bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors Factors of Mortality Hepatocelullar Carcinoma Patients RSD dr. Soebandi Jember 2018-2020
Authors: Putra Roan Pratama , Kusuma Irawan Fajar , Handoko Adelia 
Published: November 2022

Liver cancer, predominantly Hepatocellular Carcinoma (HCC), is a tumor that originates from hepatocytes and is clinically progressive. In Indonesia, according to the Ministry of Health in 2019, liver cancer is the second most common cancer in men, amounting to 12.4 per 100,000 population with an average death rate of 7.6 per 100,000 population. There are very few studies on HCC in RSD dr. Soebandi Jember. This study aims to determine the characteristics and factors that can be predictors of death in HCC patients. This study uses an observational analytic research type with a case-control research design. The data of this study used secondary data from the medical records of HCC patients at RSD dr. Soebandi Jember, as well as primary data in the form of telephone interviews. The results of this study with a total of 72 samples showed that there was a significant difference between liver cirrhosis and HCC patient mortality within 90 days (p = 0.005), and could be used as a predictor of HCC mortality (OR = 17.15; 95% CI = 1.532-192.017).
Keywords: HCC, predictors of death, HCC mortality
Case Report: Ranula and Sublingual Glands Extirpation as Intraoral Ranula Procedures
Authors: Saputra Rizki , Rahman Sukri , Mayorita Pamelia 
Published: November 2022

Ranula is a cystic lesion that develops from saliva extravasation caused by trauma to the sublingual gland or the occurrence of duct blockages. The ranula is divided into intraoral (simple ranula) and plunging ranula. There are several options of methods in the management of ranulas such as sclerotherapy, marsupialization, and extirpation with or without gland removal involved, incision and drainage with intraoral approach, excision lesions with the extra-oral approach. A case of ranula was reported in a girl aged 12 years diagnosed with intraoral ranula (simple ranula). Treatment is done by performing ranula extirpation accompanied by the removal of the sublingual gland and its ducts. The extirpation of the ranula followed by removal of the involved sublingual salivary gland gave satisfactory results with no recurrence until 1 year of follow-up on the management of intra-oral ranula.

Keywords: ranula, simple ranula, intraoral ranula
Association of Excessive Screen Time in Children with Language Delay During Covid-19 Pandemic: A Systematic Review
Authors: Ghaisani Ulima Mazaya , Salam Amalia Rasydini 
Published: November 2022

AbstractBackground: Covid-19 pandemic and the associated of lockdown have confined children to their homes and have resulted in an exponential increase of screen use in children. The environment in which the child grows may either stimulate or inhibit their development in such a sensitive period. Language development of children starts early in infancy and surges in 2 years of life, updated knowledge about association of language delay with its aggravating risk factor, such as excessive screen time. Aim: scrutinize the association of increased risk of language delay in children under two years old with any screen time or screen time more than 1 hour in children 2-5 years old. Method: We make clinical question. We include studies from PubMed and Google Scholar on January 13th 2022. In the end, we have got three full reading articles. Result: Full reading article by Hauvel et al (2019), Varadarajan S et al (2021), and Collet M et al (2019) were choosen to discuss in this article review. Study by Hauvel et al (2019) and Varadarajan S et al (2021) describe that having screen time more than the recommendation from AAP would lead to delay language domain. Collet M et al (2019) found that children that had screen time before go to school and never discuss to their parents about what they are watching would have 6 time risk for develop primary language disorder. Conclusion: There is a correlation between excessive screen time in children and language delay.Keywords: covid-19, children, language delay, pandemic, screen time
The Zambezi deep-sea fan: mineralogical, REE, Zr/Hf, Nd-isotope, and zircon-age variability in feldspar-rich passive-margin turbidites
Authors: Garzanti Eduardo , Bayon Germain , Vermeesch Pieter , Barbarano Marta , Pastore Guido , Resentini Alberto , Dennielou Bernard , Jouet Gwenael 
Published: November 2022

