bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial frequency of environments and myopia: A systematic review on associated evidence and underlying mechanisms
Authors: Li Dan‐Lin , Lanca Carla , Zhang Xiu‐Juan , Grzybowski Andrzej , He Xian‐Gui , Pan Chen‐Wei 
Published: January 2025

AbstractPurposePrevious animal studies have found a relationship between spatial frequency and myopia. New research in humans suggest that reduced high spatial content of the visual environment may be a contributing factor for myopia development. This study aims to review the literature and elucidate the potential biological mechanisms linking spatial frequency and myopia.MethodsA systematic search was conducted across PubMed and Web of Science databases. The studies published from their inception to August 2024 that have explored the connection between spatial frequency and myopia. Only full‐text articles in English were included. PRISMA was used for data validity.ResultsA total of 13 articles were included in this review, comprising seven animal model studies, four population‐based studies, one pictorial analysis and one study on research design. Epidemiological evidence is comparatively limited and has only begun to emerge in recent years. Mid‐ to high spatial frequencies were found to play an important role in the emmetropization process of the eye. Low spatial frequencies can increase the risk of myopia incidence. Furthermore, the potential mechanisms of how spatial frequency affects myopia are summarized as visual information processing characteristics, eye accommodation function and eye movements, contrast sensitivity and relevant molecules involved in the pathway.ConclusionThe evidence suggests that indoor spatial frequency may be related to the development of myopia. Further studies are warranted to understand if the incorporation of changes in indoor environments is helpful in the prevention and control of myopia.
Limited benefits of organic management and fungicide reduction to ground beetles in vineyards
Authors: Gieser Julia T. , Kolb Sebastian , Reiff Jo Marie , Riess Kai , Hunke Maura , Entling Martin H. , Schirmel Jens 
Published: January 2025

AbstractThe use of fungicides in agriculture can reduce animal biodiversity. Such non‐target effects could be mitigated through fungus‐resistant cultivars that reduce the need for fungicide applications. Hence, we conducted a study in 32 commercial vineyards in southwest Germany. We investigated the effect of fungicide spraying intensities (susceptible vs resistant cultivars) and management (conventional vs organic) on ground beetles as a widely used indicator group in agroecological studies. In addition, we examined the effects of local habitat conditions (e.g., microclimate, vegetation) and landscape characteristics. Fungicide applications were reduced by half in conventional, and almost by two‐thirds in organic vineyards with fungus‐resistant cultivars, compared to susceptible grape varieties in the same management regime. While there was no evidence that fungus‐resistant cultivars positively affect the diversity of ground beetles, organic management doubled the number of individuals of conservation‐relevant species per vineyard. Additionally, the proportion of semi‐natural habitats in the surrounding landscape, and the vegetation height significantly affected the species composition across vineyards. We conclude that local habitat conditions and landscape characteristics influence ground beetles more than the fungicide spraying intensity. Additional measures such as organic management, moderate ground vegetation management, and landscape diversification are needed for the conservation of ground beetles in viticulture.
A novel BLK heterozygous mutation (p.Met121lle) in maturity‐onset diabetes mellitus: A case report and literature review
Authors: Xu Fenjuan , Chen Xiaoting , Hu Tingting , Sun Ruqiong , Zhu Fangying , Wu Xiaohong 
Published: January 2025

AbstractMaturity onset diabetes of the young (MODY) is a highly heterogeneous monogenic disease that occurs due to β‐cell dysfunction. It is divided into different types depending on the gene mutated, and a total of 16 genes have been found to be associated with MODY. However, due to the current lack of understanding of monogenic diabetes, 90% of MODY is currently misdiagnosed and ignored in clinical practice. In this paper, we report the clinical data of a patient diagnosed with diabetes. Genetic testing revealed a novel BLK heterozygous mutation (c.363G>A) in the patient and in his father and son. He had no islet‐specific autoantibodies and showed a reduced meal‐induced response of insulin. Precise diagnosis of MODY individuals is important to the treatment.
HLA‐E: Immune Receptor Functional Mechanisms Revealed by Structural Studies
Authors: Gillespie Geraldine M. , Quastel Max N. , McMichael Andrew J. 
Published: January 2025

