bluuebunny/crossref_metadata_2025_split huggingface dataset:
Foreign experience of anti-crisis management of medical institutions
Authors: Shchyrina Katherine , Koshova Svitlana , Parkhomenko-Kutsevil Oksana 
Published: May 2022

The main components of the crisis management system of medical institutions were highlighted. Crisis situations will be understood as the inability of medical institutions to provide the population with medical services on time due to lack of various resources.
As a result of catastrophes, natural disasters, armed conflicts, crisis situations arise when medical institutions are not able to fully provide the population with medical services, there is a lack of funding, human and material resources. Ukraine is no exception, as the armed conflict in the East in 2014 and Russia's full-scale invasion of Ukraine confirmed the lack of sufficient labor, logistical resources and financial support to provide quality medical care to the population. In such conditions, there is a need to develop tools, means of overcoming crisis situations in healthcare facilities.
The aim of the article is to systematize the recommendations for Ukraine on the formation of a system of crisis management of healthcare facilities.
Materials and methods of the research. The basis for the study were provided by private clinics for analysis documents of financial and economic reporting for the pre- and post-crisis periods, as well as scientific works of famous Ukrainian and foreign scientists. The research used methods of analysis, comparison, medical and statistical method and system.
The result of the study was an analysis of the state of funding for healthcare facilities in Ukraine and a comparative analysis with the state of funding for such facilities in other developed countries such as Italy, Germany, Sweden, France.
Conclusions. The main components of the system of anti-crisis management of medical institutions in crisis conditions are: effective leadership, which is provided by managers and management staff; human resources; equal access to basic medicines, vaccines and technologies of guaranteed quality, safety, efficiency; a functioning health information system has been established; financing of healthcare institutions and their financial protection in case of crisis; the process of providing quality, safe and efficient medical services with minimal expenditure of resources. In most European countries, the basic functions of healthcare management (prioritization, financing, service delivery, supply planning, quality control) are decentralized and carried out at the level of regional or local authorities, or regional health insurance funds or trusts
An overview on 1,2,4-triazole and 1,3,4-thiadiazole derivatives as potential anesthesic and anti-inflammatory agents
Authors: Koval Andriy , Lozynskyi Andrii , Shtrygol' Sergiy , Lesyk Roman 
Published: May 2022

The aim. The purpose of this review is to summarize data on the synthesis and structural modification of heterocyclic systems with triazole and thiadiazole fragments in molecules as promising objects in bioorganic and medicinal chemistry.
Materials and methods. The research based on bibliosemantic and analytical methods using bibliographic and abstract databases, as well as databases of chemical compounds.
Results. Modern medicinal chemistry faces many challenges, one of which is the determination of the activity and specificity of therapeutic agents. Recent scientific data showed that triazoles and/or thiadiazoles have broad spectrum of biological activities, in particular antimicrobial, antifungal, antiviral, anticancer and anticonvulsant. Synthetic research allows to propose a whole number of new molecular design directions of biological active triazole and/or thiadiazole derivatives, as well as to obtain directed library that include hundreds of new compounds. This review is an effort to summarize data of its analgesic and anti-inflammatory activity over the last decade. We summarized and analyzed the series of triazole and/or thiadiazole derivatives and provided data of their structure-activity relationship. For optimization and rational design of highly active molecules with optimal «drug-like» characteristics and discovering of possible mechanism of action SAR, QSAR analysis and molecular docking were summarized.
Conclusions. It has been shown that heterocyclic systems containing fragments of triazole and / or thiadiazole are a significant source of promising analgesic and/or anti-inflammatory agents. It has been established that the mentioned heterocyclic derivatives have a high selectivity of action, low toxicity and an effect commensurate with standard drugs
The influence of non-steroidal anti-inflammatory drugs with different mechanisms of action on the course of stress reaction, the functional state of kidneys, liver, and heart on the model of acute general cooling
Authors: Shtrygol’ Sergiy , Koiro Olga , Kudina Olesia , Tovchiga Olga , Yudkevych Tetiana , Oklei Denys 
Published: May 2022

