bluuebunny/crossref_metadata_2025_split huggingface dataset:
AdS Virasoro-Shapiro from dispersive sum rules
Authors: Alday Luis F. , Hansen Tobias , Silva Joao A. 
Published: October 2022

Abstract
We consider the four-point correlator of the stress-energy tensor in $$ \mathcal{N} $$
N
= 4 SYM, to leading order in inverse powers of the central charge, but including all order corrections in 1/λ. This corresponds to the AdS version of the Virasoro-Shapiro amplitude to all orders in the small α′/low energy expansion. Using dispersion relations in Mellin space, we derive an infinite set of sum rules. These sum rules strongly constrain the form of the amplitude, and determine all coefficients in the low energy expansion in terms of the CFT data for heavy string operators, in principle available from integrability. For the first set of corrections to the flat space amplitude we find a unique solution consistent with the results from integrability and localisation.
Sextic tensor model in rank 3 at next-to-leading order
Authors: Harribey Sabine 
Published: October 2022

Abstract
We compute the four-loop beta functions of short and long-range multi-scalar models with general sextic interactions and complex fields. We then specialize the beta functions to a U(N)3 symmetry and study the renormalization group at next-to-leading order in N and small ϵ. In the short-range case, ϵ is the deviation from the critical dimension while it is the deviation from the critical scaling of the free propagator in the long-range case. This allows us to find the 1/N corrections to the rank-3 sextic tensor model of [1]. In the short-range case, we still find a non-trivial real IR stable fixed point, with a diagonalizable stability matrix. All couplings, except for the so-called wheel coupling, have terms of order ϵ0 at leading and next-to-leading order, which makes this fixed point different from the other melonic fixed points found in quartic models. In the long-range case, the corrections to the fixed point are instead not perturbative in ϵ and hence unreliable; we thus find no precursor of the large-N fixed point.
A phase-field study of neck growth in electron beam powder bed fusion (EB-PBF) process of Ti6Al4V powders under different processing conditions
Authors: Rizza Giovanni , Galati Manuela , Iuliano Luca 
Published: October 2022

AbstractTraditional sintering processes are carried out to achieve complete material densification. In an electron beam powder bed fusion (EB-PBF) process, the same sintering mechanisms occur but only with the aim to form small connections between the particles (necks). A proper neck formation is central for the EB-PBF process because, among other effects, ensures the thermal stability of the process and helps to avoid smoke phenomena. This work presents a numerical study of neck formation under the EB-PBF processing conditions. A new type of modelling is introduced for the temperature sintering load and included in a phase-field model, which simulates the neck growth during the EB-PBF process of Ti6Al4V powders. The model was validated with an ad-hoc experiment, which provided a deviation with respect to the estimated neck diameter of about 9%. The deviation was investigated by reasonably varying the processing conditions. The results showed that the thermal history, the process time scale (including also the cooling phase), and the geometrical characteristics of the particles significantly affected the sintering rate and neck radius.
Accurate 24-h urine cystine quantification for patients on cystine-binding thiol drugs
Authors: Mikel Charles C. , Goldfarb David S. , Ponte Amy , Steigelman Katherine , Latyshev Sergey 
Published: October 2022

AbstractCystinuria is a rare disorder resulting in development of recurrent kidney stones, adversely affecting patient quality of life. The goal of cystinuria management is to reduce stone formation by increasing cystine solubility in urine, which includes lowering the urinary cystine level below its solubility limit. Treatment usually involves alkalinization of the urine and often requires initiating pharmacotherapy with a cystine-binding thiol drug (CBTD) such as tiopronin; however, proper dose adjustment requires accurate measurement of urinary cystine. The goal of this study was to validate a novel high-performance liquid chromatography tandem mass spectrometry (HPLC–MS/MS) method for quantification of cystine in the urine of patients with cystinuria receiving a CBTD. Urine samples were collected over 24 h from 24 patients and separated into 2 aliquots. Chromatographic separation of samples was conducted and separation of cystine from the cysteine-tiopronin drug complex was complete in < 3 min. The method was validated for accuracy, precision, linearity, limit of detection (LOD), and limit of quantification (LOQ). Mean accuracy range was 97.7–102.3%; intermediate precision was high with relative percent difference values calculated at 1.2–9.3%; the calibration curve resulted in a linear response throughout the concentration range (R2 = 0.998); and the LOD and LOQ were 0.002 and 0.005 mg/mL, respectively. Mean (range) cystine concentrations measured were 111.10 (51.31–179.46) and 242.21 (61.14–741.80) g/L in Aliquots A and B, respectively. The HPLC–MS/MS method presented here indicates that urine cystine can be reliably quantified in patients receiving a CBTD.
Heightened 30‐Day Postoperative Complication Risk Persists After COVID‐19 Infection
Authors: Neumaier Mackenzie , Thirukumaran Caroline , Ramirez Gabriel , Ricciardi Benjamin 
Published: October 2022

