bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of heat shock proteins in the pathogenesis of some components of metabolic syndrome
Authors: Хохлова А.В. , Бойченко П.К. , Востриков А.А. , Магомедов М.У. 
Published: October 2022

Проблема изучения метаболического синдрома (МС) на протяжении долгого времени остается крайне важной. Масштабы и темпы распространения входящих в синдром патологических состояний таких как: ожирение, артериальная гипертензия (АГ), сахарный диабет 2 типа (СД 2), дислипидемия, гиперинсулинемия и пр., придали МС статус пандемии XXI века. В последнее время большинство исследований направлено на поиск маркеров риска развития МС с целью предиктивной и превентивной диагностики. Обзор посвящен анализу возможного участия белков теплового шока (БТШ) в различных патологических процессах, сопровождающих МС. Знание молекулярных механизмов патогенеза МС играет важную роль в разработке персонализированного подхода к ведению таких пациентов, а дальнейшее углубленное исследование БТШ может позволить использовать данные белки в качестве одной из возможных мишеней при разработке методов лечения МС.
Studying metabolic syndrome (MS) has remained extremely important for a long time. The magnitude and increasing prevalence of pathological conditions that comprise this syndrome, such as obesity, arterial hypertension (AH), type 2 diabetes mellitus (T2DM), dyslipidemia, hyperinsulinemia, etc., have given MS a status of pandemic of the 21th century. Recently, for prevention and prognosis, most studies have focused on identifying risk factors for MS. This review analyzes the participation of heat shock proteins (HSPs) in various pathological processes emerging in MS. The knowledge of molecular mechanisms of MS pathogenesis plays an important role in developing a personalized approach for managing MS patients. Detailed studies of HSPs may allow using these proteins as possible targets in the development of MS treatments.
Cement and Clay Bricks Reinforced with Coconut Fiber and Fiber Dust
Authors: Rajapakse Anjan Mevan , Mudunkotuwa Dulini Yasara , Sanura Naveen Sanjula  , Kelum Nishantha  , Bandara Tharaka Ruwan 
Published: October 2022

For generations, Sri Lankans use cement bricks and clay bricks as common building materials in the construction field. This study investigates the feasibility of improving the strength while lowering the mass and thermal conductivity of bricks by adding coconut fiber or coconut fiber dust as a reinforcing material. Each reinforcing material is used in both clay and cement bricks. The mixtures are prepared according to varying volume ratios of the raw materials used. Coconut fibers are combed and cut into 4-5 cm pieces and dry coconut fiber dust is sieved using a 4 mm sieving mesh. The mixture is prepared by hand mixing and the traditional processes are replicated in making the bricks. Tests are carried out to understand the variation of mass, compressive strength, thermal conductivity, and water absorption of the reinforced bricks in comparison to bricks with no reinforced material. The cement brick reinforced with coconut fiber achieves the expected results in the compressive strength test and thermal conductivity test but underperformed when comparing masses and water absorption. Clay bricks reinforced with coconut fiber dust show impressive results in compressive tests and with the addition of dust, the appearance seems to have changed. It is observed that reinforcing cement bricks with coconut fiber could double the compressive strength along with a 5% reduction in mass. Reinforcing clay bricks with coconut fiber dust increases its compressive strength by over 70% while decreasing the mass by over 30 %. The study proves that it is feasible to use reinforced coconut fiber or coconut fiber dust to improve the properties of both clay and cement bricks, while clay bricks reinforced with coconut fiber are an exception.
Man-In-The-Middle Attack
Authors: DİCLE Salih Zafer 
Published: October 2022

Everyone has accepted that the most vital resource of our age is information. As information is felt more and more as a power factor, great changes are taking place in our ways of thinking and perceiving, our research methods and our lifestyles. In this context, the importance of cyber threats has emerged especially in recent years and the ways to protect these threats are a matter of discussion. MITM attacks pose a significant threat to network security as they interrupt communication between two systems and allow an attacker to instantly capture and manipulate critical information. In this process, the victim continues to connect to the internet as if nothing has happened, but all the sites you are connected to with the computer are now visible. This attack is a form of eavesdropping in which the attacker controls all speech.
In this study, as the system, or in other words, the network administrator, it is ensured that the network security is fully ensured by using smart manageable switch devices in the computer network of the said attacks and making the necessary arrangements.
Evaluation of the health performances of the regions affiliated to the the ministry of health by multi-criteria decision making techniques
Authors: SARIYILDIZ Abdurrahman Yunus 
Published: October 2022

