bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomic and neuroimaging approaches to bipolar disorder
Authors: Oraki Kohshour Mojtaba , Papiol Sergi , Ching Christopher R. K. , Schulze Thomas G. 
Published: February 2022

BackgroundTo date, besides genome-wide association studies, a variety of other genetic analyses (e.g. polygenic risk scores, whole-exome sequencing and whole-genome sequencing) have been conducted, and a large amount of data has been gathered for investigating the involvement of common, rare and very rare types of DNA sequence variants in bipolar disorder. Also, non-invasive neuroimaging methods can be used to quantify changes in brain structure and function in patients with bipolar disorder.AimsTo provide a comprehensive assessment of genetic findings associated with bipolar disorder, based on the evaluation of different genomic approaches and neuroimaging studies.MethodWe conducted a PubMed search of all relevant literatures from the beginning to the present, by querying related search strings.ResultsANK3, CACNA1C, SYNE1, ODZ4 and TRANK1 are five genes that have been replicated as key gene candidates in bipolar disorder pathophysiology, through the investigated studies. The percentage of phenotypic variance explained by the identified variants is small (approximately 4.7%). Bipolar disorder polygenic risk scores are associated with other psychiatric phenotypes. The ENIGMA-BD studies show a replicable pattern of lower cortical thickness, altered white matter integrity and smaller subcortical volumes in bipolar disorder.ConclusionsThe low amount of explained phenotypic variance highlights the need for further large-scale investigations, especially among non-European populations, to achieve a more complete understanding of the genetic architecture of bipolar disorder and the missing heritability. Combining neuroimaging data with genetic data in large-scale studies might help researchers acquire a better knowledge of the engaged brain regions in bipolar disorder.
Evaluation of Female Fertility—AMH and Ovarian Reserve Testing
Authors: Cedars Marcelle I 
Published: February 2022

Abstract

Context
Evaluation of the infertile female requires an understanding of ovulation and biomarkers of ovarian reserve. Antimüllerian hormone (AMH) correlates with growing follicles in a menstrual cycle. Increasingly, AMH has been used as a “fertility test.” This narrative review describes how to integrate the use of AMH into diagnosis and treatment.

Methods
A PubMed search was conducted to find recent literature on measurements and use of serum AMH as a marker of ovarian reserve and in treatment of infertility.

Results
Serum AMH estimates ovarian reserve, helps determine dosing in ovarian stimulation, and predicts stimulation response. As such, AMH is a good marker of oocyte quantity but does not reflect oocyte health or chances for pregnancy. Screening of AMH before fertility treatment should be used to estimate expected response and not to withhold treatment. Low AMH levels may suggest a shortened reproductive window. AMH levels must be interpreted in the context of the endogenous endocrine environment where low follicle-stimulating hormone, due to hypogonadotropic hypogonadism or hormonal contraceptive use, may lower AMH without being a true reflection of ovarian reserve. In addition, there is an inverse correlation between body mass index and AMH that does not reflect ovarian response.

Conclusion
AMH is a useful marker of ovarian reserve in reproductive-aged women. Increased screening of noninfertile women requires a thorough knowledge of situations that may affect AMH levels. In no situation does AMH reflect oocyte health or chances for conception. Age is still the strongest driver in determining success rates with fertility treatments.
SARS-CoV-2 Vaccine–induced Thyroiditis: Safety of Revaccinations and Clinical Follow-up
Authors: Oğuz Seda Hanife , Şendur Süleyman Nahit , İremli Burçin Gönül , Gürlek Alper , Erbas Tomris , Ünlütürk Uğur 
Published: February 2022

Abstract

Context
The number of reported cases with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccine–induced subacute thyroiditis (SAT) and Graves’ disease (GD) is growing. However, active debate continues about managing such side effects and the safety of repeat or booster doses of the vaccines in such cases.

Objectives
This study aims to present long-term clinical follow-up of SARS-CoV-2 vaccine–induced SAT or GD cases and provide data regarding the safety of revaccinations.

