bluuebunny/crossref_metadata_2025_split huggingface dataset:
Making Data Map Worthy - Enhancing Routine Malaria Data to Support Surveillance and Mapping of Plasmodium Falciparum Antimalarial Resistance in a Pre-Elimination Sub-Saharan African Setting: A Molecular and Spatiotemporal Epidemiology Study
Authors: Kagoro Frank M. , Raman Jaishree , Allen Elizabeth , Mabuza Aaron , Workman Lesley , Magagula Ray , Kok Gerdalize , Davies Craig , Malatje Gillian , Guerin Philippe J , Dhorda Mehul , Maude Richard J , Barnes Karen I. 
Published: February 2022

Abstract
Background: Independent emergence and spread of artemisinin-resistant Plasmodium falciparum malaria has recently been confirmed in Africa, with molecular markers associated with artemisinin resistance increasingly detected. Surveillance to promptly detect and effectively respond to antimalarial resistance is generally suboptimal in Africa, especially in low transmission settings where therapeutic efficacy studies are often not feasible due to recruitment challenges, yet these communities may be at higher risk of antimalarial resistance. Methods: From March 2018 to February 2020, we conducted a sequential mixed-methods study to evaluate the feasibility of the near-real-time linkage of individual patient antimalarial resistance profiles with their case notifications and treatment response reports and map these to fine scales in Nkomazi sub-district, Mpumalanga, a pre-elimination area in South Africa.Results: Plasmodium falciparum molecular marker resistance profiles were linked to 55.1% (2636/4787) of notified malaria cases, 85% (2240/2636) of which were mapped to healthcare facility, ward and locality levels. Over time, linkage of individual malaria case demographic and molecular data increased to 75.1%. No artemisinin resistance validated/associated kelch13 mutations were detected in the 2385 PCR positive samples. Almost all 2812 samples assessed for lumefantrine susceptibility carried the wildtype mdr86ASN and crt76LYS alleles, potentially associated with decreased lumefantrine susceptibility. Conclusion: Routine near-real-time mapping of molecular markers associated with antimalarial drug resistance on a fine spatial scale provides a rapid and efficient early warning system for emerging resistance. The lessons learnt here could inform scale-up to provincial, national and regional malaria elimination programmes, and may be relevant for other antimicrobial resistance surveillance.
Seismic And Geomorphic Assessment For Coseismic Landslides Zonation In Tropical Volcanic Contexts
Authors: Arroyo-Solórzano Mario , Quesada-Román Adolfo , Barrantes-Castillo Gustavo 
Published: February 2022

