bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term survival in a patient with advanced non-smoking lung adenocarcinoma and no EGFR mutation after comprehensive therapy with EGFR-TKI-based therapy
Authors: Zhang Qianyu , Liu Meiling , Zhong Yunchao , Zhang Kang 
Published: January 2022

Abstract

Rationale:
This is the first known report to describe a case of advanced non-smoking lung adenocarcinoma with no epidermal growth factor receptor mutation after comprehensive epidermal growth factor receptor-tyrosine kinase inhibitor-based therapy that survived for nearly 12 years.

Patient concerns:
A 48-year-old Chinese woman that came to our hospital with a left supraclavicular mass.

Diagnosis:
The final diagnosis was left lung adenocarcinoma with left supraclavicular lymph node metastasis, cT1N3M0 IIIB (International association for the Study of lung cancer 6th version).

Interventions:
After 4 months of 4 cycles of chemotherapy, gefitinib was administered alone for 5.5 years. Local radiotherapy (40GY/20F) was administered for 1 month, and osimertinib alone was followed for 4.5 years. A combination of pemetrexed with oxaliplatin and hyperthermia at the same time was administered for 4 cycles. Toripalimab and anlotinib were administered for 3 months. Since then, the patient had been taking a double dose of icotinib herself.

Outcomes:
The patient has survived for nearly 12 years since diagnosis of lung cancer.

Lessons:
Our case is of significant importance to clinicians involved in the treatment of patients with advanced nonsmoking lung adenocarcinoma and no epidermal growth factor receptor mutations.
A 6-Year Thematic Review of Reported Incidents Associated With Cardiopulmonary Resuscitation Calls in a United Kingdom Hospital
Authors: Beed Martin , Hussain Sumera , Woodier Nick , Fletcher Cathie , Brindley Peter G. 
Published: January 2022

Background
Critical incident reporting can be applied to cardiopulmonary resuscitation (CPR) events as a means of reducing further occurrences. We hypothesized that local CPR-related events might follow patterns only seen after a long period of analysis.

Design
We reviewed 6 years of local incidents associated with cardiac arrest calls. The following search terms were used to identify actual or potential resuscitation events: “resuscitation,” “cardio-pulmonary,” “CPR,” “arrest,” “heart attack,” “DNR,” “DNAR,” “DNACPR,” “Crash,” “2222.” All identified incidents were independently reviewed and categorized, looking for identifiable patterns.

Setting
Nottingham University Hospitals is a large UK tertiary referral teaching hospital.

Results
A total of 1017 reports were identified, relating to 1069 categorizable incidents. During the same time, there were approximately 1350 cardiac arrest calls, although it should be noted that many arrest-related incidents were not associated with cardiac arrest call (e.g., failure to have the correct equipment available in the event of a cardiac arrest). Incidents could be broadly classified into 10 thematic areas: no identifiable incident (n = 189; 18%), failure to rescue (n = 133; 12%), staffing concerns (n = 134; 13%), equipment/drug concerns (n = 133; 12%), communication issues (n = 122; 10%), do-not-attempt-CPR decisions (n = 101; 9%), appropriateness of patient location or transfer (n = 96; 9%), concerns that the arrest may have been iatrogenic (n = 76; 7%), patient or staff injury (n = 43; 4%), and miscellaneous (n = 52; 5%). Specific patterns of events were seen within each category.

Conclusions
By reviewing incidents, we were able to identify patterns only noticeable over a long time frame, which may be amenable to intervention. Our findings may be generalizable to other centers or encourage others to undertake this exercise themselves.
The Compressed Sensing MP2RAGE as a Surrogate to the MPRAGE for Neuroimaging at 3 T
Authors: Trotier Aurélien J. , Dilharreguy Bixente , Anandra Serge , Corbin Nadège , Lefrançois William , Ozenne Valery , Miraux Sylvain , Ribot Emeline J. 
Published: January 2022

Objectives
The magnetization-prepared 2 rapid acquisition gradient echo (MP2RAGE) sequence provides quantitative T1 maps in addition to high-contrast morphological images. Advanced acceleration techniques such as compressed sensing (CS) allow its acquisition time to be compatible with clinical applications. To consider its routine use in future neuroimaging protocols, the repeatability of the segmented brain structures was evaluated and compared with the standard morphological sequence (magnetization-prepared rapid gradient echo [MPRAGE]). The repeatability of the T1 measurements was also assessed.

