bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of the Compliance Level of Antihypertensive Drug Use in First and Advanced Level Health Facilities
Authors: Rizal Rizal  
Published: November 2022

The adherence with therapy in hypertensive patients is important to note because hypertension is a disease that cannot be cured but can only be controlled. The success of controlling blood pressure in hypertensive patients influenced by compliance factors in taking antihypertensive drugs. The purpose of this study is to evaluate the relationship between the level of adherence of antihypertensive drugsuse in first and advanced health facilities.
The study design was an observational cross sectional using subjects with hypertension patients older than or equal to 18 years old at Kotabunan Bolaang Mongondow Health Center (first level health facility) and outpatient installation of Robert Wolter Monginsidi Hospital in Manado (advanced health facilities) during the period from October to December 2019. The level of compliance with the use of antihypertensive drugs was assessed using the MMAS-8 questionnaire (Morisky 8-Item Medication Adherence Scale).
The total patients in this study were 171 patients, as many as 73 patients in the first level health facilities and 98 patients in the advanced health facilities. The data of patient adherence in the use of antihypertensive drugs in the first level of health facilities showed 83.56% with low levels of adherence (MMAS score <6), and only 16.44% with moderate to high levels of adherence (MMAS score 6-8). In the advanced level of health facilities were 85.71% of patients with low adherence and 14.29% with moderate to high adherence. Comparative statistical of adherence on the two health facilities was not significantly different, with p = 0.767 (95% confidence interval). The data shows that the average patient has a routine history of control as much as 91.8% in health facilities.
Based on these results, recommended that each hospital and health center must require its pharmacists to do pharmaceutical practices, and each pharmacy must not provide drug services without the presence of a pharmacist.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN STUNTING PADA BALITA 24-60 BULAN DI WILAYAH PUSKESMAS OLLOT KABUPATEN BOLAANG MONGONDOW UTARA TAHUN 2019
Authors: Nelawati Radjamuda  , Ike Fitrah  , Agust Laya  
Published: November 2022

Gizi buruk menyebabkan terhambatnya pertumbuhan pada anak-anak. Salah satu masalah pertumbuhan pada balita adalah terhambatnya pertumbuhan tinggi badan anak sehingga anak tumbuh tinggi tidak sesuai dengan umurnya yang disebut dengan balita pendek atau stunting. Penelitian ini bertujuan mengetahui gambaran dan factor-faktor yang berhubungan dengan kejadian stunting pada balita umur 24-59 bulan di wilayah kerja Puskesmas Ollot tahun 2019.
Desain pada penelitian ini menggunakan cross sectional dengan penelitian survey analitik. Sampel yang sebanyak 91 responden. Analisis yang digunakan chi-square untuk melihat hubungan antar variabel.
Hasil penelitian ini sebanyak 13% balita usia 24-59 bulan di Puskesmas Ollot yang berat lahirnya <2500gram BBLR, 75% berstatus infeksi penyakit (diare dan ISPA), 65% tidak mendapatkan ASI Eksklusif, dan 91% balita memiliki status imunisasi dasar lengkap. Dililihat dari hasil analisis terdapat hubungan beramakna antara faktor pemberian ASI Eksklusif dengan kejadian stunting pada balita usia 24-59 bulan di Puskesmas Ollot Tahun 2019. Diharapkan Dinas Kesehatan bersama Pemerintah Kabupaten untuk dapat memberikan informasi secara luas melalui penyuluhan maupun pelatihan kepada masyarakat ataupun kader kesehatan mengenai status gizi balita khusunya stunting.
UJI AKTIVITAS ANTIBAKTERI DARI EKSTRAK ETANOL DAUN KAYU KAMBING (Garuga Floribunda, Decne) PADA BAKTERI Eschericia coli dan Staphylococcus aureus
Authors: Hamidah Sri Supriati  , Abulkhair Abdullah  , Muhammad Hidayat  
Published: November 2022

