bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparative Study of The Effect of Selectivity of COX-2 Inhibition (Meloxicam & Celecoxib) on Some Cardiovascular RiskMarkers in Patients With Rheumatoid Arthritis
Authors: Hadi Ali Mohammed , Ali Shatha Hussein 
Published: April 2022

Background: Prostaglandin G/H Synthases (Cyclooxygenases) are enzymes that catalyze the conversion of arachidonic acid to a series of compounds endingin prostaglandins, endogenous compounds triggering many biological & physiological events in many systems including circulatory & renal systems.The normal balance between Cox-1 derived thromboxane A2 (TXA2) which acts as a platelet activator enhancing thrombosis, & the antithrombotic cardioprotective effects of prostacyclin (PGI2) which is produced through Cox-2 activity. Thus inhibition of Cox-2 derived PGI2 will exaggerate the cardiovascular effects of TXA2. Cyclooxygenase - 2 (Cox-2) inhibitors have different odds on cardiovascular risk factors through selectivity to that enzymethat could play a role in their pharmacological action.Objective: Our study includes a comparison between the effects of the purely cox-2 selective inhibitor (Celecoxib), and the relatively Cox-2 selective inhibitor(Meloxicam) on some cardiovascular risk markers in patients suffering from rheumatoid arthritis.Materials &Methods: Thirty –six patients were selected as having rheumatoid arthritis (RA) with age range of 30-60 years (48±9.72), in addition to a group ofnormal subjects (12) were included as a control group Specific biochemical investigations based on measuring highly sensitive kit for serum C – reactiveprotein (hs-CRP), serum creatine kinase( CK), serum aspartate aminotransferase(AST), serum urea, serum creatinine, and serum lipid profile.The patients were treated with celecoxib 400mg/day or with meloxicam 15mg/day for 3 months period.Results: Both drugs were able to reduce (significantly) the highly sensitive Creactive protein and increase serum total cholesterol, Low Density Lipoprotein/High Density Lipoprotein (LDL/HDL) ratio as compared pretreatment values.Both drugs have nearly the same effects on renal function presented by decreasing glomerular filtration rate (GFR) as indicated by elevating serum urea levels.Conclusion: The selectivity of COX2 inhibition is not the major character that could be correlated with cardiovascular events related to their administration.Since, meloxicam could aggravate some cardiovascular risk factors more than celecoxib does, as presented a significant increment in serum CK activity.
PEMBERDAYAAN PEDAGANG PASAR KREMPYENG DI TENGAH PANDEMI COVID-19
Authors: Alliyah Siti , Maslichan Maslichan 
Published: April 2022

The Covid-19 pandemic that has hit all countries since the beginning of 2020 has caused all sectors of life, especially the economy, to experience a very large impact. In connection with the existence of WFH and social distancing, the movement of the community in life is slow because with WFH people cannot leave the house and with social distancing people are prohibited from carrying out activities that are gathering or grouping. Rembang city is one of the areas in Central Java which is included in the red zone, because of the presence of several people who were positive for the Covid-19 virus. So that people also do WFH and social distancing. One of the villages that experienced the impact of WFH and social distancing is Jolotundo village. One of the community activities affected by the covid-19 virus is the activity of the Jolotundo village community “pasar krempyeng”. So that the STIE YPPI Rembang service team is motivated to solve partner problems, where the focus of our activities is so that the “pasar krempyeng” trader group has a new business, where the new business can be carried out both on the production and marketing side. Methods of implementing activities that have been carried out include: counseling, management training and practice of making herbal medicine. The results of community service activities in Jolotundo village, including; There are group participants who open a new business (herbal drink), there is an attractive packaging that supports the marketing program.
EDITORIAL OPINION: VALUE WITHIN THE PROSTHETIC AND ORTHOTIC PROVISION PROCESS
Authors: Raschke Silvia Ursula 
Published: April 2022

