bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical features and prognostic factors of Magnusiomyces (Saprochaete) infections in haematology. A multicentre study of SEIFEM/Fungiscope
Authors: Del Principe Maria Ilaria , Seidel Danila , Criscuolo Marianna , Dargenio Michelina , Rácil Zdenek , Piedimonte Monica , Marchesi Francesco , Nadali Gianpaolo , Koehler Philipp , Fracchiolla Nicola , Cattaneo Chiara , Klimko Nikolai , Spolzino Angelica , Yilmaz Karapinar Deniz , Demiraslan Hayati , Duarte Rafael F. , Demeter Judit , Stanzani Marta , Melillo Lorella Maria Antonia , Basilico Claudia Maria , Cesaro Simone , Paterno Giovangiacinto , Califano Catello , Delia Mario , Buzzatti Elisa , Busca Alessandro , Alakel Nael , Arsenijevi'c Valentina Arsi'c , Camus Vincent , Falces‐Romero Iker , Itzhak Levy , Kouba Michal , Martino Rodrigo , Sedlacek Petr , Weinbergerová Barbora , Cornely Oliver A. , Pagano Livio ,   FUNGISCOPE (Global Emerging Fungal Infection Registry) and the SEIFEM (Sorveglianza Epidemiologica Infezioni nelle Emopatie)
Published: September 2022

AbstractBackgroundOur multicentre study aims to identify baseline factors and provide guidance for therapeutic decisions regarding Magnusiomyces‐associated infections, an emerging threat in patients with haematological malignancies.MethodsHM patients with proven (Magnusiomyces capitatus) M. capitatus or (Magnusiomyces clavatus) M. clavatus (formerly Saprochaete capitata and Saprochaete clavata) infection diagnosed between January 2010 and December 2020 were recorded from the SEIFEM (Sorveglianza Epidemiologica Infezioni nelle Emopatie) group and FungiScope (Global Emerging Fungal Infection Registry). Cases of Magnusiomyces fungemia were compared with candidemia.ResultsAmong 90 Magnusiomyces cases (60 [66%] M. capitatus and 30 (34%) M. clavatus), median age was 50 years (range 2–78), 46 patients (51%) were female and 67 (74%) had acute leukaemia. Thirty‐six (40%) of Magnusiomyces‐associated infections occurred during antifungal prophylaxis, mainly with posaconazole (n = 13, 36%) and echinocandins (n = 12, 34%). Instead, the candidemia rarely occurred during prophylaxis (p < .0001). First‐line antifungal therapy with azoles, alone or in combination, was associated with improved response compared to other antifungals (p = .001). Overall day‐30 mortality rate was 43%. Factors associated with higher mortality rates were septic shock (HR 2.696, 95% CI 1.396–5.204, p = .003), corticosteroid treatment longer than 14 days (HR 2.245, 95% CI 1.151–4.376, p = .018) and lack of neutrophil recovery (HR 3.997, 95% CI 2.102–7.601, p < .001). The latter was independently associated with poor outcome (HR 2.495, 95% CI 1.192–5.222, p = .015).ConclusionsMagnusiomyces‐associated infections are often breakthrough infections. Effective treatment regimens of these infections remain to be determined, but neutrophil recovery appears to play an important role in the favourable outcome.
A Novel Suture‐Preset Spring Plate System (SSPS) for Comminuted Coronoid Process Fracture in the Elbow
Authors: Yan Ruijian , Wu Yifan , Xiang Zhihui , Li Sihao , Qi Yiying , Li Hang , Zhuang Chengyu , Feng Gang 
Published: September 2022

