bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Analysis of Stochastic Nonlinear Dynamical Systems. Part 2: Influence of Uncertainties and Noise on Basins/Attractors Topology and Integrity
Authors: Benedetti Kaio C. B. , Gonçalves Paulo Batista , Lenci Stefano , Rega Giuseppe 
Published: July 2022

Abstract
This paper explores the influence of uncertainties and noise on the global dynamics of nonlinear systems, with emphasis on the basins and attractors’ topology and on the dynamic integrity of coexisting solutions. For this, the adaptive phase-space discretization strategy proposed in Part I [1] is employed. Two well-known archetypal oscillators found in engineering applications, the Helmholtz and Duffing oscillators under harmonic or parametric excitation with uncertain parameters or added load noise, are studied. The results demonstrate the adaptive capability of the proposed method, increasing the resolution without increasing the computational cost. Mean basins of attraction and attractors’ distributions are obtained. The time-dependency of stochastic responses is demonstrated, with long-transients influencing the short-term behavior. Finally, the effect of uncertainties and noise on the basins areas, attractors distributions and basin boundaries is discussed, which can be used to evaluate the dynamic integrity of the competing basins.
Variation in tolerance to high temperature and water stress in weedy Bidens pilosa seeds from Yunnan, SW China
Authors: Wen Bin , An Xuejiao , Chen Ligang , Yin Xuejing , Mi Limei 
Published: July 2022

Abstract
Using Bidens pilosa seeds from three provenances in Yunnan, this study comprised an investigation of changes in seed viability and germination under high temperature and water stress. It was found that B. pilosa seeds had a wide temperature range for germination, as all seeds germinated in the incubation temperature range of 10–30°C, under no more than a 6-h daily thermoperiod at 40°C and moisture regime no less than − 0.6 MPa, regardless of the seed provenance. The seeds showed no substantial viability loss after no longer than 8 d of continuous heating at 40°C or 30 min heating at no higher than 50°C. However, obvious intra-specific variation was found among seeds from these provenances when further stress was applied. Seeds from Xishuangbanan (N21°41′) always exhibited the most high-temperature tolerance, whereas those from Diqin (N27°11′) had the least and those from Chuxiong (N25°10′) had intermediate tolerance, regardless of whether this was assayed based on the ceiling temperature for germination, the maximal daily thermoperiod, the longest continuous heating duration at 40°C, or the endurable maximum temperature for 30 min of heating, indicating the adaption of invasive plants to invaded habitats. This study supported our hypothesis that B. pilosa seeds from different provenances have intra-specific divergence in germination traits and high-temperature tolerance to adapt to local conditions. It was concluded that high-temperature tolerance is an important seed trait that affects plant invasion success in open habitats in Xishuangbanna.
Sex-specific effect of obesity on epiblepharon in different age groups: a case-control study
Authors: Wang Jin-Jhe , Lai Chien-Hsiung , Kuo Ting-Yu , Lin Meng-Hung , Yang Yao-Hsu , Chen Chau-Yin 
Published: July 2022

Abstract
Background: Obesity has been regarded as a risk factor for epiblepharon. This study aims to investigate the age- and sex-specific relationship between epiblepharon and obesity in children.Methods: A retrospective case-control study was conducted using Chang Gung Research Database. Children ≤ 18 years of age with epiblepharon were identified from 1 January 2009 to 31 December 2019. Children were classified into four groups: underweight, normal, overweight and obese groups.Results: A total of 513 patients and 1026 controls (57.7% of males) aged 1 to 18 matched by sex and age were included in the analysis. The median body mass index (BMI) of children with epiblepharon was significantly higher than that of children without epiblepharon (p < 0.001). In the subgroup analysis, among boys aged 4 to 9 years, the BMI in boys with epiblepharon was significantly higher than that in boys without epiblepharon (p < 0.05) and the risk of epiblepahron in overweight and obese boys was significantly higher than in non-overweight boys (OR = 1.74, 95% CI = 1.07-2.82; OR = 3.06, 95% CI = 1.56-6.03). On the other hand, among girls aged 13 to 18 years, the BMI in adolescent girls with epiblepharon was significantly higher than that in the control group (p < 0.05) and overweight and obese girls had statistically higher risk of persistent epiblepharon than non-overweight girls (OR =3.70, 95% CI = 1.38-9.97).Conclusions: The association between obesity and epiblepharon varies in strength according to age in a sex-specific manner.
Systematic Review of Health Related-Quality of Life in Adults with Osteogenesis Imperfecta
Authors: Donald Darran Mc , Donnell Tara Mc , Martin-Grace Julie , Manus Gerry Mc , Crowley Rachel K 
Published: July 2022

Abstract
BackgroundOsteogenesis imperfecta (OI) is a rare, connective tissue disorder characterised by bone fragility, resulting in recurrent fractures and skeletal deformities. Extra-skeletal manifestations include dentinogenesis imperfecta, hearing abnormalities and restrictive lung disease. These co-morbidities combined with recurrent fractures can exert a significant impact on health-related quality of life (HR-QOL). It is important to have a clear understanding of HR-QOL throughout adulthood as some OI specific complications increase with age.MethodsPubMed, EMBASE and CENTRAL databases were searched in February 2022 to identify studies reporting quantitative assessments of HR-QOL in adults with OI. The primary endpoint was to determine the impact of a diagnosis of OI on an adult’s HR-QOL. Secondary endpoints were (i) to examine how frequently various HR-QOL assessment tools were used (ii) identify differences in HR-QOL between OI types and (iii) to investigate the determinants of HR-QOL in adults with OI. Search results were exported to Endnote where two reviewers independently conducted title/abstract and full text reviews. Data from accepted studies were extracted into Microsoft Excel. A narrative synthesis was then undertaken. ResultsThe review identified 17 studies with a total of 1,648 adults. The Short Form-36 (SF-36) was the most widely reported HR-QOL assessment tool, used in nine studies. Physical HR-QOL was reduced in adults with OI. Physical component scores (PCS) or individual physical domains of the SF-36 were lower in eight of nine studies. Mental component scores (MCS) were preserved in all six studies, however individual mental health domains of the SF-36 were reduced in some studies. The prevalence of anxiety/ depression was relatively low in adults with OI. Those with type 3 OI, had lower physical and respiratory HR-QOL but preserved mental HR-QOL compared with type 1. The prevalence of fatigue and pain were higher in adults with OI. Age and cardio-pulmonary co-morbidities were associated with lower HR-QOL. ConclusionOI has an extensive and wide ranging impact on adult HR- QOL. Physical and respiratory HR-QOL were lower, while the prevalence of pain and fatigue were higher than reference populations. Mental HR-QOL was relatively preserved. Age and cardio-pulmonary co-morbidities were associated with lower HR-QOL.
Beneficial effects of physical activity in Rheumatoid Arthritis patients: focus on active biomolecules
Authors: Restuccia Roberto , Ficarra Giovanni , Perani Fulvio , Bagnato Gianluca , Bitto Alessandra , Magaudda Ludovico , Trimarchi Fabio 
Published: July 2022

Abstract
Physical activity (PA) has a fundamental role in subjects with rheumatoid arthritis (RA), in terms of motility, joint function, muscle wasting, BMI (body mass index), cardiovascular fitness (CRF), mental health, but also changes in bioactive molecules that might influence the disease activity and patient’s wellbeing. A systematic search of Pubmed and Google Scholar library was performed for clinical trials, randomized-controlled trials, and pilot studies published in the last 15 years. Studies using as adjunctive therapy aerobic exercise, high-intensity interval training (HIIT), and moderate training as yoga were included. The available papers shown that exercise programs improve joint’s mobility and flexibility and the overall health status, without differences regarding age, gender or disease activity. All these findings are supported by the modulatory role of exercise-induced cytokines as interleukin-6 (IL-6) and irisin, together with a reduction of inflammatory markers.
Utility of eConsults for COVID-19 Vaccine-Related Concerns in Ontario: A Cross-Sectional Review
Authors: Walter Graham , Jeimy Samira , Liddy Clare , Guglani Sheena , Ellis Anne K , Blair Amy , Kobayaa Hazar , Chad Zave , Keely Erin 
Published: July 2022

