bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing how information source and trust influence risk perception about Ebola in Ghana and Liberia
Authors: Thompson Esi E 
Published: May 2022

Abstract
The increasing occurrence of diseases across geographical borders creates a need to understand how information source preferences and trust in those sources influence risk perception across contexts. However, cross-context studies about information sources are not common in health communication and promotion scholarship. Using a survey, the research team compared how information sources, perceived usefulness of Ebola information, interpersonal and social trust and context influence risk perception and self-efficacy in an Ebola-affected (Liberia) and -unaffected (Ghana) country. Respondents from the unaffected country trusted the information they received significantly more and had higher levels of interpersonal and social trust than respondents from the affected country. These findings reinforce the use of community health workers as channels to support behavior and social change-focused programs, particularly in crisis situations, in addition to other information channels and sources.
Voluntary actions by the Antarctic krill fishing industry help reduce potential negative impacts on land-based marine predators during breeding, highlighting the need for CCAMLR action
Authors: Godø Olav Rune , Trathan Philip 
Published: May 2022

Abstract
The Commission for the Conservation of Antarctic Marine Living Resources is responsible for management of the Antarctic marine ecosystem, including its living resources. The Commission has yet to implement precautionary measures that protect predators dependent upon Antarctic krill from potential food competition with fisheries where these now increasingly spatially aggregate. Here, we describe voluntary buffer zones (VBZ) implemented in 2018 by the Association of Responsible Krill harvesting companies (ARK) following negotiations with environmental NGOs. The VBZ now prohibit krill fishing during the penguin-breeding season around important penguin colonies along the Antarctic Peninsula. We describe the background of the VBZ and further actions that would ensure ongoing ecological benefits. Lack of data and delays in the implementation of the Commission's revised krill fishery management framework continue to concern NGOs and other stakeholders, especially as part of the management framework will expire in November 2022. Without action by CCAMLR, the ARK VBZ will be the only regulation providing precautionary protection at relevant spatial and temporal scales. The VBZ are an example of how responsible industry can help to protect marine ecosystems when regional management is unable to act given lack of data, and/or associated legal and political constraints.
Categorical Donaldson–Thomas Theory for Local Surfaces: ℤ/2-Periodic Version
Authors: Toda Yukinobu 
Published: May 2022

AbstractWe prove two kinds of $\mathbb {Z}/2$-periodic Koszul duality equivalences for triangulated categories of matrix factorizations associated with $(-1)$-shifted cotangents over quasi-smooth affine derived schemes. We use this result to define $\mathbb {Z}/2$-periodic version of Donaldson–Thomas categories for local surfaces, whose ${\mathbb {C}}^{\ast }$-equivariant version was introduced and developed in the author’s previous paper. We compare $\mathbb {Z}/2$-periodic DT category with the ${\mathbb {C}}^{\ast }$-equivariant one and deduce wall-crossing equivalences of $\mathbb {Z}/2$-periodic DT categories from those of ${\mathbb {C}}^{\ast }$-equivariant DT categories.
Resisting Lockdown: The Influence of COVID-19 Restrictions on Social Unrest
Authors: Wood Reed , Reinhardt Gina Yannitell , RezaeeDaryakenari Babak , Windsor Leah C 
Published: May 2022

AbstractResponding to the COVID-19 pandemic has created unprecedented social and political challenges. Mitigation strategies often disrupt the daily lives of citizens and constrain rights and privileges. Policies intended to contain disease spread have provoked resentment, resistance, and backlash. We examine the extent to which specific COVID-19 policy responses influence the frequency of civil unrest. Combining insights from both grievance and opportunity models of dissent, we contend that pandemic-response policies are most likely to lead to unrest when the grievances and opportunities created by disease-mitigation strategies reinforce each other. We test our arguments with nuanced information on specific pandemic-mitigation policies, combined with geolocated events data on COVID-19-related social unrest activities. We find that policies such as workplace and school closures, which induce intense grievances and reduce the opportunity cost of engaging in collective mobilization, are associated with increases in dissent activities. Policies that restrict opportunities for mobilization, such as restrictions on public transportation, reduce the number of dissent activities. Notably, economic support policies attenuate the effects of workplace closures on dissent. Our results illustrate the varying effects of pandemic-mitigation policies on unrest depending on how the grievances they inspire relate to the opportunity they create.
The multifaceted functions of cGAS
Authors: Liu Haipeng , Wang Fei , Cao Yajuan , Dang Yifang , Ge Baoxue 
Published: May 2022

