bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined kinetic analysis of SARS-CoV-2 RNAemia, N-antigenemia and virus-specific antibodies in critically ill adult COVID-19 patients
Authors: Costa Rosa , Alberola Juan , Olea Beatriz , Gozalbo-Rovira Roberto , Giménez Estela , Cuevas-Ferrando Enric , Torres Ignacio , Albert Eliseo , Carbonell Nieves , Ferreres José , Sánchez Gloria , Rodríguez-Díaz Jesús , Blasco María Luisa , Navarro David 
Published: May 2022

AbstractCombined kinetic analysis of plasma SARS-CoV-2 RNAemia, Nucleocapsid (N)-antigenemia and virus-specific antibodies may help ascertain the role of antibodies in preventing virus dissemination in COVID-19 patients. We performed this analysis in a cohort of 71 consecutive critically ill COVID-19 patients (49 male; median age, 65 years) using RT-PCR assay, lateral flow immunochromatography method and receptor binding domain (RBD) and N-based immunoassays. A total of 338 plasma specimens collected at a median of 12 days after symptoms onset were available for analyses. SARS-CoV-2 RNAemia and N-antigenemia were detected in 37 and 43 specimens from 26 (36.5%) and 30 (42.2%) patients, respectively. Free RNA was the main biological form of SARS-CoV-2 found in plasma. The detection rate for both viral components was associated with viral load at the upper respiratory tract. Median time to SARS-CoV-2-RBD antibody detection was 14 days (range, 4–38) from onset of symptoms. Decreasing antibody levels were observed in parallel to increasing levels of both RNAemia and N-antigenemia, yet overall a fairly modest inverse correlation (Rho = −0.35; P < 0.001) was seen between virus RNAemia and SARS-CoV-2-RBD antibody levels. The data cast doubts on a major involvement of antibodies in virus clearance from the bloodstream within the timeframe examined.
Response comparison of PLC and SLC with magnetic resonance elastography after TACE
Authors: Haas Y. , Dosch M. P. , Vogl T. J. 
Published: May 2022

AbstractThe aim of this study was to detect a response difference in primary (PLC) and secondary liver tumors (SLC) with magnetic resonance elastography (MRE) after TACE therapy. Thirty-one patients (25/31 male; mean age 69.6 years [range: 39–85 years]) with repeated TACE therapy of HCC were compared with twenty-seven patients (27/27 female; mean age 61.2 years [range 39–81 years]) with repeated TACE therapy of metastatic liver disease due to breast cancer. Both groups underwent either one (n = 31) or two (n = 27) repetitive magnetic resonance imaging (MRI) and MRE exams in 4- to 6-week intervals using a 1.5-T-scanner. MRE-based liver stiffness and size measurements were evaluated in tumorous lesions and in healthy liver lobe controls. PLC showed a significantly larger tumor size compared to SLC (26.4 cm2 vs. 11 cm2, p = 0.007) and a higher degree of stiffness (5.8 kPa vs. 5.1 kPa, p = 0.04). Both tumors decreased in size during the cycles (PLC: p = 0.8 and SLC: p < 0.0001) and lesions showed an increase in stiffness (PLC: p = 0.002 and SLC: p = 0.006). MRE demonstrates that PLC and SLC have similar responses to TACE therapy. PLC had a greater increase in stiffness and SLC got smaller. An increasing stiffness and decrease in size could show a good response.
Genome analysis in Avena sativa reveals hidden breeding barriers and opportunities for oat improvement
Authors: Tinker Nicholas A. , Wight Charlene P. , Bekele Wubishet A. , Yan Weikai , Jellen Eric N. , Renhuldt Nikos Tsardakas , Sirijovski Nick , Lux Thomas , Spannagl Manuel , Mascher Martin 
Published: May 2022

AbstractOat (Avena sativaL.) is an important and nutritious cereal crop, and there is a growing need to identify genes that contribute to improved oat varieties. Here we utilize a newly sequenced and annotated oat reference genome to locate and characterize quantitative trait loci (QTLs) affecting agronomic and grain-quality traits in five oat populations. We find strong and significant associations between the positions of candidate genes and QTL that affect heading date, as well as those that influence the concentrations of oil and β-glucan in the grain. We examine genome-wide recombination profiles to confirm the presence of a large, unbalanced translocation from chromosome 1 C to 1 A, and a possible inversion on chromosome 7D. Such chromosome rearrangements appear to be common in oat, where they cause pseudo-linkage and recombination suppression, affecting the segregation, localization, and deployment of QTLs in breeding programs.
Navigating the minefield of battery literature
Authors: Xu Kang 
Published: May 2022

