bluuebunny/crossref_metadata_2025_split huggingface dataset:
The speech act of advising in teacher-teacher interaction
Authors: Salam El-Dakhs Dina Abdel 
Published: February 2022

Abstract
The current study aimed to examine how university teachers advise their fellow teachers with a focus on solicited advice. To this end, 60 university teachers who use English as a Lingua Franca (ELF) as the medium of their everyday communication completed 8 role-plays in which newly hired teachers sought the advice of their colleagues regarding work issues. The role-plays were recorded and transcribed in preparation for coding, which was conducted with the use of Martínez-Flor’s (2003) taxonomy of advising and Trosborg’s (1995) taxonomy of internal modifiers. External modifiers were also examined as they emerged in the data. The results showed that the participants mainly preferred the use of direct advising strategies while simultaneously attempting to cater for the interlocutors’ negative face. While the advising strategies were situation dependent, the effect of the social variables of the advisor’s gender/teaching experience and the advisee’s academic rank was minimal. The results are interpreted in light of the theoretical model of politeness and the literature on the speech act of advising and the use of ELF.
Climate Risks of the Transition to a Renewable Energy Society: The Need for Extending the Research Agenda
Authors: Aall Carlo , Wanvik Tarje , Dale Brigt 
Published: February 2022

Abstract
To reach the 1.5°–2° goal of the Paris Agreement, the speed of transition to a renewable energy society must increase significantly. Applying Perrow’s theory of societal risk, we argue that switching from a fossil-based energy system to a future 100% renewable energy system may increase climate risks. Reviewing policy and research literature, and interviewing key energy policy actors in Norway, we find that there is limited knowledge on this topic and that the knowledge that does exist suffers from several shortcomings. Climate risks are generally discussed by applying future climate to the current energy system and thus failing to consider climate vulnerabilities caused by the ongoing energy transition. Also, discussions are frequently limited to subsystem reflections as opposed to system reflections and mostly present supply-side perspectives as opposed to demand-side perspectives. Most of the policy actors conclude that a future 100% renewable energy system will mainly benefit from climate change and reduce rather than increase climate risks. A research agenda is proposed to gain a better understanding of how the ongoing energy transitions can affect climate risks, especially to address the potential that reducing the level of energy consumption, diversifying energy sources, and prioritizing short-traveled energy can have to reduce climate risk in high-consuming countries.

Significance Statement
Switching from a fossil-based to a mostly “climate driven” renewable energy system may increase climate risks, and rapid transitions may increase risks even more. Still, knowledge of such risks is limited and suffers from several shortcomings. Studies are generally applying future climate to current energy system conditions and thus failing to consider vulnerabilities caused by the ongoing transformation of the energy system. Studies so far are also often limited to analyzing only parts of the system and not the energy system as a whole, and they are aiming at the production side rather than the consumption side. Thus, they tend to conclude that the energy system will mainly benefit from climate change. To reduce climate risks, we claim the need to focus on energy consumption and short-traveled energy.
Equivalent Operative Outcomes for Emergency Colon Cancer Resections Among Acute Care Surgeons and Specialists in Colorectal Surgery
Authors: Cairns Ashley L. , Hess Alexis B. , Rieken Holly , Lin Nicholas , Rao Shambavi , Jee Yoonsun , Ashburn Jean H. , Miller Preston R. , Carmichael Samuel P. , Mowery Nathan T. 
Published: February 2022

Objectives Improved screening has decreased but not eliminated the need for emergent surgery for colon cancer (CC), many of which are performed by acute care surgery (ACS) surgeons. This retrospective review compares outcomes for CC resections on the ACS service to the surgical oncology and colorectal services (SO/CRS). Methods Retrospective review was performed for CC operations between 2014 and 2019. Data for margin status, cancer stage, number of lymph nodes dissected, time to medical oncology follow-up, and time to initiation of chemotherapy were collected. Patients with curative resection, who chose comfort care, presented on alternative services or with non-CC indications as well as those were lost to follow-up were excluded. Results 36 ACS patients and 269 SO/CRS patients underwent CC resections. Most ACS patients presented emergently compared to the SO/CC group (83.3% vs 1%, P < .05) as well as with more advanced tumor stage. There were no statistically significant differences for presence of metastatic disease, number of lymph nodes obtained, or time to post-surgical care (in days) and chemotherapy initiation (in days). 3 (8%) EGS patients had positive margins compared to 6 (2%) CRS/SO patients due to the presence of perforated tumors in the ACS group ( p < .05). There were no statistically significant differences in 30- day or 1-year mortality despite the emergent presentation of the ACS patients. Discussion These findings suggest that despite emergent presentation and advanced disease burden, ACS surgeons provide quality care to CC patients, both in the operating room and in coordination of care.
Inefficient Cooperation Under Stochastic and Strategic Uncertainty
Authors: Bruttel Lisa , Güth Werner , Nithammer Juri , Orland Andreas 
Published: February 2022

