bluuebunny/crossref_metadata_2025_split huggingface dataset:
N-Terminal Pro-B-Type Natriuretic Peptide in Risk Stratification of Heart Failure Patients With Implantable Cardioverter-Defibrillator
Authors: Deng Yu , Cheng Si-Jing , Hua Wei , Cai Min-Si , Zhang Ni-Xiao , Niu Hong-Xia , Chen Xu-Hua , Gu Min , Cai Chi , Liu Xi , Huang Hao , Zhang Shu 
Published: March 2022

BackgroundThe prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in heart failure (HF) is well-established. However, whether it could facilitate the risk stratification of HF patients with implantable cardioverter-defibrillator (ICD) is still unclear.ObjectiveTo determine the associations between baseline NT-proBNP and outcomes of all-cause mortality and first appropriate shock due to sustained ventricular tachycardia/ventricular fibrillation (VT/VF) in ICD recipients.Methods and resultsN-terminal pro-B-type natriuretic peptide was measured before ICD implant in 500 patients (mean age 60.2 ± 12.0 years; 415 (83.0%) men; 231 (46.2%) Non-ischemic dilated cardiomyopathy (DCM); 136 (27.2%) primary prevention). The median NT-proBNP was 854.3 pg/ml (interquartile range [IQR]: 402.0 to 1,817.8 pg/ml). We categorized NT-proBNP levels into quartiles and used a restricted cubic spline to evaluate its nonlinear association with outcomes. The incidence rates of mortality and first appropriate shock were 5.6 and 9.1%, respectively. After adjusting for confounding factors, multivariable Cox regression showed a rise in NT-proBNP was associated with an increased risk of all-cause mortality. Compared with the lowest quartile, the hazard ratios (HRs) with 95% CI across increasing quartiles were 1.77 (0.71, 4.43), 3.98 (1.71, 9.25), and 5.90 (2.43, 14.30) for NT-proBNP (p for trend &lt; 0.001). A restricted cubic spline demonstrated a similar pattern with an inflection point found at 3,231.4 pg/ml, beyond which the increase in NT-proBNP was not associated with increased mortality (p for nonlinearity &lt; 0.001). Fine-Gray regression was used to evaluate the association between NT-proBNP and first appropriate shock accounting for the competing risk of death. In the unadjusted, partial, and fully adjusted analysis, however, no significant association could be found regardless of NT-proBNP as a categorical variable or log-transformed continuous variable (all p &gt; 0.05). No nonlinearity was found, either (p = 0.666). Interactions between NT-proBNP and predefined factors were not found (all p &gt; 0.1).ConclusionIn HF patients with ICD, the rise in NT-proBNP is independently associated with increased mortality until it reaches the inflection point. However, its association with the first appropriate shock was not found. Patients with higher NT-proBNP levels might derive less benefit from ICD implant.
The Heat Source Origin of Geothermal Resources in Xiong’an New Area, North China, in View of the Influence of Igneous Rocks
Authors: Cui Yue , Zhu Chuanqing , Qiu Nansheng , Tang Boning , Guo Sasa , Lu Zhiwei 
Published: March 2022

The Xiong’an new area has abundant geothermal resources, and heat source research plays an important role in the geothermal system. Using the logging curve, we calculated the radioactive heat production of sedimentary layers and igneous rocks in non-sample wells; analyzed the influence of igneous rock distribution, residual heat, and its thermal increment on crust; and clarified the heat source origin of hydrothermal geothermal resources in Xiong’an new area. Sedimentary layers data (5,504) of 20 wells were converted to determine the applicable GR-A empirical relationship, and the radioactive heat production of igneous rocks with different lithologies was estimated. Finite element simulations show that igneous rock intrusions in the study area reach thermal equilibrium with the surrounding rock after 0.5 Ma at most. Upon cooling, the difference in thermal physical properties to the surrounding rock only leads to a higher heat flow of about 3.55 mW/m2 in the partial of the Niutuozhen salient. It is known that the development of igneous facies impacts the heat source. Under the geothermal background of “cold crust-hot mantle,” the mantel heat was the primary source, which the Yanshanian intrusions injected into the central salient, increasing the crustal heat by about 12% and the heat source by about 6%. The measured heat flow becomes higher in the salient (raised about 12.04 mW/m2–29.25 mW/m2) where the deep faults developed due to the groundwater convection. Heat conduction from crust-mantle heat flow and heat convection caused by deep faults are responsible for the current geothermal state in Xiong’an new area.
Simulation of Glacial Lake Outburst Flood in Southeastern Qinghai-Tibet Plateau—A Case Study of JiwenCo Glacial Lake
Authors: Zhang Yuan , Yao Xiaojun , Duan Hongyu , Wang Qi 
Published: March 2022

