bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infusion-Related Side-effects during Convection Enhanced Delivery for Brainstem-Diffuse Midline Glioma/Diffuse Intrinsic Pontine Glioma
Authors: Hollingworth Milo Alexander , Zacharoulis Stergios 
Published: May 2022

Abstract
Introduction: Side-effects during convection enhanced delivery (CED) are poorly understood. We intended to determine the frequency of side-effects during brain stem infusion and determine risk factors for side-effects persisting longer than 24 hours. Methods: Children with a radiological diagnosis of brain stem diffuse midline glioma/Diffuse Intrinsic Pontine Glioma were treated on compassionate grounds with awake infusion of carboplatin and sodium valproate into the brain stem using the 4-catheter (2 trans-cerebellar 2 trans-frontal) chronic, intermittent Renishaw Drug Delivery System. We used change in the Pontine Neurological Observation Score (PONScore), a standardised neurological assessment tool, to identify side-effects during infusion. Recovery was determined by retrospective chart review. Results: 55 infusions were performed in 8 children (3-11 years). Mean PONScore increased during infusion from 3.3 to 5.7 (p-value >0.001). One hundred and fifty-seven infusion-related side-effects were identified including headache (33/157) and limb weakness (49/157). Fifty-four side-effects persisted >24 hours. Side-effects that had occurred during a previous infusion and those that occurred during infusion via trans-cerebellar catheters were more likely to be persistent with OR 2.333 (95% CI 1.094-4.976; p-value =0.028) and 2.155 (1.029- 4.513; p-value=0.042) respectively. If infusion was stopped or titrated at onset rather than continued, the side-effect was less likely to persist >24 hours, OR 0.473 (95% CI 0.177-0.948; p-value=0.037). Most side-effects developed within the first three millilitre of infusion. Conclusions: Side-effects during brainstem infusion are common, can be transient or persist longer than 24 hours. Neurological injury during infusion may be time dependent and accumulative rather than volume dependent.
Yield performance of potato (Solanum tuberosum L) under integrated use of blended NPS fertilizer and vermicompost in Horroguduru area, Western Ethiopia
Authors: Wagari Alemayehu , Jalata Zerihun , Gobena Amsalu 
Published: May 2022

Abstract
Potato is a high-yielding potential crop grown for its high nutritional value but constrained with low soil fertility. This study was conducted at Gitilo site, western Ethiopia during 2019 year with the aim to analyze the impact of vermicompost and blended NPS fertilizer rates on potato yield associated traits. The treatments consisted of four rates of NPS fertilizers (0, 150, 200, and 250 kg NPS ha− 1) and four rates of vermicompost (0, 4, 6, and 8 tha− 1) in 4x4 factorial which becomes laid out in randomized complete block design with 3 replications. The result revealed significant influence of NPS fertilizers and vermicompost on all parameters measured indicating a high response of potato to the treatments. The application of blended NPS fertilizer integrated with vermicompost resulted superior to the application of either NPS fertilizer or vermicompost alone. The combined application of 8tha− 1 vermicompost with 250 kg ha− 1 blended NPS fertilizer resulted in maximum value for most of the yield parameters including marketable tuber yield (27.4 tha− 1) and total tuber yield (27.9 tha− 1).. The result suggests the application of 250 kg ha− 1 blended NPS with 8 t ha− 1 vermicompost is profitable with a net benefits of about 2761USD with a 315.9% marginal rate of return. Since at increasing levels of treatment resulted an increasing yield trend, further study is required to identify the optimum rate of recommendation of both fertilizers.
The real-world therapeutic analysis of first-line immunotherapy in Chinese patients with Drive Gene Positive for Advanced Non-Small Cell lung cancer
Authors: Liu Lei , Zhao Jing , Zhuo Xiaoli , Lai Jingjiang , Wang Jingliang , Jiang Fengxian , Xu Wei , Luan Fang , Yang Shuping , Lin Xiaoyan , Fu Guobin 
Published: May 2022

