bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive Behavioral Therapy for Insomnia Among Active Duty Military Personnel Diagnosed With Obstructive Sleep Apnea
Authors: Hoyt Tim , Lee Marquisha R G , Stolee Jason D , Breitstein Joshua A , Kwon Herbert P , Mysliwiec Vincent 
Published: September 2022

ABSTRACT

Introduction
Insomnia and obstructive sleep apnea are common conditions among military service members, with high rates of comorbidity. Although cognitive behavioral therapy for insomnia (CBT-I) has been established as an effective treatment for insomnia, it is unclear whether or not CBT-I is effective among service members with comorbid insomnia and obstructive sleep apnea.

Materials and Methods
This retrospective, observational study examined insomnia outcomes among a group of service member patients (N = 73) with comorbid insomnia and obstructive sleep apnea. All patients received individual CBT-I in a specialty sleep clinic at a military treatment facility. Seven outcomes associated with insomnia were evaluated before and after treatment.

Results
On average, patients showed significant improvement in sleep onset latency, wake after sleep onset, sleep efficiency, number of awakenings, and symptoms reported on the Insomnia Severity Index. Twenty-six percent of patients showed clinically significant improvement in reported insomnia symptoms.

Conclusions
These results suggest that CBT-I may be effective in treating military service members with comorbid insomnia and obstructive sleep apnea. Despite the limitations of data collected in a clinical setting, consistent findings across five of the seven outcome measures provide good evidence that this treatment can be implemented in military settings.
Efficacy and tolerability of subcutaneously administered methotrexate including dose escalation in long-term treatment of rheumatoid arthritis in a Japanese population
Authors: Tanaka Yoshiya , Okuda Kosuke , Takeuchi Yohei , Katayama Kou , Haji Yoichiro , Yamanishi Yuji , Tribanek Michael , Guimbal-Schmolck Cecile , Takeuchi Tsutomu 
Published: September 2022

ABSTRACT

Objectives
The aim of this article is to evaluate the efficacy and safety of subcutaneously administered methotrexate (MTX) for Japanese patients with active rheumatoid arthritis.

Methods
MTX-naïve patients were randomized in a 1:1 ratio to receive a 12-week administration of either 7.5 mg MTX subcutaneously (MJK101, a prefilled syringe for subcutaneous injection) or 8 mg MTX orally in Part 1 of the trial. The primary end point was a 20% improvement in the American College of Rheumatology criteria (ACR20) at Week 12. In the second part, all enrolled patients received MJK101 weekly for 52 weeks with doses starting from 7.5 to 15 mg with 2.5 mg increments with the option of self-administration of MJK101.

Results
The efficacy of MJK101 was comparable to oral MTX following 12 weeks of treatment at the starting doses. A numerically higher ACR20 response rate and fewer adverse events in particular gastrointestinal adverse events were observed. During long-term subcutaneous treatment, MJK101 was well tolerated across all tested doses. Patients clinically improved upon dose escalation.

Conclusions
Subcutaneously applied MTX (MJK101) was efficient and well tolerated over a long-term treatment period in the Japanese population with doses up to 15 mg/week. Subcutaneous administration of MTX is a beneficial option for Japanese patients with rheumatoid arthritis.
Manufacturing Process of SER-109, a Purified Investigational Microbiome Therapeutic, Reduces Risk of Coronavirus Transmission From Donor Stool
Authors: McChalicher Christopher , Abdulaziz Ahmad , Zhou S Steve , Lombardo Mary-Jane , Hasson Brooke , Auniņš John G , McGovern Barbara H , Ege David S 
Published: September 2022

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may present risk to patients treated with donor-derived microbiome therapies when appropriate manufacturing controls and inactivation processes are lacking. We report that the manufacturing steps for SER-109, a purified investigational microbiome therapeutic developed to reduce risk of Clostridioides difficile recurrence, inactivate porcine epidemic diarrhea virus, a model coronavirus for SARS-CoV-2.
Early Experience Implementing Long-Acting Injectable Cabotegravir/Rilpivirine for Human Immunodeficiency Virus-1 Treatment at a Ryan White-Funded Clinic in the US South
Authors: Collins Lauren F , Corbin-Johnson Della , Asrat Meron , Morton Zoey P , Dance Kaylin , Condra Alton , Jenkins Kimberly , Todd-Turner Marie , Sumitani Jeri , Smith Bradley L , Armstrong Wendy S , Colasanti Jonathan A 
Published: September 2022

Abstract

Background
Long-acting injectable (LAI) antiretroviral therapy (ART) has the potential to improve medication adherence, reduce human immunodeficiency virus (HIV) stigma, and promote equity in care outcomes among people with HIV (PWH). We describe our early experience implementing LAI-cabotegravir/rilpivirine (CAB/RPV) for maintenance HIV-1 treatment.