Glacial lake outburst floods (GLOFs) is one of the main natural disasters in alpine areas, which can cause extreme destruction to downstream settlements and infrastructures. A moraine-dammed lake named JiwenCo glacial lake (JGL) in the southeastern Qinghai-Tibetan Plateau failed on 26 June 2020, destroying many buildings, roads, bridges, and farmlands along the flow path. We reconstructed the process of this GLOF event by the Hydrological Engineering Center’s River Analysis System (HEC-RAS) and examined the JGL’s evolution (area, length, and volume) before its outburst, based on the measured cross sections and hydrological data, videos, and pictures taken by inhabitants, DEM data, and Landsat Thematic Mapper (TM)/Enhanced Thematic Mapper (ETM+)/Operational Land Imager (OLI) images. The result showed that area, length, and volume of the JGL increased by 0.20 ± 0.07 km2, 0.66 ± 0.03 km, and 0.03 ± 0.001 km3 from 1988 to 2020 (before the outburst), respectively. Approximately 0.05 km3 of water volume was discharged with the dropped water level of 15.63 m after the outburst. The peak flow was 534.4 m3/s at breach and increased to 1,408.11 m3/s at Zhongyu town. The difference between the simulated and measured peak flows in Zhongyu town was 41.88 m3/s (3.53%), showing the high accuracy of the modeling results. For villages along the river-channel, the highest velocity was found in Yiga village (14.23 m/s) and the lowest was in Gongwa village (1.22 m/s). The maximum depth was gradually increased as the river reached downstream, 8.03 m in Yiga village and 50.96 m in Duiba village. The combination of landslide, high temperature, and extremely heavy precipitation resulted in this GLOF disaster. An integrated disaster prevention and mitigation plan needs to be developed for susceptible areas such as Niduzangbo basin that experienced two GLOFs in recent 10 years.
Childhood ADHD, Going Beyond the Brain: A Meta-Analysis on Peripheral Physiological Markers of the Heart and the Gut
Authors: Payen Ameanté , Chen Michelle J. , Carter T. Grace , Kilmer Ryan P. , Bennett Jeanette M. 
Published: March 2022

Attention-Deficit/Hyperactivity Disorder (ADHD) is the most common neurodevelopmental disorder diagnosed in children. Questions regarding its increased diagnostic rates and pharmacological treatments in developing children have led to a more holistic review of the multi-system pathophysiology observed in ADHD. The dopaminergic neurotransmitter system, known for its influence on reward-motivated behaviors and motor control, and the frontostriatal systems, that mediate motor, cognition, and behavior, are associated with ADHD’s development. However, studies have shown that these neural systems do not wholly account for ADHD’s multilayered and heterogeneous symptom presentation. For instance, the literature suggests that emotional dysregulation, the inability to regulate one’s emotional responses to provoking stimuli, is associated with increased risk for social impairment in ADHD. A broader examination of physiological systems in children with ADHD has found potential markers in the heart-brain and gut-brain axes that correspond with certain behaviors associated with emotional dysregulation in recent studies. Hence, the purpose of this meta-analysis is to aggregate ten applicable published case studies and analyze task-related heart rate reactivity (HRR; n = 5 studies) and gut microbiota (n = 5 studies) data in children with and without ADHD. Data from a total of 531 youth with ADHD and 603 youth without ADHD revealed significant small and medium effect sizes for higher Chao1 levels and Actinobacteria levels in the ADHD group, respectively, but no evidence of altered task-related HRR. Thus, further research into multi-system psychophysiological measures of emotional dysregulation and ADHD is warranted. The clinical, empirical, and educational implications of these findings are discussed.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier PROSPERO (CRD42021236819).
Risk Factors and Prognosis for Metastatic Follicular Thyroid Cancer
Authors: Wu Ming-Hsien , Lee Yi-Yin , Lu Yu-Ling , Lin Shu-Fu 
Published: March 2022

