bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards a Doctrinal Pragmaticism: Charles S. Peirce and the Nature of Doctrine
Authors: Hollingsworth Andrew 
Published: August 2022

Summary
In this paper, I aim to retrieve insights from the philosophy of the polymath Charles Sanders Peirce, which he referred to as pragmaticism. What Peirce is perhaps best known as is being the father of pragmatism. In order to differentiate his project from other thinkers such as William James and John Dewey, who likewise referred to their projects as pragmatism, he renamed his pragmatism to pragmaticism.Peirce’s pragmaticism has much to offer theologians, especially concerning theological method. I demonstrate this claim by showing the usefulness of three of Peirce’s pragmaticist concepts. The first section of this paper briefly explicates the foundational concepts of pragmaticism, which are the pragmatic(ist) maxim, the semiotic nature of understanding, and fallibilism. The second section of this paper provides a sketch of the benefits these three concepts have for theological method.
A simple, bed-side tool to assess evoked pressure pain intensity
Authors: Hostrup Søren Nicolai Frederiksen , O’Neill Søren Francis Dyhrberg , Larsen Jesper Bie , Arendt-Nielsen Lars , Petersen Kristian Kjær 
Published: August 2022

Abstract

Objectives
Existing equipment for quantitative sensory testing is generally expensive and not easily applicable in a clinical setting thus simple bed-side devices are warranted. Pressure hyperalgesia is a common finding in patients with musculoskeletal pain and an experimental model is delayed-onset muscle soreness (DOMS). DOMS is characterised by muscle hyperalgesia and some studies report facilitation of temporal summation of pain. This study aimed to detect DOMS induced muscle hyperalgesia and temporal summation of pain using a newly developed bed-side quantitative sensory testing device to deliver standardised pressure.

Methods
Twenty-two healthy participants participated in two sessions with the second session approximately 48 h after baseline. Pressure pain intensities were assessed from the gastrocnemius muscle with four probes calibrated to apply 2, 4, 6 and 8 kg, respectively. Temporal summation of pain (10 stimuli delivered at 0.5 Hz using the 6 kg probe) intensities were assessed from the same location. DOMS was evoked in the gastrocnemius muscle by an eccentric exercise. Sleepiness and physical activity were measured with the Epworth Sleepiness Scale and the Global Physical Activity Questionnaire to investigate if they were associated with the quantitative sensory testing measures.

Results
Pressure pain intensity was significantly increased 48 h after induction of DOMS when compared to baseline for all four probes (p<0.05). Temporal summation of pain was not statistically significant affected by DOMS and sleep quality and physical activity did not associate with any of the measures.

Conclusions
This study introduces a simple, bed-side assessment tool for the assessment of pressure pain intensity and hence hyperalgesia and temporal summation of pain.
Endometrial gland-specific progestagen-associated endometrial protein and cilia gene splicing changes in recurrent pregnancy loss
Authors: Pearson-Farr Jennifer E , Wheway Gabrielle , Jongen Maaike S A , Goggin Patricia , Lewis Rohan M , Cheong Ying , Cleal Jane K 
Published: August 2022

Endometrial glands are essential for fertility, consisting of ciliated and secretory cells that facilitate a suitable uterine environment for embryo implantation. This study sought to determine whether an endometrial gland-specific transcriptome and splicing profile are altered in women with recurrent pregnancy loss. Our data provide a comprehensive catalogue of cilia and progestagen-associated endometrial protein (PAEP) gene isoforms and relative exon usage in endometrial glands. We report a previously unannotated endometrial gland cilia transcript GALNT11 and its susceptibility to exon skipping. Key endometrial receptivity gene transcripts are also reported to change in endometrial glands of women with recurrent pregnancy loss. The endometrial gland cilia and PAEP targets identified in this study could be used to identify a perturbed endometrium, isolate causes of recurrent pregnancy loss and develop targeted therapies in personalised medicine.

