bluuebunny/crossref_metadata_2025_split huggingface dataset:
Responsive Role of Nanomedicine in the Tumor Microenvironment
and Cancer Drug Resistance
Authors: Sa Pratikshya , Sahoo Sanjeeb K. , Dilnawaz Fahima 
Published: September 2022

Abstract:
Cancer remains a major worldwide health challenge. Current studies emphasize
the tumor microenvironment that plays a vital role in tumor proliferation, invasion, metastasis,
and drug resistance. The tumor microenvironment (TME) supports the cancer cell to
evade conventional treatment such as surgery, radiotherapy, and chemotherapy. Moreover,
the components of tumor microenvironments have a major contribution towards developing
therapy resistance in solid tumors. Therefore, targeting the tumor microenvironment can be
a novel approach for achieving advancement in cancer nanomedicine. The recent progress
in understanding TME and developing TME-responsive nanoparticles offers a great advantage
in treating cancer drug resistance. These nanoparticles are developed in response to
TME stimuli such as low pH, redox, and hypoxia improve nanomedicine's pharmacokinetic
and therapeutic efficacy. This review discusses the various components of the tumor microenvironment
responsible for drug resistance and nanomedicine's role in overcoming it.
Bacterial Peptides and Bacteriocins as a Promising Therapy for Solid Tumor
Authors: Yaghoubi Atieh , Ghazvini Kiarash , Hasanian Seyed Mahdi , Avan Amir , Soleimanpour Saman , Khazaei Majid 
Published: September 2022

Abstract:
The conventional treatment is faced with limitations in the treatment of solid tumors due to the specific pathophysiology of them. In recent decades, several novel therapeutics have been introduced to treat solid tumors. Among these new methods, tumor therapy using bacterial products like bacteriocins and peptides has been of great interest due to the unique characteristics and advantages of them in comparison to the conventional treatment including that they are able to precisely target tumor cells, selective toxicity for tumor cells, low side effect on normal cells, toxicity activity for MDR cancer cells, used as the target delivery vehicles and enhancing drug delivery. Moreover, their small size and low molecular weight have made them easy to synthesize and modify. Furthermore, in recent years, use of genetic engineering has expanded the therapeutic ability of peptides to treat solid tumors, which results in overcoming the peptide drawbacks. The present review mainly focuses on the new advances in the application of bacterial peptides and bacteriocins in treating human solid tumors.
Novel Synergistic Combination of Pamidronate and Temozolomide for
Breast Cancer Therapeutics
Authors: Hashim Zehra , Syed Nida , Ilyas Amber , Syed Basir , Ahmed Aftab , Zarina Shamshad 
Published: September 2022

Objective:
Human breast cancer is among one major health concerns with high prevalence
and mortality among women worldwide. Various cellular signaling pathways are implicated in carcinogenesis.
One of the major pathways that affect the downstream cellular growth cascades is Mevalonate
pathway (MVA). The inhibition of MVA is therapeutically beneficial for various cancers. Pamidronate
(PAM) (MVA inhibitor), a nitrogen-containing bisphosphosphonate, is an antiresorptive FDAapproved
drug. The objective of our study was to explore adjuvant therapy using a combination of
PAM and an alkylating agent, Temozolomide (TMZ) against breast cancer.

Methods:
We have examined the differential gene and protein expression in response to the combination
treatment strategy. For gene expression analysis RT-qPCR and for proteomic study, twodimensional
gel electrophoresis and mass spectrometry techniques were utilized.

Results:
Combination treatment (PAM+TMZ) showed more pronounced cytotoxic effect as compared
to single agent treatment. Our results indicate that MVA pathway regulatory genes (FDFT1, FDPS,
KRAS) are significantly (p<0.05) downregulated in combination-treated breast cancer cells. The differential
proteomic analysis showed lower expression of GFAP, PPA1 and TRIM68 proteins after synergistic
treatment whereas, these proteins are found to be up-regulated in multiple cancers.

