bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermocoagulation for the Treatment of Anorexia Nervosa Associated with Obsessive-Compulsive Disorder: Case Report
Authors: Sarkis Cristiano Mendonça , Amaral Jordana Gonçalves de Miranda , Silva Ledismar José da 
Published: August 2022

AbstractAnorexia nervosa (AN) and obsessive-compulsive disorder (OCD) are two psychiatric disorders that often overlap or are diagnosed as distinct disorders in the same individual. Although neurosurgical treatment is currently reserved for patients with refractory chronic OCD, it has been evidenced that it is also effective for the treatment of AN, since these two disorders share some pathophysiological neurocircuits. The present study aimed to report the case of a patient with AN, OCD, schizophrenia, and comorbid depression who underwent thermocoagulation of the nucleus accumbens associated with anterior cingulotomy and anterior capsulotomy, all of them bilaterally. Follow-up, performed 16 months after the procedure, showed substantial improvement in AN, OCD, and schizophrenia symptoms, demonstrating the effectiveness of this type of intervention in patients refractory to conservative treatment.
Effect of Intramuscular Injection of Vitamin D on 25-Hydroxyvitamin D Levels, Glycaemic Control, and Liver Enzymes in Libyan Patients with Type 2 Diabetes Mellitus
Authors: Alemam Hafsa M. , ElJilani Mouna M. , Bashein Abdulla M. 
Published: August 2022

Background Vitamin D is a fat-soluble hormone that plays an important role in glycaemic control. In addition, it has a positive effect on improving liver enzyme function.
Aim This study was performed to examine the effect of intramuscular injection of vitamin D on serum 25-hydroxyvitamin D [25(OH)D] levels, glycemic control, and liver enzymes in Libyan patients suffering from type 2 diabetes mellitus (T2DM) with vitamin D deficiency.
Methods and Materials This cross-sectional study enrolled 100 T2DM (50 males and 50 females). Their serum 25(OH)D, fasting blood glucose (FBG), and liver enzymes were measured at the baseline and 12 weeks after treatment with vitamin D (200,000 IU) injection monthly for 3 months. Data analysis involved the estimation of mean ± standard error (SE) and comparison of means between pre and post-treatment values using paired t-test. Independent t-test was used to compare the means between males and females. The level of significance was set at p < 0.05.
Results Females had a lower 25(OH)D blood levels than males at baseline (7.03 ± 0.25 ng/mL versus 7.86 ± 0.26 ng/mL, respectively p < 0.02). 25(OH)D levels in both sexes was increased significantly from 7.45 ± 0.18 ng/mL to 26.69 ± 0.24 ng/mL after 12 weeks of vitamin D injections (p < 0.001), with no significant differences between male and females. FBG levels in both sexes was significantly decreased from 144.68 ± 1.84 mg/dL to 85.96 ± 0.34 mg/dL post treatment (p < 0.001). Alanine aminotransferase (ALT) was increased from 10.24 ± 0.17 U/L at baseline to 20.34 ± 1.15 U/L post treatment (p < 0.001). Similarly, aspartate aminotransferase (AST) was increased from 11.23 ± 0.21 to 20.57 ± 0.22 U/L (p < 0.001), and alkaline phosphatase (ALP) was decreased from 124.95 ± 1.15 U/L to 111.17 ± 1.27 U/L (p < 0.001). There were no significant differences between male and female liver enzymes either pre- or post-vitamin D injections
Conclusion Treatment with vitamin D injection showed a significant increase in 25(OH)D accompanied by decreased FBG and ALP levels and increased ALT and AST levels. Vitamin D levels should be monitored and adjusted in diabetic patients.
Evaluation of Bone Metabolism in Children Using Antiseizure Drugs: A Single-Center Experience and Review of the Literature
Authors: Tekin Emine , Gül Ülkü Şiraz , Aydın Sultan Köker , Köksoy Adem Yasin 
Published: August 2022

