bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta-Analysis of MiR-122 in Predicting Cardiovascular and Cerebrovascular Diseases
Authors: Kun Jiao , Ping Su , Yubao Feng , Changqing* Li 
Published: January 2022

Abstract
Objective
To evaluate the diagnostic value of MiR-122 in predicting cardiovascular and cerebrovascular diseases systematically.
Methods
Searching China National Knowledge Infrastructure(CNKI), Wanfang Database, VIP Database (VIP), China Biomedical Literature Database (CBM), Clinical Registry, PubMed, Cochrane Library and Embase Library to obtain relevant documents. The time frame is from January 1, 2006 to February 28, 2021. MiR-122 plays a diagnostic role in patients of cardiovascular and cerebrovascular diseases with randomized controlled trials and cross-sectional studies. According to the inclusion and exclusion criteria, the literatures were screened, data extracted and related quality evaluated. Cochrane System Reviewer Manual Version 5.0 was applicable to related quality evaluation and Review Manager 5.3 was used for meta-analysis.
Results
A total of 23 articles were included and 6375 patients altogether. The meta-analysis showed that compared with the control group, MiR-122 was more effective in the patients of myocardial infarction (WMD= -2.33, 95%CI [-2.88,-1.78], P<0.0001), Angina pectoris and cardiovascular disease (WMD= -0.45, 95%CI [-0.61,-0.29], P<0.00001). Cerebrovascular diseases also have higher expression levels of MiR-122(WMD=- 0.34, 95% CI [-0.53, 0.33], P<0.00001). The prognosis of patients with high MiR-122 expression are worse (WMD=-2.20, 95%CI[-2.66,-1.75], P<0.00001). There are differences between the groups, with statistical significance (P<0.05).
Conclusion
MiR-122 has great diagnostic value in predicting cardiovascular and cerebrovascular diseases, and expression is elevated in diseases such as myocardial infarction, angina pectoris and stroke. Thus it has diagnostic value in the prognosis of patients with cardiovascular and cerebrovascular diseases.
The Effectiveness of Group Schema Therapy to Enhance the Cognitive Emotion Regulation Strategies in Women Undergoing Bariatric Surgery During COVID-19
Authors: Sobhani Zahra , Hosseini Seyed Vahid , Honarparvaran Nazanin , Khazraei Hajar , Amini Masood , Hedayati Arvin 
Published: January 2022

Abstract
Background: Emotions, attitudes, and behaviors toward eating play a very important role in obesity and according to a schema-based approach; patients with obesity learn some coping strategies since childhood to cope with the schemas. So, this study aims to evaluate the effectiveness of group schema therapy on the cognitive emotion regulation (CER) strategies in women who underwent bariatric surgery during COVID-19.Methods: Forty women who underwent bariatric surgery were selected and were randomly divided into two groups of control and experimental. The experimental group received ten 90-min sessions of group schema therapy. Both groups completed the CER questionnaire during pre-test, post-test and follow-up stages and data were analyzed using a multivariate analysis of covariance (MANCOVA) in SPSS software (version 20). Results: Our results indicated that the differences between two groups in variables of adaptive CER strategies (P = 0.0001, F = 31.15) and maladaptive CER strategies (P = 0.001, F = 9.42) were significant.Conclusions: The findings demonstrated that group schema therapy training can lead to increases adaptive CER strategies and decrease maladaptive CER strategies in women undergoing bariatric surgery.Trial registration: IRCT, IRCT20180523039802N2. Registered 5 August 2020, http://www.irct.com/IRCT20180523039802N2
Clinical Utility and Impact of the Metagenomic Microbial Plasma Cell-Free DNA Next-Generation Sequencing Assay on Treatment Decision: A Single-Center Retrospective Study
Authors: Shishido Akira , Noe Myint , Saharia Kapil , Luethy Paul 
Published: January 2022

