bluuebunny/crossref_metadata_2025_split huggingface dataset:
Labour Outcome in Adolescent Pregnancy
Authors: Nessa Kamrun , Chowdhury Shahanara , Malik Adiba , Ara Sarwat , Chowdhury Zinat Ara , Saleh Adnan Bin 
Published: September 2022

Adolescent pregnancy is associated with increased risk of developing complications in both adolescent mother and neonates. It may lead to significant maternal and perinatal mortality and morbidity. To evaluate the labour outcome in adolescent and adult mothers' immediately after delivery and compare the result. A cross sectional comparative study was performed over a period of one year (September 2009- August 2010) at the obstetrics department of Chittagong Medical College Hospital. Consecutive three hundred pregnant mothers admitted for delivery that was fulfilled the inclusion criteria included in study group. Among them 150 were adolescent (13-19yrs) belongs to group A and 150 was adult (20-29 yrs) belongs to group B. Labour outcome (prolonged or obstructed, mode of delivery, stillbirth, birth weight and birth asphyxia were recorded on a preformed questionnaire and statistical analysis done by using SPSS package for windows version 12. Adolescent mother has significant lower mean age at delivery than adults (18.61872 vs. 23.87 = 2.8 yrs. P< 001).Antenatal check up were also (10% vs. 26%, P < 001) infrequent in them. Spontaneous vaginal delivery significantly less (34.7% vs. 48%, P <03) and Caesarean section and instrumental deliveries higher (59.3% vs. 48% & 6% vs. 2.6%.P <03 respectively) in adolescent. Stillbirth and neonatal death also more (3.3% vs. 1.3 & 10% vs. 4.66%, P < 049 respectively) and birth weight less (2.7 kg vs. 2.88 kg, P <0.019) in group A in comparison with group B. Incidence of low birth weight and asphyxia higher in adolescent (12.4% vs. 5.4%, P <03 & 20% vs. 14.9% P<.024). Operative deliveries, stillbirth, birth asphyxia, low birth weight and neonatal death rate significantly higher in adolescent mothers where vaginal delivery significantly less in them in comparison with adult mothers. It indicates that adolescent pregnancy was associated with adverse labour outcome.
JCMCTA 2014 ; 25 (1): 22-26
Prevalence of Modifiable Cardiovascular Risk Factors Among Malaysian Patients With Acute Coronary Syndrome
Authors: Khanom Mehrunnissa , Ahmad Wan Azman Wan 
Published: September 2022

The growing epidemic of coronary heart disease in Asian countries can be prevented and controlled by identification and management of potentially modifiable risk factors. This article provides a single centre statistics of major modifiable risk factors among Malaysian patients presenting with acute coronary syndrome (ACS) and gives a brief discussion on preventive strategies. A single centre, prospective, observational, cohort study model was used. The subjects were patients of 18 years old or above who were admitted to University Malaya Medical Centre (UMMC), Malaysia within January 2009 to December 2010 and recruited under national ACS registry. Among 1525 consecutive ACS patients, 93% had at least one modifiable risk factor and nearly 70% had three or more risk factors. Overall, the prevalence of risk factors in descending order were: hypertension (70%), smoking (47%), diabetes (43%), dyslipidaemia (23%) and Body Mass Index (BMI)>24 (17%). Majority of male patients were smokers (67%) and most of the females were hypertensives (77%). Hypertension was the strongest predictor of mortality among all ACS patients (odds ratio 2.42, 95% CI, (1.43-4.10)]. Identification and primordial prevention of these risk factors are mandatory for prevention of coronary heart disease in the population.
JCMCTA 2014 ; 25 (1): 32-36
Primary Orbital Lymphoma: A Rare Presentation of NHL
Authors: Rabbani Mohammad Golam , Islam Ahmed Tanjimul , Chaudhury Shahed Ahmad , Uddin Jasim , Islam Nazrul , Sultana Shamrin 
Published: September 2022

