bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Social Workers in Cirrhosis Care: a Systematic Review
Authors: Ufere Nneka N. , Hinson Jan , Finnigan Simon , Powell Elizabeth E. , Donlan John , Martin Cathy , Clark Phil , Valery Patricia C. 
Published: April 2022

Abstract
Purpose of review
To report social workers’ involvement in supporting patients with cirrhosis.

Recent findings
Six intervention studies (three published in the past 3 years) highlighed the potential role of social worker-led interventions to improve the outcomes of patients with cirrhosis. In studies of patients with alcohol-related liver disease (n = 4), social workers conducted psychosocial assessments, screened for substance use disorder and psychological distress, coordinated referrals to addiction services, and provided relapse prevention therapy. In studies including transplant recipients or candidates (n = 2), social workers focused on psychosocial interventions. In two studies (n = 1 patient with alcohol-related liver disease; n = 1 transplant recipients), social workers provided practical support (e.g., housing, transportation). Most articles provided limited information about the intervention and the role of the social worker, making comparisons of the studies difficult.

Summary
More high-quality evidence is needed to formally assess the impact of social workers in improving the outcomes of patients with cirrhosis.
Gorenstein points in $${\mathbb {P}}^{3}$$ via Hadamard products of projective varieties
Authors: Bocci C. , Capresi C. , Carrucoli D. 
Published: April 2022

AbstractWe show how to construct a stick figure of lines in $${\mathbb {P}}^3$$

P

3

using the Hadamard product of projective varieties. Then, applying the results of Migliore and Nagel, we use such a stick figure to build a Gorenstein set of points with given $$h-$$

h
-

vector $${\varvec{h}}$$

h

. Since the Hadamard product is a coordinate-wise product, we show, at the end, how the coordinates of the points, in the Gorenstein set, can be directly determined.
Fit and Proper Requirements in the EU Banking Sector. A Step Further
Authors: Arrigoni Matteo , Rivolti Mattia 
Published: April 2022

AbstractPrudential regulation has become increasingly important over time. In such a context, strict suitability requirements for members of the management body and key function holders are considered an adequate tool to safeguard the sound and prudent management of banks. In the years following the Great Financial Crisis in 2008–2009 and the Eurozone sovereign debt crisis in 2010–2012, the regulatory and supervisory approach to banks’ corporate governance has seen a significant evolution. The centralisation of banking supervision at the Eurozone level was complemented by the application of a single rulebook throughout the European Union which stated, in compliance with the Capital Requirements Directive, higher suitability requirements for being appointed as a member of a management body or as a key function holder at a bank. Furthermore, the choice to identify fit and proper requirements through standards attributes significant power to the decision maker, thus allowing greater public control over private choices, and is justified by the need to prevent negative externalities. This approach is open to debate. Against the background of the pursuit of public interest, the lawmaker confers discretionary power on the supervisory authorities (the European Central Bank and the national competent authorities), and sets restrictions on the job market for board member candidates. This paper is a contribution enriching the ongoing discussion about the existing regulatory and policy regime, with a special focus on the specific functions performed by the management body members and particularly by the chairs of the management body’s special committees.
Firms and climate change: a review of carbon risk in corporate finance
Authors: Wang Yao , Wu Zhenshu , Zhang Guangxiao 
Published: April 2022

AbstractThis paper provides an overview of financial economics-based research on carbon risk with an emphasis on corporate finance. In the corporate finance literature, carbon risk refers to the impact of society’s transition to a low-carbon economy on firm value due to tightening regulations, changing consumer preferences, reputational damage, etc. We focus on the links between carbon risk and different firm performance factors, such as firm risk, cost of capital, financial performance, firm value, and corporate decisions. Although research on carbon risk is still emerging in the corporate finance field, the amount of literature on this topic has been increasing, especially in the last 2 years. We find that some results are robust, while others are mixed. This indicates that conflicting hypotheses still exist, leading to a need for more in-depth exploration.
Dynamic Ad Network Ordering Method Using Reinforcement Learning
Authors: Afshar Reza Refaei , Zhang Yingqian , Kaymak Uzay 
Published: April 2022