Abstract
The Poás volcano is an active volcano of Costa Rica with intense tectonic activity in its flanks. Historically, the volcano has presented strong, surficial earthquakes provoking a large number of landslides with associated casualties and immense economic impacts. One example is the Cinchona earthquake in 2009 (Mw 6.2 and 4.6 km depth). We aim to determine a landslide zonation according to seismic data and a geomorphic assessment in the NW sector of the Poás volcano based on a combination of qualitative methods and morphometric parameters. The results estimated the possible outcome of a 6.8 Mw earthquake. The susceptibility mapping and models showed a positive relationship between this methodology and others previously developed for the area that surrounds the Poás volcano as well as a correspondence with the landslides caused by the Cinchona earthquake in 2009. The final zoning coseismic landslides susceptibility indicated that 52% of the area is prone to landslides. Furthermore, there is a relationship between the areas with high exposure to landslides with conical volcanic geomorphologies, active faulting structural and/or tectonic geomorphological units with slopes greater than 15°. The proposed zoning can be useful in land use planning and by the responsible emergency entities to orientate quick response and reduce the impact of future landslides. Moreover, this method can be applied in active tectonic and volcanic areas worldwide.
COVID-19 in adult acute myeloid leukemia patients: a long-term follow-up study from the European Hematology Association survey (EPICOVIDEHA)
Authors: Marchesi Francesco , Salmanton-Garcia Jon , EMARAH Ziad , PIUKOVICS Klára , Nucci Marcio , Lopez-Garcia Alberto , Racil Zdenek , Farina Francesca , POPOVA Marina , ZOMPI Sofia , Audisio Ernesta , Ledoux Marie-Pierre , VERGA Luisa , Weinbergerova Barbora , Szotkowski Tomas , Silva Maria , Fracchiolla Nicola Stefano , DE JONGE Nick , Collins Graham , Marchetti Monia , MAGLIANO Gabriele , GARCÍA-VIDAL Carolina , BIERNAT Monika M. , Doesum Jaap van , MACHADO Marina , Demirkan Fatih , Khabori Murtadha Al , Zak Pavel , Visek Benjamin , STOMA Igor , MÉNDEZ Gustavo-Adolfo , Maertens Johan , KHANNA Nina , Espigado Ildefonso , DRAGONETTI Giulia , Fianchi Luana , Principe Maria Ilaria Del , CABIRTA Alba , ORMAZABAL-VÉLEZ Irati , Jaksic Ozren , BUQUICCHIO Caterina , BONUOMO Valentina , Batinić Josip , OMRANI Ali S. , Lamure Sylvain , Finizio Olimpia , FERNÁNDEZ Noemí , FALCES-ROMERO Iker , BLENNOW Ola , BERGANTIM Rui , Ali Natasha , WIN Sein , PRAET Jens VAN , Tisi Maria Chiara , SHIRINOVA Ayten , SCHÖNLEIN Martin , PRATTES Juergen , PIEDIMONTE Monica , Petzer Verena , NAVRÁTIL Milan , Kulasekararaj Austin , Jindra Pavel , Jiří  , Glenthøj Andreas , FAZZI Rita , de Ramón Cristina , Cattaneo Chiara , CALBACHO Maria , BAHR Nathan C. , EL-ASHWL Shaimaa Saber , Córdoba Raúl , HANAKOVA Michaela , ZAMBROTTA Giovanni , Sciumè Mariarita , Booth Stephen , NUNES-RODRIGUES Raquel , SACCHI Maria Vittoria , GARCÍA-POUTÓN Nicole , MARTÍN-GONZÁLEZ Juan-Alberto , KHOSTELIDI Sofya , GRÄFE Stefanie , RAHIMLI Laman , busca alessandro , Corradini Paolo , HOENIGL Martin , KLIMKO Nikolai , Koehler Philipp , PAGLIUCA Antonio , Passamonti Francesco , Cornely Oliver , pagano Livio 
Published: February 2022

Abstract
Patients with acute myeloid leukemia (AML) are at high risk of mortality from coronavirus disease 2019 (COVID-19). The optimal management of AML patients with COVID-19 has not been established. Our multicenter study included 388 adult AML patients with COVID-19 diagnosis between February 2020 and October 2021. The vast majority were receiving or had received AML treatment in the prior 3 months. COVID-19 was severe in 41.2% and critical in 21.1% of cases. The chemotherapeutic schedule was modified in 174 patients (44.8%), delayed in 68 and permanently discontinued in 106. After a median follow-up of 325 days, 180 patients (46.4%) had died. Death was attributed to COVID-19 (43.3%), AML (26.1%) or to a combination of both (26.7%). Active disease, older age, and treatment discontinuation were associated with death, whereas AML treatment delay was protective. Seventy-nine patients had a simultaneous AML and COVID-19 diagnosis, with an improved survival when AML treatment could be delayed. Patients with COVID-19 diagnosis between January and August 2020 had a significantly lower survival. COVID-19 in AML patients was associated with a high mortality rate and modifications of therapeutic algorithms. The best approach to improve survival was to delay AML treatment.
Optimistic Optimisation of Composite Objective with Exponentiated Update
Authors: Shao Weijia , Sivrikaya Fikret , Albayrak Sahin 
Published: February 2022

Abstract
This paper proposes a new family of algorithms for online optimisation of composite objectives. The algorithms can be interpreted as the combination of exponentiated gradient and $p$-norm algorithm. Combined with algorithmic ideas of adaptivity and optimism, the proposed algorithms achieve a sequence dependent regret upper bound, matching the best known bounds for sparse target decision variables. Furthermore, the algorithms have efficient implementations for popular composite objectives and constraints, and can be converted to stochastic optimisation algorithms with optimal accelerated rate for smooth objectives.
Melting phase relations in Fe-Si-H at high pressure: Implications for Earth’s inner core crystallization and core light elements
Authors: Hikosaka Koutaro , Tagawa Shoh , Hirose Kei , Okuda Yoshiyuki , Oka Kenta , Umemoto Koichiro , Ohishi Yasuo 
Published: February 2022

