bluuebunny/crossref_metadata_2025_split huggingface dataset:
BNT162b2 vaccination enhances interferon-JAK-STAT-regulated antiviral programs in COVID-19 patients infected with the SARS-CoV-2 Beta variant
Authors: Knabl Ludwig , Lee Hye Kyung , Wieser Manuel , Mur Anna , Zabernigg August , Knabl Ludwig , Rauch Simon , Bock Matthias , Schumacher Jana , Kaiser Norbert , Furth Priscilla A. , Hennighausen Lothar 
Published: February 2022

Abstract
Background
SARS-CoV-2 infection activates interferon-controlled signaling pathways and elicits a wide spectrum of immune responses and clinical manifestations in human patients.

Methods
Here, we investigate the impact of prior vaccination on the innate immune response of hospitalized COVID-19 patients infected with the SARS-CoV-2 Beta variant through RNA sequencing of peripheral blood immune cells. Four patients had received the first dose of BNT162b2 about 11 days prior to the onset of COVID-19 symptoms and five patients were unvaccinated. Patients had received dexamethasone treatment. Immune transcriptomes were obtained at days 7-13, 20-32 and 42-60 after first symptomology.

Results
RNA-seq reveals an enhanced JAK-STAT-mediated immune transcriptome response at day 10 in vaccinated patients as compared to unvaccinated ones. This increase subsides by day 35. Expression of the gene encoding the antiviral protein oligoadenylate synthetase (OAS) 1, which is inversely correlated with disease severity, and other key antiviral proteins increases in the vaccinated group. We also investigate the immune transcriptome in naïve individuals receiving their first dose of BNT162b2 and identify a gene signature shared with the vaccinated COVID-19 patients.

Conclusions
Our study demonstrates that RNA-seq can be used to monitor molecular immune responses elicited by the BNT162b2 vaccine, both in naïve individuals and in COVID-19 patients, and it provides a biomarker-based approach to systems vaccinology.
Haloperoxidase-mimicking CeO2−xnanorods for the deactivation of human coronavirus OC43
Authors: Lang Jiayan , Ma Xiaojing , Chen Pengyu , Serota Max D. , Andre Nicole M. , Whittaker Gary R. , Yang Rong 
Published: February 2022

Schematic diagram of virucidal properties of haloperoxidase (HPO)-mimicking CeO2−x nanorods. CeO2−x nanorods catalysed the oxidative bromination of Br− and H2O2 to HOBr, which works as an antiseptic to kill viruses.
Coupling Hearing Health With Community-Based Group Therapy for Cognitive Health in Low-Income African American Elders
Authors: Postman Whitney Anne , Fischer Maureen , Dalton Kellie , Leisure Kailin , Thompson Samantha , Sankey Laura , Watkins Hailey 
Published: February 2022

Purpose:
To address disparities in the domains of hearing health and cognitive health experienced by African American elders in early stages of cognitive-communicative decline, a cognitive stimulation therapy (CST) group was established. The group intervention was coupled with comprehensive audiology services. This clinical focus article describes the features of the program, its implementation, and outcomes from its first cohort of participants.

Method:
CST is an evidence-based group intervention for elderly individuals living with mild-to-moderate dementia. The program was designed to (a) adapt and then apply CST to a target group of low-income African American elders and (b) integrate audiology services and education about hearing health and hearing loss in the context of CST therapy. In partnership with two community health centers in North St. Louis, a CST group was established for 12 elderly African American clients with cognitive-communicative impairments as measured by standardized assessments. During weekly group sessions, culturally informed activities and discussions were conducted with input from staff and participants to stimulate social interaction and cognition. Health topics relevant to age-related sensory and cognitive decline were introduced, with emphasis on management of common chronic diseases such as diabetes that are known to be associated with increased risk of hearing loss. Free hearing health services were provided, including screenings and, as needed, full audiological evaluations, cerumen management, otolaryngology referrals, hearing aids, and aural rehabilitation.

Results:
Participants' self-administered ratings and self-generated comments indicated meaningful increases in actionable knowledge about both hearing and cognitive health that led to enhanced utilization of available health services. They also suggested that audiology services were paramount to their enthusiastic adherence to the combined CST–audiology program.

