bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal associations between specific types of emotional reactivity and psychological, physical health, and school adjustment
Authors: Dollar Jessica M. , Perry Nicole B. , Calkins Susan D. , Shanahan Lilly , Keane Susan P. , Shriver Lenka , Wideman Laurie 
Published: January 2022

AbstractUsing a multimethod, multiinformant longitudinal design, we examined associations between specific forms of positive and negative emotional reactivity at age 5, children’s effortful control (EC), emotion regulation, and social skills at age 7, and adolescent functioning across psychological, academic, and physical health domains at ages 15/16 (N= 383). We examined how distinct components of childhood emotional reactivity directly and indirectly predict domain-specific forms of adolescent adjustment, thereby identifying developmental pathways between specific types of emotional reactivity and adjustment above and beyond the propensity to express other forms of emotional reactivity. Age 5 high-intensity positivity was associated with lower age 7 EC and more adolescent risk-taking; age 5 low-intensity positivity was associated with better age 7 EC and adolescent cardiovascular health, providing evidence for the heterogeneity of positive emotional reactivity. Indirect effects indicated that children’s age 7 social skills partially explain several associations between age 5 fear and anger reactivity and adolescent adjustment. Moreover, age 5 anger reactivity, low-, and high-intensity positivity were associated with adolescent adjustment via age 7 EC. The findings from this interdisciplinary, long-term longitudinal study have significant implications for prevention and intervention work aiming to understand the role of emotional reactivity in the etiology of adjustment and psychopathology.
Modeling Large‐Scale Heatwave by Incorporating Enhanced Urban Representation
Authors: Patel Pratiman , Jamshidi Sajad , Nadimpalli Raghu , Aliaga Daniel G. , Mills Gerald , Chen Fei , Demuzere Matthias , Niyogi Dev 
Published: January 2022

AbstractThis study evaluates the impact of land surface models (LSMs) and urban heterogeneity [using local climate zones (LCZs)] on air temperature simulated by the Weather Research and Forecasting model (WRF) during a regional extreme event. We simulated the 2017 heatwave over Europe considering four scenarios, using WRF coupled with two LSMs (i.e., Noah and Noah‐MP) with default land use/land cover (LULC) and with LCZs from the World Urban Database and Access Portal Tools (WUDAPT). The results showed that implementing the LCZs significantly improves the WRF simulations of the daily temperature regardless of the LSMs. Implementing the LCZs altered the surface energy balance partitioning in the simulations (i.e., the sensible heat flux was reduced and latent heat flux was increased) primarily due to a higher vegetation feedback in the LCZs. The changes in the surface flux translated into an increase in the simulated 2‐m relative humidity and 10‐m wind speed as well as changed air temperature within cities section and generated a temperature gradient that affected the temperatures beyond the urban regions. Despite these changes, the factor separation analysis indicated that the impact of LSM selection was more significant than the inclusion of LCZs. Interestingly, the lowest bias in temperature simulations was achieved when WRF was coupled with the Noah as the LSM and used WUDAPT as the LULC/urban representation.
Understanding the Excitation of Quasi‐6‐Day Waves in Both Hemispheres During the September 2019 Antarctic SSW
Authors: Ma Zheng , Gong Yun , Zhang Shaodong , Xiao Qiao , Xue Junwei , Huang Chunming , Huang Kaiming 
Published: January 2022

AbstractResponses of quasi‐6‐day waves (Q6DWs) to the extreme 2019 Antarctic stratospheric sudden warming (SSW) have been widely reported in the ionosphere, while the excitation mechanism of the global Q6DWs is still unclear in the mesosphere and lower thermosphere (MLT) region. According to the Aura satellite measurements, the amplitudes of the Q6DWs in the upper MLT region are found to be higher than their climatological activities from 2005 to 2020 at mid‐latitudes in both Northern and Southern Hemispheres. Combined with the Modern‐Era Retrospective Analysis for Research and Applications, version 2 data, the trigger mechanisms of the global enhanced Q6DWs are investigated by tracing their sources and propagations. Our analysis indicates that the equatorward propagation induced by the SSW is the main reason for the enhanced Q6DWs in the upper MLT at mid‐latitudes in the Southern Hemisphere, and the main source of the Q6DWs in the Northern Hemisphere is the seasonal variability. Besides, interhemispheric propagations also contribute to the amplification of Q6DWs during the 2019 Antarctic SSW.
Geometry and Segmentation of Cerberus Fossae, Mars: Implications for Marsquake Properties
Authors: Perrin C. , Jacob A. , Lucas A. , Myhill R. , Hauber E. , Batov A. , Gudkova T. , Rodriguez S. , Lognonné P. , Stevanović J. , Drilleau M. , Fuji N. 
Published: January 2022

