bluuebunny/crossref_metadata_2025_split huggingface dataset:
PASD1 Expression in Malaysian Hematological Malignancies Patients
Authors: Johdi Nor Adzimah , Mohd Said Hanif Zulkhairi , Jamal Rahman , Mohd Idris Mohd Razif , Ismail Nor Azimah , Wan Jamaludin Wan Fariza , Abd Wahid S. Fadila , Mustangin Muaatamarulain , Tizen Laim Nur Maya Sabrina 
Published: April 2022

Per ARNT SIM domain containing 1 (PASD1) protein belongs to the Cancer Testis Antigen (CTA) family. It shows restricted expression in normal tissues but are highly expressed in cancer tissues. This study aims to further investigate PASD1 expression in Malaysian hematological malignancies patients as a potential biomarker for disease progression and vaccine development. Formalin-fixed Paraffin-Embedded (FFPE) tissue specimens from hematological malignancies patients were labeled with anti-PASD1-1 and anti-PASD1-2 antibodies using immunohistochemistry method. Our results show that among DLBCL patients, 7 samples were positive for PASD1-1, 2 samples were positive for PASD1-2 while 3 samples were positive for both of the antibodies. In addition, only 1 sample from T-cell Lymphoblastic Lymphoma (TLL) showed positive staining with PASD1-1. Other classes of hematological malignancies did not show any positive staining with either antibody. Antibody PASD1-1 stained the membrane and cytoplasm of the tumor cells strongly. Moderate nuclear labeling was also observed in some cases of DLBCL with PASD1-2. PASD1-1 staining was more frequent compared to PASD1-2 in most of the samples. Positive PASD1 staining was observed in patients with age range between 36-71 years old, higher in male cases than female by 54% and higher in Malay patients compared to Chinese by 77%. Due to its frequency, the PASD1_v1 protein may play a role in the DLBCL initiation and progression. A higher number of PASD1 staining in DLBCL samples compared to other lymphoma subtypes may suggest that PASD1 may represent a potential for DLBCL subtyping marker.
LA IMPORTANCIA DE LA PUBLICIDAD BTL EN LA ESTRATEGIA DE MARKETING DE LAS EMPRESAS, APLICADO EN EL ESTUDIO DE MERCADOS DE LAS FIBRAS CAPILARES CON MINOXIDIL
Authors: Grajales Mantilla Javier Leonardo , Paul Quintero Jaime Augusto , Velásquez Julián Andrés 
Published: April 2022

La Publicidad BTL (Below The Line), es un concepto muy utilizado en el sector publicitario por las empresas para promocionar sus productos y/o servicios y que sean consumidos por los usuarios.
Implementar una estrategia de publicidad BTL, permite alcanzar los objetivos propuestos por la empresa y con la inteligencia artificial, se espera revolucionar el paradigma actual del marketing, hoy en dia muchas empresas han innovado en sus campañas estas estrategias para puntuarse en el mercado.
Con este proyecto se pretende identificar las estrategias de marketing que permitan posicionar en el mercado a las fibras capilares con minoxidil, un producto que busca contribuir a mejorar la calidad de vida de todas aquellas personas que presentan síntomas de alopecia u otra enfermedad relacionada con la pérdida de cabello, dándoles una solución inmediata. El propósito es generar un valor agregado a todas aquellas personas que han sufrido de pérdida de cabello a causa de diversos factores, ya sea ambientales (fricción natural, exposición al agua y radiación ultravioleta), cosméticos (cepillado, tintes) o hereditarios.
EMPRENDIMIENTO RETO EN LA REACTIVACION ECONOMICA
Authors: Patarroyo Mora Edith 
Published: April 2022

