bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacogenomics of MDD as a Developing Field: Challenges and Opportunities
Authors: Baune B. 
Published: September 2022

While first gene-drug pairs have emerged to be clinically actionable in the treatment of major depressive disorders (MDD) (e.g., CYP2D6 and TCAs/SSRIs), genomic studies have not yet been successful in identifying replicable and valid biomarkers of pharmacological treatment outcome. While some trials suggest that candidates such as CYP2D6, CYP2C19, CYP1A2, SLC6A4 and HTR2A polymorphisms may improve the prediction of response/remission, these results should be interpreted cautiously and required confirmation in larger samples. This presentation will cover state of the art of pharmacogenomics for MDD as well as the emerging field of pharmacotranscriptomics and functional genomics analyses in MDD. Specifically, pharmacotranscriptomics in combination with genomics may be a promising avenue in overcoming some of the current limitations in treatment response prediction research. More recently, the combined genetic effect of polygenic risk scores has shown promising results in predicting treatment response. Importantly, adequately large and well phenotyped clinical trials are required to be conducted with pharmacogenomics/-transcriptomics prospectively in mind.DisclosureNo significant relationships.
Impact of the covid-19 pandemic on Moroccan health workers who were not on the frontline
Authors: Benallel K. , Nzamba Nzamba D. , Benjelloun R. , Gartoum M. , Kadiri M. 
Published: September 2022

IntroductionSince March2019, successive waves of the COVID-19pandemic have challenged the mental health of frontline healthcare workers, who have been shown in numerous studies to be at increased risk for characterized psychiatric disorders. However, healthcare professionals who were not directly involved in the care of patients withCOVID-19 were often not investigated. In Morocco, the literature dealing with the psychological impact of the pandemic on backline health professionals is still scarce.ObjectivesThe purpose of our survey is to assess the stress, anxiety, and depression of health workers who were not on the front lines of care forCOVID-19 patients.MethodsIt is a survey developed on googleforms and disseminated via social networks targeting groups of health professionals in Morocco, during June2020. We used the DASS21 scale(depression, anxiety and stress scale with21 items). The results were analyzed using the JAMOVI application.Resultsout of80 participants: 54%are men, 56%are aged between 31 and 40years old, 38%have been in practice for less than 5years of exercise, 66%are married, 41%are specialists 36%are residents and 21%are nurses, 44% work in psychiatric ward. Psychiatric symptoms: 64%have worries, 64% tired, 63% irritability, 59% sadness, 53% insomnia and 51% somatic complaints. 6.3%report substance use. DASS-21: 50%of participants have depression (7.5%mild, 26.25%moderate, 11.25%severe, 5%extremely severe), 48.75%have Anxiety (7.5%mild, 25%moderate, 8.25%severe, 7.5%extremely severe) and 30%report Stress (8.75%mild, 15%moderate, 6.25%severe, 0%extremely severe).ConclusionsThe high level of job stress during the early months of the pandemic exposed health workers who were not on the front line of care forCOVID-19 patients to an increased risk of psychological decompensation.DisclosureNo significant relationships.
Eating habits during quarantine: Investigating the role of emotions and loneliness in a sample of adults in Greece
Authors: Savvopoulou N. , Assimakopoulos K. , Gourzis P. , Jelastopulu E. 
Published: September 2022

