bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 Vaccine Initiation and Dose Completion During the SARS-CoV-2 Delta Variant Surge in the United States, December 2020–October 2021
Authors: Murthy Neil , Saelee Ryan , Patel Murthy Bhavini , Meng Lu , Shaw Lauren , Gibbs-Scharf Lynn , Harris LaTreace , Chorba Terence , Zell Elizabeth 
Published: September 2022

Objectives: In summer 2021, the number of COVID-19–associated hospitalizations in the United States increased with the surge of the SARS-CoV-2 Delta variant. We assessed how COVID-19 vaccine initiation and dose completion changed during the Delta variant surge, based on jurisdictional vaccination coverage before the surge. Methods: We analyzed COVID-19 vaccination data reported to the Centers for Disease Control and Prevention. We classified jurisdictions (50 states and the District of Columbia) into quartiles ranging from high to low first-dose vaccination coverage among people aged ≥12 years as of June 30, 2021. We calculated first-dose vaccination coverage as of June 30 and October 31, 2021, and stratified coverage by quartile, age (12-17, 18-64, ≥65 years), and sex. We assessed dose completion among those who initiated a 2-dose vaccine series. Results: Of 51 jurisdictions, 15 reached at least 70% vaccination coverage before the Delta variant surge (ie, as of June 30, 2021), while 35 reached that goal as of October 31, 2021. Jurisdictions in the lowest quartile of vaccination coverage (44.9%-54.9%) had the greatest absolute (9.7%-17.9%) and relative (18.1%-39.8%) percentage increase in vaccination coverage during July 1–October 31, 2021. Of those who received the first dose during this period across all jurisdictions, nearly 1 in 5 missed the second dose. Conclusions: Although COVID-19 vaccination initiation increased during July 1–October 31, 2021, in jurisdictions in the lowest quartile of vaccination coverage, coverage remained below that of jurisdictions in the highest quartile of vaccination coverage before the Delta variant surge. Efforts are needed to improve access to and increase confidence in COVID-19 vaccines, especially in low-coverage areas.
Evaluation of Motion Segment Size as a New Sensor-based Functional Outcome Measure in Stroke Rehabilitation
Authors: Nam Hyung Seok , Lee Woo Hyung , Seo Han Gil , Smuck Matthew W. , Kim Sungwan 
Published: September 2022

Objective To evaluate a novel parameter, motion segment size (MSS), in stroke patients with upper limb impairment and validate its clinical applicability by correlating results with a standard clinical task-based functional evaluation tool. Methods In this cross-sectional study, patients with hemiplegia and healthy controls equipped with multiple inertial measurement unit (IMU) sensors performed Action Research Arm Test (ARAT) and activities of daily living (ADL) tasks. Acceleration of the wrist and Euler angles of each upper limb segment were measured. The average and maximum MSS, accumulated motion, total performance time, and average motion speed (AMS) were extracted for analysis. Results Data from nine patients and 10 controls showed that the average MSS of forearm supination/pronation and elbow flexion/extension during full ARAT tasks showed a significant difference between patients and controls and a significant correlation with ARAT scores. Conclusions We suggest that MSS may provide clinically relevant information regarding upper limb functional status in stroke patients.
Feeding Performance and Outcomes in Infants With Robin Sequence Undergoing Mandibular Distraction Osteogenesis
Authors: McGhee Heather , Gehle Daniel , Shope Chelsea , Wen Chun-Che , Marston Alexander P , Discolo Christopher , Pecha Phayvanh P 
Published: September 2022

