bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data streams classification using deep learning under different speeds and drifts
Authors: Lara-Benítez Pedro , Carranza-García Manuel , Gutiérrez-Avilés David , Riquelme José C 
Published: January 2022

Abstract
Processing data streams arriving at high speed requires the development of models that can provide fast and accurate predictions. Although deep neural networks are the state-of-the-art for many machine learning tasks, their performance in real-time data streaming scenarios is a research area that has not yet been fully addressed. Nevertheless, much effort has been put into the adaption of complex deep learning (DL) models to streaming tasks by reducing the processing time. The design of the asynchronous dual-pipeline DL framework allows making predictions of incoming instances and updating the model simultaneously, using two separate layers. The aim of this work is to assess the performance of different types of DL architectures for data streaming classification using this framework. We evaluate models such as multi-layer perceptrons, recurrent, convolutional and temporal convolutional neural networks over several time series datasets that are simulated as streams at different speeds. In addition, we evaluate how the different architectures react to concept drifts typically found in evolving data streams. The obtained results indicate that convolutional architectures achieve a higher performance in terms of accuracy and efficiency, but are also the most sensitive to concept drifts.
Enabling safe passage: predicting river crossing hotspots for a threatened boreal ungulate susceptible to drowning
Authors: Thomas Julie P , Larter Nicholas C , Jung Thomas S 
Published: January 2022

Abstract
Many mammals cross large rivers to access seasonal habitats, yet river crossing behavior is poorly acknowledged or understood. Crossing large rivers is inherently risky, with vessel traffic and flooding events increasing the risk of drowning. We investigated river crossing behavior by threatened bison (Bison bison) in the boreal forest, using data from 11 GPS-collared animals to identify when and where they cross a major river. We used kernel densities of GPS locations to identify crossing hotspots, and developed resource selection function (RSF) models that used habitat characteristics to explain crossing behavior based on a priori hypotheses. We then predicted high-probability crossing areas along a 400-km stretch of river using the best-supported RSF model. Bison regularly crossed the river (x¯ = 8.6 crossings/100 days), particularly during summer months. Model selection results suggested that bison may have chosen river crossing areas that maximized access to forage. Bison preferred to cross the river near islands and areas with high seismic line densities, both of which were likely preferred summer foraging habitats. In addition, islands may have been used as temporary stopovers while crossing the river, or for relief from biting insects. Bison crossed the river where the channel was relatively narrow (x¯ = 400 ± 213 m [SD]) and chose days when river discharge was low, likely to reduce the risk of drowning, exhaustion, or hypothermia. While based on a small sample of collared bison, predictions about high-probability crossing areas may be used to inform mitigation measures aimed at reducing bison drowning caused by vessel traffic, which is expected to increase as resource development expands in the region. Our approach may be informative for identifying river crossing hotspots for other mammals that cross major rivers.
A rare case of a herniated acute appendicitis
Authors: Ujjal Suresh , Kroijer Rasmus 
Published: January 2022

AbstractAcute appendicitis (AA) is the most common cause of acute abdomen worldwide and untreated it can lead to abscess formation, purulent or faeculent peritonitis, sepsis and death. This paper presents a rare case of an AA herniated in a retro-psoas muscle defect, which has not previously been reported in the literature. Our patient’s diagnosis and management was delayed due to the unusual presentation. This case emphasizes the importance to utilize AA scoring algorithms to aid decision-making as they have shown to reduce admissions, optimize the use of diagnostic imaging and reduce negative surgical explorations.
Augustine’s Mature Understanding of John 5:19 and the Doctrine of Inseparable Operations
Authors: Beckwith Carl L 
Published: January 2022

Abstract
Augustine preached on John 5:19 in several anti-Arian works during the second decade of the fifth century. A close examination of his biblical text and trinitarian vocabulary provides sufficient clues to order these works chronologically and to observe the development of his reading of John 5:19. Augustine’s encounter with Latin Homoian arguments in the anonymous Sermo Arrianorum produces his mature understanding of John 5:19. He uses these insights to read other difficult texts on the Son and Holy Spirit in the Gospel of John and to express his mature understanding of the doctrine of inseparable operations.
Intramolecular carbon isotope signals reflect metabolite allocation in plants
Authors: Wieloch Thomas , Sharkey Thomas David , Werner Roland Anton , Schleucher Jürgen 
Published: January 2022

