bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelling the impact of lining and covering irrigation canals on underlying groundwater stores in the Nile Delta, Egypt
Authors: Abd‐Elaty Ismail , Pugliese Lorenzo , Bali Khaled M. , Grismer Mark E. , Eltarabily Mohamed Galal 
Published: December 2021

AbstractCanal seepage losses can contribute significantly to groundwater aquifers in arid and semi‐arid regions worldwide. In addition, surface water evaporation and evapotranspiration from adjacent riparian vegetation directly affect surface water availability across these regions. This study aims to evaluate interactions between irrigation canals and the Nile Delta groundwater aquifer in Egypt under four operational scenarios: (i) decreased stream flows in the four main diversion canals associated with upper Nile diversions and climate change, (ii) concrete lining of irrigation canals, (iii) combined lining and use of Photo‐Voltaic (PV) Solar Panel covers on canals and (iv) enclosure of the canals in closed conduits. We investigated the effects of these scenarios on regional groundwater supplies and levels using MODFLOW and water budget analyses. Decreased streamflow (scenario 1) resulted in decreased aquifer recharge (from 732 910 to 483 800 m3 day−1) and lower groundwater levels as compared to the base case (present) conditions. Moreover, groundwater flows from the aquifer to the four main canals noticeably increased from 23 176 to 79 364 m3 day−1. Water budget analyses associated with canal lining scenarios (2, 3, & 4) indicated that canal leakage to the aquifer accounted for 146 582, 146 582, and 73 291 m3 day−1 respectively. The changes in canal efficiencies reached 29.3%, 67.1%, 75.3%, and 91.8% while the changes in aquifer recharge efficiencies were 66%, 20%, 20%, and 10% for the four scenarios, respectively. Overall, we found that canals lining is likely the most suitable solution for managing water resources in the Nile Delta. Further aspects to be considered in future studies include the loss of biodiversity along streams embankments due to channel lining.
Two Dimensional Perovskites/Transition Metal Dichalcogenides Heterostructures: Puzzles and Challenges
Authors: Baranowski Michal , Surrente Alessandro , Plochocka Paulina 
Published: December 2021

AbstractTwo‐dimensional (2D) layered materials have been in the spotlight of scientists’ interest for more than a decade. The inherently weak interaction between the layers in 2D crystals allows stacking different materials and building heterostructures with novel functional properties. Here, we review the most recent advances on heterostructures composed of transition metal dichalcogenides and 2D perovskites. We show that combining these materials yields a rich and unique platform for the investigation of energy and charge transfer mechanisms, as well as band alignment engineering. We summarize the current understanding of the fascinating photophysics of these heterostructures, emphasizing the open questions related to their fundamental properties. We conclude by highlighting how this platform offers an unprecedented number of tuning knobs to control their optoelectronic properties and some potentially interesting directions to explore in the near future.
Service innovations in mobile banking for creating value for the poor in developing countries
Authors: Gaur Aakanksha , Potnis Devendra Dilip 
Published: December 2021

AbstractMobile banking is a service innovation in the banking industry. Extant research has demonstrated that the goal of any service innovation is to create value for stakeholders including consumers. Despite the consensus that information and communication technologies (ICTs) can be leveraged to deliver financial services to the poor, few studies have examined the process through which mobile banking service providers create value for consumers. Building on concepts from service‐dominant logic and service science, this paper posits that the delivery of such mobile banking services requires a repertoire of information and communication technology (ICT) as well as non‐ICT resources. Specifically, Cashpor a mobile banking service provider, that provides mobile banking financial services to rural females is examined. The research traces the implementation of key service innovations by configurations of three resources—people, technology, and information, and three mechanisms—knowledge integration, technology integration, and governance—through which value‐creating benefits of social, financial, and psychological benefits are achieved.
Anisodamine affects the pigmentation, mineral density, craniofacial area, and eye development in zebrafish embryos
Authors: Wang Binjie , Chen Tianyi , Wang Anli , Fang Jiakai , Wang Jiye , Yao Weixuan , Wu Yuanzhao 
Published: December 2021

