bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered spontaneous brain activities in maintenance hemodialysis patients with cognitive dysfunction and the construction of cognitive function prediction models
Authors: Sun Qing , Zheng Jiahui , Zhang Yutao , Wu Xiangxiang , Jiao Zhuqing , Xu Lifang , Shi Haifeng , Liu Tongqiang 
Published: October 2022

Abstract
Trial registration:The study was approved by the Ethics Committee of the Second People's Hospital of Changzhou City (KY032-01).
OBJECTIVE: To measure changes in spontaneous brain activity in maintenance hemodialysis patients (MHD) with cognitive impairment (CI) base on resting-state functional magnetic resonance imaging (rs-fMRI) and predict cognitive function in maintenance hemodialysis patients by combining spontaneous brain activity and clinical indicators.
METHODS: We selected 50 patients undergoing maintenance hemodialysis at the Second People's Hospital of Changzhou City from September 2020 to December 2021; 28 healthy volunteers were recruited during the same period, and all subjects underwent neuropsychological testing and rs-fMRI. MHD patients were divided into MHD-CI group and MHD-NCI group according to neuropsychological testing score. Data analysis was performed after image preprocessing to explore spontaneous brain activity changes in differential brain regions of MHD-CI patients and to analyze the correlation between spontaneous brain activity and clinical variables. Back propagation neural network (BPNN) was used to predict cognitive function.
RESULTS: Compared with the MHD-NCI group, the patients with MHD-CI had more severe anemia and higher urea nitrogen levels, the lower mALFF values in the left postcentral gyrus, lower mfALFF values in the left inferior temporal gyrus, and greater mALFF values in the right caudate nucleus (p < 0.05). Correlation analysis showed that the mALFF values in the left postcentral gyrus of MHD patients were significantly positively correlated with hemoglobin levels (r = 0.551, p = 0.000) and MOCA scores (r = 0.457, p = 0.001), negatively correlated with urea nitrogen (r = –0.519, p = 0.000). left temporal inferior gyrus mfALFF values were significantly negatively correlated with urea nitrogen levels (r = –0.523, p = 0.000) and positively correlated with MOCA scores (r = 0.295, p = 0.038). The right caudate nucleus mALFF values were negatively correlated with MOCA scores (r = -0.455, p = 0.001). Based on quantifiable influencing factors, we construct different BPNN prediction models, indicating that the diagnostic efficacy of the model which inputs were hemoglobin, urea nitrogen and mALFF value in the left central posterior gyrus is optimal(R2=0.8054).
CONCLUSION: In summary, the left inferior temporal gyrus and left postcentral gyrus might be the critical regions affecting cognitive function in MHD-CI patients, and correction of anemia and adjustment of urea nitrogen levels might help prevent CI in MHD patients. Combined with rs-fMRI not only reveals the neurophysiological mechanism of cognitive impairment, but also can serves as a neuroimaging marker for the diagnosis and evaluation of cognitive impairment in patients with MHD.
Aldehyde Dehydrogenase 1 paralogues ALDH1A1 and ALDH1A3 in satellite cells are essential for myogenic differentiation
Authors: Steingruber Laura , Krabichler Florian , Franzmeier Sophie , Wu Wei , Koch Marco , Schlegel Jürgen 
Published: October 2022

