bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reno-Protective Effect of Low Protein Diet Supplemented With α-Ketoacid Through Gut Microbiota and Fecal Metabolism in 5/6 Nephrectomized Mice
Authors: Zhu Yifan , He Haidong , Tang Yuyan , Peng Yinshun , Hu Ping , Sun Weiqian , Liu Ping , Jin Meiping , Xu Xudong 
Published: June 2022

BackgroundLow protein supplemented with α-ketoacid diet (LKD) was recommended to be an essential intervention to delay the progression of chronic kidney disease (CKD) in patients who were not yet on dialysis. Aberrant gut microbiota and metabolism have been reported to be highly associated with CKD. However, the effect of LKD on gut microbiota and related fecal metabolism in CKD remains unclear.MethodsMice were fed with normal protein diet (NPD group), low protein diet (LPD group), and low protein diet supplemented with α-ketoacid (LKD group) after 5/6 nephrectomy. At the end of the study, blood, kidney tissues, and feces were collected for biochemical analyses, histological, 16S rRNA sequence of gut microbiome, and untargeted fecal metabolomic analyses.ResultsBoth LKD and LPD alleviate renal failure and fibrosis, and inflammatory statement in 5/6 nephrectomized mice, especially the LKD. In terms of gut microbiome, LKD significantly improved the dysbiosis induced by 5/6Nx, representing increased α-diversity and decreased F/B ratio. Compared with NPD, LKD significantly increased the abundance of g_Parasutterella, s_Parabacteroides_sp_CT06, f_Erysipelotrichaceae, g_Akkermansia, g_Gordonibacter, g_Faecalitalea, and s_Mucispirillum_sp_69, and decreased s_Lachnospiraceae_bacterium_28-4 and g_Lachnoclostridium. Moreover, 5/6Nx and LKD significantly altered fecal metabolome. Then, multi-omics analysis revealed that specific metabolites involved in glycerophospholipid, purine, vitamin B6, sphingolipid, phenylalanine, tyrosine and tryptophan biosynthesis, and microbes associated with LKD were correlated with the amelioration of CKD.ConclusionLKD had a better effect than LPD on delaying renal failure in 5/6 nephrectomy-induced CKD, which may be due to the regulation of affecting the gut microbiome and fecal metabolic profiles.
Dietary Zinc Intake Affects the Association Between Dietary Vitamin A and Depression: A Cross-Sectional Study
Authors: Hu Biao , Lin Zheng-yang , Zou Run-pu , Gan Yin-wen , Ji Jia-ming , Guo Jing-xi , Li Wan-gen , Guo Yong-jing , Xu Hao-qin , Sun Dong-lin , Yi Min 
Published: June 2022

IntroductionDietary vitamin A concentrations correlate with depression. Zinc has been reported to be associated with lower depression. In addition, zinc is an important cofactor in the activation of vitamin A. However, there are few studies investigating relationships between of dietary zinc intake, dietary vitamin A intake and depression.Materials and MethodsThe data for this study came from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018 and involved 70,190 participants. We stratified participants by recommended dietary zinc intake (recommended dietary zinc intake for women: 8 mg/day, recommended dietary zinc intake for men: 11 mg/day). We further assessed the association between vitamin A and depression in participants with low and high zinc intake (interaction test) using univariate logistic regression of intake participants.ResultIn the female population we grouped the population into low and high zinc intake groups using the recommended dietary zinc intake of 8 (mg/day), with an increase in total vitamin A, the risk of depression was significantly lower in the low zinc intake group (OR: 0.85 95 CI: 0.76–0.96), while the risk of depression was increased in the high zinc intake group (OR: 1.05 95 CI: 0.95 to 1.17). Thus, in the female population, there was a significant interaction between insufficient vitamin an intake and depression (interaction likelihood ratio test of p = 0.011). In the male population we grouped the population by the recommended dietary zinc intake of 11(mg/day). Again, the population was divided into two groups with low and high zinc intake, however we did not find significant results for the interaction (p = 0.743 for the interaction likelihood ratio test).ConclusionOur findings suggest that zinc intake may influence the relationship between dietary vitamin A and depression. Of course, our findings require further randomized controlled trials to enhance the credibility.
A Mathematical Model to Assess the Effect of Residual Positive Lymph Nodes on the Survival of Patients With Papillary Thyroid Microcarcinoma
Authors: Liu Wen , Yan Xuejing , Dong Zhizhong , Su Yanjun , Ma Yunhai , Zhang Jianming , Diao Chang , Qian Jun , Ran Tao , Cheng Ruochuan 
Published: June 2022

