bluuebunny/crossref_metadata_2025_split huggingface dataset:
Region-based evidential deep learning to quantify uncertainty and improve robustness of brain tumor segmentation
Authors: Li Hao , Nan Yang , Del Ser Javier , Yang Guang 
Published: November 2022

AbstractDespite recent advances in the accuracy of brain tumor segmentation, the results still suffer from low reliability and robustness. Uncertainty estimation is an efficient solution to this problem, as it provides a measure of confidence in the segmentation results. The current uncertainty estimation methods based on quantile regression, Bayesian neural network, ensemble, and Monte Carlo dropout are limited by their high computational cost and inconsistency. In order to overcome these challenges, Evidential Deep Learning (EDL) was developed in recent work but primarily for natural image classification and showed inferior segmentation results. In this paper, we proposed a region-based EDL segmentation framework that can generate reliable uncertainty maps and accurate segmentation results, which is robust to noise and image corruption. We used the Theory of Evidence to interpret the output of a neural network as evidence values gathered from input features. Following Subjective Logic, evidence was parameterized as a Dirichlet distribution, and predicted probabilities were treated as subjective opinions. To evaluate the performance of our model on segmentation and uncertainty estimation, we conducted quantitative and qualitative experiments on the BraTS 2020 dataset. The results demonstrated the top performance of the proposed method in quantifying segmentation uncertainty and robustly segmenting tumors. Furthermore, our proposed new framework maintained the advantages of low computational cost and easy implementation and showed the potential for clinical application.
Mid-term efficacy and safety of Escherichia coli-derived rhBMP-2/hydroxyapatite carrier in lumbar posterolateral fusion: a randomized, multicenter study
Authors: Cho Minjoon , You KI-Han , Yeom Jin Sup , Kim Hyoungmin , Lee Kwang Bok , Cho Jae Hwan , Yang Jae Jun , Lee Jae Hyup 
Published: November 2022

Abstract
Purpose
This study aimed to evaluate the mid-term efficacy and safety of Escherichia coli-derived bone morphogenetic protein-2 (E.BMP-2)/hydroxyapatite (HA) in lumbar posterolateral fusion (PLF).

Methods
This multicenter, evaluator-blinded, observational study utilized prospectively collected clinical data. We enrolled 74 patients who underwent lumbar PLF and had previously participated in the BA06-CP01 clinical study, which compared the short-term outcomes of E.BMP-2 with an auto-iliac bone graft (AIBG). Radiographs and CT scans were analyzed to evaluate fusion grade at 12, 24, and 36 months. Visual analog scale (VAS), Oswestry disability index (ODI), and Short Form-36 (SF-36) scores were measured preoperatively and at 36 months after surgery. All adverse events in this study were assessed for its relationship with E.BMP-2.

Results
The fusion grade of the E.BMP-2 group (4.91 ± 0.41) was superior to that of the AIBG group (4.25 ± 1.26) in CT scans at 36 months after surgery (p = 0.007). Non-union cases were 4.3% in the E.BMP-2 and 16.7% in the AIBG. Both groups showed improvement in pain VAS, ODI, and SF-36 scores when compared to the baseline values, and there were no statistically significant differences between the two groups. No treatment-related serious adverse reactions were observed in either group. No neoplasm-related adverse events occurred in the E.BMP-2 group.

Conclusions
The fusion quality of E.BMP-2/HA was superior to that of AIBG. E.BMP-2/HA showed comparable mid-term outcomes to that of AIBG in terms of efficacy and safety in one-level lumbar PLF surgery.
Smart sharks: a review of chondrichthyan cognition
Authors: Brown Culum , Schluessel Vera 
Published: November 2022

