bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current Transition Practice for Primary Immunodeficiencies and Autoinflammatory Diseases in Europe: a RITA-ERN Survey
Authors: Israni Muskan , Nicholson Bethany , Mahlaoui Nizar , Obici Laura , Rossi-Semerano Linda , Lachmann Helen , Hayward Georgia , Avramovič Mojca Zajc , Guffroy Aurelien , Dalm Virgil , Rimmer Rachel , Solis Leire , Villar Carlotta , Gennery Andrew R. , Skeffington Stephanie , Nordin Julia , Warnatz Klaus , Korganow Anne-Sophie , Antón Jordi , Cattalini Marco , Amin Tania , Berg Stephan , Soler-Palacin Pere , Burns Siobhan O. , Campbell Mari ,   RITA-ERN Transition Working Group Consortium, Wouters C. , Meyts I. , van der Werff ten Bosch J. E. , Goffin L. , Ogunjimi B. , Gilliaux O. , Kelecic J. , Jelusic M. , Fingerhutová Š. , Sediva A. , Herlin T. , Seppänen Mikko R. J. , Aalto K. , Ritterbusch H. , Insalaco A. , Moschese V. , Plebani A. , Cimaz R. , Canessa C. , Dellepiane R. M. , Carrabba M. , Barzaghi F. , van Laar J. A. M. , Wulffraat N. M. , Marques L. , Carreras C. , Sánchez-Manubens J. , Alsina L. , Seoane Reula M. E. , Mendez-Echevarria A. , Gonzales-Granado L. I. , Santamaria M. , Neth O. , Ekwall O. , Brodszki O. , Hague H. , Devlin L. A. , Brogan P. , Arkwright P. D. , Riordan A. , McCann L. , McDermott E. , Faust S. N. , Carne E. 
Published: October 2022

Abstract
Background
Due to the absence of curative treatments for inborn errors of immunity (IEI), children born with IEI require long-term follow-up for disease manifestations and related complications that occur over the lifespan. Effective transition from pediatric to adult services is known to significantly improve adherence to treatment and long-term outcomes. It is currently not known what transition services are available for young people with IEI in Europe.

Objective
To understand the prevalence and practice of transition services in Europe for young people with IEI, encompassing both primary immunodeficiencies (PID) and systemic autoinflammatory disorders (AID).

Methods
A survey was generated by the European Reference Network on immunodeficiency, autoinflammatory, and autoimmune diseases Transition Working Group and electronically circulated, through professional networks, to pediatric centers across Europe looking after children with IEI.

Results
Seventy-six responses were received from 52 centers, in 45 cities across 17 different countries. All services transitioned patients to adult services, mainly to specialist PID or AID centers, typically transferring up to ten patients to adult care each year. The transition process started at a median age of 16–18 years with transfer to the adult center occurring at a median age of 18–20 years. 75% of PID and 68% of AID centers held at least one joint appointment with pediatric and adult services prior to the transfer of care. Approximately 75% of PID and AID services reported having a defined transition process, but few centers reported national disease-specific transition guidelines to refer to.

Conclusions
Transition services for children with IEI in Europe are available in many countries but lack standardized guidelines to promote best practice.
3-Point block backward differentiation formula with an off-step point for the solutions of stiff chemical reaction problems
Authors: Soomro Hira , Zainuddin Nooraini , Daud Hanita , Sunday Joshua , Jamaludin Noraini , Abdullah Abdullah , Mulono Apriyanto , Kadir Evizal Abdul 
Published: October 2022

AbstractA major challenge in simulating chemical reaction processes is integrating the stiff systems of Ordinary Differential Equations (ODEs) describing the chemical reactions due to stiffness. Thus, it would be of interest to search systematically for stiff solvers that are close to optimal for such problems. This paper presents an implicit 3-Point Block Backward Differentiation Formula with one off-step point (3POBBDF) for the solutions of first-order stiff chemical reaction problems. In deriving the method, the Lagrange polynomial was adopted as the basis function. The paper further analyses the basic properties of the 3POBBDF which include order of accuracy, consistence, zero-stability, and convergence. The stability region as well as the interval of instability of the method was also computed. To demonstrate the accuracy of the proposed approach, some famous stiff chemical reaction problems such as Robertson problem and Chemical AKZO were solved, and the results obtained were compared with those of some existing methods. The results obtained clearly show that the 3POBBDF performs better than the existing methods with which we compared our results.
Re-envisioning, Retooling, and Rebuilding Prevention Science Methods to Address Structural and Systemic Racism and Promote Health Equity
Authors: Murry Velma McBride , Bradley Cory , Cruden Gracelyn , Brown C. Hendricks , Howe George W. , Sepùlveda Martín-Josè , Beardslee William , Hannah Nanette , Warne Donald 
Published: October 2022

