bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantification of hypoxic regions distant from occlusions in cerebral penetrating arteriole trees
Authors: Xue Yidan , Georgakopoulou Theodosia , van der Wijk Anne-Eva , Józsa Tamás I. , van Bavel Ed , Payne Stephen J. 
Published: May 2022

AbstractThe microvasculature plays a key role in oxygen transport in the mammalian brain. Despite the close coupling between cerebral vascular geometry and local oxygen demand, recent experiments have reported that microvascular occlusions can lead to unexpected distant tissue hypoxia and infarction. To better understand the spatial correlation between the hypoxic regions and the occlusion sites, we used both in vivo experiments and in silico simulations to investigate the effects of occlusions in cerebral penetrating arteriole trees on tissue hypoxia. In a rat model of microembolisation, 25 µm microspheres were injected through the carotid artery to occlude penetrating arterioles. In representative models of human cortical columns, the penetrating arterioles were occluded by simulating the transport of microspheres of the same size and the oxygen transport was simulated using a Green’s function method. The locations of microspheres and hypoxic regions were segmented, and two novel distance analyses were implemented to study their spatial correlation. The distant hypoxic regions were found to be present in both experiments and simulations, and mainly due to the hypoperfusion in the region downstream of the occlusion site. Furthermore, a reasonable agreement for the spatial correlation between hypoxic regions and occlusion sites is shown between experiments and simulations, which indicates the good applicability of in silico models in understanding the response of cerebral blood flow and oxygen transport to microemboli.Author summaryThe brain function depends on the continuous oxygen supply through the bloodstream inside the microvasculature. Occlusions in the microvascular network will disturb the oxygen delivery in the brain and result in hypoxic tissues that can lead to infarction and cognitive dysfunction. To aid in understanding the formation of hypoxic tissues caused by micro-occlusions in the penetrating arteriole trees, we use rodent experiments and simulations of human vascular networks to study the spatial correlations between the hypoxic regions and the occlusion locations. Our results suggest that hypoxic regions can form distally from the occlusion site, which agrees with the previous observations in the rat brain. These distant hypoxic regions are primarily due to the lack of blood flow in the brain tissues downstream of the occlusion. Moreover, a reasonable agreement of the spatial relationship is found between the experiments and the simulations, which indicates the applicability of in silico models to study the effects of microemboli on the brain tissue.
Compartment-driven imprinting of intestinal CD4 (regulatory) T cells in inflammatory bowel disease and homeostasis
Authors: Lutter Lisanne , ter Linde José J.M. , Brand Eelco C. , van Konijnenburg David P. Hoytema , Roosenboom Britt , Talabur-Horje Carmen Horjus , Oldenburg Bas , van Wijk Femke 
Published: May 2022

AbstractObjectiveThe mucosal immune system is implicated in the etiology and progression of inflammatory bowel diseases. The lamina propria and epithelium of the gut mucosa constitute two separate compartments, containing distinct T cell populations. Human CD4 T cell programming and regulation of lamina propria and epithelium CD4 T cells, especially during inflammation, remains incompletely understood.DesignWe performed imaging mass cytometry, flow cytometry, bulk and single-cell RNA-sequencing to profile ileal lamina propria and intraepithelial CD4 T cells (CD4CD8αα, regulatory T cells (Tregs), CD69- and CD69high Trm T cells) in controls and Crohn’s disease (CD) patients (paired non-inflamed and inflamed).ResultsInflammation results in alterations of the CD4 T cell population with a pronounced increase in Tregs and migrating/infiltrating cells. On a transcriptional level, inflammation within the epithelium induced T cell activation, increased IFNγ responses and effector Treg differentiation. Conversely, few transcriptional changes within the lamina propria were observed. Key regulators including the chromatin remodelers ARID4B and SATB1 were found to drive compartment-specific transcriptional programming of CD4 T(reg) cells.ConclusionInflammation in CD patients primarily induces changes within the epithelium and not the lamina propria. Additionally, there is compartment-specific CD4 T cell imprinting, driven by shared regulators, upon translocation from the lamina propria to the epithelium. The main consequence of epithelial translocation, irrespective of inflammation, seems to be an overall dampening of broad (pro-inflammatory) responses and tight regulation of lifespan. These data suggest differential regulation of the lamina propria and epithelium, with a specific regulatory role in the inflamed epithelium.
The hidden diversity of ancient bornaviral sequences from X and P genes in vertebrate genomes
Authors: Garcia Bea Clarise B. , Mukai Yahiro , Tomonaga Keizo , Horie Masayuki 
Published: May 2022

