bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contralateral lymph node metastasis in recurrent ipsilateral breast cancer with Lynch syndrome: a locoregional event
Authors: Zwimpfer Tibor Andrea , Schwab Fabienne Dominique , Steffens Daniel , Kaul Felix , Schmidt Noemi , Geiger James , Geissler Franziska , Heinzelmann-Schwarz Viola , Weber Walter Paul , Kurzeder Christian 
Published: August 2022

Abstract
Introduction Contralateral axillary lymph node metastasis (CALNM) in breast cancer (BC) is considered a distant metastasis, marking stage IV cancer. Therefore, it is generally treated as an incurable disease. However, in clinical practice, staging and treatment remain controversial due to a paucity of data, and the St. Gallen 2021 consensus panel recommended a curative approach in patients with oligometastatic disease. Aberrant lymph node (LN) drainage following previous surgery or radiotherapy is common. Therefore, CALNM may be considered a regional event rather than systemic disease, and a re-sentinel procedure aided by lymphoscintigraphy permits adequate regional staging.Case report: Here, we report a 37-year-old patient with Lynch syndrome who presented with CALNM in an ipsilateral relapse of a moderately-differentiated invasive ductal BC (ER 90%, PR 30%, HER2 negative, Ki-67 25 %, microsatellite stable), three years after the initial diagnosis. Lymphoscintigraphy detected a positive sentinel LN in the contralateral axilla despite no sign of LN involvement or distant metastases on FDG PET/CT or MRI. The patient underwent bilateral mastectomy with sentinel node dissection, surgical reconstruction with histological confirmation of the CALNM, left axillary dissection, adjuvant chemotherapy, and anti-hormone therapy. In addition to her regular BC follow-up visits, the patient will undergo annual colonoscopy, gastroscopy, abdominal, and vaginal ultrasound screening. In February 2022 the patient was free of progression for 8 months after last chemotherapy.Conclusion This case highlights the value of delayed lymphoscintigraphy and the contribution of sentinel procedure for local control in the setting of recurrent BC. Aberrant lymph node drainage following previous surgery may be the underlying cause of CALNM. We propose that CALNM without evidence of systemic metastasis should be considered a regional event in recurrent BC, and thus a curative approach can be pursued. The next AJCC BC staging should clarify the role of CALNM in recurrent BC to allow for the development of specific treatment guidelines.
Detrital zircon grains analyzed for U-Pb ages for sedimentary provenance studies: Tectonic- driven deposition of the Resende Basin (Eocene-Oligocene) in SE Brazil
Authors: Oliveira Carlos Eduardo Sales , Santos Werlem Holanda , Tavares Armando Dias , Chaves Hernani , Appi Ciro , Martins Maria Virginia Alves , Geraldes Mauro Cesar 
Published: August 2022

Abstract

The Resende Basin (Eocene-Oligocene) is a continental taphrogenic structure associated with the Continental Rift of Southeast Brazil and includes the Itatiaia and Acácias members. While the sediment provenance of the Itatiaia member is known, such knowledge regarding the Acácias Member is lacking. This work studies U-Pb ages and Lu-Hf data analyzed by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) in detrital zircons to investigate the sandstone provenance of the Acácias Member. The results suggest that Acácias Member rocks are composed predominantly of Neoproterozoic sources (60%), significant Paleoproterozoic sources (34%) and smaller contributions from Mesoproterozoic (4%) and Archean (2%) sources. The orthogneisses of the Juiz de Fora and Quirino complexes and the metasedimentary rocks of the Andrelandia Complex and Paraíba do Sul were probably the source rocks of Archean and Paleoproterozoic materials. The metasedimentary Embú Complex may be the source of Mesoproterozoic sediments, and the granitoid bodies located south of the Resende Basin (namely,the Rio Turvo granitoid) were important Neoproterozoic sources. No Late Cretaceous ages were found in the 301 analyzed zircons, suggesting that the extensional process that originated in the basin occurred before the Itatiaia alkaline intrusions. In addition, other causes for the lack of zircon grains with the age of alkaline intrusive rocks (Morro Redondo ≈72-70 Ma; Itatiaia ≈70 Ma) may have been related to the basin location with a structural high that could have prevented the alkaline detritus from the Itatiaia and Morro Redondo intrusive bodies from reaching the study area and restricted the supply of sediments from a fluvial system with tributaries on the northern edge. In conclusion, the results of this work reveal that U-Pb ages in detrital zircons reveal a tectonic-driven of the Resende basin sediments. In this way, interpretations of tectonic environments that affected sedimentation require a thorough understanding of the lithological units that compose the basin stratigraphy and factors such as the directions of currents and the presence of structures that compartmentalized sedimentary processes.
Outpatient Nutritional Screening and Rehabilitation of Malnourished Egyptian Children: Are Rural Areas at More Risk?
Authors: Nassar May , Abdel-Wahed Mohamed , Abdelhaleem Basma , Ahmed Ahmed , Kholy Heba El 
Published: August 2022