Lay summary
Successful embryo implantation is a trade-off between the lining of the womb which receives an implanting embryo, termed the endometrium, and a good quality embryo. For days 21–24 of the menstrual cycle, the endometrium undergoes changes into a receptive state in which it can receive an implanting embryo. Inappropriate endometrial receptivity is thought to underlie recurrent pregnancy loss. Improving pregnancy success in women with recurrent pregnancy loss requires an increased understanding of the endometrium at the molecular level. Genes contain the instructions for the cell and which genes are turned on or off determine how well it can do its role. We sought to determine a gene expression pattern of human endometrial glands in women with recurrent pregnancy loss (n = 5) vs a control group (n = 5). We identify target genes altered in women with recurrent pregnancy loss. Endometrial gland markers could be used to identify inappropriate endometrial receptivity.
Changes in the lipidogram and hemostasis system in elderly patients with myocardial infarction, hypertension depending on the severity of senile asthenia syndrome
Authors: Agarkov N. M. , Makkonen K. F. , Titov A. A. , Mitikhina M. S. , Kolpina L. V. 
Published: August 2022

Background. The development of myocardial infarction (MI) is associated with the lipid and hemostatic disorders, which are not fully investigated in patients with senile asthenia syndrome (SAS).Objective. To analyze changes in the lipidogram and hemostasis system in elderly patients with MI, hypertension (HTN), depending on the severity of SAS.Design and methods. Indicators of lipid metabolism and hemostasis system were studied in patients aged 60–74 years with MI, grade 1–2 HTN (n = 80); 60–74 years with MI, grade 1–2 HTN with senile preasthenia (SP); 60–74 years with MI, grade 1–2 HTN and SAS in the period from 2 to 4 days after MI onset. The diagnosis of MI without ST segment elevation was established based on the criteria of the European Society of Cardiology, HTN was diagnosed in accordance with the “National Recommendations of the All-Russian Scientific Society of Cardiology”, SAS — according to the criteria of L.P. Fried. The study of lipid metabolism indicators performed on the analyzer “KoneLab 300” and “PersonalLab”, hemostasis systems — with the use of reagents “Technology Standard”.Results. In elderly patients with MI, HTN and SP, the level of triglycerides is significantly higher compared to those without senile asthenia (1,8 ± 0,04 vs. 1,4 ± 0,03 mmol/l), low-density lipoproteins (4,2 ± 0,07 vs. 3,6 ± 0,05 mmol/l), antithrombin III activity (105,8 ± 2,2 vs. 97,4 ± 2,3%), plasminogen activator inhibitor (291,5 ± 3,8 vs. 275,2 ± 3,6 ng/ml). With the progression of senile transformation into SAS, these changes in patients 60–74 years old with MI, HTN are aggravated, and especially changes in apoliprotein-A1, leptin, very low density lipoproteins, fibrinogen, plasminogen activator inhibitor, in globulin-dependent fibrinolysis, which indicates a negative effect of SAS on lipidogram and hemostasis indicators.Conclusions. The changes in lipidogram and hemostasis indicators should be taken into account in the management of elderly patients with MI, HTN and SAS symptoms, they should be also considered as predictors of the MI outcomes.
Origin and emplacement of the Blue Diamond landslide breccia, southern Nevada, U.S.A.
Authors: Ferry Nicholas , Sturmer Daniel , Ward Dylan , Taylor Wanda , Brett Carlton 
Published: August 2022

ABSTRACT
Landslide deposits are common in basin fill of tectonically active areas, including the Basin and Range province of western North America. However, interpreting and reconstructing ancient landsliding events from these deposits is challenging, but can be aided by detailed field analysis. Remnants of the Blue Diamond landslide breccia are exposed capping hills and ridges in the foothills of the eastern Spring Mountains near Blue Diamond, Nevada, USA. Uncertainties surrounding the origin and emplacement of the ancestral Blue Diamond landslide have emerged based on the disparate distribution of landslide outcrops. Therefore, in this study we used detailed sedimentological data and observations to interpret a two-phase emplacement history for the Blue Diamond landslide.
Sedimentological observations are consistent with Blue Diamond landslide breccia emplacement as a rock avalanche. The presence of clastic dikes and flame structures and negligible incorporation of bedrock substrate material suggest that runout occurred over a saturated substrate. Flow transformation into a debris avalanche is ruled out because clast-count data show that debris entrainment was not sufficient to act as the sole mechanism behind the excessive mobility experienced by the Blue Diamond landslide. Instead, we propose that the excessive mobility was driven by flow entrainment of large Aztec Sandstone boulders and interaction with a saturated runout path substrate that caused a reduced basal frictional resistance, enabling initial emplacement onto Blue Diamond Hill. We therefore suggest that the Blue Diamond landslide was derived from a source area about 8.5 km northwest of the Blue Diamond townsite and flowed into the Blue Diamond Hill site where it was emplaced onto Moenkopi Formation atop the hill during the Miocene. Due to loading by this new overburden, incompetent gypsum horizons failed in the upper Kaibab Formation stratigraphically below the Moenkopi Formation. These failed gypsum horizons then served as a compound landslide rupture surface, transporting the overlying Moenkopi Formation and landslide breccia. This secondary emplacement likely ceased by late Miocene to Pliocene time.
Extended Pelvic Lymph Node Dissection during Robotic Prostate Surgery Reduces Biochemical Recurrence: A Propensity Score- matched Analysis for High-risk Prostate Cancer
Authors: Yashi Masahiro , Yokoyama Megumi , Nakamura Gaku , Uematsu Toshitaka , Suzuki Issei , Sakamoto Kazumasa , Nishihara Daisaku , Kijima Toshiki , Ishida Kazuyuki , Kaji Yasushi , Kamai Takao 
Published: August 2022