This Editorial presents an overview of the uptake of clinical outcome measures in the prosthetics and orthotics sector and considers how the use of objective measures contribute to demonstrating value provided. A decade ago, payors began to demand objective data to document costs vs. benefits from prosthetic and orthotic providers. The speed with which the sector responded to help develop measures and to begin to integrate them into practice is remarkable. This suggests an encouraging resilience and ability to adapt on the part of the sector as other trends such as Values-Based Health Care emerge to challenge the sector.
Article PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/38442/29321
How To Cite: Raschke S.U. Editorial opinion: value within the prosthetic and orthotic provision process. Canadian Prosthetics & Orthotics Journal. 2022; Volume 5, Issue 1, No.9. https://doi.org/10.33137/cpoj.v5i1.38442
Corresponding Author: Silvia Ursula Raschke, PhDBritish Columbia Institute of Technology (BCIT), 3700 Willingdon Avenue, Burnaby, British Columbia, Canada.E-Mail: Silvia_Raschke@bcit.caORCID ID: https://orcid.org/0000-0001-7964-4295
Effectiveness of manual therapies versus surgical decompression in hand function in women with carpal tunnel syndrome: a systematic review
Authors: Carvalho Adriana Pontes , Fuzari Helen Kerlen Bastos , Barros Manuella Moraes Monteiro Barbosa , Souza Fernando Henrique Moraes de , Bernardino Silvya Nery , Oliveira Daniella Araújo de 
Published: April 2022

Purpose: To assess the quality of evidence for the efficacy of manual therapy in improving hand function in relation to surgical decompression in women with CTS. Methodology: Seven electronic databases were searched to identify randomized controlled trials that compared the efficacy of exclusive manual therapies and surgical decompression in improving hand function in women with carpal tunnel syndrome. Quality assessment was conducted using the Cochrane risk of bias tool. The study was registered in PROSPERO under number CRD42018084250. Results: Two trials were identified and included in the review. The results of critical appraisal of quality was low risk of bias. Conclusion: Evidence suggest that manual therapy may have similarly effective in relation to surgery decompression in improving hand function in women with carpal tunnel syndrome. Future trials must assess the efficacy of manual therapies in different numbers of session looking for better results.
ANALISIS DESAIN KARAKTER MAKHLUK FOLKLORE DARI JEPANG DALAM BUKU CERITA ANAK BERGAMBAR
Authors: Tjoantara Angelica Naomi , Ratri Dianing , Maslan Riama 
Published: April 2022

AbstrakIndonesia memiliki berbagai jenis makhluk mitologi dalam cerita rakyat yang merupakan bagian dari budaya Indonesia. Karakter makhluk mitologi ini kerap diceritakan dalam cerita rakyat yang sampai sekarang diadaptasi menjadi berbagai format kontemporer salah satunya ke dalam buku cerita anak. Namun, pengaplikasian karakter dalam cerita rakyat tersebut cenderung kuno dan monoton dari buku satu ke buku lainnya. Sebagai perbandingannya, Jepang yang juga memiliki berbagai macam karakter budaya dalam cerita rakyatnya dapat mengadaptasi karakter makhluk mitologi tersebut ke dalam cerita dengan tema yang lebih kontemporer. Untuk itu, penulis melakukan kajian mengenai desain karakter makhluk folklore dalam buku cerita anak Jepang yang memuat tema kontemporer. Tujuan penelitian ini adalah untuk mengidentifikasi dan memahami elemen dalam membangun desain karakter berdasarkan makhluk mitologi dan membuat suatu konsep berdasarkan hal tersebut. Penelitian menggunakan metode kualitatif dengan pendekatan studi kasus karakter desain dalam buku anak Jepang dengan tema folklore kontemporer. Kemudian peneliti membandingkan dengan desain referensi aslinya menggunakan teori manga matriks dan RWD (Ruang, Waktu, Datar). Hasil dari penelitian ini kemudian dapat digunakan sebagai acuan bagi ilustrator maupun penulis cerita untuk lebih menggunakan karakter dari tradisi dan budaya Indonesia ke dalam bentuk cerita sebagai salah satu upaya pelestarian budaya dan cerita rakyat di Indonesia. Kata Kunci: desain karakter, buku bergambar, cerita rakyat kontemporer, makhluk mitologi AbstractIndonesia has varieties of mythological creatures based on the local Indonesian folktales. Nowadays these characters are often introduced inside stories, games, or other contemporary media and one of them is children’s picture books. Sadly, the implementation of these cultural characters were monotonous and redundant from one book to another. As a case study, Japan has similar cultures regarding folktale with Indonesia and has implemented the essence of those characters into more contemporary themed stories. From these findings, the writer delivered qualitative research to study Japanese picture book’s character designs with contemporary themes. The purpose of this research is to identify and understand the elements in building character designs based on mythological creatures and create a concept based on them. The research uses a qualitative method with a case study approach to character designs in Japanese children's books with the theme of contemporary folklore. Then the researcher compared it with the original reference design using matrix manga theory and RWD. Findings from this research may be used as reference for both Indonesian writer and illustrator to create stories and designs based on Indonesian’s characters from folktales as a way to preserve Indonesian’s folktales. Keywords: character design, contemporary folktale, mythological creature, picture book
Electronic, Magnetic, and Optical Performances of Non-Metals Doped Silicon Carbide
Authors: Zhang Lin , Cui Zhen 
Published: April 2022

