bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outpatient cardiac rehabilitation dose after acute coronary syndrome in a nationwide cohort
Authors: Kanaoka Koshiro , Iwanaga Yoshitaka , Nakai Michikazu , Nishioka Yuichi , Myojin Tomoya , Kubo Shinichiro , Okada Katsuki , Soeda Tsunenari , Noda Tatsuya , Sakata Yasushi , Miyamoto Yoshihiro , Saito Yoshihiko , Imamura Tomoaki 
Published: March 2022

ObjectiveCardiac rehabilitation (CR) is effective in patients with acute coronary syndrome (ACS); however, CR programmes have not been fully implemented. This study aimed to reveal the current practice of outpatient CR and the dose–effect relationship of CR in real-world settings.MethodsWe performed a nationwide retrospective cohort study using the National Database of Health Insurance Claims and Specific Health Checkups of Japan. Patients with ACS who underwent percutaneous coronary intervention between April 2014 and March 2018 were included. We analysed the implementation rate and dose of outpatient CR and the association between dose and outcomes.ResultsOut of 202 320 patients who underwent percutaneous coronary intervention for ACS, a total of 20 444 (10%) underwent outpatient CR. The median (IQR) number of total CR sessions was 9 (3–17), and the median (IQR) duration for each session was 60 (42–60) min. Patients were divided into four groups according to the total number of sessions (≤9 times or ≥10 times) and the duration per session (<50 min or ≥50 min). Compared with the low-number/short-duration group, the adjusted HR for all-cause mortality was 1.00 (95% CI 0.80 to 1.24, p=0.97) in the low-number/long-duration group, 0.63 (95% CI 0.46 to 0.87, p=0.005) in the high-number/short-duration group and 0.74 (95% CI 0.60 to 0.92, p=0.008) in the high-number/long-duration group, respectively.ConclusionWe found that the participation rate for outpatient CR after ACS was low and the doses of sessions vary in real-world settings. A higher number of total sessions of outpatient CR is associated with a better prognosis irrespective of the session’s duration.
Carotid artery endarterectomy in patients with symptomatic non-stenotic carotid artery disease
Authors: Nardi Valentina , Benson John C , Larson Anthony S , Brinjikji Waleed , Saba Luca , Meyer Fredric B , Lanzino Giuseppe , Lerman Amir , Savastano Luis E 
Published: March 2022

ObjectWe sought to determine the safety and efficacy in secondary stroke prevention of carotid endarterectomy (CEA) in patients with symptomatic non-stenotic carotid artery disease (SyNC).MethodsThis was a single-centre retrospective case series. All patients who underwent CEA for unilateral anterior circulation cerebrovascular events with ipsilateral <50% carotid stenosis from 2002 to 2020 were included. Imaging hallmarks including the degree of luminal stenosis and the presence of various vulnerable plaque characteristics (eg, intraplaque haemorrhage (IPH) on MR angiography, ulceration or low-density plaque on CT angiography) were assessed. The presence of vulnerable plaque characteristics was compared between arteries ipsilateral to the ischaemic event and contralateral arteries. The prevalence of perioperative/intraoperative complications, as well as recurrent ischaemic events at follow-up was determined.ResultsThirty-two patients were included in the analysis, of which 25.0% were female. Carotid arteries ipsilateral to an ischaemic event had a significantly higher prevalence of IPH when compared with contralateral arteries (80.0% vs 0.0%; p<0.001). There were no intraoperative complications. One patient (3.1%) developed symptoms of transient ipsilateral ischaemia 1 day following CEA which resolved without treatment. In a median follow-up of 18.0 months (IQR 5.0–36.0), only one patient (3.1%) experienced a transient neurologic deficit with complete resolution (annualised rate of recurrent stroke after CEA of 1.5% for a total follow-up of 788 patient-months following CEA). All other patients (31/32, 96.9%) were free of recurrent ischaemic events.ConclusionCEA appears to be safe and well-tolerated in patients with SyNC. Additional studies with larger cohorts and longer follow-up intervals are needed in order to determine the role of CEA in this patient population.
Clinical and radiological features of medullary infarction caused by spontaneous vertebral artery dissection
Authors: Yu Chun , Zhu Zhu , Li Siying , Xu Yi , Yan Wei , Kang Xiaocui , Li Yao , Dong Qiang , Tang Weijun , Han Xiang 
Published: March 2022

