bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between objective measures of physical function and serum lactate dehydrogenase in older adults with cancer prior to treatment
Authors: Papadopoulos Efthymios , Santa Mina Daniel , Abu Helal Ali , Alibhai Shabbir M. H. 
Published: October 2022

Background
Lactate dehydrogenase (LDH) reflects tumor burden and is a prognosticator of all-cause mortality in patients with cancer. Objective measures of physical function are associated with clinically relevant outcomes in older adults with cancer. However, whether physical function is associated with LDH in geriatric oncology is unknown. The objective of this study was to assess the relationship between objective measures of physical function and serum LDH in older adults with cancer prior to treatment.

Methods
Data from older adults with cancer prior to treatment were retrieved from an institutional database and medical records within a tertiary cancer centre. Physical function measures involved muscle strength and physical performance. Muscle strength and physical performance were assessed through grip strength and the Short Physical Performance Battery (SPPB), respectively. LDH was log transformed using the natural logarithm. Multivariable logistic regression was used to examine the relationship between objective measures of physical function and LDH prior to treatment in all participants. Stratified analyses were performed for participants with solid and hematological cancers.

Results
A total of 257 participants (mean age: 80.2y) were included in the analysis. Most participants were females (50.6%) and were diagnosed with locally advanced (26.8%), gastrointestinal disease (35.0%). The multivariable analysis indicated that SPPB was inversely associated with LDH in all participants (B = -0.019, 95%CI = -0.036 to -0.002, p = 0.028). Notably, the inverse relationship between SPPB and LDH persisted only in patients with hematological malignancies in the multivariable model of the stratified analysis (B = -0.049, 95%CI = -0.087 to -0.011, p = 0.013). Neither grip strength alone nor the combination of low grip strength and/or SPPB were associated with LDH. Compared to participants with metastatic disease, those with localized or locally advanced disease had lower serum LDH.

Conclusion
Physical performance is inversely associated with serum LDH in older adults with hematological cancers prior to treatment.
Positive solutions of a Kirchhoff–Schrödinger--Newton system with
critical nonlocal term
Authors: Zhou Ying , Lei Jun , Wang Yue , Xiong Zonghong 
Published: October 2022

This paper deals with the following Kirchhoff–Schrödinger–Newton
system with critical growth

{

−
M

(

∫

Ω

|

∇
u

|

2

d
x

)

Δ
u
=
ϕ

|

u

|

2
∗

−
3

u
+
λ

|

u

|

p
−
2

u
,

i
n

Ω
,

−
Δ
ϕ
=

|

u

|

2
∗

−
1

,

i
n

Ω
,

u
=
ϕ
=
0
,

o
n

∂
Ω
,

where
Ω

⊂

R

N

(
N
≥
3
)
is a smooth
bounded domain,
M
(
t
)
=
1
+
b

t

θ
−
1

with
t
>
0
,

1
<
θ
<

N
+
2

N
−
2

,
b
>
0
,
1
<
p
<
2
,
λ
>
0

is a parameter,

2
∗

=

2
N

N
−
2

is the critical Sobolev exponent. By
using the variational method and the Brézis–Lieb lemma, the existence and
multiplicity of positive solutions are established.
Midesophageal Metastatic Disease After Treatment of Gastroesophageal Junction Adenocarcinoma
Authors: Brotherton Tim , Burton Sam , Knoche Eric , Presti Michael 
Published: October 2022

ABSTRACT
Esophageal cancer carries a significant risk of morbidity and mortality because of its poor prognosis. Adenocarcinoma is the most common type of esophageal cancer in the United States. Local metastasis within the esophagus is extremely rare and likely because of the complex esophageal lymphatic system. Our patient is a 74-year-old man with adenocarcinoma of the gastroesophageal junction treated with chemotherapy and radiation who was subsequently found to have local metastasis to the proximal esophagus.
Colorectal Cancer After Screening Colonoscopy: 10-Year Incidence by Site and Detection Rate at First Repeat Colonoscopy
Authors: Schwarz Sarina , Hornschuch Michel , Pox Christian , Haug Ulrike 
Published: October 2022

INTRODUCTION:
We aimed to describe cumulative colorectal cancer (CRC) incidence after screening colonoscopy stratified by tumor location, age, and sex as well as CRC detection rate at first repeat colonoscopy.

