bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decline in forced vital capacity in subjects with systemic sclerosis-associated interstitial lung disease in the SENSCIS trial compared with healthy reference subjects
Authors: Maher Toby M. , Bourdin Arnaud , Volkmann Elizabeth R. , Vettori Serena , Distler Jörg H. W. , Alves Margarida , Stock Christian , Distler Oliver 
Published: July 2022

Abstract
Background
The forced vital capacity (FVC) of healthy individuals depends on their age, sex, ethnicity and height. Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is characterised by loss of FVC. We compared FVC values in the subjects with SSc-ILD in the SENSCIS trial of nintedanib versus placebo with values from hypothetical matched healthy references.

Methods
The SENSCIS trial enrolled subjects with SSc with first non-Raynaud symptom in the prior ≤ 7 years, extent of fibrotic ILD on HRCT ≥ 10%, and FVC ≥ 40% predicted. FVC at baseline and decline in FVC over 52 weeks were compared with FVC values in hypothetical healthy reference subjects matched 1:1 to the subjects in the trial for age, sex, ethnicity and height, determined using equations published by the European Respiratory Society Global Lung Function Initiative.

Results
At baseline, mean (SD) FVC was 2460 (737) mL in the nintedanib group (n = 287) compared with 3403 (787) mL in the hypothetical matched healthy references. Mean (SD) FVC was 2544 (817) mL in the placebo group (n = 286) compared with 3516 (887) mL in the hypothetical matched healthy references. Mean (SE) changes in FVC at week 52, i.e., age-related loss of lung function, in the hypothetical healthy references matched to the nintedanib and placebo groups, respectively, were − 26.3 (0.5) mL and − 25.8 (0.5) mL. The difference in the change in FVC at week 52 between the nintedanib group and the hypothetical healthy references was 26.6 mL (95% CI: 1.2, 52.0; p = 0.04). The difference in the change in FVC at week 52 between the placebo group and the hypothetical healthy references was 77.5 mL (95% CI: 51.4, 103.7; p < 0.0001).

Conclusions
Subjects with SSc-ILD in the SENSCIS trial had impaired lung function at baseline and experienced further deterioration over 52 weeks. The decline in FVC in the placebo group was four-fold greater than in a hypothetical group of matched healthy references, whereas the decline in FVC in patients who received nintedanib was two-fold greater than in hypothetical healthy references. These data highlight the clinical relevance of the slowing of FVC decline provided by nintedanib.
Trial registration Registered 5 November 2015, https://clinicaltrials.gov/ct2/show/NCT02597933.
Temperature-responsive regulation of the fermentation of hypocrellin A by Shiraia bambusicola (GDMCC 60438)
Authors: Wen Yongdi , Liao Baosheng , Yan Xiaoxiao , Wu Zhenqiang , Tian Xiaofei 
Published: July 2022

Abstract
Background
Hypocrellin A (HA) is a perylene quinone pigment with high medicinal value that is produced by Shiraia bambusicola Henn. (S. bambusicola) and Hypocrella bambusae (Berk. & Broome) Sacc. (Ascomycetes) with great potential in clinical photodynamic therapy. Submerged cultivation of S. bambusicola is a popular technique for HA production. However, there is not much research on how temperature changes lead to differential yields of HA production.

Results
The temperature regulation of submerged fermentation is an efficient approach to promote HA productivity. After a 32 °C fermentation, the HA content in the mycelia S. bambusicola (GDMCC 60438) was increased by more than three- and fivefold when compared to that at 28 °C and 26 °C, respectively. RNA sequencing (RNA-seq) analysis showed that the regulation of the expression of transcription factors and genes essential for HA biosynthesis could be induced by high temperature. Among the 496 differentially expressed genes (DEGs) explicitly expressed at 32 °C, the hub genes MH01c06g0046321 and MH01c11g0073001 in the coexpression network may affect HA biosynthesis and cytoarchitecture, respectively. Moreover, five genes, i.e., MH01c01g0006641, MH01c03g0017691, MH01c04g0029531, MH01c04g0030701 and MH01c22g0111101, potentially related to HA synthesis also exhibited significantly higher expression levels. Morphological observation showed that the autolysis inside the mycelial pellets tightly composted intertwined mycelia without apparent holes.

