bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative Threshold of Energy Fractal Dimension for Immediate Rock Burst Warning in Deep Tunnel: A Case Study
Authors: Yu Yang , Feng Guang-liang , Xu Chang-jie , Chen Bing-rui , Geng Da-xin , Zhu Bi-tang 
Published: February 2022

Abstract
Rock bursts are a serious geological disaster occurring in deep underground engineering operations, which will cause casualties and economic loss. The quantitative threshold of energy fractal dimension for immediate rock burst warning in a deep tunnel was studied. The study was conducted based on the immediate rock burst cases in the deep tunnels of Jinping Hydropower Station, China. Firstly, a fractal dimension calculation method was proposed for deep linear tunnels associated with microseismic monitoring to explore the energy fractal dimension during the 37 immediate rock bursts and their development to events of different intensities (intense and moderate events). On this basis, a mechanism analysis was undertaken to assess the distribution range and evolution of the energy fractal dimension in the development of the immediate rock bursts. Then, the energy fractal dimension, as a quantitative threshold, was taken as a criterion for judging the rock burst risk. Furthermore, the corresponding warning index and dynamic control method were established. This index and method were applied in the subsequent construction process. The results can be used as a guide to establish a dynamic warning system based on the microseismicity monitored and provide a scientific basis for the prediction, warning, and risk-control standard of rock burst disasters during excavation of deep tunnels.
Prognostic Value of Textural Features Obtained from F-fluorodeoxyglucose (F-18 FDG) Positron Emission Tomography/Computed Tomography (PET/CT) in Patients with Locally Advanced Cervical Cancer Undergoing Concurrent Chemoradiotherapy
Authors: Cho Hyun-Woong , Lee Eun Seong , Lee Jae Kwan , Eo Jae Seon , Kim Sungeun , Hong Jin Hwa 
Published: February 2022

Abstract
Background
To evaluate whether textural features obtained from F-18 FDG PET/CT offer clinical value that can predict the outcome of patients with locally advanced cervical cancer (LACC) receiving concurrent chemoradiotherapy (CCRT).
Methods
We reviewed the records of 68 patients with stage IIB–IVA LACC who underwent PET/CT before CCRT. Conventional metabolic parameters, shape indices, and textural features of the primary tumor were measured on PET/CT. A Cox regression model was used to examine the effects of variables on overall survival (OS) and progression-free survival (PFS).
Results
PET/CT parameters were grouped into tertiles (low, middle, and high). In the high group, metabolic tumor volume [hazard ratio (HR), 18.94; 95% confidence interval (CI), 2.27–145.01], shape volume (HR, 21.77; 95% CI, 2.85–166.17), shape compacity (HR, 10.53; 95% CI, 2.38–46.54), gray-level non-uniformity (GLNU) from grey-level run length matrix (GLRLM) (HR, 23.80; 95% CI, 3.13–181.31), and run-length non-uniformity from GLRLM (HR, 10.07; 95% CI, 2.28–44.48) were significant factors for poorer PFS. High coarseness from neighborhood grey-level different matrix (NGLDM) was associated with reduction of recurrence (HR, 0.09; 95% CI, 0.02–0.42).
Conclusion
Our results demonstrated that several features including textural indices on pretreatment PET/CT were strong prognostic factors for recurrence in patients with LACC receiving CCRT.
CircOAS3 regulates proliferation and psoriatic inflammation by interacting with Hsc70 via JNK/STAT3/NF-κB signaling pathways in keratinocytes
Authors: Yang Zhenxian , Yin Xiran , Chen Cheng , Huang Shan , Li Xueqing , Yan Jianjun , Sun Qing 
Published: February 2022

