bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strontium ion attenuates osteoarthritis through inhibiting senescence and enhancing autophagy in fibroblast-like synoviocytes
Authors: Liao Binghui , Ding Ming , Wang Yingchun , Xu Hu , Shangguan Lei 
Published: August 2022

Abstract
Osteoarthritis (OA) mainly occurs in the elderly population and seriously affects their quality of life. The strontium (Sr) ion has shown positive effects on the bone tissue and promises on OA treatment. However, the adequate treatment dosage and the underlying mechanisms are unclear. This study investigated the effect of different concentrations of Sr ion on a mouse model of OA induced by destabilization of the medial meniscus (DMM) surgery, as well as the underlying mechanisms. DMM-induced OA mice were received intra-articular injection different concentration Sr ion, and found a suitable concentration of Sr ion to improve OA. Furthermore, the mechanism by which Sr ion mediated senescence and autophagy of fibroblast-like synoviocytes (FLSs) in Synovial tissues of DMM-induced OA mice were investigated. In OA mice treated with 10 µl contained 5 mmol/L SrCl2 showed the best effect on improved the pain-related behaviors and cartilage damage. In addition, in vivo and vitro experiments revealed that Sr ion inhibits senescence and improves autophagy function of FLSs. We also found that enhancement of autophagy function of FLSs can effectively slow down itself senescence. Therefore, we show that Sr ions through AMPK/mTOR/LC3B-Ⅱ signal axis improves FLSs autophagy function and delays FLSs senescence, furthermore, improve OA. These results suggest that senescence and autophagy function of FLSs may serve as promising targets for OA treatment and Sr ion may inhibit OA progression through these two targets.
Semantic Similarity Measure for Topic Modeling Using Latent Dirichlet Allocation and Collapsed Gibbs Sampling
Authors: Ajinaja Micheal Olalekan , Adetunmbi Olusola Adebayo , Ugwu Chukwuemeka Christian , Solomon Popoola Olugbemiga 
Published: August 2022

Abstract
One of the key applications of Natural Language Processing (NLP) is to automatically extract topics from large volumes of text. Latent Dirichlet Allocation (LDA) technique is commonly used to extract topics based on word frequency from the pre-processed documents. A major issue of LDA is that the quality of topics extracted are poor if the document do not coherently discuss a single topic. However, Gibbs sampling uses word by word basis which changes the topic assignment of one word and can be used on documents having different topics. Hence, this paper proposed a hybrid based semantic similarity measure for topic modelling using LDA and Gibbs sampling to exploit the strength of automatic text extraction and improve coherence score. Unstructured dataset was obtained from a public repository to validate the performance of the proposed model. The evaluation carried out shows that the proposed LDA-Gibbs had a coherence score of 0. 52650 as against LDA coherence score 0.46504. The proposed multi-level model provides better quality of topics extracted.
Effect of different synthesis routes on the morphology, optical, colorimetric, and photocatalytic properties of β-Ag2MoO4 microcrystals
Authors: Lopes Francisco Henrique Pereira , Noleto Luis Fernando Guimarães , Vieira Vitória Eduardo Mendes , de Sousa Priscila Brandão , Jucá Amanda Carolina Soares , Oliveira Yáscara Lopes , Costa Keyla Raquel Batista da Silva , Gouveia Amanda Fernandes , Almeida M. A.P. , Cavalcante Laecio Santos 
Published: August 2022

AbstractIn this paper, the effect of different synthesis methods, such as controlled precipitation (CP), sonochemical (SC), hot solution ion injection with fast cooling (HSIIFC), and conventional hydrothermal (CH) in obtaining silver beta molybdate (β-Ag2MoO4) were reported. X-ray diffraction patterns, Rietveld refinement data, cluster modeling, micro-Raman, and Fourier transform infrared spectroscopies confirmed that all β-Ag2MoO4crystals have a spinel-like cubic structure, space group (Fd\(\stackrel{-}{3}\)m), and symmetry point group (\({O}_{h}^{7}\)). Field emission scanning electron microscopy (FE-SEM) images showed that through different synthetic routes, it is possible to obtain monophasic crystals, such as regular/irregular polyhedral, potatoes, and non-uniform. Ultraviolet-Visible (UV-Vis) spectroscopy measurements in absorbance mode showed three main absorptions (280, 310, and 340 nm). In contrast, the UV-Vis analysis in diffuse reflectance mode showed a tail of energy absorption in the UV spectrum range (3.25 eV and 3.3 eV). The quantitative data from the colorimetric analysis indicated that the β-Ag2MoO4crystals are desirable for developing inorganic pigments with a beige to brown shade. Photocatalytic tests were performed using four lamps: UV-C, UV-B, UV-A, and visible light. The β-Ag2MoO4crystals prepared by the PC method showed a higher degradation rate ≈ 85.12% for the rhodamine B dye solution under 240 min of exposure to UV-C light.
A Methodology to Estimate Human-Robot Interaction Forces: A Case Study of a 4-DOFs Upper Extremity Rehabilitation Robot
Authors: Cao Qiang , Li Xuanhan , Li Jianfeng , Dong Mingjie , Zhang Zekun 
Published: August 2022