Methods
Patients diagnosed with SARS-CoV-2 vaccine–induced SAT or GD were included. Data regarding the long-term clinical follow-up of SARS-CoV-2 vaccine–induced SAT and GD cases and outcomes of repeat or booster SARS-CoV-2 vaccinations were documented. The literature, including cases of SARS-CoV-2 vaccine–induced SAT or GD, was reviewed.

Results
Fifteen patients with SARS-CoV-2 vaccine–induced SAT and 4 with GD were included. Pfizer/BioNTech COVID-19 vaccine (BNT162b2) was associated with symptoms in a majority of cases with SAT and all with GD. Median time from vaccination to symptom onset was 7 and 11.5 days, respectively, while 7 and 2 patients required medical treatment in SAT and GD groups, respectively. Remission was documented in 10 SAT patients, with a median time to remission of 11.5 weeks. No exacerbation/recurrence of SAT occurred in 7 of 9 patients who received a repeat vaccination dose, while symptoms of SAT worsened following the second vaccination in 2 cases. None of the patients experienced severe side effects that could be associated with revaccinations.

Conclusions
Revaccinations appear to be safe in patients with SARS-CoV-2 vaccine–induced SAT cases, while more evidence is needed regarding SARS-CoV-2 vaccine–induced GD.
An Approach to the Patient With Delayed Puberty
Authors: Harrington Jennifer , Palmert Mark R 
Published: February 2022

Abstract
Pediatric endocrinologists often evaluate and treat youth with delayed puberty. Stereotypically, these patients are 14-year-old young men who present due to lack of pubertal development. Concerns about stature are often present, arising from gradual shifts to lower height percentiles on the population-based, cross-sectional curves. Fathers and/or mothers may have also experienced later than average pubertal onset. In this review, we will discuss a practical clinical approach to the evaluation and management of youth with delayed puberty, including the differential diagnosis and key aspects of evaluation and management informed by recent review of the existing literature. We will also discuss scenarios that pose additional clinical challenges, including: (1) the young woman whose case poses questions regarding how presentation and approach differs for females vs males; (2) the 14-year-old female or 16-year-old young man who highlight the need to reconsider the most likely diagnoses, including whether idiopathic delayed puberty can still be considered constitutional delay of growth and puberty at such late ages; and finally (3) the 12- to 13-year-old whose presentation raises questions about whether age cutoffs for the diagnosis and treatment of delayed puberty should be adjusted downward to coincide with the earlier onset of puberty in the general population.
Imputation provides an opportunity to study filaggrin (FLG) null mutations in large population cohorts that lack bespoke genotyping
Authors: Paternoster Lavinia , Budu-Aggrey Ashley , Brown Sara J. 
Published: February 2022

Background: Low frequency mutations within the filaggrin (FLG) gene are established genetic risk factors for atopic dermatitis. Studies of FLG have typically used sequencing or bespoke genotyping. Large-scale population cohorts with genome-wide imputed data offer powerful genetic analysis opportunities, but bespoke FLG genotyping is often not feasible in such studies. Therefore, we aimed to determine the quality of selected FLG null genotype data extracted from genome-wide imputed sources, focussing on UK population data. Methods: We compared the allele frequencies of three FLG null mutations (R501X, R2447X and S3247X) in directly genotyped and genome-wide imputed data in the ALSPAC cohort. Logistic regression analysis was used to test the association of atopic dermatitis with imputed and genotyped FLG null mutations in ALSPAC and UK Biobank to investigate the usefulness of imputed FLG data. Results: The three FLG null mutations appear to be well imputed in datasets that use the Haplotype Reference Consortium (HRC) for imputation (0.3% discordance compared with directly genotyped data). However, a greater proportion of null alleles failed imputation compared to wild-type alleles. Despite the calling of FLG mutations in imputed data being imperfect, they are still strongly associated with atopic dermatitis (p-values between 7x10-10 and 5x10-75 in UK Biobank). Conclusions: HRC imputed data appears to be adequate for UK population-based genetic analysis of selected FLG null mutations.
SPECIFICS OF GENERATION Y E-COMMERCE IN SOCIAL NETWORKS
Authors: Yanshina Irina V. 
Published: February 2022

