bluuebunny/crossref_metadata_2025_split huggingface dataset:
AFP and CA-125 as an accurate risk factor to predict eye metastasis in hypertension patients with liver carcinoma: A STROBE-compliant article
Authors: Tang Jing , Zhang Li-Juan , Kang Min , Huang Rong , Shu Hui-Ye , Wei Hong , Zou Jie , Pan Yi-Cong , Ling Qian , Shao Yi 
Published: September 2022

Purpose: In this study, we analyzed the differences between hypertension patients with ocular metastasis of liver cancer and those with metastases to other sites, the correlation between history of HBV and liver cancer metastasis, and independent risk factors for ocular metastasis.Methods: We used treatment records from 488 patients with metastases of primary liver cancer from August 2001 to May 2015, divided into two groups based on metastatic sites: OM (ocular metastasis) and NOM (non-ocular, other sites of metastasis) groups. The Student’s t-test and Chi-square test were used to assess the significance of differences between the groups and define the relationship between history of HBV and ocular metastasis of liver cancer. Binary logistic regression analysis was used to identify indicators of ocular metastasis of liver cancer and receiver operating curve (ROC) analyses to estimate their diagnostic value.Results: No significant differences in sex, age, tumor stage, pathological type, or treatment were identified between the OM and NOM groups, while the prevalence of HBV was higher in the former than that in latter. Binary logistic regression demonstrated that AFP and CA-125 were independent indicators of liver metastasis (both p &lt; 0.001). ROC curve analyses generated cut-off values for AFP and CA-125 of 957.2 ng/ml and 114.25 U/ml, respectively, with corresponding AUC values of 0.739 and 0.810. The specificity of the combination of AFP and CA-125 was higher than either factor separately.Discussion: To explore the diagnostic value of AFP and CA125 in predicting the development of ocular metastases of hypertensive patients with liver cancer, which will help us to diagnose the occurrence and development of the disease more accurately and make the best clinical diagnosis and treatment measures.
Structural insights into the binding of zoledronic acid with RANKL via computational simulations
Authors: Wang Ruijie , Zhang Wenjie , Ma Hailong , Zou Duohong , Zhang Zhiyuan , Wang Shaoyi 
Published: September 2022

Zoledronic acid (ZOL) inhibits receptor activator of nuclear factor-κB ligand (RANKL) and reduces bone turnover. This plays an important role in the development of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Previous reports have shown that ZOL binds to the enzyme farnesyl pyrophosphate synthase (FPPS) to block its activity. However, the mechanism of action of ZOL and its interaction with RANKL is still unclear. In this study, we confirmed that ZOL significantly suppressed the bone remodeling in ZOL-treated rats, investigated whether ZOL could bind to RANKL and examined the interactions between these molecules at the atomic level. Surface plasmon resonance (SPR) assay was performed to validate that ZOL could directly bind to RANKL in a dose dependent manner, and the equilibrium constant was calculated (KD= 2.28 × 10−4 M). Then, we used molecular docking simulation to predict the binding site and analyze the binding characteristics of ZOL and RANKL. Through molecular dynamics simulation, we confirmed the stable binding between ZOL and RANKL and observed their dynamic interactions over time. Binding free energy calculations and its decomposition were conducted to obtain the binding free energy −70.67 ± 2.62 kJ/mol for the RANKL–ZOL complex. We identified the key residues of RANKL in the binding region, and these included Tyr217(A), Val277(A), Gly278(A), Val277(B), Gly278(B), and Tyr215(C). Taken together, our results demonstrated the direct interaction between ZOL and RANKL, indicating that the pharmacological action of ZOL might be closely related to RANKL. The design of novel small molecules targeting RANKL might reduce the occurrence of BRONJ.
Function-Wise Dual-Omics analysis for radiation pneumonitis prediction in lung cancer patients
Authors: Li Bing , Ren Ge , Guo Wei , Zhang Jiang , Lam Sai-Kit , Zheng Xiaoli , Teng Xinzhi , Wang Yunhan , Yang Yang , Dan Qinfu , Meng Lingguang , Ma Zongrui , Cheng Chen , Tao Hongyan , Lei Hongchang , Cai Jing , Ge Hong 
Published: September 2022