AbstractThe NASA InSight mission to Mars successfully landed on 26 November 2018 in Elysium Planitia. It aims to characterize the seismic activity and aid in the understanding of the internal structure of Mars. We focus on the Cerberus Fossae region, a giant fracture network ∼1,200 km long situated east of the InSight landing site where M ∼3 marsquakes were detected during the past 2 years. It is formed of five main fossae located on the southeast of the Elysium Mons volcanic rise. We perform a detailed mapping of the entire system based on high‐resolution satellite images and Digital Elevation Models. The refined cartography reveals a range of morphologies associated with dike activity at depth. Width and throw measurements of the fossae are linearly correlated, suggesting a possible tectonic control on the shapes of the fossae. Widths and throws decrease toward the east, indicating the long‐term direction of propagation of the dike‐induced graben system. They also give insights into the geometry at depth and how the possible faults and fractures are rooted in the crust. The exceptional preservation of the fossae allows us to detect up to four scales of segmentation, each formed by a similar number of 3–4 segments/subsegments. This generic distribution is comparable to continental faults and fractures on Earth. We anticipate higher stress and potential marsquakes within intersegment zones and at graben tips.
RapidET: a MEMS-based platform for label-free and rapid demarcation of tumors from normal breast biopsy tissues
Authors: G. K. Anil Vishnu , Gogoi Gayatri , Behera Bhagaban , Rila Saeed , Rangarajan Annapoorni , Pandya Hardik J. 
Published: January 2022

AbstractThe rapid and label-free diagnosis of malignancies in ex vivo breast biopsy tissues has significant utility in pathology laboratories and operating rooms. We report a MEMS-based platform integrated with microchips that performs phenotyping of breast biopsy tissues using electrothermal sensing. The microchip, fabricated on a silicon substrate, incorporates a platinum microheater, interdigitated electrodes (IDEs), and resistance temperature detectors (RTDs) as on-chip sensing elements. The microchips are integrated onto the platform using a slide-fit contact enabling quick replacement for biological measurements. The bulk resistivity (ρB), surface resistivity (ρS), and thermal conductivity (k) of deparaffinized and formalin-fixed paired tumor and adjacent normal breast biopsy samples fromN = 8 patients were measured. For formalin-fixed samples, the meanρBfor tumors showed a statistically significant fold change of 4.42 (P = 0.014) when the tissue was heated from 25 °C to 37 °C compared to the adjacent normal tissue, which showed a fold change of 3.47. The meanρSmeasurements also showed a similar trend. The meankof the formalin-fixed tumor tissues was 0.309 ± 0.02 W m−1 K−1compared to a significantly higherkof 0.563 ± 0.028 W m−1 K−1for the adjacent normal tissues. A similar trend was observed inρB,ρS,andkfor the deparaffinized tissue samples. An analysis of a combination ofρB,ρS, andkusing Fisher’s combined probability test and linear regression suggests the advantage of using all three parameters simultaneously for distinguishing tumors from adjacent normal tissues with higher statistical significance.
Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations
Authors: Zhu Huiyuan , Bi Dexi , Zhang Youhua , Kong Cheng , Du Jiahao , Wu Xiawei , Wei Qing , Qin Huanlong 
Published: January 2022

AbstractThe ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet regimen that mimics the metabolism of the fasting state to induce the production of ketone bodies. The KD has long been established as a remarkably successful dietary approach for the treatment of intractable epilepsy and has increasingly garnered research attention rapidly in the past decade, subject to emerging evidence of the promising therapeutic potential of the KD for various diseases, besides epilepsy, from obesity to malignancies. In this review, we summarize the experimental and/or clinical evidence of the efficacy and safety of the KD in different diseases, and discuss the possible mechanisms of action based on recent advances in understanding the influence of the KD at the cellular and molecular levels. We emphasize that the KD may function through multiple mechanisms, which remain to be further elucidated. The challenges and future directions for the clinical implementation of the KD in the treatment of a spectrum of diseases have been discussed. We suggest that, with encouraging evidence of therapeutic effects and increasing insights into the mechanisms of action, randomized controlled trials should be conducted to elucidate a foundation for the clinical use of the KD.
Organochlorine contamination enriches virus-encoded metabolism and pesticide degradation associated auxiliary genes in soil microbiomes
Authors: Zheng Xiaoxuan , Jahn Martin T , Sun Mingming , Friman Ville-Petri , Balcazar Jose Luis , Wang Jinfeng , Shi Yu , Gong Xin , Hu Feng , Zhu Yong-Guan 
Published: January 2022

