bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between pleth variability index and ultrasonic inferior vena cava-collapsibility index in parturients with twin pregnancies undergoing cesarean section under spinal anesthesia
Authors: Zhang Huiying , Yuan Hongmei , Yu Huiling , Zhang Yue , Feng Shanwu 
Published: August 2022

Abstract
Background
To explore the correlation and consistency of non-invasive pleth variability index (PVI) combined with ultrasonic measurement of inferior vena cava-collapsibility index (IVC-CI) in parturients with twin pregnancies undergoing cesarean section under spinal anesthesia.

Methods
Forty-seven twin pregnancies women undergoing elective cesarean section were selected. The ASA score was rated as I–II, aged from 18 to 45 years. Spinal anesthesia was performed at L3–4. PVI and IVC-CI, general data (BMI, gestational weeks, operation duration, blood loss), MAP, temperature sensory block level and adverse reactions were recorded at baseline (T1) and completion of testing the level of spinal anesthesia (T2).

Results
The correlation coefficient analysis of baseline IVC-CI% and PVI revealed that the Pearson's coefficient was 0.927, > 0.4. Thus, pre-anesthesia IVC-CI% had a strong correlation with PVI, with R2 of 85.69%. The correlation coefficient analysis of post-anesthesia IVC-CI% and PVI revealed that the Pearson's coefficient was 0.904, > 0.4. Thus, post-anesthesia IVC-CI% had a strong correlation with PVI, with R2 of 81.26%.

Conclusion
PVI is strongly consistent with ultrasound measurement of IVC-CI twin pregnancies, which can be used as a valuable index for predicting the volume in parturients with twin pregnancies undergoing cesarean section under spinal anesthesia.
Trial registration This study was registered on ClinicalTrials.gov with clinical trial registration number of ChiCTR2200055364 (08/01/2022).
Selective isolation of extracellular vesicles from minimally processed human plasma as a translational strategy for liquid biopsies
Authors: Fortunato Diogo , Giannoukakos Stavros , Giménez-Capitán Ana , Hackenberg Michael , Molina-Vila Miguel A. , Zarovni Nataša 
Published: August 2022

Abstract
Background
Intercellular communication is mediated by extracellular vesicles (EVs), as they enclose selectively packaged biomolecules that can be horizontally transferred from donor to recipient cells. Because all cells constantly generate and recycle EVs, they provide accurate timed snapshots of individual pathophysiological status. Since blood plasma circulates through the whole body, it is often the biofluid of choice for biomarker detection in EVs. Blood collection is easy and minimally invasive, yet reproducible procedures to obtain pure EV samples from circulating biofluids are still lacking. Here, we addressed central aspects of EV immunoaffinity isolation from simple and complex matrices, such as plasma.

Methods
Cell-generated EV spike-in models were isolated and purified by size-exclusion chromatography, stained with cellular dyes and characterized by nano flow cytometry. Fluorescently-labelled spike-in EVs emerged as reliable, high-throughput and easily measurable readouts, which were employed to optimize our EV immunoprecipitation strategy and evaluate its performance. Plasma-derived EVs were captured and detected using this straightforward protocol, sequentially combining isolation and staining of specific surface markers, such as CD9 or CD41. Multiplexed digital transcript detection data was generated using the Nanostring nCounter platform and evaluated through a dedicated bioinformatics pipeline.

Results
Beads with covalently-conjugated antibodies on their surface outperformed streptavidin-conjugated beads, coated with biotinylated antibodies, in EV immunoprecipitation. Fluorescent EV spike recovery evidenced that target EV subpopulations can be efficiently retrieved from plasma, and that their enrichment is dependent not only on complex matrix composition, but also on the EV surface phenotype. Finally, mRNA profiling experiments proved that distinct EV subpopulations can be captured by directly targeting different surface markers. Furthermore, EVs isolated with anti-CD61 beads enclosed mRNA expression patterns that might be associated to early-stage lung cancer, in contrast with EVs captured through CD9, CD63 or CD81. The differential clinical value carried within each distinct EV subset highlights the advantages of selective isolation.

