bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-phase strategy to mitigate first cycle effect in diffuse large B cell lymphoma
Authors: Rudresha A. H. , Hassan Syed Adil , Sreevalli A. , Lokanatha D. , Babu M. C. Suresh , Lokesh K. N. , Rajeev L. K. , Saldanha Smitha , Thottian Antony G. F. , Sharma Kanika , Jacob Linu Abraham 
Published: May 2022

Abstract
Context
Treatment-related toxicities in DLBCL (diffuse large B cell lymphoma) patients are higher in the initial phase of treatment (first cycle effect). Implementation of pre-phase treatment before definitive chemotherapy had been shown to alleviate some of these side-effects in a non-randomized study conducted earlier in our institute (Lakshmaiah et. al., Eur J Haematol 100:644-8, 2018).

Aims
This study was aimed at validating the role of pre-phase treatment in newly diagnosed DLBCL patients.

Settings and design
All newly diagnosed patients with DLBCL above the age of 18 years were evaluated for eligibility and prospectively enrolled. A single-arm prospective study was conducted at the Department of Medical Oncology, in our institute from July 2015 to December 2019.

Methods and material
Patients received vincristine and prednisolone as pre-phase treatment for 7 days after which definitive chemotherapy was instituted on day 1. They were followed up for 30 days post-first cycle chemotherapy.

Statistical analysis used
Paired Student’s t tests and Wilcoxon signed-ranks test were used for comparison of various clinical variables as appropriate. P value of less than 0.05 was considered significant.

Results
Among the 180 patients who were included in study, performance status improvement was noted in significant number of patients (p < 0.001). 38.4% achieved an ECOG (Eastern Cooperative Oncology Group) performance status of 0 post-pre-phase therapy. Febrile neutropenia was observed in 12.8% in the present cohort as compared to the historical non-pre-phase cohort (34%).

Conclusions
Pre-phase therapy significantly improves the performance status and diminishes neutropenia rates in DLBCL patients.
Effects of Testosterone on Mixed-Muscle Protein Synthesis and Proteome Dynamics During Energy Deficit
Authors: Howard Emily E , Shankaran Mahalakshmi , Evans Willian J , Berryman Claire E , Margolis Lee M , Lieberman Harris R , Karl J Philip , Young Andrew J , Montano Monty A , Matthews Marcy D , Bizieff Alec , Nyangao Edna , Mohammed Hussein , Harris Melissa N , Hellerstein Marc K , Rood Jennifer C , Pasiakos Stefan M 
Published: May 2022

Abstract

Context
Effects of testosterone on integrated muscle protein metabolism and muscle mass during energy deficit are undetermined.

Objective
The objective was to determine the effects of testosterone on mixed-muscle protein synthesis (MPS), proteome-wide fractional synthesis rates (FSR), and skeletal muscle mass during energy deficit.

Design
This was a randomized, double-blind, placebo-controlled trial.

Setting
The study was conducted at Pennington Biomedical Research Center.

Participants
Fifty healthy men.

Intervention
The study consisted of 14 days of weight maintenance, followed by a 28-day 55% energy deficit with 200 mg testosterone enanthate (TEST, n = 24) or placebo (PLA, n = 26) weekly, and up to 42 days of ad libitum recovery feeding.

Main Outcome Measures
Mixed-MPS and proteome-wide FSR before (Pre), during (Mid), and after (Post) the energy deficit were determined using heavy water (days 1-42) and muscle biopsies. Muscle mass was determined using the D3-creatine dilution method.

Results
Mixed-MPS was lower than Pre at Mid and Post (P &lt; 0.0005), with no difference between TEST and PLA. The proportion of individual proteins with numerically higher FSR in TEST than PLA was significant by 2-tailed binomial test at Post (52/67; P &lt; 0.05), but not Mid (32/67; P &gt; 0.05). Muscle mass was unchanged during energy deficit but was greater in TEST than PLA during recovery (P &lt; 0.05).

Conclusions
The high proportion of individual proteins with greater FSR in TEST than PLA at Post suggests exogenous testosterone exerted a delayed but broad stimulatory effect on synthesis rates across the muscle proteome during energy deficit, resulting in muscle mass accretion during subsequent recovery.
Access Site Complications and Management of the Transradial Approach for Neurointerventions
Authors: Weinberg Joshua H. , Sweid Ahmad , Asada Ashlee , Schaefer Joseph , Ruiz Ramon , Kang KiChang , Gooch Michael Reid , Herial Nabeel A. , Tjoumakaris Stavropoula , Zarzour Hekmat , Rosenwasser Robert H. , Jabbour Pascal 
Published: May 2022

BACKGROUND:
The transradial approach has increasingly been used for neurointerventions because of the improved safety profile compared with transfemoral. However, it is important to be aware of potential complications such as radial artery (RA) spasm, RA occlusion, pseudoaneurysm, extravasation, arteriovenous fistula, and wrist hematoma as well as their management.

