bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel targets in rectal cancer by considering lncRNA–miRNA–mRNA network in response to Lactobacillus acidophilus consumption: a randomized clinical trial
Authors: Khodaii Zohreh , Mehrabani Natanzi Mahboobeh , Khalighfard Solmaz , Ghandian Zanjan Maziar , Gharghi Maryam , Khori Vahid , Amiriani Taghi , Rahimkhani Monireh , Alizadeh Ali Mohammad 
Published: June 2022

AbstractWe aimed to explore the lncRNA–miR–mRNA network in response to Lactobacillusacidophilus (L. acidophilus) consumption in rectal cancer patients. The candidate miRs were first taken from the GEO and TCGA databases. We constructed the lncRNA–miR–mRNA network using the high-throughput sequencing data. At last, we created a heatmap based on the experimental data to show the possible correlation of the selected targets. The expression levels of selected targets were measured in the samples of 107 rectal cancer patients undergoing placebo and probiotic consumption and 10 noncancerous subjects using Real-Time PCR. Our analysis revealed a group of differentially expressed 12 miRs and 11 lncRNAs, and 12 genes in rectal cancer patients. A significant expression increase of the selected tumor suppressor miRs, lncRNAs, and genes and a substantial expression decrease of the selected oncomiRs, onco-lncRNAs, and oncogenes were obtained after the probiotic consumption compared to the placebo group. There is a strong correlation between some network components, including miR-133b and IGF1 gene, miR-548ac and MSH2 gene, and miR-21 and SMAD4 gene. In rectal cancer patients, L.acidophilus consumption was associated with improved expression of the lncRNA–miR–mRNA network, which may provide novel monitoring and therapeutic approaches.
Disparity in association of obesity measures with ankle and brachial systolic blood pressures in Europeans and South Asians
Authors: Berceanu Matei , Cheng Chew W. , Viswambharan Hema , Kain Kirti 
Published: June 2022

AbstractObesity causes increases in brachial systolic-blood-pressures (SBP), risks of type 2 diabetes (T2DM) and cardiovascular diseases (CVD). Brachial and ankle SBPs have differential relationship with T2DM and CVD. Our objective was to study the relationship of obesity measures with brachial and ankle SBPs. A population of 1098 adults (South Asians n = 699; 41.70% male and 58.3% female) were recruited over 5 years from primary care practices in England. Their four limbs SBPs were measured using Doppler machine and body-mass-index (BMI) and waist-to-height-ratio (WHtR) calculated. Linear regressions were performed between SBPs and obesity measures, after adjustments for sex, age, ethnicity, T2DM and CVD. The mean age of all participants was 51.3 (SD = 17.2), European was 57.7 (SD 17.2) and South Asian was 47.8 (SD = 16.1). The left posterior tibial [Beta = 1.179, P = 4.559 × 10−15] and the right posterior tibial SBP [Beta = 1.178, P = 1.114 × 10−13] most significantly associated with the BMI. In South Asians, although the left brachial [Beta = 25.775, P = 0.032] and right brachial SBP [Beta = 22.792, P = 0.045] were associated to the WHtR, the left posterior tibial SBP [Beta = 39.894, P = 0.023], association was the strongest. For the first time, we have demonstrated that ankle SBPs had significant association with generalised obesity than brachial systolic blood pressures (SBP), irrespective of ethnicity. However, with respect to visceral obesity, the association with ankle SBP was more significant in South Asians compared to Europeans.
Coronal loop kink oscillation periods derived from the information of density, magnetic field, and loop geometry
Authors: Chen G. Y. , Chen L. Y. , Guo Y. , Ding M. D. , Chen P. F. , Erdélyi R. 
Published: June 2022

