bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ubiquitin‐specific protease 28 deubiquitinates TCF7L2 to govern the action of the Wnt signaling pathway in hepatic carcinoma
Authors: Sun Xiao , Cai Mengjiao , Wu Lingzhi , Zhen Xinghua , Chen Yuetong , Peng Jin , Han Suxia , Zhang Pumin 
Published: July 2022

AbstractOverexpression of ubiquitin‐specific protease 28 (USP28) is found in hepatic carcinoma. It is unclear whether the deubiquitinase plays a role in hepatocarcinogenesis. Deregulation of the Wnt signaling pathway is frequently associated with liver cancer. Transcription factor 7‐like 2 (TCF7L2) is an important downstream transcription factor of the Wnt/β‐catenin signaling pathway, but the mechanisms by which TCF7L2 itself is regulated have not yet been revealed. Here, we report that USP28 promotes the activity of the Wnt signaling pathway through maintaining the stability of TCF7L2. We further show that FBXW7 is the E3 ubiquitin ligase for TCF7L2. By regulating the levels of TCF7L2, USP28 modulates the Wnt/β‐catenin signaling in liver cancer and USP28 depletion or inhibition by a small molecule inhibitor leads to a halt of growth in liver cancer cells. These results suggest that USP28 could be a potential therapeutic target for liver cancer.
Associations of socioeconomic and health factors with dental non‐attendance: A comparison of three cohorts of women
Authors: Wilson Louise Forsyth , Xu Zhiwei , Doust Jenny , Mishra Gita Devi , Dobson Annette Jane 
Published: July 2022

AbstractObjectivesMost studies on factors influencing dental attendance are cross‐sectional and focus on specific age groups. The associations between private ancillary health insurance, tobacco smoking, alcohol consumption and overweight/obesity with dental attendance were examined in three cohorts of Australian women of different ages using multiple waves of data over similar time periods.MethodsData from 10 233, 12 378 and 7892 women born in 1973–1978, 1946–1951 and 1921–1926 participating in the Australian Longitudinal Study on Women's Health were used. Poisson regression using generalized estimating equations was used to investigate factors associated with self‐report of not visiting the dentist in the 12 months before completing each wave.ResultsThe role of dental non‐attendance was higher in women without insurance (versus those with insurance) in all cohorts with adjusted rate ratios (RR) of 1.52 95% CI 1.48–1.57, RR 1.45 95% CI 1.41–1.49 and RR 1.32 95% CI 1.28–1.36 in the 1973–78, 1946–51 and 1921–26 cohorts respectively. Current smokers at any intensity (versus never smokers) had a higher risk of non‐attendance and the risk was strongest for women in the 1946–51 cohort who smoked ≥20 cigarettes/day (RR 1.35 95% CI 1.30–1.41). Compared with low‐risk drinkers, non‐drinkers were more likely to be non‐attenders, but only in the two older cohorts. Women who were overweight or obese (versus healthy weight) were more likely to be non‐attenders in all cohorts, with the risk of non‐attendance higher with increasing BMI.ConclusionsThis study emphasizes the continued need to address socioeconomic inequities in access to dental care, along with strategies to overcome barriers for those who are obese or smoke. In this study, barriers to access existed for women of all ages, indicating that interventions need to be appropriate across age groups.
Wide Gamut Moment‐based Constrained Spectral Uplifting
Authors: Tódová L. , Wilkie A. , Fascione L. 
Published: July 2022

AbstractSpectral rendering is increasingly used in appearance‐critical rendering workflows due to its ability to predict colour values under varying illuminants. However, directly modelling assets via input of spectral data is a tedious process: and if asset appearance is defined via artist‐created textures, these are drawn in colour space, i.e. RGB. Converting these RGB values to equivalent spectral representations is an ambiguous problem, for which robust techniques have been proposed only comparatively recently. However, other than the resulting RGB values matching under the illuminant the RGB space is defined for (usually D65), these uplifting techniques do not provide the user with further control over the resulting spectral shape. In a recent publication, we have proposed a method for constraining the spectral uplifting process so that for a finite number of input spectra that need to be preserved, it always yields the correct uplifted spectrum for the corresponding RGB value. We extend this previous work, which supported the sRGB gamut only, by describing a method that is able to constrain any spectrum from within the gamut of realisable reflectances. Due to constraints placed on the uplifting process, target RGB values that are in close proximity to one another uplift to spectra within the same metameric family, so that textures with colour variations can be meaningfully uplifted. Renderings uplifted via our method show minimal discrepancies when compared to the original objects.
An effective context‐focused hierarchical mechanism for task‐oriented dialogue response generation
Authors: Zhao Meng , Jiang Zejun , Wang Lifang , Li Ronghan , Lu Xinyu , Hu Zhongtian , Chen Daqing 
Published: July 2022

