bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fitter Fontans for future—Impact of physical exercise on cardiopulmonary function in Fontan patients
Authors: Weigelt Annika , Fritsch Regina , Rottermann Kathrin , Wällisch Wolfgang , Moosmann Julia , Dittrich Sven , Purbojo Ariawan , Schöffl Isabelle 
Published: September 2022

BackgroundIn Fontans, exercise tolerance is poorer compared to their healthy peers. Higher V˙O2peak represents a strong predictor for mortality and morbidity in these patients. Cardiac rehabilitation programs have been shown to improve cardiopulmonary function in Fontans. More habitual physical activity should therefore lead to a better exercise tolerance.MethodsWe performed cardiopulmonary exercise testing in 24 Fontan patients who had engaged in physical activity for a minimum of 3 h per week over their lifetime. As a control we performed cardiopulmonary exercise testing in 20 Fontan patients who had undertaken no physical activity or &lt;3 h per week in the past.ResultsA total of 44 Fontan patients was included (mean age 18.1 years). The mean parameters measured at peak exercise differed significantly between the active and inactive group (peak oxygen uptake [V˙O2peak] of 34.0 vs. 25.0 ml/min/kg, peak heart rate (HR) of 169.8/min vs. 139.8/min). Even though the O2pulse and the EF did not differ significantly between both groups, N-Terminal-Pro-B-Type Natriuretic Peptide (NT-pro BNP) was significantly higher in the inactive group. The two groups did not differ with respect to their cardiac function determined by magnetic resonance imaging (MRI). V˙O2peak was positively correlated with hours of sports performed by Fontans.ConclusionsV˙O2peak and maximum HR were significantly higher in Fontans who had been physically active compared to those who had been inactive. The values reported in this study were higher than in other studies and reached normal values for V˙O2peak for most Fontans in the physically active group. The positive correlation between V˙O2peak and physical activity is an indicator of the importance of incorporating physical exercise programs into the treatment of Fontan patients.
Mechanical mechanism of in situ stress ratio limit and its evolution simulation
Authors: Chen Yifei , Wang Yongjian , Huang Fuqiong , Ma Long , Yang Changyi , Shi Haoyu 
Published: September 2022

In situ stress is a natural phenomenon. According to the Mohr–Coulomb criterion, it is found that when the ratio of principal stress (the ratio of maximum principal stress to minimum principal stress) of crustal rock mass in a certain environment exceeds the critical value, the rock mass will change from an elastic state to a plastic state. This critical value is the extreme limit of the principal stress ratio, which is related to the cohesion and internal friction angle of rock mass, and the limit of the principal stress ratio in the shallow part is discrete. Although the principal stress of deep rock mass is large, the ratio limit is mainly related to the internal friction angle. The calculation results show that the principal stress ratio of deep rock mass is stable in a small range. By comparing and analyzing 574 groups of measured data, it is found that all the measured principal stress ratios are within the limit range of the theoretical ratio, which also shows the characteristics of shallow dispersion and deep stability, indicating that the theoretical analysis and the measured results are consistent with each other. In order to show the change process of in situ stress, a numerical model fitting plate motion is established, and the limits of the principal stress ratio in five periods in the past 500,000 years are compared. The results show that the maximum principal stress at measuring points at different depths shows a change law of “first increasing and then stabilizing.” In areas close to or exceeding the principal stress ratio, high shear strain zones appear in the rock mass, and the stress is released in the form of plastic failure or shear dislocation, making the main stress ratio finally stable between 6.0 and 8.0. Therefore, it is easy to judge the stability of regional strata by using the ratio of principal stress; the area with a small ratio of principal stress belongs to the area with good stability, and when the ratio of principal stress is close to the limit of the ratio, it is an unstable area. The measured data show that the area with a high ratio of principal stress is often the recent seismic activity area; therefore, the ratio of in situ stress may become a possible index for earthquake prediction.
Factors influencing the photodegradation of acid orange 8 by nitrocellulose membranes
Authors: Wu Li , Fu Jiwei , Song Baihui , Zhao Tongqian , Liu Hong , Li Xiaolin 
Published: September 2022

