bluuebunny/crossref_metadata_2025_split huggingface dataset:
Te Pua Keith Park – Nau mai, Haere mai Let’s Play Together
Authors: Copeland Elise , Stringer Jennice , Naylor Vivian , Rim Lee Sue 
Published: July 2022

Te Pua/Keith Park playground employed an innovative early program of co-design with an All Abilities Project Group (AAPG), representing disability organisations and key stakeholders from the community. Through ongoing engagement with disabled people as experts, the outcome was an inclusive and welcoming play space for a diverse range of children, young people and their caregivers.Play equipment included a range of vestibular, visual, and auditory pieces as well as a customised 2m high wheelchair accessible play tower for inclusive play experiences. Caregivers were enabled to play with their children through smooth and step-free surfaces as well as specific play equipment such as an adult and child swing. Children and young people of different ages and abilities were encouraged to sit/lie/stand in the basket swing and see-saw together. Unique to this playground, communication boards were innovatively and collaboratively designed with visual images representing various features of the playground and QR codes linking to online videos with New Zealand Sign Language.In addition to play equipment, the AAPG identified that the toilet facilities were crucial to ensuring accessibility to many families, including those with bigger children or teens with access needs who were often faced with the reality of needing to be changed in unsanitary and unsafe ways without the appropriate facilities being available. Keith Park worked with a leading toilet manufacturer to co-design a bespoke double toilet block with enhanced accessibility features including an adult-sized change table.Every aspect of the park was carefully selected and designed including fencing, furniture, plants and colours. Colour enhanced accessibility by guiding children with low vision and created a play circuit to assist the neurodiverse community. The resultant playground is one that welcomes all to play, which is a core tenet of child development, socialisation and participation.

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A Proposed Laboratory Method to Evaluate the Durability of Concrete Pavement Joints Against Freezing in the Presence of Deicer Salts
Authors: Elbakari, Ramy , Shehata Medhat 
Published: July 2022

<p> Deicer salts were found to cause deterioration to the concrete pavement, particularly at joints. This paper introduces a laboratory procedure that engineers and scientists can use to evaluate the durability of joints. Concrete samples were tested under different salt concentrations and exposure conditions, including freeze-thaw cycles, wet-dry cycles, and a combination thereof. The test sample comprises a square slab measuring 200x200x120 mm and a joint running in the middle at 40 mm depth. The results showed that the test method needs to include two salts with two exposure conditions for accelerated damage. The first exposure uses NaCl at 10% concentration with 50 cycles of freeze/thaw-wet/dry alternating every five consecutive cycles. The second exposure uses CaCl2 at 15% concentration with 50 cycles of wetting and drying at 5°C and 35 °C, respectively. Damage is assessed using two approaches: 1) strength loss under flexural loading and 2) visual damage </p>
PROCEDIMENTOS PARA ADOÇÃO DE VENDAS ONLINE: ESTUDO NO VAREJO TÊXTIL
Authors: Padilha Edilson Sidnei , Padilha Carolina Klein , Garcia Bruno Kaue 
Published: July 2022

O surgimento de novas tecnologias tem possibilitado novas realidades de negócios. Um modelo de negócio possível diante dessa nova realidade é a realização de vendas via e-commerce que vem despertando grande atenção de empreendedores devido aos baixos custos da modalidade de vendas e grande abrangência ao seu público-alvo. O presente estudo tem o objetivo de analisar os procedimentos necessários para adoção de vendas online, incluindo parcerias através de marketplaces e comparativos de custos operacionais. Trata-se de uma pesquisa descritiva com coleta de dados por meio documental e abordagem qualitativa. Como resultados da pesquisa averiguou-se que os procedimentos a serem tomados para a adoção de uma loja e-commerce são complexos, tendo seu início na resolução de processos mais burocráticos exigidos pela legislação do país e se estende até a integração de todos os parceiros envolvidos nas operações do negócio. O estudo mostrou a preocupação necessária com a manutenção da visibilidade dos itens da empresa nos canais de venda, e o cálculo para a aplicação de um preço justo nos produtos de cada canal.
Palavras-Chave: E-commerce. Integração. Custos.

