bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of a One-Day Driving Workshop for Combat Veterans During COVID-19
Authors: Stetten Nichole , Wandenkolk Isabelle , Jeghers Mary , Poojary Prerna , Winter Sandra , Classen Sherrilene 
Published: March 2022

Abstract
Background: Driving fatalities are a leading cause of death among combat Veterans. To improve Veterans' fitness-to-drive abilities, evidence-based interventions must be implemented. Objectives: Assess the feasibility of a one-day driving intervention for combat Veterans. Methods: The study objectives were examined using feasibility guidelines that examine recruiting capability; data collection procedures and outcome measures; acceptability and suitability of the intervention; available resources and participant responses. Results: COVID-19 and the study’s inability to convert to an online format (due to engagement with the driving simulator) hindered recruitment and study participation. Additional challenges for participants include fear of consequences from study participation, self-reflection of driving habits, workshop time burden, restrictive eligibility criteria and competing with another Veteran study. Conclusions : Despite meeting criteria for feasibility success, COVID-19 posed difficulties the study was unable to overcome. As recruitment efforts evolve to an online format, targeted social media marketing may be considered.
Comparison of Potassium-Competitive Acid Blockers and Proton Pump Inhibitors in Preventing Delayed Bleeding after Endoscopic Submucosal Dissection of Early Gastric Cancer: An Update Systematic Review and Meta-Analysis
Authors: Li Peng , Han Muzhou , Shi Haiyun , Cheng Rui , Liu Simao , Zhu Siying 
Published: March 2022

Abstract
Background: Proton pump inhibitors (PPIs) and potassium-competitive acid blocker (PCAB) are two different drugs that may be used after upper gastrointestinal endoscopic submucosal dissection (ESD). However, whether PCAB can reduce postoperative complications more than PPIs is a matter of controversy.Methods: We searched studies that reported the effectiveness of PCAB and PPIs in preventing delayed bleeding after gastric ESD by using PubMed, EMBASE, the Cochrane Library, Web of Science, etc. The Cochrane Risk of Bias Tool and Newcastle Ottawa Quality Assessment Scale were applied to evaluate the quality of the researches. All statistical analyses were carried out using Stata 15.1,including drawing the forest map, subgroup analysis, sensitivity analysis and detection of publication bias.Results: Seventeen studies with 51294 patients were included. There was a statistically difference in the overall delayed bleeding rate between the Vonoprazan group and the PPIs group. The overall mean relative risk (RR) for delayed bleeding following the administration of Vonoprazan was 0.72 (P<0.05) with a 95% confidence interval (CI) (0.67-0.77). However, there was no statistically difference in the incidence of blood transfusion events between the two groups[RR=0.76,95% CI (0.41-1.40)]. There was a statistical difference in the shrinkage ratio between the Vonoprazan group and the PPIs group. The weighted mean difference was 2.68(P<0.05) with a 95% CI (0.44-4.91). The sensitivity analysis showed all results were robust.Conclusions: Compared with PPIs, Vonoprazan showed a better efficacy in reducing the incidence of delayed bleeding and promoting the contraction of artificial ulcers. It might be an appropriate choice that postoperative management of gastric ESD in patients with stomach neoplasms.
Host-dependent resistance of Group A Streptococcus to sulfamethoxazole mediated by a horizontally-acquired ECF transporter S component
Authors: Rodrigo M Kalindu , Saiganesh Aarti , Hayes Andrew , Anstey Jack , Iwasaki Jua , Pickering Janessa , Hillas Jessica , Winslow Scott , Woodman Tabitha , Lacey Jake , Linden Mark van der , Giffard Philip , Tong Steven , Stubbs Keith , Carapetis Jonathan , Bowen Asha , Davies Mark , Barnett Timothy 
Published: March 2022

