bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytoreductive treatment and association with platelet function and maturity in patients with essential thrombocythaemia
Authors: Pedersen Oliver Buchhave , Grove Erik Lerkevang , Pasalic Leonardo , Ommen Hans Beier , Kristensen Steen Dalby , Hvas Anne‐Mette 
Published: June 2022

SummaryPatients with essential thrombocythaemia (ET) have an increased risk of thromboembolic events, which may differ according to different cytoreductive drugs. We investigated the effect of cytoreductive treatment on platelet function and turnover in ET patients. Blood samples were obtained at 1 and 24 h after aspirin intake. Platelet function was evaluated by platelet aggregation and flow cytometry. Platelet turnover was assessed by immature platelet count, immature platelet fraction (IPF) and mean platelet volume (MPV). A total of 47 ET patients were included and grouped into 21 patients not receiving cytoreductive treatment, 15 patients receiving hydroxycarbamide and 11 patients receiving pegylated interferon alpha (peg‐IFN). Patients receiving peg‐IFN had significantly higher IPF and MPV than the other ET groups. Patients not receiving cytoreductive treatment had significantly higher platelet aggregation 24 h after aspirin intake than the other ET groups (p‐values from 0.03 to 0.0002). Patients receiving hydroxycarbamide had significantly higher expression of platelet granule makers, P‐selectin and CD63, than patients receiving peg‐IFN (p‐values ≤0.003). Cytoreduction provides more consistent platelet inhibition compared with no cytoreductive treatment. Moreover, peg‐IFN provides superior inhibition of platelet activation markers than hydroxycarbamide, which in part may explain differences in risk of thromboembolic events in ET patients.
Prognostic value of 24‐hour ambulatory blood pressure patterns in diabetes: A 21‐year longitudinal study
Authors: Chiriacò Martina , Sacchetta Luca , Forotti Giovanna , Leonetti Simone , Nesti Lorenzo , Taddei Stefano , Natali Andrea , Solini Anna , Tricò Domenico 
Published: June 2022

AbstractAimsTo establish the long‐term prognostic value of abnormal circadian blood pressure (BP) patterns in diabetes.Materials and MethodsWe retrospectively examined a cohort of 349 outpatients with diabetes who were screened for microvascular complications and followed up for 21 years. Dipping, nondipping and reverse‐dipping status were defined based on 24‐hour ambulatory BP monitoring (ABPM) as ≥10% reduction, <10% reduction, and any increase in average nighttime versus daytime systolic BP (SBP), respectively.ResultsAfter 6251 person‐years of follow‐up (median [range] follow‐up 21.0 [1.1‐22.0] years, 52% women, age 57.1 ± 11.9 years, 81.4% type 2 diabetes and 18.6% type 1 diabetes), a total of 136 deaths (39%) occurred. Compared with dippers, the nondippers and reverse dippers showed progressively higher prevalence of chronic kidney disease (CKD), cardiac autonomic neuropathy (CAN) and postural hypotension. Reverse dippers showed a 13.4% (2.5‐year) reduction in mean overall survival and a twofold increased risk of all‐cause mortality after adjustment for traditional risk factors (hazard ratio 2.2 [95% confidence interval 1.3‐3.8]). Each 1% decrease in nighttime versus daytime SBP ratio was independently associated with a 4% reduction in 20‐year mortality risk.ConclusionsIn patients with diabetes, reverse dipping is associated with a higher prevalence of CKD and CAN and more than doubled the adjusted risk of all‐cause mortality over a 21‐year observation.
Asset bubbles, unemployment, and financial market frictions
Authors: Hashimoto Ken‐ichi , Im Ryonghun , Kunieda Takuma , Shibata Akihisa 
Published: June 2022

AbstractWe develop a tractable infinite horizon model of bubbles and unemployment. Our theoretical analysis proves that bubbles stimulate capital accumulation, reduce unemployment, and increase consumption. We then numerically investigate the impacts of credit constraints, labor market conditions, and redistribution policy on capital accumulation, unemployment, and welfare. Our numerical investigations show that the social welfare in the bubbly steady state is always greater than that in the bubbleless steady state even under the constrained‐optimal policy that neutralizes externalities inherent in the model. Furthermore, we find that bubbles increase welfare to a greater extent in an economy with stricter credit constraints.
Treatment of COVID‐19‐induced refractory status epilepticus by tocilizumab
Authors: Kizilkilic Esra Kochan , Unkun Rumeysa , Uygunoglu Ugur , Delil Sakir , Ozkara Cigdem 
Published: June 2022

