bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preventing food waste in the Chinese catering supply chain：from a tacit knowledge viewpoint
Authors: Yu Ganqian , Li Fa , Chin Tachia , Fiano Fabio , Usai Antonio 
Published: February 2022

PurposeIn China food waste during the catering service process namely the back end of the entire food supply chain has neither received sufficient attention nor been evaluated precisely even though it has been the cause of food security concerns. In response considering the complex tacit knowledge embedded at the front end of the Chinese catering supply chain this article aimed at addressing relevant issues from the viewpoint of tacit knowledge.Design/Methodology/ApproachThis article is conceptual in nature. From the perspective of knowledge management (KM), we used a deductive method to explore intricate tacit knowledge embedded at the front end of the catering supply chain in China.FindingsThe key challenges in preventing food waste in the Chinese catering supply chains are: (1) a variety of knowledge icebergs in Chinese catering culture, (2) the complex tacit dimension of knowledge in Chinese cookery, and (3) difficulties in bringing standardization to the Chinese catering business. The three KM-based step-by-step solutions are: (1) standardizing the essential cookery techniques of Chinese cuisine, (2) encouraging catering enterprises to create online knowledge-sharing platforms to reduce food waste for all stakeholders, and (3) using big data to build a nationwide KM system.Practical ImplicationsOur research indicates that the of a comprehensive KM system specific to the Chinese catering supply chain is crucial for standardizing the essential cookery techniques of Chinese cuisine and analyzing big data, which could help improve Chinese catering processes and gastronomic habits in reality, so as to more effectively prevent food waste.Originality/ValueOur research contributes to the literature by connecting the reduction of food waste issues with the KM perspective. A key to more efficiently reducing food waste in China lies in the lack of a deeper, more systematic understanding of the tacit dimension of knowledge in Chinese cookery and impressive dietary culture, namely the front end of the catering supply chain.
Older adults’ experiences of social distancing and the role of the community center during COVID-19
Authors: Wolman Lauren , Atack Lynda , Khan Sanjana , Zwicker Sarah , Dela Cruz Czarielle , Roy Lisa , Arbeid Esther 
Published: February 2022

Purpose
Although very much needed from an infection control perspective, there is deep concern about the impact of social distancing during COVID-19, particularly on older adults.

Design/methodology/approach
A phenomenological design was used to gain insight into older adults’ experiences of living with social distancing during the first wave of COVID-19. Semi-structured interviews were conducted with eight older adults.

Findings
Six themes were identified: a smaller life, feelings of unease, resilience, connection to the community centre, technology: a boon, but one with limitations, and the way through social distancing.

Originality/value
This study captures older adults’ experiences early in COVID-19. Findings indicate that there is much we can learn from these older adults regarding social isolation that could apply to other older adults and potentially other age groups during the time of pandemic and beyond.
Disabled‐2 overexpression mediates immune suppression in systemic lupus erythematosus by modulating Treg/Th17 cell differentiation
Authors: Zhang Jing , Chang Lihua , Sun Yue , Qin Muting , Wang Xiaofei , Guo Yun 
Published: February 2022

AbstractSystemic lupus erythematosus (SLE) is an autoimmune disorder. T helper 17 (Th17) and regulatory T (Treg) cells play key roles in SLE progression. Disabled‐2 (DAB2) exhibits immunomodulatory effects in inflammatory diseases. However, the role of DAB2 in SLE and the precise mechanisms remain unknown. Here, a decreased DAB2 expression and an increased miR‐448‐3p level were observed in peripheral blood mononuclear cells (PBMCs) from SLE patients. DAB2 level was negatively correlated with SLE Disease Activity Index (SLEDAI), suggesting a functional correlation between DAB2 and SLE. To test this, we used 8‐week‐old MRL/lpr mice and treated them with lentivirus‐mediated DAB2 (LV‐DAB2) or its negative control (LV‐NC). LV‐DAB2 treatment increased DAB2 expression and reduced serum immunoglobulin G (IgG) and anti‐dsDNA IgG levels. DAB2 upregulation alleviated splenomegaly and lymphadenopathy and SLE‐related organ damage. Moreover, DAB2 enhanced the percentage of CD25+ Foxp3+ Treg cells, but reduced Th17 cell frequency in lupus, along with the reduction in tumour necrosis factor α (TNF‐α), interleukin (IL)‐6 (IL‐6) and IL‐17A levels, and the elevation in IL‐10. In vitro, naive CD4+ T cells isolated from MRL/lpr mice were polarized into Th17 or Treg phenotypes and treated with lentivirus. LV‐DAB2 treatment downregulated IL‐17A expression and inhibited the generation of CD4+ IL‐17A+ Th17 cells. DAB2 triggered the production of IL‐10 and the activation of Treg cells. Furthermore, DAB2 was verified as a direct target for miR‐448‐3p. MiR‐448‐3p overexpression cancelled the promoting effect of DAB2 on Treg cell differentiation. Taken together, DAB2 exerts an immunosuppressive effect on SLE through promoting Treg cell activation and inhibiting Th17 cell differentiation, which may be modulated by miR‐448‐3p.
Mapping the neurocircuitry of impulsive aggression through the pharmacologic review of anti‐impulsive aggressive agents
Authors: Nassif Joe Bou , Felthous Alan R. 
Published: February 2022

