bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pseudocellulitis in the Setting of Pemetrexed Treatment for Non‐Small Cell Lung Cancer
Authors: Nguyen Cassidy M. , Robertson Jake C. , Cardenas Adam , Martinez Edgar , Keeling Brett H. , Nguyen Khang D. 
Published: January 2025

ABSTRACTPemetrexed is a chemotherapeutic, antimetabolite agent that has been used in oncology to treat diseases such as metastatic non‐small cell lung cancer and unresectable malignant pleural mesothelioma. Pemetrexed use may result in pseudocellulitis, which presents as poorly demarcated patches or plaques with erythema, edema, warmth, and tenderness. These lesions can present unilaterally or bilaterally on the lower extremities. The histologic appearance includes vacuolar interface dermatitis, squamous metaplasia of eccrine coils and ducts, sparse mixed neutrophilic and lymphocytic interstitial inflammatory infiltrate, and widened subcutaneous fibrous septa with cystic fat degeneration. We present the case of a 58‐year‐old woman with non‐small cell lung cancer and pemetrexed‐induced pseudocellulitis with distinctive histological features. The clinical appearance of patients with this hypersensitivity condition may mimic cellulitis, emphasizing the importance of increased awareness and consideration of pseudocellulitis in the differential diagnosis of patients on chemotherapy to avoid unnecessary hospitalization and treatment.
Histopathologic Features of Acral Skin Biopsies in Dermatomyositis Patients and Comparison to Histopathologic Features in Non‐Acral Biopsies
Authors: Cassard Lydia , Ali Firdous , Flatley Elizabeth M. , Fernandez Anthony Patrick 
Published: January 2025

ABSTRACTBackgroundAcral lesions may represent the best/only skin lesions to biopsy in patients suspected to have dermatomyositis (DM). However, histopathologic features of acral DM skin lesions are poorly characterized.MethodsWe reviewed 50 acral biopsies from 46 DM patients and assessed numerous histopathologic features. The majority of biopsies (42/50; 84%) were sampled from either Gottron papules or signs. We compared histopathologic features in acral biopsies to those in 197 non‐acral DM skin biopsies. We also compared histopathologic features in acral biopsies based on the presence of various clinical features.ResultsInterface dermatitis, dyskeratotic keratinocytes, and superficial perivascular inflammation were common in DM acral biopsies. However, the absence of > 1 hallmark histopathologic feature (interface dermatitis, dyskeratosis, dermal mucin) was relatively common (56%). The presence of all three hallmark histopathologic features was significantly more likely in non‐acral compared with acral DM biopsies (68% vs. 44%; p = 0.0021). The hallmark histopathologic feature most commonly lacking in acral compared with non‐acral biopsies was increased dermal mucin. Histopathologic features in acral biopsies did not significantly differ based on acral location, DM subtype, therapeutic regimen, or myositis‐associated/myositis‐specific antibody status.ConclusionsPathologists should recognize that acral biopsies in DM patients may lack hallmark histopathologic features commonly seen in biopsies from non‐acral locations.
Molecular Delimitation of Evolutionary Significant Units Reveals Hidden Geographic Drivers of Extinction Risk Within Island Arthropods
Authors: Jiménez‐García Eduardo , Suárez Daniel , Andújar Carmelo , López Heriberto , Emerson Brent C. 
Published: January 2025

ABSTRACTAimGlobally, arthropod biodiversity is under threat, with increased risk of species‐level extinctions, and this threat is particularly acute on oceanic islands. A fundamental first step towards understanding extinction risk is to understand genetic connectivity among the constituent populations of a species. Our aim is to develop and implement a protocol to characterise genetic connectivity among island populations within arthropod species to reveal otherwise hidden range size drivers of extinction.LocationCanary Islands, Spain.MethodsWe implement a protocol based on mtDNA sequence data for the delimitation of evolutionary significant units (ESUs) to evaluate extinction risk among species of beetle and spider distributed across multiple islands.ResultsOur results reveal that more than half of the species analysed are comprised of two or more ESUs. We also find that low dispersal ability was a significant predictor of ESUs within species of Coleoptera, but with no significant difference for Araneae.Main ConclusionsMost ESUs are consistent with early stage differentiation or incipient speciation, with some exceeding a conservative interspecific threshold, thus indicative of cryptic species. We suggest that extending our approach with the integration of other species‐level traits may provide for a more refined predictive framework for understanding extinction risks across island arthropod species.
Evaluation of Long‐Term Clinical and Radiographic Prognosis of Avulsed Teeth: A Retrospective Study
Authors: Ozturk Sheikholaemeh Nilay , Sengul Fatih 
Published: January 2025

