bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study to Assess the Awareness and Practices of Helmet Use among Two-Wheeler Riders in Delhi
Authors: Tirwa Milan , Joshi Poonam , Sinha Aditi P. , Dolma Yangchen , Singh Man 
Published: September 2022

Abstract
Objectives To assess the awareness and practice of two-wheeler riders regarding the helmet use, and to determine the association of awareness and practices with selected variables.
Setting and Design This article is a descriptive survey, which was completed at All India Institute of Medical Sciences (AIIMS) premises, New Delhi, India.
Materials and Methods The pretested and validated tools developed by researcher consisted of demographic sheet (8 items) along with structured awareness and practice questionnaire.
Results and Conclusions Maximum participants were male (71.06%) with majority riding for 8 years. As much as 48% of the sample population had accidents while driving. Only 2.9% of them reported to have sustained severe injury during these accidents. The mean awareness and practice score related to helmet use were 49.58 ± 6.019.75 ± 5.56. There was weak correlation between awareness and practice. Association of awareness and practices with selected variables could not be observed (p-value—0.4870). Although public awareness is present, but law needs to be more stringent. Accidents are fatal and it can happen anywhere and anytime, irrespective of long or short distance, and wearing of helmet can save a person from major injuries.
Nonmalignant Pleural Effusions
Authors: Porcel José M. 
Published: September 2022

AbstractAlthough the potential causes of nonmalignant pleural effusions are many, the management of a few, including complicated pleural infections and refractory heart failure and hepatic hydrothoraces, can be challenging and requires the assistance of interventional pulmonologists. A pragmatic approach to complicated parapneumonic effusions or empyemas is the insertion of a small-bore chest tube (e.g., 14–16 Fr) through which fibrinolytics (e.g., urokinase and alteplase) and DNase are administered in combination. Therapeutic thoracenteses are usually reserved for small to moderate effusions that are expected to be completely aspirated at a single time, whereas video-assisted thoracic surgery should be considered after failure of intrapleural enzyme therapy. Refractory cardiac and liver-induced pleural effusions portend a poor prognosis. In cases of heart failure–related effusions, therapeutic thoracentesis is the first-line palliative therapy. However, if it is frequently needed, an indwelling pleural catheter (IPC) is recommended. In patients with hepatic hydrothorax, repeated therapeutic thoracenteses are commonly performed while a multidisciplinary decision on the most appropriate definitive management is taken. The percutaneous creation of a portosystemic shunt may be used as a bridge to liver transplantation or as a potential definitive therapy in nontransplant candidates. In general, an IPC should be avoided because of the high risk of complications, particularly infections, that may jeopardize candidacy for liver transplantation. Even so, in noncandidates for liver transplant or surgical correction of diaphragmatic defects, IPC is a therapeutic option as valid as serial thoracenteses.
Mediastinal Staging with Endobronchial Ultrasound in Early-Stage Non—Small Cell Lung Cancer: Is It Necessary?
Authors: Husta Bryan C. , Kalchiem-Dekel Or , Beattie Jason A. , Yasufuku Kazuhiro 
Published: September 2022

AbstractHerein we examine the need for minimally invasive mediastinal staging for patients with early-stage non—small cell lung cancer (NSCLC) using endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Early NSCLC, stages 1 and 2, has a 5-year survival rate between 53 and 92%, whereas stages 3 and 4 have a 5-year survival of 36% and below. With more favorable outcomes in earlier stages, greater emphasis has been placed on identifying lung cancer earlier in its disease process. Accurate staging is crucial as it dictates both prognosis and therapy. Inaccurate staging can adversely impact surgical candidacy (if falsely “over-staged”) or lead to inadequate treatment (if “under-staged”). Clinical staging utilizes noninvasive methods to evaluate the anatomic extent of disease; however, it remains controversial whether mediastinal staging of early NSCLC with radiological exams alone is sufficient. EBUS-TBNA has altered the landscape of invasive mediastinal staging and is a crucial component to improving confidence in lung cancer staging, specifically in early NSCLC. Radiographic occult lymph node metastasis identified upon review of surgical resection specimens of early NSCLC may support the argument to perform EBUS-TBNA in all cases of early-stage disease. Other data suggest that EBUS-TBNA could be spared in cases of peripheral cT1aN0 and cT1bN0 for which surgical resection with lymph node dissection is planned. By reviewing reported EBUS-TBNA outcomes in patients with early NSCLC, we aim to emphasize the necessity of staging with EBUS in this population.
A Common CHAT Gene Mutation of Congenital Myasthenic Syndrome Found in Kadazandusun Children
Authors: Tan Khian Aun , Chew Hui Bein , Yacob Yusnita , Khoo Teik Beng 
Published: September 2022