Abstract
Viruses significantly influence local and global biogeochemical cycles and help bacteria to survive in different environments by encoding various auxiliary metabolic genes (AMGs) associated with energy acquisition, stress tolerance and degradation of xenobiotics. Here we studied whether bacterial (dsDNA) virus encoded AMGs are enriched in organochlorine pesticide (OCP) contaminated soil in China and if viral AMGs include genes linked to OCP biodegradation. Using metagenomics, we found that OCP-contaminated soils displayed a lower bacterial, but higher diversity of viruses that harbored a higher relative abundance of AMGs linked to pesticide degradation and metabolism. Furthermore, the diversity and relative abundance of AMGs significantly increased along with the severity of pesticide contamination, and several biodegradation genes were identified bioinformatically in viral metagenomes. Functional assays were conducted to experimentally demonstrate that virus-encoded L-2-haloacid dehalogenase gene (L-DEX) is responsible for the degradation of L-2-haloacid pesticide precursors, improving bacterial growth at sub-inhibitory pesticide concentrations. Taken together, these results demonstrate that virus-encoded AMGs are linked to bacterial metabolism and biodegradation, being more abundant and diverse in soils contaminated with pesticides. Moreover, our findings highlight the importance of virus-encoded accessory genes for bacterial ecology in stressful environments, providing a novel avenue for using viruses in the bioremediation of contaminated soils.
Evidence and consequences of academic drift in the field of dental research: A bibliometric analysis 2000–2015
Authors: van der Wouden Puck , van der Heijden Geert , Shemesh Hagay , van den Besselaar Peter 
Published: January 2022

AbstractThe mission of academic excellence has resulted in a science system that incentivises publications within high impact, often basic science journals, and less in application-oriented journals. For the dental research field this so-called academic drift can result in a research portfolio that moves away from research that serves dental healthcare. Therefore, we examined if and how academic drift has changed the dental research field. Web of Science data were used to develop a network map for dental research containing journal clusters that show similar citation behavior. From the year 2000 up to 2015, we explored the intensity of knowledge exchange between the different clusters through citation relations. Next, we analyzed changes in research focus of dental research institutes in seven countries, in dental research, clinical medicine research, basic science, public health research and other fields. Within the citation network, 85.5% of all references in dental journals concern references to other dental journals. The knowledge contribution of non-dental research fields to dental research was limited during the studied period. At the same time, the share of output of dental research institutes in dental research has declined. The research activity of the dental research institutes increased mainly in basic science while the knowledge input from basic science into dental research did not increase. Our findings suggest that the dental research portfolio is influenced by academic drift. This academic drift has increased the disbalance towards basic science, and presents a challenge for the scientific progress in dental healthcare services.
The histone methyltransferase DOT1L is a new epigenetic regulator of pulmonary fibrosis
Authors: Yang Di , Xu Peng , Su Haibi , Zhong Wen , Xu Jie , Su Zhenghua , Liu Xinhua 
Published: January 2022

AbstractIdiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with increasing occurrence, high death rates, and unfavorable treatment regimens. The pathogenesis underlying IPF is complex and the epigenetic contributions to IPF are largely unknown. Recent studies have shown that DOT1L (Disruptor of telomeric silencing-1 like), a histone H3K79 methyltransferase, contributes to fibrosis response, but its role in IPF remains unclear. DOT1L, H3K79me3, and the profibrotic proteins levels were upregulated in the pulmonary fibrosis models both in vivo and in vitro. Lentivirus-mediated DOT1L knockdown or DOT1L-specific inhibitor EPZ5676 alleviated the pathogenesis of bleomycin-induced mouse pulmonary fibrosis. Furthermore, heterozygous DOT1L-deficient mice (Dot1l+/−) showed less sensitive to pulmonary fibrosis, as shown by decreased lung fibrosis phenotypes in vivo. Mechanically, DOT1L regulated TGF-β1-induced fibroblasts fibrosis by increasing enrichments of H3K79me3 on the promoter of Jag1 gene (encoding the Notch ligand Jagged1), enhancing the expression of Jagged1, which in turn stimulated exuberant Notch signaling and actuated the fibrosis response. In conclusion, our study confirmed DOT1L to be an epigenetic modifier in the pathogenesis of lung fibrosis, revealed a counterbalancing mechanism governing Jag1 transcription by modulating H3K79 trimethylation at the Jag1 promoter, activating the Notch signaling, and affecting the expression of profibrotic proteins to accelerate the lung fibrosis.
Blocking autophagy overcomes resistance to dual histone deacetylase and proteasome inhibition in gynecologic cancer
Authors: Bi Jianling , Zhang Yuping , Malmrose Paige K. , Losh Haley A. , Newtson Andreea M. , Devor Eric J. , Thiel Kristina W. , Leslie Kimberly K. 
Published: January 2022

