bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methadone prescribed as an analgesic by a specialist palliative medicine team in an acute hospital inpatient setting: retrospective study
Authors: Hayes Jennifer , Waldron Dympna , Levins Kirk J , Gaffney Laura , Azhar Mahrukh , Beatty Sharon , Mannion Eileen 
Published: September 2022

Emerging evidence suggests that methadone has a specific role in the management of treatment resistant cancer-related pain.ObjectivesTo investigate the utilisation pattern, safety and efficacy of methadone prescribed as an analgesic for the management of complex cancer-related pain in an acute hospital inpatient setting.MethodsA retrospective longitudinal observational study of patients prescribed methadone as an analgesic between April 2020 and July 2021 was performed.Changes in coprescribed baseline opioid, use of breakthrough opioid analgesic, patient rated pain scores and adverse side effects were analysed.Results16 patients with complex cancer-related treatment resistant pain who were prescribed methadone were included in the study. Of the 16 patients, 14 patients had metastatic disease. Pain was classified in 14 patients as mixed nociceptive-neuropathic and in 2 patients as neuropathic. 13 patients were coprescribed methadone with a pre-established opioid. Methadone was associated with a statistically significant decrease in both opioid breakthrough analgesic by 61%±28% (p<0.001), and coprescribed opioid by 17%±12% (p=0.015). Patient rated pain scores were also significantly decreased (p<0.001).ConclusionMethadone appears to have a specific role in the management of complex cancer pain, neuropathic pain, opioid-tolerance and opioid-induced hyperalgesia, which may be attributable to N-methyl-D-aspartate receptor antagonism.
Geological risk and uncertainty for underground storage of buoyant fluids, lessons learned in Illinois
Authors: Leetaru Hannes E. , Williams-Stroud Sherilyn , Freiburg Jared , McBride John , Whittaker Steve 
Published: September 2022

Abstract

This paper describes selected natural gas storage and carbon capture and storage (CCS) case studies from Illinois, USA, their general applicability to subsurface buoyant fluid storage, and summarizes lessons learned. In Illinois, a 70-year history of sustained natural gas storage has provided a foundational understanding of risk associated with using the subsurface for storing buoyant fluids. In addition to natural gas storage, over 3 million tonnes of CO
2
have been injected into the Cambrian Mt Simon Sandstone at the Decatur, IL CCS project site.

In Illinois, many of the storage projects are in the Mt Simon Sandstone, a saline (aquifer) reservoir. In gas storage fields the characterization of faulting and seal properties has historically not been adequate. Identification of Precambrian palaeotopography is essential when completing initial site assessment in reservoirs close to the Precambrian contact. The presence of basement palaeotopographical highs increases the risk of not having a storage reservoir and increased chance of induced seismicity.

The Cambrian Mt Simon Sandstone of the Illinois Basin has some of the most suitable strata in the midwestern USA for the sequestration of CO
2
and storage of energy in the form of natural gas. The improved understanding gained from natural gas storage and from carbon sequestration is also directly applicable to assessing the potential of emerging energy storage technologies, such as compressed air energy storage (CAES) and geological hydrogen storage.
HDAC5 Loss Enhances Phospholipid-Derived Arachidonic Acid Generation and Confers Sensitivity to cPLA2 Inhibition in Pancreatic Cancer
Authors: Pan Penglin , Qin Gengdu , Wang Bo , Yu Haixin , Chen Jie , Liu Jiaying , Bing Kaijian , Shen Jian , Ren Dianyun , Zhao Yuhan , Xia Wentao , Li Hui , Wu Heshui , Zhou Yingke 
Published: September 2022

Abstract

HDAC5 is a class IIa histone deacetylase member that is downregulated in multiple solid tumors, including pancreatic cancer, and loss of HDAC5 is associated with unfavorable prognosis. In this study, assessment of The Cancer Genome Atlas pancreatic adenocarcinoma dataset revealed that expression of HDAC5 correlates negatively with arachidonic acid (AA) metabolism, which has been implicated in inflammatory responses and cancer progression. Nontargeted metabolomics analysis revealed that HDAC5 knockdown resulted in a significant increase in AA and its downstream metabolites, such as eicosanoids and prostaglandins. HDAC5 negatively regulated the expression of the gene encoding calcium-dependent phospholipase A2 (cPLA2), the key enzyme in the production of AA from phospholipids. Mechanistically, HDAC5 repressed cPLA2 expression via deacetylation of GATA1. HDAC5 knockdown in cancer cells enhanced sensitivity to genetic or pharmacologic inhibition of cPLA2 in vitro and in vivo. Fatty acid supplementation in the diet reversed the sensitivity of HDAC5-deficient tumors to cPLA2 inhibition. These data indicate that HDAC5 loss in pancreatic cancer results in the hyperacetylation of GATA1, enabling the upregulation of cPLA2, which contributes to overproduction of AA. Dietary management plus cPLA2-targeted therapy could serve as a viable strategy for treating HDAC5-deficient pancreatic cancer patients.

