bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Narrative Review of the Use of Augmented and Virtual Reality as an Alternate to Traditional Mirror Therapy in Dealing with Post Amputation Phantom Limb Pain (PLP)
Authors: Bhatnagar Aayushi , Chandi Dhruba 
Published: February 2022

This article reviews the existing data on the use of augmented and virtual reality in the treatment of post amputation phantom limb pain (PLP) in order to curb the shortcomings of the treatment modality already in place: traditional mirror therapy. PLP is a highly prevalent condition- as high as used in 65%-70% amputees, which has many therapies in place varying from medicinal options such as anaesthetics, drugs that help cure depression and injections of botulism toxin, inter-positional treatments such as stimulation of spinal cord, correctional surgery and more. Visio- dynamic approaches such as reflective surface therapy (mirror) and augmented reality treatments which attempt at normalizing the representation of the amputated limb from the cortex and improving the correlation between the authentic and anticipated sensory feedback. Previous studies have consistently demonstrated the efficacy of traditional therapy using mirrors in post upper limb amputation PLP where a setup with a mirror is used to trick the mind of the patient in making the patient see a reflection of the good limb and exercising it to give the effect of exercise of the amputated limb, however because of its crude setup, it proves to have a few limitations which can be overcome using virtual reality. Virtual reality is integrating in our lives today as video games and simulations. It has a lot of application in diagnosing, prophylaxis and treatment. Virtual reality is a boon to the medical field in the sense that it allows one to visualize and practice endlessly without needing any additional resources. Incorporating VR into the treatment, patient centered holistic care can be achievable and patient's quality of life and satisfaction can be improved.
Comparative Evaluation and Co-relation of Difficult Airway and Temporomandibular Joint Disorder in Skeletal Class II Vertical Growth Pattern and Class-I Malocclusion – An Observational Study
Authors: Rathi Shruti , Gilani Rizwan 
Published: February 2022

Introduction: In the recent years it is observed that there has been increase in the no. of cases of Temporomandibular joint disorder and TMJ pain related problem, many of patients go undiagnosed and may transform into irreversible severe cases if the predisposing factors are present. There are different clinical and radiographical methods of diagnosing TMD cases, and one of the simplest ways to diagnose and categorize a Temporomandibular disorder is Helkimo index. The present study is encouraged to measure difficult airway, in Class II malocclusion with TMD.
Materials and Method: The observational study will be conducted in Orthodontics and Dentofacial Orthopaedics department, Sharad Pawar Dental College, Sawangi (M), Wardha in collaboration with department of Radiology, Acharya Vinoba Bhave Hospital. Sawangi (M), Wardha. Total 30 patient in age group of 20 to 50 years, will be selected from the patients coming to Out Patient Department (OPD) of Orthodontics and Dentofacial Orthopaedics, Wardha. MRI of patients with skeletal class II vertical growth pattern and class I malocclusion having temporomandibular joint disorder will be taken and then airway is to be evaluated.
Expected Results: It is expected that individuals with skeletal class II vertical growth pattern and class I malocclusion with temporomandibular joint disorder may have a compromised airway.
Conclusion: No such study has been carried out to evaluate co-relation of difficult airway and temporomandibular joint disorder. Thus, this study aims to evaluate it in skeletal class II vertical growth pattern and class I malocclusion.
Predictive Model of Coronavirus Disease COVID-19 Cutting Edge Research
Authors: Gapat Sanket Santosh , Meshram Komal , Patil Praful 
Published: February 2022

