bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rhesus macaques compensate for reproductive delay following ecological adversity early in life
Authors: Luevano Logan , Sutherland Chris , Gonzalez Stephanie J. , Hernández‐Pacheco Raisa 
Published: January 2022

AbstractAdversity early in life can shape the reproductive potential of individuals through negative effects on health and life span. However, long‐lived populations with multiple reproductive events may present alternative life history strategies to optimize reproductive schedules and compensate for shorter life spans. Here, we quantify the effects of major hurricanes and density dependence as sources of early‐life ecological adversity on Cayo Santiago rhesus macaque female reproduction and decompose their effects onto the mean age‐specific fertility, reproductive pace, and lifetime reproductive success (LRS). Females experiencing major hurricanes exhibit a delayed reproductive debut but maintain the pace of reproduction past debut and show a higher mean fertility during prime reproductive ages, relative to unaffected females. Increasing density at birth is associated to a decrease in mean fertility and reproductive pace, but such association is absent at intermediate densities. When combined, our study reveals that hurricanes early in life predict a delay‐overshoot pattern in mean age‐specific fertility that supports the maintenance of LRS. In contrast to predictive adaptive response models of accelerated reproduction, this long‐lived population presents a novel reproductive strategy where females who experience major natural disasters early in life ultimately overcome their initial reproductive penalty with no major negative fitness outcomes. Density presents a more complex relation with reproduction that suggests females experiencing a population regulated at intermediate densities early in life will escape density dependence and show optimized reproductive schedules. Our results support hypotheses about life history trade‐offs in which adversity‐affected females ensure their future reproductive potential by allocating more energy to growth or maintenance processes at younger adult ages.
Effect of early intervention on short‐term prognosis of patients with myocardial injury induced by acute carbon monoxide poisoning
Authors: Li Baiyan , Gao Xun , Wang Weizhan , Zhu Baoyue , Xiao Qingmian 
Published: January 2022

AbstractAimThis study aimed to investigate the effect of early intervention on the short‐term prognosis of patients with myocardial injury induced by acute carbon monoxide poisoning (ACOP).Methods and resultsWe performed a retrospective cohort study of 139 patients admitted to the hospital for ACOP‐induced acute toxic cardiopathy. Compared with the mild and moderate toxic cardiopathy group, the severe toxic cardiopathy group has significantly increased coma time, acute physiology and chronic health status (APACHE) II score, and the length of hospital stay and significantly reduced proportion of patients with immediate endotracheal intubation and early admission to intensive care unit (ICU) (all P < 0.05). The cardiac troponin I (cTnI) levels and corrected QT dispersion (QTcd) duration in three patient groups were significantly higher (all P < 0.05) than those in the control group, with the highest in the severely toxic heart disease group. Serum cTnI level and QTcd duration were two independent predictors of myocardial injury in ACOP patients. There was a positive correlation between the APACHE II score and serum cTnI level/QTcd duration at admission. The sensitivities of cTnI and QTcd at admission to diagnose serious cardiovascular events were 78.6% and 85.7%, respectively, and the specificities were both 75%.ConclusionsAcute carbon monoxide poisoning patients with myocardial injury need to be admitted to the hospital as early as possible. For patients with severe hypoxia, an artificial airway should be established as early as possible, and patients should be admitted to the monitoring ward to stabilize their condition at the early stage of poisoning. Meanwhile, changes in QTcd, serum cTnI, and creatine kinase‐MB (CK‐MB) should be closely observed.
1,2‐Boryl Migration Enables Efficient Access to Versatile Functionalized Boronates
Authors: Jiang Xia‐Min , Liu Xin‐Ru , Chen Ang , Zou Xi‐Zhang , Ge Jian‐Fei , Gao De‐Wei 
Published: January 2022

AbstractOrganoboronates are synthetically useful and highly valuable building blocks in synthetic and medicinal chemistry. Two‐electron reactions allow for the rapid construction of organoboronates via nucleophilic 1,2‐boron shift of boron ate complexes or MIDA‐mediated 1,2‐boryl migration. Radical approaches through 1,2‐boron shift of neutral boronic esters or boron ate complexes have been demonstrated to be feasible, providing complementary methods to access these privileged scaffolds. In this Review, recent achievements are highlighted and future opportunities are discussed, with an emphasis on different operative modes of catalysis and reaction pathways.
Emerging contaminant exposure to aquatic systems in the Southern African Development Community
Authors: Selwe Kgato P. , Thorn Jessica P. R. , Desrousseaux Alizée O. S. , Dessent Caroline E. H. , Sallach J. Brett 
Published: January 2022

