bluuebunny/crossref_metadata_2025_split huggingface dataset:
Specificity of clinical trials of some osteoporosis medicines
Authors: Ivanova Stefka , Petkova Valentina 
Published: January 2022

Clinical trials of medicinal products related to the prevention and treatment of osteoporosis cover all activities, operations, methods and means for obtaining summary data and their interpretation in order to reveal the nature of the procedures, as well as certain relationships and dependencies of interest imposed the relevant study. The main objectives of the analysis are to characterize the relationships and dependencies, to measure the significance of these relationships, to model statistically significant relationships and dependencies. An important condition for conducting the statistical analysis is that the data are comparable, i.e. to be based on unambiguously defined features and criteria for their internal content.
Objective: This work covers a documentary analysis of conducted clinical trials of drugs for the treatment of osteoporosis, as well as an analysis of the conducted clinical trials of the drug.
Denosumab.
Methods: Gathering primary empirical information, allowing for: objectification of certain facts; for retrospective study of events and phenomena in a long period; allows to determine the direction of development of the process of clinical trials and processes. The applied statistical analysis covers activities, operations, methods and means for obtaining summary data and for their interpretation in order to reveal the nature of the procedures, as well as certain connections and dependencies.
Results: Studies show that clinical trials of osteoporosis products have the following limitations: gender differentiation – although the disease occurs in both sexes, studies in female patients are more common, patients are required to are in menopause, in some studies it is required as including criteria – the presence of a fracture due to osteoporosis, the age characteristic of patients is on average 45–80 years. All analyzed drugs show a positive effect on the state of bone density and bone structure.
Conclusion: All analyzed medicinal products show a positive effect on the state of bone density and bone structure but the process is irreversible, so early prevention associated with early diagnosis would lead to earlier treatment measures in the early stages of the disease, which in turn, it would lead to long-term savings in indirect and difficult-to-estimate costs for society as a whole.
Pacientes con compromiso orbitario y renal. Diagnósticos diferenciales poco frecuentes
Authors: Correa Lemos María Eugenia , Sager Lorena Ayelén , Ortiz Alberto , Paira Sergio 
Published: January 2022

Se comunica una serie de tres casos clínicos que consultaron al servicio de Reumatología por compromiso orbitario y renal. Uno de ellos presentó pseudotumor orbitario con proteinuria en rango nefrótico; se realizó biopsia y se encontró infiltrado linfoplasmocitario denso y fibrosis estoriforme con inmunohistoquímica: 15 células IgG4+ por campo de alto poder y relación IgG/ IgG4 ≤40%, concluyendo diagnóstico de enfermedad relacionada por IgG4.
El segundo y tercer caso presentaron compromiso ocular con "ojos de mapache" y lesiones amarillentas en párpados, ambos con proteinuria >500 mg/24 h, con biopsia de piel rojo Congo positiva y birrefringencia verde manzana con luz polarizada.
Se discuten distintos diagnósticos diferenciales poco frecuentes a tener en cuenta en estos pacientes.
Strategi Pemasaran Produk Tabungan Emas Dalam Upaya Menarik Minat Nasabah pada Pegadaian Syariah Cabang Bogor Baru
Authors: Hasni Fikria , Hamdani Ikhwan , Arif Suyudi 
Published: January 2022

This study aims to explain the marketing strategy in marketing the gold savings products found at Pegadaian Syariah Bogor Baru and how the right strategy is to attract customers to use the Gold Savings product. This research is a field research using a qualitative descriptive approach with primary and secondary data sources. In collecting data, researchers used interviews, observation and documentation techniques. The resource persons of this study were three employees of the Syariah Pawnshop Bogor Baru Branch and two customers of the Gold Savings product. The results of this study indicate that the application of marketing strategies provides services and information that is quite good for customers of gold savings products. From the aspect of the marketing mix contained in the branch office, such as; advertising, personal selling, sales promotion, publicity and direct marketing. Thus, the right strategy is to attract more customers by developing digital technology, this media has been loved by all generations because it can be easily accessed and at any time so that the strategy through digital will be very effective to reach as a whole.
Keywords: marketing strategy, sharia pawnshop, gold savings
Pandemi Covid-19 Mempengaruhi Dampak Pasar Saham di Bursa Efek Indonesia (BEI)
Authors: Purnomo M. Hari , Kartika Cintia Ayu 
Published: January 2022

