bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution of host protease interactions among SARS-CoV-2 variants of concern and related coronaviruses
Authors: Kastenhuber Edward R. , Johnson Jared L. , Yaron Tomer M. , Mercadante Marisa , Cantley Lewis C. 
Published: June 2022

AbstractPreviously, we showed that coagulation factors directly cleave SARS-CoV-2 spike and promote viral entry (Kastenhuber et al., 2022). Here, we show that substitutions in the S1/S2 cleavage site observed in SARS-CoV-2 variants of concern (VOCs) exhibit divergent interactions with host proteases, including factor Xa and furin. Nafamostat remains effective to block coagulation factor-mediated cleavage of variant spike sequences. Furthermore, host protease usage has likely been a selection pressure throughout coronavirus evolution, and we observe convergence of distantly related coronaviruses to attain common host protease interactions, including coagulation factors. Interpretation of genomic surveillance of emerging SARS-CoV-2 variants and future zoonotic spillover is supported by functional characterization of recurrent emerging features.
A relational model of university's identity and architectural design pre- and post-pandemic
Authors: Beheiry Dalia A. , Shafik Zeinab , Aboubakr Dalia 
Published: June 2022

PurposeThe present research aims to explore the relationship between the university's new identity and its architectural design, and to investigate the impact of COVID-19 pandemic on this model. It also aims to analyze the declared identity of the new Egyptian universities.Design/methodology/approachTo formulate the hypothesis of the relational model, the research started with the literature related to physical and nonphysical variables of university's identity (organizational and visual identity) and the impact of the pandemic on its identity. Secondly, an online questionnaire targeting academic leaders was conducted to identify the relative importance of the selected variables of university's identity pre- and post-pandemic. Thirdly, a content analysis of the new Egyptian universities' identity was used to track the correlation between the selected variables based on information accessible on universities' websites. Finally, the results of the content analysis and the questionnaire were compared to test the hypothesis.FindingsThe study reveals the most important physical variable of university's new identity pre- and post-pandemic is technological infrastructure and flexible design, while the least important is university's unique design. The results highlight that the universities need to revisit the declared identity to reflect the new challenges posed by COVID-19.Originality/valueThis study is considered one of the first researches that links the physical and nonphysical variables of university's new identity. The current study contributes to analyzing the impact of COVID-19 on university identity and architecture.
Measuring the financial impact of equipment performance improvement: ISB and IEB metrics
Authors: Gólcher-Barguil Luis Alejandro , Nadeem Simon Peter , Garza-Reyes Jose Arturo , Samadhiya Ashutosh , Kumar Anil 
Published: June 2022

PurposeEquipment performance helps the manufacturing sector achieve operational and financial improvements despite process variations. However, the literature lacks a clear index or metric to quantify the monetary advantages of enhanced equipment performance. Thus, the paper presents two innovative monetary performance measures to estimate the financial advantages of enhancing equipment performance by isolating the effect of manufacturing fluctuations such as product mix price, direct and indirect characteristics, and cost changes.Design/methodology/approachThe research provides two measures, ISB (Improvement Saving Benefits) and IEB (Improvement Earning Benefits), to assess equipment performance improvements. The effectiveness of the metrics is validated through a three stages approach, namely (1) experts' binary opinion, (2) sample, and (3) actual cases. The relevant data may be collected through accounting systems, purpose-built software, or electronic spreadsheets.FindingsThe findings suggest that both measures provide an effective cost–benefit analysis of equipment performance enhancement. The measure ISB indicates savings from performance increases when equipment capacity is greater than product demand. IEB is utilised when equipment capacity is less than product demand. Both measurements may replace the unitary cost variation, which is subject to manufacturing changes.Practical implicationsManufacturing businesses may utilise the ISB and IEB metrics to conduct a systematic analysis of equipment performance and to appreciate the financial savings perspective in order to emphasise profitability in the short and long term.Originality/valueThe study introduces two novel financial equipment performance improvement indicators that distinguish the effects of manufacturing variations. Manufacturing variations cause cost advantages from operational improvements to be misrepresented. There is currently no approach for manufacturing organisations to calculate the financial advantages of enhancing equipment performance while isolating production irregularities.
A formative measurement model and development of quality of work-life scale based on two-factor theory: evidence from Indian private industries
Authors: Yadav Radha 
Published: June 2022

