bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective identification of new psychoactive substances in patient samples submitted for clinical drug analysis
Authors: Axelsson Magnus A. B. , Lövgren Hanna , Kronstrand Robert , Green Henrik , Bergström Moa Andresen 
Published: August 2022

AbstractNew psychoactive substances (NPS) are life threatening through unpredictable toxicity and limited analytical options for clinicians. We present the retrospective identification of NPS in raw data from a liquid chromatography‐high resolution mass spectrometry (LC‐HRMS)‐based multidrug panel analysis on 14 367 clinical oral fluid samples requested during 2019 mainly by psychiatric and addiction care clinics. Retrospectively analysed NPS included 48 notified originally in 2019 by the European Union Early Warning System (EU EWS) and 28 frequently reported in Sweden. Of 88 included NPS, 34 (mitragynine, flualprazolam, 3F/4F‐α‐P(i)HP, etizolam, 4F‐MDMB‐BINACA, cyproheptadine, 5F‐MDMB‐PICA, isotonitazene, isohexedrone, MDPEP, N‐ethylpentedrone, tianeptine, flubromazolam, 4′‐methylhexedrone, α‐P(i)HP, eutylone, mephedrone, N‐ethylhexedrone, 5F‐MDMB‐PINACA, ADB‐BUTINACA, 3‐methoxy PCP, 4F‐furanylfentanyl, 4F‐isobuturylfentanyl, acrylfentanyl, furanylfentanyl, clonazolam, norfludiazepam, 3F‐phenmetrazine, 3‐MMC, 4‐methylpentedrone, BMDP, ethylphenidate, methylone and α‐PVP) were identified as 219 findings in 84 patients. Eight NPS notified in 2019 were identified, five before EWS release. NPS occurred in 1.20% of all samples and 1.53% of samples containing traditional drugs, and in 1.87% of all patients and 2.88% of patients using traditional drugs. NPS use was more common in men and polydrug users. Legal (not scheduled) NPS were more used than comparable illegal ones. Retrospective identification could be useful when prioritizing NPS for clinical routine analysis and when studying NPS epidemiology.
Emotion regulation in 7‐year‐old children with familial high risk for schizophrenia or bipolar disorder compared to controls – The Danish High Risk and Resilience Study – VIA 7, a population‐based cohort study
Authors: Spang Katrine Søborg , Hagstrøm Julie , Ellersgaard Ditte , Christiani Camilla , Hemager Nicoline , Burton Birgitte Klee , Greve Aja Neergaard , Rohr Kirsten , Gantriis Ditte , Vangkilde Signe , Mors Ole , Nordentoft Merete , Obel Carsten , Plessen Kerstin Jessica , Jepsen Jens Richardt Møllegaard , Thorup Anne A. E. 
Published: August 2022

AbstractObjectivesEmotion regulation is a predictor of overall life outcome. Problems of emotion regulation are associated with multiple psychiatric disorders and could be a potential treatment target for improving well‐being and functioning. Children at familial high risk of severe mental illness have a markedly increased risk of various psychopathology and constitute a group at significant risk of emotion regulation problems. Investigations of emotion regulation in children at familial high risk of severe mental illness are sparse.MethodsWe applied an instrument for assessing emotion regulation, the Tangram Emotion Coding Manual (TEC‐M), to a population‐based cohort of 522 7‐year‐old children born to parents diagnosed with either schizophrenia or bipolar disorder and matched controls. The TEC‐M is an ecologically valid, clinician‐rated observational test measure of spontaneous emotion regulation. We aimed to compare emotion regulation between risk groups and to investigate associations between emotion regulation and psychopathology and daily life functioning, and between emotion regulation and an acknowledged questionnaire‐based dysregulation profile.ResultsIn this early developmental phase, we found no between group differences in emotion regulation. We found a significant but weak negative association between emotion regulation and both child psychopathology and the presence of a dysregulation profile on the Child Behavior Checklist and a weak positive association between emotion regulation and current level of functioning.ConclusionsThese findings contribute to the understanding of emotion regulation in familial high‐risk children and further studies of emotion regulation in children at familial high risk of severe mental illness are warranted.
Resistance to Bruton tyrosine kinase inhibition in chronic lymphocytic leukaemia and non‐Hodgkin lymphoma
Authors: Nakhoda Shazia , Vistarop Aldana , Wang Y. Lynn 
Published: August 2022

