bluuebunny/crossref_metadata_2025_split huggingface dataset:
An online Parenting Intervention to Prevent affective disorders in high-risk Adolescents: The PIPA Trial Protocol
Authors: Connor Charlotte , Yap Marie , Warwick Jane , Birchwood Maximillian , De Valliere Keshiaa , Madan Jason , Melvin Glenn A , Padfield Emma , Patterson Paul , Petrou Stavros , Raynes Kerry , Stewart-Brown Sarah , Thompson Andrew 
Published: June 2022

Abstract
BackgroundAdolescent depression can place a young person at high risk of recurrence and a range of psychosocial and vocational impairments in adult life, highlighting the importance of early recognition and prevention. Parents/carers are well placed to notice changes in their child’s emotional wellbeing which may indicate risk, and there is increasing evidence that modifiable factors exist within the family system that may help reduce the risk of depression and anxiety in an adolescent. A randomised controlled trial (RCT) of the online personalised ‘Partners in Parenting’ programme developed in Australia, focused on improving parenting skills, knowledge and awareness, showed that it helped reduce depressive symptoms in adolescents who had elevated symptom levels at baseline. We have adapted this programme and will conduct an RCT in a UK setting.Methods433 family dyads (parents/carers and children aged 11-15) will be recruited through schools, social media and parenting/family groups in the UK. Following completion of screening measures of their adolescent’s depressive symptoms, parents/carers of those with elevated scores will be randomised to either receive the online personalised parenting programme or a series of online factsheets about adolescent development and wellbeing. The primary objective will be to test whether the personalised parenting intervention reduces depressive symptoms in adolescents deemed at high risk, using the parent-reported Short Mood & Feelings Questionnaire. Follow-up assessments will be undertaken at six and 15-months and a process evaluation will examine context, implementation and impact of the intervention. An economic evaluation will also be incorporated with cost-effectiveness of the parenting intervention expressed in terms of incremental cost per quality-adjusted life year gained.DiscussionHalf of mental health problems emerge before mid-adolescence and approximately three-quarters by mid 20s, highlighting the need for effective preventative strategies. However, few early interventions are family focused and delivered online. We aim to conduct a National Institute of Health Research (NIHR) funded RCT of the online personalised ‘Partners in Parenting’ programme, proven effective in Australia, targeting adolescents at risk of depression to evaluate its effectiveness, cost-effectiveness and usability in a UK setting.Trial registration {2a} ISRCTN63358736 Registered 18 September 2019https://doi.org/10.1186/ISRCTN63358736
Long-term exercise training down-regulates m6A RNA demethylase FTO expression in the hippocampus and hypothalamus: An effective intervention for epigenetic modification
Authors: Liu Shu-Jing , Cai Tong-Hui , Fang Chun-Lu , Lin Shao-Zhang , Yang Wen-Qi , Wei Yuan , Zhou Fu , Liu Ling , Luo Yuan , Guo Zhi-Yi , Zhao Ge , Li Ya-Ping , Li Liang-Ming 
Published: June 2022

Abstract
Background
Exercise boosts the health of some brain parts, such as the hippocampus and hypothalamus. Several studies show that long-term exercise improves spatial learning and memory, enhances hypothalamic leptin sensitivity, and regulates energy balance. However, the effect of exercise on the hippocampus and hypothalamus is not fully understood. The study aimed to find epigenetic modifications or changes in gene expression of the hippocampus and hypothalamus due to exercise.
Methods
Male C57BL/6 mice were randomly divided into sedentary and exercise groups. All mice in the exercise group were subjected to treadmill exercise 5 days per week for 1 h each day. After the 12-week exercise intervention, the hippocampus and hypothalamus tissue were used for RNA-sequencing or molecular biology experiments.
Results
In both groups, numerous differentially expressed genes of the hippocampus (up-regulated: 53, down-regulated:49) and hypothalamus (up-regulated:24, down-regulated:40) were observed. In the exercise group, increased level of N6-methyladenosine (m6A) was observed in the hippocampus and hypothalamus (p < 0.05). Furthermore, the fat mass and obesity-associated gene (FTO) of the hippocampus and hypothalamus were down-regulated in the exercise group (p < 0.001). In addition, the Fto co-expression genes of the mouse brain were studied and analyzed using database to detemine the potential roles of exercise-downregulated FTO in the brain.
Conclusion
The findings demonstrate that long-term exercise might elevates the levels of m6A-tagged transcripts in the hippocampus and hypothalamus via down-regulation of FTO. Hence, exercise might be an effective intervention for epigenetic modification.
Quantitative characterization of orogens through isotopic mapping
Authors: Wang Tao , Xiao Wenjiao , Collins William , Tong Ying , Hou Zeng-Qian , Huang He , Wang Xiaoxia , Lin Shoufa , Seltmann Reimar , Wang Chaoyang , Han Baofu , Li Shan , Guo Lei 
Published: June 2022

