bluuebunny/crossref_metadata_2025_split huggingface dataset:
Probabilistic assessment of induced seismicity at the Alberta No. 1 geothermal project site
Authors: Yaghoubi Ali , Hickson Catherine J. , Leonenko Yuri , Dusseault Maurice B. 
Published: October 2022

Alberta No. 1 (ABNo1) is a geothermal project targeting deep carbonate, conglomerates, and sandstone formations in a potential production and injection zone for geothermal energy exploitation within the Municipal District of Greenview south of Grande Prairie, Alberta, Canada. In geothermal systems without a steam fraction (typically systems under 170 °C), rapid widespread pore pressure changes and slow temperature changes have led to increased deviatoric stresses, resulting in induced seismicity. A concern for the ABNo1 Geothermal Project is that anthropogenic seismicity from oil, gas, and well field fluid injection has created felt events in Alberta. Thus, at the beginning of this type of project, it is prudent to review the potential for induced seismicity. In this study, a geomechanical study of the Leduc and Granite Wash Formations, two potential geothermal fluid exploitation zones, has been undertaken based on borehole geophysics and regional injection-induced earthquake data. Determining subsurface properties such as state of stress, pore pressure, and fault properties, however, poses uncertainties in the absence of actual data from the target formations. Geomechanical analysis results (with associated uncertainties) are used to assess the potential for injection-induced earthquakes. A Monte Carlo probability analysis is employed to estimate the likelihood of slippage of the known faults close to the ABNo1 Geothermal Project. A cumulative distribution function of the critical pore pressure on each fault is derived from the local tectonic stress state and Mohr–Coulomb shear parameter analyses. The resultant probabilistic fault stability maps can serve as a baseline for future fluid injection projects in the region including wastewater disposal, hydraulic fracture stimulation, CO2sequestration, as well as geothermal energy extraction.
Organoleptic Quality Attributes and Their Association with Morphological Traits in Arabica Coffee (Coffea arabica L.) Genotypes
Authors: Merga Sakata Wakuma , Gebreselassie Abtew Wosene , Garedew Weyessa 
Published: October 2022

Arabica coffee is an essential crop in the national economy of Ethiopia. There is little information available about the cup quality profile of Teppi coffee, despite several sites across the country having conducted research on the organoleptic properties of various coffee types. Therefore, an experiment was conducted to determine the quality attributes of the genotypes and correlate their inherited quality with morphological traits. The experiment was superimposed on five-year-old plants of 17 coffee genotypes during the 2018 cropping season at Teppi and Gemadro sites. Using the wet processing method, six kilograms of red coffee cherries were carefully harvested, processed, and sun dried to a moisture content of 10.5% to 11.0%. To obtain the necessary number of replications, each sample was divided into three, and three cups for each sample were prepared for the tasting sessions. Organoleptic quality attributes were scored using the standard established. The analysis of variance for aromatic quality, acidity, flavor, and overall cup quality showed a highly significant difference (

P

= 0.01) among the tested coffee genotypes. All of the organoleptic quality attributes evaluated showed a no significant correlation with morphological traits like body (r = −0.11) and hundred-bean weight and, flavor (r = −0.1) and bean thickness. However, there was a strong correlation between organoleptic quality attributes like flavor (r = 0.95

∗
∗

) and acidity (r = 0.94

∗
∗

), demonstrating that any organoleptic characteristic is an important element in beverage quality. It is challenging to simultaneously choose for cup quality and bean physical features because there were no significant correlations between organoleptic quality and these traits. In this study, genotype 3/8 showed outstanding performance across locations for all organoleptic quality attributes, which can be used in the Arabica coffee-breeding program.
Loss of LOXL2 Promotes Uterine Hypertrophy and Tumor Progression by Enhancing H3K36ac-Dependent Gene Expression
Authors: Lu Xufeng , Xin Dazhuan E. , Du Juanjuan K. , Zou Quanli C. , Wu Qian , Zhang Yanan S. , Deng Wenhai , Yue Jicheng , Fan Xing S. , Zeng Yuanyuan , Cheng Xiaju , Li Xue , Hou Zhaoyuan , Mohan Man , Zhao Ting C. , Lu Xiaomei , Chang Zhijie , Xu Liyan , Sun Yu , Zu Xiongbing , Zhang Yu , Chinn Y. Eugene 
Published: October 2022

