bluuebunny/crossref_metadata_2025_split huggingface dataset:
Book Review: Applications of Ion Exchange Materials in Chemical and
Food Industries
Authors: Balla Putrakumar , Ginjupalli Srinivasa Rao , Pothu Ramyakrishna , Boddula Rajender , Perugopu Vijayanand 
Published: April 2022

Abstract:
A Book entitled Applications of Ion Exchange Materials in published by Chemical and Food
Industries Edited by Inamuddin, Abdullah M. Asiri, and Tauseef Ahmad Rangreez, Springer, in 2019, (Print
ISBN 978-3-030-06084-8, ISBN 978-3-030-06085-5, DOI: 10.1007/978-3-030-06085-5)
This book provides an up-to-date, complete overview of various applications of ion exchange resins in the
chemical and food industry.
The chemistry of ion exchange resin materials towards its allied applications, including deionization,
dealkalization, dehydration, hydrogenation, esterification, reactive separation, synthesis, separation, and
purification of industrial products, were well addressed in this book, along with drawbacks and future
scope to improve for better performance on the industrial scale.
This book consists of nine chapters. Altogether, they discuss the applications of ion exchange resins in
solid acid catalysis, reaction separation, removal, and recovery of metals in chemical reactions, and preparation
of Ag-aggregated ion-exchanged silicates, specifically as it is not possible to discuss each and everything
in detail. The chapters are presented effectively by reputed experts around the world. That makes
this book an exceptionally significant and authentic source of information. It is valuable for a book to
provide updated information, review the work done to date, do proper analysis, compare the pros and
cons of comparable existing technologies, and guide the reader to research gaps and places where improvement
is required.
This book is an essential reference guide for students, researchers, engineers, professionals, and industrial
research and development specialists in chemistry, chemical and biochemical technology, food chemistry,
synthetic chemistry, and industrial chemistry.

Results:
This book consists of nine chapters. Altogether, they discuss the applications of ion exchange resins in solid acid catalysis, reaction separation, removal and recovery of metals in chemical reactions, and preparation of Ag-aggregated ion-exchanged silicates, specifically as it is not possible to discuss each and everything in detail. The chapters are presented effectively by reputed experts around the world. That makes this book an exceptionally significant and authentic source of information. It is valuable for a book to provide updated information, review the work done to date, do proper analysis, compare the pros and cons of comparable existing technologies, and guide the reader to research gaps and places where improvement is required.

Conclusion:
This book is an essential reference guide for students, researchers, engineers, professionals, and industrial research and development specialists in chemistry, chemical and biochemical technology, food chemistry, synthetic chemistry, and industrial chemistry.
Pharmacovigilance in Herbal Drugs: A Challenge
Authors: Subraya Chandrashekar Kodangala , Sanghvi Kemisha , Pai Vasudev , Nanjundaiah Aswatha Ram Holavanna Halli , Kunhikatta Vijayanarayana 
Published: April 2022

Abstract:
There is a growing awareness of a disease at many levels, its treatment, and treatment
outcomes including side effects. Alternative therapy techniques, herbal medicines and formulations
are extensively acknowledged and practiced in India and around the world. Herbal medicine is usually
considered being safe regardless of the absence of scientific evidence to support its claims. Several
issues concerning the methods in which herbal medications are labelled, evaluated, sourced, and used
are connected to herbal medicine. Herbal therapeutics in the management and treatment of diabetes,
rheumatism, hepatic disorders and other mild to chronic diseases and disorders are widely accepted.
However, the adversities are difficult to recognize. The idea that the nature is safe and may be taken
without the prescription of a physician has resulted in widespread self-medication across the world,
sometimes with disappointing results, side effects, or unpleasant after-effects. The existing pharmacovigilance
paradigm and its accompanying tools were created in connection with synthetic medicines.
Nevertheless, adopting these approaches to keep records of herbal medications’ safety poses a
distinct challenge. This might be due to the variations in the usage of non-traditional medicines,
which can offer unique toxicological issues whether taken alone or in conjunction with other medications.
The goal of pharmacovigilance is to identify, analyse, explain, and minimize the adverse reactions
and other drug-related complications associated with herbal, traditional, and complementary
medications. Systematic pharmacovigilance is required to collect accurate data on the safety of herbal
medications to create adequate guidelines for effective and safe usage.
Antibiotic Prophylaxis for Orthopaedic Implant Removal: What Does the
Evidence Say?
Authors: Shafiq Nusrat , Rather Imran Ibni Gani , Pandey Avaneesh Kumar , Bhandari Ritika Kondel , Malhotra Samir , Chouhan Devinder Kumar 
Published: April 2022

