bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decision to Delivery Interval in Emergency Cesarean Section at Two Academic Hospitals in Yogyakarta and Central Java, Indonesia
Authors: Prawitasari Shinta , Widyandana Doni , Hakimi Mohammad , Utarini Adi 
Published: February 2022

Background: The international guideline suggests that the ideal DDI is 30 minutes for grade 1 and grade 2 CS, but they are still hardly achieved. Therefore, the main purpose of this study was to determine the DDI for grade 1 and 2 CS, and its determinants in two academic hospitals.Methods: A prospective cohort study was conducted using pregnant women who underwent grade 1 and 2 emergency CS. Data regarding demographic characteristics of the subjects were extracted from the medical record, while DDI and its components were measured by direct observation. Odds ratio was used to determine the association between DDI and its determinants.Results: The median DDI for grade 1 and 2 CS in the main academic hospital were 112.5 minutes and 181 minutes respectively, longer than their duration in the affiliated hospital with 80 minutes for grade 1 CS and 104 minutes for grade 2 CS. The significant determinants for a 75-minute DDI in the main academic hospital were grade of CS (OR: 0.12; 95%CI: 0.01-1.05; p: 0.047), indication of CS (OR: 0.77; 95%CI: 0.6-0.89; p: 0.014), and anesthesiologist response time (OR: 9.18; 95%CI: 2.21-38.13; p: 0.001), while in the affiliated academic hospital, operating room waiting time was the only significant determinants (OR: 6.18; 95%CI: 2.07-18.48; p: 0.001).Conclusions: DDI for emergency CS still exceeded the standard in academic hospitals with different determinants causing the delay. Strengthening interprofessional collaboration should be implemented systematically.Â Â
Primary infertility of male and female factors, polycystic ovary syndrome and oligoasthenoteratozoospermia dominate the infertile population in agricultural and industrial areas in Karawang Regency, West Java Province, Indonesia
Authors: Guyansyah Assangga , Wratsangka Raditya , Dhanardono Denny , Ghazali Muhammad Farid , Edy Hosea Jaya , Widyatama Haryo Ganeca , Kusumaningrum Dietha , Tjahyadi David , Parwanto Edy 
Published: February 2022

Introduction: Indonesia is a country with a large agricultural and industry, known to utilize various types of pesticides, as well as several other industries with uncontrolled pollution levels distributed across the nation. Besides, numerous studies have stated the adverse effects of chemicals substances used in daily life and industrial waste on the health of living things, including humans. This study aimed to determine the infertility characteristic in the agricultural and industrial areas in Karawang Regency, West Java Province, Indonesia.Methods: The study was conducted retrospectively on medical records. Therefore, this study determined the infertility characteristics based on sperm analysis, the etiology of the causes of infertility in female, and the diagnosis of infertility. Data collection was obtained from patients' medical records in the Infertile Poly of Mitra Bunda Amanda Hospital Karawang, Karawang Regency, West Java Province, Indonesia.Â Result: The results showed infertility was most prevalent in males aged 30-40 years (55.79%) and females below 30 years (61.05%). Furthermore, the male and female's most prevalent educational qualification (33.68% and 36.84%, respectively) was discovered to be high school diploma. In terms of occupation, most male (56.84%) were laborers, while the female was mostly housewives (36.84%). Meanwhile, oligoasthenoteratozoospermia was the most analyzed sperm type (33.68%), and polycystic ovary syndrome was the most common etiology of infertility in females (26.32%). The most prevalent diagnosis was primary infertility factors, male and female (45.26%).Conclusion: Primary infertility of male and female factors, polycystic ovary syndrome and oligoasthenoteratozoospermia dominate the infertile population in agricultural and industrial areas in Karawang Regency, West Java Province, Indonesia.
Root cause analysis of maternal deaths at Dr. Soetomo General Academic Hospital Surabaya, Indonesia in 2019
Authors: Desetyaputra Dimas Ryan , Prasetyo Budi , Damayanti Hanifa Erlin 
Published: February 2022