Introduction
Imposing quarantine as a measure to manage the coronavirus pandemic is a stressful event that is often associated with negative psychological effects. Eating habits seemed to be significantly affected during the quarantine, while strong negative emotions were triggered as the feeling of loneliness increased at the same time.ObjectivesThis study aims to investigate the eating habits of individuals during quarantine and the role of positive and negative emotions and loneliness in shaping these habits.MethodsAn online cross-sectional study was performed using 3 validated scales, EAT-26 (3 subscales: Dieting, Bulimia and Food Preoccupation, Oral Control), Modified Differential Emotions Scale and UCLA Loneliness Scale. Data was collected between April and May 2021 mainly from social media platforms. Statistical analyses included linear regression and mediation analyses.ResultsAbnormal eating habits were detected in 25% of the participants (N= 450, ages 18-74) while the majority reported medium rates of negative/positive emotions and loneliness. Female sex is associated with abnormal eating habits (p=0.010) and mainly dietary behaviors (p=0.029). Negative emotions (p=0.032) and loneliness (p=0.001) seem to be predictive factors of eating habits in general and bulimic behaviors. Negative emotions correlate directly with eating habits. However, we found a significant mediation of loneliness (p=0.032). Furthermore, the observed association between negative emotions and bulimia is partly mediated by loneliness (p=0.018).ConclusionsNegative emotions and loneliness seemed to play an important role in shaping eating habits during quarantine. Multilevel public health interventions are needed to address the negative effects of quarantine and pandemic in general.DisclosureNo significant relationships.
Anxiety and Depression among Patients Admitted at COVID wards of East Avenue Medical Center (EAMC) Using the Validated Filipino Version of the Hospital Anxiety and Depression Scale (HADS-P)
Authors: Guiang F.J. , Gabaon M.A. 
Published: September 2022

Introduction
COVID-19 is a multifaceted disease establishing differences in terms of its occurrence, manner of clinical presentation and disease predilection. While mental health becomes one of the less analyzed aspects, addressing anxiety and depression allows clinicians to provide more patient-centered care in this pandemic era.ObjectivesThis study determined the prevalence of anxiety and depressive symptoms among patients admitted for at least 14 days at COVID wards of East Avenue Medical using the validated Filipino version of the Hospital Anxiety and Depression Scale (HADS-P), and described the socioeconomic, psychosocial, clinical factors affecting its development among COVID-19 patients.Methods

232 patients admitted at COVID ward of East Avenue Medical Center for at least 14 days were included in the study. Participants were interviewed using the validated Filipino version of the Hospital Anxiety and Depression Score (HADS-P) questionnaire. STATA 13.1 was used for data analysis at 95% confidence intervalResults
Anxiety was significantly correlated with hypertension (p= 0.044), diabetes (p= 0.008), employment status (p= 0.038), and with patients who had family members with COVID- 19 (p= 0.033). Depressive symptoms occurred more likely in Chronic Kidney Disease and in COVID-19 suspects. Most participants had a normal HADS-P anxiety (6) and depression (4) median scores. Mild symptoms of anxiety (n=55) and depression (n=30) were noted among participants. The severity of COVID-19 classification was a statistically significant variable for developing anxiety symptoms.ConclusionsIdentifying predictors of developing anxiety and depressive symptoms enables us to develop better strategies in addressing mental health as one of the important aspects of patient management during this pandemic.DisclosureNo significant relationships.
Anxiety symptoms in critically ill COVID-19 survivors and its association with post-discharge health concerns
Authors: Silva B. , Martins S. , Ferreira A.R. , Fernandes J. , Vieira T. , Fontes L. , Reis N. , Braga A. , Coimbra I. , Paiva J.A. , Fernandes L. 
Published: September 2022

IntroductionEvidence suggest that critically ill COVID-19 patients are at higher risk of developing anxiety symptoms, which may be related to or exacerbated by patients concerns regarding their health status and recovery.ObjectivesTo assess anxiety symptoms in critically ill COVID-19 survivors, 1-2 months after hospital discharge and to analyze its association with concerns reported by patients regarding their own health status and recovery.MethodsIn the framework of MAPA prospective research, this preliminary study included COVID-19 patients admitted in the Intensive Care Medicine Department (ICMD) of a University Hospital. Patients were excluded if they had an ICMD length of stay (LoS) ≤24h, terminal illness, major auditory impairment or inability to communicate at the evaluation time. Participants were assessed at a scheduled telephone follow-up appointment, with Generalized Anxiety Disorder Scale (GAD-7). Additional questions were asked to assess the survivors’ post-discharge concerns regarding discrimination against for COVID-19, infection of a family member, re-infection or sequelae related to COVID-19.ResultsEighty-three patients were included (median age=63 years; 63% male) and 24% had anxiety symptoms. Anxiety scores were higher in survivors who reported being afraid of being discriminated against for COVID-19 (30% vs 10%; p=0.034), being re-infected (100% vs 79%; p=0.032) and having sequelae (94% vs 44%; p<0.001).ConclusionsThese findings revealed that anxiety is common in COVID-19 survivors and is associated with post-discharge patients concerns that may limit patient daily living. This study emphasizes the importance of psychological assessment and follow-up of the COVID-19 survivors, in order to support these patients recovery.DisclosureNo significant relationships.
Quality of sleep in Tunisian patients with Multiple Sclerosis during the COVID-19 pandemic
Authors: Safa K. , Farhat N. , Salma S. , Nadia B. , Mariem B.A. , Chokri M. 
Published: September 2022