Background and purposeMedullary infarction (MI) caused by spontaneous vertebral artery dissection (sVAD) is an important type of stroke. It is important to distinguish sVAD from other causes of stroke since the treatment strategies and prognosis were different between them. In this study, we aimed to explore the clinical and radiological features of MI in patients with acute MI caused by sVAD.MethodsPatients with acute MI caused by sVAD and non-sVAD in a single tertiary hospital were enrolled from 2010 to 2020. Epidemiologic, clinical and image features were collected and analysed. MI lesions were categorised into three levels rostrocaudally and four arterial groups: anteromedial, anterolateral, lateral and posterior.ResultsA total of 128 patients with MI were enrolled with 47 cases of sVAD and 81 cases of non-sVAD. Patients with sVAD were younger than those with non-sVAD (med 44 years old vs 58 years old). The sVAD group was less likely to have hypertension (44.68% vs 67.90%; p=0.010) and diabetes (19.15% vs 45.69%; p=0.003), but more likely to have non-sudden onset (27.66% vs 9.87%, p=0.009), minor neck injury (19.15% vs 1.23%; p=0.001) and headache (46.81% vs 7.41%; p=0.000). Vertically, sVAD became more common in caudal medulla than in rostral medulla. Horizontally, the sVAD group was more likely to have lateral MI (91.48% vs 2.96%, p=0.000). In multivariable logistic regression analysis, age, non-sudden onset and headache were independently associated with sVAD with ORs of 0.935 (95% CI 0.892 to 0.981, p=0.006), 3.507 (95% CI 1.060 to 11.599, p=0.040) and 5.426 (95% CI 1.673 to 17.599, p=0.005).ConclusionsVAD was not uncommon in patients with MI, especially in patients with lateral MI. Young patients with headache and non-sudden onset should remind clinician the possibility of sVAD.
Illicit trade in tobacco products: recent trends and coming challenges
Authors: Paraje Guillermo , Stoklosa Michal , Blecher Evan 
Published: March 2022

BackgroundIllicit trade in tobacco products is a menace to the goal of eliminating tobacco consumption. Although tax policy is very effective in reducing consumption, illicit trade can reduce (though not eliminate) its effectiveness.MethodsThis article discusses the recent evolution of illicit trade and the context in which it occurred; the new methods that have been developed to measure it and, finally, the challenges in the next phase in the control of illicit trade.ResultsThere has been a remarkable stability in the penetration of cigarette illicit trade in the past decade. Such a stability, however, occurred in a world of shrinking tobacco consumption, implying a decreasing absolute illicit trade. Most countries have progressed in increasing tobacco taxes and changing tax structures. Prices of illicit cigarettes follow legal cigarette prices. Concomitantly, many new studies, independent from the tobacco industry, have been conducted allowing for better understanding of the illicit trade and providing inputs to its solution. The entry into force of the WHO FCTC Protocol to Eliminate Illicit Trade in Tobacco Products provides both a global and a national policy framework to further curb illicit trade. Instruments such as track-and-trace systems must be promoted and adopted to maximise reductions in illicit trade.ConclusionsGlobal efforts to curb the illicit trade in tobacco products are gaining momentum and progress has been made in many parts of the world. The next decade can witness a decisive decrease in tobacco consumption, both licit and illicit, if countries further engage in international collaboration.
On angular features of axial channeling radiation in crystals
Authors: Korotchenko K. B. , Kunashenko Y. P. , Dabagov S. B. 
Published: March 2022

AbstractChanneling of light relativistic particles in crystals is accompanied by intense radiation emission known as channeling radiation. Typically all calculations of channeling radiation aim in getting the total radiation intensity and its dependence on the parameters of particles and crystals. In the same time, since the discovery, the angular behaviours of channeling radiation have been studied just in a few works, in which only a polar dependence of the radiation intensity near the forward direction is estimated. However, simple analysis of the interaction potential predicts very specific features to be observed in the angular distributions of channeling radiation, especially at axial regime. In this work, for the first time, the expressions for angular and spectral distributions of electromagnetic radiation at axial channeling of relativistic charged particles in thin crystals are analytically refined within the QED theory. Obtained results allows predicting complex structures of radiation intensity and polarisation distributions. The results obtained might be of special interests for experimental studies.
Impact of igneous intrusion and associated ground deformation on the stratigraphic record
Authors: Dobb Emilia M. , Magee Craig , Jackson Christopher A.-L. , Lathrop Bailey , Köpping Jonas 
Published: March 2022

