bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Highly Efficient Luminescent Metal–Organic Framework with Strong Conjugate Unit for Sensing Small Molecules
Authors: Chai Bi‐Lian , Xu Hui , Zheng Teng‐Fei , Chen Jing‐Lin , Liu Sui‐Jun , Yu Mei‐Hui , Wen He‐Rui 
Published: February 2022

Comprehensive SummaryLuminescent metal–organic frameworks (LMOFs) have become a promising class of fluorescence sensing materials, however, the multi‐responsive LMOF sensors for organic compounds are rather rare. Herein, a water stable and highly efficient luminescent MOF with the formula of {[Zn(BBZB)(2,6‐NDC)]·solvents}n (JXUST‐10, BBZB = 4,7‐bis(1H‐benzimidazole‐1‐yl)‐2,1,3‐benzothiadiazole and 2,6‐NDC = 2,6‐naphthalenedicarboxylate) was constructed by the incorporation of Zn2+ and two organic ligands (BBZB and 2,6‐NDC) featuring the conjugate system. JXUST‐10 is a three‐dimensional two‐fold interpenetrated framework with good fluorescent property. Based on the luminescent characteristic, JXUST‐10 can be used as a multi‐responsive sensor for detection of three different analytes including tetracycline, benzaldehyde and uric acid via different luminescent change behaviours. Remarkably, fluorescence test paper and LED light devices are used to detect analytes through the visual change of luminescence colour of JXUST‐10 from blue greenish to yellow greenish under ultraviolet light (365 nm) irradiation. Furthermore, the probable sensing mechanisms for three target analytes were also discussed.
Dynamics Study of the Self‐assembly of an Amphipathic Heptapeptide and Its Application as Glucosidase Mimetic
Authors: He Xingxing , Wang Xueqing , Liu Jifeng , Wang Shuo 
Published: February 2022

AbstractControlled peptide assembly is an important approach for the synthesis of materials with diverse functions, which opened up new frontiers in polymer science. Herein, we have qualitatively evaluated the morphological changes of the self‐assembly heptapeptide “Fmoc‐AEAEAEA‐CONH2” under various experimental conditions by transmission electron microscopy. The results showed that the morphology of the self‐assembled heptapeptide were found to be strongly influenced by the temperature, pH and solvents. And the heptapeptide can form two assemblies, nanofibers and cubes, depending on the kinetic parameters during the fabrication. It was concluded that the rebalance of molecular interactions such as hydrophobic interactions, hydrogen bonding and electrostatic interactions between peptides are responsible for the conversion of morphology. Additionally, the two assemblies could be utilized as the β‐glucosidase mimics, and the catalytic activity of the hydrolases mimics followed the density of active sites outside the assemblies. This finding provided a new perspective to understanding the process of self‐assembling and the potential relationship between block architectures and the generation of efficient artificial enzymes.
Virtual Colour Atlas
Authors: Smith Neville S. , Fairchild Mark D. 
Published: February 2022

AbstractA web application (Virtual Colour Atlas) has been developed that implements seven of the leading color order systems: Colorcurve, Coloroid, DIN 6164, Munsell, OSA‐UCS, NCS, and Swiss Colour Atlas 2541, three color spaces: CIE xyY, CIELAB, and CIELUV, and three colour ranges: BS:5252, RAL 840‐HR, and RAL 841‐GL—allowing the user to view any of the core planes in the color space of each of these systems. The Virtual Colour Atlas is freely available at (www.vcsconsulting.uk) and provides visual interaction with these systems using any modern browser hosted on a device with a sufficiently large physical display including: windows PCs, Macs, iPads, Linux devices, and smart televisions (HD to 8 K). This paper provides a brief background on the systems, describes the Virtual Colour Atlas software and history, and discusses example applications of the Virtual Colour Atlas.
Simple sequence repeat marker development and diversity analysis in buffalograss
Authors: Marshall Collin , Warnke Scott , Amundsen Keenan 
Published: February 2022

