bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding conversational interaction in multiparty conversations: the EVA Corpus
Authors: Mlakar Izidor , Verdonik Darinka , Majhenič Simona , Rojc Matej 
Published: December 2022

AbstractThis paper focuses on gaining new knowledge through observation, qualitative analytics, and cross-modal fusion of rich multi-layered conversational features expressed during multiparty discourse. The outlined research stems from the theory that speech and co-speech gestures originate from the same representation; however, the representation is not solely limited to the speech production process. Thus, the nature of how information is conveyed by synchronously fusing speech and gestures must be investigated in detail. Therefore, this paper introduces an integrated annotation scheme and methodology which opens the opportunity to study verbal (i.e., speech) and non-verbal (i.e., visual cues with a communicative intent) components independently, however, still interconnected over a common timeline. To analyse this interaction between linguistic, paralinguistic, and non-verbal components in multiparty discourse and to help improve natural language generation in embodied conversational agents, a high-quality multimodal corpus, consisting of several annotation layers spanning syntax, POS, dialogue acts, discourse markers, sentiment, emotions, non-verbal behaviour, and gesture units was built and is represented in detail. It is the first of its kind for the Slovenian language. Moreover, detailed case studies show the tendency of metadiscourse to coincide with non-verbal behaviour of non-propositional origin. The case analysis further highlights how the newly created conversational model and the corresponding information-rich consistent corpus can be exploited to deepen the understanding of multiparty discourse.
The potential and shortcomings of mitochondrial DNA analysis for cheetah conservation management
Authors: Meißner René , Winter Sven , Westerhüs Uta , Sliwa Alexander , Greve Carola , Bottriell Lena Godsall , Bottriell Paul , Fernandes Carlos Rodríguez , Vercammen Paul , Hunter Luke T. B. , Abramov Alexei V. , Khalatbari Leili , Horin Petr , Burger Pamela A. , Prost Stefan 
Published: December 2022

AbstractThere are only about 7,100 adolescent and adult cheetahs (Acinonyx jubatus) remaining in the wild. With the majority occurring outside protected areas, their numbers are rapidly declining. Evidence-based conservation measures are essential for the survival of this species. Genetic data is routinely used to inform conservation strategies, e.g., by establishing conservation units (CU). A commonly used marker in conservation genetics is mitochondrial DNA (mtDNA). Here, we investigated the cheetah’s phylogeography using a large-scale mtDNA data set to refine subspecies distributions and better assign individuals to CUs. Our dataset mostly consisted of historic samples to cover the cheetah’s whole range as the species has been extinct in most of its former distribution. While our genetic data largely agree with geography-based subspecies assignments, several geographic regions show conflicting mtDNA signals. Our analyses support previous findings that evolutionary forces such as incomplete lineage sorting or mitochondrial capture likely confound the mitochondrial phylogeography of this species, especially in East and, to some extent, in Northeast Africa. We caution that subspecies assignments solely based on mtDNA should be treated carefully and argue for an additional standardized nuclear single nucleotide polymorphism (SNP) marker set for subspecies identification and monitoring. However, the detection of the A. j. soemmeringii specific haplogroup by a newly designed Amplification-Refractory Mutation System (ARMS) can already provide support for conservation measures.
Hyperintensionality and Ontological Categories
Authors: Miller J. T. M. 
Published: December 2022

AbstractIn this paper, I discuss how to distinguish between ontological categories and ordinary categories. Using an argument against van Inwagen’s proposed account of what makes a category ontological as a springboard, I argue that if ontological categories are modally robust, then ontological categories need to be understood hyperintensionally. This conclusion opens up a wide range of new ways to define ‘ontological category’, and I close by briefly outlining one such way in order to illustrate the advantages of embracing hyperintensionality in this debate.
Usability Evaluation of Imikode Virtual Reality Game to Facilitate Learning of Object-Oriented Programming
Authors: Sunday Kissinger , Oyelere Solomon Sunday , Agbo Friday Joseph , Aliyu Muhammad Bello , Balogun Oluwafemi Samson , Bouali Nacir 
Published: December 2022

