bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly immune-related genes of breast cancer: potential diagnostic and prognostic biomarkers
Authors: Yang Beibei , Chen Xi , Zhang Wei , Zou Liqun 
Published: December 2022

Abstract

Although immune checkpoint inhibition (ICI) has shown therapeutic promise in breast cancer, there is considerable heterogeneity in its efficacy. Therefore, our study aimed to explore effective biomarkers for identifying patients most likely to benefit from immunotherapy. In our study, differentially expressed genes from the Cancer Genome Atlas breast cancer dataset were first identified using the R package limma; they were then intersected with the list of immune-related genes obtained from the ImmPort and InnateDB databases to obtain 542 immune-related differentially expressed genes for breast cancer. Twelve immune-related hub genes and three independent prognostic genes (S100B,NPR3, andSDC1) were then identified by weighted gene coexpression network analysis and multivariate Cox regression analysis, respectively. Furthermore, the accuracy of the prognosis prediction model (IRGRS) constructed by these three genes (S100B, NPR3, and SDC1) for breast cancer patients was further verified in four GEO data sets. In addition, we predicted the matrix and immune components in the high- and low-risk scores groups, and found that the low-risk score group had a higher Immune Score and a better prognosis. The drug response prediction analysis also found that the IC50 values of Bleomycin, Gemcitabine, Lapatinib, and Paclitaxel were lower in the low-risk score group than in the high-risk score group. The IRGRS constructed in this study may potentially differentiate the prognostic, molecular, and immunological features of breast cancer.
The benefits of music therapy on preterm infants in the intensive care unit
Authors: Leivas Kayene Alcântara , Ramos Laís Zanchetta , Piperno Giulia Caroline , Alves Ana Flávia de Jesus , Kawata Cíntia , Sabino Henrique Augusto Cantareira , Molinari Beatriz Carmona 
Published: December 2022

Abstract
This clinical study seeks to demonstrate the benefits that music therapy (MT) can provide, by the analysis of heart rate (HR), respiratory rate, peripheral oxygen saturation and the Neonatal Facial Coding System (NFCS) pain scale on preterm (PT) neonates hospitalized in the neonatal intensive care unit, where they are exposed to factors which are stressful and harmful to their health. During the period between March and September 2022, each hospitalized PT neonate was submitted to a single 20 minutes music therapy session with non-classical instrumental music without voice. A total of 17 PT neonates were included in the analysis of this study. The data collected demonstrated that MT was beneficial in stabilizing vital signs with an average reduction in HR of 12 beats per minute during the therapy (p = 0.012).
Conclusion: Music therapy is capable of stabilizing vital signs such as heart rate in a single session and reducing the stress of the neonate.
Cost-utility analysis of eribulin versus capecitabine in HER-2 negative advanced or metastatic breast cancer in China
Authors: Hong Wanglong , Shen Aizong 
Published: December 2022

Abstract
Objective: To evaluate the cost-utility of eribulin versus capecitabine in the treatment of HER-2 negative advanced or metastatic breast cancer(AMBC).
Methods: Based on the data of a phase III trial, a partition survival modelwas constructed with a study duration of 10 years. Uncertainty analysis were used to evaluate the robustness of the results.
Results: The results showed that compared with capecitabine group, the eribulin group obtained 0.24 more QALY, spent $5287.11 more, and ICUR was $22084.93/QALY, which was less than the threshold. uncertainty analysis showed that the results were robust, and the probability of eribulin being cost-utility is 69.28% at the threshold of $33881.17.
Conclusions: Eribulin is cost-utility than capecitabine in the treatment of HER-2 negative AMBC.
Association of Serum Neurofilament Light Chain with Depressive Symptoms: a population-based study
Authors: Zhang Hui 
Published: December 2022

