bluuebunny/crossref_metadata_2025_split huggingface dataset:
SLC6A14 promotes cell migration and inhibits autophagy in gastric cancer by regulating JAK2/STAT3 signaling
Authors: Wang Haifeng , Wang Jindao 
Published: August 2022

Purpose: To investigate the role of solute carrier family 6-member 14 (SLC6A14) in gastric cancer (GC) tumorigenesis.Methods: The GC cell proliferation was evaluated by CCK8 and colony formation assays. Flow cytometry and wound healing assays were used to investigate cell apoptosis and migration, respectively. Immunofluorescence was used to investigate autophagy.Results: The SLC6A14 was elevated in GC cells (p < 0.001). Overexpression of SLC6A14 increased GC cell viability and migration (p < 0.001), increased colony formation, and suppressed cell apoptosis (p < 0.05). However, knockdown of SLC6A14 inhibited GC tumorigenesis by decreasing cell viability and migration, reducing colony formation, and promoting cell apoptosis (p < 0.001). Overexpression of SLC6A14 decreased the LC3-II/LC3-I ratio. Silencing of SLC6A14 increased the LC3-II/LC3-I ratio and increased the fluorescence intensity of LC3. Overexpression of SLC6A14 increased phosphorylation of JAK2 and STAT3 (p < 0.001).Conclusion: Knockdown of SLC6A14 suppresses GC cell migration and proliferation and promotes autophagy through inactivation of JAK2/STAT3 signaling.
The Impact of Behavioral Nudging in Economic Theory on High School Grading Policies and Student Achievement
Authors: Parikh-Briggs Alexander , Nair Suraj , Sharma Prakriti 
Published: August 2022

This research paper examines the implications of neoclassical economic theory and behavioral economic nudges on high school teachers' grading policies and the motivation and academic achievement of students. I further develop the literature in education economics to investigate various grading policies chosen by teachers and the impact on student motivation and educational outcomes. I highlight teacher preferences which include a traditional grading policy or five-point system, using the letters A-E/F. On the other hand, students prefer grading systems that evaluate what they are learning, allow for effort-based achievement, and consider classroom participation, as opposed to homework and exam scores alone. I examine the benefits and detriments of different grading policies within my high school, Menlo-Atherton High School including traditional grading, standards-based grading (SBG) and pass-fail grading. First, I review the current literature and analyze the major differences between the approaches of neoclassical versus behavioral economics including nudges. Specifically, I examine factors that contribute to a student’s academic achievement and review the literature on grading. Second, I focus on student behavior and motivation that help to incentivize greater academic achievement. Third, I interview several teachers to characterize their grading policy and overall student motivation. Last, I compare the student and teacher findings and the associated behavior and motivation. Overall, my findings and analysis appear to support directionally that a new educational policy focused on a standards-based grading (SBG) policy combined with various behavioral nudges impact student decisions, motivate high school students, and improve educational outcomes.
PELATIHAN DAN PENDAMPINGAN PEMBERDAYAAN SANTRI MILENIAL DALAM PEMBUATAN KERAJINAN TANGAN BERBASIS KEARIFAN LOKAL PADA MASA PANDEMI COVID-19
Authors: Farikhin Fikri 
Published: August 2022

