bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive analysis of the glutathione S-transferase Mu (GSTM) gene family in ovarian cancer identifies prognostic and expression significance
Authors: Zhang Juan , Li Yan , Zou Juan , Lai Chun-tian , Zeng Tian , Peng Juan , Zou Wen-da , Cao Bei , Liu Dan , Zhu Li-yu , Li Hui , Li Yu-kun 
Published: July 2022

BackgroundOvarian cancer (OC) is one of the most common types of gynecologic tumor over the world. The Glutathione S-transferase Mu (GSTM) has five members, including GSTM1-5. These GSTMs is involved in cell metabolism and detoxification, but their role in OC remains unknown.MethodsData from multiple public databases associated with OC and GSTMs were collected. Expression, prognosis, function enrichment, immune infiltration, stemness index, and drug sensitivity analysis was utilized to identify the roles of GSTMs in OC progression. RT-qPCR analysis confirmed the effect of AICAR, AT-7519, PHA-793887 and PI-103 on the mRNA levels of GSTM3/4.ResultsGSTM1-5 were decreased in OC samples compared to normal ovary samples. GSTM1/5 were positively correlated with OC prognosis, but GSTM3 was negatively correlated with OC prognosis. Function enrichment analysis indicated GSTMs were involved in glutathione metabolism, drug metabolism, and drug resistance. Immune infiltration analysis indicated GSTM2/3/4 promoted immune escape in OC. GSTM5 was significantly correlated with OC stemness index. GSTM3/4 were remarkedly associated with OC chemoresistance, especially in AICAR, AT-7519, PHA-793887 and PI-103.ConclusionGSTM3 was negatively correlated with OC prognosis, and associated with OC chemoresistance and immune escape. This gene may serve as potential prognostic biomarkers and therapeutic target for OC patients.
Moderate grade subglottic stenosis in children: Laryngotracheal reconstruction versus cricotracheal resection and anastomosis
Authors: Beatrix Christina Kokje Vivianne , Ishii Alessandro , Sandu Kishore 
Published: July 2022

ObjectiveThe surgical treatment of choice of pediatric moderate subglottic stenosis (major grade II and minor grade III SGS or 60–80% lumen obstruction) remains controversial. Laryngotracheal reconstruction (LTR) (with anterior ± posterior grafts for airway expansion) and partial crico-tracheal resection (PCTR) are the mainly described open surgical techniques. We reviewed our pediatric cases with moderate subglottic stenosis to determine the efficacy of LTR versus PCTR.MethodsA retrospective study of all children between 0 and 18 years that underwent open reconstructive airway surgery between 2012 and 2019. Children who had either acquired or congenital moderate subglottic stenosis (late grade II and early grade III: 60–80% lumen obstruction) were selected.ResultsTwenty-six children with moderate-grade subglottic stenosis were included. Seventeen were treated with LTR and nine with PCTR. No significant differences were observed between LTR and PCTR-treated cases. Decannulation rates were similar, as well as the functional results.ConclusionBoth LTR and PCTR are valid treatment options for moderate subglottic stenosis. This study indicates to perform the surgery that is most suitable for the characteristics of the patients’ stenosis, the surgeons’ expertise and preference, and the working infrastructure.
Effectiveness of Polidocanol in the Treatment of Venous Malformations: A Meta-Analysis
Authors: Hu Wei , Liu Zhuang , Sun Jiali , Wang Liang , Song Dan , Guo Lei 
Published: July 2022

ObjectiveThe aim of this study was to investigate the efficacy of polidocanol against venous malformations (VMs).MethodsStudies reporting the treatment of VMs using polidocanol (published until February 15, 2020) were reviewed in the Embase and PubMed databases. After excluding the same literature, part of the studies were excluded by reading the title, abstract, full text. Eleven studies (with 287 participants) that fulfilled the inclusion criteria were included. Systematic meta-analysis was performed using Reviews Manager 5.2, and a fixed-effects model was used to calculate the pooled effective rate of polidocanol against VMs and the 95% confidence intervals (CI).ResultsLesion reduction of more than 50% was considered effective. A total of 287 patients were treated, and treatment in 271 was considered effective. The efficacy of polidocanol was 0.89 (95% CI = 0.83–0.93). Heterogeneity among the studies was small (I2 = 0%, P = 0.47). T The funnel plot was roughly symmetric.ConclusionOur study suggested that polidocanol is effective in the treatment of VMs. VMs at different sites can be treated without serious complications. Therefore, we have reason to believe that polidocanol is a safe and an effective drug for VMs.
Clinical characteristics and mortality predictors of patients with cancer hospitalized by COVID-19 in a pediatric third-level referral center
Authors: Hernández-Regino Laura-Monserrat , De Jesús Castillejos-López Manuel , Aquino-Gálvez Arnoldo , Velasco-Hidalgo Liliana , García-Guzmán Alda , Aguilar-Ortiz Marco , Cárdenas-Cardos Rocío , Torres-Espíndola Luz María 
Published: July 2022

