bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complement 3 Is a Potential Biomarker for Cerebral Amyloid Angiopathy
Authors: Saito Satoshi , Yamashiro Takayuki , Yamauchi Miho , Yamamoto Yumi , Noguchi Michio , Tomita Tsutomu , Kawakami Daisuke , Shikata Masamitsu , Tanaka Tomotaka , Ihara Masafumi 
Published: July 2022

Background: Cerebral amyloid angiopathy is a cerebrovascular disease directly implicated in Alzheimer’s disease pathogenesis through amyloid-β deposition. Growing evidence has shown a pivotal role of chronic neuroinflammation both in cerebral amyloid angiopathy and Alzheimer’s disease. Objective: The aim of this study was to investigate whether circulating levels of the complement 3, a crucial component of the innate immune system, are increased in patients with cerebral amyloid angiopathy. Methods: Serum complement 3 levels were retrospectively measured by a sandwich enzyme-linked immunosorbent assay in a single-center cohort of patients with mild cognitive impairment. The diagnosis of cerebral amyloid angiopathy was based on the modified Boston criteria. Logistic regression analysis was performed to identify the predictive factors for cerebral amyloid angiopathy. Results: We analyzed 55 mild cognitive impairment patients (mean age [standard deviation]: 76.3 [6.8] years; 33 [60% ] men). Complement 3 levels were significantly increased in cerebral amyloid angiopathy patients ( n = 16) compared with those without cerebral amyloid angiopathy ( n = 39) (median [interquartile range]: 0.43 [0.34–0.65] versus 0.35 [0.25–0.45], respectively; p = 0.040). Univariate and multivariate logistic regression analysis revealed that increased complement 3 levels were significantly associated with cerebral amyloid angiopathy. After selection of the best predictive model using stepwise selection, complement 3 was preserved as a significant independent predictive factor for cerebral amyloid angiopathy (odds ratio per 0.1 unit/mL increase [95% confidence interval]: 1.407 [1.042–1.899]; p = 0.026). Conclusion: Complement activation may play a pivotal role in cerebral amyloid angiopathy. Complement 3 may be a novel diagnostic biomarker for cerebral amyloid angiopathy.
Reduced Hippocampal and Anterior Cingulate Expression of Antioxidant Enzymes and Membrane Progesterone Receptors in Alzheimer’s Disease with Depression
Authors: Luo Wendy , Pryzbyl Katherine J. , Bigio Eileen H. , Weintraub Sandra , Mesulam M.-Marsel , Redei Eva E. 
Published: July 2022

Background: Major depressive disorder (MDD) is a risk factor for dementia including that caused by Alzheimer’s disease (AD). Both MDD and AD have a higher prevalence in women than men, and estrogen-related processes have been implicated in this sex difference. Objective: To identify if enhanced oxidative stress and decreased expression of the memory enhancer insulin-like growth factor 2 ( IGF2), each implicated separately in MDD and AD, are exaggerated in individuals with both AD and MDD compared to those with AD. Methods: Expression of target genes are determined by qPCR in postmortem hippocampus (Hip) and anterior cingulate cortex (ACC) of individuals with dementia and autopsy confirmed AD and those of AD+MDD. Results: Transcript levels of the antioxidant enzymes catalase ( CAT) and superoxide dismutase 1 ( SOD1), as well as IGF2 and its receptor ( IGF2R) were significantly lower in the Hip and ACC of individuals with both AD and MDD compared to those with AD and no MDD. Expressions of Progestin and AdipoQ Receptor Family Member 7 ( PAQR7, alias progesterone receptor alpha, mPRa) and PAQR8 ( mPRβ), receptors that bind neurosteroids, were also lower in the Hip and ACC of AD+MDD samples compared to those of AD without MDD. Correlations among these transcripts revealed that estrogen receptor 2 ( ESR2) and mPR β are direct or indirect regulators of the expression of the antioxidant enzymes and IGF2R. Conclusion: Reduced levels of antioxidant enzymes, decreased IGF2 expression, and diminished estrogen or membrane progesterone receptor-dependent processes might be more pronounced in the subpopulation of individuals with AD and MDD than without MDD.
Proactive care post-discharge to reduce 30 day readmissions to hospital
Authors: Choudhury J. , Perrio S. , Scobell M. , Bertram T. , Gray A. 
Published: July 2022