SummaryBruton tyrosine kinase inhibitors (BTKi) have transformed the therapeutic landscape of chronic lymphocytic leukaemia (CLL) and non‐Hodgkin lymphoma. However, primary and acquired resistance to BTKi can be seen due to a variety of mechanisms including tumour intrinsic and extrinsic mechanisms such as gene mutations, activation of bypass signalling pathways and tumour microenvironment. Herein, we provide an updated review of the key clinical data of BTKi treatment in CLL, mantle cell lymphoma, and diffuse large B‐cell lymphoma (DLBCL). We incorporate the most recent findings regarding mechanisms of resistance to covalent and non‐covalent inhibitors, including ibrutinib, acalabrutinib, zanubrutinib and pirtobrutinib. We also cover the clinical sensitivity of certain molecular subtypes of DLBCL to an ibrutinib‐containing regimen. Lastly, we summarise ongoing clinical investigations aimed at overcoming resistance via use of BTKi‐containing combined therapies or the novel non‐covalent BTKi. The review article targets an audience of clinical practitioners, clinical investigators and translational researchers.
Impact of human leukocyte antigen mismatch on outcomes after unrelated bone marrow transplantation in paediatric patients: A retrospective analysis by the JSTCT HLA working group
Authors: Kato Itaru , Sakaguchi Hirotoshi , Kato Shunichi , Sato Maho , Noguchi Maiko , Yoshida Nao , Koh Katsuyoshi , Koike Takashi , Yanagimachi Masakatsu , Kato Keisuke , Takahashi Yoshiyuki , Fujita Naoto , Sato Atsushi , Hashii Yoshiko , Tabuchi Ken , Atsuta Yoshiko , Morishima Satoko , Kanda Junya 
Published: August 2022

SummaryThe impact of human leukocyte antigen (HLA) mismatching at the HLA‐A, ‐B, ‐C, and ‐DRB1 loci after unrelated bone marrow transplantation in paediatric patients with haematological malignancies has not been fully examined. Here, we analysed patients with haematological malignancies (all aged ≤15 years; n = 1330) who underwent a first unrelated bone marrow transplantation between 1993 and 2017 in Japan. The results show that although an HLA mismatch was significantly associated with a low relapse rate, it was also associated with higher non‐relapse mortality. There was a significant association between HLA mismatch and low overall survival. Locus mismatch analysis revealed that, as in adults, an HLA‐C mismatch had a significant negative impact on survival; however, in paediatric patients, an HLA‐DRB1 mismatch did not have a negative impact, although these HLA mismatch effects are weakened in recent cases. Taken together, the results suggest that an HLA‐matched donor should be the first candidate for paediatric patients; however, for patients without a matched sibling or matched unrelated donor, we can select an unrelated donor with a mismatch at HLA‐DRB1 if available.
When stakeholders claim differently for diversity management: Adopting lesbian, gay and bisexual‐inclusive practices in Italy
Authors: Pulcher Simone , Guerci Marco , Köllen Thomas 
Published: August 2022

AbstractIn the United States, the adoption of lesbian, gay and bisexual (LGB)‐inclusive practices by companies is triggered primarily by pressures from activists who base their claims on a business case rationale for diversity; this has been studied mainly from a social movement perspective. In Europe, by contrast, diverse actors—not necessarily constituting a unified social movement—make a variety of arguments for more inclusion, based on a spectrum of rationales. To account for this variety, this article adopts a stakeholder approach, identifying two processes through which 14 ‘pioneering’ Italian business organizations have adopted such practices: a business‐driven process and an equality‐driven process. This article demonstrates how these processes are mutually exclusive, and how they differ in terms of rationales, actors involved and outcomes achieved.
Corporate codes of conduct and labour turnover in global apparel supply chains
Authors: Li Chunyun , Kuruvilla Sarosh 
Published: August 2022

