bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aging and dental health (middle age versus geriatric age)
Authors: Heta Saimir , Robo Ilma , Haxhiu Eva , Resuli Jona , Rumano Blerta , Kapaj Sonila , Ostreni Vera 
Published: September 2022

Abstract
Background: Aging as a physiological process has attracted the attention of many authors in publication of data about physiological and pathological changes that occur in organism. This study aims to express the latest data in literature about dental changes that occur as a result of aging, at component structures of oral cavity, associated with results in numbers of dental changes, comparing middle age and geriatric age.The study presents data recorded from the patients included in this study, about dental status and about systemic condition and systemic pathologies that patients suffer from. Data were recorded at different times, including a total of 93 patients. After clinical examination, endodontically treated teeth were initially recorded. The data about prosthetic treatment were recorded, divided into categories of partial or total prosthetic treatment. The systemic diseases from which patients suffer were recorded.Results: 78% of patients have natural teeth in oral cavity. The range of 16-25 teeth in oral cavity, i.e. 50-78% of mouth filled with natural teeth, includes 22% of patients: 5% of pre-geriatric age and 17% of geriatric age. Edentulism is present in status at level of 22%, while the lack of endo treatment is 39% even in clinical cases where deep caries was present in oral cavity. The presence in 78% of clinical cases with natural teeth is associated with 61% of these same cases of endodontic treatment. Fixed prosthesis is presented in 84% of clinical cases included in the study, while removable prosthesis, regardless of whether it is total or partial, is presented in 61% of clinical cases of the study.Conclusions: The comparison of middle age and geriatric age about collected dental data leads to results that clearly speak about the tendency for prosthetic replacements with both fixed prosthesis and removable prosthesis, placing emphasis the role of dental status at the whole organism. The significant increase in percentage of endodontically treated teeth is another value that speaks of the population's awareness of dental care. The presence of natural teeth, expressed in numbers and percentages, is a value that reflects data on dental care over the years.
Caffeic Acid attenuates acrylamide induced biochemical, hematological and histological alterations in rats
Authors: Gupta Divya , Shrivastava Sadhana , Gupte Shamli S. , Shukla Sangeeta 
Published: September 2022

Abstract
Acrylamide is formed during processing of food at high temperature and is documented as a well-known neurotoxic, carcinogenic and has many adverse effects on human health. Therefore, it is the need of hour to reduce the detrimental effect of acrylamide. In the present sub-chronic study 18 adult Wistar rats were randomly divided into three groups. These groups were normal saline, toxicant, and toxicant (19.13 mg/kg) + therapy (20 mg/kg). Our result showed all the sign and symptoms of acrylamide toxicity which include reduction in the body weight, hind limb splaying, hair loss and skin irritation. A significant alteration in the hematological parameters and sharp enhancement in AST, ALT, ALP, LDH, GGT, urea, uric acid and triglycerides was recorded. Activity of acetylcholinesterase significantly reduced in brain after acrylamide administration. Acrylamide exposure resulted into increased mean DNA damage and tail length in liver, kidney and brain as compared to normal evident by COMET assay. Our biochemical findings were reinforced by histological observation. Treatment with caffeic acid restored tissue and serological indices accompanying towards normal.
The Differences among Full Sternotomy, Partial Sternotomy, and Right Infra-axillary Thoracotomy with Stonehenge Technique for Aortic Valve Surgery
Authors: Tashima Yasushi , Fujita Ryo , Sano Taichi , Nakamura Noriyuki , Adachi Koichi , Kimura Naoyuki , Yamaguchi Atsushi 
Published: September 2022

Abstract
Background: The surgical outcomes of trans-right axillary aortic valve replacement (AVR) with Stonehenge technique (SHAVR), which involves in pulling the heart closer to the right chest wall with retraction sutures of the pericardium to improve the surgical view, remains unknown although the partial sternotomy (PAVR) is widely recognized as a minimally invasive approach for AVR. We evaluated the surgical outcomes of the respective approaches compared to the conventional approach (CAVR).Methods: A retrospective analysis of 137 consecutive patients who underwent isolated and initial AVR was performed at our institution between January 2009 and December 2020. After matching propensity scores with preoperative characteristics, surgical outcomes were compared between the two groups (PAVR vs. CAVR: n = 22 each, SHAVR vs. CAVR: n = 28 each). Results: The SHAVR group did not show any significant differences in operative time, aortic cross-clamp time, CPB time, postoperative complications, and hospital death compared with the CAVR group. The length of hospital stay was likely to be shorter in the SHAVR group and the PAVR group than in the CAVR group (P = 0.043, P = 0.047). However, in the PAVR group, operative time, aortic cross-clamp time, and CPB time were significantly longer than in the CAVR group (P = 0.029, P = 0.015, P = 0.003), although there were no significant differences in postoperative complications and hospital death. Based on Multivariate risk analysis, PAVR (in comparison to SHAVR) was an independent risk factor for more than 2 hours of prolonged CPB time (P = 0.034).Conclusion: These findings suggest that SHAVR can be a safe technique and has cosmetic benefits and a faster CPB time than PAVR.
Clinical prediction model for pulmonary embolism diagnosis in hospitalized patients with SARS-CoV-2 infection
Authors: Franco-Moreno A. , Brown-Lavalle D. , Rodríguez-Ramírez N. , Muñoz-Roldán C. , Rubio-Aguilera AI. , Campos-Arenas M. , Muñoz-Rivas N. , Moya-Mateo E. , Ruiz-Giardín JM. , Pardo-Guimerá V. , Ulla-Anes M. , Pedrero-Tomé R. , Torres-Macho J. , Bustamante-Fermosel A. 
Published: September 2022

Abstract
Background: We aimed to develop a clinical prediction model for pulmonary embolism (PE) diagnosis in hospitalized COVID-19 patients. Methods: Hospitalized non-intensive care unit COVID-19 patients who underwent a computed tomography pulmonary angiogram for suspected PE were included. Demographic, clinical, laboratory and radiological variables were selected as potential factors associated with the presence of PE. Multivariable Cox regression analysis to develop a score for estimating the pretest probability of PE was used. The score was internally validated by bootstrap analysis.Results: Among the 271 patients who underwent a computed tomography pulmonary angiogram, 132 patients (48.70%) had PE. Heart rate >100 bpm (OR 4.63 [95% CI 2.30–9.34]; p<0.001), respiratory rate >22 bpm (OR 5.21 [95% CI 2.00–13.54]; p<0.001), RALE score ≥4 (OR 3.24 [95% CI 1.66–6.32]; p<0.001), C-reactive protein  >100 mg/L (OR 2.10 [95% CI 0.95–4.63]; p = 0.067), and D-dimer >3.000 ng/mL (OR 6.86 [95% CI 3.54–13.28]; p<0.001) at the time of suspected pulmonary thrombosis were independent predictors of PE. Using these variables, we constructed a nomogram (CHEDDAR score [C-reactive protein, HEart rate, D-Dimer, RALE score, and Respiratory rate]) for estimating the pretest probability of PE in an individual patient. The score showed a high predictive ability (AUC 0.877; 95% CI: 0.83−0.92). A score lower than 182 points on the nomogram confers low probability of PE with a negative predictive value of 92%. Conclusions: CHEDDAR score can be used to estimate the pretest probability of PE in hospitalized COVID-19 patients outside intensive care unit.
Engineering of Hole Transporting Interface by Incorporating the Atomic-Precision Ag6 Nanoclusters for High-Efficiency Blue Perovskite Light-Emitting Diodes
Authors: Bai Xue , Zhang Fujun , Gao Yanbo , Lu Po , Zhong Yuan , Liu Yue , Bao Xinyu , Xu Zehua , Lu Min , Wu Yanjie , Chen Ping , Hu Junhua , Zhang Yu , Wu Zhennan , Song Hongwei 
Published: September 2022

Abstract
The property of the underlying hole transport layer (HTL) plays a crucial role in determining the optoelectronic performance of perovskite light-emitting devices (PeLEDs), as their governing abilities in carrier injection and charge transport. However, endowing the current HTL system with a deep highest occupied molecular (HOMO) level concurrent with high hole mobility is still a big challenge, in particular being an open constraint toward high-efficiency blue (range of 460–495 nm) PeLEDs. In this regard, employing the traditional HTL material of poly(9-vinylcarbazole) (PVK) as a model, we perform efficient incorporation of the atomic-precision metal nanoclusters (NCs), [Ag6PL6, PL = (S)-4-Phenylthiazolidine-2-thione], to achieve significant tailoring in both of HOMO energy level (from − 5.8 eV to -5.94 eV) and hole mobility from (2.5×10− 5 to 2.34×10− 4 cm2 V− 1 s− 1), thus realizing the flat-band injection of holes between HTL and emitting layer and a strengthened ability in hole transport. As a result, the as-modified PeLEDs exhibit an external quantum efficiency (EQE) of 12.02% at 488 nm, which is around 1.3 times higher than that of the control device, i.e., 9.48%. The presented study exemplifies the success of metal NCs involved in HTL engineering by deepening the concept of the metallic molecule, and offers a simple while an effective additive strategy to settle the blue PeLEDs HTL dilemma, which paves the way for the fabrication of highly efficient blue PeLEDs.
Circulating Th17 T Cells at Treatment Onset Predict Autoimmune Toxicity of PI3Kδ Inhibitors
Authors: Gadi Deepti , Martindale Stephen , Chiu Pui , Khalsa Jasneet , Chen Pei-Hsuan , Fernandes Stacey , Wang Zixu , Tyekucheva Svitlana , Machado John-Hanson , Fisher David , Armand Philippe , Davids Matthew , Rodig Scott , Sherry Barbara , Brown Jennifer 
Published: September 2022