Abstract
Due to the advantages of high durability, great repeatability and task orientation, the upper extremity rehabilitation robots have become a gospel for the rehabilitation treatment of stroke patients. The evaluation system for the comfort performance of rehabilitation robots has always been a research hotspot, and how to calculate the human-robot interaction forces is a challenge for the comfort evaluation. In this article, a four degrees of freedom (4-DOFs) upper extremity robot mechanism that is kinematically compatible with the upper limb is presented. Then, taking this mechanism as the research object, an algorithm for estimating human-robot interaction forces is addressed based on Newton-Euler dynamic. Subsequently, a prototype of the proposed robot is developed, and a comparison experiment of interaction forces is carried out on the prototype. The comparative experimental outcomes indicate that the presented algorithm for calculating the human-robot interaction forces is feasible. The findings of this paper provide a prerequisite for the evaluation of the robot comfort, which is of great practical significance.
Genetic diversity and Population structure assessment of 22 wild Macrobrachium nipponense populations across China: Implications for genetic resources protection and population management
Authors: Jiang Sufei , Xiong Yiwei , Zhang Lijuan , Zhang Wenyi , Zheng Yalu , Wang Jisheng , Jin Shubo , Gong Yongsheng , Wu Yan , Qiao Hui , Fu Hongtuo 
Published: August 2022

Abstract
Macrobrachium nipponense, is an important economic indigenous prawn in China, which is widely distributed in freshwater in China, Japan and Southeast Asia. In this study, D-loop region sequences was used to investigate the genetic diversity and population structure of 22 wild populations of M. nipponense through China, containing the major rivers and lakes of China. Totally 475 valid D-loop sequences from 22 populations with a length of 1110bp were obtained, and 348 variation sites and 221 haplotypes were detected. A total of 221 haplotypes were defined in 22 populations. Hap48 was the dominant haplotype, accounting for about 13%. The haplotype diversity (h) was ranged from 0.1630 (BN) ~1.0000 (AR) and the nucleotide diversity π value ranged from 0.001164 (MR) ~ 0.037168 (NR). The pairwise genetic differentiation index (FST) ranged from 0.00344 to 0.91243 and most pair-wised FST was significant (P < 0.05). The lowest FST was displayed in MR and JLR population and the highest was between NDR and NR. The phylogenetic tree of genetic distance based on UPGMA showed that all populations were divided into two branches. The DC, NDR, JLR and MR populations were clustered into one branch. The neutral test and mismatch distribution results showed that M. nipponense populations were not experienced expanding and kept a steady increase. Taken together, a joint resources protection and management strategy for M. nipponense have been suggested based on the results of this study for its sustainable use.
Fetish towards white skin - An empirical study on Indian Perspective using matrimonial advertisements
Authors: Garg Sonam , Chamoli tanishq , Gupta Ankit 
Published: August 2022

Abstract
The concept of marriages is considered to be sacred in Indian Culture, and it can be viewed as a sacred bond and unionbetween two people. Arrange marriages have become a tradition for Indian people. It has been an emblem of this Indian culturesince remote ages. In India, on a daily basis, overall of 425 million people read newspapers because newspaper advertisementsare rich sources of cultural, social, and historical information. Fair skin has been always a part of national spirit of Indians.Though, castes and classes of a person often intersect, fair skin has also been recognized for being an evidence of “betterfinancial and social status of a person.” Long time before, when globalisation arrived, Men and women considered dark skin asa disgrace to them. However, augmented promotion of light-skinned beauty in advertisements since the ongoing of economicliberalization directly points out how market forces play an important role in intensified divisions of gender, caste, religion, andclass. But, people still prefer for time-tested practicing of taking matrimonial advertisements in e-newspapers. Our objectiveof this research work is to use these ads to infer that In today’s scenario, Indian people/societies are fetish towards whiteskin. We have performed query based analysis on matrimonial advertisements in the period of 2010-21 through data miningof e-newspapers. Graphs are plotted depicting the frequency of keywords chosen for a particular time period. We also createda searchable database for all the ads for 30 newspapers of various languages. This study concluded that despite various kindsof developments on many fronts, no matter if it is technological, cultural , and social, Indians still prefer white skin whilemaking crucial decisions of their lives.
A Data-to-Image Mechanism Based on Feature Correlation for Wireless Intrusion Detection
Authors: Yu ZhiJie 
Published: August 2022

