bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metastatic risk of prognostic fine-needle aspiration biopsy in u veal melanoma patients
Authors: Levashov I. A. , Yarovoi A. A. , Yarovaya V. A. , Bulgakova E. S. 
Published: July 2022

Despite the widespread u se of fine-needle aspiration biopsy (FNAB) of uveal melanoma (UM) for prognostic purposes, there are still doubts about the safety of this procedure. No analysis of such data can be found in domestic literature, and foreign authors have published only a few papers on this issue.The purpose of this study is to analyze the risk of metastasis in patients with UM during FNAB.Two groups of patients were formed: the main group, where FNAB was performed during brachytherapy (BT) (BT + FNAB) (n = 70), and the control group, where only BT was performed (n = 144).According to the obtained data, the probability of metastases during a 3‑year follow-up period did not significantly differ between the two groups (p = 0.22 by Fisher's exact test and p = 0.11 by log-rank test when assessing survival using the Kaplan – Meier method), the relative risk (RR) was 1.43 [95 % CI 0.79 to 2.24]. In addition, there was no significant difference in the main clinical outcomes of local treatment associated with worse prognosis: the degree of tumor regression (p = 0.46), extrascleral growth, the need for additional brachytherapy (p = 0.32) or secondary enucleation (p = 0.99).The absence of a significant difference in patient survival between the BT and BT + FNAB groups opens up prospects for a more extensive use of FNAB in patients with UM for prognostic purposes.
Comparison of the effects of two different doses of Filgrastim in febrile neutropenia management in childhood malignancy: A randomized clinical trial
Authors: Mirbehbahani Nargesbeigom , Bagheri Sepide , Roshandel Gholamreza , Jahazi Azam , Rashidbaghan Azam 
Published: July 2022

Background: Febrile neutropenia (FN) is most often caused due to chemotherapy. Solid or certain lymphoproliferative malignancies can increase the duration of hospitalization and other complications in cancer patients. Filgrastim is used in childhood FN management. This study aimed to compare the effect of two different doses of Filgrastim on hematological and paraclinical factors in hospitalized febrile neutropenic patients with cancer.
Materials and methods: In this randomized clinical trial, 60 febrile neutropenic patients with cancer complying with the inclusion criteria were assigned to both groups A and B. Thirty patients in group A received Filgrastim 5μg/kg/day whereas 30 others in group B received Filgrastim 15μg/kg/day. Hematological factors, physical examination findings, antibiotic administration period, and type of malignancy were then recorded. Complete blood count with differential (CBC diff) was also tested. Lung infiltration was examined by chest X-ray (CXR), and the spleen and abdomen were monitored by ultrasound.
Results: The mean age of patients was 6 ± 3 years old. The most prevalent malignancies included acute lymphoblastic leukemia (ALL) (35.0%), neuroblastoma (18.3%), osteosarcoma (11.7%), acute myeloid leukemia (AML) (8.3%), and Rhabdomyosarcoma (8.3%). The frequency distribution of malignancies significantly differed between the two groups (P= .01). Changes in hematological factors, including white blood cells (WBC), mature neutrophil cells, and absolute neutrophil count (ANC) in group A, appeared lower than those in the other group. However, none of the studied factors, including hematological factors, physical examination findings, and antibiotic administration period, were found to differ significantly between the two groups (P> 0.05).
Conclusion: Much as a higher dose of Filgrastim seems to bear a better effect on ANC, no significant difference was identified between the two groups. Further studies should be designed with a larger population to address the issue.
Frequency Determination of c.1115_1118delTTGG and c.3788_3790delTCT FANCA Gene Mutation in North of Khyber Pakhtunkhwa (KPK) Pakistan Fanconi’s Anemia Population
Authors: Ayaz Kinza , Khan Adnan , Arabdin Maria , Masood Tariq , Taj Abid Sohail , Ayaz Maaz 
Published: July 2022

