bluuebunny/crossref_metadata_2025_split huggingface dataset:
Irisin, a mediator of muscle crosstalk with other organs: from metabolism regulation to protective and regenerative effects
Authors: Momenzadeh Sedigheh , Jami Mohammad-Saeid , Jalalvand Amirmasoud , Esfarjani Fahimeh , Shahabi Shirin , Zamani Saeed 
Published: February 2022

Abstract:
Physical exercise is a therapeutic strategy for some systemic and non-systemic complications. Various processes or factors like myokines are involved in an exercise course. Irisin is produced in skeletal muscle during exercise, and its effects resemble many exercise effects. Besides the systemic effects of muscle-derived irisin, this peptide is produced in different tissues.
Numerous studies have investigated the underlying molecular mechanisms of irisin effects. Despite some controversies, most studies have demonstrated the improvement of metabolic-related complications and immunomodulatory or regenerative mechanisms in correlation with the circulating level of this peptide or after in vivo/in vitro treatments that have introduced it as a peptide with therapeutic value.
This review describes the similarities and differences of the effects in various tissues and their correlation with the most prevalent tissue-related complication to present a view for the mechanism(s) of function, efficacy, and safety of this peptide in each tissue as an exercise effector and endocrine peptide.
Review of post-translational modification of human serum albumin
Authors: Kannan Surya , Souchelnytskyi Serhiy 
Published: February 2022

Abstract:
Post-translational modifications (PTMs) may affect functions of human serum albumin. Here we review reports of novel PTMs of human serum albumin. One hundred twenty-three recently reported novel O-phosphorylation, glycation, methylation, carbonylation, and acetylation of albumin are reviewed. Potential impact of these PTMs on albumin functions is discussed. Knowledge of these PTMs of albumin is of importance for use of albumin in medical applications, e.g., in transfusion, drug formulations and remedies.
Vitamin D Levels in Patients with Behcet's Disease: A Systematic Review
and Meta-Analysis
Authors: Kheradmand Hamid Reza , Hashemzadeh Kamila , Rezazadeh Maryam , Eftekhari Abolfazl , Esparham Ali , Jokar Mohammad Hassan 
Published: February 2022

Objective:
Behcet’s disease (BD) is a chronic multisystem inflammatory disease classi-fied as Variable Vessel Vasculitis with unclear etiology. We designed this systematic review and meta-analysis to evaluate vitamin D status in Behcet’s disease patients with this background.

Methods:
We performed this systematic review and meta-analysis according to PRISMA guide-lines. We included all observational studies in humans published in English, evaluating the associa-tion of 25(OH)D concentrations in Behcet’s patients. Two reviewers (HRK and AE) independently searched the databases and screened articles based on their titles and abstracts. A third reviewer re-solved all disagreements. We performed analysis using Cochrane Program Review Manager Ver-sion 5.3. The protocol for this review was registered on PROSPERO (CRD42020197426).

Results:
A total of 341 publications were initially identified according to the search strategy. Final-ly, 12 publications were included in the meta-analysis. We performed this meta-analysis on 1265 participants from different studies with a sample size ranging from 63 to 224 individuals. In studies comparing active and inactive subgroups of patients with Behcet’s disease, we found a significantly lower serum level of vitamin D in patients with Active BD (-0.4; 95 % CI: -0.61, -0.25; p<0.001). We found that the serum level of vitamin D in Behcet’s disease is significantly higher than in health controls (0.5; 95 % CI: 0.15, 0.50; p=0.001).

Conclusion:
We demonstrated that the existing evidence is consistent with the hypothesis that an increased serum level of vitamin D would be associated with substantially lower risk of active Behcet’s disease.
A Review on Analytical Method Development for the Estimation of a Potent
Muscarinic Receptor Antagonist Tolterodine Tartrate
Authors: Chakraborty Atyurmila , Acharjya Sasmita Kumari , Dash Sanat Kumar , Tripathy Satyanarayan , Sahoo Mitali , Tripathy Bimala 
Published: February 2022

Background:
A pharmaceutical will be clinically accepted if it is impurity-free and its
dose is accurately maintained. For this, the contribution of analytical techniques for developing
and validating a new pharmaceutical dosage form cannot be overlooked.

