bluuebunny/crossref_metadata_2025_split huggingface dataset:
Applying concepts from “rapid” and “agile” implementation to advance implementation research
Authors: Quanbeck Andrew , Hennessy Rose Garza , Park Linda 
Published: November 2022

Abstract

Background
The translation of research findings into practice can be improved to maximize benefits more quickly and with greater flexibility. To expedite translation, researchers have developed innovative approaches to implementation branded as “rapid” and “agile” implementation. Rapid implementation has roots in precision medicine and agile implementation has roots in systems engineering and software design. Research has shown that innovation often derives from learning and applying ideas that have impacted other fields.

Implications for implementation researchers
This commentary examines “rapid” and “agile” approaches to implementation and provides recommendations to implementation researchers stemming from these approaches. Four key ideas are synthesized that may be broadly applicable to implementation research, including (1) adopting a problem orientation, (2) applying lessons from behavioral economics, (3) using adaptive study designs and adaptive interventions, and (4) using multi-level models to guide implementation. Examples are highlighted from the field where researchers are applying these key ideas to illustrate their potential impact.

Conclusions
“Rapid” and “agile” implementation approaches to implementation stem from diverse fields. Elements of these approaches show potential for advancing implementation research, although adopting them may entail shifting scientific norms in the field.
Business climate and firm exit in developing countries: evidence from Nigeria
Authors: Orjiakor Ebuka Christian 
Published: November 2022

AbstractThe business environment goes a long way to influence firm performance through several channels such as government policies and regulations, institutions, infrastructure, and macroeconomic variations. With developing countries known for having the most deteriorating business climate, this study set out to answer the question: "Does business climate account for firm exit in developing countries?" Using a comprehensive dataset of panel firms from the World Bank Enterprise Survey in Nigeria, the study aggregates 15 firm-level constraint variables into a composite index and estimates the likelihood of firm exit using the binary probit model. The results from the analysis infer that the unconducive state of the business climate in Nigeria significantly impedes firms’ prospects for survival. More specifically, the estimated probability of exiting the market is predicted to grow by 11% points for every additional increase in the constraint index. The recommendation follows that efforts should be geared toward improving the state of the business climate in Nigeria through carefully designed policies that can foster private sector development. Such policies should among others increase government investment in critical infrastructure, eliminate destructive tax policies, and maintain a healthy macroeconomic environment, which by implication, go a long way to improve business longevity and contributes to national development.
Insights Into the Role of DNA Methylation and Gene Expression in Graves Orbitopathy
Authors: Rotondo Dottore Giovanna , Lanzolla Giulia , Comi Simone , Menconi Francesca , Mencacci Lodovica Cristofani , Dallan Iacopo , Marcocci Claudio , Marinò Michele 
Published: November 2022

AbstractContextA role of DNA methylation in Graves orbitopathy (GO) has been proposed.ObjectiveThis work aimed to investigate DNA methylation and gene expression in orbital fibroblasts from control and GO patients, under basal conditions or following challenge with an anti- thyrotropin (TSH) receptor antibody (M22) or cytokines involved in GO; to investigate the relationship between DNA methylation and cell function (proliferation); and to perform a methylome analysis.MethodsOrbital fibroblasts from 6 GO and 6 control patients from a referral center underwent methylome analysis of the whole genome.ResultsGlobal DNA methylation increased significantly both in control and GO fibroblasts on incubation with M22. Expression of 2 selected genes (CYP19A1 and AIFM2) was variably affected by M22 and interleukin-6. M22 increased cell proliferation in control and GO fibroblasts, which correlated with global DNA methylation. Methylome analysis revealed 19 869 DNA regions differently methylated in GO fibroblasts, encompassing 3957 genes and involving CpG islands, shores, and shelves. A total of 119 gene families and subfamilies, 89 protein groups, 402 biological processes, and 7 pathways were involved. Three genes found to be differentially expressed were concordantly hypermethylated or hypomethylated. Among the differently methylated genes, insulin-like growth factor-1 receptor and several fibroblast growth factors and receptors were included.ConclusionWe propose that, when exposed to an autoimmune environment, orbital fibroblasts undergo hypermethylation or hypomethylation of certain genes, involving CpG promoters, which results in differential gene expression, which may be responsible for functional alterations, in particular higher proliferation, and ultimately for the GO phenotype in vivo.
Depression and suicide risk in dermatological diseases - a review of the literature
Authors: Hordejuk Michalina , Marczak Aleksandra , Szymkiewicz Karolina , Hyjek Michał 
Published: November 2022

