bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness analysis of neratinib plus capecitabine against lapatinib plus capecitabine for HER2-Positive metastatic breast cancer
Authors: Shao Jiangbo , He Yu , Zhan Cuiping , Jin Ying , Jin Chunxiang 
Published: October 2022

Abstract
Background
Neratinib plus capecitabine(N + C)has a good effect for HER2-positive metastatic breast cancer (MBC), but considering these tradeoffs in quality of life and cost, the optimal choice of treatment sequencing is unclear. Cost-effectiveness analysis can clearly quantify such tradeoffs to make more informed decisions. Our objective was to evaluate the social cost-effectiveness of the N + C regimen for HER2 positive MBC.
METHODS
Clinical data were extracted from a randomized controlled trial, NALA (NCT01808573). Patients were randomized into the N + C group or the lapatinib plus capecitabine (L + C) group. A Markov model was established with a 21-day cycle length. Costs were acquired from local hospitals, effect parameters included quality-adjusted life year (QALY) and incremental cost-effectiveness ratio (ICER).
RESULTS
In the main analysis, the QALY in N + C is 0.04492 higher than that in L + C (N + C, 0.62954 QALY; L + C, 0.58462 QALY). The ICER between N + C and L + C was − 1,796,801.93 CNY/QALY. In the subanalysis, the QALY in N + C is 0.05643 higher than that in L + C (N + C, 0.65047 QALY; L + C, 0.59404 QALY) in the Asian group. The ICER between N + C and L + C was − 1,584,528.96 CNY/QALY. Sensitivity analyses indicated the stability of the model and the impact of utility.
CONCLUSION
N + C was cost-effective compared with L + C for HER2 positive MBC.
Numerical
Investigation of a Thermoelastic Model for a Propagating Phase Boundary
Authors: Petersen Eric H. 
Published: October 2022

Abstract
A brief discussion of a numerical investigation of admissibility criteria for one-dimensional propagating phase boundaries in thermoelastic solids with nonconvex energies via viscosity-capillarity regularization, undertaken under the supervision of Prof. Fosdick. Dedicated to my teacher and friend, Roger L. Fosdick.
MSC Classification: 74J40 , 74N20 , 74S20
Pregnancy in the digital health era: exploring digital health usage amidst the COVID-19 pandemic
Authors: Caillaud Corinne , Lazarevic Natasa , Pizzuti Carol , Rosic Gillian , Boehm Céline , Williams Kathryn 
Published: October 2022

Abstract
Digital health tools such as apps are being increasingly used by women to access pregnancy-related information. Conducted during the COVID-19 pandemic, this study investigated pregnant women’s usage of digital health tools and self-monitoring behaviours. In addition, views and interest in theoretical pregnancy app features: (1) a direct patient-to-healthcare-professional communication tool and (2) a novel body measurement tool was assessed. Using a mixed methods approach, 108 pregnant women were surveyed and 15 currently or recently pregnant women were interviewed online. We found that the COVID-19 pandemic had impacts on multiple dimensions of the experiences of pregnant women including their experiences with healthcare, their relationships with themselves and their social circle. Most participants said that they would use the theoretical app features we described and also identified a gap in the availability of evidence-based educational information. Other features that they would include in a pregnancy app were a “Digital Wallet” and a desire for a holistic pregnancy app that allowed for more continuous and personalised care. The main factor that influenced how likely participants were to use pregnancy apps were concerns about data privacy and security. This study highlights the gaps and needs of pregnant women and should inform all stakeholders designing pregnancy digital healthcare. This study offers a unique insight into the experiences of pregnant women during a very particular and unique period in human history.
The Role of Fragility in Thermal Elastohydrodynamics
Authors: Bair Scott , Habchi Wassim 
Published: October 2022

