bluuebunny/crossref_metadata_2025_split huggingface dataset:
The HF-AF ENERGY Trial: Nicotinamide Riboside for the Treatment of Atrial Fibrillation in Heart Failure Patients
Authors: Pool Lisa , Knops Paul , Manintveld Olivier C. , Brugts Jasper J. , Theuns Dominic A. M. J. , Brundel Bianca J. J. M. , de Groot Natasja M. S. 
Published: October 2022

Abstract

Background
The presence of atrial fibrillation (AF) in heart failure (HF) patients with reduced ejection fraction is common and associated with an increased risk of stroke, hospitalization and mortality. Recent research findings indicate that a reduction in nicotinamide adenine dinucleotide (NAD+) levels results in mitochondrial dysfunction, DNA damage and consequently cardiomyocyte impairment in experimental and clinical HF and AF. The HF-AF ENERGY trial aims to investigate the cardioprotective effects of the NAD+ precursor nicotinamide riboside (NR) treatment in ischemic heart disease patients diagnosed with AF.

Study design
The HF-AF ENERGY trial is a prospective intervention study. The study consists of a (retrospective) 4 months observation period and a 4 months intervention period. The cardioprotective effect of NR on AF burden is investigated by remote monitoring software of implantable cardiac defibrillators (ICDs), which enables continuous atrial rhythm monitoring detection. Cardiac dimension and function are examined by echocardiography. Laboratory blood analysis is performed to determine mitochondrial function markers and energy metabolism. All the study parameters are assessed at two fixed time points (pre- and post-treatment). Pre- and post-treatment outcomes are compared to determine the effects of NR treatment on AF burden, mitochondrial function markers and energy metabolism.

Conclusion
The HF-AF ENERGY trial investigates the cardioprotective effects of NR on AF burden and whether NR normalizes blood-based mitochondrial function markers and energy metabolites of the NAD metabolome in ischemic heart disease patients diagnosed with AF. The study outcomes elucidate whether NAD+ metabolism can be used as a future therapy for HF patients with AF.
The Strengths and Difficulties Questionnaire Dysregulation Profile Teacher-Report: Psychometric Properties and Associations with Aspects of School Experience
Authors: Levantini Valentina , Camodeca Marina , Gelati Carmen 
Published: October 2022

AbstractEmotional, cognitive, and behavioral dysregulation is a risk factor for severe outcomes, calling for reliable measures to assess it, including the Strengths and Difficulties Questionnaire Dysregulation Profile (SDQ-DP) defined by 5 or 15 items. This study explored for the first time the factor structure, internal consistency, and test-retest reliability of the SDQ-DPs teacher-report in a sample of Italian children (N = 1000; age 7–12 years). The gender invariance of the SDQ-DPs, construct validity, and associations with school variables were also evaluated. A first-order model for the SDQ-DP 5-item and a bifactor model for the SDQ-DP 15-item best fitted the data. Full measurement invariance across gender was confirmed only for the 15-item scale. Internal and test-retest reliabilities were weaker for the 5-item scale. Both SDQ-DPs were similarly associated with a measure of emotion regulation skills and some school variables. This study provides indications for a more conscious use of the two scales.
Strong bidirectional gene flow between fish lineages separated for over 100,000 years
Authors: Lutz Maiko L. , Sunnucks Paul , Chapple David G. , Gilligan Dean , Lintermans Mark , Pavlova Alexandra 
Published: October 2022

AbstractRestoring levels of genetic diversity in small and declining populations is increasingly being considered in biodiversity conservation. Evidence-based genetic management requires assessment of risks and benefits of crossing populations. Because risks are challenging to assess experimentally, e.g. through multi-generational crosses, decision-support approaches utilize proxy risk factors such as time since separation of lineages. However, the paucity of empirical datasets on fitness consequences of longer separation times tends to favour crossing lineages with conservatively short separations, restricting wildlife managers’ options. Here, we assessed the genetic outcomes of interbreeding in the wild between lineages of a threatened Australian freshwater fish (Macquarie perch) separated by an estimated 119,000–385,000 years of evolution in distinct environments. Fish belonging to the Murray-Darling Basin (MDB) lineage escaped from Cataract Dam—into which they were translocated in ~ 1915—into the Cataract River, where they interbred with the local Hawkesbury-Nepean Basin (HNB) lineage. Analyses of reduced-representation genomic data revealed no evidence of genetic incompatibilities during interbreeding of the two lineages in the Cataract River: assignment to genotypic clusters indicated a spectrum of hybrid types including second generation hybrids and backcrosses to both parental lineages. Thus, no adverse effects were detected from genetic mixing of populations separated by > 100,000 years. We are not advocating purposely crossing the two lineages for management purposes under present cost–benefit considerations, because there are currently sufficient intra-lineage source populations to beneficially mix. Instead, this study presents a useful calibration point: two morphologically different lineages evolved in different habitats for 119,000–385,000 years can successfully interbreed.
Digital and analogue Phenomenology
Authors: Lanfredini Roberta 
Published: October 2022

