bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic effect of ibrutinib, a selective Bruton’s tyrosine kinase inhibitor, in orbital fibroblasts from patients with Graves’ orbitopathy
Authors: Park Hyun Young , Chae Min Kyung , Ko JaeSang , Kikkawa Don O. , Jang Sun Young , Yoon Jin Sook 
Published: December 2022

PurposeBruton’s tyrosine kinase (BTK) is an essential protein in B-cell antigen receptor (BCR) signaling pathway and is known to be related to pathogenetic effect on B-cell related malignancies and various autoimmune diseases. In this study, we investigated the therapeutic effect of ibrutinib, an orally bioavailable BTK inhibitor in the pathogenesis of Graves’ orbitopathy (GO) inin vitromodel.MethodsExpression of BTK in orbital tissues from GO and normal control subjects were evaluated by real-time polymerase chain reaction (PCR). Primary cultured orbital fibroblasts from each subject were exposed to ibrutinib and stimulated with interleukin (IL)-1β or insulin like growth factor (IGF)-1. Production of inflammatory cytokines was evaluated by real time PCR and enzyme-linked immunosorbent assays (ELISA). The downstream transcription factors were also determined by western blot assays.ResultsThe expression of BTK in GO tissues were significantly higher than in healthy controls. After stimulation of GO orbital fibroblasts with IL-1β or IGF-1, BTK mRNA and phosphorylated (p)- BTK protein expression was also enhanced. Ibrutinib reduced the expression of BTK mRNA and proteins of p-BTK, and inhibited the IL-1β- and IGF-1-induced production of proinflammatory cytokines including IL-6, IL-8 and COX-2 in both GO and normal cells. Ibrutinib also significantly attenuated phosphorylation of Akt, p38, c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) in IL-1β stimulated GO cells and Akt, JNK, and NF-κB in IL-1ß stimulated normal cells.ConclusionsBTK expression is enhanced in GO tissue and orbital fibroblasts. Ibrutinib, a BTK inhibitor suppresses proinflammatory cytokine production as well as phosphorylation of Akt and NF-κB protein. Our results suggest the potential role of BTK in GO inflammatory pathogenesis and possibility of a novel therapeutic target of GO.
Differences by race in the associations between neighborhood crime and violence and glycemic control among adults with type 2 diabetes
Authors: Akinboboye Olaitan , Williams Joni S. , Olukotun Oluwatoyin , Egede Leonard E. 
Published: December 2022

Background
Limited data exist on the differential association between neighborhood characteristics such as crime and violence and diabetes outcomes by race.

Objective
To examine racial differences in the relationship between neighborhood characteristics (crime and violence) and glycemic control in a sample of adults with type 2 diabetes (T2DM).

Design
A cross-sectional study.

Participants
601 adults with T2DM from the Southeastern United States.

Measurements
Outcome was glycemic control. Neighborhood violence and crime were the primary independent variable, and previously validated scales and indices were used to assess neighborhood crime and violence. Covariates included age, gender, education, marital status, income, hours of work per week, duration of diabetes, comorbidity, health status, and site of recruitment. Multiple linear regression was used to assess the relationship between neighborhood characteristics (violence and crime) and glycemic control adjusting for relevant covariates.

Results
Approximately 66% of the sample population was Black with ages ranging between 49–71 years. The unadjusted mean hemoglobin A1c (HbA1c) was significantly higher for Black adults compared to White adults (8.0 ± 2.0 vs. 7.8 ± 1.6; p = 0.002). In the fully adjusted stratified model, glycemic control was significantly associated with neighborhood crime (β-coefficient: 0.36; 95% CI 0.07, 0.65) and neighborhood violence (β-coefficient: 0.14; 95% CI 0.003, 0.28) for White adults in the fully adjusted model; these relationships were not significant for Black adults.

