bluuebunny/crossref_metadata_2025_split huggingface dataset:
Schwerpunkt Kirchenmitgliedschaft
Authors: Winter-Pfändler Urs 
Published: August 2022

ZusammenfassungDie Kirchen sind mit einem radikalen Umbruch in der Religionslandschaft konfrontiert: Die Bevölkerungsanteile der römisch-katholischen und evangelisch-reformierten Kirche sanken in den letzten Jahrzehnten, während der Anteil an Konfessionslosen stark anstieg. Gleichzeitig haben die Kirchen mit Vertrauensverlusten zu kämpfen. Der vorliegende Beitrag zeichnet diesen Umbruch nach und umreißt die sich daraus ergebenden gesellschaftlichen und persönlichen Konsequenzen (Austrittsneigung). Dazu thematisiert er die Mitgliederbindung der Kirchen, die Rolle des Vertrauens und analysiert Umfragedaten aus den Jahren 1998, 2009 und 2018. Dabei zeigt sich: (a) Die Kirchen haben in der Vergangenheit Vertrauen verloren. Im Vergleich mit anderen wichtigen gesellschaftlichen Akteuren wird ihnen aktuell am wenigsten Vertrauen entgegengebracht. Insbesondere die Konfessionslosen gehen gegenüber den Kirchen zusehends auf Distanz. (b) Der Einsatz der Kirchen für sozial Benachteiligte wird anerkannt. Die Bedeutung der Kirchen im eigenen Leben dagegen ist stark von der persönlichen Religiosität abhängig. (c) Jedes dritte Mitglied der römisch-katholischen (38 %) sowie der evangelisch-reformierten Kirche (37 %) überlegt sich, aus der Kirche auszutreten (Austrittsneigung). Und schließlich (d): Es lassen sich deutliche Zusammenhänge feststellen zwischen den Grössen Austrittsneigung, Religiosität, konfessionelle Zugehörigkeit, Vertrauen in die Kirchen und (in geringerem Maße) Soziodemografie der befragten Personen. Das Vertrauen, welches den Kirchen (z. B. im diakonisch-sozialen Bereich) noch entgegengebracht wird, gilt es zu bewahren und falls möglich auszubauen. Ansonsten droht die Gefahr, dass sich die Trends fortschreiben und die Entfremdung zur Kirche weiterwächst.
Award Winning Scones
Authors: Chevez Agustin 
Published: August 2022

AbstractWhenever I walked into a small country town I looked for ‘award winning’ signs. These were usually written on folding boards standing outside bakeries letting passers-by know they had the best pies, vanilla slices, or scones in town. I trusted these accreditations more than the TripAdvisor Certificate of Excellence stickers on shop windows.
Winds
Authors: Chevez Agustin 
Published: August 2022

AbstractI experienced my fair share of days walking in severe, gusty wind. The weather alert on my phone warned me of peak gusts of over 90 km/h and when it did, I relied on my walking sticks to keep me upright. I also paid extra attention to potential falling branches and even entire trees – gum trees have notoriously shallow roots. Strong wind also made for noticeably longer, or shorter, walking days depending on the wind’s direction and it played a role in whether camping was hard or simply impossible.
El Camino Sisyphus Style
Authors: Chevez Agustin 
Published: August 2022

AbstractEn-route adventures and stunning landscapes along the real Camino have inspired books such as Paulo Coelho’s The Pilgrimage [53], Hollywood movies The Way [54], and even award winning documentaries Walking the Camino [55]. As far as I know, nothing so lofty has come out of the virtual version and I think I know why.
Postcard from Pamplona
Authors: Chevez Agustin 
Published: August 2022

AbstractMy Camino came with extras that were not included in the Sydney pilgrimage: I got postcards. One of these was from when I arrived at Pamplona and, allegedly, I had a go at running with the bulls. A postcard, or better said a digital image of a postcard, arrived by email each time I accumulated the number of kilometres that warranted one.
Your Armchair Pilgrimage
Authors: Chevez Agustin 
Published: August 2022

Abstract“I am changing my answer on boredom, I think you should actually go for that one. I will be processing it obsessively for some time, I assure you.” So read the message from Nora to let me know she had changed her mind. Nora didn’t walk with me to Sydney, but still experienced similar effects with the signposts. I received other messages from locals who also embarked on mini pilgrimages following signposts in their own minds.
On Wilderness, Carnivals, and Foolishness
Authors: Chevez Agustin 
Published: August 2022

