bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between statin use and the prognosis of patients with acute myocardial infarction complicated with diabetes
Authors: Lu Xuehao , Zhang Luming , Li Shaojin , He Dan , Huang Tao , Lin Hongsheng , Yin Haiyan , Lyu Jun 
Published: August 2022

BackgroundType 2 diabetes leads to an increase in the prevalence of lipid abnormalities, which increases the risk of cardiovascular disease. Therefore, current guidelines generally recommend the use of moderate or high-intensity statins in patients with type 2 diabetes. There are still few studies on the overall risk benefit balance of statins for acute myocardial infarction (AMI) patients with diabetes. Compared with other types of lipid-lowering drugs, the advantage of statins for the prognosis of patients with AMI has not yet been determined. We investigated the effects of statins and non-statins on intensive care unit (ICU) and inpatient mortality in patients with AMI and diabetes.MethodsThis study retrospectively collected all patients with AMI and diabetes in the Medical Information Mart Intensive Care-IV database. We assessed ICU and in-hospital mortality rates during hospitalization in both groups. The clinical end point was in-hospital mortality and ICU mortality. Kaplan-Meier and Cox proportional-hazards regression models were applied to analyze the correlation between the two groups and the outcomes.ResultsData on 1,315 patients with AMI and diabetes were collected, among which 1,211 used statins during hospitalization. The overall in-hospital mortality of patients with AMI and diabetes was 17.2%, and the total ICU mortality was 12.6%. The in-hospital mortality was lower for the statin group than for the non-statin group (13.9% and 55.8%, respectively). Kaplan-Meier survival curves demonstrated that survival probability was higher in the statin group than in the non-statin group. In the cohort without hyperlipidemia, the statin group had lower risks of ICU death (HR = 0.12, 95% CI = 0.04–0.40) and in-hospital death (HR = 0.36, 95% CI = 0.16–0.84) compared with the non-statin group.ConclusionsStatins can significantly reduce ICU and in-hospital mortality rates in patients with AMI and diabetes. Even in the population without hyperlipidemia, statins can still reduce the mortality in patients with AMI and diabetes.
Evaluating the variability of glacial lakes in the Kyrgyz and Teskey ranges, Tien Shan
Authors: Daiyrov Mirlan , Kattel Dambaru Ballab , Narama Chiyuki , Wang Weicai 
Published: August 2022

The northern Tien Shan Mountains are one of the most hazardous areas in Kyrgyzstan due to frequent glacial lake outburst floods (GLOFs). The current status of glacial lakes in this region has not been reported in recent years. Therefore, this study investigates the variations of glacial lakes in the Kyrgyz and Teskey ranges using Sentinel-2 and PlanetScope optical satellite images from 2017 to 2019. Results confirm that there are 800 glacial lakes, of which 351 were in the Kyrgyz and 449 were in the Teskey Range. We found seasonality in the character of glacial lakes, most of which have been found to be unstable during our observation period. 242 glacial lakes showed significant variations in area. We found 46 newly emerging glacial lakes, five of which have rapidly expanded in the year since they formed, while 18 were found to have vanished. Thirteen lakes were found to be short-lived or unstable. In this study, 14 lakes showed a significant expansion of area. Such large variations in the glacial lakes are closely linked to local geomorphological conditions, local climate and glacier melt. We also identified a significant shift in the number of glacial lakes at altitudes over 3,500 m asl. It is associated with the mountain permafrost zone and variations of the glacier terminus. The current study recommends detailed investigation of glacial lakes in each season with the use of remote sensing and field surveys.
Change in phosphorus requirement with increasing grain yield for rice under saline-sodic stress in Northeast China
Authors: Wei Zhanxi , Zhang Yi , Liu Zhanfeng , Peng Mengsu , Wang Teng , Cao Ning 
Published: August 2022

