bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical effect and prognostic factors of mechanical thrombectomy in the treatment of acute ischemic stroke
Authors: Li Liang , Cheng Peipei , Zhang Jiwei , Wang Guang , Hu Tiemin , Sun Fan 
Published: April 2022

Objectives: To explore the clinical effect and prognostic factors of mechanical thrombectomy in the treatment of acute ischemic stroke.
Methods: The records of patients with acute ischemic stroke treated in our hospital from April 2020 to April 2021 were retrospectively selected. A total of 65 patients were treated with mechanical thrombectomy. After treatment, they were scored with modified Rankin Scale (MRS). The treatment effect and prognostic factors were analyzed.
Results: The occluded vessels were successfully opened in 65 patients. The recanalization rate was 96.92%. There were no serious complications of thrombectomy. The time from femoral artery puncture to vascular recanalization was (84.06±16.64) minutes and the number of thrombectomies was (2.52±0.71). There were 42 patients with good prognosis and 23 patients with poor prognosis. Analysis of the prognostic factors showed that the time from onset to admission in the good prognosis group was shorter, the NIHSS score before thrombectomy was higher, and the Alberta stroke program early CT Score (ASPECT) score was lower as compared to the patients in the poor prognosis group. The grade of vascular recanalization in the good prognosis group was better than that in the poor prognosis group, and the level of PCT was lower (P<0.05). Logistic regression analysis showed that the time from onset to admission, NIHSS and ASPECT scores before thrombectomy were the prognostic factors of mechanical thrombectomy in the treatment of acute ischemic stroke.
Conclusion: Mechanical thrombectomy is effective in the treatment of acute ischemic stroke and can effectively promote the recanalization of occluded vessels, but the NIHSS and ASPECT scores from the onset to the time of admission before thrombectomy can directly affect the prognosis of patients.
doi: https://doi.org/10.12669/pjms.38.5.5723
How to cite this:Li L, Cheng P, Zhang J, Wang G, Hu T, Sun F. Clinical effect and prognostic factors of mechanical thrombectomy in the treatment of acute ischemic stroke. Pak J Med Sci. 2022;38(5):---------. doi: https://doi.org/10.12669/pjms.38.5.5723
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Patient perspectives on elective orthopaedic surgery during the COVID-19 pandemic: a comparison between patients from different ethnic backgrounds
Authors: Hodgson H , Golmohamad R , Gulati A , Pandit H , Palan J , Giannoudis P , Howard A 
Published: April 2022

Introduction Suspending elective surgery during the first wave of coronavirus (COVID-19) led to record-breaking numbers of patients on waiting lists. Patients in Black, Asian and minority ethnic (BAME) groups are disproportionately affected by COVID-19. This study compares the perspectives of patients from different ethnic backgrounds on the return to elective surgery. Methods Some 151 patients were sampled from cancelled operating lists at two hospitals. Semi-structured interviews focused on the impact of COVID-19, and views about resuming elective surgery. The Generalized Anxiety Disorder 7-iten Scale (GAD-7) measured anxiety. A visual analogue scale (VAS) measured pain. Data were analysed using exploratory thematic analysis. Results Fewer BAME patients were pleased about restarting surgery, compared with white patients (47.3% vs 82.6%, p<0.001), and a greater proportion wanted to postpone their operation until after the pandemic (21.8% vs 9.3%, p=0.048). White/white British patients had higher GAD-7 scores (2 (0–21) vs 0 (0–16), p=0.009). Black/Black British patients had significantly higher VAS scores compared with white/white British and Asian/Asian British patients (85 vs 75 vs 70 respectively, p<0.05). Conclusion The delay in surgery due to the pandemic has had a devastating impact on patients awaiting operations. The variation in pain and anxiety levels between ethnic groups must be addressed when redesigning services to avoid discrepancies in postoperative clinical outcomes. Patients in BAME groups are more likely to postpone their operation, which may lead to further health deterioration, psychosocial and socio-economic consequences, and poorer clinical outcomes following surgery. The thoughts, feelings and concerns of all must be considered when redesigning services to prevent health inequalities between patients from different backgrounds.
Serum TSH as a predictor of malignancy in indeterminate thyroid nodules
Authors: Amado A , Castro B , Torre AP , Graça S , Tavares A , Póvoa A , Soares C , Gonçalves G 
Published: April 2022

