bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revised workflow practices in the management of acute invasive fungal sinusitis during the coronavirus disease 2019 pandemic
Authors: Kurien R , Varghese L , Cherian L M , Sundaresan R , John M , Mammen M D , Inja R R , Manesh A , Paul H , Gurijala P R , Michael J S , Thomas M , Abhilash K P P , Varghese A M , Rupa V 
Published: August 2022

AbstractObjectiveTo document changes in evaluation protocols for acute invasive fungal sinusitis during the coronavirus disease 2019 pandemic, and to analyse concordance between clinical and histopathological diagnoses based on new practice guidelines.MethodsProtocols for the evaluation of patients with suspected acute invasive fungal sinusitis both prior and during the coronavirus disease 2019 period are described. A retrospective analysis of patients presenting with suspected acute invasive fungal sinusitis from 1 May to 30 June 2021 was conducted, with assessment of the concordance between clinical and final diagnoses.ResultsAmong 171 patients with high clinical suspicion, 160 (93.6 per cent) had a final histopathological diagnosis of invasive fungal sinusitis, concordant with the clinical diagnosis, with sensitivity of 100 per cent, positive predictive value of 93.6 per cent and negative predictive value of 100 per cent.ConclusionThe study highlights a valuable screening tool with good accuracy, involving emphasis on ‘red flag’ signs in high-risk populations. This could be valuable in situations demanding the avoidance of aerosol-generating procedures and in resource-limited settings facilitating early referral to higher level care centres.
Northern Tosk Albanian
Authors: Coretta Stefano , Riverin-Coutlée Josiane , Kapia Enkeleida , Nichols Stephen 
Published: August 2022

Albanian (endonym: Shqip; Glotto: alba1268) is an Indo-European language which has been suggested to form an independent branch of the Indo-European family since the middle of the nineteenth century (Bopp 1855, Pedersen 1897, Çabej 1976). Though the origin of the language has been debated, the prevailing opinion in the literature is that it is a descendant of Illyrian (Hetzer 1995). Albanian is currently spoken by around 6–7 million people (Rusakov 2017: 552; Curtis 2018: 1800), the majority of whom live in Albania and Kosovo, with others in Italy, Greece, North Macedonia and Montenegro. Figure 1 shows a map of the main Albanian-speaking areas of Europe, with major linguistic subdivisions according to Gjinari (1988) and Elsie & Gross (2009) marked by different colours and shades.
What Controls the Large‐Scale Efficiency of Carbon Transfer Through the Ocean's Mesopelagic Zone? Insights From a New, Mechanistic Model (MSPACMAM)
Authors: Dinauer Ashley , Laufkötter Charlotte , Doney Scott C. , Joos Fortunat 
Published: August 2022

AbstractA key challenge for current‐generation Earth system models (ESMs) is the simulation of the penetration of sinking particulate organic carbon (POC) into the ocean interior, which has implications for projections of future oceanic carbon sequestration in a warming climate. This paper presents a new, cost‐efficient, mechanistic 1D model that prognostically calculates POC fluxes by carrying four component particles in two different size classes. Gravitational settling and removal/transformation processes are represented explicitly through parameterizations that incorporate the effects of particle size and density, dissolved oxygen, calcite and aragonite saturation states, and seawater temperature, density, and viscosity. The model reproduces the observed POC flux attenuation at 22 locations in the North Atlantic and North Pacific. The model is applied over a global ocean domain with seawater properties prescribed from observation‐based climatologies in order to address an important scientific question: What controls the spatial pattern of mesopelagic POC transfer efficiency? The simulated vertical POC transfer is more efficient at high latitudes than at low latitudes with the exception of oxygen minimum zones, which is consistent with recent inverse modeling and neutrally buoyant sediment trap studies. Here, model experiments show that the relative abundance of large‐sized, rapidly sinking particles and the slower rate of remineralization at high latitudes compensate for the region's lack of calcium carbonate ballast and the cold‐water viscous resistance, leading to higher transfer efficiencies compared to low‐latitude regions. The model could be deployed in ESMs in order to diagnose the impacts of climate change on oceanic carbon sequestration and vice versa.
Dynamics of the Atlantic Marine Intertropical Convergence Zone
Authors: Giordani Hervé , Peyrillé Philippe 
Published: August 2022

