bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANÁLISE DA INFLUÊNCIA DA COVID- 19 EM PARTOS PREMATUROS: REVISÃO INTEGRATIVA
Authors: Meira Nobrega Dos Santos Gomes Gabriela , Ferreira Ingrid Jornada Bernardes , Alves Da Silva Santos Anna Izabel 
Published: September 2022

Em 11 de fevereiro de 2020 a Organização Mundial de Saúde (OMS) denominou uma nova doença, Coronavírus 19 (COVID-19) e sendo declarada a pandemia em março de 2021. A COVID-19 é causada por Coronavírus 2 de Síndrome Respiratória Aguda Grave (SARS- CoV-2). Gestantes foram suscetíveis a desenvolver um quadro clínico mais grave. A COVID-19 se relaciona a desfechos maternos e fetais adversos, incluindo admissão na Unidade de Terapia Intensiva (UTI), cesariana, sofrimento fetal e parto prematuro. Esta revisão integrativa teve como objetivo identificar os fatores que contribuem para que gestantes com COVID-19 evoluam para parto prematuro. Foram seguidos os critérios propostos pelo Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), a partir de publicações cientificas encontradas nas bases de dados Science Direct, PubMed e Biblioteca Virtual em Saúde (BVS/MEDLINE), direcionada com o auxílio dos descritores “preterm birth”, “premature birth labor”, “pregnancy” e “coronavirus infection”, verificados no Descritores em Ciências da Saúde. Foram eleitos os seguintes critérios de inclusão: responder à pergunta principal, artigos publicados entre os anos de 2019 e 2021 e nos idiomas inglês e português. Como resultados o estudo contou com uma amostra de 10 artigos que preencheram os critérios de inclusão, sendo que os estudos deveriam apresentar fatores de risco que influenciassem a progressão do parto prematuro em gestantes infectadas por COVID-19. Conclui-se, portanto, que um conjunto de fatores podem desencadear o parto prematuro, como a infecção por SARS-CoV-2 no terceiro trimestre da gestação, comorbidades, a coinfecção bacteriana, hipoxemia placentária, coagulopatias, transtornos mentais e iatrogênia. No entanto, é necessário estudos com uma população maior para homogeneizar os resultados.
Long Non-coding RNA DLGAP1-AS1 and DLGAP1-AS2: Two Novel
Oncogenes in Multiple Cancers
Authors: Zhao Fangnan , Tan Fangshun , Tang Lu , Du Zhuoying , Chen Xiaoya , Yang Yuzhi , Zhou Gang , Yuan Chengfu 
Published: September 2022

Background:
The change of lncRNA expression is known to affect the progression
of tumors. This has fueled numerous investigations aiming at the mystery of lncRNA.
Clear lncRNA has been the hotspot of antisense RNAs research. More and more
lncRNAs have been proven to take effect as oncogenes of multitudinous cancers and accelerate
tumor progression. This review elucidates the pathophysiological functions of lncRNA
DLGAP1-AS1 and lncRNA DLGAP1-AS2 in a variety of tumors.

Methods:
Via systematic analysis and in-depth study about relevant articles in PubMed,
this article analyzes and summarizes the mechanism of antisense transcripts DLGAP1-
AS1 and DLGAP1-AS2 in tumor development.

Results:
DLGAP1-AS1 and DLGAP1-AS2 can exert their effect as oncogenes on various
cancers. The expression of DLGAP1-AS1 is aberrantly high in various tumors, including
GC, BC, HCC, glioblastoma and CRC. Concurrently, in LC, RC, HCC, GC, glioma
and CCA, DLGAP1-AS2 is also discovered to be highly expressed. And they have a
strong pertinence with a poor prognosis. The disorder of DLGAP1-AS1 and DLGAP1-
AS2 in different tumors has different malignant impacts on tumors, not only to invasion,
apoptosis, multiplication and EMT of tumor cells but also to drug resistance and
radioresistance. In addition, DLGAP1-AS2 was revealed to have the ability to predict the
prognosis of WT and RCC.

