bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Kualitas Jaringan Internet Provider Telekomunikasi Dengan Menggunakan Parameter Quality of Service (QoS) Di Kota Kendari
Authors: Setiawan Edwin , Pagiling Luther , Nur Muh Nadzirin Anshari 
Published: March 2022

Masih banyak para pelanggan yang belum mengetahui kualitas jaringan internet Provider telekomunikasi di berbagai daerah di Kota Kendari. Oleh karena itu, dilakukan penelitian ini yang bertujuan untuk mengetahui kualitas jaringan internet Provider telekomunikasi di Kota Kendari. Dalam menentukan kualitas jaringan internet di setiap Providerr menggunakan sebuah parameter yaitu parameter Quality of Service (QoS). Terdapat empat parameter Quality of Service yang dibahas adalah througputt, packet loss, delay dan jitter. Providerr telekomunikasi yang menjadi objek penelitian adalah kartu Provider telkomsel, XL dan 3 tri. Dalam menetukan kualifikasi kualitas jaringan internet menggunakan standarisasi menurut Telecommunications and Internet Protocol Harmonization Over Network (THIPON). Berdasarkan perhitungan yang telah dilakukan menghasilkan nilai througputt yang lebih baik pada Provider XL dengan nilai sebesar 1,52012 kbps. Untuk nilai packet loss menghasilkan nilai yang sama untuk ketiga Provider sebesar 0%. Nilai delay yang lebih baik terdapat pada Provider 3 tri dengan nilai sebesar 1,15259 sekon. Untuk nilai jitter yang lebih baik terdapat pada Provider 3 tri dengan nilai sebesar 1,1033 sekon. 2. Hasil perhitungan indeks nilai parameter Quality of Service (QoS) menunjukkan bahwa indeks nilai dari ketiga Provider menghasilkan indeks nilai yang sama, dengan indek nilai sebesar 3,33 dan termasuk dalam kategori bagus..
Penerapan Metode Waterfall Pada Pengendali Penerangan Ruangan Berbasis Fuzzy Logic
Authors: Yuliana Dian Efytra 
Published: March 2022

Setiap rumah memerlukan ruangan yang baik dan nyaman, salah satu aspek yang mempengaruhi kenyamanan sebuah ruangan adalah pada sistem pencahayaanya. Pada saat ini masih banyak digunakan sistem pencahayaan manual dengan prinsip on-off. Sebuah ruangan yang pencahayaannya terpengaruh oleh cahaya alam sekitar dan mempunyai system pencahayaan manual bisa mengurangi tingkat kenyamanan ruangan karena kecerahan ruangan tidak bisa diatur secara otomatis sesuai kebutuhan. Sehingga ruangan bisa menjadi terlalu terang atau terlalu redup. Hal ini dapat mengakibatkan gangguan kesehatan dan mengganggu efisiensi kerja bagi penggunanya. Oleh karena itu diperlukan sistem pencahayaan yang dapat mengkondisikan intensitas penerangan sesuai dengan kebutuhan. Alat ini bekerja berdasarkan hasil pembacaan dari LDR yang masuk ke arduino melalui port ADC. Hasil pembacaan ADC dijadikan inputan kendali fuzzy pada progam arduino. Hasil defuzzifikasi progam arduino digunakan untuk mengatur besarnya pwm yang akan diterima oleh rangkaian solid state relay. Besarnya pwm yang terima oleh rangkaian solid state relay berbanding lurus dengan tegangan yang diterima oleh lampu, sehingga besar intensitas cahaya lampu dapat diatur sesuai dengan pwm dari Arduino. LCD digunakan untuk menampilkan hasil defuzzifikasi progam. Hasil system yang di terapkan menggunakan inferensi fuzzy logic metode sugeno ordo nol dengan metode min dalam proses evaluasi aturannya mampu mempresentasikan nilai dari sebuah intensitas cahaya sekitar. Kata kunci — LDR, arduino, fuzzy logic, solid state relay, LCD.
ANALISIS KINERJA KEUANGAN DAN KEMAMPUAN KEUANGAN PEMERINTAH DAERAH DALAM PELAKSANAAN OTONOMI DAERAH DI PROVINSI SULAWESI TENGGARA
Authors: Mustarim Israwati , Rosnawintang Rosnawintang , Akib Mulyati 
Published: March 2022

This study aims to analyze financial performance and financial capacity in implementing regional autonomy. The object of this research is financial performance and financial capacity in the implementation of regional autonomy in 2011 to 2017. The data collection techniques of this study describe, analyze and interpret the financial performance and financial capabilities of the Regency / City government of Southeast Sulawesi Province which are measured by calculating financial ratios based on reports realization of APBD for fiscal year 2011-2017 and presented in writing in a systematic manner. The results of this study found that financial performance is still not financially independent and is in an innovative relationship pattern, where external parties are still very much needed in government administration, the effectiveness of PAD is very good and indirect expenditure activities in parent regions are allocated more than 50 percent, while for autonomous regions direct expenditure is allocated more than 50 percent, financial capability measured by the degree of fiscal autonomy is in the very low category but the financial ability index is very good. Keywords: Regional Autonomy, Financial Ability, Financial Performance
ANALISIS KINERJA KOPERASI PEGAWAI NEGERI (KPN)
Authors: YENI YENI , Rosnawintang Rosnawintang , Nusantara Ambo Wonua 
Published: March 2022

Penelitian ini bertujuan untuk menganalisis kinerja Koperasi Pegawai Negeri (KPN) Lingkup Pemerintah Provinsi Sulawesi Tenggara dan faktor yang mempengaruhi kinerja Koperasi Pegawai Negeri (KPN) Lingkup Pemerintah Provinsi Sulawesi Tenggara. Lokasi penelitian ini adalah dua Koperasi Pegawai Negeri Lingkup Pemerintah Provinsi Sulawesi Tenggarayaitu Koperasi Takdir pada Dinas Koperasi dan UMKM dan KPN Niaga di Dinas Perindustrian dan Perdagangan Provinsi Sulawesi Tenggara. Hasil penelitian menemukan bahwa Kinerja Kinerja pada KPN Niaga (Dinas Perindustrian dan perdagangan Provinsi Sulawesi Tenggara) berada pada ketagori cukup baik, sementara kinerja KPN Takdir (Dinas Koperasi dan UMKM Provinsi Sulawesi Tenggara) dari keempat perspektif Balanced Scorecard berada pada kategori buruk dan Kinerja KPN lingkup Pemerintah provinsi Sulawesi Tenggara dilihat dari empat aspek sebagai berikut a) aspek keuangan dipengaruhi oleh faktor kepemimpinan, kemampuan pengurus dan dukungan anggota, b) aspek pelanggan dipengaruhi oleh faktor kepemimpinan, kemampuan pengurus dan teknologi, c) aspek proses bisnis dipengaruhi oleh kepemimpinan, kemampuan pengurus, dukungan anggota dan teknologi dan d) aspek pembelajaran dan pertumnbuhan dipengaruhi oleh faktor kepemimpinan. Kata Kunci : Kinerja , Koperasi Pegawai Negeri, Kemampuan penguirus koperasi
EFEKTIVITAS SIKLUS PENGELOLAAN BARANG MILIK NEGARA STUDI PADA UNIVERSITAS HALU OLEO KENDARI
Authors: Inthe Desryani Ayulin , Mas’ud Arifuddin , Saranani Fajar 
Published: March 2022

Penelitian ini bertujuan untuk Untuk mengkaji siklus pengelolaan BMN Negara dalam konteks Perencanaan, pengadaan, penggunaan, pemanfaatan, pengamanan dan pemeliharaan, penilaian, pemusnahan, penghapusan, pemindahtangan, penatausahaan, serta pembinaan dan pengawasan dalam pengelolaan BMN pada Universitas Halu Oleo. Penelitian ini merupakan penelitian deskriptif kuantitatif dengan sumber data berasal dari wawancara dan kuesioner dan dokumen-dokumen terkait. Teknik pengambilan sampel dalam penelitian ini menggunakan Purposive sampling, dengan teknik pengumpulan data wawancara, kuesioner, observasi dan dokumentasi. Subjek penelitian adalah pejabat, staf pengelola, pengadministrasi Barang Milik Negara, serta operator SIMAK BMN pada Universitas Halu Oleo yang diwakili dengan 17 orang. Analisa data dimulai dengan tahap pengumpulan data, distribusi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan pengelolaan Barang Milik Negara belum sepenuhnya maksimal sesuai dengan peraturan yang berlaku; penatausahaan perlu ditingkatkan agar pencatatan kedalam aplikasi SIMAK BMN dapat dilakukan dengan baik; peningkatan pengawasan terhadap kegiatan pengelolaan BMN agar sesuai dengan Peraturan Pemerintah Nomor 27 tahun 2014.Kata Kunci : Pengelolaan BMN, Siklus Pengelolaan
A Prognostic Model Based on mRNA Expression Analysis of Esophageal Squamous Cell Carcinoma
Authors: Liu Ke , Jiao Ye-Lin , Shen Liu-Qing , Chen Pan , Zhao Ying , Li Meng-Xiang , Gu Bian-Li , Lan Zi-Jun , Ruan Hao-Jie , Liu Qi-Wei , Xu Feng-Bo , Yuan Xiang , Qi Yi-Jun , Gao She-Gan 
Published: March 2022

Background:The aim of this study was to identify prognostic markers for esophageal squamous cell carcinoma (ESCC) and build an effective prognostic nomogram for ESCC.Methods:A total of 365 patients with ESCC from three medical centers were divided into four cohorts. In the discovery phase of the study, we analyzed transcriptional data from 179 cancer tissue samples and identified nine marker genes using edgeR and rbsurv packages. In the training phase, penalized Cox regression was used to select the best marker genes and clinical characteristics in the 179 samples. In the verification phase, these marker genes and clinical characteristics were verified by internal validation cohort (n = 58) and two external cohorts (n= 81,n= 105).Results:We constructed and verified a nomogram model based on multiple clinicopathologic characteristics and gene expression of a patient cohort undergoing esophagectomy and adjuvant radiochemotherapy. The predictive accuracy for 4-year overall survival (OS) indicated by the C-index was 0.75 (95% CI, 0.72–0.78), which was statistically significantly higher than that of the American Joint Committee on Cancer (AJCC) seventh edition (0.65). Furthermore, we found two marker genes (TM9SF1, PDZK1IP) directly related to the OS of esophageal cancer.Conclusion:The nomogram presented in this study can accurately and impersonally predict the prognosis of ESCC patients after partial resection of the esophagus. More research is required to determine whether it can be applied to other patient populations. Moreover, we found two marker genes directly related to the prognosis of ESCC, which will provide a basis for future research.
Case Report: Synchronous Removal and Implantation of Peritoneal Dialysis Catheter Using Bilateral Transversus Abdominis Plane Block
Authors: Jakšić Ante , Vujičić Božidar , Deša Diana , Gršković Antun , Vukelić Ivan , Španjol Josip , Rački Sanjin , Markić Dean 
Published: March 2022

BackgroundPeritoneal dialysis (PD) surgery include PD catheter insertion and removal. Both procedures require the use of anesthesia. The end-stage renal disease (ESRD) patients usually have severe comorbidities. The general anesthesia, because of its negative systemic effect, should be omitted in this vulnerable group of the patients. Transversus abdominis plane (TAP) block as a newer method of regional anesthesia is a technique without systemic effect and recently started to be used in ESRD patients for PD catheter placement and/or removal. Here we report a patient in whom we for the first time simultaneously removed and implanted a PD catheter by using a bilateral transversus abdominis plane block.Case PresentationThe patient was an 80-year-old man who was admitted for removal of malfunctioned PD catheter. Since the patient opted for staying on PD simultaneous implantation of catheter was planned. Because of his age and significant comorbidities, general anesthesia was avoided and bilateral TAP block become our option. In the same anesthesia, using bilateral TAP block, the old PD catheter was removed and a new one was implanted. Until now the patient is on regular PD without any complications.ConclusionThe TAP block could be used as a primary anesthetic technique in ESRD patients for PD surgery even for synchronous removal and implantation of PD catheter.
Effects of Moringa oleifera in Two Independents Formulation and as Neuroprotective Agent Against Scopolamine-Induced Memory Impairment in Mice
Authors: Arozal Wawaimuli , Purwoningsih Emni , Lee Hee Jae , Barinda Agian Jeffilano , Munim Abdul 
Published: March 2022

