bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular and immunohistochemical characterisation of mesothelioma of the tunica vaginalis*
Authors: Anderson William J , Sholl Lynette M , Fletcher Christopher D M , Schulte Stephanie , Wang Li Juan , Maclean Fiona M , Hirsch Michelle S 
Published: April 2022

AimsMalignant mesothelioma (MM) of the tunica vaginalis (TV) is a rare and aggressive tumour, and the molecular features and staining profile with contemporary immunohistochemical (IHC) biomarkers are largely unexplored. We characterise the clinicopathological, molecular and IHC features of MM (n = 13) and mesothelial neoplasms of uncertain malignant potential (MUMP) (n = 4).Methods and resultsTargeted next‐generation sequencing was performed on seven MMs and two MUMPs. IHC was performed for methylthioadenosine phosphorylase (MTAP), BRCA1‐associated protein 1 (BAP1) and SRY‐box transcription factor 6 (SOX6). Thirteen adenomatoid tumours were also assessed with SOX6. MM were epithelioid (seven of 13) or biphasic (six of 13). In MM, NF2 (five of seven; 71%), CDKN2A (three of seven; 43%) and BAP1 (two of seven; 29%) were most frequently altered. Non‐recurrent driver events were identified in PTCH1 and TSC1. In contrast, none of these alterations were identified in MUMPs; however, one MUMP harboured a TRAF7 missense mutation. By IHC, loss of MTAP (two of 12; 17%) and BAP1 (two of nine; 22%) was infrequent in MM, whereas both were retained in the MUMPs. SOX6 was positive in nine of 11 (82%) MMs and negative in all MUMPs and adenomatoid tumours.ConclusionsTesticular MM exhibit a similar mutational profile to those of the pleura/peritoneum; however, alterations in CDKN2A and BAP1 are less common. These findings suggest that although MTAP and BAP1 IHC are specific for MM, their sensitivity in testicular MMs appears lower. In addition, rare tumours may harbour targetable alterations in driver genes (PTCH1 and TSC1) that are unusual in MMs at other anatomical sites. SOX6 is sensitive for MM; accordingly, the presence of SOX6 expression argues against a benign neoplastic process.
Three decades of halal food scholarly publications: A PubMed bibliometric network analysis
Authors: Mostafa Mohamed M. 
Published: April 2022

AbstractHalal food research has witnessed a distinct proliferation during the past decade. In this article, we examine the intellectual structure of the field based on 302 PubMed documents written by 686 authors representing 45 nations and spanning 30 years (1990–2019). The study applies bibliometric network techniques to explore the halal food impactful authors, influential journals, collaboration networks and emerging trends. Social network analysis (SNA) techniques are also used to unearth and mine the intellectual structure of the field. Additionally, we use keyword co‐occurrence techniques to scrutinize the field's major schools of thought. Results show that the most impactful PubMed outlets publishing halal food research include Food Chemistry, Meat Science, and the Journal of the Science of Food and Agriculture. Results also show that the authors' collaboration network in halal food is sparse. Furthermore, results reveal a global “North–South” schism between nations within the domain. Finally, the multiple correspondence analysis (MCA) applied to obtain the halal food research conceptual map and its intellectual structure reflects the depth and breadth of the field.
Characterisation of hydrogels and aerogels as carriers for sea buckthorn pomace extract
Authors: Švermickaitė Greta , Eisinaitė Viktorija , Vinauskienė Rimantė , Jasutienė Ina , Leskauskaitė Daiva 
Published: April 2022

SummaryIn this study, aerogels were prepared from kognac glucomannan (KG) or whey proteins loaded with bioactive sea buckthorn pomace extract. KG was diacetylated with Na2CO3 (0.1; 0.2; 0.3; 0.4 m) resulting hydrogel formation that were further freeze‐dried to obtain an aerogel structure. Whey protein aerogels were prepared by removing pore fluid from alcogels using supercritical CO2 drying. Produced aerogels evaluated for microstructure, porosity, specific surface area, absorption capacity, encapsulation efficiency and antioxidant capacity of the extract. It was found that higher concentration of alkali induced higher hardness, resilience and elastic modulus values. It was also obtained that pores in the konjac glucomannan aerogels were irregular in shape and a decrease in total pore volume (0.026 to 0.019 cc/g) and surface area (12.39 to 11.40 m2/g) after increasing the carbonate concentration was observed. These aerogels were found to have better encapsulation efficiency properties for sea buckthorn pomace extract (17 to 20%) in comparison to whey protein aerogels (0.05 to 0.36%). Overall, the KG aerogels show potential for applications in the food industry as a carrier of bioactive sea buckthorn pomace extract, while whey proteins must be used in combination with other biopolymers to enhance their bioactive compound loading capacity.
Effect of vacuum packaging on shelf‐life extension of cooked and peeled harpiosquillid mantis shrimp (Harpiosquilla raphidea) during refrigerated storage
Authors: Temdee Wattana , Singh Avtar , Zhang Bin , Benjakul Soottawat 
Published: April 2022