Context. Coronal loop oscillations can be triggered by solar eruptions, for example, and are observed frequently by the Atmospheric Imaging Assembly (AIA) on board Solar Dynamics Observatory (SDO). The Helioseismic and Magnetic Imager (HMI) on board SDO offers us the opportunity to measure the photospheric vector magnetic field and carry out solar magneto-seismology (SMS).
Aims. By applying SMS, we aim to verify the consistency between the observed period and the one derived from the information of coronal density, magnetic field, and loop geometry, that is, the shape of the loop axis.
Methods. We analysed the data of three coronal loop oscillation events detected by SDO/AIA and SDO/HMI. First, we obtained oscillation parameters by fitting the observational data. Second, we used a differential emission measure (DEM) analysis to diagnose the temperature and density distribution along the coronal loop. Subsequently, we applied magnetic field extrapolation to reconstruct the three-dimensional magnetic field and then, finally, used the shooting method to compute the oscillation periods from the governing equation.
Results. The average magnetic field determined by magnetic field extrapolation is consistent with that derived by SMS. A new analytical solution is found under the assumption of exponential density profile and uniform magnetic field. The periods estimated by combining the coronal density and magnetic field distribution and the associated loop geometry are closest to the observed ones, and are more realistic than when the loop geometry is regarded as being semi-circular or having a linear shape.
Conclusions. The period of a coronal loop is sensitive to not only the density and magnetic field distribution but also the loop geometry.
Probing stellar cores from inversions of frequency separation ratios
Authors: Bétrisey J. , Buldgen G. 
Published: June 2022

Context. With the rapid development of asteroseismology thanks to space-based photometry missions such as CoRoT, Kepler, TESS, and in the future, PLATO, and the use of inversion techniques, quasi-model-independent constraints on the stellar properties can be extracted from a given stellar oscillation spectrum. In this context, inversions based on frequency separation ratios, which are less sensitive to surface effects, appear as a promising technique to constrain the properties of stellar convective cores.
Aims. We developed an inversion based on frequency separation ratios, with the goal of damping the surface effects of the oscillation frequencies. Using this new inversion, we defined a new indicator to constrain the boundary mixing properties of convective cores in solar-like oscillators.
Methods. We verified our inversion technique by conducting tests in a controlled environment, where the stellar mass and radius were known exactly, and conducted an extensive hare and hounds exercise.
Results. The inversion is not affected by surface effects. With the construction of an extensive set of models, favoured and forbidden regions can be highlighted in the parameter space. If the ratios are well fitted, unsurprisingly the inversion does not provide any additional information.
Conclusions. The indicator, coupled with the inversion based on frequency separation ratios, seems promising at probing the properties of convective cores, especially for F-type stars exhibiting solar-like oscillations.
Primär endoprothetische Versorgung von Kniegelenksfrakturen
Authors: Förch Stefan , Lisitano Leonard , Mayr Edgar 
Published: June 2022

ZusammenfassungWährend die primäre prothetische Versorgung von Schenkelhalsfrakturen ein etabliertes Verfahren und bei geriatrischen Patienten den Goldstandard darstellt, wird die primäre endoprothetische
Versorgung bei kniegelenknahen Frakturen deutlich seltener angewendet. Vor allem bei älteren Patienten findet sie Anwendung bei Frakturen mit vorbestehender symptomatischer Gonarthrose oder
Frakturen, die aufgrund ihrer Komplexität und vorbestehender reduzierter Knochenqualität nicht osteosynthetisch zu versorgen sind.Die operative Umsetzung ist komplex und bedarf entsprechender Erfahrung in der Primär- und vor allem auch Revisionsendoprothetik, einer Logistik mit Vorhaltung entsprechender Implantate und
einer guten präoperativen Planung.Auch wenn hochwertige Studien weitgehend fehlen, gibt es vor allem seit Anfang der 2000er-Jahre immer wieder Berichte und Fallserien zur primären endoprothetischen Versorgung
kniegelenknaher Frakturen. Kumulativ liegen Berichte von jeweils gut 200 Fällen nach distalen Femur- und proximalen Tibiafrakturen vor. Die Komplikationsraten werden zwischen 0 und 90%
angegeben und betreffen vor allem Wundheilungsstörungen und Infekte. Funktionell können überwiegend sehr gute bis zufriedenstellende Ergebnisse und Bewegungsumfänge von 100° erzielt
werden.Die primäre endoprothetische Frakturversorgung kniegelenknaher Frakturen sollte in ausgewählten Fällen als Therapieoption in Betracht gezogen werden. Es lassen sich mit hoher
Zuverlässigkeit gute funktionelle Ergebnisse erzielen, Hauptkomplikationen sind Wundheilungsstörungen und Infekte.
The Untapped Potential of Nursing and Allied Health Data for Improved Representation of Social Determinants of Health and Intersectionality in Artificial Intelligence Applications: A Rapid Review
Authors: Ronquillo Charlene Esteban , Mitchell James , Alhuwail Dari , Peltonen Laura-Maria , Topaz Maxim , Block Lorraine J. 
Published: June 2022

