bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parent and child self‐ and co‐regulation during pediatric venipuncture: Exploring heart rate variability and the effects of a mindfulness intervention
Authors: Constantin Kaytlin L. , Moline Rachel L. , Pillai Riddell Rebecca , Spence Jeffrey R. , Fiacconi Chris M. , Lupo‐Flewelling Kathryn , McMurtry C. Meghan 
Published: May 2022

AbstractNeedle procedures are common throughout childhood and often elicit distress in children and parents. Heart rate variability (HRV), as an index of emotion regulation, can inform both self‐regulatory and co‐regulatory processes. Mindfulness may serve to regulate distress; however, no research has studied mindfulness or parent and child regulatory responding concurrently during venipuncture. Stemming from a randomized controlled trial investigating a mindfulness intervention, this study sought to describe regulatory responding (via HRV) throughout pediatric venipuncture and the role of cognitive–affective factors (mindfulness, parent anxiety, catastrophizing) in 61 parent–child dyads (7–12 years). We examined (1) patterns of parent and child HRV throughout venipuncture and whether a brief, randomly assigned audio‐guided mindfulness versus control exercise affected this pattern and (2) the extent to which changes in parent and child HRV were synchronized throughout venipuncture, and whether parent catastrophizing and anxiety moderated this association. HRV differed as a function of procedural phase. Practicing the mindfulness versus control exercise did not consistently affect HRV in dyads. Positive synchrony was observed during the end of the intervention in dyads with high parental catastrophizing. Otherwise, a pattern of nonsynchrony emerged. Results provide foundational knowledge regarding children's internal (self) and external (parent) regulation mechanisms. RCT registration: NCT03941717.
Integrating microclimatic variation in phenological responses to climate change: A 28‐year study in a hibernating mammal
Authors: Tamian Anouch , Viblanc Vincent A. , Dobson F. Stephen , Neuhaus Peter , Hammer Tracey L. , Nesterova Anna P. , Raveh Shirley , Skibiel Amy L. , Broussard David , Manno Theodore G. , Rajamani Nandini , Saraux Claire 
Published: May 2022

AbstractPhenological shifts associated with directional changes in climate, resulting in earlier spring activities, have been documented in several animal species. However, the extent to which species respond to overall climate change versus local climate variation is rarely studied. In addition, climate data are usually averaged over large spatial scales, even though local heterogeneity in habitats may be high, and species might be more susceptible to changes in local rather than global climate conditions. In this study, we examined the effects of spatiotemporal climate variation and climate change on the phenology of a hibernating mountain rodent, the Columbian ground squirrel (Urocitellus columbianus). Over 28 years of research (1992–2019), we studied the relationship between the microclimatic conditions experienced by adult and juvenile ground squirrels from four neighboring meadows, and their dates of emergence from hibernation. We used a microclimate model to calculate microclimate variables (local snow depth, soil temperature, air temperature, wind speed, and humidity) at an hourly scale, a 5‐m spatial resolution, and at animal height on the study sites over 28 years. Emergence dates varied with age and sex, among years, as well as among and within meadows, with some areas averaging up to 10 days earlier emergence dates from hibernation than others. While emergence dates tended to be delayed throughout the study period, long‐term temporal changes and interannual variability in emergence dates differed among meadows and depended on individual age and sex. Dates of hibernation emergence were correlated with local climate variables considered either during hibernation or during the preceding summer. Ground squirrels emerged earlier in years or at locations when/where snow melted earlier (years: all individuals excluding 2‐year‐old males, locations: yearlings and older females), and when the previous summer was less windy (≥3‐year‐old individuals) and more humid (2‐year‐old males). Two‐year‐old male ground squirrels also emerged later in locations where snow depth during winter was higher. Using a microclimate model allowed realistic predictions of phenological responses to climate, highlighting its potential for research on animal responses to abiotic change.
Home‐based cardiac rehabilitation using information and communication technology for heart failure patients with frailty
Authors: Nagatomi Yuta , Ide Tomomi , Higuchi Tae , Nezu Tomoyuki , Fujino Takeo , Tohyama Takeshi , Nagata Takuya , Higo Taiki , Hashimoto Toru , Matsushima Shouji , Shinohara Keisuke , Yokoyama Tomiko , Eguchi Aika , Ogusu Ayumi , Ikeda Masataka , Ishikawa Yusuke , Yamashita Fumika , Kinugawa Shintaro , Tsutsui Hiroyuki 
Published: May 2022

