bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lessons learned designing and implementing a quality assurance system in an industrial engineering school
Authors: Benz-Camino Mariechen , Ramírez-Valdivia Martha T. , Morales-Casetti Marjorie , Sirias Danilo 
Published: November 2022

Purpose
This paper aims to present the lessons learned during the design and implementation of a quality assurance system (QAS) in an academic unit and considers the regulatory changes to institutional accreditation in Chilean higher education, the international standard ISO 21001:2018, and the stakeholders’ requirements.

Design/methodology/approach
This study uses an abductive approach to identify and evaluate the key factors to implementing a QAS in higher education institutions (HEI). Qualitative and quantitative data were collected through questionnaires, semistructured interviews, focus groups with stakeholders, a literature review and official institutional documents. Documents and interviews were subjected to content analysis using a process of inductive coding to identify and define topics or categories. A descriptive statistical analysis of categorical variables calculated the marginal frequency of each response. All information aided in designing the QAS for the school and its implementation plan.

Findings
This study highlights major challenges universities could face while implementing QAS, illuminating key principles and reflecting relevant practices. The lessons learned in this process show the importance of balancing accountability and continuous improvement while promoting a more receptive organizational culture, aligning the national and international standards in the early design stage, understanding the roles and responsibilities of the staff, having the support of a quality office and performing a gap analysis.

Originality/value
This work provides other HEI in need of designing and implementing a QAS with a conceptual and solid framework to integrate internal, external and international regulations of quality assurance criteria and standards. This paper could become a valuable reference for university managers, practitioners and quality professionals facing similar challenges.
Variation in outcome reporting in studies of fertility‐sparing surgery for cervical cancer: A systematic review
Authors: Yong Nathanael , Cooper Natalie , Yorke Sarah , Baran Chawan , Khan Khalid , Tan Alex , Sideris Michail , Iliodromiti Stamatina , Manchanda Ranjit 
Published: November 2022

AbstractBackgroundCervical cancer affects 3197 women in the UK, and 604 000 women worldwide annually, with peak incidence seen in women between 30 and 34 years of age. For many, fertility‐sparing surgery is an appealing option where possible. However, absence of large‐scale data, along with a notable variation in reported outcomes in relevant studies, may undermine future efforts for consistent evidence synthesis.ObjectivesTo systematically review the reported outcomes measured in studies that include women who underwent fertility‐sparing surgery for cervical cancer and identify whether variation exists.Search strategyWe searched MEDLINE, EMBASE and CENTRAL from inception to February 2019.Selection criteriaRandomised controlled trials, cohort and observational studies, and case studies of more than ten participants from January 1990 to date.Data collection and analysisStudy characteristics and all reported treatment outcomes.Main resultsA total of 104 studies with a sum of 9535 participants were identified. Most studies reported on oncological outcomes (97/104), followed by fertility and pregnancy (86/104), postoperative complications (74/104), intra‐operative complications (72/104) and quality of life (5/104). There was huge variation and heterogeneity in reported outcomes, with only 12% being good quality and 87% being of poor quality.ConclusionsThere is significant heterogeneity in the reported outcomes. An agreed Core Outcome Set is necessary for future studies to effectively harmonise reported outcomes that are measurable and relevant to patients, clinicians and researchers. This systematic review sets the groundwork for the development of a Core Outcome Set for fertility‐sparing surgery in cervical cancer.
Improving the chemical and sensory characteristics of red and white wines with pectinase‐producing non‐Saccharomyces yeasts
Authors: Paup Victoria D. , Barton Tara L. , Edwards Charles G. , Lange Iris , Lange B. Markus , Lee Jungmin , Ross Carolyn F. 
Published: November 2022