Introduction:
Tolterodine tartrate is a potent competitive muscarinic receptor antagonist. It binds
to the muscarinic M3 receptors in the bladder selectively and competitively. It is used to treat urinary
incontinence and overactive bladder syndrome. The 5-hydroxymethyl derivative is the
pharmacologically active metabolite of Tolterodine tartrate, which is as potent as the main drug.
It is available with α-adrenergic blocker Tamsulosin in combined pharmaceutical formulations,
treating benign prostatic hyperplasia in men. This review article presents several analytical methods,
including HPLC, HPTLC, UV-Visible spectrophotometry, spectrofluorimetry, electroanalytical,
and various hyphenated techniques like GC-MS, LC-MS, LC-MS-MS, etc., for estimation of
Tolterodine tartrate is present as a single material or in combined form in bulk materials, different
pharmaceutical formulations, and biological matrices.

Conclusion:
HPLC and spectrophotometry are the most widely used methods for determining the
drug in the bulk and pharmaceutical dosage form among all these methods. LC-MS and LC-MSMS
are widely used for the estimation of Tolterodine tartrate from plasma and other biological
fluids. All the methods included in this article are accurate, sensitive, and cost-effective.
The Promise of CAR T-Cell Therapy for the Treatment of Cancer Stem
Cells: A Short Review
Authors: Poondla Naresh , Sheykhhasan Mohsen , Akbari Mohammad , Samadi Pouria , Kalhor Naser , Manoochehri Hamed 
Published: February 2022

Abstract:
Chimeric antigen receptor (CAR) T-cell therapy is a type of sophisticated tailored immunotherapy
used to treat a variety of tumors. Immunotherapy works by utilizing the body's own immune system
to discover and destroy malignant cells. In CAR-T therapy, a patient’s own immune cells are genetically
engineered to recognize and attack cancer. Treatments employing CAR T-cells are currently showing
promising therapeutic results in patients with hematologic malignancies, and their safety and feasibility
in solid tumors have been verified. In this review, we will discuss in detail the likelihood that CAR Tcells
inhibit cancer stem cells (CSCs) by selectively targeting their cell surface markers will ultimately
improve the therapeutic response for patients with various forms of cancer. This review addresses the
major components of cancer stem cell (CSC)-targeted CAR T-cells against malignancies, from bench to
bedside.
Recent Advances in Synthesis and Anticancer Potential of Triazole-Containing
Scaffolds
Authors: Bhagat Devidas S. , Bumbrah Gurvinder S. , Chawla Pooja A. , Gurnule Wasudeo B. , Shejul Sampada K. 
Published: February 2022

Abstract:
Cancer is the most lethal disease that may be found anywhere globally. Approximately 10% of individuals
die due to cancer of various types, with 19.3 million new cancer cases and 10 million deaths reported in 2020. More
than 100 medications are commercially available for the treatment of cancer, but only a few candidates have high specificity,
resulting in several side effects. The scientific community has spent the past decades focusing on drug discovery.
Natural resources are used to isolate pharmaceutically active candidates, which are then synthesized in laboratories.
More than 60% of all prescribed drugs are made from natural ingredients. Unique five-membered heteroaromatic
center motifs with sulfur, oxygen and nitrogen atoms are found in heterocyclic compounds, such as indazole, thiazole,
triazole, triazole, and oxazole, and are used as a core scaffold in many medicinally important therapies. Triazole possesses
a wide range of pharmacological activities, including anticancer, antibacterial, antifungal, antibiotic, antiviral,
analgesic, anti-inflammatory, anti-HIV, antidiabetic, and antiprotozoal activities. Novel triazole motifs with a variety
of biological characteristics have been successfully synthesized using versatile synthetic methods. We intend here to
facilitate the rational design and development of innovative triazole-based anti-cancer medicines with increased selectivity
for various cancer cell lines by providing insight into various ligand-receptor interactions.
Front-End Survivability in Wireless Optical Broadband Access Network
Authors: Solanki Sangita , Upadhyay Raksha , Bhatt Uma Rathore 
Published: February 2022

Background:
Survivability is the one of the key issue of wireless optical broadband (WOBAN) access network. Survivability means to provide continuous services to users if a device/link failure occurs in the network

Objective:
The component link failure can occur in the network due to any reason. In this condition huge data loss will occur in the network.

Methods:
In this paper, we consider the front-end survivability in WOBAN. We propose a novel maximum protection minimum link cost routing algorithm (MPMLC) that provides path protection with minimum link cost to front-end of the WOBAN. The proposed MPMLC algorithm assigns weight/cost to wireless link using link state prediction (LSP).