To describe perioperative feeding performance in infants with Robin sequence (RS) who underwent mandibular distraction osteogenesis (MDO). A retrospective study of infants that underwent MDO from May 2010 to December 2019. Tertiary pediatric hospital. A total of 40 patients underwent MDO and 20 met inclusion criteria. Of the included infants, 6 had an associated syndrome and 80% were male. Time to full oral feeds, rate of G-tube placement, and change in weight percentile following MDO. Average oral intake prior to MDO was 22.1% of individual goal feeds. Among the 15 (75%) children that did not require G-tube placement, mean time to full oral feeds after MDO was 11 days ± 5.7 days, with 80% of infants reaching full oral feeds within 2 weeks after extubation. The proportion of G-tube placement in patients with a syndrome was higher than in isolated RS (−0.6; 95% CI: −1.0, −0.2). Mean percentages of weight-for-age percentile decreased during the first 3 months after the procedure. This was followed by a mean upturn in weight starting after the third month after MDO with a recovery to preoperative mean weight-for-age percentiles by 6 months after surgery. This study suggests that infants with RS may achieve full oral feeds despite poor feeding performance before MDO. Infants with syndromic RS are more likely to require G-tube. These findings may be used to inform G-tube discussion and offer a timeline to work toward goal oral feeds for infants with RS after MDO.
The Assessment of the Impact of Training With Various Metacognitive Interventions on the Enhancement of Verbal Fluency in School-Age Children With ADHD
Authors: Kajka Natalia , Kulik Agnieszka 
Published: September 2022

Objective: The aim of this study was to examine whether a 3-month training with the use of the metacognitive strategies would strengthen the executive function related to verbal fluency in children with ADHD. Method: A total of 45 children with ADHD ( M = 10.41; SD = 1.42) participated in a randomized experimental study. They completed the Verbal Fluency Test before and after training. Result: The results of the Wilcoxon test show that the mean number of words spoken by the child increased significantly in the second measurement compared to the first in the Mind Map group ( M = 11.40; SD = 4.03; M = 14.46; SD = 3.99; p = .001). Unfortunately, this data did not apply to the Sketchnoting Group. Verbal regression was noted in the Control Group. Conclusion: The results provide an interesting premise for further research. Perhaps Mind Mapping training can be an effective form of complementary therapy.
Agreement between parent-proxy and child self-report in pediatric hypermobile Ehlers-Danlos syndrome
Authors: Wang You , Clemens Julia L , Muriello Michael , Mu Weiyi , Smith Christy H , Tran Phuong T , Rowe Peter C , Francomano Clair , Kline Antonie D , Bodurtha Joann 
Published: September 2022

Hypermobile Ehlers-Danlos syndrome (hEDS) is a common disorder in children and adolescents that negatively impacts health-related quality of life (HRQOL). It can include chronic pain, fatigue, autonomic dysfunction, and mood problems. The objective of this study was to examine levels of agreement between children and parents in the setting of hEDS and HRQOL. Individuals with hEDS, ages 10-20 years, and their parents were recruited to complete a series of surveys. Instruments included pediatric quality of life generic and multidimensional fatigue scales, Functional Disability Index, Pain-Frequency-Severity-Duration scale, Brief Illness Perception Questionnaire, and Herth Hope Index. Agreement on each measure was evaluated using statistical calculations. Thirty-six parent-child dyads completed the surveys. There were no significant differences between the means of parent and child scores. There was moderate to strong agreement on all survey scores. However, the proportion of dyads with disagreement was relatively high for each individual score. Eighteen dyads disagreed on at least half of the surveys. Body mass index centile and child perception of cognitive fatigue most strongly predicted disagreement in total HRQOL score. Proxy-reporters for children and adolescents with hEDS may agree with their child on average. However, due to significant frequency of clinically important disagreement, information from both children and their parents should be sought whenever possible.
Impact behaviors and damage mechanisms of 2.5D woven composites: Experiment and simulation
Authors: Dong Fang , Yuan Qiong , Liu Jingyan , Qian Kun , Sun Jin , Zhang Diantang 
Published: September 2022