AbstractThe historic momentum from national conversations on the roots and current impacts of racism in the USA presents an incredible window of opportunity for prevention scientists to revisit how common theories, measurement tools, methodologies, and interventions can be radically re-envisioned, retooled, and rebuilt to dismantle racism and promote equitable health for minoritized communities. Recognizing this opportunity, the NIH-funded Prevention Science and Methodology Group (PSMG) launched a series of presentations focused on the role of Prevention Science to address racism and discrimination guided by a commitment to social justice and health equity. The current manuscript aims to advance the field of Prevention Science by summarizing key issues raised during the series’ presentations and proposing concrete research priorities and steps that hold promise for promoting health equity by addressing systemic racism. Being anti-racist is an active practice for all of us, whether we identify as methodologists, interventionists, practitioners, funders, community members, or an intersection of these identities. We implore prevention scientists and methodologists to take on these conversations with us to promote science and practice that offers every life the right to live in a just and equitable world.
The weak Gram law for Hecke $$ L $$-functions
Authors: Weishäupl Sebastian 
Published: October 2022

AbstractWe generalize a theorem by Titchmarsh about the mean value of Hardy’s $$Z$$
Z
-function at the Gram points to the Hecke $$L$$
L
-functions, which in turn implies the weak Gram law for them. Instead of proceeding analogously to Titchmarsh with an approximate functional equation we employ a different method using contour integration.
The exponential-type generating function of the Riemann zeta-function revisited
Authors: Noda Takumi 
Published: October 2022

AbstractDirichlet series associated with the Poincaré series attached to $$\mathrm{SL}(2,{{\mathbb {Z}}})$$

SL
(
2
,
Z
)

are introduced. Integral representations and transformation formulas are given, which describe the Voronoï-type summation formula for the exponential-type generating function of the Riemann zeta-function. As an application, a new proof of the Fourier series expansion of holomorphic Poincaré series is given.
Accountants in family firms—a systematic literature review
Authors: Sandgren Mattias , Uman Timur , Nordqvist Mattias 
Published: October 2022

Abstract The purpose of this article is to review the body of the literature on the role of individual accountants in the context of family firms, synthesize the findings, outline directions for future research, and to present an integrative framework that summarizes these directions. The study utilizes a systematic literature review approach and is guided by three overarching questions related to the field’s development, a reflection on current state-of-the-art research, and an outlook for the field’s future paths. The questions are answered through the mapping and analysis of 39 key articles over a 20-year period. We show central patterns in theory, data, methods, and findings. Our review reveals that the literature is scattered, and that the role of accountants is found to be context dependent. In existing research, an accountant tends to have the roles of a traditional bean counter, a decision-maker, an advisor, and a protector and mediator. Scholars also show that an accountant influences various organizational outcomes in family firms. The review further reveals that accountants can play a key role in accounting- and strategy-related decisions with impact on family firm’s survival and growth. We offer a map of the research on accountants in family firms and an integrative framework. This work does not only highlight the importance of an accountant’s role in family firms but it also allows us to identify numerous research gaps and a pathway for future research in terms of methods, theories, and models.
On the pure logic of justified belief
Authors: Schuster Daniela , Horsten Leon 
Published: October 2022

AbstractJustified belief is a core concept in epistemology and there has been an increasing interest in its logic over the last years. While many logical investigations consider justified belief as an operator, in this paper, we propose a logic for justified belief in which the relevant notion is treated as a predicate instead. Although this gives rise to the possibility of liar-like paradoxes, a predicate treatment allows for a rich and highly expressive framework, which lives up to the universal ambitions of investigating epistemological concepts. We start with a base theory for justified belief, and then systematically present putative additional axioms for justified belief. We provide an overview of (in)consistency results when the additional principles are added to the base theory, and discuss their philosophical plausibility.
Seismological footprint of an anomalous atmospheric activity registered in March 2021, in Baja California, Mexico
Authors: Flores-Estrella Hortencia , Ávila-Barrientos Lenin , Gonzalez-Huizar Hector 
Published: October 2022

