bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reassessing the Benefits and Harms of Risk-Reducing Medication Considering the Persistent Risk of Breast Cancer Mortality in Estrogen Receptor–Positive Breast Cancer
Authors: Jayasekera Jinani , Zhao Amy , Schechter Clyde , Lowry Kathryn , Yeh Jennifer M. , Schwartz Marc D. , O'Neill Suzanne , Wernli Karen J. , Stout Natasha , Mandelblatt Jeanne , Kurian Allison W. , Isaacs Claudine 
Published: December 2022

PURPOSE Recent studies, including a meta-analysis of 88 trials, have shown higher than expected rates of recurrence and death in hormone receptor–positive breast cancer. These new findings suggest a need to re-evaluate the use of risk-reducing medication to avoid invasive breast cancer and breast cancer death in high-risk women. METHODS We adapted an established Cancer Intervention and Surveillance Modeling Network model to evaluate the lifetime benefits and harms of risk-reducing medication in women with a ≥ 3% 5-year risk of developing breast cancer according to the Breast Cancer Surveillance Consortium risk calculator. Model input parameters were derived from meta-analyses, clinical trials, and large observational data. We evaluated the effects of 5 years of risk-reducing medication (tamoxifen/aromatase inhibitors) with annual screening mammography ± magnetic resonance imaging (MRI) compared with no screening, MRI, or risk-reducing medication. The modeled outcomes included invasive breast cancer, breast cancer death, side effects, false positives, and overdiagnosis. We conducted subgroup analyses for individual risk factors such as age, family history, and prior biopsy. RESULTS Risk-reducing tamoxifen with annual screening (± MRI) decreased the risk of invasive breast cancer by 40% and breast cancer death by 57%, compared with no tamoxifen or screening. This is equivalent to an absolute reduction of 95 invasive breast cancers, and 42 breast cancer deaths per 1,000 high-risk women. However, these drugs are associated with side effects. For example, tamoxifen could increase the number of endometrial cancers up to 11 per 1,000 high-risk women. Benefits and harms varied by individual characteristics. CONCLUSION The addition of risk-reducing medication to screening could further decrease the risk of breast cancer death. Clinical guidelines for high-risk women should consider integrating shared decision making for risk-reducing medication and screening on the basis of individual risk factors.
TRANSPORTATION OF COAL BY SEA AND RISKS ASSOCIATED WITH ITS TRANSPORTATION
Authors: Nikolashin Sergey Yu. , Khabirov Timur R. 
Published: December 2022

Maritime and maritime transport is a vital component of the global economy and transport network. The number of people, firms and organizations using shipping is growing worldwide. As with other transport systems, safety is critical in maritime transport. Because ship emergency processes are very different from emergency evacuation processes from buildings and other vehicles and are more complex, many researchers have published a wide range of documents relevant to this specific area of research.
In recent decades, marine accidents have attracted a lot of attention due to huge material damage, accidents and serious environmental pollution. Maritime transport can include unforeseen events resulting in catastrophic casualties as well as fatal injuries at sea. About 63% of shipping accidents in the world are recurring. In other words, they arise with courts that have already survived at least one previous accident. In this case, emergency management plans are recognized as a priority for prompt consideration, taking into account the potential consequences of natural disasters in the marine industry.
The article discusses the issues of coal transportation by sea and requirements regarding the safe laying and transportation of coal. Unsafe transportation can lead to appropriate risks on board, such as structural damage iz-za improper distribution of coal, chemical reaction leading to spontaneous combustion, release of explosive gases and liquefaction.
Since coal is subject to liquefaction, a number of precautions and procedures without precautions and follow procedures for safe loading and transportation.
Purpose. The goal is to analyze coal as a dangerous cargo, and the risks associated with its transportation.
Methodology the article used statistical methods of analysis and factor method of coal liquefaction.
Results: parameters of comparison of coal particles, for its safe transportation.
Practical implications it is advisable to apply the obtained results when transporting general goods by sea.
Cyclic visualization of the respiratory stages in teaching human physiology to english-speaking students
Authors: Povar M. , Tkachuk S. , Yasinska O. 
Published: December 2022

