bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of radar plots with the Yk-index to identify which authors contributed the most to the journal of Medicine in 2020 and 2021: A bibliometric analysis
Authors: Shao Yang , Chien Tsair-Wei , Jang Fong-Lin 
Published: November 2022

Background:
A consensus exists that the first author and corresponding author make the most contribution to the publication of an article. The Y-index has been proposed to assess the scientific achievements of authors, institutions, and countries/regions (AIC/R for short) based on the number of first-author publications (FPs) and corresponding-author publications (RPs). Nonetheless, the Y-index is defined in terms of count and radian (represented by j and h) instead of using the relative radius and angle degree to simplify understanding. In the literature, a method for drawing radar diagrams online with the Y-index is also lacking. This study was conducted to enhance the Y-index with an additional relative radius denoted by k and the angle degree represented by h* (named Yk-index), include easy-to-use features (e.g., copying and pasting) for the delivery of the online Radar-Yk, and identify which one of AIC/R contributed the most to a scientific journal.

Methods:
From the Web of Science (WoS) database, we downloaded 9498 abstracts of articles published in the journal of Medicine (Baltimore) in 2020 and 2021. Three visual representations were used, including a Sankey diagram, a choropleth map, and a radar diagram, to identify the characteristics of contributions by AIC/R to Medicine (Baltimore) using the Yk-index (j, k, h*). A demonstration of Rada-Yk with easy-to-use features was given using the copy-and-paste technique.

Results:
We found that Qiu Chen (China), Sichuan University (China), China, and South Korea (based on regions, e.g., provinces/metropolitan areas in China) were the most productive AIC/R, with their Yk equal to 27,715, 12415.1, and 2045, respectively; a total of 85.6% of the published articles in Medicine (Baltimore) came from the 3 countries (China, South Korea, and Japan); and this method of drawing the Radar-Yk online was provided and successfully demonstrated.

Conclusion:
A breakthrough was achieved by developing the online Radar-Yk to show the most contributions to Medicine (Baltimore). Visualization of Radar-Yk could be replicated for future academic research and applications on other topics in future bibliographical studies.
Efficacy of combination colonoscopy using modified cap-assisted and water-exchange colonoscopy with prone position for detection of colorectal adenomas
Authors: Ko Jihwan , Kim Hyung Wook , Kang Dae Hwan , Choi Cheol Woong , Han Seong Ho , Ko Byung Gu 
Published: November 2022

The efficacy of cap-assisted and water-exchange colonoscopy, individually or in combination for adenoma detection is well documented. Moreover, prone positioning colonoscopy may also improve adenoma detection by decreasing loop formation. However, the efficacy of triple-combination colonoscopy using the above methods for adenoma detection is unclear. This study aimed to compare the effectiveness of combining modified cap-assisted and water-exchange colonoscopy with prone position (CWP) and conventional colonoscopy (CC) for adenoma detection.
A total of 746 patients who underwent either CWP or CC, performed by 2 board-certified gastroenterologists between December 2019 and March 2020, were investigated retrospectively. Cap-assisted colonoscopy was modified using hooking and dragging maneuver. We evaluated the polyp detection rate (PDR), adenoma detection rate (ADR), and the mean number of adenomas detected per procedure (MAP).
There was no significant difference in sex, age, the indication of colonoscopy and quality of bowel preparation between the 2 groups. PDR, ADR, and proximal colon MAP were significantly higher in the CWP group than in the CC group (PDR: 84.9% vs 59.8%, P < .01; ADR: 70.1%, vs 49.2%, P < .01; proximal colon MAP: 1.24 vs 0.55, P < .01).
CWP is more effective than CC for PDR, ADR, and proximal colon MAP. Although it may facilitate adenoma detection, further studies assessing the synergistic or complementary effects of combining these methods are needed.
The mean kurtosis (MK) is more sensitive diagnostic biomarker than fractional anisotropy (FA) for Parkinson’s disease: A diagnostic performance study and meta-analysis
Authors: Huang Songtao , Dong Yanchao , Zhao Jiaying 
Published: November 2022

Background:
The mean kurtosis (MK) and fractional anisotropy (FA) in patients of Parkinson’s disease (PD) are usually measured by diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI), separately.

