bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the pharmacological action mechanism of Ligusticum Chuanxiong-Piper Longum couplet medicines on the treatment of migraine based on network pharmacology
Authors: Li Ti , Guo Shupeng , Lu Meixi , Lu Fang , Lu Tianjiao , Zheng Chunze 
Published: September 2022

Objective: To study the mechanisms of the Ligusticum chuanxiong Hort.–Piper longum L. herbal pair (LPHP) in the treatment of migraine using network pharmacology.Methods: The active constituents of LPHP and their targets were searched for and screened using the Chinese Medicine System Pharmacology Database. Genes related to migraine were searched on GeneCards, Online Mendelian Inheritance in Man and other databases. Cytoscape was used to construct and combine active component–target and disease–target networks. The core target was screened by network topology analysis, and the Metascape database was used for gene ontology analysis of key targets and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis to explore the molecular mechanisms in the treatment of migraine.Results: A total of 28 active constituents of LPHP were obtained through database screening and literature review, and 60 cross-linking targets were obtained. The target sites were analysed using a protein–protein interaction network to obtain six target proteins with a greater degree of relevance. These were identified as the main targets for the treatment of hypertension, and these key targets were found to be associated with 20 signalling pathways, including neuroactive ligand–receptor interaction, the calcium signalling pathway, the cGMP–PKG signalling pathway, pathways in cancer and the cyclic adenosine 3′,5′-cyclic monophosphate (cAMP) signalling pathway.Conclusion: This study reveals the molecular mechanism of LPHP in the treatment of migraine from the perspective of network pharmacology and provides a basis for further research and molecular mechanism research.
Resistance training and Down Syndrome: A narrative review on considerations for exercise prescription and safety
Authors: Melo Geiziane Leite Rodrigues , Neto Ivo Vieira de Sousa , Fonseca Eduardo Fernandes da , Stone Whitley , Nascimento Dahan da Cunha 
Published: September 2022

The current manuscript reviews the literature on the health effects of resistance training (RT) for individuals with Down syndrome (DS), focusing on this training modality’s methodology, application, and safety. The literature has mentioned that early aging in this population is associated with loss of muscle strength, lower lean and bone mass, and increased obesity. It is necessary to propose non-pharmacological measures for prevention and health promotion. Thus, this review suggests a current research-based RT guide for individuals with DS. This review is divided into three sections: Section 2 briefly reviews DS and the effects on structural and functional decline and how exercise and physical activity can influence health aspects in this population; Section 3 summarizes the evidence for RT prescription; Section 4 briefly reviews the health and potential benefits of RT in individuals with DS. The findings from this review suggest that most individuals with DS should engage in moderate-intensity RT at least 2 days a week and perform RT on the major muscle groups and include balance training. The RT program should be modified and adapted according to individuals’ characteristics and limitations. RT promotes positive, health-related benefits such as increasing strength, improving body composition, improving functional capacity and balance, reducing inflammatory status and oxidative stress, and improving the immune system. The RT protocols summarized in this current review provide guidance, critical conclusions, and novel research settings, which could be useful to coaches, clinicians, and researchers to effectively design RT program for individuals with DS.
Meta-analysis of structural and functional brain abnormalities in schizophrenia with persistent negative symptoms using activation likelihood estimation
Authors: Zhu Tingting , Wang Zixu , Zhou Chao , Fang Xinyu , Huang Chengbing , Xie Chunming , Ge Honglin , Yan Zheng , Zhang Xiangrong , Chen Jiu 
Published: September 2022

BackgroundPersistent negative symptoms (PNS) include both primary and secondary negative symptoms that persist after adequate treatment, and represent an unmet therapeutic need. Published magnetic resonance imaging (MRI) evidence of structural and resting-state functional brain abnormalities in schizophrenia with PNS has been inconsistent. Thus, the purpose of this meta-analysis is to identify abnormalities in structural and functional brain regions in patients with PNS compared to healthy controls.MethodsWe systematically searched PubMed, Web of Science, and Embase for structural and functional imaging studies based on five research methods, including voxel-based morphometry (VBM), diffusion tensor imaging (DTI), functional connectivity (FC), the amplitude of low-frequency fluctuation or fractional amplitude of low-frequency fluctuation (ALFF/fALFF), and regional homogeneity (ReHo). Afterward, we conducted a coordinate-based meta-analysis by using the activation likelihood estimation algorithm.ResultsTwenty-five structural MRI studies and thirty-two functional MRI studies were included in the meta-analyses. Our analysis revealed the presence of structural alterations in patients with PNS in some brain regions including the bilateral insula, medial frontal gyrus, anterior cingulate gyrus, left amygdala, superior temporal gyrus, inferior frontal gyrus, cingulate gyrus and middle temporal gyrus, as well as functional differences in some brain regions including the bilateral precuneus, thalamus, left lentiform nucleus, posterior cingulate gyrus, medial frontal gyrus, and superior frontal gyrus.ConclusionOur study suggests that structural brain abnormalities are consistently located in the prefrontal, temporal, limbic and subcortical regions, and functional alterations are concentrated in the thalamo-cortical circuits and the default mode network (DMN). This study provides new insights for targeted treatment and intervention to delay further progression of negative symptoms.Systematic review registration[https://www.crd.york.ac.uk/prospero/], identifier [CRD42022338669].
Compliance level toward COVID-19 preventive measures and associated factors among the Ambo University community, 2021
Authors: Roga Ephrem Yohannes , Bekele Gemechu Gelan , Gonfa Dajane Negesse 
Published: September 2022

