bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aplikasi Gofutsal Untuk Pemesanan Lapangan Futsal Berbasis Android
Authors: Kristanto Bagus Kristomoyo , Yosep Erikson Paulus , Sijabat Daniel Rudiaman 
Published: March 2022

Futsal saat ini menjadi salah satu cabang olahraga yang banyak diminati oleh berbagai kalangan usia di Indonesia, termasuk di Kota Malang. Dengan berkembangnya olahraga futsal ini juga berdampak positif pada pelaku bisnis, banyak yang memanfaatkan kondisi ini untuk membuka lahan bisnis salah satunya membuat lapangan futsal untuk disewakan. Para penyedia jasa sewa lapangan futsal berlomba-lomba untuk menarik peminat dengan berbagai fasilitas yang ditawarkan. Namun itu semua tidak didukung dengan sarana yang baik dalam menyampaikan informasi. Proses penyewaan juga cukup merepotkan masyarakat dengan adanya kendala-kendala yang sering ditemui. Pemesan harus datang secara langsung untuk melihat ketersediaan jadwal, hal ini dapat memakan waktu yang cukup lama. Pada penelitian ini, akan dirancang sebuah aplikasi GoFutsal berbasis android. Pembuatan aplikasi GoFutsal ini menggunakan cara pengumpulan data, analisis permasalahan dan perancangan perangkat lunak disertai pengujian terhadap perangkat lunaknya. Hasil dari penelitian ini berupa aplikasi pemesanan lapangan futsal yang dapat diakses melalui platform android. Hasil uji coba Black Box yang dilakukan terhadap fitur-fitur aplikasi Gofutsal ini berjalan dengan baik dan sesuai dengan fungsinya. Dengan adanya aplikasi GoFutsal ini diharapkan dapat membantu masyarakat dalam mendapatkan informasi serta bisa mempermudah proses pemesanan lapangan futsal.
Kata Kunci : Futsal, Lapangan Futsal, Aplikasi Android, Black Box
Challenges in Translating Arabic Culture-Bound Words into English: The Case of Selected Plays of the Egyptian Playwright Noaman Ashour
Authors: Gomaa Yasser , Nour El Din Amr 
Published: March 2022

This study attempts to demonstrate the mediating role the translator is entrusted with and the efforts undertaken by him/her to transcend cultural barriers. Two plays written by the renowned Egyptian dramatist Noamaan Ashour feature high on this study because they are heavily laden with culture-bound expressions that mirror the Egyptian cultural milieu. Also, the study explores the strategies formulated by the translator to address the problem of culture-bound items. These items pose a challenge to the translator since they are so deeply embedded in the source culture that the translator may find it difficult to render them into the Target Language (TL). Each translation strategy has its merits and demerits: cultural substitution is a reasonable strategy, but it entails that the translator should carefully consider equivalents and the hierarchy of correspondences so as to adapt the values of the Source Language (SL) cultural system to the values of the TL cultural system. Translation by paraphrase is another viable strategy, but it is sometimes cumbersome for the translator to break up a lexical item into several words and cover all its shades of meaning. The option of paraphrase may reduce the degree of transparency in Target Text (TT) since the addition of a paraphrase alerts the TL readers that the lexical item in question does not exist in their cultural matrix. Further, the strategy of cultural borrowing entails carrying across the meaning of cultural specifics verbatim into the TT. It thus involves the insertion of footnotes having explanatory material, and transliteration. This strategy may break the flow of thoughts of the TL readers since they will have to consult the footnotes while reading. Besides, the translator may run the risk of producing an inadequate definition of the culture-specific item in the footnote. Translation by omission is given due attention in this research as a strategy conducive to creating a smooth and readable Target Text. Translators should pay heed to the fact that this strategy is not a pretext to evade complex and awkward words and expressions; rather this strategy is justifiably adopted to prevent any degree of miscomprehension on the part of the TL readers. The strategy of compensation is demonstrated in this study. Translators are recommended to heed it since it seeks to create an understandable imitation of the Source Text.
Seasonal Pattern of Hand Foot and Mouth Disease in an Out-patient Clinic of a Tertiary Care Pediatric Hospital at Dhaka
Authors: Hussain Mahfuza , Amin Md Nurul , Islam Md Rafiqul 
Published: March 2022

