bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge on Coronavirus Disease (COVID-19) and Practice of COVID-19 Prevention Among Students in the Health Campus
Authors: Canti Nurul Atikah Nuraini , Mohd Zain Norhasmah , Embong Hasni 
Published: August 2022

Introduction: Knowledge of COVID-19 and the practices towards the prevention of COVID-19 are crucial especially among health sciences students who are required to do a clinical placement at a hospital. This study aimed to assess the knowledge on COVID-19 and practice of COVID-19 prevention among university students.
Methods: A cross-sectional study was conducted via a web-based survey. A total of 273 students of the medical, dental and health sciences programs were invited to participate in this study using stratified random sampling methods. A set of questionnaires developed by WHO training material for identification, prevention, response, and control of COVID-19 was used.
Results: Most of the respondents were fourth year students (37.4%) age of 22 years old. The mean of total knowledge score was 23.14 ± 1.50. The overall mean score for the practice towards prevention of COVID-19 was 30.06 ± 3.03. The findings revealed that 71.1% students had good knowledge while 28.9% of them had poor knowledge regarding COVID-19. Half (58.6%) of the students have good practice and 41.4% had poor practice of COVID-19 prevention. There is no significant correlation of knowledge on COVID-19 and the practice of COVID-19 prevention.
Conclusion: This study emphasizes the need for continuous education and a regular reminder to the student population involved in the clinical area regarding infectious disease prevention.
Total en bloc spondylectomy for the L5 metastasis of a carcinoid tumor: illustrative case
Authors: Jódar Cristina P. , Fuentes Caparrós Simón , Marín Miguel A. , Osuna Soto Julio 
Published: August 2022

BACKGROUND
Total en bloc spondylectomy (TES) was designed to achieve oncological complete tumor resection in a vertebral compartment. Because of the special anatomy of the lumbosacral junction, TES procedure at the L5 level is a challenge, and it has been explained in few reports in the literature. Performing TES in the lower lumbar region, as normal, is accomplished by using a combined approach.

OBSERVATIONS
The authors presented the case of a 20-year-old man with an isolated spinal metastasis at the L5 level of carcinoid tumor of jejunum, limited to the vertebral body. Due to good long-term prognosis, after multidisciplinary evaluation the authors decided to treat the patient with TES through a combined posteroanterior approach, with posterior instrumentation and anterior reconstruction. Nine years after surgery, the patient was asymptomatic, with no sign of local recurrence.

LESSONS
TES is a feasible technique to provide long-term survival in a select subgroup of patients, reducing the risk of local recurrence. The authors presented some anatomical and biomechanical factors that must be considered at the lumbosacral region. Despite the high rates of complication associated with TES, most patients benefit from local control provided by the technique.
Sistem Pendukung Keputusan Penilaian Kinerja Helpdesk Data Management Di PT. Telkom Witel Bandung Menggunakan Metode TOPSIS
Authors: Saputra Prasetya Adhytiatama , Gunawan Hendra 
Published: August 2022

PT. Telkom adalah salah satu perusahaan yang memanfaatkan teknologi informasi dan internet secara bersamaan dengan sangat baik, bahkan perusahaan ini merupakan perusahaan terbesar yang bergerak di bidang telekomunikasi. Dalam menjalankan proses bisnisnya, PT. Telkom memanfaatkan teknologi informasi yang ada pada saat ini. Teknologi informasi yang dimanfaatkan nya antara lain; website dan internet. Akan tetapi, dalam kegiatan penilaian untuk karyawan masih belum menggunakan teknologi informasi apapun. Oleh karena itu, penulis mengambil tema penelitian berjudul “Sistem Pendukung Keputusan Penilaian Kinerja Helpdesk Data Management Di PT. Telkom Witel Bandung Menggunakan Metode TOPSIS”.TOPSIS adalah salah satu metode pengambilan keputusan multi kriteria yang pertama kali diperkenalkan oleh Yoon dan Hwang pada tahun 1981. TOPSIS menggunakan prinsip bahwa alternatif yang terpilih harus mempunyai jarak terdekat dari solusi ideal positif dan jarak terpanjang (terjauh) dari solusi ideal negatif dari sudut pandang geometris dengan menggunakan jarak Euclidean (jarak antara dua titik) untuk menentukan kedekatan relatif dari suatu alternatif.Hasil dari penulisan yang dilakukan oleh penulis menghasilkan sebuah sistem pendukung keputusan yang nantinya akan membantu pihak perusahaan dalam menentukan karyawan terbaik pada divisi helpdesk data management.
Pengaruh Tax Avoidance Terhadap Cost Of Debt Dan Dampaknya Terhadap Nilai Perusahaan (Studi Empiris Pada Perusahaan Manufaktur Yang Terdaftar Di Bursa Efek Indonesia Tahun 2015-2017)
Authors: Saparinda Raden Wulan 
Published: August 2022