This article examines the main features of media consumption and economic activity of millennials in social networks Facebook Inc., the main patterns of consumer models and sales via social networks.
Purpose: to analyze media and commercial consumption of Generation Y at Facebook Inc social networks over the past decade.
Methods of research: historical, didactic, dialectical research methods, as well as methods of comparative analysis and interviews were used. The object of the research is generation Y or millennials. The topic of the research is the consumer patterns of the considered social group. The objective of the research is to identify the ways how millennials interact with online content, social media as well as to understand the ways and factors of online generation Y consumption.
Results: the main consumer patterns of millennials were identified: more time is needed for interaction between the consumer and the seller, the simultaneous use of several platforms, a better perception of product and brand through mascots and a game format.
Practical implications: the results can be used for further research of the generation of millennials and the theory of generations as well as for practical purposes in the field of marketing and e-commerce.
Matching Level of Clinical Support to Patient Risk When Caring for Children With Behavioral Challenges
Authors: Birkett Kerri , Liddle Melissa , Jones Emily , Paulson Andrea 
Published: February 2022

Abstract
Adaptive care plans (ACPs) are an innovative method to providing care for children and adolescents with developmental disabilities who have challenging behaviors during healthcare encounters. ACPs take a family-centered approach to ensure that children with developmental disabilities are able to receive safe and appropriate healthcare by increasing communication and collaboration between caregivers and healthcare team members. Differing healthcare professionals are strategically involved in order to appropriately match the level of support to the patient's behavioral risk through a review of two case examples from the pediatric physical medicine and rehabilitation department. Specifically, case examples describe varying levels of accommodations and support provided to children with challenging behaviors, whose behaviors may have otherwise prevented them from receiving appropriate health interventions.
Photocatalytic degradation of Rhodamine B in aqueous phase by bimetallic metal-organic framework M/Fe-MOF (M = Co, Cu, and Mg)
Authors: Ngan Tran Thi Kim , Ho Huu Loc , Nguyen Huu Vinh , Tran Bich Thuy , Nguyen Trung Thanh , Thi Bui Phuong Quynh , Bach Long Giang 
Published: February 2022

Abstract
Bimetallic metal-organic frameworks (MOFs) exhibit outstanding performance in a wide range of applications, including gas catalysis, adsorption, and luminescence sensor. The structure and properties of materials can be designed based on the variation of different metal ions, so this MOFs material system has unique properties. In this study, M/Fe-MOF bimetallic materials (M = Co, Cu, and Mg) were synthesized by solvothermal method and evaluated for photocatalytic activity in the degradation reaction of rhodamine B (RhB) organic pigments. The as-synthesized materials were characterized by using several physicochemical methods such as X-ray diffraction, fourier transform infrared spectroscopy (FT-IR), ultraviolet-visible spectroscopy (UV-Vis), Brunauer–Emmett–Teller (BET), scanning electron microscopy (SEM), and UV-Vis diffuse reflectance spectra. The results show that the Co/Fe-MOF, Cu/Fe-MOF, and Mg/MOF materials have uniform grain grade, high crystallinity, with the surface area of 26.1, 25.9, and 25.9 m2/g, respectively. When modified with Co, Cu, and Mg, the crystal structure of Fe-MOF materials was unchanged, and all metal ions are inserted inside the structure of the material, as well as replacing Fe ions in the lattice crystals. At the same time, the modification also increases the light absorption in the visible light region and gives a high photocatalytic degradation of RhB organic pigments under visible light in the range of 85–92%.
High temperature creep deformation of nanocrystalline diamond films
Authors: Mohr Markus , Fecht Hans-Jörg , Padmanabhan Kuppuswamy Anantha 
Published: February 2022