AbstractThis study examined the influence of pectinase‐producing non‐Saccharomyces yeasts on the chemical and sensory attributes of red and white wines with added pectin. Merlot and Chardonnay wines were produced with or without a mixture of pectinase‐producing non‐Saccharomyces yeasts (Cryptococcus adeliensis, Issatchenkia orientalis, and Pichia kluyveri) added to the must prior to alcoholic fermentation conducted by a commercial strain of Saccharomyces cerevisiae. To ensure sufficient substrate was present, varying concentrations of apple pectin (up to 1.25 g/L for red wines and 1.00 g/L for white wine) were added at the start of fermentation. After bottling, trained panelists (n = 10) analyzed these wines for aroma, flavor, taste, and mouthfeel attributes. For both wines, significant interactions were noted between the presence of non‐Saccharomyces yeasts and pectin addition which affected pH, titratable acidity, and concentrations of D‐galacturonic acid. While no significant sensory differences were observed among the red wines, limited changes were noted for white wines. However, a strong positive correlation was found between the D‐galacturonic acid and buttery aroma for Chardonnay and with flavor for Merlot. Increasing D‐galacturonic acid concentrations, through utilization of non‐Saccharomyces yeasts, may improve the wine quality as a buttery aroma is often associated with high‐quality Chardonnay. For both red and white wines, the utilization of these particular non‐Saccharomyces yeasts significantly influenced chemical properties but yielded minor sensory changes without any faults.Practical ApplicationWith the recent trend to reduce alcohol content in commercial wines, the interest in non‐Saccharomyces yeasts has grown. This study showed that the addition of non‐Saccharomyces yeasts, perhaps due to their pectinase activity, influenced the chemical characteristics of red and white wines with limited sensory differences, making these yeasts a useful tool for winemakers to modify wine properties.
On advance payments in tenders with budget constrained contractors
Authors: Birulin Oleksii , Izmalkov Sergei 
Published: November 2022

AbstractWe consider procurement auctions in settings where potential contractors have limited funds and face ex post risks, that is, cost overruns that can lead to the contractors' defaults. The bidding strategies and the default decisions are shaped by the incentive—willing to finish—constraints, and the resource—able to finish and feasibility—constraints. We examine payment schemes where the advance share of the award is paid immediately after the auction with the rest payable upon successful completion of the project. We identify the trade‐offs the procurer faces when choosing among such schemes, and explore the factors that influence the optimal advance share.
Austria: Political Developments and Data in 2021
Authors: JENNY MARCELO , HOFER SIMON 
Published: November 2022

AbstractThis entry includes data on changes in national government composition, party leadership changes and parliamentary composition in Austria in 2021, as well as election results from a subnational election. It covers the Austrian coalition government between the Austrian People's Party (ÖVP) and the Greens, led by Sebastian Kurz, in the second year of handling the Covid‐19 pandemic. Judicial and parliamentary investigations of politicians and Cabinet officials from the Austrian People's Party, including Federal Chancellor and ÖVP party leader Kurz, resulted in the latter's retreat from politics. Over the course of the year, the federal government was led by three different Federal Chancellors from the ÖVP.
Diagnostic accuracy for self‐reported methamphetamine use versus oral fluid test as the reference standard in a methamphetamine‐dependent intervention trial population
Authors: Carter Gregory , Spittal Matthew J. , Glowacki Linda , Gerostamoulos Dimitri , Dietze Paul , Sinclair Barbara , Arunogiri Shalini , Berk Michael , Lubman Dan I. , Manning Victoria , Higgs Peter , Quinn Brendan , Baker Amanda , Dean Olivia M. , Turner Alyna , McKetin Rebecca 
Published: November 2022

