bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improve Of Gasless Laparoscopic Single-Site Suspension And Use In Surgery For Endometrial Cancer
Authors: Zhao Bing bing , Lu XIN qiu , Xu Li , li Li , Zhang Jieqing 
Published: March 2022

Abstract
Objective: To investigate the improve in Gasless Laparoscopic single-site suspension and use in surgery for endometrial cancer.And to compare the outcome of different surgical style in endometrial cancer.Method: A tissue retractor is added to the routine step of Gasless Laparoscopic single-site(GLESS) to lift the abdominal wall upward. Lateral umbilical ligament was exposed, and 2-0 buckwheat thread was passed through the umbilical ligament and abdominal wall, then lift the umbilical ligament.Measure the changes of space length or height in different dimensions of improved GLESS. Measure the vertical height from the upper edge of the umbilical hole to the abdominal cavity, the length from the lower edge of the umbilical hole to the right Michaelis point, the height from the bottom of the uterus to the peritoneal cavity of the anterior abdominal wall, and the length from the lateral umbilical ligament to the ipsilateral psoas major muscle.To analyze the differences operations of 177 cases of endometrial carcinoma in operation time, hemoglobin change, number of lymph nodes removed, postoperative exhaust time and postoperative complications of open surgery, multi site laparoscopic surgery, single site laparoscopic surgery and gasless Laparoscopic single-site surgery for endometrial cancer.Result: After improvement, the operation space increased significantly. There was no significant difference in the operation time, hemoglobin change, number of lymph nodes removed, postoperative exhaust time and postoperative complications of endometrial cancer.Conclusion: The improvement of GLESS can exposed to a greater surgen space. At the same time, the way of suspending the umbilical ligament through abdominal silk thread can expose the anatomical structure of obturator position to a greater extent.The application of GLESS in the operation of endometrial cancer is safe and feasible.
GC-MS analysis of important bioactive compounds in bulbs and callus of in vitro produced Urginea maritima.
Authors: El-Naggar Hany , Shahata Ashraf M. , Morsi Mennat-allah 
Published: March 2022

Abstract
Medicinal herbs are the main source of bioactive compounds used in the medicine industry. Urginea maritima is an important medicinal and ornamental plant cultivated in the Mediterranean region. This study reports an efficient protocol for in vitro propagation of Urginea and investigates the most important bioactive compounds present in the bulbs and in vitro-produced callus. The least number of days for callus induction and shoot regeneration was achieved in Murashige and Skoog MS basal media supplemented with (1 mg/L 1-naphthaleneacetic acid NAA + 0.1 mg/L 6-benzylaminopurine, BAP) and (1 mg/L NAA + 0.4 mg/L BAP), respectively, while the highest number of shoots and fresh weight were obtained in media supplemented with 1 mg/L NAA + 0.5 mg/L BAP. Gas chromatography–mass spectrometry GC–MS analysis of Urgenia bulbs methanol extract showed the existence of important bioactive compounds such as palmitic acid (C16H32O2), 9-hexadecenoic acid (C16H30O2), phthalic acid 2-ethylhexyl propyl ester (C19H28O4), tetradecanoic acid (C14H28O2), undecanoic acid (C11H22O2), and oleic acid (C18H34O2), in addition to other important compounds such as 13-heptadecyn-1-ol, 9,12- octadecadienoic acid, 1-monolinoleoylglycerol trimethylsilyl ether, 2-methyl-1-hexadecanol and octadecanoic acid. These compounds possess antioxidant, anti-inflammatory, anti-HIV, antifungal, antiasthma, and antimicrobial properties. Callus methanol extracts showed a reduction in the percentages of most phyto-components compared to bulb extract except for oleic acid, 3-(octadecyloxy) propyl ester and 3-hydroxydodecanoic acid; on the other hand, some compounds were detected only in callus extract possessing anticancer and anti-inflammatory effects, such as farnesol (C15H26O), 7-methyl-Z-tetradecen-1-ol acetate (C17H32O2), ethyl iso-allocholate (C26H44O5), 4-trifluoroacetoxypentadecane (C17H31F3O2) and 2-hydroxyhexadecanoic acid (C16H32O3).
Generation of Multipartite Entanglement Between Spin-1 Particles With Bifurcation-based Quantum Annealing
Authors: Matsuzaki Yuichiro , Imoto Takashi , Susa Yuki 
Published: March 2022

