bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protocol of safe vaccination against COVID‐19 in patients with high risk of allergic reactions
Authors: Romantowski Jan , Kruszewski Jerzy , Solarski Oskar , Bant Andrzej , Chciałowski Andrzej , Pietrzyk Ilona , Sańpruch Patrycja , Górska Aleksandra , Chełmińska Marta , Knurowska Agata , Gawinowska Marika , Jassem Ewa , Niedoszytko Marek 
Published: May 2022

AbstractBackgroundSars‐CoV‐2 infections are hazardous, especially to the elderly and patients with comorbidities. With no efficient treatment available, newly developed vaccines are the only way to change the course of the pandemic. However, reports of allergic reactions resulted in some patients and practicing physicians being concerned about the safety of vaccine administration, particularly in people with severe anaphylactic reactions to multiple or unknown factors in their medical history.This study aimed to develop an allergic work‐up protocol based on skin prick tests (SPT), intradermal testing (IDT) and intramuscular provocations, and desensitisation which may contribute to diagnosis and management of anti‐COVID‐19 vaccine allergy.MethodsTwo hundred and eighty‐five patients were enrolled. Two hundred and five of them entered the study based on severe anaphylactic reaction to unknown or multiple factors in their medical history which disqualified them for standard treatment. Another 80 patients were enrolled after developing an allergic reaction to the first dose of one such vaccine. In all subjects, SPT and IDT were performed. Serum tryptase was assessed in 79 patients randomly chosen from the study group.ResultsTwo hundred and seventy‐seven patients with negative tests were given a vaccine without complications. Seven patients had positive skin tests. In two cases, tests confirmed Comirnaty allergy, while the other five confirmed solely skin sensitisation with no exposure prior to the study. Six patients with positive tests received titrated challenge using desensitisation protocol with a reasonable tolerance. One patient did not consent to desensitisation and one patient resigned despite negative tests. Overall, 283 (99%) patients were vaccinated using this newly developed protocol. Patients with adverse reactions to the first dose of the vaccine before the study had a significantly lower basal serum tryptase concentration (p = 0.001).ConclusionSkin tests with anti‐COVID‐19 vaccines are a useful tool in the vaccination protocol. This protocol enables safe immunisation of high‐allergy‐risk patients even in cases of positive skin tests.
Macroscale connections of the mouse lateral preoptic area and anterior lateral hypothalamic area
Authors: Hahn Joel D. , Gao Lei , Boesen Tyler , Gou Lin , Hintiryan Houri , Dong Hong‐Wei 
Published: May 2022

AbstractThe macroscale neuronal connections of the lateral preoptic area (LPO) and the caudally adjacent lateral hypothalamic area anterior region (LHAa) were investigated in mice by anterograde and retrograde axonal tracing. Both hypothalamic regions are highly and diversely connected, with connections to >200 gray matter regions spanning the forebrain, midbrain, and rhombicbrain. Intrahypothalamic connections predominate, followed by connections with the cerebral cortex and cerebral nuclei. A similar overall pattern of LPO and LHAa connections contrasts with substantial differences between their input and output connections. Strongest connections include outputs to the lateral habenula, medial septal and diagonal band nuclei, and inputs from rostral and caudal lateral septal nuclei; however, numerous additional robust connections were also observed. The results are discussed in relation to a current model for the mammalian forebrain network that associates LPO and LHAa with a range of functional roles, including reward prediction, innate survival behaviors (including integrated somatomotor and physiological control), and affect. The present data suggest a broad and intricate role for LPO and LHAa in behavioral control, similar in that regard to previously investigated LHA regions, contributing to the finely tuned sensory‐motor integration that is necessary for behavioral guidance supporting survival and reproduction.
Oral care tablet containing kiwifruit powder affects tongue coating microbiome
Authors: Fukui Makoto , Asakuma Hiroki , Horiuchi Hiroko , Takii Hiroshi , Yoshioka Masami , Hinode Daisuke 
Published: May 2022