AbstractCongenital myasthenic syndrome (CMS) is an uncommon inherited neuromuscular junction disease. The clinical presentation of this disorder is diverse. Typically patients with this disorder present with early-onset swallowing difficulty and apnea in infancy, fluctuating ocular palsies and fatigable proximal muscle weakness during childhood, and late-onset form involving progressive weakness in adulthood. Difficulty in performing neurophysiology studies in children and the absence of a pathognomonic investigation marker increase the challenges in diagnosis of this disorder. The emergence of next-generation sequencing technology has circumvented these challenges somewhat, and has contributed to the discovery of novel mutations. We present here diagnostic odyssey of three CMS patients from two unrelated Kadazandusun kinships and their follow-up treatment. A rare homozygous mutation c.916G > C (p.Val306Leu) in CHAT gene was found in two siblings born of a consanguineous marriage. Third patient had compound heterozygous mutations c.406G > A (p.Val136Met) and c.916G > C (p.Val306Leu) in CHAT gene. We postulate that p.Val306Leu may be a founder mutation in the Kadazandusuns, an indigenous ethnic minority of Borneo Island.
A Retrospective Analysis of Retinopathy of Prematurity (ROP) in a Tertiary Newborn Intensive Care Unit: Incidence and Risk Factors of ROP
Authors: Varol Fatih , Ogreten Tulin , Ozdogan Tutku , Cömert Serdar , Samancı Nedim 
Published: September 2022

Abstract
Background Retinopathy of prematurity (ROP) is the most frequent problem which causes blindness in preterm babies. In our study we evaluate the frequency of retinopathy, the risk factors, and their effects on disease development in premature newborns admitted to our neonatal intensive care unit (NICU).
Methods A total of 139 premature infants with gestational ages less than 34 weeks followed in our NICU between January 1, 2008 and January 1, 2011. The infants were divided into two groups as group 1 (no ROP/mild ROP) and as group 2 (severe ROP).
Results The demographics of 139 patients were as follows: 79 (56.83%) were female and 60 (43.17%) were male. Overall, 104 (74.8%) patients were found to have no or mild ROP and 35 (25.2%) had severe ROP. Among the patients in the severe ROP group, 25 of them had plus disease. With logistic regression analysis, lower gestational age (odds ratio [OR]: 4.1, confidence interval [CI]: 1.9–9.2), the central catheter usage (OR: 13.4, CI: 1.2–146.6), hypotension (OR: 7.5, CI: 1.1–49.6), perinatal asphyxia (OR: 261.3, CI: 8.8–7725.4), apnea (OR: 18.1, CI: 1.6–202.6), and high FiO2 (OR: 1.2 CI: 1.0–1.5) were found to be related to severe ROP.
Conclusion Among the preterms with very low body weight included in our study, we found that the frequency of severe ROP requiring treatment was low. The most important factors related to severe ROP were found to be low gestational age and birth weight. Being aware of the risk factors related to severe ROP in addition to screening every preterm infant carrying these risk factors is extremely important for the early diagnosis and treatment to prevent blindness due to severe retinopathy.
Perspectives on Current Mechanical Ventilation Use and Training in Pediatric Critical Care Medicine Fellowship Programs in the United States
Authors: Malone Matthew P. , Bennett Erin , Irby Olivia Katherine , Pasala Sanjiv , Sanders Ronald C. , Spray Beverly J. , Dalabih Abdallah 
Published: September 2022

