bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exogenous Policy, Racial Avoidance, and the Qualified Relevance of Macroeconomic Change to Metropolitan Inequality
Authors: Johnson Odis 
Published: May 2022

Context: The rich contextualization of educational processes brought about in the pioneering work of Jean Anyon pushed scientists to acknowledge that the education being provided to the least advantaged was shaped by factors with origins beyond school and family environments. Political economic work in education has subsequently argued that an unforgiving economy has lessened the educational fortunes of urban residents. Focus of Study: In response to claims that macroeconomic change created the confinement of educational disadvantage, this article reveals that political economic arguments predicated on macroeconomic change have yet to explain a period of decline on several dimensions of educational inequality from 1970 to 1990. Research Design: Through a juxtaposition of historical population trends and research with the ideas of Anyon and her contemporaries, this analysis considers racial forces emanating from desegregation policy as key to understanding test-score trends and metropolitan restructuring. Descriptive analyses of test-score trends and neighborhood indices of dissimilarities from 1970 to the mid-1990s form the basis of analysis. Conclusions: The analysis demonstrates that not only does desegregation policy align with anomalous educational trends, but that its impact reverberated to other spatial strata through its encouragement of Whites’ school selection decisions intent on racial avoidance. Racial avoidance should therefore be considered as an architect of the racial and economic landscape of the modern metropolis.
Percutaneous dilatation tracheotomy in patients on extracorporeal membrane oxygenation after cardiac surgery
Authors: Xin Meng , Wang Liangshan , Li Chenglong , Hou Dengbang , Wang Hong , Wang Jiangang , Jia Ming , Hou Xiaotong 
Published: May 2022

Background Current practices regarding percutaneous dilatational tracheostomy in adult patients treated with extracorporeal membrane oxygenation (ECMO) after cardiac surgery is not completely defined. This study aimed to evaluate the safety of the percutaneous dilatational tracheostomy in patients with ECMO after cardiac surgery. Methods Between July 2017 and May 2021, 371 ECMO procedures were performed in more than 35,000 adult patients who underwent cardiac surgery in our hospital. Sixty-two patients underwent percutaneous dilatational tracheostomy (PDT) during or after ECMO. A retrospective analysis was performed comparing the incidence of complications and clinical outcomes of the two groups. Results Of the 371 patients treated with ECMO after adult cardiac surgery during the enrollment period, 22 (7.1%) and 40 (12.8%) underwent PDT during or after ECMO, respectively. The platelet count (PLT) of the day was significantly lower in the PDT during ECMO group (54 (34, 68) vs. 108 (69, 162) (thousands), p < 0.001)). The prothrombin time (PT) and activated partial thromboplastin time (APTT) of the day were longer in the PDT during ECMO group (15.8 (14.6, 19.9) vs. 13.8 (13.2, 15.2) seconds, p = 0.001, 43.8 (38.0, 49.4) vs. 35.2 (28.2, 40.9) seconds, p < 0.001, respectively). There was no significant difference in tracheotomy-related complications between the two groups. Significantly decreased ventilator time was observed in the PDT during ECMO group. Conclusions Despite poor coagulation of the day, PDT during ECMO is safe and can appropriately reduce the duration of mechanical ventilation compared with PDT after ECMO weaning in adult patients who have undergone cardiac surgery.
Correlation of KMT2 family mutations with molecular characteristics and prognosis in colorectal cancer
Authors: Liao Cun , Huang Wei , Lin Minglin , Li Hui , Zhang Zihan , Zhang Xiaolong , Chen Rongrong , Huang Mingfeng , Yu Pengli , Zhang Sen 
Published: May 2022