OBJECTIVE:
To present our institution's experience with the prevention and management of local access site complications associated with the transradial approach for neuroendovascular interventions.

METHODS:
We conducted a retrospective analysis of a prospectively maintained database and identified 1524 consecutive neuroendovascular procedures performed using transradial access from April 2018 to February 2021.

RESULTS:
Among 1524 procedures, local transradial complications occurred in 1.7%. Major complications occurred at a rate of 1.2% including RA extravasation (0.3%), delayed RA occlusion (0.6%), pseudoaneurysm (0.1%), compartment syndrome (0.1%), infection (0.1%), and avulsion of the RA in 0.1% (1 of 1524) with no serious clinical consequence. Although RA occlusion is included in major complications, all cases were asymptomatic and did not require any intervention. Minor complications occurred at a rate of 0.5% including severe RA spasm (0.3%) and hematoma (0.3%). No patient in the cohort died or suffered from permanent disability from a complication related to the transradial approach.

CONCLUSION:
Transradial access for neurointervention has a low rate of local complications, particularly when taking appropriate prevention measures. Appropriate management of complications can prevent procedural failure and has low morbidity rates demonstrating the overall safety profile of transradial access even when complications occur.
Molecular determinants of αVβ5 localization in flat clathrin lattices – role of αVβ5 in cell adhesion and proliferation
Authors: Zuidema Alba , Wang Wei , Kreft Maaike , Bleijerveld Onno B. , Hoekman Liesbeth , Aretz Jonas , Böttcher Ralph T. , Fässler Reinhard , Sonnenberg Arnoud 
Published: May 2022

ABSTRACT
The vitronectin receptor integrin αVβ5 can reside in two distinct adhesion structures – focal adhesions (FAs) and flat clathrin lattices (FCLs). Here, we investigate the mechanism that regulates the subcellular distribution of β5 in keratinocytes and show that β5 has approximately 7- and 5-fold higher affinity for the clathrin adaptors ARH (also known as LDLRAP1) and Numb, respectively, than for the talin 1 (TLN1); all proteins that bind to the membrane-proximal NPxY motif of the β5 cytoplasmic domain. Using mass spectrometry, we identified β5 interactors, including the Rho GEFs p115Rho-GEF and GEF-H1 (also known as ARHGEF1 and ARHGEF2, respectively), and the serine protein kinase MARK2, depletion of which diminishes the clustering of β5 in FCLs. Replacement of two serine residues (S759 and S762) in the β5 cytoplasmic domain with phospho-mimetic glutamate residues causes a shift in the localization of β5 from FAs into FCLs without affecting the interactions with MARK2, p115Rho-GEF or GEF-H1. Instead, we demonstrate that changes in the actomyosin-based cellular contractility by ectopic expression of activated Rho or disruption of microtubules regulates β5 localization. Finally, we present evidence that β5 in either FAs or FCLs functions to promote adhesion to vitronectin, cell spreading, and proliferation.
Daylight-Driven Rechargeable TiO2 Nanocatalysts Suppress Wheat Blast Caused by Magnaporthe oryzae Triticum
Authors: Mahmud Nur Uddin , Gupta Dipali Rani , Paul Sanjoy Kumar , Chakraborty Moutoshi , Mehebub Md Shabab , Surovy Musrat Zahan , Rabby S M Fajle , Rahat Abdullah Al Mahbub , Roy Paritosh Chandra , Sohrawardy Hossain , Amin Mohammed A , Masud Mostafa Kamal , Ide Yusuke , Yamauchi Yusuke , Hossain Md Shahriar , Islam Tofazzal 
Published: May 2022

