bluuebunny/crossref_metadata_2025_split huggingface dataset:
FDA Approval Summary: Oral Azacitidine for Continued Treatment of Adults with Acute Myeloid Leukemia Unable to Complete Intensive Curative Therapy
Authors: Jen Emily Y. , Wang Xin , Li Meng , Li Hongshan , Lee Shwu-Luan , Ni Nina , Przepiorka Donna , Vallejo Jonathon , Leong Ruby , Ma Lian , Gehrke Brenda J. , McLamore Sherita , Theoret Marc R. , de Claro R. Angelo 
Published: March 2022

Abstract
On September 1, 2020, the FDA granted approval for oral azacitidine (Onureg, CC-486) for continued treatment of adult patients with acute myeloid leukemia (AML) who achieved complete remission (CR) or complete remission with incomplete blood count recovery (CRi) following intensive induction chemotherapy and who are not able to complete intensive curative therapy. Approval was based on improvement in overall survival using CC-486 300 mg daily in a 2 weeks on/2 weeks off schedule in comparison with placebo (HR, 0.69; 95% confidence interval, 0.55–0.86; P = 0.0009) in the randomized trial CC-486-AML-001 (QUAZAR) in adults ≥ 55 years old with AML in CR/CRi who did not complete standard intensive induction and postremission therapy. Of note, the study was not designed to test CC-486 as maintenance after standard postremission therapy or as an alternative to standard postremission therapy. Gastrointestinal toxicities, fatigue, and pneumonia were more common in patients treated with CC-486 compared with placebo. Additional studies are needed to establish safe dosing for patients with hepatic impairment. The pharmacokinetic parameters, recommended dose, and recommended schedule of CC-486 differ substantially from those of other azacitidine formulations; therefore, inappropriate substitutions between formulations pose a considerable risk for harm.
“Uma mulher escandalosa”: situações que marcam a construção de identidade
Authors: Sousa Albetania Pessoa de , Ferreira Rejane de Souza 
Published: March 2022

Neste artigo fazemos a análise da identidade de Eily, protagonista do conto “Uma Mulher Escandalosa”, da irlandesa Edna O’Brien. Para isso, iniciamos problematizando os percursos de como se dá a construção da identidade feminina, sob a perspectiva do ponto de vista da narradora. Em seguida, apresentamos como a narrativa em si contribui para a construção da identidade de Eily, destacando três situações que melhor representam a identidade da protagonista. Desse modo, essa análise justifica-se porque a história narrada intercambia experiências sobre mulheres que foram silenciadas e afetadas em sua individualidade por um conjunto de poderes impessoal e atemporal, para os quais suscita espanto e reflexão. A condução teórica da análise literária está composta pelos referenciais de Luís Alberto Brandão Santos e Silvana Pessôa de Oliveira, que apontam como se dá a construção da narrativa, seguidos pelos conceitos sobre o tipo de narrador proposto por Norman Friedman e Yves Reuter. Para a análise identitária trago as abordagens de Kathryn Woodward, Erich Fromm, Jean-Claude Deschamps e Pascal Moliner, além de Michael Foucault, que explica os mecanismos de poder sobre os corpos, e por último, a perspectiva de Judith Butler sobre a identidade de gênero.

*Este artigo é um recorte da pesquisa de dissertação intitulada Mimese da Relação Triádica entre identidade Cultura e Poder em três contos de Edna O’Brien, feita por Albetania Pessoa de Sousa, sob a orientação da Profa. Dra. Rejane de Souza Ferreira.
O corpo angustiado em Niketche: uma história de poligamia, de Paulina Chiziane
Authors: Silva Fernanda Oliveira da , Silva Maria Teresa Salgado Guimarães da 
Published: March 2022

Este artigo apresenta uma leitura do corpo feminino, em Niketche: uma história de poligamia, de Paulina Chiziane. Tal corpo, impulsionado pela angústia, se desloca e entra em contato com diversos espaços, levando-nos a conhecer Moçambique de Norte a Sul. Nesse sentido, buscou-se analisar como as marcas de subalternidade e os estereótipos refletem-se no corpo da protagonista e também discutir o próprio olhar da personagem a respeito de seu corpo, que é influenciado pela cultura e práticas sociais do local em que está inserido. Para tais discussões, utilizaremos O segundo sexo de Simone de Beauvoir, que analisa como o corpo da mulher é moldado desde a infância para ser visto como objeto e como o destino da mulher é ligado ao seu corpo. Cultura e representação de Stuart Hall nos auxiliará na análise dos estereótipos que são impostos aos corpos femininos. O livro Não serei eu mulher?, de bell hooks traz a imagem do corpo negro feminino no período colonial e relata como a mulher negra escravizada teve seu corpo sexualizado e explorado em tantos aspectos.
Same-Sex Marriage Recognition and Taxes: New Evidence about the Impact of Household Taxation
Authors: Friedberg Leora , Isaac Elliott 
Published: March 2022

