bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between Attention Deficit Hyperactivity Disorder and epilepsy: a literature review
Authors: Ahmed Gellan K. , Darwish Alaa M. , Khalifa Hossam , Haridy Nourelhoda A. 
Published: May 2022

AbstractBackgroundAttention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurological disorder. ADHD has been linked to epilepsy.Main bodyADHD was found to be present in 30–40% of epileptic children. Researchers have developed numerous theories to explain how and why ADHD and epilepsy coexist. Whether ADHD and epilepsy symptoms are caused by co-occurring psychiatric disorders or by the temporary effects of epileptic discharges or by antiepileptic medicines is critical to consider. Diagnosis and treatment of individuals with ADHD and epilepsy are complicated and challenging from the clinical base.ConclusionsComorbidity between ADHD and epilepsy is still challenging to understand. The two diseases have a bidirectional link, so the association may not be coincidental. A disputable point is whether co-occurring ADHD and epilepsy symptoms represent a comorbid psychiatric disorder or are the epileptic discharges’ temporary effects, and are they related to antiepileptic drugs (AEDs). It is recommended to follow up with children with epilepsy or ADHD as they may develop comorbidity after a while.
Effect of caudal dexmedetomidine versus ketamine in prevention of emergence delirium in pediatric patients undergoing congenital inguinal hernia repair under sevoflurane anesthesia
Authors: Fahim Hany Magdy , Menshawi Mohammed Abdelsalam 
Published: May 2022

Abstract
Study objective
The aim of this study was to compare the effect of dexmedetomidine versus ketamine when added to caudal bupivacaine on the incidence of emergence delerium (ED), postoperative sedation, and analgesia in pediatric patients undergoing inguinal hernia repair under sevoflurane anesthesia.

Methods
Eighty seven pediatric patients who underwent elective inguinal hernia repair under sevoflurane anesthesia were randomly distributed into one of three equal groups. Group B (bupivacaine, n = 29), group BK (bupivacaine ketamine, n = 29), and group BD (bupivacaine dexmedetomidine, n = 29). Patients of group B received caudal injectate of 1 ml/kg bupivacaine 0.25%, while group BK patients received caudal injectate of 1 ml/kg bupivacaine 0.25% mixed with ketamine 0.5 mg/kg, and group BD patients received caudal injectate of 1 ml/kg bupivacaine 0.25% mixed with dexmedetomidine 1 μg/kg. Primary outcome measure was the assessment of the incidence of postoperative ED. Secondary outcomes included the postoperative sedation scores and postoperative Face, Legs, Activity, Cry, and Consolability (FLACC) pain scores, time to 1st postoperative analgesic, and total postoperative analgesic consumption. Also, the incidence of perioperative complications were assessed.

Results
The incidence of ED was significantly lower in group BD and BK compared with group B (P < 0.05) with no significant difference between group BD and BK (P > 0.05). Postoperative sedation scores were significantly higher in group BK and BD compared with group B (P < 0.05) at the 1st 30 min and 1st 2 h postoperative respectively; they were also significantly higher in group BD compared with group BK at (10 min–2 h) postoperative (P < 0.05). The duration of analgesia was significantly longer, and the total postoperative paracetamol consumption was significantly lower in group BD and BK compared with group B (P < 0.05); they were also significantly lower in group BD compared with group BK (P < 0.05). There was no intergroup significant difference as regards the incidence of perioperative complications.

Conclusions
Both dexmedetomidine (1 μg/kg) and ketamine (0.5 mg/kg) added to pediatric caudal block were effective to control pediatric ED after sevoflurane anesthesia. Patients received caudal dexmedetomidine had longer time to 1st postoperative analgesia and less postoperative analgesic consumption but longer postoperative sedation when compared with ketamine with no significant difference between both drugs as regards the incidence of perioperative adverse events.
Establishing multi-perspective instruments in early education during COVID-19: measuring the implementation of protective measures and the subjective level of information about pandemic-related regulations
Authors: Wieschke Johannes , Schacht Diana D. , Spensberger Florian , Klinkhammer Nicole , Grgic Mariana 
Published: May 2022

