bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of an Adipofascial Superficial Circumflex Iliac Artery Perforator Flap to Improve Contour Following Resection of Upper Extremity Amniotic Band Constriction: A Report of Two Patients
Authors: MALLARINO Gonzalo , FOTI-BARRETO José Rodrigo , GUTIERREZ Carlos David , ROMERO-BARRETO Camilo 
Published: February 2022

Amniotic band syndrome (ABS) is a congenital disease that causes a variable degree of deformity and tissue disruption. Surgical excision of fibrotic tissue and advancement of local flaps is the gold standard for constriction bands of the upper limb. We report the use of an adipofascial Superficial Circumflex Iliac Artery perforator (SCIP) flap to improve contour following amniotic band resection in the upper extremity in two patients with ABS. The use of this microsurgical technique can be considered in the occasional patient when there is a deficit of soft tissues after release of the contracture band that cannot be addressed with locally available tissue.
Fome, lama e caos: a presença dos homens-caranguejo no estuário poético de Chico Science & Nação Zumbi
Authors: Feitosa George Antonio , Martins Edson Soares 
Published: February 2022

Com o lançamento de Da lama ao caos (1994), álbum de estreia da banda recifense Chico Science & Nação Zumbi, a ascensão artística do movimento Manguebit expôs amplamente sua proposta interestética de aproximar harmonicamente diferentes expressões artísticas. Chico Science, valendo-se desta proposta, constrói o conceito dos Homens-caranguejo, com base na obra Homens e caranguejos (1967), do também recifense Josué de Castro, para complementar a atmosfera plural de sua música. Pretendemos aqui explorar essa aproximação entre Science e Castro, procurando identificar e analisar suas referências, valendo-nos da visão bakhtiniana presente em “O problema do conteúdo, do material e da forma na criação literária” (2010) e A cultura popular na Idade Média e no Renascimento: o contexto de François Rabelais / Mikhail Bakhtin (1987).
Imaging and Surveillance of Chronic Aortic Dissection: A Scientific Statement From the American Heart Association
Authors: Fleischmann Dominik , Afifi Rana O. , Casanegra Ana I. , Elefteriades John A. , Gleason Thomas G. , Hanneman Kate , Roselli Eric E. , Willemink Martin J. , Fischbein Michael P. ,   on behalf of the American Heart Association Council on Cardiovascular Radiology and Intervention; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Clinical Cardiology; and Council on Cardiovascular Surgery and Anesthesia
Published: February 2022

All patients surviving an acute aortic dissection require continued lifelong surveillance of their diseased aorta. Late complications, driven predominantly by chronic false lumen degeneration and aneurysm formation, often require surgical, endovascular, or hybrid interventions to treat or prevent aortic rupture. Imaging plays a central role in the medical decision-making of patients with chronic aortic dissection. Accurate aortic diameter measurements and rigorous, systematic documentation of diameter changes over time with different imaging equipment and modalities pose a range of practical challenges in these complex patients. Currently, no guidelines or recommendations for imaging surveillance in patients with chronic aortic dissection exist.
In this document, we present state-of-the-art imaging and measurement techniques for patients with chronic aortic dissection and clarify the need for standardized measurements and reporting for lifelong surveillance. We also examine the emerging role of imaging and computer simulations to predict aortic false lumen degeneration, remodeling, and biomechanical failure from morphological and hemodynamic features. These insights may improve risk stratification, individualize contemporary treatment options, and potentially aid in the conception of novel treatment strategies in the future.
Herman and Johan Herman Bavinck on the Uniqueness of Christian Theism
Authors: Shannon Nathan D. 
Published: February 2022

Abstract
This article presents Herman Bavinck and Johan Herman Bavinck’s explications of the uniqueness of Christian theism in terms of the absolute personalism of the Christian Scriptures. Both argue that, outside of Christian special revelation, absoluteness and personality appear in irresolvable dialectic. The dogmatician Herman Bavinck detects this tension in the history of Western philosophy, and the missiologist Johan Herman in the religions of Java. They argue that the Christian Scriptures present the absolute personality of the triune God as the subversive fulfillment of the contradictory theisms of philosophical speculation and of non-Christian religions respectively. This article thus attempts a retrieval of a promising neo-Calvinist theme for the sake of a Reformed theology of religions and missiological encounter.
Constitutional Breakdowns in Revolutionary Outbreaks: A Legal Analysis and Political Reinterpretation of Mubarak’s Fall
Authors: Blouët Alexis 
Published: February 2022

