bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers and facilitators of maternal health care services use among pastoralist women in Ethiopia: Systems thinking perspective
Authors: Jebena Mulusew G. , Tesfaye Million , Abashula Gudina , Balina Sena , Jackson Ruth , Assefa Yibeltal , Kifle Yibeltal , Tesfaye Chala , Yilma Melaku , Hiruy Abiy , Teklu Alula , Bahru Bezawit Adugna , Assefa Esubalew , Demissie Mekdes , Mitike Getnet , Tushune Kora 
Published: June 2022

AbstractWe explored the barriers and facilitators of maternal health care service use among women in the pastoralist region of Ethiopia.We used a mixed methods design—focus group discussions, key informant interviews, review of the literature and Participatory Ethnographic Evaluation Research (PEER) methods followed by a household survey among randomly chosen pastoralist women of reproductive age (n = 1,499). We used multi-variable regression analyses, and a p value ≤ 0.05 was set to determine statistical significance. In addition, we analysed qualitative data thematically and developed a causal loop diagram using dynamic synthesis methodology to analyse non-linearity, intricate relationships of the variable of interests.In this study, 20.6% of women used modern contraceptive methods, 44.6% had four or more antenatal visits and 38.4% of sampled women received skilled delivery services. We observed multiple individual and community related factors such as education, income and women’s and their partner’s knowledge, perceptions, husband approval, social norms and value-expectations and providers’ gender preferences and health systems factors such as access to health facilities, place of living, provider's cultural competency skills, supplies, delivery positions, economic and political stability, and provider's attitude were linked to maternal health care services utilization among women in pastoralist regions.Approaches towards pastoralists’ health care delivery systems should be responsive to their cultural and political ecology and human agency.
A comprehensive review of Hungarian futures studies in light of international journal articles
Authors: Nováky Erzsébet , Kristóf Tamás 
Published: June 2022

AbstractThis article offers an overview of the evolution of Hungarian futures studies via a systematic literature review of articles with at least one Hungarian futurist (co-)author, published in high-ranking international or English-language Hungarian journals. The review reveals how researchers from a relatively small European country, where central planning had been applied for decades, have made their way to the pages of prestigious international journals and disseminated their results in a diverse range of articles to the global research community. The number of these publications has increased decade by decade. Results of statistical-based literature review demonstrate that research period and research topic are in strong association with the quality of journal articles, yet scientometric features of Hungarian futurist (co-)authors are not significant in this aspect. However, spectacular clustering of articles can be accomplished based on the citation statistics of Hungarian futurist (co-)authors.
The mismatch between morphological and molecular attribution of three Glossogobius species in the Mekong Delta
Authors: Truong Ngon T. , Phan Gieo H. , Lam Tran T. H. , Nguyen Ton H. D. , Khang Do T. , Tran Men T. , Tran Nam S. , Dinh Quang M. 
Published: June 2022

AbstractBackgroundThe Vietnamese Mekong Delta (VMD) is the granary for the whole country, providing animal and plant resources, especially fish. Among the fish species, the genusGlossogobiusare the majority. Until now, research for this species has been solely relied on fish morphology for identification. Hence, the present study aimed to describe the morphological variations of the morphologically identified gobies and to validate them at the molecular level through the sequencing of the barcode region, the mitochondrial cytochrome C oxidase subunit I (COI) gene to preliminary provide fundamental information for conservation.ResultsThe mitochondrial cytochrome C oxidase subunit I genes were amplified successfully with an approximate size of 650-680 bp. Their morphometries were quite different, and the genetic distance (p-value) among groups and within groups ranged from 0.00 to 0.12. The similarity of the COI gene sequences between the analyzed samples and in the NCBI database was from 87.01 to 100%. The specimens ofG. aureus,G. giurisandG. sparsipapilluswere interspersed in small branches of the phylogenetic tree with a low genetic distance highlighting that the genetic diversity of COI gene was low among species. Therefore, it is recommended that a combination of morphological method and mtCOI DNA barcoding is required for accurate classification.ConclusionThis study helps determine three distinct lineages ofGlossogobiusspecies, so an appropriate strategy can be proposed for exploitation and conservation.
Retinal vascular occlusion in patients with the Covid-19 virus
Authors: Shiroma Helio F. , Lima Luiz H. , Shiroma Yuri B. , Kanadani Tereza C. , Nobrega Mario J. , Andrade Gabriel , de Moraes Filho Milton Nunes , Penha Fernando M. 
Published: June 2022

Abstract
Background
The coronavirus disease (COVID-19) can cause acute respiratory distress syndrome with dyspnea, anosmia, fever, and cough. Few studies describing ocular findings have been reported. The current case series, reports the clinical findings and natural history of patients with retinal vascular occlusion after COVID-19 infection.