AbstractOn 11 March 2021, a quite short strong signal was recorded by seismic stations of the CICESE Seismic Network, which cannot be associated with any regional or global earthquake. At the CICESE Campus and all along the city of Ensenada, in Baja California, Mexico, people reported vibration of the windows and even a short strong rumbling. Fortunately, houses and buildings did not report any damage. Due to the interaction between the atmosphere and the shallow earth surface, this anomalous atmospheric activity produced a special seismological footprint, with frequencies between 1 and 10 Hz. In this manuscript, we report on the observations of a multiparameter dataset, including seismic data along with wind velocity, wind density, temperature, humidity, atmospheric pressure, and THSW index. The atmospheric perturbation wave was strong enough to be clearly recorded by seismic stations within an area of almost 80 km and to produce some changes in the recorded meteorological parameters. The results from an FK analysis show that the atmospheric activity occurred to the south of Ensenada City and travelled to the north, as shown in the seismic records. We discuss the characteristics of the seismic signals in the frequency domain and the relation to the changes in the atmospheric parameters that could be related to this anomalous atmospheric activity.
Digoxin Induces Human Astrocyte Reaction In Vitro
Authors: Pamies David , Vujić Tatjana , Schvartz Domitille , Boccard Julien , Repond Cendrine , Nunes Carolina , Rudaz Serge , Sanchez Jean-Charles , González-Ruiz Víctor , Zurich Marie-Gabrielle 
Published: October 2022

AbstractAstrocyte reaction is a complex cellular process involving astrocytes in response to various types of CNS injury and a marker of neurotoxicity. It has been abundantly studied in rodents but relatively poorly in human cells due to limited access to the brain. Astrocytes play important roles in cerebral energy metabolism and are also key players in neuroinflammation. Astroglial metabolic and inflammatory changes have been reported with age, leading to the hypothesis that mitochondrial metabolism and inflammatory responses are interconnected. However, the relationship between energy metabolism and astrocyte reactivity in the context of neurotoxicity is not known. We hypothesized that changes in energy metabolism of astrocytes will be coupled to their activation by xenobiotics. Astrocyte reaction and associated energy metabolic changes were assessed by immunostaining, gene expression, proteomics, metabolomics, and extracellular flux analyses after 24 h of exposure of human ReN-derived astrocytes to digoxin (1–10 µM) or TNFα (30 ng/ml) used as a positive control. Strong astrocytic reaction was observed, accompanied by increased glycolysis at low concentrations of digoxin (0.1 and 0.5 µM) and after TNFα exposure, suggesting that increased glycolysis may be a common feature of reactive astrocytes, independent of the triggering molecule. In conclusion, whether astrocyte activation is triggered by cytokines or a xenobiotic, it is strongly tied to energy metabolism in human ReN-derived astrocytes. Increased glycolysis might be considered as an endpoint to detect astrocyte activation by potentially neurotoxic compounds in vitro. Finally, ReN-derived astrocytes may help to decipher mechanisms of neurotoxicity in ascertaining the ability of chemicals to directly target astrocytes.
RETRACTED ARTICLE: Silencing of long non-coding RNA TUC338 inhibits the malignant phenotype of nasopharyngeal cancer cells via modulating the miR-1226-3p/FGF2 axis
Authors: Wang Jian , Li Liping , Jiang Xue , Wang Bin , Hu Xiaodong , Liu Weiwei , Zhang Ying 
Published: October 2022

AbstractLong noncoding RNAs (lncRNAs) have been suggested as essential regulators in the cancer progression. LncRNA TUC338 was found to promote the malignancy of various cancers, however, the involvement of TUC338 in nasopharyngeal cancer (NPC) has not been well characterized. Here, our results found the significant overexpression of TUC338 in NPC tissues. Higher level of TUC338 was also observed in NPC cells. Interestingly, NPC patients harboring overexpressed TUC338 have worse prognosis. Functional study indicated that down-regulated TUC338 remarkably suppressed the NPC cell proliferation and cell migration. Notably, depletion of TUC338 significantly inhibited the in vivo tumor growth. Mechanistically, TUC338 acted as molecular sponge of miR-1226-3p and attenuated the negative regulation of miR-1226-3p on the expression of fibroblast growth factor 2 (FGF2). Down-regulation of TUC338 inhibited FGF2 expression in NPC cells and tumor tissues. Overexpression of FGF2 attenuated the suppressed NPC proliferation upon the depletion of TUC338. Our results demonstrated the novel function of TUC338/miR-1226-3p/FGF2 axis in NPC progression, suggesting the potential diagnosis and therapeutics significance of TUC338 in NPC.
Remdesivir-related cost-effectiveness and cost and resource use evidence in COVID-19: a systematic review
Authors: Murton Molly , Drane Emma , Jarrett James , Cornely Oliver A. , Soriano Alex 
Published: October 2022

Abstract
Background
The coronavirus disease 2019 (COVID-19) pandemic has been a global health emergency since December 2019, leading to millions of deaths worldwide and placing significant pressures, including economic burden, on individual patients and healthcare systems. As of February 2022, remdesivir is the only US Food and Drug Administration (FDA)-approved treatment for severe COVID-19. This systematic literature review (SLR) aimed to summarise economic evaluations, and cost and resource use (CRU) evidence related to remdesivir during the COVID-19 pandemic.

