bluuebunny/crossref_metadata_2025_split huggingface dataset:
Late-Onset Sepsis Among Very Preterm Infants
Authors: Flannery Dustin D. , Edwards Erika M. , Coggins Sarah A. , Horbar Jeffrey D. , Puopolo Karen M. 
Published: November 2022

OBJECTIVES
To determine the epidemiology, microbiology, and associated outcomes of late-onset sepsis among very preterm infants using a large and nationally representative cohort of NICUs across the United States.

METHODS
Prospective observational study of very preterm infants born 401 to 1500 g and/or 22 to 29 weeks’ gestational age (GA) from January 1, 2018, to December 31, 2020, who survived &gt;3 days in 774 participating Vermont Oxford Network centers. Late-onset sepsis was defined as isolation of a pathogenic bacteria from blood and/or cerebrospinal fluid, or fungi from blood, obtained &gt;3 days after birth. Demographics, clinical characteristics, and outcomes were compared between infants with and without late-onset sepsis.

RESULTS
Of 118 650 infants, 10 501 (8.9%) had late-onset sepsis for an incidence rate of 88.5 per 1000 (99% confidence interval [CI] [86.4–90.7]). Incidence was highest for infants born ≤23 weeks GA (322.0 per 1000, 99% CI [306.3–338.1]). The most common pathogens were coagulase negative staphylococci (29.3%) and Staphylococcus aureus (23.0%), but 34 different pathogens were identified. Infected infants had lower survival (adjusted risk ratio [aRR] 0.89, 95% CI [0.87–0.90]) and increased risks of home oxygen (aRR 1.32, 95% CI [1.26–1.38]), tracheostomy (aRR 2.88, 95% CI [2.47–3.37]), and gastrostomy (aRR 2.09, 95% CI [1.93–2.57]) among survivors.

CONCLUSIONS
A substantial proportion of very preterm infants continue to suffer late-onset sepsis, particularly those born at the lowest GAs. Infected infants had higher mortality, and survivors had increased risks of technology-dependent chronic morbidities. The persistent burden and diverse microbiology of late-onset sepsis among very preterm infants underscore the need for innovative and potentially organism-specific prevention strategies.
COVID-19 in elderly: Correlations of viral load, clinical course, laboratory parameters, among patients vaccinated with CoronaVac
Authors: Altintop Sabri Engin , Unalan-Altintop Tugce , Cihangiroglu Mustafa , Onarer Pelin , Milletli-Sezgin Fikriye , Gozukara Melih , Gozukara Bilge , Zengin Erman 
Published: November 2022

AbstractSARS-CoV-2 virus was initially identified in Wuhan, China, in December 2019 and a global pandemic was declared in March 2020 by World Health Organization. COVID-19 disease is characterized with severe pneumonia and hypoxemia, especially in the elderly population. The elderly population was primarily vaccinated with CoronaVac, which is a whole virion inactivated vaccine (Sinovac Biotech, China) in Turkey. This study aimed to investigate the association of viral load and laboratory parameters with the severity of the disease and vaccination status in elderly (older than 60 years old) COVID-19 patients. The age range of the patients was 61–97 years old with a mean of 71.80. Vaccinated patients had a lower viral load (P = 0.253) in nasopharyngeal swabs during breakthrough COVID-19 infection compared to unvaccinated ones and were hospitalized for a shorter period of time in hospital wards (P = 0.035). A lower number of patients were vaccinated in both moderate (n = 33, 29.20%) and severe/critical group (n = 46, 34.07%) (P = 0.412). Only 17 (32.08%) vaccinated patients were hospitalized in an intensive care unit (ICU), whereas 36 (67.92%) of the ICU patients were unvaccinated (P = 0.931). Severe/critical patients had higher c-reactive protein (CRP), platelet-to-lymphocyte ratio (PLR), fibrinogen, ferritin, and lactate dehydrogenase (LDH) levels compared to the moderate group on the admission day (P < 0.05). Our study suggested that elderly patients vaccinated with CoronaVac had a shorter stay in hospitals and according to our results CRP, PLR, fibrinogen, ferritin, and LDH levels could be used to determine the severity of the infections.
Constructivism in language pedagogy
Authors: Szabó Fruzsina , Csépes Ildikó 
Published: November 2022