AbstractBuffalograss [Buchloë dactyloides (Nutt.) Engelm. syn. Bouteloua dactyloides (Nutt.) Columbus] is a stoloniferous low input turfgrass species native to the central Great Plains of the United States. Several molecular marker techniques have been used to compare relationships among elite buffalograss germplasm, but most rely on random amplification, are transferred from other species, or are developed from limited DNA sequence information. The objectives of this study were to develop buffalograss derived simple sequence repeat markers (SSRs) from buffalograss sequence data using an in‐silico bioinformatics pipeline and use high resolution melt analysis to screen the SSRs based on their melt profiles on buffalograss cultivars and germplasm. Transcriptomes from buffalograss cultivars ‘378’ and ‘Prestige’ were mined for SSRs using the MIcroSAtellite tool. There were 259 conserved SSRs that were polymorphic between 378 and Prestige. Of those, 96 were tested by HRM on a panel of eight genotypes and 24 were selected for producing melt profiles that could distinguish the genotypes. The selected reactions produced 356 distinct melt profiles when tested on a panel of 96 genotypes, including 88 buffalograss germplasm selections, six buffalograss cultivars, and two blue grama [Bouteloua gracilis (H. B. K.) Lag. ex Steud.] selections, with melt profile frequencies ranging from 0.01 to 0.97. A subset of 86 melt profiles segregating among the blue grama and elite buffalograss cultivars distinguished each genotype. The buffalograss‐specific SSR markers presented here will be useful to study buffalograss genetic diversity, line purity maintenance, and for marker supported plant breeding strategies.
Prevalent, persistent, and impairing: Longitudinal course and impact of apathy in Alzheimer's disease
Authors: Grossman Hillel T. , Sano Mary , Aloysi Amy , Elder Gregory A. , Neugroschl Judith , Schimming Corbett , Soleimani Laili , Zhu Carolyn W. 
Published: February 2022

AbstractIntroductionUnderstanding of the natural history of apathy and its impact on patient function is limited. This study examines, in a large, national sample of Alzheimer's disease (AD) patients with long follow‐ups: (1) prevalence, incidence, and persistence of apathy, and (2) impact of apathy on function across dementia severity.MethodsA longitudinal study of 9823 well‐characterized AD patients in the National Alzheimer's Coordinating Center Uniform Data Set.ResultsApathy was highly prevalent across disease severity with cumulative prevalence of 48%, 74%, and 82% in Clinical Dementia Rating (CDR) 0.5, 1.0, and 2.0, respectively. Persistence of apathy from clinician judgment varied from visit to visit at earlier disease stages but remained high at moderate dementia. Independent of cognition, persistent apathy was strongly associated with accelerated rate of functional decline.DiscussionFindings point to important targets for the treatment and management of apathy, include functional outcomes, and study designs that account for variable persistence of the apathy syndrome.
Plasma microRNA vary in association with the progression of Alzheimer's disease
Authors: Guévremont Diane , Tsui Helen , Knight Robert , Fowler Chris J. , Masters Colin L. , Martins Ralph N. , Abraham Wickliffe C. , Tate Warren P. , Cutfield Nicholas J. , Williams Joanna M. 
Published: February 2022

AbstractIntroductionEarly intervention in Alzheimer's disease (AD) requires the development of an easily administered test that is able to identify those at risk. Focusing on microRNA robustly detected in plasma and standardizing the analysis strategy, we sought to identify disease‐stage specific biomarkers.MethodsUsing TaqMan microfluidics arrays and a statistical consensus approach, we assessed plasma levels of 185 neurodegeneration‐related microRNA, in cohorts of cognitively normal amyloid β‐positive (CN‐Aβ+), mild cognitive impairment (MCI), and Alzheimer's disease (AD) participants, relative to their respective controls.ResultsDistinct disease stage microRNA biomarkers were identified, shown to predict membership of the groups (area under the curve [AUC] >0.8) and were altered dynamically with AD progression in a longitudinal study. Bioinformatics demonstrated that these microRNA target known AD‐related pathways, such as the Phosphoinositide 3‐kinase (PI3K‐Akt) signalling pathway. Furthermore, a significant correlation was found between miR‐27a‐3p, miR‐27b‐3p, and miR‐324‐5p and amyloid beta load.DiscussionOur results show that microRNA signatures alter throughout the progression of AD, reflect the underlying disease pathology, and may prove to be useful diagnostic markers.
Standing up or giving up? Moral foundations mediate political differences in evaluations of BLACK LIVES MATTER and other protests
Authors: Richardson Isaac , Conway Paul 
Published: February 2022

