bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uncovering the ligandome of low-density lipoprotein receptor-related protein 1 in cartilage: a top-down approach to identify therapeutic targets
Authors: Yamamoto Kazuhiro , Scavenius Carsten , Meschis Maria M , Mogensen Emilie H , Gremida Abdulrahman M E , Thøgersen Ida B , Bonelli Simone , Scilabra Simone D , Santamaria Salvatore , Ahnström Josefin , Bou-Gharios George , Enghild Jan J , Nagase Hideaki 
Published: March 2022

AbstractThe low-density lipoprotein receptor-related protein 1 (LRP1) is a cell-surface receptor ubiquitously expressed in adult tissues. It plays tissue-specific physiological roles by mediating endocytosis of a diverse range of extracellular molecules. Dysregulation of LRP1 is involved in multiple conditions including Alzheimer’s disease, atherosclerosis and osteoarthritis (OA). However, little information is available about the specific ligand profile (ligandome) for each tissue, which would lead to better understanding of its role in disease states. Here, we investigated adult articular cartilage where impaired LRP1-mediated endocytosis leads to tissue destruction. We used a top-down approach involving analysis of human chondrocyte secretome, direct binding assays and validation in LRP1-deficient fibroblasts, as well as a novel Lrp1 conditional knockout (KO) mouse model. We found that inhibition of LRP1-mediated endocytosis results in cell death, alteration of the entire secretome and transcriptional modulations in human chondrocytes. We have identified more than 50 novel ligand candidates and confirmed direct LRP1 binding of HGFAC, HMGB1, HMGB2, CEMIP, SLIT2, ADAMTS1, IGFBP7, SPARC and LIF. Our in vitro endocytosis assay revealed the correlation of their affinity for LRP1 and the rate of endocytosis. Moreover, a conditional LRP1 KO mouse model demonstrated a critical role of LRP1 in regulating the high-affinity ligands in cartilage in vivo. This systematic approach revealed the extent of the chondrocyte LRP1 ligandome and identified potential novel therapeutic targets for OA.
The effectiveness of Tamarindus Indica extracts as a metal corrosion inhibitor in various circumstances
Authors: Nasser Rabab M. , Masmali Nora M. 
Published: March 2022

Purpose
Plant development and use as green corrosion inhibitors are already recognized as one of the most environmentally friendly and effective protocols. In recent years, efforts have been made to find green corrosion inhibitors as an alternative to synthetic inhibitors for metals in acid medium. This paper aims to report the investigation of use of aqueous extracts of Tamarindus Indica as green inhibitors for corrosion of metals within different circumstances.

Design/methodology/approach
The use of Tamarindus Indica extracts (leaves, stem, fruit pulp and fruit husk) as corrosion inhibitors for mild steel and aluminum in different mediums (HCl, H2SO4, formic acid and citric acid) at different temperatures was investigated.

Findings
The inhibitory efficiency of Tamarindus Indica extracts increases with increasing concentration and decreases with increasing temperature. Langmuir is the adsorption isotherm, and the extract (inhibitor) is a mixed-type inhibitor (physisorption and chemisorption).

Practical implications
Tamarindus extracts (leaves, stem, fruit pulp and fruit husk) are effective inhibitors and can be used to protect metals from corrosion at different circumstances.

Originality/value
To the best of the authors’ knowledge, this is the first review that discusses the use of Tamarindus Indica extracts as corrosion inhibitors for metals.
Intellectual capital, sustainable economic and financial performance and value creation in emerging markets: the case of Brazil
Authors: Jordão Ricardo Vinícius Dias , Almeida Vander Ribeiro de , Novas Jorge 
Published: March 2022

Purpose
The purpose of this paper is to analyze the influence of intellectual capital (IC) on sustainable economic and financial performance (EFP) and value creation (VC) in Brazilian companies.

Design/methodology/approach
Based on finance and accounting theories, a quantitative and descriptive long-term study was carried out in the companies listed on the Brazil Stock Exchange and Over-the-Counter Market (B3), covering 20 years period.

Findings
The results indicate that IC positively influences profitability, corporate return and organizational value sustainably; the most intangible-intensive Brazilian companies listed on B3 presented more robust results than the least intangible-intensive; and IC contributes to a systematic increase in EFP and VC over time.

Research limitations/implications
Using a well-established metric, the IC-INDEX, the IC and its effects were measured, obtaining theoretical contributions (expanding the understanding of the IC influence in sustainable EFP and VC from a long-term perspective – one subject still unexplored in the literature); and empirical (increasing the understanding of the IC’s role as a driver of competitiveness, performance and organizational value).

Practical implications
This study increases the understanding of the theoretical and practical effects of IC, also providing a competitive benchmarking process to access sustainable EFP and VC of companies and their industries.