The purpose of this research is to analyze tax avoidance on the cost of debt and it affects the firm value. This research uses a sample of manufacturing companies on the Indonesia Stock Exchange for the period 20152017. The program used in analyzing data uses SPSS 21 . This research found that tax avoidance has a positive influence on the cost of debt t test showing significance of 0.003 <0.05. Cost of Debt has a negative effect on firm value with a significance of 0,000 <0,05. Tax avoidance does not affect on firm value because of the significance of 0.052> 0.05. The cost of debt can mediate the effect of tax avoidance on firm value with a significance of 0.025 <0.05. The path analysis results is a direct effect of X on Y by 9,1%, direct effect of Y on Z by 15,84% and there is an indirect effect of X on Z through Y by -12%.
Sistem Informasi UKM Futsal STMIK IKMI Cirebon Berbasis WEB Menggunakan Metode Waterfall
Authors: Baihaqi Achmad , Suarna Nana , Amalia Rizki Dita 
Published: August 2022

Information about an Organination or a Student Activity Unit is very important to inform the activities carried out by an organization or Student Activity Unit, such as the Futsal STMIK IKMI Cirebon Student Activity Unit. The process of managing the administration of members who are still manual, providing information that has not been and the absence of archives of the activities that have been carried out make the Futsal Student Activity Unit at STMIK IKMI Cirebon unable to recap activities. This is a factor in the futsal student activity unit's problems in member data and activity archives. This research will create a system that can accommodate existing problems. This research uses the waterfall method to develop the system. The system created will later use the website as a medium. This research method was chosen because it is a simple process and also easy to apply. The stages in this waterfall method include Needs Analysis, System Design, Workmanship, Verification, and Maintenance. The system created will improve student services and make it easier for futsal student activity unit administrators to convey information and make it easier for members to obtain information.
BAC cloning and heterologous expression of a giant biosynthetic gene cluster encoding antifungal neotetrafibricin in streptomyces rubrisoli
Authors: Park Heung-Soon , Park Ji-Hee , Kim Hye-Jin , Kang Seung-Hoon , Choi Si-Sun , Kim Eung-Soo 
Published: August 2022

Polyene natural products including nystatin A1, amphotericin B, ECO-02301, and mediomycin belong to a large family of valuable antifungal polyketide compounds typically produced by soil actinomycetes. A previous study (Park et al., Front. Bioeng. Biotechnol., 2021, 9, 692340) isolated Streptomyces rubrisoli Inha501 with strong antifungal activity and analyzed a large-sized biosynthetic gene cluster (BGC) of a linear polyene compound named Inha-neotetrafibricin (I-NTF) using whole genome sequencing and bioinformatics. In the present study, an entire I-NTF BGC (∼167 kb) was isolated through construction and screening of Streptomyces BAC library. Overexpression of the cloned I-NTF BGC in the wild-type S. rubrisoli Inha501 and its heterologous expression in S. lividans led to 2.6-fold and 2.8-fold increase in I-NTF yields, respectively. The qRT-PCR confirmed that the transcription levels of I-NTF BGC were significantly increased in both homologous and heterologous hosts containing the BAC integration of I-NTF BGC. In addition, the I-NTF aglycone-producing strains were constructed by a target-specific deletion of glycosyltransferase gene present in I-NTF BGC. A comparison of the in vitro biological activities of I-NTF and I-NTF aglycone confirmed that the rhamnose sugar motif of I-NTF plays a critical role in both antifungal and antibacterial activities. These results suggest that the Streptomyces BAC cloning of a large-sized natural product BGC is a valuable approach for natural product titer improvement and biological activity screening of natural product in actinomycetes.
Potential value of pre- and post-therapy [68Ga]Ga-DOTA-TATE PET/CT in the prognosis of response to PRRT in disseminated neuroendocrine tumors
Authors: Opalińska Marta , Morawiec-Sławek Karolina , Kania-Kuc Adrian , Al Maraih Ibraheem , Sowa-Staszczak Anna , Hubalewska-Dydejczyk Alicja 
Published: August 2022

