bluuebunny/crossref_metadata_2025_split huggingface dataset:
O modelo tridimensional e o processo de sucessão
Authors: De Fátima Teston Sayonara , Salete Filippim Eliane 
Published: June 2022

RESUMO

O objetivo geral da pesquisa foi investigar o processo de sucessão em empresas familiares à luz do modelo tridimensional de Gersick, Davis, Hampton e Lansberg (1997), o qual considera que há inter-relação entre família, empresa e propriedade em empresas desta natureza. Para contextualizar a arena das empresas familiares, estabeleceram-se critérios de ordem objetiva e conveniência, pois foi preceito a facilidade de acesso às informações familiares e organizacionais. Adotou-se predominantemente a perspectiva da pesquisa qualitativa de caráter descritivo, com método multi casos. A primeira frente de pesquisa foi a revisão bibliográfica, seguida pelas entrevistas, pesquisa documental e registro da observação em duas empresas do setor de serviços de Chapecó, Santa Catarina, Brasil. A interpretação dos resultados se deu cotejando os achados da realidade pesquisada com a literatura de base. Concluiu-se que o modelo tridimensional pode contribuir para preparar o sucessor para trilhar ações e tomar decisões, contudo este modelo não pode ser considerado como ação isolada para a realização da sucessão na empresa familiar.

Palavras-chave: Sucessão. Empresa familiar. Modelo tridimensional.
O FOG DIGITAL NOS CONSELHOS DE ADMINISTRAÇÃO - UMA REVISÃO DOS PROJETOS ESTRATÉGICOS DE UMA INSTITUIÇÃO FINANCEIRA
Authors: Villarinho Bruna , Thomaz Pereira Alexandre , Flavio Autran Monteiro Gomes Luiz 
Published: June 2022

RESUMO
A inovação digital vem promovendo significativa mudança na forma com que vivemos e fazemos negócios, fenômeno claramente percebido em todos os segmentos e geografias. Organizações pré-digitais, especialmente as de grande porte, demonstram particular hesitação e dificuldade para conseguirem realinhar suas iniciativas estratégicas às novas exigências mercadológicas. O presente artigo apresenta uma revisão do portfólio de projetos estratégicos aprovado pelo conselho de administração de uma instituição financeira, a partir da incorporação de novos critérios ao processo de tomada de decisão, cruciais para organizações que aspiram transformar-se digitalmente e manter-se competitivas.
Palavras-chave: Conselho de Administração. Governança Corporativa. Priorização de Portfólio. Multicritério de Apoio à Decisão. Transformação Digital.
O impacto da pandemia de Covid-19 na vida dos trabalhadores do setor turístico do Rio Grande do Norte: resultados e reflexões
Authors: Hofstaetter Moema , Sanson Cesar , Myrrha Luana Junqueira Dias , Macedo Luziene Dantas de 
Published: June 2022

O artigo tem por objetivo contextualizar o trabalhador do turismo na crise sanitária, econômica e social provocada pela pandemia Covid-19. Os autores fomentam este debate e sua problematização, através de uma pesquisa regional intitulada “Trabalhador do turismo e a Covid-19 no Rio Grande do Norte”, realizada entre os dias 14 a 22 de julho de 2020, quando ainda se mantinha fechada a maioria do comércio do Estado. Foram observados, o perfil demográfico e socioeconômico dos trabalhadores formais e informais do turismo, análise da renda e jornada antes e durante a pandemia e a expectativa dos trabalhadores sobre o futuro do turismo no RN. Como resultados, as principais consequências econômicas da Covid-19 para os trabalhadores do turismo foram: queda drástica da renda, demissões, flexibilização do contrato de trabalho e, redução da jornada de trabalho, ocasionadas pela diminuição de público a ser atendido. E, para os respondentes da pesquisa, o contexto da pandemia não traz boas expectativas sobre o futuro do turismo. O artigo finaliza com proposições que visam contribuir para o desenvolvimento regional, repensando o trabalho no turismo pós-pandêmico, através da inclusão social e do cuidado com o meio ambiente.
Determinantes da competitividade em destinos turísticos
Authors: Pessoa Martinz José , Gadotti dos Anjos Sara Joana , Lisboa Sohn Ana Paula 
Published: June 2022

