bluuebunny/crossref_metadata_2025_split huggingface dataset:
Significance of platelet parameters in squamous cell carcinoma of oral cavity – A case-control study
Authors: Anand Ankit , Raju Kalyani , Azeem Mohiyuddin S. M. 
Published: June 2022

Introduction:
Tumor microenvironment plays an important role in cancer progression. Platelets are one of the components of the tumor environment shown to have a role in cancer survival and progression.

Materials and Methods:
Ninety-six cases of squamous cell carcinoma (SCC) cases of the oral cavity and 96 age/sex-matched healthy controls were considered for the study. Data regarding platelet count, platelet distribution width (PDW), mean platelet volume (MPV), Platelet-Large Cell Ratio (P-LCR), Plateletcrit (PCT), platelet/neutrophil ratio (PNR), platelet/lymphocyte ratio (PLR), and Platelet/Monocyte Ratio (PNR) from automated hematology analyzer records and clinicopathological data from the Department of Pathology were captured. These data were compared between cases and controls and also with tumor size, tumor grade, lymph node status, and tumour node metastasis (TNM) stage of cases.

Results:
Mean ± standard deviation for platelet count, PDW, MPV, P-LCR, PCT, PNR, PLR and PMR among cases were 315.03 ± 98.26, 10.94 ± 1.66, 9.91 ± 0.77, 23.52 ± 5.64, 0.31 ± 0.086, 62.55 ± 31.51, 149.34 ± 61.32, and 498.67 ± 194.91, respectively, and among controls were 287.88 ± 74.11, 10.84 ± 1.18, 9.89 ± 0.72, 23.45 ± 4.55, 0.29 ± 0.061, 60.27 ± 21.02, 138.71 ± 49.28, and 497.64 ± 172.28, respectively. The association between means of platelet count, PDW, P-LCR, and PCT among cases and controls were statistically significant (P = 0.020, 0.006, 0.030, and 0.000, respectively). No statistically significant association was found between means of platelet count, PDW, MPV, P-LCR, PCT, PNR, PLR, and PMR versus tumor size, lymph node status, and tumor grades. The association between the means of PCT/PMR and TNM Stages I and II were statistically significant (P = 0.029 and 0.016, respectively).

Conclusions:
Platelet count, morphology, and functions are altered in oral SCC. Platelet activation plays an important role in oral cancer. PCT and PMR can be used to predict the progress of oral SCC as a cost-effective inflammatory marker.
Resource Use and Food Security in the Republic of Serbia
Authors: Kovljenić Mina , Nestorov Bizonj Jelena 
Published: June 2022

Achieving food security and resources sustainability have a high priority in agrarian policy that universal for all economies. Today modern agriculture has many complex challenges, so a sustainable agriculture approach is needed. Agriculture now must produce more food, using available natural resources efficiently and sustainably, including a reduction of post-harvest losses and waste, and developing agriculture more resilient to climate change. The Republic of Serbia has a good quality of agricultural land, favorable ratio of available land per capita, and favorable climate conditions for agricultural production. However, Serbia has a large number of small farms with fragmented property, family workforce, low level of technical equipment and capital, which have a high production costs and irrational use of resources. The aim of this paper is to examine the impact ofresource use on the level of food security in the Republic of Serbia. The survey data were taken from the FAOSTAT database, World Bank, as well as the national statistics of the Republic of Serbia and hierarchical regression analysis was used. The results of the research have shown that resource supply has a statistically significant impact on the level of food security in the Republic of Serbia.
The Roles of Organizational Culture, Participative Leadership, Employee Satisfaction & Work Motivation Towards Organizational Capabilities
Authors: Aurelia Inezia , Musa Soebowo 
Published: June 2022

Many firms still fail to develop organizational agility. There are more than 40% of organizations think that they are low/not agile in facing market change. Organizational culture plays an important role in developing the organizations to be adaptive in order to manage the VUCA effectively. This study examines the relationships of organizational culture towards participative leadership, employee satisfaction, employee work motivation, organizational learning, and absorptive capacity in developing organizational agility in managing VUCA environment. 263 employees located from an international chemical-based company offices across the globe, who have worked more than three years were the respondents in this study. This study showed that organizational clan culture promotes the development of participative leadership, which it has an empowering effect towards people in the organization resulting in employee satisfaction. The study also confirms the role of organizational culture in creating organizational behavior within the organization that foster the organizational learning, absorptive capacity, and organizational agility; while the study also found that the relationship between participative leadership and employee work motivation is not significant.
Deficiency of Vitamin B12 in Type 2 Diabetic Patients Receiving Metformin Therapy at HMC Hospital Peshawar
Authors: Afridi Muhammad Hussain , Khan Muhamamd Naeem , Khan Atta Muhammad , Abbass Muhammad , Khan Muhammad Khalid , Gul Wali , Zaib Shah 
Published: June 2022