Abstract
Background
Metagenomic next-generation sequencing (mNGS) of microbial cell-free DNA (mcfDNA) allows for non-invasive pathogen detection from plasma. However, there is little data describing the optimal role for this assay in real-world clinical decision making.
Methods
We performed a single-center retrospective cohort study of adult patients for whom a mcfDNA test was sent between May 2019 and February 2021. Clinical impact was arbitrated after review and discussion of each case.
Results
A total of 80 patients were included. The most common reason for sending the assay was unknown microbiologic diagnosis (78%), followed by avoiding invasive procedures (14%). The test had a positive impact in 34 (43%), a negative impact in 2 (3%), and uncertain or no impact in 44 (55%). A positive impact was observed in solid organ transplant recipients (SOTR, 71.4%, p=0.003), sepsis (71.4%, p=0.003), and those receiving antimicrobial agents for less than 7 days prior to mcfDNA testing (i.e., 61.8%, p=0.004).
Conclusion
Clinical utility of mcfDNA testing was highest in SOTR and patients with sepsis. Prolonged antimicrobial use prior to mcfDNA testing limited the utility of the assay. Prospective studies evaluating the utility of mcfDNA assays should be performed to further clarify its role in clinical management.
Potential Role of CTNNA3 And FRMPD4 In Vascular Thrombosis of Colon Adenocarcinoma
Authors: Liu Bin , Xiang Yu , Guo Weihua 
Published: January 2022

Abstract
Background: Vascular tumor thrombus is an important pathological feature of malignant tumors, closely related to lymph node metastasis, and considered to be tumor micrometastasis. Two down-regulated genes, Catenin Alpha 3 (CTNNA3) and FERM And PDZ Domain Containing 4 (FRMPD4) were selected via analyzing the differential expression of vascular tumor thrombus in colon adenocarcinoma and paracancerous tissues. Furthermore, we observed the potential role of them in vascular thrombosis of colon adenocarcinoma.Method: Candidate genes for vascular thrombosis of colon adenocarcinoma were screened by GSE127069, and then pan-cancer verification and immune infiltration analysis were performed. The relationship between gene and vascular thrombosis was analyzed from the level of gene mutation by cBioPortal. Finally, the clinical samples collected were used for expression verification.Results: CTNNA3 and FRMPD4 were low-expressed in vascular tumor thrombus of colon adenocarcinoma, which were positively correlated with microsatellite instability (MSI). They were also closely related to immune microenvironment and immune cell subtype infiltration. According to the analysis of gene mutation, their gene deletion was related to the vascular invasion indicator. Finally, the protein and mRNA expression of CTNNA3 and FRMPD4 were down-regulated in the samples of vascular thrombosis of colon adenocarcinoma, compared with the normal glands which from paracancerous tissues.Conclusion: Our study demonstrates that CTNNA3 and FRMPD4 may be potential biomarkers of vascular thrombosis in colon adenocarcinoma. These results may provide a new strategy to identify the micrometastasis in colon adenocarcinoma.
Physical Function, Psychological Adjustment, and Self-Efficacy Following Sudden Cardiac Arrest and an Initial Implantable Cardioverter Defibrillator (ICD) in a Social Cognitive Theory Intervention: Secondary Analysis of a Randomized Control Trial
Authors: Dougherty Cynthia M. , Liberato Ana Carolina Sauer , Streur Megan M. , Burr Robert L. , Kwan Judy Ka Yee , Zheng Tao , Auld Jon P. , Thompson Elaine A. 
Published: January 2022

Abstract
Background Sudden cardiac arrest (SCA) survivorship results in unique issues in return to physical and psychological function. The purpose of the study was to compare recovery across the first year between SCA survivors and other arrhythmia patients who received an initial implantable cardioverter defibrillator (ICD) for secondary prevention, participating in a social cognitive theory (SCT) intervention.Methods 168 (129 males, 39 females) who received an ICD for secondary prevention (SCA N=65; other arrhythmia N=103) were randomized to one of two study conditions: SCT intervention (N=85) or usual care (N=83). Outcomes were measured at baseline hospital discharge, 1, 3, 6, & 12 months: 1) Physical Function: Patient Concerns Assessment (PCA), SF-36 (PCS); 2) Psychological Adjustment: State Trait Anxiety (STAI), CES-D depression, SF-36 (MCS); 3) Self-Efficacy: Self-Efficacy (SCA-SE), Self-management Behaviors (SMB), Outcome Expectations (OE). Outcomes were compared over 12 months for intervention condition x ICD indication using general estimating equations.Results Participants were Caucasian (89%),age 63.95+12.3 years, mean EF% 33.95+13.9, BMI 28.19+6.2, and Charlson Index 4.27+2.3. Physical symptoms (PCA) were higher over time for SCA survivors compared to the other arrhythmia group (p=0.04), ICD shocks were lower in SCA survivors in the SCT intervention (p=0.01); psychological adjustment (MCS) was significantly lower in SCA survivors in the SCT intervention over 6 months, that improved at 12 months (p=0.05); outcome expectations (OE) were significantly lower for SCA survivors in the SCT intervention (p=0.008).Conclusions SCA survivors had greater number of physical symptoms, lower levels of mental health and outcome expectations over 12 months despite participation in a SCT intervention.Trial registration: Clinicaltrials.gov: NCT04462887
Continuous Non-singular Terminal Sliding Mode Control for Magnetic Levitation Systems
Authors: Wang Junxiao , Lu Qinkun , Yang Jun 
Published: January 2022

