bluuebunny/crossref_metadata_2025_split huggingface dataset:
Covid-19 and comedications in atrial fibrillation – a case-control study in Stockholm
Authors: Bell Max , Ekbom Anders , Linder Marie 
Published: August 2022

Abstract
ObjectivesTo test the main hypothesis that anticoagulation reduces risk of hospitalization, intensive care unit (ICU) admission and death in COVID-19.DesignNested case-control study among patients with atrial fibrillation (AF) in Stockholm. Cases were matched to five controls with same sex, born within +/- 1 years, and without COVID-19.SettingSource population was individuals in Stockholm with AF 1997-2020. Swedish regional and national registers are used. National registers cover hospitals and outpatient clinics, local registers cover primary care. Records were linked through the personal identity number assigned to each Swedish resident.ParticipantsCases were individuals with diagnosis of, ICU admission for, or death with COVID-19. The source population consisted of 179,381 individuals from which 7,548 cases were identified together with 37,145 controls. The number of cases (controls) for hospitalization, ICU admission and death were 5,916 (29,035), 160 (750) and 1,472 (7,360). The proportion of women was 40% for hospitalization and death, but 20% and 30% for admission to ICU in wave one and two, respectively. Main outcome measuresPrimary outcome was mortality, secondary outcome was hospitalization, tertiary outcome was ICU admission, all with COVID-19.ResultsOdds ratios (95% confidence interval) for antithrombotics were 0.79 (0.66 to 0.95) for the first wave and 0.80 (0.64 to 1.01) for the second wave.ConclusionsUse of anticoagulation among patients with COVID-19 and arrythmias is associated with lower risk of hospitalization and death. If further COVID-variants emerge, or other infections with prothrombotic properties, this emphasize need for physicians to ensure compliance among vulnerable patients.
Electro-osmosis and coupled stress effect on peristaltic power-law fluid flow with gold nanoparticles through a non-Darcy porous medium
Authors: Eldabe N. T. , Abou-zeid M. Y. , Seliem A. S. Abo , Elenna A. A. , Hegazy N. 
Published: August 2022

Abstract
In this work, we studied the electro-osmotic peristaltic motion of nano-coupled stress fluid with heat transfer through a non-uniform inclined channel. The flow in this discussion obeys the power-law model through a non-Darcy porous medium. The system is stressed by an external magnetic field. Moreover, the effects of thermal radiation, heat generation, Ohmic dissipation and chemical reaction are taken in consideration. The governing equations that describe the velocity, temperature and nanoparticles concentration are simplified under the assumption of long wavelength and low-Reynolds number. The resulting system of partial differential equations is solved numerically. The effects of the physical parameters of the problem with these solutions are discussed and illustrated through a set of figures. It is found that the axial velocity profiles decrease with the raising of electro-osmotic parameter.
Early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection: a national population-based matched cohort study
Authors: Stock* Sarah , Calvert Clara , Carruthers Jade , Denny Cheryl , Donaghy Jack , Hillman Sam , Hopcoft Lisa , Hopkins Leanne , Goulding Anna , Lindsay Laura , McLaughlin Terry , Moore Emily , Pan Jiafeng , Taylor John , Almaghrabi Fatima , Auyeung Bonnie , Bhaskaran Krishnan , Gibbons Cheryl , Katikireddi Srinivasa , McCowan Colin , Murray Josie , O’Leary Maureen , Ritchie Lewis , Shah Syed , Simpson Colin , Robertson Chris , Sheikh Aziz , Wood Rachael 
Published: August 2022

