bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep Learning-Generated Radiographic Hip Dysplasia Parameters: Relationship to Postoperative Patient-Reported Outcome Measures
Authors: Reine Seth , Archer Holden , Alshaikhsalama Ahmed , Wells Joel , Kohli Ajay , Xi Yin , Chhabra Avneesh 
Published: August 2022

Abstract
Background
Hip dysplasia (HD) causes accelerated osteoarthrosis of the acetabulum and is diagnosed through radiographic evaluation. An artificial intelligence (AI) program capable of measuring the necessary anatomical landmarks relevant to HD could reduce resource utilization, increase standardized HD screenings, and form HD outcome models. The study's aim was to evaluate the relationship between AI measurements of dysplastic hips on initial presentation and changes in patient-reported outcome measures following surgical intervention for HD.
Methods
One hundred nine patients with HD and planned surgical intervention obtained preoperative anterior-posterior pelvic radiographs which were measured by the HIPPO AI for lateral center edge angle, Tönnis angle, Sharp angle, Caput-Collum-Diaphyseal angle, femoral coverage, femoral extrusion, and pelvic obliquity. Patients completed a preoperative survey containing the 12-Item Short Form, EuroQol Visual Analog Scale (EQVAS), International Hip Outcome Tool (iHOT-12), Harris Hip Score, and Visual Analog Pain Scales. Patients were recommended to follow up at four months and one year to complete the same survey. Changes in outcome measures were evaluated with paired t-tests for each follow-up interval. Partial Spearman Rank-order correlations were performed between radiographic measures and changes in outcome measures at each follow-up interval controlling for age, BMI, and follow-up time.
Results
Patients had significant improvement in all outcome measures at four months (N = 46,p-values < 0.05) and one year (N = 49,p-values < 0.001), except one-year EQVAS (p-value = 0.090). Significant positive correlation of moderate strength existed between the Sharp angle and iHOT-12 at four months postoperatively (rs=0.472,p-value = 0.044). No other significant correlations were found at either follow-up interval between HIPPO measures and outcome measures.
Conclusion
Correlations between deep learning radiographic measurements of dysplastic hips and improvements in postoperative outcomes as evaluated by outcome measures lacked any significant relationships in this study. Physicians treating HD patients can augment care with AI tools but outcomes are likely more multi-factorial and require multi-disciplinary patient care.
Factors impacting HIV testing among young women migrant workers in Vietnamese industrial zones
Authors: Ha Toan H. , Shi Hui , Givens David , Nguyen Trang , Nguyen Nam 
Published: August 2022

Abstract
Background. Young migrant workers living in low- and middle-income countries often experience the barriers and inadequate access to HIV prevention and treatment services. This study examines the prevalence of HIV testing, associated factors and reasons for obtaining and not obtaining HIV testing among young women migrant workers working in the industrial zones in Hanoi, Vietnam. Methods. A cross-sectional study was conducted among 1061 young women migrant workers (aged 18 to 29) working in the Thang Long industrial zone in Hanoi, Vietnam. Data were collected via a face-to-face interview from January 2020 to June 2021. Multivariable logistic regression analysis was used to explore factors associated with ever-testing for HIV Results. The study found a low level of HIV testing and high rates of unprotected sex; only 18.7% of participants reported having ever tested for HIV. Among those who reported never having tested for HIV, 46.4% said they had ever had sex, and 38.8% reported not using condoms during their most recent sexual encounter. Factors associated with prior testing for HIV included older age, being married, higher HIV knowledge, having sex with and without condoms, and prior use of sexual and reproductive health and HIV services. Conclusions. Overall, a low level of HIV testing, high rates of unprotected sex and low perceived risk of HIV among study participants point to a need to implement targeted HIV interventions that can improve safe sex practices and perceptions of risky sexual behaviors, as well as take into consideration factors facilitating HIV testing HIV testing among industrial zones women migrant workers.
TrkC, as a Novel Prognostic Marker, Induces and Maintains the Cell Survival and Metastatic Dissemination of Ewing Sarcoma by Inhibiting EWS-FLI1 Degradation
Authors: Kim MinSoo , Lee Won Sung , Lee Hanki , Jin Wook 
Published: August 2022

Abstract
Upregulation of EWS-FLI1 expression has been associated with invasiveness, induced cell survival, metastatic dissemination, and acquisition of self-renewal traits in Ewing sarcoma (ES). Although increasing evidence implies that TrkC expression is linked to the pathogenesis of other cancer types, its role in the mediation of ES pathology is still unknown, and the mechanism behind the correlation between TrkC and EWS-FLI1 remains unclear. Here, we uncovered a novel, unexpected physiological role of TrkC as a key regulator of EWS-FLI1 in the survival and metastatic dissemination of ES. In this study, TrkC was frequently overexpressed in human metastatic ES cells in vitro and in vivo, leading to remarkable enhanced survival, tumorigenicity, and metastatic ability of ES cells. TrkC also enhanced the metastatic potential of ES cells by inhibiting the proteasomal degradation of EWS-FLI1 via the formation of a TrkC/EWS-FLI1 complex and subsequently enabled the induction of EGR2 and NKX2.2 as target proteins of EWS-FLI1 to induce the proliferation and metastatic ability of ES cells. Moreover, TrkC-induced stabilization of EWS-FLI1 resulted in reduced TGFBR2 expression and inhibited tumor suppressor activity by TGF-β. Furthermore, loss of TrkC expression inhibited tumor growth and metastasis in an experimental mouse model. This study is the first to report the involvement and functional role of TrkC in the pathogenesis of ES, suggesting important implications for understanding the alterations of TrkC in Ewing tumors.
Paremeter choice strategies and the numerical stability of Tikhonov regularized approximation formulae
Authors: Tian Lin 
Published: August 2022

Abstract
The paper concerns the Tikhonov regularized approximation formulae derived by the authors (An and Wu, Inverse Problems 37(1), 015008 (2020)). First, we give more specific an L2 error bound and a uniform error bound of the Tikhonov regularized approximation polynomial. From these two error bounds, we know that a regularization parameter in this approximation polynomial is important. Then, we employ two strategies, the balancing principle and Brezinski– Rodriguez–Seatzu estimators, to select the regularization parameter. Some numerical experiments are given to illustrate that both parameter choice strategies can select suitable regularization parameters. The two parameter choice strategies are also compared by testing some oscillatory functions. Finally, we study the numerical stability of Tikhonov regularized barycentric interpolation formula and Tikhonov regularized modified Lagrange interpolation formula. Both interpolation formulae are shown to be forward stable, and the Tikhonov regularized modified Lagrange interpolation formula is also backward stable. We give numerical examples to illustrate the theoretical results.
Preferred Cataract Surgery Practices in Malaysia: A Survey of Malaysian Young Ophthalmologists Special Interest Group 2021
Authors: Wai Yong Zheng , Chong Yong Yuin , Lim Lik Thai , Chan Jan Bond , Chandrasekaran Sudhashini 
Published: August 2022

Abstract
Background:
To describe the preferred cataract surgery practices among Malaysian ophthalmologists and medical officers in comparison with the recommended practices.
Methods:
An online questionnaire was sent out in April 2021, to Malaysian Ophthalmologists and medical officers who perform cataract surgeries. The questions were focused on the preferred cataract surgery practices of the participants. All data obtained were collected, tabulated and analysed.
Results:
A total of 173 participants responded to the online questionnaire. 55% of the participants were within 31–40 years of age. 56.1% preferred peristaltic pump over venturi system. 91.3% of participants practised povidone iodine instillation to the conjunctival sac. With regards to the main wound incision, more than half of the surgeons (50.3%) preferred fixed superior incision and 72.3% of them preferred 2.75mm microkeratome blade. Most of the participants (63%) were inclined towards C-Loop clear intraocular lens (IOL) with a single-handed push preloaded system. 78.6% of the surgeons routinely use carbachol in their cataract surgery.
Conclusions:
This survey provides some insight into the current practices among Malaysian ophthalmologists. Most of the practices are in line with international guidelines for preventing postoperative endophthalmitis. This article could help trainees and ophthalmologists benchmark and observe the common cataract surgery practices among their seniors and peers in Malaysia.
Synthesis, computational and biological evaluation of some new pyridine Derivatives
Authors: Alsoliemy Amerah 
Published: August 2022

