bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apparent Diffusion Coefficient and Its Standard Deviation from Diffusion-weighted Imaging to Differentiate Tumor-adjacent and Tumor-distant liver tissues in T3 staged Resectable Gallbladder Carcinoma
Authors: Tang Zhao , Wu Yu-ping , Tan Bang-guo , Chen Xiao-qian , Guo Wen-wen , Zhou Chuanqinyuan , Xu Min , Wu Ke-shan , Zhang Xiao-ming , Chen Tian-wu , Zhou Hai-ying 
Published: November 2022

Abstract
Background
An extended cholecystectomy is generally recommended for patients with gallbladder carcinoma (GBC) at stage T2 or above, and involves cholecystectomy and a limited hepatic resection. It is important to differentiate tumor-adjacent and tumor-distant liver tissues before surgery for surgical strategies decision making. Diffusion-weighted imaging (DWI) can provide functional information by depicting the diffusion of water in biological tissue and can be quantitated by apparent diffusion coefficient (ADC). Our study aimed to evaluate feasibility of ADC and its standard deviation (ADCsd) to differentiate between tumor-adjacent and tumor-distant liver tissues in T3 staged resectable GBC.
Methods
A total of 41 consecutive patients with T3 staged resectable GBC were included in this retrospective study and divided into two sets with (n = 27) and without (n = 14) liver invasion. All patients underwent DWI at b-values of 0, 20, 50, 80, 100, 200, 400, 600, 800 and 1000 sec/mm2 with a 3.0-T magnetic resonance scanner before surgery. Mean ADC and ADCsd of tumor-adjacent and tumor-distant liver tissues were measured on DWI, and were compared by Mann-Whitney U tests. If there was a significant difference in any derived parameter, area under the receiver operating characteristic curve (AUC) was used to assess performance of this parameter for differentiating tumor-adjacent and tumor-distant liver tissues.
Results
In the set with liver invasion, mean ADC and ADCsd of tumor-adjacent liver tissue were lower than those of tumor-distant liver tissue when b = 0, 800 sec/mm2, and b = 0, 1000 sec/mm2, respectively (all P-values < 0.05). In the set without liver invasion, ADC and ADCsd at all b values had no statistical differences between tumor-adjacent and tumor-distant liver tissues (all P-values > 0.05). To differentiate tumor-adjacent from tumor-distant liver tissues in the set with liver invasion, AUCs of ADC were 0.687 (b = 0, 800 sec/mm2) and 0.680 (b = 0, 1000 sec/mm2), respectively; and those of ADCsd were 0.673 (b = 0, 800 sec/mm2) and 0.731 (b = 0, 1000 sec/mm2), respectively.
Conclusions
In patients with liver invasion by T3 staged GBC, ADC and ADCsd could have potential value in differentiating tumor-adjacent from tumor-distant liver tissues.
Plate on Plate Osteosynthesis in Both Bone Forearm With Concomitant Distal End Radius Fracture - a Rare Case Report
Authors: Mahajan Neetin Pralhad , Patil Tushar Chandrakant , GS Prasanna Kumar , Mhatre Jayesh Anant , Pande Kartik Prashant 
Published: November 2022

Abstract
INTRODUCTION :
Distal end radius fractures and both bone forearm fractures are quite common upper limb trauma emergency cases. Management gets complicated when both injuries occur concomitantly in same upper limb.
CASE REPORT :
Here we present a rare case of both bone forearm fracture with ipsilateral distal end radius fracture in a 32 years young male after a high velocity trauma. This case of was managed by 2.7mm volar plate and K wire for DER fracture and 3.5mm DCP in both bone forearm fractures with overlapping plates for 2 fractures of radius. 6 months postoperatively there is adequate fracture union and good functional outcome of wrist and forearm.
CONCLUSION :
The concomitant use of 2.7mm volar LCP for DER fracture and 3.5mm DCP in both bone forearm fractures with overlapping plates for long extended or segmental fractures of radius provides a stable construct with homogeneous stress distribution.
Study on the Regional Difference, Dynamic Evolution and Influencing Factors for China’s Carbon emissions
Authors: Tian Yajuan , Zhang Yuying 
Published: November 2022