Abstract
Temperature primarily influences thermal elastohydrodynamic lubrication (TEHL) through the temperature dependence of the viscosity of the liquid. The pressure and temperature dependences of viscosity increase rapidly as the glassy state is approached from the liquid state, a property known as fragility. The glass temperature increases with pressure and reaches to ordinary temperatures at TEHL pressures. It is astounding, therefore, that most TEHL analyses have ignored fragility by utilizing a viscosity correlation incapable of describing this behavior. Here, a low viscosity fragile oil is characterized for low-shear viscosity to 1.6 GPa and TEHL line contact simulations show, not only a substantial effect on friction, but significant differences in minimum film thickness when fragility is not ignored, as is customary in classical TEHL. The influence on friction manifests even under moderate load and speed conditions, while that on film thickness seems to be restricted to high loads.
A note on simple K3 singularities and families of weighted K3 surfaces
Authors: Mase Makiko 
Published: October 2022

Abstract
We discuss properties of the Seifert form for simple K3 singularities, and of the Picard lattices of families of weighted K3 surfaces. We study a collection M(ρ, δ) of K3 surfaces polarized by their Picard lattices that are in the set L(ρ, δ) of certain lattices. We also report a numerical formula that relates the Seifert form for the singularities and the Picard lattice of the family.
Intravitreal aflibercept for patients with acute nonarteritic anterior ischemic optic neuropathy: A retrospective trial
Authors: Cheng Kai-Chun , Chiu Chien-Chih , Chen Kuo-Jen , Chang Yo-Chen 
Published: October 2022

Abstract
Purpose: This study aimed to investigate whether intravitreal aflibercept was safe and effective in patients with acute nonarteritic anterior ischemic optic neuropathy (NAION). Design: A retrospective analysis of a consecutive patient series.
Methods: This was a chart study of 25 individuals with acute NAION (25 eyes). Aflibercept 2 mg/0.05 ml intravitreal injection was administered to fifteen participants. The remaining ten patients in the control group were given standard care. The researchers measured the initial visual acuity, the retinal nerve fiber layer thickness (RNFLT), and automated perimetry. During the follow-up period, the researchers measured the final visual acuity, RNFLT, automated perimetry, and side effects.
Results: The study group had a mean follow-up time of 229.73 ± 43.44 days, while the control group had 258.90 ± 62.42 days. Visual acuity and visual field assessment were significantly improved in the study group, and optical coherence tomography testing demonstrated significant disc edema resolution. The therapy results differed significantly between the two groups regarding visual outcomes (F=0.027, P=0.039) and RNFLT decrease (F=8.934, P<0.001). However, the difference in visual field alterations between the two groups was not statistically significant (F=0.724, P=0.387).
Conclusion: Intravitreal injection of aflibercept can significantly improve visual acuity and resolve disc edema in patients with acute NAION. Intravitreal aflibercept may be an alternative treatment for acute NAION. However, a large-series investigation is needed to assess the long-term therapeutic benefit and safety of intravitreal aflibercept in patients with acute NAION.
An Wolf Hunting Approach for Optimization of Tasks Scheduling in Cloud Computing
Authors: Patel Padmaja , Kakita Murali Gopal , Das Debashreet 
Published: October 2022

Abstract
Cloud computing is the most emerging technology in the era that provides scalable, distributed, elastic computer resources for the end-user using the internet.However, the Cloud Computing Networks(CCNs) fails in providing many Quality of Services(QoS) such as reliability, load balancing, resource allocation and task scheduling, security, etc out of which the most challenging task in cloud computing is task scheduling, which directly affects the operational cost and resource usage of the system.Hence,this paper proposes an advanced technique named the Wolf Hunting Approach (WHA)for further improvement of an optimal solution for searching with a multi-objective optimization technique. The implementation of WHA involves simulation based experiment and shows that WHA has better accuracy and convergence speed in seeking for optimal task scheduling. In comparison to the current meta-heuristic algorithms, it provides superior performance in utilization of system resources in the presence of large-scale and small-scale tasks. The approach is well illustrated with suitable examples
Spatial distribution, ecological risk assessment and source analysis of heavy metals pollution in urban lake sediments of Huaihe River Basin
Authors: Wu Dun , Liu Hai , Cai Guojun , Wu Jian , Gao Xia 
Published: October 2022