Methods:
In this study we perform a meta-analysis to discuss which noninvasive biomarker is more advantageous for PD, MK, or FA. Databases including Medline via PubMed, the Cochrane Central Register of Controlled Trials, Embase via OVID and China National Knowledge Infrastructure. Databases are searched up to December 31st, 2019. Four brain regions are identified for analysis based on data extracted from articles.

Results:
The articles contain 5 trials with 274 total PD patients and 189 healthy controls (HCs). The results show not only significantly higher MK values of putamen, caudate, globus pallidus in PD compared to that of HCs (weighted mean difference [WMD] = 0.06, 95% CI = 0.02–0.09, P = .002, WMD = 0.03, 95% CI = 0.01–0.067, P = .01, WMD = 0.18, 95% CI = 0.11–0.24, P < .00001), but also a significantly higher FA in caudate of PD compared to HCs (WMD = 0.02, 95% CI = 0.00–0.03, P = .006).

Conclusion:
This indicates that the sharp difference detected between PD patients and HCs can be detected by DKI and DTI. By further discussing results, we found that MK could be more sensitive diagnostic biomarker than FA toward PD diagnosis.
Effects of midazolam co-induction to general anesthesia: A randomized clinical trial
Authors: Mihalj Mirko , Karlović Zoran , Vladić-Spaić Dajana , Matić Boris , Mikulić Iva , Mikulić Vinka , Golubović Vesna 
Published: November 2022

Background:
This study aimed to determine the potential advantages of midazolam co-induction with general anesthesia (GA) over the use of propofol alone.

Methods:
We conducted a randomized, placebo-controlled, single-blinded clinical trial of 102 patients, aged 18 to 65, American Society of Anesthesiologists II and III, who underwent elective laparoscopic gallbladder surgery. Patients were randomly divided into 3 groups: the placebo group (C) received 1 mL of 0.9% saline intravenously and the test groups received intravenous midazolam at doses of 0.03 mg/kg (M1) or 0.06 mg/kg (M2) before induction of GA. We assessed effects of midazolam co-induction on arterial pressure and heart rate (HR) in the early stage of GA prior to surgical incision and effects on perioperative and postoperative glycemia and cortisol levels. Systolic/mean/diastolic (SAP/MAP/DAP) arterial pressure and HR were measured 4 times (preoperative, on the third, sixth and ninth minute after atracurium administration). Cortisol was measured on 3 occasions (preoperatively, 60 minutes after surgical incision, and the following morning) and glucose on 4 occasions (preoperatively, 15 and 60 minutes after incision, and the following morning). We also assessed the incidence of postoperative anxiety, postoperative nausea and vomiting (PONV), and propofol requirement for induction.

Results:
SAP/MAP/DAP were significantly higher in M2 immediately after induction compared to the other study groups (P = .002/.004/.013). Midazolam co-induction led to a significant reduction in postoperative anxiety (P = .03), reduced cortisol concentration 60 minutes after surgical incision (P < .001) and propofol requirements (P < .001).

Conclusion subsections:
Midazolam co-induction prevented a marked decline in SAP/MAP/DAP immediately after induction of GA, led to reduced postoperative anxiety and cortisol response to surgery, and reduced propofol requirements for induction.
A case report on the role of endoscopic retrograde cholangiopancreatography in the diagnosis of hemosuccus pancreaticus
Authors: Moon Sung Mi , Paik Kyu-Hyun , Kim Ji Chang , Park Won Suk 
Published: November 2022

Rationale:
Hemosuccus pancreaticus (HP) is a rare cause of gastrointestinal bleeding that sometimes leads to life-threatening conditions. However, the diagnosis of HP is often delayed due to its rarity and intermittent signs of bleeding, making it challenging to determine the source of bleeding in some patients.

Patient concerns:
An 83-years-old man was transferred to our hospital for evaluation of the source of intermittent upper gastrointestinal bleeding involving melena and worsening anemia.

Diagnosis:
HP was diagnosed via endoscopic retrograde cholangiopancreatography (ERCP) and sequential angiography using a multidisciplinary approach.

Interventions:
Initial upper and lower gastrointestinal endoscopies did not reveal any source of bleeding. Emergency upper endoscopy performed when the patient had hematochezia and hypotension confirmed a spurt of bleeding from the major duodenal papilla. However, contrast-enhanced computed tomography and angiography could not identify the source of the bleeding from the major duodenal papilla. ERCP for inducing bleeding from the source and indicating the bleeding point was performed according to the decision of the multidisciplinary team. Immediately thereafter, sequential angiography was performed and HP, due to the rupture of a pseudoaneurysm of the splenic artery, was diagnosed. As a result, surgical resection of the pancreas could be avoided by accurately embolizing the bleeding focus of HP using a multidisciplinary team approach.

