bluuebunny/crossref_metadata_2025_split huggingface dataset:
Дослідження впливу тривалості сайклінг-процесу на коефіцієнт конденсатовилучення виснажених газоконденсатних родовищ
Authors: Matkivskyi S. V. 
Published: May 2022

Для підвищення ефективності розробки газоконденсатних родовищ зі значними запасами ретроградного конденсату проведено дослідження з використанням інструментів гідродинамічного моделювання на основі цифрової тривимірної моделі. Метою досліджень є оптимізація технології підтримання пластового тиску з використанням сухого газу. Дослідження проведено для різної тривалості періоду нагнітання сухого газу в газоконденсатний поклад (12, 24, 36, 48 та 60 місяців). За результатами проведених досліджень встановлено, що завдяки впровадженню технології нагнітання сухого газу забезпечується підтримання пластового тиску на значно вищому рівні, порівнюючи з розробкою на режимі виснаження пластової енергії. Завдяки цьому сповільнюються процеси ретроградної конденсації рідких вуглеводнів у пласті, а також стабілізуються технологічні режими експлуатації видобувних свердловин. За результатами аналізу технологічних показників розробки газоконденсатного покладу встановлено, що в разі впровадження технології підтримання пластового тиску збільшується накопичений видобуток конденсату. Згідно з результатами проведених розрахунків накопичений видобуток конденсату залежно від тривалості періоду нагнітання сухого газу становить: 12 місяців – 349,7 тис. м³; 24 місяці – 366,7 тис. м³; 36 місяців – 377,4 тис. м³; 48 місяців – 383,6 тис. м³; 60 місяців – 387,6 тис. м³. Результати моделювання засвідчують: що чим більша тривалість періоду нагнітання сухого газу, то більший накопичений видобуток конденсату. На основі статистичного аналізу розрахункових даних встановлено оптимальне значення тривалості періоду нагнітання сухого газу в газоконденсатний поклад, яке становить 34,3 місяця. Кінцевий коефіцієнт вилучення конденсату для наведеного оптимального значення тривалості періоду нагнітання сухого газу зростає на 6,06 %, порівнюючи з розробкою на виснаження.
EVALUATION OF THE EFFICIENCY OF ALPHA-LIPOIC ACID AND IPIDACRINE HYDROCHLORIDE FOR THE PREVENTION OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY ACCORDING TO THE TOTAL NEUROPATHY SCORE
Authors: Holotiuk I.S. , Kryzhanivska A.Ye. , Holotiuk S.I. , Maliborska S.V. , Holotiuk V.V. 
Published: May 2022

Aim: To evaluate the efficacy of combination of alpha-lipoic acid and acetylcholinesterase inhibitor (ipidacrine hydrochloride) to prevent the development and improve the course of paclitaxel-induced peripheral neuropathy (PIPN) in patients with breast cancer according to the Total Neuropathy Score. Materials and Methods: 32 patients with breast cancer T1-4N0-3M0 received six cycles of polychemotherapy according to the AT scheme (paclitaxel, doxorubicin) or ET scheme (paclitaxel, epirubicin). Patients were randomized into two groups — without (group I) or with (group II) medication for prevention of neuropathy. A comprehensive neurological examination of patients was performed according to all ten parameters of the Total Neuropathy Score before chemotherapy, and after third and sixth cycles of chemotherapy. Each parameter was evaluated from 0 (no deficit) to 4 (no function/the most severe deficit). The scores obtained from the scale were summarized to obtain a total score from 0 to 40. Results: The use of alpha-lipoic acid in combination with an acetylcholinesterase inhibitor (ipidacrine hydrochloride) significantly reduces the symptoms and severity of PIPN. The manifestations of PIPN in patients of the control group were significantly more severe compared to the group in which the study drugs were used. The average severity of neuropathy after 3 and 6 cycles was 1.75 and 2.62 in group I, and 1.12 and 1.62 — in group II, respectively (improvement by 15.75% (p < 0.05) and 25.00% (p < 0.001) after 3 and 6 cycles). Conclusions: Proposed combination of alpha-lipoic acid and ipidacrine hydrochloride led to a statistically significant reduction in the severity of PIPN, and thus to improvement of the functional capacity and quality of life of patients.
DIFFERENTIAL EXPRESSION PATTERN OF AIP, UCKL1, AND PKN1 GENES IN PROSTATE CANCER PATIENTS
Authors: Kovalevska L. , Zadvornyj T. , Lukianova N. , Kashuba E. 
Published: May 2022

