bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surveillance Imaging vs Symptomatic Recurrence Detection and Survival in Stage II-III Breast Cancer (AFT-01)
Authors: Schumacher Jessica R , Neuman Heather B , Yu Menggang , Vanness David J , Si Yajuan , Burnside Elizabeth S , Ruddy Kathryn J , Partridge Ann H , Schrag Deborah , Edge Stephen B , Zhang Ying , Jacobs Elizabeth A , Havlena Jeffrey , Francescatti Amanda B , Winchester David P , McKellar Daniel P , Spears Patricia A , Kozower Benjamin D , Chang George J , Greenberg Caprice C ,   for the Alliance ACS-CRP CCDR Breast Cancer Surveillance Working Group, Ballman Karla , Gavin Patrick , Green Bettye , Perlmutter Jane , Berger Elizabeth , Punglia Rinaa , Chen Ronald , Brys Nicole , Adesoye Taiwo 
Published: August 2022

Abstract

Background
Guidelines for follow-up after locoregional breast cancer treatment recommend imaging for distant metastases only in the presence of patient signs and/or symptoms. However, guidelines have not been updated to reflect advances in imaging, systemic therapy, or the understanding of biological subtype. We assessed the association between mode of distant recurrence detection and survival.

Methods
In this observational study, a stage-stratified random sample of women with stage II-III breast cancer in 2006-2007 and followed through 2016 was selected, including up to 10 women from each of 1217 Commission on Cancer facilities (n = 10 076). The explanatory variable was mode of recurrence detection (asymptomatic imaging vs signs and/or symptoms). The outcome was time from initial cancer diagnosis to death. Registrars abstracted scan type, intent (cancer-related vs not, asymptomatic surveillance vs not), and recurrence. Data were merged with each patient’s National Cancer Database record.

Results
Surveillance imaging detected 23.3% (284 of 1220) of distant recurrences (76.7%, 936 of 1220 by signs and/or symptoms). Based on propensity-weighted multivariable Cox proportional hazards models, patients with asymptomatic imaging compared with sign and/or symptom detected recurrences had a lower risk of death if estrogen receptor (ER) and progesterone receptor (PR) negative, HER2 negative (triple negative; hazard ratio [HR] = 0.73, 95% confidence interval [CI] = 0.54 to 0.99), or HER2 positive (HR = 0.51, 95% CI = 0.33 to 0.80). No association was observed for ER- or PR-positive, HER2-negative (HR = 1.14, 95% CI = 0.91 to 1.44) cancers.

Conclusions
Recurrence detection by asymptomatic imaging compared with signs and/or symptoms was associated with lower risk of death for triple-negative and HER2-positive, but not ER- or PR-positive, HER2-negative cancers. A randomized trial is warranted to evaluate imaging surveillance for metastases results in these subgroups.
Typical ephemeral plant—Erodium oxyrhinchum: growth response to snow change in temperate desert, Northwest China
Authors: Yin Jin-Fei , Zhou Xiao-Bing , Wu Nan , Zhang Yuanming 
Published: August 2022

AbstractSnow-cover changes in temperate desert ecosystems influence plant diversity, richness and distribution. The growth and distribution of herbaceous plants in these ecosystems are closely related to snow-cover depth, the most important water resource during the growth period due to water shortage during the dry season. However, the response to snow-cover change in winter remains unclear. The present investigation was undertaken to examine the influence of snow-cover change on the root growth of herbaceous species. The growth of desert typical ephemeral species, Erodium oxyrhinchum, was examined in Gurbantunggut Desert with four snow-cover depth treatments in winter. The four treatments were snow removal (−S), ambient snow, double snow (+S) and triple snow (+2S). The snow depth addition increased the abundance and growth rate of herbaceous plants. It also enhanced the biomass (including total and individual biomass) of these plants. The leaf area of E. oxyrhinchum increased significantly with snow addition, and the leaf dry matter content had an opposite trend. The study showed that the aboveground section of the plant was more sensitive to snow change than the underground. Snow change also influenced the root morphology. Snow removal resulted in the emergence of more lateral roots, whereas snow addition promoted the elongation of the main root for water and nutrient absorption. These results explain how changes in winter snow-cover depth alter plant growth, community structure and ecosystem function during the growing period in temperate desert ecosystems.
Surgical treatment of hepatic xanthogranuloma arising from a giant hepatic cyst causing gastrointestinal obstruction: a case report
Authors: Kohata Akihiro , Inoue Masashi , Nomimura Ken , Matsubara Kazuki , Kochi Masatoshi , Hotta Ryuichi , Miyamoto Kazuaki , Toyota Kazuhiro , Sadamoto Seiji , Takahashi Tadateru 
Published: August 2022

