bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gachingite, Au(Te1–xSex) 0.2 ≈ x ≤ 0.5, a new mineral from Maletoyvayam deposit, Kamchatka peninsula, Russia
Authors: Tolstykh Nadhezda D. , Tuhý Marek , Vymazalová Anna , Laufek František , Plášil Jakub , Košek Filip 
Published: January 2022

AbstractGachingite, Au(Te1–xSex), 0.2 ≈ x ≤ 0.5, is a new mineral discovered in the Gaching ore occurrence of the Maletoyvayam epithermal deposit, Kamchatka, Russia. Gachingite forms individual droplet-like grains of sizes from 2 to 10 μm included in native gold (Au–Ag), associated with calaverite, maletoyvayamite, watanabeite and Au–Sb oxides. The aggregates do not exceed 100 μm in diameter. In plane-polarised light, gachingite is grey with a bluish tint, has bireflectance (bluish-grey to deep grey), and strong anisotropy with rotation tints blue to dark blue to brown. Reflectance values for gachingite in air (Rmin, Rmax in %) are: 39.9, 40.3 at 470 nm; 41.6, 43.3 at 546 nm; 42.0, 43.7 at 589 nm; and 43.0, 44.0 at 650 nm. Eighteen electron-microprobe analyses of gachingite gave an average composition: Au 62.40, Ag 0.57, Se 9.78, Te 27.33 and S 0.01, total 100.09 wt.%, corresponding to the formula (Au0.96Ag0.02)Σ0.98(Te0.65Se0.37)Σ1.02 based on 2 apfu, the simplified formula is Au(Te0.65Se0.35); the average analyses of its synthetic analogue is Au 65.7, Se 13.1 and Te 21.1, total 99.9 wt.%, corresponding to Au1.00(Te0.50Se0.50). The calculated density is 10.47 g/cm3. The mineral is orthorhombic, space group Cmce (#64) with a = 7.5379 Å, b = 5.7415 Å, c = 8.8985 Å, V = 385.12 Å3 and Z = 8. The crystal structure was solved and refined from the single-crystal X-ray-diffraction data of synthetic Au1.00(Te0.50Se0.50). The crystal structure of gachingite represents a unique structure type, containing linear [Au–Au–Au] chains running along the b-axis indicating strong metallic interaction in one direction. The structural identity of gachingite and its synthetic analogue Au1.00(Te0.50Se0.50) was confirmed by electron back-scatter diffraction and Raman spectroscopy. The formation of gachingite requires an abundant source of Au and Se and a high oxidising environment. Gachingite is related to the gold-bearing productive stage of ore mineralisation, which is stable at 250°C in log$f_{{\rm S}{\rm e}_ 2}$ range of −12.4 and −5.7. The mineral is named after its type locality.
Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans
Authors: Mende Nicole , Bastos Hugo P. , Santoro Antonella , Mahbubani Krishnaa T. , Ciaurro Valerio , Calderbank Emily F. , Quiroga Londoño Mariana , Sham Kendig , Mantica Giovanna , Morishima Tatsuya , Mitchell Emily , Lidonnici Maria Rosa , Meier-Abt Fabienne , Hayler Daniel , Jardine Laura , Curd Abbie , Haniffa Muzlifah , Ferrari Giuliana , Takizawa Hitoshi , Wilson Nicola K. , Göttgens Berthold , Saeb-Parsy Kourosh , Frontini Mattia , Laurenti Elisa 
Published: January 2022

Abstract
Rare hematopoietic stem and progenitor cell (HSPC) pools outside the bone marrow (BM) contribute to blood production in stress and disease but remain ill-defined. Although nonmobilized peripheral blood (PB) is routinely sampled for clinical management, the diagnosis and monitoring potential of PB HSPCs remain untapped, as no healthy PB HSPC baseline has been reported. Here we comprehensively delineate human extramedullary HSPC compartments comparing spleen, PB, and mobilized PB to BM using single-cell RNA-sequencing and/or functional assays. We uncovered HSPC features shared by extramedullary tissues and others unique to PB. First, in contrast to actively dividing BM HSPCs, we found no evidence of substantial ongoing hematopoiesis in extramedullary tissues at steady state but report increased splenic HSPC proliferative output during stress erythropoiesis. Second, extramedullary hematopoietic stem cells/multipotent progenitors (HSCs/MPPs) from spleen, PB, and mobilized PB share a common transcriptional signature and increased abundance of lineage-primed subsets compared with BM. Third, healthy PB HSPCs display a unique bias toward erythroid-megakaryocytic differentiation. At the HSC/MPP level, this is functionally imparted by a subset of phenotypic CD71+ HSCs/MPPs, exclusively producing erythrocytes and megakaryocytes, highly abundant in PB but rare in other adult tissues. Finally, the unique erythroid-megakaryocytic–skewing of PB is perturbed with age in essential thrombocythemia and β-thalassemia. Collectively, we identify extramedullary lineage-primed HSPC reservoirs that are nonproliferative in situ and report involvement of splenic HSPCs during demand-adapted hematopoiesis. Our data also establish aberrant composition and function of circulating HSPCs as potential clinical indicators of BM dysfunction.
Runs of homozygosity in Swiss goats reveal genetic changes associated with domestication and modern selection
Authors: Signer-Hasler Heidi , Henkel Jan , Bangerter Erika , Bulut Zafer ,   The VarGoats Consortium, Drögemüller Cord , Leeb Tosso , Flury Christine 
Published: January 2022

