bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corruption During Non-Natural Disaster: Is Death Penalty Necessary?
Authors: Abdaud Faisal , Sung Ming-Hsi , Umar Wahyudi 
Published: October 2022

Extraordinary measures are needed to combat corruption in Indonesia which has been characterised as an extraordinary crime. This includes the application of death penalty as governed in Section 2 point (2) of the Corruption Eradication Act 1999. This paper intends to analyse the implementation of the aforementioned article on corruption case that occurs during the COVID-19 outbreak. This normative legal research relies on secondary date which are collected from various sources including books, journals, related legislation. The result of the research shows that, in regard to corruption case, the death penalty is only applicable when the corruption is committed in certain circumstances as intended in Section 2 point (2) of the Corruption Eradication Act 1999 and its amendment. These include the event of state emergency and national natural disaster. By virtue of the principle of legality, death penalty cannot be applied to the corruption cases that occurs during the national non-natural disaster like the Covid-19 pandemic. Reinterpretation of the phrase "certain circumstances" is needed for the sake of promoting justice. They should include national non-natural disasters like the Covid-19 pandemic.
Entrepreneurial Practices as a Panacea for Unemployment in Nigeria
Authors: Vincent I.O ODIRI, , Joy MACAULAY, 
Published: October 2022

This study investigated whether entrepreneurial practices serve as a panacea for unemployment in Nigeria using the descriptive survey design. Primary data (questionnaire) was the major instrument of data collection, which was administered on 276 respondents out of which 263 questionnaire were fully retrieved. The respondents were made up of successful listed entrepreneurship ventures in Bayelsa and Delta States, Nigeria. The dependent variable is management of unemployment while the independent variables are entrepreneurial practices (such as time management, strategic thinking, resilience and trend adjustment). Cronbach alpha (a) reliability test was used in validating the research instrument of the study, yielding a Cronbach Alpha of 0.78. Data obtained were analyzed using descriptive statistics (simple percentages and mean responses). Given the analysis, it was found that entrepreneurial practices serve as a panacea for unemployment in Nigeria. Based on the findings of this study, it was recommended among others that entrepreneurs should acquire time management skill because it is a core quality of all successful businesses and entrepreneurs should practice long-range planning and have good time attitudes in opening and closing time of their businesses. Also, entrepreneurs should not take decision quickly when confronted with unpleasant situation affecting their businesses; they should apply strategic thinking and foresights in order to make right decisions.
EFL students’ perception of Grammarly’s feedback and how they deal with the inaccuracy
Authors: Ummah Lailatul Khoiroh , Bisriyah Maslihatul 
Published: October 2022

Grammarly is one of the famous Automated Writing Evaluation (AWE) tools used by EFL students. Many studies have revealed that this tool can improve students’ writing. However, studies evaluating Grammarly’s feedback accuracy, especially the premium version, are still limited. This study aims to: (1) explore EFL students' perceptions of Grammarly premium feedback, (2) provide a detailed analysis of types of inaccurate feedback provided by Grammarly premium, and (3) investigate how students handle inaccurate feedback. This mix method study used a questionnaire, semi-structured interviews, and documentation to collect the data. The participants were undergraduate EFL students who were writing or had completed their thesis. The results indicate that: (1) students have positive and negative perceptions on the use of Grammarly Premium. They claimed that Grammarly Premium helped them in writing. The ‘correctness’ feature improved spelling, grammar, punctuation, convention, article, and consistency. The ‘clarity’ feature improves readability, such as conciseness and passive voice. The ‘engagement’ feature made writing varied and the ‘delivery’ feature to get the right tone. On the other hand, students complained about the need of a stable internet connection to work properly and require additional proofreading due to some inaccuracies. (2) Inaccurate feedback generally occurred in the features of correctness (convention, spelling, punctuation, article, and consistency), clarity (passive voice and conciseness), and engagement (variety). (3) Students continued to use Grammarly Premium because it helped them self-proofreading even though it had some shortcomings. In short, students still preferred to use Grammarly Premium with some concern in accepting the provided feedback.
Implementasi Pancasila Untuk Mencegah Isu Radikalisme Dalam Bingkai Kebhinekaan
Authors: Muhammad Robin , Widodo Slamet 
Published: October 2022

