bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between autoantibody types and salivary gland hypofunction in patients with primary Sjögren's syndrome
Authors: Kim Bok Eum , Kwon Jeong‐Seung , Choi Jong Hoon , Park Pil Gyu , Ahn Hyung‐Joon 
Published: October 2022

AbstractBackgroundThis study analyzed the association between autoantibody types and salivary gland hypofunction in patients with primary Sjögren's syndrome (pSS).MethodsA retrospective analysis was performed on patients who visited the Department of Orofacial Pain and Oral Medicine at Yonsei University Dental Hospital from January 1, 2010 to May 31, 2021, and who were diagnosed with pSS. Out of 191 patients who fulfilled the 2016 American College of Rheumatology/European League Against Rheumatism classification criteria, 50 were positive for both anti‐Ro/SSA and anti‐La/SSB, whereas 97 had anti‐Ro/SSA but not anti‐La/SSB antibodies. Forty‐four patients for whom neither anti‐Ro/SSA nor anti‐La/SSB antibodies were found were diagnosed with Sjögren's syndrome by minor salivary gland biopsy.ResultsThe anti‐Ro/SSA antibody‐positive group showed higher rheumatoid factor (RF) levels than the anti‐Ro/SSA antibody‐negative group. The anti‐La/SSB antibody‐positive group showed lower unstimulated whole saliva (UWS), stimulated whole saliva (SWS), higher erythrocyte sedimentation rate and RF level than the anti‐La/SSB antibody‐negative group. In addition, the group with both anti‐Ro/SSA and anti‐La/SSB antibodies showed lower UWS than the group with only anti‐Ro/SSA antibodies. However, there were no significant differences in UWS or SWS after taking pilocarpine, and C‐reactive protein.ConclusionsUWS and SWS were lower when a patient was positive for anti‐La/SSB, showing that anti‐La/SSB is more likely to be involved in salivary gland hypofunction than anti‐Ro/SSA in patients with pSS. Therefore, performing laboratory tests, including anti‐La/SSB, helps predict the prognosis of salivary gland function in patients with suspected pSS.
Hepatology in space: Effects of spaceflight and simulated microgravity on the liver
Authors: Vinken Mathieu 
Published: October 2022

AbstractMicrogravity as experienced during spaceflight affects a number of physiological processes in various organs. However, effects on the liver have yet been poorly documented. Nevertheless, the liver is a metabolically highly active organ involved in carbohydrate metabolism, lipid metabolism and xenobiotic biotransformation. The present paper provides an overview of the effects of microgravity on the liver observed in experimental animals during actual spaceflight and upon simulation of microgravity on Earth. These include (i) induction of liver injury and inflammation associated with apoptosis and oxidative stress, (ii) changes in liver carbohydrate metabolism resulting in the onset of a diabetogenic phenotype, (iii) modifications in hepatic lipid metabolism leading to early non‐alcoholic fatty liver disease and (iv) alterations of the hepatic xenobiotic biotransformation machinery. Although most of these observations remain to be fully validated in humans, appropriate measures to counteract liver pathogenesis should be considered, especially in view of long‐term space missions.
Quest for the Australasian impact crater: Failings of the candidate location at the Bolaven Plateau, Southern Laos
Authors: Mizera Jiří 
Published: October 2022

AbstractThe quest for the parent impact structure for Australasian tektites (AAT) has remained without solution for almost a century. The present paper doubts the plausibility of the recently proposed location of the impact site at the Bolaven volcanic field in Southern Laos by showing problems with most of the presented lines of evidence. The geochemical incompatibility of the AAT composition with a mixture of weathered basalts and Mesozoic sandstones that were proposed as source materials of AAT is demonstrated by a two‐component mixing calculation for major element oxides and the Nd‐Sr isotopic system. Deficiency of the basaltic component as a source of Ni, Co, Cr, and 10Be in AAT and inconsistency with trends observed for O and Pb isotopes are shown. The size of the putative crater, conclusiveness of a gravity anomaly identification, signs of complete crater burial by postimpact lava flows, and identification of proximal ejecta blanket are doubted. Remarks on the shortcomings of the current consensus location of an impact site for AAT in Indochina are presented.
Electrical conductivity through π–π stacking in a two‐dimensional porous gallium catecholate metal–organic framework
Authors: Skorupskii Grigorii , Chanteux Géraldine , Le Khoa N. , Stassen Ivo , Hendon Christopher H. , Dincă Mircea 
Published: October 2022