It is possible to simultaneously reduce both food security and environmental impact by understanding the relation between rice (Oryza sativa L.) grain yield and phosphorus (P) uptake requirements. The goal of this study was to determine P uptake requirements and relationship of P accumulation with yield formation at different rice grain yield levels under saline-sodic stress. A database comprising measurements in 28 plots in four on-farm research station located in saline-sodic soil area during the period 2018–2019 in Jilin province of Northeast China was used for the analyses. The grain yields of rice averaged 9.0 Mg ha−1 and varied from 5.11 to 13.41 Mg ha−1. The P uptake at late growth stages (heading and maturity) of rice gradually increased with increasing grain yield levels. The P requirement for producing 1 Mg grain (Preq.) were 4.61, 4.60, and 4.21 kg Mg−1 for grain yields ranging from &lt;7.0, 8.0–9.5, and &gt;10.0 Mg ha−1, respectively. The decrease in Preq. values with increasing grain yield was mainly attributable to the increase in the harvest index from 0.25 to 0.33. A larger proportion of the P was accumulated from heading to maturity stage when grain yields were higher than 8.0 Mg ha−1. The P uptake in leaves, stems and panicles at the maturity stage gradually increased with increasing grain yield levels. The results give a contribution to rice production in saline-sodic soils, and greatly optimize P management especially in high-yielding rice systems, furtherly improving food security in the Jilin province of China.
HHLA2 predicts improved prognosis of anti-PD-1/PD-L1 immunotherapy in patients with melanoma
Authors: Huang Fu-xue , Wu Jun-wan , Cheng Xia-qin , Wang Jiu-hong , Wen Xi-zhi , Li Jing-jing , Zhang Qiong , Jiang Hang , Ding Qiu-yue , Zhu Xiao-feng , Zhang Xiao-shi , Ding Ya , Li Dan-dan 
Published: August 2022

BackgroundAs a recognized highly immunogenic tumor, immune checkpoint blockades (ICB) have been widely used as a systemic treatment option for melanoma. However, only about half of treated patients could benefit from it in Caucasians, and only about 15% in Chinese melanoma patients. Robust predictive biomarkers are needed. HHLA2, a new-found member of B7 family, is generally expressed in kinds of tumors, such as melanoma. This study focuses on illustrating the prognostic value of HHLA2 in melanoma immunotherapy and its association with tumor-infiltrating lymphocytes.MethodsHHLA2 expression in pan-cancer and the association with prognosis and immune microenvironment were identified by analyzing gene expression profiles from TCGA database with selected bioinformatics tools and methods. Tumor tissues from 81 cases with advanced and unresectable melanoma were collected for detecting HHLA2 and CD8 levels by immunohistochemistry.ResultsHHLA2 was found to be ubiquitously expressed in pan-cancer with high level and correlate with the prognosis of patients. Further comprehensive analysis from TCGA database demonstrated that the highly expressed HHLA2 was remarkably correlated with better prognosis, high infiltration status of various immune-active cells and immune activated pathways in skin cutaneous melanoma (SKCM). Moreover, immunohistochemistry (IHC) analyses of FFPE tissue from melanoma patients revealed that HHLA2 high expression was strongly related to improved response to ICB and indicated a longer progression-free survival (PFS) and overall survival (OS). Besides, HHLA2 expression was found to have a positive association with the density of CD8+ TILs.ConclusionOur findings revealed that high expression of HHLA2 has important values in predicting the response to ICB and indicating improved PFS and OS in patients with advanced and unresectable melanoma, suggesting that HHLA2 may serve as a costimulatory ligand in melanoma, which renders it as an ideal biomarker for immunotherapy.
Response to apatinib and camrelizumab combined treatment in a radioiodine refractory differentiated thyroid cancer patient resistant to prior anti-angiogenic therapy: A case report and literature review
Authors: Li Jiayi , Zhang Xin , Mu Zhuanzhuan , Sun Di , Sun Yuqing , Lin Yansong 
Published: August 2022