Tanaman Kayu Kambing Garuga floribunda,Decne merupakan tanaman yang banyak terdapat di wilayah Sulawesi Utara yang belum banyak diteliti. Penelusuran metabolit sekunder daun tanaman kayu kambing menggunakan metode maserasi dengan etanol 70% . Kemudian dipartisi dengan menggunakan n-heksan. Ekstrak yang diperoleh pada fase etanol dan n-heksan kemudian diuji metabolit sekunder dan antibakterinya dengan menggunakan bakteri Eschericia coli dan Staphylococcus aureus. Metabolit sekunder fase etanol diperoleh hasil positif pada senyawa metabolit sekunder Alkaloid, Saponin, Flavonoid, Steroid dan Tanin sedangkan fase n-heksan hasil positif pada Alkaloid dan Steroid. Aktivitas antibakteri pada E.coli memberikan zona hambat rata-rata 8,7 mm, pada Staphylococcus aureus zona hambat terbesar rata-rata 10,2 mm.
Hubungan Tingkat Kepatuhan Penggunaan Obat Antihipertensi pada Fasilitas Kesehatan Tingkat Pertama dan Lanjutan
Authors: Rizal Rizal  
Published: November 2022

ABSTRAK
Kepatuhan terapi pada pasin hipertensi merupakan hal yang penting untuk diperhatikan karena hipertensi merupakan penyakit yang tidak dapat disembuhkan tetapi hanya dapat dikendalikan. Keberhasilan pengontrolan tekanan darah pada pasien hipertensi dipengaruhi oleh faktor kepatuhan dalam meminum obat antihipertensi. Tujuan penelitian ini yaitu untuk mengevaluasi hubungan tingkat kepatuhan penggunaan obat antihipertensi pada fasilitas kesehatan tingkat pertama dan lanjutan.
Desain penelitian yaitu observasional cross sectional menggunakan subjek pasien hipertensi yang berusia lebih atau sama dengan 18 tahun di Puskesmas Kotabunan Bolaang Mongondow (fasilitas kesehatan tingkat pertama) dan instalasi rawat jalan Rumah Sakit Robert Wolter Monginsidi Manado (fasilitas kesehatan tingkat lanjutan) selama periode bulan Oktober hingga Desember 2019. Tingkat kepatuhan penggunaan obat antihipertensi dinilai dengan menggunakan kuesioner MMAS-8 (Morisky 8-Item Medication Adherence Scale).
Total pasien pada penelitian ini yaitu 171 pasien, sebanyak 73 pasien pada faskes (fasilitas kesehatan) tingkat pertama dan 98 pasien pada faskes lanjutan. Data tingkat kepatuhan pasien dalam penggunaan obat antihipertensi pada faskes tingkat pertama menunjukkan 83,56% dengan tingkat kepatuhan rendah (skor MMAS < 6), dan hanya 16,44% dengan tingkat kepatuhan sedang sampai tinggi (skor MMAS 6 – 8). Pada faskes tingkat lanjutan terdapat 85,71% pasien dengan tingkat kepatuhan rendah dan 14,29% dengan tingkat kepatuhan sedang sampai tinggi. Perbandingan statistik komparatif tingkat kepatuhan pada kedua faskes tersebut tidak berbeda signifikan dengan nilai p=0,767 (confidence interval 95%). Pada data menunjukkan bahwa rata-rata pasien memiliki riwayat rutin untuk kontrol sebanyak 91,8% pada fasilitas kesehatan.
Berdasarkan hasil tersebut maka disarankan agar setiap Rumah Sakit dan Puskesmas mewajibkan apotekernya untuk melakukan praktik kefarmasian, dan setiap apotek tidak boleh memberikan pelayanan obat tanpa kehadiran apoteker.
PENINGKATAN PENGETAHUAN MELALUI PEMERIKSAAN TEKANAN DARAH, KONSELING DAN PEMBENTUKAN KADER HIPERTENSI DI DESA KAUDITAN I KECAMATAN KAUDITAN MINAHASA UTARA
Authors: Bertina Hermin Korah  , Petronela Mamentu  
Published: November 2022

Hipertensi adalah keadaan di mana tekanan darah mengalami peningkatan yang memberikan gejala berlanjut pada suatu organ target di tubuh. Hal ini dapat menimbulkan kerusakan yang lebih berat, misalnya stroke (terjadi pada otak dan menyebabkan kematian yang cukup tinggi), penyakit jantung koroner (terjadi kerusakan pembuluh darah jantung), dan hipertrofi ventrikel kiri (terjadi pada otot jantung). Hipertensi juga dapat menyebabkan penyakit gagal ginjal, penyakit pembuluh darah dan penyakit lainnya.

