bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge, risk perceptions and practices surrounding chronic inflammatory diseases among first and second generation South Asian immigrants parents and children
Authors: Rishworth Andrea C. , Niraula Ashika , Cao Tiffany , Carrillo Lay Jimena , Ferrari Justin , Zaman Sarah , Wilson Kathi 
Published: May 2022

Purpose
The purpose of this study is to examine knowledge and perceptions of risk surrounding chronic inflammatory diseases (CIDs) and intergenerational development, as well as practices used to acquire CID information among unaffected first- and second-generation South Asian immigrant parents and children in the Greater Toronto Area, Ontario.

Design/methodology/approach
Fifty-four in-depth interviews with parents and children (18 parents, 36 children) were conducted by trained facilitators, recorded, transcribed and analyzed qualitatively.

Findings
Findings reveal that although CIDs disproportionately affect South Asian immigrants, this group has low knowledge and awareness of CID symptoms, risk factors and conditions. Yet when equipped with some knowledge about CIDs, participants linked their increased risk of CIDs to perceived risks in their broader environments such as climate variations, pollution, unhealthy food environments and health system neglect, that although yearning to change these factors, felt unable to modify their risks as factors were beyond their control. Although information is critical to manage CIDs, the findings reveal important and divergent knowledge pathways and practices used among first- and second-generation parents and children, particularly related to health-care settings and academic resources, underscoring generational disparities in knowledge acquisition.

Originality/value
The findings suggest that a multi-sector, multi-tiered approach built around a series of structural interventions, programs and policy changes is needed to address CID knowledge and awareness gaps and entrenched culturally insensitive health care to create more equitable access to healthy, safe and responsive environments and care systems for CID management.
Severe graft‐versus‐host disease‐like enterocolitis accompanied with cytomegalovirus‐reactivation in drug‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms
Authors: Takamiyagi Saeko , Iriki Hisato , Asahina Yasuhiko , Furuichi Yuki , Funakoshi Takeru , Ichikawa Masataka , Mikami Yohei , Okita Hajime , Sakiyama Tomo , Inazumi Toyoko , Amagai Masayuki , Takahashi Hayato 
Published: May 2022

AbstractDrug‐induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe drug adverse reaction with skin eruption and visceral organ involvement. The characteristic clinical features of DIHS/DRESS are reactivation of human herpesviruses (HHV) and the development of autoimmune diseases, but their pathogenesis and associations are not yet understood. Here, we report a 66‐year‐old man who presented with fever, generalized erythema, diffuse lymphadenopathy, and diarrhea after 3 weeks of treatment with zonisamide. Reactivation of HHV‐6 and cytomegalovirus (CMV) was detected during the clinical course. The patient was diagnosed with DIHS/DRESS and treated with systemic prednisolone, i.v. immunoglobulin therapy, and ganciclovir. However, severe enterocolitis persisted for 6 months. A series of examinations revealed features of both CMV enterocolitis, as indicated by identification of a few CMV‐positive cells on immunohistochemical analysis, and graft‐versus‐host disease (GVHD)‐like enterocolitis indicated by orange‐peel appearance on endoscopic examination and histopathological loss of goblet cells. Intractable enterocolitis continued and the patient finally died of pneumonia. An autoimmune predisposition in DIHS/DRESS patients in combination with CMV reactivation was considered to trigger the severe enterocolitis of this case that showed GVHD‐like features of the gastrointestinal tract. GVHD‐like organ damage is a pathological condition rarely observed in DIHS/DRESS but should be recognized as one of the most severe complications of the disease.
China's Global Finance Footprint 2005–2014: Comparing AidData and CGIT
Authors: Ahmed Salma , Rasmussen Bruce , Sheehan Peter 
Published: May 2022

AbstractThe growth of Chinese global official finance has stimulated great interest among foreign aid advocates. Yet, until now, a lack of systematic data reporting has limited our understanding of Chinese official finance. Against this background, this article describes and compares two internationally comparable Chinese datasets from 2005 to 2014: AidData and the China Global Investment Tracker (CGIT). This study summarises China's priority areas of investment and the actual volume of Chinese finance, including a breakdown of these estimates by region and sector. Despite significant disparities between the two databases, this study shows that Chinese investment preferences in terms of locality and priority sectors are broadly consistent with the existing pattern.
The Australian and New Zealand dietetics graduate outcomes survey: A cross‐sectional study
Authors: Blair Merran , Palermo Claire , Gibson Simone , Mitchell Lana 
Published: May 2022

