bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shaking table investigation of a low-cost and sustainable timber-based energy dissipation system with recentering ability
Authors: Tsiavos Anastasios , Kolyfetis Dimitrios , Panzarasa Guido , Burgert Ingo , Stojadinovic Bozidar 
Published: July 2022

SummaryThe aim of this paper is to demonstrate the efficiency of a low-cost and sustainable timber-based energy dissipation system with recentering ability, which can be used as a seismic isolation system or a tuned mass damper for the seismic protection of structures in developing or developed countries. The system, defined as Dovetail with SPrings (Dove-SP), utilizes the attractive properties of timber to store CO2, thus reducing the carbon footprint of the existing energy dissipation systems: It comprises two timber slabs that are designed to slide against each other in a motion that is restrained by a dovetail sliding joint. Two sliding interfaces that allow this sliding motion at an attractively low friction coefficient are experimentally investigated: A PVC sand-wich (PVC-s) sliding interface, comprising a thin layer of sand that is sand-wiched between two PVC layers and a timber sand-wich sliding interface consisting of a thin layer of sand encapsulated between two beech timber surfaces. A set of low-cost steel springs is designed and installed on both sides of the dovetail joint to recenter the structure back to its original position after the end of an earthquake ground motion excitation. A novel, low-cost and deformable wood material fabricated from delignified balsa wood is used to reduce the pounding effects before the activation of the steel springs. The seismic behavior and the recentering ability of the novel timber-based energy dissipation system subjected to an ensemble of recorded earthquake ground motion excitations was experimentally investigated through a large-scale shaking table investigation at ETH Zurich.
Factors affecting inter-individual variability in endoxifen concentrations in patients with breast cancer: results from the prospective TOTAM trial
Authors: Braal C. Louwrens , Westenberg Justin D. , Buijs Sanne M. , Abrams Steven , Mulder Tessa A. M. , van Schaik Ron H. N. , Koolen Stijn L. W. , Jager Agnes , Mathijssen Ron H. J. 
Published: July 2022

Abstract
Introduction
Endoxifen—the principal metabolite of tamoxifen—is subject to a high inter-individual variability in serum concentration. Numerous attempts have been made to explain this, but thus far only with limited success. By applying predictive modeling, we aimed to identify factors that determine the inter-individual variability. Our purpose was to develop a prediction model for endoxifen concentrations, as a strategy to individualize tamoxifen treatment by model-informed dosing in order to prevent subtherapeutic exposure (endoxifen < 16 nmol/L) and thus potential failure of therapy.

Methods
Tamoxifen pharmacokinetics with demographic and pharmacogenetic data of 303 participants of the prospective TOTAM study were used. The inter-individual variability in endoxifen was analyzed according to multiple regression techniques in combination with multiple imputations to adjust for missing data and bootstrapping to adjust for the over-optimism of parameter estimates used for internal model validation.

Results
Key predictors of endoxifen concentration were CYP2D6 genotype, age and weight, explaining altogether an average-based optimism corrected 57% (95% CI 0.49–0.64) of the inter-individual variability. CYP2D6 genotype explained 54% of the variability. The remaining 3% could be explained by age and weight. Predictors of risk for subtherapeutic endoxifen (< 16 nmol/L) were CYP2D6 genotype and age. The model showed an optimism-corrected discrimination of 90% (95% CI 0.86–0.95) and sensitivity and specificity of 66% and 98%, respectively. Consecutively, there is a high probability of misclassifying patients with subtherapeutic endoxifen concentrations based on the prediction rule.

Conclusion
The inter-individual variability of endoxifen concentration could largely be explained by CYP2D6 genotype and for a small proportion by age and weight. The model showed a sensitivity and specificity of 66 and 98%, respectively, indicating a high probability of (misclassification) error for the patients with subtherapeutic endoxifen concentrations (< 16 nmol/L). The remaining unexplained inter-individual variability is still high and therefore model-informed tamoxifen dosing should be accompanied by therapeutic drug monitoring.
Plk2-mediated phosphorylation and translocalization of Nrf2 activates anti-inflammation through p53/Plk2/p21cip1 signaling in acute kidney injury
Authors: Kim Da-Eun , Byeon Hye Eun , Kim Dae-Hoon , Kim Sang Geon , Yim Hyungshin 
Published: July 2022

