bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors influencing the prioritization of vaccines by policymakers in low- and middle-income countries: a scoping review
Authors: Guillaume Dominique , Meyer Diane , Waheed Dur-e-Nayab , Schlieff Meike , Muralidharan Kirthini , Chou Victoria B , Limaye Rupali 
Published: October 2022

Abstract
Vaccination decision making in low- and middle-income countries (LMICs) has become increasingly complex, particularly in the context of numerous competing health challenges. LMICs have to make difficult choices on which vaccines to prioritize for introduction while considering a wide range of factors such as disease burden, vaccine impact, vaccine characteristics, financing and health care infrastructures, whilst adapting to each country’s specific contexts. Our scoping review reviewed the factors that influence decision-making among policymakers for the introduction of new vaccines in LMICs. We identified the specific data points that are factored into the decision-making process for new vaccine introduction, whilst also documenting whether there have been any changes in decision-making criteria in new vaccine introduction over the last two decades. A comprehensive database search was conducted using a search strategy consisting of key terms and Medical Subject Headings (MeSH) phrases related to policy, decision-making, vaccine introduction, immunization programmes and LMICs. Articles were screened following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A total of 843 articles were identified, with 34 articles retained after abstract screening, full-text screening and grading with the mixed methods appraisal tool (MMAT). The Burchett framework for new vaccine introduction was used to identify indicators for vaccine-decision making and guided data extraction. Articles in our study represented a diverse range of perspectives and methodologies. Across articles, the importance of the disease, which included disease burden, costs of disease and political prioritization, coupled with economic factors related to vaccine price, affordability and financing were the most common criteria considered for new vaccine introduction. Our review identified two additional criteria in the decision-making process for vaccine introduction that were not included in the Burchett framework: communication and sociocultural considerations. Data from this review can support informed decision-making for vaccine introduction amongst policymakers and stakeholders in LMICs.
Reversing lysosome-ribosome circuit dysregulation mitigates C9FTD/ALS neurodegeneration and behaviors
Authors: Ma Li , Liang Chen , Wang Jing , Chang Qing , Wang Yuan , Zhang Wei , Du Yuanning , Sadan Jotham , Chen Jian-Fu 
Published: October 2022

AbstractG4C2 repeat expansion in C9orf72 causes the most common familial frontotemporal dementia and amyotrophic lateral sclerosis (C9FTD/ALS). The pathogenesis includes haploinsufficiency of C9orf72, which forms a protein complex with Smcr8, as well as G4C2 repeat-induced gain of function including toxic dipeptide repeats (DPRs). The key in vivo disease-driving mechanisms and how loss- and gain-of-function interplay remain poorly understood. Here, we identified dysregulation of a lysosome-ribosome biogenesis circuit as an early and key disease mechanism using a physiologically relevant mouse model with combined loss- and gain-of-function across the aging process. C9orf72 deficiency exacerbates FTD/ALS-like pathologies and behaviors in C9ORF72 bacterial artificial chromosome (C9-BAC) mice with G4C2 repeats under endogenous regulatory elements from patients. Single nucleus RNA sequencing (snRNA-seq) and bulk RNA-seq revealed that C9orf72 depletion disrupts lysosomes in neurons and leads to transcriptional dysregulation of ribosomal protein genes, which are likely due to the proteotoxic stress response and resemble ribosomopathy defects. Importantly, ectopic expression of C9orf72 or its partner Smcr8 in C9FTD/ALS mutant mice promotes lysosomal functions and restores ribosome biogenesis gene transcription, resulting in the mitigation of DPR accumulation, neurodegeneration as well as FTD/ALS-like motor and cognitive behaviors. Therefore, we conclude that loss- and gain-of-function crosstalk in C9FTD/ALS converges on neuronal dysregulation of a lysosome-ribosome biogenesis circuit leading to proteotoxicity, neurodegeneration and behavioral defects.
AKLHL403’ UTR splice-altering variant causes milder NEM8, an under-appreciated disease mechanism
Authors: Dofash Lein N H , Monahan Gavin V , Servián-Morilla Emilia , Rivas Eloy , Faiz Fathimath , Sullivan Patricia , Oates Emily , Clayton Joshua , Taylor Rhonda L , Davis Mark R , Beilharz Traude , Laing Nigel G , Cabrera-Serrano Macarena , Ravenscroft Gianina 
Published: October 2022