Abstract
Satellite cells (SCs) are stem cells and myogenic determinants of skeletal muscles. Aldehyde Dehydrogenase 1 (ALDH1) activity correlates with myogenic properties of SCs, and the paralogues ALDH1A1 and ALDH1A3 are expressed in human SCs. ALDH1 serves as the pacemaker enzyme in retinoic acid (RA)-driven differentiation and acts as a ROS scavenger to protect against oxidative damage. However, the underlying molecular mechanisms of ALDH1 regulation in SCs and its impact on RA-driven myogenesis remain elusive.
We analysed the impact of ALDH1A1 and ALDH1A3 activity on myogenesis of the murine myoblast cell line C2C12. Both, ALDH1A1 and ALDH1A3 are pivotal factors in myogenic differentiation, since CRISPR/Cas9-edited single ALDH1a1 or ALDH1a3 knock-out, respectively, impaired experimentally induced myogenic differentiation, as assessed by serum withdrawal, while successive recombinant re-expression of ALDH1A1 or ALDH1A3, respectively, in the corresponding ALDH1 paralogue single knock-out cell lines, recovered the differentiation potential. Loss of differentiation in both single knock-out cell lines was restored by treatment with RA analogue TTNPB, while RA receptor antagonization by AGN 193109 inhibited differentiation of wildtype cell lines, supporting the idea that RA receptor-signalling is pivotal for myogenic differentiation which is accomplished by the ALDH1 paralogues. However, overexpression of ALDH1 paralogues, or disulfiram treatment to inhibit ALDH1 enzymatic activity, not only increased ALDH1A1 and ALDH1A3 protein levels but also induced subsequent differentiation of C2C12 cells independently from serum withdrawal, indicating that ALDH1 dependent myogenic differentiation relies on different cellular conditions, and that yet unknown, RA-independent signalling pathways, may also be involved in myogenic differentiation.
OMA1 maintains the stemness of glioma stem cells by inducing mitochondrial fission/fusion imbalance
Authors: Li Jun jun , Xiong Cui , Zhu Kai , Jiang Cheng , Wang Min jie , Zhou Zi jie , Tang Nan , Wang Si qi , Shu Peng wei , Yuan Hong liang , Xiong Zhi yong , Li Jin song , Liang Tao , Wang Xuan , Jiang Xiao bing 
Published: October 2022

AbstractBackground:Cancer stem cells (CSCs) are the main cause of tumorigenesis, recurrence, and drug resistance and ultimately result in poor clinical outcomes.An imbalance in mitochondrial dynamics is an important manifestation of tumorigenesis. Based on increasing evidence, excessive fission and reduced fusion are common features of many tumors. However, the precise functions and underlying molecular mechanisms of OMA1 in the regulation of mitochondrial homeostasis for CSCs remain unknown.Methods:High-throughput sequencing and bioinformatics were used to select the target molecule, OMA1, and the expression and prognostic significance of OMA1 were analyzed in patients with glioma using data from The Cancer Genome Atlas. The role of OMA1 in regulating mitophagy in gliomas was evaluatedin vitroandin vivo. OMA1 expression in clinical glioma specimens was evaluated using western blotting and immunohistochemistry.Results:Glioma stem cells had higher OMA1 expression and distinct mitochondrial morphology than differentiated tumor cells. OMA1 mediated mitochondrial fission, induced mitophagy in tumor cells, and promoted glioma stem cell stemness maintenance via mitophagy. Interestingly, glioma stem cells displayed a unique oxidative phosphorylation dependence. OMA1 promoted tumor progression in glioma cellsin vitroandin vivo. Mechanistically, OMA1 promoted mitophagy and maintained Pink1 stability through the Pink1/Parkin signaling pathway. Finally, OMA1 promoted tumor immune escape by upregulating PD-L1 expression.Conclusion:OMA1 promotes phenotype maintenance of glioma stem cells by regulating oxidative phosphorylation homeostasis through the Pink1-Parkin-ROS axis. Overall, OMA1 may be beneficial as a therapeutic strategy for gliomas.
Taxonogenomics of Culturomica massiliensis gen. nov., sp. nov., and Emergencia timonensis gen. nov., sp. nov.: two new bacterial species isolated from human stool microbiota
Authors: HAMAME Afaf , WASFY Reham MAGDY , LO Cheikh Ibrahima , FENOLLAR Florence , RAOULT Didier , FOURNIER Pierre-Edouard , HOUHAMDI Linda 
Published: October 2022

Abstract
Two new bacterial strains, Marseille-P2698 (= CSUR P2698 = DSM 103121) and Marseille-P2260 (CSUR P2260 = DSM 101844 = SN18), were isolated from human stools by the culturomic method. We used the taxonogenomic approach, to fully describe these two new bacterial strains. The Marseille-P2698 strain was a Gram-negative, motile, non-spore-forming, rod-shaped bacterium. The Marseille-P2260 strain was a Gram-positive, motile, spore-forming rod-shaped bacterium. Major fatty acids found in Marseille-P2698 were C15:0 iso (63%), C15:0 anteiso (11%), and C17:0 3-OH iso (8%). Those found in Marseille-P2260 strain were C16:00 (39%), C18:1n9 (16%) and C18:1n7 (14%). Strains Marseille-P2698 and Marseille-P2260 had 16S rRNA gene sequence similarities of 91.50% with Odoribacter laneus, and of 90.98% and 95.07% with Odoribacter splanchnicus and Eubacterium sulci, respectively. The exhibited digital DNA-DNA Hybridization values lower than 20.7%, and Orthologous Average Nucleotide Identity values lower than 73% compared to their closest related bacterial species O. splanchnicus and E. sulci respectively. Phenotypic, biochemical, phylogenetic, and genomic results obtained by comparative analyses provided sufficient evidence that both of the two studied strains Marseille-P2698 and Marseille-P2260 are new bacterial species for which the names Culturomica massiliensis gen. nov., sp. nov., and Emergencia timonensis gen. nov., sp. nov. were proposed, respectively.
Extended circle criterion for determination of gain and phase margins of Lur’e systems
Authors: Delavar Abolfazl , Haeri Mohammad 
Published: October 2022