Abstract
The Plk2 is a cellular stress-responsive factor that is induced in response to oxidative stress. However, the roles of Plk2 in acute kidney injury (AKI) have not been clarified. We previously found that Plk2 is an interacting factor of Nrf2 in response to cellular stress, since Plk2 is upregulated in the Nrf2-dependent network. Here, we show that the levels of p53, Plk2, p21cip1, and chromatin-bound Nrf2 were all upregulated in kidney tissues of mice or NRK52E cells treated with either cisplatin or methotrexate. Upregulation of Plk2 by p53 led to an increase of Nrf2 in both soluble and chromatin fractions in cisplatin-treated NRK52E cells. Consistently, depletion of Plk2 suppressed the levels of Nrf2. Of note, Plk2 directly phosphorylated Nrf2 at Ser40, which facilitated its interaction with p21cip1 and translocation into the nuclei for the activation of anti-oxidative and anti-inflammatory factors in response to AKI. Together, these findings suggest that Plk2 may serve as an anti-oxidative and anti-inflammatory regulator through the phosphorylation and activation of Nrf2 to protect kidney cells from kidney toxicants and that Plk2 and Nrf2 therefore work cooperatively for the protection and survival of kidney cells from harmful stresses.
EmbAssi: embedding assignment costs for similarity search in large graph databases
Authors: Bause Franka , Schubert Erich , Kriege Nils M. 
Published: July 2022

AbstractThe graph edit distance is an intuitive measure to quantify the dissimilarity of graphs, but its computation is $$\mathsf {NP}$$
NP
-hard and challenging in practice. We introduce methods for answering nearest neighbor and range queries regarding this distance efficiently for large databases with up to millions of graphs. We build on the filter-verification paradigm, where lower and upper bounds are used to reduce the number of exact computations of the graph edit distance. Highly effective bounds for this involve solving a linear assignment problem for each graph in the database, which is prohibitive in massive datasets. Index-based approaches typically provide only weak bounds leading to high computational costs verification. In this work, we derive novel lower bounds for efficient filtering from restricted assignment problems, where the cost function is a tree metric. This special case allows embedding the costs of optimal assignments isometrically into $$\ell _1$$

ℓ
1

space, rendering efficient indexing possible. We propose several lower bounds of the graph edit distance obtained from tree metrics reflecting the edit costs, which are combined for effective filtering. Our method termed EmbAssi can be integrated into existing filter-verification pipelines as a fast and effective pre-filtering step. Empirically we show that for many real-world graphs our lower bounds are already close to the exact graph edit distance, while our index construction and search scales to very large databases.
Academic reading as a social practice in higher education
Authors: Afdal Hilde W. , Spernes Kari , Hoff-Jenssen Reidun 
Published: July 2022

AbstractIn this study, an undergraduate teacher education course is used to explore whether and how academic reading seminars reflect the theoretical notion of academic literacies and provide a learning environment for developing academic and professional learning and engagement. The data analyzed in this article are transcribed recordings of small group activities where students discuss scientific articles based on a template. First, our empirical analysis shows that the use of the template facilitated dialogical discussions and the development of a cognitive skillset and disciplinary categories when used in a social setting. Second, we found that the most challenging part of designing a reading practice related to the academic literacies tradition was fostering a dialogical environment for discussing the validity of findings across different contexts and provide for discussions encompassing complexity, nuances, and meaning making. We found traces of such discussions in all the transcripts; however, many examples were in a premature stage. The paper concludes with a discussion on, and some suggestions for, further development of the template used in the reading seminars.
Agency of Subjects and Eye Movements in Schizophrenia Spectrum Disorders
Authors: Barattieri di San Pietro Chiara , de Girolamo Giovanni , Luzzatti Claudio , Marelli Marco 
Published: July 2022

AbstractPeople with schizophrenia spectrum disorders (SSD) show anomalies in language processing with respect to “who is doing what” in an action. This linguistic behavior is suggestive of an atypical representation of the formal concepts of “Agent” in the lexical representation of a verb, i.e., its thematic grid. To test this hypothesis, we administered a silent-reading task with sentences including a semantic violation of the animacy trait of the grammatical subject to 30 people with SSD and 30 healthy control participants (HCs). When the anomalous grammatical subject was the Agent of the event, a significant increase of Gaze Duration was observed in HCs, but not in SSDs. Conversely, when the anomalous subject was a Theme, SSDs displayed an increased probability of go-back movements, unlike HCs. These results are suggestive of a higher tolerability for anomalous Agents in SSD compared to the normal population. The fact that SSD participants did not show a similar tolerability for anomalous Themes rules out the issue of an attention deficit. We suggest that general communication abilities in SSD might benefit from explicit training on deep linguistic structures.
Myosin assembly of smooth muscle: from ribbons and side polarity to a row polar helical model
Authors: Sobieszek Isabel J. , Sobieszek Apolinary 
Published: July 2022

