bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intra‐aortic balloon pump in cardiogenic shock: A propensity score matching analysis
Authors: Yuan Sheng , He Jining , Cai Zhongxing , Zhang Rui , Song Chenxi , Qiao Zheng , Song Weihua , Feng Lei , Dou Kefei 
Published: January 2022

AbstractObjectiveTo assess the impact of intra‐aortic balloon pumps (IABP) on patients with cardiogenic shock in an intensive care unit setting.BackgroundIABP counterpulsation is a widely used mechanical circulatory support device, but its performance has been questioned. However, current evidence of IABP use in cardiogenic shock is very limited (mainly from the IABP‐SHOCK II trial), which was restricted to cardiogenic shock complicating acute myocardial infarction.MethodsThis was a retrospective, real‐world, cohort study based on the Medical Information Mart for Intensive Care III database. Adult patients with a diagnosis of cardiogenic shock were eligible.ResultsA total of 1028 patients with cardiogenic shock were assessed, including 384 patients who received IABP and 644 patients who did not. The in‐hospital mortality was significantly lower in patients who received IABP (adjusted odds ratio: 0.75, 95% confidence interval: 0.62–0.91, p = 0.009). Analysis of secondary endpoints found that the use of IABP was associated with a significantly lower risk of 1‐year mortality. After propensity score matching, the in‐hospital mortality remained significantly lower in the IABP group (28.10% vs. 37.59%, p = 0.018).ConclusionsIn the current cohort, IABP treatment was associated with a lower risk of in‐hospital mortality in patients with cardiogenic shock. Due to the complexity of pathophysiology in cardiogenic shock and the discrepancies in current evidence, our results should be validated through further studies in the future.
Extraction and replantation of a periapically infected tooth
Authors: Flanagan Dennis 
Published: January 2022

AbstractAt times, an infected tooth that may be deemed unrestorable may be salvaged by atraumatic removal, an in‐hand apicoectomy and retrograde seal, then replantation. This patient was referred to this author for an extraction and implant treatment of the maxillary left second premolar. After a discussion, the patient preferred to salvage the tooth if possible. The tooth was successfully atraumatically removed, and an in‐hand apicoectomy and retrograde amalgam seal was placed. The tooth was immediately replaced into its socket and was stable. The occlusal surface was flattened to prevent and off axial loading. A bis‐acryl brace was applied to the facial and lingual aspect to prevent an overload while the tooth was healing. The patient was admonished to maintain a soft diet. After 3 weeks, the braces were removed, and the tooth was found to be stable. After 8 weeks, the tooth was asymptomatic, and the patient was able to revert to her normal diet without pain. While extraction, placing an apical seal and replantation of teeth is not a new modality; nonetheless, clinicians may need to be reminded of this procedure to increase the number of options presented to patients.
Radiological features of Adenomatoid odontogenic tumor: Report of a maxillary case and a mandibular one
Authors: Chaabani Imen , Bouguila Jed , Kammoun Rym , Chebbi Raja , Sriha Badreddine , Khochteli Habib , Ben Alaya Touhami 
Published: January 2022

AbstractWe present two cases of AOT, the first case concerns a 23‐year‐old patient with an AOT located in the maxilla and the second case involves a 37‐year‐old patient presenting an AOT with mandibular localization.
Maximizing soybean productivity and profitability by transitioning from flood to furrow irrigation on clay‐textured soils
Authors: Bryant Corey J. , Krutz L. Jason , Spencer G. Dave , Mills Brian E. 
Published: January 2022

AbstractThe type of irrigation delivery system used in the mid‐southern United States can have an effect on crop–water relationships and withdrawal from the Mississippi River Valley Alluvial Aquifer. This study was conducted to determine whether converting from flood irrigation to an optimized furrow irrigation delivery system improves soybean [Glycine max (L.) Merr.] grain yield, net returns, and irrigation water use efficiency (IWUE). The effects of flood and optimized furrow irrigation on soybean grain yield, net returns above specified costs, irrigation water applied, and IWUE were investigated from 2016 to 2018 on 24 paired fields with the same soil type, cultivar, planting date, and management practices in the Delta region of Mississippi. Transitioning from flood irrigation to an optimized furrow irrigation system increased soybean grain yield by 7% and net returns above specified costs by 18% but had no effect on consumptive water use or IWUE. Our data indicate that mid‐southern US soybean producers should convert from flood to optimized furrow irrigation systems to maximize soybean grain yield and net returns; however, switching between irrigation delivery systems will have no effect on aquifer decline
Glyoxal‐Linked Nucleotides and DNA for Bioconjugations and Crosslinking with Arginine‐Containing Peptides and Proteins
Authors: Leone Denise‐Liu' , Pohl Radek , Hubálek Martin , Kadeřábková Marta , Krömer Matouš , Sýkorová Veronika , Hocek Michal 
Published: January 2022

