bluuebunny/crossref_metadata_2025_split huggingface dataset:
Yin Yang 1 promotes aggressive cell growth in high‐grade breast cancer by directly transactivating kinectin 1
Authors: Gao Lin , Zhou Wenbin , Xie Ni , Qiu Junying , Huang Jingyi , Zhang Zhe , Hong Malin , Xia Jinquan , Xu Jing , Zhao Pan , Fu Li , Luo Yuwei , Jiang Jing , Gong Hui , Wang Jigang , Dai Yong , Luo Dixian , Zou Chang 
Published: July 2022

AbstractInvasive cancer growth and metastasis account for the poor prognosis of high‐grade breast cancer. Recently, we reported that kinectin 1 (KTN1), a member of the kinesin‐binding protein family, promotes cell invasion of triple‐negative breast cancer and high‐grade breast cancer cells by augmenting the NF‐κB signaling pathway. However, the upstream mechanism regulating KTN1 is unknown. Therefore, this functional study was performed to decipher the regulatory cohort of KTN1 in high‐grade breast cancer. Bioinformatic analysis indicated that transcription factor Yin Yang 1 (YY1) was a potential transactivator of KTN1. High YY1 expression correlated positively with pathological progression and poor prognosis of high‐grade breast cancer. Additionally, YY1 promoted cell invasive growth both in vitro and in vivo, in a KTN1‐dependent manner. Mechanistically, YY1 could transactivate the KTN1 gene promoter. Alternatively, YY1 could directly interact with a co‐factor, DEAD‐box helicase 3 X‐linked (DDX3X), which significantly co‐activated YY1‐mediated transcriptional expression of KTN1. Moreover, DDX3X augmented YY1‐KTN1 signaling‐promoted invasive cell growth of breast cancer. Importantly, overexpression of YY1 enhanced tumor aggressive growth in a mouse breast cancer model. Our findings established a novel DDX3X‐assisted YY1‐KTN1 regulatory axis in breast cancer progression, which could lead to the development novel therapeutic targets for breast cancer.
An experimental and numerical study to enhance the thermal characteristics of LA/CuO/Al2O3 nanocomposites as a phase change material for building cooling applications
Authors: Thangapandian Elangovan , Palanisamy Ponnusamy 
Published: July 2022

AbstractTo improve the thermophysical properties of lauric acid (LA), several loadings of copper oxide(CuO) and aluminum oxide (Al2O3) nanoparticles (1.25, 2.5, 5, and 10 wt%) were used. In this present study, the possibility of varied concentration nanoparticles to create LA embedded nanocomposite phase change material (NPCM) with increased performance is also studied and compared. The analytical expressions for estimating both thermal conductivity (TC) and dynamic viscosity of the NPCM were devised, and the findings were confirmed against the experiment. Employing a computational fluid dynamics (CFD) model, the effects of nanoparticle concentration on LA's rate of melting and solidification are examined. The morphological structures of nanoparticles were seen using a field emission scanning electron microscope (FESEM), and their crystalline structure was determined using X‐ray diffraction (XRD) analysis. Fourier transform infrared spectroscopy (FTIR) was used to verify NPCMs. The impact of nanoparticles on NPCM was demonstrated by the thermal conductivity (KD2 test) findings. The current results suggest that distributing nanoparticles in lower concentrations speeds up the HTR. Compared to copper oxide (CuO) nanoparticles, the enhancement in the thermal performance of LA is more significant for aluminum oxide (Al2O3).
A Nonlinear Ultrasonic Method for Detection and Characterization of Dewetting Damage in Solid Propellant
Authors: Pan Yu , Qu Wen‐Zhong , Zhang Shou‐Cheng , Xiao Li , Chu Xi‐Hua 
Published: July 2022

AbstractThe dewetting damage of solid propellant under loading is a key factor affecting the constitutive properties of solid propellant, and it will weaken structural integrity of solid rocket motor charge. The quantitative characterization of its evolution process has always been a very active research field. In this study, a nonlinear ultrasonic (NLU) method is proposed to investigate and monitor in real‐time the nonlinear dynamic response of solid propellant. The NLU parameter, which can evolve dewetting damage, is expressed by some physical quantities such as the frequency peak, the propagation distance and so on, and is recorded at different strain in the tensile tests of the round rod solid propellant specimens. Then, the initial dewetting point, characteristic dewetting point and characteristic dewetting rate are defined to characterize the dewetting performance. The results show that NLU parameter changes continuously with the evolution of tensile process and increases sharply at the initial dewetting damage point. By analyzing the data, an empirical formula characterizing the variation law of NLU parameter with strain is proposed, which is well fitted to the experimental data under different strain rates. In addition, relevant numerical simulation is carried out, and the simulation results verify the feasibility of the NLU method.
A novel prognostic model predicting overall survival in patients with metastatic castration‐resistant prostate cancer receiving standard chemotherapy: A multi‐trial cohort analysis
Authors: Modonutti Daniele , Majdalany Sami E. , Corsi Nicholas , Li Pin , Sood Akshay , Dalela Deepansh , Jamil Marcus L. , Hwang Clara , Menon Mani , Rogers Craig G. , Trinh Quoc‐Dien , Novara Giacomo , Abdollah Firas 
Published: July 2022