AbstractAfter decades of debate over the structure of smooth muscle myosin filaments, it is still unclear whether they are helical, as in all other muscle types, or square in shape. In both cases bipolar building units are proposed, but the deduced cross-bridge arrangements are fundamentally different. The opposite polarity of the adjusting longitudinal rows is proposed for the helical structure, while in the case of square filaments, or myosin ribbons, only their two faces are appositively polarized. Analysis of our unpublished archival data on light meromyosin (LMM) paracrystals and myosin rod assemblies as well as the filaments themselves indicated that the rods were assembled with a 6°–7° tilt angle from the rods’ longitudinal axis, in contrast to the lack of tilt in LMM, both exhibiting a 14.3 nm myosin periodicity. Optical diffraction analysis of EM images of the rod assemblies and those of intact myosin confirmed their helical architecture characterized by 28 nm residue translations, 172 nm repeats and 516 nm pitch. A detailed helical model of these filaments was elucidated with bipolar tetramer building units made of two polar trimers. The filaments elongate at their two ends in a head-to-head manner, enabling targeted cross-bridge polarity of the adjacent rows, in the form of a unique Boerdijk–Coxeter type helix, similar to that of collagen or desmin fibers, with the covalent links replaced by a head-to-head clasp.
Rotation on the digital plane
Authors: Hannusch Carolin , Pethő Attila 
Published: July 2022

AbstractLet $$A_{\varphi }$$

A
φ

denote the matrix of rotation with angle $$\varphi $$
φ
of the Euclidean plane, FLOOR the function which rounds a real point to the nearest lattice point down on the left and ROUND the function for rounding off a vector to the nearest node of the lattice. We prove under the natural assumption $$\varphi \not = k\frac{\pi }{2}$$

φ
≠
k

π
2

that the functions $${{\,\mathrm{FLOOR}\,}}\circ A_{\varphi }$$

FLOOR

∘

A
φ

and $${{\,\mathrm{ROUND}\,}}\circ A_{\varphi }$$

ROUND

∘

A
φ

are neither surjective nor injective. More precisely we prove lower and upper estimates for the size of the sets of lattice points, which are the image of two lattice points as well as of lattice points, which have no preimages. It turns out that the densities of those sets are positive.
An efficient medical image encryption scheme for (WBAN) based on adaptive DNA and modern multi chaotic map
Authors: Abdelfatah Roayat Ismail , Saqr Hager Mohamed , Nasr Mohamed E. 
Published: July 2022

AbstractA Wireless Body Area Network (WBAN) is a network of wireless sensor nodes that can be installed inside or outside of the human body. This network is crucial in medical problems. Due to storage, battery power, and computational resource limitations, the security of medical information such as medical photographs or other information is a major concern in (WBAN). This work proposes an image encryption approach that addresses these constraints by utilizing adaptive DNA code bases and a new multi chaotic map architecture. DNA coding is used to enhances computing efficiency and gives great data transfer capabilities and the new multi chaotic map was formed by Combining Henon, Gaussian and Logistic map (HGL) To generate more chaotic pseudo-random sequences. Numerous analyses were conducted to test the proposed scheme, such as brute force, statistical, differential assaults and noise added analysis. Results indicated that this scheme has a strong level of security.
Comparative Study of Influence of Experimental Configuration on Densities of Active Species in the Early Afterglows of N2/(0–2.5%)H2 HF Flowing Plasmas
Authors: Abdeladim M. , Sarrette J. P. , Amorim J. , Ricard A. 
Published: July 2022

