bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geochemical characteristics of biotite and apatite from the Zhongdian porphyry Cu deposit belt in northwest Yunnan, China: An indicator of halogen fugacity and mineralization
Authors: Pan Yanning , Dong Guochen , Tsunogae Toshiaki , Wang Peng , Li Xuefeng , Dong Pengsheng 
Published: August 2022

Abstract
Copper mineralization at the Pulang (PL) super large porphyry deposit, Langdu (LD) medium-sized porphyry-skarn deposit and Songnuo (SN) porphyry prospect, Zhongdian Island, northwest Yunnan, China, is closely related to the emplacement of quartz monzonite porphyries. The chemical composition of biotite and apatite from those porphyries were analyzed to constrain the halogen fugacity and its control on mineralization. Our electron microprobe data show that biotites from PL deposit have higher MgO, SiO2, TiO2 and F content than that from LD or SN. In comparison to LD and SN, PL also display higher Mg (apfu) value and lower AlⅥ (apfu) in bitotite and higher F content but lower SO3 content and Ce2O3/ Y2O3 ratio in apatite. Application of Ti in biotite thermometry and apatite-biotite geothermometer shows that the crystallization temperature of biotite from PL is higher than that from SN or LD. The results suggest that oxygen fugacity and the magmatic sulfur and H2O contents couldn’t efficiently distinct PL from LD and SN. However, the halogen chemistry of biotite from PL is distinctly different from that from LD or SN by its lower IV (F), indicating that mineralized quartz monzonite porphyries from PL is formed in the late magmatic stage than that from LD and SN. And the mineralized porphyries display a remarkable negative linear (r = -0.96) in the ratio of log (f HF/f HCl) and log (f H2O/f HF), which can effectively distinguish PL from LD and SN. Compared with other porphyry Cu systems, only in mineralized systems, there is a remarkable positive linear relationship between IV (Cl) and log (f H2O/f HCl) ratios. Besides, the linear slope and intercept for log (f H2O/f HCl) ratios and IV (Cl) of biotite from potassic and phyllic alteration zone is significantly higher than those from other parts of the porphyries.
Toward Fast Belief Propagation for Distributed Constraint Optimization Problems via Heuristic Search⋆
Authors: Gao Junsong , Chen Ziyu , Chen Dingding , Zhang Wenxin , Li Qiang 
Published: August 2022

Abstract
Belief propagation (BP) approaches, such as Max-sum and its variants , are important methods to solve large-scale Distributed Constraint Optimization Problems (DCOPs). However, these algorithms face a huge challenge since their computational complexity scales exponentially with the arity of each constraint function. Current accelerating techniques for BP use sorting or branch-and-bound (BnB) strategy to reduce the search space. However, the existing BnB-based methods are mainly designed for specific problems, which limits their applicability. On the other hand, though several generic sorting-based methods have been proposed, they require significantly high preprocessing as well as memory overhead, which prohibits their adoption in some realistic scenarios. In this paper, we aim to propose a series of generic and memory-efficient heuristic search techniques to accelerate belief propagation. Specifically, by leveraging dynamic programming, we efficiently build function estimations for every partial assignment scoped in a constraint function in the preprocessing phase. Then, by using these estimations to build upper bounds and employing a branch-and-bound in a depth-first fashion to reduce the search space, we propose our first method called FDSP. Next, we enhance FDSP by adapting a concurrent-search strategy and leveraging the upper bounds as guiding information and propose its first heuristic variant framework called CONC-FDSP. Finally, by choosing to expand the partial assignment with the highest upper bound in each step of exploration, we propose the second heuristic variant of FDSP, called BFS-FDSP. We prove the correctness of our methods theoretically, and our empirical evaluations indicate their superiority for accelerating Max-sum in terms of both time and memory, compared with the state-of-the-art.
Metadichol® induced expression of neuronal transcription factors with Human fibroblast Dermal cells
Authors: Raghavan Palayakotai R 
Published: August 2022

