bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ranibizumab versus aflibercept for macular edema secondary to nonischemic central retinal vein occlusion in young adult patients
Authors: Amer Ahmed Ali , Aldghaimy Ahmed Hasan , Abdellah Marwa Mahmoud , Hassan. Nader Hussein Fouad 
Published: March 2022

Abstract
Purposeto compare effect Ranibizumab and Aflibercept, for the treatment of macular edema secondary to non-ischemic central retinal vein occlusion CRVO in young adults.MethodsForty eyes of 40 young adult patients with macular edema due to CRVO were enrolled in this prospective double-armed clinical trial. The patients were randomized into 2 groups of 20 patients each. First group received intravitreal injection of Ranibizumab while second group received Aflibercept. All patients were subjected to measurement of Best corrected visual acuity BCVA, fluorescein angiography (FA) to detect retinal ischemia and Spectral domain OCT (SD-OCT) to measure macular edema at baseline and during 12-month follow up period. Intravitreal injections were three injections with a 1-month interval between injections.ResultsBCVA in group 1 had significant steady increase over time from baseline to 1 year [55.9 ± 10.3], p = 0.017). Group 2 had also significant steady increase over time from baseline to 1 year [60.8 ± 8.4], p = 0.035) with no significant difference between the 2 groups (p > 0.05). Regarding central subfield thickness CST, in the first group, statistically significant decrease in the CST over time from baseline to 1 year [295.1 ± 56 Um], p < 0.001). similar results in the second group from the baseline to 1 year [328.2 ± 72 Um] with no statistically significant difference (p > 0.05).ConclusionRanibizumab and aflibercept showed a comparable promising outcome in the management of macular edema secondary to nonischemic CRVO in patients aged < 50 years.Trial registration number : NCT05282420
Updating Features In Geo AR Mobile Games To Increase Monthly Active User Base
Authors: LIU Hugh Xuechen , Wagner Christian 
Published: March 2022

Abstract
Geo AR mobile games care about their monthly active users base for the business's success. Previous studies propose that updating the game will increase its monthly active user number base. However, this proposition was not statistically tested. It’s also still unclear what kind of updates work. These questions are essential for a better understanding of the Geo AR mobile game. This paper conducted a chi-squared test with the game Pokémon GO as a context. Surprisingly, general updates do not relate to the monthly active user base. However, the Feature category of updates strongly relates to the base. Therefore, for the survival and the success of the Geo AR mobile games, developers must keep in mind to release Feature updates repeatedly.
Systematic treatment of giant gastroduodenal anastomotic leakage：a case report
Authors: Yang Rui , Wang Yinchun , Yang Yuyi , Yang Qingqiang 
Published: March 2022

Abstract
Background
Gastroduodenal anastomotic leakage is one of the most dreadful complications of gastrectomy and poses a great threat for treatment. However, there has been no effective treatment for it up to now. We report a case, a patient with huge gastroduodenal anastomotic leakage, was eventually recovered after conservative treatment up front and later resolution of anastomotic obstruction through gastrojejunostomy and jejunostomy.
Case presentation:
A 50-year-old man underwent a distal gastrectomy for a giant penetrating ulcer in the lesser curvature of the gastric sinus. Digestive reconstruction was completed by the Billroth I method. But an anastomotic leakage occurred on postoperative day 9 and a high output of duodenal juice was observed, and the following gastroscopy suggested that there was a large breach in the gastroduodenal anastomosis. Because of the patency of the drainage tube and the limitations of the patient's condition, conservative treatment was advocated and a nasojejunal tube was placed under the gastroscope for enteral nutrition. Unexpectedly, during subsequent treatment, persistent hypothermia associated with rheumatoid arthritis, drainage-associated transverse colon leakage and anastomotic stenosis occurred. Eventually, after taking the gastrojejunostomy and jejunostomy and gradually withdrawing and flushing the drainage tube, the patient was able to achieve a tube-free state and eat in the normal way.
Conclusions
The course of the patient’s treatment was continuous and systematic. In this case, we found that conservative treatment was feasible for giant gastroduodenal anastomotic leakage in the presence of patent drainage and limited physical signs. And for secondary anastomotic stenosis, gastrojejunostomy can effectively relieve the obstruction.
The Evidence Synthesis and Meta-Analysis in R Conference (ESMARConf): levelling the playing field of conference accessibility and equitability
Authors: Haddaway Neal , Bannach-Brown Alexandra , Grainger Matthew J. , Hamilton W. Kyle , Hennessy Emily A. , Keenan Ciara , Pritchard Chris C. , Stojanova Jana 
Published: March 2022