Background Lysine methyltransferase 2 (KMT2) family proteins methylate lysine 4 on histone H3 (H3K4) to promote genome accessibility and transcription. Dysregulation or mutation of KMT2 family have been observed frequently in various types of human cancers. Colorectal cancer is the third most common cancer worldwide. However, few studies have evaluated the role of KMT2 family mutations in colorectal cancer. The present study aimed to explore the impact of KMT2 family mutations on clinicopathological, molecular characteristics and prognosis in colorectal cancer. Methods A total of 316 colorectal cancer patients were enrolled; tumor tissue and matched peripheral blood samples were collected and subjected to targeted sequencing with a panel of 1021 cancer-related genes. The association of clinical pathological features and molecular characteristics in patients were then analyzed. The cBioPortal dataset was used for investigating the KMT2 family mutations data and their correlation with clinical outcomes. Results The overall mutation frequencies of KMT2A-D were 9.5%, 0.5%, 13%, and 13%, respectively, which were more often present at right-sided primary and earlier stage tumors. KMT2A-D mutations are associated with enhanced genomic instability, including a higher level of microsatellite instability (MSI-H) and tumor mutational burden (TMB-H). In addition, our results highlight the co-occurring gene mutations within the Wnt signaling, ERBB2/4, TGF-β superfamily pathway, and PI-3-kinase pathway in KMT2-mutant colorectal cancer. KMT2 family mutations were predictive biomarker for better overall survival in metastatic colorectal cancer. Conclusions Collectively, we identified that KMT2 family mutations were correlated with higher-TMB and higher-MSI, thus resulting in a better outcome for colorectal cancer patients.
Informality on the rise: Dissecting quasi-formal employment in the EU
Authors: Cichocki Stanislaw , Franic Josip 
Published: May 2022

AbstractIn spite of a growing body of literature on quasi-formal employment in the European Union (EU), there is still limited knowledge regarding the exact functioning of this illegal employment scheme. To fill this gap, we report data from the 2019 Special Eurobarometer on undeclared work, which reveals that 30.1% of European workers have higher income from employment than reported to tax authorities. Explicitly, 2.6% of registered dependent employees are entitled to cash top-ups to the official wage, for 7.8% of them the amount of supplementary payments depends on the work efforts, whereas 9.2% receive informal remuneration under multiple arrangements. In addition to these ‘regular recipients’, we also found that 10.5% of employees in the EU can be classified as ‘sporadic quasi-formal workers’. Besides showing that wage underreporting is far more pervasive than previously assumed, the study also offers a more nuanced insight into different manifestations of this illicit practice in the EU. Results of a two-level random intercept multinomial logit model reveal that women are less likely to receive fixed and variable cash-in-hand payments, whereas older individuals have a lower propensity to receive work-time-related income. The analysis also highlights that professionals, service sector employees, manual job workers and individuals whose jobs require travelling are more prone to variable wages compared to the rest of the population. Given a modest success in combating the phenomenon to this date, these findings will be particularly valuable for policymakers in their endeavours to devise tailored policy measures.
Predictive factors for community integration among Nepalese persons after traumatic brain injury
Authors: Lama Sumana , Damkliang Jintana , Kitrungrote Luppana 
Published: May 2022

Background Various factors affect the community integration (CI) of persons experiencing traumatic brain injury (TBI). To ensure positive outcomes in terms of life at home, social activities, and productive work among persons suffering TBI, it is necessary to understand the factors that facilitate or impede CI. Purpose To compare CI by looking at demographic and clinical characteristics and determine significant predictors of CI among TBI Nepalese persons. Methods 120 participants were selected using a stratified random sampling technique. A questionnaire was used to identify the participants’ demographic and clinical characteristics, and the Community Integration Questionnaire was used to measure CI. Univariate and multivariate analyses were performed for demographic and clinical factors associated with community integration. Results Using univariate analysis, male, employed, living with family, and independence in performing activities of daily living had significantly higher CI scores than female (t = −4.18, p<.000), unemployed (t = −10.52, p<.000), living with friends (t = −3.30, p<.001), and those with moderate to slight dependence (t = −2.83, p<.005). The multivariate analysis revealed that employment status, living with family, and length of hospital stay were significant predictors of CI among TBI Nepalese persons. Conclusion Employment status, living with family, and length of hospital stay were significant predictors of CI. These findings suggest that rehabilitation efforts should focus on minimizing hospital stay and promoting both productive and social activities among people surviving TBI.
A Systematic Review and Meta-Analysis of Enhanced Recovery for Open Abdominal Aortic Aneurysm Surgery
Authors: Docherty Jack , Morgan-Bates Kersten , Stather Philip 
Published: May 2022

