bluuebunny/crossref_metadata_2025_split huggingface dataset:
Textural and chemical evolution of magnetite from the Paleozoic Shuanglong Fe-Cu deposit: Implications for tracing ore-forming fluids
Authors: Zhang Shuanliang , Chen Huayong , Xiao Bing , Zhao Liandang , Hu Xia , Li Jianping , Gong Lin 
Published: January 2022

Abstract
The Aqishan-Yamansu belt in Eastern Tianshan (NW China) hosts several important Fe and Fe-Cu deposits, the origin of which is the subject of considerable debate. The coexistence of various types of ore-forming fluids makes it difficult to distinguish the genesis of the Fe-Cu deposits. We present detailed textural and compositional data on magnetite from the Paleozoic Shuanglong Fe-Cu deposit to constrain the formation of iron oxides and the evolution of the ore-forming fluids and thus define the genesis of the Fe-Cu ores.
Based on the mineral assemblages and crosscutting relationships of veins, two mineralization stages were established, including the early Fe mineralization and late Cu mineralization stage. Three types of magnetite, i.e., platy (MA), massive (MB), and granular (MC) magnetite occur in the Fe mineralization. Backscattered electron (BSE) images identified display oscillatory zoning in an early hematite and transformational mushketovite phase (MA-I), characterized by abundant porosity and inclusions, as well as two later generations, including an early dark (MA-II, MB-I, and MC-I) and later light magnetite (MA-III, MB-II, and MC-II). The MA-I has extremely high W contents and mostly displays as micro- and invisible scheelite inclusions, which were probably caused by the W expulsion during mushketovitization. The texture and composition of magnetite suggest that the later light magnetite formed via dissolution and reprecipitation of the precursor dark magnetite, and the temperature and oxygen fugacity of fluids decreased over time. Our study also shows the MB-II magnetite and coexisting chlorite display synchronous oscillatory zoning, with the calculated temperature from 444 to 212 °C. Such variations could indicate the incursion of external low-temperature fluids with high salinity, which can dissolve the primary dark magnetite. This study provides a good example of using magnetite to trace the complex evolution and multiple sources of ore-forming fluids.
Performance of a Computational Phenotyping Algorithm for Sarcoidosis Using Diagnostic Codes in Electronic Medical Records: Case Validation Study From 2 Veterans Affairs Medical Centers
Authors: Seedahmed Mohamed I , Mogilnicka Izabella , Zeng Siyang , Luo Gang , Whooley Mary A , McCulloch Charles E , Koth Laura , Arjomandi Mehrdad 
Published: January 2022

Background
Electronic medical records (EMRs) offer the promise of computationally identifying sarcoidosis cases. However, the accuracy of identifying these cases in the EMR is unknown.

Objective
The aim of this study is to determine the statistical performance of using the International Classification of Diseases (ICD) diagnostic codes to identify patients with sarcoidosis in the EMR.

Methods
We used the ICD diagnostic codes to identify sarcoidosis cases by searching the EMRs of the San Francisco and Palo Alto Veterans Affairs medical centers and randomly selecting 200 patients. To improve the diagnostic accuracy of the computational algorithm in cases where histopathological data are unavailable, we developed an index of suspicion to identify cases with a high index of suspicion for sarcoidosis (confirmed and probable) based on clinical and radiographic features alone using the American Thoracic Society practice guideline. Through medical record review, we determined the positive predictive value (PPV) of diagnosing sarcoidosis by two computational methods: using ICD codes alone and using ICD codes plus the high index of suspicion.

Results
Among the 200 patients, 158 (79%) had a high index of suspicion for sarcoidosis. Of these 158 patients, 142 (89.9%) had documentation of nonnecrotizing granuloma, confirming biopsy-proven sarcoidosis. The PPV of using ICD codes alone was 79% (95% CI 78.6%-80.5%) for identifying sarcoidosis cases and 71% (95% CI 64.7%-77.3%) for identifying histopathologically confirmed sarcoidosis in the EMRs. The inclusion of the generated high index of suspicion to identify confirmed sarcoidosis cases increased the PPV significantly to 100% (95% CI 96.5%-100%). Histopathology documentation alone was 90% sensitive compared with high index of suspicion.

Conclusions
ICD codes are reasonable classifiers for identifying sarcoidosis cases within EMRs with a PPV of 79%. Using a computational algorithm to capture index of suspicion data elements could significantly improve the case-identification accuracy.
A Lifestyle Intervention to Delay Early Chronic Kidney Disease in African Americans With Diabetic Kidney Disease: Pre-Post Pilot Study
Authors: Ozieh Mukoso N , Egede Leonard E 
Published: January 2022

Background
Behavioral factors, such as lifestyle, have been shown to explain approximately 24% of the excess risk of chronic kidney disease (CKD) among African Americans. However, there are limited intervention studies culturally tailored to African Americans with type 2 diabetes mellitus and CKD.