Non Hodgkins Lymphoma (NHL) is a malignant neoplasm of lymphoid tissue representing 5% of all malignant tumors and one of the commonest haematological malignancy in our country. The disease can involve in any organ commonly in lymph nodes, liver, spleen, brain, eye, testis, thyroid. Orbital lymphoma is comprised about 1% of all NHL. This is a case report of a patient age of 50 years from Daudkandi, Comilla admitted in Chittagong Medical College Hospital with history of gradual non tender swelling in the left eye with no other organ involvement or any B symptoms. The objective of this study to consider orbital lymphoma as differential diagnosis of orbital swelling as it can occur almost any part of the body and is to minimize the delay of diagnosis as well as to improve prognosis. We analyzed the history, examination, investigations & histopathology and immunohistochemistry of orbital growth that showed Non Hodgkin Lymphoma (Low Grade). The Patient was treated with consecutive six cycle R-CHOP (Rituximab, Cyclophosphamide, Adriamycin, Vincristine, Prednisolone) resulting in complete remission of lymphoma.
JCMCTA 2014 ; 25 (1): 41-43
The Risk of Malignancy Index (Rmi) In Preoperative Prediction of Malignancy in a Clinically Suspicious Ovarian Mass
Authors: Noor Serajun , Mahmood Sayed , Akhter Shaheda , Jabin Taniza 
Published: September 2022

There is no satisfactory preoperative tools to differentiate a benign from malignant masses in pelvis. Serum CAl25 level, pelvic ultrasonogram and menopausal status are used individually to predict malignancy with poor outcome but the use of three in association RMI can improve diagnostic performance. Objective:- To evaluate RMI scoring system as method of choice for predicting whether or not an ovarian mass is likely to be malignant. Design:- Cross sectional study. Settings:- Chittagong medical college hospital and Chittagong metropolitan hospital. Duration: January 2011 to October 2014. Sample size:-175 patients admitted in January 2011 to October 2014. The risk malignancy index was calculated as UXMXCA 125 performed preoperatively. Ultrasound findings were scored depending on wall structure, wall thickness and echogenecity (1,4), Menopausal status pre and post menopausal scored as (1,4) and absolute level of CA 125 measured by radioimmunoassay. The individual performance were found in RMI (sen82%, spe 77%, +ve PV 81%, -vePV23, +veLR5.s6, -veL. 53, accuracy 78%), USG (sen86%, spe23%, +vePV87%, vePV32%, +veLR6.5%, veLR.84, accuracy 82%), CAl25 (sen72%, spe32%, +vePV87%, vePV32%, +veLR6.5, veLR. 84, accuracy 67%), Manupausal status (sen84%, spe50%, +vePV21%, -vePV2.4%, +veLR, -veLR, accuracy78%). The area under the ROC curve for risk malignancy index was (.8-.9), which was greater than the area for CAl25 (.6-.7), USG (.7-.8) score and menopausal status (.7-.8). The risk malignancy index using ultrasound morphological score, serum CAl25 level and menopausal status might be of value in the preoperative assessment of ovarian carcinoma.
JCMCTA 2014 ; 25 (2) : 14-20
Incidence, Risk Factor and Pregnancy Outcome Of Preterm Labour: One Year Study In Combined Military Hospital, Chittagong
Authors: Jannat Farhana , Sultana Mahbuba , Nahar Nargis , Jahan Ishrat 
Published: September 2022

