bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic characterization of downy mildew resistance from the hop (Humulus lupulus L.) line USDA 64035M
Authors: Olatoye Marcus O. , Wiseman Michele , Gent David H. , Henning John A. , Altendorf Kayla R. 
Published: November 2022

AbstractDowny mildew (caused by Pseudoperonospora humuli) resistance (DMR) will facilitate the success of hop (Humulus lupulus L.) production in humid, temperate climates. However, DMR in hop has a narrow genetic base, and its genetic architecture is poorly understood. In this study, we characterized the genetic control of DMR using a biparental mapping population derived from a cross between a female, the susceptible cultivar ‘Comet,’ and a male plant, the resistant line USDA 64035M. Resistance was evaluated after inoculation with the downy mildew pathogen as disease severity and percent leaf area with sporulating lesions under greenhouse conditions. Significant (p value < 0.01) genotypic differences were observed for the traits. Broad‐sense heritability was 0.33 for disease severity and 0.72 for percent leaf area with sporulating lesions. Genome–phenome association between 4090 markers and 274 individuals identified three significant markers for disease severity and five for percent leaf area with sporulating lesions. Our study demonstrated that DMR was under polygenic control with small effect loci in this population. In addition, a pleiotropic locus on chromosome two was found to be associated with both disease severity and percent leaf area with sporulating lesions. Identifying the gene(s) underlying such a pleiotropic locus can help improve our understanding of hop response to pathogen infection.
Use‐oriented business model
Authors: Nyvall Moa , Zobel Thomas , Mark‐Herbert Cecilia 
Published: November 2022

AbstractIn a world of sustainability challenges, use‐oriented product‐service system seems promising to encourage resource efficiency. For this project, the concept is integrated in a sustainability‐oriented interpretation of the business model Canvas. The aim was to identify enabling factors with a use‐oriented business model. A case study was conducted on rental business models in the outdoors apparel industry in Scandinavia. The key findings indicate that companies introducing use‐oriented services struggle with increased transportation, linear technological systems, large financial capital needs and cultural barriers. To overcome these challenges the case study points to the importance of partnerships. Furthermore, this paper suggests expanding the Business Model Canvas framework with three additional elements: reduced material flows, reverse logistics and cultural adoption factor. The extended Canvas model can be used as a conceptual tool for companies when developing rental services.
Circulating CD22+/CD19−/CD24− progenitors and CD22+/CD19+/CD24− mature B cells: Diagnostic pitfalls for minimal residual disease detection in B‐lymphoblastic leukemia
Authors: Zhou Ting , Karrs Jeremiah , Ho Truc , Doverte Alyssa , Kochenderfer James N. , Shah Nirali N. , Yuan Constance M. , Wang Hao‐Wei 
Published: November 2022

AbstractBackgroundMultiparametric flow cytometry (MFC) has become a powerful tool in minimal residual disease (MRD) detection in B‐lymphoblastic leukemia/lymphoma (B‐ALL). In the setting of targeted immunotherapy, B‐ALL MRD detection often relies on alterative gating strategies, such as the utilization of CD22 and CD24. It is important to depict the full diversity of normal cell populations included in the alternative B‐cell gating methods to avoid false‐positive results. We describe two CD22‐positive non‐neoplastic cell populations in the peripheral blood (PB), including one progenitor population of uncertain lineage and one mature B‐cell population, which are immunophenotypic mimics of B‐ALL.MethodsUsing MFC, we investigated the prevalence and phenotypic profiles of both CD22‐positive populations in 278 blood samples from 52 patients with B‐ALL; these were obtained pre‐ and post‐treatment with CD19 and/or CD22 CAR‐T therapies. We further assessed whether these two populations in the blood were exclusively associated with B‐ALL or recent anticancer therapies, by performing the same analysis on patients diagnosed with other hematological malignancies but in long‐term MRD remission.ResultsThe progenitor population and mature B‐cell population were detected at low levels in PB of 61.5% and 44.2% of B‐ALL patients, respectively. Both cell types showed distinctive and highly consistent antigen expression patterns that are reliably distinguishable from B‐ALL. Furthermore, their presence is not restricted solely to B‐ALL or recent therapy.ConclusionsOur findings aid in building a complete immunophenotypic profile of normal cell populations in PB, thereby preventing misdiagnosis of B‐ALL MRD and inappropriate management.
Pilot‐aided 1 × 2 and 2 × 2 space‐time line code systems with transmit antenna selection
Authors: Xu Hongjun , Pillay Narushan , Yang Fengfan 
Published: November 2022

