bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medical management of small uterocutaneous fistulae with gonadotrophin releasing hormone analogs: Case report and literature review
Authors: Sanjuan Carles Raul , Sharif Shehzad , Rodriguez Arias Jesus , Berg Lauren , Nakhosteen Ali , Yoong Wai 
Published: November 2022

AbstractConventional management of uterocutaneous fistula involves open or laparoscopic excision as well as hysterectomy but there is now increasing recognition of successful medical treatment with gonadotrophin releasing hormone agonists. We describe the fourth case in the literature of successful nonsurgical treatment of uterocutaneous fistula and discuss two important factors affect the success of medical management, namely the size of the fistula and the duration of treatment. We would recommend that a trial of gonadotrophin releasing hormone analogues for at least 6 months particularly in cases of uterocutaneous fistula of 5 mm or less in diameter as this conservative treatment is likely to obviate the need for more hazardous surgical intervention.
The Virtue of Mortality
Authors: Flescher Andrew 
Published: November 2022

ABSTRACTAs technology's frontiers advance, we acquire the capacity to alleviate the aspects of suffering and sorrow that are caused by our genetic programming, while also inviting unwelcome side consequences. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats), a bacterial defense system with genome editing capabilities, is now being implemented to startling results. It is being used to correct for harmful mutations by permanently altering genes, promising to eliminate defects in whole species. Advantages notwithstanding, and apart from insufficiently considered dangers precipitated by the well‐intended technology, there are other moral issues to consider. What does existence look like in which humans become resistant to experiencing genetic defects? We can welcome medical innovation's reduction of undue hardship, but is there a threshold past which a permanently improved version of us makes us ineligible to participate in the human condition? This essay offers a theological and Aristotelian critique of using CRISPR for extensive human gene editing, arguing that it is our imperfections, including susceptibility to disease, decline due to aging, and the ephemerality of joy, which make us human.
A systematic review of dreams and nightmares recall in patients with rapid eye movement sleep behaviour disorder
Authors: Fasiello Elisabetta , Scarpelli Serena , Gorgoni Maurizio , Alfonsi Valentina , Galbiati Andrea , De Gennaro Luigi 
Published: November 2022

SummaryRapid eye movement (REM) sleep behaviour disorder is a REM sleep parasomnia characterised by the loss of the physiological muscle atonia during REM sleep, resulting in dream enactment behaviours that may cause injuries to patients or their bed partners. The nocturnal motor episodes seem to respond to the dream contents, which are often vivid and violent. These behavioural and oneiric features make the REM sleep behaviour disorder a potential model to study dreams. This review aims to unify the literature about dream recall in REM sleep behaviour disorder as a privileged approach to study dreams, systematically reviewing studies that applied retrospective and prospective experimental designs to provide a comprehensive overview of qualitative and quantitative aspects of dream recall in this REM sleep parasomnia. The present work highlights that the study of dreaming in REM sleep behaviour disorder is useful to understand unique aspects of this pathology and to explore neurobiological, electrophysiological, and cognitive mechanisms of REM sleep and dreaming.
Multiple arterial‐phase MRI with gadoxetic acid improves diagnosis of hepatocellular carcinoma ≤3.0 cm
Authors: Hong Seung Baek , Hong Sun , Choi Sang Hyun , Park Seo Young , Shim Ju Hyun , Kim So Yeon , Lee Seung Soo , Kim Suk 
Published: November 2022

