bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the PID-5 depressivity personality dimensions and depressive symptomatology in a community sample
Authors: Gonçalves Bruno , Pires Rute , Henriques-Calado Joana , Sousa Ferreira Ana 
Published: September 2022

The alternative model for the classification of personality disorders presented in the DSM-5 is based on the hypothesis of continuity between normal personality and personality disorders. The main objective of this study is to analyze the relationship between depressive symptomatology and the domains and facets of the PID-5, especially the Depressivity facet. A convenience sample of the general population (N = 453) was used. Participants responded to the PID-5 and the CES-D. In a multiple regression model including all the PID-5 facets, only Depressivity and Anhedonia had a significant individual effect on predicting the CES-D score. Correlation analysis suggested that Depressivity and Anhedonia could be considered as defining the depressive traits of personality disorders and supported the continuity between these disorders and depressive symptomatology. A Taxometric Analysis with the Depressivity facet and CES-D score as indicators supported the dimensional nature of depressivity in a broad sense (depressive traits/ depressive symptomatology).
El modelo alternativo para la clasificación de los trastornos de la personalidad presentado en el DSM-5 se basa en la hipótesis de continuidad entre la personalidad normal y los trastornos de la personalidad. El objetivo principal de este estudio es analizar la relación entre la sintomatología depresiva y los dominios y facetas del PID-5, especialmente la faceta Depresión. Se utilizó una muestra de conveniencia de la población general (N = 453). Los participantes respondieron al PID-5 y a la CES-D. En un modelo de regresión múltiple que incluía todas las facetas de PID-5, solo la Depresión y la Anhedonia tuvieron un efecto individual significativo en la predicción de la puntuación CES-D. El análisis de correlación sugirió que la Depresión y la Anhedonia podrían considerarse como la definición de los rasgos depresivos de los trastornos de la personalidad y apoyó la continuidad entre estos trastornos y la sintomatología depresiva. Un análisis taxométrico con la faceta Depresión y la puntuación CES-D como indicadores respaldó la naturaleza dimensional de la depresión en un sentido amplio (rasgos depresivos / sintomatología depresiva).
The Bem Sex-Role Inventory: Proposal of a short version in Spanish
Authors: Gómez Berrocal Carmen , Cervilla Oscar , Álvarez-Muelas Ana , Sierra Juan Carlos 
Published: September 2022

The study objective was to examine the factorial structure, reliability and to provide some evidence for validity of the Spanish version of the Bem Sexual Roles Inventory (BSRI), which assesses self-description in terms of gender traits. A sample of 2,672 Spanish participants, heterosexual adults (1,289 men, 1,383 women) distributed into four age groups (18-25, 26-35, 36-55, 56 years or more), completed a Spanish 40-item version of BSRI. An 8-item scale is proposed with a two-dimensional structure: Masculinity (M) and Femininity (F). Both factors present adequate reliabi-lity. Regarding evidence for validity, men (vs. women) scored higher in M, and women (vs. men) in F. The M scores were higher for the participants aged less than 56 years. No differences were found in the F scores among age groups. We discuss the usefulness of this measure to assess interindividual differences, across sex and age, in the self-attribution of traditional gender traits.
El objetivo del estudio fue examinar la estructura factorial, la confiabilidad y proporcionar alguna evidencia de validez de la versión en español del Inventario de Roles Sexuales de Bem (BSRI), que evalúa la autodescripción en términos de rasgos de género. Una muestra de 2.672 participantes españoles, adultos heterosexuales (1.289 hombres, 1.383 mujeres) distribuidos en cuatro grupos de edad (18-25, 26-35, 36-55, 56 años o más), completó una versión en español de 40 ítems del BSRI. Se propone una escala de 8 ítems con estructura bidimensional: Masculinidad (M) y Feminidad (F). Ambos factores presentan una fiabilidad adecuada. Con respecto a la evidencia de validez, los hombres (vs. las mujeres) obtuvieron puntuaciones más altas en M y las mujeres (vs. los hombres) en F. Las puntuaciones M fueron más altas para los participantes menores de 56 años. No se encontraron diferencias en las puntuaciones F entre grupos de edad. Discutimos la utilidad de esta medida para evaluar las diferencias interindividuales, según el sexo y la edad, en la autoatribución de los rasgos de género tradicionales.
Women and videogames: What do they play?
Authors: Labrador Francisco J. , Fernández-Arias Ignacio , Martín-Ruipérez Sofía , Bernaldo-de-Quirós Mónica , Vallejo-Achón Marina , Sánchez-Iglesias Iván , Labrador Marta , Estupiñá Francisco J. 
Published: September 2022