2.5D structures have received attention because of their excellent interlaminar mechanical properties. However, there is a lack of research on impact progressive damage, damage mechanisms and internal damage morphology. This paper investigated the low-velocity impact behavior and damage mechanisms of 2.5D woven carbon/epoxy composites through a couple of numerical-experimental approach. Two different impact energy levels, 15 J/mm and 20 J/mm, were designed for all the samples using drop weight impact equipment. Then Micro-CT was employed to identify the impact damage volumes and damage distribution of 2.5D woven composites. A novel whole-local finite element model was proposed based on the tests results and Micro-CT images. The experimental results indicated that the impact energy has a significant effect on the damage modes of 2.5D woven composite. Moreover, the numerically predicted mechanical curves and damage modes exhibit good consistency with the experimental results. Importantly, the numerical simulation results showed that the damage mode of 2.5D woven composites under impact energies of 15 J/mm was mainly controlled by yarn-matrix debonding. With the increase of impact energy per unit thickness, the dominated failure mode of 2.5D woven carbon/epoxy composites changes from yarn-matrix debonding to delamination and eventually to yarn breakage.
Effect of Leg Half-Squat Training With Blood Flow Restriction Under Different External Loads on Strength and Vertical Jumping Performance in Well-Trained Volleyball Players
Authors: Wang Jiaoqin , Fu Honghao , QiangZhang  , Zhang Ming , Fan Yongzhao 
Published: September 2022

Purpose To examine the effect of blood flow restriction resistance training under different external loads on the muscle strength and vertical jumping performance in volleyball players. Methods 18 well-trained collegiate male volleyball players were randomly divided into 3 groups: high-load resistance training group (HL-RT, 70% 1RM, n = 6), low-load blood flow restriction resistance training group (LL-BFR-RT, 30% 1RM, 50% arterial occlusion, n = 6), and high-load blood flow restriction resistance training group (HL-BFR-RT, 70% 1RM, 50% arterial occlusion, n = 6). Participants performed leg half-squat exercise 3 times per week for 8 weeks. Measurements of Isokinetic peak torque of knee extension and flexion, 1RM leg half-squat, squat jump, and 3 footed take-off were obtained before and after training. A two-way repeated-measures analysis of variance was used to examine differences among the 3 groups and between the 2 testing time (pre-test vs post-test). Results (1) The HL-RT group was significantly greater in muscle strength than that in the LL-BFR-RT group ( P < .05), but no improvement in vertical jumping performance ( P >.05). (2) Improvement in muscle strength and vertical jumping performance was significantly greater in the HL-BFR-RT group than that in the LL-BFR-RT group ( P <.05). (3) The HL-BFR-RT group had greater but not significant improvement in muscle strength and vertical jumping performance than that in the HL-RT group. Conclusions Although increases in muscle strength were observed between training groups, HL-BFR-RT increased not only muscle strength but vertical jumping performance to a greater extent compared to LL-BFR-RT and HL-RT.
Daphnetin Mitigates Ovalbumin-Induced Allergic Rhinitis in Mice by Regulating Nrf2/HO-1 and TLR4/NF-kB Signaling
Authors: Tian Bo , Ma Xin , Jiang Rui 
Published: September 2022

Background Allergic rhinitis (AR) is an inflammatory disorder of nasal mucosa resulting from allergen exposure. Daphnetin (DAP) is a coumarin derivative that has various bioactivities. Nevertheless, its specific function in AR is unclear. Objectives This study is aimed to explore the specific function of DAP in AR. Methods An AR murine model was established by ovalbumin (OVA) induction. Murine sneezing and rubbing behaviors were observed. Hematoxylin-eosin was used for histopathological observation of nasal mucosa. ELISA was utilized for detection of cytokine production in murine serum. Oxidative stress-associated markers were assessed by commercial assay kits. Western blotting was utilized for evaluating protein levels of Toll-like receptor 4 (TLR4) and nuclear factor kappa B (NF-κB) in nasal mucosa. Results DAP alleviated OVA-induced nasal symptoms, inflammatory response and oxidative stress in the AR murine model. DAP activated nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) signaling and inactivated TLR4/NF-κB signaling in murine nasal mucosa. Conclusion DAP mitigates OVA-induced AR in mice by activating Nrf2/HO-1 signaling and inactivating TLR4/NF-κB signaling.
Predicting Health-Related Quality of Life Outcomes Following Major Scoliosis Surgery in Adolescents: A Latent Class Growth Analysis
Authors: Kerr Jack , Abraham Edward , Vandewint Amanda , Bigney Erin , Hebert Jeffrey , Richardson Eden , El-Mughayyar Dana , Chorney Jill , El-Hawary Ron , PORSCHE Study Group  , McPhee Rory , Manson Neil 
Published: September 2022