Abstract
Psoriasis is a chronic inflammatory disease of the skin with highly complex pathogenesis. CircRNAs play an important regulatory role in plenty of diseases as well as psoriasis. In this study, we identified that circOAS3 was significantly upregulated in both psoriatic tissues and M5-induced keratinocytes. Silencing circOAS3 in HaCaT and Ker-CT cells inhibited cell viability, promoted apoptosis, and blocked the cell cycle from G1 to S phase. RNA-pulldown and RNA immunoprecipitation (RIP) analysis identified the direct combination between circOAS3 and Heat shock cognate protein 70 (Hsc70). Silencing circOAS3 negatively influences the Hsc70 in protein level rather than mRNA level. In mechanism, circOAS3 knockdown suppressed the activation of JNK/STAT3/NF-κB signaling pathways and blocked the nuclear accumulation of Hsc70 as well as phosphorylated STAT3/JNK/NF-κB as a result. Phenotypically, circOAS3 or Hsc70 silencing down-regulated the protein levels of IL-6 thus reducing psoriatic inflammation in vitro. In conclusion, interaction between circOAS3 and Hsc70 modulates the proliferation and psoriatic inflammation of HaCaT and Ker-CT cells through the JNK/STAT3/NF-κB signaling pathways, suggesting that circOAS3 or Hsc70 may be a promising therapeutic target for psoriasis.
Short Term Clinical Outcomes of Intracranial Pressure Monitor Placement in Severe Traumatic Brain Injury
Authors: Foote Christopher , Doan Xuan-Lan , Guice Jordan , Cruz Bianca , Vanier Cheryl , Betancourt Alejandro , Palacio Carlos 
Published: February 2022

Abstract
Background Intracranial pressure (ICP) monitoring has been recommended as a guiding tool for ICP treatment; however, data suggests invasive ICP monitoring had no better outcomes than those patients without it. We hypothesized that there is no difference in short term outcomes in patients with severe traumatic brain injury (TBI) who received invasive ICP monitoring compared to those who did not.Methods The trauma registry of a community Level II trauma center was queried from January 2015 to June 2020. Patients with severe TBI identified as Glasgow Coma Scale (GCS) ≤8 upon admission with an abnormal computed tomography (CT) scan, and those meeting Brain Injury Guideline (BIG) 3 (severe) were included. The data was analyzed in a logistic regression model to predict mortality, and a linear model to predict (log-transformed) hospital and ICU length of stay (LOS). Analyses were done in Rv4.0.2software.Results A total of 7,787 trauma patients were admitted during the study period, 592 were found to have GCS≤8 and of those, 118 met inclusion criteria. Forty-seven percent (n=55) received invasive ICP monitoring and 53 percent (n=63) did not. The majority (n=78, 66%) of patients were male. Median age was 35 for the ICP monitored group and 54 for the group with no ICP monitoring. The median GCS was 3 (IQR= 3,6) and the median ISS was 25 (IQR=17,26 or 27) for both groups. The ICU LOS was 5.3 days and hospital LOS 6.2 days longer for patients with ICP monitor compared to those without ICP monitor (p=0.001). The mortality rate of patients who received an ICP monitor was 19 in 55 (35%) compared to 27 of 63 (42%) for those who did not (p=0.84).Conclusions Patients with severe traumatic brain injury who received invasive ICP monitors had an increased ICU and hospital length of stay and no mortality difference when compared to those who did not. The use of an ICP monitor did not improve outcomes in this population of severe TBI patients, particularly for those who did not require neurosurgery.Level of Evidence: Level IV
Trajectories of Maternal Depressive Symptoms From Pregnancy to First Six Months Postpartum and Child Neurodevelopment at Eight Months
Authors: Li Xiuxiu , Liu Xuemei , Wei Min , Liu Xuhua , Shi Xiaojun , Zhu Yanna , Gao Rui 
Published: February 2022

