bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of relationship management on manufacturer resilience in emergencies
Authors: Yang Jianhua , Liu Yuying , Kholaif Moustafa Mohamed Nazief Haggag Kotb 
Published: December 2022

PurposeThe purpose of this paper is to examine the impact of two typical relationship management approaches (trust relationship with suppliers and reciprocity) on manufacturer resilience in the context of the COVID-19 crisis. Moreover, this paper aims to deepen the understanding of environmental uncertainty's moderating effect on the association between the trust relationship with suppliers (TRS) and reciprocity.Design/methodology/approachStructural equation modeling has been used to test the hypotheses on 361 Chinese manufacturing firms' managers and independent directors during the COVID-19 crisis.FindingsThe results reveal that reciprocity positively enhances three dimensions of manufacturer resilience, namely, preparedness, responsiveness and recovery capability. Reciprocity positively mediates the relationships between TRS and preparedness, responsiveness and recovery capability. Moreover, environmental uncertainty moderates the association between TRS and reciprocity.Practical implicationsThis study highlights the critical role of reciprocity, the relational governance approach, in enhancing manufacturer resilience in practice. This paper suggests that during emergencies such as the COVID-19 pandemic, managers should adopt trust and reciprocity in supplier relationship governance to strengthen the resilience of manufacturing companies and adapt effective strategies according to the environment.Originality/valueThis study is unique in developing new scales of manufacturer resilience through interviews and surveys with Chinese manufacturers and theoretical research. Based on the social capital theory and social exchange theory, this study shed light on the role of trust and reciprocity. It also bridges relational governance theory with the literature on manufacturing firm resilience literature to help manufacturers better understand the transdisciplinary links between relationship management and resilient operations in emergencies.
SME corporate governance: a literature review of informal mechanisms for governance
Authors: Handley Karen , Molloy Courtney 
Published: December 2022

Purpose
This paper takes a structured literature review (SLR) approach to identify gaps in the literature and suggest future research opportunities. It focuses on corporate governance (CG) performed outside the formal board of directors’ structure and examines research of alternative CG of small and medium-sized entities (SMEs).

Design/methodology/approach
The authors use the SLR method to search the Scopus database, extracting and synthesising findings relating specifically to SMEs’ CG. These are tabulated and described using bibliometric software.

Findings
The authors highlight an absence of tailored theoretical approaches to understanding CG in SMEs, which differs from the governance of larger entities. They also find evidence of alternative governance structures in SME CG.

Research limitations/implications
Further research should embrace management and other theoretical perspectives and expanded methodologies, nuances in understanding offered in contextualised settings and awareness of practical implications to better understand the specific setting of CG in SMEs.

Practical implications
SMEs seek to access the scarce resources and skills external to their formal CG structures. Regulators and resource providers should mobilise facilitation and training for this expansion.

Originality/value
The authors synthesise a large body of literature to extract findings specific to SMEs. A unique contribution is our focus on alternative forms of CG in SMEs. Evidence of alternative boards points to resolutions for human capital shortages in SMEs.
Art and tourism – a systematic review of the literature
Authors: Slak Valek Nataša , Mura Paolo 
Published: December 2022

PurposeThe purpose of this study is to present a review of published academic work on art and tourism. A distinction between papers researching tourism and mentioning art just as one of tourism activities and papers covering “art tourism” specifically is proposed.Design/methodology/approachThe review is grounded on a content analysis of studies containing the words “art” and “tourism” published in the Scopus database. Moreover, to analyze papers specifically consisting of the term “art tourism” a theory‐context‐characteristics‐methods structure was used – the authors call these papers art–tourism-specific papers.FindingsWhile the number of “art and tourism” papers has been increasing in the past 40 years, little is known about “art tourism” as an independent form of tourism. This study finds limited work on art tourists’ characteristics, preferences and behaviors as costumers. No art-based research and little research with visual representations was found. Artists are very rarely participants of art tourism research.Research limitations/implicationsMost research is conceptual, and little applied research can be identified. Importantly, besides synthesizing and critically assessing the current corpus of knowledge on art tourism, this review presents a final roadmap with directions for future research. One of the limitations of this review is that only studies included in the Scopus database and published in English were considered.Originality/valueTo the best of the authors’ knowledge, this study provides the first comprehensive systematic review of published academic research on art and tourism in the past 40 years. The results of this study offer directions to future art tourism researchers.
Generative production and evaluation of ornamental plant potential of an endemic flax species for ecological landscape applications
Authors: Erken Kamil 
Published: December 2022