Nitrocellulose membranes (NCM) have broad application prospects in the field of organic wastewater treatment. In this research, acid orange 8 was used as the target pollutant, and the effects of factors, such as concentration, light intensity, anions, and cations, on the photodegradation of acid orange 8 were investigated under simulated sunlight by NCM. The results showed that the degradation rate constant of acid orange 8 in the NCM system was 1.94 × 10−3 min−1, which was 27.3 times that in the pure water. The photodegradation rate increases with decreasing concentration in the range of 20–120 μmol/L for acid orange 8. The photodegradation rate increased with increasing NCM area. The degradation effect of acid orange 8 increased with the increase of light intensity. Acidic conditions were favorable for the degradation of acid orange 8. The optimal conditions for photodegradation of acid orange 8 were the solution concentration of 20 μmol/L, membrane area of 17.35 cm2, light intensity of 481 μmol/(m2s), and pH value of 3.0. The effect of different components in water on the photodegradation of acid orange 8 was different. Ca2+, Mg2+, and NO3− could promote the photodegradation of acid orange 8, while CO32- could inhibit the photodegradation. The effect of degrading acid orange 8 by NCM under light conditions is obvious, which can provide a new method for the removal of acid orange 8 in wastewater.
The regulatory network of potential transcription factors and MiRNAs of mitochondria-related genes for sarcopenia
Authors: Fu Wanrui , Kadeer Guzailinuer , He Yaqi , Feng Ying 
Published: September 2022

Background: Mitochondrial dysfunction is a significant contributor to sarcopenia, but the mechanism remains unclear.Methods: In the present study, we downloaded GSE117525 and GSE8479 datasets from Gene Expression Omnibus (GEO), then the weighted correlation network analysis (WGCNA) was used to construct scale-free co-expression networks respectively. The key genes of aging muscle were obtained by overlapping key modules of two networks. Receiver operating characteristic (ROC) curve was drawn to explore the diagnostic efficacy of key genes. Finally, a transcription factor-key gene network was constructed based on ChEA3 platform and hTFtarget database, and a miRNA-key gene network was constructed using starBase and the multimiR R package.Results: The most positively or negatively correlated modules of the two datasets were identified, and genes related to oxidative phosphorylation and mitochondrial ribosomal proteins were identified as key genes. The diagnostic values were confirmed with ROC curves by self-verification (GSE117525 and GSE8479) and external verification (GSE47881). Then, Yin Yang 1 (YY1) was identified as the most important transcription factor of the transcription factor-key gene network. In addition, miRNAs related to key genes were also predicted.Conclusion: The findings of the present study provide a novel insight into the pathological mechanism of sarcopenia.
Vitamin D metabolism pathway polymorphisms are associated with efficacy and safety in patients under anti-PD-1 inhibitor therapy
Authors: Luo Jianquan , Chen Huiqing , Ma Fang , Xiao Chenlin , Sun Bao , Liu Yiping , Tang Haoneng , Yang Yue , Liu Wenhui , Luo Zhiying 
Published: September 2022

AimVitamin D (VitD) signaling has been increasingly investigated for its role in stimulating the innate and adaptive immune systems and suppressing inflammatory responses. Therefore, we examined the associations between VitD-related genetic polymorphisms, plasma 25-hydroxyvitamin D (25(OH)D), and the efficacy and safety of immune checkpoint inhibitors (ICIs).Patients and methodsA total of 13 single-nucleotide polymorphisms (SNPs) in VitD metabolic pathway genes were genotyped in 343 cancer patients receiving ICI treatment using the MassARRAY platform. In 65 patients, the associations between plasma 25(OH)D levels and ICI treatment outcomes were investigated further.ResultsWe found that the CYP24A1 rs6068816TT and rs2296241AA genotypes were significantly higher in patients who responded to ICIs. Furthermore, patients with higher plasma 25(OH)D levels had a better treatment response. The distribution of allele and genotype frequencies showed that three SNPs (rs10877012, rs2762934, and rs8018720) differed significantly between patients who had immune-related adverse events (irAEs) and those who did not. There was no statistically significant relationship between plasma 25(OH)D levels and the risk of irAEs.ConclusionIn summary, our findings showed that genetic variations in the VitD metabolism pathway were associated with ICI treatment outcomes, and VitD supplementation may be useful in improving ICI treatment efficacy.
Association of ventilator-free days with respiratory physiotherapy in critically ill patients with Coronavirus Disease 2019 (COVID-19) during the first pandemic wave. A propensity score-weighted analysis
Authors: Privitera Emilia , Gambazza Simone , Rossi Veronica , Santambrogio Martina , Binda Filippo , Tarello Davide , Caiffa Salvatore , Turrin Valentina , Casagrande Carolina , Battaglini Denise , Panigada Mauro , Fumagalli Roberto , Pelosi Paolo , Grasselli Giacomo 
Published: September 2022

