bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of dementia or cognitive impairment in COPD patients: A meta-analysis of cohort studies
Authors: Wang Jun , Li Xuanlin , Lei Siyuan , Zhang Dong , Zhang Shujuan , Zhang Hailong , Li Jiansheng 
Published: September 2022

PurposeA meta-analysis of cohort studies was performed to evaluate the association between COPD and the risk of dementia or cognitive impairment.MethodsCohort studies that evaluated the association between COPD and the risk of dementia or cognitive impairment were identified by a systematic search of PubMed, Embase, Web of Science, and Cochrane Library databases. The search time frame was from database establishment to April 12, 2022, with two reviewers independently screening the literature and extracting data. The Newcastle-Ottawa Quality Assessment Scale (NOS) was used to conduct the quality evaluation. Then, a meta-analysis was performed using Stata 15.1 software.ResultsSix cohort studies including 428,030 participants were included. The overall quality of the included studies was high, with an average NOS score of over 7. Meta-analysis showed that compared to those without COPD at baseline, patients with COPD were associated with a significant increased risk of dementia (RR = 1.24, 95% CI = 1.03 ~ 1.50, I2 = 96.6%, z = 2.25, p = 0.024) and cognitive impairment (RR = 1.30, 95% CI = 1.13 ~ 1.49, I2 = 50.1%, z = 3.72, p &lt; 0.001). Subgroup analysis suggested no significant difference in the risk of dementia among COPD patients of different genders. Nevertheless, in terms of age, the risk of dementia varied among COPD patients of different ages, which was most distinguished in patients younger than 65 years.ConclusionCOPD patients have a higher risk of developing dementia or cognitive impairment compared to those without COPD, and this risk is not affected by gender but seems to be associated with age.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022325832.
White matter alterations in pediatric brainstem glioma: An national brain tumor registry of China study
Authors: Zhang Peng , Gu Guocan , Duan Yunyun , Zhuo Zhizheng , Pan Changcun , Zuo Pengcheng , Wang Yi , Li Xiaoou , Jiang Zhuang , Qu Liying , Liu Yaou , Zhang Liwei 
Published: September 2022

BackgroundPrevious studies have identified alterations in structural connectivity of patients with glioma. However, white matter (WM) integrity measured by diffusion kurtosis imaging (DKI) in pediatric patients with brainstem glioma (BSG) was lack of study. Here, the alterations in WM of patients with BSG were assessed through DKI analyses.Materials and methodsThis study involved 100 patients with BSG from the National Brain Tumor Registry of China (NBTRC) and 50 age- and sex-matched healthy controls from social recruitment. WM tracts were segmented and reconstructed using U-Net and probabilistic bundle-specific tracking. Next, automatic fiber quantitative (AFQ) analyses of WM tracts were performed using tractometry module embedded in TractSeg.ResultsWM quantitative analysis identified alterations in DKI-derived values in patients with BSG compared with healthy controls. WM abnormalities were detected in the projection fibers involved in the brainstem, including corticospinal tract (CST), superior cerebellar peduncle (SCP), middle cerebellar peduncle (MCP) and inferior cerebellar peduncle (ICP). Significant WM alterations were also identified in commissural fibers and association fibers, which were away from tumor location. Statistical analyses indicated the severity of WM abnormality was statistically correlated with the preoperative Karnofsky Performance Scale (KPS) and symptom duration of patients respectively.ConclusionThe results of this study indicated the widely distributed WM alterations in patients with BSG. DKI-derived quantitative assessment may provide additional information and insight into comprehensively understanding the neuropathological mechanisms of brainstem glioma.
Neutrophilia and post-radiation thrombocytopenia predict for poor prognosis in radiation-treated glioma patients
Authors: Hsu Eric J. , Thomas Jamie , Maher Elizabeth A. , Youssef Michael , Timmerman Robert D. , Wardak Zabi , Lee Minjae , Dan Tu D. , Patel Toral R. , Vo Dat T. 
Published: September 2022

