bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peroxiredoxin 2 is required for the redox mediated adaptation to exercise
Authors: Xia Qin , Casas-Martinez José Carlos , Zarzuela Eduardo , Muñoz Javier , Miranda-Vizuete Antonio , Goljanek-Whysall Katarzyna , McDonagh Brian 
Published: December 2022

AbstractExercise generates a site-specific increase in Reactive Oxygen Species (ROS) within muscle required for a beneficial adaptive response by activation of specific signalling pathways. Here, we demonstrate that Peroxiredoxin 2 (Prdx2), an abundant cytoplasmic 2-Cys peroxiredoxin, is required for the adaptive beneficial hormesis response to H2O2. A short bolus addition of H2O2increases mitochondrial capacity and improves myogenesis of cultured myoblasts, this beneficial adaptive response was suppressed in myoblasts with decreased expression of cytoplasmic Prdxs. A swimming exercise protocol inC. elegansincreased mitochondrial content, fitness, survival and longevity in wild type (N2) worms. In contrast,prdx-2mutant worms had decreased fitness, disrupted mitochondria, reduced survival and lifespan following exercise. Global proteomics following exercise identified distinct changes in the proteome of N2 andprdx-2mutants. Furthermore, a redox proteomic approach to quantify reversible oxidation of individual Cysteine residues revealed a relatively more oxidised redox state following exercise in theprdx-2mutants. Our results demonstrate that conserved cytoplasmic 2-Cys Peroxiredoxins are required for the beneficial adaptive response to a physiological stress.
Enhancing flow characteristic and system performance in micropump with heart valve mechanical behavior
Authors: Lai Hsin-Yi , Kang Jing-Hao 
Published: December 2022

PurposeThis study aims to solve the problems of low flow rate and low efficiency of micropumps in high-frequency applications. This micropump system was proposed to meet the requirements of 1–5 ml/min for microthrusters or drug delivery devices.Design/methodology/approachIn this paper, a comprehensive analysis indicator and numerical procedure were disclosed and used to demonstrate the fluid dynamic characteristics and performance of a micropump. Accordingly, the reliability of the two-way coupling calculation was ensured through mutual verification of the real structure and the numerical system.FindingsThe research results indicate that the Polydimethylsiloxane (PDMS) microchannel can realize the contraction and expansion mechanism, allowing the fluid to generate different levels of pressure gradient during the working stroke and also enhancing the characteristics of energy consumption and storage of the flow field.Originality/valueThe pressure gradient between the fluid and PDMS microchannel can facilitate the improvement of the fluid backflow in a micropump. Therefore, in terms of performance improvement, the PDMS micropump increased the maximum backflow and optimum efficiency by approximately 50 and 90%, respectively.
Scarabaeus Sacer: an iconic green brand advocating sustainability in the era of digital economy and connectivity
Authors: Ghalwash Seham , Ismail Ayman , Maurya Mohit 
Published: December 2022

Learning outcomes
Learning outcomes can only be achieved through using case-based pedagogy. Instructors must encourage students to dive deeply into the case dilemma, so they are able to engage with the case objectives and questions, applying the appropriate theory. By doing so, students can provide solutions based on five core objectives. These are the objectives that students should learn after completing the case discussion: ■ Critique the marketing activities for implications of global branding. ■ Understand the turnaround strategies in the context of the digital economy and COVID-19 crisis to build a global brand and drive B2C customers from awareness and advocacy. ■ Suggest a map of traditional and digital marketing strategies to enhance the company’s efficiency and effectiveness. ■ Discuss the three main sources of influence marketers can implement to drive customers from awareness to advocacy across the customers’ path. ■ Discuss the application of the UN 17 SDGs practices in today’s fashion industry.