BACKGROUND: Healthwatch England estimated emergency readmissions have risen by 22.8% between 2012–13 and 2016–17. Some emergency readmissions could be avoided by providing patients with urgent out of hospital medical care or support. Sovereign Health Network (SHN) comprises of three GP practices, with a combined population of 38,000. OBJECTIVE: We will decrease the number of SHN patients readmitted within 30 days of discharge from Portsmouth Hospitals Trust following a non-elective admission (excluding Emergency Department attendance) by 40–60% by July 2020. METHODS: Four Plan, Do, Study, Act (PDSA) cycles were used to test the administrative and clinical processes. Our Advanced Nurse Practitioner reviewed all discharge summaries, added alerts to records, and proactively contacted patients either by text, telephone or home visit. RESULTS: 92 patients aged 23 days to 97 years were admitted onto the recent discharge scheme. Half of discharge summaries were received on the day of discharge, whilst 29% of discharge summaries were received more than 24 hours post-discharge, and one was received 11 days post-discharge. Following our interventions, there were 55% less than expected readmissions during the same time period. CONCLUSION: To allow proactive interventions to be instigated in a timely manner, discharge summaries need to be received promptly. The average readmission length of stay following a non-elective admission is seven days. Our proactive interventions saved approximately 102.9 bed days, with potential savings of 1,775 bed days over a year. We feel the results from our model are promising and could be replicated by other Primary Care Networks to result in larger savings in bed days.
Documentation of Just in Case (JiC) medication for end of life patients in care homes looked after by a general practice
Authors: Barnes Eve , Parfit Caroline 
Published: July 2022

BACKGROUND: This project was undertaken to improve the documentation of Just in Case (JiC) medication in a general practice. The outcome of a Strengths, Weaknesses, Opportunities, Threats (SWOT) analysis highlighted this as an area where awareness within the practice could be improved. OBJECTIVE: A Plan-Do-Study-Act (PDSA) approach was taken to the project and involved collaborative working and data collection from the general practice and relevant care homes. METHOD: JiC medications are used to promptly manage symptoms experienced at the end of a patient’s life and are part of the Gold Standard Framework (2006). RESULTS: Of the patients registered at the practice with JiC medication, 37.5% were incorrectly documented. This included errors/ inaccuracy with the clinical coding, or the medication. Three patients on practice generated searches had no JiC medication in the care homes, and 4 patients had JiC boxes in the care home that was not identified by the search. CONCLUSION: This evaluation has identified documentation errors and discrepancies between practice and community records of JiC medication. A newly generated practice specific flowchart was created, with an aim of reducing the discrepancies. A guide of how to carry out a QI project like this was created for the RCGP and can be found on their website. A seminar at Bristol, North Somerset, and South Gloucestershire (BNSSG) CCG to present this project took place in 2021.
PERLINDUNGAN HUKUM TERHADAP PEMEGANG E-SERTIPIKAT TANAH DALAM PERATURAN ATR/BPN NO.1 TAHUN 2021
Authors: Surianto Daniel , Elbert Elbert , Fernando Gustianus 
Published: July 2022

Indonesia merupakan negara kepulauan yang memiliki sejumlah permasalahan salah satunya keterbatasan lahan tanah seperti sengketa tanah antar sesama penduduk dalam menguasai tanah. Untuk menyelesaikan permasalahan tersebut pemerintah mengeluarkan Permen ATR/BPN No.1 Tahun 2021 Tentang Sertipikat Elektronik. Akan tetapi timbul permasalahan yaitu perlindungan hukum bagi para pemegang E-Sertipikat Tanah. Sehingga dalam penelitian ini akan meninjau langsung dari sisi aspek hukum dan permasalahan sering terjadi serta solusi dari adanya permasalahan E-Sertipikat Tanah. Metode Penelitian yang digunakan Metode Yuridis Normatif dengan menggunakan pendekatan peraturan perundang-undangan yang berdasarkan bahan hukum primer dan sekunder. Hasil penelitian yang didapatkan masih banyaknya peraturan perundang- undangan yang tidak sesuai dalam mendukung kebijakan sertipikat tanah elektronik dan banyaknya tantangan yang harus dibenahi pemerintah berkaitan dengan penerbitan sertipikat tanah elektronik. Dalam implementasi penerbitan sertipikat tanah elektronik dapat menimbulkan dampak yang baru seperti pembuktian di pengadilan dan ke auntentikan suatu akta jual-beli yang akan melahirkan penerbitan sertipikat tanah elektronik. Dalam mendukung program pemerintah dalam penerbitan sertipikat tanah elektronik ada beberapa hal yang perlu dilakukan pemerintah seperti mengandeng Pakar keilmuan Informasi Teknologi (IT) dan Ilmu Hukum supaya dapat bisa saling melengkapi dalam penerbitan sertipikat tanah elektronik dan pemerintah wajib melakukan sosialisasi, bimbingan teknis dan penyuluhan. Terkait aturan penerbitan sertipikat tanah elektronik dengan demikian masyarakat akan mendapat perlindungan hukum yang lebih kuat dan aman berkaitan dengan sertipikat tanah elektronik.
PENERAPAN HUKUMAN KEBIRI KIMIA MENURUT PERATURAN PEMERINTAH NOMOR 70 TAHUN 2020
Authors: Mutiara Putri Dhita , Liany Lusy , Bunga Khoirunnisa Nadya , Meutia Rahmah Shafa 
Published: July 2022

