bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERAN KEPALA MADRASAH SEBAGAI LEADER DI MTS MUHAMMADIYAH 1 PALEMBANG
Authors: Setyaningsih Kris , Astuti Serli Widia , Kanada Rabial , Ibrahim Ibrahim 
Published: December 2022

Abstract: This article is entitled the role of the madrasa head as a leader at Mts Muhammadiyah 1 Palembang. The source of data used by researchers in this study was obtained from MTs Muhammadiyah 1 Palembang. This article focuses on the role of the madrasah principal as a leader in mobilizing, directing, guiding, setting an example, and providing encouragement to teachers & staff, as well as students at MTs Muhammadiyah 1 Palembang. This study uses a descriptive qualitative research method by using data collection methods in this study are observation, interviews and documentation. The data obtained is then analyzed and presented again or data is reduced and then presented and then drawn conclusions. The results of this study indicate that the madrasah principal at MTs Muhammadiyah 1 Palembang carries out its role as a leader, by providing results in the form of achieving the vision and mission, activities that are ready to help teacher performance and encouragement of motivation for all madrasah residents by increasing the achievement and existence of educational institutions, adding facilities and infrastructure. madrasas and be a role model for all madrasa residents by applying discipline in time and in dress and behavior. The head of the madrasa is very influential in his role as a leader at MTs Muhammadiyah 1 Palembang because the leader is a leadership that influences members with various roles that must be applied in everyday life.Keywords: madrasah principal, leaderAbstrak: Artikel ini berjudul peran kepala madrasah sebagai leader di Mts Muhammadiyah 1 Palembang. Sumber data yang digunakan peneliti pada penelitian ini diperoleh dari MTs Muhammadiyah 1 Palembang. Adapun artikel ini berfokus pada peran kepala madrasah sebagai leader dalam menggerakan, mengarahkan, membimbing, memberi teladan, serta memberi dorongan kepada guru & staff, serta siswa di MTs Muhammadiyah 1 Palembang. Penelitian ini menggunakan metode peneltian yaitu deskriptif kualitatif dengan menggunakan metode pengumpulan data pada penelitian ini adalah observasi, wawancara dan dokumentasi. Data yang diperoleh kemudian dianalisis dan disajikan kembali atau direduksi data lalu disajikan kemudian ditarik kesimpulan. Hasil penelitian ini menunjukkan bahwasanya kepala madrasah di MTs Muhammadiyah 1 Palembang melaksanakan perannya sebagai leader, dengan memberikan hasil berupa pencapaian visi misi, kegiatan yang siap membantu kinerja guru serta dorongan motivasi untuk seluruh warga madrasah dengan peningkatan prestasi dan eksistensi lembaga pendidikan, penambahan sarana dan prasarana madrasah serta menjadi teladan bagi seluruh warga madrasah dengan menerapkan disiplin waktu dan dalam berpakaian maupun bersikap. Kepala madrasah sangatlah berpengaruh dalam perannya sebagai leader di MTs Muhammadiyah 1 Palembang karena leader merupakan kepemimpinan yang sifatnya mempengaruhi anggota dengan berbagai macam peran yang harus diaplikasikan dalam kehidupan sehari-hari.Kata Kunci: Kepala Madrasah, leader
LINK AND MATCH TABEL PUNET KANCING GENETIKA UNTUK MENINGKATKAN PRESTASI BELAJAR PEWARISAN SIFAT SISWA KELAS IX.B SMP NEGERI 1 GUNUNGSARI TAHUN 2021
Authors: Ukir Lalu 
Published: December 2022

