bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics and factors associated to patients discharging from hospital without an implantable cardioverter defibrillator after out-of-hospital cardiac arrest
Authors: Sharifzadehgan Ardalan , Gaye Bamba , Rischard Julien , Bougouin Wulfran , Karam Nicole , Waldmann Victor , Narayanan Kumar , Dumas Florence , Gandjbakhch Estelle , Algalarrondo Vincent , Beganton Frankie , Extramiana Fabrice , Lellouche Nicolas , Lamhaut Lionel , Jost Daniel , Cariou Alain , Jouven Xavier , Marijon Eloi 
Published: June 2022

Abstract

Aims
Guidelines recommend that in the absence of reversible cause for sudden cardiac arrest (SCA), implantable cardioverter defibrillator (ICD) should be performed to prevent further fatal event. We sought to describe the frequency and characteristics of patients discharged from the hospital without ICD after the SCA in the daily practice.

Methods and results
From 2011 to 2018, all SCAs related to a cardiac cause admitted alive across the 48 hospitals of Great Paris Area were prospectively enrolled. Two investigators thoroughly reviewed each medical report to ensure accuracy of the assigned diagnosis towards identifying the cause of SCA and ICD implantation. Out of the 4314 SCA admitted alive at hospital admission, 1064 cardiac-related SCA survivors were discharged alive from hospital, including 356 patients (33.5%) with an ICD and 708 (66.5%) without. The principal underlying cause of SCA among those discharged without an ICD was acute coronary syndrome (ACS; 602, 85%), chronic coronary artery disease (41, 5.8%), structural non-ischaemic heart disease (48, 6.8%), and non-structural heart disease (17, 2.4%). Among ACS-related SCA, 93.8% (602/642) discharged without an ICD. The unique factor associated with non-ICD implantation in the setting of ACS was immediate coronary angioplasty (odds ratio 4.22, 95% confidence interval 1.86–9.30, P &lt; 0.001).

Conclusion
Two-thirds of SCA survivors were discharged without an ICD, mainly in the setting of ACS. The unique factor associated with non-ICD implantation among ACS was immediate coronary angioplasty emphasizing the fact that ACS definition must be precise since associated with ICD implantation or not.
Association between Early Oral β-Blocker Therapy and Risk for In-Hospital Major Bleeding after Percutaneous Coronary Intervention for Acute Coronary Syndrome: Findings from CCC-ACS Project
Authors: Xu Shaopeng , Li Ziping , Yang Tianqi , Li Linjie , Song Xiwen , Hao Yongchen , Smith Sidney C , Fonarow Gregg C , Morgan Louise , Liu Jing , Liu Jun , Zhao Dong , Yang Qing , Zhou Xin , Li Yongle 
Published: June 2022

Abstract

Aims
Information regarding β-blocker use and bleeding risk in patients on antithrombotic therapy in contemporary practice is limited. We examined the association between early (within the first 24 hours) oral β-blocker therapy and major in-hospital bleeds among acute coronary syndrome (ACS) patients treated with percutaneous coronary intervention (PCI).

Methods and Results
In the Improving Care for Cardiovascular Disease in China-ACS project, among patients without contraindications to β-blocker, we examined the association between early oral β-blocker exposure [users/non-users, dosing, and type (metoprolol vs. bisoprolol)] and major in-hospital bleeds. Of the 43,640 eligible patients, 36.0% patients received early oral β-blocker and 637 major bleeds were recorded. Compared with non-users, early oral β-blocker was associated reduced risks for major bleeds [odds ratio (OR): 0.48; 95% confidence interval (CI): 0.38-0.61] and in-hospital mortality (OR: 0.47; 95%CI: 0.34-0.64) in multivariable-adjusted logistic regression models. Early oral β-blocker use associated reduction in major bleeding was evident both in high-dose (defined by metoprolol-equivalent dose ≥50 mg/day) users (OR: 0.47; 95%CI: 0.33-0.68) and in low-dose users (metoprolol-equivalent dose &lt;50 mg/day; OR: 0.61; 95%CI: 0.47-0.79). No significant difference was observed between metoprolol and bisoprolol in terms of reductions in major bleeding and mortality. Analyses based on inverse-probability-of-treatment-weighted regression adjustment and propensity-score matching yielded consistent findings.

