bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological factors associated with foot and ankle pain: a mixed methods systematic review
Authors: Cotchett Matthew , Frescos Nicoletta , Whittaker Glen A. , Bonanno Daniel R. 
Published: February 2022

AbstractBackgroundFoot and ankle pain is common, and generally viewed through a biomedical lens rather than applying a biopsychosocial model. The objectives of this review were to evaluate: (1) the psychosocial characteristics of participants with foot/ankle pain compared to participants without foot/ankle pain; (2) the association between psychosocial factors with pain and function in people with foot/ankle pain; and (3) understand the psychosocial factors associated with the lived experience of foot/ankle pain.MethodsA mixed methods systematic review was conducted according to the PRISMA guidelines and guided by the Joanna Briggs Institute methodology for mixed methods systematic reviews. The databases MEDLINE, Embase, CINAHL, SPORTDiscus, PsychInfo, and Scopus were searched. The Mixed Methods Assessment Tool was used to evaluate study quality. A convergent segregated approach was used to synthesise and integrate quantitative and qualitative data.ResultsEighteen studies were included, consisting of 13 quantitative, 4 qualitative and 1 mixed methods study. The overall quality of the studies was considered high. Integration of the quantitative and qualitative data were not possible due to the disparate nature of the included studies. A narrative synthesis of the quantitative data revealed that negative emotional and cognitive factors were more common in people with foot/ankle pain compared to those without foot/ankle pain. A significant association was also found between emotional distress with foot pain and foot function in some people with plantar heel pain. In addition, kinesiophobia and pain catastrophising were significantly associated with impaired foot function, and pain catastrophising was significantly associated with first step pain in people with plantar heel pain. The qualitative data revealed emotional impacts, physical challenges, and a loss of self which was individual and unpredictable.ConclusionsThis review provides evidence that negative psychological constructs are greater in participants with foot/ankle pain compared to those without foot/ankle pain, although the cross‐sectional nature of the study designs included in this review reduces the certainty of the evidence. These findings indicate that psychological constructs are associated with foot/ankle pain. Further research should evaluate the predictive ability of multidimensional screening tools to identify patients at risk of developing persistent foot/ankle pain.
Stage IA1 HPV-associated cervical squamous cell carcinoma metastasizing to ovary by special pathway: a case report and literature review
Authors: Zhang Yuanyuan , Zhang Xiaobo , Wang Huan , Shen Danhua 
Published: February 2022

Abstract
Background
As the leading cancer of the female reproductive tract, it is not uncommon for human papilloma virus (HPV)-associated cervical squamous cell carcinoma (HPV-CSCC) to metastasize to pelvic organs and lymph nodes in advanced stages. However, herein, we present a rare case in which superficial invasive HPV-CSCC metastasized to the unilateral ovary as a large mass by spreading directly through the endometrium and fallopian tubes and lymph-vascular space invasion. The case is so unexpected that the misdiagnosis most likely could be proceeded as a primary ovarian cancer.

Case presentation
A 58-year-old postmenopausal woman presented vaginal bleeding for more than 4 months, never received hormonal treatment and had no family history of malignant diseases. Routine ultrasound revealed a 12 × 10 × 10 cm right ovarian mass. Intraoperative frozen section was diagnosed as a borderline Brenner tumour with local highly suspected invasive carcinoma. Accordingly, omentectomy surgery then occurred. Unbelievably, by observation under a microscope, immunohistochemistrial staining, and HPV RNA scope, we found that the carcinoma originated from the uterine cervix. In the uterine cervix, stage IA1 superficial invasive squamous carcinoma was found, and the carcinoma directly spread to the endometrium and bilateral fallopian tube, was planted into the right ovary and eventually grew as a large mass. Moreover, lymph-vascular space invasion (LVSI) was also discovered. To date, the patient has been given 6 cycles of chemotherapy and has experienced no recurrence.

Conclusions
The diagnosis of superficial invasive cervical squamous cell carcinoma metastasizing to the ovary is very challenging for pathological doctors, especially in intraoperative consultations.
Detection of plasma Aβ seeding activity by a newly developed analyzer for diagnosis of Alzheimer’s disease
Authors: Jia Jianping , Li Tingting , Yang Jianwei , Chen Baian , Qin Wei , Wei Cuibai , Song Yang , Wang Qigeng , Li Yan , Jia Longfei 
Published: February 2022

Abstract
Objective
To evaluate the diagnostic value of plasma β-amyloid (Aβ) seeding activity measured using a newly developed instrument to distinguish Alzheimer’s disease (AD) from other forms of dementia.

