bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of comprehensive geriatric care on depressive symptoms, emergency department visits, re‐hospitalization and discharge to the same residence in older persons receiving hip‐fracture surgery: A meta‐analysis
Authors: Su Shu‐Fen , Lin Shu‐Ni 
Published: August 2022

AbstractAimThe aim of this study was to evaluate depressive symptoms, emergency department visits, re‐hospitalization and discharge to the same residence of comprehensive geriatric care in patients receiving hip‐fracture surgery.BackgroundHip fractures among older persons result in restricted activities of daily living, longer hospital stays, frequent emergency department visits and re‐presentation to hospital, which may increase depressive symptoms and death risk. The benefits of comprehensive geriatric care have not been determined.DesignA five‐step Cochrane collaboration meta‐analysis was used.Data SourcesRandomized controlled trials published from 1980 to 2020 in which comprehensive geriatric care was provided following hip‐fracture surgery were retrieved from the Cochrane Library, Clinical Key, Embase, MEDLINE, OVID and PubMed databases. Indicators were depressive symptoms, emergency department visits, re‐hospitalization and discharge to the same residence.Review MethodsThe Group Reading Assessment, Risk of Bias 2.0 tool, modified Jadad scale and Comprehensive Meta‐Analysis Version 3 software were used.ResultsOverall, 1291 patients from six randomised controlled trials were included. Comprehensive geriatric care improved depressive symptoms and lowered emergency department visits but did not improve re‐hospitalization rates or discharge to the same residence.ConclusionComprehensive geriatric care should include depression management and individualized care plans. Further depression‐related studies are required to verify their benefits.
European guideline (EuroGuiDerm) on atopic eczema: part I – systemic therapy
Authors: Wollenberg A. , Kinberger M. , Arents B. , Aszodi N. , Avila Valle G. , Barbarot S. , Bieber T. , Brough H.A. , Calzavara Pinton P. , Christen‐Zäch S. , Deleuran M. , Dittmann M. , Dressler C. , Fink‐Wagner A.H. , Fosse N. , Gáspár K. , Gerbens L. , Gieler U. , Girolomoni G. , Gregoriou S. , Mortz C.G. , Nast A. , Nygaard U. , Redding M. , Rehbinder E.M. , Ring J. , Rossi M. , Serra‐Baldrich E. , Simon D. , Szalai Z.Z. , Szepietowski J.C. , Torrelo A. , Werfel T. , Flohr C. 
Published: August 2022

AbstractThe evidence‐ and consensus‐based guideline on atopic eczema was developed in accordance with the EuroGuiDerm Guideline and Consensus Statement Development Manual. Four consensus conferences were held between December 2020 and July 2021. Twenty‐nine experts (including clinicians and patient representatives) from 12 European countries participated. This first part of the guideline includes general information on its scope and purpose, the health questions covered, target users and a methods section. It also provides guidance on which patients should be treated with systemic therapies, as well as recommendations and detailed information on each systemic drug. The systemic treatment options discussed in the guideline comprise conventional immunosuppressive drugs (azathioprine, ciclosporin, glucocorticosteroids, methotrexate and mycophenolate mofetil), biologics (dupilumab, lebrikizumab, nemolizumab, omalizumab and tralokinumab) and janus kinase inhibitors (abrocitinib, baricitinib and upadacitinib). Part two of the guideline will address avoidance of provocation factors, dietary interventions, immunotherapy, complementary medicine, educational interventions, occupational and psychodermatological aspects, patient perspective and considerations for paediatric, adolescent, pregnant and breastfeeding patients.
A review: Application and research progress of bioimpedance in meat quality inspection
Authors: Zhang Ziyi , Li Xinxing , Tian Jianjun , Chen Jing , Gao Ge 
Published: August 2022

