bluuebunny/crossref_metadata_2025_split huggingface dataset:
12 years of Male Breast Cancer Experience at One Center
Authors: Çarkit Sedat , Oz Bahadir , Gok Mustafa , Akcan Alper Celal , Karaagac Mustafa , Aslan Dicle , Mutlu Emel , Solak Ismail , Sozuer Erdogan Mutevelli 
Published: January 2025

Abstract:

Background
Male breast cancer is a sporadic disease and only one in every 100 new breast cancer patients is male. There are few satisfactory clinical studies on male breast cancers in the literature. We aim to share the clinicopathologic and demographic characteristics of male breast cancer patients admitted to our clinic in the last 12 years and our experience in the treatment of these patients.

Methods
The data of patients who were referred to our clinic with a diagnosis of breast cancer, suspicion of breast cancer, or who presented to our outpatient clinic with symptoms of breast discharge, palpable mass in the breast and were diagnosed with breast malignancy or suspicion of malignancy between 2010 and 2022 were retrospectively evaluated from the data bank records of our hospital. 28 patients were included in the study. Patients' clinical and pathologic data, treatment options, approach to the axilla, pathology results, and survival were evaluated.

Results
There were 28 patients in the research. 22 had mastectomies. No surgical intervention was carried out for the five patients who had metastases. One of these patients died during follow-up due to advanced comorbidities and metastatic disease. Another patient declined surgery following neoadjuvant chemotherapy and passed away during follow-up (ex). The third patient passed away during neoadjuvant chemotherapy, and two patients are still undergoing neoadjuvant treatment.

Conclusion
Male breast cancers are rare diseases. RT after mastectomy increases survival in male patients as well as in female patients. However, RT in male patients is not standardized today. In our study, 15 patients received adjuvant RT.
Da Sala de Aula aos Ambientes Virtuais: explorando a intersecção bibliométrica entre educação, propriedade intelectual, metaverso e realidade virtual
Authors: Silva Flaviano da , Alves Larissa Oliveira , Silva Alandey Severo Leite da 
Published: January 2025

Este estudo teve como objetivo mapear a produção científica no campo da educação, fundamentado na intersecção entre a educação, a propriedade intelectual, o metaverso e a realidade virtual. Os dados oriundos desse mapeamento foram coletados a partir da plataforma Scopus e analisados com o suporte das ferramentas de software RStudio e Biblioshiny. Os termos utilizados para a busca foram “Education” and “Intellectual Property” and “Metaverse” or “Virtual Reality”. A análise revelou um número limitado de publicações dedicadas a esse tema nos campos de estudo propostos, identificando apenas sete artigos. A produção científica de artigos oscilou ao longo dos anos de 1999 e 2024, com pico em 2023. A China se destacou como o país com a maior produção científica, com duas publicações. Cada periódico envolvido neste estudo contribuiu com a publicação de um artigo. Além disso, o estudo apresentou 12 temas de pesquisas relevantes e 10 temas de tendência para o campo de estudo aqui investigado.
Educação Empreendedora na Visão dos Estudantes dos Cursos Superiores do Instituto Federal do Acre (IFAC)
Authors: Miranda Manuele Silva de , Lacerda Mylena Figueiredo , Satrapa Herika Fernanda Montilla , Ferreira Junior Genildo Cavalcante 
Published: January 2025

O empreendedorismo desempenha um papel crucial na dinâmica econômica atual, sendo uma força impulsionadora de inovação, crescimento e transformação. O interesse pela educação empreendedora cresceu significativamente nos últimos anos, estimulando novas abordagens voltadas para a formação empreendedora. Nesse contexto, este estudo tem como objetivo analisar o ensino do empreendedorismo nos cursos superiores do Instituto Federal do Acre (IFAC), Câmpus Rio Branco. Todos os estudantes do ensino superior do câmpus (549) foram convidados para participar da pesquisa por meio do preenchimento de um questionário on-line estruturado com 20 perguntas objetivas. Houve adesão na pesquisa de 94 estudantes (17,12%). Os resultados evidenciaram um baixo perfil de vocação empreendedora, embora a instituição fomente iniciativas nesse sentido. No entanto, destaca-se a necessidade de maior integração das práticas empreendedoras ao currículo acadêmico, bem como a importância de oferecer capacitação docente e de estratégias mais robustas para promover o empreendedorismo no ambiente acadêmico.
GÊNERO E SEXUALIDADE SOB A ANÁLISE ARQUEGENEÁLOGA DO SABER-PODER
Authors: Toni Junior Claudio Noel de 
Published: January 2025