Preterm labour & delivery are very challenging obstetric complications encountered by obstetricians. In this study we tried, to determine the incidence, risk factor and pregnancy outcome of patients presenting with preterm labour in Combined Military Hospital. Its a retrospective study in the department of Gynecology & Obstetric, Combined Military Hospital, Chittagong Cantonment from July 2012 to June 2013. Sample size: 116. Inclusion Criteria: Gravid women both primi and multi. Pregnancy of more than 28 weeks duration but less than 37 completed weeks of gestation. Patient is in active labour. Exclusion Criteria: Labour pain started before 28 weeks of pregnancy. Induced preterm labour in any cases like PIH, eclampsia, Preeclampsia, APH, foetal IUGR, etc. Incidence of preterm labour was 22.30% in this study. Preterm rupture of membranes and infection were the commonest causes of preterm labour. Significant risk factor associated with preterm labours in this study are maternal age <20->35 years, low socio-economic condition, lack of proper antenatal care, multiple pregnancy etc. Irrespective of use of a course of steroid neonated mortality was significantly high in babies before 34 weeks. Other perinatal outcomes of preterm labour are birth asphyxia, RDS, neonatal jaundice and septicemia. High incidence of preterm labour being the most serious problem facing our obstetrician. The incidence is higher in our set up, compared to the developed countries. As prevention is naturally best way to combat preterm labour, some modifiable risk factors are identified. Health care provider may encounter maternal age, nutritional status, infection and can identify the target population for betters prenatal care.
JCMCTA 2014 ; 25 (2) : 41-45
Post-cholecystectomy Syndrome Due To Stump-Stones: A Possibility
Authors: Ahmed Jashim Uddin , Alam Kawsar , Uddin Nasir , Hoque Md Nurul , Jabin Taniza 
Published: September 2022

Recurrence of biliary symptoms following cholecystectomy either laparotomic or laparoscopic, is quite common. Causes are either biliary or extra-biliary. Symptoms of biliary origin chiefly depends on residual stones, biliary stricture, rarely depends on stones in cystic duct or gallbladder remnant. Diagnosis of stump-stones is difficult, mainly arising from USG, MRCP,CT-scan, ERCP. Completion cholecystectomy can be done by laparotomy or laparoscopically. We report two cases of stump-stones discovered after 10 years & 5 years following lap chole and minilap cholecystectomy respectively, who were diagnosed by USG, CT-scan and managed by open completion cholecystectomy. Stump-stones can be a possibility of post cholecystectomy syndrome even after 10 years and surgeons should be aware of it.
JCMCTA 2014 ; 25 (2) : 49-53
Gastric Duplication Cyst in a Neonate: A Rare Case Report
Authors: Rahman MA Mushfiqur , Bhuiyan Md Akbar Husain , Chowdhury Tanvir K , Sajid Md Minhajuddin 
Published: September 2022

Among the duplication cysts of Gastro intestinal tract, Gastric duplication is rarer. Here we are reporting a case of gastric duplication cyst in a neonate.
JCMCTA 2014 ; 25 (2) : 57-60
Multiomic analysis revealed the regulatory role of the KRT14 gene in eggshell quality
Authors: Wu Yan , Sun Yanyan , Zhang Hao , Xiao Hongwei , Pan Ailuan , Shen Jie , Pu Yuejin , Liang Zhenhua , Du Jinping , Pi Jinsong 
Published: September 2022

Background: Eggshell strength and thickness are critical factors in reducing the egg breaking rate and preventing economic losses. The calcite biomineralization process is very important for eggshell quality. Therefore, we employed transcriptional sequencing and proteomics to investigate the differences between the uteruses of laying hens with high- and low-breaking-strength shells.Results: A total of 1,028 differentially expressed genes (DEGs) and 270 differentially expressed proteins (DEPs) were identified. The analysis results of GO terms and KEGG pathways showed that most of the DEGs and DEPs were enriched in vital pathways related to processes such as calcium metabolism, hormone and amino acid biosynthesis, and cell proliferation and apoptosis. Several DEGs and DEPs that were coexpressed at mRNA and protein levels were verified. KRT14 (keratin-14) is a candidate gene (protein) obtained by multiple omics analysis due to the fold difference of KRT14 being the largest. After the overexpression of KRT14 in uterine epithelial cells, the expressions of OC116 (ovocleididin-116), CALB1 (calbindin 1), and BST1 (ADP-ribosyl cyclase 2) were found to be increased significantly, while the expression of OC17 (ovocleididin-17) was found to be decreased significantly.Conclusion: In summary, this study confirms that during normal calcification, there are differences in ion transport between the uterus of hens producing high-breaking-strength eggshells and those producing low-breaking-strength eggshells, which may help elucidate the eggshell calcification process. The KRT14 gene may promote calcium metabolism and deposition of calcium carbonate in eggshells.
Keratinocyte-associated protein 3 plays a role in body weight and adiposity with differential effects in males and females
Authors: Szalanczy Alexandria M. , Goff Emily , Seshie Osborne , Deal Aaron , Grzybowski Michael , Klotz Jason , Chuang Key Chia-Chi , Geurts Aron M. , Solberg Woods Leah C. 
Published: September 2022