AbstractThe field of battery research is highly active with an ever-increasing number of publications. This makes it extremely challenging for researchers to stay on top of the latest developments. In addition, and particularly challenging for those new to the battery field, a number of fundamental errors or inaccuracies frequently occur in published papers, creating additional barriers to understanding an already complicated field. Such errors and inaccuracies are potentially problematic given how battery research is focused toward those materials with promising performance metrics, which subsequently influences where research efforts are placed. This discussion seeks to clarify a few such recurring errors and inaccuracies, including electrolyte ideality, ion conduction and transference, Sand’s time and lithium-dendrite, cycle number and reversibility, and capacity and energy calculations. This discussion is intended to encourage researchers to follow rigorous reporting standards when publishing their battery research, which will help to ensure that findings can be reproduced by others.
Performance measurement based on machines data: Systematic literature review
Authors: Hidalgo Martins Gleison , Deschamps Fernando , Pereira Detro Silvana , Valle Pablo Deivid 
Published: May 2022

AbstractIndustry 4.0 driven by the internet of things (IoT) is changing the way of producing and has been offering smart manufacturing systems with support technologies for the digital transformation of manufacturing plants seeking improvements in productivity, in control over the process, and customisation of production, among others. Due to these technological developments, small and medium‐sized industries have been identified as a weak link in adapting their processes and resources, where they are usually the biggest victims in the transition to industry 4.0. The evidence points out that the excess data inserted in the databases of the manufacturing system of the industries influences the decision‐making process of managers, making the process more complex and dynamic. This research focuses on a systematic literature review to assess how data‐based performance measurements for machines are being handled in the context of industry 4.0. The methodological approach follows the application of the PROKNOW‐C (Knowledge Development Process‐Constructivist) method used to build a Bibliographic Portfolio in a structured way in line with the research theme. The results presented in the Bibliometric Analysis enabled the construction of a performance measurement model based on the sources of the researched articles.
A wireless charging algorithm for rechargeable wireless sensor networks in coal mines faces
Authors: Hu Qingsong , Cheng Yong , Li Binghao , Li Shiyin , Sun Yanjing 
Published: May 2022

AbstractThe working face is the most dangerous place of coal mines, and it is difficult (even impossible) to replenish energy by replacing batteries of sensor nodes in the working faces. This paper presents a wireless charging method for this scenario that is composed of two sub methods called mining charging and maintaining charging, respectively. Mining charging provides opportunistic charging services during the process of coal cutting through two airborne Mobile Chargers (MCs) installed on the two ends of the shearer and two portable MCs carried by shearer drivers. Maintaining charging provides opportunistic charging services for nodes in the charging radius when scraper conveyor repairmen and hydraulic support repairmen check or repair equipment, with each repairman carrying one portable MC. Simulation results show that both mining charging and maintaining charging can give energy replenishment for nodes in coal faces. When charging power of MCs is greater than or equal to 5.2 W, the first row of nodes can work sustainably. If the energy requirements of the second row of nodes are also met, the charging power of MCs cannot be less than 12 W.
Secret key generation based on signal power allocation optimisation
Authors: Lu Xinjin , Lei Jing , Li Wei 
Published: May 2022

AbstractWith the rapid development of wireless communication, the use of the inherent features of wireless channels to enhance and supplement existing security mechanisms has attracted widespread attention. In this work, a key generation scheme based on power allocation optimisation is proposed. The subchannel state information obtained from channel probing is employed to allocate signal power. Furthermore, an improved channel probing process is designed to implement the optimisation scheme of power allocation. Theoretical analysis and simulation results show that this optimisation scheme can obtain higher key capacity, and the superiority is more prominent when the signal‐to‐noise ratio is low. Besides, the key bits mismatch rate of the proposed optimisation scheme is decreased and the corresponding key generation rate is higher compared with the benchmark.
Over‐the‐air equalization with reconfigurable intelligent surfaces
Authors: Arslan Emre , Yildirim Ibrahim , Kilinc Fatih , Basar Ertugrul 
Published: May 2022