Conclusion:
The present study reveals that a combination of PAM and TMZ produces an effective
anti-cancerous effect on breast cancer cells. Therefore, this novel therapeutic regimen is likely to provide
a better treatment strategy for breast cancer.
Weak Interactions between Epinephrine and Thymine
Authors: Pei Ling 
Published: September 2022

Abstract:
The weak interactions between epinephrine and thymine were investigated by combining the 6-311+G(d,p) basis set with the M06-2X method based on density functional theory. Results suggest that epinephrine and thymine form 22 steady geometries through weak interactions, which primarily contain hydrogen bonds and π–π stacking. Hydrogen bonding is the main character. In addition, the interaction energies range from −20.98 kJ•mol−1 to −63.14 kJ•mol−1 with the basis set superposition error correction, which are in line with the energy range of the hydrogen bond. Geometrical parameters, frequency analysis, natural bond orbital (NBO) analysis, atoms-in-molecules (AIM) analysis, and reduced density gradient (RDG) analysis were also used to analyze and verify hydrogen bond formation. Most of the hydrogen bonds in optimized structures of the epinephrine–thymine complex are closed-shell interaction and electrostatic dominant, whereas N•••H–N, which exist in geometries 3, 4, 5, and 14, are interacting between the closed-shell and shared-shell. N-H…N is almost linear, which is more conducive to the study of the role of hydrogen bonds in the system.
An Immediate Allergic Reaction Following the Anti-COVID-19 Vaccine
Pfizer-BioNTech: A Case Report
Authors: Miqdadi Amal , Abousahfa Imad , Nafaa Mourad , Noussair Mostapha , Jidane Said , Belyamani Lahcen 
Published: September 2022

Objective:
To date, the vaccine is the only weapon to stop the global pandemic caused by the SARS-CoV-2. But, several clinical cases of complications have been reported in the literature especially allergic reactions.

Case Report:
We report a case of 35-year-old woman, known asthmatic with history of chronic urticaria, allergic rhinoconjunctivitis and angioedema after taking NSAIDs. The patient was presented 10 minutes after administrating Pfizer-BioNTech vaccine, an immediate allergic reaction complicated 12 hours followed by angioedema

Discussion:
During the first wave of COVID-19, and after the initiation of the vaccination program in Morocco, vaccinating people with severe allergies was not recommended. This reality was changed after the second wave of SARS-CoV-2 Delta, on condition of doing it under medical monitoring. We should propose to all risky persons to take premedication if needed to avoid such reactions considering the benefits incurred. The use of anti-histamines seems to be necessary. But as in our patient’s case, anti-histamines alone were not sufficient to avoid this local reaction. They probably reduced the intensity of the reaction but did not avoid it. Therefore, we proposed a combination of drugs made by corticosteroids and anti-histamines as a premedication may be a safe alternative for the patients with risks and last but not least a, close monitoring was proposed.

Conclusion:
The main purpose of this case is to raise awareness of this side effect among practitioners and make them capable to manage it correctly.
Successful Combination of Remdesivir and Convalescent Plasma to Treat
a Patient with Rituximab-Related B-Cell Deficiency and Prolonged
COVID-19: A Case Report
Authors: Raho Giorgio , Cordeddu William , Firinu Davide , Del Giacco Stefano , Angioni Goffredo 
Published: September 2022

Background:
Treatment of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection in immuno-compromised patients with complete B cell depletion
can be really challenging due to the lack of seroconversion and long-lasting disease.

Case Report:
We describe a case of long-lasting coronavirus disease (COVID-19) in a female patient with rheumatoid arthritis who was treated with rituximab and continued to show B-cell depletion. An ongoing replication of SARS-CoV-2 was demonstrated for a period of 8 months when nasopharyngeal swabs were tested. She was treated once with remdesivir but without lasting resolution, and she was then treated with convalescent plasma but with a similar effect. Only with a combination of both treatments was clinical resolution achieved. The patient's lack of seroconversion and the prolonged course of the disease illustrate the importance of humoral immunity in resolving SARS-CoV-2 infection. This case report highlights challenges in managing immunocompromised hosts, who may act as persistent shedders and sources of transmission.