AbstractObjectivesTongue coating, a kind of biofilm formed on the tongue dorsum, is the cause of various clinical conditions, such as oral halitosis and periodontal diseases, because Fusobacterium nucleatum acts as a bridge between other oral bacteria and periodontopathogenic bacteria in biofilm formation. Our previous clinical study revealed that taking oral care tablets containing kiwifruit powder significantly reduced not only tongue‐coating index and volatile sulfur compounds but also total bacteria and F. nucleatum in tongue coating. In this study, we analyzed the microbiome of tongue coating samples obtained before and after oral care tablets intake to clarify whether this tablet is a useful tool for daily tongue care.MethodsThirty‐two healthy young adults were enrolled, and a crossover clinical trial was conducted. We instructed subjects to remove tongue coating by tongue brush for intervention I, to keep the oral care tablet containing kiwifruit powder on the tongue dorsum and to let it dissolve naturally for intervention II. Microbial DNA was isolated from the collected tongue coating samples in each subject, then 16S rRNA next‐generation sequencing, operational taxonomic unit clustering, and statistical analysis were performed.ResultsThe microbiome analysis revealed that the oral care tablet in intervention II prompted a significant change in the tongue microbiota composition, a significant reduction in the relative abundance of Prevotella and Porphyromonas, and an increase in Firmicutes/Bacteroidetes ratio when compared to that in intervention I.ConclusionThese results suggested that the oral care tablet might contribute to the improvement of the oral condition due to its good influence on the tongue coating microbiome.
Gebäude‐Ökobilanzen im Wandel der Zeit
Authors: Nisse Juliane , Holm Andreas 
Published: May 2022

AbstractDas Bauen heute ist geprägt von einer Vielzahl von Anforderungen, Nachweisen und Pflichten. Während noch bis vor kurzer Zeit v. a. statische und bauphysikalische Anforderungen an Gebäude formuliert wurden, werden in zunehmendem Maße Anforderungen zur Begrenzung von CO2‐Emissionen oder zur Reduzierung der grauen Energie gestellt, welche klimapolitisch eine immer größere Rolle spielen. Mit der Einführung des 1. Leitfadens für Nachhaltiges Bauen im Jahr 2001 war das nachhaltige Bauen eine Königsdisziplin und konnte über entsprechende Nachhaltigkeitszertifikate den Wert einer nachhaltigen Immobilie steigern. Heute wird Nachhaltigkeit von Gebäuden zunehmend als Standard angesehen und in Zukunft über Gesetze und/oder Verordnungen auch als ein solcher eingefordert werden. Wie sich der Stellenwert des nachhaltigen und v. a. des ökologischen Bauens sowie die Qualität der Ökobilanzdaten für Bauprodukte ebenso wie die Bewertungs‐ und Bilanzierungsmethodik für die Ökobilanzierung im Laufe der Zeit verändert haben, wird in diesem Aufsatz näher erörtert.
Roadmap für eine treibhausgasneutrale Porenbetonindustrie in Europa
Authors: Kreft Oliver , Fudge Cliff , Walczak Paweł 
Published: May 2022

AbstractDer Gebäude‐ und Bausektor ist für einen erheblichen Teil der europäischen Treibhausgasemissionen verantwortlich. Diese Roadmap beschreibt, wie die europäische Porenbetonindustrie bis zum Jahr 2050 klimaneutral werden kann. Mit seiner Eigenschaft, als CO2‐Senke zu fungieren, hat Porenbeton – über Klimaneutralität hinaus – das Potenzial, CO2‐negativ zu werden. Das bedeutet, dass dieser Baustoff in seinem Lebenszyklus der Atmosphäre mehr Kohlenstoff entzieht, als bei Herstellung, Transport, Nutzung und Nachnutzung freigesetzt wurde. Die Szenarioentwicklung für das Jahr 2050 erfolgte auf Basis technischer Maßnahmen zur Effizienzoptimierung, der Umstellung von fossilen auf erneuerbare Energieträger sowie einer aktuellen Lebenszyklusanalyse für ein repräsentatives Porenbetonprodukt. Der überwiegende Anteil der CO2‐Emissionen im Lebenszyklus von Porenbeton entsteht nicht in der Produktion von Porenbeton selbst, sondern bei der Herstellung der Ausgangsstoffe Zement und Kalk. Aus diesem Grund orientiert sich die vorliegende Roadmap eng an den Dekarbonisierungspfaden europäischer Herstellerverbände der Zement‐ und Kalkindustrie. Mit dieser Roadmap verpflichten sich der Europäische Porenbetonverband (European Autoclaved Aerated Concrete Association, EAACA) und seine Mitglieder zur Erreichung der CO2‐Neutralität ihrer Produkte und zur Unterstützung bei der Verwirklichung eines klimaneutralen Europas.
Eating disorders and the nine symptoms of borderline personality disorder: A systematic review and series of meta‐analyses
Authors: Miller Alexia E. , Trolio Vittoria , Halicki‐Asakawa Amané , Racine Sarah E. 
Published: May 2022