METHODS:
Using the German Pharmacoepidemiological Research Database, we included persons with screening colonoscopy and assessed cumulative CRC incidence after baseline screening colonoscopy with snare polypectomy (cohort 1) and without polypectomy (cohort 2). We also determined the CRC detection rate at first repeat colonoscopy by time since screening colonoscopy.

RESULTS:
Overall, 1,095,381 persons were included. The 10-year cumulative CRC incidence was 1.5% in cohort 1 and 0.6% in cohort 2. The proportion of proximal CRC increased with age: In women of cohort 1, 47% of CRCs in the age group 55–64 years were proximal (men: 42%) while in the age group 65–74 years, this proportion was 55% (men: 49%). In cohort 2, similar patterns were observed. In cohort 1, the CRC detection rate at first repeat colonoscopy among persons examined within 6–8 years after screening colonoscopy was more than twice as high compared with those examined within 4–6 years (1.7% vs 0.8%).

DISCUSSION:
Among persons followed up after screening colonoscopy, we observed a steadily increasing predominance of proximal CRC, and this shift showed distinct patterns by age and sex. Because our study suggests higher CRC detection rates among persons with a later repeat colonoscopy, the role of delayed surveillance and the benefit of a reminder system should be explored.
Overlapping Transcriptional Profile in Proton Pump Inhibitor Responsive and Nonresponsive Eosinophilic Esophagitis
Authors: Hamilton Matthew J. , Muftah Mayssan , Goldin Alison H. , Lo Wai-Kit , Hsu Blatman Karen S. , Chan Walter W. , Srivastava Amitabh 
Published: October 2022

INTRODUCTION:
We compared esophageal mucosal gene transcript expression in proton pump inhibitor (PPI) responsive (PPI-R) eosinophilic esophagitis (EoE), PPI nonresponsive (PPI-NR) EoE, and healthy controls.

METHODS:
Transcript expression in midesophagus biopsies was determined using NanoString and a custom panel of EoE-specific genes. The top upregulated and downregulated genes with ≥2-fold difference in expression and statistically significant (P < 0.05) were identified.

RESULTS:
Nearly all the top upregulated (17 of 20) and downregulated (5 of 5) genes in EoE, compared with healthy controls, were shared between the PPI-R and PPI-NR groups.

DISCUSSION:
Esophageal mucosal transcript expressions are remarkably similar in PPI-R EoE and PPI-NR EoE compared with healthy controls.
Experimental Evaluation of Thermohydraulic Performance of Tubular Solar Air Heater
Authors: Midhat Yousif Fateh , Aljubury Issam Mohammed Ali 
Published: October 2022

The thermohydraulic performance of a new design solar air heater (SAH) design was examined experimentally in this paper as a trial to improve the flat-plate SAH’s efficiency. A flat-plate solar air heater (FPSAH) and a jacketed tubular solar air heater (JTSAH) having similar dimensions were constructed to compare their thermal performance efficiencies. A band of Aluminum jacketed tubes were arranged side by side in parallel to the airflow direction to form the absorber of a jacketed tubular solar air heater (JTSAH). The experiments were accomplished at three mass flow rates (MFR)s: 0.011 kg/s. 0.033 kg/s, and 0.055 kg/s. Results revealed that the maximum temperature difference was obtained from JTSAH at 38°C in comparison to 32°C from the FPSAH at MFR of 0.011 kg/s. The thermal losses from the upper glass cover of the JTSAH were less than the same losses at the FPSAH due to the reduced absorber and glass temperatures of the JTSAH. The gained power was higher at the JTSAH than the FPSAH. At the JTSAH, at 0.055 kg/s MFR, the maximum average thermal efficiency obtained was 81%, and the maximum average thermos-hydraulic efficiency obtained was 75.61 %. It is noted that increasing the MFR increases the thermal efficiency, also, its optimum value rises the thermos-hydraulic efficiency to a specific optimum point. The pressure drop increases with the MFR and JTSAH compared to the FPSAH
Effects of acute exercise training on tumor outcomes in men with localized prostate cancer: A randomized controlled trial
Authors: Djurhuus Sissal Sigmundsdóttir , Schauer Tim , Simonsen Casper , Toft Birgitte Grønkær , Jensen Adina Ruth Deborah , Erler Janine Terra , Røder Martin Andreas , Hojman Pernille , Brasso Klaus , Christensen Jesper Frank 
Published: October 2022

