bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pivotal Response Treatment (PRT) parent group training for young children with autism spectrum disorder: a pilot study
Authors: de Korte Manon W. P. , van Dongen‑Boomsma Martine , Oosterling Iris J. , Buitelaar Jan. K. , Staal Wouter G. 
Published: May 2022

AbstractPivotal Response Treatment (PRT) is a promising intervention addressing core symptoms of autism spectrum disorder (ASD), with parent involvement as key component. Parent group-delivered PRT may be an effective treatment model, but currently the evidence is limited. Also, little attention has been paid to therapeutic involvement of multiple important contexts (e.g. home, school, community) of the young child. The current study explores a 14-week protocol of PRT parent group training (PRT-PG), complemented with individual parent–child sessions and involvement of teachers and other childcare providers. Children aged 2–6 years old with ASD and their parents (n = 20) were included. Preliminary results showed a significant increase in spontaneous initiations during a semi-structured therapist-child interaction together with widespread gains in clinical global functioning. No significant improvement on parent-rated general social-communication skills was observed. These findings justify further research on parent group delivered PRT models.
Quantum pixel representations and compression for N-dimensional images
Authors: Amankwah Mercy G. , Camps Daan , Bethel E. Wes , Van Beeumen Roel , Perciano Talita 
Published: May 2022

AbstractWe introduce a novel and uniform framework for quantum pixel representations that overarches many of the most popular representations proposed in the recent literature, such as (I)FRQI, (I)NEQR, MCRQI, and (I)NCQI. The proposed QPIXL framework results in more efficient circuit implementations and significantly reduces the gate complexity for all considered quantum pixel representations. Our method scales linearly in the number of pixels and does not use ancilla qubits. Furthermore, the circuits only consist of $$R_y$$

R
y

gates and $$\text {CNOT}$$
CNOT
gates making them practical in the NISQ era. Additionally, we propose a circuit and image compression algorithm that is shown to be highly effective, being able to reduce the necessary gates to prepare an FRQI state for example scientific images by up to 90% without sacrificing image quality. Our algorithms are made publicly available as part of , a Quantum Image Pixel Library.
On the net primary productivity over the Arabian Sea due to the reduction in mineral dust deposition
Authors: Tandule Chakradhar Rao , Gogoi Mukunda M. , Kotalo Rama Gopal , Babu S. Suresh 
Published: May 2022

AbstractThe dust plume tracks from the Middle East and Eastern Africa to the Indian subcontinent have an impact on the atmospheric and ocean biogeochemistry of the Arabian Sea (AS). Here, we present the impact of dust on net primary productivity (NPP) over the AS using satellite-based observation and model simulation. Seasonal episodes and long-term trends in dust optical depth (DOD), dust mass flux (DMF) and dust deposition flux (DDF) from 2007 to 2020 are quantified. Nearly 32% of the total dust is advected to the AS during transport (maximum in JJA; DMF ~ 33.1 Tg year−1 ~ 56% of annual and DDF ~ 5.5 Tg year−1 ~ 63% of annual). Over the last one and half decades, there has been a statistically significant decreasing trend in DOD, associated with precipitation, enhanced vegetation index and surface soil moisture over the landmasses in the proximity of the AS. Similarly, the depletion in DDF suppresses the NPP over different regions of the AS, especially over the central AS, where the oceanic supply of nutrients is limited.
First fluvial archive of the 8.2 and 7.6–7.3 ka events in North Africa (Charef River, High Plateaus, NE Morocco)
Authors: Depreux Bruno , Berger Jean-François , Lefèvre David , Wackenheim Quentin , Andrieu-Ponel Valérie , Vinai Sylvia , Degeai Jean-Philippe , El Harradji Abderrahmane , Boudad Larbi , Sanz-Laliberté Séverine , Michel Kristell , Limondin-Lozouet Nicole 
Published: May 2022

