bluuebunny/crossref_metadata_2025_split huggingface dataset:
In-situ Field Gamma Spectrometry in a Radionuclide Air Sampler
Authors: Lebel Luke , Barlow Kyle , Boulianne Diana , Clouthier Tony 
Published: July 2022

Abstract
The work being presented is on the development of a system to measure the speciation of airborne radionuclide emissions from the environment during a nuclear emergency. On-site air sampling measurements that were conducted during the Fukushima Daiichi accident were limited because field teams had to be sent out to run the sampling systems and retrieve the filters for gamma spectrometry analysis in a separate laboratory. The start of air sampling was delayed, and it was impossible for emergency responders to use the information about the airborne radionuclide composition in a timely way. The goal of the current study is to develop a system that could provide live, near real-time information about the concentrations of different radionuclides in the air without having to rely on human intervention. The development of the prototype in the current work is largely being enabled by Cd-Zn-Te spectrometers, which provide reasonably high-resolution spectrometry given that it is a room temperature sensor, and allow the measurements to be conducted in the field. A custom filter cartridge has been designed to hold a pair of aerosol and iodine filters in place while keeping the gamma spectrometers as close as possible in order to obtain high count rate efficiencies. A single cartridge holds both filters and has an internal flow channel directing the air flow between them. The cartridge design also facilitates replacing the filters as the accumulated radioactivity on the filters becomes too high. An automation system can move a filter cartridge from the fresh cartridge storage bank to the sampling location (filtration and gamma spectrometry) and return the used filter cartridge to the used cartridge storage bank. The radionuclide air sampling system prototype has been designed and constructed. It has been tested with fixed sources located on the respective aerosol and iodine filters. The real-time data capture aspects of the system were also demonstrated with a live 131I capture experiment. The projected performance of the system during a reactor accident was also simulated, emulating the characteristic detector efficiencies and projecting how the airborne concentrations could be reconstructed. The study has designed and constructed a radionuclide air sampler that could be used for measuring airborne radioactivity in emissions from a nuclear accident. Because the gamma spectrometry measurements are done in situ with good resolution and the system is automated, it would allow data to be transmitted back to an emergency operations center immediately rather than having to wait for additional laboratory analysis.
Nuclear Radiation Knowledge and Anxiety Levels among Residents around a Nuclear Power Plant in Liaoning Province, China
Authors: Sun Lu , Qiao Baojun , Chen Zhongxing , Yao Shuang , Liu Baochen , Li Di , Zhang Zhuo , Cui Yong 
Published: July 2022

Abstract
Awareness of radiation-related knowledge (RRK) and nuclear energy-related knowledge (NERK) among residents around a nuclear power plant (NPP), as well as their concerns about a NPP, were investigated. A face-to-face survey was conducted among 1,775 residents within 30 km around the NPP in Liaoning Province, China. A single-item Likert scale, Spearman’s/Pearson’s correlation coefficients, Student’s t-test, ANOVA, and multiple-linear regression analysis were employed. Awareness of RRK and NERK among residents around the NPP was 27.7% and 36.6%, respectively. The anxiety level of respondents was negatively corelated with the distance from their residence to the NPP and age. Also, 55.6% of respondents thought that the publicity about nuclear energy/NPPs was insufficient, and 82.7% of respondents wanted to know relevant information about NPPs. Awareness of RRK and NERK among residents around the NPP was relatively low, which was related to education, occupation, and income. The anxiety level among residents was related to distance and age. The public was eager to know about RRK and NERK. These findings indicate that the publicity and education of RRK and NERK among residents around the NPP should be strengthened.
Gene Co-Expression Network Analysis Identifies Hubs in Hepatitis B Virus-Associated Hepatocellular Carcinoma
Authors: Wang Shen-Yung , Huang Yen-Hua , Liang Yuh-Jin , Wu Jaw-Ching 
Published: July 2022

Background:
Hepatocellular carcinoma (HCC) is among the leading causes of cancer-related death worldwide. The molecular pathogenesis of HCC involves multiple signaling pathways. This study utilizes systems and bioinformatic approaches to investigate the pathogenesis of HCC.