Abstract
Quantum annealing is a way to solve a combinational optimization problem where quantum fluctuation is induced by transverse fields. Recently, a bifurcation-based quantum annealing with spin-1 particles was suggested as another mechanism to implement the quantum annealing. In the bifurcation-based quantum annealing, each spin is initially prepared in |0⟩, let this state evolve by a time-dependent Hamiltonian in an adiabatic way, and we find a state spanned by | ± 1⟩ at the end of the evolution. Here, we propose a scheme to generate multipartite entanglement, namely GHZ states, between spin-1 particles by using the bifurcation-based quantum annealing. We gradually decrease the detuning of the spin-1 particles while we adiabatically change the amplitude of the external driving fields. Due to the dipole-dipole interactions between the spin-1 particles, we can prepare the GHZ state after performing this protocol. We discuss possible implementations of our scheme by using nitrogen vacancy centers in diamond.
Prognostic Utility of LncRNAs (LINC00565 and LINC00641) as Molecular Markers in Glioblastoma Multiforme (GBM)
Authors: Amer Rehab G , Arab Lobna Ezz El , Ghany Dalia Abd El , Saad Amr S , Bahie-Eldin Nermean , Swellam Menha 
Published: March 2022

Abstract
Background and aim.
Glioblastoma multiforme (GBM) are primary brain tumor grade IV characterized by fast cell proliferation, high mortality and morbidity and most lethal gliomas. Molecular approaches underlying its pathogenesis and progression with diagnostic and prognostic value have been an area of interest. Long-non coding RNA (lncRNA) aberrantly expressed in GBM have been recently studied. The aim is to investigate the clinical role of lncRNA565 and lncRNA641 in GBM patients.
Patients and methods.
Blood samples were withdrawn from 35 newly diagnosed GBM cases with 15 healthy individuals, then lncRNA565 and lncRNA641 expression were evaluated using real time-PCR.Their diagnostic efficacy was detected using receiver operating characteristic curve. Progression free survival (PFS) and overall survival (OS) were studied using Kaplan-Meier curves.
Results.
LncRNAs expression was increased significantly among GBM as compared to control group. Their expression was correlated with clinico-pathological data and survival pattern for the studied GBM patients. Higher levels of both Lnc RNAs were correlated to worse performance status. Expression of lncRNA565 was increased with large tumor size (≥ 5cm).Survival analysis showed that both investigated lncRNA were increased with worse PFS and OS.
Conclusion.
Expression of lncRNA 565 and lncRNA 641 in a liquid biopsy sample can be used as prognostic biomarker for GBM patients.
Comparison Between Two- and Three-dimensional Methods for Offset Measurements After Total Hip Arthroplasty
Authors: Tone Shine , Hasegawa Masahiro , Naito Yohei , Wakabayashi Hiroki , Sudo Akihiro 
Published: March 2022

Abstract
The aim of this study was to compare acetabular offset, femoral offset, and global offset measurements obtained after total hip arthroplasty (THA) between a two-dimensional (2D) method and a three-dimensional (3D) method. The subjects were 89 patients with unilateral osteoarthritis who underwent primary THA at our institution. Acetabular, femoral, and global offsets were measured by each of the 2D and 3D methods in native and implanted hips. In native hips, mean acetabular, femoral, and global offsets were 32.4 ± 3.3, 32.7 ± 4.5, 65.1 ± 5.7 mm, respectively, by the 2D method, and 32.3 ± 3.1, 38.1 ± 4.0, 70.4 ± 4.9 mm, respectively, by the 3D method. In implanted hips, mean acetabular, femoral, and global offsets were 27.6 ± 4.1, 33.8 ± 7.8, 61.4 ± 8.5 mm, respectively, by the 2D method, and 27.6 ± 3.9, 41.8 ± 6.2, 69.4 ± 7.2 mm, respectively, by the 3D method. There was significant difference in femoral and global offsets between the 2D and 3D methods in both native and implanted hips. Comparison of the 2D and 3D methods for evaluation of acetabular, femoral, and global offsets after THA clarified the usefulness and accuracy of the 3D method.
Choline and Parecoxib Sodium Induced Pain Inhibition in Rats After Chronic Constriction Injury of the Sciatic Nerve
Authors: Zhang Na , Li Yang , Feng Zeguo 
Published: March 2022

