bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENINGKATAN EKONOMI ANGGOTA KOMUNITAS USAHA KOPERASI CREDIT UNION HATI AMBOINA MELALUI PENDIDIKAN DAN PELATIHAN LITERASI KEUANGAN DAN PEMBUKUAN
Authors: Esomar Maria , Arifin Hasmia Melati 
Published: March 2022

Maluku province has a financial literacy rate of 36.48%, still below the national index. (OJK, 2019). Cooperatives are expected to have an important role in assisting the government in terms of financial inclusion and literacy. The challenges and problems faced by partners are bad credit problems. Bad loans are caused, among others, due to the lack of understanding and ability of members in managing personal and business finances. The purpose of this activity can help members to have financial plans, plan future expenses, and have savings and also be able to manage their business finances. The procedure for this empowerment activity includes: 1) Coordination with partners regarding the preparation of activity schedules; 2) Preparation of training and material development; 3) Counseling on financial literacy and business bookkeeping; 4) Training on the use of financial instruments and excel applications for business bookkeeping; 5) Assistance and evaluation of the activities carried out. The results obtained are increased understanding of business group community members about financial literacy and bookkeeping, members are able to fill in monthly budget instruments and are able to understand simple bookkeeping and the management of the CU Hati Amboina Cooperative able to use excel bookkeeping applications for further socialization to members of other business groups.
Provinsi Maluku memiliki tingkat literasi keuangan 36,48% masih dibawah indeks nasional. (OJK, 2019). Koperasi diharapkan memiliki peran penting dalam membantu pemerintah dari sisi inklusi dan literasi keuangan. Tantangan dan permasalahan yang dihadapi mitra yaitu masalah kredit macet. Kredit macet diakibatkan antara lain karena kurangnya pemahaman dan kemampuan anggota dalam mengelola keuangan pribadi dan usaha. Tujuan kegiatan ini dapat membantu anggota untuk mempunyai rencana keuangan, merencanakan pengeluaran masa depan, dan memiliki tabungan dan juga mampu menata keuangan usaha mereka, Prosedur kegiatan pemberdayaan ini meliputi: 1) Koordinasi dengan mitra terkait penyusunan jadwal kegiatan; 2) Persiapan pelatihan dan pengembangan materi; 3) Penyuluhan tentang literasi keuangan dan pembukuan usaha; 4) Pelatihan penggunaan instrumen keuangan dan aplikasi excel untuk pembukuan usaha; 5) Pendampingan dan evaluasi terhadap kegiatan yang dilaksanakan. Hasil yang diperoleh yaitu meningkatnya pemahaman anggota komunitas kelompok usaha tentang literasi keuangan dan pembukuan, anggota mampu mengisi instrumen anggaran belanja bulanan dan mampu memahami pembukuan sederhana dan manajemen Koperasi CU Hati Amboina mampu menggunakan aplikasi pembukuan excel untuk seterusnya disosialisasikan kepada anggota kelompok usaha yang lain.
BIDIK LAHAN SEMPIT DESA CILEBUT JADI INDAH PRODUKTIF MELALUI PEMANFAATAN TEKNOLOGI VERTIKULTUR HIDROPONIK
Authors: Sara Dem Vi , Rusyana Enang , Rubyasih Arina , Wijayanti Sukma Wahyu 
Published: March 2022

