bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wood‐Biochar Influence on Rill Erosion Processes and Hydrological Connectivity in Amended Soils
Authors: Conte Pellegrino , Librici Calogero , Nicosia Alessio , Palmeri Vincenzo , Pampalone Vincenzo , Ferro Vito 
Published: February 2025

ABSTRACTAlthough there is increasing interest in biochar as a soil amendment, its antierosive effectiveness is still uncertain. This investigation aims at evaluating how wood‐biochar affects rill erosion and hydrological connectivity in amended soils. In this paper, at first, plot experiments were performed entering a clear inflow into two rills, named rill3 and rill5, incised in a soil amended with an initial biochar concentration BC in weight of 3% and 5%, respectively. For each rill, terrestrial photogrammetry was used to obtain the Digital Elevation Models (DEM) before and after the experimental runs, and the consequent DEM of difference (DoD) was used to calculate the total volume of the eroded mixture (sediment and biochar), while three samples of rill outflow discharge were collected to determine the biochar and sediment rates. Then, small laboratory samples of the soil, biochar, and mixtures with different BC (1%, 3%, 5%, 10%, and 30%) were used to determine size and distribution of pores, and thus measure the structural and functional connectivity, by nuclear magnetic resonance (NMR) relaxometry with the fast field cycling (FFC) layout. The DoDs highlighted that the mixture volume for rill5 was lower than that for rill3. Moreover, the rill5 condition yielded a higher biochar percentage in the mixture. The NMR measurements demonstrated that the biochar addition increases the size of micropores and mesopores, and the macro‐pore component is never dominant. Biochar concentrations greater than 5% do not produce appreciable changes in the pore distribution inside the mixture. The biochar component improves the structural connectivity up to BC = 5%. In the BC range of 0%–3%, FCI decreased as BC increased. In conclusion, a target biochar concentration of 5% allows for the mitigation of the rill erosion phenomena, favours the improvement of soil structural connectivity, and does not appreciably modify the functional connectivity.
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Authors: Wong Man‐Kei , Loh Jian Yiing , Yap Feng Ming , Ong Wee‐Jun 
Published: February 2025

The cover art, prepared by Ong's group at Xiamen University Malaysia, showcases the advancement and application of layered double hydroxides (LDHs) and other cutting‐edge electrocatalysts, driving the transition to a net‐zero future. The train symbolizes the momentum towards renewable fuels powered by next‐generation electrochemical energy conversion and storage technologies. This captivating journey highlights the development of robust, advanced electrocatalysts that tackle environmental challenges while generating value‐added energy products.
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Circ_0070934 Regulates the Proliferation, Metastasis, and Epithelial–Mesenchymal Transition of Colorectal Cancer Cells by Targeting miR‐203a‐3p/HOXA13 Axis
Authors: Zhang Xin , Lei Changjiang , Lu Hongxia , Kang Biao , Liu Maoxi , Jiang Huiyuan , Zan Likun 
Published: February 2025

ABSTRACTThe present work explored the functions of circ_0070934 in regulating malignant phenotype of colorectal cancer (CRC) cells and its underlying mechanisms. Gene expression data set was acquired based on Gene Expression Omnibus (GEO) database for examining circ_0070934 levels within CRC cells and tissues through quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR). Kaplan–Meier curve and log‐rank test were adopted for assessing CRC patient prognosis based on circ_0070934 level. Functional assays including Cell Counting Kit (CCK)‐8, EdU incorporation, Transwell invasion, and scratch assays were conducted to determine CRC cell malignancy. Molecular interactions were predicted using circInteractome and StarBase databases, and validated through luciferase reporter assay. Circ_0070934 was upregulated within CRC cells and tissues, which was related to a dismal prognostic outcome in CRC patients. Knocking down circ_0070934 inhibited CRC cell proliferation, epithelial–mesenchymal transition (EMT), and migration. Further, we identified miR‐203a‐3p as a target miRNA of circ_0070934, and miR‐203a‐3p negatively regulated Homeobox A13 (HOXA13) expression. miR‐203a‐3p/HOXA13 axis mediates the function of circ_0070934 in modulating CRC cell malignancy. These data revealed that circ_0070934 was important for maintaining the malignant phenotype of CRC cells, and circ_0070934 knockdown undermined CRC cell malignancy. Targeting circ_0070934/miR‐203a‐3p/HOXA13 axis is the promising intervention approach for managing CRC.
CID‐Induced Formation of Deprotonated Cyclic Peptide Ions From Anionic Adducts
Authors: Modzel Maciej , Stefanowicz Piotr 
Published: February 2025