Background & Objective: Hand, foot and mouth disease (HFMD) is a contagious disease of children, occurs primarily under five years of age, characterized by a history of brief febrile illness and a typical skin rash over hands and feet with or without sores in mouth, caused usually by Coxsackievirus A16 viruses. It is mainly the disease of tropical and subtropical countries and bears a complex-relation with meteorological variables, like temperature, rainfall and relative humidity, although no study has yet been done in Bangladesh to explain the complex relationship of the disease with these variables. This study sought to describe the occurrence of HFMD and its association with meteorological factors in Dhaka city.
Methods: The present cross-sectional study collected data of 231 HFMD cases from the records of the daily register of Out-patient Department of Dhaka Shisu Hospital, Dhaka between January 2018 to December 2019. According to the study protocol a child was identified as having HFMD who had a history of brief febrile illness accompanied by a typical skin rash with or without mouth ulcers. Total number of cases treated monthly at OPD during the period were also recorded. Meteorological data were provided by Bangladesh Meteorological Department, which among others, included monthly average temperature, relative humidity and amount of rainfall. While the outcome variable was monthly number of HFMD cases, the predictive variables were average temperature, humidity and rainfall during the study period.
Result: Majority (85.3%) children in the present study was < 5 years old. A male preponderance was observed in the series (60%) with male to ratio being 3:2. A clustering of HFMD cases was observed to occur between June to October when monthly average temperature, total rainfall and humidity all were at their maximum compared to those found between November to April. The clustering of cases was more intense in the year 2019 than that in the year 2018. During the period average monthly temperature was 29.20C, average rainfall was 62.6% (238 mm) of the total annual precipitation and mean relative humidity was 79%. The proportion of HFMD cases out of total cases treated during the period was 2.2% in 2018 and was 4.1% in 2019, which in the dry season (November to April) was 0.4% and 0.5% in 2018 and 2019 respectively.
Conclusion: The study concluded that majority of the HFMD cases occur under five years of age and boys are more likely to have the infection than the girls. A seasonality of HFMD occurrence is observed with a higher number of cases occurring in the monsoon season and fewer cases in the dry season. Clustering of HFMD cases occur between May to October when monthly average temperature, total rainfall and humidity all are at peak compared to those in November to April of the year.
Ibrahim Card Med J 2021; 11 (1): 14-20
Pengembangan Lembar Kerja Peserta Didik (LKPD) Berbasis Value Clarification Technique (VCT) Untuk Menanamkan Nilai Karakter Cinta Tanah Air
Authors: Yuliarni Nini , Djuwita Puspa , Hambali Daimun 
Published: March 2022

Penelitian ini mengemabanga bahan ajar berupa LKPD yang terintegrasi dengan penanaman nilai. Selama ini penanaman nilai hanya sekedar formalitas diawal pembelajaran tanpa diintegrasikan ke dalam proses pembelajaran. Pengemabangan LKPD ini bertuan untuk mendeskripsiakn pengemabangan LKPD, kelayakan LKPD, dan kepraktisan LKPD.LKPD berbasis VCT ini dikembangkan dengan model BORG & GALL sebanyak 10 langkah. Akan tetapi pada penelitian ini hanya 6 langkah yang dipakai karena pada saat penelitian ini sedang terjadi pandemi covid 19, yang membaut pemerinta mengeluarkan kebijakan tidak boleh melakukan tatap muka dalam jumlah yang banyak. Adapun langkah-langkah pengembangan ini yaitu : potensi dan masalah, pengumpulan data, desain produk, validasi produk, revisi produk, dan ujicoba terbatas. Untuk melihat kelayakan LKPD dilakukan validasi oleh 12 validator yang setelah diperoelh skor dianalisis dengan formula Aiken's V. Dari hasil analisis diperoleh rata-rata validasi sangat valid yang berarti LKPD ini sangat layak untuk dipergunakan tetapi tetap harus melakukan revisi berdasrkan masukan dari para ahli. Untuk melihat kepraktisan LKPD dilakukan ujicoba terbatas terhadap 4 orang guru dan 10o orang siswa SDN 81 Kota Bengkulu. Dari hasil analisis angket respon guru dan angket respon siswa diperoleh rata-rata persentase sangat praktis untuk dipergunakan terhadap produk LKPD.
Pengembangan Lembar Kerja Peserta Didik (LKPD) Berbasis Nilai-Nilai Karakter Dasa Darma Pramuka pada Pembelajaran PPKn Kelas V SDN 72 Bengkulu Tengah
Authors: Hendriwati Hendriwati , Djuwita Puspa , Hambali Daimun 
Published: March 2022

