bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantum Design for Advanced Qubits
Authors: Lu Chao-Yang , Liu Feng-Ming , Chen Mingcheng , Wang Can , Li Shaowei , Shang Zhong-Xia , Ying Chong , Wang Jian-Wen , Peng Cheng-Zhi , Zhu Xiaobo , Pan Jian-Wei 
Published: February 2022

Abstract
The past half century has witnessed the rapid development of integrated circuits from several to billions of electronic components, where a crucial enabling method was the electronic computer-aided design. Similarly, simulations of the quantum electrocircuits will play a key role in designing advanced quantum computers. While these simulations could be done classically on a small scale, the resources required for the classical simulations will grow exponentially with the complexity of the strongly-correlated quantum hardwares. Here, we demonstrate quantum computer-aided design of a new high-performance superconducting qubit based on variational quantum simulations. The discovered new qubits intrinsically have important features superior to the widely used transmons qubits, because the new design eliminates the charge noise but without sacrificing anharmonicity and thus has a larger anharmonicity than the transmons. The new qubit - which we call “plasmonium” - is compatible with the control technologies in the transmon, exhibits long coherence time, and can bring in a number of practical advantages, including shrinking physical sizes, improving gate and readout fidelity, reducing state leakage, and alleviating frequency crowding in multi-qubit devices.
Application of the Plan-Do-Check-Act cycle for managing immune-related adverse events
Authors: Hibi Satoshi , Shirokawa Yuko , Nanya Kengo , Kato Yuko , Ito Nobuto , Kataoka Takae , Yoshida Takashi , Marumo Yoshiaki , Kayukawa Satoshi , Yuasa Shu , Ina Kenji 
Published: February 2022

Abstract
BackgroundImmune checkpoint inhibitors (ICIs) sometimes cause immune-related adverse events (irAEs), the timing of occurrence of which is difficult to predict. We created a system to safely manage the patients treated with ICIs who visit hospital during an emergency.MethodsWe utilized the Plan-Do-Check-Act (PDCA) cycle method to improve the quality of countermeasures for irAEs in the emergency room. First, an icon showing the patients treated with ICIs was developed for inclusion in electronic medical records. Second, ICI-specified urgent sets of clinical laboratory tests were prepared to cover the spectrum of irAEs. Third, a direct call system to either the attending physician or the chemotherapy team was established. A flow chart for managing irAEs has been prepared since September 2018. We retrospectively analyzed the electronic medical records from September 2018 to December 2020 to determine the effectiveness of the developed system.ResultsIn the first cycle of PDCA, 24 patients administered ICIs were retrospectively surveyed and seven visited the emergency room. Six cases were examined according to the flow chart, whereas the other patient complaining of grade 2 diarrhea were not examined because of incomplete knowledge regarding ICIs and irAEs. As part of the “Act” step, we reminded the doctors of the flow chart and gave a lecture to the residents on how to manage irAEs. During the second and seventh cycle, no cases were observed without consulting the flow chart.ConclusionsQuality improvement activities for the management of irAEs were conducted using the PDCA cycle methodology. Patients on ICIs are now being continuously monitored to further improve management quality.
Cytotoxicity of 3D Printed Materials for Potential Dental Applications: An In Vitro Study
Authors: Al Mortadi Noor A. , Al Husein Belal A. , Alzoubi Karem H. , Khabour Omar F. , Eggbeer Dominic 
Published: February 2022

Aim of the Study:
This study aims to evaluate the cytotoxicity of different stereolithographic 3D printed materials and the polyetheretherketone for varying time intervals using MTT assay and by application of these materials for intra-oral usage.

