bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic yield of a multigene sequencing approach in children classified as idiopathic short stature
Authors: Andrade Nathalia Liberatoscioli Menezes , Funari Mariana Ferreira de Assis , Malaquias Alexsandra Christianne , Collett-Solberg Paulo Ferrez , Gomes Nathalia L R A , Scalco Renata , Dantas Naiara Castelo Branco , Rezende Raissa C , Tiburcio Angelica M F P , Souza Micheline A R , Freire Bruna L , Krepischi Ana C V , Longui Carlos Alberto , Lerario Antonio Marcondes , Arnhold Ivo J P , Jorge Alexander A L , Vasques Gabriela Andrade 
Published: November 2022

Objective
Most children with short stature remain without an etiologic diagnosis after extensive clinical and laboratory evaluation and are classified as idiopathic short stature (ISS). This study aimed to determine the diagnostic yield of a multigene analysis in children classified as ISS.

Design and methods
We selected 102 children with ISS and performed the genetic analysis as part of the initial investigation. We developed customized targeted panel sequencing, including all genes already implicated in the isolated short-stature phenotype. Rare and deleterious single nucleotide or copy number variants were assessed by bioinformatic tools.

Results
We identified 20 heterozygous pathogenic (P) or likely pathogenic (LP) genetic variants in 17 of 102 patients (diagnostic yield = 16.7%). Three patients had more than one P/LP genetic alteration. Most of the findings were in genes associated with the growth plate differentiation: IHH (n  = 4), SHOX (n  = 3), FGFR3 (n  = 2), NPR2 (n  = 2), ACAN (n  = 2), and COL2A1 (n  = 1) or involved in the RAS/MAPK pathway: NF1 (n  = 2), PTPN11 (n  = 1), CBL (n  = 1), and BRAF (n  = 1). None of these patients had clinical findings to guide a candidate gene approach. The diagnostic yield was higher among children with severe short stature (35% vs 12.2% for height SDS ≤ or > −3; P = 0.034). The genetic diagnosis had an impact on clinical management for four children.

Conclusion
A multigene sequencing approach can determine the genetic etiology of short stature in up to one in six children with ISS, removing the term idiopathic from their clinical classification.
Trends in Suicidal Ideation-Related Emergency Department Visits for Youth in Illinois: 2016–2021
Authors: Brewer Audrey G. , Doss William , Sheehan Karen M. , Davis Matthew M. , Feinglass Joseph M. 
Published: November 2022

BACKGROUND AND OBJECTIVES
Increasing suicide rates and emergency department (ED) mental health visits reflect deteriorating mental health among American youth. This population-based study analyzes trends in ED visits for suicidal ideation (SI) before and during the coronavirus disease 2019 (COVID-19) pandemic.

METHODS
We analyzed Illinois hospital administrative data for ED visits coded for SI from January 2016 to June 2021 for youth aged 5 to 19 years. We characterized trends in patient sociodemographic and clinical characteristics, comparing three equal 22 month periods and analyzed patient and hospital characteristics associated with the likelihood of hospitalization.

RESULTS
There were 81 051 ED visits coded for SI at 205 Illinois hospitals; 24.6% resulted in hospitalization. SI visits accounted for $785 million in charges and 145 160 hospital days over 66 months. ED SI visits increased 59% from 2016 through 2017 to 2019 through 2021, with a corresponding increase from 34.6% to 44.3% of SI principal diagnosis visits (both P &lt; .001). Hospitalizations increased 57% between prepandemic fall 2019 and fall 2020 (P = .003). After controlling for demographic and clinical characteristics, youth were 84% less likely to be hospitalized if SI was their principal diagnosis and were more likely hospitalized if coded for severe mental illness, substance use, anxiety, or depression, or had ED visits to children’s or behavioral health hospitals.