Case overview/synopsis
In 2018, Ali El Nawawi and Mai Kassem decided to start up the Scarabaeus Sacer brand to take their passion for social and human development and create ethical fashion streetwear. Scarabaeus Sacer was an Egyptian brand that sold 100% organic Egyptian cotton fashionable streetwear, and the core mission of the fledgling company was “promoting Egyptian organic cotton textiles with a premium quality globally” (Al Nawawi, 2021). While Scarabaeus was mainly guided by the well-being, sustainability, and mental health goals of the UN Sustainable Development Goals (SDGs) numbers 3, 8, 11 and 12 (good health and well-being; decent work and economic growth; sustainable cities and communities; and responsible consumption and production), their position as an advocacy brand was only beginning to be understood by their customers in Egypt. With the rapid increase of e-commerce during the COVID-19 crisis and their previous international experience, the co-founders wanted to achieve their mission of building a global brand that promotes Egyptian organic cotton and sustainability while offering unique designs of fashionable streetwear. To achieve this mission, the co-founders El Nawawi and Kassem faced major decisions related to marketing strategies at the beginning of 2020. These included how to build global brand awareness and brand advocacy for well-being, sustainability and mental health with a special focus on penetrating new markets (namely, Europe and the USA) to stock their products on e-commerce platforms and advocating their cause and increase their sales.

Complexity academic level
This case is suitable for graduate-level marketing courses in which it allows students to engage with classical marketing strategies, digital marketing, global branding, communication, media and sales within a management framework.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 3: Entrepreneurship.
A network analysis of tourist activity
Authors: Chen Yong 
Published: December 2022

Purpose
This study aims to model tourist activities in a network and explore the properties of the network. Such network enables the author to explain and quantify how tourist activities are connected in determining tourist consumption as well as the organization of destination supply.

Design/methodology/approach
The author developed a network formation mechanism to create edges between nodes based on the joint probability of a pair of activities undertaken by tourists at a destination. By adjusting network sparsity, the author created an ensemble of four topologically similar networks for empirical testing. The author used tourist activity data of Hong Kong inbound tourists to test the network model.

Findings
The author found a robust hub–periphery topological structure of the tourist activity network. In addition, the network is featured by high clustering, short diameter and positive correlations between four node centralities, namely, degree, closeness, betweenness and eigenvector centralities. The author also generated the k-cores of the networks to further unravel the structure of hub nodes. The author found that the k-cores are dominated by tourist activities related to shopping or sightseeing, suggesting the high complementarity of these activities.

Research limitations/implications
This study provides a different lens through which tourist consumption can be understood from a macroscopic angle by examining network topology and from a microscopic angle by examining node centralities.

Originality/value
To the best of the author’s knowledge, this is the first study attempting to model tourist activity and consumption in a network and explore the properties of the network. Not only has this study provided a new real-world network for network research, but it has also suggested an innovative modeling approach for tourist behavior research.
Priorities in integrating primary and secondary care: a multimethod study of GPs
Authors: Dunlea Shane , McCombe Geoff , Broughan John , Carroll Áine , Fawsitt Ronan , Gallagher Joe , Melin Kyle , Cullen Walter 
Published: December 2022

PurposeThroughout the world, healthcare policy has committed to delivering integrated models of care. The interface between primary–secondary care has been identified as a particularly challenging area in this regard. To that end, this study aimed to examine the issue of integrated care from general practitioners’ (GPs) perspectives in Ireland.Design/methodology/approachThis multimethod study involved a cross-sectional survey and semi-structured interviews with GPs in the Ireland East region. A total of 1,274 GPs were identified from publicly available data as practising in the region, of whom the study team were able to identify 430 GPs with email addresses. An email invite was sent to 430 potential participants asking them to complete a 34-item online questionnaire and, for those who were willing, an in-depth interview was conducted with a member of the study team.FindingsIn total, 116 GPs completed the survey. Most GPs felt that enhancing integration between primary and secondary care in Ireland was a priority (n = 109, 93.9%). Five themes concerning the state of integrated care and initiatives to improve matters were identified from semi-structured interviews with 12 GPs.Originality/valueThe uniqueness of this study is that it uses a multimethod approach to provide insight into current GP views on the state of integrated care in Ireland, as well as their perspectives on how to improve integration within the Irish healthcare system.
Narrative encounters of pedagogic partnership, and the development of collegial capital in higher education
Authors: Mariaye Hyleen , Price Mark , Ramasawmy Shalini Jagambal , Melvin Jane , Mohabeer Tejwant 
Published: December 2022

