bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orbital and In‐Situ Investigation of Periodic Bedrock Ridges in Glen Torridon, Gale Crater, Mars
Authors: Stack Kathryn M. , Dietrich William E. , Lamb Michael P. , Sullivan Robert J. , Christian John R. , Newman Claire E. , O’Connell‐Cooper Catherine D. , Sneed Jonathan W. , Day Mackenzie , Baker Mariah , Arvidson Raymond E. , Fedo Christopher M. , Khan Sabrina , Williams Rebecca M. E. , Bennett Kristen A. , Bryk Alexander B. , Cofield Shannon , Edgar Lauren A. , Fox Valerie K. , Fraeman Abigail A. , House Christopher H. , Rubin David M. , Sun Vivian Z. , Van Beek Jason K. 
Published: May 2022

AbstractGale crater, the field site for NASA's Mars Science Laboratory Curiosity rover, contains a diverse and extensive record of aeolian deposition and erosion. This study focuses on a series of regularly spaced, curvilinear, and sometimes branching bedrock ridges that occur within the Glen Torridon region on the lower northwest flank of Aeolis Mons, the central mound within Gale crater. During Curiosity's exploration of Glen Torridon between sols ∼2300–3080, the rover drove through this field of ridges, providing the opportunity for in situ observation of these features. This study uses orbiter and rover data to characterize ridge morphology, spatial distribution, compositional and material properties, and association with other aeolian features in the area. Based on these observations, we find that the Glen Torridon ridges are consistent with an origin as wind‐eroded bedrock ridges, carved during the exhumation of Mount Sharp. Erosional features like the Glen Torridon ridges observed elsewhere on Mars, termed periodic bedrock ridges (PBRs), have been interpreted to form transverse to the dominant wind direction. The size and morphology of the Glen Torridon PBRs are consistent with transverse formative winds, but the orientation of nearby aeolian bedforms and bedrock erosional features raise the possibility of PBR formation by a net northeasterly wind regime. Although several formation models for the Glen Torridon PBRs are still under consideration, and questions persist about the nature of PBR‐forming paleowinds, the presence of PBRs at this site provides important constraints on the depositional and erosional history of Gale crater.
An Outlook for the Acquisition of Marine Sedimentary Ancient DNA (sedaDNA) From North Atlantic Ocean Archive Material
Authors: Selway Caitlin A. , Armbrecht Linda , Thornalley David 
Published: May 2022

AbstractStudies incorporating sedimentary ancient DNA (sedaDNA) analyses to investigate paleo‐environments have increased considerably over the last few years, and the possibility of utilizing archived sediment cores from previous field campaigns could unlock an immense resource of sampling material for such paleo‐investigations. However, sedaDNA research is at a high risk of contamination by modern environmental DNA, as sub‐optimal sediment storage conditions may allow for contaminants (e.g., fungi) to grow and become dominant over preserved sedaDNA in the sample. Here, we test the feasibility of sedaDNA analysis applied to archive sediment material from five sites in the North Atlantic, collected between 1994 and 2013. We analyzed two samples (one younger and one older) per site using a metagenomic shotgun approach and were able to recover eukaryotic sedaDNA from all samples. We characterized the authenticity of each sample through sedaDNA fragment size and damage analyses, which allowed us to disentangle sedaDNA and contaminant DNA. Although we determined that contaminant sequences originated mainly from Ascomycota (fungi), most samples were dominated by Emiliania huxleyi, a haptophyte species that commonly blooms in the study region. We attribute the presence of contaminants to non‐ideal sampling and sample storage conditions of the investigated samples. Therefore, while we demonstrate that sedaDNA analysis of archival North Atlantic seafloor sediment samples are generally achievable, we stress the importance of best‐practice ship‐board sampling techniques and storage conditions to minimize contamination. We highly recommend the application of robust bioinformatic tools that help distinguish ancient genetic signals from modern contaminants, especially when working with archive material.
Interdecadal Variation in Available Potential Energy of Stationary Eddies in the Midlatitude Northern Hemisphere in Response to the North Pacific Gyre Oscillation
Authors: Leung M. Y.‐T. , Wang D. , Zhou W. , Zhang Y. , Wang L. 
Published: May 2022

