bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laboratory validation and clinical performance of a saliva‐based test for monkeypox virus
Authors: Allan‐Blitz Lao‐Tzu , Carragher Kevin , Sukhija‐Cohen Adam , Ritchie Phyllis , Scott Hyman , Li Hong , Klausner Jeffrey D. 
Published: October 2022

AbstractImproved diagnostic tests and accessibility are essential for controlling the outbreak of monkeypox. We describe a saliva‐based polymerase chain reaction (PCR) assay for monkeypox virus, in vitro test performance, and clinical implementation of that assay in Los Angeles, San Francisco, and Palm Springs, CA. Finally, using prespecified search terms, we conducted a systematic rapid review of PubMed and Web of Science online databases of studies reporting the performance of oral pharyngeal or saliva‐based tests for the monkeypox virus. The assay showed in silico inclusivity of 100% for 97 strains of monkeypox virus, with an analytic sensitivity of 250 copies/ml, and 100% agreement compared to known positive and negative specimens. Clinical testing identified 22 cases of monkeypox among 132 individuals (16.7%), of which 16 (72.7%) reported symptoms, 4 (18.2%) without a rash at the time of testing. Of an additional 18 patients with positive lesion tests, 16 (88.9%) had positive saliva tests. Our systematic review identified six studies; 100% of tests on oropharyngeal specimens from 23 patients agreed with the PCR test result of a lesion. Saliva‐based PCR tests are potential tools for case identification, and further evaluation of the performance of such tests is warranted.
Effect of Functional Septorhinoplasty with Concha Bullosa Resection on Sinonasal Symptoms
Authors: Inan Serhat , Gultekin Goknil , Yilmaz Ismail , Buyuklu Adnan Fuat 
Published: October 2022

ObjectiveTo evaluate the impact of functional septorhinoplasty (SRP) with and without concha bullosa resection (CBR) on sinonasal symptoms and nasal obstruction severity using the Nasal Obstruction Symptom Evaluation (NOSE) and Sino‐Nasal Outcome Test‐22 (SNOT‐22) scale.MethodsConsecutive adult participants who underwent SRP were retrospectively analyzed. Patients were divided into two groups: Group 1 (SRPwCB) underwent SRP with CBR (bulbous or extensive type MTs), and Group 2 (SRPO) underwent SRP only (normal or lamellar‐type MTs). The NOSE and SNOT‐22 scales were assessed preoperatively and at the 3‐month follow‐up evaluation. Patient demographics, self‐reported outcomes, nasoseptal angle (NSA), and Lund‐Mackay scores (LMS) were analyzed.ResultsThere were 119 participants (SRPwCB n = 57; SPRO n = 62). There were no statistically significant differences in age, sex, allergy, smoking, LMS, and NSA according to the presence of MTCB. Compared to SRPO, SRPwCB patients had significantly higher preoperative NOSE and SNOT‐22 scores, whereas their postoperative NOSE and SNOT‐22 scores were similar. SRPwCB patients also had significantly more postnasal discharge, ear fullness, facial pain/pressure, poor sleep, night waking, daytime fatigue, sense of taste/smell, and blockage symptoms before surgery compared with SRPO patients.ConclusionSRPwCB patients had higher nasal obstruction and sinonasal symptom scores and greater improvement after surgery than SRPO patients. Therefore, evaluating the middle turbinate before functional SRP may be an important for surgical treatment of sinonasal symptoms.Level of Evidence3 Laryngoscope, 133:1375–1381, 2023
Slippery or sticky nano‐porous silica coatings impregnated with squalane: The role of oil over‐layer
Authors: Ubuo Emmanuel E. , Paunov Vesselin N. , Horozov Tommy S. 
Published: October 2022