Analisa situasi Hipertensi merupakan masalah kesehatan global yang membutuhkan perhatian karena dapat menyebabkan kematian utama di negara-negara maju maupun negara berkembang. Berdasarkan hasil survey tanggal 16 sampai 18 Februari di Desa Kauditan I Kabupaten Minahasa Utara, dengan populasi 855 KK, sampel 212 KK didapatkan data bahwa yang menderita menderita hipertensi ada 167 jiwa dan yang minum obat hipertensi secara teratur hanya 48 jiwa, artinya lebih dari 50% atau sekitar 119 jiwa yang tidak minum obat hipertensi dengan teratur.

Melalui kegiatan pengabdian masyarakat “Peningkatan pengetahuan melalui pemeriksaan tekanan darah, konseling, dan pembentukan kader hipertensi di desa Kauditan I Minahasa Utara yang dilaksanakan pada tanggal 03 Maret 2020 bertempat di kantor lurah desa Kauditan I didapatkan hasil evaluasi kader yang sudah dilatih dapat melakukan pengukuran tekanan darah dengan BAIK
“PENYEGARAN KADER DAN PELAYANAN POSYANDU LIMA MEJA DI PUSKESMAS PANIKI BAWAH KECAMATAN MAPANGET KOTA MANADO”
Authors: Ike Fitrah Atul Chabibah  , Berthina Hermien Korah  
Published: November 2022

Ada banyak faktor yang mempengaruhi tingkat AKB, tidak mudah untuk menemukan faktor yang paling dominan. Tersedianya berbagai fasilitas atau faktor aksesibilitas dan pelayanan kesehatan dari tenaga medis yang terampil, serta kesediaan masyarakat untuk merubah kehidupan tradisional ke norma kehidupan modern dalam bidang kesehatan merupakan faktor yang sangat berpengaruh terhadap tingkat AKB. Berdasarkan hasil survei Pendahuluan oleh Tim pengabdian masyarakat pada tanggal 4 Agustus 2019, di Puskesmas Paniki Bawah didapatkan hasil bahwa cakupan SKDN masih belum mencapai target nasional yaitu kurang dari 80 %. Sehingga perlu adanya upaya peningkatan capaian SKDN dengan salah satu cara yaitu pelatihan dan penyegaran Kader Posyandu di Wilayah kerja Puskesmas Paniki Bawah Kota Manado.
Metode pelaksanaan kegiatan Penyegaran kader posyandu tentang lima meja adalah dengan metode ceramah yang kemudian diimplementasikan dalam kegiatan pelayanan Posyandu Lima meja dengan sasaran Balita se kecamatan Mapanget. Kegiatan Pengabdian Masyarakat dilaksanakan selama 3 hari yaitu tanggal 5-7 November 2019. Hari ke 1 : Pembukaan, pretest, materi 5 meja dilanjutkan hari ke 2 : Post test dan penutupan. hari ke 3 : Pelayanan Posyandu Se Kecamatan Mapanget.
Hasil kegiatan Pengabdian Masyarakat ini yaitu Kader Mampu mengaplikasikan peran dan fungsinya sebagai kader posyandu, Meningkatkan kemampuan fasilitasi pembelajaran kader posyandu dalam melaksanakan tugas Penggerakan dan Pemberdayaan masyarakat, Meningkatkan keterampilan bagi kader Posyandu dalam menunjang pelaksanaan desa siaga, Meningkatkan keterampilan kader posyandu dalam melakukan komunikasi, advokasi dan negosiasi dengan pihak pemangku kepentingan di tingkat kecamatan dan desa dalam rangka mendapatkan dukungan sumber daya.
Pengembangan Potensi Mahasiswa Menjadi Investor Muda di Masa Depan
Authors: Umpu Singa Hasrun Afandi 
Published: November 2022

