bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effective Multicast Routing Protocol for Ad Hoc Network
Authors: Shrawankar Urmila 
Published: April 2022

Abstract
Ad-hoc Networks uses multicast routing protocols which generally depend on creation of multicast tree for the transmission of packet from source to destination. It leads to maintain states of the neighboring node, makes it ineffective and incurs more cost. Maintaining the states of nodes also increases communication and processing overhead as well as requires more amount of memory. Almost all protocols maintain the path list in their routing table which also increases overhead while routing the packets. To overcome the problem of increased communication and processing overhead, a Stateless Receiver-Based multicast routing protocol is used that includes a list of the multicast destination member’s addresses, added in packet headers, to enable receivers to decide the best way to forward the multicast traffic.
Use of areca-nut husk ash (AHA) in brick preparation and its impact analysis
Authors: Sharma Subrahmanya R , S Sanjay S 
Published: April 2022

Abstract
Varieties of wastes were used in the preparation of bricks by mixing them in calculated proportions along with soil/clay. Bricks are prepared by the use of wastes such as, wood saw dust and ashes, bamboo ashes, rice husk ash, sugarcane bagasse ash, charcoal, sludge, waste glass powder, plastics, fly ash, mining fluid wastes, petroleum refining wastes, textile wastes, sewage sludge etc. The areca-nut husk is available in plenty as a local excess waste, which is burnt to ash in the furnace. The areca-nut husk ash (AHA) comprises rich content of silica in it, hence mixed with clay in various ratios to prepare the ash based class II bricks. Interestingly bricks prepared had exhibited very low water absorption ability and had superior compression strength. Present invention provides a sustainable waste ash management pathway by making use of AHA to produce the essential construction materials.
From Experimental Results To Business Strategies: Harnessing The Power Of Decision Trees And Rule-Learners
Authors: Pasha Fahad Mansoor 
Published: April 2022

Abstract
Marketing research is considered impractical and theoretical. Marketing research relies on complex models and theoretical concepts that require complex knowledge to understand. However, practitioners (e.g., managers, strategic planners) do not possess complex knowledge. The current study proposes that marketers communicate study results in non-complex, easily understandable language. The current study identifies decision rules and rule-learners as two techniques that marketing researchers can use to communicate study results in easily understandable language. Decision trees and rule-learners transform study results into rules (e.g., if-else statements) that help practitioners adopt strategies based on study results. Using data from two real markets, the current study shows that rule-learners produce more accurate rules (i.e., higher strategic accuracy), while the decision trees create more diversified rules (i.e., greater strategy options). Hence, the decision trees and rule-learners must be combined to produce optimal gains for practitioners using marketing study results. Future research and implications are discussed.
DOMINASI BRAND MINDED DAN MULTI-BRAND LOYALTY DALAM PEMBELIAN PRODUK DENGAN LUXURY BRAND
Authors: Shidiqy Dhiya'u , Setiawan Rendi 
Published: April 2022

Abstrak: The purpose of this study was to determine the dominance of the influence of brand minded and multi-brand loyalty on product purchasing decisions with luxury brands. The population in this study are young entrepreneurs who are members of the Indonesian Young Entrepreneurs Association (HIPMI) Tulungagung. The sample measurement guidelines use the saturated sample technique with a sample of 53 people. The research instrument for data collection in this study used a questionnaire with a Likert scale with data analysis techniques in this study, including descriptive statistical techniques, inferential statistical analysis with classical assumption tests, as well as hypothesis testing with F test and t test with SPSS 23 application. Results The t-test in this study shows that brand mindedness has a positive and significant effect on purchasing decisions for products with luxury brands. Meanwhile, multi-brand loyalty has no effect on respondents' interest in their decision to purchase products with luxury brands. The results of the F test in the study prove that simultaneously brand minded and multi-brand loyalty have an influence on product purchasing decisions with luxury brands.
Kata Kunci: brand minded; multi-brand loyalty; luxury brand