Introduction
Depression can be an independent disease entity, but can also result from other somatic diseases. Psychodermatology is a scientific field that deals with the interactions between dermatology and psychiatry and psychology. It is estimated that psychiatric disorders may co-occur in up to 30-60% of people with dermatological conditions. Mood disorders of the depressive type are most common among this group of patients [1]. It is important that skin specialists pay attention to the mental state of their patients in their daily practice.
Objective
In our work, we would like to draw attention to the interplay between psychiatric and dermatological diseases.
Methods
A literature search was performed in the PubMed medical publication database using the following keywords: depression; dermatology; skin; somatic; psychiatry; psoriasis; atopic dermatitis; acnes vulgaris; suicidal risk.
Results
There is a proven risk of depression in patients with psoriasis, acne and atopic dermatitis. These diseases also increase the risk of suicidal thoughts.
Conclusions
Awareness among professionals and patients of the co-occurrence of these disorders is insufficient, which in some cases can lead to serious consequences for the patient and affect the effectiveness of treatment of both dermatological and psychiatric disorders.
Biochemical profile, antioxidant effect and antifungal activity of Saudi Ziziphus spina-christi L. for vaginal lotion formulation
Authors: Hallouma Bilel , Hani Mohamed Awad Abdelzaher , Shaima Mohamed Nabil Moustafa 
Published: November 2022

Ziziphus spina-christi L. extract from the northern region of Saudi Arabia, was investigated to determine its chemical composition and to evaluate its antioxidant and antifungal properties. Fresh leaves were extracted using Soxhlet apparatus and the yield was 8% w/w. Results of the qualitative study showed that this extract is rich in chemical compounds belonging to several classes (saponins, phenols, tannins). GC-MS analysis detected 38 chemical compounds with different concentrations representing 99.71 % of the total extract. However, Z. spina-christi leaves extract is mainly composed of Octadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethylester (18.80%). The extract has free radical scavenging activity at different concentrations and the best result was obtained with IC50 of 148.33 µg/ml. C. albicans and other Candida species caused vulvovaginal candidiasis, which is a high-risk occurrence in hospitalized patients. In vitro antifungal activity was investigated by the agar well diffusion test to measure and compare diameter of zones of inhibition (in mm) against Candida albicans, Candida glabrata and Candida tropicalis. Ethanolic extract of Z. spina-christi demonstrated a substantial inhibitory impact on several Candida species, especially against C. glabrata which has the highest inhibitory effect (90%). Therefore, Saudi Z. spina-christi leaves extract is a source of natural antioxidants and it can be used as well antifungal pharmaceutical product.
A general method to study the convergence of nonlinear operators in Orlicz spaces
Authors: Vinti Gianluca , Zampogni Luca 
Published: November 2022

AbstractWe continue the work started in a previous article and introduce a general setting in which we define nets of nonlinear operators whose domains are some set of functions defined in a locally compact topological group. We analyze the behavior of such nets and detect the fairest assumption, which are needed for the nets to converge with respect to the uniform convergence and in the setting of Orlicz spaces. As a consequence, we give results of convergence in this frame, study some important special cases, and provide graphical representations.
Boosting the photocatalytic performance of the oligo (phenylene vinylene) moiety by copolymerization for the heterogeneous degradation of indigo carmine dye
Authors: Acelas Mauricio , Pérez León D. , Sierra César A. 
Published: November 2022

