bluuebunny/crossref_metadata_2025_split huggingface dataset:
Removal of iron and manganese from groundwater sources using nano-biosorbents
Authors: Akbari Zadeh Mohammad , Daghbandan Allahyar , Abbasi Souraki Behrouz 
Published: January 2022

Abstract
Background
The presence of iron (Fe) and manganese (Mn) ions in rocky beds leads to groundwater pollution. Moreover, their excessive concentration causes bad taste and color stains of water.

Methods
Tea leaves-derived char (TLC), rice straw-derived char (RSC), and nanosilica (NS) were used to adsorb Fe and Mn ions from water sources. The effects of parameters such as contact time, composition percentage, and particle size of biosorbents in a fixed-bed adsorption column were investigated.

Results
The study on the adsorption of Fe and Mn ions showed that the amount of adsorption increased significantly by decreasing the particle size. Furthermore, the combination of nano-biosorbents with nanosilica improved the adsorption. The Thomas and Adams–Bohart models adequately indicated the adsorption of Fe and Mn ions onto nano-biosorbents in the column mode. The TLC and RSC with NS are applicable for the removal of Fe and Mn ions from groundwater.

Conclusions
According to the BET analysis results, with more crushing of biosorbents by ball mill and placing them in the furnace, specific surface area of tea leaves and rice straw increased from 0.29 to 3.45 and from 3.70 to 10.99 m2/g, respectively. The absorption of iron and manganese from the aqueous solution increased with the percentage of nano-silica. According to breakthrough curves, under best conditions (the seventh mode), nano-biosorbents could remove 98.05% and 97.92% of iron and manganese ions, respectively. The maximum equilibrium capacity of the adsorption column (mg/g) was 256.56 for iron and 244.79 for manganese.

Graphical abstract
ADHD Prescription Medications and Their Effect on Athletic Performance: A Systematic Review and Meta-analysis
Authors: Berezanskaya Jenny , Cade William , Best Thomas M. , Paultre Kristopher , Kienstra Carolyn 
Published: January 2022

Abstract
Background
Stimulant medications used for the treatment of Attention Deficit-Hyperactivity Disorder (ADHD) are believed to provide a physical advantage in athletics, but several of these medications are not regulated by the World Anti-Doping Association. Given the prevalence of ADHD among the athlete population and concern for abuse of ADHD medications, this review and meta-analysis aimed to evaluate effects of ADHD medications on athletic performance, thereby appraising the validity of claims of performance enhancement.

Methods
A search of MEDLINE, Embase, CINAHL, and Cochrane Review databases was performed for all randomized controlled trials evaluating athletic performance after ingestion of placebo or ADHD treatment medications from August 2020 through November 2020. All RCTs identified from these search criteria were included for screening, with exclusion of any animal studies. Two reviewers (JB, CK) assessed methodological quality and risk of bias using CONSORT 2010 and Cochrane Collaboration tools. Study results were compiled with corresponding p values for each finding. Effect sizes (Cohen’s D) for athletic performance and physiological changes were aggregated for each study. Studies were further screened for homogeneity that would allow for meta-analysis. Heterogeneity was calculated using I2.

Results
A total of 13,033 abstracts evaluating amphetamine, methamphetamine, methylphenidate, and bupropion were screened. The final analysis included nine studies, six of which found significant improvement in athletic performance with use of stimulant medications (p < 0.05). Methylphenidate and amphetamine were consistently identified to have a performance effect. Secondary effects identified included significant increase in heart rate, core temperature, and elevation of various serum hormone levels (p < 0.05). Effect size evaluation found seven studies demonstrating small to large effects on physical performance, as well as in categories of cardiometabolic, temperature, hormone, and ratings of perceived exertion, to varying degrees. A meta-analysis was performed on two studies, demonstrating conflicting results.

