bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generalised hydrodynamics of particle creation and decay
Authors: Castro-Alvaredo Olalla A. , De Fazio Cecilia , Doyon Benjamin , Ziółkowska Aleksandra A. 
Published: April 2022

Abstract
Unstable particles rarely feature in conjunction with integrability in 1+1D quantum field theory. However, the family of homogenous sine-Gordon models provides a rare example where both stable and unstable bound states are present in the spectrum whilst the scattering matrix is diagonal and solves the usual bootstrap equations. In the standard scattering picture, unstable particles result from complex poles of the S-matrix located in the unphysical sheet of rapidity space. Since they are not part of the asymptotic spectrum, their presence is only felt through the effect they have on physical quantities associated either to the theory as a whole (i.e. scaling functions, correlation functions) or to the stable particles themselves (i.e. energy/particle density). In two recent publications, the effect of unstable particles in different out-of-equilibrium settings has been studied. It has been shown that their presence is associated with specific signatures in many quantities of physical interest. A good way to select those quantities is to adopt the generalised hydrodynamic approach and to consider the effective velocities and particle densities of the stable particles in the theory. For an initial state given by a spacial gaussian profile of temperatures peaked at the origin, time evolution gives rise to particle and spectral particle densities that exhibit hallmarks of the creation and decay of unstable particles. While these signatures have been observed numerically elsewhere, this paper explores their quantitative and qualitative dependence on the parameters of the problem. We also consider other initial states characterised by “inverted gaussian” and “double gaussian” temperature profiles.
Towards color-kinematics duality in generic spacetimes
Authors: Sivaramakrishnan Allic 
Published: April 2022

Abstract
In this note, we study color-kinematics duality in generic spacetimes. We work with a contact representation for on shell correlators. The position-space integrand is encoded by enumerated differential operators. This setup generalizes certain features of S-matrix kinematics to curved space. Differences between flat and curved space are captured by commutators. We study the nonlinear sigma model at four points as an explicit example and find that color-kinematics duality holds in generic spacetimes. We illustrate our approach in the AdS transition amplitude, a type of on shell correlation function. We find a double copy procedure at four points that connects the nonlinear sigma model, the biadjoint scalar theory, and the special Galileon theory.
Symmetry breaking to Majorana Brown-Susskind metric
Authors: Freedman Michael , Zini Modjtaba Shokrian 
Published: April 2022

Abstract
In parts I [1] and II [2] of our earlier work, we studied how metrics gij on $$ \mathfrak{su} $$
su
(n) may spontaneously break symmetry and crystallize into a form which is kaq, knows about qubits. We did this for n = 2N and then away from powers of 2. Here we address the Fermionic version and find kam metrics, these know about Majoranas. That is, there is a basis of principal axes {Hk} of which is of homogeneous Majorana degree. In part I, we searched unsuccessfully for functional minima representing crystallized metrics exhibiting the Brown-Susskind penalty schedule, motivated by their study of black hole scrambling time. Here, by segueing to the Fermionic setting we find, to good approximation, kam metrics adhering to this schedule on both $$ \mathfrak{su} $$
su
(4) and $$ \mathfrak{su} $$
su
(8). Thus, with this preliminary finding, our toy model exhibits two of the three features required for the spontaneous emergence of spatial structure: (1) localized degrees of freedom and, (2) a preference for low body-number (or low Majorana number) interactions. The final feature, (3) constraints on who may interact with whom, i.e. a neighborhood structure, must await an effective analytic technique, being entirely beyond what we can approach with classical numerics.
Angehörigenbetreuung auf Intensivstationen
Authors: Hoffmann Magdalena , Nydahl Peter , Brauchle Maria , Schwarz Christine , Amrein Karin , Jeitziner Marie-Madlen 
Published: April 2022

Zusammenfassung
Hintergrund
Angehörige von kritisch Kranken auf der Intensivstation („intensive care unit“, ICU) sind in einer herausfordernden Situation: Sie befinden sich häufig in einer existenziellen Krise mit einer großen emotionalen Belastung, gleichzeitig sind sie oftmals aktiv in therapeutische Entscheidungen mit eingebunden. Die Besuchsrestriktionen während der Pandemie aufgrund der Coronaviruserkrankung 2019 (COVID-19) haben viele Rahmenbedingungen für die Angehörigenbegleitung geändert und so die Betreuung von Angehörigen schwieriger gemacht.

