bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bean Yellow Mosaic and Tomato Ringspot Virus Influence on Growth and Elemental Content of ‘Dark Red Kidney’ Bean (Phaseolus vulgaris L.)1
Authors: Fries R. E. , Bergman E. L. , Boyle J. S. 
Published: August 2022

Abstract
Greenhouse nutrient cultures with lx and 2x modified Hoagland solutions were used to study the influence of bean yellow mosaic and tomato ringspot virus isolates on elemental content of plant parts of ‘Dark Red Kidney’ beans. All isolates reduced fresh and dry wt of plants. Plants grown in 2x solution were somewhat smaller than those treated with lx solution.
Solutions increased in pH and conductivity but decreased in volume. Control solution volumes decreased more while pH’s and conductivities increased more than those of comparable solutions containing virus-infected plants. Control plants absorbed more total P, K, Ca, Mg, Mn, and B from the solutions than inoculated ones.
Both increases and decreases in nutrient content of bean plants resulted from virus infection, higher concentrations and total amount of Mn in virus-infected plant parts and a possible association between plant K level and the amounts of water absorbed by roots was observed. Interpretation of elemental content has to be based on virus and/or isolate, plant part sampled, time of sampling, nutrient solution concentration and element.
A Review on Recent Advancement in Expression Strategies Used in
Bacillus subtilis
Authors: Ejaz Sharoon , Khan Hamza , Sarwar Nadia , Aqeel Sahibzada Muhammad , Al-Adeeb Abdulqader , Liu Song 
Published: August 2022

Abstract:
Bacillus subtilis is a Gram-positive bacterium that has gained an unprecedented reputation as an expression system at the industrial scale due to characteristics such as GRAS (Generally recognized as safe), ease of genetic manipulation, high growth rate on the cheap substrate, and short fermentation cycle. This expression system has been widely accepted for the production of various chemicals, pharmaceutical products, food products, proteins, and enzymes. But there are various hurdles to optimized production of heterologous protein in this expression system due to a lack of understanding regarding metabolic pathways and expression elements. In this review, we have emphasized strategies that can enhance the expression level of heterologous proteins in B. subtilis. These strategies included optimization of B. Subtilis strain, expression elements such as promotors, UTR (Untranslated region), RBS (Ribosome binding site), signal peptide, and metabolic pathways. Finally, contemporary challenges and future perspectives of B. subtilis as an industrial scale expression system were discussed.
Appraising the Phytochemical and Therapeutic Perspectives of Bryonia
laciniosa: A Literature Metasynthesis
Authors: Katiyar Deepti , Saxena Rashmi , Kumar Abhishek , Prakash Surya , Bhardwaj Abhay , Bansal Priya 
Published: August 2022

Background:
Nature has bestowed mother Earth with an array of herbals utilized as
therapeutics for various human ailments since the origin of life. Bryonia laciniosa (family: Cucurbitaceae)
is one such herb, which finds its mention in various traditional systems of medicine and
has attracted current researchers due to its significant therapeutic value.

Objective:
The current article aims to present a literature metasynthesis on Bryonia laciniosa.

Method:
The authors performed scholarly searches for peer-reviewed findings on Bryonia laciniosa
and incorporated all the data related to the phytochemical and therapeutic profile of the drug.

Results:
This compilation comprises of Phytochemical and Pharmacological profile of Bryonia
laciniosa elaborating its traditional significance and recent researches related to its biological activities.
The plant exhibits its potential as an antimicrobial, anti-inflammatory, analgesic, antipyretic,
anticonvulsant, anti-asthmatic, anticancer, antioxidant, antidiabetic, and aphrodisiac agent. It also
displays its benefits in wound healing and ulcerative colitis.

Conclusion:
The presence of flavonoids, saponins, terpenoids, anthocyanins, coumarins, alkaloids,
polyphenols, tannins and emodins in this plant is responsible for its various pharmacological activities.
The retrospective study provides direction for existing research as well as future studies to
support the domain of pharmaceutical and medical sciences.
The Research Trends and Scientometric Assessment of Rheumatoid Arthritis in India During 2016-2021
Authors: Garg Anuj , Garg Rajat 
Published: August 2022

