bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular safety of hormone therapy for prostate cancer
Authors: Andreev D. A. , Zavyalov A. A. 
Published: December 2022

Background. As of 2019, prostate cancer (PCa) is the second most common malignancy in men living in Russia (15.7 % of all cancer cases detected in 2019). Cardiovascular diseases, in particular atherosclerosis, are believed to be the second most frequent cause of death in PCa patients.Aim. To evaluate cardiovascular safety of hormone therapy for PCa on the example of gonadotropin releasing hormone (GnRH) agonists and antagonists (leuprolide and degarelix), second-generation antiandrogens (enzalutamide), and steroidogenesis inhibitors (abiraterone).Materials and methods. We analyzed the results of original studies assessing cardiovascular safety of hormone therapy in PCa patients published in 2020–2021 and indexed in PubMed. The results of other meta-analyses and systematic reviews were not included.The search for publications was performed using the PubMed database and the Google system. The following key words were used for searching: prostate cancer, cardiovascular risks, cardiovascular safety, outcomes, atherosclerosis, etc. We analyzed studies published between January 2020 and January 2022. Articles in English and Russian were selected manually; no filters were applied.Results. We examined the results of the latest and most relevant original studies assessing cardiovascular safety of key innovative hormone therapies for PCa. The majority of recent studies were based on routine clinical practice; they were registered in highly specialized cancer registers.Hormone therapy is associated with cardiotoxicity, which increases the risk of non-cancer related death in PCa patients. New, sometimes conflicting evidence is being constantly accumulated. This evidence suggests that the GnRH antagonist (degarelix) has a better cardiovascular safety profile than the GnRH agonist (leuprolide); enzalutamide is safer than abiraterone. Further search for prognostic biomarkers in PCa patients is needed.Conclusion. More high-quality studies analyzing adverse cardiovascular events in PCa patients conducted in routine clinical practice and registered in the online databases are the next stage to identify benefits of one antitumor drug over another. This will help to choose optimal hormone therapy algorithms for PCa patients and, therefore, increase their overall survival.
Experience of using photodynamic therapy in early stages of penile cancer
Authors: Kapinus V. N. , Karyakin O. B. , Yaroslavtseva-Isaeva E. V. , Popovkina O. E. , Ivanov S. A. , Kaprin А. D. 
Published: December 2022

Background. Penile cancer is a rare oncological pathology. Due to the intimate nature of the affected area and high significance of the organ for psycho-emotional state of the patient, at the early stages of the disease organ-sparing operations are preferred allowing to minimize the effect on patient’s quality of life without affecting oncological results.Aim. To evaluate the effectiveness of treatment of early stages penile cancer using photodynamic therapy (PDT) with chlorin E6 derivatives.Materials and methods. Between 2017 and 2021, PDT with chlorin E6 derivatives to treat early-stage penile cancer was performed in 15 patients between the ages of 29 and 84 years (mean age 56.4 years). Tumor stage was Tin situ–1bN0M0. PDT was performed with preliminary administration of Photolon and Photoran photosensitizers. Laser exposure on the tumor lesions was performed 3 hours after photosensitizer administration using laser device Latus-2 (662 nm), light dose 200–300 J/cm2, power density 0.21–0.41 mW/cm2.Results. After 1 PDT session, full regression was observed in 11 (73.3 %) patients, partial regression in 4 (26.7 %) patients who underwent 2nd session 2 months later with full effect. Therefore, in all patients full regression of the tumors was achieved. Follow-up duration was 6–56 months. Recurrence was diagnosed in 1 (6.7 %) patient 36 months after PDT, 14 (93.3 %) patients are under observation without signs of local recurrence, among them for more than 4 years – 3 men, more than 3 years – 1, more than 2 years – 3, more than 1 year – 4 and more than 6 months – 3. During the follow-up, no regional or distant metastases were observed in any of the patients.Conclusion. PDT with chlorin E6 derivatives is an effective organ-sparing treatment method for early-stage penile cancer with satisfactory oncological results without negative effect on patients’ quality of life. In 93.3 % of patients, local recurrence of the disease was not observed; during follow-up no distant metastases were diagnosed. It is necessary to point out satisfactory cosmetic results of the treatment: in all patients, elastic non-deforming scars were formed with full preservation of anatomical structures of the penis, no erectile dysfunction or disruption of urination were observed after PDT.
Caracterización del microbioma de plantas de banano (Musa × paradisiaca L.) bajo sistemas de producción orgánico y convencional
Authors: Zapata-Ramón Claudia G. , Paladines-Montero Alejandra , León-Reyes Antonio , Ramírez-Villacís Darío X. 
Published: December 2022