Abstract
Rigorous evidence is vital in all disciplines to ensure efficient, appropriate, and fit-for-purpose decision-making with minimised risk of unintended harm. To date, however, disciplines have been slow to share evidence synthesis frameworks, best practices, and tools amongst one another. Recent progress in collaborative digital and programmatic frameworks, such as the free and Open Source software R, have significantly expanded the opportunities for development of free-to-use, incrementally improvable, community driven tools to support evidence synthesis (e.g. EviAtlas, robvis, PRISMA2020 flow diagrams and metadat). Despite this, evidence synthesis (and meta-analysis) practitioners and methodologists who make use of R remain relatively disconnected from one another. Here, we report on a new virtual conference for evidence synthesis and meta-analysis in the R programming environment (ESMARConf) that aims to connect these communities. By designing an entirely free and online conference from scratch, we have been able to focus efforts on maximising accessibility and equity - making these core missions for our new community of practice. As a community of practice, ESMARConf builds on the success and groundwork of the broader R community and systematic review coordinating bodies (e.g. Cochrane), but fills an important niche. ESMARConf aims to maximise accessibility and equity of participants across regions, contexts, and social backgrounds, forging a level playing field in a digital, connected, and online future of evidence synthesis. We believe that everyone should have the same access to participation and involvement, and we believe ESMARConf provides a vital opportunity to push for equitability across disciplines, regions, and personal situations.
Effect of alloying elements on thermal stability of Aluminium-Cerium based alloys
Authors: Saini Dheeraj Kumar , Gope Rahul , Mandal Animesh 
Published: March 2022

Abstract
The strength of aluminum alloy decreases sharply with the increase of temperature. One of the major drawbacks of aluminum alloys is that it does not retain their mechanical properties at higher temperatures. To solve this problem, the high-temperature stability of the Al-Ce system is studied. The effect of alloying elements on the thermal stability of five different near eutectic Al-Ce based alloys, i.e., Al-12Ce, Al-12Ce-4Si, Al-12Ce-0.4Mg, Al-12Ce-4Si-0.4Mg and Al-12Ce-4Si-0.4Mg-0.25Sr alloys, were investigated. The alloys were heat treated at three different temperatures, i.e., 200 °C, 300 °C and 400 °C, to establish thermal stability. Binary Al-12Ce alloy consisting of α-Al and showed higher resistance to coarsening at all temperatures. The addition of Si helps retain the microstructure stability above 200 °C and the combined addition of Si and Mg increases the room and high-temperature strength up to 300 °C. The addition of Sr to quaternary alloy was not beneficial for enhancing thermal stability.
Incidence and Prognostic Implication of Bone Marrow Involvement in Hodgkin’s Lymphoma
Authors: Bansal Rimpi , Kaur Puneet , Sarin Jatin , Kaur Anureet , Sarin Akshita 
Published: March 2022

