bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-Talk Between n6-Methyladenosine and Their Related RNAs Defined a Signature and Confirmed m6A Regulators for Diagnosis of Endometriosis
Authors: Wang Xiaotong , Zhao Xibo , Wu Han , Wang Jing , Cheng Yan , Guo Qiuyan , Liang Tian , Zhang Guangmei 
Published: November 2022

Abstract
Background
An RNA modification known as n6-methyladenosine (m6A) interacts with a range of coding and non-coding RNAs. The majority of research focused on identifying m6A regulators that are differentially expressed in endometriosis but ignored their mechanisms which derived from the alterations of modifications among RNAs, affecting the disease progression primarily. Here, we aimed to investigate the potential roles of m6A regulators in the diagnostic potency, immune microenvironment, and clinicopathological features in endometriosis through interacting genes.
Results
A thorough investigation of the m6A modification patterns in the GEO database was carried out, based on mRNAs and lncRNAs related to these m6A regulators. Two molecular subtypes were identified with different infiltration levels of immune microenvironment cells and clinical features using unsupervised clustering analysis. We identified two m6A regulators, named METTL3 and YTHDF2, as diagnostic targets of endometriosis following the usage of overlapping genes to construct a diagnostic m6A signature of endometriosis. Finally, we found that m6A alterations might be one of the important reasons for the progression of endometriosis, especially with significant down-expressions of METTL3 and YTHDF2.
Conclusion
M6A modification patterns play significant effects on the diversity and complexity of the progression and immune microenvironment and might be key diagnostic markers for endometriosis.
Synthesis and characterization of new Ba-Sn-Al-CO 3 hydrotalcite and its application in various catalytic synthesis
Authors: Sharma Varsha , Mishra Praveena , Srivast Priyanka , Prajapati Pooja , Srivast Sakshi , Sharma Arun , Shankhwar Virendra , Shrivastava Sanjay K. , Agarwal Dau D. 
Published: November 2022

Abstract
We report an easy and novel synthesis of Ba-Sn-Al-CO3 hydrotalcite (HTs) which can be used as heterogeneous basic catalyst via co-precipitation method. The HTs formation have been determined by various techniques. Basic catalyst activity has been evaluated for various reactions such as multicomponent reaction and catalytic depolymerisation process. Multicomponent synthesis of 4H-pyran derivatives (Knoevenagel condensation) was carried out and yield obtained was 95%. Moreover, production of 80% biofuel using waste plastic using catalytic depolymerisation method was also carried out. This solid base catalyst has several benefits like short reaction time, environment friendly, higher yield, easy to separate, and economical cost.
Accumulation capacity of nickel and zinc in yerba mate cultivated in soils with contrasting parent materials
Authors: Ulbrich Nayara Caroline Majewski , Motta Antônio Carlos Vargas , Magri Ederlan , Prior Stephen A. , Albuquerque Carla Gomes , Gavelaki Fabiana , Barbosa Julierme Zimmer , Wendling Ivar , Poggere Giovana Clarice 
Published: November 2022

Abstract
Yerba mate (Ilex paraguariensis St. Hill.) has shown a relatively high capacity for metal absorption and accumulation under field conditions. To further evaluate the accumulation capacity of Ni and Zn, yerba mate clonal seedlings were grown in containers under five rates of Ni or Zn (0, 0.5, 2, 10, and 40 mg kg-1) with three soils originating from different parent material (basalt, rhyodacite, and sandstone). After 10 months, plants were harvested, divided into component parts (leaves, branches, and roots), and evaluated for 12 elements. Use of Zn and Ni enhanced seedling growth under rhyodacite- and sandstone-derived soils at the first application rate. Application of Zn and Ni resulted in linear increases based on Mehlich I extractions; recovery of Ni was smaller than Zn. Root Ni concentration increased from approximately 20 to 1000 mg kg-1 in rhyodacite-derived soil and from 20 to 400 mg kg-1 in basalt- and sandstone-derived soils; respective increases in leaf tissue were ~3 to 15 mg kg-1 and 3 to 10 mg kg-1. For Zn, maximum obtained values were close to 2000, 1000, and 800 mg kg-1 for roots, leaves, and branches for rhyodacite-derived soils, respectively. Corresponding values for basalt- and sandstone-derived soils were 500, 400, and 300 mg kg-1, respectively. Although yerba mate is not a hyperaccumulator, this species has a relatively high capacity to accumulate Ni and Zn in young tissue with the highest accumulation occurring in roots.
Subtractive Genome Analysis for Identification and Characterization of Novel Drug Targets in the Streptococcus pneumoniae by Using In-silico Approach
Authors: Sheoran Sumit , Arora Swati , R Samson Raj , Singh Prachi , kala Shashi , Velingkar Aayushi , Mohamed Ahmed Khaireh 
Published: November 2022