PurposeThis study examines the quality of work-life (QoWL) as a formative construct and validates the scale in an Indian context. Taking a cue from the two-factor (Herzberg) theory, the study developed and validated a formative assessment model of QoWL in the current scenario.Design/methodology/approachCross-sectional data and a self-administered questionnaire were used to analyze the QoWL scale based on a sample of 841 respondents from IT/ITES, BFSI, CPG and manufacturing sectors. Indicators/items of QoWL were considered a first-order reflective construct, and factors of QoWL were considered second-order formative construct in the study. Embedded two-stage approach was used to assess the antecedent construct in the model in which QoWL was measured with seven formative indicators in stage one, and all the constructs of the QoWL are measured with a single item (Global_QWL, i.e. the essence of all constructs) in stage two.FindingsThe study found QoWL as a formative construct with seven significant dimensions; namely, hygiene factors included fairness in compensation (FC), job security (JS), interpersonal relationship (IR), health and wellbeing (HWB), where motivational factors had rewards and career growth (RG), work-life balance (WLB) and learning and development (LD). The study also indicated the strong association of a single item (global_QWL) with all constructs of QoWL. The study findings conceptualize a QoWL as a formative construct within the mentioned sector and can be generalized and extended to other sectors of the economy as well.Research limitations/implicationsFuture researchers can take guidance to deal with the formative construct in the development and validation of scale in various topics in the field of HRM. Future researchers can extend the study across cities and different sectors.Practical implicationsIn this VUCA world, employees have to be constantly on their toes to ensure their organization remains relevant. In this context, the least organization can do for their employees is to offer a conducive environment and favorable QoWL. This study aims to assist the key decision-makers in applying the QoWL index as a formative construct and aiding them in improving the quality of their decisions.Social implicationsResearcher believes that applying the QoWL index as a formative construct can aid decision-makers in improving the quality of their decisions by equipping them with relevant inputs and knowledge. Government can focus on the employees' welfare and introduce the current motivational and hygiene factors in the area of quality of life of the Indians.Originality/valueFormative assessment measurement of QoWL model was validated with the two-factor theory to understand the work environment of India in the private sector across different sectors. The unique finding of the study was a single item (global_QWL) to conclude the QoWL index as a formative construct by redundancy analysis.
Preparation of a novel alkanolamine borate and its tribological properties in copper wire drawing oil
Authors: Lang XuJin , Wang Liping , Du Xin , Li Lixia , Zhang Dongya 
Published: June 2022

Purpose
This paper aims to synthesize a novel alkanolamine borate and explore the performance of as a copper wire drawing oil.

Design/methodology/approach
In this paper, a copper wire drawing oil (CU-KL) was formulated by using a novel alkanolamine borate, naphthenic base oil, fatty alcohol polyoxyethylene ether and palm oil. The tribological performance of CU-KL and commercial copper wire drawing oils (CU-DRB and CU-8010) was investigated

Findings
Under applied loads of 5 N-15 N, the average friction coefficient of CU-KL was 29.4%, 5.4% and 25.3% lower than that of CU-DRB, respectively. At sliding speed of 1000–5000 rpm, the average friction coefficient of CU-KL was reduced by 14.3%, 6% and 10.3% compared with CU-DRB, respectively. Through scanning electron microscope and energy dispersive spectrometry, CU-KL can form B-containing compound at the contact interface, which could synergistically enhance the lubrication effect and improve the wear resistance.

Originality/value
The properties of CU-KL under different test condition were studied, and the findings are of great significance for the application of alkanolamine borate in copper wire drawing oil.
Reviewing in a pandemic? A commentary on COVID-19 and domestic homicide review
Authors: Rowlands James 
Published: June 2022

Purpose
This paper is a commentary on COVID-19’s impact on Domestic Homicide Reviews (DHRs), the system in England and Wales that enables learning from domestic abuse-related deaths.

Design/methodology/approach
Drawing on a practitioner–researcher perspective, this paper reflects on how COVID-19 affected the delivery and experience of DHRs, the place of victims at the heart of this process and what the pandemic’s impact might mean moving forward.

