bluuebunny/crossref_metadata_2025_split huggingface dataset:
CNN Technique For Detecting Alzheimer’s Disease by using MRI Images
Authors: Jathinsai Dronavalli , Narisetti Suhas , Pilla Adi Vishnu , P Sasi kumar 
Published: June 2022

Abstract
Alzheimer’s Disease(AD) is very common neurological diseases these days. Alzheimer’s is one such gradual disorder that destroys memory and other significant mental functions that leads to dementia. It is necessary to detect and treat it in the initial stages itself in order to avoid any major disintegration. Using normal medical methods AD is very difficult to detect, So they used various classifications using MRI images to detect. In order to get better result, Image acquisition and pre-processing has been done. Over these years there are several approaches to detect and treat the brain diseases, now as the technology progressing rapidly this project has come up with an idea to integrate deep learning techniques to detect and understand the severity of brain’s condition of patient.
Stochastic Model Predictive Control Strategy with Short-term Forecast Optimal SOC for a Plug-in Hybrid Electric Vehicle
Authors: Lin Xinyou , Chen Xiankang , Xu Xinhao 
Published: June 2022

Abstract
Both the stochastic traffic information and State of Charge (SOC) are great impact on the performance of the plug-in parallel hybrid electric vehicle (PHEV). The application of velocity prediction offers the forthcoming trip information directly to estimate the driving power and arrange the SOC. To address this issue, a Stochastic Model Predictive Control (SMPC) based energy management strategy ( EMS) considering short-term forecast optimal SOC is proposed. Firstly, a multiple linear regression of engine and battery is developed for SMPC oriented application, respectively. Then, the velocity prediction model is developed based Markov Chain and the reference SOC optimized by Dynamic Programming (DP) using the forthcoming information. On this basis, the SMPC based EMS with the short-term optimal SOC is constituted. Finally, the various prediction horizon and driver styles are discussed to validate the proposed strategy. The normal MPC and the DP are used as benchmark strategies for comparison to evaluate the evolution of short-term optimal SOC and performance of SMPC based EMS. The test results indicate that the SMPC with the short-term optimal SOC made it possible to promote the EMS with capable of significantly improving the fuel economy of the plug-in PHEV.
Does new-type urbanization curb haze pollution? A case study from China
Authors: Yang Shuwang , Liu Shanshan , Wu Ting , Zhai Ziyu 
Published: June 2022

Abstract
The rapid urbanization process has led to a high concentration of population and economic activities in urban space, thus leading to severe environmental pollution. The concept of new-type urbanization has been proposed in China to combat the pollution associated with urbanization, whereas little literature has focused on correctly identifying the impact and its influencing mechanism of new-type urbanization on haze pollution to improve the quality of urban development. Therefore, this study analyzed the theoretical mechanism of the impact of new-type urbanization on haze pollution, uses Chinese provincial-level panel data from 2007 to 2018, and employed a STIRPAT model with interaction effects for empirical testing. The results found that new-type urbanization significantly reduced haze pollution levels nationwide and in the central and western regions during the study period. In terms of the influencing mechanism, new-type urbanization reduced haze pollution by optimizing the level of intensive urban land use, upgrading the industrial structure and enhancing technological innovation. However, the influencing mechanism was regionally heterogeneous. This research provides a theoretical basis for better implementation of new-type urbanization construction and effective promotion of green and sustainable urban development.
Effects of dry season supplementation of Calliandra calothyrsus leaf-meal mixed with maize-bran on dairy cattle milk productivity in the West Usambara Highlands, Tanzania
Authors: Maleko David Dawson , Msalya George M. , Mtei Kelvin M. 
Published: June 2022

