bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of the enzymes required for the biosynthesis of 2,3‐diacetamido‐2,3‐dideoxy‐d‐glucuronic acid in Psychrobacter cryohalolentisK5T
Authors: Hofmeister Daniel L. , Seltzner Chase A. , Bockhaus Nicholas J. , Thoden James B. , Holden Hazel M. 
Published: November 2022

AbstractPsychrobacter cryohalolentis K5T is a Gram‐negative bacterium first isolated from Siberian permafrost in 2006. It has a complex O‐antigen containing l‐rhamnose, d‐galactose, two diacetamido‐sugars, and one triacetamido‐sugar. The biosynthetic pathway for one of the diacetamido‐sugars, namely 2,3‐diacetamido‐2,3‐dideoxy‐d‐glucuronic acid, is presently unknown. Utilizing the published genome sequence of P. cryohalolentis K5T, we hypothesized that the genes designated Pcryo_0613, Pcryo_0614, Pcryo_0616, and Pcryo_0615 encode for a uridine dinucleotide (UDP)‐N‐acetyl‐d‐glucosamine 6‐dehydrogenase, an nicotinamide adenine dinucleotide (oxidized) (NAD+)‐dependent dehydrogenase, a pyridoxal 5′‐phosphate (PLP)‐dependent aminotransferase, and an N‐acetyltransferase, respectively, activities of which would be required for the biosynthesis of this unusual carbohydrate. Here we present the cloning, overexpression, and purification of these hypothetical proteins. Kinetic data on the enzymes encoded by Pcryo_0613, Pcryo_0614, and Pcryo_0615 confirmed their postulated biochemical activities. In addition, the high‐resolution X‐ray structures of both the internal and external aldimine forms of the aminotransferase were determined to 1.25 and 1.0 Å, respectively. Finally, the three‐dimensional architecture of the N‐acetyltransferase in complex with its substrate and coenzyme A was solved to 1.8 Å resolution. Strikingly, the N‐acetyltransferase was shown to adopt a new motif for UDP‐sugar binding. The data presented herein provide additional insight into sugar biosynthesis in Gram‐negative bacteria.
Control efficacy and joint toxicity of metaflumizone mixed with chlorantraniliprole or indoxacarb against the fall armyworm, Spodoptera frugiperda
Authors: Wu Yu‐Jie , Wang Bing‐Jie , Wang Meng‐Ru , Peng Ying‐Chuan , Cao Hai‐Qun , Sheng Cheng‐Wang 
Published: November 2022

AbstractBACKGROUNDThe fall armyworm (FAW), Spodoptera frugiperda is the main destructive pest of grain crops, and has led to substantial economic losses worldwide. Chemical pesticides are the most effective way to manage FAW. Here, a laboratory test using an artificial diet‐incorporated assay was conducted to determine the toxicity of five insecticides and the joint effect of the binary combination insecticides to FAW larvae. A field plot test using foliar spray was carried out to assess the control efficacy of metaflumizone mixed with chlorantraniliprole or indoxacarb against FAW.RESULTSThe bioassay results showed that metaflumizone had a stronger insecticidal effect than indoxacarb toward FAW larvae. Furthermore, the mixture of metaflumizone and chlorantraniliprole in a volume ratio of 3:7 had the strongest synergistic effect against FAW, with a co‐toxicity coefficient (CTC) of 317.18. The best synergistic effect for mixtures of metaflumizone and indoxacarb was observed at a 1:9 volume ratio, with a CTC of 185.98. However, there was an antagonistic effect of metaflumizone mixed with emamectin benzoate and with lufenuron, because the co‐toxic factor was less than −20 at volume ratios of 8:2 and 9:1, respectively. According to the results of the field trial, metaflumizone mixed with chlorantraniliprole or indoxacarb at a 50% reduction of the application rate can effectively control FAW with efficacy ranging from 77.73% to 94.65% 1–7 days postapplication.CONCLUSIONOverall, our findings suggest that metaflumizone and its binary combination insecticides can be utilized in FAW integrated pest management programs. © 2022 Society of Chemical Industry.
Chiral β‐arylchalcogenium azide induce apoptosis and regulate Oxidative Damage on Human Bladder Cancer Cells
Authors: Lucia Ruiz Benitez Martha , Severo Sabedra Sousa Fernanda , Peter Furtado Izadora , Carlos Rodrigues Junior João , Victoria Mascarenhas Borba Msc. , Vieira Segatto Natália , Tabarelli Greice , Klein Couto Gabriela , Júlia Damé Fonseca Paschoal Msc. , Silveira Pacheco Bruna , E. D. Rodrigues Oscar , Collares Tiago , Kömmling Seixas Fabiana 
Published: November 2022

