bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Self-Adaptive Variant of CMSA: Application to the Minimum Positive Influence Dominating Set Problem
Authors: Akbay Mehmet Anıl , López Serrano Albert , Blum Christian 
Published: July 2022

AbstractConstruct, merge, solve and adapt (CMSA) is a recently developed, generic algorithm for combinatorial optimisation. Even though the usefulness of the algorithm has been demonstrated by applications to a range of combinatorial optimisation problems, in some applications, it was observed that the algorithm can be sensitive to parameter settings. In this work, we propose a self-adaptive variant of CMSA, called Adapt-CMSA, with the aim of reducing the parameter sensitivity of the original version of CMSA. The advantages of this new CMSA variant are demonstrated in the context of the application to the so-called minimum positive influence dominating set problem. It is shown that, in contrast to CMSA, Adapt-CMSA does not require a computation time intensive parameter tuning process for subsets of the considered set of problem instances. In fact, after tuning Adapt-CMSA only once for the whole set of benchmark instances, the algorithm already obtains state-of-the-art results. Nevertheless, note that the main objective of this paper is not the tackled problem but the improvement of CMSA.
p-adic Cellular Neural Networks
Authors: Zambrano-Luna B. A. , Zúñiga-Galindo W. A. 
Published: July 2022

AbstractIn this article we introduce the p-adic cellular neural networks which are mathematical generalizations of the classical cellular neural networks (CNNs) introduced by Chua and Yang. The new networks have infinitely many cells which are organized hierarchically in rooted trees, and also they have infinitely many hidden layers. Intuitively, the p-adic CNNs occur as limits of large hierarchical discrete CNNs. More precisely, the new networks can be very well approximated by hierarchical discrete CNNs. Mathematically speaking, each of the new networks is modeled by one integro-differential equation depending on several p-adic spatial variables and the time. We study the Cauchy problem associated to these integro-differential equations and also provide numerical methods for solving them.
Voltammetric determination of acetaminophen in pharmaceutical preparations and human urine using glassy carbon paste electrode modified with reduced graphene oxide
Authors: Farag Amir Shaaban 
Published: July 2022

AbstractA completely new direct voltammetric method has been developed for determination of acetaminophen (APAP), known as popular analgesic drug. The present electroanalytical method is based on anodic oxidation of APAP at the glassy carbon paste electrode modified with reduced graphene oxide (RGO). Key experimental conditions were studied, resulting in a set of optimal conditions: acetate buffer (pH 5.0) as working medium electrolyte, content of RGO, parameters of squarewave voltammetry including the potential step of 5 mV, potential amplitude of 50 mV, and frequency of 40 Hz. If peak area is used for evaluation, a linear range from 1.2 × 10–6to 2.2 × 10–4 mol L−1characterized by determination coefficient of 0.9971, limits of quantification and detection, 9.3 × 10–7 mol L−1and 3.1 × 10–7 mol L−1, respectively, will be obtained. Under validation, the precision was described by relative standard deviation of 2.9% for the model sample analysis. Finally, the developed voltammetric method was compared with a reference high-performance liquid chromatography method in the analysis of commercially available pharmaceutical preparation and human urine collected from five healthy volunteers.Graphical abstract
The Deep Ocean's Carbon Exhaust
Authors: Chen Haidi , Haumann F. Alexander , Talley Lynne D. , Johnson Kenneth S. , Sarmiento Jorge L. 
Published: July 2022

AbstractThe deep ocean releases large amounts of old, pre‐industrial carbon dioxide (CO2) to the atmosphere through upwelling in the Southern Ocean, which counters the marine carbon uptake occurring elsewhere. This Southern Ocean CO2 release is relevant to the global climate because its changes could alter atmospheric CO2 levels on long time scales, and also affects the present‐day potential of the Southern Ocean to take up anthropogenic CO2. Here, year‐round profiling float measurements show that this CO2 release arises from a zonal band of upwelling waters between the Subantarctic Front and wintertime sea‐ice edge. This band of high CO2 subsurface water coincides with the outcropping of the 27.8 kg m−3 isoneutral density surface that characterizes Indo‐Pacific Deep Water (IPDW). It has a potential partial pressure of CO2 exceeding current atmospheric CO2 levels (∆PCO2) by 175 ± 32 μatm. Ship‐based measurements reveal that IPDW exhibits a distinct ∆PCO2 maximum in the ocean, which is set by remineralization of organic carbon and originates from the northern Pacific and Indian Ocean basins. Below this IPDW layer, the carbon content increases downwards, whereas ∆PCO2 decreases. Most of this vertical ∆PCO2 decline results from decreasing temperatures and increasing alkalinity due to an increased fraction of calcium carbonate dissolution. These two factors limit the CO2 outgassing from the high‐carbon content deep waters on more southerly surface outcrops. Our results imply that the response of Southern Ocean CO2 fluxes to possible future changes in upwelling are sensitive to the subsurface carbon chemistry set by the vertical remineralization and dissolution profiles.
Evolution of the Atlantic Intertropical Convergence Zone, and the South American and African Monsoons Over the Past 95‐Myr and Their Impact on the Tropical Rainforests
Authors: Acosta R. Paul , Ladant Jean‐Baptiste , Zhu Jiang , Poulsen Christopher J. 
Published: July 2022

