bluuebunny/crossref_metadata_2025_split huggingface dataset:
145 Evaluating the Impact of Time Between Radical Prostatectomy (RP) and Adjuvant Radiation Therapy (RT) on Erectile Function Recovery (EFR)
Authors: Martinez J. Flores , Benfante N. , Schofield E. , Mulhall J.P. 
Published: May 2022

ABSTRACT

Introduction
RT post-RP in men with PSA recurrence improves survival. It is also associated with a higher rate of urinary incontinence and erectile dysfunction (ED).

Objective
We attempted to evaluate if the time period between RP and adjuvant RT predicts EFR outcomes.

Methods
Men who received RT post-RP with ≥2 years post-RT follow-up were analyzed. ADT and RT pre-RP were exclusions. Demographics, comorbidities and pathological parameters and IIEF erectile function domain (EFD) scores were recorded. We report median EFD scores and factors correlated with EFR ≥24 months post-RT. Factors included: patient age, comorbidities, smoking status, baseline pre-RP and pre-RT Testosterone (T), prostate specific antigen (PSA), baseline EFD score, Nerve-Vascular bundle (NVB) status, and time between RP and RT.

Results
126 men were included. Mean age at RP was 63 ± 7 years. Mean pre-RP T was 390 ± 222 ng/dL, PSA, 10.2 ± 10.4 ng/mL and median EFD score were 27 (IQR = 20-30). Median pre-RT T was 376.9 ± 187 ng/dL, PSA 0.25 ± 0.33 ng/mL, and median EFD score was 9 (IQR = 3-20). 54% of patients had bilateral NVB preservation, and 29.5% unilateral. 71% received ADT with their RT, the median duration of ADT exposure was 4.5 (IQR = 3-8.5) months. Median time between RP and RT was 14.9 months (IQR = 8.5-28.6) months; 41% had ≤1 year between RP and RT. 2 years post RT, median EFD was 9.5 (IQR = 3-22). 22% had a score ≥24. EFD score at follow-up was correlated with age at RP (r=-0.32, p&lt;.001), and pre-RT EFD score (r=0.56, p&lt;.001). Time between RP and RT did not correlate with EFD score at follow up (r=0.08, p=0.39).

Conclusions
In our prostate cancer patients cohort post-RP/RT, EFR is lower; almost 4 of 5 patients will have some ED degree at two years post-RT. The period time between RP and RT is not correlated with EFR post-RT.

Disclosure
Work supported by industry: no.
153 Surveillance of Sexual Function After Robot-Assisted Laparoscopic Radical Prostatectomy
Authors: Shimizu S. , Jo T. , Kakumae S. , Nakatsuka T. , Morinaka H. , Hirata K. , Takasaki H. , Sugiyama S. , Ohira S. , Kaifu M. , Fujii T. , Miyaji Y. , Nagai A. 
Published: May 2022

ABSTRACT

Introduction and Objectives
Sexual dysfunction is one of the main factors that affects for quality of life (QOL) after prostatectomy. Previous research showed that sexual dysfunction after laparoscopic radical prostatectomy (LRP) was caused at 1 month, and refractory sexual dysfunction persisted for a long time. In recent years, robot-assisted laparoscopic radical prostatectomy (RALP) has been introduced at a large number of medical facilities. This time, we investigated change of sexual function after RALP using questionnaires related to sexual function.

Materials and Methods
Thirty-two patients were diagnosed localized prostate cancer and underwent RALP between January 2020 and June 2021 at our hospital. We investigated the change of sexual and voiding functions using International Index of Erectile Function (IIEF5), Expanded Prostate Cancer Index Composite (EPIC) at the time of diagnosis, 1, 3, 6, 12 month after RALP, and daily use numbers of urinary pad at 1, 3, 6, 12 month after RALP. Control was set at the time of diagnosis. This study was approved by the Ethics Committee of our facility (Approval No.3906-00).

Results
Patient age (median) was 67.5 (range 50-80) years old, body mass index (median) was 22.5 (range 17.4-28.7) kg/m2, and serum PSA (median) was 7.5 (range 4.0- 31.9) ng/ml at the time of diagnosis. Clinical stage T1c was accounted for 7 cases, T2a was 9 cases, T2b was 3 cases, T2c was 11 cases, and T3a was 2 cases. Fourteen patients (43.8%) underwent nerve-sparing RALP. IIEF5 and sexual function domain of EPIC showed deterioration at 1 month after RALP. However, sexual bother domain of EPIC showed not significant difference after RALP. The relevance between change of sexual function and nerve-sparing operation were not observed at our observation period. On the other hand, daily use numbers of urinary pad were significantly improved as time passed compared with that of at 1 month after RALP. The relevance between urinary continence and nerve-sparing operation were observed at 1 month after RALP.

