bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer mortality in the older adults in China, 2005-2016: a joinpoint and age- period-cohort analysis
Authors: Yang Kaiyue , Liu Bowei , Guo Hong , Lin Kangqian , Ma Zhenrong , Ren Lingchen , Guo Xiaoli , Hu Youbing , Jia Huaimiao , Hu Yunhua , Song Guanling , Yan Yizhong 
Published: September 2022

Abstract
Objective
To explore the epidemiological characteristics and mortality trends of cancer in the older adults in China from 2005 to 2016 and to provide strategies for the prevention and treatment of cancer.
Methods
Stratified analysis was conducted on the cancer mortality data of the older adults aged ≥ 60 years in China, which were selected from the Chinese Cancer Registry Annual Report and GLOBOCAN 2020 database. The Joinpoint regression model was used to estimate mortality trends. The age-period-cohort model was used to explore the effects of age.
Results
1. Cancer mortality in the older adults in China showed a decreasing trend from 2005 to 2016 (APC=-1.23%, P < 0.001). 2. Cancer mortality in the older adults in rural areas was higher than that in urban areas from 2005 to 2016, but the urban-rural difference gradually narrowed as the urban-rural ratio was risen from 0.79 in 2005 to 1.01 in 2016 (t = 4.32, P < 0.01). 3. The cancer mortality in the older adults in older women and rural areas showed a decreasing trend (women: APC60-69=-1.08%, APC70-79=-1.85%, APC80-84=-0.83%; rural: APC60-69=-3.31%, APC70-79=-3.12%, APC80-84=-1.22%; all P < 0.05). Older adults born before 1935 had a higher risk of death. 4. Lung, stomach, liver, esophageal, and colorectal cancers were the five most dominant cancers in the older adults in China.
Conclusion
Cancer mortality in the older adults in China showed a decreasing trend between 2005 and 2016 but it was still higher than the world average. We recommend to focus on the early cancer detection in the older adult men and in rural areas.
WITHDRAWN: Local climate influence on size and orientation of nest cavities of a North African endemic woodpecker
Authors: BADIS MEHDI , HAMDI NABIL 
Published: September 2022

Abstract
Levaillant’s Woodpecker Picus vaillantii is a primary cavity nester endemic to the forests of northern Africa, including the cedar forest in Aures Mountains. This species, as like all woodpeckers, is important for the integrity of ecosystems, especially since it provides nesting cavities and contributes to the availability of habitats for several secondary cavity nesters that cannot dig their own nests. To characterize for the first time the Levaillant’s Woodpecker’s nest cavities and to test the effect of local climatic conditions on the sizes and orientations of these cavities in Aures cedar forests of north-eastern Algeria surveys were carried out in 2018 and 2019 breeding seasons using the point count method to search for the nests of the Levaillant’s Woodpecker. Based on measures realized on a total of 52 available nest cavities, results reveal entrances with a dominance of round shapes (94.2%) compared to oval shapes. The mean height and width values ​​of the cavity entrances were 7.26 ± 1.51 cm and 7.11 ± 1.44 cm. The depth of the internal chamber and its width were estimated at 35.42 ± 7.82 cm and 17.95 ± 4.01 cm respectively. Unlike the average values ​​of the volumes of the internal chamber, those relating to the entrance area and orientation vary significantly according to altitude and climatic conditions. Indeed, when climbing towards the summits, the cavities widen and turn to the west-southwest. This behavior of the Levaillant’s woodpecker seems to help it to benefit from maximum sunshine at high altitudes and to avoid predators and competitors more abundant at medium low altitudes.
hIgD-Fc-Ig fusion protein regulate T cell functions by inhibiting TCR signaling pathway in adjuvant arthritis rats
Authors: Zhang Xianzheng , Ge Jinru , Wang Pan , Xue Ziyang , Liu Ruijin , Zhang Tianjing , Hu Ling , Wang Han , Xu Li , Liang Faqin , Mei Dan , Yu Qianqian , Shu Jinling , ZHANG Ling-ling , Wei Wei 
Published: September 2022