Abstract
There are limited data regarding the safety of COVID-19 vaccines in early pregnancy. This may contribute to vaccine hesitancy in people who are pregnant, or who are planning pregnancy. We conducted a population-level matched cohort study assessing associations between COVID-19 vaccination and miscarriage (pregnancy loss prior to 20 weeks gestation) and ectopic pregnancy. We used electronic health records of all female residents in Scotland who were vaccinated between 6 weeks preconception and 19 weeks 6 days gestation (for miscarriage; n = 18,780) or 2 weeks 6 days gestation (for ectopic; n = 10,570). Primary analyses used unvaccinated women from the pre-pandemic period as controls (historical controls) matched (3:1) on maternal age, gestational age at vaccination, and season of conception; with adjustment for maternal deprivation level, rural/urban status and clinical vulnerability. Supplementary analyses used unvaccinated women from the pandemic period as controls (contemporary controls). Analyses of outcomes following SARS-CoV-2 infection were undertaken with infection rather than vaccination as the exposure. Following COVID-19 vaccination, the rate of miscarriage was 9.1% (n = 1,716) and ectopic pregnancy 1.2% (n = 126). Primary analyses found no association between vaccination and miscarriage (adjusted Odds Ratio [aOR] = 1.02, 95% Confidence Interval [CI] = 0.96–1.09) or ectopic pregnancy (aOR = 1.13, 95% CI = 0.92–1.38). Primary analyses also found no association between SARS-CoV-2 infection and miscarriage or ectopic pregnancy. Results of supplementary analyses were similar to primary analyses. Given that SARS-CoV-2 infection in later pregnancy carries substantial risks to women and babies, our findings support current recommendations that vaccination remains the safest way for pregnant women to protect themselves and their babies from COVID-19.
Data mining on identifying diagnosis and prognosis biomarkers in head and neck squamous carcinoma
Authors: Ju Guoyuan , Yao Zhangyu , Zhao Yanbin , Zhao Xiaotong , Liu Fangzhou 
Published: August 2022

Abstract
Background: Head and neck squamous carcinoma (HNSC) is cancer with a poor prognosis that induces high cancer-related death worldwide. The biomarker screening on diagnosis and prognosis is of great importance. This research is aimed to explore the specific diagnostic and prognostic biomarkers for HNSC through bioinformatics analysis.Results: The mutation and dysregulation data were acquired from UCSC Xena and TCGA databases. The top ten genes with mutation frequency in HNSC were TP53 (66%), TTN (35%), FAT1 (21%), CDKN2A (20%), MUC16 (17%), CSMD3 (16%), PIK3CA (16%), NOTCH1 (16%), SYNE1 (15%), LRP1B (14%). A total of 1,060 DEGs were identified, with 396 up-regulated and 665 downregulated in HNSC patients. Patients with lower expression of ACTN2 (P=0.039, HR=1.3), MYH1 (P=0.005, HR=1.5), MYH2 (P=0.035, HR=1.3), MYH7 (P=0.053, HR=1.3), and NEB (P=0.0043, HR=1.5) exhibit longer overall survival time in HNSC patients. The main DEGs were further analyzed by pan-cancer expression and immune cell infiltration analyses. We can observe that MYH1, MYH2, and MYH7 were dysregulated in the cancers. Compared with HNSC, their expression levels are lower in the other types of cancers. All the five DEGs have a significant positive correlation with CD4+ T cells and macrophages.Conclusion: ACTN2, MYH1, MYH2, MYH7, and NEB genes were significantly associated with poor prognosis in HNSC. Moreover, MYH1, MYH2, and MYH7 were expected to be the specific diagnostic and prognostic molecular biomarkers of HNSC.
Health-related Quality of Life in Children under Treatment for Overweight, Obesity or Severe Obesity: a cross-sectional study in the Netherlands
Authors: Voorn Bibian van der , Camfferman Roxanna , Seidell Jacob C. , Halberstadt Jutka 
Published: August 2022

Abstract
Background
It is unknown whether weight class is associated with impairment of health-related quality of life (HRQOL) for children in the Netherlands. The aim of this study was to explore generic and weight-specific HRQOL in a clinical cohort of children with overweight, obesity or severe obesity aged 4–19 years in the Netherlands.
Methods
803 children from three clinical cohorts participated: mean age 11.5 (SD 2.9) years, 61.1% girls. The influence of weight class was explored in a subgroup of 425 children (25.2% with overweight, 32.5% obesity and 42.3% severe obesity), of whom the exact International Obesity Task Force (IOTF) BMI class was known. Generic HRQOL was measured by the PedsQL child report. Weight-specific HRQOL was measured by the IWQOL-Kids child or parent report. Average total, subscale and item scores were reported and the influence of the IOTF BMI class analyzed by multiple linear regression, corrected for age and sex.
Results
Children with severe obesity had lower generic and weight-specific HRQOL scores than those with obesity or overweight. IOTF BMI class was negatively associated with item scores from all subscales, especially physical, social and emotional problems. Children with overweight reported similar HRQOL total, subscale and item scores to children with obesity.
A Machine Learning Based Algorithm for Joint Improvement of Power Control, link adaptation, and Capacity in Beyond 5G Communication systems
Authors: Norolahi Jafar , Azmi Paeiz 
Published: August 2022

