bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of episodic future thinking on reinforcement pathology during smoking cessation treatment among individuals with substance use disorders
Authors: García-Pérez Ángel , Aonso-Diego Gema , Weidberg Sara , Secades-Villa Roberto 
Published: January 2022

Abstract
Rationale
Reinforcer pathology (RP) is a theoretical model based on two processes: delay discounting (DD) and drug demand. Given that RP has been shown to have a predictive value on smoking behaviors, several studies have explored which interventions can reduce RP. Consistent with the RP framework, episodic future thinking (EFT) has shown effects on treatment outcomes and RP processes. The vast majority of studies that assess the effects of EFT on RP consist of experimental studies, and no previous research has tested these effects in a clinical sample of smokers.

Objectives
The primary aim of this study was to assess the effects of EFT on RP throughout the course of a smoking cessation intervention in smokers with substance use disorders (SUDs).

Methods
Participants were randomized to cognitive behavior therapy (CBT) + EFT (n = 39) or CBT + EFT + contingency management (n = 33). Cotinine, frequency of EFT practices, cigarette purchase task (CPT), and DD were evaluated in treatment sessions. Mixed-effects model repeated measures analysis was used to explore DD and CPT in-treatment changes as a function of EFT practices and cotinine levels.

Results
Greater practice of the EFT component significantly reduced cigarette demand (p < .020) as well as DD (p = .003). Additionally, a greater reduction in cotinine levels coupled with greater EFT practice led to a greater decrease in cigarette demand (p < .014).

Conclusions
EFT reduced the two facets of RP in treatment-seeking smokers with SUDs.
Local administration of epsilon-aminocaproic acid reduces post-operative blood loss from surgery for closed, Sanders III–IV calcaneal fractures
Authors: Zhong Lang , Xu Yangbo , Wang Yongcai , Liu Yu , Huang Qiu 
Published: January 2022

Abstract
Purpose
To investigate whether local administration of epsilon-aminocaproic acid (EACA) is effective and safe in reducing the post-operative blood loss in surgery for Sanders III–IV calcaneal fractures.

Methods
Patients with Sanders III–IV calcaneal fractures who were hospitalized in our hospital from January 2016 to February 2021 and underwent open reduction internal fixation (ORIF) via lateral approach with an L-shaped incision were included in the current study. Eighty five patients were randomly divided into two groups, EACA group (43) and control group (42). Twenty milliliters of 5% EACA solution or normal saline was perfused into the incision of patients in EACA group and control group, respectively. The volume of post-operative drainage was investigated as the primary outcome. Post-operative blood test, coagulation test, and wound complications were analyzed as the secondary outcomes.

Results
The volume of post-operative drainage at 24 and 48 h was 164.8 ± 51.4 ml, 18.9 ± 3.8 ml for patients in EACA group, and 373.0 ± 88.1 ml, 21.2 ± 4.4 ml for patients in the control group, respectively. EACA greatly reduced the post-operative blood loss compared to the control (normal saline). The difference between the two groups was statistically significant. No statistically significant difference was found between EACA group and control group with regard to the pre-operative, baseline characteristics. Post-operative blood test results demonstrated that haemoglobin and hematocrit were significantly higher in EACA compared to those of control group. No significant difference was found between EACA group and control group in terms of the platelet counts, prothrombin time (P.T.), activated partial prothrombin time (APTT), and wound complications.