Conclusion:
Interlinking of interventions for hearing and cognition reduced common barriers to care for this target group of low-income African American elders with cognitive-communicative impairments.
Benefits of Visual Language: How Acquisition of Signed Language Complements Spoken Language Development
Authors: Sanzo Kimberly 
Published: February 2022

Purpose:
This article provides evidence to refute an assumption often made regarding speech-language pathologists' (SLPs') role in developing language skills in children who are deaf. SLPs are experts in both speech and language development and disorders. When working with children who are deaf, their primary focus is often on developing speech and listening skills with the assumption that this will transfer to overall language development. The intent of this article is to provide evidence that language is dissociable from both speech and listening and that its development can be bolstered through exposure to robust linguistic input in both the oral and signed modalities. Encouraging the use of a signed language alongside a spoken language during the period of language acquisition can be highly beneficial for a child who is deaf for a multitude of reasons. Because these children may not fully access the ambient spoken language in their environment despite the consistent use of listening devices, providing an accessible signed language can help them attain language fluency in at least one language.

Conclusion:
The author suggests that SLPs should be educating parents of children who are deaf on the benefits of bimodal bilingualism and the complementary nature of simultaneous signed and spoken language acquisition.
The Impact of COVID-19 on Clinical Practice in Medically Based Settings: Speech-Language Pathologists' Perspectives
Authors: Stead Amanda , Vinson Monica , Michael Paul , Frank Dane 
Published: February 2022

Purpose:
Given the impact of COVID-19 on patients and the overall effects of COVID-era precautions on medical systems, the typical practice of speech-language pathologists (SLPs) has no doubt been impacted. The purpose of this study was to investigate practice patterns, experiences, and changes in referrals to medically based SLPs since the onset of COVID-19. The collective aim is to illuminate the unique perspectives and experiences of medically based SLPs during the COVID-19 era.

Method:
A national Qualtrics survey was conducted to capture the experiences and perspectives of SLPs in medical settings within the United States both before and since the onset of the pandemic. A total of 208 participants responded to the survey, and a mixed-methods design was implemented to examine responses regarding changes in patient populations, experiences with COVID-19 precautions, and overall impression of practice and patient impacts.

Results:
Results indicate SLPs in medical settings have seen a significant self-reported shift in referral patterns since the onset of COVID-19. Results of qualitative analyses revealed clinician perspectives regarding impacts to their settings in regard to COVID-19 precautions; patient flow; patient characteristics; and the mental health of staff, families, and patients.

Conclusions:
Overall, the impacts to SLPs' typical practice in medical systems appears to be pervasively negative and deeply interwoven from the clinician perspective. The relationships between changes in the medical systems as a whole during the pandemic era and patient population, acuity, and outcomes have created difficult practice conditions for practitioners in medical settings from the clinician vantage point.
Five Tips for Implementing Telepractice Interventions With Family Members of Young Children With Autism Spectrum Disorder
Authors: Douglas Sarah N. , Dunkel-Jackson Sarah M. , Bagawan Atikah , Sun Tiantian 
Published: February 2022

Purpose:
Telepractice has become a popular service delivery option for young children with autism spectrum disorder (ASD), especially as a result of the COVID-19 pandemic. However, practitioners can face some unique challenges when delivering interventions to young children and their families via telepractice. Furthermore, the use of telepractice requires specific practitioner skills, technologies, and family participation to ensure that interventions are effectively delivered. Drawing on the existing literature and our collective experience implementing telepractice-based interventions with families, we provide five practical tips for supporting families of children with ASD while implementing effective interventions via various telepractice modalities. Telepractice tips include the following: (a) think beyond video conferencing formats, (b) establish a meaningful and culturally responsive relationship with the family, (c) select appropriate interventions to support the child's development, (d) adhere to ethical and professional standards when implementing telepractice, and (e) gain knowledge and skills through professional development to enhance telepractice delivery.

Conclusion:
Using each of these tips will help practitioners support families with children with ASD in effective implementing telepractice interventions.
Embroidered Spoof Surface Plasmon Polariton Transmission Line for Wireless Body Sensor Network
Authors: Ghaddar Ali , Garnier Baptiste , Rault François , Lheurette Eric , Burgnies Ludovic 
Published: February 2022

AbstractA wearable Spoof Surface Plasmon Polariton Transmission Line (SSPP TL) operating at 2.45 GHz designed for embroidery production and on‐body communication is proposed. The SSPP TL supports both even and odd modes launched by near field coupling with a dipole antenna perpendicular and parallel to the TL, respectively. First, the experimental dispersion curves and transmission for the even and odd modes are favourably compared to simulations. Then, experimental transmission for each mode is compared with the Line‐Of‐Sight (LOS) transmission between two parallel‐oriented antennas. At 2.45 GHz, a transmission enhancement of 16 dB is measured for the even mode and it reaches up to 37 dB for the odd mode. A transmission enhancement of 30 dB is also measured at 2.45 GHz between two antennas with orthogonal orientations. Performances of the SSPP TL for Wireless Body Sensor Network are evaluated. Transmission is sustained for the SSPP TL under curvature and right angle bending. Transmission measured when both an arm and a copper plate obstacle between antennas were surrounded by the curved SSPP TL is compared with the obstructed LOS transmission. Measurements show a transmission enhancement up to 22 and 25 dB for the even and odd modes, respectively.
A novel stochastic thermo‐solar model for water demand supply using point estimate method
Authors: Askari Marzieh , Dehghani Moslem , Razmjoui Pouyan , GhasemiGarpachi Mina , Tahmasebi Dorna , Ghasemi Samira 
Published: February 2022

AbstractToday, many countries are facing water shortage due to population increase as well as groundwater pollution. To overcome this problem, a variety of techniques have been developed and implemented, one of the most recent being the condensation of water from humid air. Aqueous vapour in the Earth's atmosphere includes a significant amount of water that could be used to supply potable water. One of the methods for condensing water vapour in humid air is to use thermoelectric coolers. In this study, production of potable water by thermoelectric coolers, which is one of the optimal methods for trapping moisture in order to produce fresh water by condensation, has been studied. Fundamental concepts in the design of thermoelectric coolers for the production of potable water have been discussed by the thermoelectric element. According to the specification of temperature, pressure, relative humidity and desired geographical location variables, the maximum amount of water production can be achieved. Modelling results demonstrate higher water production with the thermoelectric method for Ramsar (318 L) in comparison to Bandar‐Abbas. Similarly, for this geographical point, the proposed hybrid solar panels efficiency results in 62.67% by mid‐December with 49.33% on thermal efficiency and 13.33% on electrical efficiency.
North Ecliptic Pole merging galaxy catalogue
Authors: Pearson W. J. , Suelves L. E. , Ho S. C.-C. , Oi N. , Brough S. , Holwerda B. W. , Hopkins A. M. , Huang T.-C. , Hwang H. S. , Kelvin L. S. , Kim S. J. , López-Sánchez Á. R. , Małek K. , Pearson C. , Poliszczuk A. , Pollo A. , Rodriguez-Gomez V. , Shim H. , Toba Y. , Wang L. 
Published: February 2022

Aims.We aim to generate a catalogue of merging galaxies within the 5.4 sq. deg. North Ecliptic Pole over the redshift range 0.0 <z <0.3. To do this, imaging data from the Hyper Suprime-Cam are used along with morphological parameters derived from these same data.Methods.The catalogue was generated using a hybrid approach. Two neural networks were trained to perform binary merger non-merger classifications: one for galaxies withz< 0.15 and another for 0.15 ≤z< 0.30. Each network used the image and morphological parameters of a galaxy as input. The galaxies that were identified as merger candidates by the network were then visually checked by experts. The resulting mergers will be used to calculate the merger fraction as a function of redshift and compared with literature results.Results.We found that 86.3% of galaxy mergers atz< 0.15 and 79.0% of mergers at 0.15 ≤z< 0.30 are expected to be correctly identified by the networks. Of the 34 264 galaxies classified by the neural networks, 10 195 were found to be merger candidates. Of these, 2109 were visually identified to be merging galaxies. We find that the merger fraction increases with redshift, consistent with literature results from observations and simulations, and that there is a mild star-formation rate enhancement in the merger population of a factor of 1.102 ± 0.084.
Evaluation eines mHealth unterstützten Heimübungsprogramms für Menschen mit Kniearthrose (mhexos) – Bedienbarkeit, Erfahrungen von Nutzer*innen und Outcome
Authors: Schäfer Axel , Löffler-Idel Ingrid , Adelt Elisabeth , Fielder Christina , Reinhardt Angelika , Wilhelm Nathalie , Lochwitz Andreas , Paelke Volker 
Published: February 2022