AbstractThe flax genus consists of several natural species, which have the potential as ornamental plants for ecological landscape applications. Linum pamphylicum subsp. olympicum is an endemic, naturally occurring flax species that can only be found in Bursa, Turkey. The aim of the study is to examine the morphological and biological characteristics of L. pamphylicum subsp. olympicum in relation to its cultivation and ornamental plant potential, and to reveal the best germination practices, as well as to establish an ex situ conservation garden. According to the results, in natural conditions, L. pamphylicum subsp. olympicum taxon forms a spreading habitus that is resistant to infertile and arid soil conditions. It covers the soil surface with an average width of 40.50 cm and average height of 16.63 cm foliage. It grows an average of 50.80 annual flowering branches. It is a natural taxon that draws attention with its bright yellow and long‐lasting flowers. Germination of L. pamphylicum subsp. olympicum seeds suffers due to physical and physiological dormancy. By this study, the germination of L. pamphylicum subsp. olympicum seeds was improved up to 92.33% by using 4000 ppm gibberellic acid (GA3) treatments. Both cold–wet stratifications with soaking in 4000 or 2000 ppm GA3 provided the fastest germination speed of T50 = 14 days. With the current study germination of L. pamphylicum subsp. olympicum seeds was improved significantly, the phenological and morphological characteristics were determined and a seed resource garden was established for ornamental plant studies.
The Incomes of Visual Artists: Which Artists, What Income?
Authors: MacNeill Kate , Lye Jenny , McQuilten Grace , Badham Marnie , Powell Chloë 
Published: December 2022

AbstractWe review a body of literature that addresses the incomes of visual artists and their participation in the labour market. It is clear that the level and composition of visual artists’ incomes varies widely, as does their engagement in different forms of employment. The lack of a consistent definition of an artist and a lack of consistency in income sources included in current data collection presents challenges for researchers. The focus of our research is on the economic status of visual artists in Australia, and we identify a number of considerations that might inform policy responses to their financial position.
Who really benefits from intraperitoneal chemotherapy for advanced ovarian cancer? A treatment‐free survival analysis of the AICE trial
Authors: Xiang Libing , Shen Lina , Chen Yulian , Guo Yi , Jiang Rong , Zhang Wen , Jia Huixun , Wu Zhenyu , Zang Rongyu 
Published: December 2022

AbstractObjectiveTo investigate whether peritoneal disease extent can predict the survival benefit of intraperitoneal/intravenous (IP/IV) chemotherapy in ovarian cancer.DesignA treatment‐free survival (TFS) analysis.SettingFive‐centre trial.PopulationAn extended follow‐up of the Additional Intraperitoneal Cisplatin and Etoposide in ovarian cancer (AICE) trial (NCT01669226), with data cut‐off on 27 August 2020. Patients were categorised into subgroups with high tumour burden (HTB) and low tumour burden (LTB).MethodsOverall survival (OS) was divided into time on protocol treatment exposure (T), time free of subsequent treatment or death (TFS) and time after the first subsequent therapy (REL). TFS analyses and quality‐adjusted OS were calculated by multiplying the mean time in each health state by its assigned utility: quality‐adjusted OS = ut × T + TFS + urel × REL.Main outcome measuresThe area under each Kaplan–Meier curve was estimated using the 96‐month restricted mean time, with threshold utility analyses used to illustrate quality‐adjusted OS comparisons.ResultsIn the HTB subgroup, the restricted mean TFS was 33.9 months and 18.7 months in the IP/IV and IV groups, respectively (p = 0.005), with a significant quality‐adjusted OS gain (13.2–16.0 months). In the LTB subgroup, IP/IV therapy yielded no survival benefit in either TFS (p = 0.268) or quality‐adjusted OS (range: 1.4–6.3 months).ConclusionsBoth TFS and quality‐adjusted OS was longer across all utility weight values with IP/IV than with standard IV therapy in the HTB subgroup, whereas patients in the LTB subgroup did not benefit from the therapy. The tumour burden of ovarian cancer should be assessed before deciding on IP/IV versus IV treatment.
Primary lung sebaceous carcinoma successfully treated with radiotherapy and pembrolizumab: A case report
Authors: Jodai Yasumiko , Hamada Shohei , Yamada Mikiko , Masuda Yuiko , Anai Moriyasu , Jodai Takayuki , Tomita Yusuke , Saeki Sho , Ichiyasu Hidenori , Sakagami Takuro 
Published: December 2022