Abstract
Stable isotopes at natural abundance are key tools to study physiological processes occurring outside the temporal scope of manipulation and monitoring experiments. Whole-molecule carbon isotope ratios (13C/12C) enable assessments of plant carbon uptake yet conceal information about carbon allocation. Here, we identify an intramolecular 13C/12C signal at tree-ring glucose C-5 and C-6 and develop experimentally testable theories on its origin. More specifically, we assess the potential of processes within C3 metabolism for signal introduction based (inter alia) on constraints on signal propagation posed by metabolic networks. We propose that the intramolecular signal reports carbon allocation into major metabolic pathways in actively photosynthesizing leaf cells including the anaplerotic, shikimate, and non-mevalonate pathway. We support our theoretical framework by linking it to previously reported whole-molecule 13C/12C increases in cellulose of ozone-treated Betula pendula and a highly significant relationship between the intramolecular signal and tropospheric ozone concentration. Our theory postulates a pronounced preference for leaf cytosolic triose-phosphate isomerase to catalyse the forward reaction in vivo (dihydroxyacetone phosphate to glyceraldehyde 3-phosphate). In conclusion, intramolecular 13C/12C analysis resolves information about carbon uptake and allocation enabling more comprehensive assessments of carbon metabolism than whole-molecule 13C/12C analysis.
The far-infrared/radio correlation for a sample of strongly lensed dusty star-forming galaxies detected by Herschel
Authors: Giulietti M , Massardi M , Lapi A , Bonato M , Enia A F M , Negrello M , D’Amato Q , Behiri M , De Zotti G 
Published: January 2022

Abstract
We investigate the radio-far infrared (FIR) correlation for a sample of 28 bright high-redshift (1 ≲ z ≲ 4) star-forming galaxies selected in the FIR from the Herschel-ATLAS fields as candidates to be strongly gravitationally lensed. The radio information comes either from high sensitivity dedicated ATCA observations at 2.1 GHz or from cross-matches with the FIRST survey at 1.4 GHz. By taking advantage of source brightness possibly enhanced by lensing magnification, we identify a weak evolution with redshift out to z ≲ 4 of the FIR-to-radio luminosity ratio qFIR. We also find that the qFIR parameter as a function of the radio power $L_{1.4\, \rm GHz}$ displays a clear decreasing trend, similarly to what is observed for optically/radio selected lensed quasars found in literature, yet covering a complementary region in the $q_{\rm FIR}-L_{1.4\, \rm GHz}$ diagram. We interpret such a behavior in the framework of an in-situ galaxy formation scenario, as a result of the transition from an early dust-obscured star-forming phase (mainly pinpointed by our FIR selection) to a late radio-loud quasar phase (preferentially sampled by the optical/radio selection).
The role of plasma instabilities in relativistic radiation-mediated shocks: stability analysis and particle-in-cell simulations
Authors: Vanthieghem A , Mahlmann J F , Levinson A , Philippov A , Nakar E , Fiuza F 
Published: January 2022

ABSTRACT
Relativistic radiation-mediated shocks are likely formed in prodigious cosmic explosions. The structure and emission of such shocks are regulated by copious production of electron–positron pairs inside the shock-transition layer. It has been pointed out recently that substantial abundance of positrons inside the shock leads to a velocity separation of the different plasma constituents, which is expected to induce a rapid growth of plasma instabilities. In this paper, we study the hierarchy of plasma microinstabilities growing in an electron-ion plasma loaded with pairs and subject to a radiation force. Linear stability analysis indicates that such a system is unstable to the growth of various plasma modes which ultimately become dominated by a current filamentation instability driven by the relative drift between the ions and the pairs. These results are validated by particle-in-cell simulations that further probe the non-linear regime of the instabilities, and the pair-ion coupling in the microturbulent electromagnetic field. Based on this analysis, we derive a reduced-transport equation for the particles via pitch-angle scattering in the microturbulence and demonstrate that it can couple the different species and lead to non-adiabatic compression via a Joule-like heating. The heating of the pairs and, conceivably, the formation of non-thermal distributions, arising from the microturbulence, can affect the observed shock-breakout signal in ways unaccounted for by current single-fluid models.
A dedicated Lunar Trojan Asteroid Survey with small ground-based telescopes
Authors: Gregg Cole R , Wiegert Paul A 
Published: January 2022

