bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Mannanase Supplementation and Citric Acid on the Growth Performance of Broilers
Authors: Arellano Maria Patricia , Purnamasari Listya , Dela Cruz Joseph 
Published: September 2022

The study was conducted to evaluate the effects of citric acid and mannanase feed supplementation on the growth performance of broiler chickens. Three hundred twenty day-old unsexed Cobb broiler chicks from a commercial hatchery plant were used in the study. The chicks were randomly assigned to four treatment groups following a completely randomized design. The following treatment groups were used: T1: Control, T2: 3% (w/w) Citric Acid supplementation, T3: 80 ppm β-Mannanase supplementation, and T4: 3% (w/w) Citric Acid and 80 ppm β-Mannanase supplementation. The supplementation of citric acid and mannanase significantly improves the growth performance of broiler chickens. Body weight and body weight gain were significantly higher (P&lt;0.05) in the citric acid and β-mannanase combination group compared to all the treatment groups. The evaluation of feed intake revealed that T3 and T4 had significantly lower (P&lt;0.05) feed intake than the other groups. The combination of citric acid and β-Mannanase also resulted in a significantly more efficient (P&lt;0.05) feed conversion ratio. No mortality was observed during the experiment. It may be concluded that the supplementation of citric acid and β- mannanase resulted in a better performance in broilers.
Vascularized Medial Femoral Condyle Periosteal Flaps With Allograft Bone for Distal Radius Giant Cell Tumors
Authors: Talwar Abhinav , Bai Jennifer , Wester James R. , Attar Samer , Peabody Terrance D. , Ko Jason H. 
Published: September 2022

Case:
Distal radius reconstruction after giant cell tumor (GCT) resection is typically performed with free fibular flaps when a vascularized bone is needed. However, vascularized fibular flaps are contraindicated in patients with peroneal artery variants. We present 2 patients with GCTs of the radius and bilateral peronea arteria magna who underwent resection with wrist fusion using an allograft bone and vascularized free medial femoral condyle periosteal flaps. Both patients had excellent outcomes with minimal postoperative morbidity.

Conclusion:
Allograft bone with vascularized medial femoral condyle periosteal flaps is an effective option for reconstructing distal radius defects after GCT resection when conventional methods fail.
Unusual Anatomic Location of the Median Nerve Within the Pronator Teres Muscle
Authors: Yarbrough Ben , Chan Peter Y.W. , Tan Virak 
Published: September 2022

Case:
A 57-year-old man presented with pain and paresthesia in both hands and was diagnosed with pronator teres syndrome. Surgical decompression of the left elbow and forearm revealed the median nerve in an unusual anatomic location, specifically running within the pronator teres muscle.

Conclusion:
Anatomic anomalies of the pronator teres muscle and the path of the median nerve have been described. However, there are no reports of the median nerve entering and traveling within the pronator teres. Surgeons should be aware of this anomaly to avoid potential iatrogenic injury when performing an anterior surgical approach to the elbow and proximal forearm.
Tularemia Proximal Interphalangeal Joint Septic Arthritis
Authors: Clary Steven J. , Brubacher Jacob W. , Kubat Ryan C. 
Published: September 2022

Case:
A case of Francisella tularensis finger proximal interphalangeal joint septic arthritis secondary to feral cat bite is presented. The patient underwent operative debridement on presentation. On postoperative day 5, a gram-negative rod resembling F. tularensis was identified. The patient received 4 weeks of gentamicin for culture-confirmed ulceroglandular tularemia. At the final follow-up, the infection had resolved, and full function of the digit had been regained.

