bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circadian Rhythm and Risk of Hemorrhagic Transformation after Acute
Ischemic Stroke Treated with Intravenous Thrombolysis - A Systematic
Review
Authors: Stan Adina , Dragos Hanna , Strilciuc Stefan , Ilut Silvina , Vacaras Vitalie , Cozma Angela , Panaitescu Paul Stefan , Stan Horatiu , Muresanu Dafin F. 
Published: October 2022

Background:
A circadian pattern for the onset of acute ischemic stroke (AIS) has been described,
with a higher risk in the early morning and a lower risk during nighttime. However, data assessing
the circadian distribution of hemorrhagic transformation after intravenous thrombolysis (ivT)
are still incongruent.

Objectives:
This review aimed to evaluate whether the time interval based on AIS onset or ivT time
could influence the occurrence of intracranial hemorrhage (ICH) related to ivT and if the circadian
rhythm of endogenous production of tissue plasminogen activator (t-PA) favors ICH occurrence.

Methods:
We conducted a systematic review following the PRISMA guidelines, searching PubMed and
Embase for articles in English using the keywords: 'stroke', 'thrombolysis', and 'circadian'. Articles investigating
the AIS onset or ivT time effects on circadian variations of ICH in AIS adult patients treated with
ivT were included. Based on ICH's incidence and odds ratio, time intervals associated with higher risk
and time intervals associated with lower risk were defined. The Newcastle-Ottawa Scale was used to assess
the risk of bias. The resulting data were reported in a qualitative narrative synthesis.

Results:
From the 70 abstracts returned by electronic literature search, six studies with 33,365 patients
fulfilled the inclusion criteria, out of which three were retrospective analysis studies, one case-control
study, one prospective study, and one post hoc analysis of a multicentre trial. Some studies assessed
the relationship between ICH occurrence and circadian rhythm depending on AIS onset time (n = 2),
treatment time (n = 2), or both (n = 4). All studies investigated the patients' comorbidities as confounding
variables for the circadian pattern of symptomatic ICH (sICH). Two studies found no association
between AIS onset or ivT time and patient risk factors, but the other four found several differences and
used multivariate logistic regression models to balance these covariates. The overall score of the Newcastle-
Ottawa scale was 83.3%, which might be interpreted as overall high quality.

Conclusions:
ICH occurred after ivT seems to follow a circadian pattern; the 18:00-00:00 time frame was
the safest one, and patients with AIS onset or ivT time between these hours had the lowest incidence of
any ICH, including sICH. The 06:00-12:00 block was associated with the highest incidence of ICH and
sICH. However, the analysis is limited by the small number of included studies and the heterogeneous
findings reported. Further homogenized studies using comparable time frames and sICH definitions are
needed to demonstrate this circadian pattern. The review protocol was registered in the OSF database under
reference UHNF, doi:10.17605/OSF.IO/UHNF6.
Tirzepatide: A New Generation Therapeutic for Diabetes Type 2
Authors: Al-Horani Rami A. , Chedid Milad 
Published: October 2022

Abstract:
Tirzepatide (mounjaro®) is a derivative of the human glucose-dependent insulinotropic
polypeptide (GIP) hormone with a position-20 being modified with 1,20-
eicosanedioic acid via a chemical linker. It acts as a glucagon-like peptide-1 (GLP-1)
receptor and GIP receptor agonist. It has recently been approved by FDA as an adjunct
therapy to exercise and diet to improve glycemic control in patients with type II diabetes
mellitus (T2DM). It represents a new transforming paradigm in the management of
T2DM. This mini-review will shed light on its different pharmacokinetic and pharmacodynamic
aspects.
Assessment of the level of fibrosising factors in patients with coronary heart disease and chronic kidney disease
Authors: Samakaev A. S. , Glova S. E. , Khaisheva L. A. , Shlyk S. V. 
Published: October 2022

Objective: to study the level of fibrosing factor in patients with coronary heart disease and chronic kidney disease.Materials and methods: the study included 115 patients, mean age was 67.56 ± 12.42 years (63 men and 52 women) with ischemic heart disease (CAD), stable angina (tension), functional class 1–3, chronic kidney disease (CKD) C1-C4. The level of serum fibroblast growth factor 23 (FGF 23) was assessed using a multimatrix enzyme immunoassay for the quantitative determination of FGF 23 (Biomedica FGF 23).Results: in patients with CAD and CKD, the level of serum FGF23 progressively increases as the stage of CKD worsens and can be regarded as an early marker of CKD progression in patients with CAD. When studying the correlation between the level of serum FGF 23 and clinical and laboratory data, it was found that there is a correlation between FGF 23 and age, creatinine, urea, glomerular filtration rate.Conclusion: in patients with CAD and CKD, it is advisable to use the determination of the level of fibrosis factors to identify patients with a high risk of cardiovascular complications.
Development of healthcare and social care services for the elderly population
Authors: Kasimovskaya Nataliya , Egorova Elena , Shustikova Natalia , Poleshchuk Ilia , Khvostunov Konstantin , Malkina Olga , Ermilova Victoria 
Published: October 2022

