bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Environmental and Socioeconomic Effects and Forecast of Tuberculosis Patients in the Southwest of China: a population-based study
Authors: Wei Wen , Xia Lan , Wu Jianlin , Zhang Wenqiang , Zhou Zonglei , Luan Rongsheng 
Published: July 2022

Abstract
Background To assess the incidence of tuberculosis in the population and find the risk factors and forecast of tuberculosis patients with a high burden of tuberculosis (TB) in socioeconomic level.Methods Descriptive analysis, Spatial and Space-Time Scan, Correlation analysis and regression analysis were carried out, based on cases of TB in Sichuan Province and ecological data from 2006 to 2017, to explore the characters of TB and ecological factors, using transfer function noise model to forecast the trend of TB until 2035(by SPSS 20.0 , SatScan v9.5, ArcGis 10.2 software ).Results 783,735 tuberculosis cases were reported in Sichuan Province, during 2006 to 2017. Linshui County was the aggregation center, the aggregation radius was 237.17 Km, and the aggregation time was from 2006 to 2011. Factors affecting the incidence of TB, increasing per capita green area, reporting status of TB among Tibetans and Yi minorities, comprehensive treatment management, total cost of tuberculosis per capita for urban residents, proportion of males with high school education, 20 to 20 hours of 24-hour accumulated precipitation, reducing HIV at the same time as AIDS deaths, the increase in the proportion of males in junior high school education and the increase in the number of registered tuberculosis cases can reduce the incidence of TB. The incidence of TB in the whole population aged 15-24 and aged 25-64 owning a increase trend by 2035.Conclusion Enhanced control of the environment, education, medical and health, population structure, marital status could control incidence of TB. Reinforcement required to reduce the TB of east Sichuan Counties and the incidence of TB in the whole population aged 15-24 and aged 25-64 in socioeconomic level by 2035.
Comparison of Cardiac Index Measurements in Intensive Care Patients using Continuous Wave versus Pulsed Wave Echo-Doppler compared to Pulse Contour Cardiac Output
Authors: Parulekar Prashant , Powys-Lybbe James , Bassett Paul , Roques Seb , Snazelle Mark , Harris Tim 
Published: July 2022

Abstract
Purpose:Cardiac index (CI) assessments are commonly used in critical care to define shock aetiology and guide resuscitation. Echocardiographic assessment is non-invasive and has high levels of agreement with thermodilution assessment of CI. CI assessment is derived from the velocity time integral (VTI) assessed using pulsed wave (PW) doppler at the level of the left ventricular outflow tract (LVOT) divided by body mass index (BMI). Continuous wave (CW) doppler offers an alternative means to assess VTI and may offer better assessment at high velocities. Methods:We performed a single centre, prospective, observational study in a 15-bed intensive care unit (ICU) in a busy district general hospital. Patients had simultaneous measurements of cardiac index by Pulse Contour Cardiac Output (PiCCO) (thermodilution), transthoracic (TTE) LVOT PW-VTI and TTE AV CW-VTI. Mean differences were measured with Bland-Altman (B-A) limits of agreement (LOA) and Percentage Error (PE) calculations.Results:Data was collected on 52 patients. Mean CIs were: AV CW 2.7 L/min/m2 (range 0.78 – 5.11, SD 0.92). LVOT PW 2.33 L/min/m2 (range 0.77 – 5.40, SD 0.90) and PiCCO 2.86 L/min/m2 (range 1.50 – 5.56, SD 0.93). AV CW VTI and PiCCO mean difference was -0.16 L/min/m2 PE 43.5%. LVOT PW VTI and PiCCO had a mean difference of -0.54 L/min/m2 PE 38.6%. AV CW VTI and LVOT PW VTI had a mean difference of 0.38 L/min/m2 PE 46.0%. Conclusions:CI derived from both AV CW-VTI and LVOT PW-VTI methods underestimate CI compared to PiCCO, with the AV method having closer values overall to PiCCO. AV CW-VTI may offer a more accurate assessment of CI.
Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development
Authors: Zhang Guo-wei , Cao Rong-chang , Yang Wan-jun , Xiao Wang , Zhang Xiao-lou , Xu Hao , Wang Meng , Zhou Zhitao , Chen Huoji , Xu Jia , Chen Xuemei , Zeng Jun-ling , Li Shu-ji , Luo Min , Han Yan-jiang , Yang Xiao-bing , Feng Guo-dong , Lu Yu-heng , Ni Yuan-yuan , Wu Chan-gui , Bai Jun-jie , Yuan Zi-qi , Jin Jin 
Published: July 2022

Abstract
Background
Noninflammatory clearance of dying cells by professional phagocytes, termed efferocytosis, is fundamental in both homeostasis and inflammatory fibrosis disease but has not been confirmed to occur in chronic pancreatitis (CP). Here, we investigated whether efferocytosis constitutes a novel regulatory target in CP and its mechanisms.
Methods
PRSS1 transgenic (PRSS1Tg) mice were treated with caerulein to mimic CP development. Sphingomyelin metabolite profiling and epigenetic assays were performed with PRSS1Tg CP models. The potential functions of Atp8b1 in CP model were clarified using Atp8b1-overexpressing adeno-associated virus, immunofluorescence, enzyme-linked immunosorbent assay(ELISA) and lipid metabolomic approaches. ATAC-seq combined with RNA-seq was then used to identify transcription factors binding to the Atp8b1 promoter, and ChIP-qPCR and luciferase assays were used to confirm that the identified transcription factor bound to the Atp8b1 promoter, and to identify the specific binding site. Flow cytometry was performed to analysis proportion of pancreatic macrophages.
Results
Decreased efferocytosis with aggravated inflammation was identified in CP. The lysophosphatidylcholine (LPC) pathway was the most obviously dysregulated sphingomyelin pathway, and LPC and Atp8b1 expression gradually decreased during CP development. H3K27me3 ChIP-seq showed that increased Atp8b1 promoter methylation led to transcriptional inhibition. Atp8b1 complementation substantially increased the LPC concentration and improved CP outcomes. Bhlha15 was identified as a transcription factor that binds to the Atp8b1 promoter and regulate sphingomyelin metabolism.
Conclusion
The acinar Atp8b1/LPC pathway acts as an important “find-me” signal for macrophages and plays a protective role in CP, with Atp8b1 transcription promoted by the acinar cell-specific transcription factor Bhlha15. Bhlha15, Atp8b1 and LPC could be clinically translated into valuable therapeutic targets to overcome the limitations of current CP therapies.
Surgeon's detection of lung nodules with intraoperative ultrasound during thoracoscopic surgery: experience of a single centre.
Authors: Messina Gaetana , Bove Mary , Natale Giovanni , Noro Antonio , Martone Mario , Opromolla Giorgia , Filippo Vincenzo Di , Leone Francesco , Leonardi Beatrice , Panini Francesco , Pirozzi Mario , Caterino Marianna , Facchini Sergio , Zotta Alessia , Polito Rita , Vicidomini Giovanni , Santini Mario , Fiorelli Alfonso , Ciardiello Fortunato , Fasano Morena 
Published: July 2022

Abstract
OBJECTIVEVideo-Assisted Thoracic Surgery (VATS) resection, of deep-seated and nodules smaller than 3 cm, is very hard.Solitary, small and deep-seated pulmonary nodules are difficult to palpate or to see during VATS. We aimed to evaluated the validity of Intraoperative lung ultrasound (ILU) to visualize solitary and deep-seated pulmonary nodules smaller than 3 cm to enhance knowledge on the ultrasound morphological patterns.RESULTSUS processor was inserted by expert ultrasound surgeon into the chest through the operating hole, and the mediastinal, costal and diaphragmatic surfaces of the lung were explored.VATS- Ultrasound (VATS-US) allows to identify size, localization and Ultrasound (US) pattern of the lesions of interest.Accuracy of Intraoperative Lung Ultrasound for the detection of pulmonary nodules was calculated-comparing the two groups; the first group in which the patients did not undergo intraoperative ultrasound and the second group in which the patients underwent intraoperative ultrasound.Student's t-test (p<0,0001) showed that the accuracy of intraoperative ultrasound by comparing detection time of nodules in the two groups.Intracavitary VATS-US is a reliable, feasible, real-time and effective method of localization of parenchymal lung nodules during selected wedge resection procedures.
A Qualitative Exploration of the Fear of Recurrence Experienced by the Partners of Breast Cancer Survivors
Authors: Brown Elli , Hoskin Jake , Gullifer Judith 
Published: July 2022

Abstract
Purpose: The current study aimed to qualitatively explore the meanings partners place on fear of cancer recurrence to provide further insight into this phenomenon. Methods: Semi-structured interviews were conducted with eight male partners of breast cancer survivors, aged 50 years or older. The interviews were audio-recorded, transcribed, and then analysed through an inductive thematic analysis.Results: Four general themes were constructed from the data: shared experience, external reminders, facing death and living life, and refrain from worry. The findings highlight the partners’ perception of sharing the cancer journey with the survivor. Thus, the partners’ fear of cancer recurrence was perpetuated by cancer-related reminders, which induced a fear of the survivors’ death and a subsequent endeavor to live a fulfilling life. Regardless, when faced with their fear of cancer recurrence, the partners avoided thinking or worrying about the possibility of a cancer recurrence.Conclusion: These results will provide a conceptual framework for future research to develop and test interventions targeted towards the fear of cancer recurrence experienced by the partners of breast cancer survivors.
Study on fuel/air mixing based on oblique detonation engine
Authors: Xiang Gaoxiang , Li Danyang , Xie Xu Zhen , Tu Qirong , Zhang Yi Chen , Jin Ke 
Published: July 2022

Abstract
Currently, the inflow conditions used in the study of oblique detonation engines are ideal premixed inflow, and there are few studies on non-premixed inflow. The fuel mixing process in the flow field structure and mixing degree for forming oblique blast waves has essential significance. This paper uses a combination of theoretical analysis and numerical simulation to study the inlet section of the oblique detonation engine. The governing equations are the inviscid Euler equations coupled with chemical reaction source terms, and the second-order TVD scheme is used to solve the equations. First, this paper compared the influence of the single hydrogen nozzle parameters on the flow field structure and the hydrogen mole fraction distribution at the outlet, optimized the hydrogen jet structure, and analyzed the coupling effect between the incoming flow and the jet. The closer the nozzle location is to the supersonic inlet, the lower the Mach number, and the higher the equivalence ratio of hydrogen to oxygen, the better the fuel and air mixing effect. And too large or too small hydrogen injection angle will make the hydrogen too concentrated on the wall and insufficient penetration depth, which reduces the mixing of hydrogen. Secondly, while maintaining the same fuel mass flow rate as the single hydrogen nozzle, this paper increases the number of hydrogen nozzles, thereby increasing the obstruction to the incoming flow and improving the fuel mixing effect. Finally, because the physical ramp and aerodynamic ramp as a method of increasing mixing will lead to fuel concentration on the wall, which is not conducive to the subsequent combustion, this paper proposes an optimization model of the strut injection method. The results show that strut injection can effectively improve the mixing degree of hydrogen and air at the exit and solve the problem of fuel concentration at the wall by using the staggered jet and baroclinic effect of hydrogen. This paper reveals the law of fuel injection in the inlet and provides essential data support for studying oblique detonation engines in a non-premixed environment.
Protistan epibionts affect prey selectivity patterns and vulnerability to predation in a cyclopoid copepod
Authors: Kumar Ram , Kumari Suman , Malika Anshu , Sharma A. P. , Dahms Hans-Uwe 
Published: July 2022

Abstract
Colonisation of crustacean zooplankton with ciliate epibionts is widespread in freshwater and marine environments. However, the ecology of such association are little studied as yet. The occurrence of ciliate epibionts on copepods and the preference towards this association with different life stages of Mesocyclops were studied from winter to spring. Relative susceptibility of zooplankton species was evaluated by analysing the epibiont colonies and zooids and relate this to the surface area of the host. The maximum epibiont infestation was recorded on copepodites followed by copepod adults rather than other zooplankton species, whereas the rotifer Asplanchna was never affected. Influence of climatic factors such as temperature on the colonisation of epibionts on basibionts was found significant. In winter (November to February) samples, copepods were infested by autotrophic epibionts whereas in late spring and early summer (March-April) heterotrophic protists (peritrichian ciliates) were the sole epibionts on copepods. We conducted experiments in the laboratory on prey selection pattern of predator by direct visual and video-graphic observations of various events (encounter, attack, capture, ingestion, prey escape) during predation by the infested and uninfested copepodites and adults of Mesocyclops. Postencounter the attack probability was significantly lower in infested than in uninfested copepods. The present paper reports on substrate preference by epibionts and their impacts in food rich and food scarce environments. Further studied on major environmental interactions with the reproductive phenology of copepods with respect to epibionts and the cause and effect of long term association of epibionts with copepods need to be addressed.
Antispasmodic activity of novel 2,4-dichloroanilinium perchlorate hybrid material (I): X-ray crystallography, DFT studies, and molecular docking approach
Authors: Jaziri Emna , Louis Hitler , Gharbi Chaima , Unimuke Tomsmith O. , Agwamba Ernest C. , Mathias Gideon E. , Fugita Wataru , Nasr Chérif Ben , Khedhiri Lamia 
Published: July 2022

Abstract
The intriguing properties of organic-inorganic hybrid materials has resulted in the recent upsurge for more effective hybrid materials with diverse activity, harnessing the advantage of the flexibility and structural diversity imposed by these materials. In line with these, the synthesis, crystallography and structural characterization of a novel perchlorate (2,4-dichloroanilinium perchlorate) organic-inorganic hybrid material is reported. The synthesized structure was characterized by FTIR and NMR techniques. Appropriate computational methods were utilized to correlate the experimentally observed spectroscopic properties as well as other molecular electronic properties. The computational studies were achieved at the DFT/M06-2X/6-311 + + G(2df,2dp) and aug-cc-pVTZ level of theory. For benchmarking purposes, the PWPB95 functional with D3BJ dispersion correction was utilized. Molecular electronic properties such as the frontier molecular orbitals, Natural bond orbital analysis, Hirshfeld surface analysis, and visual study of weak interaction via non-covalent interaction were considered to understand the molecular diversity of the perchlorate cluster. Hybrid materials often pose diverse bio-activities and as such the anti-spasmodic activity of the studied compound is considered by molecular docking approach.
Expression of juvenility related microRNAs and target genes during micropropagation of silver birch (Betula pendula Roth).
Authors: Krivmane Baiba , Girgžde Elva , Samsone Ineta , Ruņģis Dainis Edgars 
Published: July 2022

Abstract
Silver birch (Betula pendula Roth.) is an ecologically and economically important deciduous tree species in Northern Europe. In vitro culture initiation and shoot rejuvenation from birches in their reproductive phase is difficult and often unsuccessful. Currently, markers to evaluate the degree of juvenility of birch in vitro shoots, which could be used to track the rejuvenation process and to determine factors affecting it, have not been developed. The aims of this study were to assess expression of juvenility related microRNAs and target genes during micropropagation of silver birch, and to investigate factors affecting juvenility of birch genotypes with different in vitro morphogenic ability. Potential precursor sequences and target genes of the microRNAs miR156 and miR172 were determined by alignment to the birch unigene set. Ten potential miR156 and miR172 precursor sequences were identified, and were tested for the ability to form the required stem-loop structure. Based on precursor sequences, primers were designed for real time PCR analysis of precursor miRNA expression. Expression patterns of two miR156 family precursors (miR156_511 and miR156_789) and one miR172 precursor (miR172_1931) and two target genes (BpSPL1 and BpAP2) had the best correlation with juvenility/maturity in in vitro propagated silver birch. Expression patterns of these miRNA precursors and target genes were also investigated in samples cultured under different in vitro conditions. This study provides an initial survey of molecular markers for assessment of phase change in birch in vitro micropropagation.
Retrospective study on the efficacy of monocyte distribution width (MDW) as a screening test for COVID-19
Authors: Wakamatsu Kentaro , Nagasawa Zenzo , Katsuki Kouta , Kumazoe Hiroyuki , Yasuda Masayo , Kawamoto Sae , Kawamura Ayano , Ueno Tsuyoshi , Kiyotani Ruriko , Fukui Izumi , Maki Sanae , Nagata Nobuhiko , Kawasaki Masayuki , Yamada Hozumi 
Published: July 2022

Abstract
Background
Pathogenic genetic testing for Coronavirus disease 2019 (COVID-19) can detect viruses with high sensitivity, however there are several challenges. In the prevention, testing, and treatment of COVID-19, more effective, safer, and convenient methods are desired. We evaluated the possibility of monocyte distribution width (MDW) as an infection biomarker in COVID-19 testing.
Methods
The efficacy of MDW as a screening test for COVID-19 was retrospectively assessed in 80 patients in the COVID-19 group and 232 patients in the Non-COVID-19 group (141 patients with acute respiratory infection, 19 patients with non-respiratory infection, 1 patient with viral infection, 11 patients who had received treatment for COVID-19, 1 patient in contact with COVID-19 patients, and 59 patients with non-infectious disease).
Results
The median MDW in 80 patients in the COVID-19 group was 23.3 (17.2–33.6), and the median MDW in 232 patients in the Non-COVID-19 group was 19.0 (13.6–30.2) (P < 0.001). When the COVID-19 group was identified using the MDW cut-off value of 21.3 from the Non-COVID-19 group, the area under the curve (AUC) was 0.844, and the sensitivity and specificity were 81.3% and 78.2%, respectively. Comparison of MDW by severity between the COVID-19 group and patients with acute respiratory infection in the Non-COVID-19 group showed that MDW was significantly higher in the COVID-19 group for all of mild, moderate I, and moderate II disease.
Conclusions
MDW (cut-off value: 21.3) may be used as a screening test for COVID-19 in fever outpatients, etc.
An electrolyte for SiOx/LiNi0.5Mn1.5O4 batteries
Authors: Ko Seongjae , Han Xiao , Shimada Tatau , Takenaka Norio , Yamada Yuki , Yamada Atsuo 
Published: July 2022

Abstract
The Li-ion batteries composed of high-capacity SiOx anode and high-potential LiNi0.5Mn1.5O4 cathode is the most realistic options to meet the increasing demands for higher-energy-density storage systems. However, the absence of electrolytes covering the multifaceted issues from highly reducing and oxidizing conditions at the SiOx anode and LiNi0.5Mn1.5O4 cathode, respectively, has limited its applications. Herein, we present an electrolyte that can solve these issues simultaneously. A concentrated LiN(SO2F)2/methyl (2,2,2-trifluoroethyl) carbonate electrolyte upshifts the reaction potentials of the SiOx anode and enables an earlier formation of a robust anion-derived passivation film upon charge to diminish the reductive degradation of the electrolyte. The weak solvating ability of the electrolyte provides a high oxidation tolerance against Al corrosion and transition metal dissolution from the cathode material. Excellent long-term cycling of 5 V-class SiOx|LiNi0.5Mn1.5O4 full cells (96% capacity retention after 500 cycles at a low constant current of 0.5 C-rate) was achieved.
Enhanced visible-light photocatalytic performance of a novel FeIn2S4 microspheres/BiOBr nanoplates heterojunction with a Z-scheme configuration
Authors: Zhang Biao , Liu Yu , Zhu Hongyu , Gu Dongxu , Zhou Kanghong , Hao Jianyuan 
Published: July 2022

Abstract
The rational design of heterojunction photocatalysts is an effective way to improve semiconductor photocatalytic activity. The simple solvothermal method was used to successfully prepare visible light-driven FeIn2S4 microspheres/BiOBr nanoplates binary heterojunction photocatalysts with varying FeIn2S4 contents. The crystal structure, morphology, surface composition, specific surface area, charge separation and optical properties of the as-prepared photocatalysts were investigated using a variety of analytical methods. In the photocatalytic degradation of rhodamine B, the FeIn2S4/BiOBr photocatalysts obtained a degradation efficiency of 96% within 60 min, which was approximately 5.33 and 2.59 times higher than pure FeIn2S4 and BiOBr, respectively. Radical trapping experiments and ESR measurements revealed the main active species (·OH, ·O2−, and h+) produced during photocatalytic degradation. The increased photocatalytic activity was due to the formation of Z-scheme heterojunctions between FeIn2S4 and BiOBr, which contributed to the improved effective charge separation of photogenerated charge carriers, augmented specific surface area and enhanced redox capacity. It is expected that our current study will provide a hopeful way for future environmental remediation research.
Attribute Based Signature Architecture for Transferring Digital Document
Authors: Panse Trishna , Panse Prashant 
Published: July 2022

Abstract
Authentication and cryptosystems are two examples of methods for ensuring user identification and data confidentiality. Because of its one-way nature, hashing is used to verify the identity and accuracy of data travelling across an open medium. It detects unlawful modifications and changes made to transmissions. Digital signature, which deals with document uniqueness and creator oneness, are a well-known application of hashing. It is updated by adding more information about the users' attributes and is classified as an attribute-based signature (ABS). We investigated various past approaches to the ABS phenomena and discovered certain unsolved challenges, resulting in a solution that decreases the difficulty level, utilization, and operating expense coupled with signature creation and confirmation. For focusing the method of digital signatures using elements and their first order logic, we suggested a unique Attribute Based Signature Architecture for Transferring Digital Document. The system includes flexible primitives that give signing parties complete control over signature generation as well as policy-based access security constraints. It has a message-based first order logic and protects the secrecy of signatures. After examining the technique logically, various benefits were discovered, which will be confirmed soon by the implementation solution over the recommended framework under the specified key.