Abstract
hIgD-Fc-Ig is a fusion protein that competes to bind IgD receptors, it remains unclear whether hIgD-Fc-Ig can regulate T cell function by regulating TCR signaling pathway in the treatment of adjuvant arthritis rats. In vivo, AA rats were treated with hIgD-Fc-Ig fusion protein and Etanercept for 28 days, then the overall indexes of AA rats, the severity of the pathology, the proliferation of spleen and thymus, the changes of blood flow signal in the knee joints as well as bone erosion of ankle joints were detected. Flow cytometry was used to detect the changes of peripheral blood and spleen T cell subsets. In vitro, rat spleen T cells or Jurkat cells were treated by IgD, and Lck inhibitor (PP1) and CD3ε siRNA were used to observe the function of IgD and hIgD-Fc-Ig on TCR and its downstream protein expression. The results showed that hIgD-Fc-Ig fusion protein had a obvious therputic effect on adjuvant arthritis rats, which could improve overall index, pathological status, the proportion of T cell subsets and other indicators. In addition, hIgD-Fc-Ig inhibited the expression of TCR and its downstream related proteins in rat spleen T cells or Jurkat cells. Which provided evidence that hIgD-Fc-Ig fusion protein could alleviate the symptoms of AA rats and regulate T cells through TCR-Lck-Erk signaling pathway. In a word, activated TCR signaling pathway leads to T cell activation which could be inhibited by hIgD-Fc-Ig fusion protein through regulating TCR signaling pathway. hIgD-Fc-Ig might be an immunomodulatory drug with anti-inflammatory effects.
Multi-parametric magnetic resonance imaging assessment of response to chemo-radiotherapy in tumors of glioma cell types: a prospective study
Authors: Zamanian Maryam , Abedi Iraj , Danazadeh Fatemeh , Amouheidari Alireza , Shahreza Bentolhoda Otroshi Otroshi 
Published: September 2022

Abstract
Purpose: Considering the high prevalence of glioma tumors and the limitation of approaches for assessing response to radiotherapy (RT), or chemo-RT (CRT), the aim of this study was to evaluate the use of quantitative magnetic resonance imaging methods along with the RANO criteria for patient follow-up.
Methods: Seventy-five patients with all types of glioma cell tumors including glioblastoma, oligodendroglia, ependymoma, and astrocytoma with definitive pathologic results were included in this prospective study. Contrast-enhanced lesion volume (CELV), non-enhanced lesion volume (NELV), necrotic tumor volume (NTV), and quantitative values of apparent diffusion coefficient (ADC) and magnetic resonance spectroscopy metabolites (Cho/Cr, Cho/NAA, NAA/Cr) was calculated by a neuroradiologist using a semi-automatic method. All patients were followed up and these values were recalculated one and six months after RT-CRT treatment.
Results: The results of the study showed statistically significant changes before and six months after RT-CRT for M-CELV in all glioma types (p<0.05). In all glioma cell types, the change in M-ADC, M-Cho/Cr, and Cho/NAA indices was incremental, and M-NAA/Cr decreased at six months. A significant difference was observed between diffusion indices changes, and metabolic ratios, and CELV changes in six months in all types (p<0.05). DWI/ADC indices had a higher mean percentage of sensitivity (98.25%) and specificity (96.57%).
Conclusion: The results of the present study showed that ADC and MRS indices can complement the commonly used methods to evaluate the response to CRT treatment of all types of glioma cells, although ADC has more sensitivity and specificity.
Morpho-nutritional status of micronutrient efficient wheat (Triticum aestivum L.) genotypes under changing environments
Authors: Sheera Ashish , Dey Tuhina , Aftab Nashra , Singh Tushadri , Pandey Mukesh Kumar , Kumar Bupesh , Dar Zafar Ali 
Published: September 2022

Abstract
In India, where cereal-based meals make up the majority of the daily diet, bread wheat (Triticum aestivum L.) is a key grain crop. Micronutrient deficiencies are a result of the lack of a diverse food culture in the nation. Genotypes of bread wheat that have been biofortified might be introduced to address this. It is anticipated that more information on the genotype x year interaction of these nutrients in grain will help us better understand the size of this interaction and perhaps even identify more stable genotypes for this attribute. Year revealed divergent responses to grain iron and zinc. Compared to zinc, iron showed lowest variation across year. Maximum temperature was the major determinant for the four traits. Iron is also significant correlation with zinc. Among the total fifty two genotype HP-06, HP-22, HP-24, HP-25, HP-33, HP-44 and HP-45 were found superior for Zinc and Iron content. This genotype with high levels of zinc and iron can be used in a hybridization programme to further crop improvement. Wide-scale cultivation of the chosen genotype with high zinc and iron content in the agro-climatic conditions of Jammu will work with the region's current cropping systems.
Variables associated with ovarian insufficiency in pediatric oncology patients following chemotherapy
Authors: Kaiser Kaydee M. , Rao Pooja , Estes Stephanie J. 
Published: September 2022