Abstract
Background
Malnutrition presents a major global health burden. In Egypt, it remains an important issue in children under 5 years especially in urban communities. This increased the interest in screening the pediatrics outpatient clinics for early detection and proper management of malnutrition.
Aim of the study:
The aim of the study was to screen 2–5 years old children enrolled from Egyptian hospitals in rural and urban areas for the risk of malnutrition using Screening Tool for Assessment of Malnutrition in Pediatric (STAMP) and to evaluate the effectiveness of nutritional intervention program.
Subjects and Methods:
This cross-sectional study was conducted on 90 patients recruited from Bolaque El-Dakror hospital in urban Cairo, and El-Badrashine hospital representing rural areas. Dietary history and anthropometric measurements were assessed. Patients at intermediate and severe risk of malnutrition according to STAMP were given tailored nutritional programs and were followed up.
Results
In the rural hospital, 4.4% of the screened children were underweight, 22.2% were marginally underweight, and 73.3% had normal weight. Regarding the urban hospital, 15.6% were marginally underweight, 84.4% had normal weight and no patients were underweight. Among the rural group 46.7% were at low risk of malnutrition, 17.8% were at intermediate risk and 35.6% were at high risk according to STAMP score results. In the urban group 71.1% were at low risk, 8.9% were at intermediate risk and 20% were at high risk. Nevertheless, the only significant differences were the more stunting and higher BMI in rural hospital patients. After nutritional intervention, high-risk category patients decreased in both groups coupled by significant improvement in the anthropometric parameters and nutrition data with no significant differences between them.
Conclusion
Nutritional education and prompt implementation of nutritional rehabilitation program for malnourished children detected by screening tools result in improvement in their nutritional status disregards their location whether urban or rural.
Clinical Outcomes and Weight Loss Trend After Bariatric Surgery in a Population of Obese Patients
Authors: Palumbo Patrizia , Banchelli Federico , Miloro Clelia , Toschi Patrizia Federica , Mecheri Fouzia , Gabriele Silvia , Pantaleoni Monica , D'Amico Roberto , Menozzi Renata 
Published: August 2022

Abstract
Purpose
Bariatric Surgery (BS) is a therapeutic option in patients with severe obesity whosenon-surgical techniques have failed. No work has previously explored trajectories of weight loss and how long this was maintained. Aim of study is to describe effect of BS and nutritional intervention on body weight trend in patients with obesity.
Subjects/Methods:
792 patients who underwent BS from 1996 to 2021 were included. The Protocol provides Laparoscopic Sleeve Gastrectomy (LSG), Vertical Gastroplasty (VBG) and Roux-en-Y Gastric Bypass (GB%). %Total Weight Loss (%TWL) and %Excess Weight Loss (%EWL) were evaluated in three cohort of patients. Cumulative incidence of clinical goal after surgery was calculated at two and five years after BS.
Results
At two years of follow-up, average %TWL and %EWL were 31.2% (95% CI = 29.0–33.4%) and 71% (95% CI = 65.4–76.5%) for VBG, 34.7% (95% CI = 33.8–35.6%) and 78.0% (95% CI = 75.9–89.1%) for GB and 33.8% (95% CI = 32.5–35.1%) and 68.8% (95% CI = 66.1–71.6%) for LSG. At 2 years from surgery the cumulative incidence of clinical goal was 70.7% (95% CI = 59.1–79.1%) for VBG, 86.4% (95% CI = 82.4–89.6%) for GB and 83.4% (95% CI = 76.0–87.1%) for LSG.
Conclusions
Our work confirm effectiveness of BS in patients with obesity and show that who don’t reach clinical goal within 2 years, hardly will reach it later and suggest necessity for a medium and long-term follow up to prevent weight regain.
How do we choose the appropriate deep learning method for our case? A systematic literature review
Authors: Saputra Nisa Aulia , Riza Lala Septem , Setiawan Agus , Hamidah Ida 
Published: August 2022