Significance:
The HDAC5-GATA1-cPLA2-AA signaling axis regulates sensitivity to fat restriction plus cPLA2 inhibition in pancreatic ductal adenocarcinoma, proposing dietary management as a feasible strategy for treating a subset of patients with pancreatic cancer.
Impact of Socioeconomic Status on Mortality and Readmission in Patients With Heart Failure With Reduced Ejection Fraction: The ARIC Study
Authors: Mathews Lena , Ding Ning , Mok Yejin , Shin Jung‐Im , Crews Deidra C. , Rosamond Wayne D. , Newton Anna‐Kucharska , Chang Patricia P. , Ndumele Chiadi E. , Coresh Josef , Matsushita Kunihiro 
Published: September 2022

Background
Low socioeconomic status (SES) is associated with a higher risk of heart failure (HF). The contribution of individual and neighborhood SES to the prognosis and quality of care for HF with reduced ejection fraction is not clear yet has important implications.

Methods and Results

We examined 728 participants of the
ARIC
(Atherosclerosis Risk in Communities) study (mean age, 78.2 years; 34% Black participants; 46% women) hospitalized with HF with reduced ejection fraction (ejection fraction <50%) between 2005 and 2018. We assessed associations between education, income, and area deprivation index with mortality and HF readmission using multivariable Cox models. We also evaluated the use of guideline‐directed medical therapy (optimal: ≥3 of ß‐blockers, mineralocorticoid receptor antagonist, angiotensin‐converting enzyme inhibitors, or angiotensin receptor blockers; acceptable: at least 2) at discharge. During a median follow‐up of 3.2 years, 58.7% were readmitted with HF, and 74.0% died. Low income was associated with higher mortality (hazard ratio [HR], 1.52 [95% CI, 1.14–2.04]) and readmission (HR, 1.45 [95% CI, 1.04–2.03]). Similarly, low education was associated with mortality (HR, 1.27 [95% CI, 1.01–1.59]) and readmission (HR, 1.62 [95% CI, 1.24–2.12]). The highest versus lowest area deprivation index quartile was associated with readmission (HR, 1.69 [95% CI, 1.11–2.58]) but not necessarily with mortality. The prevalence of optimal guideline‐directed medical therapy and acceptable guideline‐directed medical therapy was 5.5% and 54.4%, respectively, but did not significantly differ by SES.

Conclusions
Among patients hospitalized with HF with reduced ejection fraction, low SES was independently associated with mortality and HF readmission. A targeted secondary prevention approach that focuses intensive efforts on patients with low SES will be necessary to improve outcomes of those with HF with reduced ejection fraction.
Patients With Larger Left Atrial Appendage Orifice Presented Worse Prognosis Contributed by Acute Heart Failure After Left Atrial Appendage Closure
Authors: Ren Zhongyuan , Zheng Yixing , Zhang Jingying , Yang Haotian , Wu Jiayu , Li Hailing , Guo Rong , Meng Weilun , Zhang Jun , Sun Hui , Xu Yawei , Zhao Dongdong 
Published: September 2022

Background
Left atrial appendage (LAA) closure (LAAC) could prevent stroke in patients with atrial fibrillation. However, LAAC may impair the compliance of the left atrium and result in poor prognosis. This study aimed to comparatively evaluate the prognosis of LAAC among patients with different sizes of LAA orifice.