AbstractLet’s start our pilgrimage by following one of the most significant signposts of all: the workplace should promote absurdity. Signpost 2 came out of the idea that our capability to be absurd gives us a competitive edge over logic-based algorithms in the future of work. Because of this, absurdity should be nurtured at the places where we work (Signpost 3).
Assessment of hepatic fibrosis and inflammation with look-locker T1 mapping and magnetic resonance elastography with histopathology as reference standard
Authors: von Ulmenstein Sophie , Bogdanovic Sanja , Honcharova-Biletska Hanna , Blümel Sena , Deibel Ansgar R. , Segna Daniel , Jüngst Christoph , Weber Achim , Kuntzen Thomas , Gubler Christoph , Reiner Cäcilia S. 
Published: August 2022

Abstract
Purpose
To compare the diagnostic performance of T1 mapping and MR elastography (MRE) for staging of hepatic fibrosis and grading inflammation with histopathology as standard of reference.

Methods
68 patients with various liver diseases undergoing liver biopsy for suspected fibrosis or with an established diagnosis of cirrhosis prospectively underwent look-locker inversion recovery T1 mapping and MRE. T1 relaxation time and liver stiffness (LS) were measured by two readers. Hepatic fibrosis and inflammation were histopathologically staged according to a standardized fibrosis (F0–F4) and inflammation (A0–A2) score. For statistical analysis, independent t test, and Mann–Whitney U test and ROC analysis were performed, the latter to determine the performance of T1 mapping and MRE for fibrosis staging and inflammation grading, as compared to histopathology.

Results
Histopathological analysis diagnosed 9 patients with F0 (13.2%), 21 with F1 (30.9%), 11 with F2 (16.2%), 10 with F3 (14.7%), and 17 with F4 (25.0%). Both T1 mapping and MRE showed significantly higher values for patients with significant fibrosis (F0-1 vs. F2-4; T1 mapping p < 0.0001, MRE p < 0.0001) as well as for patients with severe fibrosis or cirrhosis (F0-2 vs. F3-4; T1 mapping p < 0.0001, MRE p < 0.0001). T1 values and MRE LS were significantly higher in patients with inflammation (A0 vs. A1-2, both p = 0.01). T1 mapping showed a tendency toward lower diagnostic performance without statistical significance for significant fibrosis (F2-4) (AUC 0.79 vs. 0.91, p = 0.06) and with a significant difference compared to MRE for severe fibrosis (F3-4) (AUC 0.79 vs. 0.94, p = 0.03). For both T1 mapping and MRE, diagnostic performance for diagnosing hepatic inflammation (A1-2) was low (AUC 0.72 vs. 0.71, respectively).

Conclusion
T1 mapping is able to diagnose hepatic fibrosis, however, with a tendency toward lower diagnostic performance compared to MRE and thus may be used as an alternative to MRE for diagnosing hepatic fibrosis, whenever MRE is not available or likely to fail due to intrinsic factors of the patient. Both T1 mapping and MRE are probably not sufficient as standalone methods to diagnose hepatic inflammation with relatively low diagnostic accuracy.
Vorhersage von hydrologischen Abflusskennwerten in unbeobachteten Einzugsgebieten mit Machine Learning
Authors: Klingler Christoph , Feigl Moritz , Borgwardt Florian , Seliger Carina , Schmutz Stefan , Herrnegger Mathew 
Published: August 2022