BackgroundMore than 135 million COVID-19 cases (coronavirus disease 2019) have been reported worldwide until today, with over 2.9 million deaths. Several studies have demonstrated that disease severity is lower in the pediatric population than in adults; however, differences are described in patients with chronic diseases, including oncological patients. Current world literature suggests patients with comorbidities, including cancer, have an increased risk of unfortunate outcomes. Therefore, our objective was to describe the clinical characteristics and epidemiological factors associated with mortality in a cohort of pediatric cancer patients hospitalized for COVID-19.MethodsThis is a retrospective, descriptive study of the cases of patients with cancer hospitalized for COVID-19. A total of 40 pediatrics were included in the analysis. Data from pediatric patients with COVID-19 included clinical and epidemiological records, laboratory, imaging studies, COVID-19 diagnostic methods, and medical treatment.ResultsOf the 40 pediatric patients admitted with cancer with a confirmed diagnosis of COVID-19, 42.5% were solid tumors, 40% leukemias, and 17.5% lymphomas. The clinical parameters associated with mortality were stage IV tumor (p = 0.029) and intubation (p &lt; 0.001). The biochemical factors associated with lower survival were thrombocytopenia under 25,000 cells/mm3 (p &lt; 0.001), D-dimer over 1 μg/ml (p = 0.003), clinical malnutrition (p = 0.023), and disseminated intravascular coagulation (p = 0.03).ConclusionOur findings showed that the fever was the most frequent symptom, and the clinical parameters associated with mortality were stage IV tumor, intubation, saturation percentage, RDW, platelets, creatinine, ALT, D-dimer, ferritin, and FiO2 percentage. The thrombocytopenia, D-dimer, nutritional status, and disseminated intravascular coagulation were significantly associated with lower survival.
Strategies for intraoperative management of the trigeminal nerve and long-term follow-up outcomes in patients with trigeminal neuralgia secondary to an intracranial epidermoid cyst
Authors: Zhang Zhenyu , Wang Wenhua , Yu Feng , Kwok Sze Chai , Wang Yuhai , Yin Jia 
Published: July 2022

BackgroundEpidermoid cysts (ECs) are one of the most common causes of secondary trigeminal neuralgia (TGN). However, most previous studies have primarily focused on whether complete tumor resection was achieved, and few studies have discussed the primary goal of pain relief.ObjectiveThe present study provides intraoperative strategies for trigeminal nerve (TN) management in patients with TGN secondary to an EC and observed long-term follow-up outcomes.MethodsA total of 69 patients with TGN secondary to an EC at our hospitals were included (January 2011–June 2021). The same surgical team performed all surgeries using a retrosigmoid approach. After EC removal, different methods for TN management were used, including microvascular decompression (MVD), sharp capsulectomy, nerve combing and embedded cholesterol crystal excision. The epidemiological, clinical, and surgical data were extracted.ResultsThe total EC removal rate was 92.8% (64/69). All patients achieved initial pain relief postoperatively, and 12 patients (17.4%) experienced varying degrees of hemifacial hypesthesia, which was relieved within 3–6 months. Three patients (4.3%) reported partial pain recurrence within a median follow-up period of 5.5 (0.5–10.5) years, which was relieved completely after low-dose carbamazepine administration.ConclusionThe primary goal of surgical tumor removal for patients with TGN secondary to an EC is relief of the main symptom of tormenting pain. The selection of an appropriate strategy for TN, including MVD, sharp capsulectomy, nerve combing or embedded cholesterol crystal excision, should depend on the patient's situation.
B-learning como estrategia para mejorar el aprendizaje de un idioma extranjero en estudiantes de Educación Básica de la Unidad Educativa Jean Piaget
Authors: Castillo Medranda Eliana Melissa , Tubay Álvarez María Elena 
Published: July 2022