Abstract

Lysyl oxidase-like 2 (LOXL2) is a member of the scavenger receptor cysteine-rich (SRCR) repeat carrying LOX family. Although LOXL2 is suspected to be involved in histone association and chromatin modification, the role of LOXL2 in epigenetic regulation during tumorigenesis and cancer progression remains unclear. Here, we report that nuclear LOXL2 associates with histone H3 and catalyzes H3K36ac deacetylation and deacetylimination. Both the N-terminal SRCR repeats and the C-terminal catalytic domain of LOXL2 carry redundant deacetylase catalytic activity. Overexpression of LOXL2 markedly reduced H3K36 acetylation and blocked H3K36ac-dependent transcription of genes, including c-MYC, CCND1, HIF1A, and CD44. Consequently, LOXL2 overexpression reduced cancer cell proliferation in vitro and inhibited xenograft tumor growth in vivo. In contrast, LOXL2 deficiency resulted in increased H3K36 acetylation and aberrant expression of H3K36ac-dependent genes involved in multiple oncogenic signaling pathways. Female LOXL2-deficient mice spontaneously developed uterine hypertrophy and uterine carcinoma. Moreover, silencing LOXL2 in cancer cells enhanced tumor progression and reduced the efficacy of cisplatin and anti-programmed cell death 1 (PD-1) combination therapy. Clinically, low nuclear LOXL2 expression and high H3K36ac levels corresponded to poor prognosis in uterine endometrial carcinoma patients. These results suggest that nuclear LOXL2 restricts cancer development in the female reproductive system via the regulation of H3K36ac deacetylation.

Significance:
LOXL2 loss reprograms the epigenetic landscape to promote uterine cancer initiation and progression and repress the efficacy of anti–PD-1 immunotherapy, indicating that LOXL2 is a tumor suppressor.
A Randomized Multi-institutional Phase II Trial of Everolimus as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck
Authors: Nathan Cherie-Ann O. , Hayes D. Neil , Karrison Theodore , Harismendy Olivier , Flores José M. , Moore-Medlin Tara , Vokes Everett E. , Gutkind J. Silvio , Neupane Prakash , Mills Glenn , Sargi Zoukaa , Seiwert Tanguy , Grilley-Olson Juneko , Day Terry , Gillison Maura , Wade James L. , Feldman Lawrence , Jha Gautam , Kozloff Mark , O'Leary Miriam , Worden Francis P. , Cohen Ezra E.W. 
Published: October 2022

Abstract

Purpose:
Investigate whether adjuvant everolimus, an mTOR inhibitor, improves progression-free survival (PFS) in advanced-stage head and neck squamous cell carcinoma (HNSCC) and provide outcomes related to correlative biological factors associated with disease control.

Patients and Methods:
This was a prospective, randomized, double-blind phase II trial of patients with advanced-stage HNSCC from 13 institutions who were confirmed disease-free post-definitive therapy and enrolled between December 2010 and March 2015. Patients received adjuvant everolimus or placebo daily (10 mg, oral) for a maximum of 1 year. p16 IHC as a surrogate marker for human papillomavirus infection and whole-exome sequencing were performed. Cox proportional hazard models estimated hazard rates. Log-rank tests evaluated differences in survival. The primary endpoint was PFS. Secondary endpoints and objectives included overall survival (OS) and toxicity assessment.

Results:
52 patients [median (range) age, 58 (37–76) years; 43 men (83%), 9 women (17%)] were randomized to placebo (n = 24) or everolimus (n = 28). PFS favored everolimus, but was not significant [log-rank P = 0.093; HR = 0.44; 95% confidence interval (CI), 0.17–1.17]. There was no difference in OS (P = 0.29; HR = 0.57; 95% CI, 0.20–16.2). Everolimus resulted in significant improvement in PFS for p16-negative patients (n = 31; P = 0.031; HR = 0.26; 95% CI, 0.07–0.97), although subgroup analysis showed no difference for p16-positive patients (n = 21; P = 0.93). Further, PFS was significantly higher in TP53-mutated (TP53mut) patients treated with everolimus compared with placebo (log-rank P = 0.027; HR = 0.24; 95% CI, 0.06–0.95). No treatment difference was seen in patients with TP53 wild-type tumors (P = 0.79).

Conclusions:
p16-negative and TP53mut patients may benefit from adjuvant treatment with everolimus.
Effects of Pulsed Electric Fields on the Coronary Arteries in Swine
Authors: Ladejobi Adetola , Christopoulos Georgios , Tan Nicholas , Ladas Thomas P. , Tri Jason , van Zyl Martin , Yasin Omar , Sugrue Alan , Khabsa Mariam , Uecker Darrin R. , Connolly Richard J. , Danitz David J. , DeSimone Christopher V. , Killu Ammar M. , Maor Elad , Holmes David , Asirvatham Samuel J. , Del-Carpio Munoz Freddy 
Published: October 2022

Background:
Previous animal studies have shown no significant vascular injury from pulsed electrical field (PEF) ablation. We sought to assess the effect of PEF on swine coronary arteries.