Background: This study aimed to assess the frequency determination of c.1115_1118delTTGG and c.3788_3790delTCT Fanconi's anemia A gene (FANCA) gene mutation in the North of Khyber Pakhtunkhwa (KPK) Pakistan Fanconi’s Anemia Population.
Materials and Methods: A cross-sectional study was conducted at Khyber Medical University, Peshawar, Pakistan. For the Exon 13 mutation c.1115_1118delTTGG, the amplification-refractory mutation system polymerase chain reaction (ARMS PCR) was developed. Sanger sequencing confirmed the ARMS PCR results for Exon 13 and found an exon 38 mutation of the FANCA (Fanconi anemia complementation group A) gene (c.3788_3790delTCT). Sanger sequencing results analyzed on Bio edit sequence aligner software confirmed the results of PCR. The four incidental single nucleotide polymorphisms (SNPs) discovered were examined in several variation databases.
Results: The mean age for the patients was 9.68±3.02 years, with an age range of 5–16 years. Pedigree analysis of Fanconi Anemia patients revealed an autosomal recessive pattern of inheritance. Physical characteristics such as skeletal abnormalities, specifically thumb abnormalities and Fanconi's facies, are distinctive diagnostic features of FA. Pedigrees also showed bone marrow hypoplasia in 65% of patients and red cell aplasia in 6%. PCR results from all samples revealed tahat none of them had the Exon 13 mutation. In addition, none of the samples had the Exon 38 mutation. Four SNPs were found in the Sanger sequencing. Two of them were in the intron 12 region, one in each of Exons 13 and 38.
Conclusion: Results show that mutations in Exon 13 and Exon 38 of the FANCA gene are uncommon in our Pakistani FA population. SNPs established in the Pakistani population of Khyber Pakhtunkhwa (KPK) province have not been reported before.
Calibration of Complex Discrete Fracture Network Using Microseismic Events and Fracture Propagation Modelling with Seamless Reservoir Production Simulation
Authors: Li Yanchao , Zhang Qing , Gong Yiwen , Liu Chuxi , Leines-Artieda Joseph Alexander , Yu Wei 
Published: July 2022

Abstract
During the unconventional reservoir development, a proper modelling of the underground fracture networks and their effects on production is crucial for reservoir development potential and realistic economic analysis. Conventionally, the complex fracture system formed by hydraulic and natural fractures is extremely difficult to capture, let alone to numerically simulate it. Most importantly, the current best solution can only rely on the knowledge of the natural fractures from the geology and geophysics team and hydraulic fractures from the engineering team. Nevertheless, this solution fails to realize the dynamic stress regime variations when fracturing jobs are done within the horizontal wellbore. In this study, a variety of data source and modelling tools is harnessed to delineate a more realistic and representative discrete fracture network (DFN). The first step is to obtain the original natural fractures already depicted from geological and geophysical information and the statistical information regarding the spatial configurations of this DFN. Next, a new set of natural fractures is generated by an in-house natural fracture generator while preserving the spatial characteristics of the original natural fractures at the same time. Then, a combined DFN of the original natural fracture and newly generated natural fractures is accomplished. This combined DFN is then intensity-calibrated by the given microseismic cloud events, especially focusing on the near-wellbore region. Then, a displacement discontinuity method- (DDM-) based in-house hydraulic fracture propagation model is used to generate hydraulic fractures with complex boundaries, honoring the fracturing job logistics from the engineering team. After this step, an ultimate and highly representative DFN can be achieved. By applying this very novel workflow, DFN characterizations of both a single-well scenario and well-pad (3 wells) scenarios have been highly successful. Statistics such as the cluster-wise hydraulic fracture half-length, height, aperture, and numbers of activated/nonactivated natural fractures can be easily presented. Through the powerful numerical method called the embedded discrete fracture model (EDFM), production simulation and stimulated reservoir volume evaluation can be seamlessly studied. Extents of 3D drainage volumes can also be plotted with ease. Overall, a holistic picture regarding the unconventional reservoir’s underground DFN can be reliably depicted, using the proposed workflow.
Dynamic Sealing Behavior of Sand Self-Juxtaposition Windows on a Trap-Bounding Fault in a Natural Gas Storage Site
Authors: Zhang Xiaoling , Fu Xiaofei , Wang Yachun , Meng Lingdong , Du Ruishan , Hong Shuxin , Yang Hongsong , Fu Xiandi , Cheng Yabin , Li Jian , Zhang Baishuang 
Published: July 2022