AbstractResearch on private regulation of labour issues in global supply chains has focused extensively on whether supplier factories comply with the codes of conduct of global companies. Less is known about how such compliance relates to the preferences and behaviours of workers at export factories. This study analyses a unique dataset of factory audits matched with a survey of worker turnover rates from 622 factories in 28 countries supplying a large global apparel retailer. The results show that violations of the retailer's codes of conduct for suppliers are generally related to turnover, but that workers ‘vote with their feet’ primarily for violations of wages and benefits, relative to violations of other code provisions such as environment protection and safety standards. This ‘means‐ends’ decoupling between factory practices and worker preferences implies that global firms need to incorporate the livelihood logic that underlies workers' turnover decisions while implementing their private regulation programmes.
Connective tissue disease and sarcoidosis: a true association or a secondary granulomatous reaction?
Authors: Steele Lloyd , Bickerstaff Maria , Jeetle Sharanpal , Sahota Anshoo , Maruthappu Thiviyani , Cunningham Malvina 
Published: August 2022

Abstract
Sarcoidosis occurs much more commonly in cohorts of connective tissue disease (1%) compared to the general population (0.01–0.04%). We present a case of concomitant connective tissue disease and cutaneous sarcoidal granulomas and discuss whether the observed granulomas represent a reactive phenomenon or true sarcoidosis.
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A common intronic single nucleotide variant modifies PKD1 expression level
Authors: Zhang Zhengmao , Blumenfeld Jon , Ramnauth Andrew , Barash Irina , Zhou Pengbo , Levine Daniel , Parker Thomas , Rennert Hanna 
Published: August 2022

AbstractAutosomal dominant polycystic kidney disease (ADPKD), caused by mutations in PKD1 and PKD2 (PKD1/2), has unexplained phenotypic variability likely affected by environmental and other genetic factors. Approximately 10% of individuals with ADPKD phenotype have no causal mutation detected, possibly due to unrecognized risk variants of PKD1/2. This study was designed to identify risk variants of PKD genes through population genetic analyses. We used Wright's F‐statistics (Fst) to evaluate common single nucleotide variants (SNVs) potentially favored by positive natural selection in PKD1 from 1000 Genomes Project (1KG) and genotyped 388 subjects from the Rogosin Institute ADPKD Data Repository. The variants with >90th percentile Fst scores underwent further investigation by in silico analysis and molecular genetics analyses. We identified a deep intronic SNV, rs3874648G> A, located in a conserved binding site of the splicing regulator Tra2‐β in PKD1 intron 30. Reverse‐transcription PCR (RT‐PCR) of peripheral blood leukocytes (PBL) from an ADPKD patient homozygous for rs3874648‐A identified an atypical PKD1 splice form. Functional analyses demonstrated that rs3874648‐A allele increased Tra2‐β binding affinity and activated a cryptic acceptor splice‐site, causing a frameshift that introduced a premature stop codon in mRNA, thereby decreasing PKD1 full‐length transcript level. PKD1 transcript levels were lower in PBL from rs3874648‐G/A carriers than in rs3874648‐G/G homozygotes in a small cohort of normal individuals and patients with PKD2 inactivating mutations. Our findings indicate that rs3874648G > A is a PKD1 expression modifier attenuating PKD1 expression through Tra2‐β, while the derived G allele advantageously maintains PKD1 expression and is predominant in all subpopulations.
Biallelic frameshift variant in the TBC1D2B gene in two siblings with progressive gingival overgrowth, fibrous dysplasia of face, and mental deterioration
Authors: Correia‐Costa Gabriela Roldão , de Leeuw Nicole , Pfundt Rolph , Sgardioli Ilária Cristina , dos Santos Ana Paula , de Lima Santos Marilza , Gil‐da‐Silva‐Lopes Vera Lúcia , Vieira Társis Paiva 
Published: August 2022

