bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial Intelligence-Based CT Imaging on Diagnosis of Patients with Lumbar Disc Herniation by Scalpel Treatment
Authors: Fan Xiaofei , Qiao Xiaoming , Wang Zhisheng , Jiang Luetao , Liu Yue , Sun Qingshan 
Published: May 2022

The aim of this study was to explore the application effect of computed tomography (CT) image based on active contour segmentation algorithm in the treatment of lumbar disc herniation (LDH) with scalpel. 78 patients with LDH were selected and divided into a lateral crypt block treatment group (group A) and a scalpel treatment group (group B) randomly. All the patients were examined by lumbar CT images based on artificial intelligence (AI) algorithm. Then, the clinical efficacy and Japanese orthopedic association (JOA) and visual analogue scale (VAS) scores were compared between the two groups. It was found that the total effective rate in group B was higher (92.31% vs. 84.62%) (

P

< 0.05). After treatment, the disc height (DH) in group A was obviously lower, and the vertebral body slippage was obviously higher (

P

< 0.05) than before. After treatment, there were more patients with nerve root location changes, edema, or disappearance in group B (

P

< 0.05). In contrast with JOA and VAS scores before treatment, both the groups showed obvious differences after treatment, especially group B (

P

< 0.05). Therefore, the CT images based on the AI algorithm can be used to analyze the treatment effect of LDH, and the scalpel treatment was more effective.
Phytochemical, Antioxidant, Anti-Inflammatory, and Thrombolytic Properties of Cleisomeria lanatum (Lindl.) Lindl. ex G. Don
Authors: Rahman Minhajur , Surag Abu Taleb , Begum Roxy , Hossain Tusher Md. Shakhuat , Huda Mohammed Kamrul 
Published: May 2022

For the first time, Cleisomeria lanatum (family: Orchidaceae) has been investigated for its phytochemical, antioxidant, anti-inflammatory, and thrombolytic properties. All phytochemicals studied were identified in varying degrees during qualitative screening. In quantitative screening, a maximum of 106.02 ± 0.08 mg/g alkaloids (root), 179.67 ± 8.83 mg/g phenols (stem), 17.34 ± 0.88 mg/g flavonoids (stem), 73.67 ± 1.76 mg/g tannins (stem), and 180.04 ± 0.02 μg/mL proteins (root) were detected. Antioxidant, anti-inflammatory, and thrombolytic properties were investigated using a free-radical scavenging assay, heat-induced albumin denaturation assay, and blood clotting inhibition assay. The root extracts had the most effective antioxidant (IC50 = 67.98 μg/mL) and anti-inflammatory (IC50 = 60.86 μg/mL) properties, whereas the stem extracts had the most effective thrombolytic property (IC50 = 163.8 μg/mL). The bioactivities studied also had a significant positive relationship (r = 0.9;

p

<

0.05

) with the amount of phenolics and tannins.
Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion and Resistance to Immune-Checkpoint Blockade
Authors: Wang Wei , Lozar Taja , Golfinos Athena E. , Lee Denis , Gronski Ellery , Ward-Shaw Ella , Hayes Mitchell , Bruce Justine Y. , Kimple Randall J. , Hu Rong , Harari Paul M. , Xu Jin , Keske Aysenur , Sondel Paul M. , Fitzpatrick Megan B. , Dinh Huy Q. , Lambert Paul F. 
Published: May 2022

AbstractPurpose:We investigated whether in human head and neck squamous cell carcinoma (HNSCC) high levels of expression of stress keratin 17 (K17) are associated with poor survival and resistance to immunotherapy.Experimental Design:We investigated the role of K17 in regulating both the tumor microenvironment and immune responsiveness of HNSCC using a syngeneic mouse HNSCC model, MOC2. MOC2 gives rise to immunologically cold tumors that are resistant to immune-checkpoint blockade (ICB). We engineered multiple, independent K17 knockout (KO) MOC2 cell lines and monitored their growth and response to ICB. We also measured K17 expression in human HNSCC of patients undergoing ICB.Results:MOC2 tumors were found to express K17 at high levels. When knocked out for K17 (K17KO MOC2), these cells formed tumors that grew slowly or spontaneously regressed and had a high CD8+ T-cell infiltrate in immunocompetent syngeneic C57BL/6 mice compared with parental MOC2 tumors. This phenotype was reversed when we depleted mice for T cells. Whereas parental MOC2 tumors were resistant to ICB treatment, K17KO MOC2 tumors that did not spontaneously regress were eliminated upon ICB treatment. In a cohort of patients with HNSCC receiving pembrolizumab, high K17 expression correlated with poor response. Single-cell RNA-sequencing analysis revealed broad differences in the immune landscape of K17KO MOC2 tumors compared with parental MOC2 tumors, including differences in multiple lymphoid and myeloid cell types.Conclusions:We demonstrate that K17 expression in HNSCC contributes to immune evasion and resistance to ICB treatment by broadly altering immune landscapes of tumors.
Occurrence patterns of herpetofauna in different habitat types of western Terai Arc Landscape, India
Authors: Gajendra Singh Mehra  , Mohanty Nakulananda , Dutta Sushil Kumar 
Published: May 2022