AbstractEndogenous bornavirus-like elements (EBLs) are heritable sequences derived from bornaviruses in vertebrate genomes that originate from transcripts of ancient bornaviruses. EBLs have been detected using sequence similarity searches such as tBLASTn, whose technical limitations may hinder the detection of EBLs derived from small and/or rapidly evolving viral X and P genes. Indeed, no EBLs derived from the X and P genes of orthobornaviruses have been detected to date in vertebrate genomes. Here, we aimed to develop a novel strategy to detect such “hidden” EBLs. To this aim, we focused on the 1.9 kb read-through transcript of orthobornaviruses, which encodes a well-conserved N gene and small and rapidly evolving X and P genes. We show a series of evidence supporting the existence of EBLs derived from orthobornaviral X and P genes (EBLX/Ps) in mammalian genomes. Furthermore, we found that an EBLX/P is expressed as a fusion transcript with the cellular gene, ZNF451, which potentially encodes the ZNF451/EBLP fusion protein in miniopterid bat cells. This study contributes to a deeper understanding of ancient bornaviruses and co-evolution between bornaviruses and their hosts. Furthermore, our data suggest that endogenous viral elements detected thus far are just the tip of the iceberg, and further studies are required to understand ancient viruses more accurately.
The LC3B FRET biosensor monitors the modes of action of ATG4B during autophagy in living cells
Authors: Gökerküçük Elif Begüm , Chéron Angélique , Tramier Marc , Bertolin Giulia 
Published: May 2022

AbstractAlthough several mechanisms of autophagy have been dissected in the last decade, following this pathway in real time remains challenging. Among the early events leading to its activation, the ATG4B protease primes the key autophagy player LC3B. Given the lack of reporters to follow this event in living cells, we developed a Förster’s Resonance Energy Transfer (FRET) biosensor responding to the priming of LC3B by ATG4B. The biosensor was generated by flanking LC3B within a pH-resistant donor-acceptor FRET pair, Aquamarine/tdLanYFP. We here showed that the biosensor has a dual readout. First, FRET indicates the priming of LC3B by ATG4B and the resolution of the FRET image allows to characterize the spatial heterogeneity of the priming activity. Second, quantifying the number of Aquamarine-LC3B puncta determines the degree of autophagy activation. We then showed that there are pools of unprimed LC3B uponATG4Bdownregulation, and that the priming of the biosensor is abolished inATG4Bknockout cells. The lack of priming can be rescued with the wild-type ATG4B or with the partially active W142A mutant, but not with the catalytically dead C74S mutant. Moreover, we screened for commercially-available ATG4B inhibitors, and we illustrated their differential mode of action by implementing a spatially-resolved, broad-to-sensitive analysis pipeline combining FRET and the quantification of autophagic puncta. Finally, we uncovered the CDK1-dependent regulation of the ATG4B-LC3B axis at mitosis. Therefore, the LC3B FRET biosensor paves the way for a highly-quantitative monitoring of the ATG4B activity in living cells and in real time, with unprecedented spatiotemporal resolution.
Best practices of business process improvement: towards a representation on top of the Quintessence kernel
Authors: Vera Antonio , Zapata Carlos Mario 
Published: May 2022

