bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of active edible coatings based on fish gelatin enriched with Moringa oleifera extract: Application in fish (Mustelus mustelus) fillet preservation
Authors: Mezhoudi Maram , Salem Ali , Abdelhedi Ola , Fakhfakh Nahed , Mabrouk Mahmoud , Khorchani Touhami , Debeaufort Frederic , Jridi Mourad , Zouari Nacim 
Published: July 2022

AbstractAn edible coating was developed using gelatin extracted from the skin of gray triggerfish (Balistes capriscus) and applied to the fillet of the smooth‐hound shark (Mustelus mustelus). Moringa oleifera leaf extract was added to gelatin coating solution to improve its preservative properties. The phenolic profiles and antioxidant and antibacterial activities of M. oleifera extracts were determined. Phenolic acids constituted the largest group representing more than 77% of the total compounds identified in the ethanol/water (MOE/W) extract, among which the quinic acid was found to be the major one (31.48 mg/g extract). The MOE/W extract presented the highest DPPH• scavenging activity (IC50 = 0.53 ± 0.02 mg/ml) and reducing (Fe3+) power (EC0.5 = 0.57 ± 0.02 mg/ml), as well as interesting inhibition zones (20–35 mm) for the most tested strains. Coating by 3% of gelatin solution significantly reduced most deterioration indices during chilled storage, such as malondialdehyde (MDA), total volatile basic nitrogen (TVB‐N), weight loss, pH, and mesophilic, psychrophilic, lactic, and H2S‐producing bacterial counts. Interestingly, coating with gelatin solution containing MOE/W extract at 20 μg/ml was more effective than gelatin applied alone. Compared with the uncoated sample, gelatin‐MOE/W coating reduced the weight loss and MDA content by 26% and 70% after 6 days of storage, respectively. Texture analysis showed that the strength of uncoated fillet increased by 46%, while the strength of fillet coated with gelatin‐MOE/W only increased by 12% after 6 days of storage. Fish fillet coated with gelatin‐MOE/W had the highest sensory scores in terms of odor, color, and overall acceptability throughout the study period.
Loss of exosomal miR‐34c‐5p in cancer‐associated fibroblast for the maintenance of stem‐like phenotypes of laryngeal cancer cells
Authors: Wang Mei , Zhuoma Ciwang , Liu Xiaojin , Huang Qiang , Cai Guoyu , Sang Ge , Zhou Liang , Du Huaidong , Wu Chunping 
Published: July 2022

AbstractBackgroundCancer‐associated fibroblasts (CAFs) reconstitute cancer stemness. This study aims to investigate whether the loss of CAF‐derived exosomal miR‐34c‐5p contributes to the maintenance of stem‐like properties of laryngeal squamous cell carcinoma (LSCC).MethodsExosomes from primarily cultured CAFs and paired normal fibroblasts (NFs) were collected and identified. The differential expression of exosomal miR‐34c‐5p between CAFs and NFs was detected by next‐generation sequencing. In vitro and in vivo assays were performed to examine the effects of miR‐34c‐5p on the maintenance of stem‐like properties.ResultsMiR‐34c‐5p expression is significantly reduced in CAF‐derived exosomes. In vitro and in vivo assays revealed that exosomal miR‐34c‐5p can regulate the stem‐like properties of LSCC cells, such as proliferation, invasion, sphere and plate colony formation, chemoresistance, tumorigenicity in nude mice, as well as the expression of cancer stem cell genes.ConclusionsLoss of miR‐34c‐5p in CAF‐derived exosomes contributes to the maintenance of stem‐like phenotypes of LSCC.
Rhesus rotavirus receptor‐binding site affects high mobility group box 1 release, altering the pathogenesis of experimental biliary atresia
Authors: Mohanty Sujit K. , Donnelly Bryan , Temple Haley , Mowery Sarah , Poling Holly M. , Meller Jaroslaw , Malik Astha , McNeal Monica , Tiao Greg 
Published: July 2022

