bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Different Doses of Amantadine on Lung Tissue In Hepatıc Ischemia Reperfusion Injury in Rats
Authors: ŞAHİN Fatih , ORHAN Mustafa , TAŞ TUNA Ayça , PALABIYIK Onur , ŞAHUTOĞLU BAL Nevcihan , GÖZÜKARA Sezen Irmak , BUDAK Özcan , ÇAKIROĞLU Hüseyin 
Published: October 2022

Objective: N-Methyl D-Aspartate (NMDA) receptor blockers have been shown to have protective effects against ischemia/reperfusion (I/R) injury in various tissues. The aim of this study was to investigate the effects of 90 ve 135 mg/kg doses of amantadine on lung in hepatic I/R injury.
Method: The rats were randomly divided into six groups: Group Sham, Group I/R, Group Amantadine-90, Group Amantadine-135, Group I/R-90 and Group I/R-135. In I/R, an atraumatic vascular clamp was applied to the structures in the left portal triad for 45 minutes and reperfusion period was 2 hours after ischemia. Malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) enzyme levels were performed the lung tissue and tissues were examined histopathologically.
Result: A significant difference was found between the groups in terms of MDA, SOD, CAT levels (respectively; p < 0.001, p=0.008, p < 0.001). A significant difference was found between the groups in terms of lung tissue neutrophil/lymphocyte infiltration scores and alveolar wall thickening scores (respectively p=0.009, p=0.002).
Conclusion: The biochemical and histopathological results of the present study suggested that amantadine, like other NMDA antagonist agents, may have a protective effect on lung tissues against the damage caused by hepatic I/R injury. Although we observed significant improvements after the administration of both doses studied, there was no significant difference between these two doses in terms of their success in protecting against distant organ lung injury. Amantadine appears promising as a therapeutic agent in treatment.
EKSTRAK DAUN KALIANDRA SEBAGAI INHIBITOR ALAMI LAJU KOROSI ST-37
Authors: Jufri Moh. , Surya Indra , Saifullah Ali , Suwarsono Suwarsono , Hendaryati Rr. Heni , Sudarman Sudarman 
Published: October 2022

Ekstrak daun kaliandra merupakan salah satu inhibitor alami yang dapat digunakan untuk menghambat laju korosi karena didalamnya terdapat kandungan senyawa tanin. Penelitian ini diawali dengan mengekstraksi daun kaliandra dengan cara maserasi kemudian dilanjutkan dengan evaporasi pada rotary vacuum evaporator untuk memisahkan pelarut dan ekstrak yang dihasilkan dan ekstrak tersebut digunakan sebagai inhibitor dengan konsentrasi 5%, 10%, dan 20 %. sampel uji korosi yang digunakan adalah baja ST-37 dengan ukuran 4 × 4 cm dan ketebalan 0,2 cm dalam media korosif air laut, HCl, dan H2SO4. Efisiensi inhibisi terbaik yang dihasilkan adalah 99,73%, dengan konsentrasi inhibitor 20% dalam larutan HCl. Yang berarti bahwa ekstrak daun kaliandra bekerja sangat baik dan efisien sebagai inhibitor laju korosi.
ANALYSIS OF STUNTING RISK FACTORS IN CHILDREN IN THE MAGETAN DISTRICT
Authors: Saadah Nurlailis , Yumni Hilmi , Mugianti Sri , Yulianto Budi 
Published: October 2022

