bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone Marrow Stromal Stem Cell Fate Decision: A Potential
Mechanism For Bone Marrow Adipose Increase with Aging-related
Osteoporosis
Authors: Tian Li , Lu Lingyun , Meng Yang 
Published: October 2022

Objective:
Osteoporosis is a systemic bone disease that seriously threatens
the health and quality of life in middle-aged and older adults. In this review, we
describe the relationship between bone marrow adipose tissue and aging osteoporosis
and mainly focus on bone marrow mesenchymal stem cell osteogenic-adipose differentiation
fate with aging along with the relevant mechanisms responsible for these
changes.

Methods:
We summarized recent advances in regulating the bone marrow mesenchymal
stem cell differentiation due to aging in this review.

Results:
Aging-related bone mass loss is accompanied by expanding bone marrow
adipose because of an imbalance of bone marrow mesenchymal stem cell differentiation,
resulting in adipogenesis. Ectopic adipocytes in the bone marrow increase with
age and are a key factor responsible for the aging-related bone mass decrease.
Transcription factors and classical regulating pathways are involved in this process
during aging.

Conclusion:
As the global aging population increases, not only older women but also
older men face a great fracture risk. Therefore, finding molecular mechanisms controlling
the stimulating adipogenesis in BMSC during aging is important for providing the
new cue for prevention and therapeutics for aging-related bone loss. Furthermore,
upon physical examination of older people, except for the bone mineral density and
bone turnover biochemical marker, the bone marrow adipose measurement should be
taken into account when assessing the fracture risk and treatment plan that will be
beneficial in clinical practice.
Cerebrospinal Fluid CSF Flow Artifacts are Associated with Brain
Pulsation in Patients with Severe Carotid Artery Stenoses
Authors: Imaizumi Toshio , Nomura Tatsufumi , Komura Shoichi , Inamura Shigeru , Tamada Tomoaki , Kanno Aya , Nonaka Tadashi 
Published: October 2022

Objective:
We investigated the factors associated with cerebrospinal fluid (CSF) flow
artifacts on fluid-attenuated inversion recovery imaging in patients with carotid artery (CA) stenosis.

Methods:
Each CSF artifact grade was defined by comparing the highest intensity in a given region
of interest (ROI) to those in reference ROIs, as follows: higher than the intensity of normal white
matter in the centrum semiovale = 2 points; equal to or less than the white matter, and higher than
CSF = 1 point; and equal to CSF = 0. CSF flow scores in eight sites were measured and added to the
total score (0 -16). The prevalences of each finding, specifically white matter lesions, CA stenoses
and brain atrophy, were compared using multivariate logistic regression models.

Results:
We evaluated the findings in 54 patients with CA stenosis treated by CA stenting (CAS)
and 200 adults with no history of neurological disorders (control group). Adjusted by stroke risk
factors, a CSF flow score ≤ 11 was positively associated with CA stenosis, heart rate > 70 / min, and
brain atrophy, and negatively with the female gender. The score was 12.8 ± 1.8 in the control group
and 12.0 ± 2.0 in CA stenosis group after CAS, which was significantly higher than before CAS
(10.4 ± 2.8, p<0.001).

Conclusions:
The CSF flow score was associated with female gender, brain atrophy, heart rate, and
severe CA stenosis, and was found to be elevated after revascularization.
Electro-acupuncture Promotes Angiogenesis via Exosomal miR-210 in the
Hypoxia-induced HUVECs Mediated HIF-1α/VEGF/Notch 1 Signal Pathway
Authors: Peng Yong-Jun , Xu Shu-Ying , Ni Si-Ming , Zeng Chun-Li 
Published: October 2022

Background:
Acupuncture has been wildly applied for cerebral ischemia treatment in
China for thousands of years, while the specific mechanism remains uncertain. Recently, many studies
have shown that acupuncture promotes angiogenesis after ischemia occurs. Here, we examined
the effect of electro-acupuncture (EA) exosomes on angiogenesis in hypoxia-induced human umbilical
vein endothelial cells (HUVECs).

Objective:
To investigate whether EA exosomal miR-210 promotes angiogenesis in the hypoxiainduced
HUVECs via the HIF-1α/VEGF/Notch 1 signal pathway.

Methods:
The middle cerebral artery occlusion (MCAO) model was established and treated with EA
therapy. Then, exosomes were identified and isolated from rats' plasma in the MCAO+EA group by
transmission electron microscopy (TEM), surface markers expressions, and PKH26 reagent. MiR-
210 mimic, miR-210 inhibitor, and HIF-1α were transfected. Flow cytometry, CCK-8 assay, and
Transwell assay were conducted to assess the migration, apoptosis, and proliferation of each group
of cells. Western blot and quantitative PCR were performed to detect the CD34, HIF-1α, VEGF,
Notch 1, and miR-210 expression levels in each group.

