bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimating the risk of completion total thyroidectomy using real-world data to guide initial surgical decision-making for patients with clinical low-risk papillary thyroid carcinoma
Authors: Liu Wen , Zhan Xiangxiang , Dong Zhizhong , Su Yanjun , Zhang Jianming , Qian Jun , Ma Yunhai , Diao Chang , Cheng Ruochuan 
Published: November 2022

Abstract
Background
Continuing controversy exists in different guidelines’ recommendations regarding whether total thyroidectomy (TT) or lobectomy is the optimal surgery for patients with low-risk papillary thyroid carcinoma (PTC). Diverse perceptions of the risk of completion TT after lobectomy are the main debate between guidelines and institutions.

Methods
Patients who underwent thyroidectomy and prophylactic central lymph node dissection for ≤ 4 cm PTC (January 2007 to December 2020) by high-volume surgeons were included. Patients with preoperatively known high-risk characteristics or suspicious bilateral multifocality were excluded. The pathological findings were defined as the risk stratifications of completion TT from low to high to evaluate which initial surgical procedure could allow more patients to meet the criteria of optimal surgical extent.

Results
Of 4965 consecutive patients met lobectomy criteria as the initial operation. Aggressive histological subtypes were found in 2.5% of patients, T3b disease in 1.1%, T4 disease in 3.1%, LNs involved ≤ 5 in 29.5%, LNs involved > 5 in 3.1%, and incidental bilateral multifocality in 7.9%. According to our defined risk stratification system, TT and lobectomy would be considered the optimal initial procedure in 12.0% and 67.2% PTC patients with a tumor ≤ 1 cm and 28.7% and 36.6% in the 1–4 cm groups in our real-world cohort, respectively.

Conclusion
Lobectomy alone, as an initial procedure, could allow more low-risk PTC patients with a tumor either ≤ 1 cm or 1–4 cm to achieve the optimal surgical extent. Moreover, surgeons should balance the high-risk characteristics and complication risks during surgery to re-evaluate surgical decision-making.
Comparison of body mass index, anti-müllerian hormone and insulin resistance parameters among different phenotypes of polycystic ovary syndrome
Authors: Gürsu Türkan , Eraslan Alper , Angun Berk 
Published: November 2022

AbstractBackgroundDiagnosis of polycystic ovary syndrome (PCOS) depends on 2003 Rotterdam Criteria. According to these criteria there are four possible combinations resulting in various phenotypes. We aimed (i)to confirm that the levels of body mass index (BMI), anti-müllerian hormone (AMH) levels and insulin resistance (IR) are higher in PCOS patients and higher in phenotype-A among PCOS patients, and (ii)to determine cut-off values for the diagnosis of PCOS and phenotype-A.Materials and methodsThis study was conducted in an IVF Center, between November 2019 and January 2021. Data of infertile women participating in the study was evaluated retrospectively. Parameters such as menstruation pattern, clinical hyperandrogenism, age, BMI, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, thyroid stimulating hormone (TSH), prolactin, AMH, dehydroepiandrosterone sulphate (DHEA-S), fasting blood glucose, fasting insulin levels, antral follicle counts (AFC) and ovarian volumes were recorded for each patient. Women were grouped as PCOS and non-PCOS, and PCOS group was further divided into 4 sub-groups according to their phenotypes. Data of infertile patients with PCOS patients were compared with infertile non-PCOS patients and PCOS phenotypes were compared among each other.ResultsData of 244 infertile patients was included in the study. BMI, AMH, AFC, and HOMA-IR were statistically higher in PCOS patients, compared to non-PCOS patients. We found the AMH level of >3.105 ​ng/ml to be having 90.8% sensitivity and 90% specificity to diagnose a patient as PCOS. Among different phenotypes, also BMI, AMH, and insulin resistance index (HOMA-IR) levels were significantly higher in infertile PCOS phenotype-A when compared to other three phenotypes (p:0.003, p:0.000, and p:0.000, respectively). The AMH cut-off value to estimate phenotype-A was found as 6.095 ​ng/ml with 69.2% sensitivity and 86.7% specificity. We did not found threshold levels of BMI and HOMA-IR with high sensitivity to identify phenotype-A.ConclusionProperly diagnosing PCOS and determining the phenotype are crucial due to the long-term health conditions. Therefore, we suggest that serum AMH level could be included in PCOS diagnosis criteria, and the value of 3.105 ​ng/ml would have a 90.8% sensitivity and 90% specificity. Also, to identify phenotype-A, AMH level could be used. Therefore, we speculate that AMH may serve to identify PCOS and PCOS phenotype-A in places where ultrasound imaging is not straightforward to perform or not easily accessible.
Two times two temperaments of legal scholarship and the question of commodification
Authors: Somek Alexander 
Published: November 2022