AbstractAimsCardiac rehabilitation (CR) is an evidence‐based, secondary preventive strategy that improves mortality and morbidity rates in patients with heart failure (HF). However, the implementation and continuation of CR remains unsatisfactory, particularly for outpatients with physical frailty. This study investigated the efficacy and safety of a comprehensive home‐based cardiac rehabilitation (HBCR) programme that combines patient education, exercise guidance, and nutritional guidance using information and communication technology (ICT).Methods and resultsThis study was a single‐centre, open‐label, randomized, controlled trial. Between April 2020 and November 2020, 30 outpatients with chronic HF (New York Heart Association II–III) and physical frailty were enrolled. The control group (n = 15) continued with standard care, while the HBCR group (n = 15) also received comprehensive, individualized CR, including ICT‐based exercise and nutrition guidance using ICT via a Fitbit® device for 3 months. The CR team communicated with each patient in HBCR group once a week via the application messaging tool and planned the training frequency and intensity of training individually for the next week according to each patient's symptoms and recorded pulse data during exercise. Dietitians conducted a nutritional assessment and then provided individual nutritional advice using the picture‐posting function of the application. The primary outcome was the change in the 6 min walking distance (6MWD). The participants' mean age was 63.7 ± 10.1 years, 53% were male, and 87% had non‐ischaemic heart disease. The observed change in the 6MWD was significantly greater in the HBCR group (52.1 ± 43.9 m vs. −4.3 ± 38.8 m; P < 0.001) at a 73% of adherence rate. There was no significant change in adverse events in either group.ConclusionsOur comprehensive HBCR programme using ICT for HF patients with physical frailty improved exercise tolerance and improved lower extremity muscle strength in our sample, suggesting management with individualized ICT‐based programmes as a safe and effective approach. Considering the increasing number of HF patients with frailty worldwide, our approach provides an efficient method to keep patients engaged in physical activity in their daily life.
Nanomolar Level Fluorogenic Detection of Cyanide with an Amide Functionalized Zirconium Metal‐Organic Framework and Its Application in Real‐World Cyanide Monitoring
Authors: Ghosh Subhrajyoti , Nagarjun Nagarathinam , Alam Masud , Dhakshinamoorthy Amarajothi , Biswas Shyam 
Published: May 2022

AbstractThis work contains synthesis of a di‐amide linker based Zr(IV) metal‐organic framework (MOF, 1) and its characterization with by PXRD, elemental analysis, FE‐SEM, EDX and FT‐IR analysis and application for the detection of toxic cyanide in aqueous medium. Furthermore, the physicochemical stability of the sensor was judged by the thermogravimetric analysis (TGA) and PXRD analysis. TGA curve of 1 displayed that the thermal stability of the probe was up to 230 °C. The MOF material was stable in sensing medium and in wide pH range (pH=2–8) which were confirmed by PXRD analysis of the recovered samples. The surface area (BET) of this porous sensor was 672 m2/g with a pore volume of 0.36 cm3/g at p/po=0.5. Guest free form of the MOF material (1’) displayed its high efficiency for the fluorescence recognition of cyanide (CN−) with an extraordinary limit of detection of 76.4 nM in aqueous medium. Comparable recognition time (10 min) as the other available chemosensors of CN− ion and sensing of CN− using easily portable paper strips make this probe an extraordinary chemosensor for CN− ions. Together with paper strip based sensing, detection of CN− in apple seeds, various real water samples and wide ranges of pH solutions are the special features of the probe. The abstraction of amide proton by CN− ion favors “turn‐on” sensing, which was revealed by 1H‐NMR titration. This sensor of cyanide can also be used as luminescent switch due to its reversible nature of sensing.
Role of Maillard Reaction Products as Antioxidants in Washed Cod and Washed Turkey Muscle Oxidized by Added Hemoglobin
Authors: Liu Ling , Yin Jie , Richards Mark P. 
Published: May 2022