Background: Diabetes mellitus is on the rise at an alarming rate, and it has now become a global issue. Type 2 Diabetic Mellitus is a disease characterized by disturbances in glucose, protein, and fat metabolism. Diabetes has been increasingly common in recent decades, causing significant socioeconomic burden, particularly in poorer countries.
Objective: To investigate the prevalence of vitamin B12 deficiency in Type 2 diabetes patients taking metformin.
Methodology: This study was conducted on T2 diabetic patients in the Diabetic Department of Diabetes and Endocrinology HMC Hospital, Peshawar, for a year (10 February 2019 to 12 March 2020). The demographic data of the recruited patients was obtained after they gave their informed written consent. Patients inquired about their metformin use history, dosage, and duration of type 2 diabetes mellitus. A 5cc venous blood sample was taken from the arm and kept at 4 degrees Celsius. Vitamin B12 levels were measured using enzyme-linked immunoassay assays after serum was withdrawn. ELISA was used to determine the Vitamin B12 level in serums.
Results: A total of 149 people were enrolled in this trial. The patients' average age was 55 years. In this study, there were 67 (38.8%) males and 82 (55.2%) females. The individuals had a 5.12-year history of diabetes mellitus. The average HbA1c level was 8.280.32. The individuals that were included have taken metformin for at least 4.8 years. There were 25 (22.6%) patients using 1000-1500 mg metformin daily, 76 (46.4%) receiving 1500-2000 mg metformin daily, and 48 (40.7%) taking greater than 2000 mg metformin daily. There were 44 patients with a normal BMI, 80 patients who were overweight, and 25 patients who were obese. The average B12 level in the blood was 223pg/ml. Vitamin B12 deficiency was found in 96 (49.1%) of the patients. There was no vitamin B12 deficiency in 53 (45.4%) of the patients.
Recommendations: It is strongly advised based on the findings of this study that Serum cobalamin levels should be measured in Type II diabetes patients who are taking metformin, and patients should be given R.D.A (Recommended Dietary Allowance) multivitamins to avoid sequaela of cobalamin deficiency.
OS EFEITOS DO MICROAGULHAMENTO E LASER DE BAIXA INTENSIDADE NA ALOPECIA ANDROGÉNETICA MASCULINA: REVISÃO INTEGRATIVA
Authors: Morais Santana Ingrid Carolynny , Figueiredo Leão Karen Julyanna , Almeida de Lima e Silva Danielly Karoline de , Lima da Silva Luciane 
Published: June 2022

A Alopecia Androgenética (AAG) é um processo de queda de cabelo progressiva, afetando assim pessoas com mais predisposição genéticas, a maioria sendo homens, trazendo em alguns casos, baixo autoestima, ansiedade e depressão. Tendo em vista toda a questão, o estudo vem trazendo como objetivo um novo tratamento para a AAG, sendo o microagulhamento associado ao laser de baixa intensidade. Metodologia: Trata-se de uma revisão integrativa, realizado com buscas dos artigos científicos nas bases de dados Scientific Electronic Library Online (SciELO), Google Acadêmico, Biblioteca Virtual da Saúde (BVS), Sistema Online de Busca e Análise de Literatura Médica (MEDLINE) e PubMed. Conclusão: Os resultados coletados na revisão integrativa da literatura foram satisfatórios, de forma onde mostra o processo de microagulhamento e o laser de baixa intensidade de forma segura e eficaz no tratamento da Alopecia Androgenética (AAG).
Antenna Array Miniaturization using a Defected Ground Structure
Authors: Kumar Shashi D. , Suganthi Sellakkutti 
Published: June 2022

