bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Microphysics-Scheme-Consistent Snow Optical Parameterization for the Community Radiative Transfer Model
Authors: Ren Tong , Yang Ping , Garrett Kevin , Ma Yingtao , Ding Jiachen , Coy James 
Published: October 2022

Abstract
The satellite observational data assimilation community requires consistent hydrometer descriptions—including mass–size relation and particle size distribution—to be used in both the forecast model and observation operator. We develop a microphysics-scheme-consistent snow and graupel single-scattering property database to meet this requirement. In this database, snowflakes are modeled as a mixture of small column and large aggregated ice particles, the mixing ratios of which may be adjusted to satisfy a given mass–size relation. Snow single-scattering properties are computed for four different mass–size relations. Subsequently, the snow description in the Thompson microphysics scheme is used as an example to demonstrate how microphysics-scheme-consistent snow bulk optical properties are derived. The Thompson-scheme-consistent snow bulk optical properties are added to the Community Radiative Transfer Model (CRTM), version 2.4.0. With CloudSat Cloud Profiling Radar (CPR) snow and liquid precipitation retrievals as the inputs, CRTM simulations are performed over global oceans and compared with four collocated Global Precipitation Measurement (GPM) Microwave Imager (GMI) high-frequency channel observations. The CRTM simulated brightness temperatures show agreement with the GMI observed brightness temperatures in cases of light-to-moderate precipitation over extratropical and polar ice-free oceans, with root-mean-square errors of 4.3, 13.0, 1.8, and 3.3 K in the 166-GHz (vertical polarization), 166-GHz (horizontal polarization), 183 ± 3-GHz (vertical polarization), and 183 ± 7-GHz (vertical polarization) channels, respectively. The result demonstrates the potential of using the newly developed microphysics-scheme-consistent snow optical parameterization in data assimilation applications.
Directional porous polyimide/polyethylene glycol composite aerogel with enhanced CO2 uptake performance
Authors: Nie Yihao , Yi Xibin , Zhao Xinfu , Yu Shimo , Zhang Jing , Liu Xiaochan , Liu Sijia , Yuan Zhipeng , Zhang Minna 
Published: October 2022

The cost of CO2 separation and energy consumption can be decreased through the use of CO2 adsorption. Due to the electron-rich heteroatoms in its network, polyimide (PI) has a remarkable affinity for CO2. Polyethylene glycol (PEG) can increase the layer spacing of polymers, so as to change the mass transfer of CO2 in it. Furthermore, the ether bond (-O-) in PEG has good affinity for CO2. In this study, PEG-1000 was introduced into PI aerogel by mild sol-gel method at low temperature, and freeze-drying was used to produce PI/PEG composite aerogels with directional pore structure. The effect of PEG-1000 content and directional pore structure of the PI/PEG composite aerogels on CO2 adsorption performance were further studied. The L-PI/PEG-4 composite aerogel, which contains 4 g PEG and is directionally frozen in liquid nitrogen, has a CO2 adsorption capacity of 16.76 cm3/g at 25°C and 1 bar. L-PI/PEG-4 aerogel also exhibits high CO2/N2 selectivity and adsorption cycle stability.
The Twitter factor: How does Twitter impact #Stroke journals and citation rates?
Authors: Sousa João André , Alves Inês Alexandra , Donato Helena , Sargento-Freitas João 
Published: October 2022

Background: Twitter is a social media platform popularly used by health practitioners, a trend that has been followed by medical journals. The impact of Twitter in bibliometrics of stroke-related literature is yet to be determined. Aims: We aimed to qualitatively assess the usage of Twitter by stroke journals and study the relationship between Twitter activity and citation rates of stroke articles. Methods: We used Journal Citation Reports to identify stroke journals. We collected the 2021 Impact Factor (IF) and the top 50 articles contributing to each journal IF. Relevant metrics were collected through Twitonomy, Altmetric, and Web of Science. The association between Twitter activity and citation rates was tested by a negative binomial regression model adjusted to journal’s IF. A bivariate correlation and a log-linear regression model adjusted to journal’s IF tested the relationship between number of tweets, tweeters, and the number of citations. Results: We collected 450 articles across nine stroke-dedicated journals, five of which had a Twitter account. Only 95 (21%) articles had no Twitter mentions. The median number of citations in articles with versus without Twitter activity was 19 (10–39) versus 11(7–17) ( P < 0.001). Twitter activity was associated with higher citation rates controlling for the IF (odds ratio (OR): 2.7, 95% confidence interval (CI) 2.12–3.38, P < 0.001). We found number of tweets to be predicted by the number of citations controlling for the IF (B = 0.33, 95% CI 0.29–0.40, β = 0.54, P < 0.001). Conclusions: Tweeted stroke articles tend to have higher citation rates which can be predicted by the number of tweets.
Sexually objectifying work environments and affective commitment in a sample of Italian waitresses: The mediating role of anxiety and job satisfaction
Authors: Cabras Cristina , Sechi Cristina , Mula Silvana 
Published: October 2022