Introduction- : Conducting Bone marrow examination in a Hodgkin's Lymphoma (HL) patient at the time of diagnosis is done routinely to determine the stage of the disease. The aim of this study was to analyze the incidence and prognosis of bone marrow involvement in patients with Hodgkins lymphoma, retrospectively.
Materials and Patients: Ten patients of Hodgkins lymphoma were incorporated in the current study. Bone marrow aspiration and biopsy was done in all ten cases as part of staging procedure.
Results: Three patients showed involvement of bone marrow by Hodgkin’s lymphoma and both the patients had clinically poor outcome.
Discussion and Conclusion: Bone marrow examination is important in stage II and III of Hodgkin”s lymphoma because positive result will upstage the disease. Also, bone marrow involvement indicates an aggressive disease and poor prognosis for the patient.
Flexibilizar el proceso de enseñanza y aprendizaje en una universidad online
Authors: Mosquera Gende Ingrid 
Published: March 2022

La universidad online puede ser un buen escenario para promover una educación flexible y para fomentar un aprendizaje activo e informal. Sin embargo, para beneficiarse de esta combinación, hace falta formación y una adecuada implementación. La presente investigación hace referencia a una experiencia educativa llevada a cabo en una universidad online con una muestra de 107 estudiantes de Infantil, Primaria y Secundaria. Se trata de una propuesta de aprendizaje activo que tiene como objetivo flexibilizar la educación online por medio de diferentes iniciativas que se desarrollan dentro del marco de una misma materia. La autorregulación, la autonomía, la colaboración, la interacción y el aprendizaje informal conforman una propuesta holística enfocada a mejorar la experiencia educativa del alumnado.
Empleando un cuestionario online, se comprueba que el uso adecuado y frecuente de los foros por parte del profesorado supone un instrumento de ayuda fundamental para los estudiantes. Así mismo, se concluye que la plataforma Edpuzzle contribuye a la flexibilización del proceso de aprendizaje, proporcionando una mayor autonomía y autorregulación al alumnado. Además, la posibilidad de realizar actividades en parejas y el empleo de herramientas digitales también son aspectos a considerar para lograr una educación online más personalizada y flexible.
Respiratory Function Correlates with Fat Mass Index and Blood Triglycerides in Institutionalized Older Individuals
Authors: Martinez-Arnau Francisco Miguel , Buigues Cristina , Fonfría-Vivas Rosa , Cauli Omar 
Published: March 2022

Background:
We investigated the relationship between respiratory function measured by
spirometry analysis and anthropometric variables (skeletal and fat mass) and nutritional status in the
institutionalized elderly, particularly at high-risk for adverse outcomes after respiratory infections and
malnutrition.

Design:
This is a multicenter cross-sectional study with a quantitative approach conducted among older
people institutionalized living in nursing homes.

Methods:
Respiratory function was assessed by measuring the forced vital capacity, forced expiratory
volume in the first second, the ratio between FEV1 and FVC (FEV1/FVC), and peak expiratory flow in
percentage by means of spirometric analysis (values of the forced expiratory volume measured during
the first second of the forced breath (FEV1) and forced vital capacity (FVC)). Nutritional assessment
and anthropometry analyses were performed to evaluate under or over nutrition/weight.

Results:
There was a significant (p<0.05) and positive correlation between FEV1 and skeletal muscle
mass index, whereas fat mass index correlated significantly (p<0.01) with the FEV1/FVC index.
FEV1/FVC values were both significantly (p<0.05) associated with high body mass index and
triglyceride levels in the blood. The prevalence of individuals with ventilator restrictive pattern
(FEV1/FVC>70% with FEV1 and FVC<80%) was 27.6% and 12 individuals (21.1%) received daily
bronchodilators as part of the pharmacological treatment for respiratory disorders. Logistic regression
was performed to identify predictors of restrictive respiratory patterns. The following variables were
included in the model: age group, female gender, Charlson comorbidity index, body-mass index (BMI),
fat mass index, skeletal muscle mass index, total cholesterol, and triglycerides concentration. The model
was statistically significant (p < 0.05; R2 = 0.39), correctly classifying 70.0% of cases, with a sensitivity
of 89.3% and a specificity of 50.0%. Area under curve was 0.71 (IC95% 0.54-0.88; p=0.023).The highest
OR for the restrictive respiratory pattern was for BMI (OR=5.09) and triglycerides concentration in
blood (>150 mg/dl) (OR=5.59).