Abstract
According to Bruce Lliyd, the capital market acts as a liaison between investors and companies and government agencies through trading long-term instruments such as bonds, stocks, etc. Students as agents of change and the driving force of technological industry progress must have broad insights into financial management, and control that also pays attention to the potential for income in the form of investment. This activity aims to provide knowledge about the capital market and how to manage investments properly and correctly, to students of the Sharia Banking Department, Faculty of Economics and Islamic Business. So it is hoped that with the implementation of this seminar, students will be able to understand the capital market and how to manage investments, and can implement them in their lives in the future.
Keywords: Potential Development, Young Investors, Future
Peningkatan Produksi Kerajinan Anyaman Daun Lontar Sebagai Nilai Tambah Ekonomi di Desa Lapeom Kecamatan Insana Barat Kabupaten Timor Tengah Utara
Authors: Emilia Khristina Kiha  , Ernestina Lika  
Published: November 2022

Abstrak
Daun lontar yang sudah dikeringkan menghasilkan komoditi yang prospektif karena bahan merupakan bahan yang mudah untuk daur ulang dan digemari oleh pemesan. Dalam program pengabdian ini melibatkan pengerajin anyaman yang berskala IRT/UMKM dilihat dari kuantitas produk yang dihasilkan masih kecil, belum variatif dan dijual hanya sesuai pesanan, beralamat di Desa Lapeom, Kecamatan Insana Barat, Kabupaten Timor Tengah Utara. Pengrajin menghasilan produk anyaman seperti Tenasak, Nampan dan Koba serta beberapa produk sesuai pesanan. Solusi dan metode dari kegiatan pengabdian ini adalah memberikan pelatihan ketrampilan kepada ibu-ibu pengrajin anyaman daun lontar agar nantinya mampu menghasilkan produk unggulan yang memiliki nilai ekonomis serta dibutuhkan oleh pasar. Untuk menghasilkan produk yang memiliki nilai jual, pelatihan ketrampilan diarahkan pada kualitas produk anyaman daun lontar. Karena itu pelatihan yang diberikan juga akan mencakup teknis produksi, desain produk, serta Pemasaran berbasis Internet of Things (IoT) yang sangat sesuai dengan promosi produk di situasi Pandemi Covid 19.
Urogenital infection in preeclampsia
Authors: Hsu C.D. , Witter F.R. 
Published: July 2002

AbstractObjective: The purpose of this study was to determine whether the incidence of urinary tract infections and postpartum endometritis were increased in preeclamptic pregnancies. Method: We conducted a retrospective study of 13 852 pregnant women, using a perinatal database at The Johns Hopkins Hospital, over the past 5 years. The incidence of urinary tract infections and postpartum endometritis was analyzed using the chi‐squared test and logistic regression analysis. Statistical significance was set at P < 0.05. Results: There were 345 (2.5%) mild preeclamptics and 440 (3.2%) severe preeclamptics. The incidence of urinary tract infections and postpartum endometritis in preeclamptic patients was significantly higher than that in non‐hypertensive pregnant patients. After controlling for confounding variables, severe preeclampsia was still found to be an independent significant risk factor for both urinary tract infections and postpartum endometritis. Conclusion: Our data show a significant increase in urogenital infection in preeclamptic pregnancy. This may reflect higher rates of underlying renal disease and placental bed abnormalities occurring in preeclampsia.
Neurobehavioral aspects of antioxidants in aging
Authors: Cantuti‐Castelvetri Ippolita , Shukitt‐Hale Barbara , Joseph James A. 
Published: July 2002

