bluuebunny/crossref_metadata_2025_split huggingface dataset:
The evolving landscape of sea-level rise science from 1990 to 2021
Authors: Khojasteh Danial , Haghani Milad , Nicholls Robert , Moftakhari Hamed , Sadat-Noori Mahmood , Mach Katharine , Fagherazzi Sergio , Vafeidis Athanasios , Barbier Edward , Shamsipour Abbas , Glamore William 
Published: October 2022

Abstract
As sea-level rise (SLR) accelerates due to climate change, its multidisciplinary field of science has similarly expanded, from about 50 documents in 1990 to nearly 15,000 documents from 1990 to 2021. Here, big data, bibliometric techniques are adopted to systematically analyse this growing, large-scale literature. Four main research clusters (themes) emerge: (I) geological dimensions and biogeochemical cycles, (II) impacts, risks, and adaptation, (III) physical components of sea-level change, and (IV) coastal ecosystems and habitats, with 16 associated sub-themes. This analysis provides insights into the prioritisation of research agendas, the challenges and opportunities of future integrative, global scale assessment processes (e.g., next IPCC report), and how effectively this discipline is achieving societal impact. For example, the relative importance of sub-themes evolves consistently with a decline in pure science analysis towards solution-focused topics associated with SLR risks such as surface elevation change, flooding, ice sheets dynamics, coastal erosion and squeeze, and engineered shorelines.
The Intervention Selection Toolbox to improve patient-relevant outcomes: an implementation and qualitative evaluation study in colorectal cancer surgery
Authors: Smalbroek Bo P , Vijverberg Joanna R.G. , Fahim Milad , Dijksman Lea M. , Biesma Douwe H. , Smits Anke B. , Prof Frits G. Merode , Nat Paul B. 
Published: October 2022

Abstract
Background: The concept of value-based healthcare is being used worldwide to improve healthcare. The Intervention Selection Toolbox was developed to bridge the gap of value-based healthcare, between insights in outcomes and actual quality improvement initiatives. In this study we aimed to evaluate the implementation process of the Intervention Selection Toolbox in daily practice of a quality improvement team in a hospital setting.
Methods: A mixed-methods case study design was used. The Intervention Selection Toolbox was used by a multidisciplinary quality improvement team for colorectal cancer care in a large teaching hospital. In-depth semi-structured interviews, focusing on the key elements of process evaluation, were conducted after implementation with representatives of the quality improvement team to evaluate the use of the Intervention Selection Toolbox. Quantitative data regarding improvement initiatives and degree of implementation was also collected.
Results: The use of the Intervention Selection Toolbox initially resulted in 80 potential quality improvement initiatives. Eventually, two high potential improvement initiatives were selected. Some components of the toolbox were successfully implemented in daily practice, although ‘standard monitoring’ and ‘causal chain analysis’ proved more difficult to implement. Qualitative analysis showed added value in the use of the toolbox, but identified time and organizational management as restricting factors.
Conclusions: The Intervention Selection Toolbox is useful to systematically identify improvement initiatives with impact on health outcomes that matter to patients. However, before implementation organizational structure should be optimized to maximize success and efficiency on integration of the Intervention Selection Toolbox.
Development Software Program for Extraction of Photovoltaic Cell Equivalent Cırcuıt Model Parameters Based on The Newton Raphson Method
Authors: adak suleyman , Cangi Hasan , Yilmaz Ahmet Serdar , Arifoglu Ugur 
Published: October 2022

Abstract
Finding the equivalent circuit parameters for photovoltaic (PV) cells is crucial as they are used in the modeling and analysis of PV arrays. PV cells are made of silicon semiconductor materials. These materials have a nonlinear characteristic. This distorts the sinusoidal waveform of the current and voltage. As a result, harmonic components are formed in the solar system. The PV cell is the smallest building block of the PV system and produces voltages between 0.5V and 0.7V. It serves as a source of current in the solar system. The amount of radiation hitting the cell determines how much current it produces. In an ideal case, a diode and a parallel current source make up the equivalent circuit of the PV cell. In practice, the addition of a series and parallel resistor is made to the ideal equivalent circuit. There are many equivalent circuits in the literature on modeling the equivalent circuit of a PV cell. The PV cell single diode model is the most used model due to its ease of analysis. In this study, the iterative method by Newton-Raphson was used to find the equivalent circuit parameters of a PV cell. This method is one of the most widely used methods for determining the roots of nonlinear equations in numerical analysis. In this study, five unknown parameters (Iph, Io, Rs, Rsh, m) of the PV cell equivalent circuit were quickly discovered with the software program prepared based on the Newton-Raphson method in Matlab.
Association of aldehyde exposure with sex steroid hormones among adults
Authors: Xing Weilong , Gu Wen , Liang Mengyuan , Wang Zhen , Fan Deling , Zhang Bing , Wang Lei 
Published: October 2022