Purpose: This study investigates the impact of lung function on radiation pneumonitis prediction using a dual-omics analysis method.Methods: We retrospectively collected data of 126 stage III lung cancer patients treated with chemo-radiotherapy using intensity-modulated radiotherapy, including pre-treatment planning CT images, radiotherapy dose distribution, and contours of organs and structures. Lung perfusion functional images were generated using a previously developed deep learning method. The whole lung (WL) volume was divided into function-wise lung (FWL) regions based on the lung perfusion functional images. A total of 5,474 radiomics features and 213 dose features (including dosiomics features and dose-volume histogram factors) were extracted from the FWL and WL regions, respectively. The radiomics features (R), dose features (D), and combined dual-omics features (RD) were used for the analysis in each lung region of WL and FWL, labeled as WL-R, WL-D, WL-RD, FWL-R, FWL-D, and FWL-RD. The feature selection was carried out using ANOVA, followed by a statistical F-test and Pearson correlation test. Thirty times train-test splits were used to evaluate the predictability of each group. The overall average area under the receiver operating characteristic curve (AUC), accuracy, precision, recall, and f1-score were calculated to assess the performance of each group.Results: The FWL-RD achieved a significantly higher average AUC than the WL-RD group in the training (FWL-RD: 0.927 ± 0.031, WL-RD: 0.849 ± 0.064) and testing cohorts (FWL-RD: 0.885 ± 0.028, WL-RD: 0.762 ± 0.053, p &lt; 0.001). When using radiomics features only, the FWL-R group yielded a better classification result than the model trained with WL-R features in the training (FWL-R: 0.919 ± 0.036, WL-R: 0.820 ± 0.052) and testing cohorts (FWL-R: 0.862 ± 0.028, WL-R: 0.750 ± 0.057, p &lt; 0.001). The FWL-D group obtained an average AUC of 0.782 ± 0.032, obtaining a better classification performance than the WL-D feature-based model of 0.740 ± 0.028 in the training cohort, while no significant difference was observed in the testing cohort (FWL-D: 0.725 ± 0.064, WL-D: 0.710 ± 0.068, p = 0.54).Conclusion: The dual-omics features from different lung functional regions can improve the prediction of radiation pneumonitis for lung cancer patients under IMRT treatment. This function-wise dual-omics analysis method holds great promise to improve the prediction of radiation pneumonitis for lung cancer patients.
Metabolomics study of treatment response to conbercept of patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy
Authors: Shen Yinchen , Wang Hanying , Xu Xiaoyin , Chen Chong , Zhu Shaopin , Cheng Lu , Fang Junwei , Liu Kun , Xu Xun 
Published: September 2022

Background: Neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) are major causes of blindness in aged people. 30% of the patients show unsatisfactory response to anti-vascular endothelial growth factor (anti-VEGF) drugs. This study aims to investigate the relationship between serum metabolome and treatment response to anti-VEGF therapy.Methods: A prospective longitudinal study was conducted between March 2017 and April 2019 in 13 clinical sites in China. The discovery group were enrolled from Shanghai General Hospital. The validation group consisted of patients from the other 12 sites. Participants received at least one intravitreal injection of 0.5 mg anti-VEGF drug, conbercept, and were divided into two groups - responders and non-responders. Serum samples of both groups were processed for UHPLC-MS/MS analysis. We constructed principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) models to investigate the metabolic differences between two groups using SIMCA-P. Area under curve (AUC) was calculated to screen the biomarkers to predict treatment response. Metabolites sub-classes and enriched pathways were obtained using MetaboAnalyst5.0.Results: 219 eyes from 219 patients (nAMD = 126; PCV = 93) were enrolled. A total of 248 metabolites were detected. PCA and PLS-DA models of the discovery group demonstrated that the metabolic profiles of responders and non-responders clearly differed. Eighty-five differential metabolites were identified, including sub-classes of diacylglycerophosphocholines, lysophosphatidylcholine (LPC), fatty acids, phosphocholine, etc. Responders and non-responders differed most significantly in metabolism of LPC (p = 7.16 × 10^-19) and diacylglycerophosphocholine (p = 6.96 × 10^-17). LPC 18:0 exhibited the highest AUC, which is 0.896 with 95% confidence internal between 0.833 and 0.949, to discriminate responders. The predictive accuracy of LPC 18:0 was 72.4% in the validation group.Conclusions: This study suggests that differential metabolites may be useful for guiding treatment options for nAMD and PCV. Metabolism of LPC and diacylglycerophosphocholine were found to affect response to conbercept treatment. LPC 18:0 was a potential biomarker to discriminate responders from non-responders.
The R-S difference index: A new electrocardiographic method for differentiating idiopathic premature ventricular contractions originating from the left and right ventricular outflow tracts presenting a left bundle branch block pattern
Authors: Zhao Lei , Li Ruibin , Zhang Jidong , Xie Ruiqin , Lu Jingchao , Liu Jinming , Miao Chenglong , Cui Wei 
Published: September 2022

