bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postmortem Human Dura Mater Cells Exhibit Phenotypic, Transcriptomic and Genetic Abnormalities that Impact their Use for Disease Modeling
Authors: Argouarch Andrea R. , Schultz Nina , Yang Andrew C. , Jang Yeongjun , Garcia Kristle , Cosme Celica G. , Corrales Christian I. , Nana Alissa L. , Karydas Anna M. , Spina Salvatore , Grinberg Lea T. , Miller Bruce , Wyss-Coray Tony , Abyzov Alexej , Goodarzi Hani , Seeley William W. , Kao Aimee W. 
Published: July 2022

AbstractPatient-derived cells hold great promise for precision medicine approaches in human health. Human dermal fibroblasts have been a major source of cells for reprogramming and differentiating into specific cell types for disease modeling. Postmortem human dura mater has been suggested as a primary source of fibroblasts for in vitro modeling of neurodegenerative diseases. Although fibroblast-like cells from human and mouse dura mater have been previously described, their utility for reprogramming and direct differentiation protocols has not been fully established. In this study, cells derived from postmortem dura mater are directly compared to those from dermal biopsies of living subjects. In two instances, we have isolated and compared dermal and dural cell lines from the same subject. Notably, striking differences were observed between cells of dermal and dural origin. Compared to dermal fibroblasts, postmortem dura mater-derived cells demonstrated different morphology, slower growth rates, and a higher rate of karyotype abnormality. Dura mater-derived cells also failed to express fibroblast protein markers. When dermal fibroblasts and dura mater-derived cells from the same subject were compared, they exhibited highly divergent gene expression profiles that suggest dura mater cells originated from a mixed mural lineage. Given their postmortem origin, somatic mutation signatures of dura mater-derived cells were assessed and suggest defective DNA damage repair. This study argues for rigorous karyotyping of postmortem derived cell lines and highlights limitations of postmortem human dura mater-derived cells for modeling normal biology or disease-associated pathobiology.
Graphical abstract
Developing design principles to standardize e-commerce ecosystems
Authors: Wulfert Tobias , Woroch Robert , Strobel Gero , Seufert Sarah , Möller Frederik 
Published: July 2022

AbstractPlatform ecosystems have captured a variety of markets, enabling coordination, transactions, and value co-creation between independent actors. A focal platform constitutes the central nexus of e-commerce ecosystems and fosters the interaction among ecosystem participants through their boundary resources. Standardizing these interfaces simplifies ecosystem entry for developers and increases the number of participants propelling the network effects, and thus the overall value of the ecosystem. Currently, there is a lack of prescriptive design knowledge guiding platform owners in designing successful e-commerce ecosystems. Addressing this issue, we followed a dual approach, reporting on a systematic literature review in which we identified design requirements and complemented these with a multiple-case study on selected e-commerce ecosystems. Aggregating the requirements resulted in six meta-requirements and 19 design principles that foster the standardization of focal e-commerce platforms. Our design principles simplify the development of complements and enable multi-homing for developers due to possible standardization across ecosystems.
Survival and long-term surgical outcomes after colorectal surgery: are there any gender-related differences?
Authors: Losurdo Pasquale , Mastronardi Manuela , de Manzini Nicolò , Bortul Marina 
Published: July 2022

AbstractColorectal cancer (CRC) incidence and mortality seems to be lower in women than in men. The present study aims to evaluate the impact of gender on CRC diagnosis, treatment, and survival. This is a retrospective cohort study based on a single-center dataset of CRC patients from the University Hospital of Trieste (Italy). Data of 1796 consecutive CRC patients referred to our center from November 11th, 2004, to December 31st, 2017, were analyzed. Right-sided carcinomas are more frequent in women than in men; furthermore, women had a lower surgical complication rate. Men showed a higher 5- and 10-year mortality. This survival benefit for women was observed independently of the tumor localization. The 5-year hazard ratio (HR) for women vs men was 0.776 (p 0.003), and after 10-year 0.816 (p 0.017). Regarding the disease-free survival (DFS), 5 and 10-year HR was 0.759 (p 0.034) and 0.788 (p 0.07), respectively. On multivariable analysis, respecting tumor localization, the odds of female gender were higher than man with right colon disease. Male gender was more independently associated with age at the surgery time. Women survival advantage was higher than men, except for patients older than 80. Surgical outcome and survival after CRC surgical treatment seem to be gender related. For this reason, gender could play an important role in CRC diagnosis and therapy, allowing an earlier diagnosis in women.
Experimental Study on Vortex-Induced Vibration Coupling Wake Interference of Multi-Riser Groups with Sensitive Spacing
Authors: Wang Yu , Li Peng , Liu Yu , Chen Xin , Lou Min , Guo Hai-yan 
Published: July 2022