CONCLUSIONS
This study documents child ED SI visits in Illinois spiked in 2019, with an additional surge in hospitalizations during the pandemic. Rapidly rising hospital use may reflect worsening mental illness and continued difficulty in accessing low cost, high-quality outpatient mental health services.
Miniature mechanical testing of LMD-fabricated compositionally & microstructurally graded γ titanium aluminides
Authors: Galgon Florian , Melzer Daniel , Zenk Christopher , Džugan Jan , Körner Carolin 
Published: November 2022

AbstractThe design freedom in Laser Metal Deposition provided by the absence of a powder bed enables the fabrication of Functionally Graded Materials through Additive Manufacturing. For the first time, two suitable γ-TiAl alloys (TiAl48Cr2Nb2, TiAl45Nb4C) are combined in direct and gradual transitions to generate different microstructure morphologies and, consequently, different mechanical properties within a component after an identical heat treatment. The influence of alloy composition, microstructure type, and material transition on the tensile properties and fracture toughness is analyzed through miniature testing. Miniature tensile tests show no orientation dependency in regard to the build direction and the composition/microstructure transition is not found to be a preferred fracture site. The miniature fracture toughness tests reveal that already small composition changes—insufficient to alter the microstructure configuration—can have a significant effect on the cracking behavior.

Graphical abstract
Development technology of functional soft ice cream using beet pectin concentrate and probiotic
Authors: Zhexenbay Nurshash , Kizatova Maigul , Nabiyeva Zhanar , Iskakova Galiya , Grynchenko Nataliya , Foshchan Andriy , Grinchenko Olga 
Published: November 2022

Technology of soft ice cream has been developed using beet pectin concentrate (BPC) as a functional component. As an additional component of the probiotic action, the probiotic Bifidobacterium, Lactobacillus were introduced in an amount of 0.1 %. The regularities of the influence of BPC on the density and viscosity of prescription mixtures, whipping and resistance to melting of soft ice cream have been established.
With the introduction of more than 10.0 % of BPC, milk proteins coagulated, the texture of the prescription mixture was characterized by heterogeneity, a slight detachment of the aqueous phase was observed; soft ice cream had a slightly flaky texture.
The quality indicators of soft ice cream with different fat content (plombir –14.0 %, creamy – 11.6 %) with the addition of pectin concentrate and probiotic Bifidobacterium + Lactobacillus were studied. Soft ice cream is characterized by high nutritional value (the mass fraction of protein is 2.6–3.2 %, milk fat – 11.0–14.0 %, sucrose – 11.2–11.7 %), contains water-soluble vitamins and pectin (0.5–1.0 %), which is a natural enterosorbent.
The development of technology for the soft use of BPC allows expanding the range of food products enriched with functional ingredients. The introduction of probiotic improves the physiological functionality of the product, in particular, improves the functioning of the gastrointestinal tract
Influence of the mold type on the mechanical properties of the piston alloy with nano alumina in casting and metal mold
Authors: Al-Zuhairi Haitham Mohammed Ibrahim , Alshalal Iqbal , Abtan Auday Awad , Mahdi Baha Sami , Asmail Muna Khalil 
Published: November 2022

This research is an experimental comparison study to show the influence of mold type casting on mechanical properties. The study considers the aluminum alloy of a gasoline engine piston with nanoparticles alumina Al2O3 size 25 nm manufactured in two types of molds. Sand mold and cast-iron mold were selected to cast the aluminum composite components. A systematic comparative study of tensile strength and hardness properties of cast aluminum components is made on sand and metal molds production. The nano powder can add to enhance the mechanical properties must not exceed 4 % for metal and sand mold casting. According to data for hardness, adding nano alumina powder has minimal impact on metal mold casting, but it significantly improves sand casting. From a financial standpoint, metal casting provides higher economic values for making piston aluminum castings. The hardness rises as the alumina content does in two molds as compared to the obtained specimen. It demonstrates that the highest hardness occurs at 4 % alumina in the sand-casting mold and at 6 % alumina in the metal. When the compositions of the casting materials are the same, a comparison of the fracture morphology between sand and mold casting reveals more ductile fractures for metal molds compared to brittle fractures in sand cast by large silicon separation grains because of higher grain growth in sand casting by longer solidification time. The same is seen in mold casting, which exhibits reduced ductility due to the alumina nanoparticles' dispersion strengthening process in the aluminum matrix. This arises as a result of nano alumina dispersion acting as barriers to dislocation motions in the aluminum matrix, enhancing strength but reducing ductility.
From Homo Habllis to Homo Sapiens and Back
Authors: Крюковский А.С. , Палкин Е.А. 
Published: November 2022

