bluuebunny/crossref_metadata_2025_split huggingface dataset:
Was size of healthcare institution a factor affecting changes in healthcare utilisation during the COVID-19 pandemic in Korea? A retrospective study design analysing national healthcare big data
Authors: Park Young-Taek , Lane Chris , Lee Hyun-Ji , Lee Jinhyung 
Published: December 2022

ObjectivesMany small-sized healthcare institutions play a critical role in communities by preventing infectious diseases. This study examines how they have been impacted by the global COVID-19 pandemic compared with large hospitals.DesignThis study adopted a retrospective study design looking back at the healthcare utilisation of medical facilities according to size after the COVID-19 pandemic. The dependent variable was change in the number of outpatient health insurance claims before and after onset of the COVID-19 pandemic. The independent variable was an observation time point of the year 2020 compared with 2019.Setting and participantsThe study was conducted in Korea having a competitive medical provision environment under the national health insurance system. The units of analysis are hospitals and clinics: tertiary hospitals (42), general hospitals (293), small hospitals (1272) and medical clinics (27 049). This study analysed all the health insurance claim data from 1 January 2019 to 31 December 2020.ResultsCompared with 2019, in 2020, there were significant decreases in the number of claims (−14.9%), particularly in small hospitals (−16.8%) and clinics (−16.3%), with smaller decreases in general hospitals (−8.9%) and tertiary hospitals (−5.3%). The reduction in healthcare utilisation increased as the size of institutions decreased. The magnitude of decrease was significantly greatest in small hospitals (absolute risk (AR): 0.8317, 0.7758 to 0.8915, p<0.0001; relative risk (RR): 0.8299, 0.7750 to 0.888, p<0.0001) followed by clinics (AR: 0.8369, 0.8262 to 0.8478, p<0.0001; RR: 0.8362, 0.8255 to 0.8470, p<0.0001) even after controlling institutional covariates.ConclusionThe external impact of the pandemic increased incrementally as the size of healthcare institutions decreased. Healthcare policy-makers need to keep in mind the possibility that small hospitals and clinics may experience reduced healthcare utilisation in the infectious disease pandemic. This fact has political implications for how healthcare policy-makers should prepare for the next infectious disease pandemic.
Prevalence of long COVID-19 among healthcare workers: a systematic review and meta-analysis protocol
Authors: Al-Oraibi Amani , Naidu Jatin Sridhar , Chaka Aasiya , Woolf Katherine , B Nellums Laura , Tarrant Carolyn , Pan Daniel , Sze Shirley , Martin Christopher A , Gogoi Mayuri , Nazareth Joshua , Pareek Manish 
Published: December 2022

IntroductionA proportion of those who survive the acute phase of COVID-19 experience prolonged symptoms, commonly known as long COVID-19. Given that healthcare workers (HCWs) face an elevated risk of acute COVID-19 compared with the general population, the global burden of long COVID-19 in HCWs is likely to be large; however, there is limited understanding of the prevalence of long COVID-19 in HCWs, or its symptoms and their clustering. This review will aim to estimate the pooled prevalence and the symptoms of long COVID-19 among HCWs infected with SARS-CoV-2 globally, and investigate differences by country, age, sex, ethnicity, vaccination status and occupation.Methods and analysisA systematic review and meta-analysis will be conducted. Medline (via Ovid), CINAHL (via EBSCO), Embase (via Ovid), PsycINFO (via EBSCO),OpenGrey(grey literature) andmedRxiv(preprint server) will be searched from the 31 December 2019 onward. All research studies and preprint articles reporting any primary data on the prevalence and/or the symptoms of long COVID-19 among adult HCWs will be included. Methodological quality will be assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data. Outcomes are anticipated to be the prevalence of long COVID-19 among HCWs around the world and trajectory of symptoms. Data synthesis will include random-effect meta-analysis for studies reporting prevalence data of long COVID-19 following SARS-CoV-2 infection among HCWs. The results will be presented with a 95% CI as an estimated effect across studies. Heterogeneity will be assessed using I² statistic. Where meta-analysis is inappropriate, a narrative synthesis of the evidence will be conducted.Ethics and disseminationEthical approval is not needed as data will be obtained from published articles. We will publish our findings in a peer-reviewed journal and disseminate the results of our review at conferences.PROSPERO registration numberCRD42022312781.
Efficacy of HEAR and HEART score to rule out major adverse cardiac events in patients presenting to the emergency department with chest pain: study protocol of the eCARE stepped-wedge randomised control trial
Authors: Moumneh Thomas , Penaloza Andrea , Charpentier Sandrine , Douillet Delphine , Prunier Fabrice , Riou Jérémie , Roy Pierre-Marie 
Published: December 2022