Conclusion:
The regulatory effects of DLGAP1-AS1 and DLGAP1-AS2 on tumors
make them possible to be clinical markers for the early diagnosis of tumors and effective
therapeutic targets.
Trimethylamine N-Oxide Generated by the Gut Microbiota: Potential Atherosclerosis
Treatment Strategies
Authors: Zhu Botao , Ren Hao , Xie Feng , An Yuze , Wang Yichuan , Tan Yurong 
Published: September 2022

Abstract:
Cardiovascular diseases (CVD) have become a disease burden that plagues the world, and a large
proportion of the world's mortality currently stems from atherosclerotic CVD. In addition to traditional therapies, we need to find more therapeutic targets and strategies in scientific research to address this challenge. In
recent years, as research on gut microbiota has continued, there has been a clearer understanding of the role that
metabolites from gut microbes play during atherosclerosis (AS). A growing body of research suggests that
trimethylamine oxide (TMAO) is an independent risk factor for CVD and that gut microbe-dependent TMAO
plays a critical role in AS. Therefore, interventions targeting TMAO have the potential to become a new therapeutic strategy for AS. This review provides a brief overview of the relationship between TMAO and atherosclerosis. More importantly, several potential atherosclerosis treatment strategies targeting TMAO and its metabolic pathways have been revealed by recent studies and will be the focus of this review. This review summarizes possible therapeutic strategies in terms of change of diet, adjustment of gut microbiota, suppression of liver enzyme activity, and improvement of renal function, in the hope of providing new insights for developing
efficient and cost-effective treatment and prevention for AS.
Neurological Complications of SARS-CoV-2 Infection and COVID-19
Vaccines: From Molecular Mechanisms to Clinical Manifestations
Authors: Yepes Manuel 
Published: September 2022

Abstract:
Coronavirus Disease 2019 (COVID-19) is an infectious disease, caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), that reached pandemic proportions in 2020. Despite the fact that it was initially characterized by pneumonia and acute respiratory distress syndrome, it is now clear that the nervous system is also compromised in one third of these patients. Indeed, a significant proportion of COVID-19 patients suffer nervous system damage via a plethora of mechanisms including hypoxia, coagulopathy, immune response to the virus, and the direct effect of SARS-CoV-2 on endothelial cells, neurons, astrocytes, pericytes and microglia. Additionally, a low number of previously healthy individuals develop a variety of neurological complications after receiving COVID-19 vaccines and a large proportion of COVID-19 survivors experience long-lasting neuropsychiatric symptoms. In conclusion, COVID-19 is also a neurological disease, and the direct and indirect effects of the virus on the nervous system have a significant impact on the mor-bidity and mortality of these patients. Here we will use the concept of the neurovascular unit, as-sembled by endothelial cells, basement membrane, perivascular astrocytes, neurons and microglia, to review the effects of SARS-CoV-2 in the nervous system. We will then use this information to review data published to this date on the neurological manifestations of COVID-19, the post-COVID syndrome and COVID-19 vaccines.
A Network Pharmacology Guided Mechanism of Action Study on Oldenlandia
diffusa Against Osteosarcoma
Authors: Zhao Jun , Dong Liang , Wang Jun , Pan Boyu , Yang Yun 
Published: September 2022

Background:
Osteosarcoma (OS) is the most prevalent primary bone sarcoma in the global
child and young adult population, and the current mainstream treatment regimens are not very effective.
The unique efficacy of traditional Chinese medicine (TCM) for cancers has recently received increasing
attention. Oldenlandia diffusa (OD) is commonly used as adjuvant therapy for various cancers in Chinese
herb medicine (CHM) with its unique pharmacological activities, but its therapeutic effect as well as the
underlying mechanism against OS has yet to be systematically investigated.

Objective:
This study aims to find the underlying active mechanism of OD against OS.

Methods:
The candidate ingredients as well as drug targets of OD were obtained from the Traditional
Chinese Medicine System Pharmacology (TCMSP) database, respectively. Meanwhile, the OS diseaserelated
targets were acquired from GeneCards and MalaCards online databases. Then, by using Venny
2.1, the common key targets were imported into the STRING database to acquire their interaction relationship,
and imported this PPI network file (.csv) into Cytoscape 3.6.0 software and merged to obtain
PPI network intersections. Meanwhile, the MCODE plugin of Cytoscape was also used to further trim the
core therapeutic targets. GO and KEGG enrichment and molecular docking analyses were performed to
predict the underlying mechanism of OD against OS. Furthermore, in silico analysis results were validated
by a series of cellular functional and molecular biological assays.