The information on the use of Videogames (VG) in general samples fundamentally reflects the characteristics of men, because of their greater participation in VG, making it difficult to identify the characteristics of women and their gaming activity. Objective: To describe the gaming behaviour of adolescent and young women in Madrid, and its relation with the development of gaming problems. Method: A self-report questionnaire (Gamertest) was applied to a sample of 1,228 women (12 - 22 years old) (M = 14.84; SD = 2.469), selected by randomized sampling in schools in the Community of Madrid. Results: 51% of women admit gaming. The typical profile is a woman who plays VG sporadically and for short periods of time, preferably Action and Adventure games or Puzzles and Platforms, mainly on smartphones, at home and alone, with the purpose of having fun. The main predictive variables of gaming problems, identified with the Internet Gaming Disorder (IGD) in women are: a greater number of hours of use, playing Massively Multiplayer Online Role-Playing Game (MMORPG), and Strategy VG. The most protective factor is playing VG accompanied. The results are discussed.
La información sobre el uso de Videojuegos (VJ) en muestras generales refleja fundamentalmente las características de los hombres, por su mayor participación en VJ, dificultando identificar las características de las mujeres y su actividad de juego. Objetivo: Describir el comportamiento lúdico de adolescentes y jóvenes madrileñas y su relación con el desarrollo de problemas de juego. Método: Se aplicó un cuestionario de autoinforme (Gamertest) a una muestra de 1.228 mujeres (12 - 22 años) (M = 14.84; DT = 2.469), seleccionadas mediante muestreo aleatorio en centros educativos de la Comunidad de Madrid. Resultados: el 51% de las mujeres admite jugar. El perfil típico es una mujer que juega a VJ de forma esporádica y por cortos periodos de tiempo, preferiblemente juegos de Acción y Aventura o Puzles y Plataformas; principalmente en smartphones, en casa y sola, con el propósito de divertirse. Las principales variables predictivas de problemas de juego, identificadas con el Trastorno del Juego de Internet (TJI) en mujeres son: mayor número de horas de uso, participación en juegos de rol multijugador masivo online (MMORPG) y VJ de estrategia. El factor protector más importante es jugar a VJ acompañado. Se discuten los resultados.
Factorial analysis and gender invariance of GPIUS2 scale and evaluation of Caplan’s cognitive-behavioral model of problematic Internet use in adolescents
Authors: Marzo Juan C. , García-Oliva Carlos , Piqueras Jose A 
Published: September 2022

Caplan's (2010) revised cognitive-behavioral model of Problematic Internet Use (PIU) has become one of the most promising theoretical frameworks on such behavior in the last decade. The Generalized Problematic Internet Use Scale (GPIUS2) (Caplan, 2010) has been adapted and validated for use with Spanish adolescents, but gender invariance has not been tested yet in this country. The present study focuses on three objectives: to confirm the factorial structure of GPIUS2, to analyze gender invariance, and to test Caplan’s theoretical model, in a sample of Spanish adolescents. A cross-sectional study was carried out. The sample was composed of 909 participants from Spain, aged between 12 and 18 years (Mean age = 14.2, SD = 1.6). The results indicated a good fit of the GPIUS2 factor structure and gender factorial invariance. Moreover, the cognitive-behavioral model fit the data. GPIUS2 has a very good structure and presents gender factorial invariance, which favors its application in Spanish adolescent population. This study supports the cognitive-behavioral model of PIU.
El modelo cognitivo-conductual revisado de Caplan (2010) sobre el Uso Problemático de Internet (UPI) es uno de los marcos teóricos más prometedores sobre dicho comportamiento en la última década. La Escala Uso Problemático de Internet Generalizado (GPIUS2) (Caplan, 2010) ha sido adaptada y validada para su uso con adolescentes españoles, pero aún no se ha comprobado su invarianza de género en España. El presente estudio se centra en tres objetivos: confirmar la estructura factorial de la escala GPIUS2, analizar la invarianza de género de dicha escala y poner a prueba el modelo teórico de Caplan en una muestra de adolescentes españoles. Se realizó un estudio transversal. La muestra estuvo compuesta por 909 participantes de España, con edades comprendidas entre los 12 y los 18 años (Edad media = 14.2, DT = 1.6). Los resultados indicaron un buen ajuste de la estructura factorial del GPIUS2 e invarianza factorial en función del género. Además, el modelo cognitivo-conductual mostró un buen ajuste de los datos. La GPIUS2 tiene una muy buena estructura y presenta invarianza factorial para el género, lo que favorece su aplicación en la población adolescente española. Este estudio apoya el modelo cognitivo-conductual en el UPI.
Assessment of Technological Capabilities of the Informal Foodservice Operators in Oyo State
Authors: Adedeji Funke, T. , Taiwo Kehinde, A. , Ilori Matthew, O. 
Published: September 2022