Abstract
PI3Kδ inhibitors are approved for the therapy of B cell malignancies, but their clinical use has been limited by unpredictable autoimmune toxicity, despite promising efficacy and evidence that toxicity is associated with improved clinical outcomes. Prior phenotypic evaluation by CyTOF has identified increases in activated CD8 T cells with activation of Th17 T cells, as well as decreases in Tregs, particularly in patients with toxicity. Here we sought to further understand the effects of idelalisib and duvelisib in vitro, and demonstrate that both idelalisib and duvelisib can inhibit T cell proliferation as well as Th1 and Treg differentiation in vitro, while promoting Th2 and Th17 differentiation. We further demonstrate directly using intracellular flow cytometry that autoimmune toxicity in patients is associated with higher absolute numbers of CD4 and CD8 T cells with Th17 differentiation in peripheral blood prior to therapy, and that gastrointestinal tissues from patients with active autoimmune complications of PI3Kδ inhibitors show infiltration with Th17 + T cells. These same tissues show depletion of Tregs as compared to CLL patients without toxicity, suggesting that loss of Tregs may be permissive for Th17 activation to lead to autoimmune toxicity. Clinical trials to restore this balance are warranted.
Sonographic characteristics of diffuse sclerosing variant of papillary thyroid carcinoma with histopathological correlation: a preliminary study
Authors: Li Wanying , Wang Ying , Gao Luying , Feng Ruie , Lv Ke , Wu Xining , Yang Xiao , Li Jianchu , Cai Sheng , Wang Hongyan 
Published: September 2022

Abstract
Background: Diffuse sclerosing variant of papillary thyroid carcinoma (DSVPTC) is a rare but high invasive subtype of papillary thyroid carcinoma, which mandates an aggressive clinical strategy. Few studies have focused on the sonographic characteristics of DSVPTC and the role of ultrasound in diagnosis and treatment of this variant remains unknown. This study aimed to identify and understand DSVPTC more accurately under ultrasound in correlation with pathology.Methods: The ultrasound characteristics and histopathologic sections of 10 lesions in 10 DSVPTC patients who underwent thyroid surgery at our center between 2014 and 2020 were reviewed and compared with 184 lesions in 168 classic variant of papillary thyroid carcinoma (cPTC) patients.Results: 6 DSVPTC cases (60%) showed the “snowstorm” pattern on sonogram and 4 cases (40%) presented hypoechoic solid nodules only. Vague borders (100.0% vs. 18.5%, P=0.019) and abundant microcalcifications (66.7% vs. 10.9%, P=0.037) were more common in DSVPTC nodules than in cPTC nodules, corresponding to the infiltrating boundaries and numerous psammoma bodies under the microscope respectively. Most of the DSVPTC cases had a heterogeneous background (80%) and suspicious metastatic cervical lymph nodes (80%) on sonograms. All DSVPTC cases had histopathological metastatic cervical lymph nodes.Conclusion: The sonographic “snowstorm” pattern indicated DSVPTC with whole-lobe occupation. Hypoechoic solid nodules with vague borders and abundant microcalcifications on sonogram suggested DSVPTC lesion with an ongoing invasion. Regardless of which of the two sonograms was shown, the corresponding DSVPTC lesions were aggressive and required the same attention from the surgeons.
Association between Time-Updated Eosinophil Counts and Progression of CKD
Authors: Hattori Kohki , Sakaguchi Yusuke , Oka Tatsufumi , Kawaoka Takayuki , Kajimoto Sachio , Asahina Yuta , Matsui Isao , Mizui Masayuki , Kaimori Jun-Ya , Isaka Yoshitaka 
Published: September 2022

