bluuebunny/crossref_metadata_2025_split huggingface dataset:
Germline RUNX1 variants in paediatric patients in a French specialised centre
Authors: Liu Cécile , Ballerini Paola , Nguyen Guillaume , Mincheva Zoia , Copin Bruno , Bouslama Boutheina , Leverger Guy , Petit Arnaud , Favier Rémi , Lapillonne Hélène , Boutroux Hélène 
Published: November 2022

AbstractFamilial platelet disorder with associated myeloid malignancy (FPD‐MM; OMIM 601399) is related to germline RUNX1 mutation. The pathogenicity of RUNX1 variants was initially linked to FPD‐MM phenotype, but the discovery of new variants through the expansion of genetic explorations in leukaemia is questioning this assertion. In this study, we add 10 families with germline RUNX1 variant explored at Armand Trousseau Hospital for leukaemia diagnosis or thrombocytopenia, to the 259 described so far. Detailed description of their personal and family history of haematological pathologies allows identifying three phenotypes related to germline RUNX1 variants: thrombocytopenia and/or malignant haematological disease with family history of haematological diseases, thrombocytopenia with no family history of haematological diseases and acute lymphoblastic leukaemia (ALL) with no family history of haematological diseases. In the latter phenotype, ALL characteristics involving RUNX1 suggest the implication of germline variants in the onset of the malignancy.
Weighted inequalities for discrete iterated kernel operators
Authors: Gogatishvili Amiran , Pick Luboš , Ünver Tuğçe 
Published: November 2022

AbstractWe develop a new method that enables us to solve the open problem of characterizing discrete inequalities for kernel operators involving suprema. More precisely, we establish necessary and sufficient conditions under which there exists a positive constant C such that
holds for every sequence of nonnegative numbers where U is a kernel satisfying certain regularity condition, and and are fixed weight sequences. We do the same for the inequality
We characterize these inequalities by conditions of both discrete and continuous nature.
Electrically small asymmetric coplanar strip‐fed metamaterial‐inspired antenna for WLAN and satellite‐based applications
Authors: Pillai Prathibha N. , Pandeeswari Ramasamy 
Published: November 2022

AbstractThis article presents an electrically small asymmetric coplanar strip (ACS)‐fed metamaterial‐inspired antenna for multiband operation. The design employs a simple monopole, a set of rectangular split ring resonator (SRR), an inverted U‐shaped stub, and a rectangular complimentary split ring resonator (CSRR) in the ground plane to realize four operating bands. The antenna operates at 2.46, 5.8, 6.78, and 10.46 GHz with a bandwidth of 270 MHz, 340 MHz,180 MHz, and 1.16 GHz, respectively. The proposed structure has an electrical size of at 2.46 GHz. The experimental results are found to be in close proximity to the simulated ones. The presented electrically small antenna possesses a radian sphere (ka) of 0.68 and achieves an adequate gain of 2.37dBi with requisite radiation characteristics suitable for WLAN and satellite‐based applications.
Wavelet subband discriminator for efficient unsupervised chest X‐ray image restoration
Authors: Song Joonyoung , Ye Jong Chul 
Published: November 2022

