bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of gut microbiome-targeted therapies in nonalcoholic fatty liver disease: a systematic review and network meta-analysis
Authors: Song Yijia , Liu Sutong , Zhang Lihui , Zhao Wenxia , Qin Yuanmei , Liu Minghao 
Published: January 2025

BackgroundThe incidence of NAFLD is increasing. Preclinical evidences indicate that modulation of the gut microbiome could be a promising target in nonalcoholic fatty liver disease.MethodA systematic review and network meta-analysis was conducted to compare the effect of probiotics, synbiotics, prebiotics, fecal microbiota transplant, and antibiotics on the liver-enzyme, metabolic effects and liver-specific in patients with NAFLD. The randomized controlled trails (RCTs), limited to English language were searched from database such as Pubmed, Embase, Web of science and Cochrane Library from inception to November 2024. Review Manager 5.3 was used to to draw a Cochrane bias risk. Inconsistency test and publication-bias were assessed by Stata 14.0. Random effect model was used to assemble direct and indirect evidences. The effects of the intervention were presented as mean differences with 95% confidence interval.ResultsA total of 1921 patients from 37 RCTs were eventually included in our study. 23 RCTs evaluated probiotics, 10 RCTs evaluated synbiotics, 4 RCTs evaluated prebiotics, 3 RCTs evaluated FMT and one RCT evaluated antibiotics. Probiotics and synbiotics were associated with a significantly reduction in alanine aminotransferase [ALT, (MD: −5.09; 95%CI: −9.79, −0.39), (MD: −7.38, 95CI%: −11.94, −2.82)] and liver stiffness measurement by elastograph [LSM, (MD: −0.37;95%CI: −0.49, −0.25), (MD: −1.00;95%CI: −1.59, −0.41)]. In addition to, synbiotics was superior to probiotics in reducing LSM. Synbiotics was associated with a significant reduction of Controlled Attenuation Parameter [CAP, (MD: −39.34; 95%CI: −74.73, −3.95)]. Both probiotics and synbiotics were associated with a significant reduction of aspartate transaminase [AST, (MD: −7.81; 95%CI: −15.49, −0.12), (MD: −13.32; 95%CI: −23, −3.64)]. Probiotics and Allogenic FMT was associated with a significant reduction of Homeostatic Model Assessment for Insulin Resistance [HOMA-IR, (MD: −0.7, 95%CI: −1.26, −0.15), (MD: −1.8, 95%CI: −3.53, − 0.07)]. Probiotics was associated with a significant reduction of body mass index [BMI, MD: −1.84, 95%CI: −3.35, −0.33].ConclusionThe supplement of synbiotics and probiotics maybe a promising way to improve liver-enzyme, LSM, and steatosis in patients with NAFLD. More randomized controlled trials are needed to determine the efficacy of FMT and antibiotics on NAFLD. And the incidence of adverse events of MTTs should be further explored.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, CRD42023450093.
Online grocery purchasing in Mississippi: associations with broadband, rurality, and household characteristics
Authors: Davis Will , Jones Jordan W. , Canales Elizabeth , Kim Ayoung , Buys David R. 
Published: January 2025

IntroductionThis study investigates the sociodemographic, economic, and area characteristics associated with Online Grocery Purchasing (OGP) use among adult residents of Mississippi. Understanding these factors is important in a largely rural and low-income state to address barriers and enhance accessibility.MethodsData were collected from a 2022 online pilot survey (n = 398) and secondary sources. A logistic regression model was used to analyze associations between self-reported OGP use and factors including local broadband quality, sociodemographic and economic characteristics, the local food environment, and participation in government nutrition assistance programs.ResultsThe analysis revealed that higher education and income levels are positively associated with the likelihood of OGP use. Conversely, age and rural residence emerged as potential barriers. Although broadband disparities are widespread across Mississippi, self-reported home internet type and local internet speeds showed inconsistent associations with OGP participation across analyses.DiscussionThe findings underscore the nuanced interplay of accessibility and individual-level contexts in shaping OGP behavior. This study highlights the importance of addressing both structural and individual-level barriers to improve access to online grocery services in rural and low-income areas.
Inflammation mediates the association between muscle mass and accelerated phenotypic aging: results from the NHANES 2011–2018
Authors: Bao Shifu , Jimu Weibu , Mu Nai , Yan Fang , Xing Shuxing , Li Tao , Zhou Zheng 
Published: January 2025

