bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular Disease (CVD) Risk Assessment of HIV Medication Regimens using hematopoietic CD34+ progenitor cells
Authors: Elzarki Adrian Farid , Nandula Seshagiri Rao , Awal Hassan , Simon Gary L , Sen Sabyasachi 
Published: January 2022

Abstract
Background To determine the effects of integrase inhibitor (INSTI) in comparison to non INSTI based regimens such as non-nucleoside reverse transcriptase inhibitors (NNRTIs) based regimens on cardiovascular disease (CVD) risk in HIV+ patients without overt history of CVD or diabetes, with normal CD4:CD8 count. For CVD risk assessment we primarily used hematopoietic CD34+ progenitor cells, as a biomarker.Methods19 male subjects ages 32-61 years with BMI 21.0- 36.0, were enrolled. This was a single time point, cross-sectional, observational study. Subjects were enrolled under 2 groups (either on INSTI based regimen with 13 subjects or NNRTI (non-INSTI) based regimens with 6 subjects) who were taking stable doses of HAART. The medication regimens were a combination of one NRTI (typically tenofovir-emtricitabine) plus one INSTI or NNRTI. Our outcome measures were focused on cardiovascular and endothelial cell function and systemic inflammation. Our primary outcome measures were peripheral blood derived hematopoietic progenitor cell number (CD34 and CD133 positive), CD34+ cell function and gene expression studies. Our secondary outcomes were arterial stiffness measures and serum-based markers of inflammation. ResultsA significant increase in percentage number of progenitor cells, CD133+ cells (P=0.004) was noted along with an increase of double progenitor mark positive CD133+/CD34+ progenitor cell population was observed in INSTI group as compared to NNRTI group, by flow-cytometry. mRNA gene expression for antioxidant gene catalase was noted along with a trend towards a decrease in gene expression of inflammatory marker IL6 (p=0.06) was observed in CD34+ from INSTI group vs NNRTI group. The plasma IL-6 and CRP levels did not change significantly between the groups. Neutrophil-Lymphocyte ratio (NLR), an important marker of inflammation, was noted to be lower in INSTI group. A mean fasting glucose level was also lower in the INSTI group compared to NNRTI group (p=0.03). Interestingly, Urine- Microalbumin levels were higher in the INSTI group compared to NNRTI group (p=0.08), while eGFR levels were lower in the INSTI group (p=0.002). The arterial stiffness measures did not show statistically significant differences between the two groups. ConclusionWe conclude that the INSTI regimen may provide a better CVD risk profile compared to NNRTI based HAART regimen; however the increased albuminuria along with lower eGFR, noted in INSTI group is of concern. Because of the small size, these results would need replication in additional studies before changing clinical practice.Clinical Trial Registration https://clinicaltrials.gov/ct2/show/NCT03782142?cond=Hiv&spons=Sabyasachi+sen&cntry=US&state=US%3ADC&city=Washington&draw=2&rank=1ClinicalTrials.gov Identifier: NCT03782142
Experiences of Persons Living Schizophrenia in Ghana
Authors: Tetteh Isaac Commey , Ninnoni Jerry PK , Ampofo Evelyn Asamoah , Yeboa Naomi Kyeremaa 
Published: January 2022

Abstract
Living with a chronic condition such as schizophrenia comes with significant challenges. Yet, there is little data on the experiences of people living with schizophrenia in Ghana. This study explored the experiences of persons living with schizophrenia in the Cape Coast Metropolis of Ghana. The study adopted a descriptive phenomenological approach using purposive sampling technique to select nine (9) persons living with schizophrenia for the study. Data was collected using face-to-face in-depth interviews. Interviews were taped, transcribed verbatim, and analysed following Colaizzi’s (1978) descriptive phenomenological data analysis approach. The study revealed that people with schizophrenia maintained their Activities of Daily Living such as washing, sweeping, maintenance of personal and environmental hygiene, so long as they were in their lucid interval. Study participants valued supportive relationship with family members, mental health practitioners, religious institutions and the social networks. Participants reported stigma and lack of job opportunities as some of the major challenges they faced. Non adherence to medication and stigmatization were perceived as common cause of relapse by participants.
Application of Digital Twins to Flexible Production Management: Taking a Shandong Factory as an Example
Authors: Ran Wenxue , Hu Yimin , Zhi Yang 
Published: January 2022

