bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient data transmission using trusted third party in smart home environments
Authors: Panda Niharika , Supriya M. 
Published: December 2022

AbstractCurrently, deployed Internet of Things (IoT) technology acts as a passive observer of the environment that sends data to a remote location. Developing and deploying future IoT applications will need re-tasking this one-way behaviour in a reliable manner. A novel computationally tractable optimization technique that can accept cross-layer resource configurations and focus on network enhancement with longevity should be created for the smart home, one of the heterogeneous IoT applications. This study shows different smart home architectures in static and mobile environments, taking into account some of the challenges like orchestration, mobility, and range in IoT. For network communication, routing protocol over 6LoWPAN (RPL) is used. The goal of the work is to optimize the communication network in both static and mobile environment. To attain the goal, this paper proposes an algorithm that improves the path selection by modifying the existing objective functions of RPL. The proposed smart home architectures are analysed and compared based on different parameters such as packet reception ratio, network overhead, throughput, average latency, and total energy consumption. Even when some of the devices in the smart home are mobile, the modified smart home-optimized path (MSHOP) is found to achieve a packet reception ratio of 99.93%, minimum latency of 0.9 s, and the highest total energy usage in the network of 3373 millijoules. In conclusion, proposed MSHOP outperforms all existing smart home architectures when considering network efficiency, time, and usability.
Relationship between polygenic risk scores and symptom dimensions of schizophrenia and schizotypy in multiplex families with schizophrenia
Authors: Ahangari Mohammad , Bustamante Daniel , Kirkpatrick Robert , Nguyen Tan-Hoang , Verrelli Brian C. , Fanous Ayman , Kendler Kenneth S. , Webb Bradley T. , Bacanu Silviu-Alin , Riley Brien P. 
Published: December 2022

BackgroundPsychotic disorders and schizotypal traits aggregate in the relatives of probands with schizophrenia. It is currently unclear how variability in symptom dimensions in schizophrenia probands and their relatives is associated with polygenic liability to psychiatric disorders.AimsTo investigate whether polygenic risk scores (PRSs) can predict symptom dimensions in members of multiplex families with schizophrenia.MethodThe largest genome-wide data-sets for schizophrenia, bipolar disorder and major depressive disorder were used to construct PRSs in 861 participants from the Irish Study of High-Density Multiplex Schizophrenia Families. Symptom dimensions were derived using the Operational Criteria Checklist for Psychotic Disorders in participants with a history of a psychotic episode, and the Structured Interview for Schizotypy in participants without a history of a psychotic episode. Mixed-effects linear regression models were used to assess the relationship between PRS and symptom dimensions across the psychosis spectrum.ResultsSchizophrenia PRS is significantly associated with the negative/disorganised symptom dimension in participants with a history of a psychotic episode (P = 2.31 × 10−4) and negative dimension in participants without a history of a psychotic episode (P = 1.42 × 10−3). Bipolar disorder PRS is significantly associated with the manic symptom dimension in participants with a history of a psychotic episode (P = 3.70 × 10−4). No association with major depressive disorder PRS was observed.ConclusionsPolygenic liability to schizophrenia is associated with higher negative/disorganised symptoms in participants with a history of a psychotic episode and negative symptoms in participants without a history of a psychotic episode in multiplex families with schizophrenia. These results provide genetic evidence in support of the spectrum model of schizophrenia, and support the view that negative and disorganised symptoms may have greater genetic basis than positive symptoms, making them better indices of familial liability to schizophrenia.
Maf family transcription factors are required for nutrient uptake in the mouse neonatal gut
Authors: Bara Anne M. , Chen Lei , Ma Celina , Underwood Julie , Moreci Rebecca S. , Sumigray Kaelyn , Sun Tongyu , Diao Yarui , Verzi Michael , Lechler Terry 
Published: December 2022