Bangsa Indonesia merupakan bangsa majemuk yang memiliki berbagai keanekaragaman budaya, bahasa, suku, ras, adat dan agama Keragaman budaya bangsa Indonesia dapat memicu konflik serta berpotensi memunculkan beragam pemahaman dan gerakan radikal, baik yang mengatasnamakan agama, suku, dan golongan. Namun, pada kenyatannya gerakan radikalisme muncul tidak hanya diakibatkan oleh perbedaan SARA, tetapi juga terdapat faktor dimensi global, politik, serta kesenjangan sosial yang terjadi di dalam masyarakat. Metode dari penulisan artikel ini dengan menngunakan metode studi pustaka kajiann literature. Tujuan dari penulisan ini adalah untuk menganalisis bagaimana implementasi terhadap nilai-nilai Pancasila dalam upaya mencegah penyebaran paham serta gerkan radikalisme di Indonsia. Pada saat ini implementasi nilai-nilai Pancasila dalam kehidupan masyarakat semakin memudar, hal trsebut diakibatkan oleh kurangnya kesadaran serta pemahaman masyarakat tentang makna dan arti dari nilai-nilai pancasila. Diperlukan tindakan atau upaya secara bersama dalam menerapkan nilai-nilai pancasila dalam kehidupan bermasyarakat , berbangsa, dan bernegara dalam mencegah penyebaran paham serta gerakan radikalisme guna menjaga keutuhan bangsa Indonesia dengan persatuan dan kesatuan.
Network pharmacology and bioinformatics approach reveals the therapeutic activity and action mechanism of curcumin in Alzheimer disease
Authors: Vijh Deepanshi , Imam Md. Ali , Haque Mohd Maksuf Ul , Das Subhajit , Islam Asimul , Malik Md Zubbair 
Published: October 2022

Abstract
Curcumin is a natural anti-inflammatory and antioxidant substance which plays a major role in reducing the amyloid plaques formation, which is the major cause of Alzheimer’s disease (AD). Consequently, a methodical approach was used to select the potential protein targets of curcumin in AD through network pharmacology. In this study, through integrative methods AD targets of curcumin through SwissTargetPrediction database, STITCH database, BindingDB, PharmMapper, Therapeutic Target Database (TTD), Online Mendelian Inheritance in Man (OMIM) database were predicted followed by gene enrichment, network construction, network topology, and docking studies. Gene ontology analysis facilitated identification of a list of possible AD targets of curcumin (74 targets genes). The correlation of the obtained targets with AD was analysed by Gene Ontology (GO) pathway enrichment analyses and Kyoto Encyclopaedia of Genes and Genomes (KEGG). Applying network pharmacological approach to identified key genes. Further, we performed molecular docking for analysing the mechanism of curcumin. To validate the temporospatial expression of key genes in human central nervous system (CNS), we searched the Human Brain Transcriptome (HBT) dataset. We identify top five key genes namely, PPARγ, MAPK1, STAT3, KDR and APP. Further validate the expression profiling of these key genes in publicly available brain data expression profile databases. This study concluded with novel insights into the therapeutic mechanisms of curcumin which in the future will ease the treatment of AD with the clinical application of curcumin.
Landscape Assessment of the cities in the State of Maharashtra: First Step towards Air Quality Management (AQM) &amp; Strategic implementation of mitigation plans.
Authors: Das Ananya , Ghosh Arpita 
Published: October 2022