Lahan pertanian terutama di wilayah perkotaan dan pinggiran kota, saat ini banyak yang beralih fungsi menjadi daerah pemukiman. Desa Cilebut Barat yang berada di pinggiran kota Bogor Kabupaten Bogor pun tak luput dari imbas pesat dan masifnya urbanisasi. Wilayah ini mengalami alih fungsi lahan yang tak terbendung dari degradasi lahan pertanian menjadi pemukiman. Daerah perumahan yang dibangun, dipaksakan untuk menampung lonjakan pendatang, sehingga area terbuka untuk luasan tanaman dan serapan air hujan semakin sempit. Betonisasi jalan komplek menyebabkan desa Cilebut Barat sering mengalami banjir saat musim hujan dan kekeringan saat musim kemarau. Suasana lingkungan perumahan terkesan gersang dan tidak segar karena sangat kurangnya area penghijauan. Data desa menunjukkan bahwa sebagian besar warga desa adalah pensiunan pegawai, ibu rumah tangga, dan profesi lepas lain yang masih kesulitan memenuhi kebutuhan primer hidupnya. Mereka sangat mengidamkan lingkungan yang asri dan produktif, tetapi terkendala dengan pengetahuan, biaya dan lahan yang sempit terbatas. Tim Pengabdian kepada Masyarakat (PkM) Universitas Terbuka Bogor tertantang untuk membantu memberi alternatif solusi menciptakan lingkungan yang asri, sekaligus mengembangkan kegiatan berestetika, sehat, dan produktif. Program yang ditawarkan adalah edukasi, pendampingan pelatihan, dan praktik memanfaatkan teknologi vertikultur hidroponik pada lahan sempit pekarangan. Vertikultur hidroponik adalah sistem tanam dengan media air di dalam wadah/paralon yang disusun/dirakit secara vertikal atau bertingkat pada lahan terbatas. Tanaman yang direkomendasikan adalah tanaman pangan sayuran karena dapat dijadikan sebagai bagian dari gaya hidup (life style) dalam memenuhi kebutuhan pangan keluarga. Kegiatan dilaksanakan di lingkungan RT 07/RW 09 pada bulan September-Oktober 2020 dengan peserta sejumlah 48 orang warga desa. Kebermanfaatan program terlihat dari peningkatan pengetahuan, keterampilan, aktivitas sosial kebersamaan warga desa dalam menciptakan lingkungan hijau, indah, kreatif yang berpotensi menopang kehidupan ekonomi sehari-hari.
Impact of Preanalytical and Analytical Methods on Cell-Free DNA Diagnostics
Authors: Krasic Jure , Abramovic Irena , Vrtaric Alen , Nikolac Gabaj Nora , Kralik-Oguic Sasa , Katusic Bojanac Ana , Jezek Davor , Sincic Nino 
Published: March 2022

Graphical AbstractDepiction of the experimental design.
Comparative Safety and Efficacy of Eight Antithrombotic Regimens for Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention
Authors: Liang Bo , Zhu Yong-Chun , Gu Ning 
Published: March 2022

BackgroundAntithrombotic therapy for patients with atrial fibrillation undergoing percutaneous coronary intervention is facing major treatment problems in clinical practice.MethodsWe firstly conducted a Bayesian network meta-analysis to study the safety and efficacy of different antithrombotic regimens. Only randomized controlled trials from PubMed, Web of Science, Cochrane Central Register of Controlled Trials, Embase, and China National Knowledge Infrastructure were included in our study. The Bayesian random-effects model was used in this study. The primary safety and efficacy outcomes were major bleeding according to the criteria of Thrombolysis In Myocardial Infarction (TIMI) and trial-defined major adverse cardiovascular events, respectively. The secondary safety outcomes were combined TIMI major and minor bleeding, trial-defined primary bleeding events, and intracranial hemorrhage. The secondary efficacy outcomes were all-cause or cardiovascular mortality, myocardial infarction, stroke, stent thrombosis, and hospitalization.ResultsTotal of 11,532 patients from the five randomized controlled trials were analyzed, of whom 8,426 were male. Compared with vitamin K antagonist (VKA) plus P2Y12 inhibitor, the odds ratios (95% credible intervals) for TIMI major bleeding were 1.70 (0.77–3.80) for VKA plus dual antiplatelet therapy (DAPT), 1.20 (0.30–4.60) for rivaroxaban plus P2Y12 inhibitor, 1.00 (0.25–3.90) for rivaroxaban plus DAPT, 0.76 (0.21–2.80) for dabigatran plus P2Y12 inhibitor, 0.71 (0.25–2.10) for apixaban plus P2Y12 inhibitor, 1.40 (0.52–3.80) for apixaban plus DAPT, and 1.00 (0.27–4.00) for edoxaban plus P2Y12 inhibitor. For trial-defined major adverse cardiovascular events, compared with VKA plus P2Y12 inhibitor, the odds ratios (95% credible intervals) were 1.10 (0.61–2.00) for VKA plus DAPT, 1.20 (0.45–3.70) for rivaroxaban plus P2Y12 inhibitor, 1.10 (0.38–3.20) for rivaroxaban plus DAPT, 1.10 (0.43–3.10) for dabigatran plus P2Y12 inhibitor, 1.00 (0.47–2.20) for apixaban plus P2Y12 inhibitor, 0.99 (0.46–2.20) for apixaban plus DAPT, and 1.20 (0.43–3.40) for edoxaban plus P2Y12 inhibitor. Apixaban plus P2Y12 inhibitor was the highest-ranking of safety outcomes and VKA plus P2Y12 inhibitor was the highest-ranking of efficacy outcomes other than trial-defined major adverse cardiovascular events.ConclusionApixaban plus P2Y12 inhibitor seems to be linked with fewer bleeding complications while retaining antithrombotic efficacy. Moreover, for most efficacy indicators, the ranking of VKA plus P2Y12 inhibitor is still very high.Systematic Review Registration[www.crd.york.ac.uk/prospero/], identifier [CRD42020149894].
MDN1 Mutation Is Associated With High Tumor Mutation Burden and Unfavorable Prognosis in Breast Cancer
Authors: Hao Shuai , Huang Miao , Xu Xiaofan , Wang Xulin , Huo Liqun , Wang Lu , Gu Jun 
Published: March 2022