AbstractReal time bidding is one of the most popular ways of selling impressions in online advertising, where online ad publishers allocate some blocks in their websites to sell in online auctions. In real time bidding, ad networks connect publishers and advertisers. There are many available ad networks for publishers to choose from. A possible approach for selecting ad networks and sending ad requests is called Waterfall Strategy, in which ad networks are selected sequentially. The ordering of the ad networks is very important for publishers, and finding the ordering that will provide maximum revenue is a hard problem due to the highly dynamic environment. In this paper, we propose a dynamic ad network ordering method to find the best ordering of ad networks for publishers that opt for Waterfall Strategy to select ad networks. This method consists of two steps. The first step is a prediction model that is trained on real time bidding historical data and provides an estimation of revenue for each impression. These estimations are used as initial values for the Q-table in the second step. The second step is based on Reinforcement Learning and improves the output of the prediction model. By calculating the revenue of our method and comparing that with the revenue of a fixed and predefined ordering method, we show that our proposed dynamic ad network ordering method increases publishers’ revenue.
508 Comparing effectiveness and safety of levetiracetam loading doses among patients with status epilepticus.
Authors: De Los Santos Bertha , Barnes Brian J , Cohen Rose , Mangat Halinder 
Published: April 2022

OBJECTIVES/GOALS: Our long-term goal is to improve the clinical outcomes of patients with status epilepticus through increasing the level of evidence surrounding guidelines. The specific objective of our proposed work is to compare the outcomes and adverse drug events between the Neurocritical Care and American Epilepsy Society levetiracetam dose recommendations. METHODS/STUDY POPULATION: This is a retrospective, single site, cohort study comparing outcomes of hospitalized patients with status epilepticus treated with levetiracetam bolus at the University of Kansas Health System. Patients outcomes will be compared based on levetiracetam bolus dose received. The primary outcome will be seizure reoccurrence within 24 hours. Secondary outcomes include number of additional anti-epileptic drugs administered, cumulative dose of benzodiazepines administered within 24 hours of levetiracetam bolus administration and incidence of adverse drug reactions. All study data will be extracted retrospectively from the EPIC chart review following patient list generation through the HERON i2b2 database query. RESULTS/ANTICIPATED RESULTS: Aim 1 will characterize levetiracetam dosing among patients admitted to the University of Kansas Medical Center for status epilepticus during routine clinical care. We hypothesize that given the inconsistency in dosing recommendations from various professional societies and drug references, we will observe inconsistent dosing of levetiracetam among those hospitalized due to status epilepticus.Aim 2 will evaluate effectiveness and safety across the various levetiracetam doses. We estimate that adherence to the higher weight-based dosing recommendations of the 2016 American Epilepsy Society guideline may result in improved outcomes with a similar frequency and severity of adverse drug events compared to lower/fixed-dose levetiracetam dose recommendation of the 2012 Neurocritical Care guideline. DISCUSSION/SIGNIFICANCE: Notable inconsistencies across the dosing recommendations for levetiracetam exist between the guidelines for treatment of status epilepticus and commonly used tertiary drug information databases. This variation in guidance may lead to differences in dosing and warrants further exploration to better support the management of status epilepticus.
Hibiscus (Hibiscus sabdariffaL.) supplementation increases butyrate synthesis and reduces inflammatory cells, attenuating the formation of aberrant crypt foci in BALB/c mice induced to pre-neoplastic lesions
Authors: Bernardes Andressa Ladeira , Moraes Luís Fernando de Sousa , Cruz Bruna Cristina dos Santos , da Conceição Lisiane Lopes , de Oliveira Leandro Licursi , Sarandy Mariaurea Matias , Gonçalves Reggiani Vilela , Peluzio Maria do Carmo Gouveia 
Published: April 2022