Despite the obesity crisis in the United States, the underlying genetics are poorly understood. Our lab previously identified Keratinocyte-associated protein 3, Krtcap3, as a candidate gene for adiposity through a genome-wide association study in outbred rats, where increased liver expression of Krtcap3 correlated with decreased fat mass. Here we seek to confirm that Krtcap3 expression affects adiposity traits. To do so, we developed an in vivo whole-body Krtcap3 knock-out (KO) rat model. Wild-type (WT) and KO rats were placed onto a high-fat (HFD) or low-fat diet (LFD) at 6 weeks of age and were maintained on diet for 13 weeks, followed by assessments of metabolic health. We hypothesized that Krtcap3-KO rats will have increased adiposity and a worsened metabolic phenotype relative to WT. We found that KO male and female rats have significantly increased body weight versus WT, with the largest effect in females on a HFD. KO females also ate more and had greater adiposity, but were more insulin sensitive than WT regardless of diet condition. Although KO males weighed more than WT under both diet conditions, there were no differences in eating behavior or fat mass. Interestingly, KO males on a HFD were more insulin resistant than WT. This study confirms that Krtcap3 plays a role in body weight regulation and demonstrates genotype- and sex-specific effects on food intake, adiposity, and insulin sensitivity. Future studies will seek to better understand these sex differences, the role of diet, and establish a mechanism for Krtcap3 in obesity.
Effects of 12 weeks of Tai Chi Chuan intervention on the postural stability and self-reported instability in subjects with functional ankle instability: Study protocol for a randomized controlled trial
Authors: Ke Xiao-hua , Huang Dun-bing , Li Yin-yan , Li Xiao-mei , Guo Jin-hua , Guo Miao-miao , Yu Sheng-xian , Ma Sheng-chao , Jiang Cai , Lin Zhong-hua 
Published: September 2022

BackgroundTai Chi Chuan (TCC) is a physical activity modality that originated in China and is now widely popular around the world. Although there are a series of articles reporting that TCC can improve balance and other functional symptoms in a variety of populations, including the elderly, patients with stroke, and patients with Parkinson's disease, its efficiency has not been scientifically and methodically evaluated in subjects with functional ankle instability (FAI). Moreover, there is no literature directly comparing TCC and conventional balance training (CBT) interventions for FAI. The objective of this study is to investigate the comparative effects of TCC intervention and CBT protocols in improving postural balance and subjective instability feelings in patients with FAI.MethodsThis study will be a single-center, parallel group, randomized controlled trial. Sixty-eight patients with FAI will be included and randomly assigned in a 1:1 ratio to either an intervention group (n =34) or a control group (n = 34). The participants in the intervention group will complete 12 weeks of TCC intervention (40 min/time, 3 times/week for 12 weeks) on the basis of health education treatment. The control group will receive health education and 36 CBT sessions during a 12-week period. Outcome measures include postural stability and self-reported feelings of instability at baseline, after the end of the intervention, and 3-month follow-up. The postural stability assessment of patients with FAI will be detected by performing static and dynamic postural tests, which will be carried out through a specific balance platform (TecnoBody ProKin). Self-reported feelings of instability will be assessed by Cumberland Ankle Instability Tool (CAIT), American Orthopedics Foot and Ankle Society's Ankle–Hindfoot Evaluation Scale (AOFAS-AHES), and the MOS item Short Form Health Survey (SF-36).DiscussionThis trial will demonstrate whether a 12-week TCC intervention positively affects postural stability and self-reported outcomes in patients with FAI. At the same time, the superiority of its clinical efficacy will also be compared with that of CBT. This study may also help to redefine the value of traditional Chinese exercises in the treatment of chronic ankle instability.Clinical trial registrationChinese Clinical Trial Registry: ChiCTR2100041790. Registration date: 22 March 2021. http://www.chictr.org.cn/edit.aspx?pid=119501&amp;htm=4.
Emergency medical service utilization among acute ischemic stroke patients in Beijing: An observational study
Authors: Ding Kexin , Chen Hui , Wang Yong , Liu Hongmei , Ceceke Bayier , Zhang Wei , Geng Ling , Deng Guifang , Sun Tao , Zhang Wenzhong , Wu Yiqun 
Published: September 2022