Abstract: This research was conducted at SMP Negeri 1 Gunungsari, with the purposeto finding out the Link And Match of TablePunetkancinggenetika can make it easier for students to understand and improve their learned outcomes in the inheritance of living things. This type of research is classroom action research (CAR), which is carried out in two cycles, and each cycle is carried out in several stages that’s is, planning, implementing, observing and reflecting. Data from this researchis study from student’s learning activities and student learning outcomes. Data results from this research showed that using a punet table linked with genetic buttons, effectively improved the science learning outcomes of class IX.B Students on the subject of the law of inheritance of traits. this can be seen from the learning outcomes students from cycle I and cycle II with an average value of 67, 06 in the first cycle and the average value of 75.63 in the second cycle or an increase of 8.57. And the learning completeness from the first cycle was 45.16% and increased to 87.10% in the second cycle. And the increase in student achievement through the N-Gain test is 0.62 with moderate criteria. It can be concluded that learning activities using Link and Match between Punet Tables with Genetic Buttons can improve student learning outcomes in class IX.B SMP Negeri 1 Gunungsari.Key Words: Link and Match, Tabel Punet, Kancing Genetika.Abstrak: Penelitian ini dilaksanan di SMP Negeri 1 Gunungsari, Dengan tujuan Link And Match Tabel Punet Kancing Genetika dapat memudahkan siswa dalam memahami dan meningkatkan hasil belajarnya pada materihukumpewarisanmakhlukhidup.Jenis penelitian ini adalah penelitian tindakan kelas (PTK), yang dilakukan sebanyak dua siklus, dan setiap siklus dilakukan dengan beberapa tahapan yaitu : perencanaan, pelaksanaan, pengamatan dan refleksi. Data hasil pada penelitian ini adalah kegiatan belajar siswa dan hasil belajar siswa. Hasil penelitian menunjukkan bahwa dengan menggunkan table punet yang dilinkkan dengan kancing genetika, efektif meningkatkan hasil belajar mata pelajaran IPA siswa kelas IX.B pada materi Hukum pewarisan sifat. Hal ini dapat dilihat dari hasil belajar siswa dari siklus I dan siklus II dengan nilai rata-rata 67,06 pada siklus I dan nilai rata-rata sebesar 75,63 pada siklus II atau naik sebesar 8,57. Dan ketuntasan belajar dari siklus I sebesar 45,16 % naik menjadi 87,10 % pada siklus II. Dan peningkatan prestasi belajar siswa melalui uji N-Gain yaitu sebesar 0,62 dengan kriteria sedang. Sehingga dapat disimpulkan bahwa kegiatan belajar dengan menggunakan Link and Match antara Tabel Punet dengan Kancing Genetika dapat meningkatkan hasil belajar siswa kelas IX.B SMP Negeri 1 Gunungsari.Kata Kunci: Link and Match, Tabel Punet, Kancing Genetika.
Case report: Metastatic melanoma masquerading as apical hypertrophic cardiomyopathy
Authors: Ashraf Muddasir , Jahangir Arshad , Jan M. Fuad , Muthukumar Lakshmi , Neitzel Gary , Tajik A. Jamil 
Published: December 2022

BackgroundCardiac tumors are usually metastatic. Melanoma is the tumor with the highest rate of cardiac metastasis. Clinicians need to be aware of the metastatic involvement of the left ventricular apex as a differential diagnosis of apical hypertrophic cardiomyopathy.Case summaryA 74-year-old woman presented for evaluation of fatigue. The initial electrocardiogram and echocardiogram showed features of apical hypertrophic cardiomyopathy. The patient reported a lesion on her right forearm that had been present for many years, leading to its biopsy, which showed melanoma. Further evaluation with a chest-computed tomography (CT) scan showed left lung nodules and nodular thickening of the left ventricular apex. Positron emission tomography showed an increased uptake of fluorodeoxyglucose in the left lung nodule and left ventricular apex, suggestive of metastatic spread of the melanoma. A CT-guided biopsy of the left lung nodule revealed melanoma. The patient was treated with ipilimumab initially, followed by paclitaxel with poor response to treatment, and later passed under hospice care.ConclusionMetastatic tumors involving the left ventricular apex should be considered in the differential diagnosis of apical hypertrophic cardiomyopathy, especially in patients with a history of melanoma, and advanced cardiac imaging, including cardiac magnetic resonance imaging, CT, and/or positron emission tomography (PET) may help with narrowing down the differential diagnosis.
Circulating levels of DLK1 and glucose homeostasis in girls with obesity: A pilot study
Authors: Palumbo Stefania , Umano Giuseppina Rosaria , Aiello Francesca , Cirillo Grazia , Miraglia del Giudice Emanuele , Grandone Anna 
Published: December 2022

IntroductionDLK1 gene is considered a molecular gatekeeper of adipogenesis. DLK1 mutations have been reported as a cause of central precocious puberty associated with obesity and metabolic syndrome with undetectable DLK1 serum levels. We investigated the association between DLK1 circulating levels with clinical and biochemical parameters in obese adolescents and healthy controls.MethodsSixty-five obese adolescents and 40 controls were enrolled and underwent a complete clinical examination and biochemical assessment for glucose homeostasis and DLK1 plasma levels.ResultsWe observed lower DLK1 levels in cases compared to controls. Moreover, we found a negative correlation between DLK1 and HOMA-IR and a direct correlation with insulin-sensitivity index.DiscussionOur findings suggest that DLK1 might be involved in metabolic derangement in obese children.
Prenatal exposure to phenols and benzophenones in relation to markers of male reproductive function in adulthood
Authors: Holmboe Stine A. , Scheutz Henriksen Louise , Frederiksen Hanne , Andersson Anna-Maria , Priskorn Lærke , Jørgensen Niels , Juul Anders , Toppari Jorma , Skakkebæk Niels E. , Main Katharina M. 
Published: December 2022

