bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time‐Resolved Luminescent Sensing and Imaging for Enzyme Catalytic Activity Based on Responsive Probes
Authors: Wang Jiawei , Jin Yibiao , Li Mingdang , Liu Shujuan , Kam‐Wing Lo Kenneth , Zhao Qiang 
Published: July 2022

AbstractEnzymes, as a kind of biomacromolecules, play an important role in many physiological processes and relate directly to various diseases. Developing an efficient detection method for enzyme activity is important to achieve early diagnosis of enzyme‐relevant diseases and high throughput screening of potential enzyme‐relevant drugs. Time‐resolved luminescence assay provide a high accuracy and signal‐to‐noise ratios detection methods for enzyme activity, which has been widely used in high throughput screening of enzyme‐relevant drugs and diagnosis of enzyme‐relevant diseases. Inspired by these advantages, various responsive probes based on metal complexes and metal‐free organic compounds have been developed for time‐resolved bioimaging and biosensing of enzyme activity owing to their long luminescence lifetimes, high quantum yields and photostability. In this review, we comprehensively reviewed metal complex‐ and metal‐free organic compound‐based responsive probes applied to detect enzyme activity through time‐resolved imaging, including their design strategies and sensing principles. Current challenges and future prospects in this rapidly growing field are also discussed.
Supramolecular Hydrogel Based on Pseudopolyrotaxane Aggregation for Bacterial Microenvironment‐Responsive Antibiotic Delivery
Authors: Zhang Rui , Liang Xiaoyang , Wang Jia , Yu Bingran , Li Yang , Xu Fu‐Jian 
Published: July 2022

AbstractDue to the extensive use of antibiotics, the variety and number of drug‐resistant pathogens have increased dramatically and have become a major global health problem. This imposes significant demands on the rational and effective use of antibiotics. To this end, a supramolecular hydrogel based on pseudopolyrotaxanes aggregation is proposed for antibiotic delivery. Supramolecular cross‐linking strategies allow hydrogels to be obtained under mild conditions that facilitate the encapsulation of antibiotics. The presence of pH‐sensitive imine bonds allows for the reversible detachment of PEG residues from the PEGylated hyaluronic acid backbone in an acidic environment, which leads to reversible changes in hydrogel crosslink density and thus controls antibiotic release behavior. Antimicrobial assessments indicated that the hydrogel exhibited good antimicrobial efficiency against both Gram‐positive and negative bacteria, while responding to the bacterial microenvironment and enabling a burst release of antibiotics in severe infections. The proposed hydrogel also has excellent biocompatibility and thus possesses great potential for biomedical applications.
Health-related quality of life following total minimally invasive, hybrid minimally invasive or open oesophagectomy: a population-based cohort study
Authors: Klevebro F , Kauppila J H , Markar S , Johar A , Lagergren P 
Published: July 2022

Abstract

Background
Minimally invasive oesophagectomy has been shown to reduce the risk of pulmonary complications compared with open oesophagectomy, but the effects on health-related quality of life (HRQoL) and oesophageal cancer survivorship remain unclear. The aim of this study was to assess the longitudinal effects of minimally invasive compared with open oesophagectomy for cancer on HRQoL.

Methods
All patients who had surgery for oesophageal cancer in Sweden from January 2013 to April 2018 were identified. The exposure was total or hybrid minimally invasive oesophagectomy, compared with open surgery. The study outcome was HRQoL, evaluated by means of the European Organisation for Research and Treatment of Cancer questionnaires QLQ-C30 and QLQ-OG25 at 1 and 2 years after surgery. Mean differences and 95 per cent confidence intervals were adjusted for confounders.

Results
Of the 246 patients recruited, 153 underwent minimally invasive oesophagectomy, of which 75 were hybrid minimally invasive and 78 were total minimally invasive procedures. After adjustment for age, sex, Charlson Co-morbidity Index score, pathological tumour stage and neoadjuvant therapy, there were no clinically and statistically significant differences in overall or disease-specific HRQoL after oesophagectomy between hybrid minimally invasive and total minimally invasive surgical technique versus open surgery.

