bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differentiation of multilayered automotive coatings with Fourier transform infrared spectroscopy, Raman spectroscopy and scanning electron microscope/energy dispersive Xray spectrometer
Authors: Chu Lan , Guo Chao , Zhang Qing , Wang Qing , Ge Yiwen , Hao Mingyang , Lv Jungang 
Published: June 2022

Purpose
This study aims to using Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy and scanning electron microscope/energy dispersive Xray spectrometer to identify different automotive coatings for forensic purpose.

Design/methodology/approach
Two four-layered samples in a hit-and-run case were compared layer by layer with three different methods. FTIR spectroscopy was used to primarily identify the organic and inorganic compositions. Raman spectrum and scanning electron microscope/energy dispersive Xray spectrometer (SEM-EDS) were further used to complement the FTIR results.

Findings
Two weak and tiny peaks in one layer found between two samples by FTIR, Raman microscope and SEM-EDS verified the result of differences. The study used the three instruments in combination and found it’s effective in sensing coatings, especially in the inorganic additives.

Research limitations/implications
Using these three instruments in combination is more accurate than individually in multilayered coating analysis for forensic purpose.

Practical implications
The three different instruments all present unique information on the composition, and provided similar and mutually verifiable results on the two samples.

Originality/value
With this method, scientists could identify and discriminate important coating evidences with tiny but characteristic differences.
Digital storytelling with South African youth: a critical reflection
Authors: Levine Diane , Theron Linda 
Published: June 2022

PurposeIn this paper the authors share, and reflect critically on, the experience of using digital storytelling (DS) methods in a South African township. We interrogate the innovations prompted as we operationalized DS in a context that has historically prized collectivist values and that experiences chronic resource constraints.Design/methodology/approachThe authors ask: How can DS be optimally used to understand youth resilience in a collectivist, developing context? The authors worked with 18 older adolescents (aged 18–24) during two day-long events. The authors provide detailed descriptions of the method used, and offer reflections focusing on narrative, visuals and technology-mediation.FindingsThis study concludes by sharing four key lessons learned during the project. First, revisit the definition of “story” for your context, participant group and time. Second, a slower process yields more meaningful product. Third, facilitator competence matters. Finally, advance and deeper thinking about the ways in which technology will be used leads to richer research outcomes.Originality/valueThe paper reflects on the interplay between the transactional nature of contemporary digitally-mediated methods in a low-resource setting and with a seldom-heard population, and it's relationship with the ancient local traditions of story-making and audiencing.
Rapid identification of the storage duration and species of sliced boletes using near‐infrared spectroscopy
Authors: Chen Jian , Li Jie qing , Li Tao , Liu Hong gao , Wang Yuan zhong 
Published: June 2022

AbstractBoletes are recognized as a worldwide delicacy. Adulteration of the expired and low‐value sliced boletes is a pressing problem in the supply chain of commercial sliced boletes. This study aimed at developing a rapid method to identify the storage duration and species of sliced boletes, using near‐infrared (NIR) spectroscopy. In the study, 1376 fruiting bodies of wild‐grown boletes were collected from 2017 to 2020 in Yunnan, containing four common species of edible boletes. A NIR spectroscopy‐based strategy was proposed, that is, identify the storage duration of sliced boletes to ensure that they are within the shelf life firstly; then identify the species of sliced boletes within the shelf life to evaluate their economic value. Three supervised methods, partial least squares discriminant analysis (PLS‐DA), extreme learning machine (ELM), and two‐dimensional correlation spectroscopy (2DCOS) images with residual convolutional neural network (ResNet) model were applied to identify. The results showed that PLS‐DA model cannot accurately identify the storage duration and species of sliced boletes, and the ELM model can identify the storage duration of boletes samples, but cannot accurately discriminate different species of samples. And ResNet model established by 2DCOS images showed superiority in classification performance, 100% accuracy was obtained for both the storage duration and species classification. Moreover, compared to traditional methods, the 2DCOS images with ResNet model was free of complicated data preprocessing. The results obtained in the present study indicated a promising way of combining 2DCOS images with ResNet methods, in tandem with NIR for the rapid identification of the storage duration and species of sliced boletes.Practical ApplicationIn the boletes supply chain, the method can be considered as a reliable method for testing the authenticity of boletes slices. The current study can also provide a reference for quality control of other edible mushroom.
The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: Prostate‐vesicular transrectal ultrasound reference ranges and associations with clinical, seminal and biochemical characteristics
Authors: Lotti Francesco , Frizza Francesca , Balercia Giancarlo , Barbonetti Arcangelo , Behre Hermann M. , Calogero Aldo E. , Cremers Jann‐Frederik , Francavilla Felice , Isidori Andrea M. , Kliesch Sabine , La Vignera Sandro , Lenzi Andrea , Marcou Marios , Pilatz Adrian , Poolamets Olev , Punab Margus , Godoy Maria Fernanda Peraza , Quintian Claudia , Rajmil Osvaldo , Salvio Gianmaria , Shaeer Osama , Weidner Wolfgang , Maseroli Elisa , Cipriani Sarah , Baldi Elisabetta , Degl'Innocenti Selene , Danza Giovanna , Caldini Anna Lucia , Terreni Alessandro , Boni Luca , Krausz Csilla , Maggi Mario 
Published: June 2022

