bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative evaluation of Semaphorin-4D, Peptidylarginine deiminase-2 and Matrix metalloproteinase-8 levels of gingival crevicular fluid in periodontally healthy and Stage III periodontitis Smoker and non-smoker patients before and after Non-surgical periodontal therapy
Authors: Ikhar Aishwarya S , Kolte Rajashri A , Kolte Abhay P , Deshpande Neha M , Dahake Rahul N. 
Published: October 2022

Abstract

Background
The aim of the study was to evaluate Semaphorin-4D (SEMA-4D), Peptidylarginine deiminase-2 (PAD-2) and Matrix metalloproteinase-8 (MMP-8) levels of Gingival crevicular fluid (GCF) in periodontally healthy, stage III periodontitis smoker and non-smoker patients before and after Non-surgical periodontal therapy (NSPT).
Methods
60 patients, with an equal allotment ratio for 3 groups of periodontally healthy (Group I), Non-smokers and smokers with stage III periodontitis (Group II and Group III) were evaluated for clinical and biochemical parameters in GCF for levels of SEMA-4D, PAD-2 and MMP-8 through enzyme linked immunosorbent assay (ELISA). Patients were subjected to NSPT and the 3 months post therapy levels were examined.
Results
Group III exhibited higher values of PPD (8.06 ± 0.19 mm), CAL (8.94 ± 0.19 mm), PI (2.58 ± 0.19) while lower PBI (1.39 ± 0.19%) and GI (1.72 ± 0.19) scores as compared to Group II, which reduced significantly from baseline to 3 months in both the groups after NSPT. For SEMA-4D, PAD-2 and MMP-8 levels in GCF, minimum values were seen for Group I which increased incrementally to Group II and III. Also, the SEMA-4D, PAD-2 and MMP-8 levels in GCF significantly reduced from baseline to 3 months amongst Group II and III.
Conclusion
The results indicate increased GCF levels of SEMA-4D, PAD-2 and MMP-8 in Group II and III, thereby implying that these molecules play a crucial role in the pathogenesis of periodontal diseases.
Clinical Relevance:
SEMA-4D, PAD-2 and MMP-8 may be suitable biomarkers of the periodontal status in future.
Wear resistance and friction analysis of Ti6Al4V cylindrical ball-burnished specimens by vibration assistance
Authors: Velázquez-Corral Eric , Wagner Vincent , Jerez-Mesa Ramon , Delbé Karl , Lluma Jordi , Travieso-Rodriguez J.Antonio , Dessein Gilles 
Published: October 2022

Abstract
The objective of the research is to analyze the impact of the ultrasonic vibration assistance on the wear resistance due to the topology enhancement caused on Ti6Al4V cylindrical samples after surface modification through a ball burnishing process. The process parameters considered for this study are the burnishing force, the number of passes and the addition of a 40 kHz ultrasonic assistance, which are thought to enhance the surface topology and increase the hardener effect in terms of depth. A complete screening design of 3 factors was performed, revealing that the number of passes and the vibration assistance are the most important parameters for minimizing the wear volume loss, being 170 N of burnishing force, 3 passes and the addition of the vibration assistance as the best combination found. However, no significant difference in the friction force was observed. The topology results show that there is a decrease in the average roughness from 1.50 to 0.45 µm with optimal burnishing conditions. It was also analyzed the microstructure originated after the turning, the conventional ball burnishing and the vibration-assisted ball burnishing, being the last optimal in terms of depth affectation to the microstructure. Therefore, these results confirm an improvement in terms of wear enhancement, friction reduction and topology results when vibration assistance is added to a conventional ball burnishing process.
Dietary Pattern and Body Composition of Professional Football Players in Ghana: Implications on fitness and performance
Authors: Abdulai Kasim , Hayford Frank Ekow Atta , Axame Wisdom Kudzo , Alhassan Abdul Rauf , Brown Charles A. 
Published: October 2022

Abstract
Introduction

Good dietary practice is essential in sports as it improves the quality of training, maximizes performance and aids in the speedy recovery of players from injuries. A balanced diet provides adequate nutrients and energy to achieve these purposes. Nutritional status is also essential in ensuring optimum performance among athletes. But one may not achieve optimum nutritional status with poor dietary practices. Thus, footballers' poor dietary patterns and sub-optimal nutrition could lead to low fitness and poor performance during competitions.

Aim

This study aimed to assess the dietary pattern and body composition of professional football players in Ghana, and its implications on fitness and performance.