ABSTRACT
There are fundamental differences in how neonatal and adult intestines absorb nutrients. In adults, macromolecules are broken down into simpler molecular components in the lumen of the small intestine, then absorbed. In contrast, neonates are thought to rely on internalization of whole macromolecules and subsequent degradation in the lysosome. Here, we identify the Maf family transcription factors MAFB and c-MAF as markers of terminally differentiated intestinal enterocytes throughout life. The expression of these factors is regulated by HNF4α and HNF4γ, master regulators of enterocyte cell fate. Loss of Maf factors results in a neonatal-specific failure to thrive and loss of macromolecular nutrient uptake. RNA-Seq and CUT&RUN analyses defined an endo-lysosomal program as being downstream of these transcription factors. We demonstrate major transcriptional changes in metabolic pathways, including fatty acid oxidation and increases in peroxisome number, in response to loss of Maf proteins. Finally, we show that loss of BLIMP1, a repressor of adult enterocyte genes, shows highly overlapping changes in gene expression and similar defects in macromolecular uptake. This work defines transcriptional regulators that are necessary for nutrient uptake in neonatal enterocytes.
CureSCi Metadata Catalog–Making sickle cell studies findable
Authors: Pan Huaqin , Ives Cataia , Mandal Meisha , Qin Ying , Hendershot Tabitha , Popovic Jen , Brambilla Donald , Stratford Jeran , Treadwell Marsha , Wu Xin , Kroner Barbara 
Published: December 2022

Objectives
To adopt the FAIR principles (Findable, Accessible, Interoperable, Reusable) to enhance data sharing, the Cure Sickle Cell Initiative (CureSCi) MetaData Catalog (MDC) was developed to make Sickle Cell Disease (SCD) study datasets more Findable by curating study metadata and making them available through an open-access web portal.

Methods
Study metadata, including study protocol, data collection forms, and data dictionaries, describe information about study patient-level data. We curated key metadata of 16 SCD studies in a three-tiered conceptual framework of category, subcategory, and data element using ontologies and controlled vocabularies to organize the study variables. We developed the CureSCi MDC by indexing study metadata to enable effective browse and search capabilities at three levels: study, Patient-Reported Outcome (PRO) Measures, and data element levels.

Results
The CureSCi MDC offers several browse and search tools to discover studies by study level, PRO Measures, and data elements. The “Browse Studies,” “Browse Studies by PRO Measures,” and “Browse Studies by Data Elements” tools allow users to identify studies through pre-defined conceptual categories. “Search by Keyword” and “Search Data Element by Concept Category” can be used separately or in combination to provide more granularity to refine the search results. This resource helps investigators find information about specific data elements across studies using public browsing/search tools, before going through data request procedures to access controlled datasets. The MDC makes SCD studies more Findable through browsing/searching study information, PRO Measures, and data elements, aiding in the reuse of existing SCD data.
Anthrax outbreak investigation in Tengwe, Mashonaland West Province, Zimbabwe, 2022
Authors: Hamutyinei Dhliwayo Theresa , Chonzi Prosper , Madembo Collen , Juru Tsitsi Patience , Chadambuka Addmore , Gombe Notion Tafara , Chikerema Silvester , Shambira Gerald , Umeokonkwo Chukwuma David , Tshimanga Mufuta 
Published: December 2022

Background
Anthrax continues to be a disease of public health concern in Zimbabwe. Between December 2021 and February 2022, Tengwe reported 36 cases of human anthrax. Gastrointestinal anthrax has the potential to cause serious outbreaks leading to loss of human life. We investigated the outbreak, identified the risk factors using one health approach to inform outbreak control.

Materials and methods
We conducted descriptive analysis of the outbreak and a 1:2 unmatched case control study to identify risk factors for anthrax. A case was any Tengwe resident who developed an ulcer and/or abdominal symptoms and epidemiologically linked to a confirmed environmental exposure. Validated, structured interviewer-administered questionnaires were used to collect data from the cases and neighbourhood controls. Soil and dried meat samples were collected for laboratory investigations. District preparedness and response was assessed using a checklist. Data was analysed using Epi Info version 7.2.5. The odds of exposure were calculated for each risk factor examined. Multivariable logistic regression analysis was performed to identify the independent factors associated with contracting anthrax.