Stochastic uncertainty can cause coordination problems that may hinder mutually beneficial cooperation. We propose a mechanism of ex-post voluntary transfers designed to circumvent these coordination problems and ask whether it can increase efficiency. To test this transfer mechanism, we implement a controlled laboratory experiment based on a repeated Ultimatum Game with a stochastic endowment. Contrary to our hypothesis, we find that allowing voluntary transfers does not lead to an efficiency increase. We suggest and analyze two major reasons for this failure: first, stochastic uncertainty forces proposers intending to cooperate to accept high strategic uncertainty, which many proposers avoid; second, many responders behave only incompletely conditionally cooperatively, which hinders cooperation in future periods. JEL-Classification: C78, C92, D74
The association between varicocele and other vascular diseases: A systematic review and meta-analysis
Authors: Chen Di , Luo Quanhai , Fan Wenji , Chen Changsheng , liu Gang 
Published: February 2022

Objective This study is aimed to evaluate the association between varicocele and other vascular diseases through a systematic reviews and meta-analyses. Material and methods We searched Cochrane Central Register of Controlled Trials, Embase, PubMed, and Web of Science for studies that reported varicocele and other vascular diseases published before 30 June 2021. The meta-analysis was performed by Revman V.5.2 to calculate the pooled odds ratios and corresponding 95% confidence intervals. Subsequently, the impact of publication bias was evaluated, and sensitivity analysis as performed to assess our results’ robustness. Results In total, seven case–control studies, including 803 varicocele cases and 727 controls, were included. Our meta-analysis results showed that the varicocele patients had a higher risk of saphenofemoral insufficiency when compared with the control group (odds ratio [OR]: 2.80; 95% confidence intervals [CIs]: 2.03, 3.84; p < 0.00001). Additionally, varicocele patients also had a higher risk of lower extremity venous insufficiency when compared with the control group (OR: 2.34; 95% CI: 1.58, 3.47; p < 0.0001). However, there was no statistical difference in hemorrhoid risk between both groups (OR: 1.13; 95% CI: 0.28, 4.59; p = 0.87). Conclusion Our study demonstrated that varicocele patients have higher risk of saphenofemoral and lower extremity venous insufficiencies but not the risk of hemorrhoids.
Beehive wind turbine: A new design for electric power generation in urban and semi-urban zones
Authors: Monzamodeth Román-Sedano A , Nicolás Iván Román-Roldán , Bernardo Hernández-Morales , Osvaldo Flores , Fermín Castillo , Bernardo Campillo 
Published: February 2022

A new wind turbine design for domestic use in urban and semi-urban areas has been studied to examine their implementation and efficiency. In this work, the development of a wind turbine, based on the beehive shape is proposed for possible domestic implementation in urban and semi-urban zones. A first prototype is presented and results of testing it in a mobile assembly are reported. The wind turbine was designed using CAD and to compute the air flow pressure distribution on the blades and assess the mechanical response of the turbine, computational fluid dynamics (CFD) and static structural simulations were performed. The CFD results showed pressure on all the wind turbine blades and a small pressure increase in the cavities generated by the beehive arrangement. On the other hand, the prototype was manufactured using a 3D printer and tested under working conditions on a mobile assembly in urban and semi-urban routes (freeway and highway, respectively). The revolutions per minute of the turbine and the relative wind velocity were measured and employed for structural simulations. The results demonstrated that the proposed beehive wind turbine is able to operate on urban and semi-urban areas. [Formula: see text]
Integration of Prostate Biopsy Results with Pre-Biopsy Multiparametric Magnetic Resonance Imaging Findings Improves Local Staging of Prostate Cancer
Authors: Caglic Iztok , Sushentsev Nikita , Shah Nimish , Warren Anne Y. , Lamb Benjamin W. , Barrett Tristan 
Published: February 2022