Abstract
Background:Maternal depression was an increasing risk of child neurodevelopment difficulties. However, maternal depression was always chronic and recurrent, and few studies have explored the association between the severity and duration of maternal depression and child development. We aimed to explore the relationship between trajectories of maternal depressive symptoms from pregnancy to the first six months postpartum and child development at eight months.Methods:Data was collected from 988 mother-child pairs who participated in Shenzhen Birth Cohort Study. Maternal depressive symptoms were evaluated by the Edinburgh Postnatal Depression Scale (EPDS) at four points: late pregnancy, 1 month, 3 months, and 6 months postpartum. Child emotional and behavioral developments were assessed by Ages and Stages Questionnaires: Social-Emotional (ASQ-SE) and Ages and Stages Questionnaires-Third Edition (ASQ-3) at 8 months postpartum. Latent profile class analysis (LPA) was used to identify the trajectories of maternal depressive symptoms. Univariate and multivariate linear regression were conducted to explore the association between the depressive symptoms trajectories and child development.Results:Four trajectories of maternal depressive symptoms were identified by LPA: low(n=605), subclinical(n=93), moderate-low and increasing(n=255) and persistent high (54). Multivariable regressions showed that children of mothers assigned to persistent high depressive symptoms were more likely to have low scores in ASQ-3 total, three ASQ-3 domains (fine, problem-solving, and personal-society motor) and ASQ-se. Children of mothers assigned to class2 were more likely to have lower scores in ASQ-3 total, two ASQ-3 domains (communication motor and gross motor) and ASQ-se, compared to children of mothers assigned to class1. Risk factors identified in the multi-model included low birth weight, sleep quality at late pregnancy, low education level, and breastfeeding at 3month.Conclusion:The impact of high levels of maternal depression symptoms on the increased risk of child developmental delay highlights the importance of early intervention and addressing maternal depression from pregnancy through early childhood. These findings draw attention to the need to move beyond a “depressed/not depressed” approach to screening for depression in the perinatal period.
Genotyping by sequencing reveals genetic relatedness and duplicates amongst local cassava (Manihot esculenta Crantz) landraces and improved genotypes in Kenya
Authors: Orek Charles , Kyallo Martina , Oluwaseyi Shorinola , Yao Nasser 
Published: February 2022

Abstract
Background: Future demand for cassava is expected to increase to mitigate climatic changes, sustain food security and provide raw materials for industry. To meet these demands, adoption of modern omics methods ensures reliability, precision and timely delivery of more productive and resilient varieties. Therefore the purpose of this study was to contribute towards accurate identification of cassava accessions from a mix of duplicate clones, diverse local landraces (LARs) and improved genotypes (IMGs) in farmer fields. This is vital for cassava breeding. Results: A total of 112 germplasms sampled through a field survey in major cassava growing regions of Kenya, were genotyped using single nucleotide polymorphisms (SNPs) markers generated through genotyping-by-sequencing (GBS) approach. Of the 33672 SNPs, 88% were anchored onto chromosomes, 3% in scaffolds and 9% could not be mapped. LD pruning and identity by state matrix estimation revealed 5808 SNPs that were used for hierarchical clustering and ADMIXTURE analysis for ancestries. Considering a sub-population of 2 - 20, a 5-fold cross-validation procedure identified 14 subpopulations present in the population from which the population structure was modeled. Approximately 48% of the germplasms were classified into 17 independent clusters as identical clones or duplicates. The remaining 52% formed admixtures and hence unique or non-duplicated clones; reducing the total number of samples surveyed from 112 to 73. Of the duplicates, 10 clusters were formed from LARs, four from IMGs, and three from a mix of both LARs and IMGs. The major and minor clusters contained 8 and 2 accessions, respectively. About 71% of clusters contained accessions from the same geographical region while 29% had accessions from different regions. The results revealed genetic relationships amongst LARs and IMGs. Duplication of LARs was attributed to historical sharing or exchange of planting materials by farmers while duplicates of IMGs could be attributed to convergent evolution, selection, or sharing of common parentage. The high number of admixtures or unique clones implied minimal loss of genetic diversity. Geographical restriction of clusters adduced to the minimal movement of planting materials across the country, perhaps linked to either inefficient seed distribution system or disease-driven quarantine measures. Conclusions: GBS was successfully used to study the genetic relatedness of cassava genetic resources and variety identification in farmer fields. This omics approach and data herein generated could be adopted by breeders and other stakeholders in designing efficient and effective cassava improvement programs which might include the development of a core set of diagnostic markers for quality assurance, disease resistance, and targeted genomic profiling in cassava.
Exploring key genes and potential therapeutic and predictive targets between pyroptosis genes and adult extent of malignant glioma based on bioinformatics analysis
Authors: Yuan Zhengbo , Li Chenglong , Wang Qingbo , Wei Qi , Xiong Fengzhen , Li Zefu 
Published: February 2022

