bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of antibiotic resistance profile of bacteria isolated from Ghaghara River, India
Authors: Ravi Nirdesh Kumar , Pal Arun Kumar , Soni Ramendra , Tripathi Pooja , Singhal Anjali , Jha Pawan Kumar , Tripathi Vijay 
Published: October 2022

Abstract
Excessive anthropogenic activities play a significant role in the emergence and dissemination of antibiotic resistance in urban streams and river sediment. The objectives of the present study were to investigate the antibiotic susceptibility profile, molecular detection of antibiotic resistance genes (ARGs), and identification of multidrug-resistant bacterial isolates in the mainstream and tributaries of the Ghaghara River. The obtained data indicated that the majority of the isolates were identified as Bacillus spp. (40%) followed by Klebsiella quasipneumoniae (20%), Exiguobacterium undae (13.33%). Most of the bacterial isolates were resistant against penicillin G (P) (24%), cefuroxime (CXM) (20%), amoxicillin (AMX) (18%), and ampicillin (AMP) (17%) in sediments samples, whereas penicillin G (27%), cefuroxime (CXM) and erythromycin (E) was 13%, AMP and cefaclor both showed 12% in water samples respectively. This study provides insight into the prevalence of multiple antibiotic-resistant bacterial diversity in the Ghaghara River and provides the route to disseminate the multidrug-resistant pathogens in the human and animal population through the aquatic environment.
Vaccination Against SARS-CoV-2 Protects from COVID-19-induced Endothelial
Dysfunction
Authors: Oikonomou Evangelos , Lampsas Stamatios , Souvaliotis Nektarios , Sarantos Savvas , Siasos Gerasimos , Poulakou Garyphallia , Lytra Thekla , Papamikroulis Georgios Angelos , Fountoulakis Nikolaos , Theofilis Panagiotis , Tsoukalas Dionysios , Gounaridi Maria Ioanna , Tsatsaragkou Aikaterini , Marinos Georgios , Tousoulis Dimitris , Vavuranakis Manolis 
Published: October 2022

Background:
Coronavirus Disease-19 (COVID-19) is implicated in endotheliitis which adversely affects cardiovascular events. The impact of vaccination with COVID-19 on the clinical outcome of patients is documented.

Objective:
To evaluate the impact of vaccination with COVID-19 on severe acute respiratory syndrome, coronavirus-2 (SARS-CoV-2) infection-related endothelial impairment.

Methods:
We enrolled 45 patients hospitalized for COVID-19 (either vaccinated or not against SARS-CoV-2). Clinical and laboratory data were collected, and brachial artery flow-mediated dilation (FMD) was evaluated. Subjects without COVID-19 were used as the control group.

Results:
There was no difference in age (64.7±7.5 years vs. 61.2±11.1 years vs. 62.4±9.5, p=0.28) and male sex (49% vs. 60% vs. 52%, p=0.71), between control subjects, vaccinated, and unvaccinated subjects with COVID-19 respectively. Of the patients with COVID-19, 44% were vaccinated against SARS-CoV-2. Unvaccinated COVID-19 patients had significantly impaired FMD compared to vaccinated COVID-19 patients and to Control subjects (2.05±2.41 % vs. 7.24±2.52 % vs. 7.36±2.94 %, p<0.001). Importantly, post hoc tests revealed that unvaccinated COVID-19 patients had significantly impaired FMD from both Vaccinated COVID-19 subjects (p<0.001) and form Control subjects (p<0.001). There was no difference in FMD between the control group and the vaccinated COVID-19 group (p=0.99).

Conclusion:
Hospitalized patients with COVID-19 present endothelial dysfunction in the acute phase of the disease. Endothelial function in unvaccinated patients with COVID-19 is impaired compared to control subjects as well compared to vaccinated patients with COVID-19. Vaccinated hospitalized subjects with COVID-19 do not show endothelial dysfunction, strengthening the protective role of vaccination against SARS-CoV-2.
Potential of Hesperidin in the Medicinal Field
Authors: Kumar Dharmendra , Dey Yadu Nandan , Pramanik Siddhartha Das , Singh Laliteshwar Pratap , Selvaraja Malarvili , Rajagopal Mogana 
Published: October 2022