Results:
MiR-210 was significantly upregulated in exosomes of the MCAO plasma, and further
enhanced by EA therapy. EA-EXOs and miR-210 mimic inhibited cell apoptosis, promoted cell
proliferation and cell migration in hypoxia-induced HUVECs. However, the miR-210 inhibitor reversed
the proliferation and migration number induced by EA-EXOs. Besides, EA-EXOs and miR-
210 mimic further enhanced those HIF-1α, VEGF, and Notch 1 levels compared to the hypoxia
treatment only. Silencing HIF-1α or miR-210 reversed the high expressions of those three angiogenic
factors induced by hypoxia and EA-EXO. qPCR showed similar trends with their relative
mRNAs. To analyze these associations quantificationally, Spearman's rank correlation coefficient
was calculated. As revealed by results, the expression of proteins and mRNA were highly correlative
with each other.

Conclusions:
These results indicated that EA-EXO miR-210 promotes angiogenesis in hypoxia conditions
via HIF-1α/VEGF/Notch 1 signal pathway.
Polyphyllin VII as a Potential Drug for Targeting Stemness in Hepatocellular Cancer via STAT3 Signaling
Authors: Li Fangzhou , Xi Xueyan , Xu Liuhang , Chen Ziqi , Wang Yangbin , Li Yulin , Wang Zhongyu 
Published: October 2022

Background:At present, the treatment of hepatocellular carcinoma (HCC) is disturbed by the treatment failure and recurrence caused by the residual liver cancer stem cells (CSCs). Therefore, drugs targeting HCC CSCs should be able to effectively eliminate HCC and prevent its recurrence. In this study, we demonstrated the effect of Polyphyllin VII (PP7) to HCC CSCs, and explored their potential mechanism.Methods:HepG2 and Huh7 cells, were used to analyze the antitumor activity of PP7 by quantifying cell growth and metastasis as well as to study the effect on stemness.Results:Our results demonstrated that PP7 promoted apoptosis and significantly inhibited proliferation and migration of both HepG2 and Huh7 cells. PP7 also inhibited tumor spheroid formation and induced significant changes in the expression of stemness markers (CD133 and OCT-4). These effects of PP7 were mediated by the STAT3 signaling.Conclusion:PP7 can effectively suppress tumor initiation, growth, metastasis, and inhibit stemness through regulation of STAT3 signaling pathway in liver cancer cells. Our data would add more evidence to further clarify the therapeutic effect of PP7 against HCC.
Overexpression of Bromodomain and Extraterminal Domain is Associated with
Progression, Metastasis and Unfavorable Outcomes: Highlighting Prognostic and
Therapeutic Value of the BET Protein Family in Gastric Cancer
Authors: Ghaffari Seyed H. , Fard Shahrzad S. , Kouchaki Shaghayegh , Salimian Zahra , Sotoudeh Masoud , Mousavi Seyed A. , Alimoghaddam Kamran 
Published: October 2022

Background:
As epigenetic readers, Bromodomain and extraterminal domain (BET) proteins have attracted
immense interest in developing novel therapies targeting this family to inhibit cancer progression. Although the impact
of BRD4 in the carcinogenesis of various tumors has been widely investigated, little is known about the potential roles
of the BET family in gastric cancer.

Methods:
In this cohort study, we have screened the expression profile of the BET protein family, including three
members, BRD2, BRD3 and BRD4, in fresh gastric cancer (GC), adjacent non-tumor and normal gastric tissues, as
well as the anti-cancer effects and molecular mechanisms of BET inhibition in GC cell lines.

Results:
Among GC patients, BRD2, BRD3 and BRD4 showed overexpression, 48.07% (25/52), 61.5% (32/52) and
63.46% (33/52), respectively. The overexpression of BRD3 and BRD4 were remarkably associated with unfavorable
outcomes (HR = 2.023, P = 0.038; HR = 3.874, P = 0.001, respectively). However, multivariate Cox regression analysis
indicated that BRDs mRNA expression could not be used as an independent prognostic factor for GC patients after
adjustment with other variables. I-BET151, a potent pan-inhibitor, suppressing the BET family, decreased cell growth,
migration and invasion of GC cells. Interestingly, I-BET151 induced G1 cell cycle arrest through down-regulation of
c-Myc and its target, CDK2/Cyclin D1 complex.

