bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uterine miR-877-3p and let-7a-5p are increased during simulated menstruation in a mouse model
Authors: Watters Marianne , Walker Catherine A , Murray Alison A , Nicol Moira , Maybin Jacqueline A 
Published: February 2022

Lay summary
Heavy periods are common and debilitating, but we do not fully understand how they are caused. Increased understanding of menstrual bleeding could result in new treatments for problematic periods. Low oxygen levels are present in the womb lining during a period. These low oxygen levels help trigger the repair process required to stop menstrual bleeding. MicroRNAs (miRNAs) are small molecules that can affect cell function, and some are regulated by oxygen levels. We examined whether such miRNAs were present in the womb lining during a period. To overcome the variability present in humans, we studied the womb of mice given hormones to mimic the human menstrual cycle. We revealed that two miRNAs known to be regulated by oxygen levels were increased in the womb during menstruation. These miRNAs may help regulate menstrual blood loss and merit further study as a potential target for future treatments for heavy periods.
Вплив одновісної деформації на заповнення рівня, пов’язаного з А-центром, у кристалах n-Si
Authors: Федосов А.В. , Луньов С.В. , Федосов С.А. 
Published: February 2022

Досліджено монокристали $n$-Si з вихідною концентрацією носіїв струму 1,24 · 1014 см–3, опромінені γ-квантами Co60 дозою 3,8 · 1017 кв/см2. Досліджено п'єзоопір γ-опромінених кристалів n-Si за умови, коли X ║ J ║ [100] та X ║ J ║ [110]. Представлено метод розрахунку швидкості зміщення і оцінено ступінь заповнення α глибоких рівнів. Обчисленовеличину зміни енергетичної щілини між глибоким енергетичним рівнем EC – 0,17 еВ і нижніми долинами зони провідності n-Si при одновісній пружній деформації вздовж кристалографічних напрямків [100] і [110]. Визначено середнє значення коефіцієнта α (ступінь заповнення глибоких енергетичних рівнів) для різних температур.
Dakwah Patterns and Communication of Student Character Program at Al-Fityan Kubu Raya
Authors: Gitosaroso Muh. , Hefni Harjani 
Published: February 2022

This study aims to determine the pattern of da'wah and communication used by the Al-Fityan Kubu Raya Foundation in forming students' Akhlaq al-Karimah in established character education programs, both in schools and in dormitories. The research was conducted using a descriptive approach obtained through interviews, observation, and documentation. Based on the data obtained, the da'wah pattern carried out by the Al-Fityan Foundation was bi al-lisan (warnings, calls, appeals, and words), bi al-hal (through examples of behavior directly given by educators/mentors), and bi al-arkan (through the rules). Meanwhile, the communication pattern is face-to-face through various learning models, namely: Circular, straight back, and Letter U in the character education mentoring program.
Synthesis and evaluation of 6-Fluoro benzothiazole substituted quinazolinones
Authors: Niharika P. , Risy Namratha J , Sunitha N. , Manohar Babu S. 
Published: February 2022

The present work was hypothesized to synthesize Benzothiazole substituted diethyl amino Quinazolinone derivatives and evaluate their antimicrobial activity. Quinazolinones were synthesized from condensation of 2-amino benzothiazole, anthranilic acid and acetic anhydride further followed by condensation with formaldehyde and diethyl amine. Antimicrobial activity was evaluated by agar disc diffusion using organisms and anti-inflammatory and antioxidant activies were studied using albumin denaturation and hydrogen peroxide radical scavenging methods. The structures of the synthesized Quinazolinone derivatives were confirmed by spectral analysis, such as IR, H-NMR and among the derivatives screened, the compounds 4d, 4f 4g, 4h have appreciable antimicrobial activity compared to standards. The compounds (4a-4h) have least anti-inflammatory activity while compound 4g have significant antioxidant activity as that of positive control.
DEVIASI SOSIAL HUBUNGAN SESAMA JENIS HOMOSEKSUAL PERSPEKTIF PSIKOLOGI ISLAM
Authors: Eliya Fitri , Ladawiyah Putri Robiatul , Alfiah Alfiah 
Published: February 2022