ABSTRACTBackground/AimAvulsion injuries have an uncertain prognosis. This study aims to evaluate periodontal ligament healing patterns and factors affecting the survival of replanted avulsed teeth.Materials and MethodsIn this retrospective study, data from 204 avulsed teeth in 143 children (mean age: 9.6 ± 2 years) who sustained avulsion injuries were reviewed. Primary teeth, non‐replanted permanent teeth, and cases with follow‐up shorter than 60 days were excluded. Data analysis included 60 replanted permanent teeth from 41 patients (18 girls and 23 boys), with a follow‐up period ranging from 2 to 147 months. Collected data covered age, gender, extra‐alveolar storage time, root development stage, and periodontal ligament healing patterns. Statistical analysis was performed on the data.ResultsAvulsion injuries predominantly occurred during outdoor activities (n = 22, 59.5%), followed by school (n = 10, 27%) and home (n = 5, 13.5%). The main causes were falls (n = 20, 50%), bicycle accidents (n = 6, 15%), sports injuries (n = 5, 12.5%), traffic accidents (n = 2, 5%), and violence (n = 1, 2.5%). Among replanted teeth, 51.7% were immature. Treatments included root canal therapy (n = 30, 50%), apexification (n = 12, 20%), and regeneration (n = 2, 3.3%), while 16 teeth received no treatment. Inflammatory resorption was not observed in teeth replanted within 1 h of injury (8.4%). Functional healing/ankylosis was observed in 14 (23.3%) of the replanted teeth, replacement resorption in 40 (66.7%), and inflammatory resorption in 6 (10%). Replacement resorption affected 66.7% of the replanted teeth, with 62.5% lost over time. Functional healing/ankylosis was more common in mature teeth, while inflammatory resorption was higher in immature teeth. According to Kaplan–Meier estimated survival curves, the survival rate during the 5‐year observation period was 47.5%. Survival times were longer in boys and in mature teeth (p < 0.05).ConclusionsGender and root development stages were observed to significantly impact the prognosis of replanted avulsed teeth.
A Novel Team‐Based Approach to Oral Diagnosis Education: Case of the Week
Authors: Al‐Rawi Natheer H. , Al Kawas Sausan , Mohammed Marwan M. , Taha Wael , Hamdan Ahmad M. 
Published: January 2025

ABSTRACTBackgroundTraditional oral diagnosis education often relies on passive lectures and individual case assessments. Team‐based learning (TBL) offers an interactive alternative, but implementation challenges can exist. The ‘Case of the Week (COW)’ method presents a potentially modified TBL approach for oral diagnosis education.ObjectivesThis study aims to evaluate the effectiveness of the COW method in enhancing student engagement for acquiring knowledge and diagnostic skills in oral diagnosis. Additionally, we seek to explore its impact on promoting teamwork and collaboration among students, as well as assessing overall student satisfaction with this learning approach.MethodsStudents were invited to participate in a post‐COW questionnaire. This questionnaire utilised a five‐point Likert scale to gather student ratings across five distinct domains: Knowledge acquisition, Learning environment, Student preparedness for assessment, Student preparedness as a clinician and overall student experience with the COW activity.ResultsThe response rate was 75%, with 140 responses gathered from two groups of 70 students in each. The majority of students found COW activity valuable for acquiring knowledge (intellectual stimulation, critical thinking), teamwork and presentation skills and creating a comfortable learning environment. Furthermore, students indicated that the COW was more effective than traditional lectures in preparing them for future clinical practice. Furthermore, students reported that the COW motivated independent learning, facilitated research skills development and enhanced communication abilities.ConclusionThe COW method has the potential to be an effective and engaging modified TBL approach for oral diagnosis education. By fostering knowledge acquisition, promoting teamwork and enhancing student satisfaction, it offers a dynamic and impactful learning experience.
Do we Need to Perform Bone Marrow Examination in all Subjects Suspected of MDS? Evaluation and Validation of Non‐Invasive (Web‐Based) Diagnostic Algorithm
Authors: Oster Howard S. , Polakow Ariel M. , Gat Roi , Goldschmidt Noa , Ben‐Ezra Jonathan , Mittelman Moshe 
Published: January 2025