Abstract

Background. Producing neurons from fibroblast cells has the potential to treat neurodegenerative diseases, characterized by neuron loss. Neurodegenerative diseases are a growing problem in the current aging, developed world populations. Metadichol® is a nontoxic nanoemulsion of long-chain lipid alcohols, currently available as an oral supplement. Methods and Findings. In this study, Metadichol® was used to treat human fibroblasts in vitro; we subsequently evaluated changes in the expression of neuronal transcription factors by qRT-PCR and immunoblotting. We observed increased expression of critical transcription factors for neuronal development, such as ASCL1, NGN2. ND2, NR4A2, LMX1A, LHX3. ISL1, and FOXA2. Conclusions. These data suggest that Metadichol® is a promising putative neuronal remodeling agent. Its current availability and safety profile suggest that it could be rapidly available for in vivo testing, impossible thus far.
Wearable Sensor for Measuring Unsupported Sitting Balance in Humans with Cervical Spinal Cord Injury
Authors: Lei Yuming , Rios Victoria , Ji Jessica , Duhon Brandon , Boyd Hunter 
Published: August 2022

Abstract
STUDY DESIGN: Cross-sectional study. OBJECTIVES: To investigate unsupported sitting balance using a wearable inertial measurement unit (IMU)-based sensor in persons with cervical spinal cord injury (cSCI). SETTING: A research lab in the United States of America. METHODS: cSCI participants and healthy controls maintained postural stability during unsupported sitting with eyes open or closed. Cumulative sway motion was calculated using the accelerometer data recorded by the head-mounted IMU sensor. Postural regulatory strategy following cSCI was investigated by analyzing the normalized power spectral density (PSD) in four frequency bands: 0-0.1 Hz (arising from visual regulation), 0.1-0.5 Hz (vestibular regulation), 0.5-1 Hz (cortical structures), and 1> Hz (proprioception and muscle control). RESULTS: We found significant increases in postural sway in cSCI participants compared with healthy participants during unsupported sitting. Normalized PSD was significantly increased in the low-frequency bands (0-0.1 Hz and 0.1-0.5 Hz) but decreased in the high-frequency band (1> Hz) for cSCI participants compared with healthy participants. CONCLUSIONS: cSCI participants relied less on proprioception and muscle control to maintain sitting balance than healthy controls. In contrast, the contributions of visual and vestibular systems to sitting balance were augmented following cSCI. These findings indicated that the change in postural regulatory strategy was ineffective in maintaining postural stability during unsupported sitting, highlighting the importance of proprioception and muscle control in seated postural stability in persons with cSCI.
Shaft resistance capacity of axially loaded piles in cohesive-frictional soils under static or pseudo-static conditions based on ground parameters
Authors: Pantelidis Lysandros 
Published: August 2022

Abstract
According to the current practice, the unit shaft resistance of piles based on ground parameters is calculated with the the α-method or the β-method, for total or effective stress conditions respectively. Indeed, these two methods are included in the prEN1997-3:2021 draft standard. And while the physics behind these methods is adequate for calculating the shaft resistance of piles in clays and sands for total and effective stress analysis respectively, the main difficulty in applying the effective stress approach in clays is to estimate the radial effective stress acting on the pile. In the present paper this is addressed by a proposed earth pressure at-rest coefficient, applicable to cohesive-frictional soils and both horizontal and vertical pseudo-static conditions. Comparison examples show excellent agreement of the analytically derived shaft resistance capacities with the respective numerical ones. Regarding seismic conditions it is noted that, for the case of axially loaded piles the horizontal component of the seismic excitation does not affect the shaft resistance capacity of piles, while the vertical component could be neglected as acting favorably. Finally, it is mentioned that the proposed method is a general c-φ procedure, applicable also for purely cohesive and cohesionless soils.
Hospital bed capacity across in Tunisia hospital during the first four waves of the COVID-19 pandemic: A descriptive analysis
Authors: miled slimane ben , borgi chiraz , somrani naoufel , hsairi mohamed , kebir amira 
Published: August 2022

