bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal association between maternal psychological stress during pregnancy and infant neurodevelopment: The moderating effects of responsive caregiving
Authors: Shi Yuyang , Zhang Yudi , Wei Qian , Ma Xuemei , Zhang Yunhui , Shi Huijing 
Published: November 2022

BackgroundLittle is known regarding the role of responsive caregiving in the association between maternal psychological stress and child neurodevelopment. We, therefore, herein investigated the relationship between maternal psychological stress during pregnancy and children's neurodevelopment with modifications in responsive caregiving.MethodsA total of 3,603 mother–child pairs were recruited from the Shanghai Maternal-Child Pairs Cohort, and we assessed maternal psychological stress using the Life Events Scale for Pregnant Women (LESPW) during early and late pregnancy. Early neurodevelopment of infants at 6 and 12 months of age was also evaluated using the Age and Stage Questionnaire, Third Edition (ASQ-3). The 2-month-old infant nursing-care questionnaire was designed based on the Five Elements of Parenting Care Framework released by the World Health Organization (WHO) and used to evaluate the levels of early responsive caregiving for infants. Multivariate logistic regression analysis was then applied to determine the association between maternal psychological stress during pregnancy and child development.ResultsThe suspected developmental delay rate of infants aged 6 and 12 months ranged between 13.3% and 24.5%. After adjusting for confounders, we noted that high maternal subjective events stress during early pregnancy was associated with an increased risk of suspected developmental delay in problem-solving domains at 12 months of age [adjusted OR (aOR) = 1.51; 95% confidence interval (CI), 1.09–2.20]. High general negative objective events’ stress during late pregnancy also constituted a risk factor for development in the personal–social domain at 12 months of age (aOR = 1.57; 95% CI, 1.13–2.19). Remarkably, we noted in infants with insufficient responsive caregiving that there were greater associations between the risk of general maternal negative objective events during late pregnancy and personal–social domain at 12 months of age (aOR = 2.06; 95% CI, 1.15–3.68). Similarly, there was a greater association between the risk for maternal subjective events during early pregnancy and problem-solving at 12 months of age (aOR = 1.55; 95% CI, 1.11–2.34).ConclusionsMaternal psychological stress during pregnancy was predominantly associated with suspected developmental delay in infants at 6 and 12 months of age, and these associations were modified by early responsive caregiving.
Treatment of olecranon fractures in childhood: A systematic review
Authors: De Maio Fernando , Gorgolini Giulio , Caterini Alessandro , Luciano Claudia , Covino Dario , Farsetti Pasquale 
Published: November 2022

BackgroundLiterature over the last 20 years provides evidence for a surgical treatment of displaced olecranon fractures in children, this is usually obtained with commonly proposed methods, although there is no general agreement about the best recommended technique.AimIdentifying the best surgical technique in displaced olecranon fractures in children and the role of associated fractures in the prognosis of these lesions, by analyzing the most relevant studies on this topic.MethodsA literature search was performed in MEDLINE database and Scopus database. Articles reporting clinical outcomes of pediatric patients affected by olecranon fractures treated surgically were identified.ResultsThe initial search produced 111 studies, with 8 fulfilling the eligibility criteria of our study. Selected articles (2002–2022) included 122 patients overall.ConclusionDisplaced olecranon fractures, occurring during skeletal growth and surgically treated, generally have good results, although we are unable to recommend the best surgical treatment based on our review. In most cases, they are intra-articular fractures; thus, the overall goal is to get an anatomic reduction that in some cases cannot be obtained by percutaneous techniques. Tension band suture is the preferred device, although it is not recommended in adolescence for the high risk of fixation failure. Associated lesions may affect results.
Identification of a novel pyridine derivative with inhibitory activity against ovarian cancer progression in vivo and in vitro
Authors: Si Lulu , Lai Tianjiao , Zhao Junru , Jin Yuxi , Qi Meng , Li Mingyue , Fu Hanlin , Shi Xiaojing , Ma Liying , Guo Ruixia 
Published: November 2022

