bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mesenchymal stem cells-derived therapies for subarachnoid hemorrhage in preclinical rodent models: a meta-analysis
Authors: He Jialin , Liu Jianyang , Huang Yan , Lan Ziwei , Tang Xiangqi , Hu Zhiping 
Published: January 2022

Abstract
Background
Mesenchymal stem cells (MSCs) and MSCs-derived extracellular vesicles (EVs) have emerged as potential novel therapies for subarachnoid hemorrhage (SAH). However, their effects remain incompletely understood. We aim to comprehensively evaluate the effect of MSCs-derived therapies in rodent models of SAH.

Methods
We searched PubMed, EMBASE, and Web of Science up to September 2021 to identify studies that reported the effects of MSCs or MSCs-derived EVs in a rodent SAH model. Neurobehavioral score was extracted as the functional outcome, and brain water content was measured as the histopathological outcome. A random-effects model was used to calculate the standardized mean difference (SMD) and confidence interval (CI).

Results
Nine studies published from 2018 to 2021 met the inclusion criteria. Studies quality scores ranged from 5 to 10, with a mean value of 7.22. Our results revealed an overall positive effect of MSCs and MSCs-derived EVs on the neurobehavioral score with a SMD of − 2.21 (95% CI − 3.14, − 1.08; p < 0.0001). Meanwhile, we also found that MSCs and MSCs-derived EVs reduced brain water content by a SMD of − 2.09 (95% CI − 2.99, − 1.19; p < 0.00001). Significant heterogeneity among studies was observed, further stratified and sensitivity analyses did not identify the source of heterogeneity.

Conclusions
Our results suggested that MSCs-derived therapies prominently improved functional recovery and reduced brain edema in the rodent models of SAH. Notably, the limitations of small sample size should be considered when interpreting the results, and large animal studies and human trials are needed for further investigation.
Exercise training worsens cardiac performance in males but does not change ejection fraction and improves hypertrophy in females in a mouse model of metabolic syndrome
Authors: Tóth Melinda E. , Sárközy Márta , Szűcs Gergő , Dukay Brigitta , Hajdu Petra , Zvara Ágnes , Puskás László G. , Szebeni Gábor J. , Ruppert Zsófia , Csonka Csaba , Kovács Ferenc , Kriston András , Horváth Péter , Kővári Bence , Cserni Gábor , Csont Tamás , Sántha Miklós 
Published: January 2022

Abstract
Background
Metabolic syndrome (MetS) refers to a cluster of co-existing cardio-metabolic risk factors, including visceral obesity, dyslipidemia, hyperglycemia with insulin resistance, and hypertension. As there is a close link between MetS and cardiovascular diseases, we aimed to investigate the sex-based differences in MetS-associated heart failure (HF) and cardiovascular response to regular exercise training (ET).

Methods
High-fat diet-fed male and female APOB-100 transgenic (HFD/APOB-100, 3 months) mice were used as MetS models, and age- and sex-matched C57BL/6 wild-type mice on standard diet served as healthy controls (SD/WT). Both the SD/WT and HFD/APOB-100 mice were divided into sedentary and ET groups, the latter running on a treadmill (0.9 km/h) for 45 min 5 times per week for 7 months. At month 9, transthoracic echocardiography was performed to monitor cardiac function and morphology. At the termination of the experiment at month 10, blood was collected for serum low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol measurements and homeostatic assessment model for insulin resistance (HOMA-IR) calculation. Cardiomyocyte hypertrophy and fibrosis were assessed by histology. Left ventricular expressions of selected genes associated with metabolism, inflammation, and stress response were investigated by qPCR.

Results
Both HFD/APOB-100 males and females developed obesity and hypercholesterolemia; however, only males showed insulin resistance. ET did not change these metabolic parameters. HFD/APOB-100 males showed echocardiographic signs of mild HF with dilated ventricles and thinner walls, whereas females presented the beginning of left ventricular hypertrophy. In response to ET, SD/WT males developed increased left ventricular volumes, whereas females responded with physiologic hypertrophy. Exercise-trained HFD/APOB-100 males presented worsening HF with reduced ejection fraction; however, ET did not change the ejection fraction and reversed the echocardiographic signs of left ventricular hypertrophy in HFD/APOB-100 females. The left ventricular expression of the leptin receptor was higher in females than males in the SD/WT groups. Left ventricular expression levels of stress response-related genes were higher in the exercise-trained HFD/APOB-100 males and exercise-trained SD/WT females than exercise-trained SD/WT males.

