bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climate advocacy among Italian pediatric pulmonologists: A national survey on the effects of climate change on respiratory allergies
Authors: Lauletta Marcella , Moisé Erika , La Grutta Stefania , Cilluffo Giovanna , Piacentini Giorgio , Ferrante Giuliana , Peroni Diego G. , Di Cicco Maria 
Published: January 2022

AbstractClimate change (CC) is expected to negatively impact respiratory health due to air pollution and increased aeroallergen exposure. Children are among the most vulnerable populations due to high ventilation rates, small peripheral airways, and developing respiratory and immunological systems. To assess the current knowledge among Italian pediatric pulmonologists on the potential effects of CC on pediatric respiratory allergic diseases, a national survey was launched online from February 2020 to February 2021. The members of the Italian Pediatric Respiratory Society (SIMRI) were contacted by email and 117 questionnaires were returned (response rate 16.4%). 72.6% of respondents were females, 53.8% were academic pediatricians, 42.7% had been working >10 years. Most of the participants were aware of the potential health effects of CC and stated that they had noticed an increase in the incidence (90.6%) and severity (67.5%) of allergic respiratory diseases among their patients. About 61% and 41% of participants respectively felt that there had been an increase in the number of children sensitized to pollen and molds. When applying latent class analysis to identify the features characterizing participants with greater awareness and knowledge of CC‐related health effects, two classes were identified: almost 60% of the participants were labeled as “poor knowledge” and those with greater awareness were older, had longer work experience, and were those using the Internet to gather information about CC. There is urgent need to increase pediatricians' awareness of the detrimental effects of CC on children's respiratory health and integrate them in the educational programs of healthcare professionals.
Age‐dependent phenotypes of ovarian endometriomas
Authors: Benagiano Giuseppe , Guo Sun‐Wei 
Published: January 2022

AbstractPurposeTo analyze the characteristics of the ovarian endometrioma (OE) across the life span of a woman. In the past, the OE has traditionally been viewed as a single, monolithic disease. Today, there are emerging data indicating that OE phenotypes differ according to the age of the woman.MethodA narrative review of original articles on OE indexed by PubMed.ResultsWhen appearing in infancy and early adolescence, OE may be the consequence of endometrial cells retrogradely shed with neonatal uterine bleeding. The post‐menarcheal variant, manifesting itself during full adolescence, is singularly frequent in the presence of vaginal or uterine outflow obstructive anomalies. The typical and most frequent adult phenotype is characterized by increasing fibrosis and a tendency to progress; its mere presence exerts a detrimental effect on the surrounding healthy ovarian tissue. In postmenopause, an old lesion may be reactivated in the presence of exogenous or endogenous estrogens, or even be produced ex novo; rarely, it can spread to a variety of organs and structures and even degenerate causing malignancies.ConclusionsGiven the existence of these variants, it is important to agree on management guidelines that take into consideration these different phenotypes.
Investigation on the Effect of Highly Active Ni/ZrO2 Catalysts Modified by MgO‐Nd2O3 Promoters in CO2 Methanation at Low Temperature Condition
Authors: Liu Zhiru , Ding Xin , Zhu Rong , Li Yanan , Wang Yuqi , Sun Wen , Wang Di , Wu Le , Zheng Lan 
Published: January 2022

AbstractTo improve the catalytic activity of CO2 methanation at low reaction temperature, four Ni‐based precursors with different auxiliaries were prepared by sol‐gel composite impregnation method. The CO2 methanation of the catalysts after hydrogen reduction were tested in a fixed bed quartz reactor at 200–450 °C. The properties of the catalysts were further characterized by BET, XRD, H2‐TPD, CO2‐TPD, H2‐TPR, XPS, SEM, TGA and TEM‐EDS. The Ni‐based catalysts followed an activity order of Ni‐MgO‐Nd2O3/ZrO2>Ni‐MgO/ZrO2>Ni‐Nd2O3/ZrO2>Ni/ZrO2, especially at temperatures below 400 °C. By establishing the correlation between the catalytic performance and structure of the catalyst, it was found that the mixing of Mg, Nd and Ni metal ions in the ZrO2 lattice results in high dispersion of Ni nanoparticles and good interaction between metal oxides. The composite doped Ni‐based catalysts show good catalytic performance and stability for CO2 methanation.
Deconstruction of Poplar Wood using Peracetic Acid and FeCl3 in Hot Water
Authors: Zhou Yongcai , Zhan Peng , Tong Denghui , Zhang Weifeng , Qing Yan , Huang Yilei , Zhang Lin , Chen Jienan 
Published: January 2022