Conclusions
Dopaminergic/noradrenergic agonist medications appear to have a positive effect on athletic performance, as well as effects on physiological parameters. Further consideration of medications currently not regulated, i.e. bupropion, is warranted given evidence of athletic performance enhancement.
PROSPERO trial registration number: CRD42020211062; 10/29/2020 retrospectively registered.
Frequent tracheal suctioning is associated with extubation failure in patients with successful spontaneous breathing trial: a single-center retrospective cohort study
Authors: Haruna Junpei , Tatsumi Hiroomi , Kazuma Satoshi , Sasaki Aki , Masuda Yoshiki 
Published: January 2022

Abstract
Background
Extubation failure, i.e., reintubation in ventilated patients, is a well-known risk factor for mortality and prolonged stay in the intensive care unit (ICU). Although sputum volume is a risk factor, the frequency of tracheal suctioning has not been validated as a predictor of reintubation. We conducted this study to examine whether frequent tracheal suctioning is a risk factor for reintubation.

Patients and methods
We included adult patients who were intubated for > 72 h in the ICU and extubated after completion of spontaneous breathing trial (SBT). We compared the characteristics and weaning-related variables, including the frequency of tracheal suctioning between patients who required reintubation within 24 h after extubation and those who did not, and examined the factors responsible for reintubation.

Results
Of the 400 patients enrolled, reintubation was required in 51 (12.8%). The most common cause of reintubation was difficulty in sputum excretion (66.7%). There were significant differences in sex, proportion of patients with chronic kidney disease, pneumonia, ICU admission type, the length of mechanical ventilation, and ICU stay between patients requiring reintubation and those who did not. Multivariate analysis showed frequent tracheal suction (> once every 2 h) and the length of mechanical ventilation were independent factors for predicting reintubation.

Conclusion
We should examine the frequency of tracheal suctioning > once every 2 h in addition to the length of mechanical ventilation before deciding to extubate after completion of SBT in patients intubated for > 72 h in the ICU.
Path dependency when prioritising disaster and humanitarian response under high levels of conflict: a qualitative case study in South Sudan
Authors: Mena Rodrigo , Hilhorst Dorothea 
Published: January 2022

AbstractIn high-conflict scenarios, humanitarian needs often surpass resources, and humanitarians are faced with ongoing challenges of whom to prioritise and where to work. This process is often referred to as ‘targeting’, but this article uses the concept of ‘triage’ to emphasise how prioritisation is a continuous and political process, rather than a one-off exercise to find the best match between needs and programme objectives. This study focused on South Sudan, exploring the formal and informal dynamics at the national, regional and local levels of humanitarian decisions. The article is based on semi-structured interviews and multiple meetings and observations of programmes over four months of fieldwork in 2017. This fieldwork was beset by many of the problems that humanitarians also encounter in their work, including complicated access, logistics difficulties and security challenges. Humanitarian action is meant to be flexibly deployed to respond to priority needs resulting from conflict or disasters, and agencies have multiple tools and policies to facilitate this. However, in reality, we find humanitarian action largely locked into path-dependent areas of intervention because agencies must rely on logistics, trust and local partners, all of which take years to develop, and because local actors’ commitment to see programmes continued.
Generalization enhancement of artificial neural network for turbulence closure by feature selection
Authors: Zhu Linyang , Zhang Weiwei , Tu Guohua 
Published: January 2022

AbstractFeature selection targets for selecting relevant and useful features, and is a vital challenge in turbulence modeling by machine learning methods. In this paper, a new posterior feature selection method based on validation dataset is proposed, which is an efficient and universal method for complex systems including turbulence. Different from the priori feature importance ranking of the filter method and the exhaustive search for feature subset of the wrapper method, the proposed method ranks the features according to the model performance on the validation dataset, and generates the feature subsets in the order of feature importance. Using the features from the proposed method, a black-box model is built by artificial neural network (ANN) to reproduce the behavior of Spalart-Allmaras (S-A) turbulence model for high Reynolds number (Re) airfoil flows in aeronautical engineering. The results show that compared with the model without feature selection, the generalization ability of the model after feature selection is significantly improved. To some extent, it is also demonstrated that although the feature importance can be reflected by the model parameters during the training process, artificial feature selection is still very necessary.
Unexplored Functions of Sex Hormones in Glioblastoma Cancer Stem Cells
Authors: Lee Juyeun , Troike Katie , Fodor R’ay , Lathia Justin D 
Published: January 2022