El impacto de la crisis sanitaria en el mundo se hizo sentir con fuerza durante el año 2020 y las expectativas para el 2021 no han llenado las expectativas, ya que el proceso de recuperación ha sido muy lento.
El gobierno busca retomar la agenda prepandemia y para ello debe estimular el emprendimiento de manera convincente, con apoyos financieros y realmente motivantes para el emprendedor, dándoles una oportunidad de recuperación esencial de hombres y mujeres comprometidos en un emprendimiento en crecimiento y no sólo de supervivencia. Con equidad para todos, dado que el emprendimiento se sustenta en la creatividad, las nuevas ideas, la motivación de intereses hacia el desarrollo personal y social, la puesta en escena de oportunidades para todos y como consecuencia las posibilidades de inclusión laboral y, luego si, la reactivación económica del país a través del pago de los impuestos de manera justa y coherente con esa reactivación.
La academia en sus procesos formación intenta fortalecer y crear expectativas en sus estudiantes y egresados sobre la importancia de gestar empresas, no obstante, la realidad en el momento de ejecutoria es muy lenta y las condiciones para acceder a los apoyos financieros y de asesoría para la consolidación de un emprendimiento son bastante complejas, por no decir desestimulantes, eventos muy conocidos por la sociedad colombina en general.
Numerical Investigation of Frequency Reconfigurable Antenna with Liquid Metamaterials for X-band
Authors: Patel Shobhit K. , Bui Cong Danh , Nguyen Truong Khang , Parmar Juveriya , Ngo Quang Minh 
Published: April 2022

In this paper, a frequency reconfigurable liquid metamaterial microstrip-based radiating structure is proposed and it is an attempt toward achieving reconfiguration in liquid metamaterial-based microstrip radiating structures. Reconfigurable antenna design is superstrated with five liquid metamaterial layers based on a distilled water split-ring resonator. Superstrate layers give enhancement from 6.5 dB to 13.1 dB in gain of the proposed antenna. A patch is reconfigured through PIN diodes as RF switches. Switching ‘on’ and ‘off’ states of PIN diodes are used for reconfiguration of frequency and radiation patterns. Analysis in terms of reflection coefficient, gain (dBi), radiation pattern, bandwidth (BW), and half-power beamwidth (HPBW) is obtained in switch-off and switch-on state. The proposed design provides enhanced gain, reflection coefficient, and multiband characteristics in the 8-12 GHz range suitable for X-band satellite and radar applications. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.
Kedalaman Pengerukan Kolam Dermaga TPI Palang Berdasarkan Chart Datum IHO
Authors: Ardiansyah Wisnu , Mahardika Agus , Spanton Perdana Ixbal , Joesidawati Marita Ika 
Published: April 2022

Penentuan chart datum dengan menggunakan komponen pasang surut dapat digunakan untuk menentukan kedalaman kolam dermaga. Kolam dermaga TPI Palang sering digunakan sebagai tempat tambat labuh kapal perikanan, tetapi sering terjadi kapal tersebut kandas sebelum masuk dermaga. Jenis kapal perikanan yang ada di lokasi kolam dermaga TPI Palang adalah kapal payang dengan draf kapal sedalam 2 m. Kedalaman hasil pengukuran kolam dermaga pada bulan Juli 2017 sebesar 8 m. sedangkan kedalaman berdasarkan peta batimetri sebesar 12 m. Perairan Palang Kabupaten Tuban terdapat di laut utara Jawa Timur merupakan jenis perairan terbuka maka penentuan kedalaman dermaga ditentukan berdasarkan keadaan perairan adalah 1,2 x draf kapal yaitu 2,4 m. Metode metode least square dan metode admiralty digunakan untuk membandingkan metode terbaik dalam perhitungan komponen pasang surut Data pasang surut yang digunakan adalah Agustus 2016- Juli 2017 yang diperoleh dari BIG. Tipe pasang surut Perairan Palang adalah diurnal, dengan nilai F untuk pengolahan dengan admiralty sebesar 5.160 dengan pengolahan least square sebesar 5.167. Koefisian korelasi komponen pasang surut dengan pengolahan admiralty terjadi pada K1-MS4 sebesar 0.792, sedangkan dengan least square terjadi pada K1-M4 sebesar 1,6. Hasil perhitungan komponen pasang surut dari least square digunakan untuk menentukan nilai chart datum. Chart datum IHO (International Hidrographic Organization) yang dijadikan sebagai referensi dasar perhitungan kedalaman kolam dermaga TPI Palang. Hasil menunjukkan bahwa kedalaman yang dibutuhkan perairan Palang dalam kondisi eksisting (8 m) masih membutuhkan pengerukan antara 0,033 - 1, 071 m. Namun untuk memenuhi standar kolam dermaga maka kedalaman yang dibutuhkan sebesar 13,071 m (dari LWS) sampai 13,557 m (dari LLWS) yang berarti pengerukan kolam dermaga antara ± 4.
VALIDASI SOAL BERBASIS STEM (SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS) UNTUK CALON GURU BIOLOGI
Authors: Seftia Ifa 
Published: April 2022