Methods
Seventy-nine AD patients, 64 non-AD dementia (NADD) patients, and 75 cognitively normal (NC) subjects were recruited in the study. To measure the levels of Aβ seeding activity in the plasma samples, we have developed an AD-seeds protein analyzer. We used receiver operating characteristic (ROC) curves to quantify the ability of plasma Aβ seeding activity to distinguish between AD and NADD or NC individuals. Spearman’s correlation was used to examine the associations between plasma Aβ seeding activity and global cognitive function or conventional AD biomarkers.

Results
The Aβ seeding activities were 0.83 (0.58–1.16) A.U. in AD, 0.42 (0.04–0.74) A.U. in NADD and 0.42 (0.09–0.69) A.U. in NC, respectively. The Aβ seeding activity was able to identify AD patients and distinguish them from NC or NADD with high accuracy (AUC = 0.85–0.86). In addition, the plasma Aβ seeding activity showed a strong correlation with cognitive performance (mini-mental state examination, r = − 0.188; Montreal cognitive assessment, r = − 0.189; clinical dementia rating, r = 0.205) and conventional biomarkers (cerebrospinal fluid [CSF] Aβ42/40, r = -0.227; CSF T-tau/Aβ42, r = 0.239; CSF P-tau/Aβ42, r = 0.259).

Conclusion
Our results confirmed that plasma Aβ seeding activity is an antibody-free and low-cost biomarker for the diagnosis of AD.

Trial registration
Trial registration number NCT04850053
Dimethyl fumarate decreases short-term but not long-term inflammation in a focal EAE model of neuroinflammation
Authors: Vainio S. K. , Dickens A. M. , Matilainen M. , López-Picón F. R. , Aarnio R. , Eskola O. , Solin O. , Anthony D. C. , Rinne J. O. , Airas L. , Haaparanta-Solin M. 
Published: February 2022

Abstract
Background
Dimethyl fumarate (DMF) is an oral immunomodulatory drug used in the treatment of autoimmune diseases. Here, we sought to study whether the effect of DMF can be detected using positron emission tomography (PET) targeting the 18-kDa translocator protein (TSPO) in the focal delayed-type hypersensitivity rat model of multiple sclerosis (fDTH-EAE). The rats were treated orally twice daily from lesion activation (day 0) with either vehicle (tap water with 0.08% Methocel, 200 µL; control group n = 4 (3 after week four)) or 15 mg/kg DMF (n = 4) in 0.08% aqueous Methocel (200 µL) for 8 weeks. The animals were imaged by PET using the TSPO tracer [18F]GE-180 in weeks 0, 1, 2, 4, 8, and 18 following lesion activation, and the non-displaceable binding potential (BPND) was calculated. Immunohistochemical staining for Iba1, CD4, and CD8 was performed in week 18, and in separate cohorts of animals, following 2 or 4 weeks of treatment.

Results
Using the fDTH-EAE model, DMF reduced the [18F]GE-180 BPND in the DMF-treated animals compared to control animals after 1 week of treatment (two-tailed unpaired t test, p = 0.031), but not in weeks 2, 4, 8, or 18 when imaged in vivo by PET. Immunostaining for Iba1 showed that DMF had no effect on the perilesional volume or the core lesion volume after 2 or 4 weeks of treatment, or at 18 weeks. However, the optical density (OD) measurements of CD4+ staining showed reduced OD in the lesions of the treated rats.

Conclusions
DMF reduced the microglial activation in the fDTH-EAE model after 1 week of treatment, as detected by PET imaging of the TSPO ligand [18F]GE-180. However, over an extended time course, reduced microglial activation was not observed using [18F]GE-180 or by immunohistochemistry for Iba1+ microglia/macrophages. Additionally, DMF did affect the infiltration of CD4+ and CD8+ T-lymphocytes at the fDTH-EAE lesion.
A glycolysis-related two-gene risk model that can effectively predict the prognosis of patients with rectal cancer
Authors: Liu Zhenzhen , Liu Zhentao , Zhou Xin , Lu Yongqu , Yao Yanhong , Wang Wendong , Lu Siyi , Wang Bingyan , Li Fei , Fu Wei 
Published: February 2022

Abstract
Background
Aerobic glycolysis is an emerging hallmark of cancer. Although some studies have constructed glycolysis-related prognostic models of colon adenocarcinoma (COAD) based on The Cancer Genome Atlas (TCGA) database, whether the COAD glycolysis-related prognostic model is appropriate for distinguishing the prognosis of rectal adenocarcinoma (READ) patients remains unknown. Exploring critical and specific glycolytic genes related to READ prognosis may help us discover new potential therapeutic targets for READ patients.