The configurations of nine different non-metals doped silicon carbide (NM-SiC) were structured by using the density functional theory (DFT). The magnetic, electronic, and optical properties of each NM-SiC are investigated at the most stable structure with the maximum binding energy. Although the O-, Si-, and S-SiC systems are still non-magnetic semiconductors, the N- and P-SiC systems have the properties of the magnetic semiconductors. The H-, F-, and Cl-SiC systems exhibit the half-metal behaviors, while the B-SiC system converts to magnetic metal. The redistribution of charges occurs between non-metals atoms and adjacent C atoms. For the same doping position, the more charges are transferred, the greater the binding energy of the NM-SiC system. The work function of the NM-SiC systems is also adjusted by the doping of NM atoms, and achieves the minimum 3.70 eV in the P-SiC, just 77.1% of the original SiC. The absorption spectrum of the NM-SiC systems occurs red-shift in the ultraviolet light region, accompanying the decrease of absorption coefficient. These adjustable magnetic, electronic, and optical performances of NM-SiC expand the application fields of two-dimensional (2D) SiC, especially in designing field emission and spintronics devices.
Renal Function Mediates the Association Between Klotho and Congestive Heart Failure Among Middle-Aged and Older Individuals
Authors: Zhu Xu , Lu Xinyi , Yin Ting , Zhu Qingqing , Shi Shi , Cheang Iokfai , Yue Xin , Tang Yuan , Liao Shengen , Zhou Yanli , Zhang Haifeng , Li Xinli , Yao Wenming 
Published: April 2022

ObjectiveUsing a newly released National Health and Nutrition Examination Survey (NHANES) data of serum Klotho, this study aimed to explore the relationship between Klotho and specific cardiovascular diseases (CVD), as well as the mediation effect of renal function, among middle-aged and older individuals within the general population.MethodsThis nationally representative cross-sectional study analyzed data from the 2007–2016 NHANES. A total of 13,765 participants, who aged 40 years or older, from the general population were examined. Klotho were divided into four groups based on median and interquartile range. The associations among Klotho (exposure), congestive heart failure (CHF; outcome), and renal function markers [estimated glomerular filtration rate (eGFR), blood urea nitrogen (BUN), uric acid (UA), and urine albumin-to-creatinine ratio (UACR); mediators] were investigated using mediation analysis.ResultsIn comparison to the lowest quartile, Klotho in the highest quartile was independently associated with the prevalence of CHF (OR 0.59; 95% CI 0.46–0.77, p for trend = 0.001), but not with other individual CVDs. Klotho had a significant direct effect on the prevalence of CHF (all p &lt; 0.001), while eGFR, BUN, UA, and UACR partly mediated the indirect effect of Klotho on the prevalence of CHF (all p &lt; 0.05), explaining 19.51, 6.98, 13.93, and 0.71% of the association between Klotho and CHF, respectively. Additionally, restricted cubic spline regression demonstrated a linear association and negative correlation between Klotho level and CHF.ConclusionThese findings suggest that Klotho is closely linked to CHF and renal function may be a key mediator of this association.
Association Between Left Ventricular Geometry and Renal Outcomes in Patients With Chronic Kidney Disease: Findings From Korean Cohort Study for Outcomes in Patients With Chronic Kidney Disease Study
Authors: Suh Sang Heon , Oh Tae Ryom , Choi Hong Sang , Kim Chang Seong , Bae Eun Hui , Oh Kook-Hwan , Lee Joongyub , Jung Ji Yong , Lee Kyu-Beck , Ma Seong Kwon , Kim Soo Wan 
Published: April 2022