AbstractBioimpedance is an effective analytical technique for electrochemical system, which has the advantages of rapid, nondestructive, inexpensive, and easy to implement, and has shown a wide application for food quality and safety assessment recently. The main objectives of this review are to review recent progress in the application of bioimpedance in the detection of various meat quality attributes, and conduct a classification review in accordance with detection indicators of meat products, including carcass composition (IMF, fat, water, etc.) and physicochemical properties (TVB‐N, pH, shear force, etc.). In addition, we describe the basic principle of bioimpedance and factors affecting the measurement of impedance. Finally, we discussed the challenges of bioimpedance technology applied to meat quality inspection. The measurement device should be further optimized to reduce the effects of electrode polarization and muscle anisotropy, while more effective equivalent circuit models and data processing methods should be investigated. And the integration of other technologies and the development of certain bio‐detection devices, as well as the point‐of‐need diagnostic devices, are expected to be future trends in impedance technology.
Medicare's annual wellness visit: 10 years of opportunities gained and lost
Authors: Coll Patrick P. , Batsis John A. , Friedman Susan M. , Flaherty Ellen 
Published: August 2022

AbstractMedicare annual wellness visits (AWV) were initiated 10 years ago. Though AWVs emphasize on disease prevention and health promotion for older adults was a huge step forward, the current “one size fits all” approach does not adequately meet the wellness needs of a diverse population of older adults. Current AWVs do not sufficiently take into consideration the medical, psychological, functional, racial, cultural and socio‐economic diversity of older adults. Updated AWVs should be tailored to meet the needs and priorities of older adults receiving them. Several geriatrics approaches to care, including geriatrics Glidepaths and the 4Ms of an Age‐Friendly Health System, could help develop and guide a more patient‐specific geriatrics focused approach to AWVs. Medicare's IPPE is an ideal time to advise new Medicare beneficiaries regarding what they should and should not do to maximize their ability to be healthy and functionally independent into their 80s, 90s, and 100s.
Body care activities and its consequences related to COVID‐19 pandemic
Authors: Mościcka Patrycja 
Published: August 2022

AbstractBackgroundSymptoms of illnesses related to COVID‐19 disease include also dermatological changes. Moreover, modification of cosmetic and hygenic habits are widely noted.AimThe aim of this paper is to review the literature focused on skin manifestations related to COVID‐19 disease.Materials and MethodsIn order to obtain information contained in this review article electronic databases, such as Google Scholar and PubMed, was searched. Only peer‐reviewed articles published in the past two years have been studied.Results and DiscussionPeople have changed their cosmetics and hygenic habits, what has an impact on spreading COVID‐19 disease, as well as on the beauty industry and human health.ConclusionMore emphasis should be placed on increasing knowledge about skin lesions, which may appear in course of the disease or are associated with changes in hygenic and cosmetics habits.
Exposure to screen time and dental neglect
Authors: Yilmaz Nagehan , Avci Gizem 
Published: August 2022

AimDental neglect is the failure of parents to meet a child's basic oral health needs and causes complications. Long screen time, and its health impact, is an important public health issue. This study is aimed at determining whether there is a relationship between screen time of children and parents and dental neglect.MethodsTwo hundred and fifteen patients were included in this cross‐sectional observational study. A questionnaire including questions exploring demographic data, children's life‐styles and, screen time of both parents and children. A dental neglect scale was administered to the parents. The children's intraoral examinations were evaluated using the decayed, missing, filled teeth (dmft) and pulp, ulcers, fistula, abscess (pufa) indices.ResultsMultivariable linear regression analysis showed that dental neglect was statistically significantly associated with brushing teeth unsupervised and infrequently, frequent snacking, rarely doing exercise, screen exposure at an early age and presence of dental plaque (P < 0.05). Long screen time was statistically significantly associated with high dmft scores, reflecting poor oral health. It was found that children who did not attend daycare, had statistically significantly longer exposure to screens, compared to those who attended daycare.ConclusionsEarly exposure to screens and long‐term screen use are associated with adverse outcomes pertaining to children's oral health.
Anaplastic ganglioglioma—A diagnosis comprising several distinct tumour types
Authors: Reinhardt Annekathrin , Pfister Kristin , Schrimpf Daniel , Stichel Damian , Sahm Felix , Reuss David E. , Capper David , Wefers Annika K. , Ebrahimi Azadeh , Sill Martin , Felsberg Joerg , Reifenberger Guido , Becker Albert , Prinz Marco , Staszewski Ori , Hartmann Christian , Schittenhelm Jens , Gramatzki Dorothee , Weller Michael , Olar Adriana , Rushing Elisabeth Jane , Bergmann Markus , Farrell Michael A. , Blümcke Ingmar , Coras Roland , Beckervordersandforth Jan , Kim Se Hoon , Rogerio Fabio , Dimova Petia S. , Niehusmann Pitt , Unterberg Andreas , Platten Michael , Pfister Stefan M. , Wick Wolfgang , Herold‐Mende Christel , von Deimling Andreas 
Published: August 2022

