bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manipulations of oblique pulling affect sacroiliac joint displacements and ligament strains: a finite element analysis
Authors: Xu Zhun , Feng Ziyu , Zhang Zhaocong , Liao Liqing , Liu Dan , Zhang Kunmu , Yan Yiguo , Li Yikai 
Published: June 2022

Abstract
Background
Clinical studies have found that Manipulation of oblique pulling (MOP) has a good clinical effect on sacroiliac joint (SIJ) pain without specific causes. However, there is no uniform standard for MOP at present. The effects of MOPs with different force points and directions on SIJs are not clear. The purpose of this study was to investigate the effects of four MOPs on the stresses and displacements of the normal SIJ and the strains of the surrounding ligaments.
Methods
A three-dimensional finite element model of the pelvis was established. Four MOPs were simulated. The stresses and displacements of the SIJ and the strains of the surrounding ligaments were analyzed under four MOPs.
Results
MOP-F2 caused the highest stress on the pelvis, at 85.0 MPa, while MOP-F3 caused the lowest stress on the pelvis, at 52.6 MPa. MOP-F3 produced the highest stress on the left SIJ, at 6.6 MPa, while MOP-F1 produced the lowest stress on the left SIJ, at 5.6 MPa. The four MOPs mainly produced anterior-posterior displacement of SIJ. The maximum value was 1.21 mm, produced by MOP-F2, while the minimal value was 0.96 mm, produced by MOP-F3. The four MOPs could all cause different degrees of ligament strain around the SIJ, and MOP-F2 produced the greatest ligament strain.
Conclusions
The four MOPs all produced small displacements of the SIJ and different degrees of ligament strain. MOP-F2 produced the largest displacement of SIJ and the greatest ligament strain, which could provide a certain reference for physiotherapists.
Short-term effects of extreme meteorological factors on daily outpatient visits for anxiety in Suzhou, Anhui Province, China: A time series study
Authors: Zhang Xiaowei , Ji Yanhu , Yang Zidan , Luo Yandong , Li Liping 
Published: June 2022

Abstract
Anxiety disorders are a major public health concern in China. Previous studies have provided evidence for associations between ambient temperature and anxiety outpatient visits, but no studies have examined short-term effects of other meteorological factors such as sunshine duration, wind speed and precipitation on increased anxiety outpatient visits. We aimed to assess the association between climatic factors and outpatient visits for anxiety in Suzhou, a city with a temperate climate in Anhui Province, China. Daily anxiety outpatient visits, meteorological factors, and air pollutants from 2017 to 2019 were collected. A quasi-Poisson generalized linear regression model combined with distributed lag non-linear model (DLNM) was used to quantify the effects of extreme meteorological factors (sunshine duration, wind speed and precipitation) on anxiety outpatient visits. All effects were presented as relative risk (RR), with the 90th and 10th percentiles of meteorological factors compared to the median. Subgroup analyses by age and gender were performed to identify susceptible subgroups. A total of 11 323 anxiety outpatient visits were reported. Extremely low sunshine duration, low and high speed speed increased the risk of anxiety outpatient visits. The strongest cumulative effects occurred at lag 0–14 days, and the corresponding RRs of extremely low sunshine duration, low and high wind speed were 1.417 (95% CI: 1.056–1.901), 1.529 (95% CI: 1.028–2.275) and 1.396 (95% CI: 1.007–1.935), respectively. Subgroup analyses showed that males and people aged ≥ 45 years appeared to be more susceptible to the cumulative effects of extremely low sunshine duration. In addition, the adverse effects of extreme wind speed were more pronounced in the cold season. This study provides evidence that extreme climatic factors have a lagged effect on anxious outpatient visits. In the context of climate change, these findings may help develop weather-based early warning systems to minimize the effects of extreme meteorological factors on anxiety.
No evidence for an association between alcohol consumption and Multiple Sclerosis risk
Authors: Dreyer-Alster Sapir , Achiron Anat , Giovannoni Gavin , Jacobs Benjamin , Dobson Ruth 
Published: June 2022