AbstractThe effect of anti-seizure drugs (ASDs) on bone mineral density (BMD) is a controversial topic. This study investigated the effect of monotherapy and polytherapy drugs separately. Patients with a history of epilepsy treated with the same ASDs for more than 6 months were included in the study. Data regarding patient demographics, biochemical markers related to bone metabolism (calcium, phosphorus, alkaline phosphatase, parathyroid hormone, vitamin D), and BMD with dual-energy X-ray absorptiometry (DXA) were collected and compared. In total, 104 children with epilepsy using valproic acid (VPA), levetiracetam (LEV), carbamazepine (CBZ) alone or in combination and 22 healthy controls were evaluated. The ages of the children (64 boys, 62 girls) ranged between 2 and 17, with a mean of 9.50 ± 4.03 years. BMD or Z-scores did not differ among the monotherapy groups or between them and the polytherapy group. The lowest mean Z-score was in the VPA group but without statistical significance. Alkaline phosphatase levels were significantly higher in the group using CBZ. Calcium levels significantly differed between the groups (p = 0.001). The CBZ and LEV groups had the lowest calcium levels. However, phosphorus and vitamin D measurements did not significantly differ by ASDs used. Unfortunately, low vitamin D levels were evident in all children with epilepsy and even among controls. Physical activity, sun exposure, and calcium intake might be recommended in children treated with ACDs and in combination with additional risk factors monitoring via DXA should be considered. Further studies in a large population are necessary to judge which ASDs are more at risk to reduce bone mineralization than others.
Preoperative Surgical Site Hair Removal for Elective Abdominal Surgery: Does It Have Impact on Surgical Site Infection
Authors: Dhamnaskar Suchin , Mandal Sumit , Koranne Mandar , Patil Pratik 
Published: August 2022

Abstract
Introduction Postoperative surgical site infection (SSI) forms the major burden of nosocomial infections in surgical patients. There is prevalent practice of surgical site hair shaving as a part of preoperative preparation. There is uncertainty regarding the benefit versus harm of shaving for SSIs. Hairs at surgical sites are removed prior to surgery most often by shaving. We performed this study to look for what impact preoperative hair removal by shaving has on postoperative SSI.
Methods We performed prospective comparative cohort study in patients undergoing elective abdominal surgeries. We included clean and clean-contaminated surgeries in immunocompetent patients of which half were shaved and other half not shaved prior to surgery. Other confounding factors like skin cleaning, aseptic technique of surgery, antibiotic prophylaxis and treatment, and postoperative wound care were as per care. Patients were assessed for presence and grade of SSI postoperatively on day 7, 14, and 30. Results were analyzed statistically using chi-square and Fischer's exact tests for significance in entire sample as well as in demographic subgroups.
Results Overall SSI rate was 11.42%. There was no statistically significant difference in SSI rates between patients who underwent preoperative surgical site hair removal by shaving (232) and who did not have shaving (232) on all the three different assessment timelines in postoperative period, namely, day 7, 14, and 30. Although the absolute number of patients who had SSI was more in those who underwent preoperative surgical site hair removal by shaving, the difference was not statistically significant (p > 0.05). But on subgroup analysis patients with clean-contaminated surgeries (p = 0.037) and patients with surgeries lasting for less than 2 hours (Fischer's exact = 0.034) had significantly higher SSI in the shaved group compared with unshaved on day 14.
Conclusion As per our results, preoperative shaving did not significantly increase overall SSI except in subgroup of clean-contaminated surgeries and in surgeries of less than 2 hours' duration. So especially in these patients avoiding preoperative surgical site hair shaving may be used as one of the infection control measures.
Central Nervous System Involvement in Dengue Virus Type 1 Infection: A Pediatric Case Series
Authors: Pattrakornkul Nalinee , Siriboriruk Jukrapun 
Published: August 2022

AbstractCentral nervous system involvement accounted for 0.5 to 21.2% of dengue virus infections. Dengue virus type 2 and type 3 were commonly found in patients with central nervous system manifestations, while dengue virus type 1 (DENV-1) was rarely reported. We reported three dengue fever cases with neurological complications associated with DENV-1 infection. A previously healthy boy presented with fever, agitation, and an altered mental status in the first case. The other two cases presented with fever and seizures. All of them had no plasma leakage from dengue infection. DENV-1 was detected by reverse transcriptase-polymerase chain reaction assay in cerebrospinal fluid, serum, or both. All three cases were resolved entirely without neurological sequelae. This study can alert hospitals to prepare for the next epidemic in which there could be increasing cases of unusual or severe manifestations of dengue.
Doxycycline: An Antibiotic Attenuates Oxidant Stress, Perturbation of Lipid Metabolites, and Antioxidants against Vanadium Toxicity in Rat Hepatocytes
Authors: Gassar Ezeddin Salem , Mohamed Negia Abdullah Emtawel , Emtawel Fatema Abdullah , Elfakhri Rehab M. , Haider Syed Saleem 
Published: August 2022