Materials and Methods
Thirteen healthy volunteers were scanned either 3 or 4 times at several days of interval, on a 3 T clinical scanner, with the 2 sequences (CS-MP2RAGE and MPRAGE), set with the same spatial resolution (0.8-mm isotropic) and scan duration (6 minutes 21 seconds). The reconstruction time of the CS-MP2RAGE outputs (including the 2 echo images, the MP2RAGE image, and the T1 map) was 3 minutes 33 seconds, using an open-source in-house algorithm implemented in the Gadgetron framework.
Both precision and variability of volume measurements obtained from CAT12 and VolBrain were assessed. The T1 accuracy and repeatability were measured on phantoms and on humans and were compared with literature.
Volumes obtained from the CS-MP2RAGE and the MPRAGE images were compared using Student t tests (P < 0.05 was considered significant).

Results
The CS-MP2RAGE acquisition provided morphological images of the same quality and higher contrasts than the standard MPRAGE images. Similar intravolunteer variabilities were obtained with the CS-MP2RAGE and the MPRAGE segmentations. In addition, high-resolution T1 maps were obtained from the CS-MP2RAGE. T1 times of white and gray matters and several deep gray nuclei are consistent with the literature and show very low variability (<1%).

Conclusions
The CS-MP2RAGE can be used in future protocols to rapidly obtain morphological images and quantitative T1 maps in 3-dimensions while maintaining high repeatability in volumetry and relaxation times.
Vortioxetine-Induced Amenorrhea: A Case Report
Authors: Işik Mesut , Kurhan Faruk , Ülkevan Tuba , Özdemir Pinar Güzel 
Published: January 2022

BackgroundVortioxetine is a novel multimodal antidepressant for the treatment of major depressive disorders and is widely used in clinical practice. Vortioxetine has a safe profile. However, there are case reports of other adverse effects in the literature. In this article, a case of amenorrhea due to vortioxetine is presented.CaseThe patient is 36 years old, married, female, and is an anesthesiologist. She applied to the psychiatric outpatient clinic with symptoms of major depression. Vortioxetine was initiated at 10 mg/d and then gradually increased to 20 mg/d. She had regular menstruation until now. However, she did not menstruate after taking vortioxetine. The patient used vortioxetine for 3 months and never had a period. Pregnancy test and other tests to investigate organic etiology were normal. Two weeks after discontinuation of vortioxetine, the patient had a menstrual period.ConclusionsFurther research is needed on the relationship and possible mechanisms between vortioxetine and amenorrhea.
Comparable human spatial memory distortions in physical, desktop virtual and immersive virtual environments
Authors: Zisch Fiona E. , Newton Coco , Coutrot Antoine , Murcia Maria , Motala Anisa , Greaves Jacob , Cothi William de , Steed Anthony , Tyler Nick , Gage Stephen A. , Spiers Hugo J. 
Published: January 2022