Abstract
A series of pyridine compounds was prepared by using "3-(dimethylamino)-1-(pyridin-4-yl)prop-2-en-1-one" (14) as precursor. Reaction of 14 with different reagents afforded different new heterocyclic compounds. All the new compounds were characterized by spectroscopic analyses. Moreover, study of Density Function Theory (DFT) was mentioned to establish the geometry of the tested compounds. The antimicrobial activities of the newly prepared pyridine derivatives were studied against Gram positive bacteria (B. subtilis and B. thuringiensis) and Gram-negative bacteria (E. Coil and P. aerugunosa) and fungi (F. oxysporum and B. Fabae) by MIC method. Compounds belonging to pyran 32, pyridine 33, indenopyran 34, thiazolopyridine 35 and chromene 39 series displayed a high antimicrobial activity. It was found that, the experimental results of biological evaluation were in agreement with their molecular modeling study.
MRI-based deep learning nomogram for prediction of early metachronous liver metastases in rectal cancer
Authors: Zhao Rui , Wan Lijuan , Chen Shuang , Peng Wenjing , Zhao Qing , Ye Feng , Zhao Xinming , Zhang Hongmei 
Published: August 2022

Abstract
Background
To investigate the potential of deep learning nomogram based on MRI for predicting early metachronous liver metastases (EMLM) in patients with rectal cancer.
Methods
A total of 170 patients with rectal cancer were enrolled and divided into training (2,080 images and later augmented to 12,480 images, 130 patients) and test (640 images, 40 patients) sets. A deep learning model was developed based on T2WI images using a 3D residual network (3D-ResNet). A clinical model based on independent predictors was then constructed via multivariate logistic regression. The nomogram was constructed by integrating the deep learning model with clinical model.
Results
The deep learning model exhibited good performance with AUCs of 0.856 and 0.812 in the training and test sets, respectively. Multivariate logistic regression revealed that mr-N stage (OR, 2.260; 95% CI: 1.322–3.865; p = 0.003) and mr-EMVI (OR, 2.682; 95% CI: 1.204–5.976; p = 0.016) were independent predictors of EMLM. The clinical model based on mr-N stage and mr-EMVI was developed with AUCs of 0.738 and 0.754 in the training and test sets, respectively. A nomogram was constructed based on three variables: deep learning signature, mr-N stage, and mr-EMVI. The AUCs of the nomogram were 0.906 and 0.895 in the training and test sets, respectively. The predictive performance of the nomogram was significantly superior to that of the clinical model and the deep learning model in both the training and test sets (p < 0.05).
Conclusions
The nomogram combining deep learning signature, mr-N stage and mr-EMVI may aid in the clinical prediction of EMLM in patients with rectal cancer.
Heparin-perfusion therapy for thrombosis of the intra- and extrahepatic portal and mesenteric vein.
Authors: Misbahuddin-Leis Mohammed , Ademi Burhan , Ankolvi Muzaffer , Dubasz Krisztina , Mishra Manisha , Riechmann Maren , Graeb Christian , Radeleff Boris 
Published: August 2022

