bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pacemaker implantation after sutureless or stented valve: results from a controlled randomized trial
Authors: Lorusso Roberto , Ravaux Justine M , Pollari Francesco , Folliguet Thierry A , Kappert Utz , Meuris Bart , Shrestha Malakh L , Roselli Eric E , Bonaros Nikolaos , Fabre Olivier , Corbi Pierre , Troise Giovanni , Andreas Martin , Pinaud Frederic , Pfeiffer Steffen , Kueri Sami , Tan Erwin , Voisine Pierre , Girdauskas Evaldas , Rega Filip , Garcia-Puente Julio , Fischlein Theodor ,   on behalf the PERSIST-AVR Investigators, Fischlein Theodor , Lorusso Roberto , Folliguet Thierry , Shrestha Malakh , Meuris Bart , Roselli Eric , Kappetein Arie Pieter , Gaggianesi Sara 
Published: February 2022

Abstract

OBJECTIVES
Sutureless aortic valves demonstrated non-inferiority to standard stented valves for major cardiovascular and cerebral events at 1 year after aortic valve replacement. We aim to assess the factors correlating with permanent pacemaker implantation (PPI) in both cohorts.

METHODS
PERSIST-AVR is a prospective, randomized, open-label trial. Patients undergoing aortic valve replacement were randomized to receive a sutureless aortic valve replacement (Su-AVR) or stented sutured bioprosthesis (SAVR). Multivariable analysis was performed to identify possible independent risk factors associated with PPI. A logistic regression analysis was performed to estimate the risk of PPI associated to different valve size.

RESULTS
The 2 groups (Su-AVR; n = 450, SAVR n = 446) were well balanced in terms of preoperative risk factors. Early PPI rates were 10.4% in the Su-AVR group and 3.1% in the SAVR. PPI prevalence correlated with valve size XL (P = 0.0119) and preoperative conduction disturbances (P = 0.0079) in the Su-AVR group. No predictors were found in the SAVR cohort. Logistic regression analysis showed a significantly higher risk for PPI with size XL compared to each individual sutureless valve sizes [odds ratio (OR) 0.272 vs size S (95%confidence interval 0.07–0.95), 0.334 vs size M (95% CI 0,16–0; 68), 0.408 vs size L (95% CI 0,21–0.81)] but equivalent risk of PPI rates for all other combination of valve sizes.

CONCLUSIONS
Su-AVR is associated with higher PPI rate as compared to SAVR. However, the increased PPI rate appears to be size-dependent with significant higher rate only for size XL. The combination of preoperative conduction disorder and a size XL can lead to a higher probability of early PPI in Su-AVR.

Clinical trial registration number
NCT02673697.
Comparison of a full sternotomy with a minimally invasive approach for concomitant mitral and tricuspid valve surgery
Authors: Paparella Domenico , Margari Vito , Santarpino Giuseppe , Moscarelli Marco , Guida Pietro , Fattouch Khalil , Albertini Alberto , Martinelli Luigi , Mikus Elisa , Gregorini Renato , Speziale Giuseppe 
Published: February 2022