Por meio de leituras das obras de autores da Filosofia francesa como Bourdieu e Foucault, discorrem os clássicos citados como forma de percepção das desigualdades sociais, econômicas e de gênero nas sociedades capitalistas sobre formas de dominação. Dominação masculina nas obras de Bourdieu, do capital econômico que geram desigualdades em que muitos detém a maior parte da riqueza entre as nações, ao formar classes inteligíveis e aquelas que não tem direitos a uma vida digna de proteção do Estado. Além das desigualdades sociais e simbólicas e de como o sujeito pode se reinventar através de lutas e resistências em um mundo líquido e desigual, na busca de novas formas de viver, para que nas esferas socioeconômicas e simbólicas se possa deixar viver pela resistência e pelo governo de si. O objetivo do artigo é a descrição de que as pessoas possuem regramento jurídico aparentemente iguais perante a lei, mas que, na prática a intolerância de raças, gênero, além das desigualdades socioeconômicas, do branco pobre, por exemplo, faz com que sejam minimizados direitos das classes com menores chances de vencer o poder, como a comunidade LGBTQIA+. A relevância e importância do artigo vai além da mensuração socioeconômica dos indivíduos e se comunica com interações simbólicas do ser e do ter, na questão moral e ética de como o sujeito pode se governar a si e aos outros, mesmo vivendo em um país desigual como o Brasil.
Capturing mechanisms of change: Weekly covariation in anger regulation, hostile intent attribution, and children's aggression
Authors: Alsem Sophie C. , Keulen Janna , Verhulp Esmée E. , van Dijk Anouk , De Castro Bram O. 
Published: January 2022

AbstractInterventions for children's aggression typically target assumed underlying mechanisms, such as anger regulation and hostile intent attribution. The expectation here is that targeting these mechanisms will result in within‐person changes in aggression. However, evidence for these mechanisms is mostly based on between‐person analyses. We, therefore, examined whether within‐person changes in adaptive anger regulation and hostile intent attribution covaried with within‐person changes in children's aggression. Children (N = 223; age 7–12; 46% boys) filled out four weekly report measures to assess adaptive anger regulation, hostile intent attribution, and aggression. The psychometric properties of these novel measures were adequate. Results of multi‐level analyses revealed within‐person effects: weekly changes in adaptive anger regulation and hostile intent attribution covaried with changes in children's aggression. This corresponded with between‐person findings on the same data: children with lower levels of adaptive anger regulation and higher levels of hostile intent attribution reported more aggression than other children. These findings support the idea that targeting anger regulation and hostile intent attribution in interventions may lead to changes in individual children's aggression.
Optimization of 99mTc whole‐body SPECT/CT image quality: A phantom study
Authors: Alqahtani Mansour M. , Willowson Kathy P. , Constable Chris , Fulton Roger , Kench Peter L. 
Published: January 2022

AbstractPurposeInvestigate the impact of acquisition time and reconstruction parameters on single‐photon emission computed tomography/computed tomography (SPECT/CT) image quality with the ultimate aim of finding the shortest possible acquisition time for clinical whole‐body SPECT/CT (WB‐SPECT/CT) while maintaining image qualityMethodsThe National Electrical Manufacturers Association (NEMA) image quality measurements were performed on a SPECT/CT imaging system using a NEMA International Electrotechnical Commission (IEC) phantom with spherical inserts of varying diameter (10–37 mm), filled with 99mTc in activity sphere‐to‐background concentration ratio of 8.5:1. A gated acquisition was acquired and binned data were summed to simulate acquisitions of 15, 8, and 3 s per projection angle. Images were reconstructed on a Hermes (HERMES Medical Solutions AB, Stockholm, Sweden) workstation using eight subsets and between 4 and 24 iterations of the three‐dimensional (3D) ordered subset expectation maximization (OSEM) algorithm. Reconstructed images were post‐smoothed with 3D Gaussian filter ranging from 0 to 12 mm full‐width at half maximum (FWHM). Contrast recovery, background variability, and contrast‐to‐noise ratio were evaluatedResultsAs expected, the spheres were more clearly defined as acquisition time and count statistics improved. The optimal iteration number and Gaussian filter were determined from the contrast recovery convergence and level of noise. Convergence of contrast recovery was observed at eight iterations while 12 iterations yielded stabilized values at all acquisition times. In addition, it was observed that applying 3D Gaussian filter of 8–12 mm FWHM suppressed the noise and mitigated Gibbs artifacts. Background variability was larger for small spheres than larger spheres and the noise decreased when acquisition time became longer. A contrast‐to‐noise ratio >5 was reached for the two smallest spheres of 10 and 13 mm at acquisition times of 8 sConclusionOptimized reconstruction parameters preserved image quality with reduce acquisition time in present study. This study suggests an optimal protocol for clinical 99mTc SPECT/CT can be reached at 8 s per projection angle, with data reconstructed using 12 iterations and eight subset of the 3D OSEM algorithm and 8 mm Gaussian post‐filter.
High incidence of amyotrophic lateral sclerosis in the Faroe Islands 2010–2020
Authors: Johansen Malan , Svenstrup Kirsten , Joensen Poul , Steig Bjarni á , Andorsdóttir Guðrið , Hansen Torben , Petersen Maria Skaalum 
Published: January 2022