IntroductionCurrent guidelines for patients presenting to the emergency department (ED) with chest pain without ST-segment elevation myocardial infarction (STEMI) on ECG are based on serial troponin measurements. A clinical tool able to identify very low-risk patients who could forgo a troponin test and low-risk patients requiring only one troponin measurement would be of great interest. To do so, the HEAR and HEART score, standing for history, ECG, age, risk factors±troponin were prospectively assessed, but not combined and implemented in clinical practice. The objective of the eCARE study is to assess the impact of implementing a diagnostic strategy based on a HEAR score <2 or a HEART score <4 (HEAR-T strategy) to rule out non-STEMI without or with a single troponin measurement in patients presenting to the ED with chest pain without obvious diagnosis after physical examination and an ECG.Methods and analysisStepped-wedge cluster-randomised control trial in 10 EDs. Patients with non-traumatic chest pain and no formal diagnosis were included and followed for 30 days. In the interventional phase, the doctor will be asked not to perform a troponin test to look for an acute coronary if the HEAR score is <2 and not to perform an additional troponin test if the HEAR score is ≥2 and HEART score is <4. The main endpoint is the non-inferiority of the rates of major adverse cardiac events occurring between a patient’s discharge and the 30-day follow-up against current recommended guidelines.Ethics and disseminationThe study was approved by an institutional review board for all participating centres. If successful, the eCARE study will cover a gap in the evidence, proving that it is safe and efficient to rule out the hypothesis of an acute myocardial infarction in some selected very low-risk patients or based on a single troponin measurement in some low-risk patients.Trial registration numberNCT04157790.
Understanding the trends, and drivers of emigration, migration intention and non-migration of health workers from low-income and middle-income countries: protocol for a systematic review
Authors: Ikhurionan Paul , Kwarshak Yakubu Kevin , Agho Ekhosuehi T , Akhirevbulu Itua C G , Atat Josephine , Erhiawarie Franca , Gbejewoh Emmanuel O , Iwegim Chinelo , Nnawuihe Ukachi , Odogu Uyoyo , Okpere Jermaine , Omoyibo Efe E , Orikpete Efetobo Victor , Otakhoigbogie Uwaila , Ukueku Avwebo , Ugwi Patience , Wariri Oghenebrume 
Published: December 2022

IntroductionThe WHO estimates a shortage of 18 million health workers (HWs) by 2030, primarily in low-income and middle-income countries (LMICs). The perennial out-migration of HWs from LMICs, often to higher-income countries, further exacerbates the shortage. We propose a systematic review to understand the determinants of HWs out-migration, intention to migrate and non-migration from LMICs.Methods and analysisThis protocol was designed in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols guideline for the development and reporting of systematic review protocols. We will include English and French language primary studies (quantitative or qualitative) focused on any category of HWs; from any LMICs; assessed migration or intention to migrate; and reported any determinant of migration. A three-step search strategy that involves a search of one electronic database to refine the preliminary strategy, a full search of all included databases and reference list search of included full-text papers for additional articles will be employed. We will search Ovid MEDLINE, EMBASE, CINAHL, Global Health and Web of Science from inception to August 2022. The retrieved titles will be imported to EndNote and deduplicated. Two reviewers will independently screen all titles and abstract for eligibility using Rayyan. Risk of bias of the individual studies will be determined using the National Institute of Health study quality assessment tools for quantitative studies and the 10-item Critical Appraisal Skills Programme checklists for qualitative studies. The results will be presented in the form of narrative synthesis using a descriptive approachEthics and disseminationWe will not seek ethical approval from an institutional review board, as this is a systematic review. At completion, we will submit the report of this review to a peer-reviewed journal for publication. Key findings will be presented at local and international conferences.PROSPERO registration numberCRD42022334283.
Short-term dynamics of circulating tumor DNA predicting efficacy of sintilimab plus docetaxel in second-line treatment of advanced NSCLC: biomarker analysis from a single-arm, phase 2 trial
Authors: Han Xiao , Tang Xiaoyong , Zhu Hui , Zhu Dongyuan , Zhang Xiqin , Meng Xiangjiao , Hua Ying , Wang Zhongtang , Zhang Yan , Huang Wei , Wang Linlin , Yuan Shuanghu , Zhang Pinliang , Gong Heyi , Sun Yulan , Zhang Yingjie , Liu Zengjun , Dong Xiaomeng , Gai Fei , Huang Zhan , Zhu Changbin , Guo Jun , Wang Zhehai 
Published: December 2022