Abstract
In this study, we propose a novel machine learning based algorithm to improve the performance of beyond 5 generation (B5G) wireless communication system that is assisted by Orthogonal Frequency Division Multiplexing (OFDM) and Non-Orthogonal Multiple Access (NOMA) techniques. The non-linear soft margin support vector machine (SVM) problem is used to provide an automatic modulation classifier (AMC) and a signal power to noise and interference ratio (SINR) estimator. The estimation results of AMC and SINR are used to reassign the modulation type, codding rate, and transmit power throughout the frames of eNode B connections. The AMC success rate versus SINR, total power consuming, and sum capacity are evaluated for OFDM-NOMA assisted 5G system. In comparison to recently published methods, our results show that the success rate improves. The suggested method directly senses the physical channel because it computes the SINR and codding rate of received signal just after the signal is detected by successive interference cancellation (SIC). Hence, because of this direct sense, this algorithm can really decrease occupied symbols (overhead signaling) for channel quality information (CQI) in network communication signaling. The results also prove that the proposed algorithm reduces the total power consumption and increases the sum capacity during the eNode B connections. Simulation results compared to other algorithms show more successful AMC, efficient SINR estimator, easier practical implantation, less overhead signaling, less power consumption, and more capacity achievement.
Access to dermatologic care for adult and pediatric Medicaid patients: Acceptance rates, wait times and accountable care organization webpage accuracy
Authors: Kuceki Guilherme , Gardner Laura J. , Mortenson Brett C. , Secrest Aaron M. 
Published: August 2022

Abstract
Fewer U.S. dermatologists are accepting Medicaid plans over time. We sought to investigate whether there are discrepancies between Accountable Care Organization (ACO) webpage-reported dermatologist acceptance of Medicaid vs. actual acceptance of Medicaid via telephone calls to dermatology offices in Utah. Telephone calls were placed to each dermatology office in Utah posing as a patient requesting an appointment. We compared the information obtained over the phone with the ACO webpage and calculated wait time averages for appointments. The positive predictive values ranged from 83.1–95.5% depending on the ACO. *We also discovered that ACO webpages failed to list several dermatologists as accepting Medicaid who reported Medicaid acceptance on the telephone. We also compared waiting times for new patients with Medicaid to those with the leading medical insurance in Utah and found that the mean waiting time for adults with private insurance (3.0 days) was significantly shorter (p = 0.02) than adults with Medicaid (13.5 days) when the patient requested to be seen by a Physician Associate or Nurse Practitioner. For accurate information, Medicaid patients seeking dermatologic care should make telephone calls to local dermatology offices, rather than search for a Medicaid-listed provider on ACO webpages.
Dynamical equations and exact solvability of the Modified Emden equation under position-dependent mass settings
Authors: Mustafa Omar 
Published: August 2022

Abstract
We consider the modified Emden equation (MEE) for position-dependent mass (PDM) classical particles. We use the most general solution for the simple harmonic oscillator’s linear dynamical equation (i.e., the initial conditions shall be identified by the PDM-MEE problem at hand) and report the most general solution for the MEE. We map MEE-solution, using a nonlocal point transformation, into the effectively PDM-MEE. Two PDM-MEE-type classical particles are used as illustrative examples, and their exact solutions are reported. Under specific parametric considerations, the phase-space trajectories are reported for the MEE-type and for PDM-MEE-type classical particles.PACS numbers: 05.45.-a, 03.50.Kk, 03.65.-w
Source Mechanism and Tectonic Analysis of 06 May 2022 Mw 5.4 Khuzdar Earthquake along Western Boundary of the Indian Plate
Authors: Shaukat Ahmed Zeeshan , Tahir Mohammad , Iqbal Tahir , Iqbal Talat , Shah Muhammad Ali 
Published: August 2022