Methods and Results

Three hundred two consecutive patients who underwent successful LAAC were included and divided into 4 groups based on LAA orifice size that was measured using transesophageal echocardiography. Clinical outcomes including thromboembolic events, major cardiocerebrovascular adverse events, and acute heart failure (AHF) were compared among 4 quartile groups and between propensity‐score matched groups of large and small LAAs. Through follow‐up of 39.6±8.4 months, survival of thromboembolic events was similar. Survival of major cardiocerebrovascular adverse events was significantly lower in the group with the largest LAA orifice (log‐rank
P
<0.001), including a higher incidence of AHF with New York Heart Association class III to IV (21.4%, log‐rank
P
=0.009). A large LAA orifice (by cutoff) could predict major cardiocerebrovascular adverse events (hazard ratio, 3.749 [95% CI, 2.074–6.779]) in most patients, except for subgroups of those aged <65 years, with paroxysmal atrial fibrillation, and/or with failed rhythm/rate control. Further compared with a propensity‐score matched small‐LAA group, the large‐LAA orifice group still presented worse survival of AHF with New York Heart Association class III to IV (log‐rank
P
=0.010).

Conclusions
Patients with a larger LAA orifice presented a worse prognosis after LAAC, including a higher incidence of AHF. A large LAA orifice could predict a post‐LAAC AHF event in most patients, except for young patients, patients with paroxysmal atrial fibrillation, and/or with failed rhythm/rate control.

Registration

URL:
clinicaltrials.gov
; Unique identifier: NCT04185142.
Intact Fibroblast Growth Factor 23 Regulates Chronic Kidney Disease–Induced Myocardial Fibrosis by Activating the Sonic Hedgehog Signaling Pathway
Authors: Li Lanlan , Gan Hua 
Published: September 2022

Background
Clinically, myocardial fibrosis is one of the most common complications caused by chronic kidney disease (CKD). However, the potential mechanisms of CKD‐induced myocardial fibrosis have not been clarified.

Methods and Results
In our in vivo study, a rat model of CKD with 5/6 nephrectomy was established. The CKD model was treated with the glioma 1 (Gli‐1) inhibitor GANT‐61, and myocardial fibrosis and serum intact fibroblast growth factor 23 levels were assessed 16 weeks after nephrectomy. Finally, we found that Gli‐1 and Smoothened in the Sonic Hedgehog (Shh) signaling pathway were activated and that collagen‐1 and collagen‐3, which constitute the fibrotic index, were expressed in CKD myocardial tissue. After administering the Gli‐1 inhibitor GANT‐61, the degree of myocardial fibrosis was reduced, and Gli‐1 expression was also inhibited. We also measured blood pressure, cardiac biomarkers, and other indicators in rats and performed hematoxylin‐eosin staining of myocardial tissue. Furthermore, in vitro studies showed that intact fibroblast growth factor 23 promoted cardiac fibroblast proliferation and transdifferentiation into myofibroblasts by activating the Shh signaling pathway, thereby promoting cardiac fibrosis, as manifested by increased expression of the Shh, Patch 1, and Gli‐1 mRNAs and Shh, Smoothened, and Gli‐1 proteins in the Shh signaling pathway. The protein and mRNA levels of other fibrosis indicators, such as α‐smooth muscle actin, which are also markers of transdifferentiation, collagen‐1, and collagen‐3, were increased.

Conclusions
On the basis of these results, intact fibroblast growth factor 23 promotes CKD‐induced myocardial fibrosis by activating the Shh signaling pathway.
Enriching the American Heart Association COVID‐19 Cardiovascular Disease Registry Through Linkage With External Data Sources: Rationale and Design
Authors: Oseran Andrew S. , Sun Tianyu , Wadhera Rishi K. , Dahabreh Issa J. , de Lemos James A. , Das Sandeep R. , Rutan Christine , Asnani Aarti H. , Yeh Robert W. , Kazi Dhruv S. 
Published: September 2022

Background
The AHA Registry (American Heart Association COVID‐19 Cardiovascular Disease Registry) captures detailed information on hospitalized patients with COVID‐19. The registry, however, does not capture information on social determinants of health or long‐term outcomes. Here we describe the linkage of the AHA Registry with external data sources, including fee‐for‐service (FFS) Medicare claims, to fill these gaps and assess the representativeness of linked registry patients to the broader Medicare FFS population hospitalized with COVID‐19.