BackgroundThe cognitive deficit has frequently been found in the elderly population. Several studies have shown that every single part of Moringa oleifera, including leaves, roots, and seeds, has abundant micronutrients, such as flavonoids, which improve the neurobehavioral capacity. However, herb parts that display optimal neuropharmacological properties remain unknown.ObjectiveWe investigate whether M. oleifera seed oil (MOO) or aqueous M. oleifera leaves extracts (MOEs) may ameliorate memory impairment in mice induced with scopolamine (Sco). Additionally, the phytochemical analyses of those two independent formulations were analyzed.MethodsIn this study, 2 ml/kg body weight (BW) of MOO and 500 mg/kg BW of MOE were orally administered to the mice for 28 days, followed by intraperitoneal injection of Sco (1 mg/kg) at the day 22–28 to induce cognitive impairment in those mice.ResultsThe Sco group showed memory retention impairment represented by the Y-maze and novel object recognition tests, significant enhancement of acetylcholine esterase (AChE) activity in hippocampus tissue (p &lt; 0.0001), and increased the level of total antioxidant capacity (TAOC) in serum. Interestingly, the Sco-induced memory defect was improved and completely blunted the AChE exacerbation in Sco+MOO-treated mice (p &lt; 0.0001), although the TAOC level was comparable among the groups. Mechanistically, both tropomyosin receptor kinase B (TrkB), as a brain-derived neurotrophic factor-receptor, and nuclear factor-kappa-light-chain-enhancer of activated B cells (NF-κB) protein expressions were enhanced with the hippocampus isolated from the Sco group. Nonetheless, pretreatment with MOO only, but not with MOE, ameliorated the enhanced protein expression levels of TrkB and NF-κB (p &lt; 0.05 and p = 0.09, respectively).ConclusionOur data reveal that MOO is preferable to MOE as a neuroprotective as evidenced by improving memory impairment. This effect, at least in part, through inhibiting the AChE and NF-κB activities and modulating the TrkB expression level.
Retinoic Acid-Induced 2 (RAI2) Is a Novel Antagonist of Wnt/β-Catenin Signaling Pathway and Potential Biomarker of Chemosensitivity in Colorectal Cancer
Authors: Zhang Weitao , Kong Lu , Zhu Hongbin , Sun Decong , Han Quanli , Yan Bin , Cui Zhi , Zhang Weiwei , Zhang Shurong , Kang Xindan , Dai Guanghai , Qian Niansong , Yan Wenji 
Published: March 2022

ObjectiveAberrant activation of Wnt/β-catenin signaling contributes to the maintenance of cancer stem cells and chemoresistance in colorectal cancer (CRC). Retinoic acid-induced 2 (RAI2) was proved to be a tumor suppressor in CRC in our previous report. In this study, the role of RAI2 in Wnt/β-catenin signaling was further investigated.MethodsAs a transcriptional co-regulator, C-terminal Binding Protein 2 (CtBP2) was reported to be involved in Wnt signaling in multiple and complex ways. The correlation of RAI2 and CtBP2 in CRC was analyzed by TCGA dataset, and the interaction between RAI2 and CtBP2 was explored by co-immunoprecipitation (Co-IP) in CRC cells. The effect of RAI2 on the activity of Wnt signaling and the location of β-catenin was detected by Dual-Luciferase reporter assay and Immunofluorescence respectively. Western blotting analysis was performed to detect the expression of target genes involved in Wnt signaling. Sphere formation assay was employed to detect the effect of RAI2 on stem cell like properties. Cell viability assay was used to detect the chemosensitivity of cells before and after transfection of RAI2.ResultsThe interaction between RAI2 and CtBP2 was confirmed by Co-IP in CRC cells. Besides, the negative correlation of RAI2 and CtBP2 in CRC was found by analyzing the TCGA dataset. Re-expression of RAI2 in human colon cancer cells (HCT116 and LoVo) suppressed the fluorescent activity of Wnt signaling, increased the phosphorylation and inhibited nuclear translocation of β-catenin, with down-regulation of target genes like c-Myc, CyclinD1, ASCL2, and LGR5. In contrast, the mutated RAI2, which can’t interact with CtBP2, has no above effects. We observed low expression of RAI2 in 33.89% (101/298) of CRC patients, which was significantly associated with reduced phosphorylation of β-catenin (r=0.8866, P&lt;0.0001), poor 5-year relapse-free survival (RFS) (P = 0.0029) and overall survival (OS) (P = 0.0102). Restoration of RAI2 in HCT116 and LoVo cells inhibited stem cell-like properties of CRC cells and increased chemosensitivity of these cells to oxaliplatin and fluorouracil.ConclusionLow expression of RAI2 can serve as an independent poor prognostic marker. RAI2 inhibits Wnt signaling by interacting with or down-regulating CtBP2, resulting in repression of stem cell-like properties and increased chemosensitivity of CRC cells.
Effect of Supervised Resistance Training on Arm Volume, Quality of Life and Physical Perfomance Among Women at High Risk for Breast Cancer-Related Lymphedema: A Study Protocol for a Randomized Controlled Trial (STRONG-B)
Authors: Ramírez-Parada Karol , Lopez-Garzon Maria , Sanchez-Rojel Cesar , Petric-Guajardo Militza , Alfaro-Barra Margarita , Fernández-Verdejo Rodrigo , Reyes-Ponce Alvaro , Merino-Pereira Gina , Cantarero-Villanueva Irene 
Published: March 2022