AbstractBoundaries define regions of space and are integral to episodic memories. The impact of boundaries on spatial memory and neural representations of space has been extensively studied in freely-moving rodents. But less is known in humans and many prior studies have employed desktop virtual reality (VR) which lacks the body-based self-motion cues of the physical world, diminishing the potentially strong input from path integration to spatial memory. We replicated a desktop-VR study testing the impact of boundaries on spatial memory (Hartley et al., 2004) in a physical room (2.4m x 2.4m, 2m tall) by having participants (N = 27) learn the location of a circular stool and then after a short delay replace it where they thought they had found it. During the delay, the wall boundaries were either expanded or contracted. We compared performance to groups of participants undergoing the same procedure in a laser-scanned replica in both desktop VR (N = 44) and freely-walking head mounted display (HMD) VR (N = 39) environments. Performance was measured as goodness of fit between the spatial distributions of group responses and seven modelled distributions that prioritised different metrics based on boundary geometry or walking paths to estimate the stool location. The best fitting model was a weighted linear combination of all the geometric spatial models, but an individual model derived from place cell firing in Hartley et al. 2004 also fit well. High levels of disorientation in all three environments prevented detailed analysis on the contribution of path integration. We found identical model fits across the three environments, though desktop VR and HMD-VR appeared more consistent in spatial distributions of group responses than the physical environment and displayed known variations in virtual depth perception. Thus, while human spatial representation appears differentially influenced by environmental boundaries, the influence is similar across virtual and physical environments. Despite differences in body-based cue availability, desktop and HMD-VR allow a good and interchangeable approximation for examining human spatial memory in small-scale physical environments.
Cue-induced cocaine craving enhances psychosocial stress and vice versa in chronic cocaine users
Authors: Kexel Ann-Kathrin , Kluwe-Schiavon Bruno , Baumgartner Markus R. , Engeli Etna J. E. , Visentini Monika , Kirschbaum Clemens , Seifritz Erich , Ditzen Beate , Soravia Leila M. , Quednow Boris B. 
Published: January 2022

AbstractThere is evidence that stress and craving contribute to the development, maintenance, and relapse in cocaine use disorder. Previous research has shown altered physiological responses to psychosocial stress as well as increased vegetative responding to substance-related cues in chronic cocaine users (CU). However, how psychosocial stress and cue-induced craving interact in relation to the physiological response of CU is largely unknown. Therefore, we investigated the interaction between acute psychosocial stress and cocaine-cue-related reactivity in 47 CU and 38 controls. Participants were randomly exposed first to a video-based cocaine-cue paradigm and second to the Trier Social Stress Test (TSST) or vice versa in a crossed and balanced design to investigate possible mutually augmenting effects of both stressors on the physiological stress response. Plasma cortisol, ACTH, and noradrenaline as well as subjective stress and craving were assessed repeatedly over the course of the experimental procedure. Growth models and discontinuous growth models were used to estimate the responses during the cocaine-cue paradigm and TSST. Overall, both groups did not differ in their endocrinological responses to the TSST but CU displayed lower ACTH levels at baseline. The TSST did not elevate craving in CU. However, if the cocaine-cue video was shown first, CU displayed an enhanced cortisol response to the subsequent TSST. Cocaine-cues robustly evoked craving in CU but no stress response, while cue-induced craving was intensified after the TSST. Taken together, CU did not show an altered acute stress response during the TSST but stress and craving together seem to have mutually augmenting effects on their stress response.
Utility of estimated pulse wave velocity for assessing vascular stiffness: comparison of methods
Authors: Möstl Stefan , Hoffmann Fabian , Hönemann Jan-Niklas , Alvero-Cruz Jose Ramon , Rittweger Jörn , Tank Jens , Jordan Jens 
Published: January 2022

AbstractAimPulse wave velocity independently predicts cardiovascular risk. Easy to use single cuff oscillometric methods are utilized in clinical practice to estimate pulse wave velocity. We applied the approach in master athletes to assess possible beneficial effects of lifelong exercise on vascular health. Furthermore, we compared single cuff measurements with a two-cuff method in another cohort.MethodsWe obtained single cuff upper arm oscillometric measurements thrice in 129 master athletes aged 35 to 86 years and estimated pulse wave velocity using the ArcSolver algorithm. We applied the same method in 24 healthy persons aged 24 to 55 years participating in a head down tilt bedrest study. In the latter group, we also obtained direct pulse wave velocity measurements using a thigh cuff.ResultsEstimated pulse velocity very highly correlated with age (R²= 0.90) in master athletes. Estimated pulse wave velocity values were located on the same regression line like values obtained in participants of the head down tilt bed rest study. The modest correlation between estimated and measured PWV (r2 0.40; p<0.05) was attenuated after adjusting for age; the mean difference between pulse wave velocity measurements was 1 m/s.ConclusionEstimated pulse wave velocity mainly reflects the entered age rather than true vascular properties and, therefore, failed detecting beneficial effects of life long exercise.FundingThe AGBRESA-Study was funded by the German Aerospace Center (DLR), the European Space Agency (ESA, contract number 4000113871/15/NL/PG) and the National Aeronautics and Space Administration (NASA, contract number 80JSC018P0078). FH received funding by the DLR and the German Federal Ministry of Economy and Technology, BMWi (50WB1816). SM, JT and JJ were supported by the Austrian Federal Ministry for Climate Action, Environment, Energy, Mobility, Innovation and Technology, BMK (SPACE4ALL Project, FFG No. 866761).
SLDP and LIPA mediate lipid droplet-plasma membrane tethering in Arabidopsis thaliana
Authors: Krawczyk Hannah Elisa , Sun Siqi , Doner Nathan M. , Yan Qiqi , Lim Magdiel , Scholz Patricia , Niemeyer Philipp , Schmitt Kerstin , Valerius Oliver , Pleskot Roman , Hillmer Stefan , Braus Gerhard H. , Wiermer Marcel , Mullen Robert T. , Ischebeck Till 
Published: January 2022

