bluuebunny/crossref_metadata_2025_split huggingface dataset:
Google classroom como ambiente para a formação continuada de professores: desafios e possibilidades
Authors: Flôres Ana Luiza Zappe Desordi , Lima Quelen Colman Espíndola , Coutinho Cadidja , Ruppenthal Raquel , Marzari Mara Regina Bonini 
Published: January 2022

Este estudo qualitativo de caráter descritivo-exploratório visa relatar a experiência de utilização do Google Classroom como ambiente virtual de aprendizagem para formação continuada de professores, objetivando avaliar o desenvolvimento do curso “Sequências didáticas para promover o Letramento Científico”, as possibilidades e os desafios do uso da plataforma. Para tanto, expõe aspectos conceituais referentes à formação docente e ao uso de tecnologias digitais, em especial a plataforma Google Classroom. Metodologicamente apresenta a proposta do curso estruturada em 6 etapas, a saber: Teorização sobre sequências didáticas; Analisando sequências didáticas diversas; Observando a estrutura básica das sequências didáticas; Produção de uma sequência didática para ser utilizada na sua área de atuação; Retorno/feedback das sequências didáticas; e Avaliação do curso. Como resultados retrata a percepção dos cursistas quanto à temática abordada, a organização das tarefas e dos materiais disponibilizados, bem como os desafios enfrentados no decorrer do curso. Por fim, considera a plataforma Classroom um ambiente virtual de aprendizagem promissor para formação continuada de professores, além de ser um dos principais espaços para organização e gestão do ensino remoto.
Short-distance equivalent test of acquisition, pointing, and tracking process for space laser communication
Authors: Zou Yansheng , Ke Zihao , Shao Yeding , Fan Qirun , Liu Chen 
Published: January 2022

The function and performance of acquisition, pointing, and tracking (APT) for the space laser communication terminals must be characterized on the ground before the launching. However, short working distance causes the terminals to not be viewed as a point, leading to the challenge for the whole-process equivalent test. A novel equivalent test method is proposed, to the best of our knowledge, by using a narrow laser beam and the imaging relationship between two terminals. The communication terminal is transformed to a virtual point by establishing an imaging relationship between the antenna of the transmitter and the tracking detector of the receiver. Thus, the deviation angle between the optical axis of the receiver and the centroid line of two terminals can be measured accurately. Furthermore, the acquisition process of searching the small-size antenna in the receiver with an extensive coverage beam in the transmitter is replaced by searching a large receiver surface with a narrow beam. This point-searching-surface method is equivalent to the surface-searching-point method in actual space communication. With this method, two terminals spaced 5 m apart were employed to construct the short-distance verification platform, and the APT function verification and performance test were completed.
Ultra-precision turning method efficient for optical freeform surfaces with a hybrid slow–fast tool servo
Authors: Lang Changfu , Li Chuang , Fu Hang , Bo Sui , Yang Chao , Xue Changxi 
Published: January 2022

The machining of freeform surfaces is a current research hotspot: A slow tool servo (STS) has limitations in machining accuracy and efficiency for large steep freeform surfaces. Most fast tool servo (FTS) tools are limited by their stroke and cannot manufacture freeform surfaces with a large sag. We propose a hybrid slow–fast tool servo method that combines STS and FTS to machine large steep freeform surfaces by decomposing the freeform surfaces and simultaneously turning efficiently with STS and FTS. Experimental studies were undertaken to fabricate a saddle surface. Meanwhile, a variable feedrates tool path was designed and applied to further improve the machining efficiency. The results show that this method can improve the processing efficiency by 47.5%. The arithmetic mean of surface roughness (Ra) is 2–4 nm, and the peak-to-valley (PV) value is 0.4780 µm at the hollows and 0.3884 µm at the swells.
Immunological and prognostic significance of novel ferroptosis-related genes in soft tissue sarcoma
Authors: Zhao Jiazheng , Zhao Yi , Ma Xiaowei , Feng Helin , Cui Rongmin 
Published: January 2022

Background
Ferroptosis has exhibited great potential in the treatment of cancer and has gained widespread attention in soft tissue sarcoma (STS). The aim was to explore the immunological and prognostic significance of novel ferroptosis-related genes in STS.

Methods
We identified ferroptosis-related differentially expressed genes (DEGs) in STS to construct the networks of enrichment analysis and protein-protein interaction. Subsequently, hub genes with prognostic significance were localized and a series of prognostic and immune analyses were performed.