BackgroundFollicular thyroid cancer (FTC) is the second most common malignancy of thyroid. About 7%–23% of patients with FTC have distant metastasis. The aim of this study was to investigate the risk factors associated with distant metastasis and the impact of distant metastasis on survival in FTC patients.MethodsPatients with FTC were analyzed using a prospectively maintained dataset of thyroid cancer registered at a tertiary hospital in Taiwan between December 1976 and May 2020.ResultsA total of 190 patients with a mean follow-up of 7.7 years were included in this study, including 29 with distant metastasis at diagnosis, 14 who developed metastasis during follow-up, and 147 without metastasis. Multivariate analysis adjusted for age, gender, tumor stage, and extrathyroidal invasion revealed old age (≥ 55 years) (adjusted odds ratio, 27.6; 95% confidence interval [CI], 8.75–86.8; P &lt; 0.001) and extrathyroidal invasion (odds ratio, 24.1; 95% CI, 3.50–166.5; P = 0.001) were significantly associated with an increased risk of distant metastasis. Metastasis was correlated with higher cancer-specific mortality (adjusted hazard ratio, 35.5; 95% CI, 6.1–206.1; P &lt; 0.001). In addition, patients with metastatic FTC diagnosed on initial presentation had the lowest 10-year cancer-specific survival rate (26.0%), followed by those who developed metastatic disease after initial treatment (76.6%), while patients without metastasis were all alive (100%) (P ≤ 0.002 for all comparisons).ConclusionsAge and extrathyroidal invasion are significant risk factors for distant metastasis of FTC. Patients with metastatic FTC, especially when diagnosed on initial presentation, have dismal survival outcomes.
MiR-200c-3p Regulates DUSP1/MAPK Pathway in the Nonalcoholic Fatty Liver After Laparoscopic Sleeve Gastrectomy
Authors: Zhang Tao-tao , Wang Yong , Zhang Xiang-wen , Yang Ke-yu , Miao Xiu-qin , Zhao Guo-hua 
Published: March 2022

AimNon-alcoholic fatty liver disease (NAFLD) is a health burden worldwide, which is closely related to obesity. The effect of sleeve gastrectomy (SG) on NAFLD is efficient, and the underlying mechanism remains unknown. Our study sought to investigate the mechanism of dual-specificity protein phosphatase 1 (DUSP1) expression regulation following the SG procedure in NAFLD patients and C57BL/6J mice via miR-200c-3p.MethodsThe serum was extracted from NAFLD patients who underwent laparoscopic sleeve gastrectomy (LSG) and volunteers. Next, the correlation between miR-200c-3p and DUSP1 was identified in vitro. NAFLD mice were modelled by high-fat diets (HFD). The hepatic tissue expression levels of miR-200c-3p, DUSP1, phospho-extracellular regulated protein kinases1/2 (p-ERK1/2), phospho -p38 mitogen-activated protein kinases (p-p38), and phospho-c-Jun N-terminal kinases (p-JNK) induced by SG procedure were evaluated.ResultsThe SG procedure contributed to significant weight loss, reduced lipids in NAFLD patients and mice. The increased expression level of miR-200c-3p and reduced expression of DUSP1 were observed in NAFLD patients and mice (p&lt;0.05). The reduced expression levels of miR-200c-3p and increased expression of DUSP1 were observed in patients and mice with NAFLD who underwent SG procedure. DUSP1 is a potential target of miR-200c-3p.ConclusionsA novel mechanism was identified in which miR-200c-3p regulates the MAPK-dependent signals that are linked to the promotion of hepatosteatosis via DUSP1 after sleeve gastrectomy. The findings suggested that miR-200c-3p should be further explored as a potential target for the treatments of NAFLD.
Localization of Nerve Growth Factor Expression to Structurally Damaged Cartilaginous Tissues in Human Lumbar Facet Joint Osteoarthritis
Authors: Seidel Matthias F. , Netzer Cordula , Chobaz Véronique , Hügle Thomas , Geurts Jeroen 
Published: March 2022

