bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laboratory Analysis of the Anti-Infectious Activity of Quantum Dots and Bioconjugates Based on Them against a Potential Eye Pseudomonas Aeruginosa Infection. Experimental Research (Part 4)
Authors: Ponomarev V. O. , Kazaykin V. N. , Lizunov A. V. , Rozanova S. M. , Kirf M. V. , Tkachenko K. A. 
Published: July 2022

This article is a continuation of a series of publications on the results of an experimental study on the possibilities of using quantum dots, as well as bioconjugates based on them as a promising treatment for inflammatory diseases of the eye. Of the whole variety of microorganisms, Pseudomonas aeruginosa (Pa) is the most formidable pathogen, leading to pronounced, sometimes fatal, changes throughout the body in general, and in the eye in particular, in connection with which it receives close attention from bacteriologists and specialists dealing with the treatment of pathologies caused by this microorganism. Now, the search for effective methods to combat this pathogen is one of the priorities of world health care.This article presents an analysis of the anti-infectious activity of bioconjugates based on quantum dots KTCdTe / CdMPA710 and KTInP / ZnSe / ZnS650 in synergy with III generation cephalosporin (Cefotaxin) against nosocomial Pa strains. Cultures of microorganisms, in the amount of 30 Petri dishes, were incubated in a thermostat at 350C for 18 hours (in the dark and under a source of photoexcitation). As a source of photoexcitation (the emission spectrum of the source corresponded to the absorption spectrum of QDs), we used an LED strip connected to an uninterruptible power supply battery placed in a thermostat. Evaluation of the effectiveness of the impact was carried out using the disk-diffusion method with the measurement of effective growth retardation zones (GRZ). According to the results of the study, it was revealed that the use of the obtained bioconjugate (QD + AB) significantly increases the ZZR.
Modified Immediate Sequential Bilateral Cataract Surgery (Clinical Cases)
Authors: Medvedev I. B. , Pokrovsky D. F. 
Published: July 2022

Purpose. Analysis of two clinical cases of immediate sequential bilateral cataract surgery according to the developed modified algorithm (mаISBCS).Materials and methods. The results of two clinical cases of mаISBCS are presented. In both cases, ultrasonic cataract phacoemulsification (FEC) was performed with implantation of an intraocular lens (IOL) under local anesthesia according to the standard technique through a corneal incision of 2.2–2.4 mm. IOL calculation was performed for emmetropic refraction. The modification (compared to the traditional one) of the technology of surgical intervention was based on the inclusion in the algorithm of a long (at least 60 minutes) break between operations for the purpose of a comprehensive ophthalmological examination with a further decision to perform an operation on the second eye.Results. In the first clinical case, the patient failed to measure the anterior-posterior axis by optical biometry before surgery. In such situations, the A-scan is used, which is considered less accurate due to human error and often leads to errors in the calculation of the IOL. In addition, a certain alertness was introduced by the fact of a significant (4 diopters) difference in the preoperative refraction of both eyes. Considering these provisions, after the first operation, after 60 minutes, the correctness of the IOL calculation was monitored by two methods — by measuring (optical biometrics) the anterior-posterior axis of the eye (APA, while the differences were less than 0.3 mm, which confirmed the A-scan data), as well as autorefractometry, which showed almost no deviation from the “target”. The presented results allowed us to formulate a decision to carry out the second operation. In the second clinical case, despite the absence of risk factors (optical biometrics was taken in two eyes, similar APA values), a postoperative refraction of +1.5 diopters was determined in the operated eye, which, apparently, is associated with the identified decrease (by 0.93 diopters) corneal curvature due to hydration of the corneal stroma in the area of surgical accesses and (or) changes in the tear film. The presented results allowed us to formulate a decision to postpone the second operation. At the same time, after a week, the restoration of the corneal tissue was noted, which was proved by the required (0.37 diopters) deviation of refraction from the target values.Conclusion. The use of mаISBCS technology provides the required clinical efficacy and can be recommended taking into account the epidemiological situation, especially for people with visually strenuous work.
Acontecimientos vitales estresantes en mujeres trabajadoras de un mercado del estado de Veracruz, México
Authors: Valdez Melo Zaid , Pérez Olmedo Yoselin , Lavoignet Blanca , Cruz Núñez Fabiola , Hernández Landaverde Claudia 
Published: July 2022