Background & aim:
The percentage of older people has been growing in all economically developed countries over the past several decades. The purpose of this research was to optimize the healthcare and social care model based on the in-depth study of social, hygienic and clinical characteristics of elderly individuals.
Materials & methods:
The authors' study included individuals aged 65 years and older.
Results:
The proportion of elderly and senile individuals increased from 15.3% in 2011 to 18.6% in 2020. The authors found that the existing healthcare system does not meet the needs of the aging population and thus developed a new organizational model for healthcare and social care services designed to integrate the activities of social welfare centers and local polyclinics.
Conclusion:
Implementation of the authors' model enables a range of healthcare and social care services and allows for management of a patient's health based on individual characteristics.
Field Based High Throughput Phenotyping Enables the Discovery of Loci Linked to Senescence and Grain Filling Period
Authors: Adak Alper , Desalvio Aaron J , Murray Seth C 
Published: October 2022

Field Based High Throughput Phenotyping Enables the Discovery of Loci
Linked to Senescence and Grain Filling Period
ORCiD: [Alper Adak; 0000-0002-2737-8041]
Keywords: Grain filling period, field-based high throughput phenotyping,
days to senescence, temporal phenotype.
Senescence occurs progressively over time and is variable among
different genotypes. To examine the temporal and genetic variation of
senescence, 280 maize hybrids and 520 maize recombinant inbred lines
(RILs) grown in 2017 and 2018 were investigated. Hybrids were grown in
late and optimal planting trials; RILs were grown in irrigated and
non-irrigated trials, both based on range-row design with two
replications. Two types of Unmanned aerial systems (UAS, also known as
UAV or drones) were flown over the germplasm between 14 and 20 times
respectively. Temporal senescence of each row-plot in hybrids and RILs
was scored visually according to percentile scoring using four to five
rectified drone images between ~90 and
~130 days after planting. A mechanistic growth model was
fit to each genotype using the temporal senescence scores, resulting in
0.94 and 0.97 R 2 for hybrids and RILs. Days to senescence (DTSE) and
grain filling period (GFP) were calculated for each row plot using the
developed mechanistic growth model. To predict the genotypic value for
each RIL and hybrid, a mixed model with three-way interaction model
(Genotype*Flight*Environment) was then run. Correlation was calculated
~0.84 and ~0.88 between grain yield and
GFP and DTSE in hybrids. A major quantitative trait locus was also
discovered on chromosome 1 (295.5 to 296.8 kb; 15% explained) linked to
GFP in RILs. GFP is known to be physiologically important, UAS provided
an easily scalable measure which can greatly increase the evaluation of
variation in the field.
META-ANALYSIS OF THE INFLUENCE OF GROUP INVESTIGATION TYPE COOPERATIVE MODELS ON STUDENT’S COMPETENCE IN PHYSICS LEARNING
Authors: Tanjung Rizki Anisa , Festiyed Festiyed , Mayasari Tantri 
Published: October 2022

Various studies related to the influence of group investigation type cooperative models on student competence have been widely conducted. Researchers are interested in conducting meta-analysis research to summarize various studies on the influence of this type of group investigation cooperative model. After the study, researchers concluded that this cooperative model of group investigation type is very effectively applied at the junior high level and effective at the high school level. The influence of cooperative models of group investigationtypes p there are physics subject matter also has a high positive influence for 8 subject matter, namely circular motion, momentum and impulse, static electricity, dynamic fluid, static fluid, kinetic theory of gases, light and optics, vibrations and waves, and dynamic and ineffective electricity on subject matter magnitude and measurement, straight motion, Newton's laws, effort and energy, temperature and heat, rotational dynamics and rigid equilibrium of objects, and elasticity. This group investigation type cooperative model is also able to improve students' competence on changes in concepts, attitude skills, procedural abilities, and generic skills compared to students' cognitive learning outcomes and conceptual knowledge.
Optimization research on prefabricated concrete frame buildings based on the dynamic equation of eccentric structure and horizontal-torsional coupling
Authors: Li Xiang , Sun Xiaomeng , Mohamed Hamdy 
Published: October 2022

