bluuebunny/crossref_metadata_2025_split huggingface dataset:
Playing the story: Learning with young Children’s in/visible composing collaborations in outdoor narrative play
Authors: Lenters Kimberly , Mosher Ronna , MacDonald Jennifer 
Published: December 2022

In this article, we examine young children’s narrative play as posthuman, collaborative composing assemblages. Thinking with Tsing (2015), we re/consider collaboration as that which benefits from contamination and unruly edges as lively and generative places can help educators to notice and nurture that which easily goes unnoticed. We are guided by the question of what could be learned about generating literacy learning opportunities for young children in an outdoor program focused on setting up conditions for collaborative, narrative play. Posthuman perspectives deriving from the philosophical work of Deleuze and Guattari, often utilize the concept of the rhizome. However, following the scholarship of posthuman philosopher Anna Tsing and mycologist, Merlin Sheldrake, we turn to another more-than-human lifeform and introduce the construct of mycelial networks for posthuman literacy studies. For this study of children’s collaborative composing, we work with Tsing’s concepts of unruly edges and contamination as collaboration and introduce the concept of the in/visible. Taking up Tsing’s invitation to think differently about the construction of knowledge practices, we map and examine children’s collaborative storying by providing two vignettes, which together, comprise a rush of troubled stories. The troubled stories were part of an awakening for program facilitators, a space of four weeks in which they came to see that by attuning to the liveliness of the children’s movements, their understanding of collaborative narrative play was transformed. As relations between the human children and facilitators and the more-than-human vividly animate in this study, the in/visible moments that erupt along the interface between the domesticated and the wild can guide educators in planning and enacting young children’s literacy learning. To foster children’s collaborative composing, we assert, it is necessary to trust that storying occurs, for many children, in the underground, in/visible spaces that underpin the stories they play.
Peptidomimetics in cancer targeting
Authors: Gomari Mohammad Mahmoudi , Abkhiz Shadi , Pour Taha Ghantab , Lotfi Ehsan , Rostami Neda , Monfared Fatemeh Nafe , Ghobari Babak , Mosavi Mona , Alipour Behruz , Dokholyan Nikolay V. 
Published: December 2022

AbstractThe low efficiency of treatment strategies is one of the main obstacles to developing cancer inhibitors. Up to now, various classes of therapeutics have been developed to inhibit cancer progression. Peptides due to their small size and easy production compared to proteins are highly regarded in designing cancer vaccines and oncogenic pathway inhibitors. Although peptides seem to be a suitable therapeutic option, their short lifespan, instability, and low binding affinity for their target have not been widely applicable against malignant tumors. Given the peptides’ disadvantages, a new class of agents called peptidomimetic has been introduced. With advances in physical chemistry and biochemistry, as well as increased knowledge about biomolecule structures, it is now possible to chemically modify peptides to develop efficient peptidomimetics. In recent years, numerous studies have been performed to the evaluation of the effectiveness of peptidomimetics in inhibiting metastasis, angiogenesis, and cancerous cell growth. Here, we offer a comprehensive review of designed peptidomimetics to diagnose and treat cancer.
Principle and Control of Active Engine Mount Based on Magnetostrictive Actuator
Authors: Si Zhiyuan , Bai Xianxu ‘Frank’ , Qian Lijun , Chen Peng 
Published: December 2022