AbstractThis article describes the context, development, objectives, and content of three instruments. They stem from two questionnaires, used in the ERiK-Surveys 2020 and the Corona-KiTa-Study (CKS), two multi-perspective surveys which were developed by the German Youth Institute, to measure quality as well as challenges and solutions of the Corona pandemic in early childhood education and care (ECEC). The three instruments focus on (1) childcare center directors’ subjective level of information about pandemic-related regulations in the ERiK questionnaire and the extent of implementation of (2) hygiene and (3) protective measures in ECEC in the CKS questionnaire. First analyses suggest good performance and quality of the instruments. Further analyses (e.g., regarding validity and reliability) will be carried out. The instruments seem to be promising for future research, for example regarding medical questions in the field of ECEC.
Ethnotherapeutic practice of entomophagy species by the ethnic community of Tangkhul, Mao and Poumai community of Manipur, NER India
Authors: Devi W. D. , Bonysana Rk. , Kapesa K. , Mukherjee P. K. , Rajashekar Y. 
Published: May 2022

AbstractInsects are important bioresources as they supply numerous tangible and intangible benefits to humans. Day-to-day livings of many communities in the world are associated with insects as food, medicine, social beliefs, livelihood and other aspects. Many communities from immemorial time traditionally practice insects as food (entomophagy). People consumed insects for delicacy and nutritional purposes. However, some entomophagy species have medicinal value and many traditional healers used them for the treatment of various health ailments like sore throat, mouth ulcers, jaundice, body ache, wound healing, etc. In India, such traditions are widely practised in Northeast India more than other states of India. The focus of this research is on the traditional knowledge of entomophagy species having medicinal properties and social beliefs that are practised by the Tangkhul, Mao and Poumai ethnic community of Manipur, northeast region of India. Review literature was conducted through published journal paper, books and other electronic resources along with questioner’s survey. The present study recorded nine entomophagy species and four species having social beliefs according to the local people. This traditional knowledge is inherent from generation to generation, and to conserve such precious indigenous knowledge, proper documentation is necessary. The documented information on the ethnic therapeutic knowledge of the important entomo-therapeutics species of the local community can be transferred to modern pharmacology.
Morphometric analysis for prioritizing sub-watersheds of Murredu River basin, Telangana State, India, using a geographical information system
Authors: Shekar Padala Raja , Mathew Aneesh 
Published: May 2022

AbstractThe Murredu watershed in Telangana State was chosen for the morphometric and land use/land cover (LULC) analysis in this current study. Geographical information system (GIS) and remote sensing (RS) techniques can estimate the morphometric features and LULC analysis of a catchment. A total of fourteen sub-watersheds (SWs) were created from the watershed (SW 1 to SW 14), and sub-watersheds were prioritized based on morphometric and LULC features. Evaluation of various morphometric characteristics such as linear aspects, relief aspects, and aerial aspects has been carried out for every sub-watershed to prefer ranking. Four parameters were utilized for the LULC analysis to rank and prioritize sub-watersheds. The sub-watersheds were categorized into three groups as low, medium, and high, for soil and water conservation priority based on morphometric and LULC analysis. Using morphometric analysis, higher priorities have been assigned to SW 12 and SW 1, while using LULC analysis, higher priorities have been assigned to SW 9 and SW 11. SW 10 and SW 13 are the most common sub-watersheds that fall within the same priority while using morphometric and LULC analysis. The coefficient of regression results reveals that stream length and stream order, and also stream number and stream order, have a strong association. The deployment of soil and water conservation measures may be conducted in the high-priority sub-watersheds.
Exercise, Diet, and Weight Management During Cancer Treatment: ASCO Guideline
Authors: Ligibel Jennifer A. , Bohlke Kari , May Anne M. , Clinton Steven K. , Demark-Wahnefried Wendy , Gilchrist Susan C. , Irwin Melinda L. , Late Michele , Mansfield Sami , Marshall Timothy F. , Meyerhardt Jeffrey A. , Thomson Cynthia A. , Wood William A. , Alfano Catherine M. 
Published: May 2022

