bluuebunny/crossref_metadata_2025_split huggingface dataset:
PSPC1 is a potential prognostic marker for hormone-dependent breast cancer patients and modulates RNA processing of ESR1 and SCFD2
Authors: Takeiwa Toshihiko , Ikeda Kazuhiro , Suzuki Takashi , Sato Wataru , Iino Kaori , Mitobe Yuichi , Kawabata Hidetaka , Horie Kuniko , Inoue Satoshi 
Published: June 2022

AbstractBreast cancer is the most common cancer type among women worldwide. The majority of breast cancer expresses estrogen receptor (ER) and endocrine therapy is a standard treatment of ER-positive breast cancer. However, development of the therapy resistance is still a major challenge and thus new therapeutic approaches are needed. Here we show that an RNA-binding protein, PSPC1, play a crucial role in ER-positive breast cancer growth through post-transcriptional gene regulation. We showed that siRNA-mediated PSPC1 silencing suppressed the proliferation of ER-positive breast cancer cells. Strong immunoreactivity (IR) of PSPC1 was correlated with poor prognosis for ER-positive breast cancer patients. Using immunoprecipitation, RNA-immunoprecipitation (RIP) and quantitative PCR (qPCR) experiments, we showed that PSPC1 interacted with PSF and was involved in post-transcriptional regulation of PSF target genes, ESR1 and SCFD2. Strong SCFD2 IR was correlated with poor prognosis for ER-positive breast cancer patients and combinations of PSPC1, PSF, and SCFD2 IRs were potent prognostic factors. Moreover, we identified DDIAS and MYBL1 as SCFD2 downstream target genes using microarray analysis, and finally showed that SCFD2 silencing suppressed tamoxifen-resistant breast tumor growth in vivo. These results indicated that PSPC1 and SCFD2 axis could be a promising target in the clinical management of the disease.
A measure to estimate the risk of imported COVID-19 cases and its application for evaluating travel-related control measures
Authors: Kang Heewon , Min Kyung-Duk , Jeon Seonghee , Lee Ju-Yeun , Cho Sung-il 
Published: June 2022

AbstractHigh connectivity between nations facilitates the spread of infectious diseases. We introduce an improved measure to estimate the risk of COVID-19 importation. The measure was applied to identify the effectiveness of travel-related control measures. We estimated the risk of importation, using the product of air-travel volume and COVID-19 prevalence in the area-of-origin. Travel volumes were acquired through real-time mobile data, and prevalence was calculated considering the time-varying strength of the COVID-19 testing policy. With the measure, the number of expected-imported cases was calculated, and compared with the reported-imported COVID-19 cases before and after post-entry quarantine for all entrants. The expected and reported-imported cases were well fitted (R2 = 0.8). A maximum of 35 undetected-imported cases was estimated to have entered Seoul, before the first imported COVID-19 case was confirmed. With the travel-related control measures, at most, 48 (73%) imported cases could be isolated from the local community. Our measure predicted trends in imported COVID-19 cases well. The method used to develop the measure can be applied to future emerging infectious diseases. Our results provide a ‘real-world’ evidence that travel-related control measures are effective at curbing further COVID-19 transmission.
A predictive risk score to diagnose hypocalcemia after parathyroidectomy in patients with secondary hyperparathyroidism: a 22-year retrospective cohort study
Authors: Phimphilai Mattabhorn , Inya Suchada , Manosroi Worapaka 
Published: June 2022

