bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial cluster analysis of Plasmodium vivax and P. malariae exposure using serological data among Haitian school children sampled between 2014 and 2016
Authors: Oviedo Adan , Herman Camelia , Knipes Alaine , Worrell Caitlin M. , Fox LeAnne M. , Desir Luccene , Fayette Carl , Javel Alain , Monestime Franck , Mace Kimberly E. , Chang Michelle A. , Lemoine Jean F. , Won Kimberly , Udhayakumar Venkatachalam , Rogier Eric 
Published: January 2022

Background
Estimation of malaria prevalence in very low transmission settings is difficult by even the most advanced diagnostic tests. Antibodies against malaria antigens provide an indicator of active or past exposure to these parasites. The prominent malaria species within Haiti is Plasmodium falciparum, but P. vivax and P. malariae infections are also known to be endemic.

Methodology/Principal findings
From 2014–2016, 28,681 Haitian children were enrolled in school-based serosurveys and were asked to provide a blood sample for detection of antibodies against multiple infectious diseases. IgG against the P. falciparum, P. vivax, and P. malariae merozoite surface protein 19kD subunit (MSP119) antigens was detected by a multiplex bead assay (MBA). A subset of samples was also tested for Plasmodium DNA by PCR assays, and for Plasmodium antigens by a multiplex antigen detection assay. Geospatial clustering of high seroprevalence areas for P. vivax and P. malariae antigens was assessed by both Ripley’s K-function and Kulldorff’s spatial scan statistic. Of 21,719 children enrolled in 680 schools in Haiti who provided samples to assay for IgG against PmMSP119, 278 (1.27%) were seropositive. Of 24,559 children enrolled in 788 schools providing samples for PvMSP119 serology, 113 (0.46%) were seropositive. Two significant clusters of seropositivity were identified throughout the country for P. malariae exposure, and two identified for P. vivax. No samples were found to be positive for Plasmodium DNA or antigens.

Conclusions/Significance
From school-based surveys conducted from 2014 to 2016, very few Haitian children had evidence of exposure to P. vivax or P. malariae, with no children testing positive for active infection. Spatial scan statistics identified non-overlapping areas of the country with higher seroprevalence for these two malarias. Serological data provides useful information of exposure to very low endemic malaria species in a population that is unlikely to present to clinics with symptomatic infections.
Effect of a dietary intervention including minimal and unprocessed foods, high in natural saturated fats, on the lipid profile of children, pooled evidence from randomized controlled trials and a cohort study
Authors: Hendriksen Rosanne Barbra , van der Gaag Ellen José 
Published: January 2022

Aim
To study the possible effects of a dietary intervention with minimal and unprocessed foods, high in natural saturated fats on the lipid profile and body mass index of children.

Method
This study combines three intervention studies; one non-randomized retrospective cohort study and two randomized controlled trials, to a pooled analysis. The intervention group received a dietary intervention of minimal and unprocessed foods for three to six months, consisting of five times per week green vegetables, three times per week beef, daily 200–300 mL whole cow’s milk (3.4% fat) and whole dairy butter (80% fat) on each slice of bread. The control group continued their usual dietary habits. Raw data of the three intervention studies where combined into one single dataset for data analysis, using mixed effects analysis of covariance to test the effects of the dietary advice on the main study outcomes, which are measurements of the lipid profile.

Results
In total, 267 children aged 1 to 16 years were followed. 135 children were included in the intervention group and 139 children in the control group. Characteristics (age, gender and follow-up period) were equally distributed between the groups at baseline. In the intervention group HDL-cholesterol increased significantly from 1.22 mmol/L, 95% confidence interval (CI) 1.14–1.32 to 1.42 mmol/L 95% CI 1.30–1.65 (p = 0.007). The increase over time in HDL cholesterol in the intervention group was significantly different compared to the increase in the control group (from 1.26 mmol/L, 95% CI 1.19–1.35, to 1.30 mmol/L, 95% CI 1.26–1.37) (p = 0.04). Due to the increased HDL concentration in the intervention group, the total cholesterol/HDL cholesterol ratio decreased significantly from 3.70 mmol/L, 95% CI 3.38–3.87, to 3.25 mmol/L, 95% CI 2.96–3.31 (p = 0.05).