AbstractA generalized ω‐equation is used to identify the contributions from different processes that force upward motions in the Atlantic Marine ITCZ (AMI) from a numerical mesoscale simulation of June 2010. This ω‐equation separates the diabatic heating contributions, which lie at the core of the Weak Temperature Gradient (WTG) framework, from the dynamical terms. Three layers of atmosphere are found with different balance. In the Marine Atmospheric Boundary‐Layer (MABL), the upward motions in the AMI are induced by the frontogenesis and buoyancy components, which are regulated by the ageostrophic adjustment due to the presence of thermal‐wind imbalance. The balance of these three processes well captures the variability of the vertical velocity and the associated precipitation, meaning that boundary‐layer processes play a central role in the AMI dynamics. In the layer [600–2,000 m], a zone of strong vertical wind‐shear just above the MABL, the upward motions are induced by the ageostrophic adjustment and radiative components, which are counteracted by evaporation of convective precipitation. Above 2,000 m the ascending motions are driven by the deep convection heating, as expected by the WTG framework, and more surprisingly by the ageostrophic adjustment term within the Tropical Easterly Jet. Thanks to the use of the ω‐equation, these results extend the current WTG framework to the boundary layer, where it is not expected to hold. In the free troposphere, the WTG framework only accounts for half of the AMI ascent, the other half being forced by the dynamical terms.
Size and Composition of the MORB+OIB Mantle Reservoir
Authors: Hofmann A. W. , Class C. , Goldstein S. L. 
Published: August 2022

AbstractMost efforts to characterize the size and composition of the mantle that complements the continental crust have assumed that the mid‐ocean ridge basalt (MORB) source is the incompatible‐element depleted residue of continental crust extraction. The use of Nd isotopes to model this process led to the conclusion that the “depleted MORB reservoir” is confined to the upper ∼30% of the mantle, leaving the lower mantle in a more “primitive” state. Here, we use Nb/U and Ta/U to evaluate mass and composition of the mantle reservoir residual to continent extraction and find that it exceeds 60% of the total mantle. Thus, the (Nb, Ta)/U‐based mass balance conflicts with the ε(Nd)‐based mass balance, and this invalidates the classical 3‐reservoir silicate Earth model (continental crust, depleted mantle, and primitive mantle). Including the combined MORB + ocean island basalt (OIB) sources in the ε(Nd)‐based mass balance does not reconcile the conflict as it would require their average ε(Nd) to be ≤3.0, much lower than observed MORB + OIB ε(Nd) averages. We resolve this conflict by invoking an additional, “early enriched reservoir” (EER), formed prior to extraction of significant continental crust, but now hidden or lost. This EER differs from EERs previously invoked by having no Nb‐Ta anomaly. We suggest that it originated as an early mafic crust, which had unfractionated (Nb, Ta)/U but fractionated Sm/Nd ratios. The corresponding “early depleted” reservoir generated the present‐day continental crust and the “residual mantle” MORB‐OIB reservoir, which occupies at least 63% of the present‐day mantle and is only moderately depleted in incompatible trace elements.
Ocean‐Forced Instability of the West Antarctic Ice Sheet Since the Mid‐Pleistocene
Authors: Wang Jiakai , Tang Zheng , Wilson David J. , Chang Fengming , Xiong Zhifang , Li Dongyong , Li Tiegang 
Published: August 2022

AbstractEvidence on West Antarctic Ice Sheet (WAIS) instability through Pleistocene glacial/interglacial cycles can provide fundamental constraints on interactions between the climate system and cryosphere. To explore such ice sheet‐ocean‐climate processes on orbital timescales over the last ∼770 ka, we provide continuous records of iceberg‐rafted debris (IRD) content and clay mineralogy, supported by detrital Sr‐Nd isotopes from the pronounced IRD peaks, in gravity core ANT34/A2‐10 from the Amundsen abyssal plain. The IRD record reveals interglacial WAIS instability since ∼770 ka, while comparison to the clay mineralogy record and published records of regional oceanic and atmospheric forcing suggests a temporal link with a strengthened Antarctic Circumpolar Current, enhanced deepwater ventilation, and poleward‐shifted southern westerly winds. In addition, the Sr‐Nd isotope signature of the detrital sediments indicates a shift in provenance around Marine Isotope Stage (MIS) 16, potentially linked to regional oceanic circulation changes. We suggest that an expanded Ross Gyre was important for controlling iceberg trajectories and sediment transport to the site before MIS 16, whereas modern‐like iceberg trajectories were established after MIS 16, probably related to a poleward shift of the Amundsen Sea Low after the end of the Mid‐Pleistocene Transition. This reorganization of the ocean and atmospheric circulation was followed by an interval of enhanced WAIS variability during MIS 15 to 13, which was linked to strong orbital and ocean forcing. These insights into the role of ocean‐atmosphere forcing on the past behavior of the WAIS may improve our framework for understanding future changes in this region.
Early anti-VEGF treatment for radiation maculopathy and optic neuropathy: lessons learned
Authors: Powell Brittany E. , Chin Kimberly J. , Finger Paul T. 
Published: August 2022

