bluuebunny/crossref_metadata_2025_split huggingface dataset:
Erken dönem civciv embriyo modelinde dimenhidrinatın nöral tüp gelişimi üzerine etkisi
Authors: SARITAŞ Alperen , ALBAŞ KURT Gülan , BİLİR Abdülkadir , TURAMANLAR Ozan , GÜRSOY Fatih 
Published: December 2022

Amaç: Bu çalışmada dimenhidrinat’ın erken dönem civciv embriyo modelinde nöral tüp gelişimi üzerindeki etkilerinin araştırılması amaçlanmıştır.
Gereç ve Yöntem: Çalışmada 32 fertil, spesifik patojen olmayan yumurta kullanıldı. Tüm yumurtalar her bir grupta 8 adet olacak şekilde dört gruba ayrıldı. İnkübasyonun 28. saatinde deney gruplarına üç farklı dozda (0,7, 1,4, 2,1 mg/kg) dimenhidrinat ve kontrol grubuna serum fizyolojik enjekte edildi. İnkübasyonun 48. saatinde tüm embriyolar diseke edildi ve ışık mikroskobu altında histolojik olarak değerlendirildi.
Bulgular: Kontrol, düşük, orta ve yüksek doz grubu embriyoları morfolojik olarak değerlendirildiğinde, kraniokaudal uzunluk ortalamaları sırasıyla; 8493,73±1342,90 µm, 5743,61±770,3 µm, 5572,62±315,32 µm, 5306,55±1135,99 µm, somit sayıları ortalamaları sırasıyla; 15,91±1,62, 15,38±1,19, 15,13±0,83, 10,63±5,15‘dir. Dimenhidrinat dozundaki artışa bağlı olarak kraniokaudal uzunluklarının ve somit sayılarının azaldığı tespit edildi. Dimenhidrinat doz artışına bağlı olarak nöral tüp açıklığının arttığı belirlendi .
Sonuç: Bu çalışmada, erken dönem civciv embriyo modelinde dimenhidrinat uygulanan gruplarda doz artışına bağlı olarak nörogenezisin ve morfolojik gelişimin olumsuz etkilendiği görüldü.
Comparison of psychotropic drug preferences and side effects in old and young patients with schizophrenia and schizoaffective disorder
Authors: UÇAR Zehra , YILDIRIM Betül , TATLI Safiye Zeynep , ÖZEL KIZIL Erguvan Tuğba 
Published: December 2022

Purpose: The current study investigates the preferred psychotropic drug treatments and their tolerability in elderly patients (EP) with a diagnosis of schizophrenia or schizoaffective disorder compared to younger patients (YP).
Materials and Methods: The study included 154 EP and 195 YP with schizophrenia/schizoaffective disorder admitted to the outpatient unit at a university hospital in the last decade. The medical records of the patients were reviewed. The types and doses of antipsychotic drugs used by each patient, use of other psychotropic drugs, ongoing complaints, drug-related side effects and compliance with treatment were also examined.
Results: Second generation antipsychotic use was higher in YP (88% in YP, 80% in EP). Antipsychotic equivalent doses were found 266.63 mg in EP, 522.21 mg in YP, that also higher in the YP group. The use of clozapine (7% in EP, 37% in YP) and mood stabilizers (4.5% in EP, 18% in YP) were higher in YP. There was a higher rate of dose reduction of antipsychotic drugs in EP (21.5% in YP, 52% in EP). When the groups were compared in terms of the reasons of antipsychotic dose reduction, it was more frequent in EP due to side effects (21.4% in YP, 40% in EP), while the dose reduction due to remission was more common in YP (78.6% in YP, 60% in EP) .
Conclusion: Lower doses of antipsychotics in EP suggests milder symptoms or lower tolerability. The higher clozapine and mood stabilizer use in YP can be explained by avoiding side effects like extrapyramidal, cardiovascular and metabolic side effects that are more frequent in EP.
Serum oxidant, antioxidant, and paraoxonase levels in COVID-19 patients
Authors: DUYURAN Rumeysa , GÜRBÜZ Hüseyin , BAYRAKÇI Sinem , ÇİÇEK Hülya 
Published: December 2022