AbstractReconfigurable intelligent surface (RIS)‐empowered communications is on the rise and is a promising technology envisioned to aid in 6G and beyond wireless communication networks. RISs can manipulate impinging waves through their electromagnetic elements enabling some sort of control over the wireless channel. The potential of RIS technology is explored to perform a sort of virtual equalization over‐the‐air for frequency‐selective channels, whereas equalization is generally conducted at either the transmitter or receiver in conventional communication systems. Specifically, using an RIS, the frequency‐selective channel from the transmitter to the RIS is transformed to a frequency‐flat channel through elimination of inter‐symbol interference (ISI) components at the receiver. ISI is eliminated by adjusting the phases of impinging signals particularly to maximize the incoming signal of the strongest tap. First, a general end‐to‐end system model is provided and a continuous to discrete‐time signal model is presented. Subsequently, a probabilistic analysis for elimination of ISI terms is conducted and reinforced with computer simulations. Furthermore, a theoretical error probability analysis is performed along with computer simulations. It is analysed and demonstrated that conventional RIS phase alignment methods can successfully eliminate ISI, and the RIS‐aided communication channel can be converted from frequency‐selective to frequency‐flat.
Magnetic integrated LLCL filter with resonant frequency above Nyquist frequency
Authors: Al‐Barashi Maged , Wu Siqi , Liu Zhigang , Meng Xiangyu , Tasiu Ibrahim Adamu 
Published: May 2022

AbstractThis paper presents a design technique of magnetic integrated LLCL filters for grid‐tied inverters. With the proposed design technique, the LLCL filter's resonant frequency can be higher than the Nyquist frequency. Furthermore, the proposed concept was only reported for the LCL filter in the previous research works. In addition, the modulation process will produce dominant switching harmonics for unipolar PWM H‐bridge inverters at the double switching frequency. Thus, putting the resonant frequency beyond the Nyquist frequency will increase the stability zone. The proposed design methods maximize the filter inductors' utilization and resist the grid impedance variations under weak grid conditions, depending on the improved stability zone. Comparative simulation and HIL experimental results are presented to confirm the effectiveness of the proposed magnetic integrated LLCL filter design. The HIL experimental results and the simulation results agree well with each other.
Einfluss der perioperativen Echokardiografie auf das chirurgische Management
Authors: Mehrländer Martin , Magunia Harry 
Published: May 2022

ZusammenfassungDie perioperative Echokardiografie dient als bildgebendes Verfahren nicht nur der Darstellung von anatomischen Strukturen – in geübten Händen kann sie auch dynamische Funktionsänderungen
der Herz- und Klappenfunktion darstellen. Dieser Artikel beschreibt Einsatzgebiete der perioperativen transösophagealen Echokardiografie bei (herz-)chirurgischen Eingriffen und geht auf den
Einfluss dieser Technik auf das operative Ergebnis ein.
Vemurafenib effectively controlled Chemotherapy-refractory Intrahepatic Cholangiocarcinoma with BRAF V600E Mutation: a case report and literature review
Authors: Weng Shanshan , Zhang Ding , Yang Mengyuan , Wang Liuhong , Yuan Ying 
Published: May 2022

Zusammenfassung
Hintergrund Die Chemotherapie ist die erste Behandlungsoption für das lokal fortgeschrittene oder metastasierte intrahepatische Cholangiokarzinom (ICC). Nach einer Erstlinien-Chemotherapie gibt es jedoch keine Standardzweitlinienbehandlung oder zielgerichtete Wirkstoffe für diese Patienten.
Fallpräsentation Hier stellen wir einen fortgeschrittenen ICC-Patienten vor, der eine radikale Entfernung und eine adjuvante Chemotherapie (Gemcitabin + Cisplatin) erhalten hat. Aber der Patient bleibt nur 6 Monate frei von Krankheitsanzeichen (No Evidence of Disease) nach dem Ende der Chemotherapie. Dann erhielt er eine palliative Operation, Strahlentherapie und systemische Chemotherapie (Tegafur+Oxaliplatin (SOX) und Nab-Paclitaxel+Gemcitabin (AG)). Leider war die Krankheit immer noch nicht unter Kontrolle. Als eine BRAF-V600E-Mutation im Tumorgewebe durch eine Next Generation Sequencing Analyse (NGS) gezeigt wurde, begann dieser Patient mit der Einnahme von Vemurafenib in einer Dosierung von 720–960 mg zweimal täglich und erreichte ein progressionsfreies Überleben von 7 Monaten mit signifikanter Remission der klinischen Symptome.
Schlüsselwörter Die BRAF V600E Mutation ist bei ICC ziemlich selten, daher wird sie in der Klinik nicht routinemäßig untersucht. Allerdings kann Präzisionsmedizin durch die NGS-Technologie verwirklicht werden, sodass die Ärzte bei der Behandlung der auf Chemotherapie-refraktären ICC die personalisierten genomischen Informationen nutzen können.
Clinical trial transparency in gastrointestinal endoscopy research
Authors: Garg Shashank , Rizvi Anam , Wee Diana , Rizvi Youshaw , Rizvi Fatima , Rizvi Anza , Thomas Sheila Louise , Inamdar Sumant , Trindade Arvind J. 
Published: May 2022

