bluuebunny/crossref_metadata_2025_split huggingface dataset:
Realisierung und Evaluation des Verwaltungsschalen-Metamodells
Authors: Miny Torben , Thies Michael , Heppner Sebastian , Gamaev Igor , Möller Leon , Kleinert Tobias 
Published: August 2022

Im Rahmen von Industrie 4.0 gilt das Konzept der Verwaltungsschale als eines der zentralen Ergebnisse. In diesem Beitrag wird das vom Lehrstuhl für Informations- und Automatisierungssysteme für die Prozess- und Werkstofftechnik der RWTH Aachen University entwickelte Python-SDK PyI40AAS zwei Jahre nach Beginn der Arbeiten vorgestellt. Es ist eine Realisierung des von der Plattform Industrie 4.0 veröffentlichten technologieneutralen UML-Modells für die Repräsentation von Informationen in der Verwaltungsschale. Zudem werden einige Design-Entscheidungen bei der Implementierung beleuchtet unddaraus Empfehlungen zur Weiterentwicklung des Metamodells abgeleitet.
Immunohistochemical evaluation of apoptosis inducing factor in missed abortion after IVF
Authors: Tral Tatiana G. , Tolibova Gulruchsor Kh. , Kogan Igor Yu. 
Published: August 2022

BACKGROUND: Apoptosis is involved both in the cyclic transformation and the functional activity of the endometrium during the menstrual cycle. Upon the onset of pregnancy, apoptosis is an important component of the placentation process. Moreover, changes in the apoptosis-inducing factor expression in the gravidar endometrium may lead to peculiarity both of trophoblast differentiation and the gestation course, regardless of the conception method.
AIM: to study the expression of apoptosis-inducing factor in abortive material in non-developing pregnancy after IVF.
MATERIALS AND METHODS: Histological and immunohistochemical analysis of the apoptosis-inducing factor expression were performed in 77 gravidar endometrium samples in patients with IVF pregnancy loss at 58 weeks and in 15 aborted materials that were received after abortion at similar week progression of pregnancy.
RESULTS: Significant decrease in the expression apoptosis-inducing factor in gravidar endometrium of the control group was revealed in comparison with the same parameter of the main group regardless of gravidar endometrium transformation variation. The highest expression apoptosis-inducing factor was detected in the main group gravidar endometrium that consists secretive and proliferative glands and incomplete gravidar transformation of the stroma.
CONCLUSIONS: High apoptosis-inducing factor expression both in the complete and incomplete gravidar transformation of the endometrium in aborted material after IVF pregnancy loss indicates the pathological apoptosis activation. Thus, the pathological apoptosis initiation occurs even before pregnancy onset in patients with infertility, endometrial dysfunction and chronic inflammatory process in the endometrium.
Autoamputation of the uterine adnexa due to torsion
Authors: Romanova Larisa A. , Rukhlyada Nikolay N. , Taits Anna N. , Malysheva Anna A. , Dudova Kristina A. 
Published: August 2022

Uterine adnexa torsion is an urgent surgical condition defined as total or partial twisting of an ovary and/or a fallopian tube on its vascular axis, causing circulatory failure. The diagnosis establishing before the operation is difficult due to absence of pathognomonic features of the clinical picture and instrumental diagnostics. In case of torsion the ovary is usually rotating around the infundibular-pelvic and uterine-ovarian ligaments, which causes vascular compression; ischemia and necrosis are progressing, leading to such complications as pelvithrombophlebitis, bleeding, infections, peritonitis, as well as calcification and autoamputation. Classical clinical picture of the uterine adnexa torsion is a sudden onset of continuous/intermittent pelvic or abdominal pain varying from moderate to severe, diffuse or isolated on one side. Pain syndrome could be of various duration, from several days to several months, and there could be such temporal episodes of pain in past history indicating prior partial torsion. This state can be accompanied by nausea, vomiting, fever, painful and frequent urination. The most precise instrumental diagnostics method in case of uterine adnexa torsion is colour Doppler ultrasonography, however, the final diagnosis is established only during the surgery. If the ovary is ischemic, adnexal detorsion is recommended, in case of necrosis adnexectomy is performed. When examining ultrasound of the pelvic organs, the left ovary is not visualized.
In our clinical case, according to the results of MRI of pelvic organs, the 38-year old patient had a cyst in posterior cul-de-sac with hemorrhagic or high-protein contents, and also the left ovary was not visible. During the laparoscopy an autoamputation of the left uterine adnexa due to torsion was found, as well as presence of necrotizing lesion in posterior cul-de-sac. Thus, laparoscopy is the only reliable method for diagnosing and treating adnexal torsion.
Réflexivité environnementale et (in)conscience de la crise écologique dans la littérature catastrophiste du XIXe siècle
Authors: Sukiennicka Marta 
Published: August 2022