Materials and Methods:
Three groups of disc specimens (5 mm diameter, 2 mm thick) were manufactured by either selective laser melting (PA6 nylon, fiber reinforced PA6 nylon) or milling (PEEK). The cytotoxicity of these materials was tested by culturing the samples on human fibroblast cell lines prior to MTT assays (3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a yellow tetrazole). MTT assays were completed at 3, 6, and 10 days. Cell grown in normal medium without experimental material served as control. The total cell number and viability of cells pre-incubated with PA6 nylon, fiber-reinforced PA6 nylon, and PEEK were comparable to the control samples. Differences between the growth inhibitory effects of the samples in the MTT assay were below 0.05%.

Results:
Both nylon and fiber-reinforced nylon reduced the proliferation of normal human fibroblasts up to 6 days of treatment. PEEK had better biocompatibility than PA6 nylon and fiber-reinforced nylon. Both PA6 nylon and fiber-reinforced are 3DPrinted materials that showed cytotoxicity at 10 days. However, soaking the nylon materials for 6 days made them safe on normal human cells.

Conclusion:
PEEK material can be considered for intraoral usage as the material is biocompatible. Both PA6 nylon and fiber-reinforced PA6 nylon materials showed increased in-vitro cell death at 10 days, suggesting that they are non-biocompatible for intraoral usage beyond 6 days.
The Impact of Telemedicine Visits on the Controlling High Blood Pressure Quality Measure During the COVID-19 Pandemic: Retrospective Cohort Study
Authors: Ye Siqin , Anstey D Edmund , Grauer Anne , Metser Gil , Moise Nathalie , Schwartz Joseph , Kronish Ian , Abdalla Marwah 
Published: February 2022

Background
Telemedicine visit use vastly expanded during the COVID-19 pandemic, and this has had an uncertain impact on cardiovascular care quality.

Objective
We sought to examine the association between telemedicine visits and the failure to meet the Controlling High Blood Pressure (BP) quality measure from the Centers for Medicare & Medicaid Services.

Methods
This was a retrospective cohort study of 32,727 adult patients with hypertension who were seen in primary care and cardiology clinics at an urban, academic medical center from February to December 2020. The primary outcome was a failure to meet the Controlling High Blood Pressure quality measure, which was defined as having no BP recorded or having a last recorded BP of ≥140/90 mm Hg (ie, poor BP control). Multivariable logistic regression was used to assess the association between telemedicine visit use during the study period (none, 1 telemedicine visit, or ≥2 telemedicine visits) and poor BP control; we adjusted for demographic and clinical characteristics.

Results
During the study period, no BP was recorded for 2.3% (486/20,745) of patients with in-person visits only, 27.1% (1863/6878) of patients with 1 telemedicine visit, and 25% (1277/5104) of patients with ≥2 telemedicine visits. After adjustment, telemedicine use was associated with poor BP control (1 telemedicine visit: odds ratio [OR] 2.06, 95% CI 1.94-2.18; P<.001; ≥2 telemedicine visits: OR 2.49, 95% CI 2.31-2.68; P<.001; reference: in-person visits only). This effect disappeared when the analysis was restricted to patients with at least 1 recorded BP (1 telemedicine visit: OR 0.89, 95% CI 0.83-0.95; P=.001; ≥2 telemedicine visits: OR 0.91, 95% CI 0.83-0.99; P=.03).

Conclusions
Increased telemedicine visit use is associated with poorer performance on the Controlling High Blood Pressure quality measure. However, telemedicine visit use may not negatively impact BP control when BP is recorded.
Implementation of a Brief Dialectical Behavioral Therapy Skills Group in High Schools for At-Risk Youth: Protocol for a Mixed Methods Study
Authors: Zapolski Tamika , Whitener MacKenzie , Khazvand Shirin , Crichlow Queenisha , Revilla Rebecca , Salgado Eduardo F , Aalsma Matthew , Cyders Melissa , Salyers Michelle , Wu Wei 
Published: February 2022

Background
Adolescence is a developmental period marked by engagement in risk-taking behaviors, especially among impulsive or emotionally dysregulated youth. Thus, interventions that teach skills to reduce the risk of negative outcomes associated with emotional dysregulation are required. Social and emotional learning (SEL) programs have been developed to address both adolescent emotional dysregulation and risk-taking behaviors; however, current programs have mostly been implemented among younger youth and are used as a tier 1 universal intervention rather than a targeted tier 2 intervention for youth identified with emotional regulation difficulties.

