bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROTESTANTISM – REGULATION OF CONSUMPTION
Authors: Ermolaev Vladimir A. 
Published: November 2022

In the article, the author examines the gastronomic culture and its regulatory function, expressed in the regulation of eating behavior and food consumption by people through the existence of prohibitions and permits. In particular, it is indicated that such tools, as a rule, find their place in religious canons (codes of rules).
Speaking about the religious regulation of consumption, the author examines Protestantism and its currents and trends. According to the results of the study, it was revealed that within the framework of Adventism, Lutheranism, Anglicanism, Mormonism, Jehovah’s Witnesses, etc., there are tools for regulating food consumption that have a characteristic similarity with those in Judaism, Islam and Catholicism. Of course, Protestantism, being a denomination of Christianity, along with Catholicism, can borrow some rules and features. Meanwhile, drawing an analogy with these religions and confessions, we can talk about the existence of prohibited and permitted food, while in some areas of Protestantism restrictions are not as strict as in others.
Religion, acting as a regulator of eating behavior, designates products originating from “unclean” and “pure” animals and birds. At the same time, in the Bible, the signs that make it possible to differentiate food have a symbolic meaning – “unclean” food sources symbolize mundanity, the impossibility of turning to God, the sinfulness of man.
As a result, a gastronomic cultural layer is formed, within which the nutrition of believers, that is, the products they use daily, also taking into account national characteristics, not only have an impact on health, but also have a symbolic meaning of commitment to God, enlightenment, etc.
According to the results of the study, the author formulated the factors that are important in determining eating behavior and consumption: a) symbolizing; b) cleansing; c) providing and d) adapting (relevant to the current situation of globalization of the world space and the technologization of life spheres).
Evaluación histológica del daño renal producido por los inhibidores del punto de control inmunitario
Authors: Revuelta Sara , Tascón Javier , Vicente-Vicente Laura , Casanova Alfredo G. , Morales Ana I. , Prieto Marta 
Published: November 2022

Los inhibidores del punto de control inmunitario (ICI) constituyen el grupo inmunoterapéutico más relevante del ámbito oncológico, pero no están exentos de efectos adversos. Las lesiones renales, aunque raras, empeoran el pronóstico. Actualmente existen combinaciones de inmunoterapia y quimioterapia que mejoran la eficacia, pero aumentan el riesgo de sufrir efectos secundarios nefrotóxicos. El objetivo fue la evaluación histológica del daño renal asociado a los ICI anti-CTLA-4 y anti-PD-1 en combinación con cisplatino.
Se diseñó un modelo experimental en ratones C57BL/6 tratados con la terapia combinada de cisplatino (10 mg/kg, dosis única) con anti-CTLA-4 o anti-PD-1 (10 o 15 mg/kg/día, durante 6 días). Se incluyeron grupos con las monoterapias de los fármacos y un grupo control. La evaluación del daño renal histológico se realizó de forma ciega siguiendo un protocolo de cuantificación de lesión tisular basado en una escala. Los datos fueron analizados con el programa estadístico IBM SPSS Statistics.
Los resultados mostraron daño renal tubular, más pronunciado en la corteza externa, asociado al tratamiento con cisplatino, mientras que no hubo alteraciones estructurales en la monoterapia con ICI. El cotratamiento potenció el daño estructural renal del cisplatino. Esta potenciación fue más evidente en la región corticomedular, lo que sugiere que la combinación de fármacos provoca una lesión más profunda en el riñón.
Presente y futuro de la industria farmacéutica
Authors: Maderuelo Cristina 
Published: November 2022