Abstract
It is not self-evident to associate revolution with law. The disruption of political order that usually underlies revolutionary outbreaks is thought to affect legal rules so that they are no longer orienting actors. However, if law might be a source of constraints, ontologically it is more surely a discursive register tied to a state’s legitimacy. When the state’s control is at stake, as in a revolutionary situation, one can therefore understand that actors pay attention to the legal significance of their actions. The article will draw on this to analyze the Egyptian army’s arrival to power and Mubarak’s departure during the Revolution of 25 January 2011. By framing their acts as ruptures with constitutional legality (constitutional breakdowns), the article will suggest a richer and more nuanced narrative to the one commonly put forth by the literature. It will point to institutional strategies likely underpinning both actors’ decisions and show that the army’s initial intervention and Mubarak’s resignation might have been less definitive at the time. It will also suggest new ways to think about the relation between law and revolutionary politics. By drawing notably on an understanding of law as a system of meaning from which actors make sense of events and act on them, it will show that legal studies can shed light on revolutionary moments beyond the issue of revolutionary processes’ institutionalization.
Hyperacute prediction of functional outcome in spontaneous intracerebral haemorrhage: systematic review and meta-analysis
Authors: Hammerbeck Ulrike , Abdulle Aziza , Heal Calvin , Parry-Jones Adrian R 
Published: February 2022

Purpose To describe the association between factors routinely available in hyperacute care of spontaneous intracerebral haemorrhage (ICH) patients and functional outcome. Methods We searched Medline, Embase and CINAHL in February 2020 for original studies reporting associations between markers available within six hours of arrival in hospital and modified Rankin Scale (mRS) at least 6 weeks post-ICH. A random-effects meta-analysis was performed where three or more studies were included. Findings Thirty studies were included describing 40 markers. Ten markers underwent meta-analysis and age (OR = 1.06; 95%CI = 1.05 to 1.06; p < 0.001), pre-morbid dependence (mRS, OR = 1.73; 95%CI = 1.52 to 1.96; p < 0.001), level of consciousness (Glasgow Coma Scale, OR = 0.82; 95%CI = 0.76 to 0.88; p < 0.001), stroke severity (National Institutes of Health Stroke Scale, OR=1.19; 95%CI = 1.13 to 1.25; p < 0.001), haematoma volume (OR = 1.12; 95%CI=1.07 to 1.16; p < 0.001), intraventricular haemorrhage (OR = 2.05; 95%CI = 1.68 to 2.51; p < 0.001) and deep (vs. lobar) location (OR = 2.64; 95%CI = 1.65 to 4.24; p < 0.001) were predictive of outcome but systolic blood pressure, CT hypodensities and infratentorial location were not. Of the remaining markers, sex, medical history (diabetes, hypertension, prior stroke), prior statin, prior antiplatelet, admission blood results (glucose, cholesterol, estimated glomerular filtration rate) and other imaging features (midline shift, spot sign, sedimentation level, irregular haematoma shape, ultraearly haematoma growth, Graeb score and onset to CT time) were associated with outcome. Conclusion Multiple demographic, pre-morbid, clinical, imaging and laboratory factors should all be considered when prognosticating in hyperacute ICH. Incorporating these in to accurate and precise models will help to ensure appropriate levels of care for individual patients.
All Epiphyseal ACL Reconstruction in Skeletally Immature Patients Using Quadriceps Tendon Autograft
Authors: Yalcin Sercan , Maier Jacob , Saluan Paul 
Published: February 2022