The term social deviation or more commonly referred to as deviation of behavior is a pattern of behavior that for many people this social deviation is a bad deed and exceeds the limits of the norms of propriety that can be tolerated by humans. Sexual orientation between men or gay sex is an example of behavioral deviations that clearly violate the norms of propriety in society and certainly do not conform to the teachings of any religion. exual relations between men or gay sex is an example of behavioral deviations that clearly violate the norms of propriety in society and certainly do not conform to the teachings of any religion. Studied in the view of Islam this perversion of sexual desire is clearly opposed to the creation of man by Allah SWT who must be in accordance with his codrad. The writing method used in studying maslah in the writing of this article is "library reseuarch" or literature research. The result of this study, namely deviant behavior in the form of male relationships with the same or homosexual is as a form of opposition to the human codrad that has been created by Allah SWT. Man must have high achievement in terms of the control of his passions is a way to train himself to have a high codrad that begins with the formation of noble morals. The attempt to be able to merubag akhlaq is to conquer anger, greed, and lust "shahwat". It is also an effort and a struggle of patience to build a habit. The despicable nature according to Imam Al Ghazali is a form of bathniah that if the despicable nature is erased then the praiseworthy nature will replace it.
Rolnictwo ekologiczne jako zawód i powołanie. Studium tożsamości, organizacji i potencjału rozwojowego polskich rolników ekologicznych
Authors: Bielski Piotr 
Published: February 2022

Praca stanowi pierwsze w Polsce socjologiczne studium rozwoju rolnictwa ekologicznego, zakorzenione w paradygmacie interpretatywnym, oparte na metodologii teorii ugruntowanej. Podstawą badań było 27 wywiadów narracyjnych i swobodnych z rolnikami ekologicznymi z terenu całej Polski, obserwacja uczestnicząca na imprezach eko-rolników, analiza treści publikacji poświeconych eko-rolnictwu. Centralne pytanie dotyczy tego, co jest istotą rolnictwa ekologicznego? Czy mamy do czynienia z zawodem czy ruchem społecznym? Co odróżnia eko[1]rolnika od tzw. rolnika konwencjonalnego? Jak wygląda świat społeczny rolnictwa ekologicznego, jakie areny sporów w nim występują? Na początku lat 90 XX wieku w Polsce było ok 20 eko-gospodarstw, a praktykujący „ekologię” rolnicy uznawani byli często za nierozumianych idealistów. Kluczowym czynnikiem dynamizujacym rozwój eko-rolnictwa było wstąpienie Polski do Unii Europejskiej, w latach 2003-2005 nastąpił ponad 3-krotny wzrost liczby gospodarstw ekologicznych (z 2286 do 7813) i ponad 4-krotny wzrost powierzchni upraw ekologicznych. Od początku rozwoju ruchu o „ekologiczności” decydowali o tym sami rolnicy ekologiczni, a certyfikaty wystawiało założone przez nich stowarzyszenie „Ekoland”. W pierwszej dekadzie XXI wieku w związku z rozwojem unijnej i państwowej infrastruktury wsparcia, funkcje tę formalnie przejęły prywatne firmy będące agencjami certyfikującymi, lecz na granice prawne nakładają się wciąż nieformalne granice świadomościowe. W pracy wyróżniono trzy podstawowe typy eko-rolników. Eko-rolnicy z misją (pionierzy i adepci) postrzegają swą działalność jako rodzaj projektu etycznego („zdrowe społeczeństwo dzięki zdrowym roślinom i zwierzętom”), który jednocześnie jest dla nich źródłem utrzymania. Eko-rolnicy dotacyjni postrzegają tę działalność jako rodzaj biznesu, przyznając drugorzędne lub żadne znaczenie wartościom pozaekonomicznym. Eko-rolnicy kontemplacyjni uprawiają ze względu na autoteliczną wartość rolnictwa i harmonii z przyrodą, nie nastawiając się na czerpanie dochodu z płodów ziemi.
Mesenchymal Stem Cell Exosomes Promote Growth Plate Repair and Reduce Limb-Length Discrepancy in Young Rats
Authors: Wong Keng Lin , Zhang Shipin , Tan Sharon Si Heng , Cheow Yi Ann , Lai Ruenn Chai , Lim Sai Kiang , Hui James Hoi Po , Toh Wei Seong 
Published: February 2022

Background:
The objective of this study was to examine the therapeutic effects of human mesenchymal stromal/stem cell (MSC) exosomes in a rat model of growth plate injury.