Abstract
As per WHO, the pneumococcus causes one million fatalities each year because of their underdeveloped immune systems, children are the most vulnerable to pneumococcal infections. The rise of S. pneumoniae resistance to antibiotics is causing widespread alarm all across the globe. Since the last couple of years, a recently developed technique is being used to overcome resistant pathogens. One of these is the computational subtractive genomics technique, in which the bacterial pathogen full proteins are effectively decreased to a limited amount of probable therapeutic targets. The procedures employed in this strategy are to locate human non-homologs targets, proteins that are vital to the illness producing agent, and participation of the identified proteins in pathogen metabolic pathways that are required for bacterial survival. In this work, we applied computational subtractive genomics on the proteins of the S. pneumonia strain D39 and came up with three cytoplasmic proteins that can serve as a promising candidate for novel drug to control the pathogenicity caused by S. pneumoniae.
Water Cycle Health Assessment and Obstacle Factor Analysis Based on Combined Weight and Hook Trapezoid Fuzzy TOPSIS Model
Authors: Zhao Mengdie , Li Jinhang , Zhang Yuansheng , Han Yuping , Wei Jinhai 
Published: November 2022

Abstract
The regional water cycle reflects both natural and social processes. The health of the regional water cycle is of great significance to the sustainable development of human beings. Focusing on the nine provinces and regions in the Yellow River Basin, this study utilized the DPSIRM model, including 21 basic indicators. In this paper, according to the principle of minimum information entropy, the three-scale AHP and EFAST algorithms were combined and weighted, and water cycle health status in the nine provinces and regions was evaluated based on the hook trapezoidal fuzzy TOPSIS model. Moreover, the traditional TOPSIS model was compared with the FCE method so as to evaluate the objectivity of the results. The obstacle degree model was introduced to obtain the main obstacle factors affecting the improvement of water circulation health in the nine provinces and regions. The results show that the water circulation health status in the nine provinces and regions is tending towards health, coordination, and balance. Water consumption in the ecological environment, water consumption per CNY 10,000 of GDP and forest coverage rate are the key factors that influence the improvement of water circulation health in the nine provinces and regions. The research results herein provide a scientific reference for the nine provinces and regions to achieve a healthy urban water cycle and regional sustainable development.
Invasion history, distribution and ecology of the aquatic alien Elodea canadensis (Hydrocharitaceae) in Turkey
Authors: İkinci Nursel 
Published: November 2022

AbstractSubmerged macrophyteElodea canadensisMichx. is a non-native species to Turkey where it was first recorded in 1982. In this study, we aim to provide the current distribution ofE. canadensisin Turkey with notes on its invasion history and ecology. We performed field studies to measure the physical and chemical parameters of the invaded lakes. Our study is based on new field works, herbarium specimen examination and literature survey. As a result of our findings,E. canadensishas invaded 15 wetlands in eight water basins of Turkey. Eleven of the invaded wetlands, including the largest freshwater lake of Turkey have protection forms ranging from national parks, nature parks to nationally/locally protected areas. Type of the wetlands are also diverse, like drainage canals, ancient pools, karstic, crater, tectonic and alluvial set lakes with trophic status from oligotrophic to eutrophic. We found water temperature between 15.5–22.3°C, pH between 7.1–8.6, dissolved oxygen as 3.7–8,8 mg l-1, electrical conductivity as 230–610 µS cm-1, salinity between 0.1–0.29 ppt, and ammonium as 0.25–0.74 mg l-1. Elevational range of the colonized wetlands ranges from sea level to c. 2100 m a. s. l.Elodea canadensisforms single species stands in many sites, but we could totally record 22 accompanying macrophyte taxa in species rich habitats. Here we present the most comprehensive distribution and ecology data forE. canadensisin Turkey which, could be used for further research and management to understand its future spread and effect on native vegetation.
Effects of Genetic Relatedness of Kin Pairs on Univariate ACE Model Performance
Authors: Lyu Xuanyu , Garrison S. Mason 
Published: November 2022

