bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pressure-driven dynamical microfluidic pumping system for droplet production
Authors: Yu Chengzhuang , Wei Chunyang , Li Shanshan , Meng Jiyu , Dai Shijie , Li Junwei 
Published: October 2022

Abstract
Compact and affordable microfluidic pumping is critical for
point-of-care applications. Here we proposed a data driven dynamical
system to build up a pressure-driven microfluidic pump with a small
budget. Firstly, a precision flow sensor is required to obtain the
dynamic flow rates as the responses to the driven pressures. Then
the flow rate dataset under varying operation pressures is used for
data training and model-based system identification. With a
first-order or second-order transfer function model, the
specifications of pressure-driven microfluidic pumping system are
analyzed by the model-based system identification algorithm. Also,
all the specifications including the gain, time constant, natural
frequency, and damping ratio are updated online as new test data are
introduced from more experimental trials. To perform a non-bulky
design purpose, the data training system identification is taken on
a commercial smartphone. Once the training performance is satisfied,
the pressure-driven system could be operated without any flow
sensors. The system is used for two-phase flow controls as a
demonstration, showing a rapid response of pumping. Dynamic
characteristics and the effects of flow resistance on the pumping
performance are analyzed to verify its suitability for a wide range
of microfluidic applications.
Updated projections of UK heat-related mortality using policy-relevant global warming levels and socio-economic scenarios
Authors: Jenkins Katie , Kennedy-Asser Alan , Andrews Oliver , Lo Y T Eunice 
Published: October 2022

Abstract
High temperatures and heatwaves are associated with significant impacts on human health. With continued global temperature increases, extreme thresholds relevant to health will be exceeded more frequently. This study provides an updated spatial analysis of heat-related mortality for the UK, using the UK Climate Projections (UKCP18) at 1.5 °C–4 °C global warming levels, and embedding population and demographic data from the recently released UK Shared Socioeconomic Pathways (UK-SSPs). Climate change will lead to an increase in heat-related mortality in the future, exacerbated by increased exposure due to increasing population. We find an increase from ∼1400 average annual deaths in the near-past (1990–2019) (95% CI: 1299–1485), to ∼2500 (2304–2794), ∼3700 (3280–4214), ∼8200 (7376–9072) and >18 000 (16 690–20 394) average annual deaths at 1.5 °C, 2 °C, 3 °C and 4 °C respectively (assuming no adaptation). This is considered a high-end estimate due to the assumption of high population growth (UK-SSP5). Older populations are shown to be most vulnerable. A large proportion of heat-related deaths (76% (74%–79%) with 1.5 °C global warming) are attributed to more moderate (1 °C–5 °C) increases above regional temperature thresholds as opposed to extremes. Our results provide a timely update that can serve as a first step to supporting future UK climate policy and risk assessments. Future research considering nonlinearity in the health response to heat exposure is vital.
Increases in China’s wind energy production from the recovery of wind speed since 2012
Authors: Liu Yi , Zeng Zhenzhong , Xu Rongrong , Ziegler Alan D , Jerez Sonia , Chen Deliang , Azorin-Molina Cesar , Zhou Lihong , Yang Xinrong , Xu Haiwei , Li Laurent , Dong Li , Zhou Feng , Cao Renjing , Liu Junguo , Ye Bin , Kuang Xingxing , Yang Xin 
Published: October 2022

Abstract
China has realized a 56-fold increase in installed wind capacity, from 5.9 GW in 2007 to 328 GW in 2021. In addition to increasing installed capacity, plans to substantially increase wind energy production for climate change mitigation also depend on future wind speeds, which strongly influences the efficiencies of installed turbines within individual wind farms. A reversal in globally decreasing wind speeds over several decades has been reported previously. However, subsequent studies using other data sources reported only a slight increase or no reversal in China. These uncertainties regarding China’s wind energy production hamper estimates of wind energy production potential. Here, our analysis of quality-controlled wind speed measurements from in-situ stations shows that the wind speed decline in China reversed significantly since 2012 (P < 0.001), but with substantial spatio-temporal variability. We further estimated the capacity factor (CF) growth and the wind power gain solely associated with the changes in wind speed ranges from 31.6 to 56.5 TWh yr−1 based on the 2019 installed capacity. This estimate explains 22.0%–39.3% of the rapid increase in wind generation CF in China during 2012–2019. The result implies that the site selection of wind farms should consider both current wind situation and future wind speed trends. Further studies are needed to understand the driving factor of wind speed recovery in support of the wind energy industry.
Archetypes of agri-environmental potential: a multi-scale typology for spatial stratification and upscaling in Europe
Authors: Beckmann Michael , Didenko Gregor , Bullock James M , Cord Anna F , Paulus Anne , Ziv Guy , Václavík Tomáš 
Published: October 2022