Aim: The aim of this study is to determine the health performances of the regions in the 2019 Health Statistics Yearbook by using multi-criteria decision making techniques.
Material and Method: The study is a cross-sectional study and the data used in the study were obtained from the Ministry of Health Statistics Yearbook 2019. The population of the study consists of 12 regions (Western Anatolia, Western Black Sea, Eastern Black Sea, Eastern Black Sea, Eastern Marmara, Aegean, Istanbul, Central Anatolia, Mediterranean, Northeastern Anatolia, Western Marmara, Southeastern Anatolia, and Central Anatolia) included in the 2019 Health Statistics Yearbook. No sample was selected, and all regions were included in the study. ENTROPY Method was used for weighting the criteria and TOPSIS Method was used for ranking the alternatives. A total of 11 criteria, including six benefit criteria (number of general practitioners per 100,000 people, number of specialists per 100,000 people, number of hospital beds per 10,000 people, number of nurses and midwives per 100,000 people, number of hemodialysis devices per million people, and number of MRI devices per million people) and 5 cost criteria (infant mortality rate, maternal mortality rate, population per family medicine unit, crude mortality rate, population per 112 emergency aid station) were evaluated. Analyses were performed in Microsoft Excel program.
Results: In the study, the three most effective criteria used to determine the health performances of the regions were respectively determined as maternal mortality rate (28.68%), population per 112 emergency aid stations (17.43%), and crude death rate (15.63%). As a result of the analyzes of the TOPSIS Method, the five regions with the best health performance among the regions are Western Anatolia (0.68), Western Black Sea (0.66), Eastern Black Sea (0.65), Eastern Marmara (0.63), and Aegean (0.56) has been identified. While the average performance score of the regions is found as 0.53, Istanbul (0.51), Middle East Anatolia (0.50), Mediterranean (0.49), Northeast Anatolia (0.46), West Marmara (0.44), Southeastern Anatolia (0.40), and Central Anatolia (0.33) regions remained below this average.
Conclusion: The most important criteria in evaluating the health performances of regions are; maternal mortality rate, population per 112 emergency aid stations, and crude death rate. The regions with the best health performance are Western Anatolia, Western Black Sea and Eastern Black Sea. In order to improve the health performance of the regions, maternal mortality rate, crude death rate and population per family physician should be reduced.
Evaluation of violence against emergency physicians
Authors: KILIÇ Mazlum , KOÇAK Mehmet 
Published: October 2022

Aim: To identify the causes of violence in the emergency department and suggest ways to reduce the violence experienced.
Material and Method: The population of this cross-sectional survey study consisted of all emergency medicine physicians who participated in the symposium on frequent emergencies held in Cyprus on May 6, 2022. The survey consisted of a total of 20 items comprising 16 multiple-choice and four fill-in-the-blank questions related to demographic characteristics and violence. It was administered to 230 physicians who volunteered to participate in the study.
Results: A total of 230 physicians, 65.2% (n=150) male and 34.8% (n=80) female, participated in the study. It was determined that 28.7% of the participants had been exposed to physical violence, 89.2% to verbal violence, and 1.3% to sexual violence within the last year. The factors causing violence were identified as the low educational level of patients’ and their family members, patient requests for unnecessary medical practices, aggressive nature of family members, and patients’ desire to be examined before their turn. As the number of shifts worked by the physicians and number of treated patients increased, the frequency of exposure to violence also increased. Women were exposed to more violence. As the title and age of the physicians increased, the frequency of exposure to violence decreased.
Conclusion: We consider that violence against physicians can be reduced by informing patients and patient’s relatives and improving the working conditions of physicians.
Platelet-to-lymphocyte ratio and mean platelet volume-to-platelet count ratio for predicting mortality in critical COVID-19 patients
Authors: CANKAR DAL Hayriye , YALNIZ Kudret Yasemin , TOSUN Damla , GÖZÜKARA Bilge , ŞİRİN Hülya , DOĞU Cihangir , ÖZTÜRK KAZANCI Dilek , TURAN Sema 
Published: October 2022