Methods
We launched a pilot LAI-ART program at a large Ryan White-funded clinic in the Southeast, which accept provider-initiated referrals from April 14, 2021 to December 1, 2021. Our interdisciplinary program team (Clinician-Pharmacy-Nursing) verified clinical eligibility and pursued medication access for eligible patients. We describe (1) demographic and clinical variables of PWH referred and enrolled and (2) early outcomes among those accessing LAI-CAB/RPV.

Results
Among 58 referrals, characteristics were median age 39 (Q1–Q3, 30.25–50) years, 74% male, and 81% Black, and payor source distribution was 26% Private, 21% Medicare, 19% Medicaid, and 34% AIDS Drugs Assistance Program. Forty-five patients (78%) met clinical eligibility for LAI-CAB/RPV; ineligibility concerns included evidence of confirmed or possible RPV resistance (n = 8), HIV nonsuppression (n = 3), possible RPV hypersensitivity (n = 1), and pregnancy (n = 1). Among 45 eligible PWH, 39 (87%) enrolled and 15 (38%) initiated LAI-CAB/RPV after a median of 47 (Q1–Q3, 31–95) days since enrollment.

Conclusions
Implementing LAI-ART at a Southern US Ryan White-funded clinic has been challenged by the following: substantial human resource capital to attain drug, administer injections, and support enrolled patients; delayed therapy initiation due to insurance denials; patient ineligibility primarily due to possible RPV resistance; and inability to provide drug regardless of payor source. These barriers may perpetuate disparities in ART access and outcomes among PWH and should be urgently addressed so that LAI-ART can be offered equitably.
Botrytis cinereainfection accelerates ripening and cell wall disassembly to promote disease in tomato fruit
Authors: Silva Christian J , Adaskaveg Jaclyn A , Mesquida-Pesci Saskia D , Ortega-Salazar Isabel B , Pattathil Sivakumar , Zhang Lisha , Hahn Michael G , van Kan Jan A L , Cantu Dario , Powell Ann L T , Blanco-Ulate Barbara 
Published: September 2022

AbstractPostharvest fungal pathogens benefit from the increased host susceptibility that occurs during fruit ripening. In unripe fruit, pathogens often remain quiescent and unable to cause disease until ripening begins, emerging at this point into destructive necrotrophic lifestyles that quickly result in fruit decay. Here, we demonstrate that one such pathogen, Botrytis cinerea, actively induces ripening processes to facilitate infections and promote disease in tomato (Solanum lycopersicum). Assessments of ripening progression revealed that B. cinerea accelerated external coloration, ethylene production, and softening in unripe fruit, while mRNA sequencing of inoculated unripe fruit confirmed the corresponding upregulation of host genes involved in ripening processes, such as ethylene biosynthesis and cell wall degradation. Furthermore, an enzyme-linked immunosorbent assay (ELISA)-based glycomics technique used to assess fruit cell wall polysaccharides revealed remarkable similarities in the cell wall polysaccharide changes caused by both infections of unripe fruit and ripening of healthy fruit, particularly in the increased accessibility of pectic polysaccharides. Virulence and additional ripening assessment experiments with B. cinerea knockout mutants showed that induction of ripening depends on the ability to infect the host and break down pectin. The B. cinerea double knockout Δbc polygalacturonase1 Δbc polygalacturonase2 lacking two critical pectin degrading enzymes was incapable of emerging from quiescence even long after the fruit had ripened at its own pace, suggesting that the failure to accelerate ripening severely inhibits fungal survival on unripe fruit. These findings demonstrate that active induction of ripening in unripe tomato fruit is an important infection strategy for B. cinerea.
A common whole-genome paleotetraploidization in Cucurbitales
Authors: Wang Jiaqi , Yuan Min , Feng Yishan , Zhang Yan , Bao Shoutong , Hao Yanan , Ding Yue , Gao Xintong , Yu Zijian , Xu Qiang , Zhao Junxin , Zhu Qianwen , Wang Ping , Wu Chunyang , Wang Jianyu , Li Yuxian , Xu Chuanyuan , Wang Jinpeng 
Published: September 2022

