bluuebunny/crossref_metadata_2025_split huggingface dataset:
Verifiable strategy synthesis for multiple autonomous agents: a scalable approach
Authors: Gu Rong , Jensen Peter G. , Poulsen Danny B. , Seceleanu Cristina , Enoiu Eduard , Lundqvist Kristina 
Published: March 2022

AbstractPath planning and task scheduling are two challenging problems in the design of multiple autonomous agents. Both problems can be solved by the use of exhaustive search techniques such as model checking and algorithmic game theory. However, model checking suffers from the infamous state-space explosion problem that makes it inefficient at solving the problems when the number of agents is large, which is often the case in realistic scenarios. In this paper, we propose a new version of our novel approach called MCRL that integrates model checking and reinforcement learning to alleviate this scalability limitation. We apply this new technique to synthesize path planning and task scheduling strategies for multiple autonomous agents. Our method is capable of handling a larger number of agents if compared to what is feasibly handled by the model-checking technique alone. Additionally, MCRL also guarantees the correctness of the synthesis results via post-verification. The method is implemented in UPPAAL STRATEGO and leverages our tool MALTA for model generation, such that one can use the method with less effort of model construction and higher efficiency of learning than those of the original MCRL. We demonstrate the feasibility of our approach on an industrial case study: an autonomous quarry, and discuss the strengths and weaknesses of the methods.
Acute Stress Reaction in Combat: Emerging Evidence and Peer-Based Interventions
Authors: Adler Amy B. , Gutierrez Ian A. 
Published: March 2022

Abstract
Purpose of Review
This paper highlights the topic of combat-related acute stress reactions (ASRs) in service members. Specifically, we contrast ASRs with related psychiatric conditions, report the estimated prevalence of ASRs for soldiers deployed to combat, and discuss how team members can effectively respond to these reactions.

Recent Findings
Although not regarded as a clinical disorder, ASRs can have a significant impact on high-risk occupations like the military in which impaired functioning can imperil team members and others. Based on self-report, 17.2% of soldiers who have deployed to combat report having experienced a possible ASR. To our knowledge, this is the first such prevalence estimate.

Summary
The prevalence of ASRs underscores the need for improved prevention, management, and recovery strategies. Peer-based intervention protocols such as iCOVER may provide a useful starting point to address ASRs in team members.
Tragic Choices and the Virtue of Techno-Responsibility Gaps
Authors: Danaher John 
Published: March 2022

AbstractThere is a concern that the widespread deployment of autonomous machines will open up a number of ‘responsibility gaps’ throughout society. Various articulations of such techno-responsibility gaps have been proposed over the years, along with several potential solutions. Most of these solutions focus on ‘plugging’ or ‘dissolving’ the gaps. This paper offers an alternative perspective. It argues that techno-responsibility gaps are, sometimes, to be welcomed and that one of the advantages of autonomous machines is that they enable us to embrace certain kinds of responsibility gap. The argument is based on the idea that human morality is often tragic. We frequently confront situations in which competing moral considerations pull in different directions and it is impossible to perfectly balance these considerations. This heightens the burden of responsibility associated with our choices. We cope with the tragedy of moral choice in different ways. Sometimes we delude ourselves into thinking the choices we make were not tragic (illusionism); sometimes we delegate the tragic choice to others (delegation); sometimes we make the choice ourselves and bear the psychological consequences (responsibilisation). Each of these strategies has its benefits and costs. One potential advantage of autonomous machines is that they enable a reduced cost form of delegation. However, we only gain the advantage of this reduced cost if we accept that some techno-responsibility gaps are virtuous.
Slice Thickness Optimization for the Focused Ion Beam-Scanning Electron Microscopy 3D Tomography of Hierarchical Nanoporous Gold
Authors: Shkurmanov Alexander , Krekeler Tobias , Ritter Martin 
Published: March 2022