Abstract
The U.S. income tax code encourages marriage for some and discourages marriage for others, but same-sex couples were only recently exposed to these incentives. We estimate marriage responses by exploiting variation in the recognition of same-sex marriages for tax purposes versus earlier papers leveraging smaller changes. Using the American Community Survey, which reports cohabitation and marriage, we estimate a significant though very small marriage elasticity, with further analysis suggesting a higher (though still small) elasticity for low-earning households and in response to federal taxes specifically. Our estimates imply that the 2018 tax reform will increase marriage among high-earning cohabiting couples.
Economic Distress and Electoral Consequences: Evidence from Appalachia
Authors: Firoozi Daniel 
Published: March 2022

Abstract
Information about inequality can change political attitudes in lab and survey experiments. I use data from the Appalachian Regional Commission and a regression discontinuity design to test whether salient information about local poverty can impact voter behavior in a field setting. I find that when the poorest decile of counties is labeled “economically distressed,” the Democratic share of the Presidential and House popular vote rises in subsequent elections. I present suggestive evidence linking this result to local news coverage, rather than spending or other outcomes.
Police Violence, Student Protests, and Educational Performance
Authors: González Felipe , Prem Mounu 
Published: March 2022

Abstract
We study the protest behavior of teenagers linked to a student killed by a stray bullet coming from a policeman in Chile. We use administrative data to follow the schoolmates of the victim and those living near the shooting on hundreds of protest and nonprotest days. We find that police violence causes lower protest participation in street rallies but more adherence to test boycotts. These effects appear among schoolmates of the victim and not among students living near the killing. Negative educational consequences suffered by the schoolmates combined with previous results suggest that psychological mechanisms are a plausible explanation.
Biases in Information Selection and Processing: Survey Evidence from the Pandemic
Authors: Faia Ester , Fuster Andreas , Pezone Vincenzo , Zafar Basit 
Published: March 2022

Abstract
We conduct two survey experiments to study which information people choose to consume and how it affects their beliefs. In the first experiment, respondents choose between optimistic and pessimistic article headlines related to the COVID-19 pandemic and are then randomly shown one of the articles. Respondents with more pessimistic prior beliefs tend to prefer pessimistic headlines, providing evidence of confirmation bias. Additionally, respondents assigned to the less preferred article discount its information. The second experiment studies the role of partisan views, uncovering strong source dependence: news source revelation further distorts information acquisition, eliminating the role of priors in article choice.
Lactarius&nbsp;indoevosmus and L. kanadii&nbsp; (Russulaceae), two new species from the northwestern Himalayas, India, inferred from morphology and molecular data
Authors: VERMA KOMAL , MEHMOOD TAHIR , UNIYAL PRIYANKA , SHARMA YASH PAL 
Published: March 2022

Two new species of the genus Lactarius from India, Lactarius indoevosmus (L. subg. Lactarius) and L. kanadii (L. subg. Plinthogalus) are presented with detailed descriptions, line drawings, photomicrographs, and comparisons with related species. The novelty and placement of these taxa within the genus Lactarius are confirmed with an ITS-based phylogeny.
Minimally Invasive Surgical Approach to Toxic Colitis
Authors: Moghadamyeghaneh Zhobin , Rahimi Murwarid , Kopatsis Katherine , Kopatsis Anthony Paul , Kopatsis Anthony 
Published: March 2022