Abstract
Developing spatially-targeted policies for farmland in the European Union (EU) requires synthesized, spatially-explicit knowledge of agricultural systems and their environmental conditions. Such synthesis needs to be flexible and scalable in a way that allows the generalization of European landscapes and their agricultural potential into spatial units that are informative at any given resolution and extent. In recent years, typologies of agricultural lands have been substantially improved, however, agriculturally relevant aspects have yet to be included. We here provide a spatial classification approach for identifying archetypal patterns of agri-environmental potential in Europe based on machine-learning clustering of 17 variables on bioclimatic conditions, soil characteristics and topographical parameters. We improve existing typologies by (a) including more recent biophysical data (e.g. agriculturally-important soil parameters), (b) employing a fully data-driven approach that reduces subjectivity in identifying archetypal patterns, and (c) providing a scalable approach suitable both for the entire European continent as well as smaller geographical extents. We demonstrate the utility and scalability of our typology by comparing the archetypes with independent data on cropland cover and field size at the European scale and in three regional case studies in Germany, Czechia and Spain. The resulting archetypes can be used to support spatial stratification, upscaling and designation of more spatially-targeted agricultural policies, such as those in the context of the EU’s Common Agricultural Policy post-2020.
Analytic continuation over complex landscapes
Authors: Kent-Dobias Jaron , Kurchan Jorge 
Published: October 2022

Abstract
In this paper we follow up the study of ‘complex complex landscapes’ (Kent-Dobias and Kurchan 2021 Phys. Rev. Res.
3 023064), rugged landscapes of many complex variables. Unlike real landscapes, the classification of saddles by index is trivial. Instead, the spectrum of fluctuations at stationary points determines their topological stability under analytic continuation of the theory. Topological changes, which occur at so-called Stokes points, proliferate among saddles with marginal (flat) directions and are suppressed otherwise. This gives a direct interpretation of the gap or ‘threshold’ energy—which in the real case separates saddles from minima—as the level where the spectrum of the hessian matrix of stationary points develops a gap. This leads to different consequences for the analytic continuation of real landscapes with different structures: the global minima of ‘one step replica-symmetry broken’ landscapes lie beyond a threshold, their hessians are gapped, and are locally protected from Stokes points, whereas those of ‘many step replica-symmetry broken’ have gapless hessians and Stokes points immediately proliferate. A new matrix ensemble is found, playing the role that GOE plays for real landscapes in determining the topological nature of saddles.
Haake–Lewenstein–Wilkens approach to spin-glasses revisited
Authors: Lewenstein Maciej , Cirauqui David , Ángel García-March Miguel , Guigó i Corominas Guillem , Grzybowski Przemysław , Saavedra José R M , Wilkens Martin , Wehr Jan 
Published: October 2022

Abstract
We revisit the Haake–Lewenstein–Wilkens approach to Edwards–Anderson (EA) model of Ising spin glass (SG) (Haake et al 1985 Phys. Rev. Lett.
55 2606). This approach consists in evaluation and analysis of the probability distribution of configurations of two replicas of the system, averaged over quenched disorder. This probability distribution generates squares of thermal copies of spin variables from the two copies of the systems, averaged over disorder, that is the terms that enter the standard definition of the original EA order parameter,

q

EA

. We use saddle point/steepest descent (SPSD) method to calculate the average of the Gaussian disorder in higher dimensions. This approximate result suggest that

q

EA

>
0

at

0
<
T
<

T
c

in 3D and 4D. The case of 2D seems to be a little more subtle, since in the present approach energy increase for a domain wall competes with boundary/edge effects more strongly in 2D; still our approach predicts SG order at sufficiently low temperature. We speculate, how these predictions confirm/contradict widely spread opinions that: (i) There exist only one (up to the spin flip) ground state in EA model in 2D, 3D and 4D; (ii) there is (no) SG transition in 3D and 4D (2D). This paper is dedicated to the memories of Fritz Haake and Marek Cieplak.
Embodied reclamation: how Big Baby Balam and Danza Ocelotl represent the body as a site for decolonization
Authors: Irwin Laura 
Published: October 2022