O objetivo deste estudo é analisar a competitividade do destino turístico conforme os dados do Índice de Competitividade do Turismo Nacional. A pesquisa é caracterizada como exploratória, descritivo-explicativa. A metodologia, de natureza quantitativa, analisa os dados submetendo-os a testes estatísticos não-paramétricos para comparação e rankeamento dos destinos. Os resultados mostram que o destino turístico Fortaleza ocupa a 4ª posição no índice geral de competitividade. Observou-se em Fortaleza pontos fortes e fracos em relação a outros destinos turísticos localizados no nordeste do Brasil. Pode-se notar que suas principais forças estão ligadas aos indicadores de competitividade: acesso (2º colocado), infraestrutura turística (3ª colocação) e economia local (3º colocado). E, as fragilidades relacionadas aos indicadores: serviços (5º lugar); marketing (6ª posição); capacidade empresarial (6ª posição) e, aspectos ambientais (8ª posição).
Marketing Research of Supply and Demand in the Regional Energy Market
Authors: Alinazarova M. A. 
Published: June 2022

The study is devoted to the energy market of the Sughd region of the Republic of Tajikistan. The features of marketing in the energy sector are highlighted and the authors’ interpretations of the definition of “marketing” in the energy sector are given. The functions of marketing activities in the development of the energy sector of the region are considered. Examples of the correlation between supply and demand for energy products, including electricity, are given for further forecasting the consumption of these products. The ratio analysis of supply and demand of electricity in a certain area was carried out. To identify factors affecting the demand of electricity consumers, an analysis was carried out using statistical and mathematical calculation methods. As a result, a factor that has a greater influence on the demand of electricity consumers has been identified. The ways of solving marketing research for the further successful functioning of the energy company in the interests of society and the social well-being of the population are proposed.Purpose of the study. The purpose of this paper is to study the state of the regional energy market on the basis of marketing research that characterizes the activities of an energy company; identification of indicators such as consumer dissatisfaction with energy products. The paper is based on a dynamic analysis of analytical and statistical information about ongoing processes in the energy sector. The task is to conduct marketing research of supply and demand in the regional energy market.Materials and methods. The information base of the study is analytical information and statistical data on indexes of supply and demand for energy products, including electricity. The methodological basis of the study is represented by statistical methods of information analysis: comparative analysis and analysis of time series.Results. Based on the results of an economic and statistical analysis of consumer demand indicators for the use of energy products, including electricity, factors influencing demand have been identified. Of the three selected factors, it is especially worth noting the demand of consumers using electricity, which are population density indexes, weather conditions and the number of rainfall days in a particular region, it is theoretically established that population density is a more influential index.Conclusion. Energy is the main branch of the national economy of the country, which contributes to the development of the economy and the normal life of the population. Until now, the problem of providing the population and the national economy of the regions of the republic with energy goods and electricity makes us think about new ways to solve the problem. Since hydroelectric power generation in the country is the share of hydroelectric power plants, given the economic and social condition of the country in the power supply system, it will be appropriate to create a marketing system platform.
Statistical Analysis of the Patterns of Global Investment Development in China
Authors: Loseva A. V. 
Published: June 2022

The purpose of the study is to assess the possible impact of patterns and trends in the development of foreign investment activity of China on the prospects of Russian-Chinese economic cooperation in this area, including in terms of support for the Russian energy sector. The relevance of the study is due to the growing influence of the People’s Republic of China in solving global economic and political issues, as well as the importance of its role as a strategic partner of the Russian Federation, which makes it necessary to assess future prospects.The research methods are methods of analyzing time series, including identifying trends, as well as assessing the structure and structural shifts to obtain an overall picture of the structural transformations of foreign direct investment of China in regional and sectoral sections.The results of the study. Chinese foreign direct investment in the last two decades has been characterized by an intensive growth in volumes, resistant to global economic crises; analysis of their geographical structure demonstrates the constancy of such a feature as maximizing the opportunities of global offshore zones and countries granting privileges to foreign investors; the sectoral structure of Chinese foreign direct investment has certain patterns of change that are consistent with the goals and objectives of economic development of China set by five-year plans, which makes it possible to predict and find solutions in the field of Russian-Chinese cooperation; a trend has been identified to increase the attention of Chinese investors to the issue of capital formation in the Russian economy. In addition, an assessment of the analytical capabilities provided to users by the official statistics of China in terms of information about investment processes is given.Conclusion. Statistical analysis of the indicators of foreign investment activity of China over a long period of time allows us to evaluate and characterize its strategic behavior as one of the world’s largest investors, focused primarily on solving the problems of developing its own economy and its global expansion in the long term. The significance of such studies will now increase, given the importance of the development of foreign economic relations with China for the Russian Federation based on the increased potential of interaction between the two countries in recent years.
Overcome of Cisplatin Resistance in Ovarian Cancer by Combination of
Low-intensity Ultrasound and Cisplatin
Authors: Kip Bilgi , Aydin Omer 
Published: June 2022