AbstractMechanical ventilation (MV) is an integral part of the care of the critically ill child, and contemporary MV includes a myriad of sophisticated modalities that should be tailored to specific disease pathology and severity. This requires Pediatric Critical Care Medicine (PCCM) physicians to have comprehensive training and experience with various modes. We sought to assess and describe the current landscape of MV practices and training from PCCM fellowship programs. To describe current MV practices and training in PCCM fellowship programs and assess the different modes of MV to which trainees are exposed, a piloted survey was sent to all 67 American PCCM fellowship program directors (PDs) in 2019. Forty-eight (71.6%) of PCCM PDs responded. Our survey shows that PCCM fellows are not uniformly exposed to the same MV modalities, and PDs' perception of fellows' competency in managing MV is variable. Our results suggest that there is a lack of exposure to the various modes of “conventional” MV, as well as inconsistent education about less-utilized “nonconventional” MV. Additionally, we found that PDs are aware of their fellows' limited exposure to various modalities, as many practice patterns are institution specific. This study identified gaps in MV education and training and advocates for PCCM fellowship programs to identify these deficiencies to equip all trainees with a solid knowledge base that will prepare them to utilize any mode of MV in their future practice.
Trigeminal Schwannoma: A Retrospective Analysis of Endoscopic Endonasal Management, Treatment Outcomes, and Neuropathic Sequelae
Authors: Patel Vijay A. , Polster Sean P. , Abou-Al-Shaar Hussam , Kalmar Christopher L. , Zenonos Georgios A. , Wang Eric W. , Gardner Paul A. , Snyderman Carl H. 
Published: September 2022

Abstract
Introduction Trigeminal schwannomas (TS) are rare skull base tumors that have been associated with significant neuropathic sequalae for patients. The authors aim to evaluate the clinical features, treatment outcomes, and neuropathic sequelae following endoscopic endonasal approach (EEA) for TS.
Methods The study involves a retrospective review of patients who underwent EEA for resection of TS at a single academic institution between 2004 and 2020. Radiographic and clinical data were recorded and analyzed.
Results A total of 16 patients were abstracted, with a mean age at the time of surgery of 44 years with a slight female (1.83:1) predominance. Primary preoperative symptomatology included facial pain/neuralgia (n = 5, 31.3%), facial hypoesthesia (n = 4, 25.0%), and headache (n = 4, 25.0%). Following TS resection, patients were found to have facial hypoesthesia (n = 11, 68.8%), neuropathic keratopathy (n = 4, 25.0%), and mastication musculature atrophy (n = 3, 18.8%). Patients with preoperative facial pain/neuralgia (n = 5, 31.3%) were significantly more likely to try adjunctive pain therapies (p = 0.018) as well as seek pain consultation (p = 0.018). Patients with preoperative migraines (n = 2, 12.5%) were significantly more likely to trial adjunctive pain therapies (p = 0.025) and undergo evaluation with pain specialists (p = 0.025). Finally, patients with preoperative pharmacologic agent utilization were significantly more likely to trial adjunctive pain therapies (p = 0.036) and pursue pain consultation (p = 0.036).
Conclusion Some degree of trigeminal dysfunction may be more common than previously reported following EEA for TS resection. Factors that appear to play a role in the development of trigeminal dysfunction include pre-existing pain syndromes such as facial pain/neuralgia or headache and preoperative medication utilization.
Neonatal Sotos Syndrome: A Novel Frameshift Mutation of the NSD1 Gene Associated with Neonatal Encephalopathy Presenting without Overgrowth
Authors: Singh Pari , Suryawanshi Pradeep , Garegrat Reema , Malshe Nandini 
Published: September 2022

AbstractSotos syndrome type I is one of the more common genetic overgrowth disorders. It presents classically with macrocephaly, distinctive facial gestalt, and acromegalic features, along with neonatal complications including hypotonia, feeding difficulties, and hypoglycemia with other minor feature inconstancies. The phenotypical overlap of features of this syndrome, more so in neonatal age, thwarts an easy diagnosis. In this case report, a neonate of a nonconsanguineous marriage to a multigravida mother with insignificant obstetric history, presented primarily with respiratory difficulty, central hypotonia, and hypoglycemia. Sparse hair, tall forehead, pointed chin, and lax skin were accompanied by persistent encephalopathy and refractory myoclonic jerks. However, the quintessential features of pre- and postnatal overgrowth were lacking, making the line of diagnosis difficult. On neuroimaging, atypical diffuse pachygyria was found. Clinical exome sequencing revealed heterozygous single base pair deletion in exon 21 of the NSD1 gene on chromosome 5q35, resulting in an unreported frameshift and premature truncation of the protein 19 amino acids downstream to codon 2065, confirming the genetic diagnosis of autosomal dominant Sotos syndrome 1. The neonate later succumbed to death after withdrawal of ventilatory support.
Coffin–Siris Syndrome in a Patient with Hirschsprung's Disease—Expanding the Phenotype by Mutation ARID1B: A Case Report and Literature Review
Authors: Freitas Leonardo F. , Ribeiro Lays S. , Duarte Márcio L. , Silva Mayara O. da , Ferreira Paula M. 
Published: September 2022