AbstractIn the present study, we aimed to evaluate the cytotoxic effect of chiral β‐Aryl‐chalcogenium azide compoundsin vitroagainst the human bladder cancer cell line 5637. The cell growth inhibition was evaluated by MTT assay. The apoptosis induction and cellular viability were measured by DAPI staining and live/dead assay, respectively. Also, gene expression of pro‐apoptotic, anti‐apoptotic and oxidative stress pathways were investigated by qRT‐PCR. Finally,in silicomolecular docking between the compounds and proteins involved in apoptotic and cell growth pathways was performed as well. Our results showed that 5c [(S)‐(2‐azido‐1‐phenyl‐3‐telurophenyl)‐propane)] and 5j [(S)‐(2‐azido‐1‐phenyl‐3‐teluro‐p‐methoxy‐phenyl)‐propane)] compounds presented concentration‐dependent cytotoxicity. Apoptosis analysis showed chromatin condensation in 13 % and 20.3 % of cells treated with compounds5 cand5 j, respectively, compared to untreated cells (2.34 %). Moreover,5 cincreased the relative expression ofp53,Caspase‐3,Caspase‐9,SODandCATgenes. Meanwhile,5 jincreased the expression ofp53,p21,Caspase‐3,Caspase‐9,Bax,SOD,CAT,GPx,GRandiNOSgenes. Finally, molecular docking showed that5 chas a binding affinity to Survivin, Bcl‐XL, RSK2, SGK1, while5 jshowed binding affinity to the SGK1 protein only. These findings suggest that β‐Aryl‐chalcogenium azide compounds could have a potential antitumoral effect in bladder cancer cellsin vitro.
Multifunctional Hollow MnO2@Porphyrin@Bromelain Nanoplatform for Enhanced Photodynamic Therapy
Authors: Zhu Xiaohui , Wang Min , Wang Haihui , Ding Yihang , Liu Yongfei , Fu Zhangcheng , Lin Danying , Lu Chunhua , Tu Xiankun 
Published: November 2022

AbstractPhotodynamic therapy (PDT) has been showing great potential in cancer treatment. However, the efficacy of PDT is always limited by the intrinsic hypoxic tumor microenvironment (TME) and the low accumulation efficiency of photosensitizers in tumors. To address the issue, a multifunctional hollow multilayer nanoplatform (H‐MnO2@TPyP@Bro) comprising manganese dioxide, porphyrin (TPyP) and bromelain (Bro), is developed for enhanced photodynamic therapy. MnO2 catalyzes the intracellular hydrogen peroxide (H2O2) to produce oxygen (O2), reversing the hypoxic TME in vivo. The generated O2 is converted into singlet oxygen (1O2) by the TPyP shell under near‐infrared light, which can inhibit tumor proliferation. Meanwhile, the Bro can digest collagen in the extracellular matrix around the tumor, and can promote the accumulation of H‐MnO2@TPyP@Bro in the deeper tumor tissue, further improving the therapeutic effect of PDT. In addition, MnO2 can react with the overexpressed glutathione in TME to release Mn2+. Consequently, Mn2+ not only induces chemo‐dynamic therapy based on Fenton reaction by converting H2O2 into hydroxyl radicals, but also activates the Mn2+‐based magnetic resonance imaging. Therefore, the developed H‐MnO2@TPyP@Bro nanoplatform can effectively modulate the unfavorable TME and overcome the limitations of conventional PDT for cancer diagnostic and therapeutic.
Ultrasensitive Self‐Driven Terahertz Photodetectors Based on Low‐Energy Type‐II Dirac Fermions and Related Van der Waals Heterojunctions
Authors: Zhang Kaixuan , Hu Zhen , Zhang Libo , Chen Yulu , Wang Dong , Jiang Mengjie , D'Olimpio Gianluca , Han Li , Yao Chenyu , Chen Zhiqingzi , Xing Huaizhong , Kuo Chia‐Nung , Lue Chin Shan , Vobornik Ivana , Wang Shao‐Wei , Politano Antonio , Hu Weida , Wang Lin , Chen Xiaoshuang , Lu Wei 
Published: November 2022