Background We aimed to compare outcomes of surgical treatments of toxic colitis (infectious/inflammatory/ischemic) by the extent of colectomy (partial vs total colectomy) and different surgical approaches (minimally invasive surgery (MIS) vs open). Methods Multivariate analysis using logistic regression was used to investigate outcomes of patients with toxic colitis who underwent emergent colectomy during 2012-2019 by surgical approach and the extent of resection using NSQIP database. Results Overall, 2,104 adult patients underwent emergent colectomy for toxic colitis within NSQIP database during 2012-2019. Overall, 1,578 (75.4%) underwent total colectomy with colostomy, 486 (23.2%) underwent partial colectomy with colostomy, and 28 (1.3%) underwent partial colectomy with anastomosis. Overall, 198 (9.4%) of procedures were minimally invasive (MIS) with a 40.1% conversion rate to open. Thirty days mortality and morbidity of the patients were 31 and 86%, respectively. There was no significant difference in mortality of partial colectomy without anastomosis compared to total colectomy ( P = .86) and partial colectomy with anastomosis ( P = .64). Anastomosis was associated with 32.3% anastomosis leakage and 17.9% reoperation. MIS approach was associated with significant decrease in mortality (8.6 vs 33.3%, AOR: .35, P < .01) and morbidity (62.9 vs 87.8%, AOR: .49, P < .01) of patients. Conclusion Patients with toxic colitis undergoing surgical treatment have high mortality and morbidity. An MIS approach when possible is significantly associated with decreased morbidity and mortality of patients. There was no significant difference in outcomes seen when extending the resection in multivariate analysis. Anastomosis is associated with a high anastomosis leakage and need for reoperation risk.
Penetrating foreign body in the larynx presenting as hoarseness
Authors: Lo Sheng-Wei , Yang Tsai-Ni , Tsai Ming-Shao 
Published: March 2022

Penetrating neck injuries are not uncommon, while penetrated foreign bodies involving the larynx are rare, which can be critical and challenging even for experienced physicians. We presented a case of a 64-year-old man with a piece of grinder blade penetrating through the subglottic region, visiting our outpatient department with hoarseness persisting for 3 weeks. The flexible fiberoptic laryngoscope, CT and direct laryngoscope were used to establish the right diagnosis. A cervical incision over the prior scar region was performed to remove the foreign body from the laryngeal box. Clinically, laryngotracheal injuries could lead to severe crisis without proper and prompt treatment. As to penetrated foreign bodies involving the larynx, a proper airway management and surgical approach are crucial for minimizing the morbidity and mortality. An accurate localization and preoperative planning is on the other hand indispensable to a successful removal and recovery.
Outcomes of Adenotonsillectomy for Obstructive Sleep Apnea in Children Under 3 Years of Age
Authors: Rayasam Swathi S. , Abijay Claire , Johnson Romaine , Mitchell Ron B. 
Published: March 2022

Objectives: To identify predictors of obstructive sleep apnea (OSA) after adenotonsillectomy (T&A) in children under 3 years of age and to describe the characteristics of children with OSA under 3 years of age undergoing T&A in an ethnically diverse population. Methods: We examined 87 children under 3 years with T&A and pre- and post-operative polysomnography (PSG) between 8/2012 and 3/2020 at a large tertiary care hospital. Differences were compared for covariates including demographics, comorbidities, and respiratory parameters. Regression was used to identify predictors of persistent severe OSA. Significance was set at P < .05. Results: Of the 87 children in the study, 64 (74%) were male, 26 (30%) were obese, 34 (39%) were Hispanic, and 35 (40%) were Black. Most children (94%) had improvements in OSA severity as measured by the apnea-hypopnea index (AHI) after T&A, but 78% had persistent OSA (AHI ≥1) after surgery. Children with persistent mild, compared to moderate-severe OSA, were more likely to have gastroesophageal reflux disease (GERD) (50% versus 24%, P = .025), a craniofacial disorder (30% versus 10%, P = .025), Down syndrome (20% versus 5%, P = .031), or pre-operative severe OSA. Conclusions: This study of an ethnically diverse population found that T&A is an effective procedure at improving, but not resolving, OSA in children under 3 years. Children with Down syndrome, craniofacial abnormalities, GERD, or pre-operative severe OSA who are under 3 years old are at high risk for persistent OSA and may benefit from post-operative PSG. Future study should examine complications and long-term outcomes of T&A in this age group.
High-intensity versus low-intensity resistance training in patients with knee osteoarthritis: A randomized controlled trial
Authors: de Zwart Arjan H , Dekker Joost , Roorda Leo D , van der Esch Martin , Lips Paul , van Schoor Natasja M , Heijboer Annemiek C , Turkstra Franktien , Gerritsen Martijn , Häkkinen Arja , Bennell Kim , Steultjens Martjin PM , Lems Willem F , van der Leeden Marike 
Published: March 2022