AbstractGlyoxal‐linked 2’‐deoxyuridine 5’‐O‐mono‐ and triphosphates were synthesized through a CuAAC click reaction of 4‐azidophenylglyoxal or a Sonogashira reaction of 4‐bromophenylglyoxal with 5‐ethynyl‐dUMP or ‐dUTP. The triphosphates were used as substrates for enzymatic synthesis of modified DNA probes with KOD XL DNA polymerase. The glyoxal‐linked nucleotides reacted with arginine‐containing peptides to form stable imizadolone‐linked conjugates. This reactive glyoxal modification in DNA was used for efficient bioconjugations and crosslinking with Arg‐containing peptides or proteins (e. g., histones) and was found to be more reactive than previously reported 1,3‐diketone‐linked DNA probes.
Pd/Ag Nanoparticles Prepared in Ionic Liquids as Model Catalysts for the Hydrogenation of Diphenylacetylene
Authors: Uzunidis Georgios , Behrens Silke 
Published: January 2022

AbstractThe preparation of bimetallic Pd/Ag‐based model catalysts is addressed to study the promotional effects of Ag doping in the liquid‐phase semi‐hydrogenation of diphenylacetylene. The precursor concept is employed where colloidal bimetallic Pd/Ag nanoparticles are initially synthesized and then used as well‐defined building units for catalyst preparation. This approach allows for tuning the composition of the nanoparticles independently with the two metals co‐localized to a fine extent. Size and composition of the nanoparticles are preserved after immobilizing them on a carbon support.
Flexible Etherified and Esterified Triphenylethylene Derivatives and Their Evaluation on ER‐positive and Triple‐Negative Breast Cancer Cell Lines
Authors: Hassan Aya S. , Wober Jannette , Vollmer Günter , Abadi Ashraf H. , Ahmed Nermin S. 
Published: January 2022

AbstractTamoxifen (TAM) is a selective estrogen receptor modulator (SERM) with potential clinical benefits for all stages of breast cancer. TAM is primarily metabolized to more potent metabolites via polymorphic CYP2D6. This affects the clinical outcome of TAM treatment. Herein we report novel TAM analogues that can avoid metabolism via CYP2D6. The novel analogues bear a flexible skeleton. Compounds have either an ester group on ring C or homodiaminoalkoxy groups on rings B and C. Compound 6 (E/Z‐4‐[1‐[4‐(2‐diethylaminoethoxy)phenyl]‐3‐(4‐methoxyphenyl)‐2‐methyl[propenyl]phenol) was found to be ten‐fold more potent than TAM on MCF‐7 cells (GI50=0.15 μM). It showed fivefold greater inhibitory activity on MDA‐MB‐231 cells than TAM (GI50=1.71 μM). Compound 13 (4‐{3,3‐bis‐[4‐(3‐dimethylaminopropoxy)phenyl]‐2‐methylallyl}methoxybenzene) was the most potent among the homodiaminoalkoxy derivatives (GI50=0.44) on both MCF‐7 and MDA‐MB‐231 cell lines, respectively. Furthermore, the COMPARE algorithm suggested that it has different molecular targets from those of some other reported anticancer drugs.
Verrucous carcinoma of the vulva: Patterns of care and treatment outcomes
Authors: Dryden Sara M. , Reshko Leonid B. , Gaskins Jeremy T. , Silva Scott R. 
Published: January 2022

