bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and drug persistence of baricitinib monotherapy is similar to combination therapy in patients with active RA: a prospective observational study
Authors: Bayat Sara , Tascilar Koray , Bohr Daniela , Krönke Gerhard , Simon David , Knitza Johannes , Hartmann Fabian , Schett Georg , Kleyer Arnd 
Published: November 2022

BackgroundBaricitinib (BARI) is approved for the treatment of rheumatoid arthritis (RA) after failure of conventional synthetic and biologic disease modifying anti-rheumatic drugs (cs/bDMARDs) in combination with methotrexate (MTX) or as monotherapy. However, real-world data are scarce regarding efficacy and drug persistence for BARI monotherapy (BARI-mono) versus its combination with MTX (BARI-combo).ObjectiveTo evaluate efficacy and drug persistence of BARImono compared with BARI-combo in routine clinical practiceMethodsPatients with RA who were switched to BARI were included in a prospective, monocentric cohort. Demographics, clinical outcomes, adverse events and medication were prospectively recorded every 3 months. Clinical efficacy was measured by DAS-28 ESR while drug persistence was measured as the time on drug. We estimated least-square mean DAS-28 scores over time using linear mixed effects models including time-group interactions. Kaplan-Meier method was used to estimate BARI survival and probability of remission over time.Results139 patients (98 women; aged 58.4 (12.8) years; mean disease duration of 9.7 years) were included between 2017 and 2021. 46 patients received BARI-combo, 93 patients received BARI-mono. Mean DAS-28 ESR were not significantly but only numerically different between both groups at baseline and multiple timepoints over follow-up. DAS-28 ESR remission was attained at least once upto 48 weeks in 62% and 51% patients in BARI-combo versus BARI-mono group (log-rank p=0.64). Drug persistence was high (69 vs 67% at 48 weeks and 62% vs 56% at 96 weeks) and similar in BARI-combo-treated and BARI-mono-treated patients. b/ts DMARD naïve patients had lower mean DAS-28 scores over the follow-up and attained DAS-28 ESR remission earlier than patients with inadequate response to b/ts DMARDs (p=0.11). BARI was discontinued in 11/139 patients (7.9%) due to adverse effects.ConclusionIn routine practice, BARI is effective as monotherapy in case of MTX intolerance with overall high drug persistence rates. No new safety signals were observed.
Sources of rare earth elements in the environment and their impact on living organisms
Authors: Sysolyatina M.A. , Olkova A.S. 
Published: November 2022

This review paper aims at understanding natural and anthropogenic sources of rare earth elements (REEs) in the environment, their mechanisms of action, individual toxicity of REEs, and individual toxicity of their mixtures, including with other toxicants. We also summarized the scientific knowledge on REE bioaccumulation by plants, animals, and fungi. The purpose of the work was to analyze published scientific information and identify unsolved scientific issues in the selected areas. At present, both natural positive geochemical anomalies of REEs and “spots” of anthropogenic origin are discovered. There is a relationship between natural and anthropogenic sources of REEs in the environment. Increasing REE mining leads to the exposure of rock layers rich in target elements, which are then leached from natural and waste rocks. As a result, the total content of REEs in soils of their extraction areas reaches 2.3 µg/kg, and in the snow of cities it ranges from 0.411 to 1.463 µg/kg, which is comparable with natural anomalies of elements. Most often such levels of REE accumulation are not dangerous for biota. REEs, like many trace elements, have an essential effect in low concentrations and have harmful effects only when the dose is increased. However, stimulation effects proven for agricultural plants and animals in the natural environment can influence the change in population and community structures. The effects of REE compounds have many uncertainties under the conditions of their joint action with each other and with other substances containing biogenic or potentially toxic elements. The article provides examples of additive, synergistic, and antagonistic actions of a mixture of elements. Further, it is shown that the bioaccumulation of REEs is comparable to the accumulation of heavy metals in living organisms. Data on the transfer of REEs along trophic chains are single and contradictory. Thus, REEs contribute to the toxic load on living organisms. The main “blank spots” in knowledge about the action of REEs that require further research are identification of the most sensitive and vulnerable species, establishment of long-term effects and clarification of the joint action of REEs with other substances.
The Application of Interactive Humanoid Robots in the History Education of Museums Under Artificial Intelligence
Authors: Yang Kuan , Wang Hongkai 
Published: November 2022