Methods

The study was cross-sectional. One hundred and nineteen footballers from five teams were randomly recruited for the study by quota sampling. Dietary behaviour pattern was assessed using a validated food frequency questionnaire, and body composition was measured using Omron bio-impedance body analyzer. Statistical analysis was performed using SPSS version 20 for windows and Microsoft Excel 2013. Correlations were determined among anthropometric variables, while eta-squared was used to determine associations between dietary patterns and anthropometric characteristics. Statistical significance was set at p < 0.05.

Results

The mean age of the footballers was 21.57 ± 4.3 years, with the majority (58%) within the 20–29-year group. Three dietary patterns explained 50% of the variation in diets of the footballers; 1) Fruits and vegetables, 2) energy and fiber foods (Modern Ghanaian), and 3) protein and starchy foods (Typical Ghanaian). Over 30% of the footballers were overweight. Animal protein consumption explained 9% [F (4, 130) = 2.446, p = 0.05] of the variation in BMI of the footballers with cereals and grains explaining 18% of the variation in BMI [F(4, 130) = 6.212, p < 0.001]. Percentage muscle mass negatively correlated to BMI (p < 0.01), whiles visceral fat correlated positively with BMI and body fat (p < 0.01).

Conclusion

Dietary pattern depicts low intakes of animal protein and fruits with high intakes of energy giving foods. Thus, professional footballers need targeted education on adequate diets to prevent the risk of iron deficiency which may result in low fitness and poor performance.
Lower prealbumin and higher CRP increased the risk of Voriconazole overexposure and adverse reactions
Authors: Lin Liangmo , Hong Mianhui , Wu Danna , Zhong Lili , Wang Min , Fu Xiangjun 
Published: October 2022

AbstractBackground Voriconazole(VRZ) is a commonly used antifungal drug showing significant individual differences and narrow therapeutic window.The aim of this study is to characterize the correlation between prealbumin(PA) or C-reactive protein (CRP) and Voriconazole(VRZ) overexposure and adverse reactions. Methods Patients received VRZ as prevention or treatment and performed therapeutic drug monitoring (TDM) were included. Biomarkers and combined medication were analyzed to find out factors that related to VRZ trough concentrations (Cmin) and overexposure (Cmin>5.0mg/L).ROC curves were used to determine the cut-off levels.Patients were divided into three groups according to different PA and CRP levels. Then incidence rate of VRZ adverse reactions between groups was analyzed. Results A total of 123 patients were included in the study. PA was negatively correlated,while CRP was positively correlated with VRZ concentrations.Lower PA or higher CRP was related to VRZ overexposure with the cut-off level of 145.5mg/L and 102.23mg/L respectively.Patients in group 2(PA < 145.5mg/L and CRP > 102.23mg/L) had a incidence rete of adverse reactions up to 70.27%,while incidence rate in group1(PA > 145.5mg/L and CRP < 102.23mg/L) and group 3(PA < 145.5mg/L and CRP < 102.23mg/L or PA > 145.5mg/L and CRP > 102.23mg/L) were 15.38% and 32.43%. Conclusions PA and CRP were both related to VRZ concentrations and overexposure. The risk of VRZ overexposure and adverse reactions significantly increased in patients with PA < 145.5mg/L and CRP > 102.23mg/L at the same time.
Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation
Authors: Todorova Vyara , Stauffacher Mia Fee , Ravotto Luca , Nötzli Sarah , Karademir Duygu , Ebner Lynn JA , Imsand Cornelia , Hauck Stefanie M , Samardzija Marijana , Saab Aiman S , Barros L Felipe , Weber Bruno , Grimm Christian 
Published: October 2022

Abstract
Background: Major retinal degenerative diseases, including age-related macular degeneration, diabetic retinopathy and retinal detachment, are associated with a local decrease in oxygen availability causing the formation of hypoxic areas affecting the photoreceptor (PR) cells. Here, we addressed the underlying pathological mechanisms of PR degeneration by focusing on energy metabolism during chronic activation of hypoxia-inducible factors (HIFs) in rod PR.
Methods: We used two-photon laser scanning microscopy (TPLSM) of genetically encoded biosensors delivered by adeno-associated viruses (AAV) to determine lactate and glucose dynamics in PR and inner retinal cells. Retinal layer-specific proteomics, in situ enzymatic assays and immunofluorescence studies were used to analyse mitochondrial metabolism in rod PRs during chronic HIF activation.
Results: PRs exhibited remarkably higher glycolytic flux through the hexokinases than neurons of the inner retina. Chronic HIF activation in rods did not cause overt change in glucose dynamics but an increase in lactate production nonetheless. Furthermore, dysregulation of the oxidative phosphorylation pathway (OXPHOS) and tricarboxylic acid (TCA) cycle in rods with an activated hypoxic response decelerated cellular anabolism causing shortening of rod photoreceptor outer segments (OS) before onset of cell degeneration. Interestingly, rods with deficient OXPHOS but an intact TCA cycle did not exhibit these early signs of anabolic dysregulation and showed a slower course of degeneration.
Conclusion: Together, these data indicate an exceeding high glycolytic flux in rods and highlight the importance of mitochondrial metabolism and especially of the TCA cycle for PR survival in conditions of increased HIF activity.
Prognostic CT features in patients with untreated thymic epithelial tumors
Authors: Dai Haiyang , Lan Bowen , Li Shengkai , Jiang Guihua , Tian Junzhang 
Published: October 2022