Abstract
Background
Neurofilament light chain proteins (NfL) are widely accepted biomarkers of neuronal injury, and depressive symptoms are related to neuronal injury. Nevertheless, evidences of the association between NfL and depressive symptoms are still limited. This is the first population-based study to examine the association between NfL and depressive symptoms in general population.
Methods
We included 1907 participants with measurement of serum NfL from the 2013–2014 U.S. National Health and Nutrition Examination Survey. Depressive symptoms were measured by the 9-item Patient Health Questionnaire. Logistic regression models were conducted to examine associations between serum NfL levels and depressive symptoms. Restricted cubic spline regressions were applied to estimate the possible nonlinear relationships between them.
Results
Increased serum NfL were associated with higher risk of depressive symptoms after adjusted for confounder factors (per SD: odds ratios [OR] = 1.16, 95% confidence intervals [CI]: 1.02–1.34). Individuals with higher serum NfL (> 21.8 pg/ml, the upper 20% quantile) had a higher likelihood of depressive symptoms compared to normal counterparts (OR = 1.50, 95% CI: 1.01–2.22), and sensitivity analysis using different grouping criteria provided similar results. Furthermore, restricted cubic spline regression analysis demonstrated that a near-linear association occurred between serum NfL and the risk of depressive symptoms (P-nonlinear = 0.681, P-overall < 0.001).
Conclusions
This study found linear association between serum NfL levels and depressive symptoms in general population. Our findings support that serum NfL levels may be a novel biomarker for depressive symptoms, further studies are needed to validate our findings underlying this association.
Comparison of Visual Performance between Monofocal and Rotationally Asymmetric Refractive Intraocular Lenses
Authors: Miyoshi Masaki , Tanabe Hirotaka , Shojo Tomohiro , Yamauchi Tomofusa , Takase Kosuke , Tabuchi Hitoshi 
Published: December 2022

Abstract
We compared the visual performance of a monofocal intraocular lens (IOL) (ZCB00) and a rotationally asymmetric refractive IOL with + 1.5 diopters near addition (Lentis Comfort LS-313 MF15) by investigating postoperative parameters ten weeks after surgery from both eyes of cataract patients who underwent bilateral implantation with one of the two IOLs within three months between 2011 and 2019. A total of 1352 eyes of 676 patients were enrolled; the ZCB00 group comprised 904 eyes of 452 patients (72.3 ± 6.8 years; females/males, 268/184), and the LS-313 MF15 group included 448 eyes of 224 patients (73.6 ± 7.0 years; females/males, 125/99). A linear mixed-effects model using data for both eyes, with strict adjustments for sex, age, subjective refraction spherical equivalent, subjective refraction cylinder, corneal astigmatism, axial length, corneal higher-order aberrations, and pupil diameter, ensured statistical validity. Corrected distance visual acuity was significantly better, and the higher-order aberrations (ocular/internal, scaled to a 4/6-mm pupil; WF_4_post_O_TotalHOA, _Third, _Fourth, _Trefoil, _Coma, _Tetrafoil, _Spherical; WF_4_post_I_TotalHOA, _Third, _Fourth, _Trefoil, _Coma, _Tetrafoil, _Spherical, WF_6_post_O_Spherical, and WF_6_post_I_Spherical) were significantly smaller in the ZCB00 group (p < 0.00068, Wald test). Contrast sensitivity with glare (6.3 degrees) and spectacle independence (near) were significantly better in the LS-313 MF15 group (p < 0.00068, Wald test).
Intermittent water supply in Indian cities: considering the intermittency beyond demand and supply
Authors: Satpathy Suchismita , Jha Rohit 
Published: December 2022

Abstract
Intermittent water supply (IWS) is a typical characteristic of cities in developing countries like India. One of the factors responsible for IWS is unaccounted for water (UFW). Factors like increase in population, upward trends in water demand, water scarcity due to climate change, and asymmetric distribution of water resources are also equally important. However, social relations of water are poorly understood and camouflaged under technicalities associated with IWS. Thus, in this paper, we examine IWS in Indian mega cities and secondary cities with an ethno-economic framework by bringing the data together from various administrative sources like government agencies, allude to its parameters from logistical perspectives, e.g. distances, capacities, population strength, etc., and try to position the water issue with challenges associated with caste, class, gender, religion, region, and governance. The ethno-economic perspective is an attempt to not only complement but also supplement the scientific studies from other disciplines by understanding the real nature of demand and supply problems in urban water management. This paper demonstrates IWS as a multi-dimensional problem and stresses the human drivers of intermittency.
Repurposing of Chemotherapeutics to Combat COVID-19
Authors: Nandi Sisir , Nayak Bhabani Shankar , Khede Mayank Kumar , Saxena Anil Kumar 
Published: December 2022