AbstractNemaline myopathy 8 (NEM8) is typically a severe autosomal recessive disorder associated with variants in the kelch-like family member 40 gene (KLHL40). Common features include fetal akinesia, fractures, contractures, dysphagia, respiratory failure and neonatal death. Here, we describe a 26-year-old man with relatively mild NEM8. He presented with hypotonia and bilateral femur fractures at birth, later developing bilateral Achilles’ contractures, scoliosis, and elbow and knee contractures. He had walking difficulties throughout childhood and became wheelchair bound from age 13 after prolonged immobilization. Muscle magnetic resonance imaging at age 13 indicated prominent fat replacement in his pelvic girdle, posterior compartments of thighs and vastus intermedius. Muscle biopsy revealed nemaline bodies and intranuclear rods. RNA sequencing and western blotting of patient skeletal muscle indicated significant reduction in KLHL40 mRNA and protein, respectively. Using gene panel screening, exome sequencing and RNA sequencing, we identified compound heterozygous variants in KLHL40; a truncating 10.9 kb deletion in trans with a likely pathogenic variant (c.*152G &gt; T) in the 3′ untranslated region (UTR). Computational tools SpliceAI and Introme predicted the c.*152G &gt; T variant created a cryptic donor splice site. RNA-seq and in vitro analyses indicated that the c.*152G &gt; T variant induces multiple de novo splicing events that likely provoke nonsense mediated decay of KLHL40 mRNA explaining the loss of mRNA expression and protein abundance in the patient. Analysis of 3’ UTR variants in ClinVar suggests variants that introduce aberrant 3’ UTR splicing may be underrecognized in Mendelian disease. We encourage consideration of this mechanism during variant curation.
Total calcium, dairy foods and risk of colorectal cancer: a prospective cohort study of younger US women
Authors: Kim Hanseul , Hur Jinhee , Wu Kana , Song Mingyang , Wang Molin , Smith-Warner Stephanie A , Zhang Xuehong , Giovannucci Edward L 
Published: October 2022

Abstract

Background
Although colorectal cancer (CRC) incidence is declining among adults aged ≥65 years, CRC incidence in younger adults has been rising. The protective role of calcium in colorectal carcinogenesis has been well established, but evidence is lacking on whether the association varies by age at diagnosis. We investigated the association between total calcium intake and risk of overall CRC and CRC before age 55 years.

Methods
In the Nurses’ Health Study II (1991–2015), 94 205 women aged 25–42 years at baseline were included in the analysis. Diet was assessed every 4 years through validated food frequency questionnaires. Multivariable-adjusted hazard ratios (HRs) and 95% CIs for CRC were estimated using the Cox proportional hazards model.

Results
We documented 349 incident CRC cases during 2 202 604 person-years of follow-up. Higher total calcium intake was associated with a reduced risk of CRC. Compared with those with &lt;750 mg/day of total calcium intake, the HR of CRC was 0.61 (95% CI, 0.38–0.97) for those who consumed ≥1500 mg/day (P for trend = 0.01). The HR per 300 mg/day increase was 0.85 (95% CI, 0.76–0.95). There was a suggestive inverse association between total calcium intake and CRC before age 55 years (HR per 300 mg/day increase, 0.87; 95% CI, 0.75–1.00), suggesting the importance of calcium intake in the younger population.

Conclusions
In a cohort of younger women, which reflects the birth cohorts, time periods and age ranges paralleling the recent rise in CRC, higher calcium intake was associated with a decreased risk of CRC.
RBP Image Database: A resource for the systematic characterization of the subcellular distribution properties of human RNA binding proteins
Authors: Benoit Bouvrette Louis Philip , Wang Xiaofeng , Boulais Jonathan , Kong Jian , Syed Easin Uddin , Blue Steven M , Zhan Lijun , Olson Sara , Stanton Rebecca , Wei Xintao , Yee Brian , Van Nostrand Eric L , Fu Xiang-Dong , Burge Christopher B , Graveley Brenton R , Yeo Gene W , Lécuyer Eric 
Published: October 2022