Abstract
The dry seasons decline in milk production due to insufficient feed supply to dairy cattle poses a great challenge to sustainability of smallholder dairy production systems in Tanzania. Locally produced leguminous fodder tree leaf meals combined with maize bran provide a great potential for overcoming the dry season protein-energy deficit in the basal roughage feeds. This study evaluated the effects of dry season Calliandra calothyrsus (Calliandra) leaf-meal: maize-bran based protein-energy homemade supplementary ration (HSR) on milk production of lactating cross-bred dairy cows in the Western Usambara Highlands (WUHs), Tanzania. Complete randomized design was employed whereby four groups of 4 lactating dairy cows were subjected to four levels of HSR rationed at 0, 2, 4 and 6 kg/cow/day. The lactating cows which were not subjected to HSR supplementation (0 kg/cow/day) were left under farmers’ feeding practices as a control. HSR had significant effect on dry season milk yields (P < 0.001) whereby milk yields were 2.7, 4.5, 5.6 and 6.1 litres/cow/day for 0, 2, 4 and 6 kg HSR/cow/day, respectively. In addition, simulated year-round daily milk yields indicated that 4 and 6 kg HSR/cow/day would double the milk yields. Nevertheless, there was overall significant difference in the income to cost ratios (P = 0.02) whereby it was 0.50, 0.79, 1.06 and 1.09 for 0, 2, 4 and 6 kg HSR/cow/day, respectively. However, the income to cost ratios for 4 and 6 kg HSR/cow/day did not differ significantly (P < 0.05). In conclusion, if the dairy farmers in WUHs are to produce profitable milk amounts during the dry seasons the supplementation level of 4 kg HSR/cow/day to the basal diets is recommended.
Upper gastrointestinal bleeding related to an eroded gastrosplenic collateral lately after splenic artery embolization: a case report and review of the literature
Authors: Thillo Anna Van , Buyck Pieter-Jan , Gool Stijn Van , Croonen Cleo , Maleux Geert 
Published: June 2022

Abstract
Background
Upper gastrointestinal, non-variceal haemorrhage can be related to various etiologies, including peptic ulcer, neoplasm, gastritis, Dieulafoy lesions and other, rare underlying diseases. In this report, we present another, very rare etiology of arterial, gastric bleeding.
Case presentation
: A 49-year-old man presented with melena; gastroscopy revealed blood in the stomach without active bleeding source. Computed tomography angiography demonstrated a cluster of enlarged gastrosplenic arterial collaterals in the gastric wall and coils in the splenic artery, related to an embolization procedure 30-years ago for splenic trauma. Definitive treatment included catheter-directed glue embolization of the left gastric artery and the enlarged gastrosplenic collaterals. The postinterventional course was uneventful and no recurrence of upper gastrointestinal bleeding was noted after 6 months of follow-up.
Conclusions
Upper gastrointestinal bleeding associated with eroded gastrosplenic collaterals can be successfully treated with glue-embolization.
The abnormal expression of circ-ARAP2 promotes ESCC progression through regulating miR-761/FOXM1 axis-mediated stemness and the endothelial-mesenchymal transition
Authors: Xu Pei , Wang Lei , Liu Qingtao , Gao Pengkai , Hu Fengqing , Xie Xiao , Jiang Lianyong , Bi Rui , Ding Fangbao , Yang Qi , Xiao Haibo 
Published: June 2022

Abstract
Circular RNAs (circRNAs) belong to a novel class of noncoding RNA that gained more attention in human cancer pathogenesis. The role of circRNA in esophageal squamous cell carcinoma (ESCC) is largely unclear. Present investigation was to characterize new circRNAs regulating ESCC progression and explore the regulatory mechanisms in ESCC. In this study, circRNAs differentially expressed in ESCC and adjacent normal tissues were characterized via high-throughput sequencing. Then the differentially expressed circRNA between ESCC and adjacent normal tissues were investigated using Rt-qPCR. The role of circ-ARAP2 expression on tumor progression were detected in both in vivo and in vitro. Luciferase reporter assays were used to identify the relationships among circ-ARAP2, microRNA (miR)-761 and the cell cycle regulator Forkhead Box M1 (FOXM1). The result of the expression profile analyses regarding human circRNAs in ESCC demonstrated that circ-ARAP2 was up-regulated significantly in both ESCC tissues and cell lines. Downregulation circ-ARAP2 suppressed ESCC proliferation, tumor growth and metastasis inboth in vivo and in vitro. The data also suggested that miR-761 and FOXM1 were circ-ARAP2 downstream targets which were confirmed through luciferase reporter analysis. Overexpression of FOXM1 or inhibiting miR-761 restored ESCC cell proliferation and invasion ability after silencing circ-ARAP2. The study also found that circ-ARAP2 influenced the endothelial-mesenchymal transition (EMT) and cancer stem cells differently by regulating miR-761/FOXM1. In one word, the results demonstrated that abnormal circ-ARAP2 expression promoted ESCC progression by regulating miR-761/FOXM1 axis-mediated stemness and EMT.
Prevention of penehyclidine on postoperative nausea and vomiting in patients with thyroid surgery: a prospective, randomized, double-blinded comparison
Authors: Lu Ting , Li Rongrong , Sun Jiacheng , Chen Jing 
Published: June 2022