ABSTRACT
We here present the first comprehensive provenance study of the Zambezi deep-sea fan, based on integrated petrographic, heavy-mineral, elemental-geochemistry, isotope-geochemistry, and detrital-zircon-geochronology analyses of middle Pleistocene to Holocene turbidites. The Zambezi Valley and Fan represent the submarine part of an ∼ 5000-km-long sediment-routing system, extending from the heart of the South African Plateau to the abyssal depths of the Indian Ocean. Sediment is derived not only from the African side, but also from Madagascar Island mostly via the Tsiribihina Valley. Being shed by two dissected rifted margins, detritus supplied from opposite sides of the Mozambique Channel shares similar feldspar-rich feldspatho-quartzose composition, although with significant differences in heavy-mineral and geochemical signatures. The εNd values of Madagascar sand are markedly more negative and TNd model ages notably older. Zircon grains yield mostly Irumide (late Stenian) U-Pb ages in African-derived sand and mostly Pan-African (Ediacaran–Cryogenian) U-Pb ages in Madagascar-derived sand, which also yields a few grains as old as Paleoarchean and many discordant ages reflecting Pan-African reworking of Archean cratonic rocks. Lower Valley and Lower Fan deposits have intermediate fingerprints, indicating that sediment supply from Madagascar is not much less than from Africa despite a much smaller catchment area, which can be explained by deposition of a conspicuous part of Africa-derived sediment in the Intermediate Basin confined between the Zambezi Shelf, the Beira High, and the Îles Éparses.
By assuming that compositional differences between Quaternary submarine deposits and modern Zambezi River sands primarily resulted from sediment impoundment by large dams, we could evaluate the anthropogenic impact on natural sediment fluxes. Quaternary turbidites are somewhat higher in quartz and poorer in heavy minerals with higher relative amounts of durable ZTR species, and yield more Ediacaran, Neoarchean, and Carboniferous detrital-zircon ages than modern river sands. The Orosirian peak characterizing the Intermediate Basin sample points to prominent supply from the middle and upper parts of the Zambezi catchment in the middle Pleistocene. Rough calculations suggest that pre-dam Zambezi sediments were generated ≤ 10% in the upper catchment, ∼ 60% in the middle catchment, and only ≥ 30% in the lower catchment that provides the totality of sediment reaching the Indian Ocean today.
Provenance of middle to late Pleistocene tills in Illinois, U.S.A.: evidence for long-distance (∼ 2000 km) ice transport during two successive glaciations
Authors: Malone David H. , Grimley David A. , Gifford Jennifer N. , Colgan Patrick M. , Craddock John P. , Phillips Andrew C. , Meister Paul A. , Lowe Theodor H. , Rickels Ellyn S. 
Published: November 2022

ABSTRACTZircons extracted from 567 granitic cobbles, in middle to late Pleistocene tills of the Lake Michigan Lobe in Illinois, provide a remarkably consistent Archean age of ∼ 2.7 Ga, with 87% dating between 2.6 and 2.8 Ga. This finding suggests a persistent glacial flow path of the southern Laurentide ice sheet from the Superior Province into the Lake Michigan basin during Marine Isotope Stage 6 (Illinois Episode) and Marine Isotope Stage 2 (Wisconsin Episode). Based on published crystalline bedrock ages in the Canadian Shield, these cobbles are interpreted to have been transported as much as ∼ 2000 km southwestward from the Quebec–Labrador ice dome, east of Hudson Bay, to the ice-sheet terminus in central to southern Illinois, USA. Some of the glacial flow likely skirted eastern Hudson Bay (source of Omar erratics) and southern James Bay, and traversed outcrops of Huronian jasper conglomerate and diamictite along the north shore of Lake Huron. Transport across the Paleozoic strata may have been enhanced, in part, by an ice stream that advanced across relatively soft and water-saturated sediments that underlie the Lake Michigan basin. The Lake Michigan basin, although present earlier in some form, was likely significantly eroded and overdeepened by accelerated glacial flow and erosion during MIS-6, further constraining the southern Laurentide Ice Sheet (LIS) flow path and influencing its subsequent flow during the last glaciation. As the Lake Michigan Lobe thinned and radiated out from the Lake Michigan basin, topographic effects led to separation of sublobes during the LIS advance to its southernmost extent.
An Asymptotic Analysis of the Gradient Remediability Problem for Disturbed Distributed Linear Systems
Authors: Rekkab Soraya , Benhadid Samir , Al-Saphory Raheam 
Published: November 2022

