bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative study of v-ring indenter configurations in fineblanking in order to derive tool design guidelines
Authors: Nürnberger Anian , Müller Daniel , Martinitz Lukas , Hartmann Christoph , Tobie Thomas , Stahl Karsten , Volk Wolfram 
Published: November 2022

AbstractThe v-ring indenters and their configurations play a major role in the fineblanking process, directly influencing component quality and characteristics. While past studies regarding residual stresses of blanked components focused mainly on the use of a pair of v-rings, so far no efforts were undertaken to compare different v-ring setups, deducing tool design guidelines and enabling possible cost savings. Therefore, a comparative study of different v-ring indenter setups and their influence on cut surface parameters, surface hardness and induced residual stresses of the produced components was performed. The obtained results indicate a minor influence of blank holder-sided v-rings on the observed component characteristics in comparison to indenters situated on the die leading to recommendations with regard to cost-efficient tool design.
Projector matrix product operators, anyons and higher relative commutants of subfactors
Authors: Kawahigashi Yasuyuki 
Published: November 2022

AbstractA bi-unitary connection in subfactor theory of Jones producing a subfactor of finite depth gives a 4-tensor appearing in a recent work of Bultinck–Mariën–Williamson–Şahinoğlu-Haegeman–Verstraete on two-dimensional topological order and anyons. In their work, they have a special projection called a projector matrix product operator. We prove that the range of this projection of lengthkis naturally identified with thekth higher relative commutant of the subfactor arising from the bi-unitary connection. This gives a further connection between two-dimensional topological order and subfactor theory.
A theoretical study of dynamic processes observed in trimethylsilyl-1H-pyrazoles: prototropy and silylotropy
Authors: Claramunt Rosa M. , Elguero José , Alkorta Ibon 
Published: November 2022

AbstractThe 1H, 13C, 15N and 29Si chemical shifts of three trimethylsilyl-1H-pyrazoles were calculated and compared with literature results; the calculations were carried out at the GIAO/B3LYP/6–311 +  + G(d,p) level resulting in a very good agreement that allows to predict with confidence the missing experimental values. The prototropic barrier of 4-trimethylsilyl-1H-pyrazole (1) as well as the silylotropic barriers of 1-trimethylsilyl-1H-pyrazole (2) and 1-trimethylsilyl-4-methyl-1H-pyrazole (3) were also calculated and the mechanism was established, the accordance with the experimental values being satisfactory.
Global Well-Posedness for $$H^{-1}(\mathbb {R})$$ Perturbations of KdV with Exotic Spatial Asymptotics
Authors: Laurens Thierry 
Published: November 2022

AbstractGiven a suitable solution V(t, x) to the Korteweg–de Vries equation on the real line, we prove global well-posedness for initial data $$u(0,x) \in V(0,x) + H^{-1}(\mathbb {R})$$

u

(
0
,
x
)

∈
V

(
0
,
x
)

+

H

-
1

(
R
)

. Our conditions on V do include regularity but do not impose any assumptions on spatial asymptotics. We show that periodic profiles $$V(0,x)\in H^5(\mathbb {R}/\mathbb {Z})$$

V

(
0
,
x
)

∈

H
5

(
R
/
Z
)

satisfy our hypotheses. In particular, we can treat localized perturbations of the much-studied periodic traveling wave solutions (cnoidal waves) of KdV. In the companion paper Laurens (Nonlinearity. 35(1):343–387, 2022. https://doi.org/10.1088/1361-6544/ac37f5) we show that smooth step-like initial data also satisfy our hypotheses. We employ the method of commuting flows introduced in Killip and Vişan (Ann. Math. (2) 190(1):249–305, 2019. https://doi.org/10.4007/annals.2019.190.1.4) where $$V\equiv 0$$

V
≡
0

. In that setting, it is known that $$H^{-1}(\mathbb {R})$$

H

-
1

(
R
)

is sharp in the class of $$H^s(\mathbb {R})$$

H
s

(
R
)

spaces.
Nomogram based on MRI for preoperative prediction of Ki-67 expression in patients with intrahepatic mass cholangiocarcinoma
Authors: Chen Xiang , Zhu Jingfen , Zou Zigui , Du Mingzhan , Xie Junjian , Ye Yujie , Zhang Ling , Li Yonggang 
Published: November 2022

Abstract
Objectives
To validate a new nomogram based on magnetic resonance imaging (MRI) for pre-operative prediction of Ki-67 expression in patients with intrahepatic mass cholangiocarcinoma (IMCC).

