bluuebunny/crossref_metadata_2025_split huggingface dataset:
Superiority of Cubic Perovskites Oxides with Strong B‐O Hybridization for Oxygen‐Anion Intercalation Pseudocapacitance
Authors: Liang Tingting , Zhang Xiaqing , Su Lijun , Hou Ruilin , Yang Bingjun , Lang Junwei , Yang Shengrong , Yan Xingbin 
Published: May 2022

AbstractPerovskite materials can store charge through rapid oxygen anions intercalation. Although numerous perovskite materials owing to rich selections of A and B‐site elements are reported as electrodes of supercapatteries, the effect of the crystal structure of perovskite materials on their electrochemical performance has never been studied so far. Herein, using SrCo0.9Mo0.1O3−δ, SrFeO3−δ, Ba0.5Sr0.5Co0.8Fe0.2O3−δ, and LaMnO3−δ as research targets, it is proved that their corresponding cubic structure materials display the best electrochemical performance. And then, the origin of such superiority of cubic structure for SrCo0.9Mo0.1O3−δ is explored through experimental investigations and theoretical calculations. The results show that the increase in the content of oxygen vacancies and the enhancement of B‐O hybridization of cubic structure can optimize the electronic structure of the perovskite materials, thereby improving its conductivity and accelerating the reaction kinetics. The filtering strategy based on crystal structure proposed by this report will provide a new perspective to faster and more efficient choice of perovskite materials for supercapatteries.
Twisting Linear to Orbital Angular Momentum in an Ultrasonic Motor
Authors: Liu Jingjing , Li Zhengwei , Ding Yujiang , Chen An , Liang Bin , Yang Jing , Cheng Jian‐Chun , Christensen Johan 
Published: May 2022

AbstractAn ultrasonic motor built with a contactless meta engine block (MEB) is designed and experimentally demonstrated for twisting the linear momentum of sound emanating from a Helmholtz resonator‐based metasurface into orbital angular momentum (OAM). The MEB is capable of hosting highly efficient excitations of eigenmodes carrying desired OAM whose Bessel acoustic intensity patterns are enhanced by over ten times compared to the incident wave. Thanks to this efficiency, bidirectional ultrasonic OAM is capable of driving loads at speeds up to 1000 rpm at 4 W and remarkable sound radiation torque levels. Moreover, the possibility of using arbitrarily shaped MEBs is also demonstrated by engineering its physical boundary condition based on an analytically derived criterion to guarantee the high twisting efficiency of man‐made OAM. The results show how noninvasive driving of an ultrasonic motor can be made possible through appropriately designed momentum twisting, which opens the door to a new class of integrated mechanical devices solely powered by sound.
Stable Zinc Anodes Enabled by a Zincophilic Polyanionic Hydrogel Layer
Authors: Yang Jin‐Lin , Li Jia , Zhao Jian‐Wei , Liu Kang , Yang Peihua , Fan Hong Jin 
Published: May 2022

AbstractThe practical application of the Zn‐metal anode for aqueous batteries is greatly restricted by catastrophic dendrite growth, intricate hydrogen evolution, and parasitic surface passivation. Herein, a polyanionic hydrogel film is introduced as a protective layer on the Zn anode with the assistance of a silane coupling agent (denoted as Zn–SHn). The hydrogel framework with zincophilic –SO3− functional groups uniformizes the zinc ions flux and transport. Furthermore, such a hydrogel layer chemically bonded on the Zn surface possesses an anti‐catalysis effect, which effectively suppresses both the hydrogen evolution reaction and formation of Zn dendrites. As a result, stable and reversible Zn stripping/plating at various currents and capacities is achieved. A full cell by pairing the Zn–SHn anode with a NaV3O8·1.5 H2O cathode shows a capacity of around 176 mAh g−1 with a retention around 67% over 4000 cycles at 10 A g−1. This polyanionic hydrogel film protection strategy paves a new way for future Zn‐anode design and safe aqueous batteries construction.
Unusual Mesoporous Titanium Niobium Oxides Realizing Sodium‐Ion Batteries Operated at −40 °C
Authors: Liang Haichen , Liu Liangliang , Wang Nan , Zhang Wei , Hung Chin‐Te , Zhang Xingmiao , Zhang Zhenghao , Duan Linlin , Chao Dongliang , Wang Fei , Xia Yongyao , Li Wei , Zhao Dongyuan 
Published: May 2022