Methods:
A growth plate defect was surgically created on the distal part of the right femur of 40 female Sprague-Dawley rats. A single intra-articular injection of 100 µg of MSC exosomes in 100 µL of phosphate-buffered saline solution (PBS), or an equivalent volume of PBS alone, was administered to the right knee immediately after surgery. At 4 and 8 weeks post-treatment, limb length was measured with micro-CT, and tissue repair was assessed with histological, immunohistochemical, and histomorphometric analyses.

Results:
A single injection of MSC exosomes significantly increased limb length from 3.29 ± 0.07 cm at 4 weeks to 3.37 ± 0.11 cm at 8 weeks (p = 0.047). However, no improvement in limb length was observed in the PBS control group. The limb-length discrepancy between the involved limb and the contralateral limb in the exosome-treated group was significantly less than the discrepancy in the PBS-treated group at both 4 weeks (2.52% ± 1.30% versus 4.11% ± 0.93%; p = 0.006) and 8 weeks (5.27% ± 2.11% versus 8.06% ± 2.56%; p = 0.016). Consistent with the reduced limb-length discrepancy, the exosome-treated defects displayed significantly more chondrocytes (p < 0.05) and a higher area percentage with deposition of sulphated glycosaminoglycan (p < 0.05) and collagen II (p < 0.05) than PBS-treated defects at 8 weeks. However, bone bridge formation was not inhibited in either group.

Conclusions:
A single intra-articular injection of MSC exosomes significantly enhanced physeal repair and reduced limb-length discrepancy but did not inhibit bone-bridge formation.

Clinical Relevance:
This proof-of-concept study demonstrates for the first time the potential use of MSC exosomes as a minimally invasive cell-free therapeutic to promote physeal repair and reduce limb-length discrepancy following growth plate injuries.
Baby Dumping in Malaysia and Indonesia: Between National Regulation and Islamic Criminal Law
Authors: Hasan Maisyarah Rahmi , Azman Nik Nor Azeah Nik 
Published: February 2022

This study aims to analyze the problem of baby dumping that happened in Malaysia and Indonesia according to regulation and Islamic Law (Fiqh al-Jinayah). As known, both countries are majority Muslims population which have similarities in terms of culture and customs. However, baby dumping cases are still happening in these countries, increasing every year. So it needs to be studied more deeply, considering that both countries have implemented laws related to the prohibition of baby dumping. This research is a normative method by descriptive qualitative type. This study concludes that baby dumping cases are not a light problem but a big problem that must resolve with the support of all parties. Some factors that influence a person in baby dumping cases are pregnancies outside of marriage, lack of education with knowledge of sex, embarrassment with the surrounding community. From the laws regulated in Malaysia and Indonesia, the perpetrators of this baby disposal can be subject to the most severe punishment as regulation implemented in both countries. However, the punishment for the perpetrators is still limited to imprisonment. Even if the perpetrators are children, child protection rules are applied. This punishment in Islam is categorized as ta'zir punishment.
Keywords: Baby Dumping, Children, Islamic Law, Islamic Criminal Law
Resistensi Dan Ambivalensi Dalam Novel Al-Yaum Al-Maw’ud Karya Najib Kailani
Authors: Nurhasanah Ira 
Published: February 2022

Tulisan ini memiki objek material novel modern Mesir yang berjudul al-Yaum al-Maw’ud karya Najib al-Kailani. Novel ini mengisahkan perjuangan rakyat Mesir di bawah pimpinan Raja Najmuddin Ayun melawan tantara Salib Perancis yang dIpimpin oleh Pangeran Louis. Adapun yang menarik dari novel ini adalah adanya resistensi yang variatif yang dilakukan oleh berbagai kalangan, serta sikap ambivalensi yang sangat kental dipraketkan oleh tokoh penjajah. Sementara itu, objek formalnya adalah teori post kolonial dengan memakai metode dekonstruksi. Teori ini didasarkan pada gugatan Edward Said dalam karyanya “orientalism” yang memiliki landasan epistiemologis, ontologis, dan aksiologis menyasar pada kepentingan kolonial. Barat dan Timur yang diposisikan sedemikian rupa, menurut Said sudah melanggar nilai-nilai kemanusiaan dan harus dikembalikan kepada tempatnya. Hasil dari penelitian itu menunjukan bahwa oposisi biner Barat dan Timur yang selalu dikaitkan dengan berperadaban dan terbelakang, positif dan negatif, putih dan hitam, yang tidak sepenuhnya benar. Hal ini tampak dalam masif dan variatifnya resistensi yang diberikan oleh masyarakat Mesir dan bangsa Arab. Selain itu, ketidaktepatan tindakan Barat terhadap Timur juga dicerminkan oleh ambivalensi yang ditampilkan oleh Marseil sebagai tantara Perancis. Dengan demikian, berarti kolonialisasi yang dilakukan oleh Barat yang mengatasnamakan dirinya negara superior kepada Timur yang dianggap inferior telah mekanggar nilai-nilai kemanusiaan
Sosok Perempuan Dalam Puisi “Asyhadu An Lâ Imra’ata Illâ Anti” Karya Nizar Qabbani
Authors: Hayati Dewi Lutfiana , Syafaah Daris 
Published: February 2022