AbstractThe Early–Mid Holocene transition is a period of profound changes in climatic mechanisms and hydrological features in Europe and North Africa. The melting of the Laurentide ice sheet led to an oceanic and atmospheric reorganisation in the North Atlantic, while the Mediterranean underwent a major hydrological shift. The impacts on Mediterranean rivers remain unclear, as there are few records documenting responses to the 8.2 ka event (the main Holocene climatic degradation). We present a fluvial record from Eastern Morocco documenting detailed hydrological variations from 8200 to 7500 cal. BP and their climatic forcing. A major hydrogeomorphic evolution of the Charef River occurred at that time, marked by two major incision stages close in time, under hyper-arid conditions at 8200 and ca. 7500 cal. BP. The impacts of these phenomena on the alluvial plains and associated archaeological records during Neolithisation, a major process in human history, currently remain unidentified. This new record sheds light on the fluvial response to the 8.2 ka event in North Africa and why other records are missing. We also bring new insights into the hydrological disruption at the Early–Mid Holocene transition, which was driven by the end of deglaciation combined with insolation and solar forcing. Furthermore, centennial solar variability may have paced river activity in the Moulouya basin and arid regions of North Africa.
The feasibility to use artificial intelligence to aid detecting focal liver lesions in real-time ultrasound: a preliminary study based on videos
Authors: Tiyarattanachai Thodsawit , Apiparakoon Terapap , Marukatat Sanparith , Sukcharoen Sasima , Yimsawad Sirinda , Chaichuen Oracha , Bhumiwat Siwat , Tanpowpong Natthaporn , Pinjaroen Nutcha , Rerknimitr Rungsun , Chaiteerakij Roongruedee 
Published: May 2022

AbstractDespite the wide availability of ultrasound machines for hepatocellular carcinoma surveillance, an inadequate number of expert radiologists performing ultrasounds in remote areas remains a primary barrier for surveillance. We demonstrated feasibility of artificial intelligence (AI) to aid in the detection of focal liver lesions (FLLs) during ultrasound. An AI system for FLL detection in ultrasound videos was developed. Data in this study were prospectively collected at a university hospital. We applied a two-step training strategy for developing the AI system by using a large collection of ultrasound snapshot images and frames from full-length ultrasound videos. Detection performance of the AI system was evaluated and then compared to detection performance by 25 physicians including 16 non-radiologist physicians and 9 radiologists. Our dataset contained 446 videos (273 videos with 387 FLLs and 173 videos without FLLs) from 334 patients. The videos yielded 172,035 frames with FLLs and 1,427,595 frames without FLLs for training on the AI system. The AI system achieved an overall detection rate of 89.8% (95%CI: 84.5–95.0) which was significantly higher than that achieved by non-radiologist physicians (29.1%, 95%CI: 21.2–37.0,p < 0.001) and radiologists (70.9%, 95%CI: 63.0–78.8,p < 0.001). Median false positive detection rate by the AI system was 0.7% (IQR: 1.3%). AI system operation speed reached 30–34 frames per second, showing real-time feasibility. A further study to demonstrate whether the AI system can assist operators during ultrasound examinations is warranted.
Quantifying firm-level economic systemic risk from nation-wide supply networks
Authors: Diem Christian , Borsos András , Reisch Tobias , Kertész János , Thurner Stefan 
Published: May 2022

AbstractCrises like COVID-19 exposed the fragility of highly interdependent corporate supply networks and the complex production processes depending on them. However, a quantitative assessment of individual companies’ impact on the networks’ overall production is hitherto non-existent. Based on a unique value added tax dataset, we construct the firm-level production network of an entire country at an unprecedented granularity and present a novel approach for computing the economic systemic risk (ESR) of all firms within the network. We demonstrate that 0.035% of companies have extraordinarily high ESR, impacting about 23% of the national economic production should any of them default. Firm size cannot explain the ESR of individual companies; their position in the production networks matters substantially. A reliable assessment of ESR seems impossible with aggregated data traditionally used in Input-Output Economics. Our findings indicate that ESR of some extremely risky companies can be reduced by introducing supply chain redundancies and changes in the network topology.
Neurophysiological effects of human-derived pathological tau conformers in the APPKM670/671NL.PS1/L166P amyloid mouse model of Alzheimer’s disease
Authors: Tok S. , Maurin H. , Delay C. , Crauwels D. , Manyakov N. V. , Van Der Elst W. , Moechars D. , Drinkenburg W. H. I. M. 
Published: May 2022