AbstractThe deconstruction of lignocellulose biomass is a key step in biorefinery that requires directional control and high efficiency. Peracetic acid and FeCl3 were adopted in this study during hot water pretreatment, so that the directional deconstruction of poplar wood was enhanced, boosting the subsequent separation of hemicellulose and enzymatic hydrolysis of the remaining biomass, avoiding the necessity of employing high temperature and pressure. A hemicellulose removal (as in xylan) of 98.23 % was achieved. The pretreatment conditions were: 5.7 w/v% peracetic acid, 0.05 mol L−1 FeCl3, 100 °C for 60 min; the results obtained were: 88.63 % hemicellulose removal (as in xylan), 73.38 % cellulose recovery rate, and 85.92 % cellulose enzymatic saccharification rate. The structure, crystallinity, morphology, and surface chemistry of samples were analyzed by scanning electron microscopy, Fourier transform infrared spectroscopy, X‐ray diffraction, and X‐ray photoelectron spectroscopy. The results showed that efficient pretreatment and cellulose enzymatic saccharification could be achieved under moderate pretreatment conditions, promising good potential in biomass conversion.
Size Selective Corona Interactions from Self‐Assembled Rosette and Single‐Walled Carbon Nanotubes
Authors: Gong Xun , Shuai Liang , Beingessner Rachel L. , Yamazaki Takeshi , Shen Jianliang , Kuehne Matthias , Jones Kelvin , Fenniri Hicham , Strano Michael S. 
Published: January 2022

AbstractNanoparticle corona phases, especially those surrounding anisotropic particles, are central to determining their catalytic, molecular recognition, and interfacial properties. It remains a longstanding challenge to chemically synthesize and control such phases at the nanoparticle surface. In this work, the supramolecular chemistry of rosette nanotubes (RNTs), well‐defined hierarchically self‐assembled nanostructures formed from heteroaromatic bicyclic bases, is used to create molecularly precise and continuous corona phases on single‐walled carbon nanotubes (SWCNTs). These RNT–SWCNT (RS) complexes exhibit the lowest solvent‐exposed surface area (147.8 ± 60 m−1) measured to date due to its regular structure. Through Raman spectroscopy, molecular‐scale control of the free volume is also observed between the two annular structures and the effects of confined water. SWCNT photoluminescence (PL) within the RNT is also modulated considerably as a function of their diameter and chirality, especially for the (11, 1) species, where a PL increase compared to other species can be attributed to their chiral angle and the RNT's inward facing electron densities. In summary, RNT chemistry is extended to the problem of chemically defining both the exterior and interior corona interfaces of an encapsulated particle, thereby opening the door to precision control of core–shell nanoparticle interfaces.
Uncertainty handling in cyber–physical systems: State‐of‐the‐art approaches, tools, causes, and future directions
Authors: Asmat Mah Noor , Khan Saif Ur Rehman , Hussain Shahid 
Published: January 2022