Inhibitors of the arachidonic acid cascade have significant potential as the agents for the prevention of severe cold injuries. The results of the previous studies have demonstrated the pronounced frigoprotective properties of certain non-steroidal anti-inflammatory drugs, primarily diclofenac sodium, etoricoxib, darbufelone mesylate, under the conditions of acute general cooling.
The aim of the study: to investigate the effect of non-steroidal anti-inflammatory drugs with various mechanisms of action on the course of the stress reaction, the functional state of the kidneys, liver, and heart using the model of acute general cooling.
Materials and Methods: The experiment was carried out using 35 outbreed male rats weighing 256±5 g. The studied drugs were administered intragastrically 30 minutes before cold injury modelling: diclofenac sodium at a dose of 7 mg/kg, etoricoxib at a dose of 5 mg/kg, darbufelone mesylate at a dose of 20 mg/kg. Acute general cooling was induced by exposure at –18 °C for 2 hours. The efficacy of the studied drugs was evaluated by the values as follows: the body temperature (measured rectally), the course of a stress reaction according to the criteria of “the stress triad”, the functional state of the kidney and liver according to the changes in the blood serum biochemical parameters, the functional state of the heart according to the electrocardiogram.
Results: It was found that etoricoxib and darbufelone mesylate, and especially diclofenac sodium, demonstrate frigoprotective properties, reducing the severity of hypothermia, have stress-protective activity and a beneficial effect on the functional state of the kidneys. All investigated non-steroidal anti-inflammatory drugs prevent a decrease in myocardial contractility (by the effect on the systolic index) and lengthening of the QT interval caused by acute cold injury. Diclofenac sodium, unlike etoricoxib and darbufelone mesylate, does not enhance the effect of acute general cooling on intraventricular conduction. Under acute exposure to cold, no significant changes in the functional state of the liver were observed, including the groups receiving the nonsteroidal anti-inflammatory medicines.
Conclusions: The prophylactic administration of the arachidonic acid cascade inhibitors, especially the non-selective COX-2 inhibitor diclofenac sodium, reduces the severity of the stress response, contributes to the maintenance of the renal and cardiac function. There are no significant changes in the functional state of the liver under conditions of the experiment
Age dynamics of indicators of the microcirculation system in students according to laser dopler flowmetry
Authors: Gorna Оksana , Horban Daria 
Published: May 2022

The article is devoted to the problem of studying blood microcirculation in healthy individuals at different stages of ontogenesis.
The aim of the study was to investigate the peculiarities of the skin blood flow in students aged 17-21.
Materials and ways of the research. In order to study the functional state of blood microcirculation the method of laser Doppler flowmetry (LDF) was used.
Results. Determination of the age dynamics of the tissue blood flow in subjects aged 17-21 years showed that the parameter of microcirculation in the subjects increased from minimal values at 17 years to maximal values at 21 years. In the female subjects, the value of the microcirculation parameter was higher at 17 years than in the male subjects, while the maximum perfusion value for girls was at 19 years and at 20 years in the male subjects. Assessment of the regulatory devices showed that the amplitude value of low-frequency oscillations in females fell at the age of 19 years and in males at 20 years. The maximal amplitude index of vasomotor oscillations was registered at the age of 19 years both for boys and girls. The amplitude of vasomotor oscillations in the high-frequency range varied in both girls and boys. Three types of LDF-grams were identified among the young adolescents: aperiodic LDF-grams, which correspond to normoemic type of microcirculation, monotonous low amplitude LDF-grams, which correspond to hypooemic type of microcirculation, sinusoidal LDF-grams, which correspond to hyperemic type of microcirculation.
Conclusions. As many studies have shown, the heterochronicity of values of blood microcirculation indices is preserved in male and female subjects: in one age section the indices are higher in females, in the other one – in adolescents. This fact reflects the general biological regularity of different maturation of male and female organisms
Geo-Stratified Analysis of Associations Between Socio-Economic Factors and Diabetes Risk
Authors: Redmond Michelle , Bimali Milan , Ablah Elizabeth , Mayes Paigton , Dugan Katelyn 
Published: May 2022