AbstractThe article offers a brief account of the continental European (viz., German) and the US American approach to legal education and scholarship. It then explores in which respect legal academics active in these cultures are vulnerable to the lure of commodification, that is, incentives to produce legal expertise for clients. After concluding that these incentives may well be stronger in countries where legal academics consider themselves badly paid and where scholarly traditions are weak, the article explores how commodification can adversely affect the culture of ‘legal science’ as a whole and even work to the detriment of clients.
Defending Ukraine with EU weapons: arms control law in times of crisis
Authors: Hamilton Tomas 
Published: November 2022

AbstractThe wish from 24 February 2022 onwards to help Ukraine defend against Russian aggression has led to the provision of unprecedented lethal European Union (EU) military assistance. As the ‘taboo’ of supplying lethal assistance into non-EU conflicts is swept aside, what is the role of international arms control law? The legal requirements of the EU Common Position on arms exports and the Arms Trade Treaty compel EU Member States to assess various short- and long-term risks associated with arms exports. But it is unclear how arms control norms are being taken into account by the EU Council in its rapidly evolving role as a peacemaker.The standards that are being used to shape EU decision-making on Ukraine matter both for their precedent-setting as reflecting the trajectory of EU normative power, as well as on the long-term blowbacks of proliferation on illicit arms trafficking. While from the EU Council, there has been limited public articulation of these risks, greater consideration thereof would serve as a reminder of the reality of post-conflict arms proliferation, ie. illicit arms trafficking of weapons leached from the conflict, and their subsequent misuse by undesirable actors. Geostrategic precedent is being set, with implications that extend far beyond Ukraine, including to other conflicts where the EU is already intervening. The EU’s delivering of massive lethal military assistance alters also the reflexive perception of its institutions.
The Italian Constitutional Court, the plurality of legal orders and supranational fundamental rights: a discussion in terms of interlegality
Authors: Cozzi Alessia-Ottavia 
Published: November 2022

AbstractThis work aims to investigate the stance of the Italian Constitutional Court (ItCC) on ECHR and CFREU and their respective Courts, ECtHR and CJEU. The aim is to verify if the attitude of the ItCC could be described in terms of openness or closedness, understanding openness as an effort to practise loyal cooperation through procedural means and, substantively, as greater attention for the norms of supranational orders, and closedness as the setting aside of all forms of procedural ties with the supranational Courts and the voluntary dissociation from their outcome, with the purpose of prioritising domestic constitutional provisions. To conduct the analysis, the article refers to the theory of interlegality, questioning whether ItCC, operating ‘on the borders between several normative orders’, has a broader accountability to these different orders. The first part of the paper is devoted to some elements drawn from the case law indicating openness, such as the language use by the ItCC, the procedures, the legal reasoning, and the effects of judgements. Attention is given to the contextual reference to the recognition norms of both the Italian Constitution and European Union (EU) Treaties and to the increasing use of preliminary rulings to the CJEU. The second part of the paper discusses a substantive criterion created by the ItCC, the ‘greatest extension of guarantees’, demonstrating that it does not refer to the level of protection of individual rights, but to the balance of the entire constitutional system. Our conclusion is that the ItCC trends concerning supranational rights express a deferent and operational, but vigilant cooperation, retaining a margin to ensure the vitality of the domestic Constitution.
Elements of prime order in Tate–Shafarevich groups of abelian varieties over
Authors: Shnidman Ari , Weiss Ariel 
Published: November 2022

