bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatio-temporal analysis of East Asian seismic zones based on multifractal theory
Authors: Zhang Ziyan , Liu Guoyong , Chen Changjiang , Tian Jiawei , Liu Shan , Yin Lirong , Zheng Wenfeng 
Published: April 2022

Abstract
In this article, the integrity of the seismic catalog obtained (1970–2014, M > 2.8) was verified according to the Gutenberg–Richter relation, the appropriate minimum magnitude was determined, and the whole region was divided into five areas according to the geological structure background of the whole research object and the trend of the historical seismic zone. We applied multifractal analysis in each partition. The results showed that although in different geological backgrounds, before major earthquakes, the earthquake time series information dimension had different degrees of growth, and the parameter after the flame had different degrees of decline. To a certain extent, this reflected the seismic energy accumulation and release process. In addition, the variation of fractal parameters in scale-free regions of time series and spatial distribution series also indicated that these two kinds of sequences in different regions show the characteristics of a multifractal structure rather than a single and uniform fractal structure.
Guest editorial: Information security methodology and replication studies
Authors: Wendzel Steffen , Caviglione Luca , Mileva Aleksandra , Lalande Jean-Francois , Mazurczyk Wojciech 
Published: April 2022

Abstract
This special issue presents five articles that address the topic of replicability and scientific methodology in information security research, featuring two extended articles from the 2021 International Workshop on Information Security Methodology and Replication Studies (IWSMR). This special issue also comprises two distinguished dissertations.
lncRNA NONRATT013819.2 promotes transforming growth factor-β1-induced myofibroblastic transition of hepatic stellate cells by miR24-3p/lox
Authors: Guo Can-Jie , Pan Qin , Ma Xiong 
Published: April 2022

Abstract
Long noncoding RNAs (lncRNAs) are key regulators of hepatic stellate cells (HSCs), yet the role of upregulated lncRNA-NONRATT013819.2 in activated HSCs remains uncertain. In this study, the effects of NONRATT013819.2 on proliferation, apoptosis, migration, and contraction of transforming growth factor (TGF)-β1-induced HSCs were investigated. The mechanisms of NONRATT013819.2 on the activated HSCs were explored by loss-of-function of NONRATT013819.2 and gain-of-function of the target gene. Here, TGF-β1 treatment resulted in a gradual increase in the expression of cytoskeleton markers (collagen, α-SMA, and TIMP1), NONRATT013819.2, miR24-3p, and lysyl oxidase (Lox) over time in HSCs. NONRATT013819.2 acted as a sponge of miR24-3p to competitively abolish the inhibition of the lox gene in HSCs. Silencing of NONRATT013819.2 suppressed the expression of cytoskeleton markers, proliferation, and the proportion of cells that entered the S-phase, and promoted apoptosis in TGF-β1-activated HSCs. These effects were reversed when lox overexpression was introduced simultaneously. Similarly, silencing of NONRATT013819.2 also blocked ECM reconstruction, while recused by lox overexpression in TGF-β1-activated HSCs. In conclusion, upregulation of NONRATT013819.2 promotes the myofibroblastic transition by competitively binding miR24-3p to release lox in HSCs. Therefore, targeted therapy of NONRATT013819.2 may have the potential for liver fibrosis.
PRAKTIK DAKWAH ONLINE DI MEDIA SOSIAL (STUDI KASUS PADA AKUN INSTAGRAM @KHALIDBASALAMAHOFFICIAL)
Authors: Kulsum Umi , Subhan Arief , Darajat Deden Mauli 
Published: April 2022

