bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐dose chemotherapy for relapsed germ cell tumours: outcomes in low‐volume specialized centres
Authors: Connolly Elizabeth A. , Weickhardt Andrew , Grimison Peter , Asher Rebecca , Heller Gillian Z. , Lewin Jeremy , Liow Elizabeth , Toner Guy , Tung Iris L.Y. , Tran Ben , Hill Sean , Walpole Euan , McKenzie Jane , Kuchel Anna , Goh Jeffrey , Forgeson Garry , Tan Alvin , Joshi Abhishek , Wickham Alistair , Tan Hsiang , Wang Yang , Winstanley Mark A. , Hamad Nada , Wong Vanessa 
Published: March 2022

ObjectiveTo report treatment patterns and survival outcomes of patients with relapsed and refractory metastatic germ cell tumours (GCTs) treated with high‐dose chemotherapy (HDCT) and autologous stem‐cell transplantation in low‐volume specialized centres within the widely dispersed populations of Australia and New Zealand between 1999 and 2019.Patients and MethodsWe conducted a retrospective analysis of 111 patients across 13 institutions. Patients were identified from the Australasian Bone Marrow Transplant Recipient Registry. We reviewed treatment regimens, survival outcomes, deliverability and toxicities. Primary endpoints included overall (OS) and progression‐free survival (PFS). Cox proportional hazards models were used to test the association of survival outcomes with patient and treatment factors.ResultsThe median (range) age was 30 (14–68) years and GCT histology was non‐seminomatous in 84% of patients. International Prognostic Factors Study Group (IPFSG) prognostic risk category was very low/low, intermediate, high and very high in 18%, 36%, 25% and 21% of patients, respectively. Salvage conventional‐dose chemotherapy (CDCT) was administered prior to HDCT in 59% of patients. Regimens included paclitaxel, ifosfamide, carboplatin and etoposide (50%), carboplatin and etoposide (CE; 28%), carboplatin, etoposide and ifosfamide (CEI; 6%), carboplatin, etoposide and cyclophosphamide (CEC; 5%), CEC‐paclitaxel (6%) and other (5%). With a median follow‐up of 4.4 years, the 1‐, 2‐ and 5‐year PFS rates were 62%, 57% and 52%, respectively, and OS rates were 73%, 65% and 61%, respectively. There were five treatment‐related deaths. Progression on treatment occurred in 17%. In a univariable analysis, worse International Germ Cell Cancer Collaborative Group (IGCCCG) and IPFSG prognostic groups were associated with inferior survival outcomes. An association of inferior survival was not found with the number of high‐dose cycles received nor when HDCT was delivered after salvage CDCT.ConclusionThis large dual‐national registry‐based study reinforces the efficacy and deliverability of HDCT for relapsed and refractory metastatic GCT in low‐volume specialized centres in Australia and New Zealand, with survival outcomes comparable to those found in international practice.
Parental sensitivity and child behavioral problems: A meta‐analytic review
Authors: Cooke Jessica E. , Deneault Audrey‐Ann , Devereux Chloe , Eirich Rachel , Fearon R. M. Pasco , Madigan Sheri 
Published: March 2022

AbstractMeta‐analytic associations between observed parental sensitivity and child behavioral problems were examined (children aged 0–17 years). Studies (k = 108, N = 28,114) contained sociodemographically diverse samples, primarily from North America and Europe, reporting on parent‐child dyads (95% mothers; 54% boys). Sensitivity significantly related to internalizing (k = 69 studies; N = 14,729; r = −.08, 95% CI [−.12, −.05]) and externalizing (k = 94; N = 25,418; r = −.14, 95% CI [−.17, −.11]) problems, with stronger associations found for externalizing. For internalizing problems, associations were significantly stronger among samples with low socioeconomic status (SES) versus mid‐high SES, in peer‐reviewed versus unpublished dissertations, and in studies using composite versus single scale sensitivity measures. No other moderators emerged as significant.
Cutaneous malakoplakia with verruciform xanthoma in the same lesion
Authors: Xu Zhijun , Pei Xiaoping , Huang Lining , Xue Ruzeng 
Published: March 2022