AbstractImpulsive aggression, in contradistinction to premeditated aggression in humans or predatory aggression in animals, corresponds to defensive aggression in animal models. At the core of the neurocircuitry of impulsive aggression, from murine to feline to human species, it is the medial amygdala‐mediobasal hypothalamus‐dorsal periaqueductal gray pathway. Here, we update current knowledge on the neurocircuitry of impulsive aggression by placing the neurocircuitry and its neurophysiological substrates into the top‐down/bottom‐up hypothesis of impulsive aggression. We then reverse the neurotranslational approach, which applies neuroscience to developing therapeutic drugs, and apply current understanding of potential mechanisms of anti‐impulsive aggression agents to further clarify, at least heuristically and hypothetically, the dynamic biochemical components of the neurocircuitry of impulsive aggression. To do this, we searched the medical literature for studies attempting to clarify the neurobiological and neurochemical effects of the five most widely studied anti‐impulsive aggressive agents, particularly as they pertain to the top‐down/bottom‐up hypothesis. Multiple different mechanisms are discussed, all of which fitting in the hypothesis by way of either promoting the “top‐down” part (i.e., enhancing inhibitory neurotransmitters), or suppressing the “bottom‐up” part (i.e., decreasing excitatory neurotransmitters). The hypothesis appears consistent with the current psychopharmacological understanding of these agents, as well as to account for the likely multifactorial etiology of the condition. Limitations of the hypothesis and future directions are finally discussed.
Complexation mechanism between 20(R, S)‐ginsenoside Rh1 and serum albumin: Multi‐spectroscopy, in vitro cytotoxicity, and in silico investigations
Authors: Zhao Jingqi , Liang Yuan , Zhu Ziyi , Wang Yingyi , Guan Tianzhu , Zhang Jie , Zhang Tiehua 
Published: February 2022

AbstractAs rare ginsenosides, 20(R, S)‐ginsenoside Rh1 [20(R, S)‐Rh1] are isomers and have been reported to exhibit multiple biological effects. However, the application of 20(R, S)‐Rh1 is still limited due to their poor solubilities and low bioavailabilities. Here, the complexation mechanism between 20(R, S)‐Rh1 and serum albumin (SA) was explored by a combination of multi‐spectroscopy and in silico investigations. Results of spectra experiments showed that 20(R, S)‐Rh1 could form complexes with bovine serum albumin (BSA) and quench its intrinsic fluorescence. In addition, the influence of BSA on the anti‐cancer activity of 20(R, S)‐Rh1 was also evaluated in A549 cells. The result of the MTT assay indicated that anti‐cancer activity of 20(R, S)‐Rh1 was enhanced when combined with BSA. The results of molecular docking and dynamics simulation demonstrated that the subtle structural differences of 20(R, S)‐Rh1 at the 20‐carbon atom may be responsible for their different binding capacities and binding stabilities with human serum albumin. The cytotoxicity assay for 20(R, S)‐Rh1 alone and their complexes with BSA demonstrated the enhancement effect of BSA for inhibition of cell proliferation. In conclusion, this work provided insight into the complexation mechanism between 20(R, S)‐Rh1 and SA.Practical ApplicationThe complexation mechanism between 20(R, S)‐ginsenoside Rh1 [20(R, S)‐Rh1] and serum albumin (SA) was explored by a combination of multi‐spectroscopy and in silico investigations in this work. The cytotoxicity assay for 20(R, S)‐Rh1 alone and their complexes with bovine serum albumin (BSA) demonstrates the enhancement effect of BSA for inhibition of cell proliferation. Hence, this work provided insight into the complexation mechanism between 20(R, S)‐Rh1 and SA.
Spiders and mushrooms: Reporting bowel endometriosis shape on preoperative MRI to flag surgical complexity
Authors: Youn Paul , Copson Sean , Jacques Angela , Haliczenko Kylie , McDonnell Rose , Lo Glen 
Published: February 2022