AbstractCyber–Physical System (CPS) is the set of heterogeneous physical units linked to a network and performs complex operations to achieve a goal. Uncertainty increases with the increase in complexity of CPS. Thus, uncertainty needs to be mitigated to assure the quality and reliability of a CPS. This study aims to identify current state‐of‐the‐art approaches, tools, root causes, and metrics for uncertainty in the domain of CPS. We performed a systematic literature review and employed keyword‐based search on publisher sites to find potential studies. After applying the devised inclusion and exclusion criteria on identified potentially relevant studies, selection of studies is validated using an index engine. The core contributions of this study are (i) to categorize the tools used for uncertainty mitigation and existing root causes of uncertainty in CPS domain, (ii) to categorize the tools used for uncertainty mitigation and existing root causes of uncertainty in CPS domain, and (iii) to identify the state‐of‐the‐art methods that lack the ability to elaborate the metrics to measure the uncertainty in CPS. The results of the proposed study are beneficial in guiding future research on devising new approaches or tools to mitigate the causes of uncertainty in CPS.
Factors affecting students' learning from a design‐based implementation research project in diverse education systems
Authors: Lin Qinyun , Frank Kenneth A. , Bathia Shruti , Draney Karen , Thomas Jay , Anderson Charles W. 
Published: January 2022

AbstractThis article reports on quantitative findings from a design‐based implementation research (DBIR) project Carbon TIME that focused on teaching carbon cycling at multiple scales, from atomic‐molecular to global. We report results from a large dataset from diverse schools, including 59,654 student assessments of three‐dimensional learning aligned with Next Generation Science Standards collected in classrooms of 133 middle‐ and high‐school teachers over a 4‐year period. We used a subset of these data to investigate factors related to students' learning in this large and diverse set of classrooms. Our findings included: First, Carbon TIME's curriculum and professional development were associated with substantial improvements in overall student achievement; within classrooms students with lower pretest scores had higher learning gains. Second, differences among individual teachers accounted for more of the variance in student learning gains than other measures including school demographics and students' prior knowledge. Third, school demographic factors (percent free and reduced lunch and percent marginalized students of color) had statistically significant but small effects on students' learning. Finally, sustained investment and participation were important; student learning gains improved across years for the project as a whole, and for individual teachers as they gained experience and participated in professional development. These findings contribute to programs of systemic changes to support three‐dimensional science learning.
Transverse momentum dependent operator expansion at next-to-leading power
Authors: Vladimirov Alexey , Moos Valentin , Scimemi Ignazio 
Published: January 2022

Abstract
We develop a method of transverse momentum dependent (TMD) operator expansion that yields the TMD factorization theorem on the operator level. The TMD operators are systematically ordered with respect to TMD-twist, which allows a certain separation of kinematic and genuine power corrections. The process dependence enters via the boundary conditions for the background fields. As a proof of principle, we derive the effective operator for hadronic tensor in TMD factorization up to the next-to-leading power (∼ qT/Q) at the next-to-leading order for any process with two detected states.
Accessing the influence of 99mTc-Sesta-MIBI-positive thyroid nodules on preoperative localisation studies in patients with primary hyperparathyroidism
Authors: Hargitai Lindsay , Schefner Maria , Traub-Weidinger Tatjana , Haug Alexander , Arikan Melisa , Scheuba Christian , Riss Philipp 
Published: January 2022

Abstract
Purpose
Curative treatment for primary hyperparathyroidism (PHPT) is parathyroidectomy (PTX) with removal of the hyperfunctioning gland(s). In an endemic goitre region, 35–78% of PHPT patients show concomitant thyroid disease. This study aimed to evaluate if 99mTc-sestamibi (MIBI)-positive thyroid nodules decrease sensitivity in regard to localising the hyperfunctioning parathyroid gland(s) in PHPT patients.

Methods
Within 5 years, 497 consecutive patients with biochemically proven PHPT were included in this study. The data was analysed retrospectively.

Results
In total, 198 patients underwent PTX with thyroid surgery and 299 patients underwent sole PTX. Sensitivity of MIBI scan for PTX with and without thyroid surgery was 72.1% and 73.6%, respectively. A statistically significant difference in sensitivity of ultrasound for PTX with and without thyroid surgery (57.0% and 70.9%, respectively) was observed (p = 0.029). Thyroid nodule histology did not have a significant effect on the MIBI scan. Unilateral neck exploration (UNE) was performed in 110 patients and bilateral neck exploration (BNE) in 177 patients. The probability of surgical conversion from UNE to BNE due to incorrect localisation was 1.733 times higher in patients with thyroid nodules.