Abstract
On May 06, 2022 an earthquake of M5.4 occurred in NW of Khuzdar (Baluchistan), Pakistan. This event caused damages to infrastructure and collapsed several mud houses, according to local news agencies. On the same day, an earthquake of a similar size (M5.4) which is 230km away from the Khuzdar earthquake occurred in Dalbandin, Baluchistan. Both of these earthquakes were independent and have not appeared to be related with each other. The 2013 Awaran earthquake of magnitude 7.7 has been the largest event within this region, located 70 km away from a recent event. The recent seismicity within the Khuzdar area might be the post viscoelastic relaxation the of Awaran earthquake having the NE-SW nodal plane as the fault plane. To understand the faulting style and tectonic setting, moment tensor inversion was performed using local seismic data. The mechanism of this event was strike-slip (sinisteral faulting style) and associated with Ornach-Nal strike-slip fault. Based on 38 events focal mechanism solutions from the global Harvard Centroid Moment Tensor (CMT) of the Khuzdar region depict NW-SE orientation of SHmax direction. Reduced stress tensors obtained from formal stress inversion are then divided into two subsets (thrust and strike-slip) on basis of their stress homogeneity. The present-day stress state confirms, the oblique convergence of Indian and Arabian Plates beneath Eurasian which is subjected to a transpressional tectonic environment. A lower b-value (0.7) and accelerated earthquake sequence were observed in the Khuzdar region before this event. The spatial distribution of b-value depicts the lowest value in this region, before the occurrence of the Awaran earthquake. Although high differential stress was exhibited in this region but large has not occurred. These stresses were transferred to the western part, where the Awaran earthquake has been occurred.
Substance use among university students and affecting factors in Marrakech region, Morocco: a cross-sectional Study
Authors: BASLAM ABDELMOUNAIM , KABDY HAMID , MOUBTAKIR SOAD , ABOUFATIMA RACHIDA , BOUSSAA SAMIA , CHAIT ABDERRAHMAN 
Published: August 2022

Abstract
University is a period characterized by an absence of parental supervision and independence. Few research has been conducted in Morocco among this particular population, the aim of this study is to assess the prevalence to substance use among student, to develop knowledge of how and why substances are used and or abused.There were 1054 participants, divided into university student group (n=444) and non-student group (n=610) using a random sampling process for the university student group, and multistage stratified probability procedure for the other.The current study revealed that tobacco use was found the most prevalent substance used among university student representing 65,1%. While the prevalence of cannabis use was 29,1%, and psychotropic drugs was 2,5%.This study has demonstrated a high prevalence of substance use among young educated adults who should be role models for their community, fighting substance use rather than using it.
A Novel Platinum Resistance-related Immune Gene Signature for Overall Survival Prediction in Patients with Ovarian Cancer
Authors: Zhou Chenfei , Ma Junnan , Luo Wanjun , Hu Jiemei , Chen Jing , Liang Suiying , He Shanyang 
Published: August 2022

Abstract
Background
Ovarian cancer (OV) is a highly heterogeneous gynaecological tumor that makes the prognostic prediction challenging. Resistance to platinum-based chemotherapy is associated with a poor prognosis in OV. There seems to be an overlap between molecular mechanisms responsible for platinum resistance and immunogenicity in OV. However, the predictive role of platinum-resistance-related immune genes for OV prognosis needs to be further explored.
Methods
In our study, the mRNA expression data of OV patients with corresponding clinical information was collected from the TCGA and ICGC cohort. A multigene signature was constructed for OV patients in the TCGA cohort using the least absolute shrinkage and selection operator (LASSO) Cox regression model, and was validated in the ICGC cohort. Furthermore, we performed functional analysis to explore the immune status between the two risk groups.
Results
Our data showed that there were 41.1% of the platinum resistance-related genes differentially expressed between immune score low and high OV patients in the TCGA cohort. Univariate Cox regression analysis identified 30 differentially expressed genes (DEGs) associated with overall survival (OS) (P < 0.05). A 14-gene signature was established to classify OV patients into a low- and high-risk group. Patients in the low-risk group showed significantly higher OS than those in the high-risk group (P < 0.0001 in the both TCGA and ICGC cohort), which was associated with different immune status for the two risk groups.
Conclusion
A novel platinum resistance-related immune model can be used for prognostic prediction in OV. Targeting tumor immunity may be a therapeutic alternative for OV with platinum resistance.
Impact of hospital volume on mortality and cost in sepsis based on a Japanese nationwide medical claims database study—the Japan Sepsis Alliance study group
Authors: Oami Takehiko , Imaeda Taro , Nakada Taka‑aki , Aizimu Tuerxun , Takahashi Nozomi , Abe Toshikazu , Yamao Yasuo , Nakagawa Satoshi , Ogura Hiroshi , Shime Nobuaki , Umemura Yutaka , Matsushima Asako , Fushimi Kiyohide 
Published: August 2022