IntroductionPoor outcomes in glioma patients indicate a need to determine prognostic indicators of survival to better guide patient specific treatment options. While preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) have been suggested as prognostic systemic inflammation markers, the impact of post-radiation changes in these cell types is unclear. We sought to identify which hematologic cell measurements before, during, or after radiation predicted for patient survival.MethodsA cohort of 182 patients with pathologically confirmed gliomas treated at our institution was retrospectively reviewed. Patient blood samples were collected within one month before, during, or within 3 months after radiation for quantification of hematologic cell counts, for which failure patterns were evaluated. Multivariable cox proportional hazards analysis for overall survival (OS) and progression-free survival (PFS) was performed to control for patient variables.ResultsMultivariable analysis identified pre-radiation NLR &gt; 4.0 (Hazard ratio = 1.847, p = 0.0039) and neutrophilia prior to (Hazard ratio = 1.706, p = 0.0185), during (Hazard ratio = 1.641, p = 0.0277), or after (Hazard ratio = 1.517, p = 0.0879) radiation as significant predictors of worse OS, with similar results for PFS. Post-radiation PLR &gt; 200 (Hazard ratio = 0.587, p = 0.0062) and a percent increase in platelets after radiation (Hazard ratio = 0.387, p = 0.0077) were also associated with improved OS. Patients receiving more than 15 fractions of radiation exhibited greater post-radiation decreases in neutrophil and platelet counts than those receiving fewer. Patients receiving dexamethasone during radiation exhibited greater increases in neutrophil counts than those not receiving steroids. Lymphopenia, changes in lymphocyte counts, monocytosis, MLR, and changes in monocyte counts did not impact patient survival.ConclusionNeutrophilia at any time interval surrounding radiotherapy, pre-radiation NLR, and post-radiation thrombocytopenia, but not lymphocytes or monocytes, are predictors of poor patient survival in glioma patients.
Normal ranges of non-invasive left ventricular myocardial work indices in healthy young people
Authors: Luo Xiuxia , Ge Quanrong , Su Jin , Zhou Ning , Li Ping , Xiao Xu , Chen Yan , Wang Dong , Ma Yujing , Ma Li , Zhu Yongsheng 
Published: September 2022

ObjectivesEchocardiographic global myocardial work (GMW) indices recently emerged to non-invasively evaluate left ventricular (LV) myocardial performance with less load-dependence than LV ejection fraction (LVEF) or global longitudinal strain (GLS). Yet, few data exist on the descriptions of LV GMW indices in young people. We therefore aimed to provide normal reference values of LV GMW in a healthy young cohort, and simultaneously to investigate factors associated with non-invasive GMW indices.Materials and methodsA total of 155 healthy young people (age 10–24 years, 59% male) underwent transthoracic echocardiography were recruited and further stratified for age groups and divided by gender. Two-dimensional speckle-tracking echocardiography (2D-STE) were performed to determine LV GLS, peak strain dispersion (PSD) and GMW indices, which include global work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE). LV peak systolic pressure was assumed to be equal to the systolic brachial artery cuff blood pressure.ResultsAge and gender specific normal ranges for LV GMW indices were presented. On multivariable analysis, GWI and GCW correlated more closely with systolic blood pressure (SBP) than LV GLS, while both GWW and GWE independently correlated with PSD (P &lt; 0.05 for all). There were no associations between any of the GMW indices with age, sex, body mass index, heart rate, left ventricular mass index as well as LV sizes or LVEF. Of noted, LV GMW indices had good intra-observer and inter-observer reproducibility.ConclusionWe reported echocardiographic reference ranges for non-invasive LV GMW indices in a large group of healthy young subjects, which are reproducible and reliable, and thus can be further used when assessing subclinical dysfunction in young people with myocardial diseases.
Advanced glycation endproducts mediate chronic kidney injury with characteristic patterns in different stages
Authors: Huang Xiaoxia , Li Bingyu , Hu Jiaqing , Liu Zhuanhua , Li Dongping , Chen Zhenfeng , Huang Hang , Chen Yanjia , Guo Xiaohua , Cui Yun , Huang Qiaobing 
Published: September 2022