Background: The condition of failure to thrive in toddlers due to chronic malnutrition and making children too short for their age is called stunting. Purpose: This research was conducted to analyze the risk factors of stunting in children. Methods: The study was conducted from mid-May to mid-August 2020. This study developed a model for maternal empowerment in preventing and managing stunting using a cross-sectional design, then implementing the model using a quasi-experimental non-randomized pre-post control group design. The population involved was all mothers with children under five years old in Posyandu Ngariboyo, Candirejo, and Plaosan, obtaining 250 mothers. Meanwhile, the study sample was 150 mothers who had children under five years old in Posyandu Ngariboyo, Candirejo, who met the inclusion criteria. Results: Mothers with good characteristics increased their knowledge of stunting prevention and control by 0.42 times (p=0.01). Mothers with good knowledge increased their maternal commitment by 0.23 (p=0.01), and mothers who had good commitment reduced stunting by 0.45 (p=0.01). Furthermore, mothers with good knowledge increased the family support by 0.24 (p=0.01). In addition, good family support also reduced stunting by 0.26 (p=0.01). Conclusion: Mother's knowledge contributes to the prevention and management of stunting. Children's physical health, family support, nutritional status, and home environment are also important factors in stunting prevention and management. Family support is needed by mothers to realize their commitment to carrying out early detection, prevention, and control stunting.
ANXIETY, DEPRESSION, MACRONUTRIENT INTAKE AND NUTRITIONAL STATUS OF CANCER SURVIVORS LIVING IN SHELTER HOUSES AFTER CHEMOTHERAPY: A CROSS-SECTIONAL STUDY
Authors: Indryani Nadya Ika , Purwanti Rachma , Margawati Ani , Nissa Choirun 
Published: October 2022

Depression and anxiety are common in cancer patients due to metabolism alteration and the side effects of chemotherapy. These mental health problems could be even worse in patients with low economy status and living in shelter houses. The aim of the research was to analyze the relationship of anxiety, depression, and macronutrient intake with nutritional status in cancer survivors undergoing chemotherapy at shelter houses. A total of 42 cancer patients aged 40-60 years old at shelter houses was recruited using consecutive sampling under a cross-sectional study design. Anxiety and depression data were taken using the Hospital Anxiety and Depression Scale (HADS) questionnaire, while energy, protein, fat, and carbohydrate data intakes were using Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ). The nutritional status data was examined based on Mid Upper Arm Circumference (MUAC). The data were analyzed using Pearson and Rank Spearman tests. Results of the study indicate that there were significant relationships between energy (p=0.040; r=0.318) and fat (p=0.001; r=0.490) with nutritional status. However, there was no relationship between anxiety and depression with macro-nutrient adequacy; also protein and carbohydrate intake with nutritional status. Anxiety and depression with nutritional also did not relate as evidenced by the value (p>0.05). To sum up, although there were no correlations between anxiety and depression with nutritional status, correlations occurred between energy and fat with nutritional status. Further research is suggested to analyze variables underlying anxiety and depression such as family support, stage, duration of diagnosis and frequency of chemotherapy so that these variables can be controlled.
A metabolism-related gene-based prognostic and immunotherapy model for hepatocellular carcinoma
Authors: Zhao Hai-chao , Liu Zi-ang , Chen Chang-zhou , Liu Lu , Song Huang-qin , Tian Yan-zhang , Zhao Haoliang 
Published: October 2022

Abstract
Metabolism-related genes (MRGs) have been confirmed to play an important role in the occurrence and development of hepatocellular carcinoma (HCC). We obtained 88 differentially expressed MRGs according to ROC analysis. The prognostic risk score was then calculated based on 12 MRGs via LASSO regression, and patients were divided into high- and low-risk group. Furthermore, the survival prognostic value of this model was further confirmed in Kaplan–Meier and ROC analysis. Mutations in 12 MRGs were analyzed using cBioPortal. Further analysis showed that MRGs copy number variations (CNVs) in the model were correlated with immune checkpoints (LSECtin and PD-L1) and immune cells. Furthermore, this predictive model was found to be sensitive to immune infiltration and had good predictive value for the expression of immune checkpoints. In conclusion, an MRGs-based HCC prediction model for HCC was established and its effectiveness was verified.
Seroprevalence of SARS-CoV-2 in patients with rheumatic diseases on disease modifying antirheumatic drugs and /or immunosuppressive medications from India: a multicentric study
Authors: Misra Ramnath , Bhattacharya Debdutta , Ahmed Sakir , Amin Sanjiv , Shobha Vineeta , Ghosh Alakendu , Pandya Sapan C , Parai Debaprasad , Padhan Prasanta , Priyadarshini Subhadra , Mohapatra Ipsa , Patro A Raj Kumar , Mohanty Ambika Prasad , Pati Sanghamitra 
Published: October 2022