El aprendizaje de un idioma extranjero forma parte importante en la formación integral de los educandos y se lleva a la práctica dentro del aula de clases, por lo que el estudiante tiene la oportunidad de su formación en una lengua ajena a la materna en un espacio y tiempo limitado, restringiéndose su práctica fuera del aula. Desde la noción precedente se planteó como objetivo general, determinar la influencia del método Blended-learning al mejoramiento del aprendizaje de un idioma extranjero en estudiantes de educación básica de la Unidad Educativa Jean Piaget. 2019, para dar cumplimiento a lo propuesto se utilizó un tipo de investigación mixta, con técnicas cualitativas, aplicación de un diagnóstico FODA (Fortalezas, Oportunidades, Debilidades, Amenazas), y cuantitativas con encuesta online. Entre las principales conclusiones se destaca que el análisis FODA, aplicado a la Unidad Educativa Jean Piaget y la encuesta online a los estudiantes, sirvieron de base para comprender como influyen las TIC, en los procesos de enseñanza aprendizaje, y debido a que los estudiantes son considerados como una generación de nativos digitales, están predispuestos a utilizar herramientas tecnológicas como el B-learning, con el fin de obtener más y mejores competencias en el aprendizaje de un idioma extranjero.
PALABRAS CLAVE: Idioma extranjero; herramientas tecnológicas; estudiantes; TIC; b-learning.
B-learning as a strategy to improve the learning of a foreign language in Basic Education students of the Jean Piaget Educational Unit
ABSTRACT
The learning of a foreign language is an important part of the comprehensive training of students and is put into practice in the classroom, so that the student can learn in a foreign language to the mother tongue in a space and limited time, restricting their practice outside the classroom. From the previous notion, the general objective was to determine the influence of the Blended-learning method to improve the learning of a foreign language in basic education students of the Jean Piaget Educational Unit. 2019, to comply with the proposal, a type of mixed research was used, with qualitative techniques, application of a SWOT diagnosis (Strengths, Weaknesses, Opportunities, Threats), and quantitative techniques with an online survey. Among the main conclusions, it is highlighted that the SWOT analysis, applied to the Jean Piaget Educational Unit and the online survey of students, served as the basis for understanding how ICTs influence the teaching-learning processes, and because students are considered as a generation of digital natives, they are predisposed to use technological tools such as B-learning, to obtain more and better skills in learning a foreign language.
KEYWORDS: Foreign language; technological tools; student; TIC; b-learning.
Estudio de disponibilidad léxica en alumnos de primer año de la carrera de Periodismo de la Universidad de Matanzas, Cuba
Authors: Perdomo Casanova Noraida , Domínguez García Ileana , Alfonso Ramos Rosa Elvira 
Published: July 2022

Este artículo presenta los resultados del léxico disponible en dieciocho centros de interés, de los estudiantes de primer año de la carrera de Periodismo y valora el léxico individual de cada informante. La metodología empleada es la del Proyecto Panhispánico. La información se procesó a través de la base de datos de Dispolex y se utilizó el lenguaje de programación R©, para determinar la disponibilidad léxica individual. La investigación realizada demostró que los estudios lexicométricos de disponibilidad léxica continúan siendo una herramienta importante de la Lingüística aplicada a la Didáctica de la lengua materna porque además de poder determinar el índice de disponibilidad de un vocablo, así como el léxico disponible de una comunidad; también se puede evaluar el desarrollo léxico de los aprendices en un determinado período.
PALABRAS CLAVE: léxico disponible; léxico individual; desarrollo léxico.
LEXICAL AVAILABILITY STUDY IN FIRST YEAR STUDENTS OF THE JOURNALISM DEGREE AT THE UNIVERSITY OF MATANZAS. CUBA
ABSTRACT
This article presents the results of the available lexicon in eighteen centers of interest, among first-year journalism students, and evaluates the individual lexicon of each participant. The methodology used was that of the Panhispanic Project. The information was processed through the Dispolex database and the R© programming language was used to determine the individual lexical availability. The research carried out showed that lexicometric studies of lexical availability are still an important tool of Linguistics applied to the Didactics of the mother tongue because besides making possible to determine the index of availability of a word, as well as the available lexicon of a community; it makes also possible to evaluate the lexical development of the learners in a given period.
KEYWORDS: available lexicon; individual lexicon; lexicon development.
COVID-19 y los desafíos de la docencia infantil en Ecuador
Authors: Sánchez Salazar Doménica Anthonella , Mayla Cajisaca Nathaly Silvana , Guerrón Varela Edgar Ramiro , Garcés Alencastro Alejandra Cristina 
Published: July 2022