Abstract
Pattern recognition receptors are critical for the sensing of pathogen-associated molecular patterns or danger-associated molecular patterns and subsequent mounting of innate immunity and shaping of adaptive immunity. The identification of 2′3′-cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS) as a major cytosolic DNA receptor is a milestone in the field of DNA sensing. The engagement of cGAS by double-stranded DNA from different origins, including invading pathogens, damaged mitochondria, ruptured micronuclei, and genomic DNA results in the generation of cGAMP and activation of stimulator of interferon genes, which thereby activates innate immunity mainly characterized by the activation of type I interferon response. In recent years, great progress has been made in understanding the subcellular localization and novel functions of cGAS. In this review, we particularly focus on summarizing the multifaceted roles of cGAS in regulating senescence, autophagy, cell stemness, apoptosis, angiogenesis, cell proliferation, antitumor effect, DNA replication, DNA damage repair, micronucleophagy, as well as cell metabolism.
Improving Patient Advocacy in NCI Scientific Steering Committees and Task Forces
Authors: Bangs Rick , Lynn Jean M , Obot Evelyn , Osborne Sherill , Norris Kim 
Published: May 2022

Abstract
This commentary discusses improving research advocacy as part of National Cancer Institute (NCI) clinical trial activities in scientific steering committees and task forces between 2016 and 2020. Before 2016, the focus of patient advocate input on clinical trial concept evaluation was assessing accrual feasibility. By leveraging informal benchmarking and an outside-in perspective, the NCI patient advocate steering committee, comprised of NCI scientific steering committee and task force advocates, has recalibrated research advocacy within and across its clinical trial concepts. Additionally, by focusing on research advocacy fundamentals, the NCI patient advocate steering committee clarified the scope of the research advocate roles, focused its mission, defined and developed competencies, measured engagement, and created collateral and processes that support better interactions and greater value generation. Continuous improvement in the collateral and the underlying approaches, along with calibrating their application and monitoring results, will be necessary to keep pace with the science and further enhance the value of cancer clinical trial research advocacy. The road ahead should build on these fundamentals and include increased emphasis on diversity, equity, and inclusion in clinical trial and research advocacy participants and the supporting infrastructure.
Persistence of Chemotherapy-Induced Peripheral Neuropathy Despite Vincristine Reduction in Childhood B-Acute Lymphoblastic Leukemia
Authors: Rodwin Rozalyn L , Kairalla John A , Hibbitts Emily , Devidas Meenakshi , Whitley Moira K , Mohrmann Caroline E , Schore Reuven J , Raetz Elizabeth , Winick Naomi J , Hunger Stephen P , Loh Mignon L , Hockenberry Marilyn J , Angiolillo Anne L , Ness Kirsten K , Kadan-Lottick Nina S 
Published: May 2022

AbstractBackgroundChildren with B-acute lymphoblastic leukemia (B-ALL) are at risk for chemotherapy-induced peripheral neuropathy (CIPN). Children’s Oncology Group AALL0932 randomized reduction in vincristine and dexamethasone (every 4 weeks vs 12 weeks during maintenance in the average-risk subset of National Cancer Institute standard-B-ALL (SR AR B-ALL). We longitudinally measured CIPN, overall and by treatment group.MethodsAALL0932 standard-B-ALL patients aged 3 years and older were evaluated at T1-T4 (end consolidation, maintenance month 1, maintenance month 18, 12 months posttherapy). Physical and occupational therapists (PT/OT) measured motor CIPN (hand and ankle strength, dorsiflexion and plantarflexion range of motion), sensory CIPN (finger and toe vibration and touch), function (dexterity [Purdue Pegboard], and walking efficiency [Six-Minute Walk]). Proxy-reported function (Pediatric Outcome Data Collection Instrument) and quality of life (Pediatric Quality of Life Inventory) were assessed. Age- and sex-matched z scores and proportion impaired were measured longitudinally and compared between groups.ResultsConsent and data were obtained from 150 participants (mean age = 5.1 years [SD = 1.7], 48.7% female). Among participants with completed evaluations, 81.8% had CIPN at T1 (74.5% motor, 34.1% sensory). When examining severity of PT/OT outcomes, only handgrip strength (P &lt; .001) and walking efficiency (P = .02) improved from T1-T4, and only dorsiflexion range of motion (46.7% vs 14.7%; P = .008) and handgrip strength (22.2% vs 37.1%; P = .03) differed in vincristine and dexamethasone every 4 weeks vs vincristine and dexamethasone 12 weeks at T4. Proxy-reported outcomes improved from T1 to T4 (P &lt; .001), and most did not differ between groups.ConclusionsCIPN is prevalent early in B-ALL therapy and persists at least 12 months posttherapy. Most outcomes did not differ between treatment groups despite reduction in vincristine frequency. Children with B-ALL should be monitored for CIPN, even with reduced vincristine frequency.
Racial and Ethnic Disparities in Lung Cancer Screening by the 2021 USPSTF Guidelines Versus Risk-Based Criteria: The Multiethnic Cohort Study
Authors: Aredo Jacqueline V , Choi Eunji , Ding Victoria Y , Tammemägi Martin C , ten Haaf Kevin , Luo Sophia J , Freedman Neal D , Wilkens Lynne R , Le Marchand Loïc , Wakelee Heather A , Meza Rafael , Park Sung-Shim Lani , Cheng Iona , Han Summer S 
Published: May 2022