AbstractAimsTreatment of methamphetamine dependence requires monitoring of recent use or abstinence. Self‐report is commonly used for routine monitoring, but the accuracy of self‐report is not established. For the treating clinician, the key accuracy statistic is the negative predictive value (NPV). The study aim was to estimate the NPV of self‐reported non‐use of methamphetamine compared with an oral fluid reference standard.Design, Setting and ParticipantsThis study was a secondary (subgroup) analysis from a randomized controlled pharmacotherapy trial. Three Australian outpatient addiction services took part. Particpants were 139 people dependent on methamphetamine.MeasurementsWeekly oral fluid samples over 12 weeks to determine methamphetamine (and amphetamine) concentrations were used as the reference standard. Self‐report of any methamphetamine use in the previous 7 days by the time‐line follow‐back method was the index test. Standard diagnostic accuracy statistics were calculated for all available paired episodes (n = 1134). Three NPV values were calculated: unadjusted NPV and NPV adjusted for clustering of observations through logistic regression and generalized estimating equation (GEE). We also calculated the NPVs for a range of prevalence rates of methamphetamine use, for the calculated levels of sensitivity and specificity.FindingsSensitivity was 96.4% [95% confidence interval (CI) = 95–97.5], specificity was 63.7% (95% CI = 57.3–69.8) and positive predictive value (PPV) was 90.8% (95% CI = 88.8–92.6). The unadjusted NPV was 82.7% (95% CI = 76.5–87.9), adjusted NPV by logistic regression 82.7% (95% CI = 73.9–91.5) and GEE 76.8% (95% CI = 66.8–86.8). At a methamphetamine use prevalence of 5%, the estimated NPV would be 99.7% (95% CI = 99.6–99.9) and at 95% prevalence, 48.2% (95% CI = 39.6–57.0).ConclusionsSelf‐report of no recent methamphetamine use appears to be sufficiently accurate to be clinically useful at the expected prevalence rates of methamphetamine use in clinical treatment settings. If generalizable to clinical settings, where these tests are routinely conducted, this may permit a reduction in the frequency and cost of oral fluid assays.
Does loving‐kindness meditation elicit empathic emotions? The moderating role of self‐discrepancy and self‐esteem on guilt
Authors: Carrero Isabel , Martínez de Ibarreta Carlos , Valor Carmen , Merino Amparo 
Published: November 2022

AbstractOur understanding of the emotions elicited by loving‐kindness meditation (LKM) at early stages of practice is limited, despite the influence that these emotions may have on later engagement. Past work suggests that LKM may elicit emotional ambivalence at early stages of the practice, but it is still unclear whether the content of LKM activates this ambivalence and who is more likely to experience it. Given the specific content of LKM, we defend that this meditation is likely to elicit empathetic emotions, both positive (compassion and gratitude) and negative (guilt), to a greater extent than an active control. Guilt is likely to be elicited by memories of incidents where naïve meditators were not able to experience compassion and/or by the difficulties in sending compassionate love to disliked others during the meditation. Furthermore, individuals with greater self‐discrepancy and lower self‐esteem are more likely to experience guilt. These hypotheses were tested in two experimental studies with community and student samples (n = 55 and n = 33, respectively) and using a brief intervention. The results support the hypotheses. These findings have implications for instructors of LKM, especially when organizing meditation practices with naïve meditators who should be aware of the potential negative emotions elicited by this meditation.
Questioning quotation: Writing about interview experiences without using quotes
Authors: Bissell David 
Published: November 2022

AbstractIt is expected that we present participant quotes when writing up qualitative interview research. Yet doing so carries the risk of making our participants' lives seem too neat and can give the misplaced illusion that we have easily made sense of their situation. This paper explores other ways that we might work with interviews that are more sensitive to the complexities of interview encounters themselves. Through reflection on an interview with a rideshare driver that challenged my interpretive capacities, I explore other ways of writing up interviews that do not use quotes. The paper invites us to consider occasions where it might be more advantageous to produce a narrative description of what it was like to do the interview itself, or to write a narrative response to the interview.
Design, synthesis, and modelling study of new 1,2,3‐triazole/chalcone hybrids with antiproliferative action as epidermal growth factor receptor inhibitors
Authors: Maghraby Mohamed T.‐E. , Salem Ola I. A. , Youssif Bahaa G. M. , Sheha Mahmoud M. 
Published: November 2022

AbstractA novel series of 1,2,3‐triazole/chalcone hybrids 6a–n was designed and synthesized using a molecular hybridization approach to develop a new cytotoxic agent capable of targeting epidermal growth factor receptor (EGFR) and/or BRAF. The antiproliferative effect of the novel hybrids was investigated against four cancer cells using doxorubicin as a reference. Hybrids 6a, 6d, 6f–h, and 6n have the highest antiproliferative activity (IC50 values 0.95–1.80 μM) compared to doxorubicin (IC50 1.14 μM). The most potent antiproliferative derivative, compound 6d, was also the most potent EGFR inhibitor with an IC50 of 0.09 ± 0.05 μM, which is comparable to the reference Erlotinib (IC50 = 0.05 ± 0.03 μM). 6d has modest BRAF inhibitory action with an IC50 of 0.90 ± 0.10 μM. The findings were also related to molecular docking studies, which provided models of strong interactions with the EGFR‐TK domain for the inhibitors. In cell cycle analysis, hybrid 6d caused a cell cycle arrest at the G1 transition phase.
Design, synthesis, and biological evaluation of novel ruxolitinib and baricitinib analogues for potential use against COVID‐19
Authors: Lin Qin , Li Jun , Wang Yinping , Zang Jie 
Published: November 2022

