bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health economic evidence for adjuvant chemotherapy in stage II and III colorectal cancer: a systematic review
Authors: To Yat Hang , Gibbs Peter , Tie Jeanne , IJzerman Maarten , Degeling Koen 
Published: July 2022

Abstract
Objective: The aims of this study was to appraise the health economic evidence for adjuvant chemotherapy (AC) strategies in stage II and III colorectal cancer (CRC) and to identify gaps in the available evidence that might inform further research.Method : A systematic review of published economic evaluations was undertaken. Four databases were searched and full-text publications in English were screened for inclusion. A narrative synthesis was performed to summarise the evidence.Results: Thirty-eight studies were identified and stratified by cancer stage and AC strategy. The majority (89%) were full economic evaluations considering both health outcomes, usually measured as quality-adjusted life years (QALYs), and costs. AC was found to be cost-effective compared to no AC for both stage II and III CRC. Oral and oxaliplatin-based AC was cost-effective for stage III. Three months of CAPOX was cost-effective compared to 6-month in high-risk stage II and stage III CRC. Preliminary evidence suggests that biomarker approaches to AC selection in stage II can reduce costs and improve health outcomes. Notably, assessment of QALYs were predominantly reliant on a small number of non-contemporary health-utility studies. Only 32% of studies considered societal costs such as travel and time off work. Conclusions: Published economic evaluations consistently supported the use of AC in stage II and III colorectal cancer. Biomarker-driven approaches to patient selection have great potential to be cost-effective, but more robust clinical and economic evidence is warranted. Patient surveys embedded into clinical trials may address critical knowledge gaps regarding accurate assessment of QALYs and societal costs in the modern era.
The evolutionarily conserved gene Arrdc5 is required for male fertility
Authors: Oatley Jon , Giassetti Mariana , Miao Deqiang , Law Nathan , Oatley Melisaa , Park Julie , Maddison Lisette , Bernhardt Miranda 
Published: July 2022

Abstract
In sexually reproducing organisms, sperm contribute half the genomic material required for creation of offspring and natural fertility relies on males producing millions by way of spermatogenesis. This process is essential for continuity and diversity of a species, yet evolutionarily conserved core molecular regulators are undefined. Here we used single cell RNA-sequencing of testicular tissue from mice, pigs, and cattle to generate a multispecies integrated transcriptome database. Through bioinformatic analysis, the gene arrestin-domain containing 5 (Arrdc5) which encodes for an α-arrestin molecule was identified as a potential evolutionarily conserved regulator of spermatogenesis. Expression of Arrdc5 is testis specific in mice, pigs, cattle, and humans. Knockout of Arrdc5 in mice leads to male specific sterility due to production of low numbers of sperm that are immotile and malformed, resembling oligoasthenoteratospermia (OAT) which is a common diagnosis of infertility in men. Spermiogenesis, the final phase of spermatogenesis when round spermatids morphologically transform to spermatozoa, is defective in testes of Arrdc5 deficient mice. Also, epididymal sperm in Arrdc5 knockouts are unable to capacitate and fertilize oocytes. These findings establish ARRDC5 as a core regulator of mammalian spermatogenesis. Considering the role of arrestin molecules as modulators of G-protein coupled signaling and ubiquitination, ARRDC5 is a potential male contraceptive target.
Antimicrobial and antioxidative properties of Cleome viscose leaf extract
Authors: Sharma Hirdesh , Shrivastava Archana 
Published: July 2022

Abstract
The annual, sticky plant Cleome viscose Linn. (Capparidaceae), sometimes known as "Jakhya," thrives as a weed across India's plains and throughout the tropics. The entire plant and its components are extensively used in traditional and folklore medicine (seeds, leaves, roots and barks). We evaluated the antimicrobial and antioxidant capacity of Cleome viscose leaf extract.Methods: Methanol was used to extract the leaves. Extract was analysed qualitatively and quantitatively. Antioxidative properties of extract was assayed using DPPH, FRAP, ABTS H2O2 scavenging assay. Correlation between antioxidant activity, phenolic content and flavonoid content was estimated. Antimicrobial activity of Cleome viscose Linn leaf methanolic extract was estimated against Staphylococcus aureus, Vibrio cholera, Salmonella Typhimurium.Result: The methanolic extract of Cleome viscose leaves showed good antioxidant and antimicrobial potential. The extract was having alkaloids, phenolics, flavonoids and tannins as major phytochemicals. The extract showed good ABTS scavenging activity and moderate DPPH scavenging activity. The TPC strongly while TFC moderately correlated with antioxidant activity of the extract.Conclusion: Methanolic extract of Cleome viscose leaves demonstrated significant antioxidant and antibacterial activity. The phytoconstituents found in plant leaves, primarily phenolics, flavonoids, alkaloids, and tannins, are thought to be responsible for the plant's antioxidant and antimicrobial properties, making it a therapeutically important plant with the potential to be used as a drug as an antioxidant or against microbial diseases.
Mapping the Restoration of Degraded Peatland as a Field of Research Area: A Scientometric Review
Authors: Apori Samuel Obeng 
Published: July 2022