BackgroundThe coronavirus illness is a highly contagious viral infection with serious health consequences that has occurred all around the world. Application of COVID-19 prevention precautions and social interventions by the general public are critical to successfully combating the epidemic. Therefore, this study aimed to determine the level of compliance and associated factors with COVID-19 prevention strategies.MethodsA facility based cross-sectional study was conducted from June 01 to August 30, 2021 on a sample of 380 randomly selected Ambo University community members. A self-administered structuralized questionnaire was used to collect the data. The determining factors with the level of compliance were finally identified using a multivariate logistic regression model. The association was reported using odds ratios with a 95% CI, and significance was declared using a P &lt; 0.05.ResultsA total of 378 respondents participated in the study with a response rate of 98.9%. Most of the respondents, 75.7%, 57.9%, 47.4%, 61.9% had good knowledge, favorable attitude, good practice and good compliance toward COVID-19 preventive measures, respectively. In participants aged between 18 and 30 [AOR = AOR = 2.23, 95% CI: (1.13, 4.41)], good knowledge [AOR = 2.64, 95% CI: (1.46, 4.78)], favorable attitude [AOR = 4.5, 95% CI: (2.63, 7.71)], and good practice [AOR = 2.98, 95% CI: (1.82, 4.89)] were significantly associated with good compliance toward COVID-19 preventive measures.Conclusion and recommendationDespite the fact that COVID-19 is a global and national priority, the preventive measures were not sufficiently followed. Therefore, it is essential to continue working on the community's knowledge, practices, and attitude about COVID-19 preventive measures through media campaigns, which will ultimately increase compliance. Additionally, the concerned stakeholders should consider the required interventions for the strongly associated factors that have been discovered in this current study.
Comparison of COVID-19 and seasonal influenza under different intensities of non-pharmaceutical interventions and vaccine effectiveness
Authors: Chen Yinchang , Wang Zhende , Li Feng , Ma Jingyu , Zhang Jie , Chen Yunpeng , Zhang Ting 
Published: September 2022

BackgroundThe COVID-19 pandemic has lasted more than 2 years, and the global epidemic prevention and control situation remains challenging. Scientific decision-making is of great significance to people's production and life as well as the effectiveness of epidemic prevention and control. Therefore, it is all the more important to explore its patterns and put forward countermeasures for the pandemic of respiratory infections.MethodsModeling of epidemiological characteristics was conducted based on COVID-19 and influenza characteristics using improved transmission dynamics models to simulate the number of COVID-19 and influenza infections in different scenarios in a hypothetical city of 100,000 people. By comparing the infections of COVID-19 and influenza in different scenarios, the impact of the effectiveness of vaccination and non-pharmaceutical interventions (NPIs) on disease trends can be calculated. We have divided the NPIs into three levels according to the degree of restriction on social activities (including entertainment venues, conventions, offices, restaurants, public transport, etc.), with social controls becoming progressively stricter from level 1 to level 3.ResultsIn the simulated scenario where susceptible individuals were vaccinated with three doses of COVID-19 coronaVac vaccine, the peak number of severe cases was 26.57% lower than that in the unvaccinated scenario, and the peak number of infection cases was reduced by 10.16%. In the scenario with level three NPIs, the peak number of severe cases was reduced by 7.79% and 15.43%, and the peak number of infection cases was reduced by 12.67% and 28.28%, respectively, compared with the scenarios with NPIs intensity of level 2 and level 1. For the influenza, the peak number of severe cases in the scenario where the entire population were vaccinated was 89.85%, lower than that in the unvaccinated scenario, and the peak number of infections dropped by 79.89%.ConclusionThe effectiveness of COVID-19 coronaVac vaccine for preventing severe outcomes is better than preventing infection; for the prevention and control of influenza, we recommend influenza vaccination as a priority over strict NPIs in the long term.
Neoadjuvant Chemotherapy Versus Primary Debulking Surgery in FIGO Stage III and IV Epithelial Ovarian, Tubal or Peritoneal Cancer: A Systematic Review and Meta-Analysis
Authors: Tzanis Alexander A. , Iavazzo Christos , Hadjivasilis Alexandros , Tsouvali Hara , Antoniou George Α. , Antoniou Stavros A. 
Published: September 2022