BackgroundActive surveillance (AS) has been considered the first-line management for patients with clinical low-risk papillary thyroid microcarcinoma (PTMC) who often have lymph node micrometastasis (m-LNM) when diagnosed. The “low-risk” and “high prevalence of m-LNM” paradox is a potential barrier to the acceptance of AS for thyroid cancer by both surgeons and patients.MethodsPatients diagnosed with PTMC who underwent thyroidectomy with at least one lymph node (LN) examined were identified from a tertiary center database (n = 5,399). A β-binomial distribution was used to estimate the probability of missing nodal disease as a function of the number of LNs examined. Overall survival (OS) probabilities of groups with adequate and inadequate numbers of LNs examined were estimated using the Kaplan–Meier method in the Surveillance, Epidemiology, and End Results (SEER) database (n = 15,340). A multivariable model with restricted cubic splines was also used to verify the association of OS with the number of LNs examined.ResultsThe risk of residual m-LNM (missed nodal disease) ranged from 31.3% to 10.0% if the number of LNs examined ranged from 1 and 7 in patients with PTMC. With 7 LNs examined serving as the cutoff value, the intergroup comparison showed that residual positive LNs did not affect OS across all patients and patients aged ≥55 years (P = 0.72 and P = 0.112, respectively). After adjusting for patient and clinical characteristics, the multivariate model also showed a slight effect of the number of LNs examined on OS (P = 0.69).ConclusionsEven with the high prevalence, OS is not significantly compromised by persistent m-LNM in the body of patients with low-risk PTMC. These findings suggest that the concerns of LNM should not be viewed as an obstacle to developing AS for thyroid cancer. For patients with PTMC who undergo surgery, prophylactic central LN dissection does not provide a survival benefit.
En Bloc Resection of Right Renal Cell Carcinoma and Inferior Vena Cava Tumor Thrombus Without Caval Reconstruction: Is It Safe to Divide the Left Renal Vein?
Authors: Horodyski Laura , Gonzalez Javier , Tabbara Marina M. , Gaynor Jeffrey J. , Rodriguez-Cabero Maria , Herranz-Amo Felipe , Hernández Carlos , Shah Rushi , Ciancio Gaetano 
Published: June 2022

IntroductionIt has been suggested that inferior vena cava (IVC) reconstruction following resection of retroperitoneal tumors with IVC tumor thrombus (TT) is not required when adequate collateral circulation is present. There are no reports evaluating mid-term effects on renal function in these patients. The purpose of this study was to assess renal function after en bloc resection of right renal cell carcinoma (RCC) with obstructing IVC TT and the possible risks that may arise after left renal vein division.Materials and MethodsA bi-institutional retrospective review was performed over a 15-year period, assessing patients with right RCC and obstructing level II–IV TT. All patients underwent extensive evaluation and cardiology clearance, and informed consent was obtained for right radical nephrectomy and thrombectomy with or without IVC reconstruction with possible cardiopulmonary bypass (CPB). Patient demographics, tumor characteristics, intraoperative factors, complications, length of stay, and patient survival were evaluated. Preoperative creatinine was recorded, as was creatinine on the day of discharge and at 6 and 12 months postoperatively.ResultsTwenty-two patients were included in the study. Median age at surgery was 62.5 (range: 45–79) years, and 19 (86%) of the patients were men. One patient (5%) had a level II thrombus, 14 patients (64%) had a level III thrombus (IIIa, n = 3; IIIb, n = 6; IIIc, n = 3; IIId, n = 2), and seven patients (32%) had a level IV thrombus. Intraoperatively, median estimated blood loss was 1.35 (range: 0.2–25) L. The median length of hospital stay was 11 (range: 5–50) days. Median preoperative creatinine was 1.20 (range: 0.40–2.70) mg/dl, and postoperatively, median creatinine was 1.3 (range: 0.86–2.20) mg/dl. Median creatinine levels at 6 months and 12 months postoperatively were 1.10 (range: 0.5–1.8) mg/dl and 1.40 (range: 0.6–2.0) mg/dl, respectively. Four patients died (range: 0.1–1.3 years), and median postoperative follow-up among the 18 ongoing survivors (at last follow-up) was 1.5 (range: 0.5–7.0) years.ConclusionsResection of right RCC with an obstructing level II–IV TT without reconstruction of the IVC appears to not have a significant adverse effect on mid-term renal function after division of the left renal vein.
Clinical Application Value of Pharmacokinetic Parameters of Vancomycin in Children Treated in the Pediatric Intensive Care Unit
Authors: Zhou Bo , Xiong Wenyi , Bai Ke , Dang Hongxing , Li Jing , Xu Feng , Fu Yue-qiang , Liu Chengjun 
Published: June 2022