PurposeOrganizational process improvement plays an important role for sustaining business in a competitive environment. Therefore, enterprise leaders are increasingly prone to adopt business process improvement (BPI) practices. However, organizations are unable to implement formal and reusable solutions, representing a gap between academic research and practical use. In addition, companies adopt discipline-dependent solutions, lacking BPI representations of best practices applicable to all organizational divisions. This paper aims to propose some constructs on top of the Quintessence kernel for representing the practice systematic development of the BPI in the BPI lifecycle and we conduct two case studies in a multinational company.Design/methodology/approachA quantitative research design was adopted for recognizing gaps in previous approaches and identifying best BPI practices. Subsequently, characterization of practices and activities are represented based on a unified definition model and the Quintessence kernel. Finally, two case studies are developed for applying the solution.FindingsThe formal representation is applicable to multiple disciplines in organizational environments. Besides, the sub-alphas (abstract level progress health attribute) states and the work products resulting from each activity completion criteria evidence the health and progress accomplished during the practice execution.Originality/valueThe practice representation serves as a formal, graphical, reusable and multidiscipline guide compiling activities and tasks for systematically developing BPI during the radical/incremental improvement lifecycle.
Managing supply chains during the Covid-19 crisis: synthesis of academic and practitioner visions and recommendations for the future
Authors: Kohl Markus , Habl Andreas , Kallali Khalil , Puff Jakob , Fottner Johannes , Oger Raphaël , Lauras Matthieu , Li Jiayao 
Published: May 2022

PurposeThe Covid-19 pandemic has created an environment of high uncertainty and caused major disruptions in supply chains. The new normal that has emerged during the pandemic is leading to a need to identify new solutions to improve supply chain crisis management in the future. Practitioners require adapted recommendations for solutions to implement. These recommendations are laid out in this paper.Design/methodology/approachA combination of a systematic literature review (SLR), qualitative semi-structured interviews and a questionnaire survey of supply chain practitioners is applied. The interviews provide insights into supply chain practitioners' views of their approaches and, together with the solutions proposed in the literature, provide future recommendations for action for supply chain managers.FindingsDuring the pandemic, companies experienced disruptions in supply, production and demand, as well as interruptions in transportation and distribution. The majority of the solutions proposed in the literature, coincide with the opinions of practitioners. These include collaborative risk management, real-time monitoring and information sharing, supply network management, scenario planning and “what-if” simulations.Research limitations/implicationsAlthough the number of interviews conducted and questionnaires completed is limited, they still serve to supplement the SLR with important practical insights and recommendations.Originality/valueThis paper presents a review of recent academic literature focusing on the impact of Covid-19 on supply chains and the existing solutions to mitigate that impact and manage future crises. It has been expanded to include industry perspectives and experiences. The findings of this study present recommended practices and strategies for better managing supply chains during a crisis.
The troubling impact of political interference in Indonesian public sector institutions on ethical leadership credibility
Authors: Eryanto Dedy , van Eeden Jones Iris , Lasthuizen Karin 
Published: May 2022

PurposeThis study investigates the impact of political interference on the capacity to combat corruption within Indonesian public sector institutions. It analyses the troubling impact of politicians in strategic leadership positions in public institutions and the impact this has on its ethical leadership credibility.Design/methodology/approachA qualitative multi-method approach was followed. Firstly, media publications were analysed to describe typical cases of corruption by political and public leaders and to evaluate the current state of the country. Secondly, the authors studied the selection and appointment processes for strategic leadership in two types of leading Indonesian public sector institutions based on laws and regulations and critical (media) publications to assess the problem of political interference. Lastly, the authors used insights from 42 face-to-face interviews within one leading public institution to understand the problem of political interference and its impact on ethical leadership credibility in Indonesia.FindingsWhen politicians are appointed in strategic leadership positions of public institutions, including CEOs, the board of directors and commissioners, the downside is that such political support causes a conflict of interest that seriously threatens the independent functioning of public institutions and the ethical reputation of the public sector as a whole. The influence of specific Indonesian cultural values and norms only reinforces these ethical challenges in building public sector integrity.Originality/valueMost empirical studies on ethical leadership focus on middle managers and the impact of ethical leadership on organisational outcomes. In addition, little is yet known about the effectiveness of ethical leadership in developing countries. This study attempts to address this gap and analyses the troubling role of politicians in strategic leadership positions in Indonesia's public institutions and the impact this has on its ethical leadership credibility.
Labor shortages during the COVID-19 and labor supply based on minimizing effort to achieve a target utility level: confounding economic policies
Authors: Cebula Richard , Foley Maggie 
Published: May 2022

Purpose
The purpose of this analysis is to explain why labor shortages may have appeared during this pandemic. Interestingly, in this COVID-19 pandemic period, the labor supply shortage could very well become more easily explained than under the traditional portrayal of consumer economic behavior. The matter seemingly lends itself to provocative empirical inquiry.

