bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of Alzheimer’s disease in patients with the syndrome of mild cognitive impairment, amnestic type (cluster analysis)
Authors: Simonov A. , Klyushnik T. , Androsova L. , Mikhaylova N. , Kolykhalov I. 
Published: September 2022

IntroductionThe creation of mathematical models for determining the risk of Alzheimer’s disease in patients with mild cognitive impairment based on immune markers of blood is important for differential diagnosis of AD, assessment of the clinical state of patients at different stages of the disease, and optimization of therapy.ObjectivesTo assess the risk of AD in patients with amnestic type of mild cognitive impairment (aMCI) with the use of such markers of inflammation as enzymatic activity of leukocyte elastase (LE) and the functional activity of α1-proteinase inhibitor (α1-PI).MethodsThe object of mathematical analysis on the basis of cluster analysis and logistic regression was the database, including the results of the above immunological parameters (enzyme activity of LE and functional activity of α1-PI.) in plasma of 78 patients with aMCI receiving outpatient treatment in the clinic of FSBSI “Mental Health Research Centre”. Among the examined patients there were 25 men and 53 women aged 44 to 89 years (69.1 ± 9.95).ResultsClustering by k-means and classification by logistic regression indicate the risk of developing AD in patients with aMCI depending on the activity of LE and α1-PI in blood plasma. The total coincidence of objects included in the clusters and in the AD risk group was 94%.ConclusionsThe high coincidence of the two different methods of grouping confirms the previously stated position on the possibility of identifying patients with a high risk of AD among patients with aMCI in the activity of LE and α1-PI in the blood of patients.DisclosureNo significant relationships.
The role of inflammation and cortisol in the relationship between social cognition abilities and later emotional or behavioural problems: evidence from a UK birth cohort
Authors: Ji D. , Papachristou S. , Francesconi M. 
Published: September 2022

IntroductionDeficits in social cognition have been associated with the onset of emotional and behavioural problems, but the biological mechanisms underlying this relationship remain unclear.ObjectivesThis study examined whether diurnal cortisol patterns, systemic inflammation, or both, explained the association between social cognition difficulties and subsequent emotional and behavioural symptoms.MethodsThe sample consisted of 714 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC) with valid data on cortisol measures (age 15 years) and emotional or behavioural problems (age 17 years). Social cognition abilities were measured at 8, 11, and 14 years old. Inflammation was measured using serum levels of interleukin 6 (IL-6, age 9 years) and C-reactive protein (CRP, age 9 and 16 years). Bayesian structural equation modelling was used to investigate the mediating effect of cortisol or inflammation on the association between social cognitive difficulties and emotional or behavioural problems.ResultsChildren with social cognition difficulties were associated with later emotional and behavioural problems. Flattened diurnal cortisol slope was associated with the hyperactivity/inattention problem two years later. Mediation analyses revealed that lower morning cortisol significantly mediated the associations between social communication difficulties at 8 years with hyperactivity/inattention and conduct problems in adolescence, with the adjustment of inflammation and all covariates. Systemic inflammation was not related to social cognitive difficulties or future emotional and behavioural problems.ConclusionsThe finding suggests that social cognition is related to cortisol activities longitudinally. It also expands the evidence that adolescents with behavioural problems are characterised by hypoactivity of the hypothalamic-pituitary-adrenal (HPA) axis.DisclosureNo significant relationships.
When Parents have a Severe Mental Illness : Can we Prevent Family Separation and Adverse Effects after Childbirth?
Authors: Sutter-Dallay A.-L. 
Published: September 2022

This presentation will review the current state of knowledge about severe maternal perinatal mental illness. Severe disorders are associated with a higher prevalence of somatic difficulties during pregnancy, poorer quality of pregnancy follow-up and potential impairment of infant care. These children are therefore very vulnerable and require specific care. We will present how graduated care coordinated and above all integrated between psychiatry, obstetrics, neonatal pediatrics and child protection services allows for early and effective preventive interventions, both for the child’s development and maternal mental health. The concept of shared parenting will be particularly developed.DisclosureNo significant relationships.
Mental health professionals’ attitudes towards patients with borderline personality disorder: The role of disgust
Authors: Papathanasiou C. , Stylianidis S. 
Published: September 2022