Conclusion
Local administration of EACA is effective in post-operative blood loss reduction in ORIF surgeries for Sanders III–IV types of calcaneal fractures without increasing the incidence of periwound complication.
Evolution of fluid flow and carbonate recrystallization rates in deep-sea sediments of the Equatorial Pacific
Authors: Wittke Andreas , Gussone Nikolaus , Derigs Dominik , Teichert Barbara M. A. 
Published: January 2022

AbstractFluid flow and carbonate recrystallization rates of deep-sea sediments from eight locations in the Equatorial Eastern Pacific were determined by using δ44/40Ca values of pore water and corresponding sediments. The studied drill sites of IODP Exp. 320/321 are located along a transect of decreasing crustal age and reveal different characteristic pore water depth profiles. The younger sites show an overall isotopic equilibration with the sediment in the upper part of the sedimentary column. In the lower part, the δ44/40Ca of the pore water increases back to seawater-like values at the sediment/basalt interface, forming a bulge-shaped pore water profile. The magnitude of the δ44/40Ca pore water bulge decreases with increasing age of the oceanic crust and sediment cover, resulting in seawater-like δ44/40Ca values throughout the sedimentary column in the oldest Sites U1331 and U1332. These findings indicate a seawater-like fluid input from the underlying crust into the sediment. Thus, after sedimentation, carbonate recrystallization processes start to enrich the pore water in 40Ca, and after a time of carbonate recrystallization and cooling of oceanic crust, a flow of seawater-like fluid starts to move upwards through the sedimentary column, enriching the pore water with 44Ca. We established a carbonate recrystallization and fluid flow model to quantify these processes. Our determined carbonate recrystallization rates between 0.000013e(−t/15.5) and 0.00038e(−t/100.5) and fluid flow rates in the range of 0.42–19 m*Myr−1 indicate that the fluid flow within the investigated sites of IODP Exp. 320/321 depends on the sedimentary composition and location of the specific site, especially the proximity to a recharge or discharge site of a hydrothermal convection cell.
Interannual Influences of the Surface Potential Vorticity Forcing over the Tibetan Plateau on East Asian Summer Rainfall
Authors: Sheng Chen , He Bian , Wu Guoxiong , Liu Yimin , Zhang Shaoyu 
Published: January 2022

AbstractThe influences of interannual surface potential vorticity forcing over the Tibetan Plateau (TP) on East Asian summer rainfall (EASR) and upper-level circulation are explored in this study. The results show that the interannual EASR and associated circulations are closely related to the surface potential vorticity negative uniform leading mode (PVNUM) over the TP. When the PVNUM is in the positive phase, more rainfall occurs in the Yangtze River valley, South Korea, Japan, and part of northern China, less rainfall occurs in southern China, and vice versa. A possible mechanism by which PVNUM affects EASR is proposed. Unstable air induced by the positive phase of PVNUM could stimulate significant upward motion and a lower-level anomalous cyclone over the TP. As a result, a dipole heating mode with anomalous cooling over the southwestern TP and anomalous heating over the southeastern TP is generated. Sensitivity experiment results regarding this dipole heating mode indicate that anomalous cooling over the southwestern TP leads to local and northeastern Asian negative height anomalies, while anomalous heating over the southeastern TP leads to local positive height anomalies. These results greatly resemble the realistic circulation pattern associated with EASR. Further analysis indicates that the anomalous water vapor transport associated with this anomalous circulation pattern is responsible for the anomalous EASR. Consequently, changes in surface potential vorticity forcing over the TP can induce changes in EASR.
BCL3 expression is strongly associated with the occurrence of breast cancer relapse under tamoxifen treatment in a retrospective cohort study
Authors: Czapiewski Piotr , Cornelius Maximilian , Hartig Roland , Kalinski Thomas , Haybaeck Johannes , Dittmer Angela , Dittmer Jürgen , Ignatov Atanas , Nass Norbert 
Published: January 2022