Les récents travaux des historiens des sciences ont démontré que la conscience environnementale n’est pas le propre de notre « modernité réflexive ». Dès le XVe siècle, l’agir humain est envisagé comme facteur de changement dans diverses théories du climat qui oscillent entre l’optimisme et la peur de la catastrophe. Cette conscience climatique imprègne la littérature catastrophiste qui, dès le XIXe siècle, réfléchit sur les pouvoirs et les conséquences néfastes de la technoculture propre à la société industrielle. L’étude des œuvres de Jean-Baptiste Cousin de Grainville, d’Alfred Bonnardot et de Camille Flammarion permet d’observer comment la littérature à la fois s’empare des savoirs et détourne ceux qui portent sur l’économie de la nature et sur le climat, désamorçant les peurs et produisant un certain inconscient de la crise climatique.
« L’illusion du jardin décevant ». L’écriture de la crise dans les Jardins maures d’Aline Réveillaud de Lens
Authors: Sokołowicz Małgorzata 
Published: August 2022

Le but de cette contribution est de répondre à la question de savoir pourquoi dans les Jardins maures, cycle de nouvelles de l’écrivaine et peintre française de l’époque coloniale, Aline Réveillaud de Lens (1881-1925), l’imaginaire du jardin s’unit à celui de la crise. Avons-nous affaire tout simplement à la crise du jardin compris comme un espace paradisiaque ou s’agit-t-il d’autres crises encore que l’écrivaine évoque en se servant de cette union incongrue du jardin et de la crise ? Pour répondre à ces questions, nous avons divisé notre article en trois parties. La première présentera brièvement l’écrivaine et le cycle. La deuxième montrera que le jardin en crise peut cacher des crises propres à la société musulmane et la troisième décrira le jardin en crise comme la crise d’un certain rêve.
The COVID‑19 pandemic and the consumption of tobacco and nicotine-containing products: a literature review
Authors: Salagay O. O. , Sakharova G. M. , Antonov N. S. , Stadnik N. M. 
Published: August 2022

The fight against the COVID‑19 pandemic has led to the implementation of unprecedented measures in countries, including self-isolation, which have had a significant impact on people’s behavior and could lead to a change in the consumption of tobacco and nicotine-containing products. This article provides an overview of studies evaluating smoking behavior change and its impact on the prevalence of tobacco and nicotine use in the community at the start of the pandemic.Methods. The review included 31 published studies with data on smoking from more than 250,000 people from 24 countries that examined the following aspects of the problem: the association of smoking with COVID‑19 outcomes, identification of factors influencing smoking behavior at the beginning of the COVID‑19 pandemic, changing prevalence of tobacco and nicotine consumption at the start of the COVID‑19 pandemic, tobacco company actions during the pandemic, impact of misinformation about the association of smoking with COVID‑19 on consumers of tobacco and nicotine products, government actions to reduce the sale of tobacco and nicotine products during the pandemic time.Findings. All researchers identified mixed responses from consumers of tobacco and nicotine-containing products early in the pandemic. In equal proportions, smokers increased their tobacco/nicotine intake or reduced their smoking intensity. To a lesser extent, consumers quit smoking, but there were respondents who reported starting smoking due to the COVID‑19 pandemic.Conclusion. Monitoring the prevalence of consumption of tobacco and nicotine-containing products and the causes influencing it in the early periods of the COVID‑19 pandemic made it possible to identify additional effective measures, the implementation of which can prevent the growth of tobacco and nicotine consumption in such situations.
PERILAKU PEDAGANG DI PASAR WISATA PLAOSAN DALAM PERSPEKTIF ETIKA BISNIS ISLAM
Authors: Novita Ambarsari  , Luhur Prasetiyo  
Published: August 2022