Background The liver is target following exposure to pentavalent vanadium (V5+). Doxycycline is an antioxidant that prevents the progression of disease through inhibition of lipid peroxidation.
Aim The present study was designed to evaluate the protective effects of doxycycline against vanadium-induced hepatoxicity.
Methods Sixty two male Sprague-Dawley rats (250–300 g) were equally divided into the following four groups: control group (received 0.2 mL of physiological saline), doxycycline control group (received 4 mg/kg body weight on day 1 and 2 mg/kg body weight daily thereafter), vanadium group (received elemental vanadium 1.5 mg/kg-body weight in distilled water), and concomitantly treated group (doxycycline + vanadium) received (doxycycline 4 mg/kg body weight on day 1 and 2 mg/kg body weight thereafter + vanadium 1.5 mg/kg body weight), all given orally for 10 consecutive days. The rats were sacrificed by decapitation 24 hours after the last dose. The liver was removed rapidly and processed for the evaluation of metabolic variables: phospholipids, cholesterol, cerebrosides, gangliosides, reduced glutathione (GSH), vitamin C, calcium, acetylcholinesterase enzyme, and lipid peroxidation.
Results Vanadium administration significantly reduced (−60 g) the body weight and significantly increased (+28%) the relative liver weight compared with controls. The rats exhibited neurological function deficits. Vanadium administration decreased the concentrations of metabolic variables compared with controls, cerebrosides (−50%), cholesterol (−39%), phospholipids (−18%), GSH (−45%), and inhibited acetylcholinesterase enzyme (–48%). Gangliosides (+ 38%), vitamin C (+ 20%), and calcium (+ 80%) were increased together with an enhancement (+64%) in lipid peroxidation. The combined treatment (vanadium and doxycycline) significantly increased (+25 g) the body weight and relative liver weight of rat was significantly reduced (+5%) compared with vanadium administered group. The levels of metabolic variables were significantly reversed in this group in the following order: cholesterol (+17%), phospholipids (+7%), vitamin C (−14%), acetylcholinesterase enzyme activity (−27%) together with inhibition (−16%) of lipid peroxidation. All levels were (p < 0.05). Doxycycline presented no effect on the levels of GSH, cerebrosides, and gangliosides.
Conclusion Results of this study suggested vanadium-induced oxidation of lipids and sphingolipids in hepatocytes and much of GSH was consumed against high production of reactive oxygen species. Doxycycline protected against vanadium-induced oxidative damage that could be attributed to its free radical scavenging effects on membrane-bound lipids and acetylcholinesterase enzyme.
Cerebrovascular Complications in Pediatric Patients with COVID-19 Infection
Authors: Chaudhry Thymur Ali , Palabiyik Figen , Moum Sarah J. 
Published: August 2022

AbstractSince the onset of the coronavirus disease 2019 pandemic, a variety of neurological manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported in patients, of which one of the most concerning is stroke. This review aims to summarize the current literature and evolving understanding of pediatric cerebrovascular complications in the setting of SARS-CoV-2.
Patient-Specific Factors Associated with Dexmedetomidine Dose Requirements in Critically Ill Children
Authors: Crisamore Karryn R. , Empey Philip E. , Pelletier Jonathan H. , Clark Robert S. B. , Horvat Christopher M. 
Published: August 2022

AbstractThe objective of this study was to evaluate patient-specific factors associated with dexmedetomidine dose requirements during continuous infusion. A retrospective cross-sectional analysis of electronic health record-derived data spanning 10 years for patients admitted with a primary respiratory diagnosis at a quaternary children's hospital and who received a dexmedetomidine continuous infusion (n = 346 patients) was conducted. Penalized regression was used to select demographic, clinical, and medication characteristics associated with a median daily dexmedetomidine dose. Identified characteristics were included in multivariable linear regression models and sensitivity analyses. Critically ill children had a median hourly dexmedetomidine dose of 0.5 mcg/kg/h (range: 0.1–1.8), median daily dose of 6.7 mcg/kg/d (range: 0.9–38.4), and median infusion duration of 1.6 days (range: 0.25–5.0). Of 26 variables tested, 15 were selected in the final model with days of dexmedetomidine infusion (β: 1.9; 95% confidence interval [CI]: 1.6, 2.3), median daily morphine milligram equivalents dosing (mg/kg/d) (β: 0.3; 95% CI: 0.1, 0.5), median daily ketamine dosing (mg/kg/d) (β: 0.2; 95% CI: 0.1, 0.3), male sex (β: −1.1; 95% CI: −2.0, −0.2), and non-Black reported race (β: −1.2; 95% CI: −2.3, −0.08) significantly associated with median daily dexmedetomidine dose. Approximately 56% of dose variability was explained by the model. Readily obtainable information such as demographics, concomitant medications, and duration of infusion accounts for over half the variability in dexmedetomidine dosing. Identified factors, as well as additional environmental and genetic factors, warrant investigation in future studies to inform precision dosing strategies.
Foreign direct investment and the innovation performance of local enterprises
Authors: Yue Wen 
Published: August 2022