ABSTRACTBackgroundBone marrow examination (BME) is the gold standard of diagnosing myelodysplastic syndromes (MDS). Problems: it is invasive, painful, causing possible bleeding, inaccurate (aspirate hemodilution), and subjective (inter‐observer interpretation discordance). We developed non‐invasive diagnostic tools: A logistic regression formula [LeukRes 2018], then a web algorithm using 10 variables (age, gender, Hb, MCV, WBC, ANC, monocytes, PLT, glucose, creatinine) to diagnose/exclude MDS [BldAdv 2021]. Here, we perform external validation of the model.MethodsFrom the TASMC BM registry (2019–22) we identified and compared the model performance between MDS patients and controls (> 50 year with unexplained anemia, not MDS), all BME diagnosed, and not used in model building.ResultsThe model was accurate and predicted MDS in 63% of 103 patients, and excluded (correctly) in 83% of 101 controls. It miss‐classified in 11%/7% respectively, and was indeterminate in 26%/10% respectively. The positive predictive value (PPV), NPV, sensitivity, and specificity (excluding the indeterminate group) were 90%, 88%, 86%, and 92%, respectively. Subgroup (Lower/higher risk, LR/HR) analysis results were similar.ConclusionsThe MDS diagnostic model was validated and can be used, mainly for MDS exclusion, especially in suspected LR‐MDS, avoiding BME in some patients. In the future incorporating peripheral blood genetics and morphometry can further improve the model.
The effect of epilepsy surgery on tonic–clonic seizures
Authors: Alcala‐Zermeno Juan Luis , Romozzi Marina , Sperling Michael R. 
Published: January 2025

AbstractObjectiveEpilepsy surgery outcomes tend to be judged by the percentage in seizure reduction without considering the effect on specific seizure types, particularly tonic–clonic seizures, which produce the greatest morbidity and mortality. We assess how often focal to bilateral tonic–clonic seizures (BTCS) stop and how often they appear de novo after epilepsy surgery.MethodsAnalysis of a prospectively maintained epilepsy surgery database between 1986 and 2022 that characterizes the burden of BTCS after resective epilepsy surgery. Patients were stratified according to presence or absence of preoperative BTCS and whether these were active (defined as ≥1 BTCS/year prior to surgery) or remote.ResultsA total of 804 patients were followed for a median of 7 years (interquartile range [IQR] = 3–13 years) after epilepsy surgery, most being temporal lobe resections (91%, 95% confidence interval [CI] = 89–93%). At last visit, 72% of patients (95% CI = 69–75%) were seizure‐free for 1 year or more. Of 521 patients with preoperative BTCS, 300 (58%, 95% CI = 53%–61%) no longer had them after surgery. BTCS recurred in 221 patients, but 128 of them (58%, 95% CI = 51%–64%) had no BTCS in the last year of follow‐up. Those patients who continued to experience BTCS after surgery had a median reduction of 92% in yearly BTCS frequency (IQR = 65%–98%, p < .001). Of 283 patients with no preoperative BTCS, 17 developed de novo BTCS (6%, 95% CI = 4%–9%), with a median of 2 BTCS during the entire follow‐up period. Forty‐seven percent (95% CI = 42%–53%) of patients without preoperative BTCS became seizure‐free after surgery, compared with 33% (95% CI = 29–37, p < .001) of patients with preoperative BTCS.SignificanceEpilepsy surgery markedly reduces or eliminates BTCS, which should have a potential positive impact on morbidity and mortality. This favors offering surgery even if the chance of seizure freedom is not high and calls for a new surgical outcome scale to factor in seizure severity reduction.
Mating May Enhance Rapid Formation of Stable Pair Bonds in the Monogamous California Mouse
Authors: Roy Robert , Hammerdahl Elsa , Sage Andrew , Becker Elizabeth A. 
Published: January 2025