Abstract
In order to study the optimization of the prefabricated concrete frame building based on the dynamic equation of the eccentric structure's horizontal-torsional coupling. First, the author analyzes the characteristics of several current representative structural forms and the problems existing in the process of industrialization. Through research on prefabricated houses at home and abroad, the key technologies involved in key processes such as design, component production, and prefabricated component installation are discussed in detail, and the problems existing in the existing technology are analyzed. Then, for a single-layer eccentric structure with soil-structure interaction, the dynamic equation is established to solve the parameters that affect the dynamic characteristics of the eccentric structural system. Finally, combined with the actual engineering, the application status of the key technologies in the construction process is analyzed, and the relevant research results are used in the project to verify the validity of the research results. The experimental results show that: Through engineering practice, we have a clearer understanding of the design and construction of prefabricated buildings, and have a deeper understanding of related technologies, and also verified the feasibility of related technologies in engineering.
Information transmission simulation of Internet of things communication nodes under collision free probability equation
Authors: Xu Siping , Chen Lan , Alshalabi Riyad 
Published: October 2022

Abstract
Based on the background of the Internet of Things, this paper proposes a communication node information transmission protocol for wireless network sensors. This method adopts the strategy of alternating listening and sleeping. It can also reflect the overall characteristics of the monitoring range while meeting the real-time requirements. The protocol method proposed in this paper has the characteristics of low energy consumption and no synchronization. The algorithm reserves multi-hop timeslots at one time in the data forwarding direction at the frontier of data transmission. It avoids the delay caused by intermittent transmission of single-packet data on the forwarding path. The simulation results show that the energy efficiency and delay performance are much better than SMAC.
Learning Style Analysis for Differentiated New Paradigm Learning in Public Senior High School 1 Semendawai Suku III East Oku
Authors: Dariyani Nuriz , Marlina* Leni , Sriyanti Ida , Sudirman Sudirman , Meilinda Meilinda 
Published: October 2022

Learning with a new paradigm is designed based on the principle of differentiated learning so that each student learns according to their needs and stage of development. This study aims to obtain an overview of the trends in the learning styles of students at public senior high school 1 Semendawai Suku III East Oku. These results are intended for initial assessment in preparing differentiated teaching modules that will be used in differentiated learning. This research is a qualitative descriptive study. The method used is a survey using a learning style questionnaire developed by chislett and chapman. The survey results were then analyzed and grouped by researchers according to the characteristics of students' learning styles, namely visual, auditory, and kinesthetic learning styles. The sample used is class x as much as one class, this class is a model to find out how learning styles can be found in other classes. Based on the results of the study, it was found that every student has a tendency to learn styles, be it visual, audio, or kinesthetic. From the analysis of the learning styles of students at public senior high school 1 semendawai Suku, east oku, the results showed that the tendency of students' learning styles was audio by 46%, visual learning styles by 39%, and kinesthetic learning styles by 15%. These results indicate that in one class the tendency of students' learning styles varies. Differentiated learning needs to be developed by educators in order to facilitate the needs of students' diverse learning styles. These results indicate that in one class the tendency of students' learning styles varies. Differentiated learning needs to be developed by educators in order to facilitate the needs of students' diverse learning styles
Изображение птиц на поливной керамике производства Юго-Восточного Крыма из раскопок Азака
Authors: Мойсова Елизавета Дионисовна 
Published: October 2022

В статье рассматривается найденная на территории города Азова крымская поливная керамика XIV в. с орнитоморфным декором, выполненным в технике «сграффито», «сграффито с полихромной расцветкой» или сочетанием техник «сграффито» и «резерв». На основании наиболее сохранных экземпляров были выделены следующие композиции, главным или одним из ключевых персонажей которых является птица: длинноногая птица в высокой траве со сложенными на спинке крыльями, украшенными стилизованным растительным орнаментом; крупная коротконогая птица в зарослях с большим расширяющимся хвостом и оперением, переданным в виде рядов фестончатых линий; птица с расправленными над спиной крыльями на фоне спиралеобразных, волнообразных линий; шествие птиц по кругу, изображённых схематично; небольшая птица с расправленными над спиной крыльями, широко раскрывающая клюв, стоящая перед большой удлинённый предмет; кормящаяся птица, вписанная в шестиугольную фигуру, образованную двойными линиями, между которыми находится орнамент; маленькая птичка в круглом, украшенном растительностью, медальоне; птица и рыба, соприкасающиеся клювом и ртом соответственно. Также были детально рассмотрены варианты изображения разных частей птицы, их орнаментация, на чём мастер акцентировал свое внимание: прорисованные зрачки, носовая кость, хохолок, дополнительная орнаментация на шее, выпуклая грудка, сложенные или расправленные орнаментированные крылья и другие особенности.
Беседка Селямет Герая в Бахчисарайском Дворцовом комплексе
Authors: Ломакин Дмитрий Анатольевич , Айбабина Елена Акимовна 
Published: October 2022