Abstract
Hepatic cysts are benign liver lesions and are often asymptomatic. Large hepatic cysts may cause jaundice and portal hypertension; however, they rarely cause gastrointestinal obstruction. Symptomatic cysts require treatment, and when malignancy is suspected, cyst puncture for pathological examination of the fluid may pose a risk of dissemination. Herein, we describe a case of xanthogranuloma arising from a large hepatic cyst that was causing duodenal obstruction. Thus, cyst puncture was performed for emergency decompression. Cytological examination of the puncture fluid revealed no malignant findings. Hence, laparoscopic deroofing was performed to treat the hepatic cyst. As the cyst and duodenal wall were firmly adherent, the cyst wall was left behind without dissection from the duodenum. A two-stage approach of cyst puncture followed by surgery may be an option for patients requiring urgent treatment for potentially malignant hepatic cysts.
Incidental discovery of goblet cell carcinoid, a rare appendiceal malignancy case report
Authors: Barbash Daniel , Trivedi Aakash A , Yang James Y , Nguyen Richard B , Huribal John C , Zuberi Jamshed , Elsawy Osama , Wessner Scott 
Published: August 2022

Abstract
Goblet cell carcinoid (GCC) tumor is a rare appendiceal carcinoma that has had several names throughout its history. Often found incidentally on pathology following an appendectomy, treatment includes a right hemicolectomy and possible adjuvant chemotherapy. Survival rate has been shown to be correlated with the histological features. Here, we report a 45-year-old African American male who presented with signs and symptoms consistent with acute appendicitis, but was ultimately diagnosed with GCC. After undergoing a right hemicolectomy, he continues to undergo long-term surveillance with his oncologist. Due to the rarity of this tumor, we describe the history of GCC and our recommendations for surgical and long-term management.
Subaltern subjectivity and embodiment in human rights practices
Authors: Abdelkarim Shaimaa 
Published: August 2022

Abstract
This article problematises the representation of subaltern resistance in practices of human rights. It critiques the normative framing of the subaltern by those practices, a framing which it argues contributes to their subjugation. Against such framing, the article follows the 2011 Egyptian uprising through the film Rags & Tatters, offering a practice of freedom beyond human rights and through self-recollection.
Effects of Neural Mobilization on Sensory Dysfunction and Peripheral Nerve Degeneration in Rats With Painful Diabetic Neuropathy
Authors: Zhu Guan-Cheng , Chen Yu-Wen , Tsai Kun-Ling , Wang Jhi-Joung , Hung Ching-Hsia , Schmid Annina B 
Published: August 2022

Abstract

Objective
This study aims to evaluate the effectiveness of neural mobilization (NM) in the management of sensory dysfunction and nerve degeneration related to experimental painful diabetic neuropathy (PDN).

Methods
This is a pre-clinical animal study performed in the streptozocin-induced diabetic rat model. Three groups were included: a treatment group of rats with PDN receiving NM under anesthesia (PDN-NM, n = 10), a sham treatment group of rats with PDN that received only anesthesia (PDN-Sham, n = 9), and a vehicle control group with nondiabetic animals (Vehicle, n = 10). Rats in the PDN-NM and PDN-Sham groups received 1 treatment session on days 10, 12, and 14 after streptozocin injection, with a 48-hour rest period between sessions. Behavioral tests were performed using von Frey and Plantar tests. Evaluation for peripheral nerve degeneration was performed through measuring protein gene product 9.5-positive intra-epidermal nerve fiber density in hind-paw skin biopsies. All measurements were performed by a blinded investigator.