Background: The evolution of research on the therapy of prostate cancer (PC) depends on a study of molecules that are involved in the progression of this disease. Nevertheless, there is a need for additional biomarkers that would help to refine the molecular profile of PC and propose the personalized therapeutic approach. Aim: To study differential expression patterns of the AIP, UCKL1, and PKN1 genes in blood sera and tumor tissue of patients with PC with different Gleason scores. Materials and Methods: The total extracellular RNA was isolated from blood sera of 44 PC patients and 4 healthy donors. cDNAs were synthesized and quantitative polymerase chain reaction (qPCR) was performed. Immunohistochemical study of the UCKL, AIP and PKN1 proteins was performed on deparaffinized sections of tumors. The study was supplemented by a bioinformatic analysis of the publicly available databases. Results: The UCKL1, AIP, PKN1 genes were overexpressed at the mRNA level in blood sera of PC patients, compared to healthy donors. Extracellular mRNA levels of AIP and UCKL-1 were 100-1000-fold increased in all PC samples compared to the healthy donors but without significant inequality between the groups of PC cases differing by the Gleason score. The highest levels were detected in the samples from PC patients with the Gleason score > 9. The PKN1 expression was higher in PC patients compared with healthy donors but without significant difference between the groups. Conclusions: From the three chosen genes, AIP and UCKL1 showed similar pattern of expression assessed either by extracellular mRNA levels in patient sera or the protein in PC tissues. AIP was up to 1000-fold increased in all PC samples, compared to the healthy donors, with the highest levels in PC cases with Gleason score > 9. Expression levels of the AIP and UCKL1 genes in the PC patient sera may be used as an additional criterion for prognosis of tumor progression.
Penggelapan Uang Titipan Pembayaran Pajak Bumi Bangunan oleh Notaris/PPAT dalam Perspektif Tindak Pidana Korupsi
Authors: Utami Putri Resa , Effendy Mohammad , Mispansyah Mispansyah 
Published: May 2022

Pajak merupakan salah satu komponen penting dalam pembangunan di Indonesia lantaran sektor pajak di Indonesia merupakan sumber pendapatan terbesar bagi negara. Salah satu asal potensi pajak yaitu Pajak Bumi dan Bangunan (PBB). Terhadap pembelian atas tanah maka terdapat pajak yang wajib dibayarkan oleh para pihak, penjual tanah pada hal ini akan dikenakan pajak penghasilan (PPh) & Pajak Bumi Bangunan (PBB) sedangkan pembeli akan dikenakan Bea Perolehan Hak Atas Tanah (BPHTB. Terhadap pembayaran PBB, Notaris/PPAT memiliki peran yang penting. Notaris/PPAT dapat aktif melaksanakan kewajiban pajak dari wajib pajak, yaitu wajib pajak dapat menitipkan pembayaran PBB pada Notaris/PPAT. Namun dalam praktiknya terdapat transaksi jual beli tanah dan/atau bangunan di mana pembayaran PBB-nya dititipkan oleh penjual tanah dan/atau bangunan kepada PPAT. Dalam kenyataannya, PPAT yang telah menerima penitipan pembayaran PBB tersebut tidak pernah melakukan pembayaran PBB ke Negara. Tujuan Penelitian ini untuk mengetahui mengenai uang pajak bumi dan bangunan dapat di kategorikan keuangan negara apabila digelapkan dan untuk mengetahui mengenai pertanggungjawaban pidana atas penggelapan uang pembayaran pajak bumi dan bangunan yang dilakukan oleh Notaris/PPAT. Metode penelitian hukum ini merupakan penelitian hukum normatif. Pendekatan dalam penelitian ini adalah pendekatan kasus, pendekatan perundang-undangan dan pendekatan konseptual. Hasil penelitian ini menyatakan bahwa uang yang digelapkan oleh Notaris/PPAT tersebut bisa dikategorikan keuangan negara apabila memenuhi unsur pemalsuan, di antaranya pemalsuan dokumen dan pemalsuan bukti validasi pembayaran Pajak Bumi dan Bangunan. Pertanggungjawaban Notaris/PPAT tersebut juga dikenakan Pasal 8 Undang-Undang Nomor 20 Tahun 2001 Tentang Perubahan Atas Undang-Undang Nomor 31 Tahun 1999 tentang Pemberantasan Tindak Pidana Korupsi, terutama bagi mereka yang menjalankan jabatan umum, yaitu pidana minimal 3 (tiga) tahun dan maksimal lima belas tahun penjara serta pidana denda paling sedikit Rp. 150.000.000 (seratus lima puluh juta rupiah) dan paling banyak Rp. 750.000.000 (tujuh ratus lima puluh juta rupiah).
Control de inventario y su efecto en la rentabilidad de Sociedad Civil de Hecho Denominado Grupo Uscocovich, 2020
Authors: Macías-Chila Gema , Zambrano-Intriago María 
Published: May 2022