Abstract
Wheat blast, caused by the Magnaporthe oryzae Triticum (MoT) pathotype, threatens wheat production in many countries, including Bangladesh. Traditional fungicides are ineffective in combating this pathogen, and no resistant wheat variety is available. This study investigated the mechanism of wheat blast suppression by a nanostructured TiO2 nanocatalyst (NC) that generates reactive oxygen species through a photocatalytic process under daylight settings. In the presence of sunlight, the NCs displayed a high antifungal activity against MoT in vitro (minimum inhibitory concentration - MIC 0.025 mg/ml), as well as suppressed conidial formation and mycelial growth of MoT. Moreover, the fungal biomass was drastically reduced at NC concentrations ≥0.5 mg/ml. In vivo seedling assays showed inhibition of wheat blast when wheat seedlings were artificially inoculated with conidia. Under daylight conditions, NCs at a concentration from 0.1 to 0.5 mg/ml can protect wheat plants from MoT likely by inducing oxidative stress in the pathogen. Field trials of TiO2 NCs prevented more than 90% of disease incidence, with optimum yields, at NC concentrations ≥0.5 mg/ml. These results indicate that daylight-driven rechargeable NCs effectively suppress MoT in vitro and control wheat blast in the field.
Thermodynamic and Kinetic Studies on Copper-Catalyzed Cross-Dehydrogenative Couplings of N-Aryl Glycine Esters with Phenols
Authors: Xu Xiaofei , Zheng Wenrui , Ren Lufei , Jiao Peilei 
Published: May 2022

Abstract
Copper-catalyzed cross-dehydrogenative coupling (CDC) reactions have been esteemed as a straightforward and efficient tool for C–C bonds formation. The single electron transfer (SET) process plays a vital role during the overall catalytic cycle. In the present density functional theory (DFT) study on the oxidation potential (Eox), which could reflect the SET occurring tendency from a thermodynamic respect as well as the substituent effects and structure-activity relationships for four classes of N-based compound substrates including THIQs, N,N-dimethylanilines, 3-benzylindoles, and N-phenylglycine esters derivatives have been fulfilled. Many quantitative structure-activity relationships between Eox and structural parameters, including HOMO energies, the Hammett substituent constant σ+ and so on were found. Furthermore, in the kinetics research section, we have performed four possible pathways of CDC reaction of N-aryl glycine esters with phenols in a CuBr/TBHP catalytic oxidation system. The results support the pathway wherein the formation of an iminium cation-type intermediate is involved would be more favorable. In addition, the solvent and substituent effects of two key steps including H-abstraction and C–C bond formation rate-determining step were explored, which could afford a total understanding of the mechanism regarding the Cu-catalyzed CDC reaction as well as the substrates and solvents screening.
Seasonal variation of mammal roadkill hotspots in the Sierra Madre Occidental, México
Authors: Cervantes-Huerta Rodolfo , Durán-Antonio Jessica 
Published: May 2022

Los puntos críticos del atropellamiento son aquellos sitios agregados espacialmente que no corresponden al azar. Para el caso de mamíferos, los puntos críticos han sido considerados como una de las aproximaciones para la ubicación de las obras de mitigación del atropellamiento, aunque estos sitios pueden ser variables a escalas temporales. El objetivo de este estudio fue identificar los cambios de los puntos críticos del atropellamiento de mamíferos entre dos temporadas en una carretera en la Sierra Madre Occidental en el noreste de México. Para el monitoreo de las especies atropelladas se realizaron 2 recorridos en vehículo por temporada con 15 días de separación entre recorridos. Estos se realizaron en la primavera de 2019 y 2020 y otoño de 2018 y 2019 en la carretera 40D (Durango-Mazatlán). Utilizando herramientas de sistemas de información geográfica, se estimaron los puntos críticos de atropellamiento de mamíferos para la primavera, el otoño y ambas estaciones. Se obtuvieron 217 registros de mamíferos silvestres atropellados en 8 recorridos sobre la carretera. Los puntos críticos de atropellamiento de fauna no coinciden espacialmente entre las estaciones, ni al compararlos con todos los registros. La acumulación espacial del atropellamiento de mamíferos no fue coincidente en el tiempo, lo cual podría relacionarse con los cambios en el movimiento de la fauna y otros factores. Se debe considerar la variación estacional de estos puntos críticos para las obras de mitigación, así como realizar monitoreos sistemáticos de la fauna atropellada.
Urinary incontinence in men: what the practice nurse needs to know
Authors: Yates Ann 
Published: May 2022

Male incontinence is an underestimated condition. Ann Yates explores the role practice nurses can play in identifying, treating and managing the conditionMale urinary incontinence is an underestimated condition, with health professionals unaware of the risk factors and, even when aware, unsure of how to address them. This article will identify current known prevalence figures, identify known risk factors and will then progress to identify how to undertake an assessment of the presenting symptoms, conservative treatment options and, finally, management options.
Evaluating Two Low-Cost GPS Receivers for Accuracy and Eventual Use in Pastured Cattle Research
Authors: Abdulai Gabriel A. , Sama Michael P. , Jackson Joshua J. 
Published: May 2022