Introduction: Maternal mortality in Indonesia especially in dr. Soetomo General Hospital is still very high, and the biggest problem is obstetric complications. It is possible that the mother who has obstetric complications is safe and recovered or died. This study aimed to identify the root cause of maternal death at Dr. Soetomo General Academic Hospital in 2019.Methods: This is a descriptive retrospective study with the Root Cause Analysis method to analyze total of 87 maternal deaths at Dr. Soetomo General Academic Hospital in 2019.Results: There were 87 cases of maternal death at Dr. Soetomo General Academic Hospital in 2019. Direct maternal death was the leading cause of maternal death, contributing 59 cases (67.8%). From 59 cases, 31 cases (35.6%) direct maternal deaths were caused by preeclampsia/eclampsia. Contributing factors that influence maternal mortality are including organizational management, medical personnel, equipment, materials, & ward, environmental, and family barriers factors. Organizational management factors, the most common factor that causes maternal death is a poor information sharing system at the referring hospital, as many as 17 cases (27.4%). Medical personnel factors, maternal death was mostly caused by lack of knowledge and skills during antenatal care, as many as 42 cases (44.2%). Equipment, materials, and ward factors, the most common cause was the unavailability of the ward, contributing 5 cases (55.6%). Family barrier factors, most maternal deaths were caused by the families that did not understand about the emergency condition of the patient, as many as 52 cases (67.5%).Conclusion: The maternal deaths at Dr. Soetomo General Academic Hospital in 2019 were mostly caused by the family barrier factor which did not understand about patient’s emergency condition, followed by the medical personnel factor which was lack of knowledge and skills during antenatal care.
Subchronic toxicity of piperine in piper nigrum on the histology of the kidney, liver, and lungs of mice (Mus musculus L.)
Authors: Makiyah Sri Nabawiyati Nurul , Tasminatun Sri , Arsito Puguh Novi , Fauziah Khairina Nurul , Nugrahanti Dieny Rizka , Putriani Annisa 
Published: February 2022

Introduction: Piperine is a compound that has many health benefits, but piperin has toxic effects that endanger the human body. The purpose of this study was to determine the toxic dose of subchronic piperine administration using histology of the liver, kidneys, and lungs of mice (Mus musculus L).Method: This is a quasi-experimental research with posttest only control group design. Thirty male BALB/c mice were divided into five groups. Piperine was administered orally to the mice. The normal control group and four treatment groups at dosage of 17.5, 35, 70, and 140 mg/kg body weight for 21 days. At the day-22, the liver, kidneys, and lungs were removed and prepared using the HE staining technique. Scores of liver, kidney, and lung damage are recorded. The data was analyzed using one-way ANOVA with the post hoc Tukey test.Result: The liver histological damage score after administration of piperine doses of 35, 70, and 140 mg/kg significantly different from the control group. The kidney and lung damage scores after 140 mg/kg administration showed significant differences from the control group. The conclusion is piperine at dosage of 35, 70, and 140 mg/kg was toxic to the liver, and piperine at doses of 140 mg/kg was toxic to the kidney and lung histology of BALB/c mice.Conclusion: Piperine should not be used at doses of 35 mg/kg body weight or larger.
Dominant factors which affecting the quality of life of hypertension patients in rural and sub-urban area in Yogyakarta
Authors: Relawati Ambar , Kurniawan Movit 
Published: February 2022

Background: Hypertension is a condition where the systolic blood pressure result is 140 mmHg, and the diastolic blood pressure result is 90 mmHg. Uncontrolled blood pressure is one of the etiologies of the emergence of complications that will reduce the quality of life. It is necessary to measure the quality of life and to know the factors that affect the quality of life of people with hypertension as a benchmark to improve the welfare of life. This study aims to analyze the dominant factors affecting the quality of life of hypertension sufferers in rural and sub-urban areas in Yogyakarta.Method: This type of research is non-experimental with quantitative methods and correlational descriptive design. The approach used is cross sectional. Respondents in this study amounted to 85 respondents using the purposive sampling technique. This research was conducted in February-March 2021. The data analysis used was the frequency test and logistic regression test.Result: The dominant factor influencing the quality of life of hypertension sufferers in rural and sub-urban areas in Yogyakarta is medication adherence (OR=0.164).Conclusion: The dominant factor influencing the quality of life of hypertension sufferers in rural and sub-urban areas in Yogyakarta is medication adherence.
Persistence of anti-Salmonella O9 IgM as measured by Tubex® TF may contribute to the over-diagnosis of typhoid fever in endemic areas
Authors: Pranata I Wayan Adi , Diana Aly , Heryanto Marco R , Lukman Nurhayati , Kosasih Herman , Djauhari Hofiya , Butarbutar Deni PR , Widjaja Susana , Alisjahbana Bachti 
Published: February 2022