AbstractCoffin–Siris syndrome (CSS) is a rare syndrome with autosomal dominant inheritance, and it is characterized by intellectual disability, hypotonia, aplasia/hypoplasia of the distal phalanx of fifth fingernail, feeding difficulties, growth restriction, short stature, speech delay, hirsutism/hypertrichosis, and thinning hair on the scalp. Hearing impairment has also been described in some patients. In this article, we describe the case of a male patient diagnosed with CSS who, at 15 days of life, underwent surgery for megacolon correction and a later intestinal biopsy revealed the affected segment compatible with Hirschsprung's disease (HSCR). This patient was found to have a variant in ARID1B (p. [Pro934Glnfs*5]) in a component of the BAF complex which plays an important role in regulating the expression and differentiation. In addition, it mediates responses to environmental signals resulting from an ATP-dependent chromatin remodeling complex. This case added a unique clinical characteristics and a rare genetic variant in the repertoire of CSS.
Meme culture and suicide sensitivity: a quantitative study
Authors: Weiser Ryan , Alam Nafees 
Published: September 2022

AbstractPeople worldwide are bogged down with a multitude of issues, many of which may need some form of coping mechanism to counteract the negative beliefs that accompany those issues. For many, memes have become that coping mechanism. Looking at memes, the present study ascertained the effects that constant viewing of memes has on sensitivity when dealing with one of the most difficult concerns anyone can face, suicide. Using a pre-test/post-test design, participants (n = 51) were given a questionnaire to see how familiar they are with certain memes and to create a baseline for reactions to key phrases. The level of familiarity is broken down into three groups to understand the long-term effects of memes. The short-term effects were decided based on the intervention phase. During the intervention phase, the experimental group saw memes about suicide and depression, while the control group saw generally themed memes before the post-test was taken. Data is analyzed looking for a change between baseline and post-test results. The findings have shown that there are no long-term effects of memes which is a good sign, but there is a short-term effect and that is where the danger lies. Authors believed that findings would show a decrease in suicide sensitivity after participants view the suicide/depression-themed memes. In the end, the study found that the effects of memes are not long-term, but in fact only affect viewers for a limited time. Further research needs to be conducted in order to arrive at a more representative sample and subsequent conclusion.
Evidence that heat acclimation training may alter sleep and incidental activity
Authors: Osborne John O. , Minett Geoffrey M. , Stewart Ian B. , Trost Stewart , Drovandi Christopher , Costello Joseph T. , Pavey Toby G. , Borg David N. 
Published: September 2022

ABSTRACTThis randomized cross‐over study tested the hypothesis that heat acclimation training would detrimentally affect sleep variables and alter incidental physical activity compared to a thermoneutral training control condition. Eight recreationally trained males (V̇O2peak 49±4.9 mL.kg‐1.min‐1) completed two separate interventions separated by at least 31 days: 5 consecutive day training blocks of moderate‐intensity cycling (60 min·day‐1 at 50% peak power output) in a hot (34.9±0.7 °C and 53±4 % relative humidity) and a temperate (22.2±2.6 °C; 65±8 % relative humidity) environment. Wrist‐mounted accelerometers were worn continuously for the length of the training blocks and recorded physical activity, sleep quality and quantity. Data were analysed in a Bayesian framework, with the results presented as the posterior probability that a coefficient was greater or less than zero. Compared to the temperate training environment, heat acclimation impaired sleep efficiency (Pr β<0 = .979) and wake on sleep onset (Pr β>0 = .917). Daily sedentary time was, on average, 35 min longer (Pr β>0 = .973) and light physical activity time 18 min shorter (Pr β>0 = .960) during the heat acclimation period. No differences were observed between conditions in sleep duration, subjective sleep quality, or moderate or vigorous physical activity. These findings may suggest that athletes and coaches need to be cognisant that heat acclimation training may alter sleep quality and increase sedentary behaviour.
A false vacuum Skyrme model for nuclear matter
Authors: Ferreira L A , Livramento L R 
Published: September 2022