Abstract:
Rheumatoid arthritis (RA) is a chronic autoimmune disorder that affects the synovial
joints, causing swelling and joint damage. RA has become a major public health concern, harming
more than 1500 people per lakh of the world's population. This inflammatory disorder is more
common in females in comparison to males (3:1). In the present work, a scientometric analysis of
published articles on RA during the last five years [1st January 2016 to 2021] on 19/08/2021 in the
Scopus database is performed and investigates the contribution of India. In this study, the top most
productive countries and the contribution of India in this field were analyzed. The different journals,
funding agencies, and productive authors from India who contributed to this field are also recognized.
The average citation impact is 10 citations per paper. A total of 61% share was found for the
International collaboration in India’s publication on rheumatoid arthritis. In India's output on rheumatoid
arthritis, medicine produced the largest percentage of paper (60 percent). The top 15 journals
publishing the maximum number of Indian papers contribute 1% share of global rheumatoid
arthritis research (The highest number of papers (95 papers) published by the Indian Journal of
Rheumatology). During the period 2016-2021, the top 10 highly cited papers got a total of 7045 citations,
averaging 705 citations per publication. India was found to have a 5% (1974 publications)
share of global output (42312 publications). In conclusion, there is a small number of researches on
rheumatoid arthritis in a country, which holds the 2nd position in population across the world. There
is a need for more research on rheumatoid arthritis in India.
Novel Anti-amoebic Properties of Agarophytes Gracilaria changii and
Gracilaria salicornia Extracts
Authors: Goh Tiong-Keat , Yow Yoon-Yen , Anwar Ayaz , Khan Naveed Ahmed , Ong Seng-Kai 
Published: August 2022

Introduction:
Acanthamoeba is a ubiquitous and parasitic protozoan capable of causing serious human infections, resulting in blindness and even death. Seaweeds are abundant and widely known for their antimicrobial properties. This study aims to unveil the anti-amoebic potential of two Malaysian red seaweeds, Gracilaria changii and Gracilaria salicornia on Acanthamoeba castellanii.

Methods:
Water, methanol and ethyl acetate extracts of G. changii and G. salicornia were tested against A. castellanii. Liquid chromatography-mass spectrometry (LC-MS) analysis was carried out to identify the compounds responsible for the anti-amoebic effect.

Results:
Methanol extract of G. salicornia showed a significant growth inhibition of 22 % in A. castellanii trophozoites. Cytotoxicity of these extracts were shown to be minimal in human keratinocyte cells through cell viability assay.

Conclusion:
Data from LC-MS revealed fourteen compounds with reported biological activities. These findings suggest the use of G. changii and G. salicornia as potential sources of anti-amoebic compounds.
The Perceived Effectiveness of Secure Messaging for Medication Reconciliation During Transitions of Care: Semistructured Interviews With Patients
Authors: Brady Julianne E , Linsky Amy M , Simon Steven R , Yeksigian Kate , Rubin Amy , Zillich Alan J , Russ-Jara Alissa L 
Published: August 2022

Background
Medication discrepancies can lead to adverse drug events and patient harm. Medication reconciliation is a process intended to reduce medication discrepancies. We developed a Secure Messaging for Medication Reconciliation Tool (SMMRT), integrated into a web-based patient portal, to identify and reconcile medication discrepancies during transitions from hospital to home.

Objective
We aimed to characterize patients’ perceptions of the ease of use and effectiveness of SMMRT.

Methods
We recruited 20 participants for semistructured interviews from a sample of patients who had participated in a randomized controlled trial of SMMRT. Interview transcripts were transcribed and then qualitatively analyzed to identify emergent themes.

Results
Although most patients found SMMRT easy to view at home, many patients struggled to return SMMRT through secure messaging to clinicians due to technology-related barriers. Patients who did use SMMRT indicated that it was time-saving and liked that they could review it at their own pace and in the comfort of their own home. Patients reported SMMRT was effective at clarifying issues related to medication directions or dosages and that SMMRT helped remove medications erroneously listed as active in the patient’s electronic health record.

Conclusions
Patients viewed SMMRT utilization as a positive experience and endorsed future use of the tool. Veterans reported SMMRT is an effective tool to aid patients with medication reconciliation. Adoption of SMMRT into regular clinical practice could reduce medication discrepancies while increasing accessibility for patients to help manage their medications.

Trial Registration
ClinicalTrials.gov NCT02482025; https://clinicaltrials.gov/ct2/show/NCT02482025
Prediction of VO2max From Submaximal Exercise Using the Smartphone Application Myworkout GO: Validation Study of a Digital Health Method
Authors: Helgerud Jan , Haglo Håvard , Hoff Jan 
Published: August 2022

Background
Physical inactivity remains the largest risk factor for the development of cardiovascular disease worldwide. Wearable devices have become a popular method of measuring activity-based outcomes and facilitating behavior change to increase cardiorespiratory fitness (CRF) or maximal oxygen consumption (VO2max) and reduce weight. However, it is critical to determine their accuracy in measuring these variables.