Abstract
Backgroud: Postoperative nausea and vomiting (PONV) is one of the most common complication after thyroid surgery under general anesthesia. Propofol-based total intravenous anesthesia (TIVA) has been documented to prevent PONV in patients undergoing thyroid surgery. Penehyclidine, an anticholinergic agent with an elimination half-life over 10 hours, is widely used as premedication to reduce glandular secretion. This study was to explore the preventative effects of penehyclidine with propofol based TIVA to single-TIVA on PONV in patients undergoing thyroid surgery.Methods: A total of 100 patients scheduled for thyroid surgery were randomly assigned into penehyclidine group or TIVA group. Propofol was used for TIVA in all patients. There were no patients who received premedication. Patients were administrated with 5ml of normal saline or 0.5mg of penehyclidin soon after anesthesia induction. The incidence of nausea and vomiting, severity of nausea, the requirement of rescue antiemetics, and adverse effects were investigated during the first 24 hours in 2 time periods (0-2 h and 2-24 h). Results: The overall PONV incidence during the 24 h after surgery was significantly lower in the penehyclidine group compared with the TIVA group (12% vs 36%, P < 0.005). Besides, the incidence of nausea and vomiting were significantly lower in the penehyclidine group compared with the TIVA group at 2-24 h after surgery. However, there was no significant difference between the two groups at 0-2 h after surgery.Conclusions: Penehyclidine with propofol based TIVA was more effective in PONV than TIVA, especially 2-24 h after thyroid surgery. Trial registration: https://www.chictr.org.cn/edit.aspx?pid=132463&htm=4 (Ref: ChiCTR2100050278, the full date of first registration: 25/08/2021).
MicroRNA-34a-5p promotes the progression of osteoarthritis secondary to developmental dysplasia of the hip by restraining SESN2-induced autophagy
Authors: Wang Jun , Sun Yanshan , Xu Meng , Wang Congcong , Liu Xiaoguang , Li Xiaopeng , Zhang Yimin 
Published: June 2022

Abstract
Osteoarthritis (OA), a late-stage complication of developmental dysplasia of the hip (DDH), is a key factor leading to further degeneration of joint function. Studies have shown that Sestrin2 (SESN2) is a positive regulator in protecting articular cartilage from degradation. However, the regulatory effects of SESN2 on DDH-OA and its upstream regulators still remain obscure. Here, we first identified that the expression of SESN2 significantly decreased in the cartilage of DDH-OA samples, with an expression trend negatively correlated with OA severity. Using RNA sequencing, we identified that the upregulation of miR-34a-5p may be an important factor for the decrease in SESN2 expression. Mechanistically, we showed that miR-34a-5p could significantly inhibit the expression of SESN2, thereby promoting the activity of the mTOR signaling pathway. We also found that miR-34a-5p significantly inhibited SESN2-induced autophagy. We further validated that knocking down miR-34a-5p in vivo resulted in significant increase of SESN2 expression and autophagy activity in DDH-OA cartilage. Our study suggests that miR-34a-5p is a negative regulator of DDH-OA, and may provide a new target for the prevention of DDH-OA.
Correlation between serum total bilirubin and survival in advanced cancer with obstructive jaundice after percutaneous biliary drainage
Authors: Zhang Fujun , Zhu Wenliang , Guo Huanqing , Hu Pan , He Xu 
Published: June 2022

Abstract
Purpose
The main purpose of our study was to evaluate the impact of a decreased proportion of total serum bilirubin after percutaneous transhepatic biliary drainage (PTBD) on survival and to identify prognostic factors associated with survival in patients with malignant obstruction jaundice (MOJ).
Methods
From July 2010 to February 2021, 269 patients with MOJ were included. Survival time and prognostic factors were analyzed by Kaplan–Meier curves and the Cox model. The cut-off value of a decrease in the proportion of total serum bilirubin level that predicted patient mortality was determined by receiver operating characteristic (ROC) curves.
Results
The overall median survival time after PTBD was 135 days (min13-max1276 days-95% IC:117–153). The overall survival (OS) improved from 95 days to 243 days when the procedure achieved functional success. Multivariate analysis demonstrated that functionally successful drainage and post-drainage treatment were independent positive prognostic factors, but the total bilirubin after drainage and tumor size were independent negative predictive values. The cut-off value of the proportional decrease in the total serum bilirubin level for predicting the clinical prognosis was 0.44.
Conclusions
Palliative care after drainage can prolong patient survival and improve their quality of life. A decreased proportion of total serum bilirubin after PTBD could be used to predict the survival prognosis in patients.
Sub-retinal pigment epithelium tubules in non- neovascular age-related macular degeneration
Authors: Fragiotta Serena , Parravano Mariacristina , Sacconi Riccardo , Costanzo Eliana , Geronimo Daniele , Prascina Francesco , Capuano Vittorio , Souied Eric H , Han Ian C. , Mullins Robert , Querques Giuseppe 
Published: June 2022