AbstractSodium‐ion batteries (SIBs) are a promising candidate for grid‐scale energy storage, however, the sluggish ion‐diffusion kinetics brought by the large radius of Na+ seriously limits the performance of SIBs, let alone at low temperatures. Herein, a confined acid–base pair self‐assembly strategy to synthesize unusual Ti0.88Nb0.88O4−x@C for high‐performance SIBs operating at room and low temperatures is proposed. The confinement self‐assembly of the acid–base pair around the micelles and confined crystallization by the carbon layer realize the formation of ordered and stoichiometric mesoporous frameworks with opened ion channels. Thus, the mesoporous Ti0.88Nb0.88O4−x@C exhibits rapid Na+ diffusion kinetics at 25 and −40 °C, which are one order higher than that of the nonporous one. A high reversible capacity of 233 mAh g−1, excellent rate (a specific capacity of 103 mAh g−1 at 50 C), and cycling performances (<0.03% fading per cycle) can be observed at 25 °C. More importantly, even at −40 °C, the mesoporous Ti0.88Nb0.88O4–x@C can still deliver the 161 mAh g−1 capacity, a high initial Coulombic efficiency of 60% and outstanding cycling stability (99 mAh g−1 at 0.5 C after 500 cycles). It is believed this strategy opens a new avenue for constructing novel mesoporous electrode materials for low‐temperature energy storage.
Pentafluorophenyl Group as Activating Group: Synthesis of α‐Deuterio Carboxylic Acid Derivatives via Et3N Catalyzed H/D Exchange
Authors: Peng Mengqi , Li Hengzhao , Qin Zixuan , Li Junyu , Sun Yanhao , Zhang Xiaoxu , Jiang Ling , Do Hainam , An Jie 
Published: May 2022

AbstractWe discovered that highly regioselective H/D exchange can be achieved on the α‐position of the pentafluorophenyl (Pfp) ester using Et3N as the catalyst and D2O as the deuterium source. Our computational and experimental results showed that the Pfp group can significantly increase the acidity of the α‐hydrogen of the ester. This mild reaction condition tolerated a variety of functional groups. 90%∼98% yields and 91%∼98% deuterium incorporations were obtained with all the tested Pfp esters. Taking advantage of the high reactivity of Pfp esters, a series of valuable α‐deuterio carboxylic acid derivatives, including herbicide, drugs and drug intermediates, have been synthesized using α‐deuterio Pfp esters as precursors.magnified image
Copper‐Catalyzed Chan‐Lam Coupling of NH‐Diaryl Sulfondiimines
Authors: Wang Yangyang , Meng Tingting , Su Shuaisong , Han Limin , Zhu Ning , Jia Tiezheng 
Published: May 2022

AbstractSulfondiimines, which contain a tetrasubstituted sulfur centre bearing two nitrogens and two carbon substituents, are a class of underexplored scaffolds in organic chemistry. Fascinated by some unique yet intriguing properties, sulfondiimines appear as leads in discovery industry, but the lack of efficient synthetic approaches holds back their further uptake by medicinal chemistry. Herein, a general and practical copper‐catalyzed Chan‐Lam coupling of NH‐diaryl sulfondiimines with arylboronic acids is presented. A simple copper catalyst efficiently facilitated the highly chemoselective construction of C−N bond, allowing the preparation of a variety of N‐arylated diaryl sulfondiimines in good yields under mild and environmentally benign conditions. An array of protecting groups on imine moieties were well tolerated, offering diversified accesses to NH,NAr‐diaryl sulfondiimines, a class of versatile building blocks. Moreover, an aza‐analogue of an EphB4 inhibitor featuring a sulfondiimine‐based pharmacophore was generated employing our Chan‐Lam coupling as the key step.magnified image
London Dispersion Favors Sterically Hindered Diarylthiourea Conformers in Solution
Authors: Rummel Lars , Domanski Marvin H. J. , Hausmann Heike , Becker Jonathan , Schreiner Peter R. 
Published: May 2022

