bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunotherapeutic Value of MAP1LC3C and Its Candidate FDA-Approved Drugs Identified by Pan-Cancer Analysis, Virtual Screening and Sensitivity Analysis
Authors: Zhang Xudong , Li Kunhang , Zhong Shiyu , Liu Shengyu , Liu Tao , Li Lishuai , Han Shuo , Zhai Qingqing , Bao Nan , Shi Xin , Bao Yijun 
Published: March 2022

Background: The autophagy pathway within the tumour microenvironment can be regulated to inhibit or promote tumour development. In the fight against tumour growth, immunotherapy induces an anti-tumour immune response, whereas autophagy modulates this immune response. A key protein in the autophagy pathway, microtubule-associated protein 1 light chain 3 (MAP1LC3), has recently become a hotspot for tumour research. As a relatively novel member, the function of MAP1LC3C in tumours still need to be investigated. Therefore, the goal of this study was to look into the possible link between MAP1LC3C and immunotherapy for 33 kinds of human malignancies by using pan-cancer analysis.Methods: High-throughput sequencing data from The Cancer Genome Atlas, Genotype-Tissue Expression Project and Cancer Cell Line Encyclopedia databases, combined with clinical data, were used to analyze the expression of MAP1LC3C in 33 types of cancer, as well as patient prognosis and neoplasm staging. Activity scores were calculated using ssGSEA to assess the MAP1LC3C activity in pan-cancer. Associations between MAP1LC3C and the tumour microenvironment, including immune cell infiltration and immunomodulators, were analyzed. Moreover, tumour tissue ImmuneScores and StromalScores were analyzed using the ESTIMATE algorithm. Additionally, associations between MAP1LC3C and tumour mutational burden/microsatellite instability, were investigated. Finally, based on the expression and structure of MAP1LC3C, the United States Food and Drug Administration (FDA)-approved drugs, were screened by virtual screening, molecular docking and NCI-60 drug sensitivity analysis.Results: Our study found that MAP1LC3C was differentially expressed in tumour and normal tissues in 23 of 33 human cancer types, among which MAP1LC3C had prognostic effects in 12 cancer types, and MAP1LC3C expression was significantly correlated with tumour stage in four cancer types. In addition, MAP1LC3C activity in 14 cancer types was consistent with changes in transcription levels. Moreover, MAP1LC3C strongly correlated with immune infiltration, immune modulators and immune markers. Finally, a number of FDA-approved drugs were identified via virtual screening and drug sensitivity analysis.Conclusion: Our study investigated the prognostic and immunotherapeutic value of MAP1LC3C in 33 types of cancer, and several FDA-approved drugs were identified to be highly related to MAP1LC3C and can be potential cancer therapeutic candidates.
Time Resolution Studies of Thallium Based Cherenkov Semiconductors
Authors: Terragni Giulia , Pizzichemi Marco , Roncali Emilie , Cherry Simon R. , Glodo Jaroslaw , Shah Kanai , Ariño-Estrada Gerard , Auffray Etiennette , Ghezzi Alessio , Kratochwil Nicolaus 
Published: March 2022

In the context of improving the detector performance of time-of-flight positron emission tomography (TOF-PET), the combination of charge induction readout and prompt Cherenkov photon production in semiconductor materials can lead to an outstanding detector performance in energy, timing, and spatial resolution. Energy resolutions as good as 1.2% at 662 keV and 5% at 122 keV are reported for pixel thallium bromide (TlBr) detectors. The high refractive index of Tl-based materials, between 2.3 and 2.6, leads to a high Cherenkov photon generation yield but can also challenge photon extraction, potentially affecting the time performance. In this work, the timing properties of TlBr and thallium chloride (TlCl) crystals of different geometries are measured using an optimized test setup with high-frequency readout electronics. A coincidence time resolution (CTR) value of 167 ± 6 ps FWHM is achieved using a 3 × 3 × 3 mm3black-painted TlBr crystal. In order to assess potential improvements, a Geant4-based simulation tool kit is developed and validated against experimental measurements. The simulation tool kit is used to predict the contributions limiting the time resolution regarding the crystal and photodetector properties, highlighting the potential of such materials. Finally, paths to further improve the detector performance in TOF-PET are discussed.
Gray Matter Alterations in Pediatric Schizophrenia and Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis of Voxel-Based Morphometry Studies
Authors: Liu Jingran , Wen Fang , Yan Junjuan , Yu Liping , Wang Fang , Wang Duo , Zhang Jishui , Yan Chunmei , Chu Jiahui , Li Yanlin , Li Ying , Cui Yonghua 
Published: March 2022

