bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collider events on a quantum computer
Authors: Gustafson Gösta , Prestel Stefan , Spannowsky Michael , Williams Simon 
Published: November 2022

Abstract
High-quality simulated data is crucial for particle physics discoveries. Therefore, parton shower algorithms are a major building block of the data synthesis in event generator programs. However, the core algorithms used to generate parton showers have barely changed since the 1980s. With quantum computers’ rapid and continuous development, dedicated algorithms are required to exploit the potential that quantum computers provide to address problems in high-energy physics. This paper presents a novel approach to synthesising parton showers using the Discrete QCD method. The algorithm benefits from an elegant quantum walk implementation which can be embedded into the classical toolchain. We use the ibm_algiers device to sample parton shower configurations and generate data that we compare against measurements taken at the ALEPH, DELPHI and OPAL experiments. This is the first time a Noisy Intermediate-Scale Quantum (NISQ) device has been used to simulate realistic high-energy particle collision events.
Anmerkungen zum Terminus „Drainage“
Authors: Böttcher Arne , Meier-Vieracker Simon 
Published: November 2022

Zusammenfassung
Hintergrund
Der Gebrauch des Terminus „Drainage“ ist im klinischen Alltag und in der existierenden Fachliteratur inkonsistent.

Ziel der Arbeit
Ziel waren die Klärung der Bedeutung des Terminus und die Sensibilisierung zum fachgerechten Gebrauch.

Material und Methoden
Dazu erfolgte eine selektive Literaturrecherche.

Ergebnisse
Eine Drainage, entlehnt aus dem Englischen, ist der Vorgang des Flüssigkeitsentziehens, wird jedoch häufig mit dem oftmals zeitgleich eingelegten Drainrohr synonym verwendet, was sprachwissenschaftlich als Metonymie bezeichnet wird. Ein Paukenröhrchen dient der Mittelohrbelüftung und dem Druckausgleich. Lymph- und Abszessdrainagen sind keine Gegenstände.

Schlussfolgerung
Die normierte Fachterminologie dient dazu, Unschärfen und konsekutiv Missverständnisse im wissenschaftlichen Kontext zu verhindern. Dies ist besonders in der Medizin von großer Bedeutung, jedoch im alltäglichen Sprachgebrauch einer gewissen Variabilität unterzogen.
First bioelectronic immunoplatform for quantitative secretomic analysis of total and metastasis-driven glycosylated haptoglobin
Authors: Muñoz-San Martín Cristina , Montero-Calle Ana , Garranzo-Asensio María , Gamella Maria , Pérez-Ginés Víctor , Pedrero María , Pingarrón José M. , Barderas Rodrigo , de-los-Santos-Álvarez Noemí , Lobo-Castañón María Jesús , Campuzano Susana 
Published: November 2022

Abstract
The glycosylation status of proteins is increasingly used as biomarker to improve the reliability in the diagnosis and prognosis of diseases as relevant as cancer. This feeds the need for tools that allow its simple and reliable analysis and are compatible with applicability in the clinic. With this objective in mind, this work reports the first bioelectronic immunoplatforms described to date for the determination of glycosylated haptoglobin (Hp) and the simultaneous determination of total and glycosylated Hp. The bioelectronic immunoplatform is based on the implementation of non-competitive bioassays using two different antibodies or an antibody and a lectin on the surface of commercial magnetic microcarriers. The resulting bioconjugates are labeled with the horseradish peroxidase (HRP) enzyme, and after their magnetic capture on disposable electroplatforms, the amperometric transduction using the H2O2/hydroquinone (HQ) system allows the single or multiple detection. The developed immunoplatform achieves limits of detection (LODs) of 0.07 and 0.46 ng mL−1 for total and glycosylated Hp in buffer solution, respectively. The immunoplatform allows accurate determination using simple and relatively short protocols (approx. 75 min) of total and glycosylated Hp in the secretomes of in vitro–cultured colorectal cancer (CRC) cells with different metastatic potentials, which is not feasible, due to lack of sensitivity, by means of some commercial ELISA kits and Western blot methodology.
Graphical abstract
Automated detection of neutralizing SARS-CoV-2 antibodies in minutes using a competitive chemiluminescence immunoassay
Authors: Klüpfel Julia , Paßreiter Sandra , Rumpf Melina , Christa Catharina , Holthoff Hans-Peter , Ungerer Martin , Lohse Martin , Knolle Percy , Protzer Ulrike , Elsner Martin , Seidel Michael 
Published: November 2022