Abstract
RNA binding proteins (RBPs) are central regulators of gene expression implicated in all facets of RNA metabolism. As such, they play key roles in cellular physiology and disease etiology. Since different steps of post-transcriptional gene expression tend to occur in specific regions of the cell, including nuclear or cytoplasmic locations, defining the subcellular distribution properties of RBPs is an important step in assessing their potential functions. Here, we present the RBP Image Database, a resource that details the subcellular localization features of 301 RBPs in the human HepG2 and HeLa cell lines, based on the results of systematic immuno-fluorescence studies conducted using a highly validated collection of RBP antibodies and a panel of 12 markers for specific organelles and subcellular structures. The unique features of the RBP Image Database include: (i) hosting of comprehensive representative images for each RBP-marker pair, with ∼250,000 microscopy images; (ii) a manually curated controlled vocabulary of annotation terms detailing the localization features of each factor; and (iii) a user-friendly interface allowing the rapid querying of the data by target or annotation. The RBP Image Database is freely available at https://rnabiology.ircm.qc.ca/RBPImage/.
Post-transplant diabetes mellitus and renal cell cancer after renal transplantation
Authors: Porrini Esteban , Montero Nuria , Díaz Juan Manuel , Lauzurrica Ricardo , Rodríguez Juana Oramas , Torres Irene Silva , Moreso Francesc , Cruzado Josep M , Ruiz Rocío Benítez , Vilaró Meritxel Ibernon , Lima Maria Xixiang Molina , Ramchand Simran Khemlani , Ruiz Juan Carlos , Gainza de los Rios Francisco , Alvarez Carla Rodríguez , Guindo María del Carmen de Gracia , Macías Manuel , Vela David Bonet , Osuna Antonio , Bayés-Genís Beatriz , Sanchez Cristina Aleman , Ruiz María del Carmen , Rodríguez Ana Elena Rodríguez , Rollán Rosa Domínguez , Rinne Federico González , Sosa Alejandro Jiménez , Mallén Patricia Delgado , Rinne Ana González , Miranda Domingo Marrero , Torres Armando 
Published: October 2022

ABSTRACT

Background
Diabetes is a risk factor for cancer in the general population. However, few data are available on the association between post-transplant diabetes mellitus (PTDM) and cancer after transplantation.

Methods
We analyzed this issue in a Spanish cohort of patients without diabetes before transplantation. PTDM was diagnosed with consensus criteria at 12 months after transplantation and 12 months before the diagnosis of cancer. The association between PTDM and cancer (overall and specific types) was evaluated with regression analysis.

Results
During a follow-up of 12 years (interquartile range 8–14), 85 cases of 603 developed cancer (829/100 000/year) and 164 (27%) PTDM. The most frequent cancers were renal cell cancer (RCC) n = 15, 146/cases/100 000/year), lung (n = 12, 117/cases/100 000/year), colon (n = 9, 88/cases/100 000/year) and prostate (n = 9, 88/cases/100 000/year). In logistic regression, PTDM was not associated with cancer. Eight of the 164 patients with PTDM (4.9%) vs 7 of the 439 without PTDM developed RCC (1.6%) (P = .027). In multivariate analysis, PTDM was independently associated with RCC [odds ratio (OR) 2.92, confidence interval (CI) 1.03–8.27], adjusting for smoking (OR 4.020, 95% CI 1.34–12.02) and other covariates. PTDM was not associated with other types of cancer.

Conclusions
Patients with PTDM must be considered a population at risk for RCC and accordingly, the subject of active surveillance.
Towards a better understanding of arterial calcification disease progression in CKD: investigation of early pathological alterations
Authors: Van den Bergh Geoffrey , Opdebeeck Britt , Neutel Cédric , Guns Pieter-Jan , De Meyer Guido , D'Haese Patrick , Verhulst Anja 
Published: October 2022

ABSTRACT

Background
Cardiovascular disease remains the leading cause of death in chronic kidney disease (CKD) patients, especially in those undergoing dialysis and kidney transplant surgery. CKD patients are at high risk of developing arterial media calcifications (AMC) and arterial stiffness. We hypothesized that investigation of disease progression at an early stage could provide novel insights in understanding AMC etiology.

Methods
An adenine diet was administered to male Wistar rats to induce AMC. Rats were sacrificed after 2, 4 and 8 weeks. AMC was measured by assessment of aortic calcium and visualized using histology. Arterial stiffness was measured in vivo by ultrasound and ex vivo by applying cyclic stretch of physiological magnitude on isolated arterial segments, allowing us to generate the corresponding pressure–diameter loops. Further, ex vivo arterial reactivity was assessed in organ baths at 2 and 4 weeks to investigate early alterations in biomechanics/cellular functionality.