BackgroundPeptide receptor radionuclide therapy (PRRT) is one of the most effective therapeutic options for the treatment of metastatic, well-differentiated neuroendocrine tumors (NETs). It improves progressive disease-free survival and enables the control of hormone secretion in functioning tumors.Currently, there are no clearly established predictors of response to PRRT. The main factors hindering such a prediction are the heterogeneity of somatostatin receptor expression within and between lesions, lack of standardized parameters for functional imaging, and the use of different PRRT protocols.The main goal of our study was to quantify SUVmax changes in [68Ga]Ga-DOTA-TATE PET/CT scans as a potential predictor of long-term response to PRRT.Material and methodsOut of 20 patients treated with PRRT using [177Lu]Lu and/or [177Lu]Lu/[90Y]Y-DOTA-TATE in 2017–2019 due to dissemination of neuroendocrine neoplasm, 12 patients underwent [68Ga]Ga-DOTA-TATE PET/CT on average 3.1 months before and 4.5 months after PRRT and were eligible for the analysis.In total, 76 NET lesions were evaluated. We measured SUVmax for every lesion in both PET/CT scans (before and after PRRT). Those values were corrected by liver SUVmax and liver SUVmean measured in volumetric analysis and specified as SUVlmax and SUVlmean. As a next step, changes in SUVlmax and SUVlmean were assessed based on both PET/CT scans. Finally, results were correlated with the clinical outcome assessed as progressive disease, disease stabilization, or partial response.ResultsThe mean follow-up period was 19.9 months. Progressive disease, partial response, and disease stabilization were found in five, two, and five patients, respectively. Among patients with a partial response, the decrease in mean SUVlmax was 66.3% when compared to baseline. In patients with stable disease, the decrease in SUVlmax was 30.3% when compared to baseline. In patients with progressive disease, the mean increase in SUVlmax was 9.1% when compared to baseline. The changes in SUVlmean were -69,8%, -30.8%, and -3.7%, respectively.ConclusionsA decrease in the SUVmax value in NET lesions, corrected by normal liver tissue uptake assessed in [68Ga]Ga-DOTA-TATE PET/CT scans, indicates a lower risk for NET progressive disease within 20 months after PRRT and may constitute an additional and independent parameter for the estimation of overall risk for disease progression.
Lutein nanodisks protect human retinal pigment epithelial cells from UV light-induced damage
Authors: Moschetti Anthony , Fox Colin A. , McGowen Samuel , Ryan Robert O. 
Published: August 2022

The hydrophobic carotenoid, lutein, was conferred with aqueous solubility upon formulation into reconstituted discoidal high density lipoprotein particles, termed lutein nanodisks (ND). When formulated with phosphatidylcholine (PC), apolipoprotein (apo) A-I and lutein (formulation ratio = 5 mg PC/2 mg apoA-I/1 mg lutein), lutein solubilization efficiency in phosphate buffered saline (PBS) was ∼90%. The UV/Vis absorbance maxima for lutein ND in PBS were red shifted by 6–13 nm versus the corresponding lutein absorbance maxima in ethanol. FPLC gel filtration chromatography gave rise to a single major absorbance peak in the size range of ND. Incubation of cultured ARPE-19 cells with lutein ND resulted in lutein uptake, as determined by HPLC analysis of cell extracts. Compared to control incubations, ARPE-19 cells incubated with lutein ND were protected from UV light-induced loss of cell viability. Consistent with this, reactive oxygen species generation, induced by exposure to UV irradiation, was lower in lutein-enriched cells than in control cells. Thus, uptake of ND-associated lutein protects ARPE-19 cells from UV light-induced damage. Taken together, the data indicate ND provide an aqueous lutein delivery vehicle for biotechnological or therapeutic applications.
Anemia tolerance versus blood transfusion on long-term outcomes after colorectal cancer surgery: A retrospective propensity-score-matched analysis
Authors: Weng Meilin , Guo Miaomiao , Li Ting , Zhou Changming , Sun Caihong , Yue Ying , Liao Qingwu , Cai Sanjun , Lu Xihua , Zhou Di , Miao Changhong 
Published: August 2022

