bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reoperations for complications within 90 days after gel stent implantation or trabeculectomy
Authors: Cutolo Carlo A. , Bonzano Chiara , Catti Carlo , Pizzorno Chiara , Bagnis Alessandro , Traverso Carlo E. , Iester Michele 
Published: November 2022

Abstract
Purpose
To describe reoperations in the operating room for complications that occurred within the first 90 days after gel stent implantation or trabeculectomy at a single institution over 5 years.

Methods
In this retrospective chart review, patients who have undergone gel stent implantation with mitomycin C (MMC) or trabeculectomy with MMC were enrolled. Postoperative complications that required reoperations within the first 90 days were evaluated.

Results
A total of 510 surgeries were performed on 392 patients over a 57-month period by 2 glaucoma surgeons. Of these, 284 were gel stent implantation, and 226 were trabeculectomy. Combined phacoemulsification was performed in 52/284 (18.3%) in the gel stent group and in 26/226 (11.5%) of eyes in the trabeculectomy group (p = 0.03). Reoperations took place in 13/510 (2.5%) eyes, including 4/284 (1.4%) in the gel stent group, 9/226 (4.0%) in the trabeculectomy group (p = 0.07). In the gel stent group, indications for reoperation were bleb failure (2), suprachoroidal hemorrhage (1), bullous keratopathy (1). In the trabeculectomy group, indications for reoperation were bleb failure (3), overfiltration (2), persistent wound leak (2), aqueous misdirection (2).

Conclusions
The rates of reoperation for early postoperative complications after gel stent or trabeculectomy was low and comparable with previous studies. A slightly higher number of reoperations within 90 days was observed in the trabeculectomy group than the gel stent group despite the more significant number of combined procedures in the latter group. Bleb failure was the most common indications for reoperation in both groups. Excessive outflow was a cause of reoperation mostly in the trabeculectomy group.
Seasonal and spatial compositional variation of the red algae Mastocarpus stellatus from the Northern coast of Portugal
Authors: Sanz Vanesa , Torres María Dolores , Domínguez Herminia , Pinto Isabel Sousa , Costa Isabel , Guedes A. Catarina 
Published: November 2022

AbstractThis study focusses on the valorization of the red seaweed Mastocarpus stellatus, collected in the Northern coast of Portugal, as a natural source of high value compounds due to its beneficial properties. An annual monitoring of the seaweed was performed by determining its lipids, ash, carbohydrates, phycobiliproteins, total phenolic compounds, antioxidant capacity and carrageenan from three different rocky shores located in the north of Portugal. The results showed a seasonal and spatial variability of the studied compounds between October 2018 and September 2019 depending on the climatic variables of temperature, precipitation, and solar radiation. The most productive season coincided with the warmest months, except for carbohydrates and phycobiliproteins, which were promoted in the colder season. The spatial variation also could be explained by the proximity to water channel discharges at the sampling sites. Complementary studies on the carrageenan fraction were conducted in one of the shores due to the high biopolymer content, to determine their carrageenan proportion between the summer and winter period and establish their rheological capabilities for the formulation of gelling matrices. The extracted biopolymers exhibited typical structural and viscoelastic characteristics of kappa/iota-hybrid carrageenans, suggesting notably differences depending on the harvest season, which is critically relevant to define future applications.
The heterogeneous nature of mechanically accelerated grain growth
Authors: Chen Elton Y. , Hamilton Parker , Boyce Brad L. , Dingreville Rémi 
Published: November 2022

AbstractWhile grain growth is traditionally viewed as a purely thermally driven process, nanocrystalline metals can undergo grain growth under mechanical loads, even at room temperature. We performed a detailed atomistic study of the heterogeneous nature of mechanically accelerated grain growth in a polycrystalline Pt nanowire. Using molecular dynamics simulations, we compared the grain-growth behavior of individual grains during tensile and shear cyclic loading, for three different equivalent strain levels, and at two temperatures. Pure thermal grain growth with no mechanical loading provided a baseline reference case. On average, grains that were already susceptible to thermal grain growth were stimulated to grow faster with mechanical loading, as expected. However, when analyzed on a grain-by-grain basis, the results were far more complex: grains that grew fastest under one stimuli were less accelerated under other stimuli. Even when the magnitude of loading changed, the relative growth of individual grains was distorted. We interpret this complexity from the perspective of superimposed growth mechanisms.
Ethical Conflicts in Healthcare Chaplaincy: Results of an Exploratory Survey Among Protestant Chaplains in Switzerland, Germany, and Austria
Authors: Farr Sebastian , Roser Traugott , Coors Michael 
Published: November 2022

