bluuebunny/crossref_metadata_2025_split huggingface dataset:
How and Why Do Judges Cite Academics? Evidence from the Singapore High Court
Authors: SOH Jerrold Tsin Howe , GOH Yihan 
Published: May 2022

AbstractLegal academics were once thought to be parasitic on the work of judges, so much so that citing academic work was said to weaken a judgment's authority. Recent times have however seen prominent academics appointed to the highest courts, and judicial engagement with academic materials appears to have increased. In this light, this article empirically studies academic citation practices in the Singapore High Court. Using a dataset of 2,772 first-instance High Court judgments, we show that citation counts have indeed increased over time. This increase was distributed across most legal areas, and was not limited to, though more pronounced in, judgments authored by judges with post-graduate law degrees. Books, not journal articles, have consistently accounted for the bulk of the court's citations. The study sheds new statistical light on the evolving relationship between judges and academics, particularly in the context of an Asian, first-instance court.
Is Postoperative Radiotherapy Needed in the Management of Adult Craniopharyngiomas?
Authors: Khriguian Julia , Tolba Marwan , Khosrow-Khavar Farzin , Kordlouie Sarah , Guiot Marie-Christine , Abdulkarim Bassam , Shenouda George , Sirhan Denis , Souhami Luis , Panet-Raymond Valerie 
Published: May 2022

ABSTRACT:Background:The optimal treatment of adult craniopharyngioma (CP) remains controversial. Although benign, these tumors tend to recur locally. The choice between gross total resection (GTR) versus subtotal resection (STR) with adjuvant or delayed radiotherapy (RT) is debated. The objective of this study is to review our experience with adult CPs over a 20-year period and identify an optimal management strategy.Methods:From 1999 to 2020, we reviewed all patients diagnosed with CP at our institution. We collected data regarding tumor characteristics, treatments, and toxicity. Disease progression was defined as growth on imaging. Descriptive statistics were used to assess patient characteristics. The Kaplan Meier method was used to assess progression-free survival (PFS) and corresponding 95% confidence intervals (CI) from the time since treatment initiation.Results:Twenty-four patients with a median age of 50 were included in this study. The median follow-up was 85 months. Seven patients had initial GTR, 10 STR, and 7 STR + RT. The overall 5-year PFS was 56% (95% CI: 38–83%): 100% in the STR + RT group, 69% in the GTR group, and 18% in the STR group (p = 0.01). Of the 17 patients initially treated with surgery alone, 3 with GTR and 6 with STR required salvage RT at a median of 46 months, with no further progression after salvage RT.Conclusions:Our study underscores the importance of RT for local control and suggests that STR + RT should be considered a viable option in the management of these tumors as it may be associated with improved PFS compared to surgery alone.
CELLULAR CATEGORIES AND STABLE INDEPENDENCE
Authors: LIEBERMAN MICHAEL , ROSICKÝ JIŘÍ , VASEY SEBASTIEN 
Published: May 2022

AbstractWe exhibit a bridge between the theory of cellular categories, used in algebraic topology and homological algebra, and the model-theoretic notion of stable independence. Roughly speaking, we show that the combinatorial cellular categories (those where, in a precise sense, the cellular morphisms are generated by a set) are exactly those that give rise to stable independence notions. We give two applications: on the one hand, we show that the abstract elementary classes of roots of Ext studied by Baldwin–Eklof–Trlifaj are stable and tame. On the other hand, we give a simpler proof (in a special case) that combinatorial categories are closed under 2-limits, a theorem of Makkai and Rosický.
Quail egg homogenate with zinc as adjunctive therapy in seasonal allergic rhinitis: a randomised, controlled trial
Authors: Andaloro C , Saibene A M , La Mantia I 
Published: May 2022