ZusammenfassungIm Rahmen dieser Arbeit wurden Abflusskennwerte für Hochwasser (MJHQ), Mittelwasser (MQ) sowie Niederwasser (MJNQ, MJNQ7, Q95, Q98) für alle topografischen Einzugsgebiete der österreichischen Oberflächenwasserkörper inklusive der ausländischen hydrologischen Oberlieger-Regionen vorhergesagt. Die Regionalisierung der Abflusskennwerte wurde mit dem Machine-Learning-Modell XGBoost durchgeführt. Zentrale Grundlage für das Training von XGBoost war der LamaH-Datensatz, welcher für 859 beobachtete Einzugsgebiete in Zentraleuropa über 70 aggregierte Einzugsgebietseigenschaften und 15 meteorologische Zeitreihen umfasst. Anthropogene Beeinflussungen wie z. B. Jahresspeicher oder Überleitungen wurden durch zusätzlich erstellte Attribute bei der Vorhersage berücksichtigt. Die Testergebnisse haben gezeigt, dass bei der Vorhersage der Abflusskennwerte in unbeobachteten Einzugsgebieten mit einer Abweichung von rund 20 % zu rechnen ist, wobei diese Schätzung auch stark anthropogen beeinflusste Gebiete beinhaltet. Darüber hinaus wurden auch 90-%-Konfidenzintervalle der Vorhersagen mit einem Quantile-Random-Forest-Modell geschätzt und klassifiziert. Die Ergebnisse werden der Öffentlichkeit in Form von Shapefiles unter https://doi.org/10.5281/zenodo.6523372 kostenlos zur Verfügung gestellt.
Brigatinib in Japanese patients with tyrosine kinase inhibitor-naive ALK-positive non-small cell lung cancer: first results from the phase 2 J-ALTA study
Authors: Sugawara Shunichi , Kondo Masashi , Yokoyama Toshihide , Kumagai Toru , Nishio Makoto , Goto Koichi , Nakagawa Kazuhiko , Seto Takashi , Yamamoto Nobuyuki , Kudou Kentarou , Asato Takayuki , Zhang Pingkuan , Ohe Yuichiro 
Published: August 2022

Abstract
Background
We evaluated the safety and efficacy of the anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor (TKI) brigatinib in Japanese patients with TKI-naive ALK-positive non-small cell lung cancer (NSCLC) from the phase 2, open-label, single-arm, multicenter J-ALTA study.

Methods
In the TKI-naive cohort of J-ALTA, the primary end point was independent review committee (IRC)-assessed 12-month progression-free survival (PFS). Secondary end points included objective response rate (ORR), intracranial response, overall survival (OS), and safety.

Results
The data were cut approximately 12 months after last patient enrollment. Thirty-two patients with ALK TKI-naive ALK-positive NSCLC were enrolled (median age [range], 60.5 [29–85] years; median duration of follow-up, 14.2 [3.2–19.3] months; median treatment duration, 13.8 [0.4–19.3] months). IRC-assessed 12-month PFS was 93.0% (90% confidence interval (CI) 79.2–97.8%); ORR, 96.9% (95% CI 83.8–99.9%), 12-month OS, 96.9% (95% CI 79.8–99.6%), and median OS was not reached. Of five patients with measurable baseline CNS metastases, two had partial intracranial response. The most common treatment-emergent adverse events were increased blood creatine phosphokinase (81%), hypertension (59%), and diarrhea (47%). Grade ≥ 3 adverse events occurred in 91% of patients; pneumonitis was reported in 3 (9%) patients.

Conclusions
In the J-ALTA TKI-naive cohort, brigatinib demonstrated clinically meaningful efficacy consistent with the international phase 3 study. The safety profile in Japanese patients was consistent with previous studies. Brigatinib is an important first-line option for Japanese patients with ALK-positive NSCLC.

Clinical registration
NCT03410108
Required distal mesorectal resection margin in partial mesorectal excision: a systematic review on distal mesorectal spread
Authors: Grüter A. A. J. , van Lieshout A. S. , van Oostendorp S. E. , Ket J. C. F. , Tenhagen M. , den Boer F. C. , Hompes R. , Tanis P. J. , Tuynman J. B. 
Published: August 2022

AbstractBackgroundThe required distal margin in partial mesorectal excision (PME) is controversial. The aim of this systematic review was to determine incidence and distance of distal mesorectal spread (DMS).MethodsA systematic search was performed using PubMed, Embase and Google Scholar databases. Articles eligible for inclusion were studies reporting on the presence of distal mesorectal spread in patients with rectal cancer who underwent radical resection.ResultsOut of 2493 articles, 22 studies with a total of 1921 patients were included, of whom 340 underwent long-course neoadjuvant chemoradiotherapy (CRT). DMS was reported in 207 of 1921 (10.8%) specimens (1.2% in CRT group and 12.8% in non-CRT group), with specified distance of DMS relative to the tumor in 84 (40.6%) of the cases. Mean and median DMS were 20.2 and 20.0 mm, respectively. Distal margins of 40 mm and 30 mm would result in 10% and 32% residual tumor, respectively, which translates into 1% and 4% overall residual cancer risk given 11% incidence of DMS. The maximum reported DMS was 50 mm in 1 of 84 cases. In subgroup analysis, for T3, the mean DMS was 18.8 mm (range 8–40 mm) and 27.2 mm (range 10–40 mm) for T4 rectal cancer.ConclusionsDMS occurred in 11% of cases, with a maximum of 50 mm in less than 1% of the DMS cases. For PME, substantial overtreatment is present if a distal margin of 5 cm is routinely utilized. Prospective studies evaluating more limited margins based on high-quality preoperative magnetic resonance imaging and pathological assessment are required.
Genetic variability of indigenous (Quercus robur L.) and late flushing oak (Quercus robur L. subsp. slavonica (Gáyer) Mátyás) in adult stands compared with their natural regeneration
Authors: Burger Katrin , Gailing Oliver 
Published: August 2022