Abstract
Purpose
Gonadotoxic effects of chemotherapy is a critical concern in Pediatric Oncology given most patients survive their cancer. Future fertility is an important concern in this population supporting the need for additional research on chemotherapy gonadotoxicity. This study’s purpose was to identify associations with premature ovarian insufficiency (POI) in pediatric patients with a history of cancer based on age, cancer type and cyclophosphamide equivalent dose (CED).
Methods
We retrospectively collected data on pediatric patients with cancer treated between 2008–2017. Inclusion criteria included female gender, age 0–25 at time of cancer diagnosis, diagnosis of a malignancy requiring chemotherapy, and documented ovarian hormone levels following chemotherapy completion.
Results
Two-hundred and forty-five female patients were identified based on age, malignancy and chemotherapy criteria.. Of these, 57 had documented ovarian hormone levels following chemotherapy. Five patients (9%) met criteria for POI. These 5 patients were all ≥ 13 years old at time of cancer diagnosis and found to have a lymphoma or solid tumor diagnosis.
Conclusion
We sought to analyze ovarian hormone levels for pediatric cancer survivors based on age in which chemotherapy was administered. There was a significant association between POI and age ≥ 13 years at time of cancer diagnosis. Those documented with POI received a CED between 0-28.4 gm/m2, suggesting other factors contribute to ovarian dysfunction.
Implications for cancer survivors
As more pediatric patients are being cured of their cancer diagnoses, gonadal health and treatment-related risks continue to be important topics of research to help provide informed gonadal-preservation conversations in this vulnerable population.
Effects of curing temperature and water glass modulus on the preparation of hierarchical zeolite precursors
Authors: Zhou Lianzhu , Wang Anhu , Li Hong , Zhou Wenwen , Wang Jiaqing , Luo Yang , qian Binbin , Liang Ruihuan , Gao Huan , Li Yanbo , Ye Jiayuan , Hu Yueyang 
Published: September 2022

Abstract
The hierarchical design of zeolite materials from alkali-activated solid waste is a controversial topic. Deactivated ZSM-5 can serve as a potential foaming material for the preparation of porous zeolite precursors. This article evaluated the suitability of deactivated ZSM-5 for the preparation of porous zeolite material precursors. Curing temperature and water glass modulus were selected to regulate the properties of alkali-activated cementitious material. Two different moduli of water glass (1.4 M and 2.0 M) were applied to determine the effect of samples cured at three temperatures (25 ℃, 50 ℃ and 75 ℃). Characterization analyses such as XRD, FTIR, TG/DTA, SEM/EDS and MIP were performed to analyse the final products and pore structure of the precursors. A higher curing temperature and alkalinity have a substantial influence on the mechanical properties and yield a higher degree of polymerization of the reaction products. The main reaction product in the precursors was the N-A-S-H gel, whose degree of polymerization is strongly influenced by the Si/Al ratio. The purpose of this article is to design porous structures for zeolite precursors. The research results provide promising guidance for the preparation of zeolites with more active sites, high strength and porous structures that are self-supported.
IL6 stromal expression is correlated with epithelial–mesenchymal transition at tumor budding in colorectal cancer
Authors: Uehara Takeshi , Sato Koichi , Iwaya Mai , Asaka Shiho , Nakajima Tomoyuki , Tobe Yosuke , Nagaya Tadanobu , Kitazawa Masato , Ota Hiroyoshi 
Published: September 2022

Abstract
Background: Tumor budding (TB) is a poor prognostic factor in colorectal adenocarcinoma (CA), but the underlying mechanism remains unclear. Interleukin-6 (IL6) is one of the main cytokines produced by cancer-associated fibroblasts. IL6 is linked with cancer progression and poor prognosis by activating cancer cells and modifying the cancer microenvironment. However, little is known about the expression of IL6 in TB and its association with TB in CA.
Methods: The clinicopathological and prognostic significance of IL6 in TB was examined using a tissue microarray consisting of 36 patient samples of TB in CA. IL6 mRNA was detected by RNAscope. Patients were stratified into negative and positive IL6 expression groups.
Results: IL6 expression was overwhelmingly observed in cancer stroma but was negligible in cancer cells. In the IL6-positive group in cancer stroma, TB grade was higher than in the IL6-negative group (P=0.0161). The IL6-positive group significantly exhibited the epithelial–mesenchymal transition (EMT) phenotype compared with the IL6-negative group in cancer stroma (P=0.0301). There was no significant difference in overall survival between CA cases in the IL6-positive and -negative groups in cancer stroma.
Conclusions: TB may be affected by IL6 expression, and IL6expression in cancer stroma at TB may be an important prognostic marker.
Sediment microbial community structure, enzymatic activities and functional gene abundance in the coastal hypersaline habitats
Authors: Chaudhary Doongar , Kumar Madhav , Kalla Vandana 
Published: September 2022