IntroductionMental health professionals’ derogatory attitudes towards patients diagnosed with borderline personality disorder (BPD) may negatively affect treatment outcomes.ObjectivesWe aimed to identify a) negative attitudes exhibited by mental health professionals towards BPD patients and b) the effects of disgust propensity and disgust sensitivity on theses negative attitudes.MethodsMental health professionals (N = 136) completed questionnaires on attitudes towards BPD patients, disgust propensity/sensitivity, and sociodemographic variables.ResultsSignificant differences in negative attitudes toward BPD patients based on gender, marital status, occupational subgroup, educational level, psychotherapy training, level of exposure to BPD patients, and political ideology were found. Results suggested BPD patients are viewed by mental health professionals as ineffective, incomprehensible, dangerous, unworthy, immoral, undesirable to be with, and dissimilar to the mental health professionals. Moreover, disgust propensity and the pathogen component of disgust sensitivity were associated with stronger negative attitudes towards BPD patients.ConclusionsThe findings emphasize the importance of mental health professionals’ awareness of the emotion of disgust as a relevant factor to their negative attitudes towards BPD patients.DisclosureNo significant relationships.
Combining international survey datasets to identify indicators of stress during the COVID-19 pandemic: A machine learning approach to improve generalization
Authors: Adamson M. , Zhao E. , Xia D. , Colicino E. , Monaro M. , Hitching R. , Harris O. , Greenhalgh M. 
Published: September 2022

IntroductionThe magnitude and exceptional opportunity to research the psychological distress of shelter in place resulted in a publication frenzy on a smorgasbord of research studies of variable scientific robustness. Confinement, fear of contagion, social isolation, financial hardship, etc. equated to stratospheric stress levels. The decline in protective factors as a function of quarantine anecdotally reflected historic rates of anxiety and depression.ObjectivesIn this study, we combined 12 variegate datasets and developed an algorithm to build a model to identify key predictors of pandemic-related stress with high accuracy and generalizability.MethodsThis study reports on existing published data. We first describe the International (Adamson et al., 2020) and then the Italian dataset (Flesia et al., 2020). The time-frame (first wave of lockdown), method (survey), measurement tool (Perceived Stress Scale), and outcome measures were extremely similar to enable consolidation of datasets (see Figure1). The Flesia et al., (2020) data set was integrated into the Adamson et al., (2020) dataset as the first step towards data validation construction of the ML predictive model.ResultsWe aim to demonstrate the strength of combining cross-cultural datasets, and the applicability of ML algorithms to facilitate the process and generate a predictive model that identifies and validates key predictors of pandemic-related stress and accommodates for interaction with demographic, cultural, and other mitigating factors while concurrently having high generalizability.ConclusionsWe believe our model provides clinicians, researchers, and decision-makers with evidence to investigate the moderators and mediators of stress, and introduce novel interventions to mitigate the long-term effects of the COVID-19 pandemic.DisclosureNo significant relationships.
Depression and health-related quality of life in critical COVID-19 survivors
Authors: Silva J. , Martins S. , Ferreira A.R. , Fernandes J. , Vieira T. , Fontes L. , Reis N. , Braga A. , Coimbra I. , Paiva J.A. , Fernandes L. 
Published: September 2022