AbstractPatients with estrogen receptor positive breast cancer are usually receiving an anti-estrogen therapy by either aromatase inhibitors or selective estrogen receptor mediators such as tamoxifen. Nevertheless, acquired resistance to tamoxifen under treatment frequently hampers therapy. One proposed explanation for this phenomenon is the interaction of the tumor cells with cells of the tumor microenvironment via the Insulin-like growth factor RNA binding protein 5/B-cell lymphoma 3 (IGFBP5/BCL3) axis. Here we investigated whether a high expression of BCL3 either cytoplasmic or nuclear is associated with the occurrence of a relapse under anti-estrogen therapy in patients. Formaldehyde-fixed, paraffin-embedded samples of 180 breast cancer patients were analyzed for BCL3 expression by immunohistochemistry. An immunoreactive score (IRS) was calculated from staining intensity in cytoplasm and nucleus as well as the percentage of positive tumor cells. These scores were correlated with clinico-pathological parameters using cross-tabulation analysis and patients’ relapse free and overall survival by Kaplan–Meier analysis and Cox regression. A tamoxifen-adapted MCF-7 derived cell line was investigated for BCL3 localization by immunofluorescence. The cytosolic BCL3-IRS significantly correlated with the proliferation marker Ki-67, and with the occurrence of a relapse under tamoxifen treatment. Nuclear score correlated only with tamoxifen-relapse. In survival analysis, both scores were highly significant prognostic factors for relapse free, but not for overall survival. This was especially obvious for estrogen receptor positive and HER2/NEU negative cases as well as lobular breast cancer. Tamoxifen-treated, but not aromatase-treated patients had a poor survival when BCL3 scores were high. A tamoxifen adapted cell line exhibited a reduced expression and mainly nuclear localization of BCL3, compared to the parental estrogen receptor positive cell-line MCF-7. Altogether, these data strongly support a function of BCL3 in tamoxifen resistance and its potential use as a predictive biomarker for tamoxifen resistance.
Neonatal pulmonary hypertension after severe early-onset fetal growth restriction: post hoc reflections on the Dutch STRIDER study
Authors: Pels Anouk , Onland Wes , Berger Rolf M. F. , van Heijst Arno F. J. , Lopriore Enrico , Reiss Irwin K. M. , Limpens Jacqueline , Gordijn Sanne J. , Ganzevoort Wessel 
Published: January 2022

AbstractThe aim was to reflect on the unexpected finding of persistent pulmonary hypertension of the neonate (PPHN) and pulmonary hypertension in infants born within the Dutch STRIDER trial, its definition and possible pathophysiological mechanisms. The trial randomly assigned pregnant women with severe early-onset fetal growth restriction to sildenafil 25 mg three times a day versus placebo. Sildenafil use did not reduce perinatal mortality and morbidity, but did result in a higher rate of neonatal pulmonary hypertension (PH). The current paper reflects on the used definition, prevalence, and possible pathophysiology of the data on pulmonary hypertension. Twenty infants were diagnosed with pulmonary hypertension (12% of 163 live born infants). Of these, 16 infants had PPHN shortly after birth, and four had pulmonary hypertension associated with sepsis or bronchopulmonary dysplasia. Four infants with PPHN in the early neonatal period subsequently developed pulmonary hypertension associated with bronchopulmonary dysplasia in later life. Infants with pulmonary hypertension were at lower gestational age at delivery, had a lower birth weight and a higher rate of neonatal co-morbidity. The infants in the sildenafil group showed a significant increase in pulmonary hypertension compared to the placebo group (relative risk 3.67; 95% confidence interval 1.28 to 10.51,P = 0.02).Conclusion:Pulmonary hypertension occurred more frequent among infants of mothers allocated to antenatal sildenafil compared with placebo. A possible pathophysiological mechanism could be a “rebound” vasoconstriction after cessation of sildenafil. Additional studies and data are necessary to understand the mechanism of action.What is Known:• In the Dutch STRIDER trial, persistent pulmonary hypertension in the neonate (PPHN) was more frequent among infants after antenatal sildenafil exposure versus placebo.What is New:• The current analysis focuses on the distinction between PPHN and pulmonary hypertension associated with sepsis or bronchopulmonary dysplasia and on timing of diagnosis and aims to identify the infants at risk for developing pulmonary hypertension.• The diagnosis pulmonary hypertension is complex, especially in infants born after severe early-onset fetal growth restriction. The research field could benefit from an unambiguous consensus definition and standardized screening in infants at risk is proposed.
Acquired resistance to irradiation or docetaxel is not associated with cross-resistance to cisplatin in prostate cancer cell lines
Authors: Donix Lukas , Erb Holger H. H. , Peitzsch Claudia , Dubrovska Anna , Pfeifer Manuel , Thomas Christian , Fuessel Susanne , Erdmann Kati 
Published: January 2022