Abstract:Hesperidin has gained major interest recently due to the outbreak of COVID-19. The traction has led to more research being conducted on the compound hesperidin. Recent studies have shown its anti-inflammatory and anti-viral attributes, which have beneficial effects on severe acute respiratory syndrome (SARS-CoV-2). Hesperidin has also shown unique effects on the protein of SARS-CoV-2, which lead to a good preventative measure for SARS-CoV-2. Hesperidin also causes a suppression of appetite, which helps to combat obesity through the release of cholecystokinin. Furthermore, hesperidin has shown cardioprotective properties, which cause an increase in plasma high-density lipoprotein levels and a decrease in plasma low-density lipoprotein levels. Hesperidin is also used in combination with the Japanese herb Rikkunshito, which has shown potential in a discovery of a new drug for gastrointestinal motility as hesperidin can depolarize pacemaker potential in interstitial cells of Cajal (ICC). The chemo-preventive effects of hesperidin are caused by its antioxidant effect, which may prevent tissue necrosis due to oxidative stress. The photo-protective effect of hesperidin can reduce the damage to the skin caused by UV rays. Hesperidin also possesses wound-healing properties.
An enigma of a country human dignity and utopic society
Authors: Dewantara Jagad Aditya , Syofianti Resti , Arifiyanti Fitria 
Published: October 2022

This paper to provide an explanation of the ideology that fights for human dignity and the formation of an imaginary or utopian society. The ideology adopted is the political ideology of anarchism and liberalism which both fight for equal rights and freedom. The two ideologies do have different histories or intricacies, but in this paper they will become a tool for human beings living in a country to maintain their dignity as owners of the right to life. And also the formation of an ideal that is often referred to as a utopia or an imaginary society in the midst of the development of increasingly advanced science and technology. The state is an enigma or a mystery. One of the mysteries is human dignity and utopian society which will be raised in this paper
PENGEMBANGAN MEDIA BERBANTUAN GEOGEBRA PADA SISTEM PERTIDAKSAMAAN LINEAR-KUADRAT DALAM MENINGKATKAN LITERASI MATEMATIKA SISWA
Authors: Kurniati Dian , Annisa Fitri , Murtikusuma Randi Pratama , Pambudi Didik Sugeng , Suwito Abi 
Published: October 2022

The purpose of this research is to develop a valid, practical, and effective interactive learning media assisted by GeoGebra. This study used the Thiagarajan (4-D) model which includes four stages, namely defining, designing, developing, and disseminating. The process of the four stages produced an interactive GeoGebra learning media, so students can explore practice questions related to inequalities material independently. The research subjects selected were students of class X Science 2 SMAN Arjasa Jember. The result of this development is a valid interactive learning media assisted by GeoGebra with a very high level of validity, included as practical criteria based on students' scores as media users, and is proven to be effective in improving students' mathematical literacy skills based on the N-Gain from the average pretest and posttest. This interactive learning media assisted by GeoGebra received positive responses from students as an interesting media that support students to understand the material during their sudy.
AN EXPLORATION STUDENT’S ERRORS IN SOLVING TRIGONOMETRIC RATIO PROBLEMS WITH ITS SCAFFOLDING
Authors: Kurniati Nurdiyah , Suhendra Suhendra , Priatna Nanang , Prabawanto Sufyani 
Published: October 2022