Abstract
Background: Immune checkpoint inhibitors are widely used in advanced non-small cell lung cancer, but in some studies it has been shown that patients with genetic mutations didn't benefit from immunotherapy. Our aim was to explore the efficacy of programmed death-1 (PD-1) and programmed death-receptor-ligand 1 (PD-L1) inhibitors in the first-line treatment of advanced NSCLC with driver gene mutations in real-world settings and to analyze potential prognostic correlates. Methods: Retrospective analysis of patients with advanced NSCLC treated with PD-1/PD-L1 inhibitors at Shandong Provincial Hospital from May 2019 to October 2021, identification of patient driver gene mutation status using ARMS-PCR and NGS. The basic clinical characteristics, objective response rate (ORR), progression free survival (PFS) and other clinical data of patients were also collected to evaluate the clinical efficacy and potential prognostic factors of treatment for patients with driver gene mutations. Results: A total of 86 NSCLC patients were enrolled in the study. The main pathological type of patients was adenocarcinoma (57.0%), the overall mutation rate was 43.0% (n=37), including KRAS (n=20), TP53 (n=18), EGFR (n=3), BRAF (n=3),Her-2 (n=3), MET (n=3),ROS1 (n=1), NRAS (n=1), with an overall ORR of 16.10% and a disease control rate (DCR) of 82.23%.At the time of follow-up cutoff , the median PFS of the whole group of patients was 13.2 (95%CI:10.6-15.8) months.Patients with negative driver mutations treated with ICIs had a longer median progression-free survival compared to patients with mutations (13.5 vs 11.6 months, P=0.50). The survival benefit varied among the different mutation subgroups. Overall, NSCLC patients with driver gene mutation had slightly lower PFS than patients with negative mutation with first-line immunotherapy, but there was no statistical difference. PD-L1 expression level was positively correlated with PFS of immunotherapy. Conclusions: In this real-world setting, the efficacy of first-line immunotherapy in NSCLC patients with driver gene mutations is similar to that in mutation negative patients, immune monotherapy may be more effective in patients with positive driver mutations, and immune efficacy is positively correlated with PD-L1 expression levels.
High accuracy prediction of behaviour with slow, low-cost accelerometers in the wild boar
Authors: Ruf Thomas , Krämer Jennifer , Vetter Sebastian , Bieber Claudia 
Published: May 2022

Abstract
Background: We classified the behaviour of wild boar, kept under semi natural conditions in a large outdoor enclosure, using acceleration data. The prediction was made using a machine learning algorithm, specifically a random forest model in the open software h2o. Remarkably, highly accurate prediction was possible using ear-tag acceleration sensors that sampled data only at a frequency of 1 Hz. This measurement device was used to minimise the potentially harmful effects caused by the repeated capture of wild animals to exchange batteries.﻿Results: Overall accuracy was as high as 94.7 %, but sensitivity ranged from 1.0 for common behaviours like foraging to 0.0 % in the case of rare events (e.g., scrubbing). Results show that static features of unfiltered acceleration data, as well as of gravitation- and orientation filtered data, were used in the prediction of behaviour. The waveform of certain behaviours in the sampled frequency range played no important role. ﻿Conclusions: Low-cost, slow accelerometers can be used to correctly classify behaviour in the wild boar. The positively identified behaviours, such as food intake and lactation, could be of interest for wildlife managers attempting to control population growth in this pest species. In addition to the model predicting behaviour, we provide several universal R-scripts that ease the generation of input files for machine learning.
Incidence and predictors of postoperative persistent pain in breast cancer survivors: A retrospective study
Authors: Zhang Yu , Qin Jiazhu , Yan Yixiu , Huang Luping , Pan Wei , Du Wenwen 
Published: May 2022

