bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of a tailored home-based exercise intervention during neoadjuvant chemotherapy in breast cancer patients
Authors: Sturgeon Kathleen M. , Smith Amanda M. , Federici Elizabeth H. , Kodali Namratha , Kessler Renée , Wyluda Edward , Cream Leah V. , Ky Bonnie , Schmitz Kathryn H. 
Published: February 2022

Abstract
Purpose
To evaluate the feasibility of a home-based moderate-to-vigorous intensity, phased (introduction, intermediate, maintenance), exercise prescription in breast cancer patients receiving cardiotoxic neoadjuvant chemotherapy.

Methods
Nineteen breast cancer patients were randomized to intervention or control for the duration of chemotherapy (16–24 weeks). The intervention was one aerobic exercise session at 80–90% VO2max for 25 min/week and 65%-75% VO2max for ≥ 50 min/week. Adherence to the tailored home-based program was assessed by heart rate monitors. Acceptability, tolerability, feasibility, efficacy, change in VO2max, and patient reported outcomes, safety, and clinical events were assessed.

Results
25.7% of eligible women consented (acceptability). Adherence was 87.6%. Women were not able to maintain exercise intensity as chemotherapy progressed (23.7% of exercise minutes were completed at prescribed heart rate during maintenance). Efficacy of the intervention was demonstrated by maintenance of VO2max (−1.0 ± 13.2%) compared to (−27.5 ± 7.4%) the control group. Further, during and after therapy, patients in the intervention arm reported less fatigue (control-baseline: 14.4 ± 15.9; midpoint: 19.0 ± 11.4; follow-up: 29.4 ± 20.0; intervention-baseline: 29.2 ± 24.6; midpoint: 24.6 ± 14.4; follow-up: 23.6 ± 11.9), impairment in activities (control-baseline: 13.7 ± 16.0; midpoint: 32.8 ± 17.0; follow-up: 58.6 ± 27.9; intervention-baseline: 38.7 ± 31.8; midpoint: 47.1 ± 27.5; follow-up: 47.5 ± 31.0), and pain (control-baseline: 80.8 ± 17.1; midpoint: 73.9 ± 20.7; follow-up: 50.7 ± 25.7; intervention-baseline: 68.7 ± 28.4; midpoint: 61.4 ± 22.5; follow-up: 65.3 ± 22.4). There were no differences in adverse events, treatment delays, or pathological complete response.

Conclusions
Neoadjuvant breast cancer patients maintained approximately one hour/week of moderate-intensity exercise over the course of their treatment. Further, this volume of exercise was sufficient to maintain fitness capacity and quality of life compared to the control group.
Trial registry: ClinicalTrials.gov Identifier: NCT03280836, prospectively registered 9/13/2017, https://clinicaltrials.gov/ct2/show/NCT03280836.
Sequential occurrence of recurrent Sweet syndrome and erythema nodosum without an underlying secondary cause: a case report
Authors: Mettananda Chamila , Peiris Hansika , Uwyse Ahamed 
Published: February 2022

Abstract
Background
Sweet syndrome is a rare cause of acute fever and painful erythematous skin plaques. Erythema nodosum is acute or chronic tender erythematous skin nodules of bilateral shins. The concurrent presence of both dermatoses is rare but reported in the literature. There are no reported cases of recurrent and sequential Sweet syndrome and erythema nodosum without an underlying secondary cause.

Case presentation
We report the case of a 64-year-old Asian woman, who had possible Sweet syndrome 12 years ago and biopsy-proven erythema nodosum 5 years ago, presenting with an acute episode of Sweet syndrome. Extensive investigations did not reveal any underlying secondary cause.

Conclusions
Recurrent Sweet syndrome and sequential presence with erythema nodosum raises suspicion if Sweet syndrome and erythema nodosum are different presentations of one disease, which warrants further study. This case proves that recurrent Sweet syndrome and erythema nodosum can occur in healthy individuals without an underlying malignancy or secondary cause.
The dual role of p62 in ferroptosis of glioblastoma according to p53 status
Authors: Yuan Fanen , Sun Qian , Zhang Si , Ye Liguo , Xu Yang , Deng Gang , Xu Zhou , Zhang Shenqi , Liu Baohui , Chen Qianxue 
Published: February 2022

Abstract
Background
Ferroptosis plays a key role in human cancer, but its function and mechanism in glioma is not clear. P62/SQSTM1 was reported to inhibit ferroptosis via the activation of NRF2 signaling pathway. In this study we reveal a dual role of p62 in ferroptosis of glioblastoma (GBM) according to p53 status.