Hukuman bagi pelaku kekerasan seksual sebagaimana tercantum dalam Undang-Undang Perlindungan Anak dianggap belum efektif sehingga Pemerintah menerbitkan Peraturan Pemerintah Nomor 70 Tahun 2020 yang menerapkan pelaksanaan dari kebiri kimia. Penelitian ini mengkaji peraturan pelaksana dari hukuman pidana tambahan kebiri kimia di Indonesia. Implementasi kasus penerapan kebiri kimia pertama kali di Indonesia pada Putusan Nomor 69/Pid.sus/2019/PN.Mjk tanggal 2 Mei 2019. Penerapan kebiri secara kimia menimbulkan pro kontra pada penerapan kebiri kimia terkait efektifitasnya dan pemberlakuannya yang dianggap melanggar hak asasi manusia sebagaimana termuat dalam UUD 1945 dan Undang-Undang Nomor 39 Tahun 1999 tentang HAM. Terdapat juga pihak yang setuju terhadap pemberlakuan hukuman tambahan kebiri kimia. Namun, terlepas dari adanya pro kontra tersebut, Pemerintah menerbitkan aturan mengenai pelaksanaan kebiri kimia yang dimuat dalam Peraturan Pemerintah Nomor 70 Tahun 2020. Aturan ini dapat diberlakukan secara efektif, efisien, dan tepat sasaran guna mengurangi peningkatan jumlah kekerasan seksual dan timbulnya kejahatan yang berulang.
Development, In-Vitro Characterization and In-Vivo Osteoinductive Efficacy of a Novel Biomimetically-Precipitated Nanocrystalline Calcium Phosphate With Internally-Incorporated Bone Morphogenetic Protein-2
Authors: Xu Gaoli , Shen Chenxi , Lin Haiyan , Zhou Jian , Wang Ting , Wan Ben , Binshabaib Munerah , Forouzanfar Tymour , Xu Guochao , Alharbi Nawal , Wu Gang 
Published: July 2022

The repair of large-volume bone defects (LVBDs) remains a great challenge in the fields of orthopedics and maxillofacial surgery. Most clinically available bone-defect-filling materials lack proper degradability and efficient osteoinductivity. In this study, we synthesized a novel biomimetically-precipitated nanocrystalline calcium phosphate (BpNcCaP) with internally incorporated bone morphogenetic protein-2 (BpNcCaP + BMP-2) with an aim to develop properly degradable and highly osteoinductive granules to repair LVBDs. We first characterized the physicochemical properties of the granules with different incorporation amounts of BMP-2 using scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. We evaluated the cytotoxicity and cytocompatibility of BpNcCaP by assessing the viability and adhesion of MC3T3-E1 pre-osteoblasts using PrestoBlue assay, Rhodamine-Phalloidin and DAPI staining, respectively. We further assessed the in-vivo osteoinductive efficacy in a subcutaneous bone induction model in rats. In-vitro characterization data showed that the BpNcCaP + BMP-2 granules were comprised of hexagonal hydroxyapatite with an average crystallite size ranging from 19.7 to 25.1 nm and a grain size at 84.13 ± 28.46 nm. The vickers hardness of BpNcCaP was 32.50 ± 3.58 HV 0.025. BpNcCaP showed no obvious cytotoxicity and was favorable for the adhesion of pre-osteoblasts. BMP-2 incorporation rate could be as high as 65.04 ± 6.01%. In-vivo histomorphometric analysis showed that the volume of new bone induced by BpNcCaP exhibited a BMP-2 amount-dependent increasing manner. The BpNcCaP+50 μg BMP-2 exhibited significantly more degradation and fewer foreign body giant cells in comparison with BpNcCaP. These data suggested a promising application potential of BpNcCaP + BMP-2 in repairing LVBDs.
Finite element analysis of different fixation methods of screws on absorbable plate for rib fractures
Authors: Xue Hang , Zhang Zhenhe , Liu Mengfei , Lin Ze , Endo Yori , Liu Guodong , Mi Bobin , Zhou Wu , Liu Guohui 
Published: July 2022