Methods
Searches of MEDLINE, Embase the International Health Technology Assessment (HTA) database, reference lists, congresses and grey literature were performed in May 2021. Articles were reviewed for relevance against pre-specified criteria by two independent reviewers and study quality was assessed using published checklists.

Results
Eight studies reported resource use and five reported costs related to remdesivir. Over time, the prescription rate of remdesivir increased and time from disease onset to remdesivir initiation decreased. Remdesivir was associated with a 6% to 21.3% decrease in bed occupancy. Cost estimates for remdesivir ranged widely, from $10 to $780 for a 10-day course. In three out of four included economic evaluations, remdesivir treatment scenarios were cost-effective, ranging from ~ 8 to ~ 23% of the willingness-to-pay threshold for the respective country.

Conclusions
Economic evidence relating to remdesivir should be interpreted with consideration of the broader clinical context, including patients’ characteristics and the timing of its administration. Nonetheless, remdesivir remains an important option for physicians in aiming to provide optimal care and relieve pressure on healthcare systems through shifting phases of the pandemic.
Fachfremdes Unterrichten und Schulleitungen: Einstellungen und Maßnahmen zur Unterstützung fachfremd tätiger Lehrkräfte
Authors: Porsch Raphaela , Gräsel Fabian 
Published: October 2022

ZusammenfassungDas Phänomen des fachfremd erteilten Unterrichts wurde vielfach in der Forschung unter der Frage nach den Auswirkungen auf Schülerleistungen und dem Umgang durch Lehrkräfte untersucht. Dagegen spielten Schulleitungen, die u. a. im Spannungsfeld von Unterrichtsversorgung, der Gewährleistung qualitätvollen Unterrichts und Personalführung stehen, in der Diskussion und empirischen Forschung bislang kaum eine Rolle. Im Beitrag wird eine Auswertung von elf Interviews mit Schulleitungen an Grundschulen und weiterführenden, nichtgymnasialen Schulen aus Deutschland vorgestellt. Die bislang schmale empirische Befundlage lässt grundsätzlich eine Defizitperspektive seitens der Schulleitungen vermuten. Die Forschungsliteratur verweist zudem auf eine Reihe von Begründungen zur Akzentuierung und Relativierung des Problems, welche sich den Bereichen Kontext, Akteur*innen und Inhalt zuordnen lassen. Die Auswertung der Interviewdaten mithilfe der inhaltlich strukturierenden qualitativen Inhaltsanalyse zeigt, dass die befragten Schulleitungen der Situation grundsätzlich kritisch gegenüberstehen, jedoch ihre Defizitperspektive im Verlauf der Interviews spezifizieren können und vorrangig relativierende Begründungen heranziehen. Ergänzend wurden in dieser explorativen Studie die tatsächlich implementierten Maßnahmen zur Unterstützung der fachfremd tätigen Lehrkräfte an den Schulen herausgearbeitet. Der Beitrag endet mit einem Ausblick und Vorschlägen für Anschlussarbeiten.
Unterrichtsqualität in den Naturwissenschaften. Eine vergleichende Gegenüberstellung von Ansätzen zwischen Fachspezifik und Generik
Authors: Heinitz Benjamin , Szogs Michael , Förtsch Christian , Korneck Friederike , Neuhaus Birgit J. , Nehring Andreas 
Published: October 2022