AbstractPhenomenology presents itself not as an explanation or interpretation of phenomena but as a description of them. Describing experience means making its internal structure explicit, which, in phenomenology, is an eidetic structure.The method of phenomenological explication or clarification is, however, by no means univocal. This paper aims to isolate the two fundamental ways in which phenomenological description is achieved. The first refers to a phenomenology of manifestation, based on the concept of determination or datum, which is realized in the phenomenological-static approach and, in particular, on the concept of extensive quality. The second refers to a phenomenology of disposition, based on the concept of tension or force – which is realized in the genetic approach as well as in Merleau-Ponty’s phenomenology of perception – and, in particular on the concept of intensive or forceful quality.The analysis of the difference between the two approaches allows us to introduce the crucial distinction between digital and analogue dimensions within phenomenology.
Linking Viscosity to Equations of State Using Residual Entropy Scaling Theory
Authors: Yang Xiaoxian , Xiao Xiong , Thol Monika , Richter Markus , Bell Ian H. 
Published: October 2022

AbstractIn our previous work (J Chem Eng Data 2021, 66(3):1385–1398), a residual entropy scaling (RES) approach was developed to link viscosity to residual entropy [a thermodynamic property calculated with an equation of state (EoS)] using a simple polynomial equation for refrigerants. Here, we present an extension of this approach to a much wider range of fluids: all pure fluids and their mixtures whose reference EoS and experimental viscosity data are available. A total of 84 877 experimental points for 124 pure fluids and 351 mixtures are collected from 1846 references. The investigated pure fluids contain a wide variety of fluids from light gases with quantum effects at low temperatures to dense fluids and fluids with strong intermolecular association. More than 68.2 % (corresponding to the standard deviation) of the evaluated experimental data agree with the RES model within 3.2 % and 8.0 % for pure fluids and mixtures, respectively. Compared to the recommended models implemented in the REFPROP 10.0 software (the state-of-the-art for thermophysical property calculation), if the dilute gas viscosity is calculated in the same way, our RES approach yields similar statistical agreement with the experimental data while having a much simpler formulation and fewer parameters. To use our RES model, a software package written in Python is provided in the supporting information.
Graphical Abstract
Canaloplasty and trabeculotomy with the OMNI® surgical system in OAG with prior trabecular microbypass stenting
Authors: Terveen Daniel C. , Sarkisian Steven R. , Vold Steven D. , Selvadurai Deepan , Williamson Blake K. , Ristvedt Deborah G. , Bleeker Adam R. , Dhamdhere Kavita , Dickerson Jaime E. 
Published: October 2022

Abstract
Purpose
Evaluate effectiveness and safety outcomes for patients treated with canaloplasty and trabeculotomy previously treated with a trabecular microbypass stent (TBS).

Methods
Retrospective, multicenter, IRB approved study. Patients treated with TBS (iStent/iStent inject, Glaukos) and subsequently with OMNI surgical system (OSS) (Sight Sciences). From 5 practices in 5 US states. Open-angle glaucoma (OAG), minimum 3 months follow-up after OSS surgery, Pre-OSS IOP ≥ 17 mmHg on ≥ 1 medication. No glaucoma procedures between TBS and OSS. Endpoints: proportion with ≥ 20% reduction in IOP, IOP between 6 and 18 mmHg, mean IOP, change in IOP, mean number of medications. Adverse events and secondary surgical interventions (SSI). Mann–Whitney rank sum test compared pre-OSS IOP and medications with follow-up.