Objective
This study aimed to determine the accuracy of using a smartphone and the application Myworkout GO for submaximal prediction of VO2max.

Methods
Participants included 162 healthy volunteers: 58 women and 104 men (17-73 years old). The study consisted of 3 experimental tests randomized to 3 separate days. One-day VO2max was assessed with Metamax II, with the participant walking or running on the treadmill. On the 2 other days, the application Myworkout GO used standardized high aerobic intensity interval training (HIIT) on the treadmill to predict VO2max.

Results
There were no significant differences between directly measured VO2max (mean 49, SD 14 mL/kg/min) compared with the VO2max predicted by Myworkout GO (mean 50, SD 14 mL/kg/min). The direct and predicted VO2max values were highly correlated, with an R2 of 0.97 (P<.001) and standard error of the estimate (SEE) of 2.2 mL/kg/min, with no sex differences.

Conclusions
Myworkout GO accurately calculated VO2max, with an SEE of 4.5% in the total group. The submaximal HIIT session (4 x 4 minutes) incorporated in the application was tolerated well by the participants. We present health care providers and their patients with a more accurate and practical version of health risk estimation. This might increase physical activity and improve exercise habits in the general population.
El empleo de las radiaciones ionizantes y no ionizantes en el tratamiento de aguas residuales contaminadas con benzodiacepinas
Authors: Manduca Artiles Michel , Gaspard Sarra , Jauregui Haza Ulises 
Published: August 2022

En el presente trabajo se realizó una búsqueda bibliográfica sobre la presencia de las benzodiacepinas en las aguas residuales y potables, debido a la ineficiencia de las plantas de tratamiento de residuales líquidos, y sus posibles incidencias en los organismos acuáticos. Por otra parte, se estudió el empleo de tres procesos avanzados de oxidación (PAOs) (radiación UV, ultrasonido de alta frecuencia y la radiación gamma) y su combinación con los agentes oxidantes H2O2 y el reactivo de Fenton para la degradación de los fármacos de tipo benzodiacepínico, haciendo un especial énfasis en el diazepam y el midazolam. Se reportaron niveles de notificación en los cuerpos de agua desde 9,5 ng L-1 hasta 1 μg L-1. De los PAO estudiados, el más empleado fue la radiación UV, con un 90-100 % de degradación a las dos horas de tratamiento. El ultrasonido de alta frecuencia fue el proceso menos empleado en la degradación de las benzodiacepinas. En el caso de la radiación gamma, a pesar de sus elevados porcentajes de degradación a dosis entre 2500 Gy y 5000 Gy, el uso de este proceso ha sido limitado por las regulaciones que implican. Para los tres PAOs en estudio, su combinación con los agentes oxidantes H2O2 y el reactivo de Fenton supuso una mejora significativa en la eficiencia de degradación para los fármacos pertenecientes a la familia de las benzodiacepinas.
Spatio-Temporal Analysis of Dengue Cases in Kuningan District Since 2008-2017
Authors: Fuadiyah M. Ezza Azmi , Ruliansyah Andri 
Published: August 2022

Dengue has spread to over 400 of Indonesia’s 497 districts, including West Java Province in which 26 of its districts have been declared as hyper-endemic. A study was conducted to describe the spread of dengue incidences and its cluster during 2008-2017 in Kuningan District. The district is located in an important route, in migration and in the economic field, connecting the northern part of West Java to the southern part. A spatio-temporal analysis based on monthly dengue incidences from the local District Health Office was performed using SaTScan™. This study revealed there were Statistically significant high-risk dengue clusters with various RR in half of the subdistricts in Kuningan in the ten-year periods of 2008-2017 and a retrospective space-time analysis detected 17 significant clusters (P<0.001). Subdistrict Kuningan is detected as a high-risk area every year except for 2008, whereas Jalaksana emerged as a high-risk cluster in six of ten-year periods. We conclude that there was a dynamic spread of dengue cases initiated from the north part of Kuningan District to western areas. This study results do not properly predict RR due to a lack of information on some significant factors, such as vector density and related environmental and socioeconomic parameters. However, this study has provided a perspective on dengue incidence that can be used by local health managers and disease surveillance personnel to monitor prospective outbreaks and make decisions about how to implement an effective response.
Bioactive composition and TLC profile data on Pax Herbal Malatreat Tea
Authors: Owolabi Tunde , Osaretin Dominion , Eyinayan Blessing 
Published: August 2022