Abstract
Hydrogen could be an important light element in planetary cores, but its effect on phase diagrams of iron alloys is not well known because the solubility of H in Fe is minimal at ambient pressure and high-pressure experiments on H-bearing systems have been challenging. Considering that silicon can be another major light element in planetary cores, here we performed melting experiments on the Fe-Si-H system at ~50 GPa and obtained the ternary liquidus phase relations and the solid/liquid partition coefficient, D of Si and H based on in-situ high-pressure X-ray diffraction measurements and ex-situ chemical and textural characterizations on recovered samples. Liquid crystallized hexagonal close-packed (hcp) (Fe0.93Si0.07)H0.25, which explains the observed density and velocities of the Earth’s solid inner core. The relatively high DSi = 0.94(4) and DH = 0.70(12) suggest that in addition to Si and H, the liquid outer core includes other light elements such as O, which is least partitioned into solid Fe and can thus explain the density difference between the outer and inner core. H and O, as well as Si, are likely to be major core light elements, supporting the sequestration of a large amount of water in the Earth’s core.
Around-The-Pipe Audio Based Water Tracker for Home Residents
Authors: Rana Ryan 
Published: February 2022

Abstract
Water is one of the most necessary resources within an average household that cannot be quantitatively tracked on a regular basis. There are no methods to this without interfering with the pipeline and flow of water itself. This research presents a revolutionary approach that utilizes audio to measure the amount of water going through a household pipe at any given time with supervised machine learning models. First, different amounts of water were run throughout residential homes with a microphone mounted around the pipe. The output of the microphone is converted into a series of vibrations measured in decibels. The microphone was tested on seven different pipes in 7 different homes to decrease the data bias. It outputs the string of decibel values with a micro-computing device connected to it. The amount of water and received audio is documented into a CSV file with over 100 data points. The data was imported into the Jupyter Notebook and the features (water amount, range of decibels, size of pipe) were scaled and the dataset was split into training and testing subsets at a 70/30 ratio in order to assess the model’s accuracy. Neural Networks, K-Nearest Neighbors, Random Forest, Linear Regression, and Logistic Regression were the five models being used. After all the models were trained and edited to improve hyperparameters, they were compared by testing the data, Neural Networks ended up with the highest classification accuracy at 94.6% as reported by ROC methods.
Restoration of spermatogenesis in azoospermic mice by bone marrow mesenchymal stromal/stem cells conditioned medium
Authors: Zhankina Rano , Afshar Alireza , Farrar Zohreh , Khoradmehr Arezoo , Baghban Mandana , Suleiman Mahmud , Dorvash Mohammad Reza , Baghban Neda , Rahmanifar Farhad , Tanideh Nader , Hosseinabadi Omid Koohi , Monfared Ali Arabi , Zare Shahrokh , Khodabandeh Zahra , Farjam Mojtaba , Nabipour Iraj , Shirazi Reza , Zhanbyrbekuly Ulanbek , Tamadon Amin 
Published: February 2022

Abstract
Background
One of the main cause of male infertility is non-obstructive azoospermia, which is not manageable medically. The first aim of the current research was to show the effect of extracellular vesicle-contained conditioned media (CM) instead of mesenchymal stromal/stem cells (MSCs) for treatment of non-obstructive azoospermia. In the next step, we aimed to study the differentiation potential of MSCs into spermatocytes after injection of MSCs in mice seminiferous tubules. This study has provided an applied treatment for busulfan-induced azoospermia using adipose tissue-derived (AT-MSCs) and bone marrow-derived MSCs (BM-MSCs) and bone marrow CM (BMCM) in animal models.
Methods
Thirty male adult Balb/C mice (30±5 g) and two female eGFP+/+Balb/C mice (30±5 g) were used to design experimental groups and to culture stem cells, respectively. Then, six groups including intact control, azoospermia, AT-MSC therapy, BM-MSC therapy, BMCM therapy, and spontaneous healing groups were considered. All groups except intact control were induced azoospermia by injecting two doses of busulfan (10 mg/kg) with 21 days’ interval. Testes of all mice were removed and studied through histomorphometry and flow cytometry analysis 60 days after treatment.
Results
Histomorphometry and flow cytometry evaluation of testes showed normal morphology of most of the seminiferous tubules of therapy groups as well as successful recovery of spermatogenesis, but spermatogenesis was not observed in the azoospermia group. It is worth notable that the results of the BM-MSC therapy group were more favorable than other therapy groups.
Conclusions
AT-MSC, BM-MSC and BMCM can be strongly suggested as candidates in the therapy of azoospermia.
Testing the bounds of compassion in young children
Authors: Kirby James N. , Wilks Matti , Green Mitchell , Tanjitpiyanond Porntida , Chowdhury Nafisa , Kirkland Kelly , Nielsen Mark 
Published: February 2022