AbstractRadiation therapy has saved both sight and life for eye cancer patients. The most common methods include ophthalmic plaque brachytherapy and external beam techniques. However, subsequent dose-dependent radiation vasculopathy invariably occurs within and around the targeted zone. In 2006, Finger discovered that periodic intravitreal anti-vascular endothelial growth factor (anti-VEGF) bevacizumab could reverse and suppress intraocular radiation vasculopathy. At first, it was administered at the onset of radiation-related vision loss. Though bevacizumab induced regression of macular oedema, retinal haemorrhages and cotton-wool infarcts, most patients were left with residual retinal damage, manifest as metamorphopsia and loss of vision. These results led to earlier and earlier anti-VEGF interventions: first after signs of progressive radiation retinopathy, and then for signs of radiation maculopathy, and finally for high-risk eyes with no clinical signs of retinopathy. Earlier initiation of intravitreal anti-VEGF therapy typically resulted in greater restoration and preservation of macular anatomy, reductions of retinal haemorrhages, resolution of cotton-wool spots and vision preservation. Recent research on optical coherence tomography angiography (OCT-A) has revealed that radiation vasculopathy occurs prior to clinical ophthalmic signs or symptoms. Therefore, it seemed reasonable to consider treating high-risk patients (considered certain to eventually develop radiation maculopathy) to prevent or delay vision loss. Herein, we describe the evolution of treatment for radiation maculopathy as well as recent research supporting anti-VEGF treatment of high-risk patients immediately following radiation to maximize vision outcomes.
Understanding the lithium–sulfur battery redox reactions via operando confocal Raman microscopy
Authors: Lang Shuangyan , Yu Seung-Ho , Feng Xinran , Krumov Mihail R. , Abruña Héctor D. 
Published: August 2022

AbstractThe complex interplay and only partial understanding of the multi-step phase transitions and reaction kinetics of redox processes in lithium–sulfur batteries are the main stumbling blocks that hinder the advancement and broad deployment of this electrochemical energy storage system. To better understand these aspects, here we report operando confocal Raman microscopy measurements to investigate the reaction kinetics of Li–S redox processes and provide mechanistic insights into polysulfide generation/evolution and sulfur deposition. Operando visualization and quantification of the reactants and intermediates enabled the characterization of potential-dependent rates during Li–S redox and the linking of the electronic conductivity of the sulfur-based electrode and concentrations of polysulfides to the cell performance. We also report the visualization of the interfacial evolution and diffusion processes of different polysulfides that demonstrate stepwise discharge and parallel recharge mechanisms during cell operation. These results provide fundamental insights into the mechanisms and kinetics of Li–S redox reactions.
Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma
Authors: Coy Shannon , Wang Shu , Stopka Sylwia A. , Lin Jia-Ren , Yapp Clarence , Ritch Cecily C. , Salhi Lisa , Baker Gregory J. , Rashid Rumana , Baquer Gerard , Regan Michael , Khadka Prasidda , Cole Kristina A. , Hwang Jaeho , Wen Patrick Y. , Bandopadhayay Pratiti , Santi Mariarita , De Raedt Thomas , Ligon Keith L. , Agar Nathalie Y. R. , Sorger Peter K. , Touat Mehdi , Santagata Sandro 
Published: August 2022

AbstractHow the glioma immune microenvironment fosters tumorigenesis remains incompletely defined. Here, we use single-cell RNA-sequencing and multiplexed tissue-imaging to characterize the composition, spatial organization, and clinical significance of extracellular purinergic signaling in glioma. We show that microglia are the predominant source of CD39, while tumor cells principally express CD73. In glioblastoma, CD73 is associated with EGFR amplification, astrocyte-like differentiation, and increased adenosine, and is linked to hypoxia. Glioblastomas enriched for CD73 exhibit inflammatory microenvironments, suggesting that purinergic signaling regulates immune adaptation. Spatially-resolved single-cell analyses demonstrate a strong spatial correlation between tumor-CD73 and microglial-CD39, with proximity associated with poor outcomes. Similar spatial organization is present in pediatric high-grade gliomas including H3K27M-mutant diffuse midline glioma. These data reveal that purinergic signaling in gliomas is shaped by genotype, lineage, and functional state, and that core enzymes expressed by tumor and myeloid cells are organized to promote adenosine-rich microenvironments potentially amenable to therapeutic targeting.
Catalytic oxidation of polystyrene to aromatic oxygenates over a graphitic carbon nitride catalyst
Authors: Cao Ruochen , Zhang Mei-Qi , Hu Chaoquan , Xiao Dequan , Wang Meng , Ma Ding 
Published: August 2022