AbstractThe “riser group—fluid between risers” is taken as the carrier, and the experiment on vortex-induced vibration of tandem riser groups coupling interference effect under sensitive spacing is performed. The least-square method is used to linearly fit the reduced velocity and main frequency, and the rule of Strouhal numbers is analyzed. Each mode is separated based on the mode decomposition theory, and the mode conversion mechanism is also explored. The concept of “interference efficiency” is introduced to study the dynamic characteristics and response evolutions of different riser groups. The results show that the wake shielding effect widely exists in tandem riser groups, and the interference effect of midstream and downstream risers on their upstream risers is significantly lower than that of upstream risers on midstream and downstream risers. The trajectories of midstream and downstream risers lag behind their upstream risers due to multiple shadowing effects, the vibration frequency range of downstream riser is widened and the dominant frequency is extremely unstable. Compared with the isolated riser, wake interference suppresses the vibration displacement of the midstream and downstream risers in the in-line direction, and enhances the displacement of upstream and midstream risers in the cross-flow direction. The interference effect of the fluid between risers at low velocities is stronger than that at higher velocities, and the cross-flow displacements of upstream risers are always in the interference enhancement region. It is urgent to pay attention to the cross-flow displacement of upstream and midstream risers in tandem riser groups considering the safety design.
Effect of SRA-programming on computational thinking through different output modalities
Authors: Fanchamps Nardie , Slangen Lou , Specht Marcus , Hennissen Paul 
Published: July 2022

AbstractThe application of sense-reason-act (SRA) programming in contemporary education can ensure the development of computational thinking (CT) at a more advanced level. SRA-programming has been identified as an instrumental way of thinking for learning to program robots and encourages the development of the more complex concepts of programming. Visual programming environments are diverse in appearance and prove to be an excellent way to teach pupils the basic ideas of programming. It is important to investigate whether the type of output has a characteristic influence on the level of development of CT in visual programming environments. In this research, we therefore explore whether characteristic differences in the development of CT can be measured when SRA-programming is applied in a visual programming environment with an on-screen output or a tangible output. It was expected that the observed effect of pupils' programming actions through the application of SRA would show that the type of output influences the understanding of complex programming concepts at a higher level. Our results indicate that SRA-programming with visual, on-screen output yields a significant increase in the development of CT, as opposed to SRA-programming with a tangible output. The development of complex programming concepts can also be demonstrated.
Tailoring Nitrogen Terminals on MXene Enables Fast Charging and Stable Cycling Na-Ion Batteries at Low Temperature
Authors: Xia Yang , Que Lanfang , Yu Fuda , Deng Liang , Liang Zhenjin , Jiang Yunshan , Sun Meiyan , Zhao Lei , Wang Zhenbo 
Published: July 2022

AbstractSodium-ion batteries stand a chance of enabling fast charging ability and long lifespan while operating at low temperature (low-T). However, sluggish kinetics and aggravated dendrites present two major challenges for anodes to achieve the goal at low-T. Herein, we propose an interlayer confined strategy for tailoring nitrogen terminals on Ti3C2 MXene (Ti3C2-Nfunct) to address these issues. The introduction of nitrogen terminals endows Ti3C2-Nfunct with large interlayer space and charge redistribution, improved conductivity and sufficient adsorption sites for Na+, which improves the possibility of Ti3C2 for accommodating more Na atoms, further enhancing the Na+ storage capability of Ti3C2. As revealed, Ti3C2-Nfunct not only possesses a lower Na-ion diffusion energy barrier and charge transfer activation energy, but also exhibits Na+-solvent co-intercalation behavior to circumvent a high de-solvation energy barrier at low-T. Besides, the solid electrolyte interface dominated by inorganic compounds is more beneficial for the Na+ transfer at the electrode/electrolyte interface. Compared with of the unmodified sample, Ti3C2-Nfunct exhibits a twofold capacity (201 mAh g−1), fast-charging ability (18 min at 80% capacity retention), and great superiority in cycle life (80.9%@5000 cycles) at − 25 °C. When coupling with Na3V2(PO4)2F3 cathode, the Ti3C2-Nfunct//NVPF exhibits high energy density and cycle stability at − 25 °C."Image missing"
Microstructure Design of High-Entropy Alloys Through a Multistage Mechanical Alloying Strategy for Temperature-Stable Megahertz Electromagnetic Absorption
Authors: Liu Xiaoji , Duan Yuping , Guo Yuan , Pang Huifang , Li Zerui , Sun Xingyang , Wang Tongmin 
Published: July 2022

