bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of a web-based pre-intubation preparation module on the knowledge, skills and behavior of critical care fellows.
Authors: Alroumi Fahad , Dinino Ernest , Tidswell Mark , Blanchard Rebecca , Shatzer John 
Published: June 2022

Abstract
Background: It is a priority to have critical care trainees acquire competency in pre-intubation airway assessment and preparation. We describe the design, implementation, and evaluation of a novel web-based training module on critical care fellows’ ability to assess, predict and prepare for tracheal intubation. Methods: A needs assessment from fellows and from faculty found that structured training on intubation preparation and airway risk assessment was essential. We therefore designed an online module that combines mandatory readings, brief lectures and a case-based virtual activity. In addition to learner satisfaction, the outcome constructs of this module include improvements in fellows’ pre-intubation preparation assessment knowledge, skills, safety-oriented behaviors. Paired t-test was used to compare knowledge assessment scores pre and post module. Chi-square test was used to compare pre and post data for the categorical variables in the evaluation of the skill and behavior constructs. Results: All trainees (N=14) completed the module, and they were satisfied with its contents and structure. The mean score on the knowledge assessment increased significantly (from 79.9% to 90.3%, p =0.02). There was a total of 290 intubations logged by the fellows during the study period. First pass success did not significantly change after the module (88.6% vs 94.3%, p=0.89). There was a significant change in procedural note documentation to include at least one airway risk parameter in the fellow authored notes (65.9% vs 72.9%, P=0.049). All respondents were confident that they will be able to apply what they have learned in the module into clinical practice and that their patients will benefit from their new knowledge. Conclusion: The implementation of an asynchronous web-based module on airway assessment and intubation preparation was feasible. The module was engaging, enhanced knowledge of our trainees and improved procedural documentation.
Safety and short-term efficacy of gastrectomy after preoperative chemotherapy plus immunotherapy versus preoperative chemotherapy: A retrospective cohort study
Authors: Lei Xiaokang , Wang Yinkui , Shan Fei , Li Shuangxi , Jia Yongning , Miao Rulin , Xue Kan , Li Zhemin , Ji Jiafu , Li Ziyu 
Published: June 2022

Abstract
Purpose This study was conducted to compare the safety and short-term efficacy of gastrectomy after preoperative chemotherapy plus immunotherapy (PCIT) versus preoperative chemotherapy (PCT) in patients with advanced gastric cancer (AGC).Methods We retrospectively reviewed the data of patients with AGC who received PCIT or PCT at Peking University Cancer Hospital and Institute Gastrointestinal Cancer Center I between January 2019 and June 2021. The clinical characteristics were recorded, and short-term oncological outcomes were compared. Independent t-tests, Mann-Whitney U tests, Chi-square tests, and Fisher’s exact tests were used to calculate differences. The correlation analyses were performed using Pearson correlation. All p values were two-sided, and a p-value <0.05 was considered as statistically significant. All the above statistical analyses were conducted by the SPSS version 24.0 software package (IBM Corp., Armonk, NY, USA).Results A total of 162 AGC patients were included in this study, including 25 patients receiving PCIT and 137 patients receiving PCT. There were no significant differences in preoperative treatment-related adverse events (TRAEs) between the PCIT group and the PCT group (p=0.088). Compared with the PCT group, the PCIT group had comparable postoperative functional recovery, with no significant differences in terms of the first aerofluxus time (p=0.349), the first defecating time (p=0.800), the first time on liquid diets (p=0.233), and length of stay (p=0.278). No significant differences were observed in terms of postoperative complications (p=0.952), postoperative pain intensity at 24, 48, and 72 hours (p=0.375, p=0.601, and p=0.821, respectively), and postoperative supplementary analgesic between the two groups (p=0.881). In addition, the postoperative complication rates were 33.3% following the laparoscopic approaches and 31.2% following the open approaches in the PCIT group, with no significant difference (p=1.000).Conclusions In patients with AGC, gastrectomy with D2 or D2+ lymphadenectomy after PCIT was comparable to PCT in terms of short-term oncological outcomes. The safety of LG was similar to that of OG in patients with AGC after PCIT.
Fatigue status quo of children and adolescents with inflammatory bowel disease and its influencing factors in China: a cross-sectional study
Authors: Cao Jinjin , Wang Yuanyuan , Huang Yan , Ren Lei , Li Mei 
Published: June 2022