Abstract
The growing production and use of chemicals and the resultant increase in environmental exposure is of particular concern in developing countries where there is rapid industrialization and population growth but limited information on the occurrence of emerging contaminants. Advances in analytical techniques now allow for the monitoring of emerging contaminants at very low concentrations with the potential to cause harmful ecotoxicological effects. Therefore, we provide the first critical assessment of the current state of knowledge about chemical exposure in waters of the Southern African Developmental Community (SADC). We achieved this through a comprehensive literature review and the creation of a database of chemical monitoring data. Of the 59 articles reviewed, most (n = 36; 61.0%) were from South Africa, and the rest were from Botswana (n = 6; 10.2%), Zimbabwe (n = 6; 10.2%), Malawi (n = 3; 5.1%), Mozambique (n = 3; 5.1%), Zambia (n = 2; 3.4%), Angola (n = 1; 1.7%), Madagascar (n = 1; 1.7%), and Tanzania (n = 1; 1.7%). No publications were found from the remaining seven SADC countries. Emerging contaminants have only been studied in South Africa and Botswana. The antiretroviral drug ritonavir (64.52 µg/L) was detected at the highest average concentration, and ibuprofen (17 times) was detected most frequently. Despite being the primary water source in the region, groundwater was understudied (only 13 studies). High emerging contaminant concentrations in surface waters indicate the presence of secondary sources of pollution such as sewage leakage. We identify research gaps and propose actions to assess and reduce chemical pollution to enable the SADC to address the Sustainable Development Goals, particularly Goal 3.9, to reduce the deaths and illnesses from hazardous chemicals and contamination. Environ Toxicol Chem 2022;41:382–395. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
A Multidimensional Matrix Model for Predicting the Effects of Male-Biased Sex Ratios on Fish Populations
Authors: Miller David H. , Villeneuve Daniel L. , Santana-Rodriguez Kelvin J. , Ankley Gerald T. 
Published: January 2022

Abstract
Laboratory experiments have established that exposure to certain endocrine-active substances prior to and/or during the period of sexual differentiation can lead to skewed sex ratios in fish. However, the potential long-term population impact of biased sex ratio depends on multiple factors including the life history of the species and whether the ratio is male or female-biased. In the present study, we describe a novel multidimensional, density-dependent matrix model that analyzes age class-structure of both males and females over time, allowing for the quantitative evaluation of the effects of biased sex ratio on population status. This approach can be used in conjunction with field monitoring efforts and/or laboratory testing to link effects on sex ratio due to chemical and/or nonchemical stressors to adverse outcomes in whole organisms and populations. For demonstration purposes, we applied the model to evaluate population trajectories for fathead minnow (Pimephales promelas) exposed to prochloraz, an aromatase inhibitor, during sexual differentiation. The model also was used to explore the population impact in a more realistic exposure scenario in which both adult and early life stages of fish are exposed concurrently to prochloraz, which, in addition to altering sex ratio during development, can decrease vitellogenin and egg production in adult females. For each exposure scenario, the model was used to analyze total population size, numbers of females and of males, and sex specific recruitment of the F1 generation. The present study illustrates the utility of multidimensional matrix population models for ecological risk assessment in terms of integrating effects across a population of an organism even when chemical effects on individuals are manifested via different pathways depending on life stage. Environ Toxicol Chem 2022;41:1066–1077. Published 2022. This article is a U.S. Government work and is in the public domain in the USA.
Development of male breast cancer in a patient with prostate cancer during androgen deprivation therapy
Authors: Mizusawa Hiroya , Komatsu Akira , Mimura Yuji , Maejima Toshitaka 
Published: January 2022