Abstract:
Orthopaedic implant removal is considered a sterile procedure, but the current literature
suggests it is associated with around a 20% Surgical Site Infection (SSI) rate. The use of antibiotic
prophylaxis is still ambiguous and contentious. Taking into consideration this issue we conducted a
meta-analysis for the use of antibiotic prophylaxis in orthopaedic implant removal surgery.

Objectives:
To determine whether or not antibiotic prophylaxis benefits orthopaedic implant removal
surgeries.

Methods:
Electronic and printed sources were searched up to February 2021 for randomised controlled
trials (RCTs) using antibiotic prophylaxis and a control group. Data from eligible studies
were pooled for the following outcomes: overall, superficial, and deep surgical site infection (SSI).
Pooled odds ratios with a 95% confidence interval (CI) were calculated using Mantel Haenszel
fixed-effect model preferentially.

Results::
Two studies, including 766 patients were included in this meta-analysis. Heterogeneity
was not statistically significant between the studies. There was no significant difference in the incidence
of overall SSI in cefazolin and normal saline (NS) groups (Pooled OR 0.79; 95% CI 0.53-
1.17). In subgroup analysis, antibiotic prophylaxis showed statistically significant improvement for
deep SSI (Pooled OR 0.20; 95% CI 0.06-0.70).

Conclusion::
Overall incidence of SSI is not reduced after the administration of antibiotic prophylaxis
one hour before removal of orthopaedic implants.
Regenerative Therapy Approaches and Encountered Problems in Sensorineural
Hearing Loss
Authors: Kelleci Kübra , Golebetmaz Eda 
Published: April 2022

Abstract:
Hearing loss is one of the most important public health matters worldwide, severely affecting
people's social, psychological, and cognitive development.
The perception of sound, movement, and balance in vertebrates depends on a special sensory organ called
the cochlea, which contains hair cells and supporting cells in the inner ear. Genetic factors, epigenetics,
the use of ototoxic drugs (some antibiotics and chemotherapeutics), noise, infections, or even aging can
cause loss of hair cells and their related primary neurons, leading to sensorineural hearing loss. Although
a sensorineural hearing loss, also known as permanent hearing loss, is treated with hearing aids and cochlear
implants, treatment methods are limited. Since even the best implant cannot exhibit the characteristics
of the original ear, the permanent sensory deficit will be permanent.
For this reason, it has become important to develop regenerative treatment methods to regenerate and
replace lost or damaged hair cells and neurons. Developments in stem cell technology have led to promising
studies in regenerating damaged/lost hair cells or neurons with endogenous or exogenous cell-based
therapies. Epigenetic mechanisms can turn hearing-related genes on and off and determine which proteins
to copy. In addition, due to gene silencing, gene replacement, and CRISPR/CAS9 technology, gene therapy
methods have accelerated, and studies have been carried out to treat dominant and recessive mutations
that cause genetic-induced hearing loss or increase hair cell regeneration.
In this paper, potential gene therapy and stem cell applications in the acquisition of cochlear function,
which causes sensorineural hearing loss, and the difficulties encountered in these applications are compiled
from a bioengineering perspective.
A Simple and Practical microRNA-based Nomogram to Predict Metastatic
HCC
Authors: Zhu Yong , Jie Yusheng , Wu Yuankai , Tang Wenting , Cao Jing , Su Zhongzhen , Zhuo Zhenjian , Gong Jiao , Chong Yutian 
Published: April 2022

Background:
Despite unprecedented scientific progress that has been achieved over the
years, there is no established microRNA-based model for predicting hepatocellular carcinoma (HCC)
metastasis. To this end, we aimed to develop a simple model based on the expression of miRNAs to
identify patients at high risk of metastatic HCC.