AbstractBackground and purposeCOVID‐19 is a novel infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in which neurological complications have been increasingly recognized. Acute symptomatic epileptic seizures and status epilepticus are frequently reported neurological complications associated with this infection. The nervous system damage caused by SARS‐CoV‐2 may be mediated by the immune system. Interleukin 6 (IL‐6), an important component of the cytokine storm, is directly correlated with the severity of symptoms. Tocilizumab is an inhibitor of IL‐6 receptors, which blocks IL‐6‐mediated signal transduction and is used in the treatment of COVID‐19 and status epilepticus.Case reportA patient with the Unverricht–Lundborg disease is presented who had developed refractory recurrent status epilepticus during COVID‐19 infection, which was finally controlled by treatment with tocilizumab.DiscussionTocilizumab, an IL‐6 inhibitor, may be considered as a treatment option in patients with status epilepticus and refractory seizures.
Risk factor management matters more than pharmaceutical cyclooxygenase‐2 inhibition in the prevention of de novo intracranial aneurysms
Authors: Räisänen Sari , Huttunen Jukka , Huuskonen Terhi J. , von und zu Fraunberg Mikael , Koivisto Timo , Jääskeläinen Juha E. , Lindgren Antti , Frösen Juhana 
Published: June 2022

AbstractBackground and purposePathophysiological studies of saccular intracranial aneurysm (sIA) disease have shown that inflammation plays a crucial role in sIA development. Pharmaceutical inhibition of COX‐2–PGE2–NF‐κB signaling (COX‐2, cyclooxygenase‐2; PGE2, prostaglandin E2; NF‐κB, nuclear factor κB) has been shown in animal models to inhibit sIA formation and progression suggesting that use of medication inhibiting COX‐2 could reduce intracranial aneurysm formation also in patients.MethodsThe impact of COX‐2 inhibition on de novo sIA formation was studied in two cohorts: in a previously described angiographically followed cohort of 1419 sIA patients and in a cohort of 117 sIA patients treated with stenting or stent‐assisted embolization. Patients were identified from our population‐based Kuopio Intracranial Aneurysm Database. Data on the use of anti‐inflammatory medications and hospital diagnoses were obtained from national registries. Risk factors were identified by univariate and multivariate analyses.ResultsDe novo sIA patients were younger and more often smokers. Use of COX‐2 selective inhibitors or nonsteroidal anti‐inflammatory drugs did not significantly reduce de novo sIA formation, but the percentage of patients with de novo sIA formation was smaller in patients with prescribed regular acetylsalicylic acid medication (1.1% vs. 3.6%). In the multivariate analysis, however, neither acetylsalicylic acid use nor other type of pharmaceutical inhibition of COX‐2 reduced the formation of de novo sIAs. The risk was mostly affected by age, smoking history and irregular usage of antihypertensive medication regardless of used COX‐2 inhibition level.ConclusionFor the prevention of de novo sIA formation, risk factor management with focus on cessation of smoking and treating hypertension adequately seems more important than pharmaceutical COX‐2 inhibition.
Otopathy secondary to trigeminal schwannoma in a Quarter Horse
Authors: Lemonnier Louise C. , Dorso Laetitia , Tricaud Cyril , Fusellier Marion , Leroux Aurelia A. 
Published: June 2022

SummaryOtitis media secondary to trigeminal nerve (CN‐V) paralysis is described in dogs and humans but not in horses. An 18‐month‐old Quarter Horse colt was presented with history of mastication difficulties and a nonhealing corneal ulcer. Clinical findings were consistent with paralysis of the right CN‐V. Computed tomography imaging showed otopathy media and a mass at the root of the CN‐V. The colt was euthanised due to poor prognosis. Post‐mortem magnetic resonance imaging showed enlargement of the right CN‐V which was slightly hyperintense on T2W. Histopathology of the mass revealed fusiform tumoural cells, positive on vimentin‐ and S100 immunohistochemistry, consistent with a schwannoma. Otitis media was presumed secondary to CN‐V paralysis and denervation of the right tensor veli palatini muscle involved in opening of the Eustachian tube. This is the first case of trigeminal schwannoma and secondary otopathy media described in a horse, which highlights the importance of imaging in investigating trigeminal nerve paralysis.
Warming climate impacts on production dynamics of southern populations of Pacific salmon in the North Pacific Ocean
Authors: Kaeriyama Masahide 
Published: June 2022