Abstract
Biological sex impacts a wide array of molecular and cellular functions that impact organismal development and can influence disease trajectory in a variety of pathophysiological states. In nonreproductive cancers, epidemiological sex differences have been observed in a series of tumors, and recent work has identified previously unappreciated sex differences in molecular genetics and immune response. However, the extent of these sex differences in terms of drivers of tumor growth and therapeutic response is less clear. In glioblastoma (GBM), the most common primary malignant brain tumor, there is a male bias in incidence and outcome, and key genetic and epigenetic differences, as well as differences in immune response driven by immune-suppressive myeloid populations, have recently been revealed. GBM is a prototypic tumor in which cellular heterogeneity is driven by populations of therapeutically resistant cancer stem cells (CSCs) that underlie tumor growth and recurrence. There is emerging evidence that GBM CSCs may show a sex difference, with male tumor cells showing enhanced self-renewal, but how sex differences impact CSC function is not clear. In this mini-review, we focus on how sex hormones may impact CSCs in GBM and implications for other cancers with a pronounced CSC population. We also explore opportunities to leverage new models to better understand the contribution of sex hormones vs sex chromosomes to CSC function. With the rising interest in sex differences in cancer, there is an immediate need to understand the extent to which sex differences impact tumor growth, including effects on CSC function.
Fathers' Multiple-Partner Fertility and Children's Educational Outcomes
Authors: Ginther Donna K. , Grasdal Astrid L. , Pollak Robert A. 
Published: January 2022

AbstractFathers' multiple-partner fertility (MPF) is associated with substantially worse educational outcomes for children. We focus on children in fathers' second families that are nuclear: households consisting of a man, a woman, their joint children, and no other children. We analyze outcomes for almost 75,000 Norwegian children, all of whom lived in nuclear families until at least age 18. Children with MPF fathers are more likely than other children from nuclear families to drop out of secondary school (24% vs. 17%) and less likely to obtain a bachelor's degree (44% vs. 51%). These gaps remain substantial—at 4 and 5 percentage points, respectively—after we control for child and parental characteristics, such as income, wealth, education, and age. Resource competition with the children in the father's first family does not explain the differences in educational outcomes. We find that the association between a father's previous childless marriage and his children's educational outcomes is similar to that between a father's MPF and his children's educational outcomes. Birth order does not explain these results. This similarity suggests that selection is the primary explanation for the association between fathers' MPF and children's educational outcomes.
Supply chain logistics – the role of the Golgi complex in extracellular matrix production and maintenance
Authors: Hellicar John , Stevenson Nicola L. , Stephens David J. , Lowe Martin 
Published: January 2022

ABSTRACT
The biomechanical and biochemical properties of connective tissues are determined by the composition and quality of their extracellular matrix. This, in turn, is highly dependent on the function and organisation of the secretory pathway. The Golgi complex plays a vital role in directing matrix output by co-ordinating the post-translational modification and proteolytic processing of matrix components prior to their secretion. These modifications have broad impacts on the secretion and subsequent assembly of matrix components, as well as their function in the extracellular environment. In this Review, we highlight the role of the Golgi in the formation of an adaptable, healthy matrix, with a focus on proteoglycan and procollagen secretion as example cargoes. We then discuss the impact of Golgi dysfunction on connective tissue in the context of human disease and ageing.
Regular and App-Enhanced Maintenance of Physical Activity among Latinas: A Feasibility Study
Authors: Mendoza-Vasconez Andrea S. , Solis Becerra Esther , Badii Nathaniel , Crespo Noe , Hurst Samantha , Larsen Britta , Marcus Bess H. , Arredondo Elva M. 
Published: January 2022

ABSTRACT

Introduction
Few studies have focused on physical activity (PA) maintenance, particularly among minority populations; smartphone apps could provide valuable tools. This study aimed to 1) assess and understand PA maintenance among Latinas who completed a PA intervention, and 2) evaluate the feasibility, acceptability, and preliminary efficacy of commercial smartphone apps as tools for PA maintenance.