AbstractThe continuous increase in manufacturing coupled with the difficulty of recycling of plastic products has generated huge amounts of waste plastics. Most of the existing chemical recycling and upcycling methods suffer from harsh conditions and poor product selectivity. Here we demonstrate a photocatalytic method to oxidize polystyrene to aromatic oxygenates under visible light irradiation using heterogeneous graphitic carbon nitride catalysts. Benzoic acid, acetophenone, and benzaldehyde are the dominant products in the liquid phase when the conversion of polystyrene reaches >90% at 150 °C. For the transformation of 0.5 g polystyrene plastic waste, 0.36 g of the aromatic oxygenates is obtained. The reaction mechanism is also investigated with various characterization methods and procedes via polystyrene activation to form hydroxyl and carbonyl groups over its backbone via C–H bond oxidation which is followed by oxidative bond breakage via C–C activation and further oxidation processes to aromatic oxygenates.
The combination of genomic offset and niche modelling provides insights into climate change-driven vulnerability
Authors: Chen Yilin , Jiang Zhiyong , Fan Ping , Ericson Per G. P. , Song Gang , Luo Xu , Lei Fumin , Qu Yanhua 
Published: August 2022

AbstractGlobal warming is increasingly exacerbating biodiversity loss. Populations locally adapted to spatially heterogeneous environments may respond differentially to climate change, but this intraspecific variation has only recently been considered when modelling vulnerability under climate change. Here, we incorporate intraspecific variation in genomic offset and ecological niche modelling to estimate climate change-driven vulnerability in two bird species in the Sino-Himalayan Mountains. We found that the cold-tolerant populations show higher genomic offset but risk less challenge for niche suitability decline under future climate than the warm-tolerant populations. Based on a genome-niche index estimated by combining genomic offset and niche suitability change, we identified the populations with the least genome-niche interruption as potential donors for evolutionary rescue, i.e., the populations tolerant to climate change. We evaluated potential rescue routes via a landscape genetic analysis. Overall, we demonstrate that the integration of genomic offset, niche suitability modelling, and landscape connectivity can improve climate change-driven vulnerability assessments and facilitate effective conservation management.
Three-dimensional nanoframes with dual rims as nanoprobes for biosensing
Authors: Hilal Hajir , Zhao Qiang , Kim Jeongwon , Lee Sungwoo , Haddadnezhad MohammadNavid , Yoo Sungjae , Lee Soohyun , Park Woongkyu , Park Woocheol , Lee Jaewon , Lee Joong Wook , Jung Insub , Park Sungho 
Published: August 2022

AbstractThree-dimensional (3D) nanoframe structures are very appealing because their inner voids and ridges interact efficiently with light and analytes, allowing for effective optical-based sensing. However, the realization of complex nanoframe architecture with high yield is challenging because the systematic design of such a complicated nanostructure lacks an appropriate synthesis protocol. Here, we show the synthesis method for complex 3D nanoframes wherein two-dimensional (2D) dual-rim nanostructures are engraved on each facet of octahedral nanoframes. The synthetic scheme proceeds through multiple executable on-demand steps. With Au octahedral nanoparticles as a sacrificial template, sequential processes of edge-selective Pt deposition and inner Au etching lead to Pt octahedral mono-rim nanoframes. Then, adlayers of Au are grown on Pt skeletons via the Frank-van der Merwe mode, forming sharp and well-developed edges. Next, Pt selective deposition on both the inner and outer boundaries leads to tunable geometric patterning on Au. Finally, after the selective etching of Au, Pt octahedral dual-rim nanoframes with highly homogeneous size and shape are achieved. In order to endow plasmonic features, Au is coated around Pt frames while retaining their geometric shape. The resultant plasmonic dual-rim engraved nanoframes possess strong light entrapping capability verified by single-particle surface-enhanced Raman scattering (SERS) and show the potential of nanoprobes for biosensing through SERS-based immunoassay.
Sex differences in machine learning computed tomography-derived fractional flow reserve
Authors: Al Rifai Mahmoud , Ahmed Ahmed Ibrahim , Han Yushui , Saad Jean Michel , Alnabelsi Talal , Nabi Faisal , Chang Su Min , Cocker Myra , Schwemmer Chris , Ramirez-Giraldo Juan C. , Zoghbi William A. , Mahmarian John J. , Al-Mallah Mouaz H. 
Published: August 2022