Results
Through active case finding we identified 36 cases, 31 were interviewed. Twenty-one (67.7%) were males. The median age was 33 years (Inter quartile range: 22–54). Nineteen (61.2%) cases presented with abdominal symptoms with zero deaths reported. The independent risk factor for contracting anthrax was eating under-cooked meat (aOR = 12.2, 95% CI: 1.41–105.74, p = 0.023). All samples collected tested positive for anthrax. No livestock vaccinations or zoonotic meetings were being conducted prior to the outbreak. Notification of the outbreak was done 11 days after index case presentation however one health response was instituted within 24 hours.

Conclusion
The anthrax was confirmed in Tengwe. Consumption of under-cooked meat was associated with gastrointestinal anthrax. The timely one health response resulted in excellent outcomes. Using one health approach in managing zoonotic threats is encouraged.
Will the EU Taxonomy Impact the Trade Specialisation of European Economies?
Authors: Köppl-Turyna Monika , Schwarzbauer Wolfgang 
Published: December 2022

Abstract
The introduction of the taxonomy will alter trade patterns and trade specialisation, in spite of the signs that EU members are specialised in industries and economic activities that are favoured by its introduction. The taxonomy is likely to further work not only directly but also through supply chains, as obtaining more attractive funding for companies is indirectly linked to the compliance of the company’s suppliers as well. However, managing the transition to green production will require further policy measures at the regional, national, and international levels. Given that several policy measures and initiatives are already in place, doubts can be raised as to whether the green transition can be achieved efficiently by the introduction of the taxonomy.
Cerebral palsy – brain repair with stem cells
Authors: Jensen Arne 
Published: December 2022

Abstract
Cerebral palsy, the most common disability in childhood, is a devastating non-progressive ailment of the infants’ brain with lifelong sequelae, e.g., spastic paresis, chronic pain, inability to walk, intellectual disability, behavioral disorders, for which there is no cure at present. CP may develop after pediatric brain damage caused, e.g., by hypoxic-ischemia, periventricular leukomalacia, intracranial hemorrhage, hypoxic-ischemic encephalopathy, trauma, stroke, and infection. About 17 million people worldwide live with cerebral palsy as a result of pediatric brain damage. This reflects both the magnitude of the personal, medical, and socioeconomic global burden of this brain disorder and the overt unmet therapeutic needs of the pediatric population. This review will focus on recent preclinical, clinical, and regulatory developments in cell therapy for infantile cerebral palsy by transplantation of cord blood derived mononuclear cells from bench to bedside. The body of evidence suggests that cord blood cell therapy of cerebral palsy in the autologous setting is feasible, effective, and safe, however, adequately powered phase 3 trials are overdue.
Predictive value of highly sensitive basal versus stimulated thyroglobulin measurement in long-term follow-up of thyroid cancer
Authors: Pabst Kim Magaly , Seifert Robert , Hirmas Nader , Broecker-Preuss Martina , Weber Manuel , Peter Fendler Wolfgang , Bartel Timo , Theurer Sarah , Herrmann Ken , Görges Rainer 
Published: December 2022

Objective
Recurrence of differentiated thyroid cancer (DTC) is associated with reduced quality of life, and therefore, early identification of patients at risk is urgently needed.Here we investigated the predictive power of various cut-off values of single stimulated thyroglobulin (s-Tg) and single highly sensitive measured, unstimulated thyroglobulin (u-hsTg) measurements close to the end of primary therapy for recurrence-free survival (RFS) in long-term follow-up (>10 years) of patients with DTC.

Methods
In DTC patients with adjuvant radioiodine therapy, we assessed retrospectively u-hsTg (6 ± 3 months before s-Tg measurement) and s-Tg measurements (≤24 months after last radioiodine therapy). Positive predictive (PPV)/negative predictive values (NPV) of various cut-off values (s-Tg: 0.5/1.0 ng/mL; u-hsTg: 0.09/0.2 ng/mL) for patient outcomes as well as additional factors associated with disease development were analyzed.

Results
In total, 175 patients were retrospectively reviewed (tumor recurrence: n = 14/complete remission: n = 161). Examined cut-off values for s-Tg and u-hsTg showed significant predictive power for RFS (log-rank: all P < 0.001). NPV/PPV for s-Tg were 98.6%/36.4%, respectively (0.5 ng/mL cut-off) and 96.7%/42.9%, respectively (1.0 ng/mL cut-off); those for u-hsTg were 97.3%/35.7%, respectively (0.09 ng/mL cut-off) and 95.2%/85.7%, respectively (0.2 ng/mL cut-off). U-hsTg (P < 0.001) and patient age (P < 0.05) were significantly associated with tumor recurrence. One-third of patients with tumor recurrence in the course initially showed undetectable u-hsTg after completion of primary therapy.

