bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delivering public services to the underserved: Nonprofits and the Latino threat narrative
Authors: Tremblay‐Boire Joannie , Prakash Aseem , Calderon Maria Apolonia 
Published: March 2022

AbstractSome politicians employ harsh rhetoric demanding that government deny public services such as food, housing, and medical care to immigrants. While nonprofits assist immigrants in this regard, their work is sustainable only if private donors support them. Using a survey experiment, this article examines whether donors' willingness to support a charity depends on the legal status of its beneficiaries, and the region from which they have come. We find that, in relation to a charity that serves low‐income families (control group), donors are less willing to support a charity serving immigrants, but the region from which beneficiaries emigrated is irrelevant. Donor willingness diminishes substantially when beneficiaries are undocumented or face deportation. While shared ethnicity between donors and beneficiaries does not increase charitable support, bilingualism does. In addition, support for the charity rises substantially among Latinx donors who were born outside the US and do not speak English at home.
Implementation and evaluation of a virtual dental home educational program
Authors: Ray Melissa , Rogo Ellen , Williams Rachelle 
Published: March 2022

AbstractAimsA Virtual Dental Home (VDH) is an alternative care model using teledentistry technology to provide care in community settings for special care populations. The Dental Hygiene Department at Idaho State University developed a VDH educational program to deliver preventive and therapeutic care at an assisted‐living (AL) facility for memory care residents.The purpose of the educational program was to design and implement a VDH model for AL residents, and subsequently to evaluate the effectiveness of the educational program through students’ knowledge, clinical confidence, and perspectives.Methods and resultsSenior dental hygiene students (n = 32) completed didactic, laboratory, and clinical experiences on implementing an VDH. Using a pretest/posttest design, data were collected using a self‐generated questionnaire; validity and reliability of the questionnaire were established prior to administration. Likert data were analyzed (n = 22, 69%) using the Wilcoxon Signed Rank test and Bonferroni correction.The change in scores of all three variables was statistically significant. The educational program was effective for increasing knowledge, clinical confidence, and perspectives of the dental hygiene students.ConclusionEducational programs that include didactic, laboratory, and clinical experiences prepare graduates for using alternative care models, thereby, enhancing the potential to improve access to care for vulnerable populations in community settings.
For a Du Boisian economic sociology
Authors: Reyes Victoria 
Published: March 2022

AbstractThe discipline is at a crossroads. Will sociology answer ASA past president Aldon Morris' call for an emancipatory sociology? Or will sociology, as Morris puts it, “continue pretending to be an aloof, objective, detached science”? Recently, Hirschman and Garbes issued a call for an economic sociology of race, wherein they contend that race and racism are not central to economic sociology and that economic sociologists don't engage with contemporary race scholarship. In this paper, I assess and build upon their call. I argue that while the article importantly calls for understanding race and racism in economic sociology, in practice, it—used here as an example of a broader pattern within economic sociology—re‐centers whiteness and men, reifies elitism, and erases marginalized scholars and their contributions. I set forth an alternative perspective. To rise to the Du Boisian challenge, scholars need to critique racialized modernity as Itzigsohn and Brown importantly argue. We must also root our sociological consciousness, citation practices, and conversations in existing, yet marginalized, research. Failure to do so means future research risks reproducing inequities in the discipline and continuing to marginalize the very people, theories, and research that an emancipatory sociology is meant to address.
Efficacy and safety of a reduced dose of plerixafor in combination with granulocyte colony‐stimulating factor in healthy haploidentical stem cell donors
Authors: Kurnikova Elena , Trakhtman Pavel , Balashov Dmitry , Garloeva Juliya , Kumukova Irina , Khismatullina Rimma , Pershin Dmitriy , Shelikhova Larisa , Novichkova Galina , Maschan Alexey 
Published: March 2022

