bluuebunny/crossref_metadata_2025_split huggingface dataset:
Аgglutination test and passive hemagglutination test as immunological methods of antigenisisty assessment of vaccines against poultry salmonellosis
Authors: Boiko O. P. , Kurtyak B. М. , Sen' O. M. , Romanovych M. S. , Sobko G. V. , Pundyak T. O. , Boiko P. К. 
Published: May 2022

Salmonellosis ranks first among acute intestinal infections with an established pathogen in Ukraine. Poultry products are the most frequent source of human salmonellosis is the highest in both the world and Ukraine. Therefore, Salmonella-specific prevention measures in most countries are an issue of great importance. The study's goal was to compare the levels of antibodies against Salmonella to the enteritidis, Typhimurium, and infantis monoantigens in the serum of poultry immunized with the experimental bivalent, the trivalent vaccine against salmonellosis using the Agglutination test (AT) and Passive Hemagglutination test (PHA). The research of two Salmonella inactivated emulsified vaccines – bivalent (S. enteritidis) and trivalent (S. enteritidis, S. typhimurium and S. infantis) was conducted on one of the poultry farms of the Lviv region. The birds were vaccinated two times in the 14th day's interval. The sera samples were taken on the 14, 21, and 28th days after the last shot. The antibody (agglutinin) levels were assessed in the AT and PHA. Both vaccines (bivalent and trivalent) inducted an intense immune response in birds' organisms. The average antibody titers were 1 : 512 –1 : 717 using the AT and 1 : 4096 – 1 : 5734 using the PHA. The highest antibody levels were detected for S. Enteritidis: 1 : 5734 for trivalent vaccine and 1 : 5120 for bivalent one using PHA. AT antibody levels were lower: 1 : 717 for the trivalent vaccine and 1 : 640 for the bivalent. The antibody levels to S. typhimurium were: 1 : 4915 for trivalent vaccine and 1 : 4710 for bivalent (PHA) and 1 : 640 for trivalent vaccine 1 : 589 for bivalent on (AT). The lowest antibody levels were detected in S. Infantis in both tests. An interesting fact of S. infantis agglutinins presence in serum samples from poultry vaccinated with the bivalent vaccine in both tests may be explained by cross-immunity formed by S. enteritidis – S. typhimurium vaccine.
Improcedencia en la aplicación del Procedimiento Directo, en relación al sistema establecido en la normativa Penal Ecuatoriana.
Authors: Chávez-Castro José 
Published: May 2022

Resulta indudable que dentro del proceso penal versa la solución de conflictos, por consiguiente, se busca la eficacia de todos los procedimientos y la correcta aplicación de los principios y de los derechos fundamentales del individuo regidos dentro del ordenamiento jurídico. En efecto esta investigación pretende demostrar como la aplicación del procedimiento directo en aquellos delitos flagrantes vulnera derechos establecidos en la Carta Magna, como lo son el derecho a la defensa del procesado y a su vez el de ser juzgado con imparcialidad por los administradores de justicia, quienes necesariamente deben actuar acorde al sistema penal establecido en la normativa ecuatoriana.
Ahora bien, dentro del ámbito procesal penal se encuentran establecidos los llamados procedimientos especiales, entre ellos el establecido en el artículo 640 de nuestro Código Orgánico Integral Penal, en el que se establece la concentración de todas las etapas del proceso en una sola audiencia, esta a su vez se encuentra regulada por la misma normativa y en base a los principios que rigen al derecho penal, debido aquello es importante destacar la existencia de vulneraciones al derecho a la defensa, debido a que según lo señalado en el artículo que nos ocupa, el mismo juzgador que califica el delito como flagrante es el mismo juez de instrucción que deberá resolver la causa dictando sentencia, habiéndose ya contaminado de las actuaciones que dan origen al procedimiento, en consecuencia se está violentando el principio de imparcialidad, teniendo en cuenta además que con la entrada en vigencia del Código Orgánico Integral Penal el 10 de Agosto de 2014, en la normativa penal ecuatoriana rige el Sistema Adversarial, dejando a un lado la intervención del juez denominado inquisidor.
Vacinação em drogarias: aspectos legais e atuação do profissional farmacêutico
Authors: Silva Lucélia Maria Carneiro da , Melo Suely Moura , Araújo Jeorgio Leão 
Published: May 2022