The purpose of this research is generally to find out, discuss and analyze the COVID-19 pandemic affecting the impact of the stock market in Indonesia on companies listed on the Indonesia Stock Exchange (IDX). This research method uses qualitative methods with data carrying capacity through https://www.idx.co.id/about-bei/laporan-tahunan/ with secondary data techniques, namely by collecting data through online media. The results of this study are that before the pandemic in the last quarter of 2019 there was a decrease in the average daily transaction, while in the last quarter of 2020 stock investors turned positive due to the prospect of covid-19 vaccination, the implementation of work from home led to an increase of 57.92% in average -Average Active Investors per Month, from 186,102 SID (Single Investor Identification) at the end of 2019 to 293,886 SID at the end of 2020. At the close of trading on December 30, 2020 the JCI rebounded to the level of 5,979.
Keywords: the covid-19 pandemic, the impact of the stock market, on the company
Methylglyoxals, Thiocyanate, and Hydrogen Peroxide in saliva of newborns at risk of sepsis: Methylglyoxals as a promising biomarker of early-onset neonatal sepsis
Authors: Yunanto Ari , Gunawan H Pricilia , Suhartono Eko 
Published: January 2022

Introduction. Sepsis represents a severe problem for newborns. The relatively high incidence rate of 1 to 10 cases per 1000 live births, with even higher rates in low-birth-weight neonates. Given its high incidence, identifying markers to optimize the early diagnosis and therapeutic interventions is highly desirable. This study investigates three oxidative markers taken from saliva, methylglyoxal (MG), Thiocyanate (SCN-) and hydrogen peroxide (H2O2), as early-onset neonatal sepsis markers.
Methods. This study was conducted from June to August 2014, and saliva specimens were taken from 30 newborns of mothers with one major risk factor or two minor risk factors (case group) and 30 healthy newborns for the control group. Saliva levels of MG were determined by calculating the percentage of MG absorbance compared with the carbonyl compounds. Data were analyzed by using Kolmogorov-Smirnov and Student's t test.
Results. We found a significant increase of SCN-, and MG level case group (28.91 mmol and 0.01%, respectively) compared to the control group (19.49 mmol and 0.005%, respectively) p-value = 0.03. In contrast, the H2O2 in the case group (32.56 mmol) was lower than the control group (37.47 mmol), with a p-value = 0.04.
Conclusion. We found the increased levels of SCN–, MG and the decreased levels of H2O2 in neonates' saliva with the risk of sepsis. MG measurements as a routine diagnostic for suspected sepsis should be taken into consideration.
VARIÁVEIS FISIOLÓGICAS E MATURAÇÃO SEXUAL EM ESCOLARES PRÉ- PÚBERES E PÚBERES DO SEXO FEMININO DA CIDADE DE SANTA MARIA
Authors: Filipetto Rosângela Kelling 
Published: January 2022

Este trabalho analisou variáveis fisiológicas de meninas pré-púberes (PP) e púberes (P), pertencentes à rede de ensino particular de Santa Maria. A amostra foi formada por 29 escolares femininas de 11,6 anos a 12,6 anos, participantes regulares de educação física escolar. Estudou-se as variáveis fisiológicas de volume de oxigênio máximo (V02max), pressão arterial sistólica e diastólica em repouso e pós exercício (PASr0p, PADrep, PASpe e PADpe), freqüência cardíaca em repouso e pós exercício (FCrep e FCpe), as variáveis antropométricas de massa corporal (Mcorp), estatura (EST) e percentual de gordura corporal (%G) e estágio de desenvolvimento mamário (EDM). Testes foram realizados, tais como, testes antropométricos, teste adaptado de 1000m para espaço reduzido e, além disso, utilizou-se o quadro avaliativo para os estágios de desenvolvimento mamário. Para análi­se, usou-se o teste de Shapiro-Wilk e o pacote estatístico S.A.S.Foram encontradas diferenças estatisticamen­te significativas (p<0,05) entre os grupos PP e P nas variáveis: M , EST, %G e EDM, sendo as médias superi­ores para o grupo P, as demais variáveis não apresentaram diferenças estatisticamente significativas. Através dos dados obtidos concluiu-se que: As púberes possuem maior EDM e valores antropométricos mais elevados. Além disso, não houve diferenças estatisticamente significativas entre as FC, as PASrepe PADrop, PASpe e PADpe e V02max entre os grupos.
CARACTERÍSTICAS FÍSICAS E DESEMPENHO EM CERTOS TESTES FÍSICOS DE JOVENS ATLETAS DE CORRIDA
Authors: Anjos Luiz Antonio dos 
Published: January 2022