Background: The incidence of anterior cruciate ligament (ACL) tear in the skeletally immature pediatric population has been steadily increasing due to multiple factors, including multiple sports participation, year-round training, and the increase in the number of athletes. Reconstruction in these patients is challenging due to the open physes at the distal femur, proximal tibia, and tibial tuberosity apophysis. Violation of the physis can result in angular deformities or leg length discrepancies. Indications: To demonstrate steps of all epiphyseal ACL reconstruction in skeletally immature patients using quadriceps tendon autograft. Technique Description: After the patient is positioned, prepped, and draped, the quadriceps tendon autograft is harvested and prepared to be used as the autograft. Using the all-inside technique, femoral and tibial tunnels are created as all-epiphyseal to prevent violating the physes. The ends of the graft are then passed through the tunnels and fixed with an adjustable loop on the femur and a button on the tibia. Results: Although excellent clinical outcomes and a high return to sports rates have been reported after ACL reconstruction, the technique to be chosen is not clear yet. Discussion/Conclusion: Quadriceps tendon autograft provides an excellent alternative as a graft choice in skeletally immature patients.
Lasmiditan and 5-Hydroxytryptamine in the rat trigeminal system; expression, release and interactions with 5-HT1 receptors
Authors: Edvinsson Jacob C. A. , Maddahi Aida , Christiansen Isabella M. , Reducha Philip V. , Warfvinge Karin , Sheykhzade Majid , Edvinsson Lars , Haanes Kristian A. 
Published: February 2022

Abstract
Background
5-Hydroxytryptamine (5-HT) receptors 1B, 1D and 1F have key roles in migraine pharmacotherapy. Selective agonists targeting these receptors, such as triptans and ditans, are effective in aborting acute migraine attacks and inhibit the in vivo release of calcitonin gene-related peptide (CGRP) in human and animal models. The study aimed to examine the localization, genetic expression and functional aspects of 5- HT1B/1D/1F receptors in the trigeminal system in order to further understand the molecular sites of action of triptans (5-HT1B/1D) and ditans (5-HT1F).

Methods
Utilizing immunohistochemistry, the localization of 5-HT and of 5-HT1B/1D/1F receptors was examined in rat trigeminal ganglion (TG) and combined with quantitative polymerase chain reaction to quantify the level of expression for 5-HT1B/1D/1F receptors in the TG. The functional role of these receptors was examined ex vivo with a capsaicin/potassium induced 5-HT and CGRP release.

Results
5-HT immunoreactivity (ir) was observed in a minority of CGRP negative C-fibres, most neuron somas and faintly in A-fibres and Schwann cell neurolemma. 5-HT1B/1D receptors were expressed in the TG, while the 5-HT1F receptor displayed a weak ir. The 5-HT1D receptor co-localized with receptor activity-modifying protein 1 (RAMP1) in Aδ-fibres in the TG, while 5-HT1B-ir was weakly expressed and 5-HT1F-ir was not detected in these fibres. None of the 5-HT1 receptors co-localized with CGRP-ir in C-fibres.
5-HT1D receptor mRNA was the most prominently expressed, followed by the 5-HT1B receptor and lastly the 5-HT1F receptor. The 5-HT1B and 5-HT1D receptor antagonist, GR127935, could reverse the inhibitory effect of Lasmiditan (a selective 5-HT1F receptor agonist) on CGRP release in the soma-rich TG but not in soma-poor TG or dura mater. 5-HT release in the soma-rich TG, and 5-HT content in the baseline samples, negatively correlated with CGRP levels, showing for the first time a physiological role for 5-HT induced inhibition.

Conclusion
This study reveals the presence of a subgroup of C-fibres that store 5-HT. The data shows high expression of 5-HT1B/1D receptors and suggests that the 5-HT1F receptor is a relatively unlikely target in the rat TG. Furthermore, Lasmiditan works as a partial agonist on 5-HT1B/1D receptors in clinically relevant dose regiments.
Exploring the effects of genetic variation on gene regulation in cancer in the context of 3D genome structure
Authors: Osman Noha , Shawky Abd-El-Monsif , Brylinski Michal 
Published: February 2022