La presente investigación busca conocer los desafíos de la docencia infantil en Ecuador, en el marco de la pandemia COVID-19. Para ello se recolectaron datos por medio de la aplicación de una encuesta dirigida a 230 docentes de niños de 3-6 años. El estudio es de modalidad bibliográfica, nivel correlacional, descriptivo, con enfoque cuantitativo y cualitativo. Para el análisis de datos se empleó el chi-cuadrado y V. de Cramer, para identificar el nivel de dependencia entre variables. En conclusión, se determinó la dependencia del acompañamiento de padres con la participación de los niños en clase y de las actividades de interacción con el nivel de logro en el ámbito curricular de convivencia. A su vez, no se evidenció la asociación esperada entre la incorporación de las TICs en la comunicación con la interacción docente-alumno, ni en el número de estrategias empleadas con el nivel de participación de clase.
PALABRAS CLAVE: Docencia; educación infantil; ambientes virtuales; tecnología; COVID-19.
COVID-19 and the challenges of teaching children in Ecuador
ABSTRACT
This research seeks to understand the challenges of early childhood education in Ecuador, in the framework of the COVID-19 pandemic. For that reason, data were collected through the application of a survey directed to 230 teachers of children aged 3-6 years. The study is of bibliographic modality, correlational level, descriptive, with a quantitative and qualitative approach. Chi-square and V. Cramer were used for data analysis to identify the level of dependence between variables. In conclusion, the dependence of the accompaniment of parents with the participation of the children in class and of the interaction activities with the level of achievement in the curricular area of ​​coexistence was determined. At the same time, the expected association between the incorporation of ICTs in communication and teacher-student interaction was not evidenced, nor was the number of strategies used with the level of class participation.
KEYWORDS: Teaching; early childhood education; virtual environments; technology; COVID-19.
Análisis empírico sobre la interacción de los estudiantes y elementos académicos en un curso infantil durante el confinamiento
Authors: Venegas Leslie Johanna , Analuisa Maiguashca Jessica Carolina , Larrea Astudillo Nelly Carolina , Cruz Báez Estefanía Rocío 
Published: July 2022

El problema actual sobre la pandemia mundial acerca del Covid-19 tuvo un impacto en la cotidianidad escolar, lo que permitió el uso de plataformas digitales y el origen de programas educativos virtuales; por ello se creó el curso denominado Ciencia, experimentos y arte infantil compuesto de los módulos Pequeños científicos y Pequeños artistas. El objetivo de la investigación es analizar la interacción de los usuarios con elementos académicos entre los cuales están recursos educativos, tareas y evaluaciones. La metodología utilizada fue cuantitativa, con diseño no experimental, tipo de muestreo no probabilístico y por conveniencia. Se trabajó con una muestra de 348 niños de todas las provincias del Ecuador en edades de 5 a 7 años, los datos se recopilaron por medio de los registros de navegación que se representaron a través de sociogramas. Entre los resultados obtenidos, está que el módulo con mayor participación es Pequeños científicos y la interactividad en elementos académicos se desarrolla con mayor porcentaje en los recursos educativos de los dos módulos. Como conclusión se manifiesta que la temática que llamó más la atención es experimentos y ciencia; además se requiere planificación de actividades y acompañamiento de tutores para mayor interacción en cursos virtuales infantiles.
PALABRAS CLAVE: TIC, educación, primera infancia, innovación educacional.
Empirical analysis on the interaction of students and academic elements in a children's course during confinement.
ABSTRACT
The current problem with the global covid-19 pandemic had an impact on school daily life, which allowed the use of digital platforms and the origin of virtual educational programs; that is why the course Ciencia, experimentos y arte infantil composed of Pequeños científicos and Pequeños artistas modules was created. The objective of the research is to analyze the interaction of users with academic elements among which are educational resources, tasks, and evaluations. The methodology used was quantitative, with non-experimental design, type of non-probabilistic sampling and for convenience. A sample of 348 children from all provinces of Ecuador at ages 5 to 7 years were worked on, the data collected through navigation logs that were represented through sociograms. Among the results obtained, this is that the module with the greatest participation is Pequeños científicos and the interactivity in academic elements develops with a higher percentage in the educational resources of the two modules. As a conclusion it is manifested that the theme catches the most attention is experiments and science; In addition, planning of activities and accompanying tutors is required for greater interaction in virtual children's courses.
KEYWORDS: ICT; education; early childhood; educational innovation.
Estudio documental de la motivación en Educación Física: análisis de su evolución
Authors: Galeano-Terán Alex 
Published: July 2022