ObjectiveThe aim of this study is comparing gray matter alterations in SCZ pediatric patients with those suffering from obsessive-compulsive disorder (OCD) based on a systematic review and an activation likelihood estimation (ALE) meta-analysis.MethodsA systematic literature search was performed in PubMed, Elsevier, and China National Knowledge Infrastructure (CNKI). A systematic review and an ALE meta-analysis were performed to quantitatively examine brain gray matter alterations.ResultsChildren and adolescents with schizophrenia had decreased gray matter volume (GMV) mainly in the prefrontal cortex (PFC), temporal cortex (such as the middle temporal gyrus and transverse temporal gyrus), and insula, while children and adolescents with OCD mainly had increased GMV in the PFC and the striatum (including the lentiform nucleus and caudate nucleus), and decreased GMV in the parietal cortex.ConclusionsOur results suggest that gray matter abnormalities in the PFC may indicate homogeneity between the two diseases. In children and adolescents, structural alterations in schizophrenia mainly involve the fronto-temporal and cortico-insula circuits, whereas those in OCD mainly involve the prefrontal-parietal and the prefrontal-striatal circuits.
Intra-rater Kappa Accuracy of Prototype and ICD-10 Operational Criteria-Based Diagnoses for Mental Disorders: A Brief Report of a Cross-Sectional Study in an Outpatient Setting
Authors: Rocha Neto Helio G. , Sinem Tomas Boldrini , Koiller Luisa Mendez , Pereira Amanda Machado , de Souza Gomes Bianca Marques , Veloso Filho Carlos Linhares , Cavalcanti Maria T. , Telles-Correia Diogo 
Published: March 2022

Background and ObjectivesThe use of “operational criteria” is a solution for low reliability, contrasting with a prototypical classification that is used in clinics. We aim to measure the reliability of prototypical and ICD-10 diagnoses.MethodsThis is a retrospective study, with a convenience sample of subjects treated in a university clinic. Residents reviewed their diagnosis using ICD-10 criteria, and Cohen's kappa statistic was performed on operational and prototype diagnoses.ResultsThree out of 30 residents participated, reviewing 146 subjects under their care. Diagnoses were grouped in eight classes: organic (diagnoses from F00 to F09), substance disorders (F10–F19), schizophrenia spectrum disorders (F20–F29), bipolar affective disorder (F30, F31, F34.0, F38.1), depression (F32, F33), anxiety-related disorders (F40–F49), personality disorders (F60–F69), and neurodevelopmental disorders (F70–F99). Overall, agreement was high [K = 0.77, 95% confidence interval (CI) = 0.69–0.85], with a lower agreement related to personality disorders (K = 0.58, 95% CI = 0.38–0.76) and higher with schizophrenia spectrum disorders (K = 0.91, 95% CI = 0.82–0.99).DiscussionUse of ICD-10 criteria did not significantly increase the number of diagnoses. It changed few diagnoses, implying that operational criteria were irrelevant to clinical opinion. This suggests that reliability among interviewers is more related to information gathering than diagnostic definitions. Also, it suggests an incorporation of diagnostic criteria according to training, which then became part of the clinician's prototypes. Residents should be trained in the use of diagnostic categories, but presence/absence checking is not needed to achieve operational compatible diagnoses.
Suicidality and Quality of Life in Treatment-Resistant Depression Patients in Latin America: Secondary Interim Analysis of the TRAL Study
Authors: Corral Ricardo , Alessandria Hernan , Agudelo Baena Lina María , Ferro Eugenio , Duque Xochitl , Quarantini Lucas , Caldieraro Marco Antonio , Cabrera Patricia , Kanevsky Gabriela 
Published: March 2022

