bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using Electronic Dental Records to Assess Osteoradionecrosis Risk in Irradiated Head and Neck Cancer
Authors: Saenthaveesuk P. , Kiat-amnuay S. , Walji M.F. 
Published: April 2022

Objective: Over the last 2 decades, investigations have demonstrated a decreased trend in the likelihood of osteoradionecrosis of the jaw (ORNJ) after extraction. The aim of this study was to explore the potential risk factors for ORNJ in irradiated head and neck cancer by using patients’ electronic dental records (EDRs). Methods: Patients diagnosed with head and neck cancer who had irradiation between January 2010 and December 2020 were included in this retrospective cohort analysis. Patient charts showing evidence of “head and neck cancer,” “oral cancer,” “radiotherapy,” “radiation,” and “oral complication” were identified by an informatics analyst querying the EDR. Subsequently, the charts were manually reviewed, and data quality was assessed on 3 dimensions: completeness, accuracy, and consistency. The patient, tumor, systemic condition/drug, oral condition, treatment/trauma, and radiation were all categorized as potential risk factors. Results: A total of 359 patients were included. With the exception of radiation-related factors, we found that the data quality was generally sufficient to support the research. Multivariate logistic regression analysis demonstrated that the following factors were significant in predicting the occurrence of ORNJ development in irradiated head and neck cancer: smoking (odds ratio [OR], 9.0; 95% CI, 1.9 to 43.0; P = 0.006), steroid use (OR, 6.4; 95% CI, 1.3 to 30.8; P = 0.021), oral health status (OR, 23.7; 95% CI, 2.7 to 211.0; P = 0.005), and postirradiation extraction (OR, 3.8; 95% CI, 1.0 to 14.4; P = 0.050). Conclusions: A 10-y retrospective analysis of data from an EDR revealed that smoking, steroid use, poor oral status, and postirradiation extraction are all factors linked to an increased risk of developing ORNJ. The quality of EDR data may be systematically assessed by determining the completeness, accuracy, and consistency of the underlying data. Radiation-related factors in particular were poorly documented, highlighting the need for collecting or incorporating this information into the EDR. Knowledge Transfer Statement: EDRs can be used to identify risk factors for developing ORNJ in irradiated head and neck cancer and can help clinicians with selecting treatments by incorporating risk and complication considerations.
Defenestrated endothelium delays liver-directed gene transfer in hemophilia A mice
Authors: Kaminski Tomasz W. , Ju Eun-Mi , Gudapati Shweta , Vats Ravi , Arshad Sanya , Dubey Rikesh K. , Katoch Omika , Tutuncuoglu Egemen , Frank Jonathan , Brzoska Tomasz , Stolz Donna B. , Watkins Simon C. , Chan Stephen Y. , Ragni Margaret V. , Novelli Enrico M. , Sundd Prithu , Pradhan-Sundd Tirthadipa 
Published: April 2022

Abstract
Hemophilia A is an inherited bleeding disorder caused by defective or deficient coagulation factor VIII (FVIII) activity. Until recently, the only treatment for prevention of bleeding involved IV administration of FVIII. Gene therapy with adeno-associated vectors (AAVs) has shown some efficacy in patients with hemophilia A. However, limitations persist due to AAV-induced cellular stress, immunogenicity, and reduced durability of gene expression. Herein, we examined the efficacy of liver-directed gene transfer in FVIII knock-out mice by AAV8-GFP. Surprisingly, compared with control mice, FVIII knockout (F8TKO) mice showed significant delay in AAV8-GFP transfer in the liver. We found that the delay in liver-directed gene transfer in F8TKO mice was associated with absence of liver sinusoidal endothelial cell (LSEC) fenestration, which led to aberrant expression of several sinusoidal endothelial proteins, causing increased capillarization and decreased permeability of LSECs. This is the first study to link impaired liver-directed gene transfer to liver-endothelium maladaptive structural changes associated with FVIII deficiency in mice.
A predictive model for bone marrow disease in cytopenia based on noninvasive procedures
Authors: Træden Dicte , Tulstrup Morten , Cowland Jack Bernard , Sjö Lene Dissing , Bøgsted Martin , Grønbæk Kirsten , Andersen Mette Klarskov , Hansen Jakob Werner 
Published: April 2022