AbstractWe present an experimental and computational study on the conformers of N,N′‐diphenylthiourea substituted with different dispersion energy donor (DED) groups. While the unfolded anti–anti conformer is the most relevant for thiourea catalysis, intramolecular noncovalent interactions counterintuitively favor the folded syn–syn conformer, as evident from a combination of low‐temperature nuclear magnetic resonance measurements and computations. In order to quantify the noncovalent interactions, we utilized local energy decomposition analysis and symmetry‐adapted perturbation theory at the DLPNO‐CCSD(T)/def2‐TZVPP and sSAPT0/6‐311G(d,p) levels of theory. Additionally, we applied a double‐mutant cycle to experimentally study the effects of bulky substituents on the equilibria. We determined London dispersion as the key interaction that shifts the equilibria towards the syn–syn conformers. This preference is likely a factor why such thiourea derivatives can be poor catalysts.
Chemical Synthesis and Antigenic Evaluation of Inner Core Oligosaccharides from Acinetobacter baumannii Lipopolysaccharide
Authors: Zhou Xian‐Yang , Li Ling‐Xin , Zhang Zhen , Duan Shi‐Chao , Huang Ying‐Wen , Luo Yi‐Yang , Mu Xiao‐Dong , Chen Zhi‐Wei , Qin Yong , Hu Jing , Yin Jian , Yang Jin‐Song 
Published: May 2022

AbstractAcinetobacter baumannii is currently posing a serious threat to global health. Lipopolysaccharide (LPS) is a potent virulence factor of pathogenic Gram‐negative bacteria. To explore the antigenic properties of A. baumannii LPS, four Kdo‐containing inner core glycans from A. baumannii strain ATCC 17904 were synthesized. A flexible and divergent method based on the use of the orthogonally substituted α‐Kdo‐(2→5)‐Kdo disaccharides was developed. Selective removal of different protecting groups in these key precursors and elongation of sugar chain via α‐stereocontrolled coupling with 5,7‐O‐di‐tert‐butylsilylene or 5‐O‐benzoyl protected Kdo thioglycosides and 2‐azido‐2‐deoxyglucosyl thioglycoside allowed efficient assembly of the target molecules. Glycan microarray analysis of sera from infected patients revealed that the 4,5‐branched Kdo trimer was a potential antigenic epitope, which is attractive for further immunological research to develop carbohydrate vaccines against A. baumannii.
Rational Electrolyte Design toward Cyclability Remedy for Room‐Temperature Sodium–Sulfur Batteries
Authors: Wu Junru , Tian Yao , Gao Yifu , Gao Ziyao , Meng Yuefeng , Wang Yao , Wang Xia , Zhou Dong , Kang Feiyu , Li Baohua , Wang Guoxiu 
Published: May 2022

AbstractRechargeable room‐temperature sodium–sulfur (RT Na–S) batteries are a promising energy storage technology, owing to the merits of high energy density and low cost. However, their electrochemical performance has been severely hindered by the poor compatibility between the existing electrolytes and the electrodes. Here, we demonstrate that an all‐fluorinated electrolyte, containing 2,2,2‐trifluoro‐N,N‐dimethylacetamide (FDMA) solvent, 1,1,2,2‐tetrafluoroethyl methyl ether (MTFE) anti‐solvent and fluoroethylene carbonate (FEC) additive, can greatly enhance the reversibility and cyclability of RT Na–S batteries. A NaF‐ and Na3N‐rich cathode electrolyte interphase derived from FDMA and FEC enables a “quasi‐solid‐phase” Na–S conversion, eliminating the shuttle of polysulfides. The MTFE not only reduces polysulfide dissolution, but also further stabilizes the Na anode via a tailored solvation structure. The as‐developed RT Na–S batteries deliver a high capacity, long lifespan, and enhanced safety.
The insistence on exclusion: The anti‐integrative impulse and thwarted mourning in large groups
Authors: Rao Jyoti M. 
Published: May 2022