Results:
A total of 131 putative targets were identified to be involved in the anti-OS activity of OD. The
PPI network, GO as well as KEGG analyses revealed that the 18 core targets were closely related to cell
proliferation, apoptosis. Importantly, the subsequent in vitro assays verified that the suppressive effect of
OD on OS cell growth indeed resulted from disrupted apoptosis and cell proliferation via Akt and ERK
signaling pathways. Furthermore, our results showed that quercetin, beta-sitosterol and 2-methoxy-3-
methyl-9,10-anthraquinone were the key ingredients, while PTGS2, CASP3 and JUN were the key targets
in delivering the pharmacological activities of OD against OS, thus providing an insight into the anti-OS
action of OD from a holistic perspective.

Conclusion:
In summary, our results indicate that OD has good prospects in the treatment of OS.
Déficit de Vitamina B12 en consumo de Metformina e Inhibidores de Bomba de Protones
Authors: Frías Ordoñez Juan Sebastián , Arjona Granados Dayana Andrea , Martínez Marín Julián David 
Published: September 2022

El espectro de enfermedades asociadas con la deficiencia de la vitamina B 12 es amplio y abarca desde la ausencia de síntomas hasta el síndrome de malabsorción, insuficiencia medular, o síntomas neurológicos acompañados de parestesias, mielopatía o neuropatía. Existe evidencia sugestiva que indica que el empleo de inhibidores de bomba de protones (IBP) a largo plazo puede disminuir los niveles séricos de vitamina B12. Igualmente, estudios previos han asociado el déficit de vitamina B 12 a consumo en dosis altas de metformina, sin embargo, el mecanismo por el cual se genera la descompensación no está claro. Se ha llegado a describir una asociación aditiva de la administración de inhibidores bomba de protones/ Antagonistas receptor Histamina - 2 y metformina, sugiriendo que promueven la malabsorción de Vitamina B 12. Ambas categorías de medicamentos son ampliamente utilizadas, y en muchos casos sin prescripción médica, y su uso no debería ser pasado por alto. Cuando están clínicamente indicados, su uso debería ser monitorizado debido a la posibilidad de malabsorción de vitamina B 12 y sus consecuencias. Por tanto, en este artículo se revisan aspectos generales sobre la vitamina B12 y el estado del arte sobre la deficiencia de vitamina B12 en pacientes con consumo de metformina o uso de inhibidor de bomba de protones.
Factores biosociales asociados a la mortalidad materna en el departamento de Chocó 2013-2019
Authors: Mosquera Córdoba Miladys , Cuesta Caicedo Angela Patricia 
Published: September 2022

Objetivo: Describir la convergencia de fuerzas biosociales que interactúan para producir y exacerbar la mortalidad materna en el departamento de Chocó.
Materiales y métodos: Estudio descriptivo, retrospectivo de la mortalidad materna y los factores asociados en el Chocó. Se solicitó autorización para revisión de fichas de vigilancia epidemiológica de todos los casos de muertes maternas entre 2013 y 2019. Se garantizó la confidencialidad usando códigos y número de historia clínica, para identificación. Además, se revisó la Encuesta Nacional de Demografía y Salud ENDS 2015 y los informes de control prenatal en el departamento del Chocó para identificar factores asociados a la mortalidad materna.
Resultados: Se registró un total de 96 muertes maternas durante el período 2013-2019. El grupo comprendido entre 30-34 años de edad aportó el mayor número de casos de muerte materna (17 muertes). El 90% de los fallecimientos maternos pertenecían al Sistema General de Seguridad Social, 10% correspondía a población pobre no asegurada. El 94% (68) de los fallecimientos obstétricos corresponde a mujeres que desempeñaban labores en el hogar y 6% (4) empleadas del sector público. La principal causa de mortalidad materna se relacionó con trastornos hipertensivos en el embarazo. Se evidenció que solo el 72% de las gestantes recibieron control prenatal por médico en Chocó y el 6.6% de los controles fue realizado por enfermeras. En 2020, se reportó que el porcentaje máximo de nacidos vivos con más de 4 consultas de control prenatal fue 79.49%.

