bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between Type D personality with atherosclerotic plaque and cardiovascular events: The mediation effect of inflammation and kynurenine/tryptophan metabolism
Authors: Wang Yini , Liu Guojie , Zhao Zhenjuan , Li Ling , Yin Shi , Sun Xiao , Yu Bo , Gao Xueqin , Lin Ping , Yang Yanjie 
Published: October 2022

PurposeCardiovascular events and coronary plaque vulnerability are linked to Type D personality. However, the fundamental mechanism has not been clarified. Our study determined to illustrate whether inflammatory status in plasma, in combination with kynurenine pathway activity in Type D individuals, is associated with plaque vulnerability and cardiovascular events in patients with coronary artery disease (CAD).Materials and methodsThe Type D personality of 177 CAD patients were evaluated. Plasma biomarkers of inflammation (TNF-α, IL-6, and hs-CRP) were measured and pooled into standardized sumscores. Tryptophan and kynurenine metabolites were measured, and the kynurenine/tryptophan ratio (KTR) was calculated. Plaque vulnerability was measured in vivo by optical coherence tomography. All patients had a follow up of 2 years in which cardiovascular adverse events were recorded.ResultsType D individuals exhibited elevated TNF-α (p = 0.007), IL-6 (p = 0.049), inflammation sumscores (p = 0.002), kynurenine (p = 0.008), and KTR (p = 0.005) than non-Type D group. The serial-multiple mediation showed that the Type D personality with a direct, favorable impact on plaque vulnerability, including thin cap fibroatheroma (TCFA) (point estimate = 0.81; 95% CI = 0.09–1.53), macrophages (point estimate = 0.79; 95% CI = 0.05–1.51), and major adverse cardiac events (MACE) (point estimate = 0.88, 95% CI = 0.08–1.70). In addition, the standardized inflammation sumscores and KTR were mediators of the Type D personality associations with TCFA, macrophages and MACE.ConclusionThese results demonstrated that the connection between Type D personality and poor cardiovascular outcomes in CAD patients can be mediated by pro-inflammatory biomarkers and KTR.
Treatment of type 2 diabetes mellitus using the traditional Chinese medicine Jinlida as an add-on medication: A systematic review and meta-analysis of randomized controlled trials
Authors: Zhao Xuemin , Liu Linfei , Liu Jing 
Published: October 2022

BackgroundNumerous randomized controlled trials (RCTs) conducted in China have shown that jinlida granules are a promising traditional Chinese medicine (TCM) for the treatment of persons with type 2 diabetes mellitus (T2DM). Controversial results have been reported in different RCTs. The aim of our study was to evaluate the adjuvant hypoglycemic effect of jinlida granules on persons with T2DM and to explore the source of heterogeneity between these RCTs.Materials and methodsMedical article databases were individually searched by two authors for RCTs that provided data regarding the effect of jinlida granules in the treatment of T2DM before 1 June 2022. The methodological quality of the included RCTs was comprehensively assessed by two authors. Data from RCTs with low risk of bias were pooled using Stata SE 12.0 (random-effects model). Evidence derived from the meta-analysis will be assessed according to the GRADE system.ResultsTwenty-two RCTs were eventually included in the systematic review and three RCTs with low risk of bias were analyzed in the meta-analysis. Compared with the control groups, significant changes were found in lowering glycosylated hemoglobin a1c (mean difference -0.283 with 95% CI -0.561, -0.004; P=0.046), and were not found in lowering 2-hour postprandial glucose (mean difference -0.314 with 95% CI -1.599, 0.972; P=0.632) and fasting blood glucose (mean difference -0.152 with 95% CI -0.778, -0.474; P=0.634) in the jinlida groups. The GRADE-assessed evidence quality for the outcomes was moderate.ConclusionThe adjuvant hypoglycemic effect of jinlida granules on adult Chinese persons with T2DM was statistically found in lowering HbA1c and was not statistically found in lowering FPG and 2h-PG. Evidence grading should be considered moderate, and the results should be interpreted cautiously. Whether the efficacy of HbA1c-lowering related to clinical significance remains to be investigated in future RCTs. Differences in HbA1c, FPG and 2h-PG at baseline and high risk of bias were important source of heterogeneity between these RCTs. In order to objectively evaluate the efficacy of jinlida granules on T2DM, it is urgently needed that high-quality RCTs evaluating the hypoglycemic effect of jinlida granules in the treatment of qi-yin deficiency pattern T2DM.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42018085135.
Preliminary experience with the EleVision IR system in detection of parathyroid glands autofluorescence and perfusion assessment with ICG
Authors: Makovac Petra , Muradbegovic Mirza , Mathieson Timothy , Demarchi Marco S. , Triponez Frédéric 
Published: October 2022