AbstractThe coronavirus pandemic known as COVID‐19 caused by severe acute respiratory syndrome coronavirus 2, threatens public health worldwide. Approval of COVID‐19 vaccines and antiviral drugs have greatly reduced the severe cases and mortality rate. However, the continuous mutations of viruses are challenging the efficacies of vaccines and antiviral drugs. A drug repurposing campaign has identified two JAK1/2 inhibitors ruxolitinib and baricitinib as potential antiviral drugs. Ruxolitinib and baricitinib exert dual antiviral effect by modulation of inflammatory response via JAK1/2 and inhibition of viral entry via AAK1 and GAK. Inspired by this, in an effort to diversify chemical space, three analogues ((R)‐8, (S)‐8, and 9) of ruxolitinib and baricitinb were made using a scaffold hopping strategy. Compound 9 displayed potent and comparable potencies against AAK1, JAK1, and JAK2 compared to baricitinib. Notably, compound 9 showed better selectivity for AAK1, JAK1, and JAK2 over GAK. Besides, compound 9 displayed good druglikeness according to Lipinski's and Veber's rule. We thereby identified a potential lead compound 9, which might be used for the further development of anti‐coronaviral therapy.
Histopathological features of pemphigoid gestationis and polymorphic eruption of pregnancy: A blinded retrospective comparative study of 31 cases
Authors: Baban Farah , Xie Fangyi , Lehman Julia S. , Theiler Regan , Todd Austin , Davis Dawn M. , Johnson Emma F. 
Published: November 2022

AbstractBackgroundPemphigoid gestationis (PG) and polymorphic eruption of pregnancy (PEP) are pregnancy‐related dermatoses. Definitive diagnosis often relies upon histopathology and direct immunofluorescence (DIF). PG is associated with fetal and neonatal risks, while PEP confers minimal risk.ObjectiveWe aimed to compare histopathologic features to determine key differentiators.MethodsA retrospective cohort study of PG and PEP cases, with accompanying DIF, conducted from 1995 to 2020. Skin biopsies were examined independently in a blinded fashion by two dermatopathologists for a list of histopathological features.ResultsTwenty‐one cases of PG and 10 cases of PEP were identified. PG had significantly denser eosinophils than PEP (mean 155 vs. 48 cells/5 hpf; p < 0.018). PG was also noted to have eosinophilic spongiosis and eosinophils at the dermal–epidermal junction more frequently compared to PEP (80% PG vs. 10% PEP; p < 0.001). A mean cutoff value of 86 eosinophils and a mean optimal sensitivity and specificity of 81% and 83%, respectively, for eosinophils density's diagnostic power of PEP versus PG were achieved. Subepithelial separation was exclusively seen in PG (40% vs. 0%; p < 0.007).ConclusionEosinophilic spongiosis, eosinophilic epitheliotropism, and dense superficial dermal eosinophils were diagnostic of PG. Given overlapping clinicopathologic features, however, DIF results with clinicopathologic correlation, remain the gold standard.
Fast adjustment of pace‐of‐life and risk‐taking to changes in food quality by altered gene expression in house mice
Authors: Prabh Neel , Linnenbrink Miriam , Jovicic Milan , Guenther Anja 
Published: November 2022

