bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemic BCG administration stimulates NK and T cell-mediated antitumor lung immunity and overcomes tumor resistance to immune checkpoint inhibition
Authors: AGUILO NACHO , Moreo Eduardo , Robles Iñaqui , Guerrero Claudia , Jarit Aitor , Felgueres María José , Esteso Gloria , Uranga-Murillo Iratxe , Uranga Santiago , Gomez Ana Belen , Pardo Julian , Martin Carlos , Vales-Gomez Mar , Fresno Carlos del , Sancho David 
Published: October 2022

Abstract
Intravesical administration of BCG was the first immunotherapy approved by the FDA and it is still nowadays the treatment of choice for a subset of non-muscle invasive bladder cancer patients. Considering this precedent and the strong capabilities of BCG to trigger cellular responses, we hypothesized that systemic administration of BCG by the intravenous route (IV BCG), a vaccination strategy that has been found well-tolerated, highly immunogenic and effective at preventing tuberculosis infection in non-human primates, could result effective against lung tumors. Our data revealed that IV BCG, administered in a therapeutic scenario, slowed tumor growth and extended mouse survival in models of B16-F10 lung metastasis and in an orthotopic LLC lung cancer model, by enhancing both antitumoral innate and adaptive immune responses. IV BCG administration induced tumor-specific CD8+ T cell responses with enhanced cytotoxic function, in a process dependent on conventional type 1 Dendritic Cells (cDC1s). In addition, we found that BCG strongly activated both human and mouse NK cells. Remarkably, NK cell depletion prevented BCG-induced cDC1 recruitment to the tumor-bearing lung and reduced cDC1 upload with tumor-derived antigens, as well as the subsequent induction of tumor-specific CD8+ T cell responses and tumor control. Of note, IV BCG strongly synergized with the immune checkpoint inhibitor (ICI) anti-PD-L1 in lung tumors which were otherwise resistant to immune checkpoint blockade given as monotherapy, suggesting the IV BCG could represent a promising ICI-resensitizing cancer immunotherapy.
Predicting Choice Behaviour in Economic Games using Gaze Data Encoded as Scanpath Images
Authors: Byrne Sean Anthony , Reynolds Adam Peter Frederick , Biliotti Carolina , Bargagli-Stoffi Falco , Polonio Luca , Riccaboni Massimo 
Published: October 2022

Abstract
Eye movement data has been extensively utilized by researchers interested in studying decision-making within the strategic setting of economic games. In this paper, we demonstrate both a deep learning and traditional machine learning classification method which are able to accurately identify a given participant's decision strategy before they commit to an action while playing games. Our approach focuses on creating scanpath images that best capture the dynamics of a participant's gaze behaviour during a given game in a way that is meaningful to the machine learning models. Our results demonstrate a higher classification accuracy compared to traditional methods of analysis applied to the same economic game environments by as much as 18 percentage points. In a broader context, we aim to illustrate the potential for eye-tracking data to create information asymmetries in strategic environments in favour of those who collect and process the data. These information asymmetries could become especially relevant as eye-tracking is expected to become more widespread in user applications, with the seemingly imminent mass adoption of virtual reality systems, and the development of devices with the ability to record eye movement outside of a laboratory setting.
A low computation detection method of signal nonlinear distortion based on digital quadrature detection principle
Authors: WANG Pengcheng , Huang Xiaoping 
Published: October 2022

Abstract
This paper presents a digital low computation detection method for signal nonlinear distortion. After presetting ADC sampling rate and completing data sampling, the low sampling rate data extracted from the sampling data completes the autocorrelation analysis to correct and calculate the accurate fundamental frequency. According to the relationship between the fundamental frequency and the sampling rate, the complete periodic segment data of the signal cutting out from the sampling data carries out the digital orthogonal detection operation to obtain the value of each harmonic component and nonlinear distortion. Experiments show that the calculation of this method is less than that of FFT spectrum analysis method when measuring the THD lower than 15 order. When calculating the 15 order THD at 1024 points, the calculation time is reduced by 44.26%. Moreover, the digital quadrature detection method has high measurement accuracy with less than 0.6% error of detecting 5th order THD.
Use of Noise Prediction Models for Road Noise Mapping in Locations That Do Not Have a Standardized Model: a Systematic Review
Authors: Meller Gabriela , de Lourenço Willian Magalhães , de Melo Viviane Suzey Gomes , Grigoletti Giane de Campos 
Published: October 2022

