bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiences of intimate continence care and the impact on the family dyad relationship for people living at home with dementia and their co-resident family members
Authors: Cole Laura , Drennan Vari M , Manthorpe Jill , Hatzidimitriadou Eleni , Iliffe Steve 
Published: April 2022

Objectives The experience of providing/receiving intimate continence care between family members can be difficult and emotive. Often, for people living with dementia this seems an area of care overlooked by professionals. This study investigated the experiences of intimate continence care for people living with dementia and their family member (the family dyad), and whether they viewed this as impacting on their relationship. Method Face-to-face interviews were conducted at 6 monthly intervals over a 12-month period with 13 carers (all family members) and one person living with dementia (13 family dyads) in England. Interviews were recorded and transcribed. Analysis of the data was achieved using a descriptive phenomenological method. Findings Carers’ attitudes towards providing intimate continence care revealed a task-focused approach for some but feelings of disgust and distress for others. Four participants (including the participant living with dementia) reported that intimate continence care had strengthened their dyad relationship. However, some carers perceived the care and support received from health and social care practitioners to be insufficient, which placed extra stress on them and adversely affected their family dyad relationship. Conclusion Implications of the study suggest that integrated and effective continence care and support for people living with dementia and their carers could (1) maintain the quality of the family dyad relationship, (2) help keep the person living at home, delaying an unwanted move to a care home and (3) consequently improve overall quality of life for individuals in the family dyad. Assuring integrated and effective continence care should be a priority for service funders and quality assurance regulators.
Failure mechanisms of kenaf/glass sandwich laminates subjected to low velocity impact loading
Authors: Ahmad Nadzri Seri Nur Zumaimi , Md Shah Ain Umaira , Sultan Mohamed Thariq Hameed , Safri Syafiqah Nur Azrie , Shahar Farah Syazwani , Basri Adi Azriff 
Published: April 2022

Stacking sequences of composite laminates have significant effects not only on the properties of composites but also on the types of damage occurred on the composites structure. The current study investigated the low velocity impact properties and the damage progression of kenaf core sandwich laminates in different layering sequence of fibre laminates. There were three different sequences of kenaf (K) and glass (G) fibre reinforced unsaturated polyester composites, that is, G/K/G hybrid, G/K/K hybrid and K/K/K composites, which were fabricated using hand lay-up method. The layer of gelcoat provided a protective layer and finishing to the composite. The composites experienced the low velocity impact at three different energy levels which were 5 J, 10 J and 15 J. Through the research, a diamond shape matrix cracking was exhibited on the gelcoat surface. The main failure mode that occurred on the specimen during the low velocity impact was matrix cracking, fibre breakage, delamination and fibre pulled-out. From the results, G/K/G hybrid resisted the highest impact energy which is up to 10 J and G/K/K hybrid resisted up to 5 J. Meanwhile K/K/K composite failed to resist any of designated energy. Therefore, it can be suggested that G/K/G hybrid composites had shown good performance in low velocity impact properties to be used as the bus bumper material.
Effect of layering sequence and ambient temperature on thermal insulation of multilayer high bulk nonwoven under extreme cold temperatures
Authors: Dupade Vikrant , Kumari Ranjna , Premachandran Balachandran , Rengasamy Raju Seenivasan , Talukdar Prabal 
Published: April 2022