Abstract
Background: In recent years, the global diagnosis rate of inflammatory bowel disease of children and adolescents has been increasing. Fatigue was found to be the most exhausting symptom in inactive disease and the second most exhausting symptom in active disease. However, little is known about fatigue in pediatric inflammatory bowel disease. Hence, the aim of this study is to investigate the prevalence and status of fatigue in a cohort of pediatric inflammatory bowel disease patients in China.Methods: A cross-sectional, questionnaire-based survey was conducted. The researchers recruited convenience samples of patients with inflammatory bowel disease from Department of Gastroenterology of a children’s hospital located in Nanjing, China. The prevalence and status of fatigue were measured by a questionnaire, and associations potential factors were examined using multiple regression analysis.Results: The total score of fatigue in children with inflammatory bowel disease was 62.22±20.55. The results of univariate analysis of fatigue degree in patients with inflammatory bowel disease showed a significant difference among regions, age, disease severity, corticosteroids and biological agents (p< 0.05).Conclusions: Fatigue was a multidimensional symptom, and most pediatric patients with inflammatory bowel disease were distressed by fatigue symptom. The patient’s region, age, disease severity, BMI and drug use were the significant predictors of fatigue. Health care providers should pay attention to the patient’s fatigue symptom. After the initial assessment of the patient’s fatigue, the targeted interventions should given to improve the symptom.
Dietary and Pharmacological Management of Plasma Glucose, Triglyceride and Glycated Hemoglobin among Patients with Type 2 Diabetes Mellitus
Authors: Natour Nihal , Bakri Fatma , Al-Tell Mariam , Shaheen Amera 
Published: June 2022

Abstract
Introduction: Diabetes mellitus type 2 (DM2) is among leading causes of mortality in Occupied Palestinian territories and providing data on its level of management using pharmacological and dietary approaches is important to provide policy makers of possible gaps in clinical practice.Aims: we aimed to study the level of control of recently diagnosed patients with DM2 and patterns of pharmacological treatment and dietary intakes in relation to clinical endpoints.Methods: we used semi-structured questionnaire, medical records, anthropometric measurements and biochemical measurements to assess plasma glucose, Glycated hemoglobin (HbA1C), medical and medication history, measurement of obesityResults105 participants were included in this analysis with few missing data for some sub-analysis. Average age was (56.8 ± 8.1 y), medians for glucose (160 (150, 180)mg/dl ), Triglyceride (TG (155 (140, 170) mg/dL ), HbA1C (8 (7, 9)%). Metformin was associated with best HbA1C control compared to groups who used insulin (p< 0.01). Also, HbA1C and glucose were different across fish intake categories. Nuts were associated with modest improvement in HbA1C. Plasma TG was not modified by study variables.ConclusionMetformin, fish intake and nuts intake were associated with improvement in glucose and HbA1C among diabetic patient in Palestinian territories.
Changes in social behavioral developmental risks in preschool children after the first COVID-19 wave – results from a prospective cohort study
Authors: Kästner Anika , Ernst Vanessa Sophie , Hoffmann Wolfgang , Franze Marco 
Published: June 2022

Abstract
Since the outbreak of the COVID-19 pandemic, in many countries preschool and school closures were common, especially at the beginning of the pandemic. The impact of the pandemic on developmental risks in the social-emotional domain of preschool children is largely unknown. In this prospective dynamic cohort study social behavioral developmental risks were longitudinally assessed with the “Dortmund Developmental Screening for Preschools (DESK 3-6 R)”. Therefore, DESK 3-6-R data from 3-year-olds at survey wave 3 (DESK-R-SW3, 2019) and 4-year-olds at survey wave 4 (DESK-R-SW4, 2020) were used. In addition, data assessed in previous survey waves were analyzed to contextualize the observed changes. A total of N=786 children were included in the analysis. In DESK-R-SW3 the proportion of children with social behavioral developmental risks/inconclusive findings was 18.2%, whereas in DESK-R-SW4 the proportion decreased to 12.4%. The prevalence rate ratio (PRR) was therefore 0.68 (p=0.001). Compared to data from the previous survey waves (PRR=0.82; PRR=0.88), this result represents a notable improvement. No deteriorations in the prevalence of preschoolers’ social behavioral development risks after the first COVID-19 wave could be observed. The results are discussed in the framework of the pandemic situation in the study region and the current literature.
Interaction between a screw dislocation and an elastic elliptical inhomogeneity by using the angular basis function
Authors: Chen J.-T. , Lee J. W. , Kao S. K. 
Published: June 2022

