bluuebunny/crossref_metadata_2025_split huggingface dataset:
The transformation of the wrathful deity Mahākāla into the god of happiness and good luck Daikokuten in Japanese Buddhism.
Authors: Lepekhova Elena 
Published: July 2022

The transformation of the wrathful deity Mahākāla into the god of happiness and fortune Daikokuten in Japanese Buddhism. This study is devoted to the process of the transformation of the wrathful Hindu deity Mahākāla into the god of happiness and fortune Daikokuten in Japanese Buddhism. While in Hinduism and Vajrayāna Buddhism, Mahākāla was a wrathful deity, performing the functions of the Dharma protector, then as a result of the transference of this deity to the Japanese culture, his functions changed. The earliest examples of this process have been already marked in China, from where they later went to Japan. In the paper are traced the description of Mahākāla in the Japanese Buddhist textual tradition in the most notable Japanese text “Daikokutenjin-ho 大黒天神法” (“The Law of the Great Black God”), his iconography and the transformation in local folklore. The formation of Mahākāla iconography in Japan was influenced by a process of the Shintō-Buddhist syncretism, which combined the esoteric doctrines of the Tendai school, traditional Japanese Shintō mythology, Buddhist cosmology and related elements of Hinduism. All these trends are also well traced in Japanese folklore. As a sequence, we could come to conclusion that the process of transformation of the wrathful Hindu deity Mahākāla into one of the Japanese gods of happiness Daikokuten was influenced by the desire to rid Mahākāla of his original destructive deadly attributes, since they were not combined with the original Japanese Shintō tradition, referring to death and its manifestations as an impurity.
From a ‘Lass Kicker’ to ‘The Man’: WWE’s Irish Wrestler Becky Lynch and the Appropriation of Hegemonic Masculinity
Authors: Lydon Michael 
Published: July 2022

Since her World Wrestling Entertainment (WWE) debut (2014), Becky Lynch has become one of the best known popular cultural representations of transnationalised Irishness. In emerging victorious in the main event of Wrestlemania 35 (2019), Lynch cemented her place as WWE’s top Superstar. She thus became the first woman to achieve the accolade, completing her transition from a jig dancing ‘Lass Kicker’ to the sports entertainment conglomerate’s top star, or ‘The Man’.
In this article, I consider Lynch’s career in what Barthes’ considers the morally embedded theatrical performance that is professional wrestling. This entails assessing WWE as a ‘masculine melodrama’, a scripted form of popular entertainment with a long-standing tradition of asserting hegemonic masculinity. I outline WWE’s history of essentialising Irishness, before considering Lynch’s prominent position in WWE’s neoliberal feminist brandcasting. Finally, I show that fan appreciation for Lynch’s skill as a wrestler, and a ‘real’ moment of bloodshed, facilitated her use of the moniker ‘The Man’. Ultimately, I reveal that in being ‘The Man’, Lynch appropriated hegemonic masculine characteristics to challenge controversial normatives, while also signalling WWE’s neoliberal feminist emphasis on the importance of individual agency over industry accountability.

Keywords: Popular Culture; Irishness; Professional Wrestling; Hegemonic Masculinity; Neoliberal Feminism
A Community Marine Tourism as a Business Sector: Challenges Faced by Local Community
Authors: Suryani Adi , Soedarso Soedarso , Rahmawati Deti , Saifulloh Moh. , Agustin Dyah Satya Yoga 
Published: July 2022

Marine tourism is one of several economic drivers which contribute to local community livelihood and regional income. Many potential coastal areas are gradually developing and transformed by its’ local communities into local-scale tourisms which accommodate local or domestic or surrounding tourists’ recreational needs. However, to be sustainable, there are many issues need to be addressed. The study intends to explore Dalegan community perceived tourism issue in developing their WPP destination or white sand tourism. The study adopts qualitative method in gathering and analyzing the data. The data are gathered through Dalegan community dialog or interactive session during Dalegan community service program. The collected data are interpreted by implementing thematic analysis. The study reveals that there are three main issues faced by Dalegan local communities: financial, creativity and lack of legal procedures. The collaboration of financial service agents, educational institutions, (local) government bodies and local community inclusion is needed. The study demonstrates that to build Dalegan marine tourism, local/community leadership, local human quality improvement, local resources identification and local culture need to be used as the development grounds. The study also shows that the local community is still not aware of the environmental issues and diversification of recreational activities. Thus, local community still needs advocacy to understand the relationship between tourism and environment. The study also finds that local women are valuable human resource for marine tourism business. They are potential women entrepreneurs who develop small business around WPP marine tourism.
Pengaruh Fraksi Ukuran dan pH Pada Flotasi Mineral Sulfida
Authors: Subandrio Subandrio , Palit Christin , Marwanza Irfan , I. Emmy Fatmi B. , Juradi Muhammad Idris 
Published: July 2022