Objective
The main objective of this study was to examine the feasibility and preliminary efficacy of a culturally tailored lifestyle intervention among African Americans with type 2 diabetes mellitus and CKD.

Methods
A pre-post design was used to test the feasibility of a lifestyle intervention in 30 African American adults recruited from the Medical University of South Carolina between January 2017 and February 2017. A research nurse delivered the manualized study intervention weekly for 6 weeks. Clinical outcomes (hemoglobin A1c, blood pressure, and estimated glomerular filtration rate [eGFR]) were measured at baseline and postintervention. Disease knowledge, self-care, and behavior outcomes were also measured using validated structured questionnaires at baseline and postintervention. Descriptive statistics and effect sizes were calculated to determine clinically important changes from baseline.

Results
Significant pre-post mean differences and decreases were observed for hemoglobin A1c (mean 0.75%, 95% CI 0.16-1.34; P=.01), total cholesterol (mean 16.38 mg/dL, 95% CI 5.82-26.94; P=.004), low-density lipoprotein (mean 13.73 mg/dL, 95% CI 3.91-23.54; P=.008), and eGFR (mean 6.73 mL/min/1.73m2, 95% CI 0.97-12.48; P=.02). Significant pre-post mean differences and increases were observed for CKD self-efficacy (mean −11.15, 95% CI −21.55 to −0.75; P=.03), CKD knowledge (mean −2.62, 95% CI −3.98 to −1.25; P<.001), exercise behavior (mean −1.21, 95% CI −1.96 to −0.46; P=.003), and blood sugar testing (mean −2.15, 95% CI −3.47 to −0.83; P=.003).

Conclusions
This study provides preliminary data for a large-scale appropriately powered randomized controlled trial to examine a culturally tailored lifestyle intervention in African Americans with type 2 diabetes mellitus and CKD in order to improve clinical, knowledge, self-care, and behavior outcomes in this population.
Ефективність та безпечність застосування фіксованої комбінації периндоприл + амлодипін у гіпертензивних пацієнтів, які лікуються амбулаторно
Authors: Sirenko Yu.N. , Radchenko A.D. 
Published: January 2022

Метою даного дослідження було оцінити можливість і безпечність застосування фіксованої комбінації (ФК) периндоприл + амлодипін як стартової терапії для лікування хворих з уперше виявленою або не­конт­рольованою попереднім лікуванням артеріальною гіпертензією (АГ) та оцінити інтенсивність лікування, призначеного лікарями загальної практики. У дослідження були включені 4424 пацієнти з різним ступенем підвищення артеріального тиску (АТ), які відповідали критеріям включення і не мали критеріїв виключення. Усі пацієнти лікувалися лікарями загальної практики амбулаторно. Середній вік хворих становив 60,0 ± 11,4 року (35,4/64,6 % — чоловіки/жінки). Всім пацієнтам проводили вимірювання офісного АТ та частоти серцевих скорочень на етапах спостереження. ФК призначалася у дозах 5/5, 10/5, 5/10 та 10/10 мг, за необхідності додавався індапамід ретард. Тривалість лікування становила 2 місяці.Призначення ФК протягом двох місяців призводило до достовірного зниження систолічного АТ (САТ) і діастолічного (ДАТ) на 34,3 та 16,1 мм рт.ст. та досягнення їх цільових рівнів у 63 % хворих. Ефективність призначеного лікування залежала від початкового рівня АТ — чим вищим він був, тим більшим був ступінь його зниження та меншою частота досягнення цільового рівня — 25,9/14,2 мм рт.ст. та 78,6 %, 37,6/16,6 мм рт ст. та 54,3 % і 56,4/21,4 мм рт.ст. та 33,7 % при початковому САТ 140–159, 160–179 та > 180 мм рт.ст. відповідно. Найбільша частота досягнення цільового рівня АТ на фоні прийому ФК була у хворих, які до цього не лікувалися, — 73,2 %, дещо меншою у тих, хто лікувався одним препаратом (від 63,8–68,2 %) та комбінацією (48,7–59 %). Дане дослідження продемонструвало існування деякої інерції серед лікарів у лікуванні хворих на АГ: незважаючи на відсутність досягнення цільового рівня АТ у половини пацієнтів не було збільшено дози компонентів ФК до максимальних та не призначався додатково третій антигіпертензивний препарат. Терапія ФК добре переносилася хворими, призводячи до виникнення побічних реакцій лише в 0,9 % хворих. Серед усіх побічних явищ найчастіше виникали кашель (0,2 %) та периферичні набряки (0,2 %). Не відмічено серйозних побічних явищ. Відміни ФК через побічні явища потребували лише 11 (0,25 %) пацієнтів. Таким чином, підтверджено антигіпертензивну ефективність та безпечність застосування ФК периндоприл + амлодипін у широкої популяції хворих з АГ та продемонстровано існування інерції серед лікарів щодо інтенсивності ведення пацієнтів з АГ та особливо з тяжкою АГ.
Діагностика артеріальної гіпертензії та експертиза профпридатності у працюючих в умовах впливу шкідливих та небезпечних факторів виробничого середовища
Authors: . . 
Published: January 2022