Abstract
In the era of technology 4.0, there are many problems in multiple sectors of life that are difficult for humans to solve, ranging from issues in the education quality performance system, difficulties in disease diagnosis, problems in manufacturing systems, construction, food grading, quality control, Etc. Various efforts have been made to solve these problems, from the conventional method of manually retrieving data to obtain the best solution to using a big data-based approach with deep learning. Deep learning has successfully solved problems in various sectors, proving that using big data on deep learning algorithms gives significant results. This systematic review aims to review the studies that have been carried out on applying deep learning to solve or help problems in various sectors. This systematic review shows an overview of deep learning neural networks created in the completion process, the differences in the artificial intelligent methods used, and the advantages and disadvantages of deep learning in various models. It identifies challenges and recommendations for the future. The methods used in this systematic review include search strategies, selecting literature studies, and managing and extracting data. Based on the systematic review results, we know that Convolutional Neural Network (CNN) is the most widely used model for this deep learning algorithm to recognize the feature, along with the image-based data transformation strategy. Finally, deep learning has become very popular because it can transform various data types to get the desired result.
Evaluating a Research Training Programme for Frontline Health Workers in Conflict-Affected and Fragile Settings in the Middle East
Authors: Naal Hady , Daou Tracy , Brome Dayana , Mansour Rania , Sittah Ghassan Abu , Giannou Christos , Steiger Enrique , Saleh Shadi 
Published: August 2022

Abstract
Background
Health Research Capacity Building (HRCB) is key to improving standards of research in low- and middle-income countries (LMICs), which would help inform appropriate policies and reduce health disparities in conflict settings. However, few HRCB programmes are available in the Middle East and North Africa (MENA) region, and few evaluations of HRCB globally are reported in the literature.
Methods
Through a qualitative longitudinal design, we evaluated the first implementation of the Centre for Research and Education in the Ecology of War (CREEW) fellowship. Semi-structured interviews were conducted with fellows (n = 5) throughout the programme at key phases during their completion of courses and at each research phase. Additional data was collected from supervisors and peers of fellows at their professional organisations. Data were analysed using qualitative content analysis and presented under pre-identified themes.
Results
Despite the success of most fellows in learning how to conduct research on antimicrobial resistance (AMR) in conflict settings and completing the fellowship by producing research papers, important challenges were identified. Results are categorised under predefined categories of (1) course delivery, (2) proposal development, (3) Institutional Review Board (IRB) application, (4) data collection, (5) data analysis, (6) manuscript write-up, (7) long-term effects, and (8) mentorship and networking.
Conclusion
The CREEW model, based on this evaluation, shows potential to be replicable and scalable to other contexts and other health-related topics. Detailed discussion and analysis are presented in the manuscript and synthesised recommendations are highlighted for future programmes to consider during the design, implementation, and evaluation of such programmes.
Homogeneous inhibition is optimal for the phase precession of place cells in the CA1 field
Authors: Vandyshev Georgy , Mysin Ivan 
Published: August 2022