Conclusion:
The relationship between a restrictive pattern of respiratory function and fat mass deserves
future investigation to manage these parameters as a possible modifiable factor of altered respiratory
function in overweight institutionalized older individuals.
Pilot Results of a Digital Hypertension Self-management Program Among Adults With Excess Body Weight: Single-Arm Nonrandomized Trial
Authors: Wilson-Anumudu Folasade , Quan Ryan , Cerrada Christian , Juusola Jessie , Castro Sweet Cynthia , Bradner Jasik Carolyn , Turken Michael 
Published: March 2022

Background
Home-measured blood pressure (HMBP) in combination with comprehensive medication support and lifestyle change are the mainstays of evidence-based hypertension (HTN) management. To date, the precise components needed for effective HTN self-management programs have yet to be defined, and access to multicomponent targeted support for HTN management that include telemonitoring remain inaccessible and costly.

Objective
The aim of this pilot study was to evaluate the impact of a digital HTN self-management program on blood pressure (BP) control among adults with excess body weight.

Methods
A single-arm, nonrandomized trial was performed to evaluate a digital HTN self-management program that combines comprehensive lifestyle counseling with HTN education, guided HMBP, support for taking medications, and led by either a registered nurse or certified diabetes care and education specialist. A sample of 151 participants were recruited using a web-based research platform (Achievement Studies, Evidation Health Inc). The primary outcome was change in systolic BP from baseline to 3 months, and secondary outcomes included change in diastolic BP and medication adherence.

Results
Participants’ mean age was 44.0 (SD 9.3) years and mean BP was 139/85 mm Hg. At follow-up, systolic and diastolic BP decreased by 7 mm Hg (P<.001, 95% CI –9.3 to –4.7) and 4.7 mm Hg (P<.001, 95% CI –6.3 to –3.2), respectively. Participants who started with baseline BP at goal remained at goal. For participants with stage 1 HTN, systolic and diastolic BP decreased by 3.6 mm Hg (P=.09, 95% CI –7.8 to 0.6) and 2.5 mm Hg (P=.03, 95% CI –4.9 to –0.3). Systolic and diastolic BP decreased by 10.3 mm Hg (P<.001, 95% CI –13.4 to –7.1) and 6.5 mm Hg (P<.001, 95% CI –8.6 to –4.4), respectively, for participants with stage 2 HTN. Medication adherence significantly improved (P=.02).

Conclusions
This pilot study provides initial evidence that a digital HTN self-management program improves BP and medication adherence.
The Influence of Paternalistic Leadership On Individual Performance
Authors: Malik Anhar Januar , Santoso C. Budi 
Published: March 2022

Introduction/Main Objectives: Paternalistic leadership as a unique leadership behavior has received the attention of researchers from various countries. The application of effective paternalistic leadership occurs in high power-distance and collectivistic cultures. Background Problems: Most studies examine the influence of paternalistic leadership at the dimensional level. In addition, the issue in paternalistic leadership research is directed to review the presence of paternalistic leadership on members’ attitudes. Novelty: First, this study is aimed at testing the united dimensions of paternalistic leadership. Second, this study focuses on the psychological mechanisms underlying the impact of paternalistic leadership on individual tasks and contextual performance. Third, this study adopts social exchange theory and affective events theory to review the role of paternalistic leadership. Research Methods: Using a statistical test of mediating process with the approach of the causal chain. This research was carried out in the context of organizations in various sectors. Finding/Results: Firstly, paternalistic leadership is present in varied organizations. Secondly, paternalistic leadership significantly influences individual tasks and contextual performance. Moreover, the findings reveal that trust in leadership enables to explain the relationship between paternalistic leadership and individual tasks and contextual performance.
Pengaruh Model Pembelajaran Guided Inquiry Terhadap Berpikir Kritis dan Hasil Belajar Siswa di MAS PAB 2 Helvetia Deli Serdang
Authors: Pitri Pitrifujiani , Tanjung Indayana Febriani , Khairuddin Khairuddin 
Published: March 2022