SummaryEffects of vacuum packaging (VP) on quality changes of cooked and peeled harpiosquillid mantis shrimp (HMS) during storage at 4 °C of 15 days were investigated. VP inhibited bacterial growth as ascertained by the lower rate of increases in total viable and psychrotrophic bacteria counts as well as other pathogenic and spoilage bacteria counts. VP samples had lower total volatile base and trimethylamine contents as compared to the sample packed in air (AP). Clostridium perfringens was undetectable in both samples. During storage, VP samples possessed lower pH than AP counterpart. Exudate and TCA‐soluble peptide (TSP) contents of sample increased during the storage, regardless of packaging atmospheres. Fatty acid (FA) content, especially PUFA and MUFA, was decreased after 9 and 15 days of storage for AP and VP samples, respectively. The cooked and peeled HMS contained 32 volatile organic compounds, consisting of several aldehydes and alcohols. Carnobacterium and Pseudomonas were mainly involved in spoilage in samples as confirmed by next generation sequencing.
Lactobacillus plantarum ZLC‐18 fermentation improve tyrosinase inhibition activity and antioxidant capacity in soybean hulls
Authors: Xu Hanxue , Sun Jinwei , Zhao Zifu , Ma Xinkai , Li Chun , Liu Libo , Zhang Guofang 
Published: April 2022

SummarySoybean hulls, the main byproduct in soybean processing, have many biological activities. However, the value of this byproduct is still far from being fully exploited. In this study, we investigated the anti‐tyrosinase and antioxidant capacities in soybean hulls fermented by Lactobacillus plantarum ZLC‐18 (L. plantarum ZLC‐18). We found that L. plantarum ZLC‐18 fermentation could markedly improve the anti‐tyrosinase and antioxidant activities of soybean hulls. The anti‐tyrosinase and antioxidant activities were positively correlated with the total phenolic and flavonoid contents. UPLC–MS analysis suggested that phenolic compounds (daidzin, genistin, vanillic acid and so on) were increased in soybean hulls after fermentation, and some of these compounds were shown to have anti‐tyrosinase and antioxidant activities. Our study demonstrates that fermentation is an efficient strategy to enhance the bioactive function of soybean hulls. Moreover, this study provides evidence that soybean hulls can be used as a kind of functional food ingredient, thereby improving their economic benefits.
Effects of different polarity of onion skin extracts on antioxidative properties and non‐volatile profiles
Authors: Hong JiHee , Lee YoonHee , Kim Mi‐Ja , Lee JaeHwan 
Published: April 2022

SummaryOnion skins are agricultural by‐products that contain high levels of antioxidants, including quercetin and protocatechuic acid. The solubility of extracts can affect their antioxidant capacity in food oil matrices. The antioxidative properties of onion skin extracts with different polarity were compared and the chemical profiles of the extracts were identified by GC‐MS. Highly lipophilic, moderately hydrophilic and highly hydrophilic onion skin extracts (HLE, MHE and HHE, respectively) were prepared and their antioxidant properties were tested using in vitro assays and bulk oil or oil‐in‐water (O/W) emulsions. The most abundant phenolic compounds in the onion skin extracts were quercetin and protocatechuic acid. The lipophilicity levels of HLE, MHE and HHE were 0.674, 0.394 and −1.225, respectively. HLE showed higher antioxidant capacity in bulk oil and O/W emulsion matrices compared to MHE and HHE. The antioxidant capacity of HLE was higher in the O/W emulsion than in the bulk oil system. Therefore, highly lipophilic onion skin extracts can be used as effective natural antioxidants in oil matrices, especially O/W emulsions.
Mindfulness: Unpacking its three shades and illuminating integrative ways to understand the construct
Authors: Daniel Carole , Walsh Isabelle , Mesmer‐Magnus Jessica 
Published: April 2022