Abstract
Purpose
To determine the prognostic CT features in patients with untreated thymic epithelial tumors (TETs).
MATERIALS AND METHODS
The clinical data and CT imaging features of 194 patients with pathologically confirmed TETs were retrospectively reviewed. Subjects included 113 male and 81 female patients between 15 and 78 years of age, with a mean age of 53.8 years. The clinical outcomes were categorized according to whether relapse, metastasis or death occurred within 2 years since first diagnosed. The association between clinical outcomes and radiological features were determined using univariate and multivariate logistic regression analysis, while the survival status was analyzed by Cox regression.
RESULTS
There were 110 thymic carcinomas, 52 high-risk thymomas and 32 low-risk thymomas in this study. In the group of thymic carcinomas, 46 patients (41.8%) had tumor progress, local relapse or metastases and were categorized as poor outcomes. Vessel invasion and pericardium mass were confirmed of the independent predictors by logistic regression analysis (p < 0.01). In the group of high risk thymomas, 11 patients were categorized as poor outcomes and CT feature of pericardium mass was confirmed of the independent predictor (p < 0.01). In survivals analysis, Cox regression showed that features of lung invasion, great vessel invasion, lung metastases and distant organ metastasis were the independent predictors for overall survival in the group of thymic carcinomas(p < 0.01), while lung invasion and pericardium mass were the independent predictor for overall survival in the group of high-risk thymomas. No CT features were related with patient prognosis or survival in the group of low-risk thymomas.
CONCLUSION
CT could serve as an important tool in predicting the prognosis and survival in patients with TETs.
Ileorectal Intussusception Compared with End-to-end Ileorectal Anastomosis Following Laparoscopic Total Colectomy in Slow Transit Constipation：a Retrospective Cohort
Authors: Geng Hong Zhi , Xu Chen , Yu Yongjun , Cong Jiying , Zhang Zhao , Li Yuwei , Chen Qilong 
Published: October 2022

Abstract
Background Although end-to-end ileorectal anastomosis (EEIRA) followed total colectomy is the most effective surgical treatment for slow transit constipation (STC), but frequent diarrhea and urgent defecation have not been solved for more than 6 months after surgery. This study aimed to compare the defecating frequency, surgical complications, and quality of life after ileorectal intussusception anastomosis (IRIA) or EEIRA following laparoscopic total colectomy in STC.
Methods This is a prospectively collected and retrospectively analyzed the data of 100 consecutive STC patients treated by 1 medical team in Tianjin Union Medical Center from August 2016 to July 2021. There were 70 cases underwent IRIA and 30 cases underwent EEIRA. The incidence and mortality of postoperative complications, gastrointestinal quality of life score（GIQLI）and fecal incontinence quality of life score（FIQL）were followed up after operation at median 3 years. The frequency of defecation, use of antidiarrheal drugs, Wexner constipation score follow-up at 1 year.
Results A total of 100 patients(83 females and 17 males) were enrolled, and no death. Follow-up a year, there was more than 10 defecating frequency for 19 patients (19/30, 63,33%) in EEIRA group after operation. At 7 days, 1 month, 2 months, 3 months, 6 months after operation, and there were statistically significant difference in IRIA group for the reduction of defecation times compared with EEIRA (all P < 0.05); After 12 months of follow-up, there was no significant difference in the frequency of defecation between the two groups (P= 0.25); ANVOA analysis of variance showed that the number of defecation significantly decreased in IRIA group compared with EEIRA group F（5，490）= 193.09，(P = 0.00). Follow-up at median 3 years, there were prevalencesignificant difference in short-term and long-term complications between IRIA and EEIRA group, respectively (9/70, 12.86%) vs. (11/30, 36.67%)（P =0.03）, and (6/70, 8.57%) vs. (8/30, 26.67%)（P =0.01）. IRIA group were better than those of EEIRA group for FIQL and GIQLIscores follow-up at median 3 years, respectively (112.56 ± 8.25) vs. 105.14 ± 20.74)(P = 0.03), and (170.58 ± 8.24) vs. (164.00 ± 15.15)，(P = 0.01) .
Conclusion Follow-up at median 3 years, IRIA has a lower prevalence of surgical complications than EEIRA in the treatment of STC and significantly improve the quality of life, which can reduce the frequency of defecation within 1 year of follow-up.
Impact of migration on oral health outcomes of children in multiple-beneficial kindergartens in Nanning, southern China
Authors: Xu Nini , Deng Sicheng , Liang Yan , Chen Aihua , Zou Dan , Li Ling , Qiu Rongmin 
Published: October 2022