The Terai Arc Landscape (TAL) is an important region of biodiversity in India. Situated in the foothills of the Himalaya, it is spread across India and Nepal. We describe the herpetofauna of the western part of TAL encompassing Ramnagar Forest Division, which falls in Uttarakhand state of India. We primarily used visual encounter survey method for sampling. A total of 47 species of herpetofauna belonging to three orders, 17 families and 36 genera were recorded from 10 habitat types (6 terrestrial and 4 aquatic). Highest species richness (n=32) was recorded from the human settlement and least (n=4) species richness was reported from pond habitat. In this paper, the diversity of amphibians and reptiles in each habitat type is discussed.
Association of Vascular Properties With the Brain White Matter Hyperintensity in Middle‐Aged Population
Authors: Hannawi Yousef , Vaidya Dhananjay , Yanek Lisa R. , Johansen Michelle C. , Kral Brian G. , Becker Lewis C. , Becker Diane M. , Nyquist Paul A. 
Published: May 2022

Background
The periventricular white matter is more sensitive to the systemic hemodynamic alterations than the deep white matter because of differences in its vascular structure and systemic circulation relationship. We hypothesize that periventricular white matter hyperintensity (PVWMH) volume shows greater association than deep white matter hyperintensity (DWMH) volume with vascular properties (VPs) reflecting arterial stiffness and cardiovascular remodeling, indicators of the systemic circulation.

Methods and Results

A total of 426 participants (age, 59.0±6.1 years; 57.5% women; and 39.7% Black race) in the Genetic Study of Atherosclerosis Risk who were aged ≥50 years and had brain magnetic resonance imaging were studied. VPs included pulse pressure, hypertensive response to exercise, diastolic brachial artery diameter, diastolic common carotid artery diameter, common carotid artery distensibility coefficient, and left ventricular function. The relative associations of VPs with PVWMH and DWMH as multiple measures within the same individual were determined using multilevel linear models. We also determined if age modified the differences in VPs associations with PVWMH and DWMH. Our findings indicated that, within the same subject, PVWMH volume had greater association than DWMH volume with pulse pressure (
P
=0.002), hypertensive response to exercise (
P
=0.04), diastolic brachial artery diameter (
P
=0.012), and diastolic common carotid artery diameter (
P
=0.04), independent of age and cardiovascular risk factors. The differences of PVWMH versus DWMH associations with VPs did not differ at any age threshold.

Conclusions
We show, for the first time, that PVWMH has greater association than DWMH, independent of age, with vascular measurements of arterial stiffness and cardiovascular remodeling suggesting that changes in the systemic circulation affect the PVWMH and DWMH differently.
Marital Status and Subclinical Coronary Atherosclerosis in Asymptomatic Individuals
Authors: Ann Soe Hee , Lee Hyeji , Park Kyung Sun , Jeon Young‐Jee , Park Eun Ji , Park Sangwoo , Kim Yong‐Giun , Lee Yongjik , Choi Seong Hoon , Kwon Woon Jung , Park Gyung‐Min 
Published: May 2022

Background
Data are limited on the association between marital status and subclinical coronary atherosclerosis. This study investigated the influence of marital status on subclinical coronary atherosclerosis detected by coronary computed tomographic angiography in an asymptomatic population.

Methods and Results

This retrospective study analyzed 9288 asymptomatic individuals (mean age, 53.7±8.0 years; 6041 [65%] men) with no history of coronary artery disease who voluntarily underwent coronary computed tomographic angiography during a general health examination. Marital categories were married (n=8481) versus unmarried (n=807), comprising never married (n=195), divorced (n=183), separated (n=119), and widowed (n=310) individuals. The degree and extent of subclinical coronary atherosclerosis were evaluated by coronary computed tomographic angiography; ≥50% diameter stenosis was defined as significant. Logistic regression and propensity score matching analyses were used to determine the association between marital status and subclinical coronary atherosclerosis. After adjustment for cardiovascular risk factors, no significant differences were observed in the adjusted odds ratio (OR) of unmarried status for any coronary plaque (OR, 1.077; 95% CI, 0.899–1.291), calcified plaque (OR, 1.058; 95% CI, 0.881–1.271), noncalcified plaque (OR, 0.966; 95% CI, 0.691–1.351), mixed plaque (OR, 1.301; 95% CI, 0.884–1.917), and significant coronary artery stenosis (OR, 1.066; 95% CI, 0.771–1.474). Similarly, in the 2:1 propensity‐score matched population (n=2398), no statistically significant differences were observed for the OR of marital status for any subclinical coronary atherosclerosis (
P
>0.05 for all).