AbstractBackgroundTransrectal ultrasound (TRUS) parameters are not standardized, especially in men of reproductive age. Hence, the European Academy of Andrology (EAA) promoted a multicenter study to assess the TRUS characteristics of healthy‐fertile men (HFM) to establish normative parameters.ObjectivesTo report and discuss the prostate and seminal vesicles (SV) reference ranges and characteristics in HFM and their associations with clinical, seminal, biochemical parameters.Methods188 men (35.6 ± 6.0 years) from a cohort of 248 HFM were studied, evaluating, on the same day, clinical, biochemical, seminal, TRUS parameters following Standard Operating Procedures.ResultsTRUS reference ranges and characteristics of the prostate and SV of HFM are reported herein. The mean PV was ∼25 ml. PV lower and upper limits were 15 and 35 ml, defining prostate hypotrophy and enlargement, respectively. PV was positively associated with age, waistline, current smoking (but not with T levels), seminal volume (and negatively with seminal pH), prostate inhomogeneity, macrocalcifications, calcification size and prostate arterial parameters, SV volume before and after ejaculation, deferential and epididymal size. Prostate calcifications and inhomogeneity were frequent, while midline prostatic cysts were rare and small. Ejaculatory duct abnormalities were absent. Periprostatic venous plexus size was positively associated with prostate calcifications, SV volume and arterial peak systolic velocity. Lower and upper limits of SV anterior‐posterior diameter after ejaculation were 6 and 16 mm, defining SV hypotrophy or dilation, respectively. SV total volume before ejaculation and delta SV total volume (DSTV) positively correlated with ejaculate volume, and DSTV correlated positively with sperm progressive motility. SV total volume after ejaculation was associated negatively with SV ejection fraction and positively with distal ampullas size. SV US abnormalities were rare. No association between TRUS and time to pregnancy, number of children or history of miscarriage was observed.ConclusionsThe present findings will help in better understanding male infertility pathophysiology and the meaning of specific TRUS findings.
Ten‐year follow‐up study found that motor‐free intelligence quotient declined in children with mild‐to‐moderate cerebral palsy
Authors: Coceski Monika , Stargatt Robyn , Sherwell Sarah , Abu‐Rayya Hisham M. , Reid Susan M. , Reddihough Dinah S. , Wrennall Jacquie , Hocking Darren R. 
Published: June 2022

AbstractAimThis 10‐year follow‐up study examined cognitive change in a cohort of children with cerebral palsy from preschool to adolescence at the group and individual levels.MethodsThe Wechsler Preschool and Primary Scale of Intelligence was administered to 80 children with cerebral palsy (mean = 4 years 6 months, standard deviation = 7 months) at baseline (Time 1). At 10‐year follow‐up (Time 2), 28 adolescents (mean = 14 years 6 months, standard deviation = 9 months) returned for assessment with the Wechsler Intelligence Scale for Children. Motor‐free intelligence quotient (IQ) scores were calculated and paired‐samples t‐tests and the Reliable Change Index (RCI) were used to investigate change in IQ over time.ResultsAt the group level, nonverbal IQ scores declined significantly. At the individual level, RCI indicated nine and 11 children showed a clinically significant decline in Full Scale IQ (FSIQ) and nonverbal IQ scores, respectively. Decline in FSIQ was related to a history of seizures whereas decline in nonverbal IQ was associated with higher initial IQ.ConclusionCognitive abilities in children with cerebral palsy evolve over time and selective deficits may not be observable until a later age, highlighting the importance of repeated cognitive assessment throughout childhood and adolescence.
Children included in randomised controlled trials of biologics in inflammatory bowel diseases do not represent the real‐world patient mix
Authors: Atia Ohad , Pujol‐Muncunill Gemma , Navas‐López Víctor Manuel , Orlanski‐Meyer Esther , Ledder Oren , Lev‐Tzion Raffi , Focht Gili , Shteyer Eyal , Stein Ronen , Aloi Marina , Russell Richard K. , Martin‐de‐Carpi Javier , Turner Dan 
Published: June 2022

SummaryBackgroundPatients enrolled in randomised controlled trials (RCTs) may differ from the target population due to restricted eligibility criteria.AimTo compare treatment response to biologics in routine practice for children with inflammatory bowel diseases (IBD) who would and would not have been eligible for enrolment in the regulatory RCT of the same drug.MethodsWe enrolled children with IBD who initiated adalimumab, infliximab, vedolizumab or ustekinumab. The eligibility criteria as defined in the RCT of the corresponding biologic were applied to each patient. The primary outcome was 12‐month steroid‐free remission (SFR) without switching biologics or undergoing surgery.ResultsWe screened 289 children (198 [68%] with Crohn's disease [CD], 91 [32%] with ulcerative colitis [UC]) with 326 initiations of biologics. Only 62 of 164 (38%) children with moderate–to‐severe disease would have been eligible for inclusion in the original RCTs. The SFR rate was higher in the eligible children (51%) than in the ineligible children (31%; OR 2.3 [95%CI 1.2–4.5]; p = 0.01). The main exclusion criterion was prohibited previous therapies (47%). Ineligible CD patients were older, more often had a family history of IBD and had higher levels of CRP than eligible children; in UC there were no differences between the groups.ConclusionMost children with IBD who initiate biologics would not have been eligible to be included in the corresponding regulatory RCTs. The outcomes of ineligible patients were worse than for eligible patients. Results from RCTs should be interpreted with caution when applied to clinical practice.
COVID‐19, commuter territories and the e‐bike boom
Authors: Waitt Gordon , Buchanan Ian , Lea Tess , Fuller Glen 
Published: June 2022

AbstractThe appearance and integration of e‐bikes in public space is a source of much debate worldwide. This paper offers insights to these debates by reflecting on how Deleuze and Guattari's concept of assemblage as territory helps us to understand the uptake of e‐bike commuter cycling during the Covid‐19 pandemic through empirical material from a study conducted in Sydney, Australia. Here we conceptualise commuter journeys in terms of processes of deterritorialisation and reterritorialisation; experienced through the affective territories generated by e‐bikes. The disclosure of commuter cycling sensations generated by the pandemic disruptions to commuter routines provided an important lens through which to understand the uptake of e‐bikes. The paper concludes by showing the utility of the concept of territory as a means of theorising changes to everyday mobility practices.
Optimizing haematopoietic stem and progenitor cell apheresis collection from plerixafor‐mobilized patients with sickle cell disease
Authors: Sharma Akshay , Leonard Alexis , West Kamille , Gossett Jeffrey M. , Uchida Naoya , Panch Sandhya , Stroncek David , Poston Leigh , Akel Salem , Hankins Jane S. , Fitzhugh Courtney , Hsieh Matthew M. , Kang Guolian , Tisdale John F. , Weiss Mitchell J. , Zheng Yan 
Published: June 2022

SummaryWe adjusted haematopoietic stem and progenitor cell (HSPC) apheresis collection from patients with sickle cell disease (SCD) by targeting deep buffy coat collection using medium or low collection preference (CP), and by increasing anticoagulant–citrate–dextrose–solution A dosage. In 43 HSPC collections from plerixafor‐mobilized adult patients with SCD, we increased the collection efficiency to 35.79% using medium CP and 82.23% using low CP. Deep buffy coat collection increased red blood cell contamination of the HSPC product, the product haematocrit was 4.7% with medium CP and 6.4% with low CP. These adjustments were well‐tolerated and allowed efficient HSPC collection from SCD patients.
International Alliance of Urolithiasis guideline on retrograde intrarenal surgery
Authors: Zeng Guohua , Traxer Olivier , Zhong Wen , Osther Palle , Pearle Margaret S. , Preminger Glenn M , Mazzon Giorgio , Seitz Christian , Geavlete Petrisor , Fiori Cristian , Ghani Khurshid R. , Chew Ben H. , Git Kah Ann , Vicentini Fabio Carvalho , Papatsoris Athanasios , Brehmer Marianne , Martinez Juan Lopez , Cheng Jiwen , Cheng Fan , Gao Xiaofeng , Gadzhiev Nariman , Pietropaolo Amelia , Proietti Silvia , Ye Zhangqun , Sarica Kemal 
Published: June 2022

ObjectivesTo set out the second in a series of guidelines on the treatment of urolithiasis by the International Alliance of Urolithiasis that concerns retrograde intrarenal surgery (RIRS), with the aim of providing a clinical framework for urologists performing RIRS.Materials and MethodsAfter a comprehensive search of RIRS‐related literature published between 1 January 1964 and 1 October 2021 from the PubMed database, systematic review and assessment were performed to inform a series of recommendations, which were graded using modified GRADE methodology. Additionally, quality of evidence was classified using a modification of the Oxford Centre for Evidence‐Based Medicine Levels of Evidence system. Finally, related comments were provided.ResultsA total of 36 recommendations were developed and graded that covered the following topics: indications and contraindications; preoperative imaging; preoperative ureteric stenting; preoperative medications; peri‐operative antibiotics; management of antithrombotic therapy; anaesthesia; patient positioning; equipment; lithotripsy; exit strategy; and complications.ConclusionThe series of recommendations regarding RIRS, along with the related commentary and supporting documentation, offered here should help provide safe and effective performance of RIRS.
β‐Arrestin‐biased proteinase‐activated receptor‐2 antagonist C781 limits allergen‐induced airway hyperresponsiveness and inflammation
Authors: Schiff Hillary V. , Rivas Candy M. , Pederson William P. , Sandoval Estevan , Gillman Samuel , Prisco Joy , Kume Moeno , Dussor Gregory , Vagner Josef , Ledford Julie G. , Price Theodore J. , DeFea Kathryn A. , Boitano Scott 
Published: June 2022

Background and PurposeAsthma is a heterogenous disease strongly associated with inflammation that has many different causes and triggers. Current asthma treatments target symptoms such as bronchoconstriction and airway inflammation. Despite recent advances in biological therapies, there remains a need for new classes of therapeutic agents with novel, upstream targets. The proteinase‐activated receptor‐2 (PAR2) has long been implicated in allergic airway inflammation and asthma and it remains an intriguing target for novel therapies. Here, we describe the actions of C781, a newly developed low MW PAR2 biased antagonist, in vitro and in vivo in the context of acute allergen exposure.Experimental ApproachA human bronchial epithelial cell line expressing PAR2 (16HBE14o‐ cells) was used to evaluate the modulation in vitro, by C781, of physiological responses to PAR2 activation and downstream β‐arrestin/MAPK and Gq/Ca2+ signalling. Acute Alternaria alternata sensitized and challenged mice were used to evaluate C781 as a prophylactically administered modulator of airway hyperresponsiveness, inflammation and mucus overproduction in vivo.Key ResultsC781 reduced in vitro physiological signalling in response to ligand and proteinase activation. C781 effectively antagonized β‐arrestin/MAPK signalling without significant effect on Gq/Ca2+ signalling in vitro. Given prophylactically, C781 modulated airway hyperresponsiveness, airway inflammation and mucus overproduction of the small airways in an acute allergen‐challenged mouse model.Conclusion and ImplicationsOur work demonstrates the first biased PAR2 antagonist for β‐arrestin/MAPK signalling. C781 is efficacious as a prophylactic treatment for allergen‐induced airway hyperresponsiveness and inflammation in mice. It exemplifies a key pharmacophore for PAR2 that can be optimized for clinical development.
Caspase‐4/11 is critical for angiogenesis by repressing Notch1 signalling via inhibiting γ‐secretase activity
Authors: Fan Linlin , Liu Hao , Zhu Guofu , Singh Shekhar , Yu Ze , Wang Shumin , Luo Hong , Liu Shiying , Xu Yawei , Ge Junbo , Jiang Dongyang , Pang Jinjiang 
Published: June 2022

Background and PurposeNotch1 activation mediated by γ‐secretase is critical for angiogenesis. GeneCards database predicted that Caspase‐4 (CASP4, with murine ortholog CASP11) interacts with presenilin‐1, the catalytic core of γ‐secretase. Therefore, we investigated the role of CASP4/11 in angiogenesis.Experimental ApproachIn vivo, we studied the role of Casp11 in several angiogenesis mouse models using Casp11 wild‐type and knockout mice. In vitro, we detected the effects of CASP4 on endothelial functions and Notch signalling by depleting or overexpressing CASP4 in human umbilical vein endothelial cells (HUVECs). The functional domain responsible for the binding of CASP4 and presenilin‐1 was detected by mutagenesis and co‐immunoprecipitation.Key ResultsCasp11 deficiency impaired adult angiogenesis in ischaemic hindlimbs, melanoma xenografts and Matrigel plugs, but not the developmental angiogenesis of retina. Bone marrow transplantation revealed that the pro‐angiogenic effect depended on CASP11 derived from non‐haematopoietic cells. CASP4 expression was induced by inflammatory factors and CASP4 knockdown decreased cell viability, proliferation, migration and tube formation in HUVECs. Mechanistically, CASP4/11 deficiency increased Notch1 activation in vivo and in vitro, while CASP4 overexpression repressed Notch1 signalling in HUVECs. Moreover, CASP4 knockdown increased γ‐secretase activity. The γ‐Secretase inhibitor DAPT restored the effects of CASP4 siRNA on Notch1 activation and angiogenesis in HUVECs. Notably, the catalytic activity of CASP4/11 was dispensable. CASP4 directly interacted with presenilin‐1 through the caspase recruitment domain (CARD).Conclusions and ImplicationsThese findings reveal a critical role of CASP4/11 in adult angiogenesis and make this molecule a promising therapeutic target for angiogenesis‐related diseases in the future.
Depositional and diagenetic processes in volcanic matrix‐rich sandstones from the Shanxi and Shihezi formations, Ordos Basin, China: Implication for volcano‐sedimentary systems
Authors: Cui Hang , Zhu Shifa , Tan Mingxuan , Tong Huan 
Published: June 2022

AbstractVolcanic eruptions can provide large amounts of sedimentary materials and expose fluvial valleys or lakes to catastrophic hyperpycnal flood events, but this process has not been documented in detail. The Ordos Basin Permian fluvio‐deltaic system reveals evidence for abundant volcanism linked to the tectonic evolution of orogenic belt around the basin and provides a ‘natural laboratory’ for investigating hyperpycnal flows associated with volcanic activity. This study analysed volcanic matrix‐rich sandstone (VMS) samples for petrology, mineralogy and geochemistry in order to address current and uncertain volcanogenic material provenance explanations and the lack of systematic investigations into the depositional and diagenetic processes of volcanic related sediments in the southwestern basin. By combining tectonic background surveys, detrital zircon geochronology and spatial distribution of volcanogenic materials, it was found that volcanogenic materials were not derived from the Yinshan‐Yanshan Orogenic Belt (YYOB) as previously thought, but instead evidence a southwestern origin from the North Qinling Orogenic Belt (NQOB). Volcanogenic materials retained in the provenance area during frequent volcanic eruptions were transported to the basin via fluvial systems shortly after the eruption. The associated sediments meet the criterion for hyperpycnites based on lithofacies associations, suggesting the occurrence of hyperpycnal flows during the deposition of VMS. During the subsequent burial stage, the VMS became three distinct types defined by their volcanic matrix content and have similar paragenetic sequences but different diagenetic intensities. The differing content of authigenic minerals in the three types was closely related to the sandstone pore structure characteristics and the evolution of volcanic‐matrix alteration materials. This article proposes a possible explanation for the previously unidentified tectonothermal events in the NQOB during the Permian, validating and reinforcing the theoretical work of hyperpycnal flow. This contribution provides new insights and understanding of the depositional and diagenetic processes of lacustrine basins with similar tectonic settings.
An economic analysis of production efficiency: Evidence from Irish farms
Authors: Chavas Jean‐Paul , Läpple Doris , Barham Bradford , Dillon Emma 
Published: June 2022

AbstractThe objective of this paper is to investigate the economics of production efficiency of dairy farms, with a specific focus on the role of agricultural policy. Our analysis is based on a representative sample of Irish dairy farms, ranging from 2000 to 2018, which includes a period of major change in EU dairy policy. Based on a multi‐input multi‐output production system, we first estimate technical, allocative, scale and scope efficiencies. We find significant heterogeneity in technical and allocative efficiencies, which change over time. We also calculate shadow prices of milk quota, which suggest that milk quotas restricted many farmers and limited their ability to produce milk. Finally, we explore determinants of technical, allocative, scale and overall inefficiencies using random panel‐data censored regression. We find that subsidies are positively associated with farm efficiency, but the effects vary over distinct quota abolition periods. Overall, our empirical findings indicate that agricultural policy had important effects on the managerial effectiveness of farmers.