Abstract
Cucurbitales are an important order of flowering plants known for encompassing edible plants of economic and medicinal value and numerous ornamental plants of horticultural value. By reanalyzing the genomes of two representative families (Cucurbitaceae and Begoniaceae) in Cucurbitales, we found that the previously identified Cucurbitaceae common paleotetraploidization that occurred shortly after the core-eudicot-common hexaploidization event is shared by Cucurbitales, including Begoniaceae. We built a multigenome alignment framework for Cucurbitales by identifying orthologs and paralogs and systematically redating key evolutionary events in Cucurbitales. Notably, characterizing the gene retention levels and genomic fractionation patterns between subgenomes generated from different polyploidizations in Cucurbitales suggested the autopolyploid nature of the Begoniaceae common tetraploidization and the allopolyploid nature of the Cucurbitales common tetraploidization and the Cucurbita-specific tetraploidization. Moreover, we constructed the ancestral Cucurbitales karyotype comprising 17 proto-chromosomes, confirming that the most recent common ancestor of Cucurbitaceae contained 15 proto-chromosomes and rejecting the previous hypothesis for an ancestral Cucurbitaceae karyotype with 12 proto-chromosomes. In addition, we found that the polyploidization and tandem duplication events promoted the expansion of gene families involved in the cucurbitacin biosynthesis pathway; however, gene loss and chromosomal rearrangements likely limited the expansion of these gene families.
Uncoupling differential water usage from drought resistance in a dwarf Arabidopsis mutant
Authors: Ginzburg Daniel N , Bossi Flavia , Rhee Seung Y 
Published: September 2022

Abstract
Understanding the molecular and physiological mechanisms of how plants respond to drought is paramount to breeding more drought-resistant crops. Certain mutations or allelic variations result in plants with altered water-use requirements. To correctly identify genetic differences which confer a drought phenotype, plants with different genotypes must be subjected to equal levels of drought stress. Many reports of advantageous mutations conferring drought resistance do not control for soil water content (SWC) variations across genotypes and may therefore need to be re-examined. Here, we reassessed the drought phenotype of the Arabidopsis (Arabidopsis thaliana) dwarf mutant, chiquita1-1 (chiq1-1, also called constitutively stressed 1 (cost1)), by growing mutant seedlings together with the wild-type to ensure uniform soil water availability across genotypes. Our results demonstrate that the dwarf phenotype conferred by loss of CHIQ1 function results in constitutively lower water usage per plant, but not increased drought resistance. Our study provides an easily reproducible, low-cost method to measure and control for SWC and to compare drought-resistant genotypes more accurately.
Ignorance-led port policing? The limits of information sharing–based policing in the North Sea Canal Area and Port of Amsterdam and in the Port of Moerdijk
Authors: Eski Yarin , Fiddelers Valérie 
Published: September 2022

Abstract
Whereas the Dutch government considers the Port of Rotterdam and Amsterdam Airport as crucial drug transport hubs for organized crime groups, there is scarce governance focus on the increasing shift of these groups to small, medium-sized, and (still) relatively anonymous Dutch ports, like the North Sea Canal Area (NSCA) and the Port of Moerdijk (PoM). They can be considered criminal diversion ports where port policing parties relies strongly on information sharing to establish intelligence-led port policing. What has remained un(der)studied are not only these criminal diversion ports, but also, and more specifically how and why (frontline) port policing staff (do not) share information and intelligence (position) with one another other. What are their motivations to withhold or share information? That is the key research question answered in this contribution by comparing two recent studies, one on the NSCA (Eski, Y., Boelens, M., Mesic, A., and Boutellier, H. (2021). Van Verhalen naar Verbalen: Een verkennende studie naar de aanpak van ondermijnende drugscriminaliteit in het Noordzeekanaalgebied en de haven van Amsterdam (NZKG). The Hague: Sdu.) and the other on the PoM (Fiddelers, V. [2021]. Intel aan het roer. Een studie naar informatiedeling binnen de politie ten behoeve van de aanpak ondermijnende criminaliteit in de haven van Moerdijk. Amsterdam: VU University.). By exploring comparatively the reasons the studies’ participants have, or think others have, for (withholding) information, this article considers to which extent Dutch small, medium-sized criminal diversion ports accommodate ignorance-led port policing (Reiner in Shepherd, J., Pease, K., Reiner, R., Squires, P., and Westmarland, L. (2010). ‘Debating Policing Research: A Research Council for Crime and Justice? Jonathan Shepherd and Ken Pease Call for Medical Research Standards to be Replicated in Policing Studies. Robert Reiner, Peter Squires, and Louise Westmarland respond.’ Criminal Justice Matters 80(1): 2–5.).
Analysing and communicating vulnerability to crime at micro-places: An empirical application of how to improve the visual representation of a spatial crime risk assessment in Iztapalapa, Mexico City
Authors: Dugato Marco 
Published: September 2022

