bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between dietary total antioxidant capacity and odds and severity of irritable bowel syndrome among Iranian adults: a cross-sectional study
Authors: Saneie Solaleh , Shidfar Farzad , Aminianfar Azadeh , Keshteli Ammar Hassanzadeh , Esmaillzadeh Ahmad , Adibi Peyman 
Published: April 2022

Abstract
Background: Little evidence is available in terms of the role of dietary antioxidants in the management of irritable bowel syndrome (IBS) disease. This study aimed to examine the association between dietary total antioxidant capacity (dTAC) and odds of IBS and its severity. Methods: This cross-sectional study was conducted on 3,362 Iranian adults who were referred to health centers of Isfahan province, Iran. Participant's dietary intakes were collected using a semi-quantitative validated food frequency questionnaire (DS-FFQ). dTAC was measured by the ferric-reducing antioxidant power (FRAP) method. Multivariable binary or ordinal logistic regression analyses were performed to estimate any associations between dTAC and odds of IBS and its severity. Results: The average age and BMI of the participants and dTAC score were 36.3 ± 7.87, 24.9 ± 3.82 and 7.81 ± 3.45, respectively. In crude and adjusted models, the results did not show any significant association between dTAC and odds of IBS among whole and gender-age stratified populations. Being in the third compared with the first category of dTAC was not also significantly associated with odds of IBS severity. Besides, there were no significant associations between dTAC and odds of IBS with constipation, IBS with diarrhea, IBS mixed subtype, and Unsubtyped IBS, respectively.Conclusion: This study indicates that dTAC may not be associated with odds of IBS and its severity even after stratification for gender and body mass index.
Evaluation of Gentamicin Dosage Regimen and Route of Administration Based on Achieved Serum Concentrations in Neonates
Authors: Lim Chuan Poh , Candra Samuel Rocky , Edison Priyantha Ebenezer , Tan Mary Grace , Yong Amanda Mei Hui , Chen Yufei , Yeo Cheo Lian 
Published: April 2022

Abstract
Purpose: Combination antibiotics consisting beta-lactam and aminoglycoside are commonly utilized in the treatment of neonatal septicaemia. The aims of this study were (1) to determine safety and efficacy of the revised gentamicin dosage regimen and (2) to compare intravascular (IV) versus intramuscular (IM) route of gentamicin administration, in term of attaining peak and trough serum concentration targets. Methods: This was a retrospective study from 2012 to 2017. All neonates who received gentamicin with therapeutic drug monitoring performed were included in this study. Data for all eligible neonates were collected from electronic medical records and included demographics, serum creatinine levels, the complete gentamicin dosing and concentration history. Results: A total of 737 neonates who received the correct institutional gentamicin dosage regimen (± 5% of the intