bluuebunny/crossref_metadata_2025_split huggingface dataset:
High energy, double pass helium plasma dermal resurfacing: A prospective, multicenter, single‐arm clinical study
Authors: Holcomb J. David , Doolabh Vaishali , Lin Michael , Zimmerman Edward 
Published: February 2022

AbstractBackgroundA previous multi‐center clinical study of low energy (20% power), single‐pass helium plasma dermal resurfacing (HPDR) showed positive results but did not fully reveal the true potential of this novel technology. A second multi‐center clinical study, reported herein, was therefore undertaken to evaluate efficacy and safety of high energy (40%), double pass HPDR for treatment of facial rhytids (ClinicalTrials.gov Identifier: NCT04185909).MethodsFifty‐five eligible subjects seeking improvement in facial rhytids were enrolled for study at one of four investigational sites. All subjects underwent full‐face HPDR treatment. The forehead, nose, cheeks, and peri‐oral treatment zones were treated at 40% power with two passes whereas the peri‐orbital and jawline/mandibular zones were treated at 20% power (up to 40% for jawline/mandibular zone) and one or two passes. Photographic images of the face were captured using the VISIA‐CR system. Three‐month posttreatment Fitzpatrick Wrinkle and Elastosis Scale (FWS) scores were compared to baseline scores as determined by blinded independent photographic reviewers (IPRs) and study investigators.ResultsBlinded IPRs and study investigators observed a ≥1‐point FWS improvement in 100% of subjects with mean change in IPR FWS from baseline to the 90‐day visit of −3.6 (±1.2). 96.4% of subjects indicated “improvement” in appearance at the 90‐day visit utilizing the modified Global Aesthetic Improvement Scale. Evaluation of VISIA‐CR data revealed statistically significant improvements in wrinkles, brown spots, and pore counts. Overall, 269 Adverse Events in 55 subjects were reported; most were mild‐moderate in severity (99.3%), anticipated (86.2%), and of relatively short duration with most having resolved within 30 days (60.6%) of treatment.ConclusionTreatment of facial rhytids with high energy, double pass HPDR as detailed herein enables a marked improvement in FWS that parallels or surpasses competing technologies. VISIA‐CR analysis demonstrates additional improvements in skin quality with statistically significant quantitative improvements in brown spots and enlarged pores as well as wrinkles. Effective rhytid effacement combines with high subject satisfaction and few unanticipated adverse events for a reasonable benefit‐risk ratio.
Quantum B‐modules
Authors: Zhang Xia , Rump Wolfgang 
Published: February 2022

AbstractQuantum B‐algebras are partially ordered algebras characterizing the residuated structure of a quantale. Examples arise in algebraic logic, non‐commutative arithmetic, and quantum theory. A quantum B‐algebra with trivial partial order is equivalent to a group. The paper introduces a corresponding analogue of quantale modules. It is proved that every quantum B‐module admits an injective envelope which is a quantale module. The injective envelope is constructed explicitly as a completion, a multi‐poset version of the completion of Dedekind and MacNeille.
Genetic testing users in Italy and Germany: Health orientation, health‐related habits, and psychological profile
Authors: Ongaro Giulia , Brivio Eleonora , Cincidda Clizia , Oliveri Serena , Spinella Francesca , Steinberger Daniela , Cutica Ilaria , Gorini Alessandra , Pravettoni Gabriella 
Published: February 2022

AbstractBackgroundRapid advances in genomic knowledge and widespread access to the web contributed to the development of genetic services by private companies or medical laboratories. In the European landscape, though, there is not a single coherent regulatory approach to genetic testing (GT). The study aimed to investigate differences and similarities between two populations of GT users, Italians and Germans, in terms of health‐related behaviors, psychological characteristics, and attitudes toward genetic information.MethodsNinety‐nine Italian GT users from one private genetic company and 64 Germans GT users from one medical laboratory, completed an ad hoc self‐administered questionnaire.ResultsResults showed significant differences in health‐related behaviors (unhealthy eating behaviors, smoking behaviors, and frequency in medical check‐ups), with Germans reporting higher levels of unhealthy eating habits and smoking behaviors than Italians; Italian users also were more medically controlled. Furthermore, German participants were less willing to change their lifestyle following the GT results compared to Italian participants. Regarding psychological variables, German users felt more confident about their physical well‐being and they seemed more motivated than Italians to avoid becoming unhealthy. Finally, two samples differed in the way they accessed genetic testing (with the Italians guided predominately by a physician in contrast with the Germans who were recommended by friends) and managed genetic testing results (with Italian participants significantly more willing to share results with doctors than German participants, who preferred sharing with the family).ConclusionThe analysis of cultural and organizational differences could help in defining adequate guidelines for counseling, and provide inputs for regulators in different European contexts.
Thermomechanical performance of biodegradable poly (lactic acid)/carbonaceous hybrid nanocomposites: Comparative study
Authors: Charitos Ilias , Klonos Panagiotis A. , Kyritsis Apostolos , Koralli Panagiota , Kontos Athanassios G. , Kontou Evagelia 
Published: February 2022