Teknologi kerap dipandang negatif oleh kelompok agama karena dianggap bagian dari modernitas yang identik dengan sekularisme. Kehadiran praktik dakwah online di internet mematahkan anggapan ini. Dakwah online tidak sekedar sebagai ruang keberagamaan baru, namun juga mampu menunjukkan ekssitensinya sebagai gerakan sosial spiritual di ruang virtual. Salah satu praktik dakwah online yang memperoleh perhatian adalah akun dakwah kelompok Salafi @khalidbasalamahofficial. Studi ini ingin menjawab bagaimana praktik dakwah online pemuka agama dari kelompok Salafi di media sosial. Riset ini menggunakan perspektif religion online yang melihat bagaimana praktik agama di ruang nyata (offline) masuk kedalam ruang online. Menggunakan pendekatan kualitatif, metode etnografi virtual, dan model level analisis media siber. Hasil penelitian menunjukkan bahwa dalam praktik dakwah online terjadi proses modifikasi atas praktik dakwah konvensional di ruang nyata. Pelaku dakwah tidak hanya sekadar memindahkan kajian konvensionalnya ke ruang virtual, namun juga mengubah cara mereka dalam mengemas pesan dan meraih jamaah. Dalam praktik online ada proses yang terorganisir dan terstruktur baik dalam penentuan konten, penyajian, maupun dalam merespons jamaah yang lebih interaktif dibanding pada praktik dakwah konvensional yang terbatas. Meski demikian, keberadaan teknologi sebatas sebagai saluran baru, tanpa mengubah substansi nilai yang melekat pada ajaran Salafi. Selain itu, riset ini menunjukkan bahwa ruang online telah membuka sekat dan kebebasan jamaah untuk merespons isi dakwah secara terbuka dan langsung. Kata Kunci: praktik dakwah online, new media, salafi, instagram, akun @khalidbasalamahofficial
Evaluating the Impact of COVID-19 on a Regional Primary Percutaneous Coronary Intervention Service During the First Wave of COVID-19
Authors: Olusan Adeogo Akinwale , Devlin Peadar 
Published: April 2022

Background: Primary percutaneous coronary intervention (pPCI) is the preferred reperfusion strategy in ST-segment elevation MI (STEMI). This study evaluates the impact of COVID-19 on the authors’ pPCI service. Methods: A retrospective study of referrals to the Belfast pPCI service between 23 March and 9 June 2020 – the period of the first full lockdown in the UK – was performed. All ECGs were reviewed alongside patient history. A pPCI turndown was deemed inappropriate if the review demonstrated that the criteria to qualify for pPCI had been met. The number of pPCIs was compared with 2019. Results: The unit had 388 referrals in 78 days, from which 134 patients were accepted for pPCI and 235 referrals were turned down. Of these, nine (4%) were deemed inappropriate. No referrals were turned down because of COVID-19. Of the nine inappropriate cases, six had pPCI following re-referral, two had routine PCI and one had takotsubo syndrome. From the accepted cohort, 85% had pPCI. In the appropriate turndown cohort, there was a final cardiovascular diagnosis in 53% (n=127) of patients, 1-year mortality was 16% (n=38), 55% (n=21) of which were due to a cardiovascular death. There was a 29% reduction in the number of pPCIs performed compared with 2019. Conclusion: During the first wave of COVID-19 there was a significant reduction in the number of pPCIs performed at the Department of Cardiology at Royal Victoria Hospital in Belfast. This was not due to an increase in referrals being inappropriately turned down. The majority of the cohort who had their referral turned down had a final cardiovascular diagnosis unrelated to STEMI; 1-year mortality in this group was significant.
Iteration type I of holistic DBR - transferability of design Principles
Authors: Tammeleht Anu 
Published: April 2022

The iterative nature of DBR is a well-known and valued aspect of research in education. Nevertheless, iterations may take different formats, especially if a complex design object is at hand. Holistic DBR outlined by Dr Gabi Reinmann (2020) provides an opportunity to display development of complex research objects. Still, there are not many examples to illustrate holistic DBR iterations. The current paper illustrates iteration type I of the holistic DBR and also displays how transferability of design principles can be tested. The iteration is a part of a wider DBR (Cycle 10) outlined in the article: Design principles for developing online ethics resources - the outcome of holistic DBR process. The current study utilised document analysis and a short questionnaire to evaluate whether the design principles would support creating ethics resources in various disciplines. The results of Cycle 10 contributed to elaboration of design principles, and elicited recommendations on facilitation of ethics training.
Seferîlik Hükümleri Açısından Vatan Çeşitleri
Authors: ERDEM Abdullah 
Published: April 2022

