bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ventilation management and outcomes in out-of-hospital cardiac arrest: a protocol for a preplanned secondary analysis of the TTM2 trial
Authors: Robba Chiara , Nielsen Niklas , Dankiewicz Josef , Badenes Rafael , Battaglini Denise , Ball Lorenzo , Brunetti Iole , Pedro David Wendel-Garcia , Young Paul , Eastwood Glenn , Chew Michelle S , Jakobsen Janus , Unden Johan , Thomas Matthew , Joannidis Michael , Nichol Alistair , Lundin Andreas , Hollenberg Jacob , Lilja Gisela , Hammond Naomi E , Saxena Manoj , Martin Annborn , Solar Miroslav , Taccone Fabio Silvio , Friberg Hans A , Pelosi Paolo 
Published: March 2022

IntroductionMechanical ventilation is a fundamental component in the management of patients post cardiac arrest. However, the ventilator settings and the gas-exchange targets used after cardiac arrest may not be optimal to minimise post-anoxic secondary brain injury. Therefore, questions remain regarding the best ventilator management in such patients.Methods and analysisThis is a preplanned analysis of the international randomised controlled trial, targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (OHCA)–target temperature management 2 (TTM2). The primary objective is to describe ventilatory settings and gas exchange in patients who required invasive mechanical ventilation and included in the TTM2 trial. Secondary objectives include evaluating the association of ventilator settings and gas-exchange values with 6 months mortality and neurological outcome. Adult patients after an OHCA who were included in the TTM2 trial and who received invasive mechanical ventilation will be eligible for this analysis. Data collected in the TTM2 trial that will be analysed include patients’ prehospital characteristics, clinical examination, ventilator settings and arterial blood gases recorded at hospital and intensive care unit (ICU) admission and daily during ICU stay.Ethics and disseminationThe TTM2 study has been approved by the regional ethics committee at Lund University and by all relevant ethics boards in participating countries. No further ethical committee approval is required for this secondary analysis. Data will be disseminated to the scientific community by abstracts and by original articles submitted to peer-reviewed journals.Trial registration numberNCT02908308.
Efficacy and predictive biomarkers of immunotherapy in Epstein-Barr virus-associated gastric cancer
Authors: Bai Yuezong , Xie Tong , Wang Zhenghang , Tong Shuang , Zhao Xiaochen , Zhao Feilong , Cai Jinping , Wei Xiaofan , Peng Zhi , Shen Lin 
Published: March 2022

BackgroundEpstein-Barr virus (EBV)-associated gastric cancer (GC) (EBVaGC) is a distinct molecular subtype of GC with a favorable prognosis. However, the exact effects and potential mechanisms of EBV infection on immune checkpoint blockade (ICB) efficacy in GC remain to be clarified. Additionally, EBV-encoded RNA (EBER) in situ hybridization (ISH), the traditional method to detect EBV, could cause false-positive/false-negative results and not allow for characterizing other molecular biomarkers recommended by standard treatment guidelines for GC. Herein, we sought to investigate the efficacy and potential biomarkers of ICB in EBVaGC identified by next-generation sequencing (NGS).DesignAn NGS-based algorithm for detecting EBV was established and validated using two independent GC cohorts (124 in the training cohort and 76 in the validation cohort). The value of EBV infection for predicting ICB efficacy was evaluated among 95 patients with advanced or metastatic GC receiving ICB. The molecular predictive biomarkers for ICB efficacy were identified to improve the prediction accuracy of ICB efficacy in 22 patients with EBVaGC.ResultsCompared with orthogonal assay (EBER-ISH) results, the NGS-based algorithm achieved high performance with a sensitivity of 95.7% (22/23) and a specificity of 100% (53/53). EBV status was identified as an independent predictive factor for overall survival and progression-free survival in patients with DNA mismatch repair proficient (pMMR) GC following ICB. Moreover, the patients with EBV+/pMMR and EBV−/MMR deficient (dMMR) had comparable and favorable survival following ICB. Twenty-two patients with EBV+/pMMR achieved an objective response rate of 54.5% (12/22) on immunotherapy. Patients with EBVaGC with a high cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) level were less responsive to anti-programmed death-1/ligand 1 (PD-1/L1) monotherapy, and the combination of anti-CTLA-4 plus anti-PD-1/L1 checkpoint blockade benefited patients with EBVaGC more than anti-PD-1/L1 monotherapy with a trend close to significance (p=0.074). There were nearly significant differences in tumor mutational burden (TMB) level andSMARCA4mutation frequency between the ICB response and non-response group.ConclusionsWe developed an efficient NGS-based EBV detection strategy, and this strategy-identified EBV infection was as effective as dMMR in predicting ICB efficacy in GC. Additionally, we identified CTLA-4, TMB, andSMARCA4mutation as potential predictive biomarkers of ICB efficacy in EBVaGC, which might better inform ICB treatment for EBVaGC.
Geriatric trauma prognosis trends over 10 years: analysis of a nationwide trauma registry
Authors: Nishimura Takeshi , Naito Hiromichi , Nakao Atsunori , Nakayama Shinichi 
Published: March 2022

PurposeWith Japan’s population rapidly skewing toward aging, the number of geriatric trauma patients is expected to increase. Since we need to continue to improve the quality of geriatric trauma patient care, this study aimed to evaluate in-hospital mortality trends among geriatric trauma patients in Japan over a recent 10-year period.MethodsThis was a retrospective cohort study of data from a Japanese nationwide trauma registry (the Japan National Trauma Data Bank) on patients admitted between January 1, 2008 and December 31, 2017. Geriatric patients were defined as those 65 years old and older. The primary outcome was to clarify in-hospital mortality trends and changes over these 10 years.ResultsWe identified 265 268 eligible trauma patients. Excluding those under 65 years old and those with inadequate or unknown age data, missing prognosis, out-of-hospital cardiac arrest, and burns, 107 766 patients were enrolled in this study. The total trauma patient in-hospital mortality trend was evaluated using the Cochran-Armitage test and showed a significant decrease (p<0.001). Although severe trauma patients (Injury Severity Score (ISS) ≥16) showed a significant decreasing trend (p<0.001) over time (from 26.1% to 14.5%), less-severe trauma patients (ISS <16) did not (p=0.41) (from 2.7% to 2.1%). Mixed logistic regression analysis showed that the number of year patients stayed in the hospital was significantly associated with mortality.ConclusionsWhile recognizing the limitations of the current analysis, our data demonstrated that prognoses for severe trauma patients over 65 years old improved dramatically over these 10 years, especially in those with severe trauma.Level of evidenceⅢ—retrospective cohort study.
Analysis and classification of privacy-sensitive content in social media posts
Authors: Bioglio Livio , Pensa Ruggero G. 
Published: March 2022

AbstractUser-generated contents often contain private information, even when they are shared publicly on social media and on the web in general. Although many filtering and natural language approaches for automatically detecting obscenities or hate speech have been proposed, determining whether a shared post contains sensitive information is still an open issue. The problem has been addressed by assuming, for instance, that sensitive contents are published anonymously, on anonymous social media platforms or with more restrictive privacy settings, but these assumptions are far from being realistic, since the authors of posts often underestimate or overlook their actual exposure to privacy risks. Hence, in this paper, we address the problem of content sensitivity analysis directly, by presenting and characterizing a new annotated corpus with around ten thousand posts, each one annotated as sensitive or non-sensitive by a pool of experts. We characterize our data with respect to the closely-related problem of self-disclosure, pointing out the main differences between the two tasks. We also present the results of several deep neural network models that outperform previous naive attempts of classifying social media posts according to their sensitivity, and show that state-of-the-art approaches based on anonymity and lexical analysis do not work in realistic application scenarios.
COMPARATIVE EVALUATION OF EFFICACY OF PERCUTANEOUS INTRADISCAL RADIOFREQUENCY ABLATION AND PLATELET RICH PLASMA INJECTION FOR DISCOGENIC LOW BACK PAIN: A PROSPECTIVE RANDOMIZED TRIAL
Authors: Goyal Titiksha , Paswan Anil Kumar , Jain Dhruv , Verma Nimisha , Dubey Rajeev Kumar 
Published: March 2022

