bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diabetic ketoacidosis and coronavirus disease 2019-associated mucormycosis: a case report
Authors: Monroig Vanessa , Tarquinio Keiko M. 
Published: October 2022

Abstract
Background
Mucormycosis is a rare, life-threatening fungal infection that affects immunocompromised hosts. Diabetes mellitus is a common predisposing condition and most often presents with rhino-orbital-cerebral infection. Association with coronavirus disease 2019 infection was revealed following a resurgence in cases of mucormycosis during the second wave of the pandemic wherein poorly controlled diabetes mellitus was the most significant risk factor in the affected population. Rhino-orbital-cerebral mucormycosis has a high mortality rate, and cerebral involvement is a poor prognostic factor. Herein, we report a case of newly diagnosed diabetes mellitus with concurrent coronavirus disease 2019 infection complicated by diabetic ketoacidosis and rhinocerebral mucormycosis at presentation, describe the diagnostic and therapeutic challenges, and discuss the interventions that ultimately resulted in a favorable clinical response.

Case presentation
We describe the case of a previously healthy 13-year-old African American female patient with newly diagnosed diabetes mellitus and concurrent severe acute respiratory syndrome coronavirus 2 infection whose disease course was complicated by rhinocerebral mucormycosis. She presented with fever, altered mental status, and Kussmaul respirations and was diagnosed with diabetic ketoacidosis with concern for cerebral edema. Concern for infectious cerebritis arose due to recurring fevers and persistently altered mental status despite correction of her metabolic derangements. This raised concern for infectious cerebritis and prompted evaluation with serial head imaging, lumbar puncture, and initiation of broad empiric antimicrobial regimen. Head imaging revealed an evolving cerebral abscess, and fungal deoxyribonucleic acid was identified on blood metagenomics testing, which ultimately confirmed the diagnosis of rhinocerebral mucormycosis. Treatment was challenging as she required surgical debridement of the frontal lobe and aggressive antifungal therapy complicated by electrolyte derangements and electrocardiogram changes that necessitated modification of the antimicrobial regimen. Despite these challenges and high mortality rate, the patient was discharged from the hospital in stable condition to inpatient rehabilitation service for reconditioning after prolonged hospitalization.

Conclusion
Rhinocerebral mucormycosis mortality is associated with delays in therapeutic interventions, thus a high index of suspicion and early recognition were essential for timely initiation of antifungal therapy and surgical debridement.
Cave feature extraction and classification from rockery point clouds acquired with handheld laser scanners
Authors: Lou Lizhi , Wei Chaoxu , Wu Hangbin , Yang Chen 
Published: October 2022

Abstract
Rockeries are unique elements of Chinese classical gardens with historical, cultural, artistic, and scientific value. One of the essential characteristics of garden rockery is the cave features since cave morphological features determine the degree of “Tou” (riddled through) and “Lou” (hollowed out well) features as the defined by rockery appreciation theory, which is important for rockery heritage conservation, assessment, and management. However, in heritage studies, accurately identifying and evaluating rockery caves is a difficult task because of a cave's irregular shape. This paper proposes a methodology to extract and classify cave features by point clouds obtained from data using a handheld laser scanner with a camera. Without completing surface reconstruction, the rockery point cloud is first sliced into chips, then cave chips were extracted from these approximately two-dimensional chips and next merged to obtain three-dimensional cave point clouds. Finally, the cave boundary points are extracted from the cave and fitted by an ellipse for classification. To extract and classify cave features, a methodology to improve rockery digitalization quality is also proposed. The raw point cloud data were preprocessed by pose adjustment, noise removal, and hole repair. The experimental results for the two rockeries in Tongji University and Qiuxiapu Garden indicate that the improved digitization scheme generates complete and closed rockery point clouds, all types of caves were effectively extracted and classified by our proposed method. Additionally, the extracted caves are still represented by point clouds, which suggest the possibility for other research in the future.
Implementing the European Society for Medical Oncology Scale for Clinical Actionability of Molecular Targets in a Comprehensive Profiling Program: Impact on Precision Medicine Oncology
Authors: Martin-Romano Patricia , Mezquita Laura , Hollebecque Antoine , Lacroix Ludovic , Rouleau Etienne , Gazzah Anas , Bahleda Rastilav , Planchard David , Varga Andrea , Baldini Capucine , Postel-Vinay Sophie , Friboulet Luc , Loriot Yohann , Verlingue Loic , Geraud Arthur , Camus Maud Ngo , Nicotra Claudio , Soria Jean Charles , André Fabrice , Besse Benjamin , Massard Christophe , Italiano Antoine 
Published: October 2022