Conclusiones: La situación observada sugiere la implementación de estrategias que mejoren el acceso a servicios de salud integrales de calidad. Se debe garantizar una articulación entre las autoridades de salud, actores de prestación de servicios del sistema de salud, actores comunitarios locales y la academia.
Fibromatosis de Colli
Authors: Holguín  Barrera Mónica Liseth , Medina Barrera Sharon Brigitte , García Agudelo Lorena , Camargo Tarache Cynthia Catalina 
Published: September 2022

Introducción: La Fibromatosis Colli es un tumor fibroso congénito benigno que se desarrolla en el músculo esternocleidomastoideo. Se manifiesta clínicamente por hinchazón del cuello y restricción de movimiento del cuello (tortícolis).
Objetivo: Describir los aspectos diagnósticos y terapéuticos fundamentales de la Fibromatosis de Colli o Tortícolis Muscular Congénita.
Caso Clínico: Se presenta un caso de neonato de sexo femenino de 21 días de nacida mediante parto en presentación podálica. Al examen físico se encuentra masa en cuello de 1,5*2 cm indolora e inclinación de la cabeza hacia la derecha, diagnosticado con ultrasonografía y tomografía de cuello contrastado, sin otros hallazgos.
Conclusiones: La Fibromatosis de Colli es una patología que pasa desapercibida en el examen posparto del recién nacido. Es importante que el personal médico la identifique, evitando así complicaciones futuras, como asimetría craneofacial, escoliosis cervical y torácica o alteraciones oculares importantes.
Safety and efficacy of Ketamine in a patient with psychotic depression, cardiovascular disease, and starvation risk
Authors: Trejos Orozco Efraín Alberto , Gutiérrez Segura Julio César , Ochoa Orozco Sergio Andrés 
Published: September 2022

Introduction: There has been a rising interest in ketamine as a promising treatment for refractory depression. Despite this, there is uncertain knowledge regarding aspects of the routinary use of ketamine for treating depression, such as optimal doses, long term toxicity, abuse potential in depressed patients, probable adverse effects associated with antidepressant drugs, the indication of ketamine in psychotic patients, and the ethical concerns of ketamine use.
Clinical case: A 63 year-old woman with a psychotic depressive episode, catatonic features, cardiovascular disease (patent foramen ovale and atrial fibrillation) , and starvation risk because she refused food intake. She was sent to electroconvulsive therapy (ECT) after several weeks of oral administration of benzodiazepine, antipsychotic, and antidepressant medications; the patient presented no improvement, but she was rejected due to her cardiovascular comorbidity. Two IV Ketamine doses were used as a life-saving strategy with good clinical response, mainly in terms of the catatonic features. The ketamine treatment was not only effective but also well tolerated.
Discussion: Despite the little information regarding its use in psychotic and catatonic patients, this case would suggest that it remains effective and safe, as well as a good option for patients with cardiovascular disease and those who cannot use electroconvulsive therapy.
At-home Bleaching with a Novel Carbamide Peroxide Polymeric Nanoparticle Gel: A Multicenter Randomized Controlled Trial
Authors: Favoreto MW , Hass V , Maran BM , de Paula E , Wachter F , Lima SNL , de Jesus Tavarez RR , Reis A , Loguercio AD 
Published: September 2022

SUMMARY

Objectives
To compare the risk and intensity of tooth sensitivity (TS) as well the effectiveness of at-home bleaching using two carbamide peroxide bleaching gels, specifically a novel polymeric nanoparticle gel (experimental) and a commercial gel (Opalescence PF, Ultradent, South Jordan, Utah, USA), applied at two application times.

Methods
This multicenter, triple-blind, and split-mouth randomized controlled trial was conducted on 80 healthy adults with canine teeth that were shade A2 or darker. The participants all used the experimental and the control gels on one side of a tray, depending on the group to which they were allocated, for 30 or 60 minutes per day over four weeks. The absolute risk and intensity of TS were assessed daily using the five-point Numeric Rating Scale and the 0–10 Visual Analogue Scale. Color change was evaluated with shade guide units (ΔSGU) and a digital spectrophotometer (ΔEab, ΔE00, and ΔWid) at baseline and 30 days postbleaching. The risk and intensity of TS was evaluated by the McNemar and the Wilcoxon signed-rank tests, respectively. Color change (ΔSGU, ΔEab, ΔE00, and ΔWid) was evaluated by Mann–Whitney and paired t-tests (α=0.05).

Results
No differences in the risk and intensity of TS were observed based on the bleaching gels used and the times of application (p&gt;0.05). Thirty days after bleaching, there was no significant difference in color change, in terms of the bleaching gels used or the application times (p&gt;0.05).