AbstractThe SARS-CoV-2 pandemic has shown the importance of rapid and comprehensive diagnostic tools. While there are numerous rapid antigen tests available, rapid serological assays for the detection of neutralizing antibodies are and will be needed to determine not only the amount of antibodies formed after infection or vaccination but also their neutralizing potential, preventing the cell entry of SARS-CoV-2. Current active-virus neutralization assays require biosafety level 3 facilities, while virus-free surrogate assays are more versatile in applications, but still take typically several hours until results are available. To overcome these disadvantages, we developed a competitive chemiluminescence immunoassay that enables the detection of neutralizing SARS-CoV-2 antibodies within 7 min. The neutralizing antibodies bind to the viral receptor binding domain (RBD) and inhibit the binding to the human angiotensin-converting enzyme 2 (ACE2) receptor. This competitive binding inhibition test was characterized with a set of 80 samples, which could all be classified correctly. The assay results favorably compare to those obtained with a more time-intensive ELISA-based neutralization test and a commercial surrogate neutralization assay. Our test could further be used to detect individuals with a high total IgG antibody titer, but only a low neutralizing titer, as well as for monitoring neutralizing antibodies after vaccinations. This effective performance in SARS-CoV-2 seromonitoring delineates the potential for the test to be adapted to other diseases in the future.
Graphical Abstract
Chitosan–caffeine formulation as an ecological preservative in wood protection
Authors: Woźniak Magdalena , Gromadzka Karolina , Kwaśniewska-Sip Patrycja , Cofta Grzegorz , Ratajczak Izabela 
Published: November 2022

AbstractNowadays, taking into account environmental degradation, climate changes, as well as, environmentally friendly regulations and increasing ecological awareness of consumers, methods of wood protection without negative impact on the environment are being intensively developed. In this study, a mixture of chitosan and caffeine was proposed as ecological wood preservative. The aim of the research was to evaluate the application of chitosan (medium and high molecular weight) as an agent limiting the leaching of caffeine from the structure of treated wood. The resistance of pine wood treated with chitosan–caffeine preparations and ingredients of these preparations (caffeine and chitosan) to brown rot fungus—Coniophora puteana was assessed. The degree of caffeine leaching from the treated wood was determined by chromatographic analysis (caffeine concentration) and elemental analysis (nitrogen concentration). The results showed that chitosan limited caffeine leaching from wood, which was confirmed by chromatographic analysis and changes in the wood structure observed in FTIR spectra. Moreover, wood treated with chitosan–caffeine preparations showed resistance against C. puteana (mass loss about 0.5%); however, antifungal activity was reduced when treated wood was subjected to leaching with water (mass loss about 10%). The obtained results suggest that the chitosan–caffeine preparations can be promising ecological preservatives for the wood treatment.
Whole exome sequencing of FFPE samples—expanding the horizon of forensic molecular autopsies
Authors: Adolfsson Emma , Kling Daniel , Gunnarsson Cecilia , Jonasson Jon , Gréen Henrik , Gréen Anna 
Published: November 2022

Abstract
Forensic molecular autopsies have emerged as a tool for medical examiners to establish the cause of death. It is particularly useful in sudden unexplained deaths where the cause of death cannot be determined with a regular medical autopsy. We provide the first study of exome data from formalin-fixed paraffin-embedded samples (FFPE) paired with data from high-quality blood samples in forensic applications. The approach allows exploration of the potential to use FFPE samples for molecular autopsies and identify variants in extensive exome data. We leverage the high uniformity of the hybridization capture approach provided by Twist Bioscience to target the complete exome and sequence the libraries on a NextSeq 550. Our findings suggest that exome sequencing is feasible for 24 out of a total of 35 included FFPE samples. When successful, the coverage across the exome is comparatively high (> 90% covered to 20X) and uniform (fold80 below 1.5). Detailed variant comparisons for matched FFPE and blood samples show high concordance with few false variants (positive predictive value of 0.98 and a sensitivity of 0.97) with no distinct FFPE artefacts. Ultimately, we apply carefully constructed forensic gene panels in a stepwise manner to find genetic variants associated with the clinical phenotype and with relevance to the sudden unexplained death.
On the aggregation of input data for energy system models
Authors: Cardona-Vasquez David , DiTondo Davide , Wogrin Sonja 
Published: November 2022

