bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers to Self-Care Management among Type 2 diabetes Patients in Tigray, Ethiopia: A qualitative Study
Authors: Berhe Kalayou K. , Mselle Lilian T. , Gebru Prof. Haftu B. 
Published: July 2022

Abstract
Background
A diabetic patient is anticipated to follow recommended self-care management to manage diabetes properly. Adherence to self-care management is effective in the management of diabetic complications. The aim was to explore barriers to self-management among type 2 diabetes patients at Tigray, Ethiopia, 2020.
Method
The descriptive qualitative design was used to conduct a study between April and September 2020. Participants were selected purposively to recruit 22 patients with type 2 diabetes, 10 caretakers and health care providers. Data were analyzed thematically and Atlas ti software was used during analysis.
Results
The reported barriers were Lacking education to cope with the disease, being emotionally disturbed, Failing to adopt new life style, lacking social support, Perceived behavioral control and inadequacy of health care system.
Conclusion
Type 2 diabetes patients were unable to adhered self-care management due to educational, psychological, social, behavioral and health care system related barriers.
Parallel functional annotation of cancer-associated missense mutations in histone methyltransferases
Authors: Cosgrove Michael , Canning Ashley , Viggiano Susan , Fernandez-Zapico Martin 
Published: July 2022

Abstract
Using exome sequencing for biomarker discovery and precision medicine requires connecting nucleotide-level variation with functional changes in encoded proteins. However, for functionally annotating the thousands of cancer-associated missense mutations, or variants of uncertain significance (VUS), purifying variant proteins for biochemical and functional analysis is cost-prohibitive and inefficient. We describe parallel functional annotation (PFA) of large numbers of VUS using small cultures and crude extracts in 96-well plates. Using members of a histone methyltransferase family, we demonstrate high-throughput structural and functional annotation of cancer-associated mutations. By combining functional annotation of paralogs, we discovered two phylogenetic and clustering parameters that improve the accuracy of sequence-based functional predictions to over 90%. Our results demonstrate the value of PFA for defining oncogenic/tumor suppressor functions of histone methyltransferases as well as enhancing the accuracy of sequence-based algorithms in predicting the effects of cancer-associated mutations.
Influence of the Osteogenomic Profile in Response to Alendronate Therapy in Postmenopausal Women with Osteoporosis: A Retrospective Cohort Study
Authors: Arana Ismael Nuño , Vega Alejandra Villagómez , Nava Jorge Gámez , González Francisco Ruiz , Romero Misael Pérez , Rangel Walter Trujillo 
Published: July 2022

Abstract
Alendronate are used as the first line of pharmacological treatment for osteoporosis; however, some of them do not respond adequately to therapy with alendronate. The aim of this study was to investigate the influence of combinations of potential risk alleles (genetic profiles) associated with the response to antiosteoporotic treatment in a cohort consisting of 82 postmenopausal women with primary osteoporosis receiving alendronate (70 mg administered orally per week) for one year. Bone mineral density (BMD; g/cm2) of the femoral neck and lumbar spine was measured. According to BMD change patients were divided in two groups: responders and non-responders to alendronate therapy. Polymorphic variants in CYP19, ER, IL-6, PTHR1, TGFβ, OPG and RANKL genes were determined and profiles generating from the combination of risk alleles. Results: 56 subjects were responders to alendronate and 26 subjects were non-responders. The carriers of A-C-T-C profile (constructed from rs700518, rs1800795, rs2073618, and rs3102735) were predisposed to response to alendronate treatment (P= 0.001). Our findings highlight the importance of identified profiles for pharmacogenetics of alendronate therapy in osteoporosis.
Image Scene Layout Extraction Based on Random Walks Method Using Predefined Weighting Map
Authors: Khan Altaf , Chefranov Alexander , Demirel Hasan 
Published: July 2022