Conclusions
The obtained results provide an effective strategy in the submerged fermentation of S. bambusicola for improved HA production and reveal an alternative regulatory network responsive to the biosynthesis metabolism of HA in response to environmental signals.
Total laparoscopic radical antegrade modular pancreato-splenectomy with left-posterior superior mesenteric artery first-approach for distal pancreatic cancer: step-by-step technique with a surgical case report (with video)
Authors: Nguyen Thanh Khiem , Nguyen Ham Hoi , Luong Tuan Hiep , Dang Kim Khue , Le Van Duy , Trinh Hong Son , Tran Duc Dung 
Published: July 2022

Abstract
Introduction
Left-sided pancreatic cancers are uncommon but seem more aggressive than tumors of pancreatic head. Radical antegrade modular pancreato-splenectomy (RAMPS) was proved to have safe and effective advantages while comparing with standard retrograde pancreato-splenectomy (SRPS) in recent systematic literature reviews and meta-analyses. Laparoscopic SMA first-approach RAMPS was recently proceeded with optimistic perioperative outcomes.

Case presentation
Our patient is a 67-year-old female with a medical history of diabetes and hypertension, recruited because of upper left quadrant abdominal pain. She was referred for pancreato-splenectomy because of a 3-cm-sized mass in distal pancreas. We use 5 trocars and the patient placed in a Trendelenburg position. The retroperitoneum is opened at the left-posterior side of the meso-pancreato-duodenum along to the inframesocolic space, so that the anterior surface of the aorta (AO), inferior vena cave (IVC), left renal vein (LRV), left adrenal grand (LAG), and kidney are completely exposed. The inferior border of the pancreas had been dissected and separated from the superior mesenteric vein (SMV) below the pancreatic isthmus, removed the lymph nodes (LNs) groups 14v and 17. Then, dissect of LNs groups 7,8,9,11p,12 en bloc at the superior side of the pancreas. Dissection of LNs group 14p, d or SMA LNs after transecting the pancreas. The operation time was 240 min, the estimated blood loss was 200 ml. With no postoperative complications as well as no diarrhea, the patient was discharged on the POD10 uneventfully. Pathological result: pancreatic ductal adenocarcinoma with T2N1 staging and negative margin (R0).

Conclusions
This technique was safe and effective to perform precise and complete lymphadenectomy and negative posterior resection in total laparoscopic left-posterior SMA first-approach RAMPS for distal pancreatic cancer.
Indigenous knowledge system associated with the uses of insects for therapeutic or medicinal purposes in two main provinces of Burkina Faso, West Africa
Authors: Ouango Mamadou , Romba Rahim , Drabo Samuel Fogné , Ouedraogo Noufou , Gnankiné Olivier 
Published: July 2022

Abstract
Background
Some insects are harmful to humans, plants and animals, but some of them can also be a source of proteins, fats, vitamins and minerals and be of therapeutic value. The therapeutic potential requires that medicinal insects and their derived products need to be scrutinized. This study highlights the indigenous knowledge related to their use of medicinal insects in peri-urban and urban areas of Burkina Faso.

Methods
The survey was carried out among 60 traditional healers spread across two phytogeographical zones of Burkina Faso. The questionnaire focused on medicinal insects used by experienced traditional healers. Chi-square tests and principal component analysis were performed to test for significant differences regarding knowledge of how insects in phytogeographically different areas were used therapeutically in connection with different disease categories.

Results
A total of 19 species of medicinal insects belonging to 6 orders were cited in connection with treatments of at least 78 pathologies and symptoms. Most frequently mentioned was gastroenteritis. Our study showed that 48.78% of the insects and their products were associated with 46 plant species for the treatment of pathologies. In addition, honey, beeswax and nests were the most widely insect products used.

Conclusion
The current study allows us to identify medicinal insects as well as their products used in the treatment of pathologies and symptoms, suggesting the presence of a considerable diversity of therapeutically important insect species. These insects are used alone and/or with their products but often in association with medicinal plants. The results constitute a useful database for future studies of medicinal insects in central and western parts of Burkina Faso.
The association between intrapartum interventions and immediate and ongoing breastfeeding outcomes: an Australian retrospective population-based cohort study
Authors: Andrew Madison S. , Selvaratnam Roshan J. , Davies-Tuck Miranda , Howland Kim , Davey Mary-Ann 
Published: July 2022

Abstract
Background
The use of intrapartum interventions is becoming increasingly common globally. Interventions during birth, including caesarean section (CS), epidural analgesia and synthetic oxytocin infusion, can be important in optimizing obstetric care, but have the potential to impact breastfeeding. This study aimed to identify whether women who have certain intrapartum interventions have greater odds of unfavourable breastfeeding outcomes, both the immediate post-partum period and in the months after birth.