Abstract450 million years of evolution have given chondrichthyans (sharks, rays and allies) ample time to adapt perfectly to their respective everyday life challenges and cognitive abilities have played an important part in that process. The diversity of niches that sharks and rays occupy corresponds to matching diversity in brains and behaviour, but we have only scratched the surface in terms of investigating cognition in this important group of animals. The handful of species that have been cognitively assessed in some detail over the last decade have provided enough data to safely conclude that sharks and rays are cognitively on par with most other vertebrates, including mammals and birds. Experiments in the lab as well as in the wild pose their own unique challenges, mainly due to the handling and maintenance of these animals as well as controlling environmental conditions and elimination of confounding factors. Nonetheless, significant advancements have been obtained in the fields of spatial and social cognition, discrimination learning, memory retention as well as several others. Most studies have focused on behaviour and the underlying neural substrates involved in cognitive information processing are still largely unknown. Our understanding of shark cognition has multiple practical benefits for welfare and conservation management but there are obvious gaps in our knowledge. Like most marine animals, sharks and rays face multiple threats. The effects of climate change, pollution and resulting ecosystem changes on the cognitive abilities of sharks and stingrays remain poorly investigated and we can only speculate what the likely impacts might be based on research on bony fishes. Lastly, sharks still suffer from their bad reputation as mindless killers and are heavily targeted by commercial fishing operations for their fins. This public relations issue clouds people’s expectations of shark intelligence and is a serious impediment to their conservation. In the light of the fascinating results presented here, it seems obvious that the general perception of sharks and rays as well as their status as sentient, cognitive animals, needs to be urgently revisited.
RNAseq analysis of olfactory neuroepithelium cytological samples in individuals with Down syndrome compared to euploid controls: a pilot study
Authors: Brozzetti Lorenzo , Scambi Ilaria , Bertoldi Loris , Zanini Alice , Malacrida Giorgio , Sacchetto Luca , Baldassa Lucia , Benvenuto Giuseppe , Mariotti Raffaella , Zanusso Gianluigi , Cecchini Maria Paola 
Published: November 2022

AbstractDown syndrome is a common genetic disorder caused by partial or complete triplication of chromosome 21. This syndrome shows an overall and progressive impairment of olfactory function, detected early in adulthood. The olfactory neuronal cells are located in the nasal olfactory mucosa and represent the first sensory neurons of the olfactory pathway. Herein, we applied the olfactory swabbing procedure to allow a gentle collection of olfactory epithelial cells in seven individuals with Down syndrome and in ten euploid controls. The aim of this research was to investigate the peripheral gene expression pattern in olfactory epithelial cells through RNAseq analysis. Validated tests (Sniffin’ Sticks Extended test) were used to assess olfactory function. Olfactory scores were correlated with RNAseq results and cognitive scores (Vineland II and Leiter scales). All Down syndrome individuals showed both olfactory deficit and intellectual disability. Down syndrome individuals and euploid controls exhibited clear expression differences in genes located in and outside the chromosome 21. In addition, a significant correlation was found between olfactory test scores and gene expression, while a non-significant correlation emerged between olfactory and cognitive scores. This first preliminary step gives new insights into the Down syndrome olfactory system research, starting from the olfactory neuroepithelium, the first cellular step on the olfactory way.Graphical Abstract
FIRES—Pathophysiology, therapeutical approach, and outcome
Authors: Reppucci Diana , Datta Alexandre N. 
Published: November 2022

AbstractBackgroundThe acronym FIRES stands for febrile infection-related epileptic syndrome, which is a rare epileptic syndrome in the pediatric population. The initial presentation of FIRES is similar to febrile seizures (FS). Both start after a febrile episode; however, in FIRES the epileptic seizure evolves into a super refractory status epilepticus within days despite appropriate treatment. FIRES needs to be diagnosed early and treated by a multidisciplinary team to control the status epilepticus (SE) as fast as possible. Limiting the duration of the SE is paramount for the prevention of catastrophic sequelae such as severe neurologic disabilities or even death.Objective/ConclusionWe describe possible pathophysiological mechanisms and summarize important clinical features of FIRES. The aim of this review is to raise awareness, foster early recognition and improve neurologic long-term outcomes. Moreover, we propose a diagnostic approach and list therapeutic options providing an algorithm.
Traditional oases in Northern Africa as multifunctional agroforestry systems: a systematic literature review of the provided Ecosystem Services and of the main vulnerabilities
Authors: Santoro Antonio 
Published: November 2022

AbstractTraditional oases represent unique forms of adaptation to extreme environmental conditions, developed through the centuries by local farmers to support their livelihood, combining different crops (date palms, fruit trees, vegetables and fodder) with livestock breeding. Despite their social, economic and cultural importance, these agroforestry systems are currently facing multiple socio-environmental threats. The aim of the paper is to investigate the variety of Ecosystem Services (ES) and the main threats related to traditional oases in Northern Africa through a systematic literature review. The search returned 257 relevant papers published from 2005 to March 2022, mostly focusing on Tunisian oases (37%), followed by Algerian (23%), Moroccan (19%), Egyptian (17%), and Libyan (4%). Provisioning Services, in particular Genetic diversity, agrobiodiversity and biodiversity, are the most cited ES (36% of the papers) followed by Cultural Services, mainly represented by Traditional knowledge systems, cultural heritage and sense of place (17%), while Regulating Services are less considered. Results highlighted that water related issues (desertification, drought, salinization or overexploitation) represent the main threat, followed by decrease of agrobiodiversity, primarily due to the spread of monocultures of commercial date varieties, and by social transformations (depopulation, traditional knowledge and cultural heritage loss). The literature review proved that traditional oases are still crucial for the livelihood of local communities since they still provide many ES. Local experiences related to sustainable development and tourism, or innovative solutions to valorize local products and byproducts, could be important for replication in other traditional oases to contribute to the wellbeing of local communities and to the preservation of these agroecosystems.
Peer Workers in Co-production and Co-creation in Mental Health and Substance Use Services: A Scoping Review
Authors: Åkerblom Kristina Bakke , Ness Ottar 
Published: November 2022