Abstract
The main goal of the present work is proposing a new approach to determine stability margins for a class of nonlinear systems. In particular, we propose a new approach to find the gain and phase margins of Lur’e type nonlinear systems with higher accuracy. To do so, we use multi-section extended circle criterion which is based on Lyapunov stability theorem. To find more precise values of the stability margins, an optimization problem is defined and solved using a nonlinear estimator. Two examples are provided to evaluate the effectiveness of the proposed approach and compare the results to those of the existing methods.
Simultaneous inversion for source field and mantle electrical conductivity using the Variable Projection approach
Authors: Min Jingtao , Grayver Alexander 
Published: October 2022

Abstract
Time-varying electromagnetic field observed on the ground or at a spacecraft consists of contributions from (i) electric source currents, such as those in the ionosphere and magnetosphere, and (ii) corresponding fields induced by source currents within the conductive Earth's interior by virtue of electromagnetic induction. Knowledge about the spatio-temporal structure of inducing currents is a key component in ionospheric and magnetospheric studies, and is also needed in space weather hazard evaluation, whereas the induced currents depend on the Earth's subsurface electrical conductivity distribution and allow us to probe this physical property. In this study, we present an approach that reconstructs the inducing source and subsurface conductivity structures simultaneously, preserving consistency between the two models by exploiting the inherent physical link. To achieve this, we formulate the underlying inverse problem as a separable nonlinear least squares (SNLS) problem, where inducing current and subsurface conductivity parameters enter as linear and non-linear model unknowns, respectively. We solve the SNLS problem by using the Variable Projection method and compare it with other conventional approaches. We study the properties of the method and demonstrate its feasibility by simultaneously reconstructing the ionospheric and magnetospheric currents along with a 1-D average mantle conductivity distribution from the ground magnetic observatory data.
The spatial structure evolution of the urban agglomeration on the Northern Slope of the Tianshan Mountains in Xinjiang, China
Authors: Li Dongbing , Simayi Zibibula , Yang Shengtian , Chang Yao , MAMITIMIN Yusuyunjiang 
Published: October 2022

AbstractIn the process of urbanization, the coordinated development of urban sub-clusters is an important strategy for the overall promotion of the regional economy, and exploring the characteristics of urban spatial structure has reference significance for the transformation of regional levels. This paper selects the land use data and urban statistical data in the study area, and uses the topsis method to evaluate the comprehensive quality of each city. Based on the gravitational model, social network analysis, urban expansion method and correlation analysis method, the basic characteristics of urban spatial structure of the urban agglomeration on the northern slope of Tianshan Mountains are analyzed from macro and micro perspectives, and the spatial pattern of urban network is constructed according to reasonable methods. The results show that: (1) The urban system headed by Urumqi is gradually expanding, and the urban volume is becoming larger. (2) The urban network structure diverges from Urumqi to the periphery, and is most closely connected with the surrounding cities. Urumqi's city center has the highest degree, occupies a dominant position in the city, and has high resource control rights, which can affect the development of the entire region. (3) According to the characteristics of agglomerated subgroups, the urban agglomerations are mainly distributed in three types of subgroups, and the spatial differences in the comprehensive quality of cities in the entire region are obvious. (4) The delineation of urban network structure circles is conducive to further promoting regional Internal coordinated development, and promote the construction of a reasonable urban spatial layout.
The role of women’s empowerments on reproductive healthcare-seeking behavior in Mali
Authors: SIDIBE Yaya , TRAORE Daouda Moussa , BERTHE Bakary , SISSOKO Mamady 
Published: October 2022