Abstract
Place cells are hippocampal neurons encoding the position of an animal in space. Studies of place cells are essential to understanding the processing of information by neural networks of the brain. An important characteristic of place cell spike trains is phase precession. When an animal is running through the place field, the discharges of the place cells shift from the ascending phase of the theta rhythm through the minimum to the descending phase. The role of excitatory inputs to pyramidal neurons along the Schaffer collaterals and the perforant pathway in phase precession is described, but the role of local interneurons is poorly understood. Our goal is estimation of the contribution of field CA1 interneurons to the phase precession of place cells using mathematical methods. The CA1 field is chosen because it provides the largest set of experimental data required to build and verify the model. Our simulations discover optimal parameters of the excitatory and inhibitory inputs to the pyramidal neuron so that it generates a spike train with the effect of phase precession. The uniform inhibition of pyramidal neurons best explains the effect of phase precession. Among interneurons, axo-axonal neurons make the greatest contribution to the inhibition of pyramidal cells.
Major and minor ECG abnormalities depending on regional living conditions in Russia
Authors: Maksimov Sergey , Muromtseva Galina , Kutsenko Vladimir , Shalnova Svetlana , Evstifeeva Svetlana , Drapkina Oksana 
Published: August 2022

Abstract
The goal of our study was to explore the effect of living conditions on the likelihood of major and minor ECG abnormalities on a large region scale in Russia. For the analysis, cross-sectional data of the Russian study, ESSE-RF 2013-2014, were used. They were collected on a sample of 16,400 subjects from 10 regions of the Russia. ECG abnormalities were grouped into two categories: Major and Minor (sensu the 2009 version of the Minnesota Code Classification System). Regional living conditions were considered comprehensively via five indices combining 33 characteristics of the regions. The estimates were presented as odds ratios and their 95% confidence intervals. The prevalence values of major abnormalities in the sample were 8.4% among women and 9.4% among men (p=0.021). The prevalence of minor abnormalities constituted 34.1% and 45.9%, respectively (p<0.001). In men, the likelihood of major ECG abnormalities increased with the demographic depression growth (1.08: 1.04-1.12) and with industrial development growth in the region (1.12: 1.07-1.17). In women, an increase in the likelihood of major ECG abnormalities was directly associated with industrial development (1.12: 1.07-1.16) and inversely related to the economic development in the region (0.94: 0.89-0.99). The probability of minor ECG abnormalities in men and women declined with the growth of the regional economic development: OR of 0.95: 0.93-0.98, and OR of 0.92: 0.87-0.99, respectively. The study demonstrated an effect of regional living conditions of the Russian population on the likelihood of major and minor ECG abnormalities. The most stable and logically explainable relationships were obtained for industrial and economic characteristics of living conditions.
Determining the compositional nutrient diagnosis (CND) norms and main nutrient interactions in 'Golden Delicious' apple on calcareous soils
Authors: Tadayon Mohammad Saeed , Saghafi Kobra , Sadeghi Sohrab 
Published: August 2022

Abstract

Balanced nutrition, especially under environmental stress have a great effect on improving the performance of fruit trees. Under such condition, establishing the leaf nutrient reference norms are essential to determining the nutritional balance in ‘Golden Delicious’ apple orchards. For this purpose, the leaf nutrient concentrations and yields of 81 commercial orchards were determined. The orchard's nutritional status was evaluated through the CND method and principal component analysis (PCA). The CND reference norms were calculated as V*N = 2.714 ± 0.183, V*P = 0.187 ± 0.091, V*K = 2.553 ± 0.043, V*Ca = 2.622 ± 0.075, V*Mg = 1.204 ± 0.045, V*S = 0.860 ± 0.089, V*Fe = -0.929 ± 0.173, V*Mn = -3.251 ± 0.147, V*Zn = -4.052 ± 0.332, V*Cu = -5.058 ± 0.208, V*B = -3.258 ± 0.059, V*Rd = 6.409 ± 0.050. According to PCA analysis, increment of the leaf S, Ca, B, N and Fe concentration in the low yielding subpopulation, respectively had a significant effect on the increasing of fruit yield in ‘Golden Delicious’ apple orchards. The reduction of global nutrient imbalance index (CND-r2) to below 17.64 can significantly increase the productivity of ‘Golden Delicious’ apple orchards in calcareous soil conditions.
Exploiting potentialities for space-based quantum communication network: downlink quantum key distribution modelling and scheduling analysis
Authors: Wang Xingyu , Dong Chen , Wei Jiahua , Wu Tianyi , Yu Huicun , Zhao Shanghong , Shi Lei 
Published: August 2022