AbstractThis study reviews the evidence for warming climate impacts on ocean migration, growth, and survival of southern populations of Pacific salmon (Oncorhynchus spp.), in particular, Japanese chum salmon (O. keta). In this century, productivity of Asian and North American Pacific salmon declined in southern areas but increased in northern areas owing to a warming climate. Japanese chum salmon, mainly hatchery‐produced fish, are roughly divided into two populations: warm‐current populations (WCPs) affected by the Tsushima warm current and cold‐current populations (CCPs) affected by the Oyashio cold current. Their population size and survival rate have declined in Honshu since the late 1990s and in Hokkaido since the late 2000s. The decrease in population size of CCPs is greater than that of WCPs, suggesting that WCPs are relatively adaptable to global warming. A decline in survival rate and insufficient growth of juveniles in coastal habitats due to a shortened duration of coastal stay as a consequence of global warming was identified as the factor affecting the reduced production of Japanese chum salmon. The current situation of chum salmon is approaching that of the Jomon transgression period in Japan (7–5.5 kyr before present). Therefore, it is necessary to establish sustainable conservation management for southern populations of Pacific salmon under a warming climate regime.
Qualitative study of the perspectives of women with lived experience of domestic and family violence on accessing healthcare
Authors: Hollingdrake Olivia , Saadi Noor , Alban Cruz Angelica , Currie Jane 
Published: June 2022

AbstractAimsTo explore the perceptions of women with lived experience of domestic and family violence on accessing healthcare and to identify how nurses can facilitate and support women experiencing domestic and family violence to receive the care they need.DesignA qualitative single site study.MethodsAs part of an evaluation of a nurse‐led domestic and family violence service, a 2‐h focus group was conducted with four women with lived experience of domestic and family violence on 14 December 2021. The Levesque Framework provided a novel approach to identify barriers and facilitators to healthcare access. The focus group guide included eight open‐ended questions. The audio recording was transcribed and analysed using Braun and Clark's thematic analysis process.ResultsThe Levesque Framework helped highlight individual and structural challenges in accessing healthcare faced by women experiencing domestic and family violence. Dominant themes were first contact, comprehensiveness of services and domestic violence awareness.ConclusionThe growing incidences of domestic and family violence are confounding communities worldwide. Despite the high profile of domestic and family violence in Australia, access to healthcare remains problematic. These preliminary findings suggest that nurses have opportunities to facilitate access in relation to the approachability, acceptability and appropriateness of services. Realizing these opportunities requires education that enables nurses' capacity to provide an effective first contact and facilitate comprehensive care by embodying a no wrong door culture. We intend to explore these concepts in future focus groups.ImpactThis study explored the factors impacting access to healthcare for women experiencing domestic and family violence. Accessing healthcare when experiencing domestic and family violence in Australia is problematic. Findings suggest that nursing has opportunities to facilitate the approachability, acceptability and appropriateness of services. These findings will be valuable to nurses across all healthcare settings, nursing education providers and health workforce planners.
The privileged liberal principle‐implementation gap: How the personal behavior of privileged liberals contributes to social inequality
Authors: Glasford Demis E. 
Published: June 2022

AbstractMuch of the work on the development and maintenance of group inequality has focused on a select number of advantaged groups, resulting in a “blind spot” regarding the role of liberals in contributing to social inequality. The present work tests for a privileged liberal principle‐implementation gap, the notion that under conditions that make personal stake salient privileged liberals exhibit a gap between their self‐reported principles and behavioral tendencies. The studies focus on three areas critical to inequality: employment (i.e., affirmative action; Studies 1a and 4), education (i.e., equal access to education for the working class; Study 1b), and housing (i.e., access to affordable housing; Study 1c), as well as support for the homeless (Studies 2 and 3). The results demonstrate that privileged liberals report higher principles to reduce inequality compared to conservatives, but in settings with salient personal stake exhibit no differences in behavior compared to conservatives. The findings also provide direct experimental evidence for the role of personal stake in shaping the privileged liberal P‐I gap. Implications for the study of inequality and impact on Black/Brown working‐class communities, as well as a class‐based approach to social change, are discussed.
Varying frequency of vateritic otoliths in the Baltic herring Clupea harengus membras
Authors: Mäkinen Katja , Rajasilta Marjut , Mäkilä Ermei , Jokinen Sami , Hänninen Jari 
Published: June 2022