Background: Discogenic pain is a common, yet underdiagnosed cause of low backache, for which a wide array of radiofrequency (RF) ablative techniques and regenerative therapies have been tried with variable results. The objective of the study was to compare pain relief and improvement in function between percutaneous intradiscal RF ablation and platelet-rich plasma (PRP) injection for the treatment of discogenic low backache. Methods: This double-blind, randomized, parallel-group interventional study was carried out in patients with chronic lumbar discogenic pain. Twenty-four patients each in percutaneous intradiscal radiofrequency (PIRF) ablation (Group R) and PRP injection (Group P) groups were analyzed. Numeric Rating Scale (NRS) and Oswestry Disability Index (ODI) were calculated before the procedure, and at 3 and 6 months after the procedure. Results: At 3 months, NRS score was significantly less in group R compared to group P ([Formula: see text]). However at 6 months, there was no statistically significant difference between NRS and ODI of both groups ([Formula: see text] and 0.369, respectively). Both NRS and ODI decreased significantly over 6 months within each group. Conclusion: No significant difference in efficacy of PIRF ablation and intradiscal PRP injection was observed at 6 months follow-up, although there was a significant improvement in pain and disability with both the procedures.
On the singular Weinstein conjecture and the existence of escape orbits for b-Beltrami fields
Authors: Miranda Eva , Oms Cédric , Peralta-Salas Daniel 
Published: March 2022

Motivated by Poincaré’s orbits going to infinity in the (restricted) three-body problem [see H. Poincaré, Les Méthodes Nouvelles de la Mécanique Céleste, Vol. 3 (Gauthier-Villars, 1899) and A. Chenciner, Poincaré and the three-body problem, in Henri Poincaré, 1912–2012 (Birkhäuser, Basel, 2015), pp. 51–149], we investigate the generic existence of heteroclinic-like orbits in a neighborhood of the critical set of a [Formula: see text]-contact form. This is done by using a singular counterpart [R. Cardona, E. Miranda and D. Peralta-Salas, Euler flows and singular geometric structures, Philos. Trans. R. Soc. A 377(2158) (2019) 20190034] of Etnyre–Ghrist’s contact/Beltrami correspondence [J. Etnyre and R. Ghrist, Contact topology and hydrodynamics: I. Beltrami fields and the Seifert conjecture, Nonlinearity 13(2) (2000) 441–458], and genericity results concerning eigenfunctions of the Laplacian established by Uhlenbeck [Generic properties of eigenfunctions, Amer. J. Math. 98(4) (1976) 1059–1078]. Specifically, we analyze the [Formula: see text]-Beltrami vector fields on [Formula: see text]-manifolds of dimension [Formula: see text] and prove that for a generic asymptotically exact [Formula: see text]-metric they exhibit escape orbits. We also show that a generic asymptotically symmetric [Formula: see text]-Beltrami vector field on an asymptotically flat [Formula: see text]-manifold has a generalized singular periodic orbit and at least four escape orbits. Generalized singular periodic orbits are trajectories of the vector field whose [Formula: see text]- and [Formula: see text]-limit sets intersect the critical surface. These results are a first step towards proving the singular Weinstein conjecture.
Global Oral Anticoagulation Use Varies by Region in Patients With Recent Diagnosis of Atrial Fibrillation: The GLORIA‐AF Phase III Registry
Authors: Bayer Valentina , Kotalczyk Agnieszka , Kea Bory , Teutsch Christine , Larsen Peter , Button Dana , Huisman Menno V. , Lip Gregory Y. H. , Olshansky Brian 
Published: March 2022

Background
Effective stroke prevention with oral anticoagulants (OAC) is recommended for some patients with atrial fibrillation (AF). We aimed to describe OAC use by geographical region and type of site in patients with recent‐onset AF enrolled in a large global registry.