Abstract
Multiple Sclerosis (MS) is an autoimmune disorder of the central nervous system characterised by episodes of inflammatory demyelination superimposed on gradual neuroaxonal loss. It is a prototypic complex disease in that there is both a heritable component and an environmental component to susceptibility. A protective link between alcohol consumption and MS risk has been demonstrated in Swedish and Danish cohorts, but evidence from other cohorts and mendelian randomisation studies have failed to support such a relationship. We assessed the relationship between alcohol consumption and MS in UK Biobank (UKB), a longitudinal cohort study of ~500,000 adults living in the UK. Despite reasonably statistical power, we found no evidence for an association between alcohol consumption and MS risk, nor did we find evidence of an interaction between non-drinking and HLA-DRB1*15:01.
The Contagious Leader: A Panel Study on Occupational Stress Transfer in a Large Danish Municipality
Authors: Bonnesen Lærke , Pihl-Thingvad Signe , Winter Vera 
Published: June 2022

Abstract
Occupational stress has immense economic and health-related consequences for individuals, organizations, and societies. In this context, the question of whether and how stress among managers transmits to their subordinates is highly interesting, yet not profoundly researched. This study aims to empirically investigate the effect of manager occupational stress on the development of subordinate stress and for how long such effects last in time. We exploit a unique panel dataset based on three different surveys among employees from a large Danish municipality, covering 5,653 employees and their 452 immediate managers between 2016 and 2020. We analyze this data using a fixed effects estimator with clustered robust standard errors, allowing us to significantly reduce potential endogeneity issues. The study shows that managers do in fact ‘transmit’ stress onto their employees, that the relationship is detectable a full year after the initial transmission of stress occurred, and that such an effect fades within additional two years. Our study serves to emphasize the great importance of the psychosocial wellbeing of managers as ‘nerve centers’ for entire job teams and urges organizations to treat stress among personnel on management levels with a high degree of concern.
Perianal Complications in Puerperium and Associated Risk Factors
Authors: Iyer Sriranjani , Jadhav Sarojini P. , Kandi Anita , Soyam Suraj 
Published: June 2022

Abstract
INTRODUCTIONPuerperium is defined as the period of about six weeks after childbirth during which the mother's reproductive organs return to their original non-pregnant condition. Perianal problems, including Constipation, Hemorrhoids and Fissure, are among the most common digestive complications among women in puerperium, observed in about 30 to 50 percent of women. Considering this great prevalence and the paucity of similar research in this aspect in an Indian population, this study was done to assess the prevalence of perianal problems seen in puerperium and the risk factors associated with it.METHODSThis was a prospective observational cohort study done over the span of 3 years on 902 puerperal ladies. A self structured questionnaire covered detailed history and per-rectal and proctoscopy examination. Patients were followed up telephonically for regression of perianal problems post management. RESULTSThe Total prevalence of all the perianal problems in puerperium encountered in this study, out of 902 subjects, was 36.3% [327 subjects]. The Perianal problems encountered were Fissure in 185 patients [20.5%] followed by Haemorrhoids in 110 patients [12.2%], Perianal episiotomy infections in 25 patients [2.8%] and Perineal tears in 7 patients [0.8%]. On comparative analysis, Positive family history, macrosomia, past history of perianal diseases, second stage of labour >50 minutes showed a higher prevalence in Perianal disease Group as compared to the Healthy group. Out of these, Positive family history of perianal diseases [p=0.015], past history of perianal diseases [p=0.016] were statistically significant. The percentage of multipara with Hemorrhoids was more as compared to primipara [p=0.01], patients who had a past history of any perianal disease have higher chance of Hemorrhoids during puerperium [p=0.00]. Patient with constipation in pregnancy have higher chance of hemorroids in pregnancy [p=0.00]. Patients who had a past history of any perianal disease, had higher chance of fissure during puerperium [p=0.00]. 27.74% of study subjects with macrosomic babies had fissure in their puerperal period which on comparison with patients with non macrosomic babies was only 19.22% and this was statisticallty significant [p=0.02]. CONCLUSIONConstipation, haemorrhoids, anal fissures are the most common perianal problems in postpartum period causing significant reduction in life quality of those afflicted with them.
Molecular characterisation of a novel pathogenic avipoxvirus from an Australian little crow (Corvus bennetti) directly from the clinical sample
Authors: Sarker Subir , Sutherland Michelle 
Published: June 2022

