bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug-Related Deaths in China: An Analysis of a Spontaneous Reporting System
Authors: Li Haona , Deng Jianxiong , Yu Peiming , Ren Xuequn 
Published: February 2022

Background: Adverse drug reactions with an outcome of death represent the most serious consequences and are inherently important for pharmacovigilance. The nature and characteristics of drug-related deaths are to a large extent unknown in the Chinese population. This study aims to characterize drug-related deaths by analysis of individual case safety reports (ICSRs) with an outcome of death in China.Methods: The characteristics of death ICSRs were analyzed by descriptive statistics of a large multi-provincial pharmacovigilance database in China.Results: There were 1,731 ICSRs with an outcome of death, representing 0.95% of all serious cases and 0.05% of all reported ICSRs. Most death ICSRs (78.57%) were reported by medical institutions. Only 16.00% of death ICSRs were reported by manufacturers or distributors. The reporting rate of death ICSRs in the age group of 0–4 years was significantly higher than patients aged 5–64 years. Patients aged over 64 years had the highest reporting rate of death ICSRs. Male patients generally had a higher reporting rate of death ICSRs than female patients. However, the reporting rate of female patients exceeded that of male patients in the age group of 20–34 years. Among 3,861 drugs implicated, ceftriaxone sodium with 146 (3.78%) records of death ranked first. Dexamethasone with 131 (3.39%) records of death ranked second. Qingkailing, an injectable traditional Chinese medicine with 75 (1.94%) records of death, ranked the fifth most frequently implicated medicine.Conclusion: Young children and elderly patients have a higher risk of drug-related deaths than patients aged 5–64 years. Female patients generally have a lower risk of drug-related deaths than male patients. However, female patients of reproductive age (aged 20–34 years) have a higher risk of drug-related deaths than male patients, hinting that physiological changes and drug uses for child bearing, giving birth, or birth control may significantly increase the risk of death for female patients aged 20–34 years. This paper suggests more research on the safe use of drugs for young children, elderly patients, and female patients of reproductive ages. Pharmacovigilance databases can be valuable resources for comprehensive understanding of drug-related problems.
Increasing Aspartoacylase in the Central Amygdala: The Common Mechanism of Gastroprotective Effects of Monoamine-Based Antidepressants Against Stress
Authors: Yao Kaiyun , Cao Linyu , Ding Hongwan , Gao Yinge , Li Tiegang , Wang Guibin , Zhang Jianjun 
Published: February 2022

Monoamine-based antidepressants can prophylactically protect against stress-induced gastric ulcers. Although the central nucleus of amygdala (CeA) has been shown to modulate the severity of stress ulcers, little is known about the molecular mechanisms underlying the gastroprotective effect of this kind of drugs. Here, we first used proton magnetic resonance spectroscopy, a non-invasive tool, to explore the change of neurometabolites of the CeA of rats pretreated with the duloxetine of selective serotonin-norepinephrine reuptake inhibitors during 6 h of water-immersion restraint stress (WIRS). Duloxetine decreased N-acetyl-aspartate/creatine ratio (NAA/creatine) in CeA after WIRS, which was paralleled by the amelioration of gastric lesions. Meanwhile, the gastric ulcer index was negatively correlated with reduced NAA/creatine. Furthermore, the intra-CeA infusion of NAA aggravated WIRS-induced gastric mucosa damage, which suggested the crucial role of reduced NAA. Western blotting was performed to identify the specific enzymes responsible for the change of the contents of NAA at 0.5 h/3 h/6 h after WIRS, considering the preventative gastric protection of duloxetine. The NAA-catabolizing enzyme aspartoacylase (ASPA) was the only enzyme downregulated by 0.5 h WIRS and upregulated by duloxetine. Moreover, overexpressing ASPA in CeA alleviated stress ulcers. Additionally, all of the other three monoamine-based antidepressants, the fluoxetine of selective serotonin reuptake inhibitors, the amitriptyline of tricyclic agents, and the moclobemide of MAOs, increased ASPA expression in CeA. Together, these results indicate that increasing ASPA to hydrolyze NAA in CeA is a common mechanism of gastroprotective effects against stress exerted by monoamine-based antidepressants, and ASPA is a shared target more than monoamine regulation for this kind of drugs.
Gender Differences in Perceived Stress and Its Relationship to Telomere Length in Costa Rican Adults
Authors: Méndez-Chacón Ericka 
Published: February 2022