Abstract
An understanding of across-fault seals is essential for planning an injection/production strategy for a fault-bounded gas storage site. In addition, it is more likely to permit lateral leakage for a fault with sand self-juxtaposition windows. This paper is aimed at identifying the dynamic sealing behaviors of a sand self-juxtaposition fault on the geological and gas injection timescales. Banzhongbei gas storage site, China, was taken as a target area, and fault seals and hydrocarbon distributions within the original reservoirs were studied. The results showed that across-fault pressure differences of 0.085~0.146 MPa (equivalent to 41.6~71.5 m oil-column and 27.0~46.4 m gas-column heights) were supported by sand self-juxtaposition windows on the B816 fault, and the resultant absolute permeability (5.97×10−2~5.69×10−1 mD) of the fault was nearly 3~4 orders of magnitude lower than the average absolute permeability of reservoirs (1.16×102 mD). Gas composition contrasts, between the original and injection gas coupled with dynamic pressure monitoring data, indicated that lateral leakage occurred across sand self-juxtaposition windows under the condition of high across-fault pressure difference. However, the low-permeability fault showed strong negative influence on the efficiency of fluid flow in the model calculations and prolongs the timescales of pressure-difference decayed as much as 5 orders of magnitude relative to those of nonfault model calculations. These modeled dynamic sealing behaviors of sand self-juxtaposition windows may lead to a better understanding of the relative retardation of across-fault gas flow by weak sealing faults on the gas injection/production timescale.
The Aggression of the Russian Federation against Ukraine: International Law and Power Politics or ‘What Happens Now’
Authors: Kwiecień Roman 
Published: July 2022

The article deals with the relationship between international law and power politics in the light of the Russian aggression against Ukraine. The relationship between international law and politics is very close, even natural, since the principles and rules of international law primarily act in international relations, that is in a political reality. It is the problem of observance and violations of the legal principles and rules on the use of force that is the key point of reference for the discussion of this issue. The serious breach of Article 2(4) of the UN Charter by Russia, the crime of aggression and other alleged crimes committed during this international armed conflict incline the author to address some questions on the power and weakness of international law. The power of international law is severely tested when it comes to the unilateral use of force by states. The Russian aggression against Ukraine is arguably the most important such test since the end of World War II, at least in Europe. The author claims that such crises as the Russian aggression against Ukraine clearly prove that international law is what states want it to be.
Predicting Multiple Sclerosis Outcomes During the COVID-19 Stay-at-home Period: Observational Study Using Passively Sensed Behaviors and Digital Phenotyping
Authors: Chikersal Prerna , Venkatesh Shruthi , Masown Karman , Walker Elizabeth , Quraishi Danyal , Dey Anind , Goel Mayank , Xia Zongqi 
Published: July 2022

Background
The COVID-19 pandemic has broad negative impact on the physical and mental health of people with chronic neurological disorders such as multiple sclerosis (MS).

Objective
We presented a machine learning approach leveraging passive sensor data from smartphones and fitness trackers of people with MS to predict their health outcomes in a natural experiment during a state-mandated stay-at-home period due to a global pandemic.

Methods
First, we extracted features that capture behavior changes due to the stay-at-home order. Then, we adapted and applied an existing algorithm to these behavior-change features to predict the presence of depression, high global MS symptom burden, severe fatigue, and poor sleep quality during the stay-at-home period.