AbstractBackgroundVerrucous vulvar carcinoma (VC) is an uncommon and distinct histologic subtype of squamous cell carcinoma (SCC). The available literature on VC is currently limited to case reports and small single institution studies.AimsThe goals of this study were to analyze data from the National Cancer Database (NCDB) to quantitate the incidence of VC and to investigate the effects of patient demographics, tumor characteristics, and treatment regimens on overall survival (OS) in women with verrucous vulvar carcinoma.Methods and resultsPatients diagnosed with vulvar SCC or VC between the years of 2004 and 2016 were identified in the NCDB. OS was assessed with Kaplan–Meier curves and the log‐rank test. Construction of a Cox model compared survival after controlling for confounding variables. The reported incidence of SCC of the vulva has significantly increased since 2004 (p < .0001). In contrast, the incidence of VC has remained stable (p = .344) since 2004. Compared to SCC, VC was significantly more likely to be diagnosed in older women (p < .0001) and treated with surgery alone (p < .0001). However, on propensity score weighted analysis there was a trend toward improved 5‐year OS in women with VC compared to those with SCC (63.4% vs. 57.7%, p = .0794). Multivariable Cox survival analysis showed an improvement in OS in VC patients treated with both primary site and regional lymph node surgery compared to primary site surgery alone (adjusted hazard ratio [aHR] 0.67, 95% confidence interval [CI] 0.46–0.97, p = .0357).ConclusionVerrucous carcinoma is more likely to present in older women. Regional lymph node surgery in addition to primary site surgery significantly improves OS in VC patients.
KubFBS: A fine‐grained and balance‐aware scheduling system for deep learning tasks based on kubernetes
Authors: Liu Zijie , Chen Can , Li Junjiang , Cheng Yi , Kou Yingjie , Zhang Dengyin 
Published: January 2022

AbstractThe past decade witnessed a remarkable increase in deep learning (DL) workloads which require GPU resources to accelerate the training process. However, the existing coarse‐grained scheduling mechanisms are agnostic to information other than the number of GPUs or GPU memory, which results in performance degradation of DL tasks. Moreover, the common assumption held by the existing balance‐aware DL task scheduling strategies, a DL task consumes resources once it starts, fails to reduce resource contention, and further limits execution efficiency. To address these problems, this article proposes a fine‐grained and balance‐aware scheduling model (FBSM) which considers the resource consumption characteristic of the DL task. Based on FBSM, we propose customized GPU sniffer (GPU‐S) and balance‐aware scheduler (BAS) modules to construct a scheduling system called KubFBS. The experimental results demonstrate KubFBS accelerates the execution of DL tasks while improving the load balancing capability of the cluster.
Subversion of infiltrating prostate macrophages to a mixed immunosuppressive tumor‐associated macrophage phenotype
Authors: Boibessot Clovis , Molina Oscar , Lachance Gabriel , Tav Christophe , Champagne Audrey , Neveu Bertrand , Pelletier Jean‐François , Pouliot Frédéric , Fradet Vincent , Bilodeau Steve , Fradet Yves , Bergeron Alain , Toren Paul 
Published: January 2022

AbstractTumor‐associated macrophages (TAMs) support tumor progression within the tumor microenvironment (TME). Many questions remain as to the origin, development, and function of TAMs within the prostate TME. Evaluation of TAMs in prostate cancer (PCa) patients identified the immunosuppressive TAM marker CD163 in adjacent normal epithelium as an independent predictor of metastases or PCa death. Flow cytometry analyses identified prostate TAMs as frequently expressing both proinflammatory M1 (CCR7+) and immunosuppressive M2 (CD163+) markers. In vitro, we demonstrate PCa cells similarly subvert human M1 macrophages toward a mixed M1/M2 macrophage phenotype favoring tumor growth. Further the cytokine milieu‐induced transition between immunosuppressive M2 to proinflammatory M1 (M2→M1) macrophages is abrogated by the presence of PCa cells. RNA sequencing suggests alterations in chemokine expression in prostate TAMs due to the presence of PCa cells. Together, our results suggest that prostate TAMs originate from inflammatory infiltrating macrophages, which are then reprogrammed mainly by PCa cells, but also the cytokine milieu. A better understanding of this subversion of macrophages within the prostate may lead to novel treatment strategies.
Ferrocenyl Gold Complexes as Efficient Catalysts
Authors: Pérez‐Sánchez Juan Carlos , Herrera Raquel P. , Gimeno M. Concepción 
Published: January 2022

AbstractMore than half a century after the discovery of the ferrocene structure in 1951, it remains as a suitable building block in many research areas, including catalysis with the development of key chiral catalysts. On the other hand, gold‐mediated catalysis has been raised in recent years, allowing the creation of a great variety of C−C bonds and C‐heteroatom bonds. In this context, this review covers the recent advances made with the combination of these two iconic figures in the organometallic chemistry field, since the first gold catalyzed reaction using a ferrocene ligand reported in 1986. The combination of the excellent properties and versatility of this metallocene, has allowed the obtainment of a plethora of ligands for metal catalysis, although their use joined to gold catalysis is still scarcely explored.
Low‐Cost Transition Metal‐Catalyzed Heck‐Type Reactions: An Overview
Authors: Alisha Mathews , Philip Rose Mary , Anilkumar Gopinathan 
Published: January 2022