İslam dini bütün konularda olduğu gibi yolculuğa çıkan kişiler için de birçok kolaylıklar sağlamıştır. Yolcular için sağlanan kolaylıklar diğer birçok meselede olduğu gibi fıkıh kitaplarımızda ayrıntılı bir şekilde anlatılmıştır. Bu kolaylıklar; dört rekâtlı namazların iki rekât olarak kılınması, ramazan ayında yolculuk yapılması halinde oruçların kazaya bırakılması, cuma ve bayram namazlarının vücûbiyetinin düşmesi, mestler üzerine mesh etme süresinin üç gün üç geceye çıkması ve memleketinde parası olsa bile ihtiyaç hâsıl olması halinde yolcunun zekât alabilmesi şeklinde özetlenebilir.
Bu kolaylıkların terettüp edebilmesi için yolculuğa çıkılacak yerin ve gidilecek yerin hangi şartları barındırması gerektiği bilinmelidir. Hanefîler genelde bir kişinin ikâmet ettiği yeri vatan-ı aslî ve vatan-ı ikâmet olarak belirlemiş ve seferîlik hükümlerinin bu iki yerden ayrılmak suretiyle tahakkuk edeceğini belirtmişlerdir. Diğer mezhep âlimleri de seferîliğin ikamet mahallinden çıkmakla terettüp edeceğini söylemektedirler. Ancak ikamete niyet etmenin gerekmesi veya gerekmemesi veya ikamet süresinin belli bir süreden kısa olması ve uzun olması gibi durumlarda iki mahallin birbirinden farklı hükümler içerdiği göz önünde bulundurulursa Hanefîlerin yaptığı taksimatın daha içinden çıkılabilir olduğu anlaşılır. Bu sebeple çalışmamızda Hanefîlere göre vatan çeşitleri işlenecek ve yeri geldikçe de diğer mezheplerin görüşlerine yer verilecektir.
İslam hukuku eserlerinde vatan çeşitleri genelde misafirin namazı başlığı altında işlenmiştir. Hanefîler namazların kısaltılıp kısaltılmaması açısından üç farklı mekân çeşidinden bahsetmişler; Maliki, Şâfiî ve Hanbeli mezhepleri ise daha çok namazın kısaltılabileceği ve kısaltılamayacağı yer şeklinde bir ayırıma gitmişler ve seferîlik konularını bu iki mekâna göre işlemişlerdir. Bununla birlikte Mâlikî, Şâfiî ve Hanbelîlere göre yolcunun namazı kısaltması daha faziletli olmakla birlikte bu zorunlu değildir. Hanefîlere göre ise yolculuk halinde namazların kısaltılması zorunludur. Bu sebeple nerelerde namazın kısaltılması gerektiği, nerelerde gerekmediği hususunu netleştirmek için vatan çeşitlerini bilmek önem arz etmektedir.
E-UKBM MODEL EKSPERIENTAL JELAJAH ALAM SEKITAR (EJAS) PADA MATERI PERUBAHAN LINGKUNGAN
Authors: Wardhani Yayang Setya , Al Muhdhar Mimien Henie Irawati , Prasetyo Triastono Imam , Sumberartha I Wayan 
Published: April 2022