AbstractSlavonian oak (Quercus robur subsp. slavonica (Gáyer) Mátyás) is currently gaining interest in forestry due to forest restructuring in Germany caused by climate change. Slavonian oaks originating from Croatia have been introduced into Germany mainly in the Münsterland region of North Rhine-Westphalia since the second half of the nineteenth century. They are characterized by their late bud burst, long clear bole, stem straightness and faster height and diameter growth compared to indigenous oaks in Germany. In this study, the genetic differentiation of adult trees and their respective progeny of two Slavonian and two indigenous stands in Hamm-Westtünnen, was evaluated. Genetic diversity and structure were estimated using 23 nuclear simple sequence repeat (SSRs) and 5 maternally inherited chloroplast microsatellite markers (cpSSRs). The mean expected heterozygosity of 0.545 and allelic richness of 6.23 indicate high genetic diversity in the studied populations. The group of progenies (AR = 8.40, Ho = 0.524, He = 0.559, FIS = 0.064) shows similar levels of genetic variation as the adult stands (AR = 8.37, Ho = 0.513, He = 0.554, FIS = 0.075). The genetic differentiation between adult stands and progeny was low (FST = 0.013). Genetic assignment of individuals using STRUCTURE revealed that the studied populations were divided into two clusters. There was no evidence of extensive hybridization or gene flow between Slavonian and native populations, possibly due to the different timing of bud burst of the two taxa.
Eighteen Months of COVID-19 Pandemic Through the Lenses of Self or Others: A Meta-Analysis on Children and Adolescents’ Mental Health
Authors: Raccanello Daniela , Rocca Emmanuela , Vicentini Giada , Brondino Margherita 
Published: August 2022

Abstract
Background
The COVID-19 pandemic can have a serious impact on children and adolescents’ mental health. We focused on studies exploring its traumatic effects on young people in the first 18 months after that the pandemic was declared, distinguishing them also according to the type of informants (self-report and other-report instruments).

Objective
We applied a meta-analytic approach to examine the prevalence of depression, anxiety, posttraumatic stress disorder, and psychological distress among children and adolescents during the COVID-19 pandemic, considering the moderating role of kind of disorder and/or symptom, type of instrument, and continent.

Method
We used PsycINFO, PubMed, and Scopus databases to identify articles on the COVID-19 pandemic, applying the following filters: participants until 20 years of age, peer-review, English as publication language. Inclusion required investigating the occurrence of disorders and/or symptoms during the first 18 months of the pandemic. The search identified 26 publications.

Results
The meta-analysis revealed that the pooled prevalence of psychological disorders and/or symptoms for children and adolescents, who were not affected by mental health disturbances before the outbreak of the COVID-19 pandemic, was .20, 95% CI [.16, .23]. Moreover, we found a moderating role of type of instrument: occurrence was higher for self-report compared to other-report instruments.

Conclusions
The study presented an analysis of the psychological consequences for children and adolescents of the exposure to the COVID-19 pandemic, soliciting further research to identify factors underlying resilience. Notwithstanding limitations such as the small number of eligible articles and the fact that we did not examine the role of further characteristics of the studies (such as participants’ age or design), this meta-analysis is a first step for future research documenting the impact of such an unexpected and devastating disaster like the COVID-19 pandemic.
ACOT7 protects epidermal stem cells against lipid peroxidation
Authors: Zhang Guang , Ma Jiaxu , Wu Zhenjie , Cao Guoqi , Liu Chunyan , Song Ru , Sun Rui , Chen Aoyu , Wang Yibing , Yin Siyuan 
Published: August 2022