AbstractObjectiveBecause most available treatments for managing seasonal allergic rhinitis show some side effects without reducing recurrence, natural anti-allergic products could represent an interesting treatment addition. This study aimed to analyse the efficacy and tolerance of quail egg as adjunctive therapy in seasonal allergic rhinitis.MethodIn a Consolidated Standards of Reporting Trials compliant framework, patients with seasonal allergic rhinitis were prospectively randomised to receive mometasone nasal spray for four weeks or the same topical corticosteroid therapy plus commercially available oral quail egg and zinc tablets.ResultsForty patients were enrolled. The mometasone + quail egg and zinc tablets group showed a greater reduction in nasal itching, sneezing and total nasal symptom scores than the mometasone nasal spray only group. A higher proportion of participants in the mometasone + quail egg and zinc tablets group had good rhinitis control than in the mometasone nasal spray only group, with no need for rescue medications.ConclusionDespite the need for a further larger study, quail egg preliminarily appears to be an effective adjunct to topical steroid therapy in seasonal allergic rhinitis.
Brahman wives and pedagogies of conscience in mid-nineteenth century British India
Authors: Koven Seth 
Published: May 2022

AbstractThis article argues that fromcirca1845–1857, British colonial officials and administrators, abetted by Protestant missionaries and some so-called ‘native Christians’, attempted to replace Brahmanical regulation of everyday life with what I am calling ‘governance by conscience’ in British India. It uses the 1851 legal ruling inNarayen Ramchundur versus Luxmeebae, hailed by some for bringing ‘liberty of conscience’ and condemned by others as a wanton violation of Hindu personal law, to elucidate the connections between the Caste Disabilities Removal Act of 1850 (Act XXI) and education. My analysis highlights the centrality of Brahman wives and gender to debates about conscience, caste, property, and Christian conversion. During the violent summer of 1857, some condemned the Act and its use in deciding the case ofNarayen Ramchundur versus Luxmeebaeas provocation for the traumatic disorders then threatening to dismantle Britain's Indian empire.
Elephant ivory, rhino horn, pangolin and helmeted hornbill products for sale at the Myanmar–Thailand–China border
Authors: Vigne Lucy , Nijman Vincent 
Published: May 2022

SummaryWhile many species are affected by trafficking in their products, some take centre stage, including elephants, rhinos, pangolins and helmeted hornbills, and we report an open trade that continued in these items in eastern Myanmar between 2015 and 2020. We surveyed Myanmar’s border towns of Tachilek and Mong La, recording volumes, prices, origins and trade routes. We observed c. 16 500 ivory items, 8 helmeted hornbill casques and 264 beads, over 100 African rhino horn items and over 250 pangolins (mainly skins and scales). In 2020, asking prices in Mong La for rhino horn tips were US$10 770, rhino horn bracelets US$5385, helmeted hornbill casques US$2424 and big ivory bangles c. US$800, with prices being stable overall since 2017. We estimate the combined monetary values at US$0.25–0.30 million for Tachilek and US$0.75–2.00 million for Mong La. Mong La’s market today far surpasses Tachilek’s, being on the border of mainland China. Mobile phones and online trading allow customers to order items without bothering to cross the borders. Commitment to address the illegal wildlife trade across Myanmar’s borders requires a greater degree of cooperation and coordination amongst the relevant authorities in Myanmar, China and Thailand.
Infradiaphragmatic partial anomalous pulmonary venous connection in adulthood. Considerations for management: a single centre experience
Authors: Cavalla Francesca , Nuri Halkawt A. , Pomè Giuseppe , Cipriani Adriano 
Published: May 2022