Abstract
Faced with the accelerated growth of cities and the consequent increase in the number of motor vehicles, urban noise levels, caused by vehicular traffic, have increased considerably. In order to assess noise levels in cities and to successfully implement noise control measures or to identify the location of the problem in different urban areas, it is first necessary to obtain information on the noise levels to which people are exposed. Noise maps are tools that have several potential applications as they are cartographic representations of the noise level distribution in area and over a period of time. This article aims to identify, select, evaluate and synthesize information, through a Systematic Literature Review, on the use of different road noise prediction models, in sound mapping computer programs in countries that do not have a standard noise prediction model. From a previous analysis of articles, the choice of topic was based on the identification of a variety of different models for predicting road noise in countries that do not have a standardized model for the use of sound mapping. The papers compiled by SLR showed that studies concentrated in China, Brazil and Ecuador, and that the most used traffic noise prediction models were the RLS-90 and the NMPB, and the most used mapping programs were SoundPLAN and ArcGIS with a grid size of 10 x 10 m. Most measurements were carried out during a 15 min period at a height from ground level of 1.5 m.
Recovery journey of schizophrenic patients in Chinese culture:A Qualitative Study of Experiences
Authors: Ma Min , Shi Zhidao , Chen Yanhong , Ma Xiquan 
Published: October 2022

Abstract
Background: Psychiatric recovery is an integration of clinical and psychosocial frameworks. Previous concepts of recovery have been derived from a Western individualistic cultural context. In contrast, Chinese culture is dominated by collectivism under Confucianism. Therefore the recovery journey of Chinese people with schizophrenia may differ from that of the West. This study examines the experiences of Chinese schizophrenics on their recovery journey to understand the impact of Chinese culture on recovery.
Methods: The researcher selected 11 schizophrenic patients for an in-depth interview. And the researcher used an interpretative phenomenological research method to analyze the data.
Results: Three themes were identified in this study: traumatic experiences, rooted in family, and recovery impetus, comprising nine sub-themes. "Responsibility to the family" and "relying on oneself" are the main drivers of recovery for patients with a Chinese cultural background. Some patients believe that taking care of themselves is an important way to ease the burden on their families and treat them well. So there is a link between 'responsibility to family' and 'reliance on oneself.
Conclusions: Chinese patients with schizophrenia experience significant traumatic experiences and profoundly interact with their families. Both patient autonomy and kinship contribute to the recovery journey, suggesting that the influence of both patient autonomy and kinship should be considered in services that promote recovery. Developing a Chinese cultural context for recovery is an essential issue for Chinese psychiatric rehabilitation services.
Using Big Data and Orthogonal Matching Pursuit Regression for Forecasting Worldwide Green House Gasses Emissions and Consumption
Authors: Malakouti Seyed matin 
Published: October 2022

Abstract
According to the World Resources Institute, the quantity of carbon dioxide generated per person is rising. Low levels of carbon dioxide gas are safe for humans to breathe, but long-term exposure to the gas has been associated with several health issues. On the other hand, this gas may impact the respiratory system if the concentration is high enough. Additionally, the neurological system is in danger. Carbon dioxide, a greenhouse gas, has many potential uses. On the other hand, if the pace of output in industrial units is not managed, it might lead to severe issues and high compensation costs. This study creates a machine learning model that can generate the high accuracy in the shortest period to calculate the Emissions of greenhouse gases produced globally per capita.
Profile of Positive Specific Immunoglobulin E to Aeroallergen among Sudanese Patients at Al-Rayan Laboratory from January 2019 to December 2020
Authors: Mohamedahmed Mohamed Hassan Osman , Salih Omaima Abdelmajeed Mohammed , Mustafa Alamin , Mohammed Hala Hamza Eltayeb , Hassan Malaz Elsadeg , Ahmed Rogaia Hasap Alrasoul 
Published: October 2022