Рассматривается вопрос о принципиальных различиях в организации образовательного процесса в высшем учебном заведении на базе компетентностного подхода и на основе структурирования дидактики высшего образования. На основе федерального образовательного стандарта бакалавриата по направлению подготовки 09.03.01 «Информатика и вычислительная техника» демонстрируется несостоятельность реализации целевых установок по приобретению обучающимися профессиональных компетенций программиста. В рамках концепции приоритета знаний предлагается решать вопрос о формах и сроках освоения программ на основе необходимых объемов дидактического материала, подлежащего усвоению в процессе обучения.
The problem of fundamental diff erences in the educational process organization in a higher educational institution on the basis of a competence-based approach and on the basis of structuring the didactics of higher education is considered. On the basis of the Federal State Educational Standard for bachelor’s degree in the fi eld of training 09.03.01 «Computer Science and Computer Engineering», the inconsistency of the implementation of targets for the acquisition of professional programmer competencies by students is demonstrated. Within the framework of the of the knowledges priority concept, it is proposed to solve the question of the forms and timing of the educational programs development on the basis of the necessary volumes of didactic material to be mastered in the learning process.
Historical and Pedagogical Analysis of the Formation of Pedago­gical ldeas about the Development of Physical Culture and Sports
Authors: Смирнов В.В. 
Published: November 2022

Рассмотрены педагогические идеи о развитии физической культуры и спорта, представленные в трудах политических и общественных деятелей, педагогов. Охарактеризована степень изученности данной проблемы, обоснован научный интерес к ней педагогического сообщества. Выделены этапы развития физической культуры и спорта в истории нашей страны, их основные характеристики, эволюция идей о роли и значении физической культуры, направленности физического воспитания подрастающих поколений.
Pedagogical ideas about the development of physical culture and sports presented in the works of political and public fi gures, teachers are considered. The degree of study of this problem is characterized, the scientifi c interest of the pedagogical community in it is justifi ed. The stages of the development of physical culture and sports in the history of our country, their main characteristics, the evolution of ideas about the role and importance of physical culture, the orientation of physical education of younger generations are highlighted.
A method of constructing a structurally redundant information and telecommunication network that implements the triad principle of its construction
Authors: Лукин К.И. , Сагдеев А.К. , Стахеев И.Г. , Титова О.В. 
Published: November 2022

Информационно-телекоммуникационная сеть относится к классу больших систем, которые не могут быть созданы за короткое время и предполагают фрагментарное развитие. По этой причине методология должна включать не только методы синтеза, алгоритмической и параметрической оптимизации, но и методы инженерного проектирования. С этой целью в статье рассматривается методика реализации структурно-топологических принципов обеспечения устойчивости при построении сети, реализующая триадный принцип ее построения.
The information and telecommunication network belongs to the class of large systems that cannot be created in a short time and assume fragmentary development. For this reason, the methodology should include not only synthesis methods, algorithmic and parametric optimization methods, but also engineering design methods. To this end, the article discusses a methodology for implementing structural and topological principles of ensuring stability in the construction of a network, implementing the triad principle of its construction.
On the reduction of accepted alternatives in the management decision-making process
Authors: Клименко И.С. , Палкин Е.А. 
Published: November 2022