AbstractCutaneous malakoplakia (CM) is a rare, chronic, granulomatous disease characterized histopathologically by Michaelis–Gutmann bodies (MGB). Verruciform xanthoma (VX) is a rare, benign lesion characterized histopathologically by epithelial papillomatous hyperplasia, local hyperkeratosis with incomplete keratosis, infiltration of foam cells and inflammatory cells in the papillary dermis. We present an elderly Chinese man with CM and coexisting VX with histological confirmation of MGB.
Phylogeny and biogeography of the northern temperate genus Dracocephalum s.l. (Lamiaceae)
Authors: Chen Ya‐Ping , Turdimatovich Turginov Orzimat , Nuraliev Maxim S. , Lazarević Predrag , Drew Bryan T. , Xiang Chun‐Lei 
Published: March 2022

AbstractThe northern temperate genus Dracocephalum consists of approximately 70 species mainly distributed in the steppe‐desert biomes of Central and West Asia and the alpine region of the Qinghai‐Tibetan Plateau (QTP). Previous work has shown that Dracocephalum is not monophyletic and might include Hyssopus and Lallemantia. This study attempts to clarify the phylogenetic relationships, diversification patterns, and the biogeographical history of the three genera (defined as Dracocephalum s.l.). Based on a sampling of 66 taxa comprising more than 80% from extant species of Dracocephalum s.l., morphological, phylogenetic (maximum parsimony, likelihood, and Bayesian inference based on nuclear ITS and ETS, plastid rpl32‐trnL, trnL‐trnF, ycf1, and ycf1‐rps15, and two low‐copy nuclear markers AT3G09060 and AT1G09680), molecular dating, diversification, and ancestral range estimation analyses were carried out. Our results demonstrate that both Hyssopus and Lallemantia are embedded within Dracocephalum and nine well‐supported clades can be recognized within Dracocephalum s.l. Analyses of divergence times suggest that the genus experienced an early rapid radiation during the middle to late Miocene with major lineages diversifying within a relatively narrow timescale. Ancestral area reconstruction analyses indicate that Dracocephalum s.l. originated in Central and West Asia and southern Siberia, and dispersed from Central and West Asia into the QTP and adjacent areas twice independently during the Pliocene. The aridification of the Asian interior possibly promoted the rapid radiation of Dracocephalum within this region, and the uplift of the QTP appears to have triggered the dispersal and recent rapid diversification of the genus in the QTP and adjacent regions. Combining molecular phylogenetic and morphological evidence, a revised infrageneric classification of Dracocephalum s.l. is proposed, which recognizes nine sections within the genus.
Effects of skin washing frequency on the epidermal barrier function and inflammatory processes of the epidermis: An experimental study
Authors: Symanzik Cara , Kezic Sanja , Jakasa Ivone , Skudlik Christoph , John Swen Malte , Brans Richard , Sonsmann Flora Karla 
Published: March 2022

AbstractBackgroundIncreased hand hygiene measures during the COVID‐19 pandemic have led to an increased quantum of hand eczema (HE).ObjectivesTo examine the effects of varying washing frequencies using current mild cleansing agents—alongside with the effect of a rehydrating cream—on the epidermal barrier function and inflammatory processes of the stratum corneum(SC).MethodsStandardized skin washings on the volar aspects of the lower arms of skin‐healthy volunteers were performed using the automated cleansing device either 5 or 11 times within 4 h for 60 s each with a standard cleanser, a lipid‐containing syndet, or a lipid‐containing syndet followed by one‐time application of a rehydrating cream. Skin bioengineering parameters (transepidermal water loss, SC hydration, erythema, and SC pH) and biochemical/immunological parameters (interleukin‐1α, interleukin‐1α receptor antagonist and natural moisturizing factor) of SCsamples collected by tape stripping were assessed.ResultsAll applied washing procedures provided comparable, mild effects on the epidermal barrier function and skin inflammation.ConclusionOccupational skin cleansers seem to have improved regarding skin barrier damaging effects. To further corroborate this, a study design, modified on the basis of our findings, applying longer washing periods for consecutive days seems desirable.
Priority conservation areas for Cedrus atlantica in the Atlas Mountains, Morocco
Authors: Cheddadi Rachid , Taberlet Pierre , Boyer Frédéric , Coissac Eric , Rhoujjati Ali , Urbach Davnah , Remy Cécile , Khater Carla , el Antry Salwa , Aoujdad Jalila , Carré Matthieu , Ficetola Gentile Francesco 
Published: March 2022