AbstractEngine mount system affects the automobile NVH performance. Active mounts would achieve excellent vibration isolation and relative displacement control performance in a broad frequency bandwidth by outputting controlled force to the mounting system. The actuator and control method of the active mounts determine the system performance. In this paper, an active mount based on the smart material, i.e., Terfenol-D rod, is proposed, which mainly includes three parts: rubber spring, magnetostrictive actuator (MA), and hydraulic amplification mechanism (HAM). Dynamic model of the active mount is correspondingly established. A state feedback control method based on x-LMS (Least-Mean-Square) algorithm is proposed as well. Specifically, with the consideration of the unmeasurable state parameters in the active mounting system, an x-LMS state feedback controller with the system state as the reference signal is constructed by employing Sage-Husa Kalman filter to realize the state estimation of the active mounting system. Then a detailed analysis of the proposed control method is conducted, with deriving iterative formula of tap-weight vector. Sequentially, the problem of the dependence on the excitation signal in the x-LMS algorithm is addressed. The feasibility and capability of the proposed control method are verified and evaluated by simulation of a two-degree-of-freedom active mounting system.
Promotion of Specific Single-Transverse-Mode Beam Characteristics for GaSb-Based Narrow Ridge Waveguide Lasers via Customized Parameter Design
Authors: Wang Tianfang , Yang Chengao , Chen Yihang , Shi Jianmei , Yu Hongguang , Su Xiangbin , Zhang Yu , Xu Yingqiang , Niu Zhichuan 
Published: December 2022

AbstractGaSb-based single-transverse-mode narrow ridge waveguide (RW) lasers with high power and simultaneous good beam quality have broad application prospects in the mid-infrared wavelength region. Yet its design and formation have not been investigated systematically, while the beam characteristics that affect their suitability for specific applications remain rarely analyzed and optimized. The present work addresses these issues by theoretically establishing a waveguide parameter domain that generalizes the overall possible combinations of ridge widths and etch depths that support single-transverse-mode operation for GaSb-based RW lasers. These results are applied to develop two distinct and representative waveguide designs derived from two proposed major optimization routes of model gain expansion and index-guiding enhancement. The designs were evaluated experimentally based on prototype 1-mm cavity-length RW lasers in the 1950 nm wavelength range, which were fabricated with waveguides having perpendicular ridge and smooth side-walls realized through optimized dry etching conditions. The model gain expanded RW laser design with a relatively shallow-etched (i.e., 1.55 $$\upmu$$
μ
m) and wide ridge (i.e., 7 $$\upmu$$
μ
m) yielded the highest single-transverse-mode power to date of 258 mW with a narrow lateral divergence angle of 11.1$$^\circ$$

∘

full width at half maximum at 800 mA under room-temperature continuous-wave operation, which offers promising prospects in pumping and coupling applications. Meanwhile, the index-guiding enhanced RW laser design with a relatively deeply etched (i.e., 2.05 $$\upmu$$
μ
m) and narrow ridge (i.e., 4 $$\upmu$$
μ
m) provided a highly stable and nearly astigmatism-free fundamental mode emission with an excellent beam quality of M$$^2$$

2

factor around 1.5 over the entire operating current range, which is preferable for seeding external cavity applications and complex optical systems.
Isolated right ventricular Takotsubo cardiomyopathy in Guillain–Barré syndrome
Authors: Song Xiaojing , Chi Cheng , Song Junxian , Zhu Jihong 
Published: December 2022

Abstract
Background
Takotsubo cardiomyopathy can present itself in the most varied clinical forms, with extremely variable electrocardiogram anomalies and presence of comorbidities with a significant systemic commitment. Guillain–Barré Syndrome concomitant with isolated right ventricular Takotsubo cardiomyopathy is a rare entity. Here we present a patient with Guillain–Barré syndrome who had electrocardiogram abnormalities consistent with isolated right ventricular Takotsubo cardiomyopathy which have not been described in literature. This case report may prompt early identification of right ventricular involvement in neurological comorbidities, especially if the electrocardiogram is not frankly suggestive of an acute ischemic condition linked to coronary artery disease.

Case presentation
A 37-year-old woman was misdiagnosed as acute coronary syndrome because of abnormally elevated troponin T level and electrocardiogram findings in the Emergency Department. Due to absence of any significant stenosis in the main coronary artery, the primary diagnosis was ruled out. Based on reanalysis of the ECG abnormalities, the patient was diagnosed as a case of isolated right ventricular Takotsubo cardiomyopathy in Guillain–Barré Syndrome. This case demonstrates the importance of electrocardiogram as a critical tool to identify isolated right ventricular Takotsubo cardiomyopathy in Guillain–Barré Syndrome. Indeed, in this case, the electrocardiogram abnormalities were distributed beyond the territory of a single coronary artery distribution.