AbstractAnisodamine is one of the major components of the tropine alkaloid family and is widely used in the treatment of pain, motion sickness, pupil dilatation, and detoxification of organophosphorus poisoning. As a muscarinic receptor antagonist, the low toxicity and moderate drug effect of anisodamine often result in high doses for clinical use, making it important to fully investigate its toxicity. In this study, zebrafish embryos were exposed to 1.3‐, 2.6‐, and 5.2‐mM anisodamine for 7 days to study the toxic effects of drug exposure on pigmentation, mineral density, craniofacial area, and eye development. The results showed that exposure to anisodamine at 1.3 mM resulted in cranial malformations and abnormal pigmentation in zebrafish embryos; 2.6‐ and 5.2‐mM anisodamine resulted in significant eye development defects and reduced bone density in zebrafish embryos. The associated toxicities were correlated with functional development of neural crest cells through gene expression (col1a2, ddb1, dicer1, mab21l1, mab21l2, sox10, tyrp1b, and mitfa) in the dose of 5.2‐mM exposed group. In conclusion, this study provides new evidence of the developmental toxicity of high doses of anisodamine in aqueous solutions to organisms and provides a warning for the safe use of this drug.
Modulation of the inflammatory response to decellularized collagen matrix for cartilage regeneration
Authors: Gvaramia David , Kern Johann , Jakob Yvonne , Tritschler Hanna , Brenner Rolf E. , Breiter Roman , Kzhyshkowska Julia , Rotter Nicole 
Published: December 2021

AbstractDecellularized extracellular matrices (DECM) are among the most common types of materials used in tissue engineering due to their cell instructive properties, biodegradability, and accessibility. Particularly in cartilage, a natural collagen type II matrix can be a promising means to provide the necessary cues and support for chondrogenic stem and progenitor cells (CSPCs). However, efficient remodeling of the transplanted DECM is largely dependent on the host immune response, with macrophages playing the central role in orchestrating both inflammatory and regenerative processes. Here we assessed the reaction of human primary macrophages to the cartilage DECM. Our findings show that the xenogeneic collagen matrix can elicit a mixed response in human macrophages, whereby the inflammatory response (M1) and the activation of remodeling (M2) type of macrophages are both present. Additionally, we demonstrate the inhibitory effect of macrophage response on the migratory capacity of human CSPCs. We further show that the inflammatory reaction of macrophages to the cartilage DECM, as well as the resulting inhibitory effects on CSPC migration, can be attenuated by interleukin‐4 (IL‐4). Finally, we demonstrate that IL‐4 can effectively bind the matrix, thereby modulating macrophage response by reducing the inflammatory reaction and inducing the M2 phenotype.
The wellbeing implications of maximizing: A conceptual framework and meta‐analysis
Authors: Belli Alex , Carrillat François A. , Zlatevska Natalina , Cowley Elizabeth 
Published: December 2021

AbstractDecision‐making literature establishes that maximizers, who always strive for the best option, paradoxically experience lower wellbeing. The current study aims to discover the conditions that attenuate or exacerbate the detrimental effect of maximization on wellbeing by using a large‐scale meta‐analysis based on 683 effect sizes from 108 papers, spanning 47,245 unique respondents. We develop a conceptual framework for the literature and classify potential moderators of the maximization‐wellbeing relationship along two dimensions: (i) whether they enable the decision‐maker to focus on the choice process or the choice outcome, and (ii) the extent to which they contribute to choice complexity, expecting that process (vs. outcome) focus and less complex choices can assuage maximizers’ wellbeing deficit. Our meta‐analysis supports our expectations for all the choice focus moderators, but not for all the choice complexity moderators. Alongside theoretical and practical implications, we offer a framework to guide future research that should uncover when choice complexity moderators most accurately explain the wellbeing of maximizers.
Hydrogen sulfide emissions from a midwestern manure slurry storage basin
Authors: Grant Richard H. , Boehm Matthew T. 
Published: December 2021

AbstractHydrogen sulfide (H2S) emissions from midwestern U.S. dairy lagoons are episodic and seasonal. Emissions were determined using an inverse diffusion model in conjunction with measured upwind and downwind line‐averaged H2S concentrations and turbulence. Mean daily H2S emissions from manure stored in earthen basins was 0.97 μg m−2 s−1 (σ = 1.35 μg m−2 s−1). Mean live animal basis daily emission from the basins was 1.1 g d−1 hd−1 (0.84 g d−1 AU−1). Daily emission was modeled using the van't Hoff function with air temperature as a surrogate for slurry surface temperature and a linear function of friction velocity. The mean standard error of estimate of the model was 1.8 μg m−2 s−1 (2.0 g d−1 hd−1, 1.6 g d−1 AU−1) and accounted for 60% of emissions variability. H2S emissions were enhanced for short periods during the year when the stored slurry was loaded onto trucks for removal. Emissions from the basins were not statistically different as barn manure handling changed from flushing to scraping. More measurements are needed to verify annual emissions estimates for these manure slurry storage basins and derive emission factors for these slurry storage systems.
A novel variant of C12orf4 linked to autosomal recessive intellectual disability type 66 with phenotype expansion
Authors: Rashvand Zahra , Kahrizi Kimia , Najmabadi Hossein , Najafipour Reza , Omrani Mir Davood 
Published: December 2021