AbstractBackgroundChest X‐ray (CXR) images are commonly used to show the internal structure of the human body without invasive intervention. The quality of CXR is an important factor as it affects the accuracy of a clinical diagnosis. Unfortunately, it is difficult to always get good quality CXR scans due to noises and scatters.PurposeRecently, wavelet directional CycleGAN (WavCycleGAN) has shown promising results in image restoration tasks by removing noise and artifacts without sacrificing high‐frequency components of the input image. Unfortunately, WavCycleGAN directly reconstructs wavelet directional images that require a wavelet transform in both the training and test phases, resulting in additional processing steps and unnatural artifacts originating from the wavelet domain image. In addition, WavCycleGAN can only process artifact‐related subbands, so it is difficult to apply WavCycleGAN when different levels of artifacts are present in all subbands. To address this, here we present a novel unsupervised CXR image restoration scheme with similar or even better artifact removal performance than WavCycleGAN in spite of wavelet transform being only applied in the training phase.MethodsWe introduce a novel wavelet subband discriminator which can be combined with CycleGAN or switchable CycleGAN, where wavelet transform is applied only in the training phase for discriminators to match the distribution of wavelet subband components. In our framework, the image restoration network can be still applied in the image domain to prevent unnatural artifacts of the wavelet domain image with the help of the image‐domain cycle‐consistency loss. In addition, using wavelet subband discriminator makes it possible to remove artifacts in all subbands by utilizing frequency‐specific wavelet subband discriminators.ResultsThrough extensive experiments for noise and scatter removal in CXRs, we confirm that our method provides competitive performance compared to existing approaches without additional processing steps in the test phase. Furthermore, we show that our wavelet subband discriminator combined with the switchable CycleGAN can provide the flexibility by generating different levels of artifact removal.ConclusionsThe proposed wavelet subband discriminator can be combined with the existing CycleGAN or switchable CycleGAN structures to construct an efficient unsupervised CXR image reconstruction. The advantage of our wavelet subband discriminator‐based CXR image restoration is that, unlike traditional WavCycleGAN, it does not require any additional processing steps in the testing phase and does not generate unnatural artifacts originating from the wavelet domain image. We believe that our wavelet subband discriminator can be applied to various CXR image applications.
Quadrature transceive wireless coil: Design concept and application for bilateral breast MRI at 1.5 T
Authors: Puchnin Viktor , Jandaliyeva Aigerim , Hurshkainen Anna , Solomakha Georgiy , Nikulin Anton , Petrova Polina , Lavrenteva Anna , Andreychenko Anna , Shchelokova Alena 
Published: November 2022

PurposeDevelopment of a novel quadrature inductively driven transceive wireless coil for breast MRI at 1.5 T.MethodsA quadrature wireless coil (HHMM‐coil) design has been developed as a combination of two linearly polarized coils: a pair of ‘metasolenoid’ coils (MM‐coil) and a pair of Helmholtz‐type coils (HH‐coil). The MM‐coil consisted of an array of split‐loop resonators. The HH‐coil design included two electrically connected flat spirals. All the wireless coils were coupled to a whole‐body birdcage coil. The HHMM‐coil was studied and compared to the linear coils in terms of transmit and SAR efficiencies via numerical simulations. A prototype of HHMM‐coil was built and tested on a 1.5 T scanner in a phantom and healthy volunteer. We also proposed an extended design of the HHMM‐coil and compared its performance to a dedicated breast array.ResultsNumerical simulations of the HHMM‐coil with a female voxel model have shown more than a 2.5‐fold increase in transmit efficiency and a 1.7‐fold enhancement of SAR efficiency compared to the linearly polarized coils. Phantom and in vivo imaging showed good agreement with the numerical simulations. Moreover, the HHMM‐coil provided good image quality, visualizing all areas of interest similar to a multichannel breast array with a 32% reduction in signal‐to‐noise ratio.ConclusionThe proposed quadrature HHMM‐coil allows the ‐field to be significantly better focused in the region‐of‐interest compared to the linearly polarized coils. Thus, the HHMM‐coil provides high‐quality breast imaging on a 1.5 T scanner using a whole‐body birdcage coil for transmit and receive.
Being wheelchair‐bound and being bedridden: Two concept analyses
Authors: Schirghuber Johannes , Schrems Berta 
Published: November 2022

AbstractAimAnalysis of the concepts and development of a conceptual definition of being wheelchair‐bound and being bedridden.DesignConcept analysis.MethodsWalker and Avant´s concept analysis method was used. A thematic analysis guided the determination of the attributes, antecedents and consequences.ResultsBeing wheelchair‐bound and being bedridden are defined as permanent states in which people are bound to an object. Being passively bound to a wheelchair and being bedridden both mean an increasing restriction of the life‐space. Being passive wheelchair‐bound often represents a preliminary stage to being bedridden. Both concepts have six attributes: in need of help, powerlessness, life‐space confinement, mobility limitation, endurance and weakness. They differ in the main feature maintaining an independent sitting position. Physical immobility and physiological instability are antecedents with the following influencing factors: illness, complexity, burden, endogenous/exogenous booster. The consequences are the progression of inactivity and all related physical and psycho‐social problems.
Simultaneous Enhancement of Magnetothermal and Photothermal Responses by Zn, Co Co‐Doped Ferrite Nanoparticles
Authors: Yu Xiang , Yang Tianyu , Liu Ruoshui , Wu Di'an , Tian Daming , Zhou Tianshi , Yan Haitao , He Shuli , Zeng Hao 
Published: November 2022