AbstractThe development of colorectal cancer involves some morphological changes, and in the initial stage, pre-neoplastic lesions called aberrant crypt foci (ACF) appear. Thus, an intervention with sources of bioactive compounds such asHibiscus sabdariffaL., rich in phenolic compounds and anthocyanins, could attenuate the risk of developing these lesions due to its antioxidant, anti-inflammatory and anti-proliferative properties. Therefore, the aim of this study was to evaluate the effects of 5 % and 10 % supplementation of dehydratedH. sabdariffacalyces (DHSC) during the development of 1,2-dimethylhydrazine-induced pre-neoplastic lesions in male BALB/c mice. The characterisation of DHSC was carried out. Thein vivoexperiment lasted 12 weeks, and the animals were randomly divided into three experimental groups: the control group (CON) and the supplemented groups with 5 % DHSC and 10 % DHSC. The activities of liver enzymes catalase (CAT) and superoxide dismutase were determined. In addition, ACF, SCFA, presence of inflammatory infiltrates, goblet cells and leucocytes in the colonic mucosa were quantified. There was a significant reduction in ACF and the presence of inflammatory infiltrates in the colon of animals in groups 5DHSC and 10DHSC. In addition, the 10DHSC group showed an increase in the activity of the CAT enzyme, in the production of butyrate and in the presence of natural killer cells in the colon, in addition to more hypertrophied goblet cells. Based on these findings, it is suggested that DHSC supplementation may be recommended to attenuate cellular responses in the early stage of pre-neoplastic lesions.
The Rise of Swedish Social Democracy
Authors: Boix Carles , Magyar Zsuzsanna 
Published: April 2022

AbstractWe examine the rise and mobilizational dynamics of social democracy, employing data reported by the Swedish authorities on the distribution of voting eligibility, turnout and partisan vote in local elections during the 1910s at a high level of disaggregation (by narrow income segments and administrative units). In line with the existing literature, we show that electoral socialism depended on both the extension of the suffrage to its ‘natural’ electorate, that is, the urban working class, and the organizational capacity of trade unions and other civic associations. In addition, we show that socialist support was not uniform within the working class – even for a highly homogeneous society. Instead, the social-democratic vote was initially stronger among low- to middle-income workers, only expanding to poor voters later in time. We complement our local data with an interwar panel analysis of socialist vote and post-war survey data.
Africa and the Domestic Implementation of the Geneva Conventions and Additional Protocols: Problems and Solutions
Authors: Balarabe Kasim 
Published: April 2022

AbstractThe Geneva Conventions have achieved universal ratification, and Additional Protocols I and II are binding on all African states except Eritrea and Somalia; however, their observance in African conflicts is flawed and inconsistent. From deliberate attacks on civilian populations to abduction and hostage-taking, humanitarian rules are openly flouted. Through an extensive assessment of the domestic measures required to implement the Geneva Conventions and Protocols in Africa, this article identifies the current level of implementation, existing gaps and possible non-legal factors that impact respect for the instruments in African conflicts. Violations are often associated with historical, political, religious and social factors that tainted the instruments’ lofty provisions and bequeathed a legacy that challenges the obligation to respect. Additionally, continuous political and religious struggles and the search for identity and relevance have displaced the ideals of the instruments’ humanitarian provisions. Reversing this trend requires an approach that appeals to and engages the continent beyond the traditional argument of obligation to respect.
Effectiveness of screened ceilings over the current best practice in reducing malaria prevalence in western Kenya: a cluster randomized-controlled trial
Authors: Minakawa Noboru , Kawada Hitoshi , Kongere James O. , Sonye George O. , Lutiali Peter A. , Awuor Beatrice , Isozumi Rie , Futami Kyoko 
Published: April 2022

AbstractIncreases in bed net coverage and antimalarial treatment have reduced the risk of malaria in sub-Saharan Africa. However, the pace of reduction has slowed, and new tools are needed to reverse this trend. We evaluated houses screened with insecticide-treated ceiling nets using a cluster randomized-controlled trial in western Kenya. The primary endpoints were Plasmodium falciparum PCR-positive prevalence (PCRPfPR) of children from 7 months to 10 years old and anopheline density. Ceiling nets and bed nets were provided to 1073 houses, and 1162 houses were provided with bed nets only. The treatment and control arms each had four clusters. We conducted three epidemiological and entomological post-intervention surveys over the course of a year and a half. Each epidemiological survey targeted 150 children per cluster, and entomological surveys targeted 25 houses. When the three surveys were combined, the median PCRPfPRs were 23% (IQR 8%) in the intervention arm and 42% (IQR 12%) in the control arm. The adjusted risk ratio (RR) was 0.53 [95% confidence interval (CI) 0.41–0.71; P = 0.029]. The median anopheline densities were 0.4 (IQR 0.4) and 2.0 (IQR 1.4), respectively. The adjusted RR was 0.41 (95% CI 0.29–0.90; P = 0.029). The present study indicates additional protection from insecticide-screened ceilings over the current best practice.
Respiratory viral infections are prevalent but uncomplicated in single ventricle CHD
Authors: Calley Brandon J. , Zhang Liyun , Pan Amy Y. , Ginde Salil , Kindel Steven J. , Spearman Andrew D. 
Published: April 2022