AbstractThis paper explores resistance to equality‐promoting measures as the external manifestation of thwarted mourning of losses incurred in social trauma. This resistance, which is evidenced in backlashes against social justice, is termed the anti‐integrative impulse. Outlining the unconscious mechanisms that undergird both the desires for equality and desires to maintain inequality, the central importance of mourning in social equality movements will be established, using Moglen's model of mourning social injury and Butler's work on grievability. Common defenses against social justice efforts will be discussed and understood in terms of refusal to mourn collective losses.
Production of 8,11‐dihydroxy fatty acids from oleic and palmitoleic acids by Escherichia coli cells expressing variant 6,8‐linoleate diol synthases from Penicillium oxalicum
Authors: Shin Kyung‐Chul , Seo Min‐Ju , Kang Su‐Hwan , Oh Deok‐Kun 
Published: May 2022

AbstractRecombinant Escherichia coli cells expressing 8,11‐linoleate diol synthase (LDS) from Penicillium chrysogenum convert oleic and palmitoleic acids to 8‐hydroperoxy‐9(Z)‐octadecenoic acid (HPOME) and 8‐hydroperoxy‐9(Z)‐hexadecenoic acid (HPHME) only, respectively. However, recombinant E. coli cells expressing Q889A variant 6,8‐LDS from Penicillium oxalicum as an 8,11‐LDS converted oleic and palmitoleic acids to 8,11‐dihydroxy‐9(Z)‐octadecenoic acid (DiHOME) and 8,11‐dihydroxy‐9(Z)‐hexadecenoic acid (DiHHME), respectively, which were identified using liquid chromatography–tandem mass spectrometry analysis. To select suitable variants for producing these compounds, position 889 of 6,8‐LDS from P. oxalicum was substituted with other amino acids, and recombinant E. coli cells expressing Q889L and Q889A variants were chosen as the best biocatalysts for producing 8,11‐DiHOME and 8,11‐DiHHME, respectively. The optimal conditions for producing 8,11‐DiHOME or 8,11‐DiHHME using cells expressing Q889L or Q889A variant 6,8‐LDS were pH 6.5 and 30 °C with 5% (v/v) dimethyl sulfoxide, 60 g L−1 cells, and 10 g L−1 oleic acid or 7.5 g L−1 palmitoleic acid, respectively. Under these conditions, 10.7 g L−1 8,11‐DiHOME and 8.1 g L−1 8,11‐DiHHME were produced for 1.5 h with molar yields of 96.4% and 96.2% and productivities of 7.1 and 5.4 g L−1 h−1, respectively. The molar yields and concentrations of 8,11‐DiHOME and 8,11‐DiHHME were highest among those of other reported DiHOMEs and DiHHMEs. To the best of our knowledge, this is the first quantitative production of 8,11‐DiHOME and 8,11‐DiHHME.
Anlotinib plus platinum‐etoposide as a first‐line treatment for extensive‐stage small cell lung cancer: A single‐arm trial
Authors: Deng Pengbo , Hu Chengping , Chen Cen , Cao Liming , Gu Qihua , An Jian , Qin Ling , Li Min , He Baimei , Jiang Juan , Yang Huaping 
Published: May 2022

AbstractBackgroundAnlotinib as a third‐line or beyond therapy for extensive‐stage small‐cell lung cancer (ES‐SCLC) was studied. This single‐arm phase II trial was to investigate the value of anlotinib plus platinum‐etoposide as first‐line treatment in ES SCLC.MethodsThe primary endpoint was progression‐free survival (PFS) and objective response rate (ORR). The secondary endpoints included overall survival (OS), disease control rate (DCR), time to progression (TTP), duration of remission (DoR), and safety. The subgroups of preset liver metastasis and brain metastasis were analyzed.ResultsIn 35 ES‐SCLC patients, the median PFS, ORR, DCR, and OS were 8.02 months [95% confidence interval (CI): 6.90–9.66], 85.71% (95% CI: 69.74–95.19), 94.29% (95% CI: 80.84–99.30), and 15.87 months (95% CI: 10.38–18.89), respectively. The median PFS in the liver metastasis and brain metastasis subgroups was 7.33 months (95% CI: 4.76–9.69) and 7.34 months (95% CI: 5.68–9.20), respectively. The most common AEs with grade 3–4 were hand–foot syndrome (17%), granulocytosis (17%), stomatitis (14%), hypertriglyceridemia (11%), hypercholesterolemia (11%), as well as nausea and vomiting (11%), and no grade 5 AEs were recorded.ConclusionsAnlotinib combined with platinum‐etoposide provided an effective and safe therapy for patients with ES‐SCLC.
High recurrence of lymphedema and influencing factors in discharged breast cancer patients during the COVID‐19 pandemic: A multicenter, cross‐sectional survey
Authors: Peng Xin , Chen Renwang , Rao Zhenli , Yang Yi , Yan Yunli , Xia Ying , Wang Ting , Wang Jianying , Lu Fang , Pan Hong , Liu Yan , Cheng Jing , He Qin 
Published: May 2022