Conclusion
In this sample of adults with T2DM, neighborhood crime and violence were significantly associated with glycemic control for White adults, but not for Black adults. Additional research is needed to understand perceptions of neighborhood crime and violence between White adults and Black adults with T2DM.
Effect of Paclitaxel Drug-Coated Balloon Angioplasty of Infrapopliteal Lesions on Mortality
Authors: Böhme Tanja , Beschorner Ulrich , Noory Elias , Molitor Miriam , Nührenberg Thomas , Neumann Franz-Josef , Zeller Thomas 
Published: December 2022

Background
Meta-analyses of randomized controlled trials have suggested an increased long-term mortality risk following femoropopliteal and infrapopliteal angioplasty using paclitaxel-coated devices. This study was conducted to evaluate long-term mortality after paclitaxel drug-coated balloon (DCB) and plain old balloon angioplasty (POBA) of infrapopliteal lesions in real-world practice.

Methods
A retrospective mortality analysis of patients with at least 3 years of follow-up who underwent balloon-based endovascular therapy of infrapopliteal lesions was performed.

Results
Overall, 2,424 patients with infrapopliteal lesions were treated within the study period. Five hundred seventy-six patients fulfilled the study criteria. Of those, 269 patients were treated with uncoated devices without crossover to a paclitaxel-coated device during follow-up and 307 patients with DCB angioplasty. Mean (SD) follow-up was 46.48 (32.77) months. The mortality rate was 66.9% after POBA and 46.9% after DCB (P < .001). In the matched-pair cohort, 164 patients died after uncoated treatment (66.7%), and 119 in the DCB group died (48.4%; P < .001). There was no correlation between DCB length and mortality rate (P = .357). For the entire cohort, multivariate logistic regression analysis showed type of treatment (uncoated device vs DCB; P = .002), age (P < .001), stroke (P = .005), renal insufficiency (P = .014), and critical limb ischemia (P = .001) to be independent predictors of all-cause mortality. There was no significant difference in mortality among the paclitaxel exposure groups.

Conclusion
In this real-world retrospective analysis, the long-term mortality rate was lower after DCB angioplasty than after POBA of infrapopliteal lesions.
Chemical synthesis, characterization, and dose optimization of chitosan-based nanoparticles of clodinofop propargyl and fenoxaprop-p-ethyl for management of Phalaris minor (little seed canary grass): First report
Authors: Khan Bilal Ahmad , Nadeem Muhammad Ather , Javaid Muhammad Mansoor , Maqbool Rizwan , Ikram Muhammad , Oraby Hesham 
Published: December 2022

Abstract

Phalaris minor is the main and troublesome weed of wheat all over the globe. Chemical weed control is a quick and effective method for weed management. However, herbicides are criticized for environmental pollution and the development of resistance in weeds. Therefore, the present study was planned for chemical synthesis, characterization, and dose optimization of chitosan-based nanoparticles of clodinofop propargyl and fenoxaprop-p-ethyl for the management of Phalaris minor grown in wheat. Chitosan-based nanoparticles of clodinofop propargyl and fenoxaprop-p-ethyl were prepared by the ionic gelification technique. The nanoparticles (NPs) of clodinofop propargyl and fenoxaprop-p-ethyl were sprayed at 3–4 leaf stage of the P. minor weed. Seven different doses (D0 = weedy check, D1 = normal herbicide at recommended dose, D2 = nano herbicide at the recommended dose of normal herbicide, D3 = 5-fold lower dose of nano herbicide, D4 = 10-fold lower dose of nano herbicide, D5 = 15-fold lower dose of nano herbicide, and D6 = 20-fold lower dose of nano herbicide) were used. Chitosan-based NPs of herbicides were characterized using UV absorbance, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD) studies. SEM demonstrated particles in the cluster form with porous structure and the average size ranged from 30 to 60 nm. XRD results confirmed the existence of (2θ) peak at 29.79 related to 160 anatase form in the NPs of clodinofop propargyl and 24.65 related to 76 anatase form in the case of fenoxaprop-p-ethyl. The FT-IR analysis of chitosan-based NPs of both the herbicides perfectly matched the standard parameters. UV-visible spectra exhibited absorption peaks at 300 and 330 nm, for the NPs of fenoxaprop-p-ethyl and clodinofop, respectively. The chitosan-based particles of clodinofop propargyl and fenoxaprop-p-ethyl at the recommended dose of normal herbicide caused 100% mortality and visual injury. However, a 5-fold lower dose of chitosan-based NPs of clodinofop propargyl and fenoxaprop-p-ethyl caused the maximum visual injury (94.00%), mortality (93.75%), minimum chlorophyll contents (7.47%), plant height (cm), fresh biomass (0.27 g), and dry biomass (0.08 g) of P. minor. The chitosan-based NPs of clodinofop propargyl and fenoxaprop-p-ethyl at a 10-fold lower dose of normal herbicides and recommended dose produced a similar effect on the previously mentioned traits of P. minor.
Late Mesolithic Individuals of the Danube Iron Gates Origin on the Dnipro River Rapids (Ukraine)? Archaeological and Bioarchaeological Records
Authors: Haskevych Dmytro 
Published: December 2022

Abstract
In contrast to large-scale prehistoric migrations, associated with massive population shifts and changes in material culture, movements of small human groups or single individuals are barely visible but no less important. In publications of the 1960s–2000s, specificity of craniological, odontological, and metrical characteristics as well as stable isotope values of some individuals distinguishing the Late Mesolithic cemetery of Vasylivka II among other Mesolithic and Neolithic burial sites in the Dnipro River basin was explained by some gene flows. However, archaeologists could not develop these views since the original excavation report of 1953 and all grave goods from Vasylivka II were considered lost. Another old field document, where pendants of the pharyngeal teeth of fish, and the shells of spiral, probably Mediterranean, molluscs found there were mentioned, allowed the recent suggestion of the author of the current article that several individuals from the Danube Iron Gates region were interred in the cemetery. Previous arguments along with new evidence are presented here to develop this hypothesis. Re-found personal ornaments from one burial, the only available grave goods from Vasylivka II, are published here for the first time. The established regularity that most relatively young men and women from the graveyard have conditional “Danubian” δ13C values in the range from −20 to −21‰ assumes the mutual exchange of marriage partners born in the Iron Gates and the Dnipro Rapids. A waterborne route is discussed as a more probable mode of communication between these regions.
Comparison of clinical and radiological outcomes between extended lateral and sinus tarsi approach in the surgical treatment of displaced intraarticular calcaneal fractures surgery
Authors: ŞAHAN Kemal , POLAT Abdulkadir , KILIÇ Feyzi , KAZDAL Cengiz , FİDAN Fırat , ÖZKAYA Ufuk 
Published: December 2022

Purpose: The aim of this stud was to compare the clinical and radiological results between Sinus-tarsi (ST) and Extended-Lateral (EL) approaches in open reduction internal fixation of intra-articular calcaneal fractures.
Materials and Methods: 51 calcaneal fractures of 48 patients surgically treated between 2012 and 2017 were retrospectively analyzed. The patients were divided into two groups. Preoperative CT, early postoperative and postoperative 1st-year radiographs, and The American Orthopedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Score scores were evaluated.
Results: According to the Sanders classification, nine patients in the EL group were type 2(36%), 16 patients type 3 (64%), 8 patients in ST group type 234.8%), 13 patients (56.5%) type 3, 2 patients (8.7%) type 4. The mean AOFAS-Hindfoot score was 85(63-100) in the ST group and 83(52-93) in the LE group at one year. Mean preoperative waiting time was shorter, with an average of 2(1-4) days in ST and 6(3-12) days in LE.
Conclusion: ST approach shortens the preoperative waiting time in intra-articular calcaneal fracture surgery, provides a sufficient vision for anatomical restoration, and effectively avoids complications.
Comparison of early atherosclerosis markers in children with Celiac disease and their healthy peers
Authors: KARPUZ Derya , TEZOL Özlem , TÜRKEGÜN Merve , USTA Yusuf 
Published: December 2022