Abstract

Background:In Mali, contraception and low utilization of health facilities is a public health problem; it is one of the major causes of morbidity and mortality among children. The maternal mortality rate in Mali is 562 per 100,000 live births, compared to an average of 534 in sub-Saharan Africa.Objective: This article analyses the importance of women empowerment in the reproductive healthcare seeking behavior in Mali.Methods:The methodology used logistic regression based on data from the 2018 Malian Demographic and Health Survey. The principal compenent analysis method was used to construct a multidimensional empowerment index.Results: The results show that women's empowerment is strongly associated with the use of health services and the use of modern contraception, after controlling for sociodemographic factors. In the multivariate model, the lack of association between women's household decision making and health service use and between labor force participation and modern contraceptive use. Conclusion:Women's participation in decision making, within the household, women's activity, area of residence, education level of the household head, and maternal health insurance are factors that, if improved, could significantly reduce reproductive healthcare-seeking behavior. The results suggest that efforts should be made to improve women's autonomy in Mali, to achieve both gender equality and wider use of health care. In addition, improving women's education can play a role in empowering women and increasing their health care-seeking behavior.
Quality of Drinking Water in Selected Coastal Communities of Ondo South Nigeria
Authors: Adeyemo Adeyemi Isaiah , Akintimehin Emmanuel Sina , Adeoye Emmanuel Tayo 
Published: October 2022

AbstractOne hundred drinking water samples were collected from ten selected oil polluted riverine communities of Ondo south Nigeria to investigate their quality. Physicochemical parameters using standard methods reveals values of temperature, electrical conductivity, total hardness, total dissolved solid, turbidity, pH and Dissolved oxygen beyond WHO safe limits while chloride and total alkalinity values fell within the limits. All the heavy metals investigated using Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP – OES) have higher concentrations than permissible by WHO standards. Most Probable Number technique (MPN) confirmed eighty- six of the water samples to have coliforms with thirty- two of them as faecal coliforms while Gram staining and the IMViC tests confirmed seventy of the samples to haveE.coli. Total petroleum hydrocarbon (TPH) was analyzed using Agilent 7890B Gas chromatograph equipped with a flame ionization detector (FID), fitted with a HP-5 capillary column coated with 5% Phenyl Methyl Siloxane and a mean value of 62.164mg/L was obtained for (TPH). Leaching of metals from rocks, oil spillages, and acid rain associated with gas flaring are possibly responsible for the values of physicochemical parameters and toxic metals recorded while the presence of faecal coliforms andE.colimay be due to poor sanitary systems in the area while the TPH is from various oil spills rampant in the area. Improved waste disposal methods, prevention of oil spillages and proper treatment of effluents from industries should be adopted to improve the potability of water in the study area.
Simultaneous 18F-FDG PET/MR metabolic and structural changes in visual snow syndrome and diagnostic use
Authors: Laere Koen Van , Ceccarini Jenny , Gebruers Juanito , Goffin Karolien , Boon Elizabet 
Published: October 2022

Abstract
Purpose

Visual snow syndrome (VSS) is a recently recognized chronic neurologic condition characterized by the constant perceiving of tiny flickering dots throughout the entire visual field. Metabolic overactivity and grey matter volume increase in the lingual gyrus has been reported. We investigated this by 18F-FDG PET/MR in comparison to healthy controls. Aside from voxel-based characterization, the classification accuracy of volume-of-interest (VOI) based multimodal assessment was evaluated, also in comparison with visual analysis.

Methods

Simultaneous 18F-FDG PET and MR imaging was performed in 7 patients with VSS (24.6 ± 5.7 yrs; 5M/2F) and 15 age-matched healthy controls (CON) (28.0 ± 5.3 yrs; 8M/7F). SPM12 and voxel-based morphometric (VBM) analysis was performed. A VOI-based discriminant analysis was performed with relative 18F-FDG uptake, MR grey matter (GM) volumes and their combination. A visual analysis was done by two blinded experienced readers.

Results

Relative increased hypermetabolism was found in VSS patients in the lingual gyrus and cuneus (pFWE<0.05, peak change + 24%), and hypometabolism in the mesiotemporal cortex (pheight,uncorr<0.001, peak change − 14%). VSS patients also had increased GM volume in the limbic system and frontotemporal cortex bilaterally (pFWE<0.05), and in the left secondary and associative visual cortex and in the left lingual gyrus (pheight,uncorr <0.001). Discriminant analysis resulted in 100% correct classification accuracy for 18F-FDG with lingual gyrus, cuneus and lateral occipital lobe (BA 17 and BA 18) as main discriminators. Unimodal MR- and combined 18F-FDG + MR classification resulted in an accuracy of 91% and 95%, respectively. Visual analysis of 18F-FDG was highly observer dependent.