Abstract
Introduction:
Aeroallergens are various airborne substances or inhalants, such as pollen, spores, and other biological or non-biological airborne particles that can cause allergic disorders. Inhalation or cutaneous contact with aeroallergens can trigger a release of proteins in the form of an allergic reaction on the skin and mucous membranes.
Methods: This study was a qualitative retrospective study conducted in the Al-Rayan lab in Khartoum state from January 2019 to December 2020. All records with positive specific IgE to aeroallergens have been collected from Al Rayan Laboratory center. The immunoblotting technique [Euroline food gulf (IgE)] detect the IgE antibody against specific aeroallergens
Result:. Ninety-nine participants were positive for the specific IgE test aeroallergens panel. Most of them were adults, and the mean age of the participants was 21.3 ± 16.3. The most prevalent aeroallergen was Timothy grass and Oak. Timothy grass was positive among (46.5%) of the patients, Cultivated rye, olive tree, and common ragweed were mainly positive in November. The test for Oak allergen came positive in November 2020, March 2020, and October 2019 with the respective percentages (64.3%, 85.7%,46.2%). The olive tree and common ragweed aeroallergen reactions came equally positive in November 2020 the most (57.1%). Moreover, the age of the participants was related to Dog and Horse aeroallergens. In addition to penicillium, children mainly tested positive for Dog, Horse aeroallergens at P values (< 0.05).
Conclusion:
This study demonstrates that the most common aeroallergens are Timothy grass and Oak, followed by cultivated rye.
Virtual reality intervention for psychotic disorders using 360-degree video - agile development of an easy to implement protocol
Authors: Mikkonen Kasperi , Salmijärvi Laura , Lindgren Maija , Kröger Heta , Karpov Boris , Manninen Marko , Wegelius Asko 
Published: October 2022

Abstract
Background
Virtual reality technologies have been utilized in the treatment of psychiatric disorders by offering means to practice challenging situations in a safe environment. In this case report, we describe the development of a novel and easy to implement virtual reality-based intervention protocol to treat paranoid ideations of individuals with psychotic disorders.
Method
360-degree videos were filmed with a head-mounted camera, simulating everyday social situations which people with paranoid delusions often find threatening. These situations included for example walking in a crowded street or visiting a grocery store. Five weekly sessions with a clinician were included in the treatment protocol, following a treatment manual and individualized case formulation. The patients were exposed to the simulations using a virtual reality-headset.
Results
The intervention was found feasible by the clinicians and was positively received by the first pilot patients. The only observed disadvantage was nausea and dizziness caused by specific video clips. 360-degree videos as stimuli for exposure were deemed suitable.
Conclusions
Developing novel forms of treatment which are easy to pilot and to implement in day-to-day clinical environment may bridge the gap between controlled studies and standard practice. As far as we know, 360-degree videos have not been previously used in the context of psychotic disorders and their utility in the treatment paranoid ideation appears promising. Based on this pilot, creating virtual reality treatment protocols is possible without excessive resources and without any specific technical know-how. The process of development and implementation is carefully laid out so this paper can be used as a manual for similar protocols.
Trial registration:
not applicable
Individualized Portal Pressure Gradient Threshold Based on Liver Function Categories in Preventing Rebleeding After TIPS
Authors: Xia Yifu , Tie Jun , Wang Guangchuan , Zhuge Yuzheng , Wu Hao , Xue Hui , Xu Jiao , Zhang Feng , Zhao Lianhui , Huang Guangjun , Zhang Mingyan , Wei Bo , Li Peijie , Wu Wei , Chen Chao , Tang Chengwei , Zhang Chunqing 
Published: October 2022