This research is motivated by the trading activities of traders in the Plaosan Tourism Market, Magetan Regency which are not fully in accordance with Islamic business ethics. This study aims to determine the applied Islamic business ethics along with the factors that can influence and impact on business activities for traders at the Plaosan Tourism Market, Magetan Regency. This research uses qualitative methods, namely field research and uses a qualitative approach. Data collection techniques used are interviews, observation and documentation. As well as informants in this research are market managers, traders and buyers. The results of this study found that the behavior of traders in the Plaosan Tourism Market had not fully implemented the principles stated in Islamic business ethics, and there were several factors that influenced the behavior of these traders. While the impact of the behavior of traders causes negative and positive effects, both of which have an effect on the behavior of traders in the Plaosan Tourism Market. The impact of traders' behavior can affect business activities such as positive impacts on social and financial aspects. As well as the negative impact if traders do not provide good service it will have an impact on income which will decrease.
Abstrak: Penelitian ini dilatarbelakangi oleh kegiatan transaksi jual beli pedagang di Pasar Wisata Plaosan Kabupaten Magetan yang belum sepenuhnya sesuai dengan etika bisnis Islam. Penelitian ini bertujuan untuk mengetahui etika bisnis Islam yang diterapkan beserta faktor-faktor yang dapat mempengaruhi dan dampaknya terhadap kegiatan bisnis terhadap pedagang di Pasar Wisata Plaosan Kabupaten Magetan. Penelitian ini menggunakan metode kualitatif, yakni penelitian lapangan dan menggunakan pendekatan kualitatif. Teknik pengumpulan data yang dilakukan adalah wawancara, observasi dan dokumentasi. Serta informan ada penelitian ini adalah pengelola pasar, pedagang serta pembeli. Hasil penelitian ini menemukan bahwa perilaku pedagang di Pasar Wisata Plaosan belum sepenuhnya menerapkan prinsip yang telah tertera pada etika bisnis Islam, serta terdapat beberapa faktor yang mempengaruhi perilaku pedagang tersebut. Sedangkan dampak perilaku pedagang menimbulkan pengaruh negatif dan juga positif yang keduanya sama-sama berpengaruh kepada perilaku pedagang di Pasar Wisata Plaosan. Dampak perilaku pedagang tersebut dapat mempengaruhi terhadap kegiatan bisnis seperti dampak positif bagi aspek sosial maupun finansial. Serta dampak negatifnya apabila pedagang melakukan pelayanan kurang baik maka akan berdampak pada pendapatan yang akan menurun.
Movimentos sociais e Geografia: desenvolvendo o pensamento crítico no oitavo ano do ensino fundamental.
Authors: Goronski Maysa , Batista Natália 
Published: August 2022

Este plano de aula tem por objetivo utilizar de metodologias ativas para abordar os movimentos sociais nas aulas de Geografia, para as turmas de oitavo ano. Um assunto que muitas vezes é tratado como irrelevante, e que a sociedade não o conhece de fato. As metodologias ativas que serão utilizadas serão a construção de portfólios e uma sala de aula invertida, visando principalmente o aprendizado e o pensamento crítico do estudante, e que o mesmo faça indagações sobre o assunto, relacionadas talvez com sua vivência ou com seu conhecimento vivido. Os movimentos sociais estão previstos na Base Comum Curricular, para abordá-los foi realizado levantamento de alguns artigos, que trazem conceitos e aprofundamento deste assunto. Assim, conclui-se que a Geografia é uma ciência ampla, e que assuntos como o do “Movimento Sociais”, são de extrema importância para o ensino escolar e para a sociedade.
Incidence of osteoporosis and osteopenia in men with HIV+ and a history of Kaposi sarcoma
Authors: Cornejo-Juárez Patricia 
Published: August 2022

Abstract
Background: Low bone mineral density (BMD) is a common complication of chronic HIV infection, reported between 30%-67% for osteopenia, and between 15%-30% for osteoporosis. Kaposi Sarcoma (KS) is an angioproliferative disease, mediated by cytokines which contributes to inflammation. The objective was to assess the prevalence of BMD in a cohort of HIV+ men with a history of KS.Methods: A retrospective study was performed from January 2019 to March 2021, in men over the age of 40 years and/or with more than 3 years of antiretroviral drugs. Odds Ratios with 95% Confidence Intervals were calculated. P values of ≤0.05 were considered statistically significant. Results: Eighty-four patients were included; mean age was 45.9 ± 8.8 years, and mean time from HIV diagnosis was 9.7 ± 6.8 years. The median baseline CD4+ was 102 cells (IQR 40, 216), and the median viral load was 143 582 copies/ml (IQR 26 527, 341 500). At the time of Dual X-ray Absorptiometry, the median CD4+ count was 361 cell/mL (IQR 225, 518) and the HIV-viral load was undetectable in 80 patients (95.2%). Osteoporosis was documented in 23.8% and osteopenia in 53.6%. The analysis comparing main risk factors, including different ARV drugs for low BMD did not show statistical differences. In the multivariate analysis, NNTRI and disseminated KS were found as protective factors for low BMD. Conclusions: The low BMD reported in this cohort may be related to several risk factors, it is advisable to establish preventive measures for BMD loss, regardless of age.
Clinicopathological and prognostic significance of heat shock proteins in hepatocellular carcinoma: a systematic review and meta-analysis
Authors: Xiang Dan , Jiang Mengdan , Chen Ya , Liu Chengjiang , Li Leilei 
Published: August 2022

