bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Struggle for Legitimacy: Christian Virgins in China from the Late Ming Dynasty to 1860
Authors: Li Yiyuchi 
Published: July 2022

Abstract
Christian virgins were frequently targeted in official crackdowns by Ming and Qing governments on church activities, during which officials taking a Confucianist stance placed pressure on Christian virgins by scandalizing and criminalizing their motivations for practicing celibacy as their refusal to marry was regarded as a violation of Confucian morals. The legitimacy of Christian virgins depended on whether they were able to portray themselves as an “acceptable” type of celibate women within the Confucian patriarchal framework and the legal system of the Ming and Qing governments. During their interactions with the authorities, Christian virgins invoked pre-existing categories of chaste women that were accepted in the Confucian discourse on family order, such as “virgin widows” and “filial virgins,” to justify their way of life against attempts to criminalize their behavior. They also reaffirmed their affiliation to their patriarchal families through their everyday activities, constructing a positive self-image of themselves in stark contrast to the negative image presented by the anti-Christian literati. By adopting this strategy, they were more able to avoid external interference from the government in their religious life while remaining under the patronage of their natal family; however, the protection of their patriarchal family lost its efficacy once their acts were perceived as a direct political threat.
Catholicism in the Late Ming Dynasty and Ledgers of Merit and Demerit from the Perspective of Weber’s Sociology of Religion
Authors: Shao Tiefeng 
Published: July 2022

Abstract
According to Weber’s sociology of religion, Catholic moral book-keeping exhibits a tendency to offset merit with demerit, while that of Puritanism reflects a systematic and rational formation of a believer’s ethical life. This paper aims to prove that this distinction of Weber’s could be used to explain the tension between Catholicism in the late Ming dynasty and the traditional Chinese ledgers of merit and demerit at that time. Catholicism in the late Ming regarded the practice of keeping ledgers as representing not knowing God, leading to arithmetical moral practices that could undermine the purity of morality. Instead, what it required of its believers was a constant confession that enabled them to form a systematic self-examination and practice. This self-understanding of Catholicism is consistent with Weber’s interpretation of the Jesuit methodology of salvation.
From “Here” to Persia: The Place of Authorship of the Ancient Chinese Christian Manuscript Yishen Lun (Discourse on God)
Authors: Tam David 
Published: July 2022

Abstract
The seventh century Chinese Christian manuscript Yishen lun (Discourse on God) is not what Jingjiao scholarship has said it is, i.e., an Aluoben document composed in Chang’an. This article explains why and examines information available in the text, including the political and social structure of the place of authorship, unusual terms such as zuoren, gǒu and dié, and localization details such as the fabric used for Jesus’ burial and the modification of analogies, and arrives at the conclusion that it was written in the Xiyu (Western Region), at a place such as Gaochang (Turfan). Similarity in language between Yishen lun and other manuscripts from Dunhuang and Turfan also lends support to this view.
Combining Cloud Properties from CALIPSO, CloudSat, and MODIS for Top-of-Atmosphere (TOA) Shortwave Broadband Irradiance Computations: Impact of Cloud Vertical Profiles
Authors: Ham Seung-Hee , Kato Seiji , Rose Fred G. , Sun-Mack Sunny , Chen Yan , Miller Walter F. , Scott Ryan C. 
Published: July 2022

Abstract
Cloud vertical profile measurements from the CALIPSO and CloudSat active sensors are used to improve top-of-atmosphere (TOA) shortwave (SW) broadband (BB) irradiance computations. The active sensor measurements, which occasionally miss parts of the cloud columns because of the full attenuation of sensor signals, surface clutter, or insensitivity to a certain range of cloud particle sizes, are adjusted using column-integrated cloud optical depth derived from the passive MODIS sensor. Specifically, we consider two steps in generating cloud profiles from multiple sensors for irradiance computations. First, cloud extinction coefficient and cloud effective radius (CER) profiles are merged using available active and passive measurements. Second, the merged cloud extinction profiles are constrained by the MODIS visible scaled cloud optical depth, defined as a visible cloud optical depth multiplied by (1 − asymmetry parameter), to compensate for missing cloud parts by active sensors. It is shown that the multisensor-combined cloud profiles significantly reduce positive TOA SW BB biases, relative to those with MODIS-derived cloud properties only. The improvement is more pronounced for optically thick clouds, where MODIS ice CER is largely underestimated. Within the SW BB (0.18–4 μm), the 1.04–1.90-μm spectral region is mainly affected by the CER, where both the cloud absorption and solar incoming irradiance are considerable.