Abstract
Avipoxviruses are thought to be restricted to avian hosts and considered significant pathogens that may impact the conservation of many birds. However, reports of avipoxvirus-like viruses from reptiles suggest that cross-species transmission, within birds and other species, may be possible. The vast majority of avipoxviruses in wild birds remain uncharacterised and their genetic variability is unclear. Here, cutaneous pox lesions were used to recover a novel full-length crowpox virus (CRPV) genome from an Australian little crow (Corvus bennetti), followed by the detection of immature and intracellular mature virions using electron microscopy. The CRPV genome was 328,768 bp in length and contained 403 predicted open-reading frames (ORFs). While 356 of the ORFs of CRPV genome had the greatest similarity with other avipoxviruses gene products, a further 47 ORFs were novel. Subsequent phylogenetic analyses showed that the CRPV was most closely related to other avipoxviruses isolated from passerine and marine bird species and demonstrated the highest sequence similarity with an albatrosspox virus (84.4%). Considering the sequence similarity observed between CRPV and other avipoxviruses and phylogenetic position, this study concluded that the CRPV to be the distinct available candidate of avipoxviruses.
Investigation of PSO algorithms for optimizing dual-Fano-resonance sensor
Authors: Li Chengying , HUANG TIANYE , NI XIAOYONG , Dang Xueyan , Han Lei 
Published: June 2022

Abstract
Objectives
The optimization of the dual-parameter Fano resonance (FR) sensor based on the surface plasmon resonance (SPR) relies on the conventional parametric sweep method, which is time-consuming and difficult to find the optimized design. This paper aims to investigate the approaches for finding the best design automatically.
Methods
A particle swarm optimization (PSO) algorithm combining the linear weighted sum method (LWSM) and the technique for order preference by similarity to an ideal solution (TOPSIS) are proposed to optimize the structure parameters efficiently. Then the multi-objective particle swarm optimization (MOPSO) algorithm is used to compare the optimization results with the proposed algorithm.
Results
After several optimization iterations, the PSO-LWSM and PSO-TOPSIS optimize the sensitivity to 795 nm/RIU and 0.024 nm/°C with 30 iterations, and the MOPSO algorithm optimizes the sensitivity to 790 nm/RIU and 0.023 nm/°C with 100 iterations. The structures obtained through these two methods are similar and give the results within a shorter time than the parametric sweep method. The MOPSO algorithm can find more combinations of optimized solutions than the PSO-LWSM and PSO-TOPSIS, but it takes more time.
Conclusion
In summary, the proposed algorithms are better and faster optimization approaches than the traditional parametric scanning method for optimizing FR-based sensors.
Development of a Novel SARS-CoV-2 Immune Complex Vaccine Candidate (CRCx) with Broad Immune Responses: A Preclinical Trial in Animal Model.
Authors: Zayed Khalid , Abdulaziz Sherif , Mubaraki Abdullah , Abdallah Khaled 
Published: June 2022

Abstract
Background: The ongoing pandemic of COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a serious threat to global public health and imposes a severe burden on the entire human population. Faced with a virus that can mutate its structure while immunity is incapacitated, a need to develop a universal vaccine that can boost immunity to coronaviruses is highly needed.Design: Five formulations of two types (CRCx2 and CRCx3) of immune complexes with an immunogen adjuvant were evaluated in a mouse model as candidate SARS CoV-2 vaccines in a pretrial prior to clinical trials in humans. CRCx3 comprises 3 different formulas and CRCx2 comprises 2. Balb/c mice were vaccinated intraperitoneally on days 0/7 with a high or low dose of CRCx2 or on days 0/7/14 with a high, medium, or low dose of CRCx3 series, and their blood was sampled for serum antibody measurements. Mice were challenged with live virus after immunization with either vaccine to evaluate prophylaxis ability or treated with them after challenge to evaluate therapeutic ability on day 15. Immunological markers and histopathological studies as well as titration of neutralizing antibodies to the vaccines were evaluated and analyzed.Results: CRCx 3 and CRCx 2 vaccine candidates induced elevated levels of positive neutralizing antibodies as well as a cellular immune response with safety, efficient productivity, and good genetic stability for vaccine manufacturing to provide protection against SARS-CoV-2 with relatively higher levels with the high dose CRCx2 candidate combination.Conclusions: Highly efficient protection and therapeutic effect against SARS-CoV-2 were obtained with a double-dose immunization schedule spaced at 7-day intervals using injections of 0.25 or 0.40 ml of CRCx2 vaccine formulations with a 25-mm needle. These results support further evaluation of CRCx in a clinical trial on humans.
Azide-functionalized Ligand Enabling Organic–Inorganic Hybrid Dielectric for High-Performance Solution-Processed Oxide Transistors
Authors: Lee Juhyeok , Hassan Syed Zahid , Lee Sangjun , Sim Hye Ryun , Chung Dae Sung 
Published: June 2022