Introduction. In 2019, diabetes was the seventh leading cause of death in the United States. The association between diabetes risk and socio-economic factors in the United States has been examined primarily at the national level; little is known about this association at the regional level. This study examines and compares the association between diabetes risk and previously established socio-economic factors across four geographic regions (South, Midwest, West, and Northwest).
Methods. We analyzed the 2014 Behavioral Risk Factor Surveillance System (BRFSS) data stratified by four geographic regions of the United States. The risk estimates of diabetes associated with previously established socio-economic factors as well as diabetes prevalence were compared across four geographic regions.
Results. There was marked variation in association between diabetes risk and previously established risk factors across the four geographic regions. In the South, rural residency was associated with increased diabetes risk, whereas in the other geographic regions rural residency had a protective effect. In the South, the diabetes risk for males was 22% higher compared to females in the South, whereas the risk for males was 41% higher than females in the Northeast. Independently, age had the strongest discriminative ability to distinguish between a person with diabetes and a person without diabetes, whereas ethnicity, race and sex had the weakest discriminative abilities.
Conclusions. Our findings suggest a higher prevalence of diabetes by race/ethnicity (Non-Hispanic Black and Hispanic) and income across all four regions. While rural residency is highest in the South, but protective in other regions. Overall, we found age and income provide the highest predictive ability for diabetes risk. This study highlights differences in diabetes prevalence in association between previously established socio-economic variables and diabetes risk across four geographic regions. These findings could help public health professionals and policy makers in understanding the dynamic relationship between diabetes and risk factors at the regional level.
Hybrid Feature Selection based Classifier for Non Functional Requirements
Authors: Dr. Amardeep Gupta Naina Handa, Dr. Anil Sharma, 
Published: May 2022

Feature Selection aims at finding the most relevant features of a problem domain. It is very helpful in improving computational speed and prediction accuracy. However, identification of useful features from hundreds or even thousands of related features is a nontrivial task. In this paper, we introduce a hybrid FS method which combines two FS methods – the filters and the wrappers for NFRs classification. Candidate features are first selected from the original feature set through two filter techniques then the union of these two sets are further refined by more accurate wrappers. This hybrid mechanism takes advantage of both the filters and the wrappers. The mechanism is examined by primary dataset based on NFRs. Experimental results show that better prediction accuracy can be achieved with a smaller feature set.
Otomind: A Text Mining Approach to Automatic Concept Mapping
Authors: Tulasi Appalasamy, Vinesh Thiruchelvam Vinothini Kasinathan, Aida Mustapha, 
Published: May 2022

Despite the linear use of PowerPoint presentation slides in classroom and lecture halls, the brain works primarily with key concepts that it links and integrates. This is a big contrast from the typical student behaviour of reading or memorizing the slides.This paper presents a new system that automatically generate a mind map based on a set of keywords and keyphrases extracted from PowerPoint presentation slides. The system takes a text mining approach and relies on a keyphrase extraction algorithm to extract the keywords and keyphrases. Survey results reflect a rising need of such application as part of educational technologies and the potential benefits are observed and discussed.
Generación de maíces especializados para mejorar la salud y nutrición en México
Authors: Preciado-Ortiz Ricardo Ernesto , Vázquez-Carrillo María Gricelda 
Published: May 2022

Gracias a la gran diversidad genética de maíz existente, a través del tiempo se ha practicado selección hacia maíces con texturas, sabores, aromas y usos específicos. En la actualidad, esta selección sigue siendo vigente tanto por los productores, como por los investigadores quienes aprovechan los avances tecnológicos para asistir la selección de manera eficiente, e identificar maíces con características específicas, por lo que es posible “confeccionar” maíces bio-fortificados, especializados y con calidad de acuerdo a las principales formas de consumo, utilización y aprovechamiento; que aporten mayor valor agregado y que permitan desarrollar componentes bio-activos y alimentos funcionales. Así mismo para la selección de maíces con mayor digestibilidad que impacten y hagan más eficiente la producción pecuaria. La interacción interdisciplinaria de los programas de mejoramiento genético de maíz con grupos de investigación especialistas en disciplinas relacionadas con la tecnología de alimentos, pueden generar maíces especializados y bio-fortificados que contengan compuestos bio-activos, y nutraceuticos. El programa de maíz del INIFAP, en la región del Bajío, en México, ha implementado diversas estrategias para: a) generar maíces mejorados que incrementen la producción y reduzcan costos de cultivo que incrementar la rentabilidad del cultivo en diversas regiones productoras de maíz en México; b) seleccionar maíces bio-fortificados, bio-activos y funcionales con mayor valor agregado, que tengan un impacto en la salud y nutrición de los consumidores, así como un impacto en los sectores pecuario y agroindustrial; c) desarrollar fuentes de germoplasma que contribuyan a reducir riesgos de factores bióticos y abióticos causados por el cambio climático. Con miras a lograr incidir en las estrategias descritas anteriormente, se ha enfatizado en el desarrollo de germoplasma de maíz enfocado a implementar líneas de investigación enfocadas a: generar maíces con alto contenido de aceite; de grano blanco con calidad nixtamalero-tortillera; de grano amarillo; de alta calidad de proteína (QPM); pigmentados; palomeros (Pop Corn); calidad pozolera; calidad para elote; de calidad forrajera; resistentes a fusarium y a la contaminación con Aflatoxinas; entre otras. En el presente manuscrito se presentan los avances y logros obtenidos en estas líneas de investigación. Con base en la información presentada es posible decir que estamos al frente de grandes retos y oportunidades en la investigación interdisciplinaria de maíz en Latinoamérica. Que nos permitirá desarrollar materiales genéticos que además de buscar hacer frente a riegos inminentes de producción, podamos seleccionar maíces diferenciados, bio-fortificados, que aporten mayor valor agregado y que permitan desarrollar componentes bio-activos, alimentos funcionales y desarrollo de nuevos productos.
Influencia de la densidad y de los parámetros de relleno en las propiedades mecánicas compresivas de probetas fabricadas en manufactura aditiva de PLA
Authors: Serrano-Cinchilla Luis , Bustamante-Góez Liliana , Villarraga-Ossa Junes Abdul 
Published: May 2022

