bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconfigurable Negative Bit Line Collapsed Supply Write Assist for 9T-ST SRAM Cell
Authors: Ganesh Chokkakula , Murthy K. S.N. 
Published: April 2022

Abstract
This paper presents a Reconfigurable Negative Bit Line Collapsed Supply (RNBLCS) write driver circuit for the 9T Schmitt Trigger-based SRAM Cell (9T-ST), significantly improving write performance for real-time memory applications. In deep sub-micron technology, increasing device parameter deviations significantly reduce SRAM cells' write-ability. The proposed RNBLCS write-assist driver for 9T-ST SRAM cell has 0.84×, 0.48×, 0.27× optimized write access delay and 1.05×, 1.08×, 1.19× improvement in Write Static Noise Margin (WSNM), 1.05×, 1.13×, and 1.39× improvement in Write Margin (WM), 0.96×, 0.89× and 0.72× minimum Write Trip-Point (WTP) from Transient-Negative Bit Line (Tran-NBL), capacitive Charge Sharing (CCS), and conventional write circuits respectively. The proposed RNBLCS is functionally verified using a Synopsys Custom compiler with a 16nm BSIM4 model card for bulk CMOS.
Neck Disability and Insomnia in Head and Neck Cancer Survivors
Authors: Harris Alexandria , Li Jinhong , MA Karley Atchison , Soose Ryan , Piva Sara R. , Imes Christopher C. , Johnson Jonas T. , Nilsen Marci L. 
Published: April 2022

Abstract
Purpose: Head and neck cancer (HNC) treatments often have a substantial long-term impact on physical appearance, psychological well-being, and physiologic functions. Our study examines the relationship between symptoms of neck disability and insomnia among post-treatment HNC survivors.Methods: Cross-sectional analysis of adult survivors of squamous cell cancer of the oral cavity, oropharynx, and larynx/hypopharynx treated at a single-center, university-affiliated HNC survivorship clinic between August 2018 and March 2021. The primary outcome is Insomnia Severity Index (ISI) score. Multivariable ordinal regression was used to analyze the association between neck disability index (NDI) scores and insomnia.Results: A total of 411 predominantly male(77.9%) survivors with an average age of 63.07±11.53 years, were included in the analysis. Primary cancer sites were oropharynx(48.7%), oral cavity(28.0%), and larynx/hypopharynx(23.3%). Mean ISI and NDI scores were 7.09±6.66(range=0-28) and 8.83±8.06(range=0-38), respectively. After controlling for age, race, treatment modality, tumor site, tumor staging, and time since treatment, the odds of a survivor reporting insomnia was 8.65 times higher in those with mild neck disability(95% OR (4.31, 17.37), p<0.001) and 48.12 times higher in those with moderate to complete neck disability(95% OR (22.35, 103.58), p<0.001) when compared to those with no neck disabilityConclusions: The acute symptom burden of neck disability is shown to be highly associated with insomnia severity. HNC providers should address an array of symptoms for early diagnosis and intervention. Our results support the need for a multidisciplinary care model for post-treatment HNC survivors to facilitate screening, access and early intervention for survivor well-being.
Association of marital status with cognitive function in Chinese hypertensive patients: a cross-sectional study
Authors: shen si , Cheng Jianduan , Li Junpei , Xie Yanyou , Wang Li , Zhou Xinlei , Zhou Wei , Zhu Lingjuan , Wang Tao , Tu Jianglong , Bao Huihui , Cheng Xiaoshu 
Published: April 2022