Multiple rib fractures caused by trauma are common injuries and the internal fixation methods of these injuries have been paid more and more attention by surgeons. Absorbable plates and screws are the effective way to treat rib fractures, but there are no reports on which type of screw fixation method is most effective. In this study, finite element analysis was used to study the effects of five different types of screw fixation methods on anterior rib, lateral rib and posterior rib. The finite element model of the ribs was reconstructed from CT images, and the internal pressure (40 kPa) and intercostal force (30 N) on the surfaces of the ribs were simulated accordingly. An intercostal force of 30 N was applied to the upper and lower surfaces of the ribs to simulate the effect of intercostal muscle force. The pressure of 40 kPa was applied to the inner surface of the ribs, and the normal direction was applied to the inner surface of the ribs. The positive direction was considered inspiratory pressure, and the negative direction was considered expiratory pressure. The results indicate the optimal type of screw fixation on the absorbable plate for rib fractures, and provide a basis and reference for clinical application.
Recent Advances in Cartesian-Grid DFT in Atoms and Molecules
Authors: Majumdar Sangita , Roy Amlan K. 
Published: July 2022

In the past several decades, density functional theory (DFT) has evolved as a leading player across a dazzling variety of fields, from organic chemistry to condensed matter physics. The simple conceptual framework and computational elegance are the underlying driver for this. This article reviews some of the recent developments that have taken place in our laboratory in the past 5 years. Efforts are made to validate a viable alternative for DFT calculations for small to medium systems through a Cartesian coordinate grid- (CCG-) based pseudopotential Kohn–Sham (KS) DFT framework using LCAO-MO ansatz. In order to legitimize its suitability and efficacy, at first, electric response properties, such as dipole moment (μ), static dipole polarizability (α), and first hyperpolarizability (β), are calculated. Next, we present a purely numerical approach in CCG for proficient computation of exact exchange density contribution in certain types of orbital-dependent density functionals. A Fourier convolution theorem combined with a range-separated Coulomb interaction kernel is invoked. This takes motivation from a semi-numerical algorithm, where the rate-deciding factor is the evaluation of electrostatic potential. Its success further leads to a systematic self-consistent approach from first principles, which is desirable in the development of optimally tuned range-separated hybrid and hyper functionals. Next, we discuss a simple, alternative time-independent DFT procedure, for computation of single-particle excitation energies, by means of “adiabatic connection theorem” and virial theorem. Optical gaps in organic chromophores, dyes, linear/non-linear PAHs, and charge transfer complexes are faithfully reproduced. In short, CCG-DFT is shown to be a successful route for various practical applications in electronic systems.
Design, Synthesis, and Biological Activity of Novel Chalcone Derivatives Containing an 1,2,4-Oxadiazole Moiety
Authors: Luo Ling , Liu Dan , Lan Shichao , Gan Xiuhai 
Published: July 2022

To discover a lead compound for agricultural use, 34 novel chalcone derivatives containing an 1,2,4-oxadiazole moiety were designed and synthesized. Their nematocidal activities against Bursaphelenchus xylophilus, Aphelenchoides besseyi, and Ditylenchus dipsaci and their antiviral activities against tobacco mosaic virus (TMV), pepper mild mottle virus (PMMoV), and tomato spotted wilt virus (TSWV) were evaluated. Biological assay results indicate that compounds A13 and A14 showed good nematocidal activities against B. xylophilus, A. besseyi, and D. dipsaci, with LC50 values of 35.5, 44.7, and 30.2 μg/ml and 31.8, 47.4, and 36.5 μg/ml, respectively, which are better than tioxazafen, fosthiazate, and abamectin. Furthermore, compound A16 demonstrated excellent protective activity against TMV, PMMoV, and TSWV, with EC50 values of 210.4, 156.2, and 178.2 μg/ml, respectively, which are superior to ningnanmycin (242.6, 218.4, and 180.5 μg/ml).
A nomogram for reduced cardiac function in postoperative acute type A aortic dissection patients with acute kidney injury undergoing continuous renal replacement therapy
Authors: Jiao Rui , Liu Maomao , Lu Xuran , Zhu Junming , Sun Lizhong , Liu Nan 
Published: July 2022