Abstract: The emergence of new technologies has enabled new business realities. A possible business model in the face of this new reality is making sales via e-commerce, which has been attracting great attention from entrepreneurs due to the low costs of the sales modality and wide coverage to its target audience. The present study aims to analyze the necessary procedures for the adoption of online sales, including partnerships through marketplaces and operational cost comparisons. This is a descriptive research with data collection through documents and a qualitative approach. As a result of the research, it was found that the procedures to be taken for the adoption of an e-commerce store are complex, starting with the resolution of more bureaucratic processes required by the legislation of the country and extending to the integration of all the partners involved. in business operations. The study showed the necessary concern with maintaining the visibility of the company's items in the sales channels, and the calculation for the application of a fair price to the products of each channel.
Keywords: E-commerce. Integration. Costs.
DEVELOPING INTEGRATED ENGLISH SYLLABUS FOR MARINE SCIENCE STUDENTS AT BENGKULU UNIVERSITY
Authors: Febrianty Vina , Syahrial Syahrial , Harahap Alamsyah 
Published: July 2022

An Integrated English Syllabus is a syllabus that integrate one to several language skills of learning and teaching process. They cover elements of English skills, English materials, learning techniques, and so on. In this study, the researcher use Research and Development method by Sugiyono (2010). The purposes of this study are to find out the English skills and the English materials that really needed by Marine Science Students. In addition, focuses on developing an Integrated Syllabus with Marine Science context. In designing Integrated Syllabus the researcher use integrated model by Richard (2001). To collect the data the researcher use interview and questionnaire. The parcipants are 1 English lecturer, 1 Marine Science Lecturer, 2 stakeholders (Water and Marine Police at Pulau Baai Bengkulu and Employee at Marine Affairs and Fisheries at Bengkulu Province), and 8th semester Marine Science Students at Bengkulu University. The result of this study showed that the Marine Science students needs the four of English skills and English materials but the most needed are writing and reading. Therefore, the researcher designed an Integrated Syllabus that is suitable with Marine Science Study Program especially at Bengkulu University. From the research, it can be seen that the English needs of marine science students at Bengkulu University. Then, the syllabus developed in this study can be used as a reference in preparing English courses in the Marine Science study program.
formación del docente de la educación a distancia
Authors: Vargas Monzón Emgelberth Danilo 
Published: July 2022

El presente documento se ha elaborado a partir de un proceso de investigación hermenéutico enfocado en la lectura crítico-constructiva de diferentes publicaciones referidas al papel que pueden juagar las universidades para superar el impacto de la pandemia en la educación. Como una manera de contener la expansión del Covid-19, las instituciones educativas convencionales asumieron la modalidad a distancia sin que los actores educativos conocieran teoría-práctica de esa modalidad. Ya han transcurrido más de dos años, y es menester salir del modo de contingencia para acceder al modo de planificación. Esto supone la formación de un docente que mediante su actuación demuestre la eficiencia y pertinencia de la Educación a distancia (EaD). Consecuentemente, se propone que las universidades responsables de la titulación de los profesionales de la docencia construyan y desarrollen una reforma curricular.
Peran Pemerintah dalam Perlindungan Tenaga Kesehatan Terpapar Covid–19
Authors: Effendi Rustam , Handayani Handayani 
Published: July 2022

Angka kejadian Covid-19 di Indonesia terkonfirmasi sangat tinggi. Angka sebaran per tanggal 27 Juni 2021 terkonfirmasi 2.093.962, meninggal 56.729 dan sembuh 1.842.457. Peran pemerintah dalam perlindungan tenaga kesehatan sangat dibutuhkan. Beberapa kebijakan dari pemerintah termaktub di dalam ketetapan peraturan diantaranya adanya pemberian bonus dan kompensasi kematian bagi tenaga kesehatan serta program vaksin Covid-19 bagi tenaga medis. Upaya pemerintah dalam mencegah penyebaran dan penularan virus Corona diantaranya kebijakan stay at home, memakai masker, dan mencuci tangan. Penelitian ini bertujuan untuk menganalisis tahapan-tahapan yang sudah kerjakan oleh pemerintah Indonesia ketika menangani Covid-19 serta dalam melindungi tenaga kesehatan. Penelitian ini menggunakan systemic literature review. Dari 7 artikel yang didapat, Indonesia sudah menerapkan kebijakan pengendalian dan pencegahan penularan Covid-19. Kebijakan dari pemerintah membutuhkan dukungan, peran serta dan kesadaran masyarakat. Peraturan dan sistem kesehatan yang baik dan terorganisir dibutuhkan. Koordinasi yang terpola antar stake holder, khususnya pemerintah pusat dan pemerintah daerah, serta SOP pencegahan dan pengendalian Covid-19 diperlukan untuk menghambat penyebaran infeksi Covid-19 secara tuntas.
Hubungan antara Komponen Health Belief Model dengan Perilaku Pencegahan Covid-19 pada Masyarakat
Authors: Purnama Putri , Yulistiani Mustiah 
Published: July 2022