Conclusion
Consumption of minimal and unprocessed foods (high in natural saturated fats) has favourable effects on HDL cholesterol in children. Therefore, this dietary advice can safely be recommended to children.
Evaluation of the indirect impact of the 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine in a cluster-randomised trial
Authors: Rinta-Kokko Hanna , Palmu Arto A. , Ruokokoski Esa , Nieminen Heta , Moreira Marta , Schuerman Lode , Borys Dorota , Jokinen Jukka 
Published: January 2022

Background
In the nation-wide double-blind cluster-randomised Finnish Invasive Pneumococcal disease trial (FinIP, ClinicalTrials.gov NCT00861380, NCT00839254), we assessed the indirect impact of the 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10) against five pneumococcal disease syndromes.

Methods
Children 6 weeks to 18 months received PHiD-CV10 in 48 clusters or hepatitis B/A-vaccine as control in 24 clusters according to infant 3+1/2+1 or catch-up schedules in years 2009―2011. Outcome data were collected from national health registers and included laboratory-confirmed and clinically suspected invasive pneumococcal disease (IPD), hospital-diagnosed pneumonia, tympanostomy tube placements (TTP) and outpatient antimicrobial prescriptions. Incidence rates in the unvaccinated population in years 2010―2015 were compared between PHiD-CV10 and control clusters in age groups <5 and ≥5 years (5―7 years for TTP and outpatient antimicrobial prescriptions), and in infants <3 months. PHiD-CV10 was introduced into the Finnish National Vaccination Programme (PCV-NVP) for 3-month-old infants without catch-up in 9/2010.

Results
From 2/2009 to 10/2010, 45398 children were enrolled. Vaccination coverage varied from 29 to 61% in PHiD-CV10 clusters. We detected no clear differences in the incidence rates between the unvaccinated cohorts of the treatment arms, except in single years. For example, the rates of vaccine-type IPD, non-laboratory-confirmed IPD and empyema were lower in PHiD-CV10 clusters compared to control clusters in 2012, 2015 and 2011, respectively, in the age-group ≥5 years.

Conclusions
This is the first report from a clinical trial evaluating the indirect impact of a PCV against clinical outcomes in an unvaccinated population. We did not observe consistent indirect effects in the PHiD-CV10 clusters compared to the control clusters. We consider that the sub-optimal trial vaccination coverage did not allow the development of detectable indirect effects and that the supervening PCV-NVP significantly diminished the differences in PHiD-CV10 vaccination coverage between the treatment arms.
Patients’ satisfaction with outpatient pharmacy services and associated factors in Debre Tabor comprehensive specialized hospital, Northwest Ethiopia: A cross-sectional study
Authors: Molla Mulugeta , Sisay Woretaw , Andargie Yared , Kefale Belayneh , Singh Pradeep 
Published: January 2022

Introduction
By measuring patients’ satisfaction, providers can gain insight into several elements of health care services, including the effectiveness of their care and the level of empathy they exhibit. The aim of this study was to assess patient satisfaction with pharmaceutical services and associated factors in public hospitals located in Northwestern Ethiopia.

Methods
An institution-based quantitative cross-sectional study was used. The study was carried out in an outpatient pharmacy from January 1–June 30, 2021. Participants were selected by a systematic sampling technique. The IBM SPSS statistical package (version 23) was used to enter and analyze the collected data. The findings were presented using descriptive statistical methods. To find factors linked to satisfaction, binary logistic regression was used.

Results
The final analysis included a total of 401 samples. More than half of the participants (229, or 55.1%) were female. The overall mean score of satisfaction was 30.6 out of a maximum of 100 scores. By taking this mean score as a cut-off point, 204 (50.9%) of the study participants had satisfaction with the outpatient pharmacists’ service. Participants’ responses scored on the uncomfortable and inconvenient waiting areas [AOR = 0.31; 95%CI, (0.13, 0.49)] were found to be negatively associated with the level of patients’ satisfaction. Also, the unavailability of medications [AOR = 0.12; 95%CI, (0.02, 0.37)] was negatively associated with the respondent satisfaction. Uncomfortable and inconvenient private counseling areas [AOR = 1.37; 95%CI, (0.79, 4.42)] showed a negative association with their satisfaction.