Abstract
Objective
To explore the effect of children’s migration on their oral health outcomes in multibeneficial kindergartens in Jiangnan District, Nanning, China, and to provide a basis for improving the oral health of migrant children.
Methods
A cross-sectional study was conducted among 470 children aged 5 years in Jiangnan District, Nanning, Guangxi. A questionnaire was used to collect information on their demographic and socioeconomic backgrounds, migration experience, eating habits, oral hygiene behaviours and utilization of dental care services. Dental caries of primary teeth was examined using the decayed, missing, and filled teeth (dmft) index recommended by the World Health Organization. Dental caries experience and oral health-related behaviours were compared between migrant and resident children. The impact of children’s migration attributes on their oral health outcomes was examined by univariate and multivariate analyses.
Results
Among the examined children, 52.3% were migrant children. The prevalence of caries among the children in multibeneficial kindergartens was 78.3%, and the mean number of dmft was 5.73 ± 5.00. The prevalence of caries was 81.7% for migrant children and 74.6% for resident children (p > 0.05). No significant difference was found in the mean numbers of DMFT between migrant children and resident children (5.96 ± 4.81 vs. 5.47 ± 5.20, p > 0.05). There were significant differences in the frequency of tooth brushing and parental help with tooth brushing, typical use of fluoride, regular dental check-ups and experience of dental fillings for caries between migrant and resident children (p < 0.05). The multivariate logistic regression analysis showed that among the children with caries, the proportion of resident children who had regular dental check-ups was 1.720 times higher than that of migrant children (95% CI = 1.155 ~ 2.560), and migrant children were more likely to have caries than resident children (OR = 3.313, 95% CI = 1.585 ~ 6.927).
Conclusion
Migration might be a significant predictive indicator for the poor utilization of dental care services by children in multibeneficial kindergartens in Nanning, China.
Mastering the Cahn–Hilliard equation and Camassa–Holm equation with cell-average based neural network method
Authors: Zhou Xiaofang , Qiu Changxin , Yan Wenjing , Li Biao 
Published: October 2022

Abstract
In this paper, we develop cell-average based neural network (CANN) method to approximate solutions of nonlinear Cahn–Hilliard equation and Camassa-Holm equation. The CANN method is motivated by the finite volume scheme and evolved from the integral or weak formulation of partial differential equations. The major idea of cell-average based neural network method is to explore a neural network to approximate the solution average difference or evolution between two neighboring time steps. Unlike traditional numerical methods, CANN method is not limited by the CFL restriction and can adapt large time steps for solution evolution, which is a significant advantage that classical numerical methods do not have. Once well trained, this method can be implemented as an fixed explicit finite volume scheme and applied to certain groups of initial value conditions for Cahn–Hilliard equation and Camassa-Holm equation without retraining the neural network. Furthermore, the CANN method also performs very well in handling data with corruption or low quality data generated by Gaussian white noise. Numerical examples are presented to demonstrate effectiveness, accuracy and capability of the proposed method.
WITHDRAWN: The prognostic value of the preoperative albumin/globulin and monocyte ratio in resected early-stage non-small cell lung cancer
Authors: Wu Wenqi , Wang Chen , Jiang Jingyuan , Zhang Zhe , Feng Chong , Zhao Yan , Lin Fengwu 
Published: October 2022