Conclusion
In this retrospective study based on the nationwide ACS registry, among patients treated by PCI, in addition to a reduction in in-hospital mortality, oral β-blocker therapy initiated within the first 24 hours was associated with a reduced risk for major in-hospital bleeds.
Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT02306616
Non-steroidal mineralocorticoid receptor antagonists in cardiorenal disease
Authors: Pandey Arjun K , Bhatt Deepak L , Cosentino Francesco , Marx Nikolaus , Rotstein Ori , Pitt Bertram , Pandey Ambarish , Butler Javed , Verma Subodh 
Published: June 2022

Abstract
Despite existing treatments, patients with heart failure and chronic kidney disease (CKD) remain at high risk for adverse outcomes and progression to end-stage disease. Steroidal mineralocorticoid receptor antagonists (MRAs) such as spironolactone and eplerenone reduce mortality but remain under-prescribed due to the perceived risk of hyperkalaemia and hormonal side effects. The discovery of non-steroidal MRAs represents a major new dimension in cardiorenal disease therapy. Non-steroidal MRAs have high affinity and specificity for the mineralocorticoid receptor (MR) and differ from both steroidal agents and each other with respect to important physiochemical, pharmacodynamic, and pharmacokinetic parameters. Similar to their steroidal counterparts, they have beneficial anti-inflammatory, anti-remodelling, and anti-fibrotic properties in the kidneys, heart, and vasculature. There are several non-steroidal MRAs under development and clinical assessment; of these, only esaxerenone and finerenone are approved for treatment globally. In Japan, esaxerenone is approved for essential hypertension and has been studied in diabetic nephropathy. Compared with steroidal MRAs, finerenone more potently inhibits MR co-regulator recruitment and fibrosis and distributes more evenly between the heart and kidneys. The landmark Phase III trials FIGARO-DKD and FIDELIO-DKD demonstrated that finerenone-reduced major kidney and cardiovascular events on top of maximally tolerated renin–angiotensin–aldosterone system inhibition in patients with CKD associated with Type 2 diabetes. Non-steroidal MRAs are currently under evaluation in heart failure and for synergistic treatment with sodium–glucose contransporter 2 inhibitors. These ground-breaking agents could become an important therapy across the spectrum of cardiorenal disease.
Now you see it! Using wearable cameras to gain insights into the lived experience of cardiovascular conditions
Authors: Nourse Rebecca , Cartledge Susie , Tegegne Teketo , Gurrin Cathal , Maddison Ralph 
Published: June 2022

Abstract
Wearable cameras offer an innovative way to discover new insights into the lived experience of people with cardiovascular conditions. Wearable cameras can be used alone or supplement more traditional research methods, such as interviews and participant observations. This paper provides an overview of the benefits of using wearable cameras for data collection and outlines some key considerations for researchers and clinicians interested in this method. We provide a case study describing a study design using wearable cameras and how the data were used.
The role of mentoring in promoting diversity equity and inclusion in STEM Education and Research
Authors: Marshall Andrea G , Vue Zer , Palavicino-Maggio Caroline B , Neikirk Kit , Beasley Heather K , Garza-Lopez Edgar , Murray Sandra A , Martinez Denise , Crabtree Amber , Conley Zachary C , Vang Larry , Davis Jamaine S , Powell-Roach Keesha L , Campbell Susan , Brady Lillian J , Dal Angyth B , Shao Bryanna , Alexander Stefanie , Vang Nancy , Vue Neng , Vue Mein , Shuler Haysetta D , Spencer Elsie C , Morton Derrick J , Hinton Antentor 
Published: June 2022