AbstractHeck coupling has emerged as an effective and powerful tool for C−C bond formations, with applications in academic and industrial grounds. The conventional Mizoroki‐Heck reaction employed expensive Pd based catalysts, however, developments to meet low‐cost replacements to Pd is relevant from a sustainable point of view. Heck‐type couplings involving cost‐effective transition metals such as Fe, Co, Ni, and Cu have been established in the recent decades. Herein, we have comprehended the developments in low‐cost transition metal‐catalyzed Heck couplings covering the literature from 2016.
Exploration of nanozymes in viral diagnosis and therapy
Authors: Lee Jiyoung , Liao Hongwei , Wang Qiyue , Han Jieun , Han Jun‐Hyeok , Shin Ha Eun , Ge Minghua , Park Wooram , Li Fangyuan 
Published: January 2022

AbstractNanozymes are nanomaterials with similar catalytic activities to natural enzymes. Compared with natural enzymes, they have numerous advantages, including higher physiochemical stability, versatility, and suitability for mass production. In the past decade, the synthesis of nanozymes and their catalytic mechanisms have advanced beyond the simple replacement of natural enzymes, allowing for fascinating applications in various fields such as biosensing and disease treatment. In particular, the exploration of nanozymes as powerful toolkits in diagnostic viral testing and antiviral therapy has attracted growing attention. It can address the great challenges faced by current natural enzyme‐based viral testing technologies, such as high cost and storage difficulties. Therefore, nanozyme can provide a novel nanozyme‐based antiviral therapeutic regime with broader availability and generalizability that are keys to fighting a pandemic such as COVID‐19. Herein, we provide a timely review of the state‐of‐the‐art nanozymes regarding their catalytic activities, as well as a focused discussion on recent research into the use of nanozymes in viral testing and therapy. The remaining challenges and future perspectives will also be outlined. Ultimately, this review will inform readers of the current knowledge of nanozymes and inspire more innovative studies to push forward the frontier of this field.
Differential Orthopedia Homeobox expression in pulmonary carcinoids is associated with changes in DNA methylation
Authors: Moonen Laura , Mangiante Lise , Leunissen Daphne J. G. , Lap Lisa M. V. , Gabriel Aurelie , Hillen Lisa M. , Roemen Guido M. , Koch Alexander , van Engeland Manon , Dingemans Anne‐Marie C. , Foll Matthieu , Alcala Nicolas , Fernandez‐Cuesta Lynnette , Derks Jules L. , Speel Ernst‐Jan M. 
Published: January 2022

AbstractLimited number of tumor types have been examined for Orthopedia Homeobox (OTP) expression. In pulmonary carcinoids, loss of expression is a strong indicator of poor prognosis. Here, we investigated OTP expression in 37 different tumor types, and the association between OTP expression and DNA methylation levels in lung neuroendocrine neoplasms. We analyzed publicly available multi‐omics data (whole‐exome‐, whole‐genome‐, RNA sequencing and Epic 850K‐methylation array) of 58 typical carcinoids, 27 atypical carcinoids, 69 large cell neuroendocrine carcinoma and 51 small cell lung cancer patients and TCGA (The Cancer Genome Atlas) data of 33 tumor types. 850K‐methylation analysis was cross‐validated using targeted pyrosequencing on 35 carcinoids. We report bimodality of OTP expression in carcinoids (OTPhigh vs OTPlow group, likelihood‐ratio test P = 1.5 × 10−2), with the OTPhigh group specific to pulmonary carcinoids while absent from all other cohorts analyzed. Significantly different DNA methylation levels were observed between OTPhigh and OTPlow carcinoids in 12/34 OTP infinium probes (FDR < 0.05 and β‐value effect size > .2). OTPlow carcinoids harbor high DNA methylation levels as compared to OTPhigh carcinoids. OTPlow carcinoids showed a significantly worse overall survival (log‐rank test P = .0052). Gene set enrichment analysis for somatically mutated genes associated with hallmarks of cancer showed robust enrichment of three hallmarks in the OTPlow group, that is, sustaining proliferative signaling, evading growth suppressor and genome instability and mutation. Together our data suggest that high OTP expression is a unique feature of pulmonary carcinoids with a favorable prognosis and that in poor prognostic patients, OTP expression is lost, most likely due to changes in DNA methylation levels.
Clinical characteristics and surgical management of endometriosis‐associated infertility: A multicenter prospective cohort study
Authors: Bhurke Aishwarya V. , DasMahapatra Pramathes , Balakrishnan Sheila , Khan Shagufta A. , Mortlock Sally , Das Vinita , Chellamma Nirmala , Cheruvara Vadakkathil Sowmini , Srivastava Aarti , Majumdar Amiya , Pasi Achhelal , Sachdeva Geetanjali , Montgomery Grant W. , Gajbhiye Rahul K. 
Published: January 2022

