bluuebunny/crossref_metadata_2025_split huggingface dataset:
Societal preferences for funding orphan drugs in China: An application of the discrete choice experiment method
Authors: Tan Shuoyuan , Wang Yu , Tang Yuqing , Jiang Rong , Chen Mingsheng , Chen Haihong , Yang Fan 
Published: December 2022

ObjectivesTo explore whether a societal preference for orphan drugs exists in Chinese general public and to quantitatively measure the personal trade-off between essential attributes of orphan drugs through a discrete choice experiment.MethodsA labeled discrete choice experiment was employed to measure public preference. Six attributes (impact of diseases on life-years, impact of diseases on quality of life, availability of alternative drug treatments, annual cost per patient paid by medical insurance, expected increases in life-expectancy, and improvements to the quality of life) were identified through a literature review, experts' suggestions, and stakeholders' semi-structured interviews, then refined through a pre-survey. The current study used a D-efficient design to yield 27 choice sets divided into three blocks with nine questions containing the labeled treatment (either orphan drugs or common drugs). Information on sociodemographic characteristics and individual preferences was collected through a web-based questionnaire using convenience sampling. A mixed logit model was used to test societal preferences for orphan drugs over common drugs, while a binary logit model was used to measure the relative importance of each attribute in orphan drug access for the National Reimbursement Drug List and its willingness to pay.ResultsA total of 323 persons participated in this study. Respondents largely had indifferent attitudes toward orphan drugs and common drugs. The binary logit model results showed that 5 of the 6 attributes were significant, except for the availability of alternative drug treatments. The most impacted factor was the annual cost per patient paid by medical insurance (β = −1.734, odds ratio [OR] = 0.177). Among non-economic attributes, the impact of diseases on life-years—with no treatment, the patient will die in the prime of life (β = 0.523, OR = 1.688, willingness to pay = 301,895)—was most concerning, followed by significant improvements to the quality of life (β = 0.516, OR = 1.676, willingness to pay = 297,773).ConclusionThe general public in China does not value rarity as a sufficient reason to justify special consideration in funding orphan drugs. When making orphan drug coverage decisions, the public prioritized the annual cost, disease severity, and drug effects.
Driving the effectiveness of public health emergency management strategies through cross-departmental collaboration: Configuration analysis based on 15 cities in China
Authors: Wang Hongmei , Sun Jing , Shi Yinfeng , Shen Tingyue 
Published: December 2022

BackgroundOwing to the complexity of and changes associated with modern public health emergencies, cross-departmental collaborative governance is an inevitable choice for ensuring effective emergency management. In the context of emergency management research, the way in which taking full advantage of synergy can be used to enhance the effectiveness of emergency prevention and control approaches is an important issue that must be addressed urgently.MethodsCombined with China's responses to the management of public health emergencies, in this study, we construct a theoretical analysis framework involving three dimensions: information, organization, and environment. Our proposed framework relies on the fuzzy-set qualitative comparative analysis (fsQCA) method to analyze the mechanisms behind the prevention and control of coronavirus disease 2019 (COVID-19) cases across 15 cities located in typical provinces throughout China and explore the roles of cross-departmental collaboration in the processing of various elements as well as the effects of their combination on the action mechanisms for ensuring the effectiveness of emergency management approaches.FindingsThe results show a significant conditional correlation between the effectiveness of emergency management and the factors affecting cross-departmental coordination. Based on the characteristics of multiple concurrent paths, the driving paths can be classified into four categories: organizational, environmental, environment-balanced, and organization environment-based dual-core categories.ConclusionsThe effectiveness of public health emergency management is the result of multiple factors. Local governments should strengthen the coordination and integration of information, organization, and environment, improve the coordinated system associated with emergency management, promote the “two-wheel drive” of high-quality development as well as accurate prevention and control, explore and perfect the adaptive combinatorial optimization path, and effectively transform the advantages of linking multi-dimensional factors with governance efficiency.
Relationship between occupational noise exposure and hypertension: Cross-sectional evidence from real-world
Authors: Zhang Ling , Chen Siqi , Chen Zhuowang , Yin Wenjun , Fu Wenjuan , He Fang , Pan Zhen , Yi Guilin , Tan Xiaodong 
Published: December 2022