Methods
This was a population-based cohort study of singleton livebirths at ≥37 weeks’ gestation between 2010 and 2018 in Victoria, Australia using routinely-collected state-wide data from the Victorian Perinatal Data Collection (VPDC) and the Child Development Information System (CDIS). The interventions included were pre-labour CS, in-labour CS, epidural analgesia, and synthetic oxytocin infusion (augmentation and/or induction of labour). Outcomes were formula supplementation in hospital, method of last feed before hospital discharge and breastfeeding status at 3-months and 6-months. Descriptive statistics and multivariable logistic regression models adjusting for potential confounders were employed.

Results
In total, 599,191 women initiated breastfeeding. In-labour CS (aOR 1.96, 95%CI 1.93,1.99), pre-labour CS (aOR 1.75, 95%CI 1.72,1.77), epidural analgesia (aOR 1.45, 95%CI 1.43,1.47) and synthetic oxytocin infusion (aOR 1.24, 95%CI 1.22,1.26) increased the odds of formula supplementation in hospital. Long-term breastfeeding data was available for 105,599 infants. In-labour CS (aOR 0.79, 95%CI 0.76,0.83), pre-labour CS (aOR 0.73, 95%CI 0.71,0.76), epidural analgesia (aOR 0.77, 95%CI 0.75,0.80) and synthetic oxytocin infusion (aOR 0.89, 95%CI 0.86–0.92) decreased the odds of exclusive breastfeeding at 3-months post-partum, which was similar at 6-months. There was a dose-response effect between number of interventions received and odds of each unfavourable breastfeeding outcome.

Conclusion
Common intrapartum interventions are associated with less favourable breastfeeding outcomes, both in hospital and in the months after birth. This confirms the importance of only undertaking interventions when necessary. When interventions are used intrapartum, an assessment and identification of women at increased risk of early discontinuation of breastfeeding has to be performed. Targeted breastfeeding support for women who have intrapartum interventions, when they wish to breastfeed, is important.
Longitudinal associations of DNA methylation and sleep in children: a meta-analysis
Authors: Sammallahti Sara , Koopman-Verhoeff M. Elisabeth , Binter Anne-Claire , Mulder Rosa H. , Cabré-Riera Alba , Kvist Tuomas , Malmberg Anni L. K. , Pesce Giancarlo , Plancoulaine Sabine , Heiss Jonathan A. , Rifas-Shiman Sheryl L. , Röder Stefan W. , Starling Anne P. , Wilson Rory , Guerlich Kathrin , Haftorn Kristine L. , Page Christian M. , Luik Annemarie I. , Tiemeier Henning , Felix Janine F. , Raikkonen Katri , Lahti Jari , Relton Caroline L. , Sharp Gemma C. , Waldenberger Melanie , Grote Veit , Heude Barbara , Annesi-Maesano Isabella , Hivert Marie-France , Zenclussen Ana C. , Herberth Gunda , Dabelea Dana , Grazuleviciene Regina , Vafeiadi Marina , Håberg Siri E. , London Stephanie J. , Guxens Mònica , Richmond Rebecca C. , Cecil Charlotte A. M. 
Published: July 2022

AbstractBackgroundSleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to underlie variation in sleep or may be an early-life marker of sleep disturbances. We examined if DNA methylation at birth or in school age is associated with parent-reported and actigraphy-estimated sleep outcomes in children.MethodsWe meta-analysed epigenome-wide association study results. DNA methylation was measured from cord blood at birth in 11 cohorts and from peripheral blood in children (4–13 years) in 8 cohorts. Outcomes included parent-reported sleep duration, sleep initiation and fragmentation problems, and actigraphy-estimated sleep duration, sleep onset latency and wake-after-sleep-onset duration.ResultsWe found no associations between DNA methylation at birth and parent-reported sleep duration (n = 3658), initiation problems (n = 2504), or fragmentation (n = 1681) (pvalues above cut-off 4.0 × 10–8). Lower methylation atcg24815001andcg02753354at birth was associated with longer actigraphy-estimated sleep duration (p = 3.31 × 10–8,n = 577) and sleep onset latency (p = 8.8 × 10–9,n = 580), respectively. DNA methylation in childhood was not cross-sectionally associated with any sleep outcomes (n = 716–2539).ConclusionDNA methylation, at birth or in childhood, was not associated with parent-reported sleep. Associations observed with objectively measured sleep outcomes could be studied further if additional data sets become available.
Advancing equity through strengthening research on health and well-being of Asian American, Native Hawaiian, and Pacific Islander
Authors: Xi Dan , Lei Ming , Liu Paul , Vemuri Ramesh , Ye Yihong 
Published: July 2022

