bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introducing the 3MT_French Dataset to Investigate the Timing of Public Speaking Judgements
Authors: Biancardi Beatrice , Chollet Mathieu , Clavel Chloé 
Published: October 2022

Abstract
In most public speaking datasets, judgements are given after watching the entire performance, or on thin slices randomly selected from the presentations, without focusing on the temporal location of these slices. This does not allow to investigate how people's judgements develop over time during presentations. This contrasts with primacy and recency theories, which suggest that some moments of the speech could be more salient than others and contribute disproportionately to the perception of the speaker's performance.To provide novel insights on this phenomenon, we present the 3MT_French dataset. It contains a set of public speaking annotations collected on a crowd-sourcing platform through a novel annotation scheme and protocol. Global evaluation, persuasiveness, perceived self-confidence of the speaker and audience engagement were annotated on different time windows (i.e., the beginning, middle or end of the presentation, or the full video). This new resource will be useful to researchers working on public speaking assessment and training. It will allow to fine-tune the analysis of presentations under a novel perspective relying on socio-cognitive theories rarely studied before in this context, such as first impressions and primacy and recency theories. An exploratory correlation analysis on the annotations provided in the dataset suggests that the early moments of a presentation have a stronger impact on the judgements.
Lithium carbonate in Amyotrophic Lateral Sclerosis patients homozygous for the C-allele at SNP rs12608932 in UNC13A; protocol for a confirmatory, randomized, group-sequential, event-driven, double-blind, placebo-controlled trial.
Authors: Willemse Sean William , Roes Kit CB , Damme Philip Van , Hardiman Orla , Ingre Caroline , Povedano Monica , Wray Naomi R , Gijzen Marleen , de Pagter Mirjam S , Demaegd Koen C , Janse Annemarie FC , Vink Roel C , Sleutjes Boudewijn THM , Chiò Adriano , Corcia Philippe , Reviers Evy , Al-Chalabi Ammar , Kiernan Matthew C , Berg Leonard H van den , Es Michael A van , Eijk Ruben PA van 
Published: October 2022

Abstract
Background

Given the large genetic heterogeneity in Amyotrophic Lateral Sclerosis (ALS), it seems likely that genetic subgroups may benefit differently from treatment. An exploratory meta-analysis identified that patients homozygous for the C-allele at SNP rs12608932, a single nucleotide polymorphism in the gene UNC13A, had a statistically significant survival benefit when treated with lithium carbonate. We aim to confirm the efficacy of lithium carbonate on the time to death or respiratory insufficiency in patients with ALS homozygous for the C-allele at SNP rs12608932 in UNC13A.

Methods

A randomised, group-sequential, event-driven, double-blind, placebo-controlled trial will be conducted in 15 sites across Europe and Australia. Patients will be genotyped for UNC13A; those homozygous for the C-allele at SNP rs12608932 will be eligible. Patients must have a diagnosis of ALS according to the revised El Escorial criteria, and a TRICALS risk-profile score between − 6.0 and − 2.0. An expected number of 1,200 patients will be screened in order to enrol a target sample size of 171 patients. Patients will be randomly allocated in a 2:1 ratio to lithium carbonate or matching placebo, and treated for a maximum duration of 24 months. The primary endpoint is the time to death or respiratory insufficiency, whichever occurs first. Key secondary endpoints include functional decline, respiratory function, quality of life, tolerability, and safety. An interim analysis for futility and efficacy will be conducted after the occurrence of 41 events.

Discussion

Lithium carbonate has been proven to be safe and well-tolerated in patients with ALS. Given the favorable safety profile, the potential benefits are considered to outweigh the burden and risks associated with study participation. This study may provide conclusive evidence about the life-prolonging potential of lithium carbonate in a genetic ALS subgroup.