AbstractPurposeGeneralizable, updated, and easy‐to‐use prognostic models for patients with metastatic castration‐resistant prostate cancer (mCRPC) are lacking. We developed a nomogram predicting the overall survival (OS) of mCRPC patients receiving standard chemotherapy using data from five randomized clinical trials (RCTs).MethodsPatients enrolled in the control arm of five RCTs (ASCENT 2, VENICE, CELGENE/MAINSAIL, ENTHUSE 14, and ENTHUSE 33) were randomly split between training (n = 1636, 70%) and validation cohorts (n = 700, 30%). In the training cohort, Cox regression tested the prognostic significance of all available variables as a predictor of OS. Independent predictors of OS on multivariable analysis were used to construct a novel multivariable model (nomogram). The accuracy of this model was tested in the validation cohort using time‐dependent area under the curve (tAUC) and calibration curves.ResultsMost of the patients were aged 65–74 years (44.5%) and the median (interquartile range) follow‐up time was 13.9 (8.9–20.2) months. At multivariable analysis, the following were independent predictors of OS in mCRPC patients: sites of metastasis (visceral vs. bone metastasis, hazard ratio [HR]: 1.24), prostate‐specific antigen (HR: 1.00), aspartate transaminase (HR: 1.01), alkaline phosphatase (HR: 1.00), body mass index (HR: 0.97), and hemoglobin (≥13 g/dl vs. <11 g/dl, HR: 0.41; all p < 0.05). A nomogram based on these variables was developed and showed favorable discrimination (tAUC at 12 and 24 months: 73% and 72%, respectively) and calibration characteristics on external validation.ConclusionA new prognostic model to predict OS of patients with mCRPC undergoing first line chemotherapy was developed. This can help urologists/oncologists in counseling patients and might be useful to better stratify patients for future clinical trials.
Nervous habitat patches: The effect of hydropeaking on habitat dynamics
Authors: Bätz Nico , Judes Clarisse , Weber Christine 
Published: July 2022

AbstractAlteration in the river flow regime due to intermittent hydropower production (i.e., hydropeaking) leads to biodiversity loss and ecosystem degradation worldwide. Due to the increasing shear of volatile green energy (i.e., wind and solar), hydropeaking frequency is deemed to increase in the coming decades. However, our mechanistic understanding of how the frequency of repeated hydropeaking (i.e., series of multiple events) affects ecological processes is still limited. Here, we reflect on the impacts of altered flow frequency and relative duration on the persistency of aquatic habitats. We focus on the habitats at patch‐scale, being this the scale representing what organisms perceive when interacting with their environment. With a showcase we explore a temporally explicit approach to quantify altered habitat dynamics at patch‐scale due to hydropeaking. We then review how changes in habitat dynamics and persistency may affect ecological processes. Our findings suggest that (i) a time‐series approach allows to account for the inherent multi‐event nature of hydropeaking; (ii) hydropeaking can increase the dynamics of single habitat patches by at least one order of magnitude if compared to unregulated rivers; (iii) altered habitat dynamics at the patch scale can affect the survival of more sessile species and life cycle stages (e.g., invertebrates) or the energy budget of mobile species and life cycle stages (e.g., adult fish). However, the ecological significance and potential environmental thresholds of patch‐scale dynamics and persistency are still poorly investigated and need further attention. Moreover, methods for the aggregation of habitat dynamics and persistency from the patch to the reach‐scale are not available yet.
A New XGBoost Inference with Boundary Conditions in Real Estate Price Prediction
Authors: Iwai Koichi , Hamagami Tomoki 
Published: July 2022