Case presentations
Patients from multiple Brazilian hospitals who had clinical and laboratory diagnoses of COVID-19 with retinal vein or arterial occlusion were analyzed retrospectively. The baseline demographics, clinical presentations of COVID-19, comorbidities, risk factors for thromboembolic events, and use of anticoagulant drugs were reviewed. The relevant clinical findings associated with the retinal vascular occlusive event, management, and outcomes were reported. Fourteen cases of retinal vascular occlusion within 3 months of the laboratory confirmed COVID-19 infection were identified. Three of which required hospitalization for COVID-19 management. Eight cases had central retinal vein occlusion, three branch retinal vein occlusion, one hemispheric retinal vein occlusion, and two central arterial occlusion. The mean patient age at presentation was 48 years; the visual acuity ranged from light perception to 20/20. Nine patients received intravitreal injections of anti-angiogenic drugs and one received ketorolac tromethamine drops for the management of secondary macular edema; four were untreated.

Conclusions
COVID-19 patients may rarely have ocular manifestations of the disease. It was presented a case series of vascular occlusion events that may be related to COVID-19 infection, since these thrombotic events are actively involved in the disease pathophysiology. These cases emphasize the need for further investigation of ocular complications associated with this disease.
Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas
Authors: Rodon Jordi , Mykytyn Anna Z. , Cantero Guillermo , Albulescu Irina C. , Bosch Berend-Jan , Brix Alexander , Audonnet Jean-Christophe , Bensaid Albert , Vergara-Alert Júlia , Haagmans Bart L. , Segalés Joaquim 
Published: June 2022

AbstractOngoing outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) continue posing a global health threat. Vaccination of livestock reservoir species is a recommended strategy to prevent spread of MERS-CoV among animals and potential spillover to humans. Using a direct-contact llama challenge model that mimics naturally occurring viral transmission, we tested the efficacy of a multimeric receptor binding domain (RBD) particle-display based vaccine candidate. While MERS-CoV was transmitted to naïve animals exposed to virus-inoculated llamas, immunization induced robust virus-neutralizing antibody responses and prevented transmission in 1/3 vaccinated, in-contact animals. Our exploratory study supports further improvement of the RBD-based vaccine to prevent zoonotic spillover of MERS-CoV.
A rare case of hepatic ectopic pregnancy
Authors: Katiyar Glory , Fernandes Yasmin , Lawande Shikha , Kumar Pawan , Vernekar Jeevan A. 
Published: June 2022

Abstract
Background
Hepatic pregnancy is an uncommon ectopic site of gestational sac implantation. Clinical signs and symptoms simulate digestive or hepatobiliary diseases, making this a less common clinical diagnosis. Delay in diagnosis increases the risk of rupture and life threatening torrential hemorrhage. Detailed abdomino-pelvic ultrasound confirms the diagnosis, and MRI along with CT angiography guides the management.

Case presentation
We report a case of a 25-year-old multiparous female who presented with right hypochondrial and lumbar pain. Ultrasound demonstrated live ectopic gestational sac attached to the inferior surface of segment VI of liver with perigestational hematoma and patient underwent successful surgical excision with segmental resection of liver.

Conclusions
Primary hepatic ectopic pregnancy is a very rare entity. Importance resides in maintaining a high level of suspicion along with timely radiological investigations for successful clinical outcome.
RAD51B Harbors Germline Mutations Associated With Pancreatic Ductal Adenocarcinoma
Authors: Xie Fanfan , Ding Ding , Lin Cong , Cunningham Dea , Wright Michael , Javed Ammar A. , Azad Nilo , Lee Valerie , Donehower Ross , De Jesus-Acosta Ana , Le Dung T. , Pishvaian Michael , Shin Eun Ji , Lennon Anne Marie , Khashab Mouen , Singh Vikesh , Klein Alison P. , Roberts Nicholas J. , Hacker-Prietz Amy , McPhaul Thomas , Burkhart Richard A. , Burns William R. , Narang Amol , Zaheer Atif , Fishman Elliot K. , Thompson Elizabeth D. , Anders Robert , Yu Jun , He Jin , Wolfgang Christopher L. , Zheng Lei , Liu Dongbing , Wu Kui , Laheru Daniel A. 
Published: June 2022