AbstractObjectiveEating disorders and borderline personality disorder have high rates of comorbidity. However, the extent to which individual BPD symptoms are elevated in patients with EDs is largely unknown. Meta‐analyses examined: (1) which of the nine BPD symptoms are especially elevated in individuals with versus without EDs, (2) whether particular ED subtypes have elevated levels of certain BPD symptoms, and (3) which BPD symptoms remain unstudied/understudied in relation to EDs.MethodsWe performed nine separate meta‐analyses (one for each BPD symptom) to compare levels of symptoms in patients with EDs versus healthy controls. A total of 122 studies (range = 4–34 studies across symptoms) were included.ResultsAffective instability was the BPD symptom most elevated, while anger was the BPD symptom least elevated, in patients with EDs compared to controls. When comparing effect sizes across ED subtypes, anorexia nervosa binge‐eating/purging subtype had the largest effect sizes for the greatest number of BPD symptoms, while effect sizes for AN restrictive subtype were not significantly larger than those of other EDs for any BPD symptom. The least studied BPD symptoms were identity disturbance and interpersonal difficulties.DiscussionThese meta‐analyses suggest that certain symptoms of BPD play a more prominent role in the comorbidity between BPD and EDs than others. Targeting affective instability when treating cases of comorbid ED and BPD may be especially likely to ameliorate the negative outcomes related to this comorbidity. Future research should further investigate identity disturbance and interpersonal difficulties in the context of EDs.Public SignificanceHaving an eating disorder and borderline personality disorder is a common comorbidity associated with a severe clinical presentation. BPD is characterized by nine distinct symptoms. This research examined levels of individual BPD symptoms in patients with versus without EDs. Findings can guide researchers and clinicians towards studying and treating symptoms that may be most relevant for BPD‐ED comorbidity and in turn, improve outcomes for these patients.
Home is where the hollow is: Revealing vertebrate tree hollow user biodiversity with eDNA metabarcoding
Authors: Newton Joshua P. , Bateman Philip W. , Heydenrych Matthew J. , Mousavi‐Derazmahalleh Mahsa , Nevill Paul 
Published: May 2022

AbstractTree hollows are essential for many vertebrate species, providing both nesting sites and shelter. Globally, old hollow‐bearing trees are in decline resulting in many dependent species being under threat. It is, therefore, imperative that vital hollow‐bearing trees are preserved, but it is logistically difficult to rapidly determine which hollows are being used and by which taxa. Here, we investigate the efficacy of eDNA metabarcoding as a survey tool for vertebrate hollow users. We compared the identity and richness of hollow‐inhabiting vertebrate taxa using eDNA metabarcoding of both sediment from the tree hollows, and material collected using roller swabs. Samples (n = 138) were collected from hollow‐bearing tuart trees (Eucalyptus gomphocephala; N = 28), within both an urban remnant and a relatively undisturbed forested area of South‐West Western Australia. We detected a wide range of vertebrate taxa, including cryptic species such as the brush‐tailed phascogale (Phascogale tapoatafa), while also providing ecologically informative data, such as hollow use by invasive Rainbow Lorikeet (Trichoglossus moluccanus) within the study areas. Our results showed variation in the species detected between methods, with the roller swab method detecting a greater number of species and a higher mean species richness per sample than hollow sediment did. The species detected from both methods did not perfectly overlap, highlighting the value of using multiple methods or substrates to detect a greater number of taxa. Our results suggest eDNA metabarcoding from tree hollow samples offers a sensitive and resource‐efficient method of monitoring vertebrate hollow users, if enough hollows are sampled. This provides not only a broad biodiversity assessment tool, but also an effective method for detecting taxa that may be elusive using other methods.
Intravenous iron supplement for iron deficiency in patients with severe aortic stenosis scheduled for transcatheter aortic valve implantation: results of the IIISAS randomised trial
Authors: Kvaslerud Anette B. , Bardan Sara , Andresen Kristoffer , Kløve Sophie F. , Fagerland Morten W. , Edvardsen Thor , Gullestad Lars , Broch Kaspar 
Published: May 2022