A novel Defected Ground Structure (DGS) is proposed to miniaturize a 2×2 Modified Corporate Feed Planar Antenna Array (M-CFPA) with a modified corporate feeding network. The DGS altered the surface current distribution and shifted the resonance frequency to the lower side. After running a parametric sweep of length and width of the patch antenna element, achieved the miniaturized antenna array resonating at 2.4 GHz frequency. The proposed antenna array is designed using Rogers/RT Duroid 5,880 ( ) substrate with a thickness of 1.6 mm. The overall dimensions of the proposed Planar Array with DGS (PA-DGS) is 25.2723 % lesser than M-CFPA. The M-CFPA has a peak gain of 11.53 dB with a - 10 dB reflection coefficient bandwidth of 118 MHz. The proposed PA-DGS array exhibits a peak gain of 9.51 dB with 100 MHz -10 dB bandwidth.
HIGHLIGHTS

One of the major challenges faced in antenna array design is creating an efficient feed network
An optimum feed network is designed to miniaturize the antenna array
Metamaterial structures are deployed as defects in the ground plane to achieve further miniaturization

GRAPHICAL ABSTRACT
Use of Course-based undergraduate research experiences model to enhance research interest of Hong Kong health professional undergraduate students
Authors: Yau Yin Chun Mabel , Cheung Tsz Shan Edith , Chen Xiangyan Fiona , Wong Chi-Ming 
Published: June 2022

It has been not easy to recruit postgraduate students from graduates of health professionals programmes in Hong Kong. Recent studies show that Course-based undergraduate research experiences (CURE) not only promote students’ acquisition of research abilities and collaboration skills, but also changes in their career choices and attitude. In this study, we attempted to offer CUREs to students of Medical Laboratory Science programme in our institute as extra-curricular activities to arouse their interest in scientific investigations. They participated to learn research methods, laboratory techniques and get hands-on research experience. The outcomes were evaluated with the CUREs Survey developed by Prof. David Lopatto of Grinnell College and focus group discussion. Results of CUREs survey reveal students obtaining positive gains from the CUREs programme with the relevant learning experience. Similar to previous studies, CUREs participants develop content knowledge, confidence, skills in research and confirm their interest in pursuing science-research related educational or career paths.
Teaching Data-Enabled Design: Student-led Data Collection in Design Education
Authors: Noortman Renee , Lovei Peter , Funk Mathias 
Published: June 2022

Designers are increasingly engaging with data practices in their day-to-day work as design practice becomes increasingly connected. To facilitate this practice, design education needs to evolve and embrace data design. In this paper we introduce a Master-level elective course around the Data-enabled Design methodology. This challenge-based learning activity aims to teach how to use data as a creative material in addressing a real-life design challenge from selected industrial partners. In this article we demonstrate how our master students learn how to prototype, conduct data-enabled interviews, adapt their prototypes, and introduce design interventions via a multi-step approach, leveraging their growing knowledge and skills around contextual data. We share how we use a strong collaboration with our industrial partners and a predefined data infrastructure to help our students use data for sharing valid research findings and presenting experiential interventions.
Community-engaged design studios: learning through “live” projects
Authors: Panayi Christina , Charalambous Nadia 
Published: June 2022

The paper reflects on a pilot community-engaged pedagogical approach underpinned by Urban Living Labs (ULLs) methodology, developed through a second-year housing design studio at the Department of Architecture, University of Cyprus in the spring semester 2021. Through participatory action research methodology (PAR) a co-creation framework was designed, implemented and evaluated and its impact on students and the design result has been assessed. As a meeting place for a quadruple helix of students, educators, researchers, and external stakeholders, the design studio aims to bring together architectural research, pedagogy and society for knowledge exchange and co-production as well as for increasing sustainability, diversity and inclusivity regarding urban decision-making processes. Reflecting on the results, various suggestions for improvements are proposed in terms of the outcome, levels of involvement, tools, process and schedule.
Attracting Viewers through Advertisement by Using Code Mixing: A Sociolinguistics Study
Authors: Herman Herman , Thao Nguyen Van , Purba Ridwin , Simanjuntak Novi Sri Ulina 
Published: June 2022