In the course of Human Physiology, students of different specialties learn cyclic processes reflecting the work of the cardiovascular, respiratory, female reproductive systems and sleep as well. Visualization of the cyclic processes is essential for better understanding of the organization and functioning of these systems and finding pathological deviations with formation of defective cycles.
The objective of the work is to analyze the application of the visualization of the respiratory stages into the educational process. Dynamics of the physiological processes at various stages of respiration with the help of schematic visual figures allows effective formation of the students’ systemic understanding of the respiratory system functions and its interrelations with the cardiovascular system. These enable to apply the acquired theoretical knowledge while solving clinical situational tasks and formation of professional competence.
Conservadurismo, clasismo y racismo: Nuevo orden (2020) un análisis ideológico
Authors: Frías Gamez Luis Gerardo 
Published: December 2022

Nuevo orden (2020) es una película de ficción reconocida en diversos festivales internacionales de cine por su narrativa y propuesta estética. Sin embargo, la crítica cinematográfica señaló la presencia de un discurso clasista y racista. A partir de estas observaciones surge el objetivo de analizar el discurso ideológico referente al racismo y el clasismo representado en la película a partir de dos personajes masculinos pertenecientes a diferentes clases sociales. Para realizar este análisis textual se emplea el método de Van Dijk (1998) para describir las ideologías de los grupos sociales a partir de la observación de la puesta en escena. Entre los resultados se encuentra que ambos personajes comparten algunas características físicas y características sociales como heterosexualidad, religión y deseos de mantener el statu quo. No obstante, se encuentran diferencias en cuanto a la posición social, rasgos raciales y comportamiento. Por último, se confirman las observaciones en cuanto a la presencia de elementos racistas, pero también se aprecia una crítica hacia la burguesía por su falta de reciprocidad hacia la clase dominada, así como la reproducción de prácticas como el influyentismo y la subordinación de las mujeres.
An Accelerated Newton–Dinkelbach Method and Its Application to Two Variables per Inequality Systems
Authors: Dadush Daniel , Koh Zhuan Khye , Natura Bento , Végh László A. 
Published: December 2022

We present an accelerated or “look-ahead” version of the Newton–Dinkelbach method, a well-known technique for solving fractional and parametric optimization problems. This acceleration halves the Bregman divergence between the current iterate and the optimal solution within every two iterations. Using the Bregman divergence as a potential in conjunction with combinatorial arguments, we obtain strongly polynomial algorithms in three applications domains. (i) For linear fractional combinatorial optimization, we show a convergence bound of [Formula: see text] iterations; the previous best bound was [Formula: see text] by Wang, Yang, and Zhang from 2006. (ii) We obtain a strongly polynomial label-correcting algorithm for solving linear feasibility systems with two variables per inequality (2VPI). For a 2VPI system with n variables and m constraints, our algorithm runs in O(mn) iterations. Every iteration takes O(mn) time for general 2VPI systems and [Formula: see text] time for the special case of deterministic Markov decision processes (DMDPs). This extends and strengthens a previous result by Madani from 2002 that showed a weakly polynomial bound for a variant of the Newton–Dinkelbach method for solving DMDPs. (iii) We give a simplified variant of the parametric submodular function minimization result from 2017 by Goemans, Gupta, and Jaillet. Funding: This project received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme [Grants 757481-ScaleOpt and 805241-QIP].
USINGSTEM (SCIENCE, TECHNOLOGY, ENGINEERING, ARTS, AND MATH) BASED APPROACH IN PROJECT-BASED ENTREPRENEURSHIP EDUCATION AT A TRAINING INSTITUTE
Authors: Mitrev Krassimir 
Published: December 2022