AbstractIn this article, I investigate how two paintings—Big Baby Balam and Danza Ocelotl—represent the potential for embodied reclamation for Chicanas/os. Through these paintings, the artist Yreina D. Cervántez situates her body as a site for decolonization through a process which I describe as embodied reclamation. In decolonizing her body and situating her body as a site for decolonization, Cervántez represents the body as a physical and material location that was colonized and can be reclaimed. This article extends decolonial theories to discuss embodied reclamation, which reconceptualizes the body as a physical site for reclamation rather than colonization. I am looking at the way these paintings represent a wrestling with embodied identity, and from that I call for more work exploring the “art of identity” as a strategy of self-making in contexts where particular bodies are Othered and brutalized.
A case report on recurrent area postrema syndrome in AQP4-IgG-positive NMOSD
Authors: Shrestha Ramesh , Kharel Ghanshyam 
Published: October 2022

ABSTRACTNeuromyelitis optica spectrum disorder (NMOSD) is an inflammatory condition of the central nervous system caused by severe immune-mediated demyelination and axonal destruction, mainly affecting optic nerves and the spinal cord. We describe a 26-year-old Nepalese woman with recent onset of headache, nausea, vomiting and hiccups indicative of Area Postrema Syndrome (APS). The antibody test for aquaporin-4 was strongly positive. Brain magnetic resonance imaging (MRI) showed a bilateral hyperintense signal in the area postrema (AP). The patient started on methylprednisolone, and then azathioprine was added. However, the patient was readmitted because of tingling in her right upper extremity and sudden onset of tremors. An MRI scan showed an enlarged lesion in AP. Rituximab was started on top of the previous treatment, and a second dose was given after 2 weeks. The patient had been monitored regularly and symptom-free for 5 months. Hence, we emphasize the immediate need for a diagnostic approach for NMOSD management.
Long-term effect of venetoclax therapy in a patient with the transformation of chronic lymphocytic leukemia into Richter’s syndrome
Authors: Tutaeva Victoria Vladimirovna , Ovsannikova Maria Romanovna , Bobin Alexander Nikolaevich , Kuchma Yurii Miroslavovich , Rukavitsin Oleg Anatolievich 
Published: October 2022

ABSTRACTRichter’s syndrome (RS) is the next step in the progression of chronic lymphocytic leukemia (CLL) progression. It leads to reduced overall patient survival, the necessity of aggressive chemotherapy and a decline in the quality of life. The first line of RS treatment includes traditional chemotherapy such as rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone. However, during the past decade, novel targeted agents added to the therapy dramatically changed the treatment outcome for patients with RS. In our case, we describe a patient with CLL that had progressed to RS and achieved complete remission that lasted &gt; 15 months with venetoclax monotherapy.
Two viruses in a pod: a case series of coinfection of COVID-19 with dengue
Authors: Ravindra Prithvishree , Wilson William , Macharla Aparna , Umakanth Shashikiran , Saravu Kavitha , Gupta Nitin 
Published: October 2022

ABSTRACT
In regions endemic to both COVID-19 and dengue, cases of coinfections are possible. Since they have similar clinical presentations, but management might be different, it is crucial to identify these cases of coinfections. We diagnosed seven cases of dengue–COVID-19 coinfections. Fever, myalgia, rash and thrombocytopenia were found to be the common features. All patients recovered well with supportive treatment. We report this series to highlight the possibility of rare coinfections in endemic areas and the importance of a high index of suspicion, early diagnosis and prompt management.
INDOOR RADON (222RN) MEASUREMENTS AND ESTIMATION OF ANNUAL EFFECTIVE DOSE IN MVANGAN LOCALITY, SOUTH CAMEROON
Authors: Akamba Mbembe Bertrand , Manga André , Mbida Mbembe Serge , Ele Abiama Patrice , Saidou  , Ondo Meye Philippe , Kofane Timoléon Crépin , Ben–Bolie Germain Hubert 
Published: October 2022

