bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISA PENGENDALIAN PERSEDIAN BAHAN BAKU KEMASAN CUP 240 ML DENGAN MENGGUNAKAN METODE EOQ (ECONOMIC ORDER QUANTITY) DI PT. DEF BATAM
Authors: Sumarya Edi 
Published: July 2022

Penelitian ini dilakukan terhadap persediaan bahan baku kemasan cup 240 ml untuk mengetahui jumlah pembelian yang optimum pada bahan baku kemasan cup 240 ml dengan menggunakan metode EOQ (Economic Order Quantity), untuk mengetahui persediaan pengaman (Safety Stock) pada bulan Juli tahun 2018 sampai dengan Juni 2019 di PT DEF Batam. Untuk mengetahui: Kapan seharusnya melakukan pemesanan kembali (Re Order Point), untuk mengetahui perbandingan yang lebih optimum antara menggunakan Total Inventory Cost (“TIC) yang ditetapan perusahaan dengan total biaya persediaan atau Total Inventory Cost (TIC) menggunakan metode EOQ (Economic Order Quantity). Metode yang digunakan adalah metode kualitatif. Hasil penelitian ini menunjukan bahwa: jumlah pemesanan kemasan cup 240 ml yang optimum pada bulan Juli tahun 2018 – Juni 2019 adalah 15941350 pcs, setiap kali pemesanan, dan frequensi pemesanan dilakukan dua kali dalam satu tahun. Jumlah Safety Stock dalam bulan Juli tahun 2018 – Juni 2019 adalah sebesar 63050 pcs. Re Order Point yang harus dilakukan kembali oleh perusahaan pada tahun 2018-2019 adalah ketika persediaan bahan kemasan cup sebesar 443080 pcs. Perbandingan Total inventory Cost (TIC) Perusahaan sebesar Rp. 437.661.800 dengan Total Inventory Cost (TIC) EOQ sebesar Rp 162601730
The specialty of allergy and clinical immunology in Brazil
Authors: de Mello Luane Marques , Serpa Faradiba Sarquis , Chiabai Joseane , Fernandes Fátima Rodrigues , Chong-Neto Herberto José , Sarinho Emanuel Sávio Cavalcanti , Rubini Norma de Paula Motta , Solé Dirceu 
Published: July 2022

ObjectiveTo assess the profile of allergist/immunologist (A/I) physicians in Brazil, the workplace, the access to diagnostic and therapeutic procedures, and the impact of the COVID-19 pandemic on professional practice.MethodsThis cross-sectional study was conducted as an online survey. All adhering members of the Brazilian Association of Allergy and Immunology (ASBAI) received a Google Forms tool by email. The questionnaire addressed sociodemographic and professional aspects of the Brazilian allergists/immunologists (A/I) daily routine. The information was analyzed by SPSS version 20.0.ResultsFour hundred and sixty members answered the questionnaire. Women were predominant among the responders (336; 73%), and the median age was 47 years (range, 27–82 years). Most participants worked in the private sector (437, 95%), whereas 256 (47%) worked in the public sector. Among the public sector employees, 210 (82%) reported having access to some diagnostic test for allergic diseases and inborn errors of immunity. Only 91 (35%) A/I physicians in the public system had access to allergen-specific immunotherapy, compared to 416 (95, 9%) of those in the private sector. Regarding biological drugs, 135 (52.7%) and 314 (71.9%) of the A/I physicians working in the public and private sector, respectively, reported access. Two hundred and eighty-three (61.6%) had at least a 50% reduction in the number of consultations, and 245 (56%) provided telemedicine care during the COVID-19 pandemic.ConclusionBrazilian A/I have incorporated the most recent advances in managing immunoallergic diseases into their clinical practice, but they still have little access to various diagnostic methods. Strategies to enable the presence of A/I in public health services should be discussed and implemented. The coronavirus pandemic has accelerated the incorporation of telemedicine as a viable and promising method of medical care and can expand access to the specialty.
Identification of the prognostic signature based on genomic instability-related alternative splicing in colorectal cancer and its regulatory network
Authors: Ding Qiuying , Hou Zhengping , Zhao Zhibo , Chen Yao , Zhao Lei , Xiang Yue 
Published: July 2022

