bluuebunny/crossref_metadata_2025_split huggingface dataset:
Character Building Based on Pancasila Student Profile In Private Islamic Education Institutions (MTs)
Authors: Brata Diah Puji Nali , Ningrum Tri Andini Agusti , Ilmah Siti Zurriyatul 
Published: September 2022

Pancasila Student Profile is a new policy of the Ministryof Education and Culture, which is a reference for educators in building the character and competence of students. The purpose of this study is to analyze the teacher's lesson plan related to integrating character values, to analyze the civics teacher's understanding of the Pancasila Student Profile, and to analyze the strengthening of the character of civics teachers in learning. This research method uses a qualitative approach. The subjects of the study were the head of the madrasa, civics teachers, and students. The method of data collection is the triangulation of sources and techniques. Data analysis through data reduction, data display, and data verification. The results showed that the teacher's rpp with the integration of character values showed that the preparation of the rpp was based on curriculum 13, the characteristics or conditions of the school, and the condition of the character of the students in the school; pemahaman guru about the Profile of Pelajar Pancasila has not understood and has not implemented in schools, has heard, received information from the supervisor, website , or independent literacy, and the character of the teacher in learning by the way students are taught through habituation, example, activities related to character values in order to have good character in the school, home, and community environment. Character values that are strengthened in learning include: honesty, independence, courtesy, responsibility, discipline, and religion
Immunotherapy Combined with Chemotherapy in Neoadjuvant Therapy for Locally Advanced Renal Pelvis Carcinoma: A Case Report and Literature Review
Authors: Xu Liuting , Wang Dongxing , Wu Youyou , Zhang Chunlei , Miao Pengcheng 
Published: September 2022

ABSTRACT

Introduction and importance:
Upper tract urothelial carcinoma (UTUC), including renal pelvis cancer and ureteral cancer, is highly prevalent in people aged 70 ˜ 90 years. Immune checkpoint inhibitor therapy is a major breakthrough in the field of oncology and is an emerging anti-tumor treatment modality after chemotherapy, targeted therapy and anti-angiogenic therapy. Here we presented a UTUC case who benefited from treatment of immunotherapy combined with chemotherapy in neoadjuvant therapy.

Case presentation:
A 66-year-old male patient presented on July 2, 2021, with a 3-month history of left-sided abdominal pain and a 2-month history of gross hematuria. To confirm the diagnosis, the treatment of left ureteroscopy was performed under general anesthesia on July 7, 2021. Biopsy pathology revealed urothelial carcinoma, clinical stage cT3-4N1M0, high-risk. Four cycles of neoadjuvant therapy were preoperatively administered with immunotherapy combined with chemotherapy every 21 days. Partial response (PR) was confirmed via imaging after the 4th cycle. The patient underwent radical surgery on November 11, 2021. Postoperative diagnosis: left renal pelvis cancer, pT3N0M0, high risk. Adjuvant therapy was continued after surgery with 4 cycles of GC chemotherapy. After chemotherapy, CTU reexamination and cystoscopy was performed and show no signs of the carcinoma returning.

Discussion:
Immune checkpoint inhibitors have become first-line therapy for patients with metastatic UC who are not candidates for cisplatin chemotherapy. However, the current literature is inconclusive on the efficacy of neoadjuvant therapy with preoperative immunotherapy combined with chemotherapy. We discuss clinical outcomes and literature reviews for these patients.

Conclusion:
It’s feasible and safe in PD-L1-positive locally advanced UTUC patients that preoperative neoadjuvant PD-1 inhibitor immunotherapy combined with GC chemotherapy was selected for 4 cycles, after neoadjuvant therapy, further radical surgery was performed, and adjuvant chemotherapy was performed after surgery.