Zusammenfassung
Hintergrund Kniearthrose ist einer der Hauptgründe für Behinderungen und Mobilitätseinschränkungen bei älteren Menschen, die mit Leid und hohen Krankheitskosten verbunden sind. Nicht operative Therapien wie Übungstherapie, Maßnahmen zur Steigerung der körperlichen Aktivität und zur Unterstützung des Selbstmanagements können Schmerzen verringern sowie die Funktion und gesundheitsbezogene Lebensqualität verbessern. Entsprechende Heimübungsprogramme sind ein wichtiger Baustein der Therapie, die Adhärenz ist jedoch oft nicht ausreichend. Digitale Gesundheitsanwendungen sind, insbesondere unter den Bedingungen der aktuellen COVID-19-Pandemie, eine vielversprechende Möglichkeit, um Barrieren zu überwinden.
Ziel Untersuchung der Implementierbarkeit eines mHealth-Heimübungsprogramms für Patient*innen mit Kniearthrose (mhexos) in Hinblick auf Bedienbarkeit, Erfahrungen von Nutzer*innen, Nutzungsverhalten und der Veränderung gesundheitsbezogener Endpunkte.
Methode Patient*innen mit Kniearthrose führten das mHealth Heimübungsprogramm mhexos 4 Wochen lang durch. Die Umsetzung erfolgte über ein Tablet mit insgesamt 39 Übungsvideos zur Kräftigung, Balance und Koordination, die in 3 Schwierigkeitsstufen konfiguriert werden können. Über eine App wurden Daten zur Schmerzintensität und der selbst wahrgenommenen Belastung erfasst. Es wurden leitfadengestützte Interviews durchgeführt und Fragebögen zur Erfassung der Bedienbarkeit und der Erfahrungen der Nutzer*innen sowie zu gesundheitsbezogenen Endpunkten an 2 Messzeitpunkten eingesetzt.
Ergebnisse Es wurden 10 Patient*innen und 7 Therapeut*innen eingeschlossen. Das mHealth-Heimübungsprogramm konnte in die Praxis und den Alltag der Teilnehmenden implementiert werden. Die App wurde überwiegend als bedienungsfreundlich und motivierend eingeschätzt, die Therapietreue war mit einer Übungsfrequenz von 2,7 × pro Woche (SD 0,6) hoch. In den gesundheitsbezogenen Endpunkten zeigten sich im Interventionszeitraum kleine, klinisch und statistisch nicht signifikante Veränderungen.
Schlussfolgerung: mhexos scheint geeignet, Heimübungsprogramme für Menschen mit Kniearthrose unter den Rahmenbedingungen der Routineversorgung zu unterstützen. Für eine weitergehende Beurteilung der klinischen Wirksamkeit sind kontrollierte Studien nötig.
Das Alpha-Gal-Syndrom
Authors: Mülleneisen Norbert K. , Bergenroth Tanja , Salge Stephanie 
Published: February 2022

ZusammenfassungDie Einschränkung der Lebensqualität bei Urtikaria ist stark abhängig vom subjektiven Empfinden und der Lokalisation der Quaddeln. Leitlinien sollten deshalb die Einteilung nach Einschränkung der Lebensqualität in Diagnostik und Therapie stärker berücksichtigen als die starre Einteilung nach akut und chronisch an Hand der Sechs-Wochen-Grenze.
Medikamentöse Behandlung des benignen Prostatasyndroms: Was gibt’s Neues?
Authors: Michel Martin C. , Madersbacher Stephan 
Published: February 2022

ZusammenfassungAuch Jahrzehnte nach der Einführung der 5α-Reduktasehemmer und der α1-Adrenozeptor-Antagonisten ergeben sich praxisrelevante, neue Daten zu deren erwünschten und unerwünschten Wirkungen. Einige der neuen Befunde sind ihrer Natur nach ernst zu nehmen, aber bisher unzureichend abgesichert wie z.B. ein Zusammenhang mit Depressionen oder Demenz. Verschiedene Kombinationsbehandlungen wurden getestet. Dabei war die Kombination der Monotherapie häufig statistisch signifikant überlegen, aber der Unterschied bewegte sich meistens in der Größenordnung von 1 IPSS-Punkt, was Zweifel an der klinischen Relevanz der Beobachtungen im Gruppenmittel lässt. Die neuen Daten ermöglichen eine weiter individualisierte BPS-Behandlung, machen die individuelle Nutzen-Risiko-Abwägung aber komplizierter.
Early Neurologic Complications and Long-term Neurologic Outcomes of
Extracorporeal Membrane Oxygenation Performed in Children
Authors: Azapagasi Ebru , Kendirli Tanıl , Tunçer Gokcen Oz , Perk Oktay , Isikhan Selen Yilmaz , Tıras Serap Teber , Eyileten Zeynep , Ince Erdal , Uysalel Adnan , Akar Ahmet Rüçhan 
Published: February 2022