ABSTRACTMembrane contact sites (MCS) are inter-organellar connections that allow for the direct exchange of molecules, such as lipids or Ca2+ between organelles, but can also serve to tether organelles at specific locations within cells. Here we identified and characterised three proteins that form a lipid droplet (LD)-plasma membrane (PM) tethering complex in plant cells, namely LD-localised SEED LD PROTEIN (SLDP) 1 and 2 and PM-localised LD-PLASMA MEMBRANE ADAPTOR (LIPA). Using proteomics and different protein-protein interaction assays, we show that both SLDPs associate with LIPA. Disruption of either SLDP1 and 2 expression, or that of LIPA, leads to an aberrant clustering of LDs in Arabidopsis seedlings. Ectopic co-expression of one of the SLDPs with LIPA on the other hand is sufficient to reconstitute LD-PM tethering in Nicotiana tabacum pollen tubes, a cell type characterised by dynamically moving LDs in the cytosolic streaming. Further, confocal laser scanning microscopy revealed both SLDP2.1 and LIPA to be enriched at LD-PM contact sites in seedlings. These and other results suggest that SLDP and LIPA interact to form a tethering complex that anchors a subset of LDs to the PM during post-germinative seedling growth in Arabidopsis thaliana.One-sentence summarySEED LIPID DROPLET PROTEIN1 and 2 and LIPID DROPLET PLASMA MEMBRANE ADAPTOR tether lipid droplets to the plasma membrane in seedlings of Arabidopsis thaliana.
The link between HRD professionals’ social capital and career adaptability: a moderated mediation analysis of social network
Authors: Oh Jihye , Jeong Shinhee , Yoon Seung Won , Cho Daeyeon 
Published: January 2022

PurposeFrom a social capital perspective, this study aims to shed light on the link between social capital and career adaptability by focusing on how social connections and interactions shape and nurture career adaptability. Drawing on socioemotional selectivity theory, the authors further examined the critical moderating role of age on the above relationship.Design/methodology/approachSurvey responses from 208 HRD professionals were analyzed via a moderated mediation analysis.FindingsThe results showed that there is a positive relationship between social capital (network size and intimate network) and career adaptability; frequent interaction increases intimacy, in turn enhancing career adaptability; and the indirect effect of social capital on career adaptability (via intimate network) is stronger when the employee is younger.Originality/valueThe most novel theoretical contribution of this study is that the authors lend empirical support to the connection between social capital and career adaptability moderated by age. The study also contributes to understanding how core aspects of social capital are inter-related each other and have directional relationships.
Empirical investigation regarding ethical decision making: a stakeholder cross-impact analysis (SCIA)
Authors: Mehta Nikhil Kewalkrishna , Bhattacharyya Som Sekhar , Pandey Nilay 
Published: January 2022