Abstract
3D layout extraction of a single image is an important aspect of artificial intelligence (AI) applications, e.g., 3D TV, object localization, and scene understanding. The pixel-level 3D layout of a single image can be extracted by using the prior information of image scene geometry. State-of-the-art Lou’s method introduces predefined templates corresponding to 3D scene geometry which use as prior information to extract the pixel-level 3D layout from a single image. 3D scene geometries called as Stages, are rough models of indoor and outdoor scenes. We introduce a new method of 3D layout extraction by using template-based segmentation as prior information and further template-based-segmentation is used as weighting map in random walk method to enhance the edges between two regions. Next, for each sub-region, multiple seeds are initialized by random walk method and their output segments are combined to generate 3D layout of a single image. Proposed algorithm is evaluated on the indoor and outdoor images dataset. The experimental results show that the proposed method has improved the accuracy by 5.31% versus the state-of-the-art methods. Additionally, this algorithm is extended for road scene extraction where instead of using template-based segmentation, the magnitude value of Gaussian derivative uses as weighting map. It is evaluated on KITTI road scene dataset and quantitatively compared to previous efforts on a publically available, provides superior results.
Modeling the effect of a temperature shock on the rotational motion of a small spacecraft, considering the possible loss of large elastic elements stability
Authors: Sedelnikov Andry , Serdakova Valeria , Orlov Denis , Nikolaeva Alexandra , Evtushenko Maxim 
Published: July 2022

Abstract
The paper investigates the issues of a small spacecraft large elastic elements temperature shock influence within the framework of a two-dimensional model of thermal conductivity, taking into account the possible loss of stability during the temperature shock. The loss of stability causes additional movements of large elastic elements sections. The thermoelasticity problem is solved, in which the parameters of the relative motion of large elastic elements, including the loss of stability, are estimated. Additional micro-accelerations resulting from the loss of stability are estimated. Recommendations are given to avoid the loss of stability during the temperature shock.
Weighted Entropic Associative Memory: A case study on Phonetic Representation and Learning
Authors: Pineda Luis A. , Morales Rafael 
Published: July 2022

Abstract
The Entropic Associative Memory (EAM) holds declarative but distributed representations of remembered objects. These are characterized as functions from features to discrete values in an abstract amodal space. Memory objects are registered or remembered through a declarative operation; memory recognition is defined as a logical test and cues of objects not contained in the memory are rejected directly without search; and memory retrieval is a constructive operation. In its original formulation, the content of basic memory units or cells was either on or off, hence all stored objects had the same weight or strength. In the present weighted version (W-EAM) we introduce a basic learning mechanism to the effect that the values of the cells used in the representation of an object are reinforced by the memory register operation. As memory cells are shared by different representations, the corresponding associations are reinforced too. The memory system supports a second form of learning: the distributed representation generalizes and renders a large set of potential or latent units that can used for recognizing novel inputs, which can in turn be used for improving the performance of both the deep neural networks used for modelling perception and action, and of the memory operations. This process can be performed recurrently in open-ended fashion and can be used in long term learning. An experiment in the phonetic domain using the Mexican Spanish DIMEx100 Corpus was carried out. This corpus was collected in a controlled noise-free environment, and was transcribed manually by human trained phoneticians, but consists of a relatively small number of utterances. DIMEx100 was used to produced the initial state of the perceptual and motor modules, and for testing the performance of the memory system at such state. Then the incremental learning cycle was modelled using the Spanish CIEMPIESS Corpus, consisting of a very large number of noisy untagged speech utterances collected from radio and TV. The results support the viability of the Weighted Entropic Associative Memory for modelling cognitive processes, such as phonetic representation and learning, for the construction of applications, such as speech recognition and synthesis, and as a computational model of natural memory.
Pediatric Adjusted Shock Index as a Predictor of Mortality by Sex Disparity in Pediatric Trauma: A Pan-Asian Trauma Outcome Study (PATOS)
Authors: Jung Eujene , Ro Young Sun , Ryu Hyun Ho , Shin Sang Do 
Published: July 2022