Results:
The path with minimum cost is selected to route the traffic (actual/affected due to failure) of front end network. The proposed algorithm outperforms in terms of reduced network delay and wireless link cost

Conclusion:
It is also observed from simulation results that when the multiple link failures occur in the network, proposed MPMLC algorithm exhibit better results in terms of reduced wireless link cost as compared to existing algorithm.
Pengaruh otonomi kerja terhadap turnover intention melalui mediator pemberdayaan psikologis pada karyawan pertelevisian
Authors: Akbar Iqbal Bahtiyar , Hasanati Nida , Shohib Mohammad 
Published: February 2022

ABSTRACT Turnover Intention is an important phenomenon that affects the development of the company. One of the factors that influence turnover intention is work autonomy. High work autonomy will increase psychological empowerment, ultimately affecting turnover intention. The purpose of this study is to determine the effect of work autonomy on turnover intention through mediators of psychological empowerment. This research approach uses a quantitative approach. The method of data collection uses the scale of The Work Design Questionnaire, the Multidimentional questionnaire of Psychological Empowerment and Mobley's Measurement Model. Determination of the sample using purposive sampling technique, the total subject is 72 people from four local television companies in Malang, Data analysis using Bootstrapping analysis. The results obtained are (1) There is no effect of work autonomy on turnover intention, the value of F = 2.748 (p = 0.102); (2) There is an influence of work autonomy on psychological empowerment with a value of F = 47.07 (p = 0,0001); (3) There is no effect of psychological empowerment on turnover intention, F value = 0.654 (p = 0.421); (4) There is no mediating effect of psychological empowerment on work autonomy with turnover intention.KEYWORDS Turnover Intention, Work Autonomy, Psychology EmpowermetCITITATION Akbar, I., Hasanati, N., & Shohib, M. (2019). Pengaruh Otonomi Kerja Terhadap Turnover Intention Melalui Mediator Pemberdayaan Psikologi Pada Karyawan Pertelevisian. Jurnal Online Psikologi, 7, (3), X-X.
Model pemrosesan informasi pada intensitas perilaku hate speech pengguna media sosial
Authors: Fajriyah Nidaan , Hudaniah Hudaniah , Prasetyaningrum Susanti 
Published: February 2022

The intensity of hate speech behavior is the level of one’s activities in showing negative evaluations as well as justifying and spreading hatred upon others. The rising number of cases of hate speech, bullying, racism, and so on in social media, made researchers interested in conducting research on how students’ strategies in processing information obtained on social media. This study aims to determine the intensity of hate speech behavior by social media users on the selection of information processing strategies or messages on social media. This research incorporates a descriptive quantitative research model. The subjects of this study amounted to 158 people age 19-25 years who were selected using the accidental sampling technique. The research instruments in the present study are the information processing scale and hate speech behavior scale. The results showed that social media users in this study tended to use heuristic processing types (61%), systematic (35%), and systematic-heuristic (3%) which demonstrate that most social media users tended to think simply about the content of any information in social media.
PENGEMBANGAN PTERIDISC POKOK BAHASAN PTERIDOPHYTA SEBAGAI MEDIA PEMBELAJARAN TAKSONOMI TUMBUHAN
Authors: Nurlia Anna , Hariyadi Bambang , Muswita Muswita 
Published: February 2022

Standards learning competency plant taxonomy is, students can understand and explain the principles of classification, description, identification, nomenclature, and knowing the morphological and anatomical structure of plants. Students can achieve competence learning if the student successfully mastered the material plant taxonomy. The absence of appropriate learning media to optimize students' understanding of the taxonomy of plant material can cause difficulties or obstacles for students to understand the material plant taxonomy. Therefore, the development of instructional media in the form of Pteridisc needs to be done. The purpose of this study was to determine the end product of learning media Pteridisc on the subject of Pteridophyta and to determine the response students of Biology Education PMIPA FKIP University of jambi to use as a learning medium Pteridisc plant taxonomy. Based on the results obtained validation, assessment for each indicator on the design aspects of the media were on both criteria with the average percentage of 75%, and ratings for the indicators on the material aspects of the media are on the criterion of good and very good, with a mean percentage of 86, 7%. Student responses to assessment of each indicator in the trial against the use of a small group of media currently on the criteria very well with the average of the responses given percentage 94.23%, and student responses to assessment of each indicator in a large group trials are in very good criteria with the average percentage of 87.82%. It can be concluded that the instructional media products Pteridisc subject Pteridophyta included in the criteria very well, so it can be used by the student in learning activities. Keywords: development, instructional media, taxonomy Pteridophyta
PENGEMBANGAN MEDIA PEMBELAJARAN KOLEKSI AWETAN CANGKANG GASTROPODA UNTUK KELAS X SMA
Authors: Syafitri Rauda , Hamidah Afreni 
Published: February 2022