AbstractBased on the micro data set of Chinese manufacturing enterprises, this study examines in detail the impact of foreign direct investment on the innovation performance of Chinese local enterprises and its mechanism. Results show that foreign direct investment helps to improve the innovation performance of Chinese local enterprises, and spillover effect and competition effect are important ways for foreign direct investment to affect the innovation performance of local enterprises. In addition, the impact of foreign direct investment on the innovation of local enterprises of different types varies. Foreign direct investment has significantly promoted the innovation of high-productivity, capital-intensive, non-coastal, export, and non-state-owned enterprises. This study enriches the research literature on foreign direct investment and enterprise innovation and provides new micro evidence for understanding the impact of foreign direct investment on the innovation performance of local enterprises.
Impact of energy poverty on cognitive and mental health among middle-aged and older adults in China
Authors: Li Xuefeng , Yang Han , Jia Jin 
Published: August 2022

AbstractEnergy poverty (EPOV) is considered to have a significant impact on health and has become an essential issue on the policy agenda in most countries, especially those with rapid aging. Cognitive and mental health (CMH) for aging well is just as important a component as physical health, but the literature on the effect of EPOV on CMH is still rare. Using 2014–2018 China Family Panel Studies (CFPS), this study explores EPOV and its impacts on CMH among middle-aged and older adults. Six measures based on energy affordability are constructed to capture the state of EPOV. The results show that the proportion of middle-aged and older adults living in EPOV in China ranges from 24.3% to 27.8%, according to different measures. Applying a two-way FE model, the estimates show that overall, the impact of EPOV on CMH is significantly negative. Furthermore, physical health is an important channel through which EPOV affects CMH. Although EPOV has a significant adverse effect on the CMH of both middle-aged and older adults, it harms the latter more.
A modified Michelson interferometer to measure sub-milliradian changes in angle
Authors: LeDesma C. K. , Ross M. P. , Daly B. E. , Hoyle C. D. , Mola M. M. 
Published: August 2022

Modern short-range gravity experiments that seek to test the Newtonian inverse-square law or weak equivalence principle of general relativity typically involve measuring the minute variations in the twist angle of a torsion pendulum. Motivated by various theoretical arguments, recent efforts largely focus on measurements with test mass separations in the sub-millimeter regime. To measure the twist, many experiments employ an optical autocollimator with a noise performance of ∼300 nrad/Hz in the 0.1–10 mHz band, enabling a measurement uncertainty of a few nanoradians in a typical integration time. We investigated an alternative method for measuring a small twist angle through the construction of a modified Michelson interferometer. The main modification is the introduction of two additional arms that allow for improved angular alignment. A series of detectors and LabView software routines were developed to determine the orientation of a mirror attached to a sinusoidally driven rotation stage that oscillated with an amplitude of 0.35 mrad and a period of 200 s. In these measurements, the resolution of the interferometer is 8.1 μrad per fringe, while its dynamic range spanned 0.962 mrad. We compare the performance of this interferometric optical system to existing autocollimator-based methods, discussing its implementation, possible advantages, and future potential, as well as disadvantages and limitations.
De novo mutations in KIF1A-associated neuronal disorder (KAND) dominant-negatively inhibit motor activity and axonal transport of synaptic vesicle precursors
Authors: Anazawa Yuzu , Kita Tomoki , Iguchi Rei , Hayashi Kumiko , Niwa Shinsuke 
Published: August 2022