IntroductionMale breast cancer accounts for <1% of all breast cancer. We report a patient with prostate cancer during hormone therapy who developed breast cancer.Case presentationAn 88‐year‐old male underwent androgen deprivation therapy for prostate cancer and developed an induration in the left breast 7 years after the start of treatment. After close examination, he was diagnosed with left breast cancer with lymph node metastasis. The prostate cancer was stable in a hormone‐sensitive state. Left mastectomy was performed and the pathological diagnosis was invasive ductal carcinoma.DiscussionIn addition to our patient, seven patients who developed breast cancer during hormone therapy for prostate cancer were examined. Five of six patients had stage II or above, and four patients had lymph node metastases. Although local breast symptoms are frequently observed as adverse effects of hormone therapy, caution is warranted regarding male breast cancer.
New Challenges and Advances in Systems Engineering at French Universities
Authors: Gouyon David , Panetto Hervé 
Published: January 2022

ABSTRACTThis special issue of INSIGHT highlights the ninth edition of the French Systems Engineering Academia‐Industry meetings, organized by AFIS (Association Française d'Ingénierie Système), the French chapter of INCOSE, and supported by French universities as a regular series, usually every two years. Due to the COVID‐19 crisis, this edition occurred virtually in December 2020.These meetings, which are composed of workshops and plenary lectures, provides the opportunity for both academics and industrials to: debate on systems engineering practices, education, and competences development for professional situations, and develop and promote research in systems engineering.
Using Synthesis and Analysis for Design in Systems Engineering: an Integrated Approach
Authors: Diampovesa Sephora , Yvars Pierre‐Alain , Hubert Arnaud 
Published: January 2022

ABSTRACTThis article presents a complete and general approach for the preliminary design of systems in the framework of systems engineering by relying mainly on synthesis. It is completed by a validation step through analysis to reduce furthermore the space of admissible solutions. This approach focuses on the modeling of design problems in electrical engineering and of their solving by including non‐functional requirements right from the start through a single process. Starting from the specification of the requirements, the proposed approach develops the construction of synthesis models of design problems and their solving using the DEPS problem modeling language and the DEPS Studio environment based on Constraint Programming and Object‐oriented modeling. Concepts related to this approach include in particular the issue of reusability of models, notions of subdefinite systems and of problem, knowledge and solutions spaces.
Harmonica: A Framework for Semi‐automated Design and Implementation of Blockchain Applications
Authors: Six Nicolas , Herbaut Nicolas , Salinesi Camille 
Published: January 2022

ABSTRACTDesigning blockchain‐based applications is a tedious task. Compared to traditional software engineering, software architects cannot rely on previous experiences or proven practices, often formalized as software patterns. Also, the selection of an adequate blockchain technology is difficult without deep knowledge of the technology. This paper introduces Harmonica, a framework for the design and implementation of a blockchain‐based application. This framework is divided in three parts: a decision‐making engine to recommend a blockchain technology and blockchain‐based software patterns relying on requirements, a configurator to generate code stubs and configuration files, and a knowledge base to support those tools.
Comparison of hematopoietic progenitor cell collection using different inlet flow rates with the Fenwal Amicus
Authors: Burgstaler Edwin A. , Bryant Sandra C. , Winters Jeffrey L. 
Published: January 2022

AbstractPurposeWe have used a hematopoietic progenitor cell (HPC) algorithm (standard [STD]) that restricted the inlet flow rate to 65 mL/min for peripheral white blood cell count (PWBC) >35 × 109/L (STD). In this study, we evaluated a technique that allows 85 mL/min, regardless of the PWBC count (high). For patients with PWBC >35 × 109/L, a prospective, randomized comparison of the high flow rate vs the STD PWBC‐based flow rate (65 mL/min) was performed, comparing CD34+ and lymphocyte yields, collection efficiencies (CE1), mononuclear cells (MNC), and granulocytes, red blood cell (RBC), and platelet content.MethodsThe Fenwal Amicus version 4.5 with a heparinized ACD‐A anticoagulant (AC) delivered at a 26:1 AC ratio was used. Paired comparisons between high and STD techniques were assessed with Wilcoxon signed rank tests, with P < .05 considered significant. Data are summarized as medians.ResultsForty patient pairs (autologous) were compared. Diagnoses included primarily multiple myeloma (60%) and lymphoma (37.5%). High had significantly higher median average inlet rates (69 vs 55 mL/min), whole blood processed (20 vs 16 L), and cycles (15 vs 14) than STD. There were no significant differences in pre‐procedure counts. Collection contents were (high/STD): 306/328 × 106 CD34+ cells, 48/59% CD34+ CE1 (significant), 0.2/0.2 × 109/kg lymphocytes, 45/57% lymphocyte CE1, 63/59 × 109 WBC, 15/16 × 109 granulocytes, and 1.9/1.7 × 1011 platelets.ConclusionsThe simpler, standardized high flow technique did not significantly increase or decrease CD34+ cells or lymphocyte yields, but did significantly decrease CD34+ CE1. The effects on cross‐cellular content were minimal and not clinically significant.
A review on new ammonium oxidation alternatives for effective nitrogen removal from wastewater
Authors: Zhao Shan , Feng Shi‐Jin , Wu Cong‐Cong , Zhang Jian , Chen Kang‐Ping 
Published: January 2022