Originality/value
The originally applied and validated proposal extends existing theory by offering a set of indicators to scale the contribution of IC to competitiveness from the perspective of long-term (historical) corporate outcomes.
Analysis of contractors' administrative characteristics in bid decision factors
Authors: Olatunji Oluwole Alfred , Ramanayaka Chamil Dilhan Erik , Rotimi Funmilayo Ebun , Rotimi James Olabode Bamidele 
Published: March 2022

PurposeThe normative literature suggests that there are more than seventy decision factors that contractors must consider if they intend to success in their bid and projects. In addition, such factors have been grouped in relation to project characteristics, client attributes, contractors' business administration and external factors. The extant literature suggests that the relationships between many of the bid decision factors are orthogonal and may not explain how bid-decisions shape project outcomes.Design/methodology/approachThis knowledge gap has stagnated research in this area. Building on findings of recent studies, this study unbundles bid decision themes by analysing key factors amongst contractors' administrative characteristics. In addition, the study determines intrinsic predictive correlation between the sub-themes. A total of 17 variables were listed in a structured questionnaire survey and presented to participants recruited through purposive snowballing. In total, 50 responses were received and formed the basis of descriptive and inferential statistical analyses.FindingsThe study found that the 17 factors are significant in bid decisions and consequently in bid successes. However, the explanatory variables attached to the themes are most efficient if categorised into six sub-themes. These are contractor's administration depth, strategic direction, commercial intention and own market advantage, resources, experience as well as openness to technology imposed by new projects. Furthermore, four theoretical positions are significant. Contractors bid for projects strategically; they are less reliant on their resource capabilities in bid decisions; every bid decision aligns with a risk strategy, and financial stability enables them to establish appropriate risk mitigation arrangements that could ensure project success.Originality/valueThese findings provide some support for the conceptual premise that bid decisions need to be rational, considered and strategically contribute to project outcomes.
Ambivalence toward bureaucracy: responses from Korean school principals
Authors: Joo Hyun-Jun , Kim Taeyeon 
Published: March 2022

PurposeGiven the context of accountability-driven policy environments, research has shown that school leaders perceive bureaucratic rules and protocols in negative ways, but they also utilize organizational structures and routines to lead changes. To better understand both enabling and hindering mechanisms of bureaucracy in schools, this study explores how Korean school principals understand and perceive bureaucratic structures using a lens of ambivalence. The authors draw on Weber's theory of bureaucracy, with a particular focus on the paradoxical aspect of bureaucracy that might be experienced by individuals within the system.Design/methodology/approachThis study analyzed qualitative data collected from 26 in-depth interviews with 10 Korean school principals between 2013 and 2015. The authors used the multiple cycles of coding to explore patterns and themes that emerged from the participants' responses.FindingsThe analysis of this study showed that the participants' ambivalent responses toward bureaucracy were particularly salient in three areas where formal organizational structures were changing through policy initiatives: teacher evaluation, electronic approval system and school-based management promoting decentralized decision making. The study participants reflected on how such changes can enable and/or hinder schools to achieve organizational goals and collective values, from the viewpoints of multiple aspects, which led to their ambivalent responses to bureacratic structures in school settings.Originality/valueThis study contributes to the understanding of school organizations by revisiting Weber's theory of bureaucracy in school settings. Using the lens of ambivalence enabled us to reconcile school principals' contradictory perceptions toward bureaucracy, which complicates analyses of tensions and paradoxical responses found in leadership practices within school systems.
A novel utilization-aware and power-delay-aware intelligent DMA controller for video streaming used in AI applications
Authors: Kumar B. Santosh , E. Krishna Kumar 
Published: March 2022

Purpose
In real-time entertainment processing applications, processing of the multiple data streams demands high efficient multiple transfers, which leads to the computational overhead for system-on-chip (SoC), which runs the artificial intelligence algorithms. High-performance direct memory access controller (DMAC) is incorporated in SoC to perform the multiple data transfers without the participation of main processors. But achieving the area-efficient and power-aware DMAC suitable for streaming the multiple data remains to be a daunting challenge among the researchers.

Design/methodology/approach
The purpose of this paper to provide the DMA operations without intervention of central processing unit (CPU) for bulk video data transmissions.

Findings
The proposed DMAC has been developed based on the hybrid advanced extensible interface (AXI)-PCI bus subsystem to handle the multiple data streams from the video sources. The proposed model consists of bus selector module, user control signal, status register, DMA-supported address and AXI-PCI subsystems to achieve better performance in analysing the video frames.