Abstract
For each prime p, we show that there exist geometrically simple abelian varieties A over

${\mathbb Q}$

with

. Specifically, for any prime

$N\equiv 1 \ \pmod p$

, let

$A_f$

be an optimal quotient of

$J_0(N)$

with a rational point P of order p, and let

$B = A_f/\langle P \rangle $

. Then the number of positive integers

$d \leq X$

with

is

$ \gg X/\log X$

, where

$\widehat B_d$

is the dual of the dth quadratic twist of B. We prove this more generally for abelian varieties of

$\operatorname {\mathrm {GL}}_2$

-type with a p-isogeny satisfying a mild technical condition. In the special case of elliptic curves, we give stronger results, including many examples where

for an explicit positive proportion of integers d.
The effects of cannabidiol on behavioural and oxidative stress parameters induced by prolonged haloperidol administration
Authors: Kajero Jaiyeola Abiola , Seedat Soraya , Ohaeri Jude U. , Akindele Abidemi , Aina Oluwagbemiga 
Published: November 2022

AbstractObjectives:We investigated the influence of oral cannabidiol (CBD) on vacuous chewing movements (VCM) and oxidative stress parameters induced by short- and long-term administration of haloperidol in a rat model of tardive dyskinesia (TD).Methods:Haloperidol was administered either sub-chronically via the intraperitoneal (IP) route or chronically via the intramuscular (IM) route to six experimental groups only or in combination with CBD. VCM and oxidative stress parameters were assessed at different time points after the last dose of medication.Results:Oral CBD (5 mg/kg) attenuated the VCM produced by sub-chronic administration of haloperidol (5 mg/kg) but had minimal effects on the VCM produced by chronic administration of haloperidol (50 mg/kg). In both sub-chronic and chronic haloperidol groups, there were significant changes in brain antioxidant parameters compared with CBD only and the control groups. The sub-chronic haloperidol-only group had lower glutathione activity compared with sub-chronic haloperidol before CBD and the control groups; also, superoxide dismutase, catalase, and 2,2-diphenyl-1-picrylhydrazyl activities were increased in the sub-chronic (IP) haloperidol only group compared with the CBD only and control groups. Nitric oxide activity was increased in sub-chronic haloperidol-only group compared to the other groups; however, the chronic haloperidol group had increased malondialdehyde activity compared to the other groups.Conclusions:Our findings indicate that CBD ameliorated VCM in the sub-chronic haloperidol group before CBD, but marginally in the chronic haloperidol group before CBD. There was increased antioxidant activity in the sub-chronic group compared to the chronic group.
Predicting protein content of silage maize using remotely sensed multispectral imagery and proximal leaf sensing
Authors: Bagheri Nikrooz , Rahimi Jahangirlou Maryam , Jaberi Aghdam Mehryar 
Published: November 2022

Abstract
Timely estimation of silage maize protein provides an effective decision to adapt optimized strategies for nitrogen fertilizer management and also harvesting time for farmers. So, this research aimed to investigate whether using vegetative indices (VIs) derived from UAV remotely sensed multispectral (with 520–900 nm wavelengths) imagery and also Soil Plant Analysis Development (SPAD) greenness index can be used to detect the leaf protein concentration (LPC) of silage maize, as a function of various nitrogen rates (0, 50, 100, and 150% of recommended dosage). Results of principal component analysis (PCA) suggested that LPC was highly correlated with leaf greenness index in all developmental stages. In addition, LPC was highly correlated with most of the VIs investigated. A PCA clustering showed the meaningful pattern of N rates. Higher LPC values, VIs, and greenness index were more concentrated in the higher nitrogen (N100% and N150%) sectors. Nitrogen Reflectance Index (NRI) was identified as the most important VIs to monitor and predict LPC in the silage maize field, showing a strong polynomial relationship with LPC in both eight-leaf collar (V8) (R2 = 0.81, p ≤ 0.01) and tasseling (VT) (R2 = 0.98, p ≤ 0.001) stages. In addition, among VIs, the Normalized Difference Vegetation Index (NDVI) demonstrated a significant linear regression relationship with LPC (R2 = 0.80, p ≤ 0.01) in the VT. Findings suggested the high potential of VIs extracted by UAV-taken multispectral imagery and also SPAD proximal sensing to help farmers rapidly diagnose LPC in silage maize, in line with the objectives of precision farming.
Female sterilisation in India: Examining the role of women’s own decision making and information given to client
Authors: Jana Arjun , Shekhar Chander 
Published: November 2022