Methods:
Gene expression microarray data were obtained from 50 patients with chronic hepatitis B and HCC. The 1649 differentially expressed genes were inferred from tumorous and nontumorous datasets. Weighted gene co-expression network analysis (WGCNA) was performed to construct clustered co-expressed gene modules. Statistical analysis was used to study the correlation between gene co-expression networks and demographic features of patients. Functional annotation and pathway inference were explored for each co-expression network. Network analysis identified hub genes of the prognostic gene co-expression network. The hub genes were further validated with a public database.

Result:
Five distinct gene co-expression networks were identified by WGCNA. A distinct co-expressed gene network was significantly correlated with HCC prognosis. Pathway analysis of this network revealed extensive integration with cell cycle regulation. Ten hub genes of this gene network were inferred from protein-protein interaction network analysis and further validated in an external validation dataset. Survival analysis showed that lower expression of the 10-gene signature had better overall survival and recurrence-free survival.

Conclusion:
This study identified a crucial gene co-expression network associated with the prognosis of HBV-related HCC. The identified hub genes may provide insights for HCC pathogenesis and may be potential prognostic markers or therapeutic targets.
Achievements of the Compendium Bencao Tujing (Illustrated Classic of Materia Medica): A Preliminary Study
Authors: Xiu Lin-Lin , Xu Shi-Chun , Wang Qi-Xuan , Chen Shao-Hong , Liu Hai-Yan , Zhong Gan-Sheng 
Published: July 2022

Abstract

Bencao Tujing (Illustrated Classic of Materia Medica) is a brilliant and monumental compendium of materia medica by Su Song, which was published in 1061 and gathered ancestral knowledge from the Song dynasty as a legacy for posterity. The compendium emphasized the clinical applications of medicinal materials collected nationwide, which used illustrated atlases as references. The descriptions for each medicinal material subsumed the prescriptions containing it and were supplemented with relevant medical cases. Medical prescriptions predating the Song dynasty were included, which enhanced the clinical usefulness of the pharmacopoeia. The ancestral knowledge of materia medica was extensively merged with natural history throughout the compendium, which also made extensive reference to more than 200 Chinese classics, local gazetteers, and published works from the social and natural sciences. The inclusion of natural history and literature works changed the convention used in earlier pharmacopoeias to present medicines based solely on pharmacological analyses. The compendium also pioneered the inclusion of natural history in pharmacopoeia. Bencao Tujing helped establish China's leading position in the field of materia medica. Su Song's meticulous nature, truth-seeking attitude, and adherence to scientific thinking are truly worthy of emulation and promotion.
Global research on vitamin D and coronavirus disease 2019: A bibliometric and visualized study
Authors: Shah Muhammad Waseem , Ahmad Tauseef , Khan Muhammad , Muhammad Shafi , Sun Guiju 
Published: July 2022

Background and aim:
Vitamin D play a substantial role in immune function, but little is known about its prevention in coronavirus disease 2019 (COVID-19). A detail bibliometric analysis of the published scientific literature indexed in Web of Science on vitamin D as a therapeutic option for the COVID-19 patients’ treatment is lacking. Thus, the current study was conducted to determine the key bibliometric indices and plot the global research on vitamin D and COVID-19.

Methods:
The Web of Science Core Collection database was utilized to retrieve publications on vitamin D and COVID-19. A Boolean search strategy was applied and the obtained data were exported to Microsoft Excel to generate relevant graphs. Furthermore, VOSviewer software version 1.6.17 for Windows was used to generate co-authorship countries, bibliographic coupling sources and co-occurrence keyword network visualization mapping. In addition, RStudio and Bibliometric online tool were used to generate WordCloud and thematic map, and intercountries relation map, respectively.