AbstractTask‐oriented dialogue system (TOD) is one kind of application of artificial intelligence (AI). The response generation module is a key component of TOD for replying to user's questions and concerns in sequential natural words. In the past few years, the works on response generation have attracted increasing research attention and have seen much progress. However, existing works ignore the fact that not each turn of dialogue history contributes to the dialogue response generation and give little consideration to the different weights of utterances in a dialogue history. In this article, we propose a hierarchical memory network mechanism with two steps to filter out unnecessary information of dialogue history. First, an utterance‐level memory network distributes various weights to each utterance (coarse‐grained). Second, a token‐level memory network assigns higher weights to keywords based on the former's output (fine‐grained). Furthermore, the output of the token‐level memory network will be employed to query the knowledge base (KB) to capture the dialogue‐related information. In the decoding stage, we take a gated‐mechanism to generate response word by word from dialogue history, vocabulary, or KB. Experiments show that the proposed model achieves superior results compared with state‐of‐the‐art models on several public datasets. Further analysis demonstrates the effectiveness of the proposed method and the robustness of the model in the case of an incomplete training set.
Melanomversorgung während eines Jahres Pandemie in Berlin: abnehmende Terminstornierungen trotz zunehmender Besorgnis über COVID‐19
Authors: Micek Aleksandra , Diehl Katharina , Teuscher Miriam , Schaarschmidt Marthe‐Lisa , Sasama Bianca , Ohletz Jan , Burbach Guido , Kiecker Felix , Hillen Uwe , Harth Wolfgang , Peitsch Wiebke K. 
Published: July 2022

ZusammenfassungHintergrund und ZieleDie COVID‐19‐Pandemie stellt für Krebspatienten eine große Herausforderung dar. Unser Ziel war es, ihren Einfluss auf die Behandlung und auf Arzttermine von Melanompatienten nach einem Jahr Pandemie zu untersuchen.Patienten und MethodikMelanompatienten, die im Vivantes Hauttumorzentrum in Berlin behandelt wurden, beantworteten eine postalische Umfrage zu Pandemie‐bedingten Änderungen ihrer Melanomversorgung. Einflussfaktoren auf Terminänderungen wurden mit deskriptiven Analysen und multivariater logistischer Regression untersucht. Daten nach einem Jahr Pandemie wurden mit Daten nach der ersten Welle verglichen.ErgebnisseVon den 366 Teilnehmern (57,7 % Männer; Durchschnittsalter 69,2 Jahre, Rücklaufquote: 36,1 %) berichteten 38 (10,1 %) über verschobene oder verpasste Arzttermine, meist auf eigenen Wunsch (71,1 %) aus Angst vor COVID‐19 (52,6 %). Eine aktuelle Therapie war mit einem geringeren Risiko, Termine zu verpassen, assoziiert (Odds Ratio [OR]: 0,194, p = 0,002), höheres Alter (OR: 1,037, p = 0,039), längere Krankheitsdauer (OR: 1,007, p = 0,028) und ein höherer Schulabschluss (OR: 2,263, p = 0,043) mit höherer Wahrscheinlichkeit. Von den 177 Patienten, die aktuell eine Therapie erhielten, erfuhren nur 1,7 % Pandemie‐bedingte Behandlungsänderungen. Die Besorgnis über COVID‐19 war nach einem Jahr Pandemie signifikant größer als nach der ersten Welle, die Zahl der verpassten Arzttermine jedoch niedriger.SchlussfolgerungenPandemie‐bedingte Änderungen waren in unserer Kohorte selten und nahmen trotz zunehmender Besorgnis mit der Zeit ab.
S1‐Leitlinie: Differenzialdiagnose akuter und chronischer Rötungen der Unterschenkel
Authors: Zidane Miriam , Jungkunz Hans‐Wilfried , Kahle Birgit , Miller Anya , Ochsendorf Falk , Sunderkötter Cord , Traidl‐Hoffmann Claudia , Wurpts Gerda , Nast Alexander 
Published: July 2022