BackgroundPostoperative hypoparathyroidism remains the most frequent complication of neck endocrine surgery. In order to reduce the incidence of this feared complication, several systems for imaging of near infrared autofluorescence (NIRAF) have been invented to help surgeons identify parathyroid glands (PTGs) and evaluate their vascularization. We evaluated the efficacy of the EleVision IR system in thyroid and parathyroid surgery.MethodsWe used the EleVision IR system in 25 patients who underwent thyroid/parathyroid surgery or both at our institution between December 2020 and July 2021. At various stages of the surgery, the surgeon first looked for PTGs with the naked eye and then completed the visual inspection with NIRAF imaging. We then compared both the naked eye and NIRAF-supported PTGs detection rates. At the end of surgery, we performed indocyanine green angiography of PTGs in 17 patients.ResultsIn total, we identified 80% of PTGs: 65% with the naked eye only and additional 15% with the assistance of the EleVision IR system. 14 of 17 patients evaluated by ICG angiography had at least one well-vascularized PTG. Only one of these patients (a case of subtotal parathyroidectomy for tertiary hyperparathyroidism) developed symptomatic postoperative hypocalcemia despite a normal parathormone level. The three other patients had at least one remaining moderately-vascularized PTG and only one patient developed transient postoperative hypoparathyroidism.ConclusionWe concluded that EleVision IR provides an efficient support for identification and evaluation of PTGs, and may be of great assistance in endocrine surgery. The images are easy to interpret even for less experienced surgeons thanks to the different types of color visualization and the possibility to measure the relative fluorescence intensity of PTGs and surrounding tissues.
Carbonate mineral controls the transport of Cd from tailings to surrounding soils: An example from Cd-rich Niujiaotang Zn mine in Guizhou Province, Southwest China
Authors: Guo Zidong , Gu Shangyi , Li Qingguang , Zhang Tianyi , Xie Xiaofeng , Zhao Fengqi 
Published: October 2022

Heavy metal pollution derived from the oxidation of sulfides in Pb-Zn mine tailings has been a common public concern. Although the oxidative dissolution of sphalerite will release cadmium into the soil environment, it is still unclear whether other minerals contain a large amount of cadmium and how much these minerals contribute to the surrounding environmental media. In this paper, XRD, particle size analyzer, SEM-EDS and improved BCR sequential extraction method were used to analyze cadmium rich zinc mine tailing and adjacent farmland soil in Duyun, Guizhou Province. The results show that the average contents of Pb, Zn, and Cd in tailing are 214 ± 71 mg/kg, 2668 ± 773 mg/kg, and 37.5 ± 9.97 mg/kg respectively. While in the surrounding soil, they were 519 ± 280 mg/kg, 3,779 ± 2614 mg/kg, and 30.8 ± 14.4 mg/kg respectively. The mineralogical composition of tailing is mainly dolomite and less pyrite. Cadmium in tailing is mainly in weak acid extractable state, indicating that cadmium mainly exists in dolomite of tailing. Pyrite in tailing generates acid through oxidation, which accelerates the dissolution of dolomite, thus releasing Cd from minerals and migrating to surrounding farmland, resulting in soil cadmium pollution. This study reveals an important process that has been neglected. Carbonate minerals play an important role in the migration of cadmium in the tailing of the Mississippi Valley-type (MVT) lead-zinc mine and the soils affected by the tailing.
Diagnostic value of RDW for the prediction of mortality in adult sepsis patients: A systematic review and meta-analysis
Authors: Wu Hongsheng , Liao Biling , Cao Tiansheng , Ji Tengfei , Huang Jianbin , Ma Keqiang 
Published: October 2022