AimsThe aim of this trial was to evaluate whether intravenous iron could provide benefit beyond transcatheter aortic valve implantation (TAVI) in iron‐deficient patients with severe aortic stenosis.Methods and resultsIn this randomised, placebo‐controlled, double‐blind, single‐centre trial, we enrolled patients with severe aortic stenosis and iron deficiency (defined as ferritin <100 µg/L, or 100–299 µg/L with a transferrin saturation <20%) who were evaluated for TAVI. Patients were randomly assigned (1:1) to receive intravenous ferric derisomaltose or placebo ∼3 months before TAVI. The primary endpoint was the between‐group, baseline‐adjusted 6‐min walk distance measured 3 months after TAVI. Secondary outcomes included quality of life, iron stores, hand grip strength, New York Heart Association (NYHA) class, and safety. Between January 2020 and September 2021, we randomised 74 patients to ferric derisomaltose and 75 patients to placebo. The modified intention‐to‐treat population comprised the 104 patients who completed the 6‐min walk test at baseline and 3 months after successful TAVI. Iron stores were restored in 76% of the patients allocated to iron and 13% of the patients allocated to placebo (p < 0.001). There was no difference in the baseline‐adjusted 6‐min walk distance between the two treatment arms (p = 0.82). The number of serious adverse events, quality of life, hand grip strength, and NYHA class did not differ between the treatment arms.ConclusionTreatment with intravenous iron did not provide clinical benefit beyond TAVI in iron‐deficient patients with severe aortic stenosis.Clinical Trial Registration: ClinicalTrials.gov NCT04206228.
An investigation comprising the effect of soda and bleaching sequences on suitability of sorghum bagasse as an alternative fiber in papermaking
Authors: Said Abd El Aziz A. , Aly Aref A. M. , Mustafa Atef H. , Ahmed Hazem S. 
Published: May 2022

AbstractThe aim of this work is to evaluate the potency of sorghum stalks as an alternative fiber for pulp and papermaking for the first time in Egypt. Sorghum Kraft pulp was bleached using D0EOD1 sequences to achieve a final high brightness and suitable mechanical strength. The results revealed that pulping alkali of 14% Na2O concentration is the best choice. In addition, this percentage preserved high pulp brightness with a value of 86 ISO together with low fiber degradation besides imparting a high mechanical strength to the product. So, sorghum bagasse can be utilized as an important available low‐cost non‐wood fiber for paper industry.
Ultralow loading FeCoNi alloy nanoparticles decorated carbon mat for hydrogen peroxide reduction reaction and its application in direct ethylene glycol fuel cells
Authors: Pan Zhefei , Zhang Zhewei , Tahir Abdullah , Esan Oladapo Christopher , Liu Xinhua , Wang Huizhi , An Liang 
Published: May 2022

SummaryHydrogen peroxide has been an attractive oxidant in direct liquid fuel cells. However, hydrogen peroxide reduction reaction heavily relies on noble metal‐based electrocatalysts. In this work, a carbon mat decorated with FeCoNi alloy nanoparticles (namely FeCoNi/CM) of an ultralow loading, that is, 0.146 mg cm−2, for hydrogen peroxide reduction is designed, fabricated, and applied as a free‐standing cathode in a passive alkaline‐acid direct ethylene glycol fuel cell. A piece of Pd/C coated carbon cloth (1.0 mg cm−2) is used as the anode and a pre‐treated Nafion 211 membrane as the membrane. This passive fuel cell yields a peak power density of 17.4 mW cm−2 at 23°C, which is comparable to an Au/C‐based cathode (17.0 mW cm−2). The new electrode shows significantly enhanced mass transfer and allows a current density of 60.0 mA cm−2, which is 1.5 times the value achieved with the Au/C‐based cathode. This can be attributed to the much thinner thickness of FeCoNi/CM (50.0 μm) than Au/C‐based cathode (380.0 μm). With the thinner thickness, the oxygen derived from the self‐decomposition of hydrogen peroxide can be effectively removed from the cathode, which is beneficial for the transport of hydrogen peroxide to the catalyst surface. Moreover, with the use of this free‐standing cathode, the passive fuel cell attains a continuous operation at a constant discharging current of 20.0 mA for more than 9 h, exceeding the 5 h achieved with the Au/C‐based cathode at the same discharging current density.
Structural, optical, electrical, and DFT studies on polyvinyl pyrrolidone/polyethylene oxide polymer blend filled with MoO3 nanoplates for flexible energy‐storage devices
Authors: Al‐Muntaser A.A. , AlSaidi Ramadhan A. M. , Sharma Kamal , Alamri Hatem R. , Makhlouf M.M. 
Published: May 2022