AbstractBackground and ObjectivesImplementation of the technique of immunomagnetic selection requires the procurement of a large number of CD34+ cells from haploidentical donors within a single apheresis procedure. The release of stem cells with granulocyte colony‐stimulating factor (G‐CSF) alone is unsatisfactory in a number of donors, and plerixafor, a CXCR4 chemokine receptor antagonist, could be used as an additional mobilization agent. The aim of our study was to examine whether a lower dose of plerixafor (0.12 mg/kg) can provide sufficient increase in CD34+ cells in the peripheral blood of allogeneic healthy donors in comparison with a historical control group. In addition, we assessed the risk of inability to provide the recipient with a transplant containing the optimal dose of 8–10 × 106 CD34+ cells/kg body weight of the recipient.Materials and MethodsIn a prospective, single‐arm study, we examined the results of 105 mobilizations in healthy adult haploidentical donors with G‐CSF and plerixafor at a dose of 0.12 mg/kg. The historical control group consisted of 106 mobilizations with G‐CSF and plerixafor at 0.24 mg/kg.ResultsThe median increase in the number of CD34+ cells from day 4 to day 5 of mobilization was 69 cells/μl (range, 28–240) versus 77 cells/μl (24–217) in the groups of 0.12 and 0.24 mg/kg of plerixafor, respectively (p‐value 0.255). The apheresis products contained a median of 14.4 × 106/kg recipient body weight CD34+ cells versus 12.9 × 106/kg in the groups that received 0.12 and 0.24 mg/kg of plerixafor, respectively (p‐value 0.118). The obtained differences were not significant, which means the application of a decreased dose of plerixafor did not affect the results of mobilization.ConclusionThe obtained differences in collection were not significant, and thus the application of a decreased dose of plerixafor did not affect the results of mobilization.
Development of an Air-Cooled Induction Manifold for Diesel Engines in Hot and Humid Climate
Authors: Elrentisy Mohamed H. , Abdellatif Yasser M. , Elbashir Aboubaker M. , Ahmed Samer F. 
Published: March 2022

Abstract
Extreme weather conditions in the Gulf, Qatar, have been taken as an example in this study, tend to be hot and humid mostly throughout the year, especially in the summer. Such weather negatively affects the performance and emissions of all combustion engines, in particular diesel engines. In this work, a modified air-conditioning system was designed for controlling the inlet air temperature and humidity of a naturally aspirated single-cylinder diesel engine. The study investigated the effect of running the engine at different controlled inlet air temperatures on the engine performance and emission characteristics. It was found that running the diesel engine at 20 °C inlet air temperature compared with 45 °C, the average ambient air temperature during summer in Qatar could increase the in-cylinder peak pressure by 10%, and the volumetric efficiency of the engine by 8.5%. Moreover, the air-to-fuel (A/F) ratio has increased by 27.5% with 20 °C compared with 45 °C, while a minor effect was observed on the specific fuel consumption. For the emissions, there was a considerable reduction rate in NOx emissions with about 83% at 20 °C as well as a 50% reduction in hydrocarbon (HC) emissions compared with 45 °C. Furthermore, the smoke emission has decreased by 40% at the engine full load. It was also proved that using the air-conditioning system of a vehicle to cool the intake air temperature is visible, as the net gained the power of the engine has increased by 14.5% when running at 20 °C compared with 45 °C.
Physics-Based Reduced-Order Model for Liquid Ring Pumps
Authors: Pandey Ashutosh , Shih Tom I-P. 
Published: March 2022

Abstract
Liquid-ring vacuum pumps, by not having solid-solid contacts at interfaces where moving and stationary parts meet, are efficient and robust with considerable potential for further improvements on efficiency, performance, and range of operations. In this study, a physics-based reduced order model was developed for the preliminary design of liquid-ring pumps. The model developed accounts for the dominant physical processes created by the pump's key design and operating parameters: eccentricity, impeller-tip radius, impeller-hub radius, pressure at the pump's inlet and exit, and the impeller's rotational speed. The model developed can predict the shape of the liquid ring, the amount of air ingested and discharged by the pump, the power consumed by the pump as well as the pressure of the gas and liquid in the pump between the blades of the impeller as a function of those design and operating parameters. The predictions made by the model on the flow rates of the gas ingested by the pump and the power consumed by the pump were compared with experimental data, and good agreements were found.
Parametric Effects on Pool Boiling Heat Transfer and Critical Heat Flux: A Critical Review
Authors: Emir Tolga , Ourabi Hamza , Budakli Mete , Arik Mehmet 
Published: March 2022