Conclusion:

Francisella tularensis septic arthritis secondary to a feral cat bite is exceedingly rare but should be considered in the appropriate clinical context. Proper identification and treatment with antibiotics is essential for a positive outcome.
High-resolution structures and conformational dynamics of RNA origami during folding
Authors: Andersen Ebbe , McRae Ewan , Rasmussen Helena , Liu Jianfang , Bøggild Andreas , Nguyen Michael , Vallina Nestor , Boesen Thomas , Pedersen Jan Skov , Ren Gang (Gary) , Geary Cody 
Published: September 2022

Abstract
Cotranscriptional folding of RNA is a fundamental self-assembly process of nature, important for the biological assembly of complex molecular machines like the ribosome. Inspired by this folding process, we developed the cotranscriptional RNA origami design method to efficiently produce RNA nanostructures by enzymatic synthesis, advantageous for large-scale production in vitro or expression in vivo. However, advancing this technology further will require high-resolution characterization and a better understanding of the cotranscriptional folding process. Here, we use cryogenic electron microscopy to study a panel of RNA origami structures at local resolutions up to 3.4 Å, revealing details of kissing loop and crossover structural modules used to compose RNA origami. The derived structural parameters are used to reduce internal strain and global twist to obtain more ideal shapes. In three-dimensional bundle designs, we discover a novel kinetic folding trap that forms during cotranscriptional folding, and is only released 6-8 hours after transcription. Finally, pushing both scale and complexity, we design the first multi-domain RNA origami and characterize the conformational variability of its domains by individual particle electron tomography. Our results improve understanding of RNA structure, dynamics, and folding, providing a basis for future applications of cotranscriptional folding in RNA medicine and synthetic biology.
Direction-Guided Two-Stream Convolutional Neural Networks for Skeleton-Based Action Recognition
Authors: su benyue , Zhang Peng , Sun Manzhen , Sheng Min 
Published: September 2022

Abstract
In skeleton-based action recognition, the approach of treating skeleton data as pseudo-images using convolutional neural networks (CNN) has proven to be effective. However, among the existing CNN-based approaches, most of them focus on modeling information at the joint-level ignoring the size and direction information of the skeleton edges, which play an important role in action recognition, and these approaches may not be optimal. In addition, combining the directionality of human motion to portray the motion variations information of the action, which is more natural and reasonable for action sequence modeling, is rarely considered in existing approaches. In this work, we propose a novel direction-guided two-stream convolutional neural networks (DG-2sCNN) for skeleton-based action recognition. On the first stream, our model focuses on our defined edge-level information (including edge and edge\_motion information) with directionality in the skeleton data to explore the spatio-temporal features of the action. On the second stream, since the motion is directional, we define different skeleton edge directions and extract different motion information (including translation and rotation information) in different directions in order to better exploit the motion features of the action. Besides, we propose the description of human motion inscribed by a combination of translation and rotation, and explore the way they are integrated. We conducted extensive experiments on two challenging datasets, NTU-RGB+D 60 and NTU-RGB+D 120, to verify the superiority of our proposed method over state-of-the-art methods. The experimental results demonstrate that the proposed direction-guided edge-level information and motion information complement each other for better action recognition.
Environmental life cycle assessment of large-scale coal mining with annual output of more than one million tonnes
Authors: Tao Ming , Cheng Wenqing , Wu Chengqing , Shi Ying 
Published: September 2022

Abstract

Coal occupies an absolute advantage in the primary energy structure of China. However, the production of coal poses a serious threat to the ecological environment and human health. In order to quantify the environmental impact of coal mining, this study used the life cycle assessment (LCA) method to analyse the life cycle of coal mining from the cradle- to-gate. Midpoint results based on ReCiPe 2016 indicated that coal mining had a remarkable impact on human carcinogenic toxicity, marine ecotoxicity, freshwater ecotoxicity, fossil resource scarcity, and human non-carcinogenic toxicity. The contribution analysis revealed that material production was identified as the main cause of environmental impacts, followed by energy consumption and process emissions. Steel consumption, electricity production and wastewater discharge were identified as key environmental pollution processes. In addition, specific environmental pollution substances and their contributions were recognized from the source, and sensitivity analysis between key processes and key impact categories was carried out. At the endpoint level, coal mining led to the most damage to human health, followed by ecosystems and resources. This study is of reference significance in guiding the construction of green mines and achieving sustainable development of coal resources.
Adjunctive Drug-Loaded Gel Application in the Treatment of Periodontitis: A Systematic Evaluation and Meta-Analysis
Authors: Li Zhige , Yang Xin , Wang Jiao , Meng Yucheng , Qin Ziyang , Zhang Baoping 
Published: September 2022