Background: Sexual objectification can assume various forms, from interpersonal to cultural and environmental ones. Previous research has highlighted how working in sexually objectifying environments (SOEs) can lead female workers to experience negative feelings (i.e. anxiety, job dissatisfaction). The study’s main aim was to investigate the relationships between sexually objectifying work environments, job satisfaction, anxiety, and affective commitment. Design and method: In this study, we investigated the role of working in sexually objectifying environments (i.e. bars and pubs) in triggering female workers’ (i.e. waitresses) feelings of anxiety and in decreasing their job satisfaction and their affective organizational commitment. Our hypothesis was tested through a mediation model with a sample of ( N = 546) Italian restaurant/bar waitresses. Results: The results supported a model in which sexually objectifying environments had a direct effect on job satisfaction and both direct and indirect effects on anxiety. Further, sexually objectifying environments indirectly affected affective commitment through both anxiety and job satisfaction. Conclusion: Working in a perceived sexually objectified environment can raise waitresses’ feelings of anxiety and job satisfaction. These feelings, in turn, negatively affect workers’ affective commitment toward their workplace. The limitations and implications of this study were discussed. The main implication concerns the need to implement people’s awareness of the existence of SOEs and the harmful effects they may have on women.
Similarities and differences between SUNCT and SUNA: a cross-sectional, multicentre study of 76 patients in China
Authors: Zhang Shuhua , Cao Ya , Yan Fanhong , Chen Sufen , Gui Wei , Hu Dongmei , Liu Huanxian , Li Hongjin , Yu Rongce , Wei Dan , Wang Xiaolin , Wang Rongfei , Chen Xiaoyan , Zhang Mingjie , Ran Ye , Jia Zhihua , Han Xun , He Mianwang , Liu Jing , Yu Shengyuan , Dong Zhao 
Published: October 2022

Abstract
Background
Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA) have not been evaluated sufficiently due to limited data, particularly in China.

Methods
Patients with SUNCT or SUNA treated in a tertiary headache centre or seven other headache clinics of China between April 2009 and July 2022 were studied; we compared their demographics and clinical phenotypes.

Results
The 45 patients with SUNCT and 31 patients with SUNA had mean ages at onset of 37.22 ± 14.54 years and 42.45 ± 14.72 years, respectively. The mean ages at diagnosis of SUNCT and SUNA were 41.62 ± 12.70 years and 48.68 ± 13.80 years, respectively (p = 0.024). The correct diagnosis of SUNCT or SUNA was made after an average of 2.5 (0–20.5) years or 3.0 (0–20.7) years, respectively. Both diseases had a female predominance (SUNCT: 1.14:1; SUNA: 2.10:1). The two diseases differed in the most common attack site (temporal area in SUNCT, p = 0.017; parietal area in SUNA, p = 0.002). Qualitative descriptions of the attacks included stabbing pain (44.7%), electric-shock-like pain (36.8%), shooting pain (25.0%), and slashing pain (18.4%). Lacrimation was the most common autonomic symptom in both SUNCT and SUNA patients, while eyelid oedema, ptosis, and miosis were less frequent. Triggers such as cold air and face washing were shared by the two diseases, and they were consistently ipsilateral to the attack site.

Conclusions
In contrast to Western countries, SUNCT and SUNA in China have a greater female predominance and an earlier onset. The shared core phenotype of SUNCT and SUNA, despite their partial differences, suggests that they are the same clinical entity.
Central retinal vein occlusion post ChAdOx1 nCoV-19 vaccination – can it be explained by the two-hit hypothesis?
Authors: Parakh Shweta , Maheshwari Shrey , Das Shrutanjoy , Vaish Hans , Luthra Gaurav , Agrawal Rupesh , Gupta Vishali , Luthra Saurabh 
Published: October 2022

Abstract
Purpose
To report a case of central retinal vein occlusion (CRVO) seven days following the first dose of ChAdOx1 nCoV-19 vaccine and propose a hypothesis for the possible underlying pathogenesis.