Abstrak:
Di masa pandemi Covid-19 ini, masyarakat Indonesia merasakan dampaknya, mulai dari berbagai aspek seperti aspek ekonomi, aspek kesehatan, aspek pendidikan, dan aspek- aspek lainnya. Dengan adanya dampak ini, mengakibatkan perubahan kebiasaan masyarakat Indonesia yang sebelumnya tidak pernah dilakukan, sehingga mereka harus membuat sebuah kebiasaan baru atau biasa disebut dengan Era New Normal. Pendekatan yang digunakan adalah ABCD dalam melakukan pemberdayaan masyarakat. Di dalam pemberdayaan ini komunitas yang diberdayakan dan dikembangkan adalah di komunitas santri MA Ar-Rohmah Suren Jember. Pemberdayaan di Komunitas Lembaga MA Ar–Rohmah Suren pada masa pandemi Covid-19 menggunakan pendekatan ABCD. Pemberdayaan di komunitas ini difokuskan kepada pengembangan kualitas asset SDM Komunitas melalui Kreatifitas dan pemanfaatan Sumber daya Alam. Pengembangan asset tersebut didasarkan pada kebutuhan yang diharapkan oleh komunitas tersebut dalam menghadapi pandemi covid-19 dengan berbagai solusi untuk permasalahan perekonomian baik di lembaga komunitas maupun di masyarakat luar.
Kata Kunci: Santri Milenial, Kerajinan Tangan, Kearifan Lokal
The Effects of Social and Demographic Factors on High-Volume Hospital and Surgeon Care in Shoulder Arthroplasty
Authors: Testa Edward J. , Brodeur Peter G. , Kim Kang Woo , Modest Jacob M. , Johnson Cameron W. , Cruz Aristides I. , Gil Joseph A. 
Published: August 2022

Introduction:
This study seeks to evaluate (1) the relationship between hospital and surgeon volumes of shoulder arthroplasty and complication rates and (2) patient demographics/socioeconomic factors that may affect access to high-volume shoulder arthroplasty care.

Methods:
Adults older than 40 years who underwent shoulder arthroplasty between 2011 and 2015 were identified in the New York Statewide Planning and Research Cooperative System database using International Classification of Disease 9/10 and Current Procedural Terminology codes. Medical/surgical complications were compared across surgeon and facility volumes. The effects of demographic factors were analyzed to determine the relationship between such factors and surgeon/facility volume in shoulder arthroplasty.

Results:
Seven thousand seven hundred eighty-five patients were included. Older, Hispanic/African American, socially deprived, nonprivately insured patients were more likely to be treated by low-volume facilities. Low-volume facilities had higher rates of readmission, urinary tract infection, renal failure, pneumonia, and cellulitis than high-volume facilities. Low-volume surgeons had patients with longer hospital lengths of stay.

Discussion:
Important differences in patient socioeconomic factors exist in access to high-volume surgical care in shoulder arthroplasty, with older, minority, and underinsured patients markedly more likely to receive care by low-volume surgeons and facilities. This may highlight an area of potential focus to improve access to high-volume care.
Total Knee Arthroplasty After Genicular Nerve Radiofrequency Ablation: Reduction in Prolonged Opioid Use Without Increased Postsurgical Complications
Authors: Stake Seth , Agarwal Amil R. , Coombs Stefan , Cohen Jordan S. , Golladay Gregory J. , Campbell Joshua C. , Thakkar Savyasachi C. 
Published: August 2022

Introduction:
Genicular nerve radiofrequency ablation (GNRFA) is an increasingly used nonsurgical treatment modality for patients with advanced knee osteoarthritis. Previous studies have demonstrated this to be an effective and safe method to decrease pain and increase functionality in this patient population. The purpose of this study was to compare 2-year postoperative complication rates and rates of prolonged postoperative opioid usage between patients undergoing total knee arthroplasty (TKA) after previous GNRFA and those undergoing TKA alone.

Methods:
Patients who underwent primary TKA after prior GNRFA (GNRFA-TKA) of the ipsilateral knee were identified in a national all-payer claims database from 2010 to 2019. Univariate and multivariable analyses were conducted comparing those with prior GNRFA and those without. Outcomes of interest included prolonged postoperative opioid usage, 2-year revision rates, and 90-day medical complications. Statistical analysis was conducted using R software provided by the PearlDiver Database.