Purpose: To assess the added value of histological information for local staging of prostate cancer (PCa) by comparing the accuracy of multiparametric MRI alone (mpMRI) and mpMRI with biopsy Gleason grade (mpMRI+Bx). Methods: 133 consecutive patients who underwent preoperative 3T-MRI and subsequent radical prostatectomy for PCa were included in this single-centre retrospective study. mpMRI imaging was reviewed independently by two uroradiologists for the presence of extracapsular extension (ECE) and seminal vesicle invasion (SVI) on a 5-point Likert scale. For second reads, the radiologists received results of targeted fused MR/US biopsy (mpMRI+Bx) prior to re-staging. Results: The median patient age was 63 years (interquartile range (IQR) 58-67 years) and median PSA was 6.5 ng/mL (IQR 5.0-10.0 ng/mL). Extracapsular extension was present in 85/133 (63.9%) patients and SVI was present in 22/133 (16.5%) patients. For ECE prediction, mpMRI showed sensitivity and specificity of 63.5% and 81.3%, respectively, compared to 77.7% and 81.3% achieved by mpMRI+Bx. At an optimal cut-off value of Likert score ≥ 3, areas under the curves (AUCs) was .85 for mpMRI+Bx and .78 for mpMRI, P < .01. For SVI prediction, AUC was .95 for mpMRI+Bx compared to .92 for mpMRI; P = .20. Inter-reader agreement for ECE and SVI prediction was substantial for mpMRI (k range, .78-.79) and mpMRI+Bx (k range, .74-.79). Conclusions: MpMRI+Bx showed superior diagnostic performance with an increased sensitivity for ECE prediction but no significant difference for SVI prediction. Inter-reader agreement was substantial for both protocols. Integration of biopsy information adds value when staging prostate mpMRI.
Epidermal growth factor receptor-Mutated Non-small-cell Lung Cancer with Intracranial Progressions and Stable Extracranial Diseases Benefit from Osimertinib Regardless of T790M Mutational Status
Authors: Liao Jun , Huang Yihua , Gan Jiadi , Pang Lanlan , Ali Wael A. S. , Yang Yunpeng , Chen Likun , Zhang Li , Fang Wenfeng 
Published: February 2022

Objectives Osimertinib has exhibited promising central nervous system (CNS) efficacy in Epidermal growth factor receptor (EGFR)-mutated advanced non-small-cell lung cancer (NSCLC) patients. In real-world clinical practice, patients would turn to plasma genotyping or take osimertinib blindly after CNS progression on previous tyrosine kinase inhibitors (TKIs). However, the efficacy of osimertinib in those patients according to their T790M mutational status has not been explored. Materials and methods Twenty-five patients who received osimertinib due to intracranial progressions with stable extracranial diseases after early-generation EGFR-TKI treatment were collected from 1032 EGFR-mutated NSCLC. Plasma samples were analyzed for EGFR mutations using next-generation sequencing (NGS) or polymerase chain reaction (PCR). Results Among the 25 patients, 17 patients took plasma genotyping before osimertinib treatment with 8 patients EGFR T790M mutation-positive and the rest started osimertinib blindly. The median progression-free survival (PFS) was 8.0 months (95% confidence interval [CI]: 6.12-9.94) and median intracranial PFS (iPFS) was 14.4 months (95% CI: 7.27-21.59) for the total population. No statistical difference was found in PFS and iPFS among patients with different EGFR T790M mutational statuses. Intracranial disease control rate (DCR) was 100.0% for 14 patients with evaluable intracranial lesions despite different T790M mutational statuses. DCR for extracranial lesions and overall lesions were 100.0%, 66.7%, and 87.5% for patients with T790M, no T790M, and unknown T790M mutational status, respectively. Conclusion For EGFR-mutated NSCLC patients with only intracranial progressions after previous TKI treatments, osimertinib is a promising treatment option regardless of T790M mutational status from plasma genotyping.
Safety and Efficacy Evaluation of Antithrombotic Therapy with Rivaroxaban and Clopidogrel After PCI in Chinese Patients
Authors: Bai Long , Yang Xiao-hong , Zhou Ya-qing , Cui Xiao-ran , Fu Ling-zhi , Zhang Ji-dong 
Published: February 2022