BackgroundOccupational noise is one of the most common and prevalent occupational hazards worldwide and may induce adverse auditory and/or non-auditory health effects. However, the relationship between occupational noise exposure and hypertension is controversial and has long been debated.MethodsBased on large sample cross-sectional data from all registered occupational health examination units from 2021 to 2022 (N = 101,605), this study aimed to analyze the prevalence of hearing loss and hypertension and to explore the influencing factors of hypertension of workers in Wuhan. Descriptive statistics, univariate analyses and multivariate analyses were used. Forest plot and nomograms were constructed for the visualization of predictive results. The ROC curve, AUC, C-index and calibration curves were used to assess the predictive accuracy and validity. DCA was performed to evaluate the net benefit that workers could receive.ResultsHigher rate of high-frequency hearing loss (25.3%), speech frequency hearing loss (8.8%), ECG abnormalities (31.9%) and hypertension (21.0%) were found in workers exposed to occupational noise in Wuhan. Occupational noise exposure (OR = 1.09, 95% CI: 1.01–1.18, p = 0.04), growth of age (OR: 1.07, 95% CI: 1.07–1.07, p &lt; 0.001), overweight (OR: 1.82, 95% CI: 1.73–1.92, p &lt; 0.001), obesity (OR: 3.62, 95% CI: 3.42–3.83, p &lt; 0.001), hyperglycemia (OR: 1.84, 95% CI: 1.73–1.96, p &lt; 0.001), hypercholesterolemia (OR = 1.34; 95% CI 1.22–1.48; p &lt; 0.001), ECG abnormalities (OR = 1.11; 95% CI 1.07–1.15; p &lt; 0.001) and family history of hypertension (OR = 1.69; 95% CI 1.58–1.81; p &lt; 0.001) were risk factors of hypertension for workers. Male workers had a relatively higher hypertension risk than female workers (OR = 1.61; 95% CI 1.54–1.69; p &lt; 0.001). Ear protective measures could not reduce the risk of hypertension in workers. Our nomogram has good predictive accuracy and validity. A dynamic nomogram to predict the workers' risk of hypertension was established publicly available online.ConclusionOccupational noise exposure may elevate workers' hypertension risk. More effective and relevant prevention measures should be taken. Our nomogram may help identify high-risk workers and facilitate timely interventions.
Latin Matchings and Ordered Designs OD(n−1, n, 2n−1)
Authors: Jin Kai , Zhu Taikun , Gu Zhaoquan , Sun Xiaoming 
Published: December 2022

This paper revisits a combinatorial structure called the large set of ordered design (LOD). Among others, we introduce a novel structure called Latin matching and prove that a Latin matching of order n leads to an LOD(n−1, n, 2n−1); thus, we obtain constructions for LOD(1, 2, 3), LOD(2, 3, 5), and LOD(4, 5, 9). Moreover, we show that constructing a Latin matching of order n is at least as hard as constructing a Steiner system S(n−2, n−1, 2n−2); therefore, the order of a Latin matching must be prime. We also show some applications in multiagent systems.
PENGARUH AKUNTABILITAS DAN KETERBUKAAN INFORMASI TERHADAP KINERJA PELAYANAN PEMERINTAH DAERAH (Survei pada Desa diKecamatan Parongpong Kabupaten Bandung Barat)
Authors: Puspitawati Lilis , Marsellina Bella Silvia 
Published: December 2022

Penelitian ini bertujuan untuk mengetahui besar pengaruh Akuntabilitas Dan Keterbukaan Informasi, Terhadap Kinerja Pelayanan pemerintahan daerah pada Satuan Kerja Perangkat Desa (SKPDes) untuk masing-masing desa di Kecamatan Parongpong. Metode analisis yang digunakan dalam penelitian ini adalah metode analisis deskriptif dan verifikatif dengan menggunakan pendekatan kuantitatif. Populasi dalam penelitian ini yaitu desa di kecamatan parongpong kabupaten bandung barat.Teknik pengambilan sampel dalam penelitian ini menggunakan teknik Probability Sampling dan untuk memperoleh data menggunakan metode Simpel Random Sampling sehingga diperoleh 35 orang responden pada penelitian ini, Sumber data dalam penelitian ini adalah data primer yang diperoleh dari jawaban kuesioner responden. Pengujian statistik yang digunakan untuk menguji hipotesis adalah analisis regresi linear berganda dengan menggunakan alat analisis software SPSS Versi 26.0.Hasil pengujian hipotesis dalam penelitian menunjukkan bahwa Akuntabilitas berpengaruh positif terhadap Kinerja pelayanan pemerintahan daerah, dan Transparansi berpengaruh positif terhadap Kinerja pelayanan pemerintahan daerah.
COMPARATIVE ANALYSIS OF THE EFFECTIVENESS AND EFFICIENCY OF ENVIRONMENTAL COST CONTROL IN REALIZING THE ECO-EFFICIENCY OF MINING COMPANIES
Authors: Amaliya Fathiyya Fitri , Burhany Dian Imanina 
Published: December 2022