AbstractThe widening of the South Atlantic Basin led to the reorganization of regional atmospheric and oceanic circulations. However, the response of the Atlantic Intertropical Convergence Zone (ITCZ), and South American and African monsoons across paleoclimate states, especially under constant paleogeographic and climatic changes, has not been well understood. Here we report on paleoclimate simulations of the Cenomanian (∼95 Ma), early Eocene (∼55 Ma), and middle Miocene (∼14 Ma) using the Community Earth System Model version 1.2 to understand how the migration of the South American and African continents to their modern‐day positions, uplift of the Andes and East African Rift Zone, and the decline of atmospheric CO2 changed the Atlantic ITCZ, and the South American and African monsoons and rainforests. Our work demonstrates that the South Atlantic widening developed the Atlantic ITCZ. The South Atlantic widening and Andean orogeny led to a stronger South American monsoon. We find the orogeny of the East African Rift Zone is the primary mechanism that strengthened the East African monsoon, whereas the West African monsoon became weaker through time as West Africa migrated toward the subtropics and CO2 levels fell below 500 ppm. We utilize the Köppen‐Geiger Climate Classification as an indicator for maximum rainforest extent. We find that during the Cenomanian and early Eocene, a Pan‐African rainforest existed, while the Amazon rainforest was restricted toward the northwestern corner of South America. During the middle Miocene, the Pan‐African rainforest was reduced to near its modern‐day size, while the Amazon rainforest expanded eastward.
Spaceborne Evidence That Ice‐Nucleating Particles Influence High‐Latitude Cloud Phase
Authors: Carlsen Tim , David Robert O. 
Published: July 2022

AbstractMixed‐phase clouds (MPCs), which consist of both supercooled cloud droplets and ice crystals, play an important role in the Earth's radiative energy budget and hydrological cycle. In particular, the fraction of ice crystals in MPCs determines their radiative effects, precipitation formation and lifetime. In order for ice crystals to form in MPCs, ice‐nucleating particles (INPs) are required. However, a large‐scale relationship between INPs and ice initiation in clouds has yet to be observed. By analyzing satellite observations of the typical transition temperature (T*) where MPCs become more frequent than liquid clouds, we constrain the importance of INPs in MPC formation. We find that over the Arctic and Southern Ocean, snow and sea ice cover significantly reduces T*. This indicates that the availability of INPs is essential in controlling cloud phase evolution and that local sources of INPs in the high‐latitudes play a key role in the formation of MPCs.
Characteristics of Fault Rocks Within the Aftershock Cloud of the 2014 Orkney Earthquake (M5.5) Beneath the Moab Khotsong Gold Mine, South Africa
Authors: Miyamoto T. , Hirono T. , Yokoyama Y. , Kaneki S. , Yamamoto Y. , Ishikawa T. , Tsuchiyama A. , Katayama I. , Yabe Y. , Ziegler M. , Durrheim R. J. , Ogasawara H. 
Published: July 2022