Purpose: The aim of his study was to determine serum oxidant status (TOS), antioxidant status (TAS), and paraoxonase (PON1) levels and to determine their diagnostic values in patients diagnosed with COVID-19.
Materials and Methods: The research was carried out on patients diagnosed with COVID-19. Within the scope of the study, a total of 87 patients with a diagnosis of COVID-19, 48 (55.1%) male and 39 (44.9%) were evaluated. Total antioxidant determination was performed using a microplate reader according to the Erel method. To calculate the Oxidative stress index (OSI), TOS and TAS levels were determined.
Results: Male gender was associated with high PON1, smoking with high TOS, the presence of hypertension and Diabetes mellitus (DM) diseases with low OSI, and the presence of asthma with low PON1. High PON1 was found to be associated with shorter hospitalization duration and high TOS was associated with longer hospitalization duration. TAS and TOS levels increased significantly due to the increase in CRP, TOS levels due to the increase in neutrophil level, OSI levels due to the increase in leukocyte level, PON1 levels increased due to the increase in LDH level TAS, TOS, OSI, and PON1 cut-off values were 1.41 (AUC: 0.647), 4.56 (AUC: 0.493), 0.421 (AUC: 0.505) and 340 (AUC: 0.536), sensitivity values were 65.5, 55.2, 48.3 and 51.7; specificity values were calculated respectively as 62.1, 46.6, 34.5 and 53.4.
Conclusion: Although it is seen that oxidative stress types have diagnostic value, there is a need for more comprehensive studies with larger samples on the subject.
Analysis of Clinical and Biochemical Characteristics of Patients With Genetically Confirmed Familial Hypercholesterolemia in Russian North Western District Residents
Authors: Korneva V. A. , Zacharova F. M. , Mandelstam M. Yu. , Bogoslovskaya T. Yu. , Orlov A. V. , Vasilyev V. B. , Kuznetsova T. Yu. 
Published: December 2022

Aim To compare results of clinical, laboratory, and genetic examination of patients with familial hypercholesterolemia (FHC).Material and methods 112 patients aged 40.2±17.9 years (49 men) were examined. The gene of low-density lipoprotein receptor (LDLR) was analyzed and evaluated using the Dutch Lipid Clinic Network (DLCN) criterion of lipid score ≥6. The LDLR gene mutation was searched for using the conformational polymorphism analysis followed by sequencing of the DNA of isolated LDLR gene exons.Results Mean variables of the blood lipid profile were total cholesterol (C), 10.12±2.32 mmol/l, LDL-C, 7.72±2.3 mmol/l. Corneal arcus was observed in 15 % of patients, tendon xanthomas in 31.8 %, and xanthelasma palpebrarum in 5.3 %. The types of LDLR gene mutations included missense mutations (42.8 %), mutations causing a premature termination of protein synthesis (41.1 %), and frameshift mutations (16.1 %). In the presence of a mutation in exon 4, patients with IHD compared to patients with no IHD had significantly higher levels of total C (10.88±2.08 mmol/l vs. 8.74±1.57 mmol/l, respectively, р=0.001) and LDL-C (8.60±2.14 mmol/l vs. 6.62±1.79 mmol/l, respectively, р=0.005). Patients with IHD compared to patients with no IHD and a mutation in LDLR gene exon 9 had only a higher LDL-C level (8.96±1.53 mmol/l vs. 6.92±1.59 mmol/l, respectively, р=0.022). A differentiated comparison of IHD patients using a logistic regression depending on the identified type of LDLR gene mutation produced formulas for calculating the odds ratio of IHD and myocardial infarction (MI) with adjustments for the patient’s age and baseline LDL.Conclusion The detection rate of the LDLR gene mutations was 42.8 % for missense mutations, 41.1 % for mutations causing a premature termination of protein synthesis, and 16.1 % for frameshift mutations. Blood lipid profiles did not differ between patients from different cities and with different types of LDLR gene mutations. Blood lipid profiles were different in IHD patients depending on the mutation type.
Flexible Work Agreements: Here to Stay but Uneven in Equity and Promoting Success
Authors: Kaplan Samantha 
Published: December 2022