Conclusion
In this population-based nationwide Swedish study, longitudinal HRQoL after minimally invasive oesophagectomy was similar to that of the open surgical approach.
Belief, attitude and critical understanding. A systematic review of social justice in Service‐Learning experiences
Authors: Compare Christian , Albanesi Cinzia 
Published: July 2022

AbstractThis systematic review examined the role of Service‐Learning experiences promoted by higher education institutions to strengthen the achievement of social justice outcomes among youth. We screened and coded studies following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA). Of the 555 articles found in the database search, 47 peer‐reviewed studies were included in the final sample. Social justice construct, together with research location, participants, target community and outcomes, were coded. Results show effects of Service‐Learning experiences on (a) fostering significant improvement of students' social justice beliefs, (b) stimulating significant changes in students' attitudes with respect to the development of altruistic behaviours and their commitment to social justice, and (c) increasing students' critical understanding by sparking questioning processes related to personal assumptions of inequalities. This systematic review provides insights into the strengths and challenges of implementing social justice‐oriented Service‐Learning experiences.
Fungistatic Films Containing Cinnamon Essential Oil: New Coatings to Preserve the Nutraceutical Content of Avocado Fruit against Fusariosis
Authors: Coyotl‐Pérez Wendy Abril , Morales‐Rabanales Quetzali Nicte , Lozoya‐Gloria Edmundo , Becerra‐Martínez Elvia , Ramírez‐García Sergio A. , Mosso‐González Clemente , Villa‐Ruano Nemesio 
Published: July 2022

AbstractAvocadoes are a rich source of nutrients and nutraceuticals that preserve human health. Nevertheless, this fruit is susceptible to phytopathogen infection during the postharvest period causing severe economic losses. Herein, we report on the in situ antifungal assessment of biodegradable films impregnated with the essential oil of Cinnamomum verum (CvEO) as natural fungistatic coatings to extend postharvest quality of Hass avocadoes (Persea americana cv. Hass). These coatings were evaluated on fruits previously infected with a native strain of Fusarium verticillioides. The cytotoxic assessment of CvEO on F. verticillioides revealed a minimum inhibitory concentration of 0.3±0.0 g L−1 whereas its chemical profiling showed (E)‐cinnamaldehyde (45.9 %) 1,3,8‐p‐menthatriene (7.9 %) and linalool (6.8 %) as the major bioactive compounds. Four coatings (FC1–FC4) were made using chitosan (1 %) and a diverse quantity of CvEO (0.4–1.3 % w/v). The physicochemical properties demonstrated that the films FC3 and FC4 have the optimal characteristics of a food coating. Avocadoes preserved with the films FC3 and FC4 substantially kept (p<0.01) fruit firmness and the nutraceutical content of infected avocados at least for 21 d. The results of the present investigation suggest that our hybrid materials can conserve basic nutritional parameters such as fiber, protein, reducing sugars, as well as the content of unsaturated fatty acids which are the main nutraceuticals of this fruit.
Tamoxifen modulates mitochondrial dynamics through AMPK and MAPK during nutrition deprivation
Authors: Vijayakumar Gangipangi , Swetha Uppalapati S. , Sudhagar Selvaraju 
Published: July 2022

AbstractThe interaction of cancer cells with their tumor microenvironment determines key events in the progression of the disease, therapeutic efficacy, and the development of drug resistance. Here, we presented evidence that tamoxifen support breast cancer growth during nutrition deprivation by modulating mitochondrial dynamics through AMPK and MAPK signaling. Tamoxifen enhances mitochondrial fusion under nutrition‐deprived conditions by suppressing Drp1 ser616 phosphorylation and upregulating Mfn1 levels. Tamoxifen‐induced mitochondrial fusion is mediated by the activation of AMPK as evident by the pharmacological inhibition of AMPK reverse mitochondrial fusion. Interestingly, JNK activation by tamoxifen controls the mitochondrial fusion morphology by downregulating Mfn2. Collectively, tamoxifen support cell growth by enhancing mitochondrial fusion by regulating stress kinase signaling under nutrition deprivation condition.
SAT2 regulates Sertoli cell–germline interactions via STIM1‐mediated ROS/WNT/β‐catenin signaling pathway
Authors: Chen Xia , Zheng Yanli , Han Yun , He Hui , Lv Jinxing , Yu Jun , Li Hong , Hou Shunyu , Shen Cong , Zheng Bo 
Published: July 2022