Results
Three gene sets, HALLMARK_GLYCOLYSIS, REACTOME_GLYCOLYSIS and REACTOME_REGULATION_OF_GLYCOLYSIS_BY_FRUCTOSE_2_6_BISPHOSPHATE_METABOLISM, were both significantly enriched in both COAD and READ through glycolysis-related gene set enrichment analysis (GSEA). We found that six genes (ANKZF1, STC2, SUCLG2P2, P4HA1, GPC1 and PCK1) were independent prognostic genes in COAD, while TSTA3 and PKP2 were independent prognostic genes in READ. Glycolysis-related prognostic model of COAD and READ was, respectively, constructed and assessed in COAD and READ. We found that the glycolysis-related prognostic model of COAD was not appropriate for READ, while glycolysis-related prognostic model of READ was more appropriate for READ than for COAD. PCA and t-SNE analysis confirmed that READ patients in two groups (high and low risk score groups) were distributed in discrete directions based on the glycolysis-related prognostic model of READ. We found that this model was an independent prognostic indicator through multivariate Cox analysis, and it still showed robust effectiveness in different age, gender, M stage, and TNM stage. A nomogram combining the risk model of READ with clinicopathological characteristics was established to provide oncologists with a practical tool to evaluate the rectal cancer outcomes. GO enrichment and KEGG analyses confirmed that differentially expressed genes (DEGs) were enriched in several glycolysis-related molecular functions or pathways based on glycolysis-related prognostic model of READ.

Conclusions
We found that a glycolysis-related prognostic model of COAD was not appropriate for READ, and we established a novel glycolysis-related two-gene risk model to effectively predict the prognosis of rectal cancer patients.
A novel LARGE1-AFF2 fusion expanding the molecular alterations associated with the methylation class of neuroepithelial tumors with PATZ1 fusions
Authors: Tauziède-Espariat Arnault , Chotard Guillaume , le Loarer François , Baud Jessica , Azmani Rihab , Dangouloff-Ros Volodia , Boddaert Nathalie , Icher-de-Bouyn Céline , Gimbert Edouard , Hasty Lauren , Métais Alice , Chrétien Fabrice , Varlet Pascale ,   on behalf of the the RENOCLIP-LOC
Published: February 2022

AbstractA novel DNA methylation class of tumor within the central nervous system, the "neuroepithelial tumor (NET),PATZ1fusion-positive” has recently been identified in the literature, characterized byEWSR1- andMN1-PATZ1fusions. The cellular origin of this tumor type remains unknown, wavering between glioneuronal or mesenchymal (as round cell sarcomas withEWSR1-PATZ1of the soft tissue). Because of the low number of reported cases, this tumor type will not be added to the 2021 World Health Organization Classification of Tumors of the Central Nervous System (CNS). Herein, we report one case of a CNS tumor classified by DNA methylation analysis as NET-PATZ1but harboring a novelLARGE1-AFF2fusion which has until now never been described in soft tissue or the CNS.We compare its clinical, histopathological, immunophenotypical, and genetic features with those previously described in NET-PATZ1. Interestingly, the current case presented histopathological (astroblastoma-like features, glioneuronal phenotype), clinical (with a favorable course), genetic (1p loss), and epigenetic (DNA-methylation profiling) similarities to previously reported cases of NET-PATZ1. Our results added data suggesting that different histomolecular tumor subtypes seem to be included within the methylation class “NET,PATZ1fusion-positive”, including nonPATZ1fusions, and that further cases are needed to better characterize them.
Latitudinal and interhemispheric differences of the ionospheric semi-diurnal lunitidal perturbations during the 2009 Arctic sudden stratospheric warming event in the eastern Asia–Australia sector
Authors: Liu Jing , Zhang Donghe , Sun Shuji , Hao Yongqiang , Xiao Zuo 
Published: February 2022