AbstractBiallelic loss‐of‐function variants in the TBC1D2B gene were recently reported as a cause of a neurodevelopmental disorder with seizures and gingival overgrowth. Here, we report two male siblings with the similar clinical characteristics. They started with gingival overgrowth and bilateral growth of soft tissues in the malar region at 3 years of age, which evolved with significant maxillary hypertrophy and compression of the brainstem due to fibrous dysplasia of facial bones. After disease evolution, they presented with mental deterioration, limb tremors, and gait ataxia. One of them also presented with seizures. Whole exome sequencing revealed a novel biallelic frameshift variant [c.595del; p.(Val199Trpfs*22)] in the TBC1D2B gene in both patients, which was confirmed and found in heterozygous state in each of their parents. There are strong similarities in clinical characteristics, age of onset, and evolution between the patients described here and cases reported in the literature, including cherubism‐like phenotype with progressive gingival overgrowth and seizures. This is the fourth family in the world in which a biallelic loss‐of‐function variant in the TBC1D2B gene is associated with this phenotype. These results support that loss of TBC1D2B is the cause of this rare condition.
Improved surgical outcomes following simultaneous pancreas‐kidney transplantation in the contemporary era
Authors: Sharda Berjesh , Jay Colleen L. , Gurung Komal , Harriman David , Gurram Venkat , Farney Alan C. , Orlando Giuseppe , Rogers Jeffrey , Garner Matthew , Stratta Robert J. 
Published: August 2022

AbstractBackgroundComplications leading to early technical failure have been the Achilles’ heel of simultaneous pancreas‐kidney transplantation (SPKT). The study purpose was to analyze longitudinally our experience with early surgical complications following SPKT with an emphasis on changes in practice that improved outcomes in the most recent era.Study designSingle center retrospective review of all SPKTs from 11/1/01 to 8/12/20 with enteric drainage. Early relaparotomy was defined as occurring within 3 months of SPKT. Patients were stratified into two sequential eras: Era 1 (E1): 11/1/01–5/30/13; Era 2 (E2) 6/1/13–8/12/20 based on changes in practice that occurred pursuant to donor age and pancreas cold ischemia time (CIT).Results255 consecutive SPKTs were analyzed (E1, n = 165; E2, n = 90). E1 patients received organs from older donors (mean E1 27.3 vs. E2 23.1 years) with longer pancreas cold CITs) (mean E1 16.1 vs. E2 13.3 h, both p < .05). E1 patients had a higher early relaparotomy rate (E1 43.0% vs. E2 14.4%) and were more likely to require allograft pancreatectomy (E1 9.1% vs. E2 2.2%, both p < .05). E2 patients underwent systemic venous drainage more frequently (E1 8% vs. E2 29%) but pancreas venous drainage did not influence either relaparotomy or allograft pancreatectomy rates. The most common indications for early relaparotomy in E1 were allograft thrombosis (11.5%) and peri‐pancreatic phlegmon/abscess (8.5%) whereas in E2 were thrombosis, pancreatitis/infection, and bowel obstruction (each 3%).ConclusionMaximizing donor quality (younger donors) and minimizing pancreas CIT are paramount for reducing early surgical complications following SPKT.
Perfusion and oxygenation in allografts with transplant renal artery stenosis: Evaluation with functional magnetic resonance imaging
Authors: Li Xue , Wang Wei , Cheng Dongrui , Yu Yuanmeng , Wu Qianqian , Ni Xuefeng , Chen Jinsong , Zhang Longjiang , Wen Jiqiu 
Published: August 2022