PurposeThe study explores the relational encounters of five higher education tutors and programme leaders, working in collaboration across contrasting institutions: one, a modern, civic university in the Global North, and the other, a parastatal institution in the Global South. The purpose of the study is to deepen the understanding of evolving collegiality within a transnational partnership, stimulated by the COVID-19 pandemic related shift to online teaching and learning.Design/methodology/approachThe inquiry is informed conceptually by the concept of narrative encounter as a site of learning, with inductive, meta-analysis undertaken across our individual reflective narratives.FindingsThe narratives reveal three emergent themes: shared purpose, shared responsibility – through focus, routinised dialogue and concreteness; collective and individual risk-taking – through negotiated decision-making; and trust in self and in peers – through reciprocity, caring, duality and building on stable practices.Research limitations/implicationsThe data from which this paper is developed and its related central thesis of collegial capital are limited and partial. However, when agility within higher education partnerships is at a premium, this paper is a useful touchstone for further reflection.Originality/valueThe paper seeks to further the concept of collegiality and collegial capital, a dialogical affordance which enabled the partnership to build on previous collaborative successes.
The interconnectedness across risk appetite of distinct investor types in Borsa Istanbul
Authors: Can Ergün Zeliha , Cagli Efe Caglar , Durukan Salı M. Banu 
Published: December 2022

PurposeThis study aims to investigate the interconnectedness across the risk appetite of distinct investor types in Borsa Istanbul. This study also examines the causal impact of global implied volatility indices on the risk appetite of these investor groups.Design/methodology/approachThe authors use a novel time-varying frequency connectedness framework of Chatziantoniou et al. and a new time-varying Granger causality test with a recursive evolving procedure by Shi et al. over June 2008 and July 2022.FindingsThe results show a high level of interconnectedness across the risk appetite of different investor types. The sizable spillovers to domestic types of investors either occur from professional or foreign investors, indicating the long-term dominant effect of foreign and more qualified investors on the domestic investors in Borsa Istanbul. The authors provide significant evidence of causality from the global implied volatility to the Borsa Istanbul risk appetite indices, which are getting stronger after the COVID-19 outbreak.Originality/valueUnlike the previous studies, the authors analyze the risk appetite sub-indices of various types of investors to reveal behavioral distinctions and interconnectedness across them. The authors use a novel econometric framework to assess investors’ risk appetite in different investment horizons in a time-varying system. Together with volatility index (VIX), the authors also use volatilities of oil (OVX), gold (GVZ) and currency (EVZ), considering the information transmission not only from stock markets but also energy, metals and currency markets. The present data set covers significant financial crises, socioeconomic events and the COVID-19 outbreak.
Corporate social responsibility versus business ethics: analysis of employee-related policies
Authors: Furlotti Katia , Mazza Tatiana 
Published: December 2022

Purpose
This study aims to analyze the relationship between companies’ business ethics (BE) and corporate social responsibility (CSR), with particular reference to policies toward employees, with the aim of understanding if and how the two concepts are linked and to foster a better management of the company-employee relationship through BE and CSR policies.

Design/methodology/approach
Through a content analysis, the authors study three issues related to employees disclosed in Code of Ethics (CE) and CSR report of a sample of Italian companies. Next, using a multivariate regression model, the authors examine the relation between the BE and CSR initiatives, related to employees.

Findings
The findings show that CE and CSR initiatives are negatively related. They are distinct concepts, but since the authors find that they are connected, they must also be considered in terms of their mutual dependence. To standardize practices toward employees in a code may induce the need to establish additional corporate social responsibility initiatives that elicit legitimate stakeholder satisfaction.