O surgimento da vacina ocorreu após um surto de varíola que se iniciou na região da seda entre a China e Turquia. No Brasil em 1904 o Rio de Janeiro enfrentou uma epidemia de varíola que teve como resultado a Revolta da vacina. Os serviços de vacinação são ofertados nas Unidades Básicas de Saúde (UBS) na qual foi estendido também às farmácias e drogarias privadas por meio da Resolução do Conselho Federal de Farmácia n° 574 de 22 de maio de 2013. O objetivo do presente estudo foi descrever de que maneira as farmácias e drogarias podem desenvolver e aplicar o serviço de vacinação para a população. Trata-se de uma pesquisa descritiva de natureza qualitativa. Para a coleta de dados foi realizada pesquisas nas bases de dados do Science direct, Pubmed, Scielo por meio dos periódicos da CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), bem como a legislação do CFF (Conselho Federal de Farmácia) e ANVISA (Agência Nacional de Vigilância Sanitária). A Resolução n° 574 de 22 de maio de 2013 estabelece as atribuições e competências do farmacêutico, do qual umas das suas atribuições é a dispensação e aplicação de vacinas. Observou-se que as farmácias e drogarias que desejam ampliar seus serviços farmacêuticos por meio da vacinação precisam atentar para vários itens que são obrigatórios: licenciamento do órgão sanitário; estrutura física adequada para a demanda; insumos de qualidade e principalmente profissional farmacêutico habilitado para esse serviço, na qual é preciso comprovar mediante o CFF a qual pertence.
Um olhar para as novas diretrizes concernentes à formação docente
Authors: Schwartz Suzana , Vieira Mauricio Aires , Abrão Ruhena Kelber 
Published: May 2022

A qualidade da educação é influenciada por múltiplos fatores e diferentes autores apontam que a atuação didática do professor é a razão determinante da qualidade da aprendizagem dos alunos. Não é o único fator, mas é o mais importante. Sendo assim, políticas públicas voltadas para a qualificação da formação docente são necessárias, especialmente no caso do Brasil, que se encontra em uma situação difícil em relação aos indicadores de qualidade nos processos de ensino e de aprendizagem. As novas diretrizes para a formação veem na esteira desse cenário, a fim de induzir mudanças substanciais nos cursos de licenciatura. Metodologicamente, analisamos, a partir de uma abordagem qualitativa, o documento, ao pontuar alguns limitadores e sugerir possibilidades alternativas. Nosso objetivo foi o de refletir criticamente sobre o processo de (auto) formação docente promovido nos cursos de licenciatura no Brasil. Concluímos, por enquanto e considerando que muito precisa ser feito nos cursos de formação docente que as mudanças são dependentes/autônomas do contexto amplo no qual se inserem as instituições, os cursos, os componentes curriculares, os professores efetivos, os alunos e os servidores em geral. Para viabilizar mudanças significativas, todos esses agentes precisarão reconhecer a necessidade de mudar e assumir a tarefa como sua, atribuindo significado a ela. Isso é processo. Analisar e refletir criticamente sobre as novas diretrizes propostas pode contribuir nele.
Analisis Faktor Kepatuhan Obat ARV Saat Pandemi Covid-19 di Yayasan Cakap Peduli AIDS Turen
Authors: Sasono Tri Nurhudi 
Published: May 2022

HIV / AIDS is a disease caused by the Human Immunodeficiency Virus which lowers immunity by infecting and damaging the human immune system. Adherence to taking medication can increase the expectation and quality of life of PLWHA. The health condition of PLWHA is influenced by adherence to taking medication. The purpose of this study was to analyze the factors that influence medication adherence to people living with HIV / AIDS (PLWHA). The design of this research is analytic observational with aapproach cross sectional. The sample usedtechnique purposive sampling at NGO CAKAP AIDS Turen as many as 60 respondents. Retrieval of data using-based questionnaires. The statistical test is using multiple linear regression analysis. The results show that there is an influence of knowledge with a p-value of 0.017 <0.05 with a coefficient of 0.309, there is no influence on motivation with a p-value of 0.109> 0.05 with a coefficient of 0.107 and there is the effect of access to health services with a p-value of 0.012 <0.05 with a coefficient of 0.406. Based on these statistical results, it can be concluded that the factors that influence medication adherence are knowledge and access to health services.Keywords: Knowledge; Motivation and Access to Health Services; Compliance with Medication; HIV/AIDS
Kombinasi Pulse Oxymetri, Auskultasi, dan Dismorfik Feature untuk skrining Penyakit Jantung Bawaan Pada Bayi Baru Lahir di Malang
Authors: Koentarwi Dyahris , Oktaviana SC Linda , Azhar Nur Hidayati 
Published: May 2022