AbstractThis study investigates the variation in available potential energy of stationary eddies in the mid‐troposphere over the midlatitude Northern Hemisphere (30°–60°N) from 1950 to 2021, based on the ERA5 reanalysis and its preliminary back extension. The variation is attributed mainly to changes in the wavenumber‐1 eddy. It is also noted that potential energy conversion from the zonal mean flow in early winter plays an important role in the 20‐year variation. In addition, statistical analysis and numerical simulation of an ICTP model demonstrate that the potential energy conversion is controlled by the North Pacific Gyre Oscillation, which induces anomalous meridional temperature advection in the mid‐troposphere over Northeast Asia.
New Paleomagnetic Insights Into the Neoproterozoic Connection Between South China and India and Their Position in Rodinia
Authors: Chang Linxi , Zhang Shihong , Li Haiyan , Xian Hanbiao , Wu Huaichun , Yang Tianshui 
Published: May 2022

AbstractA paleogeographic affinity of the south China craton (SCC) with India in the Neoproterozoic has long been advocated based on lines of geological evidence. However, the lack of coeval paleomagnetic data renders the putative connection ambiguous. Here we report new paleomagnetic results obtained from seven ca. 770 Ma mafic sills in SCC that provide new critical constraints on the issue. The data quality is assured by a positive regional tilt test, a reversal test, and by adequately averaging‐out paleosecular variation. Our data, together with coeval poles from the global paleomagnetic database, support a reconstruction in which the SCC was connected with India at ca. 770 Ma via linkages with smaller continental blocks. The SCC‐India landmass was located at high‐to‐mid latitudes and far from Laurentia and Australia, which were located at low latitudes at ca. 770 Ma.
Variations in Vertical CO/CO2 Profiles in the Martian Mesosphere and Lower Thermosphere Measured by the ExoMars TGO/NOMAD: Implications of Variations in Eddy Diffusion Coefficient
Authors: Yoshida Nao , Nakagawa Hiromu , Aoki Shohei , Erwin Justin , Vandaele Ann Carine , Daerden Frank , Thomas Ian , Trompet Loïc , Koyama Shungo , Terada Naoki , Neary Lori , Murata Isao , Villanueva Geronimo , Liuzzi Giuliano , Lopez‐Valverde Miguel Angel , Brines Adrian , Modak Ashimananda , Kasaba Yasumasa , Ristic Bojan , Bellucci Giancarlo , López‐Moreno José Juan , Patel Manish 
Published: May 2022

AbstractUsing the Nadir and Occultation for MArs Discovery instrument aboard Trace Gas Orbiter, we derived the CO/CO2 profiles between 75 and 105 km altitude with the equivalent width technique. The derived CO/CO2 profiles showed significant seasonal variations in the southern hemisphere with decreases near perihelion and increases near aphelion. The estimation of the CO/CO2 profiles with a one‐dimensional photochemical model shows that an altitude‐dependent eddy diffusion coefficient better reproduces the observed profiles than a vertically uniform one. Our estimation suggests that the eddy diffusion coefficient in Ls = 240–270 is uniformly larger by a factor of ∼2 than that in Ls = 90–120 in the southern hemisphere, while they are comparable in the northern hemisphere. This fact demonstrates that the eddy diffusion coefficient is variable with season and latitude.
Changing causes of death in persons with haematological cancers 1975–2016
Authors: Chen Lezong , Zheng Yongqiang , Yu Kai , Chen Shuzhao , Wang Weida , Gale Robert Peter , Liu Ze-Xian , Liang Yang 
Published: May 2022

AbstractCauses of death in persons with haematological cancers include the index cancer, a new cancer or a seemingly unrelated cause such as cardio-vascular disease. These causes are complex and sometimes confounded. We analyzed trends in cause of death in 683,333 persons with an index haematological cancer diagnosed in 1975–2016 reported in the Surveillance, Epidemiology and End Results dataset. Non-cancer deaths were described using standardized mortality ratios. The index cancer was the predominant cause of death amongst persons with plasma cell myeloma, acute lymphoblastic leukaemia and acute myeloid leukaemia. Non-cancer death was the major cause of death in persons with chronic lymphocytic leukaemia, Hodgkin lymphoma and chronic myeloid leukaemia, mostly from cardio-vascular diseases. The greatest relative decrease in index-cancer deaths was amongst persons with Hodgkin lymphoma, chronic myeloid leukaemia and chronic lymphocytic leukaemia, where the proportion of non-cancer deaths increased substantially. Changing distribution of causes of death across haematological cancers reflects substantial progress in some cancers and suggests strategies to improve the survival of persons with haematological cancers in the future.
Enhancing sensitivity in atomic force microscopy for planar tip-on-chip probes
Authors: Çiftçi H. Tunç , Verhage Michael , Cromwijk Tamar , Pham Van Laurent , Koopmans Bert , Flipse Kees , Kurnosikov Oleg 
Published: May 2022

