bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integral equation for a solitary wave
Authors: Lavit Igor M. 
Published: February 2022

Abstract
The problem is formulated as a boundary-value problem for a strip in the complex potential plane and converted to a boundary-value problem for a half-plane by conformal mapping. The solution is obtained using a Cauchy type integral for the density of which a nonlinear integral equation is derived. Its solution is found with the Galerkin method and the Newton–Raphson technique. The calculated results are compared with the experimental data and the calculations by other researchers. The lower limit of the speed of a solitary wave is found.
Enhanced Stent Imaging System Guided Percutaneous Coronary Intervention İs Linked to Optimize Stent Placement
Authors: avci ilhan ilker , Zeren Gönül , Sungur Azmi , Akdeniz Evliya , Şimşek Barış , Yılmaz Mehmet Fatih , Can Fatma , Gürkan Ufuk , Karagöz Ali , Tanboğa İbrahim Halil , Karabay Can Yücel 
Published: February 2022

Abstract
Purpose: Stent under-expansion utmost importance for restenosis, also one of the strongest predictors of Stent Thrombosis is stent under-expansion. Thus, it remains uncertain whether Enhanced stent imaging (CLEARstent) guidance improved stent under-expansion.Our aim to assess the using Enhanced stent imaging (ESI) on stent under-expansion, after percutaneous coronary intervention (PCI, with using CLEARstent technology.Methods: This cross-sectional observational based on single center study. The subjects who applied to our cardiology clinic with stable angina or acute coronary syndrome, from March 2020 to September 2020 were recruited. A total of 164 patients who underwent post-PCI clear stent in the study group and age sex matched 77 control patients were included in the study. Post-procedural minimal lumen diameter (MLD) was calculated with quantitative coronary angiography module.Results: Approximately one third of the study population was in X-ray guided PCI group and two third of which was involved in ESI guided PCI group (32% and 68%, respectively, p=0.22). The patients in ESI guided PCI group, median age was 61 (54-69) years and 76.8% (n=126) of whom were male.The patients in ESI guided PCI group have higher minimal lumen area when compared to X-ray guided PCI group (2.88 (2.58-2.99) vs 2.55 (2.34-2.63), p<0.001).Conclusion: Our study addresses that use of ESI system with intend to optimize stent placement results in better procedural outcome expressed by MLD.
Upregulation of CYP1B1 by hypoxia is mediated by ERα activation in breast cancer cells
Authors: Min Jin Young , Lee Gi Ho , Khanal Tilak , Jin Sun Woo , Lee Sang-Yeop , Kim Hyung Gyun , Hyon Ju-Yong , Chung Young-Ho , Ha Sang Keun , Han Eun Hee , Jeong Hye Gwang 
Published: February 2022

Abstract
Background: Endocrine therapy for breast cancer often leads to drug resistance and tumor recurrence; tumor hypoxia is also associated with mortality and tumor relapse. Cytochrome P450 1B1 (CYP1B1) regulates estrogen metabolism in breast cells and is known to be overexpressed in breast cancer tissue. Although the individual association of hypoxia-induced hypoxia-inducible factor-1α (HIF-1α) and CYP1B1 with tumorigenesis is well known, the association between HIF-1α and CYP1B1 leading to tumorigenesis has not been investigated. Here, we investigated the correlation between hypoxia and CYP1B1 expression in breast cancer cells for tumorigenesis-related mechanisms. Methods: Hypoxia was induced in the human breast cancer cell lines MCF-7 (Er-positive) and MDA-MB-231 (triple-negative) and the normal breast epithelial cell line MCF10A, and then subjected to immunoblotting, transient transfection and luciferase assays, gene silencing using small interfering RNA, PCR analysis, and chromatin immunoprecipitation, co-immunoprecipitation, and mammalian two-hybrid assays. Furthermore, immunofluorescence analysis of tumor microarrays was performed and the pub2015 and The cancer genome atlas patient datasets were analyzed.Results: HIF-1α expression in response to hypoxia occurred in both normal and breast cancer cells, whereas CYP1B1 was induced only in estrogen receptor α (ERα)-positive breast cancer cells under hypoxia. HIF-1α activated ERα by direct binding as well as in a ligand-independent manner to promote CYP1B1 expression. Conclusions: Therefore, we established the mechanism by which hypoxia and ER-positivity orchestrate breast cancer relapse.
Tobacco smoking and depressive symptoms in Chinese middle-aged and older adults: Handling missing values in panel data with multiple imputation
Authors: Du Xiahua , Wu Rina , Kang Lili , Zhao Longlong , Li Changle 
Published: February 2022