Conclusions:
The combination of remdesivir and convalescent plasma resulted in successfully
achieving clinical resolution of SARS-CoV-2 infection in our patient.
Los efectos del aprendizaje en línea autorregulado en la ineficacia del aprendizaje en el contexto de la COVID 19
Authors: He Wei , Zhao Li , Su Yu-Sheng 
Published: September 2022

Durante la pandemia de la/el COVID y la nueva normalidad, el aprendizaje en línea se ha convertido en una de las principales opciones para aprender. Estudios previos sobre el aprendizaje autorregulado demuestran que es un mejor indicador de la eficacia del aprendizaje en línea; no obstante, esta discusión no se ha extendido a la pandemia de la COVID-19. Para acortar la brecha, este estudio pretende explorar la relación entre las tres fases del aprendizaje autorregulado (AAR) y la eficacia del aprendizaje. Se recolectaron datos de 370 estudiantes de bachillerato durante el periodo de la pandemia por COVID-19. Se usaron modelos de ecuaciones estructurales en los datos para llevar a cabo el análisis factorial confirmatorio. Los resultados demuestran que la fase de planificación estaba relacionada positivamente con las fases de ejecución y autorreflexión; y que la fase de ejecución estaba relacionada positivamente con la fase de autorreflexión; por otra parte, las fases de ejecución y autorreflexión estaban relacionadas negativamente con la ineficacia del aprendizaje. Además, la fase de planificación no tuvo una relación directa con la ineficacia del aprendizaje, pero la fase de planificación estaba correlacionada con la ineficacia del aprendizaje, intermediada por las fases de ejecución y autorreflexión. Estos resultados sugieren que un mejor desempeño en las tres fases del aprendizaje autorregulado disminuye la ineficacia del aprendizaje en línea percibida por los estudiantes. Este conocimiento puede tener implicaciones en la educación global.
Predictors of the Initiation of Islet Autoimmunity, Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study
Authors: Krischer Jeffrey P. , Liu Xiang , Lernmark Åke , Hagopian William A. , Rewers Marian J. , She Jin-Xiong , Toppari Jorma , Ziegler Anette-G. , Akolkar Beena , Group the TEDDY Study 
Published: September 2022

<p> </p>
<p><em>Objective:</em> To distinguish among predictors of seroconversion, progression to multiple autoantibodies and from multiple autoantibodies to type 1 diabetes in young children. </p>
<p><em>Research Design and Methods:</em> Genetically high-risk newborns (n=8502) were followed for a median of 11.2 y (IQR 9.3-12.6 y); 835 (9.8%) developed islet autoantibodies and 283 (3.3%) were diagnosed with type 1 diabetes. Predictors were examined using Cox proportional hazard models.</p>
<p><em>Results:</em> Predictors of seroconversion and progression differed, depending on the type of first appearing autoantibody. Male sex, Finnish residence, having a sibling with type 1 diabetes, the HLA DR4 allele, probiotic use before age 28 days, and SNP rs689_A (INS) predicted seroconversion to IAA-first. Increased weight at 12 months and SNPs rs12708716_G (CLEC16A) and rs2292239_T (ERBB3) predicted GADA-first. Having a father with type 1 diabetes, the SNPs rs2476601_A (PTPN22) and rs3184504_T (SH2B3) predicted both. Younger age at seroconversion predicted progression from single to multiple autoantibodies as well as progression to diabetes, except for those presenting with GADA-first. Family history of type 1 diabetes and the HLA DR4 allele predicted progression to multiple autoantibodies, but not diabetes. Sex did not predict progression to multiple autoantibodies, but males progressed more slowly than females from multiple autoantibodies to diabetes. SKAP2 and MIR3681HG SNPs are newly reported to be significantly associated with progression from multiple autoantibodies to type 1 diabetes. </p>
<p><em>Conclusions: </em>Predictors of IAA-first vs GADA-first autoimmunity differ from each other and from the predictors of progression to diabetes.</p>
Who Should You Listen to in a Crisis? Differences in Communication of Central Bank Policymakers
Authors: Lehtimäki Jonne , Palmu Marianne 
Published: September 2022