Resumen
Introducción: Los acontecimientos vitales estresantes (AVE), se consideran como acontecimientos discretos que surgen en un momento exacto de la vida y que afectan la salud física y mental de quien los vive.
Objetivo: Identificar el nivel de estrés, conocer los AVE que más predominan, y determinar la relación entre las variables sociodemográficas y laborales y los AVE.
Métodos: Estudio con enfoque cuantitativo, tipo de estudio descriptivo, transversal y correlacional con una muestra de 60 mujeres trabajadoras de un mercado. Muestreo no probabilístico por conveniencia, para el análisis de los datos se utilizó estadística descriptiva (frecuencias y porcentajes) e inferencial (Rho de Spearman). Se aplicó un cuestionario ad hoc para las variables sociodemográficas y laborales y la Escala de Estrés o Reajuste Social de Holmes y Rahe.
Resultados: Presencia de estrés en nivel severo, moderado y leve, y los AVE que más predominaron son de tipo laboral, de salud y hogar/familia.
Conclusiones: Los AVE que predominaron son de tipo laboral, de salud y hogar/familia
Ideología y realidad
Authors: Calderón González Jacinto H. 
Published: July 2022

Resumen.
El presente artículo quiere dar cuenta del conflicto que presentan las ideologías cuando toman como referencia la realidad y la convierten en algo vacío. Para ello se examinan algunas de las tácticas de las ideologías: la producción de discursos, la idea de la propaganda, la conciencia de los ciudadanos, la identificación del contrario y los problemas derivados de la relación abstracto-concreto. De este modo, se pretende hacer que incluso hoy día las ideologías tienen mucho peso y funcionan como sustitutivas de la realidad.
Perspectives on the Use of Transthoracic Echocardiography Results for the Prediction of Ventricular Tachyarrhythmias in Patients with Non-ischemic Cardiomyopathy
Authors: Ilov N. N. , Stompel D. R. , Boytsov S. A. , Palnikova O. V. , Nechepurenko A. A. 
Published: July 2022

Aim. To perform a comparative analysis of indicators of transthoracic echocardiography (TE), to establish echocardiographic predictors and their predictive role in the occurrence of stable ventricular tachyarrhythmia (VT) paroxysms in patients with nonischemic chronic heart failure (HF) and cardioverter-defibrillator (ICD) implanted for primary prevention of sudden cardiac death.Material and Methods. A prospective study was carried out, which included 166 patients with nonischemic HF at the age of 54 (49; 59) years with the left ventricle ejection fraction (LV EF) ≤35% and an ICD implanted. The observation time was 24 months. The primary endpoint was the first-ever stable paroxysm of VT (lasting for ≥30 seconds), detected in the «monitor» zone of VT, or paroxysm of VT, which required ICD therapy. A total of 34 TE indicators were evaluated. Chi-square, Fischer, Manna-Whitney, single-factor logistic regression (LR), and multi-factor LR were used for data processing and analysis and for predictive modelling. Model accuracy was estimated using 4 metrics: ROC curve area (AUC), sensitivity, specificity and diagnostic efficiency.Results. During the two-year observation, 32 patients (19.3%) had a primary endpoint. The average time of occurrence of a stable VT episode was 21.6±0.6 months (95% confidence interval [CI] 20.5-22.8 months). The value of LV end-systolic dimension was the only parameter independently associated with VT (odds ratio 2.8 per unit increase, 95% CI 1.04-7.5; p=0.042). The complex analysis of echocardiographic indicators made it possible to identify 5 factors with the greatest predictive potential, which are linearly and nonlinearly related to occurrence of VT. These included the LV end-diastolic and end-systolic volumes, LV mass, index of relative LV wall thickness, upper-lower size of the right atrium. The metrics of the best predictive model were: AUC – 0.71 0.069 with 95% CI 0.574-0.843; specificity 50%, sensitivity 90.9%; diagnostic efficiency 57.1%.Conclusion. The study made it possible to evaluate the possibilities of the results of TE in predicting the probability of VT occurrence in patients with nonischemic HF and reduced LV EF. Predictive indicators have been identified that can be used to stratify the arrhythmic risk in the exposed cohort of patients.
Risk of Venous Thromboembolic Complications in Patients with Atrial Fibrillation: a Systematic Review and Meta-analysis
Authors: Sokolova A. A. , Kudriavtseva A. A. , Kostokova N. V. , Zaikina M. P. , Gebekova Z. A. , Napalkov D. A. , Zolotukhin I. A. 
Published: July 2022