Methods
For this feasibility study, 27 Latinas who completed a PA intervention and increased their PA were randomly assigned to enhanced maintenance (i.e., taught to use commercial smartphone apps, n = 14) or regular maintenance (i.e., no additional treatment, n = 13). After 3 months, the feasibility and acceptability of using apps for PA maintenance was assessed via survey questions, analyzed using descriptive statistics. PA was reassessed via the 7-d PA recall and analyzed using longitudinal mixed effects regression models. Qualitative data were collected via open-ended interview questions and analyzed using thematic analysis.

Results
Forty-three percent of enhanced maintenance participants reported using study apps at least “a little” and 21% using them “a lot.” Although not statistically significant, enhanced maintenance participants reported a smaller drop in PA from postintervention to postmaintenance, compared with regular maintenance participants. Several participants expressed approval of the apps, whereas others reported on factors that kept them from using the apps for PA maintenance.

Conclusions
Incorporating lessons learned from this study, larger randomized trials are warranted to evaluate the efficacy of using smartphone apps to support PA maintenance. The widespread use of apps could make them ideal tools to support PA maintenance after interventions in different settings.
The post-pandemic era: will physical distancing be a perceived way of life?
Authors: Khan Soban Qadir , Al-Humaid Jehan , Farooqi Faraz Ahmed , Gad Mohammed M. , Al-Hareky Muhanad , Al-Onaizan Faisal , Al-Harbi Fahad A. 
Published: January 2022

Background: This study aimed to determine whether people living in the Eastern Region of Saudi Arabia would prefer to continue the practice of physical distancing after the coronavirus disease 2019 (COVID-19) pandemic or to return to their previous way of life. Methods: This cross-sectional study was conducted from August 2020 to October 2020 in the Eastern Region of Saudi Arabia. A pre-tested questionnaire was sent electronically through social media. Data on participants’ demographics and their perspectives regarding post-pandemic physical distancing were collected. The calculated sample size was 1,066; however, the total number of responses included in the analysis was 989. Results: The average age of the participants was 31.15±11.93 years. There were 435 men and 554 women in the study. Participants showed significantly high levels of disagreement with statements indicating that they were willing to use public transportation (61%), attend social gatherings (36%), and hug relatives or colleagues (40%) after the pandemic (p<0.001); however, 43% agreed that they would spend time with family or friends (p<0.001). The level of education was also found to be significantly related to the responses, and the level of disagreement increased as the level of education increased (p<0.001). Conclusions: One-third of the study participants planned to continue engaging in physical distancing even after the current pandemic and if the COVID-19 related restriction will remain in place for longer, there is chance to increase in this proportion. However, it cannot be concluded whether or not this behavior will prevail in the long run, after the ease in restrictions. If so, it may greatly affect some businesses and perhaps some social norms and values as well.
Causes and consequences of psychological stress in the working life and emergency services of veterinary professionals in the Federal Republic of Germany: A protocol for a nationwide cross-sectional study
Authors: Böckelmann Irina , Pohl Robert , Darius Sabine , Thielmann Beatrice 
Published: January 2022