Objectives To assess whether (i) high-intensity resistance training (RT) leads to increased muscle strength compared to low-intensity RT in patients with knee osteoarthritis (OA); and (ii) RT with vitamin D supplementation leads to increased muscle strength compared to placebo in a subgroup with vitamin D deficiency. Design Randomized controlled trial Setting Outpatient rehabilitation centre Subjects Patients with knee OA Interventions 12 weeks of RT at high-intensity RT (70–80% of 1-repetition maximum (1-RM)) or low-intensity RT (40–50% of 1-RM) and 24 weeks of vitamin D (1200 International units vitamin D3 per day) or placebo supplementation. Main measures Primary outcome measure was isokinetic muscle strength. Other outcome measure for muscle strength was the estimated 1-RM. Secondary outcome measures were knee pain and physical functioning. Results 177 participants with a mean age of 67.6 ± 5.8 years were included, of whom 50 had vitamin D deficiency. Isokinetic muscle strength (in Newton metre per kilogram bodyweight) at start, end and 24 weeks after the RT was 0.98 ± 0.40, 1.11 ± 0.40, 1.09 ± 0.42 in the high-intensity group and 1.02 ± 0.41, 1.15 ± 0.42, 1.12 ± 0.40 in the low-intensity group, respectively. No differences were found between the groups, except for the estimated 1-RM in favour of the high-intensity group. In the subgroup with vitamin D deficiency, no difference on isokinetic muscle strength was found between the vitamin D and placebo group. Conclusions High-intensity RT did not result in greater improvements in isokinetic muscle strength, pain and physical functioning compared to low-intensity RT in knee OA, but was well tolerated. Therefore these results suggest that either intensity of resistance training could be utilised in exercise programmes for patients with knee osteoarthritis. No synergistic effect of vitamin D supplementation and RT was found, but this finding was based on underpowered data.
Sustainable institutional investment in the COVID-19 pandemic
Authors: Hoang Lai T , Yang Joey Wenling 
Published: March 2022

This article examines institutions’ investment strategies towards environmental and social (E&S) stocks in the first quarter of 2020, coinciding with the COVID-19 pandemic outbreak. Backed with both institutional- and firm-level analyses, we find that institutional investors shift towards stocks with higher E&S performance. The high E&S portfolios exhibit lower risk and return characteristics, outperforming (underperforming) their peers on market-down (-up) days. Further analysis shows this shift towards E&S is not a permanent transition, rather it reversed with the market rebound in the second quarter, thereby suggesting that the underlying driver of institutional E&S investment strategy in the pandemic is downside-risk protection. JEL Classification: G01, G12, G23, M14
Localized and widespread pressure pain hypersensitivity in patients with episodic or chronic migraine: A systematic review and meta-analysis
Authors: Fernández-de-las-Peñas César , Navarro-Santana Marcos J , Curiel-Montero Francisca , Plaza-Manzano Gustavo , Alburquerque-Sendín Francisco , Rodrigues-de-Souza Daiana P 
Published: March 2022

Objective This meta-analysis compared pressure pain sensitivity in trigeminal, cervical spine and remote pain-free areas between migraine patients and headache-free controls considering diagnosis (episodic versus chronic) and sex. Databases and data treatment: Electronic databases were searched for cross-sectional or prospective case-control studies comparing pressure pain thresholds between migraine and headache-free controls. Data were extracted by two reviewers. The risk of bias and methodological quality was assessed by Newcastle-Ottawa Quality Assessment Scale. Meta-analyses of trigeminal, extra-trigeminal (cervical spine) and remote pain-free areas were compared. Frequency of migraine and sex were taken into account. Mean differences (MD) and random effects were calculated. Results Eighteen studies were included. Patients with migraine showed lower pressure pain thresholds than headache-free controls: trigeminal (MD −71.33 kPa, 95%CI −92.14 to −50.53), cervical spine (MD −68.50 kPa, 95%CI −84.67 to −52.33), and remote pain-free (MD −62.49 kPa, 95%CI −99.52 to −25.45) areas. Differences were consistently significant for episodic migraine in all locations, but only significant in the trigeminal area for chronic migraine (MD −67.36 kOPa, 95%CI −101.31 to −33.42). Overall, women had lower pressure pain thresholds than men. The methodological quality of most studies (66.7%) was good. The results showed a high heterogeneity. Conclusion This meta-analysis found low to high quality evidence showing lower pressure pain thresholds in trigeminal, extra-trigeminal, and remote pain-free areas in migraine sufferers when compared with headache-free controls. Hypersensitivity to pressure pain locally and widespread was consistently observed in episodic migraine, but locally in chronic migraine as compared to headache-free controls. Women with migraine were more sensitive than men. Registration number: https://doi.org/10.17605/OSF.IO/YJTAK
Burden of headache in a HIV-positive population of sub-Saharan Africa
Authors: Leone Massimo , Giani Luca , Phaka Monica , Uluduz Derya , Tayyar Şaşmaz , Kamponda Maureen , Tolno Victor Tamba , Guidotti Giovanni , Marazzi Maria Cristina , Steiner Timothy J 
Published: March 2022