Abstrak. Penelitian pengembangan dengan judul E-UKBM Model Eksperiental Jelajah Alam Sekitar (EJAS) Pada Materi Perubahan Lingkungan telah dilakukan pada bulan September 2019 sampai Maret 2020. Penelitian ini bertujuan untuk (1) Menguji kevalidan serta kepraktisan E-UKBM model Eksperiental Jelajah Alam Sekitar (EJAS) pada materi perubahan lingkungan. Produk E-UKBM yang dikembangkan dengan model pengembangan ADDIE. Model pembelajaran yang digunakan adalah Model Eksperiental Jelajah Alam Sekitar (EJAS). Subjek penelitian adalah 35 siswa kelas X MIPA B-2 SMAN 3 Malang. Hasil implementasi berupa data hasil validasi validator ahli dan data angket respon siswa sebagai pengguna E-UKBM. Hasil validasi E-UKBM oleh ahli media sebesar 97 persen (sangat valid), hasil validasi oleh ahli materi berupa hasil validasi butir soal dan komponen materi E-UKBM sebesar 100 persen (sangat valid). Hasil validasi oleh ahli perangkat pembelajaran dan praktisi lapangan berturut-turut menunjukkan bahwa E-UKBM sangat valid dengan persentase sebesar 97 persen dan 95 persen. Data kepraktisan setelah implementasi E-UKBM yakni sebesar 88 persen yang berarti sangat praktis untuk digunakan dalam pembelajaran. E-UKBM model Eksperiental Jelajah Alam Sekitar (EJAS) materi perubahan lingkungan yang dikembangkan telah memenuhi syarat kevalidan dan kepraktisan untuk digunakan dalam pembelajaran Biologi.Abstract. Development research with the title E-UKBM Experiential Model Exploration of the Environment (EJAS) on Environmental Change Materials has been carried out from September 2019 to March 2020. This study aims to (1) Test the validity and practicality of the E-UKBM Experiential Nature Exploration Model (EJAS). ) on the material of environmental change. E-UKBM product developed with the ADDIE development model. The learning model used is the Environmental Exploration Experimental Model (EJAS). The research subjects were 35 students of class X MIPA B-2 SMAN 3 Malang. The implementation results are in the form of expert validator validation data and student response questionnaire data as E-UKBM users. The results of the validation of E-UKBM by media experts are 97 percent (very valid), the results of validation by material experts in the form of validation results of questions and components of E-UKBM material are 100 percent (very valid). The results of validation by learning device experts and field practitioners respectively show that the E-UKBM is very valid with a percentage of 97 percent and 95 percent. The practicality data after the implementation of E-UKBM is 88 percent which means it is very practical to use in learning. The E-UKBM Experiential Exploration of the Environment (EJAS) model of environmental change material developed has met the validity and practicality requirements for use in Biology learning.
ANDROBIOCATION BERBASIS SCIENCE, ENVIRONMENT, TECHNOLOGY, SOCIETY, ISLAMIC INTEGRATION DAN HOTS (HIGHER ORDER THINKING SKILL) PADA MATERI SISTEM KOORDINASI
Authors: Ulfaa Irma , Hidayat Saifullah , Anggis Eka Vasia 
Published: April 2022

Abstrak. Tujuan dari pengembangan ini adalah untuk mengembangkan media pembelajaran androbiocation berbasis SETSI (Science, Environment, Technology, Society dan Islamic integrated) dan HOTS (Higher Order Thinking Skill) pada materi sistem koordinasi dan menguji kelayakan androbiocation yang telah dikembangkan. Metode yang digunakan untuk mengembangkan media pembelajaran androbiocation adalah Research and Development (R&D) dengan model ADDIE yaitu (Analyze, Design, Development, Implemetation dan Evaluation) yang dikembangkan oleh Robert M. Branch pada tahun 1975. pada penelitian ini menggunakan evaluasi formatif yaitu hasil penilaian terhadap media yang dilakukan setiap tahapnya sehingga dapat mengetahui kualitasnya. Hasil penelitian menunjukkan bahwa media pembelajaran androbiocation yang dibuat sangat layak dijadikan sebagai media pembelajaran. Penilaian media didasarkan para ahli dan peserta didik yakni ahli materi 85 persen (sangat layak) , ahli media 91 persen (sangat layak), ahli integrasi 100 persen (sangat layak), dan guru biologi 93 persen (sangat layak), serta terakhir peserta didik kelas XI SMA mendapat presentase 90 persen (sangat layak).Abstract. The purpose of this development is to develop androbiocation learning media based on SETSI (Science, Environment, Technology, Society and Islamic integrated) and HOTS (Higher Order Thinking Skill) in the coordination system material and test the feasibility of androbiocation that has been developed. The method used to develop androbiocation learning media is Research and Development (R&D) with the ADDIE model (Analyze, Design, Development, Implementation and Evaluation) which was developed by Robert M. Branch in 1975. In this study using formative evaluation, namely the results of the assessment of the media carried out at each stage so that they can know the quality. The results showed that the androbiocation learning media that was made was very suitable to be used as a learning medium. Media assessment is based on experts and students, namely material experts 85 percent (very decent), media experts 91 percent (very decent), integration experts 100 percent (very decent), and biology teachers 93 percent (very decent), and finally students’ class XI SMA gets a percentage of 90 percent (very decent).
Componentes socioculturales y ambientales que inciden en el ecoturismo comunitario
Authors: Vargas-Losada Heriberto Fernando , López de Parra Lillyam , Balanta-Martínez Victor Julio 
Published: April 2022