Abstract
Statistical power is important for genetically informed research, especially when using publicly available datasets. Such datasets can make research conclusions more generalizable, but accurate records of zygosity are not always obtainable. Some researchers tend to fit models with other kin pairs rather than MZ and DZ twins, who have a less than .5 genetic relatedness difference (ΔR). However, no research has systematically investigated the impact of using such two groups of kin pairs on ACE model performance. In our study, we did mathematical derivations and simulations to illustrate how genetic relatedness of same-sex twins (RSS) and sample sizes influence ACE model performance. Specifically, we analyzed those factors’ impact on statistical power of heritability (h2) estimation, the overall power, and the frequency of negative estimates based on univariate ACE models. Our algebraic and simulation results suggest that heritability power, overall power, and reduction of negative estimates are positively associated with larger RSS and larger sample sizes. We also found addressing sex limitations would cause slightly worse model performance under most circumstances. Simulation results were discussed from both statistical and empirical perspectives, and suggestions are proposed for studies using kin pairs with ΔR < .5.
An Efficient Video Frames Retrieval System Using SURF Based Bag of Visual Words
Authors: Hussain Altaf 
Published: November 2022

Abstract

Most of the work done in the CBIR system is done using images databases of different classes. There is a Lack of an automatic video frame retrieval system based on the query image. Low-level features i.e. shape and colors of most of the objects are almost the same e.g. sun and orange both are round and red in color. Features used in most of the CBIR Paper work are non-invariant features which may affect the overall accuracy of the CBIR system. The use of simple and weak classifier or matching technique may also affect the accuracy of the CBIR system on high scale. Un-availability of datasets for content-based video frames retrieval system is also a Paper issue. In this Paper these issues will be entertained.
States and Micronations in Cyberspace under Public International Law: A Legal Analysis of the Case of the Republic of Errant Menda Lerenda
Authors: Zhuk Alesia 
Published: November 2022

Abstract
The purpose of this article is to analyse whether the Republic of Errant Menda Lerenda (¨REML¨) can be considered a micronation or a State under public international law, based on existing doctrine and the actual situation of other states similar to the REML, whose performance in the legal framework of public international law has led to a rethinking of basic postulates. Both cases analyse whether a nation and a State can exist solely in cyberspace.
For the purposes of this article, the analysis is based on the following assumptions: 1.- More than one REML can exist, and for the purposes of this conclusion, possible problems arising from the use of the same flag or name are not considered. 2.- It is assumed that the REML that is the subject of this study was created first and is the subject of the document in Appendix 1-3, which is assumed to be correct in date, content and other considerations. 3.- As a working assumption, it is assumed that the REML has a territory (consisting of a sovereign and its space) and that the entire population of the REML is a sovereign.
A high urinary urobilinogen / serum total bilirubin ratio reported in abdominal pain patients can indicate acute hepatic porphyria
Authors: Song Chengyuan , Liu Yuan 
Published: November 2022

Abstract
Background: Due to its variable symptoms and nonspecific laboratory test results during routine examinations, acute hepatic porphyria (AHP) has always been a diagnostic dilemma for physicians. Misdiagnoses, missed diagnoses, and inappropriate treatments are very common. Correct diagnosis mainly depends on the detection of a high urinary porphobilinogen (PBG) level, which is not a routine test performed in the clinic and highly relies on the physician’s awareness of AHP. Therefore, identifying a more convenient indicator for use during routine examinations is required to improve the diagnosis of AHP.
Results: In the present study, we retrospectively analyzed laboratory examinations in 12 AHPpatients and 100 patients with abdominal pain of other causes as the control groups between 2015 and 2022. Compared with the control groups, AHP patients showed a significantly higher urinary urobilinogen level during the urinalysis (P < 0.05). However, we showed that the higher urobilinogen level was caused by a false-positive result due to a higher level of urine PBG in the AHP patients. Moreover, a remarkable increase in the urinary urobilinogen/serum total bilirubin ratio was observed in AHP patients when compared to the control groups. The area under the ROC curve of this ratio for AHP was 1.000 (95% confidence interval, 1.000–1.000, P < 0.01). A cutoff value of 3.22 for the urinary urobilinogen/serum total bilirubin ratio yielded a sensitivity of 100% and a specificity of 100% to distinguish AHP patients from the controls.
Conclusion: A reported high urinary urobilinogen level that was adjusted by the serum total bilirubin level (urinary urobilinogen/serum total bilirubin ratio) could be used as a sensitive and specific screening marker for AHP in patients with abdominal pain.
Compositional trends in Ba-, Ti-, and Cl-rich micas from metasomatized mantle rocks of the Gföhl Unit, Bohemian Massif, Austria
Authors: Zelinková Tereza , Racek Martin , Abart Rainer 
Published: November 2022