AbstractIntroductionPreoperative imaging of patients with endometriosis allows adequate counselling, referral to appropriate centres of expertise and workforce planning. The objective of this study was to assess the feasibility of simplified three‐category preoperative endometriosis MRI morphological descriptors to predict subsequent surgical management.MethodsA single‐centre observational study in 76 patients (median age 38 years, range 18–55) with preoperative endometriosis mapping MRI between 1 Jan 2015 and 31 Dec 2019. MRI studies were prospectively re‐read blind‐to‐surgical outcome to categorise rectosigmoid morphology as normal, spider‐shaped (linear T2‐dark fibrotic bands) superficial endometriosis or typical crescentic or mushroom‐shaped deep infiltrating endometriosis (DIE). Bowel motility was similarly categorised as normal, tethered or distorted/fixed. The reference standard was subsequent surgery within 3 years of MRI, categorised as no bowel surgery, adhesiolysis only or more complex surgeries.ResultsDespite three‐quarters of surgical cases having normal bowel morphology on preoperative MRI (72%, 55/76; 12% linear superficial endometriosis, 10% crescentic and 5% mushroom‐shaped DIE) more than half showed bowel tethering (54%, 41/76) or distortion/fixation (10%, 8/76) and most patients underwent adhesiolysis (79%, 60/76). Complex surgery such as bowel resection, laparotomy conversion or complex adhesiolysis is predicted by morphology (crescentic or mushroom‐shaped DIE, P < 0.001) and motility (tethered or distorted bowel, P = 0.002) descriptors.ConclusionsComprehensive and clinically relevant diagnostic reporting does not have to be convoluted to have clinical impact: in our study population, categorising bowel morphology as normal, spider‐shaped (superficial) or crescentic/mushroom‐(DIE) shaped and motility as normal, tethered (superficial) or distorted/fixed (deep endometriosis) correlates to subsequent surgical complexity.
On young Turks and yes men: optimal contracting for advice
Authors: Häfner Samuel , Taylor Curtis R. 
Published: February 2022

AbstractWe study contracting for advice by an agent about how much a principal should invest in a project. Providing the agent with incentives to perform research endogenously generates incentives for her to misreport the results. For high‐cost (low‐cost) projects, she wishes to overstate (understate) the magnitude—though not the direction—of her research findings. For high‐cost projects, the principal mitigates the concomitant agency rents by committing to ignore extreme (Young‐Turk) recommendations, whereas for low‐cost projects, he ignores mild (Yes‐Man) ones. These results are shown to be robust to several natural extensions of the model.
Complete genome assembly of the levan‐positive strain PVFi1 of Pseudomonas savastanoi pv. savastanoi isolated from olive knots in Central Italy
Authors: Turco Silvia , Drais Mounira Inas , Rossini Luca , Chaboteaux Elena , Rahi Yaseen Jundi , Balestra Giorgio Mariano , Iacobellis Nicola Sante , Mazzaglia Angelo 
Published: February 2022

SummaryPseudomonas savastanoi pv. savastanoi, the causal agent of olive knot disease, is a fluorescent Gram‐negative bacterium classified, according to the specific LOPAT profile, as Ib. However, during the 90s, a number of atypical non‐fluorescent levan‐positive strains of Pseudomonas savastanoi pv. savastanoi have been unexpectedly isolated from olive knots in Central Italy. Since its first report, several studies were conducted on this species variant, but its genome sequence has never been reported. The complete genome sequence and two additional plasmids of PVFi1, a representative strain, were here obtained using a hybrid sequencing approach with both Oxford Nanopore Technology and Illumina sequencing. A thorough genomic analysis unravelled several genetic features of this peculiar strain, showing a transposase insertion downstream a fragmented copy of the levansucrase gene. The same features were previously reported on levan‐negative Pseudomonas savastanoi pv. savastanoi strains. In addition, a second copy of the levansucrase gene fully equipped for a gene expression and comparable to the levan‐positive Pseudomonas savastanoi pv. glycinea, may explain the levan‐positive test. This result provides a solid genetic demonstration that the bacterial species Pseudomonas savastanoi contains either levan‐positive or levan‐negative strains, providing insights for an update of the related LOPAT classification.
Postoperative radiotherapy for patients with completely resected stage IIIA‐N2 non‐small cell lung cancer: opt‐in or opt‐out
Authors: Zhu Lucheng , Xia Bing , Ma Shenglin 
Published: February 2022

