bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chikungunya Death Risk Factors in Brazil, in 2017: A case-control study
Authors: de Morais Alves Barbosa Oliveira Rhaquel , Kalline de Almeida Barreto Francisca , Praça Pinto Geovana , Timbó Queiroz Isabella , Montenegro de Carvalho Araújo Fernanda , Wanderley Lopes Kilma , Lúcia Sousa do Vale Regina , Rocha Queiroz Lemos Daniele , Washington Cavalcante John , Machado Siqueira André , Carla Vinhal Frutuoso Lívia , Carmen Duarte Elisabeth , Silva Lima Neto Antônio , Ricardo Ribas Freitas André , Pamplona de Góes Cavalcanti Luciano 
Published: April 2022

Background
In 2016/2017 we had a major epidemic of chikungunya (CHIK) in Brazil, with many deaths. We evaluated to factors associated with deaths from CHIK that occurred in the city of Fortaleza, Brazil.

Methods
A matched case-control study was conducted (1:2), by sex, age (± 5 years) and neighborhood. Cases were CHIK deaths that occurred between January 1 and December 31, 2017, in Fortaleza, Brazil, and which were laboratory confirmed. Controls were laboratory confirmed CHIK patients occurring in the same neighborhood and in the same period, but which did not progress to death.

Results
82 cases of CHIK and 164 controls were included. Considering the clinical history, significant associations were found between other chronic heart diseases (OR 3.8; CI: 1.53–9.26) and chronic kidney disease (OR 12.77; CI: 2.75–59.4). In the multivariate analysis of the variables related to signs and symptoms, fever (OR: 19.23 CI: 1.73–213.78), abdominal pain (OR: 3; 74 CI: 1.06–13.16), apathy (OR: 11.62 CI: 2.95–45.82) and dyspnea (OR: 50.61; CI: 12.37–207.18) were identified with greater likelihood of death from CHIK. It also stood out that altered blood glucose was associated with cases with a worse prognosis (OR: 13.5; CI: 1.3–135.0). Among the laboratory findings, only lymphocytes and albumin were not associated with greater likelihood of death.

Conclusion
The factors related with deaths were chronic kidney disease and previous heart disease, presence of fever, abdominal pain, apathy, dyspnea and arthritis and laboratory findings such as leukocytosis, leukopenia, thrombocytopenia, neutropenia and lymphopenia.
Nutritional composition and antioxidant properties of the fruit of Berberis heteropoda Schrenk
Authors: Sun Jixiang , Li Qian , Li Jianguang , Liu Jing , Xu Fang 
Published: April 2022

Objective
This study assessed the major nutrients and antioxidant properties of Berberis heteropoda Schrenk fruits collected from the Nanshan Mountain area of Urumqi City, Xinjiang Uygur Autonomous Region, China.

Methods and materials
We assessed the basic nutrients, including amino acids, minerals, and fatty acids, and determined the total phenol, flavonoid, and anthocyanin contents of the extracts.

Results
The analytical results revealed the average water (75.22 g/100 g), total fat (0.506 g/100 g), total protein (2.55 g/100 g), ash (1.31 g/100 g), and carbohydrate (17.72 g/100 g) contents in fresh B. heteropoda fruit, with total phenol, flavonoid, and anthocyanin contents of B. heteropoda fruits at 68.55 mg gallic acid equivalents/g, 108.42 mg quercetin equivalents/g, and 19.83 mg cyanidin-3-glucoside equivalent/g, respectively. Additionally, UPLC-Q-TOF-MSE analysis of polyphenols in B. heteropoda fruit revealed 32 compounds.

Conclusion
B. heteropoda fruits may have potential nutraceutical value and represent a potential source of nutrition and antioxidant phytochemicals in the human diet.
Interpersonal responses to facial expressions of disgust, anger, and happiness in individuals with varying levels of social anxiety
Authors: aan het Rot Marije , Friederici Christina , Krause Sandra C. , de Jong Peter J. 
Published: April 2022