Abstract
The geomorphology and sediment systems of volcanic areas can be influenced by uplift (forced folding) related to subsurface migration and accumulation of magma. Seismic geomorphological analysis presents a unique tool to study how surface morphology and subsurface magma dynamics relate, given seismic reflection data can image buried landscapes and underlying intrusions in 3D at resolutions of only a few metres–decametres. However, differential compaction of the sedimentary sequence above incompressible igneous intrusions during burial modifies palaeosurface morphology. Here we use 3D seismic reflection data from offshore NW Australia to explore how the stratigraphic record of igneous intrusion and associated ground deformation can be unravelled. We focus on a forced fold that likely formed in the Early Cretaceous to accommodate intrusion of magma, but which was later amplified by burial-related differential compaction of the host sedimentary sequence. We show how: (1) marine channels and clinoforms may be deflected by syn-depositional intrusion-induced forced folds; and (2) differential compaction can locally change clinoforms depth post-deposition, potentially leading to erroneous interpretation of shoreline trajectories. Our results demonstrate seismic geomorphological analysis can help us better understand how magma emplacement translates into ground deformation, and how this shapes the landform of volcanic regions.
General Strong Polarization
Authors: Błasiok Jarosław , Guruswami Venkatesan , Nakkiran Preetum , Rudra Atri , Sudan Madhu 
Published: March 2022

Arıkan’s exciting discovery of polar codes has provided an altogether new way to efficiently achieve Shannon capacity. Given a (constant-sized) invertible matrix
M
, a family of polar codes can be associated with this matrix and its ability to approach capacity follows from the
polarization
of an associated [0, 1]-bounded martingale, namely its convergence in the limit to either 0 or 1 with probability 1. Arıkan showed appropriate polarization of the martingale associated with the matrix (
G
2
= ( 1 1 0 1) to get capacity achieving codes. His analysis was later extended to all matrices
M
that satisfy an obvious necessary condition for polarization.

While Arıkan’s theorem does not guarantee that the codes achieve capacity at small blocklengths (specifically in length, which is a polynomial in ( 1ε ) where (ε) is the difference between the capacity of a channel and the rate of the code), it turns out that a “strong” analysis of the polarization of the underlying martingale would lead to such constructions. Indeed for the martingale associated with (
G
2
) such a strong polarization was shown in two independent works (Guruswami and Xia (IEEE IT’15) and Hassani et al. (IEEE IT’14)), thereby resolving a major theoretical challenge associated with the efficient attainment of Shannon capacity.

In this work we extend the result above to cover martingales associated with all matrices that satisfy the necessary condition for (weak) polarization. In addition to being vastly more general, our proofs of strong polarization are (in our view) also much simpler and modular. Key to our proof is a notion of
local polarization
that only depends on the evolution of the martingale in a single time step. We show that local polarization always implies strong polarization. We then apply relatively simple reasoning about conditional entropies to prove local polarization in very general settings. Specifically, our result shows strong polarization over all prime fields and leads to efficient capacity-achieving source codes for compressing arbitrary i.i.d. sources, and capacity-achieving channel codes for arbitrary symmetric memoryless channels. We show how to use our analyses to achieve exponentially small error probabilities at lengths inverse polynomial in the gap to capacity. Indeed we show that we can essentially match any error probability while maintaining lengths that are only inverse polynomial in the gap to capacity.
Novel Role of Prereplication Complex Component Cell Division Cycle 6 in Retinal Neovascularization
Authors: Kumar Raj , Rao Gadiparthi N. 
Published: March 2022

Background:
The major aim of this study is to investigate whether CDC6 (cell division cycle 6), a replication origin recognition complex component, plays a role in retinal neovascularization, and if so, to explore the underlying mechanisms.

Methods:
In this study, we used a variety of approaches including cellular and moleculer biological methodologies as well as global and tissue-specific knockout mice in combination with an oxygen-induced retinopathy model to study the role of CDC6 in retinal neovascularization.