Abstract
Purpose
To describe a novel optical coherence tomography (OCT) signature resembling sub-retinal pigment epithelium (RPE) tubules (SRT) in non-neovascular age-related macular degeneration (AMD).
Methods
Patients suffering from non-neovascular AMD with complete medical records and multimodal imaging were retrospectively revised in three different tertiary care centers. Multimodal imaging included color fundus photograph, spectral-domain OCT (Spectralis, Heidelberg Engineering, Germany), fundus autofluorescence, OCT angiography (RTVue XR Avanti, Optovue, Inc., Fremont, CA).
Results
A total of 7 eyes of 7 patients with drusenoid pigment epithelium detachment (PED) were consecutively analyzed. The sub-RPE tubules appeared as ovoidal structures with a hyperreflective contour and hyporeflective interior appreciable in the sub-RPE-basal lamina (BL) space on OCT B-scan. The anatomical location of the sub-RPE formations was lying above the Bruch’s membrane in 5/7 cases (71.4%) or floating in the sub-RPE-BL space in 2/7 cases (28.6%). En-face OCTA revealed a curvilinear tubulation-like structure corresponding to SRT without flow signal.
Conclusions
Sub-RPE tubules represent a newly identified OCT signature observed in eyes with drusenoid PED. The presumed origin may include a variant of calcified structure or alternatively activated RPE cells with some residual BL or basal laminar deposits attracted to BrM for craving oxygen.
Prognostic Impact of Conversion Hepatectomy for Initially Unresectable Colorectal Liver Metastasis
Authors: Takamizawa Yasuyuki , Inoue Manabu , Moritani Konosuke , Tsukamoto Shunsuke , Esaki Minoru , Shimada Kazuaki , Kanemitsu Yukihide 
Published: June 2022

Abstract
Purpose: This study evaluated the prognostic impact of conversion hepatectomy in patients with initially unresectable colorectal liver metastasis (CRLM) and to identify prognostic factors after conversion hepatectomy.Methods: Correlations of conversion hepatectomy with relapse-free survival (RFS) and overall survival (OS) were retrospectively investigated in 554 consecutive patients who underwent hepatectomy for CRLM in 2000–2017. Prognostic factors after conversion hepatectomy were examined in multivariable analysis.Results: Five hundred and nine patients (92%) had initially resectable CRLM at the time of diagnosis and underwent hepatectomy (primary resection group) and 45 (8%) underwent conversion hepatectomy following chemotherapy (conversion group). The 5-year RFS was 30.0% in the primary resection group and 19.8% in the conversion group (p=0.042); the respective 5-year OS rates were 62.0% and 52.4% (p=0.253). Multivariable analysis did not identify conversion hepatectomy as a significant prognostic factor for RFS (hazard ratio [HR] 0.95, 95% confidence interval [CI] 0.65–1.38, p=0.787) or OS (HR 1.12, 95% CI 0.69–1.83, p=0.643). In the conversion group, multivariable analysis identified timing of liver metastases (synchronous: HR 3.14, 95% CI 1.20–8.24, p=0.020) and the preoperative CEA level to be independent prognostic factors for RFS (>5 ng/ml: HR 3.10, 95% CI 1.45–6.61, p=0.003) and OS (>5 ng/ml: HR 3.29, 95% CI 1.18–9.17, p=0.023).Conclusions: RFS and OS rates after conversion hepatectomy were not inferior to those after primary resection in patients with CRLM. Patients with a normal CEA level before hepatectomy can be expected to have a good long-term prognosis after conversion hepatectomy.
Heparin-modified acellular dermal matrix/chitosan-doped polydopamine nanoparticles composite sponge scaffold loaded with CGF: promoting full-thickness defect wound healing
Authors: Yang Lei , Chen Lianglong , Huang Chaoyang , Zhong Yu , Chen Yujia , Zhang Huihui , Zheng Zijun , Jiang Ziwei , Wei Xuerong , Peng Yujie , Huang Lei , Niu Libin , Gao Yanbin , Ma Jun 
Published: June 2022