AbstractWe report observations of vateritic crystallization in the sagittal otoliths of the Baltic herring Clupea harengus membras in the northern Baltic Sea. While the existence of vaterite in the calcium carbonate matrix of sagittal otoliths has been observed in various species globally, reports from the brackish Baltic Sea are few in number. Large variation in the frequency of vaterite in 1984, 1988, 1997, 2010 and 2017 was observed, suggesting that the phenomenon is not static and more long‐term studies should be conducted in search of the ultimate causing factors.
Impact of paternal body mass index on assisted reproduction treatment outcomes: An updated systematic review and meta‐analysis
Authors: Zhang Xiaofen , Xie Limin , Liu Hairong , Li Wei 
Published: June 2022

AbstractAimThe aim was to provide updated evidence on the association of male body mass index (BMI) with outcomes of assisted reproduction technology (ART).MethodsPubMed, Embase, and Scopus databases were systematically searched. The review included observational studies in patients undergoing ART, that is, either in‐vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) and compared rate of clinical pregnancy and live birth based on different categories of male BMI. Quality of the pooled findings was assessed using the GRADE criteria.ResultsA total of 19 studies were included in the review. Among subjects undergoing IVF, there were no significant differences in the rates of clinical pregnancy among overweight (odds ratio [OR] 1.38, 95% confidence interval [CI]: 0.65, 2.96) and obese (OR 1.86, 95% CI: 0.75, 4.58) BMI, compared to normal male BMI. Similarly, there were no significant differences in the rates of live birth among overweight (OR 1.04, 95% CI: 0.97, 1.13) and obese BMI (OR 0.90, 95% CI: 0.69, 1.18) when compared to males with normal BMI. Further, among those undergoing ICSI, there were no significant differences in the odds of clinical pregnancy among overweight (OR 0.98, 95% CI: 0.73, 1.33) and obese (OR 0.89, 95% CI: 0.62, 1.29). The odds of live births among overweight (OR 0.97, 95% CI: 0.89, 1.05) and obese (OR 0.95, 95% CI: 0.84, 1.07) male BMI were statistically similar to males with normal BMI undergoing ICSI.ConclusionsThe low to very low‐quality findings suggest no significant association of overweight and obese BMI with clinical pregnancy and live birth rates among couples undergoing either IVF or ICSI.
Chronic kidney disease (CKD) and chronic kidney insufficiency (CKI) diagnosing equation in cirrhotic patients
Authors: Musso Carlos G. , Casciato Paola , Macías‐Nuñez Juan , Ardanuy Ramón , Gonzalez‐Torres Henry , Aroca‐Martinez Gustavo , Torres‐Caro Cristina , Narvaez Adrian , Bonifacio Mariano , Padilla Marlene , Gadano Adrian 
Published: June 2022

AbstractCirrhotic patients can develop acute kidney injury (AKI), and chronic kidney disease (CKD). Therefore, renal functional evaluation is crucial in cirrhotic patients. However, serum creatinine and urea levels, as well as measured or estimated glomerular filtration rate is not reliable renal functional markers in these patients compared to other patient groups. In the present study, four original equations are designed and tested for screening chronic kidney disease (CKD) and chronic kidney insufficiency (CKI) in stable cirrhotic patients.Material & Methodestimated GFR (CKD‐EPI creatinine and cystatin equations) were recorded in 175 adult stable patients suffering from cirrhosis, and these patients were classified as presenting or not CKD and CKI after evaluation by two independent nephrologists. Based on these data, the variables with the significant discriminating capability to identify CKD and CKI (based on creatinine and cystatin) were detected by applying the Student's t‐test for two independent groups, later confirmed by the lambda test of Wilks, in order to obtain the renal function equations.Results
CKD equation (creatinine) = 7.094238–0.043104 × CKD‐EPI creatinine ‐ 0.057537 × haematocrit.
CKD equation (cystatin) = 8.375074–0.117218 × CKD‐EPI cystatin.
CKI equation (creatinine) = 0.428389–0.043214 × CKD‐EPI creatinine +0.183051 × Child‐Pugh score + 0.050162 × age (in years).
CKI equation (cystatin) = 9.169579–0.139319 × CKD‐EPI cystatin.
ConclusionSimple and reliable equations have been obtained for screening chronic kidney disease and chronic kidney insufficiency in cirrhotic patients.
Failure of Posterior Lower Lumbar/Lumbosacral Hemi‐Vertebra Resection: An Analysis of Reasons and Revision Strategies
Authors: Liu Dun , Shi Benlong , Li Yang , Liu Zhen , Sun Xu , Zhu Zezhang , Qiu Yong 
Published: June 2022