Method
Lipid peroxidation analysis, transmission electron microscopy (TEM), GSH assay were performed to determine the level of ferroptosis. Western blot and qPCR were obtained to detect the expression of ferroptosis markers. Construction of mutant plasmids, immunoprecipitation, luciferase assay and rescue-experiments were performed to explore the regulatory mechanism.

Results
P62 overexpression facilitates ferroptosis and inhibits SLC7A11 expression in p53 mutant GBM, while attenuates ferroptosis and promotes SLC7A11 expression in p53 wild-type GBM. P62 associates with p53 and inhibits its ubiquitination. The p53-NRF2 association and p53-mediated suppression of NRF2 antioxidant activity are diversely regulated by p62 according to p53 status. P53 mutation status is required for the dual regulation of p62 on ferroptosis. In wild-type p53 GBM, the classical p62-mediated NRF2 activation pathway plays a major regulatory role of ferroptosis, leading to increased SLC7A11 expression, resulting in a anti-ferroptosis role. In mutant p53 GBM, stronger interaction of mutant-p53/NRF2 by p62 enhance the inhibitory effect of mutant p53 on NRF2 signaling, which reversing the classical p62-mediated NRF2 activation pathway, together with increased p53’s transcriptional suppression on SLC7A11 by p62, leading to a decrease of SLC7A11, resulting in a pro-ferroptosis role.

Conclusion
Together, this study shows novel molecular mechanisms of ferroptosis regulated by p62; the mutation status of p53 is an important factor that determines the therapeutic response to p62-mediated ferroptosis-targeted therapies in GBM.
Partial asymptotic stability of neutral pantograph stochastic differential equations with Markovian switching
Authors: Mchiri Lassaad , Caraballo Tomás , Rhaima Mohamed 
Published: February 2022

AbstractIn this paper, we investigate the partial asymptotic stability (PAS) of neutral pantograph stochastic differential equations with Markovian switching (NPSDEwMSs). The main tools used to show the results are the Lyapunov method and the stochastic calculus techniques. We discuss a numerical example to illustrate our main results.
Absolute versus relative socioeconomic disadvantage and homicide: a spatial ecological case–control study of US zip codes
Authors: Gobaud Ariana N. , Mehranbod Christina A. , Dong Beidi , Dodington James , Morrison Christopher N. 
Published: February 2022

Abstract
Background
Homicide is a major cause of death and contributes to health disparities in the United States. This burden overwhelmingly affects people from racial and ethnic minority populations as homicide occurs more often in neighborhoods with high proportions of racial and ethnic minority residents. Research has identified that environmental factors contribute to variation in homicide rates between neighborhoods; however, it is not clear why some neighborhoods with high concentrations of racial and ethnic minority residents have high homicide rates while neighborhoods with similar demographic compositions do not. The aim of this study was to assess whether relative socioeconomic disadvantage, (i.e., income inequality), or absolute socioeconomic disadvantage (i.e., income) measured at the ZIP code- and state-levels, is associated with high homicide rates in US ZIP codes, independent of racial and ethnic composition.

Methods
This ecological case–control study compared median household income and income inequality in 250 ZIP codes with the highest homicide rate in our sample in 2017 (cases) to 250 ZIP codes that did not experience any homicide deaths in 2017 (controls). Cases were matched to controls 1:1 based on demographic composition. Variables were measured at both the ZIP code- and state-levels.

Results
Lower median household income at the ZIP code-level contributed most substantially to the homicide rate. Income inequality at the state-level, however, was additionally significant when controlling for both ZIP code- and state-level factors.

