bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Genomically and Clinically Annotated Patient-Derived Xenograft Resource for Preclinical Research in Non–Small Cell Lung Cancer
Authors: Woo Xing Yi , Srivastava Anuj , Mack Philip C. , Graber Joel H. , Sanderson Brian J. , Lloyd Michael W. , Chen Mandy , Domanskyi Sergii , Gandour-Edwards Regina , Tsai Rebekah A. , Keck James , Cheng Mingshan , Bundy Margaret , Jocoy Emily L. , Riess Jonathan W. , Holland William , Grubb Stephen C. , Peterson James G. , Stafford Grace A. , Paisie Carolyn , Neuhauser Steven B. , Karuturi R. Krishna Murthy , George Joshy , Simons Allen K. , Chavaree Margaret , Tepper Clifford G. , Goodwin Neal , Airhart Susan D. , Lara Primo N. , Openshaw Thomas H. , Liu Edison T. , Gandara David R. , Bult Carol J. 
Published: September 2022

AbstractPatient-derived xenograft (PDX) models are an effective preclinical in vivo platform for testing the efficacy of novel drugs and drug combinations for cancer therapeutics. Here we describe a repository of 79 genomically and clinically annotated lung cancer PDXs available from The Jackson Laboratory that have been extensively characterized for histopathologic features, mutational profiles, gene expression, and copy-number aberrations. Most of the PDXs are models of non–small cell lung cancer (NSCLC), including 37 lung adenocarcinoma (LUAD) and 33 lung squamous cell carcinoma (LUSC) models. Other lung cancer models in the repository include four small cell carcinomas, two large cell neuroendocrine carcinomas, two adenosquamous carcinomas, and one pleomorphic carcinoma. Models with both de novo and acquired resistance to targeted therapies with tyrosine kinase inhibitors are available in the collection. The genomic profiles of the LUAD and LUSC PDX models are consistent with those observed in patient tumors from The Cancer Genome Atlas and previously characterized gene expression-based molecular subtypes. Clinically relevant mutations identified in the original patient tumors were confirmed in engrafted PDX tumors. Treatment studies performed in a subset of the models recapitulated the responses expected on the basis of the observed genomic profiles. These models therefore serve as a valuable preclinical platform for translational cancer research.Significance:Patient-derived xenografts of lung cancer retain key features observed in the originating patient tumors and show expected responses to treatment with standard-of-care agents, providing experimentally tractable and reproducible models for preclinical investigations.
Abstract P088: Comparison Of Lay Advisor Interventions For Hypertension Across Racial Groups In The United States
Authors: Bushweller Leila , Bhayani Vishwa , Yoshida Yilin , Wilson Gwendolyn , Stange Kurt , Saper Robert , Patil Sonal 
Published: September 2022

Background:
Lay advisor interventions for hypertension are frequently tailored to a single racial group. We conducted a systematic review comparing components of lay advisor interventions for hypertension across racial groups in the US.

Methods:
Multiple databases were searched from 1980 to 2020 using relevant search terms.

Results:
Of 5986 articles, 14 studies were eligible for inclusion: 5 with predominantly white participants, 4 with Black participants, 3 with Hispanic participants and 2 with Asian participants. All studies but two were RCTs.

One study with white participants and one with Hispanic participants were clinic-based; all other studies were community-based. Lay advisors were matched to participants’ social groups in 13 studies and 1 study used health coaches with a bachelor's degree. Home visits were included in 44% (4/9) of studies with minority participants and in no studies with predominantly white participants. Most (4/5) studies with white participants included group education and one study had individual education. All studies with Black participants included only individual education. Two studies with Hispanic participants included group education while one study used health coach phone calls and home BP monitoring. Both studies with Asian participants included group education with follow-up individual education.
For BP outcomes: 3 studies with predominantly white participants, 3 with Black participants, 1 with Hispanic participants, and 2 with Asian participants showed statistically significant improvement. One health coach study with Hispanic participants showed a systolic BP reduction of 19.3 mm Hg; all other studies showed mean systolic BP improvements between 6 to 8.3 mm Hg across races. Three studies examined hypertension control outcomes, of which 2 studies with Asian participants showed improved hypertension control. Individualized low-intensity interventions were as effective as high-intensity interventions.