AbstractBackground and AimsMultiple arterial‐phase magnetic resonance imaging (MA‐MRI) was introduced to overcome the limitations of gadoxetic acid‐enhanced MRI, but its clinical impacts on hepatocellular carcinoma (HCC) diagnosis have not been well assessed. We investigated whether MA‐MRI with gadoxetic acid could improve the diagnosis of HCC ≤3.0 cm in comparison with single arterial‐phase MRI (SA‐MRI).MethodsThis retrospective study included 397 patients from two tertiary institutions who underwent gadoxetic acid‐enhanced MRI (243 patients with 271 lesions in cohort‐1 underwent SA‐MRI, and 154 patients with 166 lesions in cohort‐2 underwent MA‐MRI). The patients had 437 hepatic lesions ≤3.0 cm with pathologic confirmation. The arterial‐phase image quality and diagnostic performance of SA‐MRI and MA‐MRI were analysed and compared. To minimize the effects of selection bias because of potential confounding between the two groups, propensity score‐matching was additionally performed.ResultsMA‐MRI showed a significantly higher percentage of optimal arterial‐phase timing (94.2% vs. 74.5%, p < .001) and lower incidence of inadequate examinations (1.3% vs. 5.8%, p = .034) than SA‐MRI. MA‐MRI had a significantly higher non‐rim arterial‐phase hyperenhancement (APHE) detection rate (94.9% vs. 85.5%, p = .005) and sensitivity for diagnosing HCC (87.4% vs. 70.0%, p < .001) than SA‐MRI, but no significant difference in specificity (92.9% vs. 93.1%, p = .966). In 123 pairs of propensity score‐matched patients, MA‐MRI had significantly higher sensitivity (89.1% vs. 74.5%, p = .006) than SA‐MRI with equal specificity (92.3% vs. 92.3%, p > .999).ConclusionsCompared with SA‐MRI, MA‐MRI with gadoxetic acid can detect more non‐rim APHE and significantly improve sensitivity for diagnosing HCC ≤3.0 cm, without a significant decrease in specificity.
Consistent desires and climate change
Authors: Coren Daniel 
Published: November 2022

AbstractPhilosophers have described the human perspective on climate change as a perfect moral storm. I take a new angle on that storm: I argue that our relevant desires feature a particularly problematic case of seemingly consistent but genuinely inconsistent desires. We have, first, non‐indexical desires such as a desire to (make the sacrifices necessary to) stop polluting our environment at some point. We have, second, indexical desires such as a desire not to (make the sacrifices necessary to) stop polluting our environment this year. Our indexical and non‐indexical desires are inconsistent. Such inconsistency is obvious in most short‐term, individual cases such as when we need to make a dentist appointment. But when it comes to climate change, that inconsistency is masked by factors such as longevity and bitter divisions. This is, unfortunately, why humanity may continue putting off the collective action required to address climate change.
Emerging adults’ judgments about helping at home: Situational and experiential sources of variability
Authors: Martinez Marie Grace S. , Dahl Audun 
Published: November 2022

AbstractJudgments and decisions about household helping affect how families function, and they develop through everyday experiences. Much prior research has examined stable individual differences in prosocial orientations, but such orientations also vary within individuals. The present work examined situational and experiential sources of variability in emerging adults’ judgments and reasoning about helping at home. The research assessed judgments and reasoning about household helping in events that were either hypothetical (Studies 1 and 2) or took place in participants’ own homes (Study 2). Participants’ judgments about helping incorporated moral, personal, and social‐conventional considerations and differentiated helping in one's own home from helping in another home. Participants’ past experiences with household helping predicted their judgments about helping. Findings supported the view that emerging adults’ judgments about household helping are informed by both situational considerations and personal experiences.
New insights intoCC2D2A-related Joubert syndrome
Authors: Harion Madeleine , Qebibo Leila , Riquet Audrey , Rougeot Christelle , Afenjar Alexandra , Garel Catherine , Louha Malek , Lacaze Emmanuelle , Audic-Gérard Frédérique , Barth Magali , Berquin Patrick , Bonneau Dominique , Bourdain Frédéric , Busa Tiffany , Colin Estelle , Cuisset Jean-Marie , Des Portes Vincent , Dorison Nathalie , Francannet Christine , Héron Bénédicte , Laroche Cécile , Lebrun Marine , Métreau Julia , Odent Sylvie , Pasquier Laurent , Trujillo Yaumara Perdomo , Perrin Laurine , Pinson Lucile , Rivier François , Sigaudy Sabine , Thauvin-Robinet Christel , Louvier Ulrike Walther , Labayle Olivier , Rodriguez Diana , Valence Stéphanie , Burglen Lydie 
Published: November 2022