AbstractOBJECTIVESThe need for concomitant tricuspid surgery in patients who need mitral valve surgery casts doubt on its feasibility via a minimally invasive approach. Our goal was to evaluate the short-term outcomes of patients undergoing concomitant mitral and tricuspid valve surgery either with a standard full sternotomy (full-MTS) or a minimally invasive approach (mini-MTS).METHODSThe outcomes of patients who had combined mitral and tricuspid valve surgery in 11 centres were retrospectively evaluated. The primary outcome was the incidence of 30-day mortality. A propensity score matched cohort was selected to create 2 comparable groups stratified by surgery (valve replacement or repair).RESULTSDuring the study period, 1048 consecutive patients had combined mitral and tricuspid valve surgery (730 full-MTS, 318 mini-MTS). The matching procedure paired 192 full-MTS to 192 mini-MTS procedures. After matching, mini-MTS was associated with longer cardiopulmonary bypass [123 min, standard deviation (SD) 46, vs 102 min, SD 36, P = 0.001] and cross-clamping times (89 min, SD 34, vs 78 min, SD 29, P = 0.003). Although the hospital length of stay was shorter (8 days, interquartile range 7-12 vs 9 days, interquartile range 7–14, P = 0.034) with mini-MTS before matching, this difference disappeared after matching. No differences in other major complications or in 30-day mortality were observed: 48 deaths (4.6%), 36 of which (4.9%) occurred in patients who had a full-MTS and 12 (3.8%), in patients who had a mini-MTS (4.7% in both approaches paired by propensity).CONCLUSIONSThe mini-MTS approach proved to be safe and effective in patients requiring concomitant mitral and tricuspid surgery. We could not demonstrate any difference in short-term outcomes between the 2 surgical approaches, indicating that there is not a preferred surgical approach.
Cardiac ablation with pulsed electric fields: principles and biophysics
Authors: Sugrue Alan , Maor Elad , Del-Carpio Munoz Freddy , Killu Ammar M , Asirvatham Samuel J 
Published: February 2022

Abstract
Pulsed electric fields (PEFs) have emerged as an ideal cardiac ablation modality. At present numerous clinical trials in humans are exploring PEF as an ablation strategy for both atrial and ventricular arrhythmias, with early data showing significant promise. As this is a relatively new technology there is limited understanding of its principles and biophysics. Importantly, PEF biophysics and principles are starkly different to current energy modalities (radiofrequency and cryoballoon). Given the relatively novel nature of PEFs, this review aims to provide an understanding of the principles and biophysics of PEF ablation. The goal is to enhance academic research and ultimately enable optimization of ablation parameters to maximize procedure success and minimize risk.
Rewiring host–microbe interactions and barrier function during gastrointestinal inflammation
Authors: Jensen Sune K , Pærregaard Simone I , Brandum Emma P , Jørgensen Astrid S , Hjortø Gertrud M , Jensen Benjamin A H 
Published: February 2022

Abstract
Organismal survival depends on a well-balanced immune system and maintenance of host–microbe mutualism. The fine-tuned relationship between the gut microbiota and host immunity is constantly challenged by opportunistic bacteria testing the integrity of gastrointestinal (GI) barrier defenses. Barrier dysfunction reduces immunological tolerance towards otherwise innocuous microbes; it is a process that may instigate chronic inflammation. Paradoxically, sustained inflammation further diminishes barrier function, enabling bacterial translocation to extra-intestinal tissues. Once translocated, these bacteria stimulate systemic inflammation, thereby compromising organ function. While genetic risk alleles associate with barrier dysfunction, environmental stressors are key triggers of GI inflammation and associated breakdown in immune tolerance towards resident gut microbes. As dietary components dictate substrate availability, they also orchestrate microbiota composition and function, including migratory and pro-inflammatory potential, thus holding the capacity to fuel both GI and extra-intestinal inflammation. Additionally, Western diet consumption may weaken barrier defenses via curbed Paneth cell function and diminished host-defense peptide secretion. This review focuses on intervenable niches of host–microbe interactions and mucosal immunity with the ambition to provide a framework of plausible strategies to improve barrier function and regain tolerance in the inflamed mucosa via nutritional intervention.
How Sequence Context-Dependent Mutability Drives Mutation Rate Variation in the Genome
Authors: Oman Madeleine , Alam Aqsa , Ness Rob W 
Published: February 2022

Abstract
The rate of mutations varies &gt;100-fold across the genome, altering the rate of evolution, and susceptibility to genetic diseases. The strongest predictor of mutation rate is the sequence itself, varying 75-fold between trinucleotides. The fact that DNA sequence drives its own mutation rate raises a simple but important prediction; highly mutable sequences will mutate more frequently and eliminate themselves in favor of sequences with lower mutability, leading to a lower equilibrium mutation rate. However, purifying selection constrains changes in mutable sequences, causing higher rates of mutation. We conduct a simulation using real human mutation data to test if 1) DNA evolves to a low equilibrium mutation rate and 2) purifying selection causes a higher equilibrium mutation rate in the genome’s most important regions. We explore how this simple process affects sequence evolution in the genome, and discuss the implications for modeling evolution and susceptibility to DNA damage.
The ‘becomings’: singing and songwriting with mothers and midwives at South-East Queensland
Authors: Mani Charulatha 
Published: February 2022