AbstractPostdiagnosis physical activity is associated with improved cancer outcomes, but biological mechanisms mediating anticancer effects remain unclear. Recent findings suggest that physiological adaptations to acute exercise comprise potential anticancer effects, but these remain poorly explored in clinical settings. The objective of this study was to explore the effects of a single exercise bout on tumor oxygenation and immune cell infiltration in patients with prostate cancer. Thirty patients with localized prostate cancer were randomized (2:1) to either one high‐intensity interval training bout or no exercise on the day before radical prostatectomy. Immunohistochemical analyses were performed on prostatic tissue from surgery and assessed for tumor hypoxia, natural killer (NK) cell infiltration, and microvessel density (MVD). Acute systemic response in blood lymphocytes, epinephrine, norepinephrine, IL‐6, tumor necrosis factor, cortisol, lactate, and glucose was also evaluated. We did not find between‐group differences in tumor hypoxia (Mann–Whitney U test, U = 83.5, p = 0.604) or NK cell infiltration (U = 77.0, p = 0.328). Also, no significant correlation was found between MVD and tumor hypoxia or NK cell infiltration. One exercise bout is likely insufficient to modulate tumor hypoxia or NK cell infiltration. Future studies may elucidate if an accumulation of several exercise bouts can impact these outcomes (NCT03675529, www.clinicaltrials.gov).
Synthesis of newer substituted chalcone linked 1,2,3-triazole analogs and evaluation of their cytotoxic activities
Authors: Raghavender Matta , Shankar Bhookya , Umapathi Nalla , Jalapathi Pochampally 
Published: October 2022

Abstract
An innovative heterocyclic biologically active chalcone 1,2,3-triazole analogs (6a–j) were prepared to extract excellent yields by coupling the substituted aryl azides (5a–5j) and 5-ethynyl-1,2,3-trimethoxybenzene, by using the method of Huisgen azide–alkyne cycloaddition. The typically synthesized analogs were elucidated by IR, 1H-nuclear magnetic resonance (NMR), 13C-NMR, and Electron spray ionization (ESI)-mass spectroscopy and tested for their cytotoxicity effectiveness in MTT assays against the A549 lung cancer cells. The cytotoxic studies suggested that a few analogs showed moderate to good activities. The compounds 6i and 6c showed low cytotoxicity against the A549 cell line among 12 analogs, the values of IC50 were displayed in the range of 65.05 ± 1.12 and 71.56 ± 1.29 µM, respectively. The compound 6j showed slightly less cytotoxicity but showed good selectivity against A549 cell lines.
Iterative learning control for conformable stochastic impulsive differential systems with randomly varying trial lengths
Authors: Qiu Wanzheng , Fečkan Michal , Wang JinRong , Shen Dong 
Published: October 2022

Abstract
In this paper, we introduce a new kind of conformable stochastic impulsive differential systems (CSIDS) involving discrete distribution of Bernoulli. For random discontinuous trajectories, we modify the tracking error of piecewise continuous variables by a zero-order holder. First, the improved P-type and PD

α
-type learning laws of the random iterative learning control (ILC) scheme are designed through global and local averaging operators. Next, we establish sufficient conditions for convergence of the tracking error in the expectation sense and prove the main results by using the impulsive Gronwall inequality and mathematical analysis tools. Finally, the theoretical results are verified by two numerical examples, and the tracking performance is compared for different conformable order of α.
Discussion on controllability of non-densely defined Hilfer fractional neutral differential equations with finite delay
Authors: Kavitha Krishnan , Vijayakumar Velusamy 
Published: October 2022

Abstract
This manuscript prospects the controllability of Hilfer fractional neutral differential equations. The new results are obtained by implementing a suitable fixed point approach and the technique of measures of noncompactness and the outcomes and facts belong to fractional theory. Firstly, we focus the controllability and extend the discussion with nonlocal conditions. Finally, an interesting example is proposed to illustrate our main obtained results.
Modeling and PID control of quadrotor UAV based on machine learning
Authors: Zhou Lirong , Pljonkin Anton , Singh Pradeep Kumar 
Published: October 2022