Objective: To investigate whether neoadjuvant chemotherapy (NACT) confers superior outcomes compared to primary debulking surgery (PDS) in patients with stage III and IV epithelial ovarian, tubal or peritoneal cancer as well as in patients with high tumour load.Methods: We searched the electronic databases PubMed, Cochrane Central Register of Controlled trials, and Scopus from inception to March 2021. We considered randomised controlled trials (RCTs) comparing NACT with PDS for women with epithelial ovarian cancer (EOC) stages III and IV. The primary outcomes were overall survival and progression-free survival. Secondary outcomes were optimal cytoreduction rates, peri-operative adverse events, and quality of life.Results: Six RCTs with a total of 1901 participants were included. Meta-analysis demonstrated similar overall survival (HR = 0.96, 95% CI [0.86–1.07]) and progression-free survival (HR = 0.98, 95% CI [0.89–1.08]) between NACT and PDS. Subgroup analyses did not demonstrate higher survival for stage IV patients (HR = 0.88, 95% CI [0.71–1.09]) nor for patients with metastatic lesions &gt;5 cm (HR = 0.86, 95% CI [0.69–1.08]) treated with NACT, albeit with some uncertainty due to imprecision. Similarly, no survival benefit was observed in the subgroup of patients with metastatic lesions &gt;10 cm (HR = 0.94, 95% CI [0.78–1.12]). NACT was associated with significantly higher rates of complete cytoreduction (RR = 2.34, 95% CI [1.48–3.71]). Severe peri-operative adverse events were less frequent in the NACT arm (RR = 0.34, 95% CI [0.16–0.72].Conclusion: Patients with stage III and IV epithelial ovarian cancer undergoing NACT or PDS have similar overall survival. NACT is likely associated with higher rates of complete cytoreduction and lower risk of severe adverse events and peri-operative death.
المحاضر المجاني حقوقه و التزاماته
Authors: عبد القادر بان صلاح , نوري امير عماد 
Published: September 2022

من الواجبات التي تقع على عاتق الدولة هو تنظيم حياة الافراد ومن كافة النواحي ، ومن ضمن الفئات التي على الدولة ان تقوم بتنظيم حياتهم هم فئة الخريجين الجدد الذين يبحثون عن عمل ، ونتيجة للظروف التي تواكب بلدنا العزيز من تدهور بالحياة الاقتصادية ومن ارتفاع البطالة ومن عدم قدرة الدولة على تعيين الخريجين ككل من ناحية ومن النقص الحاصل الذي ظهر في الكوادر التدريسية في المدارس وخاصة تلك التي تقع في المناطق النائية من المحافظات ، حيث اظهرت الدراسات بوجود نقص كبير في الكوادر التدريسية مما دفع الدولة الى ابتكار فئة جديدة هم فئة المحاضرين المجانيين ، وهم اشخاص يتعهدون بان يلقوا محاضرات بالمجان في المدارس العراقية شريطة ان يكون له الافضلية عند فتح تعيينات جديدة ، هذه الحالة بالرغم من مساعدتها على اكمال النصاب التدريسي ومساعدتها على سد النقص الحاصل في المدارس الا ان لهذا النظام سلبيات كثيرة ومشاكل جمة ظهرت وقد تظهر بالمستقبل ، منها وضع هؤلاء القانوني وما هي حقوقهم والتزاماتهم وهذا ما حاولنا معالجته من خلال بحثنا هذا .
أثر جائحة كورونا على المستهلك المصرفي في عقد القرض التجاري
Authors: عبد اندلس حامد 
Published: September 2022

