bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of hemoglobin level at admission with postoperative pneumonia in elderly patients with hip fracture: a retrospective cohort study
Authors: Zhang Daxue , Zhang Yu , Yang Shiwei , Zhang Ning , Sun Lixin 
Published: December 2022

Abstract

Background and Aim

Postoperative pneumonia (POP) is a common complication in elderly patients with hip fracture. Low preoperative hemoglobin (Hb) levels have shown strong associations with POP including, but the cut-off value of Hb level remains to be elusive. In this study, we investigated the quantitative relationship between preoperative Hb levels and the accidence of POP in elderly patients with hip fracture.

Methods

This study was a retrospective cohort study. A total of 1444 elderly patients with hip fracture admitted to the Department of Orthopedics, Shenzhen Second People's Hospital from January 2012 to December 2021 were retrospectively included. Demographic and clinical data (including laboratory tests) were analyzed and compared to explore the relationship between Hb level at admission and POP.

Results

There were 389 males and 1055 females with an average age of 77.55 ± 8.75 years. The incidence of POP in elderly patients with hip fracture was 6.30% (91/1444). The regression equation showed that, without adjustment for covariates, the incidence of POP decreased by 52% (P = 0.0136) and 59% (P = 0.0047) in Q3 and Q4 in comparison to Q1, respectively. After adjusting for confounding factors, a nonlinear relationship was achieved between Hb and pneumonia. Threshold effect analysis showed that the inflection point was 82.3 g/L. On the left side of the inflection point, Hb level was negatively correlated with the incidence of POP (OR: 0.90, 95%CI: 0.84–0.96, P = 0.00178). On the right side of the inflection point, there was no correlation between Hb levels and POP (OR: 1.00, 95%CI: 0.98–1.01, P = 0.7938).

Conclusion

There is a nonlinear relationship between preoperative Hb level and POP in elderly patients with hip fracture. When the Hb level was lower than 82.3 g/L, the preoperative Hb level was negatively correlated with POP, but when the Hb level was higher than 82.3 g/L, no correlation was observed.
Inverted Internal Limiting Membrane Flap VS. ILM Peeling for ＜400μm Macular Hole: a meta-analysis and systematic review
Authors: Li Pingping , Li Lu , Wu Jianhua 
Published: December 2022

Abstract
Inverted internal limiting membrane (ILM) flap technique was developed to achieve macular hole (MH) closure in large MH. But the efficacy of small holes has been controversial. The aim of this study was to compare the anatomical and visual outcomes of vitrectomy (PPV) combined with the inverted ILM flap and ILM peeling in small and medium size MHs. Search relevant literature within PubMed, Web of Science, Embase, Cochrane library, and CNKI from inception through October 2022 in English or Chinese. Only case-control studies were included. Heterogeneity, publication bias, and sensitivity analysis were conducted to ensure the statistical power. This meta-analysis included six studies involving 299 eyes, 3 randomized control trials, and 3 retrospective studies. Summarizing data displayed that the MH closure rate was not different between the inverted ILM flap group and peeling group (odds ratio(OR) = 0.29, 95% confidence interval (CI): 0.04 ~ 1.96, P = 0.33 ). Whereas there was no significant difference in visual acuity improvement, the integrity of the external limiting membrane (ELM) and the ellipsoid zone (EZ) in 3 months or 12 months after surgery between the two groups. Therefore inverted ILM flap and ILM peeling are both effective treatments for＜400μm MHs, and are associated with comparable outcomes as well as don't damage the integrity of the retina.
A Variant Mutation in the gene encoding Mitochondrial Seryl-tRNA Synthetase Cause HUPRA Syndrome with Atypical Presentation-A Case Report
Authors: Lahham Elias Edward , jamal Juhina , Adawi Du’a Osamah , Ismail mohamad Khaled 
Published: December 2022