AbstractOver time mindfulness research and practice has taken on diverse basic assumptions and theoretical traditions, and the pseudo‐scientific use of the term has become more prevalent. Given the ubiquitousness of both personal and professional applications of mindfulness, the need for a thorough understanding of its theoretical cornerstones is necessary. In this review, we use bibliometric techniques to uncover the field's intellectual roots (Study 1), and document bibliographic coupling analysis to illuminate current research avenues across management disciplines (Study 2). Our bibliometric process covers 48 references for co‐citation and 238 articles for bibliographic coupling analyses, respectively, published between 2012 and 2020. Co‐citation analysis reveals a shift of focus from the past two historical mindfulness schools of thought (Eastern and Western) to a novel intellectual structure of the mindfulness field articulated around three distinct yet overlapping research streams. We propose integrative ways to advance mindfulness research by unpacking mindfulness processes, dimensions and development, arguing that the integration of these three main foci is necessary to advance understanding of mindfulness. Bibliometric coupling analysis identifies eight management‐related mindfulness research themes. We discuss the extent to which these eight themes have comparably explored the three foci (mindfulness processes, dimensions and development) highlighted in our model. Lastly, we use our theory‐driven review to draw on under‐developed areas of research, identifying profitable directions for future research on mindfulness in the workplace and beyond.
The Orders of Vocation: A Brunnerian Proposal
Authors: Holleyman Taylor D. 
Published: April 2022

AbstractThis article draws on the idea of the ‘orders of creation’ as developed in Emil Brunner’s The Divine Imperative (1932) and shows that Brunner’s understanding of the orders provides a fruitful theological foundation for conceptualizing Christian vocation and for framing the process of discernment therein. However, the concept of orders of creation is a mistrusted doctrine with problematic historical baggage. A few attempts have been made to rehabilitate the concept of the orders, but a successful revival requires a more thorough reimagining of the doctrine than has been previously attempted. Examining Christian vocation within the framework of the orders of creation, I undertake to reimagine the doctrine of orders as orders of vocation, supplying a definition of vocation as the unifying principle of those tasks which emerge where the will of God intersects with one’s familial, economic, political, cultural and ecclesial responsibilities. The orders of vocation serve as a heuristic device that relativizes vocation in light of the particularities of concrete life. All activity within the orders of vocation is inevitably moral activity. Also, the orders of vocation, as opposed to orders of creation, emphasize the perennial necessity of reformation within the spheres of communal life.
Individuation of agents based on psychological properties in 10 month‐old infants
Authors: Bródy Gábor , Oláh Katalin , Király Ildikó , Biro Szilvia 
Published: April 2022

AbstractWhat makes agents fundamentally different from each other from the viewpoint of a 10‐month‐old infant? While infants at this age can already individuate human‐like objects from non‐humanlike ones and self‐propelled agents from inert objects, little is known of when and how they start individuating within the domain of agents. What is clear from previous studies is that differences in surface and dynamic features are not sufficient. We hypothesized that mental properties—in this case the agents' preferences—can serve as an individuating property. In our study, we familiarized infants with two animated agents who had different preferences. The agents sequentially and repeatedly emerged from behind an occluder, and then each agent approached one of two target objects before returning behind the occluder. After familiarization, the occluder was lifted, revealing either one agent or two agents. While infants successfully individuated the agents in the preference‐demonstration condition, they failed to do so in the exposure‐only condition in which perceptually similar surface and dynamic features of the agents were presented but without indicating preferences. Our study thus provides evidence that mental properties can help individuate agents, grounding the claim that infants understand agents as mental entities at their core.
Alleviating psychological symptoms in nurses during disease outbreaks: An integrative review
Authors: Hawsawi Samah 
Published: April 2022