Significance Statement
The purpose of this study is to improve shortwave irradiance computations at the top of the atmosphere by using combined cloud properties from active and passive sensor measurements. Relative to the simulation results with passive sensor cloud measurements only, the combined cloud profiles provide more accurate shortwave simulation results. This is achieved by more realistic profiles of cloud extinction coefficient and cloud particle effective radius. The benefit is pronounced for optically thick clouds composed of large ice particles.
An Interdecadal Enhancement of the Impact of ENSO on the Summer Northeast Asian Circulation around 1999/2000 through the Silk Road Pattern
Authors: Yang Xianke , Huang Ping , Liu Yong , Chen Dong 
Published: July 2022

Abstract
In this study, we find that the negative relationship between El Niño–Southern Oscillation (ENSO) and summer Northeast Asia (NEA; 30°–50°N, 110°–140°E) circulation, especially the geopotential height anomalies in the upper troposphere (H200), is weakened from the early 1970s, remains stable since the middle 1980s, and is strengthened dramatically after 1999/2000. The recent transitions of the ENSO–NEA H200 relationship are closely connected with the variation of circumglobal teleconnection (CGT)/Silk Road pattern (SRP), which is further modified by the interdecadal shift of the ENSO–Indian summer monsoon rainfall (ISMR) relationship and ENSO evolution. During 1980–99 when the continuing ENSOs dominate, the weakened ENSO–ISMR relationship leads to an inactive ENSO-related CGT/SRP wave train in the upper-level troposphere and then a weakened connection between ENSO and H200 over the NEA. On the other hand, when the emerging ENSOs dominate after 1999/2000, the restored ENSO–ISMR relationship reinforces the ENSO-related CGT/SRP wave train and then enhances ENSO–NEA H200 relationship. This mechanism is well simulated in the Atmospheric Model Intercomparison Project models (AMIP) and Pacific Ocean–Global Atmosphere (POGA) experiments.
Lake Victoria Thunderstorms: Radar-Observed Initiation and Storm Evolution Modes
Authors: Wilson James , Roberts Rita D. 
Published: July 2022

Abstract
The enhanced observation period during the HIGHWAY field campaign in East Africa provided the opportunity to obtain continuous ground-based radar observations over the Lake Victoria basin. This provided insight into thunderstorm initiation processes and thunderstorm evolution. This insight is significant for it can lead to nowcasting thunderstorms over Lake Victoria, which is particularly important because of the >200 000 fishers using the lake daily and the extremely high number of drownings resulting from capsized boats caused by large waves and high winds from thunderstorms. Radar data from the south shoreline of Lake Victoria made it possible to observe thunderstorm activity over the entire lake. Unexpectedly the radar returns from high concentration of insects over the lake made it possible for the radar to observe boundary layer convergence lines. With this information a radar-trained forecaster could provide nowcasts of severe storm locations and by using extrapolation techniques provide nowcasts of their future location. In addition, rules for forecasting the timing and extent of nighttime thunderstorm activity over the lake based on radar monitoring of earlier activity along the northeast land/lake region are provided. While there are many obstacles to overcome, it is hoped that in the near future this possible life-saving information can be provided to Lake Victoria boaters.

Significance Statement
Radar data from the south shore of Lake Victoria has enabled new understanding of thunderstorm initiation and evolution over the lake. This understanding provides the potential to nowcast thunderstorms over Lake Victoria. This is particularly important because of the extremely high number of drownings that occur over the lake that result from capsized boats caused by large waves and high winds from thunderstorms. Radar-based rules are provided for forecasting and nowcasting the timing and severity of Lake Victoria thunderstorms.
GPCR genes as a predictor of glioma severity and clinical outcome
Authors: Ko Eun-A , Zhou Tong 
Published: July 2022