COVID19 is a global pandemic spread to over 170 nations and regions. In virtually all nations impacted, the number of illnesses and fatalities has skyrocketed. Predictive approaches may be implemented to aid in developing improved plans and the making of sound judgments. These technologies analyze previous events to better anticipate what will occur in the future. These forecasts can aid in the planning of anticipated hazards and repercussions. In order to provide reliable projections, forecasting technology is critical. The prediction technology in this study is divided into two categories: random theoretical mathematical models and data science/machine learning technology. Forecasting relies heavily on data obtained from multiple platforms. Big data acquired from the World Health Organization/national database and social media communications were the two types of data sets examined in this study. The influence of environmental variables, the incubation time, the impact of isolation, age, gender, and other characteristics may all be used to forecast the pandemic. In this paper, the methodologies and factors utilized for prediction have been thoroughly examined. Forecasting technology, on the other hand, comes with its own set of difficulties (technical and general). This study examines these issues and offers a series of advice for those who are presently fighting the global COVID-19 epidemic.
Aim: Predictive Model of Coronavirus Disease COVID-19 Cutting Edge Research.
Conclusion: To get more accurate global forecasts, the models suggested in the literature must be evaluated on a worldwide scale. Multiple peaks should be included in the model for similar reasons, not just for short-term forecasting but also for anticipating outbreaks later this year. The study also highlighted the limitations of various prediction models and provided practical advice for dealing with the outbreak.
Effect of Neuro-Developmental Treatment versus Passive Stretching Exercises on Spastic Diplegic Cerebral palsy for Improving Posture: A Research Protocol
Authors: Parkhi Rutuja , Samal Snehal S. 
Published: February 2022

Background: Cerebral Palsy can be defined as a cluster of disorders acting on a person’s movement, posture, and balance. Cerebral Palsy, which affects 2 to 3 out of every 1000 live births, is caused by a variety of factors, including brain injury which can affect movement, posture, and balance. It’s linked to the perinatal period in about 92% of cases. Premature birth, perinatal infections, intrauterine growth restrictions, multiple gestations, and other risk factors are all factors to consider. This disorder prevents normal motor function Development. This protocol was developed to describe the design of an interventional study for the evaluation of the effect of Neuro-developmental treatment with conventional therapy and Passive Stretching with conventional therapy on improving posture in diplegic spastic Cerebral Palsy patients.
Methods: Participants (n=70) with spastic diplegic Cerebral Palsy who meet the included criteria will be hired for the study. Patients in group A will receive Neuro-Developmental treatment and conventional therapy, while patients in group B will receive Passive Stretching with conventional therapy. The Treatment protocol will last 6 weeks. Regular evaluations will take place. The Modified Ashworth Scale and the Gross Motor Function Classification System are going to be used to assess our progress.
Discussion: The intervention’s efficacy will be assessed by analyzing gross motor functions with the help of Gross Motor Function Classification System and spasticity level using Modified Ashworth Scale. Study and analysis will significantly support the use of Neuro-Developmental treatment with conventional therapy and Passive Stretching in conjunction with conventional therapy in Cerebral Palsy patients.
A Study Protocol on Assessment of Epidermal Growth Factor Receptor (EGFR) Signalling Pathway as a Predictive Molecular Marker in Triple-Negative Invasive Ductal Carcinoma of Breast
Authors: Vodithala Sahitya , Bhake Arvind 
Published: February 2022

Background: Breast cancer is the leading cause of cancer-related deaths worldwide. The Indian scenario is no different for the breast cancer mortality. Breast cancers have occupied the prominence not only for their incidence but the pace too. The researchers have studied numerous pathways vastly and widely in the past two decades to ascertain the prognosis and treatment outcome determinants popularly called predictive markers for breast cancer. One such cell signalling pathway that has raised the hope by assessing success for breast cancer is the Epidermal Growth Factor Receptor (EGFR) signalling pathway for a molecular subtype of Triple-Negative Breast Cancer (TNBC), which is challenging to treat therapeutically. This study aims to assess the EGFR pathway and its sub pathways in Triple-negative breast carcinoma (TNBC) and correlate the abnormalities of expressions in the EGFR pathway in TNBC for its therapeutic implications.
Materials and Methods: This will be an observational cross-sectional study. Forty cases of TNBC will be selected. There will be 10 cases each in 31-40 years, 41-50 years, 51-60 years, and 61 years onwards. Cases will undergo histological diagnosis of invasive ductal carcinoma, Immunohistochemistry for ER, PR, and Her2neu, IHC for EGFR, BRAF, Kras, and MAP kinase on histological sections, Polymerase chain reaction( PCR) for Kras. Data will be collected and analyzed using appropriate statistical tests.
Results: A significant correlation of EGFR, BRAF, KRAS, and MAP kinase is expected in the pathogenesis of triple-negative invasive ductal carcinoma.
Conclusion: The results can be put to the commercial advantage for clinical trials of the new drug development targeting anti-EGFR and other antibodies.
Case Report on Management of Abnormal Uterine Bleeding with Anemia
Authors: Raut Pallavi , Meshram Khushabu , Kolhekar Sonali , Sakharwade Prerana , Khandar Jaya , Pohekar Savita , Gujar Samruddhi 
Published: February 2022