Abstract
This paper aims to provide a comprehensive analysis of China’s
carbon emissions evolution from the “10th Five-Year”
Plan period to the “13th Five-Year” Plan period from the
perspectives of “east, center and west” and with multiple methods
and viewpoints, and to vividly display the relationship between
carbon emissions and economic growth with half-parameter method.
Kernel density estimation, quadrantal diagram and box plots were
utilized in this paper to analyze the carbon emissions evolution
process in three major regions in China and various provinces, and
Dagum Gini coefficient and decomposition method were applied to
study the regional difference and source of carbon emissions. Then,
the half-parameter estimation – generalized additive model was
adopted to study the non-linear relationship between carbon
emissions and economic growth. The results showed that the carbon
emissions in entire China and the eastern, central and western
regions grew year after year, but the growth rate decreased. The
carbon emissions evolution processes in the eastern, central and
western regions featured variably; the difference in carbon
emissions expanded in general and inter-regional difference was the
main cause for the general difference, which declined significantly
during the observation. Since 2011, the intensity of
trans-variation has become the major source of the general
difference. The impact of economic growth on carbon emissions
differed in different regions and control variables led to
different carbon emissions effects in different regions. Fully
reviewing the evolution characteristics and laws of carbon
emissions in the three major regions in China, this paper provides
research support for refined and efficient low carbon emissions
policy-making and decision-making reference for realizing the “dual
carbon” objective: “carbon peaking” and “carbon neutralization” in
an all-round way.
A randomized controlled trial evaluating the effects of motivational interviewing in new hearing aid users (MI-HAT): study protocol for a randomized controlled trial
Authors: Liu Alice Q. , Wijesinghe Printha , Lee Melissa , Sun Jane , Lau Carol , Nunez Desmond A. 
Published: November 2022

Abstract
• Background: : Hearing loss is the third leading global cause of disability and is associated with poorer quality of life. Hearing aids are often recommended for hearing loss; however, hearing aid uptake and use rates are perpetually low. Motivational interviewing (MI) is a patient-centered counselling aimed at addressing desire in the patient to change their behaviour. The aim of this study is to investigate the impact of one-on-one MI sessions on hearing aid use among new adult users
• Methods: A multi-center, prospective, randomized patient-blind controlled trial with a pre- and post- tests design. New hearing aid users ≥ 18 years of age will be recruited from Vancouver, Canada. They will be randomly assigned to a treatment or control group. The treatment group will attend a one-on-one MI session hosted by a practicing MI therapist in addition to standard in-person audiological care. The control group will receive standard in-person audiological care. Data is collected at baseline and at 1, 3, 6, and 12 months follow-ups. The primary outcomes are data-logged hearing aid use hours and patient reported outcomes as measured by the International Outcome Inventory for Hearing Aids questionnaire. Associations between intervention and hearing aid use hours, and self-reported outcome measures will be assessed.
• Discussion: This trial is designed to evaluate the efficacy of one-on-one MI in improving hearing aid use in new adult users in the short- and long- terms. Results will contribute to the evidence on whether MI counselling has an effect on hearing aid use and may guide future clinical practices..
• Trial registration: ClinicalTrials.gov. Review Board NCT04673565. Approved: December 17, 2020. https://clinicaltrials.gov/ct2/show/NCT04673565?cond=motivational+interviewing&cntry=CA&draw=2&rank=8
In vivo bioluminescence imaging of natural bacteria via ATP-binding cassette sugar transporter
Authors: Zhang Qian , Song Bin , Yang Yunmin , Xu Yanan , Ji Jian , Cao Wenjun , Lu Jianping , Ding Jiali , Cao Haiting , Chu Binbin , Hong Jiaxu , Wang Houyu , He Yao 
Published: November 2022

AbstractThe existing bioluminescence imaging (BLI) methods only visualize the location of engineered bacteriain vivo, hardly imaging natural bacteria. Herein, we leverage bacteria-specific ATP-binding cassette (ABC) sugar transporters to internalize luciferase and luciferin by hitchhiking them on the unique carbon source of bacteria, i.e., glucose polymers. Compared with bacteria with mutations in ABC sugar transporters, which hardly internalize the constructed BLI probes (i.e., ~ 2% of uptake rate), both Gram-positive bacteria and Gram-negative bacteria could robustly engulf the constructed BLI probes with a high uptake rate of around 50%. Impressively, the developed strategy enablesex vivobioluminescence imaging of human vitreous containing ten kinds of pathogens collected from patients with bacterial endophthalmitis. By using this platform, we further differentiate bacterial and non-bacterial nephritis and colitis in mice, while their chemiluminescence counterparts (e.g., luminol) are unable to distinguish them. The proposed BLI strategy in non-transgenic bacteria without lysing bacteria expands the pool of bioluminescence applications in the microbial diagnostics within the host organism.
WITHDRAWN: The impact of maternal work-family conflict on problem behaviors among preschoolers during the COVID-19 epidemic: A moderated mediation model of maternal anxiety and trait mindfulness
Authors: Song Zhanmei , Huang Jie , Li Rongqi , Yan Jingfeng , Ye Jiayang , Wu Qiaozhen , Wang Hanyue , Sun Xiaonan 
Published: November 2022