Introduction: Differentiating idiopathic premature ventricular contractions (PVCs) originating from the right and left ventricular outflow tracts with a left bundle branch block (LBBB) morphology is relevant to catheter ablation planning and important for lowering the risk of complications. This study established a novel electrocardiographic (ECG) criterion to discriminate PVCs originating from the septum of the right ventricular outflow tract (s-RVOT) and those originating from the aortic sinus cusp of the left ventricular outflow tract (LVOT-ASC).Methods: A total of 259 patients with idiopathic PVCs originating from ventricular outflow tract with a LBBB pattern who underwent successful catheter ablation were retrospectively included. Among them, the PVCs originated from the s-RVOT in 183 patients and from the LVOT-ASC in 76 patients. The surface ECGs of the PVCs and sinus beats were analyzed using an electronic caliper. The R-S difference index in the precordial leads was calculated as V2R + V3R + V4R − V1S.Results: PVCs originating from both the s-RVOT and LVOT-ASC displayed an inferior axis (dominant R waves in leads II, III, and aVF). Compared with the s-RVOT group, the R-wave amplitudes on leads II, III, and aVF were significantly larger in the LVOT-ASC group (p &lt; 0.001, p &lt; 0.003, and p &lt; 0.001, respectively). Compared to the LVOT-ASC group, the s-RVOT group showed smaller R-wave amplitudes on leads V1–V6 (p = 0.021, p &lt; 0.001, p &lt; 0.001, p &lt; 0.001, p &lt; 0.001, and p &lt; 0.001, respectively) and larger S-wave amplitudes on leads V1–V3 (p &lt; 0.001, p &lt; 0.001, and p &lt; 0.001, respectively). Lead V3 was the most common transitional lead in both groups. Analysis of the receiver operating characteristic curve showed that the R-wave amplitude on lead V3 had the largest area under the curve (AUC) of 0.856 followed by the R-wave amplitudes on leads V4 (0.834) and V2 (0.806). The AUC of the R-S difference index was 0.867. An R-S difference index greater than 20.9 predicted an LVOT-ASC origin with 73.7% sensitivity and 86.3% specificity. This index is superior to previous criteria in differentiating PVCs with LBBB morphology and inferior axis originating from s-RVOT vs. LVOT-ASC.Conclusions: The R-S difference index in precordial leads is a useful new ECG criterion for distinguishing LVOT-PVCs from RVOT-PVCs with LBBB morphology.
Can the systemic inflammation score be used to predict prognosis in gastric cancer patients undergoing surgery? A systematic review and meta-analysis
Authors: Liu Shuai , Yu Xiaowei , Ye Feifei , Jiang Liangxian 
Published: September 2022

BackgroundInflammatory markers are being increasingly used to predict the prognosis of cancer patients. We hereby conducted the first meta-analysis assessing the association between systemic inflammation score (SIS) and prognosis of gastric cancer patients undergoing surgical intervention.MethodsA literature search was carried out on PubMed, CENTRAL, Scopus, and Embase up to 3rd June 2022 for relevant studies. Adjusted data reported as hazard ratios (HR) was combined in a random-effects model.ResultsA total of seven studies with 5,338 patients could be included. All studies were from either China or Japan and published in the last four years. Meta-analysis showed that higher SIS scores (1 or 2) were significant predictors of poor overall survival (OS) in gastric cancer patients (HR: 1.25 95% CI: 1.05, 1.49, I2 = 11%). Similarly, the meta-analysis demonstrated that an SIS score of 2 was associated with poor OS as compared to scores of 0/1 (HR: 2.53 95% CI: 1.30, 4.89, I2 = 45%). Data on disease-free survival (DFS) was scarce to draw conclusions.ConclusionThe SIS score can be a simple and useful tool to predict OS in gastric cancer patients undergoing surgery. Data on DFS is scarce and conflicting. Future studies should report using standard reference groups and provide data on DFS to enhance current evidence.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/#searchadvanced, identifier: CRD42022335548.
PHYSICAL PROCESSES IN ELECTROSTATIC MOLDING OF FIBER-REINFORCED CONCRETE PRODUCTS
Authors: Нахаев М. Р. , Аласханов А. Х. 
Published: September 2022