Abstract
Pool boiling heat transfer offers high-performance cooling opportunities for thermal problems of electronics limited with high heat fluxes. Therefore, many researchers have been extensively studying over the last six decades. This paper presents a critical literature review of various parametric effects on pool boiling heat transfer and critical heat flux (CHF) such as pressure, subcooling, surface topography, surface orientation, working fluid, and combined effects. To achieve an optimal heat removal solution for a particular problem, each of these parameters must be understood. The governing mechanisms are discussed separately, and various options related to the selection of appropriate working fluids are highlighted. A broad summary of correlations developed until now for predicting CHF is presented with their ranges of validity. While proposed correlations for predicting CHF have been quite promising, they still have a considerable uncertainty (±25%). Finally, a correlation proposed by Professor Avram Bar-Cohen and his team (thermal management of electronics (TME) correlation) is compared with the experimental dataset published in previous studies. It shows that the uncertainty band can be further narrowed down to ±12.5% for dielectric liquids by using TME correlation. Furthermore, this correlation has been enhanced to predict CHF values underwater above 50 W/cm2 by applying a genetic algorithm, and new perspectives for possible future research activities are proposed.
Overtraining Syndrome Symptoms and Diagnosis in Athletes: Where Is the Research? A Systematic Review
Authors: Weakley Jonathon , Halson Shona L. , Mujika Iñigo 
Published: March 2022

Context: To understand overtraining syndrome (OTS), it is important to detail the physiological and psychological changes that occur in athletes. Objectives: To systematically establish and detail the physiological and psychological changes that occur as a result of OTS in athletes. Methods: Databases were searched for studies that were (1) original investigations; (2) English, full-text articles; (3) published in peer-reviewed journals; (4) investigations into adult humans and provided (5) objective evidence that detailed changes in performance from prior to the onset of OTS diagnosis and that performance was suppressed for more than 4 weeks and (6) objective evidence of psychological symptoms. Results: Zero studies provided objective evidence of detailed changes in performance from prior to the onset of OTS diagnosis and demonstrated suppressed performance for more than 4 weeks accompanied by changes in psychological symptoms. Conclusions: All studies failed to provide evidence of changes in performance and mood from “healthy” to an overtrained state with evidence of prolonged suppression of performance. While OTS may be observed in the field, little data is available describing how physiological and psychological symptoms manifest. This stems from vague terminology, difficulties in monitoring for prolonged periods of time, and the need for prospective testing. Real-world settings may facilitate the collection of such data, but the ideal testing battery that can easily be conducted on a regular basis does not yet exist. Consequently, it must be concluded that an evidence base of sufficient scientific quality for understanding OTS in athletes is lacking.
Heat Adaptation and Nutrition Practices: Athlete and Practitioner Knowledge and Use
Authors: Alabdulwahed Salma , Galán-López Natalia , Hill Tom , James Lewis J. , Chrismas Bryna Catherine Rose , Racinais Sebastien , Stellingwerff Trent , Leal Diogo V. , Hausen Matheus , Chamari Karim , Fullagar Hugh H.K. , Esh Christopher , Taylor Lee 
Published: March 2022

Purpose: To survey elite athletes and practitioners to identify (1) knowledge and application of heat acclimation/acclimatization (HA) interventions, (2) barriers to HA application, and (3) nutritional practices supporting HA. Methods: Elite athletes (n = 55) and practitioners (n = 99) completed an online survey. Mann–Whitney U tests (effect size [ES; r]) assessed differences between ROLE (athletes vs practitioners) and CLIMATE (hot vs temperate). Logistic regression and Pearson chi-square (ES Phi [ϕ]) assessed relationships. Results: Practitioners were more likely to report measuring athletes’ core temperature (training: practitioners 40% [athletes 15%]; P = .001, odds ratio = 4.0, 95% CI, 2%–9%; competition: practitioners 25% [athletes 9%]; P = .020, odds ratio = 3.4, 95% CI, 1%–10%). Practitioners (55% [15% athletes]) were more likely to perceive rectal as the gold standard core temperature measurement site (P = .013, ϕ = .49, medium ES). Temperate (57% [22% hot]) CLIMATE dwellers ranked active HA effectiveness higher (P < .001, r = .30, medium ES). Practitioners commonly identified athletes’ preference (48%), accessibility, and cost (both 47%) as barriers to HA. Increasing carbohydrate intake when training in the heat was more likely recommended by practitioners (49%) than adopted by athletes (26%; P = .006, 95% CI, 0.1%–1%). Practitioners (56% [28% athletes]) were more likely to plan athletes’ daily fluid strategies, adopting a preplanned approach (P = .001; 95% CI, 0.1%–1%). Conclusions: Practitioners, and to a greater extent athletes, lacked self-reported key HA knowledge (eg, core temperature assessment/monitoring methods) yet demonstrated comparatively more appropriate nutritional practices (eg, hydration).
On the Nature of Individual Variation in Diapause Induction among the Progeny of Trichogramma telengai Sor. (Hymenoptera, Trichogrammatidae)
Authors: Voinovich N. D. , Reznik S. Ya. 
Published: March 2022

