bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor growth monitoring in breast cancer xenografts: A good technique for a strong ethic
Authors: Rodallec Anne , Vaghi Cristina , Ciccolini Joseph , Fanciullino Raphaelle , Benzekry Sebastien 
Published: September 2022

Purpose
Although recent regulations improved conditions of laboratory animals, their use remains essential in cancer research to determine treatment efficacy. In most cases, such experiments are performed on xenografted animals for which tumor volume is mostly estimated from caliper measurements. However, many formulas have been employed for this estimation and no standardization is available yet.

Methods
Using previous animal studies, we compared all formulas used by the scientific community in 2019. Data were collected from 93 mice orthotopically xenografted with human breast cancer cells. All formulas were evaluated and ranked based on correlation and lower mean relative error. They were then used in a Gompertz quantitative model of tumor growth.

Results
Seven formulas for tumor volume estimation were identified and a statistically significant difference was observed among them (ANOVA test, p < 2.10−16), with the ellipsoid formula (1/6 π × L × W × (L + W)/2) being the most accurate (mean relative error = 0.272 ± 0.201). This was confirmed by the mathematical modeling analysis where this formula resulted in the smallest estimated residual variability. Interestingly, such result was no longer valid for tumors over 1968 ± 425 mg, for which a cubic formula (L x W x H) should be preferred.

Main findings
When considering that tumor volume remains under 1500mm3, to limit animal stress, improve tumor growth monitoring and go toward mathematic models, the following formula 1/6 π × L × W x (L + W)/2 should be preferred.
Perinatal outcome of twin pregnancies among mothers who gave birth in Adama Hospital Medical College, Central Ethiopia
Authors: Beyene Mekonen , Abdo Komicha Meyrema , Hussien Hassen , Abdulwahed Anwar , Hassen Tahir Ahmed , Roba Kedir Teji 
Published: September 2022

Introduction
Twin pregnancy carries a high risk of pregnancy-related complications including adverse perinatal outcomes. Although evidence from international studies indicated an increased risk of adverse perinatal outcomes in twin pregnancies, little is known about the adverse perinatal outcomes in twin pregnancies and associated factors in Ethiopia. The purpose of this study was, therefore, to estimate the incidence of twin pregnancies and related-adverse perinatal outcomes and identify factors associated with adverse perinatal outcomes in twin pregnancies in Ethiopia.

Methods
A hospital-based retrospective cross-sectional study was conducted among 322 mothers who gave twin birth at Adama Hospital Medical College between 08 July 2015 and 07 June 2017. In this study, the adverse perinatal outcome was defined as the presence of any of the following main conditions: low birth weight, preterm birth, stillbirth, low Apgar Scores, mal-presentation, Admission to neonatal Intensive Care Unit (NICU), and early neonatal deaths. The data were analyzed using SPSS version 20.0. Multivariable logistic regression was conducted to identify factors associated with adverse perinatal outcome at 95% CI or P-value of less than 0.05.

Result
Of 10,850 births recorded in the hospital, 354 births were twins and 322 of these paired records had complete perinatal information. One hundred ninety-nine (61.8%) of the 322 paired birth records had at least one adverse perinatal outcome on one or both twins. Low birth weight was the most common perinatal outcome followed by preterm birth. After adjusting for confounding factors, younger maternal age (AOR = 4.1, 95% CI; 1.3, 12.5) and not having ultrasound scan during antenatal care (AOR = 2.0, 95% CI: 1.2, 3.1) were significantly associated with adverse perinatal outcomes.

Conclusion
The incidence of adverse perinatal outcome in twin pregnancies was high, that is, in 61.8% of twin births, there was at least one adverse perinatal outcome on one or both twins. Moreover, younger maternal age at birth and not having an ultrasound scan during antenatal care were found to be strong predictors for the observed high incidence of adverse perinatal outcomes.
Hypotension after general anesthesia induction using remimazolam in geriatric patients: Protocol for a double-blind randomized controlled trial
Authors: Yokose Masashi , Takaki Ryuki , Mihara Takahiro , Saigusa Yusuke , Yamamoto Natsuhiro , Masui Kenichi , Goto Takahisa 
Published: September 2022

Introduction
In geriatric patients, hypotension is often reported after general anesthesia induction using propofol. Remimazolam is a novel short-acting sedative. However, the incidence of hypotension after general anesthesia induction using remimazolam in geriatric patients remains unclear. This study aims to compare the incidence of hypotension associated with remimazolam and propofol in patients aged ≥80 years.

