bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stainless steel promoted the electrochemical oxidation of amines into imines
Authors: Lee Keunyoung , Choi Hyebin , An Jaun , Kwon Ki‐Young 
Published: May 2022

AbstractWe report the electrochemical oxidation of benzylamine (BA) into the imine by applying a bare stainless steel mesh (SSM) as an anode. Scanning electron microscopy (SEM) and energy‐dispersive X‐ray spectroscopy (EDX) elemental mapping analysis confirmed that there was no corrosion on the surface of SSM after an anodic electrolysis. Based on the gas chromatography (GC) analysis and electrochemical results, it was confirmed that conversion of BA with SSM was approximately 3.3 times higher than with Pt electrode. This work suggests that the anodic electrolysis with a bare SSM could be a promising route to electrochemical oxidation of BA in the absence of oxidizing agents.
The effect of anti‐alcoholic gastric ulcer before and after vinegar‐processed Yuanhu Zhitong prescription based on spectral‐effect relationship
Authors: Wang Xuejiao , Wang Song , Hou Ajiao , Yu Huan , Zhang Jiaxu , Zheng Senwang , Zhang Shihao , Lv Jiahao , Dong Jiaojiao , Yang Liu , Kuang Haixue , Jiang Hai 
Published: May 2022

AbstractThe aim of this study was to screen out the active ingredients of Yuanhu Zhitong prescription (YZP) before and after vinegar processing to play an anti‐alcoholic gastric ulcer role through spectrum‐effect relationship. First, the fingerprint of 16 batches of YZP was studied using the ultra‐high‐performance liquid chromatography‐quadrupole mass spectrometry detector analysis (UPLC‐QDA) method. Second, gastric lesion was induced by anhydrous ethanol. The degree of gastric mucosa injury was evaluated by hematoxylin and eosin staining, and the contents of malondialdehyde and tumor necrosis factor α and superoxide dismutase were detected using the enzyme‐linked immunosorbent assay kit. Sixteen batches of YZP were analyzed using the spectrum‐effect relationship method. Finally, absorption, distribution, metabolism, and excretion (ADME) was used to evaluate the bioavailability of potential compounds. The results showed that the UPLC‐QDA method could successfully establish the fingerprint of YZP. Hematoxylin and eosin staining and biochemical indicators showed that YZP had obvious anti‐alcoholic gastric ulcer action. Coptisine chloride, corydaline, berberine chloride, palmatine, imperatorin, and phellopterin were screened out using the spectrum‐effect method, and all of them possessed good bioavailability. The results of this study suggest that YZP plays an anti‐ulcer role by exerting antioxidant and anti‐inflammatory effects through six main active components.
Encouraging green product purchase: Green value and environmental knowledge as moderators of attitude and behavior relationship
Authors: Chaihanchanchai Papaporn , Anantachart Saravudh 
Published: May 2022

AbstractGreen purchase behavior is evolving and is of growing interest to academic and business circles. To encourage the adoption of green products, it is important to identify moderators that can enhance the consistency between attitude and behavior in the consumption of green products. Within this scope, the moderating effect of psychological factors, that is, green value and environmental knowledge on the link between green purchase attitude and behavior, is investigated. More specifically, this study proposed that green value and environmental knowledge simultaneously moderated the effect of attitude on behavior in relation to green purchase. A data set of 447 samples in Thailand collected through a personal survey method was analyzed. The results from Hayes' PROCESS technique shows that attitude toward green purchase is a weak predictor of green purchasing behavior. However, with low degree of green value and high degree environmental knowledge, green purchase attitude elicited the strongest effect on behavior.
Long‐term daily oral administration of intestinal permeation enhancers is safe and effective in mice
Authors: Fein Katherine C. , Gleeson John P. , Cochran Kyle , Lamson Nicholas G. , Doerfler Rose , Melamed Jilian R. , Whitehead Kathryn A. 
Published: May 2022