ObjectiveTo explore the efficacy and safety of vancomycin as measured by pharmacokinetic/pharmacodynamic parameters in children with severe infection in the Pediatric Intensive Care Unit (PICU) and to determine the appropriate threshold for avoiding nephrotoxicity.MethodsThe medical records of hospitalized children with severe infection treated with vancomycin in the PICU of a tertiary pediatric hospital from September 2018 to January 2021 were retrospectively collected. Univariate analysis was used to assess the correlation between vancomycin pharmacokinetic/pharmacodynamic parameters and therapeutic efficacy or vancomycin-related nephrotoxicity. Binary logistic regression was used to analyze the risk factors for vancomycin-related nephrotoxicity. The vancomycin area under the concentration-time curve over 24 h (AUC0–24) threshold was determined by receiver operating characteristic (ROC) curve analysis.ResultsOne hundred and 10 patients were included in this study. Seventy-six patients (69.1%) exhibited clinically effective response, while the rest exhibited clinically ineffective response. There were no significant differences in APACHE II score, steady-state trough concentration, peak concentration or AUC0–24 of vancomycin between the effective and ineffective groups. Among the 110 patients, vancomycin-related nephrotoxicity occurred in 15 patients (13.6%). Multivariate analysis showed that vancomycin treatment duration, trough concentration, and AUC0–24 were risk factors for vancomycin-related nephrotoxicity. The ROC curve indicated that AUC0–24 &lt; 537.18 mg.h/L was a suitable cutoff point for predicting vancomycin-related nephrotoxicity.ConclusionNo significant correlations were found between the trough concentration or AUC0–24 of vancomycin and therapeutic efficacy when the daily dose of vancomycin was approximately 40 mg/kg d, while the trough concentration and AUC0–24 were both closely related to vancomycin-related nephrotoxicity. The combination of AUC0–24 and trough concentration for therapeutic drug monitoring may reduce the risk of nephrotoxicity.
Pulmonary Function and Persistent Clinical Symptoms in Children and Their Parents 12 Months After Mild SARS-CoV-2 Infection
Authors: Bode Sebastian F. N. , Haendly Marisa , Fabricius Dorit , Mayer Benjamin , Zernickel Maria , Haddad Anneke Donne Maree , Frieh Pauline , Elling Roland , Renk Hanna , Stich Maximilian , Jacobsen Eva-Maria , Debatin Klaus-Michael , Janda Ales 
Published: June 2022

BackgroundPulmonary involvement is the leading cause of morbidity and mortality after severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Long-term impairment has been reported in adults with severe infection. However, most infections cause only mild symptoms or are even asymptomatic, especially in children. There is insufficient evidence regarding pulmonary outcome measures in mild SARS-CoV-2. The objectives of this study were to determine spirometry parameters after SARS-CoV-2 infection and correlate those with reported persisting symptoms in children, adolescents, and adults.MethodsData on clinical symptoms during acute infection as well as SARS-CoV-2 serology results were recorded. Twelve months after infection, spirometry was performed and information on persisting symptoms was collected using a structured questionnaire. 182 participants (108 SARS-CoV-2 positive) from 48 families were included; 53 children (&lt; 14 years), 34 adolescents and young adults (14–25 years), and 95 adults.ResultsSpirometry values did not significantly differ between the particular subgroups of the cohort (adults, adolescents, children; infected and non-infected individuals). Adults reported more symptoms during acute infection as well more persisting fatigue (29.7% of participants), reduced physical resilience (34.4%), and dyspnea (25.0%) 12 months after infection than adolescents (fatigue 26.7%, reduced physical resilience 20%, and 0% dyspnea) and children (4%, 0%, 0%, respectively). There was no correlation between persistent subjective symptoms and spirometry results.DiscussionChildren and adolescents are less affected than adults by acute SARS-CoV-2 as well as by post-infection persistent symptoms. Spirometry was not able to demonstrate any differences between healthy individuals and participants who had suffered from mild SARS-CoV-2 12 months after the infection.
A Balanced Tri-Band Substrate Integrated Waveguide Bandpass Filter With High Selectivity
Authors: Min Li , Pan Mingyue , Wang Dawei , Luo Zhenhai , Xu Congcai 
Published: June 2022