Abstract
Background: Work-family conflict (WFC) can increase maternal anxiety and the risk of children’s problem behaviors, but maternal trait mindfulness level moderates this association during the COVID-19 epidemic. While most studies during the epidemic investigated the relationship between WFC and maternal anxiety in developed countries, no studies were found to examine this association in China. Besides, the mediating effects of maternal anxiety and moderating effects of trait mindfulness on the relationship between WFC and preschool children’s problem behaviors are still unclear. So, this study examined the association between mothers’ WFC and preschoolers’ problem behaviors and identified the roles of maternal anxiety as a mediator and trait mindfulness as a moderator during the COVID-19 epidemic.
Methods: In this cross-sectional study, a sample of 1068 Chinese preschoolers and their mothers from coastal cities in southern China were investigated. Data were collected using demographic questionnaires, Carlson’s WFC scale, Ma’s Parenting Anxiety Scale, Goodman’s SDQ Scale, and Brown and Ryan’s Trait Mindfulness Scale. Data were analyzed using SPSS 26.0 and Process 3.3.
Results: WFC had a positive and direct association with problem behaviors in preschoolers (β=0.118, t-value=3.880, p<0.001). WFC also had a positive and direct association with maternal anxiety (β=0.480, t-value=18.034, p<0.001). And maternal anxiety had a positive and direct association with preschoolers’ problem behaviors (β=0.415, t-value=13.584, p<0.001). The mediating effect value of maternal anxiety between WFC and preschoolers’ problem behaviors was 0.199, and the moderating effect value of trait mindfulness between maternal anxiety and preschoolers’ problem behaviors was -0.078.
Conclusions: WFC can be positively associated with preschoolers’ problem behaviors, and maternal anxiety is an important mediator of this association. So, WFC can cause maternal anxiety and lead to more problematic behaviors in children. Therefore, relevant departments should pay attention to this problem and adopt practical strategies to help mothers cope with high levels of work-family conflict, so as to alleviate maternal anxiety and reduce the preschoolers’ problem behaviors. Besides, Maternal anxiety can be positively associated with preschoolers’ problem behaviors, and trait mindfulness is an important moderator of this association. Because trait mindfulness can alleviate the negative effects of maternal anxiety on children, mothers should attend more mindfulness training courses to try to improve their mindfulness level.
Repair of Osteochondral Defects: Efficacy of a tissue-engineered hybrid implant containing both human MSC and human iPSC-cartilaginous particles
Authors: Ando Wataru , Nakagawa Shinichi , Shimomura Kazunori , Hart David , Hanai Hiroto , Jacob George , Chijimatsu Ryota , Yarimitsu Seido , Fujie Hiromichi , Okada Seiji , Tsumaki Noriyuki , Nakamura Norimasa 
Published: November 2022

Abstract
Both mesenchymal stromal cells (MSC) and induced pluripotent stem cells (iPSC) offer the potential for repair of damaged connective tissues. The use of hybrid implants containing both human MSC and iPSC was investigated to assess their combined potential to yield enhanced repair of osteochondral defects. Human iPSC-CP wrapped with tissue engineered constructs (TEC) containing human MSC attained secure defect filling with good integration to adjacent tissue in a rat osteochondral injury model. The presence of living MSC in the hybrid implants was required for effective biphasic osteochondral repair. Thus, the TEC component of such hybrid implants serves several critical functions including, adhesion to the defect site via the matrix and facilitation of the repair via live MSC, as well as enhanced angiogenesis and neovascularization. Based on these encouraging studies, such hybrid implants may offer an effective future intervention for repair of complex osteochondral defects.
Construction of Risk Prediction Model for Hyponatremia in Patients with Acute Decompensated Heart Failure
Authors: Gong Huanhuan , Zhou Ying , Huang Yating , Liao Shengen , Wang Qin 
Published: November 2022