AbstractMany empirical studies have shown that educational games and recent technologies impact education and increase learning effectiveness, students’ motivation and engagement. The overall aim of this study is to evaluate the usability of Imikode, a virtual reality (VR) game that was developed to introduce the concepts of object-oriented programming to novices. The improved version of the Imikode VR game consists of three features: An artificial intelligence component designed to provide real-time error feedback to users, an intelligent agent that guides and teaches users how to play the game and finally, the integration of multiple game play that gives learners more opportunities to explore the VR environment for greater immersive learning experience. This study adopted a survey approach and recruited first-year computer science students to measure learner satisfaction with educational virtual reality games and examined the correlations among the attributes of the Usefulness, Satisfaction and Ease of Use questionnaire of usage of Imikode. The results showed that the students were satisfied with Imikode and perceived the virtual reality educational game as very useful for learning object-oriented programming concepts. In addition, there was a correlation among the questionnaire variables, which means that researchers can use the instrument for future usability studies in the context. We further proffered some design recommendations for building software tools.
No Evidence of Responding Individuals Constraining the Evolution of the Pheromone Signal in the Pine Engraver Ips avulsus
Authors: Queffelec Joséphine , Sullivan Brian , Mckenney Jessica L , Allison Jeremy D 
Published: December 2022

AbstractChemical signals are important mediators of interactions within forest ecosystems. In insects, pheromone signals mediate intraspecific interactions such as mate location and acceptance. The evolution of pheromones in insects has been mostly studied from a theoretical perspective in the Lepidoptera. With this study, we aimed to broaden our understanding of pheromone communication in bark beetles. We first demonstrated that the enantiomeric ratios of ipsdienol produced by maleI. avulsus, showed little variation. Subsequently, with field trapping trials we characterized the influence of the enantiomeric ratio of ipsdienol (pheromone component ofI. avulsus) onI. avulsuscaptures and observed a great amount of variation in the receiver preference function. Most importantly, we demonstrated that responding individuals responded indiscriminately to all the enantiomeric ratios produced by the emitting individuals. These observations are consistent with the asymmetric tracking model which postulates that if the limiting sex is the emitting sex, responding individuals should not discriminate between emitted ratios. Consequently, responding individuals do not constrain the evolution of the signal. Our data suggest that, inI. avulsus, the composition of the aggregation pheromone signal might be more responsive to external selection forces, such as predation and metabolic constraints, as suggested by the asymmetric tracking model.
A new one-step method with three intermediate points in a variable step-size mode for stiff differential systems
Authors: Ramos Higinio , Rufai Mufutau Ajani 
Published: December 2022

AbstractThis work introduces a new one-step method with three intermediate points for solving stiff differential systems. These types of problems appear in different disciplines and, in particular, in problems derived from chemical reactions. In fact, the term “stiff”’ was coined by Curtiss and Hirschfelder in an article on problems of chemical kinetics (Hirschfelder, Proc Natl Acad Sci USA 38:235–243, 1952). The techniques of interpolation and collocation are used in the construction of the scheme. We consider a suitable polynomial to approximate the theoretical solution of the problem under consideration. The basic properties of the new scheme are analyzed. An embedded strategy is adopted to formulate the proposed scheme in a variable stepsize mode to get better performance. Finally, some models of initial-value problems, including ordinary and time-dependent partial differential equations, are solved numerically to assess the performance and efficiency of the proposed technique, with applications to real-world problems.
Intercomparison exercise on difficult to measure radionuclides in spent ion exchange resin
Authors: Leskinen Anumaija , Dorval Eric , Baudat Emilie , Gautier Celine , Stordal Solveig , Salminen-Paatero Susanna 
Published: December 2022