Abstract
Biliary atresia (BA) is a neonatal inflammatory cholangiopathy that requires surgical intervention by Kasai portoenterostomy to restore biliary drainage. Even with successful portoenterostomy, most patients diagnosed with BA progress to end‐stage liver disease, necessitating a liver transplantation for survival. In the murine model of BA, rhesus rotavirus (RRV) infection of neonatal mice induces an inflammatory obstructive cholangiopathy that parallels human BA. The model is triggered by RRV viral protein (VP)4 binding to cholangiocyte cell‐surface proteins. High mobility group box 1 (HMGB1) protein is a danger‐associated molecular pattern that when released extracellularly moderates innate and adaptive immune response. In this study, we investigated how mutations in three RRV VP4‐binding sites, RRVVP4‐K187R (sialic acid‐binding site), RRVVP4‐D308A (integrin α2β1‐binding site), and RRVVP4‐R446G (heat shock cognate 70 [Hsc70]‐binding site), affects infection, HMGB1 release, and the murine model of BA. Newborn pups injected with RRVVP4‐K187R and RRVVP4‐D308A developed an obstruction within the extrahepatic bile duct similar to wild‐type RRV, while those infected with RRVVP4‐R446G remained patent. Infection with RRVVP4‐R446G induced a lower level of HMGB1 release from cholangiocytes and in the serum of infected pups. RRV infection of HeLa cells lacking Hsc70 resulted in no HMGB1 release, while transfection with wild‐type Hsc70 into HeLa Hsc70‐deficient cells reestablished HMGB1 release, indicating a mechanistic role for Hsc70 in its release. Conclusion: Binding to Hsc70 contributes to HMGB1 release; therefore, Hsc70 potentially serves as a therapeutic target for BA.
Introduction to endodontic diseases and their treatment in companion animals
Authors: McFadzean Annabel 
Published: July 2022

Background: Endodontically diseased teeth are a common finding in clinical practice, with treatment depending on the duration of the injury, the stage of development of the tooth, and the type of tooth. Endodontic therapy eliminates oral pain and retains tooth functionality, and has decreased surgical complications compared to extraction. It is important that practitioners are aware of this therapy and can advise clients on why their pet's teeth should be treated and the treatment options available.Aim of the article: This article reviews the endodontic anatomy of a tooth, and discusses different types of endodontic procedures, as well as their indications in companion animal practice. This will enable a deeper understanding of this specific dental pathology and help you to communicate the significance of treating these conditions to the client.
Label‐free laser spectroscopy for respiratory virus detection: A review
Authors: Kistenev Yury V. , Das Anubhab , Mazumder Nirmal , Cherkasova Olga P. , Knyazkova Anastasia I. , Shkurinov Alexander P. , Tuchin Valery V. , Lednev Igor K. 
Published: July 2022

AbstractInfectious diseases are among the most severe threats to modern society. Current methods of virus infection detection based on genome tests need reagents and specialized laboratories. The desired characteristics of new virus detection methods are noninvasiveness, simplicity of implementation, real‐time, low cost and label‐free detection. There are two groups of methods for molecular biomarkers' detection and analysis: (i) a sample physical separation into individual molecular components and their identification, and (ii) sample content analysis by laser spectroscopy. Variations in the spectral data are typically minor. It requires the use of sophisticated analytical methods like machine learning. This review examines the current technological level of laser spectroscopy and machine learning methods in applications for virus infection detection.
Concordance of B‐ and T‐cell responses to SARS‐CoV‐2 infection, irrespective of symptoms suggestive of COVID‐19
Authors: Österdahl Marc F. , Christakou Eleni , Hart Deborah , Harris Ffion , Shahrabi Yasaman , Pollock Emily , Wadud Muntaha , Spector Tim D. , Brown Matthew A. , Seow Jeffrey , Malim Michael H. , Steves Claire J. , Doores Katie J. , Duncan Emma L. , Tree Timothy 
Published: July 2022