Abstract
Background
The Champlain BASE™ and Ontario eConsult services are virtual platforms that serve to facilitate contact between primary care providers and specialists across Ontario, relaying patient-specific questions to relevant specialists via a secure web-based platform. Despite ample evidence regarding the general effectiveness of these platforms, their utility as it pertains to clinical concerns regarding COVID-19 vaccines has not yet been explored.
Methods
We performed a cross-sectional review of COVID-19 vaccine related eConsults on Ontario patients completed by five allergy specialists between February and October of 2021. 4318 COVID-19 vaccine-related eConsults were completed in total during this time; with 1857 completed by the five allergists participating in this analysis. Question types/content were categorized using a taxonomy developed through consensus on a weighted monthly sample of 499 total cases. Data regarding whether external resources were required to answer each eConsult, impact on primary care provider referral decisions, and allergy consultant response times were collected. A 2-question survey was completed by primary care providers following eConsultation and results were collected.
Results
41.08% of eConsults received involved safety concerns regarding COVID-19 vaccine administration in the setting of prior allergic disease and another 36.1% involved a potential reaction the first dose of a COVID-19 vaccine. 72.1% of eConsults were answered by specialist without needing external resources, and only 9.8% of all eConsults received resulted in a recommendation for formal in-person referral to Clinical Immunology & Allergy specialist or another subspecialty. Average time to complete eConsult was 16.4 minutes, and 79.7% of PCP eConsult queries which would have traditionally resulted in formal consultation were resolved based on advice provided in the eConsult without need for in-person assessment.
Conclusions
Our review demonstrates the utility of the eConsult service as it pertains to COVID-19 vaccine-related concerns. The eConsult platform proved an effective tool in diverting the need for in person assessment by an Allergist or other medical specialty. This is significant given the large volume of eConsults completed by Allergists, and demonstrates the impact of an effective electronic delivery of care model during a time of strained resources and public health efforts directed at mass vaccination.
Predictors of long-term durable response in de novo HER2 positive metastatic breast cancer and the real world treatment experience at two institutions
Authors: Smith Claire Elizabeth Powers , Marcom Paul K. , Mitri Zahi , Ko Naomi 
Published: July 2022

Abstract
Purpose HER2-directed therapies enable some patients with de novo HER2+ metastatic breast cancer (MBC) to achieve long-term, durable responses (DR). Expert opinion dictates indefinite HER2-directed therapies for patients who achieve DRs, but real-world examples of this practice are lacking in the literature. Patient-factors that predict DR continue to be elucidated. MethodsThis is a retrospective study of patients with de novo HER2+ MBC. DR is defined as absence of progression/death at any point after diagnosis. Controls are patients with evidence of progression/death. Age, ER/PR status, sites of metastasis, surgical resection of primary tumor and initial treatment were analyzed. Results96 patients with de novo HER2+ MBC, 28 with DR and 68 with progression, were identified. 75% of patients with DR had a single metastatic site, compared with 47% of patients with progression (OR 3.7, p=0.01). 64% of patients with DR received a regimen containing trastuzumab, pertuzumab, and a taxane, while 28% of patients who progressed did (OR 4.5, p<0.001). 57% of patients with DR underwent surgical removal of breast primary, compared with 24% of patients who progressed (OR 4.3, p=0.002.) Among patients with DR, nine patients have been receiving trastuzumab for over ten years with no evidence of disease.ConclusionNearly a third of patients with de novo HER2+ MBC achieved DR. Factors that correlate with DR include single metastatic site, initial trastuzumab, pertuzumab and taxane therapy, and surgical resection of primary tumor. Among patients with DR, indefinite trastuzumab administration is the norm.
Factors Related to Early Readmissions After Acute Heart Failure: a Nested Case- Control Study
Authors: Garcia-Gutierrez Susana , Villanueva Ane , Lafuente Iratxe , Rodriguez Ibon , Lozano Ainara , Murga Nekane , Orus Josefina , Camacho Emilia Rosa , Quintana Jose María , Quiros Raul 
Published: July 2022