Latar Belakang. Pulse oksimetri (POX) banyak digunakan se­bagai deteksi PJB pada anak. Namun, akurasi pulse oxymetri sebagai pa­ra­meter tunggal kurang memuaskan. Oleh karena itu kombinasi peng­gunaan pulse oxymetri, auksultasi dan klinis dismorfisme fasial di­perkirakan dapat meningkatkan akurasi dan sensitivitas dalam deteksi PJB pada bayi baru lahir. Tujuan dari studi ini adalah untuk menilai sensitivitas, spesifisitas, nilai prediski positif, dan nilai prediksi negative dari kombinasi pulse oxymetri, auskultasi dan dismorfik feature.Metode. Studi potong lintang dilakukan di RSUD Dr Saiful Anwar Malang mulai Februari 2019 hingga Februari 2020. Pasien usia kurang dari 1 bulan yang dirujuk dari berbagai faskes di Malang Raya ke Departemen Anak RSUD Dr. Saiful Anwar Malang dengan curiga PJB. Subyek diukur saturasi oksigen, auksultasi, dan dismorfik feature kemudian dilakukan ekokardiografi untuk melihat adanya kelainan struktural jantung. Data diolah menggunakan Microsoft Excel dan dianalisa menggunakan software SPSS 22. Sensitivitas, spesifitas serta predictive value masing-masing dan kombinasi dihitung.Hasil. Subyek yang memenuhi kriteria penelitian ini berjumlah 274. Tiga belas subyek tidak didapatkan kelainan struktural jantung. Kelainan paling banyak ditemui adalah ASD diikuti dengan VSD. Empat puluh dua subyek memiliki saturasi kurang dari 90%. Murmur didapatkan pada 42 subyek. Dismorfik feature ditemukan pada 6 subyek. sensitivitas dan spesifiktas masing-masing parameter adalah 15,33% dan 84,64% untuk pulse oksimetri, 16,09% dan 100% untuk auskultasi, 2,3% dan 100% untuk dismorfik feature. Kombinasi ketiga metode meningkatkan sensitivitas menjadi 29,12% dan spesifitas menjadi 84,62% dengan PPV 97,44% LR+ sebesar 1,89.Kesimpulan. Penggunaan kombinasi pulse oxymetri, auskultasi dan dismorfik feature dapat meningkatkan sensitivitas diagnosis PJB pada bayi baru lahir di MalangKeywords: pulse oxymetri, auskultasi, dismorfik feature, penyakit jantung bawaan
Psoriasis Relationship with Hypertension in Psoriasis Patients at RSI Jemursari Surabaya
Authors: Gumilang Retna , Sinantryana Widyaswari Meidyta , Rizkiyyah Husin Zakiyyatur 
Published: May 2022

Abstract. Background: Psoriasis is a chronic inflammatory disease of the skin that characterized by firmly bound erythema plaques covered in thick squama and caused by multiple abnormalities of genetic, biochemical, immunologic, vascular with further severed by various other factors such as psychology, drugs, smoking, and alcohol consumption. Several studies revealed that psoriasis can increase the risk of cardiovascular diseases such as hypertension, however, the underlying pathophysiological mechanism has not been confirmed yet. This mechanism is probably attributed to increased levels of angiotensin-converting enzyme produce angiotensin II that regulates vascular tonus, endothelin-1 (ET-1) has been considered an important role in that vasoconstrictor proteins are potent, and increased plasma renin activity has been reported in patients with psoriasis. Purpose: In order to figure out the relationship between psoriasis and hypertension in psoriasis patients at the Outpatient Unit -RSI Jemursari Surabaya. Methods: This study was observational analytics with cross sectional study design in 28 psoriasis patients at Outpatient Unit-RSI Jemursari Surabaya during 2017-2019, using total sampling technique. Secondary data from medical records was collected and further analyzed with spearman correlation tests. Result: The obtained significance value is 0.000 (p < 0.05), which represent a significant relationship between hypertension and psoriasis. the correlation coefficient is 0.757, which indicates the strength of a strong relationship between two variables. Conclusion: There is a significant association between Psoriasis and Hypertension.
Komplikasi Nyeri dan Perdarahan Pasca Sirkumsisi Metode Klem
Authors: Budi Deskianditya Resa , Kusumawati Anis , Handoyo Sakti Yuhantoro Budi , Faisa Adiyanti Naura , Diva Wulandari Sabrina 
Published: May 2022