AbstractHistone deacetylase (HDAC) inhibitors and proteasome inhibitors have been approved by the FDA for the treatment of multiple myeloma and lymphoma, respectively, but have not achieved similar activity as single agents in solid tumors. Preclinical studies have demonstrated the activity of the combination of an HDAC inhibitor and a proteasome inhibitor in a variety of tumor models. However, the mechanisms underlying sensitivity and resistance to this combination are not well-understood. This study explores the role of autophagy in adaptive resistance to dual HDAC and proteasome inhibition. Studies focus on ovarian and endometrial gynecologic cancers, two diseases with high mortality and a need for novel treatment approaches. We found that nanomolar concentrations of the proteasome inhibitor ixazomib and HDAC inhibitor romidepsin synergistically induce cell death in the majority of gynecologic cancer cells and patient-derived organoid (PDO) models created using endometrial and ovarian patient tumor tissue. However, some models were not sensitive to this combination, and mechanistic studies implicated autophagy as the main mediator of cell survival in the context of dual HDAC and proteasome inhibition. Whereas the combination of ixazomib and romidepsin reduces autophagy in sensitive gynecologic cancer models, autophagy is induced following drug treatment of resistant cells. Pharmacologic or genetic inhibition of autophagy in resistant cells reverses drug resistance as evidenced by an enhanced anti-tumor response both in vitro and in vivo. Taken together, our findings demonstrate a role for autophagic-mediated cell survival in proteasome inhibitor and HDAC inhibitor-resistant gynecologic cancer cells. These data reveal a new approach to overcome drug resistance by inhibiting the autophagy pathway.
MCAD deficiency caused by compound heterozygous pathogenic variants in ACADM
Authors: Nohara Fumikatsu , Tajima Go , Sasai Hideo , Makita Yoshio 
Published: January 2022

AbstractMedium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency is an autosomal recessive disease caused by biallelic pathogenic ACADM variants. We report a case of an asymptomatic Japanese girl with MCAD deficiency caused by compound heterozygous pathogenic variants (NM_000016.5:c.1040G > T (p.Gly347Val) and c.449_452delCTGA (p.Thr150ArgfsTer4)). Because the MCAD residual activity in lymphocytes of the patient was below the limit of quantification, both variants are likely to cause complete loss of MCAD enzymatic activity.
Synthetic DNA applications in information technology
Authors: Meiser Linda C. , Nguyen Bichlien H. , Chen Yuan-Jyue , Nivala Jeff , Strauss Karin , Ceze Luis , Grass Robert N. 
Published: January 2022

AbstractSynthetic DNA is a growing alternative to electronic-based technologies in fields such as data storage, product tagging, or signal processing. Its value lies in its characteristic attributes, namely Watson-Crick base pairing, array synthesis, sequencing, toehold displacement and polymerase chain reaction (PCR) capabilities. In this review, we provide an overview of the most prevalent applications of synthetic DNA that could shape the future of information technology. We emphasize the reasons why the biomolecule can be a valuable alternative for conventional electronic-based media, and give insights on where the DNA-analog technology stands with respect to its electronic counterparts.
Giant room temperature compression and bending in ferroelectric oxide pillars
Authors: Liu Ying , Cui Xiangyuan , Niu Ranming , Zhang Shujun , Liao Xiaozhou , Moss Scott D. , Finkel Peter , Garbrecht Magnus , Ringer Simon P. , Cairney Julie M. 
Published: January 2022