Methods
A total of 78 patients with clinicopathologically confirmed IMCC who underwent pre-operative gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid enhanced MRI between 2016 and 2022 were enrolled in the training and validation group (53 patients and 25 patients, respectively). Images including qualitative, quantitative MRI features and clinical data were evaluated. Univariate analysis and multivariate logistic regression were used to select the independent predictors and establish different predictive models. The predictive performance was validated by operating characteristic curve (ROC) analysis, calibration curve, and decision curve analysis (DCA). The validation cohort was used to test the predictive performance of the optimal model. The nomogram was constructed with the optimal model.

Results
In the training cohort, independent predictors obtained from the combined model were DWI (OR 1822.741; 95% CI 6.189, 536,781.805; P = 0.01) and HBP enhancement pattern (OR 14.270; 95% CI 1.044, 195.039; P = 0.046). The combined model showed the good performance (AUC 0.981; 95% CI 0.952, 1.000) for predicting Ki-67 expression. In the validation cohort, The combined model (AUC 0.909; 95% CI 0.787, 1.000)showed the best performance compared to the clinical model (AUC 0.448; 95% CI 0.196, 0.700) and MRI model (AUC 0.770; 95% CI 0.570, 0.970).

Conclusion
This new nomogram has a good performance in predicting Ki-67 expression in patients with IMCC, which could help the decision-making of the patients’ therapy strategies.

Graphical abstract
Outcome of patients with idiopathic ventricular fibrillation and correlation with ECG markers of early repolarization
Authors: Rath Benjamin , Willy Kevin , Ellermann Christian , Leitz Patrick , Köbe Julia , Reinke Florian , Lange Philipp Sebastian , Frommeyer Gerrit , Eckardt Lars 
Published: November 2022

Abstract
Background
Early repolarization pattern (ERP) has been associated with idiopathic ventricular fibrillation (IVF) and with cardiovascular mortality in the general population. As there is limited data about long- term outcome of IVF, the aim of our study was to observe ventricular arrhythmia (VA) recurrences in these patients and to identify a possible correlation of VA with ECG markers of early repolarization.

Methods and results
We investigated 56 consecutive IVF patients who received an implantable cardioverter-defibrillator for secondary prevention. ERP was defined as a J-point elevation ≥ 0.1 mV in two or more contiguous inferior or lateral leads. Markers of early repolarization were present in 32.1% of cases with a preponderance of QRS slurring (77.8%). During a mean follow-up of 41.2 months, 11 patients (19.6%) received in total 18 adequate ICD-therapies. VF was most the common cause for ICDtherapy (61.1%) but monomorphic VT also occurred in four patients. Presence of ERP was associated with a significant trend towards arrhythmia recurrences. 38.9% patients with ERP received appropriate ICD-therapies whereas only 10.5% of patients without ERP had arrhythmia recurrence (p = 0.05). Inappropriate ICD-therapies occurred in seven patients (12.5%) with a non-significant trend towards a higher incidence in patients with a transvenous ICD (p = 0.15).

Conclusion
A significant correlation between ERP and VA recurrences in patients with IVF could be observed. Though monomorphic VA also play a role in the studied IVF-population, our data support the use of the S-ICD in this collective.

Graphical abstract
Proteomics uncover EPHA2 as a potential novel therapeutic target in colorectal cancer cell lines with acquired cetuximab resistance
Authors: Torlot Lucien , Jarzab Anna , Albert Johanna , Pók-Udvari Ágnes , Stahler Arndt , Holch Julian Walter , Gerlinger Marco , Heinemann Volker , Klauschen Frederick , Kirchner Thomas , Kumbrink Jörg , Küster Bernhard , Jung Andreas 
Published: November 2022

Abstract
Background
In metastatic colorectal cancer (mCRC), acquired resistance against anti-EGFR targeted monoclonal antibodies, such as cetuximab (CET), was shown to be frequently caused by activating alterations in the RAS genes KRAS or NRAS. To this day, no efficient follow-up treatment option has emerged to treat mCRC in such a setting of resistance.

Methods
To uncover potential targets for second-line targeted therapies, we used mass-spectrometric proteomics to shed light on kinome reprogramming in an established cellular model of acquired, KRAS-associated CET resistance.