Peningkatan kadar unsur atau mineral dari bijih/ ore hasil penambangan biasanya selalu dilakukan dalam industri pertambangan, bagaimana menggoperasian peralatan secara optimal diperlukan kajian yang mendalam. Penelitian yang dilakukan bertujuan mengamati parameter-parameter mempengaruhi peningkatan kadar dengan metoda flotasi, alat flotasi memanfaatkan perbedaan sifat permukaan (kimia fisika) sehingga bisa memisahkan mineral sulfida dan pengotor. Bijih yang digunakan pada penelitian adalah bijih galena (PbS) merupakan salah satu jenis mineral sulfida. Percobaan dilakukan dengan memvariasikan beberapa variabel yaitu : ukuran umpan dengan rentang 140 - 325 mesh (105 – 44 mikron) , pH pulp dilakukan antara 7 – 11 dan waktu flotasi dilakukan antara 3 – 9 menit. Hasil percobaan memperlihatkan bahwa makin kecil ukuran umpan, kadar Pb (%) cenderung meningkat. Untuk pH pulp kadar Pb terbaik pada pH 9,5. makin tinngi pH gelembung yg terbentuk cenderung stabil sehingga material terangkat sempurna ke permukaan. Waktu flotasi terbaik didapat pada 6,5 menit. Waktu sangat berpengaruh terhadap keefektifan kerja reagent yg digunakan pada proses flotasi. Berdasarkan percobaan, hasil terbaik pada ukuran -200 + 230 mesh, pH 9,5 dan waktu retensi 6,5 menit yaitu dengan kadar Pb 27 % .
Environmental Impact of Ground Source Heat Pump Systems: A Comparative Investigation From South to North Europe
Authors: Aresti Lazaros , Florides Georgios A. , Skaliontas Andreas , Christodoulides Paul 
Published: July 2022

Ground Heat Exchangers (GHEs), buried in the ground either horizontally or vertically (in a borehole), are coupled with a heat pump to form a Ground Source Heat Pump (GSHP) system, which is a type of Renewable Energy System that exploits geothermal energy for space heating and cooling. GSHP systems are proposed as an alternative to conventional Air Source Heat Pumps (ASHPs) as they exhibit a higher efficiency. In this study, this difference in efficiency is tested in order to determine how the systems perform in terms of environmental impact. Three types of GSHP systems (with different GHE configuration), each compared to ASHPs, undergo a Life Cycle Analysis using the ReCiPe method from both mid-point and end-point perspectives. The heating and cooling loads required for a single residential building of area 220 m2, with nearly Zero Energy Building technical characteristics, is used as a Functional Unit, for seven cases (locations/countries) from South to North Europe. Additionally, a Simple Payback Period method is employed to investigate the CO2 payback time for the GSHPs. It is concluded that the use of GSHP systems in residential buildings, even with nZEB (nearly Zero Energy Buildings) characteristics of low heating/cooling demand, can be a more environmentally friendly solution than that of an ASHP system, depending on the factors affecting the system, namely the ground thermal characteristics, the heating/cooling demand, the heating/cooling peak loads and electricity mix.
Effect of Fecal Microbiota Transplantation on Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial
Authors: Xue Lanfeng , Deng Zhiliang , Luo Wenhui , He Xingxiang , Chen Yu 
Published: July 2022

