bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eight-Kilogramme Giant Mesenteric Cyst of Mullerian Origin: Case Report and Review of Literature
Authors: Leong Eugene , Lee James Wai Kit , Keh Christopher Hang Liang 
Published: July 2022

Abstract
Mesenteric cysts are a rare occurrence in clinical practice, and even fewer are found to be of Mullerian origin. Diagnosis of mesenteric cysts is typically based on clinical assessment and radiological imaging. Surgical excision remains the primary treatment option. We report a case of a 42-year-old lady presenting with a giant mesenteric cyst weighing eight kilogrammes and analgesia optimisation with local anaesthetic infusion after en-bloc surgical excision. We also review the current literature of this rare clinical entity.
Placental growth fActor Repeat sampling for Reduction of adverse perinatal Outcomes in women with suspecTed pre-eclampsia: study protocol for a randomised controlled trial (PARROT-2)
Authors: Hurrell Alice Elizabeth , Sparkes Jenie , Duhig Kate E , Seed Paul T , Myers Jenny , Battersby Cheryl , Clark Katherine , Green Marcus , Hunter Rachael M , Shennan Andrew H , Chappell Lucy C , Webster Louise M 
Published: July 2022

Abstract
BackgroundPre-eclampsia is a complex pregnancy disorder, characterised by new or worsening hypertension associated with multi-organ dysfunction. Adverse outcomes include eclampsia, liver rupture, stroke, pulmonary oedema, and acute kidney injury in the mother, and stillbirth, fetal growth restriction, and iatrogenic preterm delivery for the fetus. Angiogenic biomarkers, including placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1), have been identified as valuable biomarkers for preterm pre-eclampsia, accelerating diagnosis and reducing maternal adverse outcomes by risk stratification, with enhanced surveillance for high-risk women. PlGF-based testing for suspected preterm pre-eclampsia has been incorporated into national guidance. The role of repeat PlGF-based testing and its effect on maternal and perinatal adverse outcomes have yet to be evaluated.MethodsThe PARROT-2 trial is a multi-centre randomised controlled trial of repeat revealed PlGF-based testing compared to repeat concealed testing, in women presenting with suspected pre-eclampsia between 22+0 and 35+6 weeks’ gestation. The primary objective is to establish whether repeat PlGF-based testing decreases a composite of perinatal severe adverse outcomes (stillbirth, early neonatal death, or neonatal unit admission). All women prior to enrolment in the trial will have an initial revealed PlGF-based test. Repeat PlGF-based tests will be performed weekly or two-weekly, depending on the initial PlGF-based test result, with results randomised to revealed or concealed.DiscussionNational guidance recommends that all women presenting with suspected preterm pre-eclampsia should have a single PlGF-based test when disease is first suspected, to help rule out pre-eclampsia. Clinical and cost effectiveness of repeat PlGF-based testing has yet to be investigated. This trial aims to address whether repeat PlGF-based testing reduces severe maternal and perinatal adverse outcomes and whether repeat testing is cost-effective. RegistrationISRCTN 85912420. Registered on 25 November 2019.
Influence of Structural Parameters on Separation Performance of Gas-liquid Cyclone Separator for Hydraulic Oil Tank
Authors: Zhang Jin , Chen Dongjing , Lv Ruiqi , Li Ying , Chen Lijuan , Kong Xiangdong 
Published: July 2022

Abstract
Lightweight design of oil tank could improve the endurance, maneuverability and carrying capacity of mobile equipment. Cyclone separator is beneficial for the miniaturization and lightweight design of hydraulic tank due to high separation efficiency. Structural parameters are essential for separation performance. The influence of five key parameters was studied by the orthogonal experiment method. Three assessment indexes, gas-liquid separation efficiency γ, overflow split ratio β and effective split ratio α, of the separation performance of the flow separator were proposed. The best optimal structure in orthogonal experiment was selected for verification experiment. The overflow split ratio of the cyclone was 15.8% and the separation efficiency reached 95.95%. The influence of five parameters on three indexes basically has same trend. The study provides a reference for the structure design and separation performance evaluation of the gas-liquid cyclone separator.
CSP Ⅰ-plus modified rEndostatin inhibits hepatocellular carcinoma metastasis via down-regulation of VEGFA and integrinβ1
Authors: Chen Xueqin , Wang Yan , Liu Hancong , Zhang Jingjing , Wang Jie , Jin Xiaobao , Ma Yan 
Published: July 2022