Objective To undertake a comprehensive analysis of the differential expression of the G protein-coupled receptor ( GPCR) genes in order to construct a GPCR gene signature for human glioma prognosis. Methods This current study investigated several glioma transcriptomic datasets and identified the GPCR genes potentially associated with glioma severity. Results A gene signature comprising 13 GPCR genes (nine upregulated and four downregulated genes in high-grade glioma) was developed. The predictive power of the 13-gene signature was tested in two validation cohorts and a strong positive correlation (Spearman’s rank correlation test: ρ =  0.649 for the Validation1 cohort; ρ = 0.693 for the Validation2 cohort) was observed between the glioma grade and 13-gene based severity score in both cohorts. The 13-gene signature was also predictive of glioma prognosis based on Kaplan–Meier survival curve analyses and Cox proportional hazard regression analysis in four cohorts of patients with glioma. Conclusions Knowledge of GPCR gene expression in glioma may help researchers gain a better understanding of the pathogenesis of high-grade glioma. Further studies are needed to validate the association between these GPCR genes and glioma pathogenesis.
Conflicting Working Relationships Among Nurses: The Intersection of Should Nursing, Double Domination, and the Big Picture
Authors: Rauman Peggy Ann 
Published: July 2022

Background Research conducted on conflict between Registered Nurses (RNs) has established that it happens regularly within the hospital setting, that it adversely affects the health and well-being of RNs, impacts the effective functioning of the health care organization, and compromises quality patient care. In this article, the phrase conflicting working relationships (CWRs) is used to represent working relationships between RN peers that are non-collegial, uncaring, and non- supportive, and inclusive of the behaviours associated with incivility, horizontal violence, and bullying, among others. Purpose To examine how nursing, including nursing knowledge and practice, is socially organized within the hospital setting and how this organization is linked to CWRs between RN peers. Methods Interviews were conducted with 17 RNs, followed by text analysis and mapping guided by institutional ethnography (IE) as the research methodology. Results The intersections between should nursing, double domination, and the big picture threads shows work environments where RNs struggle to provide appropriate care and conflict has become institutionalized. The intersection between threads can be used as caution areas for RNs and individuals in leadership positions to reflect on nursing practice when conflict is being experienced. Conclusions The contextual variables surrounding professional nursing practice are very influential with respect to how RNs relate to each other. A new type of dialogue about the organization of nursing practice in the hospital setting is needed to support more relational practices between RNs.
Intranasal Use of Prescription Stimulants Among Adults Aged 18 to 30: Results From A Crowdsourcing Platform
Authors: Vosburg Suzanne K. , Faraone Stephen V. , Riley Elizabeth , Whitaker Timothy , Kardish Jessica , Baker David , Kollins Scott H. , Rush Craig R. 
Published: July 2022

Objective: Few studies of prescription stimulant non-oral, non-medical use (NMU) (defined by use not as prescribed) have been conducted in adults beyond the college population. The purpose of this study was to characterize prescription stimulant non-oral use, specifically intranasal (IN) use (snorting) in young adults. Method: Amazon’s MTurk platform was used to recruit participants for an online survey. Data were collected from March to April 2020. Results: Thirty-two percent ( n = 157) of survey respondents ( N = 975), aged 18 to 30, reported IN prescription stimulant use (average of 32.1 episodes of lifetime IN use). Adderall was the most-reported prescription stimulant used intranasally (89.2%). Most IN users (82%; n = 68) reported spending no more than 5 minutes tampering with prescription stimulants. Intranasal users said they would take the medication orally if unable to tamper or manipulate medication for IN use. Conclusion: These data help quantify a complex public health issue of ongoing IN use of prescription stimulants and suggest a potential role for manipulation-deterrent medications.
Permanent tissue damage in multiple sclerosis lesions is associated with reduced pre-lesion myelin and axon volume fractions
Authors: Tagge Ian J , Leppert Ilana R , Fetco Dumitru , Campbell Jennifer SW , Rudko David A , Brown Robert A , Stikov Nikola , Pike G Bruce , Giacomini Paul S , Arnold Douglas L , Narayanan Sridar 
Published: July 2022

