bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avaliação do comportamento térmico de compostagem de resíduos agroindustriais e agroflorestais
Authors: Silva Mateus Oliveira , Soares Cintia Araújo , Mota Paula Kelen Aviz , Silva Edivânio Araújo da , Melo Sulleyme de Almeida , Saraiva Eduarda Shafira Silva , Lacerda José Dantas Araújo , Mendes Ana Célia Almeida , Barbosa Francisco Raylan Sousa , Souza Áurea Izabel Aguiar Fonseca e 
Published: April 2022

O aumento do custo dos fertilizantes comerciais e a crescente poluição ambiental fazem do uso de resíduos orgânicos na agricultura uma opção atrativa do ponto de vista econômico devido a ciclagem de carbono e de nutrientes. Dessa forma, a compostagem surge como uma forma eficiente de se obter a biodegradação controlada dos resíduos de natureza orgânica. Nesse sentido, o presente trabalho objetivou analisar o comportamento da temperatura durante o processo de compostagem de diferentes tipos de materiais, resíduos agroindustriais e agroflorestais. O experimento foi realizado na Universidade Federal Rural da Amazônia – UFRA, campus Parauapebas entre 30 de outubro de 2018 e 30 de janeiro de 2019, as pilhas de compostagem foram montadas no viveiro de mudas, um galpão aberto com cobertura de sombrite. Os materiais da primeira composteira (Leira 1) foram esterco bovino não curtido + bagaço de cana de açúcar + restos de vegetais + serragem. A segunda composteira (Leira 2) esterco bovino não curtido + serrapilheira + serragem. Foi possível observar que nos primeiros 3 dias a temperatura da primeira Compostagem (Leira 1) se elevou rapidamente, caracterizando o início da atividade microbiana. Ao longo dos 90 dias as pilhas apresentaram odor devido as zonas com excesso de água e consequente anaerobiose, ou seja, o excesso da água não permitiu a passagem de oxigênio no composto. Na primeira etapa do processo da segunda compostagem (Leira 2) a temperatura máxima atingida foi de 32°C no 14° dia. A compostagem é uma alternativa que merece visibilidade sendo uma alternativa economicamente viável e ambientalmente sustentável.
Avaliação do grau de conhecimento dos cirurgiões-dentistas sobre o atendimento a pacientes oncológicos
Authors: Almeida Erica Rejane Borges , Jesus Ivanete Marçal de , Pereira Yamba Carla Lara 
Published: April 2022

As neoplasias estão entre as maiores causas de mortes humanas por doença. E o câncer de cabeça e pescoço é considerado como a principal neoplasias que afeta o Brasil. Durante o tratamento oncológico de pacientes com acometimento em cabeça e pescoço surgem várias manifestações bucais, e cabe ao cirurgião-dentista a intervenção. Por tanto tornou-se objetivo deste trabalho avaliar, por meio de perguntas, o conhecimento dos Cirurgiões-Dentistas sobre o tratamento a pacientes oncológicos, antes durante ou depois da intervenção quimio ou radioterápica, para assim verificar o grau de conhecimento dos profissionais para o cuidado com pacientes oncológicos. A pesquisa foi realizada com Cirurgiões-Dentistas que atuam na sua profissão seja em clínica particular ou privada por meio de formulário eletrônico enviado via grupos específicos através do aplicativo WhatsApp. Participaram da pesquisa 19 Cirurgiões-Dentistas, sendo a maioria especialistas em Ortodontia, Odontologia para Pacientes com Necessidades Especiais e Saúde Coletiva. Os dados obtidos foram computados e submetidos à análise estatística simples de quantificação. Como resultados, o estudo identificou percepção positiva de que os profissionais na área da Odontologia, não se sente preparados para atender paciente oncológicos. Conclui-se que os Cirurgiões-Dentistas não estão preparados para atender pacientes em tratamento oncológico, o resultado pesquisa confirmou falta de conhecimento entre os entrevistados.
Clinical case of cryptogenic sepsis disguised as lymphoproliferative disease
Authors: Baranovskaya I. B. , Kotivets K. A. , Sysoeva I. P. 
Published: April 2022