AbstractIn the present research, a series of hybrid nanocomposites based on polylactic acid (PLA) matrix and mixtures of graphene oxide (GO) with carbon nanotubes (CNTs) or carbon nanofibers (CNFs), at various loadings, were prepared and experimentally studied. Several experimental techniques were employed to analyze the morphology and the thermomechanical performance of the materials, as well as the dielectric properties. The related experimental data support the conclusion that a synergistic effect is exhibited by the PLA/GO/CNT nanocomposites. This effect was verified by the higher mechanical enhancement, the higher crystallinity and the development of conductive paths into the bulk matrix.
High antibacterial activity of new eco‐friendly and biocompatible polyurethane nanocomposites based on Fe3O4/Ag and starch moieties
Authors: Kamali Farinaz , Faghihi Khalil , Mirhoseini Farid 
Published: February 2022

AbstractControl of microbial infections is one of the growing concerns in modern societies due to the increasing presence and risk of pathogenic bacterial spread. Therefore, there is a strong demand to design new antibacterial agents to overcome these problems. The aim of this study is the preparation of a new series of biocompatible starch‐based polyurethane (PU) nanocomposites with a unique combination of magnetic nanoparticles (MNPs) and silver nanoparticles (AgNPs). In order to perform the study, first, a new synthetic diisocyanate was synthesized by a three‐step reaction and grafted into bis(2‐hydroxyethyl terephthalate) (BHET) and starch as a covering agent of MNPs containing different amounts of AgNPs. Afterward, the diisocyanate containing two active isocyanate moieties was reacted with hydroxyl groups of BHET and starch to form stable urethane linkages. Subsequently, the antibacterial activity of the pure synthetic PU and the produced nanocomposites were investigated against Escherichia coli and Staphylococcus aureus as Gram‐negative and Gram‐positive microorganism models, respectively. The obtained results exhibited that the nanocomposites have a synergistic effect on the antibacterial activity, which decreased with increasing of the Ag content. Such results may be related to the AgNPs agglomeration in the nanocomposite.
Thermal Behaviour and Kinetic Parameters of Ternary Mg+SrO2+DNAN Pyrotechnic Compositions
Authors: Rosères Charles , Courty Léo , Gillard Philippe , Boulnois Christophe 
Published: February 2022

AbstractThermal analyses of raw components are necessary to understand the behavior of pyrotechnic compositions they are incorporated in. Ternary compositions containing strontium peroxide, magnesium, and 2,4‐dinitroanisole (DNAN) are studied thermally using TGA and DSC. Activation energies are given for the components using three different methods. Thermal behavior of strontium peroxide is focused on as little scientific literature exists about it: heat capacity is measured, and a thermal evolution model is given. Effects of magnesium particles size are also studied. The results obtained show that the presence of DNAN decreases activation energies of all reactions within the ternary compositions. Decreasing magnesium granulometry only decreases the activation energy of magnesium oxidation, but does not play a role in other reactions.
Healthcare costs and mortality associated with serious fluoroquinolone‐related adverse reactions
Authors: Kuula Laura S.M. , Backman Janne T. , Blom Marja L. 
Published: February 2022