En los últimos dos siglos, la industria farmacéutica ha experimentado una enorme evolución hacia una fabricación compleja de productos farmacéuticos y formas de dosificación muy sofisticadas acompañada de grandes cambios en las prácticas de fabricación y en las instalaciones, utilizando tecnologías avanzadas asociadas a estrictas normas de calidad. Este tránsito comúnmente se representa en cuatro 4 etapas. La industria farmacéutica se encuentra actualmente en la tercera de ellas, marcada por el fuerte desarrollo de los ordenadores y las tecnologías de la comunicación, siendo una realidad la fabricación en continuo, la tecnología analítica de procesos (PAT) y la calidad por diseño (QbD). La fabricación en continuo supone un flujo continuo integrado donde las operaciones básicas suceden simultáneamente, evitando paros, acortando procesos, minimizando la manipulación y el trasvase manual del producto, así como su exposición al ambiente. El PAT permite hacer un seguimiento analítico de los materiales de partida, intermedios y producto, en línea o muy cerca de la línea en poco tiempo, a tiempo real, sin parar el proceso. Algunos ejemplos del PAT son el uso del NIR o del RAMAN para la determinación del punto final de algunas operaciones básicas o la determinación en línea de las propiedades de las formas farmacéuticas, entre otros. La fabricación en continuo y el PAT suponen ventajas en términos de eficacia y de calidad, disminuyendo la variabilidad en los productos y su posible contaminación. Asociado a ellas se encuentra el QbD, metodología aplicable al desarrollo farmacéutico que permite establecer los factores críticos relacionados con los materiales y el proceso; llevar a cabo un diseño de experimentos más completo a partir de estos factores, y, tras el análisis de los resultados obtenidos, establecer el espacio de diseño, es decir, aquel espacio para cada factor dentro del cual se obtiene un producto de la calidad establecida previamente.
La fabricación en continuo, el QbD y el PAT sientan las bases para potenciar la denominada Farma 4.0, etapa en la que, a estos elementos, se unen otros como el Internet de las cosas (IoT), la inteligencia artificial, la robótica o la computación avanzada, que permitirán disponer de sistemas autónomos y autoorganizados que funcionan independientemente de la participación humana. Se prevé que, en un entorno de este tipo, seremos capaces de recoger una cantidad enorme y variada de datos que podrán analizarse mediante algoritmos y utilizarse para tomar decisiones en tiempo real que impactarán directamente en los resultados de producción.
Liofilización de liposomas para su administración pulmonar
Authors: Calderón García Blanca , De Jesús Valle María José 
Published: November 2022

El citrato de sildenafilo se ha convertido, en los últimos años, en un agente terapéutico oral utilizado para el tratamiento de la hipertensión arterial. Debido a que presenta ciertas limitaciones, como una reducción significativa de la biodisponibilidad oral y de la actividad farmacológica debido al metabolismo hepático de primer paso, se han propuesto formulaciones innovadoras para su administración por vía pulmonar, permitiendo minimizar los efectos adversos sistémicos y el efecto de primer paso.
El objetivo del trabajo es elaborar liposomas cargados de sildenafilo y posteriormente liofilizarlos. Además, evaluar las propiedades de flujo del producto sólido obtenido para su posible administración por vía pulmonar.
Los liposomas obtenidos fueron preparados mediante el método de sonicación-filtración, en ausencia de disolventes orgánicos y, por tanto, se consideran unos sistemas biocompatibles y biodegradables, muy adecuados para su posible administración por vía pulmonar. Presentaron una elevada eficacia de encapsulación de sildenafilo (EE% = 85).
Se observaron adecuados resultados de flujo del producto sólido con cada uno de los lioprotectores utilizados, obteniéndose valores de ángulo de reposo inferiores a 30º e índices de Carr (IC) también inferiores al 36 %.
Por tanto, la liofilización de liposomas juega un papel fundamental en la conservación y la estabilidad de dichas vesículas.
ROTAS ANALÍTICAS EM CÓDIGO DE ONTOLOGIA CRÍTICA
Authors: Jaramillo Oscar 
Published: November 2022

Neste texto são concebidas rotas analíticas desde os códigos foucaultianos sobre a ontologia crítica de nós mesmos, a qual tem como intuito inquirir sobre a forma na qual estamos sendo produzidos e nos significamos no meio deste presente que hoje nos permeia. Assim, estendem-se categorias de análise que podem ser usadas na pesquisa ontológica como eventualização e problematização, para continuar com a reflexão sobre as práticas de si antigas e a possibilidade de uma virada às práticas de si contemporâneas como rota adequada para analisar a produção de subjetividades na atualidade. Logo disso, propõe-se uma matriz analítica que volta e amplia a categoria de prática de si, proposta por Foucault trabalhando sobre as quatro dimensões que a constituem: substância ética, ligação à prática, tipo de prática e teologia do sujeito moral, além da dimensão que acrescenta Sáenz, agente da substancia ética. Estas, expandem-se desde os eixos genealógico, estético, relacional, pragmático e de mathesis ontológica. Em suma, estas categorias e dimensões são apresentadas em meio de uma reflexão que permite uma análise para problematizar as formas de governo da vida nos tempos que transcorrem, para ali, inteligir as relações de poder que operam no capitalismo neoliberal globalizado, como governo de uns homens sobre outros para acrescentar o controle sobre os sujeitos ou una prática de liberdade ético-política que atinge resistir ao poder desde o governo de si próprio.
Maternal use of methamphetamine induces sex‐dependent changes in myocardial gene expression in adult offspring
Authors: Dague Alex , Chavva Hasitha , Brazeau Daniel A. , Denvir James , Rorabaugh Boyd R. 
Published: November 2022