Основною причиною смертності в усьому світі є захворювання серцево-судинної системи (ССС). За оцінками ВООЗ, у 2008 році від серцево-судинних захворювань (ССЗ) померли 17,3 млн осіб, що становило 30 % усіх випадків смертей у світі [1]. Прогнози експертів невтішні: до 2030 року ішемічна хвороба серця (ІХС) і цереброваскулярні хвороби (ЦВХ) залишаться головними причинами смерті населення в усьому світі, а показник смертності збільшиться до 23,4 млн осіб.
Клінічно-параклінічні особливості перебігу атопічного дерматиту на тлі порушення мікробного пейзажу кишечника у немовлят
Authors: Koloskova O.K. , Marusyk U.I. , Kordunian N.V. 
Published: January 2022

Метою роботи було вивчення діагностичного значення загальноклінічних та параклінічних показників у дітей із проявами дисбактеріозу кишечника на тлі атопічного дерматиту для підвищення ефективності лікування даного захворювання. Проведене комплексне спостереження за 26 дітьми першого року життя, які мали клінічні прояви атопічного дерматиту. За даними бактеріологічного посіву випорожнень дітей розподіляли на дві клінічні групи порівняння. Першу групу становили 19 дітей зі значними порушеннями складу мікрофлори кишечника, що проявлялося дисбактеріозом ІІ–ІІІ ступеня тяжкості. Решта пацієнтів із відсутніми ознаками дисбактеріозу кишечника (за даними бактеріологічного дослідження випорожнень) увійшла до складу другої клінічної групи. Комплексне обстеження передбачало клінічну оцінку змін на шкірі за шкалою Eczema Area and Severity Index, відповідно до якої враховують площу ураження шкіри та інтенсивність морфологічних елементів висипання, а також загальний аналіз крові та визначення рівня загального імуноглобуліну E. У результаті проведених досліджень встановлено, що патологічне порушення мікробіоценозу кишечника у дітей, хворих на атопічний дерматит, підвищує ризик тяжкого перебігу цього захворювання у 2,8 раза, а ризик виявлення високої концентрації загального імуноглобуліну E у сироватці крові > 130,0 МО/мл — практично у 5 разів (відношення шансів — 4,8 (95% довірчий інтервал — 2,4–9,5)).
Recent Overview on Synthesis of 2-Mercaptobenzimidazole Derivatives and its Activities
Authors: Devi Poonam , Shahnaz Mohammad , Prasad D.N. 
Published: January 2022

A novel series 2-(1H-benzimidazol-2-ylsulfanyl) -N-(4-oxo-2-phenyl-thiazolidin-3yl) Various aldehydes and 2-acetamides have been used to synthesise -acetamide 5a–j (5-phenyl-[1,3,4]-oxadiazol-2-ylmethylsulfanyl) - 1H-benzimidazole 6a–j derived from a variety of benzoic acids. These compounds were tested in vitro for antibacterial activity against Gram positive bacteria Staphylococcus aureus and Enterococcus faecalis, Gram negative bacteria Klebsiella pneumoniae and Escherichia coli, and antifungal activity against Aspergillus fumigatus and Candida albicans. The in vitro cytotoxic properties of brine shrimp were investigated using a bioassay. Compounds 5b, 5d, 5g, 5i, 6b, 6e, 6f, and 6i demonstrated excellent activity against a panel of microorganisms, according to the results. 5b, 5g, 5i, 6b, 6f, 6h, and 6i were found to have good cytotoxic activities. Elements, IR, 1H-NMR, 13C-NMR, and MS were used to characterise all of the newly synthesised compounds.
Keywords: Antibacterial, Antifungal, 4-Thiazolidinone,1,3,4-Oxadiazole, Cytotoxicity.
Investigation of Proapoptotic Potential of Ipomoea carnea Leaf Extract on Breast Cancer Cell Line
Authors: Dubey Anubhav , Yadav Priyanka , Peeyush , , Verma Preeti , Kumar Roshan 
Published: January 2022