Conclusions
The described electrocardiogram findings of isolated right ventricular Takotsubo cardiomyopathy in Guillain–Barré Syndrome may facilitate identification of right ventricular involvement in neurological diseases.
Anemia and opportunistic infections in hospitalized people living with HIV: a retrospective study
Authors: Xie Bo , Huang Wei , Hu Yanling , Dou Yanyun , Xie Luman , Zhang Yong , Qin Shanfang , Lan Ke , Pang Xianwu , Qiu Hong , Li Lanxiang , Wei Xihua , Liu Zengjing , Meng Zhihao , Lv Jiannan 
Published: December 2022

Abstract
Background
There is a high prevalence of anemia among people living with HIV in Guangxi, China. Therefore, we investigated anemia and opportunistic infections in hospitalized people living with HIV and explored the risk factors related to anemia in people living with HIV to actively prevent anemia in people living with HIV.

Methods
We retrospectively studied people living with HIV admitted to Guangxi Chest Hospital from June 2016 to October 2021. Detailed information on the sociodemographic and clinical features of the participants was collected. The X2 test was used to compare the prevalence between the anemic and non-anemic groups. The logistic regression analysis was applied to exclude confounding factors and identify factors related to anemia.

Results
Among 5645 patients with HIV, 1525 (27.02%) had anemia. The overall prevalence of mild, moderate, and severe anemia was 4.66%, 14.08%, and 8.27%, respectively. The factors significantly related to increased risk of anemia were CD4 count < 50 cells/µl (aOR = 2.221, 95% CI = [1.775, 2.779]), CD4 count 50–199 cells/µl (aOR = 1.659, 95% CI = [1.327, 2. 073]), female (aOR = 1.644, 95% CI = [1.436, 1.881]) co-infected with HCV (aOR = 1.465, 95% CI = [1.071, 2.002]), PM (aOR = 2.356, 95% CI = [1.950, 2.849]), or TB (aOR = 1.198, 95% CI = [1.053, 1.365]).

Conclusions
Within Guangxi of China, 27.02% of hospitalized people living with HIV presented with anemia. Most patients with anemia were in the mild to moderate stage. The low CD4 count, female gender, and concomitant infection with Penicillium marneffei, Hepatitis C virus, or Tuberculosis were independent correlates of anemia. Thus, these findings would be helpful to clinicians in preventing and intervening in anemia in people living with HIV.
Cost-effectiveness of 3-months isoniazid and rifapentine compared to 9-months isoniazid for latent tuberculosis infection: a systematic review
Authors: Lai Wendy A. , Brethour Kaitlyn , D’Silva Olivia , Chaisson Richard E. , Zwerling Alice A. 
Published: December 2022

Abstract
Background
We conducted a systematic review examining the cost effectiveness of a 3-month course of isoniazid and rifapentine, known as 3HP, given by directly observed treatment, compared to 9 months of isoniazid that is directly observed or self-administered, for latent tuberculosis infection. 3HP has shown to be effective in reducing progression to active tuberculosis and like other short-course regimens, has higher treatment completion rates compared to standard regimens such as 9 months of isoniazid. Decision makers would benefit from knowing if the higher up-front costs of rifapentine and of the human resources needed for directly observed treatment are worth the investment for improved outcomes.

Methods
We searched PubMed, Embase, CINAHL, LILACS, and Web of Science up to February 2022 with search concepts combining latent tuberculosis infection, directly observed treatment, and cost or cost-effectiveness. Studies included were in English or French, on human subjects, with latent tuberculosis infection, provided information on specified anti-tubercular therapy regimens, had a directly observed treatment arm, and described outcomes with some cost or economic data. We excluded posters and abstracts, treatment for multiple drug resistant tuberculosis, and combined testing and treatment strategies. We then restricted our findings to studies examining directly-observed 3HP for comparison. The primary outcome was the cost and cost-effectiveness of directly-observed 3HP.