Advanced glycation endproducts (AGEs) have been confirmed to play a causative role in the development of diabetic nephropathy (DN). In this study, we revealed that AGE-induced kidney injury with characteristic patterns in different stages and moesin phosphorylation plays a role in these processes. In WT mice treated with AGE-modified bovine serum albumin (AGE-BSA), distinct abnormal angiogenesis in Bowman’s capsule of the kidney emerged early after 1 m under AGE-BSA stimulation, while these neovessels became rare after 6 m. AGE-BSA also induced glomerular hypertrophy and mesangial expansion at 1 m but glomerular atrophy and fibrosis at 6 m. Electron microscopy imaging demonstrated the damage of foot process integrity in podocytes and the uneven thickening of the glomerular basement membrane in the AGE-BSA-treated group, which was more significant after 6 m of AGE-BSA treatment than 1 m. The kidney dysfunction appeared along with these AGE-induced morphological changes. However, these AGE-BSA-induced pathological changes were significantly attenuated in RAGE-knockout mice. Moreover, moesin phosphorylation was accompanied by AGE-BSA-induced alterations and moesin deficiency in mice attenuated by AGE-BSA-induced fibrosis. The investigation on glomerular endothelial cells (GECs) also confirmed that the phosphorylation of moesin T558 is critical in AGE-induced tube formation. Overall, this study suggests that AGEs mediate kidney injury with characteristic patterns by binding with RAGE and inducing moesin phosphorylation.
Global research trends in the subjective well-being of older adults from 2002 to 2021: A bibliometric analysis
Authors: Huang Derong , Wang Jian , Fang Huiling , Wang Xuehan , Zhang Yujie , Cao Shuo 
Published: September 2022

PurposeThis study aimed to explore current developments and trends in the field of subjective well-being (SWB) of older adults at a macro level and identify research hotspots.MethodsWe included reviews and articles on the SWB of older adults in the Web of Science Core Collection published from 2002 to 2021. We used CiteSpace to draw a knowledge map of the authors, institutions, countries, references, and keywords for visual analysis and used Microsoft Excel tables to count basic information details.ResultsA total of 354 papers were included, and the number of papers published over the past two decades showed a pattern of growth. The core force of publications was primarily attributed to studies conducted in Europe, North America, Asia, and Oceania, which have relatively major issues of aging and good economic strength. However, links between states, institutions, and authors were relatively weak. Cluster analysis showed that the research field could be divided into eight topics: the application of social psychology in the study of the SWB of older adults, aging in older adults, health condition of older adults, achieving successful aging, interventions for SWB, age differences in SWB research, an economic perspective of SWB research and social support for older adults. Current research frontiers are socioeconomic status, community, intervention, participation, adjustment, validation, and personality.ConclusionThe results of the present study provided a comprehensive picture in the research field of SWB of older adults. It showed that the mechanism, especially the bidirectional effect, between the SWB of older adults and its influencing factors is still worthy of further exploration. More research on evidence-based and intervention strategies should be conducted in the future.
Prevalence and correlates of suicidal ideation among older adults attending primary care clinics in Wuhan, China: A multicenter cross-sectional study
Authors: Zhu Xiao-Min , Xu Yan-Min , Wang Zong-Qin , Zhong Bao-Liang 
Published: September 2022

BackgroundPrimary care represents an ideal setting for screening for and managing suicidal older adults but the clinical epidemiology of suicidal ideation in Chinese older primary care patients remains unclear. This study investigated the prevalence and correlates of suicidal ideation in older Chinese adults receiving primary care.MethodsThis multicenter cross-sectional survey included a total of 769 older adults (≥65 years) from seven urban and six rural primary care clinics in Wuhan, China. The presence of depressive symptoms and suicidal ideation was assessed with the Geriatric Depression Scale and a single-item question “In the past 12 months, did you think about ending your life?,” respectively.ResultsThe 12-month prevalence of suicidal ideation in older primary care patients was 16.6%. Significant correlates of suicidal ideation were poor economic status (vs. good, OR = 2.80, P = 0.008), heart disease (OR = 2.48, P = 0.005), chronic gastric ulcer (OR = 3.55, P = 0.012), arthritis (OR = 2.10, P = 0.042), and depressive symptoms (OR = 11.29, P &lt; 0.001).ConclusionsSuicidal ideation is common among older adults attending Chinese primary care clinics. It is necessary to integrate psychological crisis intervention into primary care to prevent late-life suicide.
Prescribing behavior of antidepressants for depressive disorders: A systematic review
Authors: Lam Mary K. , Lam Lawrence T. , Butler-Henderson Kerryn , King Jonathan , Clark Tahnee , Slocombe Peta , Dimarco Katherine , Cockshaw Wendell 
Published: September 2022