Purpose: We aimed to evaluate carotid intima-media thickness (cIMT) and epicardial adipose tissue thickness (EATT) concurrently as early atherosclerotic markers in pediatric patients with Celiac disease.
Materials and Methods: Patients with Celiac disease (n=54) and healthy peers (n=54) aged 5-18 years were enrolled in this cross-sectional study. Patients who followed gluten free diet at least the past 12 months were included. Anthropometric and biochemical measurements were performed. cIMT and EATT were measured by echocardiography and compared between the patient and control groups.
Results: Body mass index (17.4±3.0 vs. 18.4±3.1 kg/m2), blood pressure (systolic: 100 (85-120) vs. 100 (80-100) mmHg; diastolic: 60 (40-90) vs. 70 (40-90) mmHg), and lipid profile (total cholesterol: 144.6±30.2 vs. 150.8±22.6 mg/dL; triglycerides: 71.5 (27-178) vs. 92.5 (34-203) mg/dL) were not different between the patient and control groups, while there were significant differences in cIMT and EATT. The patient group had higher cIMT (0.50±0.07 vs. 0.45±0.04 mm) and EATT (5.68±0.90 vs. 4.22±0.76 mm) than the control group. The risk of vitamin D insufficiency was 2.68 times higher in the patient group (95% CI=1.19-6.03).
Conclusions: Children with Celiac disease had higher cIMT and EATT than healthy peers. cIMT and/or EATT measurements by echocardiography may present as a reliable and easy method to investigate subclinical atherosclerosis in children with Celiac disease.
Digital university: Approaches to the concept definition
Authors: Bannykh G. A. , Kostina S. N. 
Published: December 2022

Introduction. The modern period of development of higher education is directly related to the ongoing digital transformation of public relations. The changes that occur in universities, in their external interactions and functions, basic principles and value-normative foundations, require methodological analysis and research.Aim. The aim of the research is to analyse the theoretical approaches to disclosing the concept and essence of digital universities.Methodology and research methods. The mix-method was used as a research design: qualitative analysis (studying the content of theoretical sources and context, analysing the content of a concept) and quantitative analysis (scientometric analysis of publications and keywords in databases).Results. The study showed that in the methodological terms, there is a problem of defining the concept of “digital university”: there are several theoretical approaches based on different understanding of the phenomenon and its role in the digital development of the university. The methodological problem is complicated by the urgent need to systematise the practical activities of modern universities, which classify themselves in one way or another in the “digital” format; therefore, this is much more difficult to do without a coordinated approach to the concept itself.Scientific novelty lies in an attempt to systematise theoretical approaches to defining the concept of “digital university” and the problem of the absence of a holistic interdisciplinary approach has been identified.Practical significance of the study is associated with the need to develop a regulatory model of a digital university based on a holistic concept for the subsequent analysis of the activities of universities. The results of the analysis can be used in scientific discussion to further define the concept of “digital university” and develop a general model of a digital university.
Characteristics of school well-being and anxiety in adolescents with disabilities
Authors: Shamionov R. M. , Grigorieva M. V. , Grinina E. S. , Sozonnik A. V. 
Published: December 2022

Introduction.The study of the problem of school well-being and anxiety of adolescents with and without disabilities is of fundamental importance for the psychological support of the process of academic adaptation.Aim.The present researchaimedto conduct a comparative analysis of the characteristics of school well-being and school anxiety as the main indicators of academic adaptation of young adolescent schoolchildren with disabilities.Methodology and research methods.The authors used a questionnaire aimed at identifying the main demographic indicators; the Phillips test aimed at assessing the main indicators of school anxiety: general anxiety, social stress, frustration of success, fear of self-expression, fear of testing knowledge, fear of not meeting expectations, low resistance to stress, problems in relationships with teachers; original scales for assessing indicators of school well-being, including the areas of relationships with classmates and teachers, self-assessment of educational activities, educational motivation, self-regulation of emotional states. The use of the subject approach in the study allowed the authors to identify the subject (emotional-regulatory) factors of school well-being and to determine the ways of psychological support for the academic adaptation of adolescents with disabilities. The study involved 120 primary young adolescent schoolchildren (46.7% girls, 53.3% boys) enrolled in general education schools and in schools that offer adaptive learning programmes.Results.The authors found out that well-being indicators, which characterise interpersonal relationships, satisfaction with learning, and motivation for achievements, unpleasant physical sensations, are higher in adolescents with disabilities. The ability to be insistive and to have a differentiated attitude to lessons is an external negative motivation for learning in relatively healthy adolescents. Higher indicators of school anxiety of relatively healthy students reflect increased psychological tension in the conditions of general education schools and there is the need for special organisational and content changes in schools to create a real inclusive environment. The confirmatory model of school well-being indicators reflects three important aspects of it: “Self-organisation based on reflection”, “Ability to emotional self-regulation” and “Positive school motivation”.Practical significanceof the current research lies in the possibility of using its results to optimise the process of academic adaptation of adolescents and to specify the principles of inclusive education in accordance with the specifics of adolescents’ school well-being and school anxiety.
Development of Interactive Learning Media Kersosmi Bunisa Social Science Class IV Elementary School
Authors: Nandawika Itvianoke Jihan , Murti Tri , Mas'ula Siti 
Published: December 2022

Abstrak:Â Tujuan penelitian dan pengembangan ini yaitu menghasilkan media pembelajaran interaktif Kersosmi Bunisa (Keragaman Sosial, Ekonomi, Budaya, Etnis, dan Agama) aplikasi android yang valid menurut ahli materi, ahli media, dan guru, serta praktis menurut peserta didik. Model penelitian dan pengembangannya menggunakan R&D oleh Borg dan Gall dengan tahapan potensi dan masalah, pengumpulan data, desain produk, validasi produk, revisi produk, uji coba produk, revisi produk, uji coba pemakaian, revisi produk, danÂ produksi massal. Hasil dari ahli materi sebesar 91,7 persen, ahli media sebesar 87,5 persen, dan guru sebesar 92,8 persen. Semuanya dengan kriteria sangat valid dan dapat digunakan tanpa revisi. Hasil angket respons peserta didik tentang kepraktisan pada uji coba produk skala kecil sebesar 100 persen dan uji coba pemakaian skala besar sebesar 94,2 persen dengan kriteria sangat praktis dan dapat digunakan tanpa revisi.Media pembelajaran interaktif Kersosmi Bunisa direkomendasikan untuk meningkatkan minat belajar siswa, menunjang efektivitas, efisiensi, dan peningkatan mutu pembelajaran IPS kelas IV.Abstract:Â The goal of this research and development was to create Android applications for Kersosmi Bunisa (Social, Economic, Cultural, Ethnic, and Religious Diversity) that are valid in the eyes of material experts, media experts, and teachers, as well as practical in the eyes of students. Potential and difficulties, data collecting, product design, product validation, product revision, product testing, product revision, user trial, product revision, and mass manufacturing are all steps in the Borg and Gall research and development paradigm. Material specialists scored 91.7 percent, media experts scored 87.5 percent, and educators scored 92.8 percent. These belong to very valid criterion and can be employed without revision. The findings of the student response questionnaire on practicality in small-scale product testing were 100 percent, and large-scale usage trials were 94.2 percent, which means very practical and may be used without revision. Kersosmi Bunisa interactive learning media is recommended for class IV social studies learning to boost student interest in learning, support effectiveness, efficiency, and improve quality.
Estudio comparativo de los diferentes acondicionamientos de superficie sobre las propiedades de flexión y análisis topográfico de los postes de fibra de vidrio.
Authors: Ortega Condori Myriam Rosmery , Llerena Pérez Lourdes Concepción , León Manco Roberto Antonio 
Published: December 2022

Objetivo: Evaluar las propiedades de flexión y topografía de los postes de fibra tratados superficialmente. Material y Métodos: Experimental, In vitro. Las muestras fueron divididas en dos grupos, se evaluó la flexibilidad de 40 postes de fibra de vidrio de 2 casas comerciales para cada procedimiento de acondicionamiento P1: FGM White Post DC; P2: MAQUIRA Fiber Post. Las técnicas de acondicionamiento fueron: T1: control T2: Ácido Fluorhídrico 10% 15 segundos T3: Peróxido de Hidrógeno 24% 60 segundos T4: oxido de aluminio 50 µm y se sometieron a la máquina universal de ensayos, para la prueba de flexión de 3 puntos. Se observó la superficie topográfica de los postes de fibra de vidrio utilizando un microscopio electrónico de barrido. Resultados: La deflexión (mm) se evidenció diferencia significativa comparando los grupos control y los grupos acondicionados con un valor máximo promedio de 0,59mm ±0.04 y un valor mínimo de 0,51mm ±0,06. En la fuerza máxima (N) se evidenció diferencia significativa comparando los grupos control y los grupos acondicionados, con un valor máximo de 133.68 ±11.42 N y un valor mínimo de 103.48 ±17.79 N. Conclusiones: No se encontró efectos adversos sobre las propiedades de flexión para ambos grupos de postes de fibra de vidrio después del acondicionamiento de superficie con los diferentes protocolos.