Abstract
The behavior of displacement field due to a screw dislocation is similar to the angular basis function (ABF) Arg(z). It is different from the radial basis function (RBF) ln(r) that is used to describe the velocity potential of a sink or source. Nevertheless, the complex-valued fundamental solution ln(z) contains the two parts of RBF ln(r) and ABF Arg(z). In this paper, not only the RBF in the null-field boundary integral equation (BIE) but also the ABF for the screw dislocation are employed to study the interaction between a screw dislocation and an elastic elliptical inhomogeneity. This problem is decomposed into a free field with a screw dislocation and a boundary value problem containing an elliptical inhomogeneity. The boundary value problem is solved by using the RBF and the null-field BIE. Since the geometric shape is an ellipse, the degenerate kernel is expanded to a series form under the elliptical coordinates, while the unknown boundary densities are expanded to eigenfunctions. By combining the degenerate kernel and the null-field BIE, the boundary value problem can be easily solved. The inconsistency between Sendeckyj [1] and Gong & Meguid [2] for the problem was also found by using the present approach. The error in [2] was also printed out. Finally, some examples are demonstrated to verify the validity of the present approach.
Complete response of RCC to autologous T cell immunotherapy following progression on immune checkpoint inhibitor, A case report
Authors: Ren Jun , Wu Tiecheng , li Congcong , Wang Xiaoli , Hu Lina , Zhou Xinna , Bao Xuhui , Wan Kun , Zeng Chuxiong , Sun Bo , Lou JingJing , Liu Xingdang , Hobeika Amy , Morse Michael A. , Lyerly Herbert Kim 
Published: June 2022

Abstract
Background: The renal clear cell carcinoma (RCCC) is a frequent occurrence of kidney cancer, such tumor was concealed progressed until symptomatic developed or through imaging examination. More recently, targeted therapies, immunotherapy and their combinations have improved outcome .However seeking the novel salvage treatment of second-line or above of post-immunotherapy has been warranted.Case presentation: A 55-year-old man diagnosed with non-VHL associated renal clear cell carcinoma presented 8 years ago. The upper abdominal distention and hematochezia were noticed after 6 years of nephrectomy, surgically confirmed pancreas-duodenal metastatic lesions 1.5 years ago to preclude the second primary carcinoma. Despite eight cycles of pembrolizumab plus axitinib after surgery, liver multiple masses progress rapidly. Following four cycles of autologous adoptive T cell immunotherapy and hyperthermia with low dose pembrolizumab, all metastatic lesions demonstrated complete responses. No serious adverse events were reported.Conclusions: This triple combination of adoptive T cell therapy, low dose immune checkpoint blockade, and hyperthermia has been salvage treatment for RCCC.
The impact of thickness heterogeneity on soft tissue biomechanics: A novel measurement technique and a demonstration on heart valve tissue
Authors: Lin Chien-Yu , Mathur Mrudang , Malinowski Marcin , Timek Tomasz A. , Rausch Manuel K. 
Published: June 2022

Abstract
The mechanical properties of soft tissues are driven by their complex, heterogeneous composition and structure. Interestingly, studies of soft tissue biomechanics often ignore spatial heterogeneity. In our work, we are therefore interested in exploring the impact of tissue heterogeneity on the mechanical properties of soft tissues. Therein, we specifically focus on soft tissue heterogeneity arising from spatially-varying thickness. To this end, our first goal is to develop a non-destructive measurement technique that has a high spatial resolution, provides continuous thickness maps, and is fast. Our secondary goal is to demonstrate that including spatial variation in thickness is important to the accuracy of biomechanical analyses. To this end, we use mitral valve leaflet tissue as our model system. To attain our first goal, we identify a soft tissue-specific contrast protocol that enables thickness measurements using a Keyence profilometer. We also show that this protocol does not affect our tissues' mechanical properties. To attain our second goal, we conduct virtual biaxial, bending, and buckling tests on our model tissue both ignoring and considering spatial variation in thickness. Thereby, we show that the assumption of average, homogeneous thickness distributions significantly alters the results of biomechanical analyses when compared to including true, spatially-varying thickness distributions. In conclusion, our work provides a novel measurement technique that can capture continuous thickness maps non-invasively, at high resolution, and in short time. Our work also demonstrates the importance of including heterogeneous thickness in biomechanical analyses of soft tissues.
Proposed introduction of the SBAR method in rehabilitation
Authors: Tedeschi Roberto , Betti Fabio 
Published: June 2022