AbstractHypocalcemia is a common complication found in patients with secondary hyperparathyroidism (SHPT) who undergo parathyroidectomy. This study aimed to construct a predictive risk score for the occurrence of hypocalcemia after parathyroidectomy in patients with SHPT who underwent chronic renal replacement therapy (RRT). This 22-year retrospective cohort study enrolled 179 patients with SHPT who had their first parathyroidectomy. Eighty-two percent of patients developed hypocalcemia within 16.9 (95% CI 14.5–19.5) h after parathyroidectomy. This study demonstrated four factors as independent risk factors for post-parathyroidectomy hypocalcemia, including duration of RRT, preoperative serum phosphate, preoperative serum alkaline phosphatase (ALP) and mean difference of serum intact parathyroid hormone (iPTH). By using logistic regression analysis, this study demonstrated cut-off points for these four risk factors for the diagnosis of hypocalcemia after parathyroidectomy: 5 years for the duration of RRT, 5 mg/dL for serum phosphate, 387 U/L for serum ALP, and 97% for the mean difference of serum iPTH. Finally, the predictive risk score was constructed by assigning a score of one to each factor. With a total score of at least 2, the proposed predictive risk score has an AuROC of 0.755 with a sensitivity of 78.2%, a specificity of 71.4%, and an accuracy of 76.9%.
Histomorphological and ultrastructural cadmium-induced kidney injuries and precancerous lesions in rats and screening for biomarkers
Authors: Wan Xichen , Xing Zelong , Ouyang Jin , Liu Hui , Cheng Chengquan , Luo Ting , Yu Shiqun , Meihua Li , Huang Shaoxin 
Published: June 2022

Abstract
Long-term exposure to cadmium (Cd) can severely damage the kidney, where orally absorbed Cd accumulates. However, the molecular mechanisms of Cd-induced kidney damage, especially the early biomarkers of Cd-induced renal carcinogenesis, are unclear. In the present study, we established a rat kidney injury model by intragastric administration of Cd to evaluate the morphological and biochemical aspects of kidney injury. We randomly divided Sprague-Dawley rats into control, low Cd (3 mg/kg), and high Cd (6 mg/kg) groups and measured biochemical indices associated with renal toxicity after 2, 4, and 8 weeks of treatment. The Cd-exposed mice had significantly higher Cd concentrations in blood and renal tissues as well as blood urea nitrogen (BUN), β2-microglobulin (β2-MG), urinary protein excretion, and tumor necrosis factor-α (TNF-α) levels. Furthermore, histopathological and transmission electron microscopy (TEM) observations revealed structural disruption of renal tubules and glomeruli after 8 weeks of exposure to the high Cd regimen. Besides, microarray technology experiments showed that Cd increased the expression of genes related to the chemical carcinogenesis pathway in kidney tissue. Finally, combining the protein–protein interaction (PPI) network of the Cd carcinogenesis pathway genes with the microarray and Comparative Toxicogenomics Database (CTD) results revealed two overlapping genes, CYP1B1 and UGT2B. Therefore, the combined molecular and bioinformatics experiments’ results suggest that CYP1B1 and UGT2B are biomarkers of Cd-induced kidney injury with precancerous lesions.
Clinicians' Perspectives of Treatment for Lateralization Errors: A Quantitative and Qualitative Study
Authors: Overby Megan S. , Mazeika Sarah , DiFazio Magdalena , Ioli Julianna , Birch Katherine , Devorace Lauren 
Published: June 2022

Purpose:
This mixed-methods study aimed to obtain information regarding speech-language pathologists' (SLPs) perspectives about treatment of lateralization errors (LEs), challenges to implementing evidence-based LE treatment practice, and the sources SLPs' use to find evidence to treat LEs. This information can assist our understanding of ways to facilitate the uptake of evidence-based practice into the everyday treatment of clients with this disorder.

Method:

A convergent parallel mixed-methods design was used to collect data from SLPs (
N
= 214) using 24 questions from an online survey distributed through electronic mailing lists and Speech and Hearing State Associations. Quantitative data were analyzed using frequencies and averages; themes and subthemes of qualitative data were analyzed using a content analysis approach with no a priori codes. Quantitative and qualitative results were compared and integrated.