Abstract
Purpose: This retrospective cohort study aimed to determine the incidence and risk factors of postoperative persistent pain in breast cancer survivors in the fifth year after breast cancer surgery. Methods: We retrospectively reviewed the data of 303 breast cancer patients who underwent elective breast cancer surgery in the Department of Anesthesiology of the First Affiliated Hospital of Wenzhou Medical University between January 2015 and June 2016. The patients were divided into two groups based on the presence or absence of pain. The patient data were obtained from the patient records system. Univariate and multivariate logistic regression analyses were used to explore the risk factors of persistent postoperative pain in breast cancer survivors. Results: The incidence of postoperative persistent pain in the fifth year after breast cancer surgery was 31.68%, and half of the patients with postoperative persistent pain reported chest wall pain. Stepwise logistic regression analysis showed that preoperative chronic pain [OR=3.42; 95%CI (1.28-9.15), P=0.014], postoperative radiotherapy and chemotherapy [OR=2.18; 95%CI (1.14-4.15), P=0.017], medical insurance [OR=3.17; 95%CI (1.17-11.74), P=0.026], pain a month after surgery [OR=11.60; 95%CI (6.29-21.39), P<0.001], and axillary dissection [OR=0.53; 95%CI (0.29-0.97), P=0.039] were significantly associated with postoperative persistent pain in the fifth year after breast cancer surgery. The area under the curve was 0.83. Conclusion: Patients with breast cancer who have preoperative chronic pain, do not need axillary dissection during surgery, receive postoperative radiotherapy and chemotherapy, enjoy medical insurance, and still have pain one month after surgery are more prone to postoperative chronic pain. Therefore, awareness should be created, intraoperative analgesic drugs should be administered, and pain should be actively controlled within one month after surgery to reduce the prevalence of postoperative persistent pain in breast cancer survivors.Trial registration number for randomized clinical trials：The study protocol was registered at Chinese Clinical Trial Registry (http://www.chictr.org.cn) with identifier ChiCTR2100054013.
Effect of commercial diets on growth performance and stress in tomato clownfish (Amphipriom frenatus): A first approach
Authors: Boglino Anaïs , Caicedo Juan Pablo Rivera , Madrid Jorge , Ibarra-Zatarain Zohar 
Published: May 2022

Abstract
The genus Amphiprion, which species are typically known as clownfish or anemone fish, are among the most commercialized marine ornamental fish species in the world. The present study evaluated three commercial aquaculture diets (A = 40% protein and 9% of crude fat, B = 45% protein and 14% of crude fat, C = 38% protein and 6% of crude fat) on the growth performance and stress response of juveniles of the tomato clownfish A. frenatus during six weeks. Initial and final weight, length, weight gain, relative weight gain, condition factor, specific growth rate and survival were evaluated to determine growth performance. To analyze the stress response, individuals were subjected to a novel environment and a mirror test both performed on the second and fifth week of the experiment. Results demonstrated that diet B significantly increased (P < 0.05) weight and length, weight gain, relative weight gain, specific growth rate and had a better feed conversion rate. In terms of the stress response, fish from treatment B exhibited higher activity and higher swimming velocity (P < 0.05). Additionally, fish from same diet remained closer to the mirror and performed more attacks attempts than fish from treatments A and C. Furthermore, tomato clownfish showed consistent behavioural responses over time. These results demonstrate that diets not only influences growth performance, but also impacts the stress response of juvenile tomato clownfish. This might be of interest to the aquaculture industry of this fish species to select adequate diets and to develop protocols to improve welfare of fish kept in captivity.
Pharmacists implementing collaborative pharmaceutical care plans in patients with chronic disease: a prospective cohort feasibility study
Authors: Percival Matthew , Freeman Christopher , Cottrell Neil 
Published: May 2022

Abstract
Background: Pharmacists working in general practices provide medication reviews with suggestions to general practitioners to implement their recommendations to optimise medications. The next step is a model where the pharmacist takes on responsibility for implementing their recommendations. Aim: To explore the feasibility of an expanded model of collaborative pharmaceutical care in which the pharmacist has increased responsibility to manage patients with chronic diseaseMethod: This was a prospective cohort study (March to September 2018). A pharmacist developed a collaborative pharmaceutical care plan to identify drug related problems in patients with chronic disease in three general practices. The pharmacist consulted with the general practitioner discussing recommendations to manage drug related problems identified and recommendations the general practitioner was happy for the pharmacist to implement. The pharmacist implemented agreed recommendations and followed patients for six months. Outcome measures included number of recommendations implemented and drug related problems identified.Results: The pharmacist made 135 recommendations to optimise medicine use of which 126 (93.3%) were accepted by the general practitioner with 105 (83.3%) implemented by the 6-month follow up. The pharmacist was responsible for implementing 62 (49.3%) of the 126 accepted recommendations. The median number of drug related problems per patient reduced at six months compared to baseline (5 [IQR 3.3 – 7.0] vs. 2 [IQR 1.0 – 3.0]). Conclusion: The results confirm the feasibility of a pharmacist-general practitioner collaborative model within a general practice setting in Australia. The general practitioner accepted a high proportion of the pharmacist’s recommendations and almost half were implemented by the pharmacist.
Factors associated with emergency department length of stay and in-hospital mortality in critically ill patients admitted to the intensive care unit from the emergency department: a nationwide analysis
Authors: Lee Kyung-Shin , Min Hye Sook , Moon Jae Young , Lim Daesung , Kim Younghwan , Ko Eunsil , Kim You Sun , Kim Joohae , Lee Jeehye , Sung Ho Kyung 
Published: May 2022