IntroductionStress is associated with disease and reduced leukocyte telomere length (LTL). The objective of this research is to determine if self-perceived stress is associated with telomere length in Costa Rican adults and the gender differences in this association. Findings may help explain how some populations in apparent socioeconomic disadvantage and with limited access to specialized medical services have a remarkably high life expectancy.MethodologyData come from the pre-retirement cohort of the Costa Rican Longevity and Healthy Aging Study (CRELES), a population based survey conducted in the households to 2,327 adults aged 53 to 66 years. The DNA to measure LTL was extracted from blood cells in laboratories of the University of Costa Rica whereas the Blackburn laboratory at the University of California performed the telomere length measurement applying the quantitative polymerase chain reaction (Q-PCR). The relationship between telomere length and perceived stress was measured using least-squares multiple regression. Perceived stress was measured by a set of questions about family, job, finances and, health reasons to be stressed. Models included the control variables: (1) age and sex of the participant, (2) whether he or she resides in the Nicoya area, a “blue zone” known for its high longevity, and (3) the aforementioned sociodemographic, health and lifestyles characteristics.ResultsStress perception and LTL are significantly different by sex. Women perceived higher stress levels than men in almost all aspects studied, except work. Women have significantly longer telomeres. Shorter telomeres are significantly associated with caregiving stress in men and with parental health concerns in women. Counter-intuitive telomere lengthenings were observed among women who feel stressed about caring for family members; and among men who feel stressed due to their family relationships as well as concerns about their own health.DiscussionResults confirm that people with self-perceived stress due to caregiving or health issues have shorter telomeres. The relationship between stress and telomere length differs between men and women. Gender relations exert a strong modifier effect on the relationship between stress and LTL: gender is related to perceived stress, telomere length, and apparently also to the way stress and LTL are related.
Predictors of Suicide Ideation and Attempt Planning in a Large Sample of New Zealand Help-Seekers
Authors: Shepherd Daniel , Taylor Stephen , Csako Rita , Liao An-Tse , Duncan Renee 
Published: February 2022

AimSuicide is a major public health concern worldwide. The present study explores the risk factors for suicide ideation and suicide attempt planning by analyzing anonymized data collected by a New Zealand telephone helpline.MethodA nation-wide helpline, Lifeline Aoteroa, provided data from distressed callers obtained from May 2017 to April 2018. The analyzed sample consisted of 32,889 counseling calls of clients with a wide range of presenting issues. Frequency analysis and multivariable logistic regression were adopted to determine risk and protective factors associated with two types of suicide behaviors: suicide ideation and suicide planning.ResultsRisk factors for suicide ideation and suicide planning included: hopelessness, sadness, fear, not coping with symptoms of mental health issues, mild/moderate severity self-harm, severe self-harm, urge to self-harm, alcohol and/or drug addiction, suicide in family, sexual domestic abuse. The adjusted odds rations for these risk factors ranging from 1.31 to 16.42. Protective factors included feelings of hope or joy, the opportunity to talk and, unexpectedly, feeling anxious or stuck. The adjusted odds ratios for protective factors ranged from 0.15 to 0.75.ConclusionRisk factors were identified for both suicide ideation and for suicide attempt planning. While some of these risk factors have been reported in existing literature, there are also risk factors unique to the present study that could inform and improve suicide-screening procedures administered by clinicians or helplines.
Canadian 24-h Movement Guidelines, Life Stress, and Self-Esteem Among Adolescents
Authors: Sampasa-Kanyinga Hugues , Lien Amanda , Hamilton Hayley A. , Chaput Jean-Philippe 
Published: February 2022

BackgroundAdolescence is often considered a period of heightened stress, and healthy active living behaviors may help those experiencing it to better cope with life stressors and increase their self-esteem. The 24-h movement guidelines for children and adolescents recommend ≥60 min per day of moderate-to-vigorous physical activity, ≤ 2-h per day of recreational screen time, and 9–11-h of sleep per night for school-aged children or 8–10-h per night for adolescents. The objective of this study was to examine the association of meeting the 24-h movement guidelines with life stress and self-esteem among students in Ontario, Canada.MethodsSelf-reported data on movement behaviors, life stress and self-esteem were derived from the 2019 cycle of the Ontario Student Drug Use and Health Survey, a cross-sectional and province-wide survey of students in grades 7–12 aged 11 to 20 years (N = 6,932). Multivariable ordered logistic regression analyses were adjusted for the complex sample design of the survey and for important covariates.ResultsOverall, meeting all combinations of movement behavior recommendations were associated with lower life stress and better self-esteem compared with meeting none of the recommendations, except meeting the physical activity only or screen time only recommendations that were not associated with lower life stress. Meeting all 3 recommendations was associated with lower life stress (OR: 0.40; 95 CI: 0.30–0.53) and better self-esteem (OR: 0.29; 95% CI: 0.21–0.40). There was a dose-response gradient between the number of recommendations met (3 &gt; 2 &gt; 1) and lower life stress (p &lt; 0.001) and higher self-esteem (p &lt; 0.001), with meeting all 3 recommendations being the best combination.ConclusionsThese findings suggest that meeting the recommendations of the 24-h movement guidelines is associated with lower life stress and better self-esteem among adolescents.
Psychometric Properties of the Arabic Version of the Problem Areas in Diabetes Scale in Primary Care
Authors: Sayed Ahmed Hazem A. , Mohamed Samar Farag , Elotla Sally Fawzy , Mostafa Mona , Shah Jaffer , Fouad Ahmed Mahmoud 
Published: February 2022

BackgroundThe Problem Areas in Diabetes (PAID) scale is a reliable and valid tool that is widely used for diabetes-distress screening, but the Arabic version of the scale lacks validity and reliability analysis in primary healthcare (PHC) patients. Our study aimed to evaluate the psychometric properties of the Arabic version of the PAID (AR-PAID) scale among Egyptian patients with type 2 diabetes mellitus (T2DM) in PHC settings.MethodsWe conducted a cross-sectional study on a convenience sample of 200 patients from six rural PHC settings in the Ismailia governorate. The confirmatory factor analysis (CFA) was performed to test the goodness-of-fit to the predefined models of the PAID. Convergent construct was evaluated through correlations with the Arabic versions of the Patient Health Questionnaire 9 (PHQ-9), Generalized Anxiety Disorder Scale (GAD-7), and 5-item World Health Organization Well-Being Index (WHO-5), additionally glycated hemoglobin (HbA1c) levels. Discriminant validity was evaluated through associations with patients' sociodemographic and clinical characteristics. Reliability was evaluated through internal consistency (Cronbach's α) and test-retest reliability analysis (intraclass correlation coefficient, ICC).ResultsThe CFA demonstrated the best fit for a four-factor model. The AR-PAID was significantly correlated with the following measures: PHQ-9 (rho = 0.71, p &lt; 0.001), GAD-7 (rho = 0.50, p &lt; 0.001), WHO-5 (rho = −0.69, p &lt; 0.001), and HbA1c (rho = 0.36, p &lt; 0.001), supporting sound convergent validity. Discriminant validity was satisfactory demonstrated. Internal consistency was excellent (α = 0.96) and test-retest reliability was stable (ICC = 0.97).ConclusionsThe AR-PAID scale is a valid and reliable instrument for diabetes-distress screening in primary care patients with T2DM that can be used in clinical settings and research. Further research is needed to validate short forms of the AR-PAID scale.
The Impact of Cognition on Motor Learning and Skill Acquisition Using a Robot Intervention in Infants With Cerebral Palsy
Authors: Chandrashekhar Raghuveer , Wang Hongwu , Rippetoe Josiah , James Shirley A. , Fagg Andrew H. , Kolobe Thubi H. A. 
Published: February 2022

Background: Cerebral Palsy (CP) is a neurodevelopmental disorder that encompasses multiple neurological disorders that appear in infancy or early childhood and persist through the lifespan of the individual. Early interventions for infants with CP utilizing assisted-motion robotic devices have shown promising effects in rehabilitation of the motor function skills. The impact of cognitive function during motor learning and skill acquisition in infants using robotic technologies is unclear.Purpose: To assess the impact of cognitive function of infants with and without CP on their motor learning using the Self-Initiated Prone Progression Crawler (SIPPC) robot.Methods: Statistical analysis was conducted on the data obtained from a randomized control trial in which the movement learning strategies in infants with or at risk for CP was assessed during a 16-week SIPPC robot intervention. Cognitive function was measured by the Bayley scales of Infant and Toddler Development–Third edition (Bayley-III) and motor function was measured by the Movement Observation Coding Scheme (MOCS). The infants were categorized into three distinct groups based on their cognitive scores at baseline: “above average” (n1 = 11), “below average” (n2 = 10), and “average” (n3 = 26). Tri-weekly averages of the MOCS scores (observations at five time points) were used for the analyses. This study involved computing descriptive statistics, data visualization, repeated measures analysis of variances (rmANOVA), and survival analyses.Results: The descriptive statistics were calculated for the MOCS and Bayley III scores. The repeated measures ANOVAs revealed that there was a statistically significant effect of time (p &lt; 0.0001) on scores of all subscales of the MOCS. A statistically significant effect of interaction between group and time (p &lt; 0.05) was found in MOCS scores of subscales 1 and 2. The survival analyses indicated that infants in different cognition groups significantly differed (p &lt; 0.0001) in their ability to achieve the crawling milestone within the 16-week intervention period.Conclusion: The findings in this study reveal the key movement strategies required to move the SIPPC robot, assessed by the MOCS, vary depending on the infants’ cognition. The SIPPC robot is well-matched to cognitive ability of infants with CP. However, lower cognitive ability was related to delayed improvement in their motor skills.
The Correlation Between Intra-Abdominal Pressure and Tolerance to Postoperative Hyperthermic Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei
Authors: Yu Junye , Yu Lifei , Su Lin , Shi Ying 
Published: February 2022

ObjectiveTo evaluate the correlation between pain intensity and comfort level in patients with pseudomyxoma peritoneum (PMP) before and after hyperthermic intraperitoneal chemotherapy (HIPEC).MethodsFrom June 2018 to June 2019, patients who underwent HIPEC for PMP after surgical treatment in our institute were selected. The intra-abdominal pressure (IAP) and pain intensity (PI) before and after HIPEC were recorded, and the correlation between them was analyzed.ResultsSeventy-four patients received HIPEC 253 times. IAP and PI were significantly higher after perfusion than before perfusion (P &lt; 0.05). When IAP &lt; 12 cmH2O, the change of PI was not correlated to the increase of IAP, and the patient tolerated the treatment. However, when IAP &gt; 12 cmH2O, the increase of PI was significantly associated with IAP and cause significant discomfort during the treatment.ConclusionIAP may be a monitoring index for the comfort of PMP patients during the postoperative HIPEC treatment.
Transabdominal Laparoscopic Ureteroureterostomy With the Intraoperative Retrograde Ureteroscopy-Assisted Technique for Multiple Ureteral Polyps: A Single-Center 10 Years Experiences
Authors: Xia Weiping , Chen Xiang , Li Bingsheng , Chen Hequn , Zhu Zewu , He Yao , Gan Yu , Zhang Bo , Wang Kangning , Li Yang , Jiang Zexiang , Long Jin , Chen Zhi 
Published: February 2022

BackgroundThe purpose of this study was to report our experience in treating multiple ureteral polyps with transabdominal laparoscopic ureteroureterostomy (LAP-UU) with intraoperative retrograde ureteroscopy (RU)-assisted technique.MethodsThe data of 32 patients who underwent transabdominal LAP-UU with the intraoperative RU-assisted technique due to multiple ureteral polyps between January 2011 and March 2021 were reviewed at our institute. After administration of anesthesia, patients were placed in a passive position and underwent a three-port transabdominal laparoscopy with RU. Detailed data were reviewed, such as demographic characteristics, intraoperative outcomes, postoperative data, complications, and pathology reports.ResultsThirty-two patients were diagnosed with multiple ureteral polyps underwent this surgery method at our institution. The mean duration of symptoms at the time of diagnosis was approximately 7.1 months. The mean age of patients was 42.4 years, with men accounting for 68.8% (22/32), lesion of left for 56.3% (18/32), and the upper ureter for 62.5% (20/32). Furthermore, the median length of the polyps was 3.6 cm, the mean operative time was 174.6 min, and the estimated blood loss (EBL) was about 86.8 ml. The mean time to begin a liquid diet and to be out of bed were 1.7 and 2.3 days, respectively. The average length of hospital stay was 6.3 days. The ureteral stent was removed by cystoscope 2–3 months after surgery. Follow-up duration ranged from 3 to 112 months and none of the patients required another surgery for recurrence.ConclusionTransabdominal LAP-UU combined with the intraoperative RU-assisted technique is an effective, safe, and reliable surgical option for patients with multiple ureteral polyps. Further long-term follow-up is recommended.
Description of Crinitomyces reliqui gen. nov., sp. nov. and Reassignment of Trichosporiella flavificans and Candida ghanaensis to the Genus Crinitomyces
Authors: Sakpuntoon Varunya , Péter Gábor , Groenewald Marizeth , Dlauchy Dénes , Limtong Savitree , Srisuk Nantana 
Published: February 2022