Introduction: Defining the markers that can be used in clinical practice for predicting the mortality of critical patients will be cautionary for taking necessary measures in high-risk cases. Although there are a large number of studies conducted during the pandemic, no mortality marker to predict the prognosis of intensive care unit (ICU) patients with COVID-19 has yet been defined. Platelet indices can be easily evaluated with a complete blood count (CBC) analysis, one of the most accessible tests worldwide. This study aimed to evaluate the role of platelet indices such as mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), platelet-to-lymphocyte ratio (PLR), and MPV-to-platelet count ratio (MPV/PLT) in predicting the mortality of ICU patients with COVID-19.
Material and Method: This single-center, retrospective, cross-sectional study included 201 critical COVID-19 patients over 18 years of age who were hospitalized in ICU between August 2020 and February 2021. Patients were divided into two groups as survivors and non-survivors. The relationship of MPV, PDW, PCT, PLR, and MPV/PLT parameters evaluated at ICU admission with mortality was investigated.
Results: There was no significant difference between the survivor and non-survivor groups in terms of platelet count, MPV, PCT, and PDW. The comparison of the platelet ratios revealed higher PLR and MPV/PLT ratio in the non-survivor group than in the survivor group (p
What is the role of YouTube™ as a source of information on trichotillomania?
Authors: AKKUŞ Merve , AYDOĞAN AVŞAR Pınar 
Published: October 2022

Objective: YouTube™ is a very popular video site worldwide and is increasingly being used to access health information. The content in these videos is often incomprehensible and worse, contains inaccurate and incomplete information. This article aims to evaluate the reliability and usefulness of information about TTM available to patients on YouTube™.
Material and Method: This study has a cross-sectional design. 51 videos were reviewed. Global quality score (GQS), modified DISCERN and trichotillomania Youtube score (TTMYS) were used for the quality analysis of the videos. Video duration(sec), time since upload (months), Number of views/comments/likes/dislikes were analyzed.
Results: The majority of the videos (31.4%) were uploaded by physicians, and the least by hospitals (3.9%). The mean GQS score was 2.06±1.363, the modified DISCERN score was
2.06±1.348, and the TTMYS score was 8.45±3.126. The GQS scores 1-2 (low quality), 3 (moderate quality), and 4-5 (high quality) were 68.6%, 11.8%, and 19.6%, respectively. The vast majority of videos were rated as low quality.
Conclusion: The TTM related video content rewieved was largely inadequate. Information about the disease and treatment options were insufficient. It is necessary to either take a primary role in uploading high-quality videos or establish supervisory mechanisms for the security and accuracy of information.
The relationship between vitamin D deficiency and hypertensive organ damage
Authors: ŞABANOĞLU Cengiz , İNANÇ İbrahim Halil 
Published: October 2022

Aim: In this study, we aimed to examine the relationship between vitamin D level and target organ damage (TOD) in primary hypertension patients by eliminating the effects of hypertension duration and antihypertensive treatments.
Material and Method: The study included 144 patients with primary hypertension. Vitamin D levels were classified as sufficiency (VDS), deficiency (VDD), and severe deficiency (VDSD). In case of more than one TOD indicator (microalbuminuria or proteinuria, left ventricular mass index and carotid intima-media thickness), it was considered as multi organ involvement (OI). In the multiple regression model, besides the traditional risk factors, the effects of hypertension duration and anti-hypertensive treatments were adjusted.
Results: The rates of VDS and VDD were lower in TOD (+) compared to TOD (-) (14.1% vs 51.5%, 32.1% vs 42.4%; p
Evaluation of proprioceptive balance results of amateur athletes following anterior cruciate ligament reconstruction: Hamstring autograft
Authors: GÜZEL Nizamettin , GENÇ Ahmet Serhat , KEHRİBAR Lokman , YILMAZ Ali Kerim 
Published: October 2022