Abstract
This paper proposes an alternative way to analyse and visualize vulnerability to crime at micro-places according to the different combinations of contextual elements that characterize them. The study focuses on violent crimes in the urban area of Iztapalapa, Mexico City. The identification of the risky places follows the Risk Terrain Modelling approach including both information on environmental elements and on the socio-demographic characteristics of the neighbourhoods. Cluster analysis is applied to classify and map these places according to the different environmental settings. The paper discusses how the suggested visual representations is a powerful communicative means to complement traditional risk maps that simply classify the areas according to their future crime likelihood. The paper argues that displaying the combination of crime correlates ensures more effective risk governance. The paper also indicates how effective communication and the selection of proper graphical visualization of analytical findings are pivotal for fostering collaboration between crime analysts, law enforcement agencies, and other stakeholders.
Anti-PM-Scl antibodies–positive patients encompass three different groups with distinct prognoses
Authors: Breillat Paul , Mariampillai Kuberaka , Legendre Paul , Martins Pauline , Dunogue Bertrand , Charuel Jean Luc , Miyara Makoto , Goulvestre Claire , Paule Romain , Vanquaethem Helene , Ackermann Felix , Benveniste Olivier , Nunes Hilario , Mouthon Luc , Allenbach Yves , Uzunhan Yurdagul 
Published: September 2022

AbstractObjectiveTo help identify homogeneous subgroups among patients with anti-PM-scleroderma-antibodies (PM-Scl-Abs) positive auto-immune diseases regardless of diagnostic classifications.Material and methodsThis multicentric (four hospitals) retrospective study collected all consecutive patients (from 2011 to 2021) with positive testing for anti-PM-Scl-Abs in a context of CTD. Subgroups of patients with similar clinico-biological phenotypes were defined using unsupervised multiple correspondence analysis and hierarchical clustering analysis of the features recorded in the first year of follow-up.ResultsOne hundred and forty-two patients with anti-PM-Scl-Abs were evaluated and 129 patients were included in the clustering analysis and divided into three clusters. Cluster 1 (n = 47) included patients with frequent skin thickening, digestive involvement and interstitial lung disease (ILD) with non-specific interstitial pneumonia (NSIP). They were more likely to develop progressive fibrosing ILD. Cluster 2 (n = 36) included patients who all featured NSIP with frequent organizing pneumonia–associated pattern and mechanic’s hands. This subgroup had increased risk of relapse and ILD was characterized by a good functional outcome. Cluster 3 (n = 46) was characterized by predominant or isolated musculoskeletal involvement and frequently matched UCTD criteria. Although very frequent among anti-PM-Scl-Abs positive patients, muscle involvement was less discriminating compared with skin thickening and ILD pattern to classify patients into subgroups.ConclusionAnti-PM-Scl-Abs associated auto-immune diseases are segregated into three subgroups with distinct clinical phenotype and outcomes. Skin thickening and NSIP are determinant predictors in segregation of theses populations.
An assessment of the US Small Business Innovation Research (SBIR) program: A study of project failure
Authors: Link Albert N , Swann Christopher A , van Hasselt Martijn 
Published: September 2022

AbstractIn 2000 and 2012, the US Congress charged the National Research Council (NRC) to study how the Small Business Innovation Research (SBIR) program had stimulated technological innovation and used small businesses to meet Federal research and development needs and to recommend program improvements. Using project data collected by the NRC, we suggest that an important assessment metric not previously considered by the NRC in its reports to Congress relates to the failure rate of funded Phase II research projects. We identify a number of covariates associated with project failure, and we recommend that program managers might decrease the likelihood of project failure if funded firms can be given relevant information about how to contact angel investors, venture capitalists, private investors, and the like, and how to present a proposal for additional research investment dollars. Our findings should have a direct benefit to other countries that have implemented SBIR-like programs.
‘A World Apart’: Change in Student Attitudes during the Interwar Period, 1918–1933
Authors: Harrington Neil 
Published: September 2022