Abstract
Background: Prolonged emergency department length of stay (EDLOS) in critically ill patients leads to adverse outcomes, including an increased mortality risk. This nationwide study investigated patient and hospital characteristics associated with prolonged EDLOS and in-hospital mortality in adult patients admitted from the emergency department (ED) to the intensive care unit (ICU).Methods: We conducted a retrospective cohort study using data from the National Emergency Department Information System. Prolonged EDLOS was defined as an EDLOS of 6 h or more. We constructed multivariate logistic regressions to model the effects of patient and hospital variables as predictors of prolonged EDLOS and in-hospital mortality risk.Results: Between 2016 and 2019, 657,622 adult patients were admitted to the ICU from the ED, representing 2.4% of all ED presentations. The median EDLOS of the overall study population was 3.3 h (interquartile range, 1.9–6.1 h). In total, 25.3% of patients had prolonged EDLOS. Patient characteristics associated with prolonged EDLOS included night-time ED presentation, assignment of initial triage to less urgency, and one or more comorbidities. Hospital characteristics associated with prolonged EDLOS included a higher number of staffed beds and a higher ED level. Prolonged EDLOS was associated with in-hospital mortality after adjustment for selected confounders (adjusted odds ratio,1.18; 95% confidence interval CI, 1.16–1.20). Patient characteristics associated with in-hospital mortality included age ≥ 65 years, transferred-in, mechanical ventilation in the ED, assignment of initial triage to more urgency, and one or more comorbidities. Hospital characteristics associated with in-hospital mortality included a lower number of staffed beds and a lower ED level.Conclusions: In this nationwide analysis, 25.3% of critically ill patients admitted to the ICU from the ED had a prolonged EDLOS, which in turn was significantly associated with an increased in-hospital mortality risk. Hospital characteristics were also associated with prolonged EDLOS and in-hospital mortality, including the number of staffed beds and the ED level.
Ethnobotany of Wild Edible Plants in Multi-ethnic Areas of Gansu-Ningxia-Inner Mongolia Junction Zone
Authors: Jia Xiaohuan , Zhao Yongxia , Zhu Yunyue , Zen Xin , Liang Xuehui , Xie Jian , Wu Faming 
Published: May 2022