BackgroundA large proportion of patients with major depressive disorder (MDD) have treatment-resistant depression (TRD). The TRAL study examines the impact of TRD on suicidality and health-related quality of life (HRQoL) among MDD patients in 4 Latin American countries.MethodsIn this multicenter, prospective, observational study, MDD patients were recruited from 33 sites in Mexico, Colombia, Brazil, and Argentina. Patients were assessed for TRD, defined as failure to respond to ≥2 antidepressant medications of adequate dose and duration. Other assessments included current disease status, Mini International Neuropsychiatric Interview (MINI), Columbia-Suicide Severity Rating Scale (C-SSRS), 5 Level EQ-5D (EQ-5D-5L), Patient Health Questionnaire-9 (PHQ-9), and Sheehan Disability Scale (SDS).Results1,475 MDD patients were included in the analysis (mean age, 45.6 years; 78% women), and 429 met criteria for TRD. Thoughts of suicide and suicide attempts were more common among TRD patients (38.7%) compared with non-TRD patients (24.9%; P &lt; 0.0001), according to the current disease status questionnaire. The C-SSRS showed that lifetime suicidal behavior was significantly more common among TRD patients than non-TRD patients (13.8 vs. 10.0%; P = 0.0384). Compared with non-TRD patients, TRD patients showed significantly greater adverse impacts on QoL (EQ-5D-5L), more severe depression (PHQ-9), and greater functional impairment (SDS).ConclusionTRD patients in clinical sites from Mexico, Colombia, Brazil, and Argentina were more likely to experience suicidality and negative effects on HRQoL than non-TRD patients.
Gender-Specific Related Factors for Suicidal Ideation During COVID-19 Pandemic Lockdown Among 5,175 Chinese Adolescents
Authors: Zhu Jin , Li Baohua , Hao Fengcheng , Luo Linlin , Yue Song , Zhai Jinguo , Chen Min , Liu Yan , Liu Debiao , Wang JianLi 
Published: March 2022

BackgroundSuicide was an urgent issue during the pandemic period in adolescents. However, few studies were focused on suicide during the coronavirus disease 2019 (COVID-19) pandemic lockdown.MethodsAn online survey was conducted among 5,175 Chinese adolescents from June 9th to 29th in 2020 to investigate the prevalence of suicidal ideation (SI) during COVID-19 pandemic lockdown. A gender-specific stepwise logistic regression model was used. All analyses were performed with STATA 15.0.ResultsAbout 3% of the participants had reported having SI during the COVID-19 pandemic lockdown period. The prevalence of female SI (3.64%, 95% CI: 2.97–4.45%) was higher than that of males (2.39%, 95% CI: 1.88–3.05%) (χ2 = 6.87, p = 0.009). Quarreling with parents [odds ratio (OR) = 9.73, 95% CI: 5.38–17.59], insomnia (OR = 5.28, 95% CI: 2.81–9.93), previous suicide attempt history (OR = 3.68, 95% CI: 1.69–8.03), previous SI history (OR = 2.81, 95% CI: 1.30–6.06), and feeling depressed during pandemic lockdown (OR = 2.26, 95% CI: 1.22–4.18) were positively associated with the males' SI. However, having emptiness inside (OR = 4.39, 95% CI: 2.19–8.79), quarreling with parents (OR = 3.72, 95% CI: 2.16–6.41), insomnia (OR = 3.28, 95% CI: 1.85–5.80), feeling anxious (OR = 2.62, 95% CI: 1.46–4.70), and longing for father's emotional warmth (OR = 0.38, 0.20–0.72) were associated mostly with females' SI.ConclusionsFemale adolescents, who felt emptiness from their families and their fathers' emotional warmth, were at much higher risk of having SI during COVID-19 lockdown. We must specify a suicide prevention policy and interventions for adolescents in the pandemic crisis based on gender gaps.
Spontaneous Ventilation Video-Assisted Thoracoscopic Surgery for Non-small-cell Lung Cancer Patients With Poor Lung Function: Short- and Long-Term Outcomes
Authors: Wang Runchen , Wang Qixia , Jiang Shunjun , Chen Chao , Zheng Jianqi , Liu Hui , Liang Xueqing , Chen Zhuxing , Wang Haixuan , Guo Zhuoxuan , Liang Wenhua , He Jianxing , Liang Hengrui , Wang Wei 
Published: March 2022