Results
We identified 3 costing studies and 7 cost-effectiveness studies. The 3 costing studies compared directly-observed 3HP to directly-observed 9 months of isoniazid. Of the 7 cost-effectiveness studies, 4 were modelling studies based in high-income countries; one study was modelled on a high tuberculosis incidence population in the Canadian Arctic, using empiric costing data from that setting; and 2 studies were conducted in a low-income, high HIV-coinfection rate population. In five studies, directly-observed 3HP compared to self-administered isoniazid for 9 months in high-income countries, has incremental cost-effectiveness ratios that range from cost-saving to $5418 USD/QALY gained. While limited, existing evidence suggests 3HP may not be cost-effective in low-income, high HIV-coinfection settings.

Conclusion
Cost-effectiveness should continue to be assessed for programmatic planning and scale-up, and may vary depending on existing systems and local context, including prevalence rates and patient expectations and preferences.
People with diabetes adherence to drug, dietary, and lifestyle changes in Erbil city, Iraq
Authors: Saleh Abubakir Majeed 
Published: December 2022

Abstract
Background
Since diabetes has serious complications that might result in life-long handicaps or even death, it is vital to ensure that people have reasonable control of the disease, which is eventually by good adherence to drugs, diet, and a good lifestyle. People non-adherence to any part of the therapy program for diabetes might result in worsening the condition. This study aimed to evaluate the compliance of people with diabetes to drug, diet, and lifestyle changes in Erbil city, Iraq.

Patients and methods
A descriptive cross-sectional study was conducted among a sample of 288 people with diabetes visiting Layla Qasim Health Center for people with diabetes in Erbil city, Iraq. Data were collected by interviewing the participants and filling out a questionnaire. The survey demonstrated the socio-demographic status, history, information about the participant's condition, frequency of self-monitoring, medication use, the impact of the surroundings and people's concerns, diet, and lifestyle of the participants.

Results
Of 202 participants responded to the questionnaire, 56.9% were female. The mean age was 52.53 ± 13.882 years. 85.6% of the participants were taking the medication regularly, and 78.8% of the participants followed a recommended diet by their doctors. Only 56.4% were exercising, with a majority being male, 70.1%.A strong association was found between gender and doing exercise, educational level and taking the medication regularly, duration of the disease, and following the recommended diet.

Conclusions
The adherence to taking the medication regularly is high, in which single most important cause is following up with their doctors. In contrast, adherence to lifestyle recommendations was suboptimal and essential in managing diabetes. Another reason is that educational level plays a role in understanding the importance of following the recommended lifestyle by the doctor.
Career expectations and the motivating factors for studying dentistry in Libya
Authors: Arhoma Niroz , Tantawi Maha El , Arheiam Arheiam 
Published: December 2022

Abstract
Introduction
This study investigated entry-level dental students’ motives for studying dentistry at the University of Benghazi (UoB), Libya and career expectations among recent UoB graduates in an atypical context during the time of political unrest and identified factors associated with these motives.

Methods
A cross-sectional survey was conducted in 2021–2022 for all entry-level dental students and recent dental graduates of UoB. A self-administered survey explored motives for studying dentistry, career expectation and associated factors. The questions were adopted from previous studies and pre-validated for use among Libyan students. Motives and career expectations were summarized, and their association with potential associated factors were assessed using chi-square test at p ≤ 0.05.

Results
One hundred eighty-four entry-level students and 156 recent graduates completed the surveys, response rates = 73.6% and 62.4%, respectively. The main motives to study dentistry were the desire to work in the healthcare field (183, 99.4%), interest in scientific knowledge (178, 96.7%) and because there were various dental specialities (168, 91.3%). The most common career expectations were setting up a business (107, 68.6%) and establishing a dental clinic (105, 67.3%). In addition, preference for working in the public sector (106, 67.9%), work-life balance (102, 65.4%) and financial gain (94, 60.3%) were the main factors associated with career expectations.

