bluuebunny/crossref_metadata_2025_split huggingface dataset:
Locking Active Li Metal through Localized Redistribution of Fluoride Enabling Stable Li‐Metal Batteries
Authors: Li Guocheng , Duan Xiangrui , Liu Xueting , Zhan Renming , Wang Xiancheng , Du Junmou , Chen Zihe , Li Yuanjian , Cai Zhao , Shen Yue , Sun Yongming 
Published: October 2022

AbstractThe creation of fluorinated interphase has emerged as an effective strategy for improving Li‐metal anodes for rechargeable high‐energy batteries. In contrast to the introduction of fluorine‐containing species through widely adopted electrolyte engineering, a Li‐metal composite design is reported in which LiF can locally redistribute on the Li‐metal surface in liquid electrolytes via a dissolution–reprecipitation mechanism, and enable the formation of a high‐fluorine‐content solid electrolyte interphase (SEI). For validation, a Li/Li22Sn5/LiF ternary composite is investigated, where the as‐formed LiF‐rich SEI locks the active Li metal from corrosive electrolyte. The Li/Li22Sn5/LiF anode displays an impressive average Coulombic efficiency (ACE, ≈99.2%) at 1 mA cm−2 and 1 mAh cm−2 in a carbonate electrolyte and a remarkable cycling life of over 1600 h at 1 mA cm−2 and 2 mAh cm−2. Applied to a LiCoO2 full cell with a high cathode areal capacity of 4.0 mAh cm−2, a high capacity retention of ≈91.1% is realized for 100 cycles at 0.5 C between 2.8 to 4.5 V with a low negative/positive (N/P) ratio of 2:1. This design is conceptually different from the design employing the widely used fluorine‐containing electrolyte additive and provides an alternative approach to realize reliable Li‐metal batteries.
Systematic Substituent Control in Blue Thermally Activated Delayed Fluorescence (TADF) Emitters: Unraveling the Role of Direct Intersystem Crossing between the Same Charge‐Transfer States
Authors: Ryoo Chi Hyun , Han Jongseok , Yang Jung‐hoon , Yang Kwangmo , Cho Illhun , Jung Seyoung , Kim Sehun , Jeong Hyein , Lee Changhee , Kwon Ji Eon , Serdiuk Illia E. , Park Soo Young 
Published: October 2022

AbstractA molecular structural approach is applied by introducing substituent groups (X) to explore the structure–property correlation of thermally activated delayed fluorescence (TADF) mechanism and develop blue TADF materials. D–A–X emitters show blue emissions from 446 to 487 nm and exhibit high rate constants of reverse intersystem crossing (krISC) from 0.76 × 106 to 2.13 × 106 s−1. Organic light emitting diodes (OLEDs) based on D–A–X emitters exhibit efficient external quantum efficiency from 17.2% to 23.9%. Furthermore, the theoretical analysis of spin–flip transitions between states of various nature reveals that the highest rISC rates can be achieved by the increase of charge‐transfer (CT) strength and enhancement of direct transition between triplet (3CT) and singlet (1CT) charge transfer states. Rotational tolerance of dihedral angle, low energy gap, and low reorganization energy between the 3CT and 1CT states provides fast rISC even when triplet states of different (LE) nature have much higher energy not to enable the three‐level interaction. By both experimental and theoretical methods, the investigations reveal that for the design of efficient TADF‐OLED emitters, the enhancement of the 3CT–1CT transition is as much important as that of 3LE–1CT.
Structural‐Functional Pluralistic Modification of Silk Fibroin via MOF Bridging for Advanced Wound Care
Authors: Zhu Zhou , Liu Yanhua , Chen Junyu , He Zihan , Tan Pengfei , He Yong , Pei Xibo , Wang Jian , Tan Lin , Wan Qianbing 
Published: October 2022