Methods and Results
We linked AHA Registry records of adults ≥65 years from March 2020 to September 2021 with Medicare FFS claims using a deterministic linkage algorithm and with the American Hospital Association Annual Survey, Rural Urban Commuting Area codes, and the Social Vulnerability Index using hospital and geographic identifiers. We compared linked individuals with unlinked FFS beneficiaries hospitalized with COVID‐19 to assess the representativeness of the AHA Registry. A total of 10 010 (47.0%) records in the AHA Registry were successfully linked to FFS Medicare claims. Linked and unlinked FFS beneficiaries were similar with respect to mean age (78.1 versus 77.9, absolute standardized difference [ASD] 0.03); female sex (48.3% versus 50.2%, ASD 0.04); Black race (15.1% versus 12.0%, ASD 0.09); dual‐eligibility status (26.1% versus 23.2%, ASD 0.07); and comorbidity burden. Linked patients were more likely to live in the northeastern United States (35.7% versus 18.2%, ASD 0.40) and urban/metropolitan areas (83.9% versus 76.8%, ASD 0.18). There were also differences in hospital‐level characteristics between cohorts. However, in‐hospital outcomes were similar (mortality, 23.3% versus 20.1%, ASD 0.08; home discharge, 45.5% versus 50.7%, ASD 0.10; skilled nursing facility discharge, 24.4% versus 22.2%, ASD 0.05).

Conclusions
Linkage of the AHA Registry with external data sources such as Medicare FFS claims creates a unique and generalizable resource to evaluate long‐term health outcomes after COVID‐19 hospitalization.
The role of donor and receiver size in the response to public cues in Hart’s rivulus, Anablepsoides hartii
Authors: Groves Veronica , Elvidge Chris K. , Brown Grant E. 
Published: September 2022

Abstract
Aquatic prey use chemical alarm cues as public information sources to optimize behavioural decisions. Recent studies suggest that the contextual value of these cues is shaped by their source, the size of the donor relative to the receiver, and the size of the receiver itself. Here, we exposed Hart’s rivulus (Anablepsoides hartii) to conspecific or heterospecific alarm cues from donors that were either smaller or larger than the mean focal rivulus size. Smaller rivulus reduced foraging in response to conspecific and heterospecific cues, regardless of donor size. However, larger rivulus exhibited no reduction in foraging towards small conspecific cues and increased foraging towards small heterospecific cues. Additionally, while conspecific donors elicited strong predator avoidance, rivulus exhibited stronger responses to large vs. small heterospecific cues. Our results demonstrate that the value of alarm cues is shaped by the interacting effects of receiver size and the size and species of cue donors.
Literature Festivals
Authors: Sapiro Gisèle 
Published: September 2022

Abstract
Literary festivals have become authorities in the literary field, promoting works through the charismatic persona of their author, and operating a transfer of symbolic capital from the most famous ones to the newcomers. Some of these festivals are international, and thus play a role in the making of world authorship and of world literature. Based on a quantitative and qualitative study of thirty-eight international literary festivals, this paper focuses on the way international literary festivals reflect, even as they shape, the structure of the transnational literary field. International festivals tend to mirror the unequal conditions of access to world authorship and the power relations that structure the world market for translations. However, some of them develop strategies to counter these power relations. They are also more politicized, and try to construct a more diverse and inclusive transnational public sphere, where writers act as public intellectuals.
Small punch testing of Al-TiB2 composites fabricated by spark plasma sintering: A computational and experimental study
Authors: Priel E , Mittelman B , Trabelsi N , Lulu-Bitton N , Haroush S , Kalabukhov S , Hayun S , Navi NU 
Published: September 2022

The Small Punch Test (SPT) method is especially useful for quantifying the mechanical properties of metallic materials in cases where the material available for testing is limited or for in service monitoring. However, the applicability of this method to metal matrix composites has not yet been fully established. In the present study, Al-TiB2 composite billets with TiB2 particle volume fractions of 5%,10% and 15% were manufactured using Spark Plasma Sintering (SPS). Thin specimens with 0.5 mm thickness were cut from the billets, and SPT experiments were conducted until failure. Well-accepted analytical techniques were utilized to determine the Al-TiB2 composite effective yield stress for all TiB2 particle volume fractions. It was shown, that standard analytical methods for characterizing the effective yield stress were adequate only for TiB2 volume fractions of up to 5%. The experimental mechanical response up to and including failure was reproduced for all Al-TiB2 compositions by finite element analysis incorporating a continuum damage mechanics approach. The computational analysis revealed that for high TiB2 volume content, the region of the SPT loading curve which is commonly associated with specimen yielding, may represent a mixture of yielded and damaged areas. Since the damage distribution in the specimen influences the specimen flexural modulus, standard analytical relations cannot be used to determine the composite yield stress and computational methods must be used. This finding may explain the inconsistent results reported in the literature with regard to the accuracy of the SPT method in determining the effective yield stress for metal matrix composites.
Capital budgeting and Kelly betting
Authors: Johnstone David J 
Published: September 2022