Abstract
Background: Adult glioma is the most common primary nervous system tumor, and there is a direct link between the grade of glioma and the prognosis of the patient. Furthermore,its treatment is still very challenging. Pyroptosis is another research direction that has made breakthroughs in recent years, and it has been confirmed that it plays an important role in a variety of tumors. We are currently focusing on analyzing the data and clinical data of a large number of pyroptosis genes, exploring the regulatory mechanism of tumor cell pyroptosis and the potential role of pyroptosis in cancer, in order to explore potential cancer diagnosis and treatment markers, for The pursuit of personalized or precise treatment provides new ideas and directions.Design: Bioinformatics analysis of GEO database,TCGA database and GSEA data.Methodology: Differential gene expression, Prognostic Network Construction, Construction of a prognostic model, Differential analysis of tumor microenvironment, immune cell expression, Tumor mutation burden correlation analysis, stem cell correlation analysis, drug sensitivity analysisConclusions: We have identified differential genes with high mutation frequencies in adult gliomas, as well as key genes associated with cell scorch and differentially expressed in different extent of malignant glioma, followed by theoretical validation and construction of prognostic models and assessment of high- and low-risk, and analysis of immune infiltration, tumor mutational load, tumor microenvironment, stem cell relevance, and drug sensitivity, revealing potential prognostic and predictive targets.
Floppy hydrated salt microcrystals
Authors: Shahidzadeh Noushine , Wijnhorst Rozeline , Demmenie Menno , Jambon-Puillet Etienne , Ariese Freek , Bonn Daniel 
Published: February 2022

Abstract
The crystalline structure of minerals due to the highly ordered assembly of its constituent atoms, ions or molecules confers a considerable hardness and brittleness to the materials. As a result, they are generally subject to fracture. Here we report that microcrystals of natural inorganic salt hydrates such as sodium sulfate decahydrate (Na2SO4 • 10H2O) and magnesium sulfate hexahydrate (MgSO4 • 6H2O) can behave remarkably differently: instead of having a defined faceted geometrical shape and being hard or brittle, they lose their facets and become soft and deformable when in contact with their saturated salt solution at their deliquescence point. As a result, the hydrated crystals simultaneously behaves as crystalline and liquid-like. We show that the observed elasticity is a consequence of a trade-off between the excess capillary energy introduced by the deformation from the equilibrium shape and viscous flow over the surface of the microcrystals. This surprising, unusual mechanical properties reported here reveals the role of the water molecules present in the crystalline structure. Although many compounds can incorporate water molecules in their crystalline frameworks, the relationship between the different hydrates and anhydrate crystal forms are still poorly investigated. Our results on the floppy behaviour of such crystalline structure reveals some unexplored properties of water molecules entrapped in the crystalline structure and can open novel routes for their application in various fields such as pharmaceutical sciences , thermal energy storage and even the traceability of water on Mars
The protective effect of Vitamin A Palmitate Eye Gel on ocular surface during general anesthesia surgery: a randomized clinical trial
Authors: Li Siyuan , Lei Guiyu , Liu Ying , Tian Lei , Jie Ying , Wang Guyan 
Published: February 2022