AbstractBlack Lives Matter (BLM) protests challenge the existing social order whereas other protests do not (e.g., gun‐rights protests). Some protests even reinforce it (e.g., Blue Lives Matter protests). Protests challenging the social order align with “individualizing” moral foundations (e.g., fairness, harm/care) but undermine “binding” moral foundations (e.g., loyalty, authority), which may partially explain political differences in approval of protesting. Four studies examined whether moral foundation endorsement mediated the effect of political orientation on protest evaluations. In Study 1, liberals rated BLM protests and general protesting as more moral than conservatives, partially due to increased individualizing and decreased binding endorsement. Studies 2–4 replicated this pattern for BLM and general protesting, but these effects disappeared for gun‐rights protests and largely reversed for Blue Lives Matter protests, which uphold the status quo. These results suggest that protest evaluations partially reflect the moral values prioritized by different political groups.
The interplay between audiovisual temporal synchrony and semantic congruency in the cross‐modal boost of the visual target discrimination during the attentional blink
Authors: Zhao Song , Wang Chongzhi , Feng Chengzhi , Wang Yijun , Feng Wenfeng 
Published: February 2022

AbstractThe visual attentional blink can be substantially reduced by delivering a task‐irrelevant sound synchronously with the second visual target (T2), and this effect is further modulated by the semantic congruency between the sound and T2. However, whether the cross‐modal benefit originates from audiovisual interactions or sound‐induced alertness remains controversial, and whether the semantic congruency effect is contingent on audiovisual temporal synchrony needs further investigation. The current study investigated these questions by recording event‐related potentials (ERPs) in a visual attentional blink task wherein a sound could either synchronize with T2, precede T2 by 200 ms, be delayed by 100 ms, or be absent, and could be either semantically congruent or incongruent with T2 when delivered. The behavioral data showed that both the cross‐modal boost of T2 discrimination and the further semantic modulation were the largest when the sound synchronized with T2. In parallel, the ERP data yielded that both the early occipital cross‐modal P195 component (192–228 ms after T2 onset) and late parietal cross‐modal N440 component (424–448 ms) were prominent only when the sound synchronized with T2, with the former being elicited solely when the sound was further semantically congruent whereas the latter occurring only when that sound was incongruent. These findings demonstrate not only that the cross‐modal boost of T2 discrimination during the attentional blink stems from early audiovisual interactions and the semantic congruency effect depends on audiovisual temporal synchrony, but also that the semantic modulation can unfold at the early stage of visual discrimination processing.
Prevalence and Risk Factors of Advanced Liver Fibrosis in a Population‐Based Study in Germany
Authors: Huber Yvonne , Schulz Andreas , Schmidtmann Irene , Beutel Manfred , Pfeiffer Norbert , Münzel Thomas , Galle Peter R. , Wild Philipp S. , Lackner Karl J. , Schattenberg Jörn M. 
Published: February 2022

The prevalence of liver disease, and especially of advanced liver fibrosis, in the German population is poorly defined. The aim of the study was to explore liver enzymes and surrogate scores of hepatic steatosis and advanced hepatic fibrosis in a population‐based cohort study in Germany. In the cross‐sectional population‐based Gutenberg Health study, data of 14,950 participants enrolled between 2007 and 2012 were captured and analyzed. The distribution of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma‐glutamyltransferase (GGT), fatty liver index (FLI), and Fibrosis‐4 (FIB‐4) score, as well as the underlying risk factors, were assessed by regression models. Elevated liver enzymes in this population‐based sample were seen in 19.9% for ALT, 12.8% for AST, and 14% for GGT. Risk factors for liver disease included alcohol use and the presence of the metabolic syndrome, which were both risk factors associated with increased liver enzymes. The FLI suggested that 37.5% of the population exhibited hepatic steatosis and 1.1% of patients exhibited a FIB‐4 above the upper cutoff, while 19.2% were in the intermediate range. Interestingly, advanced fibrosis was significantly more frequent in men compared with women (FIB‐4: 1.5% vs. 0.6% [P < 0.0001]; NFS: 3.6% vs. 1.9% [P < 0.0001]). In addition, age was a relevant risk factor for exhibiting a noninvasive surrogate score suggestive of advanced fibrosis in the current study population. Conclusion: Elevated liver enzymes were seen in almost a fifth of the German population. At the population‐based level, the prevalence of advanced fibrosis was estimated at 1% in Germany.
Suspected neuropsychomotor developmental delay in the first 2 years of life in a birth cohort in the Brazilian Amazon: Incidence, persistence and risk factors
Authors: Araujo Waleska Regina Machado , Malta Maíra Barreto , Faggiani Lucas Damasio , Cardoso Marly Augusto , Matijasevich Alicia ,   for the MINA‐Brazil Study Group
Published: February 2022