Introduction: Open abdominal aortic aneurysm (AAA) surgery is associated with significant morbidity, mortality and high length of stay (LOS). Enhanced recovery is now commonplace and has been shown to decrease these in other non-vascular surgery settings. This systematic review and meta-analysis aimed to assess the benefits of enhanced recovery (ERAS) in aortic surgery. Method: Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines were used to undertake a systematic review via Ovid MEDLINE and Embase on 10.07.2021. The search terms were “aortic aneurysm” and “fast track” or “enhanced recovery”. Data was obtained on major complications, 30-day mortality and LOS. Results: 107 papers were identified and 10 papers included for meta-analysis. Complication rates were significantly reduced with ERAS compared to non-ERAS protocols (ERAS n = 709, non-ERAS n = 930) (odds ratio .38, .22 to .65: P = .0005). LOS was also significantly reduced with an ERAS protocol (ERAS n = 708, non-ERAS n = 956) with a mean reduction of 3 .18 days (−5.01 to −1.35 days) ( P = .0007: I2 = 97%). There was no significant difference however in 30-day mortality ( P = .92). Conclusion: This meta-analysis demonstrates significant benefits to an enhanced recovery programme in open AAA surgery. There is a need for a multi-centre randomized controlled trial to assess this further.
Corporate social and community-oriented support by UK food retailers: a documentary review and typology of actions towards community wellbeing
Authors: Lee C , Hammant C 
Published: May 2022

Aim: This article provides a comprehensive exploration of the varied Corporate Social Responsibility (CSR) actions in relation to supporting communities reported by the UK’s leading food retailers. Findings are discussed against a backdrop of enduring inequalities, exacerbated by the on-going global Coronavirus pandemic, with actions considered for their potential contribution to community-based approaches to addressing local wellbeing and inequalities. Method: This article presents the structure and key characteristics of community-oriented CSR in food retailing in the UK. A thematic analysis of comprehensive documentary evidence from the 11 principle UK food retailers was conducted, drawing on asset-based frameworks of community-centred actions towards wellbeing. Findings: The findings suggest an increasing acknowledgement in food retail that local community is of key importance. Initiatives were categorised according to a typology, comprising national partnerships, local store-based funding and support actions, targeted programmes on healthy lifestyles or employability, and changes to store operations, in the favour of priority groups, prompted by the pandemic. Conclusion: The article combines an up to date overview of community-focused CSR agendas and support by food retailers at a time of significant economic and social challenge for the UK. It highlights the potential of the sector to contribute more strategically to reducing inequalities and supporting community wellbeing, alongside statutory and voluntary sector partners.
Vertebral Hemangiomas: Prevalence, new classification and natural history. magnetic resonance imaging-based retrospective longitudinal study
Authors: Abul-Kasim Kasim , Persson Erik , Levinsson Anders , Strömbeck Anita , Selariu Eufrozina , Ohlin Acke 
Published: May 2022

Background and purpose: To determine the prevalence of vertebral hemangiomas (VHs), establish a new classification of VHs based on their MRI-signal pattern, and study their natural history. Methods MRI of 1000 consecutive patients who underwent at least two MRI with an interval of at least 3 years. Growth rate and change of MRI-signal pattern during the follow-up period were the parameters included in studying the natural history of VHs. Results The prevalence of VHs was 41%. VHs were classified as type I–IV with fat-rich VHs (type I), constituted 79% of all VHs. VHs were more common among females 43% versus males 39%, p = .22. The most affected vertebra was L1. Occurrence rates for cervical (1%), thoracic (7%), and lumbar spine (10%) differed significantly ( p < .001). The prevalence of VHs increased with age regardless of gender or spinal part involved ( p < .001). Only 26% of VHs changed their size and 4% changed their signal during the average follow-up of 7 years. All VHs were slowly growing lesions (average expected growth of <3 mm/10 years). No significant difference between growth rate of VHs type I (0.25 mm/year) and other types of VHs. None of the VHs that were initially reported as “metastases cannot be rule out” showed alarming change in signal or size. Conclusions VH can be classified into four types based on their MRI-signal pattern. Regardless of their type, VHs are slowly growing lesions. The presence of typical morphological pattern should enable radiologists to confidently differentiate them from vertebral metastases.
Platelet mitochondrial membrane depolarization reflects disease severity in patients with preeclampsia
Authors: Kraemer Bjoern F. , Hennis Irina , Karge Anne , Kraemer Anne Katrin , Dreyer Tobias F. , Kiechle Marion , Kuschel Bettina , Bronger Holger 
Published: May 2022