AbstractDeveloping megahertz (MHz) electromagnetic wave (EMW) absorption materials with broadband absorption, multi-temperature adaptability, and facile preparation method remains a challenge. Herein, nanocrystalline FeCoNiCr0.4Cu0.2 high-entropy alloy powders (HEAs) with both large aspect ratios and thin intergranular amorphous layers are constructed by a multistage mechanical alloying strategy, aiming to achieve excellent and temperature-stable permeability and EMW absorption. A single-phase face-centered cubic structure with good ductility and high crystallinity is obtained as wet milling precursors, via precisely controlling dry milling time. Then, HEAs are flattened to improve aspect ratios by synergistically regulating wet milling time. FeCoNiCr0.4Cu0.2 HEAs with dry milling 20 h and wet milling 5 h (D20) exhibit higher and more stable permeability because of larger aspect ratios and thinner intergranular amorphous layers. The maximum reflection loss (RL) of D20/SiO2 composites is greater than − 7 dB with 5 mm thickness, and EMW absorption bandwidth (RL < − 7 dB) can maintain between 523 and 600 MHz from − 50 to 150 °C. Furthermore, relying on the “cocktail effect” of HEAs, D20 sample also exhibits excellent corrosion resistance and high Curie temperature. This work provides a facile and tunable strategy to design MHz electromagnetic absorbers with temperature stability, broadband, and resistance to harsh environments.
Securing future healthcare environments in a post-COVID-19 world: moving from frameworks to prototypes
Authors: Vithanwattana Nattaruedee , Karthick Gayathri , Mapp Glenford , George Carlisle , Samuels Ann 
Published: July 2022

AbstractThe deployment of Internet of Things platforms as well as the use of mobile and wireless technologies to support healthcare environments have enormous potential to transform healthcare. This has also led to a desire to make eHealth and mHealth part of national healthcare systems. The COVID-19 pandemic has accelerated the requirement to do this to reduce the number of patients needing to attend hospitals and General Practitioner surgeries. This direction, however, has resulted in a renewed need to look at security of future healthcare platforms including information and data security as well as network and cyber-physical security. There have been security frameworks that were developed to address such issues. However, it is necessary to develop a security framework with a combination of security mechanisms that can be used to provide all the essential security requirements for healthcare systems. In addition, there is now a need to move from frameworks to prototypes which is the focus of this paper. Several security frameworks for eHealth and mHealth are first examined. This leads to a new reference model from which an implementation framework is developed using new mechanisms such as Capabilities, Secure Remote Procedure Calls, and a Service Management Framework. The prototype is then evaluated against practical security requirements.
Moduli-friendly Eisenstein series over the p-adics and the computation of modular Galois representations
Authors: Mascot Nicolas 
Published: July 2022

AbstractWe show how our p-adic method to compute Galois representations occurring in the torsion of Jacobians of algebraic curves can be adapted to modular curves. The main ingredient is the use of “moduli-friendly” Eisenstein series introduced by Makdisi, which allow us to evaluate modular forms at p-adic points of modular curves and dispenses us of the need for equations of modular curves and for q-expansion computations in the construction of models of modular Jacobians. The resulting algorithm compares very favourably to our complex-analytic method.
Managing groundwater resources using a national reference database: the French ADES concept
Authors: Winckel Anne , Ollagnier Stéphane , Gabillard Santiago 
Published: July 2022