Ziel
Ziel der Publikation ist die Darstellung der aktuellen und neuen Entwicklungen in der Angehörigenbegleitung von kritisch Kranken auf Intensivstationen im Rahmen einer narrativen Übersichtsarbeit.

Ergebnisse
In den letzten Jahren wurden zahlreiche Maßnahmen und Projekte zur Angehörigenbegleitung entwickelt, die sich den folgenden 6 Bereichen zuordnen lassen: 1) Anwesenheit der Angehörigen, 2) proaktive Einbindung in die Betreuung, 3) strukturierte Kommunikation und Information sowie Onlineangebote, 4) multidisziplinäre Zusammenarbeit, 5) Aufgaben der Organisationsleitung und 6) Follow-up-Angebote. Die Evidenz und der derzeitige Implementierungsstand der Maßnahmen sind international und national sehr heterogen.

Schlussfolgerungen
Maßnahmen zur Angehörigenbetreuung sind vielfältig und können zum Teil auch unter Besuchsrestriktionen umgesetzt werden. Neuere Entwicklungen im digitalen Bereich ermöglichen zunehmend auch virtuelle Besuche und einen ergänzenden Informationsaustausch zwischen dem Team der ICU und den Angehörigen.
The supply of foreign talent: how skill-biased technology drives the location choice and skills of new immigrants
Authors: Beerli Andreas , Indergand Ronald , Kunz Johannes S. 
Published: April 2022

AbstractAn important goal of immigration policy is facilitating the entry of foreign-born workers whose skills are in short supply in destination labor markets. In recent decades, information and communication technology (ICT) has fueled the demand for highly educated workers at the expense of less-educated groups. Exploiting the fact that regions in Switzerland have been differentially exposed to ICT due to their pre-ICT industrial composition, we present evidence suggesting that more exposed regions experienced stronger ICT adoption, accompanied by considerably stronger growth in relative employment and wage premia for college-educated workers. Following this change in the landscape of relative economic opportunities, we find robust evidence that these regions experienced a much larger influx of highly educated immigrants in absolute terms as well as relative to lower educated groups. Our results suggest that immigrants’ location decisions respond strongly to these long-run, technology-driven changes in their economic opportunities.
Hölder classes via semigroups and Riesz transforms
Authors: González-Pérez Adrián 
Published: April 2022

AbstractWe define Hölder classes$$\Lambda _\alpha $$Λαassociated with a Markovian semigroup and prove that, when the semigroup satisfies the$$\Gamma ^2 \ge 0$$Γ2≥0condition, the Riesz transforms are bounded between the Hölder classes. As a consequence, this bound holds in manifolds with nonnegative Ricci curvature. We also show, without the need for extra assumptions on the semigroup, that a version of the Morrey inequalities is equivalent to the ultracontractivity property. This result extends the semigroup approach to the Sobolev inequalities laid by Varopoulos. After that, we study certain families of operators between the homogeneous Hölder classes. One of these families is given by analytic spectral multipliers and includes the imaginary powers of the generator, the other, by smooth multipliers analogous to those in the Marcienkiewicz theorem. Lastly, we explore the connection between the Hölder norm and Campanato’s formula for semigroups.
The Willmore Center of Mass of Initial Data Sets
Authors: Eichmair Michael , Koerber Thomas 
Published: April 2022

AbstractWe refine the Lyapunov–Schmidt analysis from our recent paper (Eichmair and Koerber in Large area-constrained Willmore surfaces in asymptotically Schwarzschild 3-manifolds. arXiv preprint arXiv:2101.12665, 2021) to study the geometric center of mass of the asymptotic foliation by area-constrained Willmore surfaces of initial data for the Einstein field equations. If the scalar curvature of the initial data vanishes at infinity, we show that this geometric center of mass agrees with the Hamiltonian center of mass. By contrast, we show that the positioning of large area-constrained Willmore surfaces is sensitive to the distribution of the energy density. In particular, the geometric center of mass may differ from the Hamiltonian center of mass if the scalar curvature does not satisfy additional asymptotic symmetry assumptions.
On Holobionts, Holospecies, and Holoniches: the Role of Microbial Symbioses in Ecology and Evolution
Authors: Koide Roger T. 
Published: April 2022