Abstract
For attenuating the chattering phenomenon and improving the disturbance suppression for the magnetic levitation control system subject to multiple disturbances and parameter uncertainties, this paper proposes an internal model disturbance observer (IMDO) based continuous non-singular terminal sliding mode control (CNTSMC) scheme. Firstly, a nonlinear dynamic model of the magnetic levitation system is constructed. Then, for ensuring the system position state tracking performance and suppress the chattering phenomenon, a CNTSMC method is designed to make the system state converge to the desired position in finite time. For improving the multiple disturbance rejection, an IMDO based CNTSMC scheme is designed for the system affected by multiple disturbance which includes both high-order and trigonometric function forms. Compared with CNTSMC and CNTSMC+GPIO controller, simulation and experimental results show that the proposed method could improve the position tracking performance and obtains better multiple disturbance rejection. Some control performance indexes for quantitative comparison are also given to supports these results.
Catalytic Ozonation for Phenol Removal over Cobalt-doped α-MnO2 Catalyst: Performance and Mechanism
Authors: Zhang Jie , Dong Ben , Han Ying , Zhan Xiaocui , Ge Sijie , He Shilong 
Published: January 2022

Abstract
In this paper, Cobalt-doped α-MnO2 (i.e., Co-α-MnO2) were synthesized through hydrothermal method. Phenol was employed as targeted pollutants to investigate the catalytic ozonation performance of Co-α-MnO2 in terms of catalytic ability and mechanism. Results showed that that Co doped on α-MnO2 significantly improved the phenol removal increased to 97.47 % after 40 min, which was 16.46 %, 38.92 % higher than that of α-MnO2 catalytic ozonation and single ozonation without catalyst. In order to investigate the effect of Co doping on the physicochemical properties of the catalysts, the synthesized α-MnO2 and Co-α-MnO2 (2% Co/Mn doping ratio) catalysts were characterized by XRD, TEM, BET and XPS techniques, including the phase, morphology, structural properties and dispersity of the surface active species. The larger specific surface area and pore volume, more crystal defect and oxygen vacancy, higher relative content of Mn3+ and adsorbed oxygen (Oads) as well as surface hydroxyl were obtained after Co doping on α-MnO2, which could result in higher catalytic oxidation performance of Co-α-MnO2. The influence of masking agent showed that surface hydroxyl group and active free radicals (•OH and •O2-) were involved in the catalytic ozonation of phenol. This study could help recognize the role of surface hydroxyl groups and active free radicals and demonstrate the contribution of reactive oxygen species (ROS) on phenol removal in Co-α-MnO2 systems.
Radiomic Analysis for Pretreatment Prediction of Recurrence After Radiotherapy in Locally Advanced Cervical Cancer
Authors: Kawahara Daisuke , Nishibuchi Ikuno , Kawamura Masashi , Yoshida Takahito , Koh Iemasa , Tomono Katsuyuki , Sekine Masaki , Takahashi Haruko , Kikuchi Yutaka , Kudo Yoshiki , Nagata Yasushi 
Published: January 2022

Abstract
【Objective】 To predict the recurrence of advanced cervical cancer patients treated with radiotherapy from radiomics features on pre-treatment T1- and T2-weighted MRI images. 【Methods】 A total of 90 patients were split into two sets: 67 patients for model training and 23 patients for model testing. The patient outcome was classified into two groups; patients with a recurrence (group I) and without a recurrence (group II). The predictors were selected using the least absolute shrinkage and selection operator (LASSO) regression. The machine learning for the predictive models was sued neural network classifiers. The accuracy, sensitivity, specificity, and the area under the curve (AUC) from the receiver operating characteristic were evaluated. 【Results】 By the LASSO analysis, we found 25 radiomics features from the T1-weighted MRI image and 4 radiomics features from the T2-weighted MRI image. The accuracy of the prediction model was highest with the combination of T1- and T2-weighted MRI images. The model performances with T1-weighted MRI image and T2-weighted MRI image were 86.4% and 89.4% of accuracy, 74.9% and 38.1% of sensitivity, 81.8% and 72.2% of specificity, and 0.89 and 0.69 of AUC. The model performance was improved with the combination of T1- and T2-weighted MRI images, which was 93.1% of accuracy, 81.6% of sensitivity, 88.7% of specificity, and 0.94 of AUC. 【Conclusions】 The radiomics analysis with T1- and T2-weighted MRI images could highly predict the recurrence of the cervix cancer after radiotherapy. The variation of the distribution and the difference of the pixel number at the peripheral and the center were important predictors.
Modifying the SWAT Model to Simulate Hydrological Processes in Arid and Alpine Grassland Ecosystems
Authors: Jin Xin , Jin Yanxiang 
Published: January 2022