ObjectiveRobust biomarker predicting efficacy of immunotherapy is limited. Circulating tumor DNA (ctDNA) sought to effectively monitor therapeutic response as well as disease progression. This study aims to investigate predictive role of ctDNA short-term dynamic change (6 weeks postimmunotherapy) in a single-arm, phase 2 trial of sintilimab plus docetaxel for previously treated advanced non-small cell lung cancer (NSCLC) patients.MethodsA total of 33 patients with advanced NSCLC with disease progression during or after any first-line treatment were prospectively enrolled between 2019 and 2020. Patients received sintilimab (200 mg, day 1, every 3 weeks) plus docetaxel (75 mg/m2, day 3, every 3 weeks) for 4–6 cycles, followed by maintenance therapy with sintilimab (200 mg, day 1, every 3 weeks) until disease progression or unacceptable toxic effects. Blood samples were prospectively collected at baseline, and after 2 cycles of treatment (6 weeks post-treatment). All samples were subjected to targeted next-generation sequencing with a panel of 448 cancer-related genes. The landscape of high-frequency genomic profile of baseline and 6th week was described. Major molecular characteristics in preselected genes of interest associated with response to second-line chemoimmunotherapy were analyzed. The curative effects and prognosis of patients were evaluated.ResultsPatients with ctDNA clearance at 6th week had decreased tumor volume, while most patients with positive ctDNA at 6th-week experienced an increase in tumor volume. Positive 6th-week ctDNA was associated with significantly shorter progression-free survival (PFS) (91 vs NR days; p<0.0001) and overall survival (47 vs 467 days; p =0.0039). Clearance of clonal mutations and none new clonal formation at 6th week were associated with longer PFS (mPFS 89 vs 266 days, p =0.003). ctDNA clearance at 6th week was an independent risk factor for progression or death (HR=100 (95% CI 4.10 to 2503.00), p=0.005).ConclusionctDNA status and ctDNA mutation clearance putatively serve as predictive biomarkers for sintilimab combined with docetaxel chemotherapy in pretreated advanced NSCLC patients.
Silence of a dependence receptor CSF1R in colorectal cancer cells activates tumor-associated macrophages
Authors: Zhu Mingxuan , Bai Liangliang , Liu Xiaoxia , Peng Shaoyong , Xie Yumo , Bai Hong , Yu Huichuan , Wang Xiaolin , Yuan Ping , Ma Rui , Lin Jinxin , Wu Linping , Huang Meijin , Li Yingjie , Luo Yanxin 
Published: December 2022

BackgroundColony-stimulating factor 1 receptor (CSF1R), a classic tyrosine kinase receptor, has been identified as a proto-oncogene in multiple cancers. The CSF1/CSF1R axis is essential for the survival and differentiation of M2-phenotype tumor-associated macrophages (M2 TAMs). However, we found here that the CSF1R expression was abnormally down-regulated in colorectal cancer (CRC), and its biological functions and underlying mechanisms have become elusive in CRC progression.MethodsThe expression of class III receptor tyrosine kinases in CRC and normal intestinal mucosa was accessed using The Cancer Genome Atlas and Gene Expression Omnibus datasets and was further validated by our tested cohort. CSF1R was reconstructed in CRC cells to identify its biological functionsin vitroandin vivo. We compared CSF1R expression and methylation differences between CRC cells and macrophages. Furthermore, a co-culture system was used to mimic a competitive mechanism between CSF1R-overexpressed CRC cells and M2-like macrophages. We utilized a CSF1R inhibitor PLX3397 to ablate M2 TAMs and evaluated its efficacy on CRC treatment in animal models.ResultsWe found here that the CSF1R is silenced in CRC, and the reintroduced expression of the receptor in CRC cells can be cleaved by caspases and constrain tumor growthin vitroandin vivo, functioning as a tumor suppressor gene. We further identified CSF1R as a novel dependence receptor, which has the potential to act as either a tumor suppressor gene or an oncogene, depending on its activated state. In CRC tumors, CSF1R expression is enriched in TAMs, and its expression is associated with poor prognosis in patients ith CRC. In a co-culture system, CRC cells expressing CSF1R compete with M2-like macrophages for CSF1R ligands, resulting in a decrease in CSF1R activation and cell proliferation in macrophages. Blocking CSF1R by PLX3397 could deplete M2 TAMs and augments CD8+T cell infiltration, effectively inhibiting tumor growth and metastasis and improving responses to chemotherapy and immunotherapy.ConclusionOur findings revealed that CSF1R is a novel identified dependence receptor silenced in CRC. The silence abalienates its ligands to stimulate CSF1R expressed on M2 TAMs, which is an appealing therapeutic target for M2 TAM depletion and CRC treatment.
Black patients with cutaneous lupus are associated with positive family history of cutaneous lupus and systemic lupus
Authors: Keum Heejo , Brown L Steven , Chong Benjamin F 
Published: December 2022