Abstract
Exogenous and Endogenous exposure to aldehyde is ubiquitous. Aldehyde is closely related to human diseases, especially reproductive toxicity. However, the effect of aldehyde exposure on sex steroid hormones among adults remains uninvestigated. A total of 851 participants aged over 18 years were included in the cross-sectional analysis based on the data from National Health and Nutrition Examination Survey (NHANES) 2013–2014. Serum aldehyde concentrations were quantified through evaluated through an automated analytical method. Sex steroid hormones including total testosterone, estradiol and sex hormone binding globulin (SHBG) were detected. Multivariate linear regression models, forest plots, generalized additive model (GAM) and smooth curve fitting analysis were used to assess the associations between quartiles of aldehydes and sex steroid hormones after adjusting the potential confounders. Butyraldehyde and propanaldehyde were negatively associated with estradiol and SHBG levels in females and males, respectively. Compared with lowest quartile, β with 95% confidence intervals (95% CIs) were − 20.59 (-38.30 to -2.88) for second quartile of butyraldehyde, -8.13 (-14.92 to -1.33) and − 7.79 (-14.91 to -0.67) for second and fourth quartiles of propanaldehyde. No significant associations were observed between other aldehydes and sex hormones. In pre-menopausal women, isopentanaldehyde was inversely associated with serum total testosterone levels (Q4 vs. Q1: OR=-7.95, 95% CI: -15.62 to -0.27), while propanaldehyde was positively associated with serum estradiol concentration (Q3 vs. Q1: β = 28.88, 95% CI: 0.83 to 56.94). The third quartile of isopentanaldehyde was associated with 3.53 pg/mL higher concentration of estradiol in post-menopause (β = 3.53, 95% CI: 0.08 to 6.97). Moreover, in males under 40, butyraldehyde and heptanaldehyde were inversely related to total testosterone levels, heptanaldehyde and butyraldehyde were negatively associated with estradiol and SHBG. Decreased total testosterone, elevated estradiol, and decreased SHBG levels were found in higher quartiles of benzaldehyde, hexanaldehyde and isopentanaldehyde, and propanaldehyde, respectively in males over 60. In male participants aged 40–60, only hexanaldehyde was observed correlated with higher serum estradiol level. The research data indicated sex- and age- specific associations between 6 serum aldehydes and sex steroid hormones alterations, further studies are warranted to confirm the causal relationship and explore the underlying mechanisms.
Foliar Application of Silicon-based Nanoparticles Improve the Adaptability of Maize (Zea mays L.) in Cadmium Contaminated Soils
Authors: Ahmed Sarfraz , Iqbal Muhammad , Ahmad Zahoor , Iqbal Muhammad Aamir , Artyszak Arkadiusz , Sabagh Ayman El , Alharby Hesham F , Hossain Akbar 
Published: October 2022