Abstract
Poetry research with the title "I witness that there is no woman Apart From You" by Nizar Qabbani. Poetry has beautiful words that describe social conditions even to the point of economic and political. The purpose of this study was to find out the meaning contained in the poem "I witness There Is No Woman Besides You and to know the aspects of the signified and the aspect of the signifier. The form of the formulation of the problem contained in this poem are: 1) What are the characteristics of women in the poem "I bear witness that there is no woman but you"? 2) How does the female figure compare the poet to the poem?. The method used in this study uses qualitative methods. And this research was studied using semiotic analysis. Semiotics is the study of signs and meanings contained in literary works. The findings of this study are that there are aspects of signifier and signified . the characteristics of women described in the verses of the poem "I witness there is no woman but you". While the results of the research in this poem explain the figure of a woman, namely the most loved wife, who is able to nurture and care for her patiently which is like taking care of her young child, tough, affectionate, patient and able to accompany the poet in times of joy and sorrow.
Keywords: Poetry, I Witness There Is No Woman Apart From You, Semiotics

Asbtrak
Penelitian puisi dengan judul “ Asyhadu An La> Imra’ ata Illa< Anti ” karya Nizar Qabbani. Puisi memiliki kata-kata yang indah yang menggambarkan keadaan sosial bahkan sampai ekonomi dan politik. Tujuan penelitian ini untuk mengetahui makna yang terkandung dalam puisi “Aku Bersaksi Tiada Perempuan Selain Engkau, dan mengetahui aspek petanda dan paspek penanda. Bentuk rumusan masalah yang terdapat dalam puisi ini yaitu: 1) Bagaimana sifat-sifat wanita yang terdapat dalam puisi “Aku Bersaksi Tiada Perempuan Selain Engkau”? 2) Bagaimana sosok wanita tersebut mengumpamakan sang penyair pada puisi tersebut?. Adapun metode yang digunakan dalam penelitian ini menggunakan metode kualitatif. Dan penelitian ini dikaji menggunakan analisis semiotika. Semiotika adalah ilmu yang mengkaji tentang tanda dan makna yang terdapat dalam karya sastra. Adapun temuan dari penelitian ini yaitu terdapat aspek petanda dan penanda, sifat-sifat wanita yang dijelaskan pada bait-bait puisi “Aku Bersaksi Tiada Perempuan Selain Engkau”. Sedangkan hasil penelitian dalam puisi ini menjelaskan sosok wanita yaitu istri yang paling dicintai, yang mampu mengayomi serta merawat dengan telaten yang diibaratkan seperti merawat anaknya yang masih kecil, tangguh, kasih sayang, penyabar dan mampu mendampingi sang penyair dalam keadaan suka maupun duka.
Kata Kunci: Puisi, Aku Bersaksi Tiada Perempuan Selain Engkau, Semiotika
Identification of Strata from Irregularities in Well Logs Using Chaos Quantifiers
Authors: Figiel Michal , Lewandowska-Smierzchalska Joanna 
Published: February 2022