AbstractAfterglows of mixed gas of N2 and H2(0–2.5%) flowing microwave discharges in a 5 mm diameter tube connected to a 5 L reactor via a tube of 1.8 cm diameter and 50 cm long, have been studied using optical emission spectroscopy. The obtained results at the entrance of the afterglow tube of 1.8 cm diameter: Short time afterglow (SA), (10–3 s) and inside the 5 L reactor: Long time afterglow (LA), (10–2 s) were then compared. It was found that, in N2 at 2 Torr, 0.5 slpm, the active specie density ratios had a constant value of 10–2 for N/N2, but decreased respectively from 10–3 to 10–4 for N2 (X,v > 13)/N2 and from 10–6 to 10–8 for N+2 /N2. By directly connecting the discharge tube inside the 5 L reactor, the density increases by 10 for N2 (X,v > 13) and by 102 for N2+ by changing the afterglow from LA(10−2 s) to a SA(10–3 s). Moreover and by adding 1% of H2 to N2, the N/N2 and H/H2 ratios had constant values of 1% and 0.2% respectively. The SA(10–3 s) appeared to be more efficient for surface treatments than the LA (10–2 s).
Barriers and enablers to switching from a solid to a liquid formulation of Parkinson’s medication: a theory-based mixed methods investigation
Authors: Atkins Bethany , Bhattacharya Debi , Smith Caroline , Scott Sion 
Published: July 2022

Abstract
Background
Swallowing tablets/capsules can become difficult and dangerous for People with Parkinson’s (PwP) who develop oropharyngeal dysphagia. Switching to a liquid delays the need for progressing to last line patches/injections. However, liquids are rarely used therefore a change in prescribing practice is warranted but, as with any change in behaviour, may be met with resistance.

Aim
To characterise PwPs and carers’ barriers and enablers (determinants) of switching from solid to liquid Parkinson’s medication formulations.

Method
Underpinned by the Theoretical Domains Framework, focus groups with PwPs and carers were convened to identify determinants of switching, which were then used to develop a questionnaire distributed across the UK. Determinants were prioritised if ≥ 50% of respondents agreed/strongly agreed that they were important to their decision to switch to a liquid formulation. Percentage precisions were reported as 95% confidence intervals.

Results
From three focus groups and 131 questionnaires responses, PwPs and carers prioritised nine determinants. Three enablers had almost unanimous agreement: liquids’ flexibility for incremental dosing (72% ± 8); decline in Parkinson’s control (72% ± 8); prescriber’s endorsement to switch (70% ± 8). The barriers: perception that tablets/capsules are easier to dose than liquids (72% ± 8); and prescriber’s opposition to switching (70% ± 8), attracted similarly high agreement.

Conclusion
There is a desire to switch to liquids when Parkinson’s progresses and for their use beyond this to offer flexibility in dosing, a previously unrecognised indication for switching. The only notable resistance to switching may be addressed by innovations from the pharmaceutical industry to make liquids easier to measure.
Embodying the Face: The Intersubjectivity of Portraits and Self-portraits
Authors: Gallese Vittorio 
Published: July 2022

AbstractThe topic of the human face is addressed from a biocultural perspective, focusing on the empirical investigation of how the face is represented, perceived, and evaluated in artistic portraits and self-portraits from the XVth to the XVIIth century. To do so, the crucial role played by the human face in social cognition is introduced, starting from development, showing that neonatal facial imitation and face-to-face dyadic interactions provide the grounding elements for the construction of intersubjective bonds. The neuroscience of face perception is concisely presented and discussed, together with the psychophysics of face perception and gaze exploration, introducing the notions of the left visual field advantage (LVFA) and the left gaze bias (LGB). The results of experiments on the perception and the emotional and aesthetic rating of artistic portraits and self-portraits are reported, showing that despite participants’ inability to tell self-portraits and portraits apart, greater emotional, communicative-social, and aesthetic ratings were attributed to self-portraits. It is concluded that neuroscience and experimental aesthetics can contribute to better understand the human face, hence to better understand ourselves.
Reminiscence therapy-based care program serves as an optional nursing modality in alleviating anxiety and depression, improving quality of life in surgical prostate cancer patients
Authors: Huang Ting , Su Hongmei , Zhang Shi , Huang Yawen 
Published: July 2022

Abstract
Purpose
Reminiscence therapy is reported to attenuate the psychological disorders in cancer patients, such as colorectal and lung cancer patients. However, relevant report on surgical prostate cancer patients is scarce. This study put forward a reminiscence therapy-based care program (RTCP + UC) combing reminiscence therapy with usual care (UC), and aimed to evaluate the impact of RTCP + UC on anxiety, depression, quality of life and survival in surgical prostate cancer patients.

Methods
Totally, 108 prostate cancer patients receiving surgical resection were enrolled, who were subsequently randomized and allocated to the RTCP + UC group (N = 55) and UC group (N = 53) at a 1:1 ratio. Hospital Anxiety and Depression Scale (HADS) and QLQ-C30 were assessed at month M0, M3, M6, M9 and M12 during the intervention period. After intervention, patients were followed up for another 24 months to calculate disease-free survival (DFS) and overall survival (OS).