BackgroundMuscle mass plays a pivotal role in health maintenance, yet its connection to biological aging remains underexplored. This study investigates the association between appendicular skeletal muscle mass index (ASMI) and phenotypic age(PhenoAge), while examining the mediating role of systemic inflammation.MethodsThe analysis included 7,440 participants from the NHANES 2011–2018. Phenotypic Age Acceleration (PhenoAgeAccel) was calculated as the residuals from regressing PhenoAge on chronological age. Multivariable linear regression analyses were performed to assess the association between ASMI and PhenoAgeAccel. Mediation analysis was conducted to quantify the extent to which systemic inflammation contributes to this association.ResultsOur analysis revealed that higher ASMI is linked to slower biological aging, as evidenced by lower PhenoAgeAccel (β = −0.48, 95% CI: −0.66 to −0.29, p = 0.0001). Systemic inflammation partially mediated this effect, with a mediation proportion of 35.1%. The association varied notably across demographic and health-related subgroups, being particularly significant in females, individuals with obesity, and those with lower physical activity.ConclusionThese findings highlight the critical importance of muscle mass in slowing biological aging, with systemic inflammation emerging as a key biological mediator. The public health implications are substantial, suggesting that targeted interventions—such as resistance training, anti-inflammatory diets, and personalized medical approaches—could play a pivotal role in decelerating biological aging and improving long-term health outcomes.
Dietary practice and associated factors among lactating mothers in Dangila District in the Awi Zone Amhara region Ethiopia, 2022: a cross-sectional study
Authors: Mulatu Sileshi , Mulatu Getasew , Gedif Azeb 
Published: January 2025

IntroductionLactation is the critical time for meeting the nutritional demands of mothers and infants. Mothers from low-income countries, including Ethiopia, are considered nutritionally vulnerable. Good dietary practices for mothers during lactation are therefore important for the good health of their children. The main objective of this study was to assess dietary practice and associated factors of lactating mothers in Dangila Zuria District, Amhara region, Ethiopia, 2022.MethodsA community-based cross-sectional study was conducted among 609 lactating women from March 1st to May 1st 2022. The study participants were selected using a straightforward simple random sampling techniques. Data was collected by using structured questionnaires. The data was entered in Epi-data and exported to SPSS version 23 for analysis. Bi-variable and multi-variable logistic regression analyses were used to see the relevant associations. The variable significantly associated with dietary practice was identified based on a P-value ≤ 0.05.ResultsThis study revealed that only one-third 204 lactating mothers, demonstrated good dietary practices. Notably, several factors were significantly associated with poor dietary practices: mothers with a family size greater than four had 3.01 times higher odds of inadequate dietary habits (AOR = 3.01; 95% CI: 1.56, 9.28), while those with birth intervals of &lt;2 years faced 2.31 times greater odds (AOR = 2.31; 95% CI: 1.49, 3.56). Additionally, daily laborers exhibited a striking 9.35 times higher likelihood of poor dietary practices (AOR = 9.35; 95% CI: 8.02, 19.96), and food-insecure mothers had 4.93 times higher odds of inadequate nutrition (AOR = 4.93; 95% CI: 3.40, 7.16).ConclusionIn conclusion, the dietary practices of lactating mothers were found to be suboptimal, falling below WHO and FAO recommendations. Factors such as family size, birth intervals, maternal occupation (especially daily laborers), and food insecurity were identified as significant contributors. Addressing these issues is crucial. Key stakeholders, including the Ministry of Health (MOH), Regional Health Bureaus (RHB), and health professionals, must work together to alleviate food insecurity, promote optimal family planning, and educate mothers on proper nutrition. Addressing these challenges is essential to achieving global objectives such as reducing malnutrition, improving maternal health, and ensuring healthy child development.
Association between weight-adjusted waist index and Hashimoto’s thyroiditis: insights from NHANES 2007–2012
Authors: Wen Xiaoyong , Mao Yu , Li Zeyu , Chen Guangji , Zhou Shiwei 
Published: January 2025