El cultivo de banano (Musa × paradisiaca L.) es una de las actividades agrícolas más importantes para muchos países y es la principal fruta consumida mundialmente. La fertilización química es una de las prácticas más comunes utilizada para aumentar el rendimiento y productividad de los cultivos. Una gran cantidad de literatura examina los cambios en las propiedades del suelo asociados con diferentes regímenes de fertilización. A pesar del papel fundamental del microbioma en la salud y la productividad de las plantas, los efectos de los diferentes sistemas de gestión agrícola sobre las comunidades microbianas son poco estudiados. Este estudio informa la estructura, diversidad y riqueza de la comunidad microbiana del suelo, rizosfera y hoja de las plantas de banano bajo manejo orgánico y convencional. Se obtuvieron muestras de dos plantaciones bananeras ubicadas en El Oro, una de las provincias con mayor productividad bananera en Ecuador. El análisis se basó en la secuenciación de ADN de la región V3-V4 del gen del ARNr 16S para bacterias y la región ITS2 para hongos. Se encontró un efecto significativo del sistema de manejo en la composición de la comunidad bacteriana y fúngica. En términos generales, bajo un sistema de manejo convencional, la riqueza y uniformidad de la comunidad bacteriana y fúngica aumentó entre las muestras de suelo y rizosfera en comparación con el sistema de agricultura orgánica. El suelo y la rizosfera bajo agricultura orgánica se asociaron con una mayor abundancia relativa de Proteobacteria, Firmicutes y Bacteroidetes y exhibieron una sobrerrepresentación de géneros microbianos conocidos como promotores del crecimiento de plantas, así como géneros involucrados en procesos importantes del ecosistema. También encontramos que los ASV del mismo género responden diferente a los dos tipos de manejo agrícola en el suelo y la rizosfera. Mientras que las comunidades bacterianas en las hojas fueron más similares en ambos tipos de manejo. Comprender cómo los sistemas de gestión de cultivos a largo plazo modifican la diversidad y la estructura microbiana, como se presenta en esta investigación, puede ayudar a diseñar sistemas agrícolas que puedan mantener una alta rentabilidad de los cultivos de banano mediante la estimulación de bacterias promotoras del crecimiento y supresoras de las enfermedades transmitidas por el suelo.
The Quality of Online Education for Theoretical Courses of Audiology from the Perspective of Audiology Students at Tehran University of Medical Sciences during the COVID-19 Pandemic
Authors: Roghani Zohreh , Farahani Saeid , Fatahi Farzaneh , Ghotbi Nastaran , Jalaie Shohreh 
Published: December 2022

Background and Aim: The face-to-face education was suspended during the COVID-19 pandemic. In such situations, online education method was used. In this study, we aim to assess the quality of online education for theoretical courses of audiology from the perspective of audiology students at Tehran University of Medical Sciences (TUMS) during the COVID-19 pandemic.
Methods: This comparative cross-sectional study was conducted on 77 audiology students of the School of Rehabilitation at TUMS. Data collection were a demographic form and two quality and satisfaction assessment questionnaires. Statistical analysis was performed in SPSS version 17.
Results: There was a significant difference in all subscales of Shourcheh questionnaire among students with different educational stages (p<0.05), but there was no significant difference between age (except for social solidarity component) and gender (p>0.05) groups. The results of Kruskal-Wallis test showed a statistically significant difference in the quality scores among students with different educational stages (p=0.033), but there was no significant difference between age (p=0.300) and gender (p=0.630) groups.
Conclusion: The quality of online education for theoretical courses of audiology at TUMS is high from the perspective of PhD students, while it is low according to BSc and MSc students.
Keywords: Audiology; virtual education; COVID-19; pandemic; students
Neonatal Hearing Screening and Prevalence of Hearing Impairment in the Time Period of COVID-19 Epidemic in the North of Iran
Authors: Panahi Rasool , Nemati Shadman , Akbarpour Maliheh , Nasirmohtaram Sevil , Maroufizadeh Saman , Hosseinian Alemeh 
Published: December 2022

