bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pohjoissuomenkarja lihantuottajana
Authors: Keto Liisa , Manni Katariina , Leskinen Heidi , Mazzullo Nuccio , Tuomivaara Anne , Soppela Päivi 
Published: June 2022

Pohjoissuomenkarja on Lapin maakunnan alkuperäinen nautarotu, joka on hyvin sopeutunut arktisiin olosuhteisiin, mutta jonka kestävyyttä ja monia hyviä ominaisuuksia hyödynnetään vielä hyvin vähän sen tarjoamiin mahdollisuuksiin nähden. Vuonna 2020 pohjoissuomenkarjan lehmiä (lisääntyviä naaraita) oli koko Suomessa noin 864 yksilöä ja rotu onkin luokiteltu uhanalaiseksi. Pohjoissuomenkarjan määrä kaksinkertaistuu Lapissa hankkeen toiminta-aikana, kun valtion omistama lapinlehmien geenipankkikarja siirtyy Tervolan Louelle Ammattiopisto Lappian hoitoon. Tämä yhdessä pohjoissuomenkarjatilallisten ja yrittäjien lisääntyneen kiinnostuksen kanssa luo hyvät lähtökohdat kehittää pohjoissuomenkarjaan perustuvaa liiketoimintaa, joka on tämän hankkeen tavoitteena. Lapin yliopiston Arktinen keskus vastaa Lapinlehmään perustuvan erikoistumisen mahdollisuudet osana pohjoisia elinkeinoja (Lappari-elinkeino) -hankkeen toteutuksesta yhteistyössä Luonnonvarakeskuksen ja Kemi-Tornionlaakson koulutuskuntayhtymä Lappian kanssa. Yksi hankkeen tavoitteista on tuottaa tietoa pohjoissuomenkarjan lihantuotanto-ominaisuuksista sekä lihan koostumuksesta, laadusta ja aistinvaraisista ominaisuuksista. Näistä tiedoista kootaan mm. maatila-, matkailu- ja lihayrittäjille sekä kuluttajille tietopaketteja. Samalla tavoitellaan pohjoissuomenkarjan tuotantoon liittyvien maatalous- ja elintarvikeyrittäjien verkostojen ja yhteistyön tiivistymistä. Naudanlihantuotanto Suomessa perustuu pääasiassa maidontuotantoon, jonka valtarotu Suomessa on holstein. Pohjoissuomenkarjan lihan erityislaadun selvittäminen voi tuoda sille uusia markkinoita erikoislihana, jolloin lihaa voitaisiin hyödyntää erikoistuotteena ja sille saataisiin lisäarvoa. Tässä hankkeessa toteutettavassa tutkimuksessa verrataan pohjoissuomenkarjan härkien lihan laatuominaisuuksia holstein-rotuisiin härkiin. Kokeessa on 12 pohjoissuomenkarja-rodun ja 12 holstein-rodun härkää, jotka kasvatetaan koko kokeen ajan yksityisellä maatilalla Tervolassa. Eläimet ruokitaan seosrehulla, joka koostuu nurmisäilörehusta ja rehuviljasta. Teurasikätavoite molempien rotujen eläimille on 19 kk. Eläimet teurastetaan useammassa teuraserässä normaalin teurastuskäytännön mukaisesti ja ruhojen painot punnitaan. Teurastuksen yhteydessä kustakin ruhosta otetaan ulkofilenäytteet, joista analysoidaan happamuus, väri, painotappio sekä lihan syöntilaatu ja kemiallinen koostumus. Koe alkoi keväällä 2021 ja se päättyy vuoden 2022 lopussa. Hankkeessa tuotetaan uutta tutkimustietoa ja käytännön osaamista pohjoissuomenkarjarotuisten eläinten kestävästä ja lisäarvoa tuottavasta hyödyntämisestä, ja pohjoissuomenkarjan lihan ominaisuuksista. Nämä lisäävät valmiuksia mm. pohjoissuomenkarjan lihan hyödyntämiseen ja pohjoissuomenkarjatuotteiden saamiseen markkinoille paikallisina erikoistuotteina.
PENGARUH CONTENT MARKETING INSTAGRAM TERHADAP BRAND IMAGE DISNEY+HOTSTAR DI MASA PANDEMI COVID-19
Authors: Pangestu Qayyum Deyatari , Tranggono Didiek 
Published: June 2022