На планах Бахчисарайского ханского дворца XVIII–XX вв. (Дж. Тромбара, В. Гесте, Н. П. Краснова, А. Л. Ротача) отмечен «Старый дворец» крымских ханов, построенный, вероятно, в XVI в. при хане Сахибе I Герае (правил в 1532–1551 гг.), позднее – лишь сохранившаяся галерея. На протяжении периода своего существования дворец оберегался ханами и неизменно восстанавливался после разрушений, будучи одним из первых сооружений на территории дворцового комплекса, служил символом ханской власти, связанным с зарождением новой столицы – Бахчисарая. В 20-е гг. XIX в. «Старый дворец» был разобран, как полностью обветшавший, однако реставраторы сохранили его галерею, позднее названную «беседкой Селямет Герая». Беседка с фонтаном в центре помещения, стоявшая на высоком цоколе, с мраморной колоннадой и арочными проемами стрельчатой формы, была украшена лепным декором и росписью в натуралистической и барочной стилистике, вошедшей в искусство и ремесло Турции и Крымского ханства во второй половине XVI – XVIII вв. Памятник утрачен в середине XX в.
Gambaran Independent dan Interdependent Self-Construal pada Mahasiswa Indonesia
Authors: Sulastra Marissa Chitra , Handayani Vida 
Published: October 2022

Penelitian ini bertujuan untuk mendapatkan gambaran self-construal pada mahasiswa di Indonesia. Indonesia memiliki kebudayaan kolektivistik dengan ciri utama konformitas terhadap kelompok sebagai hal penting bagi masyarakatnya. Ketika budaya kolektivistik diinternalisasi menjadi cara pandang mengenai diri sendiri, maka akan membentuk interdependent self-construal. Penelitian ini menggunakan sampel sebanyak 521 mahasiswa Indonesia yang terdaftar sebagai mahasiswa aktif di universitasnya, merupakan kewarganegaraan Indonesia, tinggal di Indonesia dan bersedia mengisi kuesioner hingga selesai. Responden diambil menggunakan teknik purposive sampling. Instrumen yang digunakan dalam penelitian ini merupakan hasil terjemahan dari kuesioner Self-Construal milik Singelis (1994). Hasil penelitian menggunakan uji beda Wilcoxon menunjukkan bahwa mahasiswa Indonesia memiliki independent self-construal dan interdependent self-construal yang seimbang (Z = -0,712, sig = 0,477). Dapat disimpulkan bahwa mahasiswa Indonesia menghayati dirinya sebagai bagian terpisah dari orang lain sekaligus terintegrasi dengan orang lain. Manfaat penelitian digunakan sebagai dasar penelitian lanjutan dengan topik serupa dan menjadi sumber informasi bahwa mahasiswa Indonesia menginternalisasi budaya kolektivistik dan individualistik sebagai cara pandang mengenai dirinya.
Kata kunci: Self-Construal, Psikologi Lintas Budaya, Indonesia, Budaya Sunda
Effikasi Diri dan Performansi Akademik: Studi Meta Analisis
Authors: Fun Lie Fun 
Published: October 2022

This meta-analysis study aims to see how the true correlation between self-efficacy and academic performance. Publications in the literature are gathered by investigating articles related to the theme. Based on the criteria set by researcher from 15 journals which are the results of research from the period 2006 to 2020, 16 studies were found in the analysis. Journal searches are obtained through an online data base. Data analysis was performed using 2 meta-analysis techniques for artifact data, namely correction of sampling errors and correction of measurement errors. The meta-analysis was carried out with a total sample size of N = 5039. The results of the meta-analysis show that self-efficacy has a positive correlation with academic performance of 0,399.
Keywords: meta-analysis, self-efficacy, academic performance
Hubungan antara Dukungan Orang Tua dengan Adaptabilitas Karier pada Siswa SMA di Jakarta
Authors: Angela Glory , Gunawan William 
Published: October 2022