Results:
In total, 675 patients in the GNRFA-TKA cohort were compared with a control cohort of 255,351 patients. Genicular nerve radiofrequency ablation-total knee arthroplasty patientshad lower odds of prolonged opioid use postoperatively (OR: 0.478; 95%: 0.409 to 0.559; P < 0.001). No notable difference was observed in the 2-year surgical outcomes between cohorts. Patients in the GNRFA-TKA cohort had lower odds of requiring a blood transfusion and having postoperative anemia, all arrhythmias, and urinary infections compared with primary TKA control patients.

Conclusion:
Preoperative GNRFA leads to a lower rate of prolonged postoperative opioid use in patients undergoing TKA, without an increased risk of complications. Future prospective studies are needed to validate the findings of this database study.
Seleção de defasagens em testes de raiz unitária: uma revisão de literatura
Authors: Silveira Anderson Garcia , Mattos Viviane Leite Dias de , Nakamura Luiz Ricardo , Amaral Mariane Coelho , Konrath Andrea Cristina 
Published: August 2022

Dentre as maneiras mais usuais de modelar e realizar previsões de demanda através de séries temporais, como, por exemplo a série de demanda por eletricidade, está a análise econométrica. Neste tipo de análise, a presença de raiz unitária pode fazer com que as previsões se tornem imprecisas. Assim, é fundamental identificar a presença de raiz unitária nas séries a serem modeladas. Para isso, podem ser aplicados os testes de raiz unitária, como por exemplo o teste ADF. Uma das etapas de grande importância na aplicação deste teste é a seleção de defasagens a serem utilizadas. Este trabalho apresenta de maneira qualitativa e quantitativa que a pesquisa por este tema se encontra em fase de expansão e que não existe um consenso no que tange à definição do número de defasagens a serem aplicadas no teste. Assim, fica evidente que este é um assunto em que cabe aprofundamento de pesquisa.
Analisis Kebocaran Gas SF6 Terhadap Kecepatan Busur Api dan Tegangan Tembus pada PMT di GISTET Saguling
Authors: Winanti Naftalin , Taryana Een , Sa’adah Gina Nur 
Published: August 2022

Gas Insulated Switchgear Extra High Voltage (GISTET) is a power system component that has a function as a distribution center (transmission) that connects the extra high voltage transmission system through distribution channels or substations.

Based on the installation of GISTET equipment, relying on hexafluoride gas (SF_6) as an insulating medium on the equpment. Equipment at GISTET is not always in good condition, GISTET also often experiences problems. One of the distrubances that GISTET often experiences is the leakage of SF6 gas at the PMT (circuit breaker). This requires a treatment called a GISTET overhaul. So in this paper the author will analyze the SSF_6 gas leak as insulation on the PMT (circuir breaker) at GISTET Saguling.

According to the results of the calculations in this final project, the gas pressure of SF_6 and the breakdown voltage of PMT are interrelated. At the pressure when the gas leak occurs is at a value below 5kgf/cm2it is able to with stand the voltage. Penetrating with a high value so it is very effective to reduce arc fire. In addition, the SF_6 gas pressure is also related to the arc speed because the lower the pressure value at the time of gas leakage, the arc speed decreases, so the arc will be slow to muffle.
Gambaran Pengobatan pada Pasien Dewasa ISPA di Puskesmas Sangia Wambulu Kabupaten Buton Tengah Tahun 2020
Authors: Teheni Muhammad Tasjiddin , Ilham Sitti Alfyanita , Darmawati  
Published: August 2022