The goal of this work is demonstrating, through the gradient observation of a of type linear ( -systems), the possibility for reducing the effect of any disturbances (pollution, radiation, infection, etc.) asymptotically, by a suitable choice of related actuators of these systems. Thus, a class of ( -system) was developed based on finite time ( -system). Furthermore, definitions and some properties of this concept -system and asymptotically gradient controllable system ( -controllable) were stated and studied. More precisely, asymptotically gradient efficient actuators ensuring the weak asymptotically gradient compensation system ( -system) of known or unknown disturbances are examined. Consequently, under convenient hypothesis, the existence and the uniqueness of the control of type optimal, guaranteeing the asymptotically gradient compensation system ( -system), are shown and proven. Finally, an approach that leads to a Mathematical approximation algorithm is explored.
Electron lens Optimization for Beam Physics Research using the Integrated Optics Test Accelerator
Authors: Obaid Sura Allawi , Taha Jenan Hussein , Abdullah Siham 
Published: November 2022

This study proposed control system that has been presented to control the electron lens resistance in order to obtain a stabilized electron lens power. This study will layout the fundamental challenges, hypothetical plan arrangements and development condition for the Integrable Optics Test Accelerator (IOTA) in progress at Fermilab. Thus, an effective automatic gain control (AGC) unit has been introduced which prevents fluctuations in the internal resistance of the electronic lens caused by environmental influences to affect the system's current and power values ​​and keep them in stable amounts. Utilizing this unit has obtained level balanced out system un impacted with electronic lens surrounding natural varieties.
Analysis of Fuel Burnup and Transmutations at High Burnup of Sodium Fast Breeder Reactor
Authors: Mohamed Nehal , Aziz Moustafa , El Ghazaly M. , Bashter Ibrahim 
Published: November 2022

In this paper, the Monte Carlo N-Particle extended computer code (MCNP) were used to design a model of the European Sodium-cooled Fast Reactor. The multiplication factor, conversion factor, delayed neutrons fraction, doppler constant, control rod worth, sodium void worth, masses for major heavy nuclei, radial and axial power distribution at high burnup are studied. The results show that the reactor breeds fissile isotopes with a conversion ratio of 0.994 at fuel burnup 70 (GWd/T), and minor actinides are buildup inside the reactor core. The study aims to check the efficiency of the model on the calculation of the neutronic parameters of the core at high burnup.
Lorentz Microscopy of Optical Fields
Authors: Gaida John , Lourenço-Martins Hugo , Yalunin Sergey , Feist Armin , Sivis Murat , Hohage Thorsten , de Abajo Javier García , Ropers Claus 
Published: November 2022

Abstract
In electron microscopy, detailed insights into nanoscale optical properties of materials are gained by spontaneous inelastic scattering leading to electron-energy loss and cathodoluminescence. Stimulated scattering in the presence of external sample excitation allows for mode- and polarization-selective photon-induced near-ﬁeld electron microscopy (PINEM). This process imprints a spatial phase proﬁle inherited from the optical ﬁelds onto the wave function of the probing electrons. Here, we introduce Lorentz-PINEM for the full-ﬁeld, non-invasive imaging of complex optical near ﬁelds at high spatial resolution. We use energy-ﬁltered defocus phase-contrast imaging and iterative phase retrieval to reconstruct the phase distribution of interfering surface-bound modes on a plasmonic nanotip. Our approach is universally applicable to retrieve the spatial phase of nanoscale ﬁelds and topological modes.
Vertical Integrated Spiking Cone Photoreceptor Arrays for Color Perception
Authors: Wan Qing , Wang Xiangjing , Chen Chunsheng , Zhu Li , Shi Kailu , Peng Baocheng , Zhu Yixin , Mao Huiwu , Long Haotian , Ke Shuo , Fu Chuanyu , Zhu Ying , Wan Changjin 
Published: November 2022