Abstract
The success of mentoring derives from active and respectful listening and the willingness to learn and accept opportunities for personal growth. This shapes every trainee and their destined path in science, technology, engineering, and mathematics (STEM). The act of cultivating rapport, asking, and pondering meaningful questions, and receiving constructive feedback are critical to support a productive mentoring relationship. Successful mentoring in STEM can be established and allow mentees, especially underrepresented minorities (URMs), to flourish in an environment where they feel welcomed and supported. However, mentees from underrepresented groups often experience inadequate mentoring due to a mentor's lack of awareness, poor trainings themselves, or lack of understanding of the mentee’s hardships. It is important for mentors and mentees to work together to promote diversity, equity, and inclusion (DEI) in STEM education through creativity, authenticity, and networking. We analyzed data obtained from students who attended a recent workshop that are interested in going to graduate school. Our results show that despite low initial expectations for the workshop, many students were satisfied in the knowledge they gleaned. The future and role of diversity in STEM within these underrepresented groups lies in community support and an important role that they can play in the lives of others through DEI initiatives and throughout their careers all of which involves positive mentoring.
Contrasting Modes of Mitochondrial Genome Evolution in Sister Taxa of Wood-Eating Marine Bivalves (Teredinidae and Xylophagaidae)
Authors: Li Yuanning , Altamia Marvin A , Shipway J Reuben , Brugler Mercer R , Bernardino Angelo Fraga , de Brito Thaís Lima , Lin Zhenjian , da Silva Oliveira Francisca Andréa , Sumida Paulo , Smith Craig R , Trindade-Silva Amaro , Halanych Kenneth M , Distel Daniel L 
Published: June 2022

Abstract
The bivalve families Teredinidae and Xylophagaidae include voracious consumers of wood in shallow-water and deep-water marine environments, respectively. The taxa are sister clades whose members consume wood as food with the aid of intracellular cellulolytic endosymbionts housed in their gills. This combination of adaptations is found in no other group of animals and was likely present in the common ancestor of both families. Despite these commonalities, the two families have followed dramatically different evolutionary paths with respect to anatomy, life history, and distribution. Here, we present 42 new mitochondrial genome sequences from Teredinidae and Xylophagaidae and show that distinct trajectories have also occurred in the evolution and organization of their mitochondrial genomes. Teredinidae display significantly greater rates of amino acid substitution but absolute conservation of protein-coding gene order, whereas Xylophagaidae display significantly less amino acid change but have undergone numerous and diverse changes in genome organization since their divergence from a common ancestor. As with many bivalves, these mitochondrial genomes encode 2 ribosomal RNAs, 12 protein-coding genes, and 22 tRNAs; atp8 was not detected. We further show that their phylogeny, as inferred from amino acid sequences of 12 concatenated mitochondrial protein-coding genes, is largely congruent with those inferred from their nuclear genomes based on 18S and 28S ribosomal RNA sequences. Our results provide a robust phylogenetic framework to explore the tempo and mode of mitochondrial genome evolution and offer directions for future phylogenetic and taxonomic studies of wood-boring bivalves.
De-noising distributed acoustic sensing data using an adaptive frequency–wavenumber filter
Authors: Isken Marius Paul , Vasyura-Bathke Hannes , Dahm Torsten , Heimann Sebastian 
Published: June 2022

Summary
Data recorded by distributed acoustic sensing (DAS) along an optical fibre sample the spatial and temporal properties of seismic wavefields at high spatial density. Often leading to massive amount of data when collected for seismic monitoring along many kilometre long cables. The spatially coherent signals from weak seismic arrivals within the data are often obscured by incoherent noise. We present a flexible and computationally efficient filtering technique, which makes use of the dense spatial and temporal sampling of the data and that can handle the large amount of data. The presented adaptive frequency–wavenumber filter suppresses the incoherent seismic noise while amplifying the coherent wavefield. We analyse the response of the filter in time and spectral domain, and we demonstrate its performance on a noisy data set that was recorded in a vertical borehole observatory showing active and passive seismic phase arrivals. Lastly, we present a performant open-source software implementation enabling real-time filtering of large DAS data sets.
Are sequential compression devices routinely necessary following enhanced recovery after thoracic surgery?
Authors: Abdul Sami Aftab , Anstee Caitlin , Villeneuve Patrick J , Gilbert Sebatien , Seely Andrew J E , Sundaresan Sudhir , Maziak Donna E 
Published: June 2022

Abstract

OBJECTIVES
The prominence of “enhanced recovery after surgery” (ERAS) protocols being adopted in thoracic surgery requires a re-evaluation of mechanical venous thromboembolism (VTE) prophylaxis guidelines. The goal of this study was to assess the role of sequential compression devices (SCD) in the prevention of VTEs such as deep vein thrombosis and pulmonary embolism (PE) in thoracic surgical patients.

METHODS
We identified 200 patients who underwent elective oncological thoracic surgery between December 2018 and December 2020 in 2 cohorts—1 with SCDs and 1 without (i.e. non-SCD). All patients followed a standardized enhanced recovery after surgery (ERAS) protocol. The quality of care provided by SCDs was evaluated by the incidence and severity of postoperative and follow-up VTEs. Cohorts were compared by the Caprini score (CS) and the Charlson Comorbidity Index (CCI) with a two one-sided t-test analysis. Secondary outcomes include perioperative characteristics and follow-up data.

