bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychoacoustic Characteristics of Different Brake Creep Groan Classes and their Subjective Noise Annoyance in Vehicle and Half-Axle Tests
Authors: Huemer-Kals Severin , Tóth Máté , Prezelj Jurij , Zacharczuk Martin , Fischer Peter , Häsler Karl 
Published: October 2022

Abstract
Brake creep groan is a severely annoying noise and vibration phenomenon. Especially on the Asian market, customer feedback about creep groan is common, indicating creep groan’s impact towards the quality impression of a car. Hence, treatment of these stick-slip related creep groan phenomena is necessary. As numerous design conflicts exist for brake and axle, a complete mitigation of the phenomenon is often not possible. A reduction of creep groan’s annoyance by changing the noise’s level and characteristics is therefore typically aspired. One approach towards this goal could include the usage of psychoacoustics: This work deals with psychoacoustic characteristics of different creep groan classes. Low-frequency groan, high-frequency groan and transition groan classes are compared regarding loudness, sharpness, roughness, fluctuation strength and tonality. Standard statistic methods as well as machine learning approaches are applied on signals from vehicle tests and half-axle tests. Test results depict the different characteristics of each creep groan class. By mapping the results to the subjective rating of trained test drivers, the annoyance of different classes is compared. Low-frequency groan, dominated by longitudinal axle vibrations, is found to be least annoying. This low annoyance is best depicted by the psychoacoustic parameters loudness and roughness. Presented results allow an optimization of brake system design to reduce creep groan’s annoyance, leading to higher customer satisfaction and a more goal-oriented treatment of this NVH problem.
Cognitive-adaptive functioning gap and mediating factors impact on adaptive functioning in preschool-aged children with autism spectrum disorder: a retrospective study
Authors: Wang Shi-huan , Zhou Qing , Chen Kai-yun , Ceng Chao-qun , Zhan Guo-dong , You Cong , Xing Yu , Zou Yuan-yuan , Deng Hong-zhu 
Published: October 2022

Abstract
Background Few studies have focused on cognitive-adaptive functioning gap in autism spectrum disorder (ASD), and how mediating factors impact on adaptive functioning remains undefined. This study aims to investigate the gap between cognitive functioning and adaptive functioning in preschool-aged children with ASD, especially in verbal and non-verbal intelligence quotient (IQ) level. Mediating factors of cognitive functioning, ASD severity, early development and socioeconomic factors are systematically explored to determine adaptive functioning.
Methods A total of 151 children with ASD were enrolled, aged 2.5-6 years. Adaptive Behavior Assessment System Version II (ABAS-II)，Wechsler Preschool and Primary Scale-IV (WPPSI-IV), Autism Diagnostic Observation Schedule (ADOS) were respectively performed to assess adaptive functioning, cognitive functioning and ASD severity. All children were divided into two groups based on IQ: IQ≥70 group and IQ<70 group. The difference of IQ-adaptive skills gap between the two groups were explored by calibrating age, age of diagnosis and IQ. Verbal acceptation index (VAI) and nonverbal index (NVI) were distinguished to predict adaptive skills.
Results The gap between IQ and adaptive skills was significant in ASD with IQ≥70, and the differences in VIA and NVI were still statistically significant (all P<0.001). VIA was positively association with overall adaptive skills and specific domain, whereas NVI had no significant correlations with adaptive skills. Despite ADOS-Calibrated severity scores were negatively correlated with social and practical skills, the scores accounted for no significant variance. Age of first walking unaided was positively correlation with adaptive skills and specific domain (all P<0.05).
Conclusions The IQ-adaptive functioning gap is significant in ASD with IQ≥70, suggesting that "high functioning autism" is not an appropriate description merely on account of IQ. Verbal IQ is a specific factor to predict adaptive functioning of ASD; The severity of ASD symptoms have no significant contribution to predict adaptive functioning; Early signs of motor development may be a predictor to adaptive functioning in preschool-aged children with ASD.
Determination of Temperature Rise and Heating Rate of Curing Modes of Two Different Dental Light-Curing Units: The Importance of Heating Rate
Authors: Soori Ahmad , Soori Faezeh , Kowsary Farshad , Kasraei Shahin 
Published: October 2022