ABSTRACT The purpose of this research is to develop a product that form of a collection gastropods shell preserved that can be used as a learning media both theoretical and practical work at class x senior high school. The product is a collection of learning media preserved shell of gastropod which has three parts, namely the wardrobe collection, collection boxes and shelves collection. This type of research is ADDIE development model. The results showed the revised product media experts, subject matter experts and trial of respondents is as follows. Media validation is performed three times. At the first validation obtained a percentage of 50.7% and categorized not good. The second validation obtained percentage of 65.3% and is average, and the third validation obtained a percentage of 76% categorized as good and media can be used to trial. Then, validation matter is done four times. At the first validation obtained a percentage of 29.3% and classified is not very good. At the second validation obtained a percentage of 65.3% and is average. At the third validation obtained a percentage of 82.7% and good categorized. At the fourth validation obtained by percentage of 88% categorized as very good. After validated and revisions, the product tested on small groups and obtained the students' response was 91% with a very good category. Learning media of collection gastropods shell preserved feasible for use in the learning process. Key word: media learning , a collection of gastropod shells preserved development
Prototipe Alat Transmisi Data menggunakan Gelombang Cahaya berbasis Arduino
Authors: Kurniawati Endah , Basuki Agung Yoke 
Published: February 2022

Pada era pandemi saat ini perkembangan teknologi sangat dibutuhkan pada bidang telekomunikasi. Hal ini terjadi karena adanya social distancing, adanya kondisi yang diharuskan untuk tidak menyentuh barang – barang yang ada disekitar untuk kesehatan kita sehingga kemudahan untuk berkomunikasi secara wireless dimanapun dan kapanpun sudah menjadi faktor utama bagi konsumen pengguna jasa telekomunikasi, begitu juga dengan kualitas dalam penggunaannya Hampir semua hal dilakukan atau dikerjakan melalui internet bahkan sistem pembelajaran Sekolah Dasar hingga Perguruan Tinggi dilakukan dengan sistem pembelajaran online atau daring, sehingga komunikasi data dilakukan hampir setiap saat dan setiap tempat. Wi-Fi (Wireless Fidelity) hampir digunakan disetiap gedung, pertokoan, hunian dan sebagainya.. Light Fidelity atau Li-Fi merupakan teknologi terbaru yang akan menggantikan Wi-Fi (Wireless Fidelity). Teknologi ini disebut VLC (Visible Light Communication) yaitu sistem komunikasi nirkabel yang menyampaikan informasi dengan memodulasi cahaya yang terlihat oleh mata manusia. Secara teoritis cahaya lampu dari jenis LED (Light Emitting Dioda) bisa digunakan sebagai media transmisi untuk kecepatan tinggi. Sementara itu pengunaan LED saat ini hanya diaplikasikan sebagai lampu penerangan. Metode yang digunakan dalam penelitian ini adalah metode penelitian eksperimental. Sistem kendali alat transmisi pada penelitian ini dirancang menggunakan Arduino sebagai pusat kendali dari sistem. Dari Hasil pengujian LED RGB yang digunakan pada sistem ini dengan jarak 60 cm sebanyak 20 buah dapat bekerja sesuai yang dibutuhkan. Pada pengujian komunikasi membutuhkan waktu kurang dari 1 detik. Dalam pengiriman sinyal pada prototipe ini terdapat bit error rate sistem sebesar 25% hingga 75%, namun tidak mempengaruhi proses lainnya.
Perancangan Kendali Jarak Jauh Alat Bantu Pernapasan (Ventilator) Memanfaatkan Lora Dalam Menghadapi Pandemic Covid-19
Authors: Alkaff Jafar Sodiq 
Published: February 2022

Sebuah fenomena dibidang kesehatan dunia sedang terjadi akibat dari virus yang menyerang pada fungsi vital dari kehidupan manusia, yaitu fungsi pernapasan. Virus ini dinamakan Corona Virus yang merupakan keluarga besar virus yang menyebabkan penyakit mulai dari gejala ringan sampai berat. Coronavirus Disease 2019 (COVID-19) adalah penyakit jenis baru yang belum pernah diidentifikasi sebelumnya pada manusia. Virus penyebab COVID-19 ini dinamakan Sars-CoV-2. WHO mendorong setiap negara didunia kedokteran untuk membuat dan mengembangkan alat ventilator, khususnya Ventilator Emergency. Pemerintah mengintruksikan ke Kementerian Kesehatan R.I. melalui Instansi Balai Pengamanan Fasilitas Kesehatan (BPFK) Jakarta untuk melakukan pengujian terhadap ventilator tersebut. Dengan memanfaatkan sistem gerak motor servo, dan pengontrolan menggunakan mikrokontroler Arduino, maka dapat dibuat miniatur Ventilator Ambubag, yang bisa digunakan sebagai pertolongan pertama dalam penanganan pasien COVID-19 ini. Dari hasil pengujian didapatkan nilai error Breath Rate / Respiratory Rate (RR) 3%, Inspiratory dan Expiratory Time Ratio (I : E Ratio) 6%, dan Tidal Volume (TV) >10%. Dan untuk menghindari penularan virus akibat dari pengendalian ventilator ini, digunakan remote control atau pengendalian dari jarak jauh sejauh 20m dengan NLOS (Non Line Of Sight).
Perangkat Uji Penciuman sebagai Protokol Kesehatan Menggunakan Fuzzy Mamdani Berbasis Internet Of Things
Authors: Dani Akhmad Wahyu , Mundhola Ahmad , Rahmatullah Rizky , Mundhofa Ahmad 
Published: February 2022