Findings
This paper explicates some of the challenges of undertaking DHRs in a pandemic. Critically, however, it argues that these challenges illuminate broader questions about the practice of DHR.

Originality/value
This paper’s originality comes from the author’s practitioner–researcher perspective and its use of COVID-19 as a lens to consider DHRs.
Exploring the changes and challenges of COVID-19 in adult safeguarding practice: qualitative findings from a mixed-methods project
Authors: Pritchard-Jones Laura , Mehmi Monique , Eccleston-Turner Mark , Brammer Alison 
Published: June 2022

Purpose
The purpose of this paper is to present findings from a mixed-methods study on the impact that COVID-19 has had on adult safeguarding. The research sought to explore the challenges and opportunities presented by COVID-19 to both frontline and non-frontline professionals working in adult safeguarding.

Design/methodology/approach
A mixed-methods project was undertaken comprising a literature review, survey, semi-structured interviews and a small number of freedom of information requests. This paper presents the findings predominantly from the survey and interviews.

Findings
Unsurprisingly, COVID-19 has presented a variety of challenges for professionals working in adult safeguarding. The themes that occurred most often were the day-to-day changes and challenges, relationships across sectors, information and navigating the ethical questions in safeguarding.

Originality/value
To the best of the authors’ knowledge, the findings represent the first focused qualitative mixed-method study aimed at understanding more about the impact the pandemic has had on adult safeguarding through the eyes of those professionals working in that field.
Bank regulation and risk-taking in sub-Sahara Africa
Authors: Gondwe Sopani , Gwatidzo Tendai , Mahonye Nyasha 
Published: June 2022

Purpose
In a bid to enhance the stability of banks, supervisory authorities in sub-Sahara Africa (SSA) have also adopted international bank regulatory standards based on the Basel core principles. This paper aims to investigate the effectiveness of these regulations in mitigating Bank risk (instability) in SSA. The focus of empirical analysis is on examining the implications of four regulations (capital, activity restrictions, supervisory power and market discipline) on risk-taking behaviour of banks.

Design/methodology/approach
This paper uses two dimensions of financial stability in relation to two different sources of bank risk: solvency risk and liquidity risk. This paper uses information from the World Bank Regulatory Survey database to construct regulation indices on activity restrictions and the three regulations pertaining to the three pillars of Basel II, i.e. capital, supervisory power and market discipline. The paper then uses a two-step system generalised method of moments estimator to estimate the impact of each regulation on solvency and liquidity risk.

Findings
The overall results show that: regulations pertaining to capital (Pillar 1) and market discipline (Pillar 3) are effective in reducing solvency risk; and regulations pertaining to supervisory power (Pillar 2) and activity restrictions increase liquidity risk (i.e. reduce bank stability).

Research limitations/implications
Given some evidence from other studies which show that market power (competition) tends to condition the effect of regulations on bank stability, it would have been more informative to examine whether this is really the case in SSA, given the low levels of competition in some countries. This study is limited in this regard.

Practical implications
The key policy implications from the study findings are three-fold: bank supervisory agencies in SSA should prioritise the adoption of Pillars 1 and 3 of the Basel II framework as an effective policy response to enhance the stability of the banking system; a universal banking model is more stability enhancing; and there is a trade-off between stronger supervisory power and liquidity stability that needs to be properly managed every time regulatory agencies increase their supervisory mandate.

Originality/value
This paper provides new evidence on which Pillars of the Basel II regulatory framework are more effective in reducing bank risk in SSA. This paper also shows that the way regulations affect solvency risk is different from that of liquidity risk – an approach that allows for case specific policy interventions based on the type of bank risk under consideration. Ignoring this dual dimension of bank stability can thus lead to erroneous policy inferences.
Switching to peer-to-peer accommodation (P2PA): an extended push-pull-mooring model perspective from emerging economy
Authors: Gupta Anil , Mahajan Honeyka , Dogra Nikita , Dogra Ravinder 
Published: June 2022