Abstract
The cone photoreceptors in our eyes selectively transduce the natural light into spiking representations, which endows the brain with high energy-efficiency color vision. However, the cone-like device with color-selectivity and spike-encoding capability remains challenging. Here, we propose a vertical integrated spiking cone photoreceptor (VISCP) array with the structure of ITO/Ta2O5/Ag/IGZO/ITO, which can directly transduce persistent lights into spike trains at a certain rate according to the input wavelengths. The VISCPs have an ultralow power consumption of ≤400 pW per spike in visible light, which is very close to biological cones. In this work, lights with three wavelengths were exploited as pseudo three primary colors to form ‘colorful’ images for recognition tasks, and the device with the ability to discriminate mixed colors shows a better accuracy. Our results would enable hardware spiking neural networks with biologically plausible visual perception and provide great potential for the development of dynamic vision sensors.
The midbody and midbody remnant are assembly sites for RNA and active translation
Authors: Skop Ahna , Park Sungjin , Dahn Randall , Kurt Elif , Presle Adrien , VandenHeuvel Kathryn , Moravec Cara , Jambhekar Ashwini , Olukoga Olushola , Shepherd Jason , Echard Arnaud , Blower Michael 
Published: November 2022

Abstract
The midbody (MB) is a transient structure at the spindle midzone that is required for cytokinesis, the terminal stage of cell division. Long ignored as a vestigial remnant of cytokinesis, we now know MBs are released post-abscission as extracellular vesicles called MB remnants (MBRs) and can modulate cell proliferation, fate decisions, tissue polarity, neuronal architecture, and tumorigenic behavior. Here, we demonstrate that the MB matrix—the structurally amorphous MB core of unknown composition—is the site of ribonucleoprotein assembly and is enriched in mRNAs that encode proteins involved in cell fate, oncogenesis, and pluripotency, that we are calling the MB granule. Using a quantitative transcriptomic approach, we identified a population of mRNAs enriched in mitotic MBs and confirmed their presence in signaling MBR vesicles released by abscission. The MB granule is unique in that it is translationally active, contains both small and large ribosomal subunits, and has both membrane-less and membrane-bound states. Both MBs and post-abscission MBRs are sites of spatiotemporally regulated translation, which is initiated when nascent daughter cells re-enter G1 and continues after extracellular release. We demonstrate that the MB is the assembly site of an RNP granule. MKLP1 and ARC are necessary for the localization and translation of RNA in the MB dark zone, whereas ESCRT-III was necessary to maintain translation levels in the MB. Our data suggest a model in which the MB functions as a novel RNA-based organelle with a uniquely complex life cycle. We present a model in which the assembly and transfer of RNP complexes are central to post-mitotic MBR function and suggest the MBR serves as a novel mode of RNA-based intercellular communication with a defined biogenesis that is coupled to abscission, and inherently links cell division status with signaling capacity. To our knowledge, this is the first example of an autonomous extracellular vesicle with active translation activity.
Automatic Prediction Model of Overall Survivalin Prostate Cancer Patients with BoneMetastasis using Deep Neural Networks
Authors: Wang Zhongxiao , Xiong Tianyu , Jiang Mingxin , Cui Yun , Qian Xiaosong , Su Yao , Zhang Xiaolei , Xu Shiqi , Wen Dong , Dong Xianling , Yang Mingfu , Niu Yinong 
Published: November 2022