PURPOSETo facilitate implementation of precision medicine in clinical management of cancer, the European Society of Medical Oncology proposed in 2018 a new scale to harmonize and standardize the reporting and interpretation of clinically relevant genomics data (ESMO Scale of Actionability of molecular Targets [ESCAT]). This study aims to characterize the clinical impact of matching targetable genomic alterations (GAs) in patients with advanced cancer according to ESCAT.MATERIAL AND METHODSAnalysis of next-generation sequencing results from 552 patients is included in two prospective precision medicine studies at Gustave Roussy. End points included objective response rates, progression-free survival, and overall survival according to ESCAT.RESULTSMolecular data from 516 patients were available and discussed within a Molecular Tumor Board. The most common tumor types were GI (n = 164; 30%), lung (n = 137; 25%), and urologic tumors (n = 68; 13%). Overall, 379 GAs were considered as actionable targets according to ESCAT in 348 (67%) patients. In 31 (6%) patients, two concomitant actionable targets were identified. On the basis of ESCAT, GAs were considered to be classified as tier I in 120 patients (29%), II in 25 patients (5%), III in 80 patients (16%), and IV in 153 patients (30%). A total of 136 patients (27%) received a matched therapy. ESCAT was significantly associated with objective response rates and clinical benefit rates. The median progression-free survival was 6.5 months (95% CI, 4.2 to 8.9), 3 months (95% CI, 1 to not available), 3 months (95% CI, 2.2 to 3.8), and 4 months (95% CI, 2.8 to 6.3) for ESCAT I, II, III, and IV, respectively ( P = .0125).CONCLUSIONImplementation of ESCAT classification for clinical decision making by Molecular Tumor Board is feasible and useful to better tailor therapies in patients with cancer.
The ERM-1 membrane-binding domain directs erm-1 mRNA localization to the plasma membrane in the C. elegans embryo
Authors: Winkenbach Lindsay P. , Parker Dylan M. , Williams Robert T. P. , Nishimura Erin Osborne 
Published: October 2022

ABSTRACT
mRNA localization and transport are integral in regulating gene expression. In Caenorhabditis elegans embryos, the maternally inherited mRNA erm-1 (Ezrin/Radixin/Moesin) becomes concentrated in anterior blastomeres. erm-1 mRNA localizes within those blastomeres to the plasma membrane where the essential ERM-1 protein, a membrane-actin linker, is also found. We demonstrate that the localization of erm-1 mRNA to the plasma membrane is translation dependent and requires its encoded N-terminal, membrane-binding (FERM) domain. By perturbing translation through multiple methods, we found that erm-1 mRNA localization at the plasma membrane persisted only if the nascent peptide remained in complex with the translating mRNA. Indeed, re-coding the erm-1 mRNA coding sequence while preserving the encoded amino acid sequence did not disrupt erm-1 mRNA localization, corroborating that the information directing mRNA localization resides within its membrane-binding protein domain. A single-molecule inexpensive fluorescence in situ hybridization screen of 17 genes encoding similar membrane-binding domains identified three plasma membrane-localized mRNAs in the early embryo. Ten additional transcripts showed potential membrane localization later in development. These findings point to a translation-dependent pathway for localization of mRNAs encoding membrane-associated proteins.
Hybridization alters maternal and paternal genome contributions to early plant embryogenesis
Authors: Alaniz-Fabián Jaime , Orozco-Nieto Axel , Abreu-Goodger Cei , Gillmor C. Stewart 
Published: October 2022

ABSTRACT
After fertilization, zygotic genome activation results in a transcriptionally competent embryo. Hybrid transcriptome experiments in Arabidopsis have concluded that the maternal and paternal genomes make equal contributions to zygotes and embryos, yet embryo defective (emb) mutants in the Columbia (Col) ecotype display early maternal effects. Here, we show that hybridization of Col with Landsberg erecta (Ler) or Cape Verde Islands (Cvi) ecotypes decreases the maternal effects of emb mutants. Reanalysis of Col/Ler and Col/Cvi transcriptomes confirmed equal parental contributions in Col/Cvi early embryos. By contrast, thousands of genes in Col/Ler zygotes and one-cell embryos were biallelic in one cross and monoallelic in the reciprocal cross, with analysis of intron reads pointing to active transcription as responsible for this parent-of-origin bias. Our analysis shows that, contrary to previous conclusions, the maternal and paternal genomes in Col/Ler zygotes are activated in an asymmetric manner. The decrease in maternal effects in hybrid embryos compared with those in isogenic Col along with differences in genome activation between Col/Cvi and Col/Ler suggest that neither of these hybrids accurately reflects the general trends of parent-of-origin regulation in Arabidopsis embryogenesis.
Perception of health care students towards lectures as a teaching and learning method in the COVID era - A multicentric cross-sectional study from India
Authors: Singh Vijay Pratap , Ramakrishna Anand , Sinha Neloy , Khandelwal Bidita , Joseph Nitin , Barua Purnima 
Published: October 2022