Abstract
By enabling the merging of the virtual and real worlds, DT (Digital Twin) technology has considerably aided the development of businesses at both levels of digitization and networking in recent years. As an outcome, industrial research has shifted its attention to this new technology in the manufacturing business. However, there are still technical issues with DT technology, such as real-time data interaction, high integration of constituent elements, and high simulation. This paper proposes to solve these issues by presenting a framework that blends DT with 3D visualization technologies. A case study of an intelligent logistics management 3D scheduling system for a factory in Shandong verifies the applicability of digital twins to flexible production management. The example demonstrates that the framework can be synchronizing the virtual and real systems. Moreover, the framework can effectively cover the whole manufacturing life cycle, enhance production efficiency and product quality, and achieve flexible production management, helping the manufacturing industry's digital and intelligent transition.
Reference Values and the Z-Score Values of Tricuspid Annular Plane Systolic Excursion in Chinese Children
Authors: Chen Danlei , Guo Jinghui , Liu Bo , Zheng Chunhua , Huang Guimin , Huang Liyi , Zhang Hui , Luo Yi , Wei Dan 
Published: January 2022

Abstract
Objective To establish age-specific and body surface area (BSA)-specific reference values of Tricuspid Annular Plane Systolic Excursion (TAPSE) for children under 15 years old in China. Study design A retrospective study was conducted in Children's Hospital Attached to the Capital Institute of Pediatrics. A total of 702 cases were included in this research to establish reference values of TAPSE. SPSS 25.0 (IBM) was used for data analysis. Lambda-mu-sigma method was used to calculate and construct the age-specific and BSA-specific percentiles and Z-score curves of TAPSE. Results The mean value of TAPSE increased with age and BSA from 0 to 15 years in a nonlinear way and reached the adult level (17mm) until 1 year old. No difference could be observed in genders. Conclusions TAPSE values increased with age and BSA in Chinese children aged between 0-15 years and there was no difference between boys and girls. A multi-center study from different parts of China is supposed to be conducted in the future to reflect the whole spectrum of TAPSE in Chinese children.
The economics of Forest Carbon Sequestration: A Bibliometric Analysis
Authors: Verma Pragati , Ghosh Prashant Kumar 
Published: January 2022

Abstract
Carbon sequestration in forests has increasingly captured the attention of scientists as a strategy for climate change mitigation and environmental sustainability. In this era of huge carbon emission, being a low-carbon and cost-effective technology, the economic analysis of forest carbon sequestration holds higher importance for the successful implementation and intended outcomes. This study elucidates a scientometric view of the research structure and thematic evolution of economic studies on forest carbon sequestration based on 1,439 articles over the time slice 2001-2021. The bibliographic data has been retrieved from the Dimensions database which accommodates a large coverage of research publications and also provides easy access to essential scholarly data and information. Vosviewer and Biblioshiny software tools have opted for visualization and evaluation purposes of bibliometric data. This study employs various measures of bibliometric analysis like co-authorship, bibliographic coupling, citation and keyword analysis to find out the principal articles, authors, journals, most frequent keywords and highest publishing countries and institutions in this field and the results show that the number of publications has escalated substantially in the last five years, Popp A, 2017 (305 citations) and André P C Faaij (11 documents) are the most cited article and the most productive author, respectively, Bradford’s law calculates 21 core journals out of total 503 journals among which Forest Policy and Economics is on the top, and the most productive country and institution are the USA and University of Florida, respectively. The study also investigates key publishing subject categories and the number of publications covered under each Sustainable Development Goals. The overall outcome of this bibliometric study confers an in-depth understanding of the various dimensions of economic analysis on forest carbon sequestration, its development pattern in the last 20 years and also provides emerging themes for future references.
Premorbid Echocardiography And Risk of Hospitalization In COVID-19
Authors: Goel Harsh , Shah Kashyap , Kothari Janish , Daly Timothy , Saraiya Pooja , Taha Israa , Le Marjolein , Shirani Jamshid 
Published: January 2022