AbstractBackgroundCurrent literature describing the riskiness of operating on actively infected COVID‐19 patients far outnumbers that on the risk of operating on recovered patients. The purpose of this study was to analyze a single, tertiary referral center experience regarding postoperative complications and readmissions in COVID‐19‐recovered patients versus COVID‐19‐naïve (never previously infected) patients undergoing elective and emergency surgery across all surgical subspecialties.MethodsAll PCR positive COVID‐19 patients that underwent a surgical procedure between February 1, 2020, and November 1, 2020, were included in the COVID‐positive cohort. These patients were then matched to COVID‐naïve controls that underwent similar procedures within the same time frame. Primary outcomes included 30‐day postoperative complications as well as 90‐day readmissions. Multivariable analyses were also performed.Results112 COVID‐positive patients met inclusion criteria and were all matched to COVID‐naïve controls. 76 patients (68%) underwent surgery > 30 days from their COVID diagnosis. COVID‐positive patients were at significantly higher risk of 30‐day complications compared to the COVID‐naïve cohort (22% versus 8%, respectively; p < 0.01). Multivariable analyses found ambulatory/asymptomatic infections, undergoing surgery between 30 and 120 days from diagnosis, initial presentation to the emergency department and elevated ASA scores to be significantly associated with 30‐day complications. No differences were found for 90‐day readmissions.ConclusionPatients with previous COVID‐19 infections carry a higher perioperative risk profile for 30‐day complications compared to COVID‐naïve counterparts in unvaccinated populations.
Glucose variability increases during minimally invasive procedures in very preterm infants
Authors: Galderisi Alfonso , Res Giulia , Guiducci Silvia , Savio Federica , Brigadoi Sabrina , Forlani Laura , Mastrandrea Biancamaria , Moschino Laura , Lolli Elisabetta , Priante Elena , Trevisanuto Daniele , Baraldi Eugenio 
Published: October 2022

AbstractThe objective of this study is to assess the effect of neonatal procedures on glucose variability in very preterm infants. Preterm infants (≤ 32 weeks gestation and/or birthweight ≤ 1500 g) were started on continuous glucose monitoring (CGM) on day 2 of birth and monitored for 5 days. Minimally invasive (heel stick, venipunctures) and non-invasive (nappy change, parental presence) procedures were recorded. CGM data were analyzed 30 min before and after each procedure. The primary outcome was the coefficient of glucose variation (CV = SD/mean) before and after the procedure; SD and median glucose were also evaluated. We analyzed 496 procedures in 22 neonates (GA 30.5 weeks [29–31]; birthweight 1300 g [950–1476]). Median glucose did not change before and after each procedure, while CV and SD increased after heel prick (p = 0.017 and 0.030), venipuncture (p = 0.010 and 0.030), and nappy change (p < 0.001 and < 0.001), in the absence of a difference during parental presence.Conclusions: Non-invasive and minimally invasive procedures increase glucose variability in the absence of changes of mean glucose.

What is Known:• Minimally invasive procedures - including nappy change - may increase neonatal stress in preterm infants.

What is New:• Continuous glucose monitoring provides a quantitative measure of neonatal stress during neonatal care procedures demonstrating an increase of glucose variability.
Indications for upper gastrointestinal endoscopy before bariatric surgery: a multicenter study
Authors: Abdallah Hussein , El Skalli Mehdi , Mcheimeche Hussein , Casagranda Biagio , de Manzini Nicolò , Palmisano Silvia 
Published: October 2022

Abstract
Background
The role of preoperative upper gastrointestinal endoscopy before bariatric surgery is still debated, and a consensus among the international scientific community is lacking. The aims of this study, conducted in three different geographic areas, were to analyze data regarding the pathological endoscopic findings and report their impact on the decision-making process and surgical management, in terms of delay in surgical operation, modification of the intended bariatric procedure, or contraindication to surgery.

Methods
This is a multicenter cross-sectional study using data obtained from three prospective databases. The preoperative endoscopic reports, patient demographics, Body Mass Index, type of surgery, and Helicobacter pylori status were collected. Endoscopic findings were categorized into four groups: (1) normal endoscopy, (2) abnormal findings not requiring a change in the surgical approach, (3) clinically important lesions that required a change in surgical management or further investigations or therapy prior to surgery, and (4) findings that contraindicated surgery.

Results
Between 2006 and 2020, data on 643 patients were analyzed. In all of the enrolled bariatric institutions, preoperative endoscopy was performed routinely. A total of 76.2% patients had normal and/or abnormal findings that did not required a change in surgical management; in 23.8% cases a change or a delay in surgical approach occurred. Helicobacter pylori infection was detected in 15.2% patients. No patient had an endoscopic finding contraindicating surgery.

Conclusions
The role of preoperative UGE is to identify a wide range of pathological findings in patients with obesity that could influence the therapeutic approach, including the choice of the proper bariatric procedure. Considering the anatomical modifications, the incidence of asymptomatic pathologies, and the risk of malignancy, we support the decision of performing preoperative endoscopy for all patients eligible for bariatric operation.

Graphical abstract
Frequency of cholelithiasis in need of surgical or endoscopic treatment a decade or more after Roux-en-Y gastric bypass
Authors: Belgau Ingrid , Johnsen Gjermund , Græslie Hallvard , Mårvik Ronald , Nymo Siren , Bjerkan Kirsti , Hyldmo Åsne , Klöckner Christian , Kulseng Bård , Hoff Dag , Sandvik Jorunn 
Published: October 2022

Abstract
Background
Symptomatic cholelithiasis requiring treatment is a known side effect after Roux-en-Y gastric bypass (RYGB), but reported rates vary greatly. The objectives for this study were to evaluate the long-term frequency of surgical or endoscopic treatment for symptomatic cholelithiasis 10–15 years after RYGB and its relation to self-reported abdominal pain.

Methods
Observational data from 546 patients who underwent RYGB at public hospitals in Central Norway between March 2003 and December 2009 were analyzed.

Results
Median follow-up was 11.5 (range 9.1–16.8) years. Sixty-five (11.9%) patients had undergone cholecystectomy prior to RYGB. Out of the 481 patients with intact gallbladder, 77 (16.0%) patients underwent cholecystectomy and six (1.2%) patients had treatment for choledocholithiasis during the observation period. Median time from RYGB to cholecystectomy or treatment of choledocholithiasis was 51 (range 1–160) and 109 (range 10–151) months, respectively. Female sex was associated with an increased risk of subsequent cholecystectomy [OR (95% CI) 2.88 (1.31–7.15)], p < 0.05. There was a higher frequency of self-reported abdominal pain at follow-up [OR (95% CI) 1.92 (1.25–2.93)] among patients who underwent cholecystectomy before or after RYGB.

Conclusion
With a median follow-up of more than 11 years after RYGB, one in six patients with an intact gallbladder at time of RYGB underwent cholecystectomy, and 1.1% of the patients needed surgical or endoscopic treatment for choledocholithiasis. Patients with a history of cholecystectomy reported a higher frequency of abdominal pain.
Implementation of the robotic abdominal phase during robot-assisted minimally invasive esophagectomy (RAMIE): results from a high-volume center
Authors: de Groot E. M. , Goense L. , Kingma B. F. , van den Berg J. W. , Ruurda J. P. , van Hillegersberg R. 
Published: October 2022

Abstract
Background
Evidence on the added value of robotic-assistance in the abdominal phase during esophagectomy is scarce. In 2003, our center implemented the robotic thoracic phase for esophagectomy. In November 2018 the robot was also implemented in the abdominal phase. The aim of this study was to evaluate the implementation of the abdominal phase during robot-assisted minimally invasive esophagectomy (RAMIE).

Methods
Consecutive patients who underwent full RAMIE with intrathoracic anastomosis for esophageal cancer were included. Patients were extracted from a prospectively maintained institutional database. A cumulative sum (CUSUM) analysis was performed for abdominal operation time and abdominal lymph node yield. Intraoperative, postoperative and oncological outcomes including collected lymph nodes per abdominal lymph node station were reported.