AbstractWe present a new approach to tuning-fork-based atomic force microscopy for utilizing advanced “tip-on-chip” probes with high sensitivity and broad compatibility. Usually, such chip-like probes with a size reaching 2 × 2 mm2 drastically perturb the oscillation of the tuning fork, resulting in poor performance in its intrinsic force sensing. Therefore, restoring initial oscillatory characteristics is necessary for regaining high sensitivity. To this end, we developed a new approach consisting of three basic steps: tuning-fork rebalancing, revamping holder-sensor fixation, and electrode reconfiguration. Mass rebalancing allows the tuning fork to recover the frequency and regain high Q-factor values up to 104 in air and up to 4 × 104 in ultra-high vacuum conditions. The floating-like holder-fixation using soft wires significantly reduces energy dissipation from the mounting elements. Combined with the soft wires, reconfigured electrodes provide electrical access to the chip-like probe without intervening in the force-sensing signal. Finally, our easy-to-implement approach allows converting the atomic force microscopy tip from a passive tool to a dedicated microdevice with extended functionality.
IGF-1 release in the medial prefrontal cortex mediates the rapid and sustained antidepressant-like actions of ketamine
Authors: Deyama Satoshi , Kondo Makoto , Shimada Shoichi , Kaneda Katsuyuki 
Published: May 2022

AbstractKetamine, an N-methyl-D-aspartate receptor antagonist, exerts rapid and sustained antidepressant actions. Preclinical studies demonstrated that the release of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor in the medial prefrontal cortex (mPFC) is essential for the antidepressant-like effects of ketamine. However, the role of other neurotrophic factors in the antidepressant-like effects of ketamine has not been fully investigated. Since the intra-mPFC infusion of insulin-like growth factor 1 (IGF-1) reportedly produced antidepressant-like effects, the present study examined the role of endogenous intra-mPFC IGF-1 signaling in the antidepressant-like actions of ketamine. In vivo microdialysis showed that ketamine (10 and 30 mg/kg) significantly increased extracellular IGF-1 levels in the mPFC of male C57BL/6J mice for at least 5 h. Infusion of an IGF-1 neutralizing antibody (nAb; 160 ng/side) into the mPFC 15 min before or 2 h after ketamine injection blocked the antidepressant-like effects of ketamine in three different behavioral paradigms (forced swim, female urine sniffing, and novelty-suppressed feeding tests were conducted 1, 3 and 4 days post-ketamine, respectively). The ketamine-like antidepressant-like actions of the intra-mPFC infusion of BDNF (100 ng/side) and IGF-1 (50 ng/side) respectively were not blocked by co-infused IGF-1 nAb and BDNF nAb (200 ng/side). Moreover, intra-mPFC infusion of IGF-1 nAb 2 h post-ketamine blocked the antidepressant-like effects of ketamine in a murine lipopolysaccharide (LPS)-induced depression model. Intra-mPFC IGF-1 infusion also produced antidepressant-like effects in the LPS-challenged mice via mechanistic target of rapamycin complex 1 activation. These results suggest that persistent release of IGF-1, independently of BDNF, in the mPFC is essential for the antidepressant-like actions of ketamine.
SFMBT1 facilitates colon cancer cell metastasis and drug resistance combined with HMG20A
Authors: Pan Ruijun , Yu Dingye , Hu Jiajia , Yang Xiao , Wang Chenxing , Zhang Luyang , Xue Pei , Sun Jing , Zhang Xiaoping , Cai Wei 
Published: May 2022

