bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable development scores using spatial information systems-analytic hierarchy process
Authors: Abdullah Lazim , Mohd Najib Norliana 
Published: June 2022

PurposeThis research aims to develop sustainable development scores at districts level based on weights of thirteen sub-indicators using a spatial information system.Design/methodology/approachThe empirical study was conducted at seven districts in the state of Terengganu Malaysia. The evaluation was implemented using a spatial information system combined with weights of sub-indicators that were computed from the analytic hierarchy process (AHP) method.FindingsIn this study the sub-indicators layers overlaid into one raster layer to produce a sustainability development score from 1 to 3 for every district. The one raster layer shows that Marang district received the highest sustainable development score of 2.284. On the other hand, Kemaman district received the poorest sustainable development score of 1.686.Research limitations/implicationsIn this study the weights that obtained from the AHP method are verified and validated using a sensitivity analysis. The scores at districts level perhaps may not be accurate due to difficulties in differentiating the variability of indicators and sub-indicators. These are among the unsettled issues that could be explored as future research direction.Social implicationsThe results would have greatly benefited the policy makers and stakeholders, particularly in planning for future development without compromising the significance of environment, social and economic indicators.Originality/valueSustainable development is one of the key elements that needs to be considered seriously in assessing development of a country. The assessment may include proposing indices for environment, social, economic indicators and related sub-indicators of sustainable development. Instead of considering specific indices for indicators, this approach departs more formally from the concept of unweighted indices at country level.
Climatic Conditions and Lexis: Some Diachronic Notes on Weather‐Related Words in English and Other European Languages
Authors: Grzega Joachim 
Published: June 2022

AbstractFocusing on metalinguistic sources and passages with words from the conceptual field of weather in cooccurrence (and including language contrasts), the study analyses whether changes in weather‐related lexemes in English language history, particularly words for “weather, condition of the air,” “cloud,” and “mist,” may be related to climatic conditions. This is supported for the following cases: (1) the use of the lexeme for “weather” in the sense of “fair weather” in the so‐called Medieval Warm Period (950–1250); (2) changes among “cloud” words: welkin, cloud, sky, and rack “mass of cloud moving quickly” toward or at the beginning of the Little Ice Age (1250s–1450); and (3) changes among “mist” words: the revived rime “hoar frost, frozen mist, chill mist, or fog,” the metaphorical use of fog “long grass left uncut” for “thick clouds of water vapor” and the figurative use of haze “body of dust” for “fog, thick mist” during the Tudor Inflation (1525–1600).
In Love with Social Order: William Allen and the ‘Science’ and ‘Art’ of Early Nineteenth‐Century British Philanthropy
Authors: Cazzola Matilde 
Published: June 2022

AbstractThis article surveys the charitable and humanitarian activities of the Quaker philanthropist William Allen (1770–843), who was at the forefront of several campaigns for the relief and schooling of the poor and labouring classes in Britain and the emancipation and ‘civilisation’ of the enslaved and colonised peoples in the broader empire between the late eighteenth and the mid‐nineteenth centuries. By focusing on the first series of Allen's periodical The Philanthropist (1811–19), the essay sheds light on the underlying principles of early nineteenth‐century philanthropy as programmatically different from the motivations of traditional private charity. Understood as a political yet nonstate activity, associational philanthropy demarcated the space of civil society as the field where the middle classes, still excluded from the franchise, could impact state legislation and public policies. As they shared the same critical views as political economists on the statutory system of the Poor Laws, these philanthropists played a crucial role in enlarging the ‘scale’ of social policy‐making from the parish to the nation in the early nineteenth century. The article argues that even though they were religiously inspired, Allen and his associates understood philanthropy as a secular pursuit aimed at promoting material welfare and incrementing the utilitarian ‘stock of happiness’ of society. As such, philanthropy was even explicitly conceptualised as a ‘social science’, which, being driven by a love for an ordered society rather than for other men, prescribed the policies to be adopted by the ‘art’ of government.
MicroRNA miR‐2765‐3p regulates reproductive diapause by targeting FoxO in Galeruca daurica
Authors: Duan Tian‐Feng , Li Ling , Wang Hai‐Chao , Pang Bao‐Ping 
Published: June 2022