AbstractThe Faroese population isolate harbors epidemiological and genetic characteristics that likely differ from outbred populations. This population‐based register study found that the Faroese 2010–2020 crude incidence of amyotrophic lateral sclerosis (ALS) was 4.9/100,000 person‐years (95% confidence interval [CI], 3.3–7.0) and the age‐ and sex‐standardized incidence (US 2010 Census Population) was 4.1/100,000 person‐years (95% CI, 2.7–6.0), which is a 68% increase from the 1987–2009 estimate. The 2020 crude prevalence was 9.5/100,000 (95% CI, 3.0–19.6) in a population of 52,912 inhabitants. Incidence and prevalence estimates of ALS in the Faroes are high and further research is warranted to uncover the genetic or environmental determinants of ALS in this population.
Nanodot‐in‐Nanofiber Structured Carbon‐Confined Sb2Se3 Crystallites for Fast and Durable Sodium Storage
Authors: Li Qinghua , Zhang Wei , Peng Jian , Yu Dandan , Liang Zhixin , Zhang Wang , Wu Jiawei , Wang Gaoyu , Li Haixia , Huang Shaoming 
Published: January 2022

AbstractAntimony‐based materials possess high specific capacity and appropriate redox potential for sodium storage, but they suffer from huge volume expansion/contraction when sodium ions insert/extract, which leads to inferior cycle life. Herein, a hierarchical nanodot‐in‐nanofiber structure is proposed to address this challenge, in which antimony selenide (Sb2Se3) nanocrystallites are confined by both 0D and 1D carbon layers. The multi‐pronged nanostructure reduces the size of active particles, alleviates the intrinsic volume change of Sb2Se3, and forms a stable transport network for charge carriers. Finally, the nanodot‐in‐nanofiber structured Sb2Se3 anode exhibits outstanding performance for sodium storage, such as high capacity and exceptional cycle lifespan for over 10 000 cycles at 2.0 A g−1. Therefore, this work can be valuable for the rational design of ultra‐stable alloy and conversion‐type materials in the application of next‐generation batteries.
Palladium‐Catalyzed Monofluoroalkylation of Aryl Iodides and Aryl Bromides with Nucleophilic Ethyl 2‐Fluoro‐2‐(trimethylsilyl)acetate
Authors: Zheng Kaiting , Liu Yaomei , Zheng Chenggong , Yan Fangpei , Xiao Hua , Feng Yi‐Si , Fan Shilu 
Published: January 2022

AbstractA palladium‐catalyzed monofluoroalkylation of aryl iodides and aryl bromides was developed using nucleophilic ethyl 2‐fluoro‐2‐(trimethylsilyl)acetate as a monofluoroalkyl source. The transformation proceeded with excellent substrate scope to afford a range of monofluoroalkylated products in good yields under mild conditions, and it proved feasible in a gram‐scale reaction. This protocol was successfully used in late‐stage modification of an estrone derivative, providing a facile route for research on the discovery of biologically active compounds and high‐performance materials.magnified image
Pyruvate Facilitates FACT‐Mediated γH2AX Loading to Chromatin and Promotes the Radiation Resistance of Glioblastoma
Authors: Wu Siyang , Cao Ruixiu , Tao Bangbao , Wu Ping , Peng Chao , Gao Hong , Liang Ji , Yang Weiwei 
Published: January 2022