Conclusions
This EV isolation protocol facilitated the extraction of clinically useful information from plasma. Compatible with common downstream analytics, it is a readily implementable research tool, tailored to provide a truly translational solution in routine clinical workflows, fostering the inclusion of EVs in novel liquid biopsy settings.
Improving estimates of the ionosphere during geomagnetic storm conditions through assimilation of thermospheric mass density
Authors: Fernandez-Gomez Isabel , Kodikara Timothy , Borries Claudia , Forootan Ehsan , Goss Andreas , Schmidt Michael , Codrescu Mihail V. 
Published: August 2022

AbstractDynamical changes in the ionosphere and thermosphere during geomagnetic storm times can have a significant impact on our communication and navigation applications, as well as satellite orbit determination and prediction activities. Because of the complex electrodynamics coupling processes during storms, which cannot be fully described with the sparse set of thermosphere–ionosphere (TI) observations, it is crucial to accurately model the state of the TI system. The approximation closest to the true state can be obtained by assimilating relevant measurements into physics-based models. Thermospheric mass density (TMD) derived from satellite measurements is ideal to improve the thermosphere through data assimilation. Given the coupled nature of the TI system, the changes in the thermosphere will also influence the ionosphere state. This study presents a quantification of the changes and improvement of the model state produced by assimilating TMD not only for the thermosphere density but also for the ionosphere electron density under storm conditions. TMD estimates derived from a single Swarm satellite and the Coupled Thermosphere Ionosphere Plasmasphere electrodynamics (CTIPe) physics-based model are used for the data assimilation. The results are presented for a case study during the St. Patricks Day storm 2015. It is shown that the TMD data assimilation generates an improvement of the model’s thermosphere density of up to 40% (measured along the orbit of the non-assimilated Swarm satellites). The model’s electron density during the course of the storm has been improved by approximately 8 and 22% relative to Swarm-A and GRACE, respectively. The comparison of the model’s global electron density against a high-quality 3D electron density model, generated through assimilation of total electron content, shows that TMD assimilation modifies the model’s ionosphere state positively and negatively during storm time. The major improvement areas are the mid-low latitudes during the storm’s recovery phase.
Graphical Abstract
Do the Footwear Profiles and Foot-Related Problems Reported by Netball Players Differ Between Males and Females?
Authors: Kirk Maddison M. , Mattock Joshua P. M. , Coltman Celeste E. , Steele Julie R. 
Published: August 2022

Abstract
Introduction
We explored the footwear profiles and foot-related problems reported by netball players and whether these differed between males and females.

Methods
Two thousand nine hundred and twenty-five amateur, sub-elite and elite netball players (men n = 279; women n = 2646; age 26.4 ± 10.0 years) completed a custom-designed online survey with questions related to netball experience, current netball footwear habits and history of foot-related problems. Footwear profiles and foot-related problems were considered in logistic regressions against sex and competition level to ascertain significant relationships (p < 0.05) and predictive values (odds ratio).

Results
Although 80.4% of respondents reported wearing netball-specific shoes, females were 13.2 times more likely to wear netball-specific shoes than males. Foot-related problems and foot pain were reported by 84.3% and 56.8% of netball players, respectively; with blisters, ankle sprain/strains and calluses being most common. Although women were significantly more likely to suffer from foot-related problems than men, males were significantly more likely to believe their foot pain was caused by the footwear they wore for netball.

Conclusion
The high prevalence of foot-related problems and pain reported by all netball players suggests that the shoes players are currently wearing for netball are not meeting the requirements of players, particularly regarding fit, comfort and functionality. As male netball players have significantly different footwear profiles to female players, men are likely to require netball-specific footwear that differs to the netball-specific shoes designed for female players.
Feasibility of an Audit and Feedback Intervention to Facilitate Journal Policy Change Towards Greater Promotion of Transparency and Openness in Sports Science Research
Authors: Hansford Harrison J. , Cashin Aidan G. , Bagg Matthew K. , Wewege Michael A. , Ferraro Michael C. , Kianersi Sina , Mayo-Wilson Evan , Grant Sean P. , Toomey Elaine , Skinner Ian W. , McAuley James H. , Lee Hopin , Jones Matthew D. 
Published: August 2022