ABSTRACTHLA‐E is a nonclassical, nonpolymorphic, class Ib HLA molecule. Its primary function is to present a conserved nonamer peptide, termed VL9, derived from the signal sequence of classical MHC molecules to the NKG2x‐CD94 receptors on NK cells and a subset of T lymphocytes. These receptors regulate the function of NK cells, and the importance of this role, which is conserved across mammalian species, probably accounts for the lack of genetic polymorphism. A second minor function is to present other, weaker binding, pathogen‐derived peptides to T lymphocytes. Most of these peptides bind suboptimally to HLA‐E, but this binding appears to be enabled by the relative stability of peptide‐free, but receptive, HLA‐E‐β2m complexes. This, in turn, may favor nonclassical antigen processing that may be associated with bacteria infected cells. This review explores how the structure of HLA‐E, bound to different peptides and then to NKG2‐CD94 or T‐cell receptors, relates to HLA‐E cell biology and immunology. A detailed understanding of this molecule could open up opportunities for development of universal T‐cell and NK‐cell‐based immunotherapies.
MAP Kinase Signaling at the Crossroads of Inflammasome Activation
Authors: Vervaeke Alex , Lamkanfi Mohamed 
Published: January 2025

ABSTRACTInflammasomes are crucial mediators of both antimicrobial host defense and inflammatory pathology, requiring stringent regulation at multiple levels. This review explores the pivotal role of mitogen‐activated protein kinase (MAPK) signaling in modulating inflammasome activation through various regulatory mechanisms. We detail recent advances in understanding MAPK‐mediated regulation of NLRP3 inflammasome priming, licensing and activation, with emphasis on MAPK‐induced activator protein‐1 (AP‐1) signaling in NLRP3 priming, ERK1 and JNK in NLRP3 licensing, and TAK1 in connecting death receptor signaling to NLRP3 inflammasome activation. Furthermore, we discuss novel insights into MAPK signaling in human NLRP1 inflammasome activation, focusing on the MAP3K member ZAKα as a key kinase linking ribosomal stress to inflammasome activation. Lastly, we review recent work elucidating how Bacillus anthracis lethal toxin (LeTx) manipulates host MAPK signaling to induce macrophage apoptosis as an immune evasion strategy, and the counteraction of this effect through genotype‐specific Nlrp1b inflammasome activation in certain rodent strains.
Barriers and Enablers in the Implementation of Physical Activity Improvement for Pregnant Women With Gestational Diabetes Mellitus: A Mixed‐Methods Study
Authors: Wang Yan , Zhu Wei , Pu Yan , Wang Yuyang , Luo Biru 
Published: January 2025

ABSTRACTAimTo identify the barriers and enablers in the implementation of evidence‐based physical activity (PA) programmes for the improvement of health outcomes among pregnant women with gestational diabetes mellitus (GDM), and to develop strategies for implementing this evidence in clinical practice.MethodsA convergent mixed‐methods study was conducted, integrating a descriptive qualitative research design with a cross‐sectional survey. In‐depth interview was used to collect the views and cognitions about physical activity from medical staff, leaders and pregnant women. The qualitative data was analysed using directed content analysis, guided by the Ottaw Model of Research Use (OMRU). A self‐designed questionnaire, which was based on the current best evidence for physical activity during pregnancy, was administered to gather data regarding nurse’ knowledge of physical activity (PA safety, managing blood glucose with PA, etc.), their management practice (timing of assessments, provision of information, etc.), as well as the knowledge levels of physical activity among pregnant women with GDM (principles of exercise, PA precautions, etc.).ResultsA total of 12 medical staff members and 14 pregnant women were interviewed. Ten nurses and 102 pregnant women with GDM completed the questionnaire. We generated 12 subthemes organised within three themes of the OMRU from the data, including insufficient professional autonomy, positive attitudes towards evidence implementation, shortage of nursing staff, implementation climate, etc. The average knowledge score of physical activity among nurses and pregnant women was 5 (SD 2.36) points and 5.2 (SD 1.70) points, respectively. Ten strategies for overcoming barriers and amplifying enablers for the implementation of the physical activity improvement programme for pregnant women with GDM, under the guidance of the OMRU were constructed.ConclusionAn accumulation of evidence, adopters and practice environment factors across the OMRU domains explains why physical activity improvement initiatives for pregnant women with GDM are hard to implement.ImpactsThis study helps to recognise barriers and facilitators to physical activity improvement particularly at the evidence, potential adopter and practical environment level.PatientHealthcare workers (doctors, nurses, etc.) and pregnant women with GDM in a university hospital located in Sichuan Province.
Color Change and Cytotoxic Effects of a Bleaching Gel With 22% Carbamide Peroxide Catalyzed by Manganese Oxide
Authors: de Oliveira Ribeiro Rafael Antonio , Peruchi Victória , Sônego Leonardo Novaes Gaeta , Soares Igor Paulino Mendes , Soares Diana Gabriela , Hebling Josimeri , de Souza Costa Carlos Alberto 
Published: January 2025

