bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Research in the Malaysian Mining Industry and Its Contribution to Others Sectors: a Systematic Literature Review Approach
Authors: ISMAIL SITI NORAISHAH , SOFIAN AZIZUL HELMI 
Published: May 2022

Abstract
Malaysia is endowed with an abundance of diverse minerals, making the mining sector one of the country's most important industries. However, there is a scarcity of literature devoted to studies of the Malaysian mining sector. Thus, the objective of this systematic research was to (1) to investigate the research trends in the Malaysian mining industries. and (2) to study the contribution of mining industry with others sectors in Malaysia. A systematic literature review (SLR) using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) review technique discovered 24 papers linked to current research in the mining sector in Malaysia from 2016 to 2021 from the ScienceDirect and Scopus databases. Using thematic analysis, one primary theme and seven subthemes were produced based on 24 selected articles. The study on tin mining was the most widely circulated article in the preceding six years. Moreover, the research and publication on contribution of mining industry to various industries also were lacking such as in composite, cosmetic, construction industry and many more. In conclusion, the systematic review study may encourage mine owners, mine employees, government officials, and policymakers to write their own research and development (R&D), issues, or related problems in mining activities and publish them in reputable journals, conferences, and other publishing databases that will benefit the Malaysian mining industry.
Financial viability of a community-based health insurance scheme in two districts of northeast Ethiopia: a mixed methods study
Authors: Hussien Mohammed , Azage Muluken , Bayou Negalign Berhanu 
Published: May 2022

Abstract
Background: Community-based health insurance initiatives in low- and middle-income countries encountered a number of sustainability challenges due to their voluntary nature, small risk pools, and low revenue. In Ethiopia, the schemes’ financial viability has not been well investigated so far. This study examined the scheme's financial viability and explored underlying challenges from the perspectives of various key stakeholders. Methods: This study employed a mixed methods case study in two districts of northeast Ethiopia. By reviewing financial reports of health insurance schemes, quantitative data were collected over the last seven years to examine trends in financial status. Interviews were conducted face-to-face with nine community members and 19 key stakeholders. We used the maximum variation technique to select the study participants. Interviews were audio recorded, transcribed verbatim, and translated into English. Thematic analysis was applied with both inductive and deductive coding methods.Results: Both schemes experienced excess claims costs and negative net income in almost all the study period. Even after government subsidies, the scheme’s net income remained negative for some reporting periods. The challenges contributing to the observed level of performance have been summarized under five main themes, which include adverse selection, moral hazard behaviors, stockout of medicines, delays in claims settlement for service providers, and low insurance premiums. Conclusions: The health insurance scheme in both districts spent more than it received for claims settlement in almost all the period under the study, and experienced heavy losses in these periods, implying that it is not financially viable for the period in question. The scheme is also unable to fulfill its purpose of protecting members against out-of-pocket expenses at the point of health care. Interventions should target on the highlighted challenges to restore financial balance and enhance the scheme’s viability.
Statistical Data Integration for the Analysis of the Ecological Transition and Sustainable Development
Authors: Perchinunno Paola , Rotondo Francesco , Mongelli Lucia , L'Abbate Samuela 
Published: May 2022

Abstract
The evolution of the concept of sustainability and the availability of new statistical information requires constant checks on the set of indicators so that they accurately perform the task of representing well-being in our society. Statistics and regional sciences are called upon to contribute to the achievement of sustainability objectives by making available increasingly efficient and goal-oriented data, indicators, and methodologies of territorial analysis, to accompany every planning and implementation activity of sustainable development. The Sustainable Development Goals refer to various development domains relating to environmental, social, economic, and institutional issues that have been placed at the basis of the Missions envisaged by the National Recovery and Resilience Plan (NRRP). Specifically, the subject of ecological transition and the related statistical indicators and the evaluations of the effectiveness of the programming implemented by the NRRP to pursue it in practice are of significant interest. The numerous data available were analyzed at a regional level through multivariate statistical methodologies (Totally Fuzzy and Relative method) capable of synthesizing the various information to evaluate the territorial adequacy of the economic planning of its various components (MC1, MC2, MC3, MC4). Through the representation on a GIS basis of the geographical distribution of the synthesis values of the fuzzy indices, the need is shown to orient the economic planning of the NRRP missions in its main components in a more appropriate way to the different starting status of the Italian regions than for heterogeneous physical, historical, and economic characteristics require different development policies and therefore distinct economic resources for each component of the missions analyzed. Starting from the availability of multiple data updated to 2019, it is possible to develop an integrated approach to the evaluation of the local government policies in place and to monitor the progress of subsequent interventions by the Italian government.
Results of the treatment of pineal tumors in children: The Lyon experience
Authors: Szathmari Alexandru , Beuriat Pierre-Aurélien , Vasiljevic Alexandre , Leblond Pierre , Faure-Conter Cécile , Claude Line , Rocco Federico Di , mottolese carmine 
Published: May 2022