Results
40 ferroptosis-related DEGs were identified, of which HELLS, STMN1 EPAS1, CXCL2, NQO1, and IL6 were classified as hub genes and were associated with the prognosis in STS patients. In the results of the immune analysis, PDCD1, CTLA4, TIGIT, IDO1 and CD27 exhibited consistent intense correlations as immune checkpoint genes, as well as macrophage, neutrophil, cytotoxic cell, dendritic cell, interdigitating dendritic cell and plasmacytoid dendritic cell as immune cells. EPAS1 and HELLS might be independent prognostic factors for STS patients, and separate prognostic models were constructed by using them.

Conclusions
We recognized novel ferroptosis-related genes with prognostic value in STS. Furthermore, we searched out potential immune checkpoints and critical immune cells.
SUPERVISION FOR ADVOCACY: SUPPORTING SELF-CARE
Authors: FARKAS KATHLEEN J. , ROMANIUK JAROSLAW R. 
Published: January 2022

The objective is to examine the intersection of advocacy for social change, the individual’s emotional costs of advocacy, and the use of trauma informed care in supervisory practice to encourage and support advocates and their work. Supervision models exist, but none address the needs of advocates who might become targets for scorn and persecution. The literature on trauma informed care provides a direction to improve the support and supervision of advocates, especially those who use their personal experiences as examples in their work. We reviewed data bases and relevant literature regarding supervision and the principles of trauma informed care. Periodical literature was reviewed for examples of those affected personally and professionally by their advocacy efforts. Review of the literature revealed little new knowledge on supervision but provided a base to apply the principles of trauma informed care to support and encourage advocacy for social change. This paper suggests the use of trauma informed care in supervisory relationships and advocacy work. This is an original approach to encourage and uphold advocates in difficult times.
Mieloma múltiple IgE: detección y seguimiento
Authors: Nafría Jiménez Beatriz , Oliveros Conejero Raquel 
Published: January 2022

Resumen

Objetivos
Aportar un nuevo caso de mieloma múltiple por inmunoglobulina E (IgE), isotipo muy infrecuente ya que representa <0,1% de todos los pacientes con esta gammapatía monoclonal. Destacar la importancia del estudio de proteínas con una correcta detección, cuantificación e identificación del componente monoclonal, así como las principales consideraciones a tener en cuenta en el laboratorio clínico para un adecuado abordaje.

Caso clínico
Paciente varón de 45 años que, tras presentar dolor intenso en el codo de 5 semanas de evolución, es diagnosticado de mieloma múltiple IgE-Kappa gracias a las pruebas de laboratorio, junto con el análisis radiológico y de la médula ósea. Como tratamiento, el paciente recibe un esquema de inducción quimioterapéutico antes de someterse a un trasplante autólogo de progenitores hematopoyéticos. Actualmente continúa en seguimiento.

Conclusiones
El estudio de proteínas por parte del laboratorio clínico a través del proteinograma y la inmunofijación han permitido detectar un componente monoclonal de tipo IgE-Kappa en un paciente antes de que presentara una sintomatología CRAB (hipercalcemia, afectación renal, anemia y dolor óseo) clásica asociada al mieloma múltiple, ayudando a un diagnóstico y tratamiento precoz.
Variación longitudinal comparativa de los anticuerpos totales, IgG e IgA contra el SARS-CoV-2 en receptores de la vacuna BNT162b2
Authors: Lippi Giuseppe , Salvagno Gian Luca , Henry Brandon M. , Pighi Laura , De Nitto Simone , Gianfilippi Gianluca 
Published: January 2022

Resumen

Objetivos
El objeto del presente estudio es resumir la variación de una amplia serie de anticuerpos contra el SARS-CoV-2 en sujetos receptores de la vacuna de mARN BNT162b2, en un periodo de seis meses.

Métodos
La población del estudio estaba formada por 84 profesionales sanitarios seronegativos al SARS-CoV-2 en situación basal (media de edad: 45 años, 53.6% mujeres), que recibieron la vacuna de mARN denominada BNT162b2. Se tomó una muestra de sangre previamente a la primera y segunda dosis de la vacuna, así como al cabo de 1, 3 y 6 meses. Se determinó el título sérico de los siguientes anticuerpos contra el SARS-CoV-2: anticuerpos totales específicos para el dominio RBD (dominio de unión al receptor), IgG contra la proteína trimérica espicular (Spike), IgG específica para el dominio RBD, e IgA contra el receptor S1 de la proteína trimérica espicular del SARS-CoV-2.