Ancaman global Covid-19 terus muncul dan korban terus bertambah sehingga penting meningkatkan pengetahuan dan persepsi masyarakat untuk membentuk perilaku tindakan pencegahan penularan Covid-19. Tujuan penelitian ini untuk mengetahui hubungan komponen health belief model dengan perilaku pencegahan Covid-19 pada masyarakat Kecamatan Langensari Kota Banjar Jawa Barat. Penelitian ini bersifat deskriptif analitis dengan desain cross-sectional. Responden penelitian ini adalah masyarakat kecamatan Langensari dengan jumlah sampel sebanyak 100 responden yang dipilih dengan teknik purposive sampling. Pengambilan data menggunakan kuesioner yang dibagikan melalui google form. Hasil uji chi-square memperoleh hasil perceived susceptibility sebesar 0,000, perceived severity sebesar 0,005, perceived benefit sebesar 0,000, perceived barriers sebesar 0,860, cues to action sebesar 0,000, self-efficacy sebesar 0,000 dan nilai signifikansi p<0,05. Ada hubungan antara perceived susceptibility, perceived severity, perceived benefit, cues to action, self-efficacy dengan perilaku pencegahan covid-19, tetapi tidak ada hubungan antara percived barriers dan perilaku pencegahan Covid-19 (p>0,005). Dari 6 komponen health belief model, self-efficacy memiliki nilai korelasi tertinggi dan berpengaruh dalam melakukan tindakan pencegahan Covid-19 sementara itu yang tidak berpengaruh adalah perceived barriers.
ELEMEN IDEMPOTEN DI GELANGGANG Z_n DAN KAITANNYA DENGAN HOMOMORFISMA GELANGGANG
Authors: Aditya Ricky , Herawati Maria Vianney Any 
Published: July 2022

Homomorfisma gelanggang merupakan salah satu topik yang dipelajari dalam perkuliahan aljabar abstrak untuk jenjang S1. Definisi dari homomorfisma gelanggang merupakan perluasan dari definisi homomorfisma grup, dengan sifat “mengawetkan struktur” berlaku untuk kedua operasi binernya. Karena aksiomanya lebih banyak, akan lebih sulit untuk mencari contoh-contoh dari homomorfisma gelanggang daripada contoh-contoh homomorfisma grup. Dalam makalah ini akan dikaji suatu karakterisasi dari homomorfisma gelanggang untuk kasus spesifik dari Z_m ke Z_n, yang ternyata berkaitan erat dengan elemen idempoten di gelanggang Z_n. Karakterisasi lebih detail untuk berbagai macam kemungkinan keterkaitan antara nilai m dan n juga akan dipaparkan. Dengan menggunakan karakterisasi-karakterisasi tersebut, akan lebih mudah bagi para dosen pengampu mata kuliah aljabar abstrak dalam memberikan contoh-contoh homomorfisma gelanggang.
Short-term and long-term alterations of gastrointestinal microbiota with different H. pylori eradication regimens: A meta-analysis
Authors: Chen Bing , Li Xin-meng , Cai Ting , Wang Fen 
Published: July 2022

Background and AimsThe impacts of Helicobacter pylori (H. pylori) eradication on the gastrointestinal microbiota are controversial, and whether the short-term and long-term changes in the gastrointestinal microbiota following different eradication regimens are consistent remains inconclusive. This study aimed to examine the effects of various eradication regimens on the gastrointestinal microflora at follow-up evaluations within 7 days, at 1–3 months, and over 6 months changes in the gastrointestinal microbiota.Materials and MethodsStudies reported on the PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrails.gov databases before March 2022 were collected. Data analysis and visualization were conducted using Review Manager 5.4.1. The tool of the Cochrane Collaboration to assess the risk of bias was suitable for randomized controlled trials with the Newcastle–Ottawa scale for nonrandomized controlled trials. In addition, the process was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.ResultsAfter a series of rigorous screenings, a total of 34 articles with 1,204 participants were included for this review analysis. The results showed changes in the gut microflora at the phylum level or the family and genus levels. After metronidazole-containing triple therapy, the number of Enterobacteriaceae increased at 1–3 months follow-up. After Metronidazole-free triple therapy, Actinobacteria decreased significantly, and this trend lasted for more than 6 months. Within 7 days after eradication treatment, the follow-up results showed a decrease in the number of Lactobacillus. After Bismuth-containing quadruple therapy, the changes in Actinobacteria fluctuated with the follow-up time. The changes in Proteobacteria showed a downward trend lasting for 1–3 months after eradication but returned to baseline levels over 6 months after eradication. Subgroup analyses indicated that host age could influence changes in the gut microbiota.ConclusionDifferent eradication regimens had varied effects on the short-term and long-term abundance of the gastrointestinal microbiota, but the decreasing trend of the microbiota diversity was the same for all regimens at the short-term follow-up. This study summarizes the changes of gut microbiota at different stages after different eradication regimens and hope to provide some references for supplementing probiotics, while further studies is needed to support these findings.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42021292726
The controlling nutritional status score and clinical outcomes in patients with heart failure: Pool analysis of observational studies
Authors: Huang Xian-Wen , Luo Jian-Jing , Baldinger Beatrice 
Published: July 2022