Results
Between 2018 and 2021, 70 consecutive patients were included. The majority of the patients had an adenocarcinoma (n = 55, 77%) and underwent neoadjuvant chemo(radio)therapy (n = 65, 95%). The median operative time for the abdominal phase was 180 min (range 110–233). The CUSUM analysis for abdominal operation time showed a plateau at case 22. There were no intraoperative complications or conversions during the abdominal phase. The most common postoperative complications were pneumonia (n = 18, 26%) and anastomotic leakage (n = 14, 20%). Radical resection margins were achieved in 69 (99%) patients. The median total lymph node yield was 42 (range 23–83) and the median abdominal lymph node yield was 16 (range 2–43). The CUSUM analysis for abdominal lymph node yield showed a plateau at case 21. Most abdominal lymph nodes were collected from the left gastric artery (median 4, range 0–20).

Conclusions
This study shows that a robotic abdominal phase was safely implemented for RAMIE without compromising intraoperative, postoperative and oncological outcomes. The learning curve is estimated to be 22 cases in a high-volume center with experienced upper GI robotic surgeons.
Posterior tibial slope (PTS) ≥ 10 degrees is a risk factor for further anterior cruciate ligament (ACL) injury; BMI is not
Authors: Fares Ali , Horteur Clément , Abou Al Ezz Morad , Hardy Alexandre , Rubens-Duval Brice , Karam Karam , Gaulin Benoit , Pailhe Regis 
Published: October 2022

Abstract
Purpose
This case–control study aimed to assess the influence of BMI and PTS on subsequent ACL injury affecting either ACL graft or the native ACL of the contralateral knee after primary ACL reconstruction.

Methods
A retrospective case–control study was performed using a cohort of patients who underwent arthroscopic ACL reconstruction between 2010 and 2020 using the same surgical procedure: Hamstring tendon autograft. The study group (group I) included all the patients (n = 94) during this period who sustained a subsequent ACL injury. The control group (group II) consisted of 94 patients randomly selected (matched Group I in terms of sex, age, and ACL graft) who did not sustain any further ACL injury. PTS was measured by two blinded surgeons on lateral knee view radiographs of the operated knee after primary ACL. BMI in kg/m2 was measured during the preoperative anesthesia consultation. Exclusion criteria were: non-true or rotated lateral knee radiographs of the operated knee post-ACLR, associated knee ligament injury requiring surgical management, iterative knee surgeries, open growth plate, and related fracture.

Results
The mean posterior tibial slope in group I was 7.5° ± 2.9, and 7.2° ± 2.0 in group II. A PTS angle cutoff was set at 10 degrees. The rate of patients showing a PTS ≥ 10° was significantly higher in group I compared to group II (p < 0.01). Patients with PTS ≥ 10° were 5.7 times more likely to sustain a subsequent ACL injury, (OR: 5.7 95% CI[1.858–17.486]). The Average BMI in group I was 24.5 ± 3.7 kg.m−2 compared to group II which was 23.3 ± 3.0 kg.m−2. There were no significant differences in any of the four BMI categories between both groups (p value 0.289). A series of BMI cut-offs were also analyzed at 23 to30 kg/m2, and there was no significant difference between both groups.

Conclusions
A posterior tibial slope equal to or above 10 degrees measured on lateral knee radiographs was associated with 5.7 times higher risk of ACL graft rupture or contralateral native ACL injury; however, BMI was not.
Efficacy, safety, and pharmacokinetics of teduglutide in adult Japanese patients with short bowel syndrome and intestinal failure: two phase III studies with an extension
Authors: Nakamura Shiro , Wada Motoshi , Mizushima Tsunekazu , Sugita Akira , Tazuke Yuko , Ohge Hiroki , Udagawa Eri , Suzuki Ryohsuke Ken , Yoon MinJung , Grimm Andrew , Chen Szu-Ta , Ikeuchi Hiroki 
Published: October 2022

Abstract
Purpose
The short- and long-term efficacy, safety, and pharmacokinetics of teduglutide were analyzed in adult Japanese patients with short bowel syndrome and intestinal failure (SBS-IF).

Methods
Patients received teduglutide 0.05 mg/kg/day in clinical trials (TED-C14-004, SHP633-306, and extension SHP633-307). Data were analyzed at 24 weeks and an interim data cut-off of 4.5 years.