ObjectiveThis study is aimed to investigate the clinical outcomes of a novel SSPS for fixation of the comminuted coronoid fracture.MethodsA retrospective study was carried out in the patients with comminuted fractures of the coronoid treated by SPSS fixation between January 2014 and December 2018. A total of 17 patients (17 sides) was included in our study, including 11 male and six female, with a mean age range from 18 to 60. All cases started to functional rehabilitation immediately after the operation. Clinical outcomes were evaluated both radiographically and functionally at the follow‐up visit, including the elbow instability, range of motion and Mayo elbow performance score (MEPS).ResultsAccording to the O'Driscoll classification system, there was two side of type 1.2, two of type 2.1, four of type 2.2, three of type 2.3, two of 3.1 and four of type 3.2. The surgery was carried out by Kocher and anteromedial approach in 12 patients, posterior and anteromedial approach in four, anterior approach in one. The average operation time and intraoperative blood loss was 129.41±43.87 min and 115.29±104.65 ml. The median follow‐up time was 9 months (range, 6 to 15 months). The mean flexion, extension, pronation and supination motion was 138.76±8.67 degrees, 20.00±13.58, 82.94±5.32and 74.12±14.39 respectively at final follow up. The mean MEPS score was 89.76±8.46, including 11 excellent, 3 good and 3 fair result. The mean VAS score was 1.94±0.97. The mean union time of coronoid fractures was 2.77±0.31 months according to the established standard of healing. There were no significant differences in clinical outcomes among groups according to the O'Driscoll classification (P > .05) and ligament repair strategy (P > .05). No patient underwent instability or dislocation of the elbow during follow up. There were two cases with mild ulnar nerve symptoms which recovered totally at follow up. Meanwhile, there were three cases with heterotopic ossification of the elbow.ConclusionOur findings demonstrated that the SSPS can provide a reliable fixation for the comminuted coronoid fracture with satisfactory clinical outcomes.
Association of maternal low‐carbohydrate‐diet score during pregnancy with allergic diseases at 2 years of age
Authors: Chen Xi , Lin Lixia , Huang Li , Wu Meng , Tan Tianqi , Li Qian , Zhong Chunrong , Wang Huanzhuo , Wang Weiming , Sun Guoqiang , Yi Nianhua , Yang Xuefeng , Hao Liping , Yang Hongying , Yang Nianhong 
Published: September 2022

AbstractBackgroundWe prospectively evaluated the association between low‐carbohydrate‐diet (LCD) score during pregnancy and the risk of allergic diseases in infants up to 2 years.MethodsParticipants were from a prospective mother‐offspring cohort study in Wuhan, China. LCD score was calculated according to the percentage of dietary energy intake from carbohydrate, protein, and fat assessed in late pregnancy using validated food frequency questionnaires. Allergic diseases, including immunoglobulin E (IgE)‐mediated allergic diseases, allergic contact dermatitis, and food allergy, were recorded at 3, 6, 12, and 24 months postpartum follow‐up. Poisson regression models were used to calculate relative risks (RRs) and 95% confidence intervals (CIs).ResultsAmong 1636 mother–infant pairs included in the present analysis, 230 infants (14.1%) with IgE‐mediated allergic diseases, 77 (4.7%) with allergic contact dermatitis, and 488 (29.8%) with food allergy were, respectively, reported. Independent of total energy intake and other potential confounders, both the lowest quintile (RR, 1.77; 95% CI, 1.13–2.77) and the highest quintile (RR, 1.72; 95% CI, 1.22–2.63), were associated with the risk of IgE‐mediated allergic diseases compared with the middle quintile. Among high‐carbohydrate‐diet pregnant women, substituting 5% of energy from either protein or fat for carbohydrate was associated with a lower risk of IgE‐mediated allergic diseases. While among low‐carbohydrate‐diet pregnant women, substituting 5% of energy from carbohydrate, especially high‐quality carbohydrate, for fat was associated with a lower risk of IgE‐mediated allergic diseases.ConclusionMaternal low carbohydrate‐high protein and fat, and high carbohydrate‐low protein and fat diet were both associated with an increased risk of allergic diseases in the infants up to 2 years. This study may provide an intervention strategy for allergy prevention in early childhood.
Risk of injuries requiring hospitalization in attention deficit hyperactivity disorder and the preventive effects of medication
Authors: Pai Ming‐Shang , Yang Szu‐Nian , Chu Chi‐Ming , Lan Tzuo‐Yun 
Published: September 2022