Abstract
Patients with chronic kidney disease (CKD) have high blood eosinophil count but its clinical implication is uncertain. Since eosinophils may induce tubulointerstitial injury and arteriosclerosis, eosinophilia might be related to poor clinical outcomes. This retrospective cohort study included 2,877 patients whose estimated glomerular filtration rate (eGFR) was 10–60 mL/min/1.73 m2. The exposure was time-updated blood eosinophil counts. The outcomes were 1) initiation of renal replacement therapy (RRT) and 2) cardiovascular events and mortality. We analyzed the associations between eosinophil counts and outcomes using marginal structural models (MSM). Over a median follow-up of 6.5 years, eosinophil counts were measured a median of 22 times per patient (4 times a year per patient). There was a negative correlation between eosinophil count and eGFR. In total, 433 patients initiated RRT, 275 developed cardiovascular events, and 165 died. In MSM, higher eosinophil counts (≥ 289/µL) showed a 1.83-fold (95% confidence interval:1.33–2.51) higher rate of RRT initiation than lower eosinophil counts after adjustment for time-dependent confounders. Higher eosinophil counts were also associated with a higher rate of cardiovascular events and mortality in MSM (hazard ratio, 1.71 [95% confidence interval:1.30–2.25]). In conclusion, patients with CKD who had higher eosinophil counts showed worse kidney outcome.
Dielectric, Thermal, and Electrical Conductivity Properties of Biodegradable Polymer Nanocomposites
Authors: Abdelhamid Hani Nasser 
Published: September 2022

Abstract
Biodegradable polymers exhibit shortcomings, including low thermal stability and electrical conductivity. These challenges limit the broad applications of several applications, such as electronic devices. They show suitable dielectric, thermal, and electrical conductivity compared to the biodegradable polymer alone. Several methods can improve biodegradable polymers' dielectric, thermal, and electric conductivity, including co-polymerization, blending, and cross-linking with other polymers. Furthermore, the formation of nanocomposites seems to be the most effective method to improve the properties and performance of biodegradable polymers. This book chapter summarized biodegradable polymers' dielectric, thermal, and electrical conductivity. Biodegradable polymers nanocomposites consisting of polymers blend, inorganic, and other nanomaterials were discussed.
Occurrence, fate, and ecological risk assessment of Endocrine disrupting chemicals in sewerage drains and sewage treatment plant
Authors: Puri Mehak , Gandhi Kavita , Kashyap Sanjay M. , Kumar M. Suresh 
Published: September 2022

Abstract
In the present work, wastewater treatment plant and sewerage drains from Nagpur, Central India were studied for frequently occurring endocrine disrupting chemicals (EDCs). All the EDCs, such as bisphenol A (BPA), butylparaben (BuP), and diethyl phthalate (DEP) were present in all the collected samples with a detection frequency of 100%. Laboratory analysis revealed high BPA, BuP, and DEP levels, with mean concentrations of 79.10 ng/L, 4.12 ng/L, and 2.25 µg/L, respectively, in influent samples and 33.20 ng/L, 1.62 ng/L, and 0.77 µg/L, respectively, in effluent wastewater. The distribution of the emergent pollutants among the sampling locations was found to be consistent with the physico-chemical characteristics of wastewater, according to the component analysis, and the sites with the highest levels of contamination were also identified. Finally, an ecological risk assessment was carried out for aquatic biota in terms of risk quotients (RQs). The RQs for the target chemicals in effluent wastewater suggested a minimal impact, except for the target insect Chrironomus riparius, which had an RQ value of 33.20 for BPA.
Low energy availability reduces bone mass and gonadal function in male mice
Authors: Ito Eri , Sato Yuiko , Kobayashi Tami , Soma Tomoya , Matsumoto Tatsuaki , Kimura Atushi , Miyamoto Kana , Matsumoto Hideo , Matsumoto Morio , Nakamura Masaya , Sato Kazuki , Miyamoto Takeshi 
Published: September 2022

Abstract
In women, the female athlete triad, marked by low energy availability, functional hypothalamic amenorrhea and osteoporosis, is a recognized risk for stress fractures. Stress injuries also occur in men, but by contrast risks and mechanisms underlying them are less characterized. Here we propose that low energy availability puts men at risk for stress injuries as well. Male low energy availability model mice, established by limiting food intake, exhibited significantly reduced testicle weight, serum testosterone levels and bone mass. Such losses in bone mass were enhanced by exercise in food-restricted (FR) male mice. Histological analysis revealed that both bone-resorbing and -forming activities were significantly reduced in FR or FR plus exercise (FR+ex) mice, mimicking a state of low bone turnover. Significantly reduced bone mass in FR or FR+ex male mice was significantly rescued by treatment with 1,25(OH)2D3 (1.25) or ED71 (ED), both active vitamin D analogues, with significant restoration of osteoblastic activities. Serum levels of insulin-like growth factor I (IGF-I), which activates osteoblastic activities and is critical for bone remodeling, were significantly lower in FR versus control male mice, but restored by administration of either of vitamin D analogue. However, administration of recombinant IGF-I did not rescue reduced bone mass in FR male mice, and administration of either active vitamin D analogue could increase bone mass even in IGF-I conditional knockout FR male mice. Taken together, conditions comparable to the female athlete triad are also a risk for male stress injuries, and low energy availability is upstream of gonadal dysfunction and osteoporosis in males. Active vitamin D analogues could serve as therapeutic or preventive options for stress injuries in men.
Radiative cooling wrapping films with controlled hierarchical porous structures
Authors: Park Choyeon , Park Chanil , Park Sungmin , Choi Jae-Hak , Kim Yong Seok , Yoo Youngjae 
Published: September 2022