AbstractAimsAnaplastic ganglioglioma is a rare tumour, and diagnosis has been based on histological criteria. The 5th edition of the World Health Organization Classification of Tumours of the Central Nervous System (CNS WHO) does not list anaplastic ganglioglioma as a distinct diagnosis due to lack of molecular data in previous publications. We retrospectively compiled a cohort of 54 histologically diagnosed anaplastic gangliogliomas to explore whether the molecular profiles of these tumours represent a separate type or resolve into other entities.MethodsSamples were subjected to histological review, desoxyribonucleic acid (DNA) methylation profiling and next‐generation sequencing. Morphological and molecular data were summarised to an integrated diagnosis.ResultsThe majority of tumours designated as anaplastic gangliogliomas resolved into other CNS WHO diagnoses, most commonly pleomorphic xanthoastrocytoma (16/54), glioblastoma, isocitrate dehydrogenase protein (IDH) wild type and diffuse paediatric‐type high‐grade glioma, H3 wild type and IDH wild type (11 and 2/54), followed by low‐grade glial or glioneuronal tumours including pilocytic astrocytoma, dysembryoplastic neuroepithelial tumour and diffuse leptomeningeal glioneuronal tumour (5/54), IDH mutant astrocytoma (4/54) and others (6/54). A subset of tumours (10/54) was not assignable to a CNS WHO diagnosis, and common molecular profiles pointing to a separate entity were not evident.ConclusionsIn summary, we show that tumours histologically diagnosed as anaplastic ganglioglioma comprise a wide spectrum of CNS WHO tumour types with different prognostic and therapeutic implications. We therefore suggest assigning this designation with caution and recommend comprehensive molecular workup.
“We're socialists not nationalists”: British labour and the national question(s)
Authors: Brown Swan Coree 
Published: August 2022

AbstractThe UK Labour Party, which in government delivered devolution to Scotland and Wales, has struggled to adapt to a multilevel and increasingly territorialised political space, where demands for significant territorial reform grow ever louder. These challenges intensified with the Scottish independence referendum and the United Kingdom's exit from the European Union. During this prolonged constitutional moment, the Labour Party has had to articulate the case for a plurinational and multicultural British identity and for the Union, and to a large degree, has struggled to do so. Capturing the period from 2012 to 2020, this article examines the discursive strategies adopted by the Labour Party and individuals within it. It identifies a deep discomfort, more pronounced in London and Edinburgh than in Cardiff, with the national questions and a reliance on largely instrumental arguments, albeit ones rooted in traditional left‐wing values of welfare and social solidarity between working people.
Plant UVRAG interacts with ATG14 to regulate autophagosome maturation and geminivirus infection
Authors: Wang Yan , Li Jinlin , Wang Jingran , Han Ping , Miao Shulei , Zheng Xiyin , Han Meng , Shen Xueqi , Li Huangai , Wu Ming , Hong Yiguo , Liu Yule 
Published: August 2022

Summary

Autophagy is an essential degradation pathway that assists eukaryote survival under multiple stress conditions. Autophagosomes engulfing cargoes accomplish degradation only when they have matured through fusing with lysosomes or vacuoles. However, the molecular machinery mediating autophagosome maturation in plants remains unknown.

Using the combined approaches of mass spectrometry, biochemistry, reverse genetics and microscopy, we uncover that UVRAG, a subunit of the class III phosphatidylinositol 3‐kinase complexes in Nicotiana benthamiana, plays an essential role in autophagsome maturation via ATG14‐assisted recruitment to autophagosomes and by facilitating RAB7 activation.