Background and objectivesFacial expression recognition has been studied extensively, including in relation to social anxiety. Nonetheless, a limited number of studies examined recognition of disgust expressions. Results suggest that disgust is perceived as more threatening than anger, and thus may invite more extreme responses. However, few studies have examined responses to facial expressions. These studies have focused on approach-avoidance responses. Our primary aim was to examine to what extent anger and disgust expressions might invite interpersonal responses in terms of quarrelsomeness-agreeableness and dominance-submissiveness. As social anxiety has been previously associated with a heightened sensitivity to anger and disgust expressions, as well as with alterations in quarrelsomeness-agreeableness and dominance-submissiveness, our secondary aim was to examine whether social anxiety would moderate these responses.MethodsParticipants were 55 women and 43 men who completed social anxiety measures, including the Brief Fear of Negative Evaluation scale, and two tasks that involved “targets” expressing anger, disgust, or happiness at 0%, 50%, or 100%. Participants first indicated how quarrelsome or agreeable and how dominant or submissive they would be towards each target, and then how much they would avoid or approach each target.ResultsWhile 100% disgust and anger expressions invited similar levels of quarrelsomeness and avoidance, 50% disgust invited more quarrelsomeness and stronger avoidance than 50% anger. While these patterns were not meaningfully moderated by social anxiety, individuals with higher BFNE scores showed a relatively strong approach of happy faces.LimitationsActual interpersonal behaviour in response to facial expressions was not assessed.ConclusionsFindings support the relevance of disgust as an interpersonal signal and suggest that, especially at mild intensity, disgust may have a stronger impact than anger on people’s quarrelsomeness and avoidance responses. Findings provided no support for the view that people with social anxiety would be particularly responsive to disgust (or anger) expressions.
Frequency of hemorrhage after tooth extraction in patients treated with a direct oral anticoagulant: A multicenter cross-sectional study
Authors: Hiroshi Iwabuchi , Natsuko Sawai Y. , Yutaka Imai , Masayori Shirakawa , Hiroyuki Nakao , Hirohisa Imai 
Published: April 2022

Objective
Few studies have compared the frequency of hemorrhages after tooth extraction between patients taking direct oral anticoagulants (DOACs) and those taking warfarin or no anticoagulants. Further, the effects of the timing of DOAC administration and tooth extraction on the frequency of post-extraction hemorrhage have not been demonstrated. Therefore, we compared the frequency of post-extraction hemorrhages in patients in these different conditions and examined the effects of the timing of DOAC administration and tooth extraction on the frequency.

Design
Prospective multicenter study

Setting
Eighty-six Japanese hospitals.

Participants
In total, 182 teeth extracted from 145 individuals (119 teeth from adult males) receiving dabigatran and 88 teeth from individuals (62 teeth from adult males) receiving rivaroxaban were included.

Intervention
Tooth extraction was followed by a 7-day observational period between November 1, 2008 and December 31, 2015. Dabigatran was administered twice daily; rivaroxaban was administered once a day.

Primary outcome measure
Hemorrhage after tooth extraction.

Results
The frequency of hemorrhage after tooth extraction was 1.65%, 3.41%, and 3.63% in those treated with dabigatran, rivaroxaban, and warfarin, respectively, and 0.39% in those who did not receive anticoagulants. Hemorrhages after tooth extraction were significantly higher in the rivaroxaban group than in patients who did not receive anticoagulants (P = 0.008). These frequencies did not differ significantly in the dabigatran and rivaroxaban groups compared to the warfarin group (P = 0.221 and P = 1.000, respectively).

Conclusions
The frequency of hemorrhaging after tooth extraction appeared to be similar in patients receiving continuous dabigatran or rivaroxaban and in those receiving continuous warfarin.
Chronic kidney disease and atrial fibrillation: A dangerous combination
Authors: Ocak Gurbey , Khairoun Meriem , Khairoun Othman , Bos Willem Jan W. , Fu Edouard L. , Cramer Maarten J. , Westerink Jan , Verhaar Marianne C. , Visseren Frank L. ,   UCC-SMART study group
Published: April 2022

Background
Chronic kidney disease (CKD) and atrial fibrillation (AF) are both risk factors for bleeding, stroke and mortality. The aim of our study was to investigate the interaction between CKD and atrial fibrillation and outcomes.

Methods
We included 12,394 subjects referred to the University Medical Center Utrecht (the Netherlands) from September 1996 to February 2018 for an out-patient visit (Utrecht Cardiovascular Cohort Second Manifestation of Arterial disease cohort). Hazard ratios (HRs) with 95% confidence intervals (CIs) for bleeding, ischemic stroke or mortality were calculated with Cox proportional hazard analyses. Presence of interaction between AF and CKD was examined by calculating the relative excess risk due to interaction (RERI), the attributable proportion (AP) due to interaction and the synergy index (S).

Results
Of the 12,394 patients, 699 patients had AF, 2,752 patients had CKD and 325 patients had both AF and CKD. Patients with both CKD and AF had a 3.0-fold (95% CI 2.0–4.4) increased risk for bleeding, a 4.2-fold (95% CI 3.0–6.0) increased ischemic stroke risk and a 2.2-fold (95% CI 1.9–2.6) increased mortality risk after adjustment as compared with subjects without atrial fibrillation and CKD. We did not find interaction between AF and CKD for bleeding and mortality. However, we found interaction between AF and CKD for ischemic stroke risk (RERI 1.88 (95% CI 0.31–3.46), AP 0.45 (95% CI 0.17–0.72) and S 2.40 (95% CI 1.08–5.32)).