Abstract
There is an uncertainty regarding the effect of the SARS-CoV-2 infection on patients with chronic rheumatic diseases who are on immunosuppressive drugs. We did a multicentric cross sectional seroprevalence study were conducted in five different cities of India prior to COVID-19 immunization. Patients with a diagnosis of rheumatic disease and on DMARDs were included. Relatives of the patients, preferably staying in the same household with no known rheumatic diseases served as controls (subjects without disease). Serum IgG antibodies to SARS-CoV-2 Receptor Binding Domain (RBD) of the spike protein and nucleoprotein (NP) was assayed. Eight hundred eighty-nine sera (subjects with disease = 379 and in subjects without disease = 510) were assayed. IgG antibodies to either RBD and/or NP were positive in 135 (36%) subjects with disease as compared to 196 (38%) in subjects without disease. The seroprevalence to RBD and NP varied between different cities but was not significantly different between subjects with and without disease in Mumbai, Ahmedabad, Bengaluru and Bhubaneswar. However, the occurrence of IgG antibodies to RBD was significantly (p < 0.05) lower in subjects with disease (28/65;43%) as compared to subjects without disease (42/65;65%) in Kolkata, where the positivity rate was lower in connective tissue disease group than in inflammatory arthritis group. Overall, patients with rheumatic diseases on DMARDs have IgG antibodies to RBD and NP of SARS-CoV-2 at a comparable level with that of subjects without disease, but the level of antibodies to RBD is lower in patients with connective tissue disease on immunosuppressive drugs in one centre.
Multimodal MEMS vibration energy harvester with cascaded flexible and silicon beams for ultra-low frequency response
Authors: Wang Xiaohong , Feng Haizhao , Bu Ling , Li Zhangshanhao , Xu Sixing , hu bingmeng , Xu Minghao , Jiang Siyao 
Published: October 2022

Abstract

Scavenging energy from ambient vibrations has become a promising energy supply for autonomous microsystems. However, restricted by device size, most MEMS vibration energy harvesters have much higher resonant frequencies than environmental vibrations, which reduces scavenged power and limits applicable scenarios. Herein, we propose a MEMS multimodal vibration energy harvester with specifically cascaded flexible PDMS and zigzag silicon beams to lower the resonant frequency to Hertz level and to broaden the bandwidth simultaneously. A two-stage architecture is designed, in which the primary subsystem consists of suspended PDMS beams characterized by low Young’s modulus, and the secondary system consists of zigzag silicon beams. We also propose the PDMS lift-off process to fabricate the suspended flexible beams, a compatible microfabrication method with high yield and good repeatability. The fabricated MEMS energy harvester can operate at ultra-low resonant frequencies of 3 Hz and 23 Hz, achieving maximum normalized voltage density of 200 V/cm3/g2@ 3 Hz. The reasons for output power degradation in the low frequency range and the potential enhancement strategies are discussed. This work offers new insights for achieving MEMS scale energy harvesting with ultra-low frequency response.
A Study on Transboundary Governance of Marine Plastic Debris—the Case of an Adjacent Waters between China and Taiwan
Authors: Ma Hsiang-Yu , Kao Jui-Chung , KAO RUI HSIN , Chiang Nein-Tsu , Cho Cheng-Chung 
Published: October 2022

Abstract
This study aimed to construct a transboundary marine governance mechanism in the Kinmen-Xiamen Waters through literature review, field survey, in-depth interview, and expert opinion survey. The study finding that monsoons, ocean currents and tides are the main factors affecting the drift of marine debris in the Xiamen Sea area to the beaches of Kinmen. The marine debris mainly included marine plastic debris (MPD), bamboo and wood in Kinmen, and was documented impacting a variety of species, including thehorseshoe crab to marine mammals the IndoPacific dolphin. In addition, the problem of marine micro-plastic pollution is becoming increasingly worrisome, and hazardous to rare creatures in the Xiamen Sea area. The pollution sources of MPD in Xiamen Bay included coastal tourism activities, micro-plastic discharged from sewage treatment plants, plastic waste produced by lost and discarded marine aquaculture and plastic drifting terrestrial waste transported by from the Jiulong River Basin.
Monitoring vegetation changes in the dust center of Southwest Iran
Authors: Dinarvand Mehri , Sarab Sajad Alimahmodi , Arami Seyed Abdolhossein , Haidari Kohzad 
Published: October 2022