AbstractThis paper highlights the concept of constructivism that underpins the theory and practice of foreign language teaching. The dominance of this pedagogical movement in the second half of the 20th century and the beginning of the 21st century has been particularly important for the study and understanding of digitally supported forms of learning. Constructivism can provide a response to the analysis and practice of new forms of learning: it is based on the premise that knowledge transfer and the role of the teacher are undergoing intense change. Its implications in the classroom define and influence the pedagogical models and traditions of our time. The paper traces the emergence and dimensions of constructivism in today's digitally infused education, providing a theoretical and literature overview.
National Projections for Clinical Implications of Race-Free Creatinine-Based GFR Estimating Equations
Authors: Diao James A. , Wu Gloria J. , Wang Jason K. , Kohane Isaac S. , Taylor Herman A. , Tighiouart Hocine , Levey Andrew S. , Inker Lesley A. , Powe Neil R. , Manrai Arjun K. 
Published: November 2022

Significance Statement
A national task force convened by the NKF-ASN recently recommended a new race-free creatinine equation for calculating eGFR. Although this equation is expected to be widely adopted, its broad effect on recommended clinical care across the eGFR spectrum and across different racial and ethnic groups is not known. The authors used nationally representative data from 44,360 participants in NHANES to quantify expected changes to recommended care. They found that nationwide implementation of the new creatinine-based eGFR equation may affect recommended care for hundreds of thousands of Black adults and millions of non-Black adults, including new CKD diagnoses and reversals, CKD stage reclassifications, and changes in kidney donation eligibility, nephrologist referral, and medication dosing.

Background
The National Kidney Foundation and American Society of Nephrology Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease recently recommended a new race-free creatinine-based equation for eGFR. The effect on recommended clinical care across race and ethnicity groups is unknown.

Methods
We analyzed nationally representative cross-sectional questionnaires and medical examinations from 44,360 participants collected between 2001 and 2018 by the National Health and Nutrition Examination Survey. We quantified the number and proportion of Black, White, Hispanic, and Asian/Other adults with guideline-recommended changes in care.

Results
The new equation, if applied nationally, could assign new CKD diagnoses to 434,000 (95% confidence interval [CI], 350,000 to 517,000) Black adults, reclassify 584,000 (95% CI, 508,000 to 667,000) to more advanced stages of CKD, restrict kidney donation eligibility for 246,000 (95% CI, 189,000 to 303,000), expand nephrologist referrals for 41,800 (95% CI, 19,800 to 63,800), and reduce medication dosing for 222,000 (95% CI, 169,000 to 275,000). Among non-Black adults, these changes may undo CKD diagnoses for 5.51 million (95% CI, 4.86 million to 6.16 million), reclassify 4.59 million (95% CI, 4.28 million to 4.92 million) to less advanced stages of CKD, expand kidney donation eligibility for 3.96 million (95% CI, 3.46 million to 4.46 million), reverse nephrologist referral for 75,800 (95% CI, 35,400 to 116,000), and reverse medication dose reductions for 1.47 million (95% CI, 1.22 million to 1.73 million). The racial and ethnic mix of the populations used to develop eGFR equations has a substantial effect on potential care changes.

Conclusion
The newly recommended 2021 CKD-EPI creatinine-based eGFR equation may result in substantial changes to recommended care for US patients of all racial and ethnic groups.
Repercussões da covid-19 para a saúde de adolescentes
Authors: Souza Jeane Barros de , Brum Crhis Netto de , Potrich Tassiana , Zuge Samuel Spiegelberg , Lago Ana Lucia , Vitalle Maria Sylvia de Souza 
Published: November 2022

Objetivo: compreender as repercussões da pandemia da Coronavirus Disease 2019 para a saúde do adolescente. Método: estudo qualitativo, do tipo ação-participante, fundamentado nos pressupostos de Paulo Freire. Realizou-se um Círculo de Cultura Virtual, com a participação de 11 adolescentes, sendo percorrido as etapas do Itinerário de Pesquisa: Investigação Temática; Codificação e Descodificação e Desvelamento Crítico. Resultados: emergiram dois temas geradores: “A Coronavirus Disease 2019 na adolescência: transformações do presente” e “Como será o amanhã?” Discutiu-se sobre a necessidade de ficar somente em casa, sem ir à escola e nem ver os amigos. Também refletiram sobre o futuro, demonstrando insegurança e preocupação com a situação da família e a valorização do que é importante na vida. Conclusão: A necessidade do afastamento social ou, alguns casos, do isolamento social, impostas pela pandemia, resultaram em mudanças bruscas na rotina dos adolescentes e de todo o grupo familiar.
Практична мудрість для системних трансформацій у соціальній політиці України доби Ковіду-19
Authors: Василець Ольга , Ісоян Артьом 
Published: November 2022