Resultados
Todos los anticuerpos alcanzaron su nivel máximo al mes de recibir la vacunación, pero disminuyeron de forma significativa posteriormente. La tasa media de decrecimiento a los 6 meses fue de −95% para IgG anti- RBD, −85% para IgG contra la proteína trimérica espicular, −73% para IgA anti-S1 y −56% para los anticuerpos totales anti-RBD del SARS-CoV-2, respectivamente. El tiempo medio para la seronegatividad fue de 579 días para los anticuerpos totales anti-RBD SARS-CoV-2, 271 días para IgG contra la proteína trimérica espicular, 264 días para IgG anti-RBD, y 208 días para IgA anti-S1 SARS-CoV-2, respectivamente. A los seis meses, la tasa de sujetos seropositivos se había reducido del 98–100% en el momento de su nivel máximo al 50–100%. La variación entre individuos, en términos de reducción de anticuerpos contra el SARS-CoV-2, a los seis meses fue del 3–44% con respecto al nivel máximo.

Conclusiones
Los resultados de este estudio serológico demuestran que el título de anticuerpos contra el SARS-CoV-2 disminuyó a los seis meses de haber recibido la vacuna BNT162b2, con un periodo medio hasta alcanzar la seronegatividad a los anticuerpos IgG/IgA de 7–9 meses, lo que evidencia la necesidad de administrar dosis de refuerzo a los seis meses, aproximadamente, de la última dosis.
Black pepper (Piper nigrum) fruit-based gold nanoparticles (BP-AuNPs): Synthesis, characterization, biological activities, and catalytic applications – A green approach
Authors: Bawazeer Sami , Khan Ibrahim , Rauf Abdur , Aljohani Abdullah S. M. , Alhumaydhi Fahad A. , Khalil Anees Ahmed , Qureshi Muhammad Nasimullah , Ahmad Laiba , Khan Shahid Ali 
Published: January 2022

Abstract
As compared to conventional techniques, currently nanotechnology has gained significant attention of scientists for the development of plant-based natural nanoparticles (NPs) due to their safety, effectiveness, and environment friendly nature. The current study was aimed for development, characterization (energy-dispersive X-ray, ultraviolet-visible spectroscopy, Fourier-transform infrared spectroscopy, and scanning electron microscopy), and evaluation of the biological efficiency of black pepper (BP; Piper nigrum) fruit-based gold NPs (BP-AuNPs) through different in vitro and in vivo assays. BP extract revealed maximum antibacterial and antifungal potential against Escherichia coli (24 mm) and Aspergillus flavus (47 mm), respectively. However, BP-AuNPs (200 µg·mL−1) inhibited the urease, xanthine oxidase, and carbonic acid-II activities with a percent inhibition of 83.11%, 91.28%, and 86.87%, respectively. Further, the anti-inflammatory effect of BP extract at the dose of 100 mg·kg−1 was 72.66%, whereas for BP-AuNPs it was noticed to be 91.93% at the dose of 10 mg·kg−1. Similarly, the extract of BP and prepared AuNPs demonstrated significant (p < 0.01) sedative effect at all tested doses. The BP-AuNPs catalytically reduced methyl orange dye. Results suggest that BP-AuNPs possess significant biological activities, and further studies must be conducted to identify the probable mechanism of action associated with these activities.
Eco friendly synthesis and characterization of zinc oxide nanoparticles from Aegle marmelos and its cytotoxicity effects on MCF-7 cell lines
Authors: Dhayalan Manikandan , Selvaraj Malathi , Karthick Kumar B , Mohammed Riyaz S.U. , Sillanpää Mika 
Published: January 2022