AbstractSurface designs and wetting mechanisms of Nepenthes pitcher plant provide useful guiding principles for achieving control over the wettability of solid surfaces as mimicked in slippery liquid‐infused porous surfaces (SLIPS). Here, the effect of the over‐layer thicknesses was investigated by gradual impregnation of porous silica coatings with squalane. Characterisation and wettability of the coatings at various stages of the impregnation were studied using fluorescence microscopy, gravimetric analysis and water contact/sliding angle measurements. The technique allowed us to progressively generate variable thicknesses of the oil over‐layers and systematically tune the wetting behaviour of the coatings. The results clarify that very thin oil over‐layer may not lead to slippery surface and the slipperiness of the coated surfaces was observed to increase with increase in the thickness of the over‐layer. It is suggested that fabricated SLIPSs be accompanied with specified workable thickness of the oil over‐layer in order to clearly evaluate their efficiencies.
Utility of high‐resolution ultrasound in measuring subcutaneous fat thickness
Authors: Anvery Noor , Wan Hoi Ting , Dirr McKenzie A. , Christensen Rachel E. , Weil Alexandra , Raja Sabina , Reynolds Kelly A. , Kyllo Rachel L. , Makin Inder Raj S. , Poon Emily , Alam Murad 
Published: October 2022

AbstractObjectivePrevious studies conclude that high‐resolution ultrasound (HRUS) enables noninvasive and accurate measurements of subcutaneous fat thickness. The primary objective of this cross‐sectional study was to better characterize subcutaneous fat thickness measurements in a diverse patient population using HRUS. Secondarily, we sought to correlate these measurements with patients' body image.MethodsA cross‐sectional study to measure subcutaneous fat measurements at seven distinct anatomic sites, including upper and lower extremities, submental, and torso regions, in 40 men and women of different ages and races using HRUS. Independent t‐tests and analysis of variance were performed to analyze findings.ResultsIn our patient population, on average, women had thicker subcutaneous fat than men at all anatomic sites. Asian patients had significantly reduced fat thickness at peripheral anatomic sites, such as arms when compared to patients who identified as Black and Other (p = 0.05 and p = 0.008, respectively). Lastly, women reported decreased total body satisfaction at all anatomic sites when compared to men.ConclusionThe information obtained and methods developed in this study may be utilized clinically during patient selection for fat reduction procedures, including for estimating the degree of likely benefit; for managing pathologies involving subcutaneous fat thickness alteration; and to monitor the progression of lipodystrophy secondary to disease or drugs.
A randomized split‐face comparative study of long‐pulsed alexandrite plus low‐fluence Nd:YAG laser versus pulsed‐dye laser in the treatment of rosacea
Authors: Park Sujin , Lee Joo Hee , Kang Eunji , Kim Hyun , Kim Ji Young , Lee Eun Jung , Bae Yu Jeong , Kim Jihee , Oh Sang Ho 
Published: October 2022

AbstractObjectivesTo compare the effectiveness of long‐pulsed alexandrite laser (LPAL) with that of pulsed‐dye laser (PDL) for rosacea.MethodsThis was a single‐blind randomized controlled trial on 27 patients who were clinically diagnosed with rosacea. Randomly assigned split face in each patient received four times monthly treatment of LPAL plus low‐fluence Nd:YAG with the contralateral side serving as the control treated with PDL. At every visit, the erythema index (EI) was measured with skin analysis systems, and two independent dermatologists evaluated digital photographs for five‐point global aesthetic improvement scale (GAIS).ResultsThe EI significantly decreased on both treated sides (LPAL 366.5 ± 101.0 vs. 295.8 ± 90.2, p < 0.001, PDL 369.0 ± 124.3 vs. 302.7 ± 92.1, p < 0.001) 1 month after fourth treatment (visit 5). Also 3 months after the fourth treatment (visit 6), the reduction in the EI was well maintained on both sides (LPAL 360.3 ± 96.8 vs. 282.0 ± 89.2, p < 0.001, PDL 364.3 ± 121.6 vs. 281.6 ± 97.8, p < 0.001). When comparing the improvement in the EI between the two groups, the percentage reduction in the EI on the LPAL‐treated side was not inferior to the PDL‐treated side (visit 5: LPAL 18.7 ± 15.7% vs. PDL 16.4 ± 12.9%, p = 0.501 and visit 6: LPAL 21.7 ± 13.9% vs. PDL 21.9 ± 15.2%, p = 0.943). The GAIS and patient satisfaction were comparable between the LPAL and PDL sides and did not show any significant difference. No serious adverse events occurred on either of the treated sides.ConclusionThis study showed that the decrease in EI in the treatment of rosacea was comparable between PDL and LPAL. Therefore, LPAL could be a promising alternative treatment option with good merits for rosacea, considering no consumables are required for device maintenance.
Combination of monopolar 2 MHz radiofrequency and electrical multidirectional stimulation for reducing abdominal circumference and enhancing the muscle definition in subjects with overweight range body mass index
Authors: Manuskiatti Woraphong , Nanchaipruek Yanisorn , Gervasio Mia Katrina , Lektrakul Nittaya , Apinuntham Chalermkwan 
Published: October 2022