In extreme cold weather clothing ensemble, multiple layers of high bulk nonwovens are used to provide thermal insulation to the wearer. In this work, the effect of layering sequence in multi-layered high bulk thermal bonded nonwoven assembly on its thermal resistance is evaluated experimentally under sub-zero temperatures. Two multi-layered nonwovens, one made up of 1.4 denier solid (1.4 D S), 6 denier hollow (6 D H) and 15 denier hollow (15 D H) and the second made up of 3 denier hollow (3 D H), 6 denier hollow (6 D H) and 15 denier hollow (15 D H) polyester fibres were studied. The experiments were performed in a climatic chamber in the temperature range of 310 K to 210 K. Numerical simulations were carried out assuming heat transfer through the nonwovens as one-dimensional coupled conduction-radiation. The numerical methodology was developed using theoretical relations available in the literature to estimate the steady-state temperature profiles through the nonwoven layers and were validated using experimental data. The concurrence of experimental and numerical temperature profiles justifies the numerical methodology adopted in this work. Thermal resistance provided by the high bulk nonwoven increases with a decrease in ambient temperature. It is found that the thermal conductivity of nonwoven layers decreases from inner-to outer layers at a given ambient temperature. The heat flux through nonwoven layers, overall thermal conductivity and the thermal resistance of multi-layer nonwoven are independent of layering sequence if the convective heat transfer is extremely low.
Gross Tumor Volume Segmentation for Stage III NSCLC Radiotherapy Using 3D ResSE-Unet
Authors: Yu Xinhao , Jin Fu , Luo HuanLi , Lei Qianqian , Wu Yongzhong 
Published: April 2022

Introduction: Radiotherapy is one of the most effective ways to treat lung cancer. Accurately delineating the gross target volume is a key step in the radiotherapy process. In current clinical practice, the target area is still delineated manually by radiologists, which is time-consuming and laborious. However, these problems can be better solved by deep learning-assisted automatic segmentation methods. Methods: In this paper, a 3D CNN model named 3D ResSE-Unet is proposed for gross tumor volume segmentation for stage III NSCLC radiotherapy. This model is based on 3D Unet and combines residual connection and channel attention mechanisms. Three-dimensional convolution operation and encoding-decoding structure are used to mine three-dimensional spatial information of tumors from computed tomography data. Inspired by ResNet and SE-Net, residual connection and channel attention mechanisms are used to improve segmentation performance. A total of 214 patients with stage III NSCLC were collected selectively and 148 cases were randomly selected as the training set, 30 cases as the validation set, and 36 cases as the testing set. The segmentation performance of models was evaluated by the testing set. In addition, the segmentation results of different depths of 3D Unet were analyzed. And the performance of 3D ResSE-Unet was compared with 3D Unet, 3D Res-Unet, and 3D SE-Unet. Results: Compared with other depths, 3D Unet with four downsampling depths is more suitable for our work. Compared with 3D Unet, 3D Res-Unet, and 3D SE-Unet, 3D ResSE-Unet can obtain superior results. Its dice similarity coefficient, 95th-percentile of Hausdorff distance, and average surface distance can reach 0.7367, 21.39mm, 4.962mm, respectively. And the average time cost of 3D ResSE-Unet to segment a patient is only about 10s. Conclusion: The method proposed in this study provides a new tool for GTV auto-segmentation and may be useful for lung cancer radiotherapy.
A single dedicated vaccination visit improves vaccination coverage of patients with inflammatory bowel disease
Authors: Le Cosquer Guillaume , Grangeon Lionel , Rivière Pauline , Berger Arthur , Zerbib Frank , Laharie David , Poullenot Florian 
Published: April 2022

Introduction: Patients treated with biologics for inflammatory bowel disease (IBD) have an increased risk of severe infections. Real-life vaccination coverage in this population remains low despite international vaccination guidelines. The aim of this study was to evaluate the impact of a dedicated vaccination visit on vaccination coverage. Methods: A dedicated vaccination visit was offered to all patients admitted for an infusion of a biologic in a tertiary IBD center during a 4-week period. At baseline, vaccination status was collected. Patients received specific information on recommended vaccinations. Perceived utility of both vaccination and the dedicated visit were assessed by visual analogue scale (VAS). Vaccination coverage was reassessed 6 months later by phone call. Results: Among the 207 patients analyzed (1 patient declined), rates of vaccination at baseline and 6 months later against diphtheria were 52.7% and 68.6% ( p < 0.001), tetanus 55.1% and 70% ( p < 0.001), poliomyelitis 51.7% and 68.6% ( p < 0.001), pertussis 33.3% and 51.2% ( p < 0.001), hepatitis B virus (HBV) 61.4% and 66.7% ( p < 0.01), pneumococcus 15.5% and 42.0% ( p < 0.001), influenza 29.5% and 36.2% ( p < 0.01), and meningococcus C 11.6% and 13.0% ( p = 0.083), respectively. A quarter of the patients declined at least one recommended vaccination after the visit. The main reason for this refusal was distrust toward one or more vaccines. Conclusion: A single visit dedicated to vaccination significantly increases rates of vaccination in patients with IBD treated with biologics.
Promoción de salud más allá de los estilos de vida saludables: propuestas de actuación en una universidad chilena
Authors: Pérez-Wilson Patricia , Marcos-Marcos Jorge , Ruiz-Cantero María Teresa , Carrasco-Portiño Mercedes , Alvarez-Dardet Carlos 
Published: April 2022