Abstract

Salt marsh vegetation, mudflat and salt production are common features in worldwide coastal areas; however, their influence on microbial community composition and structure has been poorly studied and rarely compared. In the present study, microbial community composition (phospholipid fatty acid (PLFA) profiling and 16S rRNA gene sequencing (bacterial and archaeal)), enzymatic activities and abundance of functional genes in the sediments of salt ponds (crystallizer, condenser and reservoir), mudflat and vegetated mudflat were determined. Physicochemical characteristics of the sediments were also studied. Enzyme activities (β-glucosidase, urease and alkaline phosphatase) were considerably decreased in saltpan sediments because of elevated salinity while sediment of vegetated mudflat showed the highest enzyme activities. Concentrations of total and microbial biomarker PLFAs (total bacterial, Gram-positive, Gram-negative, fungal and actinomycetes) were the highest in vegetated mudflat sediments and the lowest in crystallizer sediments. Nonmetric-multidimensional scaling (NMS) analysis of PLFA data revealed that the microbial community of crystallizer, mudflat and vegetated mudflat was significantly different from each other as well as different from condenser and reservoir. The most predominant phyla within the classified bacterial fractions were Proteobacteria followed by Firmicutes, Bacteroidetes and Planctomycetes, while Euryarchaeota and Crenarchaeota phyla dominated the classified archaeal fraction. Cyanobacterial genotypes were the most dominant in the condenser. Mudflat and vegetated mudflat supported a greater abundance of Bacteroidetes and Actinobacteria, respectively. The results of the present study suggest that salt ponds had significantly decreased the microbial and enzyme activities in comparison to mudflat and vegetated mudflat sediments due to very high salinity, ionic concentrations and devoid of vegetation.
Deciphering the molecular insight behind the inhibitory role of copper and silver nanocomposite on important bacterial and fungal pathogens in rice (oryza sativa)
Authors: Chowdhury Arnab Roy , Kumar Rishikesh , Mahanty Arabinda , Mukherjee Koel , Kumar Sudhir , Tribhuvan Kishor U. , Sheel Rishav , Lenka Srikanta , Singh Binay K. , Chattopadhyay Chirantan , Sharma T. R. , Bhadana Vijai Pal , Sarkar Biplab 
Published: September 2022

Abstract
Rice (Oryza sativa) being among the most important food crops in the world is also susceptible to various bacterial and fungal diseases that are the major stumbling blocks in the way of increased production and productivity. The bacterial leaf blight caused by Xanthomonas oryzae pv. oryzae and the sheath blight disease caused by Rhizoctonia solani are among the most devastating diseases of the rice crop. In spite of the availability of array of chemical control, there are chances of development of resistance. Thus, there is a need for the nanotechnological intervention for management of disease in the form of copper and silver nano-composites. The copper and silver nanoparticles were synthesized and characterized using different high throughput techniques, i.e., UV-Vis, FT-IR, DLS, XRD, FE-SEM, TEM. The characterization results confirmed the formation of copper and silver nanoparticles. The copper and silver nanoparticle composites evaluated against Xanthomonas oryzae pv. oryzae and Rhizoctonia solani were found to have higher antibacterial and antifungal activities compared to only the copper nanoparticle. Net house trials of nano-composite formulations against the bacterial blight of rice also corroborated the potential of nanocomposite formulation. In silico studies were carried out selecting two disease-causing proteins, peptide deformylase (Xanthomonas oryzae) and pectate lyase (Rhizoctonia solani) to perform the molecular docking and interaction studies with silver and copper nanoparticles. These proteins could be the potential targets of the nanoparticles. The study suggested that the copper and silver nano-composites could be used for developing formulations to control these devastating rice diseases.
Reporting of rapid diagnostic testing in Kenya's health system, 2018-2020: triangulation of routine and survey data
Authors: Moturi Angela K , Robert Bibian N , Bahati Felix , Macharia Peter M , Okiro Emelda A 
Published: September 2022