Abstract
In order to understand the spatial distribution, pollution characteristics, potential pollution sources and ecological risks of heavy metals in the sediments of Chengxi Lake and Chengdong Lake in Huoqiu County in the middle reaches of the Huaihe River Basin, the contents of heavy metals (As, Cd, Cr, Cu, Hg, Ni, Pb and Zn) in the sediments of Chengxi Lake and Chengdong Lake were determined. The potential sources of heavy metals in sediments were quantitatively analyzed by principal component analysis-absolute principal component fraction-multiple linear regression (PCA-APCS-MLR) receptor model. Descriptive statistics showed that the average concentration of heavy metals in lake sediments from high to low was Zn > Cr > Ni > Cu > Pb > As > Cd > Hg, which in Chengxi Lake was higher than that in Chengdong Lake. Geo-accumulation index and pollution load index all indicated that there were moderate pollutions for Cu, As, Hg, Ni and Zn. Comprehensive indexes of potential ecological risks showed that Cd and Hg exhibited the moderate potential ecological risks, the others were low risks. Mean sediment quality guideline quotient indicated that there was a moderate degree of potential adverse biological toxicity in lake sediments. Spatially, the seriously polluted contaminated were the central position of Chengxi Lake and the northeast end of Chengdong Lake. PCA-APCS-MLR revealed that that Cr, Ni, Cu and Zn were mainly from natural sources, while Cd, As, Hg and Pb elements were mainly from industrial sources and pesticide sources.
Frailty, physical performance and mortality in older patients with and without diabetic kidney disease: a longitudinal cohort study
Authors: Weng Shuo-Chun , Lin Cheng-Fu , Hsu Chiann-Yi , Lin Shih-Yi 
Published: October 2022

Abstract
Background: Declined renal function is associated with physical function impairment and frailty in a graded fashion. This study aimed to examine the relationship between renal function, frailty and physical performance with mortality in older patients with diabetes, while also determining their combined effects on patient outcome.
Methods: A longitudinal retrospective study was conducted in elderly patients with diabetes. Chronic kidney disease (CKD) was defined as an estimated glomerular filtration rate of less than 60 ml/min, while the modified Rockwood frailty index (RFI) and physical function was determined by handgrip strength (HGS). Additionally, a timed up and go (TUG) test was assessed at baseline. Kaplan-Meier survival and Cox proportional hazard analyses were used to analyze the association between CKD, frailty, physical function and mortality.
Results: For the 921 enrolled patients, their mean age was 82.0 ± 6.7 years. After a median 2.92 (interquartile range [IQR] 1.06–4.43) year follow-up, the survival rate was 67.6% and 85.5% in patients with CKD and without CKD. The mortality hazard ratio (crude HR) with CKD was 5.92 for those with an RFI higher than 0.313 (95% CI 3.44–10.18), 2.50 for a TUG time longer than 21 seconds (95% CI 1.22–5.13), and 2.67 for an HGS lower than 10.57 kg in females or 20.4 kg in males (95% CI 1.12–6.37). After multivariate adjustment, the mortality hazard ratio for an RFI ≥0.313 was 5.34 (95% CI 2.23–12.80) in CKD patients, but not in non-CKD patients. In subgroup analysis, patients experiencing CKD and frailty, or physical function impairment, had the lowest survival proportion followed by only frailty/declined physical function, only CKD, non-CKD and non-frailty/non-physical impairment.
Conclusions: CKD, frailty and physical function impairment were all associated with an increased mortality risk in older patients with diabetes, while the combined effects of these 3 factors were seen on patient outcome.
Polymer-derived SiOC reinforced with core-shell nanophase structure of ZrB2/ZrO2 for excellent and stable high-temperature microwave absorption (up to 900°C)
Authors: Jia Yujun , Yang Ni , Xu Shaofan , Snyder Alexander , Patrick Jason , Kumar Rajan , Zhang Dajie , Xu Chengying 
Published: October 2022