Results
Twenty seven patients. Average age (SD) 72.2 (10.8), 22/27 primary OAG (82%), mean MD − 6.2 (7.0) dB. Mean IOP before OSS 22.3 (4.3) mmHg on 2.2 (1.3) medications. At last follow-up (mean 11 months) IOP was 17.2 mmHg on 1.8 medications, − 5.1 mmHg (− 23%, p < .001), − 0.4 meds (− 18%, p = .193); ≥ 20% IOP reduction (41%), IOP ≤ 18 (56%). Adverse events were non-serious. Hyphema > 1 mm (3, 11%), BCVA decrease (4, 15%), IOP spike (2, 7%). SSI (4, 15%) had higher pre-OSS IOP (23.4 mmHg) and worse MD (− 9.6 dB).

Conclusion
Patients uncontrolled by medication and a prior TBS would once have been candidates for trabeculectomy and tube shunts. OSS offered a minimally invasive option that provided IOP control and avoidance of traditional surgery for the majority over follow-up averaging 11 months and up to 42 months.
Transportation Sustainability and Relevant Ranking of European Countries
Authors: Grigoroudis Evangelos , Kouikoglou Vassilis S. , Phillis Yannis A. 
Published: October 2022

AbstractThe role of transportation in the economic process is central. Transportation’s benefits, however, can be dampened because of its environmental and social cost. A central question then arises as to the degre of sustainability of a national transportation system. In the present paper we develop a mathematical model to define and assess national transportation sustainability. The model relies on a number of indicators encompassing environmental impact, efficiency, safety, and economic contributions. Statistical data manipulations and fuzzy multistage reasoning result in an overall sustainability index over [0, 1]. A sensitivity analysis uncovers those indicators with the highest potential for improving transportation sustainability. Thirty European countries are ranked and the most important indicators for each country are pinpointed. It is demonstrated that greatest improvement will be achieved with the reduction of passenger car use, road freight transportation, and fatal accidents. Counterintuitively, Norway, Austria, Denmark, and Luxembourg rank at the bottom of the list together with Bulgaria, Greece, and Malta. This is due to their poor environmental performance and their small sustainability progress over 2010–2020.
Isolation and characterization of a main porin from the outer membrane of Salinibacter ruber
Authors: Farci Domenica , Cocco Emma , Tanas Marta , Kirkpatrick Joanna , Maxia Andrea , Tamburini Elena , Schröder Wolfgang P. , Piano Dario 
Published: October 2022

AbstractSalinibacter ruber is an extremophilic bacterium able to grow in high-salts environments, such as saltern crystallizer ponds. This halophilic bacterium is red-pigmented due to the production of several carotenoids and their derivatives. Two of these pigment molecules, salinixanthin and retinal, are reported to be essential cofactors of the xanthorhodopsin, a light-driven proton pump unique to this bacterium. Here, we isolate and characterize an outer membrane porin-like protein that retains salinixanthin. The characterization by mass spectrometry identified an unknown protein whose structure, predicted by AlphaFold, consists of a 8 strands beta-barrel transmembrane organization typical of porins. The protein is found to be part of a functional network clearly involved in the outer membrane trafficking. Cryo-EM micrographs showed the shape and dimensions of a particle comparable with the ones of the predicted structure. Functional implications, with respect to the high representativity of this protein in the outer membrane fraction, are discussed considering its possible role in primary functions such as the nutrients uptake and the homeostatic balance. Finally, also a possible involvement in balancing the charge perturbation associated with the xanthorhodopsin and ATP synthase activities is considered.
Sea Lamprey Alarm Cue Comprises Water- and Chloroform- Soluble Components
Authors: Mensch Emily L. , Dissanayake Amila A. , Nair Muraleedharan G. , Wagner C. Michael 
Published: October 2022