Abstract
This project aims to implement within the Rehabilitation Operative Unit of the Ausl of Bologna the standardised SBAR (Situation-Background-Assessment-Recommendation) method for the transfer of information between physiotherapists, in order to improve the safety of the care pathway. This project, promoted by the DATeR Direction of the Ausl of Bologna (Technical and Rehabilitation Assistance Direction), is characterised by the insertion of the SBAR form within some of the company's care units. Professional physiotherapists from some of the Care Units under the Rehabilitation Operational Unit were involved. The rehabilitation SBAR card was introduced in the Care Units involved in the following 6 months. The implementation phase was characterised both by the use of the tool and by periodic peer-to-peer meetings which animated discussions and comparisons on the specific contents concerning the card. Monthly sample checks were carried out on some completed SBAR forms to monitor their correct filling in. Finally, the opinion of all the physiotherapists of the 4 Care Units was surveyed through the administration of a semi-structured questionnaire. The SBAR rehabilitation form was therefore officially implemented from January 2020 in the 4 Care Units involved in the project. A further improvement project is planned to implement the use of the rehabilitation SBAR card in the entire Rehabilitation Unit.
Evaluation of a new performance-based, disease-specific health literacy measurement tool for patients with chronic airways diseases: the Vancouver Airways Health Literacy Tool (VAHLT)
Authors: Poureslami Iraj , Kopec Jacek A. , Sawatzky Rick , Hohn Ric , Aaron Shawn D. , Gupta Samir , Goldstein Roger , Lavoie Kim L. , Boulet Louis-Philippe , Tregobov Noah , Shum Jessica 
Published: June 2022

Abstract
Background: Low health literacy (HL) is a global challenge. HL is positively correlated with chronic airways disease (CAD) outcomes. Despite the importance of HL in disease management, current HL measurement tools are suboptimal. As part of a multi-stage project to develop a performance-based, disease-specific Vancouver Airways Health Literacy Tool (VAHLT) for patients with CAD, this study assessed the relationships between VAHLT scores and CAD patient characteristics. The primary aim of the study is to provide preliminary evidence of construct validity of the VAHLT. Methods: A cross-sectional study design was applied. Patients were recruited from 6 specialty care clinics to complete the measurement tool. Demographic and clinical data, including quality of life (QOL) and disease control, were collected via validated questionnaires. Subjects also completed spirometry. Inferential analysis was conducted using mean difference testing and correlational methods. Results: 320 patients were recruited, and after imputing missing data, 315 were ultimately analyzed. Participants were predominantly female (60.5%), Caucasian (83.1%), had post high-school education (74.2%), with a mean age of 65.2 (SD = 13.17) years. Age was significantly negatively correlated with HL scores (p = .004); patients with post-high school education had significantly higher HL scores than those with a high school education or less (p < .001). No significant sex or ethnicity related differences in HL scores were observed. For clinical outcomes, no significant differences were found between HL scores and disease severity or measures of QOL and asthma control. Conclusions: We report a CAD-specific HL measurement tool developed with involvement of patients and professionals. Age and education were highly correlated with HL, which emphasizes the importance of addressing these factors in HL interventions among CAD patients. In the next phase, we will evaluate the tool’s responsiveness to interventions.
Mapping and determinants of consumption of egg and/or flesh foods and zero vegetables or fruits among young children in SSA
Authors: Hailu Bayuh Asmamaw , Geremew Bisrat Misganew , Liverani Silvia , Abera Kindiye Setargie , Beyene Joseph , Miheretu Birhan Asmame 
Published: June 2022