ABSTRACTPair bonds are a hallmark of many monogamous species, yet in the monogamous California mouse (Peromyscus californicus) pair‐bond formation is poorly understood. While pair bonds are often assumed to be present after a week of cohabitation, when they actually form in this species is debated. To characterize pair bond latency in California mice, we conducted three‐chamber partner preference tests for both males and females following 1, 3, 5, or 7 days of cohabitation. Since copulation may contribute to pair‐bond formation, animals were paired when females were in estrus and were assessed continuously throughout the cohabitation period for copulatory behavior. We found evidence of pair bonds after 24 h of cohabitation for both sexes with no significant changes in partner preference behaviors across cohabitation periods. Focal animals spent more time in the partner's chamber, were more affiliative toward the partner than the stranger and displayed more aggressive behavior toward the stranger. Affiliative behaviors were consistent between the sexes, while males attacked the stranger more frequently and for longer durations than females. Pairs that copulated prior to partner‐preference testing spent more time in the partner's chamber and more time huddling, licking, and grooming their mate than those that did not copulate. We conclude that although copulation may not be necessary for pair‐bond formation, sexual receptivity at time of pairing is important for the development of these social relationships and that copulation may serve to enhance pair bonds in California mice.
Appropriateness of lumbar spine imaging in patients presenting to the emergency department with low back pain in a Western Australian tertiary hospital
Authors: Mau Aaron W. K. , Keen Helen I. , Hill Catherine L. , Buchbinder Rachelle 
Published: January 2025

AbstractBackgroundThe Australian Rheumatology Association identified the use of imaging in patients with low back pain without indication of serious pathology as a low‐value practice.AimsTo determine the appropriateness of diagnostic lumbar spine imaging requests in patients with low back pain presenting to a Western Australian hospital's emergency department.MethodsWe conducted a retrospective review of all adult patients (18 years and older) who presented with low back pain to the Fiona Stanley Hospital emergency department from 1 July 2020 to 31 December 2020. The appropriateness of the imaging requests was judged using the American College of Radiology's Appropriateness Criteria. The number and proportion of appropriate and inappropriate lumbar spine imaging requests were reported overall and by imaging modality together with reasons for the judgements.ResultsA total of 1459 patients were included. Three hundred eight patients (21.1%) received lumbar spine imaging requests, with 350 diagnostic imaging requests eligible for analysis. Two hundred eighty (80.0%) imaging requests were judged to be appropriate (194/253 (76.7%) plain radiographs, 57/66 (86.4%) computed tomography, 29/31 (93.5%) magnetic resonance imaging). The most common reasons for an appropriate imaging request were suspected vertebral fracture (n = 223, 79.6%), followed by malignancy (n = 26, 9.3%). Of the 70 inappropriate imaging requests, 62 (88.6%) requests occurred in the absence of alerting features and eight (11.4%) requests were the wrong choice of modality.ConclusionsFour in five lumbar spine imaging requests for investigating low back pain were appropriate. Of the inappropriate requests, the most common reason was the absence of alerting features, while a small number were the incorrect imaging modality.
Technological Competence in Formal Education Collaborative Maker Projects: An Epistemic Network Analysis
Authors: Niinimäki Niina , Sormunen Kati , Seitamaa‐Hakkarainen Pirita , Davies Sini , Kangas Kaiju 
Published: January 2025