This study aims to determine whether there is an effect of the guided inquiry learning model in learning biology of ecosystem material on students' critical thinking and cognitive biology learning outcomes. The research design was pretest-posttest control group design. The study population was class X MIA at MAS PAB 2 Helvetia Deli Serdang, where the sample consisted of 2 classes with simple random sampling technique. Class X MIA-1 as the experimental class using the guided inquiry learning model, while class X MIA-2 as the control class uses the conventional learning model. The data collection techniques used were observation sheets and written tests, which consisted of a pretest with 40 questions and a posttest with 40 questions. Data were analyzed using inferential statistical analysis. Based on the results of critical thinking research, for the t test it was found that t = 26.286 while t table = 2.002. The learning result, for the t test, it is found that t = 22.551 while t table = 2.002, it means that t> t table means that H0 is rejected and Ha is accepted. The conclusion from the results of this study is that there is an effect of the guided inquiry learning model on critical thinking and student learning outcomes at MAS PAB 2 Helvetia Deli Serdang.
Key words: Guided Inquiry, Critical Thinking, Learning Outcomes

Abstrak. Penelitian ini bertujuan untuk mengetahui apakah ada pengaruh model pembelajaran guided inquiry dalam pembelajaran biologi materi ekosistem terhadap berpikir kritis dan hasil belajar kognitif biologi siswa. Desain penelitian ini yaitu pretest-posttest control grup design. Populasi penelitian ini adalah kelas X MIA di MAS PAB 2 Helvetia Deli Serdang, yang mana sampelnya terdiri dari 2 kelas dengan teknik acak kelas (Simple Random Sampling). Kelas X MIA-1 sebagai kelas eksperimen yang menggunakan model pembelajaran guided inquiry, sedangkan kelas X MIA-2 sebagai kelas kontrol menggunakan model pembelajaran konvensional. Teknik pengumpulan data menggunakan lembar observasi dan tes tertulis, terdiri dari pretest posttest yang berjumlah 40 soal. Data dianalisis menggunakan analisis statistik inferensial. Berdasarkan hasil penelitian berpikir kritis, untuk uji t diperoleh bahwa thitung = 26,286 sedangkan ttabel = 2,002. Hasil belajar, untuk uji t diperoleh bahwa thitung = 22,551 sedangkan ttabel = 2,002, itu berarti bahwa thitung > ttabel maka H0 ditolak dan Ha diterima. Kesimpulan dari hasil penelitian ini yaitu ada pengaruh model pembelajaran guided inquiry terhadap berpikir kritis dan hasil belajar siswa di MAS PAB 2 Helvetia Deli Serdang.
Kata kunci: Guided Inquiry, Berpikir Kritis, Hasil Belajar
Hubungan Antara Lingkungan Belajar Dengan Kelelahan Siswa SMA Di Kota Surabaya
Authors: Darma Hadyan Adi 
Published: March 2022