ObjectivesTo determine the preventive effects of supervised resistance training on arms volume, quality of life, physical performance, and handgrip strength in Chilean women at high risk for breast cancer-related lymphedema (BCRL) undergoing chemotherapy.DesignRandomized control trial.ParticipantsOne hundred and six women at high risk for breast cancer-related lymphedema aged 18 to 70 years.InterventionsParticipants will be randomized into two groups: [a] intervention, who will receive 12 weeks of supervised resistance training (STRONG-B) during adjuvant chemotherapy; and [b] control, who will receive education to promote lymphatic and venous return, maintain range of motion, and promote physical activity.Main Outcome MeasuresThe primary outcome will be arms volume measured with an optoelectric device (perometer NT1000). Secondary outcomes will be quality of life, handgrip strength, and physical performance. Primary and secondary outcomes will be measured at baseline, just after the intervention, and 3 and 6 months after. Statistical analysis will be performed following intention-to-treat and per-protocol approaches. The treatment effect will be calculated using linear mixed models.DiscussionThe STRONG-B will be a tailored supervised resistance training that attempts to prevent or mitigate BCRL in a population that, due to both intrinsic and extrinsic factors, will commonly suffer from BCRL.Clinical Trial Registration[https://clinicaltrials.gov/ct2/show/NCT04821609], identifier NCT04821609.
Prevalence and Health-Adjusted Life Expectancy Among Older Adults With Hypertension in Chinese Rural Areas
Authors: Hu Ze , Liu Xiaotian , Liao Wei , Kang Ning , Ma Lixia , Mao Zhenxing , Hou Jian , Huo Wenqian , Li Yuqian , Wang Chongjian 
Published: March 2022

BackgroundThe objectives of the present study were to explore the epidemiological characteristics of hypertension among rural older adults in resource-limited regions, and then evaluate the loss of health-adjusted life expectancy due to hypertension.MethodsParticipants aged between 60 and 79 years were enrolled from Henan rural cohort study. The prevalence, awareness, treatment, and control of hypertension were detailed across subgroups. Variances within subgroups were identified via Student's t tests or one-way ANOVA for continuous variables and chi-squared tests for categorical ones, and logistic regression model was employed to detect the potential influencing factors. The health-adjusted life expectancy was calculated by the Sullivan method with EuroqOL-5D data.ResultsAmong 16,785 participants, 7,472 (44.52%) were attacked by hypertension, 4,858 (65.02%) had been already aware of their condition, 4,009 (53.65%) were taking antihypertensive medication for treatment, while only 1,478 (19.78%) had their hypertension controlled. The prevalence of hypertension was significantly higher among women than men and it increased with age for both genders. For the older ones aged 60 years, the life expectancy was 22.0872 years and the health-adjusted life expectancy was 15.5578 and 15.9418 for those with or without hypertension, respectively. Namely, in this particular age group, subjects without hypertension could gain 0.3840 years of health-adjusted life expectancy.ConclusionThe prevalence of hypertension was relatively high while the awareness, treatment, and control were fairly low. The health-adjusted life expectancy of older adults in resource-limited areas could increase from the reduction of hypertension. There is an urgent need for strategies pertaining to the prevention and treatment of hypertension.Clinical Trial RegistrationThe Henan Rural Cohort Study has been registered at the Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699). Date of registration: 06 July, 2015. http://www.chictr.org.cn/showproj.aspx?proj=11375.
Gaitada Antijen Testi Helikobakter Pilori Enfeksiyonu Tanısında Yeterli midir?
Authors: DEMİRAL SEZER Sibel 
Published: March 2022