Methods:
HCC datasets with metastasis data were acquired from the Gene Expression Omnibus (GEO)
database, and samples were randomly divided into training (n=169) and validation (n=72) groups.
Based on the expression of miRNAs in the training group, we developed a predictive nomogram for
metastatic HCC. We evaluated its performance using the area under the receiver operating characteristic
curve (AUC), calibration curve, decision curve and clinical impact curve analysis.

Results:
By applying the absolute shrinkage and selection operator regression (LASSO) and multivariate
logistic regression, it has been found that the expressions of miR-30c, miR-185, and miR-323 were
independent predictors of metastatic HCC. These miRNAs were used to construct a nomogram that
yielded good performance in predicting metastasis in training (AUC 0.869 [95% CI 813-0.925], sensitivity
92.7%, specificity 57.8%) and validation groups (0.821 [CI 0.720-0.923], sensitivity 94.7%, specificity
60%). The calibration curve showed a good agreement between actual and predicted outcomes.
Decision curve analysis showed a high clinical net benefit of nomogram predictions for our patients.
Moreover, higher total scores of our nomogram were associated with dead patients. In addition, functional
enrichment analysis showed that the predicted target genes of these 3 miRNAs correlated with
tumor metastasis-associated terms, such as filopodium, and identified their related hub genes.

Conclusions:
Our easy-to-use nomogram could assist in identifying HCC patients at high risk of metastasis,
which provides valuable information for clinical treatment.
A Review on Autism Spectrum Disorder: Pathogenesis, Biomarkers,
Pharmacological and Non-Pharmacological Interventions
Authors: Majhi Sagarika , Kumar Sokindra , Singh Lubhan 
Published: April 2022

Abstract:
Autistic spectrum disorder (ASD) is a complicated developmental disease characterized by
persistent difficulties in social interaction, speech and nonverbal communication, and restricted/
repetitive activities. Our goal is to deliver a step ahead awareness on neurodevelopment in ASD
through early behavioral screenings, genetic testing, and detection of various environmental triggers.
This would significantly reduce the tally of people with autistic characteristics. As of now, much work
is to be done in understanding and treating ASD. Firstly, awareness campaigns must be organized and
maintained so that ASD children can be identified and treated feasibly. Secondly, prenatal and prepregnancy
environmental risk awareness, including advice against consanguineous marriages, information
on optimum mother nutrition, and minimizing pollutants exposure, can be focused. Finally, the
extension of genetic screening along with early postnatal monitoring of newborn feeding, nutrition,
and eye contact will help in early therapy. People with ASD have strict dietary habits, but they are also
more prone to gastrointestinal problems, including diarrhoea, constipation, and sometimes irritable
bowel syndrome. Despite significant studies on the symptoms and possible causes of ASD, GI dysfunction
is becoming a hot issue of discussion. Dietary strategies can partially help to alleviate both GI
and behavioural issues due to the link between gut-microbiota and brain activity. Dietary treatments
may be less expensive, easier to administer and have fewer adverse effects than pharmacological interventions.
Hence, there is an increasing interest in autistic children's customized diets and supplements.
Future studies should look at whether these diets are applicable to diverse people and whether
they are practical in various circumstances (areas with fewer resources, lower socioeconomic areas,
countries with different dietary restrictions, etc.). The dietary phytochemicals, including curcumin,
resveratrol, naringenin, and sulforaphane, have a substantial role as neurotherapeutic agents. These
agents can act as an antioxidant, immunomodulator, gut microbiota modulator and Nrf2 activator to
provide benefits to ASD patients. Hence an urgent need is to create brain-targeted delivery methods
for these dietary phytochemicals and to investigate their therapeutic value in ASD.
Curcumin: A Review of its’ Efficacy in the Management of Psoriasis
Authors: Reena K.M. , Singh Lalit , Sharma Shipra 
Published: April 2022