AbstractWe estimated risk factors associated with suspected neuropsychomotor developmental delay at age 2 years, in a birth cohort in the Brazilian Amazon. The Maternal and Child Health and Nutrition in Acre (MINA‐Brasil) study is a population‐based birth cohort involving children born between July 2015 and June 2016 in the municipality of Cruzeiro do Sul, in the Brazilian state of Acre. We assessed neuropsychomotor development in 735 and 819 children at one and 2 years of age, respectively, using the Denver II screening test. Multivariate Poisson regression models were used to investigate the factors associated with suspected developmental delay at age 2 years. The frequency of suspected developmental delay was 29.5 and 51.0% at one and 2 years of age, respectively, with a cumulative incidence of 41.6% and a persistence of 60.6% between the first and second years of life. After adjustment, the risk of developmental delay at 2 years of age was found to be higher for children born to women with fewer years of education and whose mothers had urinary tract infection during pregnancy. Other risk factors included male sex, low height for age at 2 years, malaria at childhood, pacifier use and limited child stimulation at age 2 years.
Nutritional interventions to ameliorate the effect of endocrine disruptors on human reproductive health: A semi‐structured review from FIGO
Authors: Corbett Gillian A. , Lee Sadhbh , Woodruff Tracey J. , Hanson Mark , Hod Moshe , Charlesworth Anne Marie , Giudice Linda , Conry Jeanne , McAuliffe Fionnuala M. ,   International Federation of Gynecology and Obstetrics (FIGO) Committee on Impact of Pregnancy on Long‐term Health and the FIGO Committee on Climate Change and Toxic Environmental Exposures
Published: February 2022

AbstractBackgroundEndocrine disrupting chemicals have harmful effects on reproductive, perinatal, and obstetric outcomes.ObjectiveTo analyze the evidence on nutritional interventions to reduce the negative effects of endocrine disruptors on reproductive, perinatal, and obstetric outcomes.Search strategyA search of MEDLINE (PubMed), Allied Health Literature (CINAHL), EMBASE, Web of Science, and the Cochrane Database was conducted from inception to May 2021.Selection criteriaExperimental studies on human populations.Data collection and analysisData were collected from eligible studies. Risk of bias assessment was completed using the Cochrane risk of bias tool and the ROBINS‐I Tool.ResultsDatabase searches yielded 15 362 articles. Removing 11 181 duplicates, 4181 articles underwent abstract screening, 26 articles were eligible for full manuscript review, and 16 met full inclusion criteria. Several interventions were found to be effective in reducing exposure to endocrine disruptors: avoidance of plastic containers, bottles, and packaging; avoidance of canned food/beverages; consumption of fresh and organic food; avoidance of fast/processed foods; and supplementation with vitamin C, iodine, and folic acid. There were some interventional studies examining therapies to improve clinical outcomes related to endocrine disruptors.ConclusionDietary alterations can reduce exposure to endocrine disruptors, with limited data on interventions to improve endocrine‐disruptor–related clinical outcomes. This review provides useful instruction to women, their families, healthcare providers, and regulatory bodies.
Seroreduction of syphilis non‐treponemal titers during pregnancy for women with and without HIV co‐infection
Authors: Webster Carolyn M. , Kasaro Margaret P. , Price Joan T. , Stringer Elizabeth M. , Wiesen Christopher A. , Vwalika Bellington , Stringer Jeffrey S. A. 
Published: February 2022