Giriş ve Amaç: Helikobakter pilori (Hp) enfeksiyonu tanısında invaziv ve non-invaziv testler mevcuttur. Bu testler içerisinde endoskopik biopsi altın standarttır. Bu çalışmada; Hp tanısında kullanılan gaitada antijen testinin özgüllük ve duyarlılığını mide endoskopik biopsisi ile karşılaştırmayı amaçladık.
Gereç ve Yöntemler: Sağlık Bilimleri Üniversitesi Tepecik Eğitim ve Araştırma hastanesi iç hastalıkları polikliniğine Ocak 2016-Nisan 2018 tarihleri arasında dispeptik şikayetler ile başvuran toplam 220 hasta geriye dönük taranmıştır. Bu hastalardan; eşzamanlı Hp tanısı için gaitada antijen ve endoskopik biopsi yapılan, her iki tanı testi arasında antibiyotik ve proton pompa inhibitörü almamış olan 74 hasta çalışmaya dahil edilmiştir.
Bulgular: Gaitada Hp antijeni pozitif saptanan 45 hastanın 42 (%93,3)’sinde endoskopik biopsi pozitif iken; gaitada Hp antijeni negatif saptanan 29 hastanın 3 (%10,3)’ünde endoskopik biopside Hp pozitif saptandı. Endoskopik biopsi ile karşılaştırıldığında gaitada Hp antijeninin duyarlılığı %93.3, özgüllüğü %89,6, pozitif prediktif değeri %93,3, negatif prediktif değeri %89,6 olarak bulunmuştur. Hp tespitinde kitin duyarlılığı %94’ün üzerinde kabul edilmektedir. Bu çalışmada da sonuçlar benzerdir (%93,3).
Sonuç: Dispeptik şikayetleri olan ve maligniteden şüphelenilmeyen durumlarda Hp tanısı için endoskopi yerine gaitada antijen testi güvenle bakılabilir.
Diagnostic Efficacy of Perfusion Index and Pleth Variability Index in Patients Admitted to the Emergency Department with Chest Pain
Authors: GÜLLÜ Durali , ARMAGAN Hamit Hakan , KARAMAN Kivanç 
Published: March 2022

Objective: Acute coronary syndrome (ACS) is the leading cause of death worldwide. Therefore, rapid differential diagnosis and treatment is required in patients who present to the emergency department (ED) with chest pain. In this disorder, in which rapid diagnosis and treatment are life-saving, novel diagnostic methods are being proposed every day. This study aimed to reveal the contributions of the Perfusion Index (PI) and the Pleth Variability Index (PVI) measurements to management of patients with chest pain.
Materials and Methods: PI and PVI measurements were carried out during routine clinical procedure by a trained
triage nurse who was blinded to the study using the Masimo Radical 7 Pulse Oximetry Device in all adult patients who were admitted to the ED with the complaint of chest pain between April 1st, 2019 and October 1st, 2019. The demographic characteristics, PI, PVI, HEART score, ECG findings, and troponin levels were recorded.

Results: A total of 154 patients, 96 (62.3%) of whom were males, were included in our study. The mean age was calculated as 55.1 ±18.2 years in men, 56.8 ±20.2 years in women, and 56.3±18.9 years in total. Of all patients, 66 (42.8%) were hospitalized with ACS diagnosis, and 88 (57.2%) were discharged from ED. The hospitalized patients had statistically higher values for Troponin, HEART score, and mean age. There was no difference between the two groups regarding PI and PVI.
Conclusion: We think that the contributions of PI and PVI to emergency physicians in the management of patients who are evaluated with suspicion of ACS in the ED will be limited.