Abstract
Background: The high co-occurrence of tobacco smoking and depression is a major public health concern during the novel coronavirus disease-2019 pandemic. However, no studies have dealt with missing values when assessing depression. Therefore, the present study aimed to examine the effect of tobacco smoking on depressive symptoms using a multiple imputation technique.Methods: This research was a longitudinal study using data from four waves of the China Health and Retirement Longitudinal Study conducted between 2011 and 2018, and the final sample consisted of 74,381 observations across all four waves of data collection. The present study employed a multiple imputation technique to deal with missing values, and a fixed effects logistic regression model was used for the analysis. Results: The results of fixed effects logistic regression showed that heavy smokers were 1.2 times more likely to suffer from depressive symptoms than those who never smoked. Compared to those who never smoked, for short-term and moderate-term quitters, the odds of suffering from depressive symptoms increased by 30% and 22%, respectively. The magnitudes of the odds ratios for of the variables short-term quitters, moderate-term quitters, and long-term quitters decreased in absolute terms with increasing time-gaps since quitting.Conclusions: The empirical findings suggested that among Chinese middle-aged and older adults, heavy smokers and short-term and moderate-term quitters were more likely to have depressive symptoms than those who never smoked. Moreover, former smokers reported that the probability of having depressive symptoms decreased with a longer duration since quitting. These results may have important implications that support the government in allocating more resources to smoking cessation programs to help middle-aged and older smokers.
Epidemiological characteristics of thoracolumbar fractures from 2014 to 2019 in Shanxi, China
Authors: Feng Hao-Yu , Li Qiang , Kang Yi , Gao Zhao , Wang Chao-Yu , Chen Chen , Zhang Hong-Yi , Zhang Ming , Zhao Jing , Zhou Heng-Xing , Feng Shi-Qing 
Published: February 2022

Abstract
Background: We aimed to clarify the epidemiological characteristics of thoracolumbar fractures (TLFs) at Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, China. Methods: A total of 1,096 patients with TLF between January 2014 and December 2019 were included in this retrospective study. Epidemiological characteristics (year, age, sex, marital status, occupation, injury level, etiology, fracture type, and American Spinal Injury Association ASIA impairment scale [AIS] grade) in medical records were extracted and analyzed.Results: The number of TLF cases increased between 2014 and 2019. More than half of the patients were between 40 and 75 years old. The most common fracture level was L1, with compression as the most common injury type. A total of 137 patients (12.5%) experienced spinal cord injury. The primary cause of fracture was a “low fall”, and farmers were most vulnerable. Epidemiological characteristics (age, year, etiology, fracture type, occupation, and spinal cord injury) were quite different between males and females. In patients with spinal cord injury, the most frequent age group was 46–60 years old. Again, the primary fracture level was L1, and the most common occupation was farmer. However, with this group, the primary fracture type was burst, and the main etiology was “high fall”.Conclusions: The number of patients with TLF increases with social development. The epidemiological profiles between sexes were quite different. Preventions and government regulations should be implemented to reduce the incidence of TLF, according to the epidemiological profiles of men and women.
Etiology and surgical treatment of pediatric trigger finger: Quantitative measurements of the cross-sectional configuration of the flexor tendon using ultrasonography
Authors: Kim Jihyeung , Li Qingyuan , Cao Linying , Baek Goo Hyun , Zhan Haihua 
Published: February 2022