The artcile aims to clarify what types of code mixes are used in TV advertisements and why code mixing is used because a trend or style of speech in society, particularly among young people has evolved in the phenomenon of mixing code and changing code. Bilingualism always involves the use of code mixing in the daily conversation of people. This research was carried out with a qualitative description. The research used transcript by note as an instrument, for the purpose of this research. Note that the video transcription method was used. The information is 30 ads. Data from this research were all published on Tuesday, 1 June 2021, through Saturday 6 June 2021, by the 30 television ads selected by the researchers. The result is a compatible lexicalization and insertion which appears as types of code mixing in the advertising. and 4 reasons were found, namely talking on a specific subject, interjection, intention to clarify the content of the speech and group identity expression.
Keywords: Sociolinguistic, Code Mixing, Advertisement Analysis
Diagnostic survey on utilization of Kanwa by ruminant livestock farmers in Sokoto state, Nigeria
Authors: Adulkarim A. , Aljameel K. M. , Maigandi S. A. , Na-Allah Y. 
Published: June 2022

This study examined the utilization of hydrated sodium carbonate (Kanwa) by farmers in Sokoto state. A survey was conducted in the three ADP zones of Sokoto state, each represented by three Local Government Areas to assess farmers' utilization of Kanwa on livestock production. The data collected in experiment were analysed using simple descriptive statistics. The result of the survey shows that 94.17% of the respondents offer Kanwa to their animals. Majority use Balma (32.74%), other types of Kanwa used by the respondents include Burunguzu (9.73%), table salt (19.47%), Hogga (5.3%) and Jan gishiri (0.88%).

Cette étude a examiné l'utilisation du carbonate de sodium hydraté (Kanwa) par les agriculteurs de l'État de Sokoto. Une enquête a été menée dans les trois zones ADP de l'État de Sokoto, chacune représentée par trois zones de gouvernement local pour évaluer l'utilisation par les agriculteurs de la production animale de Kanwa. Les données recueillies dans l'expérience ont été analysées à l'aide de statistiques descriptives simples. Le résultat de l'enquête montre que 94,17% des répondants offrent le Kanwa à leurs animaux. La majorité utilise le Balma (32,74 %), les autres types de Kanwa utilisés par les répondants incluent le Burunguzu (9,73 %), le sel de table (19,47 %), le Hogga (5,3 %) et le Jan gishiri (0,88 %).
Distribution and stable carbon isotopic composition of dicarboxylic acids, ketocarboxylic acids and α-dicarbonyls in fresh and aged biomass burning aerosols
Authors: Shen Minxia , Ho Kin Fai , Dai Wenting , Liu Suixin , Zhang Ting , Wang Qiyuan , Meng Jingjing , Chow Judith C. , Watson John G. , Cao Junji , Li Jianjun 
Published: June 2022

Abstract. Biomass burning (BB) is a significant source of dicarboxylic acids
(diacids) and related compounds that play important roles in atmospheric
chemistry and climate change. In this study, a combustion chamber and
oxidation flow reactor were used to generate fresh and aged aerosols from
burned rice, maize and wheat straw to investigate atmospheric aging and the
stable carbon isotopic (δ13C) composition of these emissions.
Succinic acid (C4) was the most abundant species in fresh samples,
while oxalic acid (C2) became dominant after atmospheric aging. Of all
diacids, C2 had the highest aged to fresh emission ratios (A/F),
suggesting that C2 is largely produced through secondary photochemical
processes. Compared with fresh samples, the emission factors of
ketocarboxylic acids and α-dicarbonyls increased after 2 d but
decreased after 7 d aging, indicating a short residence time and further
atmospheric degradation from 2 to 7 d. The δ13C values of
C2 for aged biomass samples were higher than those of urban aerosols
but lower than marine or mountain aerosols, and the δ13C values
of C2 became isotopically heavier during aging. Relationships between
the reduction in volatile organic compounds (VOCs), such as toluene,
benzene and isoprene, and increase in diacids after 2 d aging indicate
that these VOCs led to the formation of diacids. However, no significant
correlation was found between decreases in VOCs and increases in 7 d aged
diacids. In addition, the A/F of C2 was 50.8 at 2 d and 64.5 at 7 d, indicating that the conversion of VOCs to C2 was almost completed
within 2 d. For the longer aging times, the particulate-phase compounds
may undergo further degradation in the oxidation processes.
The “SafeSpace” database of ULF power spectral density and radial diffusion coefficients: dependencies and application to simulations
Authors: Katsavrias Christos , Nasi Afroditi , Daglis Ioannis A. , Aminalragia-Giamini Sigiava , Dahmen Nourallah , Papadimitriou Constantinos , Georgiou Marina , Brunet Antoine , Bourdarie Sebastien 
Published: June 2022

