bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facile preparation of humidity stable green γ‐cyclodextrin metal–organic framework monolith for CO2 capture
Authors: Fan Shu‐Ting , Chen Zhi‐Hui , Yang Zhang , Feng Jun‐Feng , Yu Lu‐Ping , Qiu Zhen‐Jiang , Liu Wen‐Tao , Li Bang‐Jing , Zhang Sheng 
Published: August 2022

AbstractProcessing powdered metal–organic frameworks (MOFs) into more usable forms can greatly expand their practical applications. We report a very simple and efficient method for synthesizing a green‐friendly γ‐cyclodextrin (CD)‐MOF monolith (rather than powder), without using any connectors or high temperature/pressure. Compared with the γ‐CD‐MOF‐powder, the γ‐CD‐MOF‐monolith showed much better humidity stability because the MOF particles in the γ‐CD‐MOF‐monolith were tightly packed. In addition, the CO2 adsorption test indicated that it had a higher volume adsorption capacity for CO2, with adsorption capacities of 44.04 and 36.85 cm3/cm3 at 0 and 25°C, respectively. The γ‐CD‐MOF‐monolith can maintain its porous structure and gas adsorption capacity even after 14 days of exposure to humid conditions, and the amount of CO2 absorption remains almost unchanged. This humidity stable γ‐CD‐MOF‐monolith is expected to have greater practical applications than its powdered counterpart in many applications including CO2 adsorption.
Modulating the active phase structure of NiMo/Al2O3 by La modification for ultra‐deep hydrodesulfurization of diesel
Authors: Yan Rixin , Liu Xiangqi , Liu Jixing , Zhang Lu , Zhou Shuhui , Jia Lingfeng , Hua Mingqing , Li Huaming , Ji Haiyan , Zhu Wenshuai 
Published: August 2022

AbstractHerein, a series of mesoporous NiMo/LaAlOx with various La contents were constructed through a solvent evaporation‐induced self‐assembly protocol, and their catalytic activities were investigated for hydrodesulfurization (HDS) of 4,6‐DMDBT. It has been confirmed that the incorporation of La influences the electronic structure and morphology of NiMoS active phase. The lower amount of La (x ≤ 1.0 wt.%) could facilitate the formation of “Type II” NiMoS phase by weakening the interaction of Mo‐O‐Al leakage and promoting the sulfidation of both Mo and Ni species as well as increasing the ratio of “Type II” NiMoS phase, thereafter boosting the HDS performances. Further increasing La incorporation, however, leads to the generation of inactive NiSx phase and decrease of NiMoS active phase proportion, the HDS activities of corresponding catalysts were suppressed. NiMo/LaAlOx‐1.0 exhibits the highest activity for 4,6‐DMDBT HDS because of its moderate metal‐support interaction, optimal morphology and the largest proportion of “Type II” NiMoS active phase.
Lymphatic anomalies during lifetime in patients with Noonan syndrome: Retrospective cohort study
Authors: Swarts Jessie W. , Kleimeier Lotte E. R. , Leenders Erika K. S. M , Rinne Tuula , Klein Willemijn M. , Draaisma Jos M. T. 
Published: August 2022

AbstractNoonan syndrome (NS) has been associated with an increased risk of lymphatic anomalies, with an estimated prevalence of 20%. The prevalence of lymphatic anomalies seems to differ between pathogenic variants. Therefore, this study aims to describe the clinical presentation, prevalence and genotype–phenotype correlations of lymphatic anomalies during life in patients with NS. This retrospective cohort study included patients (n = 115) who were clinically and genetically diagnosed with NS and visited the Noonan expertise Center of the Radboud University Medical Center between January 2015 and March 2021. Data on lymphatic anomalies during lifetime were obtained from medical records. Lymphatic anomalies most often presented as an increased nuchal translucency, chylothorax and/or lymphedema. Prenatal lymphatic anomalies increased the risk of lymphatic anomalies during infancy (OR 4.9, 95% CI 1.7–14.6). The lifetime prevalence of lymphatic anomalies was 37%. Genotype–phenotype correlations showed an especially high prevalence of lymphatic anomalies during infancy and childhood in patients with a pathogenic SOS2 variant (p = 0.03 and p < 0.01, respectively). This study shows that patients with NS have a high predisposition for developing lymphatic anomalies during life. Especially patients with prenatal lymphatic anomalies have an increased risk of lymphatic anomalies during infancy. Genotype–phenotype correlations were found in pathogenic variants in SOS2.
Parenchymal Hemorrhage Rate Is Associated with Time to Reperfusion and Outcome
Authors: Olivot Jean‐Marc , Finitsis Stephanos , Lapergue Bertrand , Marnat Gaultier , Sibon Igor , Richard Sebastien , Viguier Alain , Cognard Christophe , Mazighi Mikael , Gory Benjamin ,   the ETIS Registry Investigators
Published: August 2022