AbstractThe forkhead box O (FoxO), as a conserved transcription factor, plays an indispensable role in regulating insect diapause. However, how FoxO is regulated to control diapause in insects remains unknown. In this study, we discovered functional binding sites for miR‐2765‐3p in the 3′ untranslated region of FoxO in Galeruca daurica. The luciferase reporter assay showed that miR‐2765‐3p targeted FoxO and suppressed its expression. The expression profiles of miR‐2765‐3p and FoxO displayed opposite patterns during the female developmental process. Overexpression of miR‐2765‐3p by the injection of the miR‐2765‐3p agomir into adult females reduced FoxO expression, leading to the suppression of lipid accumulation, promotion of ovarian development, and inhibition of reproductive diapause. This is similar to the phenotype that results from the depletion of FoxO by injecting dsFoxO into adult females. In addition, the repression of miR‐2765‐3p by injecting the miR‐2765‐3p antagomir increased the FoxO transcript level, leading to the stimulation of lipid accumulation, depression of ovarian development, and induction of reproductive diapause. A hormone injection assay showed that the juvenile hormone (JH) agonist (methoprene) upregulated miR‐2765‐3p and downregulated FoxO. Notably, injecting methoprene rescued ovarian development defects associated with miR‐2765‐3p inhibition. These findings indicate that the JH/miR‐2765‐3p/FoxO axis plays a vital role in the regulation of reproductive diapause in G. daurica.
A dynamic nomogram for predicting survival among diabetic patients on maintenance hemodialysis
Authors: Chen Ying , Wang Yao , Shen Yan , Dai Houyong , Huang Xinzhong , Fang Li , Huang Xi , Shen Yi , Yuan Li 
Published: June 2022

AbstractIntroductionAmong maintenance hemodialysis (MHD) patients, ones with diabetes mellitus (DM) are known to have the worst outcome.MethodsA total of 263 MHD patients were included, a dynamic nomogram was established based on multivariable Cox regression analysis.ResultsThe median overall survival (OS) time was 46 months. The 1‐, 3‐, and 5‐year OS rates were 90.9%, 70.5% and 53.9%, respectively. The multivariable Cox regression analysis indicated that DM duration, cardiovascular complication, baseline values before starting MHD for estimated glomerular filtration rate and serum phosphate were independent risk factors. The C‐index of the dynamic nomogram was 0.745 and the calibration curves showed optimal agreement between the model prediction and actual observation for predicting survival probabilities.ConclusionsOur study was the first to establish dynamic nomogram among diabetic MHD patients, the fast and convenient online tool can be used for individual risk estimation at the point of prognosis prediction.
Environmental nucleic acids: A field‐based comparison for monitoring freshwater habitats using eDNA and eRNA
Authors: Littlefair Joanne E. , Rennie Michael D. , Cristescu Melania E. 
Published: June 2022

AbstractNucleic acids released by organisms and isolated from environmental substrates are increasingly being used for molecular biomonitoring. While environmental DNA (eDNA) has received much attention, the potential of environmental RNA as a biomonitoring tool remains under‐explored. Several recent studies using paired DNA and RNA metabarcoding of bulk samples suggest that RNA might better reflect “metabolically active” parts of the community. However, such studies mainly capture organismal eDNA and eRNA. For larger eukaryotes, isolation of extra‐organismal RNA will be important, but viability needs to be examined in a field‐based setting. In this study we evaluate (a) whether extra‐organismal eRNA release from macroeukaryotes can be detected given its supposedly rapid degradation, and (b) if the same field collection methods for eDNA can be applied to eRNA. We collected eDNA and eRNA from water in lakes where fish community composition is well documented, enabling a comparison between the two nucleic acids in two different seasons with monitoring using conventional methods. We found that eRNA is released from macroeukaryotes and can be filtered from water and metabarcoded in a similar manner as eDNA to reliably provide species composition information. eRNA had a small but significantly greater true positive rate than eDNA, indicating that it correctly detects more species known to exist in the lakes. Given relatively small differences between the two molecules in describing fish community composition, we conclude that if eRNA provides significant advantages in terms of lability, it is a strong candidate to add to the suite of molecular monitoring tools.
The role of central serotonergic markers and estradiol changes in perinatal mental health
Authors: Borgsted Camilla , Høgh Stinne , Høgsted Emma Sofie , Fonnesbech‐Sandberg Laura , Ekelund Kim , Albrechtsen Charlotte Krebs , Wiis Julie Therese , Hegaard Hanne , Cvetanovska Eleonora , Juul Anders , Frederiksen Hanne , Pinborg Anja , Weikop Pia , Frokjaer Vibe 
Published: June 2022