Aim: The aim of this meta-analysis and systematic review was to evaluate the possible connection between AF and VTE.Material and methods. Atrial fibrillation (AF) and atrial flutter (AFL) contribute to intra-atrial blood stasis which leads to thrombus formation with its embolization. There is some evidence that AF can be a risk factor for deep vein thrombosis (DVT) and pulmonary embolism (PE). The following databases were searched: PubMed (MEDLINE), EMBASE, Google Scholar, the Cochrane Central Register of Controlled Trials. The time frame for conducting a systematic literature search ranged from January 1, 1990 to November 1, 2021. The diagnosis of atrial fibrillation had to be confirmed by using ECG. The diagnosis of VTE could be made with Doppler imaging, ventilation/perfusion scan, CT angiography, venography, angiography or autopsy. Only the three studies with 102192 patients meeting the requirement were included in the meta-analysis.Results. The prevalence of DVT and PE were assessed using incidence rate ratios (IRR) method of the inverse variance random effects model and its 95% confidence interval (CI). The significant association between atrial fibrillation and pulmonary embolism was found (IRR, 4.18 95% Cl 1.958.98). Also there is obvious association between DVT and AF (IRR, 2.97 95% Cl 2.18-4.03).Conclusion. It can be concluded that the increased risk of developing VTE is associatedwith concomitant AF.
Association of Heart Rate Variability with the Psychosocial Stress Level in Men 41-44 Years Old Living in Moscow
Authors: Drapkina O. M. , Rozanov V. B. , Kontsevaya A. V. , Isaykina O. Yu. , Muromtseva G. A. , Kotova M. B. , Akarachkova E. S. 
Published: July 2022

Aim. Research of the association of heart rate variability (HRV) with the level of psychosocial stress (PS) and other indicators of the risk of cardiovascular diseases in a sample of 41-44-year-old men living in Moscow.Material and methods. A total of 299 men aged 41-44 years were examined. The study included a clinical examination and a survey using a standard questionnaire. The categorization of risk factors (RF) for cardiovascular diseases (CVD) was carried out in accordance with generally accepted criteria The psychosocial stress was assessed using the Reeder scale. Depending on the psychosocial stress level, all surveyed men were divided into 3 groups by terciles: group 1 (3,28-4,0 points) – mild stress, group 2 (2,71-3,14) – moderate stress, group 3 (1,28-2,57) – severe stress. The analysis of HRV was performed on the basis of a short recording of an electrocardiogram using the original software package.Results. Nonparametric ANOVA showed that the mean [M (95% CI)] values of the HRV time domain (SDNN, rMSSD and the state of regulatory reserves) were lower in the group of men with high PS compared with the group with low PS [25.3 ms (20.9-29.7) versus 40.5 ms (30.7-50.3), p=0.007; 29.5 ms (24.6-34.3) versus 49.5 ms (36.7-62.3), p=0.030; and 46.7 (44.7-48.6) versus 49.7 (48.1-51.4), p=0.019; respectively]. On the contrary, the mean values [M (95% CI)] of the integral indicators of HRV (SI and IVR) were higher in the group of men with high PS [635.8 c.u. (556.2-715.4) versus 488.9 (423.8-554.1), p=0.005; 1172.6 (1045.1-1300.1) versus 904.7 (790.0-1019.4), p=0.003; respectively]. The results of correlation and multiple regression analysis confirmed that these HRV indicators are statistically significantly associated not only with PS, but also with other indicators (age, waist / hip ratio, diastolic blood pressure). However, their predictive value turned out to be low, and the proportion of the explained variance of HRV indices ranged from 2.5 to 13.1%.Conclusion. The weakening of the autonomous regulation of the heart rate with a decrease in the activity of the parasympathetic link, the activation of the central circuit of regulation with the prevalence of sympathetic influences, a decrease in the functional reserves of the heart rate regulation system are associated with an increase in the level of PS and other indicators of the risk of cardiovascular diseases.
Self-care as the Basis of the Mobile Application for Patients with Chronic Coronary Syndromes
Authors: Laskova A. I. , Frolov M. Yu. , Orlova Yu. A. , Lopatin Yu. M. 
Published: July 2022