Abstract
This study aims to understand the need for landscape assessment of the 18 non-attainment cities in the State of Maharashtra, understand, rank the cities according to the need and necessity for strategic implementation of air quality management. Air quality management is a National Clean Air Program (NCAP) initiative to curb the air pollution level in all the highly polluted Indian cities by 20%-30% till 2024. Ranking, selection of the cities consisted of a two-phase approach including a)desk research and b)field interventions and stakeholders,consultations.The first phase included ai) review of cities aii)identification of suitable indicators to inform prioritization during the ranking process, aiii)data collection and analysis of the indicators and aiv)the ranking of the cities.The second phase, i.e, field interventions included bi) Mapping of stakeholders and field visits, bii)the consultations with the stakeholders, biii)information and data collection,biv) ranking, selection of cities. Helping out in screening down of the most vulnerable cities due to air pollution.A granular level stakeholder consultation resulted in the selection of Navi Mumbai and Pune as the cities with implementation of feasible strategies. Strategic interventions like a) Strengthen the clean air ecosystem b)air quality monitoring &health impact assessment c)Skill development of the stakeholders for clean air better life.
WITHDRAWN: AZD5153 enhances the oncolytic adenovirus effect by affecting the STING in cervical cancer
Authors: Dou Yingyu 
Published: October 2022

Abstract
Background: Oncolytic viruses (OVs) are potential cancer treatment therapy. However, the therapeutic efficacy of OVs was limited due to coxsackie and adenovirus receptor expression levels and antivirus immune response. In this study, we explored the effect of AZD5153, a BRD4 inhibitor, on the regulation ADV5/dE1A oncolytic effect in cervical cancer models.
Methods: The effect of AZD5153 on ADV5/dE1A infection was evaluated by using GFP-reporter assays and immunofluorescence. The effect of BRD4 inhibition was further examined by flow cytometry analysis, CCK8, ELISA Kit, RNA sequencing, vitro viral replication assays and cytopathic effect assay. The expression of STING/TBK1/IRF3/NF-KB and IFN-stimulated genes were detected by qRT-PCR and western blot. The cervical cancer xenograft mice models were used to further observe the effect of combination therapy in vivo.
Results: GFP-reporter assays showed that GFP positive cells of the AZD5153 and Adv5/dE1A group increased from 21.9% to 46.3% in Hela cells. For Caski cells, the infection rate of GFP positive cells in combination group increased from 22.7% to 34.9%. Moreover, AZD5153 caused sustained tumor regression and enhanced adenovirus E1A expression compared with Adv5/dE1A only group. Low-does AZD5153 did not induce DNA damage response, cell cycle and apoptosis. AZD5153 inhibited the expression level of IFN-stimulated genes. And BRD4 bond to the promoter of STING and regulated STING/TBK1/IRF3/NF-KB expression.
Conclusion: In summary, BRD4 inhibitor enhanced ADV5/dE1A oncolytic effect via regulating STING/TBK1/IRF3/NF-KB pathway and IFN-stimulated genes in cervical cancer.
A sensitive and selective electrochemical aptasensor based on gold nanoflower/polyethyleneimine (PEI)-functionalized metal organic framework nanocomposites for label-free determination of streptomycin in milk samples
Authors: Hui Yuanyuan , Peng Haishuai , Li Linqiang , Zhao Aiqing , Yang Ding , Wang Weizhe , Wang Bini 
Published: October 2022

Abstract
Rapid, accurate, sensitive, and real-time detection of streptomycin (STR) residues in dairy products is very important. In this work, for the first time, the gold nanoflower/polyethyleneimine functionalized metal organic framework (AuNF-PEI-MIL-101(Cr)) nanocomposites were synthesized via hydrothermal method and characterized using various techniques (SEM, TEM, XRD, FT-IR and XPS). Then, a novel electrochemical aptasensor was constructed for the detection of STR based on AuNF-PEI-MIL-101(Cr) nanocomposites. The gold electrode (GE) modified with AuNF-PEI-MIL-101(Cr) can immobilize a large number of thiolated STR aptamer via the Au-S bond. When the target STR was in the presence, the current signal was reduced due to the specific binding of STR towards the aptamer. The results indicated that the aptasensor had a wide linear range towards STR (0.01–400 nM) with a low detection limit of 0.003 nM under the optimal conditions. Moreover, the aptasensor exhibited good selectivity, reproducibility, and stability. In addition, the STR in the cow, sheep, and goat milk samples was detected by the spiked recovery method, and satisfactory results were obtained. The method provides an efficient pathway for the sensitive detection of STR.
Earthworm mediated nutrient recovery and sustainable management of rice weed Barnyard grass (Echinochloa crus-galli)
Authors: Gupta Renuka , Mago Monika , Garg Vinod Kumar 
Published: October 2022