ObjectiveDespite a 90% reperfusion rate, only 50% of patients with anterior circulation large vessel occlusion‐related acute ischemic stroke (LVO‐AIS) have a functional recovery at 3 months. Parenchymal hematoma (PH) is a predictor of poor outcome after endovascular treatment (EVT). We aim to investigate the relationship between the delay from onset to reperfusion, the occurrence of PH, and functional outcome.MethodsThe Endovascular Treatment in Ischemic Stroke (ETIS) registry is an ongoing prospective observational study. Data were analyzed from the subgroup of patients who underwent a successful EVT defined by a modified Thrombolysis in Cerebral Infarction (mTICI) score 2b‐3. We assessed the factors associated with PH, (ie, PH1 or PH2 grade according to the European Collaborative Acute Stroke Study 2 (ECASS) classification of hemorrhagic transformation), then evaluated the relationships between PH, delay from onset to reperfusion, and functional recovery defined by a modified Rankin Scale (mRS) of 0–2.ResultsWe analyzed 2,919 patients with an LVO‐related AIS who underwent a successful EVT. Overall, 13.3% of the participant experienced a PH. The rate of PH increased by 2.5% (95% CI 1.5%–3.6%, p < 0.001) for every additional hour of onset to reperfusion delay and was, by comparison with the other study patients, consistently associated with a lower rate of functional recovery 19.7% (95% CI 11.6%–27.7%, p < 0.001) irrespective of time from onset to reperfusion.InterpretationOur results demonstrate that PH rate is associated with the delay from onset to reperfusion and participates in the relationship between time to reperfusion and outcome. Time is Bleeding. ANN NEUROL 2022;92:882–887
Engineering Supramolecular Binding Sites in a Chemically Stable Metal‐Organic Framework for Simultaneous High C2H2Storage and Separation
Authors: Shao Kai , Wen Hui‐Min , Liang Cong‐Cong , Xiao Xiaoyan , Gu Xiao‐Wen , Chen Banglin , Qian Guodong , Li Bin 
Published: August 2022

AbstractDeveloping porous materials to overcome the trade‐off between adsorption capacity and selectivity for C2H2/CO2separation remains a challenge. Herein, we report a stable HKUST‐1‐like MOF (ZJU‐50a), featuring large cages decorated with high density of supramolecular binding sites to achieve both high C2H2storage and selectivity. ZJU‐50a exhibits one of the highest C2H2storage capacity (192 cm3 g−1) and concurrently high C2H2/CO2selectivity (12) at 298 K and 1 bar. Single‐crystal X‐ray diffraction studies on gas‐loaded ZJU‐50a crystal unveil that the incorporated supramolecular binding sites can selectively take up C2H2molecule but not CO2to result in both high C2H2storage and selectivity. Breakthrough experiments validated its separation performance for C2H2/CO2mixtures, providing a high C2H2recovery capacity of 84.2 L kg−1with 99.5 % purity. This study suggests a novel strategy of engineering supramolecular binding sites into MOFs to overcome the trade‐off for this separation.
Enhanced thermal conductivity and insulation properties of mica tape with BN coating via electrostatic spraying technology
Authors: Feng Yu , He Ziyuan , Yang Zhijie , Tang Wenxin , Chi Qingguo , Chen Qingguo 
Published: August 2022