Abstract
Degraded peatland reduced many ecosystem services such as water quality and quantity, biodiversity, carbon storage, climate regulations and other cultural benefits. Therefore, several initiatives for the restoration of degraded peatland (RDP) have been attempted to restore the ecosystem processes, productivity and services of the degraded peatland to its original natural condition. Notwithstanding the popularity of RDP research among researchers and industry practitioners, a quantitative technique to map a comprehensive survey of the intellectual core and the general body landscape of knowledge on RDP research does not exist. In this study, a scientometric analysis was employed to analyze 522 documents using VOSviewer and CiteSpace. The Web of Science database was used to retrieve bibliographic records using the advanced search “TS (topic) =(‘drained peatland restoration’ OR ‘drained bog restoration’ OR ‘drained mire restoration’ OR degraded peatland restoration’ OR ‘degraded bog restoration’ OR ‘drained peatland reclamation’ OR ‘drained bog restoration’ OR ‘degraded peatland reclamation’ OR ‘degraded bog reclamation’ OR ‘drained mire restoration’ OR ‘degraded mire reclamation’ OR ‘degraded fen restoration’ OR ‘drained fen reclamation’). The outcome sought to provide relevant information in RDP research such as (i) publication trends (ii) research outlets (iii) most influential keywords (iv) most influential institutions and authors (v) top influential countries active in RDP research. In addition, four clusters were identified for ascertaining the central theme of RDP research in which cluster one is linked to the central research theme-“impact of drainage on peatland ecosystem services; cluster two focused on the impact of peatland restoration on greenhouse gas emissions; cluster three is associated with peatland restoration and biogeochemical properties and cluster four is related to peatland restoration and species richness. A new research hotspot such as soil respiration was identified via the keywords with the strongest citation bursts. This study will provide the various stakeholders such as industry, journal editors, policymakers and researchers instinctive understanding of the research status and the development frontier of RDP research
Atoms in Gaseous and Solid States and their Energy and Force Relationships under Transitional Behaviors
Authors: Ali Mubarak 
Published: July 2022

Abstract
By recalling the conventional studies of atoms, it is possible to discover new insights tackling the present and future challenges. Atoms of different elements form by electrons and energy knots. Atoms in elements recognize based on their electrons. The intercrossing of the photons having fixed lengths and numbers construct the lattice of an atom. The lengths and numbers of the intercrossed photons depend on the filled and unfilled states an atom possesses for its element. The intercrossing overt photons in a gaseous atom lattice are different than in the solid atom lattice. Except for the hydrogen atom, the atoms possess the same valency as specified. In the hydrogen atom, two energy knots occupy two electrons. In the helium atom, four energy knots occupy four electrons. A helium atom forms a zeroth ring in atoms of all higher-order elements. The study of protons and neutrons is no longer significant. Electrons of a gaseous atom deal with the minimum required potential energy, whereas the maximum is in a solid atom. Electrons in a gaseous atom experience the maximum required levitational force along the north pole. However, electrons experience the maximum required gravitational force along the south pole in a solid atom. In the transition state, electrons undertake infinitesimal displacements by remaining within the occupied energy knots, but they study a different nature of orientation for a gaseous atom and solid atom. These sorts of investigations study the atoms differently than the previous ones.
The Association Between the Risk of Breast Cancer and Epigallocatechin-
3-Gallate Intake: A Literature Review of a Potential Chemopreventive
Agent
Authors: Athanasiou Efstratios , Verras Georgios-Ioannis , Papageorgiou Savvas , Kelesis Ioannis , Gatsis Athanasios , Karaoulani Christina , Stouras Ioannis , Kanatas Panagiotis , Saitani Elmina-Marina , Oikonomou Maria-Eleni , Vlassi Danae-Anastasia , Vasileiou Maria , Tsagkaris Christos , Alexiou Athanasios , Kamal Mohammad Amjad 
Published: July 2022