PurposeDrawing on the Push-Pull-Mooring model, this study sheds light on the factors that drive tourists to switch from traditional hotels to peer-to-peer accommodation (P2PA) in light of the global spread of the Covid-19 pandemic.Design/methodology/approachData have been collected from 380 participants through an online pan India survey. The data were mainly analyzed by adopting structural equation modeling.FindingsAll the three categories of push, pull and mooring factors are crucial in explaining tourists' switching intentions from hotels to P2PA. Out of all the factors, subjective norm came out to be the most significant factor while satiation (push factor) and authentic experiences (pull factor) also came out to be important indicators.Practical implicationsThe findings of this study carry implications for hoteliers as well as P2PA platform hosts. Hotels need to re-conceptualize their standard services, décor and amenities while P2PA hosts need to continue providing authentic experiences and also comply with all the Covid-19 norms.Originality/valueThe study offers a comprehensive PPM model to determine tourists' intentions to switch from hotels to P2PA. Moreover, this paper is one of the early studies to provide insights into tourists' switching intentions amidst Covid-19.
An antibacterial T6SS in Pantoea agglomerans pv. betae delivers a lysozyme‐like effector to antagonize competitors
Authors: Carobbi Andrea , Di Nepi Simone , Fridman Chaya M. , Dar Yasmin , Ben‐Yaakov Rotem , Barash Isaac , Salomon Dor , Sessa Guido 
Published: June 2022

AbstractThe type VI secretion system (T6SS) is deployed by numerous Gram‐negative bacteria to deliver toxic effectors into neighbouring cells. The genome of Pantoea agglomerans pv. betae (Pab) phytopathogenic bacteria contains a gene cluster (T6SS1) predicted to encode a complete T6SS. Using secretion and competition assays, we found that T6SS1 in Pab is a functional antibacterial system that allows this pathogen to outcompete rival plant‐associated bacteria found in its natural environment. Computational analysis of the T6SS1 gene cluster revealed that antibacterial effector and immunity proteins are encoded within three genomic islands that also harbour arrays of orphan immunity genes or toxin and immunity cassettes. Functional analyses indicated that VgrG, a specialized antibacterial effector, contains a C‐terminal catalytically active glucosaminidase domain that is used to degrade prey peptidoglycan. Moreover, we confirmed that a bicistronic unit at the end of the T6SS1 cluster encodes a novel antibacterial T6SS effector and immunity pair. Together, these results demonstrate that Pab T6SS1 is an antibacterial system delivering a lysozyme‐like effector to eliminate competitors, and indicate that this bacterium contains additional novel T6SS effectors.
Patterns of discretionary food intake among Australian children and their association with socio‐demographic, lifestyle, and adiposity measures
Authors: Fayet‐Moore Flavia , McConnell Andrew , Tuck Kate , Petocz Peter , Cassettari Tim , Rahimi‐Ardabili Hania , Blumfield Michelle , Marshall Skye 
Published: June 2022

AbstractAimAustralian children consume 35% of energy from discretionary food and beverages which increases their risk of non‐communicable diseases like type 2 diabetes. Despite this concerning statistic, broad analysis of the profile of discretionary food intake has not been fully undertaken. This study asks: what is the discretionary food and beverage intake profile, contribution to nutrient intakes, and associations with demographic and health characteristics?MethodsCross‐sectional data from the 2011–12 National Nutrition and Physical Activity Survey (n = 2812, 2–18 years) were used to profile discretionary food consumption. Dietary intake was assessed by 24‐h recall. General linear models tested the difference in respondent characteristics by age group, sex, and quartiles of discretionary food energy contribution.ResultsNinety‐nine percent of respondents consumed discretionary foods, 74% exceeded the maximum discretionary food recommended serves. Among 10 eating occasions available to select: snack, dinner, lunch and morning tea appeared to contribute 76% of discretionary food energy, with snack and dinner contributing 24% each. Age and frequency of discretionary food consumption were positively associated with energy intake from discretionary foods (p < 0.001); while sex, socio‐economic status, physical activity and body composition had no association. High discretionary food consumers chose specific discretionary food items in a large quantity (1.0–3.5‐serves/discretionary food) compared to low discretionary food consumers (0.4–1.4‐serves/discretionary food).ConclusionsNearly all Australian children and adolescents consumed discretionary food daily. No demographic or anthropometric characteristics beyond increasing age were associated with higher discretionary food. Targeted public health policy and community interventions are required to focus on addressing the largest contributors to discretionary food intake in terms of equivalent serve sizes, popularity, and eating occasion.
Repurposing chia seed oil: A versatile novel functional food
Authors: Tak Yamini , Kaur Manpreet , Kumar Rajendra , Gautam Chirag , Singh Prabhjot , Kaur Harjeet , Kaur Amanpreet , Bhatia Surekha , Jha Niraj Kumar , Gupta Piyush Kumar , Amarowicz Ryszard 
Published: June 2022