AbstractBackgroundThe popularity of noninvasive body contouring procedures has been steadily increasing in recent years, however, studies evaluating its effectiveness in individuals with overweight range body mass index (BMI) are limited.ObjectiveTo evaluate the efficacy and safety of combined 2 MHz radiofrequency (RF) and electrical multidirectional stimulation (EMDS) for the improvement of the abdominal contour in subjects with overweight range BMI.MethodsTwelve participants with overweight range BMI (23.6–24.9 kg/m2) underwent a single RF treatment, followed by a series of six EMDS treatments. Follow‐up assessments (abdominal circumference [AC] and skinfold thickness measurements) were scheduled 1, 2, and 3 months after the final session.ResultsAt 1 month after the final treatment, a 3.1% (2.6 ± 0.47 cm, mean ± SD) significant reduction in mean AC was observed (p ˂ 0.001) and a maximal skinfold thickness reduction of 14% (4.6 ± 1.1 mm) was also noted (p = 0.032). Transient dysesthesia lasting 2–3 hours after EMDS treatment was the most common adverse effect reported by 5 of 12 subjects (41.7%), with no other serious side effects.ConclusionsCombined RF and EMDS treatments are safe and effective, yielding significant reductions in both AC and skinfold thickness in patients with overweight range BMI, causing only minimal and transient adverse effects.
A long‐term follow‐up of early breast cancer patients treated with photobiomodulation during conventional fractionation radiotherapy in the prevention of acute radiation dermatitis
Authors: Robijns Jolien , Lodewijckx Joy , Claes Marithé , Lenaerts Melissa , Van Bever Leen , Claes Stefan , Pannekoeke Luc , Verboven Katleen , Noé Leen , Maes Annelies , Bulens Paul , Mebis Jeroen 
Published: October 2022

AbstractObjectivesThe evidence demonstrating the efficacy of photobiomodulation (PBM) therapy for preventing and managing acute radiation dermatitis (ARD) is growing steadily. The question that arises from many clinicians is, if PBM is safe for oncologic patients. This study aimed to evaluate the disease‐free survival (DFS), cancer‐free survival (CFS), and overall survival (OS) of breast cancer patients treated with PBM for ARD.MethodsClinical data of 120 breast cancer patients treated with prophylactic PBM (n = 60, 2x/week, 808−905 nm, 4 J/cm2) or placebo (n = 60) during conventional fractionation (CF) radiotherapy (RT) between April 2015 and June 2017 were retrospectively analyzed (TRANSDERMIS trial). During follow‐up (April 2015 to May 2022), patients underwent a complete clinical evaluation every 6 months and blood analysis and mammography yearly in the first 5 years after the end of RT. The DFS, CFS, and OS were estimated.ResultsAt a median follow‐up time of 66 months (range 4−81), there was no significant difference in DFS (73.7% vs. 98.3%, resp., p = 0.54), CFS (68.4% vs. 77.8%, resp., p = 0.79), and OS (87.9% vs. 98.3%, resp., p = 0.30) between the placebo and PBM group.ConclusionsThis paper is the first to describe the results of a long‐term follow‐up in early‐stage breast cancer patients who underwent PBM for ARD. Results suggest that using PBM in breast cancer patients undergoing CF RT does not influence the locoregional recurrence, the development of new primary tumors, or OS.
State‐owned equity participation and private sector enterprises' strategic risk taking: Evidence from China
Authors: Li Xin , Xu Qiong , Guo Fei , Wang Hecheng 
Published: October 2022