AbstractAimTo explore interventions and coping strategies used to treat the psychological symptoms associated with compassion fatigue among nurses.BackgroundThe rapid transmission of infectious diseases (e.g., COVID‐19) has put nurses, around the world, at high risk of developing profound psychological health issues due to compassion fatigue. If unrelieved, compassion fatigue can lead to catastrophic psychological symptoms such as depression, stress, anxiety, and insomnia, negatively impacting patient care. This necessitates interventions to prevent or mitigate the psychological symptoms of compassion fatigue.MethodFollowing Whittemore and Knafl's integrative review method, the literature search comprised three databases: CINAHL, MEDLINE‐OVID, and Scopus.ResultsThe 11 included studies were categorized into four themes: (1) using relaxation strategies, (2) neutralizing emotional trauma, (3) enhancing nurses’ preparedness for confronting disasters, and (4) educating nurses about coping strategies to manage their psychological issues.ConclusionResearchers studied several coping strategies and interventions. There is a need for policymakers' support and hospital‐level interventions. Early interventions may prevent or relieve psychological issues.ImplicationsThe findings have implications for hospital leaders around the world to initiate interventions that teach nurses strategies to cope with stressful events. Future researchers might consider long‐term supports and multiple interventions that target several leading causes of psychological symptoms among nurses before, during, and after high‐stress situations. Policymakers around the world could use the findings to initiate policies to facilitate nurses' access to needed resources, hence protecting their mental health and increasing the quality of patient care.
Inequalities in the disruption of paid work during the Covid‐19 pandemic: A world systems analysis of core, semi‐periphery, and periphery states
Authors: Valizade Danat , Ali Manhal , Stuart Mark 
Published: April 2022

AbstractThis article reveals the extent of international inequalities in the immediate impact of the COVID‐19 pandemic on participation in paid work. Drawing on World Systems Theory (WST) and a novel quasi‐experimental analysis of nationally representative household panel surveys across 20 countries, the study finds a much sharper increase in the likelihood of dropping out of paid work in semi‐periphery and periphery states relative to core states. We establish a causal link between such international disparities and the early trajectories of state interventions in the labor market. Further analysis demonstrates that within all three world systems delayed, less stringent interventions in the labor market were enabled by right‐wing populism but mitigated by the strength of active labor market policies and collective bargaining.
Citrulline protects human retinal pigment epithelium from hydrogen peroxide and iron/ascorbate induced damages
Authors: Hassel Chervin , Couchet Morgane , Jacquemot Nathalie , Blavignac Christelle , Loï Cécile , Moinard Christophe , Cia David 
Published: April 2022

AbstractOxidative stress plays an important role in the ageing of the retina and in the pathogenesis of retinal diseases such as age‐related macular degeneration (ARMD). Hydrogen peroxide is a reactive oxygen species generated by the photo‐excited lipofuscin that accumulates during ageing in the retinal pigment epithelium (RPE), and the age‐related accumulation of lipofuscin is associated with ARMD. Iron also accumulates with age in the RPE that may contribute to ARMD as an important source of oxidative stress. The aim of this work was to investigate the effects of L‐Citrulline (CIT), a naturally occurring amino acid with known antioxidant properties, on oxidative stressed cultured RPE cells. Human RPE (ARPE‐19) cells were exposed to hydrogen peroxide (H2O2) or iron/ascorbate (I/A) for 4 h, either in the presence of CIT or after 24 h of pretreatment. Here, we show that supplementation with CIT protects ARPE‐19 cells against H2O2and I/A. CIT improves cell metabolic activity, decreases ROS production, limits lipid peroxidation, reduces cell death and attenuates IL‐8 secretion. Our study evidences that CIT is able to protect human RPE cells from oxidative damage and suggests potential protective effect for the treatment of retinal diseases associated with oxidative stress.
Determinants of costs and benefits in atopic dermatitis routine care in Germany
Authors: Mohr N. , Augustin M. , Zeervi L. , Bieber T. , Werfel T. , Wollenberg A. , Langenbruch A. 
Published: April 2022