Abstract
Ba-, Ti-, and Cl-rich micas associated with other Ba- and/or Cl-rich minerals in the rock matrix or in garnet and clinopyroxene hosted multiphase solid inclusions (MSI) are observed in mantle-derived garnet pyroxenites. The micas show extremely high variability in chemical composition ranging between Ba-rich phlogopite, chloroferrokinoshitalite, and oxykinoshitalite. Elemental covariation trends in mineral chemical data reveal the principal substitution mechanisms responsible for the observed chemical variability. The substitution Ba2+Al3+ ↔ K1+Si4+ associated with either OH1– ↔ Cl1– or Ti4+2O2– ↔ Mg2+2OH1 links phlogopite to chloroferrokinoshitalite and oxykinoshitalite, respectively, whereas the substitution Ti4+2O2– ↔ Fe2+2Cl1– links chloroferrokinoshitalite to oxykinoshitalite. The preferred incorporation of Cl in Fe-rich mica and of Ti+O in Mg-rich mica indicates that XFe (Fetot/Fetot+Mg) exerts an important control on mica composition. The positive correlation of XFe with Cl led to the formation of possibly the most Cl-rich mica so far described classified as chloroferrokinoshitalite (XFe0.88, Ba0.95K0.03Fe2.68Mg0.37Al1.91Si2.01Cl1.98) with 10.98 wt% Cl. Substantial substitution of OH– by Cl– and O2– in mica, and the presence of Cl-apatite, a rare Cl-rich phosphate goryainovite, and carbonates together with Cl-rich micas indicate high-Cl and -CO2 activity and low-H2O activity in metasomatizing fluids or melts that may be classified as Ba-Cl-rich silicocarbonatitic. The coexistence of two micas with distinct compositions close to chloroferrokinoshitalite (XFe0.57–0.77, K~0.1Ba0.6–0.8Mg0.7–1.3Fe1.7–2.3Ti0.0–0.1 Si2.2–2.3Al1.5–1.7Cl1.2–1.8) and oxykinoshitalite (XFe0.19–0.20, K~0.3Ba~0.5Mg2.0–2.1Fe~0.5Ti0.2–0.4Si2.4–2.6Al~1.8Cl~0.3) suggests that a miscibility gap exists between these two compositions. The exotic mineral assemblage was formed by interaction with metasomatizing fluids or melts whose origin cannot be defined with certainty. They may be derived from crustal or mantle lithologies or from the host garnet pyroxenites. The textural position of the MSI in garnet and their characteristic mineral assemblages indicate that they have been introduced into the garnet crystals under post-peak conditions, possibly during decompression. With this research we document substitution mechanisms in Ba-, Ti-, and Cl-rich micas and shed light on the behavior and composition of fluids or melts at the upper mantle/lower crust interface.
Recent Advancements in the Discovery of MDM2/MDM2-p53 Interaction
Inhibitors for the Treatment of Cancer
Authors: Bhatia Neha , Khator Rakesh , Kulkarni Swanand , Singh Yogesh , Kumar Pradeep , Thareja Suresh 
Published: November 2022