Results:
VEGFA (vascular endothelial growth factor A)-induced CDC6 expression in a time-dependent manner in human retinal microvascular endothelial cells. In addition, VEGFA-induced CDC6 expression was dependent on PLCβ3 (phospholipase Cβ3)-mediated NFATc1 (nuclear factor of activated T cells c1) activation. Furthermore, while siRNA-mediated depletion of PLCβ3, NFATc1, or CDC6 levels blunted VEGFA-induced human retinal microvascular endothelial cell angiogenic events such as proliferation, migration, sprouting, and tube formation, CDC6 overexpression rescued these effects in NFATc1-deficient mouse retinal microvascular endothelial cells. In accordance with these observations, global knockdown of PLCβ3 or endothelial cell–specific deletion of NFATc1 or siRNA-mediated depletion of CDC6 levels substantially inhibited oxygen-induced retinopathy–induced retinal sprouting and neovascularization. In addition, retroviral-mediated overexpression of CDC6 rescued oxygen-induced retinopathy–induced retinal neovascularization from inhibition in PLCβ3 knockout mice and in endothelial cell–specific NFATc1-deficient mice.

Conclusions:
The above observations clearly reveal that PLCβ3-mediated NFATc1 activation-dependent CDC6 expression plays a crucial role in VEGFA/oxygen-induced retinopathy-induced retinal neovascularization.
Early Clinical Experience With the TRICENTO Bicaval Valved Stent for Treatment of Symptomatic Severe Tricuspid Regurgitation: A Multicenter Registry
Authors: Wild Mirjam G. , Lubos Edith , Cruz-Gonzalez Ignacio , Amat-Santos Ignacio , Ancona Marco , Andreas Martin , Boeder Niklas F. , Butter Christian , Carrasco-Chinchilla Fernando , Estevez-Loureiro Rodrigo , Kempfert Jörg , Köll Benedikt , Montorfano Matteo , Nef Holger M. , Toggweiler Stefan , Unbehaun Axel , Werner Paul , Windecker Stephan , Praz Fabien 
Published: March 2022

Background:
Patients with severe tricuspid regurgitation present late and are often ineligible for surgery or transcatheter repair systems. Transfemoral venous implantation of a bicaval valved stent has been proposed as therapeutic option in selected patients. The aim of this study was to summarize the early procedural and clinical outcomes of the novel TRICENTO system for the treatment of patients with symptomatic severe tricuspid regurgitation.

Methods:
All consecutive patients treated with the custom-made TRICENTO implant at the participating centers were included in this retrospective multicentre registry.

Results:

A total of 21 high-risk patients (mean age 76±7 years; 67% female) with severe or higher grade tricuspid regurgitation were analyzed. The majority of the patients were in New York Heart Association class III/IV (95%), had peripheral edema (95%), and previous hospitalization for right heart failure (67%). Technical success was 100%, and there was no case of in-hospital mortality. During follow-up (median 61 days), symptomatic improvement was observed (65% in New York Heart Association class I/II;
P
<0.001). Computed tomography revealed asymptomatic fractures of the TRICENTO prosthesis in 3 patients. Cardiac magnetic resonance imaging obtained in 7 patients showed a significant decrease (252±65 mm
3
at baseline versus 216±58 mm
3
at follow-up,
P
=0.006) of right ventricular end-diastolic volume. The overall-survival rate was 76% at 1 year.

Conclusions:
The present data indicate the feasibility of transfemoral bicaval valved stent implantation for the treatment of severe tricuspid regurgitation. Functional improvement and signs of right ventricular reverse remodeling were observed. Stent fractures did not impair valve function, but require refinement of prosthesis design and careful assessment of eligibility criteria.
Heteroplasmy of Wild-Type Mitochondrial DNA Variants in Mice Causes Metabolic Heart Disease With Pulmonary Hypertension and Frailty
Authors: Lechuga-Vieco Ana Victoria , Latorre-Pellicer Ana , Calvo Enrique , Torroja Carlos , Pellico Juan , Acín-Pérez Rebeca , García-Gil María Luisa , Santos Arnoldo , Bagwan Navratan , Bonzon-Kulichenko Elena , Magni Ricardo , Benito Marina , Justo-Méndez Raquel , Simon Anna Katharina , Sánchez-Cabo Fátima , Vázquez Jesús , Ruíz-Cabello Jesús , Enríquez José Antonio 
Published: March 2022

Background:
In most eukaryotic cells, the mitochondrial DNA (mtDNA) is transmitted uniparentally and present in multiple copies derived from the clonal expansion of maternally inherited mtDNA. All copies are therefore near-identical, or homoplasmic. The presence of >1 mtDNA variant in the same cytoplasm can arise naturally or result from new medical technologies aimed at preventing mitochondrial genetic diseases and improving fertility. The latter is called divergent nonpathologic mtDNA heteroplasmy (DNPH). We hypothesized that DNPH is maladaptive and usually prevented by the cell.