AbstractAimThere is a paucity of comprehensive and current employment data for dietitians. It is unclear if, and where, dietetics graduates are being employed and if they are sufficiently prepared to meet workforce and community needs. The aim of this study was to identify employment outcomes for recent dietetics graduates from Australia and New Zealand at 4–6 months post degree completion.MethodsA cross‐sectional survey was distributed to graduates from accredited dietetics degrees across Australian and New Zealand. Those who completed their university study in 2020 were eligible to participate. Descriptive statistics and frequencies were analysed and open text answers underwent summative content analysis.ResultsA total of 294 usable survey responses were received from 631 eligible graduates (response rate 47%). Seventy‐five percent of graduates were employed in any field and 60% were employed in a role that required their degree. The most common area of dietetics employment was private practice, followed by hospital practice. Most commonly, graduates who did not need their degree to get their job were employed in healthcare‐related roles, or nutrition‐ and food‐related roles.ConclusionsThese findings are important for curricula development to ensure that students are suitably prepared for available employment opportunities. Work‐integrated learning experiences may need to shift focus to skill development, rather than a specific job role, to better prepare graduates for the jobs of the future. Further monitoring of employment outcomes is necessary to track changes over time.
Physico‐chemical properties, antioxidant activity, and ACE inhibitory activity of protein hydrolysates from wild jujube seed
Authors: Han Rongxin , Shao Shuai , Zhang Hongyin , Qi Hongyu , Xiao Fengqin , Shen Yingxin , Fan Lin , Wang Haidong , Zhao Daqing , Li Guangzhe , Yan Mingming 
Published: May 2022

AbstractWild jujube seed protein (WJSP) as one kind of functional food material has attracted much attention due to its highly nutritive and medicinal value in anti‐inflammatory and improving immunomodulatory ability. However, owing to its large molecular weight and complex structure, biological activities of WJSP were greatly limited and cannot be fully utilized by the human body. Therefore, how to improve the bioavailability of WJSP and develop promising WJSP nutritious materials is a great challenge. In this work, wild jujube seed protein hydrolysates (WJSPHs) were prepared from WJSP via enzymatic hydrolysis method, and their physico‐chemical properties, antioxidant activity, and angiotensin converting enzyme (ACE) inhibitory activity in vitro have been investigated for the first time. SDS–PAGE electrophoresis and size–exclusion chromatographic results indicate that WJSPHs have lower molecular weight distribution (< 5,000 Da) than WJSP. Circular dichroism (CD) spectroscopy and Fourier transform infrared spectroscopy (FTIR) results illustrated that random coil is the main secondary structure of WJSPHs. Antioxidant experiments indicate that WJSPHs exhibit high radicals‐scavenging ability of 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radicals (94.60%), 2,2′‐azinobis‐(3‐ethylbenzthiazoline‐6‐sulfonate) (ABTS+) radicals (90.84%), superoxide radicals (44.77%), and hydroxyl radicals (47.77%). In vitro, WJSPHs can significantly decrease the accumulation of reactive oxygen species (ROS) and malondialdehyde (MDA), and increase the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH‐Px) in HepG2 cells. Moreover, ACE activity was found that can be significantly inhibited by WJSPHs (73.02%). Therefore, all previously mentioned results suggest that WJSPHs may be a promising antioxidant food to prevent oxidative‐related diseases in future.Practical ApplicationThis study shows that WJSPHs exhibit high antioxidant activity and ACE inhibitory activity in vitro, which provide potential application value as antioxidant peptides to prevent oxidative‐related diseases.
Consumer search and optimal information
Authors: Dogan Mustafa , Hu Ju 
Published: May 2022