Abstract
Background
The domestication of goat (Capra hircus) started 11,000 years ago in the fertile crescent. Breed formation in the nineteenth century, establishment of herd books, and selection for specific traits resulted in 10 modern goat breeds in Switzerland. We analyzed whole-genome sequencing (WGS) data from 217 modern goats and nine wild Bezoar goats (Capra aegagrus). After quality control, 27,728,288 biallelic single nucleotide variants (SNVs) were used for the identification of runs of homozygosity (ROH) and the detection of ROH islands.

Results
Across the 226 caprine genomes from 11 populations, we detected 344 ROH islands that harbor 1220 annotated genes. We compared the ROH islands between the modern breeds and the Bezoar goats. As a proof of principle, we confirmed a signature of selection, which contains the ASIP gene that controls several breed-specific coat color patterns. In two other ROH islands, we identified two missense variants, STC1:p.Lys139Arg and TSHR:p.Ala239Thr, which might represent causative functional variants for domestication signatures.

Conclusions
We have shown that the information from ROH islands using WGS data is suitable for the analysis of signatures of selection and allowed the detection of protein coding variants that may have conferred beneficial phenotypes during goat domestication. We hypothesize that the TSHR:p.Ala239Thr variant may have played a role in changing the seasonality of reproduction in modern domesticated goats. The exact functional significance of the STC1:p.Lys139Arg variant remains unclear and requires further investigation. Nonetheless, STC1 might represent a new domestication gene affecting relevant traits such as body size and/or milk yield in goats.
Procedural characteristics of pulmonary vein isolation with high-power short-duration setting compared to conventional setting
Authors: Hijioka Naoko , Kaneshiro Takashi , Nehashi Takeshi , Amami Kazuaki , Nodera Minoru , Yamada Shinya , Kamioka Masashi , Ishida Takafumi , Takeishi Yasuchika 
Published: January 2022

Abstract
Purpose
The purpose of this study was to investigate the safety and efficacy of high-power short-duration (HP-SD) ablation compared to conventional ablation in patients with atrial fibrillation (AF).

Methods
We enrolled consecutive 158 drug-refractory symptomatic AF patients (119 males, mean age 63 ± 10 years) who had undergone first radiofrequency pulmonary vein isolation (PVI). PVI was performed using the conventional setting (20–35 W) in 73 patients (Conventional group) and using the HP-SD setting (45–50 W) in 85 patients (HP-SD group). The rate of first pass isolation, remaining gaps after circumferential ablation, dormant conduction, and the radiofrequency application time in each pulmonary vein (PV) were compared between the groups.

Results
The first pass isolation ratio was significantly higher in the HP-SD group than in the Conventional group (81% vs. 65%, P = 0.027) in the right PV, but did not differ in the left PV. The remaining gaps were fewer in the right superior PV (4% vs. 21%, P = 0.001) and left inferior PV (1% vs. 8%, P = 0.032) areas, and the radiofrequency application time in each PV was shorter (right PV, 12.0 ± 8.9 min vs. 34.0 ± 31.7 min, P < 0.001; left PV, 10.6 ± 3.6 min vs. 25.7 ± 22.3 min, P < 0.001) in the HP-SD group than in the Conventional group.

Conclusion
The use of the HP-SD setting might contribute to improve the first pass isolation rate and to shorten the radiofrequency application time in each PV.
Comparison of 3-factor versus 4-factor prothrombin complex concentrate for emergent warfarin reversal: a systematic review and meta-analysis
Authors: Margraf David J. , Brown Sarah J. , Blue Heather L. , Bezdicek Tamara L. , Wolfson Julian , Chapman Scott A. 
Published: January 2022

Abstract
Background
Patients requiring emergent warfarin reversal (EWR) have been prescribed three-factor prothrombin complex concentrate (PCC3) and four-factor prothrombin complex concentrate (PCC4) to reverse the anticoagulant effects of warfarin. There is no existing systematic review and meta-analysis of studies directly comparing PCC3 and PCC4.