AbstractObjectiveWomen have an increased risk for mental distress and depressive symptoms in relation to pregnancy and birth. The serotonin transporter (SERT) may be involved in the emergence of depressive symptoms postpartum and during other sex‐hormone transitions. It may be associated with cerebrospinal fluid (CSF) levels of the main serotonin metabolite 5‐hydroxyindolacetic acid (5‐HIAA). In 100 healthy pregnant women, who were scheduled to deliver by cesarean section (C‐section), we evaluated 5‐HIAA and estradiol contributions to mental distress 5 weeks postpartum.MethodsEighty‐two women completed the study. CSF collected at C‐section was analyzed for 5‐HIAA, with high performance liquid chromatography. Serum estradiol concentrations were quantified by liquid chromatography tandem mass spectrometry before C‐section and postpartum. Postpartum mental distress was evaluated with the Edinburgh Postnatal Depression Scale (EPDS). Associations between EPDS, 5‐HIAA, and Δestradiol were evaluated in linear regression models adjusted for age, parity and SERT genotype.ResultsHigher levels of postpartum mental distress symptoms were negatively associated with a large decrease in estradiol concentrations (βΔE2 = 0.73, p = 0.007) and, on a trend level, positively associated with high antepartum 5‐HIAA levels (β5‐HIAA = 0.002, p = 0.06).ConclusionIn a cohort of healthy pregnant women, postpartum mental distress was higher in women with high antepartum 5‐HIAA (trend) and lower in women with a large perinatal estradiol decrease. We speculate that high antepartum 5‐HIAA is a proxy of SERT levels, that carry over to the postpartum period and convey susceptibility to mental distress. In healthy women, the postpartum return to lower estradiol concentrations may promote mental well‐being.
High adult mortality and failure of recruitment in a population of Banksia spinulosa following high‐intensity fire
Authors: Whelan Robert J. , Ayre David J. 
Published: June 2022

ABSTRACTSerotinous plants that both release seed and resprout after fire are thought to be resistant to wildfires within the range of intensities that have been experienced up until now. However, the frequency and scale of intense wildfires is increasing under climate change. We studied annual flowering and fruit‐set in a large population of Banksia spinulosa plants in south‐eastern Australia from the early 1990s to 2006. The results led us to predict that there would be little recruitment from seedlings after the next fire but good resprouting from very long‐lived lignotubers. Our study population burned in the widespread, high‐intensity wildfires of December 2019, providing an opportunity to test the hypothesis. Most above‐ground stems and cones were reduced to ash, and only 15 cones (on 10 plants) remained after the fire. We found no seedlings in the 0.3 ha site that had initially contained over 350 adult plants. Little natural mortality had been observed pre‐fire, but by 5 months after the fire, nearly 25% of lignotubers had failed to resprout. We conclude that even common and widespread resprouting species will suffer population decline and reduced genetic diversity as high‐intensity fires become more extensive and frequent.
Analysis of the movements generated by a multi‐field functional electrical stimulation device for upper extremity rehabilitation
Authors: Martín‐Odriozola Aitor , Rodríguez‐de‐Pablo Cristina , Caceres‐Salegi Ane , García‐Calleja Andrea , Marín‐Ojea Juan Ignacio , Hernández Erik , Imatz‐Ojanguren Eukene , Keller Thierry , Zabaleta‐Rekondo Haritz 
Published: June 2022

AbstractBackgroundThe most common chronic sequela after stroke is the loss of arm function, and functional electrical stimulation (FES) applied to the forearm muscles is one of the options to treat it. Surface multi‐field electrodes have emerged, showing a great potential to improve the selectivity of the stimulation, delay muscle fatigue, and provide easier donning and doffing. The muscular selectivity takes on special relevance in the rehabilitation of the upper extremity as hand dexterity requires a wide diversity of specific muscle actions.MethodsThis pilot study analyses the movements generated in the wrist and fingers using a commercial multi‐field technology‐based FES device (Fesia Grasp). The study included five patients with hemiplegic subacute stroke, in which scanning of all cathodes of the electrode was carried out daily for 5 days, in two different forearm positions, with the resulting movements being labeled by experienced therapists.ResultsThe aim of this pilot study was to determine if there were differences between subjects and between forearm positions in terms of produced movements. Movements of the wrist (two movements) and the fingers (six movements) could be achieved in two different forearm positions.ConclusionsThe multi‐field electrode of Fesia Grasp enables to generate a wide range of movements of the hand in different positions. This fact could allow to produce more physiological movement patterns during the rehabilitation process with FES, which could have a beneficial effect on the recovery of patients with neurological diseases.
Nonparametric Inference of General While-Alive Estimands for Recurrent Events
Authors: Mao Lu 
Published: June 2022