AbstractCores recovered during the International Continental Scientific Drilling Program project “Drilling into Seismogenic zones of M2.0 to M5.5 earthquakes in deep South African Gold Mines” include fault breccia from within the aftershock cloud of the 2014 Orkney earthquake (M5.5). The breccia and surrounding intrusive rocks, probably lamprophyres rich in talc, biotite, calcite, and amphibole, had high magnetic susceptibilities owing to the presence of magnetite. All of these characteristics can be attributed to fluid‐related alteration. Both the breccia and the lamprophyres had low friction coefficients and showed evidence of velocity strengthening, which is inconsistent with the occurrence of earthquakes. Variable amounts of talc, biotite, calcite, and amphibole within the lamprophyres might have produced complex frictional properties and spatial heterogeneity of fault stability. The altered lamprophyres may be the host rocks of the 2014 Orkney earthquake, but frictional complexity may have governed the magnitudes of the main‐ and aftershocks and their distributions.
Investigating the Occurrence of Magnetic Reconnection at Jupiter's Dawn Magnetopause During the Juno Era
Authors: Montgomery J. , Ebert R. W. , Clark G. , Fuselier S. A. , Allegrini F. , Bagenal F. , Bolton S. J. , DiBraccio G. A. , Wilson R. J. 
Published: July 2022

AbstractIn this study, observations from the Jovian auroral distributions experiment, Jupiter energetic particle detector instrument, and Magnetic field investigation instruments on Juno are used to identify signatures of magnetic reconnection at Jupiter's dawn magnetopause and relate these signatures to the local plasma environment. Magnetopause crossings occurred between 73–114 Jovian radii and 4.3–6.2 magnetic local time at low latitudes. Reconnection signatures include plasma energization and ion velocity enhancements resembling reconnection jets. We test for diamagnetic suppression which considers the magnetic shear and plasma beta (β) before and after a magnetopause crossing. Findings show that a large majority of these dawn magnetopause crossings at Jupiter have a low likelihood for local magnetic reconnection (are diamagnetically suppressed) because of high delta β values and/or low magnetic shear angles across the magnetopause boundary. These crossings exhibit no evidence of local reconnection while crossings that are not diamagnetically suppressed show multiple signatures of reconnection, adhering to the Swisdak relation.
Thermal and Illumination Environments of Lunar Pits and Caves: Models and Observations From the Diviner Lunar Radiometer Experiment
Authors: Horvath Tyler , Hayne Paul O. , Paige David A. 
Published: July 2022

AbstractLunar collapse pits may provide access to subsurface lava tubes of unknown extent. We present Diviner Lunar Radiometer measurements showing that the Mare Tranquillitatis and Mare Ingenii pits exhibit elevated thermal emission during the night, ∼100 K warmer than the surrounding surface. Using these data, along with computational thermophysical models, we characterize the thermal environment inside pits and potential caves. Near the equator, peak day‐time temperatures on regolith‐covered pit floors can potentially reach >420 K, whereas temperatures beyond the opening in permanent shadow would maintain a nearly constant temperature of ∼290 K, similar to that of a blackbody cavity in radiative equilibrium. Thermal IR measurements such as those of Diviner can readily detect pit thermal signatures but would be insensitive to the existence of caves they may host, as the latter would only induce a 0.1 K increase to night‐time temperatures of the overlying surface.
Quasi‐Periodic Whistler Mode Emission in the Plasmasphere as Observed by the DSX Spacecraft
Authors: Farrell W. M. , Lauben D. S. , Miller J. A. , Inan U. S. , Linscott I. R. , Galkin I. , Su Y.‐J. , Johnston W. R. , Starks M. J. , Sanchez J. C. , Ginet G. 
Published: July 2022

AbstractWe describe the quasi‐periodic (QP) whistler‐mode emissions found in the plasmasphere as detected by electric and magnetic instrumentation onboard the Demonstration and Science Experiments (DSX) spacecraft in medium Earth orbit. Over the course of the nearly 2‐year mission, at least 45 episodes of whistler mode QP emissions were detected by the Broad Band Receiver (BBR) onboard DSX. Episodes of QP emissions were identified by discrete events having a clear unambiguous periodic nature as detected by both the electric antennae and search coil magnetic sensors in the BBR survey data at 30 s temporal resolution. Most of the QP episodes occurred in a frequency range between 1 and 4 kHz, in a band previously identified by Van Allen Probes and Cluster investigators. However, episodes were also detected by DSX at higher frequencies ‐ events in these episodes extending all the way to 15 kHz. We present our findings on these unusual high frequency events in the presentation herein. Specifically, these high frequency QP episodes tended to be observed near dawn/dusk when the spacecraft was at relatively high magnetic latitudes and on magnetic L‐shells between 3 and 5. Another unusual feature of these episodes is that individual up‐drifting events making up the episode were found to sometimes occur concurrently in time: The high frequency portion of one up‐drifting “polliwog‐shaped” event overlapped in time with the low frequency portion of the subsequent event. This behavior of the QP emissions has not been previously emphasized and we consider how this temporal concurrence relates to the source processes.
Diurnal Coastal Trapped Waves and Associated Deep‐Ocean Mixing Near the Head of Suruga Trough
Authors: Nagai Taira , Hibiya Toshiyuki 
Published: July 2022