Ovarian cancer is the second leading cause of death of female gynecological malignant tumor patients worldwide. Although surgery and chemotherapy have achieved dramatic achievement, the mortality remains high, resulting in the demand for new specific drug discovery. Disrupting ovarian cancer growth via histone deacetylase (HDAC) inhibition is a strategy for cancer therapy or prevention. In this work, we synthesized a novel pyridine derivative named compound H42 and investigated its anti-cancer activity in vivo and in vitro. We found that compound H42 inhibited ovarian cancer cell proliferation with IC50 values of 0.87 μM (SKOV3) and 5.4 μM (A2780). Further studies confirmed that compound H42 induced apoptosis, intracellular ROS production, and DNA damage. Moreover, compound H42 downregulated the expression of histone deacetylase 6 (HDAC6) with a distinct increase in the acetylation of α-tubulin and heat shock protein 90 (HSP90), followed by the degradation of cyclin D1, resulting in cell cycle arrest at the G0/G1 phase. Importantly, ectopic expression of HDAC6 induced deacetylation of HSP90 and α-tubulin, while HDAC6 knockdown upregulated the acetylation of HSP90 and α-tubulin. However, in the nude xenograft mouse study, compound H42 treatment can inhibit ovarian cancer growth without obvious toxicity. These findings indicated that compound H42 inhibited ovarian cancer cell proliferation through inducing cell cycle arrest at the G0/G1 phase via regulating HDAC6-mediated acetylation, suggesting compound H42 could serve as a lead compound for further development of ovarian cancer therapeutic agents.
Dual-targeted repetitive transcranial magnetic stimulation modulates brain functional network connectivity to improve cognition in mild cognitive impairment patients
Authors: Zhang Xinqi , Ren Huixia , Pei Zian , Lian Chongyuan , Su XiaoLin , Lan Xiaoyong , Chen Chanjuan , Lei YuHua , Li Baima , Guo Yi 
Published: November 2022

Background: Mild cognitive impairment (MCI) is a condition between normal aging and dementia; nearly 10–15% of MCI patients develop dementia annually. There are no effective interventions for MCI progression. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique that has attempted to improve the overall cognitive function of MCI patients. However, it does not affect episodic memory improvement.Methods: In this study, we engaged 15 clinically diagnosed MCI patients and normal controls to explore the effect of dual-targeted rTMS on progressing cognitive function, particularly episodic memory in MCI patients. Resting-state EEG recordings and neuropsychological assessments were conducted before and after the intervention. EEG features were extracted using an adaptive algorithm to calculate functional connectivity alterations in relevant brain regions and the mechanisms of altered brain functional networks in response to dual-target rTMS.Results: The study revealed that the functional brain connectivity between the right posterior cingulate gyrus (PCC) and the right dorsal caudate nucleus (DC) was significantly reduced in MCI patients compared to normal controls (p &lt; 0.001). Dual-target rTMS increased the strength of the reduced functional connectivity (p &lt; 0.001), which was related to cognitive enhancement (p &lt; 0.05).Conclusion: This study provides a new stimulation protocol for rTMS intervention. Improving the functional connectivity of the right PCC to the right DC is a possible mechanism by which rTMS improves overall cognitive and memory function in MCI patients.
Complex response inhibition and cognitive flexibility in school-aged Cypriot-Greek-speaking children who stutter
Authors: Paphiti Maria , Jansson-Verkasalo Eira , Eggers Kurt 
Published: November 2022

PurposeOver the last few years, research findings have suggested limitations in executive function (EF) of children who stutter (CWS) with the evidence being more consistent in studies with preschoolers (3–6  years old) than in studies with school-aged children (6–12  years old). The purpose of the current study was to assess complex response inhibition and cognitive flexibility in school-aged CWS and their non-stuttering peers.MethodsParticipants, 19 CWS (mean age = 7.58  years, range 6.08–9.17) and 19 age-and gender-matched children who do not stutter (CWNS; mean age = 7.58  years, range 6.08–9.33), completed a visual task consisting of three task blocks. Analyses were based on response times and error percentages during the different task blocks.ResultsAll participants showed expected performance-costs in task block comparisons targeting complex response inhibition and cognitive flexibility. Significant group differences were found in measures of cognitive flexibility with CWS performing slower compared to CWNS (p = 0.02). Additionally, significant block × group interactions demonstrated that CWS, compared to CWNS, slowed down more (i.e., higher performance-cost) under both complex response inhibition (p = 0.049) and cognitive flexibility task conditions (p = 0.04 for no-set-shifting and p = 0.02 for set-shifting).ConclusionThese results are in line with some of the previous findings in school-aged CWS and suggest that CWS present lower performance in complex response inhibition and cognitive flexibility task conditions when compared to their non-stuttering peers.
Comparison of craniofacial morphology in individuals with and without hypodontia with a special focus on the number of congenitally missing teeth
Authors: Fekonja Anita , Čretnik Andrej 
Published: November 2022