Abstract
Purpose
The aim of this study was to evaluate the association of marital status with cognitive function, and to examine the potential effect modifiers in Chinese hypertensive populations.
Methods
A total of 9,525 adult Chinese hypertensive patients were enrolled in this cross-sectional study. Cognitive function as the dependent variable in our study was assessed by the version of the Mini-Mental State Examination (MMSE). We adjusted for potential confounding factors in multiple linear regression models to examine the relationship of marital status with cognitive function. In addition, we divided the population according to gender to explored whether there was a gender-specific differences.
Results
Among the 9,525 study participants, the mean (SD) age of males was 63.5 (10.3) years and mean MMSE was 24.9 ± 5.0, whereas in females the mean (SD) age was 63.8 (9.3) years and mean MMSE was 19.4 ± 6.4. Non-married person had lower score of MMSE, as well as lower subscore in each of the cognitive domains. A stronger correlation between marital status and lower MMSE score was statistically significant in men (non-married: β = -1.55; 95% CI: -1.89, -1.21) but not women (non-married: β = -0.22; 95% CI: -0.56, 0.12; p interaction = 0.006). Compared to participants in widowed and divorced status, never married men was more likely to have lower score of MMSE (β = -2.30, 95% CI -3.10 ,- 1.50; p < 0.001).
Conclusions
Our study demonstrated that non-married status as an extremely important but prone to be neglected social risk factor for cognitive function. Gender was a strong effect modifiers: Being non-married was correlated with a higher risk of cognitive decline compared to being married in Chinese hypertensive men, especially among older men, but not women. Moreover, never married men showed poorer cognitive function than those who were divorced or widowed.
A Novel Prognostic Model Based on N6-Methyladenosine Regulators Predicts the Prognosis of Acute Myeloid Leukemia
Authors: Wang Li , Zhou Guangyu , Zhu Yu , Xiao Han , Cai Duo 
Published: April 2022

Abstract
Little is known about the role of N6-methyladenosine (m6A) RNA methylation in the pathogenesis of acute myeloid leukemia (AML). We identified m6A regulators as independent prognostic factors in AML and constructed a prognostic model based on m6A regulators. We performed differential analysis, functional enrichment analysis and protein-protein interaction relationships of the TCGA-LAML cohort. The relationship between m6A methylation and AML was demonstrated by copy number variation, methylation and co-expression analyses. Pathway activity and drug sensitivity analysis revealed possible pathogenic mechanisms of m6A in pan-cancer. Our study elucidates the important role of m6A regulators in the clinical prognosis of AML, and a prognostic model based on m6A regulators can accurately predict overall survival in AML patients.
Controlled release of vitamin D 3 using a nanocellulose-based membrane
Authors: Colturato Pedro L. , Goveia Danielle 
Published: April 2022

Abstract
Background
Epidemiological studies show that a significant fraction of the global population presents low levels of vitamin D3. In order to address this problem, one way to administer the vitamin is to incorporate it in novel drug delivery systems, such as transdermal devices. A possible substance for this purpose is cellulose, which has a long history of use in the health area. However, the application of nanostructured cellulose membranes, as local drug delivery systems, remains a challenge.
Objective
To develop a crystalline nanocellulose membrane as a new tool for the release of vitamin D3.
Methods
A new nanostructured membrane containing nanocellulose extracted from cotton linter and vitamin D3 was produced using the “casting” technique. The membrane was characterized using high-resolution scanning electron microscopy (FEG-SEM) and Fourier transform infrared spectroscopy (FT-IR). The kinetics of vitamin release was quantified using molecular spectroscopy (UV-Vis).
Results
The FT-IR spectra showed the presence of all the active components in the membrane sample, without structural alterations or the formation of new bonds. The FEG-SEM images showed the presence of vitamin crystals on the surface and in the interior of the membrane. The release of vitamin D3 occurred in a sustained manner, obtaining 3,029 IU mL-1 of vitamin D3 in 60 min.
Conclusions
The findings demonstrated that the membrane could be used for the sustained release of vitamin D3. This new biomaterial has potential as a new model for vitamin supplementation in individuals with vitamin D3 deficiency.
Development and characterization of novelly grown fire-resistant fungal fibers
Authors: Zhang Xijin , Li Yanjun , Fan Xudong , Wnek Gary , Liao Ya-Ting T. , Yu Xiong 
Published: April 2022