Conclusions
Area-based interventions that improve absolute measures of ZIP code socioeconomic disadvantage may reduce gaps in homicide rates.
Assessing vulnerability and adaptation strategy of the cyclone affected coastal area of Bangladesh
Authors: Rahman Md. Mizanoor , Hossain Md. Alamgir , Ali Md. Rayhan , Ahmed Zihad , Hedayutul Islam A. H. M. 
Published: February 2022

AbstractBangladesh is a land of natural calamities. Due to locational disadvantages, especially being situated at the tip of the funnel-shaped Bay of Bengal on the south and at the foot of Himalayas on the north, every year it experiences a number of different types of natural calamities, such as flood, cyclone, river bank erosion, drought etc. As a result of climate change events, an increasing trend in frequency has been observed in recent time. Spatial distribution of natural calamities portraits northern part as prone to flood, western part to drought, eastern part (basically hilly region) to flash flood and southern part to cyclone. The Southern part, especially the coastal belt of the country is the worst affected area to cyclones and their ultimate effects. Among these cyclones, Aila was a severe one that tore through the area in 2009 affecting the livelihood of the inhabitants. This study is an effort to discuss the inhabitants’ vulnerability and their adaptation strategies to economic changes caused by Aila, such as occupation, income, expenditure capacity, savings, housing structures, general and agricultural land use etc. For the study required data has been collected from both primary and secondary sources. Primary data have been collected through questionnaire survey and group discussion while secondary data, especially satellite images have been collected from Google Earth. Then different softwares like SPSS have been used for analysis and graphic presentation of the collected primary data, and ERDAS IMAGINE and ArcGIS have been used for mapping analysis and presentation. The research findings indicate that because of the cyclone Aila, economy of the area has taken downturn. Most of the people were engaged in agriculture allied activities, but after Aila, agricultural land had been converted into aquaculture. Consequently, people have switched to occupations with lesser earnings, such as daily labour, rickshaw puller, brick field worker etc. As a result, people had to reduce all sorts of daily consumptions to cope up with the changing situation. The Governmental Organisations and the Non-Governmental Organisations extended little help to rebuild houses, embankment, road, reforestation etc. but not towards any income generates activities. So, the livelihood of the people is still vulnerable in terms of economy, and attention of the responsible authorities needs to be drawn to create income generating activities to recover the vulnerable situation in the study area.
Association of CAPN10 haplotype combinations with type 2 diabetes mellitus and metabolic syndrome among Egyptians: pilot study—genotyping of three CAPN10 variants
Authors: El-Far Shaymaa W. , Kassem Heba Sh. , Embaby Amira M. , Saad Abir A. , Mowafy Nader , Haroun Medhat 
Published: February 2022

Abstract
Background
T2DM is a polygenic, metabolic complex and multifactorial disease. Several genes contribute to risk of type 2 diabetes and metabolic syndrome among different populations.

Results
An relationship between three identified CAPN-10 variants [SNP-43 (rs#3792267), SNP-19 (rs#3842570) and SNP-63 (rs#5030952)] localized on 2q37 and type 2 diabetic patients with and without metabolic syndrome (MS) have been reported in our comparative study (diabetic vs health control individuals). Genotyping of study cohorts was carried out using restriction fragment length polymorphism (RFLP-PCR). Statistical analysis of data reveals that the haplotype combination 111/112 confers a significant risk for type 2 diabetes mellitus (T2DM). Patients with the homozygous haplotype combination of 122/122 are less susceptible to MS when compared to other patients carrying other haplotype combinations. Regarding obesity, a core component in MS, the haplotype combinations 111/121 and 122/122 demonstrate a significant protective role. Furthermore, the haplotype combination 111/111 displays a significant risk for high levels of total cholesterol.

Conclusion
Present findings address that these haplotype combinations 111/112, 111/121 and 122/122 of CAPN-10 SNP-43, -19 and -63 constitute unique DNA biomarker fingerprints toward susceptibility and risk for T2DM and MS among Egyptians when compared to other haplotype combinations reported in other populations of different ethnicity. To enhance the power of human evolution control nowadays, mutations and polymorphisms in target genes associated with human diseases should be well understood.
Importance of Cytopathologic Diagnosis in Early Cancer Diagnosis in Resource-Constrained Countries
Authors: Yadav Kavita , Cree Ian , Field Andrew , Vielh Philippe , Mehrotra Ravi 
Published: February 2022