Abstract
Background We aimed at evaluating acute neurologic complications (ANC) and
clinical outcome at a 2-year follow-up in children after extracorporeal membrane
oxygenation (ECMO).
Methods We conducted a single-center, retrospective review of our patient
cohort aged between 1 month and 18 years at the time of ECMO support (between
June 2014 to January 2017). Outcome analysis included ANC and their clinical
consequences.The Pediatric Overall Performance Category (POPC) and Pediatric
Cerebral Performance Category (PCPC) were used for neurologic assessment
performed at discharge from the hospital and at 2nd year follow-up.
Results There were 35 children who required ECMO. The median ECMO time was
9 days (range 2–32 days). Decannulation from ECMO was achieved in
68.6% of patients, and overall, 42.8% survived (15 patients),
The incidence of ANC in the surviving patients was 40% (6 children). ANC
were intracranial hemorrhage, seizures, cerebral infarction, which occurred in
one, two and three of the 15 surviving patients respectively (6.6, 13.3 and
20%). A higher rate of organ failure was related to death
(p=0.043), whereas duration on ECMO was a risk factor for the
development of ANC (p<0.05). At hospital discharge, the 14 patients
evaluated had normal development or -mild disability in 73.2%, and at
the 2-year follow-up, 93.4% had these scores.
Conclusion Children who receive ECMO have a risk to develop ANC, which was
related to the length of ECMO treatment, while survival was related to less
organ failure, Long-term neurological outcome was good in our patient
cohort.
Stereoselective Synthesis of Dispirooxindoles Incorporating Pyrrolo[2,1-a]isoquinoline via [3+2] Cycloaddition of Azomethine Ylides with a Thiazolo[3,2-a]indole Dipolarophile
Authors: Deepthi Ani , Thomas Noble V. , Meenakshy C. B. , Leena Sruthi S. 
Published: February 2022

AbstractHighly regio- and stereoselective synthesis of dispiropyrrolo[2,1-a]isoquinoline-oxindoles have been developed by the one-pot three component reaction of isatins, 1,2,3,4-tetrahydroisoquinoline (THIQ), and a thiazolo[3,2-a]indole derivative. The reaction proceeds regioselectively through an exo-Re face approach of the in situ generated tetrahydroisoquinolium ylides towards the dipolarophile yielding the corresponding [3+2] cycloadducts in excellent yields and stereoselectivity.
Prognosis of 22- and 23-Gestational-Week-Old Infants at Our Facility: A Retrospective Cohort Study
Authors: Yanagisawa Toshimitsu , Nakamura Tomohiko , Kokubo Masayo 
Published: February 2022

Objective This study aimed to compare inborn infants aged 22 and 23 gestational weeks at our hospital to assess for differences in survival and long-term prognosis.
Study Design We retrospectively analyzed 22- and 23-gestational-weeks-old infants born in our hospital between January 2011 and December 2018. The prognosis of inborn infants in Japan was also calculated using the Neonatal Research Network of Japan (NRNJ) data during the same period.
Results The survival rates at our institution's neonatal intensive care unit discharge, including stillbirth, were 72 and 89% at 22 and 23 gestational weeks, respectively. The mortality rate and neurodevelopmental impairment (NDI) rate at 3 years of age, including stillbirth, were 58 and 32% at 22 and 23 weeks, respectively. Cerebral palsy, mental developmental retardation, visual impairment, and hearing impairment defined NDI. The prognosis at our hospital was better than the average calculated using NRNJ data. Survival rates varied among facilities, and some facilities had survival rates similar to that of our hospital.
Conclusion The prognosis of 22-gestational-week-old inborn infants was inferior to that of 23 gestational weeks in our institution but was better than previously reported. If aggressive treatment is provided, survival without sequelae can be fully expected even for 22-gestational-week-old infants.
Key Points