Results
CKD rats showed a time-dependent increase in aortic calcium which was confirmed on histology. Accordingly, ex vivo arterial stiffness progressively worsened. Pressure–diameter loops showed a gradual loss of arterial compliance in CKD rats. Additionally, viscoelastic properties of isolated arterial segments were altered in CKD rats. Furthermore, after 2 and 4 weeks of adenine treatment, a progressive loss in basal, nitric oxide (NO) levels was observed, which was linked to an increased vessel tonus and translates into an increasing viscous modulus.

Conclusions
Our observations indicate that AMC-related vascular alterations develop early after CKD induction prior to media calcifications being present. Preventive action, related to restoration of NO bioavailability, might combat AMC development.
Mental health and wellbeing of border security personnel: scoping review
Authors: Brooks S K , Greenberg N 
Published: October 2022

Abstract

Background
Whilst the wellbeing of law enforcement personnel has been widely researched, border security personnel as a discrete group appear to be far less discussed, despite their roles frequently exposing them to potentially traumatic and challenging events such as contact with criminals or witnessing personal tragedies due to trafficking or smuggling.

Aims
This scoping review aimed to explore existing literature to better understand the mental health of border security personnel and the factors affecting their wellbeing.

Methods
Four electronic databases and grey literature were systematically searched for studies relevant to the review’s aims. Following the extraction of relevant data from each study, thematic analysis was used to synthesize findings.

Results
Thirteen studies included relevant data and were included in the review, identifying stressors including poor management; fatigue; negative public attitudes; inadequate staffing levels, resources, and training; poor opportunities for promotion; low pay; work overload; dangerous working environments; and work-related moral dilemmas.

Conclusions
The review found that there has been little academic attention paid to border security personnel as a specific branch of law enforcement. Many of the stressors identified in this review are those also reported by law enforcement generally, although negative attitudes from the public and exposure to moral dilemmas appear to be more relevant for border security staff. Directly addressing work-related stress (e.g. by fostering a supportive organizational culture, addressing mental health stigma, and encouraging help-seeking) may be useful in enhancing the resilience of border security personnel.
A Patient With Mycobacteremia Due to Two Different Nontuberculous Mycobacteria
Authors: Hill Eddie , Wooten Darcy 
Published: October 2022

Abstract
Disseminated nontuberculous mycobacterial infections are most common in patients with severe immunosuppression, such as people with human immunodeficiency virus (HIV) and low CD4+ T-cell counts. In this report, we present a rare case of a person with HIV who was hospitalized for mycobacteremia due to 2 different nontuberculous mycobacteria. We also provide a comprehensive summary of published case reports describing nontuberculous mycobacterial coinfections.
Timbre, Technology and Hybridation in the Music of Michaël Levinas
Authors: Campbell Edward 
Published: October 2022

Abstract
This chapter discusses some key aspects of the compositional development of Michaël Levinas with reference to a significant number of his compositions, including the operas Les Nègres and La Métamorphose. Levinas studied composition with Messiaen alongside Grisey and Murail, and he was a founding member of the group L’Itinéraire in 1973. While he describes his work as having progressed in parallel with his spectral colleagues, he came to recognize his distinctive contribution to the aesthetic over time. Levinas’s composition is marked by his idiosyncratic treatment of timbre, his use of technology including loudspeakers, and his interest in hybridizing musical sounds through the placement of sound bodies in vibration with one another. Achieved at first in more rudimentary ways, Levinas developed this with great sophistication at IRCAM in the 1990s to produce what he terms “the new mixity.” The chapter concludes with an exposition of the expressive potential of Levinas’s approach to sound.
Apollodorus the Mythographer, Bibliotheca
Authors: Trzaskoma Stephen M. 
Published: October 2022