ObjectiveGuidelines for the prescription of antidepressants for Depressive Disorders (DD) have been in place for a long time. However, there is a lack of systematic information on the prescribing behavior of antidepressants in evidence-based clinical practice in psychopharmacotherapy of depressive disorders. This may suggest a lack of implementation of clinical guidelines by clinicians. Existing literature mainly focuses on specific issues or medications. To provide general information on the prescribing behavior of antidepressants for depressive disorders, a systematic review of available studies since 2013 was conducted.Methods and materialsTo ensure a structured and systematic approach for the literature search and subsequent review process, the PRISMA guidelines for systematic reviews were followed. Major medical and health and psychological databases were used for the literature search. These included Ebsco Host, OVID, PubMed, Science Direct, Scopus, and Web of Science. The online application “Covidence” was employed to manage the titles collected and the full articles retrieved from the initial literature search. Upon finalizing the list of selected studies, data extraction was then conducted using a build-in function of the Covidence platform with the required information pre-set on a template for data extraction. The extracted information was tabulated and summarized in a table.ResultsForty-one studies were identified after an extensive search of the literature following the PRISMA guidelines. Of these, 37 quantitative studies providing useful information were systematically reviewed and information extracted. There was a high level of heterogeneity among these studies with different foci or characteristics. Most studies were conducted in or utilized data obtained from hospital and primary healthcare settings. SSRIs were the most commonly prescribed type of antidepressant in the past decade, particularly among younger patients. Among these studies, antidepressants were mainly prescribed by psychiatrists with some by other physicians and general practitioners. This might reflect differences in legislation regarding professional requirements for prescribers or clinical practices.ConclusionsA few themes that would be considered important in terms of the effect of prescription behavior on depression, specifically children/adolescents, special target populations, and off-label prescription. The results highlighted the need for more studies on a community-based approach and the role of GPs in the treatment of DD.
An online course about cosmetics improves skin care practices and skin health
Authors: Li Yu , Hua Wei , Tang Jie , Xiong Lidan , Li Li 
Published: September 2022

BackgroundThe incidence of cosmetics-associated dermatoses is on the rise recently while the awareness and knowledge about proper utilization of cosmetics are insufficient in both the public and specialists due to limited education about cosmetics.MethodsOur aim was to build and enhance the public's ability to select appropriate cosmetics, manage possible dermatoses and improve skin-care practices and skin health by offering access to medical information via free online courses. Consequently, we launched a massive open online course (MOOC), Appreciation and Analysis of Cosmetics. An online questionnaire was also sent to evaluate the effectiveness of the course.ResultsNearly 540,000 learners were enrolled in the course since 2014. In the discussion forum, there were 8,383 posts and 73,014 replies in total, where learners were mostly concerned about topics of sun protection, cleansing and proper utilization of cosmetics in some skin diseases. 645 learners answered the questionnaire with 88.84% of the them changed skin care practices and 50.39% reported improvement in skin health. Moreover, participants who completed the course reported better understanding and utilization of cosmetics-related knowledge (p values &lt; 0.05). 72.09% of respondents were willing to recommend this course to others.ConclusionsFree online public courses are feasible for conducting public health education campaigns related to cosmetics and associated dermatology to lower the incidence of cosmetics-associated dermatoses.
Different stages of chronic kidney disease are associated with physical performance in adults over 60 years
Authors: Song Peiyu , Xu Xinghong , Zhao Yinjiao , Gu Minghong , Chen Xiaoyu , Zhang Hui , Wu Xinze , Yu Chen , Niu Jianying , Ding Wei , Zhang Suhua , Guo Qi 
Published: September 2022