Results
This CET resistance was reflected by significant changes in the kinome, most of them individual to each cell line. Interestingly, all investigated resistant cell lines displayed upregulation of the Ephrin type-A receptor 2 (EPHA2), a well-known driver of traits of progression. Expectedly resistant cell lines displayed increased migration (p < 0.01) that was significantly reduced by targeting the EPHA2 signalling axis using RNA interference (RNAi) (p < 0.001), ephrin-A1 stimulation (p < 0.001), dasatinib (p < 0.01), or anti-EPHA2 antibody treatment (p < 0.001), identifying it as an actionable target in mCRC with acquired CET resistance.

Conclusion
These results highlight EPHA2 and its role in mCRC with KRAS-gene mutated acquired CET resistance and support its use as a potential actionable target for the development of future precision medicine therapies.
Combined anterior and posterior approach in treatment of ankylosing spondylitis-associated cervical fractures: a systematic review and meta-analysis
Authors: Chen Hua-Jian , Chen De-Yuan , Zhou Shao-zhen , Sang Li-li , Wu Jun-zhe , Huang Fu-li 
Published: November 2022

Abstract
Objective
Cervical fractures with ankylosing spondylitis (CAS) are a specific type of spinal fracture with poor stability, low healing rate, and high disability rate. Its treatment is mainly surgical, predominantly through the anterior approach, posterior approach, and the anterior–posterior approach. Although many clinical studies have been conducted on various surgical approaches, controversy still exists concerning the choice of these surgical approaches by surgeons. The authors present here a systematic evaluation and meta-analysis exploring the utility of the anterior–posterior approach versus the anterior approach and the posterior approach.

Methods
After a comprehensive literature search of PubMed, Cochrane, Web of Science, and Embase databases, 12 clinical studies were included in the final qualitative analysis and 8 in the final quantitative analysis. Of these studies, 11 conducted a comparison between the anterior–posterior approach and the anterior approach and posterior approaches, while one examined only the anterior–posterior approach. Where appropriate, statistical advantage ratios and 95% confidence intervals were calculated.

Results
The present meta-analysis of postoperative neurological improvement showed no statistical difference in the overall neurological improvement rate between the anterior–posterior approach and anterior approach (OR 1.70, 95% CI 0.61 to 4.75; p = 0.31). However, the mean change in postoperative neurological function was lower in patients who received the anterior approach than in those who received the anterior–posterior approach (MD 0.17, 95% CI -0.02 to 0.36; p = 0.08). There was an identical trend between the anterior–posterior approach and posterior approach, with no statistically significant difference in the overall rate of neurological improvement (OR 1.37, 95% CI 0.70 to 2.56; p = 0.38). Nevertheless, the mean change in neurological function was smaller in patients receiving the anterior–posterior approach compared with the posterior approach, but there was no statistically significant difference between the two (MD 0.17, 95% CI -0.02 to 0.36; p = 0.08).

Conclusions
The results of this review and meta-analysis suggest that the benefits of the anterior–posterior approach are different from those of the anterior and posterior approaches in the treatment of ankylosing spondylitis-related cervical fractures. In a word, there is no significant difference between the cervical surgical approach and the neurological functional improvement. Therefore, surgeons should pay more attention to the type of cervical fracture, the displacement degree of cervical fracture, the spinal cord injury, the balance of cervical spine and other aspects to comprehensively consider the selection of appropriate surgical methods.
Variation in attitudes toward diagnosis and medication of ADHD: a survey among clinicians in the Norwegian child and adolescent mental health services
Authors: Lyhmann Ingvild , Widding-Havneraas Tarjei , Zachrisson Henrik Daae , Bjelland Ingvar , Chaulagain Ashmita , Mykletun Arnstein , Halmøy Anne 
Published: November 2022