Abstract
AIMS: To describe the main characteristics of patients who were readmitted to hospital within 1 month after an index episode for acute decompensated heart failure (ADHF).METHODS AND RESULTS: This is a nested case-control study in the ReIC cohort, cases being consecutive patients readmitted after hospitalization for an episode of ADHF and matched controls selected from those who were not readmitted. We collected clinical data and also patient-reported outcome measures, including dyspnea, Minnesota Living with Heart Failure Questionnaire (MLHFQ), Tilburg Frailty Indicator (TFI) and Hospital Anxiety and Depression Scale scores, as well as symptoms during a transition period of 1 month after discharge. We created a multivariable conditional logistic regression model.Despite cases consulted more than controls, there were no statistically significant differences in changes in treatment during this first month. Patients with chronic decompensated heart failure were 2.25 [1.25, 4.05] more likely to be readmitted than de novo patients. Previous diagnosis of arrhythmia and time since diagnosis ≥3 years, worsening in dyspnea, and changes in MLWHF and TFI scores were significant in the final model.CONCLUSION: We present a model with explanatory variables for readmission in the short term for ADHF. Our study shows that in addition to variables classically related to readmission, there are others related to the presence of residual congestion, quality of life and frailty that are determining factors for readmission for heart failure in the first month after discharge.ClinicalTrials.gov Identifier: NCT03300791. First registration: 03/10/2017
A miniaturized microstrip antenna with tunable double band-notched characteristics for UWB applications
Authors: Chao Zhang , Zitong Zhao , Jie Yu , Pei Xiao , Zhu Liu , Gaosheng Li 
Published: July 2022

Abstract
In this paper, a miniaturized ultra-wideband( UWB) microstrip antenna with independent tunable double band-notched characteristics is presented, which consists of the semicircle ring-like radiating patch with an elliptical-shaped slot and double split ring resonators(SRRs) on the top surface of the substrate and defected ground structure(DGS) on the bottom surface of substrate. The operating frequencies have range from 1.3GHz to 11.6GHz(S11<-10dB). The double band-notched characteristics have been achieved by etching elliptical-shaped slot at the radiating patch and placing double C-shaped SRRs at the both side of the microstrip feed line. By loading varactor diodes at the gap of the elliptical-shaped slot and the double C-shaped SRRs and changing the reverse-bias control voltage of the varactor diodes, the notch frequency can be electronically tuned efficiently. The experimental results, which are agree well with the simulated results, demonstrate that the proposed antenna have created the notched frequency band shift from 2.47GHz to 4.19GHz(1.72GHz) and 4.32 GHz to 5.96GHz(1.64GHz) when the reverse bias voltage vary from 0V to -30V corresponding to the junction capacitance of varactor diode has decreased from 2.67pF to 0.63pF, which imply that the proposed antenna with band-notched characteristics has the capability to suppress the narrow interference signals which cover the wireless local area network(WLAN) and world interoperability for microwave access(WiMAX) band. Furthermore, the proposed antenna structure only has the electrical size of 0.26λ*0.19λ at 1.3GHz. Compare to the related reported antennas, the proposed antenna has achieved compact size, tunable dual band-notched characteristics and good band-notched performance simultaneously to the best of our knowledge. It is believed that the proposed antenna will have a very valuable prospect in the fields of wireless body area network (WBAN), UWB communication, Internet of Things(IoT), etc.
Influence of Energy Loss Function to the Monte Carlo Simulated Electron Backscattering Coefficient
Authors: Chen Haotian , Zou Yanbo , Mao Shifeng , Khan M. S.S. , Tokesi K. , Ding Z.J. 
Published: July 2022

Abstract
We present an improved calculation of the electron backscattering coefficients (BSCs) for beryllium (Be), molybdenum (Mo) and tungsten (W) at electron energies of 0.1-100 keV based on an up-to-date Monte Carlo simulation method with different input of energy loss function (ELF) data. The electron inelastic cross-section is derived from the relativistic dielectric functional formalism, where the full Penn’s algorithm is applied for the extension of the ELF from the optical limit of q→0 into the ( q,ω)-plane. We have found that the accuracy of energy loss function may affect largely the calculated BSC. We also show that this has in close relationship with the f- and ps-sum rules.
Effect of mixotrophy on lipid content and fatty acids methyl esters profile by Chlorella zofingiensis grown in media containing sugar cane molasses
Authors: Vitali Lorenzo , Lolli Veronica , Sansone Francesco , Concas Alessandro , Lutzu Giovanni Antonio 
Published: July 2022

