bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex differences in epigenetic age in Mediterranean high longevity regions
Authors: Engelbrecht Hannah-Ruth , Merrill Sarah M. , Gladish Nicole , MacIsaac Julie L. , Lin David T. S. , Ecker Simone , Chrysohoou Christina A. , Pes Giovanni M. , Kobor Michael S. , Rehkopf David H. 
Published: November 2022

Sex differences in aging manifest in disparities in disease prevalence, physical health, and lifespan, where women tend to have greater longevity relative to men. However, in the Mediterranean Blue Zones of Sardinia (Italy) and Ikaria (Greece) are regions of centenarian abundance, male-female centenarian ratios are approximately one, diverging from the typical trend and making these useful regions in which to study sex differences of the oldest old. Additionally, these regions can be investigated as examples of healthy aging relative to other populations. DNA methylation (DNAm)-based predictors have been developed to assess various health biomarkers, including biological age, Pace of Aging, serum interleukin-6 (IL-6), and telomere length. Epigenetic clocks are biological age predictors whose deviation from chronological age has been indicative of relative health differences between individuals, making these useful tools for interrogating these differences in aging. We assessed sex differences between the Horvath, Hannum, GrimAge, PhenoAge, Skin and Blood, and Pace of Aging predictors from individuals in two Mediterranean Blue Zones and found that men displayed positive epigenetic age acceleration (EAA) compared to women according to all clocks, with significantly greater rates according to GrimAge (β = 3.55; p = 1.22 × 10−12), Horvath (β = 1.07; p = 0.00378) and the Pace of Aging (β = 0.0344; p = 1.77 × 10−08). Other DNAm-based biomarkers findings indicated that men had lower DNAm-predicted serum IL-6 scores (β = -0.00301, p = 2.84 × 10−12), while women displayed higher DNAm-predicted proportions of regulatory T cells than men from the Blue Zone (p = 0.0150, 95% Confidence Interval [0.00131, 0.0117], Cohen’s d = 0.517). All clocks showed better correlations with chronological age in women from the Blue Zones than men, but all clocks showed large mean absolute errors (MAE &gt;30 years) in both sexes, except for PhenoAge (MAE &lt;5 years). Thus, despite their equal survival to older ages in these Mediterranean Blue Zones, men in these regions remain biologically older by most measured DNAm-derived metrics than women, with the exception of the IL-6 score and proportion of regulatory T cells.
Intravenous thrombolysis in ischemic stroke patients based on non-contrast CT in the extended time-window
Authors: Emde Julia , Baumgart Romy , Langguth Niklas , Juenemann Martin , Gerner Stefan T. 
Published: November 2022

Purpose of reviewRecent trials provided evidence for safety and efficacy of intravenous thrombolytic therapy (IVT) in ischemic stroke patients beyond the 4.5 h time-window if ischemic penumbra is present in multimodal imaging. However, advanced imaging by either Magnet Resonance Imaging (MRI) or Computed Tomography Perfusion (CTP) is not available 24/7 at most stroke-centers. Therefore, the current review addresses the use of non-contrast CT (NCCT) to identify ischemic stroke patients suitable for IVT in the unknown or extended time-window in terms of efficacy and safety.Recent findingsThe current data on NCCT based IVT strategies in ischemic stroke patients presenting in the unknown or late time-window are relatively scarce and mainly provided by small retrospective samples. One larger registry (TRUST-CT) underlines the safety and efficacy of IVT without advanced imaging with more IVT-patients reaching an excellent outcome compared to the non-IVT treated control group. Current meta-analysis provides evidence that the rate of symptomatic intracerebral hemorrhage (sICH) is similar in the wake-up and unknown onset time-window compared to the 4.5 h time-window if patients are selected by NCCT. Results of the upcoming TWIST-trial investigating Tenecteplase (TNK) for NCCT-based IVT revealed no signals regarding an increased rate of sICH, however there was no benefit regarding functional outcomes.SummarySo far, it is not well-established whether advanced imaging is indispensable and NCCT could be sufficient to identify stroke patients in the extended window who would benefit from IVT-treatment. However, current data suggests the safety of NCCT-based IVT in the extended time-window. Therefore, unavailable advanced neuroimaging should not cause delay, or even exclusion of patients from IVT and other recanalizing therapies per se.
Standardized evaluation of satisfaction within urology residents during clinical training: Implementation of a new urological residency rotation program at the university hospital Frankfurt
Authors: Siech Carolin , García Cristina Cano , Leyh Herbert , Schmid Hans-Peter , Engl Tobias A , Karakiewicz Pierre I , Becker Andreas , Chun Felix K-H , Banek Séverine , Kluth Luis A 
Published: November 2022