Background: Colorectal cancer (CRC) is a heterogeneous disease with many somatic mutations defining its genomic instability. Alternative Splicing (AS) events, are essential for maintaining genomic instability. However, the role of genomic instability-related AS events in CRC has not been investigated.Methods: From The Cancer Genome Atlas (TCGA) program, we obtained the splicing profiles, the single nucleotide polymorphism, transcriptomics, and clinical information of CRC. Combining somatic mutation and AS events data, a genomic instability-related AS signature was constructed for CRC. Mutations analyses, clinical stratification analyses, and multivariate Cox regression analyses evaluated this signature in training set. Subsequently, we validated the sensitivity and specificity of this prognostic signature using a test set and the entire TCGA dataset. We constructed a nomogram for the prognosis prediction of CRC patients. Differentially infiltrating immune cells were screened by using CIBERSORT. Inmmunophenoscore (IPS) analysis was used to evaluate the response of immunotherapy. The AS events-related splicing factors (SF) were analyzed by Pearson’s correlation. The effects of SF regulating the prognostic AS events in proliferation and migration were validated in Caco2 cells.Results: A prognostic signature consisting of seven AS events (PDHA1-88633-ES, KIAA1522-1632-AP, TATDN1-85088-ES, PRMT1-51042-ES, VEZT-23786-ES, AIG1-77972-AT, and PHF11-25891-AP) was constructed. Patients in the high-risk score group showed a higher somatic mutation. The genomic instability risk score was an independent variable associated with overall survival (OS), with a hazard ratio of a risk score of 1.537. The area under the curve of receiver operator characteristic curve of the genomic instability risk score in predicting the OS of CRC patients was 0.733. Furthermore, a nomogram was established and could be used clinically to stratify patients to predict prognosis. Patients defined as high-risk by this signature showed a lower proportion of eosinophils than the low-risk group. Patients with low risk were more sensitive to anti-CTLA4 immunotherapy. Additionally, HSPA1A and FAM50B were two SF regulating the OS-related AS. Downregulation of HSPA1A and FAM50B inhibited the proliferation and migration of Caco2 cells.Conclusion: We constructed an ideal prognostic signature reflecting the genomic instability and OS of CRC patients. HSPA1A and FAM50B were verified as two important SF regulating the OS-related AS.
Antioxidant, Cytotoxic, and Antimicrobial Potential of Silver Nanoparticles Synthesized using Tradescantia pallida Extract
Authors: Shahzadi Irum , Aziz Shah Syed Munawar , Shah Mohammad Maroof , Ismail Tariq , Fatima Nighat , Siddique Maria , Waheed Ummara , Baig Ayesha , Ayaz Aisha 
Published: July 2022