AbstractBackground and objectives:Infradiaphragmatic partial anomalous pulmonary venous connection is occasionally diagnosed in adulthood. Management of infradiaphragmatic PAPVC depends on anatomy and clinical presentation.Methods:Over a 10-year period, we observed seven adult patients (median age 29 years) with partial anomalous pulmonary venous connection. We classified our patients in two groups. Group I: isolated partial anomalous pulmonary venous connection from one pulmonary lobe to the inferior vena cava, three patients. Group II: partial anomalous pulmonary venous connection of the entire right lung to IVC, four patients.Results:The mean term follow-up was 5.4 years. Patients in Group I have been managed conservatively, as they were asymptomatic, without a significant shunt. Patients in Group II were surgically corrected using long right intra-atrial baffles. After 6 months of follow-up, the first two cases were diagnosed with complete tunnel thrombosis and loss of right lung function. Oral anticoagulation failed to recanalize the tunnel. Considering this serious complication, the other two patients were empirically and preventively treated with anticoagulation after surgery, with good outcome on long-term follow-up.Conclusions:Conservative management should be considered for asymptomatic patients, without a significant shunt. Surgical treatment of infradiaphragmatic partial anomalous pulmonary venous connection of the entire right lung in inferior vena cava is challenging. Slow blood flow inside the long intra-atrial baffles inclines to thrombosis and occlusion, as we observed in two cases. Therefore, oral anticoagulation should be considered for long baffles with slow blood flow.
Neighbourhood walkability and dietary attributes: effect modification by area-level socio-economic status
Authors: Chandrabose Manoj , Cao Yingting (Tina) , Hadgraft Nyssa , Higgs Carl , Shuvo Faysal , Dunstan David W , Owen Neville , Sugiyama Takemi 
Published: May 2022

AbstractObjective:Higher neighbourhood walkability would be expected to contribute to better health, but the relevant evidence is inconsistent. This may be because residents’ dietary attributes, which vary with socio-economic status (SES) and influence their health, can be related to walkability. We examined associations of walkability with dietary attributes and potential effect modification by area-level SES.Design:The exposure variable of this cross-sectional study was neighbourhood walkability, calculated using residential density, intersection density and destination density within 1-km street-network buffer around each participant’s residence. The outcome variables were dietary patterns (Western, prudent and mixed) and total dietary energy intake, derived from a FFQ. Main and interaction effects with area-level SES were estimated using two-level linear regression models.Setting:Participants were from all states and territories in Australia.Participants:The analytical sample included 3590 participants (54 % women, age range 34 to 86).Results:Walkability was not associated with dietary attributes in the whole sample. However, we found interaction effects of walkability and area-level SES on Western diet scores (P < 0·001) and total energy intake (P = 0·012). In low SES areas, higher walkability was associated with higher Western dietary patterns (P = 0·062) and higher total energy intake (P = 0·066). In high SES areas, higher walkability was associated with lower Western diet scores (P = 0·021) and lower total energy intake (P = 0·058).Conclusions:Higher walkability may not be necessarily conducive to better health in socio-economically disadvantaged areas. Public health initiatives to enhance neighbourhood walkability need to consider food environments and socio-economic contexts.
Flies, tigers, and the leviathan: anti-corruption campaigns and popular political support in China
Authors: Huhe Narisong , Chen Jie , Chen Yongguo 
Published: May 2022

AbstractTo bolster its legitimacy, China's authoritarian regime has launched numerous anticorruption campaigns. Many of these anticorruption campaigns seemed tainted by intra-elite competition and only effective at deterring low- and mid-level cadres (i.e., ‘flies’). Yet, Xi's campaign differs notably from previous ones in his targeting of senior officials (i.e., ‘tigers’) and introduction of institutional changes. By integrating anti-corruption data with three waves of nationwide surveys conducted in 36 major cities in China (2011, 2012, and 2015), we explore and compare the impacts of anti-corruption campaigns on popular political support under Hu and Xi. Our analysis shows that the overall popular support has declined steadily overtime, despite the positive effects of Xi's anti-corruption campaign. Specifically, ordinary Chinese did react positively to Xi's anticorruption campaign. Xi's campaign, particularly his crackdown on ‘tigers,’ increased people's trust in the central government. However, the campaign fell short in restoring the decline of central and local government legitimacy.
Communicating is analogous to caring: A systematic review and thematic synthesis of the patient–clinician communication experiences of individuals with ovarian cancer
Authors: Pozzar Rachel A. , Berry Donna L. 
Published: May 2022