Abstract
Bone marrow specimens are the core of the diagnostic workup of patients with cytopenia. To explore whether next-generation sequencing (NGS) could be used to rule out malignancy without bone marrow specimens, we incorporated NGS in a model to predict presence of disease in the bone marrow of patients with unexplained cytopenia. We analyzed the occurrence of mutations in 508 patients with cytopenia, referred for primary workup of a suspected hematologic malignancy from 2015 to 2020. We divided patients into a discovery (n = 340) and validation (n = 168) cohort. Targeted sequencing, bone marrow biopsy, and complete blood count were performed in all patients. Mutations were identified in 267 (53%) and abnormal bone marrow morphology in 188 (37%) patients. Patients with isolated neutropenia had the lowest frequency of both mutations (21%) and abnormal bone marrow morphology (5%). The median number of mutations per patient was 2 in patients with abnormal bone marrow morphology compared with 0 in patients with a nondiagnostic bone marrow morphology (P &lt; .001). In a multivariable logistic regression, mutations in TET2, SF3B1, U2AF1, TP53, and RUNX1 were significantly associated with abnormal bone marrow morphology. In the validation cohort, a model combining mutational status and clinical data identified 34 patients (20%) without abnormal bone marrow morphology with a sensitivity of 100% (95% confidence interval: 93%-100%). Overall, we show that NGS combined with clinical data can predict the presence of abnormal bone marrow morphology in patients with unexplained cytopenia and thus can be used to assess the need of a bone marrow biopsy.
Serpentinite dehydration at low pressures
Authors: Kempf Elias D. , Hermann Jörg , Connolly James A. D. 
Published: April 2022

AbstractPetrographic observations combined with mineral compositional analyses constrain the phase relations of prograde metamorphosed serpentinites in the Bergell contact aureole (Italy). In a 1500 m profile perpendicular to the north-eastern edge of the Bergell intrusion, seven dehydration reactions ran to completion. Three previously undocumented reactions have been identified within 70 m of the intrusive contact: olivine + anthophyllite = orthopyroxene + H2O, tremolite + Cr–Al-spinel = olivine + Mg-hornblende + H2O and chlorite = olivine + orthopyroxene + Cr-Al-spinel + H2O. Petrological analysis indicates that these reactions occur over a narrow range of pressure and temperature, 300 ± 30 MPa and 720 ± 10 °C respectively. Computed phase diagram sections reproduce the observed mineral parageneses with one notable exception. Due to the underestimation of aluminium and sodium contents in Ca-amphibole models, plagioclase is predicted above 700 °C instead of Mg-hornblende. In comparison with natural grains, the aluminium content of computed chlorite compositions is overestimated for low grade parageneses while it is underestimated near the upper thermal stability limit of chlorite. In the computed sections, Fe partitioning relative to Mg between olivine and other silicates, suggests a clear preference for Fe in olivine, that therefore shows lower Mg#s. In contrast, microprobe analyses of natural mineral pairs indicate that orthopyroxene, Mg-hornblende and anthophyllite have lower Mg#s than equilibrium olivine. The inferred thermal profile of the metamorphic aureole is not consistent with simple heat conduction models and indicates a contact temperature of ~ 800 °C, which is 120–230 °C higher than previously estimated. Petrography also reveals extensive retrograde overprint of the prograde parageneses within 200 m of the contact. Retrogression is related to metamorphic fluids that were released by dehydration reactions during contact metamorphism and magmatic fluids expelled from the tonalite intrusion. The thermal gradient between the intrusion and the country rocks induced hydrothermal circulation of these fluids throughout the contact aureole, which beyond peak metamorphic conditions caused retrograde overprint of the prograde parageneses. The proposed phase relations for low and high pressures, and in particular, the transition from tremolite to Mg-hornblende, provides a complete representation of hydration and dehydration processes in serpentinites in subduction zones, along deep oceanic transform faults, and at passive continental margins. The latter has new implications, specifically for subduction initiation.
Dynamics of phytoplankton community in scallop farming waters of the Bohai Sea and North Yellow Sea in China
Authors: Kong Ning , Liu Zhaoqun , Yu Zichao , Fu Qiang , Li Huan , Zhang Yukun , Fang Xiao , Zhang Fuchong , Liu Chao , Wang Lingling , Song Linsheng 
Published: April 2022

Abstract
Background
As the major suppliers of food for higher consumers, phytoplankton are closely related to the yield, nutritional ingredients and even toxin contents of mariculture animals, potentially influencing the human health when they are consumed. With the increase of shellfish culture density, phytoplankton in the coastal waters have been excessively consumed in recent years, and the nutrients they depend on are becoming more and more limited, which severely restrict the shellfish mariculture and threaten the coastal ecosystems.