Abstract
Background
In our previous study, N end of the Circumsporozoite protein (CSP I-plus) modified recombinant human Endostatin (rEndostatin, endostar) (rES-CSP) was constructed, which had antiangiogenic capability and bound to hepatocellular carcinoma in vivo and in vitro. In this study, the inhibition of rES-CSP on hepatocellular carcinoma metastasis was verified in vivo and in vitro, and its possible mechanism was explored.
Methods
Firstly, the impact of rES-CSP on the migration, adhesion of hepatoma cell HCCLM3 was identified by wound healing, transwell, and on metastasis of orthotopic xenograft model was identified in nude mouse. Then the expression of metastasis-associated molecules (MMP2, E-cadherin, integrinβ1) and angiogenesis-related factors (VEGFA) in vitro and in vivo were detected by real-time PCR, western blotting, immunohistochemistry.
Results
Finally, we found that rES-CSP could inhibit the migration and invasion of HCCLM3, and decrease tumor metastasis and growth in nude mouse orthotopic xenograft models.The tumor inhibiting rates of rES-CSP and Endostar were 42.46 ± 5.39% and 11.1 ± 1.88%. The lung metastasis rates of the control, Endostar and rES-CSP were 71%, 50%, and 42.8%, respectively. Compared with Endostar, rES-CSP significantly down-regulated the expression of VEGFA and integrinβ1. Heparin, a competitive inhibitor of CSP I-plus, which can be bind to the highly-sulfated heparan sulfate proteoglycans (HSPGs) over-expressed in liver and hepatocellular carcinoma, alleviated the down-regulation of VEGFA and integrinβ1.
Conclusions
These indicate that rES-CSP may play a role in inhibiting tumor growth and metastasis by down-regulating the angiogenic factor VEGF and the metastasis-related molecules or by interfering with HSPGs-mediated tumor metastasis.
Commercial initiation of feather hydrolysate as supreme fertilizer: A smart bio-cleaning strategy of poultry waste
Authors: Sahoo Sumita , Dash Satyabrata , Rath Biswajit , Mondal Keshab C. , Mandal Arpita 
Published: July 2022

Abstract
Purpose
Economic development of India mainly depends on agricultural sectors. Indian traditional agricultural system is mainly based on chemical fertilizer to get better yield. The main motto of this research work is to change this traditional faith of Indian farmers and rural Indian economy.
Methods
Bioprocessing of feather prepared from an efficient newly isolated bacterial strain, identified as Bacillus wiedmanni SAB10 used to produce a nitrogen rich liquid fertilizer. The cell-free hydrolysate was prepared from submerged fermentation of poultry litter (1.25%, w/v) as sole media with supplemented as chicken feather (1%, w/v) in 79.41 hrs with pH 10.6.
Results
Fermented hydrolysate contains a significant quantity of total amino acid (503.02 mg/L) with diversity (Cystine, Phenylalanine, Tyrosine, lysine, Valine, Proline and Alanine), total oligopeptides (4.65 mg/ml) and thiol content (58.09 µg/ml) which influence growth and yield (1.02 fold) of moong beans (Vigna radiata) plant in pot trials and as well as successfully scale up in field trials by the farmers. This liquid fertilizer not only makes plant healthy and has drought tolerance (proline content- 0.023 mg/g) capacity but also increases the grain quality by spraying the fertilizer on foliage with ratio of 2:1 (Water: Feather hydrolysate) for two times (before the 1st flash and 2nd flash of flowering).
Conclusion
Fermented feather hydrolysate is used full as foliage fertilizer for the cultivation of moong beans. Some commercial properties and its eco-friendly, cost-effectiveness make it a smart liquid fertilizer in near future.
Exploitation of liquid CO2 based greener process for valorization of citronellal rich essential oils into flavor grade (-)-menthol using novel Sn/Al-B-NaYZE composites
Authors: Kumar Prashant , Chanotiya Chandan Singh , Bawitlung Laldingngheti , Yadav Anju , Kumar Pankaj , Pal Anirban , Shasany Ajit Kumar , Mohapatra Priyabrat , Rout Prasant Kumar 
Published: July 2022