AbstractPeople with lived experience of mental health challenges are extensively employed as peer workers within mental health and substance use services worldwide. Research shows that peer workers benefit individuals using such services and can have essential roles in developing recovery-oriented services. However, understanding how peer workers’ contributions, by their role, functions, and input can be better used remains a critical challenge. Research on public sector innovation has focused on relevant actors collaborating to tackle complex demands. Co-production and co-creation are concepts used to describe this collaboration. Co-production refers to the collaboration between providers and users at the point of service delivery, whereas co-creation refers to collaboration starting in the early service cycle phases (e.g., in commissioning or design), including solution implementation. We overviewed research literature describing peer workers’ involvement in mental health and substance use services. The research question is as follows: How are peer workers involved in co-production and co-creation in mental health and substance use services, and what are the described outcomes? A literature search was performed in 10 different databases, and 13,178 articles were screened, of which 172 research articles describing peer workers’ roles or activities were included. The findings show that peer workers are involved in co-production and function as providers of pre-determined services or, most often, as providers of peer support. However, they are rarely engaged as partners in co-creation. We conclude that the identified peer worker roles have different potential to generate input and affect service delivery and development.
The gill epithelial cell lines RTgill-W1, from Rainbow trout and ASG-10, from Atlantic salmon, exert different toxicity profiles towards rotenone
Authors: Solhaug Anita , Gjessing Mona , Sandvik Morten , Eriksen Gunnar Sundstøl 
Published: November 2022

AbstractIn order to ensure the proper use and interpretation of results from laboratory test systems, it is important to know the characteristics of your test system. Here we compare mitochondria and the handling of reactive oxygen species (ROS) in two gill epithelial cell lines, the well-known RTgill-W1 cell line from Rainbow trout and the newly established ASG-10 cell line from Atlantic salmon. Rotenone was used to trigger ROS production. Rotenone reduced metabolic activity and induced cell death in both cell lines, with RTgill-W1 far more sensitive than ASG-10. In untreated cells, the mitochondria appear to be more fragmented in RTgill-W1 cells compared to ASG-10 cells. Furthermore, rotenone induced mitochondrial fragmentation, reduced mitochondria membrane potential (Δψm) and increased ROS generation in both cell lines. Glutathione (GSH) and catalase is important to maintain the cellular oxidative balance by eliminating hydrogen peroxide (H2O2). In response to rotenone, both GSH and catalase depletion were observed in the RTgill-W1 cells. In contrast, no changes were found in the GSH levels in ASG-10, while the catalase activity was increased. In summary, the two salmonid gill cell lines have different tolerance towards ROS, probably caused by differences in mitochondrial status as well as in GSH and catalase activities. This should be taken into consideration with the selection of experimental model and interpretation of results.
Graphical abstract
Determinants of higher education teachers’ intention to use technology-based exams
Authors: Fink Aron , Spoden Christian , Frey Andreas 
Published: November 2022

AbstractThe replacement of existing technology or the introduction of novel technology into the day-to-day routines of higher education institutions is not a trivial task. Currently, many higher education institutions are faced with the challenge of replacing existing procedures for administering written exams with e-exams. To guide this process, this paper proposes the novel technology-based exams acceptance model (TEAM) and empirically evaluates its model structure and usefulness from the perspective of higher education teachers. The model can be used to guide the transition from paper-based exams to e-exams and the implementation of innovative (e.g., adaptive) e-exam formats. The model includes perceived usefulness, computer self-efficacy, computer anxiety, prior experience, facilitating conditions, and subjective norm as predictors of the behavioral intention to use e-exams. To test the model empirically, the responses of 992 teachers at 63 German universities to a standardized online questionnaire were analyzed using structural equation modeling. The model fit was acceptable. With 77% (conventional e-exams) and 82% (adaptive e-exams), a large proportion of the variance of the intention to use these types of exams was explained. With TEAM, a highly predictive model for explaining the behavioral intention to use e-exams is now available. It offers a theoretical basis that can be used for the successful implementation of e-exams in higher education.
Statistical and clustering validation analysis of primary students' learning outcomes and self-awareness of information and technical online security problems at a post-pandemic time
Authors: Panskyi Taras , Korzeniewska Ewa 
Published: November 2022