Abstract
Communication has become a vital part of modern monetary policy, and its importance is even higher during a crisis when a central bank has to calm the markets down. This paper studies the information content of different styles of communication from individual central bank policymakers in the European Central Bank and the Federal Reserve during a period of very high economic uncertainty, and whether it differs depending on the role or position of the speaker. The findings suggest that during the financial crisis there was a large variance in the information content of different policymakers and styles of communication.
Core Job Characteristics and Personal Work Outcomes: The Mediating Role of Critical Psychological States: Empirical Evidence from Northern Cyprus Hotel Sector
Authors: Sleimi Mohammad , Elayan Malek Bakheet , Hajleh Lamar Abu 
Published: September 2022

Abstract

Background and purpose: The purpose of this study is to investigate the relationship between core job characteristics (CJC) and personal work outcomes (OUT), as well as the roles of experienced meaningfulness of work (EMW) and experienced responsibility for outcomes of work (EROW) in mediating the CJC–OUT relationship. Specifically, this study attempts to examine the effectiveness of CJC in improving EMW and EROW and to shed light on the roles of EMW and EROW in enhancing the OUT of employees in the Northern Cyprus hotel sector.

Methods: This study adopted a quantitative approach to collect and analyze the data from 420 tourism stakeholders in Northern Cyprus hotel sector. A partial least squares (PLS) technique using Smart-PLS was applied to test the direct relationships within the research model and determine any mediating effects.

Results: The analysis revealed strong support for meaningfulness of work and experienced responsibility for outcomes of work acting as partial mediators in the relationship between core job characteristics and personal work outcomes. Moreover, core job characteristics was found to have a reasonable direct effect on personal work outcomes, experienced meaningfulness of work, and experienced responsibility for outcomes of work.

Conclusion: The current study points to the importance of including experienced meaningfulness of work and experienced responsibility for outcomes of work as mediating variables to understand better the relationship between core job characteristics and Personal work outcomes. Several theoretical and practical implications are included before pinpointing the directions of potential future studies that makeup on the evidence-based argument regarding the results of this study. Lastly, top management in hotel sector would benefit from job redesign because the results demonstrated that the core job characteristics have a positive effect on their work outcomes.
Efficiency of hybrid surgical treatment of the aortic arch and descending thoracic aorta aneurysm
Authors: Shlomin V. V. , Bondarenko P. B. , Shloydo E. A. , Puzdriak P. D. , Didenko Yu. P. , Uzhakhov I. R. , Petrova K. A. , Gusinskiy A. V. , Erofeev A. A. , Akimova K. R. 
Published: September 2022

OBJECTIVE. Assessment of the mid-term results after various types of debranching in hybrid surgery of the aortic arch and descending thoracic aorta.METHODS AND MATERIALS. 47 patients with various pathologies of the aortic arch and descending thoracic aorta were operated on. Six of them suffered from type IIIa dissection and 26 from type IIIb dissection according to DeBakey classification, 15 patients had true aortic aneurysms. The following interventions were performed: total aortic arch debranching (n=5), cross subclavian-subclavian-left-common carotid (n=14) or cross carotid-carotid-subclavian bypass (n=7); subclavian-carotid transposition or bypass (n=12); Chimney technique for the aortic arch aneurysm (n=8); in situ fenestration of the endoprosthesis (n=1). Elective surgery was performed in 32 patients, emergency in 15.RESULTS. Technical success achieved in 100 %. The overall hospital mortality rate was 10.6 % (n=5), elective surgery mortality rate was 9.3 % (n=3), in emergency cases - 13.3 % (n=2). Causes of mortality: stroke (n=1), multiple organ failure after prosthetic ascending aorta due to retrograde dissection after stent graft implantation (n=1), pneumonia (n=1), acute myocardial infarction (n=1), profuse bleeding (n=1). Cumulative survival rate was 87.5 % over 5 years, freedom from reinterventions - 89.1 %. During the first year of observation, 3 patients underwent stent graft replacement of the descending thoracic aorta due to formation of a dissection below the primary stent graft (n=1), open prosthesis of the ascending aorta due to it retrograde dissection (n=1), endofixation of the stent graft with embolization of the false lumen (n=1).CONCLUSION. Hybrid surgery on the aortic arch and the descending thoracic aorta is safe and effective treatment. Regular follow-up and timely treatment of complications in the long term after hybrid or endovascular interventions are necessary to improve long-term results.
Risk factors for infectious complications after total elbow arthroplasty
Authors: Boyarov A. A. , Ambrosenkov A. V. , Aliev A. G. , Tikhilov R. M. , Shubnyakov I. I. 
Published: September 2022