Abstract
Background: COVID-19 has caused an unprecedented global pandemic, with cardiovascular risk factors predicting outcomes. We investigated whether baseline trans-thoracic echocardiography could refine risk beyond clinical risk factors. Methods: Symptomatic COVID-19 positive (RT-PCR) adults across St Luke’s University Health Network between March 1st-October 31st 2021, with trans-thoracic echocardiography (TTE) within 15-180 days preceding COVID-19 positivity were selected. Demographic/clinical/echocardiographic variables were extracted from patients’ EHR and compared between groups stratified by disease severity. Logistic regression was used to identify independent predictors of hospitalization. Results: 192 patients were included. 87 (45.3%) required hospitalization, 34 (17.7%) suffered severe disease (need for ICU care/mechanical ventilation/in-hospital death). Age, co-morbidities, and several echocardiographic abnormalities were more prevalent in moderate-severe versus mild disease. On multivariate analysis, age (OR 1.039, 95% CI 1.011-1.067), coronary artery disease (OR 4.184, 95% CI 1.451-12.063), COPD (OR 6.886, 95% CI 1.396-33.959) and left atrial (LA) diameter ≥4.0cm (OR 2.379, 95% CI 1.031-5.493) predicted need for hospitalization. Model showed excellent discrimination (ROC AUC 0.809, 95% CI 0.746-0.873). Conclusion: Baseline LA enlargement independently predicts risk of hospitalization in COVID-19. When available, baseline LA enlargement could identify patients for 1) closer outpatient follow-up, and 2) counseling vaccine-hesitancy.
Comparison of the Respiratory Tractmicrobiome in Hospitalized COVID-19 Patients with Different Disease Severity
Authors: Chen Jiali , Liu Xiong , Liu Wei , Yang Chaojie , Jia Ruizhong , Ke Yuehua , Guo Jinpeng , Jia Leili , Wang Changjun , Chen Yong 
Published: January 2022

Abstract
Background: Little is known about the characteristics of respiratory tract microbiome in Coronavirus disease 2019 (COVID-19) inpatients with different severity. Methods: A cross-sectional study was conducted to characterize respiratory tract microbial communities of 69 COVID-19 inpatients from 64 nasopharyngeal swabs and 5 sputum specimens using 16S ribosomal RNA (rRNA) gene V3-V4 region sequencing. The bacterial profiles were used to find potential biomarkers by the two-step method, the combination of random forest model and the linear discriminant analysis effect size (LEfSe), and explore the connections with clinical characteristics by Spearman’s rank test.Results: Compared with mild COVID-19 patients, severe patients had significantly decreased bacterial diversity (Pvalues were less than 0.05 in the alpha and beta diversity) and relative lower abundance of opportunistic pathogens, including Actinomyces, Prevotella, Rothia, Streptococcus, Veillonella. Eight potential biomarkers including Treponema, Lachnoanaerobaculum, Parvimonas, Selenomonas, Alloprevotella, Porphyromonas, GemellaandStreptococcus were found to distinguish the mild COVID-19 patients from the severe COVID-19 patients. The genera of Actinomyces andPrevotella were negatively correlated with age and inpatient days. Intensive Care Unit (ICU) admission, neutrophil count (GRA) and lymphocyte count (LYMPH) were significantly correlated with different genera in the two groups. In addition, there were a positive correlation between Klebsiella and white blood cell count (WBC) in two groups.Conclusion: The respiratory tract microbiome had significant difference in COVID-19 patients with different severity. The value of the respiratory tract microbiome as predictive biomarkers for COVID-19 severity merits further exploration.
Phylogeography of Nasutitermes ephratae (Termitidae: Nasutitermitinae) in Neotropical region
Authors: Santos Amanda de Faria , Cancello Eliana Marques , Morales Adriana Coletto 
Published: January 2022

Abstract
The neotropical region ranks third in the number of termites with five different families. Of these, Termitidae is the most diverse and includes the species Nasutitermes ephratae and is common in the neotropics. To date, only one study has been published about phylogeographic issues in neotropical termites (N. corniger). Here, we aimed to investigate and analyze the population genetic patterns of N. ephratae and then evaluated the phylogeographical processes involved in the evolutionary history of the species. We used the mitochondrial genes 16S rRNA and COII as molecular markers: These were sequenced for 128 samples of N. ephratae. We estimated the genetic diversity and divergence time as well as the demographic and genetic structure analyses. We also produced ancestral area reconstruction and a haplotype network. The results showed high genetic variability, recent demographic expansion, and strong genetic structure. We also inferred a dispersal route for the species that occurred in both directions between South and Central America. The results emphasize a temporary separation between the South and Central America population that affected the origin of the current Central America populations. These were formed form different phylogeographic histories.
Clinical Analysis of 44 Cases of Atypical Polypoid Adenomyoma of the Uterus
Authors: Wang Xin , Guo Yinshu 
Published: January 2022