Silver nanoparticles have received much attention, due to their wide range of biological applications as an alternative therapy for disease conditions utilizing the nanobiotechnology domain for synthesis. The current study was performed to examine the antioxidant, anticancer, antibacterial, and antifungal potential of biosynthesized silver nanoparticles (TpAgNPs) using plant extract. The TpAgNPs were produced by reacting the Tradescantia pallida extract and AgNO3 solution in nine various concentration ratios subjected to bioactivities profiling. According to the current findings, plant extract comprising phenolics, flavonoids, and especially anthocyanins played a critical role in the production of TpAgNPs. UV–visible spectroscopy also validated the TpAgNP formation in the peak range of 401–441 nm. Further, the silver ion stabilization by phytochemicals, face-centered cubic structure, crystal size, and spherical morphology of TpAgNPs were analyzed by FTIR, XRD, and SEM. Among all TpAgNPs, the biosynthesized TpAgNP6 with a medium concentration ratio (5:10) and the plant extract had effective antioxidant potentials of 77.2 ± 1.0% and 45.1 ± 0.5% free radical scavenging activity, respectively. The cytotoxic activity of TpAgNP6 in comparison to plant extract for the rhabdomyosarcoma cell line was significantly the lowest with IC50 values of 81.5 ± 1.9 and 90.59 ± 1.6 μg/ml and cell viability % of 24.3 ± 1.62 and 27.4 ± 1.05, respectively. The antibacterial and antifungal results of TpAgNPs revealed significant improvement in comparison to plant extract, i.e., minimum inhibition concentration (MIC) 64 μg/ml against Gram-negative Pseudomonas aeruginosa while, in the case of antifungal assay, TpAgNP6 was active against Candida parapsilosis. These TpAgNPs play a crucial role in determining the therapeutic potential of T. pallida due to their biological efficacy.
Pattern and Predictive Factors of Metastasis in Lymph Nodes Posterior to the Right Recurrent Laryngeal Nerve in Papillary Thyroid Carcinoma
Authors: Zhou Mengqian , Duan Yuansheng , Ye Beibei , Wang Yuxuan , Li Hong , Wu Yue , Chen Peng , Zhu Jiajia , Jing Chao , Wu Yansheng , Wang Xudong 
Published: July 2022

ObjectiveThe right cervical central lymph nodes include lymph nodes anterior to the right recurrent laryngeal nerve (LN-arRLN) and lymph nodes posterior to the right recurrent laryngeal nerve (LN-prRLN), and are separated by the right recurrent laryngeal nerve (RLN). LN-prRLN is a common site of nodal recurrence after the resection of papillary thyroid carcinoma (PTC). However, the complexity in anatomical structure brings difficulties in determining the surgical scope, so it is necessary to assess the pattern and predictive factors of right cervical central lymph nodes, especially LN-prRLN metastasis in papillary thyroid carcinoma.MethodsA total of 562 diagnosed PTC patients who underwent right or total thyroidectomy were enrolled in this retrospective study. The clinicopathological features were collected, univariate and multivariate analyses were performed to determine predictive factors of the right central lymph node metastasis.ResultsIn this study, the metastatic rates of the right CLN, the LN-arRLN and the LN-prRLN were 59.6% (335/562), 51.8% (291/562) and 30.4% (171/562), respectively. And 22.6% (127/562) of patients had both LN-arRLN and LN-prRLN metastasis. Among patients without LN-arRLN metastasis, the rate of LN-prRLN metastasis was 16.2% (44/271), accounting for 25.7% of the LN-prRLN metastasis group. Factors associated with an increased risk of LN-arRLN metastasis include male, age below 55 years, tumor size &gt; 1cm, extrathyroidal extension (ETE), clinical lymph nodes metastasis(cN1), lateral lymph node metastasis, and left CLN metastasis. In addition, ETE, lateral lymph node metastasis, and LN-arRLN metastasis were independent factors of LN-prRLN metastasis. The predictive factors of LN-prRLN in cN0 PTC were further explored, revealing that tumor size ≥1.5cm, ETE, and LN-arRLN metastasis were independent predictors of LN-prRLN metastasis in cN0 PTC.ConclusionThe LN-prRLN should not be ignored in surgery because of its high rate of metastasis. Our findings indicate that thorough dissection of central lymph nodes, especially LN-prRLN is crucial in clinical work.
The Association Between the Triglyceride-to-High-Density Lipoprotein Cholesterol Ratio and the Risk of Progression to Diabetes From Prediabetes: A 5-year Cohort Study in Chinese Adults
Authors: Sun Yanfei , Wang Zhibin , Huang Zhiqiang , Hu Haofei , Han Yong 
Published: July 2022