HighlightsA stand-alone GPS receiver produced comparably lower location errors than a smartphone GPS.Low-cost GPS receivers are suitable for use in research on large-herd cattle behavioral response to UAVs.Different testing placements can influence the horizontal accuracy of low-cost GPS receivers and smartphones.Abstract. Using animal-borne global positioning system (GPS) collars, cattle behavioral response to anthropogenic disturbances can be accurately quantified at fine scale. However, the use of dedicated commercial GPS collars in large herd studies is cost-prohibitive. Therefore, low-cost GPS receiver alternatives were evaluated in static placements to determine how their accuracy compares to published data for commercial animal-borne GPS collars. The static accuracies of identical low-cost stand-alone GPS receivers and smartphones were evaluated in an open field without obstructions, under trees with and without canopy, and near an electric fence at 5 min and 1 s sample intervals. The mean circular error probable (CEP) value of the stand-alone GPS receiver was =2 m at 5 min and at 1 s in open field placement. The mean CEP value of the stand-alone GPS receiver was =3 m at 5 min and at 1 s when placed near the electric fence. The smartphone produced mean CEP values of =4 m at 5 min and =3 m at 1 s for the fence line and open field placements. Static testing under trees with canopy at the 5 min sample interval produced mean CEP values 100% greater than under trees without canopy at the 1 s sample interval. Low-cost commercial GPS receivers and smartphones with horizontal accuracy of =5 m at high sample resolution may offer accurate means of quantifying the behavioral response of cattle to UAVs in large herd studies. Keywords: Cattle behavior, Global positioning system, Horizontal accuracy, Smartphone GPS, Stand-alone GPS receiver, UAV, Unmanned aerial vehicle.
Who are the women who relinquish infants for adoption? Domestic adoption and contemporary birth motherhood in the United States
Authors: Sisson Gretchen 
Published: May 2022

AbstractIntroductionThe social context of pregnancy decision‐making has changed in recent decades in the United States (US), but little research has examined how these changes manifest in the context of infant adoption.MethodsTo create an updated profile of US birth mothers, this analysis uses demographic data collected and aggregated from six adoption agencies, with information on 8658 private adoptions that occurred between 2011 and 2020.ResultsBased on this sample, birth mothers today are older and more racially and ethnically diverse than counterparts in previous generations; a majority have other had children and a substantial proportion were parenting other children at the time of relinquishment. They report living on low incomes and, when considered with other measures (e.g., employment, health insurance, homelessness), seem to lack the economic resources that would give them meaningful power over the options available to themselves and their children. Most birth mothers contact agencies late in their pregnancies or after delivery, at a point when abortion care is likely inaccessible or unavailable. An important minority of birth mothers will relinquish more than one infant for adoption over the course of their reproductive lives.ConclusionGiven the underlying shift in the demographic profile of women who relinquish infants, it is likely that the underlying circumstances that lead to adoption have also diverged. More research is needed into how women make decisions about adoption; such research carries implications for how best to support women's decision‐making and ensure access to needed services throughout pregnancy and beyond.
Liver vitronectin release into the bloodstream increases due to reduced vagal muscarinic signaling after cerebral stroke in female mice
Authors: Keasey Matthew P. , Lovins Chiharu , Jia Cuihong , Hagg Theo 
Published: May 2022

AbstractVitronectin (VTN) is a glycoprotein enriched in the blood and activates integrin receptors. VTN blood levels increase only in female mice 24 h after an ischemic stroke and exacerbate brain injury through IL‐6‐driven inflammation, but the VTN induction mechanism is unknown. Here, a 30 min middle cerebral artery occlusion (MCAO) in female mice induced VTN protein in the liver (normally the main source) in concert with plasma VTN. Male mice were excluded as VTN is not induced after stroke. MCAO also increased plasma VTN levels after de novo expression of VTN in the liver of VTN−/− female mice, using a hepatocyte‐specific (SERPINA1) promoter. MCAO did not affect SERPINA1 or VTN mRNA in the liver, brain, or several peripheral organs, or platelet VTN, compared to sham mice. Thus, hepatocytes are the source of stroke‐induced increases in plasma VTN, which is independent of transcription. The cholinergic innervation by the parasympathetic vagus nerve is a potential source of brain‐liver signaling after stroke. Right‐sided vagotomy at the cervical level led to increased plasma VTN levels, suggesting that VTN release is inhibited by vagal tone. Co‐culture of hepatocytes with cholinergic neurons or treatment with acetylcholine, but not noradrenaline (sympathetic transmitter), suppressed VTN expression. Hepatocytes have muscarinic receptors and the M1/M3 agonist bethanechol decreased VTN mRNA and protein release in vitro via M1 receptors. Finally, systemic bethanechol treatment blocked stroke‐induced plasma VTN. Thus, VTN translation and release are inhibited by muscarinic signaling from the vagus nerve and presents a novel target for lessening detrimental VTN expression.
Urheberrecht wagen – Dokumentenlieferung aus digitalen Ressourcen
Authors: Brettschneider Peter 
Published: May 2022