Conclusion:
Lay advisor interventions were effective and mainly community-based across racial groups. Individualized education by lay advisors belonging to patients’ social groups may be a feasible and effective approach for health systems that care for diverse populations.
Abstract P300: Patterns Of Adherence To Home Blood Pressure Monitoring Among Men And Women In The Electronic Framingham Heart Study
Authors: Paul Tenes J , Soni Apurv , Pathiravasan Chathurangi H , Asaker Jean-Claude , Mehawej Jordy , Filippaios Andreas , Zhang Yuankai , Sadaniantz Katherine , Wang Ziyue , Benjamin Emelia J , Liu Chunyu , Lin Honghuang , Murabito Joanne M , McManus David D , Kovell Lara 
Published: September 2022

Blood pressure (BP) measures in women more sharply increase with age compared with men, with a widening disparity in older women. The use of home blood pressure monitoring (HBPM) among women may improve this inequity. However, sex-related differences in adherence to HBPM are not well understood.
We analyzed data from electronic Framingham Heart Study participants who were given a Withings digital BP cuff and instructed to perform HBPM weekly for 1 year. Adherence was defined as ≥1 BP measurement per week, averaged over 4-week segments. HTN status was self-reported. Group-based trajectory modeling (GBTM) was used to identify trajectory patterns of adherence. We investigated the association of 3 adherence patterns with HTN status stratified by sex using multinomial logistic models adjusting for age group, marital status, education, employment status, income, non-BP cardiac medication use, subjective health, depression and anxiety.

Among 1,048 participants (59% female, mean age 53±9 years, 25% with HTN), we identified 3 trajectory groups corresponding to distinct patterns of HBPM adherence: early discontinuation (N = 458, 58% female, 21% HTN), gradual decrease (N = 360, 60% female, 27% HTN), and high adherence (N = 230, 57% female, 31% HTN,
Figure 1
). Women with HTN compared to women without HTN had 80% higher odds of being in the high adherence group versus early discontinuation group (aOR 1.80; 95% CI 1.02-3.17). This pattern was not observed for men (aOR 1.12; 95% CI 0.68-1.63).

In this middle-aged eCohort, HTN was associated with high adherence to HBPM in women but not men. The targeted prescription of HBPM for woman should be studied to see if it can reduce sex disparities in BP control.
Reservoir Pressure Integral Is Independently Associated With the Reduction in Renal Function in Older Adults
Authors: Aizawa Kunihiko , Hughes Alun D. , Casanova Francesco , Gates Phillip E. , Mawson David M. , Gooding Kim M. , Gilchrist Mark , Goncalves Isabel , Nilsson Jan , Khan Faisel , Colhoun Helen M. , Palombo Carlo , Parker Kim H. , Shore Angela C 
Published: September 2022

Background:
Arterial hemodynamic parameters derived from reservoir-excess pressure analysis exhibit prognostic utility. Reservoir-excess pressure analysis may provide useful information about an influence of altered hemodynamics on target organ such as the kidneys. We determined whether the parameters derived from the reservoir-excess pressure analysis were associated with the reduction in estimated glomerular filtration rate in 542 older adults (69.4±7.9 years, 194 females) at baseline and after 3 years.

Methods:
Reservoir-excess pressure parameters, including reservoir pressure integral, excess pressure integral, systolic, and diastolic rate constants, were obtained by radial artery tonometry.

Results:

After 3 years, and in a group of 94 individuals (72.4±7.6 years, 26 females), there was an estimated glomerular filtration rate reduction of >5% per year (median reduction of 20.5% over 3 years). A multivariable logistic regression analysis revealed that higher baseline reservoir pressure integral was independently associated with a smaller reduction in estimated glomerular filtration rate after accounting for conventional cardiovascular risk factors and study centers (odds ratio: 0.660 [95% CIs, 0.494–0.883];
P
=0.005). The association remained unchanged after further adjustments for potential confounders and baseline renal function (odds ratio: 0.528 [95% CIs, 0.351–0.794];
P
=0.002). No other reservoir-excess pressure parameters exhibited associations with the reduction in renal function.