Resumen: Las intervenciones centradas en cambios de conducta, sumadas a la escasa evidencia de mapeo y dinamización de activos en Universidades Promotoras de Salud (UPS), hacen necesario potenciar enfoques integrales y sistémicos que contribuyan al bienestar y empoderamiento de sus integrantes. El objetivo de este artículo es explorar propuestas de acción que contribuyan a fortalecer activos en una comunidad universitaria chilena. Se desarrolló un estudio cualitativo con 72 hombres/77 mujeres (estudiantes, trabajadores, jubilados y exestudiantes). Se realizaron 48 entrevistas individuales y 14 grupos focales. Se efectuó un análisis de contenido utilizando el software QRS NVivo 12. Las propuestas identificadas se agruparon en: desarrollo de la participación e inclusión, promoción de la salud mental, mantenimiento y mejora de áreas verdes e infraestructura, y fortalecimiento del acceso a actividades deportivas, culturales y de extensión universitaria. Las mujeres valoraron la difusión de activos comunitarios y el cuidado de las personas y el entorno. Y los hombres, el fortalecimiento del capital social, la docencia y la transferencia de conocimiento. Las propuestas de acción tienen una orientación colectiva que favorece el vínculo de las personas con su entorno y el desarrollo del sentido de comunidad. Desde una perspectiva de género, se observa reproducción de roles y estereotipos arraigados en el sistema patriarcal. Esto constituye un desafío para potenciar las UPS en tanto política pública, considerando los principios de participación, justicia social y equidad.
A Pre-Clinical Animal Study for Zonal Articular Cartilage Regeneration Using Stratified Implantation of Microcarrier Expanded Zonal Chondrocytes
Authors: Tee Ching Ann , Yang Zheng , Wu Yingnan , Ren Xiafei , Baranski Maciej , Lin Daryl Jimian , Hassan Afizah , Han Jongyoon , Lee Eng Hin 
Published: April 2022

Objective The zonal properties of articular cartilage critically contribute to the mechanical support and lubrication of the tissue. Current treatments for articular cartilage have yet to regenerate this zonal architecture, thus compromising the functional efficacy of the repaired tissue and leading to tissue degeneration in the long term. In this study, the efficacy of zonal cartilage regeneration through bilayered implantation of expanded autologous zonal chondrocytes was investigated in a porcine chondral defect model. Design Autologous chondrocytes extracted from articular cartilage in the non-weight bearing trochlea region of the knee were subjected to an expansion-sorting strategy, integrating dynamic microcarrier (dMC) culture, and spiral microchannel size-based zonal chondrocyte separation. Zonal chondrocytes were then implanted as bilayered fibrin hydrogel construct in a porcine knee chondral defect model. Repair efficacy was compared with implantation with cell-free fibrin hydrogel and full thickness (FT) cartilage-derived heterogenous chondrocytes. Cartilage repair was evaluated 6 months after implantation. Results Sufficient numbers of zonal chondrocytes for implantation were generated from the non-weight bearing cartilage. Six-month repair outcomes showed that bilayered implantation of dMC-expanded zonal chondrocytes resulted in substantial recapitulation of zonal architecture, including chondrocyte arrangement, specific Proteoglycan 4 distribution, and collagen alignment, that was accompanied by healthier underlying subchondral bone. Conclusion These results demonstrate that with appropriate expansion and isolation of zonal chondrocytes, the strategy of stratified zonal chondrocyte implantation represents a significant advancement to Autologous Chondrocyte Implantation-based cartilage regeneration, with the potential to improve the long-term integrity of the regenerated tissues.
Male involvement in family planning use and associated factors among currently married men in rural Eastern Ethiopia
Authors: Mulatu Teshale , Sintayehu Yitagesu , Dessie Yadeta , Dheresa Merga 
Published: April 2022