The sudden precipitation of the pandemic forced undergraduates to take refuge at home, deserting the campus. Consequently, the age-old classroom in person teaching-learning (T-L) method shifted and lessons had to be conducted online. In previous decades, archetypical classroom lectures survived a lot of criticism in the face of the quasi-passive nature of T-L methodology. There are very few studies that reflect undergraduate students' perceptions of lectures. This study aimed to evaluate undergraduate students’ perceptions of lectures using an online questionnaire with 13 items, which was circulated to undergraduate students of medical, physiotherapy, and nursing courses in three settings at different locations of private and public health schools. There was a total of 877 responses. The surveyed students were in favor of lectures and considered them indispensable for undergraduate learning. They preferred it as a kind of organized learning through the teacher’s own experiences. Our study suggests that it is not the ‘lecture’ that requires mending but possibly teachers require better training, application of effective audio-visual aids, and innovative techniques to sustain students' interest in the class.
Evaluation of clinical efficacy of Ginkgo biloba extract in the treatment of knee osteoarthritis: a randomized clinical trial
Authors: Al-Haddad Maryam , Bairam Ahsan , Hussain Haider , Majeed Suhad , Al-Jalehawi Ahmad 
Published: October 2022

Background: Osteoarthritis (OA) is a degenerative joint disease characterized by deteriorating articular cartilage. Most patients may not get enough control of symptoms in spite of the availability of various treatment options. Because of the synergistic impact of flavonoids and ginkgolides, Ginkgo biloba (GB) has been shown to possess antioxidant and anti-inflammatory properties besides its generally safe profile. This study aims to assess the efficacy of the Ginkgo biloba extract (GBE) in patient with Knee OA. Methods: This is a randomized double blinded clinical trial conducted in a private orthopaedic clinic in Al-Najaf Government-Iraq. Patients were randomized into two groups; Group A administered the standard treatment (diclofenac capsule 100 milligram sustained released with paracetamol 1 gram twice daily) with GBE 120 milligram twice daily, while Group B administered the standard treatment with placebo (starch) capsule only. The Knee injury and Osteoarthritis Outcome Score (KOOS) was performed to assess the efficacy of the GBE in patient with Knee OA for eight weeks. Results: 60 patients successfully completed the eight weeks follow up. Pain, symptoms, sport, activity of daily living (ADL) scores showed significant improvement in Group A from the first two weeks after treatment with GB in comparison with group B. however, scores of quality of life (QOL) were not significantly improved in two group comparison at each assessment week. Only 10 patients reported gastrointestinal adverse effects during the study which were all mild. Conclusions: GB may provide additional beneficial health effects to patients with knee OA based on KOOS scores when add to the standard treatment regime. Registration: ClincialTrials.gov (NCT05398874, https://clinicaltrials.gov/ct2/show/NCT05398874).
KONSUMSI TABLET TAMBAH DARAH KAITANNYA DENGAN BERAT LAHIR BAYI DI INDONESIA
Authors: Aprisia Betta , Simbolon Demsa 
Published: October 2022