BackgroundStructured curricula are demanded to improve training programs of future urologists. This study aimed to evaluate the acceptance of the newly implemented residency rotation program at the University Hospital Frankfurt. Primary endpoint was resident's satisfaction with the current residency rotation program. Secondary endpoint was the fulfilment of the objectives and expectations by residents.MethodsA standardized 15-item, online-based survey was sent to every urologic resident of the University Hospital Frankfurt, completing their rotation between August 2020 and August 2022. In addition to baseline characteristics, training and working conditions were assessed. Descriptive statistics were applied.ResultsIn total 15 rotations of the Residency Rotation Program at the University Hospital Frankfurt were evaluated, including urologic practice (5/15), Intermediate Care Unit (4/15), urooncology (4/15) and clinical exchange to St. Gallen (2/15). Overall, the majority were very (67%) or rather satisfied (2%) with their rotation. Of the pre-rotation defined objectives, 71% were fulfilled, 18% partially fulfilled and 8% not fulfilled. With respect to the expectations, 67% were fulfilled, 19% partly fulfilled and 4% were not fulfilled. All residents would recommend their respective rotations.ConclusionOur results demonstrate that the residency rotation program at the University Hospital Frankfurt enjoys a high level of acceptance as well as a positive impact on urologic training. Satisfaction with the completed rotation was convincing, most of the expectations and objectives for the respective rotation could be fulfilled. These results help to ensure the quality of urologic curricula and to improve the structure of training programs for future urologists.
Metabolic and hormonal changes after laparoscopic sleeve gastrectomy in pediatric population: An observational study
Authors: Alghamdi Hashim , Asiri Ashwag , Alzahrani Faris , Alamri Zainab , AbdelQadir Yossef Hassan , Shah Jaffer 
Published: November 2022

IntroductionDespite the growing popularity of laparoscopic sleeve gastrectomy (SG) for managing severe obesity in children, adolescents, and adults, there is a paucity of studies reporting the effects of SG on metabolic and hormonal outcomes in pediatric populations.MethodologyIn this single-centre, retrospective study, we assessed nutritional biomarkers (hemoglobin, ferritin, iron profile, Vitamin B12, Vitamin D, and calcium), glucose homeostasis indicators (C-peptide, HbA1C, and random blood glucose), blood lipids (triglycerides and cholesterol components), hormones involved in the hypothalamic-pituitary-adrenal axis (cortisol and adrenocorticotropic hormone), and thyroid hormones (T3, T4, thyroid-stimulating hormone, and parathyroid hormone) preoperatively and 12-month after SG in children aged 5–15 years.ResultsThis study included 64 adolescents (mean age = 11.2 ± 2.3 years) who underwent laparoscopic SG. Significant reduction in circulatory C-peptide (−62.1%; p = 0.005), HbA1C (−10.9%; p = 0.001), random blood glucose (−15.4%; p = 0.036), and triglycerides (−39.4%; p = 0.003) were observed postoperatively at 12 months compared to baseline. Although we did not observe any changes in cortisol levels, adrenocorticotropic hormone levels declined significantly by −40.9% postoperatively (p = 0.033). However, cholesterol components, thyroid hormones, and nutritional biomarkers remained unchanged from baseline.ConclusionsConsistent with prior literature, our study demonstrates improvement or resolution of diabetes and hypertriglyceridemia in the year following SG. However, given that blood cholesterol components, nutritional biomarkers, and thyroid profiles remained unchanged warrants long-term monitoring of nutritional, metabolic, and endocrine factors in adolescents undergoing laparoscopic SG. To the best of our knowledge, this is the first study reporting the effects of SG on thyroid and hypothalamic-pituitary-adrenal axis hormones in pediatric populations.
Informal Support Networks of Tanzanians With Chronic Diseases: Predictors of Support Provision and Treatment Adherence
Authors: Hooley Brady , Mtenga Sally , Tediosi Fabrizio 
Published: November 2022