Abstract
Pineal tumors are rare and their incidence is of 1% among all pediatric tumors of the central nervous system. The survival depends on the histology, the extension of the surgical removal, the efficacy of the complementary treatment (chemotherapy and cranio-spinal irradiation) in relation with the age of the children.We report our experience in Lyon concerning 151 patients treated from 1997 to 2021. All patients were recorded in the French Register of Pineal tumors which is centralized in Lyon since 2010.The analysis shows that benign tumors have a good survival rate and a total surgical removal is manadatory. Concerning true pineal tumors, pinealoblastomas have a bad prognostic especially in children aged inferior to three years old. The new pathological classification allows a better stratification with different groups identified and also the identification of a DICER 1 syndrome in family of patients with a pinealoblastoma that need medical investigations. Results of Germ Cell Tumors are more favorable with a global survival rate of 87 % and a rate of survival for pure germinomas of almost 97%. Results for gliomas of the pineal gland, that are tectal plate gliomas, are good for pilocytic astrocytomas while for other gliomas the prognosis is related to the grade of malignancy and the efficacy of complementary treatment. Papillary tumors need a complete removal for the best chance of survival. Finally, AT/TR still have a bad prognosis.Our results show that many progresses have to be accomplished for pineal region tumors and that these pathologies need a multidisciplinary approach to choose the best treatment to improve the survival rate and the patients’ quality of life.
Marginal Adaptation of Ormocer, Nanofilled, and Nanoceramic Class V Composite Restorations Subjected to Thermal and load Cycling
Authors: Mahmoud Salah Hasab , Eltoukhy Radwa , Elkaffas Aly Atef , Salama Rasha 
Published: May 2022

Abstract
Background: The marginal integrity of resin composite restorations especially in class V cavities remains a challenge in operative dentistry. This study aimed to evaluate the effect of substrate and restorative system on the marginal adaptation of class V composite restorations. Methods: Standardized class V cavities were prepared in sound human molars with the cervical margin on dentin and the occlusal margin on enamel. An ormocer, nanofilled, nanoceramic and microhybrid composite were utilized. After finishing and polishing, marginal adaptation of the restorations was analyzed by metallographic microscope (T0) and the following parameters were recorded: width of maximum marginal gap (MG), percentage length of debonded margin relative to cavity periphery (DM), and marginal index (MI = MG × DM/100). After the first evaluation, the specimens underwent thermal cycling (2,000 cycles of 5ºC–55ºC ± 2ºC) and load cycling (50,000 cycles of 50 N and 1 Hz). Specimens were reanalyzed by metallographic microscope (T1). The recorded data were compared using multi-way analysis of variance (ANOVA) and Tukey’s test (ɑ < 0.05). Results: The type of restorative/adhesive system and margin location significantly affected marginal adaptation. Ormocer restorations exhibited the lowest MG, DM, and MI values, whereas microhybrid composite restorations exhibited the highest values. Relative to the baseline condition, the specimens showed higher gap measurements after thermal and load cycling. Conclusion: The margin location and restorative system have a substantial effect on the marginal adaptation of class V composite restorations. Clinical relevance statement:The cavity margin location and the restorative system have significant influence on the durability of cervical restorations.
Understanding multimode orientation-dependent oxidation of aluminum by first-principles theory calculations
Authors: Pu Jibin , Liu Min , Wang Yongxin , Jin Ying , Pan Jinshan 
Published: May 2022