AbstractBackgroundNumerous genome-wide association studies (GWAS) conducted to date revealed genetic variants associated with various diseases, including breast and prostate cancers. Despite the availability of these large-scale data, relatively few variants have been functionally characterized, mainly because the majority of single-nucleotide polymorphisms (SNPs) map to the non-coding regions of the human genome. The functional characterization of these non-coding variants and the identification of their target genes remain challenging.ResultsIn this communication, we explore the potential functional mechanisms of non-coding SNPs by integrating GWAS with the high-resolution chromosome conformation capture (Hi-C) data for breast and prostate cancers. We show that more genetic variants map to regulatory elements through the 3D genome structure than the 1D linear genome lacking physical chromatin interactions. Importantly, the association of enhancers, transcription factors, and their target genes with breast and prostate cancers tends to be higher when these regulatory elements are mapped to high-risk SNPs through spatial interactions compared to simply using a linear proximity. Finally, we demonstrate that topologically associating domains (TADs) carrying high-risk SNPs also contain gene regulatory elements whose association with cancer is generally higher than those belonging to control TADs containing no high-risk variants.ConclusionsOur results suggest that many SNPs may contribute to the cancer development by affecting the expression of certain tumor-related genes through long-range chromatin interactions with gene regulatory elements. Integrating large-scale genetic datasets with the 3D genome structure offers an attractive and unique approach to systematically investigate the functional mechanisms of genetic variants in disease risk and progression.
Loss of REST in breast cancer promotes tumor progression through estrogen sensitization, MMP24 and CEMIP overexpression
Authors: Cloud Ashley S. , Vargheese Aditya M. , Gunewardena Sumedha , Shimak Raeann M. , Ganeshkumar Sornakala , Kumaraswamy Easwari , Jensen Roy A. , Chennathukuzhi Vargheese M. 
Published: February 2022

AbstractBackgroundBreast cancer is the most common malignancy in women, and is both pathologically and genetically heterogeneous, making early detection and treatment difficult. A subset of breast cancers express normal levels ofREST(repressor element 1 silencing transcription factor) mRNA but lack functional REST protein. Loss of REST function is seen in ~ 20% of breast cancers and is associated with a more aggressive phenotype and poor prognosis. Despite the frequent loss of REST, little is known about the role of REST in the molecular pathogenesis of breast cancer.MethodsTCGA data was analyzed for the expression of REST target genes in breast cancer patient samples. We then utilized gene knockdown in MCF-7 cells in the presence or absence of steroid hormones estrogen and/ progesterone followed by RNA sequencing, as well as chromatin immunoprecipitation and PCR in an attempt to understand the tumor suppressor role of REST in breast cancer.ResultsWe show that REST directly regulatesCEMIP(cell migration-inducing and hyaluronan-binding protein, KIAA1199) andMMP24(matrix metallopeptidase 24), genes known to have roles in invasion and metastasis. REST knockdown in breast cancer cells leads to significant upregulation of CEMIP and MMP24. In addition, we found REST binds to RE-1 sites (repressor element-1) within the genes and influences their transcription. Furthermore, we found that the estrogen receptor (ESR1) signaling pathway is activated in the absence of REST, regardless of hormone treatment.ConclusionsWe demonstrate a critical role for the loss of REST in aggressive breast cancer pathogenesis and provide evidence for REST as an important diagnostic marker for personalized treatment plans.
The experience of loneliness among people with a “personality disorder” diagnosis or traits: a qualitative meta-synthesis
Authors: Ikhtabi Sarah , Pitman Alexandra , Toh Gigi , Birken Mary , Pearce Eiluned , Johnson Sonia 
Published: February 2022

Abstract
Background
Loneliness is prevalent among people with a “personality disorder” diagnosis or who have related personality traits, but the experience of loneliness among people with “personality disorder” diagnoses/traits has not been well described. A qualitative approach has potential to help understand the experience of loneliness among people with “personality disorder” diagnoses/traits, and to develop interventions that promote recovery. We therefore aimed to synthesise the qualitative literature relevant to this topic.

Method
We conducted a meta-synthesis of qualitative studies exploring the subjective experience of loneliness as reported by people with “personality disorder” diagnoses/traits. We searched four databases using pre-formulated search terms, selected eligible articles, appraised the quality of each, and analyzed data from eligible studies using thematic synthesis.

Result
We identified 39 articles that described the experience of loneliness in people with “personality disorder” diagnoses/traits. From extracted data, we identified seven themes: (1) disconnection and emptiness: a “haunting alienation”, (2) alienation arising from childhood experiences, (3) thwarted desire for closeness and connection, (4) paradox: for both closeness and distance, (5) experiences of existential loneliness, (6) recovery, embedded in a social world, and (7) group therapy: a setback. Our results suggest that for our sample early alienating and traumatic experiences may pave the way for experiences of loneliness, which further exacerbate “personality disorder” symptoms and distress.