AbstractThe increasing share of variable renewable energy sources in power systems poses new challenges to policy makers and network planners alike because of the sources’ variability and insufficient energy storage capability. This requires the development of new optimization models that consider the inter-temporal connection between different periods aggregating them on a more general level (e.g., days or weeks). However, aggregation models are often empirical and based on common clustering algorithms. In this paper, we carry out a numerical exploration of the relationship between the structure of the system and the hyperparameters required for these aggregation procedures. Our findings indicate that there is valuable information from the power system that can be used to improve the aggregation. This is important because, in most cases, the accuracy of the aggregation cannot be measured exactly.
Wieviele reelle Zahlen gibt es?
Authors: Asperó David , Schindler Ralf 
Published: November 2022

ZusammenfassungDie Arbeit [2] der gegenwärtigen Autoren amalgamierte zwei prominente Axiome der gegenwärtigen Mengenlehre, von denen vorher bekannt gewesen war, daß sie beide entscheiden, daß das Kontinuum die Größe $\aleph_2$ hat, nämlich Martins Maximum und Woodins $P_max$-Prinzip (*). Wir diskutieren dieses Resultat und seine Bedeutung für das Kontinuumsproblem.
Mutter und Psychotherapie
Authors: Grubner Angelika 
Published: November 2022

ZusammenfassungDas Erstarken der Psychotherapie und der weitgehende Verlust der Mutter aus der feministischen Theorie und deren Gleichzeitigkeit mit dem Übergang vom Wohlfahrtsstaat zum neoliberalen Staat legen den Verdacht nahe, dass sie etwas miteinander zu tun haben. Insofern versucht dieser philosophische Beitrag erste Überlegungen anzustellen, wie dieser Zusammenhang aus einer feministischen Perspektive verstanden werden könnte.
The effect of cognitive workload on decision authority assignment in human–robot collaboration
Authors: Karakikes Michail , Nathanael Dimitris 
Published: November 2022

AbstractHuman–robot collaboration in dynamic industrial environments warrants robot flexibility and shifting between tasks. Adaptive robot behavior unavoidably carries decision-making needs regarding task allocation and scheduling. Such decisions can be made either by the human team members or autonomously, by the robot’s controlling algorithm. Human authority may help preserve situational awareness but increases mental demands due to increased responsibilities. Conversely, granting authority to the robot can offload the operator, at the cost of reduced intervention readiness. This paper aims to investigate the question of decision authority assignment in a human–robot team, in terms of performance, perceived workload and subjective preference. We hypothesized that the answer is influenced by the cognitive workload imposed on the human operator by the work process. An experiment with 21 participants was conducted, in which decision authority and induced workload through a secondary task were varied between trials. Results confirmed that operators can support the robot better when decision authority is allocated according to their workload. However, operator decision authority (a) may cause inferior performance at any secondary tasks performed in parallel with robot supervision and (b) increases perceived workload. Subjective preference was found to be evenly divided between the two levels of decision authority, and unaffected by task difficulty. In brief, if human–robot team performance is a priority, humans should be granted decision authority when their overall workload allows it. In high-workload conditions, system decision-making algorithms should be developed. Nonetheless, process designers should be mindful of the interpersonal differences between operators who are destined to collaborate with robots.
Stone handling in geladas (Theropithecus gelada): implications for spontaneous drawing-like activity as a playful behavior
Authors: Pallante Virginia , Johann Achim , Huffman Michael A. , Palagi Elisabetta 
Published: November 2022

AbstractStone handling (SH) is a form of solitary object play widely documented in four species of macaques and most recently also in geladas (Theropithecus gelada). Here, we describe the SH activity of two mother-reared captive gelada males, who combined different behavioral patterns in a sequence that occasionally led to the production of colored marks on a hard surface. Two playful techniques of different complexity emerged spontaneously in the two subjects. In the etching and releasing technique, the stone or pieces of it were repeatedly scraped across either a vertical or horizontal hard surface. In the grindandfinger technique, additional patterns were recruited such as scratching the stone to produce small debris that the subjects manipulated through a thumb–index finger precision grip. Animals selected preferentially hard surfaces when their SH sessions involved patterns that potentially released color and engaged in such patterns for longer and in a repeated way. This evidence suggests the high motivation of the two males to engage in drawing-like behavior that, as it occurs for other forms of play, can be characterized by its autotelic self-rewarding nature. Digital video images related to the article are available at http://www.momo-p.com/showdetail-e.php?movieid=momo220922tg01a and http://www.momo-p.com/showdetail-e.php?movieid=momo220923tg01a
The mitigating effect of Spirulina (Arthrospira platensis) on the hemotoxicity of gibberellic acid on juvenile tilapia (Oreochromis niloticus)
Authors: Sayed Alaa El-Din H. , Hamed Mohamed , El-Sayed Abdelaziz A. A. , Nunes Bruno , Soliman Hamdy A. M. 
Published: November 2022