Abstract
Objectives: To avoid misunderstandings based on the failure to demonstrate oncological benefit from extended pelvic lymph node dissection (PLND) during radical prostatectomy in a recent randomized controlled trial. We evaluated early survival outcome in contemporary patients with limited to high-risk prostate cancer (PCa) using propensity score (PS)-matched analysis.Materials and Methods: Three-hundred and forty-seven patients with high-risk PCa were enrolled. They were determined to have a lymph node (LN) involvement probability of greater than 5%. Biochemical recurrence (BCR)-free survival was compared between two groups divided by adherence with extended template and timeframe related to improving PLND procedure.Results: The mean LN yield was 23.4 and 2.7, and the positive LN rate was 19.3 and 2.0% in the extended PLND and other groups, respectively. In the entire unmatched cohort, the estimated curve was 13.1% superior in 3-year BCR-free survival for the extended PLND group. The PS-matched cohort was converged in each LN yield group to 99 patients, and the difference in the 3-year BCR-free survival widened to 22.2% (hazard ratio 0.46, 95% confidence interval 0.27-0.80; p=0.005). The statistical difference was consistent in standard high-risk PCa, and was a significant trend in very high-risk PCa. In the analysis of two groups divided by timeframe, the difference in the BCR-free survival was a significant trend.Conclusion: The results possibly demonstrate the therapeutic role of extended PLND in high-risk PCa. Statistical demonstration of benefits depends on the quality of extended PLND and whether the study cohort is the optimal composition of cancer risk.
Mesenchymal stem cells transplantation combined with IronQ attenuates ICH-induced inflammation response via Mincle/Syk signaling pathway
Authors: Yang Guoqiang , Kantapan Jiraporn , Mazhar Maryam , Bai Xue , Zou Yuanxia , Wang Honglian , Huang Bingfeng , Yang Sijing , Dechsupa Nathupakorn , Wang Li 
Published: August 2022

Abstract
Background
Cerebral edema, inflammation, and subsequent neurological defecit, are the common consequences of intracerebral hemorrhage (ICH). Mesenchymal stem cells (MSCs) transplantation had been used as a neuroprotective therapy in nervous system diseases because of its anti-inflammatory effect. However, the survival, viability, and efficacy of MSCs are limited due to the severe inflammatory response after ICH. Therefore, ways to improve the survival and viability of MSCs will provide a hopeful therapeutic efficacy for ICH. Notably, the metal-quercetin complex via coordination chemistry has been verified positively and studied extensively for biomedical applications, including growth-promoting and imaging probes. Previous studies have shown that the iron-quercetin complex (IronQ) has excellent dual functions with a stimulating agent of cell growth and an imaging probe for magnetic resonance imaging (MRI). Therefore, we hypothesized that IronQ could improve the survival and viability of MSCs, displaying the anti-inflammation function in the treatment of ICH, while also label MSCs for their tracking by MRI. This study was designed to investigate the effects of the combined treatment of MSCs with IronQ on inflammation and elucidate their underlying mechanisms.
Methods
A collagenase I-induced ICH mice model was extablished, which were randomly divided into model group (Model), quercetin gavage group (Quercetin), MSCs transplantation group (MSCs), and MSCs transplantation combined with IronQ group (MSCs + IronQ). Then the neurological deficits score, brain water content (BWC), and the protein expression levels of IL-6, TNF-α, NeuN, MBP, and GFAP were investigated. We measured the protein expression levels of Mincle and its downstream targets. Furthermore, the lipopolysaccharide (LPS)-induced BV2 cells was used to investigate the neuroprotection of conditioned medium of MSCs co-cultured IronQ in vitro.
Results
We found that the combined treatment improves the inflammation-induced neurological function and BWC by inhibiting the Mincle/Syk signaling pathway in vivo. The conditioned medium of MSCs co-cultured with IronQ decreased inflammation, the protein expression levels of Mincle, and its downstream targets in LPS-induced BV2 cell line.
Conclusions
These data suggested that the combined treatment plays a synergistic role in ameliorating the consequences of ICH, including neurologic deficits, brain edema, and inflammatory response through the downregulation of the Mincle/syk signaling pathway.
Knowledge and attitude regarding monkeypox virus among physicians in Saudi Arabia, a cross-sectional study
Authors: Alshahrani Najim Z. , Algethami Mohammed R. , Alarifi Abdullah M , Alzahrani Faris , Sheerah Haytham Abdulwhab , Abdelaal Abdelaziz , Sah Ranjit , Rodriguez-Morales Alfonso J. 
Published: August 2022