Outcomes:
The patient was discharged in a hemodynamically stable condition. There was no further gastrointestinal bleeding or procedure-related complication until 6 months after discharge.

Lessons:
HP should be considered by endoscopists during the differential diagnosis of intermittent upper gastrointestinal bleeding in patients with a history of pancreatitis. A multidisciplinary team approach is an effective method to determine the source or location of bleeding, which may reduce mortality and morbidity by avoiding additional pancreatectomies.
Nerve root compression due to lumbar spinal canal tophi: A case report and review of the literature
Authors: Wang Kai , Yang Quan-Zeng , Wen Hao-Nan , Hai Yun-Xaing , Gao Guo-Dong , Song Min 
Published: November 2022

Rationale:
Gout in the spine and adnexa is rare in clinical practice and can also be easily misdiagnosed, we reported a patient with nerve root compression due to lumbar gout stones in the lumbar spinal canal.

Patient concerns:
A 51-year-old male was admitted to the hospital with lumbar pain with numbness in the left lower limb for more than 6 months. The physical examination showed that tenderness and percussion pain were present at L4-S1 spinous process. Straight leg raise test: 50° on the left side were positive. Laboratory tests showed that the sUA was 669 μmol/L, MRI of the lumbar spine showed that cystic T1WI low signal and T2WI mixed high signal shadows were seen in the spinal canal at the level of L4-L5.

Diagnoses:
Combining with lab examinations, imaging examinations, and histopathological results, the patient was diagnosed with lumbar spinal canal tophi.

Interventions:
After active improvement of all examinations, the patient underwent surgical treatment with decompression and internal fixation of the L4-L5 segment.

Outcomes:
After surgery, the patient’s symptoms improved and muscle strength returned to normal. Among the 95 previously reported patients with lumbar gout, the ratio of men to women was 2.96:1, and the peak age group of incidence was 56 to 65 years. The onset of the disease was mainly in a single segment of the lumbar spine, with 34.41% of all cases occurring at the L4-L5 level. 61.05% of the patients had a history of gout attacks or hyperuricemia, and the most frequently involved site was the foot and ankle, followed by the wrist. Sixty-seven patients underwent surgical treatment, and 22 chose conservative treatment, with overall satisfactory results.

Lessons subsections:
The incidence of lumbar gout is low and relatively rare in the clinic and pathological biopsy is still the gold standard. Vertebral plate incision and decompression are often selected for surgical treatment, and whether to perform fusion should be comprehensively considered for the destruction of vertebral bone by gout and the reasonable selection of the extent of surgical resection. Whether choosing surgical treatment or conservative therapy, the control of uric acid levels should be emphasized.
Surgical treatment of recurrent postoperative discal pseudocyst: A case report and literature review
Authors: Wang Hong , Wang Shuang , Yu Hailong , Chen Yu , Zheng Liang , Ma Junxiong 
Published: November 2022

Introduction:
Postoperative discal pseudocyst (PDP) is rare. Few studies have reported on the recurrence of PDPs, and there is a lack of understanding of their clinical features and treatment methods. This study discusses the clinical characteristics and treatment of recurrent PDPs.

Patient concerns:
A 25-year-old man presented with radiating pain and numbness in the lateral left calf and dorsum of the foot.

Diagnosis:
Postoperative discal pseudocyst.

Interventions:
He underwent lumbar discectomy, which provided immediate postoperative relief. However, the symptoms recurred 45 days later. Magnetic resonance imaging (MRI) showed a lesion compressing the dura and nerve roots at the site of the previous surgery. The lesion appeared hypointense on T1-weighted imaging and hyperintense on T2-weighted imaging. The patient was treated conservatively for 1 month without significant relief. He then underwent lumbar discectomy and cyst removal, which immediately relieved his symptoms. However, 27 days later, the patient again developed the same symptoms. MRI examination showed recurrence of PDP. As 1 month of conservative treatment failed to relieve the patient’s symptoms, we performed posterior instrumented lumbar fusion and cyst removal.