AbstractDNA repair confers the resistance of tumor cells to DNA‐damaging anticancer therapies, while how reprogrammed metabolism in tumor cells contributes to such process remains poorly understood. Pyruvate kinase M2 isoform (PKM2) catalyzes the conversion of phosphoenolpyruvate to pyruvate and regulates the last rate‐limiting step of glycolysis. Here it is shown that the glycolytic metabolite pyruvate enhances DNA damage repair by facilitating chromatin loading of γH2AX, thereby promoting the radiation resistance of glioma cells. Mechanistically, PKM2 is phosphorylated at serine (S) 222 upon DNA damage and interacts with FACT complex, a histone chaperone comprising SPT16 and SSRP1 subunit. The pyruvate produced by PKM2 directly binds to SSRP1, which increases the association of FACT complex with γH2AX and subsequently facilitates FACT‐mediated chromatin loading of γH2AX, ultimately promoting DNA repair and tumor cell survival. Intriguingly, the supplementation of exogenous pyruvate can also sufficiently enhance FACT‐mediated chromatin loading of γH2AX and promotes tumor cell survival upon DNA damage. The levels of PKM2 S222 phosphorylation correlate with the malignancy and prognosis of human glioblastoma. The finding demonstrates a novel mechanism by which PKM2‐produced pyruvate promotes DNA repair by regulating γH2AX loading to chromatin and establishes a critical role of this mechanism in glioblastoma radiation resistance.
Longitudinal effects of Youth Empowerment Solutions: Preventing youth aggression and increasing prosocial behavior
Authors: Thulin Elyse J. , Lee Dan B. , Eisman Andria B. , Reischl Tom M. , Hutchison Pete , Franzen Susan , Zimmerman Marc A. 
Published: January 2022

AbstractYouth violence remains a significant public health problem despite efforts to address it. We describe the evaluation results of Youth Empowerment Solutions (YES), an after‐school active learning program implemented by trained local teachers and designed to engage middle school youth in multi‐systematic promotive behaviors at the individual‐, interpersonal‐, and community‐level to make lasting positive changes within the context of institutional disadvantages, such as racism. First, we used a modified randomized controlled trial design to examine the direct and indirect influence of YES on prosocial and delinquent behaviors 12 months after the conclusion of the program, through youth empowerment. Next, we evaluated these models by race, to determine if the intervention equitably promotes prosocial outcomes and decreases aggressive behaviors. Among 329 middle school students, YES participation enhanced prosocial behaviors through empowerment, and directly reduced aggressive behaviors a year after the conclusion of the program. This trend was particularly pronounced for African American youth. These effects were found after controlling for age, sex, and behavioral outcomes at baseline, and across different schools and teachers, suggesting that YES can also be sustainable and readily implemented by communities. The implications of the results for youth violence prevention, empowerment theory and intervention development and practice for ethnic minority youth who face structural disenfranchisement are discussed.
Electrochemical Oxidative Sulfonylation of N‐Arylamides/Amine with Sodium Sulfinates
Authors: Yu Yingliang , Fang Yang , Tang Rumeng , Xu Dongping , Dai Shuaishuai , Zhang W. 
Published: January 2022

AbstractA mild and efficient protocol for sulfonylation of 8‐aminoquinolines, naphthylamides and anilides with sodium sulfinates by anodic oxidation at room temperature was developed. In the absence of any additional catalyst and oxidant, a series of sulfonylated products were achieved in good to excellent yields. This proposal features good water tolerance, excellent selectivity and broad functional group compatibility.
Simultaneously Achieving Circular‐To‐Linear Polarization Conversion and Electromagnetically Induced Transparency by Utilizing a Metasurface
Authors: Gao Cheng‐Jing , Zhang Dan , Zhang Hai‐Feng 
Published: January 2022

AbstractIn this work, the simultaneous realization of circular‐to‐linear polarization conversion (PC) and electromagnetically induced transparency (EIT) is theoretically reported in terahertz (THz) range by utilizing a metasurface when left‐handed circularly polarized (LCP) waves are incident. The metasurface is composed of two kinds of via‐coupled modules (VCMs). Each module can realize the same EIT phenomenon by the destructive interference during the bright and dark modes due to the symmetry‐broken rotation operation of the structure instead of the near‐field coupling. The VCMs can simultaneously respond to the incident LCP waves and are identically converted into LCP and right‐handed circularly polarized (RCP) waves, which own the same amplitudes and phase shifts. Therefore, the LCP and RCP waves can generate a resultant linearly polarized (LP) wave. The EIT transparent windows have emerged in 0.729–1.051 THz during the transmission of the LCP waves and the conversion of LCP to RCP. The values of maximum group delays both are 358 ps. The operating frequency band of the PC is located in 0.65–1.10 THz, and relative bandwidth reaches 51.4%. Optimal relative conversion efficiency reaches 93.2% at 0.921 THz. The EIT behavior has been investigated by the two‐oscillator model to further confirm the consistency of the simulation results.
Systematic investigation on the swelling behaviors of acrylonitrile‐butadiene rubber via solubility parameter and Flory‐Huggins interaction parameter
Authors: Liu Susu , Jing Yuanrong , Tu Jieyun , Zou Huimin , Yong Zhanfu , Liu Guangyong 
Published: January 2022