Abstract
Purpose
Platinum chemotherapy can be considered to treat metastatic castration-resistant prostate cancer (mCRPC) with features of neuroendocrine differentiation. However, platinum compounds are generally only applied after the failure of multiple prior-line treatment options. This study investigated whether acquired resistance against ionizing radiation or docetaxel chemotherapy—two commonly applied treatment modalities in prostate cancer—influences the cisplatin (CDDP) tolerance in mCRPC cell line models.

Methods
Age-matched parental as well as radio- or docetaxel-resistant DU145 and PC-3 cell lines were treated with CDDP and their sensitivity was assessed by measurements of growth rates, viability, apoptosis, metabolic activity and colony formation ability.

Results
The data suggest that docetaxel resistance does not influence CDDP tolerance in all tested docetaxel-resistant cell lines. Radio-resistance was associated with sensitization to CDDP in PC-3, but not in DU145 cells. In general, DU145 cells tolerated higher CDDP concentrations than PC-3 cells regardless of acquired resistances. Furthermore, non-age-matched treatment-naïve PC-3 cells exhibited significantly different CDDP tolerances.

Conclusion
Like patients, different mCRPC cell lines exhibit significant variability regarding CDDP tolerance. The presented in vitro data suggest that previous radiation treatment may be associated with a moderate sensitization to CDDP in an isogenic and age-matched setting. Therefore, previous radiotherapy or docetaxel chemotherapy might be no contraindication against initiation of platinum chemotherapy in selected mCRPC patients.
Climate variability supersedes grazing to determine the anatomy and physiology of a dominant grassland species
Authors: Bachle Seton , Nippert Jesse B. 
Published: January 2022

AbstractGrassland ecosystems are historically shaped by climate, fire, and grazing which are essential ecological drivers. These grassland drivers influence morphology and productivity of grasses via physiological processes, resulting in unique water and carbon-use strategies among species and populations. Leaf-level physiological responses in plants are constrained by the underlying anatomy, previously shown to reflect patterns of carbon assimilation and water-use in leaf tissues. However, the magnitude to which anatomy and physiology are impacted by grassland drivers remains unstudied. To address this knowledge gap, we sampled from three locations along a latitudinal gradient in the mesic grassland region of the central Great Plains, USA during the 2018 (drier) and 2019 (wetter) growing seasons. We measured annual biomass and forage quality at the plot level, while collecting physiological and anatomical traits at the leaf-level in cattle grazed and ungrazed locations at each site. Effects of ambient drought conditions superseded local grazing treatments and reduced carbon assimilation and total productivity inA. gerardii. Leaf-level anatomical traits, particularly those associated with water-use, varied within and across locations and between years. Specifically, xylem area increased when water was more available (2019), while xylem resistance to cavitation was observed to increase in the drier growing season (2018). Our results highlight the importance of multi-year studies in natural systems and how trait plasticity can serve as vital tool and offer insight to understanding future grassland responses from climate change as climate played a stronger role than grazing in shaping leaf physiology and anatomy.
Disentangling help-seeking and giving up: differential human-directed gazing by dogs in a modified unsolvable task paradigm
Authors: Hirschi Annina , Mazzini Alja , Riemer Stefanie 
Published: January 2022