Abstract
Heavy metals (HMs) are a serious threat all over the world and show a different impact on plants and human life by contaminating the plant. Among all HMs cadmium (Cd) is one of the serious metals that are absorbed by the roots of the plant and are transported from root to leaves and fruit. Cd stunted plant growth causes the death of plants, causes, and disturbance in photosynthetic machinery and nutrient homeostasis process. Based on a serious problem a controlled experiment was conducted in the Department of Botany, University of Central Punjab, Bahawalpur Campus, Bahawalpur, Pakistan on “inducing cadmium stress tolerance in maize by exogenous application of silicon nanoparticles” in an experiment with a completely randomized design (CRD) with the factorial arrangement was used with five different treatments of silicon nanoparticles Si NPs (To = control group, T1 = Si NPs @ 100 ppm, T2 = Si NPs @ 200 ppm, T3 = Si NPs @ 300 ppm and T4 = Si NPs @ 400 ppm) and three cadmium treatment (Co= control, C1 = Cd @ 15ppm and T2 = Cd @ 30 ppm( on a maize hybrid (‘SF-9515’ F1 Single cross maize hybrid) and each replicated thrice. Results of the controlled experiment indicated that the Cd at 30 ppm affects the maize plants and reduced the morphological attributes such as shoot length (39.35 cm), shoot fresh weight (9.52 g) and shoot dry weight (3.20 g), leaf pigments such as chlorophyll a (0.55 mg/g FW), chlorophyll b (0.27 mg/g FW), total contents (0.84 mg/g FW) and carotenoids contents (0.19 µg/g FW), biochemicals traits such as TSP (4.85 mg/g FW), TP (252.94 nmol/g FW), TSAA (18.92 µmol g-1 FW), TSS (0.85 mg/g FW) and antioxidant activities such as POD (99.39 min-1 g-1 FW), CAT (81.58 min-1 g-1 FW), APX (2.04 min-1 g-1 FW), and SOD (172.79 min-1 g-1 FW) but root length (87.63 cm) and root fresh weight (16.43 g) and root dry weight (6.14 g) of maize and Cd concentration in the root (2.52 µg/g-1) and shoot (0.48 µg/g-1) were increased through the application of Cd. The silicon nanoparticles (Si-NPs) treatment significantly increased all measured attributes of maize. There is highest value was noted of all the parameters such as chlorophyll a (0.91 mg/g FW), chlorophyll b (0.57 mg/g FW), total chlorophyll contents (1.48 mg/g FW), total carotenoids contents (0.40 µg/g FW), TSP (6.12 mg/g FW), TP (384.56 nmol/g FW), TSAA (24.64 µmol g-1 FW), TSS (1.87 mg/g FW), POD (166.10 min-1 g-1 FW), CAT (149.54 min-1 g-1 FW), APX (3.49 min-1 g-1 FW), and SOD (225.57 min-1 g-1 FW) in which the treatment T4 were silicon nanoparticles added at the rate of 400 ppm compared to the control group
Measuring adherence to pulmonary rehabilitation: a prospective validation study of the Dutch version of the Rehabilitation Adherence Measure for Athletic Training (RAdMAT-NL)
Authors: Ricke Ellen , Lindeboom Robert , Dijkstra Arie , Bakker Eric 
Published: October 2022

Abstract
Introduction: Adherence is important in many aspects of healthcare as it is related to clinical outcomes. To date, there is a lack of simple, reliable and valid instruments to assess the level of exercise adherence. The Rehabilitation Adherence Measure for Athletic Training (RAdMAT) is a promising instrument.
Aims: The RAdMAT addresses different aspects of adherence to rehabilitation, grouped within three subscales. A Dutch version (RAdMAT-NL) is available. The aim of this study was to re-examine the validity of the RAdMAT-NL in patients with chronic obstructive pulmonary disease (COPD). In addition, we examined if the RAdMAT-NL could be used as a single score representative of adherence.
Methods: In this prospective study participated 193 patients with COPD, who were undertaking pulmonary rehabilitation (PR) in 53 primary physiotherapy practices in The Netherlands and Belgium between January 2021 and December 2021. At 1 month, 2 and 3 months after inclusion, patients and their physiotherapist provided measures about the rehabilitation including the RAdMAT-NL. Principal Component Analysis (PCA) was performed to assess whether the RAdMAT-NL has the same scale structure as the original RAdMAT. Rasch analysis was used for testing unidimensionality of the RAdMAT-NL. Spearman’s correlations were calculated with other indicators of adherence to determine construct validity.
Results: PCA supported the three purported dimensions of the RAdMAT-NL, explaining 63% of the total variance. Rasch analysis showed that the RAdMAT-NL can be used as a single score for adherence, which supports the practical application of the instrument. Large significant correlations between the RAdMAT-NL total and subscale scores and different measures of adherence supported its validity.
Conclusion: The RAdMAT-NL can be used as an interim assessment measure for patients who are not progressing as expected. Using three domain scores to assess progress is not necessary.
Overcoming I/O bottleneck in superconducting quantum computing: multiplexed qubit control with ultra-low-power, base-temperature cryo-CMOS multiplexer
Authors: Acharya Rohith , Brebels Steven , Grill Alexander , Verjauw Jeroen , Ivanov Tsvetan , Lozano Daniel , Wan Danny , Damme Jacques Van , Vadiraj A.M. , Mongillo Massimo , Govoreanu Bogdan , Craninckx Jan , Radu Iuliana P. , de Greve Kristiaan , Gielen Georges , Catthoor Francky , Potocnik Anton 
Published: October 2022