IntroductionLong-term neuropsychiatric consequences of critical illness are well known. Therefore, it is expected that critical COVID-19 patients might also present several psychiatric symptoms such as depression, with inevitable negative effect on health-related quality of life (HRQoL), commonly used as an indicator of illness and treatment impact.ObjectivesTo identify depressive symptoms in critical COVID-19 survivors and to examine its association with HRQoL domains.MethodsThis preliminary study involved critical COVID-19 patients admitted into the Intensive Care Medicine Department (ICMD) of a University Hospital, between October and December of 2020. Patients with an ICMD length of stay (LoS)≤24h, terminal illness, major auditory loss, or inability to communicate at the follow-up time were excluded. From 1-2 months after discharge, all participants were evaluated by telephone at follow-up appointment, with Patient Health Questionnaire (PHQ-9) (depression) and EuroQol 5-dimension 5-level EQ-5D-5L (HRQoL). This study is part of the longitudinal MAPA project.ResultsEighty-three patients were included with a median age of 63 years (range: 31-86) and the majority were male (63%). The most reported problems on EQ-5D-5L domains were usual activities (82%) and mobility (76%). About 27% presented depressive symptoms, and with more problems of self-care (68%vs41%; p=0.029), pain/discomfort (86%vs49%; p=0.002), and anxiety/depression (96%vs54%; p<0.001).ConclusionsThese preliminary results are in line in previous studies in critical COVID-19 survivors, with depression being associated with worse HRQoL. Bearing this in mind, follow-up approaches with an early screening and treatment of these psychiatric symptoms will be fundamental to optimize the recovery of these patients.DisclosureNo significant relationships.
The connection of dysfunctional breathing with Self-Government styles in the Russian population during the COVID-19 pandemic
Authors: Koniukhovskaia J. , Pervichko E. , Mitina O. , Stepanova O. , Petrenko V. , Shishkova I. , Dorokhov E. 
Published: September 2022

IntroductionDysfunctional breathing is experienced as “difficulty in inhaling” and is similar to the symptoms of COVID-19 (Gavriatopoulou et al., 2020), which justifies the relevance of studying this phenomenon in the conditions of the COVID-19 pandemic.ObjectivesTo identifiy a relationship between self-management styles and the severity of dysfunctional breathing in the uninfected COVID-19 population of Russia.MethodsThe author used the socio-demographic questionnaire, the Naimigen Questionnaire (Van Dixhoorn, Duivenvoordent, 1985) and J. Kuhl’s and A. Fuhrman’s Self-Government Test (Kool, Furman, 1998; Kul, Kvirin, Kool, 2020). The study was conducted online from April 27 to December 28, 2020. It was attended by 1,362 people from all regions of Russia (38.3 ±11.4y.o.).ResultsThe components are Self-regulation (r = -0.454, p = 0.000) and Self-Control (r =-0.197, p=0.000). There is also a component of Will Development (r=-0,297, p = 0,000) and Sensitivity to oneself (r=-0,480, p=0,000). It is important to note that dysfunctional breathing has a strong positive correlation with the component of life stress experiencing (=0.335, p=0.000). At the same time, the components of Self-regulation and Self-sensitivity have large correlation coefficients, which indicates their greater role.ConclusionsPeople with low self-regulation and self-control, as well as with less expressed will and sensitivity to themselves, are more likely to have dysfunctional breathing and a more pronounced experience of life stress in a pandemic. The described components can be used as “targets” for individualized psychotherapy of dysfunctional breathing in the conditions of the COVID-19 pandemic. The study was supported of the Russian Science Foundation, project No. 21-18-00624.DisclosureThe study was carried out with the support of the Russian Science Foundation, project No. 21-18-00624.
Emotional state of healthcare workers in hospital red-zone during COVID-19 Pandemic
Authors: Kryzhanovskiy S. , Samushia M. , Berishvili T. , Shmirev V. , Amosova N. 
Published: September 2022

IntroductionThe COVID-19 pandemic has a significant impact on the mental state of not only quarantined citizens and patients, but also health workers.ObjectivesThe aim of the study was to assess of the mental health of doctors involved in work in the “red zone” during the COVID-19 pandemic.Methods77 respondents were interviewed using the HADS questionnaires and the Maslach burnout test. For statistical data processing Microsoft Office Excel 2016, IBM SPSS were used.ResultsAn increase on the depression scales was noted in 7%, anxiety in 23%, and anxiety and depression together 27%. According to the Maslach questionnaire, 32 (41.5%) doctors noted a reaction of the type of “emotional devastation”. 10 (12.9%) doctors noted a reaction “reduction of professional achievements”. Three doctors (3.8%) had a dehumanization reaction in the form of dull emotions to colleagues and patients.ConclusionsWork in the “red zone” has a significant negative impact on the mental health of doctors and medical personnelDisclosureNo significant relationships.
Impact of COVID19 Lockdown in Eating Disorders: A Multicenter Collaborative International Study
Authors: Etxandi M. , Baenas I. , Munguía L. , Granero R. , Mestre-Bach G. , Sánchez I. , Jimenez-Murcia S. , Fernandez-Aranda F. 
Published: September 2022