ObjectiveTo investigate emergency medical service (EMS) utilization and its associated factors in patients with acute ischemic stroke (AIS), and further explore the urban-rural differences.MethodsMedical records for AIS in all emergency departments in Beijing were obtained from the Beijing Emergency Care Database from January 2018 to December 2021. EMS utilization was described and factors associated with EMS use were examined by multivariable logistic regression models with the generalized estimating equations. Results were compared between urban and rural districts.ResultsA total of 24,296 AIS patients were included in the analysis, and 11,190 (46.1%) were transported to hospitals by EMS. The percentage of EMS usage in urban areas was significantly higher than that in rural areas (53.6 vs. 34.4%, P &lt; 0.001). From 2018 to 2021, EMS utilization was on the increase (P-value for trend &lt;0.001) with a higher average annual growth rate in rural areas (12.6%) than in urban (6.4%). Factors associated with EMS utilization were age (OR: 1.20 per 10-year increase, 95% CI: 1.17–1.23), NIHSS scores, off-hour arrival (OR: 1.32, 95% CI: 1.23–1.37), treatment in tertiary hospitals (OR: 1.75, 95% CI: 1.60–1.92), and possessing comorbidities such as coronary artery disease (OR: 1.15, 95% CI: 1.17–1.24), atrial fibrillation (OR: 1.56, 95% CI: 1.41–1.73), prior stroke (OR: 0.84, 95% CI: 0.78-0.90) or dyslipidemia (OR: 0.78, 95% CI: 0.71–0.85).ConclusionThis study demonstrated an inadequate use of EMS among AIS patients in Beijing, especially in rural areas, and revealed several associated factors. Enhanced education programs and EMS accessibility are necessary particularly for high-risk individuals and regions.
The plasma proteome is favorably modified by a high protein diet but not by additional resistance training in older adults: A 17-week randomized controlled trial
Authors: Franzke Bernhard , Bileck Andrea , Unterberger Sandra , Aschauer Rudolf , Zöhrer Patrick A. , Draxler Agnes , Strasser Eva-Maria , Wessner Barbara , Gerner Christopher , Wagner Karl-Heinz 
Published: September 2022

BackgroundThe age-related loss of muscle mass significantly contributes to the development of chronic diseases, loss of mobility and dependency on others, yet could be improved by an optimized lifestyle.ObjectiveThe goal of this randomized controlled trial was to compare the influence of a habitual diet (CON) with either a diet containing the recommended protein intake (RP) or a high protein intake (HP), both with and without strength training, on the plasma proteome in older adults.MethodsOne hundred and thirty-six women and men (65–85 years) were randomly assigned to three intervention groups. CON continued their habitual diet; participants of the HP and RP group consumed either high protein or standard foods. After 6 weeks of dietary intervention, HP and RP groups additionally started a strength training intervention twice per week for 8 weeks. Twenty-four hours dietary recalls were performed every 7–10 days. Body composition was assessed and blood taken. Plasma proteomics were assessed with LC-MS.ResultsParticipants of the HP group doubled their baseline protein intake from 0.80 ± 0.31 to 1.63 ± 0.36 g/kg BW/d; RP increased protein intake from 0.89 ± 0.28 to 1.06 ± 0.26 g/kg BW/d. The CON group kept the protein intake stable throughout the study. Combined exercise and HP initiated notable changes, resulting in a reduction in bodyfat and increased muscle mass. Proteomics analyses revealed 14 significantly affected proteins by HP diet, regulating innate immune system, lipid transport and blood coagulation, yet the additional strength training did not elicit further changes.ConclusionsCombined HP and resistance exercise in healthy older adults seem to induce favorable changes in the body composition. Changes in the plasma proteome due to the high protein diet point to a beneficial impact for the innate immune system, lipid transport and blood coagulation system, all of which are involved in chronic disease development.Clinical trial registrationThe study was registered at ClinicalTrials.gov (NCT04023513).
Analysis of Common Beta-Thalassemia (β-Thalassemia) Mutations in East Java, Indonesia
Authors: Hernaningsih Yetti , Syafitri Yuli , Indrasari Yulia Nadar , Rahmawan Prafa Alif , Andarsini Mia Ratwita , Lesmana Indra , Moses Emmanuel Jairaj , Abdul Rahim Nur Arzuar , Yusoff Narazah Mohd 
Published: September 2022