Abstract
The copolymerization with flexible and rigid spacers of 4,4’-((1E, 1′E)-(2,5-dimethoxy-1,4-phenylene)bis (ethene-2,1-diyl))dibenzoic acid, as a promising phenylene vinylene-based (PV) organic photocatalyst, was examined as a strategy to validate the effect of such chemical modifications in the modulation of the photocatalytic properties of this organic π-conjugated moiety. The polymers prepared here were fully characterized and evaluated as photocatalysts in the degradation of indigo carmine dye under two different irradiation scenarios (UVA and visible), consistently displaying a superior efficiency in contrast to their monomeric oligo (phenylene vinylene) (OPV) counterparts. Scavenging experiments confirmed that photocatalysis proceeds via the generation of superoxide radicals (O2
•–), singlet oxygen (1O2), and direct oxidation. The obtained results proved that the insertion of an aromatic rigid spacer not only prompts an enhancement in the photocatalytic activity of the phenylene vinylene-based polymers but also increases the stability of the OPV moiety by minimizing the reaction of the vinyl fragments with reactive oxygen species. This was demonstrated with the reuse experiments, where 96% of the photocatalytic activity was preserved throughout the first five reuse cycles.
Formulating calcium carbonate masterbatches
Authors: Radebe Lucky , Wesley-Smith James , Focke Walter W. , Ramjee Shatish 
Published: November 2022

Abstract
The effects of filler content, filler particle size and surface coating, as well as the natures of the wax and metal stearate lubricants on the properties of calcium carbonate-filled linear low-density polyethylene compounds were investigated. The elongation at break decreased exponentially with filler loading irrespective of whether the filler was surface coated or not. The corresponding decline in the impact strength was more gradual but it dropped abruptly on reaching a filler loading of 70 wt%. The effect of shear rate on the apparent melt viscosity followed an empirically modified Carreau–Yasuda model which included the effect of filler content. It features the zero-shear viscosity and the flow consistency index as adjustable parameters. These characterize the viscosity trends at low- and high-shear rates, respectively. In the absence of additives, the melt viscosity at 60 wt% filler exceeded that of the neat polymer by a factor of three. Adding 3 wt% wax and 1.0 wt% zinc stearate returned the melt viscosity to levels just above that of the neat polymer. Calcium stearate and magnesium stearate were less effective at reducing the apparent melt viscosity but a blend of the latter with zinc stearate performed particularly well.
Im Spannungsfeld von Mehrsprachigkeit und Variantenvielfalt: Sprachpolitische Positionen zum Kroatischen im Burgenland am Beispiel Ignac Horvats
Authors: Tyran Katharina 
Published: November 2022

Summary
Among the Croatian speaking population and their elites in former Western Hungary and later Burgenland, standard written language issues have been debated throughout the 20th century. Various language policy entrepreneurs favored for a convergence with Serbo-Croatian / Croato-Serbian or the common Štokavian standard language, respectively. My article focuses on one such linguistic entrepreneur, Ignac Horvat, who was not a linguist by training, but as a priest, editor and writer one of the leading voices since the interwar period. His language policy articulated in newspaper articles as well as two typewritten and autotyped orthographic compilations vividly shows that minority languages always have to position themselves in a multilingual context and that language policy actors of such “small” languages try to follow the concepts of “bigger” standard languages. His linguistic policy, however, eventually failed and highlights that in standardization processes of minority languages ideologies are often oriented differently, rejecting stigmatization of local forms, but exaggerated emphasizing intelligibility as the main factor for language maintenance.
Linguistic Diversity in East-Central European Minority Literature: The Post-Imperial Borderlands of Petar Milošević
Authors: Vervaet Stijn 
Published: November 2022