IntroductionCOVID19 lockdown is having a significant impact on mental health, patients with eating disorders (ED) are particularly vulnerable.Objectives1) To explore changes in eating and other psychological features due to confinement in patients with ED from various European and Asian countries; and 2) to assess differences related to diagnostic subtypes, age and geography.MethodsThe sample comprised 829 participants, diagnosed with an ED according to DSM-5 criteria from specialized ED units in Europe and Asia. Participants were assessed using the COVID19 Isolation Scale (CIES).ResultsOn one hand, patients with Binge Eating Disorder experienced the highest impact on weight and ED symptoms due to confinement. Together with subjects diagnosed with Other Specified Feeding and Eating Disorders (OFSED), they also experienced a deterioration in general psychological state. On the other hand, there was less symptomatic impact on people with Bulimia Nervosa or Anorexia Nervosa and asian and younger individuals appeared to be more resilient in this situation.ConclusionsThe impact of COVID varied by cultural context and individual variation in age and form of illness. Services may need to target preventive measures and adapting therapeutic approaches for the most vulnerable patients.DisclosureNo significant relationships.
The role of Theory of Mind and Empathy levels in Anxiety Disorders Symptomatology
Authors: Santarelli G. , Innocenti M. , Faggi V. , Miglietta V. , Colpizzi I. , Galassi F. , Castellini G. , Ricca V. 
Published: September 2022

Introduction
Theory of Mind (ToM) is defined as the ability to understand mental states of other people. Recent studies explored its role in various psychopathological disorders, but evidence lacks on the relationship existing between specific psychopathological domains and ToM.ObjectivesWe aimed to investigate the relationship between psychopathology of Anxiety Disorders (AD) and Theory of Mind.MethodsWe enrolled 35 patients admitted to the Psychiatric Unit of Careggi Hospital in Florence with diagnosis of AD. We administered them: Zung Anxiety Scale (ZSAS), Metacognition Questionnaire-30 (MCQ-30), and Reading the Mind in the Eyes (RMET). Pearson’s correlation was used to assess relationships between variables.ResultsA significant positive correlation was detected between RMET scores and ZSAS total scores (r=0.385, p=0.022), MCQ-30 Negative Beliefs about Uncontrollability and Danger subscale (MCQ-30-Neg, r=0.407, p=0.015), and MCQ-30 Cognitive Self-Consciousness subscale (MCQ-30-CSC, r=0.349, p=0.040).Correlations between the variables in the study and Reading the mind in the eyes total scores are shown.
RMET total scorerpMCQ-30-Neg0.4070.015MCQ-30-CSC0.3490.040MCQ-30 Positive beliefs about Worry0.0730.667MCQ-30 Lack of Cognitive Confidence-0.2450.155MCQ-30 Need to Control Thoughts0.3110.069ZSAS total scores0.3850.022ConclusionsSuch preliminary data suggest a relationship between Theory of Mind and AD psychopathology. In particular, some dimensions of AD psychopathology seem to predict higher Theory of Mind levels.DisclosureNo significant relationships.
Histamine intolerance and anxiety disorders: pilot cross-sectional study of histamine intolerance prevalence in cohort of patients with anxiety disorders
Authors: Nosková E. , Vochosková K. , Knop V. , Stopková P. , Kopeček M. 
Published: September 2022