The article presents a clinical case of sepsis occurring under the “mask” of a lymphoproliferative disease.The purpose of the study is to substantiate the need to analyze the entire set of laboratory and clinical data for the interpretation of the results of automated analysis of biological fluids.Materials and methods. The study was conducted on the basis of the Clinical Regional Hospital No. 2 in Krasnodar (Russia). In dynamics, the ascitic fluid and blood samples of patient P. with suspected lymphoproliferative disease were analyzed on the Sysmex XN analyzer. The results of automated analysis of abdominal effusion were compared with the results of cytological studies, as well as other laboratory and clinical data. The informative value of leukocyte indicators of inflammation (neutrophil reactivity – Neut-RI, granularity of neutrophils – Neut-GI) obtained in the ‘CBC+Diff’ mode of the Sysmex XN analyzer for the diagnosis of sepsis has been established. According to the data obtained, the predictive value of the parameter of automated analysis of biological fluids HF-BF (high fluorescent mononuclear cells) in terms of differential diagnosis of benign/malignant nature of the effusion is probabilistic.Conclusion. To verify the diagnosis, it is necessary to take into account the full range of indicators of automated analysis of biological fluids, comparing them with clinical data, as well as the results of hematological and biochemical tests.
Association Between Lipoprotein(a) and Calcific Aortic Valve Disease: A Systematic Review and Meta-Analysis
Authors: Liu Qiyu , Yu Yanqiao , Xi Ruixi , Li Jingen , Lai Runmin , Wang Tongxin , Fan Yixuan , Zhang Zihao , Xu Hao , Ju Jianqing 
Published: April 2022

BackgroundPreliminary studies indicated that enhanced plasma levels of lipoprotein(a) [lp(a)] might link with the risk of calcific aortic valve disease (CAVD), but the clinical association between them remained inconclusive. This systematic review and meta-analysis were aimed to determine this association.MethodsWe comprehensively searched PubMed, Embase, Web of Science, and Scopus databases for studies reporting the incidence of CAVD and their plasma lp(a) concentrations. Pooled risk ratio (RR) and 95% confidence interval (95% CI) were calculated to evaluate the effect of lp(a) on CAVD using the random-effects model. Subgroup analyses by study types, countries, and the level of adjustment were also conducted. Funnel plots, Egger's test and Begg's test were conducted to evaluate the publication bias.ResultsEight eligible studies with 52,931 participants were included in this systematic review and meta-analysis. Of these, four were cohort studies and four were case-control studies. Five studies were rated as high quality, three as moderate quality. The pooled results showed that plasma lp(a) levels ≥50 mg/dL were associated with a 1.76-fold increased risk of CAVD (RR, 1.76; 95% CI, 1.47–2.11), but lp(a) levels ≥30 mg/dL were not observed to be significantly related with CAVD (RR, 1.28; 95% CI, 0.98–1.68). We performed subgroup analyses by study type, the RRs of cohort studies revealed lp(a) levels ≥50 mg/dL and lp(a) levels ≥30 mg/dL have positive association with CAVD (RR, 1.70; 95% CI, 1.39–2.07; RR 1.38; 95% CI, 1.19–1.61).ConclusionHigh plasma lp(a) levels (≥50 mg/dL) are significantly associated with increased risk of CAVD.
Comparative Evaluation of Chiglitazar and Sitagliptin on the Levels of Retinol-Binding Protein 4 and Its Correlation With Insulin Resistance in Patients With Type 2 Diabetes
Authors: Zhou Yunting , Wang Huiying , Wang Yuming , Xu Xiaohua , Li Fengfei , Zhou Junming , Shan Ting , Huang Rong , Cai Tingting , Liu Xiaomei , Su Xiaofei , Li Huiqin , Ma Jianhua 
Published: April 2022

AimsWe evaluated the efficacy and significant changes in the levels of retinol-binding protein 4 (RBP-4) and insulin resistance in patients with type 2 diabetes mellitus (T2DM) treated with chiglitazar versus sitagliptin.MethodsEighty-one T2DM patients with haemoglobin A1c (HbA1c) level of 7.5%–10.0% were selected. Based on the study criteria, patients were randomly assigned to receive chiglitazar (32 mg), chiglitazar (48 mg), or sitagliptin (100 mg) orally for 24 weeks. Sociodemographic and anthropometric characteristics, lipid profiles, glucose profiles, and serum RBP-4 levels were determined at baseline and at the end of the therapy.ResultsAfter treatment for 24 weeks, significant changes in fasting blood glucose (FBG), fasting insulin (Fins), 2 h-blood glucose (2h-BG), the score values of insulin resistance/insulin secretion/β cell function (HOMA-IR, HOMA-IS, and HOMA-β), triglyceride (TG), free fatty acid (FFA), high-density lipoprotein cholesterol (HDL-C), and RBP-4 levels were detected in patients with chiglitazar administration and sitagliptin administration. Changes in RBP-4 levels were positively correlated with changes in HOMA-IR and 2 h-BG in linear regression.ConclusionsChiglitazar showed a greater improvement in parameters of diabetes than sitagliptin, and changes in serum RBP-4 levels were associated with changes in insulin-sensitizing parameters.Clinical Trial RegistrationClinicalTrials.gov, CT.gov identifier: NCT02173457.
Outcome of Endoscopic Transsphenoidal Surgery for Recurrent or Residual Pituitary Adenomas and Comparison to Non-Recurrent or Residual Cohort by Propensity Score Analysis
Authors: Gong Xuan , Zhuo Yang , Yuan Huichun , Yang Kui , Li Chuntao , Feng Songshan , Zhang Mingyu , Li Zhenyan , Zhou Hongshu , Liu Zhixiong 
Published: April 2022