Abstract
The heat generated in the process of light-curing may cause irreversible damage to the dental pulp. This study aimed to assess heat transfer in the process of irradiation of a dentin disc by using different modes of quartz-tungsten halogen (QTH) and light-emitting diode (LED) dental curing units. The surface temperature was measured by an infrared (IR) thermometer following light-curing with standard, ramp, boost, and bleaching modes of a QTH curing unit, and high, soft and pulse modes of a LED curing unit. Since the maximum temperature rise alone is not sufficient to study the thermal damage to the pulp tissue, we also assessed the temperature rise profile and heating rate, in addition to the maximum temperature rise in this study. The results showed that decreasing the duration of light-curing effectively decreased the risk of pulpal damage. Shorter radiation modes such as the 10 s standard mode, and the 10 s boost curing mode of the QTH curing unit and the 5 s high mode, and the 10 s pulse mode of the LED curing unit all had the lowest risk of thermal damage to the pulp.
Incidence of Fungal Infections Including Mucormycosis in Respiratory Intensive Care
Authors: El-Koa Amal A. , El-Kalashy Mai M. , Awad Samah M. , Torayah Mohammad M. , Tawadros Beshoy B. 
Published: October 2022

Abstract
Background
Recent improvements in the use of wide-spectrum antibiotics for the treatment of life-threatening illnesses have led to an upsurge in fungus infections in critical care units. An invasive fungal illness called Mucormycosis is becoming more common among seriously unwell individuals. Due to its strong invasive power and inherently low susceptibility to antifungal treatments, its prognosis is bleak. Our study aimed to determine the incidence of fungi, especially Mucormycosis, in respiratory intensive care units.
Methods
Patients hospitalized at Menoufia University Hospitals' general and respiratory intensive care units between June 2021 and June 2022 were included in this study. On Sabouraud dextrose agars, bronchial secretions were cultured and evaluated for fungus susceptibility.
Results
Regarding mechanical ventilation and APACHE II score, there was a substantial difference between fungus growth and absence of fungus growth. Regarding Fate, the presence of bilateral lung consolidation associated with cavitations on CT chest, and APACHE II score, there was a significant difference between negative and positive Mucormycosis development. The most susceptible antifungal agent was Caspofungin.
Conclusion
In patients in the pulmonary intensive care unit (ICU) who have a high resistance rate, fungus infections are a big issue. The danger of a fungal infection rises with mechanical ventilation. For quick treatment, isolating and diagnosing the fungus is essential.
Determination of Zinc Sufficiency via the Direct Assessment of Fingertip Blood Samples
Authors: Miyajima Yuka , Nodera Makoto , Adachi Shuichi 
Published: October 2022

Abstract
Zinc (Zn) sufficiency status is commonly determined clinically by serum or plasma zinc concentrations from venous blood collection. To investigate whether the measurement of whole blood Zn concentration using simple and less invasive fingertip blood samples reflects the Zn sufficiency in the body, we first measured the tissue and whole blood Zn concentrations during Zn deficiency and recovery in rats, followed by the same measurements in the fingertip blood samples of young females. Ten microliter of blood sample was diluted, hemolyzed in ultrapure water, and analyzed (50 samples/2 h) without acid digestion or any other pretreatment. Zn restriction in young rats rapidly resulted in Zn deficiency symptoms and a marked decrease in serum Zn concentrations; however, there were no significant changes in Zn concentrations in the liver, muscle tissue, or whole blood from the rat tail vein. In young Japanese women with no health problems (N = 69), average fingertip blood Zn concentration was 793.5 µg/dL (95% confidence interval [C.I.]: 717.0–870.1 µg/dL) and average serum Zn concentration was 76.4 µg/dL (95% C.I.: 78.7–74.2 µg/dL), although no correlation was observed between the two. Average estimated Zn concentration in blood cells was 1271.6 µg/dL (95% C.I.: 1144.0–1399.1 µg/dL), suggesting that individual differences were predominantly influenced by the Zn concentration in blood cells. Whole-blood Zn concentration assay using small amounts of fingertip blood is feasible as a simple evaluation method. Further study will be conducted in all age groups, including males, and the association with variables will be analyzed.
Machine Learning for Power Transformer Sfra Based Fault Detection
Authors: Bjelić Miloš , Brković Bogdan , Žarković Mileta , Miljković Tatjana 
Published: October 2022