BackgroundRed blood cell distribution width (RDW) is a common biomarker of bacterial infections, and it can be easily obtained from a routine blood test. We investigate the diagnostic value of RDW for the prediction of mortality in adult sepsis patients through a review and meta-analysis. We registered this review in PROSPERO (Registration Number: CRD42022357712), and the details of the registration are included in Appendix 1.MethodsWe searched PubMed, Cochrane Library, Springer, and Embase between Jan. 1, 2000, and May 30, 2022, for primary studies about this research. We collected articles that investigated RDW for varying degrees of sepsis patients—those who suffered from sepsis, severe sepsis, or sepsis shock. Studies of healthy people and sepsis of children and neonates were excluded from our research. The definition of study characteristics and data extraction were finished by two independent researchers and discrepancies resolved by consensus. The combined sensitivities and specificities were calculated by meta-analysis using STATA14.0. The sensitivity of the included studies was analyzed by excluding studies that had potential heterogeneity. A summary operating characteristic curve was made to evaluate the diagnostic value for the prediction of mortality in adult sepsis patients. The Fagan test was used to explore likelihood ratios and posttest probabilities. Finally, we investigated the source of heterogeneity using meta-regression.ResultsTwenty-four studies, including 40,763 cases altogether, were included in this analysis. Bivariate analysis indicated a combined sensitivity of 0.81 (95% CI 0.73–0.86) and specificity of 0.65 (95% CI 0.54–0.75). The area under the summary receiver operating characteristic curve was 0.81 (95% CI 0.77–0.84). Substantial heterogeneity resided in the studies (I2 =96.68, 95% CI 95.95–97.4). Meta-regression showed that the reference description, prospective design, and blinded interpretation of the included studies could be responsible for the heterogeneity.ConclusionsRWD is an available and valuable biomarker for prediction of mortality in adult sepsis patients.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022357712.
Machine learning for rock mechanics problems; an insight
Authors: Yu Hao , Taleghani Arash Dahi , Al Balushi Faras , Wang Hao 
Published: October 2022

Due to inherent heterogeneity of geomaterials, rock mechanics involved with extensive lab experiments and empirical correlations that often lack enough accuracy needed for many engineering problems. Machine learning has several characters that makes it an attractive choice to reduce number of required experiments or develop more effective correlations. The timeliness of this effort is supported by several recent technological advances. Machine learning, data analytics, and data management have expanded rapidly in many commercial sectors, providing an array of resources that can be leveraged for subsurface applications. In the last 15 years, deep learning in the form of deep neural networks, has been used very effectively in diverse applications, such as computer vision, seismic inversion, and natural language processing. Despite the remarkable success in these and related areas, deep learning has not yet been widely used in the field of scientific computing specially when it comes to subsurface applications due to the lack of large amount of data to train algorithms. In this paper, we review such efforts and try to envision future game-changing advances that may impact this field.
Impact of dialysis modality choice on the survival of end-stage renal disease patients with congestive heart failure in southern China: A retrospective cohort study
Authors: He Zhiren , Liang Hui , Huang Jing , Zhang Defei , Ma Hongyan , Lin Junjie , Cai Youqing , Liu Tonghuan , Li Hucai , Qiu Weizhong , Wang Lingzheng , Yuan Fengling , Hou Haijing , Zhao Daixin , Liu Xusheng , Wang Lixin 
Published: October 2022

Background and objectHeart failure is one of the common complications in patients with end-stage renal disease (ESRD) and a major cause of death in these patients. The choice of dialysis modality for ESRD patients with congestive heart failure (CHF) is still inconclusive. The purpose of this study was to compare the prognosis of hemodialysis (HD) and peritoneal dialysis (PD) among ESRD patients with CHF and provide a basis for clinical decision-making.Materials and methodsThis was a retrospective study conducted at Guangdong Provincial Hospital of Traditional Chinese Medicine that included patients with CHF requiring long-term renal replacement therapy between January 1, 2012 and December 31, 2017. The end of follow-up was December 31, 2020. All patients were divided into HD and PD groups and sub grouped by age, and we used univariate and multifactorial Cox regression analyses to calculate the relative hazard ratios (HR) of the different dialysis types and adjusted for differences in baseline data using propensity score matching (PSM).ResultA total of 121 patients with PD and 156 patients with HD were included in this study. Among younger ESRD patients (≤65 years of age) with CHF, the prognosis of HD was worse than that of PD [HR = 1.84, 95% confidence interval (CI) = 1.01–3.34], and this disadvantage remained significant in the fully adjusted model [sex, age at dialysis initiation, Charlson comorbidities index, body mass index, prealbumin, hemoglobin, and left ventricular ejection fraction (LVEF)] and after PSM. In the older group (&gt;65 years of age), the prognosis of HD was better than that of PD (HR = 0.46, 95% CI = 0.25–0.85), and the protective effect remained in the fully adjusted model and after PSM. The aforementioned survival differences across the cohort were maintained in patients with preserved LVEF (&gt;55%), but could not be reproduced in patients with reduced LVEF (≤55%).ConclusionIn southern China, PD is a better choice for younger patients with ESRD, CHF and preserved LVEF, and HD is the better option for older patients.
The impact of smoking status on radiographic progression in patients with ankylosing spondylitis on anti-tumor necrosis factor treatment
Authors: Nam Bora , Koo Bon San , Choi Nayeon , Shin Ji-Hui , Lee Seunghun , Joo Kyung Bin , Kim Tae-Hwan 
Published: October 2022