Latar Belakang: Konsumsi tablet tambah darah (TTD) pada ibu hamil yang tidak sesuai dengan rekomendasi minimal 90 tablet selama kehamilan dapat meningkatkan risiko defisiensi zat besi, anemia, dan berat badan lahir rendah (BBLR) yang akan berdampak pada berbagai masalah gizi dan kesehatan dalam siklus kehidupan berikutnya.Tujuan: Penelitian bertujuan mengetahui hubungan konsumsi TTD dengan berat lahir bayidi Indonesia.Metode: Penelitian menggunakan data sekunder Survei Demografi Kesehatan Indonesia (SDKI) tahun 2017 dengan desain cross sectional. Variabel independen adalah konsumsi TTD. Variabel dependen adalah berat lahir bayi. Variabel perancu adalah faktor anak, ibu dan keluarga. Populasi studi penelitian ini sebanyak 12.350 ibu hamil di Indonesia.Sampel penelitian sebanyak 11.735 jiwa yang memenuhi kriteria inklusi. Analisis data menggunakan uji regresi logistik multivariat.Hasil: Hasil penelitian menemukan 6,99% bayi BBLR. Sebesar 49,97% Ibu hamil dengan konsumsi TTD tidak sesuai rekomendasi. Konsumsi TTD berhubungan dengan berat lahir bayi (p=0,003). Konsumsi TTD tidak sesuai rekomendasi berisiko 1,252 (OR95%CI:1,081-1,456) dibandingkan konsumsi TTD sesuai rekomendasi setelah dikontrol dengan faktor pendidikan ibu, status sosial ekonomi keluarga.Simpulan: Konsumsi TTD pada ibu hamil berhubungan dengan berat lahir bayi. Perlu edukasi pentingnya konsumsi TTD minimal 90 butir selama kehamilan dalam upaya pencegahan risiko terjadinya berat lahir rendah (BBLR) pada bayi yang baru lahir, terutama pada keluarga miskin dan pendidikan ibu yang rendah.Kata Kunci: Berat lahir bayi; Konsumsi tablet Fe; Sosial ekonomi; Pendidikan ibu.
CEMARAN MIKROBIOLOGI PADA MAKANAN, ALAT MAKAN, AIR DAN KESEHATAN PENJAMAH MAKANAN DI UNIT INSTALASI GIZI RUMAH SAKIT X DI BANJARMASIN
Authors: Fatimah Siti , Hekmah Nurul , Fathullah Desya Medinasari , Norhasanah Norhasanah 
Published: October 2022

Latar Belakang : Cemaran adalah kejadian yang tidak dikehendaki ada dalam makanan yang mungkin berasal dari lingkungan atau sebagai akibat proses produksi makanan, dapat berupa cemaran biologis, kimia dan benda asing yang dapat mengganggu, merugikan dan membahayakan kesehatan manusia. Mikroba dapat mencemari beberapa aspek seperti makanan, alat makan, air dan kesehatan penjamah makanan.Tujuan : Mengetahuai cemaran mikrobiologi pada makanan, alat makan, air dan kesehatan penjamah makanan di unit instalasi gizi Rumah Sakit X di BanjarmasinMetode : Penelitian menggunakan metode kualitatif dengan jenis penelitian deskriptif. Variabel pada penelitian ini terdiri dari beberapa yaitu cemaran mikrobiologi pada makanan, cemaran mikrobiologi pada alat makan, cemaran mirobiologi pada air dan cemaran mikrobiologi pada kesehatan penjamah makanan. Cara pengukuran pada penelitian ini menggunakan metode Total Plate Count (TPC) untuk sampel makanan dan sampel swab dubur, Colony Forming Unit (CFU) untuk sampel alat makan, metode Most Probable Number (MPN) untuk sampel air, metode. Sampel penelitian ini terdiri dari beberapa jenis sampel yang telah dilakukan pemeriksaan laboratorium seperti 24 sampel makanan, 4 sampel alat makan, 6 sampel air dan 18 sampel rectal swab.Hasil : Hasil pemeriksaan laboratorium menunjukkan seluruh sampel makanan dan kesehatan penjamah makanan menunjukkan hasil memenuhi syarat, sedangkan untuk hasil pemeriksaan cemaran pada air kran terdapat 1 sampel air kran yang tidak memenuhi syarat serta pada alat makan terdapat 2 sampel alat makan yang tidak memenuhi syarat.Simpulan : Tidak ada bukti kontaminasi mikrobiologis dalam sampel makanan atau kesehatan penjamah makanan. Sementara itu, beberapa sampel menunjukkan bakteri dalam air keran dan peralatan makan. Dua sampel sampel alat makan mengandung bakteri patogen, dan satu sampel air kran mengandung bakteri ColiKata Kunci : Alat makan; Air; Cemaran mikrobiologi; Penjamah makanan.
Translanguaging as a pedagogy: exploring the use of teachers’ and students’ bilingual repertoires in Chinese language education
Authors: Han Jinghe 
Published: October 2022