Methods
This single-center, double-blind, randomized, two-arm parallel group, standard treatment-controlled, interventional clinical trial will include 90 patients aged ≥80 years undergoing elective surgery under general anesthesia who will be randomized to receive remimazolam or propofol for induction. The primary outcome is the incidence of hypotension after general anesthesia induction, occurring between the start of drug administration and 3 min after intubation. We define hypotension as mean blood pressure <65 mmHg. The primary outcome will be analyzed using the full analysis set. The incidence of hypotension in the two groups will be compared using the Mantel-Haenszel χ2 test. Subgroup analysis of the primary outcome will be performed based on the Charlson comorbidity index, clinical frailty scale, hypertension in the ward, and age. Secondary outcomes will be analyzed using the Fisher’s exact test, Student’s t test, and Mann–Whitney U test, as appropriate. Logistic regression analysis will be performed to explore the factors associated with the incidence of hypotension after anesthesia induction.

Discussion
Our trial will determine the efficacy of remimazolam in preventing hypotension and provide evidence on the usefulness of remimazolam for ensuring hemodynamic stability during general anesthesia induction in geriatric patients.

Trial registration
The study has been registered with UMIN Clinical Trials Registry (UMIN000042587), on June 30, 2021.
Desplazamiento interno forzado en México por violencia e inseguridad en regiones mineras
Authors: Muñoz Kelly G. , Llano Manuel , Ruiz Naxhelli 
Published: September 2022

El desplazamiento interno forzado es un fenómeno que se deriva de condiciones de violencia intensa, a partir de diferentes hechos circunstanciales victimizantes, que tiene como consecuencia una movilidad en el territorio de grupos sociales en condiciones de extrema vulnerabilidad. Este artículo es un estudio descriptivo exploratorio de la relación entre desplazamiento forzado y la presencia de las explotaciones mineras metálicas en diferentes regiones del país, en las fases de exploración, producción, desarrollo, postergación o cierre. El estudio aborda el desplazamiento a través de un proxy, compuesto por la emigración a nivel municipal asociada con altas tasas de incidencia de delitos de alto impacto. Muestra los valores de correlación de ambos aspectos a través de una regionalización del país, con la finalidad de observar de manera significativa la presencia y distribución espacial de ambos fenómenos. Describe las particularidades que existen en cada una de estas regiones a nivel nacional, de acuerdo al tipo de la actividad minera y de los perfiles de violencia que se presentan en éstas.
En este trabajo se abordan los problemas metodológicos asociados a la identificación y asociación espacial de estos fenómenos, a partir de la información disponible en diversas fuentes estadísticas, así como bases de datos oficiales y de la sociedad civil. El uso de estas fuentes permite explorar los retos relacionados con el estudio y visualización del desplazamiento interno forzado, que pueden servir de insumo para la aplicación de marcos normativos y de atención para la prevención de este fenómeno.
Intervensi Pekerjaan Sosial: Efektivitas Pemberdayaan disabilitas Tuli melalui Program Kewirausahaan
Authors: Fani Ayu Lestari  , Muhtadi Muhtadi 
Published: September 2022

This study aims to describe the effectiveness of the Gertakin Institute's Intervention in empowering deaf disabilities through the entrepreneurial movement. This study is part of the program evaluation that has been carried out by Gertakin to encourage self-reliance in entrepreneurship. This study uses qualitative methods through observation and interview techniques. The subject of the informant in the study was a Deaf Disability who became a member and participated in the entrepreneurship program implemented by GERKATIN. The results of the study indicate that there are 3 important aspects in the effort to empower deaf people to encourage independence. Deaf people have the ability to make adjustments, have good quality work/products, and have job satisfaction because of the ability to self-actualize for entrepreneurship. This finding illustrates that opportunities, intervention efforts and empowerment of deaf persons are important in order to provide space for actualization so that social functioning and independence of deaf disabilities can be well maintained.
Keywords: Social Work Intervention, deaf disability empowerment, social entrepreneurship