Abstract: Circumcision is a minor surgery procedure that provides several benefits and is closely related to religious life. Currently there are various methods in the action of circumcision. The incindence of complication related to circumcision is low, but various variations of methods can affect complications. The aim of this study is to present data on the incidence of pain and bleeding complication post clam method circumcision, as well as the factors associatd with both complications. This study is an observa­tional analytic study with a cross-sectional method, with the research subject is medical record data at Klinik Rumah Sunatan Purwokerto for the period January 2017 – August 2020 which meets the inclusion criteria and excluded from exclusion criteria. Data were collected and performed bivariate analysis of independent variables to complications of pain and bleeding using the Spearmen method for numerical variables and Chi square for nominal and ordinal variables, and follow up with the backward logisitic regression test. There were 153 medical record data met the criteria, with 47.7 % pain complication and 38.6 % bleeding compllication. Multivariate test showed a significant relationship between aged and pain (p = 0.039; B = -0.155) and bleeding complication (p = 0.003; B = -0.202), glans adhesions with pain (p = 0.007; B = 1.295) dan bleeding complication (p = 0.005; B = 1.346), and narrow prepucium and pain (p = 0.002; B = 1.294) and bleeding complication (p = 0.003; B = 1.200). The conclusion of this study is the frequency of pain and bleeding complication were 47,7 % and 38,6 % respectively, and there was a significat relationship between age, glans adhesions, and narrow prepucium with pain and bleeding compli­cations.
Pregnancy and Perinatal Outcomes of Patients With Prior Cesarean Section After a Single Embryo Transfer in IVF/ICSI: A Retrospective Cohort Study
Authors: Wang Lin , Wang Jing , Lu Nan , Liu Jiayin , Diao Feiyang 
Published: May 2022

ObjectiveTo study the influence of the previous cesarean section on the pregnancy outcomes and perinatal outcomes in single embryo transfer (SET) cycles in an in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) setting compared to those with previous vaginal delivery (VD). In addition, the association between fertility outcomes and different cesarean scar defect (CSD) sizes was studied.MethodThis was a retrospective cohort study conducted in the Reproductive Center of the First Affiliated Hospital of Nanjing Medical University. A total of 4,879 patients with previous delivery history undergoing SET were included between January 2015 and April 2019. Patients were divided into the VD group and cesarean delivery (CD) group according to different modes of previous delivery. The primary outcome was live birth rate. The pregnancy outcomes of CD were analyzed as a subgroup and the relationship between pregnancy outcomes as well as the different sizes of CSD were explored by logistic regression analysis.ResultsThere were no significant differences in live birth rate, clinical pregnancy rate, and miscarriage rate between the CD group and VD group. The incidence rates of pregnancy complications such as pregnancy hypertension, gestational diabetes mellitus, placenta abnormalities, premature rupture of membrane, and postpartum hemorrhage were similar in the two groups. Live birth rate was significantly lower in the CSD group (23.77% vs 37.01%, aOR: 0.609, 95% CI: 0.476-0.778) comparing to patients without CSD. There were also significant differences in clinical pregnancy rate (37.52% vs 47.64%, aOR: 0.779, 95%CI: 0.623-0.973) and miscarriage rate (34.55% vs 20.59%, aOR: 1.407, 95%CI:1.03-1.923). Large size CSD significantly decreased live birth rate (13.33% vs 26.29%, aOR: 0.422, 95%CI: 0.197-0.902) and clinical pregnancy rate (25.33% vs 40.09%, aOR: 0.503, 95%CI: 0.272-0.930) compared with small size CSD.ConclusionFor women with previous cesarean sections, the pregnancy outcomes were similar to those with previous VD without increased perinatal complications following SET. The presence of CSD was associated with a marked reduction in live birth rate, especially in patients with large size CSD.
Making Every Step Count: Minute-by-Minute Characterization of Step Counts Augments Remote Activity Monitoring in People With Multiple Sclerosis
Authors: Block Valerie J. , Waliman Matthew , Xie Zhendong , Akula Amit , Bove Riley , Pletcher Mark J. , Marcus Gregory M. , Olgin Jeffrey E. , Cree Bruce A. C. , Gelfand Jeffrey M. , Henry Roland G. 
Published: May 2022