Capital investments are easily interpreted as bets and vice versa. The mathematical theory of betting, often known as ‘Kelly betting’, has implications for all financial decision-making under uncertainty. There have been attempts to exploit Kelly betting methods in financial portfolio optimization, but there has been little analysis of conventional capital budgeting methods against a Kelly framework. A simple comparison between methods reveals that capital budgeting decisions made using conventional finance methods can embed the error that Kelly theorists call ‘overbetting’. The outcome of overbetting is that the firm reduces its expected compound capital growth rate while simultaneously adding to the volatility of its anticipated growth path. That unfortunate pairing is mathematically precluded under Kelly betting rules but is implicitly, albeit unknowingly, sanctioned by accepted capital budgeting practices in finance.JEL Classification: G11, G12, G31
Addressing Stigma and Promoting Help-Seeking Among African Nova Scotian Youth Experiencing Psychosis and Other Mental Health Problems
Authors: Waldron Ingrid , Senger Brannon , Cookey Jacob , Crown Margie , Tibbo Phil 
Published: September 2022

Objectives The purpose of this study was to gain an in-depth understanding of perceptions of mental illnesses (especially psychosis), help-seeking, barriers to help-seeking, and opportunities to facilitate help-seeking in the African Nova Scotian Community. Methods A qualitative interpretive narrative approach, using the focus group method, was employed to engage African Nova Scotians in discussions on their perceptions and beliefs about mental illnesses and help-seeking in their communities. Youth in Early Intervention services, their caregivers, youth in the community, their caregivers, community leaders, and health service providers, were recruited from four locations in the Halifax Regional Municipality. A total of 75 individuals (37 female, 38 male) participated in the study. Narrative emplotment was used to analyse data from focus groups. Results Findings from focus groups were categorized based on four areas of discussion: (a) perceptions about psychosis and other mental illnesses among youth, caregivers, service providers and community leaders (b) beliefs about help-seeking among youth, caregivers, services providers and community leaders; (c) barriers and facilitators to seeking help for mental illnesses; and (d) the content and format of educational resources to educate and support youth, families and communities. Conclusions Stigma surrounding mental illnesses in the community, lack of knowledge of illness and available services, concerns regarding negative involvement with police, or dismissal of difficulties by health care providers represent significant barriers to help-seeking in this community. Additionally, barriers include a lack of trust in health care services and a dearth of African Nova Scotian service providers. Bolstering capacity of community organizations to support and educate individuals around illness as well as fostering collaboration between health services and community organizations could reduce barriers to care. Future research should focus on examining ways to engage African Nova Scotians in collaboration with existing community organizations.
Microwave assisted preparation of a hemostatic gauze with mesoporous silica through in-situ synthesis
Authors: Zhang Zhuoran , Hou Min , Liu Tao , Li Fan , Yang Kun , Ding Sheng , Lin Song 
Published: September 2022

The medical disinfection cotton gauze is the most frequently used medical consumables for wound care. Here this ordinary commercial gauze was upgraded to a hemostatic gauze, which was loaded with mesoporous silica through in-situ synthesis and further microwave treatment. The original cotton gauze was pretreated with NaOH solutions for surface activation, soaked in double-silica source precursor solution for moderate in-situ synthesis, treated with microwave for quick template removement and dehydration. The final obtained hemostatic gauze (MS-G1) showed superior physical, biocompatible and hemostatic advantages. The newborn mesoporous silica was firmly anchored onto the cotton fiber surface with <20% leaching after 10 min of sonication. The microwave treatment not only shortened the time for template removal but also promotes the formation of mesoporous structure. The clotting blood time (CBT) of MS-G1 were only (62.00 ± 5.56 s), which was 23.14% shorter than that of original medical gauze, and even 3.6% shorter than Combat Gauze (CG). MS-G1 also showed excellent biocompatibility in cytotoxicity tests of L-929 cells, with a 116% proliferation rate at the concentration of 5 mg/mL. Furthermore, the hemostatic performance was explored on a rabbit wound model of hemorrhagic liver injury, and MS-G1 showed both shorter hemostasis time (113.75 s) and less blood loss (1.69 g) than that of CG (180.00 s, 5.13 g). The hemostatic gauze anchored with mesoporous silica was expected to be an excellent prehospital hemostatic dressing for field first aid.