Abstract
Orogens are major sites for crustal growth on Earth. However, characterizing orogens with stages is challenging. Here we present Nd isotope mapping results of felsic and intermediate igneous rocks from eight well-studied, typical Phanerozoic orogens. The data illustrate the distribution and areas of isotopic domains ranging from highly primitive to highly evolved, which reflects their final preservation from long-term crustal growth. From the data, we calculated the areal proportion of juvenile crust and divided the orogens into (i) highly primitive (with >70% juvenile crust); (ii) primitive (70-50%; e.g., Altaids with ~58%); (iii) slightly primitive (50–30%; e.g., North American Cordillera (~48%), Newfoundland Northern Appalachian Orogen (~40%), Lachlan Orogen (~31%)); (iv) evolved (30–10%); (v) highly evolved (10–0%; e.g., Tethyan Tibet (~4%), Caledonides (~2%), Variscides (~1%), and Qinling-Dabie (<1%)). Those from (i) to (iii) quantitatively characterize and/or correspond to simple and complex accretionary orogens, and from (iv) to (v) to complex and simple collisional orogens, respectively. Our study presents a new approach for quantitatively characterizing orogens based on compositional architecture through isotope mapping, and for investigating the relationships between orogenesis and continental growth.
Mycolicibacterium smegmatis MSMEG_6580 is a novel redox-sensitive MarR-family regulator involved in the resistance to oxidative stress
Authors: Li Yuzhu , Yan Shuangquan , Huang Yu , Yu Xi , Li Tongxin , Zhen Junfeng , Lv Xi , Chen Yu , Xie Jianping 
Published: June 2022

Abstract
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis disease (TB), is a typical intracellular pathogen. Mtb has evolved sophisticated strategies to adapt to a variety of stresses. MarR-family transcription factors are involved in resistance towards external survival stresses and can regulate the transcription of multidrug efflux pumps and antioxidant enzymes in other organisms. However, whether and how Mtb MarR-family transcription factors are involved in stress responses remains elusive. In this study, we have characterized the role and mechanism of action of the MarR-type transcriptional factor Rv3095 in the response to oxidative stress by using hxlR deletion mutant and MSMEG_6581 deletion strain. The qRT-PCR results showed that HxlR repressed transcription of MSMEG_6581, and the transcription levels of hxlR and MSMEG_6581 were increased with increased concentration of H2O2. The EMSA results showed that HxlR could bind to the promoters of target genes. HxlR dimers could further form tetramer via the disulfide bonds under oxidative stress, resulting in derepression of target genes transcription. The point-mutation results identified that HxlRC11A mutant protein was impaired in oligomerization, and ultimately impacted the DNA-binding activity, which indicating a specific role of Cys11 in redox sensing. Phenotype results indicated that hxlR or MSMEG_6581 could alter the sensitivity of bacteria towards H2O2 disinfectants. In conclusion, HxlR was identified as a novel redox-sensitive transcription factor involved in mycobacteria resistance to H2O2 via unique mode.
Currency Appreciation and Productivity: Evidence from the Exchange Rate Regime Reform
Authors: Gao Yameng , Li Jie 
Published: June 2022