ObjectiveEvidence regarding the relationship between the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-c) ratio and the risk of progression from prediabetes to diabetes remains limited. The purpose of our study was to investigate the relationship between the TG/HDL-C ratio and incident diabetes in prediabetic patients.MethodsThis retrospective cohort study covered 32 regions and 11 cities in China and consecutively and non-selectively collected data from 15,017 patients with prediabetes who had received a health check from 2010 to 2016. Data were obtained from the DATADRYAD database (www.datadryad.org). The Cox proportional-hazards regression model with cubic spline functions and smooth curve fitting (cubic spline smoothing) was used to explore the non-linear relationship between the baseline TG/HDL-c ratio and the risk of diabetes in patients with prediabetes. In addition, we performed a series of sensitivity and subgroup analyses.ResultsThe mean age of the included individuals was 50.95 ± 13.48 years, and 9,745 (64.51%) were men. The median (interquartile range) TG/HDL-c ratio was 1.09 (0.69–1.72). During a median follow-up time of 3.05 years, 1,731 (11.46%) patients had a final diagnosis of diabetes. The analysis after adjusting for covariates showed that the TG/HDL-c ratio was positively related to incident diabetes in patients with prediabetes (HR = 1.111, 95% CI 1.061–1.164). Participants with the highest TG/HDL-c ratio (Q4) had higher diabetes incidence rates than those with the lowest TG/HDL-c ratio (Q1) (P &lt; 0.001 for the trend). There was a non-linear relationship between the TG/HDL-c ratio and the risk of diabetes, and the inflection point of the TG/HDL-c ratio was 1.415. The effect sizes (HR) on the left and right sides of the inflection point were 1.336 (95% CI: 1.134–1.573) and 1.055 (95% CI: 0.988–1.126), respectively. The sensitivity analysis demonstrated the robustness of these results.ConclusionThis study demonstrates a positive, non-linear relationship between the TG/HDL-c ratio and the risk of diabetes in Chinese patients with prediabetes. Aggressive intervention from a treatment perspective is required to lower the TG/HDL-c ratio below the inflection point (1.415) by lowering TG or increasing HDL-c levels.
Metal-Organic Framework Supporting Fe3O4 Prepared by Microwave in Couple With NTP to Eliminate VOCs From Biofuel
Authors: Gao Yan , Cao Qing , Guan Ning , Zhang Zhanchao , Fan Guolan , Dou Huawei , Li Shijie , Wang Qiang , Chen Baoming 
Published: July 2022

In the production process of briquette biofuel, terpenes such as pinene and camphene, as well as non-terpenoid VOCs such as formic acid, acetaldehyde, and benzene, are generated during conditioning, drying and other procedures. Different catalysts of Fe3O4 supported by CoFe-ZIFs were prepared by thermal dissolution method and microwave dissolution method with changing the doping amount of iron. The structures of these catalysts were characterized by X-ray Diffraction (XRD), Fourier transform infrared spectrometer Fourier-Transformed InfraRed, thermogravimetric analysis (TG), and scanning electron microscope and the catalytic performance for α-pinene was tested on a fixed bed. The results show that, compared with the thermal dissolution method, the microwave dissolution method was easier to induce iron to form Fe3O4 grains with higher activity. At the same time, the grains did not affect the formation of CoFe-ZIFs structure. Fe3O4 supported on CoFe-ZIFs enhanced the catalytic activity and energy efficiency of the catalysts for α-pinene. Among the test samples, CoFe14-ZIF-W prepared by microwave method with Fe doping 14% mol exhibited the stable structural characteristics and the highest catalytic efficiency of 94.3% and energy efficiency of 8.11 g·kWh−1, which provided a further possibility of practical application for the removal of VOCs from biomass.
When the Eel Meets Dams: Larger Dams’ Long-Term Impacts on Anguilla anguilla (L., 1758)
Authors: Podda Cinzia , Palmas Francesco , Pusceddu Antonio , Sabatini Andrea 
Published: July 2022