KIF1A is a kinesin superfamily motor protein that transports synaptic vesicle precursors in axons. Cargo binding stimulates the dimerization of KIF1A molecules to induce processive movement along microtubules. Mutations in human
Kif1a
lead to a group of neurodegenerative diseases called KIF1A-associated neuronal disorder (KAND). KAND mutations are mostly de novo and autosomal dominant; however, it is unknown if the function of wild-type KIF1A motors is inhibited by heterodimerization with mutated KIF1A. Here, we have established
Caenorhabditis elegans
models for KAND using CRISPR-Cas9 technology and analyzed the effects of human KIF1A mutation on axonal transport. In our
C. elegans
models, both heterozygotes and homozygotes exhibited reduced axonal transport. Suppressor screening using the disease model identified a mutation that recovers the motor activity of mutated human KIF1A. In addition, we developed in vitro assays to analyze the motility of heterodimeric motors composed of wild-type and mutant KIF1A. We find that mutant KIF1A significantly impaired the motility of heterodimeric motors. Our data provide insight into the molecular mechanism underlying the dominant nature of de novo KAND mutations.
Indirect translation of foreign films for cinematic release in China
Authors: Jin Haina , Zhang Yichi , He Xiaomin 
Published: August 2022

Abstract
Scholars have acknowledged the widespread use of indirect translation in audiovisual translation. Some researchers have made use of text analysis to explore the effects of indirect translation on voiceover and subtitling. However, a bigger picture of indirect translation in the audiovisual translation landscape is yet to be painted. We create a database of 242 foreign films, which contains all the imported films for cinematic release in China in 2018 and 2019, and do a quantitative and qualitative analysis to present an overview of indirect translation of foreign films for cinematic release in China. Professionals from film translation studios in China are interviewed to reveal the indirect translation process. Furthermore, we use Prooi ‘Prey’ (Maas 2016), a Dutch horror film directed by Dick Maas, and its Chinese subtitled version as a case study to investigate the implications of indirect translation on the ultimate target text in the Chinese context.
Listening effort in individuals with noise-induced hearing loss
Authors: Shetty Hemanth Narayan , Raju Suma , Kumar Yashwanth , Singh Sanjana S. 
Published: August 2022

Objective
The cognitive capacity allocates the resources effectively for effortless listening to speech presented in noise. This entity is minimally explored in individuals with noise-induced hearing loss (NIHL); therefore, the listening effort in individuals with NIHL at different signal-to-noise ratios was investigated.

Method
Forty participants with symmetrical mild sensorineural hearing loss were sub-grouped into control and clinical groups. The listening effort was measured using the dual-task paradigm at four different signal-to-noise conditions. In addition, a gap detection test was used to assess temporal processing ability.

Results
The repeat and recall scores were reduced with decreased signal-to-noise ratios in each group. These differences were significantly poorer in the clinical group than in the control group. A significant strong positive relation was observed between the recall and repeat scores of both groups for the listening effort tasks. Temporal processing impairment was significantly higher in the clinical group than in the control group.

Conclusion
Individuals with noise-induced hearing loss exhibit a significant temporal processing impairment that leads to effortful listening than hearing loss alone.
Deep band modulation, frequency discrimination, temporal resolution and audibility effects
Authors: Shetty Hemanth Narayan , Raju Suma 
Published: August 2022

Objective
The temporal envelope enhancement using deep band modulation (DBM) exaggerates the temporal peaks and valleys in the speech signal, thereby reducing the difficulty in the perception of speech in noise.

Method
Ten participants in each group of older adults with and without hearing loss in 65 to 83 years were recruited. A repeated measures research design was utilised to investigate phrase perception in unprocessed and deep band modulated phrases at different signal-to-noise (SNR) ratios (−4, 0, and +4). Temporal processing, spectral discrimination and speech intelligibility index were assessed.

Results
Regardless of the group, the phrase perception in the deep band modulated condition was significantly better than the unprocessed condition at each SNR. A significantly strong negative correlation was observed between: Gap detection threshold (GDT) and phrase perception scores in unprocessed condition at −4 dB SNR in each group; frequency difference limen in each condition and DBM phrase perception at −4 dB SNR in the older adult group with hearing impaired (OAG-HI) group. Furthermore, audibility reflected in the speech intelligibility index (SII) did not influence phrase recognition irrespective of condition, SNRs and group.

Conclusion
Increased modulation depth enables the participants to use the available temporal envelope, especially at the portion of the phrase where noise is less energetically masked.