PurposeIn this study, we describe the phenotype and genotype of the largest cohort of patients with Joubert syndrome (JS) carrying pathogenic variants on one of the most frequent causative genes,CC2D2A.MethodsWe selected 53 patients with pathogenic variants onCC2D2A, compiled and analysed their clinical, neuroimaging and genetic information and compared it to previous literature.ResultsDevelopmental delay (motor and language) was nearly constant but patients had normal intellectual efficiency in 74% of cases (20/27 patients) and 68% followed mainstream schooling despite learning difficulties. Epilepsy was found in only 13% of cases. Only three patients had kidney cysts, only three had genuine retinal dystrophy and no subject had liver fibrosis or polydactyly. Brain MRIs showed typical signs of JS with rare additional features. Genotype–phenotype correlation findings demonstrate a homozygous truncating variant p.Arg950* linked to a more severe phenotype.ConclusionThis study contradicts previous literature stating an association betweenCC2D2A-related JS and ventriculomegaly. Our study implies thatCC2D2A-related JS is linked to positive neurodevelopmental outcome and low rate of other organ defects except for homozygous pathogenic variant p.Arg950*. This information will help modulate patient follow-up and provide families with accurate genetic counselling.
Enhancing Human Pose Estimation in Ancient Vase Paintings via Perceptually-grounded Style Transfer Learning
Authors: Madhu Prathmesh , Villar-Corrales Angel , Kosti Ronak , Bendschus Torsten , Reinhardt Corinna , Bell Peter , Maier Andreas , Christlein Vincent 
Published: November 2022

Human pose estimation (HPE)
is a central part of understanding the visual narration and body movements of characters depicted in artwork collections, such as Greek vase paintings. Unfortunately, existing HPE methods do not generalise well across domains resulting in poorly recognised poses. Therefore, we propose a two step approach: (1) adapting a dataset of natural images of known person and pose annotations to the style of Greek vase paintings by means of image style-transfer. We introduce a perceptually-grounded style transfer training to enforce perceptual consistency. Then, we fine-tune the base model with this newly created dataset. We show that using style-transfer learning significantly improves the SOTA performance on unlabelled data by more than 6%
mean average precision (mAP)
as well as
mean average recall (mAR)
. (2) To improve the already strong results further, we created a small dataset (ClassArch) consisting of ancient Greek vase paintings from the 6–5th century BCE with person and pose annotations. We show that fine-tuning on this data with a style-transferred model improves the performance further. In a thorough ablation study, we give a targeted analysis of the influence of style intensities, revealing that the model learns generic domain styles. Additionally, we provide a pose-based image retrieval to demonstrate the effectiveness of our method. The code and pretrained models can be found at
https://github.com/angelvillar96/STLPose
.
Masoretic Accents and Phrasing in the Hebrew Bible Recitation: New Reflections
Authors: Kleiner Boris 
Published: November 2022

Abstract
The Masoretic Text is a codification of the recitation tradition, the crucial aspect of which is its phrasing represented by the masoretic accents. The accents address primarily the declamation rhythm rather than the pitch of the recitation melody. Disjunctive accents of different hierarchic prominence mark the phrasing caesurae as relatively major or minor, distinguishing between various grades of caesural depth. However, the chanted recitation realizes the caesurae by the positionally assigned durations that do not express the significance of the individual caesurae and are aligned only with the division of the text into superordinate phrases. Caesurae of different depth may be realized indiscriminately, yet are distinguished in the accentuation. By their differentiating notation the accentuators were able both to capture the phrasing sound of the oral tradition and to interpret, determine, and even manipulate its sense.
The Forecast Skill of Tropical Cyclone Genesis in Two Global Ensembles
Authors: Zhang Xiping , Fang Juan , Yu Zifeng 
Published: November 2022