AbstractA need for method validation in radiochemical analyses of decommissioning waste is a challenging task due to lack of commercial reference materials. Participation in an intercomparison exercise is one way for a laboratory to assess their performance and validate their analysis results. A three-year project within the Nordic Nuclear Safety Research (NKS) community was initiated in order to carry out intercomparison exercises on difficult to measure (DTM) radionuclides in real decommissioning waste. Both Nordic and Non-Nordic laboratories participated. This paper reports the results from the final year of the project focusing on beta- and gamma emitter (i.e., easy to measure, ETM) analysis in spent ion exchange resin. The assigned values were derived from the participants’ results according to ISO 13528 standard and the performances were assessed using z scores. The results showed generally good performances for both DTMs and ETMs.
The representation of feedback literature in classroom observation frameworks: an exploratory study
Authors: Ruelmann Merle , Charalambous Charalambos Y. , Praetorius Anna-Katharina 
Published: December 2022

AbstractFeedback is considered of great relevance for supporting student learning. It is therefore the focus of a significant body of theoretical work and is included in many observation frameworks for measuring teaching quality. However, little is currently known about the extent to which the theoretical and empirical knowledge of feedback from the literature is represented in operationalizations of feedback in observation frameworks. In this exploratory study, we first reviewed the literature and identified nine quality criteria for effective feedback. Using content analysis, we then explored the extent to which 12 widely used observation frameworks for teaching quality reflect these criteria and the similarities and differences in their approaches to capturing feedback quality. Only ten of the 12 frameworks measured feedback. Nine frameworks addressed feedback directly, while one framework only captured feedback indirectly. All frameworks differed in the number of feedback quality criteria they captured, the aspects they focused on for each one, and the detail in which they described them. One criterion (Feed Up) was not captured by any framework. The results show that more clarity is needed about which facets of feedback are integrated into frameworks and why. The study also highlights the importance of finding ways to complement observation frameworks with other measures so that feedback quality is captured in a more comprehensive fashion.
An experience- and preference-based EQ-5D-3L value set derived using 18 months of longitudinal data in patients who sustained a fracture: results from the ICUROS
Authors: Svedbom Axel , Borgstöm Fredrik , Hernlund Emma , Alekna Vidmantas , Bianchi Maria Luisa , Clark Patricia , Diaz-Curiel Manuel , Dimai Hans Peter , Jürisson Mikk , Lesnyak Olga , McCloskey Eugene , Sanders Kerrie M. , Silverman Stuart , Tamulaitiene Marija , Thomas Thierry , Tosteson Anna N. A. , Jönsson Bengt , Kanis John A. 
Published: December 2022

Abstract
Introduction
EQ-5D-3L preference-based value sets are predominately based on hypothetical health states and derived in cross-sectional settings. Therefore, we derived an experience-based value set from a prospective observational study.

Methods
The International Costs and Utilities Related to Osteoporotic fractures Study (ICUROS) was a multinational study on fragility fractures, prospectively collecting EQ-5D-3L and Time trade-off (TTO) within two weeks after fracture (including pre-fracture recall), and at 4, 12, and 18 months thereafter. We derived an EQ-5D-3L value set by regressing the TTO values on the ten impairment levels in the EQ-5D-3L. We explored the potential for response shift and whether preferences for domains vary systematically with prior impairment in that domain. Finally, we compared the value set to 25 other EQ-5D-3L preference-based value sets.

Results
TTO data were available for 12,954 EQ-5D-3L health states in 4683 patients. All coefficients in the value set had the expected sign, were statistically significant, and increased monotonically with severity of impairment. We found evidence for response shift in mobility, self-care, and usual activities. The value set had good agreement with the only other experience- and preference-based value set, but poor agreement with all hypothetical value sets.

Conclusions
We present an experience- and preference-based value set with high face validity. The study indicates that response shift may be important to account for when deriving value sets. Furthermore, the study suggests that perspective (experienced versus hypothetical) is more important than country setting or demographics for valuation of EQ-5D-3L health states.
Outward-facing epistemic vice
Authors: Harris Keith Raymond 
Published: December 2022

AbstractThe epistemic virtues and vices are typically defined in terms of effects or motivations related to the epistemic states of their possessors. However, philosophers have recently begun to consider other-regarding epistemic virtues, traits oriented toward the epistemic flourishing of others. In a similar vein, this paper discusses outward-facing epistemic vices, properties oriented toward the epistemic languishing of others. I argue for the existence of both reliabilist and responsibilist outward-facing vices, and illustrate how such vices negatively bear on the epistemic prospects of others. I pay special attention to how outward-facing epistemic vices may manifest in online activities that promote the epistemic languishing of others by negatively influencing the online epistemic environment.
Game analogy in law reconsidered: is evidence at stake?
Authors: Dybowski Maciej , Dzięgielewska Weronika , Rzepiński Wojciech 
Published: December 2022