Originality/value
The extensive experimentation is carried out with Xilinx Zynq SoC architecture using Very High Speed integrated circuit hardware description language (VHDL) programming, and performance metrics such as utilization area and power are calculated and compared with the other existing DMA controllers such as Scatter-DMA, Gather-DMA and Enhanced DMA. Simulation results demonstrate that the proposed DMAC has outperformed other existing DMAC in terms of less area, less delay and power, which makes the proposed model suitable for streaming multiple video streams.
Creating a sense of community and space for subjectification in an online course on sustainability education during times of physical distancing
Authors: Hesen Robbert , Wals Arjen E.J. , Tauritz Rebekah L. 
Published: March 2022

Purpose
This study aims to demonstrate which course elements were responsible for community building, fostering subjectification and learning for being in an online course on environmental and sustainability education (ESE) during the COVID-19 pandemic and physical distancing.

Design/methodology/approach
The study investigates a graduate-level course on Environmental Education for Sustainable Living that due to COVID-19 had to be taught mainly online. A retrospective analysis was conducted when the facilitators reflected on why the course, against expectations, appeared to have affected so many students in such a meaningful and profound way as shown by their personal reflections and the course evaluation. Methodologically, this study can be described as explorative and interpretative, although it was complemented by a standardised empirical analytical end-of course evaluation.

Findings
Within the context of this study, sense of community is linked to and facilitated by the online learning environment and the educators’ and students’ roles throughout the course. This study found that interaction and inclusion can be augmented by a hybrid educational design and supported by the mutual efforts of educators and students. Reflective tasks and discussions most prominently evoked subjectification. The encouragement of students to see themselves as central subjects and the inclusion of creative tasks supported both personal exploration and sense of community.

Originality/value
This study provides educational institutions teaching online with valuable information regarding course elements that foster subjectification and create a sense of community. This is particularly of interest for the design of online ESE emphasising learning for being and more relational approaches towards teaching and learning.
Finding ways of searching for the disappeared: the information practices of the families in Colombia
Authors: Bermúdez Qvortrup Natalia 
Published: March 2022

PurposeThis study aims to explore and identify the information-seeking process and practices of those searching for the forcefully disappeared in Colombia. It answers the questions; how do families in Colombia seek information about a disappearance, how is this seeking process mediated and how are information barriers dealt with?Design/methodology/approachBased on document analysis and interviews with families and NGO representatives, this bottom-up study explores the trajectory of the families' information-seeking process to highlight the most salient information practices.FindingsA general trajectory of a search for information is laid out. The overwhelming barriers to information forces families to carry the burden of becoming information providers. NGOs provide situated learning on how to document a disappearance and deal with the state. This knowledge is passed on to families creating communities of practices. The information produced here becomes the main source of knowledge about this crime.Originality/valueIt makes a new contribution to the field of information practices by introducing the context of enforced disappearances using the example of Colombia, identifying a significant information-seeking process.
Influence of bull and bear market phase on financial risk tolerance of urban individual investors in an emerging economy
Authors: Arora Neha , Mishra Brijesh K. 
Published: March 2022

PurposeThis study aims to analyze how risk tolerance is influenced by bull and bear market phases, age and professional work experience (PWE) of investors in emerging economies. The authors also analyze how different market phases (bull and bear) influence risk tolerance of investors in emerging economies for different age groups and with varying PWE.Design/methodology/approachThe study uses two quantitative methods, one-way ANOVA and hierarchical regression model (HLM) to analyze individual investors' financial risk tolerance (FRT) in India.FindingsThe authors find that age and PWE have positive relationship with FRT behavior. However, interactions of these variables with market phase variable indicate that risk tolerance has nonlinear increasing relationship with investor's age and PWE. The risk tolerance of older investors is consistently high in both bull and bear market conditions, while young investors display a nonlinear risk behavior in different market conditions.Practical implicationsThe study suggests that financial planners should include a longitudinal risk profiling of investors based on age groups, PWE and the current market phase to better understand investors' FRT and also to prefer more context-specific advice to investors in emerging economies, which, consequently, result in increasing the retail investors' interest in otherwise sparsely participated equity market.Originality/valueInteraction effect of bull and bear market phases on relationship between age and PWE and FRT has been scantly studied.
Distribution and evolution of thermal stress in laser powder bed fusion: conduction mode versus keyhole mode
Authors: Chen Changpeng , Xiao Zhongxu , Xue Gang , Liao Hailong , Zhu Haihong 
Published: March 2022

Purpose
High temperature gradient induces high residual stress, producing an important effect on the part manufacturing during laser powder bed fusion (LPBF). The purpose of this study is to investigate the effect of the molten pool mode on the thermal stress of Ti-6Al-4V alloy during different deposition processes.

Design/methodology/approach
A coupled thermal-mechanical finite element model was built. The developed model was validated by comparing the numerical results with the experimental data in the maximum molten pool temperature, the molten pool dimension and the residual stress described in the previous work.