На производство одной тонны цемента расходуется в разных странах от 700 до 1100 кВт·ч энергии. Добыча миллионов тонн сырья и работа цементных заводов сопровождается вредными выбросами, которые наносят большой ущерб окружающей среде. Поэтому разработка новых энерго- и ресурсосберегающих строительных технологий особенно важна. Для экономии цемента в строительстве разработана новая технология. Предлагается метод послойного электростатического нанесения сухих порошковых компонентов бетонной смеси и волокон на формообразующий арматурно-сеточный каркас изделия. Нанесенные слои периодически увлажняют тонкораспыленной водой. Процесс повторяют до получения фибробетона нужной толщины. В новой технологии водоцементное отношение может быть равным теоретической величине для данного состава бетона. Это должно давать экономию цемента без снижения прочности фибробетона. Необходимо учитывать особенности, диктуемые электростатической технологией. Например, в узкие и глубокие каналы электрическое поле почти не проникает. Рассматриваются электрофизические особенности метода. Например, за какое время происходит зарядка частиц сухой бетонной смеси. От чего зависит производительность процесса нанесения покрытия, какова оптимальная скорость воздушного потока из электростатического распылителя и др.
The production of cement in different countries is consuming 700-1100 kWh of energy per 1 ton. The extraction of millions of tons of raw materials and the operation of cement plants are accompanied by harmful emissions that cause great harm to the environment. Therefore, the development of energy and resource saving new building technologies is especially important. A new technology has been developed to save cement in construction. A method of layer-by-layer electrostatic deposition of dry powder components of a concrete mixture and fibers on the forming reinforcing-mesh frame of the product is proposed. The applied layers are periodically moistened with water mist. The process is repeated until the desired thickness of fiber-reinforced concrete is obtained. With the new technology, the water-cement ratio can be equal to the theoretical value for a given concrete composition. This should result in cement savings without compromising the strength of the fiber-reinforced concrete. It is necessary to account for the issues associated with the electrostatic technology. For instance, the electric field hardly propagates into narrow and deep channels. The electrophysical features of the method are considered. For example, how long does it take to charge particles of a dry concrete mixture? What determines the productivity of the coating process, what is the optimal air flow rate from an electrostatic spray gun, etc.
REMOTE TEMPERATURE METER WITH IMPROVED CHARACTERISTICS FOR AUTOMATED CONTROL SYSTEM OF A TECHNOLOGICAL PROCESS
Authors: Хасцаев Б. Д. , Хмара В. В. , Аликов А. Ю. , Марсов В. И. , Суворов Д. М. 
Published: September 2022

В работе ставится задача разработки дистанционного измерителя температуры с высокими метрологическими характеристиками, обеспечивающего повышение эффективности современных АСУ ТП. Предложена структурная схема такого устройства, которая состоит из двух составляющих. Первая представляет собой измерительный преобразователь с датчиком температуры, построенная на основе моста Уитстона с линеаризованной выходной характеристикой. В устройстве возможно применение любого термометра сопротивления в качестве датчика температуры, к примеру, платиновый датчик температуры. Отличительной особенностью дистанционного измерителя температуры является включение датчика температуры по четырехпроводной схеме включения для обеспечения высокой точности измерения температуры и обеспечение дистанционной передачи данных измерения. Вторая составляющая дистанционного измерителя температуры представляет собой схему сбора, обработки и передачи результатов измерения температуры на расстояние, построенная на основе масштабного усилителя, АЦП, микроконтроллера и блока дистанционной передачи данных.
The article sets the task of developing a remote temperature meter with high metrological characteristics, providing an increase in the efficiency of modern automated control systems of technological process. A block diagram of such a device is proposed, it consists of two components. The first is a temperature transmitter based on a Wheatstone bridge with a linearized output characteristic. The device can use any resistance thermometer as a temperature sensor, for example, a platinum temperature sensor. A distinctive feature of the remote temperature meter is the inclusion of a temperature sensor in a four-wire connection circuit to ensure high accuracy of temperature measurement and ensure remote transmission of measurement data. The second component of the remote temperature meter is a circuit for collecting, processing and transmitting temperature measurement results over a distance, built on the basis of a scale amplifier, an ADC, a microcontroller and a remote data transmission unit.
CORPORATE VENTURE FUNDS AS A TOOL FOR THE FORMATION OF AN ENTERPRISE INNOVATION SYSTEM
Authors: Тавбулатова З. К. , Сулумов И. О. 
Published: September 2022