Trigonometry is an essential topic in learning mathematics, but in fact there are still identified student errors in solving trigonometry problems. Based on these problems, this study aims to describe students' errors in solving trigonometric problems, especially on the topic of trigonometric ratios and its scaffolding. This study uses a qualitative method with a case study approach. Collecting data through observation, tests and interviews. The subjects of this study were 35 students of class X in one of the senior high schools in Kutai Kartanegara Regency, East Kalimantan. The results of this study are that there are seven types of errors made by students in solving trigonometric ratio problems, namely: (1) error in understanding the concepts; (2) error in setting operation; (3) error in performing calculation; (4) error in applying the principle; (5) error in writing algorithm; (6) random response; and (7) error in drawing. Based on the results of these studies, it can be concluded that the forms of scaffolding that can be given are:explaining, reviewing, restructuring,and developing conceptual thinking. Trigonometri merupakan materi yang esensial dalam pembelajaran matematika, namun pada faktanya masih terdapat kesalahan-kesalahan siswa yang teridentifikasi dalam menyelesaikan masalah trigonometri. Berdasarkan permasalahan tersebut, penelitian ini bertujuan untuk mendeskripsikan kesalahan-kesalahan siswa dalam menyelesaikan masalah trigonometri khususnya pada topik rasio trigonometri beserta scaffoldingnya. Penelitian ini menggunakan metode kualitatif dengan pendekatan studi kasus. Pengumpulan data melalui observasi, tes dan wawancara. Subjek penelitian ini adalah 35 siswa kelas X di salah satu SMAN di Kabupaten Kutai Kartanegara, Kalimantan Timur. Hasil penelitian ini yakni terdapat tujuh jenis kesalahan yang dilakukan siswa dalam menyelesaikan masalah rasio trigonometri, yaitu: (1) kesalahan dalam memahami konsep; (2) kesalahan dalam menetapkan operasi; (3) kesalahan dalam melakukan perhitungan; (4) kesalahan dalam menerapkan prinsip; (5) kesalahan dalam menuliskan algoritma; (6) jawaban sembarang; dan (7) kesalahan dalam menggambar. Berdasarkan hasil penelitian tersebut, dapat disimpulkan bahwa bentuk scaffolding yang dapat diberikan yaitu explaining, reviewing, restructuring, dan developing conceptual thinking.
MATHEMATICAL LATERAL THINKING OBSTACLES IN SOLVING GEOMETRIC PROBLEMS BASED ON BRAIN DOMINANCE
Authors: Shodiq Lukman Jakfar , Juniati Dwi , Susanah Susanah 
Published: October 2022

Creative thinking was characterized by the emergence of new ideas which was an important skill for students. Lateral thinking was one way to grow new ideas. Generally, related research was carried out to see the thinking process and its level only with the results of the majority of low levels (especially in geometry problems), so further research was needed to find out what were the obstacles. This study aims to find mathematical lateral thinking barriers based on brain dominance. This research was a qualitative research with a case study approach. The instruments were a brain dominance test, creativity questions, and geometry questions for lateral thinking. Triangulation of data collection techniques was carried out To ensure data validity. Obtained two main subjects LCS and RCS. Analysis of subjects' answers, interview and observations transcripts were carried out by coding the inhibiting factors then analyzed by Toulmin's arguments analysis. We findings that left-brain dominant student experience ontogenic barriers in finding something new caused bounded by concepts and right-brain dominant student experience epistemological barriers in finding different ways cause bounded by context. Further research was needed with students who have high mathematical abilities and creativity to find out how to overcome lateral thinking obstacles.
Perencanaan Penerimaan Pajak Hotel Di Badan Pendapatan Daerah (BAPENDA) Kota Tasikmalaya Tahun 2020
Authors: Mardiana Degina , Ningrum Sinta , Sugandi Yogi Suprayogi 
Published: October 2022

Each region is competing in exploring every potential possessed by the region, one of which is local tax revenue, hotel taxes. One of them is in Tasikmalaya City. The hotel tax in the City of Tasikmalaya provides the second largest income after the restaurant tax for the City of Tasikmalaya, so the government is trying to explore the potential of the hotel tax through planning the potential for hotel taxes. The purpose of this study is to describe the planning process for the potential hotel tax in the City of Tasikmalaya in 2020. The research method used in this study is a mix method approach. The guidance theory used is planning with the five steps from Robbins and Coulter (2012). The data analysis technique used was quantitative data analysis techniques with the calculation of hotel tax potential, and qualitative data analysis techniques were through the stages of data reduction, data presentation and drawing conclusions. The results of this study indicate that planning the potential for hotel taxes at BAPENDA Tasikmalaya City uses the planning stages although in its implementation there are still obstacles in the planning process and extracting the potential for the hotel tax. Suggestions for this research are that there is a permanent system for storing data related to occupancy to review the hotel tax potential, make new innovations related to the Tasikmalaya City BAPENDA information system. Setiap daerahnya berlomba-lomba dalam menggali setiap potensi yang dimiliki oleh daerahnya, salah satunya melalui penerimaan pajak daerah yaitu pajak hotel. Salah satunya yaitu di Kota Tasikmalaya. Pajak hotel di Kota Tasikmalaya memberikan pemasukan terbesar ke dua setelah pajak restoran bagi Kota Tasikmalaya, sehingga pemerintah berupaya untuk menggali potensi dari pajak hotel tersebut melalui perencanaan potensi pajak hotel. Tujuan dari penelitian ini untuk memaparkan proses perencanaan potensi pajak hotel di Kota Tasikmalaya tahun 2020. Metode penelitian yang digunakan dalam penelitian ini yaitu pendekatan mix method. Guidance theory yang digunakan yaitu perencanaan dengan kelima langkah dari Robbins and Coulter (2012). Teknik analisis data yang digunakan teknik analisis data kuantitatif dengan perhitungan potensi pajak hotel, dan teknik analisis data kualitatif yaitu melalui tahapan reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa perencanaan potensi pajak hotel di BAPENDA Kota Tasikmalaya menggunakan tahapan perencanaan meskipun dalam pelaksanaannya masih terdapat hambatan dalam proses penyusunan perencanaannya dan penggalian potensi pajak hotel tersebut. Saran penelitian ini agar terdapatnya sistem yang bersifat permanen dalam menyimpan data terkait dengan okupansi untuk meninjau potensi pajak hotel tersebut, melakukan inovasi baru terkait sistem informasi BAPENDA Kota Tasikmalaya.
Public perception and usage of the term carbon: Linguistic analysis in an environmental social media corpus
Authors: Gotkova Tomara , Chepurnykh Nikolay 
Published: October 2022

Abstract
The main objective of this study was to examine the specialized environmental vocabulary which is incorporated in ordinary discourse found on the Internet. Specifically, we collected English-language data from two social networks, Twitter and Reddit, with a set of environmental keywords which was compiled using the term candidates extraction technique described in Shvets and Wanner (2020). Furthermore, using data from the initial corpus, we built a smaller sample of texts to serve as a ground for a preliminary linguistic analysis of the environmental term carbon. In environmental discourse, carbon is an umbrella term which has acquired multiple senses when it comes to greenhouse gas emissions. Additionally, this term has settled in ordinary communication (Fletcher & Downing, 2011). By means of a fine-grained manual linguistic analysis applied to the data sample, we identified five semantic patterns in the way the general public conceptualizes carbon in the environmental context.
Diagnostic challenge in an immunocompromised patient
Authors: Ecaterina Stavila , Eugenia Scutaru , Rusu Doina , Botnaru Victor , Alexandru Corlateanu 
Published: October 2022

Abstract
The article presents the case of a 66-year-old non-smoking female patient with HIV-negative status. In 2015, she was diagnosed with chronic lymphocytic leukaemia (CLL) at its early stages, with specific complete blood count changes, peripheral lymphadenopathy and hepatomegaly. No specific treatment was recommended at that time. In July 2018, the diagnosis of non-Hodgkin lymphoma (NHL) IV B stage, with the involvement of all groups of peripheral lymph nodes, was confirmed histologically. No episodes of neutropaenia were recorded. Chemotherapy was initiated. Then, 3 months later, radiological examination revealed a bilateral pulmonary nodular dissemination in the upper lobes, and tuberculous aetiology was confirmed using sputum microscopy and cultural methods (a pansensitive strain). At the end of 8 months of antituberculosis treatment, chest X-ray revealed that apical lung consolidation had diminished, while sputum conversed after 4 months of treatment. After 3 months, the patient presented to the pneumology clinic with haemoptysis. CT revealed bilateral pulmonary consolidation, with cavitation in the left upper lobe and nodules in the surrounding region. Relapse of tuberculosis was excluded microbiologically [this was done using microscopy, cultures and molecular genetic examinations of the sputum and bronchoalveolar lavage (BAL) fluid]. A resistant strain of Staphylococcus aureus (MRSA) was identified, with susceptibility to amikacin and tobramycin. Treatment with amikacin had a positive clinical and imaging effect.
A review of transthyretin cardiac amyloidosis
Authors: Jhawar Nikita , Moreno Juan Carlos Leoni , Chirila Razvan 
Published: October 2022