Abstract
A two-step greener catalytic process has been developed for semi-synthesis of (-)-menthol from citronellal-rich essential oils such as Cymbopogon winterianus and Corymbia citriodora by using novel bi-acidic composites. These novel composites (Al-B-NaYZE or Sn-B-NaYZE) were prepared by impregnation of Sn-B and Al-B over NaYZE framework to increase the Lewis and Bronsted acidic sites. These composites were thoroughly characterized using TDP, FT-IR, UV, XRD, SEM, HRTEM, SA, and TGA. The composite Sn-B-NaYZE cyclized 99% of citronellal to isopulegol isomers with 99% selectivity in 45 min under liquid CO2 medium, while composite Al-B-NaYZE is showing 95% selectivity towards isopulegol isomers. Sn-B-NaYZE was displayed ehnaced selectivity due to its higher acidic property as confirmed by the TPD analysis. The chiral study indicates that the Sn-B-NaYZE composite is giving highest selectivity (94%) towards (-)-isopulegol. (+)-Citronellal or citronellal oil was found as an ideal substate for (-)-menthol production. It observed that Sn-B molar ratio over base material NaY-Zeolite was played a mojor role for catalytic activity and selectivity towards (-)-isopulegol. Further, isopulegol isomers were reduced to 98% of menthol using 1%Pd/AC at 40 psi H2 pressure in 1 h. Reaction mixture slowly frozen to -40oC for trouble-free isolation of the crude menthol. Further, pharmaceutical and flavor grade (-)-menthol was purified from the crude menthol through esterification process. This (-)-menthol was found to 100% biobased on 14C-radiocarbon-dating to authenticate as nature-identical. The composite has displayed high reusability up to five times without significant loss in their activity. After isolation of menthol, the spent oil was enrich with oxygenated monoterpenoids, hence it was displayed significant antimicrobial activities.
Towards Adversariality in Depth estimation based on local equilibrium disparity consensus and egomotion
Authors: MEKHZOUM Hamza , BOURJA Omar , ABDELALI Hamd AIT , DERROUZ Hatim 
Published: July 2022

Abstract
We ask whether Adversariality in left-right stereo images can learn toestimate an optimal depth map through a consensus-based loss func-tion and ego-motion. We describe the workow as merging supervisedlearning (AS) and unsupervised learning (U). The supervised learningmodel optimizes a depth estimation network with prior knowledge ofground-truth depth maps. Inspired by the recent works on adversarialneural networks, we formulate the supervised model as an adversariallearning task. Thus we generate two depth maps from left-right stereoimages, respectively. Based on their learning behavior{that is, the lossfunction, we take the then optimal depth map. On the contrary, the unsu-pervised learning module has no knowledge of the ground-truth depthyet optimizes the depth estimation network using 3D geometry. Ourframework is trained and benchmarked on the KITTI driving dataset.
Sociodemographic predictors of COVID-19 vaccine hesitancy and main reasons against the vaccines in eastern Oslo: A cross-sectional study
Authors: Steinmetz Lara 
Published: July 2022

Abstract
Background: Vaccines are an essential public health strategy to curb viral infection spreading and hinge on vaccine uptake which may be threatened by vaccine hesitant individuals. This study therefore aims to address sociodemographic predictors of vaccine hesitancy, main reasons for vaccine hesitancy, and how these reasons are explained by sociodemographic characteristics during the COVID-19 pandemic.Methods: A cross-sectional study (N = 5 442) was carried out in June 2021 among six eastern Oslo districts with high infection pressure. Sociodemographic variables included gender, age, country of birth, education, and household income. Binary logistic regression models were used to explore predictors of both vaccine hesitancy and specific reasons. Main reasons for vaccine hesitancy were assessed through descriptive statistics. Results: Vaccine hesitancy was overall low (5.8%). Findings stress the vulnerable position of younger age, participants born outside of Norway, lower education, and lower household income in relation to vaccine hesitancy proneness. Hesitancy was mainly grounded in confidence barriers such as fear of side effects (55.8%) and little experience with the vaccines (50.2%). Otherwise, complacency barriers such as not feeling to belong to a risk group (46.1%), not needing the vaccines (39.1%), and wanting the body to develop natural immunity (29.3%) were frequently present. Results indicated overall high trust in health authorities and professionals. Women and participants born in Norway were more likely hesitant due to a lack of confidence in the vaccines. Complacency barriers were less likely present among older age (60+) and participants born outside of Norway.Conclusions: Varying determinants of vaccine hesitancy and barrier trends among population groups emphasize the importance of clear public health communication about the risks, benefits, and importance of vaccines. Future studies with a larger sample should verify current findings and further explore the prevalence of convenience barriers. Norwegian health authorities should take these results into account and develop different public health strategies targeted at vulnerable population groups during the current and forthcoming pandemics to increase vaccine uptake and reach sufficient immunization.
Development of extrahepatic collateral circulation after endovascular therapy for post-pancreatectomy hemorrhage
Authors: Nozawa Yosuke , Yamazoe Shinji , Masuda koichi , Takigawa Yutaka , Kobashi Yuko , Ikeda Koshi , Fukuda Takeshi , Michimoto Kenkichi 
Published: July 2022