Conclusions
Concomitant benign thyroid nodules did not influence MIBI sensitivity. No correlation between thyroid carcinoma and MIBI uptake was determined. However, MIBI detection of thyroid malignancy is important in patients initially being considered for minimal invasive parathyroidectomy. Sensitivity and positive predictive value of ultrasound were significantly lower in patients with thyroid nodules. The probability of conversion from UNE to BNE due to incorrect localisation was 1.733 times higher in patients with thyroid nodules.
Rekonstruktion des Druckpotenzials für den unteren Grundwasserleiter im Münsterländer Kreidebecken im Falle eines ungehinderten Grubenwasseranstiegs im Grundgebirge
Authors: Ottenjann Maj-Britt , Kons Sandra , Meßer Johannes , Werner Florian , Getta Michael , Göbel Patricia 
Published: January 2022

ZusammenfassungIm Münsterländer Kreidebecken (NRW & Niedersachsen, Deutschland) wird für das im gesamten Becken verbreitete untere Grundwasserleitersystem der Schichten des Cenomans und Turons (Untere Oberkreide) ein hydraulischer Druckausgleich zwischen dem Nord- und Südrand angenommen. Für den Fall eines ungehinderten Grubenwasseranstiegs im Grundgebirge (Karbon) würde sich in diesem Grundwasserleitersystem eine hydraulische Druckpotenzialfläche ausbilden („worst-case“-Szenario), welche sich ausgehend von hydrogeologisch begründbaren, hydraulischen Druckpunkten am Nord‑, Ost und Südrand des Beckens über das Beckeninnere aufspannen lässt. Die auf den potenziellen hydraulischen Druckpunkten des Beckens basierende und mittels ArcGIS interpolierte Druckpotenzialfläche weist ein generelles Gefälle nach Westen mit ihrem höchstgelegenen Druckpunkt im Nordosten (Fosbergquelle bei Bielefeld) und ihrem niedrigsten Druckpunkt im Südwesten (Ruhrbogen in Oberhausen) auf. Die Druckpotenzialfläche ist zukünftig für die „worst-case“-Betrachtung von Grubenwasseranstiegsszenarien in stillgelegten Bergwerken oder von aufsteigenden Tiefengrundwässern in oberflächennahe Grundwasserleitersysteme verwendbar.
Computational analysis of the tryptophan cation radical energetics in peroxidase Compound I
Authors: Poulos Thomas L. , Kim Jenny S. , Murarka Vidhi C. 
Published: January 2022

AbstractThree well-characterized heme peroxidases (cytochrome c peroxidase = CCP, ascorbate peroxidase = APX, and Leishmania major peroxidase = LMP) all have a Trp residue tucked under the heme stacked against the proximal His heme ligand. The reaction of peroxidases with H2O2 to give Compound I results in the oxidation of this Trp to a cationic radical in CCP and LMP but not in APX. Considerable experimental data indicate that the local electrostatic environment controls whether this Trp or the porphyrin is oxidized in Compound I. Attempts have been made to place the differences between these peroxidases on a quantitative basis using computational methods. These efforts have been somewhat limited by the approximations required owing to the computational cost of using fully solvated atomistic models with well-developed forcefields. This now has changed with available GPU computing power and the associated development of software. Here we employ thermodynamic integration and multistate Bennett acceptance ratio methods to help fine-tune our understanding on the energetic differences in Trp radical stabilization in all three peroxidases. These results indicate that the local solvent structure near the redox active Trp plays a significant role in stabilization of the cationic Trp radical.
Graphical abstract
Immune checkpoint inhibitor–associated myocarditis
Authors: Osinga T. E. , Oosting S. F. , van der Meer P. , de Boer R. A. , Kuenen B. C. , Rutgers A. , Bergmann L. , Oude Munnink T. H. , Jalving M. , van Kruchten M. 
Published: January 2022