BackgroundAmbulatory disability is common in people with multiple sclerosis (MS). Remote monitoring using average daily step count (STEPS) can assess physical activity (activity) and disability in MS. STEPS correlates with conventional metrics such as the expanded disability status scale (Expanded Disability Status Scale; EDSS), Timed-25 Foot walk (T25FW) and timed up and go (TUG). However, while STEPS as a summative measure characterizes the number of steps taken over a day, it does not reflect variability and intensity of activity.ObjectivesNovel analytical methods were developed to describe how individuals spends time in various activity levels (e.g., continuous low versus short bouts of high) and the proportion of time spent at each activity level.Methods94 people with MS spanning the range of ambulatory impairment (unaffected to requiring bilateral assistance) were recruited into FITriMS study and asked to wear a Fitbit continuously for 1-year. Parametric distributions were fit to minute-by-minute step data. Adjusted R2 values for regressions between distributional fit parameters and STEPS with EDSS, TUG, T25FW and the patient-reported 12-item MS Walking scale (MSWS-12) were calculated over the first 4-weeks, adjusting for sex, age and disease duration.ResultsDistributional fits determined that the best statistically-valid model across all subjects was a 3-compartment Gaussian Mixture Model (GMM) that characterizes the step behavior within 3 levels of activity: high, moderate and low. The correlation of GMM parameters for baseline step count measures with clinical assessments was improved when compared with STEPS (adjusted R2 values GMM vs. STEPS: TUG: 0.536 vs. 0.419, T25FW: 0.489 vs. 0.402, MSWS-12: 0.383 vs. 0.378, EDSS: 0.557 vs. 0.465). The GMM correlated more strongly (Kruskal-Wallis: p = 0.0001) than STEPS and gave further information not included in STEPS.ConclusionsIndividuals' step distributions follow a 3-compartment GMM that better correlates with clinic-based performance measures compared with STEPS. These data support the existence of high-moderate-low levels of activity. GMM provides an interpretable framework to better understand the association between different levels of activity and clinical metrics and allows further analysis of walking behavior that takes step distribution and proportion of time at three levels of intensity into account.
Discriminative Monitoring of Seamless Rail Force by a High-Birefringence Effect-Based Fiber Optic Sensing Method
Authors: Zhou Yin , Yan Lianshan , Wang Ping , Chen Rong , Li Zonglei , Ye Jia , Pan Wei , Luo Bin 
Published: May 2022

Nowadays, China has developed over 38,000-km high-speed railways (HSR). As one of the key elements in the HSR system, continuous welded rail (CWR) enables higher transportation efficiency, while demands for more robust inspection and maintenance techniques. The discrimination between longitudinal temperature force and longitudinal additional force is one of the main challenges in the rail health status evaluations. In this paper, the high-birefringence fiber Bragg grating (HB-FBG) is applied to reach the rail force discriminative measurement. By inscribing the Bragg grating on a high-birefringence fiber, two kinds of sensing modes can be generated and adopted to realize the discriminative measurement of longitudinal temperature force and longitudinal additional force. In the verification experiments, the longitudinal temperature and additional force are accurately measured with the error less than 1 kN. The accurate-measurement and easy-manufacture of the HB-fiber and HB-FBG make it possible to connect massive sensors in series to reach long-range monitoring of the rails on the land or cross-sea bridges.
Sex Modulates Cardiovascular Effects of Icodextrin-Based Peritoneal Dialysis Solutions
Authors: Paniagua Ramón , García-López Elvia , Ávila-Díaz Marcela , Ventura María-de-Jesús , Orihuela Oscar , Prado-Uribe María-del-Carmen , Gallardo-Montoya Juan-Manuel , Lindholm Bengt 
Published: May 2022

Background/Aims: Some previous observations have noted that after six months of peritoneal dialysis (PD) treatment with icodextrin solutions, blood pressure (BP) and NT-proBNP tend to return to baseline values. This may be due to accumulation of icodextrin products that exert a colloid osmotic effect, which drives water into the bloodstream, causing the rise in blood pressure. Since icodextrin is metabolized by α-Amylase and its gene copies are lower in females than in males, we hypothesized icodextrin metabolites reach higher concentrations in females and that cardiovascular effects of icodextrin are influenced by sex.Methods: Secondary analysis of a RCT comparing factors influencing fluid balance control in diabetic PD patients with high or high average peritoneal transport receiving icodextrin (n = 30) or glucose (n = 29) PD solutions. Serum icodextrin metabolites, osmolality, body composition and Inferior Vena Cava (IVC) diameter were measured at baseline, and at 6 and 12 months of follow-up.Results: After six months of treatment, icodextrin metabolites showed higher levels in females than in males, particularly G5-7 and &gt;G7, serum osmolality was lower in females. In spite of reduction in total and extracellular body water, ultrafiltration (UF) was lower and IVC diameter and BP increased in females, suggesting increment of blood volume.Conclusion: Females undergoing PD present with higher levels of icodextrin metabolites in serum that may exert an increased colloid-osmotic pressure followed by less UF volumes and increment in blood volume and blood pressure. Whether this could be due to the lesser number of α-Amylase gene copies described in diabetic females deserves further investigation.