BackgroundThe impact of left ventricular (LV) geometry on the renal outcomes in patients with chronic kidney disease (CKD) has not been established yet. We aimed to investigate the association of LV geometry with renal outcomes and all-cause mortality in patients with pre-dialysis CKD.MethodsA total of 2,144 subjects from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD) were categorized by LV geometry, which was defined by LV mass index and relative wall thickness [normal geometry, concentric remodeling, eccentric hypertrophy (eLVH), and concentric hypertrophy (cLVH)]. Study outcomes were composite renal events [decline of kidney function (the first occurrence of &gt; 50% decline of eGFR or doubling of serum creatinine from the baseline) and onset of ESRD (initiation of dialysis or kidney transplantation) during follow-up periods)] and all-cause mortality.ResultsCox regression analysis revealed that eLVH [adjusted hazard ratio (HR) 1.498, 95% confidence interval (CI) 1.197–1.873] and cLVH (adjusted HR 1.289, 95% CI 1.011–1.643) were associated with increased risk of composite renal events, whereas concentric remodeling (adjusted HR 1.881, 95% CI 1.135–3.118) and cLVH (adjusted HR 2.216, 95% CI 1.341–3.664) were associated with increased risk of all-cause mortality. Sensitivity analyses confirmed that concentric remodeling (adjusted HR 1.993, 95% CI 1.197–3.368) and eLVH (adjusted HR 1.588, 95% CI 1.261–2.001) are independently associated with all-cause mortality and composite renal events, respectively.ConclusionIn conclusion, we report that LV geometry is significantly associated with adverse renal outcomes and all-cause mortality in patients with pre-dialysis CKD. Echocardiographic determination of LV geometry may help the early identification for the patients with high risk of CKD progression.
Discovery of Potential Biomarkers for Postmenopausal Osteoporosis Based on Untargeted GC/LC-MS
Authors: Kou Jun , He Chunyang , Cui Lin , Zhang Zhengping , Wang Wei , Tan Li , Liu Da , Zheng Wei , Gu Wei , Xia Ning 
Published: April 2022

PurposeAs an important public health problem, osteoporosis (OP) in China is also in an upward trend year by year. As a standard method for diagnosing OP, dual-energy X-ray absorptiometry (DXA) cannot analyze the pathological process but only see the results. It is difficult to evaluate the early diagnosis of OP. Our study was carried out through a serum metabolomic study of OP in Chinese postmenopausal women on untargeted gas chromatography (GC)/liquid chromatography (LC)–mass spectrometry (MS) to find possible diagnostic markers.Materials and Methods50 Chinese postmenopausal women with osteoporosis and 50 age-matched women were selected as normal controls. We first used untargeted GC/LC-MS to analyze the serum of these participants and then combined it with a large number of multivariate statistical analyses to analyze the data. Finally, based on a multidimensional analysis of the metabolites, the most critical metabolites were considered to be biomarkers of OP in postmenopausal women. Further, biomarkers identified relevant metabolic pathways, followed by a map of metabolic pathways found in the database.ResultsWe found that there may be metabolic pathway disorders like glucose metabolism, lipid metabolism, and amino acid metabolism in postmenopausal women with OP. 18 differential metabolites are considered to be potential biomarkers of OP in postmenopausal women which are a major factor in metabolism and bone physiological function.ConclusionThese findings can be applied to clinical work through further validation studies. It also shows that metabonomic analysis has great potential in the application of early diagnosis and recurrence monitoring in postmenopausal OP women.
Efficacy and Safety of Eldecalcitol for Osteoporosis: A Meta-Analysis of Randomized Controlled Trials
Authors: Liu Hongyan , Wang Guoqi , Wu Ting , Mu Yiming , Gu Weijun 
Published: April 2022