Research limitations/implications
The analysis focuses on employees, whereas several other CSR aspects that can be explored. Furthermore, additional investigation (through questionnaires or interviews) could deepen this analysis. Furthermore, it might be interesting to consider different countries or more variables, such as cultural differences or different regulations.

Practical implications
The results of this research reveal that BE and CSR initiatives require precise and personalized observations to be properly understood; however, as they are linked, they must also be studied in their mutual interdependencies; this can be very useful to define governance bodies and organizational procedures devoted to BE and CSR issues.

Social implications
This research provides a tool for evaluating and monitoring CSR and BE principles and can be adapted to many business contexts and refer to different stakeholders.

Originality/value
The existing literature on BE and CSR presents opportunities for further study, as these concepts are often studied without insights into their mutual impacts.
Faking it or making it: the politics of consumption and the precariousness of social mobility in South Africa
Authors: Dawson Hannah J. 
Published: December 2022

AbstractThis article critically explores the complex and contradictory meanings attached to conspicuous consumption in an informal settlement on the outskirts of Johannesburg. It examines why un(der)employed young people, especially young Black men, view the trappings of wealth in their midst and dismiss them as ‘fake’. The article shows how the widespread concern with ‘faking it’ indexes the unstable links between consumption, status, and class differentiation in a time of generalized economic insecurity. Accordingly, it maintains that the accusation of ‘fakery’ is not only about jealousy and the dangers of being seen to accumulate money without redistributing it, but also a product of the precariousness that characterizes young people's lives. Ultimately, the article shows how consumption affords a unique window into the values, aspirations, and anxieties of young un(der)employed Black men in a context where ‘proper’ pathways to social mobility are, for most, completely out of reach.
Screening for hazardous alcohol use in the Emergency Department: Comparison of phosphatidylethanol with the Alcohol Use Disorders Identification Test and the Timeline Follow‐back
Authors: Verheij Carolien , Haagsma Juanita A. , Koch Birgit C. P. , Segers Anne E. M. , Schuit Stephanie C. E. , Rood Pleunie P. M. 
Published: December 2022

AbstractBackgroundUp to 15% of all visits to the Emergency Department (ED) are alcohol related. Identification of problematic alcohol use is important in this setting because it allows for intervention and prevention efforts. This study investigated the correlation between the objective phosphatidylethanol (PEth) marker and the subjective Alcohol Use Disorders Identification Test (AUDIT) and Timeline Followback Questionnaire (TLFB) as screening methods for hazardous alcohol use in the general ED population.MethodsThis prospective cohort study included 301 ED patients (57% male) who were seen in the ED and required to give a blood sample. The correlation between the values of PEth (PEth 16:0/18:1 and PEth 16:0/18:2) and the scores on the AUDIT and TLFB were analyzed using Spearman's rank correlation coefficient. Differences between risk categories of PEth and AUDIT were also examined.ResultsThe Spearman correlation coefficients between PEth 16:0/18:1|PEth 16:0/18:2 values and the AUDIT scores were moderate (PEth 16:0/18:1: 0.67, p < 0.001; PEth 16:0/18:2: 0.67, p < 0.001). Of the patients who scored ‘low risk drinking/abstinence’ according to the AUDIT questionnaire, respectively 1% and 4% had PEth 16:0/18:1|PEth 16:0/18:2 values indicating excessive alcohol use, and another 10% and 12% had PEth 16:0/18:1|PEth 16:0/18:2 values indicating moderate alcohol consumption. Of the 12 (PEth 16:0/18:1) and 25 (PEth 16:0/18:2) patients with high‐risk values, respectively 25% and 40% scored in the lowest risk category on the AUDIT questionnaire. Spearman correlation coefficients between PEth 16:0/18:1|PEth 16:0/18:2 values and TLFB two‐week scores were high (PEth 16:0/18:1: 0.74, p < 0.001; PEth 16:0/18:2: 0.82, p < 0.001).ConclusionsAUDIT scores were moderately correlated with PEth values in the general ED population. In almost all cases where there was not a good correlation, patients had high PEth values with low AUDIT scores. We conclude that PEth identifies patients with problematic alcohol use who are missed by the AUDIT questionnaire and therefore PEth could be used as an additional screening method for hazardous alcohol use in this population.
What kind of impacts can artwork have on viewers? Establishing a taxonomy for aesthetic impacts
Authors: Christensen Alexander P. , Cardillo Eileen R. , Chatterjee Anjan 
Published: December 2022