Abstract
Zero vegetable or fruit and egg and/or flesh foods are the latest indicators for assessing infant and young child feeding practices. Understanding national and subnational heterogeneity and regional clustering in children with SSA is becoming increasingly essential for geographic targeting and policy prioritization. Geographical case identification, determinants, and impacts were all investigated. SSA children's consumption of vegetable or fruit, egg and/or flesh food, and both were low. In SSA, some portions of the Southern, South direction of the Western and Central regions have a lower weight of all bad conditions than others, although children continue to suffer in considerable numbers in all disadvantage circumstances. Children under the age of one year, from rural areas, uneducated families, and low income were all disadvantaged by both feeding techniques. To improve child nutrition status, multisectoral collaboration is essential. This framework allows for the tracking, planning, and implementation of nutritional treatments.
STUDI KRITIS PENDIDIKAN TOLERANSI DI INDONESIA
Authors: Anwar Ervan Choirul 
Published: June 2022

Indonesia. Pemetaan dalam pembahasan artikel ini meliputi tema-tema yang sering digunakan dalam penelitian sebelumnya dan implementasi pendidikan toleransi di Indonesia. Penelitian ini menggunakan metode kualitatif literature review dengan pendekatan Systematic Review. Pengumpulan data dilakukan menggunakan Google Schoolar dengan memasukkan kata kunci “Pendidikan Toleransi” dan terbatas pada artikel yang diterbitkan dalam lima tahun terakhir (2015-2020). Artikel tersebut kemudian diolah untuk memetakan tema-tema yang sering digunakan oleh peneliti sebelumnya. Kemudian dianalisis untuk mendapatkan gambaran tentang aspek fokus kajian, metode, dan model pelaksanaan pendidikan toleransi di Indonesia. Hasil pembahasan menunjukkan bahwa penelitian dengan topik pendidikan toleransi telah banyak dilakukan di sekolah dan pesantren. Kajian lebih banyak dilakukan dengan mengintegrasikan pendidikan toleransi dengan pendidikan agama. Sementara itu, penguatan pendidikan toleransi dengan nasionalisme atau kebangsaan masih kecil. Selain itu, topik pendidikan toleransi di masyarakat belum terlalu banyak dipelajari. Sementara itu, pelaksanaan pendidikan karakter di sekolah, pondok pesantren dan masyarakat dilakukan dengan menggunakan empat pendekatan. Pertama, integrasi pendidikan toleransi dengan pendidikan multikultural. Kedua, integrasi pendidikan toleransi dengan Pendidikan Agama Islam. Ketiga, integrasi pendidikan toleransi dengan pembelajaran. Keempat, suri tauladan kyai.

Kata Kunci : Pendidikan, Toleransi, Indonesia
Mn substitution and distribution in goethite and influences on its photocatalytic properties: A combined study using first-principles calculations and photocatalytic experiments
Authors: Liu Xin , Liu Huan , Zong Meirong , Chen Meng , He Hongping , Wang Rucheng , Lu Xiancai 
Published: June 2022

Abstract
Goethite and modified goethites have been found as good photocatalysts because their conduction band can mediate electron transfer in various redox processes. Many kinds of metal elements can be incorporated into the structure of goethite to form solid solutions in nature, but their optoelectronic properties have not been well disclosed. Mn-substituted goethite is one of the potential photocatalysts, which can exhibit high-photocatalytic activity in many Earth’s surface processes. Based on the first-principles calculation, pairwise interaction energies and static lattice energies of goethitegroutite solid solution were computed, and the most thermodynamically stable configurations of Mn-substituted goethite were determined. The results indicate that Mn3+ ion tends to distribute within the cation layer parallel to the (001) plane. Phase relations of goethite-groutite solid solution were derived by subsequent configurational statistics with energies of all 232 configurations of a 2 × 1 × 4 supercell with 32 exchangeable cations. The phase diagram shows that no more than 3 mol% Fe of goethite can be substituted by Mn ions. Therefore, Mn-substituted goethite is thermodynamically metastable or bears groutite-like clusters/lamellae. Furthermore, the effects of Mn substitutions on the band gap were experimentally and theoretically investigated. It is found that a small amount of Mn-substitution can reduce the band gap of goethite significantly, and the decrease ceases when the Mn content is higher than 3–4 mol%. Such a decrease in band gap causes red-shift to the photo response wavelength of goethite and improves the responding capability. This improvement was confirmed in the experiments of photocatalytic degradation of methylene blue (MB). Such kind of photocatalytic reaction probably can happen widely in natural environments. Therefore, the contribution of photocatalysis of natural goethites to geochemical processes on Earth’s surface should be considered.