bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Ratiometric Fluorescent Probe for Hypobromous Acid Detection in Living Cells
Authors: Zhang Jin , Liu Saiwen , Liu Changhui , Hu Yongjun , Peng Tianying , He Yiyun 
Published: October 2022

AbstractA novel ratiometric fluorescent probe HB‐2 based on benzothiazole for hypobromous acid (HBrO) was synthesized and studied. After HBrO was added to the CH3CN‐HEPES solution of the HB‐2, the probe cyclized to form a sulfimine bond, which increased the conjugated degree of the system. The fluorescence emission peak of the reaction system at 447 nm gradually decreased, while the newly generated emission peaks gradually increased at 580 nm. The ratio of the fluorescence intensity at the two wavelengths of 447 nm and 580 nm increased about 234 times. Moreover, it has successfully been used to stain and record microscopy images of 4T1 cells, and the presence of exogenous HBrO could be judged by the change of fluorescence intensity.
Dual Detection of Temperature And Chiral Amino Acid Using Triphenylamine‐Based Fluorescent Probes
Authors: Tu Yajing , Cao Jian , Zhang Meijuan , Liu Mingming , Huang Cuiping , Li Yanan , Wang Chuanxiao 
Published: October 2022

AbstractAccuracy measurement of temperature is important in day‐to‐day life and scientific research. Chiral amino acids play an irreplaceable role in medicine, biochemistry, and other fields; however, the polarity solvents do easily disturb hydrogen bond formation between chiral amino acids and fluorescence probe. Herein, a fluorescent probe Tap‐S, using triphenylamine as fluorophore, is synthesized for dual detection of temperature and enantiomers of chiral amino acids in polarity aqueous solution. The fluorescence emission of Tap‐S to the temperature has a good response in the mixed solvent of methanol and glycerin over a wide temperature range (−45 to 50 °C). The gradient thermosensitivity, accuracy and reversibility of Tap‐S to the temperature in our strategy are achieved. Tap‐S can emit yellow fluorescence in the high‐viscosity mixed solution. By taking advantage of the viscosity measurement, the restricted intramolecular rotation mechanism of Tap‐S's fluorescence emission was effectively clarified. Furthermore, the potential use of Tap‐S to selective detect L‐phenylalanine of chiral amino acids has been successfully executed in the polarity aqueous solution at the room temperature (25 °C). The complex of Tap‐S and L‐phenylalanine can inhibit the rotation of the single bond of Tap‐S inducing the fluorescence emission. This work provides a novel strategy for the studies on not only the detection of temperature but also the enantiomers of chiral amino acids.
Identification of 1,3‐Substituted Pyrazole‐Based Carboxamide Derivatives as Potent Antitubercular Agents
Authors: Baliram Gaikwad Nikhil , Kumar Sahoo Santosh , Ommi Ojaswitha , Naiyaz Ahmad Mohammad , Pathan Afroz , Kaul Grace , Nanduri Srinivas , Dasgupta Arunava , Chopra Sidharth , Madhavi Yaddanapudi Venkata 
Published: October 2022

AbstractIn recent past, repurposing and subsequent medicinal chemistry efforts on anti‐obesity drug rimonabant has successfully delivered several pyrroles and pyrazole‐based hits active against Mycobacterium tuberculosis (Mtb). Herein, we report the synthesis and biological evaluation of a new series of 1,3‐substituted pyrazole containing carboxamide derivatives as potential antitubercular (anti‐TB) agents. Preliminary screening indicated substantial potency and selectivity towards Mtb H37Rv. Lead compounds when subjected to cell viability test demonstrated low cytotoxicity. Structural optimization of the most active compound (MIC 0.06 μg/mL) led to the identification of 3‐heteroaromatic substituted pyrazole derivatives amongst which the lead compound exhibited equipotent activity (MIC 0.03 μg/mL) against both drug‐susceptible (DS) and drug‐resistant (DR) Mtb besides high selectivity index (SI>333). Further, time‐kill assay found these optimum active compounds endowed with mycobactericidal efficacy. Potent in vitro activity, high selectivity along with mycobactericidal attributes establishes lead compounds of the series as promising antimycobacterial candidates for further development.
Synthesis and Performance Testing of a BODIPY Fluorescent Probe for the Detection of Doxycycline Residues in Water Environment
Authors: Ding Lingzhi , Guo Qing , Sun Xiaolong , Hu Gaowei , Hu Jiahuan , Fan Shunwu , Fu Yongqian 
Published: October 2022