Conclusions
Sexual dysfunction after RALP showed the same change as that after LRP. Besides, nerve-sparing operation might affect for urinary continence instead of sexual function.

Disclosure
Work supported by industry: no.
160 Treatment and Comorbidities of Patients with Erectile Dysfunction Before and During COVID-19 in the United States: A Real-World Data Analysis
Authors: Goldstein I. , Hassan T. , Li J. , Riad M. , Vignesh S. , Zou K. 
Published: May 2022

ABSTRACT

Introduction
Erectile dysfunction (ED) is usually a symptom of another medical condition. People with poor overall health are more likely to develop severe form of coronavirus disease 2019 (COVID-19) and may have unwanted symptoms such as ED. COVID-19-related stress, anxiety, and depression can also impact sexual health and possibly lead to ED. There are various treatment options for patients with ED. However, real-world evidence of the impact of COVID-19 on the treatment and comorbidities of patients with ED is limited.

Objectives
To estimate the impact of COVID-19 on the treatment and comorbidities of patients with ED in the United States.

Methods
This retrospective real-world data (RWD) analysis used the IQVIA PharMetrics® Plus claims database, which is a patient-Centric, closed claims database of fully adjudicated pharmacy, hospital and medical claims anonymized at the patient level, that captures the complete patient journey for all services billed to and covered by the patient's health plan. We compared the ED treatment and comorbidities in adult males aged 18+ years with ED in the same 3-month periods before (01March - 31May, 2019) and during (01March – 31May, 2020) the COVID-19 pandemic. ED treatment included any ED-related claims, prescriptions of any and individual phosphodiesterase-5 inhibitor (PDE5i) medications (avanafil, sildenafil, tadalafil and vardenafil).

Results
See the table below for number of patients having ED-related claims, having any and individual PDE5i prescriptions, number of patients with COVID-19 diagnosis, and percentage of patients with each of the top 10 comorbidities, in the 3-month periods before and during COVID-19.

Conclusions
RWD showed that ED-related claims significantly decreased during the COVID-19 pandemic, reflecting the pandemic's impact on ED patients’ health. However, the use of PDE5i medications remained stable during the pandemic. Key comorbidities including hypertension, hyperlipidemia, type 2 diabetes mellitus, benign prostatic hyperplasia with lower urinary tract symptoms, testicular hypofunction, and malignant neoplasm of the prostate, during the pandemic, compared with pre-pandemic period, highlighted the impact of the pandemic on ED patients’ health and need for managing their other comorbid chronic diseases.

Disclosure
Work supported by industry: yes, by Viatris. A consultant, employee (part time or full time) or shareholder is among the authors (Viatris).
162 Assessment of the Results of Treatment Erectile Dysfunction in Diabetic Patients by Tadalafil 20mg Once Every There Days
Authors: Nguyen Q. , Van H. Do 
Published: May 2022

ABSTRACT

Introduction
Tadalafil (a PDE5 inhibitor) is used to treat erectile dysfunction (ED), which can be dosed on-demand or daily. Tadalafil has a long half-life, so it has a long-lasting effect. Men with ED also have a preference for a treatment that is time-independent

Aim
To evaluate the efficacy and safety of tadalafil 20 mg with a dose of one tablet every three days in the treatment of erectile dysfunction among diabetic patients.

Material and methods
A prospective study was carried out on 22 men with diabetes who were examined with symptoms of erectile dysfunction satisfying the selection criteria at Center for Andrology and Sexual Medicine - VietDuc University Hospital from June 2020 to June 2021. These patients were treated with tadalafil 20 mg once every three days.

Results
There were 22 patients included in the study, mean age was 52.1 years old. The baseline degree of erectile dysfunction was mainly mild to moderate (accounting for 73%). The average IIEF-5 score before and after treatment was 12.2 and 19.3, respectively. The improvement of IIEF-5 score was statistically significant (p &lt;0.05). Headache was the most common side effect, accounting for 13.6%, followed by facial flushing, nasal congestion, myalgia and back pain with 9.1%, palpitations and digestive disorders with 4.5%.

Conclusion
tadalafil 20mg dosed one tablet every three days for the treatment of erectile dysfunction among diabetic patients has a statistically significant effect; hopefully, providing an additional option for the safe treatment of erectile dysfunction in diabetic patients.