Abstract
Tropical cyclone (TC) genesis forecasts during 2018–20 from two operational global ensemble prediction systems (EPSs) are evaluated over three basins in this study. The two ensembles are from the European Centre for Medium-Range Weather Forecasts (ECMWF-EPS) and the MetOffice in the United Kingdom (UKMO-EPS). The three basins include the northwest Pacific, northeast Pacific, and the North Atlantic. It is found that the ensemble members in each EPS show a good level of agreement in forecast skill, but their forecasts are complementary. Probability of detection (POD) can be doubled by taking all the member forecasts in the EPS into account. Even if an ensemble member does not make a hit forecast, it may predict the presence of cyclonic vortices. Statistically, a hit forecast has more nearby disturbance forecasts in the ensemble than a false alarm. Based on the above analysis, we grouped the nearby forecasts at each model initialization time to define ensemble genesis forecasts, and verified these forecasts to represent the performance of the ensemble system. The PODs are found to be more than twice that of the individual ensemble members at most lead times, which is about 59% and 38% at the 5-day lead time in UKMO-EPS and ECMWF-EPS, respectively; while the success ratios are smaller compared with that of the ensemble members. In addition, predictability differs in different basins, and genesis events in the North Atlantic basin are the most difficult to forecast in EPS, and its POD at the 5-day lead time is only 46% and 23% in UKMO-EPS and ECMWF-EPS, respectively.

Significance Statement
Operational forecasting of tropical cyclone (TC) genesis relies greatly on numerical models. Compared with deterministic forecasts, ensemble prediction systems (EPSs) can provide uncertainty information for forecasters. This study examined the predictability of TC genesis in two operational EPSs. We found that the forecasts of ensemble members complement each other, and the detection ratio of observed genesis will be doubled by considering the forecasts of all members, as multiple simulations conducted by the EPS partially reflect the inherent uncertainties of the genesis process. Successful forecasts are surrounded by more cyclonic vortices in the ensemble than false alarms, so the vortex information is used to group the nearby forecasts at each model initialization to define ensemble genesis forecasts when evaluating the ensemble performance. The results demonstrate that the global ensemble models can serve as a valuable reference for TC genesis forecasting.
Psychiatric service delivery for older people in hospital and residential aged care: An updated systematic review
Authors: Cations Monica , Wilton-Harding Bethany , Laver Kate E , Brodaty Henry , Low Lee-Fay , Collins Noel , Lie David , McKellar Duncan , Macfarlane Steve , Draper Brian 
Published: November 2022

Objective: To review studies reporting on the effectiveness of psychiatry service delivery for older people and people with dementia in hospital and residential aged care. Methods: A systematic search of four databases was conducted to obtain peer-reviewed literature reporting original research published since June 2004 evaluating a psychiatry service for older people (aged 60 years and over) or people with dementia in inpatient or residential aged care settings. Results: From the 38 included studies, there was consistent low-to-moderate quality evidence supporting the effectiveness of inpatient older persons’ mental health wards ( n = 14) on neuropsychiatric symptoms, mood, anxiety and quality of life. Inpatient consultation/liaison old age psychiatry services ( n = 9) were not associated with improved depression, quality of life or mortality in high-quality randomised studies. However, low-quality evidence demonstrated improved patient satisfaction with care and reduced carer stress. The highest quality studies demonstrated no effect of psychiatric in-reach services to residential aged care ( n  = 9) on neuropsychiatric symptoms but a significant reduction in depressive symptoms among people with dementia. There was low-quality evidence that long-stay intermediate care wards ( n = 6) were associated with reduced risk for dangerous behavioural incidents and reduced costs compared to residential aged care facilities. There was no effect of these units on neuropsychiatric symptoms or carer stress. Conclusions and implications: The scarcity of high-quality studies examining the effectiveness of old age psychiatry services leaves providers and policy-makers to rely on low-quality evidence when designing services. Future research should consider carefully which outcomes to include, given that staff skill and confidence, length of stay, recommendation uptake, patient- and family-reported experiences, and negative outcomes (i.e. injuries, property damage) are as important as clinical outcomes.
False discovery rate estimation using candidate peptides for each spectrum
Authors: Lee Sangjeong , Park Heejin , Kim Hyunwoo 
Published: November 2022

Abstract
Background
False discovery rate (FDR) estimation is very important in proteomics. The target-decoy strategy (TDS), which is often used for FDR estimation, estimates the FDR under the assumption that when spectra are identified incorrectly, the probabilities of the spectra matching the target or decoy peptides are identical. However, no spectra matching target or decoy peptide probabilities are identical. We propose cTDS (target-decoy strategy with candidate peptides) for accurate estimation of the FDR using the probability that the spectrum is identified incorrectly as a target or decoy peptide.