ObjectiveWhile previous studies have explored the relationship between obesity and levels of thyroid autoantibodies, research using novel indicators such as weight-adjusted waist index (WWI) remains limited. This study aimed to evaluate the potential relationship between WWI and thyroid autoantibody levels, with the objective of improving our understanding of the links between central obesity and Hashimoto’s thyroiditis (HT).MethodsWe conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) cycles from 2007 to 2012. We analyzed the relationship between WWI and levels of thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies (TgAb) through multivariate linear regression and subgroup analyses.ResultsThe study included 7,056 participants with an average age of 49.71 ± 17.66 years, comprising 49.18% females. Mean WWI across the cohort was 11.04 ± 0.84. Analysis revealed a significant positive association between WWI and TPOAb levels (β: 4.78, 95% CI: 1.52, 8.05, p = 0.0041), which remained consistent across all multivariate linear regression models. In contrast, no significant correlation was found between WWI and TgAb levels after adjusting for covariates. Subgroup analysis stratified by gender demonstrated a notable gender-specific effect, where the positive correlation between WWI and TPOAb levels was evident only in females (β: 8.13, 95% CI: 4.14, 12.12, p &lt; 0.0001).ConclusionThis study used WWI as a novel indicator of central obesity and identified a strong association with HT, particularly notable in females. However, further high-quality studies are needed to confirm these findings and explore the underlying biological mechanisms.
Axial length to corneal curvature radius ratio is negatively correlated with choroidal blood flow in myopic children
Authors: Ye Yurong , Hu Zizhong , Su Na , Shen Yeyu , Yuan Songtao 
Published: January 2025

BackgroundThe pathophysiologic mechanisms underlying early-onset myopia remain unclear; in this study, we investigate the pathogenesis by examining the interrelationships between axial length to corneal curvature radius ratio (AL/CR) and choroidal blood flow.MethodsThis cross-sectional study included 202 eyes from myopic children, categorized into 141 eyes with mild myopia, 47 eyes with moderate myopia, and 14 eyes with high myopia. Optical coherence tomography angiography (OCTA) was used to measure choroidal blood flow perfusion within a 6 mm × 6 mm area of the macular region, divided into nine subareas based on ETDRS partitioning: macular fovea, nasal side 1, superior 1, temporal side 1, inferior 1, nasal side 2, superior 2, temporal side 2, and inferior 2. Data on corneal curvature and ocular axial length were collected to calculate the AL/CR, with equivalent spherical lens power, gender, and age gathered for group comparisons, and the correlation between AL/CR and choroidal blood flow perfusion volume was analyzed.ResultsAL/CR was significantly negatively correlated with choroidal blood flow perfusion (P<0.001). Linear regression and mediation analyses indicated that for each unit increase in choroidal blood perfusion volume in nasal region 1, AL/CR decreased by an average of 0.421 units. This relationship is mediated by several factors, with axial length serving as a key mediator.ConclusionAL/CR correlates with choroidal blood flow perfusion, indicating a link between refractive biological parameters and ocular blood circulation. Myopia is an ischemic eye condition that warrants attention to fundus microcirculation changes in myopic children.
Multidrug-resistant ST11-KL64 hypervirulent Klebsiella pneumoniae with multiple bla- genes isolated from children's blood
Authors: Luo Rongmu , Ma Guannan , Yu Qian , Tian Zhengqin , Man Qihang , Shu Xiangrong , Liu Xuetong , Shi Yupeng , Zhang Lei , Wang Jingbo 
Published: January 2025