Mining companies are required to show greater environmental care and responsibility. Environmental cost classification and reporting can help achieve the effectiveness and efficiency of environmental cost control. This study aims to determine and compare the effectiveness and efficiency of environmental cost control of mining companies, determine the company's eco-efficiency, and determine its effect on eco-efficiency. This comparative descriptive research and quantitative research uses secondary data, namely data on environmental costs and financial data of PT TIMAH Tbk. (TIMAH) and PT Aneka Tambang Tbk. (ANTAM) for 2016-2020 which collected through documentation. Data were analyzed using ratio analysis, trend, and simple linear regression. The results of the study found that: (1) TIMAH and ANTAM have not adopted environmental cost reporting based on the theory of Hansen et al., (2) Environmental cost control ANTAM more effective than TIMAH, (3) Environmental cost control TIMAH more efficient than ANTAM, (4) The highest eco-efficiency of TIMAH obtained in 2016, while the highest eco-efficiency of ANTAM obtained in 2018, (5) The effectiveness of environmental cost control has a significant effect on eco-efficiency. However, the efficiency of controlling environmental costs has no significant effect on eco-efficiency.

Keywords: Effectiveness and Efficiency, Environmental Cost, Eco-efficiency
ETIKA DAN KINERJA MAHASISWA
Authors: Octavia Evi , Tresnawati Rina , Verdania Dini 
Published: December 2022

Penelitian ini dilakukan untuk mengetahui dan menguji pengaruh antara etika dan kinerja mahasiswa. Penelitian ini menggunakan data primer melalui questioner dengan menggunakan metode kuantitatif. Responden adalah mahasiswa akuntansi yang mengambil mata kuliah akuntansi manajemen pada Universitas Widyatama. Adapun analisis data yang digunakan adalah analisis regresi linear sderhana dan diolah dengan menggunakan aplikasi SPSS 20 dengan menetapkan tingkat signifikansi 0,05 untuk pengujian hipotesisnya. Hasil Penelitian menunjukan terdapat pengaruh variabel penerapan etika (X1) dan kinerja mahasiswa (Y) pada Mahasiswa Akuntansi Universitas Widyatama, yaitu sebesar 0,731.

Kata kunci: Etika, kinerja mahasiswa, Dosen
WHAT CAN FINANCIAL PERFORMANCE BE INFLUENCED BY THE INTENSITY OF GREEN BIOLOGICAL AND ACCOUNTING ASSETS
Authors: Lisnawati Lisna 
Published: December 2022

Abstract
This study aims to examine the effect of biological asset intensity and green accounting on Financial Performance. Quantitative research method with Multiple Linear Regression model is used as an analytical tool. Samples were taken using a purposive sampling technique as many as 90 years of agricultural companies. The results empirically prove that Biological Asset Intensity has no effect on Financial Performance in agricultural companies, Green Accounting has an influence on financial performance of agricultural companies, there is no relationship between Biological Asset Intensity and Green Accounting, and Biological Asset Intensity and Green Accounting together have an influence on the Financial Performance of agricultural companies listed on the IDX in 2017-2019.
Avaliação do índice de resto-ingestão e sobras de uma unidade de alimentação e nutrição
Authors: Maia Silvana Mara Prado Cysne , Moreira Marta da Rocha , Diniz Jessica Pereira de Oliveira , Lopes Bianca Castelo Palmeira , De Souza Geisa Oliveira Fernandes , Barbosa Suzane da Silva 
Published: December 2022