AbstractAlzheimer’s Disease (AD) is a neurodegenerative disease characterized by two main pathological hallmarks: amyloid plaques and intracellular tau neurofibrillary tangles. However, a majority of studies focus on the individual pathologies and seldom on the interaction between the two pathologies. Herein, we present the longitudinal neuropathological and neurophysiological effects of a combined amyloid-tau model by hippocampal seeding of human-derived tau pathology in the APP.PS1/L166P amyloid animal model. We statistically assessed both neurophysiological and pathological changes using linear mixed modelling to determine if factors such as the age at which animals were seeded, genotype, seeding or buffer, brain region where pathology was quantified, and time-post injection differentially affect these outcomes. We report that AT8-positive tau pathology progressively develops and is facilitated by the amount of amyloid pathology present at the time of injection. The amount of AT8-positive tau pathology was influenced by the interaction of age at which the animal was injected, genotype, and time after injection. Baseline pathology-related power spectra and Higuchi Fractal Dimension (HFD) score alterations were noted in APP.PS1/L166P before any manipulations were performed, indicating a baseline difference associated with genotype. We also report immediate localized hippocampal dysfunction in the electroencephalography (EEG) power spectra associated with tau seeding which returned to comparable levels at 1 month-post-injection. Longitudinal effects of seeding indicated that tau-seeded wild-type mice showed an increase in gamma power earlier than buffer control comparisons which was influenced by the age at which the animal was injected. A reduction of hippocampal broadband power spectra was noted in tau-seeded wild-type mice, but absent in APP.PS1 animals. HFD scores appeared to detect subtle effects associated with tau seeding in APP.PS1 animals, which was differentially influenced by genotype. Notably, while tau histopathological changes were present, a lack of overt longitudinal electrophysiological alterations was noted, particularly in APP.PS1 animals that feature both pathologies after seeding, reiterating and underscoring the difficulty and complexity associated with elucidating physiologically relevant and translatable biomarkers of Alzheimer’s Disease at the early stages of the disease.
On the relationship between mind wandering and mindfulness
Authors: Belardi Angelo , Chaieb Leila , Rey-Mermet Alodie , Mormann Florian , Rothen Nicolas , Fell Juergen , Reber Thomas P. 
Published: May 2022

AbstractMind wandering (MW) and mindfulness have both been reported to be vital moderators of psychological wellbeing. Here, we aim to examine how closely associated these phenomena are and evaluate the psychometrics of measures often used to quantify them. We investigated two samples, one consisting of German-speaking unpaid participants (GUP, n $$=$$
=
313) and one of English-speaking paid participants (EPP, n $$=$$
=
228) recruited through MTurk.com. In an online experiment, we collected data using the Mindful Attention Awareness Scale (MAAS) and the sustained attention to response task (SART) during which self-reports of MW and meta-awareness of MW were recorded using experience sampling (ES) probes. Internal consistency of the MAAS was high (Cronbachs $$\alpha$$
α
of 0.96 in EPP and 0.88 in GUP). Split-half reliability for SART measures and self-reported MW was overall good with the exception of SART measures focusing on Nogo trials, and those restricted to SART trials preceding ES in a 10 s time window. We found a moderate negative association between trait mindfulness and MW as measured with ES probes in GUP, but not in EPP. Our results suggest that MW and mindfulness are on opposite sides of a spectrum of how attention is focused on the present moment and the task at hand.
Development of a predictive model for luteal phase oocyte retrieval in poor responders undergoing natural cycle IVF
Authors: Simopoulou Mara , Galatis Dionysios , Maziotis Evangelos , Pantou Agni , Giannelou Polina , Grigoriadis Sokratis , Tzonis Panagiotis , Griva Theodora , Zikopoulos Athanasios , Philippou Anastasios , Koutsilieris Michael , Pantos Konstantinos , Sfakianoudis Konstantinos 
Published: May 2022