Background: Veterinarians are exposed to high workloads. International studies show they have an above-average risk of suicide and burnout. Hardly any studies dealing with causes and consequences of workload and emergency services are available in Germany. Methods: The aim of the observational cross-sectional study presented here is to assess their workloads and working conditions (Slesina questionnaire), health situation and well-being (KÖPS questionnaire - physical, psychological and social symptoms; Maslach Burnout Inventory MBI-GS; WHO-5 well-being index), as well as occupational psychological aspects (irritation scales; overcommitment; questionnaire on work-related behavior and experience patterns AVEM) which will be recorded and analyzed according to general sociodemographic and occupational data (sector-, gender, assignment- and country-specific). In addition, the heart rate variability of some members of the veterinary profession will be analyzed using 24 hour electrocardiogram recordings, which together with the subjective insights into the stress situation from the questionnaires, will allow objective psychophysiological stress analyses. Conclusions: The results of the study will provide further empirical insights into the workloads and stresses faced by the veterinary profession in Germany, based on which important insights into this professional group’s mental health can be identified. In this way, it should be possible to identify (mis)stress-triggering factors in the target groups, derive target group-specific recommendations for health-promoting work design, and identify approaches to veterinary studies and career selection.
The impact of innovation on the development of hotel and restaurant enterprises
Authors: Lopatiuk R. 
Published: January 2022

The article analyzes the dynamics and development of innovations in service industry. It was found that innovations are a huge incentive for the further development of the hotel business; which contributes to meet world standards of hotel services. The article substantiates the need to introduce innovations in domestic hotel enterprises in order to reach a larger number of potential consumers of hotel and restaurant product.
Based on the study, the author draws conclusions about the feasibility of using innovation as an important tool for the hotel enterprises development. It is generalized that the use of new technologies of investment process management in the hotel and restaurant business at the present stage of economic development is an important task, which is of great interest to managers of enterprises in this field.
Experimentation and Start-up Performance: Evidence from A/B Testing
Authors: Koning Rembrand , Hasan Sharique , Chatterji Aaron 
Published: January 2022

Recent scholarship argues that experimentation should be the organizing principle for entrepreneurial strategy. Experimentation leads to organizational learning, which drives improvements in firm performance. We investigate this proposition by exploiting the time-varying adoption of A/B testing technology, which has drastically reduced the cost of testing business ideas. Our results provide the first evidence on how digital experimentation affects a large sample of high-technology start-ups using data that tracks their growth, technology use, and products. We find that, although relatively few firms adopt A/B testing, among those that do, performance improves by 30%–100% after a year of use. We then argue that this substantial effect and relatively low adoption rate arises because start-ups do not only test one-off incremental changes, but also use A/B testing as part of a broader strategy of experimentation. Qualitative insights and additional quantitative analyses show that experimentation improves organizational learning, which helps start-ups develop more new products, identify and scale promising ideas, and fail faster when they receive negative signals. These findings inform the literatures on entrepreneurial strategy, organizational learning, and data-driven decision making. This paper was accepted by Toby Stuart, entrepreneurship and innovation.
Dynamic Pricing for New Products Using a Utility-Based Generalization of the Bass Diffusion Model
Authors: Cosguner Koray , Seetharaman P. B. (Seethu) 
Published: January 2022

The Bass Model (BM) has an excellent track record in the realm of new product sales forecasting. However, its use for optimal dynamic pricing or advertising is relatively limited because the Generalized Bass Model (GBM), which extends the BM to handle marketing variables, uses only percentage changes in marketing variables, rather than their actual values. This restricts the GBM’s prescriptive use, for example, to derive the optimal price path for a new product, conditional on an assumed launch price, but not the launch price itself. In this paper, we employ a utility-based extension of the BM, which can yield normative prescriptions regarding both the introductory price and the price path after launch, for the new product. We offer two versions of this utility-based diffusion model, namely, the Bass-Gumbel Diffusion Model (BGDM) and the Bass-Logit Diffusion Model (BLDM), the latter of which has been previously used. We show that both the BGDM and BLDM handily outperform the GBM in forecasting new product sales using empirical data from four product categories. We discuss how to estimate the BGDM and BLDM in the absence of past sales data. We compare the optimal pricing policy of the BLDM with the GBM and derive optimal pricing policies that are implied by the BLDM under various ranges of model parameters. We illustrate a dynamic pricing approach that allows managers to derive optimal marketing policies in a computationally convenient manner and extend this approach to a competitive, multiproduct case.This paper was accepted by Gui Liberali, Management Science Special Section on Data-Driven Prescriptive Analytics.