Aim and Objective: Evaluate the technological capability of the informal foodservice operators in the study area with the view of ensuring wholesome food are served using the right technological capabilities.
The informal foodservice operators (IFOs) carry a larger part of food service providers that have contact with people on daily basis. The model of Garvin, 1981 was adapted for the study and mixed study approach. A structured questionnaire that includes both close and open-ended questions was used to elicit information from the participants of the study. The data collected was analysed and it showed that the technological capacity of the informal foodservice operators in studied areas in Oyo State was fairly high. The informal foodservice operators have low investment capacity, production capacity and high marketing capacity. The ability to use technological capacity to their advantage was lacking due to lack of funds and training. Their high marketing and innovation capacity showed that if there are funds and training, they will improve their investment and production capacity. Government should formulate policy that will encourage growth of the informal foodservice operators to ensure that wholesome food is served within the system.
Novel Temperature‐Sensitive Hydrogel Promotes Wound Healing Through YAP and MEK‐Mediated Mechanosensitivity
Authors: Li Ze , Huang Jinjian , Jiang Yungang , Liu Ye , Qu Guiwen , Chen Kang , Zhao Yun , Wang Peige , Wu Xiuwen , Ren Jianan 
Published: September 2022

AbstractWound healing is a significant problem in clinical management. Various functional dressings are studied to promote wound healing through biochemical factors. They are generally expensive, complex to fabricate, and may adversely affect the wound. Mechanical forces are the critical regulators of tissue repair. Although contraction is shown to promote wound healing, the underlying mechanisms are not fully understood. In this study, a novel adhesive temperature‐sensitive mechanically active hydrogel with a simple and inexpensive preparation process is developed. The dressing is able to adhere to the wound surface and actively contract the wound in response to body temperature. This mechanical contraction enhances the proliferative activity of basal cells, reduces the inflammatory response of the wound, and promotes wound healing. Furthermore, RNA‐seq clarifies how the gene regulatory network is regulated by contraction. Finally, using pharmacological inhibitors, YAP and MEK are identified as the key signaling molecules for contraction‐mediated tissue healing in vivo.
Manganese‐Based Tumor Immunotherapy
Authors: Zhang Ke , Qi Chao , Cai Kaiyong 
Published: September 2022

AbstractAs an essential micronutrient, manganese (Mn) participates in various physiological processes and plays important roles in host immune system, hematopoiesis, endocrine function, and oxidative stress regulation. Mn‐based nanoparticles are considered to be biocompatible and show versatile applications in nanomedicine, in particular utilized in tumor immunotherapy in the following ways: 1) acting as a biocompatible nanocarrier to deliver immunotherapeutic agents for tumor immunotherapy; 2) serving as an adjuvant to regulate tumor immune microenvironment and enhance immunotherapy; 3) activating host's immune system through the cGAS‐STING pathway to trigger tumor immunotherapy; 4) real‐time monitoring tumor immunotherapy effect by magnetic resonance imaging (MRI) since Mn2+ ions are ideal MRI contrast agent which can significantly enhance the T1‐weighted MRI signal after binding to proteins. This comprehensive review focuses on the most recent progress of Mn‐based nanoplatforms in tumor immunotherapy. The characteristics of Mn are first discussed to guide the design of Mn‐based multifunctional nanoplatforms. Then the biomedical applications of Mn‐based nanoplatforms, including immunotherapy alone, immunotherapy‐involved multimodal synergistic therapy, and imaging‐guided immunotherapy are discussed in detail. Finally, the challenges and future developments of Mn‐based tumor immunotherapy are highlighted.
Optical Memory, Switching, and Neuromorphic Functionality in Metal Halide Perovskite Materials and Devices
Authors: Vats Gaurav , Hodges Brett , Ferguson Andrew J. , Wheeler Lance M. , Blackburn Jeffrey L. 
Published: September 2022