Abstract
Background:
The impact of hospital volume on the mortality rate and medical costs in sepsis has not been fully elucidated. We hypothesized that high-volume hospitals have low mortality rates and high medical costs in sepsis cases.
Methods:
This retrospective study used the administrative data from 2010 to 2017. The hospital volume categorization into quartiles was performed according to the annual number of sepsis cases. The primary outcome was in-hospital mortality. The secondary outcomes were medical costs and length of hospital stay. A mixed-effects logistic model with a two-level hierarchical structure was used to adjust for baseline imbalances. Fractional polynomials and restricted cubic splines were investigated to determine the significance of the association between the hospital volume and clinical outcomes. Subgroup and sensitivity analyses were performed for the primary outcome.
Results:
Among 1,781,014 sepsis patients from 1,622 hospitals, the crude in-hospital mortality rate was 22.1% and 17.0% in the lowest and highest quartile of sepsis volume, respectively (p < 0.0001). After adjustment for confounding factors, the in-hospital mortality in the highest quartile was significantly lower than that of the lowest quartile (odds ratio, 0.789; 95% confidence interval, 0.774–0.804; p < 0.0001). Investigations with fractional polynomials and restricted cubic splines revealed that the hospital volume was significantly associated with in-hospital mortality (p < 0.0001). The highest quartile had higher daily medical costs per person and shorter length of hospital stay than those of the lowest quartile. Subgroup analyses showed that the high-volume hospitals with patients subjected to intensive care unit admission, mechanical ventilation, vasopressor therapy, and renal replacement therapy had a significantly low in-hospital mortality (p < 0.0001). The sensitivity analysis, excluding patients who were transferred to other hospitals, demonstrated a result consistent with that of the primary test.
Conclusions:
This nationwide sepsis study using the medical claims database suggested that a higher hospital volume leads to lower in-hospital mortality and higher daily medical costs per person. Further research is needed to investigate the mechanism of the case volume–outcome relationship in sepsis cases.
Photosynthetic acclimation to chilling in the widespread chilling-tolerant cyanobacterium Nostoc commune
Authors: Chen Zhen , Yuan Zu-Wen , Luo Wei-Xin , Wu Xun , Shao Hai-Cheng , Xu Kui , Li Wei-Zhi , Xiong-Wen Xiong-Wen 
Published: August 2022

Abstract
Nostoc commune (N. commune) is a widespread chilling-tolerant cyanobacterium, whereas its photosynthetic acclimation to chilling remains largely unknown. Here, its photosynthetic responses to chilling were investigated. During 24 h exposure to chilling temperature (4 ºC), this cyanobacterium exhibited photosystem II (PSII) photoinhibition, as evident by the significant decrease in both the PSII maximum quantum yield Fv/Fm and the PSII core protein D1 abundance. However its photosystem I (PSI) maintained stable, both the maximum photo-oxidizable P700 and the PSI core protein PsaA/B abundance remained largely unchanged after chilling. Chilling activated the non-photochemical quenching to maintain energy balance of intersystem electron transport in N. commune, its quantum yield of regulated energy dissipation in PSII (Y(NPQ)) significantly rose by 41%, so that its PSII excitation pressure (1-qP) remained stable. Furthermore, the significant stimulation of cyclic electron flow (CEF) was observed upon the transfer to chilling and subsequent recovery in N. commune, and its photodamage in the presence of chloramphenicol was similar to that in the presence of methyl viologen, suggesting that CEF contributed to the PSII repair under chilling stress. The present data provide novel insight into photosynthetic acclimation to chilling, which benefit the survival of N. commune in cold habitats or during over-wintering periods and could be used as a reference for the design of robust photosynthetic cell factory.
High Gain 13-level Switched-Capacitor Based Inverter with Low Device Count
Authors: Jena Kasinath , Gupta Krishna Kumar , Dewangan Niraj Kumar , Kumar Dhananjay 
Published: August 2022

Abstract
This paper presents a novel single-phase multilevel inverter with boosting capabilities. The proposed inverter is powered by a single direct current supply, and it generates a thirteen-level voltage waveform utilizing fourteen switches, one diode, and three capacitors. The suggested inverter eliminates the need for a back-end H-bridge, and hence the voltage stress on all switches is less than the peak load voltage. The proposed topologys topological design, operation, and modulation strategy description are all analyzed in-depth, as is the power losses analysis. A detailed comparison with existing switched capacitor topologies (SCTs) proves the cost-effectiveness and compactness of the proposed topology. The MATLAB/Simulink environment and experimental setup were used to evaluate the effectiveness and feasibility of the proposed design