Abstract
Background: On March 11, 2020, WHO announced that the COVID-19 epidemic had passed the pandemic stage, indicating its spread over several continents. Tunisia's containment and targeted screening strategy corresponded to the first WHO guidelines. Since then, public health policy has been more flexible and focused on the management of hospital beds. Objective: Our aims are to analyze bed occupancies for public hospitals and the time delay response from the health care system in regard to the epidemiological situation. Methods: We have analyzed the evolution of daily cases in relation to the different NPI actions undertaken by the Tunisian Government between March 2019 and February 2022 using the CoMo model. We have also studied the flexibility of the O2 and ICU public hospital bed occupancies. We have used three distinct indices to assess this flexibility: the Ramp Duration Until the Peak (RDUP), which measures the duration of the wave/bed allocation effort. The Ramp Growth Until the Peak (RGUP), measures the peak height, and Ramp Rate Until the Peak (RRUP) measures the growth rate of the wave. Also, in order to evaluate the government response efficacy, we have calculated the time delay at the start (resp. at peak) of each two wave. Results: 1. The evolution of the epidemic in Tunisia was divided into two phases, the first of which corresponded to the initial wave, during which the pandemic was controlled due to very strong NPI actions. The second phase was distinguished by a progressive relaxation of measures and an increase in wave intensity. 2. ICU bed availability has followed the demand for beds, while ICU bed occupancy has always been higher than 85% with a maximum of 97%. 3. In terms of bed distribution, the government's response was slow (9.4 days for the 02 beds and 18.2 days for the ICU beds). The same may be said for the reaction in terms of bed reallocation in the original departments (16 days for ICU beds and 10.6 days for O2 beds).. Conclusion: We were able to examine the responsiveness of the system as a whole for all of Tunisia's public hospitals by measuring the flexibility and bed margin. With this research, decision-makers will be able to assess their response capabilities in the event of a current pandemic, as well as a future one.
Investigation of the Presence of Atopy in Pediatric Patients Visiting the Pediatric Cardiology Department due to Chest Pain
Authors: Duksal Fatma , Dogan Melih Timucin 
Published: August 2022

Abstract
Background
Chest pain is one of the important reasons for hospital admissions among children. However, it is known that the cause of chest pain is mostly not because of cardiac origin
Objectives
It was aimed to investigate asthma and other atopic diseases in children with chest pain that is not originated from cardiac problems.
Patients and Methods:
Children aged 6–18 years who were investigated for chest pain in the pediatric cardiology and pediatric allergy-immunology departments were included in the study. Hematological parameters, pulmonary function tests and skin prick tests were performed. Atopic diseases and existence of environmental factors (smoking exposure, presence of pet, stove use, wool use and mold) had been questioned.
Results
The non-cardiac chest pain group (Group 1) included 88 children (female: 53.4%) and mean age of 11.92 ± 3.35 years; the control group (Group 2) included 29 children (female: 53.8%) and 11.38 ± 1.95 years (p > 0.05). Family history of atopy (22.72%) and skin prick test positivity (28.4%) were higher in group 1 than group 2 (p = 0.006; p = 0.017 respectively). The presence of environmental factors except mold was significantly higher in group 1 (54.5%) than group 2 (3.4%) (p = 0.000). Asthma and allergic rhinitis were diagnosed in 44.32% and 9.09% of them. Idiopathic chest pain, musculoskeletal system disorders, gastroesophageal reflux and pneumonia were found in 23.86%, 11.36%, %7.95 and 3.41% of group 1 respectively.
Conclusions
In this study, the most common cause of non-cardiac chest pain was asthma, while idiopathic chest pain was the second most common. A detailed history and careful physical examination will accurately establish the cause of chest pain in most children.
Anticancer activity of ethanol and ethyl acetate extracts of Avicennia marina leaves on breast, ovarian and cervical cancer cell lines
Authors: Afshar Alireza , Khoradmehr Arezoo , Zare Masoud , Baghban Neda , Mohebbi Gholamhossein , Barmak Alireza , Khatami Mohsen , Mahmudpour Mehdi , Daneshi Adel , Bargahi Afshar , Azari Hossein , Nabipour Iraj , Ullah Mujib , Anvari Morteza , Tamadon Amin 
Published: August 2022