Objective To investigate the efficacy and safety of the antithrombotic therapy using the oral anticoagulant rivaroxaban and clopidogrel in Chinese patients with acute coronary syndrome complicated with atrial fibrillation after percutaneous coronary intervention. Methods A total of 100 patients were selected. Patients were randomly divided into two groups: the treatment group (rivaroxaban group) received a therapy of rivaroxaban and clopidogrel. The control group (warfarin group) receivied a combined treatment of warfarin, clopidogrel, and aspirin. The primary outcome endpoint was evaluated based on the adverse cardiac and cerebrovascular events within 12 months. Results A total of 8 (8.00%) main adverse cardiac and cerebrovascular events occurred during the 12 months of follow-up, including 5 (9.80%) in the warfarin group and 3 (6.10%) in the rivaroxaban group. The risk of having main adverse cardiac and cerebrovascular events in the two groups was comparable (P = 0.479). A total of 9 patients (9.00%) were found to have bleeding events, among which 8 patients (15.7%) were in the warfarin group, whereas only 1 patient (2.00%) was in the rivaroxaban group. Therefore, the risk of bleeding in the warfarin group was significantly higher than that in the rivaroxaban group (P = 0.047). Conclusions In Chinese patients with acute coronary syndrome complicated with atrial fibrillation, the efficacy of the dual therapy of oral anticoagulant rivaroxaban plus clopidogrel after percutaneous coronary intervention was similar to that of the traditional triple therapy combined with warfarin, aspirin and clopidogrel, but it has a better safety property, which has potential to widely apply to antithrombotic therapy after PCI
Lipegfilgrastim may cause hyperleukocytosis
Authors: Hannarici Zekeriya , Yılmaz Ali , Buyukbayram Mehmet Emin , Turhan Aykut , Tekin Salim Başol , Bilici Mehmet 
Published: February 2022

Introduction Granulocyte colony-stimulating factors (G-CSF) are utilized both in the treatment and prophylaxis of chemotherapy-induced neutropenia. Lipegfilgrastim is a long-acting G-CSF. Albeit it provides ease of administration compared to short-acting GCSFs, some lipegfilgrastim-related adverse events may occur. Bone pain, widespread body pain, and feeling of fever are among common adverse effects, while rare but more serious adverse effects such as leukocytosis, spleen rupture, interstitial pneumonia, acute respiratory distress syndrome, capillary leak syndrome, hypokalemia, and glomerulonephritis may occur as well. Case report We reported a case of hyperleukocytosis that developed due to prophylactic administration of lipegfilgrastim following the first course of neoadjuvant pertuzumab (840–420 mg), trastuzumab (8–6mg/kg), and docetaxel (75 mg/m2) in a 45-year-old female patient with a diagnosis of breast invasive ductal carcinoma. The patient, who presented with weakness, loss of appetite, and oral intake disorder, had elevated white blood cell (WBC), lactate dehydrogenase (LDH), and uric acid levels in her test results. Peripheral smear (PS) had a left shift. Management and outcome Intravenous 0.9% NaCl and peroral allopurinol were started to be administered to the patient. On the ninth day of hospitalization, the patient's clinical manifestation improved, and her WBC, LDH, uric acid, and PS returned to normal. Besides, the progression to tumor lysis syndrome (TLS) was prevented by appropriate hydration and allopurinol treatment. In subsequent chemotherapies (CTs), lipegfilgrastim was discontinued and filgrastim was started. The patient whose hyperleukocytosis did not recur was operated on following neoadjuvant CT. The patient's routine follow-up continues without any problems. Discussion Although lipegfilgrastim-induced hyperleukocytosis has not been reported in the literature, it should be borne in mind that hyperleukocytosis and related complications may occur, as in our case.
Effect of peripheral intravenous catheter type and material on therapy failure in a neonatal population
Authors: van Rens Matheus FPT , Hugill Kevin , Mahmah Mohamad Adnan , Francia Airene LV , van Loon Fredericus HJ 
Published: February 2022