Abstract
Transthyretin cardiac amyloidosis is a progressive disease known to cause heart failure, conduction anomalies, and arrythmias. Due to poor outcomes and mortality from severe cardiomyopathy, prevalence and incident rates are often underreported. As global longevity is increasing and rates of amyloidosis are also increasing, there is a need to improve diagnostic and therapeutic interventions. Previously, symptom management and transplantation were the mainstay of treatment for heart failure symptoms, but studies using RNAi and siRNA technologies have shifted the paradigm of therapeutic strategy in amyloid cardiomyopathy management. Additionally, early detection and clinical monitoring with numerous imaging and non-imaging techniques are being increasingly investigated. Here, we review the epidemiology, pathophysiology, diagnosis, and management of transthyretin amyloid cardiomyopathy.
اختلاف الشافعية مع المالكية في مسائل إنشاء عقد النكاح في كتاب الاشراف على نكت مسائل الخلاف لعبد الوهاب المالكي -دراسة فقهية مقارنة-
Authors: Hussein Asmaa Hamid , Muhammad Ibrahim Jassim 
Published: October 2022

إنَّ الاختلاف الفقهي بين أئمة المذاهب, هو الذي يُراد به اختلافهم في فهم النصوص وما يُأَوّله كلٌ منهم حسب ما يفهمه من الدليل المتيسر لديه، فالاختلاف بحد ذاته ليس بالهدف المقصود ، لكن ما لا يمكن إنكاره هو أن الخلاف الفقهي يَعد من نتائج الاجتهادية وهو دليل استنتاجات الفقهاء العقلية التي يرومون بها الوصول الى الخيارات الشرعية الصائبة والملائمة، كما إنه دليل على حيوية الفقه الاسلامي وتتميز بخاصية المرونة في فروعه و أصوله مما يعطي القدرة على المواكبة لكل مستجد ومتقيد ، فلاختلاف الفقهي لا يعد أبداً بالأمر المستغرب ما دامَ هناك تباين في مدارك الفقهاء في مواهبهم وقدراتهم ، وإنما ما تركه النتاج الفقهي للسلف الصالح والذي كان من بعض سماته تعدد الآراء في المسألة الواحدة ليعد ثروةً يرجع إليها الخلف متى ما أقتضى الامرُ ، وإن الشريعة الاسلامية أوسعُ من أن يحيطها مذهباً مجتهداً معيناً.
التحليل المكاني لكفاءة التوزيع الجغرافي للمراكز الانتخابية في الجانب الغربي(الأيمن) من مدينة الموصل
Authors: Qassem Al-Taei Sahar Saeed , Hammadi Al Hadidi Nashwan Ali , Aran Hussain Ali 
Published: October 2022

يعد مجال البحث في الانتخابات وظهور الاختلافات المكانية للسلوك الانتخابي وعلاقته بعلم نظم المعلومات الجغرافية وإمكانية اجراء التحليل المكاني للمواقع الانتخابية الحالية من الدراسات المهمة في مجال الجغرافية السياسية. هذا البحث هو محاولة لاقتراح تحديد الموقع الامثل لسهولة وصول الناخبين الى المركز الانتخابي والقيام بالتصويت على اتم وجه، ركزت الدراسة على الجانب الغربي (الايمن) من مدينة الموصل وتم تحديد المسافة المثلى للوصول الى المركز الانتخابي بسقف زمني لا يتجاوز 15دقيقة مشيا على الاقدام. وتم اخذ ومعالجة بيانات المراكز الانتخابية لسنة 2014 وتطبيقها على العديد من الاحياء والطرق والمناطق التي لا تتوفر فيها مراكز انتخابية في الجانب الايمن من مدينة الموصل، والغرض هو لتزويد صناع القرار بالأعداد والمواقع للمراكز المقترحة لسهولة الوصول. أظهرت مخرجات الدراسة ان ما يقارب 30% من السكان الناخبين هم خارج نطاق التغطية بناء على الخطة المقترحة في البحث واستكمالا لما سبق تم العمل على وضع تخطيط مكاني أفضل لمواقع المراكز الانتخابية حيث تم استحداث 30 موقعا إضافيا إلى مجموعة مراكز الانتخاب.
الأمير ظهير الدين الكاكوي ودوره السياسي في ضوء دنانيره المضروبة في أصفهان ( 433-443هـ / 1007-1051م )
Authors: Al-Taie Hatem Fahd Hano 
Published: October 2022