Abstract
Background:Although as stated many times in the literature, the initial treatment of acute and subacute portal vein thrombosis (PVT) consists of intravenous anticoagulation with heparin, but there is still a huge uncertainty among physicians regarding whether the patient should be better taken to more invasive therapies. Case Presentation:We henceforth report on a 61-year-old patient, who presented in our emergency room with a subacute thrombosis of the intra- and extrahepatic portal and superior mesenteric vein (SMV) and venous congestion of 20-30 cm of the small intestine with a quick and complete remission of the PVT under sole i.v. Heparin-perfusor therapy with repetitive CT-follow-ups without any complications. Molecular genetic analysis found combined genetic mutations of the gene factor 2 (c.20210G>A, heterozygotic), SERPINE1 (-675 5G>4G, heterozygotic), and the MTHFR gene.Conclusion:Early diagnosis and immediate initiation of heparinization in patients with PVT and SMVT, could not only reverse the initial intestinal ischemia but also suffice as the sole mode of treatment, preventing the subsequent need for radiological and surgical interventions. Furthermore, molecular genetic counseling should be always taken under consideration when the cause of PVT remains unknown
RRSC-128AEAD: An Efficient Randomized Lightweight Stream Cipher Supports Authenticated Encryption with Associated Data
Authors: Chatterjee Runa , Chakraborty Rajdeep , Elngar Ahmed A. 
Published: August 2022

Abstract
A proposed stream cipher, RRSC-128AEAD, supports authenticated encryption with associated data (AEAD) for checking both the authenticity and integrity of the message. This cipher includes a key and a nonce of size 128-bit each as input. It produces two different pseudo-random bit streams in parallel. One is used for encryption and another one is used for authentication purposes. It generates 64-bit MAC, based on the National Institute of Standards and Technology standardized (NIST) value, for lightweight security. The cipher efficiency in terms of randomness is analyzed by an online NIST statistical test suite. The design is compared with NIST standardized stream cipher GRAIN-128AEAD. The proposed cipher proves its efficiency in key reintroduction and probability of avoiding key leakage compared to GRAIN-128AEAD. Although both cipher initialization times are the same, some features like two independent bit streams, large internal states, and variable-length associated data and masking technique together made this proposed cipher stronger and more efficient against various types of attacks.
Novel function of a putative TaCOBL ortholog associated with cold response
Authors: Liu Fangfang , Wan Ying-Xiu , Cao Wen-Xin , Zhang Qi-Qi , Li Yao , Li Yan , Zhang Ping-Zhi , Si Hong-Qi 
Published: August 2022

Abstract
Background The cell wall plays crucial roles in establishing the morphology of plant cells and defense response to biotic and abiotic stresses. The plant COBRA protein family plays an important role in secondary cell wall biosynthesis and the orientation of cell expansion, which have been extensively studied in Arabidopsis thaliana, maize, rice, etc., but no systematic studies were conducted in wheat. Methods and Results In this study, the full-length sequence of TaCOBLs was obtained by homology cloning from wheat, and a conserved motif analysis confirmed that TaCOBLs belonged to the COBRA protein family. qRT-PCR results showed that the TaCOBL transcripts were induced by abiotic stresses, including cold, drought, salinity, and abscisic acid (ABA). Two haplotypes of TaCOBL-5B (Hap5B-a and Hap5B-b), harboring one indel (----/TATA) in the 5’ flanking region (-550 bp), were found on chromosome 5BS. A co-dominant marker, Ta5BF/Ta5BR, was developed based on the polymorphism of the two TaCOBL-5B haplotypes. Significant correlations between the two TaCOBL-5B haplotypes and cold resistance were observed under four environmental conditions. Conclusion Hap5B-a, a favored haplotype acquired during wheat polyploidization, may positively contribute to enhanced cold resistance in wheat. Based on the promoter activity analysis, the Hap5B-a promoter containing a TATA-box was more active than that of Hap5B-b without the TATA-box under low temperature. Our study provides valuable information indicating that the TaCOBL genes are associated with cold response in wheat.
A unified earthquake catalog for Northern Algeria based on an advanced moment magnitude scale using a robust regression method
Authors: Boudebouda Afaf , Athmani Allaeddine , Das Ranjit 
Published: August 2022