Diadromous fish, like the European eel Anguilla anguilla (L., 1758), are highly threatened by dams that disrupt river connectivity, consequently impeding fish movements to reach feeding and spawning habitats. In this study, variation in eel occurrence between a historical period (1940–1970) and recent data (2016–2020) was assessed throughout the Sardinian rivers’ network (more than 450 sites). Using Boosted Regression Trees (BRT) we investigated relationships between eel’s occurrence and a set of spatial and temporal environmental variables including a set of dams’ construction features for each period. An overall decrease by 65% of eel’s occurrence was noticed during the ca. 80-years period under scrutiny. Considering a subset (105 and 88 sites for the historical and the recent period, respectively) characterized by the presence of larger dams (height &gt;15 m), eel’s occurrence dropped by 85%. Conversely, eel’s occurrence dropped only by ca. 44% in dam-free sites. During the historical period, eel’s occurrence was mostly affected by time since the initial habitat fragmentation, flow, distance to dams, connectivity, and dams’ height. In the most recent period, eel’s occurrence is mostly affected by dams’ building year, dam-to-sea distance, and, again, dams’ height. Results pinpoint that dams’ construction features and the time from their construction have significant negative effects on eel’s occurrence. Addition of future effective eel restoration practices, apart any other adverse environmental stressor, must consider dams’ removal, wherever socially sustainable or alternatively, the modification of construction features of dams (like excessive height) and the addition of fish ladders.
Multi-organ Immune-Related Adverse Event Is a Risk Factor of Immune Checkpoint Inhibitor-Associated Myocarditis in Cancer Patients: A Multi-center Study
Authors: Xie Xiaohong , Wang Liqiang , Li Yingqing , Xu Yan , Wu Jianhui , Lin Xinqing , Lin Wen , Mai Qicong , Chen Zhanhong , Zhang Jiexia , Xie Zhanhong , Qin Yinyin , Liu Ming , Lu Mingjun , Luo Bihui , Zhou Chengzhi 
Published: July 2022

Background and ObjectiveImmune checkpoint inhibitor (ICI)-associated myocarditis is a fatal immune-related adverse events (irAEs), which is prone to affecting multiple organ systems. Multi-organ irAEs have not been fully studied in ICI-associated myocarditis. Therefore, we aimed to explore the impact of multi-organ irAEs on ICI myocarditis in terms of clinical features, treatment, and prognosis.MethodsThis was a retrospective study. The clinical data of ICI myocarditis patients were collected from 6 hospitals in China. The risk factors and characteristics of pure myocarditis and multi-organ irAEs were analyzed. The overall survival (OS) after myocarditis was analyzed and univariate and multivariate regression analysis were performed.ResultsA total of 46 patients were analyzed in this study. Multi-organ irAEs were common (30/46, 65.2%) and prone to severe heart failure. The severe myocarditis was observed in 32 patients (69.6%). When myocarditis occurred, neutrophil to lymphocyte ratio, C-reactive protein, lactate dehydrogenase, interleukin (IL)-6, IL-10, creatine kinase, MB isoenzyme of creatine kinase, and brain natriuretic peptide increased from baseline, but absolute lymphocyte count decreased. Thymoma (B2/B3) was a risk factor for multi-organ irAEs. Heart failure and myocarditis were more severe in patients with multi-organ irAEs and require early corticosteroid therapy (&lt;24 hours). Univariate analysis showed that age ≥ 60 years, myocarditis (grade 3-4), heart failure (grade 3-4), multi-organ irAEs, and severe myocarditis were associated with OS after myocarditis. After adjusting for other factors, heart failure (grade 3-4) was an independent risk factor for immune-related myocarditis (HR: 6.655, 95% CI: 1.539-28.770, p=0.011).ConclusionPatients with ICI-associated myocarditis had multi-organ irAEs with a high incidence of severe myocarditis, mortality, and poor prognosis. Thymoma was prone to those patients with multiple organs involvement. Patients could benefit from early corticosteroid intervention. Heart failure (grade 3-4) was an independent risk factor for OS after myocarditis.
SARS-CoV-2-Specific Adaptive Immunity in COVID-19 Survivors With Asthma
Authors: Chen Li , Yue Junqing , Zhang Shengding , Bai Wenxue , Qin Lu , Zhang Cong , Wu Bihao , Li Moxuan , Xu Shuyun , Jiang Qing , Yang Lin , Xu Qingxiu , Zhu Rongfei , Xie Min , Gong Rui 
Published: July 2022