يعد إقليم الجبال من أهم أقاليم المشرق الإسلامي إذ تميز بموقع استراتيجي مهم سكنه الكثير من امراء الدويلات الإسلامية ومنهم امراء آل كاكويه ، ومن مدنه الرئيسة أصفهان موضوع البحث هذا فضلاً عن مدن كثيرة أخرى في هذا الإقليم، وحظيت المسكوكات باهتمام كبير من الحكام والسلاطين لأنها من أهم شارات الملك والسلطان التي حرص كل حاكم على اتخاذها عند توليه السلطة، ولكونها وسيلة إعلامية مهمة لما تمتع به من سعة بالانتشار، وسرعة التداول ، وهي تتصل باقتصاديات الدولة وسياساتها وسائر أوضاعها التجارية والمالية ، كما تُعد وثائق تكشف عن علاقات الدويلات والإمارات والاسر المتعاقبة ، وتتجلى فيها الظواهر السياسية والاقتصادية والاجتماعية والدينية من خلال ما نقش عليها من كتابات ورموز ورسوم والخطوط التي نقشت بها ، فضلا عن اوزانها واقطارها التي جاءت بها . تناول هذا البحث دراسة دنانير الامير ظهير الدين أبي منصور فرامرز بن محمد بن دشمنزار بن كاكويه في أصفهان (398-443هـ / 1007-1051م) وذلك لأن تلك المدينة كانت مركز حكمهم ولدورها الرئيس في سك المسكوكات، فقد تمت دراستها من حيث ما نقىش على وجه وظهر تلك المسكوكات من كتابات وعبارات وتحليلها وربط ما كتب عليها من كتابات بالأحداث التاريخية لسنوات سكها . قسم البحث إلى محورين وخاتمة تضمن المحور الاول اصل بنو كاكويه ، آما المحور الثاني فقد تناول دنانير الامير ظهير الدين أبو منصور فرامرز بن علاء التي سكت في دار سك أصفهان ، كما جاءت الخاتمة لتبين أبرز ما توصل إليه البحث من نتائج.
التكيف الاجتماعي للأسر العائدة من النزوح دراسة أنثروبولوجية ميدانية في مدينة تكريت
Authors: Muhammad Saleh Shabib 
Published: October 2022

هدفت الدراسة الحالية إلى تحديد درجة التكيف الاجتماعي للمهجرين العائدين إلى مجتمعاتهم الأصلية، وتحديد درجة التكيف النفسي والاجتماعي والاقتصادي للمهجرين في منطقة هجرتهم، وفهم الصعوبات التي يوجهها العائدون من الشتات في استيعاب مجتمعاتهم الأصلية. ومقارنة آراء المهجرين وأسرهم حول وضعهم الحالي مع وضعهم بين المغتربين، وكشف حقيقة التفاعل الاجتماعي بين العائلات النازحة على اليسار واليمين. وتحديد الأشكال الأساسية للتفاعل الاجتماعي. وكانت عينة الدراسة 500 تم اختيارهم بشكل عشوائي من محافظة صلاح الدين بمدينة تكريت وتوصل الباحث الي النتائج التالية: 1-أن العديد من العائدين من النزوح ليس لديهم الشعور بالرضا عن عودتهم بسبب الظروف التي يمر بها البلد من تراجع الوضع الأمني وسوء الخدمات .... الخ، 2- النزوح له العديد من الاثار السلبية على الوضع النفسي للإنسان المهاجر قد بدا واضحاً ، 3- إن الآثار السلبية التي خلفتها النزوح على العائدين أكثر من الآثار الايجابية هذا ما ولد أعراض نفسيه حيث كان لها تأثير على تكيفهم في تلك البلدان المهاجرة أليها وكذلك القلق على الأهل لان السلطة في تلك الفترة كانت تستخدم أقسى وسائل التعذيب والقسوة ضد ذوي المهجرين ، 4- سوء المستوى المعاشي للأسر العائدين من المهجر مقارنة مع وضعهم في المهجر مما يؤثر على تكيفهم في المجتمع حيث أن انتشار البطالة وسوء الخدمات وعدم وجود تشريعات قانونية جيدة تنصف العاندين جعلهم يعيشون مستوى معاشي رديء مقارنة بوضعهم المعاشي في المهجر.