AbstractWhether state‐owned equity participation in private enterprises to implement mixed ownership reform can help the sustainable development of private enterprises has been a widespread topic in recent years. Using data from China's A‐share private listed enterprises from 2014 to 2020, this paper adopts the fixed effect model to examine the impact of state‐owned equity participation on the strategic risk taking of private enterprises. The study finds that state‐owned equity participation can improve private enterprises' strategic risk taking, while alleviating financing constraints and improving corporate governance are important mechanisms. Heterogeneity analysis demonstrates that when enterprises belong to high‐tech enterprises and the industry competition is relatively high, state‐owned equity participation has a more remarkable effect in promoting strategic risk taking of private enterprises. Further research also finds that state‐owned equity participation can improve enterprises' innovation capability, which is embodied in the increase of patent output. This research enriches the relevant achievements of the mixed ownership reform of private enterprises and has certain theoretical and practical guidance for private enterprises' strategic choice.
Radio‐luminescent imaging for rapid, high‐resolution eye plaque loading verification
Authors: Yan Huagang , De Jean Paul , Grafil Elliot , Ashraf Ramish , Niedermayr Thomas , Astrahan Melvin , Mruthyunjaya Prithvi , Beadle Beth , Xing Lei , Liu Wu 
Published: October 2022

AbstractBackgroundEye plaque brachytherapy is currently an optimal therapy for intraocular cancers. Due to the lack of an effective and practical technique to measure the seed radioactivity distribution, current quality assurance (QA) practice according to the American Association of Physicists in Medicine TG129 only stipulates that the plaque assembly be visually inspected. Consequently, uniform seed activity is routinely adopted to avoid possible loading mistakes of differential seed loading. However, modulated dose delivery, which represents a general trend in radiotherapy to provide more personalized treatment for a given tumor and patient, requires differential activities in the loaded seeds.PurposeIn this study, a fast and low‐cost radio‐luminescent imaging and dose calculating system to verify the seed activity distribution for differential loading was developed.MethodsA proof‐of‐concept system consisting of a thin scintillator sheet coupled to a camera/lens system was constructed. A seed‐loaded plaque can be placed directly on the scintillator surface with the radioactive seeds facing the scintillator. The camera system collects the radioluminescent signal generated by the scintillator on its opposite side. The predicted dose distribution in the scintillator's sensitive layer was calculated using a Monte Carlo simulation with the planned plaque loading pattern of I‐125 seeds. Quantitative comparisons of the distribution of relative measured signal intensity and that of the relative predicted dose in the sensitive layer were performed by gamma analysis, similar to intensity‐modulated radiation therapy QA.ResultsData analyses showed high gamma (3%/0.3 mm, global, 20% threshold) passing rates for correct seed loadings and low passing rates with distinguished high gamma value area for incorrect loadings, indicating that possible errors may be detected. The measurement and analysis only required a few extra minutes, significantly shorter than the time to assay the extra verification seeds the physicist already must perform as recommended by TG129.ConclusionsRadio‐luminescent QA can be used to facilitate and assure the implementation of intensity‐modulated, customized plaque loading.
Nominal geometry and force measures for solids and fluids
Authors: Shabana Ahmed A. 
Published: October 2022

AbstractUnderstanding solid‐ and fluid‐inertia forces and their coupling with the gravity potential in complex motion scenarios is necessary for evaluating system stability and identifying root causes of system failure and accidents. Because solids and fluids have an infinite number of degrees of freedom and distributed inertia and elasticity, having meaningful qualitative and quantitative nominal measures of the kinematics and forces will contribute to a better understanding of the system dynamics. This paper proposes developing new continuum‐based nominal measures for the characterization of the oscillations and forces. By using a material‐point approach, these new nominal measures, which have their roots in the continuum‐mechanics partial‐differential equations of equilibrium and Frenet geometry, are independent of the formulation or generalized coordinates used to develop the dynamic equations of motion. The paper proposes a data‐driven‐science approach to define a nominal continuum space‐curve geometry with nominal curvature and torsion; a nominal instantaneous motion plane (IMP), which contains the resultant of all forces including the inertia forces; and a nominal instantaneous zero‐force axis (IZFA) along which the resultant of all forces vanishes. While using the material‐point approach eliminates the need for introducing moment equations associated with orientation coordinates, the IMP and IZFA concepts can be used to define the instantaneous axis of significant moment components, which can lead to accidents such as in the case of vehicle rollovers.
Long‐term device survival after a first implantation of AMS800™ for stress urinary incontinence: Comparison between men and women
Authors: Cotte Juliette , Dechartres Agnès , Mozer Pierre , Poinard Florence , Chartier‐Kastler Emmanuel , Beaugerie Aurélien 
Published: October 2022