Methods
The primary objective of this systematic review and meta-analysis was to determine the effectiveness of achieving study defined target INR goal after PCC3 or PCC4 administration. Secondary objectives were to determine the difference in safety endpoints, thromboembolic events (TE), and survival during the patients’ hospital stay. Random-effects meta-analysis models were used to estimate the odds ratios (OR), and heterogeneity associated with the outcomes. The Newcastle-Ottawa Scale was used to assess study quality, and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed.

Results
Ten full-text manuscripts and five abstracts provided data for the primary and secondary outcomes. Patients requiring EWR had more than three times the odds of reversal to goal INR when they were given PCC4 compared to PCC3 (OR = 3.61, 95% CI: 1.97–6.60, p < 0.001). There was no meaningful clinical association or statistically significant result between PCC4 and PCC3 groups in TE (OR = 1.56, 95% CI: 0.83–2.91, p = 0.17), or survival during hospital stay (OR = 1.34, 95% CI: 0.81–2.23, p = 0.25).

Conclusion
PCC4 is more effective than PCC3 in meeting specific predefined INR goals and has similar safety profiles in patients requiring emergent reversal of the anticoagulant effects of warfarin.
RBD-specific antibody responses after two doses of BBIBP-CorV (Sinopharm, Beijing CNBG) vaccine
Authors: Ferenci Tamás , Sarkadi Balázs 
Published: January 2022

Abstract
Background
Limited information is available on the effectiveness of the BBIBP-CorV (Sinopharm, Beijing CNBG) vaccine, especially in the elderly, despite the fact that it is approved in more than 50 countries.

Methods
RBD-specific antibody titres, as a rapidly available and highly predictive surrogate marker, were measured after two doses of the BBIBP-CorV vaccine in 450 subjects. Results were analyzed in a multivariable model accounting for age, sex and time since the administration of the second dose of the vaccine.

Results
Sex and time since the second dose had little association with the antibody titres. Age, however, was highly relevant: measurable antibody levels were present in about 90% of individuals below the age of 50, but antibody production after BBIBP-CorV vaccination was strongly reduced with increasing age. A large number of elderly subjects, reaching 25% at 60 years, and up to 50% at ages over 80, were found not to produce any protective antibody.

Conclusions
RBD-specific antibody titre, as a correlate of protection for COVID-19 disease susceptibility, should help to evaluate the effectiveness of the BBIBP-CorV vaccine. Results suggest that proper measures should be undertaken to prevent a potential outbreak of COVID-19 in BBIBP-CorV vaccinated but eventually unprotected elderly individuals.
Kearns–Sayre syndrome with a novel large-scale deletion: a case report
Authors: Zhu Qin , Chen Chunwen , Yao Jingyan 
Published: January 2022

AbstractBackgroundKearns–Sayre syndrome (KSS) is a rare, multisystem mitochondrial encephalomyopathy. We report a case of KSS with a novel 7.6-kb deletion as assessed through a long-range polymerase chain reaction (PCR) study in the blood. In addition, optical coherence tomography angiography (OCTA) confirmed deep retinal capillary atrophy for the first time.Case presentationA 13-year-old patient presented with progressive vision loss and difficulty with eye opening and was diagnosed with progressive external ophthalmoplegia and retinitis pigmentosa (RP). The patient also experienced heart block, vestibular dysfunction, growth retardation and multiple demyelinating lesions. A long-range PCR study in the blood revealed a large-scale Chrm: 6341–13,993 deletion, which was first reported and broadened the genetic spectrum of this disease. The patient underwent complete ophthalmic examination, medical history review and gene detection, resulting in a confirmation of the diagnosis of KSS. The patient was given a pair of applicable glasses to wear and was followed up every 3 months. An implantable pacemaker was also installed based on the advice of the physician.ConclusionsWe reported a novel large-scale deletion in the mitochondrial DNA of KSS, and OCTA was used for the first time to confirm deep retinal capillary atrophy. Furthermore, because ophthalmic symptoms are often the primary manifestation of KSS, the relationship between ophthalmology and mitochondrial diseases should be emphasised.
Screening programs for common maternal mental health disorders among perinatal women: report of the systematic review of evidence
Authors: Waqas Ahmed , Koukab Ahmreen , Meraj Hafsa , Dua Tarun , Chowdhary Neerja , Fatima Batool , Rahman Atif 
Published: January 2022