Introduction Thyroid nodules are lesions that are radiologically distinct from the thyroid parenchyma. Cervical ultrasound diagnoses 19–67% of nodules and is crucial in identifying those that lack cytological characterisation. Approximately 25% of biopsies reveal an indeterminate cytological result (Bethesda III), in which the risk of malignancy is variable (5–15%). The clinical importance of the diagnostic strategy used for thyroid nodules results from the need to exclude malignancy. The aim of this study was to evaluate the usefulness of serum thyroid-stimulating hormone (TSH) levels as a predictor of malignancy in cytologically indeterminate thyroid nodules. Methods Our retrospective study included 40 patients with cytologically indeterminate thyroid nodules seen in our hospital between January 2013 and December 2017. Clinical parameters were reviewed, including age, gender, serum TSH levels, family history of thyroid carcinoma, radiation exposure and some sonographic features of the nodules. Statistical analysis was performed using SPSS. Statistical significance was defined as p<0.05. Results Female gender was predominant (85%) and the mean (SD) age was 53.3 (15) years. Thyroid carcinoma was confirmed in 28% of patients. Median TSH levels were higher in patients with malignant (2.73µIU/ml) compared with benign (1.56µIU/ml) nodules (p<0.05). We demonstrated an increased risk of malignancy in patients with TSH levels of 2.68µIU/ml or above (p<0.05). Conclusion Higher serum TSH levels are associated with an increased risk of thyroid carcinoma in cytologically indeterminate nodules. TSH can become a fundamental diagnostic tool in stratifying the risk of malignancy and assist in diagnostic and therapeutic approaches to these nodules.
Optimization of an integrated approach to voice correction for endocrinopathies (analytical review)
Authors: Starostina S. V. , Statsenko Ya. A. , Svistushkin V. M. 
Published: April 2022

Dysphonia is a symptom of many endocrine pathologies. Hoarseness, voice fatigue, decrease of the voice pitch, reduce of the range are typical complaints for hypothyroidism, caused by an increased amount of polysaccharides and accumulation of fluid in the lamina propria of the vocal folds. An excess of growth hormone causes an overproduction of insulin-like growth factor-1, which leads to abnormalities in the craniofacial region and proliferation of the upper respiratory tract tissues, including thickening of the laryngeal cartilages, vocal folds and decreasing of the voice pitch. Hyperglycemia, changes in the balance of fluid and electrolytes in diabetes mellitus can indirectly affect the voice: xerostomia complicates phonation due to impaired hydration of the laryngeal mucosa, diabetic neuropathy often disrupts the work of the laryngeal muscles involved in voice formation. Voice changes are observed not only in endocrine disorders, but also during puberty, the phases of the menstrual cycle and during menopause. Laryngeal structures are modified under the influence of hormones and external factors, which generally changes pitch and intensity of the voice, timbre and resonance, articulation and prosodic characteristics. The purpose of this review is to summarize and systematize data on physiological and pathological voice changes in patients of different age groups and sex. The possibilities of a multidisciplinary approach to rational voice correction are demonstrated.
Early manifestation and progressive multicomponent current of McCune–Albright-Braitsev syndrome in a girl 9 years old: a clinical case and literature review
Authors: Girsh Ya. V. , Kareva M. A. , Makazan N. V. , Davygora E. N. 
Published: April 2022

McCune–Albright–Braitsev Syndrome (MAB syndrome) is a very rare multisystem disease manifested by fibrous bone dysplasia, coffee-and-milk colored spots, hyperfunction of various endocrine glands and a number of pathologies of other body systems. We present a description of a clinical case of a severe progressive course of MAB Syndrome in a nine-year-old girl. With this diagnosis, the girl is observation of the girl began when she was 2.5 years old, when spots of coffee-and-milk, polyosseous fibrous dysplasia, peripheral premature sexual development against a backdrop of estrogen-­secreting ovarian cysts, multinodular goiter were detected. In the process of dynamic observation, it was noted that the child’s active growth stopped against a backdrop of deformities of the skeletal system with multiple repeated fractures of the extremities; progression of skull deformity with stenosis of the optic nerve canals and deterioration of visual acuity; development of STH hypersecretion, hypophosphatemic rickets, tachycardia. Appropriate suppressive / replacement therapy was prescribed for each of the endocrine dysfunctions. The article presents algorithms for examining a girl in dynamics, criteria for choosing a component-wise management tactics and a discussion of the features of the course of all manifestations of the Syndrome.
Determination of Fit to Work Status for Thyroid Cancer Survivor: A Case Study in Occupational Health Setting
Authors: Hardy Syaifoel , Tukayo Isak Jurun Hans , Fahruddin Akhir , Afzal Ridha 
Published: April 2022