Conclusions:
This study demonstrates that baseline reservoir pressure integral was associated with the decline in renal function in older adults at 3-year follow-up, independently of conventional cardiovascular risk factors. This suggests that reservoir pressure integral may play a role in the functional decline of the kidneys.
Meetings: The Operation of Grassroots Political Power in the Northwest Shanxi Anti-Japanese Base Area
Authors: Yue (岳靖芝) Jingzhi 
Published: September 2022

Abstract
Grassroot communities are critical fields of governance. To enhance the development of local government and to mobilize, organize, and arm the people to fight against the Japanese invaders, the Communist Party employed a number of methods in the base areas during the Anti-Japanese war. Among them, holding meetings was an effective method to get the work done and to forge leadership in local governance in the base areas, and it built a space of power that incorporated and displayed both group and individual experiences. Though the endless rounds of meetings can be seen as a kind of formalism, they provide a pivotal angle to observe the operation of power in the Northwest Shanxi Anti-Japanese Base Area. For the Communist Party, whose purpose was to reshape the countryside, the implementation of policies was far more important than their formulation. The villages were the critical places where the Party interacted with the people, where most of the meetings occurred, and where most of the policy directives were implemented. Grassroot meetings in the base areas revealed directly the willingness of the people to participate as well as their on-site performance, and indirectly the response of the people toward the Party’s policies and how the Party dealt with that response. Making decisions, mobilizing and organizing the people, and implementing policies were the basic functions of meetings. The establishment of the institution of meetings and the twists and turns of its practice reflected the gaps between the Party’s ideal and practice, and between the Party and the people.
What Does “Environmental Populism” Mean?
Authors: Sconfienza Umberto Mario 
Published: September 2022

Abstract
The current article brings together and reviews the literature on “environmental populism”; that is, environmental issues that could be explored through a populist frame. The article reviews four different cases of environmental populism: (i) right-wing populism and climate denial, (ii) resource populism, (iii) eco-populism, and (iv) the populism of environmental movements. For each case, the article analyzes how different theories of populism explain the environmental issues under consideration and how the environment is constructed. Lastly, the article argues that these four different cases only share very abstract features between them, and greater clarity would be gained by dropping the “environmental populism” label altogether in favor of “environmental populisms,” in the plural.
North China Spring Rainfall and Its Linkage with SST and Atmospheric Circulation
Authors: Shang Lin , Li Wenhong 
Published: September 2022

Abstract
Spring rainfall is important for agriculture and economics in North China (NC). Thus, there is an imperative need for accurate seasonal prediction of the spring precipitation. This study implements a novel rainfall framework to improve understanding of NC spring rainfall. The framework is built based on a three-cluster normal mixture model. Distribution parameters are sampled using Bayesian inference and a Markov chain Monte Carlo algorithm. The probability behaviors of light, moderate, and heavy rainfall events can be reflected by the three rainfall clusters, respectively. Analysis of 61-yr data indicates that moderate rainfall makes the largest contribution (67%) to the total rainfall amount. The moderate rainfall intensity is mainly influenced by the sea surface temperature anomaly (SSTA) in the previous season over the equatorial eastern Pacific, and rainfall frequency is influenced by geopotential height anomaly in the mid- to high latitudes in spring. It is also found that more extreme precipitation events can be observed in the spring following an eastern Pacific El Niño event in the previous autumn and winter. Based on these relationships, we develop a multiple linear regression model. Hindcasts for spring precipitation using the model indicates that its anomaly correlation is 0.48, significant at the 99% confidence level. The result suggests that the newly developed model can well predict spring rainfall amount in NC.
Who Believes that the Police Use Excessive Force? Centering Racism in Research on Perceptions of the Police
Authors: Drakulich Kevin , Robles Jesenia , Rodriguez-Whitney Eric , Pereira Cassidy 
Published: September 2022