IntroductionHypervirulent carbapenem-resistant Klebsiella pneumoniae (hv-CRKP) poses an increasing public health risk due to its high treatment difficulty and associated mortality, especially in bone marrow transplant (BMT) patients. The emergence of strains with multiple resistance mechanisms further complicates the management of these infections.MethodsWe isolated and characterized a novel ST11-KL64 hv-CRKP strain from a pediatric bone marrow transplantation patient. Antimicrobial susceptibility testing was performed to determine resistance patterns. Comprehensive genomic analysis was conducted to identify plasmid types, virulence factors, and antimicrobial resistance genes, as well as potential resistance mechanisms associated with mutations and plasmid-mediated variants.ResultsThe isolated hv-CRKP strain exhibited multidrug resistance to carbapenem, tigecycline, and polymyxin. Genomic analysis revealed that the IncHI1B/repB plasmid carried virulence factors (rmpA, ΔrmpA2, iucABCD, iutA), while IncFII/IncR and IncFII plasmids harbored resistance genes [blaCTX-M-65, blaTEM-1B, rmtB, blaSHV-12, blaKPC-2, qnrS1, blaLAP-2, sul2, dfrA14, tet(A), tet(R)]. The coexistence of blaCTX-M-65, blaTEM-1B, blaSHV-12, blaLAP-2,and blaKPC-2 in one hv-CRKP strain is exceptionally rare. Additionally, the Tet(A)-S251A variant in the conjugative plasmid pTET-4 may confer tigecycline resistance. Mutations in MgrB, PhoPQ, and PmrABCDK were identified as potential contributors to increased polymyxin resistance. Interestingly, plasmid-encoded restriction-modification systems and Retron regions were identified, which could potentially confer phage resistance.DiscussionThe combination of virulence and antimicrobial resistance factors in the ST11-KL64 hv-CRKP strain represents a significant challenge for treating immunocompromised pediatric patients. Particularly concerning is the resistance to polymyxin and tigecycline, which are often last-resort treatments for multidrug-resistant infections. The findings highlight the urgent need for effective surveillance, infection control measures, and novel therapeutic strategies to manage such hypervirulent and multidrug-resistant pathogens.
A bibliometric analysis of 30 years of research on transarterial radioembolization (TARE) for hepatocellular carcinoma
Authors: Hu Tongyao , Xu Qifan , Jia Guorong , Wang Tao , Zuo Changjing 
Published: January 2025

IntroductionPatients with advanced hepatocellular carcinoma (HCC) have very limited treatment options, among which transarterial radioembolization (TARE) receives increasing attention, relying on its promising efficacy and fewer side effect. However, a bibliometric analysis of TARE for HCC is still lacking. This study employed bibliometric methods to analyze the related articles over the past three decades, and aimed to identify trends in clinical research comparing TARE to other treatments.MethodsArticles related with TARE for HCC were obtained from the Web of Science (WoS). After screening, the R package Bibliometrix was employed to explore the primary bibliometric characteristics. The number of publications was analyzed and mathematically fitted to a curve using Microsoft Excel 2021 and SPSS 25, and then was plotted in the graph using GraphPad Prism 8.0. VOSviewer, SCImago Graphica, and Pajek were utilized for the analysis of researchers’ co-authorship, co-occurrence, and visualization. Keywords citation burst was detected by CiteSpace software.ResultsA total of 1,110 articles from 1993 to 2023 were included in our final analysis, among which the United States not only ranked the first in term of the number of published articles, also was at the forefront in other important indicators, including the total number of article citations and the average citation frequency. Riad Salem from Northwestern University, also being the organization with the greatest number of research papers, was the most active author and has published 96 papers. The keywords were classified into three clusters: 90Y microspheres for TARE, Basic research on TARE, and Clinical trial of TARE for HCC. Furthermore, we identified the most frequently cited keywords with strong citation bursts since 2020 were “multicenter,” “overall survival” and “PET/CT.”ConclusionOur study employed a bibliometric approach to achieve the visualization research on TARE for HCC, and further revealed the trends and frontiers of TARE research, providing valuable information for researchers to identify the critical and persistent challenges and select potential partners in related area. Based on our analysis, future research focus include the clinical comparative studies on the effect of TARE and TACE combined with immunotherapies or targeted therapy, dosimetry, and personalized TARE therapy for HCC.
Phytochemical investigation and assessment of the anti-inflammatory activity of four Heracleum taxa growing in Turkey
Authors: Kurtul Ekin , Küpeli Akkol Esra , Karpuz Ağören Büşra , Yaylacı Büşra , Bahadır Acıkara Özlem , Sobarzo-Sánchez Eduardo 
Published: January 2025