Results
In the present study, nutrient concentrations, phytoplankton assemblages and scallop growth status were investigated in the main bay scallop farming waters of the Bohai Sea (Qinhuangdao site) and North Yellow Sea (Zhuanghe site) in 2018. Both phosphate and silicate limitations were observed at the two sites, with the major determinant of phytoplankton assemblages being silicate in Qinhuangdao and phosphate in Zhuanghe, respectively. The phytoplankton assemblages at the two sites displayed different community structures and succession patterns. The phytoplankton community was dominated by dinoflagellates and diatoms in Qinhuangdao, while dinoflagellates were the most abundant group in Zhuanghe, which accounted for 41.9% of the total phytoplankton abundance. The dominant genera of diatoms in Qinhuangdao were Skeletonema, Thalassiosira and Leptocylindrus, while those in Zhuanghe were Thalassiosira and Cyclotella. Greater biomass and more appropriate structure of phytoplankton contributed to higher growth rate and glycogen content of cultured bay scallops.

Conclusions
Our study characterized the relationship between nutrient concentration, phytoplankton community and scallop mariculture in the main bay scallop farming waters in northern China. The results suggest that, as nutrient limitation intensified, dinoflagellates are becoming the dominant phytoplankton species in the scallop farming waters of the Bohai Sea and the North Yellow Sea, which is harmful to the coastal mariculture.
Efficacy of modified thoracoabdominal nerves block through perichondrial approach in open gynecological surgery: a prospective observational pilot study and a cadaveric evaluation
Authors: Tanaka Nobuhiro , Suzuka Takanori , Kadoya Yuma , Okamoto Naoko , Sato Mariko , Kawanishi Hideaki , Azuma Cho , Nishi Mayumi , Kawaguchi Masahiko 
Published: April 2022

Abstract
Background
Modified thoracoabdominal nerves block through perichondrial approach (M-TAPA) was first described as a peripheral nerve block by Tulgar in 2019. This technique provides an analgesic effective range from Th7–11 with a single puncture per side. Although the efficacy and effective duration of M-TAPA have been reported, further examination is required. Therefore, this study aimed to evaluate the analgesic range and effective duration of M-TAPA in open gynecologic surgery.

Methods
Following approval, 10 adult female patients scheduled for open radical hysterectomy via a vertical incision or laparotomy using a midline incision from under the xiphoid process to the symphysis pubis were enrolled. The primary outcome was the number of anesthetized dermatomes at 2 and 24 h postoperatively. Secondary outcomes included numerical rating scale scores and the total amount of fentanyl used. Cadaveric evaluation was performed to assess the spread of the dye.

Results
The median numbers (interquartile range) of anesthetized dermatomes at 2 and 24 h postoperatively were 6 (5–7) and 6.5 (5–7) in the anterior cutaneous branch area and 5 (4–7) and 7 (5–7) in the lateral cutaneous branch area, respectively. There was an 85% chance of simultaneously acquiring analgesia in areas innervated by Th8–11, including complete block in areas innervated by the anterior cutaneous branches of Th9–10. Cadaveric evaluation showed the spread of the dye in Th8–11.

Conclusions
M-TAPA may have analgesic effects in the areas supplied by the anterior cutaneous branches of Th8–11.

Trail registration
IRB approval (No.2700; registered on July 10, 2020) and registration (UMIN Clinical Trials Registry: UMIN000041137; registered on July 17, 2020).
The correlation between lipoprotein(a) elevations and the risk of recurrent cardiovascular events in CAD patients with different LDL-C levels
Authors: Zhu Lijun , Zheng Jiamin , Gao Beibei , Jin Xiangbo , He Ying , Zhou Liang , Huang Jinyu 
Published: April 2022

Abstract
Background
Lipoprotein(a) [Lp(a)] elevation is an important risk factor for coronary artery disease (CAD). However, the correlation between Lp(a) elevations and the risk of recurrent cardiovascular events in patients with established cardiovascular disease is controversial. Some studies have shown that Low-density lipoprotein cholesterol (LDL-C) levels may influence the association between Lp(a) and cardiovascular risk. Our study aims to explore the correlation between Lp(a) elevations and cardiovascular risk in patients with different LDL-C levels.

Methods
We included 516 patients who received coronary stents due to acute coronary syndrome (ACS) and followed them for three years. They were divided into low-Lp(a) group and high-Lp(a) group according to Lp(a) levels, and the incidence of major adverse cardiovascular events (MACE) and acute coronary events (ACE) was compared between the two groups. Then the patients were divided into three subgroups (S1:LDL-C ≥ 1.8 mmol/L; S2:1.4 ≤ LDL-C < 1.8 mmol/L; S3:LDL-C < 1.4 mmol/L). The correlation between Lp(a) elevations and cardiovascular risk in different subgroups was analysed by Cox proportional hazards models.