Abstract
Groundwater is an integral part of the water cycle and an essential human resource. Humans must protect this ever-changing heritage and preserve it in a sustainable way by understanding the physical and chemical properties of aquifers and monitoring their quantity and quality. Numerous studies have collected immense volumes of data that are difficult to access and not always comparable or of adequate quality. A pioneering national-scale database, ADES, was created in 1999 to store and make available quality data on French groundwater. This tool is freely accessible for/to water managers, scientists and the public. The data management system used in the database satisfies two important objectives: it is interoperable and based on a recognised groundwater reference system and provides high quality data to a large public. Data from different producers require normalisation and standardisation of system requirements to allow data integration and exchange. The database designers set up shared data models, and based the system on communal repositories of water points and hydrogeological entities. Nearly 102 million groundwater quality records and over 17 million water-level records are currently available, describing almost 61,800 stations. ADES makes it possible to visualise in “real-time" water level data for approximately 1500 stations equipped with GPRS (General Packet Radio Service) technology. ADES also provides, on a public website and via web services, public quantitative and qualitative data. ADES is an essential tool for developing groundwater services based on the FAIR guiding principles: Findable, Accessible, Interoperable and Reusable data (Wilkinson et al. in SD 3:160018, 2016)

Article highlights

A unique database for storing and disseminating reliable, comprehensive, and up-to-date
groundwater data to a large public.

An interoperable system based on a common reference system to ensure data reliability.

An interoperable system based on a common reference system to ensure data reliability.
Petrology of the meta-mafic rocks from the Lolodorf area, Nyong complex (Southwest Cameroon): implication for the origin and emplacement conditions
Authors: Messi Ottou Eric José , Ntomba Sylvestre Martial , Ntieche Benjamin , Magnekou Takamte Rufine Christelle , Bisse Salomon Bertrant , Ndong Bidzang François , Mvondo Ondoa Joseph 
Published: July 2022

AbstractThis study presents the new petrology and geochemistry data for the comprehension of the origin and emplacement conditions of the Lolodorf mafic rocks whitin the Nyong Complex. The meta-mafic rocks consist of fine-grained garnet meta-mafic (FGM) and coarse-grained garnet meta-mafic (CGM) rocks presenting nearly similar mineral composition. They are made up of quartz, plagioclase, garnet orthopyroxene, clinopyroxene, amphibole, opaques, apatite and rutile. They also present recrystallization features such as quartz ribbons, corroded grain mineral, cuspate plagioclase boundary and necklace garnets in the matrix. These mineral assemblages suggest that the recrystallization took place under granulite facies condition. The meta-mafic rocks have basaltic and tholeiitic composition like the magmas (SiO2 FGM = 48.20–50.70 wt% and SiO2CGM = 46.68–50.27 wt% and MgFGM = 43.24–62.27 and MgCGM = 40.85–69.70) emplaced in the active continental margin context. The low La/Th ratio observed in the FGM and the high La/Th ratio in the CGM together with low Hf content imply that the FGM are reworked plutonic rocks that recorded both high grade partial melting and metamorphism whereas CGM recorded only metamorphism imprints. Thermobarometry results suggest that the partial melting and metamorphic peak occurred around the amphibolite-granulite facies transition. The fine-grained garnet meta-mafic rocks emplaced under pressure estimated at around 2.7–14.89 kbar with temperature interval between 672 and 952 °C while the coarse-grained garnet meta-mafics settled at around 1.5–16.09 kbar and 631–909 °C. The selected amphiboles display low water content (1.92–2.10 wt%) and plot between NNO and NNO + 2 buffers indicating that they crystallized under high oxidizing conditions. These results coupled with previous geochronological study suggest that the FGM may have occurred at the Mesoarchean and have been reworked during Eburnean whereas the CGM may have been formed at the Eburnean.
Combining earth sciences with archaeology to investigate natural risks related to the cultural heritage of the Marsica region (central Apennines, Italy)
Authors: Galadini Fabrizio , Ceccaroni Emanuela , Dixit Dominus Girolamo , Falcucci Emanuela , Gori Stefano , Maceroni Deborah , Bonasera Mauro , Di Giulio Giuseppe , Moro Marco , Saroli Michele , Vassallo Maurizio 
Published: July 2022