AbstractBackgroundIntellectual disability (ID) is a hallmark of many rare disorders that are highly heterogeneous and complex. A large number of specific genes are involved in development of this heterogeneity, and each of these genes is only found in a small number of patients. This weakens the definition of the predominant genotype and the phenotypic characteristics associated with that gene. Autosomal recessive ID type 66 (OMIM #618221) is one of these very rare diseases created by defects in the C12orf4 gene.MethodsThe present study included two patients from an Iranian family with initial diagnosis of non‐syndromic ID, aiming to identify the possible genetic cause(s), and whole‐exome sequencing (WES) was performed for the proband. The obtained variant was confirmed by Sanger sequencing and co‐segregated in the family.ResultsThe patients carried a novel pathogenic splicing variant called c.1441‐1G>A in exon 12 of the C12orf4 gene (NM_001304811). They predominantly manifested ID, behavioral problems, speech impairment and dysmorphic facial features, some of which had not been reported in previous studies.ConclusionsA novel pathogenic splicing variant was identified named c.1441‐1G>A in the C12orf4 gene. To date, only seven families have been reported with defects in this gene. Previous studies have not highlighted the exact clinical manifestations of these patients; thus, the present study could contribute to a better delineation of the genotype–phenotype correlation and interpretation of very rare variants of the gene.
Eigenvalues and [a,b]‐factors in regular graphs
Authors: O Suil 
Published: December 2021

AbstractFor positive integers, , , and , Bollobás, Saito, and Wormald proved some sufficient conditions for an ‐edge‐connected ‐regular graph to have a ‐factor in 1985. Lu gave an upper bound for the third largest eigenvalue in a connected ‐regular graph to have a ‐factor in 2010. Gu found an upper bound for certain eigenvalues in an ‐edge‐connected ‐regular graph to have a ‐factor in 2014. For positive integers , an even (or odd) ‐factor of a graph is a spanning subgraph such that for each vertex , is even (or odd) and . In this paper, we prove upper bounds (in terms of and ) for certain eigenvalues (in terms of and ) in an ‐edge‐connected ‐regular graph to guarantee the existence of an even ‐factor or an odd ‐factor. This result extends the one of Bollbás, Saito, and Wormald, the one of Lu, and the one of Gu.
Characterization of chemical constituents in Shuanghuanglian oral dosage forms by ultra‐high performance liquid chromatography coupled with time‐of‐flight mass spectrometry
Authors: Li Ruiyun , Zhu Yanru , Ma Mingyan , Lei Min , Zhao Yingchun , Liu Ting , Yu Miao , Zhao Yunli , Yu Zhiguo 
Published: December 2021

AbstractShuanghuanglian is a common traditional Chinese medicine prescription. It is an herbal formula composed of Lonicerae Japonicae Flos, Scutellariae Radix, and Forsythiae Fructus. A comprehensive understanding of Shuanghuanglian oral dosage forms components was obtained using a method based on ultra‐high performance liquid chromatography coupled with time‐of‐flight mass spectrometry for the separation and characterization of Shuanghuanglian oral liquids, granules, soft capsules, and effervescent tablets. A total of 358 components were chemically defined or tentatively identified, including flavonoids, caffeic acid derivatives, lignans, coumarins, iridoids, triterpenes, and anthraquinones. The results will provide a basis for the general study of Shuanghuanglian and be meaningful for the composition identification of traditional Chinese medicine prescriptions.
Anatomy‐Based Frequency Allocation in Cochlear Implantation: The Importance of Cochlear Coverage
Authors: Aljazeeri Isra , Hamed Nezar , Abdelsamad Yassin , Sharif Tahir , Al‐Momani Murad , Hagr Abdulrahman 
Published: December 2021