Objectives: The objective of this paper is to draw attention to the currently underused potential of clinical documentation by nursing and allied health professions to improve the representation of social determinants of health (SDoH) and intersectionality data in electronic health records (EHRs), towards the development of equitable artificial intelligence (AI) technologies.
Methods: A rapid review of the literature on the inclusion of nursing and allied health data and the nature of health equity information representation in the development and/or use of artificial intelligence approaches alongside expert perspectives from the International Medical Informatics Association (IMIA) Student and Emerging Professionals Working Group.
Results: Consideration of social determinants of health and intersectionality data are limited in both the medical AI and nursing and allied health AI literature. As a concept being newly discussed in the context of AI, the lack of discussion of intersectionality in the literature was unsurprising. However, the limited consideration of social determinants of health was surprising, given its relatively longstanding recognition and the importance of representation of the features of diverse populations as a key requirement for equitable AI.
Conclusions: Leveraging the rich contextual data collected by nursing and allied health professions has the potential to improve the capture and representation of social determinants of health and intersectionality. This will require addressing issues related to valuing AI goals (e.g., diagnostics versus supporting care delivery) and improved EHR infrastructure to facilitate documentation of data beyond medicine. Leveraging nursing and allied health data to support equitable AI development represents a current open question for further exploration and research.
Desiderata for a New Generation of EHRs for Inclusive Healthcare
Authors: Román-Villarán Esther , Ammenwerth Elske , Wijayaratne Jayathri , Parra-Calderón Carlos Luis 
Published: June 2022

Objectives: This research addresses several factors relevant to inequity in healthcare that may be susceptible to being addressed in a new generation of electronic health records (EHRs).
Methods: Through a scoping review of the literature, inequities related to ethnicity, gender, and socioeconomic aspects in healthcare in general and, more specifically in EHRs, have been considered. Papers have been identified between 2011 and 2022 in three categories: EHR, gender inequalities, and ethnicity inequalities.
Results: Twenty-two recommendations have been identified within the scope of the three categories indicated above. These exposed requirements focus on two spheres: (1) technical sphere, mainly focused on the characteristics and tools that the EHR should develop from taking into account the studied inequalities; and (2) clinical sphere, which mainly affects patients, health professionals, and health providers.
Conclusions: Ethnic and gender inequalities are essential factors to take into account when diagnosing, monitoring, preventing, and treating a patient. These factors give us the keys to discovering recommendations for a new generation of EHRs to help mitigate these needs.
Natural Language Processing: from Bedside to Everywhere
Authors: Aramaki Eiji , Wakamiya Shoko , Yada Shuntaro , Nakamura Yuta 
Published: June 2022

Objectives: Owing to the rapid progress of natural language processing (NLP), the role of NLP in the medical field has radically gained considerable attention from both NLP and medical informatics. Although numerous medical NLP papers are published annually, there is still a gap between basic NLP research and practical product development. This gap raises questions, such as what has medical NLP achieved in each medical field, and what is the burden for the practical use of NLP? This paper aims to clarify the above questions.
Methods: We explore the literature on potential NLP products/services applied to various medical/clinical/healthcare areas.
Results: This paper introduces clinical applications (bedside applications), in which we introduce the use of NLP for each clinical department, internal medicine, pre-surgery, post-surgery, oncology, radiology, pathology, psychiatry, rehabilitation, obstetrics, and gynecology. Also, we clarify technical problems to be addressed for encouraging bedside applications based on NLP.
Conclusions: These results contribute to discussions regarding potentially feasible NLP applications and highlight research gaps for future studies.
Resultados da abordagem de Carlson para o tratamento de fraturas no platô tibial posterior*
Authors: Alencar Neto Jonatas Brito de , Rego Itallo Epaminondas de Queiroz , Lopes Márcio Bezerra Gadelha , Lima Lana Lacerda de , Clazzer Renata , Ariel de Lima Diego 
Published: June 2022