El presente trabajo analiza el efecto del control de inventarios de acuerdo a sus políticas de devolución y su rentabilidad en Sociedad Civil de Hecho Denominado Grupo Uscocovich durante el año 2020, el cual se dedica a la distribución de productos farmacéuticos.
El diseño que se empleó fue no experimental, transversal de tipo descriptivo. Se aplicó métodos de análisis-sintético e inductivo-deductivo, además de las técnicas de la entrevista y la observación en las que se tomaron como instrumentos la guía de entrevistas y el check list. La población objeto de estudio fue de 14 personas y 144 proveedores tomados al alzar de acuerdo a las políticas de devolución y el análisis de la información se procesó en Excel.
Los resultados obtenidos determinaron que la empresa debe mejorar su gestión en cuanto a la rotación del inventario considerando las fechas de caducidad y su rotación para minimizar pérdidas, este control mejoraría el margen de rentabilidad y a la toma decisiones al momento de adquirir determinados productos.
Palabras clave: inventario, control, rentabilidad, devolución.
Pengaruh Pemberian Vitamin dan Lysin pada Pakan terhadap Gonad Lobster Air Tawar Capit Merah (Cherax quadricarinatus)
Authors: Agusrinal Agusrinal , Tolanamy Emand Syapriawan , Septiantoro Ryan 
Published: May 2022

ABSTRAKKeberhasilan budidaya lobster air tawar (LAT) sangat dipengaruhi oleh ketersediaan benih yang berkualitas dan pakan. Nutrisi mempunyai peran substansial dalam proses reproduksi. Lobster membutuhkan nutrisi pada pakan dalam bentuk energi dan asamamino esensial yang cukup, asam lemak essensial, spesifik vitamin dan mineral sehingga bisa memacu pertumbuhannya. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan pertumbuhan pada gonad dan hepatopankreas lobster air tawar yang diberi makan dengan pakan yang mengandung vitamin dan lysin. Penelitian ini dilakukan dengan menggunakan indukan LAT sebanyak 12 ekor jantan dan 36 ekor betina yang dipelihara pada kolam berukuran 200 cm x 300 cm x 30 cm dan diberi pakan dengan pakan udang komersial. Vitamin yang digunakan yaitu Vitamin C dan E sedangkan lysin yang digunakan yaitu L-lysine HCL. LAT dipelihara dengan 4 perlakuan yakni Perlakuan A (kontrol, pakan komersial tanpa penambahan apapun), Perlakuan B (pakan komersial ditambah dengan 500 mg lysin/kg pakan), Perlakuan C ( pakan komersial ditambah dengan 500 mg vitamin/kg pakan) dan Perlakuan D ( pakan komersial ditambah dengan 250 mg lysin dan 250 mg vitamin/kg pakan ). Hasil penelitian menunjukkan bahwa nilai GSI tertinggi pada perlakuan D berkisar antara 2,144285 – 4,405363 dan yang terendah pada perlakuan C berkisar antara 0,86478 – 2,397525. Nilai HSI tertinggi pada Perlakuan D berkisar antara 5,67044696 – 6,8977591 dan yang terendah pada perlakuan C yaitu berkisar antara 2,96450151 – 3,05737542. Hal ini mengindikasikan bahwa pemberian 250 mg vitamin dan 250 mg lysin pada pakan dapat mempercepat kematangan gonad LAT secara optimal sehingga bisa meningkatkan produktivitas budidaya LAT capit merah.Kata Kunci: gonad; lobster air tawar capit merah; lysin; vitamin
PENGARUH SUBSTITUSI TEPUNG MIKROALGA Chlorella vulgaris PADA PAKAN BUATAN TERHADAP PERTUMBUHAN KEPITING BAKAU (Scylla serrata)
Authors: Yusran Yusran , Iba Wa , Abidin La Ode Baytul , Hamzah Muhaimin , Kurnia Agus 
Published: May 2022