Abstract
Background: This study quantitively evaluated the cross-sectional area of the flexor tendon and the area under the A1 pulley using ultrasonography in patients with unilateral pediatric trigger finger (PTF). The surgical outcome following release of the A1 pulley together with the proximal one-third of the A2 pulley was determined.Methods: We enrolled 32 trigger fingers of 29 patients diagnosed with unilateral PTF. The cross-sectional configuration of the flexor tendon was determined in 12 trigger fingers of 10 patients using ultrasonography. The ultrasonography measurements consisted of the anteroposterior (AP) diameter, radioulnar (RU) diameter, cross-sectional area of the flexor tendon at the level of the greatest AP diameter of the flexor tendon proximal to the A1 pulley, and the inner dimensions of the A1 pulley. The measurements were repeated on the contralateral normal same finger. The efficacy of the surgical release of the A1 pulley together with that of the proximal one-third of the A2 pulley was assessed in 11 trigger fingers of 11 patients who underwent surgical intervention for PTF.Results: The average RU measurement and cross-sectional area of the flexor tendon were larger than the inner dimensions of the A1 pulley in PTF patients. The average AP, RU, and cross-sectional area measurements in the area under the A1 pulley were significantly larger in the trigger finger than in the contralateral normal finger (P < 0.05). The average RU and cross-sectional area measurements of the flexor tendon proximal to the A1 pulley were also significantly larger in the trigger finger than in the contralateral normal finger (P < 0.05). In 10 of the 11 (91%) surgically treated fingers, successful resolution of triggering without recurrence was achieved after release of the A1 pulley together with the proximal one-third of the A2 pulley. One finger had recurrent triggering, which was successfully treated with complete A2 pulley and partial A3 pulley release. The patient remained asymptomatic after the revision procedure. No other complications were observed. All patients were satisfied with the surgical outcomes and at the most recent follow-up evaluation had returned to full activities.Conclusions: Ultrasonographic measurements in PTF patients suggested that PTF is caused by a size mismatch between the flexor tendon and the area under the A1 pulley. The difference is the result of nodule formation or thickening within one or both of the flexor digitorum superficialis slips. Surgical release of the A1 pulley and of the proximal one-third of the A2 pulley is a very efficient treatment for PTF, yielding satisfactory outcomes that may shorten the duration of symptoms.
Inhibitors of IFN Gene Stimulators (STING) Improve Intestinal Ischemia-Reperfusion Induced Acute Lung Injury by Activating AMPK Signal
Authors: Yang Mei , Ma Yu-Xia , Zhi Ying , Wang Hai-Bin , Zhao Li , Wang Peng-Sheng , Niu Jie-Ting 
Published: February 2022

Abstract
Background: Acute lung injury (ALI) caused by intestinal ischemia-reperfusion is a life-threatening disease. Interferon gene stimulator (STING) is a cytoplasmic DNA sensor, participating in the initiation of inflammatory response. This study aims to establish whether C-176 (STING inhibitor) improves the ALI under intestinal ischemia-reperfusion conditions.Methods: To induce ALI, 72 C57BL/6 mice male were subjected to intestinal ischemia-reperfusion for 90 min. Through intraperitoneal injection, C-176, a selective STING inhibitor was injected 30 minutes before surgical treatment; meanwhile, compound C, an antagonist of adenosine monophosphate-activated protein kinase (AMPK) was administered 30 min after surgery. Based on immunofluorescence and Western blot assays, post-ALI assessments included lung water content (TLW), bronchoalveolar lavage fluid (BALF) protein, H&E staining, Masson staining, pulmonary apoptosis (TUNEL, cleaved caspase-3), and pyroptosis (Gasdermin-D [GSDMD], cleaved caspase-1).Results: C-176 administration significantly attenuated intestinal ischemia-reperfusion-mediated ALI; this was reflected by exasperated TLW and BALF protein, aggravated lung injury score, elevated degree of pulmonary fibrosis, increased TUNEL- and GSDMD-positive cells, as well as upregulated phosphor-AMPK, cleaved caspase-3, and cleaved caspase-1 expression. Moreover, C-176 increased phosphor-AMPK under ALI conditions. Nonetheless, compound C partially reversed these beneficial effects.Conclusion: C-176, a selective STING inhibitor improves intestinal ischemia-reperfusion-mediated ALI, and its underlying mechanism may be associated with AMPK signal activation.
MVA-CoV2-S vaccine candidate confers full protection from SARS-CoV-2 brain infection and damage in susceptible transgenic mice
Authors: Villadiego Javier , García-Arriaza Juan , Ramírez-Lorca Reposo , Cabello-Rivera Daniel , Álvarez-Vergara María I. , Cala-Fernández Fernando , García-Swinburn Roberto , García-Roldán Ernesto , López-Ogáyar Juan L. , Zamora Carmen , Astorgano David , Pérez Patricia , Rosales-Nieves Alicia , Muñoz-Cabello Ana M. , Pascual Alberto , Esteban Mariano , Lopez-Barneo Jose , Toledo-Aral Juan 
Published: February 2022