BackgroundHypodontia might negatively affect dental function and esthetics, what might affect patients' self-esteem, communication behavior, professional performance and thus quality of life. The aim of this study was to estimate the influence of number of congenital missing teeth on dentofacial features.MethodsLateral cephalograms of 60 individuals with hypodontia (study group) and 40 individuals without hypodontia (control group) were analyzed. Patients in the study group were divided into two subgroups according to the number of missing teeth (group A with hypodontia 1 to 4 teeth and group B with hypodontia 5 or more teeth). Cephalometric data were compared among the study and control groups and statistically analyzed.ResultsThe results in the present study revealed a significantly shorter and more retrognathic maxilla, more prognathic chin position, more retruded incisors in both jaws, large interincisal angle, straighter facial convexity as well as more retruded upper and lower lips in the group B compared with the control group. In the group A only chin position was significantly more prognathic compared with the control group.ConclusionsAccording to the results of present study impact of hypodontia on the craniofacial morphology and consequently on facial esthetics was found statistically significantly greater in patients with 5 or more congenitally missing teeth.
Neighborhood social capital and self-rated mental health: Disparities between migrants and native residents in Beijing
Authors: Wang Xiaomeng , Zhou Peiling , Liu Zhilin 
Published: November 2022

IntroductionAlthough the impact of neighborhood social capital on mental health has long been recognized, the extent to which the impact differs between immigrants and local residents remains a puzzle. This study aims to bridge the gap by comparing internal migrants who are restricted by their household registration (hukou) status, and urban natives in China.MethodsUsing self-rated mental health and social capital survey data collected in 26 neighborhoods in Beijing, this study examines the mental health outcomes of three types of neighborhood social capital, including social networks, shared norms and mutual trust, and social support.ResultsThe study finds that the hukou status of immigrants moderates the effect of neighborhood social capital on mental health, and that the internal migrants in China experience less mental health benefit of neighborhood social capital than urban natives. Compared with urban natives, neighborhood social networks have less positive effect on migrants' mental health than that of urban natives.ConclusionThe findings suggest that policy makers can improve the mental health of migrants through social capital building on the premise of eliminating the restrictions of hukou system on the migrants' right to participate in neighborhood activities and to access neighborhood services.
Differences in mortality in Switzerland by citizenship during the first and second COVID-19 waves: Analysis of death statistics
Authors: Plümecke Tino , Mikosch Heiner , Mohrenberg Steffen , Supik Linda , Bartram Isabelle , Ellebrecht Nils , zur Nieden Andrea , Schnieder Laura , Schönberger Hannah , Schulze-Marmeling Charlotte , Gutzeit Andreas 
Published: November 2022