AbstractCoronary computed tomography angiography (CCTA) derived machine learning fractional flow reserve (ML-FFRCT) can assess the hemodynamic significance of coronary artery stenoses. We aimed to assess sex differences in the association of ML-FFRCT and incident cardiovascular outcomes. We studied a retrospective cohort of consecutive patients who underwent clinically indicated CCTA and single photon emission computed tomography (SPECT). Obstructive stenosis was defined as ≥ 70% stenosis severity in non-left main vessels or ≥ 50% in the left main coronary. ML-FFRCT was computed using a machine learning algorithm with significant stenosis defined as ML-FFRCT < 0.8. The primary outcome was a composite of death or non-fatal myocardial infarction (D/MI). Our study population consisted of 471 patients with mean (SD) age 65 (13) years, 53% men, and multiple comorbidities (78% hypertension, 66% diabetes, 81% dyslipidemia). Compared to men, women were less likely to have obstructive stenosis by CCTA (9% vs. 18%; p = 0.006), less multivessel CAD (4% vs. 6%; p = 0.25), lower prevalence of ML-FFRCT < 0.8 (39% vs. 44%; p = 0.23) and higher median (IQR) ML-FFRCT (0.76 (0.53–0.86) vs. 0.71 (0.47–0.84); p = 0.047). In multivariable adjusted models, there was no significant association between ML-FFRCT < 0.8 and D/MI [Hazard Ratio 0.82, 95% confidence interval (0.30, 2.20); p = 0.25 for interaction with sex.]. In a high-risk cohort of symptomatic patients who underwent CCTA and SPECT testing, ML-FFRCT was higher in women than men. There was no significant association between ML-FFRCT and incident mortality or MI and no evidence that the prognostic value of ML-FFRCT differs by sex.
The association of knowledge, attitudes and behaviors related to salt with 24-h urinary sodium, potassium excretion and hypertensive status
Authors: Du Xiaofu , Fang Le , Xu Jianwei , Chen Xiangyu , Bai Yamin , Wu Jing , Wu Lin , Zhong Jieming 
Published: August 2022

AbstractTo understand the association between sodium and potassium consumption levels, hypertension and knowledge, attitudes and behaviors (KAB) toward salt and the commitment to effective sodium reduction and potassium supplementation to achieve the purpose of suppressing hypertension. A stratified multistage random sampling method was used to obtain a representative provincial sample of 7512 residents aged 18–69 years through a cross-sectional survey by the Salt Reduction and Hypertension Prevention Project (SRHPP) in Zhejiang Province of China in 2017–2018. A screening including demographic, anthropometric, salt-related KAB and physical measurements was implemented, and 24-h urine of approximately 1/5 of the participants was collected and tested. The mean age was 44.8 years, 50.1% were women, 44.0% lived in urban areas, and hypertension or prehypertension accounted for approximately 35.0%. The mean 24-h urinary sodium and potassium excretion were 3848.5 (1661.1) mg/d and 1491.1 (710.9) mg/d, respectively. KAB in urban areas was generally more favorable than in rural areas, women were better than men, and the optimal blood pressure group was better than the other two groups (P < 0.05). However, the awareness and correct use rate of salt-restricted spoons, low-sodium salt and nutrition labeling were lower. A multivariable linear regression model indicated that KAB had a smaller effect on sodium (two indicators effective for promoting sodium reduction) and a greater effect on potassium (six indicators effective for promoting potassium supplementation) and mainly focused on knowledge and behavior indicators. A multivariable logistic regression model indicated that mastering more knowledge and taking active measures could effectively reduce the transition to hypertension, even if the individual was already in prehypertension. There is much room for improvement of salt-related KAB in the Chinese population. A clear association indicates that KAB can help to reduce sodium and supplement potassium, especially potassium, and help to suppress the development of hypertension. The role of beliefs in KAB should be fully valued and improved, similar to knowledge and behaviors. This study provides important evidence and insight into China’s efforts to meet the targets of salt reduction and hypertension prevention.