AbstractIn colorectal cancer (CRC), the development of reagents that increase sensitivity to chemotherapeutic agents could prevent drug resistance and improve patient survival. Scm-like with four malignant brain tumor domains 1 (SFMBT1) is up-regulated in CRC tumor tissues and cells and may be associated with drug resistance. We detected the expression of SFMBT1 in CRC tissue microarrays by immunohistochemistry. The role of SFMBT1 in the migration, proliferation and invasion of CRC or resistance to 5-fluorouracil (5-FU) was determined using scratch assay, colony formation and Transwell assay. Fluorescence co-localization and immunoprecipitation were used to analyze the correlation between SFMBT1 and high mobility group domain-containing protein 20 A (HMG20A). Xenograft experiments were conducted to investigate the role of SFMBT1 and HMG20A in tumor growth and metastasis in vivo. We found that SFMBT1 is up-regulated in CRC and its expression is further amplified in 5-FU resistance. SFMBT1 drives 5-FU resistance and CRC proliferation, migration and invasion. Correlation analysis shows that SFMBT1 and HMG20A are positively correlated. Mechanistically, fluorescence co-localization and immunoprecipitation assay indicate an interaction between SFMBT1 and HMG20A. Depletion of SFMBT1 down-regulates HMG20A downstream. These results were verified by murine xenograft and lung metastasis models. Our results indicate that the SFMBT1/HMG20A axis could be targeted to increase the resistance of CRC cells to 5-FU.
Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis
Authors: Kiweler Nicole , Delbrouck Catherine , Pozdeev Vitaly I. , Neises Laura , Soriano-Baguet Leticia , Eiden Kim , Xian Feng , Benzarti Mohaned , Haase Lara , Koncina Eric , Schmoetten Maryse , Jaeger Christian , Noman Muhammad Zaeem , Vazquez Alexei , Janji Bassam , Dittmar Gunnar , Brenner Dirk , Letellier Elisabeth , Meiser Johannes 
Published: May 2022

AbstractMetastasis is the most common cause of death in cancer patients. Canonical drugs target mainly the proliferative capacity of cancer cells, which leaves slow-proliferating, persistent cancer cells unaffected. Metabolic determinants that contribute to growth-independent functions are still poorly understood. Here we show that antifolate treatment results in an uncoupled and autarkic mitochondrial one-carbon (1C) metabolism during cytosolic 1C metabolism impairment. Interestingly, antifolate dependent growth-arrest does not correlate with decreased migration capacity. Therefore, using methotrexate as a tool compound allows us to disentangle proliferation and migration to profile the metabolic phenotype of migrating cells. We observe that increased serine de novo synthesis (SSP) supports mitochondrial serine catabolism and inhibition of SSP using the competitive PHGDH-inhibitor BI-4916 reduces cancer cell migration. Furthermore, we show that sole inhibition of mitochondrial serine catabolism does not affect primary breast tumor growth but strongly inhibits pulmonary metastasis. We conclude that mitochondrial 1C metabolism, despite being dispensable for proliferative capacities, confers an advantage to cancer cells by supporting their motility potential.
Dynamic recognition and mirage using neuro-metamaterials
Authors: Qian Chao , Wang Zhedong , Qian Haoliang , Cai Tong , Zheng Bin , Lin Xiao , Shen Yichen , Kaminer Ido , Li Erping , Chen Hongsheng 
Published: May 2022

AbstractBreakthroughs in the field of object recognition facilitate ubiquitous applications in the modern world, ranging from security and surveillance equipment to accessibility devices for the visually impaired. Recently-emerged optical computing provides a fundamentally new computing modality to accelerate its solution with photons; however, it still necessitates digital processing for in situ application, inextricably tied to Moore’s law. Here, from an entirely optical perspective, we introduce the concept of neuro-metamaterials that can be applied to realize a dynamic object- recognition system. The neuro-metamaterials are fabricated from inhomogeneous metamaterials or transmission metasurfaces, and optimized using, such as topology optimization and deep learning. We demonstrate the concept in experiments where living rabbits play freely in front of the neuro-metamaterials, which enable to perceive in light speed the rabbits’ representative postures. Furthermore, we show how this capability enables a new physical mechanism for creating dynamic optical mirages, through which a sequence of rabbit movements is converted into a holographic video of a different animal. Our work provides deep insight into how metamaterials could facilitate a myriad of in situ applications, such as illusive cloaking and speed-of-light information display, processing, and encryption, possibly ushering in an “Optical Internet of Things” era.
Earth’s geodynamic evolution constrained by 182W in Archean seawater
Authors: Mundl-Petermeier A. , Viehmann S. , Tusch J. , Bau M. , Kurzweil F. , Münker C. 
Published: May 2022