AbstractAlthough protein drugs are powerful biologic therapeutics, they cannot be delivered orally because their large size and hydrophilicity limit their absorption across the intestinal epithelium. One potential solution is the incorporation of permeation enhancers into oral protein formulations; however, few have advanced clinically due to toxicity concerns surrounding chronic use. To better understand these concerns, we conducted a 30‐day longitudinal study of daily oral permeation enhancer use in mice and resultant effects on intestinal health. Specifically, we investigated three permeation enhancers: sodium caprate (C10), an industry standard, as well as 1‐phenylpiperazine (PPZ) and sodium deoxycholate (SDC). Over 30 days of treatment, all mice gained weight, and none required removal from the study due to poor health. Furthermore, intestinal permeability did not increase following chronic use. We also quantified the gene expression of four tight junction proteins (claudin 2, claudin 3, ZO‐1, and JAM‐A). Significant differences in gene expression between untreated and permeation enhancer‐treated mice were found, but these varied between treatment groups, with most differences resolving after a 1‐week washout period. Immunofluorescence microscopy revealed no observable differences in protein localization or villus architecture between treated and untreated mice. Overall, PPZ and SDC performed comparably to C10, one of the most clinically advanced enhancers, and results suggest that the chronic use of some permeation enhancers may be therapeutically viable from a safety standpoint.
Extramedullary plasmacytoma: Tumor occurrence and therapeutic concepts—A follow‐up
Authors: Holler Adrian , Cicha Iwona , Eckstein Markus , Haderlein Marlen , Pöttler Marina , Rappl Anja , Iro Heinrich , Alexiou Christoph 
Published: May 2022

AbstractBackgroundExtramedullary plasmacytoma (EMP) is a solitary tumor consisting of neoplastic plasma cells, with very little to no bone marrow involvement. EMPs are usually located in the head and neck region, but can also occur along the digestive tract, in lungs, or extremities.MethodsFollowing our publication on EMP, which appeared in 1999 (Cancer 85:2305–14), we conducted a literature search for EMP‐related reports published between 1999 and 2021. The documented cases, as well as 14 of our own patients from the ENT Clinic Erlangen, were extensively analyzed.ResultsBetween 1998 and 2021, 1134 patients with EMP were reported, for whom information about the tumor localization was available. Among those, 62.4% had EMP in the head and neck area and 37.6% in other body regions. Data on therapy were reported in 897 patients, including 34.3% who received radiation, 28.1% surgery, 22.6% a combination of surgery and radiation, and 15.9% another therapy. In 76.9% patients no recurrence or transformation to multiple myeloma (MM) was reported, 12.8% showed local recurrence and 10.2% developed MM. Radiotherapy alone was associated with a tendency for increased occurrence of MM. In patients with EMP of head and neck area, combination therapy (surgery and radiation) resulted in a 5‐year overall survival rate of 98.3%, surgery alone of 92.4%, and radiotherapy of 92.7%.ConclusionsCollectively, our analyses indicate that surgical resection alone can achieve long‐term tumor control in patients with EMP, if the tumor can be removed within safe limits without causing serious functional impairment. However, if this is not certain, either radiation or a combination of surgery and radiation therapy is suggested as an effective means of local tumor control.
The use of platelet‐rich fibrin in vestibuloplasty: A 36‐month follow‐up technique report
Authors: Salgado‐Peralvo Angel‐Orión , Uribarri Andrea , Kewalramani Naresh , Peña‐Cardelles Juan‐Francisco , Liñares Antonio 
Published: May 2022

AbstractIntroductionVestibuloplasty is a mucogingival procedure that aims to increase the vestibule and the amount of keratinized tissue (KT) around teeth and dental implants. Currently, the gold standard in this procedure is still represented by free gingival grafts (FGGs); however, they require a second surgical site, which means more morbidity for the patient and a higher risk of surgical complications, as well as surgical time and chromatic alteration of the recipient area.Case PresentationThis is a description of the vestibuloplasty technique with platelet‐rich fibrin (PRF) in a 35‐year‐old female patient with a thin gingival phenotype and no medical history of interest. The reason for consultation was tooth sensitivity during brushing and the presence of recessions in the fifth sextant.ConclusionsThe use of PRF as a graft biomaterial in vestibuloplasty is a valid and effective option as an alternative to secondary epithelialization of the surgical site, as well as to FGGs, with acceptable results in terms of KT gain and root coverage, and with minimal postoperative discomfort.Key pointsWhy is this case new information?

The use of PRF is an interesting option as an alternative to second‐intention healing, as FGGs in vestibuloplasty.
What are the keys to successful management of this case?