PURPOSE The rising cancer burden in low- and middle-income countries (LMICs) stresses already weak health care systems and poses unique challenges. In resource-constrained LMICs and in circumstances where most patients must pay out of pocket for diagnostic tests, these may not be available or affordable for many. Cytopathology provides a simple, inexpensive, standardized, and low-technology diagnostic procedure that is increasingly used as an effective tool to address the hurdles faced in cancer control programs in LMICs. This review explores the potential role of cytopathology in LMICs in reducing the cancer burden. METHODS This review studied the existing literature across the globe regarding the utilization of cytopathology as a diagnostic or screening tool for various types of malignancies as well as its advantages and disadvantages, depending on the local situation. RESULTS Apart from the usefulness of cytopathology, this review also sheds light on the barriers to using cytopathology in LMICs. Most recently, SARS-CoV-2 has produced several unique challenges for cytopathology. These are being met with innovative measures to combat the effects of the pandemic and ensure the safe delivery of essential cytopathology services. CONCLUSION The usefulness of cytopathologic techniques has been demonstrated via various studies, even during the recent pandemic. If cytology is to be used appropriately, the focus needs to be on integrating it into the national cancer screening and diagnostic programs as well as providing well-trained human resources.
Chirped elliptic waves: Coupled Helmholtz equations
Authors: Saha Naresh , Roy Barnana , Khare Avinash 
Published: February 2022

Abstract
Exact chirped elliptic wave solutions are obtained within the framework of coupled cubic nonlinear Helmholtz equations in the presence of non-Kerr nonlinearity like self-steepening and self-frequency shift. It is shown that, for a particular combination of the self-steepening and the self-frequency shift parameters, the associated nontrivial phase gives rise to chirp reversal across the solitary wave profile. But a different combination of non-Kerr terms leads to chirping but no chirp reversal. The effect of nonparaxial parameter on physical quantities such as intensity, speed and pulse width of the elliptic waves is studied too. It is found that the speed of the solitary wave can be tuned by altering the nonparaxial parameter. Stable propagation of these nonparaxial elliptic waves is achieved by an appropriate choice of parameters.
Sex-specific Association of Subclinical Hypothyroidism With Incident Metabolic Syndrome: A Population-based Cohort Study
Authors: Wu Zhiyuan , Jiang Yue , Zhou Di , Chen Shuo , Zhao Yu , Zhang Haiping , Liu Yue , Li Xia , Wang Wei , Zhang Jingbo , Kang Xiaoping , Tao Lixin , Gao Bo , Guo Xiuhua 
Published: February 2022

Abstract

Objective
Subclinical hypothyroidism is known to increase the risk of cardiovascular diseases and mortality. However, the longitudinal association between subclinical hypothyroidism and incident metabolic syndrome remains unclear.

Methods
A total of 3615 participants from Beijing Health Management Cohort were enrolled from 2012 to 2014 and followed through 2019. People were placed into subclinical hypothyroidism and euthyroidism groups according to serum-free thyroxine and TSH concentrations. We used Cox proportional hazards regression models to investigate the relationship between TSH level and incident metabolic syndrome considering the modification effect of sex and age.

Results
Of 3615 participants, 1929 were men (53.4%); mean (SD) age was 43.51 (11.73) years. Throughout the follow-up (median [interquartile range], 3.0 [2.8-3.2] years), 738 individuals developed metabolic syndrome. Subclinical hypothyroidism was significantly associated with metabolic syndrome development only in men, and the adjusted hazard ratio was 1.87 (95% CI, 1.21-2.90) compared with euthyroidism group. Of note, there was no increased risk of metabolic syndrome in people aged 50 years or older with subclinical hypothyroidism.

Conclusions
Subclinical hypothyroidism is associated with incident metabolic syndrome in young men. Further studies are needed to evaluate the targeted threshold and benefit of thyroid hormone replacement therapy for metabolic health.
Sanitizing Philosophical Love
Authors: Denton Chad S. 
Published: February 2022