Abstract
We investigate the causal effect of domestic currency appreciation on exporters’ total factor productivity. By exploiting the 2005 China’s exchange rate regime reform as a quasi-natural experiment, we find that domestic currency appreciation caused by the reform increases exporters’ total factor productivity. Specifically, given a fiercer competition induced by currency appreciation, exporters strategically reallocate resources towards better-performing products, which leads to higher total factor productivity.JEL Codes: F14, F31
The significance of recycled oceanic mantle lithosphere beneath the Arctic Gakkel ridge
Authors: Yang Alexandra Yang , Langmuir Charles , Michael Peter 
Published: June 2022

Abstract
Subduction of oceanic crust has long been considered a major cause of mantle heterogeneity. By far the largest volume of recycled plates, however, is the lithospheric mantle, which is often inferred but rarely observed. Here we report evidence that the Gakkel ridge sampled a section of recycled refractory ocean lithosphere: (1) a unique group of high-Ti basalts occurs adjacent to a long sparsely magmatic zone (SMZ) that is consistent with melting of oxide gabbro hosted in ancient ocean lithosphere; (2) the SMZ itself which is 300km of ancient mantle emplaced at the surface; (3) sparse enriched basalts from the SMZ with no residual garnet signature suggesting shallow melting of ancient refractory but metasomatized lithosphere with low mantle potential temperature; (4) a gradient in composition approaching the SMZ suggesting lower extents of melting of more depleted sources. The rarity of these occurrences elsewhere shows that ordinarily recycled ocean crust and refractory lithosphere mantle are well-mixed rather than separated during mantle convection. Large volumes of recycled ocean crust as a separate reservoir would require ten times more separated, depleted mantle, which then should be common rather than rare. The enclosed basin and ultra-slow spreading rate of the Gakkel Ridge may have provided conditions where recycled oceanic mantle lithosphere was able to be preserved.
m6A RNA Methylation Regulators de fine tumor microenvironment and predict prognosis in hepatocellular carcinoma
Authors: Gu Xiangqian , Yuan Yin , Gu Chengyu , Wu Mingyu , Cai Bin 
Published: June 2022

Abstract
Background: N6-methyladenosine (m6A) modification is considered to be the most significant and abundant mRNA modification and constitutes a critical mechanism of epigenetic regulation in various tumors. However, the potential influences of these m6A regulators on the tumor immune microenvironment (TIME) and immunotherapy in hepatocellular carcinoma (HCC) remain unknown.Methods: We systematically analyzed the expressions and genetic alterations of 38 m6A regulators in HCC from the Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) database. We used unsupervised clustering algorithm to divide the samples into three patterns based on the expression profiles of mRNA modifications. Next, we constructed the m6A score model to performed association analysis for m6Ascore and clinical characteristics, total mutation burden (TMB), and the efficacy of immunotherapy.Results: We demonstrated that the expression of m6A regulators were associated with patient survival and the infiltration of immune cells. We identified two RNA modification patterns and assigned m6Ascore to each individual. Patients with a low m6Ascore had a better survival rate than those with a high m6Ascore, and patients with a high TMB and high m6Ascore had a worse survival rate. In addition, patients in the high m6Ascore group had higher PD-L1 expression than the low m6Ascore group. The low m6Ascore group showed higher immune checkpoint inhibitor responses, including anti-CTLA-4 therapy, anti-PD-1, or a combination of both, than the high m6Ascore group.Conclusions: Our results revealed the potential function of these mRNA modifcations in TIME, and identified their therapeutic value in immunotherapy.
Fever of unknown origin caused by an intracranial mesenchymal tumor with a EWSR1-CREM fusion presenting associated with IL-6/STAT3 signaling
Authors: hojo keishiro , Furuta Takuya , Komaki Satoru , Yoshikane Yukako , Kikuchi Jin , Nakamura Hideo , Ide Mizuki , Shima Saho , Hiyoshi Yusuke , Araki Junichiro , Tanaka Seiji , Ozono Shuichi , Yoshida Akihiko , Nobusawa Sumihito , Morioka Motohiro , Nishikomori Ryuta 
Published: June 2022

