bluuebunny/crossref_metadata_2025_split huggingface dataset:
K Value: An Indicator that can Characterize the Cold and Hot Properties of Traditional Chinese Medicines
Authors: Yang Meina , Pang Jingxiang , Zhang Zhongwen , Fu Jialei , Fan Hua , Zhang Yufeng , Min Lingyuan , Zhou Baochen , Han Jinxiang 
Published: May 2022

Aims: The cold and hot properties of Chinese medicines are an important concept to represent the function of drugs, and are also a unique classification method of traditional Chinese medicine (TCM). The method reflects an herb’s therapeutic properties and guides reasonable clinical prescription. However, the present key problem is the lack of an objective and quantitative evaluation index for the cold and hot properties of Chinese herbs. Delayed luminescence (DL) is the long-term afterglow of biological systems after illumination with light, which can reflect differences in herbal materials prepared under different conditions. We aim to use S. obliquus as an indicator organism to characterize the differences between the cold and hot properties of Chinese herbs.Methods: Scenedesmus obliquus (S. obliquus) was used as an indicator organism to characterize the differences between the cold and hot properties of Chinese herbs. The decoction solution of different properties of Chinese herbs was added to S. obliquus culture medium; then, the delayed luminescence (DL) of S. obliquus after the addition of decoctions of different properties of Chinese herbs was measured to obtain information on the effect of different properties of Chinese herbs on S. obliquus. Many DL parameters were calculated, and ROC curve analysis was applied with the aim of finding a suitable parameter that can characterize the differences in cold and hot properties of Chinese herbs.Results: Our results show that the K value is a sensitive parameter that can reflect the differences of cold and hot properties of Chinese herbs, thus providing new insights into the cold and hot properties of Chinese herbs.Conclusions: DL measurement of S. obliquus after addition of different properties of Chinese herbs could be a novel and promising method to study the cold and hot properties of Chinese herbs.
Fragmentation Dynamics of Fluorene Explored Using Ultrafast XUV-Vis Pump-Probe Spectroscopy
Authors: Garg D. , Lee J. W. L. , Tikhonov D. S. , Chopra P. , Steber A. L. , Lemmens A. K. , Erk B. , Allum F. , Boll R. , Cheng X. , Düsterer S. , Gruet S. , He L. , Heathcote D. , Johny M. , Kazemi M. M. , Köckert H. , Lahl J. , Loru D. , Maclot S. , Mason R. , Müller E. , Mullins T. , Olshin P. , Passow C. , Peschel J. , Ramm D. , Rompotis D. , Trippel S. , Wiese J. , Ziaee F. , Bari S. , Burt M. , Küpper J. , Rijs A. M. , Rolles D. , Techert S. , Eng-Johnsson P. , Brouard M. , Vallance C. , Manschwetus B. , Schnell M. 
Published: May 2022

We report on the use of extreme ultraviolet (XUV, 30.3 nm) radiation from the Free-electron LASer in Hamburg (FLASH) and visible (Vis, 405 nm) photons from an optical laser to investigate the relaxation and fragmentation dynamics of fluorene ions. The ultrashort laser pulses allow to resolve the molecular processes occurring on the femtosecond timescales. Fluorene is a prototypical small polycyclic aromatic hydrocarbon (PAH). Through their infrared emission signature, PAHs have been shown to be ubiquitous in the universe, and they are assumed to play an important role in the chemistry of the interstellar medium. Our experiments track the ionization and dissociative ionization products of fluorene through time-of-flight mass spectrometry and velocity-map imaging. Multiple processes involved in the formation of each of the fragment ions are disentangled through analysis of the ion images. The relaxation lifetimes of the excited fluorene monocation and dication obtained through the fragment formation channels are reported to be in the range of a few tens of femtoseconds to a few picoseconds.
Heat Stress-Mediated Constraints in Maize (Zea mays) Production: Challenges and Solutions
Authors: El-Sappah Ahmed H. , Rather Shabir A. , Wani Shabir Hussain , Elrys Ahmed S. , Bilal Muhammad , Huang Qiulan , Dar Zahoor Ahmad , Elashtokhy Mohamed M. A. , Soaud Nourhan , Koul Monika , Mir Reyazul Rouf , Yan Kuan , Li Jia , El-Tarabily Khaled A. , Abbas Manzar 
Published: May 2022