Study Design Prospective cohort study. Objectives To identify patient trajectories of recovery defined by change in health-related quality of life (HRQOL) following surgery for adolescent idiopathic scoliosis (AIS). To explore possible predictors of trajectory membership. Methods Adolescent patients scheduled to undergo spinal fusion for AIS were enrolled in the Post-Operative Recovery following Spinal Correction: Home Experience (PORSCHE) study. Responses to the Pediatric Quality of Life Inventory–version 4 (PedsQL–4.0) were collected prior to surgery and 4 to 6 weeks, 3, 6, and 12 months post-operatively. Latent class growth analyses identified patient subgroups based on their unique trajectories of physical health (PH) and psychosocial health (PSH) outcomes using the PedsQL–4.0 subscale scores. Predictors included demographic, clinical, and psychosocial factors. Results Data from up to 190 patients were included (87.4% female; mean±SD age = 14.6 ± 1.9 years). Three trajectory subgroups were identified for PH and 4 trajectories were found for PSH, with a majority of patients scoring within the established range of healthy adolescents 12 months post-surgery. Increased child and parent pain catastrophizing, child trait anxiety and previous hospitalizations were associated with poorer PH outcomes, whereas increased child and parent pain catastrophizing, child state and trait anxiety, and parent state and trait anxiety were associated with poorer PSH trajectories. Conclusions The PH and PSH trajectories identified in this study and the factors associated with their membership may inform surgical decision-making for AIS while facilitating patient and family counselling regarding peri-operative recovery and expectations.
Margin Sampling and Survival Outcomes in Oral Cavity and p16‐Positive Oropharyngeal Squamous Cell Carcinoma
Authors: MacKay Colin , Turner Brooke , Bullock Martin , Taylor S. Mark , Trites Jonathan , Corsten Martin , Geldenhuys Laurette , Rigby Matthew H. 
Published: September 2022

ObjectiveTo compare the association of margin sampling technique on survival outcomes in surgically treated cT1‐2 oral cavity and oropharyngeal squamous cell carcinoma.Study DesignA prospective longitudinal cohort study.SettingTertiary care academic teaching hospital in Halifax, Nova Scotia.MethodsAll cases of surgically treated cT1‐2 oral cavity and oropharyngeal cancer undergoing specimen‐oriented margin analysis between January 1, 2017, and December 31, 2018 were analyzed. The specimen‐oriented cohort was compared with a cohort of patients from January 1, 2009, to December 31, 2014, where a defect‐oriented margin sampling protocol was used. Kaplan‐Meier survival curves were used to estimate 2‐year overall survival, disease‐specific survival, local control, and recurrence‐free survival rates in oral cavity and p16‐positive oropharyngeal squamous cell carcinoma. Cox proportional hazards models were used to assess the effect of margin sampling method on disease‐specific survival and local control.ResultsThere was no significant association between margin sampling technique and 2‐year survival outcomes for surgically treated cT1‐2 oral cavity and oropharyngeal squamous cell carcinoma. In the multivariate Cox proportional hazard model, the hazard ratio (HR) of specimen‐oriented sampling was not significantly different for disease‐specific survival (HR, 1.32; 95% CI, 0.3032‐5.727; P =. 713) or local control (HR, 0.4087; 95% CI, 0.0795‐2.099; P =. 284).ConclusionIntraoperative margin sampling method was not associated with a significant change in 2‐year survival outcomes. Despite no effect on survival outcomes, implementation of a specimen‐oriented sampling method has potential for cost avoidance by decreasing the number of re‐resections for positive or close margins.
Novel antimyeloma therapeutic option with inhibition of the HDAC1-IRF4 axis and PIM kinase
Authors: Harada Takeshi , Ohguchi Hiroto , Oda Asuka , Nakao Michiyasu , Teramachi Jumpei , Hiasa Masahiro , Sumitani Ryohei , Oura Masahiro , Sogabe Kimiko , Maruhashi Tomoko , Takahashi Mamiko , Fujii Shiro , Nakamura Shingen , Miki Hirokazu , Kagawa Kumiko , Ozaki Shuji , Sano Shigeki , Hideshima Teru , Abe Masahiro 
Published: September 2022