AbstractThis study assessed T‐cell responses in individuals with and without a positive antibody response to SARS‐CoV‐2, in symptomatic and asymptomatic individuals during the COVID‐19 pandemic. Participants were drawn from the TwinsUK cohort, grouped by (a) presence or absence of COVID‐associated symptoms (S+, S−), logged prospectively through the COVID Symptom Study app, and (b) anti‐IgG Spike and anti‐IgG Nucleocapsid antibodies measured by ELISA (Ab+, Ab−), during the first wave of the UK pandemic. T‐cell helper and regulatory responses after stimulation with SARS‐CoV‐2 peptides were assessed. Thirty‐two participants were included in the final analysis. Fourteen of 15 with IgG Spike antibodies had a T‐cell response to SARS‐CoV‐2‐specific peptides; none of 17 participants without IgG Spike antibodies had a T‐cell response (χ2: 28.2, p < 0.001). Quantitative T‐cell responses correlated strongly with fold‐change in IgG Spike antibody titer (ρ = 0.79, p < 0.0001) but not to symptom score (ρ = 0.17, p = 0.35). Humoral and cellular immune responses to SARS‐CoV‐2 are highly correlated. We found no evidence of cellular immunity suggestive of SARS‐CoV2 infection in individuals with a COVID‐19‐like illness but negative antibodies.
Rerupture and wound complications following Achilles tendon repair: A systematic review
Authors: Shoap Seth , Backer Henrik C. , Freibott Christina E. , Ferrer Xavier E. , Polzer Hans , Turner Vosseller James 
Published: July 2022

AbstractDespite the relatively high frequency of Achilles ruptures, there is no general consensus on the optimal treatment method. A general trend toward more patients being treated nonoperatively has emerged recently with the advent of functional rehabilitation. However, much of the recent data on this subject has been highly variable. This systematic review focused on Achilles tendon rupture (ATR) treatment outcomes, with a focus on rerupture and complication rates. This systematic review specifically focused on articles regarding ATR treatment that also included rerupture and complication rates. Treatments were divided into three categories: open minimally invasive, open standard, and nonoperative. Bivariate analyses were performed to compare complication and rerupture rates among pairs of treatment options, as well as between early weight bearing versus immobilization. There was significantly higher complications for minimally invasive compared to nonoperative treatment (risk ratio [RR] = 4.4154; p < 0.05), lower complication rates for minimally invasive compared to open treatment (RR = 0.3231; p < 0.05), and higher complications for open standard compared to nonoperative treatment (RR = 5.6350; p < 0.001). There were significantly lower rerupture rates in minimally invasive compared to nonoperative treatment (RR = 0.4085; p < 0.001), a significantly lower rerupture rate in nonoperative treatment compared to open treatment (RR = 0.2282; p < 0.001), and no significant difference in rerupture rates when comparing minimally invasive to open standard treatment. We found that operative treatment is associated with fewer reruptures and more complications than a nonoperative approach. Minimally invasive surgery appears to be associated with a lower rate of complications than open operative treatment.
Travelers' pro‐environmental behaviors in the Hyperloop context: Integrating norm activation and AIDA models
Authors: Kang Sung‐Eun 
Published: July 2022

AbstractThis study combines the Norm Activation model (NAM) with the Attention‐Interest‐Desire‐Action model (AIDA) to explain the effect of Hyperloop videos on potential travelers' pro‐environmental behaviors. Using PLS‐SEM, the study's results indicate that each construct of NAM (problem awareness, ascribed responsibility, and personal norm), together with attention, interest, and desire, explains 75% of the variance in pro‐environmental behavioral intentions. The study's findings also indicate that a promotional video can lead to a significant positive change in pro‐environmental travel behaviors and enhance potential travelers' intentions to use Hyperloop services as an eco‐friendly travel option. Furthermore, mediation analysis shows that desire is a strong mediator for connecting the two frameworks.
A laboratory examination of risky sexual behavior among female sexual trauma survivors
Authors: Mahoney Colin T. , Lawyer Steven R. , Pemberton Shelby E. , Marchant Kaitlyn M. 
Published: July 2022