Abstract
Described antimicrobial resistance mechanisms enable bacteria to avoid the direct effects of antibiotics and can be monitored by in vitro susceptibility testing and genetic methods. We have identified a new mechanism of sulfamethoxazole resistance that requires a host metabolite for activity. Using a combination of in vitro evolution and metabolic rescue experiments, we identified an energy-coupling factor (ECF) transporter S component gene (thfT) that enables Group A Streptococcus to acquire extracellular tetrahydrofolate and related compounds. ThfT likely modifies the substrate specificity of an ECF transporter to acquire the end products of folate biosynthesis. As ThfT-mediated resistance is undetectable by routine surveillance methods, our study highlights the need to understand antibiotic susceptibility during infection to reduce inappropriate antibiotic use and treatment failures.
Spatial distribution of soil organic matter and total nitrogen under relay strip intercropping system
Authors: Te Xiao , Hassan Muhammad Jawad , Cui Kuoshu , Xiao Jiahui , Aslam Muhammad Naveed , Saeed Amjad , Yang Wenyu , Ali Safdar 
Published: March 2022

Abstract
Assessing the spatial distribution of organic matter and total nitrogen in soil is essential for management and optimum utilization of fertilizers in order to obtain better crop yield with minimum fertilizers cost. Subsequently, this field experiment has studied the impact of different planting patterns arrangements of maize and soybean strip relay intercropping on spatial distribution of soil total nitrogen and organic matter contents. The planting was arranged in a manner that soil sampling could be done from continuous maize/soybean relay strip intercropping (MS1), maize/soybean relay strip intercropping in rotations (MS2), Traditional maize/soybean intercropping (MS3), sole maize (M), sole soybean (S), and fallow land (FL) from 2018 to 2020. The results showed significant variations for soil organic matter and total nitrogen under different planting patterns of maize and soybean in intercropping. The highest soil organic matter (29.19 g/kg) and total nitrogen (10.19 g/kg) were MS2. In contrast the minimum organic matter (1.69 g/kg) and total nitrogen (0.64 g/kg) were FL. Soil organic matter and total nitrogen in MS2 increased by 186.45% and 164.06%, respectively, compared with FL. Furthermore, under MS2, the spatial distribution of soil organic matter was higher in both maize and soybean crop rows as compared with other cropping patterns, whereas the soil total nitrogen was higher under soybean rows as compared with maize in all other treatment. However, the correlation analysis of the treatments showed variations for organic matter. It can be concluded that different planting patterns can have other effects on soil organic matter and total nitrogen distribution under intercropping. Moreover, it is recommended from this study that MS2 is a better planting pattern for strip intercropping, that can increase spatial distribution of soil organic matter and total nitrogen, consequently it can improving the soil fertility and C:N ratio.
Characterization of Danube Swabian population samples on a high-resolution genome-wide basis
Authors: Bánfai Zsolt , Kövesdi Erzsébet , Sümegi Katalin , Büki Gergely , Szabó András , Magyari Lili , Ádám Valerián , Pálos Ferenc , Miseta Attila , Kásler Miklós , Melegh Béla 
Published: March 2022

Abstract
Background
German-derived ethnicities are one of the largest ethnic groups in Hungary, dating back to the formation of the Kingdom of Hungary, which took place at the beginning of the 11th century. Germans came to Hungary in many waves. The most significant immigration wave took place following the collapse of the Ottoman Empire in East-Central Europe which closed the 150-year long Ottoman occupation. To date, there are no comprehensive genome-wide studies investigating the genetic makeup of the Danube Swabians. Here we analyzed 47 Danube Swabian samples collected from elderly Danube Swabian individuals living in the Dunaszekcső-Bár area, Danube side villages in Southwest Hungary. Based on self-declaration they did not admix with other ethnic groups for 3–6 succeeding generations. Using Illumina Infinium 720K Beadchip genotype data, we applied allele frequency-based and haplotype-based genome-wide marker data analyses to investigate the ancestry and genetic composition of the collected Danube Swabian samples.
Results
Haplotype-based analyses like identity by descent and homozygosity by descent analyses show that the investigated Danube Swabians remained isolated from other ethnic groups which was supported by the D-statistics results. According to our results, the investigated Danube Swabian individuals do not possess detectable recent admixture, and our results suggest that their main source of ancestry can be traced back to the region of Germany.
Conclusions
This is the first analysis of Danube Swabian population samples based on genome-wide autosomal data. Our results establish the basis for conducting further comprehensive research on Danube Swabians and on other German ethnicities of the Carpathian basin, which can help reconstruct their origin, and identify their major archaic genomic patterns.
The Role of ATP-binding Cassette Transporter Genes Expression in Treatment Failure Cutaneous Leishmaniasis
Authors: Boozhmehrani Mohammad Javad , Eslami Gilda , Khamesipour Ali , Jafari Abbas Ali , Vakili Mahmood , Hosseini Saeedeh Sadat , Askari Vahideh 
Published: March 2022