AbstractThe ability of Maillard reaction products (MRPs) to inhibit hemoglobin (Hb)‐mediated lipid oxidation is examined in washed cod muscle (WCM) and washed turkey breast muscle (WTM). Lipid peroxides and thiobarbituric acid reactive substances (TBARS) are used as markers of primary and secondary lipid oxidation products, respectively. MRPs inhibits Hb‐mediated lipid oxidation in WCM (p < 0.01) but are weakly inhibitory in WTM. α‐tocopherol concentration is 24‐fold greater in WCM compared to WTM. The elevated α‐tocopherol content of WCM may partly explain the enhanced antioxidant effectiveness of MRPs in WCM, noting that MRPs and α‐tocopherol act synergistically in the scavenging of free radicals. MRPs are more effective in inhibiting lipid oxidation in WCM at pH 6.6 compared to lower pH values. Antioxidant effectiveness of MRPs diminishes when stored refrigerated but not with frozen storage. MRPs obtained by 3 h heating contains more Maillard reaction intermediates than 2 h heating, which better inhibits LOOH formation (p < 0.01). These intermediates decrease faster during refrigerated compared to frozen storage. These studies suggest elevated pH and sufficient endogenous tocopherols are required for low concentrations of MRPs to protect highly unsaturated lipid in washed muscle from oxidation by hemoglobin.Practical Applications: This study shows that the maillard reaction products (MRPs) can be used to inhibit the oxidation of tocopherol‐rich meat products, and the MRPs stored in the frozen condition for a certain period also have antioxidant activity.
Total Synthesis of (−)‐Cannabidiol‐C4
Authors: Marzullo Paola , Maiocchi Alice , Paladino Giuseppe , Ciriello Umberto , Lo Presti Leonardo , Passarella Daniele 
Published: May 2022

AbstractCannabidiol‐C4 1 (CBD‐C4, cannabidibutol) is a natural product that is present in the extracts of Cannabis. Its isolation has not been reported to date. The aim of the proposed synthesis is to secure the availability of the pure compound, its spectroscopic characterization, and to confirm its presence in low amounts in the extracts. The enantioselective total synthesis is based on a) the use 3,5‐dimetoxybenzaldehyde as starting material, b) Corey‐Bakshi‐Shibata reduction, c) Claisen‐Ireland rearrangement, d) ring‐closing metathesis, and e) completely not‐trivial demethylation induced by sodium ethanethiolate.
Practical Insights into the Impedance Response of Interdigitated Electrodes: Extraction of Relative Static Permittivity and Electrolytic Conductivity
Authors: Sapotta Benedikt , Schwotzer Matthias , Franzreb Matthias 
Published: May 2022

AbstractThis work aims to provide a detailed understanding of the challenges related to the computation of the relative static permittivity and electrolytic conductivity of a sample medium from its impedance response recorded with interdigitated electrode (IDE) geometries. Within the scope of the study, impedance data has been measured and evaluated for a total of nine sample media using two distinct IDE geometries. Particular emphasis is laid upon the compensation of parasitic influences affecting the impedance response. With the raw data supporting this study fully disclosed, the reader is offered the opportunity to comprehensively retrace the evaluation procedure proposed in the text.
Spatial variations of crustal thickness and Poisson's ratio in the northeastern region of India based on receiver function analysis
Authors: Shukla Neeharika , Hazarika Devajit , Kundu Abhishek , Mukhopadhyay Sagarika 
Published: May 2022

Crustal configuration beneath the northeastern region of India has been investigated with the help of receiver function (RF) analysis of teleseismic earthquakes recorded by 19 broadband seismological stations. We adopted the H‐k stacking method to estimate crustal thickness and Poisson's ratio beneath each recording station. The study reveals a large variation in crustal thickness and Poisson's ratio which are correlated with the complex geology and tectonics of the region. The crust is observed to be thinner (36.5–41.6 km) beneath Bengal Basin, Shillong Plateau, and the Brahmaputra valley compared to the Indo‐Burma Ranges (IBR) (~40–54 km) and Arunachal Higher Himalaya (TAWA station, ~45 km) and Sikkim Himalaya (GTK station, ~46.5 km). A large variation of Poisson's ratio is observed in the region (~0.230–0.306). Poisson's ratio is generally low‐to‐intermediate in the Shillong‐Mikir Plateau, Bengal Basin, and the Brahmaputra Valley, while it is intermediate‐to‐high in the Tripura Fold Belt and the northern part of the IBR. The high Poisson's ratio in the Tripura Fold Belt is due to the presence of basaltic basement rock and clay minerals existing in the sedimentary rocks, whereas the presence of partially serpentinized rock in the ophiolitic mélange complex causes a high Poisson's ratio in the IBR.
The challenges of improving infant research methods
Authors: Kominsky Jonathan F. 
Published: May 2022