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Kopeck Journalism as a Social Profession: Upward Mobility, Service, and the Civil Society Spectrum in Late Imperial Russia
Authors: Cowan Felix 
Published: September 2022

Abstract
Through case studies of five prominent journalists, editors, and publishers, this article explores journalism at late imperial Russia’s kopeck newspapers. Exploring the lives and careers of journalists from wide-ranging backgrounds who shared a view of their work as both a business and a form of service to poor Russians, this article argues that kopeck journalists thought their profession combined entrepreneurship and upward mobility with activism and civic responsibility. The life stories and views of kopeck journalists reveal that civil society was not limited to small groups of educated middle-class Russians but rather included a wide range of actors and initiatives. Viewing these figures as members of late imperial Russian civil society also demonstrates that civil society activity could coexist with business concerns and operate within Russia’s emerging free market, despite the critiques of contemporary observers who saw commercial and social goals as inherently contradictory.
Penanaman Nilai-Nilai Karakter Anak Usia Dini di Wilayah Sekitar Candi Borobudur
Authors: Khalimah Ema , Prasetyo Iis 
Published: September 2022

Candi Borobudur terletak di Kecamatan Borobudur Kabupaten Magelang. Keberadaan candi Borobudur telah memberikan pengaruh bagi masyarakat sekitar candi Borobudur dalam banyak hal, termasuk bagi orang tua dalam menanamkan karakter pada anak usia dini. Penelitian ini bertujuan untuk mendeskripsikan gambaran penanaman nilai-nilai karakter terhadap anak usia dini di wilayah sekitar candi Borobudur. Jenis penelitian ini adalah kualitatif deskriptif. Teknik pengumpulan data adalah dengan observasi, wawancara dan dokumentsi. Beberapa pertanyaan kepada orang tua dilakukan dengan menggunakan google form. Analisis data kualitatif melalui pengumpulan data, reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa kekhasan wilayah Borobudur telah memberikan arah pandang orang tua dalam menanamkan nilai karakter bagi anak usia dini seperti rasa toleransi beragama, ramah, peduli, jujur, suka menolong, peka terhadap orang lain, menanamkan sikap menjaga warisan kuno, melestarikan budaya, menanamkan jiwa wirausaha, kreatif, inovatif, dan gigih, kerjasama, dan menanamkan nilai seni.
Pollen storage, viability and effect of growth hormones on in vitro pollen germination in two medicinal plants (Clerodendrum colebrookianum Walp. and Clerodendrum infortunatum L.) of the tropical moist forest of North-east India
Authors: Singh Puyam Devanda , Kumar Kewat Sanjay , Khanduri Vinod Prasad 
Published: September 2022

Clerodendrum colebrookianum Walp. and Clerodendrum infortunatum L. are well known for their medicinal uses in treating various human ailments traditionally. Pollen biology study was done in both plant species to decipher pollen viability, in vitro pollen germination, and pollen storage in varied temperature conditions. Pollen viability tests was done by 2, 3, 5-triphenyl tetrazolium chloride (TTC test) for which pollen grains were collected at the anthesis stage that ascertained high viability, ranged between 71.97%±4.30 % in C. colebrookianum and 81.63%±3.23 in C. infortunatum. In vitro pollen germination was conducted under different hormones (IBA, IAA, GA3, and Kinetin) with concentrations of 100 mg L-1, 200 mg L-1 and 300 mg L-1. Highest germination percentage of 52.10±5.30% and 61.91±1.76% in GA3 (200 mg L-1) was the most suitable growth hormone concentration for inducing in vitro pollen germination in both Clerodendrum species. Statistically, the response of all the concentrations of treatments, sucrose, and hormones, with their time on in vitro pollen germination of C. colebrookianum and C. infortunatum was found significantly different (p<0.05). In contrast, non-significant differences were recorded for in vitro pollen germination between the medicinal plant species. Pollen storage under temperature gradient conditions exhibited a similar trend in the viability for both C. colebrookianum, and C. infortunatum, i.e., the pollen remained viable up to 28 days at -20°C and 6°C, respectively. This study will be helpful in future breeding, hybridization, and conservation efforts for both the Clerodendrum species.
Evaluación de la escala Status Epilepticus Severity Score (STESS) como predictor de la mortalidad intrahospitalaria en pacientes con estado: Estudio observacional retrospectivo
Authors: Vidal-Mayo José de Jesús , Guzmán Ramírez Uriel , Hernández-Gilsoul Thierry , Kammar-García Ashuin , Pérez Méndez Ayari , Mancilla-Galindo Javier 
Published: September 2022