Abstract
The establishment of a homogenous earthquake catalog is a basic requirement for attaining a detailed seismological analysis and an improved seismic hazard assessment. Accordingly, the current research paper aims to present a reliable instrumental homogeneous earthquake catalog for the northern part of Algeria. This unified catalog is compiled using regional empirical relationships derived from converting different magnitude scales to an advanced physical-based moment magnitude scale suggested in the recent literature and denoted by Mwg. The regression methodology used in this study is called the New General Orthogonal Regression approach (N.GOR), which was selected since it is the most trustworthy procedure for scaling the magnitudes to Mwg. To highlight the significance of using the N.GOR, the obtained outcomes of the scaling relations were compared with those issued from the conventional general orthogonal regression (GOR) method, which is deemed to be the most dependable methodology used worldwide for magnitude conversion problems. The unified earthquake catalog was assembled from 1954 to 2022. Reliably converting the original magnitudes into homogenized moment magnitude leads to a complete and consistent unified earthquake catalog. Indeed, the homogenized moment magnitude catalog presented in this paper could provide reliable data for studying earthquakes distribution and the assessment of seismic hazards in the north of Algeria.
Assessment of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients with High Myopia
Authors: Wang Xin , He Qing , Zhao Xiaoyu , Li Haoru , Liu Lin , Wu Di , Wei Ruihua 
Published: August 2022

Abstract
BackgroundPrevious reports have suggested that inflammation levels play a crucial role in the pathogenesis of high myopia (HM). The aim of this study was to investigate the relationship between HM and systemic inflammation using the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR).MethodsOverall, 100 age- and sex-matched participants were recruited for the study, including 50 eyes in the non-HM (NHM) group and 50 eyes in the HM group. Ocular examinations and blood tests were performed. The NLR and PLR values were calculated from complete blood counts. Receiver operating characteristic (ROC) curves and optimal cut-off values were used to determine the optimal values of the NLR and PLR to distinguish between the HM and NHM groups.ResultsThe values of NLR and PLR were significantly elevated in the HM group compared with those in the NHM group (P < 0.001 and P = 0.010, respectively). Axial length (AL) was significantly correlated with the NLR (r = 0.367, P < 0.001) and PLR (r = 0.262, P = 0.009). In the ROC analysis, the NLR value to distinguish between the HM and NHM groups was 0.728; the best cut-off value was 2.68, with 76% sensitivity and 62% specificity. The PLR value to distinguish between the HM and NHM groups was 0.650; the best cut-off value was 139.69, with 52% sensitivity and 76% specificity.ConclusionThe findings of this study indicate that the development of HM may be associated with systemic inflammation measured using the NLR and PLR.Trial Registration: The study was registered on December 28, 2021 (http://www.chictr.org.cn; ChiCTR2100054834).
A Positive Feedback Loop of E2F4-Mediated Activation of MNX1 Regulates Tumour Progression in Colorectal Cancer
Authors: Li Jia-Ke , Liu Hai , Zhang Hui-Wen , Li Jun , Liang Zhuo-Tao 
Published: August 2022

Abstract
Purpose
Colorectal cancer (CRC) is the 3rd most prevalent malignant tumour globally. Although significant strides have been made in diagnosis and treatment, its prognosis at the moment remains unpromising. Therefore, there is an urgent and desperate need to identify novel biomarkers of CRC and evaluate its mechanism of tumourigenesis and development.
Methods
JASPAR and RNAinter databases are used to analyze target genes associated with colorectal cancer. Western blotting, q-PCR and immunohistochemistry et, al. were used to detect the level of MNX1 in patients with colorectal cancer, and Chip-PCR was used to detect the targeted binding ability of E2F4 and MNX1. The cells and animal models overexpressed MNX1 and E2F4 were constructed by siRNA transfection.
Results
Herein, MNX1 was highly expressed and linked to favourable overall survival curves in colorectal cancer. The functional assay revealed that MNX1 overexpression could promote proliferation, migration, and invasion of CRC cells. Based on the prediction of the JASPAR and RNAinter databases, the transcription factor, E2F4, was bound to the MNX1 promoter region. The Chromatin Immunoprecipitation (ChIP) assay verified the interactions between MNX1 and E2F4 in CRC. Additionally, we found that sh-E2F4 markedly downregulated the MNX1 levels and reduced CRC progression in vivo and in vitro, which reversed MNX1 overexpression.
Conclusion
Therefore, our research discovered that E2F4-mediated abnormal MNX1 expression promotes CRC progression and could become a novel diagnostic or therapeutic target of CRC.