Abstract
Background
Endovascular therapy (ET) for delayed post-pancreatectomy hemorrhage (PPH) involves the risk of hepatic artery occlusion (HAO). Nonetheless, the development of extrahepatic collateral circulation (EHC) and relationship between radiological factors (EHC, portal vein stenosis, and HAO) and adverse hepatic events after ET remain unclear. This study aimed to evaluate the efficacy and safety of ET for delayed PPH and examine the development of EHC.
Methods
A total of 19 ET cases for delayed PPH were reviewed. Hepatic adverse events, portal vein stenosis, HAO, and mortality rate after ET were evaluated. Moreover, EHC from the left gastric artery (LGA), right inferior phrenic artery (RIPA), left inferior phrenic artery (LIPA), right internal thoracic artery (RITA), left internal thoracic artery (LITA), renal artery (RA), omental artery (OA), intercostal artery (IA), and branch of superior mesenteric artery (BSMA) was assessed using angiogram and computed tomography angiography (CTA).
Results
All cases were successfully treated using transcatheter arterial embolization (n = 17) and stent-graft placement (n = 2) without mortality. EHC from the LGA (8/19), RIPA (10/19), LIPA (4/19), and RITA (3/19) was observed on post-ET CTA. The incidence of hepatic adverse event was significant in the group with both HAO and portal vein stenosis (p < 0.001) and absence of EHC from LIPA and RITA (p < 0.05).
Conclusion
ET for delayed PPH might be effective and safe. While avoiding both HAO and portal vein stenosis is important, the development of EHCs from LIPA and RITA may prevent hepatic adverse events after ET.
Investigation of atypical cell parameter in the surveillance of patients with NMIBC; Initial outcomes of a single center prospective study
Authors: Karaburun Murat Can , Özkaya Mehmet Fatih , Ergüder Berrin İmge , Süer Evren 
Published: July 2022

Abstract
Objective: To investigate how well the Sysmex automated urine-analyzer's atypical-cell parameter can predict oncological outcomes when compared to cytology and pathology data in the follow-up of NMIBC patients.Material and Methods: We prospectively collected clinical data from 273 patients who underwent cystoscopic examination due to benign and malign reasons in our center between June 2020 and March 2021. Patients were divided into 2 groups.(Group-1:Patients with no previous diagnosis of bladder cancer(BC),Group-2:Patients with previously diagnosed NMIBC).The atypical-cell parameter was determined by studying the urine sample given by the patient for urinalysis. The atypical-cell parameter's sensitivity, specificity, negative predictive value(NPV), and positive predictive value(PPV) were assessed.Results: A total of 76(41.1%)patients underwent diagnostic procedures(Group-1) and remaining 109(58.9%)patients were NMIBC patients(Group-2) who subjected to control cystoscopy on follow-up. BC was detected in 70 patients, 28 of whom were newly diagnosed(Group-1). Remaining 42 patients had recurrence during their follow-up(Group-2).Atypical-cell values of 70 patients with BC were determined to be statistically significantly higher than those without malignancy.In Group-2, median atypical-cell values for those with no malignancy, those with low-grade BC reccurrence, and those with high-grade BC recurrence were 0.00(IQR:0.00-0.80), 0.25(IQR:0.10-1.10)and 1.20(IQR:0.70-2.15), respectively(p<0.001). For a cut-off of 0.1 atypical cells/μL,sensitivity and specificity were measured as 83.33% and 53.73%,respectively(AUC:0.727; p-value<0.0001).Conclusions: Atypical-cell parameter of the Sysmex-UF-5000 automated urine-analyzer is a newly introduced research parameter.The results of this study are promising.Based on our results, we presume that the atypical-cell parameter may be used in surveillance of the NMIBC patients.Multi-center studies with larger patient populations are required to prove its efficacy.
Identification and characterization of proteins that form the inner core Ixodes scapularis tick attachment cement layer
Authors: Mulenga Albert , Radulovic Zeljko , Porter Lindsay , Britten Taylor Hollman , Kim Tae Kwon , Tirloni Lucas , Gaithuma Alex Kiarie , Adeniyi-Ipadeola Grace O. , Dietrich Jolene K. , Moresco James J. , Yates John R. 
Published: July 2022