ABSTRAKPenelitian ini bertujuan untuk mengetahui pertumbuhan, kelangsungan hidup, efisiensi pakan dan retensi protein kepiting bakau (Scylla serrata) yang diberi pakan komersial dengan substitusi tepung mikroalga C. vulgaris (TMCv). Penelitian ini menggunakan 5 perlakuan yaitu substitusi pakan komersil dengan 0, 25, 50, 75, dan 100% TMCv. Kepiting bakau dengan berat awal berkisar pada 70-90 gram dipelihara selama 45 hari dengan kepadatan 1 ekor/ruang. Parameter yang diukur adalah tingkat kelangsungan hidup, laju pertumbuhan spesifik, pertumbuhan mutlak, rasio konversi pakan, efisiensi pakan, dan kualitas air. Tingkat kelangsungan hidup kepiting bakau adalah 100% pada semua perlakuan. Laju pertumbuhan spesifik, pertumbuhan mutlak, rasio konversi pakan, dan efisiensi pakan kepiting bakau menunjukkan hasil yang lebih baik pada perlakuan pakan 100% TMCv dibandingkan dengan pakan 0, 25, 50, 75% TMCv. Perlakuan 0% TMCv atau pakan komersil 100% mendapatkan nilai terendah dari seluruh parameter yang diamati. Penelitian ini mengindikasikan bahwa pemberian pakan 100% TMCv sangat efisien dibandingkan dengan menggunakan pakan komersial atau pakan substitusi TMCv untuk pertumbuhan kepiting bakau. Kata kunci: Chlorella vulgaris, kepiting bakau, pertumbuhan
Ikan Kepait Dari Selatan Pulau Bangka Sebagai Kandidat Spesies Baru Berdasarkan Meristik Dan Gen Sitokrom b
Authors: Kurniawan Ardiansyah , Syarif Ahmad Fahrul 
Published: May 2022

AbstrakIkan Kepait merupakan salah satu ikhtiofauna yang ditemukan keberadaannya di Pulau Bangka. Ikan lokal yang juga ditemukan di selatan Pulau Bangka ini memerlukan diidentifikasi secara morfologi dan molekuler untuk memastikan taksonominya. Eksplorasi sampel ikan dilakukan di Desa Bencah, Kecamatan Air Gegas, Kabupaten Bangka Selatan. Pengamatan karakter morfologi meliputi ciri fisik dan meristik, sementara identifikasi molekuler menggunakan gen sitokrom b. Morfologi ikan menunjukkan kemiripan dengan Osteochilus spilurus pada terdapatnya bulatan besar pada pangkal ekor, linealateralis pada 29 -31 sisik, predorsal scale pada sisik ke 8-9, formula sirip dorsal D iii.12-13 dan sirip anal A.6. Namun terdapat perbedaan pada membran sirip berwarna kemerahan dan jumlah sisik linealateralis. Karakterisasi DNA gen sitokrom b menghasilkan nukleotida dengan panjang 1136 bp menunjukkan perbedaan cabang dengan Osteochilus spilurus dari pulau yang sama pada konstruksi pohon filogenetik dengan jarak genetik lebih dari 20%. Kondisi ini memungkinkan sampel ikan dari selatan Pulau Bangka ini menjadi kandidat spesies baru dalam genus Osteochilus.Kata kunci : Osteochilus spilurus, spesies baru, Bangka Selatan, Sitokrom b.
Clinical Characteristics and Long-Term Outcomes of MINOCA Accompanied by Active Cancer: A Retrospective Insight Into a Cardio-Oncology Center Registry
Authors: Stepien Konrad , Nowak Karol , Szlosarczyk Barbara , Nessler Jadwiga , Zalewski Jaroslaw 
Published: May 2022