An interaction between N. benthamiana UVRAG and ATG14 was observed in vitro and in vivo, which strikingly differed from their mutually exclusive appearance in different PI3KC3 complexes in yeast and mammals. This interaction increased the localisation of UVRAG on autophagosomes and enabled the convergence of autophagic and late endosomal structures, where they contributed to fusions between these two types of organelles by recruiting the essential membrane fusion factors RAB7 GTPase and the homotypic fusion and protein sorting (HOPS) complex. In addition, we uncovered a joint contribution of ATG14 and UVRAG to geminiviral infection, beyond autophagy.

Our study provides insights into the mechanisms of autophagosome maturation in plants and expands the understanding of organisations and roles of the PI3KC3 complexes.
Biologics to breast milk: A cross‐sectional study of popular eczema treatment content on TikTok
Authors: Khan Sabrina , Yee Danielle , Khan Samiya , Mehta Manan , Zagona‐Prizio Caterina , Maynard Nicole , Reddy Rasika , Armstrong April W. 
Published: August 2022

AbstractWe conducted a cross‐sectional study to compare viewer engagement, content quality and viewer experience of eczema related medical content on TikTok between health care professionals and non‐health care professionals. Compared to non‐health care professionals, health care professionals created videos of higher quality and superior viewing experience. Viewer engagement did not differ significantly between videos made by health care professionals and non‐health care professionals. Overall, content creators should focus on producing comprehensive, evidence‐based videos.
Toward a Holistic Understanding and Models of Nonphotochemical Quenching Effects on In Vivo Fluorometry of Chlorophyll a in Coastal Waters
Authors: Xie Yuyuan , Wikfors Gary H. , Dixon Mark S. , Guy Lisa , Krisak Melissa , Li Yaqin 
Published: August 2022

ABSTRACTNonphotochemical quenching (NPQ) is known to depress in vivo fluorescence (IVF) of chlorophyll a (Chla) in aquatic environments, which makes it difficult to interpret the hour‐to‐hour variations in Chla measured by in situ fluorometers. We hypothesized that ratios between quenched and unquenched IVF are a function of both NPQ and photochemical quenching. In this study, two diatom model species Thalassiosira pseudonana (CCMP1335) and Thalassiosira weissflogii (CCMP1047) incubated under a sinusoidal light:dark cycle were studied; IVF was recorded continuously, and Chla and photo‐physiological variables were measured seven times a day. The maximal decline in Chla‐specific IVF (IVFB) attributable to quenching was 50% under the experimental settings. An NPQ and photochemical quenching‐based modeling equation exhibited a better match to the measured IVFB than equations representing the sole NPQ effect. Photochemical quenching induced by measuring light beam varied substantially during the day, and the part of the model for this process is excitation intensity‐dependent (which is differed between models of in situ fluorometers, implying no straightforward method to correct Chla for all instrument models, instrument‐specific parameterization is required). The forms of the IVFB‐light relationship are discussed as well. The findings foster a holistic understanding of NPQ effects on in vivo Chla fluorometry.
Adjacent and Nonadjacent Dipyrimidine Photoproducts as Intrinsic Probes of DNA Secondary and Tertiary Structure†
Authors: Taylor John‐Stephen 
Published: August 2022

AbstractWhile the photochemistry of duplex DNA has been extensively studied, the photochemistry of nonduplex DNA structures is largely unexplored. Because the structure and stereochemistry of DNA photoproducts depend on the secondary structure and conformation of the DNA precursor, they can serve as intrinsic probes of DNA structure. This review focuses on the structures and stereoisomers of pyrimidine dimer photoproducts arising from adjacent and nonadjacent pyrimidines in A, B and denatured DNA, bulge loops, G‐quadruplexes and reverse Hoogsteen hairpins and methods for their detection.
Informal care burden during the COVID‐19 pandemic in Flanders, Belgium: The role of perceived threat, personality and resilience
Authors: De Coninck David , Van Doren Shauni , Matthijs Koen , Declercq Anja 
Published: August 2022