Ефективність політичних впроваджень визначається, перш за все, відповідністю дій з боку найбільш активних та залучених до управління соціальних акторів до потреб (запитів) суспільства, релевантністю ідеологічного підґрунтя як чиннику забезпечення реалізації цих політичних впроваджень. До сучасних ідеологічних течій необхідно залучити концепцію фронезиса, як практичної мудрості, що допомагає ефективно діяти у різних умовах, враховуючи різноманітні чинники у динаміці повсякденних проблем...
Ethics in the organization of work of public authorities in Ukraine
Authors: Yevtushenko Olga 
Published: November 2022

At the present stage of modernization of state power and development of Ukraine the role of ethics and rules of conduct for public servants are important factors that must ensure the proper functioning of public authorities. Today, it is not enough to be a professionally trained employee for effective performance of state and regional tasks, to have the necessary knowledge and sufficient work experience; it is also necessary to be able to establish business relations with consumers of management services and to avoid prejudgment or excess of official powers, and it is only possible only on condition of constant observance of rules of ethical behavior, availability of public servants and officials of local self-government of stable ethical beliefs, understanding of principles, understanding ability to act in good faith. In the people’s imagination, a public servant is not an ordinary specialist; it is a person who acts within the limits of the powers conferred on him on behalf of the state or territorial community...
Faktor-Faktor yang Mempengaruhi Kepatuhan Wajib Pajak Reklame di DKI Jakarta
Authors: Siti Farhah  , Indra Pahala  , Indah Muliasari  
Published: November 2022

Penelitian ini bertujuan untuk mengetahui adanya pengaruh dari kualitas pelayanan, kondisi keuangan, sanksi perpajakan dan kompleksitas peraturan terhadap kepatuhan wajib pajak reklame. Populasi pada penelitian ini adalah wajib pajak reklame yang terdaftar di Badan Pendapatan Daerah (Bapenda). Metode pengambilan sampel dalam penelitian ini menggunakan teknik Simple random sampling. Sampel pada penelitian ini yaitu 104 wajib pajak reklame. Analisis yang digunakan adalah analisis regresi linier berganda dengan menggunakan bantuan aplikasi SPSS 23.
Penelitian ini memperolah hasil sebagai berikut: Kualitas Pelayanan berpengaruh positif terhadap kepatuhan wajib pajak reklame, Kondisi Keuangan tidak berpengaruh terhadap kepatuhan wajib pajak reklame, Sanksi Perpajakan berpengaruh positif terhadap kepatuhan wajib pajak reklame dan Kompleksitas Peraturan berpengaruh positif terhadap kepatuhan wajib pajak reklame.
Pengaruh Arus Kas Operasi, Pengeluaran Modal, Rasio Perputaran Aktiva Tetap, Time Interest Earned Rasio dan Return on Asset Ratio Terhadap Pertumbuhan Laba Pada Perusahaan Non Keuangan di Masa Pandemi Covid-19
Authors: Oktavia Ayu Wiyanti  , I Gusti Ketut Agung Ulupui  , Dwi Kismayanti Respati  
Published: November 2022

Penelitian ini bertujuan untuk mengetahui pengaruh Arus Kas, Pengeluaran Modal, Rasio Perputaran Aktiva Tetap, Time Interest Earned dan Return on Asset Terhadap Pertumbuhan Laba. Penelitian ini dilakukan dengan populasi seluruh Perusahaan Non Keuangan Yang Terdaftar Di Bursa Efek Indonesia dimasa Pandemik Covid-19 ditahun 2020. Dengan penentuan sampel mengunakan metode nonprobabilitas yaitu purposive sampling. Data yang digunakan dalam penelitian ini merupakan data sekunder dan dilakukan analisis melalui regresi linier berganda. Dengan hasil penelitian menunjukan bahwa pengeluaran modal, time interest earned dan return on asset memiliki pengaruh signifikan positif terhadap pertumbuhan laba. Sedangkan arus kas operasi, perputaran aktiva tetap dan tidak memiliki pengaruh signifikan yang positif terhadap pertumbuhan laba. Dan secara simultan semua variabel independent, berpengaruh signifikan terhadap pertumbuhan laba.
Analisis Pengaruh Self-Efficacy, Pengetahuan Auditor dalam Mendeteksi Kekeliruan, dan Tekanan Ketaatan Terhadap Audit Judgment
Authors: Sintha Rumondang  , Adam Zakaria  , Diena Noviarini  
Published: November 2022