Abstract
Objective
This study investigated the prognostic value of the preoperative albumin/globulin to monocyte ratio (AGMR) in patients with resected non-small cell lung cancer (NSCLC).
Methods
The study retrospectively enrolled patients with resected NSCLC from the Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University from January 2016 to December 2017. Baseline demographic and clinicopathological data were collected. The preoperative AGMR was calculated. Propensity score matching (PSM) analysis was applied. The receiver operating characteristic curve was used to determine the optimal AGMR cut-off value. The Kaplan–Meier method was used to calculate the overall survival (OS) and disease-free survival (DFS). The Cox proportional hazards regression model was used to evaluate the prognostic value of the AGMR.
Results
A total of 305 NSCLC patients were included. The optimal AGMR value was 2.80. Before PSM. The high AGMR (> 2.80) group had a significantly longer OS (41.34 + 11.32 vs. 32.03 + 17.01 months; P < 0.01) and DFS (39.00 + 14.49 vs. 28.78 + 19.13 months; P < 0.01) compared with the low AGMR (≤ 2.80) group. Multivariate analyses showed that AGMR (P < 0.01) in addition to sex (P < 0.05), body mass index (P < 0.01), history of respiratory diseases (P < 0.01), lymph node metastasis (P < 0.01), and tumor size (P < 0.01) were associated with OS and DFS. After PSM, AGMR remained as an independent prognostic factor for OS (hazard ratio [HR] 2.572, 95% confidence interval [CI]: 1.470–4.502; P = 0.001) and DFS (HR 2.110, 95% CI: 1.228–3.626; P = 0.007).
Conclusion
The preoperative AGMR is a potential prognostic indicator for OS and DFS in resected early-stage NSCLC.
A diet rich in fermentable fiber promotes robust changes in the intestinal microbiota, mitigates intestinal permeability, and attenuates autoimmune uveitis
Authors: Nakamura Yukiko K. , Metea Christina , Llorenç Victor , Karstens Lisa , Balter Ariel , Lin Phoebe 
Published: October 2022

Abstract
Therapeutic approaches for noninfectious uveitis have expanded greatly over the past 10 years, but are limited by potential side effects and limited efficacy. Thus, therapeutic approaches that include less toxic, potentially preventative strategies to manage noninfectious uveitis are essential areas of study. Diets rich in fermentable fiber are potentially preventative in various conditions such as metabolic syndrome and type 1 diabetes. We studied the effects of various fermentable dietary fibers in an inducible model of experimental autoimmune uveitis (EAU) and found that they differentially modulated uveitis severity. A high pectin diet was the most protective, reducing clinical disease severity through the induction of regulatory T lymphocytes and the suppression of Th1 and Th17 lymphocytes at peak ocular inflammation in either intestinal or extra-intestinal lymphoid tissues. The high pectin diet also promoted intestinal homeostasis as shown by changes in intestinal morphology and gene expression, as well as intestinal permeability. Pectin-induced modulation of intestinal bacteria appeared to be associated with protective changes in immunophenotype in the intestinal tract, and correlated with reduced uveitis severity. In summary, our current findings support the potential for dietary intervention as a strategy to mitigate noninfectious uveitis severity.
Polyfluorinated Crosslinker-based Solid Polymer Electrolytes for Long-Cycling 4.5 V Lithium Metal Batteries
Authors: Tang Lingfei , Chen Bowen , Ma Chang-Qi , Zhang Zhonghan , Chen Junchao , zhang Fengrui , Dong Qingyu , Xue Guoyong , Chen Daiqian , Hu Chenji , Li Shuzhou , Liu Zheng , Shen Yanbin , Chen Qi , Chen Liwei 
Published: October 2022

Abstract
Solid polymer electrolytes (SPEs), which are favorable to form intimate interfacial contacts with electrodes, are promising electrolyte of choice for long-cycling lithium metal batteries (LMBs). However, typical SPEs with easily oxidized oxygen-bearing polar groups exhibit narrow electrochemical stability window (ESW), making it impractical to increase specific capacity and energy density of SPE based LMBs with charging cut-off voltage of 4.5 V or higher. Here, a polyfluorinated crosslinker has been applied to enhance oxidation resistance of SPEs via inductive electron-withdrawing effect of polyfluorinated segments transmitted through crosslinked networks. As a result, polyfluorinated crosslinked SPE exhibits a wide ESW, and the Li|SPE|LiNi0.5Co0.2Mn0.3O2 cell with a cutoff voltage of 4.5 V delivers a high discharge specific capacity of ~ 164.19 mAh g− 1 at 0.5 C and capacity retention of ~ 90% after 200 cycles. This work opens a new direction in developing SPEs for long-cycling high-voltage LMBs by using polyfluorinated crosslinking strategy.