La impresión por hilo fundido (FDM, por sus siglas en inglés) tiene una gran cantidad de parámetros que influyen directamente sobre la calidad y las propiedades mecánicas de la pieza final. Actualmente, la manufactura aditiva por FDM ha presentado un gran auge para desarrollos de prótesis por su bajo costo respecto a otros procesos de manufactura; además, esta tecnología es de gran interés para el área de la medicina, dada su capacidad de crear soluciones personalizadas para cada paciente, debido a la variedad de materiales que se pueden emplear, ya que hay una amplia oferta de empresas que fabrican y suministran impresoras y materiales para la impresión. En este trabajo se investigó la influencia de la densidad y de la geometría de los patrones de relleno sobre el esfuerzo máximo, el esfuerzo de fluencia y el módulo de elasticidad a la compresión, en probetas de PLA elaboradas mediante manufactura aditiva con la técnica modelado por FDM. Se emplearon densidades de 10 %, 25 %, 50 %, 75 % y 100 %, y los parámetros de relleno utilizados fueron trihexagonal, subdivisión cúbica y giroide. Todas las probetas se sometieron a ensayos de compresión para calcular sus propiedades mecánicas, y en términos generales se observó que, al aumentar la densidad de relleno, se presenta un aumento en las propiedades a la compresión del material, y la geometría del patrón de relleno puede alterar estas propiedades.
Development of the quadrivalent live attenuated influenza vaccine including two influenza B lineages – Victoria and Yamagata
Authors: Desheva Yu. A. , Smolonogina T. A. , Doroshenko E. M. , Rudenko L. G. 
Published: May 2022

This work is devoted to the research of the live attenuated influenza vaccine (LAIV) comprising two reassortant B/USSR/60/69-based vaccine influenza viruses Victoria and Yamagata. the intranasal immunization of the CBA mice with both victoria and yamagata strains induced 100% lung protection against the subsequent infection with the wild-type influenza B viruses of any antigen lineage. the quadrivalent LAIV (qLAIV) comprising both reassortant influenza B viruses Victoria and Yamagata were safe and areactogenic in adult volunteers. Following qLAIV administration the immune response was achieved to both Victoria and Yamagata lineages.
Vaccine-associated paralytic poliomyelitis in Russian Federation during the period of changes in vaccination schedule (2006-2013 y.y.)
Authors: Ivanova O. E. , Eremeeva T. P. , Morozova N. S. , Shakaryan A. K. , Gmyl A. P. , Yakovenko M. L. , Korotkova E. A. , Chernjavskaja O. P. , Baykova O. Yu. , Silenova O. V. , Krasota A. Yu. , Krasnoproshina L. I. , Mustafina A. N. , Kozlovskaja L. I. 
Published: May 2022