Cento e vinte e um partícipantes (81 garotos e 40_ garotas, entre 13 e 19 anos) de um campo de verão (colônia de férias) de treinamento de corridas de fundo foram avaliados usando medidas sim­ples e fáceis de serem tomadas. As variáveis estudadas foram: dobra cutanea (subescapular e tr1cipital), altura, peso corporal, dinamometria manual (din), e corrida de 3 milhas. Essa ultima variável foi também analisada no tempo de corrida da primeira e segunda mi­lhas e meia. Além disso, o nivel de treinamento. (nº de milhas cor­ridas por semana) foi obtido através de questionário respondido pe­los atletas. a percentagem de gordura corporal (% gc) foi calculada a partir dos valores das dobras cutâneas. As médias de cada variável foram comparadas estatisticamente entre sexos. Embora a média de idade dos garotos e garotas fosse a mesma, os garotos eram mais al­tos e pesavam mais que as garotas. A %gc em ambos os grupos foi me­nor do que o valor para a população nao atlética da mesma idade. Os garotos tiveram um valor menor para %gc, correram as 3 milhas num tempo menor, e mostraram valores de DIN maior do que as garotas. Com estes resultados, conclui-se que algumas das características ob­servadas na população não atlética de adolescentes parece não ser a mesma na população de adolescentes envolvidos no esporte. Baseado nisso, sugere-se avaliar jovens atletas utilizando-se para comparação dados normativos obtidos de uma população similar não somente em idade e sexo, mas também praticantes do mesmo esporte.
Trajetória profissional de Jefferson Thadeu Canfield
Authors: Corazza Sara Teresinha 
Published: January 2022

O objetivo desse ensaio é descrever a trajetória profissional de Jefferson Thadeu Canfield, trazendo especialmente detalhes de sua atuação junto ao Centro de Educação Física e Desportos (CEFD) da Universidade Federal de Santa Maria (UFSM. Ele foi pesquisador e professor do CEFD de 1971 a 1996, dedicando-se à área de Aprendizagem Motora. Integrou a Sociedade Brasileira de Comportamento Motor (SOCIBRACOM), tendo sido seu primeiro presidente. Ao aposentar-se dedicou seu tempo livre à fotografia. What do you want to do ?New mailCopy What do you want to do ?New mailCopy What do you want to do ?New mailCopy
Morphometric Study of the Mastoid Process and Notch in Dry Human Skulls
Authors: Blessy Sheron , Mohanraj Karthik Ganesh 
Published: January 2022

Introduction: Mastoid process is a pyramidal bony projection . It is located in the posterior inferior region of the temporal bone. Mastoid notch is on the medial side of the mastoid process. Clinical significance causing infection of the middle ear could spread to the mastoid area causing mastoiditis. The aim of the study is to determine the morphometric and morphological analysis of mastoid process and mastoid notch in dry human skull and their clinical implication.
Materials and Methods: The present study was taken from the department of Anatomy in Saveetha Dental College and Hospital by taking 72 dry human skulls. Digital vernier caliper was used to measure the mastoid process and mastoid notch of different parameters. The data was measured and analyzed statistically, using paired sample ‘t’ tests.
Results: The present study shows 0.641 significance in the right and left length of the mastoid process which is not significant. Right breadth and left breadth of the mastoid process of 0.007 and mastoid notch of right and left length 0.00 are significant.
Conclusion: It concludes that the mastoid process and mastoid notch have varied significant differences in the dry human skulls. This study will be helpful in mastoid surgeries.
Quasihexagonal Platinum Nanodendrites Decorated over CoS2‐N‐Doped Reduced Graphene Oxide for Electro‐Oxidation of C1‐, C2‐, and C3‐Type Alcohols
Authors: Logeshwaran Natarajan , Panneerselvam Iyyappa Rajan , Ramakrishnan Shanmugam , Kumar Ramasamy Santhosh , Kim Ae Rhan , Wang Yan , Yoo Dong Jin 
Published: January 2022