Introduction: A thyroid cancer worker after undergoing ablation procedure requires specific recommendation when return to work. This study aims to determine a framework of the fitness to work (FTW) status from the occupational health nursing viewpoint. The implication is to help answer the question whether the worker is fit to work as a cancer survivor.Methods: This study used a Case Study method with descriptive design. The sample was a therapist associate whose scope of work was office-based. The method applied the Test Blueprint of case management assessment by the American Board of Occupational Health Nursing (ABOHN) standard combined with the Glasgow Coma Scale (GCS) after the ablation procedure as the instrument. We analyzed the case with The Fit to Work (FTW) Model of Hybrid Model.Results: FTW assessment showed vital signs within normal limits. Immunological examination found abnormalities. The left and right thyroid lobes were not visualized and there was no mass in the surgical bed. The client was advised for specialist follow up after 6 months. After the ablation procedure, the employee had a verbal communication disorder. The Glasgow Coma Scale (GCS) recorded point 5 hoarseness with decreased tone quantity was about 90%. Based on the medical report and his specialist’s advice, 6 months after ablation the employee’s medical condition showed improvement.Conclusion: With the At-Will Model of Hybrid as the framework to determine the fitness status, we recommended to declare him fit with restrictions and advised for regular fitness status update.
Application of exogenous auxin and gibberellin regulates the bolting of lettuce (Lactuca sativa L.)
Authors: Wang Yubo , Li Bingyan , Li Yunfeng , Du Wei , Zhang Yueting , Han Yingyan , Liu Chaojie , Fan Shuangxi , Hao Jinghong 
Published: April 2022

Abstract
Plant bolting is regulated and controlled by various internal and external factors. We aimed to provide an improved method for breeding to determine whether there is a synergism between hormones and to explore the regulatory effect of plant hormones on the bolting of leaf lettuce. Lettuce plants were sprayed with exogenous auxin and gibberellin separately or in combination. The specific bolting period was determined by the change in stem length and cytological observation. The dynamic changes in endogenous hormones and genes closely related to bolting were analyzed. Treatment with gibberellin alone and the combined application of auxin and gibberellin induced bolting on the fourth day, and treatment with auxin alone resulted in bolting on the eighth day. In the early bolting stage, the auxin contents in the stems of the treatment groups, especially the combined gibberellin and auxin group, were higher than those of the control group. After the application of exogenous auxin and gibberellin, we found that the expression of the ARF8 and GID1 genes was upregulated. Based on the results of our study, combined treatment with exogenous gibberellin and auxin was the best method to promote the bolting of leaf lettuce, and the ARF8 and GID1 genes are closely related to this process.
Analysis of genetic characteristics of 436 children with dysplasia and detailed analysis of rare karyotype
Authors: Miao Zong-Yu , Chen Shi-Feng , Wu Hong , Liu Xiao-Yan , Shao Hui-Yuan 
Published: April 2022

Abstract
Chromosomal abnormality is one of the important causes of dysplasia in children. However, due to regional and ethnic differences, the reported rates of chromosomal abnormalities in patients with dysplasia vary greatly. Moreover, the clinical manifestations in children with rare chromosomal diseases were heterogeneous. So, we retrospectively analyzed the karyotype results of 436 children with dysplasia and conducted a detailed analysis of rare chromosomal diseases. The results showed that chromosomal abnormalities were present in 181 of 436 cases. Intellectual disability, dysmorphology, congenital malformations, the disorder of sexual development, and short stature were the main five clinical symptoms in children with chromosomal abnormalities. Moreover, 136 cases of Trisomy 21 (Tri21) were detected, of which 130 were standard Tri21, 5 were robertsonian Tri21, and 1 was chimera type. In addition, 16 cases of rare abnormal karyotype, including complex Tri21, complex Turner syndrome, 4p-syndrome, 18q-syndrome, and 5p-syndrome, were also detected. In summary, chromosome abnormality is one of the important causes of dysplasia in children. Furthermore, prenatal screening and diagnosis could play a great significance in preventing dysplasia in children. In addition, the retrospective analysis of rare cases is valuable for clinical diagnosis and risk assessment of recurrence.
Reference intervals for Sysmex XN hematological parameters as assessed in the Dutch Lifelines cohort
Authors: L. van Pelt Joost , Klatte Stefanie , Hwandih Talent , Barcaru Andrei , Riphagen Ineke J. , Linssen Jo , Bakker Stephan J.L. 
Published: April 2022

Abstract

Objectives
Our aim was to derive reference intervals for all Sysmex XN hematology analyzer parameters. The rationale behind the study was the lack of reference intervals for the XN analyzer cell population data (CPD) and functional parameters.