Abstract
Background Under-reporting of clinical trial results can lead to negative consequences that include inhibiting propagation of knowledge, limiting the understanding of how devices work, affecting conclusions of meta-analyses, and failing to acknowledge patient participation. Therefore clinical trial transparency, through publication of trial results on ClinicalTrials.gov or in manuscript form, is important. We aimed to examine clinical trial transparency in endoscopic clinical trials.
Methods The ClinicalTrials.gov database was searched for endoscopy trials up to October 2019. Adherence to the reporting of results to the database or in publication form was recorded for each trial.
Results The final analysis included 923 trials, of which 801 were completed and 122 were either terminated or suspended. Results were available either on ClinicalTrials.gov or in publication for 751/923 trials (81.4 %). Other fields have reported a publication rate of 40 %–63 %. Results were available on ClinicalTrials.gov for 168 trials (18.2 %) and in the form of a publication for 720 trails (78.0 %).
Conclusions Compared with other fields in medicine, endoscopy clinical trials have a high rate of clinical trial transparency. However, there is room for improvements as close to one-fifth of trials fail to report results and 81.8 % do not report results to ClinicalTrials.gov.
Major League Baseball during the COVID-19 pandemic: does a lack of spectators affect home advantage?
Authors: Chiu Yung-Chin , Chang Chen-Kang 
Published: May 2022

AbstractA home advantage is present in most professional sports leagues. Spectators may be a major factor in home advantage, but empirical results have been mixed. Professional games were played without spectators during the 2020 season amid the COVID-19 pandemic. This study investigated home advantage in Major League Baseball (MLB) during 2020 as compared with the 2015–2019 seasons. A total of 13,044 regular-season games (898 in 2020 and 12,146 in 2015–2019) were analyzed. The sum of wins above replacement of all players was used as an indicator of team quality. The likelihood of a home-team win with spectators was not significantly different to that without spectators (odds ratio = 1.068; 95% confidence interval = 0.932–1.224, p > 0.05). The relative home advantage, percentage of home wins of total wins by a team in a specific season, was not significantly different across years, team quality, and attendance. Factorial analysis of variance models that included the variables of year, team quality, and attendance also revealed that none of these variables significantly affected the relative home advantage. The results suggest that spectators may not be an important factor of home advantage in MLB.
Composition-dependent sign inversion of the Soret coefficient of SiO2 in binary borosilicate melts
Authors: Shimizu Masahiro , Sato Kenzo , Nakashima Kento , Kiyosawa Tomohiro , Matsuoka Jun , Shimotsuma Yasuhiko , Miura Kiyotaka 
Published: May 2022

Using a laser-induced local-heating experiment combined with temperature analysis, we observed the composition-dependent sign inversion of the Soret coefficient of SiO2 in binary silicate melts, which was successfully explained by a modified Kempers model used for describing the Soret effect in oxide melts. In particular, the diffusion of SiO2 to the cold side under a temperature gradient, which is an anomaly in silicate melts, was observed in the SiO2-poor compositions. The theoretical model indicates that the thermodynamic mixing properties of oxides, partial molar enthalpy of mixing, and partial molar volume are the dominant factors for determining the migration direction of the SiO2 component under a temperature gradient.
Increasing fire severity negatively affects greater glider density
Authors: May-Stubbles Jarrah C. , Gracanin Ana , Mikac Katarina M. 
Published: May 2022