Aim.To evaluate the impact of a mobile application usage on the self-care skills, quality of life, adherence to treatment, as well as the psychological characteristics of comorbid patients with stable coronary heart disease.Material and methods. The study will include patients over 18 years of age with an established diagnosis of ischemic heart disease, exertional angina pectoris I-IV CCS functional class, who have the technical ability to use the mobile application "B2Doc: Angina" on their smartphone. This mobile application contains main components of recommendations for the management of coronary heart disease and monitoring of patient’s well-being. The program is based on the previously developed and validated questionnaire of the self-care ability of patients with coronary artery disease. The mobile application includes advice of the day, tracking the dynamics of angina pectoris symptoms, blood pressure and pulse, a medication diary as well as educational material about coronary heart disease. The study will assess quality of life: general (SF-36) and angina-related (Seattle Angina Questionnaire), self-care skills using the Self-Care of Coronary Heart Disease Inventory questionnaire. The primary endpoints will be cardiovascular events (cardiovascular death, acute myocardial infarction, acute cerebrovascular accident, hospitalization with unstable angina or decompensated chronic heart failure) and death from all causes. Endpoints will be evaluated in 1, 3, 6 and 12 months after discharge.Expected results. We expect that the use of the mobile application "B2Doc: Angina" by patients will improve their self-care skills and quality of life, as well as increase awareness of the disease.Conclusions. The use of the newly developed mobile application "B2Doc: Angina" is a potential tool for the prevention and treatment of coronary heart disease. It represents a promising solution for the rapid implementation and expansion of telemedicine practice.
Lipid profile of patients with arterial hypertension who underwent COVID-19: possibilities of drug therapy/ LEADER
Authors: Zolotovskaya I. A. , Kuzmin V. P. , Rubanenko O. A. , Shatskaya P. R. , Salasyuk A. S. 
Published: July 2022

Aim.To study the dynamics of the lipid profile of hypertensive patients with dyslipidemia who underwent COVID-19.Material and methods. Hypertensive patients with dyslipidemia who underwent COVID-19 [n=126; 58 men and 68 women; median age 60 (56.0; 65.5) years] examined. Patients were included into two groups: group 1 (n=64) received a single pill combination of lisinopril + amlodipine + rosuvastatin; 2 groups (n=62) continued the previous drug treatment. Clinical, demographic, office blood pressure (BP), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol, triglycerides, C-reactive protein (CRP) levels were assessed in all patients in 3 visits within 24 weeks.Results.The groups did not differ in prior antihypertensive therapy (except for more frequent use of angiotensin II receptor blockers in group 2, p<0.05), lipid profile and blood pressure parameters at study entry. A decrease in systolic (by 9.5%) and diastolic blood pressure (by 12.1%) after 24 weeks was found in group 1 compared with 4.29% and 5.56%, respectively, in group 2 (p<0.05). A decrease in the level of total cholesterol by 14.5% and LDL-c by 31.4% after 24 weeks was found in group 1 compared with 11.2% and 9.7%, respectively, in group 2 (p<0.05). The level of CRP during the observation period decreased by 53.7% in group 1 versus 43.4% in patients of group 2 (p<0.05).Conclusion.The single pill combination of lisinopril/amlodipine/rosuvastatin in hypertensive patients with dyslipidemia who underwent COVID-19 led to an improvement in lipid profile and blood pressure control.
Assessment of the Quality of Drug Therapy in Patients with Stable Coronary Artery Disease in the Second Stage of the ALIGN Study
Authors: Zharkova E. D. , Martsevich S. Yu. , Lukina Yu. V. , Kutishenko N. P. , Drapkina O. M. 
Published: July 2022