Durante el proceso enseñanza aprendizaje la motivación ha sido analizada desde varias perspectivas científicas, estudios que han dado mayor importancia a la relación de los aspectos cognitivos y motivacionales en educación, por ello resulta fundamental conocer los principales instrumentos que permiten evaluar la motivación de los estudiantes. Este trabajo tiene como objetivo: Analizar aspectos importantes de la motivación, conocer su concepto definiéndolo a partir de concepciones de diferentes autores y precursores del estudio de la motivación hasta llegar a la aplicación en Educación Física. Posteriormente se examinaron los modelos explicativos y teóricos, así como los primeros autores que estudiaron la motivación, formas de evaluación, medición; y los beneficios que tiene en la práctica deportiva de la educación Física. La presente investigación utilizó como técnica de recolección de datos, el análisis documental cualitativo a través del estudio de los principales instrumentos de evaluación y teorías de la motivación, examinando las principales bases de datos bibliográficas que recaban información científica como Dialnet, Web of Science y Scopus. Con el análisis realizado y la información obtenida se conoció la evolución y concepto de motivación, las principales teorías activas y reactivas y los principales instrumentos de evaluación aplicables a la Educación Física.
PALABRAS CLAVE: Motivación; Educación Física; Evaluación de la Motivación; Evolución de Motivación.
Documentary study of motivation in Physical Education
ABSTRACT
During the teaching-learning process, motivation has been analyzed from several scientific perspectives, studies that have given greater importance to the relationship of cognitive and motivational aspects in education, therefore it is essential to know the main instruments that allow evaluating student motivation. This work aims to: Analyze important aspects of motivation, know its concept defining it from the conceptions of different authors and precursors of the study of motivation until it reaches its application in Physical Education. Later the explanatory and theoretical models were examined as well as the first authors who studied the motivation, forms of evaluation, measurement; and the benefits that Physical education has in sports practice. This research used as a data collection technique, qualitative documentary analysis through the study of the main assessment instruments and motivation theories, examining the main bibliographic databases that collect scientific information such as Dialnet, Web of Science and Scopus. With the analysis carried out and the information obtained, the evolution and concept of motivation, the main active and reactive theories and the main evaluation instruments applicable to Physical Education were known.
KEYWORDS: Motivation; Physical education; Motivation Assessment; Evolution of Motivation.
Incidencia de ácaros en la pudrición de vaina en dos variedades de arroz (Oryza sativa L)
Authors: Durán Mera Christian Alejandro , Vivas Vivas María Leticia , RIVERA PIZARRO VICTOR HUGO 
Published: July 2022

La pudrición de la vaina causada por Sarocladium oryzae, es una enfermedad que afecta al cultivo de arroz (Oryza sativa L), se relaciona por presencia del ácaro Steneotarsonemus spinki y aplicaciones excesivas de nitrógeno ya que en cantidades elevadas atrae al ácaro. El objetivo fue determinar la población de ácaros en dos variedades de arroz bajo la incidencia de la pudrición de la vaina, fertilización nitrogenada más la aplicación con y sin acaricida más rendimiento. Se utilizó un diseño de parcelas divididas con dos variedades de arroz, tres dosis de nitrógeno y dos aplicaciones de acaricida lo que totalizó 12 tratamientos con tres repeticiones para un total de 36 parcelas evaluadas. Las variables fueron números de ácaros tetraníquidos, predatores y tarsonémidos, porcentajes de espigas afectadas y rendimiento kg ha-1. Los resultados demostraron que la mayor cantidad de ácaros encontrados fueron 124 predatores en tres evaluaciones realizadas, el porcentaje de espigas afectadas 12% y rendimientos superaron 2500 kg ha-1, además no se pudo relacionar la presencia de la enfermedad con el ácaro Steneotarsonemus spinki debido a que solo se encontró un individuo.

Palabras clave: Sarocladium oryzae; Steneotarsonemus spinki; rendimiento.