Abstract
Avicennia marina, the gray mangrove, is an herbal source of bioactive anticancer compounds. In the current study, the anticancer activity of ethanol and ethyl acetate extracts of A. marina leaves were aimed to be evaluated. To do that, some assessments including phytochemical, GC-MS, cell proliferation, viability, cycle, western blot and computational modeling analysis were performed for evaluation of their anticancer activity on breast, ovarian and cervical cancer cell lines. The results demonstrated ethanol and ethyl acetate extracts of A. marina leaves had high phenolic and flavonoid contents. In GC-MS analysis of the extracts, anticancer compounds were detected. Moreover, the MTT and cell viability assays showed anti-proliferative activity and decrease in cell viability after treatment of MCF-7, OVCAR3, and HeLa cell lines with both extracts, separately. In addition, in the cell cycle analysis the cell cycle arrest was observed in MCF-7. Moreover, the western blot analysis showed that the pro-apoptotic cell effectors such as Bax and caspase-1, -3, and -7 increased. Computational results of affinity of ligands detected by GC-MS compounds and stimulated apoptosis effectors detected by western blot showed five molecules in A. marina leaves playing role in OVCAR3 and HeLa apoptosis. In conclusion, the ethanol and ethyl acetate extracts of A. marina leaves have anticancer effects. The ethanol extract induced cell cycle arrest in the breast cancer cell line and the ethyl acetate extract induced apoptotic mechanisms in ovarian and cervical cancer cell lines; that’s how they decreased cancer cells’ survival and viability.
Mineral evolution and mineral niches of ammonium sulfates: The case of Pastora mine, Aliseda, Spain
Authors: López Ángel Crespo , Pimentel Carlos , Pina Carlos M. 
Published: August 2022

Abstract
The uncommon association of ammonium sulfates identified in the Pastora abandoned mine is the result of a complex mineral evolution. By means of dissolution-(re)crystallization reactions operating during long periods of time, ammonium minerals “adapt” to local spatiotemporal changes in physico-chemical conditions. We found that during such an evolution, seasonal variations in temperature and humidity, the relative solubility of mineral species, and the presence of organic matter play an important role. In addition, our study shows the existence of “mineral niches” and “mineral seasonality,” which can be explained on the basis of the “mineral ecology” concept introduced by Hazen et al. (2015). Our investigation of the formation of hydrated sulfates, particularly of ammonium sulfates, might be of importance for identifying the existence of life in mineral formation environments.
Parenting-Related Self-Compassion Scale (P-SCS): Adaptation and Validation in Indonesian Parents
Authors: Hasyyati Bewizta Maurilla , Abidin Fitri Ariyanti 
Published: August 2022

Background:
Self-Compassion Scale (SCS) is a self-report instrument of self-compassion in the general population. When applied to the parenting context, SCS has limitations in reflecting the difficulties parents face due to the specific characteristic in parenting. This restriction makes it not fully reflect the parenting self-compassion. Therefore, the present study aims to adapt and validate the SCS-modification in parenting (P-SCS) using six steps based on ITC guidance.

Methods:
We analyzed construct validity using factor structure, convergent validity with Rosenberg self-esteem scale (RSES), and reliability using internal consistency. Two hundreds and eight parents were recruited for this study (Mean age = 37.32, SD = 5.113, Female = 191, Male = 17).

Results:
CFA analysis showed that the P-SCS has a fairly good fit model (X2 / df = 1.781; RMSEA = 0.061; GFI = 0.87; CFI = 0.96; NFI = 0.92; IFI = 0.96). Second-order CFA revealed that the six-factor analysis factor approach is more appropriate in analyzing self-compassion compared to the higher-order model. P-SCS has a convergent validity through a moderate correlation with the total RSES score (r = 0.59, p = 0.00) and fairly good reliability (Cronbach's Alpha = 0.870).