Abstract
Background
Hyperuricemia, pulmonary hypertension, renal failure, and alkaline intoxication syndrome (HUPRA syndrome) is a rare autosomal recessive mitochondrial disease with prevalence of less than one in a million. Due to mutations in the mitochondrial SARS enzyme encoding seryl-tRNA synthetase on chromosome 19 (19q13.2).
Case–Diagnosis/Treatment
We investigated two Palestinian girls from the same village presented with progressive renal failure in infancy were diagnosed with this multisystemic disease. presented with atypical clinical manifestations of HUPRA syndrome include leukopenia, anemia, salt wasting resulting in hyponatremia and hypochloremia, renal failure with elevated blood lactate, marked hyperuricemia, hypercholesterolemia and hypertriglyceridemia but without pulmonary hypertension or alkaline intoxication that distinguish them from the rest of the usual cases, instead they showed acidosis in routine follow up. By using single exome sequencing analysis, we identified a two homozygous pathogenic mutation c.1175A>G (p.D392G), c.1169A>G (D390G) in SARS2 gene. This sequence identified a new variant mutation of HUPRA syndrome c.1175A>G (p.D392G) with atypical presentation, that will be added to the literature.
Conclusion
SARS2 gene with pathogenic homozygous mutation variants were detected in our two patients c.1175A>G (p.D392G), c.1169A>G (D390G) in exon 13, with atypical clinical manifestations of HUPRA syndrome, expanding the spectrum of SARS2 pathogenic variants with its characteristic findings, describing the differences in clinical manifestations between homozygous and compound heterozygous mutations.
Outburst floods strongly influence valley evolution in the Tsangpo Gorge, Eastern Himalaya
Authors: Dong Xiaolu , Wang Xianyan , Yang Long , Zhao Zhijun , Balen Ronald van , Miao Xiaodong , Liu Tao , Vandenberghe Jef , Pan Baotian , Gibling Martin , Lu Huayu 
Published: December 2022

Abstract
Regular flows and infrequent outburst floods shape many mountain landscapes, but the relative contributions from these gradual processes and infrequent high-magnitude events have been widely debated, in part due to a paucity of reliable data from historical outburst floods. Here we quantify erosion and deposition from a catastrophic outburst flood in June 2000, caused by a landslide-dam failure on the Yigong River in a rapidly exhumed region of the Eastern Himalaya. The flood, with a peak discharge of 105 m3/s, lasted for only ~ 10 hours, but its geomorphic effects were equivalent to the cumulative effect of 1–2×103 years of long-term fluvial processes in the region. Ubiquitous boulder bars deposited in the channel by the flood promoted extensive lateral erosion through increased bed roughness. As a result, the valley floor widened threefold, triggering many additional secondary landslides, which contributed boulders to the riverbed. The resultant widespread bank erosion and concurrent landslides will continue to influence fluvial dynamics until the next catastrophic flood remobilizes the boulders. Our quantitative findings highlight the importance of recurrent outburst floods for gorge development and landscape evolution in southern Asia and in rapidly uplifting mountain belts worldwide. Teaser Infrequent outburst floods from short-lived natural dams strongly impact fluvial and hillslope processes in rapidly uplifting mountain belts, and they are a major process of incision and gorge formation in river valleys.
Transcriptome analysis of hepatic fibrosis induced by common bile duct ligation
Authors: Ren Junjie , Zhang Chunhong , Lv Tingting , Kong Yangyang , Huang Tingjuan 
Published: December 2022

Abstract
Cholestatic is an important factor causing liver fibrosis with a clinical incidence rate of about 10.26%. Although the progress of cholestatic hepatic fibrosis can be delayed by clearing the etiology and improving bile toxicity, how to treat antifibrotic is still an important and difficult problem in clinical treatment. In this study, we utilized Illumina sequencing technology to deeply mine the changes of mRNA expression during BDL-induced hepatic fibrosis. A total of 239,727,428 clean reads and 3224 Differentially expressed genes (DEGs) were obtained with 2852 genes were upregulated and 372 genes were downregulated. GO enrichment revealed that DEGs were mostly associated with biological processes, among which cellular process is the most enriched with 2253 genes up-regulated and 270 genes down-regulated. KEGG annotated 340 pathways in all, of which pathways in cancer and PI3K-Akt signaling pathway were most enriched. Six significantly DEGs were verified by RT-qPCR, and the results were consistent with the transcriptome sequencing outcome. These DEGs and pathways may play a crucial role in the occurrence and development of liver fibrosis, and may be potential therapeutic targets of liver fibrosis. Further investigations are needed to clarify its specific mechanism.
Salivary Proteomic Patterns in Children Affected by Different Severity Degrees of Molar Incisor Hypomineralization
Authors: Toledo¹ Elora Silva , Rizzardi¹ Karina Ferreira , de Carvalho Fabíola Galbiatti , Nobre-dos-Santos Marinês , Sciani Juliana Mozer , Parisotto Thaís Manzano 
Published: December 2022