Abstract

Background
In 2021, the US Preventive Services Task Force (USPSTF) revised its lung cancer screening guidelines to expand screening eligibility. We evaluated screening sensitivities and racial and ethnic disparities under the 2021 USPSTF criteria vs alternative risk-based criteria in a racially and ethnically diverse population.

Methods
In the Multiethnic Cohort, we evaluated the proportion of ever-smoking lung cancer cases eligible for screening (ie, screening sensitivity) under the 2021 USPSTF criteria and under risk-based criteria through the PLCOm2012 model (6-year risk ≥1.51%). We also calculated the screening disparity (ie, absolute sensitivity difference) for each of 4 racial or ethnic groups (African American, Japanese American, Latino, Native Hawaiian) vs White cases.

Results
Among 5900 lung cancer cases, 43.3% were screen eligible under the 2021 USPSTF criteria. Screening sensitivities varied by race and ethnicity, with Native Hawaiian (56.7%) and White (49.6%) cases attaining the highest sensitivities and Latino (37.3%), African American (38.4%), and Japanese American (40.0%) cases attaining the lowest. Latino cases had the greatest screening disparity vs White cases at 12.4%, followed by African American (11.2%) and Japanese American (9.6%) cases. Under risk-based screening, the overall screening sensitivity increased to 75.7%, and all racial and ethnic groups had increased sensitivities (54.5%-91.9%). Whereas the screening disparity decreased to 5.1% for African American cases, it increased to 28.6% for Latino cases and 12.8% for Japanese American cases.

Conclusions
In the Multiethnic Cohort, racial and ethnic disparities decreased but persisted under the 2021 USPSTF lung cancer screening guidelines. Risk-based screening through PLCOm2012 may increase screening sensitivities and help to reduce disparities in some, but not all, racial and ethnic groups. Further optimization of risk-based screening strategies across diverse populations is needed.
The Impact of Androgen Deprivation Therapy on COVID-19 Illness in Men With Prostate Cancer
Authors: Shah Neil J , Patel Vaibhav G , Zhong Xiaobo , Pina Luis , Hawley Jessica E , Lin Emily , Gartrell Benjamin A , Febles Victor Adorno , Wise David R , Qin Qian , Mellgard George , Joshi Himanshu , Nauseef Jones T , Green David A , Vlachostergios Panagiotis J , Kwon Daniel H , Huang Franklin , Liaw Bobby , Tagawa Scott , Kantoff Philip , Morris Michael J , Oh William K 
Published: May 2022

Abstract

Background
TMPRSS2, a cell surface protease regulated by androgens and commonly upregulated in prostate cancer (PCa), is a necessary component for SARS-CoV-2 viral entry into respiratory epithelial cells. Previous reports suggested a lower risk of SARS-CoV-2 among PCa patients on androgen deprivation therapy (ADT). However, the impact of ADT on severe COVID-19 illness is poorly understood.

Methods
We performed a multicenter study across 7 US medical centers and evaluated patients with PCa and SARS-CoV-2 detected by polymerase-chain-reaction between March 1, 2020, and May 31, 2020. PCa patients were considered on ADT if they had received appropriate ADT treatment within 6 months of COVID-19 diagnosis. We used multivariable logistic and Cox proportional-hazard regression models for analysis. All statistical tests were 2-sided.