Objective
This study aimed to address the need for SEL programming that can be delivered in schools, particularly for older youth who have difficulties with emotional or behavioral dysregulation, to reduce the risk of health-risk behaviors among this population.

Methods
Here, we outline the implementation of an SEL intervention titled Going 4 Goals, a 9-session adaptation of the Dialectical Behavioral Therapy for Adolescents (DBT-A) program delivered to at-risk high school students in a school setting. The primary objectives of the study are to test whether participating in the skills group intervention produces significant increases in the core DBT-A skills of mindfulness, emotional regulation, distress tolerance, and interpersonal effectiveness, while also producing significant decreases in substance use and risky behaviors. These primary outcomes are based on changes in participant scores between baseline and after the intervention and follow-ups at 1, 3, and 6 months compared with a control group of youth participating in the school’s health curriculum at the same time points. Qualitative interviews will also be conducted with intervention participants and school staff to examine acceptability and facilitators of and barriers to the intervention.

Results
A total of 171 participants across 13 groups had been enrolled in the intervention, with data collection ending December 2021. Data analysis will begin in the spring of 2022, with expected results to be published in the spring of 2023.

Conclusions
This paper describes the protocol of the 9-session school-based adaptation of the DBT-A intervention and discusses the strengths and limitations of the study and future directions.

International Registered Report Identifier (IRRID)
DERR1-10.2196/32490
Toward Human Digital Twins for Cybersecurity Simulations on the Metaverse: Ontological and Network Science Approach
Authors: Nguyen Tam N 
Published: February 2022

Background
Cyber defense is reactive and slow. On average, the time-to-remedy is hundreds of times larger than the time-to-compromise. In response, Human Digital Twins (HDTs) offer the capability of running massive simulations across multiple domains on the Metaverse. Simulated results may predict adversaries' behaviors and tactics, leading to more proactive cyber defense strategies. However, current HDTs’ cognitive architectures are underdeveloped for such use.

Objective
This paper aims to make a case for extending the current digital cognitive architectures as the first step toward more robust HDTs that are suitable for realistic Metaverse cybersecurity simulations.

Methods
This study formally documented 108 psychology constructs and thousands of related paths based on 20 time-tested psychology theories, all of which were packaged as Cybonto—a novel ontology. Then, this study applied 20 network science centrality algorithms in ranking the Cybonto psychology constructs by their influences.

Results
Out of 108 psychology constructs, the top 10 are Behavior, Arousal, Goals, Perception, Self-efficacy, Circumstances, Evaluating, Behavior-Controllability, Knowledge, and Intentional Modality. In this list, only Behaviors, Goals, Perception, Evaluating, and Knowledge are parts of existing digital cognitive architectures. Notably, some of the constructs are not explicitly implemented. Early usability tests demonstrate that Cybonto can also be useful for immediate uses such as manual analysis of hackers’ behaviors and automatic analysis of behavioral cybersecurity knowledge texts.

Conclusions
The results call for specific extensions of current digital cognitive architectures such as explicitly implementing more refined structures of Long-term Memory and Perception, placing a stronger focus on noncognitive yet influential constructs such as Arousal, and creating new capabilities for simulating, reasoning about, and selecting circumstances.
COVID-19 Mental Health Stressors of Health Care Providers in the Pandemic Acceptance and Commitment to Empowerment Response (PACER) Intervention: Qualitative Study
Authors: Sato Christa , Adumattah Anita , Abulencia Maria Krisel , Garcellano Peter Dennis , Li Alan Tai-Wai , Fung Kenneth , Poon Maurice Kwong-Lai , Vahabi Mandana , Wong Josephine Pui-Hing 
Published: February 2022