The systematic position of 16 yeast strains isolated from Thailand, Hungary, The Netherlands, and the Republic of Poland were evaluated using morphological, physiological, and phylogenetic analyses. Based on the similarity of the D1/D2 domain of the LSU rRNA gene, the strains were assigned to two distinct species, Trichosporiella flavificans and representatives of a new yeast species. Phylogenetic analyses revealed that Candida ghanaensis CBS 8798T showed a strong relationship with the aforementioned two species. The more fascinating issue is that Candida and Trichosporiella genera have been placed in different subphyla, Saccharomycotina and Pezizomycotina, respectively. The close relationship between Trichosporiella flavificans, Candida ghanaensis and the undescribed species was unexpected and needed to be clarified. As for morphological and physiological characteristics, the three yeast species shared a hairy colony appearance and an ability to assimilate 18 carbon sources. Based on phylogenetic analyses carried out in the present study, Crinitomyces gen. nov. was proposed to accommodate the new yeast species, Crinitomyces reliqui sp. nov. (Holotype: TBRC 15054, Isotypes: DMKU-FW23-23 and PYCC 9001). In addition, the two species Trichosporiella flavificans and Candida ghanaensis were reassigned to the genus Crinitomyces as, Crinitomyces flavificans (Type: CBS 760.79) comb. nov. and Crinitomyces ghanaensis (Type: CBS 8798) comb. nov., respectively.
High-peak-power and wavelength tunable acousto-optic Q-switched Er:ZBLAN fiber laser
Authors: Chen Tenghui , Yao Weichao , Uehara Hiyori , Ma Chunyang , Sohail Muhammad , Zhang Chunxiang , Ge Yanqi , Fan Dianyuan , Liu Jun 
Published: February 2022

Abstract
We demonstrate Q-switching operation of a single-moded mid-infraredEr3+-doped ZBLAN (Er:ZBLAN) fiber laser based on an acousto-optic modulator. The fiber laser can produce steady Q-switched pulses as short as 24.8 ns at an average output power of 45.7 mW with a single transverse mode, corresponding to a peak power of 18.4 kW. In addition, a wavelength tuning range from 2715.4 to 2790.4 nm is also achieved in the Q-switching regime at the repetition rate of 1 kHz. The experimental results demonstrate the huge potential of producing mid-infrared energetic and wavelength tunable short-pulses in an actively Q-switched Er:ZBLAN fiber laser.
Perancangan Sistem Informasi Resume Medis Pasien Rawatinap di Siloam Hospitals Purwakarta
Authors: Juli Saputra Risa , Setiatin Sali , Syahidin Yuda 
Published: February 2022

Rumah sakit merupakan fasilitas pelayanan kesehatan yang memberikan pelayanan secara lengkap. Salah satu parameter untuk menentukan mutu pelayanan kesehatan di rumah sakit adalah data atau informasi dari rekam medis, khususnya pada resume medis dan untuk mengetahui kelengkapan pengisian resume medis perlu dilakukan analisis. Namun penginputan analisis secara manual dan belum adanya sistem khusus dapat mengurangi efesien dan efektifitas waktu, untuk itu penelitian ini dibuat bertujuan merancang sistem informasi khusus analisis resume medis pasien rawat inap agar mempermudahkan petugas didalam mengalisis. Penelitian ini menggunakan metode kualitatif dengan metode pengembangan perangkat lunak air terjun / Waterfall dan lokasi penelitian ini adalah di Siloam Hospitals Purwakarta dengan menggunakan teknik pengumpulan data observasi dan wawancara. Masalah yang terjadi dalam menganalisis kelengkapan resume masih dikerjakan dengan input manual pada exel, seperti menginput nomor rekam medis, nama pasien, nama dokter dan bahkan jumlah hari perawatan masih dihitung manual sehingga tidak menutup kemungkinan akan terjadinya kekeliruan dalam penginputan. Adapun hasil observasi persentase dari 200 sampel berkas resume medis rawat inap di Siloam Hospitals Purwakarta adalah 65% untuk berkas yang lengkap dan 35% untuk yang tidak lengkap. saran yang dapat diberikan oleh penulis agar rumah sakit dapat meningkatkan sistem informasi yang lebih modern untuk penginputan dan pengolahan data.