BackgroundEarly in the COVID-19 pandemic, it became apparent that members of marginalized populations and immigrants were also at risk of being hospitalized and dying more frequently from COVID-19. To examine how the pandemic affected underserved and marginalized populations, we analyzed data on changes in the number of deaths among people with and without Swiss citizenship during the first and second SARS-CoV-2 waves.MethodWe analyzed the annual number of deaths from the Swiss Federal Statistical Office from 2015 to 2020, and weekly data from January 2020 to May 2021 on deaths of permanent residents with and without Swiss citizenship, and we differentiated the data through subdivision into age groups.ResultsPeople without Swiss citizenship show a higher increase in the number of deaths in 2020 than those who were Swiss citizens. The increase in deaths compared to the previous year was almost twice as high for people without Swiss citizenship (21.8%) as for those with it (11.4%). The breakdown by age group indicates that among people between the ages of 64 and 75, those without Swiss citizenship exhibited an increase in mortality (21.6%) that was four times higher than that for people with Swiss citizenship (4.7%).ConclusionThis study confirms that a highly specialized health care system, as is found in Switzerland, does not sufficiently guarantee that all parts of the population will be equally protected in a health crisis such as COVID-19.
Consumo de alimentos industrializados em diabéticos acompanhados em ambulatório
Authors: Duarte Giovana Santos Simões , Souza Laís Alves Vieira de , Santos Maria Heloísa Lira Rodrigues dos , Lopes Melissa Moser de Araújo , Gonçalves Fabiana Cristina Lima da Silva Pastich , Costa Andressa Marília Tavares , Santos Thaís Manuella Moraes dos , Burgos Maria Goretti Pessoa de Araújo 
Published: November 2022

A dieta ocidental, caracterizada pela alta densidade calórica, e o sedentarismo, são os principais fatores que aumentam o risco para as doenças crônicas não transmissíveis, como a obesidade e a diabetes mellitus tipo 2. Esse tipo de dieta engloba alimentos ricos em gorduras saturadas, açúcar e sódio, que são características dos alimentos industrializados, estando cada vez mais presentes na rotina da população. O objetivo deste trabalho é identificar as mudanças na frequência de consumo de alimentos processados e ultraprocessados, em diabéticos, durante o acompanhamento nutricional. Estudo é transversal alinhada a uma coorte retrospectiva, com Diabéticos tipo 2 maior ou igual a 60 anos, no ambulatório de nutrição/diabetes, do Núcleo de Atenção ao Idoso, da Universidade Federal de Pernambuco, atendidos no período de 2013 a 2019. Foram analisadas variáveis sociodemográficas (sexo e idade, procedência), clínicas (hipertensão arterial sistêmica e dislipidemia), de estilo de vida (prática de atividade física e etilismo), antropométricas (peso e altura) e dietética (recordatório de 24 horas). Foram estudados 230 pacientes, na faixa de 60 a 74 anos (83%), com tempo de doença de 1-5 anos (36,5%), sexo feminino (80%), procedentes da Região Metropolitana do Recife (70%), com presença de hipertensão arterial sistêmica (81,7%), dislipidemia (62,2%) e excesso de peso (59,1%). A prática de atividade física e o etilismo não foram predominantes. Os pacientes foram acompanhados durante 3 consultas, com período de 6 meses entre elas. Ocorreu variação no consumo de grupos de alimentos entre a 1ª e a última consulta de nutrição, com redução significativa de embutidos (8,3%) e de pão (18,3%), enquanto aumentou o consumo de frutas (29,5%) e raízes (6,5%). A frequência de consumo de alimentos industrializados no grupo de diabéticos foi alta nos dois momentos avaliados, com redução significativa após o acompanhamento nutricional, que evidenciou efeitos positivos na qualidade da alimentação do paciente.
Correlação entre comprometimentos sensório-motores e qualidade de vida em indivíduos após o Acidente Vascular Encefálico
Authors: França Isadora Rodrigues de , Borges Mariana Bee , Gomes Milena Almeida Costa , Almeida Maria Beatriz Cardoso de , Andrade Giovana Frazon de , Bini Ana Carolina Dorigoni , Teixeira Jociane de Lima , Lopes Josiane 
Published: November 2022