Conclusion:
In conclusion, P-SCS is a reliable and valid measure of self-compassion in the Indonesian parenting context.
Deployment of a Free-Text Analytics Platform at a UK National Health Service Research Hospital: CogStack at University College London Hospitals
Authors: Noor Kawsar , Roguski Lukasz , Bai Xi , Handy Alex , Klapaukh Roman , Folarin Amos , Romao Luis , Matteson Joshua , Lea Nathan , Zhu Leilei , Asselbergs Folkert W , Wong Wai Keong , Shah Anoop , Dobson Richard JB 
Published: August 2022

Background
As more health care organizations transition to using electronic health record (EHR) systems, it is important for these organizations to maximize the secondary use of their data to support service improvement and clinical research. These organizations will find it challenging to have systems capable of harnessing the unstructured data fields in the record (clinical notes, letters, etc) and more practically have such systems interact with all of the hospital data systems (legacy and current).

Objective
We describe the deployment of the EHR interfacing information extraction and retrieval platform CogStack at University College London Hospitals (UCLH).

Methods
At UCLH, we have deployed the CogStack platform, an information retrieval platform with natural language processing capabilities. The platform addresses the problem of data ingestion and harmonization from multiple data sources using the Apache NiFi module for managing complex data flows. The platform also facilitates the extraction of structured data from free-text records through use of the MedCAT natural language processing library. Finally, data science tools are made available to support data scientists and the development of downstream applications dependent upon data ingested and analyzed by CogStack.

Results
The platform has been deployed at the hospital, and in particular, it has facilitated a number of research and service evaluation projects. To date, we have processed over 30 million records, and the insights produced from CogStack have informed a number of clinical research use cases at the hospital.

Conclusions
The CogStack platform can be configured to handle the data ingestion and harmonization challenges faced by a hospital. More importantly, the platform enables the hospital to unlock important clinical information from the unstructured portion of the record using natural language processing technology.
Conversational Agents in Health Care: Scoping Review of Their Behavior Change Techniques and Underpinning Theory
Authors: Martinengo Laura , Jabir Ahmad Ishqi , Goh Westin Wei Tin , Lo Nicholas Yong Wai , Ho Moon-Ho Ringo , Kowatsch Tobias , Atun Rifat , Michie Susan , Tudor Car Lorainne 
Published: August 2022

Background
Conversational agents (CAs) are increasingly used in health care to deliver behavior change interventions. Their evaluation often includes categorizing the behavior change techniques (BCTs) using a classification system of which the BCT Taxonomy v1 (BCTTv1) is one of the most common. Previous studies have presented descriptive summaries of behavior change interventions delivered by CAs, but no in-depth study reporting the use of BCTs in these interventions has been published to date.

Objective
This review aims to describe behavior change interventions delivered by CAs and to identify the BCTs and theories guiding their design.

Methods
We searched PubMed, Embase, Cochrane’s Central Register of Controlled Trials, and the first 10 pages of Google and Google Scholar in April 2021. We included primary, experimental studies evaluating a behavior change intervention delivered by a CA. BCTs coding followed the BCTTv1. Two independent reviewers selected the studies and extracted the data. Descriptive analysis and frequent itemset mining to identify BCT clusters were performed.

Results
We included 47 studies reporting on mental health (n=19, 40%), chronic disorders (n=14, 30%), and lifestyle change (n=14, 30%) interventions. There were 20/47 embodied CAs (43%) and 27/47 CAs (57%) represented a female character. Most CAs were rule based (34/47, 72%). Experimental interventions included 63 BCTs, (mean 9 BCTs; range 2-21 BCTs), while comparisons included 32 BCTs (mean 2 BCTs; range 2-17 BCTs). Most interventions included BCTs 4.1 “Instruction on how to perform a behavior” (34/47, 72%), 3.3 “Social support” (emotional; 27/47, 57%), and 1.2 “Problem solving” (24/47, 51%). A total of 12/47 studies (26%) were informed by a behavior change theory, mainly the Transtheoretical Model and the Social Cognitive Theory. Studies using the same behavior change theory included different BCTs.

Conclusions
There is a need for the more explicit use of behavior change theories and improved reporting of BCTs in CA interventions to enhance the analysis of intervention effectiveness and improve the reproducibility of research.