Abstract
The present work was aimed at measuring indoor radon activity concentrations in dwellings in Mvangan locality, South Cameroon, in order to assess the extent of measures that may be necessary for controlling public indoor radon exposure in this area. Measurements were carried out using passive solid-state nuclear track detectors (RADONAVA Inc., RadTrak2, Sweden) following ISO 11665-4 standard. Radon concentration ranged between 36 ± 20 and 150 ± 30 Bq m−3 with arithmetic and geometric means values of 64 ± 25 and 60 ± 1 Bq m−3, respectively. These mean values were greater than worldwide values presented by United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), which are, respectively, 40 and 30 Bq m−3. 96% of dwellings that have radon concentrations below the World Health Organization (WHO) reference level of 100 Bq m−3, whereas 4% of dwellings have radon concentrations higher than this level but lower than 300 Bq m−3, the International Commission on Radiological Protection (ICRP) reference level. Annual effective doses due to indoor radon ranged between 0.7 and 2.8 mSv y−1 with an arithmetic mean value of 1.2 ± 0.5 mSv y−1. These values were below the lower limit of the ICRP-recommended action level interval 3–10 mSv y−1. It has been observed that annual effective dose received by residents in cement bricks dwellings were not significantly different (P-value = 0.565) than those received by residents in mud dwellings in Mvangan locality. The mean number of persons expected to be diagnosed with or die from cancer (solid cancers and leukemia) were 162 ± 48 (61 ± 25 for males and 101 ± 41 for females) and 82 ± 24 (33 ± 13 for males and 49 ± 20 for females), respectively. The results obtained in this study prove that the populations of Mvangan locality are exposed to a relatively low potential risk of cancer incidence and mortality.
Differential Colonization of the Plant Vasculature Between Endophytic Versus Pathogenic Fusarium oxysporum Strains
Authors: Martínez-Soto Domingo , Yu Houlin , Allen Kelly S. , Ma Li-Jun 
Published: October 2022

Plant xylem colonization is the hallmark of vascular wilt diseases caused by phytopathogens within the Fusarium oxysporum species complex. Recently, xylem colonization has also been reported among endophytic F. oxysporum strains, resulting in some uncertainty. This study compares xylem colonization processes by pathogenic versus endophytic strains in Arabidopsis thaliana and Solanum lycopersicum, using Arabidopsis pathogen Fo5176, tomato pathogen Fol4287, and the endophyte Fo47, which can colonize both plant hosts. We observed that all strains were able to advance from epidermis to endodermis within 3 days postinoculation (dpi) and reached the root xylem at 4 dpi. However, this shared progression was restricted to lateral roots and the elongation zone of the primary root. Only pathogens reached the xylem above the primary-root maturation zone (PMZ). Related to the distinct colonization patterns, we also observed stronger induction of callose at the PMZ and lignin deposition at primary-lateral root junctions by the endophyte in both plants. This observation was further supported by stronger induction of Arabidopsis genes involved in callose and lignin biosynthesis during the endophytic colonization (Fo47) compared with the pathogenic interaction (Fo5176). Moreover, both pathogens encode more plant cell wall–degrading enzymes than the endophyte Fo47. Therefore, observed differences in callose and lignin deposition could be the combination of host production and the subsequent fungal degradation. In summary, this study demonstrates spatial differences between endophytic and pathogenic colonization, strongly suggesting that further investigations of molecular arm-races are needed to understand how plants differentiate friend from foe. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Dynamic Current Focusing Compared to Monopolar Stimulation in a Take-Home Trial of Cochlear Implant Users
Authors: van Groesen Nicolaas Roelof Arnoldus , Briaire Jeroen Johannes , de Jong Monique Anna Maria , Frijns Johannes Hubertus Maria 
Published: October 2022

Objectives:
This study compared the performance of a dynamic partial tripolar cochlear implant speech encoding strategy termed dynamic current focusing (DCF) to monopolar stimulation (MP) using spectro-temporal, temporal, and speech-in-noise recognition testing.