Abstract
Background:
The evidence in Portal pressure gradient (PPG) < 12 mmHg after transjugular intrahepatic portosystemic shunt (TIPS) for preventing rebleeding mostly comes from observations in uncovered stents era. Moreover, association between Child–Pugh classes and post-TIPS hepatic encephalopathy (HE) has indicated that tolerance of PPG reduction depends on liver function. This study aimed to investigate the optimal PPG for covered TIPS and explore the optimal threshold tailored to the Child–Pugh classes to find individualized PPG to balance rebleeding and overt HE. Methods: This multicenter retrospective study analyzed rebleeding, OHE, and mortality of patients associated with post-TIPS PPGs (8, 10, 12, and 14 mmHg) in the entire cohort and among different Child–Pugh classes. Propensity score matching (PSM) and competing risk analyses were performed for sensitivity analyses. Results: We included 2100 consecutively screened patients undergoing TIPS. In all patients, PPG < 12 mmHg reduced rebleeding after TIPS (P = 0.022). In Child–Pugh class A, none of the PPG thresholds were discriminative of clinical outcomes. In Child–Pugh class B, 12 mmHg (P = 0.022) and 14 mmHg (P = 0.037) discriminated rebleeding, but 12 mmHg showed a higher net benefit. In Child–Pugh class C, PPG < 14 mmHg had a lower rebleeding incidence (P = 0.017), and exhibited more net benefit than 12 mmHg. Conclusion: Different PPG standards may be required for patients with different liver function categories. A PPG threshold < 12 mmHg might be suitable for patients in Child–Pugh class B, while < 14 mmHg might be optimal for patients in Child–Pugh class C.
Development of a Novel Technique for Measuring the 3D Sloshing in Cylindrical Tanks
Authors: Tamir U. , KATSIR O. , Gendelman O. V. , Shimshi E. 
Published: October 2022

Abstract
A novel technique for measuring the fluid sloshing in an opaque cylindrical tank is presented. The proposed measuring technique is fast and low cost but still maintains a sufficient level of accuracy while offering multiple measuring points on the circumference of the tank. The method expands the number of measuring points significantly in comparison to most methods reviewed. In order to measure all points, a single camera is mounted above the tank pointing towards its center. Markers on the internal face of the tank are used to calibrate the non-linear pixels to-height ratio of the water level as captured by the camera. The technique is able to capture different sloshing flow regimes under lateral sinusoidal excitation: planar waves, swirling waves, as well as a chaotic motion.
Evaluation the effect of Gum Arabic as prophylactic agent against chemotherapy-induced oral mucositis in cancer patients: A clinical trial
Authors: khazzan Abdulrazzaq Yahya Al , Hasan Abdel-Wahab , Eltayib Ali Elbagir , Suliman Waheeb Saleem 
Published: October 2022

Abstract
Several of oral problems such as mucositis, dry mouth and dysphagia associated with cancer therapy have significant impact on the physical status, social, and psychological behavior of cancer patients to varying degrees. The purpose of this research was to investigate the effect of Gum Arabic to prevent chemotherapy-induced oral mucositis in cancer patients. A clinical trial was conducted for a total of 374 cancer patients (14-80 years of age). Patients were categorized into two groups; 190 in the study group and 184 in the control group. The study group, who received chemotherapy were given a dose of 30 grams per day Gum Arabic orally for six weeks, while the control group received only chemotherapy. Essential data concerning the patients were recorded, and the assessment of oral mucositis was carried out weekly for six weeks. This study showed a significant (P = 0.001) reduction in the incidence of chemotherapy-induced oral mucositis in the fourth week and in the sixth week (P = 0.002). This study concluded that the regular administration of Gum Arabic has beneficial effects for cancer patients against oral mucositis induced by chemotherapy. This work registered at ClinicalTrials.gov by the following Identifier number: NCT03348241.
The p.Pro2232Leu variant in the ChEL domain of thyroglobulin gene causes intracellular transport disorder and congenital hypothyroidism.
Authors: Siffo Sofia , Pio Mauricio Gomes , Martínez Elena Bueno , Lachlan Katherine , Walker Joanna , Weill Jacques , González-Sarmiento Rogelio , Rivolta Carina Marcela , Targovnik Héctor Manuel 
Published: October 2022