BackgroundThe frequency of the beta-thalassemia (β-thalassemia) gene in Indonesia ranges from 3 to 10%. However, in the East Java province, there is still limited information on the prevalence of β-thalassemia mutations in clinically diagnosed beta-thalassemia patients of East Java. Therefore, this study aimed to characterize β-thalassemia mutations in selected patients in the East Java province of Indonesia.MethodsThis is an analytical observational study. Diagnosis of β-thalassemia was based on clinical presentation, complete blood count (CBC), and hemoglobin (Hb) electrophoresis. Blood specimens taken from each patient in three ethylenediaminetetraacetic acid (EDTA) tubes were analyzed for CBC and Hb electrophoresis and processed for DNA extraction and subsequent polymerase chain reaction (PCR). Detection of mutations in Hemoglobin Subunit Beta (HBB) gene exons 1–3 of the β-thalassemia gene as the common mutation in Indonesia was done using PCR followed by Sanger sequencing.ResultsIn total, 33 (n = 33) participants were involved in this study with ages ranging from 5 to 17 years comprising 19 women and 14 men. Their ethnic origins were Javanese (n = 30) and Chinese (n = 3). CBC results showed that mean ± standard deviation (SD) for Hb, red blood cell (RBC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and red cell distribution width (RDW)-CV were 81.2 ± 7.0 g/L; 3.40 ± 0.39 × 109/L; 71.05 ± 5.72 fL; 24.12 ± 2.45 pg; 33.91 ± 1.47 g/dl; 24.38 ± 6.02%, respectively. Hb electrophoresis revealed that 5 out of 33 participants had beta-thalassemia and 28 out of 33 participants had hemoglobinopathy (Hb) E/beta-thalassemia. Results of Sanger sequencing showed the following genotype variations in the samples: 12 (36.4%) with βCD26/βIVS−I−5; 6 (18.2%) with βCD26/βCD35; 3 (9.1%) with βCD26/βIVS−I−2; 2 (6.1%) with βCD27/28/βCD40; 2 (6.1%) with βIVS−I−1/βCAP+1; and βCD26/βIVS−I−1; βIVS−I−5/βCAP+1; βIVS−I−5/βCD35; βCD26/βCD37; βCD26/βCD15; βCD26/βCD40; and βIVS−I−5/βCD19 in 1 (3%) sample, respectively, and 1 (3%) had no abnormality detected in sequencing even though electrophoresis showed abnormality in the migration pattern. The βCD26/βIVS−I−5 mutation was found in samples that were noted to have Hb E/beta-thalassemia on Hb electrophoresis.ConclusionThe underlying genetic variations are heterogeneous in thalassemia patients in East Java, where 12 variants were found. The most common variant was βCD26/βIVS−I−5, which all accounted for Hb E/beta-thalassemia on Hb electrophoresis. Furthermore, 28 out of 33 participants had hemoglobinopathy (Hb) E/beta-thalassemia.