AbstractMetal–organic frameworks (MOFs) are hybrid materials known for their nanoscale pores, which give them high surface areas but generally lead to poor electrical conductivity. Recently, MOFs with high electrical conductivity were established as promising materials for a variety of applications in energy storage and catalysis. Many recent reports investigating the fundamentals of charge transport in these materials focus on the role of the organic ligands. Less consideration, however, is given to the metal ion forming the MOF, which is almost exclusively a late first‐row transition metal. Here, we report a moderately conductive porous MOF based on trivalent gallium and 2,3,6,7,10,11‐hexahydroxytriphenylene. Gallium, a metal that has not been featured in electrically conductive MOFs so far, has a closed‐shell electronic configuration and is present in its trivalent state—in contrast to most conductive MOFs, which are formed by open‐shell, divalent transition metals. Our material, made without using any harmful solvents, displays conductivities on the level of 3 mS/cm and a surface area of 196 m2/g, comparable to transition metal analogs.
Withdrawal: A key consideration in evaluating whether highly processed foods are addictive
Authors: Parnarouskis Lindsey , Leventhal Adam M. , Ferguson Stuart G. , Gearhardt Ashley N. 
Published: October 2022

SummaryResearchers are currently debating whether theories of addiction explain compulsive overeating of highly processed (HP) foods (i.e., industrially created foods high in refined carbohydrates and/or fat), which contributes to obesity and diet‐related disease. A subset of individuals consumes HP foods with behavioral phenotypes that mirror substance use disorders. Withdrawal, the emergence of aversive physical and psychological symptoms upon reduction or cessation of substance use, is a core component of addiction that was central to historical debates about other substances' addictive potential (e.g., nicotine and cocaine). However, no one has systematically considered evidence for whether HP foods cause withdrawal, which represents a key knowledge gap regarding the utility of addiction models for understanding compulsive overeating. Thus, we reviewed evidence for whether animals and humans exhibit withdrawal when reducing or eliminating HP food intake. Controlled experimental evidence indicates animals experience HP food withdrawal marked by neural reward changes and behaviors consistent with withdrawal from other addictive substances. In humans, preliminary evidence supports subjective withdrawal‐like experiences. However, most current human research is limited to retrospective recall. Further experimental research is needed to evaluate this construct. We outline future research directions to investigate HP food withdrawal in humans and consider potential clinical implications.
The oil price uncertainty effect on stock returns of the Indian renewable energy firms under different market conditions
Authors: Mishra Lalatendu , Acharya Rajesh H. 
Published: October 2022

AbstractThis study investigates the oil price uncertainty effect on stock return of the Indian renewable energy firms under different market conditions. We use the Oil Volatility Index (OVX) as a proxy of oil price uncertainty. All renewable energy companies listed on the National Stock Exchange of India are considered. Monthly data are analysed from January 2009 to December 2019 using panel quantile regression. In the whole sample of the renewable energy firms, we find that the impact of oil price volatility on stock return is negative only in extreme market conditions. In subgroups of renewable energy firms, oil price volatility has negative coefficients in most quantiles. The oil price volatility change is decomposed into positive and negative changes to investigate the asymmetric effect. In subgroups of renewable energy firms' analysis, most of the asymmetric effects of oil price volatility are seen in the bearish market condition. The policymakers can use the findings to formulate policies as per the oil price volatility movement to ensure the growth of the renewable energy sector. Investors and portfolio managers can make appropriate strategies based on oil price volatility to maximise the investment return across market conditions.
Genome‐wide characterization of homeodomain‐leucine zipper genes reveals RsHDZ17 enhances the heat tolerance in radish (Raphanus sativus L.)
Authors: Wang Kai , Xu Liang , Wang Yan , Ying Jiali , Li Jingxue , Dong Junhui , Li Cui , Zhang Xiaoli , Liu Liwang 
Published: October 2022