AbstractPostpartum depression and anxiety are highly prevalent worldwide. Fisher et al., estimated the prevalence of depression and anxiety at 15.6% during the antenatal and 19.8% during the postpartum period. Their impact on maternal and child health is well-recognized among the public health community, accounting for high societal costs. The public health impact of these conditions has highlighted the need to focus on the development and provision of effective prevention and treatment strategies.In recent decades, some advances have been made in the development of effective universal and targeted screening programmes for perinatal depression and anxiety disorders. Recent research has shown potential benefits of universal and targeted screening for perinatal depression, to identify and treat undiagnosed cases, and help thwart its deleterious consequences. Ethical implications, however, for these screening programmes, without the provision of treatment have often been emphasized.The present mixed-methods systematic review and meta-analysis was conducted to collate evidence for screening programmes for perinatal depression and anxiety. It aims to answer the following questions, in a global context: For women in the perinatal period, do screening programmes for perinatal depression and anxiety compared with no screening improve maternal mental health and infant outcomes?A series of meta-analyses reveal a reduction in perinatal depression and anxiety among perinatal women undergoing screening programmes. For the outcome of depressive disorder, meta-analysis indicates a positive impact in favour of the intervention group (OR = 0.55, 95% CI: 0.45 to 0.66,n = 9009), with moderate quality of evidence. A significant improvement (high quality) was also observed in symptoms of anxiety among perinatal women (SMD = − 0.18, 95% CI: − 0.25 to − 0.12,n = 3654).
Outdoor public recreation spaces and social connectedness among adolescents
Authors: Rivera Elise , Veitch Jenny , Loh Venurs H. Y. , Salmon Jo , Cerin Ester , Mavoa Suzanne , Villanueva Karen , Timperio Anna 
Published: January 2022

Abstract
Background
Outdoor public recreation spaces are important settings for leisure and physical activity. Adolescents’ use of these spaces may contribute to social connectedness via social interaction with peers and the community in these settings. However, research on this topic is limited. This exploratory study examined associations of frequency of visitation and physical activity in outdoor public recreation spaces with social connectedness among adolescents in Melbourne, Australia.

Methods
Adolescents self-reported their frequency of visitation to parks, trails, beach/lake, and sports facilities; frequency of physical activity in a park, local street or path, and their street; and social connectedness. Separate analyses were conducted for visitation (n = 349, 15.4 ± 1.6 years, 58% female) and physical activity (n = 441, 15.4 ± 1.6 years, 59% female) using multilevel linear regression models.

Results
No significant associations were observed for frequency of visitation to a park (B = 0.86, 95% CI = − 0.26, 1.99), trails (B = 0.41, 95% CI = − 0.61, 1.44), beach/lake (B = − 0.44, 95% CI = − 1.46, 0.57), or sports facilities (B = 0.64, 95% CI = − 0.43, 1.70), nor for frequency of physical activity in their street (B = − 0.07, 95% CI = − 0.46, 0.31), local street/path (B = − 0.05, 95% CI = − 0.43, 0.33) or in a park (B = 0.23, 95% CI = − 0.14, 0.60) with adolescents’ social connectedness.

Conclusions
The findings did not support the hypothesis that visiting and being active in outdoor public recreation spaces are associated with adolescents’ social connectedness. Future research should consider the duration and context of outdoor public recreation space use (e.g., sports, socialising, relaxing alone) and whether different types and/or a combination of public spaces are more/less conducive to social connectedness.
Modernising grip dynamometry: Inter-instrument reliability between GripAble and Jamar
Authors: Mutalib Sharah Abdul , Mace Michael , Seager Chloe , Burdet Etienne , Mathiowetz Virgil , Goldsmith Nicola 
Published: January 2022

Abstract
Introduction
Maximum grip strength (MGS) is a reliable biomarker of overall health and physiological well-being. Therefore, an accurate and reliable measurement device is vital for ensuring the validity of the MGS assessment. This paper presents GripAble, a mobile hand grip device for the assessment of MGS. GripAble’s performance was evaluated using an inter-instrument reliability test against the widely used Jamar PLUS+ dynamometer.

Methods
MGS data from sixty-three participants (N = 63, median (IQR) age = 29.0 (29.5) years, 33 M/30 F) from both hands using GripAble and Jamar PLUS+ were collected and compared. Intraclass correlation (ICC), regression, and Bland and Altman analysis were performed to evaluate the inter-instrument reliability and relationship in MGS measurements between GripAble and Jamar PLUS+ .