Results:
A total of 818 publications on vitamin D and COVID-19 were included in the final analysis. These publications were cited 10,713 times, with an H-index of 50. The number of publications and citations score from 2020 to November 2021 increased from 317 (2423 citations) to 501 (8290 citations). Delanghe JR and Speeckaert MM were the most prolific authors with 13 publications each. The most productive journal was Nutrients (n = 63). The most studied research area is nutrition dietetics. The most widely used author keywords were COVID-19 (n = 444), Vitamin D (n = 312), and SARS-CoV-2 (n = 190). The National Institute of Health and US Department of Health and Human Services were the leading funding agencies. Harvard University was the most active institution with 25 publications. The United States of America was the highly contributing and influential country in terms of publications (n = 203) and total link strength (n = 185).

Conclusion:
It was concluded that an increasing trend in the number of publications on vitamin D and COVID-19 has been observed. Significantly, the majority of the research has been conducted in developed countries. Most importantly, over the time, the direction of research has been changed and the recent trend topics are vitamin D deficiency, risk and infection, and vitamin D supplementation based on KeyWords Plus. The use of vitamin D supplement is one of the promising therapeutic options for COVID-19 treatment. Therefore, the current study not only highlight the global research trends but also provide standard bibliographic information for future studies.
Total failure of spinal anesthesia for cesarean delivery, associated factors, and outcomes: A retrospective case–control study
Authors: Punchuklang Wiruntri , Nivatpumin Patchareya , Jintadawong Thatchanan 
Published: July 2022

Spinal anesthesia is the anesthetic technique of choice for patients undergoing cesarean delivery. In the present study, total spinal anesthesia failure was defined as a case when an absent blockade or inadequate surgery required general anesthesia administration with an endotracheal tube. This study aimed to investigate factors related to this condition and report its maternal and neonatal outcomes.
This retrospective matched case–control study was conducted by recruiting 110 patients with failed spinal anesthesia and 330 control patients from September 1, 2016, to April 30, 2020, in the largest university hospital, Thailand.
Of 12,914 cesarean deliveries, 12,001 patients received single-shot spinal anesthesia (92.9%) during the study period. Total spinal anesthesia failure was experienced by 110/12,001 patients, giving an incidence of 0.9%. Factors related to the failures were a patient body mass index (BMI) ≤29.5 kg/m2 (adjusted odds ratio 1.9; 95% confidence interval 1.2–3.1; P = .010) and a third-year resident (the most senior trainee) performing the spinal block (adjusted odds ratio 2.4; 95% confidence interval 1.5–3.7; P < .001). In the group with failed spinal anesthesia, neonatal Apgar scores at 1 and 5 minutes were lower than those of the control group (both P < .001). Two patients in the failed spinal anesthesia group (2/110; 1.8%) had difficult airways and desaturation.
Independent factors associated with total spinal anesthesia failure were a BMI of ≤29.5 kg/m2 and a third-year resident performing the spinal block. Although the incidence of total failure was infrequent, there were negative consequences for the mothers and neonates. Adjusting the dose of bupivacaine according to the weight and height of a patient is recommended, with a higher dose appropriate for patients with a lower BMI.
Defining Prolonged Length of Stay (PLOS) Following Elective Laparoscopic Cholecystectomy and Derivation of a Preoperative Risk Score to Inform Resource Utilization, Risk Stratification, and Patient Consent
Authors: Lucocq James , Scollay John , Patil Pradeep 
Published: July 2022

Objective:
The present study defines prolonged length of stay (PLOS) following elective laparoscopic cholecystectomy (LC) and its relationship with perioperative morbidity. A preoperative risk tool to predict PLOS is derived to inform resource utilization, risk stratification and patient consent.

Background:
Surgical candidates for elective LC are a heterogeneous group at risk of various perioperative adverse outcomes. Preoperative recognition of high-risk patients for PLOS has implications on feasibility for day surgery, resource utilization, preoperative risk stratification, and patient consent.

Methods:
Data for all patients who underwent elective LC between January 2015 and January 2020 across 3 surgical centers (1 tertiary referral center and 2 satellite units) in 1 health board were collected retrospectively (n=2166). The optimal cut-off of PLOS as a proxy for operation-related adverse outcomes was found using receiver operating characteristic curves. Multivariate logistic regression was conducted on a derivation subcohort to derive a preoperative model predicting PLOS. Receiver operating characteristic curves were performed to validate the model. Patients were stratified by the risk tool and the risks of PLOS were determined.