Abstract
Extensive research shows that, under the right circumstances, children are highly prosocial. Less in known about their capacity for compassion. Across five experiments (N = 285), we aimed to capture the bounds of 4-5-year-old children’s compassionate behaviour. In the first three experiments we varied cost of compassion by changing the reward (Study 1), using explicit instructions (Study 2), and ownership (Study 3). In the final two experiments we varied the target of the compassionate behaviour, examining adults compared to puppet targets (Study 4), and whether the target was an in-group member (Study 5). We found strong evidence that cost reduces compassionate responding. By contrast, the recipient of compassion did not appear to influence compassionate responding: children were equally likely to help a human adult and a puppet, and an in-group member and neutral agent. Thus, personal cost appears to be a greater inhibitor to compassionate responding than who compassion is directed toward. These findings demonstrate the factors that may reduce compassionate responding in young children, and call for careful consideration of how to mitigate these to create more positive and socially connected environments for children to flourish.
Cold Gas in Massive Galaxies as A Critical Test of Black Hole Feedback Models
Authors: Shi Jingjing , Peng Yingjie , Diemer Benedikt , Stevens Adam , Pillepich Annalisa , Renzini Alvio , Dou Jing , Gao Yu , Gu Qiusheng , Ho Luis , Kong Xu , Lagos Claudia , Li Di , Li Jiaxuan , Maiolino Roberto , Mannucci Filippo , Xie Lizhi , Zhang Chengpeng 
Published: February 2022

Abstract
Black hole feedback has been widely implemented as the key recipe to quench star formation inmassive galaxies in modern semi-analytic models and hydrodynamical simulations. As the theoreticaldetails surrounding the accretion and feedback of black holes continue to be refined, various feedbackmodels have been implemented across simulations, with notable differences in their outcomes. Yet,most of these simulations have successfully reproduced some observations, such as stellar mass functionand star formation rate density in the local Universe. We use the recent observation on the change ofneutral hydrogen gas mass (including both H2 and Hi) with star formation rate of massive central discgalaxies as a critical constraint of black hole feedback models across several simulations. We nd thatthe predictions of IllustrisTNG agree with the observations much better than the other models testedin this work. This favors IllustrisTNG's treatment of active galactic nuclei - where kinetic winds aredriven by black holes at low accretion rates - as more plausible amongst those we test. In turn, thisalso indirectly supports the idea that the massive central disc galaxy population in the local Universewas likely quenched by AGN feedback.
RSL24D1 sustains steady-state ribosome biogenesis and pluripotency translational programs in embryonic stem cells.
Authors: Durand Sébastien , Bruelle Marion , Bourdelais Fleur , Bennychen Bigitha , Blin Juliana , Isaac Caroline , Huyghe Aurélia , Seyve Antoine , Vanbelle Christophe , Meyronet David , CATEZ Frederic , Diaz Jean-Jacques , Lavial Fabrice , Ricci Emiliano , Ducray François , Gabut Mathieu 
Published: February 2022

Abstract
Embryonic stem cell (ESC) fate decisions are regulated by a complex molecular circuitry that requires tight and coordinated gene expression regulations at multiple levels from chromatin organization to mRNA processing. Recently, ribosome biogenesis and translation have emerged as key pathways that efficiently control stem cell homeostasis. However, the molecular mechanisms underlying the regulation of these pathways remain largely unknown to date. Here, we analyzed the expression, in mouse ESCs, of over 300 genes involved in ribosome biogenesis and we identified RSL24D1 as the most differentially expressed between self-renewing and differentiated ESCs. RSL24D1 is highly expressed in multiple mouse pluripotent stem cell models and its expression profile is conserved in human ESCs. RSL24D1 is associated with nuclear pre-ribosomes and is required for the maturation and the synthesis of 60S subunits in mouse ESCs. Interestingly, RSL24D1 depletion significantly impairs global translation, particularly of key pluripotency factors, including POU5F1 and NANOG, as well as components of the polycomb repressive complex 2 (PRC2). Consistently, RSL24D1 is required for mouse ESC self-renewal and proliferation. Taken together, we show that RSL24D1-dependant ribosome biogenesis is required to both sustain the expression of pluripotent transcriptional programs and silence developmental programs, which concertedly dictate ESC homeostasis.
Systemic COVID-19 vaccination also enhances the humoral immune response after SARS CoV-2 infection in the population of an oncology hospital in Poland. Criteria for COVID-19 re-immunization are needed.
Authors: Kosiorek Piotr , Kazberuk Dorota , Hryniewicz Anna , Milewski Robert , Stróż Samuel , Stasiak-Barmuta Anna 
Published: February 2022