Abstract
Purpose
We aimed to examine the pain inhibitory effects of systemic administration of choline and parezoxib sodium in a rat model of neuropathic pain induced by a chronic constriction injury (CCI) of the sciatic nerve, and to determine the changes of high mobility protein-1 (HMGB1) and NF-κBp65 expression in the dorsal root ganglion (DRG) after drug treatment.
Methods
Adult rats were randomly divided into 5 groups (N = 8/group). Sham surgery group received an intraperitoneal (i.p.) injection of saline. CCI rats received saline, choline (cho, 6, 12 and 24 mg/kg), parecoxib sodium (pare, 3, 6, 12mg/kg), or a combination of choline and parecoxib sodium with each drug delivered at a sub-effective dose. Mechanical and heat pain thresholds were measured at 30 min after drug treatment at day 3, 5, 7, 10, and 14 after CCI. In a separate study, rats were also divided into 5 groups (N = 6/group) including sham, CCI + saline, CCI + cho-6 mg/kg, CCI + pare-3mg/kg, and CCI + cho-6mg/kg + pare-3mg/kg group. After repeated drug treatment for 7 days, five rats were randomly selected in each group, and the lumbar DRGs (L4-6) were harvested for Western blot study.
Results
Choline significantly attenuated the mechanical and heat hypersensitivities in CCI rats at 12 and 24 mg/kg doses (P < 0.05), but was not effective at 6 mg/kg dose. Parecoxib sodium exerted significant pain inhibitory effects at 6 and 12 mg/kg doses (P < 0.05), but not at 3 mg/kg dose. Combining a low dose of choline (6 mg/kg) and parecoxib sodium (3 mg/kg) produced significant pain inhibition in CCI rats, and also reduced the expression of HMGB1 and NF-κBp65 in L4-6 DRGs.
Conclusion
A combination of choline and parecoxib sodium may effectively relieve neuropathic pain, and the underlying mechanisms may involve an inhibition of HMGB1/TLR4/NF-κB signaling pathway in DRG neurons.
Interactive Online Educational Modules Increase HIV and STI Prevention Competency Among Medical Students
Authors: Grant William , Adan Matthew A. , Samurkas Christina A. , Benitez Jorge , Gray Brett , Carnevale Caroline , Gordon Rachel J. , Zucker Jason , Sobieszczyk Magdalena E. 
Published: March 2022

Abstract
Background: The rate of new HIV diagnoses in the United States continues to slowly decline, yet, men who have sex with men and transgender women remain disproportionately affected. Key to improving quality of prevention services are providers who are comfortable addressing concepts of HIV prevention and sexual health across the spectrum of gender identities and sexual orientations. It is important to begin HIV prevention and sexual health education before providers’ practice habits are established. To address this need, we developed interactive educational modules and tested their impact on HIV prevention knowledge and awareness in future providers. Methods: Sexual health providers at an academic hospital, research clinicians, community engagement professionals, and New York City community members were consulted to develop seven educational modules, which were piloted among medical students. Knowledge of HIV and sexually transmitted infection (STI) prevention and comfort assessing prevention needs of various patients were assessed via online questionnaires administered before and after our educational intervention. Results: Pre- and post-module surveys were completed by 125 and 89 students, respectively, from all four years of training. Before the intervention, the majority of students had heard of HIV pre-exposure prophylaxis ( PrEP) (99.2%) and post-exposure prophylaxis (PEP) (92.7%). About 31% (38/123) of students agreed that they could confidently identify a patient who is a candidate for PrEP or PEP – this increased to 91% (81/89) following intervention. Conclusions: Our findings highlight a need for increased HIV and STI prevention training in medical school curricula to enable future providers to care for diverse, at-risk patient populations. Interactive modules offer an effective way to teach these concepts.
Microbiological Profile and Infection Potential of Different Cryopreserved Skull Flaps After Decompressive Hemicraniectomy. Is Cryopreservation at -80°C Better?
Authors: Agrawal Rachit , Rompf Csilla , Pranada AB , Vollmar P , De Lorenzo A , Hoyer A , Gousias K 
Published: March 2022