Abstract This research is motivated by a decrease in the character values of students and the absence of a LKPD that contains the character values of Dasa Darma Pramuka at SDN 72 Bengkulu Tengah. This affects the achievement of learning objectives, namely forming students with character. This study aims to determine the validity and practicality of LKPD based on the values of Dasa Darma Pramuka. This research is a development research using the 4- D model which consists of four stages, namely define, design, develop and disseminate. This research was only conducted until the develop stage, namely the validity test and practicality test. The instrument used was a validity test questionnaire and a practicality test questionnaire. The validity test was carried out by 6 validators, namely 2 material experts, 2 linguists and 2 graphic experts. The practicality test was carried out on 19 students of SDN 72 Bengkulu Tengah. Data from the validity and practicality test results were analyzed by using percentage techniques and processed descriptively. The results of the LKPD validity test based on the values of Dasa Darma by the validator in terms of aspects of the front page, table of contents, study instructions, material feasibility, language presentation, and graphic feasibility, material eligibility was obtained 0.81 with proper criteria, language eligibility results 0, 75 with very feasible criteria and a graphical feasibility result of 0.81. The practicality test results of the LKPD based on the values of the Dasa Darma Pramuka, obtained a value of 80.69 by the teacher and 80.95 by students with practical criteria. Based on the results of the study it can be concluded that the use of LKPD values of Dasa Darma Pramuka SDN 72 Bengkulu Tengah in grade V is very feasible and very practical.Keywords : Dasa Darma, Character, student worksheet
The MDM2 Single-Nucleotide Polymorphism T309G Is Associated With the Development of Epimacular Membranes
Authors: Jiang Heng , Yan Bin , Meng Zhishang , Zhang Lusi , Lei Hetian , Luo Jing 
Published: March 2022

Purpose: To investigate the role of the mouse double minute 2 (MDM2) gene single-nucleotide polymorphism (SNP) T309G in the development of epimacular membranes (EMMs) by analyzing the genotype distribution and consistency of the polymorphism in paired membrane-blood samples.Methods: This was a cross–sectional genetic association study of patients with proliferative vitreoretinopathy (PVR) or EMMs. PVR membranes (PVRMs), internal limiting membranes (ILMs) (PVR-ILMs) and blood samples (PVR-blood) from patients with PVR, and EMMs, EMM-ILMs and EMM-blood from patients with EMMs were collected. The genotype of all samples was determined by Sanger sequencing. Sex composition, mean age, the genotype distribution of MDM2 T309G, the allelic frequency of the MDM2 SNP309 G allele (% G) and the somatic mutation rate at the MDM2 T309G locus (% M) were analyzed and compared. The PVR and healthy Chinese donor groups were used as controls for different comparisons.Results: The EMM group of 62 patients was older than the PVR group of 61 patients by an average of 8.87 years (p &lt; 0.0001), but the two groups were statistically similar in the sex composition (p = 0.1754). Importantly, G allele carriers were at a higher risk of developing EMMs than non-G allele carriers (p = 0.0479; OR = 2.047). Moreover, EMM-blood exhibited a significantly higher % G than blood samples from healthy Chinese donors (EMM-blood: 56.78%, donors: 45.61%; p = 0.0256; OR = 1.567). Regarding membrane-blood consistency, % M was significantly different between PVRMs and EMMs (PVRMs: 2.63%, EMMs: 21.57%; p = 0.0097; OR = 10.18) but not between different types of ILMs (PVR-ILMs: 18.18%, EMM-ILMs: 29.17%; p = 0.6855). Furthermore, EMMs (p = 0.0053; OR = 8.250) and EMM-ILMs (p = 0.0233; OR = 14.40) from patients with preoperative macular holes were more predisposed toward somatic mutations at the MDM2 T309G locus than those from patients without preoperative macular holes.Conclusions:MDM2 T309G is associated with the development of EMMs. Herein, the MDM2 SNP309 G allele is first reported as an associated factor of EMMs in a Chinese population. In addition, EMMs and ILMs are genetically unstable at the MDM2 T309G locus, especially when complicated with preoperative macular holes.
NanoSIMS Analysis of Rare Earth Elements in Silicate Glass and Zircon: Implications for Partition Coefficients
Authors: Shi Lanlan , Sano Yuji , Takahata Naoto , Koike Mizuho , Morita Takuya , Koyama Yuta , Kagoshima Takanori , Li Yuan , Xu Sheng , Liu Congqiang 
Published: March 2022