PURPOSE Genetic alterations in many components of the homologous recombination, DNA damage response, and repair (HR-DDR) pathway are involved in the hereditary cancer syndromes, including familial pancreatic cancer. HR-DDR genes beyond BRCA1, BRCA2, ATM, and PALB2 may also mutate and confer the HR-DDR deficiency in pancreatic ductal adenocarcinoma (PDAC). METHODS We conducted a study to examine the genetic alterations using a companion diagnostic 15-gene HR-DDR panel in PDACs. HR-DDR gene mutations were identified and characterized by whole-exome sequencing and whole-genome sequencing. Different HR-DDR gene mutations are associated with variable homologous recombination deficiency (HRD) scores. RESULTS Eight of 50 PDACs with at least one HR-DDR gene mutation were identified. One tumor with BRCA2 mutations is associated with a high HRD score. However, another tumor with a CHEK2 mutation is associated with a zero HRD score. Notably, four of eight PDACs in this study harbor a RAD51B gene mutation. All four RAD51B gene mutations were germline mutations. However, currently, RAD51B is not the gene panel for germline tests. CONCLUSION The finding in this study thus supports including RAD51B in the germline test of HR-DDR pathway genes.
Diabetic Retinopathy May Be a Predictor of Stroke in Patients With Diabetes Mellitus
Authors: Wang Zicheng , Cao Dan , Zhuang Xuenan , Yao Jie , Chen Ruoyu , Chen Yesheng , Zheng Kangyan , Lu Peiyao , Zhang Liang 
Published: June 2022

Abstract

Background
It is unclear whether diabetic retinopathy (DR) can be a predictor of stroke. In this research context, the objective of our study was to investigate whether there is a significant association between DR and stroke in diabetic patients by meta-analysis.

Methods
After a systematic search of studies in electronic databases, we screened all studies reporting the risk of DR status and stroke incidence and calculated their odds ratios (ORs) and hazard ratios (HRs). The effects of type of diabetes and severity of DR were also considered for subgroup analysis.

Results
We included 19 studies involving 45 495 patients. A pooled HR = 1.62 (1.28-2.06) were found for the risk of DR and stroke in diabetic patients. In a subgroup analysis performed on the type of diabetes, the results showed a significant association between stroke incidence and DR status in patients with type 2 diabetes (T2D) (OR: 1.78; 95% CI, 1.53-2.08), but this association was not conclusive in type 1 diabetes (T1D) (OR: 1.77; 95% CI, 0.48-6.61). The results of the subgroup analysis with diabetes severity showed that both mild and moderate nonproliferative diabetic retinopathy (NPDR) status and severe NPDR and worse status significantly increased the risk of stroke with HRs of 2.01 (1.45-2.78) and 2.27 (1.52-3.39), respectively.

Conclusion
DR status in diabetic patients is associated with an increased risk of stroke. This correlation was robust in patients with T2D, but uncertain in T1D. Based on this result, we have perhaps found the new factor for stroke management, so we analyzed the necessity and advantages of considering DR as a factor for stroke screening and risk management in our studies.
Economia e/ou saúde: uma análise pragmática do posicionamento do governo Bolsonaro no ambiente digital durante a pandemia
Authors: Figueira Mayra Duarte , Neves-Hora Lídia Gurgel , Hora Daniel 
Published: June 2022

Em consonância com as práticas sociais não virtuais, as interações nos ambientes digitais podem consolidar discursos que refletem solidariedade, justiça social e dignidade humana, mas também o contrário disso, como reforço à desigualdade social, e construção de ódio e desinformação. Este artigo propõe uma análise, sob a perspectiva pragmática, de uma publicação do presidente da República brasileiro, Jair Messias Bolsonaro, na rede social Facebook, em 8 de julho de 2020, um dia após o anúncio de seu teste positivo para covid-19, e dos comentários realizados na postagem. Para isso, baseamo-nos na elaboração dos enquadres e footing (GOFFMAN ([1979] 2002), bem como nas representações socialmente construídas pela quebra das máximas conversacionais, propostas por Grice (1982). Apoiamo-nos nas ferramentas da ciência de dados e na Análise do Discurso Digital (PAVEAU, 2014, 2017) para analisar a linguagem em seu ambiente/contexto nativo on-line, inclusive com as informações do algoritmo.Constatamos, pois, que os enquadres de Jair Bolsonaro revelam uma produção discursiva que prioriza aspectos não sociais e legitimam um desprezo pelos cuidados sanitários durante o período da pandemia e essa circulação e da ocupação discursiva no ambiente digital é corroborada pelos interlocutores na postagem em análise.
O debate sobre aporofobia promovido pelo Padre Júlio Lancellotti nas redes sociais: uma análise semiolinguística
Authors: Melo Mônica Souza 
Published: June 2022