AbstractThe development of efficient and highly durable materials for renewable energy conversion devices is crucial to the future of clean energy demand. Herein, cage‐like quasihexagonal structured platinum nanodendrites decorated over the transition metal chalcogenide core (CoS2)‐N‐doped graphene oxide (PtNDs@CoS2‐NrGO) through optimized shape engineering and structural control technology are fabricated. The prepared electrocatalyst of PtNDs@CoS2‐NrGO is effectively used as anodic catalyst for alcohol oxidation in direct liquid alcohol fuel cells. Notably, the prepared PtNDs@CoS2‐NrGO exhibits superior electrocatalytic performance toward alcohol oxidation with higher oxidation peak current densities of 491.31, 440.25, and 438.12 mA mgpt–1 for (methanol) C1, (ethylene glycol) C2, and (glycerol) C3 fuel electrolytes, respectively, as compared to state‐of‐the‐art Pt‐C in acidic medium. The electro‐oxidation durability of PtNDs@CoS2‐NrGO is investigated through cyclic voltammetry and chronoamperometry tests, which demonstrate excellent stability of the electrocatalyst toward various alcohols. Furthermore, the surface and adsorption energies of PtNDs and CoS2 are calculated using density functional theory along with the detailed bonding analysis. Overall, the obtained results emphasize the advances in effective precious material utilization and fabricating techniques of active electrocatalysts for direct alcohol oxidation fuel cell applications.
Accurate and sensitive probing of onset of micellization based on absolute aggregation‐caused quenching effect
Authors: He Haisheng , Liu Chang , Ming Jiang , Lv Yongjiu , Qi Jianping , Lu Yi , Dong Xiaochun , Zhao Weili , Wu Wei 
Published: January 2022

AbstractProbing the onset of micellization, or determining the critical micelle concentration (CMC), is of crucial importance while remains to be challenged by growing demand for extraordinary sensitivity and accuracy. Although fluorometry has attracted wide attention owing to its superiority in simplicity and sensitivity over other methods, the presence and fluctuation of background fluorescence of conventional fluorescent probes undermine the accuracy of CMC determination. Herein, a series of novel fluorescent probes without background fluorescence at a concentration below CMC owing to absolute aggregation‐caused quenching (aACQ) are utilized for sensitive and accurate measurement of CMC. The aACQ probes aggregate spontaneously and instantly in an aqueous environment owing to molecular π–π stacking with fluorescence quenching absolutely. Therefore, the absence of background fluorescence at a concentration below CMC clears relevant interference associated with conventional fluorophores. In this study, the new method is applied for versatile surfactants with CMCs ranging from nanomolar to millimolar concentrations, especially copolymers with ultralow CMC. The higher sensitivity and accuracy are highlighted by comparison with conventional probes.
Photothermocatalytic System Designed by Facet‐heterojunction to Enhance the Synergistic Effect of Toluene Oxidation
Authors: Luo Yusheng , Chi Zhili , Zhang Jinlong , Tian Baozhu 
Published: January 2022

AbstractIt is very essential to improve the activity and selectivity of photothermocatalysis (PTC) by tailoring the microstructures of photothermocatalytic materials. Herein, we exploit a facet‐heterojunction strategy to fabricate photothermocatalysts, by which CdS−Au‐{001}BiOCl{110}‐MnOx is constructed by respectively depositing CdS−Au on the {001} facets and MnOx on {110} facets of BiOCl nanosheets. This material exhibits excellent activity for toluene oxidation and near 100 % selectivity from toluene to carbon dioxide under full‐spectrum sunlight irradiation. The conversion rate of toluene under PTC condition is significantly enhanced by 47.5, 1.8 and 1.7 times compared with that of sole PC, TC and the sum of TC and PC. There is a synergistic effect between photocatalysis and thermocatalysis, in which the S‐scheme photocatalyst CdS−Au‐{001}BiOCl produces high‐energy active species to activate toluene and accelerate the cycle conversion of lattice oxygen and oxygen vacancy in MnOx.
Ethical remediation practices addressing values conflicts: A delphi study
Authors: Taylor Rouse Kerrie E. , Doughty Horn Elizabeth A. 
Published: January 2022

AbstractThe purpose of this study was to create concrete, practical recommendations for remediation with students struggling to effectively counsel members of the LGBTQ+ populations as a result of faith‐based values conflicts that are both effective and ethical. A panel of seven experts in counselor education participated in this Delphi study.
Hard Carbon Derived from Graphite Anode by Mechanochemistry and the Enhanced Lithium‐Ion Storage Performance
Authors: Wang Xiaotong , Chen Jingjing , Dong Chenlong , Wang Dajian , Mao Zhiyong 
Published: January 2022