أثرت جائحة كورونا على جميع مجالات الحياة ,إذ يواجه العالم تحدي في الوقت الراهن نتيجة جائحة كورونا وما رافقه من اضطرابات اقتصادية , لذلك سعت العديد من الدول لمعالجة الاثار الاقتصادية لجائحة كورونا باللجوء للاقتراض داخليا أو خارجيا لتغطية احتياجاتها .
وتكمن إشكالية البحث في تأثر نشاطات المصارف خلال فترة الازمات المفاجئة, ويصبو البحث إلى حل الاشكاليات المتعلقة بعقد القرض التجاري في ظل الازمات وإيجاد طرق لحماية المستهلك المصرفي كعميل للمصارف لاسيما إذا كان من ذوي الجدارة الائتمانية ,وأن المبادرات التي اتبعتها الكثير من البلدان تدعو لتخفيف الضرر الواقع على العملاء من المؤسسات والأفراد كالأعباء الاقتصادية من خلال تأجيل الأقساط وجميع الاستحقاقات الائتمانية للمصارف في ظل الأزمة ، وعدم فرض غرامات إضافية على التأخير في التسديد لمواجهة هذا الظرف الاستثنائي وفق أجراءات محددة وسليمة وغيرها من الاجراءات, إذ ينبغي على المصارف تحقيق الموازنة بين منح القرض وحجم المخاطر التي قد تتعرض له المصارف.
UPAYA MENINGKATKAN MOTORIK HALUS MELALUI KIRIGAMI UNTUK ANAK USIA DINI 5-6 TAHUN DI TK IQRO ISLAMIC PRESCHOOL BEKASI
Authors: Trilaelasari Ela 
Published: September 2022

Abstrak
Penelitian ini bertujuan untuk mengetahui peningkatan keterampilan motorik halus siswa dengan menggunakan kirigami pada anak usia dini 5-6 tahun pada TK Iqro Islamic Preschool Bekasi.
Penelitian ini merupakan penelitian Tindakan kelas (PTK) kolaboratif yang di laksanakan dalam dua siklus. Subyek penelitian ini adalah anak-anak usia 5-6 tahun. Teknik pengumpulan data menggunakan lembar observasi. Analisis data yang di gunakan adalah deskriptif kualitatif. Peningkatan motorik halus dikatakan berhasil jika persentase keterampilan motorik halus anak mencapai > 65 %.
Berdasarkan analisis persentase hasil penelitian ini adalah hasil observasi pratindakan keterampilan motorik halus siswa adalah sebesar 43,79 %. Setelah diadakan tindakan pada siklus I diperoleh peningkatan persentase sebesar 68,4%. Setelah dilakukan Tindakan pada siklus II diperoleh peningkatan rata-rata keterampilan halus siswa menjadi 73,9%. Dengan demikian hasil analisis menyatakan bahwa dengan kirigami dapat meningkatkan keterampilan motorik halus anak usia dini.

Kata kunci: meningkatkan motorik halus, kirigami, anak usia dini
Reaction of the Soviet Leadership to Rudolf Hess's Flight to England (May–June 1941)
Authors: Невежин В.А. 
Published: September 2022

В статье подводятся итоги трех публикаций автора о восприятии в мае–июне 1941 г. высшим советским руководством сведений о полете в Англию и пребывании там Р. Гесса, заместителя А. Гитлера по руководству Национал-социалистической партией. Автор ввел в оборот ранее не известные источники, которые позволили уточнить некоторые ее аспекты. По мнению автора статьи, в ряде исследований приводятся не подтвержденные источниками версии о реакции высшего партийно-государственного руководства СССР (прежде всего, И.В. Сталина и В.М. Молотова) на это событие. Проведенный тщательный анализ тех пометок, которые оставили Сталин и Молотов в тексте информационного письма советского посла В.Г. Деканозова о «случае с Гессом» (от 21 мая 1941 г.), позволил сделать следующие выводы. У Сталина и Молотова вызвали интерес предположения о наличии раскола нацистской верхушки, в результате которого Гесс якобы вынужден был покинуть Германию. В Кремле приняли к сведению тезис о готовности германской стороны к заключению мирного соглашения с Германией и нежелании англичан вступать в мирные переговоры с ней. На основании документов, присланных В.Г. Деканозовым, а также послом в Лондоне И.М. Майским, И.В. Сталин и В.М. Молотов, несомненно, осознали, что в Германии наблюдается процесс усиления антисоветской пропаганды, в частности, путем издания враждебных СССР печатных изданий.
This paper summarizes the results of three other studies by the same author, all of which focused on how the Soviet leadership perceived the flight of Rudolf Hess, Deputy Führer to Adolf Hitler, to Great Britain in May and June of 1941. The author presents previously unknown primary sources, which helped bring to light certain aspects of the issue. The author believes that a number of studies offer unverified versions of how the USSR leadership (primarily, Joseph Stalin and Vyacheslav Molotov) reacted to this event. Meticulous analysis of the notes left by Stalin and Molotov throughout the briefing letter by the Soviet ambassador Vladimir Dekanozov regarding the «Case of Hess» (May 21, 1941) has led to the following conclusions: Stalin and Molotov entertained the idea that the Nazi leadership was divided and that Hess was allegedly forced to leave Germany as a result. The Kremlin took note of the German side's readiness to sign a peace agreement and the unwillingness of the British side to enter into peace negotiations with Germany. Having read the documents sent by Vladimir Dekanozov and the Ambassador in London, Ivan Maisky, Stalin and Molotov certainly realized that the anti-Soviet propaganda was increasing in Germany, notably through the release of publications that painted the Soviet Union in a negative light.
ANALISIS PERBANDINGAN KINERJA PNS DAN THL PADA DINAS PENDIDIKAN KABUPATEN MINAHASA DI MASA PANDEMI COVID-19
Authors: Gerung Chessy Jenifer , Dotulong Lucky O. H. , Raintung Michael Ch 
Published: September 2022