Resumo
Objetivos O objetivo deste trabalho é descrever uma série de casos de fraturas de tíbia submetidas ao tratamento cirúrgico pela via posterior de Carlson para avaliação de resultados funcionais e frequência de complicações.
Métodos Onze pacientes com fraturas do platô tibial foram submetidos a tratamento cirúrgico pela via de Carlson de julho a dezembro de 2019 e acompanhados por um período mínimo de 6 meses. As pontuações American Knee Society Score (AKSS), American Knee Society Score/Function (AKSS/Função) e de Lysholm verificaram os resultados do tratamento 6 meses após a fratura. Os pacientes foram submetidos a radiografias comuns em incidência anteroposterior e de perfil para avaliação da consolidação da fratura e a cicatrização clínica foi determinada pela ausência de dor à descarga total de peso.
Resultados O período médio de acompanhamento foi de 12 meses (9 a 16 meses). O principal mecanismo de trauma foi acidente motociclístico e a fratura foi mais prevalente no lado direito. Oito pacientes eram do sexo masculino. A média de idade dos pacientes foi de 28 anos. Todas as fraturas cicatrizaram e nenhum paciente apresentou complicações. A AKSS foi excelente em 11 pacientes, com AKSS/Função média de 99,1 ± 3, e a mediana das pontuações de Lysholm foi de 95,0 ± 5,6.
Conclusões Nas fraturas posteriores do platô tibial, a abordagem de Carlson pode ser considerada segura, apresentando baixo índice de complicações e resultados funcionais satisfatórios.
Accurate virus identification with interpretable Raman signatures by machine learning
Authors: Ye Jiarong , Yeh Yin-Ting , Xue Yuan , Wang Ziyang , Zhang Na , Liu He , Zhang Kunyan , Ricker RyeAnne , Yu Zhuohang , Roder Allison , Perea Lopez Nestor , Organtini Lindsey , Greene Wallace , Hafenstein Susan , Lu Huaguang , Ghedin Elodie , Terrones Mauricio , Huang Shengxi , Huang Sharon Xiaolei 
Published: June 2022

Significance
A large Raman dataset collected on a variety of viruses enables the training of machine learning (ML) models capable of highly accurate and sensitive virus identification. The trained ML models can then be integrated with a portable device to provide real-time virus detection and identification capability. We validate this conceptual framework by presenting highly accurate virus type and subtype identification results using a convolutional neural network to classify Raman spectra of viruses. The accurate and interpretable ML model developed for Raman virus identification presents promising potential in a real-time, label-free virus detection system that could be used in future outbreaks and pandemics.
Gene-rich X chromosomes implicate intragenomic conflict in the evolution of bizarre genetic systems
Authors: Anderson Noelle , Jaron Kamil S. , Hodson Christina N. , Couger Matthew B. , Ševčík Jan , Weinstein Brooke , Pirro Stacy , Ross Laura , Roy Scott William 
Published: June 2022

SignificanceSex determination systems such as haplodiploidy, in which males' gene transmission is haploid, are surprisingly common, however, the evolutionary paths to these systems are poorly understood. X chromosomes may play a particularly important role, either by increasing survival of males with only maternal genomes, or due to conflicts between X-chromosomal and autosomal genes. We studied X-chromosome gene richness in three arthropod lineages in which males are diploid as adults but only transmit their maternally inherited haploid genome. We find that species with such atypical systems have far more X-chromosomal genes than related diploid species. These results suggest that conflict between genetic elements within the genome drives the evolution of unusual sex determination systems.
Structural and mechanistic basis of σ-dependent transcriptional pausing
Authors: Pukhrambam Chirangini , Molodtsov Vadim , Kooshkbaghi Mahdi , Tareen Ammar , Vu Hoa , Skalenko Kyle S. , Su Min , Yin Zhou , Winkelman Jared T. , Kinney Justin B. , Ebright Richard H. , Nickels Bryce E. 
Published: June 2022