Results
Most spectrum cases result in a probability of having the spectrum identified incorrectly as a target or decoy peptide of close to 0.5, but only about 1.14–4.85% of the total spectra have an exact probability of 0.5. We used an entrapment sequence method to demonstrate the accuracy of cTDS. For fixed FDR thresholds (1–10%), the false match rate (FMR) in cTDS is closer than the FMR in TDS. We compared the number of peptide-spectrum matches (PSMs) obtained with TDS and cTDS at a 1% FDR threshold with the HEK293 dataset. In the first and third replications, the number of PSMs obtained with cTDS for the reverse, pseudo-reverse, shuffle, and de Bruijn databases exceeded those obtained with TDS (about 0.001–0.132%), with the pseudo-shuffle database containing less compared to TDS (about 0.05–0.126%). In the second replication, the number of PSMs obtained with cTDS for all databases exceeds that obtained with TDS (about 0.013–0.274%).

Conclusions
When spectra are actually identified incorrectly, most probabilities of the spectra matching a target or decoy peptide are not identical. Therefore, we propose cTDS, which estimates the FDR more accurately using the probability of the spectrum being identified incorrectly as a target or decoy peptide.
Phylogenomics, plastome degradation and mycoheterotrophy evolution of Neottieae (Orchidaceae), with emphasis on the systematic position and Loess Plateau-Changbai Mountains disjunction of Diplandrorchis
Authors: Peng Huan-Wen , Lian Lian , Zhang Jun , Erst Andrey S. , Wang Wei 
Published: November 2022

Abstract
Background
Mycoheterotrophy is a unique survival strategy adapted to dense forests and has attracted biologists’ attention for centuries. However, its evolutionary origin and related plastome degradation are poorly understood. The tribe Neottieae contains various nutrition types, i.e., autotrophy, mixotrophy, and mycoheterotrophy. Here, we present a comprehensive phylogenetic analysis of the tribe based on plastome and nuclear ITS data. We inferred the evolutionary shift of nutrition types, constructed the patterns of plastome degradation, and estimated divergence times and ancestral ranges. We also used an integration of molecular dating and ecological niche modeling methods to investigate the disjunction between the Loess Plateau and Changbai Mountains in Diplandrorchis, a mycoheterotrophic genus endemic to China that was included in a molecular phylogenetic study for the first time.

Results
Diplandrorchis was imbedded within Neottia and formed a clade with four mycoheterotrophic species. Autotrophy is the ancestral state in Neottieae, mixotrophy independently originated at least five times, and three shifts from mixotrophy to mycoheterotrophy independently occurred. The five mixotrophic lineages possess all plastid genes or lost partial/all ndh genes, whereas each of the three mycoheterotroph lineages has a highly reduced plastome: one lost part of its ndh genes and a few photosynthesis-related genes, and the other two lost almost all ndh, photosynthesis-related, rpo, and atp genes. These three mycoheterotrophic lineages originated at about 26.40 Ma, 25.84 Ma, and 9.22 Ma, respectively. Diplandrorchis had presumably a wide range in the Pliocene and migrated southward in the Pleistocene.

Conclusions
The Pleistocene climatic fluctuations and the resultant migration resulted in the Loess Plateau-Changbai Mountains disjunction of Diplandrorchis. In the evolution of mycoheterotrophic lineages, the loss of plastid-encoded genes and plastome degradation are staged and irreversible, constraining mycoheterotrophs to inhabit understories with low light levels. Accordingly, the rise of local forests might have promoted the origin of conditions in which mycoheterotrophy is advantageous.