Abstract
Leishmaniasis is one of the common diseases transmitted by sand flies in tropical and subtropical regions of the world. Currently, antimonial derivatives are the first line of treatment. Some of the members of the ATP-binding cassette (ABC) family of Leishmania are shown to be associated with no response to treatment. In this study, we evaluated ABCI4 , ABCG2, ABCC7, ABCB4, and ABCC3 genes expression in Leishmania isolated from patients with non-healing cutaneous leishmaniasis and treatment response isolates. We selected 17 clinical isolates (8 treatment failure and 9 treatment response) obtained from patients of Health Center Laboratory of Varzaneh, Isfahan, Iran, from September 2020 to March 2021 with cutaneous leishmaniasis. The diagnosis was performed using microscopic observation. The samples were directly collected from the lesions. The expression profiling of genes was assessed using SYBR Green real-time PCR that was analyzed with delta-delta Ct. All treatment failure clinical isolates were L. major . Gene expression analysis in treatment failure isolates showed that the ABC transported genes had a different pattern in each isolate. Treatment failure has been reported for cutaneous leishmaniasis worldwide. Knowledge of the molecular mechanisms of treatment failure could solve this problem. ABC transporter genes are considered controversial over the mechanisms of treatment failure outcomes. In this study, we showed that ABC transporter genes could be considered one of the important mechanisms.
Characteristics of neutralization process of acid mine drainage with steel slag
Authors: Yang Lei , Tang Yuegang , Yang Mingyuan , Cao Duanning , Lu Cunfang , He Yuanyuan 
Published: March 2022

Abstract
Steel slag has been proven to be an effective environment remediation media for acid neutralization, and a potential aid to mitigate acid mine drainage (AMD) in passive treatment process. In application, the acid neutralization capacity (ANC) of the steel slag is often decreased after a period of use because of the precipitate formation. However, the characteristic of the formation process are unclear yet. In this work, we tested the ANC of the commonly used Basic Oxygen Furnace (BOF) steel slag by titration of simulated AMD (H2SO4, 0.1M) and real AMD from abandoned coal mine drainage in the southwestern of China. The result indicated that there was a linear relationship between pH value and titrated AMD amount, for both simulated AMD and real AMD. When the pH decreased to 7, the titrated AMD amount and ANC were about 40ml and 8mmol H+/g slag for simulated AMD. At the beginning of the titration process, dissolution and hydration reactions of the easily dissolved calcium-containing constitute played a dominant role, and then were the precipitation formation reactions. The turning point for the two reactions was occurred when 20 % of the total titrated amount was titrated. Meanwhile, the BOF slag surface became smooth, and the dissolution reactions were hindered when the slag surface was clogged by the new formed crystallized gypsum. Further titration experiments results by real AMD also confirmed the ANC variation of BOF samples during the neutralization process.
Burnout among Psychotherapists: A Cross-cultural Value Survey among 12 European Countries during the Coronavirus Disease Pandemic
Authors: Hoy Angelika Van , Rzeszutek Marcin , Pięta Małgorzata , Mestre Jose M. , Mora Álvaro Rodríguez , Midgley Nick , Omylinska-Thurston Joanna , Dopierala Anna , Falkenström Fredrik , Ferlin Jennie , Gergov Vera , Lazić Milica , Ulberg Randi , Røssberg Jan Ivar , Hancheva Camellia , Stoyanova Stanislava , Schmidt Stefanie , Podina Ioana , Ferreira Nuno , Kagialis Anthony , Löffler-Stastka Henriette , Gruszczyńska Ewa 
Published: March 2022