BackgroundSince the pandemic, more Canadians have reported poorer mental health. A vital group experiencing a high level of stressors consists of health care providers (HCPs) caring for COVID-19 patients, carrying out public health responses, or working with vulnerable populations. The mental health of HCPs is negatively affected by the pandemic, not only at work but also at home and in the community. Intersecting stressors at multiple levels contribute to HCPs’ experiences of fatigue, insomnia, anxiety, depression, and posttraumatic stress symptoms.ObjectiveThe aim of this qualitative study was to explore the pandemic stressors experienced by HCPs at work, at home, and in the community before participating in the Pandemic Acceptance and Commitment to Empowerment Response (PACER) online intervention.MethodsInformed by a social ecological approach, we used a qualitative reflective approach to engage 74 HCPs in diverse roles. Data were collected during the first 2 waves of the COVID-19 pandemic (June 2020 to February 2021) in Canada.ResultsInformed by a social ecological framework, 5 overarching themes were identified in our thematic analysis: (1) personal level stressors that highlight HCPs’ identities and responsibilities beyond the workplace; (2) interpersonal level stressors from disrupted social relationships; (3) organizational stressors that contributed to unsettled workplaces and moral distress; (4) community and societal stressors attributed to vicarious trauma and emotional labor; and (5) the multilevel and cumulative impacts of COVID-19 stressors on HCPs’ health.ConclusionsCOVID-19 is not merely a communicable disease but also a social and political phenomenon that intensifies the effects of social inequities. Current understanding of pandemic stressors affecting HCPs is largely partial in nature. Although workplace stressors of HCPs are real and intense, they need to be explored and understood in the context of stressors that exist in other domains of HCPs’ lives such as family and community to ensure these experiences are not being silenced by the “hero” discourses or overshadowed by professional demands.
Identifying COVID-19 Outbreaks From Contact-Tracing Interview Forms for Public Health Departments: Development of a Natural Language Processing Pipeline
Authors: Caskey John , McConnell Iain L , Oguss Madeline , Dligach Dmitriy , Kulikoff Rachel , Grogan Brittany , Gibson Crystal , Wimmer Elizabeth , DeSalvo Traci E , Nyakoe-Nyasani Edwin E , Churpek Matthew M , Afshar Majid 
Published: February 2022

Background
In Wisconsin, COVID-19 case interview forms contain free-text fields that need to be mined to identify potential outbreaks for targeted policy making. We developed an automated pipeline to ingest the free text into a pretrained neural language model to identify businesses and facilities as outbreaks.

Objective
We aimed to examine the precision and recall of our natural language processing pipeline against existing outbreaks and potentially new clusters.

Methods
Data on cases of COVID-19 were extracted from the Wisconsin Electronic Disease Surveillance System (WEDSS) for Dane County between July 1, 2020, and June 30, 2021. Features from the case interview forms were fed into a Bidirectional Encoder Representations from Transformers (BERT) model that was fine-tuned for named entity recognition (NER). We also developed a novel location-mapping tool to provide addresses for relevant NER. Precision and recall were measured against manually verified outbreaks and valid addresses in WEDSS.

Results
There were 46,798 cases of COVID-19, with 4,183,273 total BERT tokens and 15,051 unique tokens. The recall and precision of the NER tool were 0.67 (95% CI 0.66-0.68) and 0.55 (95% CI 0.54-0.57), respectively. For the location-mapping tool, the recall and precision were 0.93 (95% CI 0.92-0.95) and 0.93 (95% CI 0.92-0.95), respectively. Across monthly intervals, the NER tool identified more potential clusters than were verified in WEDSS.

Conclusions
We developed a novel pipeline of tools that identified existing outbreaks and novel clusters with associated addresses. Our pipeline ingests data from a statewide database and may be deployed to assist local health departments for targeted interventions.
Evaluation of the Dengue Surveillance System in Khyber Pakhtunkhwa Province, Pakistan, in 2020
Authors: Khan Omar Sharif 
Published: February 2022

Background
Installation and actualization of a disease surveillance system are prerequisites for early detection of outbreaks. Prompt response is possible when a robust surveillance system is in place. Dengue is one of the many diseases endemic to Pakistan and is potentially fatal.