Abstract
Background
There are no reports of sex-specific, pediatric age-adjusted shock index (PASI) for pediatric trauma patients in previous studies. We aimed to determine the association between PASI and in-hospital mortality of pediatric trauma patients and whether this association differs depending on sex.
Methods
This is a prospective, multinational, and multicenter cohort study using the Pan-Asian Trauma Outcome Study (PATOS) registry in the Asia-Pacific region, conducted in pediatric patients who visited the participating hospitals. The main exposure of our study was abnormal (elevated) PASI measured in an emergency department (ED). The main outcome was in-hospital mortality. We performed a multivariable logistic regression analysis to estimate the association between abnormal PASI and study outcomes after adjusting for potential confounders. An interaction analysis between PASI and sex was also conducted.
Results
Of 6,280 pediatric trauma patients, 10.9% (686/6,280) of the patients had abnormal PASI. In multivariable logistic regression analysis, abnormal PASI was significantly associated with increased in-hospital mortality (aOR, 1.71; 95% confidence interval [CI], 1.16—2.53). Abnormal PASI had interaction effects with sex for in-hospital mortality (aOR, 1.86; 95% CI, 1.18—2.92 and aOR, 1.38; 95% CI, 0.64—2.95 for male and female, respectively) (p < 0.01).
Conclusions
Abnormal PASI is associated with increased in-hospital mortality in pediatric trauma patients. The prediction power of PASI for in-hospital mortality was maintained only in male patients. Further studies with sex- and age-specific shock index and age-specific are warranted.
The Design and Implementation of Campus informatization in Chinese Universities: A Conceptual Framework
Authors: Nong Liqiao , Liu Geping , Tang Changhui , Chen Ying 
Published: July 2022

Abstract
With the deepening of educational informatization and the integration of information technology into education, a new form of teaching and management has been emerged. Digital campus is one of the educational reform results, and it shall be established to support the development of intelligent education. This paper aims to explore an overall situation of implementing progress of campus informatization in Chinese universities, and design a conceptual framework of the digital campus, then find out the practical results of Chinese universities which applied the conceptual framework. The advanced technology applied in Chinese campus informatization was analyzed, the main characteristics of the digital campus were put forwarded, and a conceptual framework of digital campus in universities was designed. For this article, we've chosen the one-stop service platform of southwest university as a case study, the practical results of the digital campus include IC card services, integration services, one-stop services, wireless networks, and the implementation of the data center.
Highly Soluble Arylene Diimide Derivatives as Anolyte Materials with Two-Electron Storage for Ultrastable Neutral Aqueous Organic Redox Flow Batteries
Authors: Liu Xu , Zhang Xuri , Bao Chaoyu , Wang Zengrong , Li Guoping , Yan Ni , Li Mingjia , He Gang 
Published: July 2022

Abstract
Two-electron neutral aqueous organic redox flow batteries (AORFBs) hold more promising applications in the power grid than one-electron batteries because of their higher capacity. However, their development is strongly limited by the structural instability of the highly reduced species. By combining the extended π-conjugation structure of the anolytes and the enhanced aromaticity of the highly reduced species, we reported a series of highly water-soluble and inexpensive arylene diimide derivatives (NDI, PDI, TPDI) as novel two-electron storage anolyte materials for ultrastable AORFBs. Matched with (ferrocenylmethyl)trimethylammonium chloride (FcNCl) as catholyte, arylene diimide derivative-based AORFBs showed the highest stability in two-electron AORFBs to date. The NDI/FcNCl-based AORFB delivered 98.4% capacity retention at 40 mA cm− 2 for 350 cycles, and TPDI/FcNCl-based AORFB showed remarkable stability (1600 cycles) with 95.5% capacity retention at 20 mA cm− 2. This finding lays the theoretical foundation and offers a reference for improving the stability of two-electron AORFBs.
Moral Foundations, Values, and Reasoning in Extraordinary Altruists
Authors: Amormino Paige , Ploe Montana , Marsh Abigail 
Published: July 2022