Abstract
Systemic vaccination of the BNT162b2 mRNA stimulates humoral response. Our study aimed to compare the intensity of humoral immune response, measured by SARS CoV-2 IgG, SARS CoV-2 IgM, and neutralization S-RBD IgG antibodies level, post COVID-19 vaccination versus post-SARS CoV-2 infection. We analyzed 1060 people in the following groups: convalescents, healthy vaccinated, vaccinated with Comirnaty, AstraZeneca, Moderna, Johnson & Johnson, and vaccinated SARS CoV-2 convalescents. A concentration of SARS CoV-2 IgG, SARS CoV-2 IgM, and neutralizing S-RBD IgG was estimated in the oncology hospital laboratory by chemiluminescent immunoassay - CLIA, MAGLUMI. Results: 1. We observed a rise of antibodies response in both convalescent SARS CoV-2 and COVID-19 vaccinated groups 2. The level of all antibodies' concentrations in vaccinated COVID-19 convalescents was significantly higher. 3. We differentiated asymptomatic SARS CoV-2 convalescents from the control group. Our analysis suggested that it is essential to monitor SARS CoV-2 IgG antibodies concentrations as an indicator of asymptomatic COVID-19 and equivalent to the effectiveness of humoral response in convalescents and vaccinated people. Considering the time-limited effects of post-infection SARS CoV-2 recovery or vaccination, among others physiological half-life, we suggested monitoring IgG antibodies level as a criterium for the next vaccination.
Evaluation and prediction of water resources carrying capacity in Jiangsu Province, China
Authors: Yan Bing , Xu Yi 
Published: February 2022

Abstract
Water resources carrying capacity (WRCC) is an important component of the carrying capacity of regional natural resources. It is a restrictive index indicating whether a region can support the coordinated development of its population, economy, and environment. In order to solve the problem that WRCC varies with the supporting capacity of, load on, and capacity for regulation of the water resources, this study establishes the relationship between WRCC and the level of socio-economic development (carrying level) and then develops a WRCC evaluation model by analyzing the connotations, characteristics and influencing factors of WRCC. The model is applied to calculate the population and economic scales supportable by water resources in Jiangsu Province under different carrying levels. Predictions are made of the effects of varying water consumption quotas and the industrial structure so as to explore methods of regulating and controlling WRCC in the region. The evaluation, prediction, and control results provide an important reference for the rational allocation of water resources in Jiangsu Province so as to further improve the regional WRCC and achieve sustainable development of regional water resources. The regional WRCC evaluation model has strong applicability and good application effects.
Exploring water-level fluctuation amplitude in an approach channel under the regulation of a dual cascade hydro-plant in the dry season
Authors: Wan Zhiyong , Li Yun , An Jianfeng , Wang Xiaogang , Cheng Long , Liao Yipeng 
Published: February 2022

Abstract
Water-level fluctuation is a crucially important hydraulic factor to meet the safety of ship navigation. Due to the uncertainty and evolution of the maximum amplitude of water-level variation in the approach channel, the river reach between two dams located along the Yangtze River in China is selected as a study area and the impact of various operating conditions of the cascade hydro-plant on the maximum amplitude of water-level variation at typical sites is revealed combining the orthogonal test method and a hydrodynamic model. In addition, the critical threshold for the water-level variation at the lower lock head of the ship lift is explored using maximum entropy method. Results demonstrate that flow variation and regulation time are the most prominent factors affecting water-level fluctuation at the lower lock head of the ship lift, and the existing standard (0.5 m within 1 h and 0.3 m within 30 min) for controlling the maximum variation in water level at the lower lock head of the ship lift is reasonable and more safety oriented. This study provides a novel perspective to understand the response of water-level fluctuation to the stochasticity of operating conditions for the cascade hydropower stations.