AbstractBackgroundTransplant renal artery stenosis (TRAS) has been shown to reduce kidney perfusion leading to post‐operative hypertension. We aimed to measure the perfusion and oxygenation changes in TRAS with arterial spin labeling (ASL) and blood oxygen level‐dependent (BOLD) imaging, respectively.MethodsIn this single‐center prospective study, a total of seven patients with TRAS and seven age‐ and sex‐matched normal kidney transplant recipients underwent both ASL and BOLD imaging. Moreover, measurements of ASL and BOLD were also performed in five patients after successful angioplasty for TRAS.ResultsAllograft cortical perfusion as measured by ASL in the TRAS group was significantly decreased as compared with normal control group (129.9 ± 46.6 ml/100 g vs. 202.4 ± 47.7 ml/100 g, P = .01). Interestingly, allograft oxygenation as indicated by R2* derived from BOLD in both the cortex (16.42 ± 1.90 Hz vs. 18.25 ± 4.34 Hz, P = .33) and the medulla (30.34 ± 2.35 Hz vs. 30.43 ± 6.85 Hz, P = .97) showed no statistical difference between the TRAS and normal control group. In addition, both cortical and medullary oxygenation remained unchanged despite significantly improved cortical perfusion in those undergone successful angioplasty.ConclusionCortical and medullary oxygenation were preserved in the presence of reduced allograft perfusion in clinically significant TRAS. Prospective larger studies are needed to conclusively establish perfusion and oxygenation changes in TRAS.
1030. AESCULUS CHINENSIS: Sapindaceae
Authors: Christenhusz Maarten J. M. , Yamanaka Masumi 
Published: August 2022

SummaryThe Chinese horse‐chestnut, Aesculus chinensis, is illustrated from a tree cultivated at the Royal Botanic Gardens, Kew. This tree was grown from seeds originally imported from China by Dr Purdom, from whom Kew obtained a plant. A detailed description accompanies this excellent illustration. The taxonomy, ecology, cytology and etymology are also discussed. The introduction of this species into western horticulture and methods of propagation and cultivation are given.
1038. IRIS JUNONIA: Iridaceae
Authors: Rix Martyn , Güner Adil , Mathew Brian , Barlow Gillian , Brown Andrew 
Published: August 2022

SummaryIris junonia Schott & Kotschy ex Schott, a wonderfully scented tall bearded iris, is illustrated; its ecology is described and its relationship to other bearded irises is discussed.
DISCOVERY, DISTRIBUTION AND CONSERVATION OF THE RARE PARASITIC PLANT SAPRIA HIMALAYANA (RAFFLESIACEAE) IN BHUTAN
Authors: Dorji Rinchen , Phuentsho  , Dechen Ugyen , Gyeltshen  , Samdrup Tshering , Dorji Kinley , Powrel Reta B. , Dorji Phub , Dhimal Krishna P. , Long David G. 
Published: August 2022

SummarySapria himalayana Griff. (Rafflesiaceae) and its biology are described. Its distribution in Bhutan is mapped, taking into account recent records.
HARRIET ANN THISELTON‐DYER (1854–1945) A KEW BOTANICAL ARTIST
Authors: Rix Alison J. 
Published: August 2022

SummaryThe life of Harriet Thiselton‐Dyer (1854–1945) is described briefly and her botanical paintings and contributions to Curtis's Botanical Magazine are assessed. As grand‐daughter, daughter and wife of three directors of Kew, who were also editors of this magazine, her supportive rôle deserves more recognition.
1033. RHODODENDRON STARLINGII: Ericaceae
Authors: Rushforth Keith , Huong Nguyen Thi Thanh , Yamanaka Masumi 
Published: August 2022