AbstractThis article studies an information design problem in a sequential consumer search environment. Consumers, whose valuation of firms' products is uncertain, observe a noisy signal about the valuation upon being matched with a firm. The goal is to characterize those signal structures that maximize consumer surplus. We show that the consumer‐optimal signal structure can be found within the class of conditional unit‐elastic demand signal distributions. A rich set of properties and comparative statics of the consumer‐optimal signal distributions are also derived.
Elucidating effect of different photosynthetic pigments on Lipaphis erysimi preference and population build‐up on diverse Brassica juncea genotypes
Authors: Samal Ipsita , Singh Naveen , Bhoi Tanmaya K. , Dhillon Mukesh K. 
Published: May 2022

AbstractBrassica juncea is the most important oilseed crop in India, and Lipaphis erysimi is a major pest of this crop. The study aimed at knowing the role of photosynthetic pigments in host preference and population build‐up by L. erysimi on diverse B. juncea genotypes. We found significant differences among test genotypes for aphid preference, multiplication rate and population build‐up, and chlorophyll A, chlorophyll B, total chlorophyll, total carotenoids and Soil Plant Analysis Development (SPAD) chlorophyll and Normalised Difference Vegetation Index (NDVI) values in healthy and aphid damaged flowers, immature siliquae and grain filled siliquae. The L. erysimi damage reduced all the photosynthetic pigments across plant parts of test B. juncea genotypes. The aphid damage resulted in change in chlorophyll B in flowers and total chlorophyll in immature siliquae showed positive association with leaf preference, while total carotenoids in flowers and grain filled siliquae had negative association with leaf and bud preference by L. erysimi. Chlorophylls A and B in the siliquae showed significant and positive association with multiplication rate and population build‐up of L. erysimi on B. juncea. Change in chlorophyll A, total chlorophyll and total carotenoids because of aphid damage contributed to 38.6% variation in host preference and 21.9% variation in multiplication rate and population build‐up of L. erysimi on different B. juncea genotypes. Genotypes PM 30, RH 749, PDZ 6, Pusa 119‐1‐3, Pusa 119‐1‐1 and Kranti were found with least leaf and bud preference, lower aphid multiplication rate and population build‐up, and higher amounts of different chlorophylls and total carotenoids, suggesting their use in aphid resistance breeding programme.
Collaborative inter‐organisational relationships and management control change
Authors: Biswas Sharlene , Akroyd Chris 
Published: May 2022

AbstractThis study examines the changing use of controls to manage an ongoing inter‐organisational collaborative relationship. We do this by studying the development of an open innovation relationship using a case study informed by concepts from neo‐old institutional economics and Simons’ levers of control. Data was collected via semi‐structured interviews and an analysis of documents. Our findings suggest that initially, governance structures and formal safeguards were applied diagnostically, which resulted in low levels of trust. Over time, the development of a collaborative relationship through investments in relational specificity has resulted in a more interactive style of control, which has increased trust.
Crossing at y/our own peril: Biocultural boundary crossing in anthropology
Authors: Cabana Graciela S. , Mendoza Marcela , Smith Lindsay A. , Delfino Hugo , Martínez Carla , Mazza Bárbara , Teruya Rossi Loruhama , Di Fabio Rocca Francisco 
Published: May 2022

AbstractBiocultural approaches in anthropology originated from a desire to dissolve the nature/culture divide that is entrenched in the discipline. Whereas biocultural approaches were born under the umbrella of medical anthropology, by the late 1990s, biology‐centered approaches to bioculturalism had been mostly taken up by human biologists in biological anthropology. It was at this point that biology‐inclined approaches began to gel into an informal interdiscipline, biocultural anthropology. Much like any other discipline, biocultural anthropology developed research and professional norms with erected boundaries around acceptable work and workers. We draw from scholarly work in interdisciplinary studies to explore those norms and boundaries from the perspective of our collaborative, multimethod, and interdisciplinary project that combines “biology” and “culture” in unconventional ways. We provide examples of the obstacles, barriers, and risks we experienced and the costs exacted on the research project and the researchers due to the nature of our boundary crossings. By exploring biocultural anthropology from the edges of acceptability, we expose the unacknowledged boundary work in contemporary biocultural anthropology, and by extension, in its parent discipline, anthropology.
Associations between fetal heart rate variability and umbilical cord occlusions‐induced neural injury: An experimental study in a fetal sheep model
Authors: Ghesquière Louise , Perbet Romain , Lacan Laure , Hamoud Yasmine , Stichelbout Morgane , Sharma Dyuti , Nguyen Sylvie , Storme Laurent , Houfflin‐Debarge Véronique , De Jonckheere Julien , Garabedian Charles 
Published: May 2022