Objectives: To examine the role of NCD patients’ social ties as informal caregivers and whether receiving their support is associated with engagement in care.Methods: NCD outpatients (N2 = 100) in rural Tanzania completed a cross-sectional questionnaire to characterize the support role of their social ties (N1 = 304). Bivariate analyses explored predictors of social support and whether social support is associated with engagement in care.Results: This study found that 87% of participants had health insurance, yet 25% received financial support for financing healthcare. Patient gender, age and marital status were found to be important predictors of social support, with NCD-related disability and disease severity being predictive to a lesser degree. Monthly receipt of both material and non-material support were associated with increased odds of adherence to prescribed medications.Conclusion: These findings indicate that patients’ social ties play an important role in filling the gaps in formal social health protection and incur substantial costs by doing so. The instrumental role of even non-material social support in promoting engagement in care deserves greater attention when developing policies for improving this population’s engagement in care.
MANAR DE HAMA
Authors: Campello Priscila Campolina de Sá , Teixeira Frederico Dias Rosa Alves , Santos Nicolas Walter dos , Matos e Silva Julia Magalhães , Faleiro Paula Bernardes 
Published: November 2022

Tradução do conto Manar of Hama, da autora árabe-estadunidense Mohja Kahf.
ESTILÍSTICA DO LEITOR COROADO: SUBVERSÃO E CARNAVALIZAÇÃO NA CONSTRUÇÃO DO GÊNERO DISCURSIVO FANFICTION
Authors: Silva Juan , Andrade Jandara Assis de Oliveira , Dos Santos Gabrielle Leite , Casado Alves Maria da Penha 
Published: November 2022

Este trabalho analisa a fanfic como prática literária de experimentação em que os valores, questões e identidades dos autores são refletidas e refratadas para suas narrativas. Para tanto, compreende a fanfiction como produção escriturística realizada por sujeitos fãs, em fandoms, motivada pela relação emotivo-volitiva de afetividade desses sujeitos com um texto matriz. Para alcançar nossos objetivos, fazemos uso dos postulados advindos de Bakhtin (2015a; 2015b; 2015c), sobretudo referente à discussão de signo, ideologia, gêneros discursivos, carnavalização, coroação-destronamento e reelaboração. Na tentativa de aprofundar o debate, discussões acerca de cultura da convergência e da antropologia especulativa apontadas por Jenkins (2009) e Nodari (2015) juntam-se ao arcabouço teórico. Por fim, a pesquisa demonstrou elementos estilísticos que caracterizam e diferenciam a fanfic de outros gêneros romanescos e como sua prática é vetor de experimentação identitária para aqueles que a produzem.
REFERÊNCIAS
A. MHADHBI. Estudo da ONU revela que mundo tem abismo digital de gênero. ONU News: Perspectiva Global Reportagens Humanas. nov. 2019. Disponível em: https://news.un.org/pt/story/2019/11/1693711. Acesso em: 12 jul. 2021.
BAKHTIN, Mikhail M. Os gêneros do discurso. Tradução Paulo Bezerra. São Paulo: 34, 2016.
BAKHTIN, Mikhail M. Cultura popular na idade média e no renascimento: o contexto de François Rabelais. São Paulo: Hucitec, 2015a.
BAKHTIN, Mikhail M. Problemas da poética de Dostoievski. Tradução Paulo Bezerra. 5. ed. Rio de Janeiro: Forense Universitária, 2015b.
BAKHTIN, Mikhail M. Teoria do romance I: a estilística. Tradução Paulo Bezerra. São Paulo: 34, 2015c.
BAKHTIN, Mikhail M. Estética da criação verbal. Tradução de Paulo Bezerra. 4. ed. São Paulo: Martins Fontes, 2003.
BENJAMIM, W. A obra de arte na era de sua reprodutibilidade técnica. In: ______. Magia e técnica, arte e política: ensaios sobre literatura e história da cultura. Obras escolhidas. São Paulo: Brasiliense, 1987. v. 1.
JAMISON, Anne. Fic: porque a fanfiction está dominando o mundo. Tradução Marcelo Barbão. Rio de Janeiro: Anfiteatro, 2017.
JENKINS, Henry. Invasores do texto: fãs e cultura participativa. Tradução Érico Assis. Nova Iguaçu: Marsupial, 2015.
JENKINS, H. Cultura da convergência. Tradução Susana L. de Alexandria. 2. ed. São Paulo: Aleph, 2009.
KUNDERA, Milan. A arte do romance. Tradução Teresa Bulhões Carvalho da Fonseca. São Paulo: Companhia das Letras, 2009.
MEYER, Stephenie. Crepúsculo. Tradução Ryta Vinagre. Rio de Janeiro: Intrínseca, 2009.
NA MANCHA, UM SUICIDA: SOBRE A MORTE DE RORSCHACH EM WATCHMEN, DE ALAN MOORE E DAVE GIBBONS
Authors: Gulicz Igor , André Willian 
Published: November 2022