Objectives Police use of excessive—even fatal—force is a significant social issue, one at the symbolic heart of the Black Lives Matter civil rights movement. However, a substantial number of Americans—disproportionately White—tend to minimize the prevalence of this issue. We seek to explain differences in these views. Methods We look at whether experiences with the police, politics, and three measures of racial attitudes explain differences in views of the prevalence of police use of excessive force, and we specifically test for whether these factors help explain racial stratification in these views. Using data from three different recent national surveys collected by the American National Election Studies, we attempt to replicate our findings within this paper. Results Views of police use of force are highly stratified by race and politics and racial attitudes—in particular racial resentment—play an important role in explaining these differences. Conclusions If we hope to address this important issue, it matters that many people minimize its existence, and it matters why they minimize it. We argue that centering race in crime and justice research necessarily means centering racism.
How UK surgeons experience burnout and the link between burnout and patient care: A qualitative investigation
Authors: Al-Ghunaim Tmam , Johnson Judith , Biyani Chandra Shekhar , O’Connor Daryl B 
Published: September 2022

Background and Aims Poor well-being affects the performance of all kinds of workers, including surgeons. This study aimed to answer two questions: (1) how does burnout affect surgeons personally, and what is their burnout experience like? (2) How does burnout affect the care that surgeons provide in the United Kingdom (UK)? Method This study conducted thematic analysis of semi-structured interviews with 14 surgeons recruited from the UK National Health Service (NHS). Result The study found three themes in surgeons’ experiences of burnout: first, burnout is common but frequently not recognised nor understood; second, burnout is a personal crisis; and third, burnout creates vulnerability at work. The study also revealed four themes related to burnout's effect on patient care: first, burnout reduces the quality of surgeon-patient relationships; second, burnout affects patient safety; third, burnout impairs staff relationships; and fourth, burnout makes surgeons less motivated to improve. Conclusion Burnout is common but not well recognised in surgeons. Improving understanding and treatment of burnout could have benefits for both surgeons themselves and the care they provide to patients.
Cardiac response to changes in central venous sonomorphology: Mechanism of impaired heart relaxation in patients with varicose veins of lower extremities
Authors: Rusinovich Yury , Rusinovich Volha 
Published: September 2022

Aim This study examines the interactions between central venous and cardiac sonomorphologies to explain the mechanism of impaired heart relaxation in patients with varicose veins of lower extremities. Material and Methods Part 1: We performed retrospective analysis of influences of inferior vena cava (IVC) diameters on tricuspid and mitral inflow and annular velocities in 64 patients with primary varicose veins. Part 2: We compared IVC diameters and IVC collapsibility index (IVC CI) in patients with varicose veins with normal values. Results We found a significant positive influence of an increase in maximal expiratory and minimal inspiratory IVC diameters on mitral and tricuspid early annular velocities or e′-waves ( p-values < .008), inflow velocities or E-waves ( p-values < .05) and early to late inflow E/A ratios ( p-values < .01). Less influenced by the changes in venous biometry ( p-values > .05) were late mitral and tricuspid inflow, annular and systolic velocities (A-, a′-, s-waves). Expiratory and inspiratory diameters in patients with varicose veins were significantly smaller ( p-values < .05 expiratory; < .0001 inspiratory), and IVC CI was significantly higher ( p-values < .0001) than the normal values. Conclusion Chronic venous disease impairs the function and the morphology of the entire inferior caval system and the heart. Impaired relaxation of the heart in patients with varicose veins is the result of two factors: (1) impaired venous return resulting in the low central venous pressure and the low early diastolic cardiac inflow; (2) structural changes in the heart resulting in the compensatory increased late diastolic cardiac inflow. Increase in central venous pressure (IVC diameters) and early diastolic cardiac inflow (E-waves), accompanied by unchanged myocardial response (e′-wave) can serve as marker for return to normal physiology.
Bedside Durable Tunneled Femoral Central Venous Catheter is Feasible and Safe in High-Risk Infants in the Pediatric Cardiac Intensive Care Unit
Authors: Shostak Eran , Tzeitlin Yelena , Shochat Tzippy , Dagan Ovadia , Schiller Ofer 
Published: September 2022