Abstract
Donating a kidney to a stranger is a rare act of extraordinary altruism that appears to reflect a moral commitment to helping others. Yet little is known about patterns of moral cognition associated with extraordinary altruism. In this preregistered study, we compared the moral foundations, values, and patterns of utilitarian moral reasoning in altruistic kidney donors (n=61) and demographically matched controls (n=58). Altruists expressed more concern only about the moral foundation of harm, but no other moral foundations. Consistent with this, altruists endorsed utilitarian concerns related to impartial beneficence, but not instrumental harm. Contrary to our predictions, we did not find group differences between altruists and controls in global values. Extraordinary altruism generally reflected opposite patterns of moral cognition as those seen in individuals with psychopathy, a personality construct characterized by callousness and insensitivity to harm and suffering. Results link real-world, costly, impartial altruism primarily to moral cognitions related to alleviating harm and suffering in others rather than to global values, fairness concerns, or strict utilitarian reasoning.
Enhancement of pigment and proximate values of intergeneric hybrid of protoplast fusion of Monascus ruber and Pleurotus ostreatus
Authors: Kannan Suganya , Ayyakannu Usha Raja Nanthini 
Published: July 2022

Abstract
Protoplast fusion is a crucial technique for strain enhancement that brings genetic recombination to filamentous fungus and creates hybrid strains. In this present study, the intergenic fusion between M. ruber and P. ostreatus has been carried out to enhance pigments, secondary metabolites, and proximate values. Protoplasts from M. ruber and P. ostreatus were isolated and an equal amount of protoplast was taken and performed protoplast fusion. The regenerated colonies were plated in potato dextrose agar with selected biological markers (nystatin and fluconazole) for the confirmation of the hybrid. In a standardized condition, the protoplast yield of M. ruber and P. ostreatus was 2.31×107 cells/ml and 2.33×107 cells/ml, respectively. Acidic pH yielded high amounts of protoplasts than neutral and alkaline pH. KCl showed a high yield of protoplasts 2.36×106 cells /ml from M. ruber and 2.46×107cells/ml from P. ostreatus. The colony resistance to nystatin and fluconazole was confirmed that the obtained regenerated colonies were fusant. The fusant has no septation in its transverse walls with lipid droplets. Fusion of protoplast from M. ruber and P. ostreatus resulted in genetic inference at the metabolic levels, explaining the elevation of pigment in fusant colonies. The proximate composition of fusant strains was higher. In conclusion, we have developed a new strain with genetic variance capable of producing an increased level of pigment with nutritional value through protoplast fusion that allows the generation of fusant with the characteristics of parent strains and elucidates the effectiveness of fusant for commercial applications.
Springer Nature 2021 L A T E X template Monotone Ratio theorem convergence rate and its consequences in the theory of continuous-time Markov branching systems
Authors: Imomov Azam A. , Murtazaev Misliddin 
Published: July 2022

Abstract
We consider a critical homogeneous-continuous-time Markov branching system , i.e. the average value of the branching rate is one. Our basic assumption is that the branching rate generating function of the system regularly varies, in which slowly varying factor varies at infinity with an explicit expression remainder. We essentially rely on the improved version of the Basic Lemma of the critical Markov branching systems theory. First we establish a convergence rate in the Monotone ratio theorem. Subsequently we prove a local-convergence limit theorem on the asymptotic expansion of transition probabilities and their convergence to the invariant measure.MSC Classification: 60J80 , 60J85
Role of saline fluids in the growth of pyroxenes and garnet in metamorphosed banded iron formations and implications to crustal processes
Authors: Harlov Daniel E. , Windley B. F. , Satish-Kumar M. , Sajeev K. , Zhai M. 
Published: July 2022