Este artigo propõe uma análise do graphic novel Watchmen (1986-1987), escrito por Alan Moore e ilustrado por Dave Gibbons. O foco da análise é o personagem Rorschach, cuja morte no desfecho da narrativa é interpretada aqui como sendo um suicídio, e não um sacrifício. Para sustentar tal hipótese, propõe-se principalmente um diálogo com o ensaio O mito de Sísifo (1942), de Albert Camus.
REFERÊNCIAS
ALVAREZ, Alfred. O deus selvagem: um estudo do suicídio. Trad. Sonia Moreira. São Paulo: Companhia das Letras, 1999.
CAMUS, Albert. O mito de Sísifo. Trad. Ari Roitman e Paulina Wacht. 6 ed. São Paulo/Rio de Janeiro: Record, 2008.
HELD, J. Podemos Conduzir este Mundo sem Leme? Kant, Rorschach, Retributivismo e Honra. In: WHITE, Mark D. (Org.). Watchmen e a Filosofia: um teste de Rorschach. Trad. Uiran Gebara da Silva. São Paulo: Madras, 2009. p. 29-39
MOORE, Alan; GIBBONS, Dave. Watchmen – Edição Definitiva. Trad. Jotapê Martins e Helcio de Carvalho. Barueri: Panini, 2011.
SANTOS, R. O caos dos quadrinhos modernos. In: Comunicação & Educação, n. 2, 30 abr. Moderna: São Paulo, 1995, p. 53-58.
SOLOMON, Andrew. O Demônio do Meio-Dia: uma anatomia da depressão. Trad. Myriam Campello. São Paulo: Companhia das Letras, 2014.
TEIXEIRA, N; CORREA, W. Watchmen e o discurso distópico do “bem maior”. In: Revista Fênix: 2009, vol. 6. Disponível em: <https://www.revistafenix.pro.br/revistafenix/article/view/141/131> Acesso em: 28 de agosto de 2021.
PRIMITIVISMO POÉTICO EM OSWALD DE ANDRADE: VANGUARDA E INTERTEXTUALIDADE
Authors: Pires Anderson 
Published: November 2022