AbstractThe bottleneck problem of the development of high‐voltage motors to a larger capacity can be solved if the thermal conductivity is improved without sacrificing the insulation characteristics of the main insulation material. In this paper, a spraying technology based on electrospinning is proposed that can evenly spray boron nitride (BN) with high thermal conductivity onto the surface of mica tape. With the increase in BN content, the insulation and thermal conductivity of mica tape are optimized to varying degrees. When the BN content reaches 2.25 wt%, the in‐plane conductivity increases from 1.6 to 2.7 w/(m K), while the out‐of‐plane conductivity increases from 0.17 to 0.26 w/(m K). Additionally, the direct‐current (DC) breakdown strength has increased from 90.6 to 96.9 kV/mm and the dielectric constant and dielectric loss are almost unchanged. Finally, through simulation verification, if the modified mica tape is applied to the main insulation of a synchronous motor, the operating temperature of the motor insulation will be reduced from 73.5 to 66.1°C. This study provides a new research idea for the preparation of high thermal conductivity insulating materials.
The possible role of the nucleoside adenosine in countering skin aging: A review
Authors: Marucci Gabriella , Buccioni Michela , Varlaro Vincenzo , Volpini Rosaria , Amenta Francesco 
Published: August 2022

AbstractSkin aging is a complex biological process. Skin aspect is considered as a sign of well‐being and of beauty. In view of this, noninvasive and/or minimally invasive anti‐aging strategies were developed. Adenosine, a well‐known nucleoside, may play a role in skin rejuvenation. Adenosine receptors belong to the G protein‐coupled receptors superfamily and are divided into four subtypes: A1, A2A, A2B, and A3. The adenosine receptors expressed by skin are mainly the A1 and A2A subtypes. In the hypodermis, adenosine through the A1 receptor stimulates lipogenesis and adipogenesis. In the dermis, adenosine through the A2A receptor subtype stimulates collagen production. Moreover, the nucleoside increases new DNA synthesis and subsequently protein synthesis in dermal cells. Activation of adenosine receptors by interacting with various skin layers may induce a decrease in the amount of wrinkles, roughness, dryness, and laxity. This article has reviewed the mechanisms through which adenosine modulates biological mechanisms in the skin tissues and the effect of preparations containing adenosine or its derivatives on the skin.
Association strength of E6 to E6AP/p53 complex correlates with HPV‐mediated oncogenesis risk
Authors: Ferraz Matheus Vitor Ferreira , Viana Isabelle Freire Tabosa , Coêlho Danilo Fernandes , da Cruz Carlos Henrique Bezerra , de Arruda Lima Maíra , de Luna Aragão Madson Allan , Lins Roberto Dias 
Published: August 2022

AbstractHuman papillomavirus (HPV) is recognized as the causative agent of cervical cancer in women, and it is associated with other anogenital and head/neck cancers. More than 120 types of HPV have been identified and many classified as high‐ or low‐risk according to their oncogenic potential. One of its proteins, E6, has evolved to overcome the oncosuppressor functions of p53 by targeting this protein for degradation via interaction with the human ubiquitin‐ligase E6AP. This study evaluates the correlation between the association strength of 40 HPV E6 types to the E6AP/p53 complex and the HPV oncogenesis risk using molecular simulations and machine and deep learning (ML/DL). In addition, a ML/DL‐driven prediction is proposed for the HPV unclassified oncogenic risk type. The results indicate that thermodynamics play a pivotal role in the establishment of HPV‐associated cancer and highlight the need to include some viral types in the HPV‐related cancer surveillance and prevention strategies.
Effect of bridging units on the photophysical properties of 4‐NEt2‐appended salen−indium complexes
Authors: Mubarok Hanif , Kwak Sang Woo , Lee Ji Hye , Hwang Hyonseok , Lee Kang Mun , Kim Youngjo , Lee Min Hyung , Park Myung Hwan 
Published: August 2022

AbstractA series of 4‐NEt2‐appended salen−indium complexes bridged by different diimine units (ethylene [Et, 1], phenylene [Ph, 2], and benzonitrile [PhCN, 3]) with different electronic effects were prepared in high yields by a one‐pot synthetic procedure. Among them, the solid‐state structure of 1 was identified by X‐ray crystallography, featuring a square‐pyramidal structure around the indium center. Ultraviolet–visible (UV/Vis) absorption and emission spectra of 1–3 showed typical ππ* electronic transitions centered on the salen ligands, which underwent gradual redshifts as the electron‐withdrawing ability of the bridging units increased. Such bathochromic shifts resulted from lowering the energy levels of the lowest unoccupied molecular orbital (LUMO). In addition, the full width at half maxima for the emissions of 1–4 gradually decreased with increasing electron‐accepting property of the bridging units. The observed photophysical properties were further supported by theoretical calculations.
Sustainable development considerations in supply chains: Firms' relationships with stakeholders in their business sustainability practices—A triangular comparison
Authors: Andersson Svante , Svensson Göran , Otero‐Neira Carmen , Laurell Hélène , Lindgren John , Karlsson Niklas P. E. 
Published: August 2022