The purpose is to improve the application of museum robots in museum scenes, enhance the service capabilities of robots in museums, break tourists’ boring concepts of museum environment, manual explanation, services, etc., and promote tourists’ exhibition experience. A method for sentiment analysis of humanoid robots in museums is proposed by studying the transformation of museums with the help of artificial intelligence (AI) technology, as well as the function and significance of museums in history education. First, the function of museums in history education and the role of AI in constructing intelligent museums are described. Second, on account of the multimodal sentiment analysis method of speech and emotion, a scenario model of the visitor museum is established. An uncertain reasoning method for robot service tasks based on Multi-entity Bayesian network (MEBN) is also proposed. Finally, the proposed model is validated by experiments. The results show that compared with the recognition rates of Arousal and Valence dimensions, the consistency correlation coefficient value of the Kalman filter is higher. The Consistency Correlation Coefficient (CCC) value of the Arousal dimension is 0.703, and the CCC value of the Valence dimension is 0.766. Besides, in different tour times, the proportion of services that tourists want to be provided with varies in different emotional states. From time t1 to time t2, the proportion of tourists who want to hear explanations of cultural relics dropped by 11.5%, while the proportion of tourists who want to be provided with tea service increased by 24%. This indicates that when the Kalman filter algorithm performs continuous emotion recognition of a multimodal fusion, the final emotion recognition accuracy is higher, and emotion analysis can help humanoid robots to be more intelligent and humanized. The proposed sentiment analysis based on the multimodal analysis and MEBN’s uncertainty reasoning method for robot service tasks not only broadens the practical application field of intelligent robots under human–computer interaction technology but also has important research significance for the innovative education development of museum history education.
The provenance of Avalonia and its tectonic implications: a critical reappraisal
Authors: Murphy J. Brendan , Nance R. Damian , Wu Lei 
Published: November 2022

Abstract

The late Neoproterozoic–Cambrian interval is characterized by global-scale orogenesis, rapid continental growth and profound changes in Earth systems. Orogenic activity involved continental collisions spanning more than 100 myr, culminating in Gondwana amalgamation. Avalonia is an example of arc magmatism and accretionary tectonics as subduction zones re-located to Gondwana's periphery in the aftermath of those collisions, and its evolution provides significant constraints for global reconstructions. Comprising late Neoproterozoic (
c.
650–570 Ma) arc-related magmatic and metasedimentary rocks, Avalonia is defined as a composite terrane by its latest Ediacaran–Ordovician overstep sequence: a distinctive, siliciclastic-dominated cover bearing ‘Acado-Baltic’ fauna. This definition implies that Neoproterozoic Avalonia may consist of several terranes, and so precise palaeomagnetic or provenance determination in one locality need not apply to all. On the basis of detrital zircon and Nd isotopic data, Avalonia and other lithotectonically related terranes, such as Cadomia, have long been thought to have resided along the Amazonian–West African margin of Gondwana between
c.
650 and 500 Ma – Avalonia connected to Amazonia, and Cadomia to West Africa. These interpretations have constrained Paleozoic reconstructions, many of which imply that the departure of several peri-Gondwanan terranes led to the Early Paleozoic development of the Rheic Ocean whose subsequent demise in the Late Paleozoic led to Pangaea's amalgamation. Since these ideas were proposed, several new lines of evidence have challenged the Amazonian affinity of Avalonia. First, there is evidence that some Avalonian terranes may have been ‘peri-Baltican’ during the Neoproterozoic. Baltica was originally excluded as a potential source for Avalonia because, unlike Amazonia, arc-related Neoproterozoic rocks were not documented. However, subsequent recognition of Ediacaran arc-related sequences in the Timanides of northeastern Baltica invalidates this assumption. Second, detailed palaeontological and lithostratigraphic studies have been interpreted to reflect an insular Avalonia, well removed from either Gondwana or Baltica during the Ediacaran and early Cambrian. Third, recent palaeomagnetic data have raised the possibility of an ocean (Clymene Ocean) between Amazonia and West Africa in the late Neoproterozoic, thereby challenging conventional reconstructions that show the ‘peri-Gondwanan’ terranes as a contiguous belt straddling the suture zone between these cratons. In this contribution, we critically re-evaluate the provenance of the so-called ‘peri-Gondwanan’ terranes, the contiguity of the so-called ‘Avalonian–Cadomian’ belt and the validity of the various plate tectonic models based on the traditional interpretation of these terranes. In addition, we draw attention to critical uncertainties and the challenges that lie ahead.
Neoadjuvant Chemotherapy in Ovarian Cancer: Are There Racial Disparities in Use and Survival?
Authors: Amin Saber A. , Collin Lindsay J. , Setoguchi Soko , Satagopan Jaya M. , Buckley de Meritens Alexandre , Bandera Elisa V. 
Published: November 2022