The education system in the 21st century is continuously transforming due to modern trends in human sciences, particularly the accelerated development of pedagogical science. New approaches are required based on the increased quality of education, personality development, the principles of democratic learning, STEM education, current trends in entrepreneurship education. Ensuring quality professional education and training requires compliance with the European and national priorities and policies in this area. In education systems, the requirement for developing social competencies, qualities of taking initiative and entrepreneurship, personal responsibility and special skills related to business and entrepreneurial activity is increasing.
This article presents a model for combining and upgrading traditional entrepreneurship training with STEM-based training and active learning methods in an interactive educational environment. The aim of the research is to develop an innovative model for entrepreneurship education through a training institute, with the application of STEM based integrated activities. For the study the following tasks have been defined: analysis of the current state of the problem in the scientific literature and a study of good European and national practices for entrepreneurship education, analysis of the didactic aspects of entrepreneurship training through a training institute for students aged between 15-19 years, development of an experimental program for extracurricular activity using active methods and an integrated STEM approach, development of variants of interdisciplinary situations and learning projects combined with STEM. Achieve functional literacy, analytical skills and creativity, rapid adaptation to modern technologies and the resulting changes in the labor market. In parallel, the focus is on the formation of interdisciplinary and practically oriented knowledge and problem-solving skills, entrepreneurship, creative and critical thinking, and civic engagement.
WHY NATO-RUSSIA COUNCIL HAS FAILED AFTER 20 YEARS OF EXISTENCE
Authors: Iulian Raluca Iulia 
Published: December 2022

At the end of 2021, Russia mobilised over a hundred thousand soldiers along its border with Ukraine constituting a permanent threat to Ukraine and a concern for the West and the whole world. On February 24, 2022, Russia initiated a military intervention in Ukraine. The Kremlin has decided to reconstitute its border lines of the former USSR (Union of Soviet Socialist Republics) and its spheres of influence in Central and Eastern Europe.
After the end of the Cold War, Russia, a nuclear power, has constantly expressed its desire to have a special status in relation to the North Atlantic Alliance different from that of former communist countries, members of the Warsaw Pact. The NATO-Russia Council (NRC) is the structure in which Russia had that special and unique relationship with NATO. NRC was established in 2002 to resolve any inconsistencies in the NATO-Russia relations, to facilitate a more flexible dialogue, and understanding between the parties and to open new areas of collaboration. However, it could not change the perceptions created during the Cold War, and most importantly, it could not resolve Russia's place and role in Europe's security issues.
From February 24, 2022, the NRC lost its credibility, the policy of dialogue was no longer relevant and NATO switched to the policy of deterrence and collective defense of the entire Eastern flank of NATO.
The study presents the evolution of relations between NATO and Russia, the phases they went through in the last twenty years since the creation of the NRC and explained the failure of NATO-Russia cooperation in NRC.
Surgical approaches for proximal interphalangeal joint arthroplasty
Authors: Renfree Kevin J. 
Published: December 2022

This annotation reviews current concepts on the three most common surgical approaches used for proximal interphalangeal joint arthroplasty: dorsal, volar, and lateral. Advantages and disadvantages of each are highlighted, and the outcomes are discussed. Cite this article: Bone Joint J 2022;104-B(12):1329–1333.
December 2022 Pulmonary Case of the Month: New Therapy for Mediastinal Disease
Authors:   Mayo Clinic Arizona, Phoenix, AZ USA, Wesselius Lewis 
Published: December 2022

No abstract available. Article truncated after the first page. History of Present Illness A 43-year-old woman complained of persistent cough over 1 year with mild increasing dyspnea on exertion. She denied fever, sweats or weight loss. She had noted fatigue and dry cough, as well as shortness of breath, particularly when supine. Past Medical History (PMH), Social History (SH), Family History (FH) •	An outside bronchoscopy done in 2019 with washings and biopsy showing only some non-specific inflammation •	Life-long nonsmoker •	Not on any chronic medications •	Had only lived in Arizona, although has travelled in other states •	There is no significant family history Physical Examination •	Prominent vascularity on anterior chest What should be done at this time? 1.	Chest X-ray 2.	Obtain old x-rays 3.	Pulmonary function testing 4.	Serology for coccidioidomycosis 5.	All of the above …
Student Confidence in Providing Healthcare to Adults With Intellectual Disability: Implications for Health Profession Curricula
Authors: Golub-Victor Ann C. , Peterson Brianna , Calderón Jessica , Lopes Alexandre Dias , Fitzpatrick Diane F. 
Published: December 2022