Methods and Results
Eligible participants were recruited into GLORIA‐AF (Global Registry on Long‐Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation), a prospective observational cohort study from 2014 to 2016 in 4 international regions: North America, Europe, Asia, and Latin America. Cumulative incidence functions were generated for direct OACs (DOAC), vitamin K antagonists, and antiplatelet drugs considering competing risks, stratified by region and type of site. Time‐to‐treatment initiation after AF diagnosis was analyzed with Fine‐Gray subdistribution hazard models. A total of 21 237 patients eligible for analysis were identified. By 30 days after AF diagnosis, 40%, 16%, and 8.6% of patients had DOAC, vitamin K antagonists, and antiplatelet drugs initiated, respectively. Earlier initiation of DOACs was observed in Europe, with Asia and Latin America having lower hazard rates of DOAC time‐to‐treatment initiation than Europe (hazard ratio [HR], 0.66; 95% CI, 0.62–0.70 and HR, 0.79; 95% CI, 0.73–0.85, respectively). DOAC initiation was highest in community hospitals, vitamin K antagonists in outpatient health care centers/anticoagulation clinics, and antiplatelet drugs in primary care clinics.

Conclusions
Important geographic variability exists with the use of OACs for patients with AF. Differences in the time‐to‐treatment initiation of OAC by type of site suggests suboptimal implementation of guideline recommendations and could result in less benefit and more harm. Optimizing OAC use for patients with AF may improve outcomes and reduce health care costs.

Registration

URL:
http://www.clinicaltrials.gov
; Unique identifiers: NCT01468701, NCT01671007.
Meloidogyne-SP4 effector gene silencing reduces reproduction of root-knot nematodes in rice (Oryza sativa)
Authors: Nguyê˜n Phong V. , Biện Thanh LT. , Tôn Linh B. , Lê Ðôn Ð. , Wright M. Kathryn , Mantelin Sophie , Petitot Anne-Sophie , Fernandez Diana , Bellafiore Stéphane 
Published: March 2022

Summary
The root-knot nematodes (RKN) Meloidogyne graminicola and M. incognita are responsible for rice yield losses worldwide, particularly in Asia and Africa. Previous studies demonstrated that nematode-secreted proteins are crucial for root invasion and establishment in the host. We present some characteristics of a pioneer effector, M. incognita-secreted protein 4 (Mi-SP4), which is conserved in RKN and required for infection in compatible rice-RKN interactions. In situ hybridisation assays revealed Mi-SP4 expression in the dorsal pharyngeal gland of M. incognita second-stage juveniles (J2). Meloidogyne-SP4 transcripts strongly accumulated in pre-parasitic J2 and decreased in later parasitic stages of M. incognita and M. graminicola. Transient expression of the nematode effector gene in Nicotiana benthamiana leaves and onion cells indicated that GFP-tagged Mi-SP4 was present in the cytoplasm and accumulated in the nucleus of the plant cells. In vitro RNA interference (RNAi) gene silencing, obtained by soaking J2 with small-interfering (si)RNA si4-1, decreased Mi -SP4 expression in J2 by 35% and significantly reduced M. incognita reproduction in rice by at least 30%. Similarly, host-mediated gene silencing of the nematode SP4 effector candidate gene in transgenic rice plants significantly reduced M. graminicola reproduction by 26% to 47%. The data obtained demonstrate that Mi -SP4 is a pioneer virulence effector, which plays an essential role in both M. incognita and M. graminicola pathogenicity on rice.
Christianity and Shona Religion and Ecology
Authors: Beyers Jaco , Muza Kudakwashe 
Published: March 2022

Abstract
The biggest single threat to ecology and biodiversity is human-induced climate change. This study assesses ethics and attitudes in an African context for coping with climate change. This assessment takes place within an ethical-practical framework functioning within the mutuality model of interreligious dialogue. Christianity and Shona religion are brought into dialogue with one another to create a conversation on how to deal with ecology. As the main source of livelihood in Zimbabwe and the whole of Africa, agriculture has been affected by climatic changes. Disease outbreaks, floods, and droughts are on the rise since the world is experiencing severe temperature rise. In addressing the ecological crisis religious considerations must be taken into account. The pivotal role of religion in issues of climate change and environmental conservation hinges on religious ethics and religion’s ability to inspire its adherents to have environmentally friendly attitudes. Christianity and Shona religion can collaborate on addressing ecological problems since they have shared sets of ethics.
Prayer Camps, Mental Health, and Human Rights Concerns in Ghana
Authors: Benyah Francis 
Published: March 2022