AbstractBackground This meta-analysis aimed to assess and systematically investigate the efficacy of drug-loaded gel adjuncts in the treatment of periodontitis based on relevant literature. Methods Six databases including the China National Knowledge Infrastructure, WanFang Data, VIP Chinese Science and Technology Periodical Database, China Biology Medicine disc, Cochrane library, PubMed, and Web of Science were searched from the establishment of the database until December 2021 for randomized controlled trials (RCTs) that studied the application of drug-loaded gel in periodontitis treatment. The meta-analysis was conducted using Stata 15.0 and Review Manager 5.4 for articles that met the criteria. Results The study included nine RCTs involving 706 participants. Periodontal probing depth (PPD) and clinical attachment level (CAL) were the primary and secondary outcomes, respectively. The subgroup analyses performed for PPD (standardized mean difference [SMD] = 0.59, 95% confidence interval [CI]=[0.44, 0.73], I2 = 48.0%, p = 0.05) and CAL (SMD = 0.58, 95% CI=[0.34, 0.82], I2 = 61.0%, p = 0.005) of follow-up period revealed that the heterogeneity (p) among groups of each indicator is 0.98 and 0.96, respectively. The gel component was analyzed as another subgroup factor, reflected by heterogeneity (p = 0.23) among groups and Egger test (p = 0.794) in PPD, while the results of those in CAL were 0.1 and 0.079, respectively. Conclusion The application of drug-loaded gel as an adjunctive therapy for periodontitis resulted in effectively reduced PPD and promoted CAL recovery, providing an evidence-based improvement in efficacy, security, and rational use for clinical drug therapy instruction for periodontitis.
Entrepreneurs' perception: the connection of the brand with the Amazon Forest business
Authors: Diego Luiz , Holanda Francisco Sandro Rodrigues , de Menezes Pedro Vinícius Bertulino , Oliveira Catuxe Varjão de Santana , Villwock Ana Paula Schervinski , de Azevedo Marise Stela Paes 
Published: September 2022

Abstract
The objective of this study was to understand the perception of entrepreneurs based on their business model related to the connection of the Amazon brand. There is a need to present an entrepreneurial perspective on the brand´s changes and their long-term relationships between the Forest and the environmental sustainability on the Brazilian Amazon. The study consisted of semi-structured interviews with 1 out of 7 companies operating in the Amazon region. Brands that develop sustainable businesses in the Brazilian Amazon, with their brand equity based on the region's environmental responsibility, brought an understanding that a full performance of sustainable activities depends on the performance of three agents: entrepreneurs, native peoples and management. Entrepreneurs perceive a greater valuation of their products associated with the sustainability of the Amazon introduced in the brand experience by the customer.
True Self-Healing Polymer-Modified Cement for Ambient-Temperature Applications
Authors: Jian Guoqing , Cosimbescu Lelia , Burton Sarah D. , Rhodes Mark , Varga Tamas , Miller Quin R. S. , fernandez carlos 
Published: September 2022

Abstract
A polymer-modified cement formulation with self-healing capability at ambient temperature is reported. The polymer used is a copolymerization product from the crosslinking reaction between N, N-methylene-bis-acrylamide (MBA) and 1,4-butanediamine (BDA) (MBA-BDA). Results show that the added polymer homogeneously distribute in the cement matrix without phase separation or water segregation. The polymer-modified cement has better workability than conventional cement and self-healing capability as demonstrated by the recovery of compressive strength after multiple damage/healing events. From 13C NMR data a mechanism for self-healing of MBA-BDA-modified cement is proposed based on multiple hydrogen bonding interactions between the oxygen of the carbonyl in the polymer and the hydrogen of the calcium silicate hydrates of cement. Unlike any other polymer-cement technologies reported in the open literature, such as cement modified with superabsorbent polymers or encapsulated polymers where fractures are filled without any apparent chemical bond formation, this self-healing polymer-modified cement represents a true self-healing cement formulation since chemical bonds are formed between the polymer and the surface of a crack restoring the structural integrity of cement as demonstrated by its multiple self-healing capability. To the best of our knowledge, this is the first polymer-modified cement technology with true self-healing capability at ambient temperature.
Thyroid volume is the key predictor of hyperthyroidism remission after RAIT in pediatric patients
Authors: Sheremeta Marina , Korchagina Maria , Trukhin Alexey , Nagaeva Elena , Bezlepkina Olga , Peterkova Valentina 
Published: September 2022