Abstract
Introduction: In recent years, research on wild edible plant resources has become a hotspot.Hassan Nature Reserve is a multi-ethnic mixed area mainly composed of Han, Hui and Mongolian. The edible development of wild plant resources in this area is extremely high. However, with the advancement of urbanization and the development of modern agricultural technology, such resources have been seriously damaged, and the related traditional knowledge such as national medicine has been lost.Methods: With the methods of literature study, interview with village and community organizations, participatory observation and quantitative evaluation of ethnobotany, the wild edible plants in hassan region of gansu-ningxia-inner mongolia interchange belt were investigated and studied.Results: The survey results showed that there were 53 species (varieties) of wild edible plants belonging to 24 families in this area, with 8 species and 7 species in Compositae and Liliaceae, respectively, being the most abundant. The young stems and leaves were the most edible parts, with 17 species, followed by the fruits (including young fruits) with 16 species. In addition, the edible parts also included root or rhizome (bulb), seed, whole plant, skin, etc. There were two types of raw food and cooked food, raw food was mainly used as snacks, mainly fruit; The cooked food is mainly vegetables with tender stems and leaves as the main, in addition can also be used as seasoning, medicinal diet, emergency food in the famine years. Important (CFSI>500) wild edible health-care plants in the region include: Mulgedium tataricum (L.) DC., Nostoccommune, Sonchus arvensis L., Taraxacum mongolicum Hand.-Mazz., Allium schoenoprasum, Robinia pseudoacacia, Hemerocallis citrina Baroni, Elaeagnus angustifolia Linn., Medicago sativa L., Ulmus pumila L., Stachys sieboldii Miq. var. sieboldii, Tooinensis (A. Juss.) Roem. var. sinensis, had high utilization value and utilization rate in the locality.Conclusion: In summary, the species, edible parts, edible categories, edible methods and health care functions of wild edible plants in this area are diverse, and the traditional utilization knowledge is rich, and some wild plants have high development value.
Associations between IBS, IBD and the risk of Insomnia: An Observational Analysis and Genome-wide Interaction Study
Authors: Cai Qingqing , Zhang Huijie , Qin Xiaoyue , He Dan , Zhao Yijing , Wei Wenming , Chu Xiaoge , Shi Sirong , Zhang Na , Li Chune , Chen Yujing , Pan Chuyu , Zhang Jingxi , Zhang Zhen , Zhang Feng 
Published: May 2022

Abstract
Background: Irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD) were reported to be associated with mental disorders. But limited efforts were made to investigate the relationship between IBS/IBD and the risk of insomnia, especially from genetic perspective. Methods: Based on the UK Biobank cohort, we first calculated the polygenic risk scores (PRS) of IBS and IBD. Linear regression analyses were conducted to evaluate the association of IBS/IBD PRS with 7 sleep-related traits (N = 285,538-376,545), such as insomnia, short sleep. Genome-wide interaction study (GWIS) was performed to test the interacting effects of SNP × IBS PRS/Crohn's disease (CD) PRS on the risk of insomnia. Linkage disequilibrium score regression (LDSC) was performed to evaluate the genetic correlation between IBS/IBD and sleep-related traits by using genome-wide association study (GWAS) summary data of IBS (N = 29,524), IBD (CD: N = 5,956; UC: N = 6,968) and sleep-related traits (N = 1,331,010). Results: For IBS, observational analyses showed that IBS PRS was significantly associated with insomnia (P = 2.37×10-2), short sleep (P = 2.49×10-2) and healthy sleep score (P = 9.95×10-4). LDSC identified significant genetic correlation of IBS and sleep-related traits, such as insomnia (P = 1.12×10-23). GWIS observed significant interaction effects of LTBP1 ´ IBS PRS for insomnia (rs184718843, P = 6.04×10-9). For IBD, we found an association between CD PRS and insomnia (P = 3.57×10-2). LDSC detected significant genetic correlation between CD and dozing (P = 1.20×10-3). For CD PRS, GWIS detected several suggestive interaction signals for insomnia, such as ANKRD30A (rs551207458, P = 7.10×10-7). Conclusion: Our results suggested that IBS and IBD were functionally related to insomnia, and reported several candidate genes interacting with IBS/IBD PRS for insomnia.
An Uncommon Presentation of Obstructive Colonic Cancer: An Extensive Ischemic Colitis
Authors: Kachornvitaya Pattharasai , Sapsupan Wasu 
Published: May 2022

Abstract
Obstructive colonic cancer is a common presentation of colonic cancer but extensive ischemic colitis proximal to an obstructive colonic cancer is an uncommon condition. It has been referred to by various terms in the literature such as obstructive colitis. A 59-year-old female presented with fever, abdominal pain and diarrhea. Abdominal CT revealed a short segment of circumferential bowel wall thickening at sigmoid colon with diffuse colonic wall thickening proximal to the lesion. Emergency surgery was performed, and intraoperative findings found a tumor located at sigmoid colon causing proximal colonic obstruction. The serosal surface of proximal colon appears normal but intraluminal appear black in color. The major vessels were patent. Total colectomy with side-to-end ileo-rectal anastomosis was performed. Obstructive colitis is a rare condition, and its etiology remains unclear. We report our case to share an experience and to review the literature to facilitate the recognition and proper management.