Penelitian bertujuan mengetahui gambaran pengobatan pada pasien dewasa Infeksi Saluran Pernafasan Akut berdasarkan karakteristik pasien dan obat di Puskesmas Sangia Wambulu Kabupaten Buton Tengah Tahun 2020. Penelitian menggunakan metode deskriptif retrospektif dengan jumlah sampel sebanyak 67 sampel. Hasil penelitian ini menunjukan bahwa pasien dewasa Infeksi Saluran Pernafasan Akut berdasarkan jenis kelamin perempuan lebih besar, umur berkisar 41-50 tahun, berat badan pasien 51-60 kg, diagnosa ISPA ringan. Obat dan lama pemberian yang digunakan paracetamol 4 hari, ibuprofen 4 hari, loratadin 5 hari, cetirizine 3-4 hari, CTM 4-5 hari, vitamin C 4-5 hari, vitamin becom 3 ,4 hari, dexamethasone 4 hari, prednisolone 4 hari, metihylprednisolone 4-7 hari, bacefort 5 hari, natrium diklofenak 5 hari, antasida 4 hari dan guaifenesin 4-5 hari
Analisis Nilai Wajar Saham Pada PT Wijaya Karya Beton Tbk Dengan Menggunakan Metode Gordon Growth Model
Authors: Nurul Azmi  , Arthari Tiara Namira  
Published: August 2022

Penelitian ini bertujuan untuk menentukan nilai harga wajar saham pada PT. Wijaya Karya Beton Tbk. Pada tahun 2021 dengan menggunakan metode Gordon growth model sehingga dapat membandingkan dengan harga pasar saham beredar tersebut. Dalam menentukan harga wajar saham dan pengambilan keputusan investasi, penulis menggunakan metode Gordon grow thodel dengan unsur pokok yaitu required rate of return, expected growth rate, dan value of stock serta membandingkan harga wajar dengan harga pasar saham tersebut. Berdasarkan hasil perhitungan dan analisis yang telah dilakukan pada PT. Wijaya Karya Beton Tbk. dapat diketahui bahwa harga saham berada pada harga Rp 246 per lembar saham sedangkan berdasarkan hasil perhitungan yang didapat yaitu harga wajar sebesar Rp 22 per lembar saham. Maka dapat disimpulkan bahwa harga saham PT. Wijaya Karya Beton Tbk. bersifat overvalued.
Tomatoes By-products Extracts Mediated Green Synthesis of Silver Nanoparticles and Their Application as Antimicrobial Agent
Authors: Balčiūnaitienė Aistė , Viškelis Jonas , Urbonavičienė Dalia , Viškelis Pranas 
Published: August 2022

Silver nanoparticles (AgNPs) biosynthesized using by-products of tomatoes extracts as reducing and capping agents show multiple possibilities for solving various biological problems. The aim of this study was to expand the boundaries on AgNPs using novel low toxicity and production cost phytochemical method for the biosynthesis of nanoparticles from tomatoes aqueous extracts. Biosynthesized AgNPs were characterized by various methods (SEM, EDS). Determined antioxidative and antimicrobial activity of plant extracts was compared with the activity of the AgNPs. TEM results show mainly spherical-shaped AgNPs, size distribution of which depends on the plant leaf extract type; the smaller AgNPs were obtained with tomatoes extract (6–45 nm AgNPs). Besides, AgNPs show strong antimicrobial activity against broad spectrum of Gram-negative and Gram-positive bacteria strains and fungi.
Isolation of Contaminating Bacteria from Aqueous Solution of Contact Eye Lenses
Authors: Ali Abdelhakam H. , M. Abdulwahab A. Fadil , Zroog Susan Ali , Gorish Babbiker Mohammed Taher 
Published: August 2022