Abstract
Diamond displays a combination of unique properties, including the highest hardness among materials, chemical inertness and high thermal conductivity. Therefore, nanocrystalline diamond films offer a huge potential for industrial applications. In fine-grained ceramics as well as metallic materials, high temperature creep deformation is dominated by grain-boundary-deformation mechanisms that become increasingly important with decreasing grain size. In this work we demonstrate that it is possible to inelastically deform nanocrystalline diamond films at elevated temperatures and stresses that are significantly lower than those reported for single-crystal diamond. The initial, isothermal, transient creep flow exhibits a logarithmic character, typical of creep in general. The isothermal steady state creep deformation, which follows transient creep, is analyzed using a physics-based model for grain boundary sliding rate controlled flow.
Diversity in representing space within and between language communities
Authors: Lum Jonathon , Palmer Bill , Schlossberg Jonathan , Gaby Alice 
Published: February 2022

AbstractFew areas of cognition are as fundamental to our lives as representing physical space. However, the way languages represent space varies widely, as does non-linguistic spatial behavior. Research on spatial language casts light on the relationship between language and conceptual structure, and across linguistic and non-linguistic modalities. Most research in this domain treats languages as individual data points, typologizing them on the basis of, for example, preferred frame of reference, such as the egocentric viewpoint-based relative FoR (terms likeleftandright), versus a geocentric or absolute FoR (terms likenorthandsouth). The papers in this special collection demonstrate that considerable variation exists in spatial languagewithinas well as between language communities, and that a diverse array of factors interacts to drive this variation, from terrain to group-level cultural practices and associations, from individual demographic diversity to innate cognitive biases. Drawing on the notion of sociotopography (Palmer, Bill, Jonathon Lum, Jonathan Schlossberg & Alice Gaby. 2017. How does the environment shape spatial language? Evidence for sociotopography.Linguistic Typology21(3). 457–491), the papers in this special collection explore the interaction of factors that shape spatial behavior in language and beyond.
Novel bulking technologies for cellulose fibres
Authors: Lindström Tom , Glad-Nordmark Gunborg 
Published: February 2022

Abstract
This paper deals with the details of preparation of three principal routes for bulking of cellulose fibres. One route is dry cross-linking/hornification using aluminium ions and other salts followed by drying/curing. The mechanisms of these reactions still remain unknown. A second route is physical grafting of fibres using carboxymethylcellulose and bringing the acidic groups into their aluminium form before forming a sheet of paper/board. Hence, curing is not necessary, and this constitutes a unique wet bulking methodology. The mechanism behind this method is believed to be an increase in the surface friction of fibres, when the electrostatic double layer is shielded together with electrostatic cross-linking with aluminium ions. The higher friction between fibres partly prevents the sheet consolidation during drying. A third route is physical grafting of fibres using carboxymethyl cellulose and ion-exchanging the acidic groups with aluminium salts before drying and curing of the fibres. A most interesting factor is that all the thermal treatment methods do not form fibre nodules due to interfibre crosslinking during the heat treatment, a commonly observed phenomena when dealing with chemical crosslinking of fibres. All routes investigated are water-based and should be fairly simple to implement in commercial operations. An inherent advantage is that the bulking is associated with lower water retention values, which should be advantageous for a higher solids content after pressing and, hence, beneficial for paper machine productivity. Bulking is, however, also associated with a loss in bond strength, which in most cases must be alleviated using various additives such as starches and microfibrillated cellulose and it has also been demonstrated in the project how the strength properties (such as z-strength) could be restored at a higher bulk.
Delaware’s copycat: Can delaware corporate law be emulated?
Authors: Baum Ido , Solomon Dov 
Published: February 2022

Abstract
Delaware’s famous corporate law and its highly respected specialized Court of Chancery attract entrepreneurs from all over the world, who choose the small state as their locus of incorporation and litigation forum, and global investors who choose Delaware law as the law governing their corporate investments and mergers and acquisitions (M&A). Other jurisdictions vie with Delaware in regard to these choices. This interjurisdictional competition makes Delaware a significant global norm exporter in the field of corporate law because jurisdictions emulate some of its corporate law. Israel leads the global pack. For two decades, it has been approximating its corporate law to Delaware’s and emulating its principal institutions, including by establishing a specialized Chancery-like court whose judges seek guidance in Delaware’s case law in deciding open corporate law questions.
This Article employs qualitative methods—interviews with M&A practitioners from the United States, the United Kingdom, and Israel. We use the interviews to assess whether the project of approximating Delaware corporate law has succeeded in shifting incorporation decision preferences away from Delaware to Israel and watering down the natural reluctance of global investors to accepting an unfamiliar corporate law when engaging in cross-border corporate M&A transactions involving an Israeli party. Our findings indicate that the approximation project has countervailing effects, opinions about its success being polarized and nuanced; that approximation increases the familiarity of domestic practitioners with the foreign law being emulated, making the emulated law easier to implement; and that approximation creates more room for other aspects of interjurisdictional competition to influence private choices.
Enforcement of foreign judgments, systemic calibration, and the global law market
Authors: Baumgartner Samuel P. , Whytock Christopher A. 
Published: February 2022