Aim: Anterior cruciate ligament (ACL) is one of the main ligaments which provide mechanical stability of the knee, control the anteroposterior translation and rotation movements and play a key role in neuromuscular stability. The aim of the present study is to compare the 6th month balance results on operated and non-operated sides of athletes who underwent ST/G anterior cruciate ligament reconstruction (ACL).
Material and Method: The study was evaluated as a retrospective cohort consisting of patients who underwent semitendinosus/gracilis hamstring autograft (ST/G) ACL reconstruction (n=24) technique between May 2020 and October 2021. CSMI-TecnoBody PK-252 was used to determine the 6th month post-operative static balance measurements of patients. The tests were applied to both ACLR side and contralateral healthy side.
Results: Compared to pre-operative levels, there was a significant improvement in the mean Lysholm, Tegner, and IKDC scores at the post-operative level (p0.05).
Conclusion: It is seen that 6 month post-operative findings of ST/G ACLR technique show similar results with the healthy contralateral side. This result is valuable in terms of balance scores showing similar results for both sides.
Comparison of culture-positive and culture-negative severe infectious keratitis leading to hospitalization: a tertiary referral center experience
Authors: TUTAŞ GÜNAYDIN Nesrin , KANDEMİR Baran , DOGAN GOKCE Gizem , ÖZEN Mehmet Can , DÖNMEZ GÜN Raziye , HACISEYİTOĞLU Demet 
Published: October 2022

Aim: To compare the predisposing factors, surgical interventions, length of hospital stay (LOHS), and treatment outcomes of culture-positive (CP) versus culture-negative (CN) severe infectious keratitis (IK) resulting in hospitalization in a tertiary referral clinic.
Material and Method: We retrospectively reviewed the medical and microbiological records of 287 patients clinically diagnosed with severe keratitis over a 4-year period.
Results: Of 287 study participants, 141 (49.1%) had positive CP results. The most common ocular risk factor was a previous ocular surgery (45.6%), and keratoplasty was the first among these ocular surgeries (90.8%). Staphylococcus epidermidis (22.7%) was the most commonly isolated microorganism followed by fungi (17.7%). The initial and final visual acuities did not differ significantly between the CP and CN groups. Major and minor surgical interventions did not significantly differ between the groups (p=0.05). The rates of clear corneal graft in the CP group (p =0.002) were significantly higher than the rates of graft failure in the CN group (p=0.033). No significant difference was noted in the mean LOHS between groups (p=0.66). Logistic regression analyses showed that surgery during admission, S. epidermidis infection, and connective tissue diseases were independent risk factors for a prolonged hospital stay.
Conclusion: The initial and final visual acuities, surgical interventions, and LOHS were similar between the CP and CN groups. However, graft failure rates were significantly higher in patients with CN keratitis than in those with CP keratitis.
Flow distribution optimization of parallel pumps based on improved mayfly algorithm
Authors: Hou Shuai , Yu Junqi , Su Yucong , Liu Zongyi , Dai Junwei 
Published: October 2022

An improved mayfly algorithm is proposed for the energy saving optimization of parallel chilled water pumps in central air conditioning system, with the minimum energy consumption of parallel pump units as the optimization objective and the speed ratio of each pump as the optimization variable for the solution. For the problem of uneven random initialization of mayflies, the variable definition method of Circle chaotic mapping is used to make the initial position of the population uniformly distributed in the solution space, and the mayfly fitness value and the optimal fitness value are incorporated into the calculation of the weight coefficient, which better balances the global exploration and local exploitation of the algorithm. For the problem that the algorithm is easy to fall into the local optimum at the later stage, a multi-subpopulation cooperative strategy is proposed to improve the global search ability of the algorithm. Finally, the performance of the improved mayfly algorithm is tested with two parallel pumping system cases, and the stability and time complexity of the algorithm are verified. The experiments show that the algorithm can get a better operation strategy in solving the parallel water pump energy saving optimization problem, and can achieve energy saving effect of 0.72% 8.68% compared with other optimization algorithms, and the convergence speed and stability of the algorithm have been significantly improved, which can be better applied to practical needs.
Lassa Fever cases suffer from severe under-reporting based on reported fatalities
Authors: Simons David 
Published: October 2022

INTRODUCTION: Lassa Fever is a viral haemorrhagic fever endemic to eight West African countries. Symptomatic disease is expected to occur in 20% of those infected, transmission typically occurs from viral spillover from rodent hosts. The combination of limited access to diagnostics and access to healthcare means the true burden of this disease is unknown.