BackgroundThis study aimed to develop a nomogram to predict reduced cardiac function for acute kidney injury (AKI) patients who received continuous renal replacement therapy (CRRT) after acute type A aortic dissection (ATAAD) surgery.MethodsThis study was a retrospective analysis. ATAAD patients with preoperative normal ejection fraction (EF) and postoperative AKI with CRRT admitted between January 2014 and November 2021 were included. The reduced cardiac function was defined as EF &lt;50%. The data were analyzed by the univariate and multivariate logistic regression analyses. A diagnostic model was established by a nomogram, and its discriminative performance was validated by the received operating characteristic (ROC) curve and concordance (C) statistic. The calibration of the diagnostic model was tested by calibration curves and the HosmerLemeshow test. The clinical utility was evaluated by the decision curve analysis (DCA).ResultIn total, 208 patients were eligible for analysis, of which 98 patients with reduced cardiac function. The logistic regression analyses showed age ≥60 years old, history of coronary atherosclerotic disease, preoperative pericardial tamponade, and cardiopulmonary bypass time were risk factors for reduced cardiac function, which were further employed in the nomogram. As results, nomogram revealed a high predictive power (C statistic = 0.723, 0.654–0.792; the bootstrap-corrected concordance C statistic = 0.711, the area under the ROC curve = 0.723). The calibration curves showed good consistency between the predicted and the actual probabilities (calibration curve: Brier points = 0.208, Emax = 0.103, Eavg = 0.021; Hosmer-Lemeshow test, P = 0.476). DCA showed that the nomogram could augment net benefits and exhibited a wide range of threshold probabilities in the prediction of EF reduction.ConclusionThis nomogram is an effective diagnostic model for predicting the reduced cardiac function in postoperative ATAAD patients with AKI undergoing CRRT and can be used to protect postoperative renal functions and facilitate patient-specific care after ATAAD surgery.
Urinary matrix Gla protein is associated with mortality risk in Flemish population: A prospective study
Authors: Wei Dongmei , Melgarejo Jesus , Vanassche Thomas , Van Aelst Lucas , Janssens Stefan , Verhamme Peter , Zhang Zhen-Yu 
Published: July 2022

BackgroundVascular calcification is strongly related to the risk of mortality and cardiovascular (CV) diseases. In vascular calcification, matrix Gla protein (MGP), a small vitamin K-dependent protein, is an important mineralization inhibitor. Recent studies showed that circulating MGP is associated with mortality risk. However, the longitudinal association between urinary excretion of MGP and all-cause mortality was not established.Materials and methodsUrinary MGP was measured in 776 randomly recruited Flemish population (mean age: 51.2 years; 50.9% women) at baseline (during 2005–2010) using capillary electrophoresis coupled with mass spectrometry. Plasma inactive MGP [desphospho-uncarboxylated MGP (dp-ucMGP)] levels were quantified in 646 individuals by ELISA kits. Mortality status was ascertained through the Belgian Population Registry until 2016. The longitudinal association with mortality was determined by the multivariate-adjusted Cox proportional hazards regression models. The multivariate linear regression models were used to identify determinants of urinary MGP level.ResultsOver the 9.2 years, 47 (6.06%) participants died, including 15 CV deaths. For a doubling of urinary MGP, the hazard ratios (HRs) were 1.31 (95% CI: 1.01–1.69, P = 0.040) for all-cause mortality and 2.05 (95% CI: 1.11–3.79, P = 0.023) for CV mortality with adjustment for covariates, including estimated glomerular filtration rate and urine microalbumin. The addition of urinary MGP to the basic models improved the reclassification as suggested by the increased net reclassification improvement [64.01% (95% CI: 32.64–98.63)] and integrated discrimination improvement [2.33% (95% CI: 0.24–4.71)]. Circulating inactive MGP, total cholesterol, urine microalbumin, and smoking were significantly associated with urinary MGP levels (P ≤ 0.041), independent of sex and age.ConclusionElevated urinary MGP was associated with an increased risk of all-cause mortality and CV mortality and improved the risk reclassification for all-cause mortality. These findings suggested that urinary MGP might be useful in mortality risk assessment in the general population. However, these observations need to be replicated in larger studies with a longer follow-up time.