Abstract
Objective:Patterns of cryopreservation of explanted skull bone flaps have long been a matter of debate, in particular the appropriate temperature of storage. To the best of our knowledge no study to date has compared the microbiological profile and the infection potential of skull bone flaps cryostored at the same institution at disparate degrees for neurosurgical purposes. In the context of our clinical trial DRKS00023283, we performed a bacterial culture of explanted skull bone flaps, which were cryoasserved lege artis at a temperature of either -23°C or -80°C after a decompressive hemicraniectomy. In a further step, we contaminated the bone fragments in a suspension with specific pathogens (S.aureus, S.epidermidis and C.acnes, CFU 103/ml) over 24 hours and conducted a second culture.Results: A total of 17 cryopreserved skull flaps (8: -23°C; 9: -80°C) explanted during decompressive hemicraniectomies performed between 2019 and 2020 as well as 2 computer-aided-designed skulls (1 vancomycin-soaked) were analyzed. Median duration of cryopreservation was 10.5 months (2 to 17 months). No microorganisms were detected at the normal bacterial culture. After active contamination of our skull flaps, all samples showed similar bacterial growth of above-mentioned pathogens; thus, our study did not reveal an influence of the storage temperature upon infectious dynamic of the skulls.
Geographic inequalities in pediatric emergency department visits in Ontario and Alberta: a multilevel analysis of 2.5 million visits
Authors: Wilk Piotr , Maltby Alana , Lau Tammy , Gunz Anna C , Osornio-Vargas Alvaro , Yamamoto Shelby S , Ali Shehzad , Lavigne Éric 
Published: March 2022

Abstract
Background: Research on intra- and inter-regional variations in emergency department (ED) visits among children can provide a better understanding of the patterns of ED utilization and further insight into how contextual features of the urban environment may be associated with these health events. To assess intra-urban and inter-urban variation in pediatric emergency department (PED) visits in census metropolitan areas (CMAs) in Ontario and Alberta, Canada and explore if contextual factors related to material and social deprivation, proximity to healthcare facilities, and supply to family physicians explain this variation.Methods: A retrospective, population-based analysis of data on PED visits recorded between April 1, 2015 and March 31, 2017 was conducted. Random intercept multilevel regression models were constructed to quantify the intra- (between forward sortation areas [FSAs]) and inter- (between CMAs) variations in the rates of PED visits.Results: In total, 2,537,442 PED visits were included in the study. The overall crude FSA-level rate of PED visits was 415.38 per 1,000 children population. Across both provinces’ CMAs, the crude rate of PED visits was highest in Thunder Bay, Ontario (771.65) and lowest in Windsor, Ontario (237.19). There was evidence of statistically significant and substantial intra- and inter-urban variation in the rates of PED visits. More socially deprived FSAs, FSAs with lower proximity to healthcare facilities, and CMAs with a higher rate of family physicians per 1,000 children population had higher rates of PED visits.Conclusions: The variation in rates of PED visits across CMAs and FSAs cannot fully be accounted for by age and sex distributions, material and social deprivation, proximity to healthcare facilities, or supply of family physicians. There is a need to explore additional contextual factors to better understand why some metropolitan areas have higher rates of PED visits.
Are Temperament and Personality Redundant? A Longitudinal Comparison of Predictions With Childhood and Adulthood Personality
Authors: Wright Amanda J. , Jackson Joshua J. 
Published: March 2022

Abstract
Debate has long surrounded whether temperament and personality are distinct sets of individual differences or are rather two sides of the same coin. To the extent that there are differences, it could indicate important developmental insights concerning the mechanisms responsible for linking traits with outcomes. One way to test this is to examine the joint and incremental predictive validity of temperament and personality in the same individuals across time. Using a longitudinal sample spanning three decades starting infancy and followed up to 37 years old (N = 7,081), we ran a series of Bayesian generalized linear models with measures of childhood temperament and adult-based personality to predict outcomes in several life domains. Results indicated that while each set of individual differences were often related to the same outcomes, there were instances in which temperament provided incremental validity above adult personality, ranging from 2%-10% additional variance explained. Temperament explained the most variance for outcomes such as cognitive ability and educational attainment whereas personality performed best for outcomes such as health status, substance use, and most internalizing outcomes. These findings indicate temperament and personality assessments are not redundant and that a lifespan approach is needed to understand fully understand life outcomes.
Distributed coordinated attitude tracking control of spacecraft formation with dynamic leader under communication delays
Authors: Zhou Zhanjie , Zhang Zhihao , Wang Yan 
Published: March 2022