IntroductionEnvironmental exposure during fetal life may disrupt testicular development. In humans, a limited number of studies have investigated whether these adverse effects persist into adulthood. Using data from a prospective, population-based birth cohort study, The Copenhagen Mother-Child cohort, the objective was to assess if there is an association between fetal exposure to selected phenols and benzophenones and markers of testicular function in adult men.MethodsPregnant women were recruited in 1997–2001. Their sons were examined clinically at 18-20 years of age, with focus on adult markers of reproductive function (anogenital distance (AGD), semen quality and reproductive hormones). In total, 101 18–20-year-old men were included, whose mothers during pregnancy had a serum sample drawn and analyzed for bisphenol A (BPA) and seven other simple phenols, as well as six benzophenones. To investigate the association between chemical levels (in tertiles, T1-T3) in relation to markers of reproductive function, univariate and multiple linear regression analyses were performed.ResultsIn fully adjusted analyses, increased levels of luteinizing hormone (LH) were observed with higher fetal exposure to BPA (percentage difference (95%CI)) (T2: 12% (-8%,36%) and T3: 33% (10%,62%), compared to T1) and benzophenone-3 (BP-3) (T2: 21% (-2%,49%), T3: 18% (-4%,45%)), while no clear association was seen to total testosterone (TT). Higher levels of BPA and BP-3 were associated with a lower TT/LH ratio, although only significant for BPA (p-trend=0.01). No associations were seen to AGD or markers of semen quality. ConclusionIn conclusion, high exposure to BPA and BP-3 was associated with a compensated reduced Leydig cell function but no other changes in markers of reproductive health. As maternal levels of BPA and BP-3 were not correlated, separate effects may be at play. Larger studies on long-term reproductive consequences of prenatal exposures are warranted to validate our findings.
Soil carbon dynamics in the temperate Himalayas: Impact of land use management
Authors: Kumar Shamal Shasang , Wani Owais Ali , Mir Shakeel Ahmad , Babu Subhash , Sharma Vikas , Chesti Majeed Ul Hassan , Baba Zahoor Ahmad , Sofi Parvaze Ahmad , Wani Fehim Jeelani , Dar Shahnawaz Rasool , Singh Raghavendra , Yadav Devideen 
Published: December 2022

Food security and environmental health are directly linked with soil carbon (C). Soil C plays a crucial role in securing food and livelihood security for the Himalayan population besides maintaining the ecological balance in the Indian Himalayas. However, soil C is being severely depleted due to anthropogenic activities. It is well known that land use management strongly impacted the soil organic carbon (SOC) dynamics and also regulates the atmospheric C chemistry. Different types of cultivation practices, i.e., forest, plantations, and crops in the Kashmir Himalayas, India, has different abilities to conserve SOC and emit C in the form of carbon dioxide (CO2). Hence, five prominent land use systems (LUC) (e.g., natural forest, natural grassland, maize-field-converted from the forest, plantation, and paddy crop) of Kashmir Himalaya were evaluated to conserve SOC, reduce C emissions, improve soil properties and develop understanding SOC pools and its fractions variations under different land use management practices. The results revealed that at 0–20 cm and 20–40 cm profile, the soil under natural forest conserved the highest total organic carbon (TOC, 24.24 g kg−1 and 18.76 g kg−1), Walkley-black carbon (WBC, 18.23 g kg−1 and 14.10 g kg−1), very-labile-carbon (VLC, 8.65 g kg−1, and 6.30 g kg−1), labile-carbon (LC, 3.58 g kg−1 and 3.14 g kg−1), less-labile-carbon (VLC, 2.59 g kg−1, and 2.00 g kg−1), non-labile-carbon (NLC, 3.41 g kg−1 and 2.66 g kg-1), TOC stock (45.88 Mg ha−1 and 41.16 Mg ha−1), WBC stock (34.50 Mg ha−1 and 30.94 Mg ha−1), active carbon pools (AC, 23.14 Mg ha−1 and 20.66 Mg ha−1), passive carbon pools (PC, 11.40 Mg ha−1 and 10.26 Mg ha−1) and carbon management index (CMI, 100), followed by the natural grassland. However, the lowest C storage was reported in paddy cropland. The soils under natural forest and natural grassland systems had a greater amount of VLC, LC, LLC, and NLC fraction than other land uses at both depths. On the other hand, maize-field-converted-from-forest-land-use soils had a higher proportion of NLC fraction than paddy soils; nonetheless, the NLC pool was maximum in natural forest soil. LUS based on forest crops maintains more SOC, while agricultural crops, such as paddy and maize, tend to emit more C in the Himalayan region. Therefore, research findings suggest that SOC under the Kashmir Himalayas can be protected by adopting suitable LUS, namely forest soil protection, and by placing some areas under plantations. The areas under the rice and maize fields emit more CO2, hence, there is a need to adopt the conservation effective measure to conserve the SOC without compromising farm productivity.
Spatiotemporal variation characteristics of hourly soil temperature in different layers in the low-latitude plateau of China
Authors: Cheng Qingping , Zhang Mingda , Jin Hanyu , Ren Yitong 
Published: December 2022