Abstract
Objective
The aim of this study was to examine cross-cultural differences, as operationalized by Schwartz's refined theory of basic values, in burnout levels among psychotherapists from 12 European countries during the coronavirus disease (COVID-19) pandemic. We focused on the multilevel approach to investigate if individual- and country-aggregated level values could explain differences in burnout intensity after controlling for sociodemographic and work-related characteristics and COVID-19-related distress among participants.
Methods
In this study, 2915 psychotherapists from 12 countries (Austria, Bulgaria, Cyprus, Finland, Great Britain, Serbia, Spain, Norway, Poland, Romania, Sweden, and Switzerland) participated in this study. The participants completed the Maslach Burnout Inventory-Human Service Survey, the revised version of the Portrait Values Questionnaire, and a survey questionnaire on sociodemographic and work-related factors.
Results
Multilevel analysis revealed that burnout at the individual level was negatively related to self-transcendence and openness-to-change values but positively related to self-enhancement and conservation values. However, no significant effects on any values were observed at the country level. Moreover, male sex, younger age, being single, and reporting higher COVID-19-related distress were identified as significant burnout correlates.
Conclusions
Burnout among psychotherapists may be a transcultural phenomenon, where individual differences among psychotherapists are likely to be more important than differences between the countries of their practice. This finding enriches the discussion on training in psychotherapy in an international context and draws attention to the neglected issue of mental health among psychotherapists in the context of their professional functioning.
A comparison of magnetic resonance imaging and cone beam computerized tomography in the evaluation of temporomandibular joint changes in rheumatoid arthritis patients
Authors: Jalal Ranj Adil , Ahmed Khadija Muhamad , Saeed Shahla Muhamad 
Published: March 2022

Abstract
Objectives: This study aimed to determine the features of temporomandibular joint involvement in rheumatoid arthritis patients and to examine the association of radiographic changes with RA duration by comparing the diagnostic efficacy of cone-beam computerized tomography to magnetic resonance imaging in identifying changes of TMJs.Methods: This case-control study was performed on 40 RA patients with 10 healthy adults (control cases). Clinical examination with CBCT and MRI as well as laboratory tests were done for participants. Independent and paired t-tests and correlation coefficient test were used for data analysis by SPSS program Results: The frequency of TMJ involvement using CBCT and MRI techniques were 82.5% and 87.5% in RA patients and were 50% and 30% in control cases. The most frequently observed clinical symptom was facial pain (25%), and the slightest symptom was clicking (2.5%) during mouth opening. The commonest change in CBCT of RA patients was condylar head erosion (67.5%), and the less common change was articular eminence erosion (7.5%). The commonest changes in MRI of RA patients were an osseous change of condylar head (80%), and the minor change was effusion (10%), while in controls were an osseous change of condylar head (30%) and condylar head flattening (10%). There was a positive correlation between ESR, RF, and Anti-CCP and osseous TMJ changes, while CRP shows a negative correlation. Conclusions: Osseous changes occur in TMJs of RA patients with no/mild symptoms, MRI can be used as efficient imaging modality for detecting changes in TMJ, and elevated ESR, RF and Anti-CCP may indicate the presence of osseous changes in RA patients.
Clinical efficacy of osimertinib in EGFR-mutant non-small cell lung cancer with distant metastasis
Authors: Gen Soei , Tanaka Ichidai , Morise Masahiro , Koyama Junji , Kodama Yuta , Matsui Akira , Miyazawa Ayako , Hase Tetsunari , Hibino Yoshitaka , Yokoyama Toshihiko , Kimura Tomoki , Yoshida Norio , Sato Mitsuo , Hashimoto Naozumi 
Published: March 2022