AbstractSebaceous carcinoma is a rare cutaneous malignant tumor, usually occurring on the eyelids, head, neck, and trunk. There have been few reports about sebaceous carcinoma with primary lung cancer, for which optimal therapy has not yet been established. A 70‐year‐old man presented with a mass in the left iliac bone and tumor of the lower left lung. The morphological characteristics of the iliac bone biopsy pathology and immunostaining results showed sebaceous gland differentiation. After systemic examination, we diagnosed a primary lung sebaceous carcinoma with intrapulmonary and bone metastases. PD‐L1 was positive in 1%–24% of tumor cells, and microsatellites were stable. We detected protein kinase B (AKT1) mutations using the Oncomine Dx target test. Palliative radiotherapy (RT) of a total of 45 Gy was provided in 15 fractions to the left iliac region, which resulted in a 25% reduction in the tumor size. Subsequently, four courses of first‐line pembrolizumab led to a 30% reduction in the total tumor count. RT and pembrolizumab may be treatment options for certain rare primary sebaceous carcinomas of the lungs. A synergistic effect from RT and subsequent administration of immune checkpoint inhibitors may have contributed to tumor reduction.
Reconstruction of a full‐thickness upper third defect of the helix ear using a single‐stage chondrocutaneous composite transposition flap
Authors: Burgos‐Blasco Patricia , de Perosanz‐Lobo Dario , Rios‐Buceta Luis , Bea‐Ardebol Sonia 
Published: December 2022

AbstractThe external ear is a crucial part of the ear's anatomy for both functional and aesthetic purposes. We present a defect after the extirpation of an invasive squamous cell carcinoma, where the final defect involved the superior third of the outer ear, missing both cartilage and skin. The regional chondrocutaneous composite transposition flap of the ipsilateral auricular concha is a one‐stage technique that successfully preserves the helical rim's shape and size.
Permutation entropy and its variants for measuring temporal dependence
Authors: Huang Xin , Shang Han Lin , Pitt David 
Published: December 2022

SummaryPermutation entropy (PE) is an ordinal‐based non‐parametric complexity measure for studying the temporal dependence structure in a linear or non‐linear time series. Based on the PE, we propose a new measure, namely permutation dependence (PD), to quantify the strength of the temporal dependence in a univariate time series and remedy the major drawbacks of PE. We demonstrate that the PE and PD are viable and useful alternatives to conventional temporal dependence measures, such as the autocorrelation function (ACF) and mutual information (MI). Compared to the ACF, the PE and PD are not restricted in detecting the linear or quasi‐linear serial correlation in an autoregression model. Instead, they can be viewed as non‐parametric and non‐linear alternatives since they do not require any prior knowledge or assumptions about the underlying structure. Compared to MI estimated by k‐nearest neighbour, PE and PD show added sensitivity to structures of relatively weak strength. We compare the finite‐sample performance of the PE and PD with the ACF and the MI estimated by k‐nearest neighbour in a number of simulation studies to showcase their respective strengths and weaknesses. Moreover, their performance under non‐stationarity is also investigated. Using high‐frequency EUR/USD exchange rate returns data, we apply the PE and PD to study the temporal dependence structure in intraday foreign exchange.
Population pharmacokinetics and exposure–response analyses of daratumumab plus pomalidomide/dexamethasone in relapsed or refractory multiple myeloma
Authors: Dosne Anne‐Gaelle , Li Xia , Luo Man Melody , Nnane Ivo , Dimopoulos Meletios A. , Terpos Evangelos , Sonneveld Pieter , Kampfenkel Tobias , Carson Robin , Amin Himal , Perez Ruixo Juan , Zhou Honghui , Sun Yu‐Nien , Xu Yan 
Published: December 2022