Design/methodology/approach
From this model, it can be shown that the consumer’s labor supply curve is negatively sloped and, indeed, could even assume the form of a rectangular hyperbola. Applying this model in the labor market could explain the labor shortage in the USA during the COVID-19 pandemic.

Findings
Arguably, rational consumer behavior can take the form, under a variety of circumstances (including cultural), for consumers/households that have achieved a “comfortable” standing of living/utility level, involve the minimization of work effort to achieve that utility level. In other words, constrained utility maximization is not the only rational form of consumer economic behavior. When the former behavior prevails over the latter, there are myriad implications. These do include an inverse relationship between work effort and wage rate, i.e. a negatively sloped labor supply curve.

Originality/value
This paper departs from the conventional treatment of deriving the supply curve of labor based on constrained utility maximization. Instead, it acknowledges that consumers may have a target standard of living and seek to minimize the cost of achieving that given living standard.
The role of recommender systems in fostering consumers' long-term platform engagement
Authors: Maslowska Ewa , Malthouse Edward C. , Hollebeek Linda D. 
Published: May 2022

PurposeRecommender systems (RS) are designed to communicate with users and drive consumers' engagement with the platform. However, little is known about the strength of this relationship and how RS can create stronger consumer engagement (CE) with the platform brand. Addressing this gap, this paper examines the role of RS in converting consumers' short-term engagement with the RS to their longer-term platform engagement.Design/methodology/approachTo explore these issues, the authors review key literature in the areas of CE and RS, from which they develop a conceptual framework.FindingsThe proposed framework suggests RS design as an important precursor to consumers' RS use, which is expected to affect their platform engagement/disengagement, in turn impacting the firm's long-term outcomes. The authors also identify key managerial tactics, strategies and challenges to aid the conversion of consumers' RS to CE.Research limitations/implicationsThis research raises pertinent implications for research on the RS/CE interface, as synthesized in a proposed research agenda.Practical implicationsBased on the attained insight, authors outline implications for managing, facilitating and leveraging the proposed RS to CE conversion process. Correspondingly, authors argue that, to optimize RS effectiveness, RS designers should understand the nature of CE.Originality/valueBy exploring the effect of consumers' RS on their longer-term CE with the platform, the analyses offer pioneering managerial insight into RS effectiveness from a CE perspective.
An XGBoost-based multivariate deep learning framework for stock index futures price forecasting
Authors: Wang Jujie , Cheng Qian , Dong Ying 
Published: May 2022

PurposeWith the rapid development of the financial market, stock index futures have been the one of important financial instruments. Predicting stock index futures accurately can bring considerable benefits for investors. However, traditional models do not perform well in stock index futures forecasting. This study put forward a novel hybrid model to improve the predictive accuracy of stock index futures.Design/methodology/approachThis study put forward a multivariate deep learning framework based on extreme gradient boosting (XGBoost) for stock index futures price forecasting. First, the original sequences were decomposed into several sub-sequences by variational mode decomposition (VMD), and these sub-sequences were reconstructed by sample entropy (SE). Second, the gradient boosting decision tree (GBDT) was used to rank the feature importance of influential factors, and the top influential factors were chosen for further prediction. Next, reconstructed sequence and the multiple factors screened were input into the bidirectional gate recurring unit (BiGRU) for modeling. Finally, XGBoost was used to integrate the modeling results.FindingsFor the sake of examining the robustness of the proposed model, CSI 500 stock index futures, NASDAQ 100 index futures, FTSE 100 index futures and CAC 40 index futures are selected as sample data. The empirical consequences demonstrate that the proposed model can serve as an effective tool for stock index futures prediction. In other words, the proposed model can improve the accuracy of stock index futures.Originality/valueIn this paper, an innovative hybrid model is proposed to enhance the predictive accuracy of stock index futures. Meanwhile, this method can be applied in other financial products prediction to achieve better forecasting results.
Potential blood pressure lowering effect of L-citrulline supplementation in at risk populations: a meta-analysis
Authors: Jafarnejad Sadegh , Tsang Catherine , Amin Negin 
Published: May 2022

Purpose
This paper aims to investigate the effect of L-citrulline supplementation on blood pressure (BP) in middle-aged and elderly populations.