SignificanceThe paradigmatic example of factor-dependent pausing in transcription elongation is σ-dependent pausing, in which sequence-specific σ-DNA interaction with a − 10 element-like sequence in a transcribed region results in pausing of a σ-containing transcription elongation complex. It has been proposed that σ-dependent pausing involves DNA scrunching, and that sequences downstream of the −10 element-like sequence modulate DNA scrunching. Here, using site-specific protein–DNA photocrosslinking, high-throughput sequencing, and cryoelectron microscopy structure determination, we show directly that σ-dependent pausing involves DNA scrunching, we define a consensus sequence for formation of a stable scrunched paused complex that is identical to the consensus sequence for pausing in initial transcription, and we identify positions of DNA scrunching on DNA nontemplate and template strands. Our results illuminate the structural and mechanistic basis of σ-dependent transcriptional pausing.
Citation in global academic knowledge making
Authors: Smirnova Natalia , Lillis Theresa 
Published: June 2022

AbstractThis paper introduces apaired text history methodologyto explore the citation practices of three experienced Russian scholars in philosophy, sociology, and economics. The empirical focus is on the analysis of three paired text histories, comparing Russian-medium research articles with English-medium research articles in each discipline. By analyzing the paired text histories through the use of multiple data sources – article drafts, email correspondence surrounding text production, and interviews – focusing specifically on the changes made to citations in each pair, the paper seeks to throw light on both micro and macro level knowledge production practices. At the micro level, the paper analyses changes made to citations across English and Russian-medium texts, documenting the involvement of literacy brokers, their evaluative requests about citations, and authors’ responses to such requests. At the macro level, the paper raises questions about what counts as ‘citeworthy’ in different geolinguistic contexts and considers the consequences of citation brokering and citation practices for knowledge production and circulation globally.
Academic texts in motion
Authors: Khuder Baraa , Petrić Bojana 
Published: June 2022

AbstractKnowledge production in collaborative writing for publication has tended to be studied as fixed in time and place; few studies have focused on the drafting and redrafting of texts and the interactions among the co-authors involved. Using atext historyapproach to a research article co-authored by an exiled academic and his two more experienced co-authors, all using English as an additional language, this study investigates the impact of interactions during text production on the focal academic’s understanding of writing for English-medium international publication. We analysed the co-authors’ comments on the academic’s drafts, examining theirIntervention Levels(levels of directness and explicitness) andIntervention Areas(disciplinary, writing, and publishing conventions) and the academic’s responses to these interventions. Analysis focused oninteraction episodes (written interactions relating to a specific point in the text and relevant textual changes throughout drafts). Findings revealed that interventions focused on multiple areas, with the co-authors acting as knowledge brokers in all domains. The interaction dynamics changed across the drafts, in the focus of interaction episodes and the levels of co-authors’ interventions provided to the academic, which created a space to negotiate interventions and, consequently, to enrich his understanding of writing practices for international publication in English.
Improved empirical formulas for α-decay half-lives of heavy and superheavy nuclei
Authors: Ismail M , Ellithi A Y , Adel A , Abbas M A 
Published: June 2022

Abstract
The empirical Royer formulas were readjusted with new set of coefficients using the latest experimental data and the recent evaluated

α

-decay half-lives over a wide range of 573 nuclei between 52

≤

Z

≤

118. The effects of the orbital angular momentum, isospin asymmetry, and parity have been examined in improving the adopted formulas. The modified formulas were tested for their accuracy by comparing with the recent experimental data and other theoretical calculations. The prediction of

α

-decay half-lives of several isotopes of the superheavy nuclei with

Z
=
120
−
126
,

which have not yet been experimentally synthesized, are presented and compared with other theoretical approaches. The behavior of

log

10

T

α

in relation to the neutron number variation is explored for about 40 isotopes of each element. Based on the minima found in

log

10

T

α

variation with neutron number, we found neutron stability at

N
=
184
,

190, 196, 200, 202, 204, 210, 216, 218, 220 and 228. The behavior of

log

10

T

α

with neutron variation for heavy and superheavy nuclei is almost the same as that found using more heavy and complicated calculations. The present method can be applied easily to study large number of nuclei.