Abstract:
According to the latest epidemiological data, breast cancer has recently been
the most frequently diagnosed malignancy. To date, a body of evidence has established
the involvement of multiple - and frequently interrelated - genetic and environmental factors
in the pathogenesis of the disease. Emerging research on cancer prevention has highlighted
the deterrence potential of interventions targeting environmental risk factors, particularly
diet. In this aspect, the current review reveals the latest scientific results regarding
epigallocatechin-3-gallate (EGCG) - a catechin most commonly found in green tea,
as a potential chemopreventive dietary agent against breast cancer. in vitro studies on
EGCG have demonstrated its effect on cell cycle progression and its potential to suppress
several intracellular signaling pathways involved in breast cancer pathogenesis. In addition,
EGCG possesses specific apoptosis-inducing characteristics that seem to enhance
its role as a regulator of cell survival. Preclinical data seem to support using EGCG as an
effective adjunct to EGFR-targeting treatments. The authors’ appraisal of the literature
suggests that although preclinical evidence has documented the anticarcinogenic features
of EGCG, limited large-scale epidemiological studies are investigating the consumption
of EGCG - containing nutrients in the prevention and management of breast cancer risk.
This literature review aims to liaise between preclinical and epidemiological research,
surveying the existing evidence and unraveling relevant knowledge gaps.
Nano-vaccination Strategies: Applications and Challenges for Intranasal Immunization
Authors: Pandya Tosha , Joshi Prachi , Pathak Rudree , Shah Shreeraj 
Published: July 2022

Abstract:The nasal route, a subgroup of mucosal delivery systems, constitutes a lucrative and encouraging substitute for administering drugs and vaccines. Over the years, a lot of research has been done in this area, and scientists have successfully explored this pathway using novel formulations to combat several infections. This review article aims to address the pathways of mucosal immunization, the dominance of the nasal route over other mucosal routes for immunization, and the mechanism of generation of immunogenic response via nasal route and nanotechnology-based approaches for intranasal vaccination. The immunotherapeutic and vaccinations for intranasal administration available in the market are also discussed, along with a brief overview of the products in the pipeline. It can also be assumed that such an approach can prove to be favorable in designing vaccinations for the current uncertain times. In spite of some dubious views on this.
Overview of Piperine: Bioactivities, Total Synthesis, Structural Modification,
and Structure-Activity Relationships
Authors: Li Shaochen , Lv Min , Xu Hui 
Published: July 2022

Abstract:
Natural products are an invaluable source for the discovery of drug and pesticide candidates.
Piperine, a simple and pungent alkaloid, is isolated from several plants of Piperaceae.
Piperine and its derivatives displayed a wide range of biological properties, such as antitumor activity,
anti-inflammatory activity, antioxidant activity, neuroprotective activity, insecticidal activity,
etc. In recent years, lots of works focused on the biological activities, mechanisms of action,
total synthesis, and structural modifications of piperine and its derivatives have been conducted.
To the best of our knowledge, however, few review articles related to the biological activities,
mechanisms of action, total synthesis, and structural modifications of piperine and its derivatives
have been reported to date. Therefore, this review summarizes the research advances (from 2014
to 2020) of piperine and its derivatives regarding bioactivity, mechanisms of action, total synthesis,
and structural modifications. Meanwhile, the structure-activity relationships of piperine and
its derivatives are also discussed.
Does Weekends Effect Exist in Asia? Analysis of Endovascular Thrombectomy
for Acute Ischemic Stroke in A Medical Center
Authors: Wang Charles C.N. , Lin Chia-Wei , Huang Hung-Yu , Guo Jeng-Hung , Chen Wei-Laing , Shih Hong-Mo , Chu Hsueh-Ting , Hsu Tai-Yi 
Published: July 2022

Background:
Discussing the quality measurements based on interrupted time series in
ischemic stroke, delays are often attributed to weekends effect. This study compared the metrics and
outcomes of emergent endovascular thrombectomy (EST) during working hours versus non-working
hours in the emergency department of an Asian medical center.