Abstract
This study conducted a comprehensive characterization and analyses on the fire-resistant behaviors of novel fungal fibers grown with substrate containing Silica (Si) source at multiple scales. At micro-scale, the results of SEM showed that silica affected the physiological activities of fungi, with the extent of effects depending upon its concentration. Fourier-transform infrared (FTIR) spectra displayed the existence of Si-O-C chemical bonds in fungal fibers grown with Si source, indicating that Si source becomes a part of the structure of fungal fibers. Thermogravimetric analysis (TGA) and Microscale combustion calorimetry (MCC) of fungal fibers exhibit an early thermal decomposition of non-combustible components, which will potentially help release the thermal stress and mitigation of spalling when used in concrete. Compared with polypropylene (PP) fibers, fungal fibers have a lower thermal degradation rate, a higher residual weight, a lower heat release peak temperature, and less total heat of combustion; all of these indicate improved thermal stability and fire resistance, and a lower rate of function loss in case of a fire. Additionally, the thermal stability and fire resistance of fungal fibers were improved with the increase of Si source concentration in the nutrition medium. For example, addition of 2% Si source in the feeding substrate leads to a 23.21% increase in residual weight in TGA, and a 23.66 W/g decrease in peak heat release rate as well as a 2.44 kJ/g reduction in total heat of combustion in MCC. At laboratory scale, compared with PP fibers, fungal fibers grown with 2% Si source have a higher residual weight of 40.40%, a higher ignition temperature of 200.50°C, and a declined flame height of 11.64 mm in real fire scenarios. Furthermore, only in the fungal fibers grown with Si source, partial burning occurred. In post-fire conditions, the microstructure of residual char from fungal fibers grown with higher content of Si source became denser, which would lead to a reduction of the fuel vapor release and heat transfer. FTIR spectra of residual char demonstrated that fungal fibers grown with Si source formed more stable chemical bonds with higher heat of chemical bond formation, contributing to improved thermal stability and fire resistance. Therefore, compared with traditional fibers used for fiber reinforced concrete, incorporating the new natural grown fiber will potentially further improve the fire resistance of concrete and mitigate the concrete spalling.
Organic farming of cotton Gossypium hirsutum L. mediates species richness and evenness of generalist predators
Authors: Shahid Muhammad , Razaq Muhammad , Farooq Muhammad Omer , Adnan Muhammad , Zahid Shayan , Hussain Altaf 
Published: April 2022

Abstract
Organic farming is known to enhance the diversity and abundance of biological control agents thus, complements integrated pest management (IPM). There is little published literature from cotton crop grown organically with respect to abundance and diversity of natural enemies. In this study we present the assemblage of arthropods predatory communities from the organically as well as conventionally grown cotton. We noted two Coccinellids species (Coccinella undecimpunctata L., Coccinella septempunctata L.), Formicid, Orius insidious (Say), two spider species (Thomisidae and Araneidae) and Encarsia formosa Gahan in both kinds of fields, but their populations and diversity were more abundant in organically managed fields. In organic cotton, species richness was significantly higher and Simpson dominance was significantly lower compared to conventional counterpart in 2019 and reverse situation was observed in 2021. Moreover, Chrysoperla carnea (Stephen) were observed only in organically grown cotton. Spiders and formicids first appeared almost at the same time when hemipetran pests were recorded. This study demonstrates that organically grown cotton fosters more densities of biological control agents and their species. Our results proved that pest management is triggered by two phenomena in organic farming. First, pest densities are reduced by the number of natural enemy species (species richness) when dominance is lower, and secondly, by the limited number of dominant species present in organic fields when species richness is lower. We also discuss implications of our results for pest management on organically grown cotton in the context of ecosystem services.
Molecular Characterization and Heterotic Grouping of Traditional Assam Rice (Oryza sativa L.)
Authors: Kumar Praveen , Sarma Debojit , Devi Laishram Monalisha , Bordoloi Dibosh , Barua P. K. , reddy Bodeddula Jayashankar 
Published: April 2022