AbstractBoth aging and age‐associated neurodegenerative diseases are associated with various degrees of behavioral impairments, and among the prime candidates responsible for producing the neuronal changes mediating these behavioral deficits appear to be free radicals and the oxidative stress they generate. Therefore, there have been a number of studies which have examined the putative positive benefits of antioxidants in altering, reversing, or forestalling these neuronal/behavioral decrements, with varying degrees of success. Additional experiments have examined the effects of diets rich in fruits and vegetables or herbal extracts in reducing certain types of cancer and cardiovascular diseases, and evidence emerging from such experiments suggests that these kinds of dietary modifications may be beneficial in altering neuronal/behavioral deficits in aging, as well. These kinds of diets are particularly rich in antioxidants such as vitamins A, C, E, and bioflavonoids (such as flavones, tannins, and anthocyanins), and thus, there may be synergistic effects among them. The present paper will review studies concerning the influence of dietary and synthetic antioxidants on normal, pathological age‐related, and reactive oxygen species‐induced behavioral changes in human and animal subjects. The antioxidants reviewed are vitamin E, α‐lipoic acid, and the phytochemicals contained in herbals, fruits and vegetables.
Induction of tissue plasminogen activator in differentiated NG108‐15 cells
Authors: Friedman Glenn C. , Seeds Nicholas W. 
Published: July 2002

AbstractPlasminogen activators may facilitate neurite outgrowth and neuronal migration in the developing nervous system. The expression of tissue plasminogen activator by NG108‐15 neuroblastoma grown under a variety of conditions has been explored. High tissue plasminogen mRNA expression correlates with growth conditions which induce morphological differentiation and neurite outgrowth; however, NG108‐15 cells grown in suspension with dibutyryl‐cAMP also show a high level of tissue plasminogen activator expression.
Intradermal spindle cell/pleomorphic lipoma of the vulva: case report and review of the literature
Authors: Reis‐Filho Jorge S. , Milanezi Fernanda , Soares Maria F. , Fillus‐Neto José , Schmitt Fernando C. 
Published: July 2002

Background: Spindle cell/pleomorphic lipoma (SC/PL) is a benign adipose tissue tumor that usually affects the subcutaneous tissues of shoulders, backs, and neck region of middle‐aged male patients. Histologically, it is characterized by the presence of primitive CD34‐positive spindle cells arranged in short fascicles, bizarre floret‐like multinucleated giant cells, mature adipocytes, and a small number of lipoblasts. Recently, an intradermal subset has been described, which mainly affects female patients and presents a wider antomical distribution when compared to the classical variant of SC/PL.Methods: We report a case of intradermal SC/PL affecting the labium majus of a 56‐year‐old female patient.Results: The histological examination disclosed the typical histological features, however the lesion showed poorly demarcated and infiltrative borders, as well as involvement of dermal nerves. The immunohistochemical analysis according to streptovidin‐biotin‐peroxidase technique showed immunoreactivity for CD34 and vimentin in the spindle cells, as well as S100 protein and vimentin in the adipocytic cells.Conclusions: To the best of our knowledge, this is the first case of intradermal SC/PL affecting the vulvar region. Care must be taken not to misdiagnosis this rare tumor as well‐differentiated liposarcoma, cellular angiofibroma, solitary fibrous tumor, and cutaneous neurofibroma.
Insulin‐like growth factor I administration induces fluid and sodium retention in healthy adults: possible involvement of renin and atrial natriuretic factor
Authors: Møller Jens , Jørgensen Jens O. L. , Marqversen Jørgen , Frandsen Erik , Christiansen Jens S. 
Published: July 2002