Background: Breast cancer (BRCA) is the most common cancer worldwide and a serious threat to human health. MDN1 mutations have been observed in several cancers. However, the associations of MDN1 mutation with tumor mutation burden (TMB) and prognosis of BRCA have not been investigated.Methods: Genomic, transcriptomic, and clinical data of 973 patients with BRCA from The Cancer Genome Atlas (TCGA) database were analyzed. The clinical attributes of BRCA based on the MDN1 mutation status were assessed by comparing TMB and tumor infiltrating immune cells. Gene ontology analysis and gene set enrichment analysis (GSEA) were conducted to identify the key signaling pathways associated with MDN1 mutation. Moreover, univariate and multivariate Cox regression analyses were performed to assess the association between prognostic factors and survival outcomes. Finally, nomograms were used to determine the predictive value of MDN1 mutation on clinical outcomes in patients with BRCA.Results: MDN1 was found to have a relatively high mutation rate (2.77%). Compared to the MDN1 wild-type patients, the TMB value was significantly higher in MDN1 mutant patients (p &lt; 0.001). Prognostic analysis revealed that MDN1 mutant patients had a worse survival probability than MDN1 wild-type patients (hazard ratio = 2.91; 95% CI:1.07–7.92; p = 0.036). GSEA revealed samples with MDN1 mutation enriched in retinol metabolism, drug metabolism cytochrome P450, glucuronidation, miscellaneous transport, and binding event pathways.Conclusion: MDN1 mutation was found to be associated with high TMB and inferior prognosis, suggesting that MDN1 mutation may play a potential role in prognosis prediction and immunotherapy guidance in BRCA.
Deep Brain Stimulation Modulates Multiple Abnormal Resting-State Network Connectivity in Patients With Parkinson’s Disease
Authors: Bai Yutong , Diao Yu , Gan Lu , Zhuo Zhizheng , Yin Zixiao , Hu Tianqi , Cheng Dan , Xie Hutao , Wu Delong , Fan Houyou , Zhang Quan , Duan Yunyun , Meng Fangang , Liu Yaou , Jiang Yin , Zhang Jianguo 
Published: March 2022

BackgroundDeep brain stimulation (DBS) improves motor and non-motor symptoms in patients with Parkinson’s disease (PD). Researchers mainly investigated the motor networks to reveal DBS mechanisms, with few studies extending to other networks. This study aimed to investigate multi-network modulation patterns using DBS in patients with PD.MethodsTwenty-four patients with PD underwent 1.5 T functional MRI (fMRI) scans in both DBS-on and DBS-off states, with twenty-seven age-matched healthy controls (HCs). Default mode, sensorimotor, salience, and left and right frontoparietal networks were identified by using the independent component analysis. Power spectra and functional connectivity of these networks were calculated. In addition, multiregional connectivity was established from 15 selected regions extracted from the abovementioned networks. Comparisons were made among groups. Finally, correlation analyses were performed between the connectivity changes and symptom improvements.ResultsCompared with HCs, PD-off showed abnormal power spectra and functional connectivity both within and among these networks. Some of the abovementioned abnormalities could be corrected by DBS, including increasing the power spectra in the sensorimotor network and modulating the parts of the ipsilateral functional connectivity in different regions centered in the frontoparietal network. Moreover, the DBS-induced functional connectivity changes were correlated with motor and depression improvements in patients with PD.ConclusionDBS modulated the abnormalities in multi-networks. The functional connectivity alterations were associated with motor and psychiatric improvements in PD. This study lays the foundation for large-scale brain network research on multi-network DBS modulation.
Association of Haptoglobin Phenotype With Neurological and Cognitive Outcomes in Patients With Subarachnoid Hemorrhage
Authors: Han Sung Woo , Kim Bong Jun , Kim Tae Yeon , Lim Seung Hyuk , Youn Dong Hyuk , Hong Eun Pyo , Rhim Jong Kook , Park Jeong Jin , Lee Jae Jun , Cho Yong Jun , Gaastra Ben , Galea Ian , Jeon Jin Pyeong 
Published: March 2022