BackgroundClinical characteristics and long-term outcomes of patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) and cancer are insufficiently elucidated.ObjectivesWe sought to characterize these patients hospitalized in a tertiary cardio-oncology center and to find the potential determinants affecting their long-term mortality.MethodsMINOCA was diagnosed in 72 of the 1,011 patients with consecutive myocardial infarction who underwent coronary angiography. Mortality rates and their determinants were analyzed within a median follow-up of 69.2 (37.8–79.9) months.ResultsActive cancer was identified in 21 (29.2%) of patients with MINOCA and in 113 (12.0%) patients with myocardial infarction and obstructive coronary artery disease (MI-CAD) (p &lt; 0.001). MINOCA patients with cancer were characterized by a higher incidence of anemia (47.6 vs. 21.6%, p = 0.03) and more frequently Takotsubo syndrome (19.1 vs. 2.0%, p = 0.01) than in non-cancer MINOCA. The troponin T/hemoglobin ratio was higher in both cancer MINOCA and MI-CAD groups when compared with their respective non-cancer patients (both p &lt; 0.05). The age and sex-standardized mortality rates were significantly higher in cancer MINOCA (26.7%/year) when compared with non-cancer MINOCA (2.3%/year, p = 0.002) and in cancer MI-CAD (25.0%/year) vs. non-cancer MI-CAD (3.7%/year, p &lt; 0.001). Active cancer (HR 3.12, 95% CI 2.41–4.04) was independently associated with higher long-term mortality, while higher hemoglobin levels (HR 0.93, 95% CI 0.88–0.99, per g/dl) and a MINOCA diagnosis (HR 0.69, 95% CI 0.47–0.97) improved long-term survival.ConclusionPatients with MINOCA were comorbid with cancer more frequently than MI-CAD. In turn, an active malignancy was associated with an unfavorable long-term survival both in MI-CAD population and in patients with MINOCA.
Podocan and Adverse Clinical Outcome in Patients Admitted With Suspected Acute Coronary Syndromes
Authors: Andersen Thomas , Ueland Thor , Aukrust Pål , Nilsen Dennis W. , Grundt Heidi , Staines Harry , Kontny Frederic 
Published: May 2022

BackgroundMarkers of bone and extracellular matrix (ECM) remodeling may be associated with adverse outcomes in atherosclerotic cardiovascular disease. Podocan is a newly discovered ECM glycoprotein, previously not studied in a chest pain population. We wanted to study the association between Podocan levels on admission and the risk of adverse outcomes in a chest pain population with suspected acute coronary syndromes.MethodsA total of 815 patients from the Risk markers in Acute Coronary Syndrome (RACS) trial with suspected coronary chest pain were followed for 7 years. Blood samples were taken immediately after inclusion and stored in the biobank. Associations between Podocan and endpoints were assessed with Cox proportional hazards analyses.ResultsThe median admission level of Podocan was 0.674 ng/ml (0.566–0.908 ng/ml). No significant association was found between Podocan quartile levels and all-cause death, neither at 1 year nor 2- or 7-years follow-up (p&gt; 0.05 for all). Furthermore, no significant association could be shown between Podocan and cardiac death, myocardial infarction (MI), stroke, or the composites of all-cause death/MI/stroke or cardiac death/MI/stroke (p&gt; 0.05 for all). Similarly, in a subgroup of patients with Troponin T-positive (n= 432) there was no significant association between Podocan and any of the outcome measures (p&gt; 0.05 for all endpoints and points in time).ConclusionPodocan, a novel ECM biomarker, is not associated with all-cause mortality or other major cardiovascular adverse events in patients admitted with acute chest pain suspected to be of coronary origin.Clinical Trials.gov Identifier:NCT00521976.
Contrast-Enhanced Ultrasonography Enables the Detection of a Cold Pressor Test-Induced Increase in Renal Microcirculation in Healthy Participants
Authors: Hendriks-Balk Mariëlle C. , Damianaki Aikaterini , Polychronopoulou Erietta , Brito Wendy , Pruijm Menno , Wuerzner Gregoire 
Published: May 2022