Background and AimsThe clinical efficacy of fecal microbiota transplantation (FMT) in patients with non-alcoholic fatty liver disease (NAFLD) and the variant effects of FMT on lean and obese NAFLD patients remain elusive. Our study aimed to determine the clinical efficacy and safety of FMT for patients with NAFLD, elucidating its different influences on lean and obese patients with NAFLD.MethodsWe performed a randomized and controlled clinical trial. Patients in the non-FMT group were administered oral probiotics. In the FMT group, patients were randomized to receive FMT with donor stool (heterologous) via colonoscopy, followed by three enemas over 3 days. Both groups were also required to maintain a healthy diet and keep regular exercise for more than 40 min every day. They returned to the hospital for reexamination 1 month after treatment.ResultsFMT can decrease the fat accumulation in the liver by improving the gut microbiota dysbiosis, thus attenuating fatty liver disease. Significant differences in the clinical features and gut microbiota between lean and obese NAFLD patients were unveiled. Moreover, FMT had better effects on gut microbiota reconstruction in lean NAFLD than in obese NAFLD patients.ConclusionsFMT could successfully improve the therapeutic effects on patients with NAFLD, and its clinical efficacy was higher in lean NAFLD than in obese NAFLD patients.
Differential Effects of Genetically Determined Cholesterol Efflux Capacity on Coronary Artery Disease and Ischemic Stroke
Authors: Jin Aoming , Wang Mengxing , Chen Weiqi , Yan Hongyi , Xiang Xianglong , Pan Yuesong 
Published: July 2022

BackgroundObservational studies indicated that cholesterol efflux capacity (CEC) of high-density lipoprotein (HDL) is inversely associated with cardiovascular events, independently of the HDL cholesterol concentration. The aim of the study is to examine the casual relevance of CEC for coronary artery disease (CAD) and myocardial infarction (MI), and compare it with that for ischemic stroke and its subtypes using a Mendelian randomization approach.MethodsWe performed a 2-sample Mendelian randomization to estimate the casual relationship of CEC with the risk of CAD, MI, and ischemic stroke. A CEC-related genetic variant (rs141622900) and other five genetic variants were used as the instrumental variables. Association of genetic variants with CAD were estimated in a GWAS involving 60,801 CAD cases and 123,504 controls. They were then compared with the associations of these variants with ischemic stroke and its subtypes (large vessel, small vessel, and cardioembolic) involving 40,585 ischemic stroke cases and 406,111 controls.ResultsUsing the SNP of rs141622900 as the instrument, a 1-SD increase in CEC was associated with 45% lower risk for CAD (odds ratio [OR] 0.55, 95% confidence interval [CI] 0.44–0.69, p &lt; 0.001) and 33% lower risk for MI (odds ratio [OR] 0.67, 95% CI 0.52–0.87, p = 0.002). By contrast, the causal effect of CEC was much weaker for ischemic stroke (odds ratio [OR] 0.79, 95% CI 0.64–0.97, p = 0.02; p for heterogeneity = 0.03) and, in particular, for cardioembolic stroke (p for heterogeneity = 0.006) when compared with that for CAD. Results using five genetic variants as the instrument also indicated consistently weaker effects on ischemic stroke than on CAD.ConclusionGenetic predicted higher CEC may be associated with decreased risk of CAD. However, the casual association of CEC with ischemic stroke and specific subtypes would need to be validated in further Mendelian randomization studies.
Role of the Gut Microbiota in Glucose Metabolism During Heart Failure
Authors: Bao Pei , Zhang Zhiwei , Liang Yixiu , Yu Ziqing , Xiao Zilong , Wang Yucheng , Yu Yong , Liu Wen , Chen Xueying , Huang Zhenzhen , Su Yangang , Chen Ruizhen , Ge Junbo 
Published: July 2022