ObjectiveThe goal of this study was to explore the feasibility and safety of spontaneous ventilation video-assisted thoracoscopic surgery (SV-VATS) for non-small-cell lung cancer (NSCLC) patients with poor lung function.MethodsNSCLC patients with poor lung function who underwent SV-VATS or mechanical ventilation VATS (MV-VATS) from 2011 to 2018 were analyzed. 1:2 Propensity score matching (PSM) was applied, and the short- and long-term outcomes between the SV-VATS group and the MV-VATS group were compared.ResultsAnesthesia time (226.18 ± 64.89 min vs. 248.27 ± 76.07 min; P = 0.03), operative time (140.85 ± 76.07 min vs. 163.12 ± 69.37 min; P = 0.01), days of postoperative hospitalization (7.29 ± 3.35 days vs. 8.40 ± 7.89 days; P = 0.04), and days of chest tube use (4.15 ± 2.89 days vs. 5.15 ± 3.54 days; P = 0.01), the number of N1 station lymph node dissection (2.94 ± 3.24 vs. 4.34 ± 4.15; P = 0.005) and systemic immune-inflammation index (3855.43 ± 3618.61 vs. 2908.11 ± 2933.89; P = 0.04) were lower in SV-VATS group. Overall survival and disease-free survival were not significantly different between the two groups (OS: HR 0.66, 95% CI: 0.41–1.07, P = 0.09; DFS: HR 0.78, 95% CI: 0.42–1.45, P = 0.43).ConclusionsComparable short-term and long-term outcomes indicated that SV-VATS is a feasible and safe method and might be an alternative to MV-VATS when managing NSCLC patients with poor lung function.
Control of Ni/β-Ga2O3 Vertical Schottky Diode Output Parameters at Forward Bias by Insertion of a Graphene Layer
Authors: Labed Madani , Sengouga Nouredine , Rim You Seung 
Published: March 2022

Controlling the Schottky barrier height (ϕB) and other parameters of Schottky barrier diodes (SBD) is critical for many applications. In this work, the effect of inserting a graphene interfacial monolayer between a Ni Schottky metal and a β-Ga2O3 semiconductor was investigated using numerical simulation. We confirmed that the simulation-based on Ni workfunction, interfacial trap concentration, and surface electron affinity was well-matched with the actual device characterization. Insertion of the graphene layer achieved a remarkable decrease in the barrier height (ϕB), from 1.32 to 0.43 eV, and in the series resistance (RS), from 60.3 to 2.90 mΩ.cm2. However, the saturation current (JS) increased from 1.26×10−11 to 8.3×10−7(A/cm2). The effects of a graphene bandgap and workfunction were studied. With an increase in the graphene workfunction and bandgap, the Schottky barrier height and series resistance increased and the saturation current decreased. This behavior was related to the tunneling rate variations in the graphene layer. Therefore, control of Schottky barrier diode output parameters was achieved by monitoring the tunneling rate in the graphene layer (through the control of the bandgap) and by controlling the Schottky barrier height according to the Schottky–Mott role (through the control of the workfunction). Furthermore, a zero-bandgap and low-workfunction graphene layer behaves as an ohmic contact, which is in agreement with published results.
Les situations-images. Une approche fonctionnelle de l'imagerie dans les apprentissages scientifiques à l'école élémentaire
Authors: Mottet Gérard 
Published: March 2022