Abstract
The effect of mixotrophy on lipid content and fatty acids methyl ester (FAME) profile by Chlorella zofingiensis is investigated in this work. For this purpose, growth media containing specific concentrations of sugar cane molasses, are used to sustain microalgae growth. Lipids have been extracted from microalgae and then characterized. Specifically, all FAMEs have been quantitatively and qualitatively analyzed in order to improve biodiesel properties. Results showed that using specific concentrations of molasses the total lipid content increased up to 20% compared to the control. FAME profile revealed a 97% composition in C16-C18 where unsaturated fatty acids reached a high portion (77%) when using 2 g L -1 molasses. Main characteristics of biodiesel obtainable from the algal lipids are also evaluated. Based on the biomass and lipid productivity achieved during the experiments as well as on the compliance of the corresponding biodiesel characteristics with its international standards, it can be stated that molasses waste is a viable option as a cheap medium for the cultivation of Chlorella zofingiensis .
A review on clinical use of CAD/CAM and 3D printed dentures in dental practices
Authors: Alhallak Khaled , Nankali Ali , Hagi-Pavli Eleni 
Published: July 2022

Abstract
The aim of this article was to review the current clinical application of Computer-aided design/computer-aided manufacturing (CAD/CAM) and three dimensional (3D) printed dentures in dental clinics. Methods: A systematic approach for searching PubMed, Embase, Scopus, and Web of Science databases. The search was performed using a variety of keywords including clinical use AND 3D printed removable dentures OR clinical use AND CAD/CAM removable dentures OR clinical use AND digital removable dentures. Selection criteria included articles written in English and reporting information on clinical applications of digital dentures between 2010 to January 2022. Results: The findings outlined the main clinical advantages of digital dentures such as saving working time, satisfying clinical results and securing patients records, and also requirement of additional visits to secure esthetic patient satisfaction, good retention and ideal vertical dimension. Many studies recommended performing clinical try-in in regards to provide better results. It was also established that 3D printers are less expensive than milling centers and therefore can be afforded by individual dental professionals.Conclusion: Digital dentures are a promising treatment and offer superior possibilities in the field of prosthodontics especially in lower-income areas where skilled technicians are scarce. However, there are some limitations in their applications.
Development and Validation of an Oxidative Stress-Related Prognostic Signature Associated with Immune Infiltration in Osteosarcoma
Authors: Xie Bin , Tan Shiyong , Li Chao , Liang Junyang 
Published: July 2022

Abstract
Background: Osteosarcoma (OS) is one of the most prevalent malignancies and oxidative stress is closely associated with osteosarcoma. A number of measures have been taken to make the prognosis of osteosarcoma better. Nevertheless, the situation is still critical. We therefore aimed to establish a prognostic oxidative stress-related gene signature and to study its relevance to immune infiltration in OS. Materials and Methods: Supported by The Cancer Genome Atlas (TCGA) database, we studied gene expression and clinical information of OS patients. Prognostic oxidative stress-related genes were screened and then a prognostic nomogram model was developed and assessed. All patients were classified into a high risk group and a low risk group. Single-sample gene set enrichment analysis (ssGSEA) was applied to analyze the level of immune infiltration in two groups.Results: Five genes most associated with the prognosis of OS patients were identified as independent predictors, namely CAT, MAPK1, G6PD, MAP3K5, and CCL2. Based on the signature, patients with higher risk scores having poorer prognosis. Nomogram performed well and reliably predicted 3-year (AUC = 0.83) and 5-year (AUC = 0.86) survival in OS patients. The high-risk group had higher tumor purity and lower levels of immune cell and immune-related functional infiltration compared to the low-risk group (P < 0.05).Conclusion: The new five oxidative stress-related genes signature could effectively predict the prognosis of OS patients and were expected to be potential prognostic biomarkers. And it provided new ideas for understanding the interactions between cellular oxidative stress mechanisms and tumor, and provided a new basis for disease management.