Soil temperature change has considerable impact on land surface energy and water balances, and hence on changes in weather/climate, surface/subsurface hydrology, and ecosystems. However, little is known regarding the spatiotemporal variations and influencing factors of changes in hourly soil temperature (depth: 5–320 cm) in low-latitude highland areas. This study analyzed the hourly soil temperature at each hour during 2004–2020 and at 08:00, 14:00, and 20:00 (Beijing Time) during 1961–2020. The results revealed the following. 1) As soil depth increased, average soil temperature increased in autumn and winter, and decreased annually and in spring and summer. It exhibited significant increase during 00:00–23:00 annually, seasonally, and monthly, especially at depths of 40–320 cm during 2004–2020. Average soil temperature increased at 08:00 and decreased at 14:00 and 20:00 with increasing soil depth, but the opposite trend was found annually, seasonally, and monthly at 08:00, 14:00, and 20:00 during 1961–2020. 2) With increasing elevation, average soil temperature decreased at 08:00, 14:00, and 20:00 at depths of 5–20 cm, and showed significant increase trend at 08:00 and 14:00 at depths of 10–20 cm (except at 14:00 at 10-cm depth). 3) At 5-cm depth, the critical accumulated soil temperature of ≥12°C and 14°C extended the potential growing season during 1961–2020. 5) Significant uptrend of hourly soil temperature annually, seasonally, and monthly potentially leads to additional release of carbon to the atmosphere and increased soil respiration, reinforcing climate warming. These findings contribute to better understanding of the variation of shallow soil temperatures and land–atmosphere interactions in low-latitude highland areas.
Bidirectional associations between eosinophils, basophils, and lymphocytes with atopic dermatitis: A multivariable Mendelian randomization study
Authors: Zeng-Yun-Ou Zhang , Zhong-Yu Jian , Wei Li 
Published: December 2022

BackgroundDespite being prone to reverse causation and having unmeasured confounding factors, many clinical observational studies have highlighted the critical association between basophils, eosinophils, and lymphocytes and atopic dermatitis (AD). Whether these cells play a causal role in AD development remains uncertain.MethodsData were obtained from the UK Biobank and the Blood Cell Consortium, from a large publicly available genome-wide association study (GWAS) with more than 500,000 subjects of European ancestry and for AD from three independent cohorts with more than 700,000 subjects of European ancestry. We performed single-variable Mendelian randomization (SVMR), followed by multivariable Mendelian randomization (MVMR) to assess the total and direct effects of immune cell counts on AD risk.ResultsSVMR estimates showed that genetically predicted higher eosinophil [odds ratio (OR): 1.23, 95% confidence interval (CI): 1.17–1.29, p = 5.85E−16] and basophil counts (OR: 1.11, 95% CI: 1.03–1.19, p = 0.004) had an adverse effect on the risk of AD, while a higher lymphocyte count (OR: 0.93, 95% CI: 0.89–0.98, p = 0.006) decreased the risk. Reverse MR analysis showed higher basophil (beta: 0.04, 95% CI: 0.01–0.07, p = 0.014) and lower lymphocyte counts (beta: −0.05, 95% CI: −0.09 to −0.01, p = 0.021) in patients with AD. In MVMR, the effects of eosinophils (OR: 1.19, 95% CI: 1.09–1.29, p = 8.98E−05), basophils (OR: 1.19, 95% CI: 1.14–1.24, p = 3.72E−15), and lymphocytes (OR: 0.93, 95% CI: 0.89–0.98, p = 0.006) were still significant.DiscussionMendelian randomization (MR) findings suggest that an increase in the eosinophil and basophil counts and a decrease in the lymphocyte counts are potential causal risk factors for AD. These risk factors are independent of each other.
Occurrence of mcr-1 and mcr-2 colistin resistance genes in porcine Escherichia coli isolates (2010–2020) and genomic characterization of mcr-2-positive E. coli
Authors: Ewers Christa , Göpel Lisa , Prenger-Berninghoff Ellen , Semmler Torsten , Kerner Katharina , Bauerfeind Rolf 
Published: December 2022

