bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship Between Preexisting Functional Mobility Impairments and Burn Treatment Outcomes
Authors: Smith Susan , Seoane Jacqueline , Emerson Lisa , Rainey Andrew , Smith Howard G 
Published: June 2022

Abstract
Burn severity is determined by total body surface area affected, temperature of source, and duration of exposure. Patients with impaired mobility are less capable of avoiding hazards and escaping traumatic injuries. Additionally, patients with impaired mobility frequently suffer from other comorbid conditions and have specialized needs, which can complicate their acute treatment. This study was a retrospective electronic medical records review of all adult patients, aged 18 years and older with a preexisting mobility impairment, admitted as inpatients to a single burn center for treatment of burn-related injuries from January 1, 2009, to December 31, 2019. The 10-year review of 1520 adult burn admissions meeting the initial criteria of inpatient admission and burn injury revealed 174 patients with documentation supporting preexisting functional mobility impairment (11%). Surprisingly, patients’ overall lengths of stays were consistent with all burn populations at 0.81 days per % TBSA, with the average length of stay being 6.7 days. The demographic data were consistent with national burn registry data as male, Caucasian, and older, with mean age of 61.1 years. Demographic data and details of hospital course focusing on treatment, complications, and outcomes were extracted and analyzed. There is a paucity of literature describing the needs of this unique burn population. Burn-injured patients with preexisting mobility impairments suffer from similar mechanisms of injury. By identifying attributes unique to this population, we hope to develop specialized prevention education and treatment protocols.
Long-term dam behavior prediction with deep learning on graphs
Authors: He Peng , Pan Jianbo , Li Yueyang 
Published: June 2022

Abstract
Dam displacement prediction is one of the most crucial considerations for ensuring the dam’s long-term safe operation. Most existing models focus on predicting individual displacement and ignore the spatial and temporal correlation of data. To address these issues, a novel prediction model based on attention mechanism and graph convolutional network is proposed. To extract the spatial and temporal correlation of the original data, the position embedding and aggregation modules are employed in the prediction model. Through the aggregation module, a spatial-temporal graph is constructed. The spatial-temporal chart connects spatial diagrams of different time steps together. To capture the spatial-temporal features in the constructed graph, a recurrent graph convolutional module is employed. Through the recurrent graph convolutional module, the spatial-temporal features are used to predict the dam displacement. For verification, an arch dam is taken as an example. Comparing eight baseline models, the proposed model is more effective than other prediction models. Therefore, the proposed model can be adapted for engineering applications.
Extremely Low mtDNA Diversity and High Genetic Differentiation Reveal the Precarious Genetic Status of Dugongs in New Caledonia, South Pacific
Authors: Garrigue Claire , Bonneville Claire Daisy , Cleguer Christophe , Oremus Marc 
Published: June 2022

AbstractNew Caledonia is home to one of the largest remaining populations of dugongs (Dugong dugon) and is located at the southeastern limit of the species range. Local knowledge suggests that current levels of removal due to anthropogenic pressures are unsustainable, whereas trends suggest an ongoing decline in the population. Considering this unfavorable conservation context, this study aimed to assess the New Caledonian dugong population’s resilience by determining its level of genetic diversity and degree of isolation relative to other populations. Mitochondrial DNA (mtDNA) control region sequences (n = 55) collected from live and dead dugongs in New Caledonia were compared with a global data set of previously published sequences (n = 631) representing dugong populations throughout the species range. The New Caledonian dugong population displayed the lowest level of mtDNA diversity documented worldwide (3 haplotypes with 1-bp difference), suggesting a recent origin of the current population through limited colonization events. Population structure analyses indicate a strong genetic differentiation with all the putative populations represented in the global data set, including large neighboring Australian populations. These results show that the dugong population in New Caledonia is particularly isolated, fragile, and vulnerable to anthropogenic threats and diseases with low potential for resilience through incoming gene flow. Our findings call for an instant conservation response and consideration for IUCN population assessment to support the long-term survival of the New Caledonian dugong population.
A multianalyte assay for the detection of dermatomyositis-related autoantibodies based on immunoprecipitation combined with immunoblotting
Authors: Kuwana Masataka , Okazaki Yuka 
Published: June 2022

ABSTRACT

Objective
To develop a multianalyte assay for the detection of dermatomyositis (DM)-related autoantibodies using immunoprecipitation (IP) combined with immunoblotting (IB).

Methods
Sera from 116 DM patients were subjected to RNA and protein immunoprecipitation assays as well as commercial enzyme-linked immunosorbent assays (ELISAs) for anti-aminoacyl transfer RNA synthetase, anti-melanoma differentiation antigen 5 (MDA5), anti-Mi-2, anti-transcriptional intermediary factor-1γ (TIF-1γ), and anti-U1 ribonucleoprotein antibodies. The IP/IB assay was developed by immunoprecipitation of autoantigens from HeLa cell extracts using patient sera, followed by immunoblotting with an antibody against Mi-2, TIF-1γ, OJ, nuclear matrix protein (NXP)-2, MDA5, PM/Scl, small ubiquitin-like modifier activating enzyme (SAE), or Ku. A multianalyte assay was designed by mixing primary antibodies in the IP/IB assay.

Results
IP assays identified any DM-related autoantibodies in 100 patients (86%), of which 82% were covered by commercial ELISAs, with a false-positive result in two sera and a false-negative result in one serum. The results obtained from the multianalyte IP/IB assay and ‘gold-standard’ IP assays were concordant in terms of the presence or absence of anti-MDA5, anti-TIF-1γ, anti-OJ, anti-NXP-2, anti-PM/Scl, anti-SAE, anti-Mi-2, and anti-Ku antibodies.

Conclusion
This multianalyte IP/IB assay combined with commercial ELISAs is an alternative to ‘gold-standard’ IP assays for the detection of DM-related autoantibodies.
Modified Boyes’ procedure for the multiple finger extensor tendon ruptures in patients with rheumatoid arthritis: A report of two cases
Authors: Kondo Naoki , Kanai Tomotake , Yamada Kazuya , Sakazume Yusuke , Tabata Satoshi , Ikarashi Fumie , Takano Mayuko , Watanabe Takahiro , Kakutani Rika , Kijima Yasufumi , Kawashima Hiroyuki , Ishikawa Hajime 
Published: June 2022

ABSTRACT
Multiple subcutaneous extensor tendon ruptures in more than the ulnar three fingers sometimes occur in patients with rheumatoid arthritis accompanied by wrist deformity. In these situations, the flexor digitorum superficialis tendon of the middle finger (the FDS3 tendon) and that of the ring finger (the FDS4 tendon) are used for the transferred tendon (modified Boyes’ procedure). Here, we treated two patients with rheumatoid arthritis, whose extensor tendons of more than three fingers were ruptured, using the modified Boyes’ procedure. Case 1 had ruptures in four fingers (index through little), and Case 2 had ruptures in three fingers (middle through little). The FDS3 and FDS4 tendons were passed subcutaneously around the radial side of the wrist to the extensor sides and interlaced with the distal stump of the ruptured tendons. Switching of the finger movement was achieved smoothly in both cases. The post-operative evaluation showed an extension lag of −15° for the index finger 0° for the middle through the little fingers in Case 1, and 0° for the middle finger and −5° for the ring and little fingers in Case 2. The average post-operative extension lag was −3.5°. However, median nerve palsy occurred in both cases, and it gradually recovered. Stretching of the nerve by the correction of the wrist deformity and increased pressure in the carpal tunnel were supposed to be causes of this palsy. Modified Boyes’ procedure is a useful method for more than three ulnar finger extensor tendon ruptures; however, post-operative median nerve palsy should be considered.
Thermal Budgets of Magma Storage Constrained by Diffusion Chronometry: the Cerro Galán Ignimbrite
Authors: Lubbers Jordan , Kent Adam J R , de Silva Shanaka 
Published: June 2022

Abstract
The long-term thermochemical conditions at which large bodies of silicic magma are stored in the crust is integral to our understanding of the timing, frequency, and intensity of volcanic eruptions and provides important context for interpreting volcano monitoring data. Despite this, however, individual magmatic systems may exhibit a range of time–temperature paths, or thermal histories, that are the result of many complex and, in some cases, competing processes. This complexity contributes to an incomplete understanding of the long-term thermal evolution of magma stored within the Earth’s crust. Of recent interest to the volcanology community is the length of time large volumes of rheologically eruptible and geophysically detectable magma exist within the crust prior to their eruption. Here we use a combination of diffusion chronometry, trace element, and thermodynamic modeling to quantify the long-term thermal evolution of the 2.08 Ma, 630 km3 Cerro Galán Ignimbrite (CGI) in NW Argentina; one of the largest explosive volcanic eruptions in the recent geologic record. We find that diffusion of both Mg and Sr in plagioclase indicate that erupted magmatic material only spent decades to centuries at or above temperatures (~750°C) required to maintain significant volumes of stored eruptible magma. Calculated plagioclase equilibrium compositions reveal an array of liquids that is controlled overall by fractionation of plagioclase + biotite + sanidine, although high-resolution trace element transects record a diversity of fractionation pathways. Overall, we suggest that there is compelling evidence that the magma erupted from the CGI magmatic system spent most of its upper crustal residence in a largely uneruptible state and was rapidly remobilized shortly before eruption.
Solutal-buoyancy-driven intertwining and rotation of patterned elastic sheets
Authors: Manna Raj Kumar , Shklyaev Oleg E , Stone Howard A , Balazs Anna C 
Published: June 2022

AbstractThe intertwining of strands into 3D spirals is ubiquitous in biology, enabling functions from information storage to maintenance of cell structure and directed locomotion. In synthetic systems, entwined fibers can provide superior mechanical properties and act as artificial muscle or structural reinforcements. Unlike structures in nature, the entwinement of synthetic materials typically requires application of an external stimulus, such as mechanical actuation, light, or a magnetic field. Herein, we use computational modeling to design microscale sheets that mimic biology by transducing chemical energy into mechanical action, and thereby self-organize and interlink into 3D spirals, which spontaneously rotate. These flexible sheets are immersed in a fluid-filled microchamber that encompasses an immobilized patch of catalysts on the bottom wall. The sheets themselves can be passive or active (coated with catalyst). Catalytic reactions in the solution generate products that occupy different volumes than the reactants. The resulting density variations exert a force on the fluid (solutal buoyancy force) that causes motion, which in turn drives the interlinking and collective swirling of the sheets. The individual sheets do not rotate; rotation only occurs when the sheets are interlinked. This level of autonomous, coordinated 3D structural organization, intertwining, and rotation is unexpected in synthetic materials systems operating without external controls. Using physical arguments, we identify dimensionless ratios that are useful in scaling these ideas to other systems. These findings are valuable for creating materials that act as “machines”, and directing soft matter to undergo self-sustained, multistep assembly that is governed by intrinsic chemical reactions.
Excess natural-cause deaths in California by cause and setting: March 2020 through February 2021
Authors: Chen Yea-Hung , Stokes Andrew C , Aschmann Hélène E , Chen Ruijia , DeVost Shelley , Kiang Mathew V , Koliwad Suneil , Riley Alicia R , Glymour M Maria , Bibbins-Domingo Kirsten 
Published: June 2022