ABSTRACT
A co-orbital asteroid shares the orbit of a secondary body about its primary. Though more commonly encountered as an asteroid that shares a planet’s orbit around the Sun, a co-orbital asteroid could similarly share the orbit of the Moon around the Earth. Though such asteroids would be close to the Earth and so relatively bright, their rapid on-sky motion is such that they might escape detection by near-Earth asteroid surveys. The discovery of such lunar co-orbital asteroids (which we will refer to generically here as Lunar Trojans or LTs) would advance our understanding of inner Solar System orbital dynamics and would provide research opportunities for the growing number of missions slated for cislunar space. No LT asteroids are currently known and the last published survey dedicated to these asteroids was conducted nearly 40 yr ago. It has been theoretically determined that orbits near the Earth–Moon L4 and L5 points could survive for several million years. Although this time-scale is shorter than the lifetime of the Solar System, it introduces the possibility of the temporary capture of asteroids into the LT state. This project aims to observationally evaluate the population of LTs with modern techniques. Using four small ground-based telescopes from the iTelescope network, 8340 deg2 on the sky were surveyed down to 15th mag. Though one fast-moving near-Earth object was detected, no LTs were observed. We deduce an upper limit of ≲5 LTs with H &lt; 26.
Dark energy with oscillatory tracking potential: observational constraints and perturbative effects
Authors: Joseph Albin , Saha Rajib 
Published: January 2022

ABSTRACT
The cosmological models exhibiting tracker properties have great significance in the context of dark energy as they can reach the present value of dark energy density from a wide range of initial conditions, thereby alleviating both the fine-tuning and the cosmic coincidence problem. The α-attractors, which are originally discussed in the context of inflation, can exhibit the properties of dark energy as they can behave like cosmological trackers at early times and show the late-time behaviour of a cosmological constant. In this paper, we study the oscillatory tracker model (OTM), which belongs to the family of α-attractor dark energy models. Using the current observational data sets like cosmic microwave background (CMB), baryon acoustic oscillation, and type 1a supernova data (Pantheon compilation), we constrain the parameters of the model and estimate both the mean and best-fitting values. Although the OTM contains a larger set of parameters than the usual lambda cold dark matter (LCDM) model, the common set of parameters of both agree within $1\, \sigma$ error limits. Our observations using both high redshift and low redshift data support Hubble parameter value H0 = 67.4  Km s−1 Mpc−1. We study the effect of the OTM on the CMB temperature and polarization power spectra, matter power spectrum and fσ8. Our analysis of the CMB power spectrum and matter power spectrum suggests that the oscillatory tracker dark energy model has noticeable differences from usual LCDM predictions. Yet, in most cases, the agreement is very close.
Dysgu: efficient structural variant calling using short or long reads
Authors: Cleal Kez , Baird Duncan M 
Published: January 2022

AbstractStructural variation (SV) plays a fundamental role in genome evolution and can underlie inherited or acquired diseases such as cancer. Long-read sequencing technologies have led to improvements in the characterization of structural variants (SVs), although paired-end sequencing offers better scalability. Here, we present dysgu, which calls SVs or indels using paired-end or long reads. Dysgu detects signals from alignment gaps, discordant and supplementary mappings, and generates consensus contigs, before classifying events using machine learning. Additional SVs are identified by remapping of anomalous sequences. Dysgu outperforms existing state-of-the-art tools using paired-end or long-reads, offering high sensitivity and precision whilst being among the fastest tools to run. We find that combining low coverage paired-end and long-reads is competitive in terms of performance with long-reads at higher coverage values.
Exploring the importance of work outcomes in gynaecological patients
Authors: Sparks R , Ahluwalia S , Aslam I , Austin G , Fitzgerald R , Gupta S , Inyang D , Khan A , Opoka V , Wardere J , Madan I , Naleem S , Parsons V 
Published: January 2022

Abstract

Background
There has been increasing evidence that physicians in gynaecology are not routinely enquiring about work during consultations.