AbstractGraphite is the mainstream anode material for commercial lithium‐ion batteries (LIBs), but the low theoretical capacity (372 mAh g−1) becomes the bottleneck to further increase the energy density of LIBs. Herein, hard carbon derived from graphite with enhanced lithium‐ion storage performance is demonstrated by environmentally friendly and simply mechanochemical method. With the mechanochemical treatment, the commercial graphite transferred into hard carbon materials with controllable morphology and defect density. As an optimal exemplification, the obtained hard carbon serving as anode delivers significantly enhanced lithium storage capacity of 629.8 mAh g−1 at a current density of 0.2 A g−1, which is nearly double of the pristine graphite anode. The enhanced lithium storage performance of hard carbon anode is attributed to the presence of numerous defects induced by mechanochemical process, serving as the active sites to improve capacity during the Li insertion and extraction process. Our work broadens the avenue for graphite anode to further increase the energy density of LIBs.
Multiscale modeling of passive material influences on deformation and force output of skeletal muscles
Authors: He Xiaolong , Taneja Karan , Chen Jiun‐Shyan , Lee Chung‐Hao , Hodgson John , Malis Vadim , Sinha Usha , Sinha Shantanu 
Published: January 2022

AbstractPassive materials in human skeletal muscle tissues play an important role in force output of skeletal muscles. This paper introduces a multiscale modeling framework to investigate how age‐associated variations on microscale passive muscle components, including microstructural geometry (e.g., connective tissue thickness) and material properties (e.g., anisotropy), influence the force output and deformations of the continuum skeletal muscle. We first define a representative volume element (RVE) for the microstructure of muscle and determine the homogenized macroscale mechanical properties of the RVE from the separate mechanical properties of the individual components of the RVE, including muscle fibers and connective tissue with its associated collagen fibers. The homogenized properties of the RVE are then used to define the elements of the continuum muscle model to evaluate the force output and deformations of the whole muscle. Conversely, the regional deformations of the continuum model are fed back to the RVE model to determine the responses of the individual microscale components. Simulations of muscle isometric contractions at a range of muscle lengths are performed to investigate the effects of muscle architectural changes (e.g., pennation angles) due to aging on force output and muscle deformation. The correlations between the pennation angle, the shear deformation in the microscale connective tissue (an indicator for the lateral force transmission), the angle difference between the fiber direction and principal strain direction and the resulting shear deformation at the continuum scale, as well as the force output of the skeletal muscle are also discussed.
Multi‐catalytic Enantioselective Synthesis of 1,3‐Diols Containing a Tetrasubstituted Fluorinated Stereocenter
Authors: Shao Na , Monnier Valérie , Charles Laurence , Rodriguez Jean , Bressy Cyril , Quintard Adrien 
Published: January 2022

AbstractThe enantioselective construction of fluorohydrins featuring a tetrasubstituted stereocenter embedded in complex frameworks represents an important challenge. Herein, we report a multicatalytic strategy enabling the stereoselective preparation of a new type of scaffold containing such a challenging fluorohydrin motif. The sequence is based on an organocatalyzed fluorination of α‐disubstituted aldehydes followed by a diastereoselective copper‐catalyzed decarboxylative aldol reaction. Reduction of the generated β‐hydroxy ketone followed by a Lewis base‐catalyzed kinetic resolution enables the isolation of original fluorinated 1,3‐diols with perfect diastereo‐ and enantio‐control.
Application of Al2O3/water nanofluid as the coolant in a new design of photovoltaic/thermal system: An experimental study
Authors: Zamen Mohammad , Kahani Mostafa , Rostami Behzad , Bargahi Mojtaba 
Published: January 2022

AbstractA new geometry of photovoltaic/thermal (PVT) system is introduced in this study, and the application of Al2O3/water nanofluid as the coolant on the electrical and thermal behavior of a solar system is experimentally evaluated. To intensify the thermal ability of the solar collector, a serpentine half‐pipe cooling system is designed and fabricated behind the solar panel for better cooling. The cells of the panel are assembly on a 3‐mm‐thick aluminum plate, and the Tedlar removes from the system to maximize the heat transfer in the cooling section. A special layer arrangement for the composite panel is used to minimize thermal resistance of the system. Different concentrations of nanofluid samples (0.05–0.5 wt.%) prepared. To increase the stability of prepared nanofluids, suitable surfactants are also used. Based on the obtained results, adding the nanoparticles to the pure water can remarkably raise the efficiency of the PVT apparatus. The best behavior of the solar collector is observed for 0.5 wt.% of nanofluid samples. 126.71% and 7.38% enhancement in terms of thermal and electrical efficiency can be gained by the application of nanofluid in the system compared with pure water, respectively. The best obtained value of the overall efficiency is around 93.73% for the studied system. The maximum temperature rise for water and nanofluid is around 5.5 and 9.1°C, respectively, which confirms the better cooling ability of PVT system by nanofluid compared with water.