AbstractThe aim of this study was to estimate healthcare costs and mortality associated with serious fluoroquinolone‐related adverse reactions in Finland from 2008 to 2019. Serious adverse reaction types were identified from the Finnish Pharmaceutical Insurance Pool’s pharmaceutical injury claims and the Finnish Medicines Agency’s Adverse Reaction Register. A decision tree model was built to predict costs and mortality associated with serious adverse drug reactions (ADR). Severe clostridioides difficile infections, severe cutaneous adverse reactions, tendon ruptures, aortic ruptures, and liver injuries were included as serious adverse drug reactions in the model. Direct healthcare costs of a serious ADR were based on the number of reimbursed fluoroquinolone prescriptions from the Social Insurance Institution of Finland’s database. Sensitivity analyses were conducted to address parameter uncertainty. A total of 1 831 537 fluoroquinolone prescriptions were filled between 2008 and 2019 in Finland, with prescription numbers declining 40% in recent years. Serious ADRs associated with fluoroquinolones lead to estimated direct healthcare costs of 501 938 402 €, including 11 405 ADRs and 3,884 deaths between 2008 and 2019. The average mortality risk associated with the use of fluoroquinolones was 0.21%. Severe clostridioides difficile infections were the most frequent, fatal, and costly serious ADRs associated with the use of fluoroquinolones. Although fluoroquinolones continue to be generally well‐tolerated antimicrobials, serious adverse reactions cause long‐term impairment to patients and high healthcare costs. Therefore, the risks and benefits should be weighed carefully in antibiotic prescription policies, as well as with individual patients.
Targeting coat protein II complex genes via RNA interference inhibits female adult feeding and reproductive development in the cabbage beetle Colaphellus bowringi
Authors: Tian Zhong , Guo Shuang , Zhu Fen , Liu Wen , Wang Xiao‐Ping 
Published: February 2022

AbstractBACKGROUNDThe cabbage beetle Colaphellus bowringi is a highly destructive cruciferous vegetable pest in Asia. This beetle is predominantly controlled by synthetic chemical pesticides, which leave pesticide residues on food and constitute a major hidden danger to human health. Based on preliminary research, we hypothesized that the coat protein II (COPII) complex, a primary coated vesicle that exports cargo molecules from the endoplasmic reticulum, is a promising novel target for the control of Colaphellus bowringi.RESULTSThis study investigated whether disrupting COPII using RNA interference (RNAi) affects the growth and development of Colaphellus bowringi adults. The results showed that five COPII assembly genes, Sar1, Sec23, Sec24, Sec13, and Sec31, were uniformly expressed in multiple tissues of adult female Colaphellus bowringi. Injecting double‐stranded RNA (dsRNA) against each gene induced a high RNAi efficiency by approximately 55–99%, and considerably inhibited yolk deposition and ovarian growth. Moreover, knockdown of Sar1, Sec23 and Sec24 suppressed feeding and increased mortality to 26.67%, 46.67%, and 42.22%, respectively. This was partially due to the down‐regulation of insulin/mTOR‐associated nutritional pathways. The results indicate that silencing any of the five genes responsible for COPII complex assembly represses Juvenile hormone and ecdysone signaling pathways, suggesting that vesicle transport plays a vital role in the endocrine regulation of Colaphellus bowringi females.CONCLUSIONThis study suggests that the COPII complex could be a promising RNAi target for the management of Colaphellus bowringi, which would reduce our dependence on chemical pesticides for pest control. © 2022 Society of Chemical Industry.
Physicomechanical, thermal and dielectric properties of eco‐friendly starch‐microcrystalline cellulose‐clay nanocomposite films for food packaging and electrical applications
Authors: Gürler Nedim , Torğut Gülben 
Published: February 2022

AbstractPotato starch (PS) films reinforced with microcrystalline cellulose (MCC) were prepared with casting solution, and the effect of montmorillonite (MMT) clay in different proportions (1, 3, 5 and 10 wt%) using nanofiller was established. The films were investigated by Fourier transform ınfrared (FTIR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), tensile strength, opacity, colour, water vapour permeability and solubility. Tensile strength for nanocomposite films depending on the clay content was increased significantly from 0.64 to 1.89 MPa. The water vapour permeability of nanocomposite films was improved compared to the PSMCC blend without MMT. Also, dielectric properties and electrical conductivity of films were studied. The dielectric permittivity (έ), the dielectric loss (ε˝) and the electrical conductivity (σ) increased with increasing MMT content at frequencies between 100 Hz to 10 kHz. This nanocomposite with improved functional properties could be used in potential food packaging materials and electrical applications.
Retinal vessel changes in pulmonary arterial hypertension
Authors: DuPont Mariana , Lambert Savanna , Rodriguez‐Martin Antonio , Hernandez Okaeri , Lagatuz Mark , Yilmaz Taygan , Foderaro Andrew , Baird Grayson L. , Parsons‐Wingerter Patricia , Lahm Tim , Grant Maria B. , Ventetuolo Corey E. 
Published: February 2022