IntroductionCOVID-19 pandemic has affected human communities around the world, and there is fear that people with chronic diseases such as Multiple sclerosis(MS) are more vulnerable to negative psychological effects.ObjectivesThe aim of the present study was to assess the quality of sleep in patients with (MS) in comparison with healthy controls(HCs), during the COVID-19 pandemic and to identify its associated factors.MethodsThis was a cross-sectional survey study conducted with patients followed at the neurology department of Hbib bourguiba university hospital in sfax(Tunisia), during the month of november2020. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index(PSQI). The PSQI is a questionnaire assessing participants’ sleep quality, sleep duration, and sleep disturbances and their severity during the past month.Participants with a PSQI ≤5 are classified as ‘good sleepers’.ResultsFifty two patients were included in the study. The mean age was 33.69 years(SD=9.21 years)and the sex ratio(F/H)was 4.77. Overall, our patients had higher scores of(PSQI)compared to HC and these différences were statistically significant(p < 0.05). The mean score of(PSQI)was 11.04(SD=3.003)and 11.53%were classified as ‘good sleepers’. Unemployment was related to a poor sleep quality(p=0.0001). Patients with high EDSS(r=0.7;p=0.0001), high number of relapses(r=0.58 ;p=0.0001)were more likely to have sleep disturbance. There was a positive correlation between a poor sleep quality and the duration of disease(r=0.38;p=0.005).ConclusionsWe identified that during the COVID-19pandemic patients with(MS)had a worse sleep quality. The COVID-19pandemic poses a challenge to psychological resilience. More studies are warranted to better understand the long-term consequences of the pandemic on mental health of vulnerable people.DisclosureNo significant relationships.
Vaccine hesitancy among hospital workers
Authors: Abu Shehab A.H.I. , Cruceanu C. , Ciubara A.B. , Gurita A.V. , Luca L. , Ciubara A. 
Published: September 2022

IntroductionVaccine hesitancy is a serious issue and it affects the scientific achievements of health. This phenomenon has begun to be studied more often in health care workers, to find its determining factors.ObjectivesThe aim was to determine the percentage of hospital workers who got vaccinated against the infection with SARS-CoV-2.MethodsBeginning with October 2021, we conducted an online questionnaire in which 57 hospital workers participated. Preliminary results allowed us to assess the rate of vaccine hesitancy among this group.ResultsOut of the 57 hospital workers, the majority were vaccinated (n=45, 78.94%) in comparison to less than a quarter (n=12, 21.05%) that refused vaccination. The group of hospital workers included mostly nurses ( n=21, 36.84%). Also, 12 psychologists (21.05%), 11 doctors (19.29%), and 10 students (17.54%) were included. Among the cases that did not accept getting vaccinated against COVID-19, the highest percentage was occupied by nurses (n=9, 15.78%). Moreover, there were only one doctor and one psychologist who did not get vaccinated.ConclusionsIn the current pandemic times, the hesitancy and refusal of vaccination prove to be very challenging. It is important to explore their reasons and to promote health education programs.DisclosureNo significant relationships.
The Dynamics of Information Search Queries about COVID-19 at the Self-Isolation Stage
Authors: Belinskaya E. , Tihomandritskaya O. , Stolbova E. , Tsikina E. 
Published: September 2022