Penelitian ini dilakukan dengan tujuan untuk memperoleh bukti empiris mengenai Analisis Pengaruh Self-Efficacy, Pengetahuan Auditor dalam Mendeteksi Kekeliruan, dan Tekanan Ketaatan terhadap Pemberian Audit Judgment. Penelitian ini menggunakan data primer dengan sampel Auditor yang bekerja pada Kantor Akuntan Publik (KAP) DKI Jakarta diwilayah Jakarta Timur , yang terdaftar dalam Directory Institut Akuntan Publik Indonesia (IAPI) periode 2021. Teknik sampling pada penelitian ini menggunakan convenience sampling dengan 62 responden. Pengujian hipotesis dalam penelitian ini menggunakan model regresi berganda dengan menggunakan SPSS 25.
Berdasarkan hasil dari analisis pada penelitian ini, dapat disimpulkan bahwa : (1) self-efficacy memiliki pengaruh positif signifikan terhadap audit judgment, (2) pengetahuan auditor dalam mendeteksi kekeliruan memiliki pengaruh positif signifikan terhadap audit judgment, dan (3) tekanan ketaatan tidak memiliki pengaruh terhadap audit judgment.
Change we can believe in: A randomised controlled trial evaluation of a vitality training employing behaviour-change techniques
Authors: Plant Bernice R. C. , Leeuwen Mattheis L. van , Peters Pascale , Heijden Beatrice I. J. M. 
Published: November 2022

Abstract
Background

This paper reports on the effects of a nine-week vitality training that employed behaviour-change techniques and was evaluated using a randomised controlled trial (RCT) in three large companies based in the Netherlands.

Method.

A total of 84 adult employees from three participating organisations in The Netherlands were enrolled in the study. A parallel group RCT design was used and participants were assigned using individual random assignment to either an intervention (n = 38) or a wait-list control group (n = 46). The intervention consisted of a nine-week vitality training employing the behaviour-change techniques of self-persuasion, implementation intentions and self-efficacy, which was delivered in-house over five fortnightly two-hour sessions. Primary outcomes (reported energy and stress) and secondary outcomes (reported daily life satisfaction and work capacity) were assessed prior to, immediately after, and three months following the intervention.

Results.

A doubly MANOVA revealed a significant interaction effect between treatment group and time period for the combination of reported energy, stress, daily life satisfaction, and work capacity. Subsequent univariate ANOVAs revealed significant interactions between treatment group and time period for reported energy, stress, and daily life satisfaction; however, not for reported work capacity. Improvements in outcomes were observed for both groups following their completion of the vitality training; however, not all improvements reached statistical significance. Reported self-efficacy regarding managing one’s work-life balance was found to mediate the relationship between the effects of the intervention and reported energy; however, such an effect was not found for stress.

Conclusions.

An intervention drawing upon evidence-based behaviour-change techniques shows promise for improving indicators associated with burnout; although, it is recommended that in future research a larger-scale evaluation be conducted over a longer time period with an active control group to establish effectiveness.
This research was retrospectively registered as a trial (UTN: U1111-1282-1116) on the Australian and New Zealand Clinical Trials Registry (ANZCTR) (Trial registration number: ACTRN12622001268730, registration date: 26/09/2022).
Optimization model for designing reliable supply chain network using drones in last-mile delivery under uncertainties
Authors: Tolooie Ali , Sinha Ashesh 
Published: November 2022

Abstract
Land transportation is generally considered one of the most expensive, polluting and least efficient parts of the logistics chain. Due to these issues, using unmanned aerial vehicles such as drones for package delivery in last-mile logistics becomes increasingly attractive. However, there are several significant obstacles in terms of technical aspects and performance capabilities of drones like limited flight coverage. In addition, supply chains are exposed to a broad range of uncertainties some of which may cause disruptions in the whole supply chain system. To hedge against these issues, a well-designed reliable network is a top priority. This research aims to construct a feasible delivery network consisting of warehouses and recharging stations through the development of a stochastic mixed-integer model, resulting in improving the coverage and reliability of the supply chain network. Due to the computational complexity of the scenario-based mixed-integer model, this research improves the performance of the genetic algorithm by considering each scenario independently in one of the steps of the algorithm to significantly improve the computational time need to find the solutions. Computational results demonstrate that the proposed algorithm is efficiently capable of solving large-scale problems. It is also demonstrated that substantial improvements in the reliability of the system can often be possible with minimal increases in facility cost.
Psychometric Properties of an Arabic Translation of the Multidimensional Social Support Scale (MSPSS) in a community sample of Lebanese Adults
Authors: Fekih-Romdhane Feten , Fawaz Mirna , Hallit Rabih , Sawma Toni , Obeid Sahar , Hallit Souheil 
Published: November 2022