AbstractBackground and objectivesThe economic burden of atopic dermatitis (AD) is of particular interest. The present study aims to analyse the association of disease‐related characteristics, annual costs and treatment benefits in AD.MethodsBetween August 2017 and June 2019, a cross‐sectional observational study in patients with AD was conducted in Germany. Cost‐of‐illness data were assessed from the societal perspective. Disease characteristics included severity, time since diagnosis and therapy, as well as atopic comorbidity and the implementation of prevention measures. Subgroup analyses of the total costs were conducted for these characteristics. A linear regression model was applied to analyse the impact of disease characteristics on the costs. Furthermore, associations of biologic treatment with outcome parameters were analysed.ResultsA total of 1291 patients from 111 centres were included in the analyses. The total costs amounted on average to € 3660 ± € 6428 per patient and year. Higher costs were shown in various patient groups, for example, in patients using biologics (€ 20 983 vs. € 2470). In a regression analysis, gender, education and the number of implemented prevention measures were identified as significant predictors of costs. Patients treated with biologics showed consistently better outcome parameters and were more often satisfied with their treatment.ConclusionsGender, education and implemented prevention measures are significant cost determinants in AD. The results confirm that treatment with biologics is the main cost driver in AD. However, incremental patient‐relevant benefits of high‐priced therapy are reflected by the significantly better clinical outcomes in the group treated with biologics.
First discovery of Arsenophonus infection in spiders, predators of insect pests
Authors: Jiang Hanqi , Ding Yu , Zhao Dongxiao , Liu Xiangdong , Guo Huifang 
Published: April 2022

AbstractInfection of insect pests and their parasitoids with the facultative endosymbiont Arsenophonus has been well studied, whereas infection of insect pest predators with this symbiont has not been reported. Here, we studied this symbiont in the spider Pardosa pseudoannulata, an important predator of rice planthoppers, collected from rice paddies in 8 geographical regions in China. Diagnostic PCR showed that Arsenophonus was present in 4 of the 8 sampled populations of the spider. In these 4 populations infected with Arsenophonus, the infection incidence was between 2.1% and 16.7% and significantly differed between the Li Shui (LS) population and the other three populations. It also showed that Arsenophonus could coexist with Wolbachia in 2 populations of P. pseudoannulata, and Arsenophonus populations from different geographical regions exhibited low genetic differentiation.
Brown marmorated stink bug (Halyomorpha halys) feeding damage determines early drop in olive crops
Authors: Zapponi Livia , Morten Michele , Chiesa Serena Giorgia , Angeli Gino , Borri Giacomo , Mazzoni Valerio , Sofia Monica , Anfora Gianfranco 
Published: April 2022

AbstractThe brown marmorated stink bug (BMSB), Halyomorpha halys Stål, is an invasive species and a polyphagous pest. BMSB feeding activity was suspected to be responsible for olive damage. To evaluate the effect of feeding damage from adults and nymphs of BMSB, 30 rearing sleeves were positioned in an olive grove, at an early stage of drupe development. The individuals were kept in the rearing sleeves for 48 h, and the number of olives in each sleeve was checked weekly, visually assessing signs of damage and measuring their volume. After the 48‐hr exposure, the number of early dropped olives was significantly higher for rearing sleeves containing BMSB adults and nymphs compared with control, with visible signs of damage. The volume of olives still attached was significantly lower for rearing sleeves with adults. These results provide key evidence on BMSB damage in developing olives. If the numbers of BMSB keep increasing in Mediterranean regions (where most of the olive production occurs), actions should be taken to prevent economic losses.
Overlooked lacewings in biological control: The brown lacewing Micromus angulatus and the green lacewing Chrysopa formosa suppress aphid populations in pepper
Authors: Ntalia Paraskevi , Broufas George D. , Wäckers Felix , Pekas Apostolos , Pappas Maria L. 
Published: April 2022

AbstractLacewings are important natural enemies of soft‐bodied arthropods. Chrysopidae and Hemerobiidae in particular include promising biological control agents of key agricultural pests. Here, we evaluated the efficacy of larvae and adults of the brown lacewing Micromus angulatus and the green lacewing Chrysopa formosa in controlling the green peach aphid Myzus persicae under laboratory conditions. We found that the release of the first instar larvae of both species at the rate of 2 or 10 individuals per pepper plant was effective in reducing the populations of M. persicae, irrespectively of the initial pest infestation pressure, i.e., 10 or 20 aphids per plant. The brown lacewing larvae at the highest release rate managed to completely eliminate the aphids from the pepper plants within two weeks following release. Adult lacewings of both species released at a rate of one to two females per plant were also effective in drastically reducing of M. persicae populations. Our results highlight the potential of these two widespread but overlooked lacewing species for use in biological pest control.