The most important part of the membranes is the part that was in close relation to the erythrocyte fraction in the blood collection tube, so this part must be oriented toward the recipient bed.
A minimum of four membranes should be obtained, overlapping one on top of the other.
What are the primary limitations to success in this case?

The stability of the PRF.
Deubiquitinating enzyme JOSD2 promotes hepatocellular carcinoma progression through interacting with and inhibiting CTNNB1 degradation
Authors: Huang Yao , Zeng Jianxing , Liu Teng , Xu Qingyi , Song Xianglin , Zeng Jinhua 
Published: May 2022

AbstractAlthough a variety of molecular targets have been identified, hepatocellular carcinoma (HCC) remains among the leading causes of death. As functions of they deubiquitinating enzyme Josephin domain containing 2 (JOSD2) in cancers are still poorly understood, we investigated its function and molecular mechanism in the regulation of HCC progression. Here, we indicated that JOSD2 expression is elevated in patient samples with HCC and positively associated with poor prognosis. Moreover, the promoting roles of JOSD2 in HCC cell survival, migration, and invasion were determined using in vitro models. Importantly, a mechanistic study revealed that JOSD2 binds to and decreases the ubiquitination level of catenin beta 1 (CTNNB1), a key component of Wnt signaling, thereby augmenting Wnt pathway transduction. Furthermore, a series of rescue experiments confirmed the significance of CTNNB1 in the modulation of HCC progression by JOSD2. Our study uncovered JOSD2 as a novel prognostic marker for patients with HCC and identified CTNNB1 as a pivotal partner and downstream target protein of JOSD2, which may aid in the development of JOSD2 as a promising molecular target for HCC treatment.
Mitral annular calcification—A marker of risk, and a harbinger of technical challenges during intervention
Authors: Postalian Alexander , Krajcer Zvonimir 
Published: May 2022

Key Points
Mitral annular calcification (MAC) is a marker of high cardiovascular risk, as well as an obstacle to procedural success during mitral valve surgery. This pathology leads to low intervention rates, even in symptomatic patients.
The authors find that, in carefully selected patients with MAC, mitral valve surgery can produce adequate results and should be pursued when indicated.
The procedural results and clinical benefits of transcatheter edge‐to‐edge mitral valve repair (TMVr) in this cohort of patients treated between 2015 and 2016 were less than satisfactory, and no better than those of medical therapy.
Further TMVr technical refinements are necessary before this technique can benefit patients with mitral valve dysfunction
Dohsa‐hou for unexplained regression in Down syndrome in a 19‐year‐old man: A case report
Authors: Fujino Haruo , Moritsugu Aoi 
Published: May 2022

AbstractUnexplained regression in Down syndrome (URDS) has become a significant issue in clinical practice and research. This report illustrates the case of a patient with URDS treated with psychological treatment using Dohsa‐hou, in addition to medication. Although psychological treatment may be helpful, monitoring potential risks of acute aggression is necessary.
Complex chromosomal rearrangement involving 15q11‐q13 interstitial triplication and duplication: A new case report of dysmorphic and neuropsychiatric features
Authors: Chilakamarri Lekha , Mellin‐Sanchez Estrella Lizbeth 
Published: May 2022

AbstractOur patient is the first to encompass the full spectrum of reported features related to tetrasomy of the Prader–Willi Angelman Critical Region. She has a complex chromosomal rearrangement including an interstitial triplication reported in twelve cases till date and a rare interstitial duplication reported in only four cases till date.
Isthmocele—a neglected cause of secondary infertility and implantation failure: A case report
Authors: Hosseini Elham , Aghajanpour Samaneh , Zameni Nadia , Hafezi Maryam 
Published: May 2022

AbstractIsthmocele is myometrial scar tissue that develops after cesarean section delivery. In this case, other more prevalent pathologies delayed isthmocele diagnosis as the main cause of the patient's symptoms. Considering isthmocele is a fluid‐filled pouch‐like defect associated with infection caused by stagnant menstrual blood, its immunological aspects lead to implantation failure.
Appendico‐ileal knotting causing small bowel obstruction: A case report
Authors: Abule Tewodros , Chebo Tsegaye , Billoro Bruke Berhanu 
Published: May 2022