Conclusion
With >10 years of follow-up, both s-Tg and u-hsTg have a comparably high predictive power for RFS, while only u-hsTg was significantly associated with a recurrence event.Serial u-hsTg measurements seem warranted since patients with tumor recurrence during follow-up may have an undetectable tumor marker at baseline.
Use of Tranexamic Acid to Reduce PostOperative Bleeding in Orthopaedic Oncology
Authors: Andreani Lorenzo , Del Chiaro Andrea , Ipponi Edoardo , Di Sacco Federico , Caterino Martina , Capanna Rodolfo 
Published: December 2022

Background: Orthopaedic oncology often causes major blood losses that may put at risk patients’ hemodynamic balance and their overall clinical stability. To this date, transfusion therapy still represents the pivotal treatment to counterbalance the reduction in hemoglobin levels which occur after surgery. Although effective, transfusions are expensive and inevitably associated with a number of complications and therefore other solutions, such as procoagulative drugs, could play an important role to prevent massive blood losses.Material and methods: We reviewed the clinical intercourse of 37 patients who underwent major bone resection due to malignant tumors of the lower limb. Cases were divided in two different groups: group G1 consisting of 12 patients treated intraoperatively with tranexamic acid and group G2 which was made of 25 controls.Results: On average, patients treated with tranexamic acid (G1) required transfusion of 3.9 concentrated blood cells units during surgery and 0.9 units during the postoperative course. Other patients (G2), for their part, required on average 3.1 units intraoperatively and 2.1 units postoperatively. No significant difference was found in intraoperative transfusion rate (p=0.402). Instead, postoperative transfusions were significantly less frequent for patients treated with tranexamic acid (p=0.023). None of the 12 patients treated with tranexamic acid had evidence of Deep Vein Thrombosis.Conclusion: Our outcomes indicate that the use of TXA was effective in reducing blood losses also for major surgical interventions in orthopedic oncology.
EARLY PREDICTORS OF SEVERE DISABILITY IN GUILLAIN–BARRÉ SYNDROME
Authors: GÖRGÜLÜ Ümit , GEÇER Burak , BİLEN Şule , KOLCU Giray 
Published: December 2022

Objective
Guillain-Barré syndrome (GBS) is an autoimmune
neurological disorder with non-negligible morbidity
and mortality. This study aimed to evaluate different
patient characteristics and laboratory findings as early
predictors of severe disability in GBS patients.
Material and Method
We retrospectively reviewed the medical records of
121 patients diagnosed with GBS between January
1, 2018, and December 31, 2021. Data regarding
demographic characteristics, presenting complaints,
co-morbidities, previous infection history, neurological
examination findings, GBS Disability Scores (GDS)
on the 1st day and by the end of the first month,
laboratory parameters of serological and cerebrospinal
fluid (CSF) examination, electromyoneurography
results, GBS subtypes, treatments, treatment-related
complications, and prognoses were recorded.
Results
The median age of the 121 patients was 58 (20–87)
years (n = 73 males, 60%). The average GDS was
3 on admission and 2 at the end of the first month.
The serum C-reactive protein (CRP) and CSF protein
levels were raised, while vitamin D levels were
reduced. Advanced age, cranial nerve involvement,
history of infection, admission to the intensive care
unit (ICU), need for mechanical ventilation (MV),
presence of complications, high plasma CRP levels,
neutrophil-lymphocyte ratio (NLR), and plateletlymphocyte
ratio (PLO) were significantly associated
with severe disability in GBS patients at day 1 and at
the end of the first month.
Conclusion
We identified multiple characteristics that can predict
severe disability in GBS patients.
Is there a relationship between COVID-19 and sarcoidosis? A case report
Authors: Yasar Kucukardali , Arzu Gunturk , Mehmet Akif Ozturk , Şenay Acikel , Hatice Zeynep Ceylan , Pınar Fırat , Banu Salepci 
Published: December 2022

