bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electronic Medical Record–Based Machine Learning Approach to Predict the Risk of 30-Day Adverse Cardiac Events After Invasive Coronary Treatment: Machine Learning Model Development and Validation
Authors: Kwon Osung , Na Wonjun , Kang Heejun , Jun Tae Joon , Kweon Jihoon , Park Gyung-Min , Cho YongHyun , Hur Cinyoung , Chae Jungwoo , Kang Do-Yoon , Lee Pil Hyung , Ahn Jung-Min , Park Duk-Woo , Kang Soo-Jin , Lee Seung-Whan , Lee Cheol Whan , Park Seong-Wook , Park Seung-Jung , Yang Dong Hyun , Kim Young-Hak 
Published: January 2022

Background
Although there is a growing interest in prediction models based on electronic medical records (EMRs) to identify patients at risk of adverse cardiac events following invasive coronary treatment, robust models fully utilizing EMR data are limited.

Objective
We aimed to develop and validate machine learning (ML) models by using diverse fields of EMR to predict the risk of 30-day adverse cardiac events after percutaneous intervention or bypass surgery.

Methods
EMR data of 5,184,565 records of 16,793 patients at a quaternary hospital between 2006 and 2016 were categorized into static basic (eg, demographics), dynamic time-series (eg, laboratory values), and cardiac-specific data (eg, coronary angiography). The data were randomly split into training, tuning, and testing sets in a ratio of 3:1:1. Each model was evaluated with 5-fold cross-validation and with an external EMR-based cohort at a tertiary hospital. Logistic regression (LR), random forest (RF), gradient boosting machine (GBM), and feedforward neural network (FNN) algorithms were applied. The primary outcome was 30-day mortality following invasive treatment.

Results
GBM showed the best performance with area under the receiver operating characteristic curve (AUROC) of 0.99; RF had a similar AUROC of 0.98. AUROCs of FNN and LR were 0.96 and 0.93, respectively. GBM had the highest area under the precision-recall curve (AUPRC) of 0.80, and the AUPRCs of RF, LR, and FNN were 0.73, 0.68, and 0.63, respectively. All models showed low Brier scores of <0.1 as well as highly fitted calibration plots, indicating a good fit of the ML-based models. On external validation, the GBM model demonstrated maximal performance with an AUROC of 0.90, while FNN had an AUROC of 0.85. The AUROCs of LR and RF were slightly lower at 0.80 and 0.79, respectively. The AUPRCs of GBM, LR, and FNN were similar at 0.47, 0.43, and 0.41, respectively, while that of RF was lower at 0.33. Among the categories in the GBM model, time-series dynamic data demonstrated a high AUROC of >0.95, contributing majorly to the excellent results.

Conclusions
Exploiting the diverse fields of the EMR data set, the ML-based 30-day adverse cardiac event prediction models demonstrated outstanding results, and the applied framework could be generalized for various health care prediction models.
Aerobic Exercise in HIV-Associated Neurocognitive Disorders: Protocol for a Randomized Controlled Trial
Authors: Nweke Martins , Mshunqane Nombeko , Govender Nalini , Akinpelu Aderonke , Ogunniyi Adesola 
Published: January 2022

Background
Since the introduction of antiretroviral therapy (ART), the incidence of HIV-associated dementia has drastically fallen. Despite using ART, people living with HIV continue to experience less severe but limiting forms of HIV-associated neurocognitive disorder (HAND). People living with HIV who are on ART and experiencing symptoms of HAND may benefit from aerobic exercise.

Objective
This protocol describes a randomized controlled trial designed to determine the effects of a 12-week aerobic exercise program on HAND in Southeastern Nigeria.

Methods
At least 68 patients diagnosed with HAND will be randomly placed into either an aerobic exercise group or control group. Patients in the aerobic exercise group will perform a moderate intensity workout on a stationary bicycle ergometer, 3 times a week for 12 weeks. We will measure the primary outcomes including neurocognitive performance, prevalence of HAND, viral load, and CD4 count. We will evaluate postexercise neurocognitive performance using reliable neuropsychological tests relevant to people living with HIV, in line with the Frascati criteria. We will assess secondary outcomes such as quality of life, activity limitation, and social participation using the World Health Organization Quality of Life (WHOQOL)-Brief, and the Oxford Participation and Activities questionnaire. We will use exploratory statistics to test the data for normality and homogeneity. We will analyze the effect of the exercise program on HAND using relative risk (RR) and absolute risk reduction (number needed to treat). Analysis of covariance will be run to estimate the effect of exercise on quality of life and activity and participation level.

Results
This funded trial was approved by the Institutional Review Board in May 2020. The protocol was approved on June 15, 2020. Enrollment commenced in January 2021 and was completed in May 2021. Over 60% of the participants were recruited at the time of first submission to JMIR Mental Health. Data curation is still ongoing; hence, data analysis is yet to be executed. Study outcomes are expected to be published in March 2022.

Conclusions
This is a protocol for a randomized controlled trial that aims to evaluate the effect of a 12-week aerobic exercise program on HAND in Southeastern Nigeria.

Trial Registration
Pan African Clinical Trials Registry PACTR202009483415745; https://tinyurl.com/2p97zpu9

International Registered Report Identifier (IRRID)
PRR1-10.2196/29230
Machine Learning Support for Decision-Making in Kidney Transplantation: Step-by-step Development of a Technological Solution
Authors: Paquette François-Xavier , Ghassemi Amir , Bukhtiyarova Olga , Cisse Moustapha , Gagnon Natanael , Della Vecchia Alexia , Rabearivelo Hobivola A , Loudiyi Youssef 
Published: January 2022

Background
Kidney transplantation is the preferred treatment option for patients with end-stage renal disease. To maximize patient and graft survival, the allocation of donor organs to potential recipients requires careful consideration.

Objective
This study aimed to develop an innovative technological solution to enable better prediction of kidney transplant survival for each potential donor-recipient pair.

Methods
We used deidentified data on past organ donors, recipients, and transplant outcomes in the United States from the Scientific Registry of Transplant Recipients. To predict transplant outcomes for potential donor-recipient pairs, we used several survival analysis models, including regression analysis (Cox proportional hazards), random survival forests, and several artificial neural networks (DeepSurv, DeepHit, and recurrent neural network [RNN]). We evaluated the performance of each model in terms of its ability to predict the probability of graft survival after kidney transplantation from deceased donors. Three metrics were used: the C-index, integrated Brier score, and integrated calibration index, along with calibration plots.

Results
On the basis of the C-index metrics, the neural network–based models (DeepSurv, DeepHit, and RNN) had better discriminative ability than the Cox model and random survival forest model (0.650, 0.661, and 0.659 vs 0.646 and 0.644, respectively). The proposed RNN model offered a compromise between the good discriminative ability and calibration and was implemented in a technological solution of technology readiness level 4.

Conclusions
Our technological solution based on the RNN model can effectively predict kidney transplant survival and provide support for medical professionals and candidate recipients in determining the most optimal donor-recipient pair.
Impacto de la pandemia por COVID-19 en la salud mental
Authors: Morales-Chainé S. 
Published: January 2022

El riesgo de contagio por el virus del SARS-CoV-2, causante de la COVID-19, inició en el mundo a finales del 2019 en Hubei, China. Para el momento de esta edición existían más de 176,480,226 personas diagnosticadas con la enfermedad y 3,825,240 fallecidas en el mundo. En México, se reporta una Tasa de Fatalidad por Caso del 9.4% (CFR por sus siglas en inglés).
Referente a la COVID-19, revisiones sistemáticas en la literatura internacional y meta análisis han señalado la prevalencia de otra pandemia asociada a la COVID-19, se trata de los riesgos a la salud mental por el uso de sustancias psicoactivas y las diversas condiciones neurológicas actuales. De acuerdo con Lancet, 17% de 116 países habían referido la necesidad de atender tales condiciones de riesgo relacionadas con la aparición de la COVID-19, desde mediados del 2020.
Rol social de la enfermería profesional en la Vicaría de la Solidaridad, Chile 1976–1992
Authors: Ferrada-Herrera R.C. , Rivas-Riveros E.E. 
Published: January 2022

Introducción: Durante la dictadura militar en Chile hubo cambios sociales en la política de seguridad social que significaron persecuciones, torturas y muerte de miles de personas, situación que impulsó la creación de la Vicaría de la Solidaridad, la cual implementó distintos programas dentro de los cuales estuvo el área de salud.
Objetivo: Develar el rol social de la enfermería profesional en la Vicaría de la Solidaridad en Chile, años 1976-1992.
Metodología: Investigación cualitativa, diseño historia de vida, con entrevistas en profundidad a cinco enfermeras y un enfermero, integrantes de la Vicaría, seleccionados por muestreo intencionado. Como sustento teórico, se utilizó la Teoría de Margaret Newman. Se realizó análisis textual y conceptual. Se cumplieron las implicancias éticas y consentimiento informado.
Resultados: Se develan las metacategorías: a) función asistencial, b) función educativa, c) función administrativa y, d) función investigación.
Discusión: La esencia social de la enfermería es la ejecución de acciones coherentes con el contexto en el que se encuentra para favorecer la protección y engrandecimiento de la dignidad humana. Existe coherencia entre los resultados obtenidos y la literatura sobre el tema propuesto.
Conclusión: Las enfermeras se caracterizaron por poseer un profundo compromiso social y deber ético, así como habilidades de observación, coordinación, análisis, liderazgo y toma de decisiones, que las transformaron en agentes de cambio en la población. Este estudio abre una línea de investigación sobre la historia de la enfermería en Chile y su acción social en momentos de crisis.
Primary Prevention of Cardiovascular and Heart Failure Events With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Their Combination in Type 2 Diabetes
Authors: Wright Alison K. , Carr Matthew J. , Kontopantelis Evangelos , Leelarathna Lalantha , Thabit Hood , Emsley Richard , Buchan Iain , Mamas Mamas A. , van Staa Tjeerd P. , Sattar Naveed , Ashcroft Darren M. , Rutter Martin K. 
Published: January 2022

OBJECTIVE
To assess associations between current use of sodium–glucose cotransporter 2 inhibitors (SGLT2is), glucagon-like peptide 1 receptor agonists (GLP-1RAs), and their combination and risk for major adverse cardiac and cerebrovascular events (MACCE) and heart failure (HF) in people with type 2 diabetes.

RESEARCH DESIGN AND METHODS
In three nested case-control studies involving patients with type 2 diabetes in England and Wales (primary care data from the Clinical Practice Research Datalink and Secure Anonymised Information Linkage Databank with linkage to hospital and mortality records), we matched each patient experiencing an event with up to 20 control subjects. Adjusted odds ratios (ORs) for MACCE and HF among patients receiving SGLT2i or GLP-1RA regimens versus other combinations were estimated using conditional logistic regression and pooled using random-effects meta-analysis.

RESULTS
Among 336,334 people with type 2 diabetes and without cardiovascular disease, 18,531 (5.5%) experienced a MACCE. In a cohort of 411,206 with type 2 diabetes and without HF, 17,451 (4.2%) experienced an HF event. Compared with other combination regimens, the adjusted pooled OR and 95% CI for MACCE associated with SGLT2i regimens was 0.82 (0.73, 0.92), with GLP-1RA regimens 0.93 (0.81, 1.06), and with the SGLT2i/GLP-1RA combination 0.70 (0.50, 0.98). Corresponding data for HF were SGLT2i 0.49 (0.42, 0.58), GLP-1RA 0.82 (0.71, 0.95), and SGLT2i/GLP-1RA combination 0.43 (0.28, 0.64).

CONCLUSIONS
SGLT2i and SGLT2i/GLP-1RA combination regimens may be beneficial in primary prevention of MACCE and HF and GLP-1RA for HF. These data call for primary prevention trials using these agents and their combination.
Analisis Faktor-Faktor Yang Mempengaruhi Kepatuhan Wajib Pajak UMKM Selama Pandemi Covid-19
Authors: Oliviandy Nathania Aldisa , Astuti Titiek Puji , Siddiq Faiz Rahman 
Published: January 2022

This study aims to obtain empirical evidence the affect of tax rates, knowledge and understanding of taxation, perceptions of the effectiveness of the taxation system, and the level of trust in the legal and government systems towards taxpayer compliance. The sample in this study was taken using a purposive sampling method. The number of sample data processed was 340. Data collection using primary data sources in the form of a questionnaire was arranged with a five-point Likerts scale. The data analysis technique of this study used multiple linear regression analysis techniques. The result of analysis data in this research shows that the tax rate, knowledge and understanding of taxation, and the level of trust in the legal and government systems has a positive effect on taxpayer compliance, while the perceptions of the effectiveness of the taxation system has a negative effect on taxpayer compliance.Keywords: Knowledge; Effectiveness; Legal; Taxpayer Compliance.
Underpricing Saham pada Saat Initial Public Offering (IPO): Pengaruh Ukuran Perusahaan, Umur Perusahaan, Reputasi KAP dan Profitabilitas
Authors: Mulyani Erly , Maulidya Rahmah 
Published: January 2022

The phenomenon that often occurs when a company conducts an Initial Public Offering (IPO) is underpricing, which means that the stock price determination in the primary market is lower than the price of the same stock after being traded on the secondary market. This study examined the effect of firm size, firm age, public accountant reputation and profitability of the underpricing. The population in this research are the companies that did the Initial Public Offering (IPO) in Indonesian Stock Exchange in the period of 2017-2020. The selection of the sample in this study using the purposive sampling method and retrieved 147 samples from 192 companies who are doing an initial public offering in BEI 2017-2020. This research use the multiple linear regression analysis. The results from t-test (partially) showed that public accountant reputation significantly effected on underpricing. While the firm size, firm age and profitability didn’t significantly effected the underpricing. The results from F-test (simultaneously) showed that firm size, firm age, public accountant reputation and profitability significantly effected the underpricing. Keywords: Firm Age; Firm Size; Profitability; Public Accountant Reputation; Underpricing.
Transfer Pricing dari Perspektif Perencanaan Pajak, Tunneling Incentives, dan Aset Tidak Berwujud
Authors: Wulandari Sartika , Oktaviani Rachmawati Meita , Hardiyanti Widhian 
Published: January 2022

Transactions with related parties are often used by companies to conduct transfer pricing. This study purpose to provide empirical evidence regarding the effect of tax planning, tunnelingsincentives and intangible assets on transfer pricing, either simultaneously or partially. The object of this research is manufacturing companies listed on the Indonesia Stock Exchanges in 2016-2019. The population in this study are manufacturing companies listed on the Indonesian Stock Exchanges for the period 2016-2019. By using purposive sampling technique data obtained 96 companies. Data analysis technique using Eviews. The results show that tax planning and tunneling incentives have an effect on transfer pricing, while intangible assets have no effect on transfer pricing. The results of this study are expected to provide input for future research on transfer pricing. Further research can use other variables such as KAP specialization, percentage of independent commissioners, or proxies to measure other intangible assets, such as research and development costs. For transfer pricing, you can use other proxies, for example by using an index. Keywords: Transfer Pricing; Tax Planning; Tunneling Incentives; Intangible Assets.
El contexto: elemento de análisis en la construcción de agencia profesional de docentes de inglés universitarios
Authors: Barrantes Lena 
Published: January 2022

El artículo presenta la propuesta y los resultados de una investigación sobre las experiencias de docentes de inglés universitarios en su construcción de agencia profesional en sedes universitarias. Las sedes universitarias si bien pertenecen a un mismo órgano de educación superior en Costa Rica, desconcentran el quehacer universitario en su máxima expresión en lo local. Al respecto, existe una realidad latente que identifica la persistencia de brechas de equidad de índole territorial. El estudio fue de corte cualitativo, desde el diseño de narrativa y de tipo historia de vida. Se indagó las historias de vida de los participantes desde el enfoque ecológico de agencia docente desarrollado por Priestley, Biesta y Robinson (2015). Partiendo de la premisa ecológica que la agencia profesional es una construcción temporal, el pasado, el presente y el futuro son las dimensiones claves en la búsqueda de su comprensión. Entre los principales resultados de esta narrativa se logra ver la influencia de las iteraciones de los docentes en experiencias pasadas en su alto sentido de pertenencia tanto a su institución como a su comunidad. El presente práctico-evaluativo reveló la vulnerabilidad de sus contextos desde la disponibilidad de recursos y políticas de regionalización. Finalmente, las aspiraciones de los participantes para su futuro proyectivo están enraizadas en la necesidad de ser un agente de cambio académico en su contexto local que procure la preparación de los estudiantes para servir los intereses de su comunidad y así asegurarse del impacto de la presencia universitaria en sus regiones.
La gran estafa de la "producción académica"
Authors: Caparrós Martín Ester , Martín Alonso Diego , Sierra Nieto J. Eduardo , Alcaraz  Salarirche Noelia , Fernández Navas Manuel , Portigo Fuentes Ana Yara , García García Mayka , Pérez Pérez Laura , Pérez García Álvaro , Montero González Javier 
Published: January 2022

Editorial de presentación del Volumen 3 número 1 de Márgenes, Revista de Educación de la Universidad de Málaga. Séptimo número de la revista, compuesto por un total de 17 textos, distribuidos en las diferentes secciones. Se trata de un número de carácter ecléctico en el que continuamos ofreciendo contenidos fieles a las premisas y los pilares educativos con los que partíamos.
Comparison of ground reaction forces and joint kinematics between three different tempos during push-up exercise
Authors: Degirmen Yahya Berk , Erman Berkant , Ozkol Mehmet Zeki , Vural Faik , Aksit Tolga 
Published: January 2022

Abstract

Study aim
This study was aimed to analysis in detail how different tempos [2:0:2 (30 bpm), 1:0:1 (60 bpm), Explosive (EXP)] effect to ground reaction forces (vGRF) and joint kinematics of push-up exercise (PUP).

Material and methods
Twenty-four recreationally male athletes (age: 24.9 ± 3.6 years) participated in this study. Kinetic and kinematic data were obtained by load-cells and a motion analysis software. Data was analysed from a single repetition which is showed peak vGRF of dominant side during PUP. Joint velocities were calculated by taking the difference between the descent and ascent phases.

Results
There was significant difference between 2:0:2 (30 bpm) – EXP in terms of dominant side of shoulder (p ≤ 0.02) and between 1:0:1 (60 bpm) – EXP in the dominant elbow joint displacements (p ≤ 0.05). The velocity differences between the descent and ascent phases of shoulder and elbow joints were found statistically significant between tempos (p ≤ 0.05). In terms of range of motion (ROM) of right and left side, there was significant differences between tempos (p ≤ 0.001). No significant differences were found between all tempos in the ascent phase of right-left and left descent phase in terms of average vGRF (p > 0.05) except right descent average vGRF (p ≤ 0.02).

Conclusions
In conclusion, right-left sides of ROM was used most effectively in 2:0:2 (30 bpm) and 1:0:1 (60 bpm) tempos. Less displacement was also observed in EXP and when tempo increased percentage of peak vGRF (at elbow flexion phase for right-left sides) to total repetition decreased. Highest ascent and descent phase velocity differences (for right-left sides) and highest peak vGRF (elbow flexion phase) observed in EXP. This study shows that increasing tempo will result in more unsteady joint kinematics and more vGRF, so if the goal is controlled and safe PUP, tempo should be slow.
The potential accessibility to workplaces and working-age population by means of public and private car transport in Szczecin
Authors: Goliszek Sławomir 
Published: January 2022

Abstract
Commuting to work is one of the key motivations for people to move around cities or other regions. For the purpose of this study, the city of Szczecin in Poland has been selected, where the modal division of transport includes public transport (bus, tram) and private transport (car). The maps present the spatial distribution of citizens within a working area as well as precise locations of workplaces registered in the REGON database. The main objective of this study is to analyse the potential accessibility of workplaces and the working-age population of the city using the abovementioned modes of transport, and to indicate the places less accessible by public transport and car for commuting purposes. The study presented herein is based on data from 2018. The calculated average accessibility by different means of public and private transport as well as the potential accessibility quotient are presented in the form of box plots.
PENGEMBANGAN MEDIA PEMBELAJARAN VIDEO PADA MATA KULIAH BAHASA INGGRIS DI ERA NEW NORMAL
Authors: Anum Adelina , Novalia Novalia 
Published: January 2022

Tujuan dari penelitian ini adalah untuk mengembangkan media pembelajaran video pada mata kuliah bahassa inggris di era new normal dan mengetahui kelayakan media pembelajaran video pada mata kuliah bahassa inggris di era new normal. Desain penelitian yang digunakan dalam penelitian ini adalah penelitian dan pengembangan (research and development. Model pengembangan ini terdiri dari lima tahapan yaitu analisis (analysis), desain (design), pengembangan (development), implementasi (implementation) dan evaluasi (evaluation).Penelitian ini dilakukan di Universitas Sang Bumi Ruwa Jurai dengan subjek penelitian yaitu mahasiswa Fakultas Hukum Semester satu. Hasil dari penelitian pengembangan ini berupa produk video pembelajaran yang telag diujikelayakannya oleh ahli media, ahli materi, peer review dan mahasiswa sebagai pengguna media tersebut. Keseluruhan hasil uji coba menunjukkan bahwa media pembelajaran ini sangat layak digunakan dalam proses pembelajaran Bahasa Inggris di era new normal. Rincian dari masing-masing hasil uji coba adalah a) uji ahli materi mendapatkan hasil rerata sebesar 90% yaitu masuk dalam kategori sangat layak, b) uji ahli media mendapatkan hasil rerata 90% yaitu masuk dalam kategori sangat layak, c)uji peer review mendapatkan hasil rerata 88% dengan kategori sangat layak dan uji mahasiswa mendapatkan hasil 85% yang termasuk dalam kategori sangat layak. Berdasarkan hasil uji kelayakan media pembelajaran tersebut dapat disimpulkan bahwa video pembelajaran layak untuk digunakan sebagai media pembelajaran pada mata kuliah Bahasa Inggris di era new normal.