AbstractSmall bowel obstruction (SBO) is a common cause of emergency admission to surgical ward. The etiologies for the majority of these cases include postoperative adhesions and hernia. However, acute appendicitis presenting with SBO due to appendico‐ileal knotting is a very rare and unsuspected condition in an emergency scenarios. We report a case of acute SBO in a 30‐year‐old female patient who was explored, and found to have appendico‐ileal knotting causing SBO.
PROTOCOL: Intergenerational interventions and their effect on social and mental wellbeing of both children and older people—A mapping review and evidence and gap map
Authors: Thompson‐Coon Joanna , Campbell Fiona , Sutton Anthea , Whear Rebecca , Rogers Morwenna , Barlow Jane , Carter Ellie Robinson , Sharpe Richard , Cohen Stuart , Wolstenholme Louise 
Published: May 2022

AbstractThis is the protocol for a Campbell systematic review and evidence and gap map. The objectives are as follows: identify, appraise and bring together the evidence on the use of intergenerational practice.
Real‐time sentiment analysis of students based on mini‐Xception architecture for wisdom classroom
Authors: Tian Xingyu , Tang Shengnan , Zhu Huihui , Xia Daoxun 
Published: May 2022

AbstractSentiment analysis has a wide application prospect in business, medicine, security and other fields, which provides a new perspective for the development of education. Students' sentiment data play an important role in the evaluation of teachers' teaching quality and students' learning effect, and provide a basis for the implementation of effective learning intervention. However, most of the research is to obtain the real‐time learning status of students in the classroom through teachers' naked eye observation and students' text feedback, which will lead to some problems such as incomplete feedback content and delayed feedback analysis. Based on the mini‐Xception framework, this article implements the real‐time identification and analysis of student sentiment in classroom teaching, and the degree of student engagement is analyzed according to the teaching events triggered by teacher to provide reasonable suggestions for subsequent teaching progress. The experimental results show that the mini‐Xception model trained by FER2013 data sets has high recognition accuracy for the real‐time detection of seven student sentiments, and the average accuracy is 76.71%. Compared with text feedback, it can assist teachers in understanding student learning states in time so that they can take corresponding actions, and realize the real‐time performance of wisdom classroom teaching information feedback, the high efficiency of information transmission, and the intelligence of information processing.
Clinical features and predictive biomarkers for bladder cancer in patients with type 2 diabetes presenting with haematuria
Authors: Tonry Claire L. , Evans Raymond M. , Ruddock Mark W. , Duggan Brian , McCloskey Oonagh , Maxwell Alexander P. , O’Rourke Declan , Boyd Ruth E. , Watt Joanne , Reid Cherith N. , Curry David J. , Stevenson Michael , Young Margaret K. , Jamison Catherine S. , Gallagher Joe , Fitzgerald Stephen P. , Lamont John , Watson Chris J. 
Published: May 2022

AbstractAimsTo identify clinical features and protein biomarkers associated with bladder cancer (BC) in individuals with type 2 diabetes mellitus presenting with haematuria.Materials and MethodsData collected from the Haematuria Biomarker (HaBio) study was used in this analysis. A matched sub‐cohort of patients with type 2 diabetes and patients without diabetes was created based on age, sex, and BC diagnosis, using approximately a 1:2 fixed ratio. Randox Biochip Array Technology and ELISA were applied for measurement of 66 candidate serum and urine protein biomarkers. Hazard ratios and 95% confidence intervals were estimated by chi‐squared and Wilcoxon rank sum test for clinical features and candidate protein biomarkers. Diagnostic protein biomarker models were identified using Lasso‐based binominal regression analysis.ResultsThere was no difference in BC grade, stage, and severity between individuals with type 2 diabetes and matched controls. Incidence of chronic kidney disease (CKD) was significantly higher in patients with type 2 diabetes (p = 0.008), and CKD was significantly associated with BC in patients with type 2 diabetes (p = 0.032). A biomarker model, incorporating two serum (monocyte chemoattractant protein 1 and vascular endothelial growth factor) and three urine (interleukin 6, cytokeratin 18, and cytokeratin 8) proteins, predicted incidence of BC with an Area Under the Curve (AUC) of 0.84 in individuals with type 2 diabetes. In people without diabetes, the AUC was 0.66.ConclusionsWe demonstrate the potential clinical utility of a biomarker panel, which includes proteins related to BC pathogenesis and type 2 diabetes, for monitoring risk of BC in patients with type 2 diabetes. Earlier urology referral of patients with type 2 diabetes will improve outcomes for these patients.TRIAL REGISTRATION: http://www.isrctn.com/ISRCTN25823942.
Head‐to‐head comparison between recommendations by the ESC and ACC/AHA/HFSA heart failure guidelines
Authors: Bayés‐Genís Antoni , Aimo Alberto , Metra Marco , Anker Stefan , Seferovic Petar , Rapezzi Claudio , Castiglione Vincenzo , Núñez Julio , Emdin Michele , Rosano Giuseppe , Coats Andrew J.S. 
Published: May 2022