Abstract
Background: Atypical polypoid adenomyoma (APA) is a rare intrauterine polypoid lesion that occurs predominantly in premenopausal women. Although, it is considered as a benign lesion and treated conservatively previously, more and more cases show that APA has a high rate of recurrence or residual, and is found to precede the development of carcinoma. The clinical management of APA remains to be established. The aim of this study was to analyse the clinicopathological features of APA and discuss its diagnosis and prognosis.Methods: Forty-four patients with APA were admitted to Beijing Obstetrics and Gynecology Hospital from 2005-2019, and their clinical and histopathologic features were evaluated. B-ultrasound was performed, and all patients (n=44) underwent hysteroscopy. Endometrium excision was performed by means of the “Four-step diagnosis and treatment” method. Hysteroscopic transcervical resection (TCR) was performed in 5 cases with APA-H and 11 with APA-L. Except for one patient who underwent transcervical endometrial resection, all patients underwent hysterectomy and salpingectomy or salpingo-oophorectomy. Data from a median follow-up of 42 months (ranging from 3 to 174 months) were available for these patients.Results: Pathological diagnoses were made according to the degree of abnormality of APA surface glands, resulting in APA-L in 36 cases and APA-H in 8 cases. Among these cases, 28 (25 APA-L and 3 APA-H) were treated conservatively. “Four-step diagnosis and treatment” method performed a excellent effect for APA therapy. During the follow-up no evidence of recurrence was found.Conclusions: For cases with intracavitary lesions > 1 cm, hysteroscopic “four-step diagnosis and treatment” and pathological diagnosis are the basis of clinical treatment. More than 30% of APA surface glands have complex structures, characterized by branching and budding, or other high-risk factors, such as endometrial hyperplasia, which are indications for hysterectomy. For patients with the desire to become pregnant or for uterine preservation, hysteroscopy with complete excision of the lesions should be the preferred treatment method. The patients should be treated individually, followed up closely, and followed up by regular hysteroscopy and endometrial biopsy.
Mutational screening of the TPO and DUOX2 genes in Argentinian children with congenital hypothyroidism due to thyroid dyshormonogenesis.
Authors: Molina Maricel F. , Papendieck Patricia , Sobrero Gabriela , Balbi Viviana A. , Belforte Fiorella S. , Martínez Elena Bueno , Adrover Ezequiela , Olcese María C. , Chiesa Ana Elena , Miras Mirta Beatriz , González Verónica G. , Pio Mauricio Gomes , González-Sarmiento Rogelio , Targovnik Héctor Manuel , Rivolta Carina Marcela 
Published: January 2022

Abstract
Purpose

Primary congenital hypothyroidism (CH) is the most common endocrine disease in children and one of the preventable causes of both cognitive and motor deficits. We present a genetic and bioinformatics investigation of rational clinical design in 16 Argentine patients suspected of CH due to thyroid dyshormonogenesis (TDH).
Methods

Next-Generation Sequencing approach was used to identify variants in Thyroid Peroxidase (TPO) and Dual Oxidase 2 (DUOX2) genes. A custom panel targeting 7 genes associated with TDH [(TPO, Iodothyrosine Deiodinase I (IYD), Solute Carrier Family 26 Member 4 (SLC26A4), Thyroglobulin (TG), (DUOX2), Dual Oxidase Maturation Factor 2 (DUOXA2), Solute Carrier Family 5 Member 5 (SLC5A5)] and 4 associated with thyroid dysembryogenesis [PAX8, FOXE1, NKX2-1, Thyroid Stimulating Hormone Receptor (TSHR)] has been designed. Additionally, bioinformatic analysis and structural modeling were carried out to predict the disease-causing potential variants.
Results