BackgroundAnkylosing spondylitis (AS) is characterized by back pain which can lead to spinal ankylosis. Anti-tumor necrosis factor (TNF) dramatically alleviates symptoms, but spinal damage can still be progressive even during anti-TNF treatment. Smoking is a one of well-known risk factors for structural damage in AS. However, it has not been confirmed that smoking can affect radiographic progression even during anti-TNF treatment.ObjectiveTo investigate factors associated with radiographic progression during anti-TNF treatment with a focus on smoking status which is known as one of poor prognostic factors for AS.Materials and methodsWe conducted a retrospective cohort study of AS patients who began the first-line anti-TNF treatment between 2001 and 2018 according to availability of smoking data. All enrolled patients were observed until the last visit, the first-line anti-TNF discontinuation, or December 2019. Radiographic damage was assessed using the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS). The mSASSS progression rate (units/year) was calculated using the baseline mSASSS, the final mSASSS during observation period, and the duration between them. Univariable and multivariable logistic regression analyses were performed to identify associated factors of mSASSS progression rate &gt; 1 unit/year.ResultsAmong 459 AS patients, 185 (40.3%) patients were never smokers, 62 (13.5%) were ex-smokers and 212 (46.2%) were current smokers at baseline. Ex- and current smokers had higher mSASSS progression rates than never smokers [never smoker 0.1 (0.0–0.7), ex-smoker 0.6 (0.0–1.5), and current smoker 0.6 (0.0–1.5) units/year, P &lt; 0.001]. In the multivariable logistic analysis, current smoking [adjusted odds ratio (OR) 1.69, 95% CI 1.01–2.82, P = 0.047] and higher baseline mSASSS [adjusted OR 1.03, 95% CI 1.01–1.04, P &lt; 0.001] were associated with a mSASSS progression rate &gt; 1 unit/year.ConclusionCurrent smoking is a modifiable risk factor for radiographic progression in patients with AS on anti-TNF treatment. Quitting smoking should be strongly recommended.
A comparative study on biopharmaceutical function of curcumin and miR-34a by multistimuli-responsive nanoniosome carrier: In-vitro and in-vivo
Authors: Abtahi Najmeh Alsadat , Naghib Seyed Morteza , Haghiralsadat Fateme , Akbari Edgahi Mohammadmahdi , Askari Esfandyar 
Published: October 2022

This research conducted a comparative study on nanoscaled niosomal structures consisting of Tween-80, Tween-60, cholesterol, and dioleoyl-3-trimethylammonium propane (DOTAP). Thin-film hydration technique was used for the preparation and entrapment of curcumin and miRNA in niosomal formulations for enhancing the stability and delivery rate of the agents. Herein, the influence of Tween-80, Tween-60, cholesterol, and DOTAP on the entrapment efficiency (EE%) of curcumin and the physicochemical properties of the carrier are fully discussed. The optimum engineered formulation resulted in a positive charge of +11.23 mV, high EE (100%), smooth surface, spherical shape, small diameter (90 nm), and good stability in physiological buffers. Also, an accelerated cellular uptake, as well as drug release in PBS (pH 7.4, 37°C) after 72 h, were observed. The cytotoxic activity of curcumin (Cur)/miR-34a-loaded nanoparticles was determined by the MTT assay. The results displayed an improved cytotoxic activity of Cur-niosome towards cancer cells compared to free-dispersed Cur. The uptake of Cur-loaded niosome by A280s and A280cp-1 cancer cell lines faced 2.5 folds drop in the concentration compared to its free form. Generally, Cur-niosome exhibits a significant accumulation of superior anti-cancer properties. Likewise, the cytotoxicity of miR-34a-niosome against tumor cells was higher in comparison with its free form. The anti-cancer effects of the gene/drug delivery were investigated in the 4T1 xenografted Balb/C mouse tumor model. According to the in vitro and in vivo results, gene delivery from the modified niosome nanoparticles was distinctly greater than Cur delivery. Therefore, it was concluded that encapsulation of genes in the nano-niosomal delivery system is a promising procedure for the treatment of cancer cells.
The effect of regional white matter hyperintensities on essential tremor subtypes and severity
Authors: He Runcheng , Qin Yan , Zhou Xun , Liu Zhenhua , Xu Qian , Guo Jifeng , Yan Xinxiang , Tang Beisha , Zeng Sheng , Sun Qiying 
Published: October 2022