Results
The incidence of MACE and ACE in the high-Lp(a) group was significantly higher than those in the low-Lp(a) group (P < 0.05). Lp(a) elevations had independent prognostic value from the statistical point of view (MACE: HR = 1.63, 95%CI = 1.12–2.38, P = 0.012; ACE: HR = 1.70, 95%CI = 1.03–2.81, P = 0.037). Subgroup analysis showed that Lp(a) elevations increased cardiovascular risk when LDL-C ≥ 1.4 mmol/L. However, this correlation no longer existed when LDL-C levels were very low (< 1.4 mmol/L) (MACE: HR = 0.49, 95%CI = 0.17–1.42, P = 0.186; ACE: HR = 0.68, 95%CI = 0.18–2.61, P = 0.570).

Conclusions
Lp(a) elevations are associated with recurrent cardiovascular events when LDL-C levels are high, but this association may change when LDL-C levels are extremely low. CAD patients with combination of LDL-C ≥ 1.4 mmol/L and Lp(a) elevations shall be considered as high-risk groups and require further medication for the reduction of their LDL-C levels.
Addressing chronic pain with Focused Acceptance and Commitment Therapy in integrated primary care: findings from a mixed methods pilot randomized controlled trial
Authors: Kanzler Kathryn E. , Robinson Patricia J. , McGeary Donald D. , Mintz Jim , Kilpela Lisa Smith , Finley Erin P. , McGeary Cindy , Lopez Eliot J. , Velligan Dawn , Munante Mariana , Tsevat Joel , Houston Brittany , Mathias Charles W. , Potter Jennifer Sharpe , Pugh Jacqueline 
Published: April 2022

Abstract
Background
Over 100 million Americans have chronic pain and most obtain their treatment in primary care clinics. However, evidence-based behavioral treatments targeting pain-related disability are not typically provided in these settings. Therefore, this study sought to: 1) evaluate implementation of a brief evidence-based treatment, Focused Acceptance and Commitment Therapy (FACT-CP), delivered by an integrated behavioral health consultant (BHC) in primary care; and 2) preliminarily explore primary (self-reported physical disability) and secondary treatment outcomes (chronic pain acceptance and engagement in valued activities).

Methods
This mixed-methods pilot randomized controlled trial included twenty-six participants with non-cancer chronic pain being treated in primary care (54% women; 46% Hispanic/Latino). Active participants completed a 30-min individual FACT-CP visit followed by 3 weekly 60-min group visits and a booster visit 2 months later. An enhanced treatment as usual (ETAU) control group received 4 handouts about pain management based in cognitive-behavioral science. Follow-up research visits occurred during and after treatment, at 12 weeks (booster visit), and at 6 months. Semi-structured interviews were conducted to collect qualitative data after the last research visit. General linear mixed regression models with repeated measures explored primary and secondary outcomes.

Results
The study design and FACT-CP intervention were feasible and acceptable. Quantitative analyses indicate at 6-month follow-up, self-reported physical disability significantly improved pre-post within the FACT-CP arm (d = 0.64); engagement in valued activities significantly improved within both the FACT-CP (d = 0.70) and ETAU arms (d = 0.51); and chronic pain acceptance was the only outcome significantly different between arms (d = 1.04), increased in the FACT-CP arm and decreased in the ETAU arm. Qualitative data analyses reflected that FACT-CP participants reported acquiring skills for learning to live with pain, consistent with increased chronic pain acceptance.

Conclusion
Findings support that FACT-CP was acceptable for patients with chronic pain and feasible for delivery in a primary care setting by a BHC. Results provide preliminary evidence for improved physical functioning after FACT-CP treatment. A larger pragmatic trial is warranted, with a design based on data gathered in this pilot.

Trial registration
clinicaltrials.gov, NCT04978961 (27/07/2021).
Evaluations of postoperative transitions in care for older adults: a scoping review
Authors: Hladkowicz Emily , Dumitrascu Flavia , Auais Mohammad , Beck Andrew , Davis Sascha , McIsaac Daniel I. , Miller Jordan 
Published: April 2022