AbstractIntroductionThis study evaluated the association between fetal heart rate variability (HRV) and the occurrence of hypoxic–ischemic encephalopathy in a fetal sheep model.Material and methodsThe experimental protocol created a hypoxic condition with repeated cord occlusions in three phases (A, B, C) to achieve acidosis to pH <7.00. Hemodynamic, gasometric and HRV parameters were analyzed during the protocol, and the fetal brain, brainstem and spinal cord were assessed histopathologically 48 h later. Associations between the various parameters and neural injury were compared between phases A, B and C using Spearman's rho test.ResultsAcute anoxic–ischemic brain lesions in all regions was present in 7/9 fetuses, and specific neural injury was observed in 3/9 fetuses. The number of brainstem lesions correlated significantly and inversely with the HRV fetal stress index (r = −0.784; p = 0.021) in phase C and with HRV long‐term variability (r = −0.677; p = 0.045) and short‐term variability (r = −0.837; p = 0.005) in phase B. The number of neurological lesions did not correlate significantly with other markers of HRV.ConclusionsNeural injury caused by severe hypoxia was associated with HRV changes; in particular, brainstem damage was associated with changes in fetal‐specific HRV markers.
Cord clamping beyond 3 minutes: Neonatal short‐term outcomes and maternal postpartum hemorrhage
Authors: Winkler Andreas , Isacson Manuela , Gustafsson Anna , Svedenkrans Jenny , Andersson Ola 
Published: May 2022

AbstractBackgroundDelaying cord clamping (CC) for 3‐5 minutes reduces iron deficiency and improves neurodevelopment. Data on the effects of CC beyond 3 minutes in relation to short‐term neonatal outcomes and maternal risk of postpartum hemorrhage are scarce.MethodsThis was a prospective observational study performed in two delivery departments. Pregnant women with vaginal deliveries were included. Time to CC, estimated postpartum blood loss, and perinatal data were recorded. Spearman's correlation analysis and comparisons between newborns clamped before and after 3 minutes were performed.ResultsIn total, 904 dyads were included. The mean gestational age ± standard deviation was 40.1 ± 1.2 weeks. CC was performed at a median time of 6 minutes (range 0‐23.5). Apgar scores at 5 and 10 minutes were positively correlated with time to CC (correlation coefficient .140, P < .001 and .161, < .001). There was no correlation between CC time and bilirubin level (correlation coefficient .021, P = .54). The median postpartum blood loss was 300 mL (70‐2550 mL), with a negative correlation between CC time and postpartum blood loss (−0.115, P = .001). The postpartum blood loss was larger in the group clamped at ≤3 minutes (median [interquartile range] 400 mL [300‐600] vs 300 mL [250‐450], [P = .003]].ConclusionsUmbilical CC times beyond 3 minutes in vaginal deliveries were not associated with negative short‐term outcomes in newborns and were associated with a smaller maternal postpartum blood loss. Although CC time as long as 6 minutes could be considered as safe, further research is needed to decide the optimal timing.
In vitro cytotoxicity and docking study of novel symmetric and asymmetric dihydropyridines and pyridines as EGFR tyrosine kinase inhibitors
Authors: Mansour Basem , Bayoumi Waleed A. , El‐Sayed Magda A. , Abouzeid Laila A. , Massoud Mohammed A. M. 
Published: May 2022