Nosso artigo tem como objetivo descrever e analisar a repercussão das publicações do padre Júlio Lancelotti no instagram, ao longo do mês de janeiro de 2022 que denunciavam a prática da aporofobia pela adoção de uma “arquitetura hostil” em várias cidades brasileiras. Interessam-nos, especificamente, os comentários que se opõem às publicações de Lancelotti e que reproduzem e reforçam o sentimento de aversão ao pobre que o padre denuncia. Para empreender nossa análise, adotamos como eixo teórico a análise semiolinguística do discurso, de Patrick Charaudeau, em especial a noção de imaginário sociodiscursivo e os procedimentos relativos ao modo de organização argumentativo, definidos por esse autor. Tal análise nos permitiu constatar que as publicações que apoiam as atitudes de aporofobia citam argumentos que reforçam uma série de imaginários negativos associados à imagem da pessoa em situação de rua, que a colocam como um ser nocivo à população em geral, o que faz com que essas publicações tenham o potencial de incitar os leitores a fomentarem um sentimento de aversão ao pobre.
Button batteries in the ear, nose and throat: a novel survey of knowledge of UK advanced nurse practitioners
Authors: Lotfallah Andrew , Al-Hity Shams , Rodrigues Rodney , Hamzah Aisha , Kumar Ravi , Darr Adnan 
Published: June 2022

Background: Button battery (BB) impaction in the ear, nose and throat can result in significant morbidity. Advanced nurse practitioners (ANPs) are increasingly responsible for initial patient assessment and prompt escalation to otolaryngologists for definitive management. Aim: Our novel national study aimed to assess ANPs' knowledge with respect to the assessment and management of patients with BBs in the ear, nose and throat. Method: A national 13-point survey was disseminated among ANPs over a 2-week period. Knowledge was assessed through eight multiple choice questions with a maximum attainable score of 21. Findings: A total of 242 responses were analysed. Knowledge deficits were identified in all domains (mean overall score 8.5/21), including presenting clinical features, preliminary investigations and intervention strategies. The overwhelming majority of respondents (97%; n=234) advocated for further training. Conclusion: A need for further education has been highlighted by this surveyed cohort of ANPs. Implementation of standardised protocols, virtual resources and simulation platforms may address knowledge deficits.
Case study: night compression use in a patient with Milroy's disease
Authors: Chohan Ambreen , Sumner Simon , Olivier Mairi , Whitaker Justine 
Published: June 2022

Aim: Lymphoedema is associated with dysfunctional lymphatics, tissue fibrosis and inflammatory changes in the skin and local tissue. Ensuring compression supports tissue health is crucial to managing lymphoedema. Providing patients with safe compression which enhances their tissue health is paramount when supporting their 24-hour self-management regimens. This case study explores the use of a new compression garment in two sitting positions in an adult with primary lymphoedema. Method: An 18-year-old female (body mass index 25.2 kg/m2) with Milroy's disease was recruited. She attended two separate 1-hour sessions to evaluate tissue oxygenation (StO2) in chair-sitting and long-sitting (sitting up with a supported back and legs horizontal) positions. Following removal of her usual class 2 (20–30 mmHg) flat-knit compression hosiery, StO2 was recorded for 20 minutes: pre-, during and post the application of an adjustable compression garment (Lohmann & Rauscher) to the right leg. Results: In the long-sitting position, StO2 levels started high at baseline (94.5%), and were relatively maintained both during and post-a short 20-minute intervention (94.1%). In the chair-sitting position, StO2 levels were significantly lower at baseline (52%), showing a 77% increase during the intervention (92%), followed by a small 9% decrease post-intervention (83.7%). Conclusion: This compression garment significantly increased StO2 levels in the chair-sitting position, while maintaining the effects of the patient's compression stockings, in the long-sitting position. Similar to non-lymphoedematous limbs, the patient's normal prescription hosiery maintains StO2. Through implementation of the short intervention sessions, night compression garments may have the potential to improve tissue health in individuals with primary lymphoedema, encouraging self-management and offering a potential night compression solution where the need arises in a 24-hour management plan.
Changes in the development of opioid tolerance on re-exposure among people who use heroin: A qualitative study
Authors: Kesten Joanna May , Holder Ed , Ayres Rachel , Ellis Pete , Taylor Steve , Hickman Matthew , Henderson Graeme 
Published: June 2022