AbstractDoxycycline (DOX) has been used extensively in the control of animal diseases, which leads to its large‐scale accumulation in water and causes serious pollution problems. In this study, a BODIPY‐based fluorescent probe named DOX‐BOD was synthesized by a one‐pot method. The qualitative and quantitative detection of DOX was achieved by the specific response effect of DOX‐BOD on DOX. DOX‐BOD showed excellent performance and its fluorescence intensity decreased with the increase in DOX concentration. Besides, the detection limit was as low as 0.91 μM. The DOX detection method based on BODIPY fluorescent probe has good reproducibility and stability, and can be used for rapid and high‐sensitivity detection of DOX residues in the water environment, which is of great significance for environmental monitoring.
Mild Construction of “Midas Touch” Metal–Organic Framework‐Based Catalytic Electrodes for Highly Efficient Overall Seawater Splitting
Authors: Fan Jinli , Fu Chengyu , Liang Rikai , Lv Haiyang , Fang Chaosong , Guo Yanhui , Hao Weiju 
Published: October 2022

AbstractMild construction of highly efficient and durable practical electrodes for overall water splitting (OWS) at industrial‐grade current density is currently a significant challenge. Herein, metal–organic framework (MOF) materials are grown in situ on the surface of carbon cloth (CC) at 25 °C, and quickly “interspersed” by cobalt–boron (Co–B) via electroless plating for 30 min to obtain a highly efficient and stable CoB@MOF@CC self‐supporting electrode. Owing to the large specific surface area, abundant active sites, and porous structure, the MOF‐based CC modified by bamboo leaf‐like ultrathin CoB has remarkable electrochemical catalysis efficiency. The CoB@MOF@CC electrode exhibits excellent performance during the hydrogen evolution reaction (η10 = 57 mV, η500 = 266 mV) and oxygen evolution reaction (η10 = 209 mV, η500 = 423 mV) in alkaline simulated seawater, and is durable for 2500 h at 500 mA cm−2. The OWS performance is obviously enhanced by employing the prepared electrode, which only requires 1.49 V to achieve 10 mA cm−2 and is durable for over 360 h at industrial‐grade current densities in alkaline high‐salt, real seawater, rainwater, and urea electrolytes.
Enhanced Thermoelectric Performance in Black Phosphorene via Tunable Interlayer Twist
Authors: Duan Shuai , Cui Yangfan , Yi Wencai , Chen Xin , Yang Bingchao , Liu Xiaobing 
Published: October 2022

AbstractTwist‐angle two‐dimensional (2D) systems are attractive in their exotic and tunable properties by the formation of the moiré superlattices, allowing easy access to manipulating intrinsic electrical and thermal properties. Here, the angle‐dependent thermoelectric properties of twisted bilayer black phosphorene (tbBP) by first‐principles calculations are reported. The simulations show that significantly enhanced Seebeck coefficient and power factor can be achieved in p‐type tbBP due to merging of the multi‐valley electronic states and flat moiré bands. Moreover, the twisted layers bring in a strong anharmonic phonon scattering and thus very low lattice thermal conductivity of 4.51 W m−1 K−1 at 300 K. Consequently, a maximal ZT value can be achieved in p‐type 10.11° tbBP along the armchair direction up to 0.57 and 1.06 at 300 and 500 K, respectively. The room‐temperature ZT value along the zigzag direction is also significantly increased by almost 40 times compared to pristine BP when the twist angle is close to 70.68°. This work demonstrates a platform to manipulate thermoelectric performance in 2D materials by creating moiré patterns, leading tbBP as a promising eco‐friendly candidate for thermoelectric applications.
3D Porous Compact 1D/2D Fe2O3/MXene Composite Aerogel Film Electrodes for All‐Solid‐State Supercapacitors
Authors: Luo Yijia , Tang Yi , Bin Xiaoqing , Xia Chenji , Que Wenxiu 
Published: October 2022