AbstractObjectiveTo systematically review and synthesize the patient–clinician communication experiences of individuals with ovarian cancer.MethodsThe CINAHL, Embase, MEDLINE, PsycINFO, and Web of Science databases were reviewed for articles that described (a) original qualitative or mixed methods research, (b) the experiences of individuals with ovarian cancer, and (c) findings related to patient–clinician communication. Relevant data were extracted from study results sections, then coded for descriptive and analytical themes in accordance with Thomas and Harden's approach to thematic synthesis. Data were coded by two authors and discrepancies were resolved through discussion.ResultsOf 1,390 unique articles, 65 met criteria for inclusion. Four descriptive themes captured participants’ experiences communicating with clinicians: respecting me, seeing me, supporting me, and advocating for myself. Findings were synthesized into three analytical themes: communication is analogous to caring, communication is essential to personalized care, and communication may mitigate or exacerbate the burden of illness.Significance of resultsPatient–clinician communication is a process by which individuals with ovarian cancer may engage in self-advocacy and appraise the extent to which they are seen, respected, and supported by clinicians. Strategies to enhance patient–clinician communication in the ovarian cancer care setting may promote patient perceptions of patient-centered care.
Availability of vitamin B12 and its lower ligand intermediate α-ribazole impact prokaryotic and protist communities in oceanic systems
Authors: Wienhausen Gerrit , Dlugosch Leon , Jarling René , Wilkes Heinz , Giebel Helge-A , Simon Meinhard 
Published: May 2022

Abstract
Genome analyses predict that the cofactor cobalamin (vitamin B12, called B12 herein) is produced by only one-third of all prokaryotes but almost all encode at least one B12-dependent enzyme, in most cases methionine synthase. This implies that the majority of prokaryotes relies on exogenous B12 supply and interacts with producers. B12 consists of a corrin ring centred around a cobalt ion and the lower ligand 5’6-dimethylbenzimidazole (DMB). It has never been tested whether availability of this pivotal cofactor, DMB or its intermediate α-ribazole affect growth and composition of prokaryotic microbial communities. Here we show that in the subtropical, equatorial and polar frontal Pacific Ocean supply of B12 and α-ribazole enhances heterotrophic prokaryotic production and alters the composition of prokaryotic and heterotrophic protist communities. In the polar frontal Pacific, the SAR11 clade and Oceanospirillales increased their relative abundances upon B12 supply. In the subtropical Pacific, Oceanospirillales increased their relative abundance upon B12 supply as well but also downregulated the transcription of the btuB gene, encoding the outer membrane permease for B12. Surprisingly, Prochlorococcus, known to produce pseudo-B12 and not B12, exhibited significant upregulation of genes encoding key proteins of photosystem I + II, carbon fixation and nitrate reduction upon B12 supply in the subtropical Pacific. These findings show that availability of B12 and α-ribazole affect growth and composition of prokaryotic and protist communities in oceanic systems thus revealing far-reaching consequences of methionine biosynthesis and other B12-dependent enzymatic reactions on a community level.
Variation in depressive symptom trajectories in a large sample of couples
Authors: Csajbók Zsófia , Štěrbová Zuzana , Jonason Peter K. , Cermakova Pavla , Dóka Ádám , Havlíček Jan 
Published: May 2022

AbstractThe occurrence of depression is influenced by social relationships, however, most studies focus on individuals, not couples. We aimed to study how depressive symptoms of couples evolve over time and determine, which characteristics are associated with their distinct trajectories. A multi-centric cohort sample of 11,136 heterosexual couples (mean age = 60.76) from 16 European countries was followed for up to 12 years (SHARE study). Information on depressive symptoms measured by EURO-D scale was collected every 2 years. Dyadic growth mixture modeling extracted four distinct classes of couples: both non-depressed (76.91%); only women having consistently high depressive symptoms while men having consistently low depressive symptoms (8.08%); both having increasing depressive symptoms (7.83%); and both having decreasing depressive symptoms (7.18%). Couples with increasing depressive symptoms had the highest prevalence of relationship dissolution and bereavement. In comparison to the nondepressed class, individuals with any depressive symptoms were less psychologically and physically well. Our results suggest that distinct mechanisms are responsible for couples’ various longitudinal trajectories of depressive symptoms.
Involvement of FSP1-CoQ10-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis
Authors: Yang Ming , Tsui Michelle Grace , Tsang Jessica Kwan Wun , Goit Rajesh Kumar , Yao Kwok-Ming , So Kwok-Fai , Lam Wai-Ching , Lo Amy Cheuk Yin 
Published: May 2022