BackgroundPatients with radioactive iodine refractory progressive (RAIR) differentiated thyroid cancer (DTC) often developed resistance after first-line therapy. Apatinib plus camrelizumab is a therapy with promising efficacy in patients with other malignant cancers. Herein, we presented a case of progressive RAIR DTC treated with apatinib plus camrelizumab.Case presentationWe reported a 43-year-old man diagnosed as DTC with metastases in the lungs, the 7th cervical vertebra, and malignant lymph nodes mainly in the mediastinum. While initially showing disease stabilization after giving the first-line multitargeted kinase inhibitor (MKI) therapy, the patient developed progressive disease and was enrolled into a combined therapy with both apatinib and camrelizumab on November 10, 2020. Upon the first 6 months, the combination therapy showed disease control in terms of both stable structural lesions and biochemical thyroglobulin (Tg) level. Six months later, a decrease over the targeted lesions was observed and a partial response (PR) according to RECIST 1.1 criteria was finally achieved upon 12 months’ assessment, followed by the decline in serum Tg level. The main adverse event was occasional diarrhea without treatment interruption.ConclusionWe reported a case with RAIR DTC that benefited from combination immunotherapy, apatinib plus camrelizumab, after resistance from donafenib. We observed a gradually getting better efficacy and a mild and long duration of this combination therapy and hoped to provide a therapeutic choice for these patients.
High cholesterol and low triglycerides are associated with total lumbar bone mineral density among adults aged 50 years and over: The NHANES 2017–2020
Authors: Wang Peng , Chen Cong , Song Chunhao , Jia Jun , Wang Yuanhao , Mu Weidong 
Published: August 2022

BackgroundThe association between cholesterol and triglycerides with the lumbar bone mineral density (BMD) was widely investigated, but the results remained conflicting. This study aimed to investigate the relationship between total cholesterol, triglycerides, and total lumbar BMD in adults.Materials and methodsThis cross-sectional study included 1,985 individuals aged 50 years and over. The data on total cholesterol, triglycerides, total lumbar BMD, and other covariates were obtained from the National Health and Nutritional (NHANES) between 2017 and March 2020 pre-pandemic. Multivariate logistic regression models were utilized to investigate the association between cholesterol, triglycerides, and total lumbar BMD. Smooth curve fittings and generalized additive models were also used to analyze the potential non-linearity.ResultsA total of 901 men and 1,084 women with a mean age of 63.02 ± 8.72 years (age 50–80 years) were included in this study. In multivariate regression analysis, the association between cholesterol and total lumbar BMD was negative (β = −0.026, 95% CI: −0.033, −0.020). This relationship still existed after adjusted for gender and race (β = −0.018, 95% CI: −0.025, −0.012) and fully adjusted for all covariates (β = −0.022, 95% CI: −0.029, −0.015). The association between triglycerides and total lumbar BMD was positive (β = 0.024, 95% CI: 0.017, 0.031). This relationship still existed after adjusted for gender and race (β = 0.021, 95% CI: 0.015, 0.028) and fully adjusted for all covariates (β = 0.021, 95% CI: 0.014, 0.028). In threshold effect analysis, the relationship between triglycerides and total lumbar BMD was an inverted U-shaped curve with the inflection point at 2.597 mmol/L.ConclusionHigh levels of total cholesterol and relatively low levels of triglycerides are significantly associated with the total lumbar BMD in adults aged 50 years and over.
Elevated homocysteine level as an indicator for chronic kidney disease in community-dwelling middle-aged and elderly populations in Taiwan: A community-based cross-sectional study
Authors: Shih Yu-Lin , Shih Chin-Chuan , Chen Jau-Yuan 
Published: August 2022

BackgroundHyperhomocysteinemia is an important factor for endothelial cell damage and a risk factor for cardiovascular diseases. Chronic kidney disease (CKD) is recognized as a leading burden in Taiwan’s healthcare system. This study aimed to investigate the association between homocysteine levels and CKD in middle-aged and elderly adults from a community in northern Taiwan.MethodsA total of 396 middle-aged and elderly Taiwanese adults were enrolled and completed the health survey. We divided participants according to tertiles of homocysteine levels as first group (homocysteine level ≤ 11.1 μmol/L), second group (homocysteine level 11.2∼14.3 μmol/L), and third group (homocysteine level &gt; 14.3 μmol/L). CKD was defined as estimated glomerular filtration rate (eGFR) &lt; 60 (mL/min/1.73 m2) or urine albumin to creatinine ratio &gt; 30 (mg/g). Pearson correlation was calculated between eGFR and other related risk factors after adjustment for age. The risk of CKD in the second and third groups compared to that in the first group was assessed by multivariate logistic regression after adjustment for age, sex, smoking, hypertension (HTN), diabetes mellitus (DM), body mass index (BMI), dyslipidemia, and uric acid. The Youden index and receiver operating characteristic (ROC) curve were calculated for the optimized cutoff value.ResultsElevated plasma homocysteine levels were more likely to lower the eGFR and increase the prevalence of CKD. Pearson correlation showed a positive correlation between eGFR and high-density lipoprotein cholesterol, while a negative correlation was observed between homocysteine levels, waist circumference, systolic blood pressure, uric acid levels and BMI (all p &lt; 0.05). In the logistic regression analysis, the prevalence of CKD increased, as well as the homocysteine level. The odds ratio of CKD under 95% confidence interval was 2.655 (1.284–5.490) for the third group compared with the first group after adjusting for age, sex, smoking, DM, HTN, dyslipidemia, uric acid, and BMI (p = 0.008). The area under the ROC curve was 0.662, and a cutoff value of 15.15 μmol/L for the homocysteine level was obtained for detecting subjects with CKD.ConclusionOur study findings revealed that elevated homocysteine levels were significantly associated with CKD and could be used as an indicator of CKD among the middle-aged and elderly populations in Taiwan.
Identification of protein biomarkers in host cerebrospinal fluid for differential diagnosis of tuberculous meningitis and other meningitis
Authors: Huang Mailing , Ding Zeyu , Li Wensheng , Chen Weibi , Du Yadong , Jia Hongyan , Sun Qi , Du Boping , Wei Rongrong , Xing Aiying , Li Qi , Chu Naihui , Pan Liping 
Published: August 2022