Abstract
Background
There is a lack of methodologically strong measure to assess perceived social support among Arabic-speaking populations. Our main objective was therefore to examine the psychometric properties of an Arabic translation of the Multidimensional Social Support Scale (MSPSS) in a sample of Arabic-speaking Lebanese adults from the general population.
Methods
We adopted a cross-sectional design involving 387 non-clinical Lebanese adults aged 26.17 ± 11.47 years (58.4% females). The forward and backward translation method was applied to the MSPSS scale.
Results
The Arabic MSPSS and its subscales have a high internal consistency with McDonald’s ω values between 0.94 and 0.97. Confirmatory factor analysis indicated that fit of the three-factor model was acceptable. All indices suggested that configural, metric, and scalar invariance was supported across gender. Both genders exhibited no significant difference in all MSPSS dimensions. Convergent validity was supported by showing that all three MSPSS sub-scores and total score correlated significantly and positively with resilience and posttraumatic growth scores.
Conclusion
Although further cross-cultural validations involving other Arab countries and communities are still needed, we preliminarily suggest that this scale is applicable to the broad Arabic-speaking people for the measurement of perceived social support in clinical and research contexts.
Comprehensive transcriptomic and metabolomic analyses reveal the link between ferroptosis and gut microbiota in CRC
Authors: Duan Ling , Shuai Yuxi , Fan Rui , Xia Yang , Li Chunmei , Hou Xiaoming 
Published: November 2022

Abstract
Objective
Given the high incidence rate and mortality of CRC, we constructed a high-performance early diagnosis model based on ferroptosis-related genes and explored the possible pathway between ferroptosis and intestinal microbiota metabolites.
Methods
To explore the ferroptosis genes associated with CRC, the gene expression data of GSE14297 was extracted from the GEO database. A series of difference analyses and ferroptosis correlation analyses were carried out. Cytoscape was used to optimize the PPI network, and MCODE was used to screen hub gene modules. 16S rDNA was used to analyze the intestinal flora. MetaboAnalyst 5.0 was used to analyze the correlation between metabolites and genes.
Results
Compared with normal tissues, 2959 genes were differentially expressed in CRC samples, including 2946 upregulated genes and 13 downregulated genes. 63 overlapping genes were obtained by crossing with ferroptosis genes. Further MCODE analysis showed that 15 hub genes were obtained. The ROC curve showed that the AUC value of NQO1 was 0.929, and the AUC value of the other 14 genes was 1. GO enrichment analysis showed that 15 hub modules were significantly correlated with the functions of "response to oxidative stress", "plasma membrane region" and "antioxidant activity". KEGG pathway analysis showed that ferroptosis, metabolic pathways, and pathways in cancer were enriched. Metabolite pathway analysis showed that in the CRC group, the significantly enriched pathways were neuroactive ligand-receptor interaction, ABC transporters, aminoacyl tRNA biosynthesis, cocaine addition, central carbon metabolism in cancer, information processing, phenylalanine metabolism, and biosynthesis of amino acids. Analysis based on metaboanalyst5.0 showed that 25 differential metabolites were associated with ferroptosis-related genes.
Conclusion
Based on bioinformatics and 16S rDNA analysis, 25 differential metabolites were found to be associated with ferroptosis-related genes. Ferroptosis-related genes and gut microbes may jointly participate in the progression of CRC.
An atlas of genetic regulation and disease associations of microRNAs
Authors: Ghanbari Mohsen , Mustafa Rima , Mens Michelle , Hilten Arno van , Huang Jian , Roshchupkin Gennady , Huan Tianxiao , Broer Linda , Elliott Paul , Levy Daniel , Ikram M. Arfan , Evangelou Marina , Dehghan Abbas 
Published: November 2022

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. Identification of genetic variants influencing the transcription of miRNAs can provide an understanding of their genetic regulation and implication in human disease. Here we present genome-wide association studies of 2,083 plasma circulating miRNAs measured by next-generation sequencing in 2,178 participants of the Rotterdam Study to identify miRNA-expression quantitative trait loci (miR-eQTLs). We report 4,310 cis- and trans-miR-eQTLs for 64 miRNAs that have been replicated across independent studies. Many of these miR-eQTLs overlap with gene expression, protein, and metabolite-QTLs and with disease-associated variants. The consequences of perturbation in miRNA transcription on a wide range of clinical conditions are systematically investigated in phenome-wide association studies, with their causality tested using Mendelian randomization. Integration of genomics and miRNAs enables interrogation of the genetic architecture of miRNAs, revealing their clinical importance, and providing valuable resources for future studies of miRNAs in human disease.