AbstractObjectivesTo evaluate (1) the feasibility of an audit-feedback intervention to facilitate sports science journal policy change, (2) the reliability of the Transparency of Research Underpinning Social Intervention Tiers (TRUST) policy evaluation form, and (3) the extent to which policies of sports science journals support transparent and open research practices.MethodsWe conducted a cross-sectional, audit-feedback, feasibility study of transparency and openness standards of the top 38 sports science journals by impact factor. The TRUST form was used to evaluate journal policies support for transparent and open research practices. Feedback was provided to journal editors in the format of a tailored letter. Inter-rater reliability and agreement of the TRUST form was assessed using intraclass correlation coefficients and the standard error of measurement, respectively. Time-based criteria, fidelity of intervention delivery and qualitative feedback were used to determine feasibility.ResultsThe audit-feedback intervention was feasible based on the time taken to rate journals and provide tailored feedback. The mean (SD) score on the TRUST form (range 0–27) was 2.05 (1.99), reflecting low engagement with transparent and open practices. Inter-rater reliability of the overall score of the TRUST form was moderate [ICC (2,1) = 0.68 (95% CI 0.55–0.79)], with standard error of measurement of 1.17. However, some individual items had poor reliability.ConclusionPolicies of the top 38 sports science journals have potential for improved support for transparent and open research practices. The feasible audit-feedback intervention developed here warrants large-scale evaluation as a means to facilitate change in journal policies.Registration: OSF (https://osf.io/d2t4s/).
Hypertensive attack induced by dexamethasone during induction of anesthesia in a patient with an adrenal pheochromocytoma: a case report
Authors: Kurita Shuichiro , Kamiya Yoshinori 
Published: August 2022

Abstract
Background
Dexamethasone is used perioperatively as an antiemetic for postoperative nausea and vomiting. Evidence and mechanism linking dexamethasone and hypertensive attack of pheochromocytoma during anesthesia have not been reported.

Case description
We report a case of a hypertensive attack during anesthetic induction immediately after dexamethasone administration in a 35-year-old woman with adrenal pheochromocytoma. Approximately 2 min after the anesthetic drugs and dexamethasone were administered, her arterial blood pressure suddenly increased from 143/79 to 243/116 mmHg during manual mask ventilation. Since tracheal intubation had not been performed yet, dexamethasone could be a causative agent of hypertensive episodes. The surgery and anesthesia were uneventful. She was admitted to the intensive care unit to have her blood pressure controlled subsequently.

Conclusions
Dexamethasone should be used with caution in patients with adrenal pheochromocytoma on account of the risk of hypertensive attacks.
Relationship between psychiatric symptoms and activities of daily living in patients undergoing hemodialysis
Authors: Matsunaga Yusuke , Takahashi Hiroki , Suzuki Yuta , Yamamoto Shohei , Imamura Keigo , Yoshikoshi Shun , Uchida Juri , Nakajima Takuya , Fukuzaki Narumi , Harada Manae , Matsuzawa Ryota , Yoshida Atsushi , Ichikura Kanako , Fukase Yuko , Murayama Norio , Murase Hanako , Tagaya Hirokuni , Matsunaga Atsuhiko 
Published: August 2022

Abstract
Background
Accurately identifying the factors contributing to decline in activities of daily living (ADL) is important for preventing such decline in patients undergoing hemodialysis (HD). We studied the prevalence and number of overlapping psychiatric symptoms (depressive symptoms, apathy, and sleep disturbance) in patients undergoing HD and examined the relationship between psychiatric symptoms and ADL.

Methods
The study utilized a cross-sectional research design. The sample included 203 outpatients (median age: 69 years) undergoing stable HD treatment three times a week. Patient characteristics, including age, sex, body composition, dialysis vintage, primary kidney disease, comorbidity, and nutritional status, were collected from patients’ medical records. Functional status was assessed based on the self-reported questionnaire that combined five basic and eight instrumental ADL items. Usual walking speed was used as an index of physical function. Additionally, the short version of the Center for Epidemiologic Studies Depression Scale was used to assess depressive symptoms. Further, apathy and sleep disturbance were assessed using the Motivation Score and the Athens Insomnia Scale, respectively.