PurposeNerve Growth Factor (NGF) is a pivotal mediator of chronic pain and plays a role in bone remodelling. Through its high affinity receptor TrkA, NGF induces substance P (SP) as key downstream mediator of pain and local inflammation. Here we analysed NGF, TrkA and SP tissue distribution in facet joint osteoarthritis (FJOA), a major cause of chronic low back pain.MethodsFJOA specimens (n=19) were harvested from patients undergoing intervertebral fusion surgery. Radiologic grading of FJOA and spinal stenosis, followed by immunohistochemistry for NGF, TrkA and SP on consecutive tissue sections, was performed in ten specimens. Explant cultures (n=9) were used to assess secretion of NGF, IL-6, and SP by FJOA osteochondral tissues under basal and inflammatory conditions.ResultsNGF was predominantly expressed in damaged cartilaginous tissues (80%), occasionally in bone marrow (20%), but not in osteochondral vascular channels. NGF area fraction in cartilage was not associated with the extent of proteoglycan loss or radiologic FJOA severity. Consecutive sections showed that NGF and SP expression was localized at structurally damaged cartilage, in absence of TrkA expression. SP and TrkA were expressed in subchondral bone marrow in both presence and absence of NGF. Low level NGF, but not SP secretion, was detected in four out of eighteen FJOA explants under both basal or inflammatory conditions (n=2 each).ConclusionNGF is associated with SP expression and structural cartilage damage in osteoarthritic facet joints, but not with radiologic disease severity. NGF tissue distribution in FJOA differs from predominant subchondral bone expression reported for knee OA.
Soluble Immune-Related Proteins as New Candidate Serum Biomarkers for the Diagnosis and Progression of Lymphangioleiomyomatosis
Authors: Liu Xuefei , Xu Yanping , Wu Xueying , Liu Yanpu , Wu Qiang , Wu Jialiang , Zhang Henghui , Zhou Min , Qu Jieming 
Published: March 2022

BackgroundThe goal of this study was to analyze serum from lymphangioleiomyomatosis (LAM) patients and healthy controls to identify novel biomarkers that could shed light on disease diagnosis and pathogenesis.MethodsFrom April 2017 to October 2019, qualified serum samples were obtained to explore differences in 59 immune proteins between 67 LAM patients and 49 healthy controls by the Luminex method.ResultsWe characterized 22 serum immune proteins that were differentially expressed in LAM patients compared with healthy people. Fifty-nine proteins were then classified into eight categories according to their biological function, and the results showed that LAM patients displayed significantly higher levels of growth factors (p = 0.006) and lower levels of costimulatory molecules (p = 0.008). LAG-3 was not only likely to have better predictive value than VEGF-D but also showed a significant difference between patients without elevated VEGF-D and healthy people. IL-18 was positively correlated with lung function and six-minute walk test (6MWT) distance and negatively correlated with St. George’s Respiratory Questionnaire (SGRQ) score and pulmonary artery systolic pressure (PASP), which suggested that IL-18 was related to disease severity. PD-1 was significantly different between patients with pneumothorax and/or chylothorax and those without complications.ConclusionWe performed a large-scale serum immune factor analysis of LAM. Our study provides evidence that LAG-3 may be a novel candidate serum biomarker for the diagnosis of LAM. Future independent validation in prospective studies is warranted.
Influence of Surface Heterogeneity on Morphology of Interfacial Nanobubble
Authors: Yang Haichang , Zhang Fanfan , Xing Yaowen , Gui Xiahui , Cao Yijun 
Published: March 2022

Gaseous domains formed on solid–liquid interface have attracted scientists’ attentions in recent 2 decades, and the existence of interfacial nanobubble (INB) has been basically confirmed. However, an overall understanding on INB is still lacking. This research studied the influence of surface chemical heterogeneity on the morphology of INB by molecular dynamics simulations technique. The results showed that the gaseous domains could not nucleate on the hydrophilic substrate, while only dense gas layer (DGL) could be observed from the time-averaged density map for homogeneously hydrophobic substrate due to the random moving of INB. If there was a hydrophobic patch on the hydrophilic surface, INB could form on the hydrophobic patch with contact line being pinned at the boundary of the patch. In this case, the contact angle (gas-side) increased with the gas oversaturation degree and decreased with surface hydrophobicity of the patch. For the case that there existed a more hydrophobic patch/site on the hydrophobic surface, the INB could have moved randomly along the hydrophobic surface, but its receding contact line was pinned by the more hydrophobic patch/site. Hence, the INB could only move in the vicinity of this pinning patch/site, so that an INB profile instead of a DGL formed due to the pinning effect, and the apparent contact angle of the INB is significantly lower than the actual one. Throughout this study, the apparent INB we observed from experiments may be different from its instantaneous state and is significantly affected by surface heterogeneity.
Efficacy of Intense Pulsed Light in the Treatment of Recurrent Chalaziosis
Authors: Zhu Yirui , Huang Xiaodan , Lin Lin , Di Mengshu , Chen Ruida , Dong Jilian , Jin Xiuming 
Published: March 2022