Abstract
The protective efficacy of vaccines against SARS-CoV-2 infection in the brain is yet unclear. Here, in the susceptible transgenic K18-hACE2 mouse model of severe COVID-19 disease, we report a detailed spatiotemporal description of the SARS-CoV-2 infection and replication in different areas of the brain. Remarkably, SARS-CoV-2 brain replication occurs primarily in neurons, producing important neuropathological alterations such as neuronal loss, incipient signs of neuroinflammation, and vascular damage in SARS-CoV-2 infected mice. Notably, one or two doses of a modified vaccinia virus Ankara (MVA) vector expressing the SARS-CoV-2 spike (S) protein (MVA-CoV2-S) conferred full protection against SARS-CoV-2 cerebral infection, preventing virus replication in all areas of the brain and its associated damage. This protection was maintained even after SARS-CoV-2 reinfection. To our knowledge, this is the first study of a COVID-19 vaccine candidate showing 100% efficacy against SARS-CoV-2 brain infection and damage, reinforcing the use of MVA-CoV2-S as a promising vaccine candidate against SARS-CoV-2/COVID-19, worth to move forward into clinical trials.
Leukocyte Count Predicts Carotid Artery Stenosis in Men With Ischemic Stroke: Sub Study of the Preventive Antibiotics in Stroke Study (Pass)
Authors: Velzen Twan J. , Stolp Jeffrey , Westendorp Willeke F. , Roos Yvo B.W.E.M. , de Beek Diederik van , Nederkoorn Paul J. 
Published: February 2022

Abstract
Background: Inflammation is important in the development of atherosclerosis. Research suggested sex-dependent differences for the value of inflammatory markers for risk stratification of stroke patients with internal carotid artery stenosis (ICAS). We investigated whether leukocytes and thrombocytes were associated with ≥50% ICAS in acute stroke and whether this was sex-dependent.Methods: Patients included in the PASS were evaluated for the predictive value of leukocytes and thrombocytes for ICAS. In PASS patients with ischemic stroke or TIA were randomized between four days of ceftriaxone intravenously or standard stroke care alone. Logistic regression analysis was performed adjusting for NIHSS and other covariates.Results: 2550 patients were included in PASS. 1413 of 2550 patients (55%) were evaluated in this sub study. Female patients showed a mean of 8.55 x 109/L for leukocytes and 259 x 109/L for thrombocytes. Men showed a mean of 8.29 x 109/L for leukocytes and 224 x 109/L for thrombocytes. Multivariate logistic regression analysis showed that leukocytes were independently associated with ICAS ≥50% in male patients (OR 1.094, p=0.008), but not in female patients (OR 1.041, p=0.360). Thrombocytes were not associated with ICAS.Conclusions: We conclude that blood leukocyte count independently predicts ICAS in men after acute stroke, but not in women. Clinical Trial Registration-URL: https://doi.org/10.1186/ISRCTN66140176 Unique identifier: ISRCTN66140176
The Anterior Temporal Cortex in Action
Authors: Knights Ethan , Smith Fraser , Rossit Stephanie 
Published: February 2022

Abstract
Intelligent manipulation of handheld tools marks a major discontinuity between humans and our closest ancestors. Here we identified neural representations about how tools are typically manipulated within left anterior temporal cortex, by shifting a searchlight classifier through whole-brain real action fMRI data when participants grasped 3D-printed tools in ways considered typical for use (i.e., by their handle). These neural representations were automatically evocated as task performance did not require semantic processing. In fact, findings from a behavioural motion-capture experiment confirmed that actions with tools (relative to non-tool) incurred additional processing costs, as would be suspected if semantic areas are being automatically engaged. These results substantiate theories of semantic cognition that claim the anterior temporal cortex combines sensorimotor and semantic content for advanced behaviours like tool manipulation.
Simulations of the Angular Kinetic-Energy Distribution of Halo Weakly Interacting Massive Particles for Directional Dark Matter Detection Experiments
Authors: Shan Chung-Lin 
Published: February 2022

Abstract
In this paper, as the second step of our study on developing data analysis procedures for using 3-dimensional information offered by directional Dark Matter detection experiments in the future, we investigate the patterns of the angular distribution of the Monte Carlo-generated 3-D kinetic energy of halo Weakly Interacting Massive Particles (WIMPs) in different celestial coordinate systems. We will demonstrate the "directionality" of the angular distributions of the 3-D WIMP kinetic energy by both of their annual and diurnal modulations. For readers' reference, the angular distribution patterns of the 3-D WIMP kinetic energy in the "laboratory (location)-dependent" reference frames of several underground laboratories are given in the Appendix.
Assessment of Prunus Rootstock Accessions Using Chloroplast and Nuclear Microsatellites
Authors: Chen Chunxian , Rodriguez-Bonilla Lorraine , Beckman Thomas G. 
Published: February 2022