Trial registration

EudraCT number 2020-000579-19, registered on 29-03-2021. https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-000579-19/NL
Pattern of strong earthquakes
Authors: Mizrahi Ezra , Shapira Avi , Mizrahi Moran , Terem Omri , Hofstetter Rami 
Published: October 2022

Abstract
The idea that one earthquake is associated with the occurrence of another earthquake is not new. In this study, we focus our attention on the relationships between the occurrence of a relatively strong earthquake in a certain seismogenic region and the occurrence of an earthquake of similar magnitude in a distant region. The complete catalog of seismic activity between 1904–2016 documents the subsequent events and over the years reveals a global, seismic activity pattern, (GSAP). This pattern is evident when an earthquake of magnitude M is followed within a relatively short period of weeks by an earthquake of a similar magnitude, and where the two events are located on latitudes of practically the same absolute value. Roughly 90% of all earthquakes of magnitude 6.5 and above follow the GSAP within a time window of less than a year. In addition, this high GSAP rate remains constant even after shuffling the dates of the earthquakes, several times. This is also evident in the current model of the tectonic plates and the frequency-magnitude relationships associated with each seismogenic zone. Subsequently, the observed seismic activity pattern is probably a statistical product and does not appear to relate to a physical causative process. At the same time, the significance of the GSAP, leads us to consider that the GSAP can be harnessed for statistical earthquake forecasting. This idea was, grounded and evaluated using synthetic earthquake catalogues where the success rates of forecasting an earthquake in catalog B followed the occurrence of an earthquake in catalog A. Additionally, the success rate of forecasting events in catalog B, according to the GSAP definitions are demonstrated to be statistically lower than the probabilities of a random occurrence in a similar magnitude earthquake which appears in ISC catalog B. These results were compared to actual cases. Arbitrarily selected pairs of seismogenic zones that are located on the same latitudes clearly demonstrate that the success rate of forecasting the earthquake occurrences that adhere to the GSAP are always higher than mere guesswork and therefor may be considered to offer a potential operational earthquake forecasting tool.
QuickDiag: A low cost oral cancer detection kit
Authors: Bhirud Ritesh , Rane Nileema 
Published: October 2022

Abstract
Significance: Oral cancer is a cancerous growth in the oral cavity. More than 90% of all oral cancers are squamous cell carcinoma. Oral squamous cell carcinoma has the highest mortality ratio compared to other carcinomas. The high mortality rate is mainly due to detection of the cancer in an advanced stage on account of its initial asymptomatic nature. In addition, the methods currently in place for oral cancer detection involve expensive complex laboratory procedures and usually longer wait times for patients leading to late diagnosis. Further, the treatments for advanced staged cancers are costly and less effective in terms of the posttreatment survival rates. Thus, society needs an easy-to-use tool for assessing oral cancers at an early stage.
Aim: The aim of the project is to develop an easily accessible multi-step point of-care kit which will assist in early detection of oral cancer at a low cost in vulnerable population.
Approach: The kit developed consisted of a complete and easy to operate home-based test. The test was based on the patient’s salivary and photo sample to obtain an oral cancer risk-analysis with detailed statistics on a custom developed app. These results were based on a thermal reaction of a formulated Thiobarbituric Acid reagent along with a spectroscopy sensor connected to a smartphone to determine oral cancer risk based on malondialdehyde (MDA) concentration, which is a product of the free radicals generated by smoking (leading cause of oral cancer).
For the image screening, a simple yet effective centered rule image-capturing approach was proposed for collecting oral cavity images. Then, based on this method, a medium-sized oral dataset with five categories of diseases was created, and a resampling method was presented to alleviate the effect of image variability from hand-held smartphone cameras. Finally, a recent deep learning network (HRNet) was introduced to evaluate the performance of our method for oral cancer detection.
Results: The image screening method achieved a sensitivity of 78.0%, specificity of 91%, and precision of 80% on 400 test images. In addition, the chemical test detected salivary MDA levels with 94% accuracy among 400 samples.
Theoretical mass spectrum of Helicobacter pylori
Authors: Ng Wenfa 
Published: October 2022