BackgroundRenal microcirculation is essential for regulation of the glomerular filtration rate, the reabsorption of salt and water from the interstitium, and hence the blood pressure. Renal ultrasonography coupled to Doppler analysis and contrast-enhanced ultrasound enables the study of renal perfusion. So far, physiologic interventions have rarely been performed to assess the renal perfusion. The objective of our study was to measure the renal perfusion in response to a cold pressor test (CPT).MethodsHealthy adult participants were exposed to a 2 min CPT or a sham exposure (body temperature). Systemic hemodynamics, renal resistive index (RRI) and renal perfusion index (PI) were measured before and during the CPT or the sham exposure. Renal responses were compared using a paired Student's t-test or Wilcoxon signed rank test. Pearson correlation test was used to test association of variables of interest.ResultsForty-one normotensive participants (21 women) were included in the study. Mean blood pressure and heart rate both increased with the CPT. The RRI decreased from 0.60 ± 0.05 arbitrary units (AU) to 0.58 ± 0.05 AU (p &lt; 0.05) and the PI increased from 2,074 AU (1,358–3,346) to 3,800 AU (2,118–6,399) (p &lt; 0.05) (+66% (24–106%)). Compared to the sham exposure, the increase in PI with the CPT was more marked. There was a negative association between the increase in heart rate and mean blood pressure with the RRI (r: −0.550, p = 0.002 and r: −0.395, P = 0.016), respectively.ConclusionDoppler Ultrasound and CEUS enable the detection of physiological changes within the macro- and microvascular renal circulation. The CPT decreases the RRI and increases the PI. Whether these changes are present in pathological states such as diabetes or hypertension will need additional studies.
The Association Between Metabolic Syndrome and Prostate Cancer Risk: A Large-Scale Investigation and Study of Chinese
Authors: Gao Xiaoshuai , Li Ruicen , Jin Tao , Tang Huairong 
Published: May 2022

BackgroundTo investigate the association between metabolic syndrome (MetS) and its components and prostate cancer (PCa).MethodsThis study enrolled 482 943 consecutive men who underwent routine health checkups at the Health Management Center of West China Hospital Between 2010 and 2017. For patients with elevated prostate-specific antigen (PSA) levels or color Doppler ultrasound indicating abnormal prostates, we recommended prostate puncture and follow-up. We used the chi-square test and independent t-test for categorical variables and continuous variables, respectively. We used logistic regression analysis to evaluate the effects of MetS and its components on prostate cancer risk.ResultsWe found that the incidence of PCa in Chinese men over 40 years of age was 0.1%. Among the 85882 participants, 31.5% (27016/85882) of the patients were diagnosed with MetS. PCa was associated with older age, higher PSA levels, lighter weight and shorter height, hypertension, elevated fasting blood glucose (FBG) and HDL cholesterol level, lower triglycerides. After excluded the interference of other factors in multivariate logistic analysis, we found that MetS, hypertension, hyperlipidemia, hyperglycemia, and obesity were not related to the risk of PCa. High age and PSA levels were risk factors for prostate cancer.ConclusionsHigh age and PSA levels were risk factors for prostate cancer. MetS, hypertension, hyperlipidemia, hyperglycemia, and obesity were not related to the risk of PCa.