Abstract
In this communication, we analyze the variation in diapause incidence among isofemale substrains of the main laboratory strain of Trichogramma telengai Sor. (Hymenoptera, Trichogrammatidae) in order to clarify the nature of the previously discovered individual (intrastrain) variation in this trait. During the experiment, the maternal generation developed at a temperature of 20°C under a day length of either 12 or 18 h, and diapause in the progeny was induced by development at 14°C in darkness. In total, the experiment comprised eight replicates in which female diapause incidence was measured in 428 substrains in two consecutive generations. There was statistically significant individual (first-generation) and interfamilial (second-generation) variation in almost all of the replicates. However, the correlation between the diapause incidence values among the progeny of two consecutive generations of the same substrains was weak and largely nonsignificant. These results suggest that intrastrain variation in the percentage of diapausing progeny of T. telengai females is not primarily produced by genetic (hereditary) factors but is due to certain environmental (nonhereditary) effects.
‘Persistent throat symptoms’ versus ‘laryngopharyngeal reflux’: a cross-sectional study refining the clinical condition
Authors: O'Hara James , Fisher Holly , Hayes Louise , Wilson Janet 
Published: March 2022

ObjectiveMany patients are assessed for chronic symptoms including: dysphonia, ‘globus’, throat clearing, postnasal secretions and cough; commonly grouped together and attributed to ‘laryngopharyngeal reflux’. This study aimed to explore a clinical trial’s baseline dataset for patterns of presenting symptoms, which might provide a more rational basis for treatment.DesignBaseline data were analysed for participants entering the Trial Of Proton-Pump Inhibitors in Throat Symptoms: age, body mass index, Reflux Symptom Index, Comprehensive Reflux Symptom Score, Laryngopharyngeal Reflux-Health-related Quality of Life questionnaire and Reflux Finding Score (RFS-endoscopic examination). The relationships between the questionnaires and demographic factors were assessed. Exploratory factor analysis (EFA) was conducted on individual symptom items in the combined questionnaires. The EFA factors were applied to a Cluster Analysis of participants, to explore the presence of identifiable patient.ResultsThroat clearing and globus were the highest ranked scores in the 344 participants. Increasing age was inversely associated with symptom severity (p<0.01). There was no relationship between the RFS and any of the three questionnaires. EFA resulted in a seven-factor model with clinically meaningful labels: voice, cough, gastrointestinal symptoms, airway symptoms and dysphagia, throat clearing, lump in throat, and life events. Cluster analysis failed to demonstrate any clinically meaningful clusters of patients.ConclusionThis study offers a framework for future research and demonstrates that individual symptoms cannot be used to group patients. The analysis supports the use of a broad ‘umbrella’ term such as persistent throat symptoms.Trial registration numberISRCTN38578686.
Immunosuppressive tumor-associated macrophages expressing interlukin-10 conferred poor prognosis and therapeutic vulnerability in patients with muscle-invasive bladder cancer
Authors: Xu Yijia , Zeng Han , Jin Kaifeng , Liu Zhaopei , Zhu Yu , Xu Le , Wang Zewei , Chang Yuan , Xu Jiejie 
Published: March 2022