Abstract
Parents of heterotic hybrids belong to different heterotic groups with high genetic divergence. Classification of traditional Assam rice germplasm in different pools would maximize the heterosis and ensure food security for over 35 million people. In the present investigation, 53 polymorphic markers detected 133 alleles across 60 upland rice genotypes of Assam, with an average of 2.5 alleles per marker. RM293 having the highest PIC value of 0.655, was the most appropriate marker for discriminating among genotypes. The genetic divergence using the Unweighted Neighbour-Joining (UNJ) method grouped the 60 genotypes into three major clusters. The eleven most divergent genotypes were subject to diallel analysis following Model 1 Method II of Griffing (1956) for combining ability and heterosis estimates. Lack of correlation between heterosis and genetic distance could be attributable to using a subset of markers not linked to yield or concerned. In genetic distance based heterotic grouping, the intra-group hybrids registered a higher frequency of crosses in concurrence with high values of grain yield per plant, specific combining ability effect, mid-parent heterosis, better-parent heterosis and standard heterosis than those of inter-group hybrids. An extensive choice of parents possessing attractive traits constellation would lead to increased yield of the hybrids with much better complementation and thus, needs emphasis together with a substantial hereditary distance for augmentation of yield heterosis.
Chemical hypermethioninemia in young mice: oxidative damage and reduction of antioxidant enzyme activity in brain, kidney, and liver
Authors: Meine Bernardo Moraes , Franceschi Thaís Scolari , Bona Natália Pontes , Spohr Luiza , Pedra Nathalia Stark , Spanevello Roselia Maria , de Aguiar Mayara Sandrielly Soares , Stefanello Francieli Moro 
Published: April 2022

Abstract
High levels of methionine (Met) and its metabolites, such as methionine sulfoxide (MetO), found in hypermethioninemia, can be detrimental to the body; however, the underlying mechanisms are still uncertain. Using a recently standardized protocol, the aim of this study was to investigate the effects of chronic administration of Met and/or MetO on parameters of oxidative damage in the total brain, liver, and kidney of young mice. Swiss male mice were subcutaneously injected with Met and MetO at concentrations of 0.35–1.2 g/kg body weight and 0.09–0.3 g/kg body weight, respectively, from the 10th − 38th day post-birth, while the control group was treated with saline solution. Results showed that Met and/or MetO caused an increase in reactive oxygen species (ROS) and lipoperoxidation, along with a reduction of superoxide dismutase (SOD) and catalase (CAT) activities in the brain. In the liver, Met and/or MetO enhanced ROS and nitrite levels, and reduced SOD, CAT, and delta aminolevulinic dehydratase activities. The effects on the kidney were an increase in ROS production and SOD activity, and a reduction in thiol content and CAT activity. These data demonstrated the contribution of redox imbalance to the systemic changes found in patients with hypermethioninemia. In conclusion, our findings may help future studies to better understand the pathophysiological mechanisms of hypermethioninemia as well as contribute to the search for new therapeutic agents for this pathology.
Variability in cadmium uptake in common wheat: impact of genetic variation and silicon supplementation
Authors: Yang Rui , LIANG XI , Strawn Daniel 
Published: April 2022

Abstract
Purpose To decrease the transfer of cadmium (Cd) to the food chain, it is essential to select wheat (Triticum aestivum L.) germplasm that accumulates the least amount of Cd and to develop management practices that promote a reduction in Cd uptake. This requires knowledge of factors controlling Cd accumulation in wheat plants, which are not fully understood. The aim of this study was thus to investigate variations in Cd accumulation, translocation, and subcellular distribution in response to supplemental Si in two wheat cultivars that have different Cd accumulation capacities. Methods Cd uptake and distribution in two common wheat cultivars, high-Cd ‘LCS Star’ and low-Cd ‘UI Platinum’ were evaluated at two levels of Cd (0 and 50 µM) and Si (0 and 1.5 mM) in a hydroponic experiment.Results LCS Star and UI Platinum were not different in root Cd accumulation but differed in Cd concentration in the shoot, which agreed with the variation between the two cultivars in their subcellular Cd distributions (i.e., cell wall and organelle and soluble fractions) as well as induced glutathione synthesis in response to Cd addition. Supplemental Si reduced Cd uptake and accumulation and suppressed Cd-induced glutathione synthesis.Conclusions The differences between the wheat cultivars in Cd accumulation in shoot mainly derive from root-to-shoot translocation, which is related to subcellular Cd distribution and Cd-induced glutathione synthesis. Exogeneous Si could decrease Cd translocation from root to shoot to alleviate Cd toxicity in common wheat.
Research on cooperative adaptive cruise control(CACC) system of heavy duty vehicle platooning
Authors: Ou jian , Han Xiansheng , Huang Dong , Wu Pengfei , Deng Guohong , Zhang Yong 
Published: April 2022