Abstract
Excess mortality has exceeded reported deaths from Covid-19 during the pandemic. This gap may be attributable to deaths that occurred among individuals with undiagnosed Covid-19 infections or indirect consequences of the pandemic response such as interruptions in medical care; distinguishing these possibilities has implications for public health responses. In the present study, we examined patterns of excess mortality over time and by setting (in-hospital or out-of-hospital) and cause of death using death certificate data from California. The estimated number of excess natural-cause deaths from 2020 March 1 to 2021 February 28 (69,182) exceeded the number of Covid-19 diagnosed deaths (53,667) by 29%. Nearly half, 47.4% (32,775), of excess natural-cause deaths occurred out of the hospital, where only 28.6% (9,366) of excess mortality was attributed to Covid-19. Over time, increases or decreases in excess natural non-Covid-19 mortality closely mirrored increases or decreases in Covid-19 mortality. The time series were positively correlated in out-of-hospital settings, particularly at time lags when excess natural-cause deaths preceded reported Covid-19 deaths; for example, when comparing Covid-19 deaths to excess natural-cause deaths in the week prior, the correlation was 0.73. The strong temporal association of reported Covid-19 deaths with excess out-of-hospital deaths from other reported natural-cause causes suggests Covid-19 deaths were undercounted during the first year of the pandemic.
Durability analysis of the highly effective BNT162b2 vaccine against COVID-19
Authors: Puranik Arjun , Lenehan Patrick J , O'Horo John C , Pawlowski Colin , Niesen Michiel J M , Virk Abinash , Swift Melanie D , Kremers Walter , Venkatakrishnan A J , Gordon Joel E , Geyer Holly L , Speicher Leigh Lewis , Soundararajan Venky , Badley Andrew D 
Published: June 2022

Abstract
COVID-19 vaccines are effective, but breakthrough infections have been increasingly reported. We conducted a test-negative case-control study to assess the durability of protection after full vaccination with BNT162b2 against polymerase chain reaction (PCR)-confirmed symptomatic SARS-CoV-2 infection, in a national medical practice from January 2021 through January 2022. We fit conditional logistic regression (CLR) models stratified on residential county and calendar time of testing to assess the association between time elapsed since vaccination and the odds of symptomatic infection or non-COVID-19 hospitalization (negative control), adjusted for several covariates. There were 5,985 symptomatic individuals with a positive test after full vaccination with BNT162b2 (cases) and 32,728 negative tests contributed by 27,753 symptomatic individuals after full vaccination (controls). The adjusted odds of symptomatic infection were higher 250 days after full vaccination versus at the date of full vaccination (Odds Ratio [OR]: 3.62, 95% CI: 2.52 to 5.20). The odds of infection were still lower 285 days after the first BNT162b2 dose as compared to 4 days after the first dose (OR: 0.50, 95% CI: 0.37 to 0.67), when immune protection approximates the unvaccinated status. Low rates of COVID-19 associated hospitalization or death in this cohort precluded analyses of these severe outcomes. The odds of non-COVID-19 associated hospitalization (negative control) decreased with time since vaccination, suggesting a possible underestimation of waning protection by this approach due to confounding factors. In summary, BNT162b2 strongly protected against symptomatic SARS-CoV-2 infection for at least 8 months after full vaccination, but the degree of protection waned significantly over this period.
Development of social feedback processing and responses in childhood: an fMRI test-replication design in two age cohorts
Authors: Dobbelaar Simone , Achterberg Michelle , van Drunen Lina , van Duijvenvoorde Anna c.k , van IJzendoorn Marinus H , Crone Eveline A 
Published: June 2022

Abstract
This study investigated behavioral and neural correlates underlying social feedback processing and subsequent aggressive behaviors in childhood in two age cohorts (test sample: n = 509/n = 385 and replication sample: n = 354/n = 195, 7–9 years old). Using a previously validated Social Network Aggression Task, we showed that negative social feedback resulted in most behavioral aggression, followed by less aggression after neutral and least aggression after positive feedback. Receiving positive and negative social feedback was associated with increased activity in the insula, medial prefrontal cortex and ventrolateral prefrontal cortex. Responding to feedback was associated with additional activation in the dorsolateral prefrontal cortex (DLPFC) following positive feedback. This DLPFC activation correlated negatively with aggression. Furthermore, age analyses showed that older children showed larger reductions in aggression following positive feedback and more neural activation in the DLPFC when responding to positive feedback compared to younger children. To assess the robustness of our results, we examined these processes in two independent behavioral/functional magnetic resonance imaging samples using equivalence testing, thereby contributing to replicable reports. Together, these findings demonstrate an important role of social saliency and regulatory processes where regulation of aggression rapidly develops between the ages of 7 and 9 years.
A need for diet assessment technology for South Asians living in the USA
Authors: Hussain Bridget Murphy , Talegawkar Sameera A , Shivakoti Rupak , Parekh Niyati 
Published: June 2022