Abstract
Background: Several studies were conducted to explore the clinicopathological characteristics and prognostic value of heat shock proteins in hepatocellular carcinoma (HCC). However, the results remain controversial. To address this gap, we conducted a systematic review and meta-analysis.Methods: The eligible literature was obtained from PubMed, Cochrane library, Web of science, Embase, Chinese National Knowledge Infrastructure and Wan Fang databases. We used the odds ratio (OR) and hazard ratio (HR) as the suitable parameters to assess the clinicopathological features and prognostic value of heat shock proteins (HSPs) in hepatocellular carcinoma (HCC) patients. The statistical analysis was performed using STATA 16.0 software.Results: After inclusion and exclusion of studies based on the eligibility criteria, a total of 1809 hepatocellular carcinoma patients from 19 studies were finally included. The results showed that heat shock proteins expression was not associated with overall survival (OS) of HCC patients (HR=1.34, 95%CI = 0.84-2.12, P = 0.216). In addition, the pooled analyses suggested that HSPs expression was significantly correlated with the unfavorable conditions for higher tumor differentiation (OR = 1.34, 95%CI = 1.08-1.66, P = 0.008), vascular invasion (OR = 1.29, 95%CI = 1.01-1.65, P = 0.039) and lymphatic metastasis (OR=1.63, 95%CI = 1.08-2.46, P = 0.021). Meanwhile, the pooled HR showed significant correlation between heat shock protein 27 (HSP27) expression and overall survival of HCC patients (HR=1.69, 95%CI = 1.24-2.31, P = 0.001).Conclusions: Our meta-analysis confirms that overexpression of HSPs may be directly involved in tumor differentiation and distant metastasis but cannot be considered as a biomarker for predicting the prognosis of HCC. However, the expression of HSP27 could be a potential prognostic predictor of HCC.
State-of-the-Art Review of Organic Phase Change Materials for Low-Temperature Thermal Energy Storage Technology
Authors: Bidiyasar Rahul , Kumar Rohitash , Jakhar Narendra 
Published: August 2022

Abstract
The demand for thermal comfort by increased population results in growing energy consumption worldwide, resulting in deterioration of the global climate caused by greenhouse gas emissions. The latent heat storage technique is efficient because it can be operated at a minimum range of temperature. Especially, Phase change materials (PCMs), which have a tendency for solid-liquid phase transformation, have become a topic of great research interest. Organic PCM may be utilized in many thermal storage system applications. But none of the organic PCM in its pure form possesses all of the required properties for usage in real applications. So, to use a particular PCM in a variety of applications, eutectic PCM may be designed. The thermal characteristics like phase transition temperature and enthalpy of fusion may easily be adjusted by adding at least two PCMs to prepare eutectics with a lower melting temperature and higher energy density than either of the individual PCMs. The optimal composition of PCMs in the eutectic material and the lowest melting point are computed using the Schroder-Van Laar model. Also, because of the poor heat conduction of eutectic PCM, it puts a barrier to utilization in real-world applications. Various materials can be added in order to optimize thermal conductivity of these eutectic PCMs. Therefore, eutectic PCMs have the potential to be utilized for low-temperature heat energy storage practical applications and will progressively be included in worldwide heat management solutions in the coming years, and their price should indicate that they are worth the investment.
L-Arginine-Loaded Gold Nanocages Mitigates Myocardial Ischemia/Reperfusion Injury by Promoting NO Production and Maintaining Mitochondrial Functions
Authors: Wang Zekun , Yang Nana , Cao Huanhuan , Hou Yajun , Fu Xiaoting , Hu Gaofei , Zhu Pengfei , Li Yuqing , Yin Chenyang , Yang Endong , Liao Ziyu , Wang Weiyun , Sun Dongdong , Fan Cundong , Zheng Lemin 
Published: August 2022