Background and aimsMalnutrition is very common in patients with heart failure (HF) and is associated with a worse clinical outcome. The Controlling Nutritional Status (CONUT) score is an easily derived index for the evaluation of malnutrition. This study aimed to evaluate the association between the CONUT score and the prognosis in patients with HF.Methods and resultsElectronic databases were searched for potential studies from inception up to February 15, 2022. Observational cohort studies included adult participants with HF, and reported the associations between the CONUT score and the adjusted relative risk (RR) of all-cause mortality, and patients with composite major adverse cardiac outcomes (MACEs) were included. We finally included 18 studies comprising 12,532 participants with HF for analysis. The median age of the patients was 70.5 years old, and 35.4% were women. After a median follow-up duration of 32.5 months, patients with HF with a higher CONUT score were associated with a higher risk of all-cause mortality (per 1 increment of the CONUT score: RR, 1.21, 95% CI, 1.13–1.29, I2 = 68%, P for heterogeneity = 0.002) and MACEs (per 1 increment of the CONUT score: RR, 1.14, 95% CI, 1.06–1.23, I2 = 81%, P for heterogeneity &lt;0.0001) after adjusting for other prognostic factors. When the CONUT score was divided into the normal nutritional status and malnourished status, malnourished patients with HF were associated with increased risks of all-cause death (RR, 1.61, 95% CI, 1.40–1.85, I2 = 17%, P for heterogeneity = 0.29) and MACEs (RR, 2.12, 95% CI, 1.49–3.02, I2 = 87%, P for heterogeneity &lt;0.0001), compared with those with normal nutritional status.ConclusionsThe CONUT score is associated with the clinical outcomes in patients with HF, and can be used as a screening tool of nutritional status in HF to improve prognosis.
Early-Onset Diabetes Mellitus in Chromosome 8p11.2 Deletion Syndrome Combined With Becker Muscular Dystrophy - A Case Report
Authors: Cao Conghui , Wang Xiaoli , Zhao Xiaojuan 
Published: July 2022

BackgroundChromosome 8p11.2 includes several key genes in development such as the FGFR1, ANK1, KAT6A, and SLC20A2 genes. Deletion of this fragment causes a contiguous gene syndrome. Currently, few cases of interstitial deletion of whole 8p11.2 have been reported. We report a rare case of 8p11.2 deletion syndrome with the unique phenotypes, presenting with early-onset diabetes.Case DescriptionA 20-year-old man with a 1-year history of diabetes mellitus was admitted to the Endocrinology Clinic. Physical examination revealed the dysmorphic facial features, and broad and foreshortened halluces. Laboratory examination indicated spherocytosis anemia, and hypogonadotropic hypogonadism. Bone mineral density analysis showed decreased bone density in the lumbar vertebrae. Brain CT showed calcification. Whole-exome sequencing revealed a 7.05-Mb deletion in 8p11 containing 43 OMIM genes, and a large in-frame deletion of exons 48–55 in the DMD gene. Metformin was given to the patient after which his blood glucose was well controlled. HCG was injected subcutaneously and was supplemented with calcium and vitamin D, which led to an improvement in the patient’s quality of life.ConclusionWe report a rare case of 8p11.2 deletion syndrome with unique phenotypes, and early-onset diabetes. It is challenging for endocrinologists to simultaneously reconcile a combination of these diseases across multiple disciplines. We discussed the influencing factors of early-onset diabetes in this patient and speculated that it was caused by complex interactions of known and unknown genetic backgrounds and environmental factors.
Leucine zipper downregulated in cancer 1 may serve as a favorable prognostic biomarker by influencing proliferation, colony formation, cell cycle, apoptosis, and migration ability in hepatocellular carcinoma
Authors: Chen Huaping , Chen Siyuan , Chen Chen , Li Aifeng , Wei Zhixiao 
Published: July 2022