Conclusions:
Our data provide insights into the prognostic role of the BET family in GC and proposed BET inhibition
as a therapeutic strategy for GC patients.
Filter Media Options in Renewable Fuels and Edible Oils
Authors:   Dicalite Management Group, Inc., Galberd Zachary , Appelbaum Eric ,   Dicalite Management Group, Inc.
Published: October 2022

With the additional capacity being brought on in the biofuel space, additional filter media options must be considered. Adding capacity to the North American Diatomaceous Earth (DE) marketplace is a challenge but perlite and cellulose are viable alternatives. Both Biodiesel and Renewable Diesel are derived from fats and oils. These fats and oils can often present processing challenges due to contaminants that interfere with the efficiency of the reaction which need to be treated with adsorbent clays to protect catalyst activity. The use of DE, perlite or cellulose will improve the performance of the leaf filters, which also improves the performance of safety and polish filters. DE is the most well-known filter aid in this space, the use of perlite and cellulose offers many strategic benefits. Perlite offers greater efficiencies and economies than DE when used as a precoat for the treatment of fats and oils. Cellulose although not the most economical option, offers additional benefits that can counter its higher cost. This presentation looks at perlite and cellulose as alternatives to DE and highlight the benefits of each of them.
Quality Assessment of Hypertension Treatment–Related Information on WeChat: Cross-sectional Study
Authors: Yang Yuting , Hou Mengchi , Gong Xue , Guo Rui , Feng Xing Lin , Tian Rui 
Published: October 2022

Background
The WeChat platform has become a primary source for medical information in China. However, no study has been conducted to explore the quality of information on WeChat for the treatment of hypertension, the leading chronic condition.

Objective
This study aimed to explore the quality of information in articles on WeChat that are related to hypertension treatment from the aspects of credibility, concreteness, accuracy, and completeness.

Methods
We searched for all information related to hypertension treatment on WeChat based on several inclusion and exclusion criteria. We used 2 tools to evaluate information quality, and 2 independent reviewers performed the assessment with the 2 tools separately. First, we adopted the DISCERN instrument to assess the credibility and concreteness of the treatment information, with the outcomes classified into five grades: excellent, good, fair, poor, and very poor. Second, we applied the Chinese Guidelines for Prevention and Treatment of Hypertension (2018 edition) to evaluate the accuracy and completeness of the article information with regard to specific medical content. Third, we combined the results from the 2 assessments to arrive at the overall quality of the articles and explored the differences between, and associations of, the 2 independent assessments.

Results
Of the 223 articles that were retrieved, 130 (58.3%) full texts were included. Of these 130 articles, 81 (62.3%) described therapeutic measures for hypertension. The assessment based on the DISCERN instrument reported a mean score of 31.22 (SD 8.46). There were no articles rated excellent (mean score >63); most (111/130, 85.4%) of the articles did not refer to the consequences—in particular, quality of life—of no treatment. For specific medical content, adherence to the Chinese Guidelines for Prevention and Treatment of Hypertension was generally low in terms of accuracy and completeness, and there was much erroneous information. The overall mean quality score was 10.18 (SD 2.22) for the 130 articles, and the scores differed significantly across the 3 types (P=.03) and 5 sources (P=.02). Articles with references achieved higher scores for quality than those reporting none (P<.001). The results from the DISCERN assessment and the medical content scores were highly correlated (ρ=0.58; P<.001).

Conclusions
The quality of hypertension treatment–related information on the WeChat platform is low. Future work is warranted to regulate information sources and strengthen references. For the treatment of hypertension, crucial information on the consequences of no treatment is urgently needed.
Minimal change disease associated with Graves’ disease and methimazole use
Authors: Rodríguez-Gutiérrez Andrés Fernando , Cabezas Sandra Liliana 
Published: October 2022

Introduction. Graves' disease causes kidney injury through multiple mechanisms, including the treatment for this condition. Nephrotic syndrome due to minimal change disease (MCD) is an unusual form of such kidney injury; the association between methimazole use and MCD is also rare.
Case presentation. 36-year-old woman with a history of Graves' disease in use of methimazole for several months, who presented with edematous syndrome due to nephrotic syndrome associated with a KDIGO stage 3 acute kidney injury. Thionamide-induced hypothyroidism and the need of thyroid hormone replacement therapy was evidenced at the time of consultation. Based on a renal biopsy, the patient was diagnosed with MCD. Her condition worsened as she experienced oliguria and hypervolemia, and renal replacement therapy with hemodialysis was temporarily required. Methimazole administration was suspended, and treatment consisting of prednisolone administration and levothyroxine supplementation was started, achieving hemodialysis suspension, gradual improvement of proteinuria until remission and full and maintained recovery of renal clearance. Radioiodine therapy was implemented as definitive treatment for Graves' disease, obtaining a successful outcome.
Conclusions. Graves' disease and methimazole use are possible causes of minimal change disease. Systemic corticosteroid therapy is a possible management. However, further basic, clinical and epidemiological research on this subject is required.
PERTUMBUHAN BIBIT TANAMAN KARET DALAM ROOT TRAINER TERHADAP PEMBERIAN PUPUK ANORGANIK BRIKET
Authors: Putra Riko Cahya , Hidayati Umi 
Published: October 2022