Abstract
This paper is dedicated to the challenging issue of the cooperative attitude tracking control of spacecraft formations under communication delays. A state estimator using the attitude information of the neighbors is designed for each follower spacecraft to estimate the time-varying attitude information of the leader spacecraft in the case that the leader spacecraft cannot directly communicate with all following spacecraft. By constructing auxiliary variables based on estimated values and proposing a fixed-time control law to ensure that the auxiliary variables of the spacecraft can reach zero in fixed time, which is independent of the initial state, the effects of time-varying reference attitudes on the system can be reduced. The attitude error and the estimation error are proven to converge to the region containing the origin by input-to-state stability theory combined with the Lyapunov-Krasovskii approach. To further illustrate the effectiveness of the proposed control algorithm, numerical simulation results are presented.
Prognostic Value of Myopic Disc Deformation in Myopic Choroidal Neovascularization: A 6-year Follow-up Study
Authors: Han Ye Eun , Kim Yoon Jeon , Yang Hyun Seung , Moon Byung Gil , Lee Joo Yong , Kim June-Gone , Yoon Young Hee 
Published: March 2022

Abstract
Purpose: To evaluate the clinical characteristics of myopic choroidal neovascularization (mCNV) with myopic disc deformations and explore whether myopic disc features are associated with the prognosis of mCNV. Methods: Patients with subfoveal mCNV who received anti-vascular endothelial growth factor (VEGF) and followed for > 3 years were included. Myopic disc deformations were quantified as the tilt ratio (the longest/shortest disc diameter), area of the ß-zone peripapillary atrophy (PPA), and ß-PPA/disc area ratio (PDR). We compared the clinical characteristics in terms of myopic disc features and identified the prognostic factors using Cox regression analysis. Results: Among a total of 80 eyes (50 with disc tilt), 29 (36.3%) eyes developed macular atrophy during 80.7 ± 34.8 months. Patients with disc tilt required more frequent anti-VEGF (P=0.044) and had worse final visual acuity (VA) (P=0.011) and a higher incidence of macular atrophy (P=0.015). Larger PDR, which had a strong correlation with large tilt ratio (P=0.006), showed significant correlations with longer axial length (P=0.006), worse VA (P=0.012), and thinner subfoveal choroidal thickness (P=0.015). Large PDR was a risk factor for macular atrophy (HR=2.257, P<0.001) and poor visual outcome (HR=1.407, P=0.015)Conclusion: Subfoveal mCNV with myopic disc deformations had worse functional and structural outcomes.
Glacier Fluctuations in the Northern Patagonian Andes (44°S) Imply Wind-Modulated Interhemispheric in Phase Paleoclimates During Termination 1
Authors: Soteres Rodrigo L , Sagredo Esteban A , Kaplan Michael R , Martini Mateo A , Moreno Patricio I , Reynhout Scott A , Schwartz Roseanne , Schaefer Joerg M 
Published: March 2022

Abstract
The Last Glacial Termination (T1) featured major changes in global circulation systems that led to a shift from glacial to interglacial climate. While polar ice cores attest to an antiphased thermal pattern at millennial timescales, recent well-dated moraine records from both hemispheres suggest in-phase fluctuations in glaciers through T1, which is inconsistent with the bipolar see-saw paradigm. Here, we present a glacier chronology based on 30 new 10Be surface exposure ages from well-preserved moraines in the Lago Palena/General Vintter basin in northern Patagonia (~44°S). We find that local glacier lobe underwent profound retreat after 19.7±0.7 ka. This recessional trend led to the individualization of the Cerro Riñón glacier by ~16.3 ka, which readvanced at 15.9±0.7 ka during Heinrich Stadial 1; during the Antarctic Cold Reversal with successive maxima at 13.5±0.6, 13.1±0.5, and 13.1±0.5 ka; and a minor culmination at 12.5±0.4 ka during Younger Dryas time. We conclude that fluctuations of Patagonian glaciers during T1 were controlled primarily by climate anomalies brought by shifts on the Southern Westerly Winds (SWW) locus. We posit that the global covariation of mountain glaciers during T1 was linked to variations in atmospheric CO2 promoted by the interplay of the SWW-Southern Ocean system at millennial timescales.