bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coronary stent-graft use to salvage a juxta-anastomotic arterial rupture complicating a case of radio-cephalic fistuloplasty
Authors: Lin Zhiyuan , Kallam Neha , Khurram Ruhaid , Al Midani Ammar , Khalifa Mohamed 
Published: August 2022

Abstract
Background
Stenosis is a common complication of haemodialysis arteriovenous accesses. Endovascular approaches with percutaneous transluminal fistuloplasty have largely replaced open surgical approaches as first line treatment. Vessel rupture is an uncommon complication of fistuloplasty and most reports describe venous rupture. Stent-graft deployment can salvage this, however, its use requires careful assessment of the distal vasculature. Arterial rupture with fistuloplasty has rarely been described in the literature. This is a novel case describing the use of a BeGraft coronary stent-graft to manage juxta-anastomotic arterial rupture and pseudoaneurysm complicating fistuloplasty.

Case presentation
A 77 year old female with end stage renal failure secondary to systemic amyloid light chain type amyloidosis was referred for a suspected radio-cephalic arteriovenous fistula stenosis after difficulty cannulating with poor flow during dialysis and clinical reduction in the fistula thrill. Both Doppler ultrasound and intravenous fistulography confirmed a venous stenosis 2 cm distal to the anastomosis. The stenosis was treated by fistuloplasty, however, this was complicated by a rupture of the juxta-anastomotic arterial segment intraoperatively. Intermittent balloon tamponade was used to minimise extravasation although a pseudoaneurysm formed within the damaged arterial segment. The patient’s distal neurovascular status was assessed using the Barbeau test and we sonographically confirmed adequate retrograde arterial flow via a complete palmar arch directing blood from the ulnar artery. After discussion with the renal transplant team, a 4 mm BeGraft coronary stent-graft was deployed to control haemorrhage and bypass the pseudoaneurysm until adequate haemostasis and fistula flow was achieved. Follow-up 3 months post-procedure reported the patient continued with haemodialysis using the stented fistula with no further complications.

Conclusions
To our knowledge, this is the first case report describing the application of BeGraft coronary stent-grafts to salvage fistuloplasty of a radio-cephalic arteriovenous fistula stenosis complicated by juxta-anastomotic arterial rupture and pseudoaneurysm formation. We demonstrate the safety and short-term efficacy of this technology.
Functional non-glutaraldehyde treated porcine pericardium for anti-coagulation, anti-calcification, and endothelial proliferation bioprosthetic heart valves
Authors: Chen Xiaotong , Yu Tao , Kong Qunshou , Kuang Dajun , Xu Hong , Zhao Zhiyu , Yang Li , Li Gaocan , Fan Haojun , Wang Yunbing 
Published: August 2022

AbstractIn the last decade, the number of transcatheter heart valve replacement for severe heart valve disease has increased exponentially. Although the bioprosthetic artificial heart valve (BHV) has similar fluid dynamics performance to the original heart valve compared with mechanical heart valve so that there is no need to take long-term anticoagulant drugs to prevent thromboembolism, transcatheter BHV replacement are still at risk for thrombosis during the first few months according to the clinical data. However, the use of antithrombotic drugs can also increase the risk of bleeding. Therefore, it is particularly important to improve the anticoagulant properties for the BHV itself. In this work, a kind of non-glutaraldehyde cross-linked BHV material with excellent antithrombotic ability has been prepared from carboxylated oxazolidine treated porcine pericardium (consisting of collagen, elastin and glycoprotein) with the further graft of the anticoagulant heparin sodium via hydrophilic modified chitosan. Along with the similar mechanical properties and collagen stability comparable to the glutaraldehyde cross-linked porcine pericardium (PP), these functional non-glutaraldehyde cross-linked PPs exhibit better biocompatibility, promoted endothelial proliferation and superior anti-calcification ability. More importantly, excellent anticoagulant activity can be observed in the hematological experiments in vivo and in vitro. In summary, these excellent performances make these functional non-glutaraldehyde cross-linked PPs great potentialities in the BHV applications.
Graphical abstract
Usefulness of the SAF score to characterize NAFLD/NASH in non-cirrhotic HCV patients
Authors: El Ray Ahmed , Paradis Valerie , Montasser Ahmed , Elghannam Maged , Shemis Mohamed , Nessim Iris , Abu-Taleb Hoda , Asselah Tarik , Mohamed Ashiq , Poté Nicolas , Akl Maha , Marcellin Patrick 
Published: August 2022