AbstractAssessing biodiversity loss and species extinction is necessary to warn society and raise awareness of the impacts of ongoing climate change. Prioritizing protected areas is the pragmatic and applicable management measure under the pressure of ongoing climate change and limited resources to conserve species at risk of extinction. We developed a novel conservation index (CI) to prioritize areas and populations of an endangered mountain tree species that need protection in the face of ongoing climate change, as conservation of all populations may not be realistic. This CI integrates (1) mountain topography to identify potential refugial areas with suitable microclimates, (2) genetic diversity to assess the adaptive capacity of local populations, and (3) hypothetical climate change in the species' range. We applied this CI to Atlas cedar, an endemic and threatened species whose populations are scattered throughout the Moroccan mountains. This index provided a scale for 33 populations studied and suggests that genetically diverse populations located in rugged areas where future local climate may overlap with their current climatic niche should receive a higher conservation priority. This index may also be applicable to other mountain species with scattered populations and is likely to be more accurate if more precise climate data are used at the microrefugia scale.
Clinical and genetic characteristics of late‐onset Huntington's disease in a large European cohort
Authors: Petracca Martina , Di Tella Sonia , Solito Marcella , Zinzi Paola , Lo Monaco Maria Rita , Di Lazzaro Giulia , Calabresi Paolo , Silveri Maria Caterina , Bentivoglio Anna Rita 
Published: March 2022

AbstractBackground and purposeHuntington's disease (HD) is an autosomal dominant condition caused by CAG‐triplet repeat expansions. CAG‐triplet repeat expansion is inversely correlated with age of onset in HD and largely determines the clinical features. The aim of this study was to examine the phenotypic and genotypic correlates of late‐onset HD (LoHD) and to determine whether LoHD is a more benign expression of HD.MethodsThis was a retrospective observational study of 5053 White European HD patients from the ENROLL‐HD database. Sociodemographic, genetic and phenotypic variables at baseline evaluation of subjects with LoHD, common‐onset HD (CoHD) and young‐onset HD (YoHD) were compared. LoHD subjects were compared with healthy subjects (HS) aged ≥60 years. Differences between the CoHD and LoHD groups were also explored in subjects with 41 CAG triplets, a repeat number in the lower pathological expansion range associated with wide variability in age at onset.ResultsLate‐onset HD presented predominantly as motor‐onset disease, with a lower prevalence of both psychiatric history and current symptomatology. Absent/unknown HD family history was significantly more common in the LoHD group (31.2%) than in the other groups. The LoHD group had more severe motor and cognitive deficits than the HS group. Subjects with LoHD and CoHD with 41 triplets in the larger allele were comparable with regard to cognitive impairment, but those with LoHD had more severe motor disorders, less problematic behaviors and more often an unknown HD family history.ConclusionsIt is likely that cognitive disorders and motor symptoms of LoHD are at least partly age‐related and not a direct expression of the disease. In addition to CAG‐triplet repeat expansion, future studies should investigate the role of other genetic and environmental factors in determining age of onset.
Linking ecological niche models and common garden experiments to predict phenotypic differentiation in stressful environments: Assessing the adaptive value of marginal populations in an alpine plant
Authors: Morente‐López Javier , Kass Jamie M. , Lara‐Romero Carlos , Serra‐Diaz Josep M. , Soto‐Correa José Carmen , Anderson Robert P. , Iriondo José M. 
Published: March 2022