Results:
Participants believed that LEs required individualized treatment before the age of 5 years, were largely caused by structural and neuromuscular factors, and required an understanding of orofacial and dental structure and function. Challenges to implementing LE treatment included a lack of skills and knowledge specific to LEs, competing demands on clinicians' time and resources, and a research–practice gap. Sources of evidence frequently used to obtain information about LE treatment were colleagues, trainings, workshops, and American Speech-Language-Hearing Association journals.

Conclusions:
Clinicians believe that LE treatment is challenging and requires skill training. Future research in LEs will need to consider the real-world decisions clinicians must make when treating this disorder as well as clinicians' everyday constraints and challenges.
Systematic evaluation of recursive approach of EEG‐segment‐based PCA for removal of helium‐pump artefact from MRI
Authors: Kim Hyun‐Chul , Lee Jong‐Hwan 
Published: June 2022

AbstractThe cryogenic pump is a crucial component of the magnetic resonance imaging (MRI) system for delivering liquid helium to a magnet for superconductivity, thereby generating a mechanical vibration. Thus, the cryogenic pump for liquid helium (helium pump) contaminates the electroencephalography (EEG) simultaneously acquired with functional MRI. The recursive approach of EEG‐segment‐based principal component analysis (rsPCA) has recently demonstrated its efficacy in removing this helium pump artefact. In the rsPCA, the recursion depth and EEG‐segment size are crucial hyperparameters. rsPCA's performance and computational time across recursion depth (1, 2, 3) and segment sizes (165, 220, 265) are systematically evaluated. It is found that the recursion depth of 2 yielded significant reductions in the computational time compared to the depth of 3 across all segment sizes while maintaining the denoising performance. The binary classification performance (left‐hand versus right‐hand clenching) was also enhanced in this scenario (especially the use of EEG‐segment size of 165 and 220) by using EEG gamma‐band activity (30–50 Hz), which is predominantly contaminated by the helium‐pump artefact.
Video storytelling based on gated video memorability filtering
Authors: Lu Youwei , Wu Xiaoyu 
Published: June 2022

AbstractVideo storytelling aims to generate a successive and succinct paragraph composed of multiple sentences to describe the visual contents in a long video. The major difficulty with video storytelling is the conflict between complex visual semantics and concise textual description. Existing methods address this problem by applying different segmentation strategies to long videos. However, these methods ignore that some story‐irrelevant visual contents could be considered as noises, so visual information in a long video is not always conducive to story generation. Therefore, we propose a novel video storytelling model based on gated video memorability filtering (GVMF), which generates high‐quality textual descriptions by filtering out clips with lower memorability scores, where objects and characters appear less frequently. The reason for introducing video memorability prediction is that video clips with higher video memorability scores tend to have more characters and objects so tend to be noticed by annotators for writing sentences. Experimental results demonstrate the effectiveness and competitiveness of our method, which achieves the new state‐of‐the‐art results on Video Story dataset.
Semi‐supervised breast histopathological image classification with self‐training based on non‐linear distance metric
Authors: Liu Kun , Liu Zhuolin , Liu Sidong 
Published: June 2022

AbstractHistopathological analysis requires a lot of clinical experience and time for pathologists. Artificial intelligence (AI) may have an important role in assisting pathologists and leading to more efficient and effective histopathological diagnoses. To address the challenge of requiring a large number of labelled images to train deep learning models in breast cancer histopathological image classification, a self‐training semi‐supervised learning method consisting three components is proposed: Firstly, a pre‐trained ResNet‐18 was used to extract features and generate pseudo‐labels for unlabelled data; secondly, a relational weight network based on the squeeze‐and‐excitation network (SENet) was trained to calculate the non‐linear distance metrices between labelled and unlabelled samples, in order to improve the accuracy of pseudo‐labelling; lastly, a consistency loss—maximum mean difference (MMD)—was added into the model to minimize the divergence between distributions of unlabelled and labelled samples. Extensive experiments were conducted on the open access BreakHis dataset. The proposed method outperformed the state‐of‐the‐art semi‐supervised methods at all tested annotated percentages (10–70%), and also achieved comparable performance with supervised methods at higher annotated percentages (50%, 70%).
ESC-Leitlinie Herzschrittmacher 2021 - Leadless
Pacing
Authors: Sultan Arian 
Published: June 2022