O acidente vascular encefálico (AVE) constitui uma alteração da circulação encefálica que ocasiona um déficit transitório ou definitivo no funcionamento de uma ou mais partes do encéfalo, podendo ser classificado em isquêmico ou em hemorrágico. É uma das principais causas de incapacidade no mundo todo, caracteriza uma condição que pode incapacitar o indivíduo em suas funções físicas, sensoriais, perceptuais, autonômicas e/ou cognitivas que pode impactar na qualidade de vida. Objetivo: Correlacionar os comprometimentos sensório-motores e qualidade de vida em indivíduos após o AVE. Metodologia: Foi realizado um estudo transversal com amostra composta de indivíduos com diagnóstico de AVE atendidos na clínica-escola de Fisioterapia da UNICENTRO. Os indivíduos foram avaliados por meio de questionário sócio-clínico e os instrumentos Mini Exame do Estado Mental, Protocolo de Desempenho Físico de Fugl-Meyer e Escala de Qualidade de Vida Específica para AVE (EQVE-AVE). Resultados: A amostra avaliada foi de 22 indivíduos (13 homens e 9 mulheres) com diagnóstico de AVE, apresentando prevalência do AVE isquêmico. A média do escore do instrumento EQVE-AVE foi de 145,15 ± 43,86 e os domínios da escala Fugl-Meyer que evidenciaram maior comprometimento foram energia, memória e concentração, personalidade e papeis familiares. Não houve correlacão entre comprometimento sensório-motor e qualidade de vida. Conclusão: A amostra apresentou um alto score de qualidade de vida e comprometimentos sensório-motores considerados marcantes. Não houve correlação entre os comprometimentos sensório-motores e a qualidade de vida dos indivíduos após o AVE.
Oculopatia pós síndrome de Stevens-Johnson: relato de caso
Authors: Andrade Larissa Martins Vieira de , Alves Isabella Tavares , Souza Kamilla Menezes e , Nunes Thaís Gonçalves , Pôrto Stéfano Vasconcelos , Romão Júlia Veloso , Alves Murilo Zupelli Rodrigues , Mendonça Victória de Paula 
Published: November 2022

A síndrome de Stevens-Johnson (SSJ) caracteriza-se por um processo imunológico que cursa com febre autolimitada, lesões mucocutâneas inflamatórias podendo, também, apresentar comprometimento ocular. Uma das suas etiologias pode ser decorrente de reação adversa a algum tipo de medicamento. No acometimento da superfície ocular a doença pode se manifestar por uveíte anterior, entrópio, xeroftalmia, inflamação conjuntival persistente e cicatrização de conjuntiva.
Effectiveness Online Learning at Biology Subject in Student’s Perception at Senior High School at Muko Muko
Authors: Irwandi Irwandi , Hartati Merri Sri , Lestari Puji Dwi 
Published: November 2022

The Indonesian government tried to made many policies in covid – 19 pandemic. For example, Social distancing in big Scale (PSBB), Work From Home (WFH) and other policy in all of aspect included of education. So that learning activity did by internet online in many platforms. This research aimed to knew how to student’s perception and effectiveness in online learning at Biology Subject in Senior High schools at Ipuh, Muko - Muko. The types of research was Qualitative descriptive that described student’s perception in used whatsApp at Biology Learning by online. The data collection technique in this study used a questionnaire. This data was description about student’s perception toward used WhatsApp in Biology learning as learning media in covid – 19 pandemic. Its data was took from observation, Questionnaire and interview. Data was taken by Google form application and shared in Whatsapp group. Its Data was analyzed by descriptive. The conclusion of this research was student’s perception in biology learning by using WhatsApp as media during the Covid 19 pandemic showed negative respons.
Exploring Student Attitudes during Physical Education Class
Authors: Kurniawan Ari Wibowo , Kurniawan Rama , Sari Devi Kumala 
Published: November 2022

This study aimed to assess the student's attitude in attending physical, sports, and health education. The observed attitude involved their attitude of religion, honesty, discipline, responsibility, politeness, caring (tolerance-mutual cooperation), and confidence. The research was conducted using non-experimental quantitative analysis. This study involved 296 students in SMP Negeri 9 Malang City that consisted of 93 students from class VII, 100 students from class VIII, and 103 students from class IX. The data were collected through observation, self-assessment sheets, and peer-assessment sheets. Research instruments were analyzed using validity and reliability analysis. From the results of the validity analysis, 15 statements were declared valid. The results of the reliability analysis, the observation guide, self-assessment sheet, and peer-to-peer assessment sheet attained reliability scores of 0.788, 0.790, and 0.811. to obtain research results, analysis using percentages is carried out by researchers. The study results show that students' attitudes are generally classified as excellent with a great culture. Besides, attention and support from the surrounding environment are observed to be very influential for the student's attitude. Stakeholders should facilitate students to develop their behavior and attitudes.