A quantidade de resíduos orgânicos produzidos pelas Unidades de Alimentação e Nutrição (UANs) refletem o desperdício de alimentos que poderiam ser aproveitados. As sobras e o resto ingestão gerados constitui um parâmetro para se determinar a qualidade do serviço e sua falta de integração com seus comensais, além de ser um indicador para a redução dos custos. O trabalho teve como objetivo avaliar as sobras e os resto ingestão produzidos no horário do almoço, das 11:00hs até 13:30hs de uma UAN de Fortaleza, CE. Os resultados mostraram um grande desperdício, onde aproximadamente 453 pessoas poderiam ser alimentadas com os restos e sobras acumuladas durante os oito dias da coleta de dados. Uma média de 37,9kg por dia foram desprezados, refletindo um alto índice de desperdício tanto do cliente quanto ao mau planejamento da UAN. Conclui-se que apesar do índice do resto ingestão se encontrar aceitável, a quantidade desprezada ainda é excessiva. O uso de medidas de redução das perdas, a otimização da alimentação, a orientação e conscientização dos envolvidos e um planejamento da equipe são algumas medidas corretivas que podem ser implantadas que visam a redução de lixos e custos desnecessários.
Terapia gênica no avanço do tratamento da ataxia espinocerebelar
Authors: De Souza Raquel Araújo , Silva Lucas Luiz de Lima , Marques Juliana Menara de Souza , Camplesi Daniela Cristina Fonseca , Passos Xisto Sena , Camplesi Junior Milton 
Published: December 2022

Objetivo-. Este trabalho teve como objetivo apresentar os avanços da terapia gênica na ataxia cerebelar, com ênfase na área espinocerebelar. Métodos - Foram coletadas informações de artigos originais, publicados em revistas, nos idiomas, inglês, português e espanhol, as bases de busca foram a Biblioteca Virtual em Saúde (BVS), Scientific Electronic Library Online (SciELO), Google Acadêmico e no site do National Center for Biotechnology Information (NCBI), com prioridade de artigos dos últimos dez anos. Resultados- Foi demonstrado que o modelo de tratamento de ataxias espinocerebelares por meio de vírus associados a adeno (AAV) junto a um RNA é uma técnica com potencial, capaz de retardar e reverter os sintomas da doença, porém ainda não se tem comprovação de segurança, devido ao pouco conhecimento sobre o assunto(excluir pois não podemos desmerecer a técnica). Conclusão – Como abordado nesse trabalho, A terapia gênica tem se mostrado a forma mais adequada de tratamento de ataxias espinocerebelares que causam poliglutaminas, por este fato se faz necessário mais pesquisas a respeito.
Utilização do método de ensino TBL (team based learning) como alternativa para consolidação de conteúdos da cardiologia
Authors: Cavalcante Aires Gabriel Ferro , Alves Alysson Yuri dos Santos , Galindo Bernardo de Almeida , Neres Kanandra Hawana Scartezini 
Published: December 2022

Comumente encontramos estudantes que adotam uma postura passiva, com pouca participação em discussões sobre o conteúdo. A esse cenário estão associados os métodos de ensino tradicional, caracterizado por aulas expositivas. Nesse contexto, surgiram metodologias que buscam consolidar o saber. O TBL (Team Based Learning), é um elemento motivacional para o estudo, uma vez que exige a aplicação dos conhecimentos adquiridos individualmente.
Keberhasilan Agribisnis Ubi Jalar (Ipomoea batatas, Poir) (Suatu Kasus Pada Usahatani Ubi Jalar di Kecamatan Pamulihan, Kabupaten Sumedang, Jawa Barat)
Authors: Hidayatullah Raden Mohammad , Dasipah Euis , KS Karyana 
Published: December 2022

The research has purpose to know the success of Â sweet potatoesÂ farming and the faktors influenced.Â The research method wasÂ used by survey technique to the farmers in Pamulihan Subdistrc, Sumedang Regency,Â West Java.Â The dataÂ taken by sampling technique and carried out 64 unit.Â Â The data wasÂ analyzed byÂ using the path analyze with two ways.Â The researchÂ resultÂ the the farmerâ€™s institution and socio-economic characteristic give effect to Â the adoption of sweet potatoesÂ farm technology.Â The affected of the farmerâ€™s institution shown higher than socio-economic characteristic. And also the institution of the farmerâ€™s and socio-economic characteristic had an effect to the succsess of Â sweet potatoesÂ farming.Â The adoption of technology had the greatest affect than the farmerâ€™s institution and socio-economic characteristic.
Pertumbuhan dan Hasil Tanaman Jagung Manis (Zea Mays L. Sacchata Strut) Akibat Takaran Pupuk Nitrogen dan Zeolit
Authors: Irawan Hendra , Noertjahyani Noertjahyani , Widodo R. Wahyono 
Published: December 2022