Di masa pandemi COVID-19 ini, pemanfaatan media digital perlu dilakukan untuk memasarkan barang atau jasa pada suatu perusahaan. Hal ini dikarenakan mobilitas masyarakat yang dibatasi menjadikan pemasaran konvensional kurang efektif dalam menjangkau audiens. Dengan begitu pemasaran melalui media digital seperti content marketing menjadi salah satu kegiatan pemasaran yang tepat untuk dilakukan. Content marketing merupakan pemasaran yang memfokuskan pembuatan dan pendistribusian konten yang relevan dan berharga untuk menjangkau target audiens. Salah satu bisnis yang memanfaatkan content marketing adalah layanan hiburan streaming video on-demand Disney+ Hotstar melalui akun Instagram @disneyplushotstarid. Untuk dapat bersaing dengan layanan serupa, Disney+ Hotstar harus mempertimbangkan brand image yang dibangunnya melalui content marketing. Tujuan penelitian ini adalah untuk mengetahui adanya pengaruh dari content marketing di Instagram dalam membangun brand image Disney+ Hotstar selama pandemi COVID-19. Metode yang digunakan adalah metode kuantitatif deskriptif. Analisis menggunakan analisi regresi linier berganda dengan variabel X merupakan 5 dimensi dari content marketing, yaitu reader cognition (X1), sharing motivation (X2), persuasion (X3), decision making (X4), dan life factors (X5) dan variabel Y adalah brand image. Setelah melakukan analisis tersebut, hasil yang didapat adalah variabel-variabel content marketing memiliki pengaruh secara simultan maupun parsial terhadap variabel brand image. Namun, variabel persuasion memiliki pengaruh negatif terhadap variabel brand image (Y).
O correlato anímico da mimese poética nos escritos sobre a alma e a imaginação de Aristóteles
Authors: Nuesch Enrique 
Published: June 2022

Este texto trata de demonstrar que o conceito de mimese presente na Poética de
Aristóteles pode ser esclarecido pela relação com outros tratados do autor, nos quais se explora a imaginação enquanto potência da alma. Para isso, destacamos passagens importantes da poética, a partir das quais se tecem as relações com os demais textos. Conclui-se que uma investigação mais aprofundada sobre a imaginação pode trazer luz ao conceito de mimese da Poética, que não recebe definição naquele tratado.
Bioactive Bibenzyl Enantiomers From the Tubers of Bletilla striata
Authors: Zhou Mei , Jiang Sai , Chen Changfen , Li Jinyu , Lou Huayong , Wang Mengyun , Liu Gezhou , Liu Hanfei , Liu Ting , Pan Weidong 
Published: June 2022