Background:Psoriasis is a long-term chronic inflammatory, autoimmune and reoccur-ring skin condition. About 2% to 5% of the world's population is impacted by psoriasis. People af-fected by psoriasis are more prone to develop other health conditions including psoriatic arthritis, anxiety, depression and cardiovascular disorders. Long-term use of several synthetic medications used for their management has been showing typical severe side effects. Curcumin, a natural com-pound generated from the golden spice (Curcuma longa), has been recommended as a potential al-ternative for the management of psoriasis. Curcumin works at molecular level by binding with the various inflammatory receptors that play a key role in the initiation of psoriasis.Objective:The aim of this review is to report the use and discuss the mechanism of action of cur-cumin in the management of psoriasis and mutually overcome the side effects shown by the synthet-ic medications.Methods:For qualitative literature review PubMed, Scopus, Web of Science, Google Scholar, Google Books, and Science Direct meet the inclusion criteria.Results:Through ample literature surveys, curcumin has been proposed as a safe and therapeutic option for psoriasis as compared to synthetic medications.Conclusion:As traditional herb curcumin appears as a beneficiary medicament because of its anti-oxidant, anti-inflammatory and immune-modulating activities proposing minimal side effects. Thereby ensuring its defensive mechanism against psoriasis.
Biological Importance of Flavonoid Bavachinin in the Medicine:
Perspectives of Medicinal Importance, Pharmacological Activities and
Analytical Techniques
Authors: Patel Kanika , Patel Dinesh Kumar 
Published: April 2022

Backgrounds:
Phytochemicals are an important class of natural compounds present in vegetables, herbs, fruits, and seeds. Phytochemicals have been used in medicine for the treatment of human disorders in the form of drugs, medicine, and Nutraceuticals. Flavonoid class secondary metabolites were found to be present in medicinal plants and some food materials derived from plants. Flavonoid class phytochemicals have beneficial health aspects and numerous pharmacological activities in
the medicine. Psoralea corylifolia has been widely used in medicine for the treatment of skin diseases, including vitiligo, alopecia areata, leukoderma, and psoriasis. More than 90 different types of phytocompounds have been separated and isolated from Psoralea corylifolia. Bavachinin is a flavonoid
class phytochemical, found to be present in the seeds of Psoralea corylifolia. Bavachinin possesses
anti-bacterial, anti-oxidative, anti-inflammatory, α-glucosidase and nitric oxide inhibitory potential.

Method:
Scientific data on bavachinin have been collected from different literature databases such as
Google, Google Scholar, PubMed, Science Direct and Scopus in the present work and analyzed to
know the biological importance of bavachinin. Scientific research data on bavachinin have been collected in the present work for their medicinal importance, pharmacological activities and analytical
aspects. Further, all the collected scientific data have been separated into different sub-sections i.e.,
Medicinal importance, pharmacological activities and analytical aspects of bavachinin. Detailed pharmacological activity data of bavachinin have been analyzed in the present work to know the therapeutic potential of bavachinin in medicine. Analytical data of bavachinin have been collected and analyzed in the present work to know the biological importance of bavachinin in modern medicine for the
standardization of Psoralea corylifolia.

Results:
Literature data analysis of different scientific research works revealed the biological importance of flavonoids in medicine. Flavonoid class phytochemicals have anti-inflammatory, antioxidant, anti-viral, anti-cancer and anti-ageing properties in medicine. Scientific data analysis revealed the effectiveness of bavachinin in cancer, blood glucose, Alzheimer's disease, Parkinson's disease, inflammation, immune system, T cell differentiation, oxidative damage and enzymes. However,
therapeutic efficacy, metabolism, biotransformation, pharmaceutical product development and pharmacokinetic parameters of bavachinin have also been discussed in the present work. Analytical data
signified the importance of modern analytical tools for the separation, isolation and identification of
bavachinin.

Conclusion:
Scientific data analysis of different research work revealed the biological importance and
therapeutic benefit of bavachinin in medicine.
Role of Phytoremediation in Enhancing Heavy Metals Tolerance: A Novel Biotechnological Approach
Authors: Behera Lalita Mohan , Sahoo Saubhagya Subhadarsini , Baral Somanath , Nayak Rabindra , Sahu Abhishek , Dash Rutumbara , Srivastava Ankit , Jit Bimal Prasad , Pradhan Biswajita 
Published: April 2022