Pau Brasil é o primeiro livro de poemas de Oswald de Andrade, publicado em Paris em 1925, pela editora Au Sans Pareil. Mais do que um livro de estreia, um livro seminal para se compreender o aproveitamento estético do coloquial no modernismo brasileiro.
REFERÊNCIAS
AMARAL, Aracy A. Tarsila – sua obra e seu tempo. São Paulo: Ed.34/Edusp, 2003.
ANDRADE, Oswald. Pau-Brasil. São Paulo: Globo, 1990.
BAUDELAIRE, Charles. Sobre a modernidade. São Paulo: Paz e Terra, 1996.
BELLUZZO, Ana Maria. Modernidade: vanguardas artísticas na América Latina. São Paulo: Ed. UNESP, 1990.
BOSI, Alfredo. Dialética da colonização. São Paulo: Cia. das Letras, 2008.
DA SILVA, Anderson Pires. Mário e Oswald – uma história privada do modernismo. Rio de Janeiro: 7Letras/Faperj, 2009.
FONSECA, Maria Augusta. Por que ler Oswald de Andrade. São Paulo: Globo, 2008.
HUTCHEON, Linda. Poética do pós-modernismo. Rio de Janeiro: Imago, 1991.
LIMA, Luiz Costa. Oswald de Andrade – a utopia antropofágica, uma utopia sem história. In:______ TELES, Gilberto Mendonça et. al. Oswald plural. Rio de Janeiro: UERJ, 1995.
HAWKING, Stephen. Uma breve história do tempo. Rio de Janeiro: Intrínseca, 2015.
HOLLANDA, Heloísa Buarque (Org.). 26 poetas hoje. Rio de Janeiro: Aeroplano, 2007.
JAUSS, Hans Robert. A história da literatura como provocação à teoria literária. São Paulo: Ática, 1994.
MENDES, Murilo. Poesia completa. Rio de Janeiro: Nova Fronteira, 2003.
MINK, Janis. Duchamp – a arte como contra-arte. Lisboa: Taschen, 2000.
RASM – Revista Anual do Salão de Maio de 1939. ed. fac-similar. São Paulo: Editora Gráfica, 1984.
SANTIAGO, Silviano. Ora direis puxar conversa. Belo Horizonte: EdUFMG, 2006.
Première observations sur le comportement de chasse et de capture chez les vipères et les couleuvres
Authors: Naulleau G. 
Published: November 2022

Chez Vipera, toute proie (vivante ou morte) agitée devant le Serpent est observée et suivie à vue ; ce n’est que très près que les sens chimiques entrent en jeu grâce aux mouvements de langue. C’est de ces derniers sens que dépend l’acceptation ou le refus définitif de la proie. La signification des proies chez les Vipères ne dépend que de leur motivation interne.
Les proies ne laissent de pistes odorantes que par contact avec le sol ou différents objets naturels (pierres, souches, végétation, etc...). Lorsque les traces laissées par les proies s’entrecroisent, les Vipères ne peuvent pas discerner le sens des pistes odorantes et elles ne retrouvent leurs proies qu’après de nombreux essais et erreurs.
La vue intervient d’abord dans la poursuite des proies vivantes non encore mordues et joue le rôle principal ; après morsure, le rôle des sens chimiques devient prédominant.
La poursuite à l’aide de la langue semble liée à l’état de la proie. Une proie morte (envenimée ou non) peut être uniquement suivie à l’aide de la langue par sa trace, tandis qu’une proie vivante (bien que plus attractive) ne peut être suivie par sa trace qu’après morsure.
Chez les Vipères, deux phénomènes bien distincts entrent en jeu avant la déglutition : 1° une reconnaissance olfactive, gustative et tactile à l’aide de la langue dont dépend l’acceptation définitive de la proie, et 2° une reconnaissance visuelle de la tête de la proie, point de départ de la déglutition.
Dans les conditions naturelles, c’est-à-dire lorsque les proies sont vivantes, le comportement de chasse des Vipères dépend de deux phénomènes bien distincts : 1° avant la morsure, une poursuite où les mouvements de langue sont rares ou nuis et dans laquelle la vue joue le plus grand rôle. Cette poursuite est rapide et la tête de la Vipère, portée haute au-dessus du sol, reste toujours très près de la proie. Les deux parcours, celui de la Souris et de la Vipère sont plus ou moins superposables. Il faut rappeler que la Vipère voit mieux les mouvements de la proie que la proie elle-même ; 2° après une première morsure le rôle de la langue devient prépondérant. La poursuite est lente et s’effectue avec de nombreux mouvements intermittents de la langue. Le trajet parcouru par la Vipère est toujours sinueux, mais s’écarte peu de part et d’autre de la trace laissée par la Souris.
Chez Natrix natrix et Natrix viperinus la prédation peut être divisée en deux parties : 1° un comportement de chasse sur le sol où la vue joue le plus grand rôle, sinon l’unique, et 2° un comportement de chasse dans l’eau où la vue et la langue interviennent simultanément.
Un leurre en caoutchouc mousse figurant une Rainette (Hyla arborea) agité sur l’eau devant Natrix viperinus détermine le même comportement qu’une proie naturelle chez cette Couleuvre.
Méthodes d’étude des zoocoenoses prairiales
Authors: Ricou Germaine 
Published: November 2022