Abstract
The behavior of oxygen (O) atoms on the surface as well as the subsurface of (111), (001), and (110) orientations of aluminum (Al) during initial-stage oxidation is studied by using density-functional theory (DFT), focusing on adsorption energy, work function, surface relaxation/reconstruction, surface complex formation with evolving structural parameters with increasing coverage of adsorbing O up to two-monolayer. The energetics of O adsorption indicate a favorable oxidation behavior with a large work function increase induced by O on Al(111) and (110). The structural as well as electron re-distribution analyses reveal that spontaneous O ingress into (110) leads to an “intercalating” oxidation mode, which may also result in a much faster surface oxidation process, whereas the oxidation on Al(111) and (001) proceeds similarly in a “layer-by-layer” mode with a slower oxidation rate. Moreover, different complexes of Al-O are formed depending on the availability of O towards Al on different orientations. The evolution of Al-O bond length suggests that the formed oxide resembles α-Al2O3 on (111)/(001) and γ-Al2O3 on (110), respectively. These results have differentiated different oxidation modes as well as kinetics predominantly dependent on surface orientations.
Comparative Study of Some Iterative Methods For Solving Poisson Equations
Authors: Derzie Eshetu Belete , Dinka Tekle Gemechu 
Published: May 2022

Abstract
Objectives: This study focuses on some iterative algorithms (Jacobi, Gauss-Seidel, SOR, and Multigrid) for solving Poisson's equations and investigating their performance based on the computational time complexity point of view. These iterative methods are derived to solve linear systems resulting from the discretization of Poisson's equations using finite difference methods.Results: For each method, the rate of convergence is analyzed. Our analysis shows that the Multigrid method is efficient among the other methods to solve Poisson's equations. Numerical experiments are carried out to validate the theoretical results.AMS Subject Classification: Primary 65F10; 65N06; secondary 65N55
Reflective texture-less object registration using multiple edge features for augmented reality assembly
Authors: He Zaixing , Zhao Jindong , Zhao Xinyue , Feng Wuxi , Wang Quanyou , Jiang Huilong 
Published: May 2022

Abstract
Virtual assembly technology has developed rapidly in recent years. As one of its key technologies, object registration has been widely studied, whose main task is to register the target object. However, the existing methods cannot effectively register reflective texture-less objects such as metal parts. In this paper, an object registration method based on multiple edge features is proposed, which includes a sparse uniform template sampling method and a multiple edge feature matching method. At the same time, we also used two oil pumps to carry out virtual assembly experiments and verify the accuracy of object registration. The experimental results show that this method can achieve high accuracy which is in line with the requirements of the virtual assembly algorithm in the industry.
Copper-Based Metal-Organic Framework Impedes Triple-Negative Breast Cancer Metastasis via Local Estrogen Deprivation and Platelets Blockade
Authors: Wang Sijie , Yin Na , Li Yongjuan , Xiang Tingting , Jiang Wenxiao , Zhao Xiu , Liu Wei , Zhang Zhenzhong , Shi Jinjin , Guo Xingming , Zhang Kaixiang , Liu Junjie 
Published: May 2022

Abstract
Metastasis is one of the main causes of failure in the treatment of triple-negative breast cancer (TNBC). Abnormally estrogen level and activated platelets are the key driving forces for TNBC metastasis. Here, an “ion/gas” bioactive nanogenerator (termed as IGBN), comprising a copper-based MOF and loaded cisplatin-arginine (Pt-Arg) prodrug, is developed for metastasis-promoting tumor microenvironment reprogramming and TNBC therapy. The copper-based MOF not only serves as a drug carrier, but also specifically produces Cu2+ in tumors, which catalytic oxidizing estrogen to reduce estrogen levels in situ. Meanwhile, the rationally designed Pt-Arg prodrug reduced into cisplatin to significantly promote the generation of H2O2 in the tumor, then permitting self-augmented cascade NO gas generation by oxidizing Arg through a H2O2 self-supplied way, thus blocking platelet activation in tumor. We clarified that IGBN inhibited TNBC metastasis through local estrogen deprivation and platelets blockade, affording 88.4% inhibition of pulmonary metastasis in a 4T1 mammary adenocarcinoma model. Notably, the locally copper ion interference, NO gas therapy and cisplatin chemotherapy together resulted in an enhanced therapeutic efficacy in primary tumor ablation without significant toxicity. This “ion/gas” bioactive nanogenerator offers a robust and safe strategy for TNBC therapy.
Short-term Exposure to JUUL Electronic Cigarettes Can Worsen Ischemic Stroke Outcome by Disrupting the Blood-Brain Barrier
Authors: Sifat Ali Ehsan , Archie Sabrina Rahman , Nozohouri Saeideh , Villalba Heidi , Ghanwatkar Yashwardhan , Sharma Sejal , Zhang Yong , Vaidya Bhuvaneshwar , Cucullo Luca , Abbruscato Thomas J. 
Published: May 2022