Conclusion
Patients’ satisfaction levels with pharmacy service were found to be greater than 50%. The socio-demographic characteristics of patients have no association with their level of satisfaction, but their perception of uncomfortable private counseling areas and waiting areas was negatively associated with their satisfaction.
Multidimensional impacts of coronavirus pandemic in adolescents in Pakistan: A cross sectional research
Authors: Imran Nazish , Naz Fauzia , Sharif Muhammad Imran , Liaqat Sumbul , Riaz Musarrat , Khawar Abida , Azeem Muhammad Waqar 
Published: January 2022

Background
COVID-19 has posed unique challenges for adolescents in different dimensions of their life including education, home and social life, mental and physical health. Whether the impact is positive or negative, its significance on the overall shaping of adolescents’ lives cannot be overlooked. The aim of the present study was to explore impacts of the pandemic on the adolescents’ everyday lives in Pakistan.

Methods
Following ethical approval, this cross-sectional study was conducted through September to December, 2020 via an online survey on 842 adolescents with the mean age of 17.14 ± SD 1.48. Socio-demographic data and Epidemic Pandemic Impact Inventory-Adolescent Adaptation (EPII-A) was used to assess the multi-dimensional effects of the pandemic.

Results
Among the 842 participants, 84% were girls. Education emerged as the most negatively affected Pandemic domain (41.6–64.3%). Most of the adolescents (62.0–65.8%) had reported changes in responsibilities at home including increased time spent in helping family members. Besides, increase in workload of participants and their parents was prominent (41.8% & 47.6%). Social activities were mostly halted for approximately half (41–51%) of the participants. Increased screen time, decreased physical activity and sedentary lifestyle were reported by 52.7%, 46.3% and 40.7% respectively. 22.2–62.4% of the adolescents had a direct experience with quarantine, while 15.7% experienced death of a close friend or relative. Positive changes in their lives were endorsed by 30.5–62.4% respondents. Being male and older adolescents had significant association with negative impact across most domains (p<0.05).

Conclusions
Results have shown that COVID-19 exert significant multidimensional impacts on the physical, psycho-social, and home related domains of adolescents that are certainly more than what the previous researches has suggested.
Artificial Neural Network Prediction Model of Dust Effect on Photovoltaic Performance for Residential applications: Malaysia Case Study
Authors: Ahmad Emy Zairah , Jarimi Hasila , Razak Tajul Rosli 
Published: January 2022

Dust accumulation on the photovoltaic system adversely degrades its power conversion efficiency (PCE). Focusing on residential installations, dust accumulation on PV modules installed in tropical regions may be vulnerable due to lower inclination angles and rainfall that encourage dust settlement on PV surfaces. However, most related studies in the tropics are concerned with studies in the laboratory, where dust collection is not from the actual field, and an accurate performance prediction model is impossible to obtain. This paper investigates the dust-related degradation in the PV output performance based on the developed Artificial Neural Network (ANN) predictive model. For this purpose, two identical monocrystalline modules of 120 Wp were tested and assessed under real operating conditions in Melaka, Malaysia (2.1896° N, 102.2501° E), of which one module was dust-free (clean). At the same time, the other was left uncleaned (dusty) for one month. The experimental datasets were divided into three sets: the first set was used for training and testing purposes, while the second and third, namely Data 2 and Data 3, were used for validating the proposed ANN model. The accuracy study shows that the predicted data using the ANN model and the experimentally acquired data are in good agreement, with MAE and RMSE for the cleaned PV module are as low as 1.28 °C, and 1.96 °C respectively for Data 2 and 3.93 °C and 4.92 °C respectively for Data 3. Meanwhile, the RMSE and MAE for the dusty PV module are 1.53°C and 2.82 °C respectively for Data 2 and 4.13 °C and 5.26 °C for Data 3. The ANN predictive model was then used for yield forecasting in a residential installation and found that the clean PV system provides a 7.29 % higher yield than a dusty system. The proposed ANN model is beneficial for PV system installers to assess and anticipate the impacts of dust on the PV installation in cities with similar climatic conditions.
Intention to Use Voluntary Counseling and Testing Services among College Students
Authors: Kusumaningrum Tanjung Anitasari Indah , Pratiwi Handini 
Published: January 2022