SummaryRhododendron starlingii Rushforth & Nguyen Thi Thanh Huong, from Fan Si Pan, Vietnam's highest mountain, is described as a new species and illustrated. It is related to R. crenulatum from Pu Bia, Laos' highest mountain, but differs in several characters.
Longitudinal analysis of users transitioning from the Dexcom G5 to the G6 RT‐CGM system in Germany, Sweden and the United Kingdom (2018–2020)
Authors: Acciaroli Giada , van der Linden Joost , Chao Christy , Walker Tomas C. , Oliver Nick 
Published: August 2022

AbstractAimsRegional variations in the adoption of diabetes technology may be reflected in population‐level metrics of glycaemic control. In this observational study, we aimed to assess the glycaemic impacts of transitioning from the Dexcom G5 Real‐Time Continuous Glucose Monitoring (RT‐CGM) System to the Dexcom G6 in three European countries.MethodsAnonymised RT‐CGM data (uploaded to the Dexcom Clarity app) were from users in Germany, Sweden, and the United Kingdom (UK) who transitioned from G5 to G6 between 9‐12 months after G6 launched in 2018. Primary endpoints were percent time in hypoglycaemia, percent time in range (TIR), user retention rates, device utilisation, and urgent low soon (ULS) alert utilisation. Metrics were computed for 3‐month intervals in the 2‐year study window.ResultsIn all three countries, the transition from G5 to G6 was associated with a clear decrease in hypoglycaemia. In months 0‐3 after transitioning, the median percent time 〈3 mmol/L (54 mg/dL) and 〈3.9 mmol/L (70 mg/dL) decreased by [0.12‐0.28] and [0.40‐0.43] percentage points, respectively, with another [0.11‐0.21] and [0.34‐0.65] percentage point decrease in months 3‐6 in the three countries analysed. TIR and CGM utilisation were sustained or improved slightly across all countries. At the end of the study window, the retention rate was [88.8‐94.8%] and ULS utilization was [83.9‐86.9%] in the three countries analysed.ConclusionsSimilar RT‐CGM trends were observed across Germany, Sweden, and the UK. Improvements in hypoglycaemia occurred in all countries. The high retention of users may lead to sustained glycaemic benefits associated with RT‐CGM use.
The effectiveness of cognitive behavioural therapy and third‐wave cognitive behavioural interventions on diabetes‐related distress: A systematic review and meta‐analysis
Authors: Jenkinson Emma , Knoop Iris , Hudson Joanna L. , Moss‐Morris Rona , Hackett Ruth A. 
Published: August 2022

AbstractAimDiabetes‐related distress is common in diabetes and has implications for well‐being. Cognitive behavioural therapy (CBT) and third‐wave CBT hold promise as treatments for diabetes‐related distress, although previous findings are inconclusive. We aimed to conduct a systematic review with meta‐analysis to understand the efficacy of these interventions in treating diabetes‐related distress, while also assessing the associative benefits of these interventions on depression, anxiety and glycaemic control. We also aimed to conduct a narrative synthesis, and subgroup analyses to identify intervention components most useful in treating diabetes‐related distress.MethodWe searched seven electronic databases from inception to April 2021. Data extraction was independently performed by two reviewers. Methodological quality was assessed. The protocol was registered with the Prospective Register Of Systematic Reviews (PROSPERO): CRD42021240628.ResultsWe included 22 randomised controlled trials investigating the efficacy of CBT and third‐wave CBT interventions on diabetes‐related distress. CBT for diabetes‐related distress significantly reduced distress (SMD = −0.278, p = 0.010) and depression (SMD = −0.604, p = 0.016). Third‐wave CBT for diabetes‐related distress significantly reduced anxiety (SMD = −0.451, p = 0.034). No significant effect of either intervention on glycated haemoglobin was observed. CBT interventions that included a digital component, were delivered by a psychological practitioner, and included behavioural activation bolstered the effects on diabetes‐related distress.ConclusionsCBT aiming to target diabetes‐related distress is beneficial for distress and depression. Third‐wave CBT for diabetes‐related distress is beneficial for anxiety. More work is needed to optimise interventions to improve both mental and physical health outcomes in people with diabetes.