AbstractCoastal submarine canyons are expected to be sites of enhanced turbulent mixing which create productive fishing areas in coastal waters. Recent studies suggested the potential role of diurnal coastal trapped waves (CTWs) in inducing significant turbulent mixing in coastal submarine canyons poleward of 30° where the diurnal tide becomes subinertial. Nevertheless, the detailed physical processes responsible for the generation and dissipation of CTWs in such submarine canyons have hardly been investigated so far. In the present study, to investigate the turbulent mixing processes associated with diurnal CTWs in submarine canyons, we carry out high‐resolution (Δx, Δy = 1/240°) non‐hydrostatic three‐dimensional numerical experiments focusing on Suruga Bay located at the north end of Suruga Trough, Japan. The numerical experiments show that diurnal (subinertial) tidal currents over the Izu Ridge generate CTWs which propagate cyclonically along the coast of Suruga Bay. In the middle of Suruga Bay, bottom‐intensified flow due to the diurnal CTWs interacts with rough seafloor topography to excite upward propagating internal lee waves, which create mixing hotspots extending high above the seafloor. The resulting diurnal (subinertial) tidal energy dissipation in Suruga Bay is found to be much larger than that associated with semidiurnal (superinertial) internal tides. Furthermore, it is found that baroclinic energy flux based on a simple barotropic‐baroclinic decomposition severely underestimates the wave energy flux in areas with high CTW activity. These results strongly indicate that the existence of CTWs might be a key factor to clarify the dissipation/mixing processes in submarine canyons.
Methane and Carbon Dioxide Fluxes in a Temperate Tidal Salt Marsh: Comparisons Between Plot and Ecosystem Measurements
Authors: Hill Andrew C. , Vargas Rodrigo 
Published: July 2022

AbstractTidal wetlands are comprised of complex interdependent pathways where measurements of carbon exchange are often scale dependent. Common data collection methods (i.e., chambers and eddy covariance) are inherently constrained to different spatial and temporal scales which could generate biased information for applications of carbon accounting, identifying functional relationships and predicting future responses to climate change. Consequently, it is needed to systematically evaluate measurements derived from multiple approaches to identify differences and how techniques complement each other to reconcile interpretations. To accomplish this, we tested ecosystem‐scale eddy covariance with plot‐scale chamber measurements within a temperate salt marsh. We found good agreement (R2 = 0.71–0.95) when comparing measurements of CH4 emissions and CO2 exchange but this agreement was dependent upon canopy phenology with discrepancies mainly arising during senescence and dormancy phenophases. The environmental drivers for CH4 and CO2 fluxes were mostly preserved across different measurement techniques, but the number of drivers increases while their individual strength decreases at the ecosystem scale. Empirical upscaling models parameterized with chamber measurements overestimated annual net ecosystem exchange (NEE; 108%) and gross primary production (GPP; 12%) while underestimating ecosystem respiration (Reco; 14%) and CH4 emissions (69%) compared to eddy covariance measurements. Our results suggest that the environmental complexity of CH4 and CO2 fluxes in salt marshes may be underestimated by chamber‐based measurements, and highlights how different techniques are complementary while considering limitations at each level of measurement.
Clinical use of the mRNA urinary biomarker SelectMDx test for prostate cancer
Authors: Visser Wieke C. H. , de Jong Hans , Steyaert Sandra , Melchers Willem J. G. , Mulders Peter F. A. , Schalken Jack A. 
Published: July 2022