AbstractSilk fibroin (SF) is widely used to fabricate biomaterials for skin related wound caring or monitoring, and its hydrogel state are preferred for their adaptability and easy to use. However, in–depth development of SF hydrogel is restricted by their limited mechanical strength, increased risk of infection, and inability to accelerate tissue healing. Therefore, a structure–function pluralistic modification strategy using composite system of metal organic framework (MOF) as bridge expanding SF's biomedical application is proposed. After developing the photocuring and bonding SF hydrogel, a MOF drug–loading system is utilized to enhance hydrogel's structural strength while endowing its antibacterial and angiogenic properties, yielding a multifunctional SF hydrogel. The synergy between the MOF and SF proteins at the secondary structure level gives this hydrogel reliable mechanical strength, making it suitable for conventional wound treatment, whether for closing incisions quickly or acting as adhesive dressings (five times the bonding strength of ordinary fibrin glue). Additionally, with the antibacterial and angiogenic functions getting from MOF system, this modified SF hydrogel can even treat ischemic trauma with cartilage exposure. This multiple modification should contribute to the improvement of advanced wound care, by promoting SF application in the production of tissue engineering materials.
Upregulation of Superenhancer‐Driven LncRNA FASRL by USF1 Promotes De Novo Fatty Acid Biosynthesis to Exacerbate Hepatocellular Carcinoma
Authors: Peng Jiang‐Yun , Cai Dian‐Kui , Zeng Ren‐Li , Zhang Chao‐Yang , Li Guan‐Cheng , Chen Si‐Fan , Yuan Xiao‐Qing , Peng Li 
Published: October 2022

AbstractSuperenhancers drive abnormal gene expression in tumors and promote malignancy. However, the relationship between superenhancer‐associated long noncoding RNA (lncRNA) and abnormal metabolism is unknown. This study identifies a novel lncRNA, fatty acid synthesis‐related lncRNA (FASRL), whose expression is driven by upstream stimulatory factor 1 (USF1) through its superenhancer. FASRL promotes hepatocellular carcinoma (HCC) cell proliferation in vitro and in vivo. Furthermore, FASRL binds to acetyl‐CoA carboxylase 1 (ACACA), a fatty acid synthesis rate‐limiting enzyme, increasing fatty acid synthesis via the fatty acid metabolism pathway. Moreover, the expression of FASRL, USF1, and ACACA is increased, and their high expression indicates a worse prognosis in HCC patients. In summary, USF1 drives FASRL transcription via a superenhancer. FASRL binding to ACACA increases fatty acid synthesis and lipid accumulation to mechanistically exacerbate HCC. FASRL may serve as a novel prognostic marker and treatment target in HCC.
Photocatalytic Pt(IV)‐Coordinated Carbon Dots for Precision Tumor Therapy
Authors: Guo Dongbo , Lei Josh Haipeng , Rong Dade , Zhang Tesen , Zhang Bohan , Tang Zikang , Shen Han‐Ming , Deng Chu‐Xia , Qu Songnan 
Published: October 2022

AbstractRapid, efficient, and precise cancer therapy is highly desired. Here, this work reports solvothermally synthesized photoactivatable Pt(IV)‐coordinated carbon dots (Pt‐CDs) and their bovine serum albumin (BSA) complex (Pt‐CDs@BSA) as a novel orange light‐triggered anti‐tumor therapeutic agent. The homogeneously distributed Pt(IV) in the Pt‐CDs (Pt: 17.2 wt%) and their carbon cores with significant visible absorption exhibit excellent photocatalytic properties, which not only efficiently releases cytotoxic Pt(II) species but also promotes hydroxy radical generation from water under orange light. When triggered with a 589 nm laser, Pt‐CDs@BSA possesses the ultrastrong cancer cell killing capacities of intracellular Pt(II) species release, hydroxyl radical generation, and acidification, which induce powerful immunogenic cell death. Activation of Pt‐CDs@BSA by a single treatment with a 589 nm laser effectively eliminated the primary tumor and inhibited distant tumor growth and lung metastasis. This study thus presents a new concept for building photoactivatable Pt(IV)‐enriched nanodrug‐based CDs for precision cancer therapy.
Suppressing Chemical Corrosions of Lithium Metal Anodes
Authors: Lu Bingyu , Li Weikang , Cheng Diyi , Bhamwala Bhargav , Ceja Miguel , Bao Wurigumula , Fang Chengcheng , Meng Ying Shirley 
Published: October 2022