AbstractObjectiveTo study clinical, surgical characteristics and the relationship between endometriosis lesion types and conception rate after surgery in infertile women with endometriosis.MethodsA prospective, multicenter cohort of 204 women (age 20–35 years) with endometriosis was followed up post‐surgery between November 2017 and February 2020 at three tertiary‐care hospitals.ResultsBased on the severity of endometriosis lesion type, deep infiltrating endometriosis (DIE) (81/204, 39.7%) was the most common lesion; followed by ovarian endometriosis (OMA) (64/204, 31.4%), and superficial peritoneal endometriosis (SUP) (59/204, 28.9%). Endometriosis patients had a single lesion type (94/204, 46.1%), two lesion types (77/204, 37.7%), or three lesion types (33/204, 16.2%) with significant differences between regions (P < 0.001). Around 40% (37/95) of obese women had SUP (P = 0.003) whereas 78% (14/18) of underweight women had DIE (P < 0.001). Significant differences in mean Endometriosis Fertility Index scores between endometriosis lesion types and patients with one, two, and three types of lesions were observed (P < 0.001). The majority (22/32, 68.8%) of the women conceived naturally after the surgery. Half (16/32; 50%) of the women with a single lesion type conceived after the surgery; of which most (13/16, 81.2%) had SUP, followed by OMA (2/16, 12.5%), and DIE (1/16, 6.3%).ConclusionWomen with SUP and only one type of endometriotic lesion were more likely to conceive post‐surgery.
Prioritization of areas suitable for rice cultivation based on the economic value of irrigation water
Authors: Rezaei Golaz , Khaledian Mohammadreza , Kavoosi‐Kalashami Mohammad , Rezaei Mojtaba 
Published: January 2022

AbstractThis study assessed the economic value of rice irrigation water in four key rice‐producing provinces of Iran: Guilan, Mazandaran, Khuzestan and Fars. In this respect, the production function approach and cross‐section data of 2014–2015, collected from paddy farmers in each province, were applied. In this research, two approaches were used: (i) determining the economic value of irrigation water after omitting outliers and extreme observations (first approach); (ii) determining the economic value of rice irrigation water using relevant observations that match the yield–input consumption trend equation (second approach). The results of the first and second approaches showed that Guilan province was ranked first in terms of economic value of rice irrigation water with average economic values of US$0.47 and 0.53, Mazandaran ranked second with average economic values of US$0.35 and 0.32, Khuzestan province ranked third with US$0.17 and 0.16 and Fars province ranked fourth with US$0.09 and 0.09, respectively. Therefore, it is recommended that farmers cultivate rice in the two first provinces that enjoy enough water and, also, in the two last provinces limit the scope of their cultivation because of water scarcity. This methodology can be employed in other regions to prioritize areas suitable for rice cultivation.
Second‐order asymmetric convolution network for breast cancer histopathology image classification
Authors: Hou Cunqiao , Li Jiasen , Wang Wei , Sun Lin , Zhang Jianxin 
Published: January 2022

AbstractRecently, convolutional neural networks (CNNs) have been widely utilized for breast cancer histopathology image classification. Besides, research works have also convinced that deep high‐order statistic models obviously outperform corresponding first‐order counterparts in vision tasks. Inspired by this, we attempt to explore global deep high‐order statistics to distinguish breast cancer histopathology images. To further boost the classification performance, we also integrate asymmetric convolution into the second‐order network and propose a novel second‐order asymmetric convolution network (SoACNet). SoACNet adopts a series of asymmetric convolution blocks to replace each stand square‐kernel convolutional layer of the backbone architecture, followed by a global covariance pooling to compute second‐order statistics of deep features, leading to a more robust representation of histopathology images. Extensive experiments on the public BreakHis dataset demonstrate the effectiveness of SoACNet for breast cancer histopathology image classification, which achieves competitive performance with the state‐of‐the‐arts.