AbstractQuinolines have a weighty effect as anticancer agents and 1,4‐DHPs have demonstrated efficacy as anticancer agents in several studies, as well. New hybrid models of symmetric and asymmetric 1,4‐DHPs and pyridines linked at C3 of 2‐chloroquinoline as a new anticancer scaffold, were designed and synthesized. Hantszch 1,4‐DHPs method was adopted for chemical synthesis. MTT assay was performed for the evaluation of cytotoxicity, and EGFR tyrosine kinase assay was performed to investigate binding to our selected compounds, measured by ELISA. The IC50 expressed in µM values revealed that compounds 4a,b, and 5i,k showed the best results against the tested four cell lines than the reference drug 5‐Flurouuracil. Compound 5k displayed the most potent cytotoxic activity with IC50 values in the low µM range (12.03 ± 1.51: 20.09 ± 2.16 µM), compared with 5‐Fu IC50 range (40.74 ± 2.46: 63.81 ± 2.69 µM). The incorporation of 2‐chloroquinoline at C3 to C4 of 1,4‐DHP could be proposed as an anticancer scaffold rather than its analogous pyridines. Ester fragments connected to 1,4‐DHPs ring as a lipophilic part are essential for anticancer activity. The chirality at C4 improved the anticancer activity. The hydrogen and halogen bond facilitated protein‐ligand binding mode and affinity.
Simplification of 2D Polygonal Partitions via Point‐line Projective Duality, and Application to Urban Reconstruction
Authors: Vuillamy J. , Lieutier A. , Lafarge F. , Alliez P. 
Published: May 2022

AbstractWe address the problem of simplifying two‐dimensional polygonal partitions that exhibit strong regularities. Such partitions are relevant for reconstructing urban scenes in a concise way. Preserving long linear structures spanning several partition cells motivates a point‐line projective duality approach in which points represent line intersections, and lines possibly carry multiple points. We propose a simplification algorithm that seeks a balance between the fidelity to the input partition, the enforcement of canonical relationships between lines (orthogonality or parallelism) and a low complexity output. Our methodology alternates continuous optimization by Riemannian gradient descent with combinatorial reduction, resulting in a progressive simplification scheme. Our experiments show that preserving canonical relationships helps gracefully degrade partitions of urban scenes, and yields more concise and regularity‐preserving meshes than common mesh‐based simplification approaches.
A SPoARC of Music: Musicians Spatialize Melodies but not All‐Comers
Authors: Guida Alessandro , Porret Axelle 
Published: May 2022

AbstractRecent studies on the spatial positional associated response codes (SPoARC) effect have shown that when Western adults are asked to keep in mind sequences of verbal items, they mentally spatialize them along the horizontal axis, with the initial items being associated with the left and the last items being associated with the right. The origin of this mental line is still debated, but it has been theorized that it necessitates specific spatial cognitive structures to emerge, which are built through expertise. This hypothesis is examined by testing for the first time whether Western individuals spatialize melodies from left to right and whether expertise in the musical domain is necessary for this effect to emerge. Two groups (musicians and non‐musicians) of participants were asked to memorize sequences of four musical notes and to indicate if a subsequent probe was part of the sequence by pressing a “yes” key or a “no” key with the left or right index finger. Left/right‐hand key assignment was reversed at mid‐experiment. The results showed a SPoARC effect only for the group of musicians. Moreover, no association between pitch and hand responses was observed in either of the two groups. These findings suggest a crucial role of expertise in the SPoARC effect.
Using weather radar to help minimize wind energy impacts on nocturnally migrating birds
Authors: Cohen Emily B. , Buler Jeffrey J. , Horton Kyle G. , Loss Scott R. , Cabrera‐Cruz Sergio A. , Smolinsky Jaclyn A. , Marra Peter P. 
Published: May 2022

AbstractAs wind energy rapidly expands worldwide, information to minimize impacts of this development on biodiversity is urgently needed. Here we demonstrate how data collected by weather radar networks can inform placement and operation of wind facilities to reduce collisions and minimize habitat‐related impacts on nocturnally migrating birds. We found over a third of nocturnal migrants flew through altitudes within the rotor‐swept zone surrounding the North American Great Lakes, a continentally important migration corridor. Migrating birds concentrated in terrestrial stopover habitats within 20‐km from shorelines, a distance well beyond the current guidelines for construction of new land‐based facilities, and their distributions varied seasonally and at local and regional scales, creating predictable opportunities to minimize impacts from wind energy development and operation. Networked radar data are available across the United States and other countries and broad application of this approach could provide information critical to bird‐friendly expansion of this globally important energy source.