AbstractThe paper reports the results of an exploratory online survey among German, Austrian, and Swiss hospital chaplains (n = 158, response rate 17%) to identify the ethical conflicts they encounter in their work. Respondents indicated that questions surrounding end-of-life care are predominant among the conflicts faced. Chaplains get involved with these conflicts most often through the patients themselves or through nursing staff. Most encounters occur during pastoral care visits rather than in structured forms of ethics consultation such as clinical ethics committees. The results add to the ongoing discussion of chaplains as agents in ethics consultation within healthcare systems as well as their specific role and contribution.
Advancements in the fabrication and characterization of actinide targets for superheavy element production
Authors: Düllmann Ch. E. , Artes E. , Dragoun A. , Haas R. , Jäger E. , Kindler B. , Lommel B. , Mangold K.-M. , Meyer C.-C. , Mokry C. , Munnik F. , Rapps M. , Renisch D. , Runke J. , Seibert A. , Stöckl M. , Thörle-Pospiech P. , Trautmann C. , Trautmann N. , Yakushev A. 
Published: November 2022

AbstractThe heaviest elements can exclusively be produced in actinide-target based nuclear fusion reactions with intense heavy-ion beams. Ever more powerful accelerators deliver beams of continuously increasing intensity, which brings targets of current technology to their limits and beyond. We motivate efforts to produce targets with improved properties, which calls for a better understanding of targets produced by molecular plating, the current standard method. Complementary analytical methods will help shedding more light on their chemical and physical changes in the beam. Special emphasis is devoted to the aspect of the optimum target thickness and the choice of the backing material.
Applications of hydrogels with fire retardant properties—a review
Authors: Mastalska-Popławska Joanna , Wójcik Łukasz , Izak Piotr 
Published: November 2022

AbstractDue to their unique properties, hydrogels can be used in many areas of life and science. The main purpose of this work was to present the possibility of using hydrogels as a kind of fire retardant material itself and as a medium in fire retardant materials used, among others, as the extinguishing agents for fires and the suppression agents for the self-ignition of coal in mines (where their low viscosity and high ability to penetration of the protected material is used), protective layers in fabrics and the so-called robot skin (most often applied in the layer-by-layer system), filling in the fire retardant window panels (mostly hybrid hydrogels or hydrogel copolymers are used) and protective emulsions of the wooden elements used in construction and furniture joinery (mainly in combination with silicate and phosphate derivatives). In the presented applications, hydrogels can be used alone, e.g. due to the large water capacity and at the same time the possibility of dilution, or in combination with fire retardants, what very often allows for the multiplication of the extinguishing or fire retardant effect. Due to the multitude of available studies and the speed of scientific development, this review is focused mainly on publications written after 2015.
Dispersion compensation using cascaded apodized CFBGs under MTDM transmission technique: Enhanced system performance
Authors: Mustafa Fathy M. , Mohamed Asmaa , Khalaf Ashraf A. M. , Sayed Ahmed F. , Aly Moustafa H. 
Published: November 2022