AbstractBackgroundThere has been a delay in the detection and treatment of lymphedema in breast cancer patients during the lockdown owing to quarantine and limited social activity. Moreover, this scenario has caused psychosocial issues in these patients. Given that there is scarce information on the prevalence and influence of lymphedema during the coronavirus disease (COVID‐19) pandemic, we aimed to estimate the prevalence of lymphedema recurrence and its influencing factors among discharged breast cancer patients during the COVID‐19 pandemic.MethodsThis was a multicenter, cross‐sectional, hospital‐based survey of discharged breast cancer patients was conducted during the COVID‐19 pandemic in eight first‐class hospitals in Wuhan, China. The Norman Questionnaire was used to assess lymphedema. Univariable and multivariable binary logistic regression analyses were performed to identify factors influencing moderate or severe lymphedema. Differences in living characteristics, anxiety, and depression were compared between the no/mild lymphedema group and the moderate/severe lymphedema groups. Preferences for lymphedema management during the pandemic were determined.ResultsOverall, 202 patients were included in this study, and 191 of them reported recurrent lymphedema (prevalence: 94.6%, 95% confidence interval [CI] 90.5% to 97.3%). Among them, 134 and 57 had mild and moderate/severe lymphedema, respectively. In 191 patients, the main symptoms were swelling (140; 69.3%) and pain (56, 27.7%). Multivariable regression showed that older age (odds ratio [OR], 1.06; 95% CI: 1.02–1.10), radical surgery (OR = 4.35, 95% CI: 1.54–12.50), and fully complete radiotherapy (OR = 2.62, 95% CI: 1.17–5.87, p = 0.019) were associated with an elevated risk of moderate/severe lymphedema. The moderate/severe lymphedema group experienced a higher rate of anxiety and depression than the no/mild lymphedema group did. Patients equally preferred treatment in the hospital and self‐care at home.ConclusionDuring the COVID‐19 pandemic, high prevalence of lymphedema was observed in patients Age, radical surgery and fully completed radiotherapy were associated with increased risk of severer lymphedema. Meanwhile, the patients with severe lymphedema experienced psychological distress. While the Covid‐19 pandemic was still raging, continuous efforts should be made to identify patient at risk of lymphedema and distribute feasible guidance and education for self‐management in lymphedema.
Clinical presentation, outcome, and prognostic markers in patients with intravascular large B‐cell lymphoma, a lymphoma study association (LYSA) retrospective study
Authors: Bonnet Antoine , Bossard Céline , Gabellier Ludovic , Rohmer Julien , Laghmari Othman , Parrens Marie , Sarkozy Clémentine , Dulery Rémy , Roland Virginie , Llamas‐Gutierrez Francisco , Oberic Lucie , Fornecker Luc‐Matthieu , Bounaix Laura , Villemagne Bruno , Szablewski Vanessa , Choquet Sylvain , Bouabdallah Krimo , Traverse‐Glehen Alexandra , Mohty Mohamad , Sanhes Laurence , Houot Roch , Gastinne Thomas , Leux Christophe , Le Gouill Steven 
Published: May 2022