На базе принципа дополнительности Бора рассмотрена аналогия между коллапсом волновой функции квантовой системы и редукцией альтернатив в момент выбора управленческого решения. Обсуждены особенности использования взаимно дополнительных понятий при выборе решений, связанные с наличием у лица, принимающего решение, цели управления. Обращено внимание на тот факт, что к моменту перехода от размышлений к волевому акту управляющего воздействия ситуация принятия решения может быть формально представлена в виде суперпозиции альтернатив, а в качестве «измеряемой» выступает единственная выбранная альтернатива. В рамках принципа дополнительности сформулировано положение, согласно которому нахождение предпочтительной альтернативы и ее реализация посредством соответствующего управляющего воздействия аналогично действию измерения на квантовый объект.
On the basis of Bohr’s complementarity principle, the analogy between the collapse of the wave function of the quantum system and the reduction of alternatives at the moment of choosing a managerial solution has been considered. The features of the use of mutually additional concepts in the choice of decisions, connected with the presence of the decision-maker goal of management, were discussed. Attention is drawn to the fact that at the moment of transition from thinking to volitional act of controlling influence the state of decision-making situation can be formally presented in the form of a superposition of alternatives, and as «measured» is the only chosen alternative. Within the framework of the complementarity principle, it is stated that the finding of the preferred alternative and its realization through appropriate control action is similar to the action of the measurement on the quantum object.
Algorithmic and software support of the subsystem for automated evaluation of the effectiveness of training on the simulator complex
Authors: Полевщиков И.С. , Таланов А.А. 
Published: November 2022

Представлены результаты развития исследований в области разработки математического и программного обеспечения компьютерных тренажерных комплексов для автоматизированной оценки эффективности обучения операторов. Разработана усовершенствованная методика для оценки эффективности различных подходов и технологий обучения на компьютерных тренажерных комплексах с применением методов математической статистики. Методика учитывает комплексное оценивание результатов обучения и более проста в практическом использовании. Применение методики позволит повысить точность и снизить трудоемкость процесса оценки эффективности. Реализован прототип подсистемы компьютерных тренажерных комплексов для оценки эффективности в форме веб-приложения, применение которого позволяет осуществлять гибкую настройку необходимых исходных данных для оценивания, автоматически вычислять требуемые параметры на основе этих данных, структурированно хранить и представлять результаты оценивания для дальнейшего принятия решений специалистом.
The results of the development of research in the field of development of mathematical and software for computer training systems for automated evaluation of the effectiveness of operator training are presented. An improved methodology has been developed for evaluating the effectiveness of various approaches and technologies of teaching at computer training systems using the methods of mathematical statistics. The methodology takes into account the comprehensive assessment of learning outcomes and is easier to use in practice. The application of the methodology will improve the accuracy and reduce the complexity of the efficiency assessment process. A prototype of the computer training systems subsystem for performance evaluation has been implemented in the form of a web application, the use of which allows flexible configuration of the necessary initial data for evaluation, automatic calculation of the required parameters based on these data, structured storage and presentation of evaluation results for further decision-making by a specialist.
Clinical, demographic characteristics, and treatment protocols of optic neuropathies: Three-year follow-up experiences from a tertiary hospital in Turkey
Authors: Kandeger Burcu Taskiran , Tok Ozlem , Tok Levent 
Published: November 2022

Background: This study was conducted to review the demographic and clinical characteristics, treatment protocols, and visual outcomes of patients with optic neuropathy.
Methods: This historical cohort study analyzed the clinical features of 91 patients with optic neuropathy followed up for three years at a university hospital in Turkey.
Results: Non-arteritic anterior ischemic optic neuropathy (NA-AION) was the most common group among the optic neuropathy subgroups (47.2%), and optic neuritis (ON) was the second most common group (38.5%). The mean age of symptom onset for NA-AION was 64.97 ± 12.15 years, significantly higher than the mean age of onset for ON (40.28 ± 15.52 years). Most of the patients with NA-AION had at least one systemic disease causing microangiopathy [51.1% had diabetes mellitus (DM), 33.3% had hypertension (HTN)]. Among the patients with ON, 51.4% were idiopathic, and 25.7% were multiple sclerosis (MS)-related ON cases. Patients with ischemic optic neuropathy (ION), ON, and traumatic optic neuropathy received pulse intravenous (IV) corticosteroids, and eleven patients with NA-AION received acetylsalicylic acid (ASA) therapy in addition to corticosteroids. There was a statistically significant increase in visual acuity in NA-AION and ON groups (P = 0.019). It was observed that the cases of ON peaked in the winter months in Turkey.
Conclusion: In the differential diagnosis between NA-AION and idiopathic ON, the presence of one or more vascular systemic diseases and mean age may be the main factors. IV steroid treatment given to patients with NA-AION in the acute phase may significantly improve visual acuity.
A IMPORTÂNCIA DA QUALIDADE DE VIDA NO CONTROLE DA SOP
Authors: Bilésimo da Silva Gava Aline 
Published: November 2022