Abstract
An attempt was made to synthesize zinc oxide gum white nanoparticles (ZnO-GWNPs) by the greenway approach using Aegle marmelos (Bael fruit) juice extract as a capping and reducing agent. Synthesis of ZnO-GWNPs by greener approach is safer, more economical, more energy-efficient, eco-friendlier, and less toxic than chemically synthesized counterparts. The optical properties of the ZnO-GWNPs were ascertained through UV-Vis spectroscopy, Fourier Transform-Infrared (FT-IR), X-ray diffraction (XRD), High-resolution transmittance electron microscopy (HRTEM). A characteristic absorption peak at 385nm confirmed the presence of ZnO-GWNP using UV-Vis spectroscopy. FTIR spectrum revealed that the characteristic absorption peak of the Zn-O bond was observed at 467 cm-1. The XRD result for the ZnO showed the tendency of the three most intense diffraction peaks. The average crystallite size ZnO NPs at scattering angle (2θ) 22.89 and 32.15 was 39.14 and 26.08 nm and it showed the presence of miller indices of (100), (002), (101), (102) respectively. The EDX spectrum gave strong signals for zinc and oxygen indicating the occurrence of the nanoparticles in their oxide form rather than the pure zinc form. The SEM image showed the surface morphology of ZnO-GW NPs and the HR-TEM image showed the crystalline nature of ZnO-GW NPs. Cytotoxicity study of ZnO-GW NPs was determined against MCF-7 cell lines and the IC50 values were found to be 40 µg/mL and 60 µg/mL at 24 h and 48 h respectively.
Dichlorido-{2,6-bis(4,5-dihydro-1H-pyrazol-3-yl)pyridine-κ3
N,N′,N″}zinc(II), C11H9C12N5Zn
Authors: Usman Rabia , Khan Arshad , Khan Amjad , Refat Moamen S. , Alsaedi Amani M. R. , Rahman Faiz-Ur 
Published: January 2022

Abstract
C11H9C12N5Zn, monoclinic, C2/c (no. 15), a = 10.256(3) Å, b = 17.110(5) Å, c = 7.967(3) Å, β = 104.361(4)°, V = 1354.36 Å3, Z = 4, R

gt
(F) = 0.0270, wR
ref(F
2) = 0.0659, T = 293 K.
Organo-catalysis as emerging tools in organic synthesis: aldol and Michael reactions
Authors: Kerru Nagaraju , Maddila Suresh , Jonnalagadda Sreekantha B. 
Published: January 2022

Abstract
Organocatalysis has occupied sustainable position in organic synthesis as a powerful tool for the synthesis of enantiomeric-rich compounds with multiple stereogenic centers. Among the various organic molecules for organocatalysis, the formation of carbon–carbon is viewed as a challenging issue in organic synthesis. The asymmetric aldol and Michael addition reactions are the most significant methods for C–C bond forming reactions. These protocols deliver a valuable path to access chiral molecules, which are useful synthetic hybrids in biologically potent candidates and desirable versatile pharmaceutical intermediates. This work highlighted the impact of organocatalytic aldol and Michael addition reactions in abundant solvent media. It focused on the crucial methods to construct valuable molecules with high enantio- and diastereo-selectivity.
From passive to active sorting in microfluidics: A review
Authors: Zhang Yueyue , Zheng Tingting , Wang Li , Feng Liang , Wang Min , Zhang Zhenchao , Feng Huanhuan 
Published: January 2022

Abstract
Achieving high-efficiency sorting of microfluidics (such as cells, particles, droplets, etc.) has great significance in the fields of biology, chemistry, medical treatment, material synthesis, and drug development. This paper introduces the microfluidics sorting methods in recent years. The current research status and progress can be divided into the active sorting system and passive sorting system according to whether there is an external field. They can control the microfluidics by promoting more selective separation, so as to obtain higher resolution and selection rate. In this paper, the above methods are analyzed and discussed, and the future microfluidic sorting is prospected.
Investigations of polyamide nano-composites containing bentonite and organo-modified clays: Mechanical, thermal, structural and processing performances
Authors: Akar Alinda Oyku , Yildiz Umit Hakan , Tayfun Umit 
Published: January 2022