Outcomes:
The patient’s symptoms disappeared, and have not recurred for 1 year at the time of writing.

Conclusions:
PDP is a rare complication of lumbar discectomy. Repeat lumbar discectomy can effectively treat PDP, but the cyst can recur. We, for the first time, used posterior instrumented lumbar fusion to successfully treat recurrent PDP.
Well-Differentiated Grade 3 Neuroendocrine Tumors
Authors: Boutin Mélina , Mathews Angela , Badesha Jasleen , Paul Ashley , Safro Maria , Gill Sharlene , Stuart Heather C. , Schaeffer David , Farnell David , Loree Jonathan M. 
Published: November 2022

Objectives
We evaluated a population-based cohort of metastatic well-differentiated grade 3 gastroenteropancreatic neuroendocrine tumors (G3 NETs) to describe their characteristics, prognosis, and treatment outcomes.

Methods
The British Columbia provincial database was queried for G3 NETs diagnosed 2004 to 2021, and charts were reviewed to describe clinical features and outcomes.

Results
Forty-one patients were identified, most were diagnosed with pancreatic (58.5%) or midgut (26.8%) primary tumor and Ki-67 was less than 55% in 68.3%. The primary was resected in 19 (46.3%) with median disease-free survival of 25.2 months. Once metastatic, patients received a median of one line of systemic therapy. Median overall survival with metastatic disease was 33.8 months. Median progression-free survival was longest in patients treated with capecitabine-temozolomide (20.6 months) or somatostatin analogs (7.9 months), while etoposide-platinum provided little benefit (2.4 months). Limited data of efficacy for targeted therapies and radionuclide therapy was available. Seven patients (17.1%) were also treated with local therapies, which were associated with improved overall survival (median not reached, hazard ratio, 0.23; P = 0.012).

Conclusions
Capecitabine-temozolomide and somatostatin analogs were associated with clinically meaningful benefit, and use of local therapies provided benefits in selected patients. Multidisciplinary discussion is essential to optimize individual outcomes in this heterogeneous population.
The Use of Vasopressors During Deceased Donor Pancreas Procurement Decreases the Risk of Pancreas Transplant Graft Failure
Authors: Froehlich Mary , Koizumi Naoru , James Rosy M. , Christian Ana Gayle Weatherly , Choubey Ankur , Patel Sunil , Ortiz Jorge , Siskind Eric J. 
Published: November 2022

Objectives
The objective of this study was to identify the effect of various vasopressors on pancreas graft failure and patient survival.

Methods
A retrospective analysis of the United Network for Organ Sharing database was performed between 2000 and 2019. Patient and graft survival rates were analyzed up to 5 years posttransplant.

Results
The data included 17,348 pancreas transplant recipients: 12,857 simultaneous pancreas-kidney, 1440 pancreas transplant alone, and 3051 pancreas-after-kidney transplant recipients. Use of dopamine during deceased donor procurement increased graft failure by 18% (hazard ratio [HR], 1.18; P < 0.001). Absence of vasopressor caused graft failure to rise by 8% (HR, 1.08; P = 0.09). Dopamine increased the mortality rate by 37% (HR, 1.37; P < 0.001) and the absence of vasopressor increased the mortality rate by 14% (HR, 1.14; P = 0.02). Phenylephrine and norepinephrine reduced the mortality rate by 10% (HR, 0.90; P = 0.05) and 11% (HR, 0.89; P = 0.10), respectively.

Conclusions
The absence of vasopressor use or the use of dopamine is associated with a higher risk of both pancreas transplant graft failure and recipient mortality. The use of phenylephrine and norepinephrine reduces the risk of mortality. This information should guide deceased donor hemodynamic support management in anticipation of pancreas procurement for future transplantation.
Association Between Family History and Risk of Pancreatic Cancer in Patients With BRCA1 and BRCA2 Pathogenic Variants
Authors: Shah Ishani , Silva-Santisteban Andy , Germansky Katharine A. , Kandasamy Cinthana , Mlabasati Jack , Huang Dora C. , Wadhwa Vaibhav , Bilal Mohammad , Sawhney Mandeep S. 
Published: November 2022

Objectives
Current guidelines limit pancreatic cancer screening to those BRCA1/2 patients who have a family history of pancreatic cancer. We aimed to assess the association between family history and risk of pancreatic neoplasms in BRCA1/2 patients.

