bluuebunny/crossref_metadata_2025_split huggingface dataset:
Activity‐guided purification and identification of endogenous bioactive peptides from barley sprouts (Hordeum vulgare L.) with diabetes treatment potential
Authors: Gumus Zinar Pinar , Moulahoum Hichem , Tok Kerem , Kocadag Kocazorbaz Ebru , Zihnioglu Figen 
Published: November 2022

SummaryMetabolic‐associated disorders such as blood pressure and type 2 diabetes (T2D) are some of modern society's widespread problems. While there are many beneficial treatments, the quest for “safe” alternatives using natural products (e.g., cereals) is of great promise, especially plant‐based peptides containing inherently endogenous bioactivities that can provide multiple health‐promoting effects. Here, we aimed to purify and identify potential endogenous peptides of barley sprouts through an activity‐guided process with a potential T2D therapeutical effect. Barley seeds were germinated, and sprouts were fractionated through ultrafiltration followed by RP‐HPLC. All peptide fractions were examined for various bioactivities (α‐glucosidase/DPP4 inhibition, antiglycation, antioxidant and metal chelation activities). LC‐Q‐TOF‐MS/MS was employed for sequence identification of the fraction with the highest activity level. The data demonstrated that fractions with molecular weights lower than 3 kDa were the only ones with antiglycation activities. The RP‐HPLC of the 3 kDa fraction resulted in 11 fractions, including 4 having significant IC50/EC50 levels. F11 demonstrated the highest potential as T2D treatment, and the sequence identification provided the sequences SQQENELTSLIVESNNRFNNASNT. Natural bioactive peptides from easy to procure and cheap sources are promising molecules for therapeutic applications. Further in vivo and clinical testing are necessary to validate the current findings.
Increased antioxidant and antimicrobial activities of lemongrass and cinnamon essential oils with tea polyphenols and its application in the preservation of marine fish
Authors: Zhou Qing , He Dong , Yu Hongpeng , Yang JinJin , Wu Kegang , Duan Xuejuan , Wu Xiqin , Han Xiaofang 
Published: November 2022

SummaryPlant essential oils have great potential to become a new generation of marine fish preservatives, and the key to the application of essential oil in fresh‐keeping is to improve its cost performance. In this study, the combined effect of 0.008 g/mL lemongrass essential oils and 0.01 g/mL cinnamon essential oils with different concentration (0, 0.005, 0.01, 0.03, 0.05 g/mL) of tea polyphenols on the antioxidant activity and antimicrobial activity in vitro, and application in marine fish preservation was studied. The in vitro tests showed that the combination of essential oils with tea polyphenols increased the antioxidant and antimicrobial activities compared with the essential oils or tea polyphenols alone. During the preservation of the marine fish Dusky Spinefoot, the combination of essential oils with tea polyphenols slightly inhibited microbial growth, but greatly reduced the visible decay on the surface of fish flavour deterioration and biogenic amine production. Antimicrobial activities were also observed in films prepared combining essential oil and tea polyphenols. These combined effects are meaningful and provide prospects for expanding the application of essential oil and developing a new hurdle technology for marine fish storage.
Noninvasive ventilation in New Zealand: a national prevalence survey
Authors: Neill Alister , Ingham Tristram R. , Perry Meredith , Aldridge Daniel , Miller James , Jones Bernadette 
Published: November 2022

AbstractBackgroundHome‐based noninvasive ventilation (NIV) is an effective treatment for a range of conditions that cause respiratory failure which reduces hospitalisation and mortality and improves quality of life.AimsTo collect NIV prevalence, disease burden and equity data needed for effective national NIV health service planning.MethodsThe authors collected demographics and the primary diagnosis of patients receiving publicly funded NIV in New Zealand in 2018 by surveying all providers. National and regional prevalence rates were calculated using adult population data (aged ≥20 years) for each District Health Board region compared with a 2011 study. A subanalysis of individual‐level data was used to calculate age‐standardised rates by diagnostic category.ResultsA total of 1197 adults were receiving NIV giving a national rate of 32.9 per 100 000; almost twice the 2011 rate (16.7 per 100 000). Significant regional variations in NIV provision (4.5–84.2 per 100 000) were observed. The most frequent indications were obesity hypoventilation syndrome (OHS) (562, 47%), obstructive pathologies (335, 28%) and neuromuscular disorders (175, 15%); all have significantly increased in prevalence since 2011. Māori and Pacific peoples were significantly overrepresented among NIV users (2.24 [95% confidence interval (CI), 1.72–2.93] and 7.03 [95% CI, 5.52–8.94], respectively). The prevalence of NIV‐dependent use (>15 h/day) was 4%.ConclusionsHome‐based NIV provision has doubled since the previous survey, reflecting increased burden from OHS and obstructive pathologies and a disproportionate disease burden among Māori and Pacific populations. The large regional variations are concerning and highlight the urgent requirement for national service specifications, education and equipment provision. Further research is needed to address access equity.
When does FDI make a difference for growth? A comparative analysis of resource‐rich and resource‐scarce African economies
Authors: Yimer Addis 
Published: November 2022

AbstractThis study revisits the foreign direct investment (FDI)–growth nexus in Africa, categorizing countries as resource‐rich or resource‐scarce for the period 2000–2017 in an attempt to capture the impact that cross‐country natural resource endowment differences may have on the FDI–growth relationship. Thus, the study is an attempt to answer the question: Does being a natural resource‐abundant or resource‐scarce country alter the FDI‒growth nexus? Using the System Generalized Method of Moments, it is found that the effects of FDI on economic growth vary depending on countries' resource richness. While FDI affects growth positively and significantly in the resource‐scarce category, the size of such an effect varies across countries within the group. The better the human capital and institutions, the higher the FDI‐induced growth. However, no effect of FDI on growth has been identified for the resource‐rich category. The findings suggest that African countries in general, and resource‐rich economies in particular, need to look carefully and critically at the type of FDI inflows they receive.
Development of morning–eveningness in adolescence: implications for brain development and psychopathology
Authors: Cooper Rebecca , Di Biase Maria A. , Bei Bei , Allen Nicholas B. , Schwartz Orli , Whittle Sarah , Cropley Vanessa 
Published: November 2022

BackgroundMorning–evening preference is defined as an individual's preference for a morning‐ or evening‐oriented rhythm. Across adolescence, a preference for eveningness becomes more predominant. Although eveningness is cross‐sectionally associated with internalizing and externalizing psychopathology, few studies have examined developmental changes in eveningness and its potential biological substrates. Here, we investigated the longitudinal relationships among the trajectory of eveningness preference, internalizing and externalizing psychopathology and white matter development, across adolescence.MethodsTwo‐hundred and nine adolescents (49% male) were assessed longitudinally at four separate time points between 12 and 19 years of age. Morning–evening preference and internalizing and externalizing symptoms were assessed at each time point. Diffusion‐weighted images were acquired on a subset of participants at the final two time points to estimate changes in global mean fractional anisotropy (FA). Linear mixed models were performed to estimate the change in eveningness over time. A series of linear regression models assessed the influence of change in eveningness on psychopathology and white matter development at age 19.ResultsAcross the sample, a preference for eveningness became more predominant by 19 years of age. Greater individual‐level change towards eveningness significantly predicted greater severity in externalizing, but not internalizing, symptoms at 19 years of age. In contrast, change in psychopathology from 12 to 19 years of age was not associated with morning–eveningness at age 19. A change towards eveningness predicted an attenuated increase in FA between 17 and 19 years of age.ConclusionsThis study suggests that developmental changes in morning–evening preference may predict both neurodevelopmental and psychological outcomes in adolescents.
Horizontal inequalities, political violence, and nonviolent conflict mobilization: A review of the literature
Authors: Hillesund Solveig , Østby Gudrun 
Published: November 2022

AbstractThe association between horizontal inequalities (HIs) and civil war is well established. Yet, studies of HIs and civil war rarely specify why HIs should lead to conflict that is violent, organized, and large‐scale, such as civil war. Collective mobilization outside conventional political channels could take many other forms, such as demonstrations, strikes, riots or communal conflicts. Recently, researchers have begun to investigate whether HIs increase the risk of nonviolent, less organized, and smaller‐scale conflict. This article provides the first systematic review of the emerging quantitative literature on the impact of HIs on both violent and nonviolent conflict mobilization. We ask: Do HIs increase all mobilization outside conventional political channels, or do they shape what form of conflict breaks out? We supplement previous reviews of the literature on HIs and political violence with a systematic update for scholarly articles published in 2017–2022. This yielded 22 new articles. Furthermore, we identify 20 articles on HIs and nonviolent conflict published in 1996–2022. The review reveals that while there is robust evidence on the relationship between HIs and violent mobilization, the emerging evidence on nonviolent conflict is inconsistent. We conclude by discussing potential reasons for this inconsistency.
miR‐101‐3p contributes to the progression of preeclampsia by suppressing WDR5‐mediated proliferation and invasion of trophoblast
Authors: Zhao Xudong , Su Fengyun , Kong Fanhua , Guo Qing , Wang Xiuzhu , Cui Hong , Li Qinwen , Zhang Wangmeng , Li Lei , Li Aihua 
Published: November 2022

AbstractBackgroundDecreased proliferation and invasion of trophoblast were proven to be involved in the pathogenesis of preeclampsia (PE). However, the regulatory network has not been clarified yet. This study aimed to explore the role of miR‐101‐3p in the progression of PE.MethodsmiR‐101‐3p expression in placentas of pregnant women with or without PE was analyzed by real‐time quantitative PCR (RT‐qPCR). Trophoblastic HTR‐8/SVneo and HPT‐8 cell lines were cultured and underwent hypoxia/reoxygenation (H/R) treatment to mimic PE in vitro. Cell proliferation and invasion were analyzed in gain‐of and loss‐of‐function assays. Finally, we undertook in vivo studies to explore effects of miR‐101‐3p in the PE model.ResultsCompared to placentas from patients without PE, miR‐101‐3p expressed significantly higher in placentas from PE patients, and its level was positively correlated with the severity of patients. In vitro studies found that overexpression of miR‐101‐3p significantly suppressed cell proliferation and invasion, while knockdown of miR‐101‐3p reversed the impacts of H/R treatment. Further research showed that the expression of WD repeat domain 5 (WDR5) was significantly lower in placentas from patients with PE, and its level was negatively associated with the severity of patients. In vitro and in vivo studies confirmed that miR‐101‐3p promoted PE progression through the regulation of WD WDR5 expression.ConclusionIncreased expression of miR‐101‐3p in placenta contributes to the development of PE by suppressing WDR5‐mediated proliferation and invasion of trophoblast.
The red blood cell as a mediator of endothelial dysfunction in patients with familial hypercholesterolemia and dyslipidemia
Authors: Mahdi Ali , Wodaje Tigist , Kövamees Oskar , Tengbom John , Zhao Allan , Jiao Tong , Henricsson Marcus , Yang Jiangning , Zhou Zhichao , Nieminen Anni I. , Levin Malin , Collado Aida , Brinck Jonas , Pernow John 
Published: November 2022

AbstractBackgroundPatients with familial hypercholesterolemia (FH) display high levels of low‐density lipoprotein cholesterol (LDL‐c), endothelial dysfunction, and increased risk of premature atherosclerosis. We have previously shown that red blood cells (RBCs) from patients with type 2 diabetes induce endothelial dysfunction through increased arginase 1 and reactive oxygen species (ROS).ObjectiveTo test the hypothesis that RBCs from patients with FH (FH‐RBCs) and elevated LDL‐c induce endothelial dysfunction.Methods and resultsFH‐RBCs and LDL‐c >5.0 mM induced endothelial dysfunction following 18‐h incubation with isolated aortic rings from healthy rats compared to FH‐RBCs and LDL‐c <2.5 mM or RBCs from healthy subjects (H‐RBCs). Inhibition of vascular but not RBC arginase attenuated the degree of endothelial dysfunction induced by FH‐RBCs and LDL‐c >5.0 mM. Furthermore, arginase 1 but not arginase 2 was elevated in the vasculature of aortic segments after incubation with FH‐RBCs and LDL‐c >5.0 mM. A superoxide scavenger, present throughout the 18‐h incubation, attenuated the degree of endothelial dysfunction induced by FH‐RBCs and LDL‐c >5.0 mM. ROS production was elevated in these RBCs in comparison with H‐RBCs. Scavenging of vascular ROS through various antioxidants also attenuated the degree of endothelial dysfunction induced by FH‐RBCs and LDL‐c >5.0 mM. This was corroborated by an increase in the lipid peroxidation product 4‐hydroxynonenal. Lipidomic analysis of RBC lysates did not reveal any significant changes across the groups.ConclusionFH‐RBCs induce endothelial dysfunction dependent on LDL‐c levels via arginase 1 and ROS‐dependent mechanisms.
Effects of COVID‐19 on sensory and cognitive perception of mild and severe diagnosed and recovered patients versus healthy consumers
Authors: Cabal‐Prieto Adan , Sánchez‐Arellano Lucía , Herrera‐Corredor José Andrés , Rodríguez‐Miranda Jesús , Prinyawiwatkul Witoon , Ramón‐Canul Lorena Guadalupe , Toledano‐Toledano Filiberto , Rodríguez‐Buenfil Ingrid Mayanin , Ramírez‐Sucre Manuel Octavio , Hernández‐Salinas Gregorio , de Ramírez‐Rivera Emmanuel de Jesús 
Published: November 2022

AbstractThe objective of this research was to analyze the effects of the SARS‐CoV‐2 virus on the sensory and cognitive perception of mild and severe COVID‐19 diagnosed and recovered consumers versus healthy consumers. Three groups of 50 consumers each (healthy vs. mild and severe COVID‐19 diagnosed with 30 days after recovery) were used for the evaluation of instant coffee stimuli in concentrations: 4.40, 2.93, 2.20, 1.76, and 1.47% weight (w)/volume (v) and determine their discriminating power, emotions, and memories. Sensory tests were performed remotely. Results indicated that healthy consumers perceived higher intensities in most of the sensory attributes (with the exception of Burnt‐A, Bitter‐T, Acid‐T, and Astringent‐T attributes) compared to consumers who presented mild and severe COVID‐19. Therefore, consumers diagnosed with mild and severe COVID‐19 had a higher discrimination power in the attributes smell, basic tastes, and flavor. Healthy consumers could only discriminate two attributes that correspond to basic flavors. Consumers with mild and severe COVID‐19 diagnosis elicited the highest number of negatives emotions (such as bored, disgusted, worried, guilty, wild, and aggressive) and negative memories (disease, pain, death, hurt, obesity, conflict personal, addiction, stench poverty, and accident) than healthy consumers. It is concluded that there were no significant differences between the consumer panels for the identification of sensory attributes. However, P‐Healthy consumers perceived the highest intensities in most sensory attributes compared to those in the PCOVID19‐Mild and PCOVID19‐Severe panels. Finally, consumers diagnosed with mild or severe COVID‐19 used a higher number of emotions and memories than those of the healthy panel.Practical applicationsInvestigating the effects of COVID‐19 on sensory and cognitive perception can be useful for industry and researchers in the sensory field who wish to understand the effects of the disease in order to generate new protocols for the selection and training of people, as well as the possible development and innovation of new products focused on perception of consumers recovered from COVID‐19.
Excessive and asymmetrical removal of heterozygous sites by maxSH biases downstream population genetic inference: Implications for hybridization between two primroses
Authors: Zhang Jie , Pina‐Martins Francisco , Jin Zu‐Shi , Cha Yong‐Peng , Liu Zu‐Yao , Peng Jun‐Chu , Zhao Jian‐Li , Li Qing‐Jun 
Published: November 2022

AbstractTechniques of reduced‐representation sequencing (RRS) have revolutionized ecological and evolutionary genomics studies. Precise establishment of orthologs is a critical challenge for RRS, especially when a reference genome is absent. The proportion of shared heterozygous sites across samples is an alternative criterion for filtering paralogs. In the prevailing pipeline for variant calling of RRS data – PYRAD/IPYRAD, maxSH is an often overlooked parameter with implications to detecting and filtering paralogs according to shared heterozygosity. Using empirical genotyping by sequencing data of two primroses (Primula alpicola Stapf and Primula florindae Ward) and their putative hybrids, and extra data sets of Californian golden cup oaks, we explore the impact of maxSH on filtering paralogs and further downstream analyses. Our study sheds light on the simultaneous validity and risk of filtering paralogs using maxSH, and its significant effects on downstream analyses of outlier detection, population assignment, and demographic modeling, emphasizing the importance of attention to detail during bioinformatic processes. The mutual confirmation between results of population assignment and demographic modeling in this study suggested maxSH = 0.10 has a potentially excessive and asymmetrical effect on the removal of truly shared heterozygous sites as paralogs. These results indicate that hybridization origin hypotheses of putative hybrids represented by results with maxSH = 0.25 and 0.50 are more credible. In conclusion, we revealed the critical hazard of paralogs filtration according to sharing heterozygosity at first, so that we propose to use specific protocols, rather than maxSH, to filter potential paralogs for closely related lineages.
Artificial liver support systems for hepatitis B virus‐associated acute‐on‐chronic liver failure: A meta‐analysis of the clinical literature
Authors: Li Guotao , Zhang Pan , Zhu Yumeng 
Published: November 2022

AbstractTo evaluate the short‐term and long‐term survival efficacy of an artificial liver support system (ALSS) in patients with acute‐on‐chronic liver failure (ACLF). A systematic search was performed for relevant published data in PubMed, Web of Science and Cochrane Library databases. Studies that evaluated the efficacy of ALSS in patients with ACLF and provided the short‐term or long‐term survival rate were included. A total of 10 studies involving 3685 patients were included in this analysis. The pooled 28‐day survival rate and 90‐day survival rate were 68.7% (95% CI: 64.5%–72.9%) and 53.4% (95% CI: 45.5%–61.4%), respectively. The pooled estimates of the OR for the 28‐day and 90‐day survival rates between the ALSS group and the control group were 1.91 (95% CI: 1.21–3.04) and 1.41 (95% CI: 1.17–1.70), respectively. Subgroup analysis showed that patients treated with lower levels of TBIL and MELD scores had a higher 28‐day survival rate (χ2 = 15.75, p < 0.01; χ2 = 13.80, p < 0.01). The present meta‐analysis suggests that ALSS treatment could remarkably improve short‐term survival rates in HBV‐ACLF patients, which implies that treatment with ALSS may help to reduce high mortality. Further prospective randomized trials are needed to validate these findings.
Trust as performance
Authors: Carter J. Adam 
Published: November 2022

AbstractIt is argued that trust is a performative kind and that the evaluative normativity of trust is a special case of the evaluative normativity of performances generally. The view is shown to have advantages over competitor views, e.g., according to which good trusting is principally a matter of good believing (e.g., Hieronymi, 2008; McMyler, 2011), or good affect (e.g., Baier, 1986; Jones, 1996), or good conation (e.g., Holton, 1994). Moreover, the view can be easily extended to explain good (and bad) distrust, where the latter is understood as aimed (narrow‐scoped) forbearance from trusting. The overarching framework—which assimilates the evaluative norms of trusting (and distrusting) to performance‐theoretic norms—supplies us with an entirely new lens to view traditional philosophical problems about what is involved in trusting and distrusting well and badly, and thus, places our capacity to make progress on problems in this area on a new footing.
Cumulative risk exposure and child cellular aging in a Dutch low‐risk community sample
Authors: Beijers Roseriet , ten Thije Ilse , Bolhuis Emma , O'Donnell Kieran J. , Tollenaar Marieke S. , Shalev Idan , Hastings Waylon J. , MacIsaac Julia L. , Lin David T. S. , Meaney Michael , Kobor Michael S. , Belsky Jay , de Weerth Carolina 
Published: November 2022

AbstractOne of the proposed mechanisms linking childhood stressor exposure to negative mental and physical health outcomes in later life is cellular aging. In this prospective, longitudinal, and pre‐registered study, we examined the association between a cumulative pattern of childhood risk exposure from age 6 to age 10 (i.e., poor maternal mental health, parental relationship problems, family/friend death, bullying victimization, poor quality friendships) and change in two biomarkers of cellular aging (i.e., telomere length, epigenetic age) from age 6 to age 10 in a Dutch low‐risk community sample (n = 193). We further examined the moderating effect of cortisol reactivity at age 6. Ordinary Least Squares regression analyses revealed no significant main effects of childhood risk exposure on change in cellular aging, nor a moderation effect of child cortisol reactivity. Secondary findings showed a positive correlation between telomere length and cortisol reactivity at age 6, warranting further investigation. More research in similar communities is needed before drawing strong conclusions based on the null results.
Environmental disasters and mental health: Evidence from oil spills in the Peruvian Amazon
Authors: Chong Alberto , Srebot Carla 
Published: November 2022

AbstractUsing a difference‐in‐difference approach, we test the causal link between environmental disasters and mental health indicators in rural areas of Peru by exploiting the spatial variation in exogenous oil spills and the differences in their timing for the period 2014 to 2018. We find that, after controlling for time‐varying controls and year fixed effects, oil spills lead to a significantly higher probability of suffering psychological distress. We also explore likely mechanisms that explain this causal impact. Finally, we present an event study and apply robustness tests that further support our findings.