PURPOSETo provide guidance on exercise, diet, and weight management during active cancer treatment in adults.METHODSA systematic review of the literature identified systematic reviews and randomized controlled trials evaluating the impact of aerobic and resistance exercise, specific diets and foods, and intentional weight loss and avoidance of weight gain in adults during cancer treatment, on quality of life, treatment toxicity, and cancer control. PubMed and the Cochrane Library were searched from January 2000 to May 2021. ASCO convened an Expert Panel to review the evidence and formulate recommendations.RESULTSThe evidence base consisted of 52 systematic reviews (42 for exercise, nine for diet, and one for weight management), and an additional 23 randomized controlled trials. The most commonly studied types of cancer were breast, prostate, lung, and colorectal. Exercise during cancer treatment led to improvements in cardiorespiratory fitness, strength, fatigue, and other patient-reported outcomes. Preoperative exercise in patients with lung cancer led to a reduction in postoperative length of hospital stay and complications. Neutropenic diets did not decrease risk of infection during cancer treatment.RECOMMENDATIONSOncology providers should recommend regular aerobic and resistance exercise during active treatment with curative intent and may recommend preoperative exercise for patients undergoing surgery for lung cancer. Neutropenic diets are not recommended to prevent infection in patients with cancer during active treatment. Evidence for other dietary and weight loss interventions during cancer treatment was very limited. The guideline discusses special considerations, such as exercise in individuals with advanced cancer, and highlights the critical need for more research in this area, particularly regarding diet and weight loss interventions during cancer treatment. Additional information is available at www.asco.org/supportive-care-guidelines .
Financial Assistance Processes and Mechanisms in Rural and Nonrural Oncology Care Settings
Authors: Biddell Caitlin B. , Spees Lisa P. , Petermann Victoria , Rosenstein Donald L. , Manning Michelle , Gellin Mindy , Padilla Neda , Samuel-Ryals Cleo A. , Birken Sarah A. , Reeder-Hayes Katherine , Deal Allison M. , Cabarrus Kendrel , Bell Ronny A. , Strom Carla , DeAntonio Phyllis A. , Young Tiffany H. , King Sherry , Leutner Brian , Vestal Derek , Wheeler Stephanie B. 
Published: May 2022

PURPOSE: Patients with cancer are at heightened risk of experiencing financial hardship. Financial navigation (FN) is an evidence-based approach for identifying and addressing patient and caregiver financial needs. In preparation for the implementation of a multisite FN intervention, we describe existing processes (ie, events and actions) and mechanisms (ie, how events work together) connecting patients to financial assistance, comparing rural and nonrural practices. METHODS: We conducted in-depth, semistructured interviews with stakeholders (ie, administrators, providers, and staff) at each of the 10 oncology care sites across a single state (five rural and five nonrural practices). We developed process maps for each site and analyzed stakeholder perspectives using thematic analysis. After reporting findings back to stakeholders, we synthesized themes and process maps across rural and nonrural sites separately. RESULTS: Eighty-three stakeholders were interviewed. We identified six core elements of existing financial assistance processes across all sites: distress screening (including financial concerns), referrals, resource connection points, and pharmaceutical, insurance, and community/foundation resources. Processes differed by rurality; however, facilitators and barriers to identifying and addressing patient financial needs were consistent. Open communication between staff, providers, patients, and caregivers was a primary facilitator. Barriers included insufficient staff resources, challenges in routinely identifying needs, inadequate preparation of patients for anticipated medical costs, and limited tracking of resource availability and eligibility. CONCLUSION: This study identified a clear need for systematic implementation of oncology FN to equitably address patient and caregiver financial hardship. Results have informed our current efforts to implement a multisite FN intervention, which involves comprehensive financial toxicity screening and systematization of intake and referrals.
Runway Hospitality: Air Jamaica's “Rare Tropical Birds” and the Embodied Gender and Race Politics of Tourism, 1966–1980
Authors: Manley Elizabeth S. 
Published: May 2022

AbstractLaunched in 1966, Jamaica's national airline, Air Jamaica, exclusively employed women flight attendants, dubbed “rare tropical birds,” to embody and sell its elevated hospitality. Using Air Jamaica and its flight attendants as a lens on tourism across the region, this article demonstrates how, at midcentury, the industry was a complicated and contradictory mix of optimistic visions of advancement and problematic projections of creolized citizenship, all embedded in an imagery of a consumable Caribbean island paradise. The article interrogates the critical role that Air Jamaica's flight attendants and other women played in selling a harmonious Jamaicanness and idealized island fantasy to global North travelers, particularly in contrast to the larger national project of democratic socialist reform under Michael Manley. Despite efforts to put the tourism industry back into Jamaican hands, the act of trading on a romanticized racial hybridity and gendered, exoticized servility is inextricable from the story of tourism development in Jamaica and the region and points to the many contradictions entrenched (and persistent) in the industry.
An “Ordo-Thinker” on the Left: Jan Tinbergen on the National and International Economic Order
Authors: Dekker Erwin 
Published: May 2022