Abstract
The low energy regime of quantum chromodynamics (QCD) presents enormous challenges due to its large coupling. Effective field theories, like the Skyrme model, are useful approaches to study properties of strong interaction at hadronic scales. We propose a Skyrme-type model with a self-dual sector and that treats the density of the baryonic charge as a self-interacting fluid. The dynamics reduces to Coleman’s false vacuum problem for a scalar field that is a fractional power of that density. The main result is that such a Skyrme-type model is the first one to reproduce, with good accuracy, the experimental values of radii and binding energies for a very wide range of the mass number. The robust and simple properties of the model lead to many possible generalizations with implications not only in nuclear physics but also in other areas of physics.
Identification of radiopure tungsten for low background applications
Authors: Hakenmüller J , Maneschg W 
Published: September 2022

Abstract
In this article we explore the availability of radiopure tungsten and its potential as high density shield material for low background applications. For compact shield designs, conventionally, lead is used. Metallic tungsten and tungsten pseudo-alloys reach higher densities up to 19.3 g cm−3 and do not exhibit a significant 210Pb activity, which is a typical intrinsic contamination in lead. Within several γ-ray screening campaigns we were able to identify tungsten samples with activities similar or better than 1 mBq kg−1 in 232Th, 40K, 60Co and the second part of the 238U decay chain. In cooperation with a manufacturer we further reduced a persisting contamination in the first part of the 238U decay chain by a factor of ∼2.5 down to (305 ± 30) mBq kg−1. With Monte Carlo simulations, the construction of prototype tungsten-based setups and dedicated measurements, the shield capability of tungsten in comparison to lead was extensively studied. Specifically, the impact of cosmogenic radiation on the background at shallow depth was investigated. We showed that a 6%–40% reduction (depending on the exact shield configuration) in the muon-induced neutron fluence is achievable by replacing lead with an equivalent amount of tungsten regarding the suppression of external γ-radiation. Overall, many benefits using tungsten especially for low energy applications below a few 100 keV are found. The pseudo-tungsten alloy presented in this work paves the way for several applications especially regarding background suppression in particle and astroparticle physics search programs.
Role of vibrational properties and electron–phonon coupling on thermal transport across metal-dielectric interfaces with ultrathin metallic interlayers
Authors: Oommen Shany Mary , Fallarino Lorenzo , Heinze J , Hellwig Olav , Pisana Simone 
Published: September 2022

Abstract
We systematically analyze the influence of 5 nm thick metal interlayers inserted at the interface of several sets of different metal-dielectric systems to determine the parameters that most influence interface transport. Our results show that despite the similar Debye temperatures of Al2O3 and AlN substrates, the thermal boundary conductance measured for the Au/Al2O3 system with Ni and Cr interlayers is ∼2× and >3× higher than the corresponding Au/AlN system, respectively. We also show that for crystalline SiO2 (quartz) and Al2O3 substrates having highly dissimilar Debye temperature, the measured thermal boundary conductance between Al/Al2O3 and Al/SiO2 are similar in the presence of Ni and Cr interlayers. We suggest that comparing the maximum phonon frequency of the acoustic branches is a better parameter than the Debye temperature to predict the change in the thermal boundary conductance. We show that the electron–phonon coupling of the metallic interlayers also alters the heat transport pathways in a metal-dielectric system in a nontrivial way. Typically, interlayers with large electron–phonon coupling strength can increase the thermal boundary conductance by dragging electrons and phonons into equilibrium quickly. However, our results show that a Ta interlayer, having a high electron–phonon coupling, shows a low thermal boundary conductance due to the poor phonon frequency overlap with the top Al layer. Our experimental work can be interpreted in the context of diffuse mismatch theory and can guide the selection of materials for thermal interface engineering.