AbstractBackground:Patients with single ventricle CHD have significant morbidity and healthcare utilisation throughout their lifetime, including non-cardiac hospital admissions. Respiratory viral infections are the main cause of hospitalisation in children, but few data exist for single ventricle patients. We sought to identify how respiratory viral infections impact patients with single ventricle CHD and potential differences between Glenn and Fontan circulation.Methods:We conducted a retrospective study of patients seen from 01/01/2011–12/31/2020. We identified patients with a history of single ventricle CHD and Glenn palliation, and a normoxic control group with isolated atrial septal defect requiring surgical closure. We compared viral-related clinical presentations, admissions, and admission characteristics.Results:A total of 312 patients were included (182 single ventricle, 130 atrial septal defect). Single ventricle patients were more likely than children with isolated atrial septal defect to be admitted with a respiratory virus (odds ratio 4.15 [2.30–7.46]), but there was no difference in mechanical ventilation or hospital length of stay (p = 0.4709). Single ventricle patients with Glenn circulation were more likely than those with Fontan circulation to present and be admitted (odds ratio 3.25 [1.62–6.52]), but there was no difference in ICU admission, mechanical ventilation, or hospital length of stay (p = 0.1516).Conclusions:Respiratory viral infections are prevalent but uncomplicated in patients with single ventricle CHD. Viral-related presentations and admissions are more prevalent during the period of Glenn circulation compared to Fontan circulation; however, rate of mechanical ventilation and hospital length of stay are similar.
Morphometric Analysis of Lysosomes in the Renal Tubule in Monoclonal Gammopathy Using Transmission Electron Microscopy: “Mottled Appearance” and Beyond
Authors: Jung Minsun , Lee Hajeong , Moon Kyung Chul 
Published: April 2022

AbstractLysosomal “mottled appearance”, or uneven electron-dense content related to monoclonal gammopathy (MG), has been mainly described in light chain proximal tubulopathy (LCPT). We aimed to determine the ultrastructural characteristics of lysosomal mottled appearance in kidney biopsies and its association with LCPT and MG. Seventy-seven biopsies were grouped into LCPT (n = 5), MG conditions other than LCPT (n = 43), and non-MG conditions (n = 29). The mottled lysosomes in the renal tubules were evaluated using transmission electron microscopy and morphometric analysis. Mottled lysosomes were more prevalent (% of present cases) and frequent (no. of mottled lysosomes/20,000× ultramicroscopic field) in the LCPT group (100% and 8.20 ± 4.15/field) than in the MG (41.9% and 1.13 ± 2.05/field) and non-MG (37.9% and 0.80 ± 1.44/field) groups. In morphometric analysis of all mottled lysosomes (n = 520) detected from the 34 biopsies (5 LCPT, 18 MG, and 11 non-MG), we found that mottled lysosomes were larger, more irregular, and more electron-dense for the LCPT group than for the MG and non-MG groups. Therefore, mottled lysosomes can be present in disorders other than LCPT or even without MG. The morphological characteristics of mottled lysosomes could provide objective guidance for the diagnosis of LCPT.
Solar Flux Dependence of Post‐Sunset Enhancement in Vertical Total Electron Content Over the Crest Region of Equatorial Ionization Anomaly
Authors: Kumar A. , Chakrabarty D. , Pandey K. , Yadav A. K. 
Published: April 2022