Results
The behavioral tests showed that a single NM session could reduce hyperalgesia, which was maintained for 48 hours. The second treatment session further improved this treatment effect, and the third session maintained it. These results suggest that it requires multiple treatment sessions to produce and maintain hypoalgesic effects. Skin biopsy analysis showed that the protein gene product 9.5-positive intra-epidermal nerve fiber density was higher on the experimental side of the PDN-NM group compared with the PDN-Sham group, suggesting NM may mitigate the degeneration of peripheral nerves.

Conclusion
This study demonstrated that NM may be an effective method to manage experimentally induced PDN, potentially through mitigation of nerve degeneration. Further studies are needed to develop standardized protocols for clinical use.

Impact
These findings provide neurophysiological evidence for the use of NM in PDN and can form the basis for the development of physical therapy-based programs in clinics.
Mitochondria-targeting polydopamine-coated nanodrugs for effective photothermal- and chemo-synergistic therapies against lung cancer
Authors: Meng Ziyu , Wang Binchao , Liu Yiqiang , Wan Yejian , Liu Qianshi , Xu Huasheng , Liang Renchuan , Shi Ying , Tu Peng , Wu Hong , Xu Chuan 
Published: August 2022

Abstract
Targeting mitochondria via nano platform emerged as an attractive anti-tumor pathway due to the central regulation role in cellar apoptosis and drug resistance. Here, a mitochondria-targeting nanoparticle (TOS-PDA-PEG-TPP) was designed to precisely deliver polydopamine (PDA) as the photothermal agent and alpha-tocopherol succinate (α-TOS) as the chemotherapeutic drug to the mitochondria of the tumor cells, which inhibits the tumor growth through chemo- and photothermal- synergistic therapies. TOS-PDA-PEG-TPP was constructed by coating PDA on the surface of TOS NPs self-assembled by α-TOS, followed by grafting PEG and triphenylphosphonium (TPP) on their surface to prolong the blood circulation time and target delivery of TOS and PDA to the mitochondria of tumor cells. In vitro studies showed that TOS-PDA-PEG-TPP could be efficiently internalized by tumor cells and accumulated at mitochondria, resulting in cellular apoptosis and synergistic inhibition of tumor cell proliferation. In vivo studies demonstrated that TOS-PDA-PEG-TPP could be efficiently localized at tumor sites and significantly restrain the tumor growth under NIR irradiation without apparent toxicity or deleterious effects. Conclusively, the combination strategy adopted for functional nanodrugs construction aimed at target-delivering therapeutic agents with different action mechanisms to the same intracellular organelles can be extended to other nanodrugs-dependent therapeutic systems.
Three-year Retention Rates With Office-based Treatment of Buprenorphine for Opioid Use Disorder in a Private Family Medicine Practice
Authors: Cope Kevin , DeMicco James , Salib Justina , Michael Mina , Yakoub Peter , Daoud Kirollos , Cope Rebecca 
Published: August 2022

Objective
Although primary care settings have benefits for implementing office-based opioid treatment (OBOT) programs with buprenorphine, few studies have examined the impact on patient retention beyond 12 months. The objective of this study is to assess long-term outcomes of buprenorphine treatment for opioid use disorder (OUD) integrated into comprehensive primary care treatment at a family medicine practice.

Methods
A retrospective chart review of patients diagnosed with OUD who received treatment with buprenorphine between December 2006 and January 2018 was conducted at private family medicine practice in semirural Upstate New York. Patients were seen continuously by the same provider. The primary outcome was retention in OBOT at 3 years.

Results
The primary outcome was met by 47.4% of included patients (N = 152). Mean retention in care for all patients was 24.3 months. More than three quarters of patients (77%) had a least one psychiatric comorbidity managed by the practice, most commonly depression (59.9%). Self-reported history of intravenous drug use at baseline was associated with a higher likelihood of patient dropout at year 1 (odds ratio, 2.99; 95% confidence interval, 1.39–6.44; P = 0.004) and year 2 (odds ratio, 2.46; 95% confidence interval, 1.15–5.28; P = 0.019), with no difference observed at year 3.