Background: The use of advanced magnetic resonance imaging (MRI) techniques in MS research has led to new insights in lesion evolution and disease outcomes. It has not yet been determined if, or how, pre-lesional abnormalities in normal-appearing white matter (NAWM) relate to the long-term evolution of new lesions. Objective: To investigate the relationship between abnormalities in MRI measures of axonal and myelin volume fractions (AVF and MVF) in NAWM preceding development of black-hole (BH) and non-BH lesions in people with MS. Methods: We obtained magnetization transfer and diffusion MRI at 6-month intervals in patients with MS to estimate MVF and AVF during lesion evolution. Lesions were classified as either BH or non-BH on the final imaging visit using T1 maps. Results: Longitudinal data from 97 new T2 lesions from 9 participants were analyzed; 25 lesions in 8 participants were classified as BH 6–12 months after initial appearance. Pre-lesion MVF, AVF, and MVF/AVF were significantly lower, and T1 was significantly higher, in the lesions that later became BHs ( p < 0.001) compared to those that did not. No significant pre-lesion abnormalities were found in non-BH lesions ( p > 0.05). Conclusion: The present work demonstrated that pre-lesion abnormalities are associated with worse long-term lesion-level outcome.
Survival Status and Predictors of Mortality Among Low Birthweight Neonates Admitted in Amhara Region Referral Hospitals of Ethiopia: Retrospective Follow-Up Study
Authors: Kebede Belete Fenta , Genie Yalemtsehay Dagnaw , Aregawi Desta Hailu , Tadele Behafta Afera 
Published: July 2022

Background Being born with low birthweight is a major determinant of perinatal, neonatal, and infant survival. Even though low birthweight-related neonatal mortality is high, there is an information gap regarding the survival status of low birthweight neonates and their predictors of mortality in Ethiopia. Objective This study was conducted to assess the survival status and predictors of mortality among low birthweight neonates admitted to Amhara region referral hospitals in Ethiopia. Methods and Materials A retrospective follow-up study was conducted on randomly selected low birthweight neonates admitted to the Amhara region referral hospital between January 01-2017 and December 30-2018. Data were entered into Epi-data 4.4.2.1 and exported to Stata 14 for cleaning and analysis. A cox regression model was used to analyze the data. Tables, charts, and text were used to report the results. Results This study revealed that 35.2% of participants died with incidence rates of 37.86 per 1000 person-day observations (95%CI: 31.79-45.10). Sepsis (AHR:1.72(95% CI: 1.05-2.81), respiratory distress (AHR: 2.03 (95% CI:1.36-3.03), necrotizing enterocolitis (AHR: 2.47 (95% CI: 1.17-5.20), congenital anomalies (AHR:2.37 (95% CI: 1.36-4.13), extreme low birth weight (AHR:2.62 (95% CI:1.54-4.44) and prematurity (AHR: 2.55 (95% CI:1.10-5.92) were independent predictors of mortality. Conclusion Sepsis, respiratory distress, necrotizing enterocolitis, congenital anomalies, extremely low birth weight, and premature birth were the independent predictors of mortality. Therefore, it is better for all stakeholders to focus more on the early diagnosis and management of low birth weight neonates with the factors associated with mortality.
Effect of Antidepressants on Glucagon-Like Peptide-1 Receptor Agonist-Related Weight Loss
Authors: Durell Natalie , Franks Rachel , Coon Scott , Cowart Kevin , Carris Nicholas W. 
Published: July 2022

