bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated workflow to investigate the fracture interference effect on shale well performance
Authors: Ibrahim Ahmed Farid 
Published: June 2022

AbstractHorizontal drilling and multistage hydraulic fracturing applied in shale formations over the past decade. The operators are trying even closer cluster spacing to increase the initial rate, but it is at the expense of higher operation costs and complexity. This study presents an integrated workflow to investigate the effect of cluster interference on well performance. Analytical rate transient analysis (RTA) was combined with reservoir numerical simulation to calculate the effective fracture surface area (ACe) for hydrocarbon production. A proxy model was built to estimate the effective to actual stimulated fracture area ratio as a function of completion and reservoir parameters. The integrated workflow was applied to actual field data for two shale gas wells. An economic study was conducted to investigate the optimum spacing based on the well profitability. The well with a higher stage number and tighter cluster spacing had high cluster interference with a low ACe/ACa ratio. The well will drain the production area near the wellbore faster with a high initial production rate but with high production declining rate. Increasing the cluster spacing, with the same injected proppant volume, showed an increase in the ACe/ACa ratio, and a decrease in cluster interference. A lower initial rate was observed with a low production declining rate. Economic study showed optimum spacing of 60 ft based on the formation properties, capital cost, and gas price. As the interest rate, gas prices, and increases or low capital costs, the optimum completion tends to be with the tighter spacing to accelerate the production.
Exploring chitosan-shelled nanobubbles to improve HER2 + immunotherapy via dendritic cell targeting
Authors: Argenziano Monica , Occhipinti Sergio , Scomparin Anna , Angelini Costanza , Novelli Francesco , Soster Marco , Giovarelli Mirella , Cavalli Roberta 
Published: June 2022

AbstractImmunotherapy is a valuable approach to cancer treatment as it is able to activate the immune system. However, the curative methods currently in clinical practice, including immune checkpoint inhibitors, present some limitations. Dendritic cell vaccination has been investigated as an immunotherapeutic strategy, and nanotechnology-based delivery systems have emerged as powerful tools for improving immunotherapy and vaccine development. A number of nanodelivery systems have therefore been proposed to promote cancer immunotherapy. This work aims to design a novel immunotherapy nanoplatform for the treatment of HER2 + breast cancer, and specially tailored chitosan-shelled nanobubbles (NBs) have been developed for the delivery of a DNA vaccine. The NBs have been functionalized with anti-CD1a antibodies to target dendritic cells (DCs). The NB formulations possess dimensions of approximately 300 nm and positive surface charge, and also show good physical stability up to 6 months under storage at 4 °C. In vitro characterization has confirmed that these NBs are capable of loading DNA with good encapsulation efficiency (82%). The antiCD1a-functionalized NBs are designed to target DCs, and demonstrated the ability to induce DC activation in both human and mouse cell models, and also elicited a specific immune response that was capable of slowing tumor growth in mice in vivo. These findings are the proof of concept that loading a tumor vaccine into DC-targeted chitosan nanobubbles may become an attractive nanotechnology approach for the future immunotherapeutic treatment of cancer.
Graphical abstract
Prenatal Maternal Smoke, DNA Methylation, and Multi-omics of Tissues and Child Health
Authors: Cosin-Tomas Marta , Cilleros-Portet Ariadna , Aguilar-Lacasaña Sofía , Fernandez-Jimenez Nora , Bustamante Mariona 
Published: June 2022