Methods
Fresh fasting blood samples from 18,484 participants in the Dutch Lifelines study were analyzed using two automated XN analyzers. Structured health questionnaire data were used to select a subgroup of 15,803 apparently healthy individuals for inclusion in the reference population. The Latent Abnormal Values Exclusion (LAVE) approach was used to reduce the influence of latent diseases in the reference population on the resulting reference intervals. We applied analysis of variance to judge the need for partitioning of the reference intervals by sex or age.

Results
We report reference intervals for 105 XN analyzer hematological parameters with and without applying LAVE. Sex-related partitioning was required for red blood cells, (RBC, RBC-O), hemoglobin (HGB, HGB-O), hematocrit (HCT), mean corpuscular hemoglobin concentration (MCHC), reticulocyte production index (RPI), and side scattered light intensity of the red blood cell population in the RET channel (RBC-Z). Partitioning for age was not warranted. Body mass index (BMI) and smoking had moderate influence on a minority of the parameters.

Conclusions
We provide reference intervals for all Sysmex XN analyzer routine, CPD and functional parameters, using a direct approach in a large cohort in the Netherlands.
Research on data mining method of network security situation awareness based on cloud computing
Authors: Zhou Ying , Zhao Guodong , Alroobaea Roobaea , Baqasah Abdullah M. , Miglani Rajan 
Published: April 2022

Abstract
Due to the complexity and versatility of network security alarm data, a cloud-based network security data extraction method is proposed to address the inability to effectively understand the network security situation. The information properties of the situation are generated by creating a set of spatial characteristics classification of network security knowledge, which is then used to analyze and optimize the processing of hybrid network security situation information using cloud computing technology and co-filtering technology. Knowledge and information about the security situation of a hybrid network has been analyzed using cloud computing strategy. The simulation results show that a cyber security crash occurs in window 20, after which the protection index drops to window 500. The increase in the security index of 500 windows is consistent with the effectiveness of the concept of this document method, indicating that this document method can sense changes in the network security situation. Starting from the first attacked window, the defense index began to decrease. In order to simulate the added network defense, the network security events in the 295th time window were reduced in the original data, and the defense index increased significantly in the corresponding time period, which is consistent with the method perception results, which further verifies the effectiveness and reliability of this method on the network security event perception. This method provides high-precision knowledge of network security situations and improves the security and stability of cloud-based networks.
Mediale Inszenierung geteilter Autor*innenschaften: Pauline Viardot-Garcìas Rollenporträts als Orphée (Paris, Disdéri, 1859)
Authors: Fischer Christine 
Published: April 2022

AbstractThe methodology and subject matter of this essay venture into the disciplinary borderlands of musicology. Taking Disdéri’s carte-de-visite portraits of the singer Pauline Viardot-Garcìa as a starting point, it attempts to broaden the notion of of the author for a historical period that quintessentially stood for the establishment of the concept of genius and thus for a definition and limitation of authorship as individual and singular. The article combines an interdisciplinary approach by considering image and media theory, theories of art and its practices, alongside historical musicological methods. Its theoretical perspective is situated at the intersection of performativity and media theory via the concepts of the ›messenger figure‹ (Botenfigur) and the ›reading of traces‹ (Spurenlesen) both according to Krämer, thus opening up a historical resonance space for contemporary music practices. As a consequence, the re-perspectivization goes beyond the basic understanding that multiple authorships are at work in every form of sounding music. Instead, it fixes diverse facets of the term authorship on a concrete example and reframes them methodologically. Thus, as a basis for a systematic generalization in music research, a model is proposed that makes medial transitions in performatively negotiated authorships describable, categorizable, and at the same time historicizable. With these interdisciplinary concerns in mind, Viardot-Garcìa’s photographic portraits in her role as Orphée in Gluck’s opera of the same name from 1859 appear to have been instrumentalized in a multilayered representational way: as images standing for a performance, as a photographic image reminiscent of a painting, as a depiction of classical Greek costume that takes on meaning for the present, as the visual standing in for the acoustic, as a depiction of a female singer embodying a man, and finally also of a title role standing in for an opera as a whole. How exactly these relations of representation are to be grasped – both in the French Gluck opera revival and in the photographic images discussed – has not yet been explored in depth. To attempt to entangle all these meanings is not motivated by trying to identify the ›actual‹ portions of the musical adaptations made by different persons to Gluck’s opera in the course of its 1859 revivals. Rather, this new perspective on the carte-de-visite photographs is intended to outline Viardot-Garcìa’s figure with the help of the numerous functions the singer assumed in the production. The essay thus looks at a blind spot that is still dominant in music research, namely the question of the methodological framing of performative authorship in historical perspective. It questions the critical concepts of ›messenger figure‹ and of the ›reading of traces‹ not only for their suitability to grasp the basic questions of the example dealt with in the text, but also for their potential for generalization.