bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sosialisasi Pemanfaatan Internet Sehat dan Aman Dikalangan Remaja Agar Tercipta Kemandirian Belajar
Authors: Yenni Yusli , Hutabri Ellbert 
Published: February 2022

Abstract Computer information technology in helping human life is growing very rapidly. This technological development is also supported by internet technology which can be accessed by everyone. The development of the internet can also support the learning and teaching process. Because the internet is a computer component in a computer network that can connect these components throughout the world computer network. So from that, to support the learning process it is necessary to apply the use of the internet in a healthy and safe manner. Healthy and safe use of the internet can protect internet users to avoid dangers and crimes that occur in cyberspace or are committed online. The use of the internet among adolescents is dominated by use in social media. Therefore, teenagers need to be given an understanding of using the internet safely and healthily in order to create a good learning process. This coaching is carried out on adolescents in Pesona Rhabayu housing, Patam Lestari Village, Sekupang District, Batam. This socialization provides understanding and solutions for adolescents in using the internet wisely so that they can improve learning and be error-free in using the internet so as not to damage the nation's young generation. Keywords: internet; learning; social media;Abstrak: Teknologi informasi komputer dalam membantu kehidupan manusia semakin berkembangan dengan sangat pesat. Perkembanan teknologi ini juga didukung dengan teknologi internet yang mana dapat diakses oleh semua orang. Perkembangan internet juga dapat mendukung dalam proses masa belajar dan mengajar. Karena internet merupakan komponen komputer dalam jaringan komputer yang dapat menghubungkan komponen tersebut di seluruh jaringan komputer dunia. Maka dari padahal tersebut untuk mendukung proses pembelajaran perlu diterapkan penggunaan internet secara sehat dan aman. Penggunaan internet secara sehat dan aman dapat melindungi para pengguna internet untuk terhindar dari bahaya dan kejahatan yang terjadi di dunia maya atau dilakukan secara online. Penggunaan internet dikalangan remaja didominasi oleh penggunaan dalam media sosial. Maka dari hal tersebut para remaja perlu diberikan pemahaman dalam menggunakan internet dengan aman dan sehat agar tercipta proses belajar yang baik. Pembinaan ini dilakukan pada remaja pada Perum Pesona Rhabayu Kelurahan Patam Lestari Kecamatan Sekupang Batam. Sosialisasi ini memberikan Pemahaman dan solusi bagi remaja dalam memanfaatkan internet dengan bijak sehingga dapat meningkatkan belajar dan bebas dari kesalahan dalam memanfaatkan internet agar tidak merusak generasi muda bangsa.Kata kunci : internet; media sosia; pembelajaran
Pembuatan Signage Kawasan Di Kampung Romantis Kota Malang Sebagai Desa Tematik
Authors: Susanti Wiwik Dwi , Sunarya Wendy , Masnuna Masnuna 
Published: February 2022

Abstract: Kampung Romantic is one of the urban villages in Malang City which currently transforms to be a village with special interest. One of the potentials in Kampung Romantis is the decorative-plant tour and business developed by its residents. This potential can be utilized to strengthen the character of the village that upholds good relations between neighbors and families. Reviewing the standard of a tourism village, Kampung Romantis is still far from the existing standard due to a lack of adequate facilities and infrastructure. However, its location is strategic as located in the middle of the city and near shopping centers, educational and heritage areas. Considering its strategic location and the high interest of the residents in developing their village, it is important to brand the area of this village visually. An effort was made through this service program through the signage design for a logo of Kampung Romantis which can strengthen the image of that area. The stages of the service program started from observation and communication with the residents, then planning and construction for the signage design. This program had successfully produced a signage design that was constructed to brand the area of Kampung Romantis by involving the residents.Keywords: regional signage; romantic village; thematic villageAbstrak: Kampung romantis merupakan salah satu kampung kota di Kota Malang yang saat ini berupaya untuk menjadi kampung minat khusus. Wisata belanja tanaman hias yang merupakan potensi yang sekarang dapat dikembangkan oleh warganya sendiri. Potensi tersebut dapat dimanfaatkan sebagai untuk memperkuat identitas kawasan sebagai kampung kota yang tetap mengedepankan hubungan yang baik dengan tetangga dan juga keluarga. Apabila dikaji berdasarkan standar kampung wisata, maka kampung romantis masih jauh dari standar yang ada karena sarana dan prasarananya masih minim. Lokasi kampung romantis sangat strategis karena terletak ditengah Kota Malang dan juga dekat dengan pusat perbelanjaan, area pendidikan dan juga kawa-san heritage (warisan) yang ada di Kota Malang. Melihat lokasinya yang strategis serta tingginya minat warganya untuk mengembangkan menjadi kampung wisata, maka diperlukan upaya untuk dapat membranding kawasan tersebut dan juga mempercantik secara visual kawasan tersebut. Upaya yang dilakukan dalam kegiatan pengabdian ini melalui desain signage berupa logo dari kampung romatis untuk dapat memperkuat branding kawasan tersebut. Tahapan kegiatan pengabdian dimulai dari observasi dan komunikasi dengan warga hingga perencanaan dan konstruksi signage. Kegiatan pengabdian ini berhasil membuat rancangan signage yang akhirnya dapat dibangun untuk branding di Kawasan kampung romantis dengan keterlibatan warganya.Kata kunci: desa tematik; kampung romantis; signage
Pendampingan UMKM Penjual Jamu Dalam Meningkatkan Penjualan Melalui Kemasan, Merek, dan Label
Authors: Emilda Emilda , Wulandari Try , Lazuarni Shafiera 
Published: February 2022