Abstract
BackgroundPediatric neoplastic diseases account for about 10% in fever of unknown origin (FUO), and most neoplastic diseases cases are leukemia, lymphoma, and neuroblastoma. Brain tumors are rarely reported as the cause of FUO, although craniopharyngioma, metastatic brain tumor, and Castleman's disease have been reported. We report a case of intracranial mesenchymal tumor (IMTs) with FET-CREB fusion gene, whose had inflammatory phenotype without neurological signs.Case presentationA 10-year-old girl was admitted with 2 months history of intermittent fever and headache, whereas her past history as well as her family history lacked special events. Sepsis work-up showed no pathological organism and empirical antibiotics therapy was not effective. Bone marrow examination showed a negative result. CSF examination showed elevated protein as well as cell counts and head MRI showed a hyper vascular mass lesion with contrast enhancement in the left cerebellar hemisphere. The patient underwent tumor excision, which made the intermittent fever disappear. Pathological examinations resemble those of classic angiomatoid fibrous histiocytoma (AFH) but the morphologic features are distinct from the AFH myxoid variant, then we performed break-apart fluorescence in situ hybridization (FISH) and confirmed the tumor harbored rare EWSR1-CREM fusion gene (the Ewing sarcoma breakpoint region 1 gene (EWSR1), cAMP response element binding (CREB) family gene). Consequently, we diagnose as IMT with EWSR1-CREM fusion. Elevated serum concentration of IL-6 was normalized after tumor resection, which suggested the fever could be caused by tumor-derived IL-6.ConclusionsThis is the first case of IMT with EWSR1-CREM fusion that showed paraneoplastic symptoms associated with the IL-6/STAT3 signaling pathway. Although brain tumors are rarely diagnosed as a responsible disease for FUO, they should be considered as a cause of unknown fever even in the absence of abnormal neurological findings. (285 words)
Air concern and air pollution concentration under COVID-19 both increase people’s gym sports behavior in Beijing, China
Authors: Dong Xin , Zhang Chunxiao , Yin Anqi 
Published: June 2022

Abstract
Air pollution may change people’s gym sports behavior. To test this claim, firstly we designed a questionnaire of Beijing, China and used regression models to evaluate the association between air risk perceptions and sports mode choice, results showed that people had a high possibility of switching from outdoor sports to gym sports when air concern rose. Second, using big data crawler technology and negative binomial regression model, we provided consistent evidence that a one standard deviation increased in PM2.5 concentration (fine particulate matter with diameters equal or smaller than 2.5 μm) derived from land use regression model (LUR) was positively associated with a 0.0305 and a 0.0622 standard deviation increased in gym visits without or with consideration of the COVID-19 epidemic in 2019-2020. Finally, subgroups analysis showed that urban people and males had a higher tendency to travelling to gyms under COVID-19, which needed extra additional precautions on polluted days. All in all, subjective air concern and the actual PM2.5 concentrations under COVID-19 both increased sport people’s gym sports behavior.
Development and validation of a nomogram to predict the risk of major adverse cardiovascular events in patients with non-ST-segment elevation myocardial infarction
Authors: Aihemaiti Gulandanmu , Zhang Xuehe , Zhang Tong , Hu Kaixuan , Xu Jinghong , Zhang Zhiyang , Zhao Qian , Song Ning , Liu Fen , Yang Yining , Li Xiaomei 
Published: June 2022