IntroductionHeracleum L. has been known as “hogweed” and used for inflammatory diseases, including fever, enteritis, and bronchitis, for many years worldwide. The Heracleum genus is also prominently recognized for its high content of coumarins, which are considered a significant group of natural compounds known for their noteworthy anti-inflammatory properties.MethodsThe present study evaluated the anti-inflammatory activity of dichloromethane and methanolic extracts from H. paphlagonicum, H. sphondylium subsp. ternatum, H. sphondylium subsp. elegans, and H. sphondylium subsp. cyclocarpum (100 mg/kg), which have not been previously investigated for their anti-inflammatory properties. Inflammation models induced by carrageenan, prostaglandin E2, and serotonin were employed to evaluate anti-inflammatory activity, using indomethacin (10 mg/kg) as the reference standard. Statistical differences between treatment and control groups were evaluated using ANOVA with Student-Newman-Keuls post-hoc tests. Additionally, the coumarin contents of the extracts were quantified as mg/g by high-performance liquid chromatography.Results and discussionH. sphondylium subsp. cyclocarpum roots displayed the highest inhibition for carrageenan, prostaglandin E2, and serotonin-induced hind paw edema, with inhibition ranges of 22.8%–36.9%, 5.4%–35.7%, and 3.9%–17.9%, respectively, while the inhibition ranges for indomethacin were 12.8%–44.3%, 2.7%–41.3%, and 7.1%–30.6%, respectively. The highest bergapten and imperatorin quantities were found in H. sphondylium subsp. cyclocarpum roots (0.49% and 0.14%) and in H. sphondylium subsp. elegans roots, which had the highest xanthotoxin level (0.06%). Angelicin was detected in H. paphlagonicum, H. sphondylium subsp. elegans, and H. sphondylium subsp. cyclocarpum roots at concentrations of 0.04%, 0.04%, and 0.02%, respectively. The correlation between the highest inhibitory activity observed in H. sphondylium subsp. cyclocarpum roots and the elevated levels of coumarins, particularly bergapten and imperatorin, suggests a potential link between coumarin concentration and anti-inflammatory effects. Additionally, our findings support the traditional use of this genus for treating inflammatory disorders. Further investigations are necessary to identify the active compounds and elucidate the mechanisms of action of these plants, potentially leading to the discovery of novel therapeutic options for the treatment of inflammation.
Median effective dose of remimazolam combined with sufentanil for inhibiting laryngeal mask airway insertion responses in children of different ages
Authors: Li Hongyun , Wang Jinxia , Wei Rong , Jiang Yan 
Published: January 2025

IntroductionWe determined the median effective dose and 95% confidence interval (CI) of remimazolam required to inhibit laryngeal mask airway (LMA) insertion reactions combined with sufentanil 0.3 μg/kg in pediatric anesthesia.MethodsChildren scheduled to undergo elective laryngeal mask anesthesia were divided into the preschool (age: 3–6 years) and school-age (6–12 years) groups. The timer was started after intravenous remimazolam was administered; thereafter, 0.3 μg/kg sufentanil was injected intravenously. The laryngeal mask was placed 3 min after remimazolam was finished. If a positive response to LMA insertion, such as movement, swallowing, coughing, hiccups, or other reactions, was observed during the insertion, the dose was increased by 0.03 mg/kg for the next patient; if there was no response, the dose was decreased by 0.03 mg/kg instead. The trial officially commenced after the first LMA was successfully inserted and continued until alternating positive and negative responses formed seven crossover points. Thereafter, probit regression was performed to calculate the median effective dose (ED50) and 95% effective dose (ED95) with the corresponding 95% CIs. The time from remimazolam administration to the disappearance of the eyelash reflex was recorded. Heart rate and mean arterial pressure were recorded before (T1, baseline values) and 3 min after (T2) intravenous remimazolam administration. Adverse reactions were also noted.ResultsOverall, 52 children were included; 25 belonged to the preschool group and 27 to the school-age group. In the preschool group, the ED50 and ED95 for remimazolam and their 95% CIs were 0.476 (0.447–0.517) mg/kg and 0.554 (0.515–0.688) mg/kg, respectively. In the school-age group, the ED50 and ED95 for remimazolam and corresponding 95% CIs were 0.427 (0.399–0.463) mg/kg and 0.504 (0.467–0.635) mg/kg, respectively. The dosage for the preschool group was significantly higher than that for the school-age group (p = 0.003). Conversely, the time from remimazolam administration to the disappearance of the eyelash reflex; LMA insertion success rate; or incidence of coughing, movement, swallowing, and hiccups did not differ significantly between the two groups.ConclusionRemimazolam can be safely used for laryngeal mask anesthesia induction in pediatric patients.Clinical Trial Registrationhttps://www.chictr.org.cn/, identifier ChiCTR2400087333.