Abstract:
Rapid global modernization, urbanization, industrialization, and frequent natural processes
release toxic heavy metals into the environment such as mercury (Hg), lead (Pb), cadmium (Cd),
arsenic (As) and selenium (Se). In the present scenario, soil and water ecosystems are the main environmental
alarms. The remediation of contaminated soils and water ecosystems with appropriate
approaches is urgently needed. Physical remediation strategies are conventional, expensive, and
nonspecific. In contrast, phytoremediation is an eco-friendly and fast-growing approach that is accomplished
due to the high uptake of toxic heavy metals from the environment. Since plants are
slow-growing and have low biomass they urgently need to be bioengineered for high biomass. On
the other hand, biotechnology helps identify and isolate gene coding for heavy metal resistance tolerance
in plants. Moreover, molecular cloning and the manifestation of heavy metal accumulator
genes and other associated genes & enzymes can facilitate the remediation rates, which will make
the process with a large-scale application that will improve the phytoremediation process. This review
highlights the biotechnological methods and strategies for the remediation of heavy metals and
metalloid containment from environments. Furthermore, this review also comprises the improvements
and implications of phytoremediation as well as their operations and applications to reduce
toxic pollutants from environments and to improvise phytoremediation efficiency to tolerate various
heavy metal pollutants highlighting future challenges.
Formulation of Methotrexate Loaded Solid Lipid Nanoparticles By Micro
Emulsion Technique
Authors: Krishnasailaja Abbaraju , Gazi Ayesha Siddiqua 
Published: April 2022

AIM:
The aim of this study was to develop and characterize Methotrexate loaded solid lipid
nanoparticles by Microemulsion technique.

Background:
Methotrexate is a preferable anti metabolite drug. It is used in the treatment of certain
cancers like breast cancer, skin and lung cancer. Clinical studies have revealed that the curative effect
of MTX tablet on cancers was limited due to their toxic dose-related side effects to normal cells, nephrotoxicity,
and bone marrow suppression, acute and chronic hepatotoxicity and also due to the drug
resistance of the tumour cells. Hence, there is a need to develop methotrexate solid lipid nanoparticles
in order to minimize the adverse effects associated with the MTX tablet dosage form.

Objective:
The objective of the research work is to formulate, characterize and evaluate Methotrexate
solid lipid nanoparticles by micro emulsification solidification technique.

Methods:
Solid lipid nanoparticles are prepared by using lipids stearic acid and glycerol monostearate
by varying the concentration of surfactant. Three formulations were prepared with each lipid. Micro
emulsion technique was adopted for the preparation of solid lipid nanoparticles. Each formulation was
evaluated for drug content, entrapment efficiency, loading capacity& invitro drug release studies. Both
the lipids were compared for the characterization and evaluation parameters.

Result:
On comparison Glycerol monostearate was found to be a better lipid over Stearic acid for the
preparation of Methotrexate solid lipid nanoparticles because of its smaller mean particle diameter
(238.8 nm), higher stability (-56.5 mV) and greater entrapment efficiency.

Conclusion:
Methotrexate solid lipid nanoparticles were successfully prepared with higher stability
and drug release rate.
A Method based on Multi-agent Systems and Passive Replication
Technique for Predicting Failures in Cloud Computing
Authors: Hioual Ouided , Hioual Ouassila , Hemam Sofiane Mounine , Maifi Lyes 
Published: April 2022

Background:
Cloud computing refers to the computing capacities of remote
computers, where the user has considerable computing power without having to own power units.
The probability of failures, which can occur during execution, increases in the number of nodes.
Since failures cannot be completely avoided, one solution is to use failure tolerance mechanisms.
Predicting failures has become a major task for engineers and software developers, as failure
increases resource usage costs.

Objectives and Methods:
This paper presents a hybrid method of predicting failures in a cloudcomputing
environment based on the passive replication technique and multi-agent systems. It
detects failures, improves the average response time and minimizes lost time. This method makes
it possible to efficiently and transparently guarantee the continuity of cloud computing services in
the presence of failures.

Results:
The results show that the proposed method performs well in the presence of failures,
improves the response time and minimizes the additional costs caused by the failures.

Conclusion:
This paper proposes a hybrid method of predicting failures in cloud-computing
based on the passive replication technique and multi-agent systems to detect failures and
minimize lost time. The replication technique works by duplicating some system components,
which are deployed simultaneously across different resources. This technique aims to make the
system robust, increase availability and guarantee the execution of jobs. In addition, it is suitable
for long-running tasks.