AbstractIndia has a very high prevalence of female sterilisation compared to other countries in the world, with a prevailing situation of very low level of information about contraceptive options given to women. It is well established in demographic research that, there exists a strong association between knowledge of contraceptive methods and type of contraception chosen. Present study uses data from 3 consecutive rounds of National Family Health Survey (3, 4 & 5). The sample contains currently married women who started using the current method 5 years prior to each round of survey. Multilevel Logistic Regression and Fairlie Decomposition Model are used to analyse the effect of information given to respondents and decision-making power regarding contraceptive methods on choice of female sterilisation. Women, who are informed about available methods, have lower chance (45.8%, 37.5% & 40% for NFHS 3, 4 & 5 respectively) to opt for sterilisation after controlling all other factors. If woman is the sole decision maker for contraceptive choice, the chance of sterilisation reduces than cases where decision is taken only by husband or jointly. Information about other methods also contributes towards reducing the chance of female sterilisation over the time. Information about contraceptive methods is found to be a major factor in controlling choice of temporary or permanent method. Thus, major focus for the policy makers should be to make information regarding contraceptives more accessible for women.
Freestyling in war and peace: rap and transitional justice in Colombia
Authors: Quishpe Rafael , Escobar Samuel Augusto , Soto Juan Francisco 
Published: November 2022

AbstractRap, as with other musical genres, can contain narratives about Colombia's armed conflict. Members of armed groups, such as the Fuerzas Armadas Revolucionarias de Colombia – Ejército del Pueblo (‘Revolutionary Armed Forces of Colombia – People's Army’; FARC-EP), and civilians have used rap as a means of expressing war-related issues and their causes and consequences. Following the signing of the peace agreement with the FARC-EP in 2016, Colombia's new transitional justice system mainly has focused on a restorative rationale rather than a retributive one. Transitional justice, as a set of mechanisms and processes designed to overcome a violent past, demands peace-building narratives that protect the memory of past horrors while setting the stage for reconciliation. This article analyses the interplay of transitional justice and rap from the personal experiences, perspectives and lyrics of two former combatants and two groups from civil society that rap based in Bogotá, other cities and rural municipalities. These cases provide insight into how rap can relate to transitional justice, sometimes acting as a supportive tool for its goals and sometimes by providing a counter-narrative.
Existential Suffering as a Legitimization of Euthanasia
Authors: Doomen Jasper 
Published: November 2022

AbstractSeveral countries have legalized euthanasia on the basis of medically diagnosable suffering over the last decennial; the criteria to which they adhere differ. The topic of this article is euthanasia on the basis of existential suffering. This article presents a recent proposal to legalize euthanasia for people who experience such suffering and then discusses the issue of what the value of life may be, and whether the standard that life is normally something positive should be accepted. This provides the foundation to answer the question of whether euthanasia on the basis of existential suffering should be allowed.
Internal reference genes with the potential for normalizing quantitative PCR results for oral fluid specimens
Authors: Cheng Ting-Yu , Zimmerman Jeffrey J. , Giménez-Lirola Luis G. 
Published: November 2022