Six new bibenzyls (three pairs of enantiomers), bletstrins D–F (1–3), were isolated from the ethyl acetate-soluble (EtOAc) extract of tubers of Bletilla striata (Thunb.) Rchb f. Their structures, including absolute configurations, were determined by 1D/2D NMR spectroscopy, optical rotation value, and experimental electronic circular dichroism (ECD) data analyses, respectively. Compounds 1–3 possess a hydroxyl-substituted chiral center on the aliphatic bibenzyl bridge, which represented the first examples of natural bibenzyl enantiomers from the genus of Bletilla. The antibacterial, antitumor necrosis factor (anti-TNF-α), and neuroprotective effects of the isolates have been evaluated. Compounds 3a and 3b were effective against three Gram-positive bacteria with minimum inhibitory concentrations (MICs) of 52–105 μg/ml. Compounds 2a and 2b exhibited significant inhibitory effects on TNF-α-mediated cytotoxicity in L929 cells with IC50 values of 25.7 ± 2.3 μM and 21.7 ± 1.7 μM, respectively. Subsequently, the possible anti-TNF-α mechanism of 2 was investigated by molecular docking simulation. Furthermore, the neuroprotective activities were tested on the H2O2-induced PC12 cell injury model, and compounds 2b, 3a, and 3b (10 μM) could obviously protect the cells with the cell viabilities of 57.86 ± 2.08%, 64.82 ± 2.84%, and 64.11 ± 2.52%, respectively.
Efficacy and Safety of Granulocyte-Colony Stimulating Factor Therapy in Chagas Cardiomyopathy: A Phase II Double-Blind, Randomized, Placebo-Controlled Clinical Trial
Authors: Macedo Carolina T. , Larocca Ticiana F. , Noya-Rabelo Márcia , Aras Roque , Macedo Cristiano R. B. , Moreira Moisés I. , Caldas Alessandra C. , Torreão Jorge A. , Monsão Victor M. A. , Souza Clarissa L. M. , Vasconcelos Juliana F. , Bezerra Milena R. , Petri Daniela P. , Souza Bruno S. F. , Pacheco Antônio G. F. , Daher André , Ribeiro-dos-Santos Ricardo , Soares Milena B. P. 
Published: June 2022

AimPrevious studies showed that granulocyte-colony stimulating factor (G-CSF) improved heart function in a mice model of Chronic Chagas Cardiomyopathy (CCC). Herein, we report the interim results of the safety and efficacy of G-CSF therapy vs. placebo in adults with Chagas cardiomyopathy.MethodsPatients with CCC, New York Heart Association (NYHA) functional class II to IV and left ventricular ejection fraction (LVEF) 50% or below were included. A randomization list using blocks of 2 and 4 and an allocation rate of 1:1 was generated by R software which was stratified by functional class. Double blinding was done to both arms and assessors were masked to allocations. All patients received standard heart failure treatment for 2 months before 1:1 randomization to either the G-CSF (10 mcg/kg/day subcutaneously) or placebo group (1 mL of 0.9% saline subcutaneously). The primary endpoint was either maintenance or improvement of NYHA class from baseline to 6–12 months after treatment, and intention-to-treat analysis was used.ResultsWe screened 535 patients with CCC in Salvador, Brazil, of whom 37 were randomized. Overall, baseline characteristics were well-balanced between groups. Most patients had NYHA class II heart failure (86.4%); low mean LVEF was 32 ± 7% in the G-CSF group and 33 ± 10% in the placebo group. Frequency of primary endpoint was 78% (95% CI 0.60–0.97) vs. 66% (95% CI 0.40–0.86), p = 0.47, at 6 months and 68% (95% CI 0.43–0.87) vs. 72% (95% CI 0.46–0.90), p = 0.80, at 12 months in placebo and G-CSF groups, respectively. G-CSF treatment was safe, without any related serious adverse events. There was no difference in mortality between both arms, with five deaths (18.5%) in treatment vs. four (12.5%) in the placebo arm. Exploratory analysis demonstrated that the maximum rate of oxygen consumption during exercise (VO2 max) showed an improving trend in the G-CSF group.ConclusionG-CSF therapy was safe and well-tolerated in 12 months of follow-up. Although prevention of symptom progression could not be demonstrated in the present study, our results support further investigation of G-CSF therapy in Chagas cardiomyopathy patients.Clinical Trial Registration[www.ClinicalTrials.gov], identifier [NCT02154269].
Indications, Complications, and Outcomes of Cardiac Surgery After Heart Transplantation: Results From the Cash Study
Authors: Gökler Johannes , Aliabadi-Zuckermann Arezu Z. , Kaider Alexandra , Ambardekar Amrut V. , Antretter Herwig , Artemiou Panagiotis , Bertolotti Alejandro M. , Boeken Udo , Brossa Vicens , Copeland Hannah , Generosa Crespo-Leiro Maria , Eixerés-Esteve Andrea , Epailly Eric , Farag Mina , Hulman Michal , Khush Kiran K. , Masetti Marco , Patel Jignesh , Ross Heather J. , Rudež Igor , Silvestry Scott , Suarez Sofia Martin , Vest Amanda , Zuckermann Andreas O. 
Published: June 2022