IntroductionThe dynamics of search queries in large random samples may reflect both the reaction of the population to the statements of power subjects, and the presence of certain mechanisms of emotional self-regulation.ObjectivesStudying the dynamics of information search queries in the situation of experiencing an objective global threat-the spread of COVID-19.MethodsQuantitative methods of the Data Mining class were used for data collection. Qualitative methods of the Data Mining class and contextual analysis were used for data analysis. Search queries related to COVID-19 and the introduction of self-isolation were analyzed: 5 million queries were randomly selected.ResultsThe number of information requests on the topic of the pandemic increased sharply after V. Putin’s first address, and then steadily decreased, but the overall picture of the content dynamics of search queries, depending on official statements of the authorities, was not observed; requests about the current level of morbidity are constantly presented to the greatest extent, and to the minimum-about the possibilities of psychological assistance and the state of the Russian economy. During the whole time of the study the contents of the Internet search shifted towards positive emotional information.Conclusions. To the maximum extent, the relationship between the experience of a pandemic and self-isolation with the nature of search queries manifests itself at the initial stages and tends to decrease in the future. The dynamics of the content of requests is ambiguously related to official statements of power subjects, influenced by the effect of counter-regulation.DisclosureNo significant relationships.
Variable feelings of cohesion, trust, individualism and exclusion and their consequences on Swiss public mental health during the ongoing COVID-19 pandemic
Authors: Kraxner F. 
Published: September 2022

IntroductionThe first cases of COVID-19 in Switzerland were related to the Milan cluster in February 2020. Border crossing restrictions were imposed and economic support measures worth 40 billion Swiss francs were announced. By 24th September 2021 Switzerland achieved a fully vaccination rate of 54%, confirmed 836’000 cases and 11’060 deaths.Objectives
The objective was to describe and analyse the mental health of the general Swiss population under the ongoing COVID-19 pandemic and it’s social changes: including a case description, transgenerational influence and psychosocial treatment opportunitiesMethodsTo answer the research question, I used deepened internet research, population interviews among different age gropus and colloquies with healthcare providers and federal authorities.ResultsDifferent psychosocial phenomena lead to the transgenerational influence. Unfortunately, vaccination rate is slowed down by this pandemic’s impacts on public mental health. While during the first wave the positive feelings of cohesion and trust dominated, the mood changed afterwards to anxiousness and reactive individualism. Among all generations the fear of infection was shown to be a general booster of anxiety and distress. In fact, Swiss experts perceive the corona crisis as a catalysator for depression and anxiety disorders.ConclusionsSpecific psychosocial treatment has to address general and individual vulnerability factors. However, staying in touch with family members, pursuing meaningful activities and being physically active can all help to overcome COVID-19 related mental health issues.DisclosureNo significant relationships.
Post-traumatic stress symptoms and professional quality of life among healthcare professionals working in COVID departments
Authors: Elleuch O. , Feki R. , Smaoui N. , Gassara I. , Maalej M. , Omri S. , Charfi N. , Zouari L. , Ben Thabet J. , Maalej M. 
Published: September 2022

IntroductionThe COVID pandemic had a heavy impact on the mental health of people in general and healthcare professionals in particular.ObjectivesOur study aimed to examine the the prevalence of post-traumatic stress symptoms among healthcare professionals working in COVID departments, and assess their professional quality of life.MethodsOur sample consisted of 23 healthcare professionals who are working in the COVID departments of the Hospitals of Sfax. We collected their sociodemographic data, their medical history and COVID-related details. Their mental health was assessed by the Impact of Event scale (IES-R) and the professional quality of life scale (ProQOL-5)Results
The sex ratio in our study was 17:6, with a mean age of 31.79 years. They carried out 5.43 nightshifts per month, 57 hours of work per week including 27.38 hours of direct contact with COVID positive patients. A rate of 21.74% of the patients had a high IES-R score, indicating severe post traumatic stress symptoms. As for the subscales of the professional quality of life score, 21.73% of the participants had a low compassion satisfaction score, 65.21% of the participants had a moderate one and 13% had a high one. A rate of 91.3% of the participants had a moderate burnout score, the mean was 29.39. The secondary traumatization score was low in 26% of the cases, moderate in 60.86%, high in 13% and the mean was 27.91.Conclusions
COVID healthcare professionals are at a relatively high risk of developing burnout and post-traumatic stress symptoms.DisclosureNo significant relationships.
Suicide Prevention in Patients with Severe Mental Disorders
Authors: Courtet P. 
Published: September 2022