Abstract
Background
The SAF score (steatosis, activity, and fibrosis) has been developed for the assessment of the histological severity of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). The aim of this study was to assess the usefulness of the SAF score in a homogenous cohort of Egyptian patients with chronic HCV infection (CHC) without any alcohol consumption and without cirrhosis. We performed a prospective cross-sectional study including 70 consecutive Egyptian patients with chronic HCV infection to assess the usefulness of the SAF score to characterize NAFLD/NASH in non-cirrhotic HCV patients. The inclusion criteria included positive serum anti-HCV IgG antibody and positive HCVRNA, absence of treatment, and absence of cirrhosis (fibrosis score < F4). Patients were divided into two groups: with metabolic syndrome (MS) and without metabolic syndrome (non-MS). All patients were exposed to thorough history taking, full clinical examination, and laboratory and ultrasound assessment. Histopathologic evaluation of the liver biopsy for the assessment of steatosis, activity, grade, and fibrosis stage was assessed by 2 pathologists with experience in liver diseases.

Results
We found that the degree of fibrosis increases with aging. Liver biopsies from CHC patients with metabolic syndrome (MS) exhibited a significantly higher stage of fibrosis than biopsies from those without MS; however, the grade of inflammation did not differ significantly between the two groups. No significant correlation was found between the SAF score and the body mass index (BMI) or serum HCV RNA. No significant relation between SAF score, fibrosis, and MS. No significant relation was found between the MS and the level of HCV viremia.

Conclusion
We concluded that steatosis was associated with the fibrosis stage, independently of MS. This suggests that in this population, steatosis might be more related to HCV infection than to NAFLD and that fibrosis progression might be related, at least in part, to the steatosis process, i.e., virus-associated fatty liver disease (VAFLD).
Comparison of carotid intima media thickness between women with history of preeclampsia and normal pregnancy: a meta-analysis of systematic review
Authors: Pikir Budi Susetyo , Subagjo Agus , Wardhani Deasy Eka , Andrianto  , Oktaviono Yudi Her , Nugraha Ricardo Adrian 
Published: August 2022

Abstract
Background
On a clinical level, preeclampsia and atherosclerotic cardiovascular disease share common risk factors. Carotid intima media thickness (CIMT) is ultrasound-based imaging, non-invasive, simple, and reproducible method of subclinical atherosclerosis evaluation. Nowadays, there were studies concerning of CIMT among preeclamptic women, although the results were different.

Objective
To prove that CIMT among women with histories of preeclampsia was greater compared to normal pregnancy.

Methods
We conducted a meta-analysis of studies that reported CIMT, in women who had preeclampsia and had normal pregnancy. Studies were identified through three databases: PubMed, Google Scholar, and SAGE Journals with publication year of 2010–2020. Heterogeneity was assessed using the I2 statistic. Standardized mean difference was used as measured of effect size.

Results
Nine eligible studies were included in the meta-analysis. This meta-analysis consisted of 439 women with preeclampsia histories and 526 women with normal pregnancy histories. Women who had preeclampsia had significantly higher CIMT compared to those with normal pregnancy with standardized mean difference −0.38 and 95% confidence interval (CI) −0.68 to −0.07 (p=0.02).

Conclusion
CIMT was greater among women with histories of preeclampsia compared to normal pregnancy.

Trial registration
PROSPERO CRD42021228825
A comparative analysis of canal wall reconstruction mastoidectomy over canal wall down mastoidectomy
Authors: Roy Rikta , Gupta Yamini , Roy Pronab Kumar 
Published: August 2022

Abstract
Aim
This study aims to investigate the advantages of canal wall reconstruction mastoidectomy (C.W.R.) over the canal wall down (CWD) mastoidectomy.

Material and method
A prospective study was conducted on sixty patients with cholesteatoma who underwent operation from September 2010 to October 2016. Patients were divided into two groups: “Group A," posterior canal wall reconstruction group (C.W.R.) with 28 patients (28 ears) and “Group B” which included 32 patients (32 ears) in whom canal wall down mastoidectomy (CWD) was done without reconstruction. The patients were followed up at 3 months and 6 months postoperatively with otoendoscopy to look for recurrence or residual disease, the occurrence of any complications, and for hearing assessment.