Results
Using data collected between November 2019 and May 2020, the algorithm detected depression with an accuracy of 82.5% (65% improvement over baseline; F1-score: 0.84), high global MS symptom burden with an accuracy of 90% (39% improvement over baseline; F1-score: 0.93), severe fatigue with an accuracy of 75.5% (22% improvement over baseline; F1-score: 0.80), and poor sleep quality with an accuracy of 84% (28% improvement over baseline; F1-score: 0.84).

Conclusions
Our approach could help clinicians better triage patients with MS and potentially other chronic neurological disorders for interventions and aid patient self-monitoring in their own environment, particularly during extraordinarily stressful circumstances such as pandemics, which would cause drastic behavior changes.
FORMULATION AND CHARACTERIZATION OF ASTAXANTHIN LOADED SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS)
Authors: Tungadi Robert , Jusuf Herlina 
Published: July 2022

Aim and Objective: SNEDDS (Self Nano Emulsifying Drug Delivery System) is an isotropic mixture of oil, surfactant, and co-surfactant which forms nanoemulsions spontaneously when comes in contact with gastric fluid thereby increasing the solubility of active substances. Astaxanthin is one of the active substances having low solubility so it suits well with this nanoformulation. This study aims to formulate and characterize Astaxanthin SNEDDS.
Methods: This research is a laboratory experimental research using spontaneous emulsification method.
Results: Astaxanthin SNEDDS was made in 3 formulations by using the ratio of surfactants and co-surfactants that were characterized to produce a transmittance value of F1 91%, F2 90%, and F3 95%, with a particle size of F1 183.75 nm with a PDI 0.272, F2 195.25 nm with a PDI 0.341, and F3 105.75 nm with a PDI 0.392. The entrapment efficiency (%EE) of Astaxanthine SNEDDS was found to be as follows; F1, F2, and F3 had 94.62, 94.35, and 95.57% EE respectively. The results showed that F3 with a surfactant concentration of 72% and co-surfactant 18% was the best formula in forming SNEDDS.
Conclusion: It can be concluded that the higher the surfactant concentration, the greater its ability to reduce the interfacial tension of the oil droplets so as to obtain small particle sizes and high entrapment efficiency values.

Peer Review History:
Received: 1 May 2022; Revised: 9 June; Accepted: 25 June, Available online: 15 July 2022
Academic Editor: Dr. Nuray Arı, Ankara University, Turkiye, ari@ankara.edu.tr
UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.
Received file: Reviewer's Comments:
Average Peer review marks at initial stage: 5.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Sally A. El-Zahaby, Pharos University in Alexandria, Egypt, sally.elzahaby@yahoo.com
Dr. Mohamed Salama, Modern University for Technology & Information, Egypt, salama47@yahoo.com
Evaluation of Property Investment (Case of Buy or Build Commercial Office Building in Jakarta’s CBD Area)
Authors: Novitasari Juwita , Rahadi Raden Aswin , Rahadi Raden Aswin 
Published: July 2022

Financial security plays an important role in the company’s sustainability. Property is one of the financial security mediums and at the same time also as the investment medium. Not only the medium but also the investment destination is very influential in the result. Therefore, Jakarta as the capital city of Indonesia and as the centre of economic activity has a very big potential market. Jakarta is divided into 5 administrative cities, and CBD as the prime area is located in the golden triangle of Jakarta specifically in South Jakarta.
BPG Corporation is one of the companies based in Jakarta, with the intention to strengthen its financial security. The company assesses by the valuation to investing in a property sector, which faces two choices whether to buy or to build from the ground.
This study will use the Discounted Cash Flow method as the valuation tool to predict the risks, advantages, and weaknesses of the company’s financials. The result is that the buy option is more beneficial to the company with current available equity. IRR of the buy option has ranged from 8% to 13% and the NPV indicates also positive figures.
حروف الجر ومعا نيها في سورة هود
Authors: Muh. Jabir  , Titin Fatimah  , Rezki Awaliyah  
Published: July 2022

