bluuebunny/crossref_metadata_2025_split huggingface dataset:
Death and meaning(lessness): re-examining the African view
Authors: Attoe Aribiah David 
Published: August 2022

AbstractIn much of the emerging literature in African philosophy on the question of life's meaning, little, if anything, has been said about the relationship between African conceptions of death and the question of life's meaning. Drawing from clues in the literature on African metaphysics/philosophy of religion, this article will argue that within the context of an African conception of death, life is ultimately meaningless. To do this, I will begin by curating an African conception of death that sees death as primarily the disembodiment of subjective consciousness. Through this disembodiment, the individual can approach death with meaning in life and pivot into meaning after life. However, I will show this view to be mistaken on several grounds – the implausibility of the metaphysics grounding the possibility of disembodiment; and the idea of a second death inherent in the African conception of death. Thus, I will conclude that the finality of death provides good reason to acknowledge that life is ultimately meaningless.
Childlessness and social and emotional loneliness in middle and later life
Authors: Penning Margaret J. , Wu Zheng , Hou Feng 
Published: August 2022

AbstractDespite theoretical accounts asserting the importance of children for the wellbeing of individuals as they age, research evidence suggests that children may be inconsequential when it comes to loneliness. Yet, there is reason to expect some subgroups may be more vulnerable to the impact of childlessness than others and this may also differ depending on the type of loneliness being assessed. This paper addresses the relationship between childlessness and social and emotional loneliness in middle and later life, including differential vulnerability associated with age, gender and marital/partner status. The study drew on data from three waves (2007, 2012 and 2018) of the Canadian General Social Survey for a nationally representative sample of adults aged 45 and older (N = 49,892). In general, childlessness assumed greater importance with regard to social than emotional loneliness. Women reported lower levels of social loneliness in conjunction with childlessness than men. Further, childlessness was associated with higher levels of overall and social loneliness among older than middle-aged adults. Fewer interactions were evident between marital/partner status and childlessness. Among women specifically, those who were co-habiting, separated/divorced or never married reported lower levels of social loneliness than their married counterparts. In contrast, childlessness was linked to greater emotional loneliness only among separated/divorced men and widowed women. Overall, our results suggest that having children available does matter for feelings of loneliness in middle and later life but that the relationship varies and is contingent on the social contexts (age, gender, marital/partner status) and the type of loneliness (social, emotional) involved.
Vote markets, democracy and relational egalitarianism
Authors: Lippert-Rasmussen Kasper 
Published: August 2022

AbstractThis paper expounds and defends a relational egalitarian account of the moral wrongfulness of vote markets according to which such markets are incompatible with our relating to one another as equals qua people with views on what we should collectively decide. Two features of this account are especially interesting. First, it shows why vote markets are objectionable even in cases where standard objections to them, such as the complaint that they result in inequality in opportunity for political influence across rich and poor people, are inapplicable. Second, it specifies the sense in which, politically speaking, we should relate as equals, and in doing provides a richer version of recent relational egalitarian accounts of the ideal of democracy.
Effects of acute aerobic exercise on mnemonic discrimination performance in older adults
Authors: Callow Daniel D. , Pena Gabriel S. , Stark Craig E. L. , Smith J. Carson 
Published: August 2022