AbstractEven though Enlightenment philosophes often drew on relativistic comparisons among societies and historical eras to legitimize their ideas for reform, most would not argue for extending social tolerance of same-sex love, even when faced with historical trends such as Greek pederasty. Although in the seventeenth and eighteenth centuries French classicists and historians did more to challenge established interpretations and narratives, they still sought to construct a rational foundation for denying the historical reality for legitimized sodomy or to draw arguments for chaste pederasty from ancient sources. Examining early modern French translations of Aristophanes and Plato's Symposium, as well as detailed historical narratives of ancient Greece from 1650 to 1789, this essay argues that scholarly treatments of Greek pederasty reflected broader shifts in attitudes toward sodomy.Les philosophes des Lumières ont souvent invoqué les comparaisons relativistes entre différentes sociétés et époques historiques afin de légitimer leurs idées de réforme. Cependant, malgré leur connaissance des exemples comme la pédérastie grecque, ils n'ont pas adopté la tolérance sociale pour l'amour homosexuel. Bien que les savants et les historiens du XVIIe au XVIIIe siècle aient fait un grand travail de réinterprétation de l'antiquité, ils s'efforçaient quand même soit à nier l'existence d'une sodomie légitimée par les usages de la société grecque, soit à évoquer une pédérastie chaste dans les sources anciennes. En examinant les traductions françaises d'Aristophane et du « Banquet » de Platon et les œuvres historiques sur la Grèce antique parues entre 1650 et 1789, cet essai montre que les interprétations savantes de la pédérastie grecque reflétaient les mentalités de l’époque moderne vis-à-vis de la sodomie.
Archives, Memories, and Masks in Writing the History of the French Resistance
Authors: Jackson Julian 
Published: February 2022

AbstractThis article uses the writings of the famous resister-turned-historian Daniel Cordier as a prism through which to examine how witnesses and historians have approached the history of the French Resistance since 1945. Cordier, having served as Jean Moulin's secretary in the war, later became his biographer. His neopositivist approach prioritized the use of written archives over memories. Since Cordier himself later wrote his own memoirs, the article examines the problems with this autobiographical text. Examining Cordier's reticence about discussing his own homosexuality, it suggests that between the lines of his memoir one can envisage the possibility one day of writing an emotional history of the Resistance.Cet article prend les écrits du célèbre résistant-historien Daniel Cordier comme un prisme pour analyser comment témoins et historiens ont abordé l'histoire de la Résistance depuis 1945. Ayant servi comme secrétaire à Jean Moulin pendant la guerre, Cordier devient trente ans après son biographe, prônant une démarche résolument néo-positiviste qui privilégie les archives écrites sur les témoignages. Ensuite Cordier lui-même livre son propre témoignage dans son livre Alias Caracalla. Examinant quelques problèmes soulevés par ce texte autobiographique, dont la réticence de Cordier à aborder le sujet de sa propre homosexualité, on perçoit entre les lignes de ses mémoires des pistes pour une future histoire émotionnelle (et sexuelle) de la Résistance.
Proust, Typical Novelist: Literary Context as Type
Authors: Ossa-Richardson Anthony 
Published: February 2022

Abstract
A decade ago Rita Felski argued that reliance on context shuts down a text’s meaning by enclosing it in a restrictive historical “box” and alienating its individuality. This essay offers a rebuttal to Felski’s critique, first by delineating the genealogy of her concerns in literary, philosophical, and architectural thought of the late nineteenth century, and second by exploring an alternative model of context as type, as revealed by a close reading of Marcel Proust’s À la recherche du temps perdu. Proust’s novel repeatedly makes use of a notion of the type (a person, an artwork, a battle) that prioritizes the act of typifying, an act that does not sacrifice but discloses, or even constitutes, the individual. Like the Proustian type, context is best understood not as an alienation from, but as a route to, the particularity of the literary object.
Les Femmes dans la querelle de la moralité du théâtre
Authors: Scotto di Clemente Clément 
Published: February 2022

Abstract
Au sein des polémiques théâtrales du XVIIe siècle, le traité de Mademoiselle de Beaulieu tient lieu de modèle et d’exception. En fondant son argumentation sur un détournement des topiques théâtrophobes, qui promeut une réforme esthétique et économique de la scène, son texte est emblématique des stratégies apologétiques au sein des querelles sur le théâtre. Il se singularise cependant par l’éloge fait à Isabella Andreini, qui relève autant de la provocation sur le comédien idolâtre que de la promotion d’une actrice politique. La querelle du théâtre ainsi engagée croise les enjeux esthétiques, politiques et religieux, dans un contexte de guerre des religions et de changement de pouvoir. Mlle de Beaulieu en use pour servir trois femmes et trois causes : elle-même et la place des femmes dans le champ des lettres ; Andreini et l’art théâtral italien ; Marie de Médicis, son mécénat et sa politique.