AbstractPlastic deformation in ceramic materials is normally only observed in nanometre-sized samples. However, we have observed high levels of plasticity (>50% plastic strain) and excellent elasticity (6% elastic strain) in perovskite oxide Pb(In1/2Nb1/2)O3-Pb(Mg1/3Nb2/3)O3-PbTiO3, under compression along <100>pc pillars up to 2.1 μm in diameter. The extent of this deformation is much higher than has previously been reported for ceramic materials, and the sample size at which plasticity is observed is almost an order of magnitude larger. Bending tests also revealed over 8% flexural strain. Plastic deformation occurred by slip along {110} <1$$\bar{1}$$

1

¯

0 > . Calculations indicate that the resulting strain gradients will give rise to giant flexoelectric polarization. First principles models predict that a high concentration of oxygen vacancies weaken the covalent/ionic bonds, giving rise to the unexpected plasticity. Mechanical testing on oxygen vacancies-rich Mn-doped Pb(In1/2Nb1/2)O3-Pb(Mg1/3Nb2/3)O3-PbTiO3 confirmed this prediction. These findings will facilitate the design of plastic ceramic materials and the development of flexoelectric-based nano-electromechanical systems.
Epigenetic aging of the demographically non-aging naked mole-rat
Authors: Kerepesi Csaba , Meer Margarita V. , Ablaeva Julia , Amoroso Vince G. , Lee Sang-Goo , Zhang Bohan , Gerashchenko Maxim V. , Trapp Alexandre , Yim Sun Hee , Lu Ake T. , Levine Morgan E. , Seluanov Andrei , Horvath Steve , Park Thomas J. , Gorbunova Vera , Gladyshev Vadim N. 
Published: January 2022

AbstractThe naked mole-rat (NMR) is an exceptionally long-lived rodent that shows no increase of mortality with age, defining it as a demographically non-aging mammal. Here, we perform bisulfite sequencing of the blood of > 100 NMRs, assessing > 3 million common CpG sites. Unsupervised clustering based on sites whose methylation correlates with age reveals an age-related methylome remodeling, and we also observe a methylome information loss, suggesting that NMRs age. We develop an epigenetic aging clock that accurately predicts the NMR age. We show that these animals age much slower than mice and much faster than humans, consistent with their known maximum lifespans. Interestingly, patterns of age-related changes of clock sites in Tert and Prpf19 differ between NMRs and mice, but there are also sites conserved between the two species. Together, the data indicate that NMRs, like other mammals, epigenetically age even in the absence of demographic aging of this species.
Low N2O and variable CH4 fluxes from tropical forest soils of the Congo Basin
Authors: Barthel Matti , Bauters Marijn , Baumgartner Simon , Drake Travis W. , Bey Nivens Mokwele , Bush Glenn , Boeckx Pascal , Botefa Clement Ikene , Dériaz Nathanaël , Ekamba Gode Lompoko , Gallarotti Nora , Mbayu Faustin M. , Mugula John Kalume , Makelele Isaac Ahanamungu , Mbongo Christian Ekamba , Mohn Joachim , Mandea Joseph Zambo , Mpambi Davin Mata , Ntaboba Landry Cizungu , Rukeza Montfort Bagalwa , Spencer Robert G. M. , Summerauer Laura , Vanlauwe Bernard , Van Oost Kristof , Wolf Benjamin , Six Johan 
Published: January 2022

AbstractGlobally, tropical forests are assumed to be an important source of atmospheric nitrous oxide (N2O) and sink for methane (CH4). Yet, although the Congo Basin comprises the second largest tropical forest and is considered the most pristine large basin left on Earth, in situ N2O and CH4 flux measurements are scarce. Here, we provide multi-year data derived from on-ground soil flux (n = 1558) and riverine dissolved gas concentration (n = 332) measurements spanning montane, swamp, and lowland forests. Each forest type core monitoring site was sampled at least for one hydrological year between 2016 - 2020 at a frequency of 7-14 days. We estimate a terrestrial CH4 uptake (in kg CH4-C ha−1 yr−1) for montane (−4.28) and lowland forests (−3.52) and a massive CH4 release from swamp forests (non-inundated 2.68; inundated 341). All investigated forest types were a N2O source (except for inundated swamp forest) with 0.93, 1.56, 3.5, and −0.19 kg N2O-N ha−1 yr−1 for montane, lowland, non-inundated swamp, and inundated swamp forests, respectively.