AbstractImmune checkpoint inhibitors (ICIs) are increasingly recognised to effectuate long-lasting therapeutic responses in solid tumours. However, ICI therapy can also result in various immune-related adverse events, such as ICI-associated myocarditis, a rare but serious complication. The clinical spectrum is wide and includes asymptomatic patients and patients with fulminant heart failure, making it challenging to diagnose this condition. Furthermore, the optimal diagnostic algorithm and treatment of ICI-associated myocarditis is unknown. In this review, we describe two cases on both ends of the spectrum and discuss the challenges in recognising, diagnosing and treating ICI-associated myocarditis.
Een marketingreflectie op Snacks and the City
Authors: van Ittersum Koert 
Published: January 2022

SamenvattingIk heb met bijzonder veel interesse en waardering het artikel ‘Snacks and the City’ gelezen, waarin een veldonderzoek wordt beschreven om gezond snacken te promoten. Wat een mooi en waardevol experiment en wat geweldig om hier als hoogleraar Marketing en Consumentenwelzijn vanuit een marketingperspectief op te mogen reflecteren.
Naar een integraal alcoholbeleid in België
Authors: Kramer Ruben , De Donder Else , de Duve Martin , Van Havere Tina , Geirnaert Marijs , Matthys Frieda , Decorte Tom 
Published: January 2022

SamenvattingDe alomtegenwoordigheid en sociale aanvaarding van alcohol in België verbloemt in vele gevallen de schadelijke gevolgen die alcohol heeft. Om die gevolgen te reduceren, is er de afgelopen jaar veel onderzoek gedaan naar de effectiviteit van mogelijke overheidsmaatregelen. Onder andere de Wereldgezondheidsorganisatie adviseert landen over effectieve beleidsmaatregelen op basis van wetenschappelijke inzichten. Ondanks de aanbevelingen van de Wereldgezondheidsorganisatie en uit wetenschappelijke onderzoeken is er in België nog altijd geen sprake van een nationaal alcoholbeleidsplan waarin deze maatregelen integraal zijn opgenomen. Maatregelen op het vlak van preventie, hulpverlening, prijs, aanbod en marketing zijn noodzakelijk om de schadelijke gevolgen van alcohol effectief te reduceren.
Bespreekbaar maken van gezonde leefstijl en het sociale netwerk bij multiprobleemgezinnen door sociaal werkers
Authors: Nagelhout Gera , Abidi Latifa , Lodder Cynthia , Schutte Hermijn , de Vries Hein 
Published: January 2022

SamenvattingIn dit onderzoek keken we naar factoren die het bespreekbaar maken van het belang van een gezonde leefstijl en het sociale netwerk door sociaal werkers bij cliënten uit multiprobleemgezinnen kunnen bevorderen of belemmeren. We voerden kwalitatieve interviews uit onder veertien sociaal werkers uit Apeldoorn. Bevorderende factoren waren vooral organisatorisch van aard. Sociaal werkers ontvingen in deze periode regelmatig reminders om het belang van een gezonde leefstijl en het sociale netwerk te bespreken (via e‑mails, nieuwsbrieven en tijdens teambesprekingen), wat een belangrijke bevorderende factor bleek te zijn. Het sociale netwerk werd standaard al besproken door sociaal werkers, maar de leefstijl niet altijd. Het is voor sociaal werkers makkelijker om het belang van een gezonde leefstijl of het sociale netwerk te bespreken wanneer de cliënt hierover een hulpvraag heeft. Wanneer de cliënt duidelijk ongezond leeft of een leefstijlgerelateerde aandoening heeft, maakt dat het ook makkelijker om leefstijl te bespreken. Voor veel sociaal werkers werkte het belemmerend dat de leefstijl en het sociale netwerk geen prioriteit hebben boven urgentere problematiek. De meeste andere belemmerende factoren waren gerelateerd aan de cliënt, bijvoorbeeld dat de cliënt midden in een crisissituatie zit, zelf geen probleem ervaart, weerstand heeft ten opzichte van de hulpverlening of dat de cliënt een verstandelijke beperking of ernstige psychiatrische problematiek heeft, of ernstig verslaafd is.
De lessen die de zorg kán en móét leren van de COVID-19-pandemie
Authors: Westra Daan , Tietschert Maike 
Published: January 2022