Abstract
The aim of this article was to discuss the modeling and control method of quadrotor unmanned aerial vehicle (UAV). In the process of modeling, mechanism modeling and experimental testing are combined, especially the motor and propeller are modeled in detail. Through the understanding of the body structure and flight principle of the quadrotor UAV, the Newton–Euler method is used to analyze the dynamics of the quadrotor UAV, and the mathematical model of the UAV is established under the small angle rotation. Process identifier (PID) is used to control it. First, the attitude angle of the model is controlled by PID, and based on this, the speed in each direction is controlled by PID. Then, the PID control of the four rotor aircraft with the center of gravity offset is simulated by MATLAB. The results show that the pitch angle and roll angle can be controlled by 5 degrees together without center of gravity deviation, and the PID can effectively control the control quantity and achieve the desired effect in a short time. Classical BP algorithm, classical GA-BP algorithm, and improved GA-BP algorithm were trained, respectively, with a total of 150 sets of training data, training function uses Levenberg-Marquardt (trainlm), and performance function uses mean squared error (MSE). In the background of the same noise, the improved GA-BP algorithm has the highest detection rate, classical GA-BP algorithm is the second, and classical BP algorithm is the worst. The simulation results show that the PID control law can effectively control the attitude angle and speed of the rotor UAV in the case of center of gravity deviation.
Generalized Munn rings
Authors: Guo Junying , Guo Xiaojiang 
Published: October 2022

AbstractGeneralized Munn rings exist extensively in the theory of rings. The aim of this note is to answer when a generalized Munn ring is primitive (semiprimitive, semiprime and prime, respectively). Sufficient and necessary conditions are obtained for a generalized Munn ring with a regular sandwich matrix to be primitive (semiprimitive, semiprime and prime, respectively). Also, we obtain sufficient and necessary conditions for a Munn ring over principal ideal domains to be prime (semiprime, respectively). Our results can be regarded as the generalizations of the famous result in the theory of rings that for a ringRR,RRis primitive (semiprimitive and semiprime, respectively) if and only if so isMn(R){M}_{n}\left(R). As applications of our results, we consider the primeness and the primitivity of generalized matrix rings and generalized path algebras. In particular, it is proved that a path algebra is a semiprime if and only if it is semiprimitive.
Imitation of human muscle by using an electromechanical system
Authors: Ünal Engin , Özcan Samet 
Published: October 2022

AbstractHumanity is increasingly approaching the dream of making humanoid robots that have been imaginary for many years with advancing technology. Designs that are close to perfect in humanoid or animal-like robots emerge with the research and development studies carried out by researchers on this subject. In order to develop these robots, the movement mechanism of humans and animals must be examined again. Robots will work in place of people and can be used in wars with the development of these systems. In this study, the usability and performance of the linear actuator, which is widely used in various mechatronic systems as a linear motion provider, in the artificial muscle mechanism have been tested. Moreover, it tried to create a similar prototype by examining the working logic of skeletal muscle. The different aspect of the study is to indicate how the motion energy can be gained without using the conventional motors that are used in robot technologies. The artificial musculature is formed by arranging the electromagnets in a row, leaving a gap between them. The desired length of movement is formed as a result of the activated electromagnets gaining magnetism and closing the gap. In the study, the maximum load that the artificial muscle can pull according to the given voltage was 130.18 N and the average maximum gap length of each sarcomere was 1.68 mm. The efficiency of artificial muscle was found to be 56% compared to human muscle.
Earing prediction of 2090-T3 aluminum-cups using a complete homogenous fourth-order polynomial yield function
Authors: Firat Mehmet , Şener Bora , Akşen Toros Arda , Esener Emre 
Published: October 2022

AbstractEaring can be described as difference in cup wall height due to planar anisotropy of the sheet metals, and both prediction and minimization of this defect are critical steps of drawing process design to save material and production costs due to additional trimming operations. The finite element (FE) method is a practical design tool in this context. The accuracy of FE analyses is directly dependent on modeling material deformations using an effective plasticity model. In this study, a homogeneous orthotropic fourth-order polynomial stress function is presented and implemented into Ls-Dyna FE software by a user-defined material subroutine to predict the earing evolution of a strongly anisotropic aluminum alloy (AA2090-T3) in cup drawing. Primarily, the parameters of the function were calibrated using test data. The effects of element size, number of through-thickness integration points, and time-step size were investigated separately on the drawn cup’s earing profile and thickness strain distributions. It was observed that mass scaling factor related to time step size has a significant impact on the cup height and profile. Finally, simulations were repeated with optimum parameters to assess the performance of the plasticity model. The yield criterion successfully predicted the cup profile, earing amplitude, and thickness strain distributions.
Role of semiconductor photo catalysts on mask pollution management
Authors: Karthikeyan Balakrishnan , Therasa Alphonsa Antonybaburajan , Vijayakumar Natesan , Vinoth Raja Antony Samy Jose 
Published: October 2022