Abstract
Saliva is a rich-bodily fluid with recognized clinical diagnosis roles and this research aimed at investigating if there is any change in the salivary proteome signatures of MIH children with distinct degrees of severity. Fifty schoolers (6–10 years) were equally assigned into the following groups: G1 (Control group - Healthy teeth), G2 (Mild MIH with white/creamy opacity and free of caries), G3 (Mild MIH with yellow/brown opacity and free of caries), G4 (Severe MIH with white/creamy, yellow/brown opacities including post-eruptive fracture and free of caries), G5 (Severe MIH with white/creamy, yellow/brown opacities, post-eruptive fracture, and caries). Unstimulated saliva samples were collected and later explored using mass spectrometry analysis. In total, 6,471 proteins were found, 5,073 exclusively from MIH children, and 778 overlapping among the different degrees of the disturb. The Biological Pathways displayed distinct patterns among the groups, being different according to the degrees of MIH. Gene-Odontology differences might not be verified regarding the biological processes and cellular components. Conversely, with respect to molecular function, alterations among groups were evident, with the presence of proteins that would contribute to MIH in children with the severe condition (i.e, calcium ion binding, microtubule binding, platelet-derived growth factor binding). In conclusion, the results of this study support important salivary proteomic changes in MIH children, according to distinct degrees of severity, reinforcing the interplay between the clinical characteristics and changes in the salivary proteome.
Characterisation of patients with paediatric dyssynergia, a single centre experience
Authors: Dokal Kitt , Bingham Carly , White Emily , Mutalib Mohamed 
Published: December 2022

Abstract
Purpose: Dyssynergic defecation is a common functional defecation disorder in children with four known types. Compared to adults, paediatric dyssynergic defecation is not as well characterised. We sought to better define patients with Type I and II paediatric dyssynergia as this may facilitate future management strategies.
Methods: The demographic profile, detailed medical history and treatments were obtained from 26 patients diagnosed with Type I and II dyssynergic defecation at the Evelina London Children’s Hospital from April 2019 to November 2021.
Results: Twenty patients were diagnosed with Type I dyssynergia (average age 9.9 years, standard deviation (SD) of 2.6). Six patients were diagnosed with Type II dyssynergia (average age 10.8 years, SD of 3.7). The major subset of the patient cohort had significant gastrointestinal symptoms including 20 (77%) experiencing soiling and 19 (73%) displaying withholding. Many patients had a number of comorbidities (including respiratory, neurological and genitourinary). There were also notable psychological, social and developmental conditions (73%) including anxiety, autism and cerebral palsy. 22 patients were taking at least one laxative as treatment. 21 of the 26 patients required disimpaction treatment. None of these patients required surgical intervention.
Conclusions: Our results show that a high proportion of patients with dyssynergic defecation have significant psychosocial conditions. This may contribute to the development and progression of this condition by shaping the cognitive schemas which lead to voluntary withholding. Management of these patients should therefore include a comprehensive psychosocial assessment in addition to managing the symptoms of defective defecation.
Correlation between nasal obstruction, quality of life and costs of endoscopic vs. microscopic transsphenoidal pituitary surgery in a low/middle-income country
Authors: Peñaranda Augusto , Jimenez-Hakim Enrique , Pérez-Herrera Lucia C. , Peñaranda Daniel , Moreno-López Sergio , Hakim Fernando , Garzón Juan , Pinzón-Navarro Martín 
Published: December 2022