Abstract2D MXene nanoflakes usually undergo serious restacking, that easily aggravates during the traditional vacuum‐assisted filtration process; and thus, hinders the electrochemical performance of the corresponding film electrodes. Herein, 3D porous compact 1D/2D Fe2O3/MXene aerogel film electrode with an enhanced electrochemical performance is fabricated by freeze‐drying assisted mechanical pressing. An introduction of 1D α‐Fe2O3 nanorods can not only alleviate the restacking of 2D MXene but also provide additional pseudocapacitance for the composite film system. Thus, the resulting Fe2O3/MXene aerogel film electrode shows an enhanced specific capacitance of 182 F g−1 (691 mF cm−2) at a current density of 1 A g−1 in 3 m H2SO4 electrolyte as well as with 81.74% capacitance retention after 10 000 charge–discharge cycles. Besides, the addition of 1D α‐Fe2O3 nanorods has a significant contribution in the volumetric capacitance of the composite aerogel film (150 F cm−3), which is 2.68 times that of the pure MXene aerogel film (56 F cm−3). Moreover, the fabricated all‐solid‐state symmetric supercapacitor (SSSC) delivers a superior areal energy density of 3.61 µWh cm−2 at a power density of 119.04 µW cm−2. This rapid‐forming 3D porous, binder‐free, and freestanding aerogel film provides a progressive strategy for the fabrication of MXene‐based electrode for supercapacitors.
Enhanced Pd/a‐WO3/VO2 Hydrogen Gas Sensor Based on VO2 Phase Transition Layer
Authors: Li Bowen , Wang Zhaowu , Zhao Shanguang , Hu Changlong , Li Liang , Liu Meiling , Zhu Jinglin , Zhou Ting , Zhang Guobin , Jiang Jun , Zou Chongwen 
Published: October 2022

AbstractThe utilization of clean hydrogen energy is becoming more feasible for the sustainable development of this society. Considering the safety issues in the hydrogen production, storage, and utilization, a sensitive hydrogen sensor for reliable detection is essential and highly important. Though various gas sensor devices are developed based on tin oxide, tungsten trioxide, or other oxides, the relatively high working temperature, unsatisfactory response time, and detection limitation still affect the extensive applications. In the current study, an amorphous tungsten trioxide (a‐WO3) layer is deposited on a phase‐change vanadium dioxide film to fabricate a phase transition controlled Pd/a‐WO3/VO2 hydrogen sensor for hydrogen detection. Results show that both the response time and sensitivity of the hydrogen sensor are improved greatly if increasing the working temperature over the transition temperature of VO2. Theoretical calculations also reveal that the charge transfer at VO2/a‐WO3 interface becomes more pronounced once the VO2 layer transforms to the metal state, which will affect the migration barrier of H atoms in a‐WO3 layer and thus improve the sensor performance. The current study not only realizes a hydrogen sensor with ultrahigh performance based on VO2 layer, but also provides some clues for designing other gas sensors with phase‐change material.
Calibrated design model for the compression capacity of angle members – Consideration of welded or bolted joint configurations
Authors: Unterweger Harald , Kettler Markus , Zauchner Paul 
Published: October 2022

AbstractDue to the commonly eccentric connection on only one angle leg (bolted or welded), additional bending moments are acting on the angle member under compression axial force, leading to a complex load‐carrying behaviour with flexural and/or flexural torsional buckling phenomena. Furthermore, type and size of rotational restraints at the member's ends (provided by the adjacent structure) significantly influence the compression capacity of these members. In this article, a recently developed design model for angle members in compression with welded or bolted end connection is presented. The design model considers the accurate rotational spring stiffness of three common joint types. The presented procedure allows for calculating the internal forces based on elastic second‐order theory for an individual member with eccentricities, equivalent geometric imperfection and rotational spring stiffness at both ends. The detailed analytical equations for the rotational spring stiffness of all studied joint configurations are summed up. In addition, calibration factors fDi are presented, to get accurate compression capacities with the design model. Finally, the accuracy of the design model for all three studied joint types of angle members with welded connections is shown through comparison with sophisticated finite element calculations, code provisions (EN 1993‐1‐1, AISC) and experimental tests from the literature.
Numerical collapse simulation based critical state analysis for framed‐wall structure subjected to earthquakes
Authors: Ibrahim Ali R. , Makhloof Doaa A. , Ren Xiaodan 
Published: October 2022

SummaryWith the rapid developments of the constitutive theory, numerical methods, and computer software and hardware, full attention has been paid to establishing nonlinear structural models and investigating the nonlinear behavior, damage performance, and failure criterion of the structures. Consequently, this study introduces a precise analysis with a highly accurate level of simulation for an existing framed‐wall structure excited with strong ground motions. The incremental dynamic analysis (IDA) technique has been adopted to investigate the nonlinear behavior of the structure. The damage evolution and collapse pattern have been well captured in the structure based on the adopted damage model. The results showed that the maximum interstory drift (ISD) position varies at different seismic loads due to the damage initiation and propagation variation. The IDA curves show the end of the elastic stage at 0.70, 0.50, 0.70, and 0.20 g at San Francisco, Italy, Northridge, and San Fernando ground motions, respectively. Also, different collapse patterns of the structure have been observed at different ground motions and also at different intensities for the same ground motion. Therefore, the high‐rise building design should account for multiple collapse patterns. Moreover, a new IDA‐based technique is proposed to estimate the structure's maximum seismic capacity (MSC) and ensure it through the collapse analysis. The structure adopted in this study reaches its MSC at the San Francisco event at an intensity of 2.50 g. However, the MSC decreased by 40% at Italy and Northridge events and 60% at the San Fernando event. Since the seismic capacity of the structure is considered an essential ingredient in the design process, therefore, the findings of this study are supposed to lay the basis for the performance‐based seismic design of the structure.
Students' engagement with Socioscientific issues: Use of sources of knowledge and attitudes
Authors: Klaver Lida T. , Walma van der Molen Juliette H. , Sins Patrick H. M. , Guérin Laurence J. F. 
Published: October 2022