Abstract: Tujuan penelitian ini untuk mengetahui dominasi pengaruh brand minded dan multi-brand loyalty terhadap keputusan pembelian produk dengan luxury brand. Populasi pada penelitian ini adalah para pengusaha muda yang tergabung dalam Himpunan Pengusaha Muda Indonesia (HIPMI) Tulungagung. Pedoman pengukuran sampel menggunakan teknik sampel jenuh dengan sampel sejumlah 53 orang. Instrumen penelitian untuk pengumpulan data dalam penelitian ini menggunakan kuesioner dengan skala likert dengan teknik analisis data pada penelitian ini antara lain dengan teknik statistik deskiptif, analisis statistik inferensial dengan uji asumsi klasik, serta pengujian hipotesis dengan uji F dan uji t dengan aplikasi SPSS 23. Hasil uji t pada penelitian ini menunjukkan bahwa brand minded berpengaruh positif dan signifikan terhadap keputusan pembelian produk dengan luxury brand. Sedangkan multi-brand loyalty terbukti tidak berpengaruh terhadap minat responden dalam keputusannya melakukan pembelian produk dengan luxury brand. Hasil uji F pada penelitian membuktikan bahwa bahwa secara simultan brand minded dan multi-brand loyalty memiliki pengaruh terhadap keputusan pembelian produk dengan luxury brand.
Keywords: brand minded; multi-brand loyalty; luxury brand
REALITAS SUBJEKTIF DAN OBJEKTIF AL-QUR’AN DALAM TRADISI MITONI
Authors: Rosa Sabbrina Laila , Bakhri Syamsul 
Published: April 2022

Abstrak:. Artikel ini membahas mengenai realitas subjektif dan objektif Al-Qur’an dalam tradisi mitoni. Penelitian ini termasuk dalam jenis penelitian lapangan dengan teori kontruksi sosial dari Petter L Berger yang menekankan pada makna dan penafsiran bersama yang dikontruksi dalam jaringan masyarakat. Tujuan Penelitian ini untuk mengetahui Realitas Objektif Al-Qur’an dalam tradisi Mitoni dan Realitas Subjektif Al-Qur’an dalam tradisi Mitoni yang ada pada Masyarakat di Kelurahan Gumawang. Metode yang digunakan dalam penelitian ini adalah Kualitatif dengan paradigma Naturalistik dan melalui pendekatan fenomenologi. Pengumpulan data dilakukan dengan cara observasi, wawancara, dan dokumentasi dari sumber data primer dan sumber data sekunder. Sedangkan analisis data dilakukan secara Fenomenologi-Kualitatif. Hasil penelitian ini menunjukkan bahwa Realitas Subjektif masyarakat menganggap tradisi mitoni sangat sakral dan diyakini apabila tidak melakukan dipercayai akan menimbulkan mara bahaya serta menyebabkan kemusyrikan dan termasuk menyembah selain Allah, pemikiran mereka berlandaskaan pada Al-Qur’an QS.Al-maidah:76 telah menjelaskan tidak boleh menyekutukan Allah. Sedangkan Realitas Objektif Masyarakat dalam tradisi Mitoni ini bahwa Tradisi ini sudah terinternalisasi pada masyarakat, selalu dilakukan, dieksternalisasikan, diobjektifikasikan, hingga menjadi hal yang populer dan masih dilakukan dari zaman nenek moyang hingga saat ini.
Kata Kunci: Realitas Subjektif; Realitas Objektif; Al-Qur’an

Abstract: This article discusses the subjective and objective reality of the Qur'an in the mythological tradition. This research is included in the type of field research with the social construction theory of Petter L Berger which emphasizes the shared meaning and interpretation constructed in community networks.The purpose of this study was to determine the subjective reality of the Qur’an in the Mitoni tradition and the subjective reality of the Koran in the Mitoni tradition that existed in the community in the Gumawang Village.the method used in this research is qualitative with naturalistic paradigm and through phenomenological approach.Data was collected by means of observation, interviews, and documentation from primary data sources and secondary data sources.while the data analysis was carried out in a phenomenological-qualitative way. The results of this study indicate that the Subjective Reality of the community considers the mitoni tradition to be very sacred and is believed if not doing it is believed to cause harm and cause polytheism and includes worshiping other than Allah, their thinking is based on the Qur'an QS. Al-Maidah: 76 has explained cannot associate with Allah. Meanwhile, the Objective Reality of the Society in the Mitoni tradition is that this tradition has been internalized in society, always carried out, externalized, objectified, until it becomes a popular thing and is still practiced from the time of the ancestors to this day.
Keywords: Subjective Reality;Objective Reality; Al-Qur’an
Improved Soluble Expression in Escherichia coli and Easily Purified
Recombinant Human Bone Morphogenetic 7-2 Fusion Protein
Authors: Wang Shuai , Lai Min , Cui Yaqian , Fan Hongwei , Huang Kaizong 
Published: April 2022

Background:
Bone morphogenetic protein (BMP) is a cysteine-rich growth factor and
plays a key role in early bone tissue development and bone defect repair. However, the low yield,
high cost and complicated process in BMP significantly limit its clinical application.