Abstract
Measuring the treatment effect on recurrent events like hospitalization in the presence of death has long challenged statisticians and clinicians alike. Traditional inference on the cumulative frequency unjustly penalizes survivorship as longer survivors also tend to experience more adverse events. Expanding a recently suggested idea of the “while-alive” event rate, we consider a general class of such estimands that adjust for the length of survival without losing causal interpretation. Given a user-specified loss function that allows for arbitrary weighting, we define as estimand the average loss experienced per unit time alive within a target period and use the ratio of this loss rate to measure the effect size. Scaling the loss rate by the width of the corresponding time window gives us an alternative, and sometimes more photogenic, way of showing the data. To make inferences, we construct a nonparametric estimator for the loss rate through the cumulative loss and the restricted mean survival time and derive its influence function in closed form for variance estimation and testing. As simulations and analysis of real data from a heart failure trial both show, the while-alive approach corrects for the false attenuation of treatment effect due to patients living longer under treatment, with increased statistical power as a result. The proposed methods are implemented in the R-package WA, which is publicly available from the Comprehensive R Archive Network (CRAN).
A non‐retinol retinoic acid receptor‐γ (RAR‐γ/NR1B3) selective agonist, tectorigenin, can effectively inhibit the ultraviolet A‐induced skin damage
Authors: Dai Xintong , Jin Jing , Jia Yan , Yang Kai , Han Jingxia , Zhang Zhiyuan , Ding Xiujuan , Yao Cheng , Sun Tao , Zhu Caibin , Liu Huijuan 
Published: June 2022

Background and PurposeLong‐term ultraviolet (UV) exposure can cause inflammation, pigmentation and photoaging. All‐trans retinoic acid (ATRA/tretinoin) is a commonly used retinoic acid receptor (RAR) agonist in the clinical treatment of UV‐induced skin problems. However, the use of such drugs is often accompanied by systemic adverse reactions caused by nonspecific activation of RARs. Therefore, this study was designed to screen for a novel RAR‐γ‐selective agonist with high safety.Experimental ApproachMolecular docking, dynamic simulation and Biacore were used to screen and identify novel RAR‐γ‐selective agonists. RT‐PCR, ELISA, western blotting, immunofluorescence staining, flow cytometry and proteomic analysis were used to detect the effects of these novel RAR‐γ selective agonists on UVA‐induced inflammation and photoaging cell models. UVA‐induced mouse models were used to evaluate the effects of tectorigenin on skin repair, ageing and inflammation.Key ResultsTectorigenin is a novel RAR‐γ‐selective agonist, which inhibits UV‐induced oxidative damage, inflammatory factor release and matrix metalloproteinase (MMP) production. Tectorigenin can also reverse the UVA‐induced loss of collagen. The results of the signalling pathway research showed that tectorigenin mainly affects the MAPK/JNK/AP‐1 pathway. In animal experiments, tectorigenin showed better anti‐inflammatory and anti‐photoaging effects, and caused less skin irritation than ATRA. Nano‐particle loaded tectorigenin significantly improved the utilization of tectorigenin.Conclusions and ImplicationsTectorignen is a non‐retinol RAR‐γ‐selective agonist that can inhibit UV‐induced skin damage and could be developed as a safe pharmaceutical component for the prevention of photoaging and skin inflammation.
Effectiveness of human papillomavirus vaccine against cervical precancer in Japan: Multivariate analyses adjusted for sexual activity
Authors: Kudo Risa , Sekine Masayuki , Yamaguchi Manako , Hara Megumi , Hanley Sharon J. B. , Kurosawa Megumi , Adachi Sosuke , Ueda Yutaka , Miyagi Etsuko , Ikeda Sayaka , Yagi Asami , Enomoto Takayuki 
Published: June 2022