Methods:
We performed intracoronary and epicardial (near the coronary artery) PEF ablations in swine pretreated with dual antiplatelet and antiarrhythmic therapy. Intracoronary PEF was delivered using MapiT catheters (Biotronik, Berlin), whereas epicardial PEF was delivered using EPT catheters (Boston Scientific, MA). PEF pulse duration was microseconds (Nanoknife 3.0, Angio Dynamics, NY) or nanoseconds (CellFX, Pulse Biosciences, CA).

Results:

We performed 39 intracoronary ablations in 10 swine and 20 epicardial-pericoronary ablations in 4 separate swine. Intracoronary PEF was delivered at higher energy compared with epicardial PEF (46 [interquartile range, IQR 20–85] J versus 10 [IQR 10–11] J,
P
< 0.01). Reversible coronary spasm occurred in 49% intracoronary ablations and 45% epicardial ablations (
P
=0.80). At the end study, fixed coronary stenosis was demonstrated in 44% intracoronary ablations (80% for microsecond PEF and 18% for nanosecond PEF) and 0% epicardial ablations. Visible hemorrhagic and/or fibrotic myocardial lesions were observed at necropsy with similar frequency between intracoronary and epicardial PEF (45% versus 50%,
P
=0.70). Nanosecond PEF (49 ablations in 11 swine), when compared with microsecond PEF (10 intracoronary ablations in 3 swine), resulted in lower energy delivery (21 [IQR 10–46] J versus 129 [IQR 24–143] J,
P
=0.03) and less incidence of fixed coronary stenosis (18% versus 80%,
P
=0.04).

Conclusions:
In the swine model, intracoronary PEF resulted both in significant coronary spasm and fixed coronary stenosis. Epicardial PEF, delivered at lower energy, resulted in reversible spasm but no fixed coronary stenosis.
Relationship Between Preexisting Cardiovascular Disease and Death and Cardiovascular Outcomes in Critically Ill Patients With COVID-19
Authors: Vasbinder Alexi , Meloche Chelsea , Azam Tariq U. , Anderson Elizabeth , Catalan Tonimarie , Shadid Husam , Berlin Hanna , Pan Michael , O’Hayer Patrick , Padalia Kishan , Blakely Pennelope , Khaleel Ibrahim , Michaud Erinleigh , Huang Yiyuan , Zhao Lili , Pop-Busui Rodica , Gupta Shruti , Eagle Kim , Leaf David E. , Hayek Salim S. ,   for the STOP-COVID Investigators‡
Published: October 2022

Background:
Preexisting cardiovascular disease (CVD) is perceived as a risk factor for poor outcomes in patients with COVID-19. We sought to determine whether CVD is associated with in-hospital death and cardiovascular events in critically ill patients with COVID-19.

Methods:
This study used data from a multicenter cohort of adults with laboratory-confirmed COVID-19 admitted to intensive care units at 68 centers across the United States from March 1 to July 1, 2020. The primary exposure was CVD, defined as preexisting coronary artery disease, congestive heart failure, or atrial fibrillation/flutter. Myocardial injury on intensive care unit admission defined as a troponin I or T level above the 99th percentile upper reference limit of normal was a secondary exposure. The primary outcome was 28-day in-hospital mortality. Secondary outcomes included cardiovascular events (cardiac arrest, new-onset arrhythmias, new-onset heart failure, myocarditis, pericarditis, or stroke) within 14 days.

Results:
Among 5133 patients (3231 male [62.9%]; mean age 61 years [SD, 15]), 1174 (22.9%) had preexisting CVD. A total of 1178 (34.6%) died, and 920 (17.9%) had a cardiovascular event. After adjusting for age, sex, race, body mass index, history of smoking, and comorbidities, preexisting CVD was associated with a 1.15 (95% CI, 0.98–1.34) higher odds of death. No independent association was observed between preexisting CVD and cardiovascular events. Myocardial injury on intensive care unit admission was associated with higher odds of death (adjusted odds ratio, 1.93 [95% CI, 1.61–2.31]) and cardiovascular events (adjusted odds ratio, 1.82 [95% CI, 1.47–2.24]), regardless of the presence of CVD.