Penerapan protokol kesehatan terhadap pandemi Corona Virus Disease 2019 (Covid-19) di tempat umum dapat dilakukan dengan tes identifikasi bau berdasarkan penilaian fungsi indera penciuman. Penelitian ini bertujuan untuk merancang prototipe alat uji indera penciuman yang bekerja secara otomatis sebagai wahana protokol kesehatan Covid-19 dan mengetahui pengaruh kontrol fuzzy Mamdani terhadap kinerja perangkat dalam mengelola pengujian aroma. Prototipe dirancang di Badan Pengkajian dan Penerapan Teknologi (BPPT) menggunakan uji identifikasi bau dengan memberikan pengujian 5 jenis aroma secara acak yang dihasilkan oleh odor generator penghasil aroma. Generator aroma dilengkapi dengan kendali fuzzy Mamdani sebagai pengontrol PWM kecepatan kipas yang digunakan dalam menghembuskan gas aroma, dengan parameter masukan himpunan fuzzy sensor jarak dan sensor pendeteksi gas Volatile Organic Compounds (VOC). Pengujian tersebut didasarkan pada skor tes penciuman dari identifikasi setiap responden dengan total skor maksimal 5 pada identifikasi aroma yang sempurna. Hasil uji indra penciuman untuk setiap responden dikirim ke server yang terintegrasi dengan platform IoT ThingsBoard dan dikirim kepada setiap responden yang melakukan pengujian. Berdasarkan hasil pengujian fungsi prototipe, nilai keluaran PWM hasil perhitungan fuzzy Mamdani mikrokontroler Arduino memiliki akurasi sebesar 99,70% berdasarkan perbandingan simulasi di Matlab. Kendali fuzzy Mamdani dapat meningkatkan persentase rata-rata skor jawaban benar pada tes indra penciuman sebesar 14% terhadap 3 responden dan hasil tes dapat dikirim ke email akun ThingsBoard untuk setiap pengguna yang terdaftar pada sistem.
The Nonlinear Relation between Effective Tax Rates and Tax-Related Restatements
Authors: Cheng Christine , Hennes Karen M. , Sapkota Pradeep 
Published: February 2022

SYNOPSIS
We examine the association between firms' tax planning behavior, as measured by their effective tax rates (ETRs), and financial restatements. We find that both low and high ETRs are positively related to subsequent tax-related restatements, indicating a nonlinear relation between ETRs and tax-related financial reporting quality. We also find evidence that tax-related restatements for low ETR firms reflect increased operational complexity that pervades the firm and results in an increased likelihood of tax and non-tax restatements. High ETR firms, in contrast, appear to suffer from inadequate controls and expertise surrounding the reporting for income taxes. We do not find evidence that this extends outside the tax function to other types of restatements. All results hold after controlling for internal control weaknesses and other characteristics known to affect ETRs and the likelihood of restatements.
Data Availability: Data are available from public sources identified in the text.
Robotic Process Automation: A Literature-Based Research Agenda
Authors: Plattfaut Ralf , Borghoff Vincent 
Published: February 2022

ABSTRACT
Robotic Process Automation (RPA) is a relatively new approach to automate business processes in organizations. Practitioners have adopted it extensively, notably within the accounting discipline; however, the scientific research seems to be lagging. As a result of this, there is no clear definition or uniform understanding of the advantages and disadvantages of RPA. To close this gap, we conducted a structured and systematic literature review of published scholarly articles on RPA. We set out to identify the definition of RPA, consider its feasibility regarding implementation, outline the advantages and disadvantages, and evaluate the risks and best practices of RPA. In this paper, we show that the literature has particularly failed to discuss the quantifiable benefits of RPA. The best practices identified are especially relevant for practitioners. Based on our findings, we propose an agenda for future research on RPA.