AbstractHomeodomain‐leucine zipper (HD‐Zip) transcription factors are involved in various biological processes of plant growth, development, and abiotic stress response. However, how they regulate heat stress (HS) response remains largely unclear in plants. In this study, a total of 83 RsHD‐Zip genes were firstly identified from the genome of Raphanus sativus. RNA‐Seq, RT‐qPCR and promoter activity assays revealed that RsHDZ17 from HD‐Zip Class I was highly expressed under heat, salt, and Cd stresses. RsHDZ17 is a nuclear protein with transcriptional activity at the C‐terminus. Ectopic overexpression (OE) of RsHDZ17 in Arabidopsis thaliana enhanced the HS tolerance by improving the survival rate, photosynthesis capacity, and scavenging for reactive oxygen species (ROS). In addition, transient OE of RsHDZ17 in radish cotyledons impeded cell injury and augmented ROS scavenging under HS. Moreover, yeast one‐hybrid, dual‐luciferase assay, and electrophoretic mobility shift assay revealed that RsHDZ17 could bind to the promoter of HSFA1e. Collectively, these pieces of evidence demonstrate that RsHDZ17 could play a positive role in thermotolerance, partially through up‐regulation of the expression of HSFA1e in plants. These results provide novel insights into the role of HD‐Zips in radish and facilitate genetical engineering and development of heat‐tolerant radish in breeding programs.
Illegal drugs and periodontal conditions
Authors: Quaranta Alessandro , D'Isidoro Orlando , Piattelli Adriano , Hui Wang Lai , Perrotti Vittoria 
Published: October 2022

AbstractIn recent years, the practice of dentistry and periodontology has become complicated by several risk factors, including the treatment of an increasing number of patients with substance use disorder. This review presents an update in the current literature of the impact of illegal drug use on periodontal conditions and their possible effect as risk factors or indicators. The main illegal drugs that may have an impact on periodontal health and conditions are described, including their effect, medical manifestations, risks, and the overall effect on oral health and on the periodontium. Where available, data from epidemiologic studies are analyzed and summarized. The clinical management of periodontal patients using illegal drugs is reported in a comprehensive approach inclusive of the detection of illicit drug users, screening, interviewing and counseling, the referral to treatment, and the dental and periodontal management. With regard to the impact of illegal substance use on periodontal conditions, there is moderate evidence that regular long‐term use of cannabis is a risk factor for periodontal disease, manifesting as a loss of periodontal attachment, deep pockets, recessions, and gingival enlargements. Limited evidence also shows that the use of cocaine can cause a series of gingival conditions that mostly presents as chemical induced‐traumatic lesions (application of cocaine on the gingiva) or necrotizing ulcerative lesions. There is a scarcity of data regarding the impact of other drug use on periodontal health. There is evidence to suggest that regular long‐term use of cannabis is a risk factor for periodontal disease and that the use of cocaine can cause a series of periodontal conditions. The dental treatment of subjects that use illegal substances is becoming more common in the daily clinical practice of periodontists and other dental clinicians. When the clinicians encounter such patients, it is essential to manage their addiction properly taking into consideration the impact of it on comprehensive dental treatment. Further studies and clinical observations are required to obtain sound and definitive information.
Orienting versus inhibition: The theory behind the ocular‐based Concealed Information Test
Authors: klein Selle Nathalie , Suchotzki Kristina , Pertzov Yoni , Gamer Matthias 
Published: October 2022

AbstractWhen trying to conceal one's knowledge, various ocular changes occur. However, which cognitive mechanisms drive these changes? Do orienting or inhibition—two processes previously associated with autonomic changes—play a role? To answer this question, we used a Concealed Information Test (CIT) in which participants were either motivated to conceal (orienting + inhibition) or reveal (orienting only) their knowledge. While pupil size increased in both motivational conditions, the fixation and blink CIT effects were confined to the conceal condition. These results were mirrored in autonomic changes, with skin conductance increasing in both conditions while heart rate decreased solely under motivation to conceal. Thus, different cognitive mechanisms seem to drive ocular responses. Pupil size appears to be linked to the orienting of attention (akin to skin conductance changes), while fixations and blinks rather seem to reflect arousal inhibition (comparable to heart rate changes). This knowledge strengthens CIT theory and illuminates the relationship between ocular and autonomic activity.
Is wealth found in the soil or in the brain? Investing in farm people in Malawi
Authors: Mkondiwa Maxwell 
Published: October 2022