Objective:
In this study, we developed an efficient method for soluble expression and preparation of
recombinant human bone morphogenetic 7-2 fusion protein (rhBMP7-2) and determined its
molecular weight and biological activity.

Methods:
The fusion gene for rhBMP-2 and rhBMP-7 was inserted into the pET-ELP expression
vector. Correct DNA sequence was confirmed, the rhBMP7-2-ELP was transformed into
Escherichia coli strain BL21 (DE3), and the rhBMP7-2 was produced in the recombinant E. coli.
Recombinant BMP7-2 purify was identified using Sodium Dodecyl Sulfate Polyacrylamide Gel
Electrophoresis (SDS-PAGE). The cell proliferation and biological activity of rhBMP7-2 were
measured by Cell Counting Kit-8 and Alkaline Phosphatase assay using C2C12 cells, respectively.

Results:
The result of digestion of NdeI, BamHI and XhoI enzymes showed that the rhBMP7-2-ELP
was correctly constructed. The recombinant BMP7-2 was successfully expressed in soluble form;
the purified rhBMP7-2 showed biological activity and significantly promoted cell proliferation and
differentiation in a dose-dependent manner.

Conclusion:
The rhBMP7-2 fusion protein with osteogenic activity was prepared through a lowcost
and time-efficient method. Our preparation method presents the potential to be applied to the
large-scale production of rhBMP7-2 and is expected to play a significant role in clinical treatment.
Diammonium Glycyrrhizinate Preparation for Liver Function Recovery in Chronic
Hepatitis B in China: A Meta-analysis with Trial Sequential Analysis
Authors: Liu Yibo , Guo Wenfang , Li Minhui 
Published: April 2022

Background:
The treatment of chronic hepatitis B (CHB) comprises a global medical problem, and the first-line clinical drugs have obvious shortcomings. The use of the plant extract diammonium glycyrrhizinate (DG) in food and medicine has gradually widened because of its safety and effectiveness. In clinical practice, DG is mainly used for liver-disease treatment, but DG intervention for CHB lacks systematic-based evidence.

Method:
: The included randomized controlled trials were analyzed by comparator and control respectively for alanine aminotransferase (ALT), aspartate transaminase (AST), and total bilirubin (TBIL) levels, hepatitis B virus DNA negative conversion ratio, and total effective rate, and subgroup analysis was conducted for intervention time, intervention dosage form, comparator drug, and combination drug, among others. Trial sequential analysis was used to verify the results.

Result:
DG could effectively reduce ALT, AST, TBIL, and other liver-function indexes and had a definite effect on liver-function recovery. From the beginning of intervention to 3 months, the effect was significantly better than that of conventional treatment. Compared with other drugs, different dosage forms had differences in efficacy, and DG enteric-coated capsules and injections were lower than compound glycyrrhizin and magnesium isoglycyrrhizin. Meanwhile DG capsules had no significant difference with them. Meanwhile, trial sequential analysis of the main results confirmed the reliability of the conclusion.

Conclusion:
To our knowledge, this was the first relatively complete meta-analysis and systematic evaluation of the efficacy of DG intervention for CHB; liver-function recovery was discussed in the context of traditional Chinese medicine thinking, and DG’s therapeutic effect in CHB was defined.
Impacts of COVID-19 in Breast Cancer: From Molecular Mechanism to
the Treatment Approach
Authors: Acco Alexandra , Stipp Maria Carolina , Corso Claudia Rita 
Published: April 2022