Abstract
Large-scale superconducting quantum computing systems entail high-fidelity control and readout of large numbers of qubits at millikelvin temperatures, resulting in a massive input-output bottleneck. Cryo-electronics, based on complementary metal-oxide-semiconductor (CMOS) technology, may offer a scalable and versatile solution to overcome this bottleneck. However, detrimental effects due to cross-coupling between the electronic and thermal noise generated during cryo-electronics operation and the qubits need to be avoided. Here we present an ultra-low power radio-frequency (RF) multiplexing cryo-electronics solution operating below 15 mK that allows for control and interfacing of superconducting qubits with minimal cross-coupling. We benchmark its performance by interfacing it with a superconducting qubit and observe that the qubit’s relaxation times (T1) are unaffected, while the coherence times (T2) are only minimally affected in both static and dynamic operation. Using the multiplexer, single qubit gate fidelities above 99.9%, i.e., well above the threshold for surface-code based quantum error-correction, can be achieved with appropriate thermal filtering. In addition, we demonstrate the capability of time-division-multiplexed qubit control by dynamically windowing calibrated qubit control pulses. Our results show that cryo-CMOS multiplexers could be used to significantly reduce the wiring resources for large-scale qubit device characterization, large-scale quantum processor control and quantum error correction protocols.
Identification of major genetic loci for plant height in bread wheat
Authors: Jia Chenfei , Zhang Hongsheng , Lv Xinru , Yang Tingzhi , Qin Huimin , Wang Yalin , Hao Qianlin , Liu Wenxing , Dai Xuehuan , Zeng Jianbin , Cao Shuanghe , Ma Wujun , Xu Dengan 
Published: October 2022

Abstract
Many genetic loci for wheat plant height (PH) have been identified, and 25 dwarfing genes have been catalogued. However, major and stable genetic loci for PH have not been well documented. To identify such loci for PH, here we comprehensively summarized functionally verified or genetic dwarfing loci from QTL mapping and genome-wide association study published from 2003 to 2012. Totally, 331 QTL, 270 associated loci and 83 genes for PH were integrated onto chromosomes according to their locations in the International Wheat Genome Sequencing Consortium (IWGSC) reference genome and 65 QTL-rich clusters (QRC) were defined. Candidate genes in each QRC were predicted based on gene annotations in the IWGSC RefSeq v2.1 and the information on functional validation of homologous genes in other species. A total of 38 candidate genes were predicted for 65 QRC including three GA2ox genes in QRC-4B-IV, QRC-5A-VIII and QRC-6A-II (Rht24) as well as GA 20-oxidase 2 (TaSD1-3A) in QRC-3A-IV. These outcomes lay concrete foundations for map-based cloning of wheat dwarfing genes and application in breeding.
Sequential UV and chlorine disinfection induced change of biofilm-originated disinfection byproducts formation potential in drinking water distribution system: Effect of UV dose and influencing mechanism
Authors: Zhang Tuqiao , Li Chengzhuo , LIU XIAOWEI 
Published: October 2022

Abstract
To address the growing concern on biofilm-related disinfection byproducts (DBPs) formation in drinking water distribution system (DWDS), this study investigated the changes of biofilm-originated DBPs formation potential (bio-ori-DBPFP) in simulated continuous-flow DWDS under the impact of sequential UV and chlorine disinfection (UV/Cl2) under different UV doses and discussed the involved influencing mechanism. Overall, the bio-ori-DBPFP of pipeline following UV/Cl2 showed a more obvious change than that of pipeline following Cl2 (UV dose of 0 mJ/cm2). UV/Cl2 disinfection at UV dose of 80 mJ/cm2 produced pipeline biofilm with the minimum bio-ori-DBPFP as well as the lowest amount of protein and polysaccharide in extracellular polymeric substance (EPS). Bacterial community composition characterization together with metabolic function analysis indicated that dominant bacteria varied and metabolic function shifted due to UV/Cl2 disinfection. The correlation analysis suggested that UV/Cl2 disinfection induced a change in water matrix including organics, inorganics, bacteria, and components providing oxidation pressure for biofilm. These changed factors finally influenced the properties of biofilm EPS, which directly correlated with bio-ori-DBPFP.
Pholiota squarrosa lectin (PhoSL), a lectin binding to core-fucose specifically, inhibits HBV infection
Authors: Ouchida Tsunenori , Maeda Haruka , Akamatsu Yuka , Maeda Megumi , Takamatsu Shinji , Kondo Jumpei , Misaki Ryo , Kamada Yoshihiro , Ueda Masahiro , Ueda Keiji , Miyoshi Eiji 
Published: October 2022