ZusammenfassungIm vergangenen Jahr wurde auf dem ESC Kongress die neue Leitlinie zur
Schrittmachertherapie vorgestellt. Ein besonderes Augenmerk lag hier auf der
Indikationsempfehlung zur kabellosen Schrittmachertherapie. Aktuell sind 2
kabellose Schrittmachersysteme kommerziell erhältlich. Zum einen der asynchron
arbeitende Micra VR sowie der AV-synchron operierende Micra AV. Beide Systeme
werden kathetergestützt, in der Regel über einen rechts-femoralen Venenzugang im
rechten Ventrikel platziert. Der Micra VR wird überwiegend bei Patienten mit
intermittierender Bradykardie bei persistierendem oder permanentem
Vorhofflimmern verwendet. Mit der Einführung des Micra AV konnte das
Indikationsspektrum deutlich erweitert werden. Dieser Schrittmacher erlaubt nun
auch eine kabellose Schrittmacherimplantation bei Patienten mit erhaltener
Sinusknotenfunktion und höhergradigen AV-Blockierungen. Die aktuellen Leitlinien
haben für die Implantation eines kabellosen Schrittmachers eine
Klasse-IIa-Empfehlung, Level B lediglich für bestimmte Patientengruppen
ausgesprochen.
Herzschrittmachertherapie bei Sinusknotenerkrankung, Reflexsynkopen, seltenen Herzerkrankungen & besonderen Situationen
Authors: Wiegand Uwe 
Published: June 2022

ZusammenfassungDurch die neuen ESC-Leitlinien zur Herzschrittmacher- und kardialen Resynchronisationstherapie ändert sich die Indikationsstellung nur in wenigen Bereichen. Für Patienten mit
Tachykardie-Bradykardie-Syndrom, bei denen Vorhofflimmern nicht primär mit Katheterablation behandelt werden soll, wird die Indikation zur Schrittmachertherapie erleichtert. Gleiches gilt
aber auch für Patienten mit Sinusknotenerkrankung und vermutetem Symptom-EKG-Zusammenhang, die nun im Gegensatz zu den Leitlinien von 2013 auch bei leichter Symptomatik und ohne definierte
Pausenlänge im Einzelfall einen Schrittmacher erhalten können. Bei Verdacht auf Reflexsynkopen wird analog zur Synkopenleitlinie von 2018 ein diagnostischer Algorithmus aus
Kipptischuntersuchung, Karotis-Druckversuch und – im Fall von nicht diagnostischen Ergebnissen – Implantation eines Ereignisrekorders empfohlen. Erstmals finden sich auch eigenständige
Indikationen zur Schrittmachertherapie nach Implantation von Transkatheter-Aortenklappen.
CRT „reloaded“ 2022 – die neuen Guidelines und technische Innovationen
Authors: Butter Christian , Seifert Martin , Georgi Christian 
Published: June 2022