Plain language summary

How can songwriting show us the meaning of music and language for health and wellbeing in culturally and linguistically diverse mothers? This article examines the artistic processes in music-cum-health workshops involving new and expectant mothers and their midwives. The voices of the mothers of colour have been silenced historically and systemically. To give them social justice in a health context, singing is a powerful tool and songwriting links this tool to useful health messages. Through this article, the formation of a song on the placenta, a key part of the womb in childbearing, is traced through the stories of a music facilitator, a mother and a midwife. The storying highlights the importance of artistic processes for understanding the person within and their cultural identity. The article argues that cultural understanding of the participants in such arts-in-health programmes is important for socially just models of health care for those at the margins.

Summary
From being instrumentalized as interventions that are ‘administered’ with an aim to garner health outcomes, art-based participatory approaches are now recognized as capable of activating culturally founded wellbeing in individuals. Through this article, I propose that as the focus shifts from what art does for health to what art means for a healthy life, the cultural vitality inherent in individuals and societies can be better championed in arts-in-health discourses. I discuss the artistic processes in singing and songwriting in a perinatal context involving mothers from culturally and linguistically diverse backgrounds and their midwives. I argue for lenses to better understand the role of cultural practices in health research involving migrant and refugee communities. Using narrative inquiry, I trace intersecting trajectories wherein the storied life of a coloured mother is intercepted by that of a midwife, and of myself, a coloured female mother-researcher and facilitator. At the intersection emerges a song, as a process and product. This article advances that it is when artmaking processes are centred that the voices from the margins become heard, and it is when their voices are amplified that health research design becomes equitable and ethically sound.
Lower Impact of Disease on Daily Life and Less Fatigue in Patients With Inflammatory Bowel Disease Following a Lifestyle Intervention
Authors: Lamers Carlijn R , de Roos Nicole M , Heerink Henrike H , van de Worp-Kalter Linda A , Witteman Ben J M 
Published: February 2022

Abstract

Background
Despite the potential benefits of diet and physical activity, evidence for beneficial effects of a combined lifestyle intervention is lacking in patients with inflammatory bowel disease (IBD). Therefore, we assessed its effects on impact of disease on daily life, clinical disease activity, fatigue, and health-related quality of life (HRQoL) in patients with IBD.

Methods
A 6-month single-arm intervention study was performed in adult IBD patients in remission or with mildly active disease. Participants received personal dietary and physical activity advice from a dietician and a physiotherapist in 6 consults. At baseline and over time, questionnaires on diet quality, physical activity, and disease-related outcomes were completed and fecal calprotectin was determined. Data were analyzed by linear mixed models.

Results
During the intervention, diet quality significantly increased (P &lt; .001), but the level of physical activity remained the same. Over time, impact of the disease on daily life reduced (P = .009) and fatigue decreased (P = .001), while clinical disease activity, HRQoL, and fecal calprotectin did not change. Improvement in diet quality was significantly associated with a lower impact of disease on daily life (β = 0.09; 95% confidence interval [CI], 0.03 to 0.15; P = .003) and less fatigue (β = -0.13; 95% CI, -0.20 to -0.07; P &lt; .001) but not with clinical disease activity, HRQoL, and fecal calprotectin. No associations were found with physical activity.