Disclosure
Work supported by industry: no.
163 PDE5 Inhibitor Prescribing in Hypertension
Authors: Mita K. 
Published: May 2022

ABSTRACT

Purpose
We will analyze the PDE5 inhibitor prescription at Kobe-Sannomiya EAST Ekimae Clinic(predecessor).

Methods
To analyze the type of antihypertensive drug in hypertensive patients receiving pharmacotherapy among male re-examination patients who prescribed PDE5 inhibitors more than 6 months after the initial consultation.

Results
The target 445 age groups were 5 in their 30s, 35 in their 40s, 144 in their 50s, 177 in their 60s, 79 in their 70s, and 5 in their 80s. The elapsed time from initial consultation to re-examination was 96 for 6 months or more and less than 1 year, 214 for 1 year or more and less than 2 years, and 135 for 2 years or more. The antihypertensive drugs were Ca antagonist 133 (24 other drugs other than ARB), angiotensin Ⅱ receptor antagonist (ARB) 112 (19 other drugs other than Ca antagonist), Ca antagonist and there were 186 patients with ARB (43 with other drugs) and 14 with other drugs. The breakdown of other concomitant drugs and other drugs was β-blockers, α-blockers, αβ-blockers, ACE inhibitors, and diuretics. Very few patients voluntarily complained of ED symptoms associated with taking antihypertensive drugs, and various types of antihypertensive drugs were taken.

Discussion
Even if a PDE5 inhibitor is more effective, it is necessary to consult with your GP about taking antihypertensive drugs.

Disclosure
Work supported by industry: no.
189 Ethnic Underrepresentation in Validation of Female Sexual Dysfunction Questionnaires
Authors: Redmon C. , Alzweri L. 
Published: May 2022

ABSTRACT

Introduction
Female sexual dysfunction (FSD) is a significant cause of morbidity that affects an estimated 30-50% of women. FSD is characterized by conditions which cause distress in at least one area – desire, arousal, orgasm, or pain – and can be challenging to diagnose depending on the patient-provider relationship and/or individual levels of comfort in having such discussions. Several questionnaires have been developed over the past four decades to assess FSD. This repertoire of tools includes assessments of overall sexual function, quality of life, and specific dysfunctions (i.e., hypoactive sexual desire disorder).

Objective
The purpose of this review is to evaluate the ethnic representation of sample populations used in the studies to validate these questionnaires.

Methods
A literature search was performed to gather information on questionnaires that have been developed to assess FSD. Subsequent searches were targeted to obtain the published studies used to validate each tool. Collective averages from the combined ethnic data were compared to population data from US census data and healthcare workforce reports to evaluate epidemiologic diversity. Ethnicity data from each questionnaire were investigated longitudinally to evaluate trends in representation of these sample populations over the past 40 years.

Results
Nineteen questionnaires were evaluated for ethnic representation based on published validation studies. Each questionnaire was tabulated to include the domain(s) assessed, number of items in each questionnaire, validation sample population size and description, and available ethnicity breakdown for each questionnaire. The average ethnic representation of the questionnaires relative to the US general population and US female health care workforce, respectively, was: Caucasian (78.3% vs. 62.7% and 68.5%), African American (3.3% vs. 13.3% and 8.3%), Hispanic (2.3% vs. 16.0% and 9.6%), American Indian (0.0% vs. 0.8% and 0.3%), Asian (0.6% vs. 6.4% and 6.2%), and Other (0.7% vs. 0.7% and 1.4%).

Conclusions
FSD is a common condition affecting women and causes significant impacts on quality of life. Review of the sample populations used to validate the questionnaires used to evaluate FSD in routine practice shows underrepresentation of ethnic minorities when compared to general population demographics. FSD questionnaire is an important research tool, helps increase health care providers and patients awareness of FSD, in addition, eventually improving access to care for ethnic minority women.

Disclosure
Work supported by industry: no.
193 Sexual Attitudes of Turkish Population During the COVID-19 Outbreak
Authors: Sahin O. , Culha M.G. , Demir O. , Avsar M.T. 
Published: May 2022

ABSTRACT

Introduction
During the worldwide COVID-19 pandemic, the psychological and mental conditions of the society worsen. The aim of this study is to examine the changes in their sex lives due to the Turkish COVID-19 outbreak.

Method
This online survey was conducted between April and June 2020 with 468 patients admitted to the hospital. After the approval was given, an online questionnaire was sent from the hospital database and from the social media accounts of health institutions (Twitter, Facebook, Instagram, WhatsApp, etc.) and e-mail addresses. The first part of the four-part questionnaire included demographic data, the second and third parts of attitudes before and after COVID-19, and the last part to assess sexual functions, sleep, anxiety and depression.