A Review of:Hosoi, M., Reiter, L., & Zabel, D. (2021). Reshaping Perspectives on Flexible Work: The Impact of COVID-19 on Academic Library Management. portal: Libraries and the Academy 21(4), 695-713. doi:10.1353/pla.2021.0038
Objective – The article seeks to assess the current state and the future of flexible work agreements (FWAs) in research libraries.
Design – The authors held semi-structured interviews with 31 individuals in library leadership roles.
Setting – Large American or Canadian research libraries during the COVID-19 pandemic.
Subjects – 31 individuals in senior leadership roles (ex: associate dean, director) at the top 50 research libraries in North America (based on the Association of Research Libraries Investment Index).
Methods – Interviews were conducted and recorded over Zoom with participant, investigator, and note taker. Investigators developed a quantitative coding instrument based on a selection of the interviews, then coded all interviews independently. Coded data were evaluated for broader themes in a collaborative fashion.
Main Results – All participants had employees working partially or fully remotely at the time of the interviews. Half of participants observed gains in productivity during the pandemic, although even more commented on technology challenges. Other positives included remote project success and more inclusive meetings; other negatives included caregiving and job duties that did not allow for remote work.
Conclusion – While FWAs were widely available pre-pandemic, they were not normative. The majority of participants think flexible work will only increase in libraries and will influence recruitment and retention of employees, as well as utilization of library space.
A new predictor for prediabetes: Chemerin
Authors: ERGÜN Emine , OR KOCA Arzu , BEYAN Esin , ERTUĞRUL Derun Taner , AKKAN Tolga , DAL Kürşat 
Published: December 2022

Objective: It was aimed to investigate irisin and chemerin levels in prediabetic individuals and their value in predicting prediabetes.
Method: Thirty-eight prediabetic patients aged 18-65 years (22 impaired fasting glucose (IFG), 10 impaired glucose tolerance (IGT), 6 patients with coexisting IFG and IGT) and thirty-five healthy volunteers were included in which was designed as a cross-sectional study. The basic demographic characteristics of all participants in the case and control groups were compared with the serum chemerin, irisin, creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), high-density lipoprotein (HDL-cholesterol), low-density lipoprotein (LDL-cholesterol), triglyceride (TG), free thyroxine (sT4), and thyroid-stimulating hormone (TSH) levels.
Result: Serum chemerin level was found to be higher in the prediabetic group (p=0.03), while no significant difference was found for the irisin level between the two groups. In the multivariate logistic regression analysis, we showed that chemerin was an independent risk factor in predicting prediabetes. There was a positive correlation (p=0.01, r=0.279) between all participants' body mass index (BMI) and chemerin level and a negative correlation between irisin level and high-density lipoprotein cholesterol (HDL-C) level, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (p=0.04 r=-0.295, p=0.01 r=-0.407, respectively).
Conclusion: Chemerin is a new generation chemokine that predicts prediabetes. Studies aimed at irisin and chemerin may provide important role to prevent the prediabetes to Type 2 diabetes progression.
Fiqh Learning Using Media and Its Implication towards Students Understanding: A Case Study at MAN 2 Mataram
Authors: Syukri Syukri 
Published: December 2022

The fiqh (Islamic law) learning process using media among Islamic studies teachers at MAN 2 Mataram has huge implications for the quality of the learning process. Fiqh learning, especially on the topics of hajj and umrah as well as the treatment of the deceased, with media support, turns out to be exciting, and it accelerates and enhances students' understanding. Teachers of Islamic studies can explain hajj and umrah as well as bathing and praying the deceased through a demonstration using a miniature of Ka’bah and a doll representing a corpse, respectively. Students practice the lessons individually and in groups upon the teacher's demonstration. The process of Fiqh learning using media has an implication towards the increase of students understanding and their ability to memorize the lessons.
Keywords: Fiqh learning, media, method, demonstration, practice
Abstrak: Proses pembelajaran Fikh menggunakan alat peraga di kalangan guru agama Islam Madrasah Aliyah Negeri (MAN) 2 Mataram memberikan implikasi yang besar terhadap peningkatan pemahaman siswa cukup tinggi dan memiliki kemampuan daya ingat yang lama. Pembelajaran mata pelajaran Fikh menggunakan alat peraga khusus pada materi haji dan umrah menggunakan kabah dan cara memandikan mayat dan menshalatkannyn menggunakan boneka sangat menyenangkan, mempercepat, dan memperjelas pemahaman siswa. Metode diterapkan guru agama Islam adalah metode demonstratif dengan alat peraga miniatur kabah dan boneka mayat. Usai guru mendemonstrasikan alat peraga sesuai materi, siswa langsung mempraktekkan secara individu dan kelompok. Pembelajaran Fikh menggunakan alat peraga menghasilkan peningkatkan pemahaman siswa yang cukup signifikans dan memiliki kemampuan daya ingat yang sangat lama.
Tercüme Eserlerde Dipnot Verilirken Verilen Dipnot İle Adres Gösterilen Temel Kaynağın Uyuşması Meselesi (Hayri Kırbaşoğlu Hadis Müdafaası Örneği)
Authors: PALABIYIK Abdülkadir 
Published: December 2022