Background: Depression and obesity have a bidirectional relationship making the management of one, without the other, problematic. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a preferred medication class for diabetes and obesity treatment given their weight loss effect; however, it is not known how antidepressants impact this effect. Objective: To assess the impact of antidepressant use on GLP-1 RA-associated weight loss in patients with or without type 2 diabetes mellitus. Methods: This was a retrospective, propensity matched, cohort study conducted using TriNetX. The study identified patients initiating a GLP-1 RA being treated with citalopram/escitalopram, bupropion, or no antidepressant. Cohorts were propensity score matched to analyze the primary outcome of mean end-of-study (77-371 days) body weight. Results: An initial query identified 31 273 patients eligible for analysis (30 160 receiving no antidepressant, 311 receiving bupropion, and 802 receiving citalopram/escitalopram). After propensity score matching, the study found patients receiving citalopram/escitalopram were taking more antidiabetic therapies at baseline compared with patients not treated with an antidepressant. Patients in the antidepressant cohorts experienced less weight loss compared with their respective matched cohorts not receiving antidepressants (citalopram/escitalopram −0.73 kg versus −1.74 kg; bupropion −0.84 kg versus −3.46 kg). Only the bupropion cohort was significantly heavier at end-of-study versus the non-antidepressant cohort (108 kg versus 103 kg, P = 0.018). Conclusion and Relevance: Antidepressants may diminish the weight loss effect of GLP-1 RAs. Additional research is needed to assess whether all GLP-1 RAs are affected similarly and the optimal weight loss strategies in patients receiving antidiabetic therapy with comorbid depression.
Proteomic and phosphoproteomic measurements enhance ability to predict ex vivo drug response in AML
Authors: Gosline Sara J. C. , Tognon Cristina , Nestor Michael , Joshi Sunil , Modak Rucha , Damnernsawad Alisa , Posso Camilo , Moon Jamie , Hansen Joshua R. , Hutchinson-Bunch Chelsea , Pino James C. , Gritsenko Marina A. , Weitz Karl K. , Traer Elie , Tyner Jeffrey , Druker Brian , Agarwal Anupriya , Piehowski Paul , McDermott Jason E. , Rodland Karin 
Published: July 2022

AbstractAcute Myeloid Leukemia (AML) affects 20,000 patients in the US annually with a five-year survival rate of approximately 25%. One reason for the low survival rate is the high prevalence of clonal evolution that gives rise to heterogeneous sub-populations of leukemic cells with diverse mutation spectra, which eventually leads to disease relapse. This genetic heterogeneity drives the activation of complex signaling pathways that is reflected at the protein level. This diversity makes it difficult to treat AML with targeted therapy, requiring custom patient treatment protocols tailored to each individual’s leukemia. Toward this end, the Beat AML research program prospectively collected genomic and transcriptomic data from over 1000 AML patients and carried out ex vivo drug sensitivity assays to identify genomic signatures that could predict patient-specific drug responses. However, there are inherent weaknesses in using only genetic and transcriptomic measurements as surrogates of drug response, particularly the absence of direct information about phosphorylation-mediated signal transduction. As a member of the Clinical Proteomic Tumor Analysis Consortium, we have extended the molecular characterization of this cohort by collecting proteomic and phosphoproteomic measurements from a subset of these patient samples (38 in total) to evaluate the hypothesis that proteomic signatures can improve the ability to predict response to 26 drugs in AML ex vivo samples. In this work we describe our systematic, multi-omic approach to evaluate proteomic signatures of drug response and compare protein levels to other markers of drug response such as mutational patterns. We explore the nuances of this approach using two drugs that target key pathways activated in AML: quizartinib (FLT3) and trametinib (Ras/MEK), and show how patient-derived signatures can be interpreted biologically and validated in cell lines. In conclusion, this pilot study demonstrates strong promise for proteomics-based patient stratification to assess drug sensitivity in AML.
Isolated sternal fracture after low-energy trauma in a geriatric patient: a case report
Authors: Sairanen Joni J. , Arponen Otso 
Published: July 2022

Abstract
Background
Falls are a common cause of emergency department (ED) visits for the older population. If osteoporosis is present, even falls from standing height can lead to unusual fractures normally associated with high-energy trauma. In this report, we analyze a rare case of an isolated sternal fracture with an unusual mechanism of injury. Our discussion aims to improve care for older adults with fall-related fractures.

Case presentation
An 86-year-old female presented in the ED of our hospital with a complaint of chest pain. She recalled a fall at home the previous day and described how her fist was impacted between the floor and her chest. A physical examination revealed local tenderness in the mid-chest. A lateral chest x-ray indicated a sternal fracture, and a chest computed tomography scan ruled out concomitant injuries. There were no acute changes on her electrocardiogram (ECG). Conservative outpatient treatment was started, and referrals were made with a recommendation to initiate fall prevention measures and osteoporosis screening in primary health care.

Conclusions
Geriatric patients can present in the ED with a rare sternal fracture even after only a minor chest trauma. Appropriate imaging and an ECG are warranted to exclude life-threatening additional injuries. An in-depth physical examination and an understanding of the exact mechanism of injury are important to avoid missing fractures in unexpected locations. Modern ED physicians could have an important role in the secondary prevention of fall-related fractures for geriatric patients.