Background: Contact lenses have been widely used as an alternative to spectacles both in developed and non-developing countries. However, under certain circumstances, adverse responses can occur during contact lens wear and several microorganisms including bacteria, fungi, and free living amoebae—can cause several eye infections. This study was aimed to isolate contaminating bacteria from eye lenses solution.
Methods: The samples were collected from solution bottles of eye lenses with the help of sterile cotton tipped swabs that were pre- moistened with sterile normal saline, then sample directly cultured on solid media. All samples were inoculated on to blood agar, MacConkey’s agar were incubated at 37oC for 24-48 h, Cultures were considered negative if no growth was detected within 48 hours of incubation. Bacterial culture obtained was identified using Gram’s staining, on the basis of culture diagnosis by growing on media and performing biochemical test.
Results: A total of 150 samples from aqueous solution of contact eye lenses were used to isolate bacteria from it. Out of these samples 84 bacteria were isolated from aqueous solution while 66 were without growth. The most frequent isolated bacteria were P.aeurogenosa 39(46%) followed by S. epidermidis 27 (32%) then S. aureus 12 (14%) and E. coli 6(7%) respectively which is significant result (P-Value of 0.005).
Conclusion: The study revealed that contact lenses solution under investigation contains different types of bacteria and pseudomonas is more frequent bacteria. Furthermore the contact lenses with multiple use and users which not have difference types of bacteria growth.
Endoscopically Assisted Repair of Nasal Septal Perforation Using Platelet Rich Plasma
Authors: Sharaf Mohammed Ibrahim , Tamom Mohamed Osama , Al-Bermawy Osama Amin , Asker Mohammed Hamid 
Published: August 2022

Background: Nasal septal perforations (NSPs) are nasal septum defects as a result of necrosis to the cartilage or bony tissues in addition to their mucous membrane on both surfaces. the current work aimed to estimate endoscopically assisted repair of medium-sized nasal septal perforation using inferiorly based rotational flap together with Platelet rich plasma (PRP).
Methods: It was a randomized controlled double-blind study recruited on 40 cases with anterior septal perforation for endoscopic repair. Patients randomly were allocated into two equal groups: group A were cases with anterior septal perforation for endoscopic repair using inferior based mucosal rotational and septal flaps only and group B were patients subjected to inferior based mucosal rotational and septal flaps together with PRP. All participants were exposed to thorough history taking, laboratory, clinical examination, and radiological investigation.
Results: Number of patients who had complete or partial closure of septal perforation, was insignificantly different between both groups. Number of patients who had decrease in size of perforation, same size perforation, residual symptoms, and who were asymptomatic was insignificant difference between both groups. Times to disappearance of residual epistaxis and residual crustation were significantly earlier in group B in comparison with group A (P = 0.001 and 0.011 respectively).
Conclusions: Overall, PRP is a promising material for nasal septal perforation. Times to disappearance of residual epistaxis and residual crustation were remarkably earlier in group B in comparison with group A.
Tolerability of COVID-19 Infection and Messenger RNA Vaccination Among Patients With a History of Kawasaki Disease
Authors: Beckley Mikayla , Olson Aaron K. , Portman Michael A. 
Published: August 2022