Abstract
RNA-seq transcriptomics has revolutionized the way we understand gene expression, by providing us granular view of the expression level of individual genes across the genome. Typically, an RNA-seq transcriptome is dissected in different ways from different perspectives yielding multi-facet views of the cellular processes of the organism. This work attempts to relook how to visualise the top 20 high expression level proteins of an RNA-seq transcriptome as a theoretical mass spectrum of the species. In this conceptualisation, the expression count of the protein will be the proxy for relative mass count intensity, while the molecular weight of the proteins will be the x-axis of the theoretical mass spectrum. Such a mass spectrum can be interpreted in many ways with conclusions having deep roots in experiment as the original RNA-seq data is obtained with experiments. One use of the theoretical mass spectrum would be to inform us of the postulated growth rate of the species under given conditions through the average count of the profiled mass peaks. High count signifies high protein synthesis, and thus, growth rate. In another use, the theoretical mass spectrum could provide indicative evidence of the type of proteins that define, modulate or govern the physiological process of the cells. Although coarse in understanding, getting an answer of whether high or low molecular weight proteins define the physiological processes of the cells may have unexpected implications that is not apparent with today’s technology and knowledge base in biology. This work introduces the theoretical mass spectrum of Helicobacter pylori, an important human stomach pathogen that is the causative agent of stomach cancer.
Detection of Rockfalls on Tunnel Faces Using Extracted Moving Objects, Excavation Point Estimation, and Generation of Trajectory Images
Authors: Kobayashi Rei , Sato Yoshihiro , Takahashi Yoshiki , Maemura Masahito , Miura Masaya , Bao Yue 
Published: October 2022

Background:
Tunnels are constructed at various locations for infrastructural purposes. During tunnel construction, industrial accidents have occurred due to rockfalls at tunnel faces. In addition, it has been confirmed that large rockfalls are precursors to tunnel collapses. Visual monitoring is currently used to detect such rockfalls. However, there are limitations to visual monitoring, and monitoring equipment is needed.

Objective:
In existing research, the inter-frame difference method of image processing and laser measurement methods have been proposed. However, there are difficulties in monitoring the entirety of the tunnel face using these methods. Thus, we propose methods that can overcome these difficulties and accurately detect rockfalls and identify where they occur.

Methods:
In this study, we propose a method for detecting rockfalls by combining the extraction of moving objects on a tunnel face and the estimation of excavation points. To identify the location of the rockfalls, rockfall trajectory images were generated.

Results:
Through experiments conducted during excavation, it was confirmed that the proposed method could correctly identify and detect only rockfalls in real time and identify the locations where they occurred.

Conclusion:
In this study, only rockfalls of 52 mm x 71 mm in size are detected in real time. It can enable workers to evacuate and prevent industrial accidents. In addition, by identifying the location of rockfalls, it is possible to know the danger level of the tunnel face.
Gender Differences in Twitter Complaints
Authors: Abdul Kadir Zaemah , Mohd Ali Norsyafigah , Syed Husain Sharifah Shahnaz , Zubir Zurina 
Published: October 2022

This study aimed to identify and compare the different strategies used by males and females in making complaints. Both genders adopt different strategies when making complaints. In this qualitative study, the content analysis method was adopted, and based on Trosborg's Theory of Complaint, complaints messages posted by 23 Twitter users were analyzed. The results showed that males perform dissatisfaction more frequently than females. However, females use blame strategy at a higher frequency than males. This research revealed a new perspective on gender differences and valuable insights influencing complaint-making strategies.
Keywords: Complaints, Code-switching, Language Choice, Strategies
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7iSI7%20(Special%20Issue).3763
Empirical Identification of Perceptual Design Criteria for Ablution Concept
Authors: Mohamed Raif Diana , Anwar Rusmadiah , Baharom Mohd Khairi 
Published: October 2022