AbstractThe pace‐of‐life syndrome hypothesis provides a framework for the adaptive integration of behaviour, physiology and life history between and within species. It suggests that behaviours involving a risk of death or injury should co‐vary with a higher allocation to fast reproduction. Empirical support for this hypothesis is mixed, presumably because important influencing factors such as environmental variation, are usually neglected. By experimentally manipulating food quality of wild mice living under semi‐natural conditions for three generations, we show that individuals adjust their life history strategies and risk‐taking behaviours as well as trait covariation (Nindividuals = 1442). These phenotypic differences are correlated to differences in transcriptomic gene expression of primary metabolic processes in the liver while no changes in gene frequencies occurred. Our discussion emphasises the need to integrate the role of environmental conditions and phenotypic plasticity in shaping relationships among behaviour, physiology and life history in response to changing environmental conditions.
Low genetic diversity, local‐scale structure, and distinct genetic integrity of Korean chum salmon (Oncorhynchus keta) at the species range margin suggest a priority for conservation efforts
Authors: Jang Ji Eun , Kim Ju Kyoung , Yoon Seung‐Min , Lee Hwang‐Goo , Lee Wan‐Ok , Kang Ji Hyoun , Lee Hyuk Je 
Published: November 2022

AbstractChum salmon (Oncorhynchus keta) is an ecologically and economically important species widely distributed across the North Pacific Ocean. However, the population size of this fishery resource has declined globally. Identifying genetic integrity, diversity and structure, and phylogenetic relationships of wild populations of O. keta over an entire species' range is central for developing its effective conservation and management plans. Nevertheless, chum salmon from the Korean Peninsula, which are comprised of its southwestern range margins, have been overlooked. By using mtDNA control region and 10 microsatellite loci, we here assessed the genetic diversity and structure for 16 populations, including 10 wild and six hatchery populations, encompassing the species entire geographic range in South Korea. The analyses showed that genetic diversity is significantly higher for wild than for hatchery populations. Both marker sets revealed significant genetic differentiation between some local populations. Comparisons of six wild and their respective hatchery populations indicated that allele/haplotype frequencies considerably differ, perhaps due to a strong founder effect and/or homogenizing of hatchery populations for stocking practice. Despite its single admixed gene pool for the Korean chum salmon, some local populations housing their own unique lineages should be accorded with a high priority to safeguard their genetic integrities. The results of our comparative analyses of the Korean population with other North Pacific chum salmons (inhabiting regions of Japan, Russia, and North America) revealed a lower diversity but higher contribution to the overall species‐level genetic diversity, and also its unique genetic integrity. These findings advocate for the evolutionary significance of the Korean population for species‐level conservation.
Global epidemiology of factor XI deficiency: A targeted review of the literature and foundation reports
Authors: Zhang Xinruo , Lewandowska Magdalena , Aldridge Molly , Iglay Kristy , Wolford Eric , Shapiro Amy 
Published: November 2022

AbstractIntroductionHereditary factor XI (FXI) deficiency is a rare coagulation disorder that may result in excessive bleeding requiring intervention to restore haemostasis.AimThe aim of this review was to report the current knowledge of the worldwide incidence and prevalence of FXI deficiency.MethodsA targeted PubMed search using terms related to FXI deficiency was conducted to identify studies published from April 2002 through April 2022. A manual search supplemented the electronic search. Studies were eligible for data abstraction if they reported population‐based incidence proportions/rates or prevalence proportions for FXI deficiency.ResultsThe electronic and manual searches returned 253 publications. After applying exclusion criteria, seven publications were included in the analysis, including a global report from the World Federation of Haemophilia (WFH). Six publications provided information on the prevalence of FXI deficiency that included 74 countries and regions. The estimated prevalence of FXI in the WFH report ranged from 0/100,000 in several countries to 55.85/100,000 individuals in the United Kingdom. Prevalence estimates in the PubMed findings ranged from .1 to 246.2/1,000,000 inhabitants with varying methods of case identification and time periods of analysis. One study estimated the incidence of FXI deficiency in Yecla, Spain at 2% of blood donors and .09% of hospital inpatients/outpatients with activated partial thromboplastin time (aPTT) tests.ConclusionFXI deficiency is rare across the world, but additional steps could be taken to improve incidence and prevalence estimation, for example, development of a consistent FXI deficiency definition and incorporating genetic testing into a clinical routine to better identify and characterise cases.