Abstract
There are important reasons for states to recognize and enforce the judgments of other states’ courts. There are also reasons that may militate against recognition or enforcement of certain foreign judgments, making it appropriate to calibrate or “fine tune” the presumption favoring recognition and enforcement so it is not applied too broadly. Most calibration principles, such as the principle that a judgment from a court lacking jurisdiction should not be recognized, are case-specific. However, one calibration principle that is, to our knowledge, unique to the law of the United States stands out: the principle of systemic calibration, according to which U.S. courts must not recognize or enforce foreign judgments “rendered under a system which does not provide impartial tribunals or procedures compatible with the requirements of due process of law.” In this Article, we aim to shed empirical light on how U.S.-style systemic calibration operates in practice. We find that state-of-origin indicator scores related to systemic adequacy are on average higher when U.S. courts recognize or enforce foreign judgments than when they refuse to do so. Moreover, the probability of recognition and enforcement increases as these indicator scores increase. However, in only six of the 587 opinions in our dataset did a court refuse recognition or enforcement based explicitly on the systemic inadequacy ground. Thus, while the level of systemic calibration in U.S. courts is high, it is mostly achieved implicitly. Finally, even judgments from states with low systemic adequacy scores are sometimes recognized or enforced by U.S. courts.
Egészségpszichológiai kutatások és az alkalmazott egészségpszichológiai ellátás fejlődése az elmúlt 30 évben Magyarországon
Authors: Kállai János , Urbán Róbert , Csabai Márta 
Published: February 2022

A tanulmány az egészségpszichológia elmúlt évtizedekben Magyarországon lezajlott szakmai fejlődését tekinti át. A programiaddá személyek felsorolása mellett részletesen tárgyalja a kutatási irányokat és az ellátási gyakorlat meghatározó eredményeit. Kiemelt figyelmet fordít a szakma specifikus fogalmainak bemutatására, a beavatkozások kompetenciaterületeire, valamint az egészségpszichológiai, a magatartás-orvoslás, a pszichoszomatika, a klinikai pszichológia területekkel való kapcsolatának értelmezésére. Bemutatja az új szakmai mentalitás és ellátási lehetőségek kialakulását, és ráirányítja a figyelmet az alkalmazott egészségpszichológiai ellátás és az egészségfejlesztés kiemelt fontosságú területeire, a társadalmi és mentális fejlődésben betöltött szerepükre. Továbbá szemelvényeket sorol fel a nemzetközi trendekhez való kapcsolódás kiemelkedő hazai eredményeiről. Az egészségügyi finanszírozást és ellátást tervező országos döntéshozók számára a testi, lelki és szociális egészség növelése érdekében javaslatokat fogalmaz meg az egészségpszichológiai ellátás fejlesztéséhez.The study overviews the development of health psychology in Hungary for the last decades. Besides of the list of the progenitors confers in detail about the research lines and the relevant results of the care and practice. It pays attention to the introduction of the profession-specific concepts and the competence areas of the interventions, furthermore the interpretation of the relationship between health psychology, behavioral medicine, psychosomatic medicine, and clinical psychology. Presents the new mentality and .form of care and highlights the role of the significance of applied psychology and health development in social and mental advancement. Furthermore, specifies a collection from the Hungarian outstanding research data related to relevant international trends. The study contains some proposal for the governmental decision-makers that provides a chance for the health psychological services to develop better bio-psycho-social health in our country.