AbstractSexual violence against women is highly prevalent on college campuses. Survivors of sexual violence often engage in coping strategies such as risky sexual behavior. The present study used a behavioral task to measure sexual risk‐taking following experiences of positive or negative affect and an emotion suppression experimental manipulation. Sexually active adult female undergraduates (N = 175) completed measures of sexual traumatization and affective experiences as well as an autobiographical recall task and a delay discounting task for hypothetical sexual outcomes. Half of the participants (n = 87) were asked to suppress their emotional response to the autobiographical recall task. The findings indicate that sexual traumatization had a significant effect on risky sexual decision‐making, F(1, 167) = 23.27, p < .001, ηp2 = .12, but affective condition, F(1, 167) = .57, p = .451, and emotion suppression, F(1, 167) = .69, p = .412, exhibited no significant associations with sexual risk‐taking. These findings suggest other factors may underlie the association between sexual trauma and risky sexual behavior, but further research is warranted.
Reversible Active Switching of Fano and Fabry–Pérot Resonances by Electrochromic Operation
Authors: Chen Jian , Li Yaowu , Zhang Taoyang , Zha Xiuling , Tang Xueqing , Mu Xinyang , Sun Peiyan , Song Ge , Cong Shan , Chen Qin , Zhao Zhigang 
Published: July 2022

AbstractResonances are ubiquitous in modern photonics, with the more familiar Fano and Fabry–Pérot resonators as key components of sophisticated optical devices with unique properties. However, the fundamental drawback of these devices is the difficulty in altering the resonance‐related features of the underlying optical structures postfabrication. This study investigates an active electrochromic tungsten oxide (WO3)‐based reconfigurable photonic structure with reversible switching between the Fano and Fabry–Pérot (F–P) resonances. This remarkable resonance switching occurs as a result of a change in the WO3 film optical indices (n, k) via Li+ intercalation/deintercalation, which can be inferred from the spectral response or dynamic reflected colors. When the bottom Ag layer's thickness is decreased from 130 to 10 nm, a semitransparent structure with unique optical properties emerges. The F–P resonant structure reflects and transmits different colors before Li+ intercalation, while the Fano resonant structure reflects and transmits the same color after Li+ intercalation. Along with these unique optical properties, a trans‐reflective filter and beam splitter filter are also developed based on the reversible electrochromism of a fixed optical configuration.
Advanced Multifunctional Wound Dressing Hydrogels as Drug Carriers
Authors: Farokhi Mehdi , Mottaghitalab Fatemeh , Babaluei Mercedeh , Mojarab Yasamin , Kundu Subhas C. 
Published: July 2022

AbstractSkin injuries, especially chronic wounds, remain a significant healthcare system problem. The number of burns, diabetic patients, pressure ulcers, and other damages is also growing, particularly in elderly populations. Several investigations are pursued in designing more effective therapeutics for treating different wound injuries. These efforts have resulted in developing multifunctional wound dressings to improve wound repair. For this, preparing multifunctional dressings using various methods has provided a new attitude to support effective skin regeneration. This review focuses on the recent developments in designing multifunctional hydrogel dressings with hemostasis, adhesiveness, antibacterial, and antioxidant properties.
Benzotriazole‐Based Nonfused Ring Acceptors for Efficient and Thermally Stable Organic Solar Cells
Authors: Han Daehee , Lim Chulhee , Phan Tan Ngoc‐Lan , Kim Youngkwon , Kim Bumjoon J. 
Published: July 2022