Pemupukan anorganik memegang peranan penting dalam meningkatkan pertumbuhan tanaman karet pada pembibitan root trainer. Pemupukan anorganik pada pembibitan tanaman karet selain diberikan dalam bentuk cair dapat juga diberikan dalam bentuk padat seperti pupuk briket yang memiliki sifat lambat tersedia. Penelitian ini bertujuan untuk mengetahui pertumbuhan tanaman karet pada pembibitan root trainer terhadap pemberian pupuk anorganik briket. Penelitian dilaksanakan di kebun percobaan Unit Riset Bogor-Getas, Salatiga, Jawa Tengah pada bulan April sampai September 2020. Rancangan percobaan yang digunakan adalah Rancangan Acak Lengkap dengan 8 perlakuan dan 6 ulangan. Perlakuan terdiri atas: 1)kontrol tanpa pemupukan; 2)pupuk cair 2 minggu; 3)briket 5 g/tanaman; 4)briket 10 g/tanaman; 5)briket 5 g/tanaman + pupuk cair 2 minggu; 6)briket 10 g/tanaman + pupuk cair 2 minggu; 7)briket 5 g/tanaman + pupuk cair 4 minggu; 8)briket 10 g/tanaman + pupuk cair 4 minggu. Pemberian pupuk anorganik briket tidak menunjukkan peningkatan pertumbuhan tinggi tanaman, diameter batang, bobot akar, bobot tanaman, dan kandungan hara daun dibandingkan tanpa pemupukan. Efektivitas agronomi relatif tertinggi ditunjukkan pada perlakuan briket 10 g/tanaman + pupuk cair 4 minggu dengan RAE 145%. Hal tersebut berarti bahwa penambahan pupuk anorganik briket 10 g/tanaman dapat mengurangi frekuensi pupuk cair dengan efektivitas agronomi relatif yang sudah lebih tinggi 45% dibandingkan pupuk cair 2 minggu.
Kata kunci: pupuk briket; pupuk cair; pembibitan karet; root trainer
PEDAGOGIA FEMINISTA: DAS NOVAS PRÁTICAS DE MATERNAGEM À EDUCAÇÃO ESCOLAR LIBERTÁRIA
Authors: Lemes Luana Borges , Lemes Mariana Borges 
Published: October 2022

Esta pesquisa objetiva relacionar as narrativas de maternagem feminista de mães entrevistadas e as práticas pedagógicas voltadas à diversidade sociocultural nas escolas a partir de revisão bibliográfica sobre aprendizagem e equidade de gênero. A partir de entrevistas, identificam-se novas práticas de maternagem voltadas à equidade de gênero atribuídas às militâncias feministas e a educação das crianças com diálogos reflexivos e questionamentos acerca do sexismo, para fomentar relações igualitárias de gênero, sexualidade e diversidade sociocultural. Nessa educação há uma intrínseca valorização dos direitos humanos nas relações familiares, escolares e no entorno social, que ratifica a pedagogia crítica feminista, que neste estudo agrega às práticas escolares o combate do sexismo nas infâncias, a fim de contribuir à formação de caráter e de cidadania dos(das) estudantes com equidade de gênero, desconstruindo preconceitos e ampliando possibilidades às crianças e aos planos pedagógicos.
Postoperative pregnancy outcome prediction model based on 3-dimensional ultrasound for intrauterine adhesion
Authors: Zhao Xingping , Zhang Baiyun , zhang baiyu , shu changfa , zhou zengzi , Sun Dan , Yang Yimin , Burjoo Arvind , Xu Dabao 
Published: October 2022