ObjectiveTo evaluate the long-term outcomes and safety of endoscopic transsphenoidal surgery (ETS) in recurrent and residual pituitary adenomas (rrPAs), as well as the predictors of gross total resection (GTR) and intraoperative CSF leakage. Furthermore, to compare outcomes and complications with non-rrPAs cohort.MethodsClinical and radiological characteristics of patients with rrPAs who underwent ETS were collected between 2017 and 2020. Data of patients with non-rrPAs were collected from 2019 to 2020. Logistic regression analyses were performed to investigate the factors influencing gross total resection (GTR) and intraoperative CSF leakage. Between-group comparisons of outcomes and complications were performed through propensity score analysis.ResultsWe enrolled 73 patients with rrPAs. GTR was achieved in 41 (56.1%) cases; further, GTR or near-total resection was achieved in 93.2% of patients. The mean tumor volumes for GTR and non-GTR cases were 6.2 ±7.2 cm3 and 11.1 ±9.1 cm3, respectively. Multivariate regression analysis of the GTR rate in patients with rrPAs revealed that Knosp grade was an independent factor (odds ratio [OR] = 0.324; p=0.005). Moreover, previous transcranial surgery and non-functional pituitary adenomas were risk factors for intraoperative CSF leakage in patients with rrPAs (OR=6.450, p=0.019 and OR=7.472, p=0.012, respectively). After propensity score matching, There was no significant difference in the GTR rate between patients with rrPAs and patients with non-rrPAs. Contrastingly, patients with rrPAs had a higher rate of intraoperative CSF leakage and longer postoperative hospital stay than patients with non-rrPAs. During the follow-up, vision improved in 9 (22.0%) and 24 (62.5%) patients with rrPAs and non-rrPAs, respectively. Although there was a trend that reoperation of rrPAs involved a lower hypopituitarism recovery rate and biochemical remission rate, as well as a higher hypopituitarism rate, there was no statistically significant between-group difference.ConclusionsKnosp grade was an independent factor for GTR in endoscopic transsphenoidal surgery in patients with rrPAs. Previous transcranial surgery and non-functional PAs were risk factors for intraoperative CSF leakage. Although associated with longer hospital stay, rrPAs did not associate with lower GTR rate or more frequent postoperative complications than non-rrPAs cohort.
Comprehensive Analyses of Mutation-Derived Long-Chain Noncoding RNA Signatures of Genome Instability in Kidney Renal Papillary Cell Carcinoma
Authors: Li Jian , Wei Shimei , Zhang Yan , Lu Shuangshuang , Zhang Xiaoxu , Wang Qiong , Yan Jiawei , Yang Sanju , Chen Liying , Liu Yunguang , Huang Zhijing 
Published: April 2022

Background: The role of long-chain noncoding RNA (lncRNA) in genomic instability has been demonstrated to be increasingly importance. Therefore, in this study, lncRNAs associated with genomic instability were identified and kidney renal papillary cell carcinoma (KIRP)-associated predictive features were analysed to classify high-risk patients and improve individualised treatment.Methods: The training (n = 142) and test (n = 144) sets were created using raw RNA-seq and patient’s clinical data of KIRP obtained from The Cancer Genome Atlas (TCGA).There are 27 long-chain noncoding RNAs (lncRNAs) that are connected with genomic instability, these lncRNAs were identified using the ‘limma’ R package based on the numbers of somatic mutations and lncRNA expression profiles acquired from KIRP TCGA cohort. Furthermore, Cox regression analysis was carried out to develop a genome instability-derived lncRNA-based gene signature (GILncSig), whose prognostic value was confirmed in the test cohort as well as across the entire KIRP TCGA dataset.Results: A GILncSig derived from three lncRNAs (BOLA3-AS1, AC004870, and LINC00839), which were related with poor KIRP survival, was identified, which was split up into high- and low-risk groups. Additionally, the GILncSig was found to be an independent prognostic predictive index in KIRP using univariate and multivariate Cox analysis. Furthermore, the prognostic significance and characteristics of GilncSig were confirmed in the training test and TCGA sets. GilncSig also showed better predictive performance than other prognostic lncRNA features.Conclusion: The function of lncRNAs in genomic instability and the genetic diversity of KIRP were elucidated in this work. Moreover, three lncRNAs were screened for prediction of the outcome of KIRP survival and novel insights into identifying cancer biomarkers related to genomic instability were discussed.
Semi-Active Controllable Stiffness Engine Mount Utilizing Natural Rubber-Based Magnetorheological Elastomers
Authors: Mat Song Rusdi , Mazlan Saiful Amri , Johari Norhasnidawani , Imaduddin Fitrian , Abdul Aziz Siti Aishah , Abd Fatah Abdul Yasser , Ubaidillah U. 
Published: April 2022