Une technique réunissant l’emploi du cylindre et du fauchoir a été mise au point pour l’étude quantitative de la zoocoenose des prairies permanentes pâturées.
Les problèmes posés par l’échantillonnage des milieux sont complexes ; ils sont envisagés sous le double aspect de la vérification de la technique et de l’interprétation des chiffres obtenus.
Ils concernent le nombre des prélèvements à exécuter et la surface qu’ils doivent couvrir pour fournir une estimation valable du peuplement. Une discussion sur la valeur comparée des captures du cylindre et du fauchoir fixe les limites d’utilisation de chacun ; elle a trait, notamment, au problème de la stratification dans la couche herbacée.
La distribution des fréquences suit d’assez loin les modèles mathématiques, même lorsqu’il s’agit d’espèces abondantes. Dans l’ensemble, la tendance au rassemblement par taches est évidente.
Il est possible d’estimer quantitativement le niveau d’abondance de certaines espèces ; pour d’autres, on peut définir les limites à l’intérieur desquelles se situent les niveaux des populations.
Premier aperçu sur les sols et leur valeur agronomique
Authors: Delmas J. 
Published: November 2022

Two main categories of soils occur in the Lamto savannas, tropical ferrugineous soils and black clays.
The ferrugineous soils are the most widespread, covering all the «high ground» and the valley slopes. They are very poor in Calcium, Potassium, Phosphorus, organic matter and Nitrogen — and their agronomic value is therefore very low.
The black clays occur only locally, where amphibolites almost reach ground level ; they are very hydromorphic, rich in Calcium, Magnesium and organic matter, but poor in Potassium and Phosphorus.
After the dry season bush fires (table II) a temporary increase in the amount of Potassium, Magnesium and Phosporus of the top soil layer has been observed. This may account for the rapid growth of the new grass.
Données préliminaires sur le cycle annuel de la végétation herbacée
Authors: Roland Jean-Claude 
Published: November 2022

170 species of plants have been found in the Lamto savannas, 129 of which belong to the herb layer. The most abundant families are the Gramineae (27.9 % of the species), the Cyperaceae (17.8 %) and the Leguminosae (16.2 %). The percentage of the various lifeforms is as follows : Therophytes, 43.5 % ; Hemicryptophytes, 36.1 % ; Geophvtes, 11.1 % and Chamaephytes, 8.2 %. Various associations are described, but two main vegetation types are recognized : the Andropogon savanna on well drained tropical ferrugineous soils and the Loudetia simplex prairie on black clays.
The yearly cycle of the grass biomass is described in burnt and unburnt savannas (figures 7 and 8) : the primary production is estimated to be between 25 and 30 tons of plant tissues (fresh weight) per hectare per year — out of which 76 % are imputable to the grass layer, 15 % to the bush layer and 9 % to the tree layer.
Données préliminaires sur le peuplement en fourmis terricoles
Authors: Lévieux Jean 
Published: November 2022

The ant populations of the Lamto savanna have been studied during the rainy season of 1965. The distribution and number of ant colonies is mainly influenced by the soil conditions. In tropical ferrugineous soils, the dominant species is Campanotas acvapimensis, while Pheidole sp. is more abundant in the damp and sandy areas. In valleys a number of forest species (Odontomachus troglodytes, Psalidomyrmex sp.) are found, extending from the gallery forest. The black clays are inhabited by the same species as the tropical ferrugineous soils, but their relative abundance is different.
On the average, about 7000 ant colonies per hectare are found in the Lamto savanna. Table V gives the maximum and average colony sizes of 12 species. Colony size in small Ponerine ants is much smaller than in larger species.