AbstractPrevalence and medication rates of ADHD vary geographically, both between and within countries. No absolute cutoff exists between ADHD and normal behavior, making clinician attitudes (leading to local practice cultures) a potential explanation for the observed variation in diagnosis and medication rates. The objective of this study was to describe variation in attitudes toward diagnosis and medication of ADHD among clinicians working in child and adolescent mental health services (CAMHS). We hypothesized that attitudes would vary along a spectrum from “restrictive” to “liberal”. We also explored whether differences in attitudes between clinicians were related to professional background and workplace (clinic). A survey in the form of a web-based questionnaire was developed. All CAMHS outpatient clinics in Norway were invited. Potential respondents were all clinicians involved in diagnosing and treating children and adolescents with ADHD. To investigate the existence of attitudes toward diagnosis and medication as latent constructs, we applied confirmatory factor analysis (CFA). We further examined how much of variance in attitudes could be ascribed to profession and clinics by estimating intraclass correlation coefficients. In total, 674 respondents representing 77 (88%) of the clinics participated. We confirmed variation in attitudes with average responses leaning toward the “restrictive” end of the spectrum. CFA supported “attitude toward diagnosis” and “attitude toward medication” as separate, and moderately correlated (r = 0.4) latent variables, representing a scale from restrictive to liberal. Professional background and workplace explained only a small part of variance in these attitudes.
Design and evaluation of a collaborative UML modeling environment in virtual reality
Authors: Yigitbas Enes , Gorissen Simon , Weidmann Nils , Engels Gregor 
Published: November 2022

AbstractModeling is a key activity in conceptual design and system design. Through collaborative modeling, end-users, stakeholders, experts, and entrepreneurs are able to create a shared understanding of a system representation. While the Unified Modeling Language (UML) is one of the major conceptual modeling languages in object-oriented software engineering, more and more concerns arise from the modeling quality of UML and its tool-support. Among them, the limitation of the two-dimensional presentation of its notations and lack of natural collaborative modeling tools are reported to be significant. In this paper, we explore the potential of using virtual reality (VR) technology for collaborative UML software design by comparing it with classical collaborative software design using conventional devices (desktop PC/laptop). For this purpose, we have developed a VR modeling environment that offers a natural collaborative modeling experience for UML Class Diagrams. Based on a user study with 24 participants, we have compared collaborative VR modeling with conventional modeling with regard to efficiency, effectiveness, and user satisfaction. Results show that the use of VR has some disadvantages concerning efficiency and effectiveness, but the user’s fun, the feeling of being in the same room with a remote collaborator, and the naturalness of collaboration were increased.
Bone-related behaviours of captive chimpanzees (Pan troglodytes) during two excavating experiments
Authors: Motes-Rodrigo Alba , Tennie Claudio , Hernandez-Aguilar R. Adriana 
Published: November 2022

AbstractAfter stone tools, bone tools are the most abundant artefact type in the Early Pleistocene archaeological record. That said, they are still relatively scarce, which limits our understanding of the behaviours that led to their production and use. Observations of extant primates constitute a unique source of behavioural data with which to construct hypotheses about the technological forms and repertoires exhibited by our hominin ancestors. We conducted two different experiments to investigate the behavioural responses of two groups of captive chimpanzees (Pan troglodytes; n = 33 and n = 9) to disarticulated, defleshed, ungulate bones while participating in a foraging task aimed at eliciting excavating behaviour. Each chimpanzee group was provided with bone specimens with different characteristics, and the two groups differed in their respective experience levels with excavating plant tools. We found that several individuals from the inexperienced group used the provided bones as tools during the task. In contrast, none of the individuals from the experienced group used bones as excavating tools, but instead continued using plant tools. These chimpanzees also performed non-excavating bone behaviours such as percussion and tool-assisted extraction of organic material from the medullary cavity. Our findings serve as a proof-of-concept that chimpanzees can be used to investigate spontaneous bone tool behaviours such as bone-assisted excavation. Furthermore, our results raise interesting questions regarding the role that bone characteristics, as well as previous tool-assisted excavating experience with other raw materials, might have in the expression of bone tool-assisted excavation.
Low prevalence of haemosporidian and trypanosome infections in the Eurasian Nightjar (Caprimulgus europaeus)
Authors: Dubiec Anna , Da Silva Arnaud , Celej Marta 
Published: November 2022