ABSTRACTObjectivesTo evaluate the color change and trans‐amelodentinal cytotoxicity of a 22% carbamide peroxide (CP) bleaching gel containing different concentration of manganese oxide (MnO2).Material and MethodsEnamel/dentin discs adapted to artificial pulp chambers were distributed according to treatments: CN—No treatment; CP22%–22%CP; CP22 + 2MnO2–22%CP + 2 mg/mLMnO2; CP22% + 6MnO2–22%CP + 6 mg/mLMnO2; CP22% + 10MnO2–22%CP + 10 mg/mLMnO2 applied for 2 h for 15 days. Color change—CC (ΔE00 and ΔWID) (n = 8) was determined at 5, 10, and 15‐day periods (ANOVA/Sidak). Trans‐amelodentinal cytotoxicity (TC) was assessed after applying the extracts to cultured MDPC‐23 cells, which were analyzed concerning their viability (Vi) (n = 8) and oxidative stress (OxS) (n = 8). The amount of hydroxyl radical (OH•) (n = 4) generated by H2O2 degradation (ANOVA/Sidak), and trans‐amelodentinal diffusion of H2O2 (n = 8) (ANOVA/Tukey) were also evaluated.ResultsCP22 + 10MnO2 presented higher CC than CP22 for both evaluated equations in all analysis periods (p ≤ 0.04). Among bleached groups, CP22 + 10MnO2 presented the highest OH• generation (p ≤ 0.02) and the lowest trans‐amelodentinal diffusion of H2O2 (p ≤ 0.0004). Therefore, MDPC‐23 cells in CP22 + 10MnO2 exhibited the lowest OxS (p < 0.0001) and consequently the highest Vi (p ≤ 0.0146).ConclusionBesides increasing the bleaching efficacy, the strategy of adding 10 mg/mL of MnO2 to a 22%CP bleaching gel also reduces significantly the trans‐amelodentinal diffusion of H2O2, diminishing the cytotoxicity caused by at‐home bleaching therapy.Clinical SignificanceThe addition of MnO2 to a 22% carbamide peroxide bleaching gel improves the color change and reduces the cytotoxicity effects of the product, making at‐home bleaching faster and biologically safer.
Impact of Glucocorticoid‐Associated Stress‐Like Conditions on Aquaporin‐4 in Cultured Astrocytes and Its Modulation by Adenosine A2A Receptors
Authors: Dias Liliana , Nabais Ana Margarida , Borges‐Martins Vladimir P. P. , Canas Paula M. , Cunha Rodrigo A. , Agostinho Paula 
Published: January 2025