BackgroundPerioperative anemia and transfusion are intertwined with each other, and both have adverse impacts on the survival of colorectal cancer (CRC) patients. But the treatment of anemia still relies on transfusion in several countries, which leads us to question the effects of anemia tolerance and transfusion on the long-term outcomes of CRC patients. We investigated the combined effect of preoperative anemia and postoperative anemia and of preoperative anemia and blood transfusion, which imposes a greater risk to survival, to compare the effects of anemia tolerance and transfusion on overall survival (OS) and disease-free survival (DFS) in patients undergoing CRC surgery.MethodsA retrospective propensity-score-matched analysis included patients with CRC undergoing elective surgery between January 1, 2008, and December 31, 2014. After propensity-score matching, Kaplan–Meier survival analysis and univariable and multivariable Cox proportional hazards models were used to study the prognostic factors for survivals. In univariate and multivariate Cox regression analysis, two novel models were built.ResultsOf the 8,121 patients with CRC, 1,975 (24.3%) and 6,146 (75.7%) patients presented with and without preoperative anemia, respectively. After matching, 1,690 patients remained in each group. In the preoperative anemia and postoperative anemia model, preoperative anemia and postoperative anemia was independent risk factor for OS (HR, 1.202; 95% CI, 1.043–1.385; P=0.011) and DFS (HR, 1.210; 95% CI, 1.050–1.395; P=0.008). In the preoperative anemia and transfusion model, preoperative anemia and transfused was the most dangerous independent prognostic factor for OS (HR, 1.791; 95% CI, 1.339–2.397; P&lt;0.001) and DFS (HR, 1.857; 95% CI, 1.389–2.483; P&lt;0.001). In patients with preoperative anemia, the OS and DFS of patients with transfusion were worse than those of patients without transfusion (P=0.026 in OS; P=0.037 in DFS).ConclusionsPreoperative anemia and blood transfusion imposed a greater risk to OS and DFS in patients undergoing CRC surgery, indicating that the harm associated with blood transfusion was greater than that associated with postoperative anemia. These findings should encourage clinicians to be vigilant for the timely prevention and treatment of anemia, by appropriately promoting toleration of anemia and restricting the use of blood transfusion in patients with CRC.
Intravenous branched-chain amino-acid-free solution for the treatment of metabolic decompensation episodes in Spanish pediatric patients with maple syrup urine disease
Authors: Sánchez-Pintos Paula , Meavilla Silvia , López-Ramos María Goretti , García-Cazorla Ángeles , Couce Maria L. 
Published: August 2022

BackgroundMetabolic decompensation episodes (DEs) in Maple Syrup urine disease (MSUD) result in brain accumulation of toxic branched-chain amino acids (BCAAs) and their respective branched-chain α-keto acids that could induce neuroinflammation, disturb brain bioenergetics, and alter glutamate and glutamine synthesis. These episodes require immediate intervention to prevent irreversible neurological damage. Intravenous (IV) administration of BCAA-free solution could represent a powerful alternative for emergency treatment of decompensations.MethodsThis pediatric series discusses the management of DEs in MSUD patients with IV BCAA-free solution, as an emergency treatment for DEs or as a prophylactic in cases requiring surgery. Clinical evolution, amino acid profile and adverse effects were evaluated.ResultsWe evaluated the use of BCAA-free solution in 5 DEs in 5 MSUD pediatric patients, all with significantly elevated plasma leucine levels at admission (699–3296 μmol/L) and in 1 episode of risk of DE due to surgery. Leucine normalization was achieved in all cases with resolution or improvement of clinical symptoms following IV BCAA-free solution. The duration of administration ranged from 3–20 days. Administration of IV BCAA-free solution at the beginning of a DE could reverse depletion of the amino acids that compete with BCAAs for the LAT1 transporter, and the observed depletion of alanine, despite IV alanine supplementation. No related adverse events were observed.ConclusionsAdministration of standardized IV BCAA-free solution in emergency settings constitutes an important and safe alternative for the treatment of DEs in MSUD, especially in pediatric patients for whom oral or enteral treatment is not viable.
Cold Water Immersion Improves the Recovery of Both Central and Peripheral Fatigue Following Simulated Soccer Match-Play
Authors: Bouchiba Mustapha , Bragazzi Nicola Luigi , Zarzissi Slim , Turki Mouna , Zghal Firas , Grati Mohamed Amine , Daab Wael , Ayadi Fatma , Rebai Haithem , Ibn Hadj Amor Hassen , Hureau Thomas J. , Bouzid Mohamed Amine 
Published: August 2022