Abstract
Microwave absorbing materials for high-temperature harsh environments are highly desirable for aerodynamically heated parts and engine combustion induced hot spots of aircrafts. This study reports ceramic composites with excellent and stable high-temperature microwave absorption in air, which are made of polymer-derived SiOC reinforced with core-shell nanophase structure of ZrB2/ZrO2. The fabricated ceramic composites have a crystallized t-ZrO2 interface between ZrB2 and SiOC domains. The ceramic composites exhibit stable dielectric properties, which are relatively insensitive to temperature change from room temperature to 900oC. The return loss exceeds − 10dB, especially between 28-40GHz, at the elevated temperatures. The stable high-temperature electromagnetic (EM) absorption properties are attributed to the stable dielectric and electrical properties induced by the core-shell nanophase structure of ZrB2/ZrO2. Crystallized t-ZrO2 serve as nanoscale dielectric interfaces between ZrB2 and SiOC, which are favorable for EM wave introduction for enhancing polarization loss and absorption. Existence of t-ZrO2 interface also changes the temperature-dependent DC conductivity of ZrB2/SiOC ceramic composites when compared to that of ZrB2 and SiOC alone. Experimental results from thermomechanical, jet flow, thermal shock, and water vapor tests demonstrate that the developed ceramic composites have high stability in harsh environments, and can be used as high-temperature wide-band microwave absorbing structural materials.
Effect of nitrogen and spacing on flower yield of spider lily (Hymenocallis littoralis L.)
Authors: Ghormade Ashish S. , Haldavnekar P. C. 
Published: October 2022

Abstract
Aim: The present investigation entitled “Effect of nitrogen and spacing on flowering of spider lily (Hymenocallis littoralis L.)” was undertaken at College of Horticulture, Dr. Balasaheb Sawant Konkan Krishi Vidyapeeth, Dapoli by considering the commercial importance of spider lily under Konkan agro-climatic conditions.
Methodology: The experiment was laid out in a split plot design using four levels of nitrogen and three levels of spacing with three replications along with the common dosage of phosphorous (150 kg ha-1) and potassium (100 kg ha-1).
Results: Flower yield and yield attributing characters viz., the highest number of flower buds per plant (46.84), flower buds per ha (16.01 lakh), flower yield per plot (8.50 kg) and flower yield per ha (6.56 t ha-1) were recorded with the treatment N1 (300 kg ha-1). With regards to spacing, the highest number of flower buds per plant (36.23), flower buds per ha (19.37 lakh), flower yield per plot (9.48 kg) and flower yield per ha (7.31 t ha-1) was recorded in S3 (30 × 60 cm). However, the interaction effect of treatment combination N1S3 (300 kg N ha-1 ; 30 × 60 cm) recorded the highest number of flower buds per plant (58.52), flower buds per ha (29.49 lakh), flower yield per plot (16.06 kg) and flower yield per ha (12.39 t ha-1).
Interpretation: The observations were recorded on various flowering parameters namely number of flower buds per plant, flower buds per ha (lakh ha-1), flower yield per plot (kg plot-1) and flower yield per ha (t ha-1) and most of the parameters were differed significantly at highest levels of nitrogen and spacing.
Change in prostate volume reduction and symptomatic improvement in men treated with Rezūm convective water vapour thermal thera
Authors: Elterman Dean , Bhojani Naeem , Vannabouathong Christopher , Chughtai Bilal , Zorn Kevin 
Published: October 2022

Abstract
Background: Rezūm convective water vapour thermal therapy is a minimally invasive, office-based treatment for benign prostatic hyperplasia (BPH). While studies have demonstrated its efficacy in symptomatic improvement, its effect on objective measures such as prostate volume (PV) reduction is poorly characterized. The purpose of this study was to evaluate the change in PV and its relationship to improvement in symptom scores following Rezūm therapy.
Methods: Quality of life outcomes and PV were assessed at baseline and 12 months post-procedure. The percent change from baseline in outcomes and PV were calculated for each patient, as was the injection to baseline volume ratio. The association between the total number of vapour injections and changes in outcomes and PV were evaluated using linear regression models.
Results: A total of 49 patients (mean age = 67.8; standard deviation [SD] = 9.4) underwent the procedure between April 2019 and September 2020, with a median baseline PV of 71.5 and median number of vapour injections of 11.0. At 12 months, the median percent change in prostate volume was -34.0% (interquartile range: -49.2%, -16.7%), with 45/49 (91.8%) patients having reduced volume. Among the 45 patients with reduced volume at 12 months, every 10% increase in volume reduction was associated with a 7.5% (95% confidence interval, 1.4% to 13.6%; p=0.02) improvement in the International Prostate Symptom Score. There was no significant association between the total number of injections or injection to baseline volume ratio and change in PV.
Conclusions: In this cohort of patients treated with Rezūm convective water vapour thermal therapy for BPH, it was demonstrated that there is a correlation between greater PV reduction and greater symptomatic improvement. Additionally, this study showed no association between more injections or the ratio of injections to prostate volume changes, refuting the claim that more injections are better.
Factors Affecting Women’s Utilization of Prenatal Care Services in Gumuz Community
Authors: Almaw Dagne Yiradu 
Published: October 2022