Conclusions
In this large cross‐sectional study, marital status was not associated with an increased risk of subclinical coronary atherosclerosis.
Cerebral Circulation Time After Thrombectomy: A Potential Predictor of Outcome After Recanalization in Acute Stroke
Authors: Wang Jia‐Qi , Wang Ying‐Jia , Qiu Jin , Li Wei , Sun Xian‐Hui , Zhao Yong‐Gang , Liu Xin , Zhao Zi‐Ai , Liu Liang , Nguyen Thanh N. , Chen Hui‐Sheng 
Published: May 2022

Background
Despite successful recanalization, up to half of patients with acute ischemic stroke caused by large‐vessel occlusion treated with endovascular treatment (EVT) do not recover to functional independence. We aim to evaluate the role of cerebral circulation time (CCT) as outcome predictor after EVT.

Methods and Results

We retrospectively enrolled consecutive patients with acute ischemic stroke–large‐vessel occlusion undergoing EVT. Three categories of CCT based on digital subtraction angiography were studied: CCT of the stroke side, CCT of the healthy side), and change of CCT of the stroke side versus CCT of the healthy side. Dramatic clinical recovery was defined as a 24‐hour National Institutes of Health Stroke Scale score ≤2 or ≥8 points drop. A modified Rankin Scale score ≤2 at 3 months was considered a favorable outcome. Logistic regression analysis was performed to evaluate the prediction of CCT on prognosis. One hundred patients were enrolled, of which 38 (38.0%) experienced a dramatic clinical recovery and 43 (43.0%) achieved a favorable outcome. Logistic regression analysis found that shorter change of CCT of the stroke side versus CCT of the healthy side and CCT of the stroke side were independent positive prognostic factors for dramatic clinical recovery (odds ratio [OR], 0.189;
P
=0.033; OR, 0.581;
P
=0.035) and favorable outcomes (OR, 0.142;
P
=0.020; OR, 0.581;
P
=0.046) after adjustment for potential confounders. A model including the change of CCT of the stroke side versus CCT of the healthy side also had significantly higher area under the curve values compared with the baseline model in patients with dramatic clinical recovery (0.780 versus 0.742) or favorable outcome (0.759 versus 0.713).

Conclusions
To our knowledge, this is the first report that CCT based on digital subtraction angiography data exhibits an independent predictive performance for clinical outcome in patients with acute ischemic stroke–large‐vessel occlusion after EVT. Given that this readily available CCT can provide alternative perfusion information during EVT, a prospective, multicenter trial is warranted.
Observation Impact and Information Retention in the Lower Troposphere of the GMAO GEOS Data Assimilation System
Authors: Zhu Yanqiu , Todling Ricardo , Arnold Nathan 
Published: May 2022

Abstract
In this study, we have assessed the effectiveness of the use of existing observing systems in the lower troposphere in the GEOS hybrid–4DEnVar data assimilation system through a set of observing system experiments. The results show that microwave radiances have a large impact in the Southern Hemisphere and tropical ocean, but the large influence is mostly observed above 925 hPa and dissipates relatively quickly with longer forecast lead times. Conventional data information holds better in the forecast ranging from the surface to 100 hPa, depending on the field evaluated, in the Northern Hemisphere and lowest model levels in the tropics. Infrared radiances collectively have much less impact in the lower troposphere. Removing surface observations has small but persistent impact on specific humidity in the upper atmosphere, but small or negligible impact on planetary boundary layer (PBL) height and temperature. The model responses to the incremental analysis update (IAU) forcing are also analyzed. In the IAU assimilation window, the physics responds strongly to the IAU forcing in the lower troposphere, and the changes of physics tendency in the lower troposphere and hydrodynamics tendency in the mid- and upper troposphere are viewed as beneficial to the reduction of state error covariance. In the subsequent forecast, the model tendencies continue to deviate further from the original free forecast with forecast lead times around 300–400 hPa, but physics tendency has showed signs of returning to its original free forecast mechanisms at 1-day forecast in the lower troposphere.
Local Administration of Metformin Improves Bone Microarchitecture and Biomechanical Properties During Ruptured Canine Achilles Tendon–Calcaneus Interface Healing
Authors: Shi Qiang , Zhang Tao , Chen Yang , Xu Yan , Deng Zhenhan , Xu Daqi 
Published: May 2022