Introduction: The most prevalent condition seen in the gynecology outpatient department is abnormal uterine bleeding (AUB). AUB can be caused by a variety of conditions 1. A 42 year female who have chief complaints of abnormal uterine bleeding is bleeding from the uterus that is longer than usual or that occurs at an irregular time. several characteristics of underlying hereditary or acquired blood disorders increase the "anticipated" hormonal imbalance at this age, hence worsening the morbidity of the underlying condition axis .Despite the fact that blood problems can cause AUB, uterine structural and/or endocrine abnormalities are frequently missed when a blood illness is present [1]. Hematologists and gynecologists, as well as adolescent medicine experts, must work to get her to treat a complex etiology [2,3].
Patient History: A 42 year old female was admitted in AVBRH in gynec ward sawangi meghe wardha with chief complaint of abnormal uterine bleeding since 2 month, abdominal pain since 1 week, weakness.
Medical Management: Patient treated with anticoagulant, antibiotic, iron supplement.
Nursing Management: Administrative IV fluid monitor vital sign, and medication given by doctor’s order.
Conclusion: Women should be asked about their previous menstrual cycle, regularity, desire for reproduction, contraception, and sexual health by their primary care providers. If abnormal uterine bleeding is detected at the primary care level, additional history, examination, and testing can be undertaken, and appropriate consultations can be scheduled. Timely treatment and management of abnormal uterine bleeding with anemia.
A Case Report on Pyloric Stenosis in Infants
Authors: Petkar Bhushan M. , Meshram Khushbu , Khandar Jaya , Kasturkar Pooja , Sakharwade Prerana , Tembhare Vaishali , Sakharkar Shital 
Published: February 2022

Introduction: Pyloric stenosis also known as pylorostenosis or specifically as infantile hypertrophic pyloric stenosis (IHPS) is the tapering (stenosis) of the opening from the stomach to the first part of the small intestine (duodenum). The term “pylorus” indicates “gate”. The thickened pylorus is feels as an olive shaped abnormal mass in the upper right hypochondriac and epigastrium region of the infant’s abdomen.
Clinical Findings: Frequent vomiting after feeding which is projectile,non-bilious, in nature. Continual hunger, dehydration, alterations in bowel movements, weight issues.
Diagnostic Evaluation: History collection (family history), physical examination (olive shaped mass) at epigastrium, hematological test (CBC), biochemistry test (KFT) (electrolyte imbalance). Ultrasonography (USG) abdomen:- thickened pylorus (<3mm), narrowed pyloric lumen, gastric content can not pass to duodenum, superior mesenteric artery and superior mesenteric vein located without altered position.
Therapeutic Interventions: Inj. Cefotaxim 1gm 1.4ml IV × BD (Antibiotics), Inj. Pantodex 40mg 2ml IV × OD (proton-pump-inhibitor), Inj. Temfix 100ml 50ml IV ×BD (antipyretic analgesic), IV Fluids.
Surgical Interventions: Fred-Ramstedt’s Pyloromyotomy.
Outcome: After treatment, infant show improvement. His frequent vomiting has been stopped and hunger problem resolved, baby starts gaining weight after surgery.
Conclusion: My patient was 1 month 10 days old when he was admitted to the paediatric intensive care unit (ICU) with the chief complaint of frequent vomiting, persistent hunger, weight loss, and dehydration. After a thorough physical examination and a variety of tests, he was diagnosed with infantile hypertrophic pyloric stenosis.
Ultra Violet and Visible Light as Therapeutic Tools for COVID-19
Authors: Masilamani V. , Shree R. Vidhya , Al-Saleh Wafa M , Courrol Lilia Coronato 
Published: February 2022

