bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of the family‐based model of dialectical behavior therapy for both suicidal adolescents and young adults in an academic medical center
Authors: Darrow Sabrina M. , Maliken Ashley C. , Piatigorsky Auran , Stuart Barbara K. , Todd Natalie , Yaeger Alison M. , Londahl‐Shaller Esme A. 
Published: January 2022

AbstractBackgroundDialectical behavior therapy (DBT) is an effective approach to decreasing suicidal behaviors; the adapted, family‐based model for adolescents (through 18 years old; DBT‐A) also demonstrates efficacy. Data on higher dropout rates based on age, initial research on DBT with young adults in the community, and the theory that underlies DBT suggest that adaptations may also be appropriate for young adults. This study examines the effectiveness of DBT‐A, presents preliminary data on delivering DBT‐A to young adults (ages 18–26), and compares clinical characteristics, service utilization, and outcomes to adolescent clients (ages 13–17) to guide clinical considerations and future research on implementing DBT‐A.MethodsData were collected from a DBT‐A clinic and included results from semi‐structured diagnostic interviews, chart review, and scores on self‐report measures. The Suicide Ideation Questionnaire and Beck Depression Inventory (BDI), given at program entry, after completion of one rotation through the skills modules, and at graduation, were used to evaluate outcomes. Outcomes were benchmarked against prior DBT‐A trials. Adolescents' and young adults' clinical characteristics, service utilization, and outcomes were compared.ResultsThe effect size observed was smaller than in efficacy trials. Few differences were observed between teens (n = 87) and young adults (n = 45). Young adults were more likely to have participated in intensive services before DBT‐A. They participated in fewer family sessions and graduated in fewer months compared to teens.ConclusionThis study supports the use of the family‐based model of DBT for suicidal teens and young adults although future research is needed to improve the effectiveness of this model when implemented in real‐world settings.
A novel de novo frameshift variation in the SON gene causing severe global developmental delay and seizures in a Chinese female
Authors: Yi Zhi , Song Zhenfeng , Li Fei , Yang Chengqing , Xue Jiao , Li Lei , Zhang Mengxue , Zhang Ying 
Published: January 2022

AbstractBackgroundWith the rapid development of genetic detection technology, especially next‐generation sequencing, identification of the aetiology of unexplained intellectual disabilities accompanied by seizures and other dysmorphic features has become possible. The purpose of our paper is to make a definitive diagnosis of a girl with neonatal hypotonia, severe global developmental delay, seizures and mild facial dysmorphism.MethodsThe clinical data of the patient were retrospectively studied. Whole‐exome sequencing was performed on a blood sample from the patient. Subsequently, Sanger sequencing was utilized for validation of variants and parental validation.ResultsThe patient had hypotonia since the neonatal period. She showed a significant delay in physical and psychomotor development. She did not have any speech until the age of 2 years and 6 months. She had seizures that were easy to control with levetiracetam. The craniocerebral magnetic resonance imaging (MRI) then showed mild delayed myelination, enlarged bilateral ventricles and widened frontotemporal extracerebral space. Interictal video electroencephalogram (VEEG) was normal. She had esotropia and mild facial abnormalities with a flat nasal bridge and a short nose. She showed no abnormalities in the heart, genitourinary or skeletal systems. Whole‐exome sequencing revealed a novel de novo variant c.5334_5335delAG (p. Arg1778Serfs*11) in the SON gene.ConclusionOur paper reports a novel variant in the SON gene and provides a definitive diagnosis of a female with neonatal hypotonia, severe global developmental delay, seizures and mild facial abnormalities, which are symptoms consistent with Zhu–Tokita–Takenouchi–Kim syndrome (ZTTK syndrome).
Reflection types and students' viewing of feedback in a first‐year engineering course using standards‐based grading
Authors: Diefes‐Dux Heidi A. , Cruz Castro Laura M. 
Published: January 2022