Abstract

An area equivalent to 26,000 hectares of the dust center of southwestern Iran, located in Khuzestan province, was stabilized between 2015 to 2021 in the form of a biological stabilization and water distribution program. For biological stabilization, Prosopis juliflora shrubs were used and irrigation was done with tankers or furrows at intervals. The objective of this study was to utilize remote sensing technologies, geographic information systems, and field investigation to determine the vegetation changes in two time periods in seven regions within the South West of Iran, during the years 2016 and 2021 (Before and after planting), to show the impact of the native planted species on the natural environment. As the processed images show, there have been wide fluctuations in vegetation in the study area from 2016 to 2021. The slope of changes was positive in all the investigated points. In the first year of the research, in some areas, no plant species were seen or they were very scattered, but in 2021, plant species such as Salsola jurdanica, Atriplex leucoclada, Aeloropus lagopoides, and Bienertia cycloptera were observed with a high percentage of coverage. Of course, it should be noted that the region has a good seed bank. The results of monitoring vegetation changes in the dust center of Southwest Iran (2016–2021), revealed that the irrigation method of seedling area and precipitation conservation structure has an effective role in species diversity of local vegetation in deserts or restoration of fragile rangelands.
The wider the gap between rich and poor, the higher the flood mortality
Authors: Lindersson Sara , Raffetti Elena , Rusca Maria , Brandimarte Luigia , Mård Johanna , Baldassarre Giuliano Di 
Published: October 2022

Abstract
Economic inequality is rising within many countries globally, and this can significantly influence social vulnerability to natural hazards. Through a global analysis of income inequality and flood disasters in middle- and high-income countries, we show that unequal countries tend to suffer higher flood fatalities. Based on our results, we argue that the increasingly uneven distribution of wealth deserves more attention within international disaster risk research and policy arenas.
A non-transcriptional function of YAP physically interacts with α-tubulin to stabilize the mitotic spindle and midbody structures through gaining the acetyl-α-tubulin in lung cancer cell
Authors: Chow Shu-Er , Hsu Chia-Chi , Yang Cheng-Ta , Meir Yaa-Jyuhn 
Published: October 2022

Abstract
The YES-associated protein (YAP), a member of the Hippo pathway, plays pivotal roles in several developmental processes and acts dual functions as a tumor suppressor and an oncogene. In the present study, we identified the non-transcriptional function of YAP acting as the microtubular scaffold protein to maintain the stability of the mitotic spindle and midbody through physically interacting with α-tubulin during mitotic progression. The interaction of YAP and α-tubulin was evident from the co-immunoprecipitation assays and their co-localization in the microtubular structure of the mitotic spindle and midbody in immunostainings. In YAP depletion, the reduction of ECT2, MKLP-1, and Aurora B is consistent with its function in assembling the microtubule-associated proteins. Further, the concomitantly waning α-tubulin and gaining acetyl-α-tubulin during YAP depletion, which occurred at the post-transcriptional level, suggests that YAP functions in maintaining the stability of the mitotic spindle and midbody for ensuring faithful chromosome segregation during mitotic division. Furthermore, the raised acetyl-α-tubulin in YAP depletion may serve as a lesion-halting mechanism in maintaining the microtubule structure. As the resultant multinuclearity and aneuploidy in YAP depletion, it unravels the tumor suppressor role of the transcription-independent function of YAP.
New Empirical Models for Flood Loss Prediction and Implications for the Coterminous United States
Authors: Pollack Adam , Wing Ian Sue , Pinter Nicholas , Nolte Christoph 
Published: October 2022

Abstract
Flood-loss estimates are needed for floodplain development and mitigation projects, for setting fair insurance rates, and for guiding climate adaptation policy. Currently, flood-loss models, including depth-damage functions (DDFs) widely used in the U.S., lack empirical validation commensurate with the geographic extent and diversity of structures and flood exposure over which these predictions are needed. Using data from 845,776 U.S. National Flood Insurance Program claims, we validate DDFs and create alternative models grounded in empirical data and validation. These alternative models more accurately predict average observed damages for many types of structures and hazard compared to current DDFs which omit important variables and interactions that drive observed losses. We find that a major bottleneck in flood-loss estimation is the development and validation of flood-loss models for both damaged and undamaged homes, a gap FEMA could help close.
Evaluation of the deformity of congenital proximal radioulnar synostosis by using a digital technique
Authors: Yang Chen , Liu Lu , Wei Qi-Pei , Bai Fan , Chen Shan-lin 
Published: October 2022