AbstractNonfused ring acceptors (NFRAs) have attracted significant attention for nonfullerene organic solar cells (OSCs) owing to their chemical tunability and facile synthesis. In this study, a benzotriazole‐based NFRA with chlorinated end groups (Triazole‐4Cl) is developed to realize highly efficient and thermally stable NFRA‐based OSCs; an analogous NFRA with nonchlorinated end groups (Triazole‐H) is synthesized for comparison. Triazole‐4Cl film exhibits the high‐order packing structure and the near‐infrared absorption capability, which are advantageous in charge transport and light harvesting of the resulting OSCs. In particular, the strong crystalline behavior of Triazole‐4Cl results in enhanced self‐aggregation, leading to high charge carrier mobility. Owing to these properties, a PBDB‐T (polymer donor):Triazole‐4Cl OSC demonstrates a high short‐circuit current, fill factor, and power conversion efficiency (PCE = 10.46%), outperforming a PBDB‐T:Triazole‐H OSC (PCE = 7.65%). In addition, the thermal stability of a PBDB‐T:Triazole‐4Cl OSC at an elevated temperature of 120 °C exceeds that of a PBDB‐T:Triazole‐H OSC. This is mainly attributed to the significantly higher cold crystallization temperature of Triazole‐4Cl (205.9 °C). This work provides useful guidelines for the design of NFRAs to achieve efficient and thermally stable NFRA‐based OSCs.
Device‐Assisted and Neuromodulatory Therapies for Parkinson's Disease: A Network Meta‐Analysis
Authors: Rajan Roopa , Garg Kanwaljeet , Srivastava Achal. K , Singh Manmohan 
Published: July 2022

AbstractBackgroundDevice‐assisted and neuromodulatory therapies are the standard of care for Parkinson's disease (PD) with disabling motor complications. We aimed to compare and rank the currently available advanced therapies for PD on patient relevant outcomes.MethodsWe searched various databases for randomized controlled trials that studied subthalamic nucleus deep brain stimulation (STN‐DBS), globus pallidus interna (GPi) DBS, pallidotomy, subthalamotomy, continuous subcutaneous apomorphine infusion (CSAI), or intrajejunal levodopa infusion (IJLI), in patients with PD and motor complications. Primary outcome was the quality of life (QOL) at 6 months. Secondary outcomes included Unified Parkinson's Disease Rating Scale III and II, ON time, OFF time, levodopa equivalent daily doses, and adverse events (AE). Data were pooled using a Bayesian network meta‐analysis, summarized as mean difference (MD) with 95% credibility intervals (CrI) and visualized in forest plots/league tables. Surface under the cumulative ranking curve plots determined the ranking probability.ResultsWe identified 6745 citations and included 26 trials. STN‐DBS (MD, −8.0; 95% CrI, −11, −5.8), GPi‐DBS (MD, −7.1; 95% CrI, −11, −2.9), and IJLI (MD, −7.0; 95% CrI, −12, −1.8) led to better QOL than medical therapy alone, without significant differences among them. STN‐DBS had the highest probability of being ranked the best treatment for QOL (79.6%), followed by IJLI (63.5%) and GPi‐DBS (62.8%).ConclusionsIn advanced PD, STN‐DBS alleviates more patient and clinician relevant outcomes, followed by GPi‐DBS and IJLI. In resource limited settings, unilateral pallidotomy may improve motor symptoms and activities of daily living, although overall QOL may not be improved. © 2022 International Parkinson and Movement Disorder Society.
Maternal food‐avoidance diets and dietary supplements during breastfeeding
Authors: Nordhagen Live S. , Løfsgaard Vibeke S. , Småstuen Milada C. , Glavin Kari , Carlsen Kai‐Håkon , Carlsen Monica Hauger , Granum Berit , Gubrandsgard Malén , Haugen Guttorm , Hedlin Gunilla , Jonassen Christine M. , Nordlund Björn , Rehbinder Eva Maria , Rudi Knut , Saunders Carina M. , Skjerven Håvard O. , Staff Anne Cathrine , Söderhäll Cilla , Vettukattil Riyas , Aaneland Hilde , Lødrup Carlsen Karin C. 
Published: July 2022