Methods:
A total of 297 patients who underwent EST between January 2015 and December 2018
were retrospectively included, with 52.5% of patients presenting during working hours and 47.5%
presenting during nights, weekends, or holidays.

Results:
Patients with diabetes were more in non-working hours than in working hours (53.9% vs.
41.0%; p=0.026). It took longer during nonworking hours than working hours in door-to -image
times (13 min vs. 12 min; p=0.04) and door-to-groin puncture times (median: 112 min vs. 104 min;
p=0.042). Significant statistical differences were not observed between the two groups in neurological
outcomes, including successful reperfusion and complications such as intracranial hemorrhage
and mortality. However, the change in National Institute of Health Stroke Scale (NIHSS) scores in
24 hours was better in the working-hour group than in the nonworking-hour group (4 vs. 2;
p=0.058).

Conclusions:
This study revealed that nonworking-hour effects truly exist in patients who received
EST. Although delays in door-to-groin puncture times were noticed during nonworking hours, significant
differences in neurological functions and mortality were not observed between working and
non-working hours. Nevertheless, methods to improve the process during non-working hours should
be explored in the future.
Characteristics of Amphetamine Psychosis with Respect to the Length of
Drug Exposure
Authors: Sokolova Iryna , Babina Anastasia , Vysotskyi Mykhailo 
Published: July 2022

Background:
Over the past decade, the number of individuals requiring medical care for
amphetamine-related psychosis has increased.

Objective:
This study aims to examine the psychological characteristics of amphetamine psychosis in
drug-addicted patients depending on the length of drug exposure and compared to patients diagnosed
with paranoid schizophrenia.

Method:
The study was carried out in psychiatric clinic No. 1 in Kyiv (Ukraine) in 2019, involving
107 patients. Of all the participants, 50 were included in Group 1 (methamphetamine psychosis) and
57 - in Group 2 (paranoid schizophrenia). All patients were treated with medication to relieve exacerbating
symptoms. They underwent extensive testing to determine the impairment severity of cognitive
function, attention, and task performance during remission.

Results:
In Group 1, the timing of onset for paranoid symptoms depends on the length of amphetamine
exposure (Spearman correlation coefficient = 0.89). The efficacy and dynamics of drug treatment
in Group 2 were similar to patients in Group 1. However, the effect of reduction in Group 2 was
achieved only in 4 months. Delusions, emotional disturbances, hallucinations in patients of Group 1
occurred 2.3 times more frequently than in Group 2 (p ≤ 0.05). The patients of Group 1 are characterized
by the presence of disorders related to the affective and behavioral components.

Conclusion:
All reported exacerbations are related to amphetamine use. Patients in Group 1 learned a
smaller number of words compared to those in Group 2. Besides, a large number of errors and difficulties
with shifting focus were recorded.
Probing the Ubiquitination-Mediated Function of Epithelial Sodium
Channel in A549 Cells
Authors: Oz Murat , Shabbir Waheed , Susan Yang Keun-Hang , Dogar Afzal M. , Isaev Dmytro 
Published: July 2022

Background:
The activity of the amiloride-sensitive epithelial sodium channel
(ENaC) in the tight epithelia of the lung is regulated by proteolytic activation and ubiquitination.
Pathophysiology of lung diseases is directly related to changes in one or both of these mechanisms.

Methods:
In this study, we investigated the impact of ubiquitination and cathepsin-mediated proteolytic
activation mechanisms on the functional regulation of ENaC in lung cancer A549 cells
using the patch-clamp technique.

Results:
Our findings suggest that inhibiting the proteasome (polyubiquitination) with MG132
improves ENaC activity, whereas altering the pH of the lysosome (monoubiquitination inhibition)
with NH4Cl has no effect on ENaC activity. In A549 cells, inhibition of cathepsin B
(CSTB) decreased the ENaC current, open probabilities (NPo and Po), and the number of active
channels.