AbstractThree‐dimensional solubility parameters (HSP) of the acrylonitrile‐butadiene rubber (NBR) were determined by combining a software program with equilibrium swelling test. Then, a modified Flory‐Huggins interaction parameter (χHSP) was calculated and compared with the traditional one (χ) in characterizing the swelling behavior of NBR. NBR exhibits quite different swelling responses in the selected seven kinds of organic solvents, which can be differentiated by the energy difference (Ra) and be further correlated with χHSP value between rubber and solvent. The results turn out that the swelling ratio (q) decreases with increasing χHSP value. By mathematical fitting, an exponential relationship between q and χHSP is achieved to predict the swelling behaviors of NBR in the increasing used bio‐fuels, bio‐diesel, and IRM903 being selected for examples. From the prediction model, we can get that there is a high swelling area for bio‐diesel/ethanol system and both a high and low swelling areas for IRM903/ethanol system. Hereby, it is expected that the swelling behavior or oil resistance of NBR based rubber parts can be predicted quantitatively in a concise way now.
Reference‐free discovery of nuclear SNPs permits accurate, sensitive identification of Carya (hickory) species and hybrids
Authors: Literman Robert A. , Ott Brittany M. , Wen Jun , Grauke L. J. , Schwartz Rachel S. , Handy Sara M. 
Published: January 2022

AbstractPremiseDNA‐based species identification is critical when morphological identification is restricted, but DNA‐based identification pipelines typically rely on the ability to compare homologous sequence data across species. Because many clades lack robust genomic resources, we present here a bioinformatics pipeline capable of generating genome‐wide single‐nucleotide polymorphism (SNP) data while circumventing the need for any reference genome or annotation data.MethodsUsing the SISRS bioinformatics pipeline, we generated de novo ortholog data for the genus Carya, isolating sites where genetic variation was restricted to a single Carya species (i.e., species‐informative SNPs). We leveraged these SNPs to identify both full‐species and hybrid Carya specimens, even at very low sequencing depths.ResultsWe identified between 46,000 and 476,000 species‐identifying SNPs for each of eight diploid Carya species, and all species identifications were concordant with the species of record. For all putative F1 hybrid specimens, both parental species were correctly identified in all cases, and more punctate patterns of introgression were detectable in more cryptic crosses.DiscussionBioinformatics pipelines that use only short‐read sequencing data provide vital new tools enabling rapid expansion of DNA identification assays for model and non‐model clades alike.
Intact fluency in autism? A comprehensive approach of verbal fluency task including word imageability and concreteness
Authors: Tóth Odett , Pesthy Orsolya , Farkas Kinga , Guttengéber Anna , Komoróczy Eszter , Réthelyi János M. , Szuromi Bálint , Németh Dezső 
Published: January 2022

AbstractVerbal fluency is a cognitive function reflecting executive functions and the ability to retrieve the appropriate information from memory quickly. Previous studies reported conflicting results—impaired and intact verbal fluency—in autism spectrum disorder (ASD). Most studies concentrate on overall word productivity, errors, perseverations, clustering, or switching. We used a comprehensive approach to evaluate the reported discrepancy in the literature and introduced a new angle using the concept of word abstraction and imageability. Moreover, we analyzed the performance in two‐time intervals (0–30 s and 31–60 s) to assess the temporal dynamics of verbal fluency and a possible activation or initiation deficit in autism. Sixteen adults with ASD and 16 neurotypical control participants, matched by gender, age, and education level, participated in our study. Contrary to our expectations, we did not find a significant difference between groups in word productivity, the number of errors, clustering, or temporal dynamics, neither in semantic nor in phonemic fluency tasks. Surprisingly, the two study groups' performance did not differ in terms of imageability or concreteness characteristics either. Our results raise the possibility that verbal fluency performance is intact in autism. We also suggest using a comprehensive approach when measuring fluency in autism.Lay summaryPeople with autism tend to think and communicate differently. In our study, we tested whether people with autism come up with more concrete or imageable words and whether their performance is better compared with neurotypicals in the beginning or in the later phase of a task measuring how many words they can produce in a minute. We did not detect any difference between the two groups; however, we recommend studying verbal fluency in autism from more and different angles in the future.