Abstract:. Government policies in an effort to reduce the spread of the covid-19 virus, of course, this has an impact on MSMEs, including herbs drink sellers who sell conventionally. The herbs drink sellers in the gang sei saling still offer directly to customers by walking or getting around by bicycle. This activity aims to increase sales of herbs drink during the pandemic through packaging, brands, and labels. The method utilized in this activity is community service activities through mentoring to achieve the objectives of the activity which consists of the stages of preparation, implementation, and evaluation of mentoring activities. The implementation time of mentoring was carried out for 3 days. The implementation of this activity consists of providing an understanding of the importance of packaging, merk, and labeling in increasing sales, determining the right packaging bottles, then making brands and labeling for the sale of packaged herbs drink. In this activity, participants are not only given an understanding of the importance of packaging, brands, and labeling, but also this activity is selling herbs directly and online, having packaging, brands, and labels, increasing sales and customers.Keywords: mentoring; increased sales of herbs drink; herbs drink seller Abstrak: Kebijakan pemerintah dalam upaya menekan penyebaran virus covid–19, tentunya hal ini berdampak pada pelaku UMKM termasuk penjual jamu tradisional yang masih menggunakan metode konvensional. Penjual jamu di gang sei saling masih menawarkan secara langsung kepada pelanggan dengan cara berjalan kaki atau berkeliling menggunakan sepeda. Kegiatan ini bertujuan untuk meningkatkan penjualan jamu pada masa pandemi melalui kemasan, merek, dan label. Dalam kegiatan pengabdian masyarakat ini, metode yang digunakan adalah melalui pendampingan, untuk mencapai tujuan kegiatan yang terdiri dari tahap persiapan, pelaksanaan, dan evaluasi kegiatan pendampingan. Waktu pelaksanaan pendampingan dilaksanakan selama 3 hari. Kegiatan pelaksanaan kegiatan ini terdiri dari memberikan pemahaman mengenai pentingnya kemasan, merek, dan label dalam meningkatkan penjualan, menentukan botol kemasan yang tepat, selanjutnya adalah membuat merk dan label untuk penjualan jamu kemasan. Dalam kegiatan PkM ini, peserta tidak hanya diberikan pemahaman mengenai pentingnya kemasan, merek, dan label, tetapi juga kegiatan ini penjualan jamu secara langsung dan online, memiliki kemasan, merek, dan label, peningkatan penjualan dan pelanggan.Kata kunci: pendampingan; peningkatan penjualan jamu; penjual jamu
Pengaruh Ukuran Perusahaan, Pertumbuhan penjualan,dan leverage terhadap profitabilitas melalui rasio Roa pada sektor Food & Beverage dalam BEI periode 2015-2019
Authors: Nainggolan Mia Natalia , Sirait Andre , Nasution Okky Nawa , Astuty Fuji 
Published: February 2022

The research we created with the aim of testing the influence of company size, sales growth, and leverage to the profitability ratio of Food & Beverage companies in the Indonesian stock exchange this research in carrying out their research using illustration as many 74 sampels listed on the Indonesian impact exchange. Based on the results of the analysis and efficiency of company size and sales growth partially has no effect on profitability but leverage is partially influential so the first and second hypothesis are rejected but the third hypothesis is accepted. Based on the results of the company size, sales growth and leverage is accepted