Antecedentes. El estado epiléptico (EE) es una emergencia médica caracterizada por actividad epiléptica continua o recurrente con una alta mortalidad. La escala STESS (Status Epilepticus Severity Score) permite evaluar el pronóstico de pacientes con EE.
Objetivo. Describir las características clínicas de los pacientes con EE en nuestro centro, determinar las variables asociadas a mortalidad y determinar la capacidad predictora de la escala STESS para mortalidad intrahospitalaria.
Material y métodos. Estudio de cohorte retrospectivo. Se incluyeron pacientes con diagnóstico de EE durante el periodo de 2000-2020. Se aplicó la escala pronóstica STESS a todos los pacientes. Se obtuvieron datos de las características clínicas y mortalidad intrahospitalaria. Se aplicó un análisis de regresión de Cox para determinar el riesgo de mortalidad por cada punto de la escala STESS, y se calculó el área bajo la curva ROC para determinar la capacidad de discriminación de la escala.
Resultados. Fueron incluidos 60 pacientes. La presentación clínica predominante fue el EE convulsivo generalizado en 51.7%, las etiologías más frecuentes fueron sintomáticas agudas (46.7%). La mortalidad hospitalaria fue 40%. El riesgo de mortalidad se incrementa un 38% por cada punto de STESS (B=0.38, HR=1.48, IC95%:1.13-1.94, p=0.005). El área bajo la curva ROC de la escala STESS fue 0.72 con un punto de corte óptimo ≥3 puntos para discriminación de mortalidad hospitalaria.
Conclusiones. La escala STESS se asocia significativamente con la mortalidad intrahospitalaria y puede ser usada como predictor de los desenlaces adversos en pacientes con EE.
Paris’te Yunan Propagandası 1919-1920
Authors: ÖZGÖREN Aydın 
Published: September 2022

I. Dünya Savaşı Büyük Yunanistan fikrini gerçekleştirebilmek için Yunanistan’a önemli fırsatlar bahşediyordu. Savaşa dahil olma konusunda çekimser kalan Yunan Kralı ile yaşanan mücadeleyi kazanan Yunan Başbakanı Eleftherios Venizelos ülkesini Büyük Britanya ve Fransa’nın yer aldığı müttefikler yanında savaşa dahil etmiştir.
Savaşta müttefik devletlerin yanında yer almasından dolayı savaşın sonunda elde edilen başarıdan pay almak için Venizelos ülkesi adına diplomatik bir seferberlik ilan etmiştir. Venizelos, Büyük Yunanistan’ın gerçekleştirilmesi için Yunanistan adına taleplerini 18 Ocak 1919 tarihinde Paris’te açılan Paris Sulh Konferans’ında dile getirmiştir.
Bu süreçte Venizelos’un önünde taleplerinin haklılığı konusunda ikna edilmesi gereken bir Batı kamuoyu bulunuyordu. Diğer yandan Konferans başlamadan önce Büyük Britanya ve Fransa’nın desteğini kazanmış olmasına rağmen Venizelos’un Konferans’ta Yüksek Konsey’in üyelerinden biri olan Amerika Birleşik Devletleri Başkanı Wilson’u da ikna etmesi gerekiyordu. Ayrıca bu dönemde Büyük Güçlerin Savaş öncesinde ve Savaş sırasında İtalya’ya söz verilen topraklar üzerinde Yunanların hak iddia etmesinden dolayı yaşanan tartışmalardan Venizelos’un haklı çıkması gerekmekteydi.
Makalede I. Dünya Savaşı sonrasında barış şartlarını görüşmek amacıyla 18 Ocak 1919’da açılmış olan Paris Sulh Konferansı sürecinde Yunan Babakanı Eleftherios Venizelos öncülüğünde yürütülen Yunan propagandası ele alınacaktır.
Bu kapsamda yayımlanan kitap ve broşürler, düzenlenen sergi ve toplantılar, yapılan görüşmeler ve düzenlenen konferanslar ele alınarak Yunanların Paris’te kendi lehlerine nasıl bir kamuoyu oluşturdukları anlaşılmaya çalışılacaktır. Makalede ayrıca Venizelos’un Paris Sulh Konferansı’nda Yunanistan için yaptığı taleplerin bir propaganda faaliyeti kapsamında Fransız basını aracılığı ile kamuoyuna nasıl tanıtıldığı ele alınacaktır.
Підвищення безпеки ядерної енергетики з урахуванням уроків важких аварій
Authors: Kondratyuk V. , Pysmennyy Y. , Verinov O. , Filatov V. , Ostapenko I. 
Published: September 2022