Abstract
The authors decided to investigate the impact of the pandemic period and the resulting limitations in Polish primary school online security education. The first part of the study investigates the impact of the COVID-19 pandemic on students’ educational learning outcomes in information and Internet security. The study has been performed via a student-oriented survey of 20 questions. The statistical analysis confirms the significant difference before and after the pandemic in several questions at most. Nevertheless, this justifies the statement that pandemics had a positive impact on post-pandemic Internet-related security education. The second part of the study has been focused on students' perception and self-awareness of cyberspace problems. For this purpose, the authors used novel majority-based decision fusion clustering validation methods. The revealed results illustrate the positive tendency toward the students' self-awareness and self-confidence of online security problems and e-threats before, during and after the challenging pandemic period. Moreover, the presented validation methods show the appealing performance in educational data analysis, and therefore, the authors recommended these methods as a preprocessing step that helps to explore the intrinsic data structures or students' behaviors and as a postprocessing step to predict learning outcomes in different educational environments.
The “Great Lockdown” and cultural consumption in the UK
Authors: Bakhshi Hasan , Di Novo Salvatore , Fazio Giorgio 
Published: November 2022

AbstractIn this paper, we exploit a unique weekly longitudinal survey of adults in the UK purposefully collected to study consumption choices with respect to cultural content types during the first Covid-19 national lockdown (the “Great Lockdown”). We look for changes in the probability of consuming different cultural and creative types of content (Music, Movies, TV, Games, Books, Magazines and Audiobooks), as well as changes in the overall variety of consumption. We find that changes in consumption depend on the type of content. In particular, other things being equal, the likelihood of listening to Music and playing Games went up and the likelihood of reading Books went down. We find little statistically significant evidence of changes in the probability of consumption of the other types of content. We find that, while on average individuals increased the variety of their consumption, the statistical significance of this increase varied depending on the socio-demographic and economic characteristic of interest. In particular, we find evidence of an increase in the variety of consumption for those at the bottom of the distribution of socio-economic status, which speaks to the importance of access to culture and creativity during lockdown for this specific social class.
Change Patterns During Family-Based Treatment for Pediatric Obsessive Compulsive Disorder
Authors: McGrath Chloe A. , Abbott Maree J. , Mantz Sharlene C. , O’Brien Margot , Costa Daniel S. J. , Waters Felicity 
Published: November 2022

AbstractCognitive behavior therapy (CBT) for young people with obsessive compulsive disorder (OCD) has recently been enhanced to target family environment factors. However, the process of change for OCD symptoms and family factors during treatment is not well understood. Uniquely, we explored patterns of change for OCD symptoms and a range of family variables throughout Baseline, Early, Mid, and Late treatment phases of family-based CBT (FCBT) for 15 young people with OCD using multiple informants. We predicted a linear reduction in OCD symptom severity and family accommodation (FA) across treatment phases, however the investigation into other family factor change patterns was exploratory. OCD symptom severity, FA, parental distress tolerance (DT), and conflict all showed significant linear change patterns across treatment phases according to multiple informants. In addition, the largest proportion of change for these variables typically occurred during the first third of treatment, highlighting the importance of identifying participants with and without early gains in future research. Blame also showed a significant linear change pattern, although with small reductions between treatment phases. Preliminary bivariate analyses sought to better understand whether family factor change predicted subsequent OCD severity change or vice versa. Similar patterns emerged across informants, including identification of OCD severity as a significant predictor of change for Blame at subsequent treatment phases. Analyses also showed bi-directional effects for DT and OCD symptoms across informants, where DT predicted OCD severity at subsequent treatment phases and vice versa. These outcomes support further research aimed at understanding the role of family factors in pediatric OCD symptom change.
Hart as an Inferentialist: The Methodological Pragmatist Insight in Hart’s Inaugural Lecture
Authors: Liu Ziyu 
Published: November 2022

AbstractJurisprudes today differ in their interpretations of H.L.A. Hart’s analysis of the semantics of internal legal statements. Drawing upon the philosophy of language and metaethics to reconstruct Hart’s view, they disagree as to whether Hart should be interpreted as an expressivist or quasi-expressivist. In this paper I propose a third reconstruction, under which Hart adopted an inferentialist analysis of the semantics of internal legal statements. In executing this reconstruction, I focus on Hart’s inaugural lecture, and utilize the theoretical apparatus of Robert Brandom, a leading advocate of inferential role semantics, to bring Hart’s methodological pragmatist—and more specifically inferentialist—insight in that lecture to the fore.