Abstract
Self-perceived confidence of health professions students at one university in caring for adults with intellectual disability (ID) was examined via an electronic survey using the Therapy Confidence Scale - Intellectual Disabilities (TCS-ID). A stepwise multiple regression of data collected from 232 completed surveys revealed that prior training and prior experience were predictors of TCS-ID total score. Adults with ID experience healthcare disparities due, in part, to poor provider communication and a lack of confidence. Results from this novel study suggest that opportunities for experiential learning and training with people with ID are important considerations for health professions curricula. Further research is needed for generalizability of results.
Clock genes regulate mating activity rhythms in the vector mosquitoes, Aedes albopictus and Culex quinquefasciatus
Authors: Liu Shuang , Zhou Jiayong , Kong Ling , Cai Yiquan , Liu Hongkai , Xie Zhensheng , Xiao Xiaolin , James Anthony A. , Chen Xiao-Guang 
Published: December 2022

Background
Endogenous circadian rhythms result from genetically-encoded molecular clocks, whose components and downstream output factors cooperate to generate cyclic changes in activity. Mating is an important activity of mosquitoes, however, the key aspects of mating rhythm patterns and their regulatory mechanisms in two vector mosquito species, Aedes albopictus and Culex quinquefasciatus, remain unclear.

Methodology/Principal findings
We determined and compared the diel mating activity rhythms of these two mosquito species and discovered that Ae. albopictus had mating peaks in the light/dark transition periods (ZT0-3 and ZT9-12), while Cx. quinquefasciatus only had a mating peak at ZT12-15. Knockouts of the clock (clk) orthologous genes (Aalclk and Cxqclk) resulted in phase delay or phase reversal of the mating peaks in Ae. albopictus and Cx. quinquefasciatus, respectively. In addition, the temporal expression pattern of the desaturase orthologous genes, desat1, in both mosquito species was also different in respective wild-type strains and showed phase changes similar to the mating rhythms in clk mutant strains. Inhibition of desat1 expression resulted in decreased mating activity in male mosquitoes of both species but not females. In addition, desat1 regulated cuticular hydrocarbons’ synthesis in both species. Silencing desat1 in male Ae. albopictus resulted in decreases of nonadecane and tricosane, which promoted mating, with concomitant increases of heptacosane, which inhibited mating. Silencing desat1 in male Cx. quinquefasciatus also resulted in decreases of tricosane, which promoted mating.

Conclusions/Significance
These results suggest that Aalclk and Cxqclk have significant roles in the mating activity rhythms in both Ae. albopictus and Cx. quinquefasciatus by regulating the temporal expression of the desat1 gene under LD cycles, which affects sex pheromone synthesis and mating. This work provides insights into the molecular regulatory mechanism of distinct mating rhythm of Ae. albopictus and Cx. quinquefasciatus and may provide a basis for the control of these two important vector mosquitoes.
An investigation of the impact of human capital and supply chain competitive drivers on firm performance in a developing country
Authors: Santa Ricardo , Ferrer Mario , Tegethoff Thomas , Scavarda Annibal 
Published: December 2022

Purpose
This paper aims to determine the effect that human capital and key competitive drivers such as quality, agility, and cost have on firm performance, whether this effect is related to the firm’s outsourcing strategy, and whether the firm size is relevant in explaining such relationships.

Design
This study uses structural equation modeling to test the hypothesized relationships for small to medium enterprises (SMEs) and large organizations using a custom survey based on a review of the literature and completed by 404 firms in the Valle del Cauca agro-industrial region in Colombia.

Findings
Human capital strategies are essential for the effective deployment of operational agility, quality, and cost management strategies, which impact firm performance through effective outsourcing strategies. These relationships, however, do not hold the same across firms of different sizes. Specifically, outsourcing practices are lacking amongst SMEs in the studied region. The study is limited to a specific region, with infrastructure and connectivity limitations that hinder or undermine otherwise potentially valuable third-party logistics strategies.