AbstractMethamphetamine is a commonly abused illicit stimulant that has prevalent use among women of child‐bearing age. While there are extensive studies on the neurological effects of prenatal methamphetamine exposure, relatively little is known about the effect of prenatal methamphetamine on the adult cardiovascular system. Earlier work demonstrated that prenatal methamphetamine exposure sex dependently (females only) sensitizes the adult heart to ischemic injury. These data suggest that prenatal exposure to methamphetamine may induce sex‐dependent changes in cardiac gene expression that persist in adult offspring. The goal of this study was to test the hypothesis that prenatal methamphetamine exposure induces changes in cardiac gene expression that persist in the adult heart. Hearts of prenatally exposed female offspring exhibited a greater number of changes in gene expression compared to male offspring (184 changes compared with 74 in male offspring and 89 changes common between both sexes). Dimethylarginine dimethylaminohydrolase 2 and 3‐hydroxybutyrate dehydrogenase 1 (genes implicated in heart failure) were shown by Western Blot to be under expressed in adult females that were prenatally exposed to methamphetamine, while males were deficient in 3‐Hydroxybutyrate Dehydrogenase 1 only. These data indicate that prenatal methamphetamine exposure induces changes in gene expression that persist into adulthood. This is consistent with previous findings that prenatal methamphetamine sex dependently sensitizes the adult heart to ischemic injury and may increase the risk of developing cardiac disorders during adulthood.
The Ebla Chancery Texts in the Light of Recent Linguistic Research
Authors: Arkhipov Ilya , Kogan Leonid 
Published: November 2022

AbstractThe article aims at establishing new, more reliable meanings and functions for a number of lexical and semi-grammatical elements of Eblaite (Syrian East Semitic). The so-called “chancery texts”, first published by Pelio Fronzaroli and Amalia Catagnoti as ARET 13, 16 and 18, are in the focus of the analysis. While feasible contextual interpretation is an absolute priority for the present authors, other (notably, comparative) methods are also used when applicable. As a result, a substantial progress in our understanding of these exceedingly difficult documents is expected to be achieved.
Penalized logistic regression with prior information for microarray gene expression classification
Authors: Genç Murat 
Published: November 2022

Abstract
Cancer classification and gene selection are important applications in DNA microarray gene expression data analysis. Since DNA microarray data suffers from the high-dimensionality problem, automatic gene selection methods are used to enhance the classification performance of expert classifier systems. In this paper, a new penalized logistic regression method that performs simultaneous gene coefficient estimation and variable selection in DNA microarray data is discussed. The method employs prior information about the gene coefficients to improve the classification accuracy of the underlying model. The coordinate descent algorithm with screening rules is given to obtain the gene coefficient estimates of the proposed method efficiently. The performance of the method is examined on five high-dimensional cancer classification datasets using the area under the curve, the number of selected genes, misclassification rate and F-score measures. The real data analysis results indicate that the proposed method achieves a good cancer classification performance with a small misclassification rate, large area under the curve and F-score by trading off some sparsity level of the underlying model. Hence, the proposed method can be seen as a reliable penalized logistic regression method in the scope of high-dimensional cancer classification.
Reception of Scripture in Rashi’s Torah Commentary
Authors: Eisenstat Yedida 
Published: November 2022