AbstractThis study aims to investigate focal firms' business sustainability relationships in connection with their stakeholders in supply chain networks. A questionnaire survey was sent to a sample consisting of large Swedish firms, with 107 usable questionnaires returned. The results reveal which stakeholders are of interest for firms in sustainability efforts. The results are compared with earlier findings from Norway and Spain in a triangular approach. The former is a similar country, while the latter is different to Sweden in several ways. In addition, the study uncovers which stakeholders in the supply chain network should be considered. The study also demonstrates how firms can implement business sustainability in their supply chain networks and shows the extent to which different stakeholders are considered in sustainability efforts. The study contributes to sustainability research and stakeholder theory in supply chain networks. Opposite to earlier findings, this study showed only minor influences from national culture and institutions on firms' sustainable business practices in supply chain networks.
Learning frequency‐aware convolutional neural network for spatio‐temporal super‐resolution water surface waves
Authors: Peng Chen , Tu Zaili , Qiu Sheng , Li Chen , Wang Changbo , Qin Hong 
Published: August 2022

AbstractAs a usual component in virtual scenes, water surface plays an important role in various graphical applications, including special effects, video games, and virtual reality. Although recent years have witnessed significant progress based on Navier–Stokes equations and simplified water models, large‐scale water surface waves with high‐frequency visual details remain computationally expensive for interactive applications. This article proposes a novel frequency‐aware neural network to synthesize consistent and detailed water surface waves from low‐resolution input. At its core, our approach leverage the wavelet transformation theory over space, frequency and direction, and incremental supervision to decompose the 4D amplitude function into multiple smaller subproblems. Specifically, we first customize four subnetworks and corresponding loss functions for super‐resolution of spatial resolution, temporal evolution, wave direction subdivision, and wave number, respectively. Then, to enforce the upsampling along each dimension orthogonal to each other, we introduce a cooperative training scheme to fine‐tune and integrate the proposed subnetworks with carefully designed training dataset. Our method can visually enhance high‐resolution spatial details, temporal coherence, interactions with complex boundaries, and various wave patterns with flexible control along multiple dimensions. Through extensive experiments, our method arrives at 13 speedup for 32 upsampling of various simulation scenarios. We also validate the effectiveness and robustness of our method to produce realistic water surface waves toward artistic innovation.
Engagement estimation of the elderly from wild multiparty human–robot interaction
Authors: Zhang Zhijie , Zheng Jianmin , Magnenat Thalmann Nadia 
Published: August 2022

AbstractThe use of social robots in healthcare systems or nursing homes to assist the elderly and their caregivers will be becoming common, where robots' understanding of engagement of the elderly is important. Traditional engagement estimation (EE) often requires expert involvement in a controlled dyadic interaction environment. In this article, we propose a supervised machine learning method to estimate the engagement state of the elderly in a multiparty human–robot interaction (HRI) scenario from the real‐world video recording as input. The method is built upon the basic concept of engagement in geriatric psychiatry and HRI video representations. It adapts pretrained models to extract behavior, affective, and visual signals to form the multi‐modal features. These features are then fed into a neural network made of a self‐attention mechanism and average pooling for individual learning, a graph attention network for group learning and a fully connected layer to estimate the engagement. We tested the proposed method using 43 wild multiparty elderly robot interaction (ERI) videos. The experimental results show that our method is capable of detecting the key participants and estimating the engagement state of the elderly effectively. Also our study demonstrates the signals from side‐participants in the main interaction group considerably contribute to the EE of the elderly in the multiparty ERI.
Two Species Origins Comparison of Herba Patriniae Based on Their Ingredients Profile by UPLC‐QTOF/MS/MS and Orthogonal Partial Least Squares Discriminant Analysis
Authors: Su Dan , Yang Yanyan , Zeng Qiang , Liao Liangliang , Chen Changlian , Yang Ming , Zhu Genhua , Zhang Ruo‐Wen , Ai Zhifu , Li Yanzhen , Song Yonggui 
Published: August 2022