AbstractThe lithium metal anode is essential for next‐generation high‐energy‐density rechargeable Li‐metal batteries. Although extensive studies have been performed to prolong the cycle life of Li‐metal batteries, the calendar life, which associates with the chemical corrosion of Li metal in liquid electrolytes, has not been quantitatively understood. Here, by combing the titration gas chromatography method and cryogenic focused ion beam, a quantitative relationship between the chemical corrosion rate and electrochemically deposited Li morphology in various liquid electrolyte systems is established. It has been identified that the corrosion rate is dominated by the porosity of the deposited Li. The larger the porosity of deposited Li has, the faster the corrosion rate will be. Strategies to mitigate the chemical corrosion on Li thus to extend the calendar life of Li‐metal batteries are further proposed. By strictly controlling the stacking pressure during Li plating, Li deposits with ultra‐low porosity can be achieved, suppressing the corrosion rate to 0.08 ± 0.16%/day compared with 1.71 ± 0.19%/day of the high‐porosity Li.
Fluorogenic detection of mercury ion in aqueous environment using hydrogel‐based AIE sensing films
Authors: Wu Shujun , Yang Yujiao , Cheng Yao , Wang Shuodong , Zhou Zhibiao , Zhang Pei , Zhu Xinqi , Wang Baodui , Zhang Hua , Xie Sheng , Zeng Zebing , Tang Ben Zhong 
Published: October 2022

AbstractA “turn‐on” fluorescent sensing strategy was developed for ultrasensitive detection of heavy metal mercury ion (Hg2+) directly in water. It utilized an aqueous soluble aggregation‐induced emission (AIE)‐active probe, named 1,1,2,2‐tetrakis(4‐(1H‐tetrazol‐5‐yl)phenyl)ethene (TPE‐4TA), composing of a luminescent tetraphenylene core and multiple anionic tetrazolate spawns. The probe retained dark when molecularly dissolved in water. However, mercury ions can ligate with multiple tetrazolate groups to form infinite coordination polymer particles spontaneously, thus inducing a fluorogenic AIE response for in situ analysis. Moreover, by embedding this AIE sensing molecules in a hydrophilic polyvinyl alcohol substrate, the resulting hydrogel film allowed in situ detection of Hg2+ on a laser‐induced fluorescence analysis setup in aqueous environment. This strategy worked effectively in common aqueous environments with pH from 4 to 7.5 and showed high sensitivity (limit of detection down to 0.38 ppb/1.9 nM), good selectivity and a wide linearity range for quantification. This work may lead to a reliable and promising platform for on‐site environmental water analysis.
A large, ten‐generation family with autosomal dominant preaxial polydactyly/triphalangeal thumb: Historical, clinical, genealogical, and molecular studies
Authors: Álvarez Luis Francisco González , Tenorio‐Castaño Jair , Poletta Fernando A. , Santos‐Simarro Fernando , Arias Pedro , Gallego Natalia , Orioli Iêda Maria , Mundlos Stefan , Castilla Eduardo E. , Martínez‐Glez Víctor , Martínez‐Frías María Luisa , Ruiz‐Pérez Víctor L. , Nevado Julián , Lapunzina Pablo 
Published: October 2022