AbstractAll analysis‐based suggestions for improving infant research are limited by the quality and quantity of data that infant research methods can produce. In this commentary, I expand on Byers‐Heinlein et al. (2022)'s call for methodological innovation by discussing in more detail how we as a field can improve and encourage the improvement of our methods.
The role of perceived discrimination in linking religious practices and well‐being: A study among Muslim Afghan refugees in the Netherlands
Authors: Bender Michael , van Osch Yvette , He Jia , Güngör Derya , Eldja Azim 
Published: May 2022

Minorities facing adverse intergroup contact can experience both increased identification with their ethnic group and decreased identification with a host majority group. First, we argue it is important to understand what is associated with adversity, particularly in previously overlooked samples. Muslim refugee samples are often treated differently and experience more adversity than other immigrants. Second, we combine insights on the role of religiosity in acculturation with the observation that religiosity may not have positive effects in societies that do not value (a specific) religion (religiosity‐as‐social‐value hypothesis) as well as insights from rejection (dis)identification models, to understand which domains of being a Muslim are associated with discrimination, (dis‐)identification and well‐being. We hypothesized that Muslim religious practices, but not beliefs, coping or values, are associated with increased perceived discrimination, and suggest that this is because practices are highly visible. Data from Muslim Afghan refugees in the Netherlands (N = 183) revealed that indeed only religious practices were related positively to perceived discrimination. Perceived discrimination in turn mediated the relationship between religious practices and dis‐identification with the majority group, as well as the relationship between religious practices and well‐being. We suggest that the visibility of one's religious behaviour is relevant for acculturation outcomes.
Pathological complete response of plasmacytoid variant bladder cancer to pembrolizumab following genomic analysis
Authors: Goto Yusuke , Tanaka Satoki , Maruo Masafumi , Sugawara Sho , Chiba Kazuto , Miyazaki Kanetaka , Inoue Atsushi , Ichikawa Tomohiko , Nagata Maki 
Published: May 2022

IntroductionPlasmacytoid variant bladder cancer is a rare variant of urothelial carcinoma that accounts for 1% of bladder cancers. Plasmacytoid variant urothelial carcinoma is characterized by an aggressive phenotype and poor clinical outcomes.Case presentationA 61‐year‐old woman presented with gross hematuria. Cystoscopy showed a 16‐mm solid tumor. Transurethral resection of the bladder tumor was performed, and the pathological diagnosis was invasive plasmacytoid variant urothelial carcinoma. Although the pathological T stage was pT1, computed tomography showed right obturator lymph node swelling. Since previous reports indicate poor response to chemotherapy for this disease, clinical sequencing was performed. Based on the high tumor mutation burden revealed, pembrolizumab was administered for 4 cycles, and computed tomography showed a partial response. Robot‐assisted radical cystectomy was performed, and a pathological complete response including the pelvic lymph node was observed.ConclusionPembrolizumab may be a treatment option for plasmacytoid variant urothelial carcinoma following genomic analysis.
Thermally drawn multifunctional fibers: Toward the next generation of information technology
Authors: Shen Yanan , Wang Zhe , Wang Zhixun , Wang Jiajia , Yang Xiao , Zheng Xinghua , Chen Haisheng , Li Kaiwei , Wei Lei , Zhang Ting 
Published: May 2022