Abstract
This paper presents machine learning methods for health assessment of power transformer based on sweep frequency response analysis. The paper presents an overview of monitoring and diagnostics based on statistical Sweep Frequency Response Analysis (SFRA) based indicators that are used to evaluate the state of the power transformer. Experimental data obtained from power transformers with internal short-circuit faults is used as a database for applying machine learning. Machine learning is implemented to achieve more precise asset management and condition-based maintenance. Unsupervised machine learning was applied through the k-means cluster method for classifying and dividing the examined power transformer state into groups with similar state and probability of failure. Artificial neural network (ANN) and Adaptive Neuro Fuzzy Inference System (ANFIS) as part of supervised machine learning are created in order to detect fault severity in tested power transformers of different lifetime. The presented machine learning methods can be used to improve health assessment of power transformers.
Kidney Stone Trends in Israel – The Relationship Between Patients’ Stone Type and Demographics – 10K Patients Analysis
Authors: Zreik Rani , Solomon Ilona Pilosov , Saliba Walid , Tor Ruth , Cohen Sharon , Friefeld Yuval , Dekel Yoram , Klein Ilan 
Published: October 2022

Abstract
Objectives
To analyze urinary stone composition in Israel and determine the effects of demographic parameters, such as gender, age, socioeconomic status, ethnicity, medical history and geographic region, on stone composition.
Patients and Methods
The stone composition of 10633 consecutive patients from an Israeli database was analyzed between 2014 and 2019 by a central laboratory using the Fouriertransform infrared spectroscopy. Chi-squared test was used to determine associations between stone composition and the different demographic parameters.
Results
Calcium oxalate (CaOx) monohydrate was the predominant stone type (51.9%).
5776 stones had pure component (54%) and 4,857 (46%) had mixed components. Men had a higher frequency of CaOx stones (89.6% vs. 85.6%), whereas women had a higher frequency of calcium phosphate, infection, and cystine stones (27.2%, 17.7%, and 0.9% vs. 17.2%, 7.5%, and 0.5%, respectively). Cystine stones were more abundant in Arabs (1.2% vs. 0.5% in the Jewish population). Lower socioeconomic status was associated with higher prevalence of calcium phosphate, uric acid, and infectious stones and a lower prevalence of CaOx stones. Uric acid stones were associated with medical conditions, such as diabetes, hypertension, ischemic heart disease, and obesity (28.3%, 24.9%, 25.7%, and 22.6% vs. 9.6%, 8.4%, 12.3%, and 10.3%, respectively).
Conclusions
The most common stone type was CaOx monohydrate. Stone types are highly influenced by patients’ demographics.
Preoperative and intraoperative assessment of myometrial invasion in in patients with non-endometrioid endometrial carcinoma—a large-scale, multi-center and retrospective study
Authors: Yang Xiaohang , Yin Jingjing , Fu Yu , Shen Yuanming , Zhang Chuyao , Yao Shuzhong , Xu Congjian , Xia Min , Lou Ge , Liu Jihong , Lin Bei , Wang Jianliu , Zhao Weidong , Zhang Jieqing , Cheng Wenjun , Guo Hongyan , Guo Ruixia , Xue Fengxia , Wang Xipeng , Han Lili , Li Xiaomao , Zhang Ping , Zhao Jianguo , Li Wenting , Dou Yingyu , Wang Zizhuo , Liu Jingbo , Li Kezhen , Chen Gang , Sun Chaoyang , Sun Pengming , Lu Weiguo , Yao Qin 
Published: October 2022

Abstract
Introduction: Myometrial invasion (≤/＞50%) is a prognostic factor for lymph node metastases and decreased survival in non-endometrioid endometrial carcinoma. Our aim was to explore the mode of myometrial invasion diagnosis in FIGO stage I non- endometrioid carcinoma and to evaluate differences of diagnostic efficiency among intraoperative frozen section, gross examination, MRI and CT in clinical practice and to suggest which one should be routinely performed.
Method: This is a historical cohort study nationwide (thirty centers in China between January 2000 and December 2019). Clinical data including age, histology, method of myometrial invasion evaluation (MRI, CT, intraoperative gross examination, frozen section) and final diagnosis of postoperative paraffin section were collected from 490 non-endometrioid endometrial carcinoma (serous, clear cell and undifferentiated carcinoma, carcinosarcoma and mixed pathology) women in FIGO stage I.
Results: Among the 490 patients, 89.59% were detected with myometrial invasion. The methods reported for myometrial invasion assessment were frozen section in 23.47%, gross examination in 69.59%, MRI in 37.96% and CT in 10.20% of cases.
The concordance between intraoperative frozen section and postoperative paraffin section was the highest (Kappa = 0.631, accuracy = 93.04%), followed by gross examination (Kappa = 0.303, accuracy = 82.40%), MRI (Kappa = 0.131, accuracy = 69.35%), and CT (Kappa = 0.118, accuracy = 50.00%). A stable diagnostic agreement between frozen section and final results were found through years (2000–2012 Kappa = 0.776; 2013–2014 Kappa = 0.625; 2015–2016 Kappa = 0.545; 2017–2019 Kappa = 0.652).
Conclusion: In China, the assessment of myometrial invasion in non-endometrioid endometrial carcinoma is most often performed with intraoperative gross examination, but the reliability is relatively low in contrast to intraoperative frozen section. In clinical practice, frozen section is a reliable method that can help myometrial invasion accurately assessing and intraoperative decision making (lymph node dissection or not). It should be performed routinely in patients with intrauterine non-endometrioid endometrial carcinoma.
Will Anti-tax-avoidance provisions Reduce the Investment of Multinational Enterprises?
Authors: 项 炀骁 , 张 宇晨 , 张 亚璟 
Published: October 2022