AbstractPurpose of ReviewMaternal tobacco smoking during pregnancy is of public health concern, and understanding the biological mechanisms can help to promote smoking cessation campaigns. This non-systematic review focuses on the effects of maternal smoking during pregnancy on offspring’s epigenome, consistent in chemical modifications of the genome that regulate gene expression.Recent FindingsRecent meta-analyses of epigenome-wide association studies have shown that maternal smoking during pregnancy is consistently associated with offspring’s DNA methylation changes, both in the placenta and blood. These studies indicate that effects on blood DNA methylation can persist for years, and that the longer the duration of the exposure and the higher the dose, the larger the effects. Hence, DNA methylation scores have been developed to estimate past exposure to maternal smoking during pregnancy as biomarkers.SummaryThere is robust evidence for DNA methylation alterations associated with maternal smoking during pregnancy; however, the role of sex, ethnicity, and genetic background needs further exploration. Moreover, there are no conclusive studies about exposure to low doses or during the preconception period. Similarly, studies on tissues other than the placenta and blood are scarce, and cell-type specificity within tissues needs further investigation. In addition, biological interpretation of DNA methylation findings requires multi-omics data, poorly available in epidemiological settings. Finally, although several mediation analyses link DNA methylation changes with health outcomes, they do not allow causal inference. For this, a combination of data from multiple study designs will be essential in the future to better address this topic.
Systematic Cross-Biospecimen Evaluation of DNA Extraction Kits for Long- and Short-Read Multi-Metagenomic Sequencing Studies
Authors: Rehner Jacqueline , Schmartz Georges Pierre , Groeger Laura , Dastbaz Jan , Ludwig Nicole , Hannig Matthias , Rupf Stefan , Seitz Berthold , Flockerzi Elias , Berger Tim , Reichert Matthias Christian , Krawczyk Marcin , Meese Eckart , Herr Christian , Bals Robert , Becker Sören L. , Keller Andreas , Müller Rolf 
Published: June 2022

Abstract
High-quality DNA extraction is a crucial step in metagenomic studies. Bias by different isolation kits impairs the comparison across datasets. A trending topic is, however, the analysis of multiple metagenomes from the same patients to draw a holistic picture of microbiota associated with diseases. We thus collected bile, stool, saliva, plaque, sputum, and conjunctival swab samples and performed DNA extraction with three commercial kits. For each combination of the specimen type and DNA extraction kit, 20-gigabase (Gb) metagenomic data were generated using short-read sequencing. While profiles of the specimen types showed close proximity to each other, we observed notable differences in the alpha diversity and composition of the microbiota depending on the DNA extraction kits. No kit outperformed all selected kits on every specimen. We reached consistently good results using the Qiagen QiAamp DNA Microbiome Kit. Depending on the specimen, our data indicate that over 10 Gb of sequencing data are required to achieve sufficient resolution, but DNA-based identification is superior to identification by mass spectrometry. Finally, long-read nanopore sequencing confirmed the results (correlation coefficient &gt; 0.98). Our results thus suggest using a strategy with only one kit for studies aiming for a direct comparison of multiple microbiotas from the same patients.
Between Belonging and Identity in Ancient Judaism: The Role of Emotion in the Production of Identity - Reviewed: Kinship, Law and Politics: An Anatomy of Belonging. By Joseph E. David. Cambridge: Cambridge University Press, 2020. Pp. 156. $110.00 (cloth); $88.00 (digital). ISBN: 9781108499682.
Authors: Mermelstein Ari 
Published: June 2022

AbstractThis essay considers the vexed relationship between belonging and identity. Belonging is not an objective or unreflective association but rather an emotional assertion of attachment. That emotional connection is an indispensable component of identity, which, as Joseph David argues inKinship, Law and Politics: An Anatomy of Belonging, is a relationship charged with meaning. Accordingly, the distinction betweenbelongingas a privately held sentiment and thepolitics of belongingoverlooks the fact that the emotions associated with belonging define group membership. Belonging is not a private matter but an emotional relationship that shapes social life, reinforces a group’s identity politics, and finds expression in a group’s practices. Analysis of two case studies from ancient Judaism—the writings of Philo of Alexandria and the sectarian Dead Sea Scrolls—demonstrates the emotional, social, and discursive dimensions of belonging and the role it plays in producing identity. Belonging is not a stable concept but is rather one that assumes different forms depending on the emotional orientation of the group and the particulars of identity politics. For Philo, belonging reflects a universalistic love for all humanity that helps shape an identity embracing Jewish practice and Greek virtue. By contrast, the Dead Sea sect’s antipathy toward all other Jews requires that a sense of belonging express not only love for fellow sectarians but also hate for all outsiders.
NEW APPROACH TO SEPARATE AND DATE SMALL SPORES AND POLLEN FROM LAKE SEDIMENTS IN SEMI-ARID CLIMATES
Authors: Steinhoff Christoph , Pickarski Nadine , Litt Thomas , Hajdas Irka , Welte Caroline , Wurst Peter , Kühne David , Dolf Andreas , Germer Maximilian , Kallmeyer Jens 
Published: June 2022