Abstract:
Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is a novel strain of SARS coronavirus. The COVID-19 disease caused by this virus was declared a pandemic by the World Health Organization (WHO). SARS-CoV-2 mainly spreads through droplets sprayed by coughs or sneezes of the infected to a healthy person within the vicinity of 6 feet. It also spreads through asymptomatic carriers and has negative impact on the global economy, security and lives of people since 2019. Numerous lives have been lost to this viral infection; hence there is an emergen-cy to build up a potent measure to combat SARS-CoV-2. In view of the non-availability of any drugs or vaccines at the time of its eruption, the existing antivirals, antibacterials, antimalarials, mu-colytic agents and antipyretic paracetamol were used to treat the COVID-19 patients. Still there are no specific small molecule chemotherapeutics available to combat COVID-19 except for a few vac-cines approved for emergency use only. Thus, the repurposing of chemotherapeutics with the poten-tial to treat COVID-19 infected people is being used. The antiviral activity for COVID-19 and bio-chemical mechanisms of the repurposed drugs are being explored by the biological assay screening and structure-based in silico docking simulations. The present study describes the various US-FDA approved chemotherapeutics repositioned to combat COVID-19 along with their screening for bio-logical activity, pharmacokinetic and pharmacodynamic evaluation.
The Role of Nrf2 in Relieving Cerebral Ischemia-Reperfusion Injury
Authors: Sun Yu , Yang Xu , Xu Lijun , Jia Mengxiao , Zhang Limeng , Li Peng , Yang Pengfei 
Published: December 2022

Abstract:
Ischemic stroke includes two related pathological damage processes: brain injury caused by
primary ischemia and secondary ischemia reperfusion (I/R) injury. I/R injury has become a worldwide
health problem. Unfortunately, there is still a lack of satisfactory drugs for ameliorating cerebral I/R
damage. Nrf2 is a vital endogenous antioxidant protein, which combines with Keap1 to maintain a
dormant state under physiological conditions. When pathological changes such as I/R occurs, Nrf2
dissociates from Keap1 and activates the expression of downstream antioxidant proteins to exert a protective
effect. Recent research have shown that the activated Nrf2 not only effectively inhibits oxidative
stress, but also performs the ability to repair the function of compromised mitochondria, alleviate
endoplasmic reticulum stress, eliminate inflammatory response, reduce blood-brain barrier permeability,
inhibit neuronal apoptosis, enhance the neural network remolding, thereby exerting significant protective
effects in alleviating the injuries caused by cell oxygen-glucose deprivation, or animal cerebral
I/R. However, no definite clinical application report demonstrated the efficacy of Nrf2 activators in the
treatment of cerebral I/R. Therefore, further efforts are needed to elaborate the role of Nrf2 activators
in the treatment of cerebral I/R. Here, we reviewed the possible mechanisms underlying its potential
pharmacological benefits in alleviating cerebral I/R injury, so as to provide a theoretical basis for
studying its mechanism and developing Nrf2 activators.
Substance use Specificities in Women with Psychosis: A Critical Review
Authors: Casanovas Francesc , Fonseca Francina , Mané Anna 
Published: December 2022

Background:
Women with schizophrenia or other psychotic disorders differ from male patients
in many respects, including psychopathology, prognosis, disease course, and substance use
comorbidities. Most studies performed to date to investigate the association between drug use and
psychosis have not evaluated gender differences, although this has started to change in recent years.

Methods:
We briefly summarize the available evidence on gender differences in drug use and substance
use disorders (SUD) in psychotic patients during the early phases of the psychotic illness and
during the course of schizophrenia.

Results:
Substance use and SUD are both less prevalent in women, both in the general population and
at all phases of the psychotic spectrum. Some studies suggest that SUD may be under diagnosed in
female patients, in part due to their more vulnerable profile. Substance use, especially cannabis, may
more negatively impact females, especially on the disease course and prognosis. The available data
suggest that it may be more difficult to treat SUD in female patients with schizophrenia, which could
negatively impact prognosis.