Introduction/Objectives: Male involvement in family planning refers to all organizational actions focused on men as a distinct group to increase the acceptability and uptake of family planning among either sex. Despite the growing evidence of male involvement in increasing family planning uptake among couples, a little success has been achieved in Ethiopia, especially in rural areas. Hence, this study aimed to assess male involvement in family planning and its associated factors among currently married men in selected rural areas of Eastern Ethiopia. Methods: A community-based cross-sectional survey was conducted among 577 randomly selected currently married men, using a simple random sampling method in randomly selected rural districts of Eastern Ethiopia. Data were collected using a pretested interviewer-administered questionnaire. The collected data were entered into a computer using Epi-Data Version 3.1. The analysis was performed using the Statistical Package for the social sciences software version 21. Logistic regression analysis was used to analyze the association between the dependent and independent variables. Finally, adjusted odds ratio with 95% confidence intervals at P-value < 0.05 was considered to be significantly associated with the outcome variable. Results: Out of 577, a total of, 555 married men were included in the study, resulting in a response rate of 96.2%. The magnitude of male involvement in family planning use was 59.3% (95% confidence interval: 47.1, 68. 2). Ever use of family planning by a spouse (adjusted odds ratio: 2.37; 95% confidence interval: 1.59, 3.52), ever discussion of spouse on sexual and reproductive health/family planning issues (adjusted odds ratio: 2.05; 95% confidence interval: 1.40, 3.02), and the husband’s approval of family planning (adjusted odds ratio: 2.45; 95% confidence interval: 1.34, 4.96) were significantly associated with higher odds of male involvement in family planning use than their counterparts. Conclusion: The number of men involved in the family planning was low. Ever use of family planning methods by a spouse, ever discussion of spouse on sexual and reproductive health/family planning issues, and husband approval on family planning use were found to be important predictors of male involvement in family planning use. To improve modern family planning uptake among men and women, it is imperative to include men in family planning programs, such as family planning messaging, sensitizations, and services.
Sleep Disturbance in the Context of HIV: A Concept Analysis
Authors: Pujasari Hening , Chung Min-Huey 
Published: April 2022

Due to the differing definitions of the concept of sleep disturbance among people living with human immunodeficiency virus (HIV), reviewers in this area have not reached any firm conclusions. The study aimed to clarify and provide a stronger foundation for the definition of sleep disturbance in the context of HIV to enhance the concept’s development. Following Beth Rodgers’ concept analysis guidelines, two leading databases were searched, and 73 articles were used for this concept analysis. The attributes, surrogate terms, antecedents, and consequences of sleep disturbance have been identified using thematic analysis. In this analysis, two main attributes of sleep disturbance in the context of HIV were identified: a) subjective measures, including reduced total sleep time, difficulty falling asleep, nighttime and early morning awakenings, feeling sleepy and poorly rested after a night’s sleep, frequent arousals, and irritability, and b) objective measures, including changes in sleep architecture and sleep continuity. Five antecedents of sleep disturbance in the context of HIV were identified. Meanwhile, the consequences of sleep disturbance in HIV are listed based on the frequency the points occur within the reviewed articles. The list is as follows: fatigue and pain; reduced neurocognitive functions; reduced health outcome and quality of life; poor anti-retroviral (ARV) therapy adherence; daytime sleepiness; depression, anxiety, and maladaptive coping; increased disease progression and cardiovascular mortality; and social phobia, living arrangement and sexual dysfunction. An improved understanding of sleep disturbance in the context of HIV will be beneficial in directing analysts to develop research plans. At the same time, the knowledge gaps identified in the analysis provided a solid basis for further study intending to fill in these gaps.
Exploring the Perspective of Diabetes, Diabetes Self-Management, and Quality of Life Among Older Adults With Type 2 Diabetes: A Qualitative Study Before and During the COVID-19 Pandemic
Authors: Tan Jamaica Pei Ying , Seah Siang Joo , Harding Susana Concordo , Pay Jin Yu , Wang Jing , Aw Su , Lam Jocelin , Boon Tar Lim Raymond 
Published: April 2022