Background: HIV is a health problem of global concern. A large number of HIV cases in Surakarta is due to various factors such as the characteristics of adolescents, knowledge, attitudes, and beliefs to reduce HIV prevention through the use of VCT services. This study aims to analyze the relationship between age, gender, type of study program, information exposure, organizational participation, knowledge, attitudes, and beliefs in using VCT to use Voluntary Counseling and Testing (VCT) services for college students. Method: This research was a quantitative study with a cross-sectional approach. The study population was all students at one university in Surakarta in the 2016-2017 class as many as 12,457 students, while the research sample was 500 students who were taken using a proportional random sampling technique. Data analysis using chi-square test and logistic regression. Results: The results of the multivariate analysis showed that students' knowledge of HIV / AIDS and VCT affected the intention to use VCT services with an OR = 1.776 (CI = 1.170-2.695). The bivariate test results showed that there was a relationship between information exposure (p-value = 0.001), knowledge (p-value = 0.007), attitude (p-value = 0.006) and belief (p-value = 0.013) with the intention to use VCT services. Meanwhile, there was no relationship between age (p-value = 0.118), gender (p-value = 0.579), type of study program (p-value = 1,000), organizational participation (p-value = 0.352) with the intention of using VCT services. Students' knowledge of HIV / AIDS and VCT was the most dominant VCT intention. Therefore, providing information about VCT to students is necessary to increase students' knowledge and confidence in using VCT services.
Reproducibility of developmental neuroplasticity in in vitro brain tissue models
Authors: Salmina Alla B. , Malinovskaya Natalia A. , Morgun Andrey V. , Khilazheva Elena D. , Uspenskaya Yulia A. , Illarioshkin Sergey N. 
Published: January 2022

Abstract
The current prevalence of neurodevelopmental, neurodegenerative diseases, stroke and brain injury stimulates studies aimed to identify new molecular targets, to select the drug candidates, to complete the whole set of preclinical and clinical trials, and to implement new drugs into routine neurological practice. Establishment of protocols based on microfluidics, blood–brain barrier- or neurovascular unit-on-chip, and microphysiological systems allowed improving the barrier characteristics and analyzing the regulation of local microcirculation, angiogenesis, and neurogenesis. Reconstruction of key mechanisms of brain development and even some aspects of experience-driven brain plasticity would be helpful in the establishment of brain in vitro models with the highest degree of reliability. Activity, metabolic status and expression pattern of cells within the models can be effectively assessed with the protocols of system biology, cell imaging, and functional cell analysis. The next generation of in vitro models should demonstrate high scalability, 3D or 4D complexity, possibility to be combined with other tissues or cell types within the microphysiological systems, compatibility with bio-inks or extracellular matrix-like materials, achievement of adequate vascularization, patient-specific characteristics, and opportunity to provide high-content screening. In this review, we will focus on currently available and prospective brain tissue in vitro models suitable for experimental and preclinical studies with the special focus on models enabling 4D reconstruction of brain tissue for the assessment of brain development, brain plasticity, and drug kinetics.
LINEARIZATION OF POISSON–LIE STRUCTURES ON THE 2D EUCLIDEAN AND (1 + 1) POINCARÉ GROUPS
Authors: Ganbouri Bousselham , Mansouri Mohamed Wadia 
Published: January 2022

The paper deals with linearization problem of Poisson-Lie structures on the \((1+1)\) Poincaré and \(2D\) Euclidean groups. We construct the explicit form of linearizing coordinates of all these Poisson-Lie structures. For this, we calculate all Poisson-Lie structures on these two groups mentioned above, through the correspondence with Lie Bialgebra structures on their Lie algebras which we first determine.
SHILLA GRAPHS WITH \(b=5\) AND \(b=6\)
Authors: Makhnev Alexander A. , Belousov Ivan N. 
Published: January 2022