Abstract
This chapter treats Apollodorus the Mythographer (regularly referred to as Ps.-Apollodorus), the probably 1st-century ce writer who produced the Bibliotheca (Library), the most complete—although not perfectly so—and finest work of systematizing mythographer to survive from antiquity. A summary account is provided of our knowledge of the otherwise unknown author, evidence for his date, the nature of his work, his literary and intellectual ambitions, and the nature of the narrative, which gives a broad overview of Greek myth arranged chronologically from primordial times to the generation after the Trojan War. Attention is given as well to the question of Apollodorus’s sources, which has dominated modern scholarship. An account of the state of the text and how it was passed down is sketched.
Cornutus, Survey of the Traditions of Greek Theology
Authors: Ramelli Ilaria L.E. 
Published: October 2022

Abstract
This chapter concentrates on the Roman Stoic Cornutus’s mythological allegoresis in his handbook of Greek theology. For each divinity, from Ouranos to Hades, Cornutus provides an allegorical-etymological interpretation of its names and epithets, attributes, aspects of its myths and rituals, and so on. Physical allegory (Zeus represents the ether; Hera, the air, etc.) is prevalent, although there are also examples of ethical and historical exegeses. Special attention is paid to the programmatic assertion that “the ancients were not people of no account, but they were also able to understand the nature of the cosmos and had the ability to philosophise on it by means of symbols and enigmata” (35). The ancients were nothing less than philosophers, since they were endowed with the understanding of the cosmos, of what exists. What they expressed allegorically are philosophical truths. Philosophical allegoresis interprets their expressions and finds philosophical tenets therein. The chapter then shows how Cornutus was strongly influenced by Chrysippus, Apollodorus, and Crates, and how Seneca, who was no allegorizer, probably polemicized with Cornutus. Finally, it demonstrates that the Stoic allegorists of myths Cornutus and Chaeremon influenced the greatest allegorist of biblical myths, Origen.
The Mythographus Homericus
Authors: Pagès Joan 
Published: October 2022

Abstract
Mythographus Homericus (MH) is a faute de mieux denomination for a now lost handbook of mythology from the Imperial period containing a collection of historiae fabulares, that is, summaries of myths, under Homeric lemmata. Fragments on papyri from the 1st century onward demonstrate the existence of the MH. Even though this work has not been preserved as such in medieval manuscripts, many historiae presumably derived from it survives as a substantial part of the minor scholia to the Iliad and the Odyssey, the so-called D-scholia and V-scholia respectively. The MH as we know it today was a hybrid work, a hypomnema or commentary on Homer based on abstracts of mythical narratives that could be considered a handbook of mythology as well. The reasons for the gathering of all this material as Homeric scholarship are not easy to elucidate: in some cases, they enable a better understanding of the Homeric context, but they are very often a sort of glossae explaining characters, epithets, place names, aetia and foundations.
Palaephatus, Unbelievable Tales
Authors: Koning Hugo H. 
Published: October 2022

Abstract
The ancient mythographer Palaephatus’s Unbelievable Tales is a collection of well-known myths and rationalizing explanations of them. The chapter offers an analysis of a) the philosophical notions underlying Palaephatus’s project, mostly articulated in his proem, b) the rigid structure of his entries, and c) the methods he employs to reconstruct the historical truth behind the myths under investigation, all hinging on plausibility and narrative logic—it is human misunderstanding that is at the core of all mythopoesis. Although Palaephatus’s historicizing approach perhaps seems simplistic and arbitrary, it is at the same time also systematic, coherent, and consistent. Palaephatus thus occupies a unique place in the history of mythography and the exegesis of myth. References to modern scholarship provide the status quaestionis; some long-held notions are, however, significantly qualified.
Pausanias, Description of Greece
Authors: Hutton William 
Published: October 2022

Abstract
Pausanias’s Description of Greece, an eyewitness account of the cities and sanctuaries of the Greek mainland in the second century ce, is one of our richest sources for Greek myth. Although not written as a compendium of myth, Pausanias’s work always includes information about the mythological traditions associated with the places he visits. Most of this information comes from literary sources, both primary sources and compendia, but Pausanias also includes the testimony of local informants whom he encountered on his travels, and much of this local material is unattested in other sources. Whether his sources are literary, epigraphic, or oral, Pausanias presents himself as an energetic and discerning researcher on mythical matters. He considers early epic, especially the poems of Homer, as the most genuine source, approaching later sources with varying degrees of skepticism. He tends to favor rationalized versions of heroic sagas and shows a general distaste for divine myths that involve supernatural occurrences or unethical behavior on the part of the gods. He admits, however, that even incredible stories can have valid allegorical significance.