AbstractRetinal pigment epithelium (RPE) degeneration plays an important role in a group of retinal disorders such as retinal degeneration (RD) and age-related macular degeneration (AMD). The mechanism of RPE cell death is not yet fully elucidated. Ferroptosis, a novel regulated cell death pathway, participates in cancer and several neurodegenerative diseases. Glutathione peroxidase 4 (GPx-4) and ferroptosis suppressor protein 1 (FSP1) have been proposed to be two main regulators of ferroptosis in these diseases; yet, their roles in RPE degeneration remain elusive. Here, we report that both FSP1-CoQ10-NADH and GSH-GPx-4 pathways inhibit retinal ferroptosis in sodium iodate (SIO)-induced retinal degeneration pathologies in human primary RPE cells (HRPEpiC), ARPE-19 cell line, and mice. GSH-GPx-4 signaling was compromised after a toxic injury caused by SIO, which was aggravated by silencing GPx-4, and ferroptosis inhibitors robustly protected RPE cells from the challenge. Interestingly, while inhibition of FSP1 caused RPE cell death, which was aggravated by SIO exposure, overexpression of FSP1 effectively protected RPE cells from SIO-induced injury, accompanied by a significant down-regulation of CoQ10/NADH and lipid peroxidation. Most importantly, in vivo results showed that Ferrostatin-1 not only remarkably alleviated SIO-induced RPE cell loss, photoreceptor death, and retinal dysfunction but also significantly ameliorated the compromised GSH-GPx-4 and FSP1-CoQ10-NADH signaling in RPE cells isolated from SIO-induced RPE degeneration. These data describe a distinct role for ferroptosis in controlling RPE cell death in vitro and in vivo and may provide a new avenue for identifying treatment targets for RPE degeneration.
SulfoxFluor-enabled deoxyazidation of alcohols with NaN3
Authors: Guo Junkai , Wang Xiu , Ni Chuanfa , Wan Xiaolong , Hu Jinbo 
Published: May 2022

AbstractDirect deoxyazidation of alcohols with NaN3 is a straightforward method for the synthesis of widely used alkyl azides in organic chemistry. However, known methods have some limitations such as high reaction temperatures and narrow substrate scope. Herein, a general and practical method for the preparation of alkyl azides from alcohols using NaN3 has been developed. N-tosyl-4-chlorobenzenesulfonimidoyl fluoride (SulfoxFluor) plays an important role in this deoxyazidation process, which converts a broad range of alcohols into alkyl azides at room temperature. The power of this deoxyazidation protocol has been demonstrated by successful late-stage deoxyazidation of natural products and pharmaceutically relevant molecules.
Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates
Authors: Trulsson Fredrik , Akimov Vyacheslav , Robu Mihaela , van Overbeek Nila , Berrocal David Aureliano Pérez , Shah Rashmi G. , Cox Jürgen , Shah Girish M. , Blagoev Blagoy , Vertegaal Alfred C. O. 
Published: May 2022

AbstractThe ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown. Here, we compare the contributions of the proteasome and DUBs on the global ubiquitinome, using UbiSite technology, inhibitors and mass spectrometry. We uncover large dynamic ubiquitin signalling networks with substrates and sites preferentially regulated by DUBs or by the proteasome, highlighting the role of DUBs in degradation-independent ubiquitination. DUBs regulate substrates via at least 40,000 unique sites. Regulated networks of ubiquitin substrates are involved in autophagy, apoptosis, genome integrity, telomere integrity, cell cycle progression, mitochondrial function, vesicle transport, signal transduction, transcription, pre-mRNA splicing and many other cellular processes. Moreover, we show that ubiquitin conjugated to SUMO2/3 forms a strong proteasomal degradation signal. Interestingly, PARP1 is hyper-ubiquitinated in response to DUB inhibition, which increases its enzymatic activity. Our study uncovers key regulatory roles of DUBs and provides a resource of endogenous ubiquitination sites to aid the analysis of substrate specific ubiquitin signalling.