Abstract
In this study we analysed layers of metamorphosed banded iron formation (BIF) in granulite-amphibolite facies tonalitic orthogneisses in the Kolli Massif of southern India with regard to their lithologies, whole rock chemistry, mineral reaction textures, and mineral chemistry and experimentally replicated the formation of pyroxene and garnet. On the basis of their mineral reaction textures along magnetite-quartz grain boundaries these BIF layers are grouped according to their predominant silicate mineralogy: 1) amphibole; 2) orthopyroxene; 3) orthopyroxene–clinopyroxene; 4) orthopyroxene-clinopyroxene-garnet; 5) clinopyroxene-garnet-plagioclase; and 6) silicate-absent. Two-pyroxene and garnet-pyroxene thermometry coupled with thermodynamic modelling of the magnetite-quartz-orthopyroxene-clinopyroxene-bearing lithologies indicates that the magnetite-quartz-orthopyroxene-clinopyroxene-garnet assemblages formed at ~ 10 kbar and 750 to 900°C under relatively low H2O activities. Magnetite-quartz-orthopyroxene textures were experimentally replicated at 800 and 900°C and 10 kbars using isolated magnetite grains in a quartz matrix to which was added small amounts of a hypersaline MgCl2- and Al2O3-bearing fluid, which permeated along all available grain boundaries. The fact that silicate reaction textures did not form in one of the BIF samples, which had experienced the same P-T, whereas a variety of orthopyroxene +/- clinopyroxene +/- garnet textures formed in the other BIF samples suggests that, unless the BIF was either initially contaminated during formation with or infiltrated from the surrounding rocks by Mg-, Al-, and Ca-bearing saline fluids, these silicate minerals could not and would not have formed from the inherent magnetite-quartz during granulite-facies metamorphism. These results indicate that saline fluids played a key role in progressing the metamorphic reactions during subduction of sediments.
Maize harvester gearbox design modification for improved fatigue life
Authors: Kim Ji-Tae , Lee Ho-Seop , Park Jung-Ho , Woo Jea-Keun , Choi Il-Su , Kim Young-Keun , Cho Seong-Je , Ha Chang-Sub , Park Young-Jun 
Published: July 2022

Abstract
A gearbox is a power transmission system consisting of various machine elements such as gears, bearings, shafts, and housings. The gearbox has the advantage of being able to change the torque and rotation speed according to the gear ratio and has high power transmission efficiency by transmitting power through the contact of the gear pair. Although improvement and optimization of gearbox performance was researched in various fields, it is being conducted using an equivalent load condition rather than an actual workload. If the gearbox is evaluated using the equivalent load condition, the evaluation results are less reliable. Therefore, the gearbox must be evaluated under the actual workload condition in which the gearbox is operated. In this study, the evaluation of the gearbox was performed based on the actual workload measured in the environment in which the gearbox operates, and design modifications were made to improve and optimize the gearbox performance. As a result, shaft deflection was reduced by rearrangement of the bearing, from an overhung type to a straddle type, thereby improving the fatigue life of the bearing. Finally, the load distribution acting on the gear tooth surface was improved through micro-geometry modification of the gear.
Racial and Ethnic variation in BRCA1 and BRCA2 genetic test results among individuals referred for genetic counseling at a large urban comprehensive cancer center
Authors: Abdallah Nadine , Purrington Kristen S. , Tatineni Sushma , Assad Hadeel , Petrucelli Nancie , Simon Michael S. 
Published: July 2022

Abstract
Purpose: The prevalence of pathogenic variants in BRCA1 and BRCA2 in populations other than Ashkenazi Jewish (AJ) is not well defined. We describe the racial and ethnic-specific prevalence of BRCA1/2 pathogenic variants and variants of uncertain significance (VUS) among individuals referred for genetic testing in a large urban comprehensive cancer center over a 20-year period. Methods: The population included 3,537 unrelated individuals who underwent genetic testing from January 1999 to October 2019 at the Karmanos Cancer Institute. We estimated the prevalence of pathogenic variants and VUS and evaluated associations with race and ethnicity for African American (AA), Arab, AJ and Hispanic individuals compared to Non-Hispanic Whites (NHW). We used multivariable models to adjust for other predictors of pathogenic variants. We also reported the most common pathogenic variants by racial and ethnic group. Results: The racial and ethnic breakdown of our population was: NHW (68.9%), AA (20.3%), AJ (2.5%), Arab (2.2%), Hispanic (1.0%), Asian Pacific Islander, Native American/Alaskan Native (4.7%), and <1% unknown. The overall prevalence of pathogenic variants in BRCA1/2 was 8.9% and the prevalence of VUS was 5.6%. Compared to NHW, there were no racial or ethnic differences in the rate of pathogenic variants. However, AA individuals were more likely to have VUS in BRCA1 (adjusted OR 2.43, 95% CI 1.38-4.28) and AJ more likely to have VUS in BRCA2 (adjusted OR 3.50, 95% CI 1.61-6.58).Conclusion: These results suggest the continued need for genetic testing and variant reclassification for individuals of all race and ethnic groups.