AbstractObjectives:Ample evidence suggests exercise is beneficial for hippocampal function. Furthermore, a single session of aerobic exercise provides immediate benefits to mnemonic discrimination performance, a highly hippocampal-specific memory process, in healthy younger adults. However, it is unknown if a single session of aerobic exercise alters mnemonic discrimination in older adults, who generally exhibit greater hippocampal deterioration and deficits in mnemonic discrimination performance.Methods:We conducted a within subject acute exercise study in 30 cognitively healthy and physically active older adults who underwent baseline testing and then completed two experimental visits in which they performed a mnemonic discrimination task before and after either 30 min of cycling exercise or 30 min of seated rest. Linear mixed-effects analyses were conducted in which condition order and age were controlled, time (pre vs. post) and condition (exercise vs. rest) were modeled as fixed effects, and subject as a random effect.Results:No significant time by condition interaction effect was found for object recognition (p = .254, η2=.01), while a significant reduction in interference was found for mnemonic discrimination performance following the exercise condition (p = .012, η2=.07). A post-intervention only analysis indicated that there was no difference between condition for object recognition (p = .186, η2=.06), but that participants had better mnemonic discrimination performance (p < .001, η2=.22) following the exercise.Conclusions:Our results suggest a single session of moderate-intensity aerobic exercise may reduce interference and elicit better mnemonic discrimination performance in healthy older adults, suggesting benefits for hippocampal-specific memory function.
Citation Metrics for Legal Information Retrieval: Scholars and Practitioners Intertwined?
Authors: Wiggers Gineke , Verberne Suzan , Zwenne Gerrit-Jan 
Published: August 2022

AbstractThis paper is written by Gineke Wiggers, Suzan Verberne and Gerrit-Jan Zwenne and examines citations in legal documents in the context of bibliometric-enhanced legal information retrieval. It is suggested that users of legal information retrieval systems wish to see both scholarly and non-scholarly information, and legal information retrieval systems are developed to be used by both scholarly and non-scholarly users. Since the use of citations in building arguments plays an important role in the legal domain, bibliometric information (such as citations) is an instrument to enhance legal information retrieval systems. This paper examines, through literature and data analysis, whether a bibliometric-enhanced ranking for legal information retrieval should consider both scholarly and nonscholarly publications, and whether this ranking could serve both user groups, or whether a distinction needs to be made. Their literature analysis suggests that for legal documents, there is no strict separation between scholarly and non-scholarly documents. There is no clear mark by which the two groups can be separated, and in as far as a distinction can be made, literature shows that both scholars and practitioners (non-scholars) use both types. They perform a data analysis to analyze this finding for legal information retrieval in practice, using citation and usage data from a legal search engine in the Netherlands. They first create a method to classify legal documents as either scholarly or non-scholarly based on criteria found in the literature. We then semi- automatically analyze a set of seed documents and register by what (type of) documents they are cited. This resulted in a set of 52 cited (seed) documents and 3086 citing documents. Based on the affiliation of users of the search engine, we analyzed the relation between user group and document type. The authors’ data analysis confirms the literature analysis and shows much crosscitations between scholarly and non-scholarly documents. In addition, we find that scholarly users often open non-scholarly documents and vice versa. Our results suggest that for use in legal information retrieval systems citations in legal documents measure part of a broad scope of impact, or relevance, on the entire legal field. This means that for bibliometric-enhanced ranking in legal information retrieval, both scholarly and non-scholarly documents should be considered. The disregard by both scholarly and non-scholarly users of the distinction between scholarly and non-scholarly publications also suggests that the affiliation of the user is not likely a suitable factor to differentiate rankings on. The data in combination with literature suggests that a differentiation on user intent might be more suitable.
Arctic Climate Feedbacks in ERA5 Reanalysis: Seasonal and Spatial Variations and the Impact of Sea‐Ice Loss
Authors: Jenkins Matthew T. , Dai Aiguo 
Published: August 2022

AbstractRadiative climate feedbacks in the Arctic have been extensively studied, but their spatial and seasonal variations have not been thoroughly examined. Using ERA5 reanalysis data, we examine seasonal variations in Arctic climate feedbacks and their relationship to sea‐ice loss based on changes from 1950–1979 to 1990–2019. The spring and summer seasons experienced large sea‐ice loss, strong surface albedo feedback, and large oceanic heat uptake. Arctic clouds exerted small net cooling in May‐June‐July but moderate warming during the cold season, especially over areas with large sea‐ice loss where cloud liquid and ice water content increased. Arctic water vapor feedback peaked in summer but was weak and uncorrelated with sea‐ice loss. Arctic positive lapse rate feedback (LRF) was strongest in winter over areas with large sea‐ice loss and weak inversion but uncorrelated with atmospheric stability, suggesting that oceanic heating from sea‐ice loss led to enhanced surface warming and the positive LRF.
ER stress and UPR in Alzheimer’s disease: mechanisms, pathogenesis, treatments
Authors: Ajoolabady Amir , Lindholm Dan , Ren Jun , Pratico Domenico 
Published: August 2022

AbstractAlzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by gradual loss of memory and cognitive function, which constitutes a heavy burden on the healthcare system globally. Current therapeutics to interfere with the underlying disease process in AD is still under development. Although many efforts have centered on the toxic forms of Aβ to effectively tackle AD, considering the unsatisfactory results so far it is vital to examine other targets and therapeutic approaches as well. The endoplasmic reticulum (ER) stress refers to the build-up of unfolded or misfolded proteins within the ER, thus, perturbing the ER and cellular homeostasis. Emerging evidence indicates that ER stress contributes to the onset and development of AD. A thorough elucidation of ER stress machinery in AD pathology may help to open up new therapeutic avenues in the management of this devastating condition to relieve the cognitive dementia symptoms. Herein, we aim at deciphering the unique role of ER stress in AD pathogenesis, reviewing key findings, and existing controversy in an attempt to summarize plausible therapeutic interventions in the management of AD pathophysiology.
Diagnostic accuracy of symptoms for an underlying disease: a simulation study
Authors: Chao Yi-Sheng , Wu Chao-Jung , Lai Yi-Chun , Hsu Hui-Ting , Cheng Yen-Po , Wu Hsing-Chien , Huang Shih-Yu , Chen Wei-Chih 
Published: August 2022

AbstractSymptoms have been used to diagnose conditions such as frailty and mental illnesses. However, the diagnostic accuracy of the numbers of symptoms has not been well studied. This study aims to use equations and simulations to demonstrate how the factors that determine symptom incidence influence symptoms’ diagnostic accuracy for disease diagnosis. Assuming a disease causing symptoms and correlated with the other disease in 10,000 simulated subjects, 40 symptoms occurred based on 3 epidemiological measures: proportions diseased, baseline symptom incidence (among those not diseased), and risk ratios. Symptoms occurred with similar correlation coefficients. The sensitivities and specificities of single symptoms for disease diagnosis were exhibited as equations using the three epidemiological measures and approximated using linear regression in simulated populations. The areas under curves (AUCs) of the receiver operating characteristic (ROC) curves was the measure to determine the diagnostic accuracy of multiple symptoms, derived by using 2 to 40 symptoms for disease diagnosis. With respect to each AUC, the best set of sensitivity and specificity, whose difference with 1 in the absolute value was maximal, was chosen. The results showed sensitivities and specificities of single symptoms for disease diagnosis were fully explained with the three epidemiological measures in simulated subjects. The AUCs increased or decreased with more symptoms used for disease diagnosis, when the risk ratios were greater or less than 1, respectively. Based on the AUCs, with risk ratios were similar to 1, symptoms did not provide diagnostic values. When risk ratios were greater or less than 1, maximal or minimal AUCs usually could be reached with less than 30 symptoms. The maximal AUCs and their best sets of sensitivities and specificities could be well approximated with the three epidemiological and interaction terms, adjusted R-squared ≥ 0.69. However, the observed overall symptom correlations, overall symptom incidence, and numbers of symptoms explained a small fraction of the AUC variances, adjusted R-squared ≤ 0.03. In conclusion, the sensitivities and specificities of single symptoms for disease diagnosis can be explained fully by the at-risk incidence and the 1 minus baseline incidence, respectively. The epidemiological measures and baseline symptom correlations can explain large fractions of the variances of the maximal AUCs and the best sets of sensitivities and specificities. These findings are important for researchers who want to assess the diagnostic accuracy of composite diagnostic criteria.
MeasureIce: accessible on-the-fly measurement of ice thickness in cryo-electron microscopy
Authors: Brown Hamish G. , Hanssen Eric 
Published: August 2022