AbstractBackgroundFeedback is one of the most powerful and essential tools for learning and assessment, particularly when it provides the information necessary to close an existing gap between actual and reference levels of performance. The literature on feedback has primarily focused on addressing strategies for providing effective feedback rather than aspects of students' readiness to engage with feedback.Purpose/HypothesisThis study investigated whether reflection, as a routine pedagogical intervention grounded in self‐regulated learning theory, promotes the frequency with which students view feedback.Design/MethodA quasi‐experimental design was employed to examine the relationship between the use of four different reflection types, as well as no reflection, and students' feedback viewing behaviors in a first‐year engineering course that used standards‐based grading. Clickstream data were gathered through the learning management system to count the number of times students viewed feedback. The number of feedback views was compared by reflection type using descriptive statistics and a generalized linear model; weekly feedback viewing patterns were examined using time‐descriptive graphs and the time‐series cluster analysis.ResultsFindings suggest reflection has the potential to increase the frequency of feedback views. Reflection not only had a positive and significant effect on the number of times students viewed feedback but also resulted in less variability between course sections and instructors when structured reflections made explicit references to feedback.ConclusionsStudents need feedback to learn effectively, but many do not view feedback without formal prompting. The authors recommend instructors consistently administer reflections that include explicit pointers to feedback throughout the semester.
Fullerene‐C60/NH2: A recyclable heterogeneous catalyst for the green synthesis of chromene and pyrimidine derivatives and antibacterial evaluation
Authors: Mirza‐Aghayan Maryam , Mohammadi Marzieh , Boukherroub Rabah 
Published: January 2022

AbstractAn effective procedure for the synthesis of amino‐functionalized fullerene with diethylenetriamine (C60‐NH2) is described. The obtained material was characterized by Fourier‐transform infrared spectroscopy, X‐ray diffraction, scanning electron microscopy, energy dispersive X‐ray spectroscopy, elemental analysis, thermogravimetric measurements, and X‐ray photoelectron spectroscopy. The catalytic activity of C60‐NH2 was studied in multicomponent reactions for the synthesis of chromene and pyrimidine derivatives. The results revealed that C60‐NH2 was very effective and the desired chromene and pyrimidine products were isolated in good to excellent yields 78%–97% and 81%–98%, respectively. Moreover, the C60‐NH2 catalyst could be recycled and reused for at least eight runs without substantial loss in its activity, which makes our procedure environmentally benign. Antibacterial behavior of some of the synthesized products was studied against Gram‐positive and Gram‐negative bacteria using disk and well diffusion methods. The chromene 4g showed a good antibacterial activity against both bacterial strains Staphylococcus aureus and Serratia marcescens. A good antibacterial activity was also detected for chromene 4o and pyrimidine 7j against S. aureus. The chromene 4m, 4n and pyrimidine 7i compounds displayed a good activity against Micrococcus luteus as a Gram‐positive bacterium.
The first evidence of hepatitis A virus subgenotype IIIA in the Eastern Brazilian Amazon, 1982–1983
Authors: Moreira Luiz V. L. , Malheiros Andreza P. , Barbosa Kemere M. V. , Freitas Pedro E. B. , Silva Andrea L. , Cruz Ana C. R. , Nunes Heloisa M. , das Chagas André A. C. , de Souza Alex J. S. 
Published: January 2022

AbstractHepatitis A virus (HAV) is a major causative agent of acute hepatitis worldwide. Although discovered in 1973, due to limitations of applicable serological and/or molecular methods, HAV remained under limited diagnosis until the late 1980s. This study aimed to retrospectively evaluate the serological and molecular prevalence of the HAV infection among 421 (n = 421) patients with a clinical and laboratory suspicion of acute hepatitis who were admitted in a reference laboratory in the Brazilian Eastern Amazon during 1982 and 1983. The 421 serum samples were screened for anti‐HAV IgM antibodies by enzymatic immunoassays. Positive samples were submitted to total RNA purification and tested by Nested reverse‐transcription polymerase chain reaction to amplify the HAV‐RNA VP1‐2A (522 bp) region. Anti‐HAV IgM antibodies were detected in 66% (278/421) of the patients. The highest prevalence was observed among males (57.9%, 161/278), and most often among children under 10 years old (63.3%, 176/278). HAV‐RNA was detected in 74.4% (207/278) of anti‐HAV IgM positive samples. HAV genotyping was performed in 71 samples, and 69 were classified into subgenotype IA. Two samples belonged to the HAV subgenotype IIIA. In this sense, retrospective studies can help in understanding the evolution and determination of wild genotypes and subtypes of HAV.
Opioid prescribing practices for pediatric tonsillectomy before and after policy interventions
Authors: Gerges Daniel , Wershoven Nicole , Hubbell Richard , Herrington Heather 
Published: January 2022