Background: Diagnosing typhoid fever definitively, using bone-marrow, blood or feces culture is either invasive, time-consuming, expensive, or complicated. Hence, clinicians often use clinical presentations and/or rapid diagnostic methods to examine the indirect evidence of Salmonella typhi infections. This study describes the proportion of typhoid fever, challenges of diagnosing typhoid fever, and the kinetics of anti-Salmonella O9 IgM.
Methods: During a prospective dengue study in Bandung, Indonesia, 1,431 febrile occurrences were observed among 2,978 adult volunteers over a four-year period. As typhoid fever is endemic and represents a major cause of febrile illness in this study area, acute- and convalescent-phase sera from 964 subjects that had been excluded for dengue and chikungunya infections, were tested with Tubex® TF. To observe the kinetics of anti-Salmonella O9 IgM, we tested sequential sera up to 260 days post-illness from 3 subjects.
Results: Based on Tubex® TF, 71 of 964 (7.4%) subjects had anti-Salmonella O9 IgM (score≥4) in their convalescent sera. Anti-Salmonella O9 IgM scores in convalescent sera increased compared to the acute sera in 36 subjects, indicating probable acute typhoid fever. The convalescent scores decreased/remained the same as acute sera in the other 35 subjects, which more likely indicating previous S. typhi infections. Using serially collected sera, it was determined that anti-Salmonella O9 IgM could be detected for a long period after illness.
Conclusion: Tubex® TF test should be conducted using paired acute- and convalescent-phase sera to reduce the chance of false positive result that may due to long-lasting anti-Salmonella O9 IgM.
The association of prostatic inflammation grade with prostate volume and Prostate-Specific Antigen (PSA) value in Benign Prostate Hyperplasia (BPH) patients at Wahidin Sudirohusodo Hospital, Makassar
Authors: Saleh Adriandy , Sahrir Syakri , Palinrungi Muhammad Asykar Ansharullah , Kholis Khoirul , Bakri Syarif , Miskad Upik Anderiani , Seweng Arifin 
Published: February 2022

Background: Prostate inflammation is commonly found in patients with benign prostate hyperplasia. On the histopathological examination, infiltration of the prostate gland's inflammatory cells was visible in chronic inflammation of the prostate. This study aims to determine prostate inflammation's association based on the histological examination with prostate volume and prostate-specific antigen (PSA) levels in benign prostate hyperplasia (BPH) patients.Methods: A cross-sectional study was enrolled among 50 subjects with benign prostate enlargement observed at Wahidin Sudirohusodo hospital and its affiliate Hospitals in Indonesia from April to September 2018. The patients' data, including age, prostate volume, PSA level, and histopathology, were collected. Statistical tests using Chi-square were performed (considered significant if P <0.05). Data were analyzed using SPSS version 17 for Windows.Results: Among 50 subjects, the age ranged from 51 to 85 years, with an average of 68.2 Â± 8.9 years, while the prostate volume average remained at 64.2 Â± 31.4 mm3.Â The average of the prostate-specific antigen (PSA) grade was 21.0 Â± 30.2 ng/ml. The statistical analysis showed the association of age with the degree of inflammation (P = 0.25), the relationship of the prostate volume of the degree of inflammation (P = 0.46) and the value of PSA (P = 0.74). Among the 50 subjects examined, 100% were inflamed. The highest grade of inflammation was a moderate degree by 19 cases (38%). There is no significant relationship between the degree of inflammation with prostate volume and PSA's value (p>0.05). Besides, there is no significant association between the degree of prostate inflammation with prostate volume and the value PSA levels (p>0.05).Conclusion: On the histopathological examination, inflammation was found in all research subjects with BPH, in which the highest degree of inflammation was at a moderate level.
Near point of convergence amongst school aged children with refractive errors in Bali
Authors: Aryawan I Ketut , Handayani Ariesanti Tri , Triningrat Anak Agung Mas Putrawati , Manuaba Ida Bagus Putra 
Published: February 2022