Results
The study was completed with a total of 390 participants. The response rate of the study is 83.33%. Sexual desires of healthcare workers (3.78 ± 1.03 vs. 3.07 ± 1.11; p &lt;0.001), weekly sexual intercourse / masturbation number (2.58 ± 1.01 vs. 1.18 ± 1.01; p &lt;0.001), duration of foreplay (19.27 ± 11.28 vs.10.12 ± 11.04; p &lt;0.001), duration of sexual intercourse (24.65 ± 15.67 vs. 14.25 ± 15, 63; p &lt;0.001) decreased compared to before the COVID-19 outbreak. In addition, participants preferred less foreplay (p &lt;0.001), less oral sex (p &lt;0.001) and anal sex (p: 0.007), and more non-face-to-face positions during COVID-19 (p &lt;0.001) . When the factors affecting sexual dysfunction were examined as univariate and multivariate, it was shown that sexual dysfunction was significantly more common in male gender (OR: 2.048) and alcohol users (OR: 3.836). The shortcoming of the study is that the pre-COVID-19 sexual and mental states of the participants were not assessed with the validated questionnaire.

Conclusion
During the COVID-19 pandemic, the public's sexual desire decreased, the number of sexual intercourse decreased, the duration of foreplay was reduced, and the preference to be face-to-face in sexual intercourse positions decreased.

Disclosure
Work supported by industry: no.
201 Survey on Sexuality in Manhood in Japan Using an Internet Questionnaire
Authors: Tobu S. , Noguchi M. 
Published: May 2022

ABSTRACT

Objective
Research on erectile dysfunction and the development of medications for erectile dysfunction has been actively carried out both in Japan and overseas. However, studies on the sexuality of Japanese men. such as the actual situation concerning intravaginal ejaculation disorder, masturbation, and the foreskin status. have been insufficient. One reason for this is because obtaining responses to questionnaires about such matters is difficult, as these are sensitive subjects. We therefore conducted a survey on sexuality in manhood in Japan using an internet questionnaire and report the findings.

Methods
Using Macromill's internet survey tool, 110 men each 20-29 (20s), 30-39 (30s), 40-49 (40s) and 50-59 (50s) years old (440 in total) were asked whether or not they had any intravaginal ejaculatory disorders, whether or not they masturbated and in what position if they did so (lying on their backs while stretching their legs or lying face-down [called prone masturbation]), the status of their foreskin (incomplete or complete phimosis) and whether or not they had ever been reluctant to associate with a partner.

Results
8.1% of respondents in their 20s, 6.8% in their 30s, 7.0% in their 40s and 8.4% in their 50s answered that they had experienced intravaginal ejaculation disorders more than once every two instances of intercourse. Regarding the position adopted for masturbation, as prone masturbation can cause intravaginal ejaculation disorder, the frequency lying on the back was 29.1% in respondents in their 20s, 30.0% in those in their 30s, 27.3% in those in their 40s and 25.5% in those in their 50s, and the frequency of prone masturbation was 6.3% in respondents in their 20s, 6.3% in those in their 30s, 0.9% in those in their 40s and 4.5% in those in their 50s. Adopting the position of lying on one's back was more prevalent than prone masturbation for each generation. However, regarding the degree of awareness of intravaginal ejaculation disorder, those who masturbated while lying on their backs accounted for 18.7% in those in their 20s, 29.4% in those in their 30s, 29.1% in those in their 40s and 40.9% in those in their 50s, while those who masturbated in the prone position accounted for 42.8% in those in their 20s, 57.1% in those in their 30s, 100% in those in their 40s and 80.0% in those in their 50s. These findings indicate that prone masturbation was significantly more associated with intravaginal ejaculation disorder than lying on one's back while stretching the legs. Regarding the foreskin status, 19.1% of respondents in their 20s, 29.1% in their 30s, 36.7% in their 40s and 40.9% in their 50s answered that the foreskin was always peeled back.

Conclusion
Despite the difficulty guaranteeing the accuracy of data obtained through questionnaire surveys using the internet compared to individually administered questionnaires, this approach seems to be very useful for surveys involving sensitive content, as in this study.

Disclosure
Work supported by industry: no.
204 Awareness Survey on Adverse Events Including Sexual Dysfunction Associated with Cancer Treatment
Authors: Ikuta H. , Fujimoto N. 
Published: May 2022

ABSTRACT

Introduction
In clinical practice, we often experience differences in perceptions between patients and healthcare professionals about adverse events in cancer treatment. Some patients consider that there are adverse events that they want to avoid, even if the treatment is slightly less effective.