Conclusion

Patients with VSS have highly significant structural and metabolic abnormalities in the visual and limbic system. VOI-based discriminant analysis of 18F-FDG PET allows reliable individual classification versus controls, whereas visual analysis of experienced observers was highly variable. Further investigation in larger series, also in comparison to VSS mimicking disorders such as migraine, is warranted.
Retrospectively registered at clinicaltrials.gov under NCT05569733 on Oct 5, 2022.
Real-time estimate and control contour errors for five-axis local smoothed toolpaths based on airthoid splines
Authors: Huang Xiaoyong , Chen Baoqing , Tian Xiaoqing , Chen Shan , Yu Daoyang , Han Jiang , Mei Xuesong 
Published: October 2022

Abstract

Five-axis linear commands are blended as the local smoothed toolpaths by inserting clothoid and airthoid splines at corners in five-axis CNC machining. The contour error is the bottleneck to achieve the precise dimension of the machined parts, when following the smoothed toolpaths. This paper presents a contour error estimation and control method for the five-axis smoothed toolpaths with airthoid splines, according to the geometric characteristics of the toolpaths. The tool-tip contour error is analytically calculated based on the expression of the smoothed toolpaths. Consequently, the tool-orientation contour error is obtained by synchronizing the tool-orientation contour point with the tool-tip item based on the motion time through the designed time scale coefficient, when the toolpaths are scheduled by the time-synchronization scheme. Furthermore, a contour error compensation strategy is constructed to adaptively determine the compensator gain. It can be qualified to maximally eliminate the contour errors and steadily hold the control stability of the feed drives, in spite of the modeling error between the nominal and actual control models. The simulation and experiment results show that the estimation algorithm has the higher accuracy than traditional methods, and the compensation strategy effectively eliminates the five-axis contour error.
Downstream allosteric modulation of NMDA receptors by 3-benzazepine derivatives
Authors: Ritter Nadine , Disse Paul , Aymanns Isabel , Mücher Lena , Schreiber Julian Alexander , Brenker Christoph , Strünker Timo , Schepmann Dirk , Budde Thomas , Strutz-Seebohm Nathalie , Ametamey Simon Mensah , Wünsch Bernhard , Seebohm Guiscard 
Published: October 2022

Abstract
N-methyl-D-aspartate receptors (NMDARs) composed of different splice variants display distinct pH sensitivities and are crucial for learning and memory, as well as for inflammatory or injury processes. Dysregulation of the NMDAR is associated with diseases like Alzheimer’s, Huntington’s, depression and substance addiction. The development of selective receptor modulators therefore constitutes a promising approach for multiple therapeutical applications. Here, we identified (R)- OF-NB1 as a promising splice variant selective NMDAR antagonist. We investigated the interaction of ( R )-OF-NB1 and NMDAR from a biochemical, bioinformatical and electrophysiological perspective to characterize the downstream allosteric modulation of NMDAR by 3-benzazepine derivatives. The allosteric modulatory pathway starts at the ifenprodil binding pocket in the amino terminal domain and immobilizes the connecting α5-helix to the ligand binding domain, resulting in inhibition. On the contrary, the exon 5 splice variant GluN1-1b elevates the NMDARs flexibility and promotes the open state of the of its ligand binding domain.
Application of a Novel Method for Predicting Water Quality Using the Pi-Sigma Neural Network: Gelevera Creek (Giresun, Türkiye)
Authors: Isık Hakan , Akkan Tamer 
Published: October 2022

Abstract
Identifying and measuring potential sources of pollution is essential for water management and pollution control. Using a range of artificial intelligence models to analyze water quality (WQ) is one of the most effective techniques for estimating WQI. In this context, water samples have been collected in monthly from 8 stations of Gelevera Creek. The traditional evaluation with WQI of Gelevera Creek was calculated as average so good WQ. The novel application which is the Single multiplicative neuron (SMN) model, multilayer perceptron and pi-sigma artificial neural networks (PS-ANNs) are applied for predicting of WQI. SMN model and PS-ANNs are firstly used for modelling of WQ in the literature. It is noted that the best results of Gelevera Creek were obtained with the PS-ANN. As a result of, it is suggested to obtain the WQI with the proposed optimum PS-ANN instead of using calculation methods such as WQI that include long calculations.