Results
Overall, 59 (29.1%) patients demonstrated depressive symptoms, 100 (49.3%) reported apathy, 83 (40.9%) had sleep disturbance, 31 (15.3%) had three overlapping psychiatric symptoms, 43 (21.2%) had two overlapping psychiatric symptoms, 63 (31.0%) had only one symptom, and 66 (32.5%) had no psychiatric symptoms. Multiple logistic regression analysis showed that having two or three overlapping psychiatric symptoms was independently and significantly associated with ADL (functional status of 13 points for the ADL maintenance group, and of < 13 points for the ADL decline group, respectively), even after adjusting for patient characteristics and walking speed (odds ratio: 2.74, 95% confidence interval: 1.12–6.69, reference; no psychiatric symptoms).

Conclusion
The present study clarified that the overlapping symptoms, including depressive symptoms, apathy, and sleep disturbance, were independently associated with ADL decline in patients undergoing HD. It is useful to examine not only depressive symptoms but also other symptoms such as apathy and sleep disturbance to elucidate factors associated with deteriorated ADL in chronic patients. Our findings provide a strong basis for targeted interventions to prevent functional dependence in the HD population.
Person-centered climate from the perspective of hemodialysis patients and nurses working in hemodialysis units
Authors: Abdolsattari Simin , Ghafourifard Mansour , Parvan Kobra 
Published: August 2022

Abstract
Background
Person-centered care (PCC) is considered an important component of high-quality care in hemodialysis units. Hemodialysis patients and nurses may have different perceptions of person-centeredness in hemodialysis units. The present study aimed to assess the PCC from the perspective of hemodialysis patients and nurses working in the hemodialysis unit.

Methods
This cross-sectional study was performed on 200 patients and 71 nurses working in two hemodialysis units. Data were collected using a demographic questionnaire, person-centered climate questionnaire-patient version (PCQ-P), and person-centered climate questionnaire-staff version (PCQ-S). Data were analyzed by SPSS software (ver. 24) using ANOVA and independent t-tests.

Results
The mean score of person-centered climate from the patients' view was 81.49 ± 7.14 (Possible score: 17–102). Independent t-test showed that the mean total score of PCQ-P in patients undergoing hemodialysis in the Imam Reza Hospital (82.26 ± 7.09) was more than those undergoing hemodialysis in the Sina Hospital (78.60 ± 6.61) (P < 0.05). The mean score of the safety subscale showed a statistically significant difference between the two hemodialysis centers (P < 0.05). The mean total score of PCQ-S from the nurses' view was 66.86 ± 8.07 out of 84. The mean score of the everydayness subscale showed a statistically significant difference between nurses working in two hemodialysis units (P < 0.05).

Conclusion
Although the results showed an acceptable score in the person-centered climate questioner, it needs some improvements in the fields of safety and everydayness. The environment of the hemodialysis unit could limit or enhance the implementation of person-centered processes.
Sex-differences in excess death risk during the COVID-19 pandemic: an analysis of the first wave across Italian regions. What have we learned?
Authors: Rizzi Silvia , Strozza Cosmo , Zarulli Virginia 
Published: August 2022

AbstractIn this commentary, we bring together knowledge on sex-differences in excess death during the first wave of the COVID-19 pandemic in Italy, one of the most hit European countries. We zoom into Italian regions to account for the spatial gradient of the spread of the virus. Analyses of excess death by sex during the COVID-19 pandemic have been possible thanks to weekly mortality data released by national statistical offices, mainly in developed countries. The general finding is that males up to 75 years old have been suffering more excess death compared to females. However, the picture is less clear-cut at older ages. During previous epidemics, such as SARS, Swine Flu, and MERS, studies are limited and produce scattered, non-conclusive evidence. Knowledge of the sex-pattern of susceptibility to mortality from virulent respiratory diseases and its interplay with age could improve crisis management during future epidemics and pandemics. National statistical offices should provide weekly mortality data with spatial granularity, disaggregated by sex and age groups, to allow for such analyses.
Investigation of gender differences in stillbirths in Italian regions at the turn of the nineteenth century
Authors: Ruiu Gabriele , Pozzi Lucia , Raftakis Michail , Breschi Marco 
Published: August 2022