Abstract
Background: Patients with Heart failure（HF）commonly have a water-electrolyte imbalance due to various reasons and mechanisms, and hyponatremia is one of the most common types. However, currently, there are very few local studies on hyponatremia risk assessment in patients with acute decompensated heart failure (ADHF), and there is a lack of specific screening tools. The aim of this study is to identify a prediction model of hyponatremia in patients with acute decompensated heart failure (ADHF) and verify the prediction effect of the model.
Methods: A total of 532 patients with ADHF were enrolled from March 2014 to December 2019. Univariate and multivariate logistic regression analyses were performed to investigate the independently associated risk factors of hyponatremia in patients with ADHF. The prediction model of hyponatremia in patients with ADHF was constructed by R software, and validation of the model was performed using the area under the receiver operating characteristic curve (AUC) and calibration curves.
Results: A total of 65 patients (12.2%) had hyponatremia in patients with ADHF. Multivariate logistic regression analysis demonstrated that NYHA cardiac function classification (NYHA III vs II, OR = 12.31, NYHA IV vs II, OR = 11.55), systolic blood pressure (OR = 0.978), serum urea nitrogen (OR= 1.046) and creatinine (OR = 1.006) were five independent prognostic factors for hyponatremia in patients with ADHF. The AUC was 0.757; The calibration curve was near the ideal curve, which showed that the model can accurately predict the occurrence of hyponatremia in patients with ADHF.
Conclusions: The prediction model constructed in our study has good discrimination and accuracy and can be used to predict the occurrence of hyponatremia in patients with ADHF.
PRPF19 facilitates colorectal cancer liver metastasis through activation of the Src -YAP1 pathway via K63-linked ubiquitination of MYL9
Authors: Zhou Rui , Chen Jie , Jia Jun , Xu Yunxiuxiu , Ye Yibiao , Zhong Guoping , Chen Tao , Lin Qiu 
Published: November 2022

Abstract
Distant metastasis is one of the leading causes of cancer-related mortality of colorectal cancer (CRC). Dysregulation of E3 ubiquitin ligases has been implicated acting vital roles in multiple cancers. In this study, we found that the E3 ubiquitin ligase, PRPF19 was positively correlated with liver metastasis, and predicted a worse clinical outcome in CRC. However, the biological effects and the underlying molecular mechanisms of PRPF19 in CRC remain elusive thus far. We illustrated that PRPF19 promoted the migration and invasion capability of CRC cells in both gain- and loss- of- function assays. Mechanistically, we uncovered that myosin light chain 9 (MYL9) was the downstream substrate of PRPF19. PRPF19 enhanced the stability of MYL9 via K63-linked ubiquitination, and promoted the migration and invasion capability of CRC cells in an MYL9-mediated manner. Furthermore, the Src–YAP1 cascade was identified as the downstream effector mechanism by which the PRPF19/MYL9 axis promoted metastasis in CRC. Taken together, our findings highlighted that the PRPF19/MYL9 axis served as a novel mechanism in CRC metastasis, which provided an attractive therapeutic strategy for CRC treatment.
Outcomes of newly referred patients with suspected angle closure: do we need to redefine the clinical pathways?
Authors: Founti Panayiota , Narayan Akshay , Raja Aneela , Nathwani Neil , Tur Sergio Bordajandi , Thomas Rachel , Scott Andrew , Martins Alessandra , Nolan Winifred 
Published: November 2022