AbstractIn basic research, testing of oral fluid specimens by real-time quantitative polymerase chain reaction (qPCR) has been used to evaluate changes in gene expression levels following experimental treatments. In diagnostic medicine, qPCR has been used to detect DNA/RNA transcripts indicative of bacterial or viral infections. Normalization of qPCR using endogenous and exogenous reference genes is a well-established strategy for ensuring result comparability by controlling sample-to-sample variation introduced during sampling, storage, and qPCR testing. In this review, the majority of recent publications in human (n= 136) and veterinary (n= 179) medicine did not describe the use of internal reference genes in qPCRs for oral fluid specimens (52.9% animal studies; 57.0% human studies). However, the use of endogenous reference genes has not been fully explored or validated for oral fluid specimens. The lack of valid internal reference genes inherent to the oral fluid matrix will continue to hamper the reliability, reproducibility, and generalizability of oral fluid qPCR assays until this issue is addressed.
Seismic Constraints on Crustal and Uppermost Mantle Structure Beneath the Hawaiian Swell: Implications for Plume‐Lithosphere Interactions
Authors: Le Ba Manh , Yang Ting , Morgan Jason P. 
Published: November 2022

AbstractWe infer the lithospheric structure beneath the Hawaiian Swell based on a joint inversion of ambient noise and teleseismic Rayleigh waves collected during the PLUME experiment. These combined datasets let us use Rayleigh waves with a period range of 8–50 s that provides imaging resolution for the shallow lithosphere and constrains interactions between the upwelling plume and migrating plate. We find an elongated low‐velocity anomaly beneath the lithosphere along the island chain that connects to the plume conduit, consistent with the melting region associated with a restite hotspot swell root that has mechanically eroded the base of its overlying lithosphere. It could also be consistent with a plume refracted by the overriding plate motion if the plume could manage to deeply erode the lithospheric base, as only a more viscous restite root is seen to do in thermomechanical experiments. There is also a low‐velocity body beneath the North Arch that coincides with the location of recent off‐chain volcanic fields discovered there. Its location relative to the Molokai Fracture Zone (MFZ) supports the concept that swell‐root material has preferentially spread beneath the younger side of the MFZ. We also find a clear low‐velocity anomaly associated with the uppermost ∼50 km of the fracture zone lithosphere. The relatively well‐resolved shallow lithospheric structure determined here allows us to estimate the volumes of underplating and the total flux of the rising plume material that is added beneath the Hawaiian lithosphere, which we constrain to be in the range of 0.5–0.6 km3/yr.
Coupling Crustal‐Scale Rift Architecture With Passive Margin Salt Tectonics: A Geodynamic Modeling Approach
Authors: Pichel Leonardo M. , Huismans Ritske S. , Gawthorpe Robert , Faleide Jan Inge , Theunissen Thomas 
Published: November 2022

AbstractContinental rifted margins are often associated with widespread, thick evaporite (i.e., salt) deposits and pronounced salt tectonics. The majority of salt basins formed during the latest stages of rifting, prior to continental breakup. We use 2D thermo‐mechanical finite element modeling of lithospheric extension to investigate the interplay between rifted margin architecture, late syn‐rift salt deposition, and post‐rift salt tectonics. We focus on four different types of continental margins: (a) narrow, (b) intermediate, (c) wide, and (d) ultra‐wide margins. We evaluate the: (a) interplay between laterally variable syn‐rift extension, salt deposition and salt tectonics, (b) influence of syn‐rift basin architecture on post‐rift salt flow, (c) spatial and temporal distribution of salt‐related structural domains, and (d) contrasting styles of salt tectonics for different margin types. Narrow and intermediate margins form partially isolated salt basins associated with prominent base‐salt relief, limited translation but significant diapirism, and minibasin development. Wide and ultra‐wide margins form wide salt basins with subtle base‐salt relief that results in significant seaward salt expulsion and overburden translation. These wide margins demonstrate significant updip extension with the development of post‐rift normal faults and rollovers, mid‐margin translation associated with complex diapirism and downdip diapir shortening. All margins contain a distal salt nappe that varies in width and complexity. We also test the effect of different salt viscosities, relative post‐salt progradation rates, and pre‐salt sediment thicknesses. The results are comparable to several examples of salt‐bearing rifted margins and improve our understanding of their dynamics and on the controls on their salt tectonics variability.