Уроки відомих важких (ядерних) аварій визначають необхідність подальшого підвищення безпеки ядерних енергоустановок. У напрямах кваліфікації та модернізації систем управління аваріями це насамперед стосується модернізації системи аварійного електропостачання і модернізації пасивних систем безпеки для подолання аварій з повним тривалим знеструмленням енергоблоків, систем пасивного відведення тепла. Важливим напрямом є зменшення обмежень застосування імовірнісних та детерміністичних методів об'єктивної оцінки рівня безпеки є покращення та розробка сучасних експлуатаційних інструкцій / керівництв управління аваріями із відносно малоймовірними подіями, що мають катастрофічні наслідки. Основні обмеження застосування імовірнісних методів аналізу безпеки пов'язані з недостатньою обґрунтованістю ймовірнісних критеріїв та параметрів безпеки. Основні обмеження застосування відомих детерміністичних методів аналізу безпеки пов'язані з недостатньою фізичною обґрунтованістю окремих параметрів математичних моделей розрахункових кодів, а також ефектами розходження кодів та користувачів. Під час моделювання аварій загалом необхідно враховувати критерії безпеки, встановлені по відношенню до ядерного палива, оболонок ТВЕЛ, умови виникнення парових вибухів та різних видів теплогідродинамічної нестійкості.
PENGARUH PENERAPAN STANDAR AKUNTANSI PEMERINTAH, KOMPETENSI SUMBER DAYA MANUSIA, PERAN AUDIT INTERNAL TERHADAP KUALITAS LAPORAN KEUANGAN PEMERINTAH DAERAH (Studi Pada OPD Kabupaten Sukoharjo)
Authors: Handayani Putri Nur , Rispantyo Rispantyo , Sunarti Sunarti 
Published: September 2022

This study aims to determine the effect of application of government accounting standards on quality of region’s government financial reports, the effect of human resource competencies on quality of regions’s government financial reports, the effect of the role of internal audit on quality of regin’s government financial reports, and to determine the effect of the application of government accounting standards, human resources, the role of internal audits on the quality of region’s government financial reports.
This study belongs to quantitative research. The sample was determined by purposive sampling technique used 161 sample. Data analysis was done by using multiple regression with the help of SPSS V21 software.
The results showed that the application of government accounting standards had a positive and significant effect on the quality of region’s government financial report, human resource competence had a positive and significant effect on the quality of region’s government financial reports, the role of internal audit had a positive and significant effect on the quality of region’s government financial reports, and the application of government accounting standards, human resource competencies, the role of internal audit had a significant effect on the quality of region’s government financial reports.
The ethical responsibility to continue investigational treatments of research participants in situation of armed conflicts, economic sanctions or natural catastrophes
Authors: Kerpel-Fronius Sandor , Kurihara Chieko , Crawley Francis P. , Baroutsou Varvara , Becker Sander , Franke-Bray Brigitte , Matsuyama Kotone , Naseem Shehla , Schenk Johanna 
Published: September 2022