Abstract
The use of plant growth regulators has led to environmental contamination of water bodies that occur adjacent to agricultural areas. Some of these chemicals are bioactive, not only to plants, but also to non-target exposed biota, namely of the aquatic compartment. Previous work demonstrated the establishment of hepato- and nephrotoxic effects in juvenile tilapia (Oreochromis niloticus) exposed via aquatic media to gibberellic acid (GA3), which is among the most used plant growth regulators, in agricultural practices. Here, we investigated the effect of GA3 on hematological indices, poikilocytosis, nuclear abnormalities, and genotoxic indices measured in Nile tilapia (Oreochromis niloticus), as well as the putative protective effects of dietary supplementation of Spirulina (Arthrospira platensis). Fish were evenly assorted into 5 groups: group I served as a control, and groups II–V were fed diets supplemented with Spirulina at rates of 0 g/kg, 5 g/kg, 20 g/kg, and 100 g/kg, respectively, for 2 months before being exposed to 150 mg/L GA3. The results revealed that GA3 exposure decreased significantly all hematological indices (P < 0.05), except leucocytes and mean corpuscular hemoglobin concentration (MCHC), compared to the control group (P > 0.05). GA3 exposure increased significantly the percentage of nuclear abnormalities, altered erythrocytes and the percentages of tail DNA, compared to the control group (P < 0.05). Spirulina supplementation restored the hematological, poikilocytosis, nuclear abnormalities, and the percentages of tail DNA to near normal levels. The 100 g/kg SP treatment was the most effective in attaining such effect, showing concentration-dependency. The present study reinforces our findings of the toxicity of GA3 on O. niloticus and suggests that the addition of Spirulina to fish diet can mitigate the hemotoxic effects of GA3.
Learning from biological attachment devices: applications of bioinspired reversible adhesive methods in robotics
Authors: Xu Kun , Zi Peijin , Ding Xilun 
Published: November 2022

AbstractMany organisms have attachment organs with excellent functions, such as adhesion, clinging, and grasping, as a result of biological evolution to adapt to complex living environments. From nanoscale to macroscale, each type of adhesive organ has its own underlying mechanisms. Many biological adhesive mechanisms have been studied and can be incorporated into robot designs. This paper presents a systematic review of reversible biological adhesive methods and the bioinspired attachment devices that can be used in robotics. The study discussed how biological adhesive methods, such as dry adhesion, wet adhesion, mechanical adhesion, and sub-ambient pressure adhesion, progress in research. The morphology of typical adhesive organs, as well as the corresponding attachment models, is highlighted. The current state of bioinspired attachment device design and fabrication is discussed. Then, the design principles of attachment devices are summarized in this article. The following section provides a systematic overview of climbing robots with bioinspired attachment devices. Finally, the current challenges and opportunities in bioinspired attachment research in robotics are discussed.
Datenschutzgerechte Wege zur Nutzung von Real World Data
Authors: Drepper Johannes 
Published: November 2022

Zusammenfassung
Hintergrund
Die Nachnutzung vorhandener realweltlicher Daten wird als vielversprechende, die Durchführung klassischer Studien ergänzende Methode der medizinischen Forschung angesehen. Real World Data werden in sehr unterschiedlichen Situationen erhoben und unterliegen damit auch datenschutzrechtlich heterogenen Rahmenbedingungen.

Ziel der Arbeit
Ziel der Arbeit ist die Unterstützung der datenschutzgerechten Nutzung von Real World Data.

Material und Methoden
Neben dem allgemeinen Datenschutzrecht auf europäischer, nationaler und bundeslandspezifischer Ebene werden auch für Gesundheitsdaten spezifische Rechtsgebiete wie die ärztliche Schweigepflicht oder das Sozialrecht beleuchtet. Schutzmethoden wie die Pseudonymisierung und Anonymisierung werden untersucht und eingeordnet.