AbstractReducing nanoparticle (NP) dosage for hyperthermia therapy has remained a great challenge. In this work, efficiencies of alternating current (AC) magnetic field and near‐infrared (NIR) heating are simultaneously enhanced by Zn and Co co‐doping of magnetite NPs. The optimum magnetic anisotropy for maximized loss power under each magnetic field is achieved by tuning the doping concentration. The specific loss power of Zn0.3Co0.08Fe2.62O4@SiO2 NPs reaches 2428 W g−1 under an AC field of 27 kA m−1 at 430 kHz; 12 296 W g−1 under NIR laser irradiation at 808 nm and 2.5 W cm−2; and an unprecedented value of 14 724 W g−1 under dual mode. These values far exceed what has been achieved previously in iron oxide NPs. Ex vivo experiments on sacrificial mice show that while the NP dosage is substantially reduced to that used for magnetic resonance imaging, the surface body temperature of the mice reaches 50 °C after exposure to both AC field and laser irradiation under field parameters and laser intensity below safety limits. This nanoplatform is thus promising for multi‐modal local hyperthermia therapy.
Recent advances in 2D organic−inorganic heterostructures for electronics and optoelectronics
Authors: Khan Jahangir , Ahmad Rana Tariq Mehmood , Tan Junyang , Zhang Rongjie , Khan Usman , Liu Bilu 
Published: November 2022

AbstractTwo‐dimensional (2D) materials show outstanding properties such as dangling bond‐free surfaces, strong in‐plane while weak out‐of‐plane bonding, layer‐dependent electronic structures, and tunable electronic and optoelectronic properties, making them promising for numerous applications. Integrating 2D inorganics with organic materials to make van der Waals heterostructures at the 2D thickness limit has created new platforms for fabricating on‐demand multifunctional devices. To further broaden the limited choices of 2D inorganic‐based heterostructures, a wide range of available 2D organic materials with tunable properties have opened new opportunities for designing large numbers of heterostructures with 2D inorganic materials. This review aims to attract the attention of researchers toward this emerging 2D organic−inorganic field. We first highlight recent progress in organic−inorganic heterostructures and their synthesis and then discuss their potential applications, such as field‐effect transistors, photodetectors, solar cells, and neuromorphic computing devices. In the end, we present a summary of challenges and opportunities in this field.
Multi‐vital on‐skin optoelectronic biosensor for assessing regional tissue hemodynamics
Authors: Xin Ming , Yu Tong , Jiang Yongchang , Tao Ruowen , Li Jiean , Ran Feng , Zhu Tangsong , Huang Jinrong , Zhang Jing , Zhang Jia‐Han , Hu Nan , Wang Wei , Zhang Qiuhong , Liu Zhao , Wang Xinran , Shi Yi , Pan Lijia 
Published: November 2022

AbstractEvaluation of the oxygen‐mediated effects of clinical and daily activities demands an on‐skin device that can track multi‐vital regional tissue hemodynamics simultaneously. For example, peripheral arterial disease (PAD) is the third most prevalent cardiovascular disease, but the means of diagnosing and monitoring this disease are limited because the affected area is usually in the non‐pulsatile area away from the heart. Herein, we report on an ultrathin and ultralight multi‐vital near‐infrared optoelectronic biosensor for the diagnosis and rehabilitation monitoring of regional tissue hemodynamics, which is suitable for mounting on the skin for long‐term measurement. The device can simultaneously detect tissue oxygen saturation, heart rate, arterial blood oxygen, and tissue perfusion and shows potential for various hypoxia monitoring applications. Moreover, the tissue hemodynamics detected by this device showed a highly accordance with the ankle‐brachial index and CT angiography obtained by traditional clinical methods. Therefore, our design was able to accurately diagnose and effectively evaluate PAD patients before and after surgery. The on‐skin optoelectronic biosensor shows potential in biological oxygen‐mediated behavior evaluation, injury‐state monitoring, PAD clinical diagnosis optimization, and after surgery care.
Generation of Bilayer Asymmetry and Membrane Curvature by the Sugar‐Cleaving Enzyme Invertase
Authors: Nowbagh Abhimanyu , Deshwal Akshi , Kadu Mayur , Chaudhuri Abhishek , Maiti Subhabrata , Lipowsky Reinhard , Bhatia Tripta 
Published: November 2022