Objectives/hypothesisThis study aimed to compare the predicted anatomy‐based frequency allocation of cochlear implant electrodes with the default standard frequencies.Study DesignRetrospective study.MethodsA retrospective analysis was performed using computed tomography (CT) images of patients who received cochlear implants at a tertiary referral center. Patients were excluded if they had any congenital or acquired cochlear anatomical anomalies. The CT images of the patients were uploaded to the surgical planning software. Two independent reviewers allocated the anatomical parameters of the cochlea. The software then used these parameters to calculate the frequency allocation for each electrode according to the type of electrode and the length of the organ of Corti (OC) in each patient. These anatomy‐based frequency allocations were compared with the default frequency settings.Main Outcome MeasureFrequency‐to‐place mismatch in semitones.ResultsA total of 169 implanted ears in 102 patients were included in this study. The readings of the two reviewers were homogenous, with a Cronbach's alpha of 0.98. The mean anatomy‐based frequency allocation was 487.3 ± 202.9 Hz in electrode 1; 9,298.6 ± 490.6 Hz in electrode 12. The anatomy‐based frequency allocations were found to be significantly higher than the frequencies of the default frequencies for each corresponding electrode (one‐sample t‐test, P < .001). The frequency‐to‐place mismatch was negatively correlated with cochlear coverage and positively correlated with the cochlear duct length (Pearson correlation > 0.65, P < .003).ConclusionsThe anatomy‐based frequency allocation of each electrode is significantly different from the default frequency setting. This frequency‐to‐place mismatch was affected mainly by the cochlear coverage.Level of Evidence3 Laryngoscope, 132:2224–2231, 2022
The combined anterolateral thigh—Partial iliac crest minihybrid free flap for mandibular reconstruction
Authors: Marttila Emilia , Salli Malla , Mesimäki Karri , Kainulainen Satu , Snäll Johanna , Wilkman Tommy 
Published: December 2021

AbstractBackground and aimsTumors of the oral cavity often require extensive resections leading to significant hard and soft tissue defects. Microvascular free flaps, consisting of both hard and soft tissue, are often required in reconstructions. Hybrid flaps, composed of two different joint free flaps, offer potential alternatives for head and neck reconstruction. This report presents our results with a modified hybrid ALT/DCIA, that is, minihybrid free flap (MH‐flap) composed of the anterolateral thigh (ALT) and a partial inner lamina iliac crest only (partial DCIA) for reconstruction of the mandibular region.Patients and methodsEight patients underwent oral cancer reconstruction of the mandible with the MH‐flap. The MH‐flap was harvested sparing the outer crest and lamina of crista, and its pedicle was combined to the distal pedicle of ALT. Clinical data and postoperative complications were analyzed.ResultsThe mean length of the osseous graft was 64 mm (range 54–78 mm). None of the patients had complications requiring surgical intervention. No donor site complications were observed. The overall survival rate was 100%. The mean length of follow‐up was 16 months (range 7–30 months).ConclusionsAccording to our results, the ALT‐partial DCIA MH‐flap has postoperative outcomes comparable to those of the fibular flap. The flap is a good option with excellent bone properties for reconstruction of limited mandibular defects not suitable for fibular or scapular reconstruction.
Surface modification of polytetrafluoroethylene film by argon cold atmospheric pressure plasmas for enhancing bonding with graphene‐filled polyimide adhesives
Authors: Lin Yung‐Sen , Wan Hsiang‐Yu , Wu Bing‐Rong 
Published: December 2021

AbstractSignificantly enhanced adhesion of polytetrafluoroethylene (PTFE) films to graphene‐filled polyimide (PI) adhesives by argon (Ar) cold atmospheric pressure plasmas (CAPPs) at the exposure durations of 72–96 s was undertaken. Poor adhesion of PTFE film to PI adhesive with no bonding (100% delamination) was highly improved to good bonding (100% attachment) for PTFE film treated by Ar CAPPs. Hydrophobic PTFE surface (water contact angle up to 91.1°) was changed to hydrophilic PTFE surfaces (water contact angle up to 37.4°–66.0°) with Ar CAPPs treatment by formation of polar chemical bonds such as C–O and C=O. To realize how the chemical bonds of C–O and C=O were produced onto the PTFE surface by Ar CAPPs, the plasma active species of Ar CAPPs were detected by optical emission spectroscopy.
Use of naldemedine is associated with reduced incidence of hyperactive delirium in cancer patients with opioid‐induced constipation: A nationwide retrospective cohort study in Japan
Authors: Abe Hiroaki , Sumitani Masahiko , Matsui Hiroki , Inoue Reo , Fushimi Kiyohide , Uchida Kanji , Yasunaga Hideo 
Published: December 2021