Studi ini bertujuan untuk mendiskripsikan tentang efektivitas Intervensi Lembaga Gertakin dalam melalukukan upaya pemberdayaan terhadap disabilitas tuli melalui gerakan kewirausahaan. Kajian ini bagian dari evaluasi program yang telah dilakukan Gertakin untuk mendorong kemandirian dalam berwirausaha.. Penelitian ini menggunakan metode kualitatif melalui teknik observasi dan wawancara. Subjek informan dalam penelitian adalah Disabilitas Tuli yang menjadi anggota dan mengikuti program kewirausahaan yang dilaksanakan oleh GERKATIN. Hasil penelitian menunjukkan bahwa terdapat 3 aspek penting dalam upaya memberdayakan kaum disabilitas tuli untuk mendorong kemandirian. Para disabilitas tuli memiliki kemampuan dalam melakukan upaya penyesuaian diri, memiliki kualitas kerja/produk yang baik, dan memiliki kepuasan kerja karena kemampuan mengaktualisasi diri untuk berwirausaha. Temuan ini memberikan gambaran bahwa bahwa kesempatan, upaya intervensi dan pemberdayaan terhadap para disabilitas tuli penting dalam rangka memberikan ruang aktualisasi, sehingga keberfungsian sosial dan kemandirian disabilitas tuli bisa terjaga dengan baik.
Kata Kunci: Intervensi Pekerjaan Sosial, pemberdayaan disabilitas tuli, kewirausahaan sosial
Results of surgical treatment of the thoracic spinal nerve tumors: a retrospective analysis
Authors: Vasilyev I. A. , Shirokikh I. V. , Eliseenko I. A. , Shershever A. S. , Stupak V. V. 
Published: September 2022

Objective. To analyze clinical and morphological features of neurogenic hourglass tumors in the thoracic spine and their impact on outcomes of treatment through posterior surgical approaches.Material and Methods. The results of surgical treatment of 295 patients with tumors growing from the nerve roots of the thoracic spinal cord were studied. In 63 (21 %) of them, tumors of the spinal nerves were diagnosed. The vast majority of neoplasms were represented by Grade 1 neuromas – in 57 (90 %) patients, Grade 1 neurofibromas were found in 3 (5 %) patients, and High-grade malignant tumors – in 3 (5 %). Intracanal neoplasms were found in 42 (66.7 %) cases and intraextravertebral (hourglass) – in 21 (33.3 %).Results. Microsurgical removal of tumor was performed using two types of low-traumatic surgical approaches: 1) posterior median approach – in 56 (89.0 %) cases, of which hemilaminectomy was performed in 36 (64.4%) cases, interlaminectomy – in 15 (26.8 %) cases, and laminectomy – in 5 (8.1 %) cases; 2) paravertebral approach – in 7 (11.0 %) out of 63 cases with partial facetotomy or facetectomy and resection of part of the head and upper or lower edge of the rib at the same level. Tumors were removed totally in 56 (88.9 %) patients and subtotally – in 7 (11.1%). Intracanal tumors were removed totally in 40 (95.2 %) patients. A similar totality was achieved in removal of 16 (76.2 %) of hourglass neurinomas. Surgical interventions performed in the early postoperative period improved the functional state of patients: the Karnofsky Performance Scale (KPS) index increased from 70–80 to 90 %, the VAS pain score decreased from 5–6 to 2 points. Good clinical outcomes were achieved in 42 (66.7 %) patients, satisfactory – in 17 (27.0 %), and unsatisfactory – in 6 (6.3 %). Twenty nine patients had symptoms of myelopathy, complete regression of which occurred in 3 (10.3 %) cases, partial – in 9 (34.6 %), in 13 (50.0 %) cases they remained at the preoperative level, and in 4 (15.4 %) – worsened.Conclusion. The use of modern neurointroscopy, microsurgical techniques and low-traumatic posterior surgical approaches for resection of tumors of the spinal nerve roots in the thoracic spine provides good clinical outcomes of treatment in the early postoperative period. The existing hourglass tumor in the thoracic spine reduces the likelihood of its total removal when performing a low-traumatic posterior approach.
Pertanggungjawaban Pidana Korporasi Atas Pencemaran Lingkungan Hidup
Authors: Wijaya Hendra , Santoso Budi , Azhar Muhamad 
Published: September 2022