AbstractThe catalytic action of invertase generates bilayer asymmetry that stabilises membrane curvature. The driving mechanism for the generation of membrane curvature by invertase is investigated using giant unilamellar vesicles (GUVs). The invertase cleaves the sucrose in the exterior compartment, thereby creating a sugar asymmetry across the bilayer membrane that is measured for GUV membranes consisting of the lipid Dioleoylphosphatidylcholine (DOPC). Finally, the advantage of this method to control membrane curvature and to stabilize multi‐sphere morphologies is demonstrated. The GUV system in the presence of invertase is beneficial as a tool to generate multiple on‐demand compartments with more extended stability after the enzymatic activity has established the asymmetry.
Farm animal careers and perception of ‘fit’ in undergraduate veterinary students: A mixed methods study
Authors: Payne Emily , Morton Emily , Lally Christopher , Remnant John 
Published: November 2022

AbstractBackgroundRecruitment and retention of farm veterinarians have been the focus of recent research. Previous work suggests that a feeling of ‘fit’ is important for students to consider a farm career. The aim of this study was to identify whether students feel that they ‘fit’ in farm practice and reasons for their answer.MethodsAn online survey was distributed to students at all British and Irish veterinary schools. A mixed methods approach was considered, with thematic analysis on free text answers and regression analysis on demographic variables.ResultsThematic analysis identified six themes: career opportunities, nature of farm veterinary work, relationships and interactions, individual experiences, expectations and perceptions, and no perceived barriers. Females, marginalised ethnic groups and those from an urban/suburban background were all identified as having significantly (p < 0.05) less agreement with the statement ‘I feel able to pursue a career in farm practice’.LimitationsSurvey limitations include those with a clear bias being likely to respond. However, alignment of the qualitative and quantitative results increased confidence in the findings of this mixed methods approach.ConclusionThis study confirms that biases that exist within wider society do have an influence on veterinary undergraduates' intentions to pursue a farm animal career. This is vital to consider both at a university level and when considering students' experiences on placements. Urgent action is required to improve inclusivity in the farm animal veterinary sector.
Assessing the variation of river channel reach inflows on transmission losses
Authors: Mujere Never , Masocha Mhosisi , Makurira Hodson , Mazvimavi Dominic 
Published: November 2022

AbstractArid and semi‐arid regions are characterized by limited water availability throughout the year and highly variable streamflows. River channel transmission losses add another uncertainty to the complex flow regimes. However, the contribution of different factors influencing to transmission losses is poorly understood. In this work we determined whether variations in river channel transmission losses along five reaches of varying lengths could be related to reach inflows in Runde River catchment in Zimbabwe. We directly estimated transmission losses as the difference between reach inflow and outflow discharges. Using simple bivariate regression equations, channel transmission losses were modeled as response variables while reach inflows were the predictor variables. Our results indicate statistically significant positive relationships (p = .000, R2 > 0.05) between inflows and transmission losses for all minor, moderate, and major flow events. This simple approach can be applied in similar settings to understand the variations in transmission losses.
A Digital Application for Strategic Development of Health Tourism Destinations
Authors: Mahroo Atieh , Spoladore Daniele , Ferrandi Paolo , Lovato Ilenia 
Published: November 2022

AbstractThis work describes the challenges, techniques, and methodologies to develop a digital tool that aims to improve framework conditions and tools for better utilization of Alpine natural resources in health tourism. Starting from the literature analysis and an online survey, the system implemented a comprehensive knowledge base adopted for an ontology-based Decision Support System leveraging on identified Key Performance Indicators (KPIs). Relying on this knowledge, the digital tool provides a list of tailored and customized recommendations for each destination within the Alpine area. This result helps the stakeholders capitalize on the nature-based health tourism potentials of their region in relation to the existence of the natural resources and different target users’ health conditions. This strategic digital tool is developed as a web-based application for destinations’ policy-makers and managers to fill the online survey and receive customized suggestions, recommendations, and insights on how to further exploit their natural resources in order to enhance nature-based health tourism.
Stability of sample extracts of vitamin D3 metabolites after chemical derivatization for LC–MS/MS analysis
Authors: Alexandridou Anastasia , Volmer Dietrich A. 
Published: November 2022