Dipnotlar verilerek yapılan akademik ve bilimsel çalışmalarda verilen bilgilerle dipnot olarak gösterilen adresteki bilgilerin tutarlılığı aynı zamanda yapılan ilmi çalışmaya güveni de artırır. Özellikle aynen alıntılarda bu tutarlılık daha da önem arz eder. Bunun yanında karşılaştırma, telmih, tahkiye etme, özet olarak sunma vb. dipnot şekilleri de olabilir. Bu durumlarda ise alıntı ile dipnot arasındaki ilişki ve irtibatın nasıl olduğunu belirten bakınız (bkz), karşılaştırınız (krş.), benzer rivayetler için bakınız gibi kısaltmalar veya açıklayıcı cümleler verilmelidir. Eğer böyle bir durum yoksa dipnotlar genellikle aynen alıntı gibi anlaşılır.
İbn Kuteybe’nin “Te’vilü Muhtelifi’l-Hadis” adlı kitabını ve Hayri Kırbaşoğlu tarafından yapılan “Hadis Müdafaası” isimli tercümesini dipnot-referans kaynak ilişkisi ve tutarlılığı açısından inceledik. Te’vil’in Arapçasında ayetlerin yerleri gösterilmiş fakat “hadislerin tahrici” yapılmamıştır. Buna karşılık Kırbaşoğlu tercümede “hadislerin tahrici”ni de vermiştir. Biz de bu tahriçlerden hareketle tercümenin Te’vil’deki Arapçası ve dipnotlarda verilen temel hadis kaynaklarından sadece veya birinci kaynak olarak verilen Buhari’nin Sahih’indeki yerlerini bulup karşılaştırmaya çalıştık.
Yaptığımız karşılaştırma sonucu özellikle dipnotlarda kaynak olarak gösterilen yerde olmayan hadisler, eksik olanlar, konu farklılığı olanlar ve Te’vilin ana metni ve tercümesinde bahsedilen konu ile alakası olmayan hadislerin var olması özellikle dikkat çekmektedir..
The Influence of Intellectual Capital on Firm Value with Financial Performance as an Intervening Variable in High-Ic . Companies
Authors: Amalia Anggun , Hermawan Sigit 
Published: December 2022

This study aims to determine the effect of intellectual capital on firm value with financial performance as an intervening variable. The variables used in this study are Intellectual Capital (X1) as measured by VAIC, Firm Value (Y) as measured by Tobins Q and Financial Performance (Z) as measured by ROE. This research includes associative quantitative research. The data in this study is secondary data. The population in this study are Healthcare Industry companiesxlisted on thexStock Exchange inx2014-2019. The samplingxtechnique used was purposivexsampling. The analytical technique usedxin this studyxuses the Partial LeastxSquare (PLS) technique. The resultsxin this study show that IC has an effect on the Financial Performance of Healthcare Industry companies. IC affects the value of pharmaceutical companies in the Healthcare Industry. Financial Performance has no effect on the Healthcare Industry Company Value. Financial Performance can not mediate the relationship between IC and Healthcare Industry Company Value.
Lifestyle Modification and medication use among Diabetes Mellitus Patients Attending Jimma University Medical Center, Jimma Zone, South West Ethiopia
Authors: Garedow Aster Wakjira , Jemaneh Tsiyon Mekoya , Hailemariam Addisalem Gebresilase , Tesfaye Gorfineh Teshome 
Published: December 2022

Abstract
Background: Diabetes, a non-communicable metabolic disease, causes multiple complications and deaths worldwide. It is a complex, chronic disease that requires continuous medical care with multifactorial risk reduction strategies beyond glycemic control. Ongoing patient education and
Self-management support are critical for preventing acute complications and reducing the risk of long-term complications. There is ample evidence that healthy lifestyle choices, such as a healthy diet, moderate weight loss, and regular exercise, can maintain normal blood sugar levels and minimize diabetes-related complications. In addition, this lifestyle change has a major impact on controlling hyperglycemia and can help to maintain normal blood sugar levels.
Objective: This study aimed to assess lifestyle modification and medication use in patients with diabetes mellitus at Jimma University medical center.
Methodology: Hospital-based prospective cross-sectional study was conducted to assess medication use and lifestyle modifications at Jimma University medical center. Data were checked for completeness, then entered into Epidata version 4.2 software and exported to SPSS version 21.0. Pearson’s chi-square test was performed to determine the association between KAP and independent factors. Variables with a p value <0.05 were considered significant.
Result: A total of 190 participants took part in this study with a response rate of 100%. In this study, 69(36.3%) participants had good knowledge, 82(43.2%) moderate knowledge and 39(20.5%) poor knowledge, 153(85.8%) had positive attitudes, 141 (74.2%) had good practice. Marital status, Occupational status and educational status were significantly associated with knowledge and attitude towards LSM and medication use. Marital status was the only variable that remained significantly associated with knowledge, attitude and practice towards LSM and medication use. Occupation, education, and marital status were significantly associated with knowledge and attitude towards LSM and medication use
Conclusion: The result of this study showed that more than 20% of the participants had poor knowledge, attitude, and practice towards medication use and LSM.Marital status was the only variable which remained to be significantly associated with KAP towards LSM and medication use
Improvised Dynamic Round-Robin Scheduling for Optimum Resource Utilization in Cloud Systems
Authors: Aradhya Suvarna N , Priya Rashmi 
Published: December 2022