AbstractMetal halide perovskite based materials have emerged over the past few decades as remarkable solution‐processable optoelectronic materials with many intriguing properties and potential applications. These emerging materials have recently been considered for their promise in low‐energy memory and information processing applications. In particular, their large optical cross‐sections, high photoconductance contrast, large carrier‐diffusion lengths, and mixed electronic/ionic transport mechanisms are attractive for enabling memory elements and neuromorphic devices that are written and/or read in the optical domain. Here, recent progress toward memory and neuromorphic functionality in metal halide perovskite materials and devices where photons are used as a critical degree of freedom for switching, memory, and neuromorphic functionality is reviewed.
Nanomaterials‐Mediated Co‐Stimulation of Toll‐Like Receptors and CD40 for Antitumor Immunity
Authors: Yan Jingyue , Zhang Yuebao , Du Shi , Hou Xucheng , Li Wenqing , Zeng Chunxi , Zhang Chengxiang , Cheng Jeffrey , Deng Binbin , McComb David W. , Zhao Weiyu , Xue Yonger , Kang Diana D. , Cheng Xiaolin , Dong Yizhou 
Published: September 2022

AbstractToll‐like receptors (TLRs) and CD40‐related signaling pathways represent critical bridges between innate and adaptive immune responses. Here, an immunotherapy regimen that enables co‐stimulation of TLR7/8‐ and CD40‐mediated pathways is developed. TLR7/8 agonist resiquimod (R848) derived amino lipids, RAL1 and RAL2, are synthesized and formulated into RAL‐derived lipid nanoparticles (RAL‐LNPs). The RAL2‐LNPs show efficient CD40 mRNA delivery to DCs both in vitro (90.8 ± 2.7%) and in vivo (61.3 ± 16.4%). When combined with agonistic anti‐CD40 antibody, this approach can produce effective antitumor activities in mouse melanoma tumor models, thereby suppressing tumor growth, prolonging mouse survival, and establishing antitumor memory immunity. Overall, RAL2‐LNPs provide a novel platform toward cancer immunotherapy by integrating innate and adaptive immunity.
Room Temperature Phase Transition of W‐Doped VO2 by Atomic Layer Deposition on 200 mm Si Wafers and Flexible Substrates
Authors: Sun Kai , Wheeler Callum , Hillier James A. , Ye Sheng , Zeimpekis Ioannis , Urbani Alessandro , Kalfagiannis Nikolaos , Muskens Otto L. , de Groot Cornelis H. (Kees) 
Published: September 2022

AbstractThe unique structural transition of VO2 between dielectric and metallic phases has significant potential in optical and electrical applications ranging from volatile switches and neuromorphic computing to smart devices for thermochromic control and radiative cooling. Critical condition for their widespread implementation is scalable deposition method and reduction of the phase transition to near room temperature. Here, a W:VO2 process based on atomic layer deposition (ALD) is presented that enables precise control of W‐doping at the few percent level, resulting in a viable controllable process with sufficient W incorporation into VO2 to reduce the phase transition to room temperature. It is demonstrated that the incorporation of 1.63 at.% W through ALD growth leads to a state‐of‐the‐art phase transition at 32 °C with emissivity contrast between the low‐temperature and high‐temperature phase exceeding 40% in a metasurface‐based radiative cooling device configuration. The process is shown to be viable on 200 mm silicon substrates as well as flexible polyimide films. The full and self‐consistent temperature‐dependent characterization of the W‐doped VO2 using spectroscopic ellipsometry, electrical conductivity, mid‐wave infrared camera, and Fourier transform infrared emissivity, allows for a fully validated material model for the theoretical design of various smart and switchable device applications.
Enhanced Targeting, Retention, and Penetration of Amphotericin B Through a Biomimetic Strategy to Treat Against Vulvovaginal Candidiasis
Authors: Lin Yijing , Yin Qingqing , Zhuge Deli , Hu Yiqin , Yang Xuewei , Tian Dongyan , Li Li , Wang Haonan , Liu Shuangshuang , Weng Cuiye , Zhang Xufei , Wen Bin , Wang Fang , Yan Linzhi , Chen Mengchun , Wang Ledan , Chen Yijie 
Published: September 2022

AbstractAn effective therapeutic strategy to treat vulvovaginal candidiasis (VVC) that is mainly caused by Candida albicans (C. albicans) infection is highly desirable. While Amphotericin B (AmB) has demonstrated promise, its precise localization to C. albicans burden at vaginal sites is oftentimes limited by the high fluidity microenvironment of the vagina, which can compromise treatment efficacy. To overcome this issue, a biomimetic AmB delivery system is developed, in which AmB preloaded polymeric cores are cloaked with vaginal epithelial cells membrane (VM‐ANP). With its cell membrane coating, VM‐ANP naturally targets and strongly binds with C. albicans, thus resisting the self‐cleaning of vaginal fluid. Besides its long retention property, VM‐ANP could penetrate deeply in vaginal tissue to achieve its full antifungal potential by attaching to hidden C. albicans. It is shown that both C. albicans suspension and biofilm biomass could be effectively inhibited by the VM‐ANP in vitro. In a C. albicans intravaginal infection model, treatment with VM‐ANP results in significantly decreased fungal challenges both in vaginal tissue and fluid. Overall, such biomimetic strategy adds the merit of natural cell membrane into the targeted delivery of drug in treating VVC, which also serves as a promising platform against vaginitis‐related pathogens.
US domestic workers' willingness to accept agricultural field jobs
Authors: Luckstead Jeff , Nayga Rodolfo M. , Snell Heather A. 
Published: September 2022