IntroductionHistamine intolerance (HI) is a disorder associated with an impairment of ability to metabolize ingested histamine. The incidence of HI in general population is 1-3%. Clinical manifestation of HI contains nonspecific predominantly gastrointestinal, but also extraintestinal symptoms. HI could be primary with genetic predisposition, or secondary with lower activity of diaminooxidase (DAO) without positive genetic screening.ObjectivesThis study aims to evaluate the prevalence of HI by patients with anxiety disorders. HI can imitate anxiety symptoms, therefore we predict higher prevalence HI in patients with anxiety disorders than in general population.MethodsIt is observational cross-sectional study on cohort of anxious patients for detecting the prevalence of HI. Patients were screened by scale for histamine intolerance questionnaire. Patients with positive questionnaire were examined for serum DAO and genetically examined.Results113 patients fulfilled the HI questionnaire. From this cohort 35.4% (40 subjects) were positive at screening. Biomarkers of HI were screened only in case of positivity in this questionnaire.
Table No. 1: Results of our study from cohort with positive screening, 35.4 % (40 subjects).Genetic predispositionpositivity in risk allelenegativity in risk allelealtogetherSerum level of DAOpositive screening (DAO<10 U/ml)5 (4.4%)primary-genetically determined HI5 (4.4%)secondary HI10negative screening (DAO≥10 U/ml)14 (12.4%)16 (14.2%)30altogether1921ConclusionsThis pilot study shows that the prevalence of HI could be higher in group of patients with anxiety disorders than in general population. For further confirmation other studies with control group and larger cohort should be done.DisclosureNo significant relationships.
Differences in the effects of anxiolytics bromodihydrochlorophenylbenzodiazepine and fabomotizole in patients with anxiety disorders in dependence on their individually-typological features
Authors: Dorofeeva O. , Metlina M. 
Published: September 2022

IntroductionPersonalized approach in drug therapy is an essential line of modern psychiatry. Experimental and clinical studies of anxiolytics have shown differences in drug effects in dependence on genetically determined reactions to stress and personal features.ObjectivesTo evaluate of the therapeutic effects and effectiveness of bromodihydrochlorophenylbenzodiazepine and fabomotizole in dependence on individually-typological features of patients with anxiety disorders.Methods45 patients (mean age 33,3±9,7 years) with generalized anxiety disorder (n=22) and panic disorders with agoraphobia (n=23) participated in this open-label study. 13 patients treated with typical anxiolytics bromodihydrochlorophenylbenzodiazepine at dose 2 mg daily and 32 patients treated with atypical fabomotizole at dose 30 mg daily. The duration of treatment was 14 days. Minnesota Multiphasic Personality Inventory, Psychiatric Symptoms Severity Evaluation Questionnaire and CGI-E were administered.ResultsAsthenic features (high pessimism, anxiety, individualism) were revealed in 26 patients and stenic features (high impulsivity, rigidity and optimism) were revealed in 19 patients. Patients with asthenic features had tranquilo-activating effect of bromodihydrochlorophenylbenzodiazepine, whereas patients with stenic features had tranquilo-sedative effect. The tranquilo-activating effect of fabomotizole was revealed in patients with stenic features. High efficacy of bromodihydrochlorophenylbenzodiazepine was observed in patients with asthenic personality traits (χ 2 = 7,8), whereas in fabomotizole-in patients with stenic individual typological features (χ 2 = 9,1).ConclusionsPatients with stenic and asthenic features had differences in therapeutic effects and the effectiveness of anxiolytics. Personality features determine the sensitivity of patients with anxiety disorders to psychotropic drugs.DisclosureNo significant relationships.
Postnatal PTSD: Risks and Consequences
Authors: El-Hage W. 
Published: September 2022

Post-traumatic stress disorder (PTSD) occurs in 4% of all pregnancies during the postnatal period. This prevalence can increase in high-risk groups reaching a mean prevalence of 18%. Some risk factors are significantly associated with the development or exacerbation of postnatal PTSD, including prenatal depression and anxiety, pre-pregnancy history of psychiatric disorders, history of sexual trauma, intimate partner violence, emergency childbirth, distressing events during childbirth and psychosocial attributes. Maternal postnatal PTSD is highly associated with the difficulties in mother-infant bond and the postpartum depression. Evidence shows significant links between psychological, traumatic and birth-related risk factors as well as the perceived social support and PTSD following childbirth. The City Birth Trauma Scale can be recommended as a universal instrument for diagnosis of postnatal PTSD.DisclosureWissam El-Hage reports personal fees from Air Liquide, EISAI, Janssen, Lundbeck, Otsuka, UCB and Chugai.