AbstractBackgroundMedical benefits of peripherally acting mu‐opioid receptor antagonists other than improving opioid‐induced constipation remain unclear. Our aim was to evaluate the association between the use of naldemedine and incidence of hyperactive delirium in cancer patients receiving chemotherapy and opioid therapy.MethodsWe conducted a propensity score‐matched analysis using a nationwide inpatient database in Japan. Cancer patients receiving both inpatient chemotherapy and opioid therapy from June 1, 2017, to March 31, 2018, were included. Patients receiving naldemedine were matched to control patients by propensity score. Our primary outcome was the incidence of hyperactive delirium during hospitalization, and secondary outcomes were the length of hospital stay, hospital costs, in‐hospital mortality, and incidence of ileus.ResultsOf 34,031 patients receiving inpatient chemotherapy and opioid therapy, 1905 (5.6%) were included in the naldemedine group. After one‐to‐four propensity score matching, 1904 patients were included in the naldemedine group and 7616 in the control group. Naldemedine users had significantly reduced incidence of hyperactive delirium compared with the control patients (19.4% vs 23.3%; risk difference, −3.9 [95% confidence interval, −5.9 to −1.9]; risk ratio, 0.83 [0.75–0.92]; p<0.001; subdistribution hazard ratio, 0.85 [0.75–0.97]; p = 0.015). The median length of hospital stay was significantly shorter in the naldemedine group compared with the control group (12 days [interquartile range, 6–23] vs 14 days [6–26]; p = 0.001). The median hospital costs were also significantly lower in the naldemedine group compared with the control group (US $6179 [3351–10,026] vs US $6576 [3436–11,107]; p < 0.001). No significant differences were found for in‐hospital mortality or incidence of ileus between the groups.ConclusionsOur findings suggest that the use of naldemedine may have benefits in preventing hyperactive delirium, shortening hospital stay, and decreasing hospital costs in cancer patients receiving chemotherapy and opioid therapy.
A comprehensive computational investigations on the physical properties of TiXSb (X: Ru, Pt) half‐Heusler alloys and Ti2RuPtSb2 double half‐Heusler
Authors: Rached Youcef , Caid Messaoud , Merabet Mostefa , Benalia Salaheddine , Rached Habib , Djoudi Lakhdar , Mokhtari Mohamed , Rached Djamel 
Published: December 2021

AbstractIn this paper, we have investigated the structural, elastic, optoelectronic and thermoelectric properties of the new half‐Heusler alloys TiXSb (X: Ru, Pt) and Ti2RuPtSb2 double half‐Heusler compound, using the full‐potential linearized augmented plane wave method. Different approximations for the exchange‐correlation functional were performed as generalized gradient approximation + Hubbard potential (GGA + U) and its combination with the modified Becke–Johnson potential. The negative values of the calculated formation energy indicate that these compounds are energetically stable. Both half Heusler alloys are half‐metallic ferromagnetic materials and exhibit an integer magnetic moment of Mt = 1.00 μB. While, the Ti2RuPtSb2 is a direct semiconductor at center symmetry. The calculations of optical properties revealed that Ti2RuPtSb2 compound exhibits an excellent optical efficiency. The thermoelectric properties such as the Seebeck coefficient (S); electronic thermal conductivity (κe/τ), power factor (PF), and figure of merit (ZT) have been studied and discussed in detail. Consequently, the investigated compounds were identified as candidate materials for high technological applications.
Pathway‐Selection for Programmable Assembly of Genetically Encoded Amphiphiles by Thermal Processing
Authors: Khodaverdi Masoumeh , Hossain Md Shahadat , Zhang Zhe , Martino Robert P. , Nehls Connor W. , Mozhdehi Davoud 
Published: December 2021

AbstractThe front cover artwork is provided by the Mozhdehi group at Syracuse University. The image shows an artistic representation of the recombinant production of lipoprotein coacervates. Thermal processing of these coacervates alters their hierarchical assembly and produces nanoaggregates with exquisite morphologies, such as braids and toroids. Read the full text of the Article at 10.1002/syst.202100037.