BackgroundAsthma patients potentially have impaired adaptive immunity to virus infection. The levels of SARS-CoV-2-specific adaptive immunity between COVID-19 survivors with and without asthma are presently unclear.MethodsCOVID-19 survivors (patients with asthma n=11, with allergies n=8, and COVID-19 only n=17) and non-COVID-19 individuals (asthmatic patients n=10 and healthy controls n=9) were included. The COVID-19 patients were followed up at about 8 months and 16 months after discharge. The clinical characteristics, lymphocyte subsets, memory T cells, and humoral immunity including SARS-CoV-2 specific antibodies, SARS-CoV-2 pseudotyped virus neutralization assay, and memory B cells were analyzed in these subjects.ResultsThe strength of virus-specific T cell response in COVID-19 survivors was positively correlated with the percentage of blood eosinophils and Treg cells (r=0.4007, p=0.0188; and r=0.4435, p=0.0086 respectively) at 8-month follow-up. There were no statistical differences in the levels of SARS-CoV-2-specific T cell response between the COVID-19 survivors with, and without, asthma. Compared to those without asthma, the COVID-19 with asthma survivors had higher levels of SARS-CoV-2-specific neutralizing antibodies (NAbs) at the 8-month follow-up (p&lt;0.05). Moreover, the level of NAbs in COVID-19 survivors was positively correlated with the percentage of Treg and cTfh2 cells (r=0.5037, p=0.002; and r=0.4846, p=0.0141), and negatively correlated with the percentage of Th1 and Th17 cells (r=-0.5701, p=0.0003; and r=-0.3656, p=0.0308), the ratio of Th1/Th2, Th17/Treg, and cTfh1/cTfh2 cell (r=-0.5356, r=-0.5947, r=-0.4485; all p&lt;0.05). The decay rate of NAbs in the COVID-19 survivors with asthma was not significantly different from that of those without asthma at 16-month follow-up.ConclusionThe level of SARS-CoV-2-specific NAbs in COVID-19 survivors with asthma was higher than that of those without asthma at 8-month follow-up. The SARS-CoV-2-specific T cell immunity was associated with blood eosinophils and Treg percentages. The SARS-CoV-2-specific humoral immunity was closely associated with cTfh2/cTfh1 imbalance and Treg/Th17 ratio. According to the findings, asthmatic patients in COVID-19 convalescent period may benefit from an enhanced specific humoral immunity, which associates with skewed Th2/Th1 and Treg/Th17 immune.
Bibliometrics analysis on the research status and trends of adult-onset Still’s disease: 1921-2021
Authors: Qin Aining , Sun Jing , Gao Chao , Li Chunying 
Published: July 2022

ObjectivesThe aim of this research is to discuss the research status, hotspots, frontiers and development trends in the field of adult-onset Still’s disease (AOSD) based on bibliometrics and visual analysis by CiteSpace software.MethodsThe relevant research articles on AOSD from 1921 to 2021 were retrieved from the Scopus database. CiteSpace software was used to form a visual knowledge map and conduct analysis for the countries/regions, journals, authors, keywords, clusters, research hotspots and frontiers of the included articles.ResultsThere were 2,373 articles included, and the number of articles published during 1921-2021 is increasing. The country with the highest number of articles published was Japan (355, 14.96%), followed by the United States (329, 13.86%) and France (215, 9.06%). The author with the highest number of publications is Ansell, Barbara M. (30, 1.26%), and the author with the highest co-citation frequency is Yamaguchi, Masaya (703). Clinical Rheumatology is the journal with the highest publication frequency. The top five cluster groups were “joint”, “differential diagnosis”, “prednisolone”, “methotrexate” and “macrophage activation syndrome”. The diagnosis, treatment and pathogenesis of AOSD form the main research fields, and prognosis and complications are the research hotspots and trends.ConclusionsThe global research field in AOSD has expanded in the past 100 years. The complications and new pathogenesis of AOSD are hotspots in this field and need further study in the future.