AbstractWe present a large, ten‐generation family of 273 individuals with 84 people having preaxial polydactyly/triphalangeal thumb due to a pathogenic variant in the zone of polarizing activity regulatory sequence (ZRS) within the exon 5 of LMBR1. The causative change maps to position 396 of the ZRS, located at position c.423 + 4909C > T (chr7:156791480; hg38; LMBR1 ENST00000353442.10; rs606231153 NG_009240.2) in the intron 5 of LMBR1. The first affected individual with the disorder was traced back to mid‐1700, when some settlers and workers established in Cervera de Buitrago, a small village about 82 km North to Madrid. Clinical and radiological studies of most of the affected members have been performed for 42 years (follow‐up of the family by LFGA). Molecular studies have confirmed a pathogenic variant in the ZRS that segregates in this family. To the best of our knowledge, this is the largest family with preaxial polydactyly/triphalangeal thumb reported so far.
Biallelic GTF2IRD1 variants in brothers with profound neurodevelopmental disorder: A possible novel disorder involving a critical gene for Williams syndrome
Authors: Cummings Christopher Thomas , Starr Lois Janelle 
Published: October 2022

AbstractGTF2IRD1, a gene on chromosome 7 which encodes a transcription factor, is of significant clinical interest due to its heterozygous loss as part of the classical deletion associated with Williams–Beuren syndrome (WBS). However, biallelic variants in GTF2IRD1 alone as part of an autosomal recessive disease have not been previously reported. Here, we present two full brothers with variants in trans of GTF2IRD1 at c.1231C > T (p.Arg411Trp) and c.2632C > G (p.Leu878Val). A detailed clinical phenotype is described, which includes severe neurodevelopmental disability, facial dysmorphology, and pectus excavatum. Importantly, out of eight full siblings, only these two brothers harboring both variants in trans present with the profound described phenotype. We present the possibility that these brothers represent the identification of a new syndrome characterized by biallelic variants in GTF2IRD1, which may also have important implications for the molecular etiology of WBS.
Engineering pedicled vascularized bladder tissue for functional bladder defect repair
Authors: Yu Mingming , Chen Jiasheng , Wang Lin , Huang Yichen , Xie Hua , Bian Yu , Chen Fang 
Published: October 2022

AbstractAn engineered bladder construct that mimics the structural and functional characteristics of native bladder is a promising therapeutic option for bladder substitution. We previously showed that pedicled vascularized smooth muscle tissue fabricated by grafting smooth muscle cell (SMC) sheets onto an axial capsule vascular bed had the potential for reliable bladder reconstruction. In this study, we investigated the feasibility of buccal mucosa graft (BMG) integration with the pedicled vascularized smooth muscle tissue to generate a full‐layer pedicled vascularized bladder construct. BMG transplanted onto vascularized smooth muscle tissue showed good survival and developed into a pedicled vascularized bladder construct with full‐layer structures, appropriate thickness, abundant vascularization, and effective barrier function. Then the full‐thickness bladder defects were, respectively, reconstructed by pedicled capsule tissue (pedicled capsule group), nonpedicled vascularized bladder construct (nonpedicled construct group), and pedicled vascularized bladder construct (pedicled construct group). The picrosirius red (PSR) staining and immunohistochemistry results showed minimal fibrosis, maximal smooth muscle proportion, and high vascular density in the pedicled construct group. A continuous mucosal layer was observed only in the pedicled construct group. Moreover, morphological and functional studies revealed better bladder compliance and good ductility in the pedicled construct group. Overall, these results suggested that the BMG could be well integrated with vascularized smooth muscle tissue and generated a pedicled, fully vascularized, and structurally organized bladder construct, which facilitated structural remodeling and functional recovery and could become an alternative to bladder reconstruction.
How talking therapists experience working with adult clients who have autism
Authors: Brook Yvette 
Published: October 2022