The results of virologic testing of clinical materials and epidemiological analysis of vaccine-associated paralytic poliomyelitis (VAPP) cases obtained in 2006-2013 during AFP surveillance are presented. Among the 2976 cases of AFP 30 cases were vapp. 15 cases were observed in OPV recipients, whereas 15 cases were observed in non-vaccinated contacts. The age of the patients varied from 4 months to 5.5 years (13.6 ± 12.4 months old). Children younger than 1 year constituted 63.3% of the group; boys were dominant (73.3%); 53.3% of children were vaccinated with OPV; the time period between receipt of OPV and onset of palsy was from 2 to 32 days (18.7 ± 8.2). Lower paraparesis was documented in 48.3% of patients; lower monoparesis, in 37.9%; upper monoparesis, in 6.9%; tetraparesis with bulbar syndrome, in 6%. the majority of the patients (85.7%) had an unfavorable premorbid status. The violations of the humoral immunity were found in 73.9% cases: CVID (52.9%), hypogammaglobulinemia (41.2%), selective IgA deficiency (5.9%). In 70.6% cases damage to humoral immunity was combined with poor premorbid status. The most frequently observed (76%, p 0.05) represented the single type of poliovirus – type 2 (44%) and type 3 (32%). All strains were of the vaccine origin, the divergence from the homotypic Sabin strains fell within the region of the gene encoding VP1 protein, which did not exceed 0.5% of nucleotide substitutions except vaccine derived poliovirus type 2 – multiple recombinant (type 2 / type 3 / type 2 / type 1) with the degree of the divergence of 1.44% isolated from 6-month old unvaccinated child (RUS-08063034001). The frequency of the VAPP cases was a total of 1 case per 3.4 million doses of distributed OPV in 2006-2013; 2.2 cases per 1 million of newborns were observed. This frequency decreased after the introduction of the sequential scheme of vaccination (ipv, Opv) in 2008-2013 as compared with the period of exclusive use of OPV in 2006-2007: 1 case per 4.9 million doses, 1.4 cases per 1 million newborns and 1 case per 1.9 million doses, 4.9 cases per 1 million newborns, respectively.
The effect of combination of glycyrrhizic acid with alpha-glutamyl-tryptophan on the experimental adenoviral infection
Authors: Smirnov V. S. , Slita A. V. , Garshinina A. V. , Belyaevskaya S. V. , Anikin A. V. , Zarubaev V. V. 
Published: May 2022

In this work, the activity of glycyrrhizic acid (GL) and dipeptide alpha-glutamyl-tryptophane (EW) as single preparations or in combination (GL+EW) against experimental adenoviral infection in the syrian hamsters was studied. Application of gl and GL+EW was shown to decrease the level of the adenovirus replication in liver tissue by 0.6 – 1.2 lgTCID50 depending on the composition and time point of the post infection. It was also demonstrated that normalization of the structure of the liver tissue was required, which was shown on the level of both optical and electron microscopy. The results obtained in this work suggest that gl and GL+EW may be considered as potential component of the complex therapy of adenoviral infection.
Viral infections and retinoblastoma in children
Authors: Saakyan S. V. , Myakoshina E. V. , Krichevskaya G. I. , Slepova O. S. , Panteleeva O. G. , Andryushin A. E. , Khoroshilova-Maslova I. P. , Zakharova G. P. , Maybogin A. M. 
Published: May 2022

In this work, the results of a comprehensive laboratory examination of 37 children with retinoblastoma were described. The presence of Igm-, IgA, - IgG- antibodies to the herpes simplex virus types 1 and 2, cytomegalovirus (СMV), epstein-Barr virus (eBV), human herpes virus (HHV) type 6, Toxoplasma gondii, mycoplasma hominis and ureaplasma urealyticum in the serum was tested using ELISA. In the polymerase chain reaction the DNA of these pathogens were detected in the blood plasma of 18 patients and tumor biopsy specimens from 10 eyes. The results showed that children with RB were predominantly infected by the herpesviruses, among which prevailed CMV. in 4 of 5 enucleated eyes the DNA of herpesvirus [CMV (2 eyes), EBV (1 eye), HHV 6 (1 eye)] and ureaplasma urealyticum (1 eye) were also present in tumor tissue. Nucleic acid of infectious microorganisms were considerably more often detected in the tumor tissue than in plasma (5 of 10, 1 of 18, respectively; p = 0.023), suggesting thereby the presence of the virus in the eye and its adverse role in the pathogenesis of the RB.