Design:
DCF is a strategy that utilizes tripolar or high partial tripolar stimulation at threshold level and increases loudness by slowly widening current spread towards most comfortable level. Thirteen cochlear implant users were fitted with DCF and a non-steered MP matched on pulse rate, pulse width, and active electrodes. Nine participants completed the single-blinded within-subject crossover trial. Repeated testing consisted of four sessions. Strategies were allocated in a DCF-MP-DCF-MP or MP-DCF-MP-DCF design. Three-week adaptation periods ended with a test session in which speech-in-noise recognition (matrix speech-in-noise sentence test), spectro-temporal ripple tests (SMRT and STRIPES) and a temporal amplitude modulation detection test were conducted. All participants recorded their subjective experiences with both strategies using the Speech, Spatial and Qualities of Hearing Scale questionnaire.

Results:
Participants’ SMRT thresholds improved 0.40 ripples per octave (p = 0.02, Bonferroni-corrected: p = 0.1) with DCF over MP at 65 dB SPL. No significant differences between the strategies were found on speech-in-noise recognition at conversational (65 dB SPL) and soft (45 dB SPL) loudness levels, temporal testing, STRIPES, or the SMRT at 45 dB SPL. After Bonferroni correction, a learning effect remained on the matrix speech-in-noise sentence test at both loudness levels (65 dB SPL: p = 0.01; 45 dB SPL: p = 0.02). There was no difference in learning effects over time between DCF and MP. Similarly, no significant differences were found in subjective experience on the Speech, Spatial and Qualities of Hearing Scale questionnaire. DCF reduced average battery life by 48% (5.1 hours) (p < 0.001) compared to MP.

Conclusions:
DCF may improve spectral resolution over MP at comfortable loudness (65 dB SPL) in cochlear implant users. However, the evidence collected in this study was weak and the significant result disappeared after Bonferroni correction. Also, not all spectral tests revealed this improvement. As expected, battery life was reduced for DCF. Although the current study is limited by its small sample size, considering previous studies, DCF does not consistently improve speech recognition in noise over MP strategies.
50% effective concentration of sevoflurane for immobility in cerebral palsy children undergoing botulinum toxin injection
Authors: Kim Kanghui , Lee Eunhee , Jung Sung Mee , Baek Jongyoon 
Published: October 2022

Background:
This prospective study aimed to determine the optimum end-tidal sevoflurane concentration required for immobility during botulinum toxin injection in spontaneously breathing children with cerebral palsy (CP).

Methods:
Twenty-three children with spastic CP, aged 3 to 12 years, with American Society of Anesthesiologists (ASA) physical status I and II, scheduled to receive botulinum toxin type A injection were enrolled in the study. After induction of deep sedation using pre-filled 8% sevoflurane in oxygen and maintenance of the predetermined end-tidal sevoflurane concentration, the botulinum toxin was injected in spontaneously breathing children. The response to the botulinum toxin injection was classified as “movement” or “no movement” by an independent investigator who was blinded to the predetermined end-tidal sevoflurane concentration and bispectral index (BIS) value. The end-tidal sevoflurane concentration was predetermined, initiating at 2.0% with 0.2% as a step size in the next patient depending on the previous patient’s response using the modified Dixon’s up-and-down method.

Results:
Of 21 children, 12 (57.1%) showed “no movement” in response to the botulinum toxin injection. By Dixon’s up-and-down method, the 50% effective end-tidal concentration (EC50) of sevoflurane for successful botulinum toxin injection was 1.76 ± 0.15% (95% CI 1.62–1.90). Based on the dose‐response curve using probit analysis, the predicted EC50 and 95% effective end-tidal concentrations (EC95) of sevoflurane without movement were 1.77% (95% CI 1.59–2.35) and 2.09% (95% CI 1.89–5.80), respectively.

Conclusion:
Botulinum toxin injection can be successfully accomplished at an end-tidal sevoflurane concentration of 1.76 ± 0.15% in 50% of spontaneously breathing children with CP aged 3–12 years.