Abstract
Objectives
The aim of this study was to assess the knowledge and attitudes towards monkeypox infection among physicians, a frontline healthcare worker group, in Saudi Arabia.
Methods
A cross-sectional, online survey assessing knowledge and attitudes towards monkeypox infection on multiple-item scales was sent to physicians in Saudi Arabia. The associations between independent factors and either knowledge or attitude were assessed.
Results
The final analysis included 398 participants. Approximately 57% of the participants were under 30 years old, and 56.8% were male. Only 18.6% of the surveyed participants had ever received information about monkeypox in their medical education. A substantial proportion of assessed physicians lack knowledge regarding the endemicity of monkeypox, its transmission, clinical differences with smallpox, chickenpox, and influenza, as well as the clinical evolution and the main associated findings. In addition, there is a significant knowledge gap between the therapeutic management of monkeypox and its vaccination. Such poor knowledge is influenced by various factors.
Conclusions
Physicians' knowledge and attitudes regarding monkeypox infection are inadequate. Training and knowledge assessment is important, as demonstrated by previous epidemics and pandemics such as Zika and COVID-19, especially when studies show significant improvement in related and specific knowledge.
Host blood-based biosignatures for subclinical TB and incipient TB: a prospective study of adult TB household contacts in Southern India.
Authors: Sivakumaran Dhanasekaran , Jenum Synne , Srivast Aashish , Steen Vidar M , Vaz Mario , Doherty Timothy Mark , Ritz Christian , Grewal Harleen M.S. 
Published: August 2022

Abstract
Background A large proportion of the global tuberculosis (TB) burden is asymptomatic and not detectable by symptom-based screening, driving the TB epidemic through continued M. tuberculosis transmission. Currently, no validated tools exist to diagnose incipient and subclinical TB. Methods Nested within a large prospective study in household contacts of pulmonary TB cases in Southern India, we assessed 35 incipient TB and 12 subclinical TB cases, along with corresponding household active TB cases (n=11), and household controls (n=39) using high throughput methods for transcriptional and protein profiling. We split the data into training and test sets and applied a support vector machine classifier followed by a Lasso regression model to identify signatures. Results The Lasso regression model identified an 11-gene signature (ABLIM2, C20orf197, CTC-543D15.3, CTD-2503O16.3, HLADRB3, METRNL, RAB11B-AS1, RP4-614C10.2, RNA5SP345, RSU1P1, and UACA) that distinguished subclinical TB from incipient TB with an AUC of 1.00 (95% CI: 0.99 – 1.00), corresponding to a sensitivity of 100.0% (95%CI, 63.1-100.0), specificity of 100.0% (95%CI, 85.2-100.0) and the AUC of 0.90 (95% CI: 0.74 – 1.00), and a sensitivity of 100.0% (95%CI, 39.8-100.0), specificity of 83.3% (95%CI, 51.6-97.9) in the training and test sets, respectively. Further, we identified an 8-protein signature comprising b-FGF, IFNγ, IL1RA, IL7, IL12p70, IL13, PDGF-BB, and VEGF that differentiated subclinical TB from incipient TBs with an AUC of 1.00 (95%CI, 0.99-1.00) and an AUC of 0.75 (95%CI, 0.50-0.99) in the training and test set, respectively. Conclusions The 11-gene signature identified in this study in a population with different genetic and socioeconomic settings with lower TB incidence could also be useful for predicting TB progression. However, validation in other studies is warranted to establish the potential of the immune biosignatures for identifying subclinical TB.
Phase III study of HR-positive/HER2-negative/lymph node-positive breast cancer non-responsive to primary chemotherapy: a randomized clinical trial
Authors: Ouyang Tao , Yang Yang , He Yingjian , Fan Zhaoqing , Chen Xue , Liu Yiqiang , Zhang Chao , Jiang Hongchuan , Wang Xin , Wang Xiang , Xie Fei , Wang Shu , Luo Bin , Kang Hua , Wang Tao , Jiang Zefei , Yuan Peng , Xu Binhe , Xu Ling , Liu Yinhua , Li Jinfeng , Xie Yuntao , Wang Tianfeng 
Published: August 2022