ABSTRACTThe dating of pollen grains is emerging as the method of choice for lacustrine climate archives that contain few datable macrofossils. Due to the need for high-purity pollen concentrates, new methods are constantly being developed to precisely separate pollen grains. Flow cytometry represents a promising alternative to conventional approaches, enabling the identification of pollen grains through fluorescence and rapid separation for radiocarbon analysis using accelerator mass spectrometry, which has so far been limited to sediments with a high proportion of conifer pollen. We present a revised method for processing large sediment samples, resulting in high-purity pollen and spore concentrates. Using this approach small- to medium-sized pollen and bryophyte spores were isolated from Lake Van sediment samples (Eastern Anatolia, Turkey) in sufficient purity for radiocarbon dating. However, a systematic age discrepancy between pollen and bryophyte spore concentrates was noted. By adapting the chemical and cytometric methods, pure pollen concentrates can be created for sediments with low organic content enabling age determination of climate archives with a low proportion of large pollen or low pollen concentration.
TESTING THE METHODS FOR DETERMINATION OF RADIOCARBON CONTENT IN LIQUID FUELS IN THE GLIWICE RADIOCARBON AND MASS SPECTROMETRY LABORATORY
Authors: Baranyika Jean Baptiste , Piotrowska Natalia , Kłusek Marzena , Michczyński Adam , Pawlyta Jacek 
Published: June 2022

ABSTRACTDetermining the biocomponents in liquid fuels using radiocarbon radioisotope (14C) dating requires sample preparation adaptations to the conditions of the Gliwice Radiocarbon and Mass Spectrometry Laboratory. Liquid scintillation counting (LSC), and accelerator mass spectrometry (AMS) were investigated using six samples, including one 14C-free fuel and modern hydrotreated vegetable oil (HVO). For AMS, samples were prepared using tin capsules for liquids for EA combustion and graphitization in an AGE system. For LSC, liquid fuels were prepared by mixing with purified preheated sand and a benzene synthesis line. Benzene resublimation was also tested. IRMS measurements were also conducted for benzene to account for isotopic fractionation. Sample background measurements using both methods showed good performances by both AMS and LSC without resublimation. Comparable results were also obtained for HVO.
Can Grid Governance Fix the Party-state's Broken Windows? A Study of Stability Maintenance in Grassroots China
Authors: Xu Jianhua , He Siying 
Published: June 2022

AbstractGrid governance has been developed by the Chinese party-state to collect intelligence at the grassroots level for the early pre-emption of what it defines as social instability. Using data collected from four months’ participant observation and extensive interviews with personnel who work in the grid governance system in what we call W Street, a location in a second-tier city in southern China, this paper examines how China's grid governance is used for stability maintenance and how in practice the system has become alienated from its original purpose of social control. We find that grid governance is achieved mainly through three mechanisms: intelligence gathering, case coordination and real-time reporting for stability maintenance. We further reveal that while grid governance provides an important infrastructural power for intelligence gathering, the realization of this power could be hindered by contradictory logics among different levels of government. This research not only provides empirical data on how China's grid governance works in practice but also calls for a rethinking of the capacity of China's stability maintenance regime.
Forecasting Eruptions at Poorly Known Volcanoes Using Analogs and Multivariate Renewal Processes
Authors: Wang Ting , Bebbington Mark , Cronin Shane , Carman Joel 
Published: June 2022

AbstractForecasting future destructive eruptions from re‐awakening volcanoes remains a challenge, mainly due to a lack of previous event data. This sparks a search for similar volcanoes to provide additional information, especially those with better compiled and understood event records. However, we show that some of the most obviously geologically comparable volcanoes have differing statistical occurrence patterns. Using such matches produces large forecasting uncertainties. We created a statistical tool to identify and test the compatibility of potential analogue volcanoes based on repose‐time characteristics from world‐wide datasets. Selecting analogue volcanoes with compatible behavior for factors being forecast, such as repose time, significantly reduces forecasting uncertainties. Applying this tool to Tongariro volcano (NZ), there is a 5% probability for a Volcanic Explosivity Index (VEI) ≥ 3 explosive eruption in the next 50 years. Using pre‐historic geological records of a smaller available set of analogs, we forecast a 1% probability of a VEI ≥ 4 eruption in the next 50 years.
Plate‐Rate Frictional Behavior of Sediment Inputs to the Hikurangi Subduction Margin: How Does Lithology Control Slow Slip Events?
Authors: Eijsink A. M. , Ikari M. J. 
Published: June 2022