Conclusions
This combined lifestyle intervention significantly improved diet quality, and this improvement was associated with a reduction in the impact of disease on daily life and fatigue in patients with IBD in remission or with mildly active disease.
Normal Sperm DNA Integrity in Patients With Inflammatory Bowel Disease on Ustekinumab Maintenance Therapy
Authors: Grosen Anne , Bellaguarda Emanuelle , Liljeqvist-Soltic Ingela , Mejlby Hansen Mette , Skytte Anne-Bine , Julsgaard Mette , Hanauer Stephen B , Kelsen Jens 
Published: February 2022

Lay Summary
We demonstrate that ustekinumab does not adversely affect semen quality or sex hormones in male patients. Ustekinumab is not detectable in semen and poses no risk to partners. Our observations support a recommendation to continue ustekinumab therapy in patients wishing to conceive.
Impact of transit-time flow measurement on early postoperative outcomes in total arterial coronary revascularization with internal thoracic arteries: a propensity score analysis on 910 patients
Authors: Laali Mojgan , Nardone Nathalie , Demondion Pierre , D'Alessandro Cosimo , Guedeney Paul , Barreda Eleodoro , Lebreton Guillaume , Leprince Pascal 
Published: February 2022

Abstract

OBJECTIVES
The aim of this study was to evaluate the impact of transit-time flow measurement (TTFM) on early postoperative outcomes in total arterial coronary revascularization.

METHODS
A single-centre retrospective analysis was conducted on 910 patients undergoing isolated total arterial coronary artery bypass grafting with internal thoracic arteries (ITAs) at our institution, between January 2017 and February 2020. Complete arterial revascularization with bilateral ITAs with a Y-configuration, or single ITA, was planned for all patients. According to the surgeon preference, TTFM was assessed in 430 patients (TTFM group). They were compared with 480 patients without TTFM assessment (no TTFM group). Primary end point was the occurrence of in-hospital major cardiac adverse events (MACE). A propensity score analysis with an inverse probability weighting approach was performed to control for selection bias.

RESULTS
TTFM was associated with longer cardiopulmonary bypass times (76.0 [62.0; 91.2] vs 79.0 [65.0; 94.0] min, P = 0.042). Six (1.4%) patients in the TTFM group versus no patient in the no TTFM group underwent intraoperative graft revision because of unsatisfying flow values (P = 0.011). MACE were significantly lower in the TTFM group (14, 3.3%) than in the no TTFM group (33, 6.9%, P = 0.014). At crude regression, TTFM was protective against MACE occurrence (odds ratios 0.46, 95% confidence interval 0.23–0.85, P = 0.016). Inverse probability weighting adjustment did not significantly displace P-values and odds ratios for MACE occurrence in the TTFM group 0.44, 95% confidence interval 0.28–0.69, P &lt; 0.001.

CONCLUSIONS
Even if associated with longer cardiopulmonary bypass times, intraoperative graft flow measurement with TTFM reduces MACE occurrence and it should be recommended for graft evaluation in arterial coronary artery bypass grafting surgery.
Informing training needs for the revised certified clinical data manager (CCDMTM) exam: analysis of results from the previous exam
Authors: Williams Tremaine Brueon , Schmidtke Carsten , Roessger Kevin , Dieffenderfer Vicki , Garza Maryam , Zozus Meredith 
Published: February 2022

Abstract

Objective
To inform training needs for the revised Certified Clinical Data Manager (CCDMTM) Exam.

Introduction
Clinical data managers hold the responsibility for processing the data on which research conclusions and regulatory decisions are based, highlighting the importance of applying effective data management practices. The use of practice standards such as the Good Clinical Data Management Practices increases confidence in data, emphasizing that the study conclusions likely hold much more weight when utilizing standard practices.

Methods
A quantitative, descriptive study, and application of classic test theory was undertaken to analyze past data from the CCDMTM Exam to identify potential training needs. Data across 952 sequential exam attempts were pooled for analysis.

Results
Competency domain-level analysis identified training needs in 4 areas: design tasks; data processing tasks; programming tasks; and coordination and management tasks.