AbstractThe combination of focused ion beam (FIB) with scanning electron microscopy (SEM), also known as FIB-SEM tomography, has become a powerful 3D imaging technique at the nanometer scale. This method uses an ion beam to mill away a thin slice of material, which is then block-face imaged using an electron beam. With consecutive slicing along the z-axis and subsequent imaging, a volume of interest can be reconstructed from the images and further analyzed. Hierarchical nanoporous gold (HNPG) exhibits unique structural properties and has a ligament size of 15–110 nm and pore size of 5–20 nm. Accurate reconstruction of its image is crucial in determining its mechanical and other properties. Slice thickness is one of the most critical and uncertain parameters in FIB-SEM tomography. For HNPG, the slice thickness should be at least half as thin as the pore size and, in our approach, should not exceed 10 nm. Variations in slice thickness are caused by various microscope and sample parameters, e.g., converged ion milling beam shape, charging effects, beam drift, or sample surface roughness. Determining and optimizing the actual slice thickness variation appear challenging. In this work, we examine the influence of ion beam scan resolution and the dwell time on the mean and standard deviation of slice thickness. After optimizing the resolution and dwell time to achieve the target slice thickness and lowest possible standard deviation, we apply these parameters to analyze an actual HNPG sample. Our approach can determine the thickness of each slice along the z-axis and estimate the deviation of the milling process along the y-axis (slow imaging axis). For this function, we create a multi-ruler structure integrated with the HNPG sample.
The Three Faces of Populism in Power: Polity, Policies and Politics
Authors: Caiani Manuela , Graziano Paolo 
Published: March 2022

AbstractIn this article, we explore the consequences of the increasing presence of both left- and right-wing populist parties in government, critically reflecting on the recent scholarship on the topic, underlining promising venues for future research and outlining a conceptual framework which constitutes the background of this special issue entitled ‘Populism in Power and its Consequences’. Our main contribution is empirical, since – by reflecting on the various articles hosted in the special issue – we assess the impact of populist parties in government on politics, polities and various policy domains. We also provide an account of potential moderating factors of the influence of populists in government, focus on different ideological underpinnings of types of populisms (left-wing and right-wing) and discuss their relevance. We conclude by identifying four possible scenarios for European populist parties in governments: radicalization, compromise and moderation, splintering, or loss.
Spatial modeling of dyadic geopolitical interactions between moving actors
Authors: Kim Sangyeon , Liu Howard , Desmarais Bruce 
Published: March 2022

AbstractPolitical actors often interact spatially, and move around. However, with a few exceptions, existing political research has analyzed spatial dependence among actors with fixed geographic locations. Focusing on fixated geographic units prevents us from probing dependencies in spatial interaction between spatially dynamic actors, which are common in some areas of political science, such as sub-national conflict studies. In this note, we propose a method to account for spatial dependence in dyadic interactions between moving actors. Our method uses the spatiotemporal histories of dyadic interactions to project locations of future interactions—projected actor locations (PALs). PALs can, in turn, be used to model the likelihood of future dyadic interactions. In a replication and extension of a recent study of subnational conflict, we find that using PALs improves the predictive performance of the model and indicates that there is a clear relationship between actors’ past conflict locations and the likelihood of future conflicts.
Variation of lacustrine carbonate deposition in the Eocene Dongying Depression and its comparison with Holocene environments
Authors: Wu Jing , Liang Chao , Yang Renchao , Xie Jun 
Published: March 2022

AbstractThe sedimentary characteristics and preservation potential of lacustrine carbonates provide fundamental information on climate change. The lacustrine carbonate deposition in the Eocene Dongying Depression was investigated using a combination of mineralogical, petrological and geochemical analyses. Micritic calcite/dolomite, granular calcite, columnar calcite, calcareous shell fragments and reworked detrital calcite were identified. Varying patterns of carbonates (VPC) including lithofacies, geochemical indicators and carbonate distribution were revealed in the Dongying Depression: (i) carbonates hardly precipitate in the nearshore area (average 12 wt %); (ii) carbonate content is high (average 53 wt %) in the shallow lake and (iii) gradually decreases to reach a minimum (average 24 wt %) in the deeper part of the lake. Comparison of VPC in four Holocene lakes (the Qinghai Lake and Barkol Lake in China, Oro Lake in Canada and Montcortès Lake in Spain) with the Dongying Depression suggests that four distinct lake stages were developed, namely the terrigenous clastic/gypsum-rich, carbonate-rich, carbonate-decreasing and carbonate-poor stages. A depositional model of lacustrine carbonates influenced by detrital influx, climate, palaeoproductivity and salinity is developed. This study contributes to the understanding of the genetic mechanisms of lacustrine carbonate deposition to reconstruct environmental changes.
Reflections on the sequence of musical development
Authors: Swanwick Keith 
Published: March 2022