AbstractBackgroundIntravascular large B‐cell lymphoma (lVLBCL) is a very rare type of large B‐cell lymphoma.MethodsWe conducted a retrospective study on IVLBCL patients treated from 2000 to 2016 in LYSA cooperative group centers.ResultsSixty‐five patients were identified in 23 centers. Median age at diagnosis was 69 years (range 23–92). Thirty‐four patients (64%) had an IPI score >3 and 40 patients (67%) had a performance status ≥2. The most frequent extra‐nodal locations were bone marrow (n = 34; 52%), central nervous system (n = 25; 39%), and skin (n = 21; 33%). Nodal involvement and endocrine system were observed in 34% (n = 22) and 18% (n = 12) of all cases, respectively. Twenty‐six patients (41%) had macrophage activation syndrome. Tumor cells were frequently CD5 positive (52%) with a non‐germinal center origin (86%). BCL2 was expressed in 87% of all samples analyzed (n = 20) and 43% of patients had a MYC/BCL2 double expression. Fifty‐six patients were treated with a regimen of chemotherapy containing rituximab, among whom 73% reached complete remission. The median progression‐free survival (PFS) and median overall survival (OS) were 29.4 months and 63.8 months, respectively. History of autoimmune disorder (Hazard ratio [HR] 3.3 [1.4–7.8]; p < 0.01), nodal involvement (HR 2.6 [1.4–5.1]; p < 0.01), lack of anthracycline (HR 0.1 [0–0.4] for use; p < 0.001), or no intensification at first‐line regimen (p = 0.02) were associated with worse PFS. High‐dose methotrexate use was not associated with better PFS or OS.ConclusionsOur study highlights the aggressive clinical picture of IVLBCL, in particular the frequency of macrophage activation syndrome, and the need for new therapies despite a response to R‐CHOP‐like regimen similar to non‐intravascular diffuse large B‐cell lymphomas.
Lanthanum hydroxide inhibits vascular calcification by regulating the HIF‐1 pathway
Authors: Wang Shengnan , Zhao Lulu , Liu Hong , Han Ruilan , Liu Yang , Gao Jie , Bu Ren , Li Bing , Sun Lijun , Hao Jian , Zhao Jianrong , Li Gang 
Published: May 2022

AbstractThe main reason for the high incidence of cardiovascular disease in chronic kidney disease (CKD) patients with vascular calcification (VC) is also the main cause of death in CKD patients. Lanthanum hydroxide (LH) has an inhibitory effect on VC in chronic renal failure; however, the mechanism of its inhibition is poorly defined. Here, we used network pharmacology analysis and found that hypoxia‐inducible factor (HIF) is related to VC. In a CKD rat model induced by adenine combined with high phosphorus (1.2%), LH improved the survival rate and inhibited the occurrence and development of VC. In an in vitro study, we found that lanthanum chloride inhibited the occurrence of VC induced by high phosphorus and reduced the production of reactive oxygen species. This study thus revealed that LH can inhibit the occurrence and development of VC by inhibiting the activation of HIF‐1.
Evaluation of newly established buffalograss for tolerance to glyphosate
Authors: Bertucci Matthew B. , Karcher Doug E. , Richardson Mike D. , O'Brien Daniel P. 
Published: May 2022

AbstractBuffalograss [Buchloe dactlyoides (Nutt.) Engelm.] is gaining popularity as a turfgrass for low maintenance sites, where irrigation and regular mowing or fertility may not be available. Unfortunately, weed species also thrive in low maintenance sites. This field study was conducted to assess the utility of glyphosate as a selective herbicide in newly established buffalograss. Buffalograss (cultivar Cody) burs were sown into newly renovated sites in Fayetteville, AR, in the summer of 2017 and 2018. Glyphosate was applied at 1, 3, and 8 weeks after emergence (WAE) of buffalograss seedlings at rates of 0.15, 0.325, 0.75, 1.5, 3.0 lb a.e. acre–1 of glyphosate and one untreated control. These rates correspond to 0.1 time (×), 0.25×, 0.5×, 1.0×, and 2.0× of the highest labeled rate of 1.5 lb a.e. acre–1 of glyphosate (64 fl oz acre–1, RoundUp Pro, Bayer Cropscience). Following application, plots were assessed using visual ratings of turf quality on a 1–9 scale at weekly intervals for 10 weeks. One week after applications at 8 WAE, images were taken of each plot and analyzed for dark green color index (DGCI) as a quantified measure for the green value of living foliage in treated areas. In both years and all application timings, buffalograss turf quality was reduced to an unacceptable quality when treated with glyphosate at 0.25× of the maximum labeled rate and above. At the 0.1× rate of glyphosate, buffalograss turf quality was not significantly reduced in either year at any application timing.