ABSTRACTBackgroundImplementing maker education in schools is on the rise, fuelled by its potential to move formal education towards a creative, technology‐driven 21st century learning culture. In maker education, collaborative learning takes place through and around various digital and traditional technologies, which provide the means for students' creative activities. However, research is scarce on how maker education promotes students' technological competence and how students develop different features of that competence.ObjectivesThis study investigates the learning of technological competence in formal education collaborative maker projects focusing on designing and making electronic textiles (e‐textiles).MethodsThe data consisted of student teams' discourse from classroom video data, in which five 7th‐grade student teams (3–6 students/team, 13‐ to 14‐year‐olds) were engaged in designing and making e‐textiles. Their discourse was categorised into five technology dimensions—crafting, designing, engineering, programming, and documenting—and epistemic network analysis was used to model the co‐occurrences of the dimensions.Results and ConclusionsAll five technology dimensions were present in four of the five teams, but the learning outcomes—that is, the emphasis and connections of the dimensions—varied between the teams. Learning was promoted when technology was used as means for joint construction of knowledge objects but hindered when viewed only as tool for task execution. The results indicate that collaborative maker projects enable the learning of comprehensive technological competence including knowledge and skills related to both digital and traditional technologies. However, implementing a maker project in schools is insufficient to guarantee that all technology dimensions will be addressed.
Parental psychopathology before and after the child's diagnosis of a mental disorder: a population‐based matched cohort study
Authors: Chatwin Hannah , Holde Katrine , Wimberley Theresa , Dalsgaard Søren , Petersen Liselotte Vogdrup 
Published: January 2025

BackgroundMore research is needed to understand psychopathology among parents of children with mental disorders in the years before and after the child is diagnosed. Here, we estimated the risk of mental disorders and psychotropic medication use in parents of children with versus without mental disorders and the temporal associations between child and parental psychopathology.MethodsWe conducted a population‐based matched cohort study using Danish register data. The study population included child–parent pairs of all children diagnosed with a mental disorder of interest (attention‐deficit/hyperactivity disorder, autism spectrum disorder, intellectual disability, anxiety disorder, mood disorder, eating disorder, substance use disorder, and schizophrenia spectrum disorder) by 18 years of age during the period 1999–2014 and a matched reference population. Each child with a diagnosis was matched to 10 children of the same sex and birth year who had not been diagnosed with the mental disorder of interest. For all parents, we estimated the yearly incidence proportion of parental mental disorders and prescriptions for psychotropic medications 4 years before and after the child's diagnosis.ResultsWe observed a substantially increased risk of mental disorders and psychotropic medication use among parents of children with a mental disorder, compared to the reference population. On average, parents of children with a diagnosis had twice the odds of mood disorders, anxiety disorders, and prescriptions for anti‐depressants and anti‐psychotics. The incidence of mood and anxiety disorders peaked in the 1–2 years before and after the child's diagnosis. The incidence of parental prescriptions for psychotropic medications (particularly anti‐psychotics) peaked in the year the child was diagnosed and in the 3 years before the child's diagnosis for anti‐depressants and sleep medications.ConclusionsThis study demonstrates clear temporal associations between child and parental psychopathology, with parental psychopathology peaking in the years immediately before and after the child's diagnosis.
Book Translations From Chinese to English: The Center–Periphery Relationship in the World System of Book Translations
Authors: Wu Jing 
Published: January 2025

ABSTRACTBy collating and analyzing various datasets, this paper gives a statistical overview of the flow of Chinese to English book translations, analyzing the asymmetrical structure of the global flow of book translations and the positions of Chinese and English within it. It firstly portrays the asymmetries of China/Chinese and Anglo‐American countries/English in the international exchange of book translations and in the copyright trade, reviewing the center–periphery relationship between Chinese and English in the international book market. Based on UK national book statistics, it then illustrates the general picture of the production of Chinese books translated in English in the UK, analyzing the publishing trends from 1949 to 2020, Chinese translated books published in the UK, and publishers involved in translating from Chinese to English.