Abstract
Task Scheduling is the process of assigning the incoming tasks to the available systems for optimum utilization of resources (CPU, Memory, Bandwidth, etc.). Optimum, in the present context implies executing maximum number of tasks using minimum of resources. In large scale Cloud Computing, resource optimization plays a critical role as it determines the quality of service (QoS) offered to customers. Therefore, task scheduling algorithm for parallel processing directly relates to QoS and is fundamental to understanding Resource Utilization, Inter-Process Communication, Network Latency, Load Balancing, Job Migration and Fault Tolerance. In this paper, an effort is made to explore and understand some of the basic scheduling algorithms through an experimental study. Algorithms are implemented in a cloud scenario. The results are construed with respect to several performance indicators that affect the QoS.
Use PROMs adapted for children and avoid PROMs developed for adults. Translation and Validation of paediatric IKDC subjective knee form in Lithuanian Children and Adolescents with Knee Disorders
Authors: Martinkeniene Viktorija Brogaite , Šaikus Andrius , Austys Donatas , Brazaitis Andrius , Bernotavičius Giedrius 
Published: December 2022

Abstract
Background/Purpose: The usage of children adapted PROMs is encouraged. This study is designed to translate and adapt the Pedi-IKDC for Lithuanian children with knee disorders and evaluate the psychometric properties of the new Pedi-IKDC version.
Methods: The translation process was performed under international guidelines. Patients aged 11-17 years with various knee disorders participated at three surveys and completed the Pedi-IKDC, Lysholm and PedsQL questionnaires. The internal consistency and reproducibility were determined by Cronbach alpha (a) statistics and intraclass correlation coefficient (ICC) respectively. For evaluation of reliability the standard error of measurement (SEM) and the smallest detectable change (SDC) were estimated. Regarding criterion validity, the Pearson correlations were assessed between Pedi-IKDC and Lysholm, PedsQL scores. The responsiveness to change was checked by calculating the effect size (ES) and standardized response mean (SRM). The floor and ceiling effects were verified for content validity.
Results: The Cronbach alpha (a) was 0.91 for overall score, 0.75 for symptoms and 0.92 for sport/function component of the score. The ICC for overall scores was 0.98 and from 0.87 to 0.98 for separate questions. SEM was 2.97 and SDC – 8.23. Moderate correlations (0.8> r > 0.5) were found to Lysholm and PedsQL physical functioning domain score, weak (0.5>r > 0.2) - to overall PedsQL score. Floor and ceiling effects were - 3,3%, and 1,6% respectively. The ES was 1,98 and SRM- 1,72.
Conclusions: The Lithuanian Pedi-IKDC version is suitable measurement tool to assess outcomes within paediatric population with different knee disorders. All the psychometric properties demonstrated acceptable results.
An Analytical Study of the Flow and Heat Transfer of Viscoelastic Fluid Between Two Wavy Walls Situated Symmetrically About a Mid Plane
Authors: Sahoo A. C. 
Published: December 2022

Abstract
In this work the two dimensional flow and heat transfer of a Visco-elastic fluid flowing steadily between two walls having periodic deformation and situated symmetrically about a mid plane is studied. The equation of motion and energy are solved with the help of the perturbation method taking the deformation of the boundaries small. Energy equation is solved under two types of thermal boundary conditions; (i) both walls are maintained at the same constant temperature and (ii) one wall is at constant temperature while the other wall is thermally insulated. The effects of visco-elastic parameter ‘K’ on the velocity distribution has been studied by draining the streamlines. We also note that the temperature distribution is not affected the presence of viscoelasticity of the liquid.