AbstractThe aim of this study is the development of a prediction model indicating successful application of Oocyte Retrieval performed during the Luteal Phase (LuPOR) in poor responders, as defined by the retrieval of at least one MII oocyte. Recruitment included 1688 poor responders diagnosed as per Bologna Criteria, undergoing natural cycle ICSI between 2012 and 2020. Oocyte collections were performed during the follicular phase and during the luteal phase similarly. Antral Follicle Count (AFC), Estradiol (E2) levels evaluated on both trigger days prior to Follicular Phase Oocyte Retrieval (FoPOR) and LuPOR, and the number of small follicles 8–12 mm that were not aspirated during FoPOR were identified as predictive factors indicative of an efficient LuPOR practice with an Area Under the Curve (AUC) of 0.86, 0.86, 0.89 as well as 0.82 respectively. The combination of the above-mentioned characteristics into a prediction model provided an AUC of 0.88, specificity and a sensitivity of 0.73 and 0.94 respectively and an accuracy of 0.89. The model provided a positive predictive value (PPV) of 93.5% and a negative predictive value (NPV) of 46.8%. The clinical conclusion of the present study aims to be of added value to the clinician, by providing a prediction model defining the POR population benefiting from LuPOR. The high PPV of this model may renders this tool helpful for the practitioner that considers LuPOR.
Expanding the use of ethanol as a feedstock for cell-free synthetic biochemistry by implementing acetyl-CoA and ATP generating pathways
Authors: Liu Hongjiang , Arbing Mark A. , Bowie James U. 
Published: May 2022

AbstractEthanol is a widely available carbon compound that can be increasingly produced with a net negative carbon balance. Carbon-negative ethanol might therefore provide a feedstock for building a wider range of sustainable chemicals. Here we show how ethanol can be converted with a cell free system into acetyl-CoA, a central precursor for myriad biochemicals, and how we can use the energy stored in ethanol to generate ATP, another key molecule important for powering biochemical pathways. The ATP generator produces acetone as a value-added side product. Our ATP generator reached titers of 27 ± 6 mM ATP and 59 ± 15 mM acetone with maximum ATP synthesis rate of 2.8 ± 0.6 mM/h and acetone of 7.8 ± 0.8 mM/h. We illustrated how the ATP generating module can power cell-free biochemical pathways by converting mevalonate into isoprenol at a titer of 12.5 ± 0.8 mM and a maximum productivity of 1.0 ± 0.05 mM/h. These proof-of-principle demonstrations may ultimately find their way to the manufacture of diverse chemicals from ethanol and other simple carbon compounds.
Evaluation of protein production in rice seedlings under dark conditions
Authors: Watanabe Akiko , Hatanaka Yoshino , Takeshima Yukino , Sasaki Karin , Takahashi Noa , Ito Yukihiro 
Published: May 2022

AbstractAlthough plants have several advantages for foreign protein production, cultivation of transgenic plants in artificial plant growth facilities involves the use of a great amount of electricity for lightning and air conditioning, reducing cost-effectiveness. Protein production in plants grown in darkness can overcome this problem, but the amount of protein produced in the dark is unknown. In this study, the total amount of soluble protein produced in rice seedlings germinated and grown in light or darkness were examined at several time points after germination and under different temperature, nutritional, and seedling density conditions. Our results indicate that rice seedlings grown in darkness produce a comparable amount of total soluble protein to those grown in light. Furthermore, we found that the best conditions for protein production in dark-grown rice seedlings are large seeds germinated and grown for 10–12 days at 28 °C supplemented with Murashige and Skoog medium and 30 g/l sucrose in dense planting. Therefore, our results suggest that foreign proteins can be produced in rice seedlings in the dark, with a reduced electricity use and an increase in cost-effectiveness.
Three-dimensional shape and deformation measurement on complex structure parts
Authors: Wu Zhoujie , Guo Wenbo , Chen Zhengdong , Wang Haoran , Li Xunren , Zhang Qican 
Published: May 2022