AimsPatients with attention deficit hyperactivity disorder (ADHD) are prone to injury and frequently require treatment with hospital admission. This study aimed to evaluate the risk of injuries requiring hospitalization among children and adolescents with and without ADHD and assess the effects of medication on the risk reduction in patients with ADHD.MethodsThis is a retrospective population‐based cohort study by using data from the Taiwan National Health Insurance Research Database. We compared 4658 6–18 year‐old ADHD patients with 18 632 sex‐, age‐, and index day‐matched non‐ADHD controls between 2005 and 2012. Both groups were followed until the end of 2013 to compare the risk of injuries requiring hospitalization. Cox regression analysis was performed to determine the hazard ratio (HR) with 95% confidence intervals (CI) after adjusting for confounders.ResultsChildren and adolescents with ADHD had a significantly higher risk of injuries requiring hospitalization than the non‐ADHD controls (HR = 1.39, 95% CI = 1.12–1.72), and a higher risk was especially observed in the male and adolescent subgroups. In ADHD patients, long‐term users of ADHD medication were associated with a lower risk of injuries requiring hospitalization than nonusers (HR = 0.51, 95% CI = 0.30–0.85).ConclusionHealthcare providers should be aware of the potential risk of injury in patients with ADHD and highlight the importance of the duration and compliance with medication treatment.
Ultrathin bronchoscopic cryobiopsy of peripheral pulmonary lesions
Authors: Oki Masahide , Saka Hideo , Kogure Yoshihito , Niwa Hideyuki , Yamada Arisa , Torii Atsushi , Kitagawa Chiyoe 
Published: September 2022

AbstractBackground and ObjectiveUltrathin bronchoscopy aids in the diagnosis of peripheral pulmonary lesions. However, both the working channel and the specimens are small. A 1.1‐mm ultrathin cryoprobe that can enter the working channel of the ultrathin bronchoscope is now available, which may overcome the limitations of small specimen size. The aim of this study was to evaluate the feasibility, efficacy and safety of ultrathin bronchoscopic cryobiopsy using an ultrathin cryoprobe for diagnosing peripheral pulmonary lesions.MethodsPatients with peripheral pulmonary lesions ≤30 mm in diameter were prospectively enrolled in the study. All patients underwent forceps biopsy followed by cryobiopsy using a 3.0‐mm ultrathin bronchoscope under radial probe endobronchial ultrasound guidance, virtual bronchoscopic navigation and fluoroscopic guidance. The primary endpoint was the feasibility of cryobiopsy.ResultsIn total, 50 patients with peripheral pulmonary lesions were enrolled in the study; the median longest diameter on computed tomography was 17.9 mm. Cryobiopsy was performed successfully in 49 patients (98%). Forceps biopsy, cryobiopsy and the combination of these two methods provided a specific diagnosis in 54% (27/50), 62% (31/50) and 74% (37/50) of patients, respectively. The median size of specimens obtained via cryobiopsy was significantly larger than the median size obtained via forceps biopsy (7.0 vs. 1.3 mm2, respectively, p < 0.001). Mild bleeding during cryobiopsy occurred in 47 patients (94%). No moderate/severe bleeding or pneumothorax occurred.ConclusionUltrathin bronchoscopic cryobiopsy is feasible, effective and sufficiently safe for the diagnosis of peripheral pulmonary lesions.
Experiences of pregnant people affected by natural disasters: a qualitative systematic review protocol
Authors: Suzuki Satoko , Sato Naho , Miyazaki Misako 
Published: September 2022

ABSTRACT

Objective:
This qualitative systematic review will identify, appraise, and synthesize existing qualitative evidence regarding the experiences of pregnant people during a natural disaster to gain a deeper understanding of the complex factors influencing their experiences.

Introduction:
During natural disasters, pregnant people would benefit from health workers, including nurses, midwives, and other professionals, considering their needs and providing support to address complex factors, including family relationships, social support, and stress; however, little is known about the experiences of pregnant people during a natural disaster. This study is the first qualitative systematic review of the experiences of pregnant people during a disaster.

Inclusion criteria:
This review will include studies that focus on pregnant people's experiences of living in a disaster area during a natural disaster. It will include both published and unpublished qualitative studies, with data collected through interviews and observations, in either English or Japanese.

Methods:
The databases and other sources to be searched include MEDLINE, CINAHL, and PsycINFO (in English); and CiNii and Ichushi-Web (in Japanese). Further, we will cross-check the reference lists of included studies with search outcomes to identify any additional studies suitable for analysis. The search for gray literature will be conducted using Google Scholar and ProQuest. We will use the recommended JBI approach for study selection, critical appraisal, data extraction, and data synthesis.