METHODS: The case fatality rate among confirmed, probable, and possible cases of Lassa Fever in endemic regions is expected to be around 15%. Here, annual reported cases and deaths have been used to estimate the case fatality rate, using three subsets of available data, to understand the scale of under-reporting of severe human cases.

RESULTS: 38 records of Lassa Fever reported cases and deaths were produced comprising 5,230 reported cases and 1,482 reported deaths from 7 countries. The estimated case fatality rate ranges from 16.5-25.6% (S.D. = 11.5-32.2%). The expected number of severe cases between 2012-2022 is 8,995 with currently reported numbers 58% of the expected.

CONCLUSION: This analysis highlights current uncertainty and systemic under-reporting of the morbidity and mortality burden of Lassa Fever in its endemic region and must be considered when discussing the epidemiology of this neglected tropical disease.
Nodulo-ulcerative syphilis – case report and the review of literature
Authors: Skiepko U , Serwin AB , Piłasewicz-Puza A , Flisiak I 
Published: October 2022

<p><strong>ABSTRACT</strong><br />We describe the case of tertiary syphilis involving the skin. The lesions had a nodular-ulcerative form, localized on both arms. The patient had high titers of treponemal and non-treponemal serological tests for syphilis and histopathological picture was indicative for nodulo-ulcerative syphilis. No cardiological, neurological or ophtalmological abnormalities were found. The patient was treated with 2.4 million units i.m. of benzathine benzylpenicillin three times at weekly intervals, according to European Guideline. Unfortunately, the patient was lost for scheduled follow-up. More than two years later the skin lesions healed completely leaving discrete scars and a four-fold decline in a titre of Venereal Disease Laboratory Test was noticed.</p>
<p><strong>STRESZCZENIE</strong><br />Prezentujemy przypadek pacjenta z kiłą trzeciego okresu z zajęciem skóry pod postacią kiły guzkowo-wrzodziejącej w obrębie kończyn górnych. Chory miał wysokie miana odczynów krętkowych i niekrętkowych i obraz mikroskopowy typowy dla tej postaci kiły. Pacjent otrzymał trzy dawki benzylpenicyliny benzatynowej, każda po 2,4 mln j. w odstępach tygodniowych, zgodnie z Zaleceniami Europejskimi. Niestety, nie zgłosił się do żadnej z wyznaczonych wizyt kontrolnych. Po ponad dwóch latach stwierdzono całkowite wygojenie zmian skórnych z pozostawieniem dyskretnych blizn oraz 4-krotny spadek miana odczynu VDRL.</p>
Florida Citrus Rootstock Selection Guide, 3rd Edition
Authors: Castle William S. , Bowman Kim D. , Grosser Jude W. , Futch Stephen H. , Graham James H. 
Published: October 2022

Information about citrus rootstocks has become an important part of understanding and managing citrus greening (Huanglongbing or HLB). This selection guide covers 20 characteristics of 45 citrus rootstocks and explains its methodology in detail. This revised 3-page fact sheet was written by William S. Castle, Kim D. Bowman, Jude W. Grosser, Stephen H. Futch, and James H. Graham and published by the UF Department of Horticultural Sciences, May 2015.
SP248/HS1260: Florida Citrus Rootstock Selection Guide, 4th Edition (ufl.edu)
Vespiform Thrips Franklinothrips vespiformis Crawford (Insecta:Thysanoptera: Aeolothripidae)
Authors: Mao Runqian , Xiao Yingfang , Arthurs Steven P. 
Published: October 2022

Franklinothrips vespiformis Crawford is a predatory thrips with a pantropical distribution. The distinctive red, humped-back larvae and fast-moving ant-like adults are predaceous on small arthropods. In addition to being easily mistaken for an ant, this beneficial thrips is unusual in that it constructs a silken cocoon within which it pupates. Males of this species are rare. This species is sold for use as a biological control agent in botanical gardens, zoos, interior landscapes, research greenhouses, nurseries with ornamental plants as well as outdoors in subtropical regions. This 4-page fact sheet was written by Runqian Mao, Yingfang Xiao, and Steven P. Arthurs, and published by the UF Department of Entomology and Nematology, March 2015. (Photo credit: Runqian Mao, UF/IFAS)
EENY621/IN1083: Vespiform Thrips Franklinothrips vespiformis Crawford (Insecta: Thysanoptera: Aeolothripidae) (ufl.edu)