Background: Near Point of Convergence (NPC) is a nearest point where the image still properly fused and the patient do not experience double vision. However, there is still no study that evaluate the normative value of NPC in Indonesia. Therefore, the purpose of this study was to evaluate NPC break and recovery amongst school aged children with refractive error in Badung Regency, Bali.Methods: A cross-sectional study was conducted from July to September 2018. Data were collected prospectively from the examinations of school aged children in four elementary schools. Categorical data were described in frequency and percentage. The others were described in median. Kruskal Wallis test was used to statistically analyzed the data.Results: A total of 149 children were included in this study, which consisted of 56.4% women and 43.6% men. Most of the students were at 7years old age group (25.5%), while only minority who in the 12-years old age group (2%). Median NPC Break is 3,5 cm and 3,70 cm in male and female, respectively (p = 0,77). The median NPC break and recovery was greater in the 9 to 12 years old group compared to the other groups (p = 0.007 and p =0.00, respectively). Finally, hypermetropia had a greater NPC break and recovery than another groups (p = 0.05). Conclusion: There were significant differences between NPC break and recovery value according to the age group and underlying refractive error.
A profile of laparoscopic ureterolithotomy: four years initial experience at Persahabatan Hospital, Jakarta, Indonesia
Authors: Hafizar Hafizar , Agung Natanael P , Afriansyah Andika , Mirza Hendy 
Published: February 2022

Introduction: The introduction of laparoscopy in the field of urology has advanced surgery into a minimally invasive era, achieving better perioperative outcomes and lower incidence of complications. This study reports on the profile of laparoscopic ureterolithotomy performed in Persahabatan Hospital, Jakarta.Method: This retrospective study examined laparoscopic procedures done during the years 2016-2019. Demographic characteristics, surgical duration, length of stay, perioperative parameters, and antibiotics prescribed were recorded.Result: A total of 30 cases were reported. The gender ratio was 2:1 (male to female), with a mean age of 54.2 Â± 9.9. Twenty-two (73.3%) had proximal ureteric stone. Surgical duration and length of stay had means of 197.4 Â± 46.1 minutes and 3.6 Â± 1.1 days, respectively. The mean blood loss, preoperative and postoperative hematocrit was 40.5 Â± 27.8 mL, 36.14% Â± 5.73 and 35.76% Â± 5.71, respectively. Mean preoperative and postoperative hemoglobin was 12.27 g/dL Â± 1.84Â and 12.12 g/dL Â± 1.89, respectively. The mean postoperative pain VAS score was 2.1 Â± 0.8. The most prescribed antibiotics for the procedure were cefoperazone (53.33%).Conclusion: Considerably short duration of operations and hospital stay comparable with other study findings were reported. This study can be applied as baseline data for further research.
The voiding pattern of aterm neonates
Authors: Ginting Jeremy Thompson , Sigumonrong Yacobda 
Published: February 2022