The biological/pharmacological activities of any herbal drug are determined by the bioactive components contained in the plant(s) used in its formulation, these substances are greatly affected by the quality control system adopted during and after production processes and handling of such product. Thin Layer Chromatography is one of such quality control parameters that demonstrate uniqueness and uniformity between various substances, thus serving as an identity for such products. Pax Herbal Malatreat tea is a polyherbal drug used in the management and treatment of malaria symptoms. This study evaluated the different phytoconstituents present and developed fingerprint profiles (TLC) for the drug (Pax Herbal Malatreat Tea) to serve as a quality control check during the production consistency and market uniqueness. Qualitative phytochemical and chromatographic analyses were carried out using standard methods. The qualitative test revealed the presence of Tannin, Flavonoid, Saponin, Steroids, Reducing sugar, and Terpenoids, and the finger-print chromatograms after development with chloroform-ethyl acetate (9.5:05) showed five distinct components at 365 nm and four spots when sprayed with 20% methanolic sulphuric acid and viewed under visible light. From this present report, an identity card has been developed for the drug (Pax Herbal Malatreat Tea) via bioactive composition and TLC profiles which can be used in accessing the quality and consistency of the product.
The Use of Whatsapp as A Communication Medium in English Learning
Authors: Hawaijana Ikfina , Warnindah  
Published: August 2022

This study aims to determine the use of WhatsApp as a communication medium in learning English. This research was carried out at SMK N 1 Kawunganten with the object of the research are XI and XII grade from TKR department and English teachers in this school. Nowadays, social media is very easy to be accessed by smartphone users anywhere, anytime and in any activity. If viewed more specifically, currently there are types of social networks that have special features such as direct messages known as chat, voice features, even image or photo upload service features at social network users who also have the application. WhatsApp is one of the applications that are very popular and most downloaded in most of people. In the part of education ,WhatsAppis known as the most widely used online media between students and teachers or students and lecturers. The benefit of using WhatsApp ijn short made online learning is easier, the example is providing information about learning, materials, communication between students and teachers or students and lecturers, both personal and group, and even be used as a learning evaluation media. The method that we use in this study is a qualitative research with data collection techniques are interviews and observation. The first step we conduct interview with three of the English teachers in this schools. The next step we plan an observation used WhatsApp group. Based on the data we got a result that WhatsApp application was chosen because it has a practical and appropriate side to be used in SMK N 1 Kawunganten during learning from home. In conclusion, WhatsApp is suitable to be used as a communication medium in English learning at SMK N 1 Kawunganten
PENINGKATAN SELF-REGULATED DAN BERPIKIR KRITIS MATEMATIKA MELALUI MODEL PEMBELAJARAN TREFFINGER
Authors: Kusniawati Ita , Vahlia Ira , ES Yeni Rahmawati 
Published: August 2022

ABSTRAK
Tujuan dari penelitian ini adalah untuk meningkatkan self-regulated dan berpikir kritis matematika melalui model pembelajaran treffinger pada siswa kelas VII-5 SMP N 1 Sekampung. Jenis penelitian ini adalah penelitian tindakan kelas dengan subyek penelitian adalah siswa kelas VII-5 SMP N 1 Sekampung yang terdiri dari 32 siswa. Berdasarkan hasil penelitian dan pembahasan, terlihat adanya peningkatan self-regulated dan berpikir kritis matematika siswa pada pembelajaran yang dilakukan. Hal ini dapat diketahui dari peningkatan persentase keempat aspek yaitu kesadaran akan tanggung jawab belajar dengan persentase 75,56% menjadi 85,63%, kesadaran akan tanggung jawab belajar dengan persentase 76,67% menjadi 86,21%, kontinuitas belajar dengan persentase 75,74% menjadi 85,34%, dan keaktifan belajar dengan persentase 73,57% menjadi 85,22%. Untuk hasil berpikir kritis matematika dapat diketahui dari peningkatan keempat indikator yaitu elementary clarification 24,38% dengan kategori sangat rendah menjadi 62,50% dengan kategori sedang, keterampilan memberikan penjelasan lanjut 36,67% dengan kategori sangat rendah pada menjadi 85,45% dengan kategori sangat tinggi, keterampilan mengatur strategi dan taktik 36,56% dengan kategori sangat rendah menjadi 81,79% dengan kategori sangat tinggi, dan keterampilan menyimpulkan 14,69% dengan kategori sangat tinggi menjadi 91,81% dengan kategori sangat tinggi.
Kata Kunci: berpikir kritis; model pembelajaran treffinger; self-regulated