AbstractIce thickness is arguably one of the most important factors limiting the resolution of protein structures determined by cryo-electron microscopy (cryo-EM). The amorphous atomic structure of the ice that stabilizes and protects biological samples in cryo-EM grids also imprints some additional noise in cryo-EM images. Ice that is too thick jeopardizes the success of particle picking and reconstruction of the biomolecule in the worst case and, at best, deteriorates eventual map resolution. Minimizing the thickness of the ice layer and thus the magnitude of its noise contribution is thus imperative in cryo-EM grid preparation. In this paper we introduce MeasureIce, a simple, easy to use ice thickness measurement tool for screening and selecting acquisition areas of cryo-EM grids. We show that it is possible to simulate thickness-image intensity look-up tables, also usable in SerialEM and Leginon, using elementary scattering physics and thereby adapt the tool to any microscope without time consuming experimental calibration. We benchmark our approach using two alternative techniques: the “ice channel” technique and tilt-series tomography. We also demonstrate the utility of ice thickness measurement for selecting holes in gold grids containing an Equine apoferritin sample, achieving a 1.88 Ångstrom resolution in subsequent refinement of the atomic map.
Bioengineered textiles with peptide binders that capture SARS-CoV-2 viral particles
Authors: Navone Laura , Moffitt Kaylee , Johnston Wayne A. , Mercer Tim , Cooper Crystal , Spann Kirsten , Speight Robert E. 
Published: August 2022

AbstractThe use of personal protective equipment (PPE), face masks and ventilation are key strategies to control the transmission of respiratory viruses. However, most PPE provides physical protection that only partially prevents the transmission of viral particles. Here, we develop textiles with integrated peptide binders that capture viral particles. We fuse peptides capable of binding the receptor domain of the spike protein on the SARS-CoV-2 capsid to the cellulose-binding domain from the Trichoderma reesei cellobiohydrolase II protein. The hybrid peptides can be attached to the cellulose fibres in cotton and capture SARS-CoV-2 viral particles with high affinity. The resulting bioengineered cotton captures 114,000 infective virus particles per cm2 and reduces onwards SARS-CoV-2 infection of cells by 500-fold. The hybrid peptides could be easily modified to capture and control the spread of other infectious pathogens or for attachment to different materials. We anticipate the use of bioengineered protective textiles in PPE, facemasks, ventilation, and furnishings will provide additional protection to the airborne or fomite transmission of viruses.
Keep the Ball Rolling: Sustained Multiturn Conversational Episodes Are Associated With Child Language Ability
Authors: Beiting Molly , Alper Rebecca M. , Luo Rufan , Hirsh-Pasek Kathy 
Published: August 2022

Purpose:
The purpose of this study was to examine the relationship between interaction quality and child language ability. We focused on one promising interaction quality indicator—the rate of multiturn conversational episodes. We also explored whether the relationship between rate of single conversational turns and language ability changed when the child's nonverbal behaviors were considered in addition to verbal conversational turns. To limit the potential of socioeconomic status as a confounder, participants included only families living in underresourced households.

Method:

Secondary analyses were conducted using baseline data (
N
= 41 dyads enrolled,
N
= 27 analyzed) from a longitudinal study. All families were living in low-income households (i.e., below 200% of the Federal Poverty Level) and 12 were English–Spanish bilingual (15 English-only). Mothers and their children (13 to 27 months) participated in video-recorded play and reading interactions at home. Trained observers transcribed and coded the child's and caregiver's verbal and nonverbal behaviors. Linear regression models examined the relationship between the number of conversational turns and child language ability.

Results:
Child language ability was significantly and positively associated with the number of verbal–nonverbal single turns and multiturn conversational episodes, but not single verbal-only turns.

Conclusions:
For children still acquiring language, it is important to account for nonverbal contributions to conversation. Child language ability was significantly and positively associated only with the conversational turn variables that included the child's nonverbal behaviors. Further investigation is needed to understand whether number of turns within conversational episodes is a better indicator of interaction quality than sheer number of conversational turns. Implications for caregiver-implemented interventions are discussed.