Ergebnisse
Die Verarbeitung von Real World Data führt im Regelfall zur Anwendung des Datenschutzrechts. Die Klärung der datenschutzrechtlichen Verantwortlichkeit kann bei komplexen Verbundvorhaben anspruchsvoll sein. Die Art der möglichen Rechtsgrundlage für die Verarbeitung hängt von spezifischen Rahmenbedingungen sowie der Art der Verarbeitung ab. Zudem sind die Daten während der Verarbeitung durch technische und organisatorische Maßnahmen zu schützen.

Schlussfolgerung
Die datenschutzrechtlichen Rahmenbedingungen für die Verarbeitung von Real World Data sind komplex. Eine Vereinfachung und Harmonisierung wurde mit der europäischen Datenschutz-Grundverordnung nicht einmal innerhalb Deutschlands erreicht. Bestimmte Wege zur Nutzung dieser Daten, z. B. auf Basis eines „broad consent“ oder mit Hilfe einer abgestimmten Bewertung gemäß einer Forschungsklausel, sind mit viel Aufwand verbunden und stehen damit im Regelfall nur größeren Projekten oder Infrastrukturen zur Verfügung.
Selbstwirksamkeit von Lehrpersonen bei der Entwicklung einer personalisierten Lehr-Lernkultur
Authors: Florin Margaretha , Stebler Rita , Pauli Christine , Reusser Kurt 
Published: November 2022

ZusammenfassungIn diesem Beitrag wird die Bedeutung der Selbstwirksamkeit von Lehrpersonen bei der Entwicklung einer personalisierten Lehr-Lernkultur untersucht. Die Auswertung der längsschnittlich erhobenen Fragebogendaten von 188 Lehrpersonen aus 42 Primar- und Sekundarschulen mittels Skalen- und Korrelationsanalysen sowie auto-regressiven Modellen ergibt folgende Hauptbefunde: Die Lehrpersonen schätzen ihre Selbstwirksamkeit in Bezug auf Unterrichtsentwicklung zu personalisiertem Lernen in drei aufeinanderfolgenden Schuljahren jeweils hoch ein. Ihre hohe Selbstwirksamkeit lässt sich auf personale (Enthusiasmus, Identifikation mit der Schule), nicht aber auf subjektiv wahrgenommene Kontextfaktoren (Kollektive Selbstwirksamkeit, Schulklima, Innovationsklima) zurückführen und hängt positiv mit rückblickend berichteten lehr- und lernseitigen Veränderungen zusammen. Die Ergebnisse der Studie zeigen, dass die Selbstwirksamkeit der Lehrpersonen auch bei der Unterrichtsentwicklung zu personalisiertem Lernen eine nicht zu unterschätzende Rolle spielt und daher empirisch genauer beleuchtet und in der Entwicklungspraxis beachtet werden sollte.
Effects of hormonal treatment on dermatological outcome in transgender people: a multicentric prospective study (ENIGI)
Authors: Cocchetti C. , Castellini G. , Maggi M. , Romani A. , Vignozzi L. , Greenman Y. , den Heijer M. , T’Sjoen G. , Fisher A. D. 
Published: November 2022

Abstract
Purpose
The aim of our study was to assess dermatological changes in transgender people after the start of gender-affirming hormonal treatment (GAHT) and to investigate whether various hormonal preparations differently affect dermatological changes in trans AFAB (assigned female at birth) people.

Methods
In a multicenter prospective study, 484 participants (193 assigned male at birth/AMAB and 291 AFAB) were evaluated at baseline (T0), 6 (T1) and 12 months (T2) after the start of GAHT. Hair growth was assessed by the Ferriman–Gallwey (FG) score, acne by the Global Acne Grading Scale (GAGS), and alopecia by the Norwood Hamilton (NH) score.

Results
In AFAB people, a significant increase in FG score and NH grade was observed across time, as well as in GAGS score in a subsample of 71 individuals (p < 0.001). Testosterone (T) undecanoate and esters showed a higher increase in hair distribution at T2 vs. T1 as compared to T gel (p < 0.01). T esters showed a significantly higher impact in GAGS score modifications at T1 and at T2 vs. T0 compared to T gel (p = 0.021 and p = 0.003, respectively). In trans AMAB people, a significant decrease of FG score was observed across time (p < 0.001), although 51.3% of individuals still reported an FG score higher than eight after 12 months.

Conclusion
T treatment increased hair growth, acne and alopecia prevalence in AFAB people, with T undecanoate and esters influencing hair growth more than T gel. Opposite dermatological changes were observed in AMAB people.