BackgroundTumor-associated macrophages (TAMs) secreting IL-10 could be a specific functional cell subset with distinct polarization state and suppressive role in antitumor immune response. Here, we assessed the associations of clinical outcome, therapeutic responses and molecular features with IL-10+TAMs infiltration, and potential impact of IL-10+TAMs on the immune contexture in muscle-invasive bladder cancer (MIBC).MethodsIn this retrospective study, 128 patients and 391 patients with MIBC from Zhongshan hospital (ZS cohort) and The Cancer Genome Atlas cohort were included respectively. Immunohistochemistry was performed to quantify various immune cell infiltration in the ZS cohort. Single cell RNA sequencing and flow cytometry were performed to examine the functional status of IL-10+TAMs and its correlation with other immune cells. Survival analyses and assessment of the adjuvant chemotherapy (ACT) benefit analyses were also performed.ResultsHigh IL-10+TAMs infiltration was associated with inferior prognosis in terms of overall survival and recurrence-free survival, but superior chemotherapeutic response in MIBC. IL-10+TAMs with suppressive features were associated with immunoevasive tumor microenviroment characterized by exhausted CD8+T cells, immature NK cells and increased immune checkpoint expression. Additionally, high IL-10+TAMs infiltration showed a strong linkage with basal-featured subtype and augmented EGF signaling.ConclusionsImmunosuppresive IL-10+TAMs contributed to an evasive contexture with incapacitated immune effector cells and increased immune checkpoint expression, therefore, predicting unfavorable clinical outcomes despite better ACT responsiveness. IL-10+TAMs might provide guidance for customized selection of EGFR-targeted therapy, FGFR3-targeted therapy as well as immunotherapy. The potential of immunosuppressive IL-10+TAMs as a therapeutic target is worth further exploration.
Development of a TCR-like antibody and chimeric antigen receptor against NY-ESO-1/HLA-A2 for cancer immunotherapy
Authors: Liu Xin , Xu Yixiang , Xiong Wei , Yin Bingnan , Huang Yuqian , Chu Junjun , Xing Changsheng , Qian Chen , Du Yang , Duan Tianhao , Wang Helen Y , Zhang Ningyan , Yu John S. , An Zhiqiang , Wang Rongfu 
Published: March 2022

BackgroundThe current therapeutic antibodies and chimeric antigen receptor (CAR) T cells are capable of recognizing surface antigens, but not of intracellular proteins, thus limiting the target coverage for drug development. To mimic the feature of T-cell receptor (TCR) that recognizes the complex of major histocompatibility class I and peptide on the cell surface derived from the processed intracellular antigen, we used NY-ESO-1, a cancer-testis antigen, to develop a TCR-like fully human IgG1 antibody and its derivative, CAR-T cells, for cancer immunotherapy.MethodsHuman single-chain variable antibody fragment (scFv) phage library (~10∧11) was screened against HLA-A2/NY-ESO-1 (peptide 157–165) complex to obtain target-specific antibodies. The specificity and affinity of those antibodies were characterized by flow cytometry, ELISA, biolayer interferometry, and confocal imaging. The biological functions of CAR-T cells were evaluated against target tumor cells in vitro. In vivo antitumor activity was investigated in a triple-negative breast cancer (TNBC) model and primary melanoma tumor model in immunocompromised mice.ResultsMonoclonal antibody 2D2 identified from phage-displayed library specifically bound to NY-ESO-1157-165in the context of human leukocyte antigen HLA-A*02:01 but not to non-A2 or NY-ESO-1 negative cells. The second-generation CAR-T cells engineered from 2D2 specifically recognized and eliminated A2+/NY-ESO-1+tumor cells in vitro, inhibited tumor growth, and prolonged the overall survival of mice in TNBC and primary melanoma tumor model in vivo.ConclusionsThis study showed the specificity of the antibody identified from human scFv phage library and demonstrated the potential antitumor activity by TCR-like CAR-T cells both in vitro and in vivo, warranting further preclinical and clinical evaluation of the TCR-like antibody in patients. The generation of TCR-like antibody and its CAR-T cells provides the state-of-the-art platform and proof-of-concept validation to broaden the scope of target antigen recognition and sheds light on the development of novel therapeutics for cancer immunotherapy.