Abstract
Current research has focused on effective solutions to mitigate global warming and the accelerating greenhouse gas emissions. Compared to most cooling methods requiring energy and resources, passive daytime radiative cooling (PDRC) technology offers excellent energy savings as it requires no energy consumption. However, existing PDRC materials encounter unprecedented problems such as complex structures, low flexibility, and performance degradation after stretching. Thus, this study reports a porous structured thermoplastic polyurethane (TPU) film with bimodal pores to produce high-efficiency PDRC with efficient solar scattering using a simple process. The TPU film exhibited an adequately high solar reflectivity of 0.93 and an emissivity of 0.90 in the atmospheric window to achieve an ambient cooling of 5.6°C at midday under a solar intensity of 800 W/m2. Thus, the highly elastic and flexible TPU film was extremely suitable for application on objects with complex shapes. The radiative cooling performance of 3D-printed models covered with these TPU films demonstrated their superior indoor cooling efficiency compared to commercial white paint (8.76°C). Thus, the proposed design of high-efficiency PDRC materials is applicable in various urban infrastructural objects such as buildings and vehicles.
Long-Term Effects in Structures: background and recent developments
Authors: Harapin Alen , Jurišić Marino , Bebek Neda , Sunara Marina 
Published: September 2022

AbstractThe article presents overview of selected long-term effects in civil-engineering structures. Those effects are usually neglected in standard engineering practice, but in some cases can be very important for mechanical resistance and safety of the structures. Main aspects of these phenomena are discussed, with three illustrative examples which accentuated why is important to take them into account.
WITHDRAWN: High-frequency of twin-embryo seeds with clonal and sexually produced embryos drives apomixis in hybrid rice
Authors: Junhao Dan , Xia Yumei , Zhan Yijie , Zhang Longhui , Tang Ning , Wang Yao , Tian Junyou , Deng Huafeng , Cao Mengliang 
Published: September 2022

Abstract
Heterosis is a common phenomenon in biology, and fixation of heterosis can be achieved via artificially induced apomixis. Sundaresan's team used mitosis instead of meiosis (MiMe) rice mutants that ectopically expressed BBM1 in egg cells to induce the production of clonal seeds. In this study, we ectopically expressed BBM1 in MiMe mutants, and 62.50% of the seeds produced by Yongyou 4949 hybrid rice were clonal. More importantly, a high frequency of twin seedlings (33.56%) was detected. Moreover, a low frequency (1.41%) of twin seedlings was obtained only when BBM1 was ectopically expressed, and no twin seedlings were found when the genome of the MiMe mutant was edited. These findings suggest that the high frequency of twin seedlings resulted from the ectopic expression of BBM1 combined with MiMe. The embryo sacs of the twin seedlings were removed and subjected to cytological observations. One sperm combined with the polar nucleus to develop into the endosperm, and the other sperm combined with the egg cell to form a zygotic embryo. Moreover, a synergid cell near the egg cell developed into an embryo through apogamy, thus resulting in the formation of two embryos. The results showed that AtDD45-driven BBM1 could induce synergid cells to develop into embryos autonomously through normal fertilization of egg cells, resulting in the formation of twin seedlings. This study provides a theoretical reference and new ideas for research on apomixis in hybrid rice and is important for promoting the fixation of heterosis of hybrid rice.
On the generalized Lambert transform over Lebesgue and Boehmian spaces
Authors: Maan Jeetendrasingh , Negrin E.R. , Gonzalez B. J. 
Published: September 2022

Abstract
In this paper we study the generalized Lambert transform introduced by Raina and Srivastava (Rev. Tecn. Fac. Ingr. Univ. Zulia, 18(3), 301-304, 1995) over Lebesgue spaces. We also extend this transform to Boehmian spaces.