Abstract The purpose of this research is to identify juridical arrangements regarding the crime of environmental pollution in Indonesia and to specifically examine the responsibility for environmental pollution crime according to Law No. 32 of 2009 concerning Environmental Protection and Management. By using normative legal research methods, it can be concluded, that: 1. How environmental pollution is carried out by Corporations, 2. In terms of criminal liability for environmental pollution, the parties that can be accounted for are not only individuals, but also corporation such as for example a business entity. This is confirmed in Articles 116-118 of Law No. 32 of 2009. Keywords : environment; responsibility; corporation; pollution AbstrakTujuan dilakukannya penelitian ini adalah untuk mengidentifikasi mengenai pengaturan yuridis mengenai tindak pidana pencemaran lingkungan di Indonesia dan untuk secara spesifik mengkaji mengenai pertanggungjawaban atas tindak pidana pencemaran lingkungan menurut Undang-undang No 32 Tahun 2009 Tentang Perlindungan dan Pengelolaan Lingkungan Hidup. Dengan menggunakan metode penelitian hukum normatif, maka dapat disimpulkan, bahwa : 1. Bagaimana terjadinya pencemaran lingkungan hidup yang dilakukan oleh Korporasi, 2. Dalam hal pertanggungjawaban pidana tindak pidana pencemaran lingkungan hidup, pihak-pihak yang dapat dipertanggungjawabkan tidak hanya orang perorangan, tetapi juga korporasi seperti contohnya suatu badan usaha. Hal ini dipertegas dalam Pasal 116-118 Undang-Undang No. 32 Tahun 2009. Kata kunci : lingkungan hidup; pertanggungjawaban; korporasi; pencemaran
Asas Keseimbangan Sebagai Indikator Keadilan di Dalam Perjanjian Baku
Authors: Setiawan Muhammad Tommy , Busro Achmad , Prasetyo Mujiono Hafidh 
Published: September 2022

Everyone has the freedom to enter into any agreement provided that it does not conflict with applicable laws, morality and public order. Franchisee candidates are given the freedom to choose to accept or reject the agreement (take it or leave it) by not participating in determining its contents. This article discusses the issue of the benchmarks of fairness in the franchise agreement between the franchisor and the franchisee and the legal consequences of injustice that occurs in the agreement. The method used is normative juridical. The results of the study found that the agreement was legal according to law, as for the contents of the contract which were considered unfair by some parties, this did not cause the cancellation of the contract application. The parties who have agreed and agreed to the contract (take it) and also signed the contract so that they must bear the legal consequences that arise, except when an element of fraud and oversight is found, then the other party gets a wrong or wrong understanding of the contract, both parties should have good intentions to solve the problem.Keywords: Standard Agreement; Franchisee; JusticeAbstrakSetiap orang memiliki kebebasan untuk mengadakan segala perjanjian dengan ketentuan tidak bertentangan dengan undang-undang yang berlaku, kesusilaan dan ketertiban umum. Calon Franchisee diberikan kebebasan untuk memilih menerima atau menolak perjanjian tersebut dengan tidak ikut serta menentukan isinya. Artikel ini membahas persoalan tentang tolok ukur keadilan di dalam perjanjian franchise antara franchisor dan franchisee serta akibat hukum atas ketidakdilan yang terjadi dalam perjanjian tersebut. Metode yang digunakan adalah yuridis normatif. Hasil penelitian diketahui bahwa perjanjian tersebut sah menurut hukum, adapun terkait isi kontrak yang dinilai tidak adil oleh sebagian pihak, hal tersebut tidak menyebabkan dibatalkannya permohonan kontrak. Para pihak yang telah sepakat dan menyetujui kontrak (take it) serta ikut bertandatangan sehingga harus menanggung konsekuensi hukum yang ditimbulkan, kecuali ketika ditemukan adanya unsur penipuan dan kekhilafan, maka pihak lain mendapat pemahaman yang keliru atau salah tentang kontrak seharusnya kedua belah beri’tikad baik guna menyelesaikan persoalan tersebut.Kata kunci : Perjanjian Baku; Franchisee; Keadilan
Peran PPAT Terhadap Aspek Perpajakan Dalam Transaksi Jual Beli Tanah Dan Bangunan
Authors: Maghribi Muhamad Fadli , Ispriyarso Budi 
Published: September 2022