ZusammenfassungDie kardiale Resynchronisationstherapie (cardiac resynchronization therapy, CRT) stellt für Patienten mit symptomatischer Herzinsuffizienz und Linksschenkelblock eine etablierte und
erfolgreiche Therapieoption dar, wenn die konservative medikamentöse Therapie ausgeschöpft ist und alle anderen kausalen Ursachen wie Ischämie, Klappenfehler und Rhythmusstörungen behandelt
worden sind. Die aktuellen Pacing-Guidelines der ESC betonen erneut den Stellenwert der CRT als primäre interventionelle Herzinsuffizienztherapie, besonders bei Sinusrhythmus, einer LVEF
≤ 35% und typischem Linksschenkelblock ≥ 150 ms. Bei gleichzeitig bestehendem unkontrollierbarem Vorhofflimmern gewinnt die AV-Knoten-Ablation an Bedeutung. Für den nicht zu
vernachlässigenden Anteil von Herzinsuffizienzpatienten ohne klare CRT-Indikation oder mit unzureichender CRT-Response kann eine multimodale Bildgebung zusätzliche Informationen liefern.
Alternative Pacingmethoden sollten bei anatomischen Hindernissen erwogen werden. Die Wahl eines zusätzlichen Defibrillators ist auch nach der aktuellen Studienlage häufig schwierig und
bleibt individuell abzuwägen.
Anastomose incomum entre ramos do nervo ulnar (variante anastomótica de Kaplan) – Relato de caso
Authors: Oliveira Kennedy Martinez , Benevenuto Gabriel das Chagas , de Almeida Ana Clara Ferreira , de Oliveira Daniel Gonçalves , Bueno Leonardo Braga , Teixeira Maria Fernanda Carvalho 
Published: June 2022

ResumoA anastomose de Kaplan é uma rara comunicação originalmente descrita entre os ramos superficial e dorsal do nervo ulnar, distal ao túnel ulnar e em estreita relação com o osso pisiforme. O que revela, pela sua particular localização, uma formação de alta expressividade clínico-cirúrgica. Neste trabalho, uma comunicação do tipo Kaplan, porém, ainda não relatada, é descrita a partir de um membro superior esquerdo com uma inusual conformação em alça, ou um looping, entre ramos do nervo ulnar, no osso pisiforme.
When to Suspect DRUJ's Instability in Children? Case Report of a Rare Presentation of Distal Forearm Fractures
Authors: Saugy Claire-Anne , Bregou Aline Bourgeois 
Published: June 2022

AbstractPediatric displaced distal metaphyseal ulnar fractures and distal radial buckle fractures are common. However, to the best of our knowledge, their association has never been specifically reported. Thus, classification and management of this pattern remain challenging especially in young children. Distal radioulnar joint (DRUJ)'s assessment is difficult. A Galeazzi-equivalent injury should be suspected. We report the case of a 2-year-old boy who presented the above-mentioned association of forearm fractures and compare our management with actual recommendations. We would recommend a low-suspicion threshold for DRUJ's instability in young children presenting with displaced distal metaphyseal ulnar fracture associated with distal radial buckle fracture. That suspicion should raise the necessity of appropriate treatment and follow-up.
Utility of Serum Uric Acid to High-Density Lipoprotein Ratio in Prediction of Glycemic Control
Authors: Chinnusamy Manokaran , Vishwanathan Ram Arvind , Janakiraman Sathiyanarayanan , Elayidath Roshna 
Published: June 2022

Abstract
Introduction India has witnessed diabetes as a growing problem and is on the verge of a diabetes mellitus (DM) epidemic. Glycemic control is the way to prevent the morbidity associated with diabetes. This study aimed to find out the utility of uric acid to the high-density lipoprotein (HDL) ratio (UHR) as a marker of diabetic control.
Methodology A hospital-based cross-sectional study was conducted among type-2 diabetic individuals who attended outpatient clinics and individuals who admitted to the inpatient wards of our hospital were enlisted. HDL cholesterol, serum uric acid, glycated hemoglobin were performed. Hemoglobin A1c (HbA1c) lower than 7% was classified as a good-controlled type-2 (DM) group and those with HbA1c between 7 and 10% were classified as uncontrolled type-2 DM group and those with HbA1c greater than 10% were classified as poorly controlled type-2 DM group. HbA1c was correlated with HDL, serum uric acid, and UHR.
Results Our study demonstrates that uric acid is inversely related to HbA1c and uric acid decreases following elevated HbA1c, and this relationship was statistically significant, whereas there was a nonsignificant inverse relationship between HDL and HbA1c and UHR with HbA1c.
Conclusion Established diabetics will have a lowering of uric acid as the diabetic control worsens and UHR could not be used as a marker of diabetic control.
Avaliação da amplitude do movimento perna-pé: Qual método de aferição é mais fidedigno?
Authors: Costa Marco Túlio , Tejerina Javier Felipe Salinas , Silva Cesar Augusto Lima da , Rêgo Itallo Epaminondas de Queiroz , Bergamasco Jordanna Maria Pereira , Marchi Neto Noé De 
Published: June 2022