Backgorund:
Platinum-based chemotherapeutics are the main treatment options for
ovarium cancer. However, the development of drug resistance is one of the major issues in chemotherapy.
Even targeting a specific pathway may not produce an efficient sensitization to the
chemo agent due to various pathways related to developing resistance against cisplatin. Hence,
more effective strategies against drug resistance are essential for cancer treatment. In the presence
of the ultrasonic waves, increased membrane porosity enables more drug uptake into the cancer
cell. Therefore, the promising method in cancer therapy is seen as the use of the combined effect
of chemotherapy and low-Intensity Ultrasound (LIUS) to overcome chemoresistance.

Objective:
The present study aimed to examine the effects of Ultrasound (US)+Cisplatin (Cis)-
based combination therapy to advance an effective treatment against drug resistance in cisplatinresistant
ovarian cancer cells A2780 (A2780cis) under in vitro conditions.

Methods:
Treatment groups as Cis and LIUS with two different ultrasound parameters (10% duty
cycle (DC), 1 MHz, 1.0 W/cm2, 1 min and 50% DC, 1 MHz, 1.0 W/cm2, 3 min) were investigated
to cope with the chemoresistance in A2780cis. After Cis therapy with IC50 concentrations determined
in A2780 and A2780cis, drug-sensitive/resistant ovarian cancer cells were treated by ultrasound.
The effects of the US+Cis combination therapy were evaluated by cell viability assays,
colony formation, and cell cycle analyses.

Results:
In both US parameters, the waveform was shown to be more effective in preventing drug
resistance. While more than 80% of the cell population was suppressed with the US+Cis combination
treatment, more than 90% of the colony formation was suppressed according to the colony
formation test results. In addition, US+Cis combination therapy caused different cell cycle arrests
in both A2780 and A2780cis cells.

Conclusion:
Ultrasound-based combination therapies show promising results in combating
chemoresistance, and the disadvantages of conventional cancer treatments, such as cancer recurrence,
drug resistance, and high cost, might reduce by the effectiveness of combination therapy of
ultrasound therapy and chemotherapy.
Primary Sjögren’s Syndrome Presenting with Rapidly Progressive
Dementia: A Case Report
Authors: Notas Konstantinos , Papaliagkas Vasileios , Spilioti Martha , Papagiannis Ioannis , Nemtsas Petros , Poulopoulos Athanasios , Kouskouras Konstantinos , Diakogiannis Ioannis , Kimiskidis Vasilios K. 
Published: June 2022

Background:
Rapidly progressive dementias (RPDs) are dementias that progress subacutely
over a time period of weeks to months. Primary Sjögren’s syndrome (pSS) is an autoimmune
disease that can affect any organ system and may present with a wide range of clinical features that
may mimic a plethora of medical conditions and, in rare cases, may manifest as RPD. We describe a
unique case of pSS, in which rapidly progressive dementia (RPD) was the first disease manifestation,
and the patient’s radiological and electroencephalogram findings were compatible with Creutzfeldt-
Jakob disease (CJD).

Case presentation:
Here, we report a 58-year-old woman who presented with cognitive impairment
rapidly deteriorating over the last 6 months prior to admission. Brain MRI and EEG were indicative
of CJD. However, CSF 14-3-3 and tau/phospho tau ratio were within normal limits and therefore alternative
diagnoses were considered. Blood tests were significant for positive antinuclear antibodies,
anti-ENA, and anti-SSA and a lip biopsy was consistent with pSS. The patient was started on intravenous
steroids followed by oral prednisone taper, which prevented further deterioration.