Taxes defined by significant source of state income in economic development, one of which is land and building taxes. Land Deed Making Official is public official who is given the authority to make authentic deeds regarding certain legal actions regarding land rights or ownership rights over apartment units. In certain legal acts whose deeds are made by the PPAT, there are conditions, one of which is that the PBB of the last year has been paid. This provision has major effect in increasing orderly tax payments. Based on these things, the problems in this study are: What is the role of the Land Deed Making Official (PPAT) in taxation aspect in the sale and purchase of land and buildings. The purpose of this research is to determine how the role of PPAT in collecting tax aspects in buying and selling land and buildings. The methods in this research is normative juridical approach with statutory approach and conceptual approach. The research are reesulting; The role of PPAT in tax collection is very large for the state in order to increase the source of state revenue which is not the main authority of a PPAT itself.Keywords: Tax; Land and building tax; Land deed making official. AbstrakPajak didefinisikan sebagai sumber pemasukan negara yang cukup penting dalam pembangunan ekonomi, salah satunya adalah Pajak Bumi dan Bangunan . Pejabat Pembuat Akta Tanah adalah pejabat umum yang diberikan kewenangan untuk membuat akta otentik mengenai perbuatan hukum tertentu mengenai hak atas tanah atau hak milik atas satuan rumah susun. Di dalam perbuatan hukum tertentu yang aktanya dibuat oleh PPAT terdapat syarat salah satunya bahwa PBB tahun terakhir sudah lunas. Ketentuan tersebut berpengaruh besar dalam meningkatkan tertib bayar pajak. Berdasarkan hal-hal tersebut maka permasalahan yang diteliti dalam penelitian ini adalah : Bagaimana peran dari Pejabat Pembuat Akta Tanah (PPAT) dalam aspek perpajakan dalam transaksi jual beli tanah dan bangunan. Tujuan penulisan penelitian ini adalah untuk mengetahui bagaimana peran dari PPAT dalam pemungutan aspek perpajakan dalam transaksi jual beli tanah dan bangunan. Metode yang digunakan dalam penelitian ini adalah metode pendekatan yuridis normatif dengan metode pendekatan perundang-undangan dan pendekatan konsep. Penelitian ini menghasilkan; Peran PPAT dalam pemungutan pajak sangatlah besar kepada negara dalam rangka meningkatkan sumber penerimaan negara yang sebenarnya bukan merupakan kewenangan seorang PPAT itu sendiri.Kata kunci: Pajak; PBB; PPAT.
Jak zmniejszyć asymetrię informacji na rynku crowdfundingu udziałowego w Polsce?
Authors: Trzebiński Artur A. 
Published: September 2022

Przedmiotem rozważań podjętych w artykule jest rynek crowdfundingu udziałowego w Polsce, w szczególności sposoby i zakres komunikowania o przeprowadzanych emisjach. Celem artykułu jest wskazanie i ocena działań podjętych przez uczestników polskiego rynku crowdfundingu, które mają zmniejszać asymetrię informacji. Uwaga została skupiona przede wszystkim na rozwiązaniach zawartych w unijnym rozporządzeniu Parlamentu Europejskiego i Rady (UE) 2020/1503 w sprawie europejskich dostawców usług finansowania społecznościowego dla przedsięwzięć, którego implementacja do krajowego porządku prawnego ma być przeprowadzona do listopada 2022 r. W badaniu sprawdzono, jakie efekty przynoszą działania podjęte przez ustawodawcę, platformy crowdfundingowe, Komisję Nadzoru Finansowego i Związek Przedsiębiorstw Finansowych w Polsce w zakresie zmniejszenia nierównowagi informacyjnej. W tym celu wykorzystano analizę aktów prawnych i analizę przyczynowo-skutkową. Wyniki badań wskazują, że podejmowane działania przez różne podmioty, które mają wpływ na krajowy rynek crowdfundingu udziałowego, powodują zmniejszanie asymetrii informacji. Jest to istotne ze względu na to, że wzrasta wartość i liczba przeprowadzanych emisji oraz rośnie liczba zaangażowanych w kampanie crowdfundingowe inwestorów.
Frost
Authors: Graf Martin , Laskowski Lukas , Papsdorf Florian , Sold Florian , Gremmelspacher Roland , Naumann Felix , Panse Fabian 
Published: September 2022

"Bad" data has a direct impact on 88% of companies, with the average company losing 12% of its revenue due to it. Duplicates - multiple but different representations of the same real-world entities - are among the main reasons for poor data quality, so finding and configuring the right deduplication solution is essential. Existing data matching benchmarks focus on the quality of matching results and neglect other important factors, such as business requirements. Additionally, they often do not support the exploration of data matching results.
To address this gap between the mere counting of record pairs vs. a comprehensive means to evaluate data matching solutions, we present the Frost platform. It combines existing benchmarks, established quality metrics, cost and effort metrics, and exploration techniques, making it the first platform to allow systematic exploration to understand matching results. Frost is implemented and published in the open-source application Snowman, which includes the visual exploration of matching results, as shown in Figure 1.