Penelitian dilaksanakan untuk mengetahui pertumbuhan dan hasil tanaman jagung manis (Zea mays L. Saccharata sturt) akibat takaran pupuk nitrogen dan zeolit. Rancangan lingkungan yang digunakan dalam percobaan ini yaitu Rancangan Acak Kelompok (RAK) pola faktorial yang terdiri atas dua faktor perlakuan. Faktor pertama adalah takaran nitrogen (N) terdiri atas lima taraf yaitu: 0 kg ha-1 (n0), 75 kg ha-1 (n1), 150 kg ha-1 (n2), 225 kg ha-1 (n3), 300 kg ha-1 (n4). Faktor kedua adalah takaran zeolit (Z), terdiri atas dua taraf yaitu: 0 kg ha-1 (z0) dan 1000 kg ha-1 (z1). Dengan demikian dalam percobaan ini terdapat 10 kombinasi perlakuan. Setiap perlakuan diulang tiga kali, sehingga seluruhnya terdapat 30 satuan unit percobaan. Hasil sidik ragam menunjukkan bahwa tidak terjadinya interaksi anatara pemberian perlakuan nitrogen dan zeolit, disebabkan karena kelarutan nitrogen di dalam tanah masih tinggi dan nitrogen masih dijerap oleh zeolit serta belum bisa di dilepaskan, sehingga nitrogen di dalam tanah belum tersedia bagi tanaman jagung. Sedangkan terjadinya interaksi pada jumlah daun tanaman jagung umur 4 MST, diduga bahwa nitrogen dalam bentuk amonium yang dijerap oleh zeolit telah berubah menjadi hara nitrat yang bisa dimanfaatkan oleh tanaman, sehingga ada korelasi antara jumlah daun dengan ketersediaan hara dalam tanah. Pada taraf zeolit (z1), takaran optimum pupuk nitrogen sebesar 194,3 kg ha-1, dapat menghasilkan bobot tongkol berkelobot 22,33 ton ha-1. Sedangkan pada taraf zeolit (z0), dengan takaran optimum pupuk nitrogen sebesar 215,06 kg ha-1, hanya menghasilkan bobot tongkol berkelobot 18,832 ton ha-1, sehingga semakin tinggi dosis zeolit yang diberikan dapat mengefisiensikan pengunaan pupuk nitrogen.
Pengaruh Jenis Media Dan Konsentrasi Auksin Terhadap Pertumbuhan Akar Setek Tanaman Lada (Piper ningrum L.)
Authors: Listiana Srie Andiani , Budiasih R. , Sondari Nunung 
Published: December 2022

Penelitian bertujuan untuk mempelajari dan mengetahui jenis media dan konsentrasi auksin pada pertumbuhan akar. Penelitian dilaksanakan pada bulan Mei 2020 sampai September 2020 di lahan petani Desa Suriamukti Kecamatan Surian Kabupaten Sumedang Provinsi Jawa Barat. Rancangan percobaan yang digunakan adalah rancangan acak kelompok (RAK) pola faktorial yang terdiri dari 2 faktor yaitu jenis media tanam (m) dan Konsentrasi auksin (r). Masing-masing perlakuan terdiri dari 4 taraf, sehingga diperoleh 16 kombinasi perlakuan dan diulang sebanyak 2 kali. Seluruhnya menjadi 32 satuan percobaan. faktor pertama jenis media tanam (m) yang terdiri dari empat taraf : m0 = tanah, m1 = tanah + pupuk kandang domba, m2 = tanah + pasir, m3 = tanah + pupuk kandang domba + pasir. Faktor kedua adalah konsentrasi auksin (r) yang terdiri dari 4 taraf : r0 = 0 mgL-1, r1 = 100 mgL-1, r2 = 200 mgL-1, r3 = 300 mgL-1. Hasil penelitian menunjukkan terjadi interaksi pada parameter jumlah tunas 12 MST. Akan tetapi tidak terjadi interaksi antara jenis media dan konsentrasi auksin pada parameter, panjang tunas, jumlah daun, dan volume akar. Secara efek mandiri media tanah dan pasir memberikan volume akar yang baik dan sama dengan media tanah + pasir + pupuk kandang.
Pengaruh Jenis Nutrisi dan Jenis Media Tanam terhadap Pertumbuhan dan Hasil Tanaman Pakcoy (Brassica chinensis L.) Varietas Nauli F-1 Secara Hidroponik Sistem Wick
Authors: Desmasari Noviana , Hidayat Odang , Masnenah Endeh 
Published: December 2022