Background and purposeThe diagnosis of tuberculous meningitis (TBM) is difficult due to the lack of sensitive methods. Identification of TBM-specific biomarkers in the cerebrospinal fluid (CSF) may help diagnose and improve our understanding of TBM pathogenesis.Patients and methodsOf the 112 suspected patients with TBM prospectively enrolled in the study, 32 patients with inconclusive diagnosis, non-infectious meningitis, and long-term treatment with hormones and immunosuppressants were excluded. The expression of 8 proteins in the CSF was analyzed using ELISA in 22 patients with definite TBM, 18 patients with probable TBM, and 40 patients with non-TBM.ResultsSignificant differences in the expression of 7 proteins were detected between the TBM and non-TBM groups (P &lt; 0.01). Unsupervised hierarchical clustering (UHC) analysis revealed a disease-specific profile consisting of 7 differentially expressed proteins for TBM diagnosis, with an accuracy of 82.5% (66/80). Logistic regression with forward stepwise analysis indicated that a combination of 3 biomarkers (APOE_APOAI_S100A8) showed a better ability to discriminate TBM from patients with non-TBM [area under the curve (AUC) = 0.916 (95%CI: 0.857–0.976)], with a sensitivity of 95.0% (95%CI: 83.1–99.4%) and a specificity of 77.5% (95%CI: 61.5–89.2%).ConclusionOur results confirmed the potential ability of CSF proteins to distinguish TBM from patients with non-TBM and provided a useful panel for the diagnosis of TBM.
Fetal magnetic resonance imaging in the diagnosis of spinal cord neural tube defects: A prospective study
Authors: Gao Gan , Tao Benzhang , Chen Yanyan , Yang Jiaqi , Sun Mengchun , Wang Hui , Hao Fangbin , Liu Simeng , Wang Minjie , Shang Aijia 
Published: August 2022

ObjectiveThis study aimed to evaluate the value of fetal magnetic resonance imaging (MRI) in the prenatal diagnosis of spinal neural tube defects.MethodsFrom August 2018 to January 2021, 56 fetuses with suspected spinal cord neural tube defects were treated by prenatal ultrasound in the Neurosurgery Department of the First Medical Center of the People's Liberation Army General Hospital. Fetal MRI was performed within 72 h after ultrasound diagnosis. Forty singleton fetuses were selected. Magnetic resonance examination was performed within 1 month after birth, and the diagnostic coincidence rates of prenatal ultrasound and fetal magnetic resonance examination in the prenatal diagnosis of spinal cord neural tube defects were compared and analyzed using postnatal magnetic resonance examination as the standard.ResultsThe coincidence rates of prenatal ultrasound and fetal MRI for the prenatal diagnosis of spina bifida were 71.4% (20/28) and 39.2% (11/28), respectively, and the difference was statistically significant. The coincidence rates of prenatal ultrasound and fetal MRI in the diagnosis of intraspinal lipoma were 52.6% (10/19) and 73.7% (14/19), respectively, and the difference was statistically significant.ConclusionFetal MRI has an advantage over prenatal ultrasound in detecting intraspinal lipoma. Prenatal ultrasound has an advantage over fetal MRI in detecting spina bifida.
Nutritional aspects in chronic non-cancer pain: A systematic review
Authors: Xu Lou Inmaculada , Gil-García Eugenia , Cáceres-Matos Rocío , Ali Kamran , Molina Esther 
Published: August 2022