Abstract
Underutilization of prenatal care services is one of the major hindrances which contribute for poor maternal health situations in Ethiopia. Studies with detailed investigation of factors influencing the prenatal care services especially in those remotely located communities in the country are limited. Therefore, the very purpose of this study was to explore factors affecting women in utilizing antenatal care services in Gumuz community. Moreover, making statistical measures on some identified variables to support the qualitative findings was another purpose. To attain these objectives, the study used Sequential Exploratory Mixed Method design. In-depth interview, focus group discussion, key informant interview and Survey questionnaires were used to gather data, thematic analysis was used for the qualitative data and descriptive, bivariate and multivariate analysis was used for the quantitative data. The findings showed that lack of knowledge about the services and negative attitude towards prenatal care services were identified as factors affecting women’s utilization of prenatal care services. Besides, women’s commitment to traditional ways of life, use of Gafias (local Magicians) treatments, using the local food taboo as a treatment and religious influences were identified as socio-cultural factors affecting women in using modern health care services. The results of the bivariate and multivariate analysis supported that knowledge and attitude have associations and significant effect on the service utilization. The study concludes that lack of knowledge, negative attitude, women’s commitments to traditional ways of life, Gafias treatments, local food taboo, religious influences, are the major factors affecting Gumuz women in using modern health care services. The finding of this study has important implications for further research, practice and policy and they are indicated in the paper.
Indigenous Peoples and Local Communities as partners in the sequencing of all eukaryotic life for the future of life
Authors: Cartney Ann Mc , Tsosie K. S. , Sterner B , Glass J. R. , Paez S , Geary J , Hudson Maui , Head Mitchell A. 
Published: October 2022

Abstract

The aim to sequence, catalog, and characterize the genomes of all of Earth’s eukaryotic biodiversity is the shared mission of many ongoing large scale biodiversity genomics initiatives. Reference genomes of our global flora and fauna have the potential to inform a broad range of major issues facing both biodiversity and humanity, such as the impact of climate change, the conservation of endangered species and ecosystems, public health crises, and the preservation and enhancement of ecosystem services. Biodiversity is dramatically declining: 28% of species being assessed by IUCN are threatened with extinction and recent reports suggest that a transformative change is needed to conserve and protect what remains. To provide a collective and global genomic response to the biodiversity crisis, many biodiversity genomics initiatives have come together, creating a network of networks under the Earth BioGenome Project. This network seeks to expedite the creation of an openly available, “public good” encyclopedia of high-quality eukaryotic reference genomes, in hope that by advancing our basic understanding of nature it can lead to the transformational scientific developments needed to conserve and protect global biodiversity. Key to completing this ambitious encyclopedia of reference genomes, is the ability to responsibly, ethically, legally, and equitably access and use samples from all of the eukaryotic species across the planet, including those that are under the custodianship of Indigenous Peoples and Local Communities. Here, the biodiversity genomics community is subject to the provisions codified in international, national, and local legislations but also customary community policies and protocols. We propose a framework to support biodiversity genomic researchers, projects, and initiatives in building trustworthy and sustainable partnerships with communities, providing minimum recommendations on how to access, utilize, preserve, handle, share, analyze and communicate samples, genomics data and associated Traditional Knowledge obtained from, and in partnership with, Indigenous Peoples and Local Communities across the data-lifecycle.