Abstract

Background Understanding access to and availability of rapid diagnostic tests (RDTs) is essential for attaining universal health care and reducing health inequalities. Although routine data helps measure RDT coverage and health access gaps, a significant proportion of healthcare facilities fail to report their monthly diagnostic test data to routine health systems, which affects routine data quality. This study sought to understand whether non-reporting by facilities is due to a lack of diagnostic and service provision capacity by triangulating routine and survey data in Kenya. Methods Monthly facility-level data on ten RDTs (malaria, HIV, syphilis, blood transfusion, anaemia, diabetes, pregnancy, urinary tract infections, kidney disease, and meningitis) was sourced from Kenya's health information system (2018–2020), and 2018 harmonised health facility assessment. After harmonization and linking the two data sources, we compared reporting in the routine system among facilities with i) diagnostic capacity only and ii) both confirmed diagnostic capacity and service provision. We also assessed trends in reporting for facilities without diagnostic capacity. Analyses were conducted at the national level, disaggregated by RDT, facility level and ownership. Results Twenty-one per cent (2821) of all facilities expected to report routine diagnostic data in Kenya were included in the triangulation. Majority (86%) were primary-level facilities under public ownership (70%). Overall, survey response rates across facilities were high (> 70%). Malaria and HIV had the highest response rate (> 96%) as well as the broadest coverage in diagnostic capacity across facilities (> 76%). Reporting among facilities with diagnostic capacity varied by test, with HIV and malaria having the lowest reporting rates, 58% and 52%, respectively, while the rest ranged between 69% and 85%. Among facilities with both service provision and diagnostic capacity, reporting ranged between 52% and 83% across common tests. Public and secondary facilities had the highest reporting rates across all tests. A small proportion of health facilities without diagnostic capacity submitted testing reports in 2018, most of which were primary facilities. Conclusion Non-reporting in routine health systems is not always due to a lack of capacity. Further analyses are required to inform other drivers of non-reporting to ensure reliable routine health data.
Floriculture Crop Production in the United States1
Authors: Seeley John G. , Langhans Robert W. 
Published: September 2022

Abstract
Ornamental horticulture is concerned with the cultivation, production and use of plants and flowers for enhancement of the environment indoors as well as outdoors, where well planned landscape plantings not only improve the environment but also add to the esthetic and functional value of the area. In the U.S., the term commercial floriculture crop production applies to cut flowers, potted flowering and foliage plants, and bedding plants produced in heated glass or plastic structures, or out of doors.
Delay of Senescence in Carnations by a Rhizobitoxine Analog and Sodium Benzoate1
Authors: Baker James E. , Wang Chien Yi , Lieberman Morris , Hardenburg Robert 
Published: September 2022

Abstract
The rhizobitoxine analog, L-2-amino-4-(2-aminoethoxy)-trans-3-butenoic acid, and sodium benzoate inhibited ethylene production in cut flowers of carnation (Dianthus caryophyllus, L. cv. White Sim) and extended the vase life by several days. The rhizobitoxine analog (Ro) and sodium benzoate were added to a basal holding solution of 2% sucrose, 0.02% 8-hydroxyquinoline citrate, and 0.02 M potassium citrate buffer (pH 4.7). The results indicate that Ro at 0.068 mM increased the vase life of cut carnations by 95% or more. Sodium benzoate at 1.0 or 2.0 mM also increased the vase life. The compounds may have increased vase life of the flowers by inhibiting ethylene production. The effects of these compounds were over and above the effects of sucrose, 8-hydroxyquinoline citrate, and acid pH of the holding solution.
Rooting of Hibiscus rosa-sinensis L. Cuttings as Influenced by Light Intensity and Ethephon1
Authors: Johnson C. R. , Hamilton D. F. 
Published: September 2022

Abstract
After 48 days rooting percentages and quality were highest for cuttings from Hibiscus rosa-sinensis plants grown under a reduced light intensity (65% natural light) regardless of (2-chloroethyl)phosphonic acid (ethephon) sprays at 100-5,000 ppm or indolebutyric acid (IBA) treatment to cuttings (0.8%). Ethephon and IBA treatments only affected cuttings from plants grown in 100% natural light, but rooting was not superior to that of cuttings from plants grown under reduced light. After 62 days, there were no treatment differences.