AbstractThe northern Hikurangi subduction margin hosts slow slip events (SSEs), which are exceptionally shallow (<15 km). The sedimentary sequence on the incoming plate is therefore representative of the shallow fault material where the SSEs will take place once they enter the subduction zone. Knowledge about the frictional behavior of these sediments is required to know which lithologies are capable of hosting SSEs, and what mechanisms are causing them. Frictional behavior is material specific and depends on sliding velocity, but it is unknown how these natural sediments behave at plate‐rate velocities. We performed laboratory shearing experiments testing the major lithologies sampled during International Ocean Discovery Program (IODP) Expedition 375, at velocities ranging from the plate convergence rate at the Hikurangi margin (5 cm/year), up to those characteristics of the shallow SSEs (160 and 530 cm/year), under simulated in‐situ as well as standardized conditions. We find that the calcite‐rich pelagic sediments are relatively strong and display the velocity‐weakening frictional behavior required for slip events, whereas other lithologies are weaker and show velocity‐neutral to velocity‐strengthening friction. We observe spontaneous laboratory SSEs in the calcareous pelagic sediments, which show partial locking in between sliding events, consistent with the interpretation of SSEs within the spectrum of slow to fast earthquakes. For the Hikurangi margin, our results suggest that SSE occurrence requires the stronger carbonate‐rich unit to be incorporated into the plate‐boundary fault zone, which we suggest occurs because the rough incoming plate introduces geometrical complexity into the fault zone.
Deep Outer‐Rise Faults in the Southern Mariana Subduction Zone Indicated by a Machine‐Learning‐Based High‐Resolution Earthquake Catalog
Authors: Chen Han , Yang Hongfeng , Zhu Gaohua , Xu Min , Lin Jian , You Qingyu 
Published: June 2022

AbstractOuter‐rise faults are predominantly concentrated near ocean trenches due to subducted plate bending. These faults play crucial roles in the hydration of subducted plates and the consequent subducting processes. However, it has not yet been possible to develop high‐resolution structures of outer‐rise faults due to the lack of near‐field observations. In this study we deployed an ocean bottom seismometer (OBS) network near the Challenger Deep in the Southernmost Mariana Trench, between December 2016 and June 2017, covering both the overriding and subducting plates. We applied a machine‐learning phase detector (EQTransformer) to the OBS data and found more than 1,975 earthquakes. An identified outer‐rise event cluster revealed an outer‐rise fault penetrating to depths of 50 km, which was inferred as a normal fault based on the extensional depth from tomographic images in the region, shedding new lights on water input at the southmost Mariana subduction zone.
The Role of Atmospheric Blocking in Regulating Arctic Warming
Authors: You Cheng , Tjernström Michael , Devasthale Abhay , Steinfeld Daniel 
Published: June 2022

AbstractUsing ERA5 reanalysis we find positive trends in poleward transport of moisture and heat during 1979–2018 over the winter Barents Sea sector and summer East Siberian Sea sector. The increase in blocking occurrence (blocking days) can explain these trends. Blocking occurrence over the Barents Sea sector significantly increased in the last 40 winters, inducing increasingly stronger poleward transport of moisture and heat. The high linear correlation between poleward energy transports and temperature over the Barents Sea sector suggests that poleward energy transports dominate the regional warming trend there. Meanwhile, in summer, more frequently occurring blocking over the Beaufort Sea sector causes a positive trend of poleward moist and heat transport over the East Siberian Sea sector. The high linear correlation between the blocking occurrence and temperature suggests that the increasing shortwave radiation and subsidence within the more frequently occurring blocking contribute to the regional warming trend.
The Deuterium Isotopic Ratio of Water Released From the Martian Caps as Measured With TGO/NOMAD
Authors: Villanueva Geronimo L. , Liuzzi Giuliano , Aoki Shohei , Stone Shane W. , Brines Adrian , Thomas Ian R. , Lopez‐Valverde Miguel Angel , Trompet Loic , Erwin Justin , Daerden Frank , Ristic Bojan , Smith Michael D. , Mumma Michael J. , Faggi Sara , Kofman Vincent , Robert Séverine , Neary Lori , Patel Manish , Bellucci Giancarlo , Lopez‐Moreno Jose Juan , Vandaele Ann Carine 
Published: June 2022