Conclusions
HFD/APOB-100 mice showed sex-specific cardiovascular responses to MetS and ET; however, left ventricular gene expressions were similar between the groups except for leptin receptor and several stress response-related genes.
Text mining-based measurement of precision of polysomnographic reports as basis for intervention
Authors: Baty Florent , Hegermann Jemima , Locatelli Tiziana , Rüegg Claudio , Gysin Christian , Rassouli Frank , Brutsche Martin 
Published: January 2022

Abstract
Background
Text mining can be applied to automate knowledge extraction from unstructured data included in medical reports and generate quality indicators applicable for medical documentation. The primary objective of this study was to apply text mining methodology for the analysis of polysomnographic medical reports in order to quantify sources of variation – here the diagnostic precision vs. the inter-rater variability – in the work-up of sleep-disordered breathing. The secondary objective was to assess the impact of a text block standardization on the diagnostic precision of polysomnography reports in an independent test set.

Results
Polysomnography reports of 243 laboratory-based overnight sleep investigations scored by 9 trained sleep specialists of the Sleep Center St. Gallen were analyzed using a text-mining methodology. Patterns in the usage of discriminating terms allowed for the characterization of type and severity of disease and inter-rater homogeneity. The variation introduced by the inter-rater (technician/physician) heterogeneity was found to be twice as high compared to the variation introduced by effective diagnostic information. A simple text block standardization could significantly reduce the inter-rater variability by 44%, enhance the predictive value and ultimately improve the diagnostic accuracy of polysomnography reports.

Conclusions
Text mining was successfully used to assess and optimize the quality, as well as the precision and homogeneity of medical reporting of diagnostic procedures – here exemplified with sleep studies. Text mining methodology could lay the ground for objective and systematic qualitative assessment of medical reports.
On torque computation in electric machine simulation by harmonic mortar methods
Authors: Egger Herbert , Harutyunyan Mané , Löscher Richard , Merkel Melina , Schöps Sebastian 
Published: January 2022

AbstractThe use of trigonometric polynomials as Lagrange multipliers in the harmonic mortar method enables an efficient and elegant treatment of relative motion in the stator-rotor coupling of electric machine simulation. Explicit formulas for the torque computation are derived by energetic considerations, and their realization by harmonic mortar finite element and isogeometric analysis discretizations is discussed. Numerical tests are presented to illustrate the theoretical results and demonstrate the potential of harmonic mortar methods for the evaluation of torque ripples.
Initial evaluation of [18F]-FACBC for PET imaging of multiple myeloma
Authors: Morath Volker , Heider Michael , Mittelhäuser Markus , Rolbieski Hannes , Stroh Jacob , Calais Jérémie , Eiber Matthias , Bassermann Florian , Weber Wolfgang A. 
Published: January 2022

Abstract
Rationale
Multiple myeloma (MM) cells synthesize large amounts of paraproteins, making radiolabeled amino acids promising candidates for PET imaging of MM patients.

Methods
We compare tumor uptake of the two amino acid analogs [18F]-fluoroethyltyrosine and [18F]-FACBC in a MM xenograft model and show the feasibility of PET imaging with [18F]-FACBC in a MM patient.

Results
Preclinically [18F]-FACBC showed superior performance, mainly due to the uptake via the ASC-system. In a subsequent proof-of-concept investigation [18F]-FACBC PET was performed in a MM patient. It allowed identification of both lesions with and without CT correlate (SUVmean 8.0 or 7.9) based on higher uptake compared to normal bone marrow (SUVmean 5.7). Bone signal was elevated compared to non-MM patients, and, thus [18F]-FACBC potentially allows the assessment of bone marrow infiltration.