ObjectivesVarious genetic polymorphisms have been associated with an increased risk of cutaneous lupus erythematosus (CLE). However, it is not fully known how often positive family histories occur in patients with CLE. The aims of this study are to determine the rate of positive family history among patients with CLE and to identify risk factors associated with positive family history.MethodsA retrospective cohort study was conducted among 338 patients with CLE seen in outpatient dermatology clinics in a tertiary referral centre in Dallas, Texas. The primary outcome was positive family history of CLE and/or SLE, as defined by the presence of self-reported CLE and/or SLE in first-degree or more distant relatives of a patient. Univariate analyses were performed to identify risk factors associated with positive family history of CLE and/or SLE in patients with CLE. Multivariable logistic regression analyses were performed to determine significant predictors of positive family history of CLE and/or SLE.Results34% (n=114) of patients reported positive family history of CLE and/or SLE. 7% (n=23) of patients with CLE had relatives with CLE, with 5% (n=18) having a first-degree relative with CLE. 30% (n=102) of patients with CLE had relatives with SLE, and 15% (n=52) had a first-degree relative with SLE. Black patients were more likely to have positive family history of CLE and/or SLE (OR 2.13, 95% CI 1.23 to 3.69, p=0.007).ConclusionsMore patients with CLE had positive family history of SLE than CLE. Black patients with CLE were more likely to have a relative with CLE and/or SLE. Providers can use this information to counsel patients with CLE on the risk of other family members having CLE and/or SLE. These data may help identify potentially new genetic polymorphisms associated with positive family history.
Long-term follow-up of certolizumab pegol in uveitis due to immune-mediated inflammatory diseases: multicentre study of 80 patients
Authors: Martín-Varillas José Luis , Sanchez-Bilbao Lara , Calvo-Río Vanesa , Adán Alfredo , Hernanz Inés , Gallego-Flores Adela , Beltran-Catalan Emma , Castro-Oreiro Sonia , Fanlo Patricia , Garcia Martos Alvaro , Torre Ignacio , Cordero-Coma Miguel , De Dios Juan Ramon , García-Aparicio Ángel , Hernández-Garfella Marisa , Sánchez-Andrade Amalia , García-Valle Andrea , Maiz Olga , Miguélez Roberto , Rodríguez-Montero Sergio , Urruticoechea Ana , Veroz Raúl , Conesa Arantxa , Fernández-Carballido Cristina , Jovaní Vega , Mondejar Jose J , Martínez González Olga , Moya Alvarado Patricia , Romero-Yuste Susana , Rubio-Muñoz Paula , Peña-Sainz-Pardo Eva , Garijo-Bufort Marta , Demetrio-Pablo Rosalía , Hernández José L , Blanco Ricardo 
Published: December 2022

ObjectivesTo evaluate effectiveness and safety of certolizumab pegol (CZP) in uveitis due to immune-mediated inflammatory diseases (IMID).MethodsMulticentre study of CZP-treated patients with IMID uveitis refractory to conventional immunosuppressant. Effectiveness was assessed through the following ocular parameters: best-corrected visual acuity, anterior chamber cells, vitritis, macular thickness and retinal vasculitis. These variables were compared between the baseline, and first week, first, third, sixth months, first and second year.ResultsWe studied 80 (33 men/47 women) patients (111 affected eyes) with a mean age of 41.6±11.7 years. The IMID included were: spondyloarthritis (n=43), Behçet’s disease (n=10), psoriatic arthritis (n=8), Crohn’s disease (n=4), sarcoidosis (n=2), juvenile idiopathic arthritis (n=1), reactive arthritis (n=1), rheumatoid arthritis (n=1), relapsing polychondritis (n=1),ConclusionsCZP seems to be effective and safe in uveitis related to different IMID, even in patients refractory to previous biological drugs.
Research on the electromagnetic and weak dipole moments of the tau-lepton at the Bestest Little Higgs Model
Authors: Cruz-Albaro E. , Gutiérrez-Rodríguez A. , Aranda J. I. , Ramírez-Zavaleta F. 
Published: December 2022