AbstractMethods of Earth Sciences have been employed in archaeological sites of the Marsica region, central Italy, in two different perspectives: to enhance knowledge on past natural events which damaged/destroyed ancient settlements/monuments and to gather data useful/necessary for preservation of the local cultural heritage. Within this wide perspective, the paper deals with (i) recent archaeoseismological investigations at Alba Fucens and other sites of the Fucino Plain which add evidence of sudden building collapse to the already available (archaeoseismological and paleoseismological) data concerning seismicity of fifth-sixth century AD; (ii) archaeological investigations on remains of the Medieval church of San Bartolomeo showing that coseismic damage in 1349 caused the abandonment of part of the building and its (re)use for burials; (iii) evidence of slope instability which caused rapid mass deposition in the lowest sector of ancient Alba Fucens since around the half of the sixth century AD, inhibiting the occupation of the Roman town; (iv) capable faulting potentially affecting the westernmost sector of the huge hydraulic works made by Romans during the first-second century AD to drain former Lake Fucino.
Validity of sagittal thoracolumbar curvature measurement using a non-radiographic surface topography method
Authors: Hannink Erin , Dawes Helen , Shannon Thomas M. L. , Barker Karen L. 
Published: July 2022

Abstract
Purpose
To estimate the criterion validity of sagittal thoracolumbar spine measurement using a surface topography method in a clinical population against the gold standard and to estimate concurrent validity against two non-radiographic clinical tools.

Methods
In this cross-sectional validity study, thoracolumbar curvature was measured in adults with spinal conditions recruited from a specialist orthopaedic hospital. A surface topography method using a Kinect sensor was compared to three other measurement methods: spinal radiograph (gold standard), flexicurve and digital inclinometer. Correlation coefficients and agreement between the measurement tools were analysed.

Results
Twenty-nine participants (79% female) were included in criterion validity analyses and 38 (76% female) in concurrent validity analyses. The surface topography method was moderately correlated with the radiograph (r = .70, p < .001) in the thoracic spine, yet there was no significant correlation with the radiograph in the lumbar spine (r = .32, p = .89). The surface topography method was highly correlated with the flexicurve (rs = .91, p < .001) and digital inclinometer (r = .82, p < .001) in the thoracic spine, and highly correlated with the flexicurve (r = .74, p < .001) and digital inclinometer (r = .74, p < .001) in the lumbar spine.

Conclusions
The surface topography method showed moderate correlation and agreement in thoracic spine with the radiograph (criterion validity) and high correlation with the flexicurve and digital inclinometer (concurrent validity). Compared with other non-radiographic tools, this surface topography method displayed similar criterion validity for kyphosis curvature measurement.
Radiated seismic energy from the 2021 ML 5.8 and ML 6.2 Shoufeng (Hualien), Taiwan, earthquakes and their aftershocks
Authors: Hwang Ruey-Der , Huang Yi-Ling , Chang Wen-Yen , Lin Cai-Yi , Lin Chiung-Yao , Wang Sheng-Tung , Chan Jing-Bei , Chang Jo-Pan , Lin Tzu-Wei 
Published: July 2022

AbstractWe calculated radiated seismic energy (ES), seismic moment (M0), and moment magnitude (MW) and then determined the ES–ML, ES–M0, M0–ML, and MW–MLrelations for the 2021 Shoufeng earthquake sequence (2.5 < ML < 6.3), where MLis the local magnitude. Notably, a crossover magnitude was detected as ML = 4.0 for the earthquake sequence. For ML < 4.0, we obtained logM0 ∝ ML, MW ∝ 0.67ML, and a low ES/M0, indicating a low average stress drop; for ML > 4.0, logM0 ∝ 0.67ML, MW ∝ ML, and a high ES/M0were present, and then there was a high average stress drop. These derived relations implied that source duration (T) is independent of M0for ML < 4.0. Moreover, the M0 ∝ T3relation seemed able to interpret those relations for ML > 4.0. Nevertheless, the ES–MLrelation remains logES ∝ 2.0MLfor 2.5 < ML < 6.3. From this study, the derived relations could not predict the source parameters for ML > 6.3 events. This might indicate that MLsaturates beyond ML6.3. Through such analyses, we not only established the relations among source parameters but also elucidated the basic physics of the earthquake sequence.