AbstractThis study focuses on compensating chromatic dispersion affecting the propagated signal in a standard single mode optical fibers (SSMFs). We propose a model that consists of an identical four stages cascaded linear chirped apodized fiber Bragg gratings (CFBGs) in a post-compensation scheme under Maximum Time Division Multiplexing (MTDM) technique. MTDM is free of the limitations resulting from the fiber nonlinear effects. It, thus, effectively utilizes optical wavelength and operating in various network of different distances and capacities. Therefore, MTDM is designed to be used in the high-capacity and high-speed transmission systems. The evaluation of the proposed model performance is performed through a comparative study using different connections and the most common apodization functions. This comparative study includes three cases based on the used connection scheme. A 10 Gbps Wavelength Division Multiplexing (WDM) 70 km link is simulated under ordinary operating parameters. Optisystem 7.0 is used for the simulation and evaluation process, in terms of two metrics which are quality factor (Q-factor) and bit error rate (BER). In the pre-compensation scheme, the highest results are: Q-factor = 7.664 and BER = 8.99 × 10–15, using the raised cosine apodization function. Using the raised sine apodization in the post-compensation connection realizes the best performance: Q-factor = 8.58 and BER = 4.77 × 10–18. In the symmetrical-compensation scheme and using the raised sine apodization, the proposed model attains the highest Results: Q-factor = 7.49 and BER = 3.53 × 10–14. The proposed model achieves at least 92.6% improvement in BER and 3.75% in Q-factor over the related works. The study is a simulation work and is performed through Optisystem ver. 7.
Preclinical Considerations for Long-acting Delivery of Tenofovir Alafenamide from Subdermal Implants for HIV Pre-exposure Prophylaxis
Authors: Gunawardana Manjula , Remedios-Chan Mariana , Sanchez Debbie , Fanter Rob , Webster Simon , Webster Paul , Moss John A. , Trinh MyMy , Beliveau Martin , Ramirez Christina M. , Marzinke Mark A. , Kuo Joseph , Gallay Philippe A. , Baum Marc M. 
Published: November 2022

Abstract
Purpose
Long-acting formulations of the potent antiretroviral prodrug tenofovir alafenamide (TAF) hold potential as biomedical HIV prevention modalities. Here, we present a rigorous comparison of three animal models, C57BL/6 J mice, beagle dogs, and merino sheep for evaluating TAF implant pharmacokinetics (PKs).

Methods
Implants delivering TAF over a wide range of controlled release rates were tested in vitro and in mice and dogs. Our existing PK model, supported by an intravenous (IV) dosing dog study, was adapted to analyze mechanistic aspects underlying implant TAF delivery.

Results
TAF in vitro release in the 0.13 to 9.8 mg d−1 range with zero order kinetics were attained. Implants with equivalent fabrication parameters released TAF in mice and sheep at rates that were not statistically different, but were 3 times higher in dogs. When two implants were placed in the same subcutaneous pocket, a two-week creep to Cmax was observed in dogs for systemic drug and metabolite concentrations, but not in mice. Co-modeling IV and TAF implant PK data in dogs led to an apparent TAF bioavailability of 9.6 in the single implant groups (compared to the IV group), but only 1.5 when two implants were placed in the same subcutaneous pocket.

Conclusions
Based on the current results, we recommend using mice and sheep, with macaques as a complementary species, for preclinical TAF implant evaluation with the caveat that our observations may be specific to the implant technology used here. Our report provides fundamental, translatable insights into multispecies TAF delivery via long-acting implants.
Commentary for Special Issue on Using Baseline Target Moderation to Assess Variation in Prevention Impact: When (and How) to Revise Our Programs
Authors: Gardner Frances 
Published: November 2022

AbstractDeveloping a better understanding of sources and mechanisms of heterogeneity is a key route to improving outcomes and targeting of preventive interventions. This commentary attempts to draw together findings from eight intervention trials in this special issue, each exploring baseline target moderation (BTM) or baseline target moderated mediation (BTMM). It considers their implications for prevention research and program design, particularly the question of whether they can help us to revise or adapt interventions. The studies cover a range of interventions, targets, and contexts, including parenting, couple, and CBT interventions, for depression, anxiety, conduct problems, or obesity. Some important findings stand out. Where studies found moderator effects, they tended to operate in a “compensatory” fashion, such that greater benefit was found in higher risk groups, suggesting that closer targeting might be warranted. It was rare for harmful effects to be detected for any subgroups. In other respects, patterns of BTM/BTMM findings were quite mixed across studies, suggesting it would be premature to change our interventions based on these trials. Implications of the findings for equity, for “slimming down” and scaling up interventions, and for research are discussed, including the need to combine BTMM with intervention component research, and to accumulate a more robust body of evidence by pooling data across trials.
Transitions in depression: if, how, and when depressive symptoms return during and after discontinuing antidepressants
Authors: Smit Arnout C. , Snippe Evelien , Bringmann Laura F. , Hoenders H. J. Rogier , Wichers Marieke 
Published: November 2022

Abstract
Purpose
The aim of the current study is to provide insight into if, how, and when meaningful changes occur in individual patients who discontinue antidepressant medication. Agreement between macro-level quantitative symptom data, qualitative ratings, and micro-level Ecological Momentary Assessments is examined.