AbstractBackground:We investigated racial and ethnic disparities in treatment sequence [i.e., neoadjuvant chemotherapy (NACT) plus interval debulking surgery (IDS) versus primary debulking surgery (PDS) plus adjuvant chemotherapy] among patients with ovarian cancer and its contribution to disparities in mortality.Methods:Study included 37,566 women ages ≥18 years, diagnosed with stage III/IV ovarian cancer from the National Cancer Database (2004–2017). Logistic regression was used to compute ORs and 95% confidence intervals (CI) for racial and ethnic disparities in treatment sequence. Cox proportional hazards regression was used to estimate HRs and 95% CI for racial and ethnic disparities in all-cause mortality.Results:Non-Hispanic Black (NHB) and Asian women were more likely to receive NACT plus IDS relative to PDS plus adjuvant chemotherapy than non-Hispanic White (NHW) women (OR: 1.12; 95% CI: 1.02–1.22 and OR: 1.12; 95% CI: 0.99–1.28, respectively). Compared with NHW women, NHB women had increased hazard of all-cause mortality (HR: 1.14; 95% CI: 1.09–1.20), whereas Asian and Hispanic women had a lower hazard of all-cause mortality (HR: 0.81; 95% CI: 0.74–0.88 and HR: 0.83; 95% CI: 0.77–0.88, respectively), which did not change after accounting for treatment sequence.Conclusions:NHB women were more likely to receive NACT plus IDS and experience a higher all-cause mortality rates than NHW women.Impact:Differences in treatment sequence did not explain racial disparities in all-cause mortality. Further evaluation of racial and ethnic differences in treatment and survival in a cohort of patients with detailed treatment information is warranted.
Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2
Authors: Sun Ling-Yue , Lyu Yu-Yan , Zhang Heng-Yuan , Shen Zhi , Lin Guan-Qiao , Geng Na , Wang Yu-Li , Huang Lin , Feng Ze-Hao , Guo Xiao , Lin Nan , Ding Song , Yuan An-Cai , Zhang Lan , Qian Kun , Pu Jun 
Published: November 2022

Background:
Metabolic disorder increases the risk of abdominal aortic aneurysm (AAA). NRs (nuclear receptors) have been increasingly recognized as important regulators of cell metabolism. However, the role of NRs in AAA development remains largely unknown.

Methods:

We analyzed the expression profile of the NR superfamily in AAA tissues and identified NR1D1 (NR subfamily 1 group D member 1) as the most highly upregulated NR in AAA tissues. To examine the role of NR1D1 in AAA formation, we used vascular smooth muscle cell (VSMC)–specific, endothelial cell–specific, and myeloid cell–specific conditional
Nr1d1
knockout mice in both AngII (angiotensin II)– and CaPO
4
-induced AAA models.

Results:

Nr1d1
gene expression exhibited the highest fold change among all 49 NRs in AAA tissues, and NR1D1 protein was upregulated in both human and murine VSMCs from AAA tissues. The knockout of
Nr1d1
in VSMCs but not endothelial cells and myeloid cells inhibited AAA formation in both AngII- and CaPO
4
-induced AAA models. Mechanistic studies identified ACO2 (aconitase-2), a key enzyme of the mitochondrial tricarboxylic acid cycle, as a direct target trans-repressed by NR1D1 that mediated the regulatory effects of NR1D1 on mitochondrial metabolism. NR1D1 deficiency restored the ACO2 dysregulation and mitochondrial dysfunction at the early stage of AngII infusion before AAA formation. Supplementation with αKG (α-ketoglutarate, a downstream metabolite of ACO2) was beneficial in preventing and treating AAA in mice in a manner that required NR1D1 in VSMCs.