This study proposes the design and fabrication of a natural rubber-based magnetorheological elastomer (NR-MRE) engine mount as a new device in absorbing the vibration originated from the automotive engine. The conceptual design was performed through a simulation process by Finite Element Method Magnetics to analyze the magnetic field distribution. The simulation result had indicated that the device was capable of generating an equivalent magnetic field density of 0.31 T at the effective area. The MRE was prepared by utilizing 60 wt% of carbonyl iron particles (CIPs), and the cavity was filled by compression molding. The MRE compound was tested based on its basic mechanical properties, while the MRE engine mounts were tested under a static compression load at off- and on-state conditions. It was observed that the compound possessed a good tensile strength for a load bearer matrix with an average of 12.65 MPa. Subsequently, the results of the static compression load had showed that the MRE engine mounts recorded an increase of 12% in the force generated as compared to conventional engine mounts at an off-state condition. Meanwhile, at an on-state condition of 2.4 A, the MRE engine mounts recorded an increase in the force generated with 106%. The study has demonstrated that the proposed device can be one of the potential candidates for vibration control applications due to its stiffness controllability.
Different Surgical Approaches for Early-Stage Ovarian Cancer Staging. A Large Monocentric Experience
Authors: Cianci Stefano , Capozzi Vito Andrea , Rosati Andrea , Rumolo Valerio , Corrado Giacomo , Uccella Stefano , Gueli Alletti Salvatore , Riccò Matteo , Fagotti Anna , Scambia Giovanni , Cosentino Francesco 
Published: April 2022

IntroductionOvarian cancer is the third most frequent gynecological cancer. In early stage ovarian cancer (ESOC) comprehensive surgical staging is recommended. Surgical staging is traditionally approached by laparotomy, although minimally invasive surgery can be a valid alternative in selected patients. This study aims to analyze the surgical and oncological outcomes of three different surgical approaches in a large series of patients.MethodsWe retrospectively included all histologically proven ESOC cases treated between January 2014 and December 2017. ESOC was defined as stage IA to IIB according to the 2018 FIGO staging system. Subjects were divided into groups 1, 2, and 3, based on the surgical approach (open abdominal, laparoscopic, or robotic, respectively).ResultsWithin patients enrolled during the study period, 455 met the inclusion criteria. No difference in intraoperative complications was recorded in the three groups (p = 0.709). Conversely, a significant difference occurred in postoperative complications (16.2 vs. 3.8 vs. 11.1%, in groups 1, 2, and 3 respectively, p = 0.004). No difference was found in overall survival (OS) (32 vs. 31 vs. 25 months, p = 0.481) and disease-free survival (DFS) (26 vs. 29 vs. 24 months, p = 0.178) in groups 1, 2, and 3, respectively. At univariate analysis FIGO stage I (p = 0.004) showed a lower recurrence rate compared to FIGO stage II.ConclusionNo significant difference was found in OS and DFS among the three groups (open, laparoscopic, and robotic). The minimally invasive approach showed lower rate of complications than the laparotomic approach.
The Comparative Efficacy of Non-ergot Dopamine Agonist and Potential Risk Factors for Motor Complications and Side Effects From NEDA Use in Early Parkinson's Disease: Evidence From Clinical Trials
Authors: Wu Chunxiao , Guo Hongji , Xu Yingshan , Li Luping , Li Xinyu , Tang Chunzhi , Chen Dongfeng , Zhu Meiling 
Published: April 2022