Covid-19 is a disease which has become pandemic because of transmission of the tiny, single stranded virus, called SARS-CoV-2 or SARS-2. It has infected so far 168 million people with a death toll of 3.6 million in 210 countries. The world has seen worse pandemics but this COVID 19 is the most widespread in the human history quite probably due to the global travels.
A few vaccines for this disease is still in different stages of trial and acceptance and there are only three ways of prevention: 1. Avoiding crowds, 2. Wearing a mask when you go out and 3 Keeping hands clean.
The contents presented in this article are the innovations that employ light as the fourth dimension of corona prevention and therapy. One can use UVC (at 222 nm from an excimer lamp or LED or the fourth harmonic of Nd YAG laser at 266nm) for direct irradiation on oral cavity; or visible light (450 nm from blue LED or white light from a handy mobile) for photodynamic action with curcumin (of common house hold turmeric) as the photo sensitizer. Both could work as therapeutic tools of significant potency.
A Case Report On: Guillain – Barre Syndrome
Authors: Hedau Ayushi , Sakharkar Sheetal , Ankar Ruchira , Raut Arati , Gujar Samrudhi , Dhengare Archna , Lokhande Shalini , Pande Khushbu , Sakharwade Prerna 
Published: February 2022

Introduction: Guillain berry syndrome is also called as landry’s paralysis. It is the disorder included in the peripheral neuropathy. In guillian berre syndrome, the patient’s body’s immune system attacks on the nerves. This condition may also triggered by the bacterial infections as well as some of the viral infections. GBS is a rare syndrome approximately there were only 1-2 cases per 1,00000 people annually. Men are more likely affected than that of womens. This syndrome is names after a French physicion Gorgous Guillian and Jean Alxzandre Barre and strohl who described it in 1916.
Clinical Findings: weakness, difficulty in breathing, difficult to hold the breath till 5 second, fatigue, elevated blood pressure, difficulty in speaking.
Pheripheral Smear: RBCS _ normal range, atrophy is seen.
Ultrasonography: Enlargement of vagus nerve.
Therapeutic Interventions: DNS 380 ml intravenous, plasma exchange theraphy, inj. Ceftriaxone, syrup Phenytoyin 9.5 ml. syrup rdpen 10 ml. syp calcimax 10 ml, tab folic acid 5 mg, tab limcee 500 mg, tab baclofenac 10 mg, NEB 3% NACL, inj pantop 15 mg.
Outcomes: After the treatment, the child shows improvement. His weakness and fatigue ger relieved and pain in muscle had relieved.
Conclusion: A 5 years old male child was admitted in the prdiatric ward no. 18 , Acharya Vinoba Bhave Rural Hospital on date 31 july 2021 with a case of Guillian Barre Syndrome (GBS). He had the complaint of weakness, fatigue, lack of co-ordination, difficulty in swallowing .After getting an appropriate treatment, the patient’s condition has improved than that of previous.
Managing Phase Orientation and Crystallinity of Printed Dion–Jacobson 2D Perovskite Layers via Controlling Crystallization Kinetics
Authors: Chen Yijun , Hu Jinlong , Xu Zhenhua , Jiang Zhengyan , Chen Shi , Xu Baomin , Xiao Xiudi , Liu Xianhu , Forberich Karen , Brabec Christoph J. , Mai Yaohua , Guo Fei 
Published: February 2022

AbstractTwo‐dimensional perovskites have attracted substantial attention for solar cell applications because of their higher stability as compared to their 3D analogs. To achieve efficient charge transport in thin‐film devices, obtaining high crystalline perovskite crystals perpendicularly aligned to the substrate is of great importance. This article reports the scalable printing of high‐quality Dion–Jacobson (DJ) perovskite thin films via tailoring crystallization kinetics. Introducing a small amount of 1‐methyl‐2‐pyrrolidinone to the conventional N,N‐dimethylformamide:dimethyl sulfoxide‐based precursor, the strong coordination with ammonium spacers enables a notably retarded crystallization, which results in perovskite films with distinctly enhanced crystallinity, highly vertical orientation, and graded phase distribution. Accordingly, efficient charge generation and ultrafast interphase charge transfer are realized. The champion DJ perovskite device delivers a high current density of 17.10 mA cm–2, an impressive open‐circuit voltage of 1.21 V, leading to a stabilized efficiency of 16.19%. In addition, the devices processed from the ternary solvent exhibit remarkably improved stability under stimuli with light, heat, and humidity, benefiting from their superb phase stability. This work demonstrates an important advancement in scalable deposition of DJ perovskite thin films for efficient and stable photovoltaic devices.
Hints for a General Understanding of the Epitaxial Rules for van der Waals Epitaxy from Ge‐Sb‐Te Alloys
Authors: Arciprete Fabrizio , Boschker Jos Emiel , Cecchi Stefano , Zallo Eugenio , Bragaglia Valeria , Calarco Raffaella 
Published: February 2022