AbstractThe most influential biblical commentary in Jewish history is that of the late eleventh century scholar, Rabbi Shlomo Yitzḥaki (“Rashi”) of northern France. This essay examines Rashi’s Torah Commentary as a midrashic anthology and examines Rashi’s reception of the Bible through the lens of his use of midrash. After highlighting shared traits of first-millennium midrashic corpora and Rashi’s Torah Commentary, I offer a new reading of Rashi’s “methodological statement.” I then turn to Rashi’s historical context to suggest that the Commentary’s lemmatized form demonstrates that Scripture cannot be properly understood without its rabbinic accompaniment, the midrash of the rabbis’ Oral Torah. Finally, I offer examples of the range of ways Rashi employed midrash in his Commentary, the primary lens through which traditional Jews have received Scripture for a millennium.
Effect of carrier (hole) temperature on performance of optical amplifiers quantum dot structure
Authors: Ghazai Alaa Jabbar , Flayyih Ahmed H. , Attab Rasool R. , Al-Khursan Amin H. 
Published: November 2022

Abstract
Carriers temperature in quantum dot (QD) optical amplifiers has been modelled theoretically taken into account hole contribution, which is not considered early. The contributions of wetting layer (WL), first excited state (ES1), and second excited state (ES2) have also been considered. Effect of WL−ES2 recombination time of both electrons and holes, carrier heating (CH) time of electrons and holes, in addition to electron hole recombination time are examined. The results show that there is a gap between electron and hole heating temperature due to the difference between there recovery times. It is found that fast hole (long electron) recombination time yield a high carrier temperature.
Intracardiac thrombosis following intravenous zoledronate treatment in a child with steroid-induced osteoporosis
Authors: Case Samantha J. , Moon Rebecca J. , Bharucha Tara , Davies Justin H. 
Published: November 2022

Abstract

Objectives
Bisphosphonates are used in childhood osteoporosis but can cause an acute phase reaction (APR) and hypocalcemia. We present a child with cardiac thrombosis following zoledronate, a previously unreported complication.

Case presentation
An 11-year-old with Duchenne muscular dystrophy and steroid-induced osteoporosis presented 48 h after first zoledronate infusion with fever, tachycardia, tachypnoea and hypoglycaemia. This was managed as acute adrenal crisis and possible sepsis. He also had hypocalcemia, hypophosphatemia, hyponatraemia and hypokalaemia. Echocardiography performed due to persistent chest pain and tachycardia revealed a left ventricular thrombus.

Conclusions
Potential causes for intracardiac thrombosis in this patient include ventricular dysfunction due to acute adrenal crisis or electrolyte disturbance, and hypercoagulability due to the APR. Echocardiography should be considered in children with acute cardiovascular compromise following zoledronate. Stress-dose steroids to cover the APR and a reduced starting dose of zoledronate might have reduced the risk of this complication.
Developing and contributing to systemic functional translation studies in China: an interview with Professor Guowen Huang
Authors: Huang Guowen , Wang Bo , Ma Yuanyi 
Published: November 2022

Abstract
Systemic functional translation studies (SFTS) has been a research area sustained by scholars from both Systemic Functional Linguistics (SFL) and translation studies over the past decades. In China, there have been an increasing number of studies in SFTS after the 2000s, with Professor Guowen Huang being one of the pioneering and influential scholars contributing to this emerging research area. This paper is a transcript of an interview conducted with Guowen Huang and it serves to provide a general introduction to his research. In the interview, he discusses his motivation for exploring SFTS, the advantages of applying SFL to translation studies, and the Ph.D. students he has supervised over the past decades. He also introduces his own work on the translations of ancient Chinese poems, the translations of the Analects (Lunyu 论语) of Confucius, and his investigation of applying ecolinguistics to translation studies. Finally, he suggests some future studies needed in this area.
Unum, Verum, Bonum and the System Formation of Critical Philosophy
Authors: Nakano Hirotaka 
Published: November 2022

Abstract
This article deals with Kant’s intentions in adding § 12 of the second edition of the Critique of Pure Reason. Here, Kant remarks on the so-called transcendentals (unum, verum, bonum) in the metaphysical or ontological tradition. This article focuses on their trans-categorial character to clarify their role in the system formation of Kant’s three critiques. In order to clarify Kant’s difficult terminology in § 12, fragments from his reflections and transcripts of his lectures are analyzed. Furthermore, an examination of Kant’s references to qualitative unity, plurality, and perfection reveals that these logical criteria of cognition in general help him to organize the content of the three critiques.
Mechanical and heat transfer properties of 4D-printed shape memory graphene oxide/epoxy acrylate composites
Authors: Xu Jinghang , Chen Long , Yang Xue , Liu Zhanqiang , Song Qinghua 
Published: November 2022