Abstract
Ixodes scapularis long-term blood feeding behavior is facilitated by a tick secreted bio adhesive (tick cement) that attaches tick mouthparts to skin tissue and prevents the host from dislodging the attached tick. Understanding tick cement formation is highly sought after as its disruption will prevent tick feeding. This study describes proteins that form the inner core layer of I. scapularis tick cement as disrupting these proteins will likely stop formation of the outer cortical layer. The inner core cement layer completes formation by 24 h of tick attachment. Thus, we used laser-capture microdissection to isolate cement from cryosections of 6 h and 24 h tick attachment sites and to distinguish between early and late inner core cement proteins. LC-MS/MS analysis identified 138 tick cement proteins (TCPs) of which 37 and 35 were unique in cement of 6 and 24 h attached ticks respectively. We grouped TCPs in 14 functional categories: cuticular protein (16%), tick specific proteins of unknown function, cytoskeletal proteins, and enzymes (13% each), enzymes (10%), antioxidant, glycine rich, scaffolding, heat shock, histone, histamine binding, proteases and protease inhibitors, and miscellaneous (3–6% each). Gene ontology analysis confirm that TCPs are enriched for bio adhesive properties. Our data offer insights into tick cement bonding patterns and set the foundation for understanding the molecular basis of I. scapularis tick cement formation.
“It made me feel part of the team, having my homework to do” – Women and specialist nurse experiences of remote follow up after ovarian cancer treatment: a qualitative interview study.
Authors: Kennedy Fiona , Shearsmith Leanne , Holmes Marie , Velikova Galina 
Published: July 2022

Abstract
Purpose. This study aimed to explore ovarian cancer patients’ and specialist nurses’ experiences of participating in a feasibility study of an electronic patient reported outcome (ePRO) follow-up pathway. Women in the feasibility study completed an ePRO questionnaire, had a blood test and telephone consultation with their specialist nurse, instead of face-to-face hospital visits.Methods. All women and the nurses involved were invited to take part in nested semi-structured interviews exploring all aspects of the pathway. Interviews were recorded and transcripts analysed using framework analysis.Results. Twenty interviews were conducted (16 out of 24 feasibility participants, and all 4 nurses involved). Four themes were identified: 1) readiness and motivators (e.g. feeling well), 2) practicalities and logistics (e.g. value of core features), 3) personal impact (e.g. connection and safety) and 4) future role. An underlying theme highlighted how women strived to seek reassurance and gain confidence. Most women and nurses were positive about the ePRO pathway and would happily continue using it. Conclusion. This work provides invaluable insight into the experiences of women on remote ePRO follow-up post-treatment. Important logistic and implementation issues were identified, which will inform future large-scale work to introduce and evaluate remote ePRO methods during cancer follow-up. This work highlights the key factors influencing women’s readiness and acceptability of an ePRO pathway, and how services should be carefully designed to ensure patients feel reassured and confident post-treatment. Further, it highlights that flexibility and patient preference should be considered in remote service delivery.Trial registration: ClinicalTrials.gov ID: NCT02847715 (first registered 19/05/2016)
Scope and Challenges of Incorporating Citizen Science into Indian Higher Education Institutions: A Case Study
Authors: PHARTYAL Shyam S. , Yadav Harsh 
Published: July 2022

Abstract
Citizen Science (CS) is gaining popularity among a section of the Indian Research Community as a potential cost-effective tool to generate and gather large-scale temporospatial-distributed research data with the help of non-scientist citizens ready to volunteer their free time for science and societal issues. However, CS activities in India seem confined to a few selected research disciplines at selected geolocations. This poses challenges and scope to incorporating CS into all Indian Higher Education Institutions (HEIs) as an experimental learning tool. We conducted a panIndia, online survey and assessed the scope and challenges of CS in Indian HEIs. The survey recorded the perception of all stockholders irrespective of their academic and professional background for four months, from January to May 2021. Survey results revealed explicit geographical and research discipline-wise biases in participants' acquaintance and preference for CS. Agriculture/Biodiversity/Ecology/Environment Science disciplines recorded around 67% of responses. More than two-thirds of respondents conveyed their interest in CS. However, they highlighted the lack of hand-on-experience and opportunity for formal training on CS at schools/university levels. The study emphasized the inclusion of the CS curriculum in the mainstream education system to train the next generation of researchers on several aspects of CS and tap its potential for large-scale research studies in all higher education disciplines.