RESUMO: A Síndrome dos Ovários Policísticos (SOP),é uma desordem genética, multigênica, hormonal na qual afeta as mulheres em idade reprodutiva. Por ser um assunto de pouca abordagem nas conversas no meio de saúde, é de suma importância os trabalhos de educação em saúde e a promoção de saúde para esta síndrome. Este artigo de revisão bibliográfica tem como objetivo, apresentar as principais causas da SOP, como ela pode estar sendo controlada com uma alimentação adequada para cada indivíduo, a modo de facilitar a vida das portadoras. Essa revisão foi realizada com buscas de artigos científicos recentes a partir do ano de 2006 e anos mais atuais, encontrados em site de base de dados do Scielo, Lilac, Google Acadêmico. Este artigo também poderá ser utilizado como parâmetro na elaboração de artigos para outras revistas. Com isso, espera-se facilitar a vida das mulheres portadoras da SOP, a fim de que busquem cada vez mais, uma melhor qualidade de vida, com saúde, mantendo-a sobre controle, através de uma alimentação saudável, consequentemente diminuindo os sintomas indesejadose provocados pela doença.
Role of Innovation for Sustainable Development in Agriculture: A Review
Authors: Vyas Saurav , Singh Sukhjinder 
Published: November 2022

Modern agriculture is mainly concerned with enhancing output as well as quality improvement. This paper examines current thinking of agricultural improvements through innovations, what forms it takes, involvement of stakeholders and the social economic benefits derived. Rather than adopting newly developed technologies, agricultural advances frequently include the adaptation of existing updated technologies. Sustainable development is the process of meeting human needs and improving living conditions without endangering natural resources. It is a philosophy that tries to address human needs while simultaneously protecting the natural system. Economic growth, human development and ecological sustainability are all part of the sustainable development philosophy. Various research articles have been studied for current study which highlights the importance of innovation in agriculture and its benefits. The policy ecosystem of agriculture in India under the National Mission for Sustainable Agriculture as well as future prospects and solutions for India are also highlighted. We have found that there is a need to look at the potential barriers while implementing sustainable agriculture practice and the options for overcoming or minimising these barriers.
Alteration in amino acid composition of natural solid bitumens and some synthesized carbonaceous materials in the carbonization sequence
Authors: Shanina S. , Golubev E. , Amosova O 
Published: November 2022

Amino acids are important records of geochemical processes in sedimentary rocks. The knowledge about changing the composition of amino acids is important for our understanding of genetics of organic compounds in the geological records. In the presented work, compositions of amino acids in natural solid bitumens, graphites and some synthesized carbonaceous materials were investigated. We determined that the content of amino acids decreases with increasing temperature of the formation of natural carbonaceous substances. the content of aliphatic amino acids gradually increases with increasing degree of transformation in the carbonization (dehydrogenation) series, mainly due to glycine, alanine and leucine. The revealed changes in the amino acid composition of natural carbonaceous substances are associated with the genesis of the initial organic matter, as with as the content of carbonaceous matter and its interaction with the mineral component.
We showed that the selection of dominant individual amino acids without involvement of statistical methods did not allow distinguishing some types of natural carbonaceous materials. At the same time, lots of amino acids were identified by statistical methods, statistically significantly distinguishing all the studied types of solid natural bitumen and graphite.