Resumo
Objetivo Avaliar os métodos de mensuração do movimento perna-pé em tornozelos e pés normais comparando os resultados das medidas clínicas com a mensuração radiográfica e determinar qual é a amplitude do movimento perna-pé considerada normal.
Métodos O movimento perna-pé foi mensurado em 44 pacientes (60 pés) empregando um goniômetro tradicional, goniômetro digital, inclinômetro, aplicativo para smartphone, além da mensuração radiográfica (considerada padrão ouro). A dorsiflexão máxima foi alcançada pedindo ao paciente dar um passo à frente com o pé contralateral e realizar o máximo de dorsiflexão possível no tornozelo estudado sem retirar o calcanhar do solo. Já para a flexão plantar máxima, foi solicitado ao paciente para dar um passo para trás com pé contralateral e fazer o máximo de flexão plantar possível sem retirar o antepé estudado do solo.
Resultados Os valores obtidos na mensuração radiográfica foram maiores do que os obtidos com a mensuração clínica. Quando comparamos apenas os resultados da mensuração clínica, o goniômetro tradicional se mostrou impreciso. Segundo o método radiográfico, a média de amplitude do movimento perna-pé foi de 65,6 graus. Já a média da flexão plantar máxima foi de 34,9 graus, e a média da dorsiflexão máxima foi de 30,7 graus.
Conclusões O método mais adequado para a avaliação da amplitude do movimento perna-pé é o radiográfico. O goniômetro tradicional se mostrou o método clínico mais impreciso. A média de amplitude do movimento perna-pé em adultos jovens e saudáveis foi de 65 graus.
The Multifunctionality of MandarinDiào 掉
Authors: Jing Gaowa , Liu Meichun 
Published: June 2022

AbstractThis paper explores the various functions ofdiàoin Mandarin Chinese as it changes from a verb to a phase marker. As a phase marker,diàoprovides a natural endpoint to a co-occurring event and indicates completion, which is a distinct function from the perfect markerle. In this shift, the meaning ofdiàoalso expands, including ‘falling down’, ‘throwing down’, ‘disappearing’, ‘removal’, ‘completion’ and ‘change of state’. The multifunctionality ofdiàois the result of grammaticalization along with semantic change and extension. Cognitive mechanisms such as metonymic and metaphoric extensions, pragmatic inferencing, analogy on Verb-Complement structures, and semantic generalization all contribute to the grammaticalization ofdiào, with further influence from contact with southern Chinese dialects. This paper further argues that the grammaticalization and semantic extension ofdiàois in accordance with the development of aspectual markers cross-linguistically, reflecting the commonality in human cognition.
TV shows, authenticity, and language learning
Authors: Al-Surmi Mansoor 
Published: June 2022

AbstractOne of the many resources teachers seek for authentic materials, particularly for spoken English, is TV. However, the concept of authenticity is relative, and it is sometimes hard to determine how authentic materials are. The present study uses a corpus-based analysis to assess to what extent a soap opera, compared to a sitcom, represent natural conversation on a salient set of linguistic features associated with the situational characteristics of conversation. Results showed that the soap opera seems to be closer to natural conversation, and hence more authentic, in the use of features associated with two situational characteristics out of three, namelyreal time production and interactiveness, andexpressing feelings and stance. Results could help inform the practitioners’ decisions when looking for authentic spoken materials.