Abstract
Glycosylation in host cells and viruses is an important factor in viral infection and a target for anti-viral therapy. Hepatitis B virus (HBV) is a major pathogen causing acute /chronic hepatitis. To achieve the cure, new anti-HBV agents are needed. Here we found that Pholiota squarrosa lectin (PhoSL), a lectin that specifically binds core-fucose, inhibited HBV infection to a human NTCP-expressing HepG2 cell called C4, a cell line susceptible to HBV infection. PhoSL bound to HBV particles. Fut8KO-C4 cells markedly lost HBV infectivity, and addition of PhoSL facilitated the loss of infectivity. Furthermore, we found that PhoSL blocked the activation of epidermal growth factor receptor (EGFR), a process enhancing HBV infection. Observation of the dynamics of fluorescent labeled PhoSL on C4 cells on the infection HBV showed that PhoSL-bound HBV was incorporated into host cells, suggesting that PhoSL could inhibit HBV infection after internalization. Since PhoSL reduced cccDNA formation, the process from internalization to cccDNA formation should be impaired by PhoSL. We believe that this finding should lead to development of new anti-HBV agents.
Longitudinal trajectories of suicidal ideation among Chinese medical students: the role of childhood trauma
Authors: Nan Jiang , Salina Nen , Chong Sheau Tsuey , Jiang HongJuan 
Published: October 2022

Abstract
Background: The aim of this study was to understand the longitudinal trajectory of suicidal ideation among Chinese medical students and the role of childhood trauma.
Methods: Using a whole-group sampling method, we assessed suicidal ideation in 2192 (male = 834, female = 1358) medical students on three occasions over a period of one year. The Self-rating Idea of Suicide Scale (SIOSS) and the Childhood Trauma Questionnaire-Short Form (CTQ-SF) were used to assess suicidal ideation and childhood trauma. The regression of mixed models was used to analyze the developmental trajectory of suicidal ideation.
Results: Chinese medical students scored higher on suicidal ideation than the general population, and the prevalence of suicidal ideation increased during the COVID-19 pandemic. The trajectory of suicidal ideation among Chinese medical students was divided into two groups: a low-level, slowly rising group and a high-level, continuous group. The low-level, slowly rising group had a significant time effect (B=1.57, p<0.001) and showed a slowly increasing trend. Emotional neglect, somatic neglect, emotional abuse and somatic abuse all had significant positive predictive effects for the low-risk, slowly rising group (B=0.18-0.65, P<0.01).
Conclusion: The trajectory of suicidal ideation among medical students can be divided into a low-risk, slow-rising group and a high-risk, continuous group; the more emotional neglect, somatic neglect, emotional abuse and physical abuse experienced during childhood, the more likely medical students are to develop a high-risk, continuous state of suicidal ideation.
Antibacterial and In silico evaluation of Micro and Nanocurcumin, Assessment of Wound Healing Potentiality
Authors: Othman Amal S. , Ahmed Nashwa A. , Shamekh Israa M. , Haikal Mohnad A. , Eltayb Wafa A. 
Published: October 2022

Abstract
The discovery of new inhibitory natural compounds targeting bacterial virulence is an important strategy to overcome resistance to traditional antibiotics, in the present study the antibacterial activity of micro and nano curcumin suspensions was investigated against four predominant bacterial pathogens, including E. coli, P. aeruginosa, S. aureus, and B. subtilus. In vitro antibacterial assay indicated that nanocurcumin suspension displayed significant results. Molecular docking analysis was conducted to confirm the impact of curcumin on the quorum-sensing pathway in all bacterial groups, also the pharmacokinetic properties revealed that curcumin can be classified as a drug like compound. Wound model was employed for wound healing activity in four equal groups of male albino rats, their dorsal thoracic central regions were wounded with surgical blades. The individual groups were treated daily with 5% W/W of micro and nano curcumin lotions and soframycin ointment. Topical application of nanocurcumin lotion showed marked reduction on wound area compared to the control group as wound healing reached 98.8% on the 15th of injury. ANOVA test was performed to assess the significance of mean differences. The findings from this research indicate that nanocurcumin is effective in inhibiting bacterial infections and faster the process of wound healing.