Aims
To explore the effect gynaecological conditions can have on work functioning, the importance of work outcomes among patients and whether work considerations are discussed during clinical consultations.

Methods
A cross-sectional survey was administered to employed patients attending a gynaecological clinic at Guy’s Hospital. The survey assessed four areas: demographics, gynaecological condition (including self-assessed severity), work status and perceived impact of the condition on work functioning and job satisfaction. Simple descriptive analysis and statistical techniques were used to interpret the data.

Results
One hundred and six participants participated (mean age: 37.49 ± 9.09). About 95% found it important to be able to work whilst receiving treatment and 82% of patients had reported at least a slight impact on their working ability due to their condition. Of the 31 patients for whom it was their first appointment, 77% said it would be useful to discuss the possible impacts their gynaecological condition could have on their work. About 66% (19/29) of the participants attending a follow-up appointment reported that their doctor had not discussed their work with them.

Conclusions
The symptoms of gynaecological conditions can impact patients’ ability to work. There is a lack of useful discussion from doctors about the perceived impact gynaecological conditions can have on a patient’s ability to work, despite patients finding it important to be able to remain or return to work.
On the different role of alarm substances and fish kairomones in diapause induction in a freshwater planktonic crustacean
Authors: Więski Kazimierz , Ślusarczyk Mirosław 
Published: January 2022

Abstract
Many aquatic organisms anticipate predation risk via infochemical detection. In a laboratory experiment, we investigated the expression of life-history responses in planktonic Daphnia magna under long-lasting exposure to various concentrations of fish kairomones (FK) and alarm substances of Daphnia (AS).
Daphnia were exposed to one of six concentrations of AS (0, 0.0005, 0.005, 0.05, 0.5, 5 homogenized D. magna/L) mixed with the highest concentration of FK, or to one of six concentrations of FK (diluted fish feces of 0, 0.001, 0.002, 0.01, 0.02, 0.1 fish/L) accompanied by the highest concentration of AS. FK alone at the highest concentration were sufficient to induce diapause in 21% of Daphnia, while AS alone at the highest concentration did not trigger diapause. Mixed at the highest concentrations, both cues induced diapause in 94% of Daphnia, whereas in the control treatment free of infochemicals no ephippial individuals occurred. No significant size or fecundity changes accompanied the diapause response.
The graded type of diapause response observed across a wide concentration AS concentrations suggests that Daphnia use AS concentration as a proxy for the level of non-specific predation risk. In contrast, the abrupt change of diapause response across a narrow concentration of FK suggests that they were more critical to identify predator origin than level of risk.
γ-Aminobutyric acid plays a key role in plant acclimation to a combination of high light and heat stress
Authors: Balfagón Damián , Gómez-Cadenas Aurelio , Rambla José L , Granell Antonio , de Ollas Carlos , Bassham Diane C , Mittler Ron , Zandalinas Sara I 
Published: January 2022

AbstractPlants are frequently subjected to different combinations of abiotic stresses, such as high light (HL) intensity, and elevated temperatures. These environmental conditions pose a threat to agriculture production, affecting photosynthesis, and decreasing yield. Metabolic responses of plants, such as alterations in carbohydrates and amino acid fluxes, play a key role in the successful acclimation of plants to different abiotic stresses, directing resources toward stress responses, and suppressing growth. Here we show that the primary metabolic response of Arabidopsis (Arabidopsis thaliana) plants to HL or heat stress (HS) is different from that of plants subjected to a combination of HL and HS (HL+HS). We further demonstrate that the combined stress results in a unique metabolic response that includes increased accumulation of sugars and amino acids coupled with decreased levels of metabolites participating in the tricarboxylic acid cycle. Among the amino acids exclusively accumulated during HL+HS, we identified the nonproteinogenic amino acid γ-aminobutyric acid (GABA). Analysis of different mutants deficient in GABA biosynthesis (GLUTAMATE DESCARBOXYLASE 3 [gad3]) as well as mutants impaired in autophagy (autophagy-related proteins 5 and 9 [atg5 and atg9]), revealed that GABA plays a key role in the acclimation of plants to HL+HS, potentially by promoting autophagy. Taken together, our findings identify a role for GABA in regulating plant responses to combined stress.
The histone deacetylase 1/GSK3/SHAGGY-like kinase 2/BRASSINAZOLE-RESISTANT 1 module controls lateral root formation in rice
Authors: Hou Jiaqi , Zheng Xueke , Ren Ruifei , Shi Qipeng , Xiao Huangzhuo , Chen Zhenfei , Yue Mengxia , Wu Yequn , Hou Haoli , Li Lijia 
Published: January 2022