Keywords: Company size, Sales growth, Leverage, Roa Profitability
Faktor – faktor yang Berpengaruh terhadap Nilai Perusahaan Manufaktur Sektor Aneka Industri yang Terdaftar di Bursa Efek Indonesia Periode Tahun 2015-2020
Authors: Mumpuni Suci Valiani , Maryono Maryono 
Published: February 2022

The manufacturing industry in Indonesia is developing quite rapidly, this is evidenced by the increasing number of companies that have been listed on Indonesian Stock Exchange. The Indonesian Ministry of Industry noted that until 2019 there were 639 companies belonging to the various industrial sectors, both medium and large scale. The COVID-19 pandemic has caused the cessation of a number of companies in the various industrial sectors, ranging from factories that stopped their operations and employees who were forced to be laid off. This can lead to a decrease in the company’s performance. Therefore, financial managers are required to further improve financial performance, because through good financial performance a company will become a major consideration for investors. Firm value is the result of corporate performance in a certain period of time. The aim of this research is to analyse the effect of the firm size (SIZE), profitability (ROE) and dividend policy (DPR) on firm value. The data source in this research is sourced from the financial statement of the various industrial sector in manufacturing companies listed on Indonesia Stock Exchange (BEI) period 2015-2020. Population used in this reasearh is various industrial sector in manufacturing companies. This research uses a quantitative approach with purposive sampling method. Total sample as many as 111 samples. Data processing in this research using the IBM SPSS Statisctic version 22 software. Data analysis tools used in his research is descriptive analysis and multiple regression analysis. The result of this research show that the firm size has no affect on firm value. Profitability has positive affect on firm value. Dividend policy has no affect on firm value.
Multimedia Development of Student Discipline Character Training at Police Schools Pontianak State
Authors: Sugiyono Sugiyono , Aunurahman Aunurahman , Astuti Indri 
Published: February 2022

This research refers to the design of research and development (R&D), meaning the research method used to produce the product and then test the effectiveness of the product. According to Borg and Gall (2003: 569), the design used in this study was using the design of the ADDIE learning model. These researches have proposed an integrated model between ADDIE learning designs to address their weaknesses, and leverage their strengths in guiding the process of developing training multimedia content for learning, which requires incorporatingthe needs of thetraining pe at the design stage. In this development research data collection instrument using observation teknik with observation sheet tool,. The data analysis used in this study is qualitative and quantitative. Qualitative data analysisin this study willbe conducted to find out from validation experts on the design of student discipline character training at pontianak state police school (SPN). Quantitativedata analysis techniques to find out how validation results from experts or validators against multimedia character training of quantitatively analyzed student disciplines. Quantitative data analysis techniques are carried out to find out how the results of validation from experts on the quality of multimedia training that has been designed and tested with students. The result of this study is the effectiveness of learning is the level of success that can be achieved from a particular learning method in accordance with the learning objectives that have been planned. And this can also be interpreted that a learning medium can be said to be effective when meeting criteria, achieving goals, including being able to provide influence, change or can bring results, then effectiveness can be seen from how far the goal is achieved. The more goals achieved, the more effective the multimedia training is used.
Management of Technology in the Higher Education Sector in Aceh Adoption and Measurement during the Pandemic Covid-19
Authors: Salam Rudi , Rahmawati Sri , Novita Nanda , Satria Habib , Rafi’i Muhammad 
Published: February 2022

Technology Management is used to adapt to changing environmental conditions and technological advances and to create current transformations. Based on dynamic capability theory, this paper considers technology management as capability and measures it through the technology adoption capability maturity model to investigate the relationship between technology management practice and performance. Findings from empirical studies confirm that technology management in particular technology adoption is an important source of competitive advantage and contributes to the success of an online learning process in a positive way. The learning model presented by the lecturer in learning each material with all students uses online without any face-to-face activities. At the level of success, the lecturer felt that the learning he had done during the last few days was mostly only around 45% - 50% of the total material that had been explained The negative impact felt by students is the ineffectiveness of online learning methods because lecturers and students cannot discuss actively and are constrained by time constraints on several online learning applications. addition, students feel less free to ask lecturers about materials that are not understood because they are only limited by typing WhatsApp group conversations, the quota runs out, and the number of assignments given to students is the most noticeable obstacle.
Uji Toksistas Subkronik 28 Hari Ekstrak Metanolik kombinasi Daun Benalu Teh dan Benalu Mangga terhadap fungsi Hepar Pada Tikus (Rattus norvegicus) Betina
Authors: Nida' Hatif Khusnin , Sjakoer Nour Athiroh Abdoes , Mubarakati Nurul Jadid 
Published: February 2022