Conclusion:
Women with concomitant psychotic illness and SUD comprise a highly vulnerable subgroup.
This should be considered when selecting the treatment approach, especially in the early phases
of the illness, to ensure better outcomes.
Combined Experimental and Theoretical Spectroscopic Properties (FT-IR, FT-Ra, Uv-Vis, and NMR), DFT Studies, Biological Activity, Molecular Docking, and Toxicity Investigations of 3-methoxy-1-piperazinylbenzene
Authors: Kucuk Ceyhun , Yurdakul Senay , Erdem Belgin 
Published: December 2022

Background:Piperazine and its derivatives have many important pharmacological properties such as antimicrobial, antituberculosis, anticancer, antiviral, and antimalarial activity, as well as HIV protease inhibitors and antidepressant activity. Therefore, the structural, spectroscopic, electronic, optic, and thermodynamic properties, and biological activity of the 3-methoxy-1- piperazinylbenzene molecule, which is a piperazine derivative, were investigated in this study.Methods:Theoretical calculations for ligands were carried out with the DFT method by using B3LYP /6-311++G(d,p) basis set except for NMR calculations. NMR analyses were calculated with 6-311++G(2d,p) and were recorded experimentally.Results:Experimental and calculated frequencies are compared and they are in agreement with each other. Also, the Uv-Vis absorbance spectrum for the title molecule was recorded and calculated. They were found to be in harmony with each other. According to the results of molecular orbital analysis and other quantum chemical properties, this molecule has low reactivity and stability. The reactive areas of the ligand were investigated by using MEP map, Fukui functions, and electronic charge analyses, and also performing ELF and LOL analysis. As a result of all these analysis methods, electrophilic regions of the molecule were found to be similar. Some thermodynamic properties at different temperatures and non-linear optical properties were investigated. The increase in enthalpy and entropy values depending on the temperature rise indicates that the thermodynamic structure of the molecule has changed. Also, this molecule has an important non-linear optical response.Conclusion:In biological activity and toxicity studies, the title molecule has an activity against microorganisms and a good drug score.
“Phardiacare” Program for Improved Medication Adherence and Clinical
Outcomes of Type 2 Diabetes Mellitus Patients in Community Health
Centers
Authors: Pradhyta Ferna Putri , Sartika Ratu Ayu Dewi , Sauriasari Rani 
Published: December 2022

Background:
The role of pharmacists in middle-income countries such as Indonesia is
still not optimal. In this study, we developed a program called “Phardiacare”, a specific
pharmacist-led program for Type 2 diabetes mellitus (T2DM) patients.

Objective:
The objective of this study is to assess the effectiveness of the application of the
“Phardiacare” program in improving medication adherence and clinical outcomes in T2DM
patients.

Methods:
The study was quasi-experimental, with a pretest-posttest design, and was conducted
prospectively from July to October 2019 at the Matraman and Jatinegara District Health Center,
Jakarta, Indonesia. The study comprised 33 T2DM patients in an intervention group (IG) who
received the “Phardiacare” program and 33 patients in a control group (CG). Assessment was performed
of HbA1c, FBG, LDL, HDL, total cholesterol, triglycerides, and blood pressure.

Results:
HbA1c after intervention in the IG was lower than that of the CG (p <0.05). Intra-group
mean differences showed improvement in the clinical parameters of FBG, triglycerides, and
diastolic blood pressure in the IG (p <0.05), but not in the CG. Other clinical parameters did not
show significant improvement. The results of the multivariate analysis showed that the
“Phardiacare” program had a 16 times greater effect in reducing levels of HbA1c in the IG [95%
CI 3.995:67.113, p <0.001] compared to the CG, even after controlling for confounding variables.

Conclusion:
The “Phardiacare” program was effective in improving patient medication adherence
by decreasing HbA1c and FBG, but it did not have a significant effect on LDL, HDL, total
cholesterol, and systolic blood pressure. Therefore, the implementation of Phardiacare program in
the management of chronic diseases, especially T2DM, should be considered.
Cone Beam CT Features and Oral Radiologist’s Decision-making of
Arrested Pneumatization of the Sphenoid Sinus
Authors: Alsufyani Noura , Alsuayri Nouf , Alrasheed Raghad 
Published: December 2022

Objectives:
To assess the demographic and radiographic features of arrested pneumatization of the sphenoid sinus (APS) and their influence on the confidence of oral and maxillofacial radiologists (OMFRs) in diagnosing APS.

Methods:
Reports of cone beam computed tomography (CBCT) APS were retrieved, and the demographic and radiographic features were retrospectively analyzed. Five OMFRs assessed the CBCT images and their confidence in diagnosing APS. The OMFRs’ experience (years), expertise (skull-base CBCT cases/month) and diagnostic confidence level were analyzed for agreement and associations with demographic or radiographic features.