BackgroundTo assess the association of haptoglobin (Hp) phenotype with neurological and cognitive outcomes in a large cohort of patients with subarachnoid hemorrhage (SAH).MethodsThis prospective multicenter study enrolled patients with aneurysmal SAH between May 2015 and September 2020. The Hp phenotype was confirmed via Western blots. The relative intensities of α1 in individuals carrying Hp2-1 were compared with those of albumin. Multivariable logistic and Cox proportional-hazard regression analyses were used to identify the risk factors for 6-month and long-term outcomes, respectively.ResultsA total of 336 patients including the phenotypes Hp1-1 (n = 31, 9.2%), Hp2-1 (n = 126, 37.5%), and Hp2-2 (n = 179, 53.3%) were analyzed. The Hp phenotype was closely associated with 6-month outcome (p = 0.001) and cognitive function (p = 0.013), and long-term outcome (p = 0.002) and cognitive function (p &lt; 0.001). Compared with Hp1-1 as the reference value, Hp2-2 significantly increased the risk of 6-month poor outcome (OR: 7.868, 95% CI: 1.764–35.093) and cognitive impairment (OR: 8.056, 95% CI: 1.020–63.616), and long-term poor outcome (HR: 5.802, 95% CI: 1.795–18.754) and cognitive impairment (HR: 7.434, 95% CI: 2.264–24.409). Long-term cognitive impairment based on the Hp phenotype was significantly higher in patients under 65 years of age (p &lt; 0.001) and female gender (p &lt; 0.001). A lower relative α1/albumin intensity (OR: 0.010, 95% CI: 0.000–0.522) was associated with poor outcome at 6 months but not cognitive impairment in patients with SAH expressing Hp2-1.ConclusionHp2-2 increased the risk of poor neurological outcomes and cognitive impairment compared with Hp1-1. For Hp2-1, higher relative α1 intensities were related to 6-month favorable outcomes.
Medication-Related Readmissions: Documentation of the Medication Involved and Communication in the Care Continuum
Authors: Lee Ze-Yun , Uitvlugt Elien B. , Karapinar-Çarkit Fatma 
Published: March 2022

Background: Of all readmissions, 21% are medication-related readmissions (MRRs). However, it is unknown whether MRRs are recognized at the time of readmission and are communicated in the care continuum.Objectives: To identify the prevalence of MRRs that contain a documentation on the medication involved (and therefore are regarded as recognized), and the proportion of communicated MRRs.Setting: The study was performed in a teaching hospital.Methods: In a previous study, a multidisciplinary team of physicians and pharmacists assessed the medication-relatedness, the medication involved and preventability of unplanned readmissions from seven departments. In the current cross-sectional study, two pharmacy team members evaluated the patient records independently. An MRR was regarded as recognized when the medication involved was documented in patient records. An MRR was regarded as communicated to the patient and/or the next healthcare provider when the medication involved or a description was mentioned in discharge letters or discharge prescriptions. The relationship between documented MRRs and whether the MRR was preventable as well as the relationship between (un)documented MRRs and the length of stay (LOS) were assessed. Descriptive data analysis was used.Results: Of 181 included MRRs, 72 (40%) were deemed preventable by the multidisciplinary team. For 159 of 181 MRRs (88%), a documentation on the medication involved was present. Of 159 documented MRRs, 93 (58%) were communicated to patients and/or caregivers, 137 (86%) to the general practitioner, and 4 (3%) to the community pharmacy. The medication involved was documented less often for potentially preventable MRRs than for non-preventable MRRs (78 vs. 95%; p = 0.002). The LOS was longer for MRRs where the medication involved was undocumented (median 8 vs. 5 days; p = 0.062).Conclusion: The results of this study imply that MRRs are not always recognized, which could impact patients’ well-being. In this study an increased LOS was observed with unrecognized MRRs. Communication of MRRs to the patients and/or the next healthcare providers should be improved.
What Has Changed in the Behaviors of the Public After the COVID-19 Pandemic? A Cross-Sectional Study From the Saudi Community Perspective
Authors: Wajid Syed , Samreen Sana , Sales Ibrahim , Bawazeer Ghada , Mahmoud Mansour Adam , Aljohani Majidah A. 
Published: March 2022