Findings
For the single-track process, the keyhole mode caused an increase in both the maximum stress and the high-stress area compared with the conduction mode. For the multitrack process, a lower tensile stress around the scanning track and a higher compressive stress below the scanning track were found in the keyhole mode. For the multilayer process, the stress along the scanning direction at the middle of the part changed from tensile stress to compressive stress with the increase in the deposition layer number. As the powder layer number increased, the stress along the scanning direction near the top surface of the part decreased while the stress along the deposition direction obviously increased, indicating that the stress along the deposition direction became the dominant stress. The keyhole mode can reduce the residual stress near the top of the part, and the conduction mode was more likely to produce a low residual stress near the bottom of the part.

Originality/value
The results provide a systematic understanding of thermal stress during the LPBF process.
Characterization of a dszEABC operon providing fast growth on dibenzothiophene and construction of broad‐host‐range biodesulfurization catalysts
Authors: Martín‐Cabello Guadalupe , Terrón‐González Laura , Santero Eduardo 
Published: March 2022

SummaryA new operon for biodesulfurization (BDS) of dibenzothiophene and derivatives has been isolated from a metagenomic library made from oil‐contaminated soil, by selecting growth of E. coli on DBT as the sulfur source. This operon is similar to a dszEABC operon also isolated by metagenomic functional screening but exhibited substantial differences: (i) the new fosmid provides much faster growth on DBT; (ii) associated dszEABC genes can be expressed without the need of heterologous expression from the vector promoter; and (iii) monooxygenases encoded in the fosmid cannot oxidize indole to produce indigo. We show how expression of the new dszEABC operon is regulated by the sulfur source, being induced under sulfur‐limiting conditions. Its transcription is activated by DszR, a type IV activator οf σN‐dependent promoters. DszR is coded in a dszHR operon, whose transcription is in turn regulated by sulfur and presumably activated by the global regulator of sulfur metabolism CysB. Expression of dszH is essential for production of active DszR, although it is not involved in sulfur sensing or regulation. Two broad‐host‐range DBT biodesulfurization catalysts have been constructed and shown to provide DBT biodesulfurization capability to three Pseudomonas strains, displaying desirable characteristics for biocatalysts to be used in BDS processes.
Incestuous childhood sexual abuse between siblings resulting in pregnancy without sexual intercourse
Authors: Eroglu İbrahim , Yildiz Abdulkadir , Seviçin Sedat 
Published: March 2022

AbstractVictims of incest are usually women and children who are mostly girls. The abuse between siblings may remain hidden because of the family's fear of social stigma, though it may result in pregnancy. This article presents a case of incestuous childhood sexual abuse between siblings resulting in pregnancy without intercourse, an event rarely reported in the literature. An 11‐year‐old girl was brought to the hospital because of a stomachache and was detected pregnancy from examinations. Forensic medicine experts determined that the girl's hymen was still intact and non‐elastic in the genital examination. Gynecology and Obstetrics Department confirmed the pregnant compatibility with 14 weeks, 4 days; after ultrasonographic monitoring. She was abused by her 14‐year‐old brother by rubbing for 1 year and this resulted in pregnancy. During the psychiatric examination, her attitude was negative and symptoms of post‐traumatic stress disorder emerged. Medical abortion was applied after psychiatric and gynecological examinations. The girl's brother was confirmed as the biological father after the DNA paternity test was conducted on the fetus. Based on this case, this article aimed to examine the medical, social, and legal problems caused by incestuous childhood sexual abuse and contribute to the literature by emphasizing what forensic medicine and preventive medicine approaches should consider in such cases.
“We keep the nightmares in their cages”: Correctional culture, identity, and the warped badge of honor*
Authors: Higgins Ethan M. , Smith Justin , Swartz Kristin 
Published: March 2022

AbstractCorrectional scholarship has demonstrated concern over the dehumanizing implications of the carceral state for incarcerated people. This concern has been paralleled by an interest in understanding the work of prison staff and how correctional subculture may play an active role in prison dehumanization. By drawing from focus groups from all prisons in one state, we investigate how correctional staff construct and manage their identity through “us–them” ideologies. We find that staff leverage negative attitudes toward the incarcerated, and that these attitudes were underpinned by sensational cultural stories and epithets. Moreover, we find that staff use “othering” toward the incarcerated as a means to construct a warped badge of honor, which illustrates the burdens they bear from prison work and which frames themselves as heroes, guardians, and protectors. We conclude with a discussion of the implications of our findings, where we consider how dehumanization illustrates the mental coping work staff endure to carry out the symbolic violence and dehumanizing objectives of the carceral system.