Methods
During and shortly after antidepressant discontinuation, depressive symptoms and ‘feeling down’ were measured in 56 participants, using the SCL-90 depression subscale weekly (macro-level) for 6 months, and 5 Ecological Momentary Assessments daily (micro-level) for 4 months (30.404 quantitative measurements in total). Qualitative information was also obtained, providing additional information to verify that changes were clinically meaningful.

Results
At the macro-level, an increase in depressive symptoms was found in 58.9% of participants that (a) was statistically reliable, (b) persisted for 3 weeks and/or required intervention, and (c) was clinically meaningful to patients. Of these increases, 30.3% happened suddenly, 42.4% gradually, and for 27.3% criteria were inconclusive. Quantitative and qualitative criteria showed a very high agreement (Cohen’s κ = 0.85) regarding if a participant experienced a recurrence of depression, but a moderate agreement (Cohen’s κ = 0.49) regarding how that change occurred. At the micro-level, 41.1% of participants experienced only sudden increases in depressed mood, 12.5% only gradual, 30.4% experienced both types of increase, and 16.1% neither.

Conclusion
Meaningful change is common in patients discontinuing antidepressants, and there is substantial heterogeneity in how and when these changes occur. Depressive symptom change at the macro-level is not the same as depressive symptom change at the micro-level.
Hypothetical versus experienced health state valuation: a qualitative study of adult general public views and preferences
Authors: Powell Philip A. , Karimi Milad , Rowen Donna , Devlin Nancy , van Hout Ben , Brazier John E. 
Published: November 2022

Abstract
Objectives
Responses from hypothetical and experienced valuation tasks of health-related quality of life differ, yet there is limited understanding of why these differences exist, what members of the public think about them, and acceptable resolutions. This study explores public understanding of, opinions on, and potential solutions to differences between hypothetical versus experienced responses, in the context of allocating health resources.

Methods
Six focus groups with 30 members of the UK adult public were conducted, transcribed verbatim, and analysed using framework analysis. Participants self-completed the EQ-5D-5L, before reporting the expected consequences of being in two hypothetical EQ-5D-5L health states for ten years. Second, participants were presented with prior results on the same task from a public (hypothetical) and patient (experienced) sample. Third, a semi-structured discussion explored participants’: (1) understanding, (2) opinions, and (3) potential resolutions.

Results
Twenty themes emerged, clustered by the three discussion points. Most participants found imagining the health states difficult without experience, with those aligned to mental health harder to understand. Participants were surprised that health resource allocation was based on hypothetical responses. They viewed experienced responses as more accurate, but noted potential biases. Participants were in favour of better informing, but not influencing the public. Other solutions included incorporating other perspectives (e.g., carers) or combining/weighting responses.

Conclusion
Members of the UK public appear intuitively not to support using potentially uninformed public values to hypothetical health states in the context of health resource allocation. Acceptable solutions involve recruiting people with greater experience, including other/combinations of views, or better informing respondents.
Continuity correction: on the pricing of discrete double barrier options
Authors: Luo Sheng-Feng , Wong Hsin-Chieh 
Published: November 2022

AbstractThis article deals with the pricing of double-barrier options monitored discretely. A continuity correction method is established to provide an analytical approximation for the price of such discrete options under the Black–Scholes model. We achieve this by applying the smooth-fit principle simultaneously to the two flat boundaries (barriers) associated. The resulting correction form still involves adjustments in the levels of barriers, but the amounts adjusted can be different for different boundaries. More interestingly, the shift for each boundary can also be in different directions, which depends largely on the position of the current level relative to the two boundaries. Numerical examples are provided as well which support our theoretical achievements.
‘Getting the Right Nutrients to Those Who Need Them Most’: towards nutrition-sensitive governance of fisheries in the Global South
Authors: Allegretti Antonio , Hicks Christina C. 
Published: November 2022