AbstractResearch on the occurrence and community composition of vector-transmitted protozoan haemoparasites in birds is heavily skewed toward passerines with many other orders underrepresented. In caprimulgids, a family of primarily ground-nesting, crepuscular/nocturnal birds occupying a wide range of dry habitats, research on protozoan haemoparasites is limited and in most cases based on only a few individuals. Here, using the molecular approach, the occurrence and diversity of parasites from four genera (Haemosporida:Haemoproteus,Plasmodium,Leucocytozoon; Trypanosomatida:Trypanosoma) were investigated in a representative of the family—the Eurasian Nightjar (Caprimulgus europaeus). Birds were sampled at a breeding location in south-eastern Poland at the beginning of the breeding season. Overall, 20 individuals, including 17 males and 3 females, were screened. Only 10% of birds were infected and in total, two parasite lineages—both representingPlasmodiumgenus—were identified. Detected parasite lineages were previously registered in a wide range of avian hosts. Known transmission areas of these lineages indicate that breeding populations of Eurasian Nightjars from south-eastern Poland contract infections on non-breeding grounds. This study reinforces earlier observations of the low prevalence of haemosporidians and trypanosomes in caprimulgids.
Sexual reproduction in two mixed stands of coastal and interior Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco) in Germany
Authors: Pakull Birte , Wojacki Janine , Eusemann Pascal , Fussi Barbara , Ahnert Diana , Liesebach Heike 
Published: November 2022

AbstractAdult individuals and seeds of two mixed stands of coastal and interior Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco) were analysed for genetic differentiation between the two varieties and evidence of intervarietal pollination. Clear genetic discrimination between the two varieties was observed based on multilocus evaluation of nine microsatellite markers using other Douglas-fir stands of known variety composition for comparison. Analysis of pollination distances showed that 80% of pollinations took place within a distance of about 44–55 m. Analysis of stand structure showed clearly separated areas of mainly coastal or interior Douglas-fir within both stands. Together with short pollination distances this led to an apparent dominance of intravarietal pollinations. However, analysis of pollination partners of trees growing near the border of the variety specific areas, does not indicate the existence of reproductive barriers between trees of the two varieties growing in mixed stands. Therefore, commercial seed harvesting in mixed stands should be avoided if the production of seed lots of pure coastal or interior Douglas-fir is intended.
First-line nivolumab plus ipilimumab or chemotherapy versus chemotherapy alone in advanced esophageal squamous cell carcinoma: a Japanese subgroup analysis of open-label, phase 3 trial (CheckMate 648/ONO-4538-50)
Authors: Kato Ken , Doki Yuichiro , Ogata Takashi , Motoyama Satoru , Kawakami Hisato , Ueno Masaki , Kojima Takashi , Shirakawa Yasuhiro , Okada Morihito , Ishihara Ryu , Kubota Yutaro , Amaya-Chanaga Carlos , Chen Tian , Matsumura Yasuhiro , Kitagawa Yuko 
Published: November 2022

Abstract
Background
Programmed cell death 1 (PD-1)-based treatments are approved for several cancers. CheckMate 648, a global, phase 3 trial, showed that first-line nivolumab (anti-PD-1 antibody) plus ipilimumab (NIVO + IPI) or nivolumab plus chemotherapy (NIVO + Chemo) significantly increased survival in advanced esophageal squamous cell carcinoma (ESCC) without new safety signals versus chemotherapy alone (Chemo).

Methods
We evaluated the Japanese subpopulation of CheckMate 648 (n = 394/970), randomized to receive first-line NIVO + IPI, NIVO + Chemo, or Chemo. Efficacy endpoints included overall survival (OS) and progression-free survival assessed by blinded independent central review in Japanese patients with tumor-cell programmed death-ligand 1 (PD-L1) expression ≥ 1% and in all randomized Japanese patients.

Results
In the Japanese population, 131, 126, and 137 patients were treated with NIVO + IPI, NIVO + Chemo, and Chemo, and 66, 62, and 65 patients had tumor-cell PD-L1 ≥ 1%, respectively. In patients with tumor-cell PD-L1 ≥ 1%, median OS was numerically longer with NIVO + IPI (20.2 months; hazard ratio [95% CI], 0.46 [0.30–0.71]) and NIVO + Chemo (17.3 months; 0.53 [0.35–0.82]) versus Chemo (9.0 months). In all randomized patients, median OS was numerically longer with NIVO + IPI (17.6 months; 0.68 [0.51–0.92]) and NIVO + Chemo (15.5 months; 0.73 [0.54–0.99]) versus Chemo (11.0 months). Grade 3–4 treatment-related adverse events were reported in 37%, 49%, and 36% of all patients in the NIVO + IPI, NIVO + Chemo, and Chemo arms, respectively.

Conclusion
Survival benefits with acceptable tolerability observed for NIVO + IPI and NIVO + Chemo treatments strongly support their use as a new standard first-line treatment in Japanese patients with advanced ESCC.

ClinicalTrials.gov ID
NCT03143153.