В статье исследуется процесс разработки радикальных инноваций, выявляются значимые отличия этого процесса в малых и крупных предприятиях. Цель статьи состоит в определении ключевых характеристик инновационной системы организаций, способной систематически воплощать радикальные инновационные проекты на нынешнем этапе развития сферы инноваций. По результатам исследования отмечена возрастающая роль малых предприятий в воплощении радикальных проектов. Также определено, что сетевой принцип управления проектами оптимален для радикальной инновационной деятельности.
The article investigates the process of development of radical innovations, reveals significant differences of this process between small and large enterprises. The aim of the article is to determine the key characteristics of the innovation system of organizations that are able to systematically implement radical innovation projects. According to the results of the research the increasing role of small enterprises in the implementation of radical projects has been noted. Also we have determined that the network principle of project management is optimal for radical innovations.
THE ROLE OF MODERN GAMING TECHNOLOGIES IN EDUCATION
Authors: Бапаева Х. М. 
Published: September 2022

Образовательная система на современном этапе сталкивается с серьезными проблемами, связанными с мотивацией и вовлечением обучающихся. Геймификация - включение игровых элементов в неигровые условия обучения - предоставляет широкие возможности решать эти проблемы. Текущий обзор роста популярности технологий геймификации и не вызывающий сомнения успех ее применения в образовательном контексте направлен на более реалистичный подход исследования в этой области. В данной статье сосредоточено внимание на аналитику эмпирических данных, а не на возможности, убеждения или предпочтения. Результаты, полученные в данных исследованиях, интерпретируются для конкретных комбинаций игровых элементов, геймифицированной деятельности в рамках учебного предмета и возрастной группы.
The educational system at the present stage faces serious problems related to the motivation and involvement of students. Gamification - the inclusion of game elements in non-game learning environments - provides ample opportunities to solve these problems. The current review of the rise in popularity of gamification technologies and the undeniable success of its application in an educational context is aimed at a more realistic research approach in this area. This article focuses on empirical data analytics rather than capabilities, beliefs, or preferences. The results obtained in these studies are interpreted for specific combinations of game elements, gamified activities within the academic subject and age group.
Degree of Organizational Justice among Principals at Al-Qweismeh Primary Schools and its Relationship to Teachers’ Loyalty
Authors: Alabsi Ayah Thiab 
Published: September 2022

Objectives: This study aims to identify the degree of practice of organizational justice among public primary school principals in Qweismeh District and its relationship to loyalty of teachers to those schools. The study was applied to a sample of (288) male and female teachers who were chosen by a stratified random method.
Methods: The researcher developed a questionnaire for organizational justice, and another for organizational loyalty. The validity and reliability of the two questionnaires were verified.
Results: One of the most prominent results reveal that the degree of practicing organizational justice among the principals of public primary schools in Al-Qweismeh district and the degree of organizational loyalty among the teachers in those schools were medium. The results also show a positive, direct, statistically significant correlation between the degree of practice of organizational justice among principals of public primary schools in Al-Qweismeh district and the organizational loyalty of teachers in those schools. The results also show that there were statistically significant differences in the degree of practice of organizational justice among school principals due to gender in favor of females, while there were no statistically significant differences due to experience.
Conclusions: The researcher recommends that teachers should be given an opportunity to participate more in school work, and to reduce the burden of paperwork placed on the teachers.