Background: In neonatal settings vascular access devices are essential for treatment. However, their use is not without risks. The design and materials of peripheral vascular access devices have been evaluated amongst adult populations, but contemporary studies in neonatal settings are scant. Purpose/outcome measures: This research describes the prevalence of peripheral intravenous catheter failure related to three different catheter types with the intent to identify modifiable risks that might be used to evaluate device efficacy, innovate neonatal practice, and support future policy developments. Method and setting: This was a retrospective observational analysis of routinely collected anonymized intravenous therapy related data. The study was carried out at the tertiary neonatal intensive care unit (112 beds) of the Women’s Wellness and Research Center of Hamad Medical Corporation, Doha, Qatar. Participants: Neonates who were admitted to the unit requiring intravenous treatment wherefore peripheral intravenous cannulation was indicated, were included in this study. Results: The use of different type of catheters resulted in significantly less therapy failures as phlebitis and increased dwell time, compared with the control groups. This remains significant after adjusting for age at insertion, gestational age, birth weight, and catheter type. Conclusions: The study’s findings are in accord with international literature concerning adult and pediatric patients concerning the superiority of PUR over PTFE catheters with respect to the risk of phlebitis and longer dwell times. However, the risk of failure of therapy did not differ between catheters. This finding is reassuring and supports practitioner judgment when selecting peripheral catheter devices.
Tissue damage detected by quantitative gradient echo MRI correlates with clinical progression in non-relapsing progressive MS
Authors: Xiang Biao , Brier Matthew R , Kanthamneni Manasa , Wen Jie , Snyder Abraham Z , Yablonskiy Dmitriy A , Cross Anne H 
Published: February 2022

Background: Imaging biomarkers of progressive multiple sclerosis (MS) are needed. Quantitative gradient recalled echo (qGRE) magnetic resonance imaging (MRI) evaluates microstructural tissue damage in MS. Objective: To evaluate qGRE-derived R2t* as an imaging biomarker of MS progression compared with atrophy and lesion burden. Methods: Twenty-three non-relapsing progressive MS (PMS), 22 relapsing-remitting MS (RRMS), and 18 healthy control participants underwent standard MS physical and cognitive neurological assessments and imaging with qGRE, FLAIR, and MPRAGE at 3T. PMS subjects were tested clinically and imaged every 9 months over 45 months. Imaging measures included lesion burden, atrophy, and R2t* in cortical gray matter (GM), deep GM, and normal-appearing white matter (NAWM). Longitudinal analysis of clinical performance and imaging biomarkers in PMS subjects was conducted via linear models with subject as repeated, within-subject factor. Relationship between imaging biomarkers and clinical scores was assessed by Spearman rank correlation. Results: R2t* reductions correlated with neurological impairment cross-sectionally and longitudinally. PMS patients with clinically defined disease progression ( N = 13) showed faster decrease of R2t* in NAWM and deep GM compared with the clinically stable PMS group ( N = 10). Importantly, tissue damage measured by R2t* outperformed lesion burden and atrophy as a biomarker of progression during the study period. Conclusion: qGRE-derived R2t* is a potential imaging biomarker of MS progression.
A Survivorship Educational Tool for Latino Adolescent and Young Adult Cancer Survivors
Authors: Casillas Jacqueline N. , Bolano Carl , Schwartz Lindsay F. , Ganz Patricia A. , Kahn Katherine , Stuber Margaret , Bastani Roshan , Morales Sonia , Macadangdang Joshua , Lidington Emma K. , Quintana Karla , Gonzalez Amri , Casas Esther , Barboa Elvia 
Published: February 2022

Background Low receipt of survivorship care by Latino adolescent and young adult (AYA) cancer survivors necessitates development of age-appropriate and culturally tailored interventions aimed at increasing their perceived need for survivorship care. Method This study describes the development and acceptability testing of a culturally tailored intervention, a photonovela, as part of a community-partnered participatory research (CPPR) project. A four-step approach to the photonovela’s development was implemented: (a) literature review, (b) RAND-modified Delphi method, (c) photonovela booklet development, and (d) photonovela acceptability testing through focus groups. Using the CPPR approach, community and academic experts and members worked together at all stages of this project to identify educational domains for the photonovela and ensure that community views and scientific knowledge were equally represented. Results Cancer survivors and their families described the photonovela as entertaining and relatable. Its story positively reflected their own experiences, and they connected strongly with its characters. Acceptability testing of the photonovela played a significant role in its final script and content, and provided additional new insights into understanding survivorship care perspectives for Latino AYA survivors and their families. Conclusion Equal and shared community and academic involvement through CPPR is essential in identifying unique needs and developing culturally acceptable educational interventions for Latino AYA cancer survivors. The photonovela was seen as an important educational resource in enhancing knowledge and increasing perceived need for survivorship care in this population.