This paper proposed a balanced tri-band bandpass filter (BPF) with high selectivity based on substrate integrated waveguide (SIW) technology. The tri-band filtering response and multiple transmission zeros (TZs) are attained by elaborately merging cascaded quadruplet (CQ) topology and split topology. The proposed balanced tri-band bandpass filter is designed, which integrates high selectivity differential-mode (DM) transmission and good common-mode suppression by cleverly placing TE102-mode SIW cavity on the symmetric plane. To verify the proposed concept, a prototype of balanced tri-band BPF operating at 9.33, 9.67, and 10.02 GHz has been implemented. Measured results show eight TZs at out of DM passbands and more than 35 dB CM suppression within the DM passbands, which agree well with the simulated results.
Multifarious Linkages Between Personality Traits and Psychological Distress During and After COVID-19 Campus Lockdown: A Psychological Network Analysis
Authors: Liu Tzu-Hsuan , Xia Yiwei , Ma Zhihao 
Published: June 2022

BackgroundThe novel coronavirus disease pandemic is still proliferating and is not expected to end any time soon. Several lockdowns and social distancing measures might be implemented in the future. A growing body of research has explored the effect of personality on individuals' psychological wellbeing during the pandemic. However, most prior studies have not discussed the dynamic and reciprocal transactions between personality and psychological distress in various situations. Therefore, this study aims to explore the internal mechanisms of the ways in which certain personality traits triggered specific symptoms during and after college lockdown, by using network analysis.MethodsBased on survey data from 525 university students in China, the study detected the connection between individual personality and psychological distress through network analysis. Of the participants, 70.1% were female, and 20.9% were male. The mean age of the participants was 19.701 (SD = 1.319) years. We estimated networks via two steps: First, two networks that only contain the Big Five personality traits and the six symptoms of psychological distress during and after the lockdown measure were estimated. Second, we add control variables and re-estimated the networks to check whether the linkages among the Big Five personality traits and the six symptoms of psychological distress observed in the first step were stable. Moreover, we employed strength centrality as the key indicator to present the potential significance of diverse variables within a network.ResultsThe findings demonstrate that, first, “depress” was the central symptom in the network during the college lockdown, while “efforts” was the central symptom after the lockdown. Second, the symptoms of “restless” and “worthless” significantly declined after the lockdown. Third, we found that there is an internal mechanism through which personality affected certain psychological symptoms during and after lockdowns. Specifically, neuroticism triggered certain symptoms during and after the lockdown, while extraversion and conscientiousness suppressed certain symptoms. Substantial evidence on internal linkages is imperative to develop effective interventions.ConclusionThis study explores the internal mechanisms of the ways in which certain personality traits trigger specific symptoms. Overall, our results provide empirical evidence that personality traits play a key role in how individuals with certain traits respond to college lockdown during a pandemic. The study makes a significant contribution to the literature because it is among the first few studies which explores the effects of personality traits on individual psychological distress using network analysis during the pandemic.
A New Traceless Technique for Cosmetic Closure of Minimally Invasive Incision and Chest Tube Fixation After Uniportal Video-Assisted Thoracoscopic Surgery
Authors: Chen Zihao , Xin Ning , Huang Kenan , Wei Rongqiang , Liu Chengdong , Niu Shiwen , Xu Zhifei , Ding Xinyu , Tang Hua 
Published: June 2022

BackgroundWith uniportal video-assisted thoracoscopic surgery (VATS) becoming mainstream, how to make the incision cosmetic has attracted much attention. This study aimed to introduce a new traceless method for cosmetic closure of the incision and a special procedure for chest tube fixation after uniportal VATS and to evaluate the feasibility, effectiveness, and safety of this new technique.MethodsIn this retrospective study, a total of 258 consecutive patients who underwent uniportal VATS were included. Among them, 127 patients were treated with a conventional method, and 131 patients were treated with a new method.ResultsPatients in the new method group had a significantly less incidence of subcutaneous emphysema after the chest tube was removed. The incidence of pneumothorax after the chest tube was removed and fat liquefaction of chest incision was not significantly different between the two groups. No differences in the incidence of pneumothorax after chest tube removal and fat liquefaction of postsurgical incision were found between the two groups. Additionally, there was also no significant difference in follow-up items.ConclusionsTaken together, our results showed that this new method for minimally invasive incision closure and chest tube fixation after uniportal VATS was as feasible, effective, and safe as the conventional one but more cosmetic.
Aplikasi Kamus Simplisia Dan Resep Obat Tradisional (Sidota) Berbasis Android
Authors: Lutfiah Lailatul 
Published: June 2022