Objective
This study aimed to assess the current dengue surveillance system and its performance and to provide recommendations to stakeholders for its actualization and improvement.

Methods
A cross-sectional study was conducted in 2020 to document the outcomes. The evaluation was guided by the updated Centers for Disease Control and Prevention guidelines for public health surveillance for the year 2019. A structured questionnaire was designed and piloted to estimate the simplicity, flexibility, acceptability, and stability of the current dengue surveillance system. The sample included 45 provincial- and district-level staff involved in dengue surveillance. Provincial data on dengue were analyzed to evaluate completeness, quality, positive predictive value, sensitivity, and representativeness. Field visits to districts were performed to assess data flow and timeliness.

Results
The reporting rate ranged from 12/100,000 in 2017 to 21/100,000 in 2019, with a total of 7641 reported cases in the province. The mean time of reporting cases was 1 day (range 0-2 days). The simplicity of the dengue surveillance system was at 90% with respect to structure and data flow. The stability of the system was at 84% because of data backup. System flexibility was at 81% and allowed the addition and modification of variables. The average completeness of the selected variables was 65%. About 59% of the staff interviewed considered the system acceptable. Data quality was suboptimal at 48%. The representativeness of the system was at 40%, and it was mainly representative of secondary and tertiary health care hospitals, particularly inpatients. The system positive predictive value for dengue was 15% and sensitivity was 14%, which were below par. The dengue surveillance system can detect dengue outbreaks early.

Conclusions
An immediate, collaborative, multisectoral, and transdisciplinary plan is needed to enhance reporting from all health facilities. Adequate government funding is needed to improve data quality, and a monitoring mechanism is needed at all levels for prompt functioning of the surveillance system.
Virtual Dermatology and the COVID-19 Pandemic in a Resource-Limited Country Such as Nepal
Authors: Jha Krishna , Jha Anil Kumar 
Published: February 2022

Background
The COVID-19 pandemic has caused nationwide lockdown, which led to the disruption of health services. Despite being a rising health care modality in Nepal, virtual dermatology services became an effective tool to provide dermatologic care through web-based consultations throughout the country. Therefore, we assessed the implementation of teledermatology services at our center to provide uninterrupted health services across the country during the pandemic.

Objective
This study aimed to evaluate the clinicodemographic profile of patients using teledermatology services and patient acceptance of this service.

Methods
A retrospective, single-center, observational study was carried out. Clinicodemographic data from the patients using teledermatology services were obtained and analyzed. A set of questionnaires regarding patients’ acceptance of teledermatology services were administered to the patients through a survey via telephone calls, and the obtained data were interpreted.

Results
A total of 122 teleconsultations were carried out within the country. The mean age of patients was 33.48 (SD 17.89) years. Of these 122 patients, 79 (64.8%) were from outside and 43 (35.2%) were from inside the city where the institute is located. The average distance from the institute to the patients’ residence was approximately 144.84 (SD 157.20) km, and the mean travel time was approximately 385.31 (SD 889.52) minutes. In total, 89 patients could be contacted, of whom 81 (91%) found the service easy to use, 75 (84.3%) were able to express their problems in a manner similar to that during direct visits, 49 (55.05 %) thought that the teleconsultation was the same as an in-person visit, 80 (89.9%) were satisfied, and 85 (95.5%) agreed to use teledermatology services in the future. Superficial fungal infection was the most common diagnosis (24.6 %). Newly registered patients were more satisfied than follow-up patients (96.36% vs 79.41%, respectively; P=.01).

Conclusions
This study highlights the importance of virtual dermatology services to deliver dermatologic care during the pandemic in Nepal. In the future, this program has a promising role in providing health care services to meet the medical needs of patients.

Conflicts of Interest
None declared.