AbstractEnvironmental variation within a species’ range can create contrasting selective pressures, leading to divergent selection and novel adaptations. The conservation value of populations inhabiting environmentally marginal areas remains in debate and is closely related to the adaptive potential in changing environments. Strong selection caused by stressful conditions may generate novel adaptations, conferring these populations distinct evolutionary potential and high conservation value under climate change. On the other hand, environmentally marginal populations may be genetically depauperate, with little potential for new adaptations to emerge. Here, we explored the use of ecological niche models (ENMs) linked with common garden experiments to predict and test for genetically determined phenotypic differentiation related to contrasting environmental conditions. To do so, we built an ENM for the alpine plant Silene ciliata in central Spain and conducted common garden experiments, assessing flowering phenology changes and differences in leaf cell resistance to extreme temperatures. The suitability patterns and response curves of the ENM led to the predictions that: (1) the environmentally marginal populations experiencing less snowpack and higher minimum temperatures would have delayed flowering to avoid risks of late‐spring frosts and (2) those with higher minimum temperatures and greater potential evapotranspiration would show enhanced cell resistance to high temperatures to deal with physiological stress related to desiccation and heat. The common garden experiments revealed the expected genetically based phenotypic differentiation in flowering phenology. In contrast, they did not show the expected differentiation for cell resistance, but these latter experiments had high variance and hence lower statistical power. The results highlight ENMs as useful tools to identify contrasting putative selective pressures across species ranges. Linking ENMs with common garden experiments provides a theoretically justified and practical way to study adaptive processes, including insights regarding the conservation value of populations inhabiting environmentally marginal areas under ongoing climate change.
Effect of lactosucrose on the evaluation of visual appearance, texture, water mobility, microstructure and inhibition of staling in wheat bread
Authors: Zhang Miaomiao , Xiao Shensheng , Gong Aqiong , Liu Xiaorong , Wu Yan , Du Jing , Ding Wenping , Fu Yang , Wang Xuedong 
Published: March 2022

SummaryStarch retrogradation occurred in the process of storage of bread, resulting in a decreased product quality. The aim of this research was to determine the effect of lactosucrose on bread baking and anti‐staling properties. The results showed that the addition of lactosucrose increased the specific volume and slice cell number with a higher air holding capacity. The kinetic equation showed that lactosucrose reduced the rate constant value. Besides, the long‐ and short‐range ordered structure showed that the incorporation of lactosucrose retarded the crystallisation rate, in which the water migration was delayed. This effect was also evident on the microstructure, indicating that lactosucrose could improve the quality of bread and delay the staling of bread, which provided new insights for the baking industry.
Effects of partial substitution of potato flour on cooking characteristics, texture properties and in vitro starch digestibility of fresh extruded rice‐shaped kernels
Authors: Li Lu , Li Xuejin , Li Dandan , Liu Zhenyuan , Yan Yiming , Chen Lan , Li Xihong 
Published: March 2022

SummaryEffects of partial substitution of potato flour (0%, 10%, 20%, 30% and 40%) for rice flour on cooking characteristics, textural properties and in vitro starch digestibility of fresh extruded rice‐shaped kernels (FER). With the increase in potato flour content, the water absorption index (WAI) increased gradually, the water solubility index (WSI) decreases gradually. Hardness, elasticity, adhesion and chewiness first increased and then decreased. When the potato flour content was 30%, the peak viscosity, trough viscosity, breakdown viscosity, final viscosity and setback viscosity of the pasting test were 325, 168, 157, 312 and 144 cp, respectively. The WAI of the cooking test was 7.50 g g−1, and the WSI was 4.71%. The texture test had a hardness of 1211.82 g, flexibility of 0.85 mm, cohesiveness of 0.73 gs, adhesion of 715.38 g and chewiness of 519.28 g. The highest overall acceptability score was 4.51 in sensory evaluation. Finally, the predicted glycaemic index indicated that potato flour is a suitable raw material for low GI products.
Vaginal transmission causes prolonged Zika virus shedding in the vaginal mucosa and delays systemic dissemination
Authors: Balint Elizabeth , Somani Armaan Amin , Giles Elizabeth C , Feng Emily , Vahedi Fatemeh , Ashkar Ali A 
Published: March 2022

AbstractZika virus (ZIKV) has emerged as a significant health threat worldwide. Although typically mosquito‐borne, recent evidence suggests that ZIKV is also a sexually transmitted virus. While persistent ZIKV infections in male reproductive tissues have been identified, little is understood regarding the outcomes of primary sexual transmission in females. We investigated how the route of infection affects vaginal ZIKV shedding and dissemination. In two mouse models, vaginal infection resulted in prolonged ZIKV shedding in the vaginal mucosa with delayed systemic infection. Furthermore, heightened vaginal inflammation did not influence ZIKV replication or dissemination, in contrast to previous studies of mosquito‐borne infection. Thus, vaginal infection significantly alters ZIKV infection kinetics and must be considered when developing novel treatments.
Sliding scale insulin use in a national cohort study of nursing home residents with type 2 diabetes
Authors: Lam Kenneth , Gan Siqi , Nguyen Brian , Jing Bocheng , Lee Sei J. 
Published: March 2022