AbstractThis research aims to gain new insight by exploring the thoughts, feelings and experiences of therapists working with clients who have autism. Three professional talking therapists participated in the study. Unstructured interviews were conducted and analysed using interpretive phenomenological analysis. Six main themes and 13 sub‐themes were found which include therapists’ validation of autism, how therapists integrated autism when addressing mental health problems, how their personal experiences of autism impacted on their work and how they experienced the situation in which autism emerges during the therapy. Helpful suggestions are made for clinicians, namely, to zoom‐in and zoom‐out of autism, hold the knowledge that people with autism process information differently, incorporate working with trauma, consider disclosing a personal connection to autism and consider carefully whether, or not, to tell a client that they may have autism.
mRNA Manufacturing and Single‐use Technology – A Perfect Liaison
Authors: Grilo António L. , Schmidhalter Diego R. 
Published: October 2022

AbstractThe Covid‐19 pandemic imposed a lockdown on the world. In this situation, the pharmaceutical industry reacted with incredible speed and delivered vaccines at the global scale in record time. Critical to this major accomplishment were existing mRNA vaccine expertise and single‐use manufacturing technologies. The combination of a moderate facility footprint requirement for mRNA production and the flexibility of disposable technology allowed rapid scale‐up and scale‐out of vaccine manufacturing, even over multiple continents. The present paper discusses opportunities provided by single‐use process solutions for mRNA manufacturing using the Covid‐19 vaccines as a case study.
Patient‐reported outcomes with cemiplimab monotherapy for first‐line treatment of advanced non–small cell lung cancer with PD‐L1 of ≥50%: The EMPOWER‐Lung 1 study
Authors: Gümüş Mahmut , Chen Chieh‐I , Ivanescu Cristina , Kilickap Saadettin , Bondarenko Igor , Özgüroğlu Mustafa , Gogishvili Miranda , Turk Haci M. , Cicin Irfan , Harnett James , Mastey Vera , Naumann Ulrike , Reaney Matthew , Konidaris Gerasimos , Sasane Medha , Brady Keri J. S. , Li Siyu , Gullo Giuseppe , Rietschel Petra , Sezer Ahmet 
Published: October 2022

AbstractBackgroundIn the EMPOWER‐Lung 1 trial (ClinicalTrials.gov, NCT03088540), cemiplimab conferred longer survival than platinum‐doublet chemotherapy for advanced non–small cell lung cancer (NSCLC) with programmed cell death‐ligand 1 (PD‐L1) ≥50%. Patient‐reported outcomes were evaluated among trial participants.MethodsAdults with NSCLC and Eastern Cooperative Oncology Group performance status 0 to 1 were randomly assigned cemiplimab 350 mg every 3 weeks or platinum‐doublet chemotherapy. At baseline and day 1 of each treatment cycle, patients were administered the European Organization for Research and Treatment of Cancer Quality of Life‐Core 30 (QLQ‐C30) and Lung Cancer Module (QLQ‐LC13) questionnaires. Mixed‐model repeated measures analysis estimated overall change from baseline for PD‐L1 ≥50% and intention‐to‐treat populations. Kaplan–Meier analysis estimated time to definitive deterioration.ResultsIn PD‐L1 ≥50% patients (cemiplimab, n = 283; chemotherapy, n = 280), baseline QLQ‐C30 and QLQ‐LC13 scores showed moderate‐to‐high functioning and low symptom burden. Change from baseline favored cemiplimab on global health status/quality of life (GHS/QOL), functioning, and most symptom scales. Risk of definitive deterioration across functioning scales was reduced versus chemotherapy; hazard ratios were 0.48 (95% CI, 0.32‐0.71) to 0.63 (95% CI, 0.41‐0.96). Cemiplimab showed lower risk of definitive deterioration for disease‐related (dyspnea, cough, pain in chest, pain in other body parts, fatigue) and treatment‐related symptoms (peripheral neuropathy, alopecia, nausea/vomiting, appetite loss, constipation, diarrhea) (nominal p < .05). Results were similar in the intention‐to‐treat population.ConclusionsResults support cemiplimab for first‐line therapy of advanced NSCLC from the patient's perspective. Improved survival is accompanied by improvements versus platinum‐doublet chemotherapy in GHS/QOL and functioning and reduction in symptom burden.
A systematic literature review on sensitive data protection in blockchain applications
Authors: Khanum Saba , Mustafa Khurram 
Published: October 2022