AbstractThe aim of this paper is to show that the meaning and significance of legal evidence is being constituted throughout the course of a singular instance of legal proceedings. This is to be achieved by describing what legal agents do while appealing to different propositions of fact and inferring from them throughout the course of legal proceedings. The authors claim that the process of applying the law is ultimately rooted in the inferential discursive practices of exchanging reasons on the part of the participants of legal proceedings. Therefore, they set forth a model of legal proceedings that consists of an interplay between three types of reasons, which are exchanged by the participants of legal proceedings: i.e. legal reasons, epistemic reasons and stake reasons. To illustrate this interplay, the authors deploy a metaphor of law as a game, and provide a description of legal proceedings as a particular instance of playing a game of law. The conclusion is that the legal concept of evidence is (at least in part) constituted by the role that evidence plays in affecting which reasons for action the participants to legal proceedings choose to act on. The other final assumption of this paper is metatheoretical: authors want to show that when analyzing what legal evidence is, one should begin from the perspective of a singular instance of legal proceedings, rather than from the perspective of law in general.
Independent risk factors for an increased incidence of thromboembolism after lung transplantation
Authors: Moneke Isabelle , Ogutur Ecem Deniz , Kalbhenn Johannes , Hettich Ina , Passlick Bernward , Jungraithmayr Wolfgang , Senbaklavaci Omer 
Published: December 2022

Abstract
Background
Thromboembolism (TE) after lung transplantation (LTX) is associated with increased morbidity and mortality. The aim of this study is to analyze the incidence and outcome of venous and arterial thromboembolic complications and to identify independent risk factors.

Patients and methods
We retrospectively analyzed the medical records of 221 patients who underwent LTX at our institution between 2002 and 2021. Statistical analysis was performed using SPSS and GraphPad software.

Results
74 LTX recipients (33%) developed TE. The 30-days incidence and 12-months incidence were 12% and 23%, respectively. Nearly half of the patients (48%) developed pulmonary embolism, 10% ischemic stroke. Arterial hypertension (p = 0.006), a body mass index (BMI) > 30 (p = 0.006) and diabetes mellitus (p = 0.041) were independent predictors for TE. Moreover, a BMI of > 25 at the time of transplantation was associated with an increased risk for TE (43% vs. 32%, p = 0.035). At the time of LTX, 65% of the patients were older than 55 years. An age > 55 years also correlated with the incidence of TE (p = 0.037) and these patients had reduced overall post-transplant survival when the event occurred within the first postoperative year (59% vs. 72%, p = 0.028).

Conclusions
The incidence of TE after LTX is high, especially in lung transplant recipients with a BMI > 25 and an age > 55 years as well as cardiovascular risk factors closely associated with the metabolic syndrome. As these patients comprise a growing recipient fraction, intensified research should focus on the risks and benefits of regular screening or a prolonged TE prophylaxis in these patients.
Trial registration number DKRS: 00021501.
The impact of environmental change on landslides, fatal landslides, and their triggers in Pakistan (2003–2019)
Authors: Shabbir Waqas , Omer Talha , Pilz Jürgen 
Published: December 2022