Abstract
Background: General anesthesia was associated with tear production decreased, usually accompanied by ophthalmological complications, such as dry eye and corneal injuries. Patients suffering from such conditions developed symptoms such as conjunctival injection, eye pain, and tearing. Protective measures including taping eyelid closed and applying lubricating tears during general anesthesia have long been advocated to reduce the incidence of corneal abrasion. The study aimed to investigate the change of tear production associated with general anesthesia, and the protective effect of Vitamin A Palmitate Eye Gel on ocular surface during general anesthesia, including the subjective symptoms and objective signs. Methods: The study was designed as a double-blind randomized clinical trial. Each participant who was ready for non-ophthalmic general anesthesia surgery randomly received Vitamin A Palmitate Eye Gel and taping for one eye (Group A, n=60), and taping alone for the other eye (Group B, n=60) though random number table. Symptom assessment in dry eye (SANDE) score, tear film break-up time (TBUT), corneal fluorescein staining (CFS) score and Schirmer tear test I (STT-1) were assessed under hand-held slit lamp before anesthesia (T0), 0.5h postoperative (T1) and 24h postoperative (T2). Results: At 0.5h postoperative, both groups demonstrated increase in CFS score (P<0.05 in Group A and P<0.01 in Group B), and the participants in Group A showed numerically less corneal abrasion than that of in Group B. STT-1 observed in Group A was statistically increased (P<0.05), while that of in Group B was statistically decreased (P<0.001). The changes between two groups were statistically significant (P<0.001). At 24h postoperative, both CFS score and STT-1 almost returned to baseline level in two groups. SANDE score and TBUT showed little change at 0.5h and 24h postoperative in two groups (P>0.05). Conclusion: Vitamin A Palmitate Eye Gel were effective in ocular surface protection and aqueous supplementation during general anesthesia. Trial registration: The study was registered with the Chinese Clinical Trial Registry (ChiCTR2100052140). Registered 20 October,2021. http://www.chictr.org.cn/showproj.aspx?proj=135706 Trial registration: ISRCTN, ISRCTN12345678., http://www.isrctn.com/ISRCTN12345678
Breast feeding practice in neonatal intensive care unit of Ibn Rochd teaching hospital in Casablanca
Authors: Sylla AK. , Lehlimi M. , Badre A. , Hajjaji S. , Lyazidi S. , Ameayou S. , Chemsi M. , Habzi A. , Benomar S. , Nani S. , Hassoune S. 
Published: February 2022

Abstract
Background: In Morocco the breast feeding (exclusive) prevalence has decreased from 51% in 1992 to 35% in 2018. This prevalence was lower in neonatal intensive care unit (NICU) with 12.4% in 2014. The aim of this study was to estimate the prevalence and identify the associated factors of breastfeeding (BF) practice in NICU of Casablanca Ibn Rochd teaching hospital.Method:A cross sectional study was performed between 04 January and 26 June 2021 in NICU. We included Moroccan couples mother/newborn who can practice the BF presents during the study period. We used face to face interview using pretested questionnaire. Logistic regression was used to test association between breastfeeding (BF) practice and potential associated factors. Factors with p ≤ 0.05 were considered as associated factors of BF practice. Data were analyzed using R 3.6.3 Findings: We included 170 couple mother/newborn. Around 74% of mothers practiced partial breastfeeding. The mother factors associated with BF practice were: education level (OR=0,10; 95%CI : 0,01-0,87 ;p=0,037781), family monthly income (OR=4,3 ; 95%CI: 1,12-16 ,56 ; p=0,033606) and marital status (OR=14,3 ; 95%CI:1,37-148,43 ; p=0,025853). The newborns’ factors associated to BF practice were: hospital stay length (OR= 1,12 95%CI: 1,00-1,25 ; p=0,047726) and hospitalization motif (OR=0,27 ; 95%CI: 0,076-0,95 ; p=0,042085). And healthcare facility factors associated to BF practice was: healthcare staff support: (OR=6,7 ; 95%CI:2,2-20,54 ; p=0,000891) .Conclusion: The newborn hospitalized for respiratory distress from single mothers with lower education level and social standard who, don’t have enough (or any) support from healthcare staff are the ones who receive less breast milk in NICU of Casablanca Ibn Rochd teaching hospital.
Optical stimulation of inferior temporal cortex induces object-specific visual distortions.
Authors: Azadi Reza , Bohn Simon , Lopez Emily , Lafer-Sousa Rosa , Wang Karen , Eldridge Mark , Afraz Arash 
Published: February 2022

Abstract
To be able to effectively restore vision by direct cortical stimulation, we need to understand the perceptual events induced by stimulation of high-level visual cortices. We trained macaque monkeys to detect and report optogenetic impulses delivered to their inferior temporal cortices. In a series of experiments, we observed that detection of cortical stimulation highly depends on the choice of images presented to the eyes and that detection of cortical stimulation is most difficult when the animal fixates on a blank screen. We show that local stimulation of object selective parts of the visual cortex induce perceptual events that are easy to detect as object-dependent distortions of the concurrent contents of vision. These findings invite expanding the scope of visual prosthetics beyond the primary visual cortex.