AbstractHere we propose a framework and agenda for nutrition-sensitive governance (NSG) of fisheries that rethink dominant paradigms of fisheries governance and propose measures to incorporate nutrition-related objectives into fisheries governance. Fish, rich in micronutrients, have potential for improving the nutritional status of coastal and riparian communities, particularly in the Global South where inadequate nutrition is prevalent. Yet, the potential for fish to alleviate malnutrition remains limited to policy documents and high-level government commitments. We propose an agenda for NSG in the Global South grounded in three main pillars: 1-extending the boundaries of fisheries governance, 2-integrating multiple forms of knowledge, and 3-prioritizing domestic and local needs; each of these pillars links different levels of governance starting at the level of conceptualization and images connected to what fisheries are and should do, to a more policy-oriented level with hands-on recommendations, through an intermediate level that links the two. Overall, we propose a concept and agenda for NSG grounded in a human-centred approach to fisheries governance with social sciences playing a crucial role in unearthing the nodes of power that limit access and agency of poor and vulnerable (fishing) communities to the nutritional benefits of fish. In doing so, we critically analyze dominant fisheries governance agendas (‘Blue Economy’, ‘Blue Growth’) through the lens of food and nutrition security and anchor these debates to the objective of getting the right nutrients to those who need them most.
Animal Pose Tracking: 3D Multimodal Dataset and Token-based Pose Optimization
Authors: Patel Mahir , Gu Yiwen , Carstensen Lucas C. , Hasselmo Michael E. , Betke Margrit 
Published: November 2022

AbstractAccurate tracking of the 3D pose of animals from video recordings is critical for many behavioral studies, yet there is a dearth of publicly available datasets that the computer vision community could use for model development. We here introduce the Rodent3D dataset that records animals exploring their environment and/or interacting with each other with multiple cameras and modalities (RGB, depth, thermal infrared). Rodent3D consists of 200 min of multimodal video recordings from up to three thermal and three RGB-D synchronized cameras (approximately 4 million frames). For the task of optimizing estimates of pose sequences provided by existing pose estimation methods, we provide a baseline model called OptiPose. While deep-learned attention mechanisms have been used for pose estimation in the past, with OptiPose, we propose a different way by representing 3D poses as tokens for which deep-learned context models pay attention to both spatial and temporal keypoint patterns. Our experiments show how OptiPose is highly robust to noise and occlusion and can be used to optimize pose sequences provided by state-of-the-art models for animal pose estimation.
Applicability and Extraction Characteristics of Aluminum Sulfate as Extractant of Harmful Heavy Metals for On-Site Treatment of Deep-Sea Mining Tailings
Authors: Lee Gaeun , Kim Kyoungrean 
Published: November 2022

AbstractThis research was focused on the eco-friendly treatment of deep-sea mining tailings in the sea areas and mainly dealt with evaluating the optimal conditions by comparing aluminum sulfate (AS), which had been proven recently to have an effect as a heavy metal extractant, with ethylenediaminetetraacetic acid (EDTA) in terms of environmental and economic feasibility. Harmful heavy metals in the manganese nodules (2%, w/v) were chemically washed by mixing with each EDTA and AS concentration for 16 elapsed times. Copper, zinc, nickel, and cadmium, which could have a fatal effect due to their high total content or high bioavailable content, were selected as the primary treatment target materials. The content of harmful heavy metals was 293.2 times more for nickel when compared with environmental standards of various countries. When 1% AS was used as the extractant, the removal efficiency of harmful heavy metals compared to the bioavailable content was 32.77% on average. It has been verified that multi-stage treatment could be necessary, and the short treatment time could be an important factor. Within a short elapsed time (3 h), the remediation efficiency of zinc and nickel under the 1% AS condition was higher than with 0.1 M EDTA. In terms of environmental and economic feasibility, it was verified that the use of 1% AS would be reasonable. The results of this research could be valuably applied to process design and optimization as basic data presented before the development of remediation technologies in the future.
Graphical Abstract