AbstractAs the main component of seminiferous tubules, Sertoli cells are in close contact with germ cells and generate niche signals, which exhibit pivotal functions in spermatogenesis and male fertility. However, the regulatory mechanisms of Sertoli cell–germline interactions (SGIs) in the testes of neonatal mice (NM) remain largely unclear. Previously, we identified spermidine/spermine N1‐acetyl transferase 2 (SAT2) and stromal interaction molecule 1 (STIM1) to be potential regulators of testicular cord formation via comparative proteomics analysis. Here, we demonstrated a novel role of SAT2 for SGIs during testicular development in NM. Testicular explants lacking SAT2 affected the mislocation, but not the quantity, of Sertoli cells, which led to maintenance defects in spermatogonial stem cells (SSCs). Interestingly, SAT2 was essential for the migration of TM4 cells, a Sertoli cell line. Mechanistically, SAT2 was able to bind STIM1, repress its expression, and regulate homeostasis of a reactive oxygen species/wingless type (WNT)/β‐catenin pathway in NM testes. Collectively, our study identified that SAT2 was able to regulate SGIs via a STIM1‐mediated WNT signaling pathway.
Contrast‐associated acute kidney injury: Type may not matter
Authors: Krishnamoorthy Parasuram , Dangas George 
Published: July 2022

Key Points
CA‐AKI is associated with increased short and long term morbidity and mortality
Despite significant variation in contrast type utilization, contrast type was not associated with incidence of MARCE
Difference among low‐ and iso‐osmolar contrast media studies appear rather negligible from clinical point of view
High‐entropy alloy catalysts: From bulk to nano toward highly efficient carbon and nitrogen catalysis
Authors: Yu Lanlan , Zeng Kaizhu , Li Chenghang , Lin Xiaorong , Liu Hanwen , Shi Wenhui , Qiu Hua‐Jun , Yuan Yifei , Yao Yonggang 
Published: July 2022

AbstractHigh‐entropy alloys (HEAs) have attracted widespread attention as both structural and functional materials owing to their huge multielement composition space and unique high‐entropy mixing structure. Recently, emerging HEAs, either in nano or highly porous bulk forms, are developed and utilized for various catalytic and clean energy applications with superior activity and remarkable durability. Being catalysts, HEAs possess some unique advantages, including (1) a multielement composition space for the discovery of new catalysts and fine‐tuning of surface adsorption (i.e., activity and selectivity), (2) diverse active sites derived from the random multielement mixing that are especially suitable for multistep catalysis, and (3) a high‐entropy stabilized structure that improves the structural durability in harsh catalytic environments. Benefited from these inherent advantages, HEA catalysts have demonstrated superior catalytic performances and are promising for complex carbon (C) and nitrogen (N) cycle reactions featuring multistep reaction pathways and many different intermediates. However, the design, synthesis, characterization, and understanding of HEA catalysts for C‐ and N‐involved reactions are extremely challenging because of both complex high‐entropy materials and complex reactions. In this review, we present the recent development of HEA catalysts, particularly on their innovative and extensive syntheses, advanced (in situ) characterizations, and applications in complex C and N looping reactions, aiming to provide a focused view on how to utilize intrinsically complex catalysts for these important and complex reactions. In the end, remaining challenges and future directions are proposed to guide the development and application of HEA catalysts for highly efficient energy storage and chemical conversion toward carbon neutrality.
Bola‐Amphiphilic Glycodendrimers: New Carbohydrate‐Mimicking Scaffolds to Target Carbohydrate‐Binding Proteins
Authors: Zhang Wenzheng , Dhumal Dinesh , Zhu Xiaolei , Ralahy Brigino , Ellert‐Miklaszewska Aleksandra , Wu Jing , Laurini Erik , Yao Yi‐Wen , Kao Chai‐Lin , Iovanna Juan L. , Pricl Sabrina , Kaminska Bozena , Xia Yi , Peng Ling 
Published: July 2022

AbstractDendrimers are appealing scaffolds for creating carbohydrate mimics with unique multivalent cooperativity. We report here novel bola‐amphiphilic glycodendrimers bearing mannose and glucose terminals, and a hydrophobic thioacetal core responsive to reactive oxygen species. The peculiar bola‐amphiphilic feature enabled stronger binding to lectin compared to conventional amphiphiles. In addition, these dendrimers are able to target mannose receptors and glucose transporters expressed at the surface of cells, thus allowing effective and specific cellular uptake. This highlights their great promise for targeted delivery.
Chelating Phosphorus–An O, C, O‐Coordinating Pincer‐Type Ligand Coordinating PIII and PV Centres
Authors: Gock Michael , Lutter Michael , Pintus Anna , Schollmeier Dieter , Arca Massimiliano , Lippolis Vito , Jurkschat Klaus 
Published: July 2022