SamenvattingDe COVID-19-pandemie stelt zorgorganisaties voor grote uitdagingen. Hoewel specifieke aspecten prominenter zijn in bepaalde sectoren van de zorg, staan alle zorgorganisaties voor de opgave om de randvoorwaarden te organiseren waarbinnen zorgprofessionals zo veel mogelijk mensen zo goed mogelijk kunnen helpen. Vanuit managementperspectief vallen vier grote thema’s op in de manier waarop zorgorganisaties hiermee omgaan. Op de eerste plaats proberen zorgorganisaties met man en macht hun personeel inzetbaar te houden. Daarnaast worden er verschillende digitale oplossingen geïmplementeerd en wordt er op ongekende schaal en snelheid samengewerkt met organisaties binnen en buiten de zorg. Dit gebeurt in directe interactie met landelijk en regionaal beleid, dat als last of lust ervaren wordt. Om goed door de coronacrisis te komen en de zorg op een duurzame manier te organiseren in het ‘nieuwe normaal’ na de crisis, is het essentieel dat de lessen en best-practices van dergelijke initiatieven systematisch getrokken en verspreid worden.
Gezonde School: landelijke samenwerking voor een gezonde jeugd
Authors: van Koperen Marije , Kruitwagen Vivian , Westhuis Arianne , Sobels Martijn 
Published: January 2022

SamenvattingOnderwijs maakt deel uit van de samenleving en bereidt leerlingen voor op participatie in de samenleving. Het stimuleren van een gezonde leefstijl bij leerlingen vormt een belangrijke maatschappelijke opdracht voor het onderwijs. Een gezonde leefstijl draagt immers bij aan het goed doorlopen van de schoolcarrière, een goede start van het werkend bestaan en op lange termijn een gezonder en langer leven. Scholen in het basis-, voortgezet- en middelbaar beroepsonderwijs kunnen met behulp van het nationale programma Gezonde School integraal en structureel werken aan een gezonde leefstijl, zodat een gezonde leefstijl op school vanzelfsprekend wordt. Samenwerking met landelijke thema- en kennis instituten, het onderwijs en de overheid is hierbij noodzakelijk, evenals de ondersteuning van GGD’en.
Werken vanuit plekken in het echte leven
Authors: Lettinga Ant , Slagter Martian , Merkelijn Ellis , Meijering Louise 
Published: January 2022

SamenvattingHet ideaal van zelfredzaamheid staat steeds meer ter discussie. Terwijl het bedoeld is om mensen in staat te stellen meer verantwoordelijkheid voor eigen leven en welbevinden te nemen, verwordt het vaak tot een instrument dat professionele hulp terugbrengt tot een drietal vragen: ‘Wat kun je zelf doen?’, ‘Hoe kan je netwerk helpen’ en ‘Wat heb je van mij als professional nodig?’ Wat hierbij gemist wordt, is dat levens van mensen in kwetsbare situaties nogal overweldigend kunnen zijn. Meer greep op het eigen leven krijgen is dan juist de onuitgesproken hulpvraag. Daartoe presenteren wij een breder sociaal-ruimtelijk raamwerk, dat levens van mensen begrijpt vanuit plekken waar ze graag zijn, waren en naartoe willen. Ervaringen van mensen die na hersenletsel hun leven weer willen oppakken, dienen hierbij als voorbeeld.