Conclusions:
CVD risk factors, rather than CVD itself, were the major contributors to outcomes in critically ill patients with COVID-19. The occurrence of myocardial injury, regardless of CVD, and its association with outcomes suggests it is likely due to multiorgan injury related to acute inflammation rather than exacerbation of preexisting CVD.

Registration:

NCT04343898;
https://clinicaltrials.gov/ct2/show/NCT04343898
.
Residual Risk of Trimethylamine‐N‐Oxide and Choline for Stroke Recurrence in Patients With Intensive Secondary Therapy
Authors: Xue Jing , Xu Jie , Zhao Mingming , Jin Aoming , Cheng Aichun , Jiang Xue , Li Ke , Lin Jinxi , Meng Xia , Li Hao , Zheng Lemin , Wang Yongjun 
Published: October 2022

Background
Trimethylamine N‐oxide (TMAO) contributes to cardiovascular disease through its prothrombotic, proatherothrombotic, and proinflammatory effects. We aimed to evaluate whether residual risk of recurrent stroke of TMAO and its precursor choline remain among patients who received dual‐antiplatelet therapy and intensive lipid‐lowering therapy and with a low inflammation level (high‐sensitivity C‐reactive protein <2 mg/L on admission).

Methods and Results
Patients with ischemic stroke or transient ischemic attack were enrolled from the CNSR‐III (Third China National Stroke Registry) in China. Plasma TMAO and choline concentrations at baseline were measured in 9793 participants using liquid chromatography–mass spectrometry. The primary outcome was a new stroke within 1 year. Multivariable‐adjusted hazard ratios were calculated using Cox regression models to investigate the associations of TMAO and choline with stroke recurrence. Among all patients, elevated TMAO and choline levels were associated with an increased risk of recurrent stroke (adjusted hazard ratios, 1.28 [95% CI, 1.12–1.45]; and 1.50 [95% CI, 1.32–1.71], respectively). Moreover, elevated TMAO and choline levels were associated with an increased risk of recurrent stroke among patients who received dual‐antiplatelet therapy (1.65 [95% CI, 1.28–2.13]; and 1.70 [95% CI, 1.32–2.19], respectively), intensive lipid‐lowering therapy (1.49 [95% CI, 1.15–1.94]; and 1.49 [95% CI, 1.15–1.92], respectively), with high‐sensitivity C‐reactive protein <2 mg/L (1.39 [95% CI, 1.14–1.69]; and 1.88 [95% CI, 1.53–2.30], respectively), and concurrently received dual‐antiplatelet therapy, intensive lipid‐lowering therapy and with high‐sensitivity C‐reactive protein <2 mg/L (3.57 [95% CI, 1.73–7.38]; and 2.19 [95% CI, 1.16–4.16], respectively).

Conclusions
TMAO and choline were risk factors for recurrent stroke independent of dual‐antiplatelet therapy, intensive lipid‐lowering therapy at discharge, and low inflammation on admission.
Dig If You Will the Picture…: Reading Prince's Semiotic World
Authors: Toppins Aggie 
Published: October 2022

Abstract
Prince Rogers Nelson (1958–2016) was an innovative American musician whose life and work defied categorization. His music combined the spiritual with the sexual while spanning funk, rhythm and blues, soul, rock and roll, and pop genres. Prince embraced nonbinary gender performance and, as a Black artist of enormous celebrity, exemplified what W. E. B. Du Bois named double-consciousness: a sensibility gained from looking at oneself through the eyes of others; a “two-ness” derived from being both American and Black. Prince used multivalent signs, symbols, and codes to craft an enigmatic personal mythology. In this essay, I use Roland Barthes's poststructuralist theory and Stuart Hall's writing on stereotypes to examine Prince's semiotic world. By studying recurring motifs in his lyrics, fashion, and visual communication design, I show that Prince's signifying practices constitute a sensual text that, through illegibility, catalyzed emancipatory cultural expressions.
Supply-Side Climate Policies in Major Oil-Producing Countries: Norway’s and Canada’s Struggles to Align Climate Leadership with Fossil Fuel Extraction
Authors: Harrison Kathryn , Bang Guri 
Published: October 2022