Abstract
Polyamide 6 (PA) matrix was reinforced with Na-activated bentonite, amino functional silane treated bentonite and organo-modified clays at different concentrations. The preparation of composites was carried out using melt-blending method and the test samples were prepared by injection-molding process. Mechanical, thermal, structural and processing investigations of PA based composites were reported performing via tensile, hardness, and impact tests, differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), scanning electron microscopy (SEM), X-ray diffraction analysis (XRD) and force measurements, respectively. According to mechanical test results, additions of fillers to PA matrix caused slight improvements for tensile strength and modulus parameters. Silane treated BNT exhibited improvement in mechanical results compared to Na-activated bentonite additions. Thermal studies revealed that decomposition and melting temperatures of PA shifted to higher values after inclusion of clay into polymer matrix. Results confirmed that organo-clay and bentonite additions with their lower filling ratios yielded enhancements for the mechanical and thermal performance of polyamide.
Európai Újraélesztési Társaság (ERC) 2021. évi, az emeltszintű újraélesztésről (ALS) és periarrest ritmuszavarok ellátásáról szóló ajánlásának összefoglaló bemutatása
Authors: Tóth Balázs , Pandur Attila , Betlehem József , Priskin Gábor , Schiszler Bence , Radnai Balázs 
Published: January 2022

Jelen referátum célja az Európai Újraélesztési Társaság (European Resuscitation Council, ERC) 2021-ben megjelent(1), a periarrest időszak ellátását is magában foglaló emelt szintű újraélesztési protokolljának összefoglaló bemutatása, hangsúlyozva a korábbi, 2015-ben kiadott protokoll(2) ajánlásaitól való eltéréseket.
Az életet veszélyeztető ritmuszavarok azonnali azonosítása és kezelése alapvető jelentőségű a keringésmegállás megelőzésében, illetve ismétlődésének elkerülése érdekében. A 2021-ben, az ERC által kiadott protokoll igazán jelentős változást a periarrest achycard ritmuszavarok ellátási algoritmusában hozott. Az ellátás főbb terápiás vonala, a korábbi guideline-nal megegyezően, továbbra is a beteg állapotának stabilitása/instabilitása alapján kerül felosztásra.
Az emelt szintű újraélesztés (Advanced Life Support – ALS) többlet beavatkozásokkal kiterjesztett alapszintű újraélesztés (Basic Life Support – BLS). Az ajánlás részletesen taglalja a kórházon belüli és kívüli keringésmegállást, az ezek ellátási lépéseit tartalmazó ALSalgoritmust, a kardiopulmonáris reszuszcitáció (CPR) során végzett légútbiztosítást, gyógyszeres terápiát és annak menedzselését. Ezen irányelvek a Nemzetközi Reszuszcitációs Bizottság (International Liaison Committee on Resuscitation – ILCOR ) által meghatározott ellátási renden alapulnak(3).
ВПЛИВ ІНВЕСТИЦІЙ НА ЕФЕКТИВНІСТЬ ВИКОРИСТАННЯ РЕСУРСНОГО ПОТЕНЦІАЛУ СІЛЬСЬКОГОСПОДАРСЬКИМИ ПІДПРИЄМСТВАМИ
Authors: Ivaniv S.I. 
Published: January 2022

Дослідження спрямоване на детальне вивчення залежності між використанням ресурсного потенціалу сільськогосподарськими підприємствами та залученням інвестицій.
Метою проведення дослідження є вивчення та аналіз впливу різних форм інвестування на діяльність сільськогосподарських підприємств та ефективність використання ресурсного потенціалу.
У дослідженні використовувалася така методологічна база: метод групування для визначення форм залучення інвестицій у сільськогосподарські підприємства; графічний метод для відображення обсягу імпорту нової та вживаної сільськогосподарської техніки, а також динаміки капітальних інвестицій у сільське господарство; метод розрахунку для визначення величини середньорічного абсолютного приросту капітальних інвестицій у сільське господарство; аналітичний метод для визначення стримуючих факторів розвитку інвестиційної діяльності у сільському господарстві.
У статті проаналізовано можливі форми залучення інвестицій та їх вплив на структурні складові ресурсного потенціалу. У результаті дослідження було визначено, що найбільший вплив інвестиційна діяльність має на технічну складову ресурсного потенціалу сільськогосподарських підприємств.
У дослідженні визначено основні чинники, які створюють несприятливий клімат у залученні інвестицій у сільське господарство. Стаття містить рекомендації яким чином варто на державному рівні та на рівні самих сільськогосподарських підприємств підвищувати інвестиційну привабливість сільськогосподарської галузі, особливо якщо йдеться мова про залучення іноземних інвестицій. Продемонстровано динаміку вкладення капітальних інвестицій, де як результат, визначено скорочення інвестицій за останні роки.
Результати, що отримані у ході дослідження можуть використовуватися сільськогосподарськими підприємствами при плануванні використання власного інвестиційного фонду та залучення зовнішніх інвестицій.