ZusammenfassungAkute oder chronische Rötungen der Unterschenkel sind ein häufiger Vorstellungsgrund in Kliniken und Praxen und stellen oftmals eine differenzialdiagnostische Herausforderung dar. Ziel dieser Leitlinie ist es, Kriterien und Vorgehensweisen für die Differenzialdiagnose akuter oder chronischer, uni‐ oder bilateraler Rötungen der Unterschenkel festzulegen. Eine korrekte Diagnosestellung ist essenziell, um die adäquate Therapie auszuwählen und den nicht indizierten Einsatz von Antibiotika zu reduzieren. Von der Leitliniengruppe wurden die relevantesten Differenzialdiagnosen identifiziert: (1.) Erysipel, (2.) Stauungsdermatitis, (3.) hypererge Ictusreaktion, (4.) oberflächliche und tiefe Beinvenenthrombose, (5.) Gicht, (6.) chronisch allergisches Kontaktekzem und (7.) akutes toxisches beziehungsweise allergisches Kontaktekzem. Für diese sieben Diagnosen wurden Algorithmen beziehungsweise Diagnosepfade zum diagnostischen Vorgehen, die jeweils in Anamnese, klinische Untersuchung und apparative Diagnostik aufgegliedert sind, entwickelt. Darüber hinaus hat die Leitliniengruppe mindestens 40 weitere Differenzialdiagnosen gesammelt und spezifische Charakteristika zur differenzialdiagnostischen Abgrenzung tabellarisch gegenübergestellt.
Parasitoids affect plant responses through their host Pieris brassicae, but not for the benefit of their own performance
Authors: Cuny Maximilien A. C. , Bourne Mitchel E. , Poelman Erik H. 
Published: July 2022

Abstract
Upon parasitism, many parasitoids inject symbiotic viruses and venom into their host. Thereby, they modify the hosts physiology including its saliva composition and, in turn, plant perception of herbivory.
It has been hypothesised that parasitoids manipulate plant responses to increase their host performance and maximise their own fitness. However, it is still unclear whether parasitoids are under selective pressure to increase plant quality or whether indirect changes in plants due to parasitism are a by‐product of the physiological changes induced in their host.
We tested whether the parasitoids Hyposoter ebeninus and Cotesia glomerata manipulate induced plant responses through the host Pieris brassicae caterpillars to increase their own performance. During their entire lifespan, parasitised herbivores were fed with leaf material of Brassica oleracea plants that were left untreated or continuously exposed to feeding by either unparasitised, conspecific or heterospecific parasitised caterpillars. We measured the development time, weight, clutch size and mortality of parasitoids that emerged from caterpillars as proxy for their performance.
Both parasitoid species did not perform significantly better when their host was fed with leaves from plants continuously induced by a conspecific parasitoid relative to unparasitised caterpillars. However, parasitoid species asymmetrically affected each other's performance through plant‐mediated interactions.
Our results do not support the hypothesis of parasitoids manipulating plant responses for their own benefit, suggesting that indirect plant‐mediated interactions among parasitoids may be a by‐product of host manipulation. However, our work confirms the significance of parasitoid‐induced plant‐mediated interactions in insect communities that to date are still understudied.
Treatment horizon in multiple myeloma
Authors: Soekojo Cinnie Yentia , Chng Wee Joo 
Published: July 2022

AbstractObjectivesThis paper reviews current and emerging therapies for multiple myeloma (MM).MethodsNarrative review.ResultsMM is a complex, heterogenous condition, and in recent years there has been an expansion in the number and range of treatments. Several new treatment approaches, including enhanced monoclonal antibodies, antibody‐drug conjugates, bispecific T‐cell engagers, and chimeric antigen‐T‐cell therapy are under development.ConclusionsThe emergence of new treatments that aim to tackle MM‐associated immune dysfunction has led to improvements in overall survival.
The frequency and clinical significance of centromere enumeration probe 17 alterations in human epidermal growth factor receptor 2 immunohistochemistry‐equivocal invasive breast cancer
Authors: Katayama Ayaka , Starczynski Jane , Toss Michael S , Shaaban Abeer M , Provenzano Elena , Quinn Cecily M , Callagy Grace , Purdie Colin A , Millican‐Slater Rebecca , Purnell David , Chagla Leena , Oyama Tetsunari , Pinder Sarah E , Chan Steve , Ellis Ian , Lee Andrew H S , Rakha Emad A 
Published: July 2022