The present study aimed to investigate the effect of cold water immersion (CWI) on the recovery of neuromuscular fatigue following simulated soccer match-play. In a randomized design, twelve soccer players completed a 90-min simulated soccer match followed by either CWI or thermoneutral water immersion (TWI, sham condition). Before and after match (immediately after CWI/TWI through 72 h recovery), neuromuscular and performance assessments were performed. Maximal voluntary contraction (MVC) and twitch responses, delivered through electrical femoral nerve stimulation, were used to assess peripheral fatigue (quadriceps resting twitch force, Qtw,pot) and central fatigue (voluntary activation, VA). Performance was assessed via squat jump (SJ), countermovement jump (CMJ), and 20 m sprint tests. Biomarkers of muscle damages (creatine kinase, CK; Lactate dehydrogenase, LDH) were also collected. Smaller reductions in CWI than TWI were found in MVC (-9.9 ± 3%vs-23.7 ± 14.7%), VA (-3.7 ± 4.9%vs-15.4 ± 5.6%) and Qtw,pot (-15.7 ± 5.9% vs. -24.8 ± 9.5%) following post-match intervention (p &lt; 0.05). On the other hand, smaller reductions in CWI than TWI were found only in Qtw,pot (-0.2 ± 7.7% vs. -8.8 ± 9.6%) at 72 h post-match. Afterwards, these parameters remained lower compared to baseline up to 48–72 h in TWI while they all recovered within 24 h in CWI. The 20 m sprint performance was less impaired in CWI than TWI (+11.1 ± 3.2% vs. +18 ± 3.6%, p &lt; 0.05) while SJ and CMJ were not affected by the recovery strategy. Plasma LDH, yet no CK, were less increased during recovery in CWI compared to TWI. This study showed that CWI reduced both central and peripheral components of fatigue, which in turn led to earlier full recovery of the neuromuscular function and performance indices. Therefore, CWI might be an interesting recovery strategy for soccer players.
Burnout and Psychological Wellbeing Among Psychotherapists: A Systematic Review
Authors: Van Hoy Angelika , Rzeszutek Marcin 
Published: August 2022

ObjectivesThe general aim of this systematic review is to synthesize, analyze, and critically review existing studies concerning the relationship between sociodemographic, intrapersonal, and work-related factors and burnout, as well as psychological wellbeing among psychotherapists.MethodologyWe performed a structured literature search utilizing the PRISMA framework in the following databases: Web of Science, Scopus, MedLine, PsyARTICLES, ProQuest, and Google Scholar. The most relevant inclusion criteria were quantitative and peer-reviewed articles published in English.ResultsAfter the selection process, we accepted 52 articles for further systematic review. Thirty-eight studies examined burnout among psychotherapists, while the other 14 studies focused on psychological wellbeing in this sample.ConclusionsBurnout and wellbeing among psychotherapists are related to numerous sociodemographic (e.g., age, gender), intrapersonal (e.g., coping, personality), and work-related characteristics, including work settings and professional support in this profession (e.g., supervision or personal therapy). However, the high heterogeneity observed between studies in terms of burnout and wellbeing operationalization and measurement warrants more consistent and advanced methodological models of these theoretical constructs in the future in this specific sample.