Abstract
Background: Bone was the most common site of metastasis in prostate cancer(PCa) patients and was correlated with poor prognosis and increasing economicalburden. Studies were limited on the prognostic prediction for metastatic PCapatients with the assistance of neural network.
Methods: Four convolutional neural network (CNN) models were developed andevaluated to predict overall survival (OS) of PCa patients with bone metastasis.All the CNN models were first trained with 64 samples and evaluated with 10samples, two models used only bone scan images and two models used both bonescan images and clinical parameters (CPs). Predictions of the best models werecompared with those of two urology surgeons on 20 test samples.
Results: Our best models could predict OS of PCa patients with bone metastasiswith AUC = 0.8022 by using only bone scan images and AUC = 0.8132 by usingboth bone scan image and CPs on 20 test samples. When the sensitivities(specificities) set equal to average level of urology surgeons, their specificities(sensitivities) were 0%(7.2%) and 30.77%(7.7%) higher, which showedsignificant advantages of CNN models.
Conclusion: The CNN models were suitable to predict OS in PCa patients withbone metastasis using bone scan images and CPs. Our models showed betterperformance in terms of accuracy and stability than urology surgeons.
Keywords: Bone Metastasis; Bone Scan; Convolutional Neural Network;Prostate Cancer; Overall Survival
Total Mercury Content in the Tissues of Freshwater Chelonium (Podocnemis Expansa) and a Human Health Risk Assessment for the Amazon Population in Brazil
Authors: Júnior Fábio Targino , Ribeiro Joanna Damazio de Nunes , Simões Julia Siqueira , Carneiro Carla Silva , Lazzarini Stella Maris , Souza Aline Ramos , Ferreira Micheli Silva , Mano Sérgio Borges , Esmerino Erick Almeida , Mársico Eliane Teixeira 
Published: November 2022

Abstract
Researchers are highly aware of the silent, negative effects caused by mercury pollution in gold mining areas. Freshwater turtles are culturally part of the diet of riverside populations in the Amazon region and this area presents mercury (Hg) pollution issues mainly due to gold mining activities. Thus, this research aimed to evaluate the total mercury (THg) content in the different organs of river turtles (P. expansa) and carry out a human health risk assessment associated with the consumption of these animals. Skin (n=28), muscle (n=19) and brain (n=2) samples were analyzed by Atomic Absorption Spectrometry (TDA-AAS) and a DMA-80™ mercury analyzer used for the total mercury determinations. The average values found for THg in the skin, muscle and brain samples were, respectively, 0.1045 mg.kg-1, 0.1092 mg.kg-1 and 0.0601mg.kg-1. Thus, THg was observed even though the P. expansa were kept in captivity, possibly due to previous contamination by air, water and food. The Hazard Quotient (HQ) was calculated considering a 9.07g.day-1 intake dose of P. expansa and the consumption of turtles once a week showed a HQ=2.45, which may cause long-term injuries to human health. Although the muscle concentrations were below the maximum limit established by the World Health Organization (WHO) and Brazilian regulatory agencies, it is important to evaluate consumption factors such as amount ingested, frequency and animal gender, which may cause a potential risk to regular consumers due to mercury bioaccumulation. The WHO may consider various aspects in order to warn the amazon population about the severity and silent hazard of this metal, especially due to the importance of this matrix in the region. This region urgently needs government actions to inhibit clandestine mining and to prevent future serious, chronic health problems of the entire population.
Asymptotic stability of a nonlinear energy harvester with mass disturbance undergoing Markovian jump
Authors: Dong Hao , Du Lin , Zhang Shuo , Sun Tongtong , Zhao Yunping , Deng Zichen 
Published: November 2022

Abstract
A new type of Brownian motion, stochastic mass, has received widespread attention and has had a significant impact on the dynamics of the systems with light mass and small volume. This paper investigates the asymptotic stability with probability one of a nonlinear energy harvester with mass disturbance undergoing Markovian jump. To simplify the mass disturbance, which is modeled as Gaussian white noise, an approximate non-dimensional system is established. Using the stochastic averaging method, the averaged stochastic differential equation of the amplitude in the approximate system is derived. With the linearization,we deduced the largest Lyapunov exponent of the linearized equation. Furthermore, the necessary and sufficient condition for asymptotic stability of the nonlinear energy harvester is proposed approximately by managing the largest Lyapunov exponent be negative. The effects of mass disturbance and Markovian jump on the asymptotic stability with probability one of the nonlinear energy harvester are analyzed. To verify the accuracy of the results, we calculate the displacements of the original system directly numerically. In addition, the stability regions of the nonlinear energy harvester with different transition matrixes and stochastic mass noise intensities are thoroughly studied.