Conclusions:
Our data define a previously unrecognized role of nuclear receptor NR1D1 in AAA pathogenesis and an undescribed NR1D1-ACO2 axis involved in regulating mitochondrial metabolism in VSMCs. It is important that our findings suggest αKG supplementation as an effective therapeutic approach for AAA treatment.
Difference and Novelty: An Exploration of the Taiwan Studies Programme at the University of Nottingham
Authors: Lee Chun-Yi , Wysoczanska Karolina 
Published: November 2022

Abstract
This report introduces the Taiwan Studies Programme (tsp) at the University of Nottingham and its development in different stages and fields. It also delineates the tsp’s pathways to connect with the academic circle and the general public. Through its online magazine and platform, Taiwan Insight, it has established an online community that has been growing since 2017. The Covid-19 pandemic has helped further expanded tsp’s reach and engagement with its audience through online seminars and workshops. The last part of the report indicates future tasks for the tsp.
A Radio Drama’s Effects on Attitudes Toward Early and Forced Marriage: Results From a Field Experiment in Rural Tanzania
Authors: Green Donald P. , Groves Dylan W. , Manda Constantine , Montano Beatrice , Rahmani Bardia 
Published: November 2022

Early and forced marriage (EFM) is an increasing focus of international organizations and local non-government organizations. This study assesses the extent to which attitudes and norms related to EFM can be changed by locally tailored media campaigns. A two-hour radio drama set in rural Tanzania was presented to Tanzanian villagers as part of a placebo-controlled experiment randomized at the village level. A random sample of 1200 villagers was interviewed at baseline and invited to a presentation of the radio drama, 83% of whom attended. 95% of baseline respondents were re-interviewed two weeks later, and 97% 15 months after that. The radio drama produced sizable and statistically significant effects on attitudes and perceived norms concerning forced marriage, which was the focus of the radio drama, as well as more general attitudes about gender equality. Fifteen months later, treatment effects diminished, but we continue to see evidence of EFM-related attitude change.
The Lived Experiences of Top Women Contributors to Leading Economic Education Journals
Authors: Ferrara Zachary , Asarta Carlos J. 
Published: November 2022

Despite the substantial literature on women in economics, very little qualitative work has been devoted to exploring women’s lived experiences, and even less so on their presence in the economic education subfield. Through interviewing top female contributors to the three leading economic education journals, new insights regarding their experiences within the profession are presented, including challenges they have faced and addressed, the roles colleagues and institutions play in their scholarship, and how research itself fits into their overall careers. JEL Codes: A11, A20, I23
Otitis media and interna with or without polyps in cats: association between meningeal enhancement on postcontrast MRI, cerebrospinal fluid abnormalities, and clinician treatment choice and outcome
Authors: Dutil Guillaume F , Guevar Julien , Schweizer Daniela , Roosje Petra , Kajin Filip , Volk Holger A , Grapes Nick J , De Decker Steven , Gutierrez-Quintana Rodrigo , Abouzeid Jad , Freeman Paul , Faller Kiterie ME , Stein Veronika M , Maiolini Arianna 
Published: November 2022

Objectives The aim of this study was to evaluate the association between meningeal enhancement (MgE) and cerebrospinal fluid (CSF) analysis results, their individual association with bacteriology results from affected ear samples and whether these test results influenced clinicians’ therapeutic choice in cats with otitis media and interna (OMI). Methods This was a multicentre retrospective study carried out over an 8-year period. Cats diagnosed with OMI, with or without a nasopharyngeal polyp, leading to peripheral vestibular signs were included. Only cats for which MRI with postcontrast T1-weighted sequences and CSF analyses available were included. Cats with intra-axial MRI lesions or empyema were excluded. Results Fifty-eight cats met the inclusion criteria. MgE was reported in 26/58 cases, of which nine had an abnormal CSF result (increased total nucleated cell count [TNCC] or total protein); 32/58 cases had no MgE, of which 10 showed abnormal CSF results. There was no association between bacteriology results (external ear canal or bulla) and MgE or abnormal CSF results. CSF abnormalities were statistically significantly more common in acute cases (n = 16/37) than in chronic cases (n = 3/21; Fischer’s test P = 0.04). Prednisolone was prescribed in 10/16 cases with increased TNCC. Among the 42 cases with normal TNCC, 15 received prednisolone and 13 received non-steroidal anti-inflammatory drugs. Various antimicrobial drugs were prescribed in 53/58 cats. Duration of antimicrobial treatment was similar, regardless of positive bacterial culture (5.58 vs 4.22 weeks), abnormal CSF (5.83 vs 4.76 weeks) or MgE (5.33 vs 4.90 weeks). Conclusions and relevance No association was found between the CSF and MgE results. Furthermore, no association was found between MgE, CSF or bacteriology findings. In addition, abnormal CSF results might lead the clinician to treat with corticosteroids, but they did not have any impact on duration of antimicrobial treatment. CSF abnormalities were seen significantly less frequently in chronic cases. The outcome tended to be poorer when MgE was detected on MRI.
Cardiopulmonary and propofol-sparing effects of dexmedetomidine in total intravenous anesthesia in cats undergoing ovariohysterectomy
Authors: Sanches Mariana C , Bessi Wellington H , Rusch Elidiane , Schaffhausser Marianna B , Cassoli Ana A , Freitas Silvio H , Gehrcke Martielo I , Carregaro Adriano B 
Published: November 2022