ZusammenfassungDie Frage danach, was einen guten naturwissenschaftlichen Unterricht ausmacht und die Frage, inwiefern Unterrichtsqualitätsmerkmale fachspezifisch oder generisch betrachtet werden müssen, sind grundlegende Fragestellungen mit denen sich die Unterrichtsqualitätsforschung beschäftigt. Inzwischen zeichnet sich in den Naturwissenschaftsdidaktiken ein breiter Konsens ab, dass die drei Basisdimensionen der Unterrichtsqualität,Klassenführung, konstruktive Unterstützungundkognitive Aktivierung,fachspezifisch ausdifferenziert und ergänzt werden müssen. Zur konkreten fachspezifischen Ausdifferenzierung und Ergänzung existieren in den Naturwissenschaftsdidaktiken jedoch unterschiedliche Ansätze. Im Rahmen dieses Beitrages wurden exemplarisch drei Ansätze zur fachspezifischen Ausdifferenzierung von Unterrichtsqualitätsmerkmalen herausgegriffen und vergleichend betrachtet, um so zu einem umfassenden Bild aus der Perspektive der Naturwissenschaften zu gelangen. Dazu wurden die drei Ansätze aus dem naturwissenschaftlichen Fachbereich hinsichtlich des Verwendungszwecks, der theoretischen Fundierung und der Operationalisierung einzelner Qualitätsmerkmale verglichen. Anschließend wurden die in einem Ansatz genutzten Qualitätsmerkmale jeweils in den beiden anderen Ansätzen verortet. Hierbei konnten fünf Kategorien herausgearbeitet werden, die für einen zukünftigen systematischen Vergleich mit weiteren Ansätzen genutzt werden können. Der Beitrag stellt somit eine Möglichkeit vor, unterschiedliche Forschungsansätze zur Unterrichtsqualität systematisch aufeinander zu beziehen, um so ein umfassendes Bild der Unterrichtsqualität zu erhalten.
Accept it or forget it: mandatory digital learning and technology acceptance in higher education
Authors: Lehmann Thomas , Blumschein Patrick , Seel Norbert M. 
Published: October 2022

AbstractIn early 2020, the COVID-19 pandemic led to a rapid shift to emergency remote teaching and mandatory digital learning in higher education. This study tested an extended causal model built on the Unified Theory of Acceptance and Use of Technology (UTAUT) under the restrictions on higher education stemming from the pandemic. Data collected from a survey among 485 students were analyzed using structural equation modeling. Confirmatory factor analyses were performed to examine the construct validity of the measurement model using polychoric correlations. Path analysis was used to test the causal model. The results indicate a psychologically sound baseline model with nine latent variables that affect students’ behavioral intention to accept and continue using technology for learning. However, the model is only partially in line with the proposed causal model based on UTAUT. The implications of these results are discussed in terms of technology acceptance and use in higher education, both under the restrictions leading to mandatory digital learning and in future.
Das digitale VHS-Angebot im ersten Lockdown der Corona-Pandemie. Analysen zu Veranstaltungsformaten und Programmstrukturen an Volkshochschulen
Authors: Widany Sarah , Reichart Elisabeth , Echarti Nicolas , Hoenig Kerstin 
Published: October 2022

ZusammenfassungDer Beitrag untersucht auf der Grundlage von Leistungsdaten der Volkshochschul-Statistik und einer Sonderbefragung der Volkshochschulen (VHS), wie sich während des ersten Lockdowns im Pandemiejahr 2020 die Programmvielfalt des Angebots verändert hat. Besonderes Augenmerk liegt auf der Programmstruktur, definiert als die Anteile der jeweiligen inhaltlichen Programmbereiche am Gesamtprogramm. Die Analysen zeigen, dass das Veranstaltungsangebot der VHS während des ersten Lockdowns deutlich zurückgegangen ist. Dabei gewannen Einzelveranstaltungen gegenüber Kursen im Lockdown an Bedeutung. Da sich die Umsetzung von digitalen Veranstaltungen zwischen den Programmbereichen stark unterschied, zeigt sich in der Programmstruktur eine deutliche Verschiebung.
Why pay for sustainable housing? Decomposing the green premium of the residential property market in the Canton of Zurich, Switzerland
Authors: Kempf Constantin , Syz Juerg 
Published: October 2022

AbstractVarious studies have shown that green buildings trade at a premium, with estimates of it ranging widely from low single-digits up to 26% for sales values and up to 21% for rents. There is, however, little quantified evidence of why people are willing to pay more for sustainable housing. We investigate the green premium for MINERGIE-certified residential properties in the Canton and City of Zurich, which have among the highest densities of certified green buildings worldwide. Using a comprehensive data set of 17,743 condominiums for sale and 50,075 apartments for rent, we show that the premium can be decomposed and associated with various benefits for owners and tenants. The overall green premia in the canton amount to 2.45% and in the city to 4.91%. From these total premia, 6% (city: insignificant) are attributed to energy savings, 71% (city: 70%) to increased comfort, and 23% (city: 33%) to making the building future proof against regulators and market participants.