AbstractObjectiveThis study's purpose was to investigate opioid prescribing practices after pediatric tonsillectomy in the year before and year after implementation of statewide policy interventions in Vermont.MethodsWe reviewed charts of consecutive patients less than 18 years old that underwent tonsillectomy or adenotonsillectomy at a single tertiary academic medical center 1 year before (July 2016–June 2017) and 1 year after (July 2017–June 2018) implementation of policy interventions targeted at opioid prescribing. Data collected included demographics, procedure performed, indication, complications, medical comorbidities, opioid prescribing practices (medication, dose, morphine milliequivalents, and postdischarge opioid prescriptions), and postoperative telephone calls and emergency department (ED) visits.ResultsTonsillectomy or adenotonsillectomy was performed in 360 consecutive patients (185 in the pre‐policy year and 175 in the post‐policy year). Those receiving an opioid prescription in the pre‐ compared to post‐policy year was 49.7% versus 15.4% (p < .001). Of patients 6 years and older, 95.8% in the pre‐policy year compared to 25.2% in the post‐policy year received a postoperative opioid (p < .001). There was no difference in pain‐related office phone calls, postdischarge opioid prescriptions or ED visits between the two groups. There was no difference in morphine milligram equivalent prescribed in the pre‐ and post‐groups.ConclusionImplementation of statewide policy interventions can have a substantial impact on opioid prescribing practices in the pediatric tonsillectomy population without an increase in office phone calls, postdischarge opioid prescriptions, and ED visits.Level of Evidence4
Biodegradation and Immunological Parameters of Polyurethane‐Based Tissue Adhesive in Arterial Microvascular Anastomoses—A Long‐Term In Vivo Study
Authors: Modabber Ali , Winnand Philipp , Goloborodko Evgeny , Möhlhenrich Stephan Christian , Kniha Kristian , Tolba René , Jockenhoevel Stefan , Hermanns‐Sachweh Benita , Hölzle Frank , Heitzer Marius 
Published: January 2022

AbstractIn microsurgical anastomosis, non‐synthetic fibrin‐based adhesives have predominantly shown superior properties to synthetic cyanoacrylates, but they have hardly any clinical application. This study aims to investigate the local and systemic effects of synthetically produced biodegradable adhesive VIVO when used in microsurgical anastomosis. VIVO is used in two different anastomosis procedures in the common carotid artery in a rat model: VIVO in addition to a temporary catheter (VIVO TC) and VIVO with a custom‐shaped memory nitinol stent (VIVO SM). Conventionally sutured anastomoses serve as controls (C). Tissue response is assessed by in vivo fluorescence imaging and histological examination. The systemic effects of biodegradation are measured using hematologic parameters and serum levels of transaminase activity and lactate dehydrogenase. Finally, the degree of local adhesion of the different anastomotic procedures is evaluated. Fluorescence imaging shows reduced inflammatory blood flow in the VIVO TC group. Histological analysis of the anastomosed vessels also reveals significantly more inflammation in C than in the two adhesive groups. The severity of VIVO adhesions proves acceptable, and no histotoxic effects of VIVO are detected. The data demonstrate that the synthetic tissue adhesive VIVO is a reliable and—compared to sutures—tissue‐friendly adhesive for microsurgical anastomoses.
The Subtle Structure Modulation of A2‐A1‐D‐A1‐A2 Type Nonfullerene Acceptors Extends the Photoelectric Response for High‐Voltage Organic Photovoltaic Cells
Authors: Dai Tingting , Tang Ailing , Wang Jiacheng , He Zehua , Li Xianda , Guo Qing , Chen Xingguo , Ding Liming , Zhou Erjun 
Published: January 2022