AbstractAs the fundamental building block of optical fiber communication technology, thermally drawn optical fibers have fueled the development and prosperity of modern information society. However, the conventional step‐index configured silica optical fibers have scarcely altered since their invention. In recent years, thermally drawn multifunctional fibers have emerged as a new yet promising route to enable unprecedented development in information technology. By adopting the well‐developed preform‐to‐fiber manufacturing technique, a broad range of functional materials can be seamlessly integrated into a single fiber on a kilometer length scale to deliver sophisticated functions. Functions such as photodetection, imaging, acoustoelectric detection, chemical sensing, tactile sensing, biological probing, energy harvesting and storage, data storage, program operation, and information processing on fiber devices. In addition to the original light‐guiding function, these flexible fibers can be woven into fabrics to achieve large‐scale personal health monitoring and interpersonal communication. Thermally drawn multifunctional fibers have opened up a new stage for the next generation of information technology. This review article summarizes an overview of the basic concepts, fabrication processes, and developments of multifunctional fibers. It also highlights the significant progress and future development in information applications.image
Differences in food insecurity across the rural/urban spectrum—The role of trade flows
Authors: Beverly Mariah , Neill Clinton L. 
Published: May 2022

AbstractThere has been little work relating food flows with food insecurity, and how inter‐county trading can drive differences across the rural/urban divide. Using rural–urban continuum codes in combination with a new data set on food flows at the county level we examine the correlation between food insecurity and trade. Results indicate heterogeneous impacts of food trade flows and county types on food insecurity rates. From Oaxaca‐Blinder decompositions we find that differences between rural and metropolitan counties are largely due to explained factors, but differences between nonmetropolitan, nonrural counties and the other county types are unexplained factors.
Hsa_circ_0000285 contributes to gastric cancer progression by upregulating FN1 through the inhibition of miR‐1278
Authors: Wang Xue , Tan Mao , Huang He , Zou Yanlei , Wang Mengqiao 
Published: May 2022

AbstractBackgroundGastric cancer (GC) is one of the most severe cancers worldwide, particularly in China. Circular RNA (circRNA) plays an essential role in GC. Hsa_circ_0000285 regulates the progression of several cancers. However, its role in GC has not been reported. This study elucidated the molecular mechanism and role of hsa_circ_0000285 in GC progression.MethodsGC cells were transfected with silencers of hsa_circ_0000285 and fibronectin 1 (FN1), an inhibitor of miR‐1278, and their negative controls (NC). Mice were injected with short hairpin (sh) RNAs targeting hsa_circ_0000285 or NC. The expression levels of hsa_circ_0000285, miR‐1278, and FN1 were assessed using western blotting and reverse transcription quantitative real‐time polymerase chain reaction (qRT‐PCR). Several assays were used to evaluate cell proliferation, invasion, and apoptosis. Tumor burden was also analyzed. The interactions between miR‐1278, hsa_circ_0000285, and FN1 were ascertained using dual‐luciferase reporter assays. An RNA immunoprecipitation (RIP) assay was used to assess the enrichment of hsa_circ_0000285 and miR‐1278 in GC.ResultsHsa_circ_0000285 was significantly overexpressed in the GC tissues. Silencing hsa_circ_0000285 inhibited cell proliferation and invasion, promoted apoptosis, and inhibited tumor development. Hsa_circ_0000285 sponged miR‐1278. Inhibition of miR‐1278 in vitro reversed the effects of hsa_circ_0000285 silencing on GC progression. MiR‐1278 targeted FN1, and silencing FN1 neutralized the effects of miR‐1278 inhibitors on GC progression.ConclusionsThe hsa_circ_0000285/miR‐1278/FN1 axis regulated GC progression. In addition, it may serve as a potential therapeutic biomarker for GC.
‘My new home?’: Strategies and challenges of refugee integration programs in Portugal
Authors: Constantino Catarina , Minas Maria 
Published: May 2022

AbstractEurope is experiencing the greatest humanitarian crisis since the Second World War, which is reflected in an unprecedented influx of refugees into Europe. Against this backdrop, the effective strategies and challenges faced by the programs designed to facilitate the integration of refugees need to be understood. Portugal, together with other countries, has opened its doors to refugees. In this study, qualitative methods are used to understand how the refugee reception and integration are being conducted in Portugal. The perspectives of both refugees and professionals involved in programs aimed at promoting the integration of refugees are taken into consideration. The results suggest that, despite the existence of best practices in the various types of programs, there is significant room for improvement. Thus, specific changes to these programs are proposed with a view to boosting their efficacy and facilitating the integration of refugees in Portugal.