AbstractReal estate price prediction takes an important role in the economy that can drive up and down the stock prices and even generate disruptive economic events. Many researchers have tried to understand the pricing mechanism with machine learning techniques such as support vector machine, neural network, random forest, and AdaBoost. The boundary problem, on the other hand, makes the pricing scheme more complicated, and this trend is accelerated especially in the situation of population decline in Japan. In this paper, we discuss how we could approach the boundary problem in real estate prediction. We propose a new comprehensive inference model extending and adapting XGBoost to the domain that has the boundary conditions problem by utilizing the distance between the instances in the domain data set to make the layers of bumpy boundaries smooth for more accurate predictions and robustness against the domain data set. The experiments result showed our proposed method performed well on both hypothetical data sets and actual real estate price data. © 2022 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.
Disjointness through the Lens of Vapnik–Chervonenkis Dimension: Sparsity and Beyond
Authors: Bhattacharya Anup , Chakraborty Sourav , Ghosh Arijit , Mishra Gopinath , Paraashar Manaswi 
Published: July 2022

AbstractThe disjointness problem—where Alice and Bob are given two
subsets of $$\{1, \dots, n\}$$

{
1
,
⋯
,
n
}

and they have to check if their sets
intersect—is a central problem in the world of communication
complexity. While both deterministic and randomized communication
complexities for this problem are known to be $$\Theta(n)$$

Θ
(
n
)

, it is
also known that if the sets are assumed to be drawn from some
restricted set systems then the communication complexity can be much
lower. In this work, we explore how communication complexity
measures change with respect to the complexity of the underlying set
system. The complexity measure for the set system that we use in
this work is the Vapnik—Chervonenkis (VC) dimension. More
precisely, on any set system with VC dimension bounded by d, we
analyze how large can the deterministic and randomized communication
complexities be, as a function of d and n. The d-sparse set
disjointness problem, where the sets have size at most d, is one
such set system with VC dimension d. The deterministic and the
randomized communication complexities of the d-sparse set
disjointness problem have been well studied and are known to be
$$\Theta \left( d \log \left({n}/{d}\right)\right)$$

Θ

d
log

n
/
d

and $$\Theta(d)$$

Θ
(
d
)

,
respectively, in the multi-round communication setting. In this
paper, we address the question of whether the randomized
communication complexity of the disjointness problem is always upper
bounded by a function of the VC dimension of the set system, and
does there always exist a gap between the deterministic and
randomized communication complexities of the disjointness problem
for set systems with small VC dimension.We construct two natural set systems of VC dimension d, motivated
from geometry. Using these set systems, we show that the deterministic and
randomized communication complexity can be $$\widetilde{\Theta}\left(d\log \left( n/d \right)\right)$$

Θ
~

d
log

n
/
d

for set systems of
VC dimension d and this matches the deterministic upper bound for all set
systems of VC dimension d. We also study the deterministic and randomized
communication complexities of the set intersection problem when sets belong to a set
system of bounded VC dimension. We show that there exist set systems of
VC dimension d such that both deterministic and randomized (one-way and
multi-round) complexities for the set intersection problem can be as high
as $$\Theta\left( d\log \left( n/d \right) \right)$$

Θ

d
log

n
/
d

.
Ischemic Lesion Growth in Patients with a Persistent Target Mismatch After Large Vessel Occlusion
Authors: Tomari Shinya , Lillicrap Thomas , Garcia-Esperon Carlos , Kashida Yumi Tomari , Bivard Andrew , Lin Longting , Levi Christopher R. , Spratt Neil J. 
Published: July 2022

Abstract
Background
Failure to reperfuse a cerebral occlusion resulting in a persistent penumbral pattern has not been fully described.

Methods
We retrospectively reviewed patients with anterior large vessel occlusion who did not receive reperfusion, and underwent repeated perfusion imaging, with baseline imaging < 6 h after onset and follow-up scans from 16–168 h. A persistent target mismatch (PTM) was defined as core volume of < 100 mL, mismatch ratio > 1.2, and mismatch volume > 10 mL on follow-up imaging. Patients were divided into PTM or non-PTM groups. Ischemic core and penumbral volumes were compared between baseline and follow-up imaging between the two groups, and collateral flow status assessed using CT perfusion collateral index.

Results
A total of 25 patients (14 PTM and 11 non-PTM) were enrolled in the study. Median core volumes increased slightly in the PTM group, from 22 to 36 ml. There was a much greater increase in the non-PTM group, from 57 to 190 ml. Penumbral volumes were stable in the PTM group from a median of 79 ml at baseline to 88 ml at follow-up, whereas penumbra was reduced in the non-PTM group, from 120 to 0 ml. Collateral flow status was also better in the PTM group and the median collateral index was 33% compared with 44% in the non-PTM group (p = 0.043).