AbstractMolecular structural modifications are utilized to improve the short‐circuit current (JSC) of high‐voltage organic photovoltaics (OPVs). Herein, the classic non‐fullerene acceptor (NFA), BTA3, is chosen as a benchmark, with BTA3b containing the linear alkyl chains on the middle core and JC14 fusing thiophene on the benzotriazole (BTA) unit as a contrast. The photovoltaic devices based on J52‐F: BTA3b and J52‐F: JC14 achieve wider external quantum efficiency responses with band edges of 730 and 800 nm, respectively than that of the device based on J52‐F: BTA3 (715 nm). The corresponding JSC increases to 14.08 and 15.78 mA cm−2, respectively, compared to BTA3 (11.56 mA cm−2). The smaller Urbach energy and higher electroluminescence efficiency guarantee J52‐F: JC14 a decreased energy loss (0.528 eV) and a high open‐circuit voltage (VOC) of 1.07 V. Finally, J52‐F: JC14 combination achieves an increased power conversion efficiency (PCE) of 10.33% than that of J52‐F: BTA3b (PCE = 9.81%) and J52‐F: BTA3 (PCE = 9.04%). Overall, the research results indicate that subtle structure modification of NFAs, especially introducing fused rings, is a simple and effective strategy to extend the photoelectric response, boosting the JSC and ensuring a high VOC beyond 1.0 V.
Size Regulation of Polydopamine Nanoparticles by Boronic Acid and Lewis Base
Authors: Huang Chuhao , Wang Xianheng , Yang Peng , Shi Shun , Duan Gaigai , Liu Xianhu , Li Yiwen 
Published: January 2022

AbstractSize regulation of polydopamine nanoparticles (PDA NPs) is vital to melanin‐inspired materials. The general strategy usually focuses on tuning of the reaction parameters which could affect the dopamine (DA) monomer polymerization process, such as pH, temperature, monomer concentration, etc. The reaction between boronic acids and catechols to form boronic esters has been widely applied in many fields, but little attention has been paid in the size regulation of PDA NPs. Here, it is speculated that the fine size regulation of PDA NPs can be directly achieved by using boronic acids and Lewis base molecules. It is found that these issues could indeed significantly affect the stability of the boronic esters formed by boronic acids and DA, which may further inhibit the monomer polymerization kinetics and tune the particle size of the resulting PDA NPs. It is also found that the several intrinsic properties of PDA NPs such as the free radical scavenging ability, UV spectral absorption, photothermal behavior, and structural color all change with the particle size. It is believed that this work can provide new opportunities for fabricating melanin‐inspired PDA NPs with well controlled size and properties.
Attention control in a trial of an online psychoeducational intervention for caregivers
Authors: Kovaleva Mariya , Nocera Joe R. , Hepburn Kenneth , Higgins Melinda , Nash Rachel , Epps Fayron , Brewster Glenna , Bilsborough Elizabeth , Blumling Amy A. , Griffiths Patricia C. 
Published: January 2022

AbstractIn reports of randomized controlled trials, thorough description of the attention control condition has been recommended, yet is frequently lacking. The Tele‐Savvy Caregiver program for informal caregivers of persons living with dementia was tested in a randomized controlled trial with an attention control condition. The purpose of this trial was to test Tele‐Savvy's efficacy in reducing the negative effects of caregiving on caregivers, promoting quality of life for persons living with dementia, and improving caregiver mastery. We describe the design and implementation of and examine the outcomes associated with the attention control condition. Caregivers were randomized to the immediate Tele‐Savvy (active condition), Healthy Living (attention control), or waitlist. The attention control content was focused on healthy lifestyle and was not intended to affect the outcomes that Tele‐Savvy targeted. The attention control group was similar to Tele‐Savvy in the intervention structure and duration: it consisted of seven weekly group videoconferences and 36 video lessons. Data on outcomes of caregivers and persons living with dementia were collected at baseline and 3 and 6 months postbaseline. Multilevel mixed effects models were used to determine changes in the outcomes. One hundred and eleven caregivers were randomized to the attention control condition (attrition 21.6%). Eighteen formative assessment interviews focusing on caregivers' experience in the attention control condition were conducted. The attention control condition completers had no statistically significant changes in the variables that Tele‐Savvy targeted. These results may be used in the design and implementation of attention control conditions in behavioral intervention research.
Biodegradation of water‐soluble and water‐dispersible polymers for agricultural, consumer, and industrial applications—Challenges and opportunities for sustainable materials solutions
Authors: Vandermeulen Guido W. M. , Boarino Alice , Klok Harm‐Anton 
Published: January 2022