El ecoturismo tiene crecimiento constante en el mundo por el favorecimiento económico, conservación y protección del ambiente. El objetivo del artículo es analizar los componentes socioculturales y ambientales que inciden en el ecoturismo comunitario. Se realizó una exploración documental a partir de artículos, libros y capítulos de libro de la base de datos de citaciones y resúmenes Scopus, mediante la búsqueda de categorías: ecoturismo, relaciones y elementos. El periodo de consulta fue entre los años 2015 al 2021. Solo se consideraron los trabajos publicados en inglés, español y portugués, la muestra final fue de 98 documentos. Los resultados exponen las tendencias actuales de las investigaciones en ecoturismo comunitario: sus impactos positivos y negativos, elementos socioculturales en capital cultural y condiciones y estilos de vida; ambientales como capacidad de carga y educación ambiental; las relaciones con las políticas, tendencias de los lugares de producción como China y Malasia, y la tecnología implementada en servicios y productos. En conclusión, el ecoturismo es heterogéneo, busca equilibrio entre lo económico, ambiental y cultural. La participación comunitaria, gestión y planeación, educación ambiental, políticas de apoyo y TIC son esenciales.
A study on the safety profile and clinical outcomes in patients using tulobuterol transdermal patch as an add on therapy in stable chronic obstructive pulmonary disease
Authors: R Radhika , Thomas Beena , Rafad Ahmed , James Jerin , Chenthiyethu Mekha Monsi , Lal Ruben Thomas 
Published: April 2022

Tulobuterol Transdermal Drug Delivery (TTD) may be beneficial in COPD management. We aimed to study the effect of adding TTD to Triple Inhalation therapy (TI). Participants on TTD and TI (TTD-TI cohort) and, TI only (TI cohort) were identified at the out-patient pharmacy counter. There was no loss to follow-up from 35 participants each enrolled in the cohorts. They were assessed with Modified British Medical Research Council questionnaire (modified Medical Research Council), COPD Control Questionnaire (CCQ) and COPD Assessment Test (CAT). The latter two were repeated at the end of six months. The change in score were compared with Mann-Whitney-U test. Mean age of participants in years was 63.4 and 65.7; 31% and 20% were females and rest were males in TTD-TI and TI cohorts respectively. All of them had modified Medical Research Council grade 2 or above. CCQ and CAT scores were comparable at baseline. Change in both CCQ and CAT scores were statistically significant between the cohorts (p&#60;0.001). Median (minimum, maximum) change in CCQ score were -0.6(-2.8, 0) in TTD-TI cohort and 0.3(-2 to 1.2) in TI cohort. Median (minimum, maximum) change in CAT score were -4(-16, -2) in TTD-TI cohort and 2(-7 to 7) in TI cohort. All of the participants in TTD-TI cohort and, 5(14.3%) and 7(20%) participants improved in TI cohort by CCQ and CAT score respectively. There would be a subjective improvement with addition of tulobuterol transdermal patch on to triple inhalation therapy for older persons with COPD.
The coexistence of bronchial asthma in patients with bronchiectasis: A cross sectional study
Authors: Sudhakar Nayantara 
Published: April 2022

To determine the co-existence of bronchial asthma in patients of bronchiectasis, and to compare the clinico-radiological profile between patients having only bronchiectasis and both bronchiectasis and bronchial asthma.: 67 patients who presented as Bronchiectasis (Clinical and radiological) to Respiratory Medicine Department at VIMS & RC, Bangalore from January 2020 to June 2021, were subjected to baseline investigations and spirometry/PEFR after informed consent. Statistical analysis was performed using SPSS 22 version software.The clinical and radiological profile were compared between the group having only bronchiectasis and those with bronchiectasis and asthma.Out of the 67 study patients, 55(82.08%) had only bronchiectasis and 12(17.91%) had bronchiectasis with bronchial asthma. In the bronchiectasis only group, majority of the patients were male 40(72.72%) and in the in bronchiectasis with bronchial asthma group majority of the patients were female 7(58.33%) which was statistically significant (P value &#60;0.05). Patients with bronchiectasis and coexisting asthma had statistically significant increased symptoms of breathlessness, wheeze, running nose, sneezing, itching (P value &#60;0.05). Similarly exposure to dust, fumes, pets was found to be more common in bronchiectasis with bronchial asthma group (P value &#62;0.05). The mean age for onset of symptoms was found to be lower in the bronchiectasis with bronchial asthma group. Patients in the bronchiectasis with bronchial asthma group had a lower mean FEV1 value. Hyperinflation on chest radiograph was found to be 10.90% in bronchiectasis group, and 8.33 % in bronchiectasis with bronchial asthma group. Bilateral bronchiectasis on CT thorax was common in both groups.17.91% of bronchiectasis patients had coexisting bronchial asthma. Hence, a proper diagnosis can reduce the burden of patients suffering from more frequent exacerbations, with better optimized treatment options.
MA‘NĀ TAQLĪD "AL-SAKBAH" (TER-ATER) FĪ SYAHR RAMADLĀN BĪ SAMPANG MADURA
Authors: Wahyudi Arif , Muttaqin.ilunks@gmail.com Khairul 
Published: April 2022