Tujuan dari penelitian ini yaitu untuk mengembangkan soal-soal berbasis STEM untuk mahasiswa sehingga dikategorikan sebagai penelitian pengembangan (R & D). Produk penelitian ini ditujukan untuk mahasiswa Pendidikan Biologi Universitas PGRI Ronggolawe Tuban (UNIROW) angkatan 2017. Waktu penelitian dimulai bulan April tahun 2020 sampai dengan bulan Juli tahun 2020. Model pengembangan Dick and Carey dipilih sebagai desain penelitian ini. Desain penelitian pengembangan Dick and Carey terdiri dari 7 langkah pelaksanaan strategi penelitian dan pengembangan. Desain penelitian ini digunakan karena lebih spesifik dalam pengembangannya. Pada tahap awal penelitian dilaksanakan research yaitu tahapan penelitian atau studi literatur untuk mendapatkan informasi tentang kebutuhan produk yang akan dikembangkan. Tahap pengembangan yang digunakan terdiri dari sepuluh tahapan yaitu (1) analisis kebutuhan, (2) analisis bentuk soal berbasis STEM, (3) analisis materi dengan keterampilan yang ingin dicapai, (4) merumuskan tujuan pencapaian keterampilan, (5) mengembangkan soal berbasis STEM, (6) validasi soal berbasis STEM, (7) revisi soal berbasis STEM. Produk ini belum diujicobakan secara luas karena terhambat pandemi Covid-19. Soal-soal berbasis STEM yang dikembangkan berupa soal esai yang terdiri dari soal Pretest, soal Latihan, dan soal Posttest. Setiap soal menunjukkan salah satu profil kemampuan STEM. Berdasarkan hasil validasi dapat diketahui bahwa semua aspek penilaian mendapatkan kriteria sangat baik. Aspek yang mendapatkan persentase skor tertinggi adalah aspek kesesuaian isi dengan persentase skor sebesar 84,38 %. Sedangkan aspek yang mendapatkan persentase skor terendah adalah aspek kegrafikan dengan persentase skor sebesar 82,14 %. Aspek kebahasaan mendapatkan persentase skor sebesar 82,50 %.
Analogy: the universal switch of Schopenhauerian thought
Authors: Batini Ugo 
Published: April 2022

Often perceived by its contradictors as the main fragility of its system, analogy constitutes however a driving element of the development of Schopenhauerian metaphysics, and makes it possible to avoid the pitfall of theoretical egoism in which any idealistic philosophy can sink. We will try to show, in accordance with the indications of paragraph 19 of The World as Will and Representation, how Schopenhauer understands the totality of the phenomena "by analogy with our body" and establishes the structure of his masterpiece from this analogical dynamic that puts in motion the primitive intuition of his thought.
Tetraspanin co029 expression as a tumor biomarker for monoclonal antibodies preparation: antigenic assessment in colorectal cancer cells
Authors: Coutinho Lucelia , Corsini Camila , Assis Jessica , Pedrosa Maria Luysa , Jeremias Wander , Santos Viviane , Cabral Monica , Mesquita Ana Sofia , Viviani Matheus , Nogueira-Rodrigues Angelica , Grenfell Rafaella 
Published: April 2022