Abstract:
Discovery of MDM2 and MDM2-p53 interaction inhibitors changed the direction
of anticancer research as it is involved in about 50% of cancer cases globally. Not only
the inhibition of MDM2 but also its interaction with p53 proved to be an effective strategy
in anticancer drug design and development. Various molecules of natural as well as
synthetic origin have been reported to possess excellent MDM2 inhibitory potential. The
present review discusses the pathophysiology of the MDM2-p53 interaction loop and
MDM2/MDM2-p53 interaction inhibitors from literature covering recent patents. Focus
has also been put on characteristic features of the active site of the target and its desired
interactions with the currently FDA-approved inhibitor. The designing approach of previously
reported MDM2/MDM2-p53 interaction inhibitors, their SAR studies, in silico
studies, and the biological efficacy of various inhibitors from natural as well as synthetic
origins are also elaborated. An attempt is made to cover recently patented MDM2/MDM2-
p53 interaction inhibitors.
Anti-Platelet Peptides Targeting αIIbβ3 Outside-In Signaling Pathway
Authors: Xu Xin , Wang Jialing 
Published: November 2022

Abstract:
Platelets and their progenitors express high levels of integrin αIIbβ3, which plays a key role
in platelet functions, hemostasis, and arterial thrombosis. Because of their quick and high efficacy, the
three anti-αIIbβ3 drugs, abciximab, eptifibatide, and tirofiban, are regarded as potent anti-thrombotics
and clinically approved by US Food and Drug Administration. However, because they interfere with
the inside-out signaling of αIIbβ3, which is required for stable platelet adhesion and aggregation, the
application of abciximab, eptifibatide, and tirofiban is restricted to patients undergoing percutaneous
coronary intervention. On the other hand, the outside-in signaling of αIIbβ3 in platelets appears to be
responsible for thrombus stabilization, and selective interference with the propagation of outside-in
signals might signify a new therapeutic strategy to preferentially inhibit platelet-rich arterial thrombosis
with less bleeding issues caused by way of compromised major hemostasis. The purpose of this
review is to describe the bidirectional signal transduction of integrin αIIbβ3 in platelets with a focus on
outside-in signaling, more efficient and safer anti-αIIbβ3 peptides, and the potential drug targets for
future anti-platelet research.
Targeting the Cancer Stem Cells in Endocrine Cancers with Phytochemicals
Authors: Gor Ravi , Ramachandran Ilangovan , Ramalingam Satish 
Published: November 2022

Abstract:
Endocrine cancer is an uncontrolled growth of cells in the hormone-producing glands. Endocrine cancers include the adrenal, thyroid, parathyroid, pancreas, pituitary, and ovary malignancy. Recently, there has been an increase in the incidence of the most common endocrine cancer types, namely pancreatic and thyroid cancers. Cancer stem cells (CSCs) of endocrine tumors have received more attention due to their role in cancer progression, therapeutic resistance, and cancer relapse. Therefore, finding the natural phytochemicals that target the CSCs will help improve cancer patients' prognosis and life expectancy. Phytochemicals have also been shown to have anti-CSCs and are very effective in treating various cancer types. Curcumin is a common polyphenol found in turmeric, which has been shown to promote cellular drug accumulation and increase the effectiveness of chemotherapy. Moreover, various other phytochemicals such as resveratrol, genistein, and apigenin are effective against different endocrine cancers by regulating the CSCs. Therefore, phytochemicals have emerged as chemotherapeutics that may have significance in preventing and treating endocrine cancers.
cGAS-STING Pathway as the Target of Immunotherapy for Lung Cancer
Authors: Ge Hong , Dan Qinfu , Yang Yang 
Published: November 2022

Abstract:
Immunotherapy has completely changed the treatment pattern of lung cancer and significantly prolonged the overall survival of patients, especially for advanced patients. However, a large number of lung cancer patients are unable to benefit from immunotherapy, which forces us to find new therapeutic targets to overcome drug resistance to immunotherapy. Cyclical GMP-AMP synthetase (cGAS) recognizes cytoplasmic DNA and promotes the formation of cyclical GMP-AMP (cGAMP), activates stimulator of interferon genes (STING), then induces the expression of varieties pro-inflammatory cytokines and chemokines, and then promotes the cross-presentation of dendritic cells (DCs) and initiates tumor-specific CD8+T cell response, showing great potential to overcome resistance and enhance antitumor immunity. In this review，we describe recent advances in the biological function，activation mode， and current applications of cGAS-STING pathway in lung cancer therapy. We also describe the mechanisms of the inactivation of cGAS-STING pathway in lung cancer cells， hoping to promote the progress of immunotherapy of lung cancer by targeting cGAS-STING pathway.