This paper was initiated based on the conceptual framework of Ablution Function Mean Analysis relating to a phenomenon that impacts designer perception in developing new product development for religious-based design. Empirical observation of user-designer exploring the convergent process of ablution design development was set up. The ablution performed, the perceptions verbalized, and the different design principles targeted were analyzed from a qualitative and a quantitative point of view. This study's data were first measured to obtain an appreciation of Muslims performing ablution behaviour. The study focused on the product gestalt, recognising the design act of divergent and convergent transpires in a real context, and identifying the spontaneous control reflection that influences the resulting product perception.
Keywords: Design gestalt; ablution; design thinking.
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7iSI7%20(Special%20Issue).3783
FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases (FAST-01): Protocol for the First Prospective Feasibility Study
Authors: Daugherty Emily C , Mascia Anthony , Zhang Yong , Lee Eunsin , Xiao Zhiyan , Sertorio Mathieu , Woo Jennifer , McCann Claire , Russell Kenneth , Levine Lisa , Sharma Ricky , Khuntia Deepak , Bradley Jeffrey , Simone II Charles B , Perentesis John , Breneman John 
Published: October 2022

Background
In preclinical studies, FLASH therapy, in which radiation delivered at ultrahigh dose rates of ≥40 Gy per second, has been shown to cause less injury to normal tissues than radiotherapy delivered at conventional dose rates. This paper describes the protocol for the first-in-human clinical investigation of proton FLASH therapy.

Objective
FAST-01 is a prospective, single-center trial designed to assess the workflow feasibility, toxicity, and efficacy of FLASH therapy for the treatment of painful bone metastases in the extremities.

Methods
Following informed consent, 10 subjects aged ≥18 years with up to 3 painful bone metastases in the extremities (excluding the feet, hands, and wrists) will be enrolled. A treatment field selected from a predefined library of plans with fixed field sizes (from 7.5 cm × 7.5 cm up to 7.5 cm × 20 cm) will be used for treatment. Subjects will receive 8 Gy of radiation in a single fraction—a well-established palliative regimen evaluated in prior investigations using conventional dose rate photon radiotherapy. A FLASH-enabled Varian ProBeam proton therapy unit will be used to deliver treatment to the target volume at a dose rate of ≥40 Gy per second, using the plateau (transmission) portion of the proton beam. After treatment, subjects will be assessed for pain response as well as any adverse effects of FLASH radiation. The primary end points include assessing the workflow feasibility and toxicity of FLASH treatment. The secondary end point is pain response at the treated site(s), as measured by patient-reported pain scores, the use of pain medication, and any flare in bone pain after treatment. The results will be compared to those reported historically for conventional dose rate photon radiotherapy, using the same radiation dose and fractionation.

Results
FAST-01 opened to enrollment on November 3, 2020. Initial results are expected to be published in 2022.

Conclusions
The results of this investigation will contribute to further developing and optimizing the FLASH-enabled ProBeam proton therapy system workflow. The pain response and toxicity data acquired in our study will provide a greater understanding of FLASH treatment effects on tumor responses and normal tissue toxicities, and they will inform future FLASH trial designs.

Trial Registration
: ClinicalTrials.gov NCT04592887; http://clinicaltrials.gov/ct2/show/NCT04592887

International Registered Report Identifier (IRRID)
DERR1-10.2196/41812
Leveraging Mobile Health to Manage Mental Health/Behavioral Health Disorders: Systematic Literature Review
Authors: Kruse Clemens Scott , Betancourt Jose  A , Gonzales Matthew , Dickerson Kennedy , Neer Miah 
Published: October 2022

Background
Mental health is a complex condition, highly related to emotion. The COVID-19 pandemic caused a significant spike in depression (from isolation) and anxiety (event related). Mobile Health (mHealth) and telemedicine offer solutions to augment patient care, provide education, improve symptoms of depression, and assuage fears and anxiety.

Objective
This review aims to assess the effectiveness of mHealth to provide mental health care by analyzing articles published in the last year in peer-reviewed, academic journals using strong methodology (randomized controlled trial).

Methods
We queried 4 databases (PubMed, CINAHL [Cumulative Index to Nursing and Allied Health Literature], Web of Science, and ScienceDirect) using a standard Boolean search string. We conducted this systematic literature review in accordance with the Kruse protocol and reported it in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) 2020 checklist (n=33).