Results
RTCP + UC decreased HADS-anxiety score at M9 and M12, declined HADS-depression score at M6, M9 and M12, reduced depression rate and the severity level of depression at M12, while did not affect these issues at other time points. Meanwhile, RTCP + UC enhanced the QLQ-C30 global health status score at M3, M6, M9 and M12, but did not influence the QLQ-C30 function score and QLQ-C30 symptom score at any time points. Meanwhile, RTCP + UC had no effect on the accumulating DFS and OS of surgical prostate cancer patients.

Conclusion
RTCP + UC serves as an optional nursing modality in alleviating anxiety and depression, improving quality of life in surgical prostate cancer patients.
Prävention des plötzlichen Kindstods
Authors: Singh H. , Jeßberger J. , Zeeb H. 
Published: July 2022

Zusammenfassung
Hintergrund
Der plötzliche Kindstod (SIDS, „sudden infant death syndrome“) ist dank vieler Präventionsmaßnahmen heute deutlich seltener als noch vor ca. 30 Jahren. Wir führten einen schnellen systematischen Review zu effektiven Interventionsmaßnahmen durch und evaluierten ein mehrjähriges Präventionsprojekt in Hamm.

Methodik
Für den Review wurde eine systematische Recherche in der Datenbank PubMed durchgeführt. Eingeschlossen wurden alle ab 2004 (auf Deutsch oder Englisch) veröffentlichten Ergebnisberichte von Interventionen zur SIDS-Prävention (n = 17 Artikel). Für die Evaluationsstudie wurden im Praxisbetrieb erhobene Befragungsdaten von Eltern Neugeborener der Jahre 2011–2018 ausgewertet. Direkt nach der Geburt und ca. 3 Monate später wurden die Eltern mündlich und schriftlich über SIDS-Präventionsmaßnahmen aufgeklärt und zur geplanten und umgesetzten Schlafsituation befragt. Die Ergebnisse wurden deskriptiv ausgewertet.

Ergebnisse
Ergebnisse des Reviews bestätigen die gute Umsetzbarkeit der Rückenlage als Schlafposition. Weniger häufig werden der Literatur zufolge Verhaltensempfehlungen zur Schlafumgebung des Säuglings und zum Rauchverhalten im Haushalt umgesetzt. Beim Projekt SIDS Hamm wurde eine empfohlene Schlafumgebung bei 46 % und die Rückenlage bei 90 % der Säuglinge angegeben. Empfehlungen zur Schlafposition (Odds Ratio [OR]: 1,33; 95 %-Konfidenzintervall [KI]: 1,03–1,72) und zur Schlafumgebung (OR: 1,42; KI: 1,16–1,74) wurden eher eingehalten, wenn eine ärztliche SIDS-Aufklärung erfolgte.

Diskussion
In der internationalen Literatur werden Defizite bei Umsetzung der empfohlenen Schlafumgebung und beim Rauchverhalten in der SIDS-Prävention beschrieben. Das Präventionsprojekt in Hamm konnte durch unterschiedliche Ansätze der Wissensvermittlung dazu beitragen, dass viele Eltern SIDS-präventive Maßnahmen umsetzten und so das Risiko des plötzlichen Kindstods weiter verringern.
Lagena—an overlooked oomycete genus with a wide range of hosts
Authors: Thines Marco , Buaya Anthony T. 
Published: July 2022

AbstractLagena has so far only been known from the scarcely reported but widespread species Lagena radicicola, which is a parasite of root epidermal cells. While it was mostly reported from a wide range of cereals and other grasses, it has been shown to affect some dicot species under, e.g. tobacco and sugar beet. Due to the wide host spectrum under laboratory conditions, there were no attempts to subdivide the genus into several species, even though some morphological differentiation was reported and the species had been found in several continents. During a survey of diatoms, we came across some parasitoids that would have previously been assumed to be members of the genus Lagenidium. The species exhibited rather narrow host specificity in nature. One species was brought into dual culture with host diatoms of the genus Ulnaria, but could not be transferred to other host genera. Surprisingly, phylogenetic analyses revealed that Lagena radicicola was in a sister clade to that formed by the diatom parasitoids, suggesting a versatile pathogenicity of the genus. Interestingly, several phylogenetic lineages only known from environmental sequencing were clustered with the species found in this study, hinting an undiscovered diversity in the genus Lagena.