Conclusion
The main motive to join a dental school in Libya was academic interest. However, recent graduates showed more pragmatic expectations related to private practice ownership.
Moving toward a standardized diagnostic statement of pituitary adenoma using an information extraction model: a real-world study based on electronic medical records
Authors: Zhou Jingya , Guo Xiaopeng , Duan Lian , Yao Yong , Shang Yafei , Wang Yi , Xing Bing 
Published: December 2022

Abstract
Purpose
Diagnostic statements for pituitary adenomas (PAs) are complex and unstandardized. We aimed to determine the most commonly used elements contained in the statements and their combination patterns and variations in real-world clinical practice, with the ultimate goal of promoting standardized diagnostic recording and establishing an efficient element extraction process.

Methods
Patient medical records from 2012 to 2020 that included PA among the first three diagnoses were included. After manually labeling the elements in the diagnostic texts, we obtained element types and training sets, according to which an information extraction model was constructed based on the word segmentation model “Jieba” to extract information contained in the remaining diagnostic texts.

Results
A total of 576 different diagnostic statements from 4010 texts of 3770 medical records were enrolled in the analysis. The first ten diagnostic elements related to PA were histopathology, tumor location, endocrine status, tumor size, invasiveness, recurrence, diagnostic confirmation, Knosp grade, residual tumor, and refractoriness. The automated extraction model achieved F1-scores that reached 100% for all ten elements in the second round and 97.3–100.0% in the test set consisting of an additional 532 diagnostic texts. Tumor location, endocrine status, histopathology, and tumor size were the most commonly used elements, and diagnoses composed of the above elements were the most frequent. Endocrine status had the greatest expression variability, followed by Knosp grade. Among all the terms, the percentage of loss of tumor size was among the highest (21%). Among statements where the principal diagnoses were PAs, 18.6% did not have information on tumor size, while for those with other diagnoses, this percentage rose to 48% (P < 0.001).

Conclusion
Standardization of the diagnostic statement for PAs is unsatisfactory in real-world clinical practice. This study could help standardize a structured pattern for PA diagnosis and establish a foundation for research-friendly, high-quality clinical information extraction.
Key informants’ perspectives on policy- and service-level challenges and opportunities for delivering adolescent and youth-friendly health services in public health facilities in a Nigerian setting
Authors: Arije Olujide , Hlungwani Tintswalo , Madan Jason 
Published: December 2022

Abstract
Background
Integrating the care of adolescents and young people into existing public health facilities requires deliberate efforts to address challenges related to policy and service provision. This study assessed key informants’ perspectives on policy- and service-level challenges, and opportunities, for implementing a strategic framework for adolescent and youth-friendly health services (AYFHS) in public health facilities in a Nigerian setting.

Methods
Seventeen key informants were interviewed including members of the Adolescent sexual and reproductive health (ASRH) Technical Working Group (TWG), program managers of non-governmental organizations (NGO), State and local level health officials, and youth representatives, in Ogun State, Southwest Nigeria.

Result
Findings from this study indicate that some health workers continue to have a negative attitude toward young people’s sexual and reproductive health. There was some level of inclusion of adolescents and young people living with disabilities in ASRH programming which is welcome and extremely important. Some of the challenges in ASRH service provision included insufficient coordination of activities of donors/partners working in the adolescent health space. Also found was the missed opportunity to strengthen policy implementation with research, and the need for increased focus on mental health, substance use, and other aspects of adolescent and young people’s health. There was noted the opportunity to explore the Basic Health Care Provisions Funds (BHCPF) as a new source of funding for health services for AYP in Nigeria.

Conclusion
This study provided the context of the implementation of a strategic framework for adolescent reproductive health in a Nigerian setting from the perspectives of policy and service-level stakeholders. Opportunities for improving program delivery identified include ensuring research-based policy implementation and seeking program sustainability through tapping into new sources of funding.