Results:
A LOS of ≥3 days following elective LC demonstrated the best diagnostic ability for operation-related adverse outcomes [area under curve (AUC)=0.87] and defined the PLOS cut-off. The rate of PLOS was 6.6% (144/2166), 86.1% of which had a perioperative adverse outcome. PLOS was strongly associated with all adverse outcomes (subtotal, conversion-to-open, intraoperative complications, postoperative complication/imaging/intervention) (P<0.001). The preoperative model demonstrated good diagnostic ability for PLOS in the derivation (AUC=0.81) and validation cohorts (AUC=0.80) and stratified patients appropriately.

Conclusions:
Morbidity in PLOS patients is significant and pragmatic patient selection in accordance with the risk tool may help centers improve resource utilization, risk stratification, and their consent process. The risk tool may help select candidates for cholecystectomy in a strictly ambulatory/outpatient center.
Learning Curve of Laparoscopic Gastrectomy: A Multicenter Study
Authors: Brenkman Hylke J.F. , Claassen Linda , Hannink Gerjon , van der Werf Leonie R. , Ruurda Jelle P.-H. , Nieuwenhuizen Grard A.P. , Luyer Misha D.P. , Kouwenhoven Ewout A. , van Det Marc J. , van Berge Henegouwen Mark I. , Gisbertz Suzanne S. , Stoot Jan H.M.B. , Hulsewé Karel W.E. , van Workum Frans , van Hillegersberg Richard , Rosman Camiel 
Published: July 2022

Objective:
To evaluate the learning curve of laparoscopic gastrectomy (LG) after an implementation program.

Background:
Although LG is increasingly being performed worldwide, little is known about the learning curve.

Methods:
Consecutive patients who underwent elective LG for gastric adenocarcinoma with curative intent in each of the 5 highest-volume centers in the Netherlands were enrolled. Generalized additive models and a 2-piece model with a break point were used to determine the learning curve length. Analyses were corrected for casemix and were performed for LG and for the subgroups distal gastrectomy (LDG) and total gastrectomy (LTG). The learning curve effect was assessed for (1) anastomotic leakage; and (2) the occurrence of postoperative complications, conversions to open surgery, and short-term oncological parameters.

Results:
In total 540 patients were included for analysis, 108 patients from each center; 268 patients underwent LDG and 272 underwent LTG. First, for LG, no learning effect regarding anastomotic leakage could be identified: the rate of anastomotic leakage initially increased, then reached a plateau after 36 cases at 10% anastomotic leakage. Second, the level of overall complications reached a plateau after 20 cases, at 38% overall complications, and at 5% conversions. For both LDG and LTG, each considered separately, fluctuations in secondary outcomes and anastomotic leakage followed fluctuations in casemix.

Conclusion:
On the basis of our study of the first 108 procedures of LG in 5 high-volume centers with well-trained surgeons, no learning curve effect could be identified regarding anastomotic leakage. A learning curve effect was found with respect to overall complications and conversion rate.
Optic Disc Drusen in Patients With Ocular Hypertension: A Case Series and Review of the Literature
Authors: Kohli Darrell , Chen John J. , Bhatti M. Tariq , Moore-Weiss Jodi M. , Roddy Gavin W. 
Published: July 2022

Background:
The identification of glaucomatous optic neuropathy in the setting of optic disc drusen (ODD) is a challenge, and the decision of whether to offer treatment in the form of intraocular pressure (IOP) reduction is controversial. Here, we present a series of patients with coexisting ocular hypertension and ODD to evaluate clinical features, treatment options, and progression of optic neuropathy. In addition, a review of the literature on ODD with elevated IOP is provided.

Methods:
Six patients with ODD and a history of ocular hypertension are presented. Components of the examination and imaging modalities used to establish the diagnosis of ODD were recorded and a description of ocular hypertension history, glaucoma testing, and the potential treatment of IOP were also provided.