Abstract
Background
The short and long-term health effects of JUUL electronic cigarette (e-Cig) are largely unknown and warrant extensive research. We hypothesized that chronic exposure to JUUL vapor could promote cerebrovascular toxicities impacting the progression and outcome of ischemic stroke to an extent comparable to that resulting from tobacco smoke (TS) exposure.
Methods
We exposed male C57 mice to TS/ JUUL vapor for 14 days. LCMS/MS was used to measure brain and plasma nicotine and cotinine level. Transient middle cerebral artery occlusion (tMCAO) followed by reperfusion was used to mimic ischemic stroke. Plasma levels of IL-6 and thrombomodulin were assessed by enzyme-linked immunosorbent assay. At the same time, western blotting was used to study blood-brain barrier (BBB) tight junction (TJ) proteins expression and that of key inflammatory and oxidative stress markers.
Results
tMCAO upregulated IL-6 and decreased plasma thrombomodulin levels. Post-ischemic brain injury following tMCAO was significantly worsened by JUUL/TS pre-exposure. TJ proteins expression was also downregulated by JUUL/TS pre-exposure after tMCAO. Similar to TS, exposure to JUUL downregulated the expression of the antioxidant Nrf2. The inflammatory marker ICAM-1 was also significantly upregulated by TS pre-exposure following tMCAO and by JUUL but to a lesser extent.
Conclusions
Our results suggest that JUUL exposure could negatively impact the cerebrovascular system as much as TS exposure.
Accurate detection of cholesterol in the presence of phytosterols in food samples based on lead halide perovskites with aggregation-induced emission
Authors: Jiao Aiqing , Ge Wenna , Jiang Dafeng , Qu Fei , Zhao Xian-En 
Published: May 2022

Abstract
A kind of lead halide perovskites (LHPs) with aggregation-induced emission (AIE) feature is used as a fluorescent probe for cholesterol detection. LHPs exhibit a high emission when they aggregate in water. However, β-cyclodextrin modified gold nanoparticles (β-CD@AuNPs) cause the AIE quenching of LHPs. Based on the host-guest recognition between β-cyclodextrin (β-CD) and cholesterol, LHPs are replaced by cholesterol, resulting in the AIE recovery of LHPs. A linear range of cholesterol is obtained from 0.35 to 20 nM with the limit of detection 0.12 nM which is lower than the most reported methods. This is because only a few pM β-CD@AuNPs quench the AIE of LHPs. Furthermore, phytosterols cannot interfere with the detection of cholesterol due to the different affinities of cholesterol and phytosterols for β-CD. Finally, this method is applied to detecting cholesterol in egg, milk, and pork. Additionally, cholesterol in milk powder containing phytosterols has been determined with good recoveries.
Tanshinone IIA reduces AQP4 expression and astrocyte swelling after oxygen-glucose deprivation and reoxygenation by inhibition of the HMGB1/RAGE/NF-κB/IL-6 pro-inflammatory axis
Authors: Tang Zhaohua , Yang Gang , Liao Zhengbu , Chen Feilan , Chen Song , Tao Wangwen , Huo Gang , Sun Xiaochuan , Wang Xiaoshu 
Published: May 2022