AbstractThe sequence of musical development is revisited. The origins of the underlying and evolving theory are considered, along with organisation and classification of the data of children’s compositions. The cumulative and recursive nature of the spiral is re-emphasised, and the dynamic relationship between the left and right side is clarified. The essential qualitative nature of the study is asserted and some possibilities for the future are considered, along with a two-dimensional model for curriculum and student evaluation based on spiral-related outcomes and the musical activities that promote and sustain them.
Living with the spiral: a duoethnographic perspective
Authors: McCullough Lis , Finney John 
Published: March 2022

AbstractThe authors of this article met on a Master of Arts (MA) music education course a month before the Swanwick Tillman Sequence of Musical Development was published. The course was a portal to an exciting range of literature, with the Swanwick Tillman spiral providing a long-term source of discussion and reflection as our careers have diverged and converged over the intervening years. This paper takes the form of a duoethnographic conversation in which we summarise and reflect on that ongoing synergistic discussion, showing the influence the spiral has had within our particular situations.
Reaching out to early-career astrobiologists: AbGradE's actions and perspectives
Authors: Nauny Philippe , Cassaro Alessia , Kopacz Nina , Noack Lena , Palabikyan Hayk , Pinna Silvana , Price Alex , Stavrakakis Hector A. , Taubner Ruth-Sophie 
Published: March 2022

AbstractAstrobiology Graduates in Europe (AbGradE, pronounced ab-grad-ee) is an association of early-career scientists working in fields relevant to astrobiological research. Conceptualized in 2013, it was initially designed as a mini-conference or workshop dedicated to early-career researchers, providing a friendly environment where early-career minds would be able to present their research without being intimidated by the possibility of facing a more traditional audience, composed mainly of senior scientists. Within the last couple of years, AbGradE became the first point of call for European, but also for an increasing number of non-European, early-career astrobiologists. This article aims to present how AbGradE has evolved over the years (in its structure and in its way of organizing events), how it has adapted with the COVID-19 pandemic, and what future developments are considered.
An Inversion Framework for Optimizing Non‐Methane VOC Emissions Using Remote Sensing and Airborne Observations in Northeast Asia During the KORUS‐AQ Field Campaign
Authors: Choi Jinkyul , Henze Daven K. , Cao Hansen , Nowlan Caroline R. , González Abad Gonzalo , Kwon Hyeong‐Ahn , Lee Hyung‐Min , Oak Yujin J. , Park Rokjin J. , Bates Kelvin H. , Maasakkers Joannes D. , Wisthaler Armin , Weinheimer Andrew J. 
Published: March 2022

AbstractWe aim to reduce uncertainties in CH2O and other volatile organic carbon (VOC) emissions through assimilation of remote sensing data. We first update a three‐dimensional (3D) chemical transport model, GEOS‐Chem with the KORUSv5 anthropogenic emission inventory and inclusion of chemistry for aromatics and C2H4, leading to modest improvements in simulation of CH2O (normalized mean bias (NMB): −0.57 to −0.51) and O3 (NMB: −0.25 to −0.19) compared against DC‐8 aircraft measurements during KORUS‐AQ; the mixing ratio of most VOC species are still underestimated. We next constrain VOC emissions using CH2O observations from two satellites (OMI and OMPS) and the DC‐8 aircraft during KORUS‐AQ. To utilize data from multiple platforms in a consistent manner, we develop a two‐step Hybrid Iterative Finite Difference Mass Balance and four‐dimensional variational inversion system (Hybrid IFDMB‐4DVar). The total VOC emissions throughout the domain increase by 47%. The a posteriori simulation reduces the low biases of simulated CH2O (NMB: −0.51 to −0.15), O3 (NMB: −0.19 to −0.06), and VOCs. Alterations to the VOC speciation from the 4D‐Var inversion include increases of biogenic isoprene emissions in Korea and anthropogenic emissions in Eastern China. We find that the IFDMB method alone is adequate for reducing the low biases of VOCs in general; however, 4D‐Var provides additional refinement of high‐resolution emissions and their speciation. Defining reasonable emission errors and choosing optimal regularization parameters are crucial parts of the inversion system. Our new hybrid inversion framework can be applied for future air quality campaigns, maximizing the value of integrating measurements from current and upcoming geostationary satellite instruments.
Identification of novel rheumatoid arthritis-associated MiRNA-204-5p from plasma exosomes
Authors: Wu Long-Fei , Zhang Qin , Mo Xing-Bo , Lin Jun , Wu Yang-Lin , Lu Xin , He Pei , Wu Jian , Guo Yu-Fan , Wang Ming-Jun , Ren Wen-Yan , Deng Hong-Wen , Lei Shu-Feng , Deng Fei-Yan 
Published: March 2022