Abstract
Grassland vegetation coverage is spatially heterogeneous in arid and alpine areas due to the terrain, impacts of climate, and anthropogenic activities. Differences in vegetation coverage lead to variations in canopy interception and transpiration ability, which can influence eco-hydrological processes. The Soil and Water Assessment Tool (SWAT) is one of the most widely used semi-distributed catchment-scale eco-hydrological models. The leaf area index (LAI) is one of the vegetation coverage indexes and is incorporated in the SWAT model. However, in SWAT, the LAI is calculated based on the average plant density in hydrologic response units (HRUs). Moreover, LAI accumulation is controlled by heat, and neglects other relevant factors such as precipitation and terrain. To address the drawbacks of the SWAT in simulating vegetation coverage and plant patterns, we modified it using remotely sensed LAI data with high temporal and spatial resolution. We used this to better simulate eco-hydrological processes in grassland basins with different vegetation coverages in the upper reaches of the Bayin River Basin. Site-based streamflow, sediment yield data and remotely sensed actual evapotranspiration data (ET, measured at the subbasin and HRU levels) were used to estimate performances of the original and modified SWAT models. Results showed that for the original SWAT model, the simulated LAI was homogeneous within each land use/cover type, whereas the remotely sensed LAI was spatially heterogeneous and better captured the vegetation coverage of the entire basin. The proper estimation of the LAI was reflected in the improved simulation of the monthly streamflow and sediment yield at the basin outlet and the monthly ET at the subbasins and HRU levels. These findings indicate that the modified SWAT could better simulate hydrological processes in arid and alpine grasslands with different vegetation coverages.
Simultaneous Experimental Analysis of Oil Content and Molecular Composition of Shale Fractions
Authors: Zhang Bowei , Zhang Juhe 
Published: January 2022

Abstract
The important research content and basis of exploration and development is to evaluate the reservoir property, oil bearing property, fluidity and compressibility of shale reservoir.The key of exploration and development is to evaluate the oil-bearing and fluidity of shale reservoir.In this paper, the "shale oil content and fine components synchronous experimental analysis device" is used. Five temperature ranges of 30 ℃-90 ℃, 90 ℃-150 ℃, 100 ℃- 200 ℃, 150 ℃-250 ℃ and 250 ℃-300 ℃ were adopted. The heating rate of each temperature segment was 25 ℃ / min, and the final temperature was kept constant for 5 min. The oil content of shale (pyrolysis S1) was cut into five fractions.Simultaneous determination of oil content and molecular composition of shale fractions,and the external standard method was used to evaluate the oil content and fluidity.The results show that the five fractions of shale are mainly composed of nC1-nC9 gas, nC10-nC15 gasoline, nC12-nC20 kerosene, nC15-nC22 diesel oil and nC18-nC26 heavy oil of the first member of Qingshangkou formation in Songliao basin.There are differences in the fractionation and oil content characteristics of samples with different maturity in different wells.The parent material, properties and quality of crude oil are reflected in shale. The higher the maturity of shale oil is, the more light components are, the larger the light / heavy ratio parameter value of (gasoline + kerosene + diesel) and heavy oil is, the better the fluidity is, and the easier to exploit effectively.
Acute Myocarditis Following the Third Dose of SARS-CoV-2 Vaccine; A Case Report
Authors: Mohammadi Azam , Rezaiye Milad , Goharrizi Mohammad Ali Sheikh Beig 
Published: January 2022