Background: Tendon-bone interface (TBI) healing is a clinical dilemma that is closely relevant to new bone formation and remodeling at the repair site. Previous studies showed that metformin is an osteogenic inducer for stem cells in vitro and capable of stimulating bone regeneration in vivo. Hypothesis: Metformin would be effective for promoting TBI healing by enhancing new bone formation and remodeling. Study Design: Controlled laboratory study. Methods: Canine bone marrow stem cells (BMSCs) were cultured with various concentrations of metformin (0, 10, 50, 100, 200 μM). The effect of metformin on the osteogenic differentiation of canine BMSCs was evaluated via alizarin red staining and osteogenic gene expression. Eighteen mature beagles were included in a bilateral Achilles tendon–calcaneus (ATC) interface injury model. The right interface was reattached via surgical repair only, while the left was surgically reattached after implanting a fibrin glue containing metformin. At postoperative week 4 or 8, the healing quality of the wounded ATC interfaces was evaluated. Results: In vitro experiments determined that metformin was an osteogenic inducer for canine BMSCs. In vivo experiments showed that the metformin-treated ATC interfaces were repaired with significantly greater failure load and stiffness than was the no-metformin control site ( P < .05 for all). Micro–computed tomography analysis showed that the metformin-treated specimens presented significantly higher bone volume/total volume and trabecular thickness than did the no-metformin control specimens ( P < .05 for all), as confirmed via hematoxylin and eosin staining. Immunohistochemical staining showed that significantly more osteocalcin-positive cells were located at the newly formed bones treated with metformin than at the no-metformin control site at week 4 ( P < .05). Masson trichrome staining showed that significantly more oriented collagen fibers anchored into the newly formed bone of the metformin-treated site than the no-metformin control site ( P < .05). Conclusion: Metformin induced the osteogenesis of canine BMSCs in vitro, and local administration of metformin provided an improvement of bone microarchitecture at the calcaneus as well as an increase in the tensile properties of the repaired ATC interfaces in canines. Clinical Relevance: Findings of the study indicate that local administration of metformin may be an effective strategy for TBI healing in clinic.
Prevalence of chronic cough and patient characteristics in adults in Spain: A population-based cross-sectional survey
Authors: Domínguez-Ortega Javier , Plaza Vicente , Li Vicky W , Fonseca Eileen , Cea-Calvo Luis , Martin Ashley , Sánchez-Jareño Marta , Brady Joanne E , Schelfhout Jonathan 
Published: May 2022

Background Chronic cough (CC) represents a significant health burden. This study assessed the prevalence of CC (defined as per international guidelines as cough duration >8 weeks) in Spanish adults and compared characteristics between CC and non-CC cohorts. Methods CC cohorts were compiled using data from adult respondents to the 2020 Spanish cross-sectional online National Health and Wellness Survey (NHWS). Using propensity scores, respondents experiencing CC during their lifetime and the previous 12 months were matched 3:1 to respondents without CC and their health characteristics were compared. The number of Spanish adults affected with CC was estimated using weighted CC prevalence. Results CC during their lifetime or the previous 12 months was experienced by 579 (8.2%) and 389 (5.5%) of 7074 NHWS respondents, of whom 233 (38.5%) and 171 (44.0%), respectively, had physician-diagnosed CC. Based on weighted prevalence rates, lifetime and 12-month CC were estimated to affect ≈3.3 million and ≈2.2 million Spanish adults, respectively. Relative to the non-CC cohort, the 12-month CC cohort consistently demonstrated poorer health status, poorer mental health, greater healthcare utilization, and lower productivity at work and home. Conclusion This study contributes novel data regarding the prevalence of CC in Spain, suggests that CC is underdiagnosed, and reflects that CC and related comorbidities inflict a significant health burden in the affected population.
Paper 03: Multimodal Pain Regimen is Equivalent to Opioid Analgesia Following Arthroscopic Rotator Cuff Surgery: A Prospective Randomized Controlled Trial
Authors: Abbas Muhammad , Okoroha Kelechi , Moutzouros Vasilios , Jildeh Toufic 
Published: May 2022