Abstract
We propose a highly efficient crosslinking strategy for organic–inorganic hybrid dielectric layers using newly synthesized azide-functionalized acetyl acetonate, which covalently connect inorganic particles (ZrO2 NP) to polymers (PMMA), enabling highly efficient inter- and intra-crosslinking of organic and inorganic inclusions, resulting in a dense and defect-free thin-film morphology. From the optimized processing conditions, we obtained an excellent dielectric strength of over 4.0 MV/cm, a high dielectric constant of ~ 14, and a low surface energy of 38 mN/m. We demonstrated the fabrication of exceptionally high-performance, hysteresis-free n-type solution-processed oxide transistors comprising an In2O3/ZnO double layer as an active channel with an electron mobility of over 50 cm2V− 1s− 1, on/off ratio of ~ 107, subthreshold swing of 108 mV dec-1, and outstanding bias stability. From temperature-dependent I–V analyses combined with charge transport mechanism analyses, we demonstrated that the proposed hybrid dielectric layer provides percolation-limited charge transport for the In2O3/ZnO double layer under field-effect conditions.
Effects of diversity on thermal niche variation in bird communities under climate change
Authors: Marjakangas Emma-Liina , Santangeli Andrea , Johnston Alison , Michel Nicole L. , Princé Karine , Lehikoinen Aleksi 
Published: June 2022

Abstract
Climate change alters ecological communities through effects on individual species and interactions between species. The impacts of climate change may be buffered by community diversity: diverse communities may be more resistant to climate-driven perturbations than simple communities. Here, we assess how diversity influences long-term thermal niche variation in communities under climate change. We use 50-year continental-scale data on bird communities during breeding and non-breeding seasons to quantify the communities’ thermal variability. Thermal variability is measured as the temporal change in community’s average temperature niche that indicates its response to climate change. Then, we study how the thermal variability varies as a function of taxonomic, functional, and evolutionary diversity using linear models. We find that communities with low thermal niche variation have higher functional diversity, with this pattern being measurable in the non-breeding but not in the breeding season. Given the increasing seasonal variation in the future climate change effects, the differences in bird communities’ thermal variability between breeding and non-breeding seasons may grow wider. Importantly, our results suggest that functionally diverse wildlife communities can mitigate negative effects of climate change by means of hindering changes in thermal niche variability, underscoring the importance of addressing the climate and biodiversity crises together.
Novel approach to push the limit of temporal resolution in ultrafast electron diffraction accelerators
Authors: Esuain Benat Alberdi , Hwang Ji-Gwang , Neumann Axel , Kamps Thorsten 
Published: June 2022

Abstract
Ultrafast electron diffraction techniques that employ relativistic electrons as a probe have been in the spotlight as a key technology for visualizing structural dynamics which take place on a time scale of a few femtoseconds to hundreds femtoseconds. These applications highly demand not only extreme beam quality in 6-D phase space such as a few nanometer transverse emittances and femtosecond duration but also equivalent beam stability. Although these utmost requirements have been demonstrated by a compact setup with a high-gradient electron gun with state-of-the-art laser technologies, this approach is fundamentally restricted by its nature for compressing the electrons in a short distance by a ballistic bunching method. Here, we propose a new methodology that pushes the limit of timing jitter beyond the state-of-the-art by utilizing consecutive RF cavities. This layout already exists in reality for energy recovery linear accelerator demonstrators. Furthermore, the demonstrators are able to provide MHz repetition rates, which are out of reach for most conventional high-gradient electron guns.
Preparation of peanut shell cellulose nanofibrils and their superhydrophobic aerogels and their application on cotton fabrics
Authors: Chen Kouqin , Wang Liming , Xu Lihui , Pan Hong , Hao Huimin , Guo Fangying 
Published: June 2022