Conclusion
AF and CKD are both associated with bleeding, ischemic stroke and mortality. There is a positive interaction between AF and CKD for ischemic stroke risk, but not for bleeding or mortality.
Socioeconomic position and self-rated health among female and male adolescents: The role of familial determinants in explaining health inequalities. Results of the German KiGGS study
Authors: Rattay Petra , Blume Miriam , Wachtler Benjamin , Wollgast Lina , Spallek Jacob , Hoffmann Stephanie , Sander Lydia , Herr Raphael , Herke Max , Reuter Marvin , Novelli Anna , Hövener Claudia 
Published: April 2022

Objective
Although health inequalities in adolescence are well documented, the underlying mechanisms remain unclear. Few studies have examined the role of the family in explaining the association between the family’s socioeconomic position and adolescents’ self-rated health. The current study aimed to explore whether the association between socioeconomic position and self-rated health was mediated by familial determinants.

Methods
Using data from wave 2 of the”German Health Interview and Examination Survey for Children and Adolescents” (KiGGS) (1,838 female and 1,718 male 11- to 17-year-olds), linear regression analyses were conducted to decompose the total effects of income, education, occupational status, socioeconomic position index and adolescents’ subjective social status on self-rated health into direct effects and indirect effects through familial determinants (family cohesion, parental well-being, parental stress, parenting styles, parental obesity, smoking and sporting activity).

Results
A significant total effect of all socioeconomic position indicators on self-rated health was found, except for income in male adolescents. In female adolescents, more than 70% of the total effects of each socioeconomic position indicator were explained by familial mediators, whereas no significant direct effects remained. The most important mediator was parental well-being, followed by family cohesion, parental smoking and sporting activity. In male adolescents, the associations between income, parental education, the socioeconomic position index and subjective social status were also mediated by familial determinants (family cohesion, parental smoking, obesity and living in a single-mother family). However, a significant direct effect of subjective social status remained.

Conclusion
The analysis revealed how a family’s position of socioeconomic disadvantage can lead to poorer health in adolescents through different family practices. The family appears to play an important role in explaining health inequalities, particularly in female adolescents. Reducing health inequalities in adolescence requires policy interventions (macro-level), community-based strategies (meso-level) and programs to improve parenting and family functioning (micro-level).
Factors associated with cervical cancer screening among women aged 25–60 years in Lao People’s Democratic Republic
Authors: Phaiphichit Jom , Paboriboune Phimpha , Kunnavong Sengchan , Chanthavilay Phetsavanh 
Published: April 2022

Background
Despite cervical cancer being a major public health concern in the Lao People’s Democratic Republic (Lao PDR), screening coverage is very low. The reasons and factors for this are unknown. This study aimed to identify factors associated with uptake of cervical cancer screening among women aged 25–60 years.

Methods
The case-control study was conducted among women aged 25–60 years in Vientiane Capital and Luang Prabang province from March 15 to May 31, 2018. A total of 360 women were included in the study, a ratio of two controls per case. The cases were women who had undergone cervical cancer screening over the last five years. The controls were women who had never been screened or screened more than five years before, matched to the cases with residency and age (± five years). The cases were selected from central and provincial hospitals and the controls from the same community and districts where the cases resided. Conditional logistic regression was used to determine factors associated with cervical cancer screening.

Results
The mean age was 42.37±9.4 years (range: 25–60), 66.67% were women from Vientiane Capital, and 86.11% were married. The common reasons for not being screened were the absence of clinical signs and symptoms (45.28%) followed by never having heard about cervical cancer (13.33%). In the multivariable analyses, we found that having sexually transmitted infections (AOR = 3.93; 95% CI = 1.92–8.05), receiving recommendations for screening from health workers (AOR = 3.85; 95% CI = 1.90–7.78), a high score for knowledge (AOR = 7.90; 95% CI = 2.43–25.69) and attitude towards cervical cancer prevention and treatment (AOR = 2.26; 95% CI = 1.18–7.16), and having a car to travel (AOR = 2.97; 95% CI = 1.44–6.11) had a positive impact on undergoing cervical cancer screening.