AbstractThe role of adjuvant radiotherapy in completely resected pIIIA‐N2 non‐small cell lung cancer (NSCLC) has long been debated. Evidence from previous retrospective and prospective studies showed that postoperative radiotherapy could reduce the incidence of local recurrence and prolong disease‐free survival, while two recently reported randomized controlled trials (lung ART and PORT‐C) both demonstrated no survival benefit of postoperative radiotherapy. The great gap between our knowledge and reality has made us rethink the value of postoperative radiotherapy. In this mini review, we elaborate on the role of postoperative radiotherapy in completely resected pIIIA‐N2 NSCLC.
Recurrent esophageal adenocarcinoma derived from ectopic gastric mucosa: A case report
Authors: Kitasaki Nao , Hamai Yoichi , Yoshikawa Toru , Emi Manabu , Kurokawa Tomoaki , Hirohata Ryosuke , Ohsawa Manato , Okada Morihito 
Published: February 2022

AbstractMost primary esophageal adenocarcinomas arise from the Barrett epithelium of the distal esophagus. Thus, cancer developing from the ectopic gastric mucosa (EGM) of the proximal esophagus is extremely rare. Furthermore, recurrent adenocarcinoma at the EGM has not been reported. Here, we describe adenocarcinoma originating from the EGM at the boundary of the cervical and thoracic esophagus that recurred twice at the same site within 40 months. This adenocarcinoma was treated throughout its course by three endoscopic submucosal dissections and a subsequent thoracoscopic esophagectomy. This is the first description of recurrent adenocarcinoma originating from the EGM of the proximal esophagus.
Alcohol‐related stimuli modulate functional connectivity during response inhibition in young binge drinkers
Authors: Blanco‐Ramos Javier , Antón‐Toro Luis Fernando , Cadaveira Fernando , Doallo Sonia , Suárez‐Suárez Samuel , Rodríguez Holguín Socorro 
Published: February 2022

AbstractBinge drinking is a pattern of intermittent excessive alcohol consumption that is highly prevalent in young people. Neurocognitive dual‐process models have described substance abuse and adolescence risk behaviours as the result of an imbalance between an overactivated affective‐automatic system (related to motivational processing) and damaged and/or immature reflective system (related to cognitive control abilities). Previous studies have evaluated the reflective system of binge drinkers (BDs) through neutral response inhibition tasks and have reported anomalies in theta (4–8 Hz) and beta (12–30 Hz) bands. The present study aimed to investigate the influence of the motivational value of alcohol‐related stimuli on brain functional networks devoted to response inhibition in young BDs. Sixty eight BDs and 78 control participants performed a beverage Go/NoGo task while undergoing electrophysiological recording. Whole cortical brain functional connectivity (FC) was evaluated during successful response inhibition trials (NoGo). BDs exhibited fast‐beta and theta hyperconnectivity in regions related to cognitive control. These responses were modulated differently depending on the motivational content of the stimuli. The increased salience of alcohol‐related stimuli may lead to overactivation of the affective‐automatic system in BDs, and compensatory neural resources of the reflective system will thus be required during response inhibition. In BDs, inhibition of the response to alcohol stimuli may require higher theta FC to facilitate integration of information related to the task goal (withholding a response), while during inhibition of the response to no‐alcoholic stimuli, higher fast‐beta FC would allow to apply top‐down inhibitory control of the information related to the prepotent response.
Repeated low doses of LSD in healthy adults: A placebo‐controlled, dose–response study
Authors: de Wit Harriet , Molla Hanna M. , Bershad Anya , Bremmer Michael , Lee Royce 
Published: February 2022