AbstractPulmonary arterial hypertension (PAH) is classically considered an isolated small vessel vasculopathy of the lungs with peripheral pulmonary vascular obliteration. Systemic manifestations of PAH are increasingly acknowledged, but data remain limited. We hypothesized that retinal vascular changes occur in PAH. PAH subjects underwent retinal fluorescein angiography (FA) and routine disease severity measures were collected from the medical record. FA studies were analyzed using VESsel GENerational Analysis (VESGEN), a noninvasive, user‐interactive computer software that assigns branching generation to large and small vessels. FAs from controls (n = 8) and PAH subjects (n = 9) were compared. The tortuosity of retinal arteries was higher in PAH subjects compared to unmatched controls (1.17, 95% confidence interval: [1.14, 1.20] in PAH vs. 1.13, 95% CI: [1.12, 1.14] in controls, p = 0.01). Venous tortuosity was higher and more variable in PAH (1.17, 95% CI: [1.14, 1.20]) compared to controls (1.13, 95% CI: [1.12, 1.15]), p = 0.02. PAH subjects without connective tissue disease had the highest degree of retinal tortuosity relative to controls (arterial, p = 0.01; venous, p = 0.03). Younger PAH subjects had greater retinal arterial tortuosity, which attenuated with age and was not observed in controls. Retinal vascular parameters correlated with some clinical measures of disease in PAH subjects. In conclusion, PAH subjects exhibit higher retinal vascular tortuosity. Retinal vascular changes may track with pulmonary vascular disease progression. Use of FA and VESGEN may facilitate early, noninvasive detection of PAH.
Scalable reverse‐engineering of gene regulatory networks from time‐course measurements
Authors: Montefusco Francesco , Procopio Anna , Bates Declan G. , Amato Francesco , Cosentino Carlo 
Published: February 2022

AbstractTopological inference of biological interaction networks from experimental data is a fundamental research topic in the broad area of Systems Biology. Several algorithms presented in the literature have been devised in order to infer the topology of a network from time‐course data. The present work introduces a novel method for reverse‐engineering gene regulatory networks from time‐course experiments, which combines the instrumental variables technique for the identification of dynamical systems with a regularization strategy for dealing with over‐parametrized systems. Differently from least squares methods, the proposed approach can explicitly address the bias and nonconsistency issues that arise when dealing with time‐course measurements, thus yielding improved performance with respect to methods designed for steady‐state data. Moreover, the devised approach, which has been named RIVA (Reverse‐engineering of biological networks via Instrumental VAriables), can simultaneously exploit multiple time‐series, thus enabling one to get improved results by collecting and exploiting data from multiple experiments, and is computationally efficient, thus it can be also applied to large‐scale (in the order of thousands of nodes) networks. To analyze the applicability and effectiveness of RIVA, we performed several tests, both with simulated data and with experimental data, and compared the results against other state‐of‐the‐art inference methods designed for time‐series data.
Dewetting‐Assisted Patterning of Organic Semiconductors for Micro‐OLED Arrays with a Pixel Size of 1 µm
Authors: Zhou Xiaojie , Cai Yichen , Xu Mingsheng , Li Jianping , Sheng Chenxu , Zhang Qiuyi , Qiu Xinxia , Wang Wenchong , Xiong Shisheng , Cong Chunxiao , Qiu Zhi‐Jun , Liu Ran , Hu Laigui 
Published: February 2022