SummaryThe space‐time line code (STLC), which has been recently proposed in the literature, assumes fully known channel state information at the transmitter and not the receiver. However, the effective channel gain is still required at the receiver to coherently detect
‐ary quadrature amplitude modulation (
QAM) symbols. In this paper, we propose pilot‐aided STLC systems, which do not require the effective channel gain at the receiver to detect the
QAM symbols. In order to further improve the error performance of the proposed schemes, we present the pilot‐aided STLC systems with transmit antenna selection (TAS). Using a more direct and simpler approach, we derive the average symbol error probability (ASEP) of the coherent
STLC systems with TAS, which represents the lower bound of the pilot‐aided
STLC systems with TAS. For comparison, in a similar manner, we also derive the ASEP of the coherent
STLC systems without TAS, which represents the lower bound of the pilot‐aided
STLC systems. For pilot‐aided
STLC systems with TAS, the gap between the simulated symbol error rate (SER) and the derived theoretical ASEP lower bound is very small. For a given number of transmit antennas, the simulated SER and theoretical ASEP also show that the error performance of the pilot‐aided
STLC systems with or without TAS is superior to the pilot‐aided
STLC systems with TAS by at least 1.8 dB.
Distinct T cell subsets in adipose tissue are associated with obesity
Authors: Haugstøyl Martha E. , Cornillet Martin , Strand Kristina , Stiglund Natalie , Sun Dan , Lawrence‐Archer Laurence , Hjellestad Iren D. , Sparrelid Ernesto , Busch Christian , Hjelmesæth Jøran , Hertel Jens K. , Ponzetta Andrea , Mellgren Gunnar , Fernø Johan , Björkström Niklas K. 
Published: November 2022

AbstractAdipose tissue inflammation is a driving factor for the development of obesity‐associated metabolic disturbances, and a role of adipose tissue T cells in initiating the pro‐inflammatory signaling is emerging. However, data on human adipose tissue T cells in obesity are limited, reflected by the lack of phenotypic markers to define tissue‐resident T cell subsets. In this study, we performed a deep characterization of T cells in blood and adipose tissue depots using multicolor flow cytometry and RNA sequencing. We identified distinct subsets of T cells associated with obesity expressing the activation markers, CD26 and CCR5, and obesity‐specific genes that are potentially engaged in activating pro‐inflammatory pathway, including ceramide signaling, autophagy, and IL‐6 signaling. These findings increase our knowledge on the heterogeneity of T cells in adipose tissue and on subsets that may play a role in obesity‐related pathogenesis.
Boron Catalysis in the Transformation of Carboxylic Acids and Carboxylic Acid Derivatives
Authors: Sawamura Masaya , Shimizu Yohei 
Published: November 2022

AbstractCarboxylic acids, amides, and esters are ubiquitous motifs in functional organic molecules. However, the reactivities of these high oxidation state carbonyl compounds are far lower than ketones and aldehydes, and catalysts applicable to transform this class of carbonyl compounds are limited. On the other hand, boron catalysts have found various applications in the transformation of carbonyl compounds by taking advantage of the unique properties derived from their vacantp‐orbitals. The continuous advancement of boron catalysis has realized several unprecedented direct transformations of carboxylic acids, amides, and esters in the past decade. In this review, representative achievements of boron catalysis are summarized according to reaction types by focusing on their applications to non‐activated carboxylic acids, amides, and esters.
Fabrication and stabilization of green nanosilver using gardenia yellow natural dyes for efficient degradation of bacteria
Authors: Jiang Huiyu , Guo Rui , Zhang Heng , Lü Shaofang , Mia Rony , Yang Feng , Mahmud Sakil , Liu Huihong 
Published: November 2022