Supplemental Material:

https://doi.org/10.23641/asha.20452575
Stellar evolution models with overshooting based on 3-equation non-local theories
Authors: Ahlborn F. , Kupka F. , Weiss A. , Flaskamp M. 
Published: August 2022

Context. Convective overshoot mixing is a critical ingredient of stellar structure models but is treated in most cases by ad hoc extensions of the mixing-length theory for convection. Advanced theories that are both more physical and numerically treatable are needed.
Aims. Convective flows in stellar interiors are highly turbulent. This poses a number of numerical challenges for the modelling of convection in stellar interiors. We included an effective turbulence model in a 1D stellar evolution code in order to treat non-local effects within the same theory.
Methods. We used a turbulent convection model that relies on the solution of second order moment equations. We implemented this into a state-of-the-art 1D stellar evolution code. To overcome a deficit in the original form of the model, we took the dissipation due to buoyancy waves in the overshooting zone into account.
Results. We compute stellar models of intermediate mass main-sequence stars of between 1.5 and 8 M⊙. Overshoot mixing from the convective core and modified temperature gradients within and above it emerge naturally as a solution of the turbulent convection model equations.
Conclusions. For a given set of model parameters, the overshooting extent determined from the turbulent convection model is comparable to other overshooting descriptions, the free parameters of which had been adjusted to match observations. The relative size of the mixed cores decreases with decreasing stellar mass without additional adjustments. We find that the dissipation by buoyancy waves constitutes a necessary and relevant extension of the turbulent convection model in use.
Safety of teaching endoscopic ultrasound-guided gastroenterostomy (EUS-GE) can be improved with standardization of the technique
Authors: Park Kenneth H. , Rosas Ulysses S. , Liu Quin Y. , Jamil Laith H. , Gupta Kapil , Gaddam Srinivas , Nissen Nicholas , Thompson Christopher C. , Lo Simon K. 
Published: August 2022

Abstract
Background and study aims Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) is a novel technique developed to manage gastric outlet obstruction (GOO). It involves creating a fistula between the stomach and the proximal small bowel using an electric cautery-enhanced lumen-apposing metal stent (ECE-LAMS) with EUS guidance. We aimed to publish our experience in improving teaching of this technique to practicing endoscopists with a wide range of experience by comparing the outcomes before and after standardization of procedural steps.
Methods All EUS-GEs performed for inoperable GOO at a single institution from 2014 to 2021 were retrospectively analyzed. The technique was taught by one experienced endoscopist with prior expertise. Five advanced endoscopists with prior EUS and ECE-LAMS placement experience participated. The impact of standardization on outcomes (clinical and technical success, length of stay [LOS], procedure time, and adverse events [AEs]) was compared.
Results A total 41 EUS-GEs were performed (5 before and 36 after standardization) by endoscopists with practice experience ranging from 2 to 13 years. The patient population was similar in age and sex. Standardization was associated with significantly higher rates of technical success (100 % vs 60 %, P = 0.01) and lower peri-procedural AEs (2.8 % vs 40 %, P = 0.03). Two AEs in the pre-standardized group were gastric perforation and gastrocolic fistula creation. One AE in the post-standardized group was gastric perforation. Procedure time, clinical success, and LOS showed improvement, although it was not statistically significant.
Conclusions Teaching EUS-GE after standardizing the procedure was associated with a significant increase in technical success and a decrease in AEs irrespective of prior total experiences.
Fallbericht: Von der Nachforderung zur Analgesie zur Polytrauma-Reanimation in der Häuslichkeit
Authors: Scheltz Claudia , Jakob André , Port Anne , Nigbur Stefan 
Published: August 2022

ZusammenfassungDer vorliegende Fallbericht beschreibt, wie eine anfänglich harmlos anmutende Nachforderung zur Analgesie bei Sturz in der Häuslichkeit in einer erfolglosen Polytrauma-Reanimation mit
erweiterten invasiven Maßnahmen mündet. Was hat das Rettungsteam zu beachten? Wurden alle therapeutischen Mittel ausgenutzt? Liegt gegebenenfalls eine unklare/nicht natürliche Todesart vor?
Es erfolgt eine rechtsmedizinische Obduktion zur Klärung der offenen Fragen.