BackgroundCoronavirus disease-2019 (COVID-19) is caused by severe acute respiratory syndrome-coronavirus (SARS-CoV) and represents a major public health threat that aggressively promotes increased morbidity and mortality. Changes in public behavior were more common during the pandemic to protect against the infection. Suboptimal behavioral practices for a specific disease would increase the susceptibility of the public to infection. This study aimed to determine changes in behaviors of the general public during the COVID-19 pandemic.MethodsA cross-sectional study was conducted using an online questionnaire survey to determine the extent of public behavioral changes in Saudi Arabia during the COVID-19 pandemic. Data were collected with a self-reported survey, and analysis was conducted using Statistical Package for the Social Sciences version 26 (SPSS). A chi-square test was performed to determine the association among variables. A P ≤ 0.05 was considered statistically significant.ResultsOf 348 respondents, 244 (70.1%) were male, and 270 (77.6%) had a university degree. Approximately 48% used social media to seek COVID-19 information, and 36% (n = 124) avoided large gatherings. Approximately one-fourth of the respondents always avoided public transportation, while 65.8% reported avoiding traveling to infected areas. Of the participants, 33% always washed their hands, while 36% always used an alcohol-based sanitizer. There was a significant association between age group and employment status with respect to hand washing frequency (p &lt; 0.05). There was also a significant association between age group (p &lt; 0.0001) and employment status and wearing of face masks (p &lt; 0.048).ConclusionThis study highlights changes in the public's behaviors in Saudi Arabia during the COVID-19 pandemic for protection against the infection and reports acceptable preventative practices against COVID-19 in the Saudi community. Furthermore, continuous awareness of recommended protective measures for COVID-19 is still warranted.
Case Report: A Case of Gallbladder Carcinosarcoma With Osteoclast-like Multinucleated Giant Cells that Was Associated With RANK‐RANKL Signaling
Authors: Niwa Ayumi , Tomita Hiroyuki , Watanabe Naoki , Kiriyama Shunya , Hara Akira , Tanaka Takuji 
Published: March 2022

Introduction: Gallbladder carcinosarcoma with osteoclast-like multinucleated giant cells is known to be most uncommon form of gallbladder cancer. Owing to its rarity, the pathogenesis of gallbladder carcinosarcoma with osteoclast-like multinucleated giant cells is largely unknown.Case Presentation: We present a case of carcinosarcoma with osteoclast-like multinucleated giant cells in the gallbladder. A 57-year-old woman visited our hospital due to jaundice. An examination revealed calculous cholecystitis and gallbladder carcinoma. After cholecystectomy, macroscopic examination disclosed one whitish mass and another distinct brown and pendulous mass in the body of the gallbladder. A pathological examination revealed that each mass had a different histological type: adenosquamous carcinoma and carcinosarcoma with osteoclast-like multinucleated giant cells. Immunohistochemistry revealed that these osteoclast-like multinucleated giant cells are CD68(+), CD163(−), and MIB-1(−). In addition, the osteoclast-like multinucleated giant cells showed the strong expression of RANK and sarcoma cells around the osteoclast-like multinucleated giant cells, were positive for RANKL. Furthermore, RUNX2 was positive for some sarcoma cells. The result indicated that osteoclastic and osteoblast-like differentiation occurred in our case.Conclusion: To our knowledge, this is the first case to show the interaction of RANK-RANKL signaling in gallbladder carcinosarcoma with osteoclast-like multinucleated giant cells.
Economic and Environmental Assessment Using Two Renewable Sources of Energy to Produce Heat and Power for Industrial Applications
Authors: Martínez-Rodríguez Guillermo , Baltazar Juan-Carlos , Fuentes-Silva Amanda L. , García-Gutiérrez Rafael 
Published: March 2022

Economic criteria have prevailed in studies on integration of renewable energies. Tons of dangerous emissions are emitted by a biomass fuel, causing negative impacts over atmosphere and health. Current research proposes Pinch Analysis of solar thermal energy and the joint use of biomass (sugarcane bagasse) to produce heat and power in a Caribbean sugar mill; measuring emissions like: carbon oxide CO, carbon dioxide CO2, dinitrogen monoxide N2O, nitrogen oxides NOx, sulfur oxides SOx, non-methane volatile organic compounds NMVOC, methane CH4, and particulate matters, to have a global and clear view of the impacts of biomass as a renewable fuel. Variables like kWh cost, the installation and device area of renewable energy, and greenhouse gas emissions, are analysed to assess the effect on the integration final design, the target of which is to control the use of biomass. It is possible to produce an economically competitive integration design of solar system LCOEth solar = 0.0636 USD/kWh, LCOEele = 0.1392 USD/kWh), zero greenhouse gases emissions (ΔTminrew=7 °C), and deletion of 378,711.53 t/year of CO2 and 9567.56 t/year of solid particles. There are many possibilities that can implemented; in one of them, bagasse burning is reduced by 30% and the solar collector network for required power production is reduced by 68%.