ABSTRACTMS analysis of cyclic peptides in negative ion mode has been a challenge, in particular if the peptide does not contain acidic functional groups. In this paper, we present a way to easily produce negative ions from anionic peptide adducts, utilising collision‐induced dissociation (CID)‐mediated elimination. Using two different mass spectrometers, we have generated series of adducts of three cyclic and one linear peptide with various anions. They were then isolated and subjected to CID with a range of collision energies. The deprotonation percentage was then calculated from the resultant spectrum, and compared between the spectrometers, as well as with an external reference—proton affinity values. The susceptibility to deprotonate by detaching a HX moiety is proportional to the proton affinity of the X− species. Also, the linear peptide deprotonated more readily than the cyclic ones. On the other hand, lack of amino or acidic groups resulted in higher collision voltage (CV) necessary for the formation of deprotonated species. Moreover, the exact propensity for neutral loss depends on the ion temperature, which differs between mass spectrometers. We have developed a facile method for generating peptide anions for MS analysis of cyclic peptides, which works even if the peptide in question does not have easily ionisable groups. The deprotonated species generated in this way can be fragmented again in order to identify the peptide.
Integrated Seroprevalence and Genome‐Based Study of SARS‐CoV‐2 Viral Strains in N′Djamena: Insights Into Chad's COVID‐19 Epicenter
Authors: Hota Mathiew , Wondeu Andrillene L. D. , Abakar Mahamat F. , Dezoumbe Koutaya , Abdelrazakh Fatima , Atturo Sabrina , Naïbeï Nathan , Cappelli Giulia , Mennechet Franck , Yandai Fissou H. , Abdallah Djamal H. , Edgard Zongo R. F. , Boukar Abdoulaye , Moussa Choroma A. , Yaya Issa M. , Hamad Mahamat I. , Armand Nontegyol , Honorine Netalar , Frederic Kayanlengar , Moustapha Adam A. , Daniel Yanda M. , Alim Adam M. , Grene Mahamat , Djarma Oumaima , Suitombaye Noubaramadji Y. , Akouya Amine , Choua Ouchemi , Dzomo Guy R. T. , Djimtoïbaye Djallaye , Colizzi Vittorio , Moussa Mahamat A. , Giovanetti Marta 
Published: February 2025

ABSTRACTThe COVID‐19 epidemic has shown regional variations in transmission and outcomes. As a primary hotspot in Chad, N'Djamena is crucial for comprehensive epidemiological investigation. Our study employed two methodologies: seroprevalence data collection and whole‐genome sequencing of SARS‐CoV‐2 strains. This dual approach assessed population exposure and virus genetic diversity. Seroprevalence data indicated broader exposure than confirmed cases suggested, and genome sequencing identified multiple strains, including globally recognized variants of concern. Integrating these data provided insights into transmission dynamics, potential herd immunity thresholds, and the impact of specific variants on disease progression. Our findings underscore the importance of integrated, multidisciplinary research in infectious disease epidemiology and inform targeted public health strategies, including social measures and vaccination, to combat infectious diseases in N'Djamena.
Clinical Characteristics and Severity Predictors of Pediatric Adenovirus Infections
Authors: Ho Sheng‐Yuan , Zhou Yu‐Ting , Ho Shu‐Yuan , Hu Ya‐Li , Yen Ting‐Yu , Huang Kuan‐Ying A. , Lu Chun‐Yi , Huang Li‐Min , Chang Luan‐Yin 
Published: February 2025

ABSTRACTAdenovirus infections impose a significant disease burden on children and can result in poor clinical outcomes, thus requiring intensive care and potentially leading to fatality. We retrospectively analyzed pediatric adenovirus cases from 2018 to 2023 at a children's hospital in Taiwan and collected data regarding patients' clinical symptoms, imaging results, and laboratory findings. Multiple logistic regression was used to identify predictors of severe cases requiring intensive care. Our study revealed that adenovirus cases were more common in the winter, with a post‐COVID‐19 surge observed in 2023. A total of 576 pediatric adenovirus cases were collected, including 27 (4.7%) severe cases and 3 (0.5%) fatal cases. Severe cases were younger and exhibited higher frequencies of dyspnea, decreased activity, and diagnoses of bronchopneumonia/pneumonia and genetic disorders. Compared with nonsevere cases, severe cases also demonstrated more patchy opacity, lobar consolidation, pleural effusion, and bacterial coinfection. Multivariable analysis revealed that the most significant predictors of severe cases were dyspnea (aOR 18.5 [95% CI 3.792–90.257]), patchy opacity (3.391 [1.150–9.994]), lobar consolidation (116.388 [8.555–1583.393]), pleural effusion (9.117 [0.917–90.630]), and invasive bacterial coinfection (60.469 [4.047–903.555]), which are newly recognized predictors, thus highlighting the need for increased clinical vigilance.
Evaluation of fecal neutrophil gelatinase‐associated lipocalin levels in childhood inflammatory bowel disease
Authors: Kardas Yildiz Aysenur , Urganci Nafiye , Usta Ayşe Merve 
Published: February 2025

