bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dust dynamics in ramses – I. Methods and turbulent acceleration
Authors: Moseley Eric R , Teyssier R , Draine B T 
Published: November 2022

ABSTRACT
Supernova ejecta and stellar winds are believed to produce interstellar dust grains with relatively large sizes. Smaller grains can be produced via the shattering of large grains that have been stochastically accelerated. To understand this stochastic acceleration, we have implemented novel magnetohydrodynamic (MHD) particle-in-cell methods into the astrophysical fluid code ramses. We treat dust grains as a set of massive ‘superparticles’ that experience aerodynamic drag and Lorentz force. We subject our code to a range of numerical tests designed to validate our method in different physical conditions, as well as to illustrate possible mechanisms by which grains can be accelerated. As a final test as well as a foundation for future work, we present the results of decaying dusty MHD turbulence simulations with grain parameters chosen to resemble 1–2 μm grains in typical cold neutral medium conditions. We find that in these conditions, these grains can be effectively accelerated to well beyond their shattering velocities. This is true for both electrically charged and neutral grains. While the peak of the gas-grain relative drift velocity distribution is higher for neutral grains, the drift velocity distribution of charged grains exhibits an extended exponential tail out to much greater velocities. Even so, the shapes of the distributions are such that the extra gas-grain coupling provided by the Lorentz force offers grains relative protection from shattering. We also discuss the connection between our simulations and the relatively pristine ∼μm-sized pre-solar grains that do not appear to have undergone significant wear in their lifetimes.
Modelling internal structure of differentiated asteroids via data-driven approach
Authors: Liang Yuying , Ozaki Naoya , Kawakatsu Yasuhiro , Fujimoto Masaki 
Published: November 2022

ABSTRACT
This paper is devoted to an interdisciplinary method modelling the internal structure of differentiated asteroids via a data-driven approach called invertible neural networks (INNs). The model estimation of the internal structure can be generalized as an inverse problem of estimating internal parameters from a set of observations. Previous works (e.g. Park et al. 2014; Takahashi and Scheeres 2014) used the full gravity field data measures to derive the heterogeneous mass distribution. However, in our method, only the flight state of the spacecraft is adopted as the observation data. Since the internal parameters may not be uniquely determined, typical feedforward neural networks cannot simply be applied to such an inverse problem. The INNs adopted in this paper can ‘read’ the interior information from a flight trajectory of the spacecraft directly. The INNs are employed to establish the two-directional mapping between the group of physical parameters and the set of flight state observations of position and velocity. The INNs are trained in a bi-directional way using four losses. Finally, the performances of the trained networks are shown in both overfit and underfit situations where the internal structure of asteroids can be estimated by this INNs-based method accurately and effectively. The results also show that even when the degeneracy occurs, the true solution still falls inside the estimation distribution.
Gravitational waves from small spin-up and spin-down events of neutron stars
Authors: Yim Garvin , Jones D I 
Published: November 2022

ABSTRACT
It was recently reported that there exists a population of ‘glitch candidates’ and ‘antiglitch candidates’ which are effectively small spin-ups and spin-downs of a neutron star with magnitudes smaller than those seen in typical glitches. The physical origin of these small events is not yet understood. In this paper, we outline a model that can account for the changes in spin, and crucially, is independently testable with gravitational wave observations. In brief, the model posits that small spin-up/spin-down events are caused by the excitation and decay of non-axisymmetric f-modes which radiate angular momentum away in a burst-like way as gravitational waves. The model takes the change in spin frequency as an input and outputs the initial mode amplitude and the signal-to-noise ratio achievable from gravitational wave detectors. We find that the model presented here will become falsifiable once third generation gravitational wave detectors, like the Einstein Telescope and Cosmic Explorer, begin taking data.
Sub-mm/mm optical properties of real protoplanetary matter derived from Rosetta/MIRO observations of comet 67P
Authors: Bürger Johanna , Glißmann Thilo , Lethuillier Anthony , Bischoff Dorothea , Gundlach Bastian , Mutschke Harald , Höfer Sonja , Wolf Sebastian , Blum Jürgen 
Published: November 2022