Results
We identified 465 PCa patients (median age = 71 years) with a median follow-up of 60 days. Age, body mass index, cardiovascular comorbidity, and PCa clinical disease state adjusted overall survival (hazard ratio [HR] = 1.16, 95% confidence interval [CI] = 0.68 to 1.98, P = .59), hospitalization status (HR = 0.96, 95% CI = 0.52 to 1.77, P = .90), supplemental oxygenation (HR 1.14, 95% CI = 0.66 to 1.99, P = .64), and use of mechanical ventilation (HR = 0.81, 95% CI = 0.25 to 2.66, P = .73) were similar between ADT and non-ADT cohorts. Similarly, the addition of androgen receptor–directed therapy within 30 days of COVID-19 diagnosis to ADT vs ADT alone did not statistically significantly affect overall survival (androgen receptor–directed therapy: HR = 1.27, 95% CI = 0.69 to 2.32, P = .44).

Conclusions
In this retrospective cohort of PCa patients, the use of ADT was not demonstrated to influence severe COVID-19 outcomes, as defined by hospitalization, supplemental oxygen use, or death. Age 70 years and older was statistically significantly associated with a higher risk of developing severe COVID-19 disease.
Azetidine-2-Carboxylic Acid-Induced Oligodendrogliopathy: Relevance to the Pathogenesis of Multiple Sclerosis
Authors: Sobel Raymond A , Albertelli Megan , Hinojoza Julian R , Eaton Mary Jane , Grimes Kevin V , Rubenstein Edward 
Published: May 2022

Abstract
The naturally occurring imino acid azetidine-2-carboxylic acid (Aze) is consumed by humans and can be misincorporated in place of proline in myelin basic protein (MBP) in vitro. To determine Aze effects on the mammalian CNS in vivo, adult CD1 mice were given Aze orally or intraperitoneally. Clinical signs reminiscent of MBP-mutant mice occurred with 600 mg/kg Aze exposure. Aze induced oligodendrocyte (OL) nucleomegaly and nucleoplasm clearing, dilated endoplasmic reticulum, cytoplasmic vacuolation, abnormal mitochondria, and Aze dose-dependent apoptosis. Immunohistochemistry demonstrated myelin blistering and nuclear translocation of unfolded protein response (UPR)/proinflammatory molecules (ATF3, ATF4, ATF6, eIF2α, GADD153, NFκB, PERK, XBP1), MHC I expression, and MBP cytoplasmic aggregation in OL. There were scattered microglial nodules in CNS white matter (WM); other CNS cells appeared unaffected. Mice given Aze in utero and postnatally showed more marked effects than their dams. These OL, myelin, and microglial alterations are found in normal-appearing WM (NAWM) in multiple sclerosis (MS) patients. Thus, Aze induces a distinct oligodendrogliopathy in mice that recapitulates MS NAWM pathology without leukocyte infiltration. Because myelin proteins are relatively stable throughout life, we hypothesize that Aze misincorporation in myelin proteins during myelinogenesis in humans results in a progressive UPR that may be a primary process in MS pathogenesis.
Spread, Vector Flight Behavior, and Impact of Laurel Wilt in Sassafras Beyond the Gulf-Atlantic Coastal Plain
Authors: Mayfield Albert E , Olatinwo Rabiu O , Hwang Jaesoon , Mudder Bryan T , Blevins Alexandra , Fraedrich Stephen W 
Published: May 2022

Abstract

Laurel wilt is a destructive vascular disease of trees in the laurel family (Lauraceae) caused by a nonnative insect/pathogen complex. This study monitored the recent spread and impact of laurel wilt in sassafras (Sassafras albidum [Nutt.] Nees) from the Gulf-Atlantic Coastal Plain region of the southeastern United States (US) into the adjacent Piedmont/Sandhills and Mountain regions. Laurel wilt was detected at thirteen of forty-six sassafras sites including seven outside the Coastal Plain. Compared to nondiseased sites, sassafras mortality due to laurel wilt increased rapidly from 2018 to 2020 and occurred in all diameter classes monitored (≥ 5 cm diameter at breast height, dbh). Flight trapping for the laurel wilt vector, the redbay ambrosia beetle (RAB, Xyleborus glabratus Eichhoff), with α-copaene lures did not enhance early detection of latent laurel wilt infections. Seasonal flight activity of the RAB in the Piedmont and Mountains suggested two generations per year with little to no flight from December through March.