AbstractMy goal in writing this is to increase awareness of the roles played by microbial symbionts in eukaryote ecology and evolution. Most eukaryotes host one or more species of symbiotic microorganisms, including prokaryotes and fungi. Many of these have profound impacts on the biology of their hosts. For example, microbial symbionts may expand the niches of their hosts, cause rapid adaptation of the host to the environment and re-adaptation to novel conditions via symbiont swapping, facilitate speciation, and fundamentally alter our concept of the species. In some cases, microbial symbionts and multicellular eukaryote hosts have a mutual dependency, which has obvious conservation implications. Hopefully, this contribution will stimulate a reevaluation of important ecological and evolutionary concepts including niche, adaptation, the species, speciation, and conservation of multicellular eukaryotes.
A global evaluation of advanced dosimetry in transarterial radioembolization of hepatocellular carcinoma with Yttrium-90: the TARGET study
Authors: Lam Marnix , Garin Etienne , Maccauro Marco , Kappadath S. Cheenu , Sze Daniel Y. , Turkmen Cuneyt , Cantasdemir Murat , Haste Paul , Herrmann Ken , Alsuhaibani Hamad Saleh , Dreher Matthew , Fowers Kirk D. , Salem Riad 
Published: April 2022

Abstract

Purpose
To investigate the relationships between tumor absorbed dose (TAD) or normal tissue absorbed dose (NTAD) and clinical outcomes in hepatocellular carcinoma (HCC) treated with yttrium-90 glass microspheres.

Methods
TARGET was a retrospective investigation in 13 centers across eight countries. Key inclusion criteria: liver-dominant HCC with or without portal vein thrombosis, < 10 tumors per lobe (at least one ≥ 3 cm), Child–Pugh stage A/B7, BCLC stages A–C, and no prior intra-arterial treatment. Multi-compartment pre-treatment dosimetry was performed retrospectively. Primary endpoint was the relationship between ≥ grade 3 hyperbilirubinemia (such that > 15% of patients experienced an event) without disease progression and NTAD. Secondary endpoints included relationships between (1) objective response (OR) and TAD, (2) overall survival (OS) and TAD, and (3) alpha fetoprotein (AFP) and TAD.

Results
No relationship was found between NTAD and ≥ grade 3 hyperbilirubinemia, which occurred in 4.8% of the 209 patients. The mRECIST OR rate over all lesions was 61.7%; for the target (largest) lesion, 70.8%. Responders and non-responders had geometric mean total perfused TADs of 225.5 Gy and 188.3 Gy (p = 0.048). Probability of OR was higher with increasing TAD (p = 0.044). Higher TAD was associated with longer OS (HR per 100 Gy increase = 0.83, 95% CI: 0.71–0.95; p = 0.009). Increased TAD was associated with higher probability of AFP response (p = 0.046 for baseline AFP ≥ 200 ng/mL).

Conclusion
Real-world data confirmed a significant association between TAD and OR, TAD and OS, and TAD and AFP response. No association was found between ≥ grade 3 hyperbilirubinemia and NTAD.

Trial registration number
NCT03295006.
Fully automated AI-based splenic segmentation for predicting survival and estimating the risk of hepatic decompensation in TACE patients with HCC
Authors: Müller Lukas , Kloeckner Roman , Mähringer-Kunz Aline , Stoehr Fabian , Düber Christoph , Arnhold Gordon , Gairing Simon Johannes , Foerster Friedrich , Weinmann Arndt , Galle Peter Robert , Mittler Jens , Pinto dos Santos Daniel , Hahn Felix 
Published: April 2022

Abstract
Objectives
Splenic volume (SV) was proposed as a relevant prognostic factor for patients with hepatocellular carcinoma (HCC). We trained a deep-learning algorithm to fully automatically assess SV based on computed tomography (CT) scans. Then, we investigated SV as a prognostic factor for patients with HCC undergoing transarterial chemoembolization (TACE).