Results
GripAble demonstrates good-to-excellent inter-instrument reliability to the Jamar PLUS+ with ICC3,1 = 0.906 (95% CI [0.87—0.94]). GripAble’s MGS measurement is equivalent to 69% (95% CI [0.67—0.71]%) of Jamar PLUS+’s measurement. There is a proportional difference in mean MGS between the two devices, with the difference in MGS between GripAble and Jamar PLUS+ increasing with MGS.

Conclusion
The GripAble is a reliable tool for measuring grip strength. However, the MGS readings from GripAble and Jamar PLUS+ should not be interchanged for serial measurements of the same patient, nor be translated directly from one device to the other. A new normative MGS data using GripAble will be collected and accessed through the software for immediate comparison to age and gender-matched subpopulations.
Evaluating the implementation of home delivery of medication by community health workers during the COVID-19 pandemic in Cape Town, South Africa: a convergent mixed methods study
Authors: Mash Robert James , Schouw Darcelle , Daviaud Emmanuelle , Besada Donela , Roman Darrin 
Published: January 2022

Abstract
Background
Primary care services in South Africa have been challenged by increasing numbers of people with communicable and non-communicable chronic diseases. There was a need to develop alternative approaches for stable patients to access medication. With the onset of the coronavirus pandemic there was an urgent need to decongest facilities and protect people from infection. In this crisis the Metro Health Services rapidly implemented home delivery of medication by community health workers. This study aimed to evaluate the implementation of home delivery of medication by community health workers during the coronavirus pandemic in Cape Town, South Africa.

Methods
A convergent mixed methods study evaluated six implementation outcomes: adoption, feasibility, fidelity, coverage, cost, and sustainability of the initiative. Data sources included routinely collected data, a telephonic survey of 138 patients, an analysis of set-up and recurrent costs as well as 17 descriptive exploratory qualitative semi-structured interviews with 68 key informants.

Results
Over a 6-month period 1,054,657 pre-packaged parcels were sent to primary care facilities, 819,649 (77.7%) were delivered and of those 97,297 (11.9%) returned. The additional costs were estimated as 1.3% of a total health budget of R2,2 billion. The initiative was rapidly adopted as it decongested facilities and protected vulnerable patients. Although it was feasible to implement at scale, numerous challenges were encountered, such as incorrect addresses and contact details, transporting parcels, communicating with patients, having a reliable audit trail, and handling out-of-area patients. All role players thought the service should continue and 42.3% of patients reported better adherence to their medication.

Conclusion
Home delivery of medication by community health workers is feasible at scale and affordable. It should continue, but as one of a menu of options for alternative delivery of medication. The following need to be improved: efficiency of the system, the audit trail, adequate support and resources for community health workers, transport of medication, communication with patients, empanelment of patients, governance of the system and training of the community health workers.
Plasma sRAGE levels strongly associate with centrilobular emphysema assessed by HRCT scans
Authors: Klont Frank , Horvatovich Peter , Bowler Russell P. , van Rikxoort Eva , Charbonnier Jean-Paul , Kwiatkowski Marcel , Lynch David A. , Humphries Stephen , Bischoff Rainer , ten Hacken Nick H. T. , Pouwels Simon D. 
Published: January 2022

Abstract
Background
There is a strong need for biomarkers to better characterize individuals with COPD and to take into account the heterogeneity of COPD. The blood protein sRAGE has been put forward as promising biomarker for COPD in general and emphysema in particular. Here, we measured plasma sRAGE levels using quantitative LC–MS and assessed whether the plasma sRAGE levels associate with (changes in) lung function, radiological emphysema parameters, and radiological subtypes of emphysema.

Methods
Three hundred and twenty-four COPD patients (mean FEV1: 63%predicted) and 185 healthy controls from the COPDGene study were selected. Plasma sRAGE was measured by immunoprecipitation in 96-well plate methodology to enrich sRAGE, followed by targeted quantitative liquid chromatography-mass spectrometry. Spirometry and HRCT scans (inspiration and expiration) with a 5-year follow-up were used; both subjected to high quality control standards.

Results
Lower sRAGE values significantly associated with the presence of COPD, the severity of airflow obstruction, the severity of emphysema on HRCT, the heterogeneous distribution of emphysema, centrilobular emphysema, and 5-year progression of emphysema. However, sRAGE values did not associate with airway wall thickness or paraseptal emphysema.

Conclusions
Rather than being a general COPD biomarker, sRAGE is especially a promising biomarker for centrilobular emphysema. Follow-up studies should elucidate whether sRAGE can be used as a biomarker for other COPD phenotypes as well.