Abstract
Multiple myeloma (MM) preferentially expands and acquires drug resistance in the bone marrow (BM). We herein examined the role of histone deacetylase 1 (HDAC1) in the constitutive activation of the master transcription factor IRF4 and the prosurvival mediator PIM2 kinase in MM cells. The knockdown or inhibition of HDAC1 by the class I HDAC inhibitor MS-275 reduced the basal expression of IRF4 and PIM2 in MM cells. Mechanistically, the inhibition of HDAC1 decreased IRF4 transcription through histone hyperacetylation and inhibiting the recruitment of RNA polymerase II at the IRF4 locus, thereby reducing IRF4-targeting genes, including PIM2. In addition to the transcriptional regulation of PIM2 by the HDAC1-IRF4 axis, PIM2 was markedly upregulated by external stimuli from BM stromal cells and interleukin-6 (IL-6). Upregulated PIM2 contributed to the attenuation of the cytotoxic effects of MS-275. Class I HDAC and PIM kinase inhibitors cooperatively suppressed MM cell growth in the presence of IL-6 and in vivo. Therefore, the present results demonstrate the potential of the simultaneous targeting of the intrinsic HDAC1-IRF4 axis plus externally activated PIM2 as an efficient therapeutic option for MM fostered in the BM.
Identification of crucial lncRNAs and mRNAs in liver regeneration after portal vein ligation through weighted gene correlation network analysis
Authors: Zhu Yan , Li Zhishuai , Zhang Jixiang , Liu Mingqi , Jiang Xiaoqing , Li Bin 
Published: September 2022

Abstract
Background
Portal vein ligation (PVL)-induced liver hypertrophy increases future liver remnant (FLR) volume and improves resectability of large hepatic carcinoma. However, the molecular mechanism by which PVL facilitates liver hypertrophy remains poorly understood.

Methods
To gain mechanistic insight, we established a rat PVL model and carried out a comprehensive transcriptome analyses of hepatic lobes preserving portal blood supply at 0, 1, 7, and 14-day after PVL. The differentially expressed (DE) long-non coding RNAs (lncRNAs) and mRNAs were applied to conduct weighted gene co-expression network analysis (WGCNA). LncRNA-mRNA co-expression network was constructed in the most significant module. The modules and genes associated with PVL-induced liver hypertrophy were assessed through quantitative real-time PCR.