Abstract
To improve the highway congestion and low road transportation efficiency, heavy duty vehicle platooning driving in formation can improve the expressway in this paper. Firstly, a heavy duty vehicle longitudinal dynamic model and an inverse longitudinal dynamic model is established, an inverse engine model based on centroid moment of inertia balance is proposed for heavy duty vehicle platooning. Secondly, the distance between the front and rear vehicles, speed, acceleration and other relevant parameters in the heavy duty vehicle platooning are used as the input state of the controller, the vehicle acceleration required to follow the vehicle is determined by the model predictive control algorithm. At the same time, the hierarchical control system is established by the model predictive control algorithm and optimize it. Both simulation verification and intelligent vehicle experiment results show that the optimized platooning controller has a better performance than the general controller. The stability and effectiveness of the platooning are improved by this control method.
WSdesign: A free design tool for generating uniform and functionally gradient/hybrid wave springs fabricated using additive manufacturing processes
Authors: Haq Muhammad Rizwan ul , Nazir Aamer , Azam Hamza , Jeng Jeng-Ywan 
Published: April 2022

Abstract
Design for additive manufacturing (DfAM) enables the design and fabrication of intricate but application-based functionally optimized geometries by reducing the manufacturing time. It also gave unlimited design freedom to alter any specific parameter and re-generate the design with improved mechanical properties. However, designing a complex and application-specific component needs comprehensive knowledge of drawing, intended usage, high expertise, and command on designing software with ample time. Mechanical springs e.g., wave springs of uniform/complex shaped designs consume a lot of manual hard work. A new design tool is developed for constructing wave springs of different morphologies with uniform or varying design parameters or the combination of both by successfully controlling the number of waves per coil, coil diameter, geometric shape, thickness/width of the strip, the diameter of the wire, wave height, overlap between coils, etc. In this methodology, a graphical user interface (GUI) was developed in which the user can select the type of wave spring which can be either uniform, functional gradient, or hybrid along with every parameter with the geometric as well as dimensional variation is defined through Python code. The code is directly run in Autodesk Fusion 360 software which is used to transform that code into a 3D model with all defined features and can be saved in different formats which can be directly printed. Several designs of uniform and functionally graded/hybrid as well as complex shaped wave springs were successfully designed and manufactured by fused deposition modeling (FDM), stereolithography (SLA), and powder bed fusion (MJF) technology with different materials which resulted in a good surface finish, smooth printability, and less dimensional variation. In addition to that, this method can prove its versatility to design complex wave springs for research as well as for industrial usage as per load requirements without having in-depth design expertise and spending much less time.
Switchable Fano resonance filter with graphene -based double free-standing dielectric gratings
Authors: Wang Zexiang , Shi Wenjie , Hu Zhengda , Wang Jicheng , Khakhomov Sergei , Semchenko Igor 
Published: April 2022

Abstract
Fano resonance is based on plasmonic metasurfaces and has many applications in all kinds of fields. In this paper, we propose an independently switchable double-layer raster structure based on graphene. Depending on the highly adjustable nature of graphene, the Fermi energy level can be adjusted to control the Fano resonance at different wavelengths. The equivalent resonator coupling mode method is used to simulate the Fano resonance, and the transmission spectrum fits well. Functional switch at different wavelengths can be achieved using Fano resonance technology. The simulation obtained a fantastic group refractive index of the designed structure, indicating that it there is a possibility to apply it in slow light. The effect of the environmental refractive index on sensing performance was studied and we found the structure has great potential in making high-sensitivity sensors. To sum up, it is hoped that this structure can make a great contribution to the manufacture of integrated optics.
Low Profile Intelligent Reflecting Metasurface for B5G Applications
Authors: Selvaraj Monisha , Vijay Ramya , Anbazhagan Rajesh 
Published: April 2022

Abstract
In this letter, an intelligent reflecting single-layer frequency selective metasurface is presented for beyond fifth-generation (B5G) applications. The proposed unit cell comprises of a novel complementary loop to achieve wider impedance bandwidth of 0.70 – 0.96 THz with high angular stability and better polarization insensitivity. The modified complementary loop structure is etched on a gold-layered polydimethylsiloxane substrate that displays a stable resonance frequency for possible incident angles. The reflecting unit cell with negative permeability has a peak reflection coefficient of -24.19 dB at 0.82 THz. Here, an equivalent circuit model is used to analyse a proposed FSS in the THz range.