Abstract:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already infected
more than 272 million people, resulting in 5.3 million deaths worldwide from COVID-19. Breast
tumors are considered the world’s most commonly diagnosed cancer. Both breast cancer and
COVID-19 share common pathogenic features, represented by inflammatory mediators and the potential
of SARS-CoV-2 replication in metastatic cancer cells. This may intensify viral load in patients,
thereby triggering severe COVID-19 complications. Thus, cancer patients have a high risk of
developing severe COVID-19 with SARS-CoV-2 infection and a higher rate of complications and
death than non-cancer patients. The present review discusses common mechanisms between
COVID-19 and breast cancer and the particular susceptibility to COVID-19 in breast cancer patients.
We describe the effects of chemotherapeutic agents that are used against this cancer, which should
be considered from the perspective of susceptibility to SARS-CoV-2 infection and risk of developing
severe events. We also present potential drug interactions between chemotherapies that are used to
treat breast cancer and drugs that are applied for COVID-19. The drugs that are identified as having
the most interactions are doxorubicin and azithromycin. Both drugs can interact with each other and
with other drugs, which likely requires additional drug monitoring and changes in drug dosage and
timing of administration. Further clinical and observational studies involving breast cancer patients
who acquire COVID-19 are needed to define the best therapeutic approach when considering the
course of both diseases.
Mechanochemical Promoted Heterocycles: A Solvent-free Route to
Triazole Carbohydrates as Glycogen Phosphorylase Inhibitors
Authors: Guesmi Ahlem , Abdulfattah Wesam , Ticha Manel Ben , Algathami Faisal K. , Aouadi Kaiss , Houas Ammar , Khezami Lotfi , Hamadi Naoufel Ben 
Published: April 2022

Aims:
This study aimed to recommend a novel way for the preparation of carbohydrates containing
triazole derivatives.

Background:
Triazoles containing derivatives have numerous biological activities. Ball milling is a fast,
modest, green process with massive potential. One of the greatest interesting applications of this technique
is in the arena of heterocycles.

Objective:
Solvent-free click reactions are facilitated via the activation of copper powder using a ball milling
mechanochemical procedure. An optimization study of parameters affecting the reaction rate, such as
reaction time, size, and milling ball number, has been conducted. Different substrates have been tested using
this adopted procedure considering in all cases, in high yields and purity, the corresponding chiral optically
pure five-membered glycoconjugates containing 1,2,3-triazole.

Method:
Three milling balls of 10 mm in diameter were placed in the milling jar (50 mL; stainless steel). 1
mmol of alkyne, 2 mmol of azide, and 1 mmol of Cu powder (63 mg) were added, respectively, in the presented
order. Milling was assured for 25 min at 650 rpm deprived of solvent.

Result:
The cycloaddition results and the deprotection of the cycloadducts were affected by the selection of
the protective groups. Cleavage of the acetyl protecting groups provided water-soluble triazoles. The four
1,4-di-substituted 1,2,3-triazoles synthesized via deacetylation were tested against glycogen phosphorylase.
The best inhibitor of rabbit muscle glycogen phosphorylase was 2-Amino-3-{2-[1-(3,4,5,6-tetrahydroxytetrahydro-
pyran-2-ylmethyl)-1H-[1,2,3]triazol-4-yl]-ethylsulfanyl}-propionic acid b (Ki = 40.8±3.2 μM).
This novel procedure affords an eco-friendly reaction profile (catalyst-free) affording high yields and short
reaction times.

Conclusion:
In this work, acetyl protective groups were used to the corresponding deprotected watersoluble
triazole analogous to recognizing glycogen phosphorylase inhibitors. Triazole 6a was the most effective
inhibitor of RMGP b with a Ki value of 40.8 μM.
The Utility of Various Pre-anesthetic Medications Based on Type of General
Anesthesia
Authors: Mahmood Adnan Hussein 
Published: April 2022

Background:
Premedication is used prior to surgery to reduce the adverse effects that
might result from general anesthesia.

Objective:
This study was performed to examine the types and utility of various pre-anesthetic agents
in 100 patients aged between 3 and 60 years who were admitted to Baladrooz General Hospital for different
surgical operations during February (winter) and April (spring) 2021.

Methods:
A total of 62 patients received isoflurane, and 7 patients received sevoflurane, both by inhalational
administration. The other 31 subjects were administered Marcaine (bupivacaine) by spinal anesthesia.

Results:
In this study, eight types of pre-anesthetic medication were administered prior to anesthesia,
as follows: hydrocortisone (35 patients), metoclopramide (25 patients), atropine (13 patients), dexamethasone
(12 patients), midazolam (7 patients), morphine (3 patients), ephedrine (3 patients), and fentanyl
(2 patients).
The most commonly used pre-anesthetic agent administered with isoflurane was hydrocortisone (37
patients), while the least used were fentanyl and morphine, which were administered to 3 patients
each. Hydrocortisone was the premedication most often used (6 patients) with isoflurane, followed by
dexamethasone, midazolam, and metoclopramide (5, 2, and 2 patients, respectively). The preanesthetic
agent used most often with sevoflurane was hydrocortisone (6 patients), followed by dexamethasone
(5 patients) and metoclopramide and midazolam (2 patients each). The premedication most
commonly used with bupivacaine was metoclopramide (25 patients), while the least used was midazolam
(2 patients).