Background and aimsChromosome 17 alterations affect the assessment of HER2 gene amplification in breast cancer (BC), but its clinical significance remains unclear. This study aimed to identify the prevalence of centromere enumeration probe 17 (CEP17) alterations, and its correlation with response to neoadjuvant therapy (NAT) in BC patients with human epidermal growth factor receptor 2 (HER2) immunohistochemistry‐equivocal score.Methods and resultsA large BC cohort (n = 6049) with HER2 immunohistochemistry score 2+ and florescent in‐situ hybridisation (FISH) results was included to assess the prevalence of CEP17 alterations. Another cohort (n = 885) with available clinicopathological data was used to evaluate the effect of CEP17 in the setting of NAT. HER2‐amplified tumours with monosomy 17 (CEP17 copy number < 1.5 per nucleus), normal 17 (CEP17 1.5–< 3.0) and polysomy 17 (CEP17 ≥ 3.0) were observed in 16, 59 and 25%, respectively, compared with 3, 74 and 23%, respectively, in HER2‐non‐amplified tumours. There was no significant relationship between CEP17 alterations and pathological complete response (pCR) rate in both HER2‐amplified and HER2‐non‐amplified tumours. The independent predictors of pCR were oestrogen (ER) negativity in HER2‐amplified tumours [ER negative versus positive; odds ratio (OR) = 11.80; 95% confidence interval (CI) = 1.37–102.00; P = 0.02], and histological grade 3 in HER2 non‐amplified tumours (3 versus 1, 2; OR = 5.54; 95% CI = 1.61–19.00; P = 0.007).ConclusionThe impacts of CEP17 alterations are not as strong as those of HER2/CEP17 ratio and HER2 copy number. The hormonal receptors status and tumour histological grade are more useful to identify BC patients with a HER2 immunohistochemistry‐equivocal score who would benefit from NAT.
Synthesis of tubular silica fiber via all‐aqueous microfluidics for geopolymer regulation
Authors: Wu Hao , Ren Yukun , Jiang Tianyi , Chen Juzheng , Wu Wenlong , Lu Yang , Jiang Hongyuan 
Published: July 2022

AbstractLightweight hollow ceramic microfibers/microparticles hold promising prospects in numerous applications. To date, it remains a challenge to develop a fabrication strategy that well balances product quality and efficiency. In this article, an all‐aqueous microfluidic method was proposed to prepare tubular polymeric fiber as the preceramic template. The relevant dimensional parameters could be promptly regulated via simple flow rate control. This approach could serve as a general technical route to preparing different kinds of ceramics by switching the types of nanoparticles. Here, silica nanoparticles were introduced and the ceramic microfiber could be got via calcination. Afterward, the tubular silica microfiber was employed to synthesize geopolymer composite by mold casting. The chemically formed interfacial bonding between the silica microfiber and geopolymer matrix was confirmed by elemental analysis. The addition of 10% volume fraction silica microfiber could not only increase the flexural modulus of geopolymer composite by 3.5 times but also effectively inhibited crack propagation under thermal circumstances.
Spanish adaptation and validation of the Cultural Competence Assessment Tool (CCATool) for undergraduate nursing students
Authors: Vázquez‐Sánchez María Ángeles , Casals‐Vázquez Alicia , Sánchez‐Ojeda María Angustías , García‐Gámez Marina , Papadopoulos Irena , Casals Cristina 
Published: July 2022

AbstractAimTo analyse and validate a contextually adapted version of the Papadopoulos’ Cultural Competence Assessment Tool (CCATool) for Spanish undergraduate nursing students.BackgroundGlobalization has driven and intensified international migration. Thus, nurses must treat patients of many different cultural origins. Accordingly, both cultural competence and an appropriate tool with which to evaluate it are required.MethodsThe CCATool questionnaire was adapted for use in a Spanish context and was evaluated through a questionnaire completed by 262 undergraduate nursing students. Seven days later, the same students completed the questionnaire, without any intervention, and a subgroup of 144 students completed the questionnaire for a third time after taking a course in Transcultural Care. The reliability, sensitivity and stability of the questionnaire were assessed.ResultsThe reliability of the questionnaire obtained an adequate Cronbach's alpha of 0.81. Stability was assessed at seven days, using the intraclass correlation coefficient, which showed good/excellent results. Moreover, the questionnaire was able to detect the changes related to the nursing educative programme, thus highlighting a good sensitivity of the tool.ConclusionCultural competence is an essential element of nurses’ education, and instruction in this area should begin as soon as possible. In addition, an appropriate evaluation system is required. For this purpose, the present study describes and analyses a valid, reliable tool for use with undergraduate nursing students in Spain.Implications for nursing and health policyHealth and education policies must be sensitive to the ethnic and cultural differences of the patients who are cared for, and address the situations that cause difficulties in care. Hospitals and health centres must offer good care to patients from diverse cultures, so one of the necessary situations is the training and evaluation of the cultural competence of health professionals.
Financial development and economic growth in BRICS revisited: An application of cross‐sectional augmented ARDL
Authors: Selvasundaram K. , Sagathevan S. , Abdu Murtala 
Published: July 2022