BackgroundBlood glucose disorders are prevalent in heart failure, while the influence of the gut microbiota on this process remains unclear. Here, we used heart failure model mice and fecal microbiota transplantation (FMT) mice to evaluate the effect of the gut microbiota on the regulation of blood glucose during heart failure.MethodsThoracic aortic constriction (TAC) surgery was performed in a heart failure model, while an antibiotic cocktail was used to eliminate the microbiota to establish a germ-free (GF) model. Blood glucose, insulin, and glucagon levels were measured, and an intraperitoneal glucose tolerance test (IPGTT) was performed. 16S rRNA sequencing and metabolomics were used to evaluate the changes in gut microbiota structure and metabolism induced by TAC. Another group of FMT mice was established to observe the effect of the gut microbiota on host metabolism.ResultsAfter microbiota clearance, the glucagon concentration, the homeostasis model assessment for insulin resistance (HOMA-IR), and the area under the curve (AUC) of the IPGTT were decreased significantly in the TAC germ-free (TAC-GF) group in the third month as compared to the other groups. 16S rRNA sequencing indicated that TAC surgery affected the gut microbiota structure, and fecal metabolomics suggested that noradrenaline and adrenaline levels were higher in the TAC group than in the sham group. The FMT mice transplanted with the feces of the TAC (FMT-TAC) mice displayed a higher AUC of IPGTT, accompanied by a higher glucagon level, insulin level, and HOMA-IR than those of the mice in the other groups. The serum metabolomics of the FMT-TAC group showed that noradrenaline levels were significantly higher than those of the FMT-sham group.ConclusionThe gut microbiota and its metabolism were altered during heart failure, which increased blood glucose and glucagon in the host.
Mortality and Clinical Predictors After Percutaneous Mitral Valve Repair for Secondary Mitral Regurgitation: A Systematic Review and Meta-Regression Analysis
Authors: Shi Wence , Zhang Wenchang , Zhang Da , Ye Guojie , Ding Chunhua 
Published: July 2022

BackgroundPercutaneous mitral valve repair (PMVR) provides an available choice for patients suffering from secondary mitral regurgitation (SMR), especially those whose symptoms persist after optimal, conventional, heart-failure therapy. However, conflicting results from clinical trials have created a problem in identifying patients who will benefit the most from PMVR.ObjectiveTo pool mortality data and assess clinical predictors after PMVR among patients with SMR. To this end, subgroup and meta-regression analyses were additionally performed.MethodsWe searched PubMed, EMBASE, and Cochrane databases, and 13 studies were finally included for meta-analysis. Estimated mortality and 95% confidence intervals (CIs) were obtained using a random-effects proportional meta-analysis. We also carried out a meta-regression analysis to clarify the potential influence of important covariates on mortality.ResultsA total of 1,259 patients with SMR who had undergone PMVR were enrolled in our meta-analysis. The long-term estimated pooled mortality of PMVR was 19.3% (95% CI: 13.6–25.1). Meta-regression analysis showed that mortality was directly proportional to cardiac resynchronization therapy (CRT) (β = 0.009; 95% CI: 0.002–0.016; p = 0.009), an effective regurgitant orifice (ERO) (β = 0.009; 95% CI: 0.000–0.018; p = 0.047), and a mineralocorticoid receptor antagonist (MRA) use (β = −0.015; 95% CI: −0.023–−0.006; p &lt; 0.001). Subgroup analysis indicated that patients with preexisting AF (β = −0.002; 95% CI: −0.005– −0.000; p = 0.018) were associated with decreased mortality if they received a mitral annuloplasty device. Among the edge-to-edge repair device group, a higher left ventricular (LV) ejection fraction, or lower LV end-systolic diameter, LV end-systolic volume, and LV end-diastolic volume were proportional to lower mortality.Conclusion and RelevanceThe pooled mortality of PMVR was 19.3% (95% CI: 13.6–25.1). Further meta-regression indicated that AF was associated with a better outcome in conjunction with the use of a mitral annuloplasty device, while better LV functioning predicted a better outcome after the implantation of an edge-to-edge repair device.
Electrical Conductivity of Eclogitic Omphacite and Garnet at Water-Rich Conditions
Authors: Liu Hanyong , Yang Xiaozhi 
Published: July 2022