Design/methodology/approach
Three electronic databases, namely, Google Scholar, PubMed and Scopus, were searched from 1990 to November 2020. Random effects model analysis was applied for quantitative data synthesis, and 6 trials with 150 participants were identified and included in the analysis.

Findings
Results showed an overall non-significant effect of L-citrulline supplementation on both systolic BP (SBP) and diastolic BP (DBP) in middle-aged and elderly participants. However, stratified analysis indicated a significant reduction in SBP (SMD: −0.41, 95% CI: −0.84, 0.02; p = 0.06, heterogeneity p = 0.41; I2 = 10%) but not in DBP (SMD:−0.15, 95% CI: −0.57, 0.28; p = 0.51, heterogeneity p = 0.60; I2 = 0%), following longer-term (= 8 weeks) supplementation of L-citrulline. Additionally, higher doses of L-citrulline (= 6 grams) showed a marginally significant reduction in DBP (SMD: −0.38, 95% CI: −0.78, 0.02; p = 0.06, heterogeneity p = 0.50; I2 = 0%).

Originality/value
In conclusion, a higher dosage and longer duration of supplementation with L-citrulline may have potential BP lowering effects in populations at an increased risk of hypertension
Luce Irigaray: A philosophy of teaching in ancient and modern perspective
Authors: White Richard 
Published: May 2022

Abstract
Luce Irigaray offers a powerful ‘philosophy of teaching’ that connects with the ancient paradigm. In this paper, I discuss the relationship between teaching and love as this is depicted in Plato, and I look at Irigaray's reading of the Symposium. Then I show how Irigaray's own philosophy can help us to think about the ideal teaching situation and its most essential aspects, including dialogue, difference, inspiration and embodiment. To be clear, this paper does not offer a comprehensive account of Irigaray's thought, but it extrapolates from her work on teaching and related themes such as love; and it sketches the outline of a guiding ideal, and a philosophy of teaching, which can help us in the current educational context.
The outcomes of margin status after sleeve lobectomy for patients of non–small cell lung cancer
Authors: Ren Jianghao , Zhu Mingyang , Xu Yuanyuan , Liu Ruijun , Ren Ting , Guo Zhiyi , Ren Jiangbin , Wang Kan , Tan Qiang 
Published: May 2022

AbstractBackgroundSleeve lobectomy is recognized as an alternative surgical operation to pneumonectomy because it preserves the most pulmonary function and has a considerable prognosis. In this study, we aimed to investigate the implications of residual status for patients after sleeve lobectomy.MethodsIn this retrospective cohort study, we summarized 58 242 patients who underwent surgeries from 2015 to 2018 in Shanghai Chest Hospital and found 456 eligible patients meeting the criteria. The status of R2 was excluded. The outcomes were overall survival (OS) and recurrence‐free survival (RFS). We performed a subgroup analysis to further our investigation.ResultsAfter the propensity score match, the baseline characteristic was balanced between two groups. The survival analysis showed no significant difference of overall survival and recurrence‐free survival between R0 and R1 groups (OS: p = 0.053; RFS: p = 0.14). In the multivariate Cox analysis, we found that the margin status was not a dependent risk factor to RFS (p = 0.119) and OS (p = 0.093). In the patients of R1, N stage and age were closely related to OS, but we did not find any significant risk variable in RFS for R1 status. In the subgroup analysis, R1 status may have a worse prognosis on patients with more lymph nodes examination. On further investigation, we demonstrated no differences among the four histological types of margin status.ConclusionIn our study, we confirmed that the margin status after sleeve lobectomies was not the risk factor to prognosis. However, patients with more lymph nodes resection should pay attention to the margin status.