Background and Aim: COVID-19 is an acute respiratory disease, caused by a coronavirus named SARS-CoV-2. Previous reports suggest an association between COVID-19 infection and Hearing Loss (HL). We have investigated the Universal Newborn Hearing Screening (UNHS) results in the time period of COVID-19 epidemic in Guilan Province, north of Iran.
Methods: We analyzed UNHS results from10 major obstetrics hospitals from 20th Mar 2020 to 19th Mar 2021, and compared the total UNHS positive/“refer” and total neonatal HL reports with the same time periods of recent three years. The prevalence of risk factors for HL were analyzed during the same period.
Results: The total number of childbirth was decreased significantly from 27735 birth cases in Mar 2017-2018 to 18216 births in Mar 2020-2021 (p<0.001), but the total “refer” rate was significantly increased from 63.0 per 1,000 births in Mar 2019-2020 to 79.8 in Mar 2020-2021 (OR=1.29, 95% CI: 1.19-1.39, p<0.001), and also increased from 74.7 per 1,000 births in Mar 2017-2020 to 79.8 in Mar 2020-2021 (OR=1.07, 95% CI: 1.01-1.14, p=0.020). The HL rate increased from 10.3 per 10,000 births in Mar 2019-2020 and from 11.4 per 10,000 births in Mar 2017-2020 to 18.7 in Mar 2020-2021 (OR=1.81 and 1.63, 95% CI: 1.06-3.09 and 1.10-2.44, p=0.028 and 0.015, respectively). The prevalence of preterm birth (p=0.039) and neonatal intensive care unit stay (p=0.016) was increased significantly during Mar 2020-2021.
Conclusion: The chance of “refer” results and neonatal HL, found in the UNHS program, increased during the COVID-19 epidemic in comparison to the past years.
Keywords: Newborn; hearing screening; hearing loss; COVID-19
Short-Term Effects of Weight Loss after Bariatric Surgery on Respiratory and Skeletal Muscles’ Strength
Authors: Mehdinavaz Abdolreza , Najjari Khosrow , Talebpour Mohammad , Zabihi-Mahmoudabadi Hossein , Rajabian Tabesh Mastaneh , Elyasinia Fezzeh , Kor Farhad , Fattahi MohammadReza , Abolhasani Maryam 
Published: December 2022

Background: Bariatric surgery leads to weight loss and body fat percentage reduction, but patients are prone to lean tissue loss which itself reduces the quality of life, and increases the risk of deatand h. This study evaluated the effects of bariatric surgery and changes in Fat Mass (FM) and Fat-Free Mass (FFM) on the respiratory and skeletal muscles’ strength three months after bariatric surgery.
Methods: After obtaining demographic information, anthropometric measurements and body composition analysis, including Body Mass Index (BMI), FM, FFM, Percent Body Fat (PBF), handgrip isometric force, respiratory muscle forces and spirometry volumes, were assessed before and three months after bariatric surgery in 50 men and women undergoing this surgery.
Results: Weight, BMI, FM, PBF and FFM isometric muscle force were decreased significantly. In contrast, respiratory muscle forces and respiratory volumes were increased significantly three months after the surgery. Reduction in FFM 3 months after the surgery did not lead to a change in respiratory muscle strength (p-values≥0.05).
Conclusion: According to our findings, FM and FFM along with weight and BMI decrease significantly after bariatric surgery. These alternations were accompanied by a significant increase in respiratory muscle strength but were not correlated with handgrip muscle force changes.
Source material creation for high content of dry soluble substances F<sub>1</sub> cherry tomato hybrids breeding
Authors: Gavrish S. F. , Redichkina T. A. , Topinskiy A. I. 
Published: December 2022