Abstract
4D printing is a new technology to fabricate active smart materials, which can change the configuration according to environmental stimuli. To obtain shape memory graphene oxide/bisphenol A epoxy acrylate (GO/Bis-A EA) composites with outstanding shape memory properties and significant thermal conductivity, GO was introduced into Bis-A EA to prepare shape memory GO/Bis-A EA composites by light curing. Through the shape recovery and heat transfer experiments, the shape recovery rate and heating rate were tested to characterize the shape memory and heat transfer performance. The relationship between various influencing factors and the properties of composites were investigated, and the optimal fitting model was established to optimize the preparation process by setting shape recovery rate and heating rate as response values. The results showed that when the content of diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide was 4.4%, 1,6-hexanediol diacrylate/Bis-A EA was 0.6, curing power was 40 W, GO content was 0.05%, and curing time was 14 s, the shape recovery rate of the experiments was 87.22% with the heating rate being 0.1532°C/s. The predicted values of shape recovery rate and heating rate inferred by the response surface optimization model were 86.35% and 0.1520°C/s, respectively, which were within 2% error. Through the process optimization research, the 4D-printed shape memory GO/Bis-A EA can achieve excellent shape recovery and heat transfer performance to meet the application of shape memory composites in extreme environments.
American Spanish dizque from a Functional Discourse Grammar perspective
Authors: Olbertz Hella 
Published: November 2022

Abstract
This article discusses the diachronic development and the different uses of the reportative word dizque (diachronically based on diz que ‘she/he/it says that’) using data from Colombian and Mexican Spanish. The study presents a predominantly qualitative analysis of diachronic, twentieth- and twenty-first-century written data. The theoretical framework applied in this article is Functional Discourse Grammar (FDG), which is particularly useful in this context as it distinguishes between the interpersonal and representational functions of language. The main points made are: (i) dizque is an adverb that arose from a process of lexicalization rather than grammaticalization; (ii) in most of its uses, dizque has an interpersonal function in the sense that the Speaker instructs the Addressee that she/he is not the source of the information provided; (iii) by means of diachronic, dialectal, and typological data, it is shown that the scope of dizque is gradually decreasing; (iv) the only scope decrease that leads to a functional change of dizque is its application outside the context of speech-reports. FDG serves to account for each step in the scope decrease of dizque by means of its hierarchical approach to the actional and descriptive functions of verbal interaction.
Ethnic networks in the internationalization of Turkish food producers
Authors: Bagci Utku Eren , Franz Martin , Yavan Nuri 
Published: November 2022

Abstract
The Uppsala Internationalization Process Model falls short in its ability to explain how emerging market firms internationalize. In this respect, the model needs to be enhanced through theoretical and empirical contributions. In this study, we aimed to increase the relationality of the model by employing the ethnic networks approach. As a case study for emerging market companies, we focused on the internationalization processes of Turkish food companies, which have been relatively little studied until now. Based on data from qualitative interviews, we found that ethnic networks in Germany play an important role in the initial stages of export activities, in location selection, in gaining market information, and in reaching the mainstream retailers and consumers for Turkish food companies. Adopting the ethnic networks approach enables us to see the roles of previously ignored relationships. Our findings show that, in future research, the role of ethnic networks should not be overlooked in the process of applying the Uppsala Internationalization Process Model on emerging market firms.
From maximum force to physics in 9 lines and towards relativistic quantum gravity
Authors: Schiller Christoph 
Published: November 2022

AbstractA compact summary of present fundamental physics is given and evaluated. Its 9 lines describe all observations exactly and contain both general relativity and the standard model of particle physics. Their precise agreement with experiments, in combination with their extreme simplicity and their internal consistency, suggest that there are no experimental effects beyond the two theories. The combined properties of the 9 lines also imply concrete suggestions for the microscopic constituents in a complete theory of relativistic quantum gravity. It is shown that the microscopic constituents cannot be described by a Lagrangian or by an equation of motion. Finally, the 9 lines specify the only decisive tests that allow checking any specific proposal for such a theory.