Background About 26 million people are living with HIV in sub-Saharan Africa. The DREAM programme in sub-Saharan Africa provides free healthcare for HIV/AIDS and a range of chronic non-communicable diseases. HIV is a risk factor for neurological non-communicable diseases including stroke and epilepsy, which themselves are associated with headache, and HIV may be a direct risk factor for headache. We investigated the prevalence and burden of headache in a HIV+ population in sub-Saharan Africa. Methods At the DREAM Centre in Blantyre, Malawi, a low-income country with a population of 19 million and 9.2% HIV prevalence, a structured questionnaire was administered by a trained lay interviewer to consecutively attending HIV+ patients aged 6–65 years. All were monitored with regular viral load detection. Results Of 513 eligible patients invited, 498 were included (mean age 34.1 ± 12.8 years; 72% females; 15 declined). All were on antiretroviral treatment, with viral load undetectable in 83.9%. The 1-year prevalence of headache was 80.3% (females 83.6%, males 71.9%); 3.8% had ≥15 headache days/month, 1.4% had probable medication-overuse headache. Mean overall headache frequency was 4.4 ± 5.4 days/month. Those reporting headache lost means of 2.3% of paid workdays and 3.3% of household workdays because of headache. Only one third had sought advice for their headache. Conclusions Headache is very prevalent among HIV+ patients in Malawi, imposing additional burden and costs on individuals and the community. Management of headache disorders should be implemented in HIV centres, as it is for other chronic non-communicable diseases.
Probing mechanical properties of graphene oxide/epoxy composites based on nano indentation technique
Authors: Zhao Cun , Zhao Yufen , Pei Xiaoyuan , Liu Shengkai , Xia Yuanhua , Min Chunying , Shao Ruiqi , Wang Chunhong , Wang Wei , Xu Zhiwei 
Published: March 2022

The silanized graphene oxide (KH-GO) with different mass fractions was dispersed in epoxy resin by a solution blending method and resin transfer molding process. The nano indentation method was used to test the micromechanical properties of GO/epoxy composites with different mass fractions, and the effect of GO on the hardness of epoxy matrix composites was quantitatively determined, and the influence of adding KH-GO on the thermal mechanical and bending properties of epoxy resin was discussed by dynamic thermal mechanical and universal strength machine tests. The experimental results show that the thermal and mechanical properties of composites are improved with the increase of the amount of KH-GO. Especially, when the content of KH-GO was 0.3%, the bending strength (125.4 MPa), hardness (281.0 MPa), and glass transition temperature (99.6°C) of composites reached the highest. It was proved that the composites showed its excellent performance and the silane coupling agent was successfully grafted to the graphene oxide by covalent bond, which effectively improved the interface compatibility of the reinforcing body and the matrix and was related to good dispersibility in the epoxy resin. This method is simple and effective, providing a certain reference value for the enhancement of the mechanical properties of the next generation of nanocomposites.
Development and Psychometric Properties of a Culturally Adapted Video Version of Strange Stories as a Measure of Advanced Theory of Mind in Youths
Authors: Nah Yong-Hwee , Chen Mo 
Published: March 2022

This study described the development of a culturally adapted video version of Strange Stories test as a measure of advanced theory of mind for youths in an Asian country (i.e. Singapore), the Y-ToM, and to provide preliminary psychometric properties. Participants were 170 youths (82 male, 88 female) aged from 13 to 16 years old (M = 14.77, SD = 1.16) in Singapore. The youths completed the Y-ToM, an abbreviated IQ test and the Happé’s Strange Stories in a counterbalanced order while their parents completed the Child Behavior Checklist (CBCL). A two-factor structure consisting of social and physical subscales was suggested. Concurrent, convergent, divergent and diagnostic validity of the Y-ToM was examined. Internal consistency of the Y-ToM social subscale was acceptable though it was not satisfactory for the Y-ToM physical subscale. Inter-rater reliability was good while test-retest reliability was lower.