Methods
This retrospective study included 327 treatment-naïve patients with HCC undergoing initial TACE at our tertiary care center between 2010 and 2020. A convolutional neural network was trained and validated on the first 100 consecutive cases for spleen segmentation. Then, we used the algorithm to evaluate SV in all 327 patients. Subsequently, we evaluated correlations between SV and survival as well as the risk of hepatic decompensation during TACE.

Results
The algorithm showed Sørensen Dice Scores of 0.96 during both training and validation. In the remaining 227 patients assessed with the algorithm, spleen segmentation was visually approved in 223 patients (98.2%) and failed in four patients (1.8%), which required manual re-assessments. Mean SV was 551 ml. Survival was significantly lower in patients with high SV (10.9 months), compared to low SV (22.0 months, p = 0.001). In contrast, overall survival was not significantly predicted by axial and craniocaudal spleen diameter. Furthermore, patients with a hepatic decompensation after TACE had significantly higher SV (p < 0.001).

Conclusion
Automated SV assessments showed superior survival predictions in patients with HCC undergoing TACE compared to two-dimensional spleen size estimates and identified patients at risk of hepatic decompensation. Thus, SV could serve as an automatically available, currently underappreciated imaging biomarker.

Key Points
• Splenic volume is a relevant prognostic factor for prediction of survival in patients with HCC undergoing TACE, and should be preferred over two-dimensional surrogates for splenic size.
• Besides overall survival, progression-free survival and hepatic decompensation were significantly associated with splenic volume, making splenic volume a currently underappreciated prognostic factor prior to TACE.
• Splenic volume can be fully automatically assessed using deep-learning methods; thus, it is a promising imaging biomarker easily integrable into daily radiological routine.
Assessing the relative accuracy of coral heights reconstructed from drones and structure from motion photogrammetry on coral reefs
Authors: Casella E. , Lewin P. , Ghilardi M. , Rovere A. , Bejarano S. 
Published: April 2022

AbstractLow-altitude high-resolution aerial photographs allow for the reconstruction of structural properties of shallow coral reefs and the quantification of their topographic complexity. This study shows the scope and limitations of two-media (air/water) Structure from Motion—Multi-View Stereo reconstruction method using drone aerial photographs to reconstruct coral height. We apply this method in nine different sites covering a total area of about 7000 m2, and we examine the suitability of the method to obtain topographic complexity estimates (i.e., seafloor rugosity). A simple refraction correction and survey design allowed reaching a root mean square error of 0.1 m for the generated digital models of the seafloor (without the refraction correction the root mean square error was 0.2 m). We find that the complexity of the seafloor extracted from the drone digital models is slightly underestimated compared to the one measured with a traditional in situ survey method.
Patient and pathological predictors of management strategy for malignant polyps following polypectomy: a systematic review and meta-analysis
Authors: Zammit Andrew P. , Lyons Nicholas J. , Chatfield Mark D. , Hooper John D. , Brown Ian , Clark David A. , Riddell Andrew D. 
Published: April 2022

Abstract
Purpose
Malignant polyps present a treatment dilemma for clinicians and patients. This meta-analysis sought to identify the factors that predicted the management strategy for patients diagnosed with a malignant polyp.

Methods
A literature search was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and the Cochrane Collaboration prognostic studies guidelines. Reports from 1985 onwards were included, data on patient and pathological factors were extracted and random effects meta-analysis models were used.

Results
Fifteen studies were included. Seven studies evaluated lymphovascular invasion (LVI). The odds of surgery were significantly higher in malignant polyps with LVI (OR 2.20, 95% CI 1.36–3.55). Ten studies revealed the odds of surgery were significantly higher with positive polypectomy margins (OR 8.09, 95% CI 4.88–13.40). Tumour differentiation was compared in eight studies. There were significantly lower odds of surgery in malignant polyps with well/moderate differentiation compared with poor differentiation (OR 0.31, 95% CI 0.21–0.46). There were non-significant trends favouring surgical resection in younger patients, males and Haggitt 4/Kikuchi Sm3 lesions. There was considerable heterogeneity in the meta-analyses for the variables age, gender, polyp morphology and Haggitt/Kikuchi level (I2 > 75%).