Abstract
Nitric oxide (NO) has the potential to ameliorate myocardial ischemia/reperfusion injury (MI/RI), and has emerging as key molecular for drug design. However, NO can be oxidized to more toxic peroxynitrite in the presence of reactive oxygen species (ROS), and cause secondary damage to cardiomyocytes. Herein, L-Arginine-loaded selenium-coated gold nanocages (AASP) were designed and synthesized. AASP after PCM modification achieved cardiomyocytes-targeted recognition, enhanced cellular uptake and photoacoustic imaging in vitro and in vivo, which significantly inhibited oxygen glucose deprivation/re-oxygenation (OGD/R)-induced H9C2 cells cytotoxicity and apoptosis. Mechanism investigation revealed that Nano-selenium firstly exhausted ROS, which prevented NO oxidation. L-arginine (Arg) loaded in gold nanocore was catalyzed by nitric oxide synthase (eNOS) to produce NO, which in turn blocked ROS release by regulating mitochondrial permeability transition pore (mPTP) closing, which maintained mitochondria functions, inhibited apoptosis. AASP administration in vivo effectively improved myocardial functions and vascular remodeling, inhibited myocardial apoptosis and fibrosis, and eventually attenuated MI/RI of rats. Transcriptomic analysis revealed that AASP relieved MI/RI of rats mainly by maintaining mitochondrial functions and regulating NO signal. Moreover, AASP showed good safety and biocompatibility in vivo. Taken together, our findings validated the rational design that L-Arginine-loaded selenium-gold nanocages ameliorated MI/RI of rats by promoting nitric oxide production and maintaining mitochondrial functions, which could be a more efficient way to treat MI/RI.
Study of the Effect of Drying on the Pore Structure and Characteristics of Spontaneous Combustion of Immersed Lignite
Authors: Guo Wei , Zhang Chunhua , Han Yongliang 
Published: August 2022

Abstract
To reveal the influence mechanism of the drying process of immersed coal on the spontaneous combustion characteristics and the change rule of the spontaneous combustion process, in this research, we measured the pore structure of coal with low-field nuclear magnetic resonance, the mass change during coal oxidation with thermogravimetry, and the change of the functional groups with Fourier transform infrared spectroscopy. Additionally, we conducted a temperature-programmed spontaneous combustion experiment with coal samples with different treatments to study the oxygen consumption rate and heat release. The results showed that the pore volume content of the pores with pore sizes of less than 100 nm was significantly reduced. The diameter range of 100–1000 nm was gradually generated after 8 h of coal drying, and the proportion of large pores and cracks larger than 1000 nm increased significantly during the drying process of the immersed coal. The oxygen consumption rate and the heat release rate were significantly affected by the degree of dryness and the temperature of coal samples in the temperature-programmed process. The turning point temperature was 140°C. Below the turning point temperature, the raw coal had the fastest oxygen consumption and maximum heat release. When the coal temperature was higher than 140°C, the oxygen consumption rate and the heat release rate of the coal sample that was dried for 24 h were higher than those for the raw coal, followed by the samples that were dried for 8 h and dried for 48 h.
PDGF regulates proliferation of malignant mesothelioma cells via CTGF protein control
Authors: Fujii Makiko , Suehiro Tomoya , HOANG NGUYEN , Matsuki Tohru , Mine Yuichi , Nikawa Hiroki , Asano Katsura 
Published: August 2022

Abstract
Malignant mesothelioma (MM) is a disease caused by exposure to refractory asbestos. The number of patients constantly increases globally because of the 20-40-year latency period. This study aimed to perform small-molecule inhibitor screening to explore MM cell signaling and identify new targets for molecular therapy. Our results show that not only platelet-derived growth factor receptor (PDGFR) inhibitors but also small interfering RNA that target PDGFR-α or PDGFR-β suppressed the proliferation of MM cell lines. Knockdown of PDGFR-α and PDGFR-β expression reduced connective tissue growth factor (CTGF) protein expression, which is known to affect MM cell proliferation and malignancy. Platelet-derived growth factor (PDGF) treatment induced the elevation of CTGF protein within 30 min without affecting CTGF mRNA levels in MM cells. Based on the knowledge that the protein kinase B (AKT)-mTOR pathway participates in mRNA translational control, we found that PDGF activates AKT/mTOR signaling in MM cells, and the blockade of AKT activation inhibited CTGF protein upregulation induced by PDGF. These results demonstrated that the proliferation of MM cells was significantly controlled by the PDGF–AKT–CTGF pathway. Our findings suggest that PDGF–PDGFR may be a possible therapeutic target in patients with MM.