Results:
Of 29 APS cases, 17 (58.6%) were women, and the mean age was 29.9±19 years. Twenty cases (69.0%) presented unilaterally, and 27 (93.1%) involved the sphenoid body. The most common accessory site was the pterygoid process (19, 65.5%). The vidian canal and foramen rotundum were involved in 27 (93.1%) and 17 (58.6%) cases, respectively. Most cases (28, 96.6%) were well-defined, corticated, and showed mixed attenuation. APS diagnostic confidence was higher among the expert OMFRs (72.4%–82.8% vs. 58.6%–62.1%).

Conclusion:
Radiographic features differentiating APS from skull-base tumors were shown on CBCT. The confidence of OMFRs with similar experience in years depended on their frequency of examining CBCT cases involving the skull base.
In silico-Based Structural Prediction, Molecular Docking and ADMET
Analysis of Novel Imidazo-Quinoline Derivatives as Pf Purine Nucleoside
Phosphorylase Inhibitors
Authors: Mallick Chaitali , Mishra Mitali , Asati Vivek , Kashaw Varsha , Das Ratnesh , Kashaw Sushil Kumar 
Published: December 2022

Introduction:
The prolonged antimalarial therapy with the marketed drug has developed
multi-resistant strains of Plasmodium parasites that emerge as a consequential global problem.
Therefore, designing new antimalarial agents is an exclusive solution to overcome the alarming
situation.

Methods:
The integrated computational perspectives, such as pharmacophore mapping, 3D-QSAR
and docking studies have been applied to improve the activity of the imidazo-quinoline scaffold.
The best hypothesis AARRR_1 (Survival score 5.4609) obtained through pharmacophore mapping
revealed that imidazo-quinoline scaffold is found to be vital for antimalarial activity. The significant
CoMFA (q2 = 0.728, r2 = 0.909) and CoMSIA (q2 = 0.633, r2 = 0.729) models, developed by
using molecular field analysis with the PLS method, showed good predictive ability with r2
pred values
of 0.9127 and 0.7726, respectively. Docking studies were performed using Schrodinger and
GOLD software with the Plasmodium falciparum purine nucleoside phosphorylase enzyme (PDB
ID-5ZNC) and results indicated that the imidazo-quinoline moiety facilitates the interaction with
Tyr 160.

Results:
In addition, some compounds are screened from the ZINC database based on structural
requirements to verify the relevance of the research. Finally, designed molecules and ZINC database
compounds were screened through the ADMET tool to evaluate pharmacokinetic and druglikeness
parameters.

Conclusion:
Thus, these exhaustive studies suggested that established models have good predictability
and would help in the optimization of newly designed molecules that may lead to potent antimalarial
activity for getting rid of resistance issues.
EXTRACTION AND CHARACTERIZATION OF BLACK BETEL LEAF (PIPER ACRE BLUME.) ESSENTIAL OILS FROM EAST KALIMANTAN
Authors: MAULIDYA VINA , HASANAH ALIYA NUR , RIJAI LAODE , MUCHTARIDI MUCHTARIDI 
Published: December 2022

Objective: To determine the extraction technique and content of linalool, as the dominant compound, in black betel essential oil from East Kalimantan using a validated analytical method.
Methods: Extraction was carried out using steam distillation. Essential oils were assessed by observing the colour and solubility in ethanol. Using an Agilent GC-MS with a 5977B (GCMSD) detector, a DB-5MS column, and a helium gas carrier of 1 ml/minute. The level of dominant compounds was determined using a validated analytical method.
Results: The essential oil had characteristics that met SNI standards. Based on the results of GC-MS, the dominant compound in five samples was linalool. Validation of the analytical method was carried out with the following conditions established: injector temperature 250 °C, oven temperature 40 °C with a 2 min holding time, reaching 125 °C with a 10 min holding time, reaching 250 °C with a 2 min holding time, reaching 340 °C with a 10 min holding time. The resulted in a linearity of 0.999; a 1.637% relative standard deviation for precision; 102.27% recovery value for accuracy; 0.4% LOD; and 1.2% LOQ. The percentage linalool content of the samples was found in the sample code MADSH 4 (10.56% with a standard deviation of 0.6169).
Conclusion: The steam distillation extraction method can be used to obtain essential oil with characteristics that meet SNI standards. Based on the results of GC-MS, linalool is the dominant compound, with a concentration of 10.56% found in the MADSH4 sample.