Abstract
Thyroglobulin (TG), the predominant glycoprotein of the thyroid gland, functions as matrix protein in thyroid hormonegenesis. TG deficiency results in thyroid dyshormonogenesis. These variants produce a heterogeneous spectrum of congenital goitre, with an autosomal recessive mode of inheritance. The purpose of this study was to identify and functionally characterize new variants in the TG gene in order to increase the understanding of the molecular mechanisms responsible for thyroid dyshormonogenesis. A total of four patients from two non-consanguineous families with marked alteration of TG synthesis were studied. The two families were previously analysed in our laboratory, only one deleterious allele, in each one, was detected after sequencing the TG gene (c.2359C > T [p.Arg787*], c.5560G > T [p.Glu1854*]). These findings were confirmed in the present studies by Next-Generation Sequencing. The single nucleotide coding variants of the TG gene were then analyzed to predict the possible variant causing the disease. The p.Pro2232Leu (c.6695C > T), identified in both families, showing a low frequency population in gnomAD v2.1.1 database and protein homology, amino acid prediction, and 3D modeling analysis predict a potential pathogenic effect of this variant. We also transiently express p.Pro2232Leu in a full-length rat TG cDNA clone and confirmed that this point variant was sufficient to cause intracellular retention of mutant TG in HEK293T cells. Consequently, each family carried a compound heterozygous for p.Arg787*/p.Pro2232Leu or p.Glu1854*/p.Pro2232Leu variants. In conclusion, our results confirm the pathophysiological importance of altered TG folding as a consequence of missense variants located in the ChEL domain of TG.
Comparison of clinical characteristics and pathologic complete response (pCR) rate after neoadjuvant chemotherapy in very young women and older women with breast cancer
Authors: Dou He , Liu Yu qi , Yu Ping yang , Zhu Yue , Li Fu cheng , Wang You yu , Chen Xing yan , Wu Qi qi , Xiao Min 
Published: October 2022

Abstract
Purpose Age has been confirmed to be a very aggressive biological factor and associated with poor prognosis of breast cancer (BC) patients, but the effect of pathological complete response (pCR) rate after neoadjuvant chemotherapy (NAC) is still controversial, with the development of time, young women breast cancer(YWBC) gradually into people's vision, the understanding of YWBC(≤35y) is scarce. This study compares and evaluates the clinical characteristics and pCR rate after NAC in YWBC and other age women with breast cancer.
Patients and methods We retrospectively analyzed the clinicopathological data, molecular subtypes, chemotherapy regimen, and pCR rates of 1424 non-metastatic BC patients from the Affiliated Cancer Hospital of Harbin Medical University from January 1, 2012, to December 31, 2019. Categorical data were compared using the chi-square test and Fisher's exact test for multivariate data using Logistic regression models. Any predictor variable with P <0.05 in the univariate analysis was included in the multivariate regression analysis to study the relationship between different age groups and pCR.
Results A total of 879 patients in this study were eligible for analysis, and 71(8.1%) female patients were ≤35 years old.YWBC were more likely to get pCR (25.4%vs15.6%, P= 0.033). The proportion of patients with a higher clinical stages was higher. Compared with elderly patients, YWBC patients were more likely to undergo breast-conserving surgery(BCS), multivariate analyses found similar results in different age groups, and more patients with Her-2 positive and triple-negative breast cancer (TNBC). In the whole group, Age, PR expression, HER-2 expression, KI67 expression, and clinical stage were the independent predictors of pCR after NAC in BC patients (P <0.05).
Conclusion Our study found that age is the main factor affecting the achievement of pCR in patients with BC. YWBC has a higher clinical stage and a high proportion of HER-2 positive patients, which is the leading cause of poor prognosis.YWBC has a higher effect on chemotherapy therapy. We need to pay more attention to this group and achieve individualized treatment, which will help us treat BC better and provide new targets and blueprints for our clinical therapy.