Abstract
Graves' disease (GD) is the leading cause of hyperthyroidism in pediatric patients. Radioiodine therapy (RAIT) is widely used to treat GD, however, the predictors of efficacy of RAIT in childhood and adolescence are still not completely clear. Our purpose was to determine the most significant predictors of efficacy of RAIT in pediatric patients. The study enrolled 144 patients (124 females; 20 males) aged 8 to <18 years old who received the primary dosimetry-guided RAIT for GD. The parameters analyzed included gender, age, thyroid volume according to ultrasound examination before and 12 months after treatment, thyroid stimulating hormone (TSH), free triiodothyronine (FT3) free thyroxine (FT4), TSH receptor antibodies (TRAB) levels at baseline and twelve months after RAIT, 10-20-Min 99mTc thyroid uptake (%), maximum thyroid 131I uptake (%), specific 131I uptake (MBq/g) and therapeutic 131I activity (MBq). Fisher's exact test, Mann-Whitney U-test, Wilcoxon signed–rank test, ROC–analysis and Youden index were used for statistical analysis. Six months after RAIT, hypothyroidism was achieved in 119 (82.6%) patients, euthyroid state was achieved in 6 (4.2%), and hyperthyroidism persisted in 19 (13.2%). Thyroid volume decreased from 17.6 [14.6; 24.1] to 9.25 [7.62; 13.34] mL 12 months after the treatment (p<0.001). The main predictor that showed a statistically significant difference between the groups of patients who achieved and did not achieve remission of GD hyperthyroidism after RAIT was the initial thyroid volume. Using Youden index the optimal cut-off point of the initial thyroid volume in 45.4 ml was determined.Conclusion: The efficacy of the dosimetry-guided RAIT in pediatric patients with GD was 82.6% after 12 months, and one of the major predictors of RAIT success was an initial smaller thyroid volume.
Measuring the ecological performance of China’s National New Areas: A holistic ecological perspective
Authors: Xu Boqian , Lin Zhongjie 
Published: September 2022

Abstract

China’s 19 National New Areas (NNAs) are experiencing an ecological transition toward sustainable development since the mid-2010s. Existing empirical studies are faced with limitations in evaluating the NNAs’ ecological performance and fall short in measuring the NNAs’ impacts on the broader ecosystem. The research engages two approaches, the Ecosystem Service Value (ESV) and the Ecological Footprint (EF), to assess and compare how the NNAs changed local landscape and influenced regional ecosystems. Analyses show that, from 2015 to 2019, 15 NNAs exhibit increasing ESV trends with rates ranging from 0.13 to 122.43 million US dollars per year. In contrast, per capita EF decreased in only 8 of the NNAs’ hinterland cities, and the average rose from 4.22 to 4.26 global hectares. The results suggest that the NNAs have begun to show positive impacts on enhancing the local environment while still having limited influence on the regional ecosystems. This mismatch might result from policy-makers’ and planners’ greenwashing approach to building Eco-cities and the over-concentration of resources in the NNAs caused by top-down political intervention. Through analyzing the NNAs’ ecological performance with the two differing methods, this research advocates for a holistic ecological perspective to embrace sustainable developments across geopolitical boundaries.
Marketing strategies for waste recycling: a bibliometric analysis towards the circular economy
Authors: Aguilar-Morales Shunashi Yectzin , Negrete-Cardoso Mariana , Rosano-Ortega Genoveva , Sánchez-Ruíz Francisco Javier , Sánchez-Baltasar Laura Berenice , Vega-Lebrún Carlos Arturo , Schabes-Retchkiman Pablo Samuel 
Published: September 2022