Abstract
With the rapid development of technology networks, the security problem of wireless networks is becoming more serious. Among the existing related research works on wireless network intrusion detection, Artificial Neural Network (ANN) and Deep Neural Network (DNN) are the most widely used models which can better handle multidimensional data without considering the influence of feature correlation on the results. Therefore, this study proposes an approach that calculates the feature correlation to convert non-image data into images and combines feature selection and feature extraction to improve the accuracy of CNN model detection. This approach calculates the Pearson, Spearman, and Kendall correlation coefficients to sort the features into 1D or 2D images according to the highest to the lowest correlational order. The experiment adopts the Aegean Wi-Fi Intrusion Dataset (AWID). The result shows that the best accuracy of the CNN is 99.574%, and the average accuracy is much higher than that of the DNN for non-image data.
Construction of hydrophilic covalent organic frameworks and their fast and efficient adsorption towards cationic dyes from aqueous solution
Authors: Wang Zheng , Li Anran , Zhao Bing , Kann Wei , Li Zhigang , Wang Liyang , Sun Li , Wang Xiuwen , Yin Guangming 
Published: August 2022

Abstract
Research about the functionalized covalent organic framework (COF) materials with well hydrophilic characteristics is significant on account of their application in the removal of dyes in wastewater. In this work, two anionic COF materials (TFPB-Pa-SO3H COF and TFPB-BDSA COF) were successfully synthesized with sulfonated modification as dyestuffs sorbent to be used in the adsorption of cationic dyes. Two prepared COF materials exhibited predominant hydrophilicity with lower water contact angles (35° and 27°) compared with reported COF materials. The sulfonated groups on COFs can efficiently adsorb cationic dyes through electrostatic interaction, which can moderately ameliorate the adsorptive capacity towards hydro soluble dyes. TFPB-Pa-SO3H COF and TFPB-BDSA COF showed superfast adsorption equilibrium to MLB (1 and 2 min) and the higher adsorption uptakes of CV (1559 and 1288 mg g−1), which manifested that the adsorption rate may be closely related to the solubilities of host COFs materials as well as guest dye molecule in aqueous solution; while the adsorption stability between COFs materials and the dye molecule adsorbed on the COFs skeleton accounted for the highly effective adsorption of the aim dye in large quantity. In addition, two COFs as adsorbing materials were successfully applied to the removal of dyes molecules in real water samples.
Hepatoprotective effect of morin against methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways
Authors: Kızıl Hamit Emre , Caglayan Cuneyt , Darendelioğlu Ekrem , Ayna Adnan , Gür Cihan , Kandemir Fatih Mehmet , Küçükler sefa 
Published: August 2022

Abstract
Background Organ toxicity limits the therapeutic efficacy of methotrexate (MTX), an anti-metabolite therapeutic that is frequently used as an anti-cancer and immunosuppressive medicine. Hepatocellular toxicity is among the most severe side effects of long-term MTX use. The present study unveils new confirmations as regards the remedial effects of morin on MTX-induced hepatocellular injury through regulation of oxidative stress, apoptosis and MAPK signaling. Methods Rats were subjected to oral treatment of morin (50 and 100 mg/kg body weight) for 10 days. Hepatotoxicity was induced by single intraperitoneal injection of MTX (20 mg/kg body weight) on the 5th day. Results MTX related hepatic injury was associated with increased MDA while decreased GSH levels, the activities of endogen antioxidants (glutathione peroxidase, superoxide dismutase and catalase) and mRNA levels of HO-1 and Nrf2 in the hepatic tissue. MTX treatment also resulted in apoptosis in the liver tissue via increasing mRNA transcript levels of Bax, caspase-3, Apaf-1 and downregulation of Bcl-2. Conversely, treatment with morin at different doses (50 and 100 mg/kg) considerably mitigated MTX-induced oxidative stress and apoptosis in the liver tissue. Morin also mitigated MTX-induced increases of ALT, ALP and AST levels, downregulated mRNA expressions of matrix metalloproteinases (MMP-2 and MMP-9), MAPK14 and MAPK15, JNK, Akt2 and FOXO1 genes. Conclusions According to the findings of this study, morin may be a potential way to shield the liver tissue from the oxidative damage and apoptosis.
Spatiotemporal trip pattern analysis in a regional bus network with limited automated fare collection data: a case study of the Pioneer Valley
Authors: Mohammed Mohammed , Oke Jimi 
Published: August 2022