Abstract
Lateral roots (LRs) are a main component of the root system of rice (Oryza sativa) that increases root surface area, enabling efficient absorption of water and nutrients. However, the molecular mechanism regulating LR formation in rice remains largely unknown. Here, we report that histone deacetylase 1 (OsHDAC1) positively regulates LR formation in rice. Rice OsHDAC1 RNAi plants produced fewer LRs than wild-type plants, whereas plants overexpressing OsHDAC1 exhibited increased LR proliferation by promoting LR primordia formation. Brassinosteroid treatment increased the LR number, as did mutation of GSK3/SHAGGY-like kinase 2 (OsGSK2), whereas overexpression of OsGSK2 decreased the LR number. Importantly, OsHDAC1 could directly interact with and deacetylate OsGSK2, inhibiting its activity. OsGSK2 deacetylation attenuated the interaction between OsGSK2 and BRASSINAZOLE-RESISTANT 1 (OsBZR1), leading to accumulation of OsBZR1. The overexpression of OsBZR1 increased LR formation by regulating Auxin/IAA signaling genes. Taken together, the results indicate that OsHDAC1 regulates LR formation in rice by deactivating OsGSK2, thereby preventing degradation of OsBZR1, a positive regulator of LR primordia formation. Our findings suggest that OsHDAC1 is a breeding target in rice that can improve resource capture.
Disparities in the prevalence of clinical features between systemic juvenile idiopathic arthritis and adult-onset Still’s disease
Authors: Ruscitti Piero , Natoli Valentina , Consolaro Alessandro , Caorsi Roberta , Rosina Silvia , Giancane Gabriella , Naddei Roberta , Di Cola Ilenia , Di Muzio Claudia , Berardicurti Onorina , Iacono Daniela , Pantano Ilenia , Rozza Gelsomina , Rossi Silvia , De Stefano Ludovico , Balduzzi Silvia , Vitale Antonio , Caso Francesco , Costa Luisa , Prete Marcella , Navarini Luca , Iagnocco Annamaria , Atzeni Fabiola , Guggino Giuliana , Perosa Federico , Cantarini Luca , Frediani Bruno , Montecucco Carlomaurizio , Ciccia Francesco , Cipriani Paola , Gattorno Marco , Giacomelli Roberto , Ravelli Angelo 
Published: January 2022

Abstract

Objective
To compare clinical features and treatments of patients with systemic JIA (sIJA) and adult-onset Still’s disease (AOSD).

Methods
The clinical charts of consecutive patients with sJIA by International League of Association of Rheumatology criteria or AOSD by Yamaguchi criteria were reviewed. Patients were seen at a large paediatric rheumatology referral centre or at 10 adult rheumatology academic centres. Data collected included clinical manifestations, inflammation biomarkers, systemic score, macrophage activation syndrome (MAS), parenchymal lung disease, disease course, disability, death and medications administered.

Results
A total of 166 patients (median age at diagnosis 5 years) with sJIA and 194 patients with AOSD (median age at diagnosis 41 years) were included. The frequency of fever, rash, arthralgia, abdominal pain, MAS, parenchymal lung disease and increased acute phase reactants and ferritin were comparable between the two cohorts. Patients with sJIA had a higher prevalence of arthritis, whereas patients with AOSD had experienced leucocytosis and extra-articular organ involvement more frequently. Patients with AOSD were given more commonly low-dose corticosteroids, whereas biologic DMARDs were administered first-line more frequently in patients with sJIA.

Conclusion
We found remarkable disparities in the prevalence of clinical manifestations between the two illnesses, which may partly depend on their classification by different criteria.