Objectives This study aimed to assess the effect of dexmedetomidine on the propofol-based anesthesia of cats subjected to ovariohysterectomy. Methods Twenty-eight cats were randomly allocated to four groups (seven cats in each) and premedicated with either 5 µg/kg dexmedetomidine (groups Dex 1, Dex 3 and Dex 5) or 0.05 ml saline (Prop group) intramuscularly. After the induction of anesthesia with propofol, total intravenous anesthesia was initiated with 300 µg/kg/min propofol plus 3 ml/kg/h NaCl 0.9% (Prop), or 200 µg/kg/min propofol plus dexmedetomidine at the rates of 1 µg/kg/h (Dex 1), 3 µg/kg/h (Dex 3) or 5 µg/kg/h (Dex 5). Cardiorespiratory variables were assessed 5 mins after induction and every 10 mins thereafter, until the end of anesthesia. The propofol infusion rate was adjusted every 10 mins (± 50 µg/kg/min) to maintain anesthetic depth. The times to extubation, sternal recumbency, ambulation and total recovery were recorded. Pain scoring was performed 1, 2, 4, 8, 12 and 24 h after the end of anesthesia. Results Dexmedetomidine produced a propofol-sparing effect of 72.8%, 71.1% and 74.6% in the Dex 1, Dex 3 and Dex 5 groups, respectively. Cats in the Prop group maintained higher heart rate values than the other groups, and the mean arterial pressure remained higher in the Dex 3 and Dex 5 groups. Rescue intraoperative analgesia (fentanyl bolus) was most frequent in the Prop group. There was no significant difference in the time of extubation. Cats in the Dex 1 and Dex 3 groups had a faster anesthetic recovery, with shorter times to achieving sternal recumbency, regaining ambulation and reaching full recovery. Cats in the Dex 1 and Dex 5 groups presented the best recovery quality scores, with 4 (range 4–5) and 4 (range 3–5), respectively, while the Prop group scored 1 (range 1–3), the worst anesthetic recovery score among the groups. Conclusions and relevance The use of dexmedetomidine as a total intravenous anesthesia adjuvant, especially at doses of 1 and 3 µg/kg/h, reduces propofol consumption and improves cardiorespiratory stability and intraoperative analgesia, while promoting a better and quicker recovery from anesthesia.
C1q/TNF-related protein-2 improved angiogenesis to protect myocardial function during ischaemia‒reperfusion
Authors: Ye Mingfang , Wu Qi-Hong , Yang Ke , Luo Yukun 
Published: November 2022

Background Collateral growth plays an important role in the recovery of acute myocardial infarction. C1q/TNF-related protein-2 (CTRP2), a CTRP family member, showed some protective effects on cell survival. In this study, the relationship between CTRP2 and collateral growth was examined. Methods C57BL/6 mice were subjected to myocardial ischaemia/reperfusion (I/R), and the expression of CTRP2 and the effect of CTRP2 on infarction size, cardiac function and angiogenesis were examined. The ischaemic hindlimb model was also used to examine the effect of CTRP2. In vitro, CTRP2-mediated regulation of angiogenesis, AKT activation and VEGFR2 expression in endothelial cells was examined. The CTRP2 level associated with good collateral growth was observed in a cohort. Results I/R reduced CTRP2 expression, and intraperitoneal injection of recombinant CTRP2 protein improved infarction size, cardiac function and angiogenesis. Overexpression of CTRP2 promoted blood refusion and collateral growth in ischaemic hindlimb mice. In vitro, CTRP2 enhanced tube formation and migration in a dose-dependent manner, while CTRP2 increased AKT phosphorylation and VEGFR2 expression. In an observational clinical cohort, CTRP2 levels were significantly increased in patients with good collateral growth, and CTRP2 was negatively associated with poor collateral growth in patients. Conclusion CTRP2 improved cardiac function by promoting collateral growth by promoting AKT-VEGFR2.