Abstract
This article discusses the role that Ghana’s prayer camps provide in mental health care and the human rights concerns that are expressed. The article argues for the recognition of both state and nonstate actors in dealing with the problem of mental illness and its related human rights concerns. The article maintains that the mere existence of mental health legislation to protect the rights of mental health patients is not enough if it fails to recognise the religious dimensions – the beliefs, faith, or transcendental orientation – of the people who are the target object of such legislation. The article recommends to policy makers, academics, clinicians, and international organisations whose work focuses on mental health, ways in which religious views on mental illness can be harmonised to support modern projects such as human rights aimed at transforming the lives of people.
Media, Gender, and Religion in the Twenty-First Century
Authors: Gbadegesin Enoch Olujide , Wale-Olaitan Kemi 
Published: March 2022

Abstract
This paper asserts that since the Nigerian media is patriarchal, they inexorably present images that give the impression that men have a superior knowledge of God than women. This idea is incidentally reechoing in contemporary Nigerian Christian practices, especially in the age of the new media. The paper examines gender, religion, and media from historical perspectives; analyses the theoretical framework at the root of the construction of the female gender and their representation in religion; and lastly, presents selected examples from day-to-day empirical evidence from Christian organizations in the Nigerian media space with the aim of deconstructing the public image of Christian women in the Nigerian public square. It thus aims to reconstruct the public image of women in religion via the media, showing the importance of equal gender representation. The narrative concerning reconstruction is deeply contextual, analytical, rigorous, and interdisciplinary.
Sulle tracce del Galeno di Teodoro Gaza
Authors: Orlandi Luigi 
Published: March 2022

Abstract
This paper aims to shed light on the history of a book mentioned in the will of Theodoros Gazes, which has not been identified so far. It is a manuscript of Galen’s Methodus medendi. A combined palaeographic, philological, codicological and prosopographic analysis of some extant witnesses to the text leads to a tentative identification of the book belonged to Gazes, providing insights into the transmission of Galen’s work in the frame of the Italian Humanism.
Brokers and Translators
Authors: Lloydd Marnie 
Published: March 2022

Abstract
Through ethnographic observations from international humanitarian work and interviews with humanitarian professionals, Joe Cropp’s The Humanitarian Fix: Navigating Civilian Protection in Contemporary Wars engagingly describes the daily practice of humanitarian negotiation and persuasion. The book illustrates how the international humanitarian has morphed from the more classical neutral intermediary to emerge as a broker and translator with a toolbox of more official and less official reframings of international law and policy to grapple with local problems and persuade different actors. In this review essay, I highlight the hidden insight for international lawyers in Cropp’s book regarding questions of universality and pluralism in international humanitarian law and the double-bind practitioners face: while these practices of translation look like an openness to pluralism in humanitarian law, within the current international framework, any translation by necessity re-emphasises how these reframings are not the law, and ultimately work as techniques to reinforce the authority and claimed universality of the central system.
Uṣūl al-fiqh et philosophie : état des lieux
Authors: Bou Akl Ziad 
Published: March 2022

Résumé
Ce texte présente un état des lieux de la recherche moderne sur les uṣūl al-fiqh, en s’attachant notamment à en montrer les liens avec la philosophie, considérée dans un premier temps au sens strict et historique de tradition hellénistique autonome pratiquée par les falāsifa de l’époque médiévale, et dans un second temps, en un sens plus large qui englobe toute réflexion à portée universelle que renferment les traités de uṣūl al-fiqh.
The Legacy of Willem Beurs ‒ Bridging the Gap between Art and Material Perception
Authors: Di Cicco Francesca 
Published: March 2022

Abstract
Dutch Golden Age painters could convincingly depict all sorts of materials. How did they do it and how do we perceive them as such, are questions that only recently have started to be addressed by art historians and vision scientists, respectively. This paper aims to discuss how a booklet of pictorial recipes written by the Dutch painter Willem Beurs in 1692 constitutes an index of key image features for material depiction and perception. Beurs’ recipes connect different materials according to their shared visual features, and offer the profiles, i.e., the optimal combinations, of these features to render a wide range of materials. By combining representation and perception, the knowledge of painters about the depiction of materials can help to understand the mechanisms of the visual system for material perception, and these in turn can explain the pictorial features that make the pictorial representation of materials so convincing.