AbstractThe exotic electronic properties of topological semimetals (TSs) have opened new pathways for innovative photonic and optoelectronic devices, especially in the highly pursuit terahertz (THz) band. However, in most cases Dirac fermions lay far above or below the Fermi level, thus hindering their successful exploitation for the low‐energy photonics. Here, low‐energy type‐II Dirac fermions in kitkaite (NiTeSe) for ultrasensitive THz detection through metal‐topological semimetal‐metal heterostructures are exploited. Furthermore, a heterostructure combining two Dirac materials, namely, graphene and NiTeSe, is implemented for a novel photodetector exhibiting a responsivity as high as 1.22 A W−1, with a response time of 0.6 µs, a noise‐equivalent power of 18 pW Hz−0.5, with outstanding stability in the ambient conditions. This work brings to fruition of Dirac fermiology in THz technology, enabling self‐powered, low‐power, room‐temperature, and ultrafast THz detection.
Recent Advances on Heterojunction‐Type Anode Materials for Lithium‐/Sodium‐Ion Batteries
Authors: Fu Hao , Wen Qing , Li Pei‐Yao , Wang Zhen‐yu , He Zhen‐jiang , Yan Cheng , Mao Jing , Dai Kehua , Zhang Xia‐hui , Zheng Jun‐chao 
Published: November 2022

AbstractRechargeable batteries are key in the field of electrochemical energy storage, and the development of advanced electrode materials is essential to meet the increasing demand of electrochemical energy storage devices with higher density of energy and power. Anode materials are the key components of batteries. However, the anode materials still suffer from several challenges such as low rate capability and poor cycling stability, limiting the development of high‐energy and high‐power batteries. In recent years, heterojunctions have received increasing attention from researchers as an emerging material, because the constructed heterostructures can significantly improve the rate capability and cycling stability of the materials. Although many research progress has been made in this field, it still lacks review articles that summarize this field in detail. Herein, this review presents the recent research progress of heterojunction‐type anode materials, focusing on the application of various types of heterojunctions in lithium/sodium‐ion batteries. Finally, the heterojunctions introduced in this review are summarized, and their future development is anticipated.
A privacy oriented authorized key agreement framework for vehicular edge computing
Authors: Sharma Shanil , Mishra Dheerendra , Rana Saurabh 
Published: November 2022

AbstractThe revolution of technology has presented smart vehicles. To use reliable cloud service for smart vehicles at low latency, vehicular edge computing (VEC) is introduced. VEC adopts a unique approach for providing better vehicular connection, data storage, and sharing information among IoT‐enabled vehicles. However, the establishment of secure communication and authorized access to data in these cloud‐based services are always a concern. To ensure secure and authorized communication, we construct an authenticated key agreement framework for VEC. The edge computing‐based proposed vehicular communication protocol provides secure and authorized communication for an edge‐endorsed IoT environment. The security is proved on the random oracle model. The analysis of computational efficiency is also included. Furthermore, we have conferred the comparison analysis of our designed scheme with other schemes.
The on ramp: Essential entry level experience and skills in student affairs assessment
Authors: Aaron Robert W. , Cogswell Cynthia A. 
Published: November 2022

AbstractThis article explores the essential, and desired, skill set for working in the field of student affairs assessment. Required skills vary a great deal, and depend heavily upon the institutional culture for assessment, partnerships with administrators and faculty, and the size or scope of the student affairs division. The “on‐ramp” topic will be discussed in the following sections: overview of skills needed for any student affairs assessment department, specific skills useful in a small department (1‐2 FTE), specific skills useful in a medium‐to‐large department (3 FTE or more), and finally, conducting assessment with fewer than 1 FTE dedicated to the assessment role in student affairs.
Revision of EN 1993‐1‐1 – Design rules for structural analysis, cross‐sectional resistance and member buckling
Authors: Bureau Alain , Snijder (Bert) , Knobloch Markus , Kuhlmann Ulrike , Gardner Leroy , Taras Andreas , da Silva Luís Simões 
Published: November 2022