AbstractThe sequence of reactions of the phosphorus‐containing aryllithium compound 5‐t‐Bu‐1,3‐[(P(O)(O‐i‐Pr)2]2C6H2Li (ArLi) with Ph2PCl, KMnO4, elemental sulfur and elemental selenium, respectively, gave the aryldiphenylphosphane chalcogenides 5‐t‐Bu‐1,3‐[(P(O)(O‐i‐Pr)2]2C6H2P(E)Ph2 (1, E=O; 2, E=S; 3, E=Se). Compound 1 partially hydrolysed giving [5‐t‐Bu‐1‐{(P(O)(O‐i‐Pr)2}‐3‐{(P(O)(OH)2}C6H2]P(O)Ph2 (4). The reaction of ArLi with PhPCl2 provided the benzoxaphosphaphosphole [1(P), 3(P)‐P(O)(O‐i‐Pr)OPPh‐6‐t‐Bu‐4‐P(O)(O‐i‐Pr)2]C6H2P (5i) as a mixture of the two diastereomers. The oxidation of 5i with elemental sulfur gave the benzoxaphosphaphosphole sulfide [1(P), 3(P)‐P(O)(O‐i‐Pr)OP(S)Ph‐6‐t‐Bu‐4‐P(O)(O‐i‐Pr)2]C6H2 (5) as pair of enantiomers P1(R), P3(S)/P1(S), P3(R) of the diastereomer (RS/SR)‐5 (5b). The aryldiphenylphosphane 5‐t‐Bu‐1,3‐[(P(O)(O‐i‐Pr)2]2C6H2PPh2 (6) was obtained from the reaction of the corresponding aryldiphenylphosphane sulfide 2 with either sodium hydride, NaH, or disodium iron tetracarbonyl, Na2Fe(CO)4. The oxidation of the aryldiphenylphosphane 6 with elemental iodine and subsequent hydrolysis yielded the aryldiphenyldioxaphosphorane 9‐t‐Bu‐2,6‐(OH)‐4,4‐Ph2‐3,5‐O2‐2,6‐P2‐4λ5‐P‐[5.3.1.0]‐undeca‐1(10),7(11),8‐triene (7). Both of its diastereomers, (RR/SS)‐7 (7a) and (RS/SR)‐7 (7b), were separated as their chloroform and i‐propanol solvates, 7a⋅2CHCl3 and 7b⋅i‐PrOH, respectively. DFT calculations accompanied the experimental work.
Flexible Alkylene Bridges as a Tool To Engineer Crystal Distyrylbenzene Structures Enabling Highly Fluorescent Monomeric Emission
Authors: Shimomura Yoshimichi , Igawa Kazunobu , Sasaki Shunsuke , Sakakibara Noritaka , Goseki Raita , Konishi Gen‐ichi 
Published: July 2022

AbstractTo design ultrabright fluorescent solid dyes, a crystal engineering strategy that enables monomeric emission by blocking intermolecular electronic interactions is required. We introduced propylene moieties to distyrylbenzene (DSB) as bridges between the phenyl rings either side of its C=C bonds. The bridged DSB derivatives formed compact crystals that emit colors similar to those of the same molecules in dilute solution, with high quantum yields. The introduction of flexible seven‐membered rings to the DSB core produced moderate distortion and steric hindrance in the DSB π‐plane. However, owing to this strategy, it was possible to control the molecular arrangement with almost no decrease in the crystal density, and intermolecular electronic interactions were suppressed. The bridged DSB crystal structure differs from other DSB derivative structures; thus, bridging affords access to novel crystalline systems. This design strategy has important implications in many fields and is more effective than the conventional photofunctional molecular crystal design strategies.
Privacy preserving mobile forensic framework using role‐based access control and cryptography
Authors: Hyder Muhammad Faraz , Arshad Saadia , Arfeen Asad , Fatima Tasbiha 
Published: July 2022