AbstractSouth Asians are among the fastest growing ethnic group in the USA yet remain understudied in epidemiologic studies. Due to their unique disease profile, identifying risk moderators and mitigators, such as dietary patterns and food intake, will help to determine the diet–disease relationship that is specific to this largely immigrant population group in the USA. The aim of this commentary is to highlight the dietary traditions and acculturated practices experienced by South Asians in the USA with a call for a diet assessment instrument that adequately captures their dietary diversity. Specifically, we call for (i) the inclusion of traditional food items, such as herbs and spices, that individualize diet assessment for participants; and (ii) leveraging technology that will enhance the experience of diet assessment for both researchers and participants, tailoring the collection of habitual dietary intake in this diverse population group.
Identification and prioritization of key health hazards to workers in roadway construction
Authors: Mo Shicong , Wang Yuhong , Xiong Feng 
Published: June 2022

Abstract
Although various rating systems have been developed to promote sustainable development in roadway construction, sustainability evaluation from the perspective of safeguarding workers’ health is currently lacking. Three approaches were used in the study to identify and prioritize key health hazards to workers in roadway construction, including bibliometric analysis, questionnaire survey and analytic hierarchy process (AHP). Bibliometric analysis indicates that submicron particles and polycyclic aromatic compounds are the primary concerns of researchers, and ergonomics also attracts some attention. A questionnaire survey was conducted among construction workers in China. The results suggest that the most frequently encountered occupational disorders by roadway construction workers are musculoskeletal disorders, heat stroke, respiratory health issues and hearing loss, and the most commonly encountered hazards are noise, dust, asphalt fumes, heat stress and some adverse working conditions. Perceptions on associations between the health hazards and disorders were obtained. Although there are some discrepancies between the AHP scores provided by two groups of professionals in China, the commonly agreed top occupational hazards include dust, asphalt fumes, noise, high-/low-temperature stresses and chronic injuries. The findings may be incorporated into rating systems for roadway construction to encourage the industry to adopt better practices for the well-being of workers.
Coronaviruses in wild animals sampled in and around Wuhan at the beginning of COVID-19 emergence
Authors: Wang Wen , Tian Jun-Hua , Chen Xiao , Hu Rui-Xue , Lin Xian-Dan , Pei Yuan-Yuan , Lv Jia-Xin , Zheng Jiao-Jiao , Dai Fa-Hui , Song Zhi-Gang , Chen Yan-Mei , Zhang Yong-Zhen 
Published: June 2022

Abstract
Over the last several decades, no emerging virus has had a profound impact on the world as the SARS-CoV-2 that emerged at the end of 2019 has done. To know where severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated from and how it jumped into human population, we immediately started a surveillance investigation in wild mammals in and around Wuhan when we determined the agent. Herein, coronaviruses were screened in the lung, liver, and intestinal tissue samples from fifteen raccoon dogs, seven Siberian weasels, three hog badgers, and three Reeves’s muntjacs collected in Wuhan and 334 bats collected around Wuhan. Consequently, eight alphacoronaviruses were identified in raccoon dogs, while nine betacoronaviruses were found in bats. Notably, the newly discovered alphacoronaviruses shared a high whole-genome sequence similarity (97.9 per cent) with the canine coronavirus (CCoV) strain 2020/7 sampled from domestic dog in the UK. Some betacoronaviruses identified here were closely related to previously known bat SARS-CoV-related viruses sampled from Hubei province and its neighbors, while the remaining betacoronaviruses exhibited a close evolutionary relationship with SARS-CoV-related bat viruses in the RdRp gene tree and clustered together with SARS-CoV-2-related bat coronaviruses in the M, N and S gene trees, but with relatively low similarity. Additionally, these newly discovered betacoronaviruses seem unlikely to bind angiotensin-converting enzyme 2 because of the deletions in the two key regions of their receptor-binding motifs. Finally, we did not find SARS-CoV-2 or its progenitor virus in these animal samples. Due to the high circulation of CCoVs in raccoon dogs in Wuhan, more scientific efforts are warranted to better understand their diversity and evolution in China and the possibility of a potential human agent.