Conclusion:
These findings delineate novel modes of ENaC degradation and proteolytic activation
of functional channels in A549 cells. Our findings indicate that both proteolytic activation
and ubiquitination of ENaC significantly affect channel function and add new insights into the
endogenous ENaC processing which might help to further understand the pathophysiology of the
lung disease.
Intelligent Load Balancing Algorithms for Internet of Things - A Review
Authors: Gul Safia , Malik Bilal Ahmad , Banday Mohamad Tariq 
Published: July 2022

Abstract:
The Internet of Things has witnessed an upsurge in the number of sensors communicating
with each other over the Internet, and this number, currently in billions, is increasing at an expeditious
pace. However, this augmentation in the number of interlaced devices can lead to profusion and jamming of the network, thereby degrading energy, latency, and throughput. Load balancing of the network is one of the techniques which could alleviate this issue. This paper reviews the methods that
have been employed for load balancing of the Internet of Things, thereby serving the research community two-fold. Firstly, it gives a comprehensive introduction to the classification of load balancing
algorithms. Secondly, it offers researchers the prospect of developing intelligent novel algorithms
catering to the load balancing predicament.
3D-Printed Microfluidics Potential in Combating Future and Current
Pandemics (COVID-19)
Authors: Eassa Heba A. , Helal Nada A. , Amer Ahmed M. , Fouad Aliaa , Bedair Asser F. , Nagib Reem , Mansoor Ihab , Hawash Motaz , Abdul-Latif Maha , Mohammed Kamilia H.A. , Helal Mohamed A. , Nounou Mohamed Ismail 
Published: July 2022

Abstract:
Coronavirus disease (COVID-19) emerged in China in December 2019. In March 2020, the
WHO declared it a pandemic leading to worldwide lockdowns and travel restrictions. By May, it infected
4,789,205 and killed 318,789 people. This led to severe shortages in the medical sector besides
devastating socio-economic effects. Many technologies such as artificial intelligence (AI), virtual reality
(VR), microfluidics, 3D printing, and 3D scanning can step into contain the virus and hinder its extensive
spread. This article aims to explore the potentials of 3D printing and microfluidic in accelerating
the diagnosis and monitoring of the disease and fulfilling the shortages of personal protective
equipment (PPE) and medical equipment. It highlights the main applications of 3D printers and microfluidics
in providing PPE (masks, respirators, face shields, goggles, and isolation chambers/hoods),
supportive care (respiratory equipment) and diagnostic supplies (sampling swabs & lab-on-chip) to
ease the COVID-19 pressures. Also, the cost of such technology and regulation considerations are addressed.
We conclude that 3D printing provided reusable and low-cost solutions to mitigate the shortages.
However, safety, sterility, and compatibility with environmental protection standards need to be
guaranteed through standardization and assessment by regulatory bodies. Finally, lessons learned from
this pandemic can also help the world prepare for upcoming outbreaks.
Diabetes Self-management Apps: Systematic Review of Adoption Determinants and Future Research Agenda
Authors: Alaslawi Hessah , Berrou Ilhem , Al Hamid Abdullah , Alhuwail Dari , Aslanpour Zoe 
Published: July 2022

Background
Most diabetes management involves self-management. Effective self-management of the condition improves diabetes control, reduces the risk of complications, and improves patient outcomes. Mobile apps for diabetes self-management (DSM) can enhance patients’ self-management activities. However, they are only effective if clinicians recommend them, and patients use them.

Objective
This study aimed to explore the determinants of DSM apps’ use by patients and their recommendations by health care professionals (HCPs). It also outlines the future research agenda for using DSM apps in diabetes care.

Methods
We systematically reviewed the factors affecting the adoption of DSM apps by both patients and HCPs. Searches were performed using PubMed, Scopus, CINAHL, Cochrane Central, ACM, and Xplore digital libraries for articles published from 2008 to 2020. The search terms were diabetes, mobile apps, and self-management. Relevant data were extracted from the included studies and analyzed using a thematic synthesis approach.

Results
A total of 28 studies met the inclusion criteria. We identified a range of determinants related to patients’ and HCPs’ characteristics, experiences, and preferences. Young female patients were more likely to adopt DSM apps. Patients’ perceptions of the benefits of apps, ease of use, and recommendations by patients and other HCPs strongly affect their intention to use DSM apps. HCPs are less likely to recommend these apps if they do not perceive their benefits and may not recommend their use if they are unaware of their existence or credibility. Young and technology-savvy HCPs were more likely to recommend DSM apps.

Conclusions
Despite the potential of DSM apps to improve patients’ self-care activities and diabetes outcomes, HCPs and patients remain hesitant to use them. However, the COVID-19 pandemic may hasten the integration of technology into diabetes care. The use of DSM apps may become a part of the new normal.