SummaryNanocomposite films of PVP/PEO containing MoO3 nanoplates were prepared using a casting procedure. XRD results showed that the addition of MoO3 in the virgin PVP/PEO blend increases the amorphous domains of polymer nanocomposite (PNC) films. The DFT/FT‐IR results have established the miscibility and the interaction between PVP and PEO polymers via hydrogen bonds. Also, FTIR studies showed a coordination interaction between MoO3 nanoplates and the C=O group of PVP and/or the C‐O‐C group of PEO of the PVP/PEO blend. The optical band gap values of PNC films of PVP/PEO/MoO3 decreased with increasing MoO3 content. The relaxation processes and dielectric dispersion of the prepared PNC films were examined and discussed. The electrical conductivity was enhanced via the addition of MoO3 nanoplates because of an increase in the number density of the charge carriers. The dominated conduction mechanism of PNC films reveals the correlated barrier hopping model, while the type of relaxation process follows the non‐Debye one. These observations illustrate the applicability and potential uses of these PNC films as a nanodielectric material in ceramic capacitors and electrochemical applications such as devices of energy storage and separators in batteries.
An ultra‐short‐term wind speed prediction model using LSTM based on modified tuna swarm optimization and successive variational mode decomposition
Authors: Tuerxun Wumaier , Xu Chang , Guo Hongyu , Guo Lei , Zeng Namei , Cheng Zhiming 
Published: May 2022

AbstractAccurate ultra‐short‐term wind speed prediction is extremely important for the power control of wind farms, the safe dispatch of power systems, and the stable operation of power grids. At present, most wind farms mainly rely on supervisory control and data acquisition systems to obtain operation and maintenance data which includes operating characteristics of wind turbines. In the ultra‐short‐term wind speed prediction, a long short‐term memory network is one of the commonly used deep learning methods. To address the problem that improper selection of long short‐term memory network's hyperparameters may affect the prediction results, In the present study, a hybrid prediction model based on the long short‐term memory and the modified tuna swarm optimization algorithm was established, and was used to predict after the wind speed sample data had been decomposed by successive variational mode decomposition method. The experimental results reveal that the proposed model effectively improved the accuracy of wind speed prediction for wind farms compared with the support vector regression, deep belief networks, and long short‐term memory models optimized by particle swarm optimization algorithm.
Avermectin Toxicity to Benthic Invertebrates is Modified by Sediment Organic Carbon and Chemical Residence Time
Authors: Jacova Ruben , Kennedy Christopher 
Published: May 2022

Abstract
Chemicals used in sea lice management strategies in salmonid aquaculture include the avermectin class of compounds that can accumulate and persist in the sediments underneath salmon farms and directly impact nontarget benthic fauna. The effects of sediment organic carbon content and chemical residence time (CRT) on the lethal and sublethal toxicity of emamectin benzoate (EB; formulation: Slice®) and ivermectin (purified) and a combination of both were examined in two benthic invertebrates, the amphipod Eohaustorius estuarius and the polychaete Neanthes virens. In both species, increased sediment organic carbon content significantly reduced lethal toxicity, a modulation that was more pronounced for ivermectin and combination exposures. At a CRT of 4 months, lethal toxicity was reduced in E. estuarius but was unaffected in N. virens. Sublethal toxicity in N. virens (burrowing behavior) was modulated by sediment organic carbon and CRT in a similar manner to the trend in lethal toxicity. Inconsistencies in behavior (phototaxis) in E. estuarius made conclusions regarding toxicity modification by sediment organic carbon or CRT inconclusive. Our results indicate that environmental factors including sediment organic carbon content and the time compounds reside in sediments are important modifiers of chemotherapeutant toxicity in nontarget benthic species and should be considered when regulatory decisions regarding their use are made. Environ Toxicol Chem 2022;41:1918–1936. © 2022 SETAC
Simultaneous detection of viable Salmonella spp., Escherichia coli, and Staphylococcus aureus in bird's nest, donkey‐hide gelatin, and wolfberry using PMA with multiplex real‐time quantitative PCR
Authors: Liang Taobo , Long Hui , Zhan Zhongxu , Zhu Yingfei , Kuang Peilin , Mo Ni , Wang Yuping , Cui Shenghui , Wu Xin 
Published: May 2022

AbstractSalmonella spp., Escherichia coli, and Staphylococcus aureus are common microbial contaminants within the homology of medicine and food that can cause serious food poisoning. This study describes a highly efficient, sensitive, specific, and simple multiplex real‐time quantitative PCR (mRT‐qPCR) method for the simultaneous detection of viable Salmonella spp., E. coli, and S. aureus. Primers and probes were designed for the amplification of the target genes invA, uidA, and nuc. Dead bacterial genetic material was excluded by propidium monoazide (PMA) treatment, facilitating the detection of only viable bacteria. This method was capable of detecting Salmonella spp., E. coli, and S. aureus at 102, 102, and 101 CFU/ml, respectively, in pure culture. PMA combined with mRT‐qPCR can reliably distinguish between dead and viable bacteria with recovery rates from 95.7% to 105.6%. This PMA‐mRT‐qPCR technique is a highly sensitive and specific method for the simultaneous detection of three pathogens within the homology of medicine and food.