Cancer remains to be a major global healthcare burden as 18.1 million new cases and 96 million death occurred 2018 on the basis of report from the international agency for research on cancer Breast cancer is the most common cancer diagnosed in women causing the highest morbidity. Ipomoea carnea leaf extracts have been used as a chemotherapeutic agent due to their antioxidant, anti-inflammatory, anti-bacterial, and anti-tumor effect. The aim of the study is to evaluate the proapoptotic potential of Ipomoea carnea leaf extract on breast cancer cell lines (MCF-7). The proapoptotic potential of Ipomoea carnea leaf extract was assessed using an MTT assay. The cell morphological changes in Ipomoea carnea leaf extract-treated cells were observed under a phase-contrast microscope. The proapoptotic effect of Ipomoea carnea leaf extract was examined using DAPI staining. The MTT assay results showed a significant reduction in the viability of breast cancer cells after treatment with different concentrations of Ipomoea carnea leaf extract (5-80 µg/ml) for 24h. We observed the inhibitory concentration at 20 μg/ml. Morphological changes such as reduction in the number of cells, cell shrinkage, and cytoplasmic membrane blebbing indicate the hallmark features of apoptosis were observed in Ipomoea carnea leaf extract-treated cells. DAPI staining results showed that apoptotic nuclei are stained intensely, fragmented, and have condensation chromatin in treated cells. Therefore it can be concluded that Ipomoea carnea leaf extracts have a pro-apoptotic potential in the breast cell cancer lines (MCF-7).
Keywords: Ipomoea carnea, Breast cancer, MCF-7, Apoptosis
In-silico ADMET profile of Ellagic Acid from Syzygium cumini: A Natural Biaryl Polyphenol with Therapeutic Potential to Overcome Diabetic Associated Vascular Complications
Authors: Ramya S. , Murugan M. , Krishnaveni K. , Sabitha M. , Kandeepan C. , Jayakumararaj R. 
Published: January 2022

Plant Based Natural Products (PBNPs) are the primary source of natural antioxidants capable of neutralizing or eliminating harmful Reactive Oxygen Species (ROS). Oxidative stress contributes not only to the pathogenesis of type 2 diabetes (T2DM) but also to diabetic related vascular complications by lipid peroxidation. Oxidation induced DNA and protein damage leads to development of vascular complications like coronary heart disease, CVD, stroke, neuropathy, retinopathy, nephropathy, CKD, and other long term complications associated with diabetics. Likewise Multidrug resistance (MDR) is one of the major clinical challenges in cancer treatment and compromises the effectiveness of conventional anticancer chemotherapeutics. P-glycoprotein (P-gp) has been characterized as a major mechanism of MDR. Ellagic acid (EA) is a bioactive secondary metabolite widely distributed in vegetables and fruits (Strawberry, Grapes, Blackberry, Raspberry, Plums etc.) Chemically, EA is 2,3,7,8-tetrahydroxychromeno [5,4, -cde] chromene-5, 10-dione, a heterotetracyclic dimer of Gallic Acid (GA) molecules formed by oxidative aromatic coupling involving intramolecular lactonization. EA is associated with pharmacological activities such as anti-inflammatory, neuroprotective, cardio-protective, antioxidant, anti-mutagenic, multidrug resistance etc. EA has been marketed as a dietary supplement with claimed benefits against cancer, CVD, CKD and other metabolic disorders. However, pharmacological limitation of EA is attributed to its low solubility in water and reduced bioavailability. In the present study, bimolecular potential of EA has been bioprospected in the revised framework of ADMET pharmacoinformatics to further widen its biomedical applications.
Keywords: ADMET; Pharmacoinformatics; Ellagic Acid; Gallic Acid; Syzygium cumini; Alagarkovil Reserve Forest (ARF); Reactive Oxygen Species (ROS)
Antioxidant and Antidiabetic activity of hydroalcoholic flower extract of Woodfordia fruticosa (L.) Kurz
Authors: Giri Simran , Dey Ganesh , Dua Tarun Kumar 
Published: January 2022