Context Fire severity and frequency is predicted to increase over the remainder of the 21st century in Australia’s temperate forests; therefore, the effects of fire severity on forest-dependant species is of major conservation concern. Aims Determining the short-term (<1 year) effect of fire severity on a forest-dependant species, the greater glider, Petauroides volans, in Monga National Park, south-eastern New South Wales. Methods Three fire-severity classes were investigated, namely, low (canopy unburnt), moderate (partial canopy burn) and high (complete canopy consumption). Fifteen randomly allocated sites were visited in total, with five sites in each fire-severity class being visited on three separate occasions. Spotlighting of two off-track transects per site was completed over a 4-week period by using multi-covariate distance sampling (MCDS) to estimate greater glider densities at each fire-severity class. Key results An overall mean greater glider density estimate of 0.456 ha−1 (95% confidence interval (CI) 0.256–0.654 ha−1) was calculated across all sites in Monga National Park. Density estimates varied among fire-severity classes; low 0.779 ha−1 (95% CI 0.358–1.692 ha−1), moderate 0.472 ha−1 (95% CI 0.262–0.848 ha−1), and high 0.077 ha−1 (95% CI 0.0142–0.414 ha−1). Conclusions Distance sampling estimates suggested that areas affected by high-severity fire have lower densities of greater gliders. Implications The importance of areas experiencing low fire severity as a source of greater glider refugia during wildfire events is evident. Under a changing climate, frequent major wildfire events may significantly affect population viability of greater gliders if insufficient time between fires allow for population recovery.
H3K9 methylation drives resistance to androgen receptor–antagonist therapy in prostate cancer
Authors: Baratchian Mehdi , Tiwari Ritika , Khalighi Sirvan , Chakravarthy Ankur , Yuan Wei , Berk Michael , Li Jianneng , Guerinot Amy , de Bono Johann , Makarov Vladimir , Chan Timothy A. , Silverman Robert H. , Stark George R. , Varadan Vinay , De Carvalho Daniel D. , Chakraborty Abhishek A. , Sharifi Nima 
Published: May 2022

Significance
This study reveals that antiandrogen therapy induces viral mimicry responses that are crucial for antitumor activity. H3K9 trimethylation to silence endogenous repeat elements is essential for regaining heterochromatin stability and progression to antiandrogen resistance in prostate cancer. We found that the H3K9 trimethylation machinery is linked to poor outcomes in men with prostate cancer. Blockade of this epigenetic axis can resensitize drug-resistant tumors and elicit cytotoxic interferon responses. Antiandrogen timing and regulation of the H3K9 methylation–endogenous repeat elements– interferon axis should be considered in the development of novel epigenetic therapies and immunotherapeutic strategies for prostate cancer.
Hydration-mediated G-protein–coupled receptor activation
Authors: Fried Steven D. E. , Hewage Kushani S. K. , Eitel Anna R. , Struts Andrey V. , Weerasinghe Nipuna , Perera Suchithranga M. D. C. , Brown Michael F. 
Published: May 2022

Significance
Although G-protein–coupled receptors (GPCRs) control vast physiological pathways, their activation remains chemically and physically enigmatic. Our osmotic stress studies of the visual receptor rhodopsin have redefined the standard model of GPCR signaling by revealing the essential role of bulk water. We show results consistent with a large number of water molecules flooding the rhodopsin interior during activation to stabilize the effector binding conformation. These results suggest a model of GPCR activation in which the receptor becomes solvent-swollen upon formation of the active state. We thus demonstrate the mechanism whereby water acts as a powerful allosteric modulator of a pharmacologically important membrane protein family.
NOS2 and
S
-nitrosothiol signaling induces DNA hypomethylation and LINE-1 retrotransposon expression
Authors: Switzer Christopher H. , Cho Hyun-Ju , Eykyn Thomas R. , Lavender Paul , Eaton Philip 
Published: May 2022

Significance
Nitric oxide is a multifaceted signaling molecule that affects multiple pathways and cellular systems. Here, we report that inducible nitric oxide synthase expression, which is strongly correlated with inflammation and poor outcomes in patients with cancer, substantially alters DNA methylation to regulate cellular plasticity. Our data connect inflammation mechanistically with stress signals, DNA demethylation, and genotoxic retrotransposon expression. Passive DNA demethylation occurs during conditions of reduced DNA (cytosine-5)–methyltransferase 1 (DNMT1) activity; however, the cellular pathways that control passive demethylation are not clear. Our results show that sustained cellular stress signals result in DNMT1 protein loss and DNA hypomethylation, similar to DNMT1 inhibition by 5-azacytidine. This implies that chronic inflammation drives cellular transformation via DNA hypomethylation and retrotransposon activation.