Background/ObjectivesNon-ergot dopamine agonist (NEDA) are recommended as the first-line treatment for patients with early Parkinson's disease (PD) because of their efficacy in treating PD motor symptoms. However, systematic evaluations of the risk of motor complications induced by NEDA and risk factors potentially associated with motor complications are still lacking.MethodsMedline, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science were searched for potentially eligible randomized controlled trials. The incidence of motor complications (dyskinesia, motor fluctuations), impulsive-compulsive behaviors and adverse events and clinical disability rating scale (UPDRS) scores were evaluated using standard meta-analytic methods. Metaregression was conducted on the incidence of motor complications (dyskinesia) with treatment duration and NEDA dose as covariates.ResultsPatients treated with NEDA had significantly lower UPDRS total scores, motor scores and activity of daily living (ADL) scores than those receiving a placebo (weighted mean difference (WMD) −4.81, 95% CI −6.57 to −3.05; WMD −4.901, 95% CI −7.03 to −2.77; WMD −1.52, 95% CI −2.19 to −0.84, respectively). Patients in the NEDA and NEDA+open Levodopa (LD) groups had lower odds for dyskinesia than patients in the LD group (OR = 0.21, 95% CI: 0.15–0.29; OR = 0.31, 95% CI 0.24–0.42, respectively). Metaregressions indicated that the mean LD dose of the NEDA group increased, and the odds of developing dyskinesia increased (p = 0.012). However, the odds of developing dyskinesia in the NEDA group were not related to treatment duration (p = 0.308). PD patients treated with NEDA or NEDA+open LD had a lower risk of wearing-off implications than those treated with LD (all p &lt; 0.05). No significant difference was found between the NEDA and placebo groups in impulsive-compulsive behavior development (p &gt; 0.05). Patients in the NEDA group were more likely to suffer somnolence, edema, constipation, dizziness, hallucinations, nausea and vomiting than those in the placebo or LD group.ConclusionNEDA therapy reduces motor symptoms and improves ADLs in early PD. The odds of developing motor complications were lower with NEDA than with LD, and dyskinesia increased with increasing LD equivalent dose and was not influenced by NEDA treatment duration. Therefore, long-term treatment with an appropriate dosage of NEDA might be more suitable than LD for early PD patients.RegistrationPROSPERO CRD42021287172.
Practice Effects in Mild Cognitive Impairment Increase Reversion Rates and Delay Detection of New Impairments
Authors: Sanderson-Cimino Mark , Elman Jeremy A. , Tu Xin M. , Gross Alden L. , Panizzon Matthew S. , Gustavson Daniel E. , Bondi Mark W. , Edmonds Emily C. , Eppig Joel S. , Franz Carol E. , Jak Amy J. , Lyons Michael J. , Thomas Kelsey R. , Williams McKenna E. , Kremen William S. 
Published: April 2022

ObjectiveCognitive practice effects (PEs) can delay detection of progression from cognitively unimpaired to mild cognitive impairment (MCI). They also reduce diagnostic accuracy as suggested by biomarker positivity data. Even among those who decline, PEs can mask steeper declines by inflating cognitive scores. Within MCI samples, PEs may increase reversion rates and thus impede detection of further impairment. Within an MCI sample at baseline, we evaluated how PEs impact prevalence, reversion rates, and dementia progression after 1 year.MethodsWe examined 329 baseline Alzheimer’s Disease Neuroimaging Initiative MCI participants (mean age = 73.1; SD = 7.4). We identified test-naïve participants who were demographically matched to returnees at their 1-year follow-up. Since the only major difference between groups was that one completed testing once and the other twice, comparison of scores in each group yielded PEs. PEs were subtracted from each test to yield PE-adjusted scores. Biomarkers included cerebrospinal fluid phosphorylated tau and amyloid beta. Cox proportional models predicted time until first dementia diagnosis using PE-unadjusted and PE-adjusted diagnoses.ResultsAccounting for PEs increased MCI prevalence at follow-up by 9.2% (272 vs. 249 MCI), and reduced reversion to normal by 28.8% (57 vs. 80 reverters). PEs also increased stability of single-domain MCI by 12.0% (164 vs. 147). Compared to PE-unadjusted diagnoses, use of PE-adjusted follow-up diagnoses led to a twofold increase in hazard ratios for incident dementia. We classified individuals as false reverters if they reverted to cognitively unimpaired status based on PE-unadjusted scores, but remained classified as MCI cases after accounting for PEs. When amyloid and tau positivity were examined together, 72.2% of these false reverters were positive for at least one biomarker.InterpretationEven when PEs are small, they can meaningfully change whether some individuals with MCI retain the diagnosis at a 1-year follow-up. Accounting for PEs resulted in increased MCI prevalence and altered stability/reversion rates. This improved diagnostic accuracy also increased the dementia-predicting ability of MCI diagnoses.