Conclusion:
The study showed that several different pre-anesthetic drugs were used prior to anesthetic
agents, which suggests that the selection of a pre-anesthetic drug depends on the risks that might be
incurred when using a specific anesthetic drug.
Integrating Google Trends Search Engine Query Data Into Adult Emergency Department Volume Forecasting: Infodemiology Study
Authors: Trevino Jesus , Malik Sanjeev , Schmidt Michael 
Published: April 2022

Background
The search for health information from web-based resources raises opportunities to inform the service operations of health care systems. Google Trends search query data have been used to study public health topics, such as seasonal influenza, suicide, and prescription drug abuse; however, there is a paucity of literature using Google Trends data to improve emergency department patient-volume forecasting.

Objective
We assessed the ability of Google Trends search query data to improve the performance of adult emergency department daily volume prediction models.

Methods
Google Trends search query data related to chief complaints and health care facilities were collected from Chicago, Illinois (July 2015 to June 2017). We calculated correlations between Google Trends search query data and emergency department daily patient volumes from a tertiary care adult hospital in Chicago. A baseline multiple linear regression model of emergency department daily volume with traditional predictors was augmented with Google Trends search query data; model performance was measured using mean absolute error and mean absolute percentage error.

Results
There were substantial correlations between emergency department daily volume and Google Trends “hospital” (r=0.54), combined terms (r=0.50), and “Northwestern Memorial Hospital” (r=0.34) search query data. The final Google Trends data–augmented model included the predictors Combined 3-day moving average and Hospital 3-day moving average and performed better (mean absolute percentage error 6.42%) than the final baseline model (mean absolute percentage error 6.67%)—an improvement of 3.1%.

Conclusions
The incorporation of Google Trends search query data into an adult tertiary care hospital emergency department daily volume prediction model modestly improved model performance. Further development of advanced models with comprehensive search query terms and complementary data sources may improve prediction performance and could be an avenue for further research.
Effectiveness of Silver Diamine Fluoride for Preventing Occlusal Caries in the Primary Teeth of Preschool Children: Protocol for a Randomized Controlled Trial
Authors: Duangthip Duangporn , He Shuyang , Gao Sherry Shiqian , Chu Chun Hung , Lo Edward Chin Man 
Published: April 2022

Background
Tooth decay is a significant public health problem globally. The caries-arrest effectiveness of 38% silver diamine fluoride (SDF) has been well documented. However, information on the caries-preventive effect of SDF on primary teeth is insufficient.

Objective
The aim of this trial is to investigate the effectiveness of semiannual application of 38% SDF and that of 5% sodium fluoride (NaF) varnish when compared with placebo control for preventing occlusal caries in the primary molars of preschool children over 30 months.

Methods
This 3-arm, parallel design, double-blind, randomized controlled trial involves 791 preschool children. Children are randomly allocated to receive 1 of 3 interventions as follows: Group 1, 38% SDF; Group 2, 5% NaF varnish; and Group 3, placebo control (tonic water). The intervention and dental examination will be carried out every 6 months. A parent-administered questionnaire, including the children’s demographic background and oral health–related behaviors, has been collected at baseline. Follow-up examinations to detect new caries development will be conducted every 6 months by a masked examiner. Caries development will be diagnosed at the cavitation level. Chi-square tests and logistic regression analyses will be adopted. A 2-level logistic regression analysis will be performed to investigate the effects of the study interventions and other potential confounding factors on the development of occlusal caries.

Results
This study was started on September 1, 2020, and the recruitment process ended on September 30, 2021. At present, a total of 791 children are participating in the study. This 30-month clinical trial is expected to be completed in March 2024.

Conclusions
If SDF application is more effective than NaF varnish for preventing caries on occlusal surfaces of primary teeth, it can be a preferred choice for caries prevention in a kindergarten-based program. Results of this trial will provide valuable clinical evidence for the development of oral health strategies and policies on the promotion of child oral health.

Trial Registration
HKU Clinical Registry HKUCTR-2844, https://tinyurl.com/bdhz9yuk; ClinicalTrials.gov NCT05084001, https://clinicaltrials.gov/ct2/show/NCT05084001

International Registered Report Identifier (IRRID)
DERR1-10.2196/35145