AbstractIn this study, a generalized guideline is identified to predict the interaction between two‐dimensional (2D) layered materials and substrate surfaces. Additionally, the van der Waals (vdW) heterostructures commensurability, the phase formation and the strain relaxation are identified during interface growth. To achieve such a general overview, the case of Ge‐Sb‐Te (GST) alloys on InAs(111) is studied. In this system, low‐lattice mismatch conditions are fulfilled to avoid relaxation due to formation of misfit dislocations and allow to correctly identify vdW epitaxy. At the same time, the substrate can be efficiently prepared into self‐ and un‐passivated surfaces to clarify the role of the surface interaction. Furthermore, the GST epilayer exhibits two different highly ordered 2D structures and a three‐dimensional disordered structure, allowing to directly infer the nature of the epitaxy. This study opens the way for the design and mastering of vdW epitaxial growth of 2D heterostructures as well as hybrid 2D and non‐layered materials.
Role of Fiber Thickness and Surface Treatment of Electrospun Polycaprolactone Matrices on the Growth of Different Breast Cancer‐Associated Cells
Authors: Sivakumar Sankaranarayanan , Schmid Rafael , Wieland Annalena , Strissel Pamela L. , Strick Reiner , Fischer Lena , Thievessen Ingo , Kataev Elmar , Arkudas Andreas , Horch Raymund E. , Schubert Dirk W. , Kengelbach‐Weigand Annika 
Published: February 2022

AbstractCancer models mimicking the tumor microenvironment are necessary to successfully develop and predict responses of oncological drugs. In this study, electrospun polycaprolactone (PCL) matrices are tested for the development of an in vitro breast cancer model. The effects of fiber thickness and plasma‐treatment of the matrices on in vitro growth of breast cancer‐associated cells, namely breast cancer cells MDA‐MB‐231, primary adipose‐derived stem cells (ADSCs) and primary endothelial progenitor cells (EPCs) are evaluated. Surface treatment of the matrices by air‐plasma leads to increased oxygen/carbon ratio and hydrophilicity. WST‐8 analysis reveals that the proliferation of all three cell types increased exponentially over 12 d on all matrices. MDA‐MB‐231 and ADSC show a higher proliferation on nanofibers due to enhanced cellular adhesion compared to microfibers. In contrast, EPCs show a significantly higher proliferation on microfibers than on nanofibers at day 12 which can further be significantly improved by air‐plasma treatment. Cross‐sectioning analysis shows that cells grow on the surface of nanofibers, while microfibers have considerable cellular infiltration. These findings suggest that the electrospun PCL matrices are a suitable tool for the development of breast cancer models containing several cell types, which can ultimately lead to designing novel tumor therapies.
Domain‐Engineered Flexible Ferrite Membrane for Novel Machine Learning Based Multimodal Flexible Sensing
Authors: Shen Lvkang , Liu Ming , Lu Lu , Ma Chunrui , Jiang Changjun , You Caiyin , Zhang Jiaheng , Zhao Weiwei , Geng Li , Jia Chun‐Lin 
Published: February 2022

AbstractFlexible materials and devices that can simultaneously reflect multimodal information are highly desired for novel flexible electronics and intelligent flexible sensing systems. In this regard, flexible magnetic films have great potential for wireless multimodal flexible sensor due to the curvature and azimuth angle‐dependent ferromagnetic resonance. However, a key challenge now is to build the precise relationship among the mechanical bending, azimuth angle, and the ferromagnetic resonance of the film, which involves multi‐physics and coupled process. In this work, the physical problem is solved by combining material engineering and machine learning. Material domain engineering is applied to form localized multi‐peak ferromagnetic resonance features for increasing sensitivity. Besides, convolutional neural network algorithm is utilized to help recognize the bending and azimuth angle modulated ferromagnetic resonance in flexible film systems. It is found that the bending information for the flexible film with engineered domain structure can be mapped to the ferromagnetic profile with accuracy over 99%, while the accuracy sharply decreases to less than 50% in the control group of high‐quality film. This study provides a versatile platform for developing machine learning‐based novel sensing materials.