AbstractBackgroundThrombocytopenia is a feared complication of preeclampsia (PE) that can additionally complicate the disease course and that carries a poor prognosis. The disease mechanisms of PE on a platelet level are poorly understood and only few platelet-based markers have been investigated. In sepsis, platelet mitochondrial membrane depolarization, a sensitive and early indicator of mitochondrial dysfunction and platelet cell death, correlates with disease severity and outcome as shown in previous studies. The aim of this study was to investigate platelet mitochondrial membrane potential (Mmp-Index) by flow-cytometry in patients with preeclampsia compared to controls and to assess its value in correlation with disease severity of PE and during follow-up after delivery.MethodsIn this prospective translational case–control study, platelet Mmp-Index was measured in PE (n = 16) by flow cytometry in living platelets in simultaneous comparison to healthy pregnant (n = 32) and non-pregnant controls (n = 16) and was individually reassessed after delivery to investigate recovery of platelet mitochondrial function. Subgroup analysis of patients with severe and non-severe PE was performed. Six patients with isolated gestational hypertension were also included for comparative analysis.ResultsPlatelet Mmp-Index in patients with symptomatic preeclampsia (Mmp-Index non-severe PE 0.72 ([0.591; 0.861]; p = 0.002) was significantly reduced compared to healthy pregnant controls (Mmp-Index 0.97 [0.795; 1.117]) and even more pronounced in patients with severe PE (n = 6) (Mmp-Index severe PE 0.542 [0.361; 0.623]; p = 0.03). In the severe PE group, complementary measurements of platelet Annexin V- and CD62 (P-Selectin) surface expression showed apoptosis of platelet populations in the majority of patients. Platelet Mmp normalized after delivery within few days. Patients with isolated gestational hypertension showed normal Mmp-Index values.ConclusionsThis study shows for the first time that platelet Mmp-Index is a quantifiable, easy-to-measure intracellular marker of platelet mitochondrial function in vital cells that reflects disease severity of preeclampsia. For future investigations, platelet Mmp may serve as a prognostic marker that may aid clinical risk stratification and adds novel information on potential mechanisms for thrombocytopenia in preeclampsia.
Formation Principle and Characteristics of Self-Supercharging Pulsed Water Jet
Authors: Ge Zhaolong , Ling Yuanfei , Tang Jiren , Lu Yiyu , Zhang Yangkai , Wang Lei , Yao Qi 
Published: May 2022

AbstractHigh-pressure pulsed water jet technology has considerable development potential in the field of rock fragmentation. To overcome the shortcomings of existing pulsed jets, a self-supercharging pulsed water jet (SSPWJ) generation method is proposed, which is based on the theory of the pulsed water jet and the principle of hydraulic boosting. The proposed method changes the flow direction of the fluid medium through the valve core to make the piston reciprocate in the cylinder and relies on the effective area difference between the front and rear chambers in the stroke stage of the piston to realize the organic combination of “pulse” and “supercharging” of the jet, thus forming an SSPWJ. On the basis of the formation principle of the SSPWJ, a SSPWJ testing platform was constructed, and tests were performed on the jet pressure acquisition, morphology capture, and granite erosion. Both the jet pressure and the jet morphology exhibited periodic changes, and a higher pulse pressure was obtained at lower inlet pressure. The error of the pressure ratio calculated according to the experimental results was <3% relative to the theoretical design value, confirming the feasibility of the method. The pulse pressure and pulse frequency are controllable; that is, as the inlet flow rate increases in the stroke stage of the piston, the pulse pressure and pulse frequency increase, and the pulse duration decreases. As the inlet flow rate increases in the backward-stroke stage of the piston, the pulse frequency increases, and the pulse pressure and pulse duration remain unchanged. Under the combined action of the water-hammer pressure, high-speed lateral flow, and high-frequency dynamic load of the SSPWJ, local flaky exfoliation was observed when the granite surface was eroded. The results of this study lay the foundation for enriching the theory of pulsed jet generation and expanding its application range.
Influence of Charging Oil Condition on Torque Converter Cavitation Characteristics
Authors: Liu Cheng , Guo Meng , Yan Qingdong , Wei Wei 
Published: May 2022