ABSTRACT
Introduction: The identification of innovative cancer biomarkers is a very relevant ongoing quest. Moreover, their role in cancer diagnosis and clinical management has been radically changed in the last few years with the major emphasis on cancer molecular classification, therapeutic target identification, and therapeutic protocol responsivity. tetraspanins are a family of transmembrane proteins correlated with tumor stage, tumor type and patient outcome affecting cell growth, morphology, invasion, and metastasis.
Methods: We expressed the 31kDa transmembrane human tetraspanin co029 antigen in Escherichia coli expression host cells using Gateway® platform. Western blotting and ELISA techniques, together with gene sequencing, confirmed the identity of TSP co029 recombinant protein. Forty clones producing antibodies against TSP co029 were obtained. These antibodies were incubated with human colorectal cancer cells in different conditions. ELISA and immunohistochemistry were also performed.
Results: The expressed tetraspanin had an appropriate conformation and antigenic integrity to produce antibodies with affinity to the native TSP co029 biomarker. The affinity of the purified recombinant protein and antibodies were confirmed by western blotting, florescent staining of human colorectal cancer cells in fluorescence and confocal microscopies and by ELISA and immunohistochemistry.
Conclusion: Our data showed that the recombinant protein and antibodies produced in this study allowed the confirmation of tetraspanin co029 protein presented on the surface of human colorectal cancer cells.
Percepción discente de una materia matemática
Authors: Delgado Pineda M. , Reviriego Batres A. 
Published: April 2022

Este trabajo es un complemento discente a la memoria académica de la experiencia evaluadora desarrollada en la asignatura, Lenguaje Matemático, Conjuntos y Números, del grado de Matemáticas en el curso 2020-21 del grado de Matemáticas de la Universidad Nacional de educación a Distancia, UNED. En la Enseñanza No Presencial ocurre que la forma de evaluar condiciona la forma de estudiar de muchos estudiantes y esto se particulariza en la opinión de un estudiante que se vio afectado por ese sistema experimental de evaluación. También se recoge en este trabajo las creencia personales del estudiante sobre la enseñanza actual y las ideas personales de lo que es aprenden Matemáticas. Estas reflexiones son fruto de una interiorización personal que le han permitido evolucionar desde la autoformación hacia la cooperación en el marco de la enseñanza a distancia.
Abstract
This work contains a student complement to the academic memory of the evaluation experience developed in the subject, Mathematical Language, Sets and Numbers, of the degree of Mathematics in the course 2020-21 of the degree of Mathematics of the National University of Distance Education, UNED. In non face-to-face teaching, it happens that the way of evaluating conditions the way of studying of many students, and this is particularly reflected in the opinion of a student who was affected by this experimental evaluation system. This work also includes the student's personal beliefs about current teaching and personal ideas about what it is to learn Mathematics. These reflections are the result of a personal internalization that has allowed him to evolve from self-training to cooperation within the framework of distance learning.
Auditoria interna como ferramenta de gestão para as empresas
Authors: Batista Junior Juarez Vilela , Paula Anderson Nery da Silva de , Silva Anderson Santos da 
Published: April 2022