Conclusion
Multiple patients were identified with limited core growth and large penumbra (persistent target mismatch) > 16 h after stroke onset, likely due to more favorable collateral flow.
Protein kinase Ime2 is associated with mycelial growth, conidiation, osmoregulation, and pathogenicity in Fusarium oxysporum
Authors: Xiao Jiling , Zhang Yi , Yang Ke , Tang Yanying , Wei Lin , Liu Erming , Liang Zhihuai 
Published: July 2022

AbstractFusarium oxysporum f.sp. niveum is one of the most serious diseases impairing watermelon yield and quality. Inducer of meiosis 2 (Ime2) is the founding member of a family of serine/threonine protein kinases and plays important roles in yeasts and other filamentous fungi. In this study, we analyzed the functions of FoIme2, the ortholog of Saccharomyces cerevisiae Ime2 in F. oxysporum f.sp. niveum. The FoIme2-deleted mutants exhibited obvious morphological abnormalities, including slower vegetative growth, more branches in the edge hyphae and a reduction in conidia production. Compared to the wild type, the mutants were hypersensitive to the osmotic stressor NaCl but were more insensitive to the membrane stressor SDS. The deletion of FoIme2 also caused a reduction in pathogenicity. Transcriptional analysis revealed that FoIme2 acts downstream of FoOpy2 which is an upstream sensor of the MAPK kinase cascade. These results indicate that FoIme2 is important in the development and pathogenicity of F. oxysporum, and provide new insight for the analysis of the pathogenic mechanism of F. oxysporum.
Hidden Spectral Symmetries and Mode Stability of Subextremal Kerr(-de Sitter) Black Holes
Authors: Casals Marc , Teixeira da Costa Rita 
Published: July 2022

AbstractWe uncover hidden spectral symmetries of the Teukolsky equation in Kerr(-de Sitter) black holes, recently conjectured by Aminov, Grassi and Hatsuda (Ann. Henri Poincaré 23, 1951-1977, 2022, and Gen. Relativ. Grav. 53(10):93, 2021) in the zero cosmological constant case. Using these symmetries, we provide a new, simpler proof of mode stability for subextremal Kerr black holes. We also present a partial mode stability result for Kerr–de Sitter black holes.
The Challenges Experienced By Female Surgeons in Africa: A Systematic Review
Authors: Jesuyajolu Damilola Alexander , Okeke Charles Arinze , Obuh Otomi 
Published: July 2022

AbstractBackgroundThere are many challenges faced by female surgeons in Africa. These challenges, when brought to the forefront, can be tackled by the necessary stakeholders to increase the participation of women in surgery. This paper will review the existing literature, across the African continent, to bring to light the challenges experienced by women currently practicing as surgeons.MethodsWe conducted a search using keywords ‘Challenges’ ‘Female’ ‘Surgeon’ ‘Africa’ and ‘Bias’ on PubMed, Google Scholar, and AJOL from inception till the 21st of January 2022. We then searched the same keywords on the Google search engine in addition to the names of each of the 54 African countries.ResultsWe followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) in conducting this systematic review. Out of the 10 published papers that were deemed eligible, four (n = 4) originated from South Africa. Other countries that were represented include Nigeria, Rwanda, Zimbabwe and Ghana. 8 of the articles were cross‐sectional studies. Underrepresentation was the most common challenge (n = 4 articles). Disrespect from colleagues, poor work‐life balance, harassment, and stereotypes were also challenges identified in these articles.ConclusionDespite the increasing participation, female surgeons continue to face different challenges ranging from the unfavorable work environment to the pressures put on them by society. This narrative review serves as a stimulant for major health stakeholders in Global surgery to promote gender inclusivity in the African surgical workforce.
Bindungsdimensionen im Erwachsenenalter – beziehungsspezifische Unterschiede und ihre Zusammenhänge mit psychischer Gesundheit
Authors: Flemming Eva , Lübke Laura , Müller Sascha , Lorenzen Vera , Spitzer Carsten 
Published: July 2022

Zusammenfassung
Hintergrund
Empirische Befunde legen nahe, dass Bindung im Erwachsenenalter sowohl globale als auch beziehungsspezifische Aspekte aufweist. Bisher ist jedoch nicht ausreichend geklärt, inwieweit sich globale und spezifische Bindungsdimensionen in ihren Zusammenhängen mit psychischer Gesundheit unterscheiden.

Methodik
In einer Gelegenheitsstichprobe (n = 622; 86 % weiblich, Altersdurchschnitt 33 Jahre) wurden Bindungsangst und Bindungsvermeidung jeweils in den Beziehungen zu Mutter, Vater, PartnerIn und FreundIn und in einer globalen Form mittels des Selbstbeurteilungsinstruments Experiences in Close Relationships – Relationship Structures (ECR-RS) erhoben. Es wurde angenommen, dass sich die Ausprägungen der Bindungsdimensionen je nach Beziehungskontext voneinander unterscheiden. Mittels multipler Regression wurden die Zusammenhänge der Skalen des ECR-RS mit der Symptom-Checklist-Kurzversion (SCL-K9), dem Inventar Interpersonaler Probleme (IIP-32) und der Level of Personality Functioning Scale – Brief Form (LPFS-BF) untersucht.