AbstractThe emergence of near‐eye displays, such as head‐mounted displays, is triggering a requirement for highly enhanced display resolution. High‐resolution micro‐displays with micro‐organic light‐emitting diodes (micro‐OLEDs) can be a preferential candidate, owing to the mature industrialization of OLEDs along with the advantages of flexibility, light weight, and ease of processing. However, micro‐OLEDs with pixel sizes down to micrometers are difficult to be achieved using conventional techniques such as fine metal mask evaporation and lithography. Here, a solution‐processing approach to pattern organic semiconductors (OSCs) for micro‐OLED arrays with the assistance of templated dewetting is demonstrated. Solvents containing organic functional materials are dewetted on the surface with hydrophobic/hydrophilic patterns to form ordered droplet arrays using dip‐coating. Subsequently, patterned OSC films are produced by effectively controlling solvent evaporation. Micro‐OLED arrays with a pixel size down to 1 µm are successfully fabricated by further deposition of emitting/electron transport layers and top electrodes. This approach can open an avenue for low‐cost manufacturing of flexible and high‐resolution micro‐displays.
Deep learning and machine learning‐based prediction of capillary water absorption of hybrid fiber reinforced self‐compacting concrete
Authors: Kina Ceren , Turk Kazim , Tanyildizi Harun 
Published: February 2022

AbstractDeep auto‐encoders and long short‐term memory methodology (LSTM) based on deep learning as well as support vector regression (SVR) and k‐nearest neighbors (kNN) based on machine learning models for the capillary water absorption prediction of self‐compacting concrete (SCC) with single and binary, ternary, and quaternary fiber hybridization were developed. A macro and two types of micro steel fibers having different aspect ratios, and PVA fiber were used. One hundred and sixty‐eight specimens produced from 24 mixtures were used in the prediction models. The input was the content of cement, fly ash, silica fume, fine and coarse aggregate, water, superplasticizer (SP), macro and micro steel fibers, PVA, time that the specimen was immersed in water, and splitting tensile strength. Water absorption was used as output. As per the ANOVA analysis of the experiment results, the most effective parameters were macro steel fiber and time for tensile strength and water absorption, respectively. Finally, binary hybridization of 1% macro steel fiber and PVA improved the splitting tensile strength while the use of PVA as binary, ternary, and quaternary fiber hybridization increased the water absorption of SCC specimens. The auto‐encoder, LSTM, SVR, and kNN models predicted the water absorption of fiber reinforced SCC with 99.99%, 99.80%, 94.57%, and 95.50% accuracy, respectively. The performance of deep autoencoder in the estimation of water absorption of fiber‐reinforced SCC was superior to the other prediction models.
Expansion of servitization in the energy sector and its implications
Authors: Park Chankook 
Published: February 2022

AbstractThe business model of as‐a‐service is rapidly spreading in the energy industry. This study aims to examine how servitization in the energy sector is progressing, what sectors are in the spotlight, and what their implications are. By understanding the servitization aspect of the energy sector, it is possible to gauge the direction of change in the energy industry. This study has reviewed various as‐a‐service types in the energy sector through new articles analytics. For a total of 6 years from 2015 to 2020, news articles containing keywords related to the energy industry and the term “as a service” were extracted from Google News using the R package. As a result, well‐known as‐a‐service models such as software‐as‐a‐service and platform‐as‐a‐service are being emphasized in the energy sector. Also, new types of services such as zero‐carbon‐as‐a‐service and resilience‐as‐a‐service have been emerging recently. With the spread of as‐a‐service, the value chain structure of the energy industry is expected to shift towards various types of services and platforms. Servitization, represented by as‐a‐service, is becoming a trend in the energy industry, and policy and regulatory support to foster the data industry and expand opportunities to demonstrate innovative technologies and services is required.This article is categorized under:
Policy and Economics > Governance and Regulation
Policy and Economics > Research and Development
A Narrative Approach to Exploring Values in Organisations
Authors: Espedal Gry , Synnes Oddgeir 
Published: February 2022

AbstractValues are often part of tacit and taken-for-granted knowledge in organisations. As such, investigating values as part of organisations and their members’ work on values can be difficult. In this chapter, we suggest a narrative approach to exploring values and values work. A narrative approach can be used to gain in-depth information on organisational activities, identity, sense-making and change. The analytical approaches of narrative research are not standardised and are instead dependent on the narratives involved and the content, aim and structure of the narratives. An organisational study is provided as an illustrative case to identify sacred stories as a form of values work manifested in creative acts of storytelling in everyday practice.