AbstractShould a typical developing country invest more in agriculture or education? At what stage of development is it optimal to invest more in each of these sectors? These are important questions that governments of developing countries grapple with when designing investment plans. In this paper, I propose a soil–human capital conceptual framework of development and use it to explain estimates of agricultural returns to schooling in Malawi. I use panel survey data for Malawi and rely on the exogenous education policy changes and spatial variation in access to schooling to identify effects of schooling on agricultural incomes. In addition, I correct for selection into income activities within a panel data and instrumental variables estimation framework. I find annual agricultural returns to schooling in Malawi of 3%–4% after correcting for selection and unobserved heterogeneity and 7% in the uncorrected specifications. I also find consistently higher returns to schooling in the nonagricultural sector for those not living in the village of birth and higher returns in the agricultural sector for those living in the village of birth. Given the size of the farm sector, wealth in Malawi is still in the soil, but that future growth in wealth depends on human capital investments.
Big Data and Official Statistics†
Authors: Abraham Katharine G. 
Published: October 2022

AbstractThe infrastructure and methods for developed countries' economic statistics, largely established in the mid‐20th century, rest almost entirely on survey and administrative data. The increasing difficulty of obtaining survey responses threatens the sustainability of this model. Meanwhile, users of economic data are demanding ever more timely and granular information. “Big data” originally created for other purposes offer the promise of new approaches to the compilation of economic data. Drawing primarily on the U.S. experience, the paper considers the challenges to incorporating big data into the ongoing production of official economic statistics and provides examples of progress towards that goal to date. Beyond their value for the routine production of a standard set of official statistics, new sources of data create opportunities to respond more nimbly to emerging needs for information. The concluding section of the paper argues that national statistical offices should expand their mission to seize these opportunities.
Level of adherence to anti‐tubercular treatment among drug‐sensitive tuberculosis patients on a newly introduced daily dose regimen in South India: A cross‐sectional study
Authors: Thamineni Rajavardhana , Peraman Ramalingam , Chenniah Jayakumar , Meka Geethavani , Munagala Ashok Kumar , Mahalingam Vijayakumar Thangavel , Ganesan Rajanandh Muhasaparur 
Published: October 2022

AbstractIntroductionTuberculosis (TB) patients on the National Tuberculosis Elimination Program (NTEP) treatment protocol receive daily doses without health professional‐supervised drug intake as during the previous directly observed treatment short‐course (DOTS) regimen. We aimed to measure the level of adherence to anti‐tubercular treatment (ATT) and the reasons for non‐adherence among drug‐sensitive TB patients on a daily‐dose regimen in South India.MethodsA cross‐sectional study was conducted among TB patients who received ATT as part of the standard treatment protocol in NTEP. Patients were interviewed to capture their understanding of TB, adherence, and the reason for non‐adherence to ATT using validated instruments. Urine drug metabolite testing was performed using the high‐performance liquid chromatography (HPLC) technique to confirm adherence.ResultsA total of 488 patients were recruited for the study. 64.8% of patients had ‘good knowledge’ about TB and ATT. According to the subjective report, 63.7% of patients were adherent, but urine drug metabolite testing revealed 53.4% adherence. A statistically significant difference (p < 0.05) exists between subjective and objective adherence measures. Patient‐reported reasons for non‐adherence were side effects of ATT (18.6%), loss of daily wages (15.0%), and forgetfulness (10.0%), among others.ConclusionsNearly half of the patients were non‐adherent to the daily dosing regimen. Adherence as reported by the patients is unreliable, and urine testing could be used in routine care to assess adherence.Clinical Trial Registration and NumberCTRI/2020/04/024941.
HIV incidence and related risks among gay, bisexual, and other men who have sex with men in Montreal, Toronto, and Vancouver: Informing blood donor selection criteria in Canada
Authors: Lambert Gilles , Cox Joseph , Fourmigue Alain , Dvorakova Milada , Apelian Herak , Moodie Erica E. M. , Grace Daniel , Skakoon‐Sparling Shayna , Moore David M. , Lachowsky Nathan , Jollimore Jody , Lal Allan , Parlette Abbie , Hart Trevor A. ,   the Engage Study Team
Published: October 2022