Abstract
This research offers a post-structuralist multilingual lens to examine translanguaging practice in Chinese as an Additional Language (CAL) teaching and learning. It investigates a cohort of bilingual Chinese teachers who had been trained in a teacher-researcher education programme in an Australian university. This research asks how the Chinese teachers utilised their own and their students’ bilingual repertoires to assist the learning of Chinese in Australian schools. The participant teachers’ theses were collected, and the evidentiary chapters reporting on their classroom teaching were analysed. Informed by the initial results, a follow-up stimulated recall interview was conducted. This research found that the teachers’ translanguaging practices were identified in the form of theirs and their students’ lingual and non-lingual capitals, and these practices showed a strong pedagogical purpose, particularly in motivating and engaging learners. The teachers’ translanguaging practices contributed to CAL pedagogy across three dimensions: teachers’ classroom instruction, teaching and learning resources, and learning activity design. These practices have demonstrated an impact on the students’ engagement, the enrichment of teaching content and improvement in dynamic teaching processes. This research is expected to provide insights into the future development of translanguaging curriculum and pedagogy in CAL education.
A review: Silver–zinc oxide nanoparticles – organoclay-reinforced chitosan bionanocomposites for food packaging
Authors: Muiz Lisna Junaeni , Juwono Ariadne Lakshmidevi , Krisnandi Yuni Krisyuningsih 
Published: October 2022

AbstractResearch on bionanocomposites has been developed, while its application as food packaging is still being explored. They are usually made from natural polymers such as cellulose acetate, chitosan (CS), and polyvinyl alcohol. Bionanocomposite materials can replace traditional non-biodegradable plastic packaging materials, enabling them to use new, high-performance, lightweight, and environmentally friendly composite materials. However, this natural polymer has a weakness in mechanical properties. Therefore, a composite system is needed that will improve the properties of the biodegradable food packaging. The aim of this mini-review is to demonstrate recent progress in the synthesis, modification, characterization, and application of bionanocomposites reported by previous researchers. The focus is on the preparation and characterization of CS-based bionanocomposites. The mechanical properties of CS-based food packaging can be improved by adding reinforcement from inorganic materials such as organoclay. Meanwhile, the anti-bacterial properties of CS-based food packaging can be improved by adding nanoparticles such as Ag and ZnO.
The Mediated Engagement of Switzerland with BRI: A Transnational Comparative Framing Analysis
Authors: Zhang Zhan 
Published: October 2022

Abstract
This paper offers a transnational comparative framing analysis of leading legacy news media in Switzerland (Neue Zürcher Zeitung, abbreviated to NZZ, in German) and China (China Daily in English) in their coverage of Swiss engagement with the Belt and Road Initiative (BRI) in 2017 and 2019. The results implied a clear dominance of both newspapers’ economic and political actors and related frames. By introducing a geopolitical frame into the generic frame categories and adding an economy-driven frame into domestic frame categories based on the current framing pool from Transcultural Comparative Framing Model (TCFM), the study discussed how the two newspapers shared the same focus by frequency but differed from each other in the contextual discourse through argumentation. China Daily preferred to report from a general and positive overview, focusing on bilateral relations between China and Switzerland. In contrast, NZZ intended to cover more about specific Swiss industries and international actors such as the European Union and the United States, presenting a hybrid perspective towards BRI. The study found a clear presence of ideology-driven and political-position-driven frames on both newspapers—NZZ in particular. Given the importance of cultural congruence in framing studies, the study calls for an inclusion of more cultural notions and a general transcultural frame for reporting and researching emerging transnational topics through TCFM. Only when a discursive space is created with respect to different cultural patterns, might resonation in communicative encounters and conceptualization repertoires become possible.
Gift-Giving and the Seventh-Century Frankish Church in Merovingian Hagiography: The case of the Vita Eligii
Authors: Visintini Eduard 
Published: October 2022

Abstract
This paper argues for the combination of political and socio-economic analysis in the study of early medieval gift-giving, specifically in the context of the late Merovingian Church. Gift-giving in this period is often viewed through a historiographical tradition strongly influenced by anthropological scholarship, which rarely considers any socio-economic reasoning behind the act – particularly in the case of ecclesiastical institutions and actors. This paper associates itself with the recent and growing answer to this position, and particularly to Ian Wood’s re-working of Appadurai and Appadurai Breckenridge’s “Temple Societies” theory. It studies the political, social, and economic context and repercussions of gift-giving in the Life of Saint Eligius, a seventh-century craftsman, member of the Merovingian court, and subsequently bishop of the see of Noyon, in North-Eastern Francia. The paper analyses the vita in a threefold way: Firstly, it looks at the connection between political patronage and gift-giving through the saint’s relationship to the Merovingian court. Secondly, it considers the potential socio-economic effects of gift-giving on the ecclesiastical institutions described throughout the text, and on the societies around them. Thirdly, it interprets these aspects in the light of the political expansion of the Merovingian Church, and of its institutions, in eastern Gaul.