Graphical AbstractThis review summarized heat stress-mediated morphological and physiological changes in maize and elucidated the molecular mechanisms responsible for maize response to heat stress. Furthermore, plausible approaches to dissecting the regulatory network associated with heat stress response and improving maize adaptation to global warming have been discussed. This figure was made using BioRender.
Self-Efficacy, Proxy Efficacy, Media Literacy, and Official Media Use in COVID-19 Pandemic in China: A Moderated Mediation Model
Authors: Li Qingrui , Zheng Yu , Zhang Junqing , Geng Rui 
Published: May 2022

PurposeCOVID-19 pandemic is a significant threat toward the public health. However, the discussion of the mechanism of media literacy’s effect in fighting against pandemic is limited. Thus, this study aims to explore the mechanism with a sociocognitive perspective.MethodsA survey was administrated to 420 college students in China. PROCESS macro of SPSS was applied to analyze the data and test the moderated mediation effect.ResultsThe moderated mediation model of media literacy, proxy efficacy, self-efficacy, and official media use was tested and supported. Official media use was a negative moderator on the association between media literacy and proxy efficacy.ConclusionThe study explored the media literacy’s role as a determinant of proxy efficacy and self-efficacy, which contributed to the sociocognitive theory.
The Global Landscape of the Burden of Depressive Symptoms/Major Depression in Individuals Living With HIV/AIDs and Its Effect on Antiretroviral Medication Adherence: An Umbrella Review
Authors: Necho Mogesie , Zenebe Yosef , Tiruneh Chalachew , Ayano Getinet , Yimam Bethlehem 
Published: May 2022

BackgroundPeople living with HIV/AIDS have a higher rate of depression/depressive symptoms and this highly affects antiretroviral medication adherence. Therefore, much stronger evidence weighing the burden of depressive symptoms/major depression is warranted.MethodsWe investigated PubMed, Scopus, Psych-Info, and Embase databases for systematic review studies. A PRISMA flow diagram was used to show the search process. We also used the Assessment of Multiple Systematic Reviews (AMSTAR) checklist scores. A narrative review and statistical pooling were accompanied to compute the pooled effect size of outcome variables.ResultsOverall, 8 systematic review studies addressing 265 primary studies, 4 systematic review studies addressing 48 primary studies, and six systematic review studies addressing 442 primary studies were included for depressive symptoms, major depression, and their effect on medication non-adherence, respectively. Globally, the average depressive symptoms prevalence using the random effect model was 34.17% (24.97, 43.37). In addition, the average prevalence of major depressive disorder was obtained to be 13.42% (10.53, 16.31). All of the 6 included systematic review studies reported a negative association between depressive symptoms and antiretroviral medication non-adherence. The pooled odds ratio of antiretroviral medication adherence among patients with depressive symptoms was 0.54 (0.36, 0.72) (I2 = 0.0%, p = 0.487).ConclusionGlobally, the prevalence of depressive symptoms and major depression is high. There existed a high degree of association between depressive symptoms and antiretroviral medication non-adherence. So, focused intervention modalities should be developed and implemented.
Possible Effects of Bright Light Therapy on Electroencephalogram-Vigilance in the Treatment of Depression in Adolescents: A Pilot Study
Authors: Berger Christoph , Dück Alexander , Gest Stephanie , Jonas Lena , Kölch Michael , Martin Franziska , Reis Olaf , Schroth Jennifer , Legenbauer Tanja , Holtmann Martin 
Published: May 2022

BackgroundChronotherapeutic treatments for depression, such as bright light therapy (BLT), are non-invasive and produce almost no side effects. However, study evidence for reliable neurobiological changes associated with treatment response is still rare. Several studies using EEG-vigilance indicate higher arousal and a later decline during resting state in adult depressive patients compared to healthy controls. To our knowledge, there are no study reports on EEG-vigilance in depressive youth to date.MethodsA total of 11 adolescents with depression receiving BLT were compared to 11 age and gender-matched patients with depression receiving treatment as usual (TAU). The BLT was administered in the morning for 2 weeks on five consecutive days per week. The depressive symptomatology was assessed using the Beck Depression Inventory (BDI-II) and the resting state electroencephalogram (EEG) of 20 min was recorded. EEG and BDI-II were assessed before and after 10 days of treatment. Vigilance level and vigilance decline were estimated using the VIGALL toolbox.ResultsBrain arousal increased after 10 days of bright light therapy in adolescents with depression. Severe depressive symptoms were associated with higher brain arousal levels; the BDI-II sum score correlated negatively with the amount of drowsiness.LimitationsThe sample size was small and participants’ brain arousal at baseline was not matched and differed between BLT and TAU groups.ConclusionThe BLT might have an additional effect on brain arousal. EEG-vigilance seems to be a reliable and valid marker for neurobiological changes that are probably associated with depression and its treatment and, therefore, might be of clinical relevance.
Longitudinal Development of Reasons for Living and Dying With Suicide Attempters: A 2-Year Follow-Up Study
Authors: Gysin-Maillart Anja C. , Jansen Rahel , Walther Sebastian , Jobes David A. , Brodbeck Jeannette , Marmet Simon 
Published: May 2022

BackgroundClinical interventions for patients after a suicide attempt might include a focus on Reasons for Living (RFL) and/or Reasons for Dying (RFD). The present study examined the longitudinal development of RFL and RFD in patients with and without a suicide-specific intervention - the Attempted Suicide Short Intervention Program (ASSIP).MethodsIn this secondary analysis of a 2-year follow-up randomized controlled study, participants completed the Suicide Status Form II to assess RFL and RFD, at baseline, as well as at 6-, 12-, 18-, and 24-months follow-up. Growth models and latent class analysis were used to investigate longitudinal developments in RFL and RFD. Regression models were used to test the association between RFL, RFD and suicidal reattempts and ideation.ResultsCross-sectionally and longitudinally, RFD, but not RFL, were associated with suicide reattempts and suicidal ideation. The number of RFD decreased significantly across the 24 month period (from 1.90 at t1 to 1.04 at t5 in the control group and from 2.32 at t1 to 0.51 at t5 in the intervention group), and this decrease was stronger (b = −0.02; p = 0.004) in the ASSIP group than in the control group. There was no overall change in RFL. Three latent trajectories of RFD were identified: a decreasing (n= 77), a steady high (n= 17) and a trajectory with first increasing and then decreasing RFD (n= 26). The proportion of patients in the ASSIP intervention was highest in the decreasing trajectory and lowest in the steady high trajectory. Patients in the steady high trajectory were characterized by worse mental health and fewer social obligations (partner, children) at baseline.ConclusionThe results confirm the importance of RFD within the suicidal process and show that the number of RFD can be further reduced over the period of 24 months with short interventions such as ASSIP. The relevance of number of RFL in the suicidal process, as protective factor, was not confirmed. In the subgroup of patients whose RFD did not decrease over a long period of time, there is a particularly high risk of suicidal ideation/behavior. Clinical interventions should focus more closely on RFD, their etiology and maintenance.
Prevalence and Outcomes of Pancreatic Enzymes Elevation in Patients With COVID-19: A Meta-Analysis and Systematic Review
Authors: Zhou You , Ge Yu-Tong , Yang Xiao-Xi , Cai Qian , Ding Yan-Bing , Hu Liang-Hao , Lu Guo-Tao 
Published: May 2022

Background:Although coronavirus disease 2019 (COVID-19) is considered to be a disease that mainly involves the respiratory system, an increasing number of studies have reported that COVID-19 patients had pancreatic enzymes (PE) elevation and even pancreatic injury. The study aims to determine the prevalence of PE elevation, and the relationship between elevated PE and prognosis in COVID-19 patients.MethodsA comprehensive literature search was conducted according to the PRISMA guideline in PubMed, Embase, Scopus, Web of Science, and Google Scholar for studies reporting PE elevation in patients with COVID-19 from 1st January 2020 to 24th November 2021.ResultsA total of 13 studies (24,353 participants) were included in our review. The pooled prevalence of PE elevation in COVID-19 patients was 24% (18%–31%), the pooled odds ratio (OR) of mortality was 2.5 (1.7–3.6), the pooled OR of ICU admission was 4.4 (2.8–6.8), and the pooled OR of kidney injury, respiratory failure and liver injury were 3.5 (1.6–7.4), 2.0 (0.5–8.7), and 2.3 (1.4–3.9) respectively. In addition, the subgroup analysis revealed that although PE elevated to &gt; 3 × upper normal limit (ULN) was significantly related to the mortality (OR = 4.4, 2.1–9.4), it seemed that mild elevation of PE to 1–3 ULN also had a considerable risk of mortality (OR = 2.3, 1.5–3.5).ConclusionsPE elevation was a common phenomenon in patients with COVID-19, and was associated with poor clinical outcomes. However, due to the limited numbers of included studies, the result of our study still needed to be validated.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=295630, identifier: CRD42021295630.
COVID-19 Vaccine Hesitancy Among Older Adolescents and Young Adults: A National Cross-Sectional Study in China
Authors: Zhang Panpan , Li Yan , Wang Huanchun , Luo Liyan , Wang Ping , Wang Huimin , Li Qing , Meng Zejing , Yang Hui , Liu Yuanhong , Zhou Shiyue , Li Nan , Zhang Shengnan , Bi Jianzhong , Zhang Jiewen , Zheng Xiaolei 
Published: May 2022