AbstractBackgroundAn individualized behavior‐based selection approach has potential to allow for a more equitable blood donor eligibility process. We collected biological and behavioral data from urban gay, bisexual, and other men who have sex with men (GBM) to inform the use of this approach in Canada.Study design and methodsEngage is a closed prospective cohort of sexually active GBM, aged 16+ years, recruited via respondent‐driven‐sampling (RDS) in Montreal, Toronto, and Vancouver, Canada. Participants completed a questionnaire on behaviors (past 6 months) and tested for HIV and sexually transmitted and blood‐borne infections at each visit. Rate ratios for HIV infection and predictive values for blood donation eligibility criteria were estimated by RDS‐adjusted Poisson regression.ResultsData on 2008 (study visits 2017‐02 to 2021‐08) HIV‐negative participants were used. The HIV incidence rate for the three cities was 0.4|100 person‐years [95%CI:0.3, 0.6]. HIV seroconversion was associated with age <30 years: adjusted rate ratio (aRR) 9.1 [95%CI:3.2, 26.2], 6–10 and >10 anal sex partners versus 1–6 aRR: 5.3 [2.1,13.5] and 8.4 [3.4, 20.9], and use of crystal methamphetamine during sex: 4.2 [1.5, 11.6]. Applying the combined selection criteria: drug injection, ≥2 anal sex partners, and a new anal sex partner, detected all participants who seroconverted (100% sensitivity, 100% negative predictive value), and would defer 63% of study participants from donating.ConclusionUsing three screening questions regarding drug injection and sexual behaviors in the past 6 months would correctly identify potential GBM donors at high risk of having recently contracted HIV. Doing so would reduce the proportion of deferred sexually active GBM by one‐third.
Closed system processing variables affect post‐thaw quality characteristics of cryopreserved red cell concentrates
Authors: Howell Anita , Turner Tracey R. , Hansen Adele , Lautner Larissa J. , Yi Qilong , Acker Jason P. 
Published: October 2022

AbstractBackgroundDifferences in manufacturing conditions using the Haemonetics ACP 215 cell processor result in cryopreserved red cell concentrates (RCCs) of varying quality. This work studied the effect of processing method, additive solution, and storage duration on RCC quality to identify an optimal protocol for the manufacture of cryopreserved RCCs.Materials and methodsRCCs were pooled‐and‐split and stored for 7, 14, or 21 days before cryopreservation. Units were glycerolized with the ACP 215 using a single or double centrifugation method. After thawing, the RCCs were deglycerolized, suspended in AS‐3, SAGM, ESOL, or SOLX/AS‐7, and stored for 0, 3, 7, 14, or 21 days before quality testing. Quality assessments included hemoglobin content, hematocrit, hemolysis, adenosine triphosphate (ATP), supernatant potassium, and mean cell volume.ResultsBoth glycerolization methods produced RCCs that met regulatory standards for blood quality. Dual centrifugation resulted in higher hemoglobin content, fewer processing alerts, and a shorter deglycerolization time than single centrifugation processing. Units processed with AS‐3 and ESOL met regulatory standards when stored for up to 21 days pre‐cryopreservation and 21 days post‐deglycerolization. However, ESOL demonstrated superior maintenance of ATP over RBCs in AS‐3. Some RCCs suspended in SAGM and SOLX exceeded acceptable hemolysis values after 7 days of post‐deglycerolization storage regardless of pre‐processing storage length.ConclusionsWhen manufacturing cryopreserved RCCs using the ACP 215, dual centrifugation processing with AS‐3 or ESOL additive solutions is preferred, with storage periods of up to 21 days both pre‐processing and post‐deglycerolization.