Five novel variants have been identified, two in TPO: c.2749-2A>C and c.2752_2753delAG, [p.Ser918Cysfs*62] and three variants in DUOX2 gene: c.425C>G [p.Pro142Arg]; c.790delC [p.Leu264Cysfs*57] and c.2695delC [p.Gln899Serfs*21]. Seventeen identified TPO, DUOX2 and IYD variants were previously described. We identified potentially pahogenic bi-allelic variants in TPO and DUOX2 in 8 and 2 patients, respectively. We also detected a potentially pathogenic mono-allelic variant in TPO and DUOX2 in 4 and 1 patients respectively. Only two patients were heterozygous for digenic variants in TPO/IYD and in TPO/DUOX2 genes.
Conclusions

22 variants have been identified associated with TDH. All described novel mutations occur in domains important for protein structure and function, predicting the TDH phenotype.
Outer trench slope extension to frontal wedge compression in a subducting plate
Authors: CHANG Emmy Tsui-Yu , Mozziconacci Laetitia 
Published: January 2022

Abstract
Faulting in subducting plates is a critical process that changes the mechanical properties the subducting lithosphere and serves as a carrier of surface materials into mantle wedges. Two intraplate earthquake sequences located in the northern Manila subduction system were investigated in this study, which revealed distinct fault planes but a contrasting seismogeny over the northern Manila Trench. The seismic sequences analyzed in this study were of small-to-moderate events. The events were separately acquired by two ocean-bottom seismometer networks deployed on the frontal accretionary wedge in 2005 and the outer trench slope in 2006. The retrieved seismicity in the frontal wedge (in 2005) mainly included the overpressured sequence, whereas that in the approaching plate (in 2006) was aftershocks of an extensional faulting sequence. The obtained seismic velocity models and Vp/Vs ratios revealed that the overpressure was likely caused by dehydration within the shallow subduction zone. By using the near-field waveform inversion algorithm, we determined focal mechanism solutions for a few relatively large earthquakes. Data from global seismic observations were also used to conclude that stress transfer may be responsible for the seismic activity in the study area in 2005–2006. In late 2005, the plate interface in the frontal wedge area was unlocked by overpressure effect with the thrusting-dominant sequence. This event changed the stress regime across the Manila Trench and triggered the normal fault extension at the outer trench slope in mid-2006. However, the hybrid focal solution indicating reverse and strike-slip mechanisms provided in this study revealed that the plate interface had become locked again in late 2006.
Tuning of Composition and Morphology of LiFePO4 Cathode for Applications in All Solid-State Lithium Metal Batteries
Authors: Harimohan Erabhoina , Thelakkat Mukundan 
Published: January 2022

Abstract
All solid-state rechargeable lithium metal batteries (SS-LMBs) are gaining more and more importance because of their higher safety and higher energy densities in comparison to their liquid-based counterparts. In spite of this potential, their low discharge capacities and poor rate performances limit them to be used as state-of-the-art SS-LMBs. This arise due to the low intrinsic ionic and electronic transport pathways within the solid components in the cathode during the fast charge/discharge processes. Therefore, it is necessary to have a cathode with good electron conducting channels to increase the active material utilization without blocking the movement of lithium ions. Since SS-LMBs require a different morphology and composition of the cathode, we selected LiFePO4 (LFP) as a prototype and, we have systematically studied the influence of the cathode composition by varying the contents of active material LFP, conductive additives (super C65 conductive carbon black and conductive graphite), ion conducting components (PEO and LiTFSI) in order to elucidate the best ion as well as electron conduction morphology in the cathode. In addition, a comparative study on different cathode slurry preparation methods was made, wherein ball milling was found to reduce the particle size and increase the homogeneity of LFP which further aids fast Li ion transport throughout the electrode. The SEM analysis of the resulting calendered electrode shows the formation of non-porous and crack-free structures with the presence of conductive graphite throughout the electrode. As a result, the optimum LFP cathode composition with solid polymer nanocomposite electrolyte (SPNE) delivered higher initial discharge capacities of 114 mAh g-1 at 0.2C rate at 30 ᴼC and 141 mAh g-1 at 1C rate at 70 ᴼC. When the current rate was increased to 2C, the electrode still delivered high discharge capacity of 82 mAh g-1 even after 500 cycle, which indicates that the optimum cathode formulation is one of the important parameters in building high rate and long cycle performing SS-LMBs.