AbstractThe National Institutes of Health’s Asian American, Native Hawaiian and Pacific Islander Health Scientific Interest Group (NIH AANHPI-HSIG) provides a viewpoint on developing approaches to enhance research on health and wellbeing for Asian American, Native Hawaiian, and Pacific Islander ethnic populations, in order to advance racial equity amongst such populations.
Research progress on world natural heritage conservation: its buffer zones and the implications
Authors: Zhang Juan , Xiong Kangning , Liu Zhaojun , He Lixiang 
Published: July 2022

Abstract
In recent decades, World Heritage Sites (WHSs) have faced external severe threats in the context of global economisation and urbanisation. The buffer zone as a conservation layer and management tool for WHSs has attracted increasing scholarly attention and debate. However, there is limited understanding of buffer zones’ social and ecological role in the conservation of World Natural Heritage Sites (WNHSs) and a lack of summary of research progress on buffer zones. To fill this gap, this study systematically reviews the existing knowledge and research gaps on buffer zones in WNHSs worldwide. We used a systematic literature review framework of Search, Assessment, Synthesis and Analysis (SALSA) through the WoS and CNKI databases to obtain 188 articles that met the inclusion criteria.
The aim was to analyze the temporal and regional distribution of publications, types of studies, main processes and landmark achievements, gaps, and implications for future research. Results indicated that: (1) there is an overall upward trend in the number of publications, reaching a maximum in 2020, with the most published in Asia and Europe. The research process presents two main categories of ecologically and socially oriented. (2) The main landmark achievements include theoretical research, technology and methods, model construction, benefit monitoring and evaluation, experimental demonstration, etc. Among them, theoretical research is the most numerous (58.51%). (3) On this basis, 8 key scientific issues are summarised. Reviewing the research progress and summarising the critical scientific issues will provide practical guidance for the effective implementation of the role of buffer zones in global WNH conservation, especially for karst WNHSs with fragile ecological environments. (4) The future of Karst WNH conservation should be based on the effect of human-land relationship in promoting heritage protection. Examining the institutional factors of ecological problems and the management of degraded ecosystems from a socio-economic perspective. The purpose is to seek a socio-ecological system that is composed of the social, economic, ecological and cultural dimensions of the buffer zone. Focus on the coupling between eco-industrial development and WNH conservation, and strengthen buffer zone communities’ adaptive and collaborative management. Explore techniques and methods of conservation adapted to the characteristics of the fragile ecosystem of karst itself, and conduct experimental demonstrations.
The Accumulation of Economic Disadvantage: The Influence of Childbirth and Divorce on the Income and Poverty Risk of Single Mothers
Authors: Harkness Susan 
Published: July 2022

Abstract
This study examines how motherhood earnings penalties in combination with the cost of partner absence affect single mothers' economic well-being. Using longitudinal data from the Panel Study of Income Dynamics for 1990–2015 and fixed-effects models with individual-specific slopes reveals that when needs are controlled for, the transition to parenthood is as strongly linked to reduced family income as partner absence is. I consider different routes to single motherhood and predict that income penalties will differ for women entering single motherhood at a first child's birth and for women who were married at first childbirth but later separated. I show that previously married mothers face larger income penalties than those who were single at first childbirth because they see larger declines in their earnings following childbirth. The results illustrate how marriage and parenthood, alongside partner absence, shape the economic prospects of single-mother families. These findings highlight the importance of reducing gender inequalities in the labor market to improve single mothers' economic well-being.
Impact on the incidence of suspected physical abuse in children under 24 months of age during a global pandemic: A multi-centre Irish regional retrospective cross-sectional analysis
Authors: McDonnell Caoimhe , Courtney Michael , Barrett Michael , McDonnell Thérèse , Persaud Thara , Twomey Eilish , Harty Sinead , Byrne Angela T 
Published: July 2022