Methods
We reviewed medical records of BRCA1/2 patients followed at our institution between 1995 and 2020. Family history was defined as those with a first-degree relative with pancreatic cancer. We compared the incidence and prevalence of pancreatic neoplasms between patients with and without family history of pancreatic cancer.

Results
We identified 56 BRCA1/2 patients with family history and 238 without family history of pancreatic cancer. No difference between these groups was noted in age, race, or sex. Mean follow-up interval for BRCA1/2 patients was 4.6 years (range, 0–19.7 years). There was no significant difference in prevalence (19.6% vs 12.6; P = 0.3) or incidence (29% vs 14.1%; P = 0.08) of branch-duct intraductal papillary mucinous neoplasm between the 2 groups. No association between family history and pancreatic cancer risk was noted. Only 1 of 10 BRCA1/2 patients with pancreatic cancer had a family history.

Conclusions
Our results do not support using family history to determine eligibility for pancreatic cancer screening.
Concurrent Overexpression of Two Hyaluronidases, KIAA1199 and TMEM2, Strongly Predicts Shorter Survival After Resection in Pancreatic Ductal Adenocarcinoma
Authors: Kudo Yuzan , Sato Norihiro , Oba Takuya , Adachi Yasuhiro , Amaike Takao , Koga Atsuhiro , Kohi Shiro , Noguchi Hirotsugu , Nakayama Toshiyuki , Hirata Keiji 
Published: November 2022

Objectives
Pancreatic ductal adenocarcinoma (PDAC) is characterized by accelerated hyaluronan metabolism. Our previous studies have shown increased expression of 2 newly identified hyaluronidases, KIAA1199 and transmembrane protein 2 (TMEM2), in PDAC. However, the relationship between these 2 hyaluronidases is unknown. In the present study, we investigated the correlation between KIAA1199 and TMEM2 expression in PDAC.

Methods
Using quantitative real-time reverse transcription polymerase chain reaction, we analyzed KIAA1199 and TMEM2 mRNA expression in 11 PDAC cell lines and frozen tissues from 12 patients with PDAC. We used immunohistochemistry to investigate expression patterns of KIAA1199 and TMEM2 in archival tissues obtained from 92 patients with PDAC who underwent surgical resection. We compared survival between 4 groups according to expression patterns of KIAA1199 and TMEM2.

Results
We found a significantly positive correlation between KIAA1199 and TMEM2 mRNA in PDAC cell lines and tissues. Immunohistochemical analysis found that median overall survival was 30.2 months in patients with low expression of KIAA1199 and TMEM2 and 12.5 months in those with high expression of both. Patients with high expression of KIAA1199 and TMEM2 had significantly shorter survival than other patient groups.

Conclusions
Concurrent overexpression of these 2 hyaluronidases could be a strong prognostic marker in PDAC.
Bioinformatics Analysis of Differentially Expressed Genes and Related Pathways in Acute Pancreatitis
Authors: Zhong Rui , Luo Xujuan , Xu Jin , Jiang Xin , Yan Yongfeng , Shi Xiaomin , Peng Yan , Tang Xiaowei , Fu Xiangsheng 
Published: November 2022

Objectives
The aim of this study was to investigate differentially expressed genes (DEGs) in the acute pancreatitis (AP).

Methods
Microarray datasets GSE3644, GSE65146, and GSE109227 were downloaded from Gene Expression Omnibus database. Then, a comprehensive analysis of these genes was performed using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis, protein-protein interaction network analysis, core gene correlation analysis, and transcription factor prediction. Finally, the differences in the expression of hub genes in human organs and survival analysis in pancreatic carcinoma were evaluated.

Results
A total of 137 DEGs were screened, 128 genes were upregulated, and 9 genes were downregulated. Functional enrichment analysis demonstrated that these genes were mostly enriched in biological processes such as positive regulation of macroautophagy, cellular component such as focal adhesion, molecular function such as cadherin binding involved in cell-cell adhesion, and multiple pathways including tight junction. CDH1 and VCL were identified as hub DEGs, close interactions with MAZ, were expressed in human pancreas organs in various degrees. The high expression of CDH1 and VCL was significantly associated with poor prognosis in pancreatic carcinoma.

Conclusions
The core genes CDH1 and VCL may play a key role in AP through regulation by MAZ.