BackgroundAllograft pathologies, such as valvular, coronary artery, or aortic disease, may occur early and late after cardiac transplantation. Cardiac surgery after heart transplantation (CASH) may be an option to improve quality of life and allograft function and prolong survival. Experience with CASH, however, has been limited to single-center reports.MethodsWe performed a retrospective, multicenter study of heart transplant recipients with CASH between January 1984 and December 2020. In this study, 60 high-volume cardiac transplant centers were invited to participate.ResultsData were available from 19 centers in North America (n = 7), South America (n = 1), and Europe (n = 11), with a total of 110 patients. A median of 3 (IQR 2–8.5) operations was reported by each center; five centers included ≥ 10 patients. Indications for CASH were valvular disease (n = 62), coronary artery disease (CAD) (n = 16), constrictive pericarditis (n = 17), aortic pathology (n = 13), and myxoma (n = 2). The median age at CASH was 57.7 (47.8–63.1) years, with a median time from transplant to CASH of 4.4 (1–9.6) years. Reoperation within the first year after transplantation was performed in 24.5%. In-hospital mortality was 9.1% (n = 10). 1-year survival was 86.2% and median follow-up was 8.2 (3.8–14.6) years. The most frequent perioperative complications were acute kidney injury and bleeding revision in 18 and 9.1%, respectively.ConclusionCardiac surgery after heart transplantation has low in-hospital mortality and postoperative complications in carefully selected patients. The incidence and type of CASH vary between international centers. Risk factors for the worse outcome are higher European System for Cardiac Operative Risk Evaluation (EuroSCORE II) and postoperative renal failure.
Pre-transplant Type 2 Diabetes Mellitus Is Associated With Higher Graft Failure and Increased 5-Year Mortality After Heart Transplantation
Authors: Rivinius Rasmus , Gralla Carolin , Helmschrott Matthias , Darche Fabrice F. , Ehlermann Philipp , Bruckner Tom , Sommer Wiebke , Warnecke Gregor , Kopf Stefan , Szendroedi Julia , Frey Norbert , Kihm Lars P. 
Published: June 2022

AimsCardiac transplant recipients often suffer from type 2 diabetes mellitus (T2DM) but its influence on graft failure and post-transplant mortality remains unknown. The aim of this study was to investigate the long-term effects of pre-transplant T2DM in patients after heart transplantation (HTX).MethodsThis study included a total of 376 adult patients who received HTX at Heidelberg Heart Center between 01/01/2000 and 01/10/2016. HTX recipients were stratified by diagnosis of T2DM at the time of HTX. Patients with T2DM were further subdivided by hemoglobin A1c (HbA1c ≥ 7.0%). Analysis included donor and recipient data, immunosuppressive drugs, concomitant medications, post-transplant mortality, and causes of death. Five-year post-transplant mortality was further assessed by multivariate analysis (Cox regression) and Kaplan–Meier estimator.ResultsAbout one-third of all HTX recipients had T2DM (121 of 376 [32.2%]). Patients with T2DM showed an increased 5-year post-transplant mortality (41.3% versus 29.8%; P = 0.027) and had a higher percentage of death due to graft failure (14.9% versus 7.8%; P = 0.035). Multivariate analysis showed T2DM (HR: 1.563; 95% CI: 1.053–2.319; P = 0.027) as an independent risk factor for 5-year mortality after HTX. Kaplan–Meier analysis showed a significantly better 5-year post-transplant survival of patients with T2DM and a HbA1c &lt; 7.0% than patients with T2DM and a HbA1c ≥ 7.0% (68.7% versus 46.3%; P = 0.008) emphasizing the clinical relevance of a well-controlled T2DM in HTX recipients.ConclusionPre-transplant T2DM is associated with higher graft failure and increased 5-year mortality after HTX.
Arterial Stiffness, Biomarkers of Liver Fat, and the Development of Metabolic Dysfunction in Metabolically Healthy Population: A Prospective Study
Authors: Lin Lin , Wang Long , Du Rui , Hu Chunyan , Lu Jieli , Wang Tiange , Li Mian , Zhao Zhiyun , Xu Yu , Xu Min , Bi Yufang , Wang Weiqing , Ning Guang , Chen Yuhong 
Published: June 2022