BackgroundRespiratory physiotherapy is reported as safe and feasible in mechanically ventilated patients with severe Coronavirus Disease (COVID-19) admitted to Intensive Care Unit (ICU), but the short-term benefits remain unclear.MethodsWe performed a retrospective observational study in four ICUs in Northern Italy. All patients with COVID-19 admitted to ICU and under invasive mechanical ventilation (MV) between March 1st and May 30th, 2020, were enrolled into the study. Overlap weighting based on the propensity score was used to adjust for confounding in the comparison of patients who had or had not been treated by physiotherapists. The primary outcome was the number of days alive and ventilator-free (VFDs). The secondary outcomes were arterial partial pressure of oxygen (PaO2)/fraction of inspired oxygen (FiO2) ratio (P/F) at ICU discharge, ICU length of stay, ICU and hospital mortality, and survival at 90 days. The trial protocol was registered on clinicaltrials.gov (NCT 05067907).ResultsA total of 317 patients were included in the analysis. The median VFDs was 18 days [interquartile range (IQR) 10; 24] in patients performing physiotherapy and 21 days (IQR 0; 26) in the group without physiotherapy [incidence rate ratio (IRR) 0.86, 95% confidence interval (CI): 0.78; 0.95]. The chance of 0 VFDs was lower for patients treated by physiotherapists compared to those who were not [odds ratio (OR) = 0.36, 95% CI: 0.18–0.71]. Survival at 90 days was 96.0% in the physiotherapy group and 70.6% in patients not performing physiotherapy [hazard ratio (HR) = 0.14, 95% CI: 0.03–0.71]. Number of VFDs was not associated with body mass index (BMI), sex, or P/F at ICU admission for individuals with at least 1 day off the ventilator.ConclusionIn patients with COVID-19 admitted to ICU during the first pandemic wave and treated by physiotherapists, the number of days alive and free from MV was lower compared to patients who did not perform respiratory physiotherapy. Survival at 90 days in the physiotherapy group was greater compared to no physiotherapy. These findings may be the starting point for further investigation in this setting.
Prevalence of lower urinary tract symptoms, urinary incontinence and retention in Parkinson's disease: A systematic review and meta-analysis
Authors: Li Fang-Fei , Cui Yu-Sha , Yan Rui , Cao Shuang-Shuang , Feng Tao 
Published: September 2022

BackgroundLower urinary tract symptoms (LUTS) are common non-motor symptoms but are often overlooked in Parkinson's disease (PD). The prevalence of LUTS in PD is inconsistent among different studies.ObjectiveTo estimate the prevalence of LUTS, urinary incontinence, and urinary retention in PD patients, then, investigate potential sources of inconsistency in prevalence estimation.MethodsWe searched PubMed, EMBASE, and Web of Science databases from inception to May 2022. Studies reporting the prevalence of LUTS or LUTS subtypes in PD were included. Pooled prevalence of LUTS, LUTS subtypes, urinary incontinence, and urinary retention was calculated via random-effects models. Meta-regression and subgroup analyses were performed.ResultsOf 7,358 studies after duplicate removal, a total of 73 studies comprising 14,937 PD patients were included. The pooled prevalence of LUTS was 61% (95% CI 53–69; 27 studies; n = 5,179), while the pooled prevalence of storage symptoms and voiding symptoms was 59% (44–73; 9 studies; n = 798) and 24% (14–33; 11 studies; n = 886), respectively. The pooled prevalence of urinary incontinence, retention and post-void residual (PVR) volume ≥ 100 ml were 30% (95% CI 22–39; 21 studies; n = 6,054), 27% (17–37; 14 studies; n = 1,991), and 4% (1–7; 5 studies; n = 439), respectively. The prevalence of LUTS, urinary incontinence, or urinary retention was significantly associated with diagnostic methods.ConclusionLUTS and its subtypes present in a significant proportion of PD patients. It is necessary to use standardized and validated methods to detect and screen LUTS and its subtypes.Systematic review registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022311233, Identifier: CRD42022311233.
Anatomical features decide the atypical seizure manifestation of parahypothalamic hamartomas
Authors: Liu Chang , Hu Wenhan , Zhang Chao , Zheng Zhong , Yang Xiaoli , Wang Xiu , Mo Jiajie , Guo Zhihao , Shao Xiaoqiu , Zhang Kai 
Published: September 2022