AbstractJapanese girls aged 12–16 years are offered free human papillomavirus (HPV) vaccination and cervical cancer screening is conducted with cytology and not HPV testing from the age of 20 years. So far, no study has analyzed the effect of HPV vaccination against cervical precancers considering HPV infection status and sexual activity. We aimed to analyze the vaccine effectiveness (VE) against HPV infection and cytological abnormalities, adjusted for sexual activity. This study comprised women aged 20–26 years who underwent cervical screening in Niigata. We obtained HPV vaccination status from municipal records and a questionnaire along with information concerning sexual activity. Of 5194 women registered for this study, final analyses included 3167 women in the vaccinated group (2821 vaccinated women prior to sexual debut) and 1386 women in the unvaccinated group. HPV 16/18 (0.2% vs 3.5%), 31/45/52 (3.4% vs 6.6%), and 31/33/45/52/58 (5.0% vs 9.3%) positive rates were significantly lower in the vaccinated group (P < 0.001). No women vaccinated before sexual debut had HPV 16/18‐related cytological abnormalities. VE for HPV 16/18 infection and high‐grade cytological abnormalities in women vaccinated prior to sexual debut were 95.8% (95% CI 81.9–99.0%; P < 0.001) and 78.3% (95% CI 11.3–94.7%; P = 0.033), respectively, in multivariate analyses adjusted for age and number of sexual partners. However, analyses of all vaccinated women did not show significant effectiveness against cytological abnormalities. Our results showed the effectiveness of HPV vaccine against high‐grade cervical cytological abnormalities and the importance of the vaccination before sexual debut.
Upregulation of miR‐144‐3p alleviates Doxorubicin‐induced heart failure and cardiomyocytes apoptosis via SOCS2/PI3K/AKT axis
Authors: Zhang Donglin , Pan Aiqin , Gu Jianke , Liao Renfeng , Chen Xueyu , Xu Zhaozhu 
Published: June 2022

AbstractMicroRNAs (miRs) are implicated in heart failure (HF). Thereby, we aim to uncover the role of miR‐144‐3p in HF. Doxorubicin (Dox)‐induced HF model was constructed in rats and cardiomyocytes H9C2, and the cardiac function was determined using ultrasound cardiogram. Morphology of cardiac tissue was observed using hematoxylin–eosin (H&E) staining. The viability and apoptosis of Dox‐treated and transfected cardiomyocytes were determined using Cell Counting Kit‐8 (CCK‐8) assay and flow cytometry. Relative expressions of the HF‐associated miRs (including miR‐144‐3p), suppressor of cytokine signaling 2 (SOCS2), apoptosis‐ and phosphoinositide 3‐kinase (PI3K)/AKT pathway‐related factors (B‐cell lymphoma 2, Bcl‐2; Bcl‐2 associated X protein, Bax; cleaved [C] capsase‐3; phosphoinositide 3‐kinase, PI3K; phosphorylated‐PI3K, p‐PI3K; p‐AKT; AKT) were measured with quantitative real‐time polymerase chain reaction or Western blot. Target gene of miR‐144‐3p was predicted by Starbase and TargetScan and confirmed with dual‐luciferase reporter assay. Dox caused rat cardiac dysfunction, aggravated cardiac injury, decreased cardiomyocytes viability, and the expression of miR‐144‐3p, Bcl‐2, and phosphorylation of both PI3K and AKT yet the upregulated those of Bax and C caspase‐3, which was reversed by upregulating miR‐144‐3p, whereas downregulating miR‐144‐3p did oppositely. SOCS2 was the target gene of miR‐144‐3p, Dox promoted SOCS2 expression, which was reversed by upregulating miR‐144‐3p, while downregulating miR‐144‐3p did conversely. In addition, silencing SOCS2 reversed the effects of miR‐144‐3p downregulation in Dox‐treated cardiomyocytes. Upregulating miR‐144‐3p alleviated Dox‐induced cardiac dysfunction and cell apoptosis via targeting SOCS2, providing a novel evidence of miR‐144‐3p in HF.
Cross-cultural assessment of the impact of eczema in six countries with different lifestyles
Authors: Merhand Stéphanie , Taieb Charles 
Published: June 2022

Abstract
Atopic dermatitis or eczema is a common skin disease in children but also in adults; in Europe alone, it affects more than 23 million adults. At the time of internationalization of studies, it seems important to know that the impact of eczema is different according to lifestyle. It seems that the use of two patient-reported outcomes, one specific, the other not, to measure the impact of eczema is relevant and should be recommended.