SummaryThe rise of social media‐related crimes has led to the rise of mobile forensics. Since mobile forensics and privacy preservation are conflicting fields, it is important to find a middle ground where forensics can be performed on any device without compromising the confidentiality of an individual. This paper presents a framework called “role‐based mobile forensics framework with cryptography (RBMF2C)” that can be easily implemented and protects users' privacy and does not interfere with the forensic process. A mobile forensic platform called Sher‐locked phones developed using C# is also presented in this paper that is developed following the aforementioned RBMF2C framework. This platform consists of five layers: access control, evidence gathering, data analysis, privacy, and reporting layer. The developed platform implements the RBMF2C framework on the evidence gathering, analysis, and reporting layer to protect the evidential image, evidential findings, and final report from being accessed by unauthorized users. The implementation of privacy preservation techniques as proposed by the proposed framework such as role‐based access control, keyword search, and encryption/ decryption did not hinder the performance of the developed toolkit, and suspects data privacy is also preserved to a substantial extent.
An energy‐efficient clustering algorithm combined interval type‐2 fuzzy logic and dual‐super‐cluster‐head mechanism for homogeneous wireless sensor networks of mobile sink
Authors: Yan Xiao , Gan Jianyuan , Wang Lili , Wu Xiaobei 
Published: July 2022

SummaryIn recent trends, wireless sensor network (WSN) is often used in harsh environments. When WSNs work, they need to deploy a large number of sensor nodes in the monitoring area. Due to the limited resources carried by the sensor nodes, the monitoring process of WSN will be limited by the energy of the sensor nodes. An energy‐efficient clustering algorithm combining interval type‐2 fuzzy logic and dual‐super‐cluster‐head (IT2FL‐DSCH) mechanism is proposed, aiming at reducing and balancing the energy consumption of sensor nodes. Considering the four fuzzy parameters, that is, cluster heads' (CHs') battery power, CHs' centrality, base station's (BS's) mobility, and the distance from CHs to BS, interval type‐2 fuzzy logic (IT2FL) is used to select the appropriate super cluster head (SCH). And SCH is the only way to communicate with the mobile BS, thus effectively using bandwidth. Then, the DSCH mechanism to balance the energy consumption of SCH is introduced in detail. In addition, we utilize mathematical derivation to obtain the supremum of the energy consumption of the SCH algorithm under different network distribution. Finally, the MATLAB simulation results show that this protocol outperforms low energy adaptive clustering hierarchy (LEACH), LEACH‐centralized (LEACH‐C), distributed energy efficient clustering (DEEC), WSNs using deep‐Q‐networks (DQN), and two‐tier distributed fuzzy logic based protocol (TTDFP) in terms of sensor nodes energy saving, network stability, and network lifetime.
Performance of NOMA‐assisted MRC receivers in presence of imperfect SIC and CSI errors
Authors: Soni Sandhya , Jain Monika , Rawal Divyang , Sharma Nikhil , Gupta Akash 
Published: July 2022

SummaryIn this paper, we analyze the performance of maximum‐ratio combining (MRC) receivers for single‐input multiple‐output (SIMO) non‐orthogonal multiple access (NOMA) system. We explore the aforesaid system performance in presence of impairments like imperfect channel state information (CSI) and successive interference cancellation (SIC) errors. In general, receive diversity provides diversity gain and helps to maintain quality of service (QoS), while the NOMA system achieves higher spectral efficiency compared to orthogonal multiple access (OMA). Power‐domain NOMA system transmits superimposed‐coded signal, which utilize SIC detection method at the receiving users. Here, we derive the closed‐form expression of the average bit error rate (BER) for the MRC‐based NOMA system. We also analyze the performance of the system in high signal‐to‐noise ratio (SNR) regime through derived asymptotic expression. Furthermore, the outage probability, diversity order, and sum rate comparison between NOMA and OMA system are also presented. Simulation results also validate the derived theoretical expressions and confirm the diversity gain achieved for the considered system.
Self‐concept, creativity and developmental dyslexia in university students: Effects of age of assessment
Authors: Brunswick Nicola , Bargary Serena 
Published: July 2022

Educational experiences often influence self‐concept. Thus, readers with dyslexia can have low self‐esteem and self‐efficacy, and perceive themselves as less intelligent than their peers. They may develop creativity to succeed despite their difficulties but findings are inconsistent and rarely consider the effect of age of assessment on self‐perception. This study included 145 university students (Mage = 24.43 years), 72 with dyslexia; of these, 53% had been assessed in childhood (Mage = 11.89 years), 47% in adulthood (Mage = 27.38 years). A survey assessed self‐esteem, self‐efficacy, creativity and estimated intelligence. Students with dyslexia reported lower levels of self‐esteem, self‐efficacy and estimated intelligence. When assessment age was considered, those assessed early displayed lower self‐esteem and self‐efficacy but no difference in estimated intelligence. Those assessed late displayed lower estimated intelligence and self‐esteem but no difference in self‐efficacy. Findings highlight the importance of providing psychological support to students with dyslexia to enhance their self‐perceptions.