Abstract
Thinking in terms of order is believed to be a feature of several liberal economic schools, most famously the ordoliberal school. This article demonstrates that the work of Jan Tinbergen provides a good example of “thinking in orders” on the left. His analysis of the national and international economic system is conducted in terms of order, and he believed that economic stability was primarily the result of the institutional order of an economy. This article shows that these ideas were shaped in discussions over the Plan of Labor (comparable to the New Deal) in the Netherlands as well as during his period in Geneva at the League of Nations. Crucial in Tinbergen's work on order is the optimal set of institutions, a so-called optimal order, that specifies the right level of centralization and decentralization in economic decision making. This focus on order is an important move away from the equilibrium-focused work on econometric studies of the business cycle theories of the 1930s. By showing the importance of the discussions in Geneva for Tinbergen's work, the article also problematizes Slobodian's recent argument that the Geneva school was neoliberal in nature. Instead, we demonstrate that it is better understood as internationalist and bipartisan.
Differences in All-Cause Mortality Among Transgender and Non-Transgender People Enrolled in Private Insurance
Authors: Hughes Landon D. , King Wesley M. , Gamarel Kristi E. , Geronimus Arline T. , Panagiotou Orestis A. , Hughto Jaclyn M.W. 
Published: May 2022

Abstract
Few studies have analyzed mortality rates among transgender (trans) populations in the United States and compared them to the rates of non-trans populations. Using private insurance data from 2011 to 2019, we estimated age-specific all-cause mortality rates among a subset of trans people enrolled in private insurance and compared them to a 10% randomly selected non-trans cohort. Overall, we found that trans people were nearly twice as likely to die over the period as their non-trans counterparts. When stratifying by gender, we found key disparities within trans populations, with people on the trans feminine to nonbinary spectrum being at the greatest risk of mortality compared to non-trans males and females. While we found that people on the trans masculine to nonbinary spectrum were at a similar risk of overall mortality compared to non-trans females, their overall mortality rate was statistically smaller than that of non-trans males. These findings provide evidence that some trans and non-trans populations experience substantially different mortality conditions across the life course and necessitate further study.
Digital Archives and the Literature Classroom
Authors: Mattison Laci , Tait-Ripperdan Rachel 
Published: May 2022

AbstractThis article describes the implementation of and assessment findings for a digital archival assignment in the 3000-level Victorian Literature and Culture course at Florida Gulf Coast University. The assignment utilized ProQuest's database, Queen Victoria's Journals, which comprises the extant journals of Queen Victoria, and demonstrated the value of primary historical research and digital archives in enhancing student content knowledge, information literacy, and critical thinking.
Transcriptomic Profiling Revealed Lnc-GOLGA6A-1 as a Novel Prognostic Biomarker of Meningioma Recurrence
Authors: Slavik Hanus , Balik Vladimir , Kokas Filip Zavadil , Slavkovsky Rastislav , Vrbkova Jana , Rehulkova Alona , Lausova Tereza , Ehrmann Jiri , Gurska Sona , Uberall Ivo , Hajduch Marian , Srovnal Josef 
Published: May 2022

BACKGROUND:
Meningioma is the most common primary central nervous system neoplasm, accounting for about a third of all brain tumors. Because their growth rates and prognosis cannot be accurately estimated, biomarkers that enable prediction of their biological behavior would be clinically beneficial.

OBJECTIVE:
To identify coding and noncoding RNAs crucial in meningioma prognostication and pathogenesis.