Abstract
With the goal of a space-based quantum network is to have satellites distribute keys between any nodes on the ground, we consider an evolved quantum network from a near-term form, in which a space-based relay, satellite executes a sequence of satellite-based quantum key distribution (SatQKD) missions, allowing any two ground nodes to have a shared secure key. Accordingly, we develop a comprehensive framework for the dynamic simulation of SatQKD and consider scheduling QKD downlink in future space-based quantum communication network. The embedding of precise orbital model including beam diffractions and atmosphere effects makes our framework more realistic. Incorporated with the local meteorological data to channel loss model, the cloud cover contribution to transmission disturbance is quantified to realize a quasi-experimental scenario. We provide a trade-off consideration between the duration available for communications and its corresponding average link loss during one orbit, which could be used to support decisions involving the locations of ground stations and the selection of the orbital parameters for a quantum satellite. Our work also shows that satellite downlink schedule could allow for the possibility to consider strategies for different SatQKD missions such as extending connection for distant ground nodes, prioritized delivery, or promoting keys utilization, which can be used as a guideline to support decisions for future satellite application.
Strength and Durability Performance of Mortars Incorporating Calcined Clay as Pozzolan
Authors: Beyki Hadi , Dousti Ali , Shekarchi Mohammad 
Published: August 2022

Abstract
The use of low-grade calcined clays is the only potential material available in large quantities to meet the requirements of eco-efficient supplementary cementitious materials by decreasing the clinker content in blended cements or decreasing the cement content in concrete.In the present paper, six mortar mixtures with a constant w/b ratio were used to investigate mechanical and durability properties of mixtures substituted with low-grade calcined clays with/without limestone compared to PC and silica fume mixtures. The present research have shown that using calcined clays with low or intermediate purity (i.e., kaolinite content) leads to enhanced durability properties besides the comparable strength development characteristics compared to PC mortar. The results also indicate the superiority of low or intermediate calcined clay (> 40% kaolinite content) binder over silica fume binder in producing durable mortar mixture, especially in a chloride laden environment. The major reason for the better performance is attributed to the refined pore structure and dense microstructure of the cement paste with the calcined clay pozzolan compared to PC and silica fume.
Effects of lifestyle risk behaviour clustering on cardiovascular disease among UK adults: latent class analysis with distal outcomes
Authors: TEGEGNE Teketo , Islam Shariful , Maddison Ralph 
Published: August 2022

Abstract
Background: Lifestyle risk behaviours such as smoking, physical inactivity, and unhealthy diet account for a considerable disease burden worldwide. These lifestyle behaviours tend to cluster within an individual that could have synergetic effects on health. In this study, we aimed to examine the effect of lifestyle risk behaviour clustering (smoking, poor fruit and vegetable consumption, alcohol intake, physical inactivity, prolonged sitting, and poor sleep) on cardiovascular disease (CVD) and CVD risk among adults in the United Kingdom (UK).Methods: We used baseline (2006-2010) data from the UK Biobank. We performed a latent class (LC) analysis with distal outcomes model to identify and estimate the effect of clustering of lifestyle risk behaviours and socio-demographic characteristics on CVD and CVD risk. LC measurement models were estimated first, followed by an auxiliary model conditional on LC variables. Continuous and binary outcomes were reported as mean differences (MD) and odds ratios (OR), respectively, with 95% confidence intervals (95%CI).Results: We included 283,172 participants who had data on CVD status (52.6% males). Clustering of multiple lifestyle risk behaviours (physically inactive, poor fruit & vegetable intake, high alcohol intake, and prolonged sitting) had a 3.29 mean increase in CVD risk relative to high alcohol intake. In addition, adults with three lifestyle risk behaviours (physically inactive, poor fruit & vegetable intake, and high alcohol intake) had 25.18 higher odds of having CVD than those with two lifestyle risk behaviours (physically inactive, and poor fruit and vegetable intake). Social deprivation, gender and age were also associated with CVD.Conclusion: Individuals' LC membership with two or more lifestyle risk behaviours had a determinantal effect on CVD. Interventions targeting multiple lifestyle behaviours and social circumstances should be prioritized to reduce CVD burden.