Woodfordia fruticosa (L.) Kurz, (W. fruticosa) a member of the Lythraceae family, commonly known as dhaiphul, has been used in traditional medicine to cure common illnesses since ancient times. The most effective part of this plant is the flower which has a high demand in the national as well as the international market of the eastern south part of Asian countries. The present study focuses on exploring the presence of phytochemicals, antioxidants, and antidiabetic potential of hydroalcoholic extract of flower of W. fruticosa. Phytochemical test showed the presence of saponin, flavonoid, carbohydrates, alkaloids, tannin, anthraquinone, and triterpenoids in the extract, and it showed an effective result of total phenolic content, total flavonoid Content with the value of 371.96 ± 2.86 mg of gallic acid equivalent per gram of the extract and 113.82 ± 0.178 mg of quercetin equivalent per gram of dry weight. In vitro antioxidant assay, for the DPPH assay, the IC50 values were found 30.85 ± 0.36 μg/ml and 22.35 ± 0.54 μg/ml for the extract of W. fruticosa flower and ascorbic acid respectively and for the FRAP Assay, the reducing power assay of plant extract is lesser than standard (Ascorbic acid). W. fruticosa also showed significant hyperglycemic activity. In accordance with results, we can conclude that plant consists of a high polyphenolic and flavonoid group which help in antioxidant activity as well as the hydroalcoholic extract shows mild activity against diabetes.
Keywords: Woodfordia fruticosa, phytochemical, hydroalchoholic, antioxidants, antidiabetic, DPPH.
The Relationship between Antipsychotic Drug Use and Liver Enzyme Levels in People with Mental Disorders
Authors: Meiyanti Meiyanti , Mulia Lyfanni Fiesa , Pusparini Mulia, 
Published: January 2022

The long-term use of some drugs causes side effects in the form of elevated liver enzyme levels. Meanwhile, antipsychotic drug therapy in people with mental disorders induces liver injury which leads to an elevation in serum glutamic oxaloacetic and pyruvic transaminases. Therefore, this study aims to analyze the relationship between the uses of antipsychotic drugs with elevated liver enzymes in people with mental disorders. This observational study used a cross-sectional design that included 69 people with mental disorders. The respondents were selected based on consecutive non-random sampling, while the data were collected using a questionnaire to obtain the universal characteristics of the subjects, therapy duration, and antipsychotic type, as well as an examination of AST and ALT levels using the ultraviolet test method. Furthermore, data analysis was conducted using the chi-Square test with a significance level of p<0.05. The results showed that thirty-two among the respondents or 46.4% used atypical antipsychotics, while 37 or 73.0% received the drugs for 1-6 months. In the subjects receiving typical antipsychotics, 10 or 55.6% had a significant elevation in liver enzymes compared to others receiving atypical antipsychotics namely 6 (18.8%) or a combination of both drugs namely 6 (31.6%). Therefore, the type of antipsychotic used in therapy has a significant relationship with elevated liver enzymes in people with mental disorders (p=0.028).
Keywords: antipsychotics, drugs, elevated
Analysis of animal models based on pre-clinical symptoms of gout
Authors: Singh Yogendra , Mishra Pankaj , Kannojia Pushpendra 
Published: January 2022

Gout is a type of arthritis, which is a group of related disorders caused by episodes of abnormal inflammation in the joints. It is a metabolic disease characterized by high levels of uric acid in the blood. Uric acid is the end product of purine metabolism and hyperuricemia is caused by abnormalities of purine metabolism. Hyperuricemia is a risk factor for gout, heart disease, high blood pressure (hypertension), diabetes, and acute and chronic kidney disease. This research may attract widespread interest to researchers focusing on the different types of crystalline arthritis. There are over 100 types of arthritis. The most common forms are osteoarthritis (degenerative joint disease), rheumatoid arthritis, gout and pseudo-gout, septic arthritis, ankylosing spondylitis, juvenile idiopathic arthritis, still's disease etc.
Many animal models are available to get rid of gout, mainly the hyperuricemia animal model, monosodium urate air pouch gout model, Intra-articular gout in rat, Paw edema, Gouty Arthritis Model, and Gouty nephropathy model. Various investigations have created a reliable and economical animal model for arthritis in a relatively short brief timeframe, manifested by long-term gross and behavioral abnormalities along with intra-articular monosodium urate deposition and tophi formation.
Lately years, hyperuricemia disease has gradually increased in the world. There are many updates that can be made by taking the arthritis model. If such a situation prevails, then in a few years, the patients of gout can increase in great quantity and there is some treatment for this disease. In any case, further review is really needed to focus on its particular pathogenesis and drugs.
Keywords: Gout, Arthritis, Gout Animal Model, Inflammation, Hyperuricemia, monosodium urate, crystalline arthritis.