ObjectivesChronic pain (CP) is an unpleasant emotional and sensory experience that can be accompanied by tissue damage that persists for more than 3 months. Recent studies show that certain nutritional strategies can help to improve pain, so this study is aimed to systematically review scientific evidence to understand and map the effect of the use of nutritional strategies on the presence or intensity of chronic non-cancer pain (CNCP) and the association of these nutritional aspects with the presence or intensity of CNCP.Study designA systematic review.MethodsTwo independent researchers searched for randomized clinical trials (RCTs) and observational studies that explored the relationship between nutrition and CNCP in adults from 2010 to 2020 in PubMed, Web of Science, Scopus, and Cochrane Library databases. A total of 24 studies were included, of which 20 were RCTs and 4 were observational studies. They are classified into the administration of nutritional supplements, dietary modification, and incorporation of food.ResultsOf these studies, those that have a significant effect on pain are dietary modification and the use of nutritional supplements. On the other hand, the main results from the few observational studies included in this review point to the existence of an association relationship between less pain and a ketogenic or hypocaloric diet or adherence to the Mediterranean diet.ConclusionDietary modification seems to be one plausible therapeutic option to improve and relieve CNCP. However, more research is needed in this regard to obtain better conclusions.Systematic Review Registration[www.crd.york.ac.uk/prospero], identifier [CRD42021226431].
Evaluation of biventricular longitudinal myocardial function in normal fetuses at different gestational ages using ultrasonic velocity vector imaging
Authors: Hou Min , Liu Liu , Xie Jun-Min , Duan Xiao-Jing , Lv Xiao-Lan , Li Xiao-Qing , Zhang Qin 
Published: August 2022

ObjectiveThis study aimed to evaluate biventricular myocardial function and biventricular longitudinal global myocardial function of fetuses at different gestational weeks using ultrasonic velocity vector imaging.MethodsA total of 127 pregnant women were enrolled and divided into five groups according to the gestational age of their fetuses. The velocity, strain, and strain rate of the left and right ventricles were measured, and these biventricular parameters were compared between the groups. The global parameters of the biventricular myocardium were also compared.ResultsA pairwise comparison revealed that the differences in biventricular velocity and strain rate between groups in adjacent gestational weeks were not statistically significant (P &gt; 0.05), but velocity increased with gestational age. A comparison of fetal longitudinal global myocardial parameters revealed that the global velocity, strain, and strain rate of the right ventricle were higher than those of the left ventricle, and the differences were statistically significant (P &lt; 0.05) in all groups.ConclusionThe peak velocities of the fetal left and right ventricles increased with gestational age, but the global strain and strain rate did not, suggesting that fetal myocardial function is mature and constant in the middle and late stages of pregnancy and can more reliably reflect myocardial deformation. The peak systolic velocity, global strain, and peak strain rate of the right ventricle were higher than those of the left ventricle, suggesting that the right ventricle dominates longitudinal systolic movement from the second trimester of pregnancy.
An arc multi-electrode pixel structure for improving the response speed of electrowetting displays
Authors: Lai Shufa , Tian Lixia , Shen Shitao , Yuan Dong , Tang Biao 
Published: August 2022

Electrowetting display (EWD) is a new generation of reflective display technology with low power consumption and high contrast. To improve the response speed of pixels, an arc multi-electrode pixel was proposed, and its performance was verified by using the established three-dimensional model in this paper. According to the model, the influence of the arc multi-electrode pixel structure on response speed was simulated, and the influence of a driving sequence on oil movement inside pixels were analyzed. In addition, comparative experiments of oil movement inside pixels with single-electrode and arc multi-electrode were conducted. Experimental results showed that the response time of the arc multi-electrode structure was 0.9 ms faster than the single-electrode structure in a pixel opening stage. In the pixel closing stage, the oil recovery time can be accelerated by applying a boosting voltage to the electrode corresponding to the oil accumulation area, which was 2.3 ms faster than that of the single-electrode structure.