ObjectivesTo investigate the effect of regional white matter hyperintensities (WMHs) on Essential tremor (ET) subtypes and to explore the association between WMHs load and the severity of motor and non-motor symptoms in patients with ET.MethodsA cohort of 176 patients with ET (including 86 patients with pure ET and 90 patients with ET plus) and 91 normal controls (NC) was consecutively recruited. Demographic, clinical, and imaging characteristics were compared between individuals with pure ET, ET plus, and NC. The cross-sectional association among regional WMHs and the severity of tremor and non-motor symptoms were assessed within each group.ResultsCompared with the pure ET subgroup, the ET plus subgroup demonstrated higher TETRAS scores, NMSS scores, and lower MMSE scores (all P &lt; 0.05). Periventricular and lobar WMHs' loads of pure ET subgroup intermediated between NC subjects and ET plus subgroup. WMHs in the frontal horn independently increased the odds of ET (OR = 1.784, P &lt; 0.001). The age (P = 0.021), WMHs in the frontal lobe (P = 0.014), and WMHs in the occipital lobe (P = 0.020) showed a significant impact on TETRAS part II scores in the ET plus subgroup. However, only the disease duration was positively associated with TETRAS part II scores in patients with pure ET (P = 0.028). In terms of non-motor symptoms, NMSS scores of total patients with ET were associated with disease duration (P = 0.029), TETRAS part I scores (P = 0.017), and WMH scores in the frontal lobe (P = 0.033). MMSE scores were associated with age (P = 0.027), body mass index (P = 0.006), education level (P &lt; 0.001), and WMHs in the body of the lateral ventricle (P = 0.005).ConclusionOur results indicated that the WMHs in the frontal horn could lead to an increased risk of developing ET. WMHs may be used to differentiate pure ET and ET plus. Furthermore, WMHs in the frontal and occipital lobes are strong predictors of worse tremor severity in the ET plus subgroup. Regional WMHs are associated with cognitive impairment in patients with ET.
Bayesian neural networks using magnetic tunnel junction-based probabilistic in-memory computing
Authors: Liu Samuel , Xiao T. Patrick , Kwon Jaesuk , Debusschere Bert J. , Agarwal Sapan , Incorvia Jean Anne C. , Bennett Christopher H. 
Published: October 2022

Bayesian neural networks (BNNs) combine the generalizability of deep neural networks (DNNs) with a rigorous quantification of predictive uncertainty, which mitigates overfitting and makes them valuable for high-reliability or safety-critical applications. However, the probabilistic nature of BNNs makes them more computationally intensive on digital hardware and so far, less directly amenable to acceleration by analog in-memory computing as compared to DNNs. This work exploits a novel spintronic bit cell that efficiently and compactly implements Gaussian-distributed BNN values. Specifically, the bit cell combines a tunable stochastic magnetic tunnel junction (MTJ) encoding the trained standard deviation and a multi-bit domain-wall MTJ device independently encoding the trained mean. The two devices can be integrated within the same array, enabling highly efficient, fully analog, probabilistic matrix-vector multiplications. We use micromagnetics simulations as the basis of a system-level model of the spintronic BNN accelerator, demonstrating that our design yields accurate, well-calibrated uncertainty estimates for both classification and regression problems and matches software BNN performance. This result paves the way to spintronic in-memory computing systems implementing trusted neural networks at a modest energy budget.