AimA population pharmacokinetic (PPK) model was developed to characterize pharmacokinetics (PK) of subcutaneous or intravenous daratumumab administration in a new indication (i.e., combination with pomalidomide and dexamethasone [D‐Pd] in patients with relapsed or refractory multiple myeloma [RRMM]). Analyses were conducted to explore exposure–response (E‐R) relationships for efficacy and select treatment‐emergent adverse events (TEAEs).MethodsThe PPK analysis included pooled data from the D‐Pd cohorts of the phase 3 APOLLO and phase 1b EQUULEUS studies. Covariates were evaluated in the PPK model. Model‐predicted exposures to daratumumab were compared between covariate subgroups of interest and used to investigate relationships between daratumumab exposure and efficacy and safety in APOLLO.ResultsThe PPK analysis included 1146 daratumumab PK samples from 239 patients (APOLLO, n = 140; EQUULEUS, n = 99). Observed concentration–time data of daratumumab were well described by a two‐compartment PPK model with first‐order absorption and parallel linear and nonlinear elimination pathways. Treatment with D‐Pd provided similar daratumumab PK characteristics versus historical daratumumab monotherapy. The E‐R dataset contained data from 290 APOLLO patients (D‐Pd, n = 140; Pd, n = 150). The PK–efficacy relationship of daratumumab supported improved progression‐free survival for patients in the D‐Pd group vs. the Pd group. Additionally, TEAEs did not increase with increasing PK exposure in the D‐Pd group.ConclusionsThe PPK and E‐R analyses support the daratumumab subcutaneous 1800 mg dosing regimen in combination with Pd for treatment of patients with RRMM. No dose adjustment is recommended in this indication for any of the investigated factors, none of which had clinically relevant effects on daratumumab PK.
Exosomal lncRNA HOTAIR promotes osteoclast differentiation by targeting TGF‐β/PTHrP/RANKL pathway
Authors: Zhang Chengcheng , Yang Jiyong , Zhu Zhiyao , Qin Jingru , Yang Lu , Zhao Xiaoxue , Su Wan , Cai Yuejiao , Yang Jia , Wang Fengying , Chen Wenlian , Gu Honggang , Deng Haibin , Wang Zhongqi 
Published: December 2022

AbstractBone tissue is a common metastatic site of lung cancer, and bone metastasis is characterized by abnormal differentiation and malfunction of osteoclast, and the roles of exosomes derived from lung cancer have attracted much attention. In our study, we found that the level of HOTAIR expression in A549 and H1299 exosomes was higher than those of normal lung fibrocytes. Overexpression of HOTAIR in A549 and H1299 exosomes promoted osteoclast differentiation. Furthermore, A549‐Exos and H1299‐Exos targeted bone tissues, and bone formation was significantly inhibited in vivo. Mechanistically, exosomal lncRNA HOTAIR promoted bone resorption by targeting TGF‐β/PTHrP/RANKL pathway.
Identification of a signature based on non‐apoptotic regulatory cell death to improve prognosis prediction in acute myeloid leukaemia
Authors: Zheng Yu , Weng Xiangqin , Hu Dong , He Jing 
Published: December 2022

SummaryAlthough anti‐apoptotic cell death is a common feature of cancer and non‐apoptotic regulatory cell death (RCD) is highly correlated with cancer progression and response to therapy, its prognostic role in patients with acute myeloid leukaemia (AML) is unknown. The RNA sequence and clinical data from AML patients were downloaded from the TCGA and GEO databases. The prognostic characteristics of non‐apoptotic RCD‐related genes (NRGs) were determined by Cox and LASSO regression analysis. Thirteen NRG signatures were identified as independent prognostic parameters in patients with AML that outperformed other prognostic models. Higher NRG scores were associated with shorter survival and less retention of tumour mutations. Although patients with high NRG risk have abundant signalling pathways for cell adhesion, cytokine upregulation, and cellular defence responses, patients with low NRG risk may benefit the most from immunotherapy. Specifically, patients with high NRG score may benefit from treatment with anti‐EGFR and CDK2 inhibitors, including erlotinib and roscovitine. The NPM1 and FLT3 mutant cell lines undergo alterations after multiple drug treatments. Our established NRG signature and scoring highlight its vital clinical significance, emphasize the inevitability of stratifying treatment for different mutation subtypes and provide new ideas to guide personalized immunotherapy strategies for AML patients.
Immune correlates of protection by vaccine against SARS‐CoV‐2 in patients with chronic lymphocytic leukaemia
Authors: Sorcini Daniele , De Falco Filomena , Gargaro Marco , Bozza Silvia , Guarente Valerio , Cardinali Valeria , Stella Arianna , Adamo Francesco Maria , Silva Barcelos Estevao Carlos , Rompietti Chiara , Dorillo Erica , Geraci Clelia , Esposito Angela , Arcaleni Roberta , Capoccia Silvia , Mameli Maria Grazia , Graziani Alessandro , Moretti Lorenzo , Cipiciani Alessandra , Riccardi Carlo , Mencacci Antonella , Fallarino Francesca , Rosati Emanuela , Sportoletti Paolo 
Published: December 2022