BackgroundWith promotion of COVID-19 vaccinations, there has been a corresponding vaccine hesitancy, of which older adolescents and young adults represent groups of particular concern. In this report, we investigated the prevalence and reasons for vaccine hesitancy, as well as potential risk factors, within older adolescents and young adults in China.MethodsTo assess these issues, an online survey was administered over the period from March 14 to April 15, 2021. Older adolescents (16–17 years old) and young adults (18–21 years old) were recruited nationwide from Wechat groups and results from a total of 2,414 respondents were analyzed. Socio-demographic variables, vaccine hesitancy, psychological distress, abnormal illness behavior, global well-being and social support were analyzed in this report.ResultsCompared to young adults (n = 1,405), older adolescents (n = 1,009) showed higher prevalence rates of COVID-19 vaccine hesitancy (16.5 vs. 7.9%, p &lt; 0.001). History of physical diseases (p = 0.007) and abnormal illness behavior (p = 0.001) were risk factors for vaccine hesitancy among older adolescents, while only a good self-reported health status (p = 0.048) was a risk factor for young adults. Concerns over COVID-19 vaccine side effects (67.1%) and beliefs of invulnerability regarding infection risk (41.9%) were the most prevalent reasons for vaccine hesitancy. Providing evidence on the vaccine reduction of COVID-19 infection risk (67.5%), ensuring vaccine safety (56.7%) and the low risk of side effects (52.7%) were the most effective persuasions for promoting vaccinations.ConclusionIn China, older adolescents showed a higher prevalence for vaccine hesitancy than that of young adults. Abnormal illness behavior and history of physical diseases were risk factors for vaccine hesitancy among these older adolescents, while social support represents an important factor which could help to alleviate this hesitancy.
Changes in the Plasma and Platelet Nitric Oxide Biotransformation Metabolites during Ischemic Stroke—A Dynamic Human LC/MS Metabolomic Study
Authors: Bladowski Maciej , Szahidewicz-Krupska Ewa , Wiśniewski Jerzy , Fortuna Paulina , Chojdak-Łukasiewicz Justyna , Budrewicz Slawomir , Fleszar Mariusz , Doroszko Adrian 
Published: May 2022

Despite improvement in the management of modifiable cardiovascular risk factors, ischemic stroke remains the leading cause of morbidity and mortality in the adult population. The aim of this study was to analyze the time-dependent dynamic differences in expression of the nitric oxide (NO) metabolic pathway in the platelet and plasma compartment between subjects with and without ischemic stroke. Additionally, the interplay between these parameters and platelet aggregation was investigated. A total of 418 patients in acute phase of non-cardioembolic stroke were investigated. Following the inclusion and exclusion criteria, finally 40 subjects with stroke and 39 demographically matched healthy participants were enrolled. Neurological physical examination, followed by assessment of the platelet and plasma levels of the nitric oxide synthase (NOS) inhibitors, including asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), as well as NOS substrate-L-Arginine were performed dynamically three times within the first 24-h, then on the 3rd and 7th day after the stroke onset, which was compared with the healthy control. The platelet L-Arginine concentration was significantly higher on the 1st and 3rd day of stroke, while the plasma levels were significantly lower on exact days in comparison to the control. The competitive NOS-inhibitors in platelets were stably elevated in stroke subjects, whereas no significant differences in plasma compartment were noted. The arachidonic-acid-induced platelet aggregation was negatively associated with the platelet NOS substrate bioavailability, as assessed by the L−Arginine ADMA-ratio on the 3rd and 7th day. Subjects with non-cardioembolic ischemic stroke are characterized by elevated platelet levels of NOS inhibitors. Management of stroke results in increasing the platelet L-Arginine concentration and subsequent NO bioavailability in the platelet compartment.
Studi Penetapan Wali Adhal Terkait Pernikahan Tidak Sekufu Dalam Penetapan Pengadilan Agama Jepara Nomor 15/Pdt.P/2019/PA.Jepr Menurut Madzhab Syafi’i
Authors: Alviani Tiyas 
Published: May 2022