AbstractAs a highly oxidizing ion, ammonium (NH4+) is easily reduced by other reducing substances. Recently, NH4+ oxidation coupled with Fe3+, SO42−, and Mn4+ reduction (i.e., Feammox, Sulfammox, and Mnammox) has been confirmed and their collaborative roles in removing NH4+ have been revealed in several studies. However, only limited knowledge could be obtained on observed interactions with several variable parameters due to the exiguous research in this field, which makes it challenging to draw basic and mechanistic conclusions. This review focuses on these new NH4+ oxidation alternatives and provides a systematic and comprehensive overview of recent advances in these processes. Specifically, based on the summaries of their reaction conditions, nine influencing factors (including microorganisms, concentrations of reactants, pH, redox potential, temperature, organic carbon, oxygen concentration, salinity, and inhibitory substances) are discussed in detail. Then, the drawbacks of the three processes are pointed out. The results show that, at present, the practical engineering applications for NH4+ removal are not suitable due to their harsh reaction conditions and low removal efficiency. Finally, suggestions for further research on these processes are presented to inspire more interest from researchers in related fields and to promote and realize their large‐scale engineering application in the near future. © 2022 Society of Chemical Industry (SCI).
Sonographic pulmonary response after tracheal occlusion in fetuses with severe isolated congenital diaphragmatic hernia
Authors: Trad Ayssa Teles Abrao , Czeresnia Ricardo , Ibirogba Eniola , Narang Kavita , Ruano Rodrigo 
Published: January 2022

AbstractPurposeTo report the longitudinal lung growth and prognosis of fetuses with severe left sided congenital diaphragmatic hernia (CDH) treated with fetoscopic tracheal occlusion (FETO) in a single institution.MethodsFetal lung size (observed‐to‐expected lung area to head circumference [o/e‐LHR]) was measured in seven consecutive fetuses with isolated severe left‐sided CDH who underwent FETO. Fetal lung growth was used to prognosticate survival and need for ECMO.ResultsSeven consecutive fetuses had a FETO procedure in the timeframe of this study. A total of 44 longitudinal ultrasound were performed to evaluate lung development. FETO was performed at GA 28.5 ± 0.5 weeks. Five (71.4%) infants survived to one‐year follow‐up and ECMO was needed in three patients (42.8%). Fetal lung response was observed in all fetuses; mean o/e‐LHR increased from 22.5% ± 1.4 before FETO to 44.4% ± 9.8 before delivery. Infants who survived had a higher percentage of fetal lung growth (21.8%) than those who died (8.25%).ConclusionOur study supports the hypothesis that FETO promotes fetal lung growth in fetuses with severe left‐sided CDH, and the fetal pulmonary response seems to be associated with improved outcomes after the procedure.
Conceptualising inclusive development by identifying universality, plurality, sociality, and relationality
Authors: Johnstone Christopher J. 
Published: January 2022