Introduction: The concept of voiding patterns in neonates had not been completely understood. The voiding pattern in neonates was physiologically different from that in older children. The brain's development affects voiding patterns in frequency, bladder volume, and post-void residual bladder volume, as the child keeps growing. This study aims to understand the physiological neonates' voiding system in Indonesian newborns.Materials and methods: We evaluate ten normal-born and 12 perinatology-hospitalized aterm neonates without anatomical or physiological urologic abnormalities at RSUP Haji Adam Malik from October to November 2019. We used an observational study, assessing the voiding physiology in newborns, including voiding frequency and urine volume. Infants with a history of urinary tract infection or present bacteriuria confirmed by urine culture were excluded. Voiding volume, frequency, bladder capacity, and residual volume were measured. Results: We collected a total of 22 patients, with 12 patients were perinatology-hospitalized and ten patients were healthy neonates with ten subjects were male, and 12 subjects were female. There was no correlation between voiding frequency and total voiding volume with perinatology-hospitalized, healthy neonates, and sex. (p>0.05). Independent T-test was performed with a p-value for volume, frequency, bladder capacity, and residual volume of 0.225, 0.112, 0.031, and 0.663. We got a significant difference in bladder capacity between healthy neonates and perinatology-hospitalized. No significant differences were noted in other variables. Pearson correlation analysis was performed to determine the correlation between total voiding volume and age of gestation, body weight, length, head circumference, abdominal circumference, and chest circumference. The correlation coefficients were 0.772, 0.869, 0.623, 0.698, 0.079, 0.523 in order, with significant p-value in the age of gestation, body weight, length, head circumference, and chest circumference. There were correlations between total voiding volume and age of gestation, body weight, length, head circumference, and chest circumference.Â Conclusion: In conclusion, we found there was a significant difference in bladder capacity between healthy neonates and perinatology-hospitalized.
The relationship of blood group, blood components, and the age of patients with the degree of transfusion reaction at Dr. Wahidin Sudirohusodo, Makassar, Indonesia
Authors: Sembai Helena , Samad Raehana , Muhiddin Rachmawati Adiputri , Arif Mansyur 
Published: February 2022

Background: Transfusion is an additional therapy in the case of hematology and non-hematology. However, it can be detrimental due to its side effects ranging from mild to severe reactions. This study aimed to determine the relationship of blood types, blood components, and the age of patients with the degree of transfusion reaction. Methods: A retrospective study with secondary data of the patients experiencing transfusion reactions was conducted from January 2017 to December 2019. The population included all patients receiving a transfusion of blood products. The sample met the inclusion criteria, such as the medical records of patients who experienced transfusion reactions during and after the transfusion. The exclusion criteria were cryoprecipitate blood components. Data were analyzed using SPSS version 20 for Windows. Results: Among 228 subjects, there were a higher number (52.60%) of females than males (47.40%). The majority of patients ranged within 40-59 years old (52.70%). Most blood types were O (53.00%), while the dominant blood component was PRC (packed red cell) (50.30%). There was no significant relationship between blood types, blood components, and the age of patients with the degree of transfusion reaction (p>0.05).Conclusion: There was no significant relationship between blood types, blood components, and the age of patients with the degree of transfusion reaction.
Tuberculosis cases comparison in developed country (Australia) and developing country (Indonesia): a comprehensive review from clinical, epidemiological, and microbiological aspects
Authors: Harta Wedari Ni Luh Putu , Pranata I Wayan Adi , Budayanti Ni Nyoman Sri , Sukrama I Dewa Made 
Published: February 2022

Background: Tuberculosis (TB) is one of most crucial public health issues around the world. TB is an entity of a complex disease with the socio-economic aspect that has very strong correlation in regard to combat this disease. Migration from developing country to developed country inevitably possesses big influence on global epidemiologic of TB. In Australia, TB still becomes the main threat not only in native population but also regarding the migrant movement into Australia. Indonesia is one of among the TB endemic countries with high TB cases, in which not merely due to its high TB prevalence and incidence but also influenced by very high and dense population.Aim: This literature aims to review the clinical, epidemiological, and microbiological aspects of tuberculosis as a comparison between developed country (Australia) and developing country (Indonesia).Conclusion: Tuberculosis cases in Australia remains low compared to Indonesia, however, the close proximity to adjacent developing countries with high endemic of TB contributes significantly to increase number of TB in Australia. Tuberculosis can be cured by following the treatment guidelines with proper monitoring. Moreover, the collaboration between public and private sector along with active collaboration from the family or people surrounding the patients is required to eliminate TB disease.