AbstractRheumatoid arthritis (RA) is an autoimmune disease characterized by infiltration of immune cells in the synovium. However, the crosstalk of immune cells and synovial fibroblasts is still largely unknown. Here, global miRNA screening in plasma exosomes was carried out with a custom microarray (RA patients vs. healthy controls = 9:9). A total of 14 exosomal miRNAs were abnormally expressed in the RA patients. Then, downregulated expression of exosomal miR-204-5p was confirmed in both the replication (RA patients vs. healthy controls = 30:30) and validation groups (RA patients vs. healthy controls = 56:60). Similar to the findings obtained in humans, a decreased abundance of exosomal miR-204-5p was observed in mice with collagen-induced arthritis (CIA). Furthermore, Spearman correlation analysis indicated that plasma exosomal miR-204-5p expression was inversely correlated with disease parameters of RA patients, such as rheumatoid factor, erythrocyte sedimentation rate, and C-reactive protein. In vitro, our data showed that human T lymphocytes released exosomes containing large amounts of miR-204-5p, which can be transferred into synovial fibroblasts, inhibiting cell proliferation. Overexpression of miR-204-5p in synovial fibroblasts suppressed synovial fibroblast activation by targeting genes related to cell proliferation and invasion. In vivo assays found that administration of lentiviruses expressing miR-204-5p markedly alleviated the disease progression of the mice with CIA. Collectively, this study identified a novel RA-associated plasma exosomal miRNA-204-5p that mediates the communication between immune cells and synovial fibroblasts and can be used as a potential biomarker for RA diagnosis and treatment.
Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction
Authors: Wang Hui , Lv Daoyuan , Jiang Song , Hou Qing , Zhang Lei , Li Shen , Zhu Xiaodong , Xu Xiaodong , Wen Jianqiang , Zeng Caihong , Zhang Mingchao , Yang Fan , Chen Zhaohong , Zheng Chunxia , Li Jing , Zen Ke , Liu Zhihong , Li Limin 
Published: March 2022

AbstractPodocyte damage mediated by in situ complement activation in the glomeruli is a key factor in the pathogenesis of membranous nephropathy (MN), but the molecular mechanism has not been fully elucidated. Pyroptosis is a special type of programmed cell death, mediate inflammatory response and induce tissue injury. However, it is not clear whether pyroptosis is involved in the development and progression of MN. Here, we report that pyroptosis plays an important role in promoting podocyte injury in MN. We first observed the occurrence of pyroptosis in the kidneys of MN patients and validated that complement stimulation triggered pyroptosis in podocytes and that inhibiting pyroptosis reversed complement-induced podocyte damage in vitro. In addition, stimulation of complement caused mitochondrial depolarization and reactive oxygen species (ROS) production in podocytes, and inhibition of ROS reversed complement-induced pyroptosis in podocytes. Interestingly, inhibition of pyroptosis in turn partially alleviated these effects. Furthermore, we also found the involvement of pyroptosis in the kidneys of passive Heymann nephritis (PHN) rats, and inhibitors of pyroptosis-related molecules relieved PHN-induced kidney damage in vivo. Our findings demonstrate that pyroptosis plays a critical role in complement-induced podocyte damage in MN and mitochondrial dysfunction is an important mechanism underlying this process. It provides new insight that pyroptosis may serve as a novel therapeutic target for MN treatment in future studies.
Cumulative lifetime stressor exposure assessed by the STRAIN predicts economic ambiguity aversion
Authors: Raio Candace M. , Lu Benjamin B. , Grubb Michael , Shields Grant S. , Slavich George M. , Glimcher Paul 
Published: March 2022