A \(Q\)-polynomial Shilla graph with \(b = 5\) has intersection arrays \(\{105t,4(21t+1),16(t+1); 1,4 (t+1),84t\}\), \(t\in\{3,4,19\}\). The paper proves that distance-regular graphs with these intersection arrays do not exist. Moreover, feasible intersection arrays of \(Q\)-polynomial Shilla graphs with \(b = 6\) are found.
CARLEMAN'S FORMULA OF A SOLUTIONS OF THE POISSON EQUATION IN BOUNDED DOMAIN
Authors: Sattorov Ermamat N. , Ermamatova Zuxro E. 
Published: January 2022

We suggest an explicit continuation formula for a solution to the Cauchy problem for the Poisson equation in a domain from its values and values of its normal derivative on a part of the boundary. We construct the continuation formula of this problem based on the Carleman--Yarmuhamedov function method.
A study of pre-analytical errors in the clinical biochemistry laboratory at Victoria hospital, BMCRI, Bangalore
Authors: Shanker J Sreeja , Vishwanath H L , Vibha C  , Krishna Muralidhara 
Published: January 2022

To categorize and calculate the percentage error of pre-analytical variables in the clinical biochemistry laboratory. Prospective observational study conducted for two months with documenting the frequency and type of pre-analytical errors occurring in venous samples. The total errors recorded were 1.31%. Insufficient volume followed by haemolysis amounted to a major proportion of errors. Continuous pre-analytical phase evaluation and taking corrective measures to make this phase error-free, have to be done.
A study of association of serum ferritin as a prognostic marker in acute cerebrovascular accident
Authors: B S Mythreini , M.K Uthayasankar , I.S.S Sumanbabu 
Published: January 2022

Cerebrovascular disease (CVD) is the third leading cause of death in developed countries and is now emerging as the commonest preventable life-threatening neurological problem worldwide. It makes an important contribution to morbidity and mortality in developed as well as developing countries. The prognosis of acute stroke is determined by a series of factors some of which may be used in the early stages of stroke to predict prognosis and mortality. However, the role of inflammatory markers in predicting functional outcome in stroke remains controversial, Iron and ferritin are known to have an important role in stroke as well as in other disorders. Serum ferritin which is considered as an acute phase reactant has also been used for assessing the severity and prognosis of stroke. Therefore, testing of serum ferritin is useful in identifying high risk patients.1: To study the effect of level of serum ferritin with early neurological deterioration and the outcome in patients of acute stroke. 2: Association of serum ferritin in ischemic and haemorrhagic stroke.50 patients with acute stroke were selected based on inclusion and exclusion criteria. Appropriate questionnaire was used to collect the data of patients. Diagnosis of stroke was confirmed by CT or MRI scan of brain and examination was done by Canadian stroke scale at the time of admission. About 5ml of venous blood Sample from cubital vein was collected for measuring serum ferritin levels, it was performed within 48hrs of onset of symptoms by using CLIA method. Neurological assessment was repeated on the day of discharge to assess the clinical improvement and prognosis of the stroke patients.Totally 50 patients of acute stroke were included in our study, majority of the patients are males 35 (70%), and females are 15(30%). Approximately 36% were in the age group of 51-60 years. In this study ischemic stroke was seen in 45 (90%) of the patients and 5 (10%) had hemorrhagic stroke. The serum ferritin levels are normal in 41(82%) and high in 9(18%) of the patients. Canadian stroke scale interpretation on the day of discharge showed 20% of the patient are deteriorated, 66% are in the same status and 14% of the patients are improved clinically. The patients with haemorrhagic stroke had high serum ferritin level 60.0% and ischemic stroke are 13.3%. Those patients with high serum ferritin levels had higher deterioration in Canadian stroke scale (p&#60;0.001). The mean serum ferritin levels are higher in deteriorated patients 199.29% when compared to other status group in Canadian stroke scale.High levels of serum ferritin correlates well with early neurological deterioration of stroke patients. Based on this study finding, that high serum ferritin level within 48 hours after the onset of symptoms of stroke helps to predict the early prognosis. Therefore, testing of serum ferritin is useful in identifying high risk patients.