Results
Group A (C.W.R.) patients were cosmetically better, and none had postoperative cavity problems. While in Group B (CWD), 16 patients (50%) had a cavity problem. Group A CWR group also had early epithelization. Both methods had hearing improvement postoperatively. Group A had more hearing improvement than Group B.

Conclusion
The C.W.R. method is a safe method for eliminating the problem of the mastoid cavity. This surgery can be easily taught and applied universally in all cholesteatoma patients as a primary treatment. The C.W.R. technique provides improved exposure to the middle ear without creating a mastoid bowl, which significantly reduces the incidence of residual and recurrent disease. These results indicate that the C.W.R. method is better than the CWD operation.
Massive ganglioneuroma of the parapharyngeal space in a pediatric patient: a case report
Authors: Jayavelu Swetha , Anderson Raleigh , Low Garren , Asi Karim , Roy Soham 
Published: August 2022

Abstract
Background
Neuroblastic tumors arise from primitive sympathetic ganglion cells and are the most common extracranial solid tumor of childhood. Ganglioneuroma is the most well-differentiated, benign subtype and comprises less than 1% of all soft tissue tumors. One to 5% of these occur in the head and neck, including the parapharyngeal space. It is uncommon to find a physically detectable, neoplastic parapharyngeal space mass in a child.

Case report
A 7-year-old boy presented with a painless left neck mass. Imaging revealed a 2.6 × 2.7 × 6.1 cm left parapharyngeal space mass. Fine-needle aspiration suggested a ganglioneuroma. The patient developed compressive symptoms, notably pain, thus the decision was made to surgically resect. The tumor was excised transcervically, preserving the great vessels, phrenic and cranial nerves. Postoperatively, the patient developed a mild ipsilateral Horner’s syndrome, suggesting the mass to be a ganglioneuroma of the sympathetic chain.

Conclusions
Cervical ganglioneuromas typically present as slow-growing masses that cause compressive symptoms or are found incidentally. Resection is reserved for those with significant symptoms and is often complicated by Horner’s syndrome. In the review of literature, there are 23 reported cases of ganglioneuroma in the head/neck with a median age of 17 years. Eight of these occurred in the para/retropharyngeal spaces. Of these, five presented as an asymptomatic neck mass, two presented with compressive symptoms, and one was discovered incidentally. It is important to consider ganglioneuroma in the workup of pediatric neck masses, even in young children. Asymptomatic masses should be monitored for symptomatic transformation, and excision should be considered.
Langerhans cell histiocytosis mimicking acute otitis media in childhood—a case presentation
Authors: Ocal F. Ceyda Akin , Satar Bulent , Bozlar Uğur , Safali Mukerrem 
Published: August 2022

Abstract
Background
Langerhans cell histiocytosis (LCH) is an abnormal polyclonal proliferation of Langerhans cells that affect different parts of the body. Temporal bone involvement is quite common among the involved sites. The etiology is unknown. Diagnosis is based on symptoms, imaging, and histopathology. Especially LCH in temporal bone is confused with acute or subacute otitis media. There are many treatment options in LCH.

Case presentation
Here, a 2-year-old pediatric patient with pain in the right ear was diagnosed as having LCH as a result of the examinations. MRG revealed multiple lesions in the temporal bone, sphenoid bone, and clivus. She was treated with steroids and vinblastine.

Conclusion
Possible tumoral formations should be kept in mind when children complain of otalgia and otitis media-like clinical picture for a long time.
Reduced T-shaped soil domain for nonlinear dynamic soil-bridge interaction analysis
Authors: d’Avila Maria Paola Santisi , Lenti Luca , Gobbi Stefania , Fares Reine 
Published: August 2022