Results
The parenteral support (PS) volume decreased by ≥ 20% for 9/18 patients at 24 weeks and in all 11 patients by data cut-off in SHP633-307. The mean (standard deviation) PS volume decreased from baseline at 24 weeks in TED-C14-004 (−30.1 ± 25.9%) and SHP633-306 (−25.6 ± 25.5%), and at data cut-off in SHP633-307 (−57.08 ± 28.49%). Teduglutide was absorbed quickly. The adverse events were consistent with the underlying disease and known adverse drug reactions. Anti-teduglutide antibody titers declined with long-term treatment.

Conclusions
In Japanese adults with SBS-IF, teduglutide treatment was associated with clinically meaningful reductions in PS requirements, similar to findings in prior international studies. No new safety concerns specific to the Japanese SBS-IF patient population were identified with short- or long-term teduglutide treatment. Anti-teduglutide antibody titers disappeared in most Japanese adults with long-term treatment. These results constitute the longest evaluation of teduglutide treatment within clinical trials reported to date.
The use of ecological analytical tools as an unconventional approach for untargeted metabolomics data analysis: the case of Cecropia obtusifolia and its adaptive responses to nitrate starvation
Authors: Cadena-Zamudio Jorge David , Monribot-Villanueva Juan Luis , Pérez-Torres Claudia-Anahí , Alatorre-Cobos Fulgencio , Jiménez-Moraila Beatriz , Guerrero-Analco José A. , Ibarra-Laclette Enrique 
Published: October 2022

Abstract
Plant metabolomics studies haves revealed new bioactive compounds. However, like other omics disciplines, the generated data are not fully exploited, mainly because the commonly performed analyses focus on elucidating the presence/absence of distinctive metabolites (and/or their precursors) and not on providing a holistic view of metabolomic changes and their participation in organismal adaptation to biotic and abiotic stress conditions. Therefore, spectral libraries generated from Cecropia obtusifolia cell suspension cultures in a previous study were considered as a case study and were reanalyzed herein. These libraries were obtained from a time-course experiment under nitrate starvation conditions using both electrospray ionization modes. The applied methodology included the use of ecological analytical tools in a systematic four-step process, including a population analysis of metabolite α diversity, richness, and evenness (i); a chemometrics analysis to identify discriminant groups (ii); differential metabolic marker identification (iii); and enrichment analyses and annotation of active metabolic pathways enriched by differential metabolites (iv). Our species α diversity results referring to the diversity of metabolites represented by mass-to-charge ratio (m/z) values detected at a specific retention time (rt) (an uncommon way to analyze untargeted metabolomic data) suggest that the metabolome is dynamic and is modulated by abiotic stress. A total of 147 and 371 m/z_rt pairs was identified as differential markers responsive to nitrate starvation in ESI− and ESI+ modes, respectively. Subsequent enrichment analysis showed a high degree of completeness of biosynthetic pathways such as those of brassinosteroids, flavonoids, and phenylpropanoids.
MetaMorph: formalization of domain-specific conceptual modeling methods—an evaluative case study, juxtaposition and empirical assessment
Authors: Döller Victoria , Karagiannis Dimitris , Utz Wilfrid 
Published: October 2022

AbstractModels have evolved from mere pictures supporting human understanding and communication to sophisticated knowledge structures processable by machines and establish value through their processing capabilities. This entails an inevitable need for computer-understandable modeling languages and causes formalization to be a crucial part in the lifecycle of engineering a modeling method. An appropriate formalism must be a means for providing a structural definition to enable a theoretical investigation of conceptual modeling languages and a unique, unambiguous way of specifying the syntax and semantics of an arbitrary modeling language. For this purpose, it must be generic and open to capturing any domain and any functionality. This paper provides a pervasive description of the formalism MetaMorph based on logic and model theory—an approach fulfilling the requirements above for modeling method engineering. The evaluation of the formalism is presented following three streams of work: First, two evaluative case studies illustrate the applicability of MetaMorph formalism concept by concept on the modeling language ProVis from the domain of stochastic education and the well-known Entity-Relationship language. ProVis as well as ER comprise only a few objects and relation types but with high interconnection and expressive power and are therefore considered interesting specimens for formalization. Second, a comprehensive juxtaposition of MetaMorph to three other formalization approaches based on different foundational theories is outlined concept by concept to underpin the formalism design. Third, an empirical evaluation has been performed, assessing the usability and adequacy of the formalism within a classroom assessment. The results allow for conclusions on the completeness, intuitiveness, and complexity as well as on interdependencies with engineers’ skills.