Abstract. Radial diffusion has been established as one of the most important
mechanisms contributing to both the acceleration and loss of
relativistic electrons in the outer radiation belt, as well as to the
supply of particles to the inner radiation belt. In the framework of
the “SafeSpace” project, we have used 9 years (2011–2019) of multi-point
magnetic and electric field measurements from THEMIS A, D and E
satellites to create a database of radial diffusion coefficients
(DLL) and ultra-low-frequency (ULF) wave power spectral densities
(PSDs) spanning an L∗ range from 3 to 8. In this work we
investigate the dependence of the DLL on the various solar wind
parameters, geomagnetic indices and coupling functions, as well as the
L-shell, during the solar cycle 24. Moreover, we discuss the
uncertainties introduced on the estimation of DLL time series by
the partial azimuthal coverage provided by in situ
measurements. Furthermore, we investigate, via a superposed analysis,
the dependence of the DLL on solar wind drivers. We show, for the
first time to the best of our knowledge, that the interplanetary coronal mass
ejection (ICME)-driven disturbances accompanied by high solar wind
pressure values combined with intense magnetospheric compression can
produce DLLB values comparable to or even greater than the
ones of DLLE. This feature cannot be captured by
semi-empirical models and introduces a significant energy dependence
on the DLL. Finally, we show the advantages of using DLL
time series by means of numerical simulations of relativistic electron
fluxes performed with the Salammbô code and significant deviations in the predictions of several semi-empirical models depending on the level of geomagnetic activity and L-shell.
Transient climate simulations of the Holocene (version 1) – experimental design and boundary conditions
Authors: Tian Zhiping , Jiang Dabang , Zhang Ran , Su Baohuang 
Published: June 2022

Abstract. The Holocene, which started approximately 11.5 ka, is the latest interglacial period with several rapid climate changes with timescales, from decades to centuries, superimposed on the
millennium-scale mean climate trend. Climate models provide useful tools to
investigate the underlying dynamic mechanisms for the climate change during
this well-studied time period. Thanks to the improvements in the climate
model and computational power, transient simulation of the Holocene offers
an opportunity to investigate the climate evolution in response to
time-varying external forcings and feedbacks. Here, we present the design of a new set of transient experiments for the whole Holocene from 11.5 ka to the preindustrial period (1850; HT-11.5 ka) to investigate both the combined and separated effects of the main external forcing of orbital insolation, atmospheric greenhouse gas (GHG) concentrations, and ice sheets on the climate evolution over the Holocene. The HT-11.5 ka simulations are performed with a relatively high-resolution version of the comprehensive Earth system model CESM1.2.1 without acceleration, both fully and singly forced by time-varying boundary conditions of orbital configurations, atmospheric GHGs, and ice sheets. Preliminary simulation results show a slight decrease in the global annual mean surface air temperature from 11.5 to 7.5 ka due to both changes in orbital insolation and GHG concentrations, with an abrupt cooling at approximately 7.5 ka, which is followed by a continuous warming until the preindustrial period, mainly due to increased GHG concentrations. Both at global and zonal mean scales, the simulated annual and seasonal temperature changes at 6 ka lie within the range of the 14 PMIP4 model results and are overall stronger than their arithmetic mean results for the Middle Holocene simulations. Further analyses on the HT-11.5 ka transient simulation results will be covered by follow-up studies.
One Focalization, Dual Progression, and Twofold Irony
Authors: Shen Dan 
Published: June 2022

ABSTRACT
Despite extensive theoretical and critical attention paid to focalization, no effort has been made to discuss how one mode of focalization simultaneously helps convey two contrastive kinds of irony. This is ascribable to three factors. First, such a phenomenon is not often seen. Second, if it occurs, it would take place at once in relation to the overt progression and to a covert progression, but critical attention has not extended to the latter. Third, investigations of both focalization and irony have not yet considered their taking on contrastive functions along different thematic trajectories. This essay explores this previously neglected phenomenon with the illustration of Katherine Mansfield’s “A Dill Pickle,” a narrative focusing on the relationship between a man and a woman. The essay reveals that the woman’s focalization conveys irony not only at the male protagonist in the plot-based overt progression but also at the woman herself in a paralleling covert progression.