AbstractBackgroundMolecular biomarker tests are developed as diagnostic tools for prostate cancer (PCa) diagnosis. The SelectMDx (MDxHealth, Nijmegen, The Netherlands) test is a urinary-based biomarker test intended to be used to predict presence of high-grade PCa upon biopsy in men with elevated serum prostate-specific antigen (PSA) levels. Previous validation of the SelectMDx test revealed that 53% of the unnecessary biopsies (biopsies indicating no- or GG1 PCa) could be avoided using the SelectMDx test as a decision-tool to select men for prostate biopsy. The objective of this study is to examine the use of the commercially available SelectMDx test under routine, real-life practice.MethodsMen that underwent a SelectMDx test between May 2019 and December 2020 and that were originating from countries that perform the SelectMDx test on a regular basis were included in this study, resulting in 5157 cases from 10 European countries. Clinical parameters, urinary RNA scores, and test outcomes were compared between PSA groups, age groups, countries, and the validation cohort (described previously [4]) using the Mann–WhitneyUtest, Chi-Square test, Benjamini–Hochberg and Kruskal–Wallis tests.Results40.72% of the cases received a negative SelectMDx result. The test is also used in patients outside the intended-use population (PSA < 3 and >10 ng/mL). Clinical parameters (age, PSA density, DRE outcome) varied between patient population from individual countries and the validation cohort, resulting in differences in the potential number of saved biopsies using the test.ConclusionsThe potential number of reduced biopsies in clinical use was 40,72% using the SelectMDx test, assuming a negative SelectMDx test resulted in the decision not to biopsy the patient. This is higher compared to the validation cohort, which is explained by differences in patient population.
Expanding the phylogenetic distribution of cytochrome b-containing methanogenic archaea sheds light on the evolution of methanogenesis
Authors: Ou Ya-Fei , Dong Hong-Po , McIlroy Simon J , Crowe Sean A , Hallam Steven J , Han Ping , Kallmeyer Jens , Simister Rachel L , Vuillemin Aurele , Leu Andy O , Liu Zhanfei , Zheng Yan-Ling , Sun Qian-Li , Liu Min , Tyson Gene W , Hou Li-Jun 
Published: July 2022

Abstract
Methane produced by methanogenic archaea has an important influence on Earth’s changing climate. Methanogenic archaea are phylogenetically diverse and widespread in anoxic environments. These microorganisms can be divided into two subgroups based on whether or not they use b-type cytochromes for energy conservation. Methanogens with b-type cytochromes have a wider substrate range and higher growth yields than those without them. To date, methanogens with b-type cytochromes were found exclusively in the phylum “Ca. Halobacteriota” (formerly part of the phylum Euryarchaeota). Here, we present the discovery of metagenome-assembled genomes harboring methyl-coenzyme M reductase genes reconstructed from mesophilic anoxic sediments, together with the previously reported thermophilic “Ca. Methylarchaeum tengchongensis”, representing a novel archaeal order, designated the “Ca. Methylarchaeales”, of the phylum Thermoproteota (formerly the TACK superphylum). These microorganisms contain genes required for methyl-reducing methanogenesis and the Wood-Ljundahl pathway. Importantly, the genus “Ca. Methanotowutia” of the “Ca. Methylarchaeales” encode a cytochrome b-containing heterodisulfide reductase (HdrDE) and methanophenazine-reducing hydrogenase complex that have similar gene arrangements to those found in methanogenic Methanosarcinales. Our results indicate that members of the “Ca. Methylarchaeales” are methanogens with cytochromes and can conserve energy via membrane-bound electron transport chains. Phylogenetic and amalgamated likelihood estimation analyses indicate that methanogens with cytochrome b-containing electron transfer complexes likely evolved before diversification of Thermoproteota or “Ca. Halobacteriota” in the early Archean Eon. Surveys of public sequence databases suggest that members of the lineage are globally distributed in anoxic sediments and may be important players in the methane cycle.
Drosophila caspases as guardians of host-microbe interactions
Authors: Kietz Christa , Meinander Annika 
Published: July 2022

AbstractAn intact cell death machinery is not only crucial for successful embryonic development and tissue homeostasis, but participates also in the defence against pathogens and contributes to a balanced immune response. Centrally involved in the regulation of both cell death and inflammatory immune responses is the evolutionarily conserved family of cysteine proteases named caspases. The Drosophila melanogaster genome encodes for seven caspases, several of which display dual functions, participating in apoptotic signalling and beyond. Among the Drosophila caspases, the caspase-8 homologue Dredd has a well-characterised role in inflammatory signalling activated by bacterial infections, and functions as a driver of NF-κB-mediated immune responses. Regarding the other Drosophila caspases, studies focusing on tissue-specific immune signalling and host-microbe interactions have recently revealed immunoregulatory functions of the initiator caspase Dronc and the effector caspase Drice. The aim of this review is to give an overview of the signalling cascades involved in the Drosophila humoral innate immune response against pathogens and of their caspase-mediated regulation. Furthermore, the apoptotic role of caspases during antibacterial and antiviral immune activation will be discussed.