Abstract

Present research is an attempt to manage Barnyard grass(Echinochloa crus-galli), common rice weed, sustainably by vermicomposting technology.E. crus-galli(EC) feed stocks were blended with cow dung in combination: 20:80, 40:60, 50:50, 60:40 and 80:20 with two controls 100% CD and 100% EC for 63 days. Earthworms could not grow well in higher percentage of EC. Total kjeldhal nitrogen, total available phosphorus and total potassium in final vermicomposts were in range of 13.6-21.5g/kg, 11.8-15.9g/kg and 20.1-27.6g/kg, respectively, after 63 days vermicomposting. Respiration rate (42–98 mgCO2kg− 1VC 48h− 1) affirms vermicompost maturity and falls within the recommended limits (< 120 mgCO2kg− 1VC 48h− 1). Vermicomposting also reduced the weed mass by 2.2–3.03 folds depicting effective feed decomposition. It was inferred that rice weed can be converted into nutrient embedded manure employing vermicomposting and can prove to be instrumental in facilitating management ofE .crus-galliin a cost effective and environmentally modest manner.
Communication medium in theileriosis control: the factors that determine disease knowledge among smallholder farmers in Zimbabwe.
Authors: Nhokwara Shelton Munyaradzi , KONO Hiroichi , KUBOTA Satoko , Jubenkanda Mark 
Published: October 2022

Abstract
In any economy, communication in agriculture is essential for the development of the sector. It is of crucial that the government invests in meaningful, lasting communication to keep farmers informed and updated on productivity issues. The extension services in agriculture are responsible for communication between farmers and the government; inadequate communication results in limited knowledge among farmers possibly affecting total productivity. Theileriosis is one of the most important tick-borne diseases that has been affecting farmers and thousands of livestock. The main government strategy to combat theileriosis is use of plunge dips with anti-tick chemicals at specified times; however, an increase in number of farmers caused a strain on government services resulting in disease outbreak. Hence, it is important to evaluate the communication between farmers and veterinary services and identify possible areas of strain. A field survey was conducted with 320 farmers in Mhondoro Ngezi, a district badly affected by theileriosis. Face-to-face interviews with smallholders and communal farmers were conducted between September and October 2021, and the data were analyzed using Stata 17. Communal farmers relied mainly on oral communication and had limited knowledge of theileriosis; therefore, dead cattle % was high among them. Though veterinary extension officers were the prime source of information, oral communication medium affected knowledge transferred. The results of this study recommend adoption of communication mediums that encourage retention, such as brochures and posters by veterinary extension services. The government may also partner with private players to ease pressure of increased farming population due to land reform
Visual Impairment and Associated Factors among randomly selected Secondary School Students of Assosa Zone, North West Ethiopia
Authors: Maru Lemlemu , Yitayew Meseret , Getu Degu , Melkamu Solomon , Debebe Wondowessen 
Published: October 2022