Conclusion
The FDA/EMA approved PET agent [18F]-FACBC is promising for imaging MM and should be further evaluated in prospective clinical studies.
Humoral immune response induced with dengue virus-like particles serotypes 1 and 4 produced in silkworm
Authors: Utomo Doddy Irawan Setyo , Pambudi Sabar , Park Enoch Y. 
Published: January 2022

AbstractDengue is an arboviral disease, which threatens almost half the global population, and has emerged as the most significant of current global public health challenges. In this study, we prepared dengue virus-like particles (DENV-LPs) consisting of Capsid-premembrane-envelope (CprME) and premembrane-envelope (prME) polypeptides from serotype 1 and 4, which were expressed in the silkworms using Bombyx mori nucleopolyhedrovirus (BmNPV) bacmid. 1CprME, 1prME, 4CprME, and 4prME expressed proteins in hemolymph, and the molecular weight of the purified proteins was 55 kDa, respectively. The purified polypeptides formed spherical Dengue virus-like particles (DENV-LPs) with ~ 30–55 nm in diameter. The immunoelectron microscopy (IEM) images revealed antigens to the surface of a lipid bilayer of DENV-LPs. The heparin-binding assay shows a positive relationship between absorbance and E protein domain III (EDIII) quantity, which is supported by the isothermal titration calorimetry assay. This indicates a moderate binding affinity between heparin and DENV-LP. The high correlation between patient sera and DENV-LP reactivities revealed that these DENV-LPs shared similar epitopes with the natural dengue virus. IgG elicitation studies in mice have demonstrated that DENV-LPs/CPrMEs elicit a stronger immune response than DENV-LP/prMEs, which lends credence to this claim.
Organ donation in the time of COVID-19: the Israeli experience one year into the pandemic—ethical and policy implications
Authors: Katvan Eyal , Cohen Jonathan , Ashkenazi Tamar 
Published: January 2022

Abstract
Purpose
To present the response of the Israel National Transplantation Center (NTC) to the evolving challenge of COVID-19, the impact on deceased organ donation and living organ kidney donation during 2020, and resultant policy and ethical implications.

Methods
Data collected included (i) for deceased donors, the total number of potential organ donors, if hospitalized in ICU or general ward, cause of death, number of family authorizations and refusals, number of actual donors, number of organs transplanted/donor and total number of transplants performed; (ii) for living-kidney-donors (related or altruistic), the number of procedures performed; and (iii) the number of patients registered on the national organ waiting-list.

Results
Following the first case (February 2020), deceased organ donation continued uninterrupted. The total number of potential donors was similar to 2019 (181 vs. 189). However, the number of families approached for donation decreased significantly (P = 0.02). This may be attributed to COVID-19-imposed limitations including fewer brain death determinations due to limited possibilities for face-to-face donor coordinator-donor family interactions providing emotional support and visual explanations of the medical situation. Fewer donors were admitted to ICU (P = 0.1) and the number of organs retrieved/donor decreased (3.8/donor to 3.4/donor). The overall result was a decrease of 24.2% in the number of transplant procedures (306 vs. 232). Living kidney donation, initially halted, resumed in May and the total number of procedures increased compared to 2019 due to a significant increase in altruistic donations (P < 0.0001), while the number of related-living donations decreased.

Conclusion
This study of organ donation during a crisis has informed the introduction of policy changes in the NTC including the necessity to mobilize rapidly a “war room”, the use of innovative virtual tools for contact-less communication, and the importance of cooperation with hospital authorities in allocating scarce health-care resources. Finally, the pandemic highlighted and intensified ethical considerations, such as under what circumstances living kidney donation be continued in the face of uncertainty, and what information to provide to altruistic donors regarding a prospective recipient, in particular whether all options for related living donation have been exhausted. These should be addressed now.
Performance evaluation of publish-subscribe systems in IoT using energy-efficient and context-aware secure messages
Authors: Ferraz Junior Norisvaldo , Silva Anderson A.A. , Guelfi Adilson E. , Kofuji Sergio T. 
Published: January 2022

Abstract
Background
The Internet of Things (IoT) enables the development of innovative applications in various domains such as healthcare, transportation, and Industry 4.0. Publish-subscribe systems enable IoT devices to communicate with the cloud platform. However, IoT applications need context-aware messages to translate the data into contextual information, allowing the applications to act cognitively. Besides, end-to-end security of publish-subscribe messages on both ends (devices and cloud) is essential. However, achieving security on constrained IoT devices with memory, payload, and energy restrictions is a challenge.