Abstract
Purpose: To find out the influence factors of the “forearm rotation angle” (FR) which related to the severity of CRUS.
Methods: We established 48 digital three-dimensional forearm bones models of 48 patients with congenital radioulnar synostosis (CRUS) classified as Cleary and Omer type 3. In total, 10 independent deformities involved in the CRUS complex deformity were measured. Pearson correlation analysis for each deformity was performed and multivariate linear regression analysis was also performed with FR as the dependent variable and the other deformities as the influential factors.
Results: The “dorsal angle of radius” (DAR) had the strongest correlation with the FR (0.601, P<0.01), the internal rotation angle of the radius (IRAR) has a moderate correlation with FR (0.552, P<0.01). A forearm deformity equation was established: FR=35.896+0.271 DAR+0.989 IRAR.
Conclusion: The results of this study and the forearm deformity equation may be significant in guiding clinical practice.
Level of Evidence: Level 4 Evidence.
Hypoxia-elicited exosomes promote the chemoresistance of pancreatic cancer cells by transferring lncROR via Hippo signaling
Authors: Wang Huizhi , Min Jingyu , Liu Junqiang , Xu Chunhui , Liu Yawen , Yu Zhengyue , Gong Aihua , Xu Min 
Published: October 2022

Abstract
Recent studies have found that hypoxia contributes to tumor progression and drug resistance via inducing exosomes secretion. However, the underlying mechanism of this resistance in pancreatic cancer remains to be explored. In this study, we explored the effect and molecular mechanisms of hypoxia-induced tumor-derived exosomes (Hexo) on stemness and gemcitabine (GEM) resistance in pancreatic cancer cells. Firstly, we discovered that hypoxia could promote the stemness and induce gemcitabine resistance in pancreatic cancer cells. Subsequently, we proved that exosomes secreted by pancreatic cancer cells under normoxic or hypoxic conditions can be transfected into tumor cells. And then, Hexo was demonstrated to promote the proliferation, stemness and Gem resistance of pancreatic cancer cells, as well as inhibit the apoptosis and the cell cycle arrest induced by gemcitabine. Finally, it was verified that Hexo could inactivate the Hippo/YAP pathway of pancreatic cancer cells by transferring exosomal lncROR. In summary, hypoxic tumor microenvironment could promote the stemness and induce gemcitabine resistance in pancreatic cancer cells. Mechanically, Hexo enhanced the stemness to promote chemoresistance of pancreatic cancer cells by transferring lncROR via Hippo signaling. Thus, exosomal lncROR may serve as a candidate target for pancreatic cancer chemotherapy.
Gentrification and Air Quality in a Large Urban County in the United States
Authors: Hutchings Hollis Elizabeth , Zhang Qiong , Grady Sue , Mabe Lainie , Okereke Ikenna C 
Published: October 2022

Abstract
Objectives: To determine the association of gentrification with changes in racial distribution and in air quality in each zip code of a large urban county over a 40 year period.
Design: This was a retrospective study over 40 years in a large urban county, using sociodemographic data and air quality data from the NHGIS and US EPA respectively. To assess gentrification, longitudinal analyses were performed to examine median household income, percent with a college education, median housing value, median gross rent and employment level. Racial distribution was evaluated in each zip code during the time period.
Results: Gentrification was associated with worsening of air quality and strongly associated with racial distribution. The most substantial gentrification occurred from 2010 to 2020, in which a specific cluster of adjacent zip codes in Detroit experienced intense gentrification and drop in percentage of African American residents.
Conclusions: Gentrification is associated with worsening pollution and air quality and associated with an increase in non-minority residents. This increased pollution is likely secondary to increases in traffic density and creation of buildings with increased emissions. Displaced residents do not get to experience the improvements in housing quality, accessibility to healthy foods and other benefits of gentrification.