Abstract
Quantitative evaluation of the effect of tax policies is of great practical significance for giving play to the structural adjustment advantages of fiscal and tax policies and strengthening the coordination between different macro-control measures. This paper takes the announcement [2016] No. 42 of the State Administration of Taxation in China as a quasi-natural experiment to study how anti-avoidance policies affect the investment level of multinational enterprises. The research finds that: (1) compared with non-multinational enterprises, multinational enterprises have significantly reduced their investment level after the promulgation of the Anti-tax-avoidance provisions; (2) The mechanism analysis shows that after the policy was issued, the tax burden, financing constraints and internal governance level of the experimental group enterprises have been improved, and the change of enterprise investment level stems from the impact of anti-avoidance policies on the above aspects of enterprises to varying degrees. Under the joint action of different mechanisms, the Anti-tax-avoidance provisions has reduced the level of enterprise investment. The conclusion of this paper provides a basis and reference for the improvement of the subsequent Anti-tax-avoidance provisions.
CD63 regulates cholesterol storage within endosomes and its distribution via exosomes
Authors: Palmulli Roberta , Couty Mickael , Piontek Melissa , Ponnaiah Maharajah , Dingli Florent , Verweij Frederik , Charrin Stéphanie , Tantucci Matteo , Sasidharan Sajitha , Rubinstein Eric , Kontush Anatol , Loew Damarys , Lhomme Marie , Roos Wouter , Raposo Graça , Niel Guillaume van 
Published: October 2022

Abstract

Exosomes are small extracellular vesicles that are enriched in specific proteins and lipids during their generation as intraluminal vesicles in multivesicular endosomes. Contrary to proteins, the endosomal sorting mechanisms of lipids on intraluminal vesicles are still ill-defined. Here, we find that the tetraspanin CD63, highly enriched in ILVs and exosomes, regulates cholesterol sorting on ILVs and exosomes. This process generates a pool of cholesterol that affects exosomes physical properties and can be mobilized by the NPC1/2 complex from ILVs and exosomes. Absence of CD63 redirects cholesterol from endosomes to the Trans-Golgi Network by actin dependent vesicular transport, placing CD63 and cholesterol at the center of a balance between inward and outward budding of endomembranes. These results establish CD63 as cholesterol sorting mechanism within endosomes and place ILVs and exosomes as alternative providers of cholesterol.
Treatment of Infected Thoracic Aortic Aneurysm with Combined Abscess Debridement and Stent-Graft Wrapping using Pedicled Latissimus Dorsi Muscle Flaps after Thoracic Endovascular Aortic Repair
Authors: Matsushima Hirokazu , Ishimine Tohru , Taniguchi Naoki , Tengan Toshiho 
Published: October 2022