AbstractCavitation inside a torque converter induces noise, vibration and even failure, and these effects have been disregarded in previous torque converter design processes. However, modern torque converter applications require attention to this issue because of its high-speed and high-capacity requirements. Therefore, this study investigated the cavitation effect on a torque converter using both numerical and experimental methods with an emphasis on the influence of the charging oil feed location and charge pressure. Computational fluid dynamics (CFD) models were established to simulate the transient cavitation behaviour in the torque converter using different charging oil pressures and inlet arrangements and testing against a base case to validate the results. The CFD results suggested that cavitating bubbles mainly takes place in the stator of the torque converter. The transient cavitation CFD model yielded good agreement with the experimental data, with an error of 7.6% in the capacity constant and 7.4% in the torque ratio. Both the experimental and numerical studies showed that cavitation induced severe capacity degradation, and that the charge pressure and charging oil configuration significantly affects both the overall hydrodynamic performance and the fluid behaviour inside the torque converter because of cavitation. Increasing the charge pressure and charging the oil from the turbine-stator clearance were found to suppress cavitation development and reduce performance degradation, especially in terms of the capacity constant. This study revealed the fluid field mechanism behind the influence of charging oil conditions on torque converter cavitation behaviour, providing practical guidelines for suppressing cavitation in torque converter.
Prevalence of preoperative Deep Venous Thrombosis (DVT) following elderly intertrochanteric fractures and development of a risk prediction model
Authors: Wang Xiaofei , Jiang Zhen , Li Yufu , Gao Kai , Gao Yang , He Xiaoli , Zhou Hongyan , Zheng Wei 
Published: May 2022

Abstract
Background
This study aimed to investigate the prevalence of preoperative deep venous thrombosis (DVT) following intertrochanteric fractures in the elderly and identify the associated factors, based on which a risk prediction model was developed.

Method
This was a retrospective single-center study of elderly patients presenting with intertrochanteric fractures between our institution between January 2017 and December 2020. Patients' duplex ultrasound (DUS) or venography results were retrieved to evaluate whether they had a preoperative deep venous thrombosis (DVT) of bilateral extremities, whereby patients were dichotomized. Various variables of interest on demographics, comorbidities, injury and biomarkers were extracted and their relationship between DVT were investigated. Statistically significant variables tested in multivariate logistics regression analyses were used to develop a risk prediction model.

Results
There were 855 patients eligible to be included in this study, and 105 were found to have preoperative DVT, with a prevalence rate of 12.3%. Ten factors were tested as significantly different and 2 marginally significant between DVT and non-DVT groups in the univariate analyses, but only 6 demonstrated the independent effect on DVT occurrence, including history of a VTE event (OR, 4.43; 95%CI, 2.04 to 9.62), time from injury to DVT screening (OR, 1.19; 95%CI, 1.13 to 1.25), BMI (OR, 1.11; 95%CI, 1.04–1.18), peripheral vascular disease (OR, 2.66; 95%CI, 1.10 to 6.40), reduced albumin (2.35; 95%CI, 1.48 to 3.71) and D-Dimer > 1.0 mg/L(OR, 1.90; 95%CI, 1.13 to 3.20). The DVT risk model showed an AUC of 0.780 (95%CI, 0.731 to 0.829), with a sensitivity of 0.667 and a specificity of 0.777.

Conclusion
Despite without a so high prevalence rate of DVT in a general population with intertrochanteric fracture, particular attention should be paid to those involved in the associated risk factors above. The risk prediction model exhibited the improved specificity, but its validity required further studies to verify.