AbstractUncertainty is inherent in most decisions humans make. Economists distinguish between two types of decision-making under non-certain conditions: those involving risk (i.e., known outcome probabilities) and those that involve ambiguity (i.e., unknown outcome probabilities). Prior research has identified individual differences that explain risk preferences, but little is known about factors associated with ambiguity aversion. Here, we hypothesized that cumulative exposure to major psychosocial stressors over the lifespan might be one factor that predicts individuals’ ambiguity aversion. Across two studies (Study 1: n = 58, Mage = 25.7; Study 2: n = 188, Mage = 39.81), we used a comprehensive lifetime stressor exposure inventory (i.e., the Stress and Adversity Inventory for Adults, or STRAIN) and a standard economic approach to quantify risk and ambiguity preferences. Greater lifetime stressor exposure as measured by the STRAIN, particularly in early life, was associated with higher aversion to ambiguity but not risk preferences.
Pervasive Transcription-coupled DNA repair in E. coli
Authors: Martinez Britney , Bharati Binod K. , Epshtein Vitaly , Nudler Evgeny 
Published: March 2022

AbstractGlobal Genomic Repair (GGR) and Transcription-Coupled Repair (TCR) have been viewed, respectively, as major and minor sub-pathways of the nucleotide excision repair (NER) process that removes bulky lesions from the genome. Here we applied a next generation sequencing assay, CPD-seq, in E. coli to measure the levels of cyclobutane pyrimidine dimer (CPD) lesions before, during, and after UV-induced genotoxic stress, and, therefore, to determine the rate of genomic recovery by NER at a single nucleotide resolution. We find that active transcription is necessary for the repair of not only the template strand (TS), but also the non-template strand (NTS), and that the bulk of TCR is independent of Mfd – a DNA translocase that is thought to be necessary and sufficient for TCR in bacteria. We further show that repair of both TS and NTS is enhanced by increased readthrough past Rho-dependent terminators. We demonstrate that UV-induced genotoxic stress promotes global antitermination so that TCR is more accessible to the antisense, intergenic, and other low transcribed regions. Overall, our data suggest that GGR and TCR are essentially the same process required for complete repair of the bacterial genome.
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines
Authors: Leo Isabelle Rose , Aswad Luay , Stahl Matthias , Kunold Elena , Post Frederik , Erkers Tom , Struyf Nona , Mermelekas Georgios , Joshi Rubin Narayan , Gracia-Villacampa Eva , Östling Päivi , Kallioniemi Olli P. , Tamm Katja Pokrovskaja , Siavelis Ioannis , Lehtiö Janne , Vesterlund Mattias , Jafari Rozbeh 
Published: March 2022

AbstractAcute lymphoblastic leukemia (ALL) is the most common childhood cancer. Although standard-of-care chemotherapeutics are sufficient for most ALL cases, there are subsets of patients with poor response who relapse in disease. The biology underlying differences between subtypes and their response to therapy has only partially been explained by genetic and transcriptomic profiling. Here, we perform comprehensive multi-omic analyses of 49 readily available childhood ALL cell lines, using proteomics, transcriptomics, and pharmacoproteomic characterization. We connect the molecular phenotypes with drug responses to 528 oncology drugs, identifying drug correlations as well as lineage-dependent correlations. We also identify the diacylglycerol-analog bryostatin-1 as a therapeutic candidate in the MEF2D-HNRNPUL1 fusion high-risk subtype, for which this drug activates pro-apoptotic ERK signaling associated with molecular mediators of pre-B cell negative selection. Our data is the foundation for the interactive online Functional Omics Resource of ALL (FORALL) with navigable proteomics, transcriptomics, and drug sensitivity profiles at https://proteomics.se/forall.