Contribution
Messages in IoT need to achieve both energy efficiency and secure delivery. Thus, the main contribution of this paper refers to a performance evaluation of a message structure that standardizes the publish-subscribe topic and payload used by the cloud platform and the IoT devices. We also propose a standardization for the topic and payload for publish-subscribe systems.

Conclusion
The messages promote energy efficiency, enabling ultra-low-power and high-capacity devices and reducing the bytes transmitted in the IoT domain. The performance evaluation demonstrates that publish-subscribe systems (namely, AMQP, DDS, and MQTT) can use our proposed energy-efficient message structure on IoT. Additionally, the message system provides end-to-end confidentiality, integrity, and authenticity between IoT devices and the cloud platform.
Perceptions and experiences toward extended-release buprenorphine among persons leaving jail with opioid use disorders before and during COVID-19: an in-depth qualitative study
Authors: Cheng Anna , Badolato Ryan , Segoshi Andrew , McDonald Ryan , Malone Mia , Vasudevan Kumar , Badiei Beita , Sugarman Allison , Macdonald Ross , Mangat Jasdeep , Giftos Jonathan , Lee Joshua D. , Tofighi Babak 
Published: January 2022

Abstract
Background
Extended-release buprenorphine (XRB) offers a novel approach to sustained monthly treatment for people who use opioids in criminal justice settings (CJS). This study explores the experiences of adults receiving XRB as a jail-to-community treatment.

Methods and findings
In-depth qualitative interviews were conducted among adult participants with opioid use disorder (OUD; n  = 16) who were recently released from NYC jails and maintained on XRB after switching from daily sublingual buprenorphine (SLB). Interviews elaborated on the acceptability and barriers and facilitators of XRB treatment pre- and post-release. Interviews were audio recorded, transcribed, and analyzed for content related to factors influencing XRB treatment uptake and community reentry. Important themes were grouped into systems, medication, and patient-level factors. Key systems-level factors influencing initiation of XRB in jail included an alternative to perceived stigmatization and privacy concerns associated with daily in-jail SLB administration and less concerns with buprenorphine diversion. In-jail peer networks positively influenced participant adoption of XRB. XRB satisfaction was attributed to reduced in-jail clinic and medication administration visits, perceived efficacy and blockade effects upon the use of heroin/fentanyl following release, and averting the risk of criminal activities to fund opioid use. Barriers to retention included post-injection withdrawal symptoms and cravings attributed to perceived suboptimal medication dosing, injection site pain, and lack of in-jail provider information about the medication.

Conclusion
Participants were generally favorable to XRB initiation in jail and retention post-release. Further studies are needed to address factors influencing access to XRB in criminal justice settings, including stigma, ensuring patient privacy following initiation on XRB, and patient-, provider-, and correctional staff education pertaining to XRB.
Trial Registration ClinicalTrials.gov Identified: NCT03604159.
Differences in on-ground and aloft conditions explain seasonally different migration paths in Demoiselle crane
Authors: Galtbalt Batbayar , Batbayar Nyambayar , Sukhbaatar Tuvshintugs , Vorneweg Bernd , Heine Georg , Müller Uschi , Wikelski Martin , Klaassen Marcel 
Published: January 2022