BackgroundThe intrahypothalamic phenotype of hypothalamic hamartomas (HH) is associated with epilepsy, and the parahypothalamic phenotype usually leads to central precocious puberty but not neurological comorbidities or seizures. No study has confirmed the pathological role of parahypothalamic hamartomas in epileptogenesis, and the underlying mechanism is yet to be elucidated.ObjectiveWe aimed to investigate whether parahypothalamic hamartomas are intrinsically epileptogenic and elucidate the underlying pathway of epileptogenesis.MethodsWe reviewed 92 patients with HH-related epilepsy, categorized them by the classification system of Delalande and Fohlen, and further classified Type I (corresponding to parahypothalamic HH) into the following three groups based on the relationship between the lesion and mammillary bodies (MB): entirely invaded (Group 1), partially connected (Group 2), and not connected at all (Group 3). We examined different anatomical features with their relationship to clinical manifestations. Stereoelectroencephalography (SEEG) was implanted in both HH and extra-HH cortices in different groups to identify the epileptogenic zone. Corticocortical evoked potentials (CCEPs) were also used to determine the pathological correlation among different regions to determine the related epileptogenic network.ResultsA total of 13 patients presented with parahypothalamic HH and 10 (76.9%) presented with non-GS only, with late-onset age and normal cognitive development, which is different from classical clinical features. SEEG showed that HH is intrinsically epileptogenic in MB-involved parahypothalamic groups. No statistical difference was found in onset age (p= 0.213), and lesions horizontally oriented from the tuber cinereum without connection to MB were not involved in seizure genesis. CCEP indicated a pathological connection among HH, middle cingulate cortex, and insular cortex.ConclusionThe parahypothalamic HH can also cause epilepsy and is different from classic HH-related seizures, by non-GS only with the late-onset age and normal cognitive development. MB is proven to be related to non-GS by the mamillo-cingulate-cortex pathway.
The relationship between religious/spiritual well-being, psychiatric symptoms and addictive behaviors among young adults during the COVID-19-pandemic
Authors: Vuzic Xenia D. , Burkart Pauline L. , Wenzl Magdalena , Fuchshuber Jürgen , Unterrainer Human-Friedrich 
Published: September 2022

BackgroundIt is becoming increasingly apparent that the COVID-19 pandemic not only poses risks to physical health, but that it also might lead to a global mental health crisis, making the exploration of protective factors for mental well-being highly relevant. The present study seeks to investigate religious/spiritual well-being (RSWB) as a potential protective factor with regard to psychiatric symptom burden and addictive behavior.Materials and MethodsThe data was collected by conducting an online survey in the interim period between two national lockdowns with young adults (N = 306; age: 18–35) in Austria. The primary study variables were assessed through the Brief Symptom Inventory 18 (BSI-18; psychiatric symptom load), the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST; addictive behavior/addiction risk) and the Multidimensional Inventory for Religious/Spiritual Well-Being short version (MI-RSWB 12), with its sub-dimensions Hope (HO), Forgiveness (FO), General Religiosity (GR), and Connectedness (CO).ResultsWe observed HO and FO as substantial negative predictors of psychiatric symptom burden. With regard to addictive behavior, HO in particular but also GR seem to have a protective function. Furthermore, we found positive connections between CO, psychiatric symptom burden, and addictive behavior.ConclusionIn line with our assumptions, HO, FO and to a minor extent GR were confirmed as negative predictors regarding psychiatric symptom burden or addictive behavior in young adults, coping with the psychological threat of COVID-19 pandemic. These dimensions might be further considered as potential resources in clinical treatment. However, the positive prediction of mental illness parameters by increased feelings of CO could also be interpreted as an expression of exhaustion and alienation from the real world.
The association between functional status and physical pain with depressive symptoms after a stroke event: A cross-sectional analysis of the China Health and Retirement Longitudinal Study 2018
Authors: Zhao William Yang , Zhang Luwen , Wan Yingfeng , Chen Xiaoying , Jin Yinzi , Zhang Lin , Sum Grace , Katar Ameera , Song Lili , Anderson Craig S. 
Published: September 2022