ABSTRACT
Flavonoids and quercetin are metabolite compounds contained in parasite plants. The role of the compounds is as an antioxidant that can protect cell damage from free radicals,for example liver. The presence of antioxidant can neutralize and protect the liver from free radicals. Liver is an organ that is vulnerable to damage caused by drugs or toxic chemicals because the liver is the center of metabolism in the body. Can be known with indicators of increasing level of SGOT, SGPT total bilirubin and histopathologic liver. The purpose of this study to determine the effect of the combination of extracts of tea parasite and mango parasite (EMBTBM) on levels of liver function in female rats (Rattus norvegicus) for 28 days. Data were analyzed using ANOVA version Jamovi 1.0.1.0.. The number of test animals is 20 female rats were divided into four groups, group 1 as a control, group 2,3,4 as a treatment. The treatment groups was given EMBTBM with different doses of 250 mg/kgBW, 500 mg/kgBW and 1000 mg/kgBW. Based on the research results show that a significant value difference between the group was p> 0,05. Therefore EMBTBM given to female rats for 28 days with a dose of 250 mg/BW, 500 mg/kgBW and 1000 mg/kgBW in the treatment group all dose were not significantly different compared with controls. So that the level of liver function in female rats was safe (not toxic) and has no effect on liver histopathology of female wistar rats.
Keyword: Subchronic, Extract and liver function
Ferroptosis due to Cystathionine γ Lyase/Hydrogen Sulfide Downregulation Under High Hydrostatic Pressure Exacerbates VSMC Dysfunction
Authors: Jin Ruxi , Yang Ruixue , Cui Changting , Zhang Haizeng , Cai Jun , Geng Bin , Chen Zhenzhen 
Published: February 2022

Hydrostatic pressure, stretch, and shear are major biomechanical forces of vessels and play critical roles in genesis and development of hypertension. Our previous work demonstrated that high hydrostatic pressure (HHP) promoted vascular smooth muscle cells (VSMCs) two novel subsets: inflammatory and endothelial function inhibitory VSMCs and then exacerbated VSMC dysfunction. However, the underlying mechanism remains unknown. Here, we first identified that aortic GPX4 (a core regulator of ferroptosis) significantly downregulated association with VSMC novel phenotype elevation in SHR rats and hypertension patients. In primary VSMCs, HHP (200 mmHg) increased iron accumulation, ROS production, and lipid peroxidation compared with normal pressure (100 mmHg). Consistently, the ferroptosis-related gene (COX-2, TFRC, ACSL4, and NOX-1) expression was also upregulated. The ferroptosis inhibitor ferrostatin-1 (Fer-1) administration blocked HHP-induced VSMC inflammatory (CXCL2 expression) and endothelial function inhibitory (AKR1C2 expression) phenotyping switch association with elevation in the GPX4 expression, reduction in the reactive oxygen species (ROS), and lipid peroxidation production. In contrast, the ferroptosis inducer RLS3 increased HHP-induced CXCL2 and AKR1C2 expressions. These data indicate HHP-triggering ferroptosis contributes to VSMC inflammatory and endothelial function inhibitory phenotyping switch. In mechanism, HHP reduced the VSMC GSH content and cystathionine gamma-lyase (CSE)/hydrogen sulfide (H2S)—an essential system for GSH generation. Supplementation of the H2S donor-NaHS increased the VSMC GSH level, alleviated iron deposit, ROS and lipid peroxidation production. NaHS administration rescues both HHP- and RLS3-induced ferroptosis. Collectively, HHP downregulated VSMC CSE/H2S triggering GSH level reduction, resulting in ferroptosis, which contributed to the genesis of VSMC inflammation and endothelial function inhibitory phenotypes.
Associations of Visceral Adipose Tissue, Circulating Protein Biomarkers, and Risk of Cardiovascular Diseases: A Mendelian Randomization Analysis
Authors: Huang Yunying , Liu Yaozhong , Ma Yingxu , Tu Tao , Liu Na , Bai Fan , Xiao Yichao , Liu Chan , Hu Zhengang , Lin Qiuzhen , Li Mohan , Ning Zuodong , Zhou Yong , Mao Xiquan , Liu Qiming 
Published: February 2022