Abstract
Understanding passenger trip patterns is crucial to enabling transit agencies plan effectively and equitably, particularly in response to disruptive events. However, current data collection systems either do not collect detailed passenger behaviour or are expensive to implement. In this paper, we exploit the relatively cheap big data collected by a mobile ticketing system to efficiently extract distinctive travel patterns. We employed our methods on a sample of anonymized data from the Pioneer Valley Transit Authority in Massachusetts. First, we applied a greedy approach to infer trip boarding stop locations. Then we computed the multi-dimensional dissimilarity of the passenger activation time series using the AWarp alignment algorithm, which works well with sparse data. Finally, we clustered these spatiotemporal patterns using hierarchical clustering. Our novel method has resulted in four spatiotemporal trip pattern typologies which we analysed based on demographics, hourly and daily distributions, faretypes, trip length and duration, among other metrics. Three of the typologies were associated with regular commuters, differentiated by either boarding time or transfer propensity. The fourth typology was mostly associated with leisure or other activities. Beyond yielding insights and facilitating demand estimation for planners in the study area, we expect that our framework can be readily applied to aid future decision-making efforts in similar study areas with minimal data availability.
Rice glycosyltransferase gene UGT2 functions in salt stress tolerance under the regulation of bZIP23 transcription factor
Authors: Wang Ting , Li Xing-kun , Liu Xi , Yang Xian-qin , Li Yan-jie , Hou Bing-Kai 
Published: August 2022

Abstract
UDP-glycosyltransferases (UGTs) play key roles in modulating plant responses to environmental challenges. In this study, we characterized a novel glycosyltransferase, UGT2, which plays an important role in salt stress responses in rice (Oryza sativa L). We found that seedlings overexpressing UGT2 exhibited better growth than wild type in shoot and root under hydroponic culture with salt stress treatments, while ugt2ko mutant lines suffered much more growth inhibition. When the soil-grown UGT2 transgenic plants were subjected to salt stress, we also found that ugt2ko mutant lines were severely withered and most of them died, while the overexpression lines grew well and had higher survival rate. Compared with wild type plants, UGT2 overexpression greatly increased the expression levels of the reactive oxygen species scavenging genes and stress responsive genes. Furthermore, the upstream regulatory mechanism of the UGT2 gene was identified and we found that a bZIP transcription factor, OsbZIP23, can bind to the UGT2 promoter and enhance the UGT2 transcription levels. This work reveals that OsbZIP23-UGT2 module may play a major role in regulating the salt stress tolerance in rice.
Characterization of lateritic soil based on literature and lab testing
Authors: Roshan Mohammad Jawed , Hezmi Muhammad Azril , Rashid Ahmad Safuan A , Ullah Rafi , Ullah Arshad 
Published: August 2022

Abstract
Lateritic soil resulting from weathering, particularly the chemical weathering process of rocks, is found widely in tropical and subtropical countries such as Malaysia, Thailand, Singapore, and Brazil. The characteristics of this residual soil depend on many factors, including weathering degree, chemical compositions, and laterization degree, indicating their varying properties from one place to another. Thus, it is essential to explore their characteristics before using them as a construction material for a particular structure. In this paper, a lateritic soil sampled from Universiti Teknologi Malaysia has been explored in terms of grain size distribution (GSD), Atterberg limits, specific gravity, compaction, unconfined compressive strength (UCS), unconsolidated undrained (UU) test, FESEM, and EDX. The obtained results indicated that the soil is classified as plastic silt (MH) and A-7-5 according to USCS and AASHTO methods, respectively. The optimum moisture content (OMC) and maximum dry density (MDD) were obtained 28 % and 1.39 g/cm3, respectively, based on the standard compaction method. The unconfined compressive strength (UCS) is 200.75 kPa, whereas, in the unconsolidated undrained (UU) test, the deviator stress is equal to 449.4 kPa, 529.3 kPa, and 674 kPa for 50, 100, and 200 kPa, respectively. The total friction angle and undrained cohesion are 25.69° and 115.82 kPa, respectively. According to the FESEM results, the matrix microstructure was detected for the soil. The O, Al, Si, and Fe were detected as primary chemical elements in the soil. The results of this study can help the practitioners to classify the laterite soil and decide based on its characteristics.
Steady-state study and implementation of an AC-AC converter for WECS
Authors: Gutiérrez-Torres Diego , Ramirez Juan M , Lozano-García José M. 
Published: August 2022