Kinerja yang baik merupakan suatu langkah untuk menuju tercapainya suatu tujuan organisasi atau instansi, oleh karena itu, kinerja juga merupakan sarana penentua dalam mencapai tujuan organisasi atau instansi sehinggap perlu diupayakan untuk meningkatkan kinerja pegawai. Tujuan penelitian ini adalah untuk mengetahui ada atau tidaknya perbedaan kinerja Kinerja PNS dan THL Pada Dinas Pendidikan Kabupanten Minahasa. Populasi dalam penelitian ini adalah PNS dan THL pada Dinas Pendidikan Kabupaten Minahasa, yang berjumlah 26 orang, yaitu PNS 13 orang dan THL 13 orang. Jenis Penelitian ini menggunakan penelitian komparatif yang bertujuan untuk melihat perbedaan dari variabel yang akan diuji dengan menggunakan analisis uji beda (Independent Sample t-Test). Hasil penellitian menunjukkan bahwa tidak terdapat perbedaan kinerja PNS dan THLpada Dinas Pendidikan Kabupaten Minahasa. Kata Kunci: kinerja pegawai, PNS, THL
ANTESEDEN NIAT BELI DI STARBUCKS COFFE KAWASAN MEGAMAS MANADO DALAM KONTEKS PANDEMIC COVID-19
Authors: Aseng Jehuda , Massie James D.D. , Kawet Raymond Ch 
Published: September 2022

Isu lingkungan menjadi masalah baru di era pemasaran, Enviromentaln Responsibilty merupakan persepsi konsumen tentang pengelolaan ramah lingkungan khusunnya terhadap suatu bisnis. Di saat kondisi pandemic covid-19 yang terjadi saat ini pola konsumsi individu khususnya terhadap makanan maupun minuman berubah, sehingga menjadi faktor keamanan pangan seperti kebersihan, kesehatan, dan karantina merupakan hal yang penting dalam penentuan pengambilan keputusan dibidang layanan makanan dan minuman, karena penyakit covid-19 menyebabkan konsekuensi yang tidak diinginkan. Salah satu perusahaan yang menerapkan konsep green maketing adalah perusahaan Starbucks. Starbucks selalu membawa sesuatu yang menarik pelanggan mulai dari pengembangan produksi adanya tumbler hingga penjualan melalui strategi yang tepat. Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh antara variabel green marketing mix, enviromental responsibility, quarantine, hygiene, dan healthiness terhadap purchase intention. Metode yang digunakan dalam penelitian ini adalah regresi linear berganda. Sampel yang digunakan adalah 61 sampel yang pernah melakukan pembilian di Starbucks Coffe Kawasan Megamas Manado. Hasil dari penelitian ini Green marketing mix tidak berpengaruh signifikan terhadap purchase intention. Envromental Rensponsibility tidak berpengaruh signifikan tehadap purcahse intention. Quarantine berpengaruh signifikan terhadap purchase intention. Hygine berpengaruh signifikan terhadap purchase intention. Helathiness berpengaruh signifikan terhadap purchase intention. Kesimpulan penelitian ini adalah Quarantine, Hygine, Healhiness memiliki pengaruh positif dan signifikan terhadap Purcahse intention Konsumen pada Starbucks Coffe kawasan Megamas Manado.Kata Kunci: green marketing mix, enviromental responsibility, quarantine, hygiene, dan healthiness terhadap purchase intention