Systematic review registration number:
PROSPERO CRD42021265326
Funding systems for care needs of older adults in residential aged care facilities in the Asia-Pacific region: a scoping review protocol
Authors: Grady Ashley , Lim David , Liu Karen P.Y. 
Published: September 2022

ABSTRACT

Objective:
The objective of this review is to explore the care needs as assessed by the public residential aged care funding systems of Asia-Pacific countries that use both taxation and means-tested user charge.

Introduction:
The Asia-Pacific region is at the forefront of population aging. There is increasing reliance on residential aged care facilities to provide formal care, but limited understanding of how care needs are assessed. Most countries have adopted taxation as the primary means to levy capital for funding essential health services; funding may be means-tested for equity.

Inclusion criteria:
The population of interest is older adults eligible for care in residential aged care facilities who receive assistance to fund their care. Sources that address the care needs of residents and the assessments relating to care needs, as well as funding systems (taxation, means-testing), will be considered for inclusion. This review will consider any quantitative study, qualitative study, mixed method study, or report from any country in the Asia-Pacific region.

Methods:
Databases to be searched include Embase, CINAHL, PubMed, Scopus, and the JBI Database for Evidence-based Practice. Additional records will be identified through the gray literature database Trove, reference lists of included studies, and relevant health organization websites. Sources published in English since 2008 will be eligible for inclusion. Two reviewers will independently screen titles, abstracts, and full-texts for inclusion. Data will be extracted and findings summarized in tabular format and narrative synthesis. Any disagreements between the reviewers will be resolved through discussion or with the third reviewer.

Scoping review registration:
Open Science Framework; https://doi.org/10.17605/OSF.IO/H9G7Q
Experiences of parents and prospective parents when receiving a diagnosis of Down syndrome for their child in the perinatal period: a qualitative systematic review protocol
Authors: Robinette Bethany , Palokas Michelle , Christian Robin , Hinton Elizabeth 
Published: September 2022

Objective:
The objective of this review is to synthesize qualitative evidence regarding the experiences of parents and prospective parents when receiving a diagnosis of Down syndrome for their child in the perinatal period.

Introduction:
Increased awareness of parental experiences when receiving a Down syndrome diagnosis for their child may help health care professionals provide the parental support needed to promote the best possible outcomes for these children.

Inclusion criteria:
The participants for this review are the parents and prospective parents of a child with Down syndrome. The phenomenon of interest is parents’ and prospective parents’ experiences when receiving the diagnosis of Down syndrome for their child in the perinatal period. Experiences of prospective parents, parents whose children are living or deceased, and those who terminated a pregnancy because of the diagnosis will be included.

Methods:
This review will follow JBI methodology for qualitative reviews. The databases to be searched include Academic Search Premier, AccessPediatrics, Health Source: Nursing/Academic Edition, MEDLINE, CINAHL, Scopus, PsycINFO, and Web of Science. Sources of unpublished studies and gray literature will include ProQuest Dissertations and Theses Sciences and Engineering Collection, MedNar, National Association for Down Syndrome, Down Syndrome International, and WorldWideScience. Studies will be critically appraised by 2 independent reviewers. All studies, regardless of methodological quality, will be included. Data will be extracted by 2 independent reviewers. Findings will be pooled using the meta-aggregation approach. Where textual pooling is not possible, the findings will be presented narratively. The final synthesized findings will be graded according to the ConQual approach.

Systematic review registration number:
PROSPERO CRD42021250813
Interventions to improve patient experience in mammography: a scoping review protocol
Authors: Ding Sandrine , Fontaine Tamara , Serex Magali , Reis Cláudia Sá dos 
Published: September 2022

ABSTRACT

Objective:
The objective of this review is to map the global evidence on interventions aiming to enhance the patient experience during mammography examination.

Introduction:
Mammography is the examination of choice to detect breast cancer, which is the most common malignant condition among women globally. However, this examination can cause psychological distress, discomfort, and pain for patients. To limit these negative experiences, and to promote patient engagement in diagnostic and screening examinations, some interventions have been tested in clinical practice. Each intervention has key differing features that need to be explored in a scoping review. This mapping will help inform mammography professionals and researchers.

Inclusion criteria:
This review will consider studies that focus on women, men, transgender, nonbinary, or intersexual persons undergoing diagnostic or screening mammography. It will consider studies evaluating interventions and reporting data on the patient experience. These interventions may, for instance, be related to the information provided, breast compression, relaxation, medication, or physical environment. The review will also describe the outcomes related to patient experience (eg, anxiety, pain, discomfort).