BackgroundMetabolic dysfunction is known to be associated with arterial stiffness. However, the risks of metabolic syndrome and diabetes due to arterial stiffness and the potential mechanism remain unclear. We aimed to investigate the association of arterial stiffness with the risk of metabolic syndrome and diabetes, and determine whether this association is mediated by liver fat.MethodsA prospective study was conducted with 4,139 Chinese adults who were metabolically healthy at baseline. Arterial stiffness was measured by brachial–ankle pulse wave velocity (baPWV). Obesity was defined as body mass index ≥25 kg/m2. The primary outcomes were incident metabolic syndrome and diabetes.ResultsDuring a median follow-up of 4.4 years, 1,022 (24.7%) and 354 (9.5%) participants developed metabolic syndrome and diabetes, respectively. Compared with those in the lowest quartile of baPWV, participants in the highest quartile had 85 and 91% higher risks of metabolic syndrome and diabetes [risk ratio (RR) 1.85, 95% confidence interval (CI) 1.41, 2.42 for metabolic syndrome; RR 1.91, 95% CI 1.16, 3.15 for diabetes]. Mediation analyses indicated that fatty liver significantly mediated the association of arterial stiffness with metabolic syndrome and diabetes risk. Specifically, 18.4% of metabolic syndrome and 12.6% of diabetes risk due to arterial stiffness were mediated through fatty liver.ConclusionsArterial stiffness was associated with higher risks of metabolic syndrome and diabetes in individuals with obesity. This association may be partially mediated by fatty liver.
Development and Maintenance Mechanisms of a Long-Lived Mesoscale Vortex Which Governed the Earlier Stage of the “21.7” Henan Torrential Rainfall Event
Authors: Li Wanli , Ma Hui , Fu Rui , Han Hong , Wang Xiuming 
Published: June 2022

From 17 to 22 July 2021, a series of disastrous rainstorms appeared within Henan Province and its surroundings, which rendered 398 dead/missing and a direct economic loss of up to ∼114 billion Yuan. This event was named as the “21.7” Henan torrential rainfall event (TRE), and it could be divided roughly into three stages according to the precipitation features and dominant weather systems. This study mainly focused on the development and maintenance mechanisms of a long-lived (72 h) quasi-stationary mesoscale vortex that governed the earlier stage of the “21.7” TRE. Main results are as follows: 1) the mesoscale vortex formed/maintained in a favorable environment which was characterized by the South-Asia-high associated divergence in the upper troposphere, and the relay transport of relatively cold air by the trough and high-pressure system in the middle troposphere. 2) the vertical stretching due to lower-level convergence and the upward transport of cyclonic vorticity by ascending motions served as the first and second dominant factors for the mesoscale vortex’s rapid development and long-time maintenance, whereas, the import/export transport of anticyclonic/cyclonic vorticity into/from the vortex’s central region and the tilting effects were mainly detrimental for the vortex’s development/maintenance. 3) the air particles that formed the mesoscale vortex mainly came from the levels below 1,500 m, within the regions in lower latitudes. The air particles experienced notable precipitation before the formation of the mesoscale vortex, which contributed to the vortex’s formation through latent heat release.
Acromegaly Caused by Ectopic Growth Hormone Releasing Hormone Secretion: A Review
Authors: Zendran Iga , Gut Gabriela , Kałużny Marcin , Zawadzka Katarzyna , Bolanowski Marek 
Published: June 2022