AbstractWhat kinds of impacts can visual art have on a viewer? To identify potential art impacts, we recruited five aesthetics experts from different academic disciplines: art history, neuroscience, philosophy, psychology and theology. Together, the group curated a set of terms that corresponded to descriptive features (124 terms) and cognitive‐affective impacts (69 terms) of artworks. Using these terms as prompts, participants (n = 899) were given one minute to generate words for each term related to how an artwork looked (descriptive features) or made them think or feel (cognitive‐affective impacts). Using network psychometric approaches, we identified terms that were semantically similar based on participants' responses and applied hierarchical exploratory graph analysis to map the relationships between the terms. Our analyses identified 17 descriptive dimensions, which could be further reduced to 5, and 11 impact dimensions, which could be further reduced to 4. The resulting taxonomy demonstrated overlap between the descriptive and impact networks as well as consistency with empirical evidence. This taxonomy could serve as the foundation to empirically evaluate art's impacts on viewers.
Multi‐proxy evidence for rapidly shifting sediment sources to the Taiwan Western Foreland Basin at the Miocene–Pliocene transition
Authors: Hsieh Amy I. , Dashtgard Shahin E. , Wang Pei‐Ling , Horng Chorng‐Shern , Su Chih‐Chieh , Lin Andrew T. , Vaucher Romain , Löwemark Ludvig 
Published: December 2022

AbstractThe Taiwan Western Foreland Basin is thought traditionally to have received sediment mainly from Eurasia until the late Pliocene–early Pleistocene, after which time, the Taiwan orogen became the dominant source. However, a combination of clay mineralogy, δ13Corg and C/N of organic matter, and mass‐specific magnetic susceptibility of late Miocene to early Pliocene strata of the Kueichulin Formation indicate that onset of major sediment contributions from Taiwan occurred much earlier, and correlates closely to the uplift and initial emergence of the Taiwan orogen. Clay mineralogy shows an upsection increase in illite and illite crystallinity, and a decrease in chlorite and kaolinite after the late Miocene, and this is attributed to rapid erosion of the Taiwan orogen. Results from δ13Corg and C/N analyses show that organic material in the Kueichulin Formation changed from dominantly marine to dominantly terrestrial in the early Pliocene, and this is linked to the delivery of large quantities of terrestrial organic material from the Taiwan orogen to the adjacent Taiwan Strait. Magnetic susceptibility also decreases significantly during the early Pliocene, resulting from dilution of magnetic minerals through the influx of non‐magnetic minerals delivered from the Taiwan orogenic belt. The establishment of the growing Taiwan orogen as a major sediment source to the Western Foreland Basin occurred at the Miocene–Pliocene transition, about two million years earlier than previously recognized.
Emergent roles of maternal microchimerism in postnatal development
Authors: Borges Alexandria , Castellan Flore , Irie Naoki 
Published: December 2022

AbstractMaternal microchimerism (MMc) is the phenomenon that a low number of cells from the mother persists within her progeny. Despite their regular presence in mammalian pregnancies, the overall cell type repertoire and roles of maternal cells, especially after birth, remain unclear. By using transgenic mouse strains and human umbilical blood samples, recent studies have for the first time characterized and quantified MMc cell type repertoires in offspring, identified the cross‐generational influence on fetal immunity, and determined possible factors that affect their presence in offspring. This review summarizes new findings, especially on the maternal cell type repertoires and their potential role in utero, in postnatal life, and long after birth.