AbstractRecommendations represent the core messages of guidelines, and are particularly important when the body of scientific evidence is rapidly growing, as in the case of heart failure (HF). The main messages from two latest major HF guidelines, endorsed by the European Society of Cardiology (ESC) and the American College of Cardiology/American Heart Association/Heart Failure Society of America (ACC/AHA/HFSA), are partially overlapping, starting from the four pillars of treatment for HF with reduced ejection fraction. Some notable differences exist, in part related to the timing of recent publications (most notably, the Universal Definition of HF paper and the EMPEROR‐Preserved trial), and in part reflecting differing views of the natural history of HF (with a clear differentiation between stages A and B HF in the ACC/AHA/HFSA guidelines). Different approaches are proposed to specific issues such as risk stratification and implantable cardioverter defibrillator use for primary prevention in HFrEF patients with non‐ischaemic aetiology. The ACC/AHA/HFSA guidelines put a greater emphasis on some issues that are particularly relevant to the US setting, such as the cost‐effectiveness of therapies and the impact of health disparities on HF care. A comparison between guideline recommendations may give readers a deeper understanding of the ESC and ACC/AHA/HFSA guidelines, and help them apply sensible approaches to their own practice, wherever that may be in the world. A comparison may possibly also help further harmonization of recommendations between future guidelines, by identifying why some areas have led to conflicting recommendation, even when ostensibly reviewing the same published evidence.
Numerical investigation of microchannel geometry for effective on‐chip biofluid delivery by AC electrothermal effect
Authors: Yuan Quan , Huang Jiamei , Wu Jie Jayne , Islam Nazmul 
Published: May 2022

AbstractAlthough there exist tremendous needs for on‐chip biofluid delivery, research in this field has yielded limited numbers of devices for real‐world applications. One challenge is the difficulty for micropumps to meet the requirements of being low cost to fabricate, easy to integrate and effective for intended applications at the same time. This research focuses on AC electrothermal (ACET) micropumps based on planar interdigitated electrodes, due to their practicality in fabrication and operation, and compatibility with biochemical fluids. Our prior work has optimized the design of electrode dimensions for a fixed microchannel design. This work finds that microchannel dimensions can also affect ACET micropumps significantly, with respect to flow rate and electric impedance loading. This work first considers the constraints arising from impedance loading by ACET micropumps on power supplies, then the investigation describes several key parameters (threshold height, saturation thickness), to arrive at an appropriate microchannel geometry for the effective delivery of biofluids. The optimized microchannel is expected to incorporate well into a multifunctional lab‐chip system to transport biofluids efficiently.
A voltage trade study for the design of capillary electrophoresis instruments for spaceflight
Authors: Ferreira Santos Mauro S. , Kurfman Emily , Zamuruyev Konstantin , Noell Aaron C. , Mora Maria F. , Willis Peter A. 
Published: May 2022

AbstractCapillary electrophoresis (CE) systems have undergone extensive development for spaceflight applications. A flight‐compatible high voltage power supply and the necessary voltage isolation for other energized components can be large contributors to both the volume and mass of a CE system, especially if typical high voltage levels of 25–30 kV are used. Here, we took advantage of our custom CE hardware to perform a trade study for simultaneous optimization of capillary length, high voltage level, and separation time, without sacrificing method performance. A capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C4D) method recently developed by our group to target inorganic cations and amino acids relevant to astrobiology was used as a test case. The results indicate that a 50 cm long capillary with 15 kV applied voltage (half of that used in the original method) can be used to achieve measurement goals while minimizing instrument size.