Keberadaan kafaah dalam pernikahan diyakini sebagai faktor yang dapat menghilangkan dan menghindarkan aib dalam keluarga. Menurut Madzhab Syafi’i dalam penetapan Nomor 15/Pdt.P/2019/PA.Jepr keharusan adanya wali dalam pernikahan baik gadis ataupun janda. Jika wali nasab masih enggan untuk menikahkan anaknya dengan alasan hanya melihat calon menantunya berkelakuan kurang baik dan pendidikannya tidak seimbang, tentu alasan yang demikian tidak dapat dibenarkan. Maka perwalian akan berpindah kepada penguasa atau Qadli dan tidak berpindah kepada wali yang jauh. Karena penolakan yang demikian, maka wali keluar dari keadaannya sebagai wali dan wali tersebut menjadi orang yang zalim. Berdasarkan hasil penelitian yang dilakukan dapat disimpulkan bahwa dalam penetapan tersebut alasan yang digunakan oleh wali hanya beralasan calon menantunya berkelakuan kurang baik dan pendidikannya tidak seimbang dengan anaknya. sehingga alasan tersebut tidak syar’i dan tidak berdasarkan Hukum Islam. Sehingga jika wali nasab yang adhal dengan alasan yang tidak syar’i atau sebab yang tidak ada dasarnya dalam hukum Islam, maka perkawinan calon mempelai perempuan dengan calon suaminya yang menggunakan wali Hakim sebagai pengganti wali adhal adalah hukumnya sah.
Proposição de um simulador para uma válvula reguladora de pressão em um sistema preventivo de blowout / Proposal of a simulator for a pressure regulating valve in a blowout preventer system
Authors: Pinto Igor de Souza , Da Silva Mariana Santos , Assayag Gustavo Trindade , Chaves Luiz Antônio de Oliveira , Delesposte Jamile Eleutério , Tammela Iara , Cardoso Rodolfo , Colombo Danilo 
Published: May 2022

O blowout preventer (bop) é uma barreira fundamental na segurança das operações de perfuração e completação de poços que requer a disponibilidade e a confiabilidade como fatores que devem ser gerenciados com eficiência. Entretanto, estudos demonstram que o equipamento ainda apresenta um elevado índice de falhas e tempo de indisponibilidade, sendo a válvula reguladora de pressão um dos principais componentes responsáveis por este problema. Sendo assim, o objetivo da pesquisa é desenvolver uma modelagem matemática para construção de um simulador da dinâmica da reguladora, a fim de dar suporte à implementação de estudos de manutenção baseada em condição (cbm). Seis principais etapas foram adotadas com o intuito de alcançar o objetivo do trabalho. Análise de mecanismos da física de funcionamento do componente e a identificação de parâmetros operacionais na literatura foram necessárias, bem como a modelagem e simulação computacional desenvolvida no software simulink/matlab. Os resultados alcançados nessa etapa de projeto foram aderentes à literatura, representado pelos perfis de curva de carga de pressão, velocidade e deslocamento do mecanismo de controle de fluxo. As avaliações demonstram potencial uso para auxiliar futuras análises de cenários de falhas e obter informações para implementar cbm em componentes hidráulicos do conjunto bop.
“Jogar para não gerar”: o desafio de um minicurso online / "Play not to generate": the challenge of an online minicourse
Authors: Castione Regiane Cristina Mareze Sipioni , Bezerra Renata Camacho , Pereira Eliane Nascimento 
Published: May 2022

Após a lei 12.305/2010 entrar em vigor, os estados e municípios passaram a ter um direcionamento e foi estabelecido metas, princípios e instrumentos com o objetivo de se buscar soluções para promover o fim dos “lixões” e realizar a gestão dos resíduos sólidos. O Plano de Gerenciamento de Resíduos Sólidos (PGRS) é um documento que descreve as ações que são realizadas em um estabelecimento para segregação, coleta, armazenamento, transporte, destinação, reciclagem e disposição final dos resíduos sólidos, bem como, descreve a forma como deve ser realizada a educação ambiental para sensibilização e incentivo dos membros da comunidade a desenvolverem atividades que contribuam com o meio ambiente e promovam a redução na fonte, dos resíduos sólidos. Numa escola pública discutir e implantar o PGRS é algo desafiador, pois há rotatividade de alunos e professores e ainda, nem sempre é possível ter um responsável técnico a disposição. Diante disso, surge o seguinte questionamento: Qual a melhor estratégia para operacionalizarmos o PGRS e sensibilizar a comunidade escolar no cumprimento a legislação? Com o objetivo de responder a este questionamento, realizamos um minicurso gameficado e a partir das análises iniciais foi possível perceber que os alunos se sentiram motivados com a estratégia utilizada, bem como, disseram ter adquirido novos conhecimentos a respeito do assunto. Além disso, foi possível constatar que o grupo ficou sensibilizado em melhorar sua prática na separação e reciclagem de resíduos sólidos.