Mediastinal lymphadenopathy is rare in Coronavirus Disease-2019 (COVID-19) patients with mild clinical course. The frequency of lymphadenopathy increases in COVID-19 patients who develop Acute Respiratory Distress Syndrome (ARDS). In a 38-year-old male patient, mediastinal lymphadenopathy and asymptomatic pulmonary embolism were detected during the third week of COVID-19 infection at home. Sarcoidosis was diagnosed with a finding of non-caseating granulomas. Even if it is asymptomatic, pulmonary embolism should be considered, especially in COVID-19 patients with high C - Reactive Protein (CRP) and D-dimer levels. If mediastinal lymphadenopathy is detected in mild COVID-19 cases, systemic diseases should be investigated. In severe COVID-19 cases, if lymphadenopathy continues despite a COVID-19 recovery, further investigation is required.
The Influence of Feeling Lonely and Received Social Support on Medication Adherence in Elderly with Hypertension
Authors: Dwi Novita Sari  , Wahyu Utami  , Elida Zairina  
Published: December 2022

Background: Hypertension is currently a non-contagious disease that primarily affects the elderly population in Indonesia. Medication adherence is critical in managing hypertension and reducing the risk of morbidity and mortality. Previous research has found that loneliness and support received by older adults with hypertension influence medication adherence. Objective: This study aimed to examine the impact of feeling lonely and receiving social support on medication adherence in the elderly with hypertension at the Community Health Center in Surabaya. Methods: The study design of this research was a descriptive cross-sectional study from December 2021 to March 2022. A total of 235 eligible subjects fulfilled the inclusion criteria. The instruments used in the data collection were the patient's information form, UCLA-Loneliness Scale, MOS-Social Support Survey, and the ARMS (Adherence to Refill and Medication Scale). Results: The results revealed that the correlation between loneliness and social support was significantly associated with medication adherence in the elderly with hypertension (p < 0.05). In addition, other factors, such as occupation status, living status, comorbidity, the number of drugs taken, and antihypertensive drug therapy, showed a significant correlation with medication adherence (p < 0,05). The most influential factor on medication adherence was loneliness (35.5%), followed by social support (24.4%), the number of drugs taken (7.1%), antihypertensive drug therapy (monotherapy or combination therapy (2.5%), occupation status (2.4%), comorbidity (1.6%), and living status (0.2%). Conclusion: This study confirms that feeling lonely and receiving social support affect medication adherence in the elderly with hypertension at the Community Health Center in Surabaya.
The Effect of Gracilaria verrucosa Seaweed Flour Proportion with White Glutinous Rice Flour (Oryza sativa Glutinosa) and CMC (Carboxy Methyl Cellulose) Concentration on Physical and Chemical Characteristics of Seaweed Dodol
Authors: Elfahira Dieo Riezma , Hudi Lukman , Nurbaya Syarifa Ramadhani 
Published: December 2022

Gracillaria verrucosa seaweed is one type of agar-producing red algae (agarophyte) that has the potential to be developed because it can be cultivated in polyculture in ponds together with shrimp and crab rearing. Gracillaria verrucosa seaweed is usually used as a raw material for making gelatin, but it would be better to develop it in its processing so that it can produce products that have better economic value and nutritional value by utilizing Gracillaria verrucosa seaweed, and one of these preparations is dodol. This study used factorial RAK (Randomized Block Design) which was repeated 3 times, with the first factor being the proportion of Gracilaria verrucosa seaweed flour with white glutinous rice flour (P) 75%: 25%, 50%: 50%, and 25%: 75%. The second factor is the concentration of CMC (K) 2%, 4%, and 6%. The data were analyzed using analysis of variance and then continued with the BNJ test (Honest Significant Difference) at 5% level. The best treatment was obtained in the P3K3 treatment (the proportion of Gracilaria verrucosa seaweed flour with white glutinous rice flour 75%: 25% and CMC concentration 6%) with color profile L (lightness) 43.1; color profile *a (redness) 4.9; color profile *b (yellowness) 10.6; 1.66N texture water content 37.40%; free fatty acid content of 0.28%; reducing sugar content 0.4%; antioxidant activity 368.6 g/ml.