Electrical conductivity of water-rich omphacite and garnet in eclogite was measured at 1 GPa and 200–800°C in a piston cylinder press and by a Solartron-1260 impedance/gain-phase analyzer at 106-1 Hz frequency. The water content of pre-annealed omphacite and garnet was 775–2,000 and 705–1,460 ppm H2O, respectively. Sample chemistry and water contents remained unchanged during conductivity runs. At otherwise identical conditions, the conductivity of both minerals increases with both temperature and water content, and the water content exponent is ∼1.45 and 1.12 for omphacite and garnet, respectively. The activation enthalpy is ∼70 kJ/mol for omphacite and 84 kJ/mol for garnet and is broadly independent of sample water content. Combining with previous work, the conductivity dependence of omphacite on water content differs between water-rich and water-poor conditions, due to different types and mobility of water in samples that are closely related to its incorporation mechanism; in contrast, the conductivity dependence of garnet with a similar type of water is comparable over a wide range of water contents. The estimated bulk conductivity of eclogite at water-rich conditions is very high, up to ∼0.01–0.1 S/m at 600–900°C. Geophysically resolved high resistivity of subducting crusts at 70–120 km depth suggests extremely low water contents of omphacite and garnet in the eclogitized slab. The data provide support to the model based on omphacite and garnet conductivity at water-poor conditions that the amount of water recycled by crust subduction to the deep mantle is probably limited.
Association Between Thyroid Dysfunction and Incidence of Atrial Fibrillation in Patients With Hypertrophic Obstructive Cardiomyopathy
Authors: Meng Xiangbin , Wang Xu-Liang , Zhang Zhi-yuan , Zhang Kuo , Gao Jun , Zheng Ji-lin , Wang Jing-Jia , Liu Yu-peng , Yang Jie , Li Chen , Zheng Yi-Tian , Shao Chunli , Wang Wen-Yao , Tang Yi-Da 
Published: July 2022

ObjectiveTo explore the correlation between the incidence of atrial fibrillation (AF) and thyroid dysfunction in patients with hypertrophic obstructive cardiomyopathy (HOCM).MethodsThyroid function testing in 755 consecutive patients with HOCM were examined at the National Center for Cardiovascular Diseases (China) from October 2009 to December 2013. Patients were divided into four groups according to the TSH levels: TSH&lt;0.55 mIU/L(n=37)、0.55~2.49 mIU/L (n=490)、2.50~9.9 mIU/L (n=211) and &gt;10.00mIU/L(n=17).ResultsA total of 107 patients were diagnosed with AF (14%).(1) Compared to HOCM patients without AF,HOCM patients with AF have older age (P&lt;0.001), higher NT-proBNP (P=0.002), higher Cr (P=0.005), larger left atrial diameter(P=0.001), lower FT3 (P=0.046), higher FT4 (P=0.004).(2) In the four groups according to the TSH levels: TSH&lt;0.55 mIU/L, 0.55~2.49mIU/L, 2.50~9.9mIU/L and ≥10.00mIU/L, the incidence of AF was 27.02%(10/37),10.20%(50/490), 19.43%(41/211), and 35.29%(6/17), respectively. Both high and low TSH levels were associated with an increased incidence of AF. After adjusting for the common risk factor (age, NT-proBNP, and so on), stepwise multiple logistic regression analysis revealed that TSH levels were significantly related to AF incidence.Compared to patients with TSH 0.55~2.49 mlU/L, the adjusted odds ratio of AF for TSH&lt;0.55, 2.50~9.99, ≥10.00 mIU/L were 1.481 (95% CI 0.485~4.518,P=0.490), 1.977 (95%CI 1.115~3.506, p=0.02), 4.301 (95%CI 1.059~17.476, P=0.041), respectively.ConclusionOur results suggested that thyroid dysfunction was associated with an increased risk of AF in patients with HOCM.
Further Introduction of DNA Methylation (DNAm) Arrays in Regular Diagnostics
Authors: Mannens M. M. A. M. , Lombardi M. P. , Alders M. , Henneman P. , Bliek J. 
Published: July 2022

Methylation tests have been used for decades in regular DNA diagnostics focusing primarily on Imprinting disorders or specific loci annotated to specific disease associated gene promotors. With the introduction of DNA methylation (DNAm) arrays such as the Illumina Infinium HumanMethylation450 Beadchip array or the Illumina Infinium Methylation EPIC Beadchip array (850 k), it has become feasible to study the epigenome in a timely and cost-effective way. This has led to new insights regarding the complexity of well-studied imprinting disorders such as the Beckwith Wiedemann syndrome, but it has also led to the introduction of tests such as EpiSign, implemented as a diagnostic test in which a single array experiment can be compared to databases with known episignatures of multiple genetic disorders, especially neurodevelopmental disorders. The successful use of such DNAm tests is rapidly expanding. More and more disorders are found to be associated with discrete episignatures which enables fast and definite diagnoses, as we have shown. The first examples of environmentally induced clinical disorders characterized by discrete aberrant DNAm are discussed underlining the broad application of DNAm testing in regular diagnostics. Here we discuss exemplary findings in our laboratory covering this broad range of applications and we discuss further use of DNAm tests in the near future.