ABSTRACT
Optical properties are required for the correct understanding and modelling of protoplanetary and debris discs. By assuming that comets are the most pristine bodies in the Solar system, our goal is to derive optical constants of real protoplanetary material. We determine the complex index of refraction of the near-surface material of comet 67P/Churyumov–Gerasimenko by fitting the sub-millimetre/millimetre observations of the thermal emission of the comet’s sub-surface made by the Microwave Instrument for the Rosetta Orbiter with synthetic temperatures derived from a thermophysical model and radiative-transfer models. According to the two major formation scenarios of comets, we model the sub-surface layers to consist of pebbles as well as of homogeneously packed dust grains. In the case of a homogeneous dusty surface material, we find a solution for the length-absorption coefficient of α ≈ 0.22 cm−1 for a wavelength of 1.594 mm and α ≥ 3.84 cm−1 for a wavelength of 0.533 mm and a constant thermal conductivity of 0.006 W m−1 K−1. For the pebble scenario, we find for the pebbles and a wavelength of 1.594 mm a complex refractive index of $n = (1.074 \!-\! 1.256) + \mathit{i} \, (2.580 \!-\! 7.431)\times 10^{-3}$ for pebble radii between 1 and 6 mm. Taking into account other constraints, our results point towards a pebble make-up of the cometary sub-surface with pebble radii between 3 and 6 mm. The derived real part of the refractive index is used to constrain the composition of the pebbles and their volume filling factor. The optical and physical properties are discussed in the context of protoplanetary and debris disc observations.
Energy wrinkles and phase-space folds of the last major merger
Authors: Belokurov Vasily , Vasiliev Eugene , Deason Alis J , Koposov Sergey E , Fattahi Azadeh , Dillamore Adam M , Davies Elliot Y , Grand Robert J J 
Published: November 2022

ABSTRACT
Relying on the dramatic increase in the number of stars with full 6D phase-space information provided by the Gaia Data Release 3, we resolve the distribution of the stellar halo around the Sun to uncover signatures of incomplete phase-mixing. We show that, for the stars likely belonging to the last massive merger, the (vr, r) distribution contains a series of long and thin chevron-like overdensities. These phase-space substructures have been predicted to emerge following the dissolution of a satellite, when its tidal debris is given time to wind up, thin out, and fold. Such chevrons have been spotted in external galaxies before; here, we report the first detection in our own Milky Way. We also show that the observed angular momentum Lz distribution appears more prograde at high energies, possibly revealing the original orbital angular momentum of the in-falling galaxy. The energy distribution of the debris is strongly asymmetric with a peak at low E – which, we surmise, may be evidence of the dwarf’s rapid sinking – and riddled with wrinkles and bumps. We demonstrate that similar phase-space and (E, Lz) substructures are present in numerical simulations of galaxy interactions, both in bespoke N-body runs and in cosmological hydrodynamical zoom-in suites. The remnant traces of the progenitor’s disruption and the signatures of the on-going phase-mixing discovered here will not only help to constrain the properties of our Galaxy’s most important interaction, but also can be used as a novel tool to map out the Milky Way’s current gravitational potential and its perturbations.
Predicting sub-millimetre flux densities from global galaxy properties
Authors: Cochrane R K , Hayward C C , Anglés-Alcázar D , Somerville R S 
Published: November 2022

ABSTRACT
Recent years have seen growing interest in post-processing cosmological simulations with radiative transfer codes to predict observable fluxes for simulated galaxies. However, this can be slow, and requires a number of assumptions in cases where simulations do not resolve the interstellar medium (ISM). Zoom-in simulations better resolve the detailed structure of the ISM and the geometry of stars and gas; however, statistics are limited due to the computational cost of simulating even a single halo. In this paper, we make use of a set of high-resolution, cosmological zoom-in simulations of massive ($M_{\star }\gtrsim 10^{10.5}\, \rm {M_{\odot }}$ at z = 2), star-forming galaxies from the FIRE suite. We run the skirt radiative transfer code on hundreds of snapshots in the redshift range 1.5 &lt; z &lt; 5 and calibrate a power-law scaling relation between dust mass, star formation rate, and $870\, \mu \rm {m}$ flux density. The derived scaling relation shows encouraging consistency with observational results from the sub-millimetre-selected AS2UDS sample. We extend this to other wavelengths, deriving scaling relations between dust mass, stellar mass, star formation rate, and redshift and sub-millimetre flux density at observed-frame wavelengths between $\sim \! 340$ and $\sim \! 870\, \mu \rm {m}$. We then apply the scaling relations to galaxies drawn from EAGLE, a large box cosmological simulation. We show that the scaling relations predict EAGLE sub-millimetre number counts that agree well with previous results that were derived using far more computationally expensive radiative transfer techniques. Our scaling relations can be applied to other simulations and semi-analytical or semi-empirical models to generate robust and fast predictions for sub-millimetre number counts.
Euclid detectability of pair instability supernovae in binary population synthesis models consistent with merging binary black holes
Authors: Tanikawa Ataru , Moriya Takashi J , Tominaga Nozomu , Yoshida Naoki 
Published: November 2022