Summary
Estimating a transition between rock types from well logs using traditional methods can be challenging and time-consuming. Developing new approaches to improving the quality of the estimation as well as saving time becomes necessary. This paper presents a new methodology that uses elements of chaos theory to evaluate the variability of well logs to identify rock layers.
Four different parameters that quantify chaos were used in the present study: fractal correlation dimension, sample entropy, Hurst exponent, and Lyapunov exponent. Each of them describes a different property of a well log. The method presented in this paper uses all of them together for an extensive characterization of well log irregularities. The study was carried out on a set of 68 well logs from six wells in the Pluto gas field (Australia). The logs were divided into segments of 25 m. A computer program was written to calculate the chaos parameter values of each interval. The parameters were then analyzed statistically. Hierarchical methods and k-means clustering were used to create dendrograms and clusters.
The statistical analysis of the results has shown that the well log variability can be used to successfully differentiate rock formations by showing which intervals on a log are similar. In addition, the intervals that correspond to Mungaroo sandstones, which are the reservoir rock of the Pluto gas field, were particularly distinguished from other parts of the log. Therefore, the presented methodology could prove useful to estimate zones of interest in terms of hydrocarbon potential.
The presented algorithm accounts for the variability of the well log readings, not the log values themselves. It does not point exactly to a depth where rock layers interface, but it rather allows similar (in terms of irregularities), consecutive intervals to be grouped together. Based on that, one can draw a conclusion that a lithology differs between groups of intervals.
Conscience Clause in the Professional Practice of a Nurse and Midwife: A Cross-Sectional Study
Authors: Iwanowicz-Palus Grażyna , Mróz Mariola , Kruczek Agnieszka , Rusińska Anna , Szlendak Beata 
Published: February 2022

Abstract
Background
Attitudes toward the conscience clause are a manifestation of the compromise between the conscience of the health care provider and the welfare of the patient. The aim of the study is to distinguish types of approaches of nurses and midwives to the conscience clause and factors that affect them.
Methods
The research was conducted by means of the Generalized Self-Efficacy Scale (the GSES) and a standardized questionnaire in the group of 270 nurses and 262 midwives (Poland).
Results
Nurses are characterized by three types of attitudes to the conscience clause: radically conservative, radically liberal as well as liberal-conservative. In the group of midwives moderately liberal, rational-liberal and radically conservative types of approaches were found. Factors that differentiate the attitude of nurses and midwives to the conscience clause include type of medical procedure, place of residence, education, maternal experience, seniority, attitude to faith in God and self-efficacy.
Conclusions
It is desirable for nursing and midwifery professionals to take steps toward addressing moral dilemmas through education, well-designed workplace guidelines, and engagement in research to uncover underlying barriers.
Fruquintinib in Combination with PD-1 Inhibitors in Patients with Refractory Non-MSI-H/pMMR Metastatic Colorectal Cancer: A Real-World Study in China
Authors: GOU miaomiao , Qian Niansong , Zhang Yong , Yan Huan , Si Haiyan , wang zhikuan , Dai Guanghai 
Published: February 2022

Abstract
Background: Fruquintinib, a vascular endothelial growth factor receptor inhibitor, is a new anti-cancer drug independently developed in China to treat refractory metastatic colorectal cancer (mCRC). In Japan, regorafenib in combination with nivolumab has demonstrated promise in patients with refractory mCRC. Here, in a real-world study, we aimed to evaluate the efficacy of fruquintinib plus various programmed death-1 (PD-1) inhibitors after standard treatment in Chinese non- microsatellite instability-high(MSI-H)/mismatch repair proficient mCRC patients.Methods: Thirty-five patients with refractory mCRC were involved in the study. They were given fruquintinib (3 or 5 mg orally, once daily for 3 weeks followed by 1 week off in 4 week cycles) and a PD-1 inhibitor. Progression free survival (PFS), overall survival (OS), disease control rate (DCR), and objective response rate (ORR) were reviewed and evaluated. Results: Of the 35 patients, the median age was 54 years (29–85). The ORR was 11.4% (4/35), DCR was 60% (21/35), median PFS was 3.8 months, and median OS was 14.6 months. The duration of response was 3.4 months. The PFS between left and right primary tumors as well as whether lung metastases were present did not differ (p > 0.05), which is inconsistent with the REGONIVO study. The multivariate analysis indicated no association of OS benefit in the specified subgroups. No adverse-effect-related deaths were reported.Conclusions: Fruquintinib in combination with anti-PD-1 was observed to have clinical activity in a small population of patients with heavily pretreated mCRC. The improvements in OS need to be verified using more real-world medical data.