PurposeHigh recurrence rate of chalaziosis and serious side effects of repeated surgical excision may help increase awareness of recurrent and refractory chalaziosis as a serious disorder affecting many aspects of life. This present study was aimed to investigate the efficacy and safety of intense pulse light (IPL) therapy and meibomian gland expression (MGX) in cases of recurrent chalaziosis after excision surgery.MethodsForty-two consecutive recurrent chalaziosis cases (35 patients) treated with IPL-MGX were enrolled. All patients initially underwent excision with curettage. One week after lesion excision, IPL-MGX were performed at least 3 times. Another set of age- and sex-matched consecutive cases of recurrent chalaziosis, who received excision with curettage, but went without IPL-MGX treatment, were collected to calculate recurrence rate. Treatment efficacy and safety were measured before IPL-MGX treatment and 1 month after the final treatment.ResultsThe majority of patients received 4 sessions of IPL-MGX therapy (20 patients; 57.1%) or 3 sessions of IPL-MGX therapy (10 patients; 28.6%), resulting in a lower recurrence rate of 11.4% compared to that of recurrent chalaziosis without IPL-MGX cases (45.6%, P &lt; 0.001). The NIBUT was significantly prolonged from 3.9 ± 1.8 to 5.1 ± 1.7 s at 4 weeks after the final treatment (P = 0.001). Similarly, mean TMH score improved and was statistically significant when compared with baseline (0.17 ± 0.07 vs. 0.21± 0.09; P = 0.008). Furthermore, meibum quality and expressibility scores significantly improved at 4 weeks following the final treatment (both P &lt; 0.001). Other variables, such as intraocular pressure and visual acuity, remained unaffected following treatment.ConclusionThe combination of IPL treatment and MGX offers a low risk and effective option in decreasing the recurrence rate of recurrent chalaziosis by improving meibomian gland function. IPL-MGX may be considered for first-line treatment in recurrent or refractory cases post excision.
A Case Report of Neuronal Intranuclear Inclusion Disease Presenting With Recurrent Migraine-Like Attacks and Cerebral Edema: A Mimicker of MELAS
Authors: Xie Fei , Hu Xingyue , Liu Peng , Zhang Dan 
Published: March 2022

BackgroundNeuronal intranuclear inclusion disease (NIID) is a progressive neurodegenerative disease associated with the GGC repeats in the 5'-untranslated region (5'UTR) of NOTCH2NLC. NIID exhibits a wide range of clinical manifestations. However, patients presenting with recurrent migraine-like attacks and cerebral edema have only rarely been reported.Case PresentationA Chinese female suffered probable migraines with aura for 10 years. At age of 51, aggravating migraine-like attacks co-occurred with a sudden encephalopathy-like episode. Brain MRI showed right cerebral edema and cortical enhancement. Serum lactic acid level was elevated at rest and significantly increased after a simplified serum lactic acid exercise test. The initial diagnosis was MELAS, while NIID was suspected after faint DWI high-intensity signals in the corticomedullary junction was retrospectively recognized. Mitochondrial genome sequencing and gene panel analysis of nuclear genes related to mitochondrial diseases failed to find any causative variants. Repeat-primed PCR and fluorescence amplicon length PCR of NOTCH2NLC gene identified an abnormal expansion of 118 GGC repeats in the 5'UTR of NOTCH2NLC gene.ConclusionNIID should be taken into account for differential diagnosis of migraines and MELAS-like episodes. Besides the corticomedullary hyperintensity on DWI, cortical enhancement in contrast-enhanced brain MRI may also be a brain image marker for the differential diagnosis between MELAS and NIID with MELAS-like episodes.