AbstractThis article aims to conceptualise contemporary understandings of ‘inclusive development’. The article draws upon two conceptual models: plural/universal rights (Mégret, 2008, 10.1353/hrq.0.0000) and social–relational inclusion (Gupta & Vegelin, 2016, https://doi.org/10.1007/s10784-016-9323-z) to demonstrate how ‘inclusion’ is understood concerning economic, social, and human development. The article then draws upon these disparate, yet interconnected understandings of inclusive development and maps four contemporary inclusive development approaches (participation of stakeholders, representational politics, social protection, and economic redistribution). The purpose of this mapping is to provide context for how the singular word ‘inclusion’ can be used to pursue multiple desired outcomes, some of which may conflict with one another.
Limbal Bio‐Engineered Tissue Employing 3D Nanofiber‐Aerogel Scaffold to Facilitate LSCs Growth and Migration
Authors: Tan Yongyao , Chen Dan , Wang Yunming , Wang Wei , Xu Lingjuan , Liu Rong , You Chunxiu , Li Guigang , Zhou Huamin , Li Dequn 
Published: January 2022

AbstractConstrained by the existing scaffold inability to mimic limbal niche, limbal bio‐engineered tissue constructed in vitro is challenging to be widely used in clinical practice. Here, a 3D nanofiber‐aerogel scaffold is fabricated by employing thermal cross‐linking electrospinned film polycaprolactone (PCL) and gelatin (GEL) as the precursor. Benefiting from the cross‐linked (160 °C, vacuum) structure, the homogenized and lyophilized 3D nanofiber‐aerogel scaffold with preferable mechanical strength is capable of refraining the volume collapse in humid vitro. Intriguingly, compared with traditional electrospinning scaffolds, the authors’ 3D nanofiber‐aerogel scaffolds possess enhanced water absorption (1100–1300%), controllable aperture (50–100 µm), and excellent biocompatibility (optical density value, 0.953 ± 0.021). The well‐matched aperture and nanostructure of the scaffolds with cells enable the construction of limbal bio‐engineered tissue. It is foreseen that the proposed general method can be extended to various aerogels, providing new opportunities for the development of novel limbal bio‐engineered tissue.
Quantitative Investigation into the Design and Process Parametric Effects on the Fiber‐Entrapped Residual Charge for a Polymer Melt Electrohydrodynamic Printing Process
Authors: Cao Kai , Zhang Fucheng , Zaeri Ahmadreza , Zgeib Ralf , Chang Robert C. 
Published: January 2022

AbstractThe printing accuracy of the melt electrowriting (MEW) process is adversely affected by residual charge entrapped within the printed fibers. To mitigate this effect, the residual charge amount (Qr) must first be accurately determined. In this study, Qr is measured by a commercial electrometer at a nanocoulomb scale for MEW‐enabled scaffolds. Based on this enabling measurement, the effects of various design parameters (including substrate surface conductivity σ, printing time t, layer number N), and process parameters (including voltage U, translational stage speed v, and material temperature Tm), on Qr are investigated. An increase of σ or decrease of N helps to decrease Qr. The effects of different process parameters on the residual charge can be either dependent or independent of fiber morphologies. Moreover, the fiber‐morphology dependent and independent effect can be either synergistic (U and Tm) or antagonistic (e.g., v) for different process parameters. Under same conditions, Qr in the interweaving scaffold design is generally smaller than that in the non‐interweaving scaffold design. These results help to furnish necessary insights into the charge dissipation process for a melt‐based electrohydrodynamic printing process while providing a systematic methodology to mitigate the residual charge accumulation.
Effect of machining and drag finishing on the surface integrity and mechanical properties of Inconel 718 alloys fabricated by laser powder bed fusion additive manufacturing
Authors: Karabulut Y. , Kaynak Y. , Sharif S. , Suhaimi M.A. 
Published: January 2022

AbstractLaser powder bed fusion process is one of the most widely used Additive Manufacturing techniques for fabricating metal components, however the surface quality of such components still remains a challenge and fails to meet the user expectations. Thus, this study presents a systematic investigation on the effect of post‐processing operations including finish milling and drag finishing on the surface integrity and resulting mechanical properties of Inconel 718 specimens fabricated by laser powder bed fusion additive manufacturing technique. The influence of post‐processing operations on the surface and subsurface microstructure, microhardness and tensile strength on the Inconel 718 specimens are carefully examined and presented in this study. Finally, this work also contributes to understanding the critical wall (part) thickness that is notably induced from the post‐processing operations. It is revealed that the surface integrity and resulting mechanical properties of specimens significantly improved as compared to as‐built specimens once milling and drag finishing post‐processing are deployed. However, the degree of impact depends on the thickness of parts subjected to post‐processing.