ABSTRACTAstrocytes participate in brain clearance of extracellular proteins and metabolites, through the activity of the water channel aquaporin‐4 (AQP4), which can be deregulated in stress‐related disorders, impairing brain waste clearance. The present study investigates the impact of dexamethasone (Dexa), a synthetic glucocorticoid used as a simplified in vitro stress model, on astrocytic AQP4 and its modulation by adenosine A2A receptors (A2AR), which blockade reverses conditions related with maladaptive stress, such as anxiety and depression. The clearance of proteins in primary astrocytic cultures, assessed using 5 kDa FITC‐dextran and 45 kDa TRITC‐dextran uptake, was decreased by a 24 h exposure to 100 nM Dexa. The Dexa exposure decreased α‐syntrophin density, a protein‐targeting AQP4 to astrocytic processes, potentially affecting AQP4 location and, consequently, its activity. Accordingly, Dexa exposure decreased astrocytic water influx (assessed with calcein fluorescence), which paralleled the impairment of dextran clearance. The Dexa‐induced decrease in extracellular protein uptake was prevented by the AQP4 activator TGN‐073 and A2AR antagonism with SCH58261, showing that the impairment of AQP4‐mediated protein clearance was controlled by A2AR in this Dexa‐simplified in vitro stress model. Additionally, the effects of Dexa in AQP4 location and activity were prevented by SCH58261, confirming that A2AR modulate AQP4 function. This conclusion was reinforced by the observed AQP4/A2AR physical interaction in astrocytes. Overall, the data indicate that in vitro conditions related to stress affect the localisation of astrocytic AQP4 and its role in extracellular protein uptake, which was modulated by A2AR. These findings unveil a novel therapeutic mechanism to prevent brain extracellular protein accumulation and associated neurological disorders by tinkering with AQP4 and A2AR.image
Intradermal Incobotulinum Toxin A for Postbreast Cancer Treatment Asymmetry: A Literature Review and Case Report
Authors: Bugallo Alejandra , Parra Luis Alberto , Amado Andreina Martinez , De la Fuente Victoria , Murúa Evalicia , Garcés Eliana , Parra Andrea Marcela 
Published: January 2025

ABSTRACTBackgroundBotulinum toxin (BTX) is globally the most common aesthetic procedure. Its usage has expanded beyond facial treatments to therapeutic areas, including managing scars and postsurgical deformities. Breast cancer survivors often face significant deformities and asymmetry during recovery.ObjectivesThis study systematically reviewed literature from the past 4 years on botulinum toxin applications in breast cancer survivors and presented a case report of a patient treated with Incobotulinum toxin (IncoBonTA; Xeomin, Merz Pharmaceuticals GmbH, Frankfurt, Germany) for left breast deformity postchemotherapy and radiotherapy.MethodsFollowing PRISMA guidelines, a systematic search was conducted on PubMed and Scopus using keywords: “botulinum toxin,” “breast cancer,” and “breast asymmetry,” identifying relevant literature from 2020 to 2024. Five full‐text articles were included. Additionally, a 2024 case report of a patient with significant breast asymmetry postsurgery and radiotherapy was published.ResultsThe literature review indicated botulinum toxin's primary uses in breast cancer include pain management, upper limb impairment, postsurgical scars, and capsular contracture. Although some benefits were reported, further research is needed. In the case report, the patient was treated in one session with IncoBonTA at two different dilutions based on contracture severity without complications.ConclusionThe review showed promising advances in using botulinum toxin for deformities secondary to oncological treatment in breast cancer patients. The therapy was administered to a 53‐year‐old patient, resulting in significant aesthetic improvement, especially at the nipple and areola, suggesting that it was a viable option for these patients.
Reconfiguring innovation systems for sustainable sectoral transformation: The case of the Norwegian aquaculture industry
Authors: Afewerki Samson , Olsen Marit Schei , Osmundsen Tonje , Størkersen Kristine , Misund Andreas , Thorvaldsen Trine 
Published: January 2025

AbstractThis article aims to shed light on the recent sustainable transformation dynamics of the Norwegian aquaculture industry. Drawing on perspectives from the socio‐technical transition studies this article investigates how this process has been shaped by a specific policy instrument known as development licenses (DL) launched in 2015. The article captures the DL as a transformative innovation policy instrument and shows how this has played a key role in steering the directionality of the technological innovations in the sector to instigate the sustainable transformation process of the industry. The article reveals that the DL has prompted the emergence of new challenged‐oriented innovation systems through reorientation and reconfiguration processes. These processes specifically involved both the mobilization of actor‐networks in the industry, including a functional reorientation by the key regulatory organ—the Directorate of Fisheries—and harnessing locally available pre‐existing knowledge and skills—particularly in the Petro‐maritime industry. The licensing scheme means that the industry is currently in the process of transition to becoming a sector based on multiple aquaculture production technologies. However, we suggest that addressing the long‐term sustainable transformation imperatives of the sector will largely depend upon the ability to identify and support further development of promising niche aquaculture technologies.
Geometry physics neural operator solver for solid mechanics
Authors: Kaewnuratchadasorn Chawit , Wang Jiaji , Kim Chul‐Woo , Deng Xiaowei 
Published: January 2025