Abstract
A multi-center, open-label, randomized, controlled phase III trial was conducted to evaluate pathological response-guided non-cross-resistant adjuvant chemotherapy in patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-)/lymph node-positive (LN+) breast cancer who were non-responsive to primary chemotherapy. Patients received four cycles of non-cross-resistant adjuvant chemotherapy plus endocrine therapy (ET), or ET alone. Forty patients responsive to neoadjuvant chemotherapy and with Miller and Payne G4 or G5 and LN − status were assigned to the observation group. Distant disease-free survival was the primary endpoint. The final intention-to-treat analysis comprised 379 patients. After a median follow-up period of 72.4 months, the 5-year distant disease-free survival was 92% and 90% in the chemotherapy plus ET and ET-alone groups, respectively. Comparatively, the observation group showed a trend towards better distant disease-free survival. For patients non-responsive to neoadjuvant chemotherapy, adjuvant non-cross-resistant chemotherapy did not significantly improve distant disease-free survival compared to ET alone. Trial registration: The trial was registered on November 25, 2009, at ClinicalTrials.gov, and the registration number was NCT01019616. https://clinicaltrials.gov/ct2/show/NCT01019616?term=alternative+non-cross-resistant&draw=2&rank=1
Influence of soil organic carbon, water holding capacity and moisture content on heavy metals in rice paddy soils of Western Ghats of India
Authors: Hegade Ranjana Ramesha , MV Chethana Kumara , SV Krishnamurthy 
Published: August 2022

Abstract
Analysis of soil samples collected from 16 rice paddy fields located in Western Ghats region was made to quantify the heavy metals concentration. Heavy metal analysis was done for Cu, Zn, Mn, Fe, Ni, Cr, Cd, and Pb using atomic absorption spectroscopy. High concentration of these heavy metals was found in rice paddy fields regularly being cultivated using agrochemicals. We compared this concentration with soils of rice paddy field that was not under cultivation. Cu, Zn, Mn, Fe, Cr, Ni, Pb, and Cd showed a build up at an order of 1.2, 1.3, 2.3, 2.2, 1.8, 2.8, 1.8, and 8.5 times higher in the rice paddy fields cultivated with agrochemical applications. Heavy metals exhibited maximum association (PCA) with soil moisture content (Zn, Fe, Cr, Ni, and Cd), organic carbon content (Fe, Cr, Ni, and Cd) and water holding capacity (Cu, Pb, and Cd). Such associations were absent in the reference site. This indicates the build-up of heavy metals in rice paddy soils under the strong influence of moisture content, water holding capacity, and organic carbon content of the soil.
Study of knowledge, attitude and anxiety in Kurdistan-region of Iraqi population during the monkeypox outbreak in 2022
Authors: Ahmed Sirwan Khalid , Abdulqadirb Salar Omar , Omar Rukhsar Muhammad , Essa Rawand Abdulrahman , Hussein Safin Hassan , Khdir Awat Alla , Abdulla Araz Qadir 
Published: August 2022

Abstract
On July 23, the WHO declared the rapidly spreading monkeypox epidemic a Public Health Emergency of International Concern (PHEIC). This study attempted to assess the knowledge, attitude, and anxiety levels of the general population during the monkeypox outbreak. An online cross-sectional survey was conducted during the period July 27 and July 30, 2022, using a convenience sampling method. The questionnaire was adapted and developed after an in-depth review of the previous studies. A total of 510 respondents participated in this study. 277 (54.3%) were male, 233 (45.7%) were female. Participants had insufficient knowledge of MPX with a mean and SD deviation 2.096 ± 1.359, 2.576 ± 1.466, having a normal attitude toward MPX 4.031 ± 1.645. Moreover, they had anxiety problems 32.382 ± 10.094. There were significant differences in the mean rank scores of the knowledge of respondents about MPX according to their gender, marital status, religion, level of education, and place of residence, with p-values of 0.009, 0.000, 0.000, 0.000, and 0.000, respectively. Also, there were significant differences in the mean rank scores of attitudes of respondents toward MPX according to their gender, level of education, place of residence, and age, with p-values of 0.011, 0.020, and 0.000, 0,029, respectively. Lastly, there were significant differences in the mean rank score of anxiety of respondents toward MPX according to their gender, marital status, religion, level of education, and place of residence, with p-values of 0.000, 0.009, 0.000, 0.000, and 0.000 respectively. There is an urgent need to raise public awareness and manage people's emotional wellbeing.