Aim: To evaluate the genetic associations of visceral adipose tissue (VAT) mass with metabolic risk factors and cardiovascular disease (CVD) endpoints and to construct a network analysis about the underlying mechanism using Mendelian randomization (MR) analysis.Methods and Results: Using summary statistics from genome-wide association studies (GWAS), we conducted the two-sample MR to assess the effects of VAT mass on 10 metabolic risk factors and 53 CVD endpoints. Genetically predicted VAT mass was associated with metabolic risk factors, including triglyceride (odds ratio, OR, 1.263 [95% confidence interval, CI, 1.203–1.326]), high-density lipoprotein cholesterol (OR, 0.719 [95% CI, 0.678–0.763]), type 2 diabetes (OR, 2.397 [95% CI, 1.965–2.923]), fasting glucose (OR, 1.079 [95% CI, 1.046–1.113]), fasting insulin (OR, 1.194 [95% CI, 1.16–1.229]), and insulin resistance (OR, 1.204 [95% CI, 1.16–1.25]). Genetically predicted VAT mass was associated with CVD endpoints, including atrial fibrillation (OR, 1.414 [95% CI, 1.332 = 1.5]), coronary artery disease (OR, 1.573 [95% CI, 1.439 = 1.72]), myocardial infarction (OR, 1.633 [95% CI, 1.484 =1.796]), heart failure (OR, 1.711 [95% CI, 1.599–1.832]), any stroke (OR, 1.29 [1.193–1.394]), ischemic stroke (OR, 1.292 [1.189–1.404]), large artery stroke (OR, 1.483 [1.206–1.823]), cardioembolic stroke (OR, 1.261 [1.096–1.452]), and intracranial aneurysm (OR, 1.475 [1.235–1.762]). In the FinnGen study, the relevance of VAT mass to coronary heart disease, stroke, cardiac arrhythmia, vascular diseases, hypertensive heart disease, and cardiac death was found. In network analysis to identify the underlying mechanism between VAT and CVDs, VAT mass was positively associated with 23 cardiovascular-related proteins (e.g., Leptin, Hepatocyte growth factor, interleukin-16), and inversely with 6 proteins (e.g., Galanin peptides, Endothelial cell-specific molecule 1). These proteins were further associated with 32 CVD outcomes.Conclusion: Mendelian randomization analysis has shown that VAT mass was associated with a wide range of CVD outcomes including coronary heart disease, cardiac arrhythmia, vascular diseases, and stroke. A few circulating proteins may be the mediators between VAT and CVDs.
The Predictive Value of PAK7 Mutation for Immune Checkpoint Inhibitors Therapy in Non-Small Cell Cancer
Authors: Zeng Hao , Tong Fan , Bin Yawen , Peng Ling , Gao Xuan , Xia Xuefeng , Yi Xin , Dong Xiaorong 
Published: February 2022

BackgroundTo date, immunotherapy has improved the 5-year survival rate of patients with advanced non-small cell lung cancer (NSCLC) from 4% to 15%. However, only 30%-50% of the NSCLC patients respond to immune checkpoint inhibitors (ICIs) immunotherapy. Therefore, screening patients for potential benefit with precise biomarkers may be of great value.MethodsFirst, an immunotherapy NSCLC cohort was analyzed to identify the gene mutations associated with the prognosis of ICI treatment. Further analyses were conducted using NSCLC cohort in The Cancer Genome Atlas (TCGA) project to validate the correlations between the specific gene mutations and tumor immunogenicity, antitumor immunity, and alterations in the tumor-related pathways using Cell-type Identification By Estimating Relative Subsets Of RNA Transcripts (CIBERSORT) and Gene set enrichment analysis (GSEA).ResultsIn the immunotherapy NSCLC cohort (n = 266), significantly longer overall survival (OS) rates were observed in the PAK7-mutant type (PAK7-MT) group (n = 13) than the PAK7-wild type (PAK7-WT) group (n = 253) (P = 0.049, HR = 0.43, 95%CI = 0.23-0.79). In the TCGA cohort, PAK7 mutations were correlated with the higher tumor mutation burden (TMB) (14.18 vs. 7.13, P &lt;0.001), increased neoantigen load (NAL) (7.52 vs. 4.30, P &lt;0.001), lower copy number variation (CNV), and higher mutation rate in the DNA damage response (DDR)-related pathways. In addition, PAK7 mutations were also positively correlated with immune-related genes expressions and infiltrating CD8+ T cells (0.079 vs. 0.054, P = 0.005). GSEA results showed that several tumor-related pathways varied in the PAK7-MT group, suggesting the potential mechanisms that regulate the tumor immune-microenvironment.ConclusionsThis study suggested that the PAK7 mutations might be a potential biomarker to predict the efficacy of immunotherapy for NSCLC patients. Considering the heterogeneity among the patients and other confounding factors, a prospective clinical trial is proposed to further validate the impact of PAK7 mutation on the immunotherapy outcomes in NSCLC.