We have developed a method to analyze all rare earth elements in silicate glasses and zircon minerals using a high lateral resolution secondary ion mass spectrometer (NanoSIMS). A 2nA O− primary beam was used to sputter a 7–8-μm diameter crater on the sample surface, and secondary positive ions were extracted for mass analysis using an accelerating voltage of 8 kV. A high mass resolving power of 9,400 at 10% peak height was attained to separate heavy REE from oxide of light REE. A multi-collector system combined with peak-jumping by magnetic field was adjusted to detect REEs and silicon-30 for calibration. Based on results of NIST SRM610 glass, sensitivities of REEs vary from 3 cps/ppm/nA of Lu to 13 cps/ppm/nA of Eu. Reproducibility of REE/Si ratios is better than 18% at 2σ. Secondary ion yields of REEs show positive relationships with their ionization potential of second valence. REEs of AS3, QGNG, and Torihama zircons were measured and calibrated against those of 91500 standard zircon. SIYs of REEs of zircon are identical to those of the glass standard. AS3 and QGNG data are generally consistent with those of previous work. Torihama REE data combined with the whole rock data provide partition coefficients of REEs between silicate melt and zircon. The relationship between these coefficients and ionic radius is explained by an elastic moduli model.
Association Between Gut Dysbiosis and Sepsis-Induced Myocardial Dysfunction in Patients With Sepsis or Septic Shock
Authors: Chen Yu , Zhang Fu , Ye Xin , Hu Jing-Juan , Yang Xiao , Yao Lin , Zhao Bing-Cheng , Deng Fan , Liu Ke-Xuan 
Published: March 2022

ObjectiveSepsis-induced myocardial dysfunction (SIMD) seriously affects the evolution and prognosis of the sepsis patient. The gut microbiota has been confirmed to play an important role in sepsis or cardiovascular diseases, but the changes and roles of the gut microbiota in SIMD have not been reported yet. This study aims to assess the compositions of the gut microbiota in sepsis or septic patients with or without myocardial injury and to find the relationship between the gut microbiota and SIMD.MethodsThe prospective, observational, and 1:1 matched case–control study was conducted to observe gut microbiota profiles from patients with SIMD (n = 18) and matched non-SIMD (NSIMD) patients (n = 18) by 16S rRNA gene sequencing. Then the relationship between the relative abundance of microbial taxa and clinical indicators and clinical outcomes related to SIMD was analyzed. The receiver operating characteristic (ROC) curves were used to evaluate the predictive efficiencies of the varied gut microbiota to SIMD.ResultsSIMD was associated with poor outcomes in sepsis patients. The beta-diversity of the gut microbiota was significantly different between the SIMD patients and NSIMD subjects. The gut microbiota profiles in different levels significantly differed between the two groups. Additionally, the abundance of some microbes (Klebsiella variicola, Enterobacteriaceae, and Bacteroides vulgatus) was correlated with clinical indicators and clinical outcomes. Notably, ROC analysis indicated that K. variicola may be a potential biomarker of SIMD.ConclusionOur study indicates that SIMD patients may have a particular gut microbiota signature and that the gut microbiota might be a potential diagnostic marker for evaluating the risk of developing SIMD.
Comparison of the Characteristics, Management, and Outcomes of STEMI Patients Presenting With vs. Those of Patients Presenting Without COVID-19 Infection: A Systematic Review and Meta-Analysis
Authors: Wang Yanjiao , Kang Linlin , Chien Ching-Wen , Xu Jiawen , You Peng , Xing Sizhong , Tung Tao-Hsin 
Published: March 2022