RESULTS
Only 2 patients within the SCD group developed a PE with average CS and CCI metrics, both after hospital discharge and treated with anticoagulants, raising concern over the prophylactic nature of SCDs. The CS (6.9 ± 1.3 and 6.9 ± 1.5; P = 0.96) and the CCI (3.8 ± 2.0 and 4.1 ± 2.6; P = 0.33) for non-SCD and SCD, respectively, did not differ. The two one-sided t-test analysis for CS (P &lt; 0.001) and CCI (P &lt; 0.001) demonstrated equivalence.

CONCLUSIONS
Although larger studies are required to confirm these results, routine SCD use may not be required when implementing ERAS protocols because clinically significant VTE rates were minimal.
Vaccination After SARS-CoV-2 Infection Increased Antibody Avidity Against the Omicron Variant Compared to Vaccination Alone
Authors: LeMaster Cas , Geanes Eric S , Fraley Elizabeth R , Selvarangan Rangaraj , Bradley Todd 
Published: June 2022

Abstract
The SARS-CoV-2 Omicron variant has caused infections among individuals vaccinated or with prior COVID-19, suggesting immune escape. Here, we showed a decrease in binding and surrogate neutralizing antibody responses to the Omicron variant after 2 doses of the Pfizer COVID-19 mRNA vaccine. Individuals recovered from infection before vaccination had higher antibody levels and avidity to the Omicron variant compared to individuals vaccinated without infection. This suggested that COVID-19 infection before vaccination elicited a higher magnitude and affinity antibody response to the Omicron variant, and repeated exposure through infection or vaccine may be required to improve immunity to emerging SARS-CoV-2 variants.
Precision feeding of lactating sows: implementation and evaluation of a decision support system in farm conditions
Authors: Gauthier Raphaël , Largouët Christine , Bussières Dan , Martineau Jean-Philippe , Dourmad Jean-Yves 
Published: June 2022

Abstract
Precision feeding (PF) aims to provide the right amount of nutrients at the right time for each animal. Lactating sows generally receive the same diet, which either results in insufficient supply and body reserve mobilization, or excessive supply and high nutrient excretion. With the help of online measuring devices, computational methods, and smart feeders, we introduced the first PF decision support system (DSS) for lactating sows. Precision (PRE) and conventional (STD) feeding strategies were compared in commercial conditions. Every day each PRE sow received a tailored ration that had been computed by the DSS. This ration was obtained by blending a diet with a high AA and mineral content (13.00 g/kg SID Lys, 4.50 g/kg digestible P) and a diet low in AAs and minerals (6.50 g/kg SID Lys, 2.90 g/kg digestible P). All STD sows received a conventional diet (10.08 g/kg SID Lys, 3.78 g/kg digestible P). Before the trial, the DSS was fitted to farm performance for the prediction of piglet average daily gain (PADG) and sow daily feed intake (DFI), with data from 1,691 and 3,712 lactations, respectively. Sow and litter performance were analyzed for the effect of feeding strategy with ANOVA, with results considered statistically significant when P &lt; 0.05. The experiment involved 239 PRE and 240 STD sows. DFI was similarly high in both treatments (PRE: 6.59, STD: 6.45 kg/d; P = 0.11). Litter growth was high (PRE: 2.96, STD: 3.06 kg/d), although it decreased slightly by about 3% in PRE compared to STD treatments (P &lt; 0.05). Sow body weight loss was low, although it was slightly higher in PRE sows (7.7 vs. 2.1 kg, P &lt; 0.001), which might be due to insufficient AA supply in some sows. Weaning to estrus interval (5.6 d) did not differ. In PRE sows SID Lys intake (PRE: 7.7, STD: 10.0 g/kg; P &lt; 0.001) and digestible P intake (PRE: 3.2, STD: 3.8 g/kg; P &lt; 0.001) declined by 23% and 14%, respectively, and feed cost decreased by 12%. For PRE sows, excretion of N and P decreased by 28% and 42%, respectively. According to these results, PF appears to be a very promising strategy for lactating sows.
Tips for Successful Career Transitions in Breast Imaging
Authors: Perry Hannah , Narayan Anand , Phillips Jordana , Sheth Monica M , Slanetz Priscilla J 
Published: June 2022