AbstractLiquid chromatography/tandem mass spectrometry (LC–MS/MS) is widely used to determine vitamin D3 metabolites in biological samples. The ionization efficiencies of these metabolites, however, are poor under electrospray ionization conditions. Moreover, the chromatographic separation of multiple vitamin D metabolites and their epimers can be challenging. For these reasons, chemical derivatization reagents are often used to improve sensitivity and selectivity of analysis. While the derivatization schemes have been proven to be very effective, one missing aspect is the investigation of the stability of the chemical derivatization products in stored sample extracts. In this study, we investigated the long-term stability of several vitamin D3 metabolites after 1 and 3 months of storage at − 20 °C. Five vitamin D3 metabolites were examined after derivatization with seven different derivatization reagents. Generally, Amplifex products were the most stable in the long term in our study with 11–20% degraded after 1 month of storage and 14–35% after 3 months. The stabilities for some of the metabolites′ 4-[2-(6,7-dimethoxy-4-methyl-3-oxo-3,4-dihydroquinoxalyl)ethyl]-1,2,4-triazoline-3,5-dione (DMEQ-TAD), 2-fluoro-1-methylpyridinium p-toluenesulfonate (FMP-TS), isonicotinoyl chloride (INC) and 4-phenyl-1,2,4-triazoline-3,5-dione acetylated (PTAD-Ac) products were also acceptable after 1 month of storage. Other derivatized metabolites, however, degraded extensively already after 1 month of storage, such as 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD) (54–72% degradation) and 2-nitrosopyridine (PyrNO) (32–100% degradation). Importantly, for every metabolite, there was an optimum derivatization reagent that met the criteria of stability proposed by international regulatory bodies after 1 month of storage. Some derivatives were stable for even up to 3 months of storage, with degradation of less than 15%.
Graphical abstract
Different approaches to test orientation of self in space: comparison of a 2D pen-and-paper test and a 3D real-world pointing task
Authors: Gerb J. , Brandt T. , Dieterich M. 
Published: November 2022

AbstractSpatial orientation is based on a complex cortical network with input from multiple sensory systems. It is affected by training, sex and age as well as cultural and psychological factors, resulting in different individual skill levels in healthy subjects. Various neurological disorders can lead to different patterns or specific deficits of spatial orientation and navigation. Accordingly, numerous tests have been proposed to assess these abilities. Here, we compare the results of (1) a validated questionnaire-based self-estimate of orientation/navigation ability (Santa Barbara Sense of Direction Scale, SBSODS) and (2) a validated pen-and-paper two-dimensional perspective test (Perspective Taking Spatial Orientation Test, SOT) with (3) a newly developed test of finger-arm pointing performance in a 3D real-world (3D-RWPT) paradigm using a recently established pointing device. A heterogeneous group of 121 participants (mean age 56.5 ± 17.7 years, 52 females), including 16 healthy volunteers and 105 patients with different vestibular, ocular motor and degenerative brain disorders, was included in this study. A high correlation was found between 2D perspective task and 3D pointing along the horizontal (azimuth) but not along the vertical (polar) plane. Self-estimated navigation ability (SBSODS) could not reliably predict actual performance in either 2D- or 3D-tests. Clinical assessment of spatial orientation and memory should therefore include measurements of actual performance, based on a 2D pen-and-paper test or a 3D pointing task, rather than memory-based questionnaires, since solely relying on the patient’s history of self-estimated navigation ability results in misjudgments. The 3D finger-arm pointing test (3D-RWPT) reveals additional information on vertical (polar) spatial performance which goes undetected in conventional 2D pen-and-paper tests. Diseases or age-specific changes of spatial orientation in the vertical plane should not be clinically neglected. The major aim of this pilot study was to compare the practicability and capability of the three tests but not yet to prove their use for differential diagnosis. The next step will be to establish a suitable clinical bedside test for spatial memory and orientation.