AbstractThis study developed Geometry Physics neural Operator (GPO), a novel solver framework to approximate the partial differential equation (PDE) solutions for solid mechanics problems with irregular geometry and achieved a significant speedup in simulation time compared to numerical solvers. GPO leverages a weak form of PDEs based on the principle of least work, incorporates geometry information, and imposes exact Dirichlet boundary conditions within the network architecture to attain accurate and efficient modeling. This study focuses on applying GPO to model the behaviors of complicated bodies without any guided solutions or labeled training data. GPO adopts a modified Fourier neural operator as the backbone to achieve significantly improved convergence speed and to learn the complicated solution field of solid mechanics problems. Numerical experiments involved a two‐dimensional plane with a hole and a three‐dimensional building structure with Dirichlet boundary constraints. The results indicate that the geometry layer and exact boundary constraints in GPO significantly contribute to the convergence accuracy and speed, outperforming the previous benchmark in simulations of irregular geometry. The comparison results also showed that GPO can converge to solution fields faster than a commercial numerical solver in the structural examples. Furthermore, GPO demonstrates stronger performance than the solvers when the mesh size is smaller, and it achieves over 3 and 2 speedup for a large degree of freedom in the two‐dimensional and three‐dimensional examples, respectively. The limitations of nonlinearity and complicated structures are further discussed for prospective developments. The remarkable results suggest the potential modeling applications of large‐scale infrastructures.
Multi‐stage detection of warped ceiling panel using ensemble vision models for automated localization and quantification
Authors: Guo Qinghua , Gao Weihang , Kong Qingzhao , Lu Xilin 
Published: January 2025

AbstractSuspended ceiling systems constitute a pivotal non‐structural component in buildings, and the warping of panels not only compromises the seismic performance but also affects the functional integrity. This paper proposes a novel multi‐stage warped panel detection (MWPD) method to automatically locate warped panels from two‐dimensional images and quantify their deformation. First, the Deep Hough Transform (DHT) is employed to localize the runner line, after that, each detected line is expanded to a rectangular strip. Then ResNet18 classifies the strips as warped or intact. Those classified as warped will undergo Gabor and horizontal Sobel filters successively to highlight the curved edge. Subsequently, the Generalized Hough Transform (GHT) is used to locate pixel points on the curve, and fitting these points yields the pixel‐level radius of curvature. Leveraging known orthogonal relationships and geometric dimensions of runners, pixel quantification is converted into physical maximum deflection. The experiments include two aspects: the first is conducted on a validation dataset to verify the localization stability, and the second is carried out on‐site for quantification validation. Results demonstrate that the proposed MWPD method effectively localizes the warped panel, achieving an accuracy of 92.2% on the validation dataset. Additionally, the quantitative test has achieved an accuracy of approximately 85%.
Gender Comparison of Veterans Crisis Line Risk Ratings and Consequent Suicidal Self‐Directed Violence Outcomes During the COVID Era
Authors: Chhatre Sumedha , Hoffmire Claire A. , Podlogar Matthew C. , Agha Aneeza Z. , Dichter Melissa 
Published: January 2025

ABSTRACTIntroductionImproving gender‐sensitive suicide prevention programming for women veterans is crucial. Veterans Crisis Line (VCL) is a preventive strategy used by the US Department of Veterans Affairs. Public health measures implemented during COVID‐19 pandemic may have affected the nature of VCL calls.ObjectivesTo assess the gender differences in the VCL contacts made in year 2020 and subsequent suicidal self‐directed violence (SSDV) outcomes in the 12 months follow‐up.MethodsCohort study.OutcomesComposite measure of SSDV (dichotomized as nonfatal suicide event and/or suicide) in the 12 months following VCL call.ResultsCompared to veterans with low‐risk assessment, those with high/moderate risk had significantly higher odds of SSDV in the follow‐up year (OR = 4.12, 95% CI: 3.82, 4.45). We assessed the association of gender, combination of VCL risk, and suicide attempt (SA) history, on SSDV. The VCL risk and SA history combinations were independently associated with SSDV. However, there was no differential association on SSDV for different gender/VCL risk and SA history combinations (p = 0.6247).Conclusions and RelevanceOur 2020 VCL data outcomes are largely consistent with those from our prior work examining 2018 VCL contacts. Overall, VCL risk assessment was relatively stable across the gender binary during COVID pandemic.