Conclusions
Office-based opioid treatment with buprenorphine in a family medicine practice setting resulted in high retention rates, emphasizing the importance of continuity of care and integration of primary care within the OUD treatment model. Further research is needed on barriers to implementation of OBOT among family medicine providers.
Addiction Services for Veterans: Opportunities in Acute Care
Authors: Shah Meghna N. , Starks Helene , Wander Pandora L. , Saxon Andrew J. 
Published: August 2022

Objective
This study aimed to estimate the proportion of total hospital discharges that involved a primary or secondary substance-related diagnosis code (SubDx) on inpatient medicine, psychiatry, and surgery services as part of a needs assessment for inpatient addiction consultation at our large, academic-affiliated Veterans Affairs (VA) hospital.

Methods
We first calculated the percentage of total and service-specific discharges with a primary or secondary substance-related International Classification of Disease, Tenth Revision, code on all inpatient services (medicine, psychiatry, and surgery) in Fiscal Year 2017, 2018, and 2019, using facility-level data. Second, we calculated the proportion of total discharges that involved alcohol- and opioid-related diagnoses.

Results
Over the 3 years studied, 29% of total discharges had a SubDx (4469 of 15,575). The proportion of total discharges that involved a SubDx was 23% (1246 of 5449) in 2017, 31% (1664 of 5332) in 2018, and 33% in 2019 (1559 of 4794), a statistically significant increase (P < 0.001). As a percentage of service-specific discharges, 65% of discharges from psychiatry (1446 of 2217) had a SubDx, compared with 25% from medicine (2469 of 9713), and 15% from surgery (554 of 3645). Medicine services had the most discharges with SubDx, with a year-over-year increase in the number of discharges with SubDx. The percentage of total discharges that involved alcohol- and opioid-related diagnoses was 14% and 4%, respectively.

Conclusions
Substance-related diagnoses are prevalent at our hospital and are increasing over time. The largest number of discharges with SubDx was found on medicine services. Alcohol-related diagnoses were nearly 4 times more prevalent than opioid-related diagnoses. We found focused need around alcohol use and alcohol withdrawal.
Will the new treatment recommendations for asthma increase adverse events?
Authors: Dalin Dagmar A. , Koch Nicoline E. , Hilberg Ole 
Published: August 2022

Summary
The Global Initiative for Asthma has since 2019 recommended as-needed inhaled steroids (ICS)/formoterol either alone or in combination with ICS/long-acting β2-agonists (LABA) maintenance for mild to moderate asthma. This might give patients more adverse effects by using LABA instead of short-acting β2-agonists (SABA) and by using ICS as needed where the patient might not be able to wash their mouth after use. The objective of this study is through a literature review to investigate whether the new recommendations increase the incidence of adverse events. We included 15 randomized clinical trials. They showed no increase in adverse events with as-needed ICS/formoterol only compared with either as-needed SABA only or maintenance ICS and SABA as-needed, and even a small tendency to less adverse events. When comparing as-needed and maintenance ICS/formoterol with as-needed SABA and maintenance ICS/LABA a small increase was seen for some adverse events, especially candidiasis (1.4 vs. 0.7%) and dysphonia (1.5 vs. 1.0%). In conclusion, the new treatment with as-needed ICS/formoterol only is at least as safe as the previously recommended treatment, regarding adverse effects. ICS/formoterol used as needed and maintenance might give an increased risk of candidiasis and dysphonia, though the absolute risk remains low.
Association Between Working Hours and Poor Glycemic Control in Patients With Diabetes
Authors: Seo Eunhye , Lee Yesung , Lee Woncheol 
Published: August 2022

Objective
This study aimed to evaluate the relationship between working hours and glycemic control.

Methods
Study was performed among Korean participants who underwent at least two health screening examinations between 2012 and 2018. The study included 2169 participants who were older than 40 years and undergoing treatment for diabetes at baseline. A hemoglobin A1c level >9% at the follow-up visit was defined as poor glycemic control. The weekly working hours were divided into three groups for analysis.

Results
Compared with participants with 45–54 weekly working hours, multivariate-adjusted hazard ratios (95% confidence intervals) for incident poor glycemic control among participants with ≥55 and 35–44 working hours were 1.40 (1.01–1.96) and 1.51 (1.09–2.09), respectively.