Objective: The aims of this study were to establish a mathematical model
to predict intrauterine adhesion (IUA) prognosis based on 3-dimensional
(3D) ultrasound. Design：Derivate retrospectively and validate
prospectively. Setting: University affiliated hospitals Population: 668
IUA in the derivation cohort and 426 IUA in the validation cohort.
Methods: Logistic regression analysis was used to develop prediction
models to forecast the live birth rate following HA according to
postoperative 3D-TVUS characteristics and hysteroscopy characteristics.
The performance of each of the prediction models was compared by
calculating the area under the curve (AUC). A nomogram was then
constructed for the excellent model. Main Outcome Measures: General
clinical information, 3D-TVUS characteristics and hysteroscopy
characteristics. Results: Live birth was achieved by 242 IUA patients in
the derivation cohort (n = 668) and by 150 in the validation cohort
(n = 426). Logistic regression analysis revealed that the AUC for the
models based on 3D-TVUS characteristics in the derivation and validation
cohorts were 0.8506 and 0.8963, respectively, which was better than the
models based on hysteroscopy characteristics. The calibration curve of
the nomogram based on 3D-TVUS characteristics and a non-significant
Hosmer–Lemeshow test statistic showed good calibration (P = 0.3064).
Conclusion: Our findings indicate that postoperative 3D ultrasound
characteristics could be predictive factors for live births among IUA
patients and provide valuable reproductive guidance for women after HA.
Reducing Strategy Surrogation: The Effects of Performance Measurement System Flexibility and Environmental Dynamism
Authors: Wang Kelly K. , Cheng Mandy M. , Chang Linda J. 
Published: October 2022

ABSTRACT
Prior research shows that individuals exhibit a propensity to surrogate performance measures for their underlying strategy, resulting in suboptimal strategic decisions. We investigate whether the incorporation of flexibility in contemporary performance measurement systems (PMSs) reduces surrogation propensity in the context of product innovation and whether this effect varies depending on environmental dynamism. We conduct a 2 × 2 experiment and find that PMS flexibility significantly lowers managers' surrogation propensity when the business environment is more dynamic and when the investment decisions have opportunity costs. Our study contributes to the literature by identifying a viable way to reduce managers' surrogation propensity.
Diabetes-related excess mortality in Mexico: a comparative analysis of national death registries between 2017-2019 and 2020
Authors: Bello-Chavolla Omar Yaxmehen , Antonio-Villa Neftali Eduardo , Fermín-Martínez Carlos A. , Fernández-Chirino Luisa , Vargas-Vázquez Arsenio , Ramírez-García Daniel , Basile-Alvarez Martín Roberto , Hoyos-Lázaro Ana Elena , Carrillo-Larco Rodrigo M. , Wexler Deborah J. , Manne-Goehler Jennifer , Seiglie Jacqueline A. 
Published: October 2022

<p> </p>
<p><strong>OBJECTIVE</strong>: Estimate diabetes-related mortality in Mexico in 2020 compared to 2017-2019, following onset of the COVID-19 pandemic. </p>
<p><strong>RESEARCH DESIGN AND METHODS</strong>: Retrospective, state-level study using national death registries from Mexican adults ≥20 years for the 2017-2020 period. Diabetes-related death was defined using ICD-10 codes which listed diabetes as the primary cause of death, excluding certificates with COVID-19 as the primary cause of death. Spatial and negative binomial regression models were used to characterize the geographic distribution and socio-demographic and epidemiologic correlates of diabetes-related excess mortality, estimated as increases in diabetes-related mortality in 2020 compared to average 2017-2019 rates. </p>
<p><strong>RESULTS:</strong> We identified 148,437 diabetes-related deaths in 2020 (177/100,000 inhabitants), compared with an average of 101,496 deaths in 2017-2019 (125/100,000 inhabitants). In-hospital diabetes-related deaths decreased by 17.8% in 2020 compared to 2017-2019, whereas out-of-hospital deaths increased by 89.4%. Most deaths were attributable to type 2 diabetes (130/100,000 inhabitants). Compared with 2018-2019, hyperglycemic hyperosmolar state and diabetic ketoacidosis were the two contributing causes with the highest increase in mortality (128% and 116% increase, respectively). Diabetes-related excess mortality clustered in southern Mexico and was highest in states with higher social lag, higher rates of COVID-19 hospitalization, and higher prevalence of HbA1c ≥7.5%.</p>
<p><strong>CONCLUSIONS</strong>: Diabetes-related deaths increased among Mexican adults by 41.6% in 2020 after the onset of the COVID-19 pandemic, occurred disproportionately out-of-hospital, and were largely attributable to type 2 diabetes and to hyperglycemic emergencies. Disruptions in diabetes care and strained hospital capacity may have contributed to diabetes-related excess mortality in Mexico during 2020. </p>