ABSTRACT
We infer the expected detection number of pair instability supernovae (PISNe) during the operation of the Euclid space telescope based on binary population models. Our models reproduce the global maximum at the primary BH mass of ∼9–10 M⊙ and the overall gradient of the primary BH mass distribution in the binary BH merger rate consistent with recent observations. We consider different PISN conditions depending on the 12C(α, γ)16O reaction rate. The fiducial and 3σ models adopt the standard and 3σ smaller reaction rates, respectively. Our fiducial model predicts that Euclid detects several hydrogen-poor PISNe. For the 3σ model, detection of ∼1 hydrogen-poor PISN by Euclid is expected if the stellar mass distribution extends to Mmax  = 600 M⊙, but the expected number becomes significantly smaller if Mmax  = 300 M⊙. We may be able to distinguish the fiducial and 3σ models by the observed PISN rate. This will help us to constrain the origin of binary BHs and the reaction rate, although there remains a degeneracy between Mmax  and the reaction rate. PISN ejecta mass estimates from light curves and spectra obtained by follow-up observations would be important to disentangle the degeneracy.
SEVA 4.0: an update of the Standard European Vector Architecture database for advanced analysis and programming of bacterial phenotypes
Authors: Martínez-García Esteban , Fraile Sofía , Algar Elena , Aparicio Tomás , Velázquez Elena , Calles Belén , Tas Huseyin , Blázquez Blas , Martín Bruno , Prieto Clara , Sánchez-Sampedro Lucas , Nørholm Morten H H , Volke Daniel C , Wirth Nicolas T , Dvořák Pavel , Alejaldre Lorea , Grozinger Lewis , Crowther Matthew , Goñi-Moreno Angel , Nikel Pablo I , Nogales Juan , de Lorenzo Víctor 
Published: November 2022

Abstract
The SEVA platform (https://seva-plasmids.com) was launched one decade ago, both as a database (DB) and as a physical repository of plasmid vectors for genetic analysis and engineering of Gram-negative bacteria with a structure and nomenclature that follows a strict, fixed architecture of functional DNA segments. While the current update keeps the basic features of earlier versions, the platform has been upgraded not only with many more ready-to-use plasmids but also with features that expand the range of target species, harmonize DNA assembly methods and enable new applications. In particular, SEVA 4.0 includes (i) a sub-collection of plasmids for easing the composition of multiple DNA segments with MoClo/Golden Gate technology, (ii) vectors for Gram-positive bacteria and yeast and [iii] off-the-shelf constructs with built-in functionalities. A growing collection of plasmids that capture part of the standard—but not its entirety—has been compiled also into the DB and repository as a separate corpus (SEVAsib) because of its value as a resource for constructing and deploying phenotypes of interest. Maintenance and curation of the DB were accompanied by dedicated diffusion and communication channels that make the SEVA platform a popular resource for genetic analyses, genome editing and bioengineering of a large number of microorganisms.
RESET-PKD: a pilot trial on short-term ketogenic interventions in autosomal dominant polycystic kidney disease
Authors: Oehm Simon , Steinke Konstantin , Schmidt Johannes , Arjune Sita , Todorova Polina , Heinrich Lindemann Christoph , Wöstmann Fabian , Meyer Franziska , Siedek Florian , Weimbs Thomas , Müller Roman-Ulrich , Grundmann Franziska 
Published: November 2022

ABSTRACT

Background
Ketogenic dietary interventions (KDI) have been shown to be effective in animal models of polycystic kidney disease (PKD), but data from clinical trials are lacking.

Methods
Ten autosomal dominant PKD (ADPKD) patients with rapid disease progression were enrolled at visit V1 and initially maintained a carbohydrate-rich diet. At V2, patients entered one of the two KDI arms: a 3-day water fast (WF) or a 14-day ketogenic diet (KD). At V3, they resumed their normal diet for 3–6 weeks until V4. At each visit, magnetic resonance imaging kidney and liver volumetry was performed. Ketone bodies were evaluated to assess metabolic efficacy and questionnaires were used to determine feasibility.