Abstract

Companies have adopted green marketing and marketing strategies to position themselves in consumer preferences, where the circular economy emerges as a solution to move towards responsible production and consumption patterns. From waste recycling marketing strategies, a descriptive analysis of 120 documents from the SCOPUS database was carried out using bibliometric techniques to know the existing state of the art for the period 1977–2021. The results indicate that the annual scientific production increased in the last ten years by over 200% for 2019, highlighting the United States, China, United Kingdom, Germany and India, and Mexico is in position 22. The conceptual and trend analysis points out the relationship between marketing, waste management, commercialization, recycling, sustainable development, and circular economy, topics that have deepened research in the last 5 years due to the SDGs. Through intellectual analysis, schools of thought were identified, highlighting the authors Chen, Wang, Zhang and Liu, Lu, and White, the most influential and connected with other authors. The results show no link between the study areas, but rather that they are developed in isolation, evidencing an area of ​​opportunity to work on marketing strategies for waste recycling, where companies adopt circular economy objectives, obtaining an advantage. Competitive position and position in the market by offering products from a valorization that the consumer prefers.
Remdesivir improves biomarkers associated with disease severity in COVID-19 patients treated in an outpatient setting
Authors: Pan David , Odorizzi Pamela , Schoenichen Andre , Abdelghany Mazin , Chen Shuguang , Osinusi Anu , Patterson Scott , Downie Bryan , Juneja Kavita , Wallin Jeffrey 
Published: September 2022

Abstract
Remdesivir is an intravenous antiviral with activity against SARS-CoV-2 for treatment of hospitalized COVID-19 patients with moderate-to-severe disease. Recently, remdesivir was evaluated in high-risk, non-hospitalized patients with confirmed SARS-CoV-2 infection and was highly effective at preventing disease progression. Biomarkers associated with clinical outcomes have been identified for COVID-19, but few evaluated in context of antiviral treatment. Here, we assessed baseline biomarkers and the impact of remdesivir treatment on longitudinal biomarker readouts. Six well-known, inflammation-associated biomarkers were elevated at baseline in participants meeting the primary endpoint of hospitalization or death by day 28. Moreover, in comparison to placebo, biomarkers in remdesivir-treated participants showed accelerated improvement, including reduction of soluble angiopoietin-2, D-dimer, and neutrophil-to-lymphocyte ratio, as well as increased lymphocyte counts. These findings have implications for better understanding the activity of antiviral treatments in COVID-19.
Expression Pattern and Clinical Significance of E2F Transcription Factors in Skin Cutaneous Melanoma
Authors: Tan Liuchang , Lu Yuangagn 
Published: September 2022

Abstract
IntroductionE2F is a group of genes that encodes a family of transcription factors in higher eukaryotes. Although emerging evidence indicates that E2Fs are implicated in various cancer types, the diverse expression patterns and prognostic values of E2F transcription factors in SKCM have yet to be elucidated. The purpose of this study was to enhance our knowledge concerning the role of E2Fs in SKCM patients. MethodsGEPIA, The Human Protein Atlas, TIMER, cBioPortal, GeneMANIA, DAVID 6.8 and KEGG PATHWAY Database were utilized in this study.ResultsWe observed a statistically significant increased messenger RNA (mRNA) expression in E2F1/3/5/7 compared with matched normal tissues. A significant correlation was observed between the expression of E2F7/8 and the pathological stage of SKCM patients. In addition, survival analysis revealed that SKCM patients with low transcriptional levels of E2F1/2/3/6 were associated with a significantly better prognosis. Moreover, immune infiltrations analysis showed that transcriptional levels and somatic copy number alterations (SCNA) in E2F family were significantly correlated with several immune cell recruitments, including B cells, CD8+ T cells, CD4+ T cells, neutrophils, macrophages, and dendritic cells. The function of differentially expressed E2Fs and their neighboring genes were mainly linked to P53 signaling pathway, cell cycle, and oocyte meiosis. ConclusionsTaken together, our results may provide novel strategies for the selection of prognostic biomarkers and immunotherapeutic targets in SKCM patients.