AbstractAimsTo identify maternal food‐avoidance diets and dietary supplement use during breastfeeding, and to explore factors associated with food avoidance diets.DesignA prospective mother–child birth cohort study.MethodsElectronic questionnaires were answered by 1,462 breastfeeding mothers 6 months postpartum in the Preventing Atopic Dermatitis and Allergies in Children (PreventADALL) study from 2014–2016. Demographic and antenatal factors were analysed for associations with food avoidance diets in 1,368 women by multiple logistic regression.ResultsOverall, 289 breastfeeding women (19.8%) avoided at least one food item in their diet, most commonly cow's milk in 99 women (6.8%). Foods were most often avoided due to conditions in the child, maternal factors or lifestyle choice. The odds for food avoidance diets were 2.1 (95% CI: 1.3, 3.4) for food allergy (presumed or diagnosed) and 19.4 (5.4, 70.1) for celiac disease in the mother. Dietary supplements were reported by nearly 80%, most commonly cod liver oil.
Preparation and characterization of cellulose nanofiber/melamine–urea–formaldehyde composite aerogels for thermal insulation applications
Authors: Guo Limin , Wang Fei , Li Hanyin 
Published: July 2022

AbstractThe inherent flammability and low strength of pure cellulose aerogels limit their use in several applications. In this study, novel cellulose nanofibers/synthetic polymeric composite aerogels with excellent flame retardancy and increased strength were prepared under aqueous conditions with an eco‐friendly freeze‐drying and post‐curing process. This composite combined a rigid melamine–urea–formaldehyde network and pentaerythritol phosphate melamine salt as an inorganic flame retardant. The latter is positively charged; hence, it could react with 2,2,6,6‐tetramethylpiperidine‐1‐oxyl‐oxidized cellulose nanofibers, which are negatively charged, by the charge neutralization of pentaerythritol. The resultant composite aerogels showed excellent flame‐retardant properties, an increased compressive modulus (up to 73.1 kPa), and low densities (8.75–10.7 mg/cm3). The composite aerogels also exhibited a limiting oxygen index as high as 30.2% and a remarkable decrease in the fire indices. Therefore, we believe that the developed composite aerogel demonstrates potential as a lightweight composite thermal insulation for construction applications.
Influence of biochar and carbon black on natural rubber mixture properties
Authors: Lubura Jelena , Kojić Predrag , Ikonić Bojana , Pavličević Jelena , Govedarica Dragan , Bera Oskar 
Published: July 2022

AbstractA biochar made by hydrothermal carbonisation treatment of hardwood waste biomass was compared with traditional carbon black (CB) filler and their impact on the electricity consumption of the rubber mixture, vulcanisation and mechanical properties was examined. Two sets of experiments were conducted, following the same procedure and recipe and using different contents (parts per hundred) of biochar or CB as a filler (0, 10, 20, 30, 40 and 50 phr). The low content of different fillers (up to 20 phr) showed a similar electricity consumption for rubber mixing. Further increase of filler content caused a superior impact on energy consumption value for prepared rubber mixtures with CB. An influence of filler type and content on the vulcanisation properties (maximum and minimum torque, scorch time and cure rate index) was detected. With regard to hardness values, tensile strength, elongation at break and tensile stress were affected by the different reinforcing agents and their content. The assessed data revealed that CB as a filler might potentially be replaced with environmentally friendly and sustainable fillers up to 30 phr, enabling similar rubber vulcanisation and mechanical properties. The overall outcome of this study emphasised the significance of the results obtained for strict environmental protection demands in the rubber industry. © 2022 Society of Industrial Chemistry.