AbstractWe report vertical profiles of water and D/H for one Martian year as measured with the TGO/NOMAD instrument. The observations were performed via solar occultation, providing water profiles up to ∼100 km and D/H up to ∼60 km, with a vertical resolution of 1–2 km. The measurements reveal dramatic variability of water and D/H over short timescales and with altitude and location on the planet. We investigated the release of seasonal water from the polar caps during southern and northern summer, by mapping water and its D/H near the polar regions. Above the hygropause, the D/H drops substantially below 2 VSMOW, and both seasonal polar caps show a consistent and enriched D/H of 5–7 VSMOW within the hygrosphere.
Simultaneous Measurements of Elastic Wave Velocity and Porosity of Epidosites Collected From the Oman Ophiolite: Implication for Low VP/VS Anomaly in the Oceanic Crust
Authors: Nagase Kumpei , Hatakeyama Kohei , Okazaki Keishi , Akamatsu Yuya , Abe Natsue , Michibayashi Katsuyoshi , Katayama Ikuo 
Published: June 2022

AbstractGeophysical surveys of the oceanic crust indicate that hydrothermal circulation universally occurs in seismic layer 2, which results in a low seismic velocity and high VP/VS due to the occurrence of cracks. However, the anomalously low VP/VS observed at the layer 2/3 transition cannot be explained by the crack model, because the effective medium theory predicts an increase in VP/VS due to crack development. In this study, we present the first evidence that shows the low VP/VS in the oceanic crust is caused by epidotization due to upward fluid flow in hydrothermal systems. Simultaneous measurements of elastic wave velocity and porosity of epidosites collected by the Oman Drilling Project show that quartz precipitation and spheroidal pores results in low VP/VS, in contrast to diabases that contain thin cracks. The presence of spheroidal pores in epidosites is supported by CT imaging, and is consistent with predictions from the effective medium model.
Marsh Sedimentation Controls Delta Top Morphology, Slope, and Mass Balance
Authors: Sanks K. M. , Zapp S. M. , Silvestre J. R. , Shaw J. B. , Dutt R. , Straub K. M. 
Published: June 2022

AbstractRising sea levels, subsidence, and decreased fluvial sediment load threaten river deltas and their wetlands. However, the feedbacks between fluvial and non‐fluvial (marsh) deposition remain weakly constrained. We investigate how non‐riverine, elevation‐controlled deposition typified by marshes impacts sediment partitioning between a delta's topset, coastal zone, and foreset by comparing a delta experiment with proxy marsh accumulation to a control. Marsh accumulation alters fluvial sediment distribution by decreasing the slope in the marsh window by ∼50%, creating a 78% larger marsh zone. Fluvial incursions into the marsh window trap 1.3 times more clastic volume. The volume exported to deep water remains unchanged. Marsh deposition shifts elevation distributions toward sea level, which produces a hypsometry akin to field‐scale deltas. The elevation‐lowering effect of marshes on an equilibrium delta shown here constitutes an unexplored feedback and an important aspect of coastal sustainability.
Record Low Antarctic Sea Ice Cover in February 2022
Authors: Turner John , Holmes Caroline , Caton Harrison Thomas , Phillips Tony , Jena Babula , Reeves‐Francois Tylei , Fogt Ryan , Thomas Elizabeth R. , Bajish C. C. 
Published: June 2022

AbstractOn 25 February 2022 Antarctic sea ice extent dropped to a satellite‐era record low level of 1.92 × 106 km2, 0.92 × 106 km2 below the long‐term mean. The area of sea ice was also at a record low level of 1.24 × 106 km2. Although no individual sector was at a record low, at the minimum there were negative sea ice anomalies in all sectors of the Southern Ocean, with the largest in the Ross (contributing 46%) and Weddell Seas (26%). The Amundsen Sea Low had a record low depth in October/November 2021, with a series of very deep depressions giving strong offshore winds. These accelerated ice loss during the melt season, creating a 1.00 × 106 km2 coastal polynya in the Ross Sea. In the northern Weddell Sea, westerly winds of record strength led to ice export from the region.