IntroductionThe global emergence of plasmid-mediated colistin resistance is threatening the efficacy of colistin as one of the last treatment options against multi-drug resistant Gram-negative bacteria. To date, ten mcr-genes (mcr-1 to mcr-10) were reported. While mcr-1 has disseminated globally, the occurrence of mcr-2 was reported scarcely.Methods and resultsWe determined the occurrence of mcr-1 and mcr-2 genes among Escherichia coli isolates from swine and performed detailed genomic characterization of mcr-2-positive strains. In the years 2010-2017, 7,614 porcine E. coli isolates were obtained from fecal swine samples in Europe and isolates carrying at least one of the virulence associated genes predicting Shiga toxin producing E. coli (STEC), enterotoxigenic E. coli (ETEC) or enteropathogenic E. coli (EPEC) were stored. 793 (10.4%) of these isolates carried the mcr-1 gene. Of 1,477 additional E. coli isolates obtained from sheep blood agar containing 4 mg/L colistin between 2018 and 2020, 36 (2.4%) isolates were mcr-1-positive. In contrast to mcr-1, the mcr-2 gene occurred at a very low frequency (0.13%) among the overall 9,091 isolates. Most mcr-2-positive isolates originated from Belgium (n = 9), one from Spain and two from Germany. They were obtained from six different farms and revealed multilocus sequence types ST10, ST29, ST93, ST100, ST3057 and ST5786. While the originally described mcr-2.1 was predominant, we also detected a new mcr-2 variant in two isolates from Belgium, which was termed mcr-2.8. MCR-2 isolates were mostly classified as ETEC or ETEC-like, while one isolate from Spain represented an atypical enteropathogenic E. coli (aEPEC; eae+). The ST29-aEPEC isolate carried mcr-2 on the chromosome. Another eight isolates carried their mcr-2 gene on IncX4 plasmids that resembled the pKP37-BE MCR-2 plasmid originally described in Belgium in 2015. Three ST100 E. coli isolates from a single farm in Belgium carried the mcr-2.1 gene on a 47-kb self-transmissible IncP type plasmid of a new IncP-1 clade.DiscussionThis is the first report of mcr-2 genes in E. coli isolates from Germany. The detection of a new mcr-2 allele and a novel plasmid backbone suggests the presence of so far undetected mcr-2 variants and mobilizable vehicles.
Differential impact of body mass index and leptin on baseline and longitudinal positron emission tomography measurements of the cerebral metabolic rate for glucose in amnestic mild cognitive impairment
Authors: Weise Christopher M. , Chen Kewei , Chen Yinghua , Devadas Vivek , Su Yi , Reiman Eric M. 
Published: December 2022

IntroductionSeveral studies have suggested that greater adiposity in older adults is associated with a lower risk of Alzheimer’s disease (AD) related cognitive decline, some investigators have postulated that this association may be due to the protective effects of the adipose tissue-derived hormone leptin. In this study we sought to demonstrate that higher body mass indices (BMIs) are associated with greater baseline FDG PET measurements of the regional cerebral metabolic rate for glucose (rCMRgl), a marker of local neuronal activity, slower rCMRgl declines in research participants with amnestic mild cognitive impairment (aMCI). We then sought to clarify the extent to which those relationships are attributable to cerebrospinal fluid (CSF) or plasma leptin concentrations.Materials and methodsWe used baseline PET images from 716 73 ± 8 years-old aMCI participants from the AD Neuroimaging Initiative (ADNI) of whom 453 had follow up images (≥6 months; mean follow up time 3.3 years). For the leptin analyses, we used baseline CSF samples from 81 of the participants and plasma samples from 212 of the participants.ResultsAs predicted, higher baseline BMI was associated with greater baseline CMRgl measurements and slower declines within brain regions preferentially affected by AD. In contrast and independently of BMI, CSF, and plasma leptin concentrations were mainly related to less baseline CMRgl within mesocorticolimbic brain regions implicated in energy homeostasis.DiscussionWhile higher BMIs are associated with greater baseline CMRgl and slower declines in persons with aMCI, these associations appear not to be primarily attributable to leptin concentrations.