Conclusions
Standard working hours and long working hours were independent risk factors for poor diabetes control in patients with diabetes.
The Effects of Visual Field Loss from Stroke on Performance in a Driving Simulator
Authors: Bro Tomas , Andersson Jan 
Published: August 2022

ABSTRACT

SIGNIFICANCE
Visual field loss is a common consequence of stroke and often precludes driving. However, legal visual requirements for drivers' licenses are largely without scientific basis.

PURPOSE
This study aimed to examine the effects of different types of homonymous visual field loss after stroke on simulated driving.

METHODS
Data on performance and safety from a traffic simulator test for 153 participants with withdrawn drivers' licenses due to visual field loss from stroke were retrospectively compared with data from 83 healthy individuals without visual deficits in a cross-sectional study. The 93 individuals in the stroke group who regained their driving licenses after a successful simulator test were then followed in a national accident database.

RESULTS
Sixty-five percent of the stroke participants passed the simulator test (95% confidence interval, 57 to 72%). Younger patients were more successful than older. However, classification by neither type of homonymous visual field loss nor side of visual field loss was predictive of driver safety. Participants with hemianopia had their lateral lane position dislocated to the nonaffected side of the visual field. None of the participants with a regained license were involved in motor vehicle accidents 3 to 6 years after the test.

CONCLUSIONS
In this large cohort, driver safety could not be predicted from the type of homonymous visual field loss. Even individuals with severe visual field loss might be safe drivers. Therefore, it seems reasonable to provide an opportunity for individualized assessments of practical fitness to drive in circumstances of licensing issues. This study demonstrates the potential of using a standardized driving simulator test for such assessments of fitness to drive.
Relationships among Clinical Factors and Patient-reported Outcome Measures in Adults with Convergence Insufficiency
Authors: Lorenzana Ingryd J. , Leske David A. , Hatt Sarah R. , Dean Trevano W. , Jenewein Erin C. , Dagi Linda R. , Beal Casey J. , Pang Yi , Retnasothie Dashaini V. , Esposito Christina A. , Erzurum S. A. , Aldrich Amy E. , Crouch Eric R. , Li Zhuokai , Kraker Raymond T. , Holmes Jonathan M. , Cotter Susan A. 
Published: August 2022

SIGNIFICANCE
When exploring relationships among clinical measures and patient-reported outcome measures in adults with convergence insufficiency, worse symptoms (Convergence Insufficiency Symptom Survey [CISS] score) seemed to be correlated with worse reading function domain score (Adult Strabismus-20 quality-of-life questionnaire). After treatment, improved symptoms were associated with improved reading function quality of life.

PURPOSE
This study aimed to explore relationships between clinical measures and patient-reported outcome measures in adults undergoing treatment for symptomatic convergence insufficiency.

METHODS
In a prospective multicenter observational study, we evaluated adults with symptomatic convergence insufficiency (i.e., clinical measures of near exodeviation, receded near point of convergence, reduced near positive fusional vergence; CISS score ≥21). Fifty-seven participants treated with vision therapy/exercises (n = 35) or base-in prism (n = 22) were analyzed. Spearman correlation coefficients (R) were used to assess associations among the three clinical measures and patient-reported outcome measures (CISS, Diplopia Questionnaire, four Adult Strabismus-20 quality-of-life domains) before treatment (baseline) and after 10 weeks and 1 year. Associations were interpreted to be present when the lower limit of the 95% confidence interval (CI) was moderate to strong (R ≥ 0.4).

RESULTS
Among multiple exploratory analyses, the only moderate to strong baseline correlation was between worse CISS and worse Adult Strabismus-20 reading function scores (R = 0.62; 95% CI, 0.43 to 0.76). Regarding change in measures with treatment, the only moderate to strong correlations were between improved CISS and improved Adult Strabismus-20 reading function scores for prism at 10 weeks (R = 0.78; 95% CI, 0.52 to 0.91) and 1 year (R = 0.85; 95% CI, 0.65 to 0.94) and for vision therapy/exercises at 1 year (R = 0.78; 95% CI, 0.57 to 0.89).

CONCLUSIONS
In exploratory analyses, we found positive correlations between CISS symptom scores and reading function quality-of-life scores. The absence of correlations between symptoms and individual clinical measures is consistent with clinical experience that, in convergence insufficiency, symptoms and clinical findings can be discordant.