Results:
In this series, 4 of 6 patients with concurrent ocular hypertension and ODD showed progression of optic neuropathy as assessed by visual field or retinal nerve fiber layer thickness. Of the 2 patients who did not show evidence of progression, 1 was treated with IOP-lowering medications and 1 was observed off treatment. Of the 4 patients who showed evidence of progression, all 4 were initially treated with IOP-lowering medications and 2 ultimately went on to have trabeculectomy surgery. In the patients with progressive optic neuropathy, lowering the IOP seemed to halt the progression suggesting there was a pressure‐sensitive component.

Conclusions:
Distinguishing changes to the optic nerve, particularly the structural changes at the lamina cribrosa of true glaucomatous optic neuropathy in the setting of ODD, is a challenge. Careful consideration of risk factors including age, presenting features, progression indicators, and management goals is to be accounted for in the decision to offer treatment. We see the presence ODD in the patients with ocular hypertension as an additional risk for progressive changes to the nerve fiber layer and visual field that needs to be considered when determining whether to initiate therapy. Our data suggest that treatment of IOP in the patients with ocular hypertension with ODD and evidence of progression reduces the risk of further progression. Further work is needed to determine whether progression of optic neuropathy in the setting of coexisting ODD and ocular hypertension is related mechanistically to predominantly an ODD-type process, a glaucomatous process, or a combination thereof.
A Tale of Progressive Painless Vision Loss in a 64-Year-Old Man Due to Leber Hereditary Optic Neuropathy
Authors: Aung Moe H. , Volpe Nicholas J. , Choi Daniel J. , Stein Joel M. , Goldstein Amy , Liu Grant T. 
Published: July 2022

Abstract:
A 64-year-old man presented with painless sequential bilateral vision loss, consistent with optic neuropathy, over the span of months. The significant decline in his visual function was out of proportion to the appearance of the optic nerves (which were not pale) or changes in his retinal nerve fiber layer thickness on optical coherence tomography. Neuroimaging revealed only mild T2 signal abnormality and faint enhancement in the left optic nerve. Extensive workup for potential infectious, metabolic, inflammatory, and ischemic etiologies was unremarkable. Empiric treatment with intravenous steroids did not slow or ameliorate the vision loss. Ultimately, genetic analysis revealed a missense m.11778G>A mutation in mitochondrial MT-ND4 gene, consistent with Leber hereditary optic neuropathy. Initiation of multivitamin supplements and idebenone unfortunately did not result in recovery of vision.
FLUORESCE: A Pilot Randomized Clinical Trial of Fluoxetine for Vision Recovery After Acute Ischemic Stroke
Authors: Schneider Colleen L. , Prentiss Emily K. , Busza Ania , Williams Zoë R. , Mahon Bradford Z. , Sahin Bogachan 
Published: July 2022

Background:
Poststroke homonymous hemianopia is disabling, and complete spontaneous recovery is rare. In this randomized, placebo-controlled, double-blind, pilot clinical trial, we tested whether fluoxetine enhances vision recovery after stroke.

Methods:
We randomized 17 consecutive adults 1:1 to 90 days of fluoxetine 20 mg daily vs placebo within 10 days of an ischemic stroke causing isolated homonymous hemianopia. The primary end point was percent improvement in 24-2 automated perimetry at 6 months. Twelve participants completed the study. Clinical trial registration NCT02737930.

Results:
Intention-to-treat analysis of the primary end point, percent improvement in perimetric mean deviation, showed a nonsignificant benefit of fluoxetine (64.4%, n = 5) compared with placebo (26.0%, n = 7, one-tailed 95% confidence interval (CI) = (−2.13, ∞), P = 0.06). The original blind field completely recovered in 60% receiving fluoxetine and 14% receiving placebo (odds ratio = 7.22, one-tailed 95% CI = (0.50, ∞)).

Conclusion:
These results suggest a trend in favor of fluoxetine for vision recovery after stroke and have the potential to inform the design of a larger multicenter trial.