OBJECTIVEGrowth hormone induces fluid and sodium retention. The underlying mechanism is, however, incompletely understood. A possible mediator could be IGF‐I. To investigate the impact of IGF‐I administration on body fluid distribution and sodium homeostasis in healthy subjects, we examined normal subjects during six days IGF‐I treatment and during a six‐day control period.DESIGN AND MEASUREMENTSEight normal male subjects aged 23–30 years were randomised to receive IGF‐I 50 μg/kg subcutaneously thrice daily during a six day study period, and to a six day control period. After each study period, extracellular volume and plasma volume (ECV, PV) were determined using 82Br and 125I‐albumin. Blood samples, urinary sodium excretion, and bioimpedance were measured every second day of each study period.RESULTSSerum IGF‐I (μg/l) increased during active treatment (control, 293 ± 9; IGF‐I, 628 ± 42; P < 0.01). ECV (l) was expanded by IGF‐I (control, 18.42 ± 0.28; IGF‐I, 19.72 ± 0.50; P < 0.05) whereas PV (l) remained unaffected (control, 3.76 ± 0.11; IGF‐I, 3.80 ± 0.16; n.s.). Likewise, bioimpedance and body weight were unchanged by IGF‐I. Plasma renin (mU/l) increased but not significantly during IGF‐I (control, 28.7 ± 2.7; IGF‐I, 39.9 ± 4.3; P = 0.08), and plasma aldosterone was unaffected by IGF‐I. N‐Terminal proANF (pmol/l) was suppressed during IGF‐I administration (control, 422 ± 32; IGF‐I, 330 ± 20; P < 0.05). Diurnal sodium excretion (mmol) was reduced during IGF‐I administration (control, 151 ± 8; IGF‐I, 124 ± 7; P < 0.05).CONCLUSIONIGF‐I treatment causes fluid and sodium retention. This may be mediated by increased renin release and suppression of atrial natriuretic factor. The present data suggest that the fluid and sodium retaining effect of GH is at least partly mediated through IGF‐I.
GANGRENOUS CHOLECYSTITIS IN THE LAPAROSCOPIC ERA
Authors: Hunt D. R. H. , Chu F. C. K. 
Published: July 2002

Background: We reviewed our data of laparoscopic cholecystectomies between 1990 and 1997 with reference to gangrenous cholecystitis. Methods: In a consecutive series of 1304 patients having laparoscopic cholecystectomies, prospective data collection has permitted analysis of the relationship between gangrenous cholecystitis (GC), acute (non‐gangrenous) cholecystitis (AC) and non‐acute cholecystectomies (NAC). Results: Twenty‐five patients had gangrenous cholecystitis and 238 had acute cholecystitis. We found that patients with GC were significantly older (65.4 years vs 56.1 years (AC) and 52.7 years (NAC), P < 0.05) and had a higher M : F ratio (1.5:1 vs 1:2.6 (AC) and 1:2.8 (NAC), P < 0.05). Cardiac disease was found to be a significant factor but not diabetes. Preoperative ultrasonography correctly identified only 17 patients with acute inflammatory changes. Seven patients had an absent sonographic Murphy’s sign. The gall bladder wall was generally thicker (4.11 mm vs 3.8 mm (AC) and 2.7 mm (NAC), P < 0.05) but there was marked overlap between the three groups. The common bile duct (CBD) was more dilated (6.1 mm vs 4.8 mm (AC) and 4.6 mm (NAC), P < 0.006) and there was increased incidence of CBD stones in the GC group. Our conversion rate was 8.7% with minimal complications and no operative mortality. Conclusion: Patients with GC were generally older, more likely to be male and had increased incidence of cardiovascular disease. Preoperative ultrasound cannot accurately identify those patients with gangrenous cholecystitis, but with conversion rates of 8.7% and no operative mortality, they can generally be managed safely with laparoscopic surgical techniques.
A preliminary investigation into the aetiology of Meares–Irlen syndrome
Authors: Evans B. J. W. , Wilkins A. J. , Brown J. , Busby A. , Wingfield A. , Jeanes R. , Bald J. 
Published: July 2002

SummaryA recent double‐masked placebo‐controlled trial has confirmed that some children experience a reduction in symptoms of eyestrain and headache when they read through individually prescribed coloured filters and has shown that this benefit cannot be solely attributed to a placebo effect. People who are helped by coloured filters in this way have been described as having ‘Meares–Irlen syndrome’. We investigated the mechanism of this benefit by studying the optometric and visual perceptual characteristics of the children in the double‐masked study. This population had normal refractive errors and heterophorias (none of the subjects had strabismus). They demonstrated slightly, but significantly, reduced amplitudes of accommodation and vergence and poor stereo‐acuity. However, these factors seemed to be correlates of Meares‐Irlen syndrome rather than the underlying cause. Pattern glare, a sensitivity to striped patterns (e.g. lines of text), was prevalent in our sample and was significantly associated with the subjects' symptoms. The spatial contrast sensitivity function was normal.