Observation
A 31-year-old male presented with CRVO with cystoid macular edema, one week after receiving his first ChAdOx1 nCoV-19 vaccine dose. Apart from mild hyperhomocysteinemia, no major thrombophilic or systemic risk factors were found. Anti-platelet factor 4 antibodies, specific for vaccine-induced immune thrombotic thrombocytopenia, were also negative. However, he tested strongly positive (> 250 U/mL) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG spike antibodies, 2 weeks post the first dose – suggestive of a prior subclinical infection.

Conclusion
COVID-19 is known to be associated with an altered host one-carbon metabolism resulting in hyperhomocysteinemia. We hypothesize that a prior subclinical infection with COVID-19, the first hit, may have led to hyperhomocysteinemia in our patient and vaccination must have been the second hit that triggered the thrombotic event. Further studies, including correlation of thrombotic complications with IgG antibody titres post-vaccination, are essential in order to better understand the pathogenesis of such events.
Shrimp miR-965 transfers tumoricidal mitochondria
Authors: Kim Hyueyun , Choi Ji Ha , Moon Chang Mo , Kang Jihee Lee , Woo Minna , Kim Minsuk 
Published: October 2022

Abstract
Background
Micro RNA of Marsupenaeus japonicas has been known to promote apoptosis of tumor cells. However, the detailed mechanisms are not well understood.

Results
Using tomographic microscope, which can detect the internal structure of cells, we observed breast tumor cells following treatment of the miRNA. Intriguingly, we found that mitochondria migrate to an adjacent tumor cells through a tunneling nanotube. To recapitulate this process, we engineered a microfluidic device through which mitochondria were transferred. We show that this mitochondrial transfer process released endonuclease G (Endo G) into tumor cells, which we referred to herein as unsealed mitochondria. Importantly, Endo G depleted mitochondria alone did not have tumoricidal effects. Moreover, unsealed mitochondria had synergistic apoptotic effects with subtoxic dose of doxorubicin thereby mitigating cardiotoxicity.

Conclusions
Together, we show that the mitochondrial transfer through microfluidics can provide potential novel strategies towards tumor cell death.
BoostMEC: predicting CRISPR-Cas9 cleavage efficiency through boosting models
Authors: Zarate Oscar A. , Yang Yiben , Wang Xiaozhong , Wang Ji-Ping 
Published: October 2022

Abstract
Background
In the CRISPR-Cas9 system, the efficiency of genetic modifications has been found to vary depending on the single guide RNA (sgRNA) used. A variety of sgRNA properties have been found to be predictive of CRISPR cleavage efficiency, including the position-specific sequence composition of sgRNAs, global sgRNA sequence properties, and thermodynamic features. While prevalent existing deep learning-based approaches provide competitive prediction accuracy, a more interpretable model is desirable to help understand how different features may contribute to CRISPR-Cas9 cleavage efficiency.

Results
We propose a gradient boosting approach, utilizing LightGBM to develop an integrated tool, BoostMEC (Boosting Model for Efficient CRISPR), for the prediction of wild-type CRISPR-Cas9 editing efficiency. We benchmark BoostMEC against 10 popular models on 13 external datasets and show its competitive performance.

Conclusions
BoostMEC can provide state-of-the-art predictions of CRISPR-Cas9 cleavage efficiency for sgRNA design and selection. Relying on direct and derived sequence features of sgRNA sequences and based on conventional machine learning, BoostMEC maintains an advantage over other state-of-the-art CRISPR efficiency prediction models that are based on deep learning through its ability to produce more interpretable feature insights and predictions.
Impact of neighbourhood-level socioeconomic status, traditional coronary risk factors, and ancestry on age at myocardial infarction onset: A population-based register study
Authors: Kolden Mathias Øie , Nymo Ståle H. , Øie Erik 
Published: October 2022

Abstract
Background
There is consensus that low socioeconomic status (SES) is associated with an increased risk of acute myocardial infarction (AMI), but the extent to which traditional coronary risk factors and other characteristics of low SES mediate this effect remains uncertain. This study examined AMI patients residing in neighbouring city districts with the same local hospital despite having among the most considerable differences in mean SES in Norway. Our purpose was to assess low SES as a coronary risk factor and examine whether traditional coronary risk factors or ancestry mediate this effect.

Methods
Six hundred six patients (215 and 391 with a low and high neighbourhood-level SES, respectively) admitted to Diakonhjemmet Hospital with non-ST-elevation myocardial infarction (NSTEMI) between 2014 and 2017, entered analysis. Data from the Norwegian Myocardial Infarction Register were used to identify patient characteristics, and the STATA/SE 15.1 software was used to perform the statistical analyses.

Results
Patients from socioeconomically disadvantaged city-districts had a 4.9 years earlier onset of AMI (68.99 vs. 73.89 years; p < 0.001) and a higher prevalence of previous AMI, known diabetes, and current smokers (36% vs. 27%, 25% vs. 12%, and 33% vs. 17%, respectively; all p ≤ 0.05). When only comparing patients with a first time AMI, an even greater difference in the age at AMI onset was found (6.1 yrs; p < 0.001). The difference in age at AMI onset remained statistically significant when adjusting for traditional coronary risk factors (3.28 yrs; 95% confidence interval (CI) 1.11−5.44; p = 0.003), but not when adjusting for presumed non-Northwest-European ancestry (1.81 yrs; 95% CI −0.55 to 4.17; p = 0.132).

Conclusion
This study supports earlier research showing an increased risk of AMI in socioeconomically disadvantaged individuals. In our population, presumed non-Northwest-European ancestry could entirely explain the increased risk, whereas traditional coronary risk factors could only partly explain the increased risk.
Atezolizumab plus nab-paclitaxel for unresectable, locally advanced or metastatic breast cancer: real-world results from a single academic center in Austria
Authors: Deutschmann Christine , Bartsch Rupert , Singer Christian F , Gschwantler-Kaulich Daphne , Seifert Michael , Leser Carmen , Marhold Maximilian , Bago-Horvath Zsuzsanna , Pfeiler Georg 
Published: October 2022

Abstract
Purpose
IMpassion130 led to the approval of atezolizumab plus nab-paclitaxel as first-line treatment for patients with unresectable locally advanced or metastatic triple-negative, PD-L1 immune-cell positive breast cancer (BC) by the European Medicines Agency (EMA). The objective of the present study was to investigate the implementation, safety and efficacy of this combination in the initial phase after approval.

Methods
A retrospective data analysis including all BC patients who received atezolizumab and nab-paclitaxel between 1.1.2019 and 31.10.2020 at the Department of Obstetrics and Gynecology and the Department of Medicine 1, respectively, at the Medical University of Vienna, Austria, was performed. Progression-free survival (PFS) and overall survival (OS) were estimated with the Kaplan-Maier product-limit method. Owing to the retrospective nature of this study, all statistics must be considered exploratory.

Results
In total 20 patients were included in the study. Median follow-up was 7.1 months (IQR 5.2–9.1). Median PFS was 3.0 months (SE = .24; 95% CI [2.5; 3.5]). Median OS was 8.94 months (SE = 2.34, 95%CI [4.35; 13.53]). No new safety signals were observed.

Conclusion
The present study showed a considerably shorter PFS (3.0 vs. 7.5 months) and OS (8.94 vs. 25.0 months) than IMpassion130 putatively owing to the use of atezolizumab in later treatment lines, more aggressive tumors and a study population with higher morbidity compared to the pivotal trial.
Measurement of hearing impairment among Greenlandic school-children: association between self-reported data and clinical examinations
Authors: Schnohr Christina , Jensen Jakob Schmidt , Skovsen Cecilie Friis , Homøe Preben , Niclasen Birgit , Jensen Ramon Gordon 
Published: October 2022

Abstract
Background
Multiple ear infections is causing hearing impairment among children all over the world and the health and social consequences track into early adolescence and later in life, if not treated. The monitoring of prevalence in a population is important to assess the need for interventions in a population.

Methods
One hundred eighty five children from 5 to 10th grade from Sisimiut town and the nearby settlements participated in a clinical examination to have ear-examination and pure tone audiometry. Participants filled out a questionnaire at home with their parents before the clinical examination, and hearing impairment was collected as individual self-reports and as audiometric measurements.