Relevance. Consumer demand development of exotic colors presence in modern tomato hybrids requires a timely response from domestic breeders for creating highly effective hybrids. With regard to cherry tomatoes, special attention of breeders is aimed at achieving excellent taste in new hybrids. One of the indicators is the "content of dry soluble substances in fruits". However, there is no information in the literature about the variation of this trait within different color groups of cherry tomatoes. The aim of our work was the creation of initial material for the selection of F1 cherry tomato hybrids with a high content of dry soluble substances.Materials and methods. All measurements were obtained by the refractometric method and presented in the oBrix scale. The study examined 46 F2 splitting cherry tomato populations, including 17 red, 12 yellow, 7 pink, 8 brown, and 2 purple. Analyzing the obtained data, the following statistical indicators were made: the frequency of occurrence of the variant; arithmetic mean; dispersion; the coefficient of variation; sample mean error. Relative error was used to test the sample results obtained.Results. The coefficients of variation of the trait «content of dry soluble substances in fruits» were calculated in each of the five color groups of cherry tomatoes (from 17.43% for brown-fruited to 25.13% for red-fruited). The boundaries of variability and average values of the content of dry soluble substances were determined both within the groups (from 7.2 oBr in pink-fruited to 8.8 oBr in yellow-fruited ones), and for each studied breeding sample. The practical result of the work was selection of the most promising breeding material within different color groups of cherry tomato, combining high values of dry matter with a complex of economically valuable traits.
Biochemical content and yield of some cultivars of green bean (<I>Phaseolus vulgaris</I> L.) under Moscow region conditions
Authors: Antoshkin A. A. , Molchanova A. V. , Smirnova A. M. 
Published: December 2022

Relevance. Increased demand in Russia for common bean (Phaseolus vulgaris L.) varieties of domestic breeding has stimulated the Federal Scientific Vegetable Center of breeding to intensify research on the creation of new asparagus bean varieties of vegetable direction.Materials and methods. Four vegetable bean varieties – Secunda, Lika, Ulyasha, Si Bemol of the laboratory of selection and seed production of vegetable Legume crops of the Federal Scientific Vegetable Center were used as the material for the study. The counts and observations were made according to the Methodology of the State Variety Trial of Agricultural Crops, 1975. The count of productivity was carried out in the technical stage of ripeness by replications. Harvesting was carried out when the biological stage of ripeness was reached. Biochemical studies of plants were carried out in the laboratoryanalytical department of the FSBSI FSVC. The biochemical composition of vegetable bean (green bean) varieties was studied according to the following indicators: determination of the total content of water-soluble antioxidants, ascorbic acid, dry matter, polyphenols, monosaccharides, total sugar content and starch.Results. Evaluation of samples by aggregate factors contributes to the selection of the most promising and high-quality varieties for their introduction into production. As a result of the research of vegetable bean on the main economically valuable features and biochemical composition for the period from 2018 to 2020, the varieties Lika and Ulyasha were selected. They were distinguished by high productivity of beans and seeds. Green bean variety Lika was noted for the highest total content of water-soluble antioxidants, ascorbic acid and the total of sugars content, the green bean variety "lobio" Ulyasha - high content of polyphenols and the total of antioxidants in the alcohol extract. Stable high yield, adaptive potential and high quality of beans, confirmed by the results of biochemical evaluation, allow us to recommend these varieties for consumption by the population as part of the diet and as an alternative to meat and dairy products.
Assessment of Bukola Saraki Administration in Kwara State of Nigeria (2003-2011)
Authors: Ogundare Yemi Daniel 
Published: December 2022

Abstract
The paper examines the assessment of the Bukola Saraki Administration 2003-2011. The administration is an act of getting things achieved through the people; it requires leadership quality, ideology, and value. The historical analysis of Kwara State administrations in the fourth republic is not complete without considering the political dynastic transfer of Olusola Saraki to a biological son Bukola Saraki in the political process of Kwara State as a governor. The objective of this paper is to assess the success and failure of the Peoples Democratic Party (PDP) in Kwara State during the Abubakar Bukola Saraki administrations. The theory employed in this paper is the Stakeholders theory, which is relevant to this work. The research methodology is a secondary source and analytical. The findings of the paper identify the successes and limitations of PDP administrations from 2003-2011. The paper recommends democratic lifestyle leadership with transparency and accountability government to the citizen as the best set of administration to be practiced in any polity.
Viability and Antibacterial Activity of Bifidobacterium bifidum in Fermented Robusta Coffee for Diarrhea Treatment
Authors: Miksusanti  , Apriani Elsa Fitria , Hidayat Dimas Nur 
Published: December 2022