Until 2016, only few interventions were supposed to work in suicide prevention: restriction of access to lethal means, school-based universal prevention, treatment of depression and ensuring chain of care. Then, despite the multiplication of the therapeutic strategies for psychiatric disorders during the last decades, the incidence of suicide has not substantially decreased. Among several hypotheses, we proposed that suicidal depression is a specific form of depression, less responsive to antidepressants, carrying a high suicide risk, which deserves specific interventions. During the last decade, few controlled studies have been performed in at risk patients with short term reduction of the risk of suicide as a main objective, and the interest for old drugs such as lithium and clozapine remains. Recent data allow to propose that a new era is coming with evidence-based strategies of suicide prevention that should lead to change the way we deal with suicidal patients. Importantly, most efforts to develop interventions have moved to a perspective that suicide- specific treatments are necessary in addition to interventions for primary psychiatric disorders. By formulating the hypothesis that suicidal patients present a dysregulated response to social adversity based on specific brain areas associated with psychological pain, relying to opioidergic, immune and glutamatergic systems. Last, due to the difficult management of suicidal patients, innovative psychosocial interventions should be implemented for patients in suicidal crises and including safety planning, coordination of care, brief contact using phone calls. We have probably more solutions than ever to prevent suicide.DisclosureNo significant relationships.
High Resolution Covid Program. Purposely a case
Authors: Ogando Portilla N. , Bañón González S.M. , Martínez Cortés M. , Agudo Urbanos M. , Gutiérrez Labrador R. 
Published: September 2022

IntroductionThe covid pandemic has become a unique phenomenon in world history with great impact on mental health.ObjectivesA great growth of anxious depressive pathology in relation to the Covid situation has appeared with the need to increase the psychiatric approach in the general populationMethodsA 58-year-old woman with no personal medical story of interest is referred to the high-resolution Covid program due to severe depressive symptoms: intense apathy, abulia, anhedonia, weight loss, insomnia and important social distancing after the beginning of the confinement due to the Covid Pandemic. 4 psychotherapy sessions are performed, with a maximum duration of 45 minutes. It is necessary to add antidepressant medication with sertraline up to 100mg to improve psychotherapeutic work.ResultsA complete recovery of symptoms is achieved even their severity with normalization of daily life.ConclusionsSmall psychotherapeutic interventions have been shown, even with critically ill patients, to be very effective in helping patients regain their baseline status.DisclosureNo significant relationships.
Impact of the Covid-19 pandemic on people with a pre-existing psychiatric disorder
Authors: Khouadja S. , Asgharzadeh M. , Younes S. , Zarrouk L. 
Published: September 2022

IntroductionThe Covid-19 pandemic has had a deleterious impact on populations across the world. Yet it remains unclear how this pandemic is affecting the psychological health of people with a previous history of mental illness.ObjectivesThis study aims to investigate the impact of Covid-19 on patients with established mental disorders.MethodsThe PubMed and science direct databases were systematically searched using the keywords combination “Covid-19” and “psychiatric disorders”, “the pandemic” and “mental disorders “, from inception up to November 2021. We adopted a broad inclusion criterion for the study requiring patients to have a pre-existing mental disorder, excluding narrative reviews and preclinical studies. In addition, a search of google scholar was conducted to identify any additional relevant publications.ResultsWe have found 26 studies but only 19 met our inclusion criteria. Included studies were published between 2020 and 2021. 2 major results were identified. Symptoms deterioration was reported in individuals with severe mental disorders and those with schizophrenia in particular, such as depressive or anxiety symptoms, substance use and suicidal ideation, due to the psychological stress and physical distancing measures associated with the Covid-19 outbreak. The symptomatic treatments used in Covid-19 had frequent interactions with the most used antipsychotic drugs leading to a substantial increase in relapse rates in people with mental disorders.ConclusionsThe Covid-19 pandemic has a serious impact on individuals with pre-existing mental illness reinforcing symptom severity and psychological stress. Additional studies are needed to strengthen current findings with pre-pandemic records.DisclosureNo significant relationships.