Abstract
Background: Open thoracic surgery (with infected lesion removal, prosthetic graft replacement, and autologous tissue filling) has remained the main treatment for infected thoracic aortic aneurysms to date. Recent reports have highlighted good prognostic outcomes with thoracic endovascular aortic repair. However, thoracic endovascular aortic repair for infected thoracic aortic aneurysms is associated with an exacerbation of infection due to residual infected tissues. We have discussed control of refractory infections following endovascular treatment of infected thoracic aortic aneurysms
Case Presentation: An 81-year-old man, with a history of insulin-dependent diabetes mellitus and pancreaticoduodenectomy, presented to our emergency department with fever. Blood tests revealed a markedly elevated leukocyte count, and contrast-enhanced computed tomography suggested a descending thoracic aortic pseudoaneurysm. We diagnosed the patient with an infected descending thoracic aortic aneurysm, and performed urgent thoracic endovascular aortic repair; he was started on an intravenous antibiotic treatment.Postoperatively, blood tests revealed a decreased leukocyte count and the patient remained afebrile. However, computed tomography revealed temporal enlargement of the abscess cavity; therefore, an abscess debridement and stent graft wrapping with pedicled latissimus dorsi muscle flaps were performed, which successfully controlled the infection. Six weeks after abscess debridement, the patient was switched to an oral antibiotic therapy. There was no evidence of recurrence of infection 8 months after the surgery.
Conclusions: A combined abscess debridement and autologous tissue filling approach is useful for patients with poor surgical tolerance in whom infection control is difficult after thoracic endovascular aortic repair for infected thoracic aortic aneurysms. Pedicled latissimus dorsi muscle flaps are useful when using the omentum for autologous tissue filling is difficult.
Clinical algorithm reduces antibiotic use for respiratory infections in Vietnam
Authors: Nguyen Phuong TK , Nguyen Tam TM , Huynh Lan TB , Graham Stephen M , Marais Ben 
Published: October 2022

Abstract
Objective
To assess the safety and utility of a pragmatic clinical algorithm to guide rational antibiotic use in children with respiratory infection
Methods
The effect of an algorithm to guide the management of young (<5 years) children presenting with respiratory symptoms to the Da Nang Hospital for Women and Children, Vietnam, was evaluated in a before-after intervention analysis. The intervention comprised a single training session of physicians in the use of an algorithm informed by local evidence.
Results
Of the 1290 children evaluated before the intervention, 102 (7.9%) were admitted to hospital and 556/1188 (46.8%) were sent home with antibiotics. Due to COVID-19, only 166 children were evaluated after the intervention of whom 14 (8.4%) were admitted to hospital and 54/152 (35.5%) were sent home with antibiotics. Antibiotic use was reduced (from 46.8% to 35.5%; p=0.009) after clinician training, but adequate comparison was compromised. The reduction was most pronounced in children with wheeze or runny nose and no fever, or a normal chest radiograph, where antibiotic use declined from 46.7% to 28.8% (p<0.0001). The frequency of repeat presentation to hospital was similar between the two study periods (141/1188; 11.9% before and 10/152; 6.6% after; p=0.10). No child represented with serious disease after being sent home without antibiotics.
Conclusions
We observed a reduction in antibiotic use in young children with a respiratory infection after physician training in the use of a simple evidence-based management algorithm. However, the study was severely impacted by COVID-19 restrictions, requiring further evaluation to confirm the observed effect.
Classification of central nervous system tumors histological diagnosed in a single center of Northwest China 2003-2019
Authors: Zhai Yulong , Ji Peigang , Xu Meng , Chao Min , Wang Na , Liu Jinghui , Wang Yuan , Guo Shaochun , Chen Fan , Cao Haiyan , Wang Liang 
Published: October 2022

Abstract
Background:
The classification of the central nervous system (CNS) tumors has changed greatly. The Central Brain Tumor Registry of the United States (CBTRUS) and other institutions have conducted analyses on the new cases of primary CNS tumors. However, there are limited studies analyzing the incidence rate and characteristics of CNS tumors reported in China. To better understand the CNS tumors in China, we summarized the case details of all CNS primary tumors diagnosed pathologically in a single center from 2003 to 2019.
Methods:
All patients with CNS tumors who underwent neurosurgery at our Hospital from Jan 2003 to Dec 2019 were included in the study. The information of all patients was collected from the hospital information system, including diagnosis time, age, gender, anatomical sites, pathological results, etc.
Results:
A total of 17,226 cases of primary CNS tumors were retrospectively analyzed in this study. Among all cases screened, the major tumor types included meningiomas, tumors of neuroepithelial tissue, and pituicytomas. The majority of tumors of neuroepithelial tissue were glioblastoma and astrocytoma. Most tumors of neuroepithelial tissue are located in the frontal lobe. Further, the proportion of the frontal lobe increased with the grade. The median age of all patients was 46 years. The incidence of CNS tumors is higher in women than in men.
Conclusions:
Based on this data set, we analyzed various parameters including the types, biological properties, and anatomical site of CNS tumors as well as patients’ age, gender, and race, and provided researchers and clinicians with information on the incidence rate of CNS tumors.