Abstract
This article investigates student culture in interwar universities using the relatively neglected material of student magazines. Recent scholarship suggests that students became increasingly politically aware during the interwar period, accompanied by a significant shift in attitudes in the early 1930s. The present research argues that this change in attitudes was largely superficial, and that underlying ‘corporate’ values remained intact. This is evidenced by the involvement of ex-service students in strengthening corporate culture, and the close identification between these students and immediate ‘post-war’ students. Certainly, aspects of corporate culture were challenged later in the decade, when alongside the influence of pacifism there was a move from a ‘parochial’ style of magazine towards more ‘serious’ and ‘political’ articles. However, it is argued that this represented a temporary shift in focus, rather than a fundamental change in underlying values. Student attitudes continued to be embedded within an existing framework based on public school values, and reflecting a commitment to patriotism, duty, and social obligation.
Randomized Trial of Transversus Abdominis Plane Block With Liposomal Bupivacaine After Cesarean Delivery With or Without Intrathecal Morphine
Authors: Habib A.S. , Nedeljkovic S.S. , Horn J.L. , Smiley R.M. , Kett A.G. , Vallejo M.C. , Song J. , Scranton R. , Bao X. 
Published: September 2022

(J Clin Anesth. 2021;75:110527. doi: 10.1016/j.jclinane.2021.110527)
Intrathecal morphine (ITM) is regularly used for analgesia following cesarean delivery (CD), although there is no standardized dose. Employed as part of a multimodal analgesia system, recommended ITM dosing ranges from 50 to 150 µg. Dose-dependent opioid-related adverse events including vomiting, nausea, pruritus, and respiratory depression call for investigation into alternate methods that provide effective analgesia with fewer opioid-related adverse events. Previous studies of transverse abdominis plane (TAP) block with long-acting liposomal bupivacaine (LB) combined with ITM suggest enhanced analgesia compared to LB TAP or ITM alone. The comparison of efficacy and safety of LB TAP block with or without ITM (LB and LB + ITM) versus ITM alone has not been previously undertaken. The adequacy of analgesia including pain scores and postsurgical opioid consumption was studied for the 3 intervention groups (LB and LB + ITM, vs. ITM) with noninferiority tested before superiority.
Tranexamic Acid and Obstetric Hemorrhage: Give Empirically or Selectively?
Authors: Shander A. , Javidroozi M. , Sentilhes L. 
Published: September 2022

(Int J Obstet Anesth. 2021;48:103206)
Tranexamic acid (TXA) is an antifibrinolytic agent that promotes hemostasis by preventing blood clot deterioration. Common off-label uses of TXA include preventing and treating bleeding and blood loss in trauma, cardiac surgery, intracranial and subarachnoid hemorrhage, orthopedic and spinal surgery, and obstetric settings. Despite its common use, much is unclear about the effects, risks, mechanisms, and dosing of TXA. Since serious side effects like seizures and venous thrombo-embolic events have been observed, a closer look at the dosing and use of TXA is needed.
Early and Systematic Administration of Fibrinogen Concentrate in Postpartum Hemorrhage Following Vaginal Delivery: The FIDEL Randomized Controlled Trial
Authors: Ducloy-Bouthors A.S. , Mercier F.J. , Grouin J.M. , Bayoumeu F. , Corouge J. , Le Gouez A. , Rackelboom T. , Broisin F. , Vial F. , Luzi A. , Capronnier O. , Huissoud C. , Mignon A. ,   the FIDEL Working Group
Published: September 2022

(BJOG. 2021;128:1814–1823)
Postpartum hemorrhage (PPH) is the leading cause of maternal mortality worldwide. Plasma fibrinogen is the first coagulation factor to drop steeply during PPH. As fibrinogen concentration decreases, risk of severe PPH increases. When fibrinogen concentrations drop below 2 g/L, there is a 100% positive predictive value for severe PPH and fibrinogen replacement is recommended. However, systematic fibrinogen administration at an earlier time, specifically, before plasma level determination, may be more effective in avoiding the progression to severe PPH. This study aimed to determine whether early and systematic administration of 3 g fibrinogen concentrate could limit postpartum hemoglobin decrease by 4 g/dL and/or limit transfusion of packed red blood cells to fewer than 2 units.