AbstractA diversity of aquatic organisms manage predation risk by avoiding waters activated with conspecific alarm cues, a chemical mixture released from injuries. The sea lamprey (Petromyzon marinus) is a nocturnal migratory species that relies on its alarm cue to navigate around areas of predation risk when moving through river channels. Identification of the cue’s chemistry would allow managers to harness this innate behavioral response to guide migrating sea lamprey to traps (invasive population in the Laurentian Great Lakes) or to fish passage devices where dams block migrations in their native range. We pursued isolation of the sea lamprey alarm cue through behaviorally guided fractionation, fractionating the alarm cue into water-soluble and chloroform-soluble fractions, each of which elicited a substantial avoidance response. Recombining the two fractions restored full reactivity, suggesting the alarm cue mixture contains components that exhibit high solubility in water (e.g., nitrogenous compounds), chloroform (e.g., lipids), or perhaps materials that dissolve readily in either solvent. We further screened 13 individual compounds or pure isolates and 6 sub-fractions from the water-soluble fraction and found one of the pure isolates, isoleucine, evoked an avoidance response on its own, but not consistently when found in other mixtures. In a third experiment, we observed no behavioral response after recombining 32 compounds isolated and identified from the water-soluble fraction. These results confirm other suggestions that the process of elucidating alarm cue constituents is challenging. However, we suggest the pursuit is worthwhile given the strong evidence for the utility of alarm cues for use in the conservation and management of fishes and other aquatic organisms.
The impact of habitat fragmentation on domatia-dwelling mites and a mite-plant-fungus tritrophic interaction
Authors: Graham Carolyn D. K. , Warneke Christopher R. , Weber Marjorie , Brudvig Lars A. 
Published: October 2022

Abstract
Context
Habitat fragmentation is a leading threat to biodiversity, yet the impacts of fragmentation on most taxa, let alone interactions among those taxa, remain largely unknown.

Objectives
We studied how three consequences of fragmentation—reduced patch connectivity, altered patch shape, and edge proximity—impact plant-dwelling mite communities and mite-plant-fungus interactions within a large-scale habitat fragmentation experiment.

Methods
We sampled mite communities from the leaves of Quercus nigra (a plant species that has foliar domatia which harbor fungivorous and predacious mites) near and far from edge within fragments of varying edge-to-area ratio (shape) and connectivity via corridors. We also performed a mite-exclusion experiment across these fragmentation treatments to test the effects of mite presence and fungal hyphal abundance on leaf surfaces.

Results
Habitat edges influenced the abundance and richness of leaf-dwelling mites; plants closer to the edge had higher mite abundance and species richness. Likewise, hyphal counts were higher on leaves near patch edges. Despite both mite and fungal abundance being higher at patch edges, leaf hyphal counts were not impacted by mite abundance on those leaves. Neither patch shape nor connectivity influenced mite abundance, mite species richness, or the influence of mites on leaf surface fungal abundance.

Conclusion
Our results suggest that mites and foliar fungi may be independently affected by edge-structured environmental gradients, like temperature, rather than trophic effects. We demonstrate that large-scale habitat fragmentation and particularly edge effects can have impacts on multiple levels of microscopic communities, even in the absence of cascading trophic effects.
Daily Stress Processes as Potential Intervention Targets to Reduce Gender Differences and Improve Mental Health Outcomes in Mid- and Later Life
Authors: Stawski Robert S. , Cichy Kelly E. , Witzel Dakota D. , Schuyler Ashley C. , Nichols Madeline J. 
Published: October 2022

Abstract
The current study examines daily stress processes as risk factors for comprised mental health in midlife and later life, specifically for gender differences in depression risk. Using data from the Midlife in the United States (MIDUS) study and the National Study of Daily Experiences (NSDE), we examine (1) gender differences in depression; (2) the prospective effects of differential exposure and affective responses on 10-year depression status; (3) gender differences in daily stress-depression links. Furthermore, we explore whether the protective factor of help-seeking behavior moderates the effects of daily stress on depression. Participants included 1289 (mage = 55; SD = 12; range = 34–83; 56% female) individuals who completed the second waves of MIDUS and the 8-day NSDE daily diary protocol and participated in the third wave of MIDUS approximately 10 years later. Respondents completed assessments of depression and their seeking assistance from a psychiatrist, mental health professional, counselor, or religious leader. Covariate-adjusted logistic regression analyses revealed increased odds of depression among women compared to men, but no significant gender difference after taking daily stress into account. Higher levels of stressor exposure, negative affect, and affective reactivity were associated with increased odds of depression for both men and women. Compared to those who did not engage in help-seeking behavior, those who did had significantly greater odds of depression, and there were asymmetric patterns of daily stress effects across groups. These findings highlight differential exposure, negative affect, and affective responses to daily stress as potentially accessible intervention targets for reducing stress in daily life and mitigating longer-term depression risk during mid- and later life.
Iodine status and supplementation in pregnancy: an overview of the evidence provided by meta-analyses
Authors: Croce Laura , Chiovato Luca , Tonacchera Massimo , Petrosino Elena , Tanda Maria Laura , Moleti Mariacarla , Magri Flavia , Olivieri Antonella , Pearce Elizabeth N. , Rotondi Mario 
Published: October 2022