Purpose The purpose of the study was to explore the perspective and impact of diabetes, diabetes self-management, and quality of life (QoL) among older adults with Type 2 diabetes (T2DM) before and during the COVID-19 pandemic to better inform T2DM self-management interventions. Methods A qualitative descriptive approach with focus group discussions (n = 5 sessions with 5-6 older adults per session) and in-depth interviews (n = 15) was conducted with community-dwelling older adults with T2DM. Results Five themes emerged. The definition of diabetes carries negative connotations, QoL is defined in terms of biopsychosocial health, diabetes self-management refers to the ability to adhere to medical advice and lifestyle changes, the QoL of older adults is differentially affected by COVID-19 measures, and important aspects of diabetes self-management activities are impacted by COVID-19 measures. Conclusions Understanding older adults’ perspectives on diabetes, diabetes self-management, and QoL provided insights into the facilitators and barriers to diabetes self-management practices before and during the COVID-19 pandemic. Findings inform the need for greater bottom-up initiatives and the need for a multipronged approach that considers the intra- and interpersonal and current policy factors to encourage diabetes self-management behaviors, especially during the COVID-19 era.
Universal lung epithelium DNA methylation markers for detection of lung damage in liquid biopsies
Authors: Magenheim Judith , Rokach Ariel , Peretz Ayelet , Loyfer Netanel , Cann Gordon , Amini Hamed , Moradi Patriss , Nagaraju Sudharani , Sameer Wafa , Cohen Assaf , Fogel Ophir , Kuint Rottem , Abutbul Avraham , Abu Rmeileh Aiman , Karameh Mutaz , Cohen Goichman Polina , Wald Ori , Korach Amit , Neiman Daniel , Fox-Fisher Ilana , Moss Joshua , Cohen Daniel , Piyanzin Sheina , Ben Ami Roni , Quteineh Ahmad , Golomb Eliahu , Shemer Ruth , Glaser Benjamin , Kaplan Tommy , Fridlender Zvi G. , Dor Yuval 
Published: April 2022

BackgroundCirculating biomarkers for lung damage are lacking. Lung epithelium-specific DNA methylation patterns can potentially report the presence of lung-derived cell-free DNA (cfDNA) in blood, as an indication of lung cell death.MethodsWe sorted human lung alveolar and bronchial epithelial cells from surgical specimens, and obtained their methylomes using whole-genome bisulfite sequencing. We developed a PCR sequencing assay determining the methylation status of 17 loci with lung-specific methylation patterns, and used it to assess lung-derived cfDNA in the plasma of healthy volunteers and patients with lung disease.ResultsLoci that are uniquely unmethylated in alveolar or bronchial epithelial cells are enriched for enhancers controlling lung-specific genes. Methylation markers extracted from these methylomes revealed that normal lung cell turnover probably releases cfDNA into the air spaces, rather than to blood. People with advanced lung cancer show a massive elevation of lung cfDNA concentration in blood. Among individuals undergoing bronchoscopy, lung-derived cfDNA is observed in the plasma of those later diagnosed with lung cancer, and to a lesser extent in those diagnosed with other lung diseases. Lung cfDNA is also elevated in patients with acute exacerbation of COPD compared with patients with stable disease, and is associated with future exacerbation and mortality in these patients.ConclusionsUniversal cfDNA methylation markers of normal lung epithelium allow for mutation-independent, sensitive and specific detection of lung-derived cfDNA, reporting on ongoing lung injury. Such markers can find broad utility in the study of normal and pathologic human lung dynamics.