This paper discusses the effects of armed conflict, economic sanctions, and natural catastrophes on ongoing clinical trials. We suggest that• stopping the accrual of new patients in clinical trials under such extreme conditions is acceptable.• research participants already receiving trial medication in such disruptive situations are to be considered highly vulnerable due to their medical dependency for ongoing treatment according to the approved clinical study protocol.• based on the present experience in Ukraine and Russia, we conclude that finishing ongoing trial treatments according to approved or amended protocols should be considered to be an ethical obligation of trial sponsors irrespective whether trial disruption is due to war, economic sanctions, or natural catastrophes.• it is important to devote more attention to the ethical challenges raised by such fundamentally disruptive situations to clinical trials generally in any region of the world.
Impact of SARS-CoV-2-specific memory B cells on the immune response after mRNA-based Comirnaty vaccine in seronegative health care workers
Authors: Vallejo Alejandro , Vizcarra Pilar , Martín-Hondarza Adrián , Gómez-Maldonado Sandra , Haemmerle Johannes , Velasco Héctor , Casado José L. 
Published: September 2022

PurposeTo analyze the impact of SARS-COV-2-specific memory B cells (MBC) on the immune response after two doses of mRNA-based Comirnaty COVID-19 vaccine in seronegative health care workers. This study is seeking a rationale for boosting vaccines.MethodsLongitudinal study including 31 seronegative health care workers with undetectable specific MBCs (IgG−MBC− group), 24 seronegative with detectable specific MBCs (IgG−MBC+ group), and 24 seropositive with detectable specific MBCs (IgG+MBC+ group). The level of antibodies that inhibit ACE2-RBD interaction, and anti-Spike IgG, IgA, and IgM antibodies was quantified by ELISA. In addition, specific memory B and T cells were quantified by flow cytometry.ResultsThe level of specific MBCs, and isotypes, in the IgG−MBC− group was lower compared to that found in IgG−MBC+ (p = 0.0001) and IgG+MBC+ (p &lt; 0.0001) groups, respectively. ACE2-RBD neutralizing antibodies and anti-S IgG antibodies were at lower levels in the IgG−MBC−group after the vaccine. Specific MBCs directly correlated with specific CD4+ T cells (although not significant, p = 0.065), while no correlation was found with specific CD8+ T cells (p = 0.156) after the vaccine. In parallel, ACE2-RBD neutralizing antibodies only positively correlated with specific CD4+ T cells (p = 0.034).ConclusionIgG−MBC− individuals showed the worst humoral and cellular responses, both in frequency and magnitude, after vaccination. Individuals whose antibodies wane and become undetectable after a given period of time post vaccination and show no specific MBCs are less protected and hence are good candidates for boosting vaccine. On the other hand, seronegative individuals with specific MBC showed faster and higher responses compared to the IgG−MBC− group.
Risk of infection in roxadustat treatment for anemia in patients with chronic kidney disease: A systematic review with meta-analysis and trial sequential analysis
Authors: Chong Shan , Xie Qiufen , Ma Tiantian , Xiang Qian , Zhou Ying , Cui Yimin 
Published: September 2022