Conclusions:
This rare case expands the spectrum of neurological manifestations in pSS and highlights
the importance of considering pSS in the differential diagnosis of RPDs in order to avoid misdiagnosis
and provide appropriate treatment in a timely fashion.
Investigation of Psychoactive Medications: Challenges and a Practical and
Scalable New Path
Authors: Taliaz Dekel , Serretti Alessandro 
Published: June 2022

Abstract:
In the last two decades the validity of clinical trials in psychiatry has been subjected to discussion.
The most accepted clinical study method in the medical area, i.e. the randomized controlled
trial (RCT), faces significant problems when applied to the psychiatric field. One of the causes for this
scenario is the strict participant inclusion and exclusion criteria that may not represent the real world.
The inconsistency of the different endpoint parameters that are used in the field is another cause. We
think that psychiatric RCTs’ challenges, together with the underlying complexity of psychiatry, lead to
a problematic clinical practice. Psychoactive substances are currently routinely tested outside of a
formal clinical trial environment. Off-label psychoactive drugs are commonly prescribed, and other
substances, such as herbal remedies, are also regularly consumed. These real-life experiments can
teach us useful lessons. Real-world data (RWD) includes information about heterogeneous patient
populations, and it can be measured with standardized parameters. Collecting RWD can also address
the need for systematically documenting and sharing case reports’ outcomes. We suggest using digital
tools to capture objective and continuous behavioral data from patients passively. New conclusions
will be constantly drawn, possibly allowing more personalized treatment outcomes. The relevant nextgeneration
decision support tools are already available.
Antioxidant and Anti-inflammatory Activities Mediate the Radioprotective
Effect of Trianthema portulacastrum L. Extracts
Authors: Das Uttam , Saha Tanmay , Sharma Reshma Kumari , Maurya Dharmendra Kumar , Ray Partho Sarothi , Das Subir Kumar 
Published: June 2022

Background:
Ionizing radiation (IR) generates reactive oxygen species (ROS), which leads to oxidative stress that often leads to inflammatory responses in organisms.

Objective:
Trianthema portulacastrum L., a plant commonly growing in India, is rich in antioxidant phytochemicals. This is responsible for scavenging free radicals and may provide radioprotective and anti-inflammatory effects in response to ionizing radiation.

Methods:
The effect of T. portulacastrum extracts was studied in hepatic cells, which are susceptible to radiation-induced damage and in macrophages, which are the primary inflammatory cells of the body.

Results:
T. portulacastrum stem extracts showed efficient free radical scavenging activity in hepatocytes and decreased radiation-induced lipid peroxidation in cell and mitochondrial membranes. Treatment of irradiated cells with T. portulacastrum stem extracts enhanced cell viability at lower concentration and reduced cell viability at higher concentration. Treatment with low concentration of T. portulacastrum stem extract also reduced cellular ROS generation and increased the concentration of cellular anti-oxidant, glutathione. T. portulacastrum extracts also showed remarkable anti-inflammatory properties in macrophages activated by the inflammatory agonist bacterial lipopolysaccharide (LPS). The extract reduced nitric oxide (NO) production and suppressed the expression of inflammatory genes.

Conclusion:
Together, these observations demonstrated a potential radioprotective role of T. portulacastrum extract mediated by both its antioxidant activity on hepatic epithelial cells and its anti-inflammatory activity on immune cells.
Development of High Voltage DC Power Supply from Tesla Coil Using
Hybrid Energy Sources
Authors: Ahmed Amin Arslan , Yaseen Mobeen , Gufran Khan Muhammad , Adnan Muhammad , Mughees Abdullah , Mukhtar Mohsin 
Published: June 2022

Background:
High Voltage Direct Current (HVDC) is a well-proven technology used to transmit electricity over long distances by overhead transmission lines or submarine cables. It is also used to interconnect separate power systems, where traditional Alternating Current (AC) connections cannot be used.

Objective:
In this paper, an HVDC supply has been proposed with the Tesla coil using hybrid energy sources such as solar panels, batteries, and AC main supply with an AC-DC converter.

Method:
DC voltage is obtained from various hybrid sources and is supplied to the input of the Cockcroft-Walton (C-W) voltage multiplier circuit through DC/AC inversion.

Result:
The produced HVDC is provided to the Tesla coil to obtain a stable HVDC output. Fractional Order PID (FOPID) controller is used in the system for control purposes to stabilize the output voltage due to load variations. The model was designed in Matlab / Simulink environment. The simulation results show that the proposed design successfully achieved a stable 15 kV HVDC.

Conclusion:
The advantage of the proposed system is the availability of variable output voltage as per load requirement compared to the fixed limited output voltage generated by conventional HVDC systems.
Digital Health Literacy During the COVID-19 Pandemic Among Health Care Providers in Resource-Limited Settings: Cross-sectional Study
Authors: Ahmed Mohammedjud Hassen , Guadie Habtamu Alganeh , Ngusie Habtamu Setegn , Teferi Gizaw Hailiye , Gullslett Monika Knudsen , Hailegebreal Samuel , Hunde Mekonnen Kenate , Donacho Dereje Oljira , Tilahun Binyam , Siraj Shuayib Shemsu , Debele Gebiso Roba , Hajure Mohammedamin , Mengiste Shegaw Anagaw 
Published: June 2022

Background
Digital health literacy is the use of information and communication technology to support health and health care. Digital health literacy is becoming increasingly important as individuals continue to seek medical advice from various web-based sources, especially social media, during the pandemics such as COVID-19.

Objective
The study aimed to assess health professionals’ digital health literacy level and associated factors in Southwest Ethiopia in 2021.

Methods
An institution-based cross-sectional study was conducted from January to April 2021 in Ethiopia. Simple random sampling technique was used to select 423 study participants among health professionals. SPSS (version 20) software was used for data entry and analysis. A pretested self-administered questionnaire was used to collect the required data. Multivariable logistic regression was used to examine the association between the digital health literacy skill and associated factors. Significance value was obtained at 95% CI and P<.05.

Results
In total, 401 study subjects participated in the study. Overall, 43.6% (n=176) of respondents had high digital health literacy skills. High computer literacy (adjusted odds ratio [AOR] 4.43, 95% CI 2.34-5.67; P=.01); master’s degree and above (AOR 3.42, 95% CI 2.31-4.90; P=.02); internet use (AOR 4.00, 95% CI 1.78-4.02; P=.03); perceived ease of use (AOR 2.65, 95% CI 1.35-4.65; P=.04); monthly income of >15,000 Ethiopian birr (>US $283.68; AOR 7.55, 95% CI 6.43-9.44; P<.001); good knowledge of eHealth (AOR 2.22, 95% CI 1.32-4.03; P=.04); favorable attitudes (AOR 3.11, 95% CI 2.11-4.32; P=.04); and perceived usefulness (AOR 3.43, 95% CI 2.43-5.44; P=.02) were variables associated with eHealth literacy level.

Conclusions
In general, less than half of the study participants had a high digital health literacy level. High computer literacy, master’s degree and above, frequent internet use, perceived ease to use, income of >15,000 Ethiopian birr (>US $283.68), good knowledge of digital health literacy, favorable attitude, and perceived usefulness were the most determinant factors in the study. Having high computer literacy, frequent use of internet, perceived ease of use, perceived usefulness, favorable attitude, and a high level of education will help to promote a high level of digital health literacy.
Pengembangan Sistem Pengelompokan Sekolah Menggunakan Metode Algoritma K-Means (Studi Kasus Dinas Pendidikan Kabupaten Malang)
Authors: Noviansyah Moch. Rosid , Nuryasin Ilyas , Chandranegara Didih Rizki 
Published: June 2022

Sebuah instansi pemerintah yang bergerak di bidang pendidikan khususnya pendidikan smp tentunya Dinas Pendidikan Kabupaten Malang yang merupakan instansi penting sebagai penggerak pendidikan di wilayah kabupaten malang untuk mengukur suatu mutu dan kualitas - kualitas sekolah yang ada di Dinas Kabupaten Malang yaitu berdasarkan standart penilaian pendidikan dan Standart pengelolaan yang berupa Nilai Ujian Nasional, Nilai Ujian Sekolah, dan Nilai Akreditasi Sekolah, namun demikian mengingat banyaknya jumlah Sekolah Menengah Pertama atau dalam kasus ini adalah SMP yang ada di Kabupaten Malang, nilai Ujian Nasional, Ujian Sekolah, serta Nilai Akreditasi Sekolah dari tiap tiap sekolah tidak seragam tentu pihak Dinas Kabupaten Malang akan kesulitan dalam mencari dan memilah tiap tiap sekolah berdasarkan karakteristik tersebut. Maka penelitian ini membahas tentang penerapan data mining menggunakan metode Algoritma K-Means untuk menghasilkan tampilan profil yang memiliki atribut sama , atribut atau parameter nilai yang digunakan adalah rata rata nilai dari setiap sekolah dari nilai Ujian Nasional, nilai Ujian Sekolah, serta nilai Akreditasi Sekolah, dengan menghasilkan cluster sejumlah 3 (k = 3) dengan cluster1 sebanyak 33 data , cluster2 sebanyak 56 data, cluster3 sebanyak 49 data. Hal ini menunjukan nilai SSE paling besar dengan jumlah cluster sebanyak 3 dimana dengan jumlah cluster tersebut yang paling ideal untuk melakukan clustering sekolah SMP berdasarkan data di Dinas Pendidikan Kabupaten Malang.