Abstract
Background
Although acellular dermal matrix (ADM) and concentrated growth factor (CGF) are both used in regenerative medicine, CGF has been hampered by problems such as burst release, and ADM is only used as an outer dressing for wound healing. In this study, we aim to prepare composite scaffolds (CADMS-G-2-Hep) with good NIR photothermal response, antibacterial activity, and drug delivery ability by introducing polydopamine nanoparticles (PDA NPS) with excellent NIR photothermal conversion ability into ADM and chitosan (CS) interpenetrating network structure and heparinization modification.
Method
Firstly, a physical-chemical double cross-linked composite network was constructed by using chemical cross-sections and the mutual entanglement of ADM and CS chains under freezing conditions. Secondly, the heparinization modification made the composite scaffold with good biocompatibility and cell/tissue affinity, significantly promoting cell adhesion and proliferation and achieving adequate fixation and slow release of CGF. Finally, PDA-NPS have excellent NIR photothermal conversion ability and can significantly promote the survival of autologous skin grafts in rats. One-way ANOVA with Bonferroni posthoc analysis was used to determine whether a statistically, significant difference exists between groups.
Result
In vivo experiments, this composite biomaterial promoted angiogenesis, cell proliferation, and adhesion, improved skin survival of full-thickness skin defect wounds, reduced graft shrinkage and scar formation and promoted wound healing and tissue remodeling.
Conclusion
CADMS-G-2-Hep has the potential as a novel scaffold material capable of delivering CGF, which can promote full-layer skin defect healing through a one-step strategy.
Stochastic parameter-shift rule for quantum metrology with general Hamiltonians
Authors: Ho Le Bin 
Published: June 2022

Abstract
Recently, quantum metrology with multiplicative Hamiltonians has been proposed in the variational quantum algorithms, from which the estimation precision can be adaptively optimized via the variational circuits. Systems with general Hamiltonians, however, still lack these variational schemes. This work introduces a quantum-circuit-based approach for studying quantum metrology with general Hamiltonians. We present a stochastic parameter-shift rule for the derivatives of the evolved quantum state under the parameterized gates in the circuit, whereby the quantum Fisher information can be obtained. Here the parameters are those we wish to estimate. We find that our scheme can be executed in universal quantum computers under the family of parameterized gates. Moreover, in the examples of the magnetic field estimation, we show the consistency between the results obtained from the stochastic parameter-shift rule and the exact results, while the results obtained from the standard parameter-shift rule slightly deviate from the exact ones. Our work sheds new light on studying quantum metrology with general Hamiltonians using quantum circuit algorithms.
Methodology, Assessment and Application of Biotope Mapping for Urban Parks in China: A Case Study on Riverside Park, Yichang
Authors: Zhao Cong-cong , Yang Yu-qi , Hu Yuan-dong 
Published: June 2022

Abstract
China, like many other countries in the world, has declining biodiversity caused by urbanization. Urban parks are a patchwork of distinct biotopes and have significant conservation value for biodiversity. Biotope mapping is an essential tool for urban biodiversity conservation, ecological spatial planning and ecosystem management, however there are few studies on it in China. This study explores a practical scheme of biotope classification, assessment and application for urban parks. We updated a classification scheme which integrated vegetation structure to make it clearer and more appropriate for urban parks in factor selection and grade. To identify problems in the biotope, the assessment tool assessed biotope fragmentation and spontaneous vegetation diversity. The number of patches (NP), mean patch size (MPS) and fragmentation index (FI) were used to measure biotope fragmentation, and for species level we used the richness index and the Jaccard index. These methods were applied to Riverside Park, Yichang as a case study site to verify the applicability and explore methods for biodiversity conservation and restoration based on biotope mapping. The results show that this classification scheme has the potential to become a standard system for urban parks in China, according to the advantages of recognition of human activities and other species, wide applicability and easy learning. It is also shows that the evaluation method integreting fragmentation and diversity is feasible and reliable to identify the problems of biotope types, and practical strategies are developed according to the assessment results. Our findings provide guidance and reference for professionals on a new method to take urban biodiversity conservation and restoration from research to practice.