Aims: Leucine zipper downregulated in cancer 1 (LDOC1) inhibits tumor growth in several cancers. However, the expression and function of LDOC1 in hepatocellular carcinoma (HCC) remain unknown. In this study, we aimed to investigate how LDOC1 influenced tumor progression and the biological functions of HCC.Methods: The transcription levels of LDOC1 were determined using the GEPIA and UALCAN online databases and a real-time polymerase chain reaction. Western blot and immunohistochemistry were used to validate the protein levels of LDOC1. The online Kaplan-Meier Plotter was applied for survival analysis. Then lentivirus transfection was used to construct LDOC1 exogenous overexpression cell lines. Proliferation, clone formation, cell cycle, apoptosis, and migration assays were performed with the LDOC1-upregulated Huh7 and Hep3B cell lines. The phosphorylated and total levels of AKT and mTOR were determined using a Western blot to explore the potential molecular mechanism of LDOC1.Results: In the GEPIA and UALCAN analyses, LDOC1 was lowly expressed in tumors, had high expression in normal tissue samples (p &lt; 0.05), and negatively correlated with tumor grade progression. The down-regulation of LDOC1 in HCC was validated with real-time polymerase chain reaction, Western blot, and immunohistochemistry (all p &lt; 0.05). LDOC1 transcription levels were negatively associated with overall, progression-free, recurrence-free, and disease-specific survival (all p &lt; 0.05). The functional experiments suggested that the overexpression of LDOC1 contributed to increased G1 and G2 stages in Huh7, while increased G2 stage in Hep3B, and decreased cell proliferation, clone formation, and migration, as well as increased the apoptosis rate compared with the control group (all p &lt; 0.05). Furthermore, LDOC1 up-regulation reduced the p-AKT/AKT and p-mTOR/mTOR, which indicates an inactivation of the AKT/mTOR pathway.Conclusion: The tumor-suppressor LDOC1 varied in HCC and non-HCC tissues, which can serve as a candidate prognostic biomarker. LDOC1 influenced survival by affecting proliferation, colony formation, cell cycle, apoptosis, and migration ability, which might be attributed to the AKT/mTOR inhibition in HCC.
Integrated analysis of mRNA-single nucleotide polymorphism-microRNA interaction network to identify biomarkers associated with prostate cancer
Authors: Wang Zhiwen , Zhu Xi , Zhai Hongyun , Wang Yanghai , Hao Gangyue 
Published: July 2022

Background: Prostate cancer is one of the most common malignancies among men worldwide currently. However, specific mechanisms of prostate cancer were still not fully understood due to lack of integrated molecular analyses. We performed this study to establish an mRNA-single nucleotide polymorphism (SNP)-microRNA (miRNA) interaction network by comprehensive bioinformatics analysis, and search for novel biomarkers for prostate cancer.Materials and methods: mRNA, miRNA, and SNP data were acquired from Gene Expression Omnibus (GEO) database. Differential expression analysis was performed to identify differentially expressed genes (DEGs) and miRNAs (DEMs). Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses, protein-protein interaction (PPI) analysis and expression quantitative trait loci (eQTL) analysis of DEGs were conducted. SNPs related to DEMs (miRSNPs) were downloaded from the open-source website MirSNP and PolymiRTS 3.0. TargetScan and miRDB databases were used for the target mRNA prediction of miRNA. The mRNA-SNP-miRNA interaction network was then constructed and visualized by Cytoscape 3.9.0. Selected key biomarkers were further validated using the Cancer Genome Atlas (TCGA) database. A nomogram model was constructed to predict the risk of prostate cancer.Results: In our study, 266 DEGs and 11 DEMs were identified. KEGG pathway analysis showed that DEGs were strikingly enriched in focal adhesion and PI3K-Akt signaling pathway. A total of 60 mRNA-SNP-miRNAs trios were identified to establish the mRNA-SNP-miRNA interaction network. Seven mRNAs in mRNA-SNP-miRNA network were consistent with the predicted target mRNAs of miRNA. These results were largely validated by the TCGA database analysis. A nomogram was constructed that contained four variables (ITGB8, hsa-miR-21, hsa-miR-30b and prostate-specific antigen (PSA) value) for predicting the risk of prostate cancer.Conclusion: Our study established the mRNA-SNP-miRNA interaction network in prostate cancer. The interaction network showed that hsa-miR-21, hsa-miR-30b, and ITGB8 may be utilized as new biomarkers for prostate cancer.