ImportanceKawasaki disease (KD) symptoms significantly overlap with multisystem inflammatory syndrome in children due to COVID-19. Patients with KD may be at risk for adverse outcomes from exposure to SARS-CoV-2 infection or vaccination.ObjectiveTo describe the outcomes of patients with KD to SARS-CoV-2 infection or vaccination.Design, Setting, and ParticipantsThis case series evaluated 2 cohorts using an existing KD database and reviewed individual electronic medical records for the period spanning January 1, 2020, through January 31, 2022, via electronic medical records that include Washington state immunization records. Vaccine cohort inclusion criteria consisted of being 21 years or younger at immunization and receiving 1 or more BNT162b2 (Pfizer-BioNTech) or messenger RNA (mRNA)–1273 (Moderna) vaccine doses. The COVID-19 cohort included patients 21 years or younger with positive polymerase chain reaction or nuclear capsid IgG findings for SARS-CoV-2. Participants included 826 patients from a preexisting KD database. One hundred fifty-three patients received at least 1 BNT162b2 or mRNA-1273 vaccine dose and were included in the mRNA vaccine cohort. Thirty-seven patients had positive test results for SARS-CoV-2 and were included in the COVID-19 cohort.ExposuresSARS-CoV-2 vaccination and/or infection.Main Outcomes and MeasuresAdverse events after mRNA vaccination and/or COVID-19, including clinician visits, emergency department encounters, or hospitalizations.ResultsAmong the 153 patients included in the mRNA vaccination cohort (mean [SD] age, 13.0 [4.3] years; 94 male [61.4%]), the BNT162b2 vaccine was provided for 143 (93.5%), and the remaining 10 (6.5%) received mRNA-1273 or a combination of both. Among patients in the vaccine cohort, 129 (84.3%) were fully vaccinated or received a third-dose booster. No clinically severe adverse events occurred, and there were no reports of vaccine-related hospitalizations or outpatient visits. The COVID-19 cohort included 37 patients (mean [SD] age, 11.0 [5.5] years; 22 male [59.5%]). No patients required hospitalization due to COVID-19. The most common symptoms included low-grade fever, fatigue, cough, and myalgia with resolution within a few days. Two patients, aged 9 and 19 years, had extended cough and fatigue for 3 to 4 weeks. One patient developed COVID-19 within 6 weeks of receiving intravenous immunoglobulin for KD.Conclusions and RelevanceThese findings suggest that the mRNA vaccines may be safe and COVID-19 may not be severe for patients with a history of KD.
On the Stability of Non‐fullerene Acceptors and Their Corresponding Organic Solar Cells: Influence of Side Chains
Authors: Zhou Bojun , Wang Liang , Liu Yang , Guo Chuanhang , Li Donghui , Cai Jinlong , Fu Yiwei , Chen Chen , Liu Dan , Zhou Yinhua , Li Wei , Wang Tao 
Published: August 2022

AbstractSide chain engineering is a widely explored strategy in the molecular design for non‐fullerene acceptors (NFAs). Although the relationship between side chain structures and optoelectronic properties of NFAs is well clarified, the effect of side chain structures on the stability of NFAs and their corresponding organic solar cells (OSCs) is rarely reported. Herein, a series of Y‐family NFAs with varying side‐chains are studied to investigate their degradation upon multiple stresses including water, oxygen from ambient, chemical environment from ZnO electron transport layer, temperature, and ultraviolet light. The results show that all of these Y‐family NFAs are highly stable against water and oxygen in ambient dark condition, while their photochemical and thermal stabilities decrease with the increasing side chain length. NFAs with shorter side chains are not only more resistant to photo‐oxidation and photocatalytic reactions, but also can hamper the formation of large phase‐separated NFA domains upon storage in both glovebox and ambient conditions. As such, the PM6:NFA OSC with short side‐chain NFA also exhibits superior operational stability, associating with a higher T80 lifetime. This study demonstrates that the side chains must be considered to obtain stable OSCs.
The Unprecedented Highest‐Layer‐Number Ferroelectric Semiconductor of 2D Homologous Single‐Phase Perovskites Tailored by Regulating Thickness of Inorganic Frameworks
Authors: Guo Wuqian , Xu Haojie , Ma Yu , Liu Yi , Wang Beibei , Tang Liwei , Hua Lina , Luo Junhua , Sun Zhihua 
Published: August 2022

AbstractFerroelectric semiconductors represent an exciting branch of new‐generation optoelectronic devices. However, regarding severe polarization deterioration caused by leakage current, it is challenging to couple ferroelectricity and semiconductive properties in a single‐phase material. The first quadrilayered ferroelectric semiconductor of 2D homologous perovskites, IA2Cs3Pb4Br13 (IA = isoamylammonium), showing distinctive ferroelectric characteristics of symmetry breaking at 351 K and large polarization of 4.2 µC cm‐2 is presented here. The design strategy of increasing layer‐number endows higher Curie temperature and superior semiconductor merits than other lower‐layered members (IA2Csn‐1PbnBr3n+1, n = 1–3). Bulk photovoltaic effects in IA2Cs3Pb4Br13 result in a notable dichroism up to ≈1.2 for self‐driven polarized‐light detection. This unprecedented study opens an avenue toward the targeted performance optimization of electric‐ordered functional materials.