Abstract
A rootstock collection of Prunus species and hybrids is maintained at the U.S. Department of Agriculture stone fruit breeding program at Byron, GA. We genotyped 66 Prunus rootstock accessions and clones using chloroplast and nuclear microsatellites in this study. Chloroplast microsatellites revealed that the accessions belong to four previously defined maternal lineage groups (MLG-1 to -4) and five new ones (MLG-9 to -13). MLG-1 and -2 share the same chloroplast alleles of ‘Chinese Cling’ peach (Prunus persica) derived scions and American scions and rootstocks related to early European introductions, respectively. MLG-3 included ‘Guardian’ rootstock and its descendants. MLG-4 had a single genotype, ‘Okinawa’, that is the maternal parent of ‘Flordaking’. MLG-9 and MLG-11 to -13 included hybrids with different plums (Prunus salicina, Prunus cerasifera, Prunus tomentosa, or Prunus angustifolia) in their maternal parentage. MLG-10 included hybrids from almond (Prunus. dulcis) in the maternal parentage. The neighbor-joining phylogenetic tree based on nuclear microsatellite genotyping data showed several clusters. Cluster I included only one scion cultivar Elberta from MLG-1. Clusters II, III, and V contained peach accessions mostly in MLG-2. Clusters IV and VI included accessions mostly in MLG-3. Cluster VII included most accessions of plum-peach hybrid origin and those found within MLG-13. Cluster VIII was found to be mixed with different plum-peach hybrids and hybrids from other Prunus species, most of which were found in MLG-10, -11, and -12. Most accessions in Cluster IX were related to plums in MLG-11 and a few accessions in MLG-9.
ATRAVESSAMENTOS NATURAIS NA PRODUÇÃO DE SUBJETIVIDADE AMBIENTAL
Authors: Mazzarino Jane , Scheibe Denise , Petter Bruno , Griebeler Debora 
Published: February 2022

Uma escola pública, uma área verde, um grupo de alunos de 11 e 12 anos e um grupo de pesquisa que tinha como objetivo experienciar possibilidades de sensibilização ambiental baseadas em um método que explora atividades ao ar livre, visando à produção de uma subjetividade ambiental. Estes elementos foram geradores de encontros semanais que duraram três meses, optando-se por avaliar um processo de educação ambiental em continuidade, a fim de se estabelecer um vínculo com o grupo e observar com profundidade processos que os pesquisadores só investigavam em encontros esporádicos. A estratégia do grupo de pesquisa foi baseada no método do Aprendizado Sequencial de Joseph Cornell e na proposta ecosófica de Felix Guattari e suas três ecologias: subjetiva, social e ambiental. O objetivo foi investigar possibilidades de produção de subjetividade ambiental a partir da proposta ecosófica e de um método de educação ambiental ao ar livre. Como elemento conclusivo fundamental consideramos a evidência de que o contato coletivo com a natureza afeta as relações sociais, favorecendo a percepção do outro na sua singularidade. Ou seja, a natureza atua como facilitadora da abertura para o outro. A ecologia social e subjetiva ou mental, no caso em estudo, foram favorecidas pela ecologia do ambiente.
LOCUS DA ESPERANÇA
Authors: Machado da Rosa Lessandro , Gago João , Melo André , Ronald Clemer , Nóbrega Diego , Medeiros Vítor 
Published: February 2022

O Projeto Locus da Esperança surge da participação no concurso de ideias para a realização de um módulo habitacional para contextos de catástrofe. Este concurso foi promovido pelo International Virtual Architectural Design Studio (IVADS) - PROJETANDO on-line 2021, organizado pelo Grupo Projetar/UFRN (Natal, Brasil) em parceria com a FAU/Lisboa na sequência do Seminário 10º Projetar 2021 realizado em Lisboa. Neste contexto, sugeriu-se a criação de um programa/situação fictício como ponto de partida: A Autoridade Nacional de Emergência e Proteção Civil de Portugal e a Defesa Civil do Brasil realizaram uma parceria para buscar soluções em abrigos para situações de catástrofes que pudessem responder às necessidades de ambos os países. Tendo esse cenário, os padrões bases do abrigo poderão ser produzidos centralizadamente pelos governos de cada país e distribuídas às suas respectivas entidades subnacionais, de modo a que cada localidade possa incrementar a solução com materiais de maior disponibilidade e adequação ao clima e situação geográfica em diferentes situações. Por se tratar de um atelier virtual com participantes do Brasil e Portugal foram utilizadas tecnologias que permitissem a realização de reuniões e sessões de trabalho à distância como a plataforma Miro e o Google Meet. O trabalho contou com a participação ativa de membros da UFRN - Lessandro Rosa, André Melo e Vítor Medeiros; da UFPB - Clemer Ronald e Diego Nóbrega; e da FA/ULisboa - João Gago. Para além disto, o projeto foi orientado pela equipa composta pelos professores doutores Heitor Andrade (UFRN); Amélia Panet (UFPB) e Paulo Almeida (FA/ULisboa).