AbstractIodine supplementation during pregnancy in areas with mild-moderate deficiency is still a matter of debate. The present study aimed at systematically reviewing currently available evidences provided by meta-analyses with the aim to further clarify controversial aspects regarding the need of iodine supplementation in pregnancy as well as to provide guidance on clinical decision-making, even in areas with mild-moderate deficiency. Medline, Embase and Cochrane search from 1969 to 2022 were performed. For the purpose of this review, only studies containing meta-analytic data were selected. A total of 7 meta-analyses were retrieved. Four meta-analyses evaluated the relationship between iodine status during pregnancy and neonatal and maternal outcomes suggesting the existence of a U-shaped correlation between iodine status and several maternal and neonatal consequences, especially if iodine status is evaluated at the beginning of pregnancy. Three meta-analyses evaluating the results of intervention trials failed to provide straightforward conclusions on the benefits of iodine supplementation in pregnant women in areas with mild-moderate iodine deficiency. Although evidence coming from meta-analyses suggests a role of iodine status during pregnancy in determining maternal and child outcomes, results of meta-analyses of intervention trials are still controversial. Several factors including, degree of iodine deficiency, and pooling studies conducted in areas with different iodine intake, may account for the lack of benefits reported by meta-analyses of intervention trials. More high-quality, randomized, controlled trials including information on timing, dose and regimen of iodine supplementation are needed to further elucidate this issue.
Students’ Representations of Menopause and Perimenopause: Out of Control Bodies and Empathetic Expert Doctors
Authors: Hayfield Nikki , Campbell Christine 
Published: October 2022

AbstractRepresentations of peri/menopause are influential in relation to how peri/menopause is understood and how peri/menopausal women are perceived, both of which have important implications for health and wellbeing. In this paper, we report results from a story completion study with 102 undergraduate psychology students. Participants were invited to write a response to a fictional scenario about a peri/menopausal woman. Thematic analysis was used to construct two themes. In the first theme,Women’s bodies out of control, we report how students represented peri/menopausal women’s bodies as unpredictable and uncontrollable. In the second theme,Doctors as empathetic experts: A (biomedical) problem in need of (medical) intervention, we demonstrate how participants wrote stories that portrayed peri/menopause as a medical problem to be easily and effectively resolved by a doctor. These doctors were consistently characterized as empathetic and as experts of peri/menopause. We consider the extent to which these fictional stories might (or might not) map onto women’s lived experiences of peri/menopause by drawing on extant literature. Our results contribute to understandings of how young people represent peri/menopause and peri/menopausal women. These results have implications for educators in ensuring that menopause is included in their curricula, and for health professionals in their practice.
Simplified Kinetic Model for $$\hbox {NH}_3$$-SCR Over Cu-CHA Based on First-Principles Calculations
Authors: Feng Yingxin , Creaser Derek , Grönbeck Henrik 
Published: October 2022

AbstractSelective catalytic reduction with ammonia as reducing agent ($$\hbox {NH}_3$$

NH
3

-SCR) is an efficient technology to control $$\hbox {NO}_\mathrm{x}$$

NO
x

emission during oxygen excess. Catalysts based on Cu-chabazite (Cu-CHA) have shown good performance for $$\hbox {NH}_3$$

NH
3

-SCR with high activity and selectivity at low temperature and good hydrothermal stability. Here, we explore a first-principles based kinetic model to analyze in detail which reaction steps that control the selectivity for $$\hbox {N}_2$$

N
2

and the light-off temperature. Moreover, a simplified kinetic model is developed by fitting lumped kinetic parameters to the full model. The simplified model describes the reaction with high accuracy using only five reaction steps. The present work provides insight into the governing reaction mechanism and stimulates design of knowledge-based Cu-CHA catalysts for $$\hbox {NH}_3$$

NH
3

-SCR.