Abstract
Few studies compare the post-operative nasal symptoms, quality of life, and costs in the microscopic vs. endoscopic transsphenoidal approaches for pituitary adenomas, particularly in low/middle-income Latin American populations. This ambispective study correlated the perception of nasal obstruction, quality of life and costs of endoscopic vs. microscopic transsphenoidal pituitary surgery at the Fundación Santa Fe de Bogotá, Colombia between January 2018, and December 2019. A total of 46 patients (mean age: 50.57 years) who underwent pituitary resection for adenomas either by microscopic or endoscopic approach in the Neurosurgery and/or Otolaryngology departments of the Fundación Santa Fe de Bogotá were included. Postoperative perception of nasal obstruction was assessed through the Nasal Obstruction Symptom Evaluation (NOSE) and a visual analog scale (VAS). Quality of life was assessed with the Glasgow Benefit Inventory (GBI). Surgical-related and hospitalization costs were extracted from the hospital’s finances database. A median difference of 45 points favoring the microscopic approach was found in the global scores of the NOSE scale. A median difference of 4 points was found in the VAS score (p<0.001 in both interventions). The GBI median scores were 27.78 points (IQR: 55.56), and 25.00 (IQR: 25) for the microscopic and endoscopic approaches, respectively. A negative correlation between the GBI and NOSE was found (ρ̂=-0.44; 95% CI: -0.684 to -0.095), implying that the less postoperative nasal obstruction, the better quality of life. The difference between median surgical-related costs was $ 437.92 USD, favoring of the microscopic approach (p=0.03). Nasal obstruction and quality of life were correlated, highlighting the impact of sinonasal outcomes in patients’ quality of life. Statistically significant differences were found in postoperative nasal obstruction symptoms and costs, favoring the microscopic approach.
Mediating role of pain self-efficacy in the relationship between sense of coherence, spiritual well-being and self-compassion with quality of life in iranian elderly with cardiovascular disease
Authors: Salehi Nahid , Afrashteh Majid Yousefi , Majzoobi Mohammad Reza , Ziapour Arash , Janjani Parisa , Karami Sahar 
Published: December 2022

Abstract
Background: Population ageing is considered one of the biggest challenges facing the world, and the status of the elderly in society and their quality of life (QOL) have proved to be a concern in professional and scientific research circles. As a result, the current study sought to investigate the role of pain self-efficacy (PSE) as a moderator in the relationship between sense of coherence (SOC), spiritual well-being, and self-compassion with QOL in Iranian elderly with cardiovascular disease (CVD).
Method: This was a correlational study of the path analysis type. The statistical population included all elderly people with CVD who were at least 60 years of age in Kermanshah Province, Iran, in 2022, of whom 298 (181 men and 117 women) were selected using convenience sampling and according to the inclusion and exclusion criteria. The participants answered questionnaires from the World Health Organization on QOL, Paloutzian and Ellison’s spiritual well-being, Nicholas’s PSE, Antonovsky’s SOC, and Raes et al.’s self-compassion.
Results: The results of path analysis demonstrated that the hypothesised model of this study has a good fit in the studied sample. In this way, SOC, spiritual well-being, and self-compassion had a significant relationship with QOL through PSE.
Conclusion: These results emphasise the importance of the role of PSE in increasing the quality of life of the elderly with CVD.
Predication of deterioration components of reinforced concrete columns using machine learning methods
Authors: Khoshkroodi Azadeh , Sani Hossein Parvini , Aajami Mojtaba 
Published: December 2022

Abstract
Deterioration components (DCs) of reinforced columns (RC) are important for predication the seismic behavior and performance of RC structures. Theses DCs parameters include: Plastic chord rotation from yield to cap (θp), post capping plastic rotation capacity from the cap to point of zero strength (θpc) and normalized energy dissipation capacity relation between deterioration components of RC columns with different properties(λ). This paper investigates several machine learning (ML) algorithms for the prediction of DCs, referred to as ML-DCs, based on the results of 255 experimental reinforced concrete columns tests conducted from 1973 to 2002. The performance of the models are considered using regression metrics. In this regard, machine learning algorithms such as Least Squares Support Vector Machine (Lssvm), AdaBoost, Artificial Neural Network (ANN), Random Forest (RF), Support Vector Regression (SVR) and XGBoost are applied and finally the results obtained from the models are compared with experimental relationships. The XGBoost algorithm provides enhanced accuracy of 95% for θp, 84% for θpc, and 93% for λ comparing to the others. Also, the results of machine learning algorithms indicate that the results obtained from the machine learning models are more effective than the empirical relationships achieved by the test results.
The role of chondrocyte-to-osteoblast trans-differentiation in fetal bone dysplasia of mice caused by prenatal exposure to dexamethasone
Authors: Zhu Jiayong , Zhao Xiaoqi , Wang Hui , Xiao Hao , Chen Liaobin 
Published: December 2022