Abstract
Background: Osimertinib—the third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)—has been widely used as a first-line treatment for patients with metastatic EGFR-mutant non-small cell lung cancer (NSCLC). Osimertinib demonstrated central nervous system activity in patients with brain metastasis; however, its efficacy against other distant metastatic organs, including bone and liver, remains unclear. Therefore, we retrospectively analyzed the clinical efficacy of osimertinib in these patients in comparison to other EGFR-TKIs.Methods: Clinical data of patients with advanced NSCLC receiving gefitinib/erlotinib (n=183), afatinib (n=55), or osimertinib (n=150) at five medical institutions were retrospectively assessed for progression-free survival (PFS), overall survival (OS), and best overall response rate (ORR).Results: In univariate and multivariate analyses, most distant metastases, including the brain and bone, were unrelated to the therapeutic efficacy of osimertinib, although liver metastasis and L858R mutation were independently associated with shorter PFS. PFS and OS in patients with liver metastases were significantly shorter than those in patients without liver metastases (PFS: 7.4 vs. 19.7 months, OS: 12.1 months vs. not reached, respectively). Osimertinib provided significantly longer PFS in patients with brain or bone metastasis and exon 19 deletion than the other EGFR-TKIs. The PFS of patients with liver metastases was not significantly different among the three EGFR-TKI groups. Furthermore, the ORR of osimertinib in patients with liver metastases was significantly attenuated, and the effectiveness was similar to 1st- or 2nd -generation EGFR-TKIs.Conclusion: Osimertinib provided better clinical benefits than 1st- and 2nd-generation EGFR-TKIs for patients with EGFR-mutant NSCLC, particularly those with brain or bone metastases and exon 19 deletion; however, its efficacy against liver metastasis was remarkably attenuated. New therapeutic developments for patients with EGFR-mutant NSCLC with liver metastases are needed.
The tool-use cortical network contributes to semantic neural representations
Authors: Thibault Simon , Koun Eric , Salemme Romeo , Boulenger Véronique , Roy Alice Catherine , Brozzoli Claudio 
Published: March 2022

Abstract

Tool use and language are two highly refined human abilities which may have co-evolved, thus resulting in neural commonalities. We recently provided evidence for shared neural resources between tool use and syntax. However, the debate is still open on whether semantics and phonology also recruit neurofunctional supplies common to tool use. Here we tested the hypothesis that activity within the tool-use network contributes to semantic and phonological neural representations. To this aim, we identified the tool-use network with fMRI while participants used pliers. The same participants underwent, a semantic and a phonological task to evidence the underlying networks. Through a series of representational similarity analyses we tested whether activity in tool-use clusters contributed to neural representations of semantic and phonological stimuli. The results revealed that semantic activity patterns within the left inferior frontal gyrus and left occipitotemporal cortex, activated by tool use, displayed significant similarity between nouns belonging to the same semantic category. Activity in tool-use related areas therefore contributes to semantics. By contrast, no significant relationship was observed for the activity patterns elicited by phonological stimuli. These findings suggest that semantics is grounded within the tool-use network, reinforcing the hypothesis of a functional link between semantics and tool use.
Assessing energy transition vulnerability over nations and time
Authors: Shen Yifan , Shi Xunpeng , Zhao Zhibo 
Published: March 2022

Abstract
While achieving the Paris climate goals and sustainable development goals (SDGs) are two major global challenges of our time, energy transition that plays an essential role in achieving climate targets may create socio-economic hardship. A quantitative assessment of the vulnerability of energy transitions is a prerequisite for national and international policymakers to advance a just energy transition that looks after coordination between energy transitions and socio-economic development. This study proposes to measure energy transition vulnerability from the dimensions of exposure, sensitivity, and adaptive capacity. The results of energy transition vulnerability index (ETVI) scores for 135 nations reveal a huge inequality across nations; moreover, the COVID-19 pandemic has interrupted the decade-long continuous improvement of energy transition vulnerability. Developed countries usually have low energy transition vulnerability than developing countries and the gaps even have been widened. The existing global transition vulnerability could be mitigated by 12.3 p.p and 5.2 p.p if each nation could follow the path of global or climate party group frontiers in achieving the SDGs, despite the scale and drivers of mitigation vary across countries. The study also suggests that heterogeneous transition policies that consider both emissions and vulnerability are required. Our framework and findings could advise policymakers to formulate policies and cooperation strategies to reduce vulnerability, protect vulnerable countries, and make fair energy transition policies nationally and internationally.