Simplicia is a natural ingredient used in the manufacture of traditional medicine, in this pandemic era, many families prefer to consume herbal medicine instead of going to the doctor because they are worried about contaminated by Covid. By utilizing an Android Smartphone that almost all people have, SIDOTA's goal is to provide information on the correct processing of simplicia and can get maximum medicinal effects. In addition, SIDOTA can facilitate the learning process of Pharmacy students or students majoring in Pharmacognosy subjects or subjects. In this paper, the writer used the Waterfall method for the development method, with the Analysis, Design, an Implementation of the design. This application displays simplicia information data as well as recipes and ways of making traditional medicines.
Din Unsurunun Dış Politika Etkileri: Trump Dönemi ABD-İsrail İlişkilerinde Evanjelizmin Rolü Örneği
Authors: COBANOGLU Ali 
Published: June 2022

Öz: Westphalia Barış Antlaşması ile birlikte Batı’da yaşanan sekülerleşme sürecinin küresel çapta etki göstermesiyle “din etkisi” uluslararası sahada önemini yitirmiştir. Uluslararası ilişkilerdeki köklü değişikliklerin sebebi olarak görülen, “küreselleşme” ile birlikte uluslararası politikanın Westfalen ayrılığı son bulmaya başlamıştır. Din etkisi yeniden yükselişe geçmiştir. Din, uluslararası ilişkilerde beklentilerin dışına çıkarak demokratik ortam, teknoloji ve küreselleşmenin de etkisi ile siyasi nüfuzunu artırmaktadır. Din, devletlerin, toplumun ve bireylerin kendi kimliklerini tanımalarında en önemli unsurlardan biridir. Dini inançlar, inanç merkezli yapılar ve çıkar grupları dış politika karar alma süreçlerinde dikkate değer katkıları olduğu gibi yalnızca stratejik boyutta değil dış politikanın icrası safhasında da yer almaktadırlar. Bunun günümüzde en çarpıcı örnekleri, Amerikan Evanjelist dini gruplarının etki ve ilgi alanında olan “ABD-İsrail Dış Politika” ilişkisinde yaşanmaktadır. Evanjelizm, Amerika Birleşik Devletleri’nin kuruluş yılları itibariyle, Amerikan ulusal kimliğinin inşası aşamalarında çok köklü bir yer edinmiştir. Evanjelistler ABD’de her geçen gün artan siyasi güçleri ile ülkenin uluslararası politikalarına yön verebilecek bir unsuru haline gelmişlerdir. Evanjelistlerin ortak norm, kimlik ve kültür bağları kurdukları Yahudilerle olan ilişkileri de çok kuvvetlidir. Özellikle, kendini bir Protestan ve bir Presbiteryen olarak tanımlayan Başkan Donald Trump döneminde, ABD’nin Kudüs’ü İsrail’in başkenti olarak tanıması ve İsrail’i Golan Tepeleri’nde egemen ülke olarak nitelendirmesi gibi somut gelişmeler Evanjelik dış politik gücün birer göstergesi haline gelmiştir. Bu makale “Sosyal İnşacı” perspektiften ABD-İsrail ilişkilerinde din unsurunun etkisini araştırmayı amaçlamaktadır.
Anahtar Kelimeler: Din, Sosyal İnşacılık, Evanjelizm, Dış Politika, Kimlik, Küreselleşme.
President’s Message for the 2nd Edition of the ISAK Journal
Authors: Marfell-Jones Mike 
Published: June 2022

It is with pleasure that ISAK announces the second edition of the International Journal of Kinanthropometry which will showcase research in the area of Anthropometry and its applications. As with the first issue, significant COVID pressures continue to hamper the production sequence. Thus, contributions have once again been by invitation and evaluated for acceptability by the editorial team. Henceforward, a formal review process will be strictly adhered to and the Journal will only publish refereed scientific papers plus research reviews and case studies.
Once again, we have an interesting selection of papers for you to read and I thank all contributors for both their research and their willingness to share it with us.
Our sincere gratitude for this production goes to the Journal’s Editor-in-Chief, Dr Anup Adhikari and the publication team led by Dr Babu Balraj from IOR Press all of whom have had to deal with significant challenges posed by the pandemic.