Ergebnisse
Bindungsangst und Bindungsvermeidung wurden je nach Beziehungskontext unterschiedlich hoch eingeschätzt (Bindungsangst: ηp2 = 0,18, Bindungsvermeidung: ηp2 = 0,31). Globale Bindungsangst war der stärkste Prädiktor für aktuelle psychische Beschwerden (β = 0,48, p < 0,001), interpersonale Probleme (β = 0,49, p < 0,001) und Beeinträchtigungen im Persönlichkeitsfunktionsniveau (β = 0,48, p < 0,001). Globale Bindungsvermeidung zeigte keinen wesentlichen inkrementellen Effekt über die beziehungsspezifische Vermeidung hinaus. Hingegen stand insbesondere Bindungsvermeidung in der Partnerschaft mit den 3 Ergebnismaßen im Zusammenhang.

Diskussion
Die Bindungsdimensionen von Erwachsenen scheinen sich je nach dem Beziehungskontext, in dem sie beurteilt werden, zu unterscheiden. Für die Praxis könnte eine Kombination aus globalen und partnerschaftsbezogenen Bindungsfragebogen am aussagekräftigsten sein, um die unterschiedlichen Zusammenhänge von Bindungsangst und Bindungsvermeidung mit der psychischen Gesundheit ausreichend zu erfassen.
Effect of mindfulness yoga on anxiety and depression in early breast cancer patients received adjuvant chemotherapy: a randomized clinical trial
Authors: Liu Weimin , Liu Juan , Ma Lan , Chen Jing 
Published: July 2022

Abstract
Purpose
The objective of this study is to explore the effects of a mindfulness yoga treatment on emotional disorders, fatigue, pain, and health-related quality of life in early-stage breast cancer patients.

Methods
The eligible 136 participants were randomly assigned 1:1 to the experimental group (mindfulness yoga + conventional care) and the control group (conventional care). The hospital anxiety and depression scale was used to assess anxiety and depression symptoms as the primary outcome. Secondary results comprised fatigue (RPFS-CV), pain (BPI-C), and health-related quality of life (FACT-B). Assessments were performed at baseline time, the 8th week, and the 20th week.

Results
The Experimental group had a better prognosis in comparison with those in the control group, especially for anxiety [inter-group effect, T1: 1.18 (95% CI 0.20–2.17; P = 0.018)], depression [T1: 1.49 (95% CI 0.48–2.50; P = 0.004)] and health-related life quality [T1: − 6.34 (95% CI − 11.81 to − 0.87; P = 0.023)]. While fatigue [T1: 0.23 (95% CI − 0.24–0.69; P = 0.337); T2: 0.27 (95% CI − 0.16–0.71; P = 0.219)] and pain [T1: 1.11 (95% CI − 0.05–2.27; P = 0.060); T2: 0.68 (95% CI − 0.27–1.62; P = 0.159)] were not different between the two groups.

Conclusion
In patients with early-stage breast cancer who had received adjuvant chemotherapy, treatment with mindfulness yoga is as effective as conventional care in improving physical function. Along with other treatments, mindfulness yoga may help alleviate anxiety and depression to improve the overall physical and mental health and quality of life of early-stage breast cancer patients.
Chinese Clinical Trial Registry Registration number: ChiCTR2100052842, Reg. Date: 2021/11/6.
Brief report: community-acquired Friedlander’s pneumonia and pulmonary metastatic Klebsiella pneumoniae infection caused by hypervirulent ST23 in the Netherlands
Authors: Fliss Monika , van den Berg Charlotte H. S. B. , Kuijper Ed , Notermans Daan W. , Hendrickx Antoni P. A. , Schoots Mirthe H. , Bathoorn Erik 
Published: July 2022

Abstract
Infections with hypervirulent Klebsiella pneumoniae (hvKp) commonly presents with primary liver infection, bacteremia, and metastatic abscesses. Here, we present 2 cases of severe community-acquired pulmonary infections by hvKp in patients in the Netherlands without recent travel history. Both bacterial isolates are closely related to an archetype ST23 hvKp reference isolate. Based on these findings, surveillance programs on hvKp may consider to include isolates from community-acquired pneumonia by K. pneumoniae.