ObjectivesThis study aimed to investigate the differences in the characteristics, management, and clinical outcomes of patients with and that of those without coronavirus disease 2019 (COVID-19) infection who had ST-segment elevation myocardial infarction (STEMI).MethodsDatabases including Web of Science, PubMed, Cochrane Library, and Embase were searched up to July 2021. Observational studies that reported on the characteristics, management, or clinical outcomes and those published as full-text articles were included. The Newcastle-Ottawa Scale (NOS) was used to assess the quality of all included studies.ResultsA total of 27,742 patients from 13 studies were included in this meta-analysis. Significant delay in symptom onset to first medical contact (SO-to-FMC) time (mean difference = 23.42 min; 95% CI: 5.85–40.99 min; p = 0.009) and door-to-balloon (D2B) time (mean difference = 12.27 min; 95% CI: 5.77–18.78 min; p = 0.0002) was observed in COVID-19 patients. Compared to COVID-19 negative patients, those who are positive patients had significantly higher levels of C-reactive protein, D-dimer, and thrombus grade (p &lt; 0.05) and showed more frequent use of thrombus aspiration and glycoprotein IIbIIIa (Gp2b3a) inhibitor (p &lt; 0.05). COVID-19 positive patients also had higher rates of in-hospital mortality (OR = 5.98, 95% CI: 4.78–7.48, p &lt; 0.0001), cardiogenic shock (OR = 2.75, 95% CI: 2.02–3.76, p &lt; 0.0001), and stent thrombosis (OR = 5.65, 95% CI: 2.41–13.23, p &lt; 0.0001). They were also more likely to be admitted to the intensive care unit (ICU) (OR = 4.26, 95% CI: 2.51–7.22, p &lt; 0.0001) and had a longer length of stay (mean difference = 4.63 days; 95% CI: 2.56–6.69 days; p &lt; 0.0001).ConclusionsThis study revealed that COVID-19 infection had an impact on the time of initial medical intervention for patients with STEMI after symptom onset and showed that COVID-19 patients with STEMI were more likely to have thrombosis and had poorer outcomes.
Sustained Downregulation of Vascular Smooth Muscle Acta2 After Transient Angiotensin II Infusion: A New Model of “Vascular Memory”
Authors: Pothen Lucie , Verdoy Roxane , De Mulder Delphine , Esfahani Hrag , Farah Charlotte , Michel Lauriane Y. M. , Dei Zotti Flavia , Bearzatto Bertrand , Ambroise Jerome , Bouzin Caroline , Dessy Chantal , Balligand Jean-Luc 
Published: March 2022

BackgroundActivation of the renin-angiotensin-aldosterone system (RAAS) plays a critical role in the development of hypertension. Published evidence on a putative “memory effect” of AngII on the vascular components is however scarce.AimTo evaluate the long-term effects of transient exposure to AngII on the mouse heart and the arterial tissue.MethodsBlood pressure, cardiovascular tissue damage and remodeling, and systemic oxidative stress were evaluated in C57/B6/J mice at the end of a 2-week AngII infusion (AngII); 2 and 3 weeks after the interruption of a 2-week AngII treatment (AngII+2W and AngII +3W; so-called “memory” conditions) and control littermate (CTRL). RNAseq profiling of aortic tissues was used to identify potential key regulated genes accounting for legacy effects on the vascular phenotype. RNAseq results were validated by RT-qPCR and immunohistochemistry in a reproduction cohort of mice. Key findings were reproduced in a homotypic cell culture model.ResultsThe 2 weeks AngII infusion induced cardiac hypertrophy and aortic damage that persisted beyond AngII interruption and despite blood pressure normalization, with a sustained vascular expression of ICAM1, infiltration by CD45+ cells, and cell proliferation associated with systemic oxidative stress. RNAseq profiling in aortic tissue identified robust Acta2 downregulation at transcript and protein levels (α-smooth muscle actin) that was maintained beyond interruption of AngII treatment. Among regulators of Acta2 expression, the transcription factor Myocardin (Myocd), exhibited a similar expression pattern. The sustained downregulation of Acta2 and Myocd was associated with an increase in H3K27me3 in nuclei of aortic sections from mice in the “memory” conditions. A sustained downregulation of ACTA2 and MYOCD was reproduced in the cultured human aortic vascular smooth muscle cells upon transient exposure to Ang II.ConclusionA transient exposure to Ang II produces prolonged vascular remodeling with robust ACTA2 downregulation, associated with epigenetic imprinting supporting a “memory” effect despite stimulus withdrawal.