Abstract
The actual impact of landslides in Pakistan is highly underestimated and has not been addressed to its full extent. This study focuses on the impact which landslides had in the last 17 years, with focus on mortality, gender of deceased, main triggers (landslides and fatal landslides), and regional identification of the hotspots in Pakistan. Our study identified 1089 landslides (including rockfalls, rockslides, mudslides, mudflows, debris flows) out of which 180 landslides were fatal and claimed lives of 1072 people. We found that rain (rainfall and heavy rainfall)-related landslides were the deadliest over the entire study period. The main trigger of landslides in Pakistan is heavy rainfall which comprises over 50% of the triggers for the landslide, and combined with normal rainfall, this rate climbs to over 63%. The second main reason for landslide occurrence is spontaneous (due to rock instability, erosion, climate change, and other geological elements) with landslides accounting for 22.3% of all the landslides. Landslides caused by rain-related events amounted to 41.67% of the fatalities, whereas spontaneous landslides caused 29.44% of the deaths and the human induced events accounted for 25.5% of the fatalities. The fatal landslides accounted for 19.53% deaths of the children. Our study also found that more than 48% of the deadly landslides occurred between the months of January to April, whereas the least fatal landslides occurred in the month of June which accounted for only 3% of all the fatal landslides in Pakistan.
Developmental exposure to triclosan and benzophenone-2 causes morphological alterations in zebrafish (Danio rerio) thyroid follicles and eyes
Authors: Kraft Maximilian , Gölz Lisa , Rinderknecht Maximilian , Koegst Johannes , Braunbeck Thomas , Baumann Lisa 
Published: December 2022

Abstract Thyroid hormones (THs) regulate a multitude of developmental and metabolic processes, which are responsible for vertebrate development, growth, and maintenance of homeostasis. THs also play a key role in neurogenesis of vertebrates and thus affect eye development, which is vital for foraging efficiency and for effective escape from predation. Currently, there are no validated test guidelines for the assessment of TH system-disrupting chemicals (THSDCs) in fish. Consequently, the present study was designed to demonstrate the suitability of novel thyroid-related endpoints in early life-stages of fish. Embryos of a transgenic zebrafish (Danio rerio) line expressing the reporter gene tg:mCherry in their thyrocytes were used to investigate the effects of the environmental THSDCs triclosan (TCS, antibacterial agent) and benzophenone-2 (BP-2, UV filter) on thyroid follicle and eye development. Both BP-2 and TCS caused thyroid follicle hyperplasia in transgenic zebrafish, thus confirming their role as THSDCs. The effect intensity on follicle size and fluorescence was comparable with a 1.7-fold increase for BP-2 and 1.6-fold for TCS. Alterations of the cellular structures of the retina indicate an impact of both substances on eye development, with a stronger impact of TCS. With respect to guideline development, results provide further evidence for the suitability of morphological changes in thyroid follicles and the eyes as novel endpoints for the sensitive assessment of THSD-related effects in fish.
Living in the twilight zone: a qualitative study on the experiences of patients with advanced cancer obtaining long-term response to immunotherapy or targeted therapy
Authors: Zwanenburg Laura C. , Suijkerbuijk Karijn P. M. , van Dongen Sophie I. , Koldenhof José J. , van Roozendaal Anne S. , van der Lee Marije L. , Schellekens Melanie P. J. 
Published: December 2022

Abstract

Purpose
The introduction of immunotherapy and targeted therapy has drastically improved the life expectancy of patients with advanced cancer. Despite improved survival, obtaining long-term response can be highly distressing and comes with uncertainties that affect several life domains. The aim of this study is to gain a deeper understanding of long-term responders’ lived experiences with obtaining long-term response to immunotherapy or targeted therapy.

Methods
We conducted an exploratory qualitative study using thematic data analysis. Semi-structured in-depth interviews were conducted with 17 patients with advanced melanoma or lung cancer who had a confirmed response to or long-term stable disease while on immunotherapy or targeted therapy.

Results
Long-term responders are living in a twilight zone, where they neither feel like a patient, nor feel healthy. This impacts their self-image, interactions with their social environment, and feelings of uncertainty. Due to their uncertain life perspective, long-term responders are going back and forth between hope and despair, while they are longing for their ‘old’ life, several barriers, such as protective behavior of the social environment, force them to adjust to a life with cancer.

Conclusion
Long-term responders are facing many challenges, such as searching for a renewed identity, dealing with ongoing uncertainty, and having to adapt to a new normal. This emphasizes the importance of providing this new patient group with tailored information and support.

Implications for Cancer Survivors
Healthcare professionals can support patients by normalizing their feelings and providing space for varying emotions. Using patient-tailored scan frequencies could help temper fear of progression.