Results
All participants [KD n = 5, WF n = 5; age 39.8 ± 11.6 years; estimated glomerular filtration rate 82 ± 23.5 mL/min/1.73 m2; total kidney volume (TKV) 2224 ± 1156 mL] were classified as Mayo Class 1C–1E. Acetone levels in breath and beta-hydroxybutyrate (BHB) blood levels increased in both study arms (V1 to V2 average acetone: 2.7 ± 1.2 p.p.m., V2 to V3: 22.8 ± 11.9 p.p.m., P = .0006; V1 to V2 average BHB: 0.22 ± 0.08 mmol/L, V2 to V3: 1.88 ± 0.93 mmol/L, P = .0008). Nine of 10 patients reached a ketogenic state and 9/10 evaluated KDIs as feasible. TKV did not change during this trial. However, we found a significant impact on total liver volume (ΔTLV V2 to V3: −7.7%, P = .01), mediated by changes in its non-cystic fraction.

Conclusions
RESET-PKD demonstrates that short-term KDIs potently induce ketogenesis and are feasible for ADPKD patients in daily life. While TLV quickly changed upon the onset of ketogenesis, changes in TKV may require longer-term interventions.
Infectious Complications of Abortion
Authors: Wall L Lewis , Yemane Awol 
Published: November 2022

Abstract
This article reviews the infectious complications of abortion (both spontaneous and induced) and the management of this condition. The key points are: (1) Making abortion illegal does not reduce its incidence or prevalence; rather, it only makes abortions unsafe, increasing the likelihood of infectious complications. (2) Timely recognition of developing sepsis in the pregnant patient is critical. This requires constant vigilance and a high index of suspicion. (3) Rapid intravenous administration of broad-spectrum antibiotics targeted to the likely intrauterine source of infection as soon as sepsis is diagnosed is critical to prevent severe sepsis, septic shock, and multisystem organ failure. (4) The mainstay of treatment is prompt evacuation of any residual products of conception from within the uterine cavity under broad-spectrum antibiotic cover targeting the likely intrauterine source of infection. (5) Prompt engagement of specialists in both critical care and obstetrics-gynecology is necessary to optimize outcomes in patients with septic abortion.
An usual case of bilateral deep venous thrombosis with associated pulmonary embolus
Authors: Plumptre Hannah , Giannoudi Marilena , Kurian John 
Published: November 2022

ABSTRACTCongenital absence of the inferior vena cava (IVC) triggers collateral vessel growth to drain the peripheries and abdominal organs. This causes venous stasis and increases the risk of deep vein thrombosis (DVT) and pulmonary embolism. Typically, patients with absent IVCs present before 30 years of age, with bilateral DVT symptoms triggered by intense exercise. The abnormality can remain undetected as computed tomography imaging is not usually performed. Due to the increased risk of clotting, these patients should be on life-long anticoagulation. Raising clinical awareness of this condition, to ensure appropriate investigations and treatment, is important.
Cannula removal with hemostasis secured by thoracoscopic support for accidental central vein puncture: a case report
Authors: Takamori Satoshi , Oizumi Hiroyuki , Nakamura Megumi , Suzuki Jun , Takeshi Akihiro , Shiono Satoshi 
Published: November 2022

ABSTRACT
Central venous catheterization is a commonly used procedure for disease management. However, the procedure is not without risks of severe morbidity. We herein report hemostasis for accidental venous puncture using thoracoscopy. A 44-year-old man with short bowel syndrome and chronic renal failure required central venous catheterization for nutritional management and hemodialysis. Right internal jugular vein puncture was performed under ultrasonographic guidance, and the guidewire was inserted into the right atrium under fluoroscopic guidance. However, the operator inadvertently perforated the vein, and the thoracic cavity was entered while inserting the introducer. The patient’s vital signs were stable; therefore, we performed emergency surgery after computed tomography and achieved hemostasis through thoracoscopic surgery. Sufficient caution should be exercised while inserting central venous catheters through a thrombosed internal jugular vein. In some instances of catheter-induced vessel injury, combined surface and thoracoscopic hemostasis may be a reliable and minimally invasive management option.
Salmonella typhi: a rare cause of neck abscess
Authors: Doya Leen , Doya Lama , Ghanem Abdulmoniem 
Published: November 2022