SummarySince inception, blockchain has earned significant attention due to its exclusive characteristics and advantages. It has changed the way the transactions are conducted by eradicating the role of third parties and promises to ensure trust among the participants. This technology is emerging as a potential solution to several issues but not without certain security vulnerabilities. In particular, protection of sensitive data is a more critical issue in the absence of a third party. This paper is aimed to report and share the state of the art of sensitive data protection in blockchain applications. The covered aspects include identification of sensitive data, existing techniques to protect sensitive data and to know how real time data compromised by security risks, attacks, threats and vulnerabilities concerning blockchain applications. This paper analysis the tools and techniques used in the past for protecting sensitive data and categorized them. On the basis of research and intuitive findings, methods and techniques are elaborated which can contribute in future in the designing a framework for protection of sensitive data in blockchain applications.
Removal of noise on mammogram breast images using filtering methods
Authors: Mudrakola Swapna , Hegde Nagaratna 
Published: October 2022

SummaryDetecting Breast Cancer (BC) at an early stage can reduce the rate of mortality. A mammogram is a preliminary examination of breast cancer with an optimistic and accurate method, for the same test will be used to know the behavior of the tumor in all stages of cancer. Unpolished Images need to process for a clear image to analyze, and enhanced images can use to view the tissue, muscle, and tumor. Image processing methods are not only used to remove the noisy pixels but also help to extract the Region of Interest (RoI) from the image. The size and structure of the tumor will be extracted using statistical analysis. This study was experimented on mammogram images by analyzing the types of noise on the image and filtering methods applied for a specific class of noise data. The different filtering approaches like Adaptive, Gaussian, Threshold, Mean, Mean‐Median, Bilateral, Wiener, and Tri‐State Filters were used. Mammogram images are grayscale images. The objective of this research experiment is noise data will reduce the detection factors of the tumor with True−Ve and False+Ve results. Fault results will impact the accuracy to identify the RoI. Image Preprocessing will help to improve the quality of the images and help in the treatment plan and expert advice in the decision of the disease stage. Results: The Dataset used images from CBIS‐DDSM (The Curated Breast Imaging Subset of DDSM‐[Digital Database for Screening Mammography]). The obtained Peak‐signal‐to‐Noise Ratio (PSNR) achieved is 80% minimum.
The 4R QTLs pollen fertility restoration in triticale with CMS Triticum timopheevii
Authors: Niedziela Agnieszka , Wasiak Marzena , Wojciechowska Marzena , Orłowska Renata , Dynkowska Wioletta Monika , Bany Sławomir , Bednarek Piotr Tomasz 
Published: October 2022

AbstractThe Triticum timopheevii Zhuk. (Tt) cytoplasm is the most exploited cytoplasmic male sterility (CMS) type used in triticale in commercial seed production of hybrid varieties. The present study established a recombinant inbred line (RIL) mapping population to identify genetic loci controlling fertility restoration in triticale with CMS Tt. The trait was evaluated via phenotyping the BC1F1 materials originating from a backcross of maternal line MS 112(15)‐2‐1 (on CMS Tt) and RILs. A genetic map spanning 2293 cM over 21 linkage groups was constructed using 1,170 single nucleotide polymorphisms and silico diversity array technology (DArT) markers generated through DArTseq genotyping. Two quantitative trait loci (QTL) controlling fertility restoration were localized at the 4RL chromosome. They were stable during two vegetative seasons and, depending on the year, explained 17.8 to 37.5 (QRft‐4R.1) and 17.8 to 27.1% (QRft‐4R.2) of phenotypic variance. Bioinformatic analysis was performed to predict genes potentially responsible for the trait. Four markers linked to the trait were successfully converted into a polymerase chain reaction‐based assay to select the pollen fertility QTLs easily. The exact position of QTLs detected previously in the rye and here in the triticale suggests that the same loci might control the trait.