Objectives The advent of the COVID-19 pandemic has resulted in periods of nationwide restrictions in Ireland including school and workplace closures. The authors hypothesised that this disruption to society may have led to a change in patterns of suspected physical abuse (SPA) presentations to the paediatric emergency department (ED), whilst ED attendance fell dramatically during the period. We reviewed data to determine whether there was an increase in presentations of SPA during periods of social restrictions. Methods The National Integrated Medical Imaging Service was searched for all skeletal survey examinations performed between the dates of the 1 March 2016 and 28 Feb 2021 for studies performed in cases of SPA. Electronic records of attendance were extracted from the emergency department administrative system at the three paediatric emergency departments which serve the 400,000 children regionally. The data were reviewed to determine if SPA presentations increased during restriction periods. Results 311 individual paediatric patients aged 24 months and under were referred for SPA skeletal survey during the study period. During the 2020/2021 period, 60 children were referred for SPA workup and there was no statistically significant difference between monthly referrals (mean 5, sd 2.92) in this period and matched periods over the preceding 4 years (mean 5.23, sd 2.69). Conclusions The incidence of SPA did not increase during the period of national restrictions during the COVID-19 pandemic. Advances in knowledge Periods of social restrictions taken to protect the public health during a pandemic do not result in short term increases in suspected physical abuse in the regional paediatric population.
Investigation Study of Ultrasound Practitioners’ Awareness about Artefacts of Hepatobiliary Imaging in Almadinah Almunawwarah
Authors: Alsaedi Hassan Ibrahim , Krsoom Anas Malik , Alshoabi Sultan Abdulwadoud , Alsharif Walaa M. 
Published: July 2022

Objectives: To investigate the knowledge and awareness of ultrasound practitioners’ concerning ultrasound artefacts in evaluating the hepatobiliary system.
Methods: This electronic questionnaire-based comparative study involved the ultrasound practitioners’ who work in the radiology departments in Almadinah Almunawwarah governmental hospitals during the period from 1 November 2020 to 30 April 2021. Spearman’s rho correlation test was used to correlate between knowledge and job, academic qualification, and years of experience. A T-test and cross tabulation test were done to compare the knowledge about artefacts among radiologists and radiologic technologists.
Results: This study involved 94 participants distributed as 22 (23.4%) radiologists and 72 (76.6%) radiologic technologists. The results shows that 85%, 71%, 73%, 69%, 54% and 53% of the participants assigned the acoustic shadowing, acoustic enhancement, ring down, side lobe, reverberation and mirror artefacts, as artefacts respectively. However, 68%, 53%, 19%, 19%, 18%, and 40% of the participants gave correct final diagnosis of acoustic shadowing, acoustic enhancement, ring down, side lobes, reverberation, and mirror artifacts, respectively. Spearman’s rho correlation test shows significant correlation between participants with more than three years experience and knowledge related mirror artefacts (r=0.328, p=0.001). It shows significant correlation between radiologists with knowledge related mirror artefacts (r=0.367, p<0.001). A significant correlation was found between highly qualified participants and knowledge related mirror artefacts (r=0.336, p=0.001) and side lobe artefacts (r=0.237, p=0.008).
Conclusion: The questionnaire-based comparative study of knowledge about artefacts of hepatobiliary ultrasound imaging reveals a high level of Ultrasound practitioners’ knowledge in differentiating artefacts from pathology with a high level of knowledge in identifying hepatobiliary acoustic shadowing and acoustic enhancement artefacts. However, insufficient knowledge was noted in identifying mirror, side lobe, reverberation and ring down artefacts. A direct link was found between academic qualification, years of experience and practioners’ knowledge among.
doi: https://doi.org/10.12669/pjms.38.6.5084
How to cite this:Alsaedi HI, Krsoom AM, Alshoabi SA, Alsharif WM. Investigation Study of Ultrasound Practitioners’ Awareness about Artefacts of Hepatobiliary Imaging in Almadinah Almunawwarah. Pak J Med Sci. 2022;38(6):1526-1533. doi: https://doi.org/10.12669/pjms.38.6.5084
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.