AbstractBackgroundGuidelines discourage sliding scale insulin (SSI) use after the first week of a nursing home (NH) admission. We sought to determine the prevalence of SSI and identify factors associated with stopping SSI or transitioning to another short‐acting insulin regimen.MethodsIn an observational study from October 1, 2013, to June 30, 2017 of non‐hospice Veterans Affairs NH residents with type 2 diabetes and an NH admission over 1 week, we compared the weekly prevalence of SSI versus two other short‐acting insulin regimens – fixed dose insulin (FDI) or correction dose insulin (CDI, defined as variable SSI given alongside fixed doses of insulin) – from week 2 to week 12 of admission. Among those on SSI in week 2, we examined factors associated with stopping SSI or transitioning to other regimens by week 5. Factors included demographics (e.g., age, sex, race/ethnicity), frailty‐related factors (e.g., comorbidities, cognitive impairment, functional impairment), and diabetes‐related factors (e.g., HbA1c, long‐acting insulin use, hyperglycemia, and hypoglycemia).ResultsIn week 2, 21% of our cohort was on SSI, 8% was on FDI, and 7% was on CDI. SSI was the most common regimen in frail subgroups (e.g., 18% of our cohort with moderate–severe cognitive impairment was on SSI vs 5% on FDI and 4% on CDI). SSI prevalence decreased steadily from 21% to 16% at week 12 (p for linear trend <0.001), mostly through stopping SSI. Diabetes‐related factors (e.g., hyperglycemia) were more strongly associated with continuing SSI or transitioning to a non‐SSI short‐acting insulin regimen than frailty‐related factors.ConclusionsSSI is the most common method of administering short‐acting insulin in NH residents. More research needs to be done to explore why sliding scale use persists weeks after NH admission and explore how we can replace this practice with safer, more effective, and less burdensome regimens.
Integration of future water scarcity and electricity supply into prospective LCA: Application to the assessment of water desalination for the steel industry
Authors: Baustert Paul , Igos Elorri , Schaubroeck Thomas , Chion Laurent , Mendoza Beltran Angelica , Stehfest Elke , van Vuuren Detlef , Biemans Hester , Benetto Enrico 
Published: March 2022

AbstractThe urgency of tackling global environmental issues calls for radical technological and behavioral changes. New prospective (or ex ante) methods are needed to assess the impacts of these changes. Prospective life cycle assessment (LCA) can contribute by detailed analysis of environmental consequences. A new stream of research has taken up the challenge to create prospective life cycle inventory (LCI) databases, building on projections of integrated assessment models to describe future changes in technology use and their underlying environmental performance. The present work extends on this by addressing the research question on how to project life cycle impact assessment methods for water scarcity consistent with prospective LCI modeling. Water scarcity characterization factors are projected from 2010–2050 using the AWARE method, based on SSP‐RCP scenario results of the integrated assessment model IMAGE. This work is coupled with prospective LCI databases, where electricity datasets are adapted based on the energy component of IMAGE for the same scenario. Based on this, an LCA case study of water desalination for the steel industry in Spain is presented. The resulting regional characterization factors show that some regions (i.e., the Iberian Peninsula) could experience an increase in water scarcity in the future. Results of the case study show how this can lead to trade‐offs between climate change and water scarcity impacts and how disregarding such trends could lead to biased assessments. The relevance and limitations are finally discussed, highlighting further research needs, such as the temporalization of the impacts.
Decolonising cultural environmental monitoring in Aotearoa New Zealand: Emerging risks with institutionalisation and how to navigate them
Authors: Tadaki Marc , Astwood Jenna‐Rose , Ataria Jamie , Black Morry , Clapcott Joanne , Harmsworth Garth , Kitson Jane 
Published: March 2022

AbstractCultural monitoring of the environment has emerged in Aotearoa New Zealand as a mechanism to revitalise Indigenous knowledge and support Treaty‐based governance. While cultural monitoring is increasingly salient in environmental policy, there is a need to proceed with awareness about how institutionalisation of cultural monitoring can modify or constrain its intent. Here, we dissect the genealogies and principles of cultural monitoring, identifying how cultural monitoring has been folded into the logic of ‘state of the environment’ reporting. By investigating three examples of cultural monitoring, we analyse how different institutional mechanisms enable and constrain the realisation of cultural monitoring's decolonising intent.