Teknik budidaya hidroponik sebagai upaya intensifikasi, dapat meningkatan efisiensi dan efektivitas peggunaan lahan. Tujuan penelitian ini adalah untuk mempelajari interaksi antara jenis nutrisi dan jenis media tanam terhadap partumbuhan dan hasil tanaman pakcoy (Brassica chinensis L.) Varietas Nauli F-1 secara hidroponik sistem wick. Percobaan dilakukan di Green house Fakultas Kehutanan Universitas Winaya Mukti Sumedang, ketinggian 850 meter di atas permukaan laut, pada bulan Juni hingga Juli 2021. Percobaan menggunakan Rancangan Acak Kelompok (RAK) pola faktorial, terdiri dari dua faktor yaitu faktor pertama jenis nutrisi (n1 = Ab mix 100%, (Kontrol) ; n2 = Ab mix 50% + POC kelinci 50% ; n3 = POC kelinci 100%) dan faktor kedua jenis media tanam (m1 = Rockwool, (Kontrol) ; m2 = Arang sekam; m3 = Cocopeat) serta percobaan di ulang tiga kali. Hasilpercobaan menunjukkan terjadi interaksi antara jenis nutrisi dan jenis media tanam terhadaptinggi tanaman umur 10 HST, 15 HST, 20 HST, 25 HST, 30 HST, jumlah daun umur 10HST, 25 HST, 30 HST dan bobot segar tanaman, sedangkan pada jumlah daun umur 15 HST,20 HST, panjang akar dan luas daun tidak terjadi interaksi. Kombinasi nutrisi Ab mix 100%dan media tanam rockwool memberikan pertumbuhan dan hasil terbaik pada setiap parameter pengamatan.
Keterlibatan Awam dalam Misi Kerasulan di Keuskupan Ketapang Ditinjau dari Perspektif Mgr. Gabriel Wilhelmus Sillekens CP
Authors: Endi Yohanes , Mujianto Agustinus , Watu Christianus 
Published: December 2022

Fokus utama tulisan ini ialah misi pewartaan Injil yang berakar dalam Kristus. Mgr. Sillekens dalam misinya di Keuskupan Ketapang menekankan betapa pentingnya hidup dalam Kristus yang tampak dalam Sakramen Ekaristi, Sakramen Pengampunan dan dalam kesaksian hidup. Kesaksian hidup yang berakar di dalam Kristus itulah yang menjadi dasar dalam merasul di tengah-tengah dunia terutama di dalam keluarga. Dalam karya kerasulan, Gereja membutuhkan terobosan-terobosan baru yang kreatif, inovatif dan hidup. Wajah Allah yang penuh kasih harus tampak dalam wajah keluarga-keluarga kristiani dimanapun mereka berada. Dalam menggarap artikel ini penulis menggunakan pendekatan hermeneutik terhadap beberapa sumber pustaka terutama Surat Gembala dari Mgr. Sillekens dan dokumen-dokumen Gereja untuk mendapatkan informasi yang komprehensif guna memahami misi pewartaan secara lebih mendalam. Beberapa temuan yang penulis masukkan dalam tulisan ini adalah bahwa misi pewartaan Iniil itu harus sungguh-sungguh berasal dari Kristus, mengakar di dalamNya dan bertumbuh di dalamNya. Tanpa Kristus maka misi pewartaan tidak akan pernah berhasil. Langkah-langkah konkrit yang telah dilakukan oleh Mgr. Sillekens menunjukkan bahwa betapa pentingnya berakar dalam Kristus itu untuk sebuah misi pewartaan. Selain itu Gereja harus terus melibatkan kaum awam sebagai bagian krusial dari pertumbuhan Gereja lokal-Keuskupan.