AbstractDogs are renowned for ‘looking back’ at humans when confronted with a problem, but it has been questioned whether this implies help-seeking or giving up. We tested 56 pet dogs from two breed groups (herding dogs and terriers) in a modified unsolvable task paradigm. One reward type (food or toy) was enclosed in a box, while the respective other reward was accessible. With both reward types, human-directed gazing in relation to the box was significantly positively correlated with interaction with the box, as long as an alternative was available. This suggests that both behaviours served to attain the unavailable reward and reflected individual motivation for the inaccessible vs the accessible reward. Furthermore, we varied whether the owner or the experimenter was responsible for handling the rewards. In the owner-responsible group, dogs rarely gazed at the experimenter. In the experimenter-responsible group, dogs preferentially directed box-related gazing (prior to or after looking at or interacting with the box) at the owner. Still, they gazed at the experimenter significantly longer than the owner-responsible group. Conversely, toy-related gazing was directed significantly more at the experimenter. Thus, dogs adjust their gazing behaviour according to the people’s responsibility and their current goal (help-seeking vs play). Gaze duration did not differ between herding dogs and terriers. We conclude that dogs use gazing at humans’ faces as a social problem-solving strategy, but not all gazing can be classified as such. Dogs’ human-directed gazing is influenced by the social relationships with the persons, situational associations, and context (unsolvable problem vs play).
Exploring cultural differences in wildlife value orientations using student samples in seven nations
Authors: Jacobs Maarten H , Dubois Sara , Hosaka Tetsuro , Ladanović Vukan , Muslim Huda Farhana Mohamad , Miller Kelly K. , Numata Shinya , Ranaweerage E. , Straka Tanja M. , Weston Michael A. , Abidin Zulkhairi Azizi Zainal 
Published: January 2022

AbstractUnderstanding differences in the way people think about wildlife across countries is important as many conservation challenges transcend jurisdictions. We explored differences in wildlife value orientations in seven countries: Australia, Canada, Germany, Japan, Malaysia, the Netherlands and Serbia. Standard scales assessed domination (prioritizing human well-being) and mutualism (striving for egalitarian relationships with wildlife). We used student samples (total n = 2176) for cross-cultural comparisons. Reliabilities of the wildlife value orientations scales were adequate in all countries. Relationships between demographics and wildlife value orientations were different across countries. Men were generally more oriented towards domination and less towards mutualism than women, except in Serbia, where it was the other way around. Estimated at the level of the individual (using ANOVA), wildlife value orientations varied across countries, with nationality explaining a larger portion of the variation in mutualism (21%) than domination (6%). Estimated at the level of countries (using multilevel modelling), effect sizes were comparable. Thought about wildlife has previously only been examined within single countries. This paper makes a new contribution to the conservation literature suggesting that wildlife value orientations vary by country, and are associated with demographic factors. For conservation practices, understanding national differences in the way people think about wildlife is crucial to understanding sources of conflict among practitioners. Such knowledge is also important to gain public support for conservation.
Communicating Reproductive Coercion in the Context of Domestic and Family Violence: Perspectives of Service Providers Supporting Migrant and Refugee Women
Authors: Sheeran Nicola , Tarzia Laura , Douglas Heather 
Published: January 2022

AbstractThe current study explored the language barriers to help-seeking in the context of reproductive coercion and abuse (RCA), domestic and family violence (DFV), and sexual violence (SV), drawing on observations by key informants supporting women from migrant and refugee communities. A lack of shared language has been identified as a key barrier to help seeking for migrant and refugee women experiencing DFV more broadly, though how language intersects with help seeking in the context of RCA is yet to be investigated. We conducted 6 focus groups with 38 lawyers, counsellors, and social workers supporting women experiencing DFV in Brisbane and Melbourne, Australia. Our findings address two main areas. First, consistent with past research in DFV, our participants identified language as a barrier for women when communicating about sexual and reproductive issues in the context of health and police encounters. More specifically, our findings suggest that the inability of health professionals and police to communicate with women who have low or no English proficiency not only negatively impacted victims/survivors’ ability to access support, but also facilitated the perpetration of RCA. We conclude that language can be a mechanism through which coercive control is enacted by perpetrators of RCA and health and policing systems may not be equipped to recognise and address this issue. We also suggest that greater conceptual clarity of RCA is needed within the DFV sector in order to tailor responses.