PurposeThe purpose of this research was to study senior and middle-level executive perspectives on ethical decision-making exploring stakeholder cross-impact analysis (SCIA). Given the complexities of business today, stakeholder identification, prioritisation and complexities of reciprocal stakeholder influences have become very important. Various philosophical approaches raised questions than responses to these problems. There was a clear need to find ways through which the worldview of agents could be assimilated and understood.Design/methodology/approachThis study used the original hypothetical short case and brought in middle and senior executive reflections of Indian fast-moving consumer goods (FMCG) managers. Reflections of ten senior and 178 middle-level Indian FMCG managers were presented, exploring ethical dilemmas using short hypothetical case. These reflections have been analysed using the SCIA framework. The pairedt-test was performed to compare the reflections of senior and middle-level executives.FindingsThe study results indicated that differences emerged regarding stakeholder identification, prioritisation and reciprocal stakeholder influences between Indian middle and senior FMCG executives. Hence, this study paved a reflective space for SCIA. The findings were in line with the tenets of agents’ dilemmas depicted in agency theory.Research limitations/implicationsThis study made contribution to theory by integrating the perspective of ethical dilemma confronted by organisational decision-making units (DMUs) with respect to stakeholder influence and prioritisation. Specifically, theoretical contribution was made towards SCIA.Practical implicationsThis study would help middle and senior executives to better understand the needs and complexities of stakeholder identification, prioritisation and complexities of reciprocal stakeholder influences.Originality/valueTo the best of the authors’ knowledge, this was one of the first studies from an emerging market context country like India that applied SCIA in the FMCG sector. Organisational DMUs while facing ethical dilemma undertook stakeholder influencevis-a-visstakeholder prioritisation.
3D printing towards implementing Industry 4.0: sustainability aspects, barriers and challenges
Authors: Malik Abrar , Ul Haq Mir Irfan , Raina Ankush , Gupta Kapil 
Published: January 2022

Purpose
Environmental degradation has emerged as one of the major limitations of industrial revolution and has led to an increased focus towards developing sustainable strategies and techniques. This paper aims to highlight the sustainability aspects of three-dimensional (3D) printing technology that helps towards a better implementation of Industry 4.0. It also aims to provide a brief picture of relationships between 3D printing, Industry 4.0 and sustainability. The major goal is to facilitate the researchers, scholars, engineers and recommend further research, development and innovations in the field.

Design/methodology/approach
The various enabling factors for implementation of Industry 4.0 are discussed in detail. Some barriers to incorporation of 3D Printing, its applications areas and global market scenario are also discussed. A through literature review has been done to study the detailed relationships between 3D printing, Industry 4.0 and sustainability.

Findings
The technological benefits of 3D printing are many such as weight savings, waste minimization and energy savings. Further, the production of new 3D printable materials with improved features helps in reducing the wastage of material during the process. 3D printing if used at a large scale would help industries to implement the concept of Industry 4.0.

Originality/value
This paper focuses on discussing technological revolution under Industry 4.0 and incorporates 3D printing-type technologies that largely change the product manufacturing scenario. The interrelationships between 3D printing, Industry 4.0 and sustainability have been discussed.
Student entrepreneurship and perceptions on social norms and university environment: evidence from a developing country
Authors: Pinheiro Gabriela Trindade , Moraes Gustavo Hermínio Salati Marcondes de , Fischer Bruno Brandão 
Published: January 2022

Purpose
Social contexts and academic environments are key elements in the debate about drivers of entrepreneurial intention and behavior in tertiary students. Nonetheless, the underlying dynamics of student entrepreneurship remain elusive. This study aims to contribute to this discussion by creating an original model that addresses the perception of entrepreneurs and potential entrepreneurs regarding the relationship between social norms, the university environment of support to entrepreneurship and the perceived satisfaction about universities’ conditions to nurture entrepreneurial orientation.

Design/methodology/approach
To investigate the hypotheses, a quantitative approach has been chosen through multivariate data analysis using partial least squares structural equation modeling applied to a sample of 595 students from 66 Brazilian universities.

Findings
The results indicate that social norms affect how students perceive their university environment in terms of entrepreneurial support. In turn, students’ impressions about such environment shape their levels of satisfaction. However, in contrast with the theory of intention–action gap, differences between actual and potential entrepreneurs could not be identified.

Originality/value
The originality of the research lies in filling an entrepreneurial intention–action gap among undergraduate students, with consistent results in a developing country. Additionally, the research presents new insights for researchers, policymakers and practitioners, exploring the students’ perceived satisfaction in relation to the university environment to support entrepreneurship.