Objective
In order to refer to the explanation about adverse events in cancer treatment, we conducted an awareness survey on adverse events including sexual dysfunction in cancer treatment of patients.

Methods
An anonymous questionnaire survey was conducted for those who cooperated with the outpatients department of urology at our hospital and those who visited related hospitals. In the questionnaire, we decided to select the adverse events those the patient would like to avoid even if the therapeutic effect is slightly inferior in the treatment of cancer. In the questionnaire, (1)respiratory symptoms, (2)dietary symptoms, (3)symptoms related to defecation, (4)skin symptoms, (5)numbness, weakness, joint pain, (6)fatigue, decreased vitality, (7) hot flashes, (8)fever, infectious disease, (9)hair loss, (10)anxiety, depression, (11)infertility, and (12)sexual dysfunction, are listed as items of adverse events. Multiple answers were allowed for them. Regarding sexual dysfunction, we also confirmed whether or not there was a desire to see a specialist when symptoms appeared.

Results
As of July 1, 2021, the questionnaire was collected in 90 cases (74 males and 16 females). The median items selected by each respondent were 3 items (range 0-12). 73 (81.1%) respondents selected one or more items. The number of people who chose sexual dysfunction was 10 (11.1%), all of whom were male (20-39years old: 0 people, 40-59years old: 1 person, 60-69years old: 4 people, 70-79years old: 3 people, 80years old and over: 2 people). In addition, 5 (5.6%) wanted to see a specialist when sexual dysfunction appeared. Regarding other items, respiratory symptoms, dietary symptoms, defecation-related symptoms, fever and infectious diseases, were all selected by more than 45% of the respondents.

Conclusions
More than 80% thought that there were complications to avoid when treating cancer, even if the treatment was a little inferior. Among them, adverse events that directly interfere with daily life tended to be avoided more. In daily clinical practice, the frequency of patients who consider changing treatment due to sexual dysfunction in cancer treatment is low. However, in this survey, it was confirmed that a certain number emphasizes sexual dysfunction.

Disclosure
Work supported by industry: no.
210 The Effect of Antioxidant Supplementation on Operated or Non-Operated Varicocele-Associated Infertility: A Systematic Review and Meta-Analysis
Authors: Pyrgidis N. , Sokolakis I. , Palapelas V. , Tishukov M. , Mykoniatis I. , Symeonidis E.N. , Zachariou A. , Kaltsas A. , Sofikitis N. , Hatzichristodoulou G. , Dimitriadis F. 
Published: May 2022

ABSTRACT

Introduction
In patients with varicocele-associated infertility, the effect of antioxidant supplementation on fertility is unknown.

Objectives
To perform a systematic review and meta-analysis exploring the role of antioxidant supplementation in patients with operated or non-operated varicocele.

Methods
We searched PubMed, Cochrane Library, Web of Science and Scopus databases, as well as sources of grey literature until May 2021 (PROSPERO: CRD42021248195). We produced a qualitative synthesis of the main results extracted from the included studies. Based on data availability, we undertook an inverse variance, random effects meta-analysis of odds ratios (ORs) to determine the pregnancy rate after antioxidant supplementation versus no treatment in patients undergoing surgical repair of varicocele at three and six months of treatment. In these patients, we determined the effect of antioxidant supplementation versus no treatment or placebo on semen parameters (concentration, motility, morphology, and DNA fragmentation).

Results
We included 14 studies (980 individuals) in the systematic review. Of the 14 studies, 2 explored the effect of antioxidant supplementation in patients with non-operated varicocele, 1 compared antioxidants versus surgical repair of varicocele, while 11 explored antioxidants after surgical repair of varicocele and were also included in the meta-analysis. Regarding pregnancy rates, no significant differences were demonstrated after treatment with antioxidants versus no treatment at three (OR: 2.28, 95% CI: 0.7–7.48) and six months (OR: 1.88, 95% CI: 0.62–5.72). Accordingly, contradictory findings were reported in sperm concentration, morphology, and motility, as well as DNA fragmentation.

Conclusions
Our findings indicate that antioxidant supplementation does not improve pregnancy rates and semen parameters in patients with varicocele-associated infertility, in the absence of previous screening for oxidative stress. Based on the previous notion, most included studies also raised methodological concerns. Therefore, definitive conclusions about the efficacy of antioxidant supplementation in this setting cannot be drawn and further research on the field is mandatory.

Disclosure
Work supported by industry: no.