AbstractThe various applications of silver nanoparticles (AgNPs) are brutally hampered in the practical field due to their instability and aggregation features. Thus, highly stable colloidal AgNPs were produced in obedience to the principle of ‘green chemistry’ that uses natural dyes extracted from gardenia fruits as stabilizing and simultaneously as reducing agents. The effect of operating conditions on the synthesis of AgNPs was studied using a one‐variable‐at‐a‐time technique to maximize the growth of particles. The analysis of AgNPs produced at optimum reaction parameters discovered that the particles are face‐centered cubic metallic silver, mostly in spherical shapes, nano‐ranged in diameter (23.4 ± 6.4 nm) with a confined size distribution, enormously crystalline surface (d‐spacing = 0.233 nm), firmly stabilized (zeta potential = −29.0 mV) by a thin membrane of gardenia phytochemicals. They exhibited significant bacterial reduction inhibition against the growth of Escherichia coli and Staphylococcus aureus owing to the strong antibacterial function of nanosilver.
Regenerative effect of pyramid solar still with incorporation of nickel oxide particles in the basin
Authors: Kavitha Sekar , Nagarajan Mony , Sengottaiyan Shanmugan 
Published: November 2022

AbstractA study has been conducted with a square pyramid solar still with an introduction of 5 wt% of nickel oxide nanoparticles in the basin water of depth 0.02 m. The ratio of condensing to evaporating surface has been fixed as 3.5 to increase the temperature difference for faster evaporation. In addition, regenerative effect for the system has been carried out by arranging to flow the water over the condensing surface with a rate of 1.5 × 10−3 kg/s to reduce the temperature of the condensing surface. The combined regenerative effect and increase in condensing to evaporative surface increases the productivity of 45% greater than the ordinary square pyramid solar still. It is found that, the daily average efficiency of 39.8916% with distillate yield of 5.6 L/m2 day has been obtained for the proposed system. Numerical results of the thermal are intact with the experimental observations and model is recommended for simulation of the system in the locations having similar climatic condition and for the optimization of design parameters of the still.
Attention bias modification add‐on to inpatient treatment for young women with anorexia nervosa—A randomized controlled trial
Authors: Dikstein Hadar , Gilon‐Mann Tal , Halevi‐Yosef Roni , Enoch‐Levi Adi , Hamdan Sami , Gur Eitan , Haim Yair Bar , Lazarov Amit , Treasure Janet , Stein Daniel 
Published: November 2022

AbstractPatients with anorexia nervosa (AN) display elevated anxiety and attention biases (ABs) in threat processing. Attention bias modification treatment (ABMT) is considered promising for anxiety disorders, but its potential for AN is limited. In this study, 154 young women hospitalised because of AN were assigned to ED‐related and anxiety‐related threat stimuli, or to a non‐ABMT intervention control condition in a randomized control trial. Hundred‐and‐ten patients completed the study. ABMT was an add‐on to the regular inpatient treatment. Research participants completed two pretreatment training sessions and eight biweekly sessions of ABMT. AB, ED‐related symptoms, depression, anxiety and stress were assessed before and after ABMT in the research groups, and, similarly, 5 weeks apart, in the controls. We found that despite the different patterns of change in AB between the three groups following ABMT, the reduction in AB, or the between‐group differences in AB‐reduction, were not significant. While the severity of ED‐symptoms, depression, anxiety and stress was reduced following ABMT, or control condition, in all groups, there were no between‐group differences in these changes. Changes in AB were not correlated with baseline and pre‐post‐treatment changes in ED‐related and comorbid symptomatology. Methodological and inpatient treatment‐related considerations may explain our negative ABMT‐related results.
Wind power policies in China: Development themes, evaluation, and recommendations
Authors: Zhou Haiwei , Zhang Jichang , Zhao Youlin 
Published: November 2022

AbstractThe scale of wind power generation in China is increasing, and China has become the largest producer of wind power in the world. This is mainly due to government policy support, providing investors with sufficient incentive to invest. With the saturation of the market, the development of the wind power industry has encountered a bottleneck. Strengthening the market facilities will be the focus of the development of the wind power industry in China in the future. We collected wind power policies in China in the past 20 years, used a latent Dirichlet allocation theme model to find themes in the process of wind power policy continuation, and then constructed the policy modeling consistency index model to quantitatively evaluate the effects of these policies. Finally, we discuss the changes needed for China's wind power policy in the future. We suggest that to achieve the market‐oriented construction goal of wind power in China, future policy needs to strengthen the importance of market allocation, optimize the business environment, and improve the efficiency of resource utilization.
The value of experiments in futures and foresight science as illustrated by the case of scenario planning
Authors: Derbyshire James , Dhami Mandeep , Belton Ian , Önkal Dilek 
Published: November 2022