Background: Many studies demonstrated that roxadustat (FG-4592) could increase hemoglobin (Hb) levels effectively in anemia patients with chronic kidney disease (CKD). However, its safety remains controversial. This study aims to explore the risk of infection for CKD patients treated with roxadustat, especially focused on sepsis.Methods: We thoroughly searched for the randomized controlled trials (RCTs) comparing treatment with roxadustat versus erythropoiesis stimulating agents (ESAs) or placebo in PubMed, Embase, Cochrane Library, ClinicalTrials.gov, European Union Clinical Trials Register. Both on and not on dialysis anemia patients with CKD were included. Primary outcomes contained the incidence rates of sepsis. Secondary outcomes included infection-related consequences (septic shock and other infection events), general safety outcomes [all-cause mortality, treatment-emergent adverse events (TEAEs) and treatment-emergent serious adverse events (TESAEs)] and iron parameters. Moreover, a trial sequential analysis (TSA) was conducted to assess if the results were supposed to be a robust conclusion.Results: Eighteen RCTs (n = 11,305) were included. Overall, the incidence of sepsis (RR: 2.42, 95% CI [1.50, 3.89], p = 0.0003) and cellulitis (RR: 2.07, 95% CI [1.24, 3.44], p = 0.005) were increased in the roxadustat group compared with placebo group. In non-dialysis-dependent (NDD) CKD patients, the incidence of cellulitis (RR 2.01, 95% CI [1.23, 3.28], p = 0.005) was significantly higher in roxadustat group than that in the ESAs or placebo group. Both groups showed similar results in the incidence of septic shock (RR 1.29, 95% CI [0.86, 1.94], p = 0.22). A significant increased risk of all-cause mortality [risk ratios (RR): 1.15, 95% confidence interval (CI) [1.05, 1.26], p = 0.002] was found in roxadustat treatment, and TSA confirmed the result. Compared with ESAs or placebo, both the incident rates of TEAEs (RR:1.03, 95% CI [1.01, 1.04], p = 0.008) and TESAEs (RR: 1.06, 95% CI [1.02, 1.11], p = 0.002) were significantly increased in roxadustat group. As for iron parameters, changes from baseline (Δ) of hepcidin (MD: -26.46, 95% CI [-39.83, -13.09], p = 0.0001), Δ ferritin and Δ TSAT were remarkably lower in the roxadustat group, while Δ Hb, Δ iron and Δ TIBC increased significantly versus those in ESAs or placebo group.Conclusion: We found evidence that incidence rates of sepsis and cellulitis are higher in roxadustat group compared with placebo. This may be the result of improved iron homeostasis. The risk of all-cause mortality, TEAEs and TESAEs in CKD patients also increased in patients treated with roxadustat. We need more clinical and mechanistic studies to confirm whether roxadustat really causes infection.
Analysis between preoperative cervical radiographic parameters represented by the K-line tilt and the short-term prognosis of laminoplasty for posterior longitudinal ligament ossification: A retrospective study
Authors: Wei Baixing , Liu Wanting , Wu Han 
Published: September 2022

ObjectivesTo investigate the relationship between preoperative radiographic parameters and the short-term prognosis of patients with cervical ossification of the posterior longitudinal ligament (OPLL) who underwent laminoplasty (LAMP).MethodsA retrospective analysis of Cervical OPLL 50 patients with K-line (+) OPLL with no cervical kyphosis who received LAMP was performed. Based on preoperative neutral position x-ray, the K-line tilt, C2–C7 SVA (sagittal vertical axis), CL (cervical lordosis), T1 slope, and T1 slope-CL were recorded. The JOA (Japanese orthopaedic association scores) score and the cervical kyphosis change were recorded 1 year after surgery. Patients were divided into good and poor prognosis groups according to the median (12.5) of the postoperative JOA score.ResultsThere were differences between the two groups in K-line tilt, C2–C7 SVA, and T1 slope (all ps &lt; 0.05). There was a strong linear correlation between the three, K-Line tilt, JOA score, and C2–C7 SVA. The degree of influence of K-line tilt, C2–C7 SVA, T1 slope on postoperative JOA score was analyzed using multiple linear regression, and the absolute value of the standardized coefficient Beta were 0.550, 0.319, 0.185, respectively. There was no cervical kyphosis change 1 year after surgery.ConclusionAs preoperative cervical parameters, the influence of K-line tilt, C2–C7 SVA, and T1 slope on postoperative JOA score decreases in order. There was a linear relationship between preoperative K-line tilt and postoperative JOA score, implying that patients with cervical OPLL with high K-line tilt were not eligible for LAMP. K-line tilt was not predictive of cervical kyphosis change after LAMP in patients with OPLL at short-term follow-up.