AbstractChia seed oil (CSO) has been recently gaining tremendous interest as a functional food. The oil is rich in with polyunsaturated fatty acids (PUFAs), especially, alpha linolenic acid (ALA), linoleic acid (LA), tocopherols, phenolic acids, vitamins, and antioxidants. Extracting CSO through green technologies has been highly efficient, cost‐effective, and sustainable, which has also shown to improve its nutritional potential and proved to be eco‐friendly than any other traditional or conventional processes. Due to the presence of valuable bioactive metabolites, CSO is proving to be a revolutionary source for food, baking, dairy, pharmaceutical, livestock feed, and cosmetic industries. CSO has been reported to possess antidiabetic, anticancer, anti‐inflammatory, antiobesity, antioxidant, antihyperlipidemic, insect‐repellent, and skin‐healing properties. However, studies on toxicological safety and commercial potency of CSO are limited and therefore the need of the hour is to focus on large‐scale molecular mechanistic and clinical studies, which may throw light on the possible translational opportunities of CSO to be utilized to its complete potential. In this review, we have deliberated on the untapped therapeutical possibilities and novel findings about this functional food, its biochemical composition, extraction methods, nutritional profiling, oil stability, and nutraceutical and pharmaceutical applications for its health benefits and ability to counter various diseases.
The clinical utility of cfRNA for disease detection and surveillance: A proof of concept study in non‐small cell lung cancer
Authors: Metzenmacher Martin , Hegedüs Balazs , Forster Jan , Schramm Alexander , Horn Peter A. , Klein Christoph A. , Bielefeld Nicola , Ploenes Till , Aigner Clemens , Siveke Jens T. , Schuler Martin , Lueong Smiths S. 
Published: June 2022

AbstractBackgroundCT scans are used in routine clinical practice for the diagnosis and treatment surveillance of non‐small cell lung cancer (NSCLC). However, more sensitive methods are desirable. Liquid biopsy analyses of RNA and DNA can offer more sensitive diagnostic approaches. Cell‐free RNA (cfRNA) has been described in several malignancies, but its clinical utility has not previously been explored.MethodsWe evaluated the clinical utility of cfRNA for early detection and surveillance of tumor disease in a proof‐of‐concept study. Using real‐time‐droplet digital polymerase chain reaction we characterized a candidate transcript (MORF4L2) in plasma samples from 41 advanced stage, 38 early stage NSCLC and 39 healthy samples. We compared its diagnostic performance with tumor markers and evaluated its utility for disease monitoring.ResultsMORF4L2 cfRNA was more abundant in patients than in healthy donors (p < 0.0001). Using the Youden index approach (cutoff value of 537 copies/ml was established) with a sensitivity of 0.73 (95% CI: 0.61–0.82) and a specificity of 0.87 (95% CI: 0.73–0.96). Positive and negative predictive values of 0.92 (95% CI: 0.83–0.95) and 0.59 (95% CI: 0.47–0.83) were achieved. Combination of cfRNA and Cyfra21‐1 improved its predictive value from 89.5% to 94.7%. Low baseline MORF4L2 levels were associated with better overall survival (HR:0.25, 95% CI: 0.09–0.7, p = 0.009) and progression‐free survival for patients treated with tyrosine kinase inhibitors (p = 0.011) and chemotherapy (p = 0.019). MORF4L2 profile between baseline and follow‐up mirrored radiological response and tumor dynamics better than tumor markers. cfRNA transcripts allowed monitoring tumor dynamics in patients without tumor‐reported genetic alterations.ConclusionOur data support clinical utility of cfRNA for detection and surveillance of NSCLC. Further studies with larger cohorts are required.