AbstractThe development of more sustainable material solutions is one of the key challenges today. New materials are subject to an overall risk assessment of which their impact on the environment is an important aspect. The biodegradability of a material may support a positive risk assessment. Water‐soluble and water‐dispersible polymers are widely used in daily life in a very broad range of applications. In anticipation of a further tightening of regulatory requirements and as a consequence of the introduction of sustainability targets in industry, in the next decade or so, industry targets to replace the currently used and predominantly non‐biodegradable high value water‐soluble and water‐dispersible polymers by biodegradable alternatives, wherever sustainably possible. This review provides an overview of the currently used water‐soluble and water‐dispersible polymers in detergent formulations for home care, in water treatment and in crop protection. These polymers have been engineered to near perfect performance at minimum costs. We address the challenges faced when introducing biodegradable alternatives in existing product value chains, and we highlight opportunities to further improve and fine‐tune the biodegradation of these materials. This overview is intended to contribute to the development of novel biodegradable water‐soluble and water‐dispersible polymers, both at academia and industry.
Spacial structures induced by sterical hindrance of large substituents: A dendritic macromolecular “snowflake” molecule
Authors: Leitner Tanja D. , Mena‐Osteritz Elena , Bäuerle Peter 
Published: January 2022

AbstractThe mulitstage preparation of densly packed thienylene‐phenylene dendrimer 15 comprising 42 thiophene and 7 benzene units arranged in a hexagonal “snowflake” fashion is described. The desired three‐dimensionality is induced through steric repulsion of the peripheral hexa(thienyl)benzene units. The molecular geometry of individual dendrimers was supported by quantum chemical calculations, whereby atomic force microscopy gave evidence for spontaneous ordering of the molecules on a graphite surface by the formation of stable nanosized edge‐on oriented columns.
Destruxin A inhibits scavenger receptor B mediated melanization in Aphis citricola
Authors: Han Pengfei , Gong Qitian , Fan Jiqiao , Abbas Mureed , Chen Duo , Zhang Jianzhen 
Published: January 2022

AbstractBACKGROUNDDestruxin A (DA) is a mycotoxin secreted by entomogenous fungi, such as Metarhizium anisopliae, which has broad‐spectrum insecticidal activity. Insect innate immunity provides resistance against the invasion of entomopathogenic fungi. Previous studies have shown that DA could inhibit the immune response, however, the suppressive mechanism of DA on prophenoloxidase system is still unknown.RESULTSBased on the transcriptome of Aphis citricola, we screened the scavenger receptor class B(AcSR‐B)and identified that it significantly responds to DA. Spatio‐temporal expression analysis showed that AcSR‐B is highly expressed in adult stage and is mainly distributed in the abdominal region. We further revealed that both M. anisopliae and Escherichia coli could suppress the expression of AcSR‐B at 24 h, and that the expressed recombinant protein rAcSR‐B possessed agglutination activity to M. anisopliae and E. coli. DA could suppress the protein expression of AcSR‐B. In addition, RNA interference of AcSR‐B caused death of A. citricola in a dose‐dependent manner, and RNA interference of AcSR‐B increased mortality in A. citricola under the same lethal concentration of DA. The inhibiting effect of AcSR‐B silencing was similar with the DA treatment upon phenol oxidase (PO) activity of A. citricola hemolymph. DA could not decrease PO activity further after AcSR‐B silencing.CONCLUSIONDestruxin A inhibits melanization by suppressing AcSR‐B in A. citricola. Our findings are helpful in understanding the underlying molecular mechanism of the DA suppressing immune system, and uncover a potential molecular target for double‐stranded RNA (dsRNA) insecticides.
Curcumin suppress inflammatory response in traumatic brain injury via p38/MAPK signaling pathway
Authors: Li Guoqiang , Duan Lei , Yang Fengbiao , Yang Liang , Deng Yajun , Yu Yue , Xu Yanlong , Zhang Yinian 
Published: January 2022

AbstractTraumatic brain injury (TBI) is a common disease worldwide with a high mortality and disability rate and is closely related to the inflammatory response. However, the molecular mechanisms during the pathophysiological responses are not completely understood. This study was conducted to investigate the protective effect of curcumin on TBI and the molecular mechanisms of the p38/MAPK signal pathway. We found that curcumin remarkably ameliorated secondary brain injury after TBI, including effects on the neurological severity score and inflammation. After injection of curcumin, the neurological function score of mice decreased significantly. Curcumin exhibited antiinflammatory pharmacological effects, as reflected by inhibition of inflammatory factors (e.g., interleukin [IL]‐1β, IL‐6, and tumor necrosis factor [TNF]‐α). Additionally, curcumin notably reduced the expression of p‐p38 according to western blotting and immunohistochemical analyses. In conclusion, curcumin remarkably alleviated posttraumatic inflammation and thus shows potential for treating inflammation associated with TBI.