AbstractAn already pressing need to evidence the effectiveness of futures and foresight tools has been further amplified by the coronavirus pandemic, which highlighted more mainstream tools' difficulty with uncertainty. In light of this, the recent discussion in this journal on providing futures and foresight science with a stronger scientific basis is welcome. In this discussion critical realism has been proffered as a useful philosophical foundation and experiments a useful method for improving this field's scientific basis. Yet, experiments seek to isolate specific causal effects through closure (i.e., by controlling for all extraneous factors) and this may cause it to jar with critical realism's emphasis on uncertainty and openness. We therefore extend the recent discussion on improving the scientific basis of futures and foresight science by doing three things. First, we elaborate on critical realism and why the experimental method may jar with it. Second, we explain why the distinction between a conceptual and a direct replication can help overcome this jarring, meaning experiments can still be a valuable research tool for a futures and foresight science underpinned by critical realism. Third, we consider the appropriate unit of analysis for experiments on futures and foresight tools. In so doing, we situate the recent discussion on improving the scientific basis of futures and foresight science within the much longer running one on improving the scientific basis of business, management and strategy research more broadly. We use the case of scenario planning to illustrate our argument in relation to futures and foresight science.
Repetitive DNA is Functional and Encodes Parts of the Non‐Coding RNA Repertoire
Authors: Shapiro James A. 
Published: November 2022

AbstractThis is a commentary on the article by Eviatar Nevo and Kexin Li entitled “Sympatric Speciation in Mole Rats and Wild Barley and Their Genome Repeatome Evolution: A Commentary”, published recently in Advanced Genetics.
Insights about personality traits and cognitive performance and decline in adults 51–59 Years old from the Wisconsin longitudinal study
Authors: Beaudreau Sherry A. , Gould Christine E. , Hantke Nathan C. , Kramer Abigail O. , Suresh Madhuvanthi , Jo Booil , Fairchild Jennifer K. 
Published: November 2022

AbstractObjectivesTo delineate midlife personality dimensions of early cognitive change in an age‐homogenous sample of U.S. older adults.DesignLongitudinal study of 6133 adults from the Wisconsin Longitudinal Study (WLS).MeasuresMiddle‐aged participants (mean age = 53.2; SD = 0.6) from the WLS completed the ‘Big‐5’ personality assessment in 1992. Mixed effects models examined whether midlife personality traits were associated with change in cognitive performance from participant's mid‐60s (2004–2005) to early 70s (2011). The cognitive battery assessed abstract reasoning (AR), category fluency (CF), working memory (WM), and delayed verbal memory (DVM). Models adjusted for sex, education, and subjective health.ResultsHigh Openness was a significant predictor of change in AR, CF, and DVM. These cognitive outcomes declined less among those with high Openness, but the effect sizes for Openness by time were small (R2s < 0.01). AR and CF were characterized by higher overall performance with high Openness, but with relatively parallel change for the highest and lowest Openness quartiles. There was no advantage of Openness to DVM by the second assessment. High Conscientiousness was a predictor of more change for DVM, though the effect size was small (R
2 < 0.01).ConclusionsNone of the midlife personality traits were uniformly associated with change in cognitive performance in early older adulthood. High midlife Openness had the most noteworthy impact on cognition. Interventions designed to target Openness have potential to elevate and maintain a higher threshold of performance in some cognitive domains, but may only have a small impact on cognitive change.
Are neuropsychiatric symptoms a marker of small vessel disease progression in older adults? Evidence from the Lothian Birth Cohort 1936
Authors: Clancy Una , Radakovic Ratko , Doubal Fergus , Hernández Maria del C. Valdés , Maniega Susana Muñoz , Taylor Adele M. , Corley Janie , Chappell Francesca M. , Russ Tom C. , Cox Simon R. , Bastin Mark E. , Deary Ian J. , Wardlaw Joanna M. 
Published: November 2022