Abstract
Maternal exposure to dexamethasone can cause developmental toxicity of long bones in offspring. However, the effect of dexamethasone on the trans-differentiation of growth plate chondrocytes into osteoblasts and its role in bone dysplasia of fetuses caused by prenatal dexamethasone exposure (PDE) remains unclear. In this study, pregnant mice were treated with different doses, stages, and courses of dexamethasone according to clinical practice to reveal the phenomenon. Further, growth plate chondrocytes were treated with dexamethasone in vitro to clarify the phenomenon and mechanism. The results showed that PDE caused dysplasia of fetal long bones in female and male mice, accompanied by the delayed formation of the primary ossification center and the widening hypertrophic zone of growth plate cartilage. Meanwhile, PDE increased the number of hypertrophic chondrocytes at growth plate cartilage and decreased the number of osteoblasts at the primary ossification center. Moreover, PDE significantly decreased the expression of osteogenic transcription factor Runx2 but increased the expression of hypertrophic chondrocytes marker Col10. These above phenomena were more significant in the high dose, early stage, and double courses of dexamethasone exposure groups, and the male fetal mice showed more obvious than the female fetal mice. In vitro, dexamethasone significantly inhibited the trans-differentiation of growth plate chondrocytes into osteoblasts, accompanied by a decrease in Runx2 expression and an increase in Col10 expression. In conclusion, this study revealed the phenomenon and mechanism of fetal bone dysplasia caused by PDE from the new perspective of trans-differentiation disorder of growth plate chondrocytes to osteoblasts.
Extended Producer Responsibility and Enforcement of Single-Use Plastic Ban in Pune City of India
Authors: Nomani M. Z.M. , Al-Farhad M. M. , Mustafa Faizan 
Published: December 2022

Abstract
India has experienced tremendous production, use, and discarding of plastic waste. The municipal and solid wastes proliferation of municipal waste, especially plastic waste, paved the way for the regulatory framework to implement the plastic ban in 18 states and Union Territories of India. In contrast, they have implemented a partial ban on plastic bags respectively. It addressed the phasing out of multi-layered plastics (MLP) and incorporated Extended Producer Responsibility (EPR) within the circular economy of plastic waste generation and recycling. It is generally believed that the plastic ban in India has feeble administrative support and effective implementation. Therefore, the government has passed the Draft Plastic Rules, 2009; Plastic Waste (Management and Handling) Rules, 2011; Plastic Waste Management Rules, 2016 and Draft Plastic Waste Management Rules, 2021. It made vital changes in recycled plastic manufacture and usage at national and state levels. Since the net outcome of the failure is environmental degradation beyond reparable limits, the most vociferous articulation of the banning of the single-use came through the Notification on Plastic and Thermocol Products, 2018 by the Government of Maharashtra. Although the new legal framework carried high deterrent value, the implementation has been heavily flawed. The paper deals with the plastic laws and performance in the context of EPR in Pune city of India. It suggests viable recommendations and strategies from a multi-stakeholder perspective.
Evaluation of artificial diets for rearing Spodoptera frugiperda (Smith) (Lep: Noctuidae) intended biocontrollers search
Authors: Bedoya Johanna Andrea Obando , Arbelaez Julian Andres Valencia 
Published: December 2022

Abstract
To develop a methodology for laboratory rearing of S. frugiperda for the production of bio-controllers, which allow biological control of this important pest. Four artificial diets were evaluated, two of them with grain flour (bean and chickpea) and agar; two prepared with cassava and lentil starch.
Methodology: The tests were carried out in three consecutive generations; in the first one the efficiency of the diets with agar was estimated, and in the second one diets without agar and the best diet of the first trial. A final test included all artificial diets. Larval size, pupal weight and length, adult longevity and fertility, and duration of each developmental stage were determined.
Results: Larval development in bean and wheat germ had no significant differences (p>0.05) (L1=2.57 mm; L2=5.83 mm; L3=9.95 mm; L4=14.7 mm; L5=21.4 mm; L6=28.01 mm and L1=2.55; L2=5.79; L3=10.16; L4=14.62 and L6=27.56 mm respectively) with the reference diet. Pupae weights ranged from 0.21g to 0.18g. The average weights in each of the cases were, 0.18 g, 0.19g, and 0.16g approximately for the diets containing bean, wheat germ, and chickpea respectively; and showed significant differences (p>0.05) with the control (0.21g.).
Conclusion: The bean diet did not show significant differences (p>0.05) with the control for the insect development time (53, 39 days, 48.53 days, and 43.61 days for the artificial diet and 36.37 days, 38.42 days and 41.56 days for the reference diet).