Abstract
Whether beginning a new career in breast imaging or switching into a different breast imaging practice for personal or professional advancement, a leadership opportunity, a need to relocate geographically, or simply a better opportunity, it is critical to transition between positions as smoothly as possible. Thoroughly reflecting on your career priorities and goals is essential prior to undertaking any career transition. Once the decision has been made to move to a new position, it is imperative to learn about the dynamics of the new practice and practice environment. Here, we provide suggestions on how to hit the ground running when joining a new breast imaging practice.
14-Year Longitudinal Trajectories of Depressive Symptoms Among Youth With and Without Type 1 Diabetes
Authors: Helgeson Vicki S , Wright Aidan , Vaughn Abigail , Becker Dorothy , Libman Ingrid 
Published: June 2022

AbstractObjectiveThere is evidence that youth with type 1 diabetes are at risk for depression, and depression is a significant risk factor for subsequent psychological and physical health problems. However, it is not clear if/when this depression risk emerges. The goal of this study was to determine if there are differences in levels of depressive symptoms between youth with and without type 1 diabetes that develop over the course of emerging adulthood. We also examined whether adolescent psychosocial variables predicted depressive symptoms during emerging adulthood.MethodsYouth with (n = 132) and without (n = 131) type 1 diabetes were enrolled in the study at average age 12 and followed for 14 years. Depressive symptoms were measured throughout the study. Psychosocial variables of interest were measured during adolescence.ResultsGroup differences in depressive symptoms emerged by study end at average age 26. Depressive symptoms appeared to decline over time for youth without diabetes and to increase over time for youth with diabetes. Parent relationship difficulties increased over adolescence as did peer conflict for the entire cohort. Supportive relationships with parent and peers predicted fewer end of study depressive symptoms (controlling for baseline depressive symptoms)—equally so for both groups.ConclusionsThis study provides evidence that those with type 1 diabetes may be at risk for depressive symptoms many years after diagnosis and after adolescence. Although relational difficulties with parents and peers increase during adolescence, supportive relationships over the course of adolescence may help to mitigate depressive symptoms during young adulthood.
Middle ear neuroendocrine tumor: a case report
Authors: Lachkar Azeddine , Benfadil Drissia , Elayoubi Fahd 
Published: June 2022

Abstract
Neuroendocrine tumors are extremely rare in the middle ear. These tumors represent a spectrum of tumors with a diverse range of molecular abnormalities, functionality and anatomical locations. We present a rare case of middle ear neuroendocrine tumor, review the pathology and differential diagnosis of the tumors, and discuss the management and follow-up of patients with these tumors. We suspect that the middle ear neuroendocrine tumor is underdiagnosed and more cases can be detected through education and personal experience. Treatment is surgical resection, and long follow-up is recommended.
SELF PRUNING 3C is a flowering repressor that modulates seed germination, root architecture, and drought responses
Authors: Moreira Juliene dos Reis , Quiñones Alejandra , Lira Bruno Silvestre , Robledo Jessenia M , Curtin Shaun J , Vicente Mateus H , Ribeiro Dimas M , Ryngajllo Malgorzata , Jiménez-Gómez José M , Peres Lázaro Eustáquio Pereira , Rossi Magdalena , Zsögön Agustin 
Published: June 2022

Abstract
Allelic variation in the CETS (CENTRORADIALIS, TERMINAL FLOWER 1, SELF PRUNING) gene family controls agronomically important traits in many crops. CETS genes encode phosphatidylethanolamine-binding proteins that have a central role in the timing of flowering as florigenic and anti-florigenic signals. The great expansion of CETS genes in many species suggests that the functions of this family go beyond flowering induction and repression. Here, we characterized the tomato SELF PRUNING 3C (SP3C) gene, and show that besides acting as a flowering repressor it also regulates seed germination and modulates root architecture. We show that loss of SP3C function in CRISPR/Cas9-generated mutant lines increases root length and reduces root side branching relative to the wild type. Higher SP3C expression in transgenic lines promotes the opposite effects in roots, represses seed germination, and also improves tolerance to water stress in seedlings. These discoveries provide new insights into the role of SP paralogs in agronomically relevant traits, and support future exploration of the involvement of CETS genes in abiotic stress responses.