AbstractPurposeThe artificial urinary sphincter is the reference treatment for stress urinary incontinence in men, but it remains rarely used in women. This study aimed to compare long‐term device survival between women and men, after the first implantation of an AMS800™ artificial urinary sphincter (Boston Scientific) for the treatment of a non‐neurogenic stress urinary incontinence.Materials and MethodsThis retrospective cohort study included all patients with nonneurogenic stress urinary incontinence who underwent surgery in a large‐volume university hospital between 2000 and 2013. The primary outcome was the overall survival of the device, defined as the absence of any repeated surgery (revision or explantation) during follow‐up. Men and women were matched 3:1 according to age and year of implantation. Differences were analyzed using a Cox model accounting for matching and applying time intervals because hazards were not proportional over time. Sensitivity analyzes were performed, excluding firstly a population with a history of radiotherapy and secondly a population with more than one previous surgery for urinary incontinence.ResultsA total of 107 women were matched to 316 men. Median follow‐up was 6.0 years (Q1–Q3 1.8–9.4): 7.0 years (Q1–Q3 3.1–10.3) for women and 5.1 years (Q1–Q3 1.3–9.1) for men. During the follow‐up, 56 patients had an explantation of the device: 44 men (13.9%) and 12 women (11.2%), and 113 had a revision: 85 men (26.9%) and 28 women (26.1%). Men have a significantly higher risk of explantation or revision than women between 6 months and 8 years after implantation (hazard ratio 2.12 [1.29–3.48]). Before 6 months and after 8 years, there were no significant differences. Both sensitivity analyses found consistent results.ConclusionsThis study suggests that device survival seems better in women after the first 6 months.
Nurses' role in the management of persons with chronic urogenital pelvic pain syndromes: A scoping review
Authors: Terzoni Stefano , Ferrara Paolo , Parozzi Mauro , Colombani Federica , Mora Cristina , Cilluffo Silvia , Jeannette Verkerk Geelhoed , Destrebecq Anne , Pinna Barbara , Lusignani Maura , Chiara Sighinolfi , Giorgia Gaia , Rocco Bernardo 
Published: October 2022

AbstractBackgroundPelvic pain has cognitive, behavioral, sexual, and emotional consequences. Nurses involved in pelvic floor rehabilitation clinics have contacts with patients reporting chronic pain and should know the most appropriate service for patient referral, to submit the problem to professionals capable of correctly assessing and managing the condition. Furthermore, in some countries nurses can use conservative methods to treat the painful symptoms inside a multidisciplinary team such as breathing retraining, biofeedback, and noninvasive neuromodulation. This paper aims to provide an overview of the literature regarding the role of rehabilitation nurses in dealing with patients suffering from chronic urogenital pelvic pain or urogenital painful syndromes, inside a multidisciplinary team.MethodsScoping review on Pubmed, CINAHL, Embase, Scopus, Web of Science including trials, reviews, case studies or series, and other descriptive studies regarding the role of nurses inside the multidisciplinary team in the management of males and females presenting chronic pelvic pain (CPP) or chronic pelvic pain syndrome (CPPS).ResultsThe 36 papers included in this review allowed answering research questions in four areas of nursing: collecting basic information, referring the person to appropriate services, evidence‐based nursing interventions for CPP and CPPS, and proper documentation. Clinical history and assessment of breathing pattern, Muscular assessment and research of trigger points are the main points of data collection. Techniques for muscular relaxation and breathing retraining are important aspects of treatment, as well as biofeedback and noninvasive neuromodulation where the law allows nurses to practice such techniques. The McGill pain questionnaire and the pain inventory of the International Pain Society allow systematic data collection and handover.ConclusionRehabilitation nurses work inside multidisciplinary teams when dealing with persons suffering from pelvic pain; further research is needed as our comprehension of the underlying pathophysiological mechanisms of CPP and CPPS evolve.