Abstract
Here, we investigated the role of tanshinone IIA (TSO IIA) in astrocytic swelling caused by ischemia and reperfusion-like injury in an in vitro model and the molecular mechanisms underlying this effect. Primary brain astrocytes were cultured in conditions of glucose and oxygen deprivation and reoxygenation (OGD/R). We investigated the effects of TSO IIA treatment on cell swelling and injury, and the expression levels of AQP4 protein in the plasma membrane. We then studied the involvement of the HMGB1/RAGE/NF-κB/IL-6 pro-inflammatory axis in TSO IIA-mediated protection. Treatment with TSO IIA alleviated OGD/R-induced astrocytic swelling and the over-clustering of AQP4 protein in the plasma membrane. In addition, TSO-IIA significantly reduced over-expression of HMGB1, the high levels of NF-κB protein in the nucleus, and of IL-6 protein in cytoplasm and extracellular media induced by OGD/R. Combination of TSO IIA and recombinant HMGB1 reversed these effects. Inhibition of RAGE, the receptor of HMGB1, induced similar results to those of TSO IIA. In addition, exogenous IL-6 reversed TSO IIA-mediated effect on AQP4 over-clustering and cell swelling.TSO IIA significantly reduced astrocyte swelling after OGD/R injury in vitro, via blocking activation of the HMGB1/RAGE/NF-κB/IL-6 pro-inflammatory axis and thereby decreasing the expression of AQP4 in plasma membrane.
Maladaptive personality traits as predictors of prosocial behavior and behavioral trust in two economic games
Authors: Hepp Johanna , Mohr Melissa R. M. , Niedtfeld Inga 
Published: May 2022

Abstract
Background: Dimensional models of personality disorders postulate interpersonal dysfunction as the core feature of personality pathology, and describe maladaptive personality traits that characterize the specific pattern of dysfunction that is experienced. Herein, we examined whether maladaptive traits predict prosocial behavior and behavioral trust, both of which are highly relevant behaviors for interpersonal functioning. Specifically, we examined antagonism as a predictor of prosocial behavior in a dictator game, and suspiciousness as a predictor of trust in the faith game. Materials and Methods: The study was preregistered and conducted online. The preregistration protocol is available at https://osf.io/er43j. Data and code are available at https://osf.io/2rvbg/. Participants (N = 445) completed the German version of the Personality Inventory for DSM-5 to measure antagonism and suspiciousness. Additionally, they played the dictator game (more money taken away from another person indicates less prosocial behavior) and the faith game (choosing the sure choice instead of the faith choice indicates less trust). We conducted a linear regression model to test whether antagonism is associated with prosocial behavior in the dictator game and a logistic regression model to test whether suspiciousness predicts selection of the sure choice in the faith game.Results: As hypothesized, higher levels of antagonism were associated with less prosocial behavior in the dictator game. The remaining hypotheses were not supported, as suspiciousness was not significantly associated with the likelihood of choosing the sure choice in the faith game. Exploratory analyses on participants’ estimates of the sure choice amount suggest successful experimental manipulation in the faith game. Conclusions: The results on antagonism and prosocial behavior are consistent with those of previous studies that used categorial classification systems of personality disorders or examined non-pathological personality traits. Potential explanations for the non-significant effects of suspiciousness are discussed, including the small size and range of the sure choice payoff and that the anonymity of the game may have precluded suspicious traits from expressing. Future research with higher stakes and known interaction partners is needed to further probe the effects of suspiciousness.
Occupational Exposure to High-level Electric Fields and Mechanistic Effects of External Supplements
Authors: Tomruk Arın , Buyukatalay Elcin Ozgur , Kaya Ufuk , Ulusu N. Nuray , Ozturk Goknur Guler 
Published: May 2022

Abstract
The rate of workplace-related various diseases will have arisen. Electrical workers, particularly, might be exposed to different physical, chemical, and biological agents. The respiratory system will be more vulnerable to the initiated inflammatory responses with the combined effects of these dangerous agents. The present study investigated E field-induced intracellular reactive intermediates' status and their disruptive impacts on structural molecules. Moreover, the lung tissues' antioxidant levels and preventive effects of external treated NAC and EGCG were also investigated under long-term E field exposure. The long-term exposure to 50 Hz 24kV/m vertical E Field might indirectly affect the guinea pigs' lung tissues overproducing intracellular ROS. Oxygen and nitrogen-derived reactive intermediates primarily injured lipids' and proteins' structures. With the treatments of NAC and EGCG, this disruptive effect decreased under E field exposure. In establishing safety limits for occupational exposures of electrical workers (more than 10kV/m), there is a need for further mechanistic studies on the relationships between high-level electric fields' exposures and occupational-related diseases at the molecular level.