AbstractThis study reassesses the relationship between financial development and economic growth using the datasets of BRICS countries. The MG‐ARDL and CD‐ARDL (MG) models are considered to account for both heterogeneity and cross‐sectional dependency. The overall results reveal a negative and insignificant effect of financial development on GDP from a MG‐ARDL linear model and a negative and significant relationship between financial development and economic growth from the linear CD‐ARDL (MG). However, when the square term of credit to the private sector is introduced, it is found that a positive and highly significant relationship exists between financial development and economic growth up to a point beyond which it turns negative and significant for both the MG‐ARDL and CD‐ARDL (MG) models. Based on the results, it is concluded that the excessive supply of private credit is harmful to the economy, thereby slowing its growth. Policy suggestions have also been discussed.
MicroRNAs as serum biomarkers in Becker muscular dystrophy
Authors: Gagliardi Delia , Rizzuti Mafalda , Brusa Roberta , Ripolone Michela , Zanotti Simona , Minuti Elisa , Parente Valeria , Dioni Laura , Cazzaniga Sara , Bettica Paolo , Bresolin Nereo , Comi Giacomo Pietro , Corti Stefania , Magri Francesca , Velardo Daniele 
Published: July 2022

AbstractBecker muscular dystrophy (BMD) is an X‐linked neuromuscular disorder due to mutation in the DMD gene, encoding dystrophin. Despite a wide clinical variability, BMD is characterized by progressive muscle degeneration and proximal muscle weakness. Interestingly, a dysregulated expression of muscle‐specific microRNAs (miRNAs), called myomirs, has been found in patients affected with muscular dystrophies, although few studies have been conducted in BMD. We analysed the serum expression levels of a subset of myomirs in a cohort of 29 ambulant individuals affected by BMD and further classified according to the degree of alterations at muscle biopsy and in 11 age‐matched healthy controls. We found a significant upregulation of serum miR‐1, miR‐133a, miR‐133b and miR‐206 in our cohort of BMD patients, supporting the role of these miRNAs in the pathophysiology of the disease, and we identified serum cut‐off levels discriminating patients from healthy controls, confiming the potential of circulating miRNAs as promising noninvasive biomarkers. Moreover, serum levels of miR‐133b were found to be associated with fibrosis at muscle biopsy and with patients' motor performances, suggesting that miR‐133b might be a useful prognostic marker for BMD patients. Taken together, our data showed that these serum myomirs may represent an effective tool that may support stratification of BMD patients, providing the opportunity of both monitoring disease progression and assessing the treatment efficacy in the context of clinical trials.
Stress signalling and STAT1 activation characterize the keratinocytic gene expression pattern in Hidradenitis suppurativa
Authors: Frings V.G. , Jopp L. , Srivastava M. , Presser D. , Goebeler M. , Schmidt M. 
Published: July 2022

AbstractBackgroundThe pathogenetic factors generating the innate immune signal necessary for T‐cell activation, initiation and chronification of Hidradenitis suppurativa (HS, also known as Acne inversa) are still poorly understood. Emerging evidence suggests that a defective keratinocyte function critically contributes to HS disease development and progression.ObjectivesTo elucidate the role of keratinocytes in HS lesion formation, we compared the transcriptomes of lesional and perilesional epidermis isolated from HS patients by RNA sequencing (RNA Seq).MethodsPairwise‐matched lesional and perilesional HS skin samples of five different donors were obtained and epidermal keratinocytes freshly isolated and processed for RNA extraction and RNA seq. Lesionally regulated genes were analysed by large‐scale promoter analysis and functional annotation clustering to identify epidermally overrepresented transcription factor binding sites and functionally related gene groups. Results were experimentally validated with independent epidermal isolates of patient‐matched lesional and perilesional HS skin employing qRT‐PCR, cell culture, immunoblot and immunostaining.ResultsWe show that HS is characterized by a strong epidermal stress state evident by a significant overrepresentation of an AP‐1‐driven gene signature and a substantial activation of the stress‐activated cJun N‐terminal kinase (JNK) pathway in lesional epidermis. Additionally, our data reveal a strong induction of STAT1 activation in lesional HS epidermis that likely results from IFNγ production and triggered expression of key inflammatory genes coordinating innate immune activation and the adaptive T‐cell response in HS.ConclusionsOur data implicate a key role of stress signalling and JAK/STAT1 activation in disease progression of HS and suggest interference with JAK/STAT1 signalling as a potentially promising therapeutic approach for HS.