ABSTRACT
Salmonella typhi neck abscess represents a rare cause of focal salmonellosis. Most of the cases in the literature reviews were reported in immunosuppression adults; just two of them were in children. Herein we report a case of 7-year old healthy girl with a neck abscess caused by S. typhi. The patient was diagnosed according to serological and radiological findings. Incision and drainage of the abscess accompanied by broad-spectrum antibiotics were performed for treatments. S. typhi should be kept in mind as a cause of neck abscesses.
Primary splenic T-cell/histiocyte-rich B-cell lymphoma in a patient with recurrent hairy cell leukemia: a case report
Authors: Ahmad Tagrid Younes , Al Houri Hasan Nabil , Jomaa Sami , Assad Wisam , Addeen Sarah Zaher 
Published: November 2022

ABSTRACT
T-cell/histiocyte-rich B-cell lymphoma is a high-grade, morphologic variant of diffuse large B-cell lymphoma. T-cell/histiocyte-rich B-cell lymphoma. It is rare as a primary splenic involvement and is usually reported as a second malignancy after hairy cell leukemia. Here, we report the first case that describes the occurrence of primary splenic T-cell/histiocyte-rich B-cell lymphoma in a patient with a previous diagnosis of recurrent hairy cell leukemia. A 53-year-old male patient was diagnosed with hairy cell leukemia in 1996 and achieved complete remission with Pentostatin. Then, recurrence of hairy cell leukemia was diagnosed in 2015 and treated with Cladribine. In 2016, he presented with B symptoms and hypersplenism. Therapeutic and diagnostic splenectomy was performed. Histopathological study with immunohistochemistry evaluation revealed the presence of T-cell/histiocyte-rich B-cell lymphoma. Therefore, second malignancies should be considered in patients with a previous neoplasm when symptoms recur or develop.
Nab-paclitaxel Followed by Dose-dense Epirubicin/Cyclophosphamide in Neoadjuvant Chemotherapy for Triple-negative Breast Cancer: A Phase II Study
Authors: Liu Yin , Fan Lei , Wang Zhong-Hua , Shao Zhi-Ming 
Published: November 2022

Abstract

Background
The anti-tumor activity of nab-paclitaxel followed by epirubicin/cyclophosphamide (EC) as neoadjuvant chemotherapy (NAC) in Asian patients remain unclear, particularly in the aggressive subtype triple-negative breast cancer (TNBC). This study aimed to evaluate the efficacy and safety of this NAC regimen in TNBC.

Methods
In this Simon’s two-stage, phase II study, treatment-naïve patients with unilateral primary invasive TNBC were enrolled. Eligible patients received nab-paclitaxel 125 mg/m2 weekly on day 1 for 12 weeks, followed by dose-dense EC (epirubicin 90 mg/m2; cyclophosphamide 600 mg/m2) on day 1 for four 2-week cycles. The primary endpoint was the total pathological complete response (tpCR, ypT0/is ypN0) rate.

Results
A total of 55 eligible patients were enrolled and treated. After NAC, tpCR and breast pathological complete response were respectively observed in 43.1% (95% CI, 29.3-57.8) and 49.0% (95% CI, 34.8-63.4) of 51 evaluable patients for pathological response evaluation. 44 had an objective response as their best response (80.0%; 95% CI, 67.0-89.6). No correlations between clinicopathological variables and pathological/clinical response were observed. Grade 3 or more adverse events (AEs) occurred in 63.6% of 55 patients. The most frequent AEs were alopecia. No treatment-related surgical delay or death occurred.

Conclusion
Nab-paclitaxel followed by dose-dense EC as NAC demonstrates promising anti-tumor activity and acceptable tolerability for patients with TNBC. (ClinicalTrials.gov Identifier: NCT03799679).
Mathematics: Method Without Metaphysics
Authors: Landry Elaine 
Published: November 2022

AbstractI use my reading of Plato to develop what I call as-ifism, the view that, in mathematics, we treat our hypotheses as if they were first principles and we do this with the purpose of solving mathematical problems. I then extend this view to modern mathematics showing that when we shift our focus from the method of philosophy to the method of mathematics, we see that an as-if methodological interpretation of mathematical structuralism can be used to provide an account of the practice and the applicability of mathematics while avoiding the conflation of metaphysical considerations with mathematical ones.