Abstract
BackgroundCOVID-19 pandemic has led to the development and use of the SARS-CoV-2 vaccine. In this study, we report a case with a history of multiple sclerosis that experienced acute Myocarditis following the third dose of the SARS-CoV-2 vaccine. Case presentation A 20-year-old man with a history of multiple sclerosis was admitted to the hospital to visit due to recent retrosternal chest pain four days after the third dose of SARS-COV-2 vaccine (AstraZeneca vaccine). Initial electrocardiogram showed ST-Segment elevation in the inferior limb and precordial leads. However, Echocardiography was normal without any wall motion abnormality. Cardiac Magnetic Resonance (CMR) confirmed acute myocarditis. After treatment and monitoring, Echocardiography, cardiac troponin, CBC, ESR, and CRP were normal, without any symptoms two weeks later. ConclusionsConsequently, vaccine-associated myocardial damage should be considered in the differential diagnosis in patients who have recently been vaccinated against COVID-19. Individuals with chest pain should be monitored regardless of their age and encouraged to perform relevant tests and at least an electrocardiogram.
Mapping and Function Characterization of the Tomato Spotted wilt Virus Resistance Gene SlCHS3 in Solanum Lycopersicum
Authors: Lv Junheng , Deng Minghua , Jiang Shurui , Zhu Haishan , Li Zuosen , Wang Ziran , Li Jing , Yang Zhengan , Yue Yanling , Xu Junqiang , Zhao Kai 
Published: January 2022

Abstract
Tomato spotted wilt virus (TSWV) poses a serious threat to tomato (Solanum lycopersicum) production. In this study, a tomato inbred line YNAU335 was developed without the Sw-5 locus, which showed resistance or immunity to TSWV (absence of infection). Genetic analysis demonstrated that the immunity to TSWV was controlled by a dominant nuclear gene. The candidate genes were mapped into a 20 kb region in the terminal of the long arm of chromosome 9 using the bulk segregant analysis (BSA) and linkage analysis. In this candidate region, a chalcone synthase (CHS)-encoding gene (SlCHS3) was found to be a strong candidate gene for the TSWV resistance. The result showed that SlCHS3 silencing reduced the synthesis of flavonoids, and overexpression of SlCHS3 increased the content of flavonoids. The increased flavonoids could improve the ability of TSWV resistance in the tomato. These findings indicate that SlCHS3 is indeed involved in the regulation of the flavonoids synthesis and play a significant role in the TSWV resistance of YNAU335, it could provide new insights and lay the foundation for analyzing the TSWV resistance mechanisms.
Discovering the Prevalence of Antimicrobial Resistance Through Creation of an Antibiogram in a Rural Kenyan Hospital
Authors: Drobish Ian C , Otieno George , Mihang'o Janet , Barnette Virginia D , Waceke Grace Njoroge , Thuo Solomon , Belknap Kaya S , Linley Katy , Shirk Arianna McLain , McClanahan S Taylor , Irungu Elizabeth , Lelei Faith , Barasa Immaculate K , Brotherton B Jason 
Published: January 2022

Abstract
BackgroundAntimicrobial resistance is a pressing global health issue. Data are lacking in detailing the presence and burden of antimicrobial resistance in low and middle-income countries. What is currently available is quarantined to large, urban centers away from the rural facilities. MethodsThis was a retrospective descriptive study performed at Kijabe Hospital, a rural 350-bed teaching hospital, from February 2016 to September 2020. Cultures from blood, urine, and cerebrospinal fluid were included from all pediatric and adult patients. Data was analyzed and an antibiogram was created using WHONET software. ResultsFrom January 2016 to September 2020 a total of 3275 distinct isolates were identified, including 1654 positive blood cultures, 1288 positive urine cultures, and 91 positive cerebrospinal fluid cultures. Aggregate gram negative susceptibility to third generation cephalosporins was approximately 41%, with 67% of isolates susceptible to piperacillin-tazobactam, and 93% of isolates susceptible to meropenem. The most frequently identified organism was coagulase-negative Staphylococcus (1534, 47%), followed by Escherichia coli (721, 22%), Klebsiella species (482, 15%), and Staphylococcus aureus (110, 3.4%). The most common multidrug resistant organism was Escherichia coli (664, 20%), followed by Klebsiella species (461, 14%). Acinetobacter baumannii was found to be only 57% sensitive to meropenem. Staphylococcus aureus was 91% sensitive to cloxacillin.ConclusionThe high rates of antimicrobial resistance found in this rural referral center were similar to the large urban settings in sub-Saharan Africa. This along with the discovery of multidrug resistant gram negative organisms are of great concern. The need for continued surveillance, antimicrobial stewardship, and implementation of quality improvement initiatives is imperative to attempt to curb this burgeoning global problem.