ObjectiveTo investigate the causes of failed primary surgery and the revision strategies for congenital scoliosis (CS) patients with lower lumbar/lumbosacral (LL/LS) hemi‐vertebra (HV).MethodsFifteen CS patients with LL/LS HV (seven females and eight males) with a mean age of 20.4 ± 10.4 years undergoing revision surgery in our center were retrospectively reviewed. The radiographic parameters including Cobb angle, distance between C7 plumb line and center sacral vertical line (C7PL‐CSVL), thoracic kyphosis (TK), lumbar lordosis (LL) and sagittal vertical axis (SVA) were assessed at pre‐revision, post‐revision and the last follow‐up. The causes of failure in primary operation, and radiographic and clinical outcomes of revision procedures were analyzed.ResultsThe revision rate of patients undergoing LL/LS HV resection and correction surgery was 11.4%. The average time interval between primary surgery and revision surgery was 18.2 ± 10.6 months. The operation duration and estimated blood loss of revision surgery were 194 ± 56 min and 326 ± 74 ml, respectively. Reasons for failed primary operations were as follows: internal fixation fracture in 10 cases, curve progression in two cases, implant loose in two cases and post‐operative coronal imbalance in one case. The post‐revision Cobb angle was significantly improved from 29.9° ± 8.3° to 18.7° ± 6.7° (P < 0.001) with a correction rate of 37.5% ± 12.6%. At the final follow‐up, the average Cobb angle was 18.9° ± 6.2° and the correction was well maintained (P = 0.788). The C7PL‐CSVL at pre‐revision, post‐revision and at last follow‐up were 23.2 ± 9.3 mm, 14.8 ± 4.8 mm and 14.9 ± 5.4 mm, respectively. Significant improvements (P = 0.004) were observed after revision surgery and there was no evident loss of correction (P = 0.703). There was no significant difference in TK, LL and SVA before and after revision surgery (all P > 0.05). At the last follow‐up, no significant correction loss of above coronal and sagittal parameters were observed (all P > 0.05). The revision methods were individualized according to the primary surgical procedures and the reasons for revision. The recommended revision strategies include incision of pseudarthrosis with sufficient bone graft, fixation of satellite rods, thorough residual HV excision, prolonged fusion to S2 and transforaminal lumbar interbody fusion at lumbosacral region. Solid bony fusion and no implant‐related complication were detected during the follow‐up.ConclusionsThe causes of revision surgery for patients with congenital scoliosis (CS) due to lumbosacral HV were verified and implant failure with pseudarthrosis was the main reason for failed primary operation.
Infantile Stevens Johnson syndrome and toxic epidermal necrolysis: A systematic review of clinical features and outcomes in children ages 12 months and under
Authors: Iriarte Christopher , Karim Sabrina A. , Nassim Janelle S. , Grenier Pierre‐Olivier , Massey Krystal Jones 
Published: June 2022

AbstractBackground/ObjectivesStevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life‐threatening mucocutaneous hypersensitivity reactions that carry significant morbidity and mortality. While clinical features are well documented in adult and pediatric patients, infantile cases are rarely reported. Our objective was to synthesize clinical features and outcomes in this population.MethodsA literature search was performed from three large databases (PubMed, EMBASE, and Web of Science) to systematically identify reports of SJS/TEN in the infantile period (defined as less than 12 months of age) between 1962 and 2019. Cases determined to represent SJS/TEN based on defined criteria were included. Each case was scored based on Quality Rating Scheme for Studies and Other Evidence. The initial search yielded 4856 publications, of which 19 (n = 26) met final inclusion criteria.ResultsAll cases for which body surface area (BSA) involvement was available or able to be approximated (n = 18/26) met criteria for TEN. All cases (n = 26) had mucous membrane involvement, with the oral mucosa most commonly affected (85.7%). Mortality was high within our population with 39.1% of infants expiring, 77.8% secondary to bacterial sepsis. The most common triggers were medications (52.4%), infections (33.3%), and vaccinations (14.3%).ConclusionsThis review highlights several unique clinical findings amongst infants with SJS/TEN, including increased BSA involvement, higher rates of bacterial sepsis, and higher mortality rates compared to older children and adults. Infants are more likely to present as TEN over SJS. More research is needed to identify triggers, successful treatments, and specific outcomes in this population.