Penelitian ini bertujuan untuk mengetahui dan mengkaji jumlah dan makna huruf jarr dalam Al Quran pada surah Hud. Hasil kajian menunjukan bahwa terdapat 251 huruf jarr pada surah Hud, yang terbagi dalam 76 harf min, 26 harf ila, 10 harf ‘an, 36 harf ‘ala, 40 harf fi, 46 harf ba’, 4 harf kaf, dan 13 harf lam.
Effects of Environmental Stresses on the Growth of Arabidopsis thaliana Rosette Leaves
Authors: Jiao Xiang , Peng Chenchen , Zhang Huichun , Huang Zhihui , Zhao Yan 
Published: July 2022

Abstract
Plant growth is constantly affected by biotic and abiotic stresses, which are especially expressed in plant leaves. Therefore, leaf phenotype is considered to be an important indicator of phenotypic plasticity in plants. The effects of various growth environmental factors on the final size of Arabidopsis thaliana rosette leaves and the number of leaves were analyzed in orthogonal tests using image analysis, and growth curves were estimated statistically. Finally, the optimum growth environment for A. thaliana Col-0 was determined. In this study, temperature, humidity, and light intensity were chosen as factors and studied at the three levels each (temperature: 22 °C, 25 °C, 28 °C; humidity: 50%, 65%, 80%; light intensity: 92 μmol·m−2·s−1; 184 μmol·m−2·s−1; 278 μmol·m−2·s−1). The results showed that light intensity was a major factor in the final leaf size, whereas for the number of plant leaves the most important was temperature. According to the major and minor order of environmental factors, the following scheme appeared to be optimal for A. thaliana growth: temperature 22 °C, humidity 50%, illumination intensity 184 μmol·m−2·s−1.
A Spatial Model of Forest Area in the Middle Ages Based on Historical, Archaeological and Geographic Data: A Case Study of 13th-Century Chełmno Land (North-Central Poland)
Authors: Molewski Paweł 
Published: July 2022

Abstract
The settlement established under German law in Chełmno Land in the 13th century, the resultant changes in the structure of agriculture and land cultivation techniques, and the growing demand on wood as timber, fuel and raw materials for crafts, all combined to contribute to the significant deforestation of the territory. The extent of this deforestation remains conjectural. The purpose in creating a model of forest area in 13th-century Chełmno Land was to attempt to reconstruct it and determine its size and, consequently, to verify hypotheses concerning the scale and the ultimate end of deforestation in the research area. The spatial model is based on published historical and archaeological data relating to selected components of the geographical environment that pertain to the forest area. A retrogressive method combined with Multi-Criterion Evaluation (MCE) was used to build a forest area model. The basic platform for collecting, analysing and visualising spatial data was the geographic information system (GIS). The presented estimates indicate that the forest area of Chełmno Land in the 13th century was larger than had previously been assumed, at about 20–25% of the entire territory.
DiRe Committee : Diversity and Representation Constraints in Multiwinner Elections
Authors: Relia Kunal 
Published: July 2022

The study of fairness in multiwinner elections focuses on settings where candidates have attributes. However, voters may also be divided into predefined populations under one or more attributes. The models that focus on candidate attributes alone may systematically under-represent smaller voter populations. Hence, we develop a model, DiRe Committee Winner Determination (DRCWD), which delineates candidate and voter attributes to select a committee by specifying diversity and representation constraints and a voting rule. We analyze its computational complexity and develop a heuristic algorithm, which finds the winning DiRe committee in under two minutes on 63% of the instances of synthetic datasets and on 100% of instances of real-world datasets. We also present an empirical analysis of feasibility and utility traded-off.

Moreover, even when the attributes of candidates and voters coincide, it is important to treat them separately as diversity does not imply representation and vice versa. This is to say that having a female candidate on the committee, for example, is different from having a candidate on the committee who is preferred by the female voters, and who themselves may or may not be female.