Objective:The purpose of this study was to determine the association between different stages of chronic kidney disease (CKD) and sarcopenia and its components in the Chinese older population.MethodsThe study comprised of 2,213 participants aged ≥ 60 years (1,025 men; mean age: 70.7 years) recruited from Shanghai who were invited to participate in a comprehensive geriatric assessment. Sarcopenia was defined according to the AWGS 2019 consensus update on sarcopenia diagnosis criteria. The glomerular filtration rate (GFR) was estimated using the equation that originated from the CKD-EPI equation, the stages of CKD are classified according to the Kidney Disease—Improving Global Outcomes (KDIGO).ResultsThe overall prevalence of sarcopenia was 19.0%, which increased with the severity of CKD. The prevalence of sarcopenia in patients with CKD 3–4 and kidney failure was significantly higher than that in normal and CKD 1–2 (p &lt; 0.05). In logistic regression analysis model, compared with normal and CKD 1 patients, kidney failure was significantly associated with the increased risk of sarcopenia and low grip strength (p &lt; 0.05); CKD 2, CKD 3–4 and kidney failure groups were significantly associated with an increased risk of low walking speed (p &lt; 0.05), respectively; while the association between CKD and muscle mass was not shown.ConclusionsIn our study, only decreased physical performance, as represented by walking speed, was significantly associated with increased CKD severity. This may improve the evidence for the prevention and intervention of sarcopenia in patients with CKD.
Multi-center, single-blind randomized controlled trial comparing functional electrical stimulation therapy to conventional therapy in incomplete tetraplegia
Authors: Anderson Kim D. , Korupolu Radha , Musselman Kristin E. , Pierce Jacqueline , Wilson James R. , Yozbatiran Nuray , Desai Naaz , Popovic Milos R. , Thabane Lehana 
Published: September 2022

BackgroundLoss of upper extremity function after tetraplegia results in significant disability. Emerging evidence from pilot studies suggests that functional electrical stimulation (FES) therapy may enhance recovery of upper extremity function after tetraplegia. The aim of this trial was to determine the effectiveness of FES therapy delivered by the Myndmove stimulator in people with tetraplegia.MethodsA multi-center, single-blind, parallel-group, two-arm, randomized controlled trial was conducted comparing FES to conventional therapy in adults (≥18 years) with C4–C7 traumatic incomplete tetraplegia between 4 and 96 months post-injury, and with a baseline spinal cord injury independence measure III -self-care (SCIM III-SC) score of ≤10. Participants were enrolled at four SCI-specialized neurorehabilitation centers in the U.S. and Canada. Participants were stratified by center and randomized in a 1:1 ratio to receive either 40 sessions of FES or conventional therapy targeting upper extremities over a 14-week period. Blinded assessors measured SCIM III, Toronto Rehabilitation Institute Hand Function Test, and Graded Redefined Assessment of Strength, Sensibility, and Prehension at baseline, after 20th session, after 40th session or 14 weeks after 1st session, and at 24 weeks after 1st session. The primary outcome measure was change in SCIM III-SC from baseline to end of the treatment. Based on the primary outcome measure, a sample size of 60 was calculated. Seventeen participants' progress in the study was interrupted due to the COVID-19 lockdown. The protocol was modified for these participants to allow them to complete the study.ResultsBetween June 2019 to August 2021, 51 participants were randomized to FES (n = 27) and conventional therapy (n = 24). Both groups gained a mean of 2 points in SCIM-SC scores at the end of treatment, which was a clinically meaningful change. However, there was no statistically significant difference between the groups on any outcomes.ConclusionForty sessions of FES therapy delivered by the MyndMove stimulator are as effective as conventional therapy in producing meaningful functional improvements that persist after therapy is completed. Limitations of this study include the impact of COVID-19 limiting the ability to recruit the target sample size and per-protocol execution of the study in one-third of the participants.RegistrationThis trial is registered at www.ClinicalTrials.gov, NCT03439319.