AbstractThe ionosphere exhibits some characteristic perturbations during sudden stratospheric warming (SSW) events, of which the mechanism is not thoroughly understood. This study focuses on the latitudinal and interhemispheric differences of the enhanced semi-diurnal lunitidal (M2) perturbations related to SSW using total electron content calculated from the network of Global Navigation Satellite System and ionosonde data in the eastern Asia–Australia sector during the January 2009 SSW. Our results show that the most distinct M2 perturbations in the northern and southern hemispheres occur near the Equatorial Ionization Anomaly crest regions around ± 15° geomagnetic latitudes, but corresponds to different moon phases, respectively. Clear M2 perturbations extend to middle latitudes only in the southern hemisphere and have another local maximum in the southern middle latitude. Such latitudinal and interhemispheric features of ionospheric M2 perturbations in the low latitude in the eastern Asia–Australia sector are similar as those in the American sector during the same SSW event. This supports previous suggestion that such latitudinal and interhemispheric differences in the low latitude can be primarily explained by the summer–winter thermospheric wind modulation on equatorial plasma fountain and thus emphasize its role in the vertical coupling process of M2 perturbation. The clear differences of M2 perturbations in the southern middle latitude between the eastern Asia–Australia and American sectors indicate that the thermospheric circulation related to the Weddell Sea Anomaly may have influence on the lower atmosphere–ionosphere coupling.
Graphical Abstract
Wasting and associated factors among critically ill children admitted to pediatric intensive care unit in Ethiopia
Authors: Teshager Nahom Worku , Amare Ashenafi Tazebew , Tamirat Koku Sisay , Zemene Melkamu Aderajew 
Published: February 2022

AbstractBackgroundNutritional problems are increasingly associated with acute infections. It is also related to further complications of illnesses and poor treatment outcomes of medical conditions. This study aimed to assess wasting and associated factors among critically ill children admitted to intensive care units at the time of admission.MethodsAn institution-based prospective observational study was employed among children admitted to pediatric intensive care of the University of Gondar Comprehensive Specialized Hospital from February 1, 2018, to July 30, 2019. Data about socio-demographic, clinical, and anthropometric measurements were taken from children at the time of admission and length of hospital stay and treatment-related data were collected by chart review at discharge. Summary measures were computed and presented in the form of text, tables, and graphs. Ap-value of less than 0.2 was used to select candidate variables for multivariable analysis. A binary logistic regression model was fitted to identify factors associated with wasting. Adjusted odds ratio with 95% confidence interval (CI) was calculated and variables with a p-value less than 0.05 in the multi-variable analysis were considered to declare factors associated with wasting.ResultsThe median age at admission was 48 (IQR: 12 to 122) months. Of the total admitted children to ICU, 47.97% were undernourished, of which 32% (95%CI: (26.8% to 37.4%) were severely wasted. Caregivers who had no formal education (AOR=4.43, 95%CI 1.62 12.10), transferred from wards (AOR=2.98, 95%CI: 1.02 8.69), duration of illness ≥6 days before health facility visit (AOR=2.14, 95%CI: 1.22 3.72) and comorbidity (AOR=6.85, 95%CI: 2.93 16.05) were statistically significant factors associated with wasting.ConclusionWasting was high among children admitted to the intensive care unit. No formal education, transferred from wards and operation rooms, longer duration of illness before health facility visits, and comorbidity were factors associated with wasting. Wasted patients had higher mortality as compared to patients with no wasting. A multicenter study with larger sample size is recommended for a more generalizable result.
How one block of trials influences the next: persistent effects of disease prevalence and feedback on decisions about images of skin lesions in a large online study
Authors: Wolfe Jeremy M. 
Published: February 2022