Objective Ultrasound (US)-guided durable tunneled femoral central venous catheters (TF-CVCs) are a safe central venous access option in infants and neonates. Studies have shown, however, that femoral central venous access has the potential for high central line-associated bloodstream infection (CLABSI) rates with a significant increase in risk for line-related thrombosis. Our aims were to describe the bedside insertion technique and evaluate the safety and complication rates of TF-CVCs in high-risk, young, pediatric cardiac intensive-care unit (PCICU) population. Design A retrospective observational cohort study. Setting University affiliated, tertiary-care hospital, PCICU. Patients All PCICU patients that underwent bedside TF-CVC insertion were enrolled. Data was collected from the electronic medical record system. Interventions None. Measurements and Main Results During April 2016 to October 2021, 103 TF-CVC lines were inserted into 94 pediatric cardiac critical care patients, at the bedside. Patients’ characteristics were median (IQR) age of 47.5 days (22.6, 120.5), weight 3.3 kg (2.9, 4.3), 33% prevalence of genetic anomalies, need for ECMO support in 20.4%, and STAT category 4-5 in 53.4%. All procedures were performed by intensivists. There were no immediate procedure-related complications. TF-CVCs were inserted on average on post-operative day (POD) 14, median line indwell duration was 25 days (16.3, 42.3) and total TF-CVC dwell duration for the entire cohort of 3442.7 days. During the study period eight CLABSI events were recorded (2.3/1000 line-days). Line obstruction rate was 1.16/1000 line-days and six lines were dislodged in the intermediate-care unit. There was no symptomatic line-related thrombosis. Conclusions We show that US-guided durable tunneled femoral central venous catheter (TF-CVC) insertion by an intensivist at the bedside is a technically feasible and safe prolonged central venous access option in critically ill, high-risk infants and neonates in the PCICU.
Racial/Ethnic Minority Vocational Research Trends in Counseling Psychology and Multicultural Psychology Journals: A Trend Analysis Across 51 Years
Authors: Lee Bo Hyun , Sawhney Apoorvee , Diaz David 
Published: September 2022

This study extends Flores et al.’s (2006) 36-year analysis of racial/ethnic minority (REM) vocational research published in career journals to REM vocational research in eight counseling psychology and multicultural psychology journals across a span of 51 years. We identified 483 REM vocational studies published in the Journal of Counseling Psychology (JCP), The Counseling Psychologist (TCP), Journal of Multicultural Counseling and Development (JMCD), Cultural Diversity & Ethnic Minority Psychology (CDEMP), Journal of Cross-Cultural Psychology (JCCP), Journal of Black Psychology (JBP), Journal of Latina/o Psychology (JLP), and Asian American Journal of Psychology (AAJP) between 1969 and 2020. Results showed that less than 5% of all articles published in these journals during the past 49 years focused on vocational issues with REMs. Publication trends, article topics and type, samples, and leading individual and institutional contributors to REM vocational research are reported. JMCD published the largest percentage of these articles (33.9%, n = 132) as well as the largest percentage (18%) of REM vocational articles relative to other articles in its journal during this time frame. Implications of the findings are provided for expanding REM vocational scholarship in counseling psychology in the future.
Disentangling norms, morality, and principles: the September 2019 Brexit rebellion
Authors: Stimmer Anette , Gliserman Jess 
Published: September 2022

Despite morality’s important role in international relations, we still lack a compelling way to study it. Some scholars define norms as moral in nature but fail to define morality or conceptualize it too narrowly. We address this problem by defining morality subjectively, allowing us to differentiate it from norms and study its impact on decisions of international significance. To do so, we adapt the moral convictions concept developed by psychologists to qualitative, elite-focused political research. Actors with moral convictions rely upon their individually held beliefs about fundamental right and wrong, whereas norm-followers look outward to community expectations. Morality requires sincere belief and weakens social influences.The September 2019 Brexit rebellion is an ideal case because it endangered rebels’ careers, rendering material self-interest an unlikely motive. This allows us to investigate the role of norms and moral principles. Based on interviews with British Members of Parliament (MPs) and text analysis, we find that community norms and personal moral principles interact: when existing norms give unclear guidance and identification with their in-group weakens, actors are likely to rely on their own principles to interpret norms. Morality can affect which norms matter but does not negate their influence altogether: pre-existing norms channel and constrain morality and its consequences. Many MPs moralized existing norms related to democratic decision-making, which mitigated some consequences of moralization, such as intolerance toward those with opposing views. This new conceptual and methodological approach thus helps to disentangle ideational factors and understand their influence on decisions of international significance.