AbstractIn this paper, using the Bestest Little Higgs Model (BLHM) we calculate at the one-loop level the contributions to the Anomalous Magnetic Dipole Moment (AMDM) and Anomalous Weak Magnetic Dipole Moment (AWMDM) of the tau-lepton. The implications from this model are studied, emphasizing the contributions of the new physics induced by the new scalar and vector bosons of the BLHM:$$S_i=H_0, A_0, \phi ^{0}, \eta ^{0}, \sigma , H^{\pm }, \phi ^{\pm }, \eta ^{\pm }$$Si=H0,A0,ϕ0,η0,σ,H±,ϕ±,η±, and$$V_i=Z', W'^{\pm }$$Vi=Z′,W′±because these quantify the new physics. With these new contributions, we estimated bounds on the real and imaginary parts of the AMDM and AWMDM of the tau-lepton. Our study complements other one-loop-level research performed on models beyond the Standard Model.
The potential of Facebook advertising data for understanding flows of people from Ukraine to the European Union
Authors: Minora Umberto , Bosco Claudio , Iacus Stefano M. , Grubanov-Boskovic Sara , Sermi Francesco , Spyratos Spyridon 
Published: December 2022

AbstractThis work contributes to the discussion on how innovative data can support a fast crisis response. We use operational data from Facebook to gain useful insights on where people fleeing Ukraine following the Russian invasion are likely to be displaced, focusing on the European Union. In this context, it is extremely important to anticipate where these people are moving so that local and national authorities can better manage challenges related to their reception and integration. By means of the audience estimates provided by Facebook advertising platform, we analyse the flows of people fleeing Ukraine towards the European Union. At the fifth week since the beginning of the war, our results indicate an increase in the number of Ukrainian stocks derived from Ukrainian-speaking Facebook user estimates in all the European Union (EU) countries, with Poland registering the highest percentage share (33%) of the overall increase, followed by Germany (17%), and Czechia (15%). We assess the reliability of prewar Facebook estimates by comparison with official statistics on the Ukrainian diaspora, finding a strong correlation between the two data sources (Pearson’s $r=0.9$
r
=
0.9
, $p<0.0001$
p
<
0.0001
). We then compare our results with data on refugees in EU countries bordering Ukraine reported by the UNHCR, and we observe a similarity in their trend. In conclusion, we show how Facebook advertising data could offer timely insights on international mobility during crises, supporting initiatives aimed at providing humanitarian assistance to the displaced people, as well as local and national authorities to better manage their reception and integration.
Intercropping and Rhizobium Inoculation Affected Microclimate and Performance of Common Bean (Phaseolus vulgaris L.) Varieties
Authors: Shumet Shemeles Tesfaye , Ayalew Tewodros , Roro Amsalu Gobena , Beshir Hussien Mohammed 
Published: December 2022

A field experiment was carried out at Hawassa, during the 2020 cropping season with the objective to evaluate the impact of maize-common bean intercropping and Rhizobium inoculation on microclimate, growth, and yield of common bean varieties. Treatments consisting of two common bean varieties, two levels of inoculation and three spatial arrangements of common bean with another sole maize were laid out in a factorial arrangement in a randomized complete block design (RCBD) with three replications. The results revealed that the main effect of spatial arrangements highly significantly (

P

< 0.001) affected soil and leaf temperature. Soil moisture content was improved under intercropped plots compared with sole cropping. The intensity of light and qualities, such as red, far-red, and photosynthetically active radiations (μmol m−2 s−1) and ultraviolet rays (UV)-A, UV-B (W m−2), were reduced under intercropping as compared to the sole. Interaction effects of variety, spatial arrangements, and inoculation significantly (

P

< 0.01) affected plant height and leaf area index. Inoculated sole Nassir outperformed for plant height and leaf area index. Inoculated sole Hawassa Dume variety performed best for nodule number plant−1, nodule dry weight plant−1, pods number plant−1, 100 seed weight, grain yield, and above-ground biomass yield. The highest grain yield (2.8 t ha−1) was recorded from inoculated sole Hawassa Dume. However, considering the equivalent ratio (LER), intercropping with one maize row to two haricot bean rows spatial arrangements was productive by 62% more than sole cropping (total land equivalent ratio of 1.62%).