AbstractIn the framework of the revision of Eurocode 3, Part 1–1, several amendments have been proposed and accepted in order to improve the rules for the resistance to member buckling. For clarification, a flow chart connecting the global analysis (first or second order), the imperfections and the type of verification has been implemented for ease of use. Since the publication of the standard in 2005, many research projects have been conducted across Europe on this topic and their results have contributed to provide appropriate answers to problems identified in practice. Therefore, the revised code provides new design rules for stability. Important works of calibration have been performed in these different projects to derive appropriate values of the partial factor on the resistance side. For example, a new formulation for lateral–torsional buckling has been introduced for the calculation of the reduction factor. The consequence is a reduction of the discrepancy between the results obtained by these new methods and those from experimental or numerical tests. In order to extend the scope of Eurocode 3, Part 1–1, additional methods have been implemented in an annex to cover the stability of members with mono‐symmetric cross‐section under compression axial force, biaxial bending, with or without torsion. The format of the resistance criteria remains similar to the format of the current interaction formulae so that the designers can easily identify the evolution of the rules. This article presents in a systematic way the new implementations in the formal vote version FprEN 1993‐1‐1 of the code.
Co‐development of an integrated assessment framework to evaluate the effectiveness and impact of selected nature‐based water treatment technologies in Sri Lanka, The Philippines, and Vietnam
Authors: Jegatheesan Veeriah , Pachova Nevelina , Velasco Perlie , Mowjood Mohamed Ismail Mohammed , Weragoda Sujithra Kaushaliya , Makehelwala Madhubhashini , Trang Ngo Thuy Diem , Dang Bao‐Trong , Tran Cong‐Sac , Vo Thi‐Kim‐Quyen , Trang Nguyen Thi Thu , Pham Huy , Devanadera Ma. Catriona , Torrens Antonina , Bui Xuan‐Thanh , Nguyen Phuoc‐Dan , Lecciones Amy , Jinadasa Kristhombu Baduge Shameen Nishantha 
Published: November 2022

AbstractWater quality is a critical challenge in Asia in the context of growing industrialization, urbanization, and climate change. Nature‐based solutions (NbS) could play an important role in reducing urban water pollution, while generating multiple co‐benefits that could make cities more liveable and resilient. In this regard, a number of pilot and demonstration projects have been set up to explore their potential across cities in Asia. Their effectiveness and impacts, however, have not been adequately documented, thus how they can be sustained, replicated and up‐scaled remain poorly understood. This study aims to contribute to addressing this challenge by co‐developing an integrated assessment framework and employing it to understand how existing evaluations of NbS in the region can be improved. It focuses specifically on a set of nature‐based solutions that have been employed for water treatment across six cities in Southeast Asia (two in each Sri Lanka, the Philippines, and Vietnam), namely, floating wetlands, constructed wetlands and maturation ponds. The study also suggests specific methodologies for capturing a set of core indicators considered relevant for assessing the effectiveness and capturing the multi‐faceted impacts of the examined NbS.
Effect of salt solution treatment on impurity removal: A case study on phosphogypsum
Authors: Avşar Cemre , Ertunç Suna 
Published: November 2022

AbstractThis study gives a brief demonstration of impurity removal efficiency upon salt solution treatment of phosphogypsum (PG). The experimental set up has been designed according to a multi‐variable Box–Behnken Design (BBD) with stirring time, solid: liquid (PG:salt solution) ratio and temperature as the conducted in various salt solutions. PG sample has been treated with sea water, 5% NaCl and 10% NaCl solutions according to the BBD matrix. Fluoride (F), copper (Cu), manganese (Mn), and nickel (Ni) amounts in the PG sample have been measured upon pre‐ and post‐treatment with salt solutions. Among other operating conditions, temperature has been the dominant factor on fluoride removal efficiency, and responses for the factors determined in the experiment runs indicated that a significant correlation could be established between temperature and fluoride removal, sea water being the most efficient salt solution. Higher copper, manganese, and nickel removal efficiencies have been observed in single salt NaCl solution systems however no significant correlation could be established between factors. Results indicate that pre‐treatment of PG located near coastal regions with sea water can be a cost‐effective approach and applicable on industrial scale when fluoride removal is of importance.
Prioritizing Purposeful and Playful Language Learning in Pre‐K
Authors: Hadley Elizabeth Burke , Newman Katherine Mackay 
Published: November 2022

AbstractUsing play to meet specific learning goals in pre‐k can be challenging. In this article, we discuss why play is an essential activity for pre‐k learning. We share some research on the importance of supporting unconstrained, trifecta skills like oral language in the context of child‐centered, playful activities. We explain the importance of teacher scaffolding during play to meet specific language learning goals. Finally, we give practical strategies for planning and implementing play activities that will make a difference for children's language growth.
Engineering metal‐phenolic networks for enhancing cancer therapy by tumor microenvironment modulation
Authors: Xie Lisi , Li Jie , Wang Leyu , Dai Yunlu 
Published: November 2022