SummaryIn chronic lymphocytic leukaemia (CLL) the efficacy of SARS‐CoV‐2 vaccination remains unclear as most studies have focused on humoral responses. Here we comprehensively examined humoral and cellular responses to vaccine in CLL patients. Seroconversion was observed in 55.2% of CLL with lower rate and antibody titres in treated patients. T‐cell responses were detected in a significant fraction of patients. CD4+ and CD8+ frequencies were significantly increased independent of serology with higher levels of CD4+ cells in patients under a Bruton tyrosine kinase (BTK) or a B‐cell lymphoma 2 (BCL‐2) inhibitor. Vaccination skewed CD8+ cells towards a highly cytotoxic phenotype, more pronounced in seroconverted patients. A high proportion of patients showed spike‐specific CD4+ and CD8+ cells producing interferon gamma (IFNγ) and tumour necrosis factor alpha (TNFα). Patients under a BTK inhibitor showed increased production of IFNγ and TNFα by CD4+ cells. Vaccination induced a Th1 polarization reverting the Th2 CLL T‐cell profile in the majority of patients with lower IL‐4 production in untreated and BTK‐inhibitor‐treated patients. Such robust T‐cell responses may have contributed to remarkable protection against hospitalization and death in a cohort of 540 patients. Combining T‐cell metrics with seroprevalence may yield a more accurate measure of population immunity in CLL, providing consequential insights for public health.
Metabolic and physiological responses to graded exercise testing in individuals with type 1 diabetes using insulin pump therapy
Authors: McCarthy Olivia M. , Kristensen Kasper Birch , Christensen Merete Bechmann , Schmidt Signe , Ranjan Ajenthen G. , Nicholas Chloe , Bain Stephen C. , Nørgaard Kirsten , Bracken Richard 
Published: December 2022

AbstractAimsTo profile acute glycaemic dynamics during graded exercise testing (GXT) and explore the influence of glycaemic indicators on the physiological responses to GXT in adults with type 1 diabetes using insulin pump therapy.MethodsThis was a retrospective analysis of pooled data from four clinical trials with identical GXT protocols. Data were obtained from 45 adults with type 1 diabetes using insulin pumps [(30 females); haemoglobin A1c 59.5 ± 0.5 mmol/mol (7.6 ± 1.0%); age 49.7 ± 13.0 years; diabetes duration 31.2 ± 13.5 years; V̇O2peak 29.5 ± 8.0 ml/min/kg]. Integrated cardiopulmonary variables were collected continuously via spiroergometry. Plasma glucose was obtained every 3 min during GXT as well as the point of volitional exhaustion. Data were assessed via general linear modelling techniques with age and gender adjustment. Significance was accepted at p ≤ .05.ResultsDespite increasing duration and intensity, plasma glucose concentrations remained similar to rest values (8.8 ± 2.3 mmol/L) throughout exercise (p = .419) with an overall change of +0.3 ± 1.1 mmol/L. Starting glycaemia bore no influence on subsequent GXT responses. Per 1% increment in haemoglobin A1c there was an associated decrease in V̇O2peak of 3.8 ml/min/kg (p < .001) and powerpeak of 0.33 W/kg (p < .001) concomitant with attenuations in indices of peripheral oxygen extraction [(O2 pulse) −1.2 ml/beat, p = .023].ConclusionIn adults with long‐standing type 1 diabetes using insulin pump therapy, circulating glucose remains stable during a graded incremental cycle test to volitional exhaustion. Glycaemic indicators are inversely associated with aerobic rate, oxygen economy and mechanical output across the exercise intensity spectrum. An appreciation of these nexuses may help guide appropriate decision making for optimal exercise management strategies.