AbstractBackgroundNeuropsychiatric symptoms could form part of an early cerebral small vessel disease prodrome that is detectable before stroke or dementia onset. We aimed to identify whether apathy, depression, anxiety, and subjective memory complaints associate with longitudinal white matter hyperintensity (WMH) progression.MethodsCommunity‐dwelling older adults from the observational Lothian Birth Cohort 1936 attended three visits at mean ages 73, 76, and 79 years, repeating MRI, Mini‐Mental State Examination, neuropsychiatric (Dimensional Apathy Scale, Hospital Anxiety and Depression Scale), and subjective memory symptoms. We ran regression and mixed‐effects models for symptoms and normalised WMH volumes (cube root of WMH:ICV × 10).ResultsAt age 73, 76, and 79, m = 672, n = 476, and n = 382 participants attended MRI respectively. Worse apathy at age 79 was associated with WMH volume increase (β = 0.27, p = 0.04) in the preceding 6 years. A 1SD increase in apathy score at age 79 associated with a 0.17 increase in WMH (β = 0.17 normalised WMH percent ICV, p = 0.009). In apathy subscales, executive (β = 0.13, p = 0.05) and emotional (β = 0.13, p = 0.04) scores associated with increasing WMH more than initiation scores (β = 0.11, p = 0.08). Increasing WMH also associated with age (β = 0.40, p = 0.002) but not higher depression (β = ‐0.01, p = 0.78), anxiety (β = 0.05, p = 0.13) scores, or subjective memory complaints (β = 1.12, p = 0.75).ConclusionsApathy independently associates with preceding longitudinal WMH progression, while depression, anxiety, and subjective memory complaints do not. Patients with apathy should be considered for enrolment to small vessel disease trials.
The bi‐directional association between loneliness and depression among older adults from before to during the COVID‐19 pandemic
Authors: Ward Mark , Briggs Robert , McGarrigle Christine A. , De Looze Celine , O’Halloran Aisling M. , Kenny Rose Anne 
Published: November 2022

AbstractBackgroundOlder adults have both the highest risk of contracting SARS‐CoV‐2 and in many jurisdictions have had additional restrictions placed on the social interactions. As a result, the COVID‐19 pandemic has led to increased depression and loneliness among older adults. Using data from an established cohort of older adults, the aims of this study was to describe changes in loneliness and depression and to examine the directionality of the association between depression and loneliness over a 5‐year period that included the early months of the pandemic.MethodsData were from The Irish Longitudinal Study on Ageing (TILDA), a large cohort of community‐dwelling adults aged 54+. We applied an auto‐regressive cross‐lagged panel modelling approach to estimate the effect of depression on loneliness and vice versa over three time points.ResultsBoth depression and loneliness increased significantly in the early months of the pandemic. While the association between loneliness and depression was bi‐directional, loneliness was a stronger predictor of depression.ConclusionThe strength and bi‐directionality of the association between loneliness and depression suggests that interventions to alleviate loneliness may also help reduce depressive symptoms and vice versa.
What are the factors associated with people with advanced dementia refusing assistance with personal care?
Authors: Backhouse Tamara , Killett Anne , Mioshi Eneida , Khondoker Mizanur 
Published: November 2022

AbstractBackgroundPeople with dementia sometimes refuse assistance with personal care activities such as washing or dressing. We aimed to investigate the factors associated with refusals of care in advanced dementia.MethodsA cross‐sectional study using informant‐based measures. Participants were people with advanced dementia and their caregivers (family carers or care‐home staff) (n = 260, 130 dyads) in the UK. Mixed effects linear models were used to examine the effects of neuropsychiatric behaviours, ability with activities of daily living, professional input, co‐morbidities, psychotropic medications, environment modifications, and caregiver factors including type and training status on refusals of care. The Refusal of Care Informant Scale was used, range 1–13; higher scores indicate more refusal behaviours.ResultsHigher independence in activities of daily living was associated with less refusal behaviours (coefficient = −0.11, p < 0.001 [95% confidence interval −0.15, −0.07]). Higher agitation was associated with more refusal behaviours (0.11, p < 0.001 [0.06, 0.15]). No other statistically significant differences were found. There was no demonstrable evidence of differences in number of refusals of care between family and care‐home caregivers or between dementia‐trained or ‐untrained caregivers.ConclusionsResults suggest refusals of care have similar prevalence regardless of caregiver type (family or care home) or dementia training status, indicating that current dementia training has no impact on refusals of care or may not be implemented as intended. Improving independence in activities of daily living and reducing agitations may help prevent refusals of care. To establish causality, future research should consider embedding these factors into interventions targeting refusal of care.