Conclusion
Gynecological consultations, increased knowledge and positive attitudes result in women undergoing screening. Therefore, health education and advocacy for cervical cancer prevention should be provided to women.
Depression and unplanned secondary healthcare use in patients with multimorbidity: A systematic review
Authors: Cicek Meryem , Hayhoe Benedict , Otis Michaela , Nicholls Dasha , Majeed Azeem , Greenfield Geva 
Published: April 2022

Background
Growing numbers of people with multimorbidity have a co-occurring mental health condition such as depression. Co-occurring depression is associated with poor patient outcomes and increased healthcare costs including unplanned use of secondary healthcare which may be avoidable.

Aim
To summarise the current evidence on the association between depression and unplanned secondary healthcare use among patients with multimorbidity.

Methods
We conducted a systematic review by searching MEDLINE, EMBASE, PsychINFO, Web of Science, CINAHL, and Cochrane Library from January 2000 to March 2021. We included studies on adults with depression and at least one other physical long-term condition that examined risk of emergency hospital admissions as a primary outcome, alongside emergency department visits or emergency readmissions. Studies were assessed for risk of bias using The National Institute of Health National Heart, Lung, and Blood Institute quality assessment tool. Relevant data were extracted from studies and a narrative synthesis of findings produced.

Results
Twenty observational studies were included in the review. Depression was significantly associated with different outcomes of unplanned secondary healthcare use, across various comorbidities. Among the studies examining these outcomes, depression predicted emergency department visits in 7 out of 9 studies; emergency hospital admissions in 19 out of 20 studies; and emergency readmissions in 4 out of 4 studies. This effect increased with greater severity of depression. Other predictors of unplanned secondary care reported include increased age, being female, and presence of greater numbers of comorbidities.

Conclusion
Depression predicted increased risk of unplanned secondary healthcare use in individuals with multimorbidity. The literature indicates a research gap in identifying and understanding the impact of complex multimorbidity combinations, and other patient characteristics on unplanned care in patients with depression. Findings indicate the need to improve planned care for patients with moderate-to-severe depression. We suggest regular reviews of care plans, depression severity monitoring and assessment of hospital admission risk in primary care settings.
Comparative evaluation of Sodium-glucose co-transporter-2 inhibitors and dipeptidyl peptidase-4 inhibitors influence on bone turnover markers in rats with experimental type 2 diabetes mellitus
Authors: Timkina N. V. , Simanenkova A. V. , Karonova T. L. , Vlasov T. D. , Semenova N. Yu. , Bairamov А. A. , Timofeeva V. A. , Shimshilashvili A. A. , Shlyakhto E. V. 
Published: April 2022

Background: Type 2 diabetes mellitus (DM) is accompanied by increased risk of osteoporotic fractures. Data on type 2 sodium-glucose co-transporter inhibitors (SGLT-2i) in fracture risk are contradictory. A simultaneous comparison of high- and low-selective SGLT-2i effects on bone turnover parameters with the effects of other drug classes has not been performed previously.Aim: To evaluate and to compare the influence of empagliflozin (EMPA), canagliflozin (CANA) and sitagliptin (SITA) on bone remodeling parameters in type 2 diabetic rats.Materials and methods: Type 2 DM was modelled in male Wistar rats by high-fat diet and strepTozotocin+nicotinamide injection. Four weeks after the following groups were formed: “DM” without treatment, as well as 8-week treatment with SITA 50 mg/kg (“DM+SITA”), CANA 25 mg/kg (“DM+CANA”), EMPA 2 mg/kg (“DM+EMPA”). Animals in “Control” group were not subjected to any interventions. Calcium, phosphorus, fibroblast growth factor-23 (FGF23), osteocalcin (OC), osteoprotegerin (OPG), RANKL concentrations were measured in the blood sampled at the end of the treatment, as well as bone histoarchitectonics was evaluated.Results: Calcium concentration was higher in “DM+EMPA” group (2.79 (2.69; 2.83 mmol/L) comparing with “Control” (2.65 (2.53; 3.15)), phosphorus level in “DM+EMPA” was higher than in all other groups. FGF23 was decreased in “DM” group (0.24 (0.11; 0.31) pmol/L), while EMPA treatment was associated with higher FGF23 level (1.1 (0.62; 1.1). OC was lower in “DM” (10.69 (9.97; 11.03) ng/mL) than in “Control” group (49.1 (47.98; 54.57), treatment with SITA and EMPA was associated with increase in OC level (19.57 (18.85; 24.44) и 16.00 (15.72; 17.00), respectively), with OC concentration being higher in “DM+SITA” group. There were no differences in OPG and RANKL levels between “DM” and “Control” groups, whereas OPG was lower in “DM+CANA” (1.85 (1.19; 1.90) pmol/L) and “DM+EMPA” (1.26 (0.76; 1.88) than in “DM+SITA” (6.28 (3.05; 3.99). RANKL/OPG ratio was the highest in “DM+EMPA” and “DM+CANA” groups, with no significant between-group difference. In «DM+EMPA» and «DM+CANA» groups there was a decrease in the area of bone trabeculae in the epiphyseal part (56.70 (53.80; 58.05)% и 52.30 (50.50; 54.85)%) in comparison with “Control” group (62.30 (61.30; 64.20)%). All study drugs administration led to similarly satisfactory glycemic control.Conclusion: SITA influence on bone remodeling is neutral, while EMPA and CANA administration leads to increase of bone resorption. Drugs’ influence on bone metabolism is not due to their effect on glycemic profile
Review Kebijakan Penggunaan Ruang Terbuka Hijau Perkotaan antara Jakarta dengan New York pada Pandemi COVID-19
Authors: Setiowati Retno , Koestoer Raldi Hendro 
Published: April 2022