Practical implications
This paper contributes to the theory and practice in supply chain competitiveness by extending current knowledge of the impact of human capital and key competitive drivers on firm performance, highlighting regional specificities that could hinder firms’ competitiveness, and by presenting a novel, quantitative methodology seldom used for these topics.
Study on exercise muscle fatigue based on sEMG and ECG data fusion and temporal convolutional network
Authors: Mu Dinghong , Li Fenglei , Yu Linxinying , Du Chunlin , Ge Linhua , Sun Tao 
Published: December 2022

Background
Muscle fatigue is a crucial indicator to determine whether training is in place and to protect trainers.

Purpose
To make full use of morphological information of surface EMG and ECG signals in the time domain, a new idea and method for the fatigue assessment of exercise muscles based on data fusion is proposed in this paper.

Methods
sEMG and ECG time series with the same length were obtained by signal preprocessing and sequence normalization, feature extraction of sequence tenses was realized by a deep learning network based on sequential convolution and signal fusion model of muscle fatigue evaluation was established by D-S evidence theory.

Experiment
Thirty volunteers were recruited and divided into three groups. ECG signals and sEMG signals at the biceps brachii of the right upper limb were monitored in a 20-minute exercise cycle.

Results
The prediction result of TCN based on time domain signal is better than the commonly used KNN and SVM recognition algorithm, and the recognition accuracy of relaxed, excessive and fatigue by D-S fusion was 89%, 86%, 88.5%. The accuracy was 0.9055, 0.9494 and 0.9269, respectively. The recall rates of the three conditions were 0.9303, 0.9570 and 0.9435. The F-score of the three conditions was 0.8911, 0.8764 and 0.8837, respectively.

Conclusion
Based on time series and time series convolutional network, sEMG and ECG fusion of motor muscle recognition method can better distinguish different state information and has certain practical value in the fields of muscle evaluation, clinical diagnosis, wearable devices and so on.
Patterns of antiemetic medication use during pregnancy: A multi-country retrospective cohort study
Authors: Fisher Anat , Paterson J. Michael , Winquist Brandace , Wu Fangyun , Reynier Pauline , Suissa Samy , Dahl Matthew , Ma Zhihai , Lu Xinya , Zhang Jianguo , Raymond Colette B. , Filion Kristian B. , Platt Robert W. , Moriello Carolina , Dormuth Colin R. ,   for the Canadian Network for Observational Drug Effect Studies (CNODES) Investigators
Published: December 2022

Objective
To compare patterns in use of different antiemetics during pregnancy in Canada, the United Kingdom, and the United States, between 2002 and 2014.

Methods
We constructed population-based cohorts of pregnant women using administrative healthcare data from five Canadian provinces (Alberta, British Columbia, Manitoba, Ontario, and Saskatchewan), the Clinical Practice Research Datalink from the United Kingdom, and the IBM MarketScan Research Databases from the United States. We included pregnancies ending in live births, stillbirth, spontaneous abortion, or induced abortion. We determined maternal use of antiemetics from pharmacy claims in Canada and the United States and from prescriptions in the United Kingdom.

Results
The most common outcome of 3 848 734 included pregnancies (started 2002–2014) was live birth (66.7% of all pregnancies) followed by spontaneous abortion (20.2%). Use of antiemetics during pregnancy increased over time in all three countries. Canada had the highest prevalence of use of prescription antiemetics during pregnancy (17.7% of pregnancies overall, 13.2% of pregnancies in 2002, and 18.9% in 2014), followed by the United States (14.0% overall, 8.9% in 2007, and 18.1% in 2014), and the United Kingdom (5.0% overall, 4.2% in 2002, and 6.5% in 2014). Besides use of antiemetic drugs being considerably lower in the United Kingdom, the increase in its use over time was more modest. The most commonly used antiemetic was combination doxylamine/pyridoxine in Canada (95.2% of pregnancies treated with antiemetics), ondansetron in the United States (72.2%), and prochlorperazine in the United Kingdom (63.5%).

Conclusions
In this large cohort study, we observed an overall increase in antiemetic use during pregnancy, and patterns of use varied across jurisdictions. Continued monitoring of antiemetic use and further research are warranted to better understand the reasons for differences in use of these medications and to assess their benefit-risk profile in this population.