Background and aims
This qualitative study aimed to explore how the development of tolerance to both the psychoactive and respiratory depressant effects of heroin on re-exposure are experienced by people who use heroin.

Methods
Semi-structured one-to-one interviews were conducted with 20 adults who currently or previously used heroin (for at least 6 months), with any type of administration (injected, smoked) and experience of abstinence (at least 2 weeks) and relapse. Topic guides explored the participants understanding of tolerance, their experience of developing tolerance to heroin and of tolerance following relapse. Interviews were audio‐recorded and transcribed. Thematic analysis was used to generate salient themes.

Results
The analysis produced three broad themes: lay understanding of tolerance; tolerating tolerance; and rapid tolerance development following relapse. Tolerance was defined as the body adapting to regular drug use, so that the drug no longer produced the same level of effect. Tolerance was experienced as interacting and co-developing with physical dependence and the symptoms of withdrawal. Indeed, several participants did not differentiate between tolerance and dependence. Most participants did not notice tolerance to respiratory depression. Tolerance levels fluctuated—increasing over periods of regular use and reducing when abstinent. Using more drug was the most common response to increasing tolerance to the desired effects. On re-use following abstinence, tolerance was experienced as developing more quickly in the most recent relapse compared to the first. Tolerance was also perceived to return more quickly with each abstinence-relapse cycle.

Conclusions
Qualitative accounts of tolerance report that tolerance returns more quickly with each relapse episode. By elucidating the mechanism(s) involved and potentially discovering how they could be switched on prior to relapse occurring we might be able to develop a beneficial harm reduction treatment for people in abstinence that would protect against overdose occurring on subsequent relapse.
Is latent Toxoplasma gondii infection associated with the occurrence of schizophrenia? A case-control study
Authors: Ademe Muluneh , Kebede Tadesse , Teferra Solomon , Alemayehu Melkam , Girma Friehiwot , Abebe Tamrat 
Published: June 2022

Introduction
Neurotropic pathogens such as Toxoplasma gondii (T. gondii) which result in chronic infections in the brain are associated with mental illnesses. In view of this, a growing body of literature has revealed the possible interaction of schizophrenia and T. gondii infection.

Method
A case-control study was conducted from February 2018 to January 2019 among 47 Schizophrenia patients and 47 age and sex-matched controls. Data was collected using a structured questionnaire. Serum was used for serological analysis of anti-T. gondii IgG and IgM antibodies through chemiluminescent immunoassay. Proportions and mean with standard deviations (SD) were used as descriptive measures and variables with p-values <0.05 were considered as statistically significant and independently associated with schizophrenia.

Result
The mean ages of schizophrenia patients and controls were 29.64 ± 5.8 yrs and 30.98 ± 7.3 yrs, respectively. We found that 81.9% (77/94) of the study subjects had a positive anti-T. gondii IgG antibody. While the difference is statistically insignificant, schizophrenic patients have a marginally higher seroprevalence of toxoplasmosis than controls (87.2% vs 80.9%; p = 0.398). Schizophrenia cases who live in homes with soil floors have a significantly higher T. gondii infection as compared to those who live in homes with cement/ceramic floors (90.9% vs 33.3%; p = 0.004). Furthermore, there was a significantly lower T. gondii infection among schizophrenic cases who were taking antipsychotic medication for more than three yrs (79.3% vs 100.0%, p = 0.039). On the other hand, among all study subjects who have T. gondii infection, subjects who are addicted to khat and alcohol were about seven times more likely to develop schizophrenia (71.4% vs 47.7%, OR = 7.13, p = 0.024).

Conclusion
Our data is not sufficient to show a significant positive correlation between T. gondii infection and schizophrenia. For study subjects with T. gondii infection, addiction to khat and alcohol is one of the risk factors for schizophrenia.