AbstractThe current study is about students' engagement with socioscientific issues (SSI). We explored the use of sources of knowledge about SSI and attitudes toward SSI among a sample of 1676 Dutch 8‐ to 16‐year‐old students. First, we developed a questionnaire that measured students' use of four sources of knowledge about SSI: Social Resources (online media use and talking with parents and friends), In‐Class Resources (in‐class talk and in‐class offline media use), Visit Resources (visiting the zoo or a science museum with parents or school), and Offline Media Resources (engaging with issues or the news via books, magazines, newspapers, or TV). Second, we performed a latent profile analysis to explore students' patterns of use of these sources. This resulted in five profiles: Social Visitors (5.9%), Offline Media Consumers (10.6%), Media Discussers (14.3%), In‐Class Users (21.0%), and Non‐Users (48.3%). Third, we related these profiles to students' attitudes toward SSI, as measured with the Pupils' Attitudes toward Socioscientific Issues (PASSI) questionnaire. In line with the sources of knowledge profiles, the Non‐Users felt and thought most negatively about engagement with SSI, while the Media Discussers showed the most positive attitudes. We believe that our exploration of the profiles adds to the discourse about students' socioscientific capital. Moreover, this study informs teachers about the resources that students may bring into the learning environment and their decision‐making about SSI. The study concludes with practical suggestions about stimulating the use of sources of knowledge for certain groups of students and fostering positive attitudes toward engagement with SSI.
PI3K/AKT/mTOR pathway mediated‐cell cycle dysregulation contribute to malignant proliferation of mouse spermatogonia induced by microcystin‐leucine arginine
Authors: Du Xingde , Liu Haohao , Tian Zhihui , Zhang Shiyu , Shi Linjia , Wang Yongshui , Guo Xing , Zhang Bingyu , Yuan Shumeng , Zeng Xin , Zhang Huizhen 
Published: October 2022

AbstractEnvironmental cyanotoxin exposure may be a trigger of testicular cancer. Activation of PI3K/AKT/mTOR signaling pathway is the critical molecular event in testicular carcinogenesis. As a widespread cyanotoxin, microcystin‐leucine arginine (MC‐LR) is known to induce cell malignant transformation and tumorigenesis. However, the effects of MC‐LR on the regulatory mechanism of PI3K/AKT/mTOR pathway in seminoma, the most common testicular tumor, are unknown. In this study, mouse spermatogonia cell line (GC‐1) and nude mice were used to investigate the effects and mechanisms of MC‐LR on the malignant transformation of spermatogonia by nude mouse tumorigenesis assay, cell migration invasion assay, western blot, and cell cycle assay, and so forth. The results showed that, after continuous exposure to environmentally relevant concentrations of MC‐LR (20 nM) for 35 generations, the proliferation, migration, and invasion abilities of GC‐1 cells were increased by 120%, 340%, and 370%, respectively. In nude mice, MC‐LR‐treated GC‐1 cells formed tumors with significantly greater volume (0.998 ± 0.768 cm3) and weight (0.637 ± 0.406 g) than the control group (0.067 ± 0.039 cm3; 0.094 ± 0.087 g) (P < .05). Furthermore, PI3K inhibitor Wortmannin inhibited the PI3K/AKT/mTOR pathway and its downstream proteins (c‐MYC, CDK4, CCND1, and MMP14) activated by MC‐LR. Blocking PI3K alleviated MC‐LR‐induced cell cycle disorder and malignant proliferation, migration and invasive of GC‐1 cells. Altogether, our findings suggest that MC‐LR can induce malignant transformation of mouse spermatogonia, and the PI3K/AKT/mTOR pathway‐mediated cell cycle dysregulation may be an important target for malignant proliferation. This study provides clues to further reveal the etiology and pathogenesis of seminoma.
Choline alleviated perinatal fluoride exposure‐induced learning and memory impairment through α4β2 nAChRs and α7 nAChRs in offspring mice
Authors: Zhao Yangfei , Zhao Xiaojuan , Wang Jundong 
Published: October 2022