Results
A total of 4213 DElncRNAs and 6809 DEmRNAs probesets, identified by transcriptome analyses, were used to carry out WGCNA, by which 10 modules were generated. The largest and most significant module (marked in black_M6) was selected for further analysis. Gene Ontology (GO) analysis of the module exhibited several key biological processes associated with liver regeneration such as complement activation, IL-6 production, Wnt signaling pathway, autophagy, etc. Sixteen mRNAs (Notch1, Grb2, IL-4, Cops4, Stxbp1, Khdrbs2, Hdac2, Gnb3, Gng10, Tlr2, Sod1, Gosr2, Rbbp5, Map3k3, Golga2, and Rev3l) and ten lncRNAs (BC092620, AB190508, EF076772, BC088302, BC158675, BC100646, BC089934, L20987, BC091187, and M23890) were identified as hub genes in accordance with gene significance value, module membership value, protein–protein interaction (PPI) and lncRNA-mRNA co-expression network. Furthermore, the overexpression of 3 mRNAs (Notch1, Grb2 and IL-4) and 4 lncRNAs (BC089934, EF076772, BC092620, and BC088302) was validated in hypertrophic liver lobe tissues from PVL rats and patients undergoing hepatectomy after portal vein embolization (PVE).

Conclusions
Microarray and WGCNA analysis revealed that the 3 mRNAs (Notch1, Grb2 and IL-4) and the 4 lncRNAs (BC089934, EF076772, BC092620 and BC088302) may be promising targets for accelerating liver regeneration before extensive hepatectomy.
Incidental finding of elevated pulmonary arterial pressures during liver transplantation and postoperative pulmonary complications
Authors: Joosten Alexandre , Carrier François Martin , Menioui Aïmane , Van der Linden Philippe , Alexander Brenton , Coilly Audrey , Golse Nicolas , Allard Marc-Antoine , Lucidi Valerio , Azoulay Daniel , Naili Salima , Toubal Leila , Moussa Maya , Karam Lydia , Pham Hung , Laukaityte Edita , Amara Youcef , Lanteri-Minet Marc , Samuel Didier , Sitbon Olivier , Humbert Marc , Savale Laurent , Duranteau Jacques 
Published: September 2022

Abstract
Background
In patients with end stage liver disease (ESLD) scheduled for liver transplantation (LT), an intraoperative incidental finding of elevated mean pulmonary arterial pressure (mPAP) may be observed. Its association with patient outcome has not been evaluated. We aimed to estimate the effects of an incidental finding of a mPAP > 20 mmHg during LT on the incidence of pulmonary complications.

Methods
We examined all patients who underwent a LT at Paul-Brousse hospital between January 1,2015 and December 31,2020. Those who received: a LT due to acute liver failure, a combined transplantation, or a retransplantation were excluded, as well as patients for whom known porto-pulmonary hypertension was treated before the LT or patients who underwent a LT for other etiologies than ESLD. Using right sided pulmonary artery catheterization measurements made following anesthesia induction, the study cohort was divided into two groups using a mPAP cutoff of 20 mmHg. The primary outcome was a composite of pulmonary complications. Univariate and multivariable logistic regression analyses were performed to identify variables associated with the primary outcome. Sensitivity analyses of multivariable models were also conducted with other mPAP cutoffs (mPAP ≥ 25 mmHg and ≥ 35 mmHg) and even with mPAP as a continuous variable.

Results
Of 942 patients who underwent a LT, 659 met our inclusion criteria. Among them, 446 patients (67.7%) presented with an elevated mPAP (mPAP of 26.4 ± 5.9 mmHg). When adjusted for confounding factors, an elevated mPAP was not associated with a higher risk of pulmonary complications (adjusted OR: 1.16; 95%CI 0.8–1.7), nor with 90 days-mortality or any other complications. In our sensitivity analyses, we observed a lower prevalence of elevated mPAP when increasing thresholds (235 patients (35.7%) had an elevated mPAP when defined as ≥ 25 mmHg and 41 patients (6.2%) had an elevated mPAP when defined as ≥ 35 mmHg). We did not observe consistent association between a mPAP ≥ 25 mmHg or a mPAP ≥ 35 mmHg and our outcomes.

Conclusion
Incidental finding of elevated mPAP was highly prevalent during LT, but it was not associated with a higher risk of postoperative complications.