Study Implications
Sassafras is the most widely-distributed lauraceous tree species in the US and is valued for its ecological functions, durable wood, and numerous cultural uses. Our results strongly suggest the potential for substantial loss of the existing sassafras resource as laurel wilt continues spreading through the eastern US. Survey traps baited with current lures for the primary insect vector are unlikely to improve early detection of new laurel wilt infections. The georeferenced network of plots established for this project provides baseline data for future monitoring efforts and could be revisited to look for evidence of sassafras resistance to the laurel wilt pathogen.
Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations
Authors: Xiong Qing , Wan Angel Tsz-Yau , Liu Xiaoyu , Fung Cathy Sin-Hang , Xiao Xiaojun , Malainual Nat , Hou Jinpao , Wang Lingyi , Wang Mingqiang , Yang Kevin Yi , Cui Yubao , Leung Elaine Lai-Han , Nong Wenyan , Shin Soo-Kyung , Au Shannon Wing-Ngor , Jeong Kyoung Yong , Chew Fook-Tim , Hui Jerome Ho-Lam , Leung Ting-Fan , Tungtrongchitr Anchalee , Zhong Nanshan , Liu Zhigang , Tsui Stephen Kwok-Wing 
Published: May 2022

Abstract
Highly diversified astigmatic mites comprise many medically important human household pests such as house dust mites causing ∼1–2% of all allergic diseases globally; however, their evolutionary origin and diverse lifestyles including reversible parasitism have not been illustrated at the genomic level, which hampers allergy prevention and our exploration of these household pests. Using six high-quality assembled and annotated genomes, this study not only refuted the monophyly of mites and ticks, but also thoroughly explored the divergence of Acariformes and the diversification of astigmatic mites. In monophyletic Acariformes, Prostigmata known as notorious plant pests first evolved, and then rapidly evolving Astigmata diverged from soil oribatid mites. Within astigmatic mites, a wide range of gene families rapidly expanded via tandem gene duplications, including ionotropic glutamate receptors, triacylglycerol lipases, serine proteases and UDP glucuronosyltransferases. Gene diversification after tandem duplications provides many genetic resources for adaptation to sensing environmental signals, digestion, and detoxification in rapidly changing household environments. Many gene decay events only occurred in the skin-burrowing parasitic mite Sarcoptes scabiei. Throughout the evolution of Acariformes, massive horizontal gene transfer events occurred in gene families such as UDP glucuronosyltransferases and several important fungal cell wall lytic enzymes, which enable detoxification and digestive functions and provide perfect drug targets for pest control. This comparative study sheds light on the divergent evolution and quick adaptation to human household environments of astigmatic mites and provides insights into the genetic adaptations and even control of human household pests.
Refractory satellite ganglion cyst in the hallux and finger
Authors: Muramatsu Keiichi , Tani Yasuhiro , Kobayashi Masato , Sugimoto Hideaki , Iwanaga Ryuta , Mihara Atsushi , Sakai Koji 
Published: May 2022

ABSTRACTPainful ganglion cysts that develop in the hallux and finger usually enlarge progressively to the peripheral direction. Simple resection of satellite ganglion cyst alone has been reported to cause a high rate of recurrence and treatment is often very difficult. The purpose of this study is to evaluate the appropriate surgical treatment for painful satellite ganglion cysts in the hallux and finger and discuss the origin of the ganglion cysts in cases treated surgically at our hospital. We reviewed five cases (three males and two females, ages 55–87 years), three of which occurred in the hallux and two in the finger. In all cases, the preoperative magnetic resonance image showed a large fluid of the flexor tendon sheath. And also, joint effusion was found in the metatarsophalangeal joint and the proximal interphalangeal joint. The first case of the hallux ganglion underwent simple excision of the cyst and had recurrences three times. In the other four cases, the additional synovectomy of the metatarsophalangeal joint and the proximal interphalangeal joint was performed along with ganglion cyst excision. These cases had no recurrence up to 1 year after operation. Recently, there have been reports that tendon sheath ganglions are connected to the ankle, wrist, hallux, and phalangeal joints. Although there are a few cases in our department, satellite ganglion cyst of the hallux and finger possibly originates from adjacent joints. Additional synovectomy of the affected joint should be performed for the excision of satellite ganglion cyst to prevent recurrence.