AbstractWorker scarcity in US agricultural field jobs has occurred often, particularly before COVID‐19. Because US domestic workers typically forgo field jobs, their participation could potentially alleviate the scarcity. We implement an attribute‐based discrete choice experiment administered before and during COVID‐19 to evaluate US domestic workers' willingness to accept field jobs and valuation for non‐pecuniary benefits. Domestic workers' average pre‐pandemic reservation wage rate of $23.57 per hour was 68% larger than the 2019 national average field‐worker wage of $13.99. Non‐pecuniary benefits (insurance, housing, food allowance, and transportation) lower their reservation wage. Respondents' willingness to accept agricultural field work increased during the COVID‐19 pandemic.
Implications of RAS mutational status in subsets of patients with newly diagnosed acute myeloid leukemia across therapy subtypes
Authors: Rivera Daniel , Kim Kunhwa , Kanagal‐Shamanna Rashmi , Borthakur Gautam , Montalban‐Bravo Guillermo , Daver Naval , Dinardo Courtney , Short Nicholas J. , Yilmaz Musa , Pemmaraju Naveen , Takahashi Koichi , Jabbour Elias J. , Pierce Sherry , Konopleva Marina , Bhalla Kapil , Garcia‐Manero Guillermo , Ravandi Farhad , Kantarjian Hagop , Kadia Tapan M. 
Published: September 2022

AbstractActivating mutations in RAS have been reported in about 10–15% of patients with AML; previous studies have not identified a prognostic significance. However, RAS mutations have emerged as a potential resistance mechanism to treatment with inhibitors of FLT3, IDH, and BCL2. We aimed to determine the characteristics and outcomes of patients with RAS‐mutated (RAS‐mut) AML across therapy subsets of 1410 patients newly diagnosed (ND AML). RAS‐mut was observed in 273 (20%) patients. Overall, patients with RAS‐mut AML had an estimated 3‐year survival rate of 38% vs. 28% in those with RAS wild type (RAS‐wt), p = .01. Among patients with RAS‐mut, favorable karyotype and concomitant NPM1 mutations were associated with a higher CR/CRi rate, OR 23.2 (95% CI: 2.7–192.7; p < .001) and OR 2.8 (95% CI: 1.1–6.9; p = .02), respectively, while secondary and treated secondary (ts)‐AML were associated with low response rates, OR 0.34 (95% CI: 0.1–0.9; p = .04) and OR 0.22 (95% CI: 0.09–0.5; p = .001), respectively. Intensive chemotherapy was associated with high response rates OR 5.9 (95% CI: 2.9–12.2; p < .001). Better median OS was observed among those with favorable karyotype, HR 0.28 (95% CI: 0.1–0.6; p = .002), and those treated with intensive chemotherapy, HR 0.42 (95% CI: 0.2–0.6 p < .001). Conversely, ts‐ AML and co‐occurrence of mutations in TP53 were associated with poor median OS; HR 2.3 (95% CI: 1.4–3.9; p = .001) and HR 1.7 (95% CI: 0.9–3.1; p = .06), respectively. The addition of venetoclax was associated with a non‐significant improvement in CR/CRi and OS.
Direct CO2 Transformation to Aliphatic Polycarbonates
Authors: Tamura Masazumi , Nakagawa Yoshinao , Tomishige Keiichi 
Published: September 2022

AbstractReduction of CO2 emission is an important issue all over the world, and the development of effective transformation methods of CO2 into valuable chemicals is highly desirable. Among various potential products derived from CO2, polymers are one of the promising target chemicals in terms of the production amount and CO2 fixation to solid materials. Therefore, the direct synthesis of polycarbonates from CO2 has recently attracted much attention because polycarbonates including polycarbonate diols are useful engineering plastics and intermediates for polyurethanes. There are many reports on the synthesis of polycarbonates from CO2 and cyclic ethers such as epoxides and oxetanes, however, the reports on the synthesis from CO2 and diols are limited. In this review, we summarize the recent progress of direct polycarbonate synthesis from CO2 and diols and explain the potential and issues for industrialization based on the characteristics of the reaction systems.