AbstractBackgroundAlthough some migratory birds may take different routes during their outbound and inbound migration, the factors causing these differential migrations to and from the breeding grounds, have rarely been investigated. In Northeast Asia, Demoiselle crane (Anthropoides virgo) performs one of the most extreme “loop” migrations known to date. During outbound migration, they cross the Himalayas to non-breeding sites in northwest India. Contrastingly, during inbound migration to the breeding grounds, they fly around the western end of the Himalayas. We hypothesise that differences in prevailing environmental conditions aloft and/or on-ground during both seasonal migrations are at the core of this phenomenon.MethodsBased on the tracking data of 16 individuals of tagged Demoiselle crane, we compared conditions during actual migration with those of simulated “reverse” migration (i.e. by adding 180 degrees to the flight direction and adding and subtracting half a year to the timestamps of outbound and inbound migration, respectively).ResultsThe comparison of actual and simulated “reverse” migration indicated that cranes would have encountered poorer aloft (wind support and thermal uplift) and on-ground conditions (temperature) if they had migrated in a reverse outbound migration and poorer on-ground conditions (Normalised Difference Vegetation Indexes [NDVI]) if they had migrated in a reverse inbound direction.ConclusionsOur analyses suggest that both on-ground and aloft conditions play a key role in explaining Demoiselle cranes’ loop migration, during the periods that they chose to use these alternative routes. Knowledge on the determinants of (differential) migration routes allow predicting migration decisions and may be critical in mitigating global change effects on animal migrations.
Identification of the spatio-temporal and fluvial-pluvial sources of flood inundation in the Lower Mekong Basin
Authors: Try Sophal , Sayama Takahiro , Oeurng Chantha , Sok Ty , Ly Steven , Uk Sovannara 
Published: January 2022

AbstractIdentification of the sources of the spatio-temporal information of flooding is important for flood control and understanding the water dynamic. Flood disasters are generally caused by two main sources: fluvial and pluvial flooding. However, there is a gap in information and challenge of such particular information in the Mekong River Basin (MRB) known as the largest river basin in Southeast Asia. This paper aims to analyze the spatio-temporal hydrograph separations of flooding and to determine the fluvial and pluvial sources of inundation water in the Lower Mekong Basin (LMB) by using a distributed rainfall–runoff–inundation (RRI) model and time–space accounting scheme (T–SAS) method. This study focuses on the two major flood events in 2000 and 2011, whose characteristics were different. The one in 2000 was long in terms of flood duration and it was the historically largest annual total flood water with twice the peak times in July and September. The 2011 flood had the highest flooded water during the peak time; however, its annual total flood water was less than the one in 2000. The results of spatio-temporal sources of flooding indicated that during the flow peak time in 2000 and 2011, the flow at Kratie was mainly contributed by 30-day (67%) and 100-day (98%) precipitation from the upstream. The drainage area of the MRB in China, northern Lao PDR, southern Lao PDR and eastern Thailand, and Cambodia and Vietnam contributed to peak flood at Kratie by 13%, 27%, 33%, and 27% for the 2000 flood and 12%, 33%, 38%, and 16% for the 2011 flood. The source of inundated water in the LMB was derived from upstream flow (fluvial source) of 35–36% and local rainfall (pluvial source) of 64–65%. Even though flood events in 2000 and 2011 had different characteristics, the sources of flood inundation in the LMB for both events were majorly from the local rainfall rather than the upstream flow. The large annual flood volume and long during of flooding in 2000 caused severe total economic damages up to 517 million US$ in the LMB countries (Cambodia, Lao PDR, Thailand, and Vietnam), while the high peak inundated water in 2011 with shorter flood duration caused damages of 493 million US$.
Preparing early educators as frontline leaders and change agents with a leadership development initiative
Authors: Lee Yujin , Douglass Anne , Zeng Songtian , Wiehe Lopes Amanda , Reyes Arazeliz 
Published: January 2022

AbstractThe present study examined the impact of a leadership development program, Leading for Change (LfC) that focused on building the capacity of early educators to lead change as frontline leaders and change agents. Bringing together a relational-entrepreneurial leadership theory lens, the LfC was designed to foster early educators’ leadership mindset, knowledge, and skills that could potentially bring a long-lasting impact on many aspects of the early care and education (ECE) field. With a sample of 31 racially and linguistically diverse early educators, the present study compared participants’ entrepreneurial mindset, leadership competencies, and capacity to act as change agents and leaders before and after the LfC program. Results showed that participants’ perceptions of themselves as leaders were increased after completing the LfC. They also demonstrated more confidence in their own ability to drive positive change where they work and more broadly in the ECE field. Findings from this study suggest that the relational-entrepreneurial leadership approach taps into early educators’ insights, passions, and knowledge and equips them to participate in leadership for quality improvement and positive change.