Abstract
Background/Objectives: To investigate outcomes of referrals for suspected angle closure and to explore whether anterior segment optical coherence tomography (AS-OCT) can be used to tighten triaging criteria in a glaucoma virtual clinic.
Subjects/Methods: Retrospectively collected data. The first audit (04/2018-03/2019) identified referrals for suspected angle closure without other glaucoma-related findings (primary angle closure suspect (PACS) referrals). All patients underwent gonioscopy. The second audit (04-08/2019) identified consecutive patients with suspected angle closure in a virtual clinic. Management outcomes were assessed, using gonioscopy as the reference standard. Outcomes were re-audited after changing the triaging criterion from angle width < 10o to iridotrabecular contact (ITC) in ≥1 quadrants on AS-OCT.
Results: Out of 1754 glaucoma referrals (first audit), 24.6% (431/1754) were PACS referrals. Of these, only 10.7% (42/393) had an occludable angle on gonioscopy, with 97.6% (41/42) being PACS. Of these, 78% (32/41) underwent laser peripheral iridotomy. Out of 137 referrals in the virtual clinic (second audit), 66.4% (91/137) were triaged to the face-to-face clinic. Of these, 31.9% (29/91) were discharged. AS-OCT had positive and negative predictive value of 74.3% (95% confidence intervals (CI) 57.8-86.0) and 82.1% (95% CI 70.0%-90.2%), respectively, in detecting ITC in ≥1 quadrants. In the re-audit 45.9% (45/98) of those with suspected angle closure were triaged for gonioscopy, with 24.4% (11/45) of them being discharged.
Conclusion: PACS referrals represent a substantial burden to hospital-based services and their accuracy is low. ITC in ≥1 quadrants on AS-OCT can be useful in triaging those who need further evaluation with gonioscopy.
Association of IL-10–592A/C Polymorphisms With ASCVD: A Systematic Review and Meta-analysis Protocol
Authors: Chai Jie , Cao Xianling , Lu Feng 
Published: November 2022

Abstract
Introduction: Interleukin-10 (IL-10)-592C/A(rs1800872) polymorphism may play a role in the risk of atherosclerotic cardiovascular disease (ASCVD) such as coronary artery disease (CAD) and ischemic stroke (IS).However,the results remained controversial until now.Therefore, we will plan to reanalyze the relativity between IL-10-592C/A single nucleotide polymorphism and ASCVD in a larger clustered population.
Methods and analysis: We search a comprehensive literature by performing on PubMed, Web of Science, Chinese National Knowledge Infrastructure (CNKI) databasesand and Cochrane Library for relevant articles using MeSH terms and related Entry terms (up to 14 Octobor 2022). After removing the duplicates, two reviewers will independently screen the articles for inclusion or exclusion of the study and check titles and abstracts before reading the full text.In addition,the references of the included literature will also be traced to obtain all relevant literature. Newcastle-Ottawa Scale (NOS) will be used to assess methodological quality of studies, a star-rated rating system ranging from 0 to 9 stars.Funnel plot will be used to analyze publication bias. Finally, We will perform a sensitivity analysis on the results of our meta‐analysis to estimate whether our results would be significantly affected by a single included research.
Ethics and dissemination: The article uses secondary data and will not be restricted by ethical approval. The findings will be published by through publications after peers reviewed. All contributors acknowledged that any potential conflict of interest will be declared.
Strengths and limitations:
①This is the first meta-analysis to explore association between IL-10-592A/C polymorphism and ASCVD.
②Gene-gene interactions and gene-environment interactions cannot be ignored, and most eligible studies do not consider these potential effects.Thus, our results may be affected to varying degrees.
③There will be a methodological heterogeneity due to different genetic testing techniques and other techniques were used between different studies
FLRT2 plays a critical role in endothelial cell senescence and vascular aging
Authors: Lee Jae-Seon , Hwang Hyun Jung , Kang Donghee , Kim Jae-Ryong , Choi Jun-Hyuk , Ryu Ji-Kan , Herman Allison B. , Ko Young-Gyu , Park Heon Joo , Gorospe Myriam 
Published: November 2022

Abstract
The roles of fibronectin leucine-rich transmembrane protein 2 (FLRT2) in physiological and pathological processes are poorly known. Here, we identify a novel function of FLRT2 in preventing endothelial cell senescence and vascular aging. We found that FLRT2 expression was lower in cultured senescent endothelial cells as well as in aged rat and human vascular tissues. FLRT2 silencing in human endothelial cells induced senescence through mTORC2, but not mTORC1, AKT, and p53. We uncovered that FLRT2 directly associated with ITGB4 and thereby promoted ITGB4 phosphorylation, while inhibition of ITGB4 significantly mitigated the induction of senescence triggered by FLRT2 depletion. Importantly, FLRT2 silencing in mice promoted vascular aging and overexpression of FLRT2 rescued a premature vascular aging phenotype. We propose that FLRT2 could be targeted therapeutically to prevent senescence-associated vascular aging. Subject terms: FLRT2, ITGB4, mTORC2, endothelial cell senescence, vascular aging