AbstractUsing an online, medical image labeling app, 803 individuals rated images of skin lesions as either "melanoma" (skin cancer) or "nevus" (a skin mole). Each block consisted of 80 images. Blocks could have high (50%) or low (20%) target prevalence and could provide full, accurate feedback or no feedback. As in prior work, with feedback, decision criteria were more conservative at low prevalence than at high prevalence and resulted in more miss errors. Without feedback, this low prevalence effect was reversed (albeit, not significantly). Participants could participate in up to four different conditions a day on each of 6 days. Our main interest was in the effect of Block N on Block N + 1. Low prevalence with feedback made participants more conservative on a subsequent block. High prevalence with feedback made participants more liberal on a subsequent block. Conditions with no feedback had no significant impact on the subsequent block. The delay between Blocks 1 and 2 had no significant effect. The effect on the second half of Block 2 was just as large as on the first half. Medical expertise (over the range available in the study) had no impact on these effects, though medical students were better at the task than other groups. Overall, these seem to be robust effects where feedback may be 'teaching' participants how to respond in the future. This might have application in, for example, training or re-training situations.
Serological investigation of low pathogenic avian influenza and Newcastle disease virus antibodies in Japanese quails, 30 village weavers and one laughing dove in two states of Nigeria
Authors: Adebiyi Adebowale I. , Gamra Olushola , Jubril Afusat , Oluwayelu Daniel O. 
Published: February 2022

AbstractBackgroundIn spite of efforts to control avian influenza (AI) and Newcastle disease (ND) over decades, circulation of the viral causative agents among domestic and feral birds is considered implicated factors for the intermittent outbreaks of AI and ND among domesticated birds as well as commercial poultry flocks in Nigeria. In this study, sera from domestic (Japanese quails) and peri-domestic birds including laughing dove and village weavers were screened for antibodies to low pathogenic AI virus (LPAIV) and ND virus (NDV).MethodsA competitive ELISA was used to detect anti-AI virus antibodies in the sera of 101 unvaccinated Japanese quails, 30 village weavers and one laughing dove caught for human consumption in Oyo and Osun states, Nigeria. Hemagglutination-inhibiting (HI) antibodies against LPAIV were then detected in the ELISA-positive sera using H3N8, H5N2 and H9N7 subtype-specific antigens. Also, antibodies to NDV were detected and quantified in the sera using HI test.ResultsSeroprevalence of NDV antibodies from tested quail sera was 12.9% (13/101), while AI was 18.8% (19/101) with detection of anti-LPAIV H3N8, H5N2 and H9N7 antibodies. The laughing dove serum was positive for NDV and anti-LPAIV H9N7 antibodies while all sera from village weavers had no detectable LPAIV antibodies, but 26.7% (8/30) were positive for NDV antibodies.ConclusionsThis study provides serologic evidence of infection with LPAIV H3N8, H5N2 and H9N7 as well as Newcastle disease in domestic and peri-domestic birds in southwest Nigeria and highlights the potential role of these birds in the epidemiology of AI and ND.
Rapidly progressive osteoarthritis of hip: establishing and validating diagnostic criteria in the Southeast Asian population
Authors: Man Lok-chun , Yeung Yip-kan , Ho Sheung-tung , Chiu Ming-yu , Pan Nin-yuan 
Published: February 2022

Abstract
Background
The study aimed to establish quantitative diagnostic criteria for rapidly progressive osteoarthritis (RPOA) of the hip and to compare the criteria with those for other pathological hip entities in the Asian population.

Methods
From July 2011 to September 2019, 126 patients who had undergone hip replacement were retrospectively recruited from a fast-track joint replacement list. Patient demographics and radiological parameters were evaluated. Diagnosis of hip RPOA was established based on Lequesne et al’s criteria. The patients with RPOA, hip dysplasia, avascular necrosis, and primary osteoarthritis were allocated to the corresponding groups separately and compared. The diagnostic criteria of RPOA were established and validated in the sample population.

Results
Diagnosis of hip RPOA was confirmed in 18 patients. Their mean age at surgery (72 years) was significantly higher in this group than in the dysplasia and avascular necrosis groups. The mean pelvic tilt parameter (0.485) of RPOA group was significantly lower than those of other groups. The mean initial Tonnis angle (8.35°) of RPOA group was significantly higher than those of avascular necrosis and osteoarthritis groups. The differences were statistically significant between RPOA and non-RPOA groups in limb shortening rate, superior joint space narrowing, acetabular destruction, and head destruction (P < 0.05). Tonnis angle and lateral subluxation also increased significantly during the disease progression.

Conclusion
Posterior pelvic tilt and increased Tonnis angle may contribute to the pathogenesis of RPOA, leading to progressive acquired acetabular obliquity and lateral subluxation. We propose the modern comprehensive diagnostic criteria be based on the existing literature and the current findings. Further external validation is recommended.