Kelelahan pada siswa disebabkan oleh banyak faktor contohnya adalah lingkungan belajar yang dipilih pada siswa. Pada faktanya siswa SMA di Surabaya siswa memiliki lingkungan belajar yang kurang aktif seperti sering membolos, tidak memperhatikan saat pembelajaran, malas-malasan untuk belajar dan lain-lain maka otomatis motivasi dan semangat siswa untuk belajar kurang sehingga siswa akan mudah jenuh dan lelah untuk belajar. Peran orang tua dalam lingkungan fasilitas pada siswa juga kurang, fasilitas yang dimiliki siswa SMA di Surabaya rata-rata masih kurang. jika fasilitas sudah lengkap dan memadai maka siswa juga akan semangat dan memiliki motivasi yang tinggi untuk belajar. Penelitian ini bertujuan untuk mengetahui hubungan antara lingkungan belajar siswa dengan kelelahan siswa kelas XII SMA/sederajat tahun ajaran 2020/2021 di Kota Surabaya. Metode yang digunakan dalam penelitian ini adalah pendekatan kuantitatif dengan jenis cross sectional . Populasi dalam penelitian ini adalah siswa kelas XII SMA/sederajat di Kota Surabaya. Penentuan sampel menggunakan teknik simple random sampling. Sampel dalam penelitian ini sebanyak 212 siswa. Metode pengumpulan data dalam penelitian adalah metode angket. Hasil uji analisis statistik menggunakan Fisher’s Chi Square. Hasil penelitian menunjukkan ada hubungan antara lingkungan belajar dengan kelelahan siswa kelas XII SMA/sederajat tahun ajaran 2020/2021 di Kota Surabaya. Besarnya hubungan dilihat dari uji Fisher’s Chi Square dan terdapat hubungan positif antara variabel lingkungan belajar dengan kelelahan sebesar 0,039 dengan 0,05. Nilai p < ,sehingga Ho ditolak.Kesimpulan dari penelitian ini adalah dari 212 siswa mengalami kelelahan yang dikategorikan sedang.Pada hasil uji analis statistik menunjukkan terdapatnya hubungan antara lingkungan belajar dengan kelelahan yang dialami siswa.
Analisis Masalah Penyakit Menular Prioritas Di Provinsi Sulawesi Tengah
Authors: Rizaldi Mohamad , Wahyono Tri Yunis Miko , Suardiyasa I Made 
Published: March 2022

Provinsi Sulawesi Tengah masih menghadapi masalah penyakit endemis seperti Sistosomiasis serta KLB yang rutin terjadi menambah permasalahan penyakit menular. Penelitian ini bertujuan untuk mengidentifikasi dan menentukan masalah penyakit menular prioritas serta penyebab penyakit menular prioritas. Penelitian ini dilakukan pada bulan Desember 2020 hingga Februari 2021 di Dinas Kesehatan Provinsi Sulawesi Tengah. Penelitian ini merupakan studi deskriptif dengan pendekatan kuantitatif dan kualitatif dengan mereview profil kesehatan tahun 2015-2019 dan data terkait lainnya. Prioritas masalah menggunakan metode PAHO-Adapted-Hanlon dan analisis penyebab masalah prioritas menggunakan metode Root Cause Analysis. Hasil Identifikasi masalah penyakit menular di Provinsi Sulteng yaitu CNR TB 220/100.000 penduduk dengan CFR 3,5%. Kasus HIV sebanyak 1811 kasus dan AIDS sebanyak 913 kasus dengan CFR 7%. Prevalensi Kusta 0,83/100.000 penduduk. Cakupan penemuan kasus pneumonia balita hanya 55,3% dengan CFR 0,12%, IR diare 17,3/1000 penduduk. API Malaria sudah mencapai 0,04/1000 penduduk. Kasus GHPR 3461 kasus dengan kasus Rabies Lyssa 8 kasus. IR Filariasis 6,3/100.000 penduduk dengan CFR 2,1%. PR Sistosomiasis pada manusia 0,1% sedangkan pada keong 2,5%. Hanya 1 kasus difteri yang ditemukan, terdapat 5 kasus Rubella dan tidak ada kasus campak. AFP rate 2,17/100.000 penduduk. Dari uraian tersebut, prioritas masalah penyakit menular di Provinsi Sulawesi Tengah yaitu Tuberkulosis (skor: 35,7), Rabies (Skor: 26,2) dan Demam Berdarah Dengue (Skor:24,5). Diharapkan dapat meningkatkan angka penemuan kasus TB dan jumlah layanan TB-RO, meningkatkan jumlah rabies center dan pengetahuan masyarakat terkait rabies serta meningkatkan kesadaran masyarakat terkait PSN.