AbstractObjectivesInflammatory bowel disease (IBD) is an immune‐mediated, chronic, remitting, and relapsing disease. Calprotectin, used in monitoring the disease activity, is expressed from neutrophilic granulocytes during inflammation. Neutrophil gelatinase‐associated lipocalin (NGAL) is strongly expressed in both granulocytes and the intestinal epithelial cell layer. The aim of the study was to compare fecal NGAL (FNGAL) with fecal calprotectin (FCAL) in children with IBD.MethodsForty‐four children with IBD and 22 healthy children were included in the study. The patients were divided into two groups, patients with active disease and remission group. Clinical and demographic characteristics, disease activity scores, and serum and fecal markers of the patients were recorded.ResultsThe mean age of the patients was 13.2 ± 3.4 years (range 6–17 years) and male/female: 0.62. FNGAL levels of patients with active disease were higher than those in the remission group (p < 0.001). A statistically significant positive correlation was observed between Pediatric Ulcerative Colitis Activity Index scores and white blood cell count, platelets, neutrophil‐to‐albumin ratio (NAR), erythrocyte sedimentation rate (ESR), C‐reactive protein (CRP), and FNGAL. There was a positive correlation between Pediatric Crohn's Disease Activity Index scores and platelets, NAR, ESR, CRP, and FNGAL, whereas there was a statistically significantly negative correlation with activity scores and albumin. While FNGAL had 95.5% sensitivity and 81.8% specificity, FCAL had 86.7% sensitivity and 85.7% specificity.ConclusionsFNGAL levels were found to be high and sensitive in determining disease activity in our patients with IBD, suggesting that it may be a valuable biomarker.
Contemporary Surgical Approaches in Managing Laryngeal Chondrosarcoma: A Scoping Review
Authors: Cronkite D. Alexander , Moffatt Clare , Tam Kenric , Yu Alice C. , Chhetri Dinesh K. , St. John Maie 
Published: February 2025

ABSTRACTObjectiveThe aim of this scoping review is to describe and evaluate current surgical management options for chondrosarcoma of the larynx, and to summarize these techniques with respect to the laryngeal subsite affected.Data SourcesPubMed/MEDLINE and EMBASE databases.Review MethodsThe review was conducted according to the Preferred Reporting Items for Systematic Reviews extension for Scoping Reviews.ResultsForty‐one articles met eligibility criteria for inclusion in the final analysis, which included a total of 149 unique surgical cases that were analyzed based on affected laryngeal subsites of cricoid, thyroid, arytenoid, and epiglottis. Management of cricoid chondrosarcoma favored transoral endoscopic resection (TER) or transcervical laryngeal preservation surgery (TPLS), which ranged from limited tumor debulking via laryngofissure to larger operations like subtotal to total cricoidectomy with laryngeal reconstruction. Nearly all cases of arytenoid and epiglottic chondrosarcoma were successfully managed with TER techniques. Thyroid chondrosarcoma primarily affected the outer cortex of the cartilage and very rarely involved the endolaryngeal mucosa, making it very amenable to transcervical approaches to remove part of or the entire affected thyroid lamina.ConclusionOverall trends in the articles reviewed for this study suggest that more aggressive surgery and R0 resection did not lead to better overall survival, which aligns with the broader philosophical shift in treatment goals to prioritize preservation of the larynx and laryngeal function over complete oncologic resection.Level of EvidenceN/A.
YOU ARE THE LEADER YOU ARE SEEKING
Authors: Solis Brian 
Published: February 2025

AbstractThe author, Head of Global Innovation at ServiceNow, discusses the concept of a mindshift, which he says “refers to a transformative change in thinking and approach, particularly in response to the 21st Century’s fast‐evolving business landscape and the need for continuous innovation.” He contends that “team members who lead change have and will continue to come from all levels of organizations, often far beyond the C‐Suite.” He further notes that “effective change agents collectively describe themselves as problem‐solvers and critical thinkers. But they also differ in some traits. For example, some strongly identify as extroverts, others quiet introverts.” In learning how to earn and exert influence within their organizations, he found that change agents “formed strategic alliances, focusing on managing their teams well and building relationships with key decision‐makers, eventually including those at the executive level, even those in the C‐suite.” He also relates the importance of self‐awareness and empathy, citing research carried out by organizational psychologist Tasha Eurich, and behavioral statistician Joseph Folkman. And the author makes the provocative contention that “it may sound cliché, but the essential difference between those who change the world and those who get stuck is that the changemakers take the first step and then the next and continue to forge ahead.”
Assessing Plasma APLP1 for the Progression of Parkinson's Disease: Insights from HSPD and PPMI Cohorts
Authors: Ni You , Yin Ya‐Nan , Yu Wen‐Bo , Liu Yi‐Qi , Zhao Jue , Yan Yu‐Chen , Zhao Wan‐Bing , Tang Yi‐Lin , Sun Yi‐Min , Liu Feng‐Tao , Ran Peng , Wu Jian‐Jun , Ding Chen , Wang Jian 
Published: February 2025

AbstractBackgroundAmyloid precursor‐like protein 1 (APLP1) is involved in pathological α‐synuclein transmission, but its role in Parkinson's disease (PD) progression has not been explored.ObjectiveThis study investigates APLP1 as a potential predictor for motor and cognitive deterioration in PD.MethodsPlasma APLP1 levels were measured in PD patients from the Huashan Hospital for Parkinson's Disease (HSPD) and Parkinson's Disease Progression Markers Initiative (PPMI) cohorts. A total of 916 participants were recruited in the HSPD cohort, and 171 participants were in the PPMI cohort. Longitudinal analysis examined the association between baseline APLP1 levels and PD progression.ResultsA significant increase in APLP1 levels was observed in PD patients compared to healthy controls. Longitudinal analysis showed that patients with elevated baseline APLP1 levels experienced faster motor deterioration in HSPD cohort (HR = 3.627, P < 0.0001).ConclusionsThe data indicate that APLP1 is associated with the progression of PD, potentially offering a measurable indicator of disease progression. © 2025 International Parkinson and Movement Disorder Society.
Catalysis Science in China: From Traditional Techniques to Modern Innovations
Authors: Li Zhiliang , Fu Xianbiao 
Published: February 2025

ABSTRACTAs a recipient and learner of modern sciences, China has made significant strides in catalysis research and application over the past century and a half. Starting in the late Qing Dynasty, the country started to accumulate extensive experience in employing catalytic technologies to produce essential materials such as sulfuric acid and synthetic ammonia, which were mainly shipped into China from abroad in the past. The product list gradually expanded. In recent years, however, China has become one of the global leaders in modern catalysis research by establishing key concepts and theories, as well as developing cutting‐edge technologies in various fields, such as confinement catalysis, single‐atom catalysis, chiral catalysis, the Sabatier principle of metal‐support interaction, modern characterization methods, and clean energy catalysis.
Research progress on highly conductive polymer composites based on carbon‐based nanofillers
Authors: Guohua Lou , Zhiyong Zhao , Yangang Wang 
Published: February 2025

AbstractPolymer conductive composites have attracted significant attention in materials science due to customizable properties, corrosion resistance, lightweight nature, excellent processability, and low cost, which have increasingly extensive applications in electronics, aerospace, and energy devices. However, the relatively low electrical conductivity of polymer composites with carbon‐based nanofillers restricts their use in highly conductive applications. Over the past few decades, considerable research has been directed towards enhancing the electrical conductivity of these composites. This review highlights recent advancements in the development of highly conductive polymer composites, focusing on strategies such as segregated conductive networks, multiphase blending, and pre‐constructed 3D conductive networks. The benefits and current challenges of these methods are discussed. Additionally, the paper summarizes the practical applications of highly conductive polymer composites with carbon‐based nanofillers in various high‐conductivity fields. This review offers valuable insights for the preparation of next‐generation conductive polymer composites tailored for diverse high‐conductivity applications.Highlights
Comprehensive strategies for enhancing conductivity in CPCs are thoroughly reviewed.
Explores applications in fuel cell plates, EMI shielding, and conductive adhesives.
Future research trends and challenges are critically discussed.
Evaluating in‐plane shear properties of bamboo textile‐reinforced polymer using the Iosipescu, V‐notch rail shear, and ±45° laminate tension tests
Authors: Chang Chun‐Wei , Li Shyue‐Cheng , Tang Zhu‐Min , Chang Feng‐Cheng 
Published: February 2025

AbstractIn this study, the in‐plane shear behavior of bamboo textile‐reinforced polymer with twill 2/2 structure were evaluated using the Iosipescu, V‐notched rail tension, and ± 45° laminate tension tests. We analyzed the behavior of the polymer under various shear strains and loading conditions in these tests using various strain measurement tools, including digital image correlation. We discovered that the shear modulus and shear strength varied significantly depending on the loading modes and testing methods. The in‐plane shear modulus G12 (or GLT) values (1.94–1.25 GPa) differed among the three tests because of the different loading modes, load response characteristics, and fracture modes of the matrix and bamboo. The rail test conducted in the tension loading mode produced the ideal contours of pure in‐plane shear. We also found that the size of the woven unit relative to the gauge length plays a critical role in determining the stability of the measured strain value. This study validated the influence of loading mechanisms and structural characteristics on the measured shear properties of the biocomposite materials.Highlights
In‐plane shear obtained using three distinct test methods
G12 of bamboo‐reinforced polymer is 1.94–1.25 GPa
Loading modes affect shear modulus and strength
Woven unit size crucial in measuring shear strain
Evaluation of impact resistance of sustainable sandwich structures with optimized FDM core geometries using low‐velocity drop impact tests
Authors: Kalaimagal S. , Vasumathi M. , Rashia Begum S. , Saravana Kumar M. , Romanovski Valentin , Salah Bashir 
Published: February 2025

AbstractSandwich structures have gained considerable attention in engineering due to their lightweight nature and excellent mechanical properties. However, their impact resistance has been a critical limitation. This research addresses this challenge by enhancing the impact resistance of sandwich structures through the integration of fused deposition modeling (FDM) with glass fiber‐reinforced polylactic acid (PLA + GF) composites. Three core geometries trihexagonal, hexagonal, and triangular are 3D printed using FDM technology, while the facing sheets, made of unidirectional Kevlar fiber and an aluminum layer, provide superior impact resistance, energy absorption, and corrosion resistance. The complete sandwich structures are fabricated using a hand layup process and subjected to low‐velocity drop impact tests for evaluation. The study aims to develop lightweight yet high‐strength materials, particularly for bumper applications, by analyzing the mechanical properties of these sandwich structures. Among the tested designs, the trihexagonal core demonstrated the highest peak force, approximately 4000 N at a height of 600 mm and 4500 N at 1100 mm, highlighting its exceptional stiffness and efficient energy dissipation due to uniform impact load distribution. Additionally, the contact time analysis revealed contrasting behaviors: the triangular core reached its peak force the fastest, at 0.514 ms at 600 mm, indicating a brittle and rapid response, while the hexagonal core had the longest contact time of 2.14 ms, showcasing gradual deformation and superior energy absorption. The findings contribute valuable insights for advancing high‐performance materials in various engineering applications, where both strength and lightweight characteristics are crucial.Highlights
GF‐reinforced PLA composites were used as a core for sandwich structure.
FDM was equipped to print hexagonal, trihexagonal and triangular core.
Aluminum facing sheet and Kevlar fiber aids in improving impact resistance.
Trihexagonal core shows the optimal balance of recovery under dynamic loading.
An improved variant of tobacco etch virus (TEV) protease that does not need reducing agents
Authors: Davis Stella M. , Romig Bryn L. , Abe Alyssa A. , Loening Nikolaus M. 
Published: February 2025

AbstractHere we show that a combination of previously suggested mutations for tobacco etch virus (TEV) protease results in a TEV protease mutant that maintains the same catalytic efficiency as previously described mutants but has enhanced stability and solubility. Another advantage of this new variant of TEV protease is that it does not need the inclusion of a reducing agent to maintain its effectiveness, making it easier to generate, store, and use in cleavage reactions compared to previous TEV protease mutants and, in particular, makes it a good choice for cleaving proteins that contain disulfide bonds that would otherwise be altered by the inclusion of a reducing agent. We also provide a straightforward purification protocol for generating this new version of TEV protease.