Com todas as mudanças que ocorrem no mundo corporativo devido a globalização e a competitividade que está cada vez maior, é de suma importância que os administradores busquem ferramentas que sejam capazes de auxiliar no controle das organizações. Por conta disso, a atividade de auditoria interna passou a fazer parte das empresas modernas. Dessa forma, o objetivo geral do trabalho foi compreender as contribuições da auditoria interna como ferramenta de apoio para à gestão empresarial. A metodologia utilizada no presente trabalho compreendeu em uma Revisão Bibliográfica sobre o tema proposto, no qual essa foi dividida em três capítulos: primeiro se explicou a evolução, definição e tipos da auditoria contábil, em seguida se descreveu os procedimentos da auditoria interna nas empresas, por fim se caracterizou as contribuições da auditoria interna para à gestão empresarial. Nos tempos modernos a auditoria passou a ser uma ferramenta de suma importância que deve ser usada pela governança empresarial como um instrumento de controle. Sendo assim, a implantação de uma auditoria interna contribui para que a organização possa identificar erros ou fraudes reduzindo o risco financeiro e operacional. Por meio dos relatórios que são elaborados pela auditoria é que os administradores passam a ter informações tempestivas, integras e que sejam mais confiáveis para o processo decisório.
Effects of Temperature and Variety on Rehydration Parameters and Solute Loss during Soaking of Omakwa and Abrohemaa Maize Varieties
Authors: Antwi Isaac Godfred , Addo Ahmad , Bart-Plange Ato 
Published: April 2022

This study was carried out to investigate the effects of soaking temperature and variety on the rehydration parameters and solute loss (essential minerals and vitamin C) of two maize varieties.
Sun-dried kernels of the maize varieties (Omakwa and Abrohemaa) were soaked at four different water temperatures of 30oC, 40oC, 50oC and 60oC in a thermostatic water bath and the rehydration parameters determined. Temperature and variety were the two principal factors found to influence water uptake by the kernels. The highest rehydration ratio of 13.28 and 14.65 for Omakwa and Abrohemaa respectively occurred at the highest soaking temperature of 60oC. The quantitative analysis of solute loss (phosphorus, sodium, potassium and vitamin C) carried out reveals that large amounts of Potassium and vitamin C leached into the soaking water at higher water temperatures while residual amount of sodium saw an initial increase before decreasing to a low value as the temperature increases. For phosphorus, larger residual amounts were obtained at low to moderate soaking temperatures while a further increase in soaking temperature beyond 50oC resulted in a decrease. Soaking at temperatures of 40oC and 50oC were found to retain more nutrients hence moderate temperature of 40oC ≤X≤ 50oC may be considered for soaking of Omakwa and Abrohemaa maize varieties.
Mechanism of Antagonistic Bioagents in Controlling Root-Knot Nematodes (Meloidogyne sp.): A Review
Authors: Afriyie Boakye Thomas , Kwadwo Anning Dominic , Li Huixia , Osei Richard , Boamah Solomon , Anim Samuel 
Published: April 2022

Root-knot nematodes are among the most significant pathogenic organisms due to their global distribution, capacity for destruction, and economic importance. Antagonistic bioagents are more effective alternative to synthetic pesticides in the suppression of root-knot nematodes. Bioagents reduce the use of synthetic chemicals, which are hazardous to both humans and the environment. Despite this, some bioagents, such as fungi and bacteria have unknown mechanisms. This review discusses the nematophagous bacteria and fungi that have been discovered so far, including Pochonia, Trichoderma sp., Pseudomonas sp., and Bacillus sp., with an overview of the current advances in research regarding their molecular and biochemical control mechanisms. Biological control agents (BCAs), as valuable ecological enemies of nematode infestations, use a range of mechanisms, such as parasitism, nutrient competition, toxin production, induce systemic resistance to antibiotics, enzymes, and enhance plant health. They suppress nematodes directly, improve plant growth, and facilitate the colonization and activities of antagonistic microbes in the rhizosphere. Understanding the molecular basis of BCAs suppression mechanisms provides the basis for their future incorporation into phytopathogen or plant disease control management. This study reviews the current threat posed by the root-knot nematode, biological control, antagonistic bioagents, and their mechanisms, and the future perspectives in modern agricultural sustainability to provide basis for the broad control of root-knot nematodes.
Impact Analysis of Education in Emergency (EiE): A Case of Wangduechhoeling Lower Secondary School, Bhutan
Authors: Jamtsho . 
Published: April 2022