Abstract
Covid 19 pandemic taught us many lessons. Wearing mask becomes an essential to save our lives. At the same time, management of mask wastages is becoming threat to the environment as they release harmful dyes and fibres. Here in this work we attempt to degrade the mask dyes from the surface of the mask using nano metal oxide based silicate photo catalysts. Two nanocomposites PbO-SiO2
and TiO2-SiO2
were studied on the degradation of coloured mask. The percentage degradation was found to be more than 90%. The results are encouraging so that the proposed catalysts can be used for coating on the masks or used as photo catalyst to degrade the used masks.
Influence of Reverted Austenite on Tensile Deformation and Fracture in 18Ni 250 Maraging Steel
Authors: Rohit Benjamin , Muktinutalapati Nageswara Rao 
Published: October 2022

Abstract
Overaging of C250 maraging steel leads to reversion of austenite. The percentage of reverted austenite in the microstructure increases with an increasing extent of overaging. The effect of volume fraction of reverted austenite on the deformation behavior during tensile testing was studied. Specimens in the solution-annealed condition of the steel were overaged using different temperature/time combinations to produce a range of reverted austenite volume fractions. Changes in the lattice parameter of the martensite phase as a function of overaging treatment were monitored. X-ray diffraction technique was used to measure the volume fraction of reverted austenite and monitor the changes in lattice parameter of martensite. True stress–true strain curves were calculated from the engineering stress–engineering strain diagrams obtained for different overaging treatments, and plots showing the rate of work hardening as a function of true strain were derived. The present investigation shows that the reverted austenite produced at 538°C and 620°C induces serrated flow during tensile testing, whereas reverted austenite produced at 510°C does not. It is believed that the reverted austenite formed at the two higher temperatures is not stable because of the relatively lower amount of nickel and transforms to martensite on tensile deformation, leading to serrated flow. After aging at 510°C and 538°C, after the initial steep drop in the work hardening rate, the rate remains nearly constant over a certain range of true strain before it starts dropping again. After aging at 620°C, in contrast, the work hardening rate continuously decreases with increasing true strain. The precipitates formed after aging at 510°C/538°C are believed to be important contributions to the occurrence of the plateau. The results show that not only the quantity of reverted austenite but also the temperature at which reversion took place influence the fracture mechanisms and fracture surface appearance.
Jesús Pena (1947-2021)
Authors: Mariño Ramón , Rio-Torto Graça 
Published: October 2022

O día 28 de outubro de 2021 faleceu o profesor Jesús Pena, catedrático da área de Lingua española da USC e membro do Consello de Redacción da revista Verba entre os anos 1991 e 2010.
Ramón Mariño, secretario primeiro e director despois da revista, rememora a súa relación persoal co mestre e co amigo.
Graça Rio-Torto, da Universidade de Coimbra, amiga e morfóloga como Jesús, evoca a súa traxectoria académica e lembra ao compañeiro e amigo que nos deixou.
Mario Oliva, su legado
Authors: Mora-Rodriguez Arnoldo 
Published: October 2022

En días recientes falleció un gran intelectual y dilecto amigo, catedrático de la UNA, Mario Oliva Medina. De origen chileno, vino a Costa Rica muy joven a consecuencia del golpe de estado fascista perpetrado por una junta militar presidida por el General Augusto Pinochet; estudió en la UNA en donde obtuvo la licenciatura en historia y luego el doctorado en Pensamiento y Cultura Latinoamericana; allí mismo ejerció como docente e investigador en el Instituto de Estudios Latinoamericanos (IDELA)

Publicado originalmente en: https://semanariouniversidad.com/suplementos/loslibros/mario-oliva-su-legado/
Tributo a Mario Oliva Medina: latinoamericano martiano
Authors: Rodriguez Pedro Pablo 
Published: October 2022

Desde 1984 impartió cátedra en los programas de licenciatura, maestría y doctorado en Estudios Latinoamericanos y pensamiento latinoamericano en la Facultad de Filosofía y Letras de su Universidad; ejerció como vicerrector de Extensión de la Universidad Nacional de2010 a 2015; y durante los cinco años siguientes dirigió el Instituto de Estudios Latinoamericanos de ese centro de educación superior.

Publicado originalmente en: http://www.josemarti.cu/tributo-a-mario-oliva-medina-latinoamericano-martiano/