Methods:
The search strategy will aim to find published and unpublished studies and will be conducted in MEDLINE, Embase, CINAHL, PsycINFO, Cochrane Central Register of Controlled Trials, Web of Science, and ProQuest Dissertation and Theses. Furthermore, three registries will be searched for ongoing studies. This review will be conducted following JBI methodology, utilizing the three-step search strategy with two independent reviewers performing study selection and data extraction. The results, frequencies, and conceptual categories will be presented in a tabular and narrative summary.

Scoping review registration:
Open Science Framework (https://osf.io/fn865/)
Safety and effectiveness of regional anesthesia compared with anesthetic techniques not using regional anesthesia on outcomes after free tissue flap surgery: a systematic review protocol
Authors: Smith Avery , Weigand Jean , Greenwood Jennifer , Tierney Kristine 
Published: September 2022

ABSTRACT

Objective:
This systematic review will aim to evaluate the evidence on the effectiveness of regional anesthesia, when compared with general anesthesia alone, on the outcomes of free flap surgeries.

Introduction:
Free flap procedures involve complete separation of a flap of tissue from its native vascular bed, followed by reimplantation to a recipient site on the body. Optimal perfusion and successful neovascularization are crucial to survival of the grafted flap. Currently, no best-practice recommendations exist regarding the use of regional anesthesia in free flap surgeries. Regional anesthesia techniques have the potential to alter blood flow and neuroendocrine responses to surgical stress, which may impact perfusion and survival of free flap grafts. This potential for augmentation or hindrance of flap perfusion may have a significant impact on patient outcomes, thus meriting systematic review.

Inclusion criteria:
The review will include both experimental and observational (analytical only) study designs that examine the vascular outcomes of regional anesthesia compared with general anesthesia alone in free flap surgery.

Methods:
The databases to be searched include PubMed, CINAHL, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science Core Collection, Embase, and gray literature sources. Identified studies will be independently assessed by two reviewers utilizing JBI critical appraisal tools. Data will be extracted using a standardized data matrix. Certainty of findings will be conducted using the Grading of Recommendations Assessment, Development and Evaluation approach. Narrative synthesis will be compiled and meta-analysis completed, where possible.

Systematic review registration number:
PROSPERO CRD42021283584
Comparison of human amniotic membrane decellularisation approaches for hESC-derived RPE cells culture
Authors: Daniele Elena , Ferrari Barbara , Rassu Nicolò , Ben-Nun Joshua , Bosio Lorenzo , Barbaro Vanessa , Ferrari Stefano , Ponzin Diego 
Published: September 2022

ObjectiveRecent clinical studies have shown that the transplantation of functional retinal pigment epithelium (RPE) cells can prevent the onset of RPE degeneration in age-related macular degeneration. This study aimed to investigate the potential of human amniotic membrane (hAM) as a viable scaffold for the growth and proliferation of pluripotent-derived RPE cells.Methods and analysisThree enzymatic hAM de-epithelialisation methods (thermolysin, trypsin-EDTA and dispase II) were assessed by histological analysis and optical coherence tomography (OCT). We generated RPE cells from a human embryonic stem cell (hESC) line subjected to spontaneous differentiation in feeder-free conditions. The hESC-derived RPE cells were seeded over denuded hAM at a density of 2.0×105cells/cm2and maintained in culture for up to 4 weeks. Immnofluorescence was carried out to evaluate the development of a confluent monolayer of RPE cells on the top of the hAM. Conditioned medium was collected to measure pigment epithelium-derived factor (PEDF) concentration by ELISA.ResultsLaminin α5 and collagen IV staining confirmed the efficiency of the de-epithelialisation process. In particular, thermolysin showed good retention of tissue integrity on OCT images and greater preservation of the hAM basement membrane. The hESC-derived RPE cells formed patches of pigmented cells interspersed along the denuded hAM, but failed to form a regular sheet of RPE cells. These cells expressed typical RPE markers, such as PMEL17 and RPE65, but they secreted low levels of PEDF.ConclusionThe biological variability of the hAM could influence the adhesion and the expansion of hESC-derived RPE cells. Further studies are required to verify whether a non-confluent monolayer might represent a limit to transplantation.