This paper closely examines the impact of Education in Emergency (EiE) amid the pandemic in Wangduechhoeling Lower Secondary School (WLSS), under Bumthang district, Bhutan. The study also tries to look into how each pupil can exercise a right to learn during the pandemic despite their family background. It touches upon several aspects such as learning progress of the students, learning gaps, and its contingency programs. It further highlights how students’ parents would play a parental role in providing spontaneous learning space and time. And this case study assesses the effectiveness of the implementing EiE programs in the school.
Using the central limit theorem (CLT), we analyzed the data from 30 percent of the population (180 students and 90 parents). The findings of the study revealed that most students had responded that online learning was effective. 94.4 percent of the students responded that learning through EiE was effective, and 88.8 percent of the students enjoy EiE lessons. However, 36.6 percent of the students responded that they faced difficulty in using different learning forums. 96.6 percent of the students had textbooks with them, 81.1 percent of teachers assessed tasks given through Television, Radio, Self-Instructional Materials (SIM) lessons. The findings also indicated that 81.6 percent of the parents had been supportive in their children’s learning. Due to emergence of COVID-19 pandemic and the consequent closure of the school, 57.7 percent of students’ interest towards learning was affected. On other hand, the study depicted that 97.7 percent of students were excited to return to school as and when reopens. In addition, the study revealed that while 64 percent of the students had availed 60 percent special data packages discount, 55.7 percent of them had not availed it.
PENDAMPINGAN TIM ABDIMAS UNIVERSITAS CIPUTRA DALAM PELAKSANAAN VAKSINASI MASSAL DI KELURAHAN PUTAT JAYA KOTA SURABAYA
Authors: Yuwono Natalia , Sutanto J.E. , Tambunan Damelina Basauli 
Published: April 2022

Tujuan dari kegiatan pengabdian kepada masyarakat ini adalah Tim pelaksanaan dari Universitas Ciputra Surabaya, akan memberikan bantuan pada salah satu kelurahan di Kota Surabaya yang terkategori termasuk dalam daftar 10 besar kelurahan dengan kasus covid 19 terbanyak di Surabaya, sehingga diharapkan khususnya bagi warga atau masyarakat di RW 03 Kelurahan Putra Jaya bisa terbantu secara signifikan dalam penanganan dampak covid -19 tersebut. Dalam program kegiatan yang dilaksanakan yaitu awalnya sudah menjadi kebutuhan di lapangan, sehingga pihak Tim pelaksana pengabdian kepada masyarakat dari Universitas Ciputra Surabaya beserta Tim Satgas yang dibentuk bersama dan sekaligus yang akan mewakili kegiatan pelaksanaan kegiatan pengabdian kepada masyarakat di RW 03 Kelurahan Putat Jaya. Beberapa program yang diberikan kepada warga atau masyarakat RW 03 Kelurahan Putat Jaya antara lain: memberikan bantuan berupa tabung oksigen dan pelatihan mengoperasionalkan peralatan yang terhubung dengan tabung oksigen kepada Tim Satgas, memberikan APD dan obat-obatan, membantu mensosialisasikan program kegiatan termasuk pembuatan dan pemasangan poster di lingkungan RW 03 Kelurahan Putat Jaya, serta pendampingan pelaksanaan vaksin khususnya bagi warga atau masyarakat setempat. Adapun hasil yang telah dicapai ialah ditunjukkan dengan data perkembangan bagi warga membuktikan bahwa banyak yang sembuh setelah melakukan vaksin. Dengan demikian, adanya kerjasama antara Tim Pelaksana dari Universitas Ciputra Surabaya dengan Tim Satgas dari Kelurahan Putat Jaya yang sudah berjalan dengan baik, tentunya harapan kita semua program kegiatan pengabdian kepada masyarakat tersebut ini sangat membantu dan bermanfaat bagi khususnya warga atau masyarakat RW 03 Kelurahan Putat Jaya dan sekaligus bagi warga dan masyarakat Kota Surabaya.