ObjectEldecalcitol (ED-71) is a vitamin D analog for the treatment of osteoporosis. However, inconsistent results have been reported in this regard. Hence, this meta-analysis of randomized controlled trials (RCTs) aimed to assess the efficacy and safety of ED-71 for osteoporosis.MethodsThe PubMed, Embase, and the Cochrane Library databases were systematically searched to identify potential trials from inception until April 2021. The investigated outcomes included bone mineral density and fractures at various sites, and potential adverse events. The pooled effect estimates were calculated using weighted mean difference (WMD) and relative risk (RR) with 95% confidence interval (CI) using the random-effects model.ResultsEight RCTs involving 2368 patients were selected for the final meta-analysis. The pooled results showed that ED-71 were associated with a higher level of femoral neck (FN) bone mineral density (BMD) (WMD: 0.92; 95% CI: 0.24–1.60; P = 0.008), while it had no significant effect on lumbar spine BMD (WMD: 1.09; 95% CI: –0.11 to 2.30; P = 0.076) and hip BMD (WMD: 1.12; 95% CI: –0.16 to 2.40; P = 0.088). Moreover, the use of ED-71 could protect against the risk of all osteoporotic fracture (RR: 0.70; 95% CI: 0.55–0.88; P = 0.003) and vertebral fracture (RR: 0.74; 95% CI: 0.55–0.98; P = 0.038), while it did not affect the risk of nonvertebral fracture (RR: 0.53; 95%CI: 0.23–1.23; P = 0.140). The subgroup analyses found that the effects of ED-71 were superior to those of alfacalcidol on both BMD and fracture results. Moreover, the use of ED-71 plus bisphosphonate was associated with a greater improvement in BMD at various sites compared with bisphosphonate alone. Finally, ED-71 was associated with an increased risk of increased urine calcium level (RR: 1.69; 95% CI: 1.33–2.15; P &lt; 0.001).ConclusionThis study found that the use of ED-71 could improve BMD and fractures at various sites, especially compared with alfacalcidol or a combination with bisphosphonate for patients with osteoporosis.Systematic Review Registration[http://www.crd.york.ac.uk/prospero], identifier [CRD42021270536].
Impacts of Nontuberculous Mycobacteria Isolates in Non-cystic Fibrosis Bronchiectasis: A 16-Year Cohort Study in Taiwan
Authors: Lin Chun-Yu , Huang Hung-Yu , Hsieh Meng-Heng , Fang Yueh-Fu , Lo Yu-Lun , Lin Shu-Min , Huang Yu-Tung , Yeh Chih-Hsin , Wang Chun-Hua , Lin Horng-Chyuan 
Published: April 2022

BackgroundThe prevalence of nontuberculous mycobacteria (NTM) in patients with chronic respiratory disease has increased. The implication of NTM in non-CF bronchiectasis remained controversial. This study investigated the impact of NTM in non-CF bronchiectasis in Taiwan.MethodsClinical manifestation, imaging, and microbiological data were retrieved from the Chang Gung Research Database, the largest electronic medical record-based database in Taiwan. Patients with bronchiectasis during 2001–2016 were included. Cox proportional hazard model was employed to compare outcomes between patients with negative and positive NTM isolates after 1:1 propensity score matching.ResultsA total of 19,647 non-CF bronchiectasis patients were enrolled and 11,492 patients were eligible for analysis after exclusion screening. Finally, patients with negative and positive NTM isolates—650 each—were analyzed after propensity score matching. The patients with negative NTM isolates were divided into three groups: Pseudomonas aeruginosa isolates (n = 53); fungus isolates (n = 26); and concomitant P. aeruginosa and fungus isolates (n = 8). The patients with positive NTM isolates were divided into five groups: single NTM isolate (n = 458); multiple NTM isolates (n = 60); concomitant NTM and P. aeruginosa isolates (n = 89); concomitant NTM and fungus isolates (n = 33); and concomitant NTM, P. aeruginosa, and fungus isolates (n = 10). Patients with P. aeruginosa isolates; concomitant NTM and P. aeruginosa isolates; concomitant NTM, P. aeruginosa, and fungus isolates had independently associated with respiratory failure and death. Patients with single or multiple NTM isolates were not related to ventilator use, but both were independent risk factor for mortality.ConclusionNTM, either combined with P. aeruginosa or fungus, exhibited more frequent exacerbations in non-CF bronchiectasis patients. Moreover, NTM predicted mortality in non-CF bronchiectasis patients and were also correlated to respiratory failure while concomitantly isolated with P. aeruginosa and fungus.