ABSTRACT
The purpose of this study is to improve self-regulated and critical thinking mathematics through treffinger learning models in students of class VII-5 SMP N 1 Sekampung. This type of research is a classroom action research study subjects were students of class VII-5 SMP N 1 Sekampung consisting of 32 students. Based on the results of the research and discussion, an increase in self-regulated and critical thinking of mathematics is seen in students' learning. This can be seen from the increase in the percentage of the four aspects, namely awareness of learning responsibilities with a percentage of 75.56% to 85.63%, awareness of learning responsibilities with a percentage of 76.67% to 86.21%, continuity of learning with a percentage of 75.74% to 85.34%, and learning activeness with a percentage of 73.57% to 85.22%. For the results of critical thinking mathematics can be seen from the increase in the four indicators namely elementary clarification 24.38% with very low categories to 62.50% with moderate categories, skills to provide further explanation 36.67% with very low categories at 85.45% with very high category, skills to set strategy and tactics 36.56% with very low categories to 81.79% with very high categories, and skills concluded 14.69% with very high categories to 91.81% with very high categories.
Keywords: critical thinking; self-regulated; treffinger learning models
PENINGKATAN AKTIVITAS DAN KEMAMPUAN BERHITUNG PECAHAN MELALUI MODEL PEMBELAJARAN STAD BERBANTUAN KOMIK
Authors: Tugiyem Tugiyem 
Published: August 2022

ABSTRAK
Tujuan penelitian ini adalah untuk mengetahui peningkatkan aktivitas belajar dan kemampuan berhitung pecahan siswa melalui model pembelajaran Student Team Achievement Division (STAD) berbantuan komik pada pembelajaran Matematika materi operasi hitung pecahan. Jenis penelitian adalah penelitian tindakan kelas. Penelitian ini dibagi dalam 2 siklus yaitu siklus I dan siklus II yang masing-masing terdiri dari 3 pertemuan. Populasi penelitian berjumlah 31 siswa dengan distribusi siswa laki-laki 12 siswa dan siswa perempuan 19 siswa. Sampel penelitian menggunakan sampel jenuh. Teknik dan pengumpulan data yang dilakukan dengan cara pengisian lembar observasi selama proses tindakan penelitian oleh supervisor sehingga akan diperoleh data kualitatif sebagai hasil penelitian. Teknik analisis data menggunakan analisis deskriptif komparatif dengan membandingkan nilai tes antar siklus dilihat dari indikator kinerja. Hasil penelitian menunjukkan adanya peningkatkan aktivitas belajar dan kemampuan berhitung pecahan siswa kelasVI SDN Kaliwadas 01 semester I tahun pelajaran 2018/2019. Hal tersebut dapat dilihat pada perubahan yang signifikan dari siklus I dan siklus II. Hasil belajar siswa mengalami peningkatan dari yang semula hanya 68% pada siklus I menjadi 94% pada siklus II.
Kata kunci: aktivitas; kemampuan berhitung pecahan; komik; STAD

ABSTRACT
The purpose of this study was to determine the increase in learning activities and the ability to count fractions of students through the learning model of Student Team Achievement Division (STAD) assisted by comics in mathematics learning in fraction counting operations material. This type of research is classroom action research. This research was divided into 2 cycles, namely cycle I and cycle II, each of which consisted of 3 meetings. The study population consisted of 31 students with a distribution of 12 male students and 19 female students. The research sample used saturated samples. Techniques and data collection are done by filling out the observation sheet during the research action process by the supervisor so that qualitative data will be obtained as a result of the research. The data analysis technique used a comparative descriptive analysis by comparing the test scores between cycles seen from the performance indicators. The results showed that there was an increase in learning activities and the ability to count fractions of Grade VI students at SDN Kaliwadas 01 semester I of the 2018/2019 academic year. This can be seen in the significant changes from cycle I and cycle II. Student learning outcomes have increased from 68% in the first cycle to 94% in the second cycle.
Keywords: STAD; comics; activity; fraction counting ability