AbstractThe resurgence of interest in using psychedelic drugs, including lysergic acid diethylamide (LSD), in psychiatry has drawn attention to the medically unsupervised practice of ‘microdosing’. Thousands of users claim that very low doses of LSD, taken at 3–4‐day intervals, improve mood and cognitive function., However, few controlled studies have described the effects of the drug when taken in this way. Here, in a double‐blind controlled study, we studied the effects of four repeated doses of LSD tartrate (13 or 26 μg) or placebo, administered to healthy adults at 3–4 day intervals, on mood, cognitive performance and responses to emotional tasks. Participants were randomly assigned to one of three drug conditions: placebo (N = 18), 13 μg LSD (N = 19), or 26 μg LSD (N = 19). They attended four 5‐hour drug‐administration sessions separated by 3–4 days, followed by a drug‐free follow‐up session 3–4 days after the last session. LSD (26 μg) produced modest subjective effects including increased ratings of ‘feeling a drug effect’ and both stimulant‐like and LSD‐like effects, but the drug did not improve mood or affect performance on psychomotor or most emotional tasks. No residual effects were detected on mood or task performance on the drug‐free follow‐up session. We conclude that within the context of a controlled setting and a limited number of administrations, repeated low doses of LSD are safe, but produce negligible changes in mood or cognition in healthy volunteers.
Does neighborhood matter? Spatial proximity and farmers’ technical efficiency
Authors: Tirkaso Wondmagegn , Hailu Atakelty 
Published: February 2022

AbstractThis article examines the effects of neighborhood on the farmer's technical efficiency (TE) level, adopting a stochastic frontier and spatial Durbin regression models. Our study exploits a three‐wave household‐level panel data from the Ethiopian Rural Socioeconomic Survey (ERSS) collected between 2011 and 2015. We find that farmers have an average TE score of 53%, implying a substantial potential for improvement in the production level. We further find that there is a positive and statistically significant spatial interdependence in TE levels between farms in neighboring communities. Input use, education, and other demographic characteristics are found to have significant positive direct and indirect effects. The findings suggest that policies and programs targeting productivity improvements in agriculture need to consider spatial spillover effects.
Listening To Jewish Missionaries’ Messages: Confronting the Ethnographic “Other” at Home
Authors: Shokeid Moshe 
Published: February 2022

SummaryThis article presents a vexing ethnographic project: investigating the efforts of Jewish missionaries to attract new followers—repentants—among non‐practicing Jews. Attending lectures and other activities offered by Jewish religious proponents, Arachim in Israel and Chabad in New York, I learned how they advocate the return of secular Jews to their ethnic‐cultural roots, emphasizing the Torah doctrine and the Halacha (Jewish law) rules of daily comportment. An analysis of their presentations highlights specific indoctrinating devices and communication strategies. The discussion raises the issue of moral judgment and ethnographic reporting impediments when the ethnographer confronts the “other” at home by conducting research among their fellow citizens.
A health action process approach for developing invitee endorsed interventions to increase mail‐out bowel cancer screening
Authors: Myers Larry , Goodwin Belinda , Ralph Nicholas , March Sonja 
Published: February 2022

AbstractTheory‐based, user‐informed interventions are needed to increase the low participation rates of population‐based faecal occult blood test (FOBT) bowel cancer screening. This study investigated the theoretical fit of the health action process approach (HAPA) for home FOBT screening and measured screening invitees' attitudes towards different intervention strategies. A cross‐sectional sample (n = 377), aged 50–74 years, participated in this study. Two scales were created for this study. The process approach to mail‐out screening (PAMS) scale measured HAPA constructs, and the user ratings of mail‐out screening interventions (UR‐MSI) scale measured attitudes towards different intervention strategies. Structural equation modelling was used to assess the fit of PAMS scale responses to the HAPA model, and descriptive statistics were calculated for UR‐MSI responses. PAMS results showed acceptable model fit, CFI = .968, RMSEA = .050 and explained 49.9% of the variation in FOBT screening participation. Positive ratings of interventions ranged from 20.47%, an intervention prompting planning to complete the FOBT kit, to 72.25%, an intervention promoting the positive health outcome associated with FOBT screening. Intervention strategies should be combined such that they target all factors specified within the HAPA model. User‐informed intervention design should be used to effectively facilitate FOBT uptake in the community.