Results
A total of 4 interventions (mostly mHealth) from 14 countries identified improvements in primary outcomes of depression and anxiety as well as in several secondary outcomes, namely, quality of life, mental well-being, cognitive flexibility, distress, sleep, self-efficacy, anger, decision conflict, decision regret, digestive disturbance, pain, and medication adherence.

Conclusions
mHealth interventions can provide education, treatment augmentation, and serve as the primary modality in mental health care. The mHealth modality should be carefully considered when evaluating modes of care.

Trial Registration
PROSPERO International Prospective Register of Systematic Reviews CRD42022343489; https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=343489
Estrategias didácticas con TIC en la formación del profesorado de Educación Primaria
Authors: Navarro-Montaño María José , Piñero-Virué Rocío , Jiménez Navarro Paula , Mateo Navarro Victor 
Published: October 2022

El estudio se fundamenta en la necesidad de promover metodologías colaborativas en la formación del profesorado, implicando al estudiante en la construcción de su propio proceso formativo, mediante el uso de estrategias educativas inclusivas. El objetivo principal es “Desarrollar metodologías participativas en la formación docente, basadas en estrategias didácticas inclusivas y los principios del Diseño Universal para el Aprendizaje, DUA”. La metodología utilizada es cualitativa. La recogida de datos se realiza mediante la creación de 20 Grupos de Discusión en los que se genera diálogo a partir de los interrogantes planteados. Las conclusiones y su discusión se presentan con base en los objetivos del estudio y revelan que las metodologías activas y participativas se desarrollan mediante estrategias didácticas, siendo el manejo de habilidades y destrezas desigual, ya que su uso difiere según la estrategia.
Estrategias de Aprendizaje en inglés empleadas por estudiantes universitarios de Pedagogía de una universidad mexicana
Authors: Guerrero Rodríguez Lilia Esther , Pérez Vences Mayté , Dajer Torres Regina , Villalobos López Marilú , Méndez Jiménez Yesika 
Published: October 2022

El aprendizaje del inglés como segunda lengua es fundamental en la formación universitaria. La presente investigación tuvo como objetivo analizar las estrategias de aprendizaje que emplean los alumnos de la Facultad de Pedagogía de una universidad en México para el desarrollo de competencias en el idioma inglés. Para lograr ese objetivo, se acudió al paradigma cualitativo y el método fenomenológico, a través de la aplicación de entrevistas a un grupo de 15 estudiantes de la Facultad de Pedagogía, siguiendo un protocolo de entrevistas semiestructurado. Se establecieron tres categorías deductivas a priori para orientar las entrevistas: Conocimientos previos, Afinidad para estudiar el idioma e Información e incorporación de estrategias de aprendizaje. Los discursos fueron analizados mediante el procedimiento de análisis categorial, lo cual permitió identificar subcategorías emergentes. Los resultados muestran que los estudiantes no aplican conscientemente estrategias de aprendizaje (cognitivas, metacognitivas y/o socioafectivas) y tampoco aprovechan el entorno didáctico existente para desarrollar un proceso de aprendizaje autónomo del inglés.
Educar socioafectivamente en tiempos de pandemia: una mirada desde la neuroeducación
Authors: Valdes Belén , Lazzaro-Salazar Mariana 
Published: October 2022

El presente artículo analiza el contexto educativo actual de pandemia provocado por el COVID-19 y orienta su desarrollo en vista de una reformulación desde la perspectiva de la neuroeducación, e invita a la transformación de la pedagogía y la forma en la cual los estudiantes reciben la educación, tomando como punto de partida para la discusión la realidad de la educación básica en Chile. En este contexto, el presente estudio tiene como objetivo revisar y analizar los aportes teóricos que los principios de la neuroeducación entregan a la práctica docente y adaptarlos al contexto de pandemia, centrando el interés en la importancia de la educación socioafectiva en tiempos de crisis. El encuadre metodológico se orienta desde la revisión literaria y teórica de la neuroeducación. Para finalizar, se presentan estrategias adaptadas desde la literatura para abordar y potenciar las habilidades de aprendizaje en la educación virtual desde una mirada socioafectiva.