AbstractBased on 10 years' of vertical total electron content (VTEC) data in solar cycle 24 from Ahmedabad (23.0°N, 72.6°E, dip angle 35.2°), a station under the crest region of equatorial ionization anomaly (EIA), it is shown that both the integrated residual and total post‐sunset enhancements in VTEC are conspicuous during Equinox and December solstice when solar flux level exceeds 110 solar flux unit (sfu) with the exception of the year 2012–2013. The post‐sunset enhancements are absent in June solstice at this local time even if the solar flux level exceeds 110 sfu. The integrated residual and total VTEC enhancements during post‐sunset hours are found to be linearly correlated with the solar flux level in Equinox and December solstice. It is noted that a parabolic fit works better for the integrated total VTEC enhancement during December solstice suggesting a possible saturation of VTEC enhancements at high solar flux levels. Based on these observations and Thermosphere Ionosphere Electrodynamics‐General circulation model (TIE‐GCM) outputs, it is argued that the pre‐reversal enhancement (PRE) in the equatorial F region zonal electric field works in tandem with latitudinal gradient in the F region plasma density to determine the degree of VTEC enhancement over the EIA crest region during post‐sunset hours. These results highlight the solar flux dependence of the post‐sunset enhancement of VTEC over the crest region and show that sudden stratospheric warming events in 2012–2013 suppressed these enhancements in December solstice even if solar flux levels exceeded 110 sfu.
MFG-E8 alleviates intervertebral disc degeneration by suppressing pyroptosis and extracellular matrix degradation in nucleus pulposus cells via Nrf2/TXNIP/NLRP3 axis
Authors: Ma Haiwei , Xie Chenglong , Chen Zhengtai , He Gaolu , Dai Zihan , Cai Hanchen , Zhang Haojie , Lu Hongwei , Wu Hongqiang , Hu Xinli , Zhou Kailiang , Zheng Gang , Xu Huazi , Xu Cong 
Published: April 2022

AbstractIntervertebral disc degeneration (IVDD) is a chronic age-related degenerative disease accompanied by complex pathophysiological mechanisms. Increasing evidence indicates that NLRP3 inflammasome mediated pyroptosis of nucleus pulposus (NP) cells displays an important role in the pathological progression of IVDD. Milk fat globule-EGF factor-8 (MFG-E8) is an endogenously secreted glycoprotein with beneficial effects of anti-inflammatory, antioxidant, and modulation of NLRP3 inflammasome. However, the effect of MFG-E8 on IVDD remains unclear. In this study, our purpose is to clarify the expression changes of MFG-E8 in the IVDD process and explore the role and mechanism of MFG-E8. We found that MFG-E8’s expression was reduced in degraded nucleus pulposus tissues of humans and rats as well as hydrogen peroxide (H2O2)-treated NP cells. Exogenous supplementation of MFG-E8 could rescue H2O2-induced oxidative stress, mitochondrial dysfunction, and NLRP3 inflammasome activation and protect NP cells from pyroptosis and extracellular matrix (ECM) degradation. Mechanistically, Nrf2/TXNIP/NLRP3 axis plays a crucial role in MFG-E8-mediated suppression of the above-pathological events. In vivo, we established a rat intervertebral disc acupuncture model and found that MFG-E8 administration effectively alleviated IVDD development by imageological and histomorphological evaluation. Overall, our findings revealed the internal mechanisms underlying MFG-E8 regulation in NP cells and its intrinsic value for IVDD therapy.
Cell-in-cell structure mediates in-cell killing suppressed by CD44
Authors: Su Yan , Huang Hongyan , Luo Tianzhi , Zheng You , Fan Jie , Ren He , Tang Meng , Niu Zubiao , Wang Chenxi , Wang Yuqi , Zhang Zhengrong , Liang Jianqing , Ruan Banzhan , Gao Lihua , Chen Zhaolie , Melino Gerry , Wang Xiaoning , Sun Qiang 
Published: April 2022

AbstractPenetration of immune cells into tumor cells was believed to be immune-suppressive via cell-in-cell (CIC) mediated death of the internalized immune cells. We unexpectedly found that CIC formation largely led to the death of the host tumor cells, but not the internalized immune cells, manifesting typical features of death executed by NK cells; we named this “in-cell killing” which displays the efficacy superior to the canonical way of “kiss-killing” from outside. By profiling isogenic cells, CD44 on tumor cells was identified as a negative regulator of “in-cell killing” via inhibiting CIC formation. CD44 functions to antagonize NK cell internalization by reducing N-cadherin-mediated intercellular adhesion and by enhancing Rho GTPase-regulated cellular stiffness as well. Remarkably, antibody-mediated blockade of CD44 signaling potentiated the suppressive effects of NK cells on tumor growth associated with increased heterotypic CIC formation. Together, we identified CIC-mediated “in-cell killing” as a promising strategy for cancer immunotherapy.