Abstract
ObjectivesTo analyze the factors affecting outcome in non-ST-segment elevation myocardial infarction (NSTEMI) and construct a predictive model of major adverse cardiovascular events (MACE) in patients with NSTEMI in Xinjiang using a nomogram.MethodsA total of 745 NSTEMI patients diagnosed at the First Affiliated Hospital of Xinjiang Medical University from November 2013 to April 2020 were included. After applying inclusion criteria, 733 patients were randomly divided into the modeling group (75%) and the validation group (25%). Univariate and multivariate logistic stepwise regression analyses were used to identify independent factors influencing the occurrence of MACE in NSTEMI patients, a nomogram was generated to predict MACE in NSTEMI patients, and receiver operating characteristic curves (ROC) were used to evaluate the model.ResultsUnivariate and multivariate logistic regression analysis showed that age (odds ratio [OR]: 1.04, 95% confidence interval [CI]: 1.01–1.07), white blood cell count (OR: 2.85, 95% CI: 1.24–6.56), lymphocyte count (OR: 0.22, 95% CI: 0.08–0.62), EF values (OR: 0.91, 95% CI: 0.88–0.94), and arrhythmia history (OR: 1.87, 95% CI: 1.06–3.65) were independent factors. A nomogram was then established. The area under the ROC curve of the modeling group was 0.849, and that of the validation group was 0.808. There was no difference between the groups (P = 0.162), suggesting that the model had a good predictive value.ConclusionAge, white blood cell count, lymphocyte count, EF values, arrhythmia history, are independent factors influencing MACE in NSETMI patients. Our nomogram predicts the occurrence of MACE in NSTEMI.
Evaluation of Circuit Breaker capability for re-ignition free operation of 400kV Shunt Reactor and 765kV Shunt Reactor with NGR using Controlled Switching Device
Authors: Kumar Ajay , Parikh Urmil , Perveen Rehana 
Published: June 2022

Abstract
Shunt reactor is one of the key elements exists in Extra High Voltage (EHV) power system used for voltage regulation. The current drawn by reactor is of highly inductive in nature and due to this feature, it presents constraints in current interruption by circuit breakers. The current can resume after interruption if the rate of rise of dielectric strength (RRDS) of dielectric medium is lower than rise time derivative of the recovery voltage and can results in un-successful current interruption. Based on this consideration, minimum arcing time is prescribed by Circuit Breaker (CB) manufacturer. Evaluation of re-ignition free window for EHV 420kV 80Mvar shunt reactor has been carried out in this paper as per the procedure laid out in IEC-62271-100 and IEEE-035-017 with the help of PSCAD-EMTDC software package. The results are well supported by field implemented disturbance records of controlled switching opening operation. Effect of presence of surge arrester on Transient Recovery Voltage (TRV) has been considered and elaborated. The effect of presence of neutral grounding reactor (NGR) with 765kV Shunt reactor is also discussed in this paper. The presence of NGR tends to increase the peak of TRV peak and the same has been calculated through simulations, the field results are then discussed based on the re-ignition free window calculated as per IEC 62271-100. Optimum controlled switching helps in reduction of mechanical and electromagnetic stresses generated during random switching operations of reactor. The simulation results and field reports are in good agreement and controlled switching helps in meeting the opening targets within re-ignition free window with fair accuracy.
Human Face Aging Based on Active Appearance Model Using Proper Feature Set
Authors: Khajavi Mahboubeh , ahmadyfard Alireza 
Published: June 2022

Abstract
In this paper, a simulation of the human face evolution from youth to old age is presented. The appearance of facial changes due to aging depends on various factors such as genetics, ethnicity, and lifestyle. However, the human faces in an age group have similar characteristics. These characteristics can be used to estimate the image of a person's face in the coming years. In this work, the goal is to maintain a person's appearance and accurately estimate the face at the target age; in such a way that the simulated face should be realistic and have the appearance of the texture characteristics of the target age. To achieve this goal, the number of feature points and their arrangement on the face is very important. First, we suggest proper feature points. Then, using the Active Appearance Model (AAM) method and the presented model, templates are obtained as representative of different age groups. To maintain the unique geometric characteristics of the input face and apply these characteristics to the target age template, the proposed feature point pattern and the MLS method have been used. Then, using the active appearance model method and having the target age template containing the geometric characteristics of the input face, the steps of changing the input face age to reach the target age are presented. Finally, the results of the survey, using two methods of age recognition and real image recognition (separately for man/woman images), show an average of 80.77% (male images) and 81.36% (female images) correct answers of the participants in this Polls.