AbstractRadiogenic isotope systems are important geochemical tools to unravel geodynamic processes on Earth. Applied to ancient marine chemical sediments such as banded iron formations, the short-lived 182Hf-182W isotope system can serve as key instrument to decipher Earth’s geodynamic evolution. Here we show high-precision 182W isotope data of the 2.7 Ga old banded iron formation from the Temagami Greenstone Belt, NE Canada, that reveal distinct 182W differences in alternating Si-rich (7.9 ppm enrichment) and Fe-rich (5.3 ppm enrichment) bands reflecting variable flux of W from continental and hydrothermal mantle sources into ambient seawater, respectively. Greater 182W excesses in Si-rich layers relative to associated shales (5.9 ppm enrichment), representing regional upper continental crust composition, suggest that the Si-rich bands record the global rather than the local seawater 182W signature. The distinct intra-band differences highlight the potential of 182W isotope signatures in banded iron formations to simultaneously track the evolution of crust and upper mantle through deep time.
Abnormal nonlinear optical responses on the surface of topological materials
Authors: Xu Haowei , Wang Hua , Li Ju 
Published: May 2022

AbstractThe nonlinear optical (NLO) responses of topological materials are under active research. Most previous works studied the surface and bulk NLO responses separately. Here we develop a generic Green’s function framework to investigate the surface and bulk NLO responses together. We reveal that the topological surface can behave disparately from the bulk under light illumination. Remarkably, the photocurrents on the surface can flow in opposite directions to those in the bulk interior, and the light-induced spin current on the surface can be orders of magnitude stronger than its bulk counterpart on a per-volume basis. We also study the responses under inhomogeneous field and higher-order NLO effect, which are all distinct on the surface. These anomalous surface responses suggest that light can be a valuable tool for probing the surface states of topological materials. Besides, the surface effects should be prudently considered when investigating the optical properties of topological materials.
Ultrafast proton-coupled isomerization in the phototransformation of phytochrome
Authors: Yang Yang , Stensitzki Till , Sauthof Luisa , Schmidt Andrea , Piwowarski Patrick , Velazquez Escobar Francisco , Michael Norbert , Nguyen Anh Duc , Szczepek Michal , Brünig Florian Nikolas , Netz Roland Rüdiger , Mroginski Maria Andrea , Adam Suliman , Bartl Franz , Schapiro Igor , Hildebrandt Peter , Scheerer Patrick , Heyne Karsten 
Published: May 2022

AbstractThe biological function of phytochromes is triggered by an ultrafast photoisomerization of the tetrapyrrole chromophore biliverdin between two rings denoted C and D. The mechanism by which this process induces extended structural changes of the protein is unclear. Here we report ultrafast proton-coupled photoisomerization upon excitation of the parent state (Pfr) of bacteriophytochrome Agp2. Transient deprotonation of the chromophore’s pyrrole ring D or ring C into a hydrogen-bonded water cluster, revealed by a broad continuum infrared band, is triggered by electronic excitation, coherent oscillations and the sudden electric-field change in the excited state. Subsequently, a dominant fraction of the excited population relaxes back to the Pfr state, while ~35% follows the forward reaction to the photoproduct. A combination of quantum mechanics/molecular mechanics calculations and ultrafast visible and infrared spectroscopies demonstrates how proton-coupled dynamics in the excited state of Pfr leads to a restructured hydrogen-bond environment of early Lumi-F, which is interpreted as a trigger for downstream protein structural changes.
Temporal disaggregation of hourly precipitation under changing climate over the Southeast United States
Authors: Takhellambam Bijoychandra S. , Srivastava Puneet , Lamba Jasmeet , McGehee Ryan P. , Kumar Hemendra , Tian Di 
Published: May 2022

AbstractClimate change impacts on precipitation characteristics will alter the hydrologic characteristics, such as peak flows, time to peak, and erosion potential of watersheds. However, many of the currently available climate change datasets are provided at temporal and spatial resolutions that are inadequate to quantify projected changes in hydrologic characteristics of a watershed. Therefore, it is critical to temporally disaggregate coarse-resolution precipitation data to finer resolutions for studies sensitive to precipitation characteristics. In this study, we generated novel 15-minute precipitation datasets from hourly precipitation datasets obtained from five NA-CORDEX downscaled climate models under RCP 8.5 scenario for the historical (1970–1999) and projected (2030–2059) years over the Southeast United States using a modified version of the stochastic method. The results showed conservation of mass of the precipitation inputs. Furthermore, the probability of zero precipitation, variance of precipitation, and maximum precipitation in the disaggregated data matched well with the observed precipitation characteristics. The generated 15-minute precipitation data can be used in all scientific studies that require precipitation data at that resolution.