IntroductionEctopic acromegaly is a rare condition caused most frequently by growth hormone releasing hormone (GHRH) secretion from neuroendocrine tumors. The diagnosis is often difficult to establish as its main symptoms do not differ from those of acromegaly of pituitary origin.ObjectivesTo determine most common clinical features and diagnostic challenges in ectopic acromegaly.Patients and MethodsA search for ectopic acromegaly cases available in literature was performed using PubMed, Cochrane, and MEDline database. In this article, 127 cases of ectopic acromegaly described after GHRH isolation in 1982 are comprehensively reviewed, along with a summary of current state of knowledge on its clinical features, diagnostic methods, and treatment modalities. The most important data were compiled and compared in the tables.ResultsNeuroendocrine tumors were confirmed in 119 out of 121 patients with histopathological evaluation, mostly of lung and pancreatic origin. Clinical manifestation comprise symptoms associated with pituitary hyperplasia, such as headache or visual field disturbances, as well as typical signs of acromegaly. Other endocrinopathies may also be present depending on the tumor type. Definitive diagnosis of ectopic acromegaly requires confirmation of GHRH secretion from a tumor using either histopathological methods or GHRH plasma concentration assessment. Hormonal evaluation was available for 84 patients (66%) and histopathological confirmation for 99 cases (78%). Complete tumor resection was the main treatment method for most patients as it is a treatment of choice due to its highest effectiveness. When not feasible, somatostatin receptor ligands (SRL) therapy is the preferred treatment option. Prognosis is relatively favorable for neuroendocrine GHRH-secreting tumors with high survival rate.ConclusionAlthough ectopic acromegaly remains a rare disease, one should be aware of it as a possible differential diagnosis in patients presenting with additional symptoms or those not responding to classic treatment of acromegaly.
Odor-Pollution From Fungicides Disrupts Learning and Recognition of a Common Floral Scent in Bumblebees (Bombus impatiens)
Authors: David Natalie F. , Henry Timothy J. , Sprayberry Jordanna D. H. 
Published: June 2022

Background and AimsBumblebees provide vital pollination services to both natural and agricultural ecosystems. Consequently their declines in species-diversity and population size over the last five decades is alarming. Direct contributors to these declines include pesticides, habitat loss, and disease. However, given that colony fitness is linked to foraging success, successful conservation requires mitigation of any anthropogenic practices that negatively impact foraging. Previous work has shown that agrochemical odor-pollution, including that of fungicides, can modulate bumblebee foraging behavior. This study investigates how odor pollution from three common fungicides (Safer® Brand Garden Fungicide II, Scotts® Lawn Fungus Control, and Reliant® Systemic Fungicide) affects Bombus impatiens’ floral-odor learning and recognition using an associative learning paradigm.MethodsThe effects of fungicide-odor pollution were tested in three ways: (1) background pollution during floral-odor learning; (2) background pollution during floral-odor recognition; and (3) point (localized) pollution during floral-odor recognition. Electroantennogram (EAG) recordings from B. impatiens confirmed the salience of all odor-stimuli and examined impacts of background fungicide-odor on antennal responses to floral-odor. To better understand how fungicide-odor structure related to behavioral data, scents were sampled (Solid Phase Microextraction) and analyzed using gas chromatography–mass spectrometry. Odors were then characterized using the Compounds Without Borders (CWB) vectorization method.ConclusionAll fungicides tested disrupted floral-odor learning and recognition for at least one concentration tested, and Scotts® was universally disruptive at all tested concentrations. All fungicides induced EAG responses, indicating they provide perceivable odor stimuli. Interestingly, two of three tested fungicides (Scotts® and Reliant®) inhibit antennal responses to Monarda fistulosa odor. Odor characterization supports previous findings that sulfurous scents could be disruptive to odor-driven foraging behaviors. Inability for foraging bumblebees to associate to rewarding floral odors in the presence of fungicidal odor pollution could have negative large-scale implications for colony health and reproductive fitness.