AbstractHerba Patriniae (HP) is widely used as a medicinal and edible material in China. Besides food value, HP attracts more attention due to its medicinal potential.Patrinia villosaJuss. (PV) andPatrinia scabiosaefoliaFisch. (PS) are the two species origins of HP. These two of HP show different effects on cell proliferation, migration, angiogenesis and anti‐diabetic. As we have previously reported,PVandPSshow significant differences on their anti‐inflammatory ability in the same experimental model. Comparing the ingredient profiles of two different sources will not only facilitate the understanding of their medicinal effects, but also help the development and research of new activities. However, still now, there is no systematic and detailed study to compare the components ofPVandPS. In present study, ultra‐high performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry was employed to achieve a high‐throughput qualitative and thorough analysis of the chemical composition spectrum of HP. A total of 164 compounds were identified, among these compounds, 127 compounds were identified fromPV, and 107 compounds were identified fromPS. Most of the chemical components was discovered for the first time. Flavonoids, saponins, terpenoids and organic acids, as the main ingredients inPVandPSwere 45.45 %vs 28.46 %, 12.61 %vs. 32.09 %, 14.33 %vs. 22.38 % and 14.58 %vs. 6.79 %, respectively. Flavonoids are the main components ofPV, whilePSis rich in saponins.PVandPSwere classified into two groups by principal component analysis (PCA) and screened out the main molecular differences responsible by orthogonal partial least squares discriminant analysis (OPLS‐DA). All the results will be a guide for the quality control, functional activity research, or better clinic use based on the ingredients profile between these two species. Besides, this first study on ingredients profile of two species origins will be beneficial for potential and best resources utilization of bothPVandPS.
GC/MS‐Based Fingerprinting Reveals Two Chemotypes in the Leaf Essential Oils fromMagnolia grandifloraTrees within The Urban Forestry of a Colombian Andean Plateau
Authors: Bernal Freddy A. , Matulevich Javier A. , Corredor John A. , Coy‐Barrera Ericsson 
Published: August 2022

AbstractMagnolia grandiflorais an aromatic plant widely distributed around the world. In Colombia, and more specifically in Bogotá,M. grandiflorahas been introduced as part of urban forestry programs, and their specimens are therefore subjected to several environments. Nevertheless, there are no previous studies on the chemical composition of such plants. Hence, the characterization of the essential oil from 20 specimens ofM. grandiflorafrom Bogotá, Colombia, by GC/MS was carried out here. Two different chemotypes were found. While one was characterized by monoterpenes α‐pinene, β‐pinene, and limonene, the other contained mainly sesquiterpenes β‐elemene, bicyclogermacrene, and germacrene D. Multivariate statistical analyses confirmed their existence and helped to identify variations within and between chemotypes. Furthermore, differential expression of genes encoding the terpene synthasesMg25 andMg17 could arguably be responsible for the characteristic compositions of both chemotypes, as suggested by rational biosynthetic analysis of the most contrasting metabolites.
Targeting Epstein‐Barr Virus dUTPase, an Immunomodulatory Protein Using Antiviral, Anti‐Inflammatory, and Neuroprotective Phytochemicals
Authors: Tiwari Deeksha , Murmu Sneha , Indari Omkar , Chandra Jha Hem , Kumar Sunil 
Published: August 2022

AbstractAlthough primary infection of Epstein‐Barr virus is generally non‐lethal, viral reactivation is often associated with fatal outcomes. Regardless, there is no FDA‐approved treatment available for this omnipresent viral infection. The current investigation targets viral maintenance and reactivation by inhibiting the functioning of viral deoxyuridine‐triphosphatase (dUTPase) using phytochemicals. The EBV‐dUTPase is essential for maintaining nucleotide balance and thus, plays a vital role in the viral replication cycle. Additionally, the protein has shown neuroinflammatory effects on the host. To selectively target the protein and possibly alter its activity, we utilized a virtual screening approach and screened 45 phytochemicals reported to have antiviral, anti‐inflammatory, and neuroprotective properties. The analysis revealed several phytochemicals bound to the target protein with high affinity. In‐silico ADMET and Lipinski's rule analysis predicted favorable druggability of Dehydroevodiamine (DHE) among all the phytochemicals. Further, we corroborated our findings by molecular dynamic simulation and binding affinity estimation. Our outcomes ascertained a stable binding of DHE to EBV‐dUTPase primarily through electrostatic interactions. We identified that the protein‐ligand binding involves the region around His71, previously reported as a potent drug target site. Conclusively, the phytochemical DHE showed a promising future as a drug development candidate against EBV‐dUTPase.