Zusammenfassung
Im letzten Jahrzehnt ist die Zahl der Fernleihen und Dokumentenlieferungen dramatisch zurückgegangen. Ein zentraler Faktor dafür ist das Anwachsen der digitalen Bestände, im Hinblick auf die Lieferbegehren regelmäßig abgelehnt werden. Der Beitrag untersucht die Rechtslage beim Kopienversand aus digitalen Medien und argumentiert, dass eine Lieferung in der überwiegenden Zahl der Fälle erlaubt wäre. Abschließend wird ein auf formalen Kriterien basierendes Prüfungsschema für die praktische Umsetzung in der Dokumentenlieferung vorgeschlagen.
Expression of Zeb1 in the differentiation of mouse embryonic stem cell
Authors: Chen Ting , Pan Peng , Wei Wei , Zhang Yanmin , Cui Guanghui , Yu Zhendong , Guo Xin 
Published: May 2022

Abstract
Embryonic stem cells (ESCs) differentiation is a process of replication and refinement, and the directional lineage differentiation of ESCs involves the epithelial-mesenchymal transition (EMT)- mesenchymal-epithelial transition (MET) process. A previous study revealed that Zinc finger E-box-binding homeobox 1 (Zeb1) plays a vital role in EMT, which could repress E-cadherin promoter and induce an EMT in cells. To verify the expression of Zeb1 and its correlation with Lin28a in mouse ESCs differentiation, we performed qRT-PCR and western blots to detect the expression of Lin28a mRNA and protein after Zeb1 knockdown. The expression of Zeb1 decreased over time of mouse ESCs differentiation but significantly increased in mouse embryonal carcinoma cells. After knockdown of Zeb1, Lin28a and Vimentin expression were decreased, while E-cadherin expression increased both in mouse ESCs, EBs, GC1, and P19 cells. We found that Zeb1 promoted the invasive ability of mouse embryonal carcinoma cells. These results revealed that expression of Zeb1 decreased during the differentiation of ESCs, and Lin28a and EMT processes can be regulated by Zeb1, which need to be verified in the future studies.
Visualizing legal translation: a bibliometric study
Authors: Li Jian , Hu Xitao 
Published: May 2022

Abstract
As researches in legal translation advance rapidly, it is critical to keep abreast of emerging trends and critical turns of the collective knowledge development in this field. A bibliometric network using Citespace to examine the original articles obtained from an initial topic search on legal translation can provide a visualized profile for various themes in legal translation, by facilitating the analysis of the status quo, intellectual base, hotspots and emerging trends and providing a systematic review of the evolution of legal translation literature. According to a scientometric analysis of academic publications collected in the Web of Science Core Collection related to legal translation, this study profiles the key topics, the most influential institutions, authors and journals in this area, as well as the distribution of category and the future trend in the field. The scientometric analysis is expected to offer an overall view of legal translation per se as well as to provide implications for studies in relevant fields.
The language of evaluation in a Philippine drug trial: an appraisal framework perspective
Authors: Deuna Ina Francesca G. , Ballesteros-Lintao Rachelle 
Published: May 2022

AbstractIn courtroom discourses, evaluative language serves a pivotal role in assessing witnesses for determining the credibility of the testimonies provided and consequently influencing the outcome of the trial. Adopting the appraisal framework, this paper conducted a case study to examine the attitude resources used by court participants in a Philippine drug trial to determine the presence and use of evaluations in courtroom discourse, particularly across trial stages. Results showed that JUDGMENT is the most prevalent valuation in the study with its sub-system Tenacity scoring the highest frequency, followed by APPRECIATION and its sub-category valuation, while AFFECT was uncommon in the trial. The attitude items were also found to be most prevalent in the direct-examination and cross-examination stages to highlight the following: the knowledge of the witnesses on the incident, their involvement in the incident, and the sources of their information. It also showed the adherence of the judge to the principle of neutrality as the decision focused on the legal norms of the facts of the case. The results also attest that ‘legality’ is a distinct feature of the evaluative language in courtroom discourse.