Tujuan dari penelitian ini adalah untuk mengetahui adanya hubungan antara dukungan orang tua dengan adaptabilitas karier pada siswa SMA di wilayah DKI Jakarta. Penelitian ini memiliki hipotesis bahwa terdapat hubungan yang positif dan signifikan antara dukungan orang tua dengan adaptabilitas karier pada siswa SMA di wilayah DKI Jakarta. Sebanyak 195 siswa SMA yang berusia 15-18 tahun berpartisipasi dalam penelitian ini dengan teknik purposive sampling. Penelitian ini menggunakan pendekatan kuantitatif dengan menggunakan skala dukungan orang tua dan Career Adapt-Ability Scale (CAAS). Data yang telah didapatkan, dianalisis menggunakan tehnik Spearman Correlation. Hasil penelitian menunjukkan nilai r = 0,257(p = 0,001<0,05) artinya hasil penelitian sesuai dengan hipotesis, yaitu terdapat hubungan yang positif antara dukungan orang tua dengan adaptabilitas karier pada siswa SMA di Jakarta. Beberapa saran melalui penelitian ini yaitu meneliti variabel lain yang berkontribusi lebih, melihat kontribusi antar variabel dan memodifikasi alat ukur sesuai dengan keadaan siswa.
Kata kunci: adaptabilitas karier; dukungan orang tua; remaja
Hubungan antara Dimensi Calling dan Career Adaptability pada Guru SMA
Authors: Christine Christine , Riasnugrahani Missiliana 
Published: October 2022

Penelitian ini bertujuan untuk mengetahui hubungan antara dimensi calling dan career adaptability pada guru SMA yayasan “X” Bandung. Melalui teknik purposive sampling diperoleh 66 guru yang memiliki masa kerja minimal satu tahun. Rentang usia guru berkisar antara 24-67 tahun, dan lebih dari setengahnya adalah laki-laki. Alat ukur yang digunakan adalah Calling and Vocation Questionnaire (CVQ) dan Career Adapt-Abilities Scale Short–Form (CAAS-SF), yang memiliki nilai reliabilitas yang baik. Pengolahan data dengan pearson correlational analysis ditemukan bahwa dimensi presence of calling dan career adaptability berkorelasi positif secara signifikan. Hal ini berarti guru yang memiliki keyakinan bahwa pekerjaannya adalah suatu panggilan, akan lebih mudah untuk beradaptasi dengan perubahan maupun tantangan yang terjadi dalam karirnya. Oleh karena itu, sekolah diharapkan dapat membantu guru untuk mempertahankan dan meningkatkan calling sehingga dapat membantu guru beradaptasi dalam pekerjaan dengan baik.
Kata kunci: Presence of Calling, Search for Calling, Career Adaptability, Guru
Marco geológico regional y litológico de la zona arqueológica de Huapalcalco, Tulancingo, Hidalgo
Authors: Ortiz-Hernández L. E. , Escamilla-Casas J. C. , Cruz-Chávez E. , Castro Mora J. 
Published: October 2022

La zona arqueológica de Huapalcalco se localiza a 4 km al norte de la ciudad de Tulancingo, Hidalgo, sobre la ladera oeste del domo Napateco. Los monumentos arqueológicos están emplazados al pie de una unidad ignimbrítica riolítica con disyunción columnar, producida durante el enfriamiento de ésta, la cual forma parte del complejo de domos riolíticos del Yolo y de las últimas emisiones piroclásticas relacionadas a la caldera de Tulancingo (Plioceno, 32 km de diámetro) o la de Acoculco (Pleistoceno, 18 km de diámetro), la cual está anidada a la primera. El complejo dómico El Yolo es de edad Plioceno y-tiene una longitud aproximada de 30 km y una orientación general N65°O en su eje mayor y 15 km en su eje menor, en la porción oriental de la ciudad de Tulancingo, en el sector oriental de la Faja Volcánica Transmexicana. Es de composición silícica con litología variada: derrames de lava riolítica a dacítica, flujos piroclásticos formando brechas de derrame con intercalaciones de lentes de obsidiana, vitrófidos e ignimbritas. Este complejo es intrusionado por diques basálticos, posiblemente cuaternarios. Los vestigios arqueológicos líticos poseen características del lugar o sus inmediaciones, ya que corresponden a rocas ígneas extrusivas como basalto y escoria basáltica, toba riolítica a dacítica, escasa riolita y andesita y sólo hay discrepancia en una muestra de roca intrusiva (monzogabro), la cual no existe en la zona de influencia regional.