Conclusion
The novel carbamide peroxide polymeric nanoparticles gel, when applied for 30 or 60 minutes, produced effective color change and a low rate of tooth sensitivity, as compared to the control group.
ANALYSIS OF FACTORS DETERMINING THE LEVEL OF JOB SATISFACTION OF PRIVATE COLLEGE LECTURERS IN BANJARMASIN
Authors: Zagladi Arief Noviarakhman 
Published: September 2022

ABSTRACT
Job satisfaction is a factor that really needs to be considered in various work organizations, including educational organizations, because job satisfaction has been shown to have many influences on various organizational outputs, especially on work performance. This study aims to determine the level of job satisfaction of private college lecturers and which factors have the greatest role in shaping lecturers’ job satisfaction in Banjarmasin City, South Kalimantan. Respondents in this study were 314 permanent lecturers in various private college that still active in Banjarmasin City. Job satisfaction was measured by 5 indicators, each described by a few items. Data analysed using Spearman’s Correlation to determine the correlation between every indicator to it’s total variable. The results of the study found that the most satisfying factor according to the lecturers was the work environment, while the factor that had the biggest role in shaping job satisfaction was workplace guidance, especially the role of leadership in directing and providing input to lecturers. It is hoped that through this research, lecturers' job satisfaction can be maintained and have a positive impact on various other organizational outputs.
Método didáctico “Socioneuropsicológico” y la estimulación de la integración hemisférica cerebral, en educandos del nivel primario.
Authors: Ayay Arista Guido 
Published: September 2022

RESUMEN:La investigación, tuvo por objetivo sistematizar el método didáctico “Socioneuropsicológico”, en un cuerpo teórico conceptual, centrado principalmente en procedimientos que estimulen la predominancia en la integración hemisférica cerebral, derecha-izquierda, sobre la base de las teorías derivadas de la neurociencia y las ciencias de la educación. Se ha empleado el diseño de investigación denominado “diseño de grupos aleatorizados pre y post test”. La muestra, estuvo conformada por educandos de dos secciones del sexto grado de la Institución Educativa “San Juan de la Libertad” - Chachapoyas, una de 17 educandos para el grupo experimental y otra de 15 para el grupo control. Las hipótesis contrastadas mediante el parámetro estadístico T-Student, revelan que la experimentación del método didáctico “Socioneuropsicológico”, evidencia estimulación significativa de la predominancia en la integración hemisférica cerebral, derecha-izquierda como resultados cuali-cuantitativos. Por consiguiente, se concluye, que la sistematización del método, estimula la integración hemisférica cerebral, de doce funciones bipolares. En el hemisferio cerebral izquierdo se estimulan la función verbal, analítica, simbólica, matemática, de abstracción, lógico-racional, temporal, audiovisual, intelectual, específica, de convergencia y de interpretación. En el hemisferio cerebral derecho se estimulan las funciones no verbal, sintética, espacial, artística, de concreción, emocional, atemporal, cinestésica, sensual, sistémica, de divergencia y creatividad.Palabras clave: Método didáctico, estimulación, neurociencias, predominancia, integración hemisférica, hemisferios cerebrales.
The Mental Health Education Management of Higher Vocational Students Based on Fractional Differential Equations
Authors: Zeng Ting 
Published: September 2022

Abstract
Based on fractional differential equations, this paper proposes an optimization modeling method for the mental health quality of vocational students. This article quantifies the psychology of higher vocational students from the perspective of fractional differential equations. At the same time, we use alertness to characterize the risk of mental fatigue and propose a mental health energy equation. We propose a mental health energy replenishment function and consumption function and describe mental health energy during sleep. Finally, we use fractional differential equations to reason about the model deductively. The research shows that it is feasible for us to apply fractional differential equations to predict the mental health problems of vocational students.
Statistical Model of College Ideological and Political Learning Based on Fractional Differential Equations
Authors: Liu Songrui , Li Jinzhu , Khalifa Mahmoud 
Published: September 2022

Abstract
Based on fractional differential equations, this paper focuses on the internal mechanism of college ideological and political learning. We also elaborate on its microstructure, channel characteristics, and competitive field. We put forward Gauss’s theorem and the loop theorem of the related field of ideological and political learning in colleges and universities. At the same time, the convexity theorem of the information entropy of the competitive field and the principle of maximum entropy are proved. Research shows that college students can change the relationship between student learning and society by adapting, functioning, and coordinating. We need to help students develop more effective political learning strategies.