Results
A total of 185 children between 9 and 15 years of age (median: 11 years, IQR: 10–13) were included, 60% (n = 111) were girls. 247 (70%) of the 355 available otoscopies were clinically assessed as normal. Cohen’s Kappa coefficient was 0.31. Eighteen children (10%) were found to have hearing impairment. None of the children had hearing aids. Test performance for self-reports were that sensitivity was 56% and specificity was 87%. The predictive value of a positive test was 31%, and the predictive value of a negative test was 95%. 32 children (17%) reported hearing impairment to the extent that they were not able to keep up in school, of which half reported that it had lasted for more than one year. 7 of the 32 children reporting hearing impairment (22%) reported that the extent of their hearing impairment was affecting their classroom experience so they were not able to follow.

Conclusion
Self-reported and clinically screening for hearing impairment are two different concepts. Even though the two concepts are statistically correlated, the correlation coefficients are low. The test performance indicated that self-reported data might be measuring hearing as an experience in a social environment and not directly comparable to pure tone audiometry which examines hearing in controlled testing conditions. Since both measure hearing impairment, they supplement each other in research on impaired hearing, and the choice of measure should relate to the purpose and method of the investigation.
Inverse association between Helicobacter pylori infection and childhood asthma in a physical examination population: a cross-sectional study in Chongqing, China
Authors: Wang Donghai , Chen Yuxia , Ding Yuan , Tu Jinwei 
Published: October 2022

Abstract
Background
Childhood asthma has substantial effects on children's health. It is important to identify factors in early life that influence childhood asthma. Accumulating evidence indicates that Helicobacter pylori may protect against allergic diseases. This study aimed to evaluate the relationship between H. pylori infection and pediatric asthma in Chongqing, China.

Materials and methods
This cross-sectional study included healthy children aged 4–18 years who underwent a 13C urea breath test during medical checkups in 2021. All medical information was extracted from electronic medical records and a big data system. Logistic regression was used to evaluate the association between H. pylori infection and pediatric asthma, and multivariate regression models were adjusted for covariates.

Results
In our study, 2241 participants, including 1240 boys (55.33%) and 1001 girls (44.67%), underwent urea breath testing (average age: 8.67 ± 2.70 years). Among them, 292 (13.03%) were positive for H. pylori and 152 (6.78%) had asthma. The rates of asthma diagnosis in H. pylori-negative and -positive children were 7.23% and 3.77%, respectively (odds ratio = 1.995; 95% confidence interval: 1.003–3.968; P < .05). Furthermore, family history of asthma and the percentage of eosinophils in routine blood examination were associated with childhood asthma; however, the body mass index, platelet count, and serum vitamin D level were not.

Conclusions
We demonstrated a significant inverse association between H. pylori infection and pediatric asthma in Chongqing, China. Further studies are required to determine the causal association and underlying mechanisms to prevent and control childhood asthma.
The processes involved in the establishment of user-provider partnerships in severe psychiatric illnesses: a scoping review
Authors: Boerkoel Aletta , Brommels Mats 
Published: October 2022

Abstract
Purpose
With the rising relevance of person-centred care, initiatives towards user-led decision making and designing of care services have become more frequent. This designing of care services can be done in partnership, but it is unclear how. The aim of this scoping review was to identify for mental health services, what user-provider partnerships are, how they arise in practice and what can facilitate or hinder them.

Methods
A scoping review was conducted to obtain a broad overview of user provider partnerships in severe mental illness. Data was inductively analysed using a conventional content analysis approach, in which meaning was found in the texts.

Results
In total, 1559 titles were screened for the eligibility criteria and the resulting 22 papers found relevant were analysed using conventional content analysis. The identified papers had broad and differing concepts for user-provider partnerships. Papers considered shared decision making and user-involvement as partnerships. Mechanisms such as open communication, organisational top-down support and active participation supported partnerships, but professional identity, power imbalances and stress hindered them. Users can be impeded by their illness, but how to deal with these situations should be formalised through contracts.

Conclusion
The field of research around user-provider partnerships is scattered and lacks consensus on terminology. A power imbalance between a user and a provider is characteristic of partnerships in mental healthcare, which hinders the necessary relationship building allowing partnerships to arise. This power imbalance seems to be closely linked to professional identity, which was found to be difficult to change.