Abstract
Background:Visual impairment is a major health issue that imposes a great burden to all nations globally. Ethiopia is one of the developing countries in Africa, with poor health service coverage especially eye health care and is believed to have one of the world’s highest rates of blindness.
Objective of the study: to assess prevalence of visual impairment and associated factors among high school students of Assosa zone, South West Ethiopia
Materials and methods: Institutional based cross sectional study design was used to assess prevalence of visual impairment and its associated factors among high school students of Assosa zone, South West Ethiopia using multi stage sampling. Data was fed into Epidata 4.4.2.win 64 and exported to SPSS version 20. Binary Logistic Regression (bivariate and multivariate analysis with backward LR) was used to identify the associated factors to visual impairment. Data expressed in percentage, mean, ± SD and P-value ≤0.05 considered as a statistically significant. Data presented with text, tables
Results:In the present study, response rate was 97.6%. Among 492 randomly selected high school students, 249(50.6) were females. The mean age was 17.27(SD±1.14) with minimum and maximum age of 14 and 31, respectively. Majority of participants 453(92.1%) were urban residents. In this cross-sectional study, the prevalence of visual impairment accounts for 10.4%.
Conclusion: school type, spending on cell phone, duration of reading books, not participating in sport and no history of seeking eye were factors associated with visual impairment.
Efficacy of Silver Diamine Fluoride in Arresting Dental Caries in Primary Teeth
Authors: Gyawali Namrata , Sundas Sunanda , Sah Barun Kumar , Dhakal Neha 
Published: October 2022

Abstract
Background
This study was done to evaluate and compare the efficacy of silver diamine fluoride in arresting dental caries at different frequencies of applications.
Methods
Experimental study was conducted among ten preschool children of 3–5 years old with seventy- four active carious lesions taking teeth as a sample unit. Children were randomly allocated into two intervention groups. Group 1— application of 38% silver diamine fluoride solution at three consecutive weeks and Group 2— three applications of 38% silver diamine fluoride solution at monthly interval. Time taken of caries arrest was recorded. Data was collected and entered in Microsoft Excel sheet and analysis was done in Statistical Package for the Social Sciences (SPSS) version 16.
Results
Mean time taken for caries arrest for Group II (57.20 days) was found to be statistically longer than Group I (21.54 days) (p-value < 0.001). As the mean time taken for caries arrest for Group I was shorter, the weekly application was found to have higher efficacy than the monthly application.
Conclusions
Efficacy of Silver Diamine Fluoride was found to be more in Group I (weekly application) compared to Group II (monthly application).
Simple grip strength device for assessing the degree of recovery from residual neuromuscular blockade after general anaesthesia: An observational study
Authors: Tan Xinmin , Lu Yan , Li Yiming , Li Ruhong 
Published: October 2022

Abstract
Background：Residual neuromuscular blockade is common in patients after general anesthesia, but few anesthesiologists use neuromuscular monitoring. In order to reduce the incidence of residual neuromuscular blockade and find a safer time for extubation, the purpose of our study is to explore the use of a simple measure of grip strength to roughly assess the recovery degree of neuromuscular blockade.
Methods: Seventy-six patients undergoing elective general anaesthesia from November 2021 to June 2022, aged 18-70 years, with ASA classification of grade I-II were selected. A random number table method was used to divide into rocuronium and cis-atracurium groups. Patients' gender, age, BMI, ASA classification, total duration of surgery, PACU stay, preoperative basal grip strength values were recorded using a simple grip strength device, while the corresponding grip strength values at train-of-four (TOF) ration of 70%, 80% and 90% were monitored using a neuromuscular monitor. Spearman's correlation analysis was used to analyse the correlation between grip strength values and neuromuscular monitor values to determine whether the simple grip device could be used as a crude assessment of the degree of neuromuscular blockade recovery.
Results: There was a significant correlation between grip strength values measured by the simple grip strength device and TOF ration during the patients' recovery from general anaesthesia (R2 =0.632). There was no significant difference in mean maximum grip strength recovery values between patients using rocuronium and those using cis-atracurium at the same TOF ration (p>0.05), and there was no significant difference in the total time of surgery (p=0.489) and total time spent in the PACU (p=0.202) between the two groups. There was a significant difference in preoperative basal grip strength values by gender (p<0.001), but there was no significant difference in mean maximum grip strength recovery at 70%, 80% and 90% of TOF ration and total time spent in the PACU (p>0.05).
Conclusions: In this study, we developed a significant correlation between this simple grip strength device measurement and TOF ration from quantitative neuromuscular monitoring, which can be used as an additional strategy to roughly estimate the degree of myosin recovery, further improvements in grip strength measurement are needed.