AbstractData quality issues have hindered the analysis of the determinants of stillbirths in the years following Italian unification. By exploiting panel data techniques to take into account the possible effect of stillbirth misreporting, this paper investigates the relationship between seasonal agricultural workload and the number of male and female stillbirths in the Italian regions at the turn of the twentieth century (1883–1913). We found that although stillbirth rates were lower for females, agricultural workload seasonality had a more substantial effect for them. We suggest that this finding may be rationalised through the adaptive sex ratio adjustment hypothesis.
Outbreak of cutaneous anthrax associated with handling meat of dead cows in Southwestern Uganda, May 2018
Authors: Musewa Angella , Mirembe Bernadette Basuta , Monje Fred , Birungi Doreen , Nanziri Carol , Aceng Freda Loy , Kabwama Steven N. , Kwesiga Benon , Ndumu Deo Birungi , Nyakarahuka Luke , Buule Joshua , Cossaboom Caitlin M. , Lowe David , Kolton Cari B. , Marston Chung K. , Stoddard Robyn A. , Hoffmaster Alex R. , Ario Alex Riolexus , Zhu Bao-Ping 
Published: August 2022

Abstract
Background
Anthrax is a zoonotic infection caused by the bacteria Bacillus anthracis. Humans acquire cutaneous infection through contact with infected animals or animal products. On May 6, 2018, three cows suddenly died on a farm in Kiruhura District. Shortly afterwards, a sub-county chief in Kiruhura District received reports of humans with suspected cutaneous anthrax in the same district. The patients had reportedly participated in the butchery and consumption of meat from the dead cows. We investigated to determine the magnitude of the outbreak, identify exposures associated with illness, and suggest evidence-based control measures.

Methods
We conducted a retrospective cohort study among persons whose households received any of the cow meat. We defined a suspected human cutaneous anthrax case as new skin lesions (e.g., papule, vesicle, or eschar) in a resident of Kiruhura District from 1 to 26 May 2018. A confirmed case was a suspected case with a lesion testing positive for B. anthracis by polymerase chain reaction (PCR). We identified cases through medical record review at Engari Health Centre and active case finding in the community.

Results
Of the 95 persons in the cohort, 22 were case-patients (2 confirmed and 20 suspected, 0 fatal cases) and 73 were non-case household members. The epidemic curve indicated multiple point-source exposures starting on May 6, when the dead cows were butchered. Among households receiving cow meat, participating in slaughtering (RR = 5.3, 95% CI 3.2–8.3), skinning (RR = 4.7, 95% CI = 3.1–7.0), cleaning waste (RR = 4.5, 95% CI = 3.1–6.6), and carrying meat (RR = 3.9, 95% CI = 2.2–7.1) increased the risk of infection.

Conclusions
This cutaneous anthrax outbreak was caused by handling infected animal carcasses. We suggested to the Ministry of Agriculture, Animal Industry and Fisheries to strengthen surveillance for possible veterinary anthrax and ensure that communities do not consume carcasses of livestock that died suddenly. We also suggested that the Ministry of Health equip health facilities with first-line antibiotics for community members during outbreaks.
Mathematical surface function-based design and 3D printing of airway stents
Authors: Yilmaz Bengi , Kara Bilge Yilmaz 
Published: August 2022

Abstract
Background
Three-dimensional (3D) printing is a method applied to build a 3D object of any shape from a digital model, and it provides crucial advantages especially for transferring patient-specific designs to clinical settings. The main purpose of this study is to introduce the newly designed complex airway stent models that are created through mathematical functions and manufactured with 3D printing for implementation in real life.

Methods
A mathematical modeling software (MathMod) was used to design five different airway stents. The highly porous structures with designated scales were fabricated by utilizing a stereolithography-based 3D printing technology. The fine details in the microstructure of 3D printed parts were observed by a scanning electron microscope (SEM). The mechanical properties of airway stents with various designs and porosity were compared by compression test.

Results
The outputs of the mathematical modeling software were successfully converted into 3D printable files and airway stents with a porosity of more than 85% were 3D printed. SEM images revealed the layered topography of high-resolution 3D printed parts. Compression tests have shown that the mathematical function-based design offers the opportunity to adjust the mechanical strength of airway stents without changing the material or manufacturing method.

Conclusions
A novel approach, which includes mathematical function-based design and 3D printing technology, is proposed in this study for the fabrication of airway stents as a promising tool for future treatments of central airway pathologies.