Abstract
Most recent studies on multilingual writing deal with literature by first- or second-generation immigrants. This article responds to debates about multilingual literature by examining the asymmetrical, historically-rooted multilingualism of minority groups in East-Central Europe. It does so by exploring linguistic diversity and its effects in the novels of the bilingual Serbian-Hungarian author Petar Milošević, novels that put the Serbian minority in Hungary centre stage. It is argued that Milošević’s prose fiction not only invites the reader to rethink the nature of script, standard language and cultural identity as historically contingent and multiply entangled, but also effectively refashions the cultural memory of the Serbian minority in Hungary. The novels’ broader relevance lies in their foregrounding of the minority’s cultural and linguistic doubleness, both in relation to the nation-state in which they live and to the external homeland. As such, they also potentially illuminate the position of other linguistic minorities in former Habsburg borderlands.
Tradicionalidad discursiva e influencia del francés en la gramaticalización de en definitiva como marcador del discurso
Authors: Llopis Cardona Ana 
Published: November 2022

Abstract
This paper addresses the grammaticalization of Spanish en definitiva as a discourse marker. The objectives are threefold: to enquire about previous changes and discourse traditions that took place, to outline the path to the new values that were acquired, and to ascertain whether the French construction en définitive had an influence on the Spanish one during the grammaticalization process. To do so, we examined the cases found in Frantext for French, while for the Spanish data, we used Corpus del Diccionario histórico de la lengua española and Corpus diacrónico del español. Additionally, Gallica and Hemeroteca Digital were used to fill the gaps in the documentation for the 18th and 19th centuries. The results show that en definitiva might have undergone a vernacular evolution fixing as a ritual formula that gave rise to a modal construction and later assimilated new discourse uses as loan translations from the French construction en définitive. This finding leads to deeper consideration of the evolution of Modern French discourse markers and 19th century Spanish press.
De amor y primavera: el debate entre don Denis y Airas Nunez
Authors: Lorenzo Gradín Pilar 
Published: November 2022

Abstract
Critics have interpreted Don Denis’ cantiga Proençaes soen mui bem trobar as a diatribe directed against Occitan troubadours who associated in their poems springtime exordium and song for love. Although some have considered the particular piece of the Portuguese king an aesthetic recreation of the cansós that rejected the début printanier cliché, in this contribution a different reading is proposed. Given that in the entire corpus of the cantigas de amor there is only one text by the Galician clergyman Airas Nunez (Que muito m’eu pago d’este verão) that unites spring, euphoric love, and lyrical activity, this article argues that Don Denis’ poem emerged as a polemic and ironic response to the eccentric verses of his colleague. From the proposed perspective, the king’s cantiga is contextually situated and understood as part of a series of texts that integrate the king and the clergyman’s metaliterary debate on the conception of love.
Availability and affordability of alcohol and tobacco products for the population: results of a pilot study in the Sverdlovsk Oblast
Authors: Antsiferova A. A. , Kontsevaya A. V. , Mukaneeva D. K. , Popovich M. V. , Gambaryan M. G. , Pustelenin А. V. , Glukhovskaya S. V. , Levina I. A. , Drapkina O. M. 
Published: November 2022