Abstract
Nowadays, the application range of biomass materials was more and more extensive.In this work,peanut shell powder was used as the raw material. The nanocellulose is extracted from it by chemical mechanical method.Then, using the sol-gel method, methyltrimethoxysilane(MTMS) is added to the peanut shell nanocellulose suspension to modify it. Finally, the nano-cellulose superhydrophobic aerogel was prepared by freeze-drying method. The nano-cellulose aerogel and polydimethylsiloxane (PDMS) were finished on the cotton fabric by spraying method, and the superhydrophobic aerogel and superhydrophobic cotton fabric were analyzed and characterized respectively. The results show that the prepared nanocellulose aerogel has a three-dimensional sheet-like structure with superhydrophobicity. The hydrophobic properties and water contact angle (WCA) of cotton fabrics were significantly improved after superhydrophobic finishing. The WCA can reach 160.4°, the finished fabric has good antifouling performance and self-cleaning performance, and the oil-water separation efficiency reaches 82.2%.
Heat transfer in aluminum-steel joint and weld tool during the friction stir welding: Simulation and experimental validation
Authors: Ou Wenmin , Guo Guolin , Cui Chenshuo , Zhang Yaocheng , Qian Longgen 
Published: June 2022

Abstract
The heat transfer behaviors are important to control the performance of Aluminum-Steel joint. However, because the models with weld tool are majorly tested for the same material joints, the heat transfer behaviors with weld tool for aluminum-steel joint are not fully understood. In this paper, a novel CFD model with weld tool is developed and tested to investigate the effects of weld tool on the aluminum-steel joint. The calculated temperature and thermal cycles for various traverse speed agreed well with the corresponding IR experimental results. It is found that the model with weld tool can decrease the temperature gradient and inhomogeneity of temperature field for aluminum-steel joint. The model with weld tool can provide calculated viscosity based on the validated temperature field to analysis the insufficient stirring defect of aluminum-steel joint.
Generation of a novel recombinant antibody for sensitive detection of Pseudomonas aeruginosa
Authors: Lim Gyu-Min , Kim Joo-Kyung , Kim Eun-Jung , Lee Chang-Soo , Kim Wooseong , Kim Byung-Gee , Jeong Hee-Jin 
Published: June 2022

Abstract
Pseudomonas aeruginosa (P. aeruginosa) is a major pathogen that causes nosocomial infections and often exhibits antibiotic resistance. Therefore, the development of an accurate method for detecting P. aeruginosa is required to control P. aeruginosa-related outbreaks. In this study, we established an enzyme-linked immunosorbent assay (ELISA) method for the sensitive detection of three P. aeruginosa strains, UCBPP PA14, ATCC 27853, and multidrug-resistant ATCC BAA-2108. We produced a recombinant antibody (rAb) against P. aeruginosa using mammalian cells with high yield and purity, and confirmed its P. aeruginosa binding efficiency. The rAb was paired with commercial anti-P. aeruginosa Ab for a sandwich ELISA, resulting in an antigen-concentration- dependent response with a limit of detection value of 23 CFU. These results suggest that the rAb produced herein can be used for the sensitive detection of P. aeruginosa with a wide range of applications in clinical diagnosis and point-of-care testing.
Co-simulation based Digital Twin for Thermal Characteristics of Motorized Spindle
Authors: Yi Haoran , Fan Kaiguo 
Published: June 2022

Abstract
To improve the accuracy of thermal characteristics analysis of motorized spindle, an on-line correction model of thermal boundary conditions is proposed based on BP neural network (BPNN), the experimental data and simulation results are used to build the BPNN model to correct the thermal boundary conditions of motorized spindle. A digital twin system for thermal characteristics is developed based on the co-simulation of Ansys, Matlab, and LabVIEW to accurately predict the temperature field and thermal deformation of motorized spindle under different working conditions. The experimental results show that the prediction accuracy of temperature field accuracy of the motorized spindle is 98.62%, and the prediction accuracy of thermal deformation is 96.06%, which effectively improves the simulation accuracy of thermal characteristics, and provides the basis for the error compensation and thermal optimization design.