Objectives: To evaluate the efficacy of a multimodal non-opioid analgesic protocol in controlling postoperative pain compared to opioids following a primary arthroscopic rotator cuff repair. Methods: Seventy consecutive patients undergoing a primary rotator cuff repair were assessed eligibility. A prospective randomized controlled trial was designed in accordance with the Consolidated Standards of Reporting Trials 2010 (CONSORT) statement. The two arms of the study included a multimodal non-opioid pain regimen for the experimental group, and a standard of care narcotics for the control group. The primary outcome was visual analog scale (VAS) pain scores for the first ten postoperative days. Secondary outcomes included PROMIS-PI, patient satisfaction, and adverse drug events. Patients were randomized using a random number generator. Whiles patients were not blinded to their treatment group, all reported outcomes were collected by blinded observers. Results: Twenty-six patients either declined to participate or were excluded from the study. Forty-four patients were included in the final analysis. A total of 27 patients were in the traditional group and 17 patients were in the nonopioid group. Patients in the traditional pain control group reported a significantly lower VAS pain score on post-operative day 1 (opioid: 5.7 ± 2, nonopioid: 3.7 ± 2.2, p=0.011) and post-operative day 4 (opioid: 4.4 ± 2.7, nonopioid: 2.4 ± 2.2, p=0.023). No significant difference was seen on any other postoperative day. When mixed measured models were used to control for confounding factors the non-opioid group demonstrated significantly lower VAS and PROMIS-PI scores (p<0.01) at every time point. The most commonly reported side effects for patients in both groups were drowsiness (opioid: 2.7 ± 3.3 days, nonopioid: 1.9 ± 3.3 days) and constipation (opioid: 2.2 ± 2.9 days, nonopioid: 0.2 ± 0.6 days). Patients in the traditional analgesia group reported significantly greater average number of days with constipation (opioid: 2.2 ± 2.9, nonopioid: 0.2 ± 0.6, p=0.003) and days with upset stomach (opioid: 1.3 ± 2.5, nonopioid: 0.0 ± 0.0, p=0.020) than those in the nonopioid group. Conclusions: This study found that a multimodal nonopioid pain protocol provided at least equivalent pain control compared to traditional opioid analgesics in patients undergoing primary arthroscopic rotator cuff repair. Minimal side effects were noted with some improvement in the multimodal nonopioid pain cohort, and all patients reported satisfaction with their pain management.
Paper 13: None: Clinical Outcomes of Ulnar Collateral Ligament Surgery in Non-Throwing Athletes
Authors: Rothermich Marcus 
Published: May 2022

Objectives: Ulnar collateral ligament (UCL) surgery continues to improve since its inception by Dr. Frank Jobe in 1974. There is now ample data on the outcomes of surgery for throwing athletes, such as baseball players, who undergo either UCL reconstruction or UCL repair. In comparison, there is very little available data regarding outcomes of UCL surgery for non-throwing athletes who are seeking similar benefit from the procedure. The primary objective of this study is to provide clinical outcomes of UCL surgery performed in non-throwing athletes at a single institution with a minimum two-year follow-up. Methods: Forty non-throwing athletes who underwent UCL surgery (repair or reconstruction) between 2011 and 2019 were identified. All surgeries were performed by one of three fellowship-trained sports medicine surgeons at our institution utilizing a uniform technique for repair or reconstruction. Demographics were recorded including age, sex, laterality, arm dominance, sport, level of competition, and type of surgery (UCL repair or reconstruction). Outcomes included return to play (rate and average time), American Shoulder and Elbow Surgeons (ASES) scores, and complications. Results: Thirty-seven patients (92.5%) were available for evaluation with a minimum two-year follow-up consisting of 16 males (43%) and 21 females (57%). Mean age at the time of surgery was 18±3.7 years.28 UCL repairs (76%) and 9 UCL reconstructions (24%) were performed.Sports included football (n=11), gymnastics (11), cheerleading (7), wrestling (4), volleyball (2), basketball (1), and acrobatics (1). Quarterbacks were excluded from the football patients as quarterbacks are throwing athletes. Level of competition included youth (1), high school (26), college (8), and professional (2).Return to play rate was 93% (26 of 28) at a mean of 7.4 months for UCL repair, and 100% (9 of 9) at a mean of 10 months for UCL reconstruction.Mean ASES scores were 94.4 and 98.7 for UCL repair and reconstruction, respectively.Two Patients in the UCL repair group required ulnar neurolysis and revision ulnar nerve transposition. Conclusions: Both UCL reconstruction and UCL repair show favorable outcomes at minimum two-year follow-up in non-throwing athletes.93% or greater returned to play with good functional outcomes and minimal complications. [Table: see text][Table: see text]