AbstractEpidermal stem cells (ESCs) are critical for skin regeneration and repair. Previous studies have shown that ESCs are susceptible to oxidative stress, which in turn leads to lipid peroxidation and affects skin repair. Our study aims to explore how ESCs resist lipid peroxidation. By performing proteomics analysis, we found that the expression of Acyl-CoA thioesterase 7 (ACOT7) was positively correlated with the concentration of transferrin. Overexpression adenovirus vectors of ACOT7 were constructed and transfected into ESCs. Levels of lipid peroxidation by flow cytometry, cell viabilities, and MDA levels were measured. The results revealed that ACOT7 could inhibit lipid peroxidation, reduce the level of malondialdehyde (MDA), and improve the survival rate of ESCs induced by H2O2, Erastin, and RSL3. Our data suggest that ACOT7 has an effect on protecting ESCs against iron-dependent lipid peroxidation.
Changes in biomarkers of exposure and biomarkers of potential harm after 360 days in smokers who either continue to smoke, switch to a tobacco heating product or quit smoking
Authors: Gale Nathan , McEwan Michael , Hardie George , Proctor Christopher J. , Murphy James 
Published: August 2022

AbstractThe aim of this study was to investigate whether biomarkers of exposure (BoE) and potential harm (BoPH) are modified when smokers either continue to smoke or switch from smoking cigarettes to exclusive use of a tobacco heating product (THP) in an ambulatory setting over the period of a year, and to compare any changes with smokers who quit tobacco use completely and with never smokers’ biomarker levels. Participants in this year-long ambulatory study were healthy smokers with a self-reported low intent to quit assigned either to continue smoking or switch to a THP; a group of smokers with a self-reported high intent to quit who abstained from tobacco use; and a group of never smokers. Various BoE and BoPH related to oxidative stress, cardiovascular and respiratory diseases and cancer were assessed at baseline and up to 360 days. Substantial and sustained reductions in BoE levels were found at 360 days for both participants who switched from smoking to THP use and participants who quit smoking, in many cases the reductions being of a similar order for both groups. The never smoker group typically had lower levels of the measured BoEs than either of these groups, and much lower levels than participants who continued to smoke. Several BoPHs were found to change in a favourable direction (towards never smoker levels) over the year study for participants who completely switched to THP or quit, while BoPHs such as soluble intercellular adhesion molecule-1 were found to change in an unfavourable direction (away from never smoker levels) in participants who continued to smoke. Our findings, alongside chemical and toxicological studies undertaken on the THP used in this study, lead to the conclusion that smokers who would have otherwise continued to smoke and instead switch entirely to the use of this THP, will reduce their exposure to tobacco smoke toxicants and as a consequence are reasonably likely to reduce disease risks compared to those continuing to smoke.
Environmental disruptors and testicular cancer
Authors: Faja Fabiana , Esteves Sandro , Pallotti Francesco , Cicolani Gaia , Di Chiano Silvia , Delli Paoli Enrico , Lenzi Andrea , Lombardo Francesco , Paoli Donatella 
Published: August 2022

Abstract
Purpose
Testicular cancer (TC) is the most common malignancy among young adult males. The etiology is multifactorial, and both environmental and genetic factors play an essential role in the origin and development of this tumor. In particular, exposure to environmental endocrine disruptors (EEDs), resulting from industrialization and urbanization, seems crucial both in pre-and postnatal life. However, the lack of long-term studies on a wide caseload and the difficulty in evaluating their toxic effects in vivo make it challenging to establish a causal link. This review aims to discuss the main human epidemiological studies currently available in the literature to define a possible association between these chemicals and TC.

Methods
A comprehensive Medline/PubMed and Embase search was performed, selecting all relevant, peer-reviewed papers in English published from 2002 to January 2022. Other relevant papers were selected from the reference lists.

Results
To date, literature evidence is limited due to the scarcity and heterogeneity of human studies and shows controversial data, highlighting the complexity of the topic. However, most human epidemiological studies seem to point toward a correlation between EEDs exposure and TC.

Conclusion
Although the molecular mechanisms are not yet fully understood, the role of EEDs in TC onset is plausible, but several factors, such as the individual genetic background, the exposure time, and the complex mechanism of action of these chemicals, do not allow defining the causal link with certainty and make further studies necessary to investigate this complex topic.