BackgroundStroke is a major cause of mortality and long-term physical and cognitive impairment. This study aims to: (1) examine the prevalence of depressive symptoms, disability and pain among Chinese adults with stroke; (2) test the associations of functional limitations and body pain with occurrence of depressive symptoms; (3) investigate gender and urban-rural disparities in these associations.MethodsThis study utilized the data from the China Health and Retirement Longitudinal Study in 2018, involving 969 patients with stroke among 17,970 participants aged ≥ 45 years. Depressive symptoms were assessed using the 10-item Center for Epidemiologic Studies Depression (CES-D) Scale. We performed multivariable logistic regression models to estimate the associations between activities of daily life (ADL), instrumental activities of daily life (IADL) and pain with depressive symptoms.ResultsDepressive symptoms were found among 40.2% of stroke patients, with a higher prevalence in females (48.2%) than males (32.7%). Prevalence of ADL limitations, IADL limitations and pain among stroke patients were 39.2, 49.8 and 14.0%, respectively. ADL and IADL limitations and pain were more prevalent among females and residents in rural areas. Multivariable regression analyses showed a significant association between ADL limitation (OR = 1.535, 95% CI = 1.168, 2.018), IADL limitation (OR = 1.666, 95% CI = 1.260, 2.203) and pain (OR = 2.122, 95% CI = 1.466, 3.073) with depressive symptoms. Stratified analyses revealed stronger associations among urban residents. Females had a higher association of ADL and IADL with depressive symptoms but similar in that of pain to the males. The impact of ADL and IADL in male patients is higher than in females, but the impact of pain on depressive symptoms is higher in female patients.ConclusionDepressive symptoms are common amongst post-stroke patients in China and are significantly associated with functional disability and physical pain. Our findings have implications for practitioners on the early assessment of pain and depression after stroke. Future research should explore effective intervention measures for physical-mental stroke complications.
Development and validation of a prognostic nomogram for adult patients with renal sarcoma: A retrospective study based on the SEER database
Authors: Zhu Yongkun , Mao Weipu , Zhang Guangyuan , Sun Si , Tao Shuchun , Jiang Tiancheng , Wang Qingbo , Meng Yuan , Wu Jianping , Chen Ming 
Published: September 2022

BackgroundRenal sarcoma (RS) is rarely seen in clinical practice. The purpose of this study was to develop a prognostic nomogram model, which could predict the probability of overall survival (OS) and cancer-specific survival (CSS) in adult patients with RS.MethodsPatients diagnosed with RS were recruited from the SEER database between 2004 and 2015, and randomized to two cohorts: the training cohort and the validation cohort. Uni- and multivariate Cox regression analyses in the training cohort were used to screen independent prognostic factors for OS and CSS. Prognostic nomograms for OS and CSS were created separately for adult RS patients based on independent risk factors. The area under the receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA) were used to validate the nomograms.ResultsA total of 232 eligible patients were recruited, including 162 in the training cohort and 70 in the validation cohort. Sex, histological type, SEER stage, and surgery were independent prognostic factors for OS, while histological type, SEER stage, surgery, chemotherapy were independent prognostic factors for CSS. Based on the above independent prognostic factors, prognostic nomograms for OS and CSS were created respectively. In the training cohort, the AUCs of the nomograms for OS and CSS were 0.742 and 0.733, respectively. In the validation cohort, the AUCs of the nomograms for OS and CSS were 0.837 and 0.758, respectively. The calibration curves of the nomograms showed high consistencies between the predicted and actual survival rates. Finally, the DCA demonstrated that the nomograms in the wide high-risk threshold had a higher net benefit than the SEER stage.ConclusionA prognostic nomogram for renal sarcoma was created and validated for reliability and usefulness in our study, which assisted urologists in accurately assessing the prognosis of adult RS patients.