Abstract
This paper aims to present the design and implementation of a three-phase and modular direct matrix converter, controlled by the Singular Value Decomposition (SVD) modulation strategy, which offers several operational advantages. A prototype that emulates a Wind Energy Conversion System (WECS) that incorporates the matrix converter as the main element that links the electrical generator and the electrical grid is presented. The simulation and experimental results corroborate that the matrix converter is a convenient option to take into account for this type of application.
Comparing the efficacy and safety profiles of 0.025% and 0.05% tretinoin creams in treating acanthosis nigricans: A randomized double-blinded study
Authors: Kritsanaviparkporn Chawan , Treesirichod Arucha 
Published: August 2022

AbstractBackground:Acanthosis nigricans (AN) is a skin disorder with hyperpigmented and velvety plaques without a standardized treatment regimen. We aimed to compare the efficacy and safety profile of 0.025% and 0.05% tretinoin creams in managing AN.Material and Methods:An 8-week, randomized double-blinded study was conducted in adults with AN. Participants were instructed to apply tretinoin cream on their posterior neck. Narrowband reflectance spectrophotometry was used to measure skin improvement through melanin (M) and erythema (E) indices at each follow-up visits at weeks 2, 4, and 8. Improvements in Acanthosis nigricans scoring chart (ANSC), investigator- and patient-global evaluation (IGE and PGE) and adverse cutaneous irritations were also scored.Results: Both the 0.025% and 0.05% tretinoin creams were efficacious in acanthosis nigricans treatment with 17.1±8.0% improvement and 18.4±9.8% improvement after 8 weeks treatment by reflectance spectrophotometry measurement, respectively. There were generally no significant differences in efficacy, improvements in ANSC, IGE, and PGE scores, and local cutaneous irritations between the two groups.Conclusion: The 0.025% and 0.05% tretinoin demonstrate similar efficacy and safety profiles in the management of AN. Both concentrations are well-tolerated with mild degree of local cutaneous irritation.
A unique type of short-segment Hirschsprung Disease, predicting a worse prognosis?
Authors: Xie Chuangping , Yan Jiayu , Guo Jianlin , Liu Yakun , Chen Yajun 
Published: August 2022

Abstract
Purpose: To identify that a unique type of short-segment Hirschsprung Disease (SHD), presenting as a suddenly dilated bowel without a visible transition zone on a preoperative barium enema, have a delayed diagnosis and worse prognosis.Methods: A comparative study was performed to analyze the clinical features and prognosis between those with a visible transition zone (type Ⅱ=69) and those without (type Ⅰ=15) on preoperative barium enema.Results: Age at diagnosis and radical surgery in the type Ⅰ SHD group were significantly older than in the type Ⅱ SHD group (p=0.002 and p=0.001, respectively). Besides, patients with type Ⅰ SHD were more likely to suffer anastomosis leakage and postoperative enterocolitis after TEPT (p=0.017 and p=0.023, respectively). In addition, patients with type Ⅰ SHD are inclined to suffer lower bowel function scores (p=0.018). Further, we found that patients with type Ⅰ SHD were more likely to suffer poorer ability to hold back defecation (p=0.023), soiling (p=0.011), fecal accidents (p=0.004), and social problems (p=0.004).Conclusion: Compared with type Ⅱ SHD, type Ⅰ SHD is diagnosed and performed TEPT at an older age. Besides, patients with type Ⅰ SHD are inclined to suffer postoperative enterocolitis, anastomosis leakage, and poorer long-term bowel function following TEPT.Type of Study: A retrospective single-center studyLevel of evidence: Ⅲ