AbstractThe one-directional three-component wave propagation in a T-shaped soil domain (1DT-3C) is a numerical modeling technique, in a finite element scheme, to investigate dynamic soil-structure interaction (SSI) coupled with seismic site effects, under the assumption of vertical propagation of three-component seismic motion along a horizontal multilayered soil. A three-dimensional elasto-plastic model is adopted for soils, characterized using their shear modulus reduction curve.In this research, the 1DT-3C wave propagation modeling technique is proposed as an efficient tool for bridge design to take into account directly the spatial variability of seismic loading. This approach, in the preliminary phase of bridge study and design, allows the reduction of the soil domain and the easier definition of boundary conditions, using geotechnical parameters obtained with only one borehole investigation for each pier. This leads to a gain in modeling and computational time.
Two hours method for RNA and DNA co-extraction from blood of coronary artery disease patients: Fast, simple and economical technique
Authors: Dandare Abdullahi , Rafiq Muhammad , Liaquat Afrose , Jawad Khan Muhammad 
Published: August 2022

Objectives: Extraction of DNA and RNA is the first step in genomics and transcriptomics studies. Phenol-chloroform method for DNA extraction has been the widely used method. However, this method is relatively expensive and time-consuming. The objective of the present study was to validate a cost and time-effective protocol that will reduce the burden of molecular biology-based research and make a difference in laboratories with limited resources.
Methods: A comparative study was conducted at Syed Qamer Alam Research Laboratory, Shifa College of Medicine; from February, 2021 to August, 2021. TRIzolTM method was used to extract RNA from blood samples of coronary artery disease patients and remnant was used to extract DNA. The quantity, purity and integrity of the extracted DNA by both methods (TRIzol and phenol-chloroform) was examined. PCR product amplification was performed with thrombomodulin (THBD) gene to validate the characteristic of the extracted DNA and its efficiency for downstream experiments.
Results: The DNA yield in the TRIzolTM method was three-fold higher than phenol chloroform method. Both methods showed intact genomic DNA on the agarose gel, and extracted DNA was efficient for PCR amplification.
Conclusion: The TRIzolTM method for RNA and DNA co-extraction is fast, simple and economical technique. So, it can be adopted for routine molecular biology analyses in limited resources setup.
doi: https://doi.org/10.12669/pjms.38.7.5509
How to cite this:Dandare A, Rafiq M, Liaquat A, Khan MJ. Two hours method for RNA and DNA co-extraction from blood of coronary artery disease patients: Fast, simple and economical technique. Pak J Med Sci. 2022;38(7):---------. doi: https://doi.org/10.12669/pjms.38.7.5509
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Clinico-pathological features and related risk factors of Type-2 diabetes mellitus complicated with nonalcoholic fatty liver
Authors: Chen Lisha , Jiang Li 
Published: August 2022

Objectives: To analyze the clinicopathological features and risk factors of Type-2 diabetes mellitus (T2DM) patients with non-alcoholic fatty liver disease (NAFLD).
Methods: The data of 145 patients with T2DM who received treatment in our hospital from May 2020 to May 2021 were collected. The patients were diagnosed with NAFLD by abdominal liver Doppler ultrasound; The general data and laboratory examination indexes of T2DM patients with and without NAFLD were compared; To analyze the risk factors of NAFLD in T2DM patients.
Results: According to the results of the ultrasound examination, 71(48.97%) patients were simple T2DM, and 74(51.03%) patients were T2DM with NAFLD. Compared with simple T2DM, T2DM patients with NAFLD had higher BMI, hypertension, fasting plasma glucose(FPG), insulin resistance, triglycerides (TG), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and uric acid(UA) (P<0.05). Further logistic regression analysis showed a higher BMI (OR=1.841, P=0.013), FPG (OR=1.576, P=0.014), insulin resistance (OR=4.195, P<0.001) and elevated TG (OR=4.676, P=0.042) are risk factors for T2DM with NAFLD.
Conclusion: High BMI, BPG, insulin resistance index and TG are independent risk factors for nonalcoholic fatty liver in T2DM patients. During intervention, attention should be paid to the monitoring of these indicators to effectively prevent the aggravation of the disease.
doi: https://doi.org/10.12669/pjms.38.7.6289
How to cite this:Chen L, Jiang L. Clinico-pathological features and related risk factors of Type-2 diabetes mellitus complicated with nonalcoholic fatty liver. Pak J Med Sci. 2022;38(7):---------. doi: https://doi.org/10.12669/pjms.38.7.6289
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
What are the effects of taking 300 pills of sodium valproate? - case report
Authors: Pożarowska Kinga , Brzuszkiewicz Kinga , Rudziński Gracjan , Tchórz Michał 
Published: August 2022