Conclusions
Analysis of past CCDMTM Exam results using classic test theory identified training needs reflective of exam takers. Training in the identified areas could benefit CCDMTM Exam takers and improve their ability to apply effective data management practices. While this may not be reflective of individual or organizational needs, recommendations for assessing individual and organizational training needs are provided.
Retracted: Increased feed supply and dietary fiber from sugar beet pulp improved energy retention in gestating sows
Authors: Wisbech Sigrid J , Bruun Thomas S , Theil Peter K 
Published: February 2022

Abstract
The aim of the study was to investigate whether increased inclusion of sugar beet pulp (SBP) alters retention of fat, protein, and energy when backfat (BF) is restored in early- and mid-gestation. In total, 46 sows were fed one of four treatments with increasing inclusion of SBP with dietary fiber (DF) levels of 119, 152, 185, and 217 g/kg; sows were assigned to one of three feeding strategies (FS; high, medium, and low) depending on BF thickness at mating and again at day 30 for the following month. On days 0, 30, 60, and 108, body weight (BW) and BF thickness were measured, and body pools of protein and fat were estimated using the deuterium technique. On days 30 and 60, urine, feces, and blood samples were collected to quantify metabolites, energy, and N balances. On days 15 and 45, heart rates were recorded to estimate the heat production. At farrowing, total born and weight of the litter were recorded. In early gestation, BW gain (P &lt; 0.01) and body protein retention increased (P &lt; 0.05) with increasing fiber inclusion, while body fat retention increased numerically by 59%. Increase in BF was the greatest for sows fed the high FS, intermediate when fed the medium strategy, and negligible for sows fed the lowest FS. N intake, N loss in feces, and N balance increased linearly, whereas N loss in urine tended to decrease with increasing inclusion of fibers in early gestation. Concomitantly, fecal energy output and energy lost as methane increased linearly (P &lt; 0.001), while energy output in urine declined linearly, and total metabolizable energy intake, therefore, increased from 40.5 MJ ME/d in the low-fiber group to 43.5 mega joule (MJ) metabolizable energy (ME)/d in the high-fiber group (P &lt; 0.001). Changing the metabolizable energy toward more ketogenic energy was expected to favor fat retention rather than protein retention. However, due to increased intake of metabolizable energy and increased N efficiency with increasing fiber inclusion, the sows gained more weight and protein with increasing fiber inclusion. In conclusion, increased feed intake improved both fat and protein retention, whereas increased DF concentration increased protein retention.
Maternal Body Mass Index, Diabetes, and Gestational Weight Gain and Risk for Pediatric Cancer in Offspring: A Systematic Review and Meta-Analysis
Authors: Marley Andrew R , Domingues Allison , Ghosh Taumoha , Turcotte Lucie M , Spector Logan G 
Published: February 2022

Abstract

Background
Pediatric cancer incidence has steadily increased concurrent with rising adult obesity, but associations between maternal obesity and associated comorbidities and pediatric cancer risk remain understudied. We aimed to quantitatively characterize associations of pediatric cancer risk with maternal prepregnancy body mass index (BMI), gestational weight gain, and maternal diabetes.

Methods
We performed a comprehensive and systematic literature search in Ovid and EMBASE from their inception to March 15, 2021. Eligible studies reported risk estimates and sample sizes and provided sufficient description of outcome and exposure ascertainment. Random effects models were used to estimate pooled effects.

Results
Thirty-four studies were included in the analysis. Prepregnancy BMI was positively associated with leukemia risk in offspring (odds ratio [OR] per 5-unit BMI increase =1.07, 95% confidence intervals [CI] = 1.04 to 1.11; I2 = 0.0%). Any maternal diabetes was positively associated with acute lymphoblastic leukemia risk (OR = 1.46, 95% CI = 1.28 to 1.67; I2 = 0.0%), even after restricting to birthweight-adjusted analyses (OR = 1.74, 95% CI = 1.29 to 2.34; I2 = 0.0%), and inversely associated with risk of central nervous system tumors (OR = 0.73, 95% CI = 0.55 to 0.97; I2 = 0.0%). Pregestational diabetes (OR = 1.57, 95% CI = 1.11 to 2.24; I2 = 26.8%) and gestational diabetes (OR = 1.40, 95% CI = 1.12 to 1.75; I2 = 0.0%) were also positively associated with acute lymphoblastic leukemia risk. No statistically significant associations were observed for gestational weight gain.

Conclusions
Maternal obesity and diabetes may be etiologically linked to pediatric cancer, particularly leukemia and central nervous system tumors. Our findings support weight management and glycemic control as important components of maternal and offspring health. Further validation is warranted.