Background: Diarrhea can be treated with probiotic bacteria such as Bifidobacterium bifidum, which decreases the intestinal environment's pH to become acidic so that pathogenic bacteria cannot thrive. Objective: To make fermented coffee that can increase the number of probiotic bacteria Bifidobacterium bifidum and has antidiarrheal activity against pathogenic bacteria Escherichia coli. Methods: Robusta coffee (20.25% and 19.75%) was fermented using Saccharomyces cerevisiae, and then the probiotic bacteria Bifidobacterium bifidum was added. Unfermented coffee was compared with the same concentration (20.25% and 19.75%) to obtain four formulas. Organoleptic panelists tested all formulas to determine the best formula for fermented and non-fermented coffee. The number of Bifidobacterium bifidum and antibacterial activity was calculated on the optimum formulation using the Total Plate Count and Disc Diffusion Method. Result: The optimum formula obtained at fermented and unfermented coffee concentration was 20,25%. The number of probiotic bacteria Bifidobacterium bifidum growing in fermented and non-fermented coffee was 7.3 x 108 ± 32.4 and 3.1 x 108 ± 30.7 (p < 0.05). The diameter of the inhibition zone of the best fermented and non-fermented coffee was 11.5 ± 0.5 mm and 8.5 ± 0.5 mm, respectively (p < 0.05). Conclusion: Fermented coffee can increase the growth of the probiotic bacteria Bifidobacterium bifidum and has strong antibacterial activity against Escherichia coli bacteria.
THE EFFECTIVENESS OF COOPERATIVE LEARNING IN DEVELOPING GRAMMAR SKILLS
Authors: Odehova Nataliia , Nevska Yuliia , Perlova Viktoriia 
Published: December 2022

The article presents the results of the experimental enquiry aimed at studying the impact of cooperative learning on improving grammar skills. The research focused on two interaction modes – pair work and group work, which were compared in terms of their potential to address accuracy. The experiment was carried out in the first term of the 2020-2021 academic year (September-October). The participants included 23 third-year students of the Foreign Philology Faculty of H. S. Skovoroda Kharkiv National Pedagogical University and constituted two academic groups, with one being offered pair-work activities and the other working in small groups. The experimental study comprised three phases: pre-experiment testing, teaching, post-experiment testing. Both quantitative and qualitative methods were used. The results demonstrate the validity of the assumption about the efficacy of pair work and group work in promoting accuracy, at the same time indicating no statistically significant difference between the two modes. The presented evidence suggests that grammar instruction can clearly benefit from incorporating both pair work and group work into classroom practices, however further research might be advisable to maximize the effectiveness of these interaction patterns by refining the procedure involved and improving students’ cooperative learning skills.
Chromatic Number of Amalgamation of Wheel Graph-Star Graph and Amalgamation of Wheel Graph-Sikel Graph
Authors: Kuswardi Yemi , Almira Luthfi , Nurussakbana Novita , Pinilih Anggoro Canggih 
Published: December 2022

<p>A graph denoted by is a pair of where is a non-empty set of vertices in G, and E is a set of edges in G. In graph theory, there are various types of graphs including star graphs, cycle graph, and wheel graph. Graph operations on two or more types of graphs can produce new graphs. Amalgamation is one of the operations on graphs. Suppose and are two connected graphs, amalgamating the vertices of graph 1 and graph 2 by joining vertices and vertices denoted by is the graph obtained by joins vertex of graph and vertex of graph into one vertex , where is the common vertex of the graph resulting from , while amalgamating the edges of graph and graph by joining edges and edge , denoted by are graphs obtained by combining edge of graph 1 and edge of graph 2 into one edge g, where g is common side of graph of (𝐺1,𝐺2;𝑒,𝑓). Vertex coloring is one of the fastest-growing topics in graphs. The coloring of the vertices, that is, assigning a color to each vertex of the graph so that each neighboring vertex has a different color. The minimum number of colors used to color the vertices of a graph is called the chromatic number. In this article, we discuss the chromatic number in the amalgamated graph of wheel graph and star graph and the chromatic number on the amalgamation of wheel graph and cycle graph. The results obtained are as follows: (1) the chromatic number of the amalgamated graph of the wheel graph () and the star graph () for n even is 3 and for n odd is 4, (2) the chromatic number of the graph resulting from the operation amalgamation of the wheel graph () and the cycle graph () for n even is 3 and for odd is 4.</p>