AbstractThis article considers the puzzle of Norway and Canada, two countries that have adopted ambitious Paris Agreement targets yet are also major fossil fuel exporters. To date, both countries have taken full advantage of the international convention that assigns responsibility only for emissions within a country’s borders. However, climate activists, First Nations, and green politicians increasingly have challenged fossil fuel production via campaigns centered on issues salient to voters in nonproducing regions: opposing new exploration licenses in Norway and pipelines in Canada. While supply-side campaigns have sometimes succeeded in ending expansion, neither country has seriously entertained restricting current production. We attribute these outcomes to continued public support for fossil fuel–driven prosperity; institutions that assign responsibility for production and climate to different government agencies; and the success of counternarratives that unilateral supply restrictions are futile, prosperity from petroleum exports will fund domestic clean-energy transitions, and gas exports advance global climate action.
Recasting the Role of Citizens in Diplomacy and Foreign Policy: Preliminary Insights and a New Research Agenda
Authors: Geis Anna , Opitz Christian , Pfeifer Hanna 
Published: October 2022

Summary
Over the last decade, relations between the state and its citizens have changed in the fields of diplomacy and, more generally, foreign policy in some Western democracies. Both sides have begun to transform their roles through novel formats of citizen dialogue and participation. The full breadth and depth of these phenomena remain understudied, despite the fact that they constitute an important catalyst of the apparent ‘societisation’, or even further democratisation, of diplomacy. Based on our analyses of participatory formats in German diplomacy, we offer insights into the transformative potential of this development and discuss to what extent it simultaneously perpetuates unequal power relations. In order to further scrutinise these preliminary hypotheses on how the complex relationship between state diplomacy and domestic society is currently changing, we propose a new research agenda on citizen participation in foreign policy.
Unrealised promises and hollow claims: Australia’s failure to enact its international obligations under the CRPD for the education of students with disability
Authors: Malaquias Catia 
Published: October 2022

The adoption of the United Nations Convention on the Rights of Persons with Disabilities (CRPD) in 2006 and, in particular, Article 24 was a landmark in the struggle of people with disability for recognition of their fundamental human rights, including their right to education. As a legally binding treaty under international law, imposing obligations on States Parties that signed and ratified it (including Australia), it required those States Parties to bring their domestic legislation into conformity with their CRPD obligations. The Disability Discrimination Act 1992 (DDA), and the Disability Standards for Education 2005 (Standards) made under it, remain the principal Australian statutory protection of the rights of students with disability to access education on the basis of equality and non-discrimination even though the DDA and the Standards preceded the CRPD. This article explores the proposition that the DDA and the Standards do not adequately implement Australia’s international legal obligations in relation to the education of students with disability.Note: This article makes use of agreed or legally defined terms. These terms are presented in italics throughout.
Association between the IL-6 polymorphisms and coal workers’ pneumoconiosis in a Chinese Hui population
Authors: Xu Xiangzhao , Yin Jun , Zhang Junlong , Xu Shulan , Yang Yaowen , Hai Xiaoyu , Yu Yongsheng , Lu Ruirui , Liu Mingzhou 
Published: October 2022

Objective To determine whether polymorphisms in IL-6 and IL-12 contribute to the etiology of coal workers’ pneumoconiosis (CWP) in a Chinese Hui population, and to evaluate the efficacy and safety of high frequency oscillatory ventilation (HFOV) in the treatment of CWP. Introduction Genes and the environments interplay in the development of CWP, and the association between the potential functional polymorphisms in many genes and CWP have been reported. Methods We genotyped the IL-6-634C/G (rs1800796) and IL-12B-1188A/C (rs3212227) polymorphisms in a case-control study including 160 CWP patients and 150 dust-exposed control subjects of Chinese Hui population, and analyzed the associations between these genetic variants and CWP risk. We also evaluated the efficacy and safety of HFOV for whole lung lavage (WLL) in the treatment of CWP. Results Carrying the C allele of IL-6-634C/G (rs1800796) was associated with decreased risk of CWP ( p < 0.05). No significant differences in allele or genotype frequencies of IL-12B-1188A/C was found between the CWP cases and control subjects ( p > 0.05). Compared with CWP patients with routine WLL, CWP patients received HFOV showed better pulmonary functions. HFOV treatment also yield a significant higher efficient rate (97.50%) than WLL treatment (81.25%, p = 0.001). CWP patients receiving HFOV and WLL treatment both showed significantly increased serum contents of Clara cell protein 16 (CC16) and superoxide dismutase (SOD), and decreased serum contents of serum malonaldehyde (MDA). While the increasing of CC16 and SOD, and decreasing of MDA in patients receiving HFOV was more noticeable than patients receiving WLL. Conclusions Taking together, the −634C/G polymorphisms in IL-6 play a role in the etiology of CWP. HFOV, when applied in CWP patients, significant improves their pulmonary functions.