Cet article pose le problème crucial des relations entre images et activités dans le cadre des apprentissages scientifiques : quelle est la valeur opérative des images ?
Nous appuyant sur un ensemble de travaux de recherche et d’expérimentations dans des classes primaires, nous proposons, dans une première partie, un inventaire ordonné des situations qu’il est possible d’organiser autour des images. Cette classification permet de caractériser les différentes modalités de travail auxquelles peuvent donner lieu les images comme supports d’apprentissage dans différents domaines conceptuels.
Nous nous interrogeons ensuite sur les possibilités spécifiques qu’offrent les images pour apprendre les sciences : quelles en sont les pertinences sur le plan des constructions notionnelles et opératoires ? Nous insistons ici tout particulièrement sur les démarches de pensée et les parcours de connaissance qu’elles autorisent. Nous soulignons en conclusion les activités de mise en relation qu’elles sollicitent, favorisant ainsi la recherche d’équivalences et d'articulations entre les phénomènes.
Des images pour des activités scientifiques : apport des nouvelles technologies dans l'enseignement de la physique
Authors: Beaufils Daniel , Le Touzé Jean-Claude , Richoux Hélène , Richoux Bernard 
Published: March 2022

The use of images in science activities : how can computer techno¬ logy contribute to the teaching of physics ?
Daniel Beaufils Jean-Claude Le Touzé Hélène Richoux Bernard Richoux
Our research group at the Institut National de Recherche Pédagogique has been investigating the potential value of images for supporting scientific activities in physics teaching. We modified existing computer imaging software originally intended for laboratory use so that it could also be used in science teaching. We selected relevant professional scientific practices, we constructed software that would enable both tools and activities to be transposed to an educational setting, and we trialled scientific activities with school and university students. The use of pictures to measure, analyse and compare models with reality raises questions as to the nature and status of pictures (photographs, films, numeric pictures, calculated pictures, abstract graphics), and the capacities of learners or the difficulties they experience. In presenting our work, our aim is to illustrate how new questions for science education emerge from technological developments.
Images biologiques et activité de diagnostic d'élevage
Authors: Gay Alain , Gréa Jean , Sabatier Philippe 
Published: March 2022

Biological images and diagnosis in stock-breeding

Developing theoretical notions about form is central to learning biology. A biological form, however, is neither confined nor limited by a wall. It involves, rather, a dynamic process in which two components (the being, and its environment) are permanently associated, and distinguishable. These ideas are applied in computer software designed to aid diagnosis in stock-breeding, and involving : (a) a clear connection between the image and the accompanying text, which helps in interpreting the diagnostic signs observed ; (b) an aid in recognising symptoms, in the context of a problem-solving activity ; (c) the use of the computer tool in a particular situation, thus encouraging a two-way activity.
The results presented in this article are drawn from a study in the field of animal pathology. After visiting a breeding-station, learners consulted this software, which enabled them to identify the relevant signs of the pathological condition (from observation to description) and then relate the pathological form identified to the underlying explanation (from description to interpretation and from interpretation to action).
Le thème de la migration agricole en France
Authors: Rey Violette 
Published: March 2022