INTRODUCTION. Total elbow arthroplasty (TEA) is a good alternative surgical solution for many patients with severe traumatic and inflammatory joint injuries. However, this surgical procedure is characterized by a rather high incidence of periprosthetic joint infection (PJI): from 3 to 8 %. At present, the issue of the influence of various factors on the risk of PJI is relevant.The OBJECTIVE of the study was to identify risk factors for the development of PJI after primary TEA.METHODS AND MATERIALS. In a retrospective study, the data of 485 patients who underwent primary and revision TEA from 2003 to 2019 were analyzed. The total number of studied patients was divided into 2 groups. The main group consisted of 51 patients who underwent revision TEA for PJI. The control group included 434 patients who underwent primary TEA.RESULTS. Evaluation of the effect of the primary diagnosis on the risk of PJI development showed a statistically significant relationship only in patients with gunshot wounds of the elbow joint (p=0.01). In the study of possible anamnestic factors, the following were significant: a history of previous interventions on elbow joint (p=0.004), previous infection (p <0.001) and open fracture of the elbow (p=0.009).CONCLUSION. In the course of the study, we proved the influence of anamnestic factors in the occurrence of PJI. Performing a two-stage revision allows stopping the infectious process with high efficiency in most cases.
Downward penetrating endplate screw technique under O-arm navigation posterior fusion in patients with osteoporotic vertebral body fractures associated with diffuse idiopathic skeletal hyperostosis
Authors: Shiraishi Daimon , Yamamoto Yu , Motonori Ishii , Nishimura Yusuke , Hara Masahito , Saito Ryuta , Takayasu Masakazu 
Published: September 2022

Background:
A downward penetrating endplate screw (PES) technique combined with caudal anchor screws inserted in the upward direction under O-arm navigation (i.e., crossing screw technique) avoided screw backout and proximal junctional kyphosis (PJK) in three patients with osteoporotic vertebral body fractures and diffuse idiopathic skeletal hyperostosis (DISH).

Methods:
The PES techniques were utilized for patients with T12 (one patient) and L1 (two patients) spontaneous fusion across the targeted vertebrae, with minimal damage to the involved endplates/intervertebral discs. The average number of instrumented vertebrae was 5.3.

Results:
There were no perioperative complications over the mean follow-up period of 28.7 months; no screw loosening, and no PJK.

Conclusion:
The PES technique prevented screw backout, and PJK in three patients with lumbar osteoporotic vertebral fractures and DISH.
Incidence of radiculopathy following lumboperitoneal shunt placement without fluoroscopy for normal pressure hydrocephalus
Authors: Tanaka Tatsuya , Goto Hirofumi , Momozaki Nobuaki , Honda Eiichiro 
Published: September 2022

Background:
Spinal catheter insertion in lumboperitoneal shunt (LPS) surgery for normal pressure hydrocephalus (NPH) can result in radiculopathy due to mechanical irritation of the nerve roots of the cauda equina. Here, we analyzed the position of LPS shunts placed without portable fluoroscopy in 72 patients, a subset of whom developed postoperative radiculopathy.

Methods:
We retrospectively analyzed how frequently 72 consecutive NPH patients experienced radiculopathy following LPS catheter placement performed without intraoperative fluoroscopy.

Results:
The rate of incorrect catheter placement was 15.3% (11/72 cases). We observed that is, downward placement in 6.9% (5/72 cases), hyperflexion in 6.9% (5/72 cases), and subcutaneous migration in 1.4% (1/72 cases) patients. One patient with initial correct LPS placement developed radicular pain 5-day postoperatively attributed to 1-cm of catheter movement; they recovered simply by utilizing oral analgesics for 1-month duration.

Conclusion:
LPS insertion without fluoroscopic guidance resulted in a 15.3% risk of spinal catheter displacement. We suggest, therefore, that intraoperative imaging guidance be utilized for the placement of LPS in patients with NPH and/or for other pathology to avoid the 15.3% risk of postoperative radiculopathy.