Aim. To assess adjusted pharmacotherapy for prescribing drugs of the main classes, according to clinical guidelines, and achieving target levels of lowdensity lipoprotein cholesterol (LDL-C) in patients with stable coronary heart disease (CHD).Material and methods. Of the 73 patients included in the ALIGN study, 64 patients (53 males and 11 females; mean age 68,2±9,4 years) with stable coronary artery disease attended a second visit (3 months after the initial treatment adjustment). Prescribed drug therapy, its compliance with clinical guidelines, achievement of lipid profile and blood pressure (BP) targets were studied in all patients.Results. An increase in the frequency of taking beta-blockers (p=0.002), lipid-lowering drugs (p=0.008) by patients was found during the second visit. The proportion of patients taking all 4 groups of drugs according to clinical guidelines (statins, antiplatelet agents, beta-blockers, angiotensinconverting enzyme inhibitors / angiotensin II receptor blockers) increased from 44% to 65.5% (p<0.001) after correction of therapy, as well as an increase in the proportion of patients taking 1 antianginal drug in the presence of exertional angina from 75% to 89% (p<0.001) was found. About 90% of hypertensive patients achieved the target level of systolic blood pressure (p<0.001). Achievement of the target level of cholesterol low density lipoprotein (<1.8 mmol/l) during the second visit was found in half of the patients (p=0.004).Conclusion. Despite the initial correction of drug therapy by the staff of the cardiology department, the prescribed treatment for patients with stable coronary artery disease did not in all cases comply with clinical guidelines due to insufficient adherence of doctors and insufficient adherence of patients to prescribed medical recommendations.Working group of the register PROFILE: Voronina V. P., Dmitrieva N. A., Komkova N. A., Zagrebelny A.V., Kutishenko N.P., Lerman O.V., Lukina Yu. V., Tolpygina S.N., Martsevich S.Yu.
Study the Association of Nucleotide Polymorphisms in Platelet Receptor and Cytochrome P450 Genes with the Development of Resistance to Antiplatelet Drugs in Patients with Coronary Artery Disease
Authors: Semashchenko K. S. , Mongush T. S. , Kosinova A. A. , Subbotina T. N. , Grinshtein Y. I. 
Published: July 2022

Aim. To study the association of nucleotide polymorphisms in platelet receptor and cytochrome P450 genes with the development of resistance to antiplatelet drugs in CHD patients.Material and Methods. The study included 243 patients diagnosed with CHD after coronary artery bypass surgery (CABG), including 140 patients in the acetylsalicylic acid (ASA) treatment group and 103 patients in the dual antiplatelet therapy (DAT) group. All patients were tested for platelet aggregation using an optical aggregometer with inducers: 5 mM ADP and 1 mM arachidonic acid (AA). DNA samples were analyzed by allele-specific PCR for the presence of polymorphisms rs2046934, rs1126643, rs5918, rs6065, rs4244285 in the platelet receptor and cytochrome P450 genes.Results. No statistically significant differences were found during comparison of the prevalence of the studied polymorphisms in the platelet receptor and cytochrome P450 genes between the groups of aspirin-sensitive and aspirin-resistant patients, as well as between the groups of clopidogrelsensitive and clopidogrel-resistant patients. No association between carriage of the minor and major alleles of the polymorphisms studied and the development of antiplatelet drug resistance was found. In the group of patients on ASA therapy, carriers of the C allele of the T1565C (rs5918) ITGB3 polymorphism had a higher rate of AA-induced platelet aggregation compared to carriers of the T allele (18,49±25,92 vs 10,43±17,34, р=0,004).Conclusion. Polymorphisms of P2RY12 (rs2046934), ITGA2 (rs1126643), ITGB3 (rs5918), GP1BA (rs6065), CYP2C19*2 (rs4244285) genes are not associated with antiplatelet drug resistance in both patients on ASC therapy and on DAT. The presence of minor alleles of the rs2046934, rs1126643, rs6065, rs4244285 polymorphisms are not associated with increased platelet aggregation activity before CABG.However, in the group of patients on ASA therapy C-allele carriers of the rs5918 polymorphism of the ITGB3 gene had a higher rate of AA-induced platelet aggregation compared to T-allele carriers.
ANN AND FA Based Wearable Hybrid Fractal Antenna Using Split Rings for Wireless Applications
Authors: S Sandeep Singh , Sivia Jagtar Singh 
Published: July 2022

Abstract
A distinct, ANN and FA-based Wearable Hybrid Fractal Antenna using Split Rings (WHFASR) is explored in this manuscript. The textile substrate chosen for WHFASR is jean having a dielectric constant of 1.7, thickness 1 mm and dimensions 51 x 51 x 1 mm3. The Meander and Koch curves are merged using a mathematical tool Iterative Function System (IFS) for achieving better performance and miniaturization for the designed antenna. ANN demonstrating gives a promising arrangement, particularly for taking care of different issues that are generally experienced in science and engineering. Using the Firefly algorithm (FA) the feed position of the designed antenna is optimized. For implantation of ANN and FA approaches, a data set of 50 WHFASR is generated by varying the feed position using parametric analysis in HFSS software. The proposed WHFASR exhibits two resonant frequency bands 2.44 and 5.01 GHz and S (1, 1) < -10 dB are observed at these resonant frequencies. The proposed WHFASR is manufactured and experienced using Vector Network Analyzer (VNA) and the simulated and experimental outcomes are compared to observe the reliability of the WHFASR.