AbstractBackgroundIn this study, we investigate how socio‐demographic characteristics (age, gender and education) and informal care relationship characteristics (e.g., time spent on care, number of informal caregivers, professional care) are linked with informal care burden during the COVID‐19 pandemic. In addition, we expect this burden to differ by personality characteristics, degree of resilience, and—in this specific context—perceived the COVID‐19 threat.MethodWe used the fifth wave of a longitudinal study to identify 258 informal caregivers. These online survey data came from a five‐wave longitudinal study in Flanders, Belgium that ran from April 2020 to April 2021. Data were representative of the adult population by age and gender. Analyses include t‐tests, ANOVA, SEM and binomial logistic regression.ResultsWe found that the informal care burden was strongly linked with a socio‐economic gradient, time investment changes in care since the start of the pandemic, and whether there was more than one informal caregiver. Personality traits such as agreeableness and openness to experience, and the perceived threat of COVID‐19 were also related to care burden.ConclusionsDuring the pandemic, informal caregivers were put under extra considerable pressure: restrictive government measures sometimes led to the temporary suspension of some or all professional care for persons with care needs, which may have resulted in a growing psychosocial burden. We recommend that, in the future, the focus should be on supporting the mental wellbeing and social participation of caregivers along with measures to protect caregivers and their relatives from COVID‐19. Support structures for informal caregivers should be kept running during crises now and in the future, but it is also important to adopt a case‐by‐case basis to consider support for informal caregivers.
Tools for monitoring toxicological and genotoxicological changes in a drinking water treatment plant in Northeast Italy
Authors: Alias Carlotta , Feretti Donatella , Benassi Laura , Zerbini Ilaria , Zani Claudia , Sorlini Sabrina 
Published: August 2022

AbstractDrinking water quality can be compromised at different stages, from raw water to treated one. This research aimed to evaluate the toxicity and genotoxicity of groundwater contaminated by fluorinated compounds treated in a drinking water treatment plant, through several bioassays. Water samples underwent chemical analyses and were assayed on Daphnia magna, Pseudokirchneriella subcapitata, Allium cepa, human leukocytes and Salmonella typhimurium. Physical–chemical parameters were always within the Italian legislation limits. Water after filtration and disinfection caused slight toxicity in D. magna; the sample after filtration inhibited the proliferation of P. subcapitata. None of the water samples exerted toxicity in A. cepa. All the analysed samples had genotoxic effects on A. cepa and human leucocytes, while only disinfected water caused mutations in S. typhimurium. A battery composed of tests on D. magna, P. subcapitata, S. typhimurium and A. cepa could represent a useful tool to verify the toxicity/genotoxicity through the water treatment stages and to improve drinking water quality management.
Hydrogen Thermal-Powered Aircraft Combustion and Propulsion System
Authors: Palies Paul P. 
Published: August 2022

Abstract
This article presents an assessment study of the propulsion system, the fuel distribution system, and the injector/combustor technologies enabling to eliminate of CO2 emissions in aviation. In addition, the discussion is on NOx reduction methods and mitigation technologies, and a concept to fully eliminate NOx is proposed. To design and deploy an advanced thermal-powered aircraft based on liquid hydrogen fuel in future, it is important to provide key estimates that support feasibility of the methods and technologies developed and explored in this paper. This is conducted here for a typical narrow-body aircraft that will be retrofitted and considered. Once the design space and performance requirements are introduced, a compact low emission combustor including all components is discussed to operate with hydrogen swirled combustion to equip the turbofan engines of this conceptualized aircraft. The fuel tank is not only discussed with respect to the difference in power per unit volume and per unit mass between sustainable aviation fuel (SAF) and H2 but also taking into account the Breguet range. This demonstrates that the volume of the tanks does not need to be four times more voluminous between H2 and SAF. The paper also presents a thermodynamics performance analysis for SAF fuel that is used to retrofit the engine with hydrogen fuel keeping inlet and outlet combustor stagnation temperatures equivalent. A method to derive the required flow split for future premixed combustor is described and conserve identical thermal power between SAF and H2 fuels. Flame stabilization critical challenges are also introduced.