METHODS:
Total RNA was purified from formalin-fixed and paraffin-embedded tumor samples of 64 patients with meningioma with distinct clinical characteristics (16 recurrent, 30 nonrecurrent with follow-up of >5 years, and 18 with follow-up of <5 years without recurrence). Transcriptomic sequencing was performed using the HiSeq 2500 platform (Illumina), and biological and functional differences between meningiomas of different types were evaluated by analyzing differentially expression of messenger RNA (mRNA) and long noncoding RNA (IncRNA). The prognostic value of 11 differentially expressed RNAs was then validated in an independent cohort of 90 patients using reverse transcription quantitative (real-time) polymerase chain reaction.

RESULTS:
In total, 69 mRNAs and 108 lncRNAs exhibited significant differential expression between recurrent and nonrecurrent meningiomas. Differential expression was also observed with respect to sex (12 mRNAs and 59 lncRNAs), World Health Organization grade (58 mRNAs and 98 lncRNAs), and tumor histogenesis (79 mRNAs and 76 lncRNAs). Lnc-GOLGA6A-1, ISLR2, and AMH showed high prognostic power for predicting meningioma recurrence, while lnc-GOLGA6A-1 was the most significant factor for recurrence risk estimation (1/hazard ratio = 1.31; P = .002).

CONCLUSION:
Transcriptomic sequencing revealed specific gene expression signatures of various clinical subtypes of meningioma. Expression of the lnc-GOLGA61-1 transcript was found to be the most reliable predictor of meningioma recurrence.
The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development
Authors: Wang Yanshu , Venkatesh Arjun , Xu Jiajia , Xu Mingxin , Williams John , Smallwood Philip M. , James Aaron , Nathans Jeremy 
Published: May 2022

ABSTRACT
In central nervous system vascular endothelial cells, signaling via the partially redundant ligands WNT7A and WNT7B requires two co-activator proteins, GPR124 and RECK. WNT7A and RECK have been shown previously to play a role in limb development, but the mechanism of RECK action in this context is unknown. The roles of WNT7B and GPR124 in limb development have not been investigated. Using combinations of conventional and/or conditional loss-of-function alleles for mouse Wnt7a, Wnt7b, Gpr124 and Reck, including a Reck allele that codes for a protein that is specifically defective in WNT7A/WNT7B signaling, we show that reductions in ligand and/or co-activator function synergize to cause reduced and dysmorphic limb bone growth. Two additional limb phenotypes – loss of distal Lmx1b expression and ectopic growth of nail-like structures – occur with reduced Wnt7a/Wnt7b gene copy number and, respectively, with Reck mutations and with combined Reck and Gpr124 mutations. A third limb phenotype – bleeding into a digit – occurs with the most severe combinations of Wnt7a/Wnt7b, Reck and Gpr124 mutations. These data imply that the WNT7A/WNT7B-FRIZZLED-LRP5/LRP6-GPR124-RECK signaling system functions as an integral unit in limb development.
MRI as a biomarker for breast cancer diagnosis and prognosis
Authors: Galati Francesca , Rizzo Veronica , Trimboli Rubina Manuela , Kripa Endi , Maroncelli Roberto , Pediconi Federica 
Published: May 2022

Abstract
Breast cancer (BC) is the most frequently diagnosed female invasive cancer in Western countries and the leading cause of cancer-related death worldwide. Nowadays, tumor heterogeneity is a well-known characteristic of BC, since it includes several nosological entities characterized by diﬀerent morphologic features, clinical course and response to treatment. Thus, with the spread of molecular biology technologies and the growing knowledge of the biological processes underlying the development of BC, the importance of imaging biomarkers as non-invasive information about tissue hallmarks has progressively grown. To date, breast magnetic resonance imaging (MRI) is considered indispensable in breast imaging practice, with widely recognized indications such as BC screening in females at increased risk, locoregional staging and neoadjuvant therapy (NAT) monitoring. Moreover, breast MRI is increasingly used to assess not only the morphologic features of the pathological process but also to characterize individual phenotypes for targeted therapies, building on developments in genomics and molecular biology features. The aim of this review is to explore the role of breast multiparametric MRI in providing imaging biomarkers, leading to an improved differentiation of benign and malignant breast lesions and to a customized management of BC patients in monitoring and predicting response to treatment. Finally, we discuss how breast MRI biomarkers offer one of the most fertile ground for artificial intelligence (AI) applications. In the era of personalized medicine, with the development of omics-technologies, machine learning and big data, the role of imaging biomarkers is embracing new opportunities for BC diagnosis and treatment.