AbstractThe complicated tumor microenvironment (TME) is featured by low pH values, high redox status, and hypoxia, which greatly supports the genesis, development, and metastasis of tumors, leading to drug resistance and clinical failure. Moreover, a lot of immunosuppressive cells infiltrate in such TME, resulting in depressing immunotherapy. Therefore, the development of TME‐responsive nanoplatforms has shown great significance in enhancing cancer therapeutics. Metal‐phenolic networks (MPNs)‐based nanosystems, which self‐assemble via coordination of phenolic materials and metal ions, have emerged as excellent TME theranostic nanoplatforms. MPNs have unique properties including fast preparation, tunable morphologies, pH response, and biocompatibility. Besides, functionalization and surface modification can endow MPNs with specific functions for application requirements. Here, the representative engineering strategies of various polyphenols are first introduced, followed by the introduction of the engineering mechanisms of polyphenolic nanosystems, fabrication, and distinct properties of MPNs. Then, their advances in TME modulation are highlighted, such as antiangiogenesis, hypoxia relief, combination therapy sensitization, and immunosuppressive TME reversion. Finally, we will discuss the challenges and future perspectives of MPNs‐based nanosystems for enhancing cancer therapy.This article is categorized under:
Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
Featuring the Hall effect and variable thermal conductivity on magnetized hybrid nanoliquid flow for three distinct shapes of nanoparticles: A comparative study
Authors: Nandi Susmay , Kumbhakar Bidyasagar , Roy Nepal Chandra 
Published: November 2022

AbstractThe purpose of this work is to capture the circumstances of variable thermal conductivity and the Hall effect on the three‐dimensional rotating flow of hybrid nanofluid towards a bidirectional stretching sheet. The hybrid nanofluid is made by suspending nanometer‐sized copper (Cu) and alumina (Al2O3) nanoparticles in the base liquid water (H2O). The sheet is immersed in a Darcy porous medium. The flow is induced by both stretching of the sheet and thermal buoyancy force due to free convection. Further, nonlinear thermal radiation, frictional and Joule heating are prevalent in the temperature field. The surface boundary also imposes two constraints, namely velocity slip and convective heating. Another aspect of this analysis is to examine the impact of different shapes of copper and alumina nanoparticles on temperature distribution. For that, three variants, namely, spherical, blade, and lamina of nanoparticles shape, are considered. The resulting nonlinear differential equations are tackled by using Runge–Kutta–Fehlberg and secant methods‐based shooting technique. A detailed discussion on the physical impacts of various relevant parameters over velocity, temperature, local skin friction coefficients and Nusselt number is carried out with the help of graphs. Primary and secondary velocities of the hybrid nanofluid are accelerated for growing values of Hall current parameter, whereas the reverse trend is noticed w.r.t. velocity slip and suction parameters. Moreover, the hybrid nanofluid temperature profile has a direct relation with viscous dissipation and thermal radiation parameters. This research may have important applications in high‐ and low‐temperature operations, paints, space technologies, medications, cosmetics, conductive coatings, and so forth.
Haptics as an Interaction Modality
Authors: Hatzfeld Christian , Kern Thorsten A. 
Published: November 2022

AbstractThis chapter focuses on the biological and behavioural basics of the haptic modality. On the one side, several concepts for describing interaction are presented in Sect. 2.2, on the other side, the physiological and psychophysical basis of haptic perception is discussed in Sect. 2.1. The goal of this chapter is to provide a common basis to describe interactions and to convey a basic understanding of perception and the description by psychophysical parameters. Both aspects are relevant for the formal description of the purpose of a haptic system and the derivation of requirements, further explained in Chap. 5. Several conclusions arising from the description of perception and interaction are given in Sect. 2.4.
Shift symmetries for p-forms and mixed symmetry fields on (A)dS
Authors: Hinterbichler Kurt 
Published: November 2022

Abstract
Massive fields on (anti) de Sitter space realize extended shift symmetries at particular values of their masses. We find these symmetries for all bosonic p-forms and mixed symmetry fields, in arbitrary spacetime dimension. These shift symmetric fields correspond to the missing longitudinal modes of mixed symmetry partially massless fields where the top row of the Young tableau is activated.
PanScales parton showers for hadron collisions: formulation and fixed-order studies
Authors: van Beekveld Melissa , Ferrario Ravasio Silvia , Salam Gavin P. , Soto-Ontoso Alba , Soyez Gregory , Verheyen Rob 
Published: November 2022

Abstract
We formulate PanScales parton showers for hadron collisions so as to achieve next-to-leading logarithmic (NLL) accuracy across a broad set of observables. We do so specifically for colour singlet production. Relative to the existing PanScales final-state showers, the main new question is that of how to redistribute momentum imbalances from initial-state branching across the remainder of the event. We present tests of the showers at fixed order, including the treatment of full colour for soft-collinear emissions and of spin correlations in both the soft and collinear domains. We also include comparisons to a formulation of a standard dipole shower, the current leading-logarithmic state of the art. A forthcoming companion paper [1] will explore all-order tests of the new showers.