Conclusion
This meta-analysis has demonstrated that LVI, positive polypectomy resection margins, and poor tumour differentiation significantly predict malignant polypectomy patients who underwent subsequent surgery. Age and gender were important factors predicting management, but not consistently across studies, whilst polyp morphology and Haggitt/Kikuchi levels did not significantly predict the management strategy. Further research may assist in understanding the management preferences.
Guideline adherence and implementation of tumor board therapy recommendations for patients with gastrointestinal cancer
Authors: Krause Alina , Stocker Gertraud , Gockel Ines , Seehofer Daniel , Hoffmeister Albrecht , Bläker Hendrik , Denecke Timm , Kluge Regine , Lordick Florian , Knödler Maren 
Published: April 2022

Abstract
Purpose
Although participation in multidisciplinary tumor boards (MTBs) is an obligatory quality criterion for certification, there is scarce evidence, whether MTB recommendations are consistent with consensus guidelines and whether they are followed in clinical practice. Reasons of guideline and tumor board deviations are poorly understood so far.

Methods
MTB’s recommendations from the weekly MTB for gastrointestinal cancers at the University Cancer Center Leipzig/Germany (UCCL) in 2020 were analyzed for their adherence to therapy recommendations as stated in National German guidelines and implementation within an observation period of 3 months. To assess adherence, an objective classification system was developed assigning a degree of guideline and tumor board adherence to each MTB case. For cases with deviations, underlying causes and influencing factors were investigated and categorized.

Results
76% of MTBs were fully adherent to guidelines, with 16% showing deviations, mainly due to study inclusions and patient comorbidities. Guideline adherence in 8% of case discussions could not be determined, especially because there was no underlying guideline recommendation for the specific topic. Full implementation of the MTBs treatment recommendation occurred in 64% of all cases, while 21% showed deviations with primarily reasons of comorbidities and differing patient wishes. Significantly lower guideline and tumor board adherences were demonstrated in patients with reduced performance status (ECOG-PS ≥ 2) and for palliative intended therapy (p = 0.002/0.007).

Conclusions
The assessment of guideline deviations and adherence to MTB decisions by a systematic and objective quality assessment tool could become a meaningful quality criterion for cancer centers in Germany.
Development and consensus process for a clinical pathway for the assessment and management of chemotherapy-induced peripheral neuropathy
Authors: Mizrahi David , Goldstein David , Kiernan Matthew C. , Robinson Louisa , Pitiyarachchi Omali , McCullough Susan , Mendoza-Jones Phil , Grimison Peter , Boyle Frances , Park Susanna B. 
Published: April 2022

Abstract
Background
Cancer patients treated with neurotoxic chemotherapy are at risk of developing neurological symptoms that can impact functional capacity and quality of life. However, there are no standardised pathways to assess and manage chemotherapy-induced peripheral neurotoxicity (CIPN). This study aimed to determine consensus on statements regarding a CIPN assessment and management clinical pathway.

Methods
A CIPN clinical pathway (CIPN-path) was developed and reviewed by an expert multi-disciplinary panel and consumers. Agreement with 18 statements regarding four content themes (pretreatment review, screening and assessment, management and referral, and CIPN-path feasibility) were assessed by 70 Australian respondents (68 health professionals, 2 consumers), using a 2-stage Delphi survey process to reach consensus. Respondents rated statements using a 5-point Likert scale to determine the level of agreement, with consensus defined as ≥ 80% of respondents agreeing with each statement.

Results
The consensus was reached for 14 of 18 items after stage 1 and all items after stage 2. Feedback was obtained for all items to refine the CIPN-path. There was an agreement on important characteristics of the CIPN-path, including pretreatment screening, regular patient-reported assessment, and a stepped-care approach to investigating and managing symptom burden. There was a lack of agreement on who should oversee CIPN assessment, which may differ according to the structure and resources of each site.

Conclusions
There was an overall agreement concerning the CIPN-path to assess and manage CIPN, which may be adapted accordingly to the resources of each clinic. The CIPN-path may assist teams across different health services in identifying CIPN symptoms, aiding decision-making, and reducing morbidity from CIPN.