Methods:
We engineered and characterized DNPH mice throughout their lifespan using transcriptomic, metabolomic, biochemical, physiologic, and phenotyping techniques. We focused on in vivo imaging techniques for noninvasive assessment of cardiac and pulmonary energy metabolism.

Results:
We show that DNPH impairs mitochondrial function, with profound consequences in critical tissues that cannot resolve heteroplasmy, particularly cardiac and skeletal muscle. Progressive metabolic stress in these tissues leads to severe pathology in adulthood, including pulmonary hypertension and heart failure, skeletal muscle wasting, frailty, and premature death. Symptom severity is strongly modulated by the nuclear context.

Conclusions:
Medical interventions that may generate DNPH should address potential incompatibilities between donor and recipient mtDNA.
The Kingdom of Peace in Luke-Acts and What Glossolalia Has to Do with It
Authors: Wenk Matthias 
Published: March 2022

Abstract
The Acts 2 narrative is central for Pentecostal identity and theology, especially with its emphasis on speaking in tongues. In Luke’s overall narrative structure, Acts 2 also plays a crucial role in defining his vision of the kingdom of God as a kingdom of peace in contrast to other kingdoms during his time. However, since the term kingdom of God (as well as peace) refers to a concept that is part of the world of ideologies (utopia), it cannot be defined without language, for its final reality, like any reality in utopias, exists at first in linguistic symbols, hence, language is foundational for any understanding of the kingdom of God, and language (glossolalia) is, so the argument, a linguistic symbol of God’s kingdom of peace that renounces any form of violence for its realization. By understanding tongues as a linguistic symbol (sacrament) of the kingdom of peace, a Pentecostal missiology will always be fully incarnational and participating in the life of the other so that they may speak their own language (for themselves). Tongues also enable the ‘missionizing group’ to withhold from any form of power (verbal, emotional, physical, or status) that impairs the dignity and identity of the other.
The Third Pentecostal Phenomenon in Indonesia
Authors: Widjaja Fransiskus Irwan , Simanjuntak Fredy , Boiliu Noh Ibrahim 
Published: March 2022

Abstract
This article examines the Holy Spirit’s outpouring phenomenon in Indonesia, named as the ‘third Pentecost’ by Indonesian Pastor Niko Njotorahardjo from Gereja Bethel Church. Njotorahardjo suggests that the first Pentecost was reported in Acts 2, the second Pentecost occurred at the Azusa Street revival, and the third Pentecost is being poured out now. This research uses discourse analysis to study discourse collected from literature, sermons, conferences, and media recordings. While the analysis of the data used in this research is descriptive, this article is expected to provide constructive input to the global church in general and to the Pentecostal–Charismatic movement in particular.
Angels and What They Could Bring
Authors: Churchouse Matt 
Published: March 2022

Abstract
Angels are endemic to the pentecostal worldview, are currently in vogue in popular spirituality, and pentecostal scholars desire for their theology to be of benefit to the pentecostal and public communities as a whole. This article contends, therefore, that scholarly pentecostal theology on the topic of angels would be of much value. It provides a scholarly contribution to the topic by first reviewing the fullest angelology proffered by a pentecostal scholar to date – that of Amos Yong. It then offers a classic-contemporary pentecostal theology and definition of angels that is more consistent with modern experiences of angels, as well as the teaching of Scripture, tradition, and reason. Finally, it commends how this angelology could be applied practically in a way that feeds the intrigue of the popular imagination, functions as a resource for apologists, and gives the interested theologian several leads for further exploration of the topic.
Moses’ Embodied Encounter
Authors: Coetzee Narelle Jane 
Published: March 2022

Abstract
This article investigates the implications of Moses’ unshod feet within the Burning Bush pericope (Exodus 3.1–4.17). Traditionally, scholars observe that the act of removing one’s shoes is merely a sign of ancient honour, conveying to Moses that he is on holy ground. Here, the author suggests, however, that through a narrative-geographical reading, additional insights can be gleaned – specifically, that Moses is being asked to participate as an embodied person, with all his senses. He is literally being ‘grounded’ in this experience, through his unshod feet. The author also argues that a larger creational relationship is implied – expressly, that Moses is the new (re)creational partner (adam), and through this bare-footed encounter is being connected back to creational purposes, via the adamah. Finally, inasmuch as Pentecostal readers of the Bible seek an ongoing experience of the Spirit, the author suggests that this narrative-geographical reading complements and re-energizes our whole-bodied spirituality and expectations of divine encounter.