Aim. To analyze the availability and affordability of alcohol and tobacco outlets using the specialized software developed by the National Medical Research Center for Therapy and Preventive Medicine in the pilot subject of the Russian Federation — the Sverdlovsk Oblast.Material and methods. For the first time, experts from the National Medical Research Center for Therapy and Preventive Medicine conducted a pilot study to assess the actual state of the infrastructure of a separate subject of the Russian Federation (Sverdlovsk Oblast). The study objects were the urban infrastructure elements in which alcohol and tobacco products are sold. In order to assess the infrastructure, special software was developed using Open Street Maps to perform data collection tasks. The infrastructure data collection for the pilot study took place from January to March 2022.Results. The total number of tobacco outlets is 299, most of which are located in supermarkets (82,6%, n=247). The share of individual tobacco outlets accounts for 13,7% (n=41). Out of 357 supermarkets, 247 (69%) have tobacco sales section. The average lowest price of a cigarette pack is 121,6±15,7 RUB (minimum — 30 RUB, maximum — 207 RUB). Twentyseven (10,9%) of 247 supermarkets located <100 m from educational institutions carry tobacco products. The minimum distance is 64 m. There are 449 alcohol outlets in total, most of them are located in supermarkets — 57,0% (n=256). Individual alcohol outlets account for 40,8% (n=183). Out of 357 supermarkets, 256 (71,7%) have alcohol sales section. Out of 158 individual alcohol outlets, vodka is available in 101 (63%) outlets, wine — in 112 (68,3%) out of 162 outlets, beer — in 112 (68,3%) out of 164 outlets, alcoholic cocktails — in 71 (45,2%) out of 57 outlets. The average lowest selling price of vodka is 255,9±62,2 RUB (minimum — 230 RUB), wine — 180,2±89,3 RUB (minimum — 110 rubles), beer — 51,2±15,5 RUB (minimum — 33 rubles), alcoholic cocktails — 58,9±15,4 RUB (minimum — 37 rubles). In addition, 27 (10,5%) of 256 supermarkets with a liquor section (minimum distance of 64m) are located <100 m from educational institutions, as well as 10 (5,4%) out of 183 individual stores specializing in the alcohol sale (minimum distance of 50 m).Conclusion. The results obtained with the help of the developed tool can be used as arguments for strengthening monitoring of compliance and making changes to the current legislation that restricts the availability of tobacco and alcohol products. The use of the developed tool will make it possible using evidence to make informed decisions in the development and implementation of public health programs at the municipal level.
Content of matrix metalloproteinases in the blood of hypertensive patients with a high cardiovascular risk receiving statin therapy
Authors: Mikhin V. P. , Osipova O. A. , Vorotyntseva V. V. , Perutsky D. N. , Golovina N. I. 
Published: November 2022

Aim. To compare the effect of atorvastatin and rosuvastatin as part of complex therapy in patients with hypertension (HTN) with a high cardiovascular risk on the level of matrix metalloproteinases -1, -9 (MMP-1, MMP-9) and tissue inhibitors of metalloproteinases -1, -4 (TIMP-1, TIMP-4).Material and methods. The study included 140 hypertensive patients who received atorvastatin (Liprimar) 20 mg/day in addition to antihypertensive therapy for a year, which was later replaced by rosuvastatin (Rosucard) in the following doses: 10 mg/day (n=96), 20 mg/day (n=24), 40 mg/day (n=26). Patients underwent standard clinical and paraclinical investigations. In the blood serum of patients, the levels of MMP-1, MMP-9 and TIMP-1, TIMP-4 were determined.Results. Patients who used rosuvastatin at a dose of 40 mg/day had a more pronounced decrease in MMP-1 than those treated with rosuvastatin at a dose of 10 and 20 mg/day (p<0,05), while there were no differences in MMP-1 when using low and medium doses. Rosuvastatin had a less pronounced effect on MMP-9 than on MMP-1, while increasing the dose of rosuvastatin did not affect the intensity of MMP-9 reduction (p>0,05). The content of TIMP-1 and TIMP-4 increased when taking rosuvastatin, while a more pronounced dose-dependent increase in TIMP-1 was observed with rosuvastatin 20 mg/day and 40 mg/day. In addition, the largest increase in TIMP-4 was observed when using rosuvastatin at a dose of 40 mg/day. Atorvastatin had no significant effect on MMP-1 and MMP-9, as well as TIMP-1 and TIMP-4.Conclusion. Long-term rosuvastatin therapy (10 mg/day, 20 mg/day, 40 mg/day) as part of the complex therapy of cardiovascular patients affects the metabolism of vascular wall elastin and collagen, reducing the level of MMP-1, MMP-9 and increasing the content of TIMP-1, TIMP-4 in the blood.