Separuh penduduk tinggal di perkotaan dan menjadi penyebab permasalahan lingkungan. Salah satunya adalah alih fungsi lahan hijau menjadi lahan terbangun. Ruang terbuka hijau memiliki fungsi ekologis, ekonomis, dan sosial yang dapat meningkatkan kualitas kehidupan perkotaan. Tujuan penelitian adalah mengkaji kebijakan penggunaan ruang terbuka hijau perkotaan pada pandemi COVID-19 menggunakan metode studi komparasi. Lokasi studi dipilih di Jakarta, Indonesia dan New York, Amerika Serikat karena kedua kota tersebut memiliki jumlah penduduk yang padat dan menjadi pelopor pertama penyebaran COVID-19 di masing-masing Negara. Responden di New York masih menggunakan ruang hijau perkotaan selama pandemi dan menganggapnya lebih penting untuk kesehatan mental dan fisik daripada sebelum pandemi dimulai. Terdapat kekhawatiran para pengunjung ruang hijau perkotaan di New York terkait jarak sosial, aksesibilitas, dan keamanan. Terjadi perubahan perilaku selama pandemi di Jakarta terhadap ruang hijau perkotaan seperti meningkatnya aktivitas pejalan kaki di sepanjang koridor hijau yang menjadi pendorong kebijakan publik dalam menanggapi perilaku dan kebutuhan baru yang muncul dari pandemi. Berdasarkan bukti empiris, perubahan perilaku di Indonesia diduga disebabkan oleh kebutuhan masyarakat untuk berekreasi dan relaksasi terhadap alam untuk mengurangi dampak psikologis yang disebabkan pembatasan sosial. Kebijakan pembukaan ruang terbuka hijau saat pandemi di Jakarta dapat dipertimbangkan dengan mengutamakan protokol kesehatan.
Pemetaan Perubahan Lahan Sawah Kabupaten Sukabumi Menggunakan Google Earth Engine
Authors: Siska Widia , Widiatmaka Widiatmaka , Setiawan Yudi , Adi Setyono Hari 
Published: April 2022

Google Earth Engine (GEE) merupakan layanan pemrosesan geospasial yang telah banyak digunakan di berbagai bidang pemetaan. Tujuan penelitian ini adalah identifikasi perubahan lahan sawah Kabupaten Sukabumi menggunakan GEE. Data citra landsat 5 dan landsat 8 yang digunakan di GEE merupakan data citra yang telah di pre-process dan terkoreksi. Klasifikasi penggunaan/tutupan lahan dibedakan menjadi 6 kelas yaitu sawah, badan air, pemukiman, bervegetasi, hutan dan tanah terbuka. Sampel acak penggunaan lahan dibuat sebanyak 394 titik di GEE menggunakan poin dan rectangular. Klasifikasi penggunaan lahan dianilisis menggunakan metode Random Forest (RF). Penilaian akurasi dihitung menggunakan confusion Matrix, sedangkan validasi lapang dilakukan dengan menggunakan metode stratified random sampling. Uji akurasi analisis tutupan lahan tahun 2020 dengan confusion Matrix menghasilkan nilai Overall Accuracy (OA) 0,94 dan nilai kappa 0,91; tahun 2015 dengan nilai OA 0,93 dan nilai Kappa 0,91; sedangkan tahun 2010 memiliki nilai OA 0.96 dan nilai Kappa 0.94. Hasil analisis ini menunjukkan bahwa luas lahan sawah Kabupaten Sukabumi mengalami penyusutan seluas 10,317.27 ha dalam kurun waktu sepuluh tahun (2010-2020). Klasifikasi penggunaan lahan menggunakan GEE dapat menghasilkan peta dengan akurasi tinggi dengan OA >85%, serta dapat mempersingkat waktu analisis.