Conclusion
Despite describing a need to belong and efforts to cope with unmet social needs, people with “personality disorder” diagnoses/traits (particularly “emotionally unstable personality disorder”) report experiencing an intense disconnection from other people. This seems rooted in early adversities, reinforced by later traumatic experiences. Given the apparent salience of loneliness to people with “personality disorder” diagnoses/traits, interventions focused on helping people connect with others, which may include both psychological and social components, have potential to be beneficial in reducing loneliness and promoting recovery.
A scattered landscape: assessment of the evidence base for 71 patient decision aids developed in a hospital setting
Authors: Danner Marion , Debrouwere Marie , Rummer Anne , Wehkamp Kai , Rüffer Jens Ulrich , Geiger Friedemann , Wolff Robert , Weik Karoline , Scheibler Fueloep 
Published: February 2022

Abstract
Background
Recent publications reveal shortcomings in evidence review and summarization methods for patient decision aids. In the large-scale “Share to Care (S2C)” Shared Decision Making (SDM) project at the University Hospital Kiel, Germany, one of 4 SDM interventions was to develop up to 80 decision aids for patients. Best available evidence on the treatments’ impact on patient-relevant outcomes was systematically appraised to feed this information into the decision aids. Aims of this paper were to (1) describe how PtDAs are developed and how S2C evidence reviews for each PtDA are conducted, (2) appraise the quality of the best available evidence identified and (3) identify challenges associated with identified evidence.

Methods
The quality of the identified evidence was assessed based on GRADE quality criteria and categorized into high-, moderate-, low-, very low-quality evidence. Evidence appraisal was conducted across all outcomes assessed in an evidence review and for specific groups of outcomes, namely mortality, morbidity, quality of life, and treatment harms. Challenges in evidence interpretation and summarization resulting from the characteristics of decision aids and the type and quality of evidence are identified and discussed.

Results
Evidence reviews assessed on average 25 systematic reviews/guidelines/studies and took about 3 months to be completed. Despite rigorous review processes, nearly 70% of outcome-specific information derived for decision aids was based on low-quality and mostly on non-directly comparative evidence. Evidence on quality of life and harms was often not provided or not in sufficient form/detail. Challenges in evidence interpretation for use in decision aids resulted from, e.g., a lack of directly comparative evidence or the existence of very heterogeneous evidence for the diverse treatments being compared.

Conclusions
Evidence reviews in this project were carefully conducted and summarized. However, the evidence identified for our decision aids was indeed a “scattered landscape” and often poor quality. Facing a high prevalence of low-quality, non-directly comparative evidence for treatment alternatives doesn’t mean it is not necessary to choose an evidence-based approach to inform patients. While there is an urgent need for high quality comparative trials, best available evidence nevertheless has to be appraised and transparently communicated to patients.
Enhanced bioenergy and nutrients recovery from wastewater using hybrid anodes in microbial nutrient recovery system
Authors: Shahid Kanwal , Ramasamy Deepika Lakshmi , Kaur Parminder , Sillanpää Mika , Pihlajamäki Arto 
Published: February 2022

Abstract
Background
The combined microbial fuel cell–microbial nutrient recovery system has lately been thoroughly explored from an engineering standpoint. The relevance of microbial communities in this process, on the other hand, has been widely underestimated.

Results
A lab-scale microbial nutrients recovery system was created in this work, and the microbial community structure was further defined, to give a thorough insight into the important microbial groups in the present system. We reported for the first-time different hybrid anodes of activated carbon and chitosan that were used in the microbial nutrient recovery system for bioenergy production, and, for the removal of COD and recovery of nutrients present in the wastewater. The hybrid anodic materials were studied to adapt electrochemically active bacteria for the recovery of nutrients and energy generation from wastewater without the need for an external source of electricity. The potential of the created hybrid anodes in terms of nutrients recovery, chemical oxygen demand elimination, and energy generation from municipal wastewater was thoroughly examined and compared with each other under similar operating conditions. When the COD loading was 718 mg/L, a total COD removal of ~ 79.2% was achieved with a hybrid activated carbon and chitosan anode having an equal ratio after 10 days of the operation cycle. The maximum power density estimated for hybrid anode (~ 870 mWm−2) was found.

Conclusion
Overall, this work reveals a schematic self-driven way for the collection and enrichment of nutrients (~ 72.9% phosphorus recovery and ~ 73% ammonium recovery) from municipal wastewater, as well as consistent voltage production throughout the operation.