ملخص البحث
التقليد في الدراسة الإسلامية يسمى بالعرف، وهو أمر مألوف لبعض الناس لأنه أصبح عادة تتكامل مع حياتهم أقوالا كانت وأفعالا. فالتقليد الذي لا يزال تتطور في مجتمع سامبانج هي عادة “السكبة” (تير أتير-ter-ater)، وهي عادة بسكب (إعطاء) صحن من الطعم والتبادل للجيران والأقارب والأشخاص الأكابر في الأسرة بصورة خاصة. فكل الشهر القمرية، مارس الناس هذه العادة المحلية بأطعمة مختلفة. وفي هذا البحث، ركز الباحثون على بحث الثقافة في منطقة سامبانج (Sampang) لأن هذه المنطقة معروفة بتعصبها في الامور الدينية والتقاليد. كما تم تحديد إجراء هذا البحث في شهر رمضان، لأن في ذلك الشهر لا تزال هذه العادة كثيفًا للغاية من قبل غالبية المجتمع. عند مقدمة البحث، فقد تم تنفيذ هذا التقليد لأجيالهم. هم لا يعرفون متى وجود هذه العادة بالضبط وهذا الذي يدعم الباحثون في بعث هذه العادة. ومن خلال الدراسة الميدانية، تحلل هذه الورقة تطبيق ومعنى عادة السكبة (ter-ater) في منطقة سامبانج. نتجت هذه الورقة، أن اختيار الطعام في عادة السكبة (ter-ater) وفقًا للمجتمع على القدرة الاقتصادية وليس له معنى محدود. أما تحديد الشهر والتاريخ عند بعض الناس للحث على الحصول وبركات رمضان وليلة القدر لأن النبي يتحرى على ليلة القدر في ليالي الوتر من العشر الأواخر من رمضان.

ABSTRAK
Dalam kajian keislaman, tradisi disebut `urf yaitu sesuatu yang tidak asing bagi masyarakat tertentu karena telah menjadi kebiasaan yang menyatu dengan kehidupan mereka baik berupa perkataan maupun perbuatan. Tradisi yang hingga kini masih berkembang di masyarakat Sampang adalah tradisi ter-ater, yakni tradisi saling hantar makanan ke tetangga, saudara, dan orang-orang yang dituakan dalam keluarga. Bahkan masyarakat melakukan tradisi ini dengan makanan yang berbeda-beda setiap bulan Kamariah. Artikel ini fokus pada budaya ter-ater di Kabupaten Sampang Madura pada bulan Ramadan, karena masyarakatnya fanatik terhadap agama dan tradisi dan pada bulan tersebut tradisi ini masih sering dilakukan. Tradisi ini telah dilakukan turun-temurun yang tidak diketahui awal mula serta alasan di baliknya. Dengan kajian lapangan, artikel ini fokus pada tiga hal yakni: pertama, praktik dan makna ater-ater di bulan Ramadan. Kedua, praktik masyarakat Sampang dalam memburu lailatulkadar. Artikel ini berhasil mengungkap bahwa pemilihan makanan pada tradisi ter-ater menurut masyarakat disesuaikan dengan kemampuan ekonomi masing-masing dan tidak memilki makna tertentu. Terkait penetuan bulan dan tanggal menurut sebagian masyarakat karena termotivasi keinginan untuk mendapatkan berkah Ramadan serta lailatul kadar karena Nabi menyerukan agar mencari lailatulkadar pada malam-malam ganjil di sepuluh akhir Ramadan.