En 25 ans onze mille agriculteurs ont changé de région et conservé leur métier. Le bilan est modeste, il permet toutefois de mettre en valeur certains mécanismes qui intègrent le monde agricole dans le processus de mobilité générale de la société contemporaine. A la phase principale des années 50 -60, du mouvement des "hommes sans terres vers les terres sans hommes" entre la France de l'Ouest et la France du Sud Ouest a succédé la migration moins connue des agriculteurs du Bassin Parisien cherchant à la périphérie de leurs plaines de nouveaux espaces. Le retour des rapatriés et l'installation de quelques agriculteurs étrangers s'ajoutent au mouvement pour souligner combien est pressant le besoin de terres agricoles à des fins d'agrandissement d'exploitation et comment il a relayé le problème de la surcharge démographique et de l'inégale répartition de la population agricole dans la migration. En cela, la migration agricole parait procéder davantage d'un mécanisme de concentration des exploitations que d'un mécanisme de rééquilibrage spatial.
Après une approche du thème par le biais du vocabulaire et des courants économiques et sociologiques, l'article présente l'aide législative en faveur de la migration dans son contexte historique et le bilan du mouvement depuis 1949.
Élupubrations
Authors: Chatelain Martine 
Published: March 2022

Le motif folklorique du loup paraît en général marqué négativement : ancien démon menaçant, il est devenu une incarnation du diable, figure familière dans les légendes hagiographiques.
Mais en fait, l'existence dans son folklore de traits positifs, le déroulement de certains rites, et surtout sa coalition avec quelques saints, comme Jean-Baptiste, révèlent une dualité que le Christianisme n'a pas résolue malgré son effort de réinterprétation.
Or les composantes de cette structure duelle semblent souvent, dans le procès de certains rites ou jeux, se répartir selon un schéma alternatif de renversement qui pourrait être une solution médiane entre l'ambiguïté et la contradiction.
L'Assemblée des Femmes : les femmes, l'économie et la politique
Authors: Saïd Suzanne 
Published: March 2022

Dieser Artikel wirft die Frage nach dem Sinn der komischen Utopie und der Verwendung der Themen der Fraueniherrsehaft und des Kommunismus durch Aristophanes auf. In einer Welt, wo die Politik eine Angelegenheit der Männer ist, bedeutet die Ausübung der Macht durch Frauen, die nichts Männliches an sich haben, ein Mittel, die Korruption der demokratischen Einrichtungen und den Sieg des Privaten über das Oeffentliche aufzuzeigen. Athen, das sein Reich verloren hat und seine Einkünfte aus dem Landesinneren beziehen muss, verwandelt sich in ein riesiges von den Frauen verwaltetes Unternehmen.
Die Errichtung einer Güter -und Frauengemeinschaft, die die Logik der Demokratie auf die Spitze treibt, wobei sie die Gleichheit auf Eigentum und Geschlecht ausweitet, ist nur die Folge dieser ersten Umgestaltung. Die komische Utopie führt schliesslich zu einem dreifachen Misserfolg. Die Politik ist nur noch eine «Politik des Unterleibes» ; die Gütergemeinschaft ein Trugschluss und die Frauengemeinschaft ein unehrlicher Jahrmarkt.
Au-delà de la Thermodynamique des états d'équilibre
Authors: Pacault Adolphe 
Published: March 2022

L’enseignement d’une grande théorie, par exemple la thermodynamique, est plus justifié par le souci de former que par celui d’accumuler des connaissances.
C’est la raison pour laquelle les cinq parties suivantes devraient
constituer tout enseignement : [Schéma]
La première partie est générale et n’est pas spécifique de la thermodynamique, alors que la deuxième partie - épistémologique - en dépend plus particuIièrement. C’est grâce à ces connaissances générales que la partie centrale - le "noyau dur" - peut faire l’objet d’un enseignement axiomatique synthétique qui trouve, dans la quatrième partie, des applications variées choisies en fonction des objectifs poursuivis par les étudiants. La cinquième partie, enfin, rappelle qu’il n’y a pas de science morte et le renouveau de la thermodynamique en est la preuve.
Le contenu de ces cinq parties pourrait faire l’objet d’un ouvrage dont on a indiqué quelques aspects.