AbstractStereo digital image correlation technique (stereo-DIC or 3D-DIC) has been widely used in three-dimensional (3D) shape and deformation measurement due to its high accuracy and flexibility. But it is a tough task for it to deal with complex structure components because of the severe perspective distortion in two views. This paper seeks to resolve this issue using a single-camera system based on DIC-assisted fringe projection profilometry (FPP). A pixel-wise and complete 3D geometry of complex structures can be reconstructed using the robust and efficient Gray-coded method based on a FPP system. And then, DIC is just used to perform the temporal matching and complete full-field pixel-to-pixel tracking. The in- and out-of-plane deformation are obtained at the same time by directly comparing the accurate and complete 3D data of each corresponding pixel. Speckle pattern design and fringe denoising methods are carefully compared and chosen to simultaneously guarantee the measuring accuracy of 3D shape and deformation. Experimental results demonstrate the proposed method is an effective means to achieve full-field 3D shape and deformation measurement on complex parts, such as honeycomb structure and braided composite tube, which are challenging and even impossible for the traditional stereo-DIC method.
Microwave treatment of rice bran and its effect on phytochemical content and antioxidant activity
Authors: Pokkanta Piramon , Yuenyong Jitkunya , Mahatheeranont Sugunya , Jiamyangyuen Sudarat , Sookwong Phumon 
Published: May 2022

AbstractAn alternative approach for rice bran stabilization is microwave treatment. However, the effects of the microwave treatment on the contents of bioactive compounds and antioxidant activities of the rice bran have rarely been reported in detail. In this study, microwave pretreatment (130–880 W for 0.5–5.0 min) of rice bran was proposed where the antioxidant activity, total flavonoids, and total phenolic contents were determined using UV–Vis spectrometry. Tocols, γ-oryzanols, squalene, phytosterols and phenolic compounds were quantified using high-performance liquid chromatography. The results showed an increase in the antioxidant activity (0.5 folds), total phenolic contents (1.3 folds), total flavonoid contents (0.9 folds), total tocols (2.6 folds), total γ-oryzanols (1.6 folds), and total phytosterols (1.4 folds). Phytochemicals were enhanced, especially trans-p-coumaric acid (10.3 folds) and kaempferol (8.6 folds). The microwave treatment at 440 W for 2.5 min provided the best contents of the bioactive compounds and antioxidant activity. This work revealed the microwave treatment as a potential tool for stabilizing rice bran and increasing the usability of its phytochemicals, which applies to several industries concerning the use of rice bran as an ingredient.
Temporary cable force monitoring techniques during bridge construction-phase: the Tajo River Viaduct experience
Authors: Gaute-Alonso Alvaro , Garcia-Sanchez David , Alonso-Cobo Carlos , Calderon-Uriszar-Aldaca Iñigo 
Published: May 2022

AbstractThis article deals with the comparative analysis of current cable force monitoring techniques. In addition, the experience of three cable stress monitoring techniques during the construction phase is included: (a) the installation of load cells on the active anchorages of the cables, (b) the installation of unidirectional strain gauges, and (c) the evaluation of stresses in cables applying the vibrating wire technique by means of the installation of accelerometers. The main advantages and disadvantages of each technique analysed are highlighted in the Construction Process context of the Tajo Viaduct, one of the most singular viaducts recently built in Spain.
Simple, fast and reliable CE method for simultaneous determination of ciprofloxacin and ofloxacin in human urine
Authors: Kośka Izabella , Purgat Krystian , Kubalczyk Paweł 
Published: May 2022

AbstractA simple, fast, and accurate capillary zone electrophoresis method has been developed for the determination of ciprofloxacin and ofloxacin. This method uses liquid–liquid extraction. Therefore, it is characterized by a very simple procedure of sample preparation but at the same time satisfactory precision and accuracy. The extraction process of the same urine sample was repeated three times. The extraction protocol was performed each time for 15 min with 1 mL of dichloromethane and chloroform mixture in a 3:1 volume ratio. A 0.1 mol/L phosphate-borate buffer (pH 8.40) was selected as the background electrolyte. UV detection was performed at 288 nm. The separation was carried out at a voltage of 16 kV, at a temperature of 25 °C. Experimentally evaluated LOQ values for ciprofloxacin and ofloxacin were 0.2 nmol/mL urine and 0.05 nmol/mL urine, respectively. For both analytes the calibration curves exhibited linearity over the entire tested concentration range of 1–6 nmol/mL urine. The precision of the method did not exceed 15%, and the recovery was in the range of 85–115%. The developed and validated procedure was applied to analyze human urine for the content of ciprofloxacin and ofloxacin.