AbstractFluoride pollution is widely present in the living environment. As a critical period of brain development, the perinatal period is extremely vulnerable to fluoride. Studies have found that choline can protect the brain's memory and enhance the ability to focus. However, the effect of choline on perinatal fluoride‐induced nerve damage remains unclear. Therefore, 32 Kunming newly conceived female mice and their offspring mice were randomly divided into control, NaF, LC + NaF, and HC + NaF groups, and the HE staining, Y‐maze test, RT‐PCR, western blotting, immunohistochemistry, etc. were used in this study. The results showed that fluoride decreased the brain organ coefficients and brain protein content (p < 0.05, p < 0.01), and caused histomorphological damage in the hippocampus and cortex, which suggested that fluoride affected the development of the brain and damaged the brain. Moreover, the results of the Y‐maze test showed that fluoride increased the number of learning days, error reaction time, and total reaction time, and decreased the AchE activity in the brain (p < 0.05, p < 0.01), which indicated that fluoride reduced the learning and memory ability of the mice. Besides, the results showed that fluoride decreased the mRNA and protein expression levels of α4β2 nAChRs and α7 nAChRs in the hippocampus and cortex (p < 0.05, p < 0.01). However, perinatal choline supplementation reversed the aforementioned fluoride‐induced changes. In short, these results demonstrated that choline alleviated perinatal fluoride‐induced learning and memory impairment, which will provide a rationale for the mitigation and prevention of fluoride‐induced brain damage.
Population shifts in some faeces and rumen bacteria profiles and subsequent blood LPS and lactate concentrations in lambs in the early period of subacute ruminal acidosis
Authors: Nikvand Ali Abbas , Nouri Mohammad , Gharibi Darioush , Rakhshandeh Rahman 
Published: October 2022

AbstractBackgroundIt is known that ruminal acidosis can induce harmal population shifts in some ruminal bacteria profiles. However, there is little information related to alterations in faecal and ruminal bacterial communities and relevant serum lipopolysaccharide (LPS) in sheep with subacute ruminal acidosis (SARA).ObjectivesThis study aimed to investigate alterations in the defined faecal and ruminal bacteria profiles and serum LPS and blood lactate concentrations in lambs with empirically induced SARA.MethodsFifteen lambs were served and undergone to induce SARA during a 7‐day period. Faecal and ruminal samples were taken to measure the pH and to perform the bacteriological works at 0 (just before induction), 8, 9, and 10 days of the challenge. Blood samples were collected to determine the serum LPS and lactate levels. The rumen and faecal samples were cultured to specify colony‐forming units (CFU) for Escherichia coli, Streptococcus Group D (SGD), and lactic acid bacteria (LAB).ResultsSerum LPS value had no significant increase in the affected lambs with SARA. Significant increasing trends were observed in faecal E. coli and LAB populations (p < 0.01). Rumen bacteriology revealed a rising trend for LAB and a falling trend for SGD populations (p < 0.01).Conclusion: Unlike cattle, LPS appears to be of minor importance in the pathogenesis of SARA in sheep. The increased ruminal and faecal LAB (4.00 × 107 CFU/ml or g) are proposed as valuable biomarkers for improving nutritional strategy and screening SARA in lambs.
Effects of decabromodiphenyl ethane flame retardant on the combustion behavior and physical‐mechanical properties of chloroprene rubber: Experimental and molecular dynamic simulation
Authors: Han Xiaokun , Li Jianxing , Lu Tianyun , Liu Ruiyin , Yan Zepei , Wang He 
Published: October 2022

AbstractHerein, a molecular dynamics simulation method was used to predict the compatibility of chloroprene rubber (CR) and decabromodiphenyl ethane (DBDPE) and to investigate the mechanical properties of CR‐based composites. The limiting oxygen index and cone calorimeter measurement values indicated that the addition of DBDPE was beneficial for reducing the peak heat release rate during combustion and facilitating the formation of compact and strong char layers for carbon black‐filled CR composites, resulting in efficient reduction of flammability and fire risk. Incorporation of DBDPE obviously delayed the dehydrochlorination of the CR matrix. Moreover, adding 50 phr DBDPE had little effect on the tensile strength and elongation at the break, and increased the modulus at 100% elongation by 64.3% in contrast to CR without DBDPE. However, the cold properties of CR vulcanizates decreased slightly with an increase in the DBDPE content.