AbstractBackgroundMost people having major surgery are over the age of 65. The transition out of hospital is a vulnerable time for older adults, particularly after major surgery. Research on postoperative transitions in care is growing, but it is not clear how postoperative transitions are being evaluated. The objective of this scoping review was to synthesize processes and outcomes used to evaluate postoperative transitions in care for older adults.MethodsWe conducted a scoping review that included articles evaluating a postoperative transition in care among adults aged> 65 having major elective surgery. We searched Medline (Ovid), EMBASE (Ovid), CINHAL, and Cochrane Central Register of Controlled Trials (CENTRAL) from their respective inception dates to April 6, 2021. We also searched The World Health Organization International Clinical Trials Registry Platform andClinicalTrials.govfrom their respective inception dates to April 6, 2021. Screening and data extraction was completed by reviewers in duplicate. Data relevant to study design and objective, intervention description, and process or outcome evaluations were extracted. Process evaluations were categorized using the Ideal Transitions in Care Framework, and outcome evaluations were categorized using the Institute for Healthcare Improvement Triple Aim Framework.ResultsAfter screening titles and abstracts and full-text article review, we included 20 articles in our final synthesis. There was variability in the processes and outcomes used to evaluate postoperative transitions in care. The most common outcomes evaluated were health service utilization (n = 9), including readmission and Emergency Department visits, experiential outcomes (n = 9) and quality of life (n = 7). Process evaluations included evaluating the education provided to patients to promote self-management (n = 6), coordination of care among team members (n = 3) and outpatient follow-up (n = 3). Only two articles measured frailty, one article used theory to guide their evaluations and no articles engaged knowledge users.ConclusionsThere is inconsistency in how postoperative transitions in care were evaluated. There is a need to use theories and to engage key stakeholders involved in postoperative transitions in care, including older adults and their caregivers, to identify the most appropriate approaches for developing and evaluating interventions to meaningfully improve care.
Associations of geriatric nutrition risk index and other nutritional risk-related indexes with sarcopenia presence and their value in sarcopenia diagnosis
Authors: Xiang Qiao , Li Yuxiao , Xia Xin , Deng Chuanyao , Wu Xiaochu , Hou Lisha , Yue Jirong , Dong Birong 
Published: April 2022

Abstract
Objective
Standard modalities recommended for sarcopenia diagnosis may be unavailable in primary care settings. We aimed to comprehensively evaluate and compare associations of some better popularized nutritional risk-related indexes with sarcopenia presence and their value in sarcopenia diagnosis in community-dwelling middle-aged and elderly adults, including geriatric nutrition risk index (GNRI), albumin (ALB), calf circumference (CC), mid-arm circumference (MAC), triceps skinfold thickness (TST) and body mass index (BMI).

Methods
Based on the West China Health and Aging Trend study, the current study included participants aged 50 or older who were recruited in 2018. Sarcopenia-related assessment and diagnosis were in line with Asian Working Group for Sarcopenia 2019. For each single index, we assessed its association with sarcopenia presence by univariate and multivariate logistic regression analysis; we also computed diagnostic measures including the area under the receiver operating characteristic curve (AUC) and sensitivity, specificity, accuracy at the optimal cut-off value determined according to Youden’s index.

Results
A total of 3829 subjects were included, consisting of 516 and 3313 subjects in the sarcopenia and non-sarcopenia groups, respectively. Regarding the risk for sarcopenia presence, the fully adjusted odds ratios of GNRI, ALB, CC, MAC, TST and BMI per standard deviation decrease were 2.95 (95% CI 2.51–3.47, P < 0.001), 1.01 (95% CI 0.90–1.15, P = 0.816), 4.56 (95% CI 3.82–5.44, P < 0.001), 4.24 (95% CI 3.56–5.05, P < 0.001), 1.67 (95% CI 1.92–1.45, P < 0.001) and 4.09 (95% CI 3.41–4.91, P < 0.001), respectively. Regarding the value in sarcopenia diagnosis in the entire study population, their AUCs could be ordered as MAC (0.85, 95% CI 0.83–0.86) > GNRI (0.80, 95% CI 0.78–0.82), CC (0.83, 95% CI 0.81–0.85), BMI (0.81, 95% CI 0.79–0.83) > TST (0.72, 95% CI 0.70–0.74) > ALB (0.62, 95% CI 0.60–0.65). At the relevant optimal cut-off values, the sensitivity was the highest for CC (0.83, 95% CI 0.80–0.87) and MAC (0.80, 95% CI 0.77–0.84), while GNRI showed the highest specificity (0.79, 95% CI 0.78–0.81) and accuracy (0.78, 95% 0.76–0.79).

Conclusion
Overall diagnostic performance was the best for MAC, followed by GNRI, CC, BMI, and the worst for TST, ALB in distinguishing sarcopenia from non-sarcopenia in middle-aged and elderly adults in community-based settings. CC or MAC might do better in reducing missed diagnosis, while GNRI was superior in reducing misdiagnosis.