INTRODUCTION: Sodium valproate is one of the most important antiepileptic drugs. It can be effective as a preventive treatment for migraine, it has also found use in the maintenance treatment of bipolar disorder and acute mania,it is sometimes used in the treatment of chronic neuropathic pain and fibromyalgia, in the treatment of schizophrenia borderline personality disorder and acquired brain injury, this drug is used off-label. Its overdose can be fatal.
MATERIALS AND METHOD: Patient information was collected from hospital records available in the clinical toxicology department. In addition, we conducted a literature review on sodium valproate treatment, its toxicity, side effects and pharmacokinetics using PubMed.
CASE REPORT: A 57-year-old patient with a history of depressive disorders was admitted to the Clinical Department of Toxicology and Cardiology in Lublin for intentional intoxication with the drug Absenor (sodium valproate). The patient had taken 3 packages of Absenor 500 mg (300 tablets in total) for suicidal purposes. The determined concentration of valproic acid was 841 µg/ml, and the patient's condition was very severe. Despite the treatment administered-multiple attempts at gastric lavage, administration of activated charcoal, performance of hemodialysis procedures, administration of infusion of catecholamines, the patient died on the fifth day of hospitalization.
CONCLUSION: An overdose of sodium valproate can be fatal. Keep this in mind when ordering this drug for patients with a positive history of suicide attempts.
Posture Analysis With REBA And RULA Methods At PT. PAGILARAN Batang Central Java
Authors: Zaini Muhammad Arul 
Published: August 2022

Abstract One of the levels of worker productivity is influenced by work posture. Work posture is an important aspect that needs to be considered in the industrial world, especially in the production process activities. Movement errors that are carried out repeatedly over a long period of time will cause fatigue of musculoskeletal disorders (loading errors on muscles and skeleton) and this can reduce the performance of workers in doing their work. So it is necessary to analyze the work posture of workers or employees using the REBA (Rapid Entire Body Assessment) and RULA (Rapid Upper Limb Assessment) methods which are work posture research methods to investigate disorders of the limbs. Based on the results of data processing using the REBA method, it can be concluded that the work posture in the wet sorting sector has a score of 9. This work posture really needs to be improved and will cause a high impact / risk if it continues. In the results of data processing using the RULA method, the work posture of the milling station workers has a final score of 7. This means that the work posture needs to be improved. The work posture at the two stations to be improved immediately in order to minimize the fatality that occurs in the worker's body posture
Measuring Performance Using Balanced Scorecard
Authors: Setiowati Noni Oktiana , Syukri Siti Husna Ainu 
Published: August 2022

Abstract

Small and medium enterprises (SME) have become the backbone of Indonesia domestic economy and accountable for Indonesia Gross Domestic Product (GDP). Yogyakarta is known for many metal casting SMEs including SP Aluminium which produce household appliances and crafts. The competition between SMEs that continues to increase will require company performance measurements that are not only based on financial aspects, but also emphasize the balance of other aspects such as the Balanced Scorecard method. Currently, many SMEs such as SP Aluminium have never carried out performance measurements outside financial aspects, while non-financial aspects are also important for business development. The objective of this study is to measure SP Aluminium performance using Balanced Scorecard. The results showed that for the Financial Perspective, SP Aluminium had exceeded ROI and Profit Margin targets, but the Revenue Growth Indicator only reached the company target in 2013. For the Customer Perspective, Customer Profitability had exceeded the target and keeps increasing, but Customer Growth sharply decreased in 2015 and didn’t reach the company target. There are 3 indicators who meet the company target on Internal Business Process Perspective: Product Innovation, Operation Process, and After-sales Process. Meanwhile another indicator, Defective Product Ratio did not meet the company’s target. For Learning & Growth Perspective, Employee Productivity had exceeded the company target since 2013. Meanwhile for Employee Satisfaction indicator, 76,40% of the employees were satisfied working in SP Aluminium. But Work Accident indicator needs more attention because the measurements result showed that the accidents occurred in the company always increased every year and far exceeded the set target.

Keyword: SME, Balanced Scorecard, Performance Measurement