AbstractObjectiveTo evaluate the effect of HIV co‐infection on non‐treponemal titers during pregnancy in women with syphilis.MethodsThis is a secondary analysis of pregnant women with syphilis in the prospective, observational Zambian Preterm Birth Prevention Study (ZAPPS). Treponemal (Treponema pallidum particle agglutination) and non‐treponemal (rapid plasma reagin; RPR) testing were performed on serum biospecimens, resulting in 47 participants with serologically confirmed syphilis (27 HIV‐positive, 20 HIV‐negative). The primary outcome, achievement of RPR titer seroreduction during pregnancy, was analyzed by logistic regression. Secondary outcomes included overall titer reduction, seroreduction rate, serologic cure, and adverse pregnancy outcomes.ResultsSeroreduction of RPR titer occurred in 78% (21/27) of women with HIV versus 45% (9/20) of women without (adjusted odds ratio 4.66; 95% confidence interval [CI] 1.14 − 19.08). Overall RPR titer reduction, rate of seroreduction per week, and the proportion achieving serologic cure each trended higher among women with HIV compared with those without HIV. There was a trend toward decreased stillbirth incidence in participants achieving seroreduction (odds ratio 0.15, 95% CI 0.01–1.58).ConclusionHIV co‐infection in this cohort of Zambian women with syphilis was associated with greater odds of RPR titer seroreduction during pregnancy. Pregnant women with syphilis and HIV may not be at increased risk for a delayed syphilis treatment response compared with women without HIV.
Patient‐reported outcome measures for pregnancy‐related urinary and fecal incontinence: A prospective cohort study in a large Italian population
Authors: Ferrari Amerigo , Bonciani Manila , Russo Eleonora , Mannella Paolo , Simoncini Tommaso , Vainieri Milena 
Published: February 2022

AbstractObjectiveTo investigate prevalence and risk factors of pregnancy‐related urinary/fecal incontinence (UI/FI) in a large Italian population.MethodsThis is a prospective cohort study analyzing patient‐reported outcome (PRO) measures obtained from the systematic longitudinal survey on the maternity pathway of Tuscany from March 2019 to April 2021. Four questionnaires were completed by 6023 women from the beginning of pregnancy until 6 months postpartum, each including two PRO measures—Wexner scale for FI and ICIQ‐SF for UI–, and questions investigating sociodemographic/clinical factors. After assessing UI/FI prevalence at each time‐point, we run panel regressions to explore the related risk factors.ResultsWomen reporting UI and FI were, respectively, 24.3% and 6.2% in the third trimester, and 12.6% and 4.2% 6 months postpartum. UI occurrence and severity were higher in highly educated, aged >30, and overweight/obese women. Spontaneous tears or episiotomy were risk factors for postpartum UI, while receiving cesarean‐section and performing pelvic‐floor‐muscle‐training during pregnancy were protective, mainly in specific groups. Finally, higher FI prevalence and severity emerged in overweight, aged >40, highly educated, non‐Italian women and in those undergoing tears.ConclusionWe employed PRO measures to investigate the epidemiology of pregnancy‐related UI/FI and detect the main risk groups. Pelvic‐floor‐muscle‐training may be recommended in women with peculiar sociodemographic/clinical features.
Attitudes toward Homelessness Inventory: A psychometric analysis
Authors: Snow‐Hill Nyssa L. , Kloos Bret 
Published: February 2022

AbstractThe Attitudes toward Homelessness Inventory (ATHI) was developed due to a lack of psychometrically sound instruments to measure the nature and change in attitudes toward homelessness. Given inconsistencies in its use and internal reliability, this study evaluates the psychometric properties of the ATHI. Participants (n = 899) were selected using a random‐digit‐dial telephone survey to complete the ATHI. Results demonstrated that the four‐factor solution suggested by the ATHI developers was the best fit for the data, but factor loadings and reliability coefficients were not sufficient for ensuring adequate measurement of attitudes toward homelessness. The poor psychometrics found in this study were likely the result of now outdated items. While the ATHI was developed using well‐regarded and rigorous methods, results from this study suggest that it may be necessary to either make edits to the ATHI or to develop a new conceptually and psychometrically‐sound measure.