bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient-reported outcome measures, complication rates, and re-revision rates are not associated with the indication for revision total hip arthroplasty
Authors: Innocenti Matteo , Smulders Katrijn , Willems Jore H. , Goosen Jon H. M. , van Hellemondt Gijs 
Published: July 2022

Aims The aim of this study was to explore the relationship between reason for revision total hip arthroplasty (rTHA) and outcomes in terms of patient-reported outcome measures (PROMs). Methods We reviewed a prospective cohort of 647 patients undergoing full or partial rTHA at a single high-volume centre with a minimum of two years’ follow-up. The reasons for revision were classified as: infection; aseptic loosening; dislocation; structural failure; and painful THA for other reasons. PROMs (modified Oxford Hip Score (mOHS), EuroQol five-dimension three-level health questionnaire (EQ-5D-3L) score, and visual analogue scales for pain during rest and activity), complication rates, and failure rates were compared among the groups. Results The indication for revision influenced PROMs improvement over time. This finding mainly reflected preoperative differences between the groups, but diminished between the first and second postoperative years. Preoperatively, patients revised due to infection and aseptic loosening had a lower mOHS than patients with other indications for revision. Pain scores at baseline were highest in patients being revised for dislocation. Infection and aseptic loosening groups showed marked changes over time in both mOHS and EQ-5D-3L. Overall complications and re-revision rates were 35.4% and 9.7% respectively, with no differences between the groups (p = 0.351 and p = 0.470, respectively). Conclusion Good outcomes were generally obtained regardless of the reason for revision, with patients having the poorest preoperative scores exhibiting the greatest improvement in PROMs. Furthermore, overall complication and reoperation rates were in line with previous reports and did not differ between different indications for rTHA. Cite this article: Bone Joint J 2022;104-B(7):859–866.
July 2022 Sleep Case of the Month: A Sleepy Scout
Authors:   Honolulu, HI USA, Fukui Christine 
Published: July 2022

No abstract available. Article truncated after 150 words. History of Present Illness: A 25-year-old African American man complaining of excessive daytime somnolence. He was a US Army Ranger scout who received a traumatic brain injury (TBI) from an improvised explosive device attack in Afghanistan which resulted in a loss of about ¼ of his visual field. He said he slept well at night and there was no history of snoring. There was no history of any parasomnias. PMH, SH, FH: Other than the traumatic brain injury there was no significant PMH. His most recent brain scan showed only the remnants of his brain injury which resulted in an intracerebral hemorrhage which was managed conservatively. He was single. He did not smoke and had only moderate alcohol intake. There was no significant FH of sleep apnea. Physical Examination: Other than the visual field loss his physical examination was unremarkable. What should be done next? 1.	Brain MRI 2.	Electroencephalogram …
The indirect impact of COVID-19 pandemic on the utilization of the emergency medical services during the first pandemic wave: A system-wide study of Tuscany Region, Italy
Authors: Lastrucci Vieri , Collini Francesca , Forni Silvia , D’Arienzo Sara , Di Fabrizio Valeria , Buscemi Primo , Lorini Chiara , Gemmi Fabrizio , Bonaccorsi Guglielmo 
Published: July 2022

Background
Utilization of Emergency Medical Services (EMS) declined during COVID-19 pandemic, but most of the studies analyzed components of the EMS system individually. The study aimed to evaluate the indirect impact of COVID-19 pandemic on the utilization of all the components of the EMS system of Tuscany Region (Italy) during the first pandemic wave.

Methods
Administrative data from the health care system of Tuscany were used. Changes in utilization for out-of-hospital emergency calls and emergency vehicle dispatched, emergency department (ED) visits, and patients being admitted from the ED to an inpatient hospital bed (hospitalizations from ED) during the first pandemic wave were analyzed in relation with corresponding periods of the previous two years. Percentage changes and 95%CI were calculated with Poisson models. Standardized Ratios were calculated to evaluate changes in in-hospital mortality and hospitalizations requiring ICU.

Results
Significant declines were observed in the utilization of all the EMS considered starting from the week in which the first case of COVID-19 was diagnosed in Italy till the end of the first pandemic wave. During the epidemic peak, the maximum decreases were observed: -33% for the emergency calls, -45% for the dispatch of emergency vehicles, -71% for ED admissions. Furthermore, a decline of 37% for hospitalizations from ED was recorded. Significant decreases in ED admissions for life threatening medical conditions were observed: acute cerebrovascular disease (-36%, 95% CI: -43, -29), acute myocardial infarction (-42%, 95% CI: -52, -31) and renal failure (-42%, 95% CI: -52, -31). No significant differences were found between the observed and the expected in-hospital mortality and hospitalizations requiring ICU during the epidemic peak.

Conclusion
All the components of the EMS showed large declines in their utilization during COVID-19 pandemic; furthermore, major reductions were observed for admissions for time-dependent and life-threatening conditions. Efforts should be made to ensure access to safe and high-quality emergency care during pandemic.
Efficacy and safety of saroglitazar for the management of dyslipidemia: A systematic review and meta-analysis of interventional studies
Authors: Chhabra Manik , Vidyasagar Kota , Gudi Sai Krishna , Sharma Jatin , Sharma Rishabh , Rashid Muhammed 
Published: July 2022

Background and objective
Saroglitazar is a newer antidiabetic agent approved to manage dyslipidemia. The objective is tevaluate the efficacy and safety profiles of saroglitazar in patients with dyslipidemia.

Methods
A systematic search was conducted using PubMed, Cochrane Library, Scopus, and Google Scholar from the inception until January 2022. Interventional studies comparing the anti-hyperlipidaemic effect and safety of saroglitazar with or without a control group(s) were included. The efficacy of saroglitazar was assessed concerning its effect on total cholesterol, low density lipoprotein (LDL) and high density lipoprotein (HDL)-cholesterol, triglycerides, fasting plasma glucose, and non-HDL cholesterol. The effects on serum creatinine levels, bodyweight reduction, alanine aminotransferase and aspartate aminotransferase were considered to be safety endpoint.The Cochrane risk of bias assessment tool was used to assess the methodological quality of the included studies.

Results
A total of six studies with 581 adults with a mean age ranging from 40.2 to 62.6 years were included in this study. A significant decrease in low-density lipoprotein cholesterol was observed with saroglitazar 4 mg therapy compared to saroglitazar 2 mg [standardized mean difference (SMD): −0.23 mg/dL, 95% CI: −0.47 to 0.00; p  =  0.05; 2 studies], and control [SMD: −0.36 mg/dL, 95% CI −0.59 to -0.12; p  =  0.0026; 3 studies]. Also, a significant decrease in the total cholesterol was observed with saroglitazar 4 mg therapy compared to saroglitazar 2 mg [SMD − 0.28 mg/dL, 95% CI: − 0.52 to -0.04; p < 0.01; 2 studies], and control [SMD − 0.49 mg/dL, 95% CI: − 0.72 to -0.26; p < 0.0001; 3 studies]. Saroglitazar was not associated with adverse effects such as increase in serum creatinine levels, alanine aminotransferase and aspartate aminotransferase and bodyweight reduction.

Conclusion
Saroglitazar appeared to be an effective and safer therapeutic option for improving dyslipidemia in patients. However, comparative studies of saroglitazar with the other pharmacological agents are warranted.
Validation of the German version of the STarT-MSK-Tool: A cohort study with patients from physiotherapy clinics
Authors: Karstens Sven , Zebisch Jochen , Wey Johannes , Hilfiker Roger , Hill Jonathan C. 
Published: July 2022

Background
The STarT-MSK-Tool is an adaptation of the well established STarT-Back-Tool, used to risk-stratify patients with a wider range of musculoskeletal presentations.

Objective
To formally translate and cross-culturally adapt the Keele STarT-MSK risk stratification tool into German (STarT-MSKG) and to establish its reliability and validity.

Methods
A formal, multi-step, forward and backward translation approach was used. To assess validity patients aged ≥18 years, with acute, subacute or chronic musculoskeletal presentations in the lumbar spine, hip, knee, shoulder, or neck were included. The prospective cohort was used with initial data collected electronically at the point-of-consultation. Retest and 6-month follow-up questionnaires were sent by email. Test-retest reliability, construct validity, discriminative ability, predictive ability and floor or ceiling effects were analysed using intraclass correlation coefficient, and comparisons with a reference standard (Orebro-Musculoskeletal-Pain-Questionnaire: OMPQ) using correlations, ROC-curves and regression models.

Results
The participants’ (n = 287) mean age was 47 (SD = 15.8) years, 51% were female, with 48.8% at low, 43.6% at medium, and 7.7% at high risk. With ICC = 0.75 (95% CI 0.69; 0.81) test-retest-reliability was good. Construct validity was good with correlations for the STarT-MSKG-Tool against the OMPQ-Tool of rs = 0.74 (95% CI 0.68, 0.79). The ability of the tool [comparison OMPQ] to predict 6-month pain and disability was acceptable with AUC = 0.77 (95% CI 0.71, 0.83) [OMPQ = 0.74] and 0.76 (95% CI 0.69, 0.82) [OMPQ = 0.72] respectively. However, the explained variance (linear/logistic regression) for predicting 6-month pain (21% [OMPQ = 17%]/logistic = 29%) and disability (linear = 20%:[OMPQ = 19%]/logistic = 26%), whilst being comparable to the existing OMPQ reference standard, fell short of the a priori target of ≥30%.

Conclusions
The German version of the STarT-MSK-Tool is a valid instrument for use across multiple musculoskeletal conditions and is availabe for use in clinical practice. Comparison with the OMPQ suggests it is a good alternative.
Single-cell specific and interpretable machine learning models for sparse scChIP-seq data imputation
Authors: Albrecht Steffen , Andreani Tommaso , Andrade-Navarro Miguel A. , Fontaine Jean Fred 
Published: July 2022

MotivationSingle-cell Chromatin ImmunoPrecipitation DNA-Sequencing (scChIP-seq) analysis is challenging due to data sparsity. High degree of sparsity in biological high-throughput single-cell data is generally handled with imputation methods that complete the data, but specific methods for scChIP-seq are lacking. We present SIMPA, a scChIP-seq data imputation method leveraging predictive information within bulk data from the ENCODE project to impute missing protein-DNA interacting regions of target histone marks or transcription factors.ResultsImputations using machine learning models trained for each single cell, each ChIP protein target, and each genomic region accurately preserve cell type clustering and improve pathway-related gene identification on real human data. Results on bulk data simulating single cells show that the imputations are single-cell specific as the imputed profiles are closer to the simulated cell than to other cells related to the same ChIP protein target and the same cell type. Simulations also show that 100 input genomic regions are already enough to train single-cell specific models for the imputation of thousands of undetected regions. Furthermore, SIMPA enables the interpretation of machine learning models by revealing interaction sites of a given single cell that are most important for the imputation model trained for a specific genomic region. The corresponding feature importance values derived from promoter-interaction profiles of H3K4me3, an activating histone mark, highly correlate with co-expression of genes that are present within the cell-type specific pathways in 2 real human and mouse datasets. The SIMPA’s interpretable imputation method allows users to gain a deep understanding of individual cells and, consequently, of sparse scChIP-seq datasets.Availability and implementationOur interpretable imputation algorithm was implemented in Python and is available athttps://github.com/salbrec/SIMPA.
Performance of NUTRIC score to predict 28-day mortality in critically ill patients after replacing APACHE II with SAPS 3
Authors: Souza Ivens Augusto Oliveira , Ribeiro Paulo Cesar , Jonckheer Joop , De Waele Elisabeth , Taniguchi Leandro Utino 
Published: July 2022

Objectives
The Nutrition Risk in the Critically Ill (NUTRIC) score has been advocated as a screening tool for nutrition risk assessment in critically ill patients. It was developed and validated to predict 28-day mortality using Acute Physiology and Chronic Health Evaluation II (APACHE II) score as one of its components. However, nowadays the Simplified Acute Physiology Score 3 (SAPS 3) demonstrates better performance. We aimed to test the performance of NUTRIC score in predicting 28-day mortality after replacement of APACHE II by SAPS 3, and the interaction between nutrition adequacy and mortality.

Methods
Adult patients who received nutrition therapy and remained >3 days in intensive care unit were retrospectively evaluated. In order to replace APACHE II component, we used ranges of SAPS 3 with similar predicted mortality. Discrimination between these tools in predicting 28-day mortality was assessed using the ROC curve, calibration was evaluated with calibration belt, and correlation with intraclass correlation. The relationship between nutritional adequacy and mortality was assessed in a subgroup with available data.

Results
542 patients were analyzed (median age of 78 years old, 73.4% admitted for non-surgical reasons and 28-day mortality was 18.1%). Mortality prediction discrimination did not differ between tools (p>0.05), but showed a good agreement (intraclass correlation 0.86) with good calibration. In the subgroup analysis for nutritional adequacy (n = 99), no association with mortality was observed.

Conclusion
Performance of NUTRIC score with SAPS 3 is similar to the original tool. Therefore, it might be used in settings where APACHE II is not available.
Symptoms of depression, anxiety and stress in patients with chronic otitis media
Authors: Jotic Ana D. , Opankovic Ana M. , Radin Zorana Z. , Cvorovic Ljiljana , Vujovic Katarina R. Savic , Krejovic-Trivic Sanja B. , Bukurov Bojana M. , Milicic Biljana R. , Stojanovic Jasmina D. 
Published: July 2022

Purpose
Persistent symptoms of chronic otitis media cause limitations in daily routine and social interactions, influencing significantly patients’ quality of life and mental health. The purpose of the study was to assess the intensity depression, anxiety and stress symptoms in patients with chronic otitis media and to examine if patient demographic data, characteristics and reported symptoms of otitis influence reported depression, anxiety and stress symptoms.

Material and methods
The study included 316 adult patients diagnosed with unilateral or bilateral chronic otitis media with or without cholesteatoma. Patients underwent a complete otological, audiological and radiological assessment. Chronic otitis media questionnaire 12 (COMQ-12) was used to assess the impact of COM and Depression Anxiety Stress Scale 21 (DASS-21) was used for depression, anxiety and stress assessment.

Results
Some level of anxiety and stress were detected in 70.57% 49.37% of the patients, respectively. 13.29% of the patients had scores indicating depression disorder. The mean value of the COMQ-12 questionnaire for this group of patients was 26.24 (SD±11.47) More intense symptoms of COM were significantly associated (p<0.05) with higher scores on DASS-21 subscales. Multivariate logistic regression analysis indicated that significant positive predictors of higher anxiety scores were pure tone average (PTA) on better and worse hearing ear (p<0.05). Drainage from the ear, hearing problems at home and tinnitus were significant positive predictors of a higher DASS-depression score. (p<0.05)

Conclusion
The study confirmed positive correlation between reported level of anxiety, depression and stress, severity of COM symptoms and quality of life. Level of hearing on the better and worse hearing ear were significant positive predictors of anxiety and stress in patients with COM.
Uvular Necrosis: A Rare Complication After Esophagogastroduodenoscopy in an Intubated Patient
Authors: Bhatia Unnati , Barrett Stevi , Bajaj Suryansh , Bi Yan 
Published: July 2022

ABSTRACT
Uvular necrosis is a potential etiology of postesophagogastroduodenoscopy persistent sore throat and odynophagia, and physicians should be alert to the possibility of this potential complication. Diagnosis is clinical and can be made on the basis of symptoms and characteristic findings on oropharyngeal examination. It has a benign course with an overall good clinical outcome. Conservative symptomatic management is the treatment of choice, and full recovery can be expected in 2 weeks. Keeping oropharyngeal instruments and ventilation tubes to the side of the midline, avoidance of blind suctioning, and decreasing the power of suction devices are some of the measures, which might reduce the risk of intraprocedure uvular injury. In addition, it is important to note that the risk of injury is higher in some individuals, for instance, patients with a long uvula, and it might be beneficial to take extra precautions in these patients.
Acute Severe Ulcerative Colitis After mRNA Coronavirus Disease 2019 Vaccination: Can mRNA Vaccines Unmask Inflammatory Bowel Diseases?
Authors: Ak Çağatay , Sayar Süleyman , Adalı Gupse , Özdil Kamil 
Published: July 2022

ABSTRACT
BNT162b2 is a messenger RNA vaccine for the prevention of the novel coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 infection. The widespread use of this vaccination has brought along several adverse events. We present a patient with newly diagnosed ulcerative colitis after BNT162b2 vaccine.
Spontaneous Migration of Spiral Fin Overtube During Motorized Spiral Enteroscopy
Authors: Rajput Sanjay , Bhatt Pratin , Bachkaniwala Vatsal , Gandhi Chaiti , Bokarvadia Ravi , Pipavat Rushi , Tadkalkar Varun 
Published: July 2022

ABSTRACT
Motorized spiral enteroscopy (SE) is a novel technique for evaluation and management of small bowel lesions. Total enteroscopy rates are higher with SE. Power spiral tube with spiral soft fin helps in advancement of the scope. SE has low adverse event profile; however, perforation and pancreatitis have been reported. We report the unusual adverse event of power spiral tube with spontaneous dislodgement of spiral fin in 2 cases.
Atypical Presentation of Left Hepatic Artery Pseudoaneurysm
Authors: Niaz Murk , Khan Muhammad Arsalan , Muhammad Shah , Khan Abdaal Waseem 
Published: July 2022

ABSTRACT
Hepatic artery pseudoaneurysm (HAP) commonly occurs after trauma and is rarely seen as a complication of pyogenic liver abscess. Patients with HAP can present with hemobilia secondary to arterobiliary fistula. We report a case of a 29-year-old woman who presented with abdominal pain, fever, and jaundice, who was diagnosed to have a pyogenic liver abscess that had led to the development of left HAP, presenting with hemobilia. The patient was successfully managed with endovascular coil embolization.
Anwendung eines künstlichen Neuronalen Netzes zur Verschleißbestimmung von Zerspanwerkzeugen
Authors: Esch Philipp , Werner-Jäger Florian 
Published: July 2022

Zusammenfassung
Die Optimierung von Zerspanprozessen erfordert ein grundlegendes Verständnis des Werkzeugverschleißverhaltens. Um hierauf künstliche Intelligenzalgorithmen anlernen zu können, ist eine Auswahl an signifikanten und technisch relevanten Kennwerten notwendig. Diese Arbeit präsentiert eine Methode zur Datenselektion und -skalierung, um die Anwendungsanforderungen einer künstlichen Intelligenz zu erfüllen. Die entwickelte Lösung zeigt auf Basis reduzierter experimenteller Umfänge eine hohe Übereinstimmung mit den gemessenen Verschleißkennwerten.
Stepping quantum genetic algorithm-based LQR control strategy for lateral vibration of high-speed elevator
Authors: Li Li , Qiu Tian , Jia Tichang , Chen Chen 
Published: July 2022

AbstractTo effectively restrain the lateral vibration caused by the guide rail excitation and improve the ride comfort of the car system, a state-weighted linear quadratic regulator (LQR) control strategy is proposed. Firstly, based on the active control model of the 4-DOF car system with actuators distributed diagonally along the center of the car frame, an LQR controller for lateral vibration of high-speed elevator car systems is designed. Furthermore, in view of the tedious and time-consuming of the empirical method to choose state-weighted matrixQ, stepping quantum genetic algorithm (SQGA) is proposed to improve the performance of the controller. Finally, the time-frequency characteristic curves of the lateral vibration acceleration and the vibration displacement of the car system are compared and analyzed by MATLAB to verify the effectiveness of the proposed controller.
Precision tracking control of a dual-stage measuring machine
Authors: Ringkowski Michael , Arnold Eckhard , Hartlieb Simon , Haist Tobias , Osten Wolfgang , Sawodny Oliver 
Published: July 2022

Abstract
Modern production requires shorter measuring cycles of measuring machines, which can be achieved with highly dynamic references causing dynamic deviations of the actual tool-center-point (TCP) position. To minimize the TCP tracking error, the considered measuring machine is extended with a redundant axis and a modular control concept is proposed. For this dual-stage actuation setting, a higher-level reference allocation module exploits the resulting redundancy and yields suitable position references for the lower-level controlled subsystems. On the higher-level, two dual-stage control concepts are presented, yielding both significantly reduced tracking errors in experiments compared to using only the main axis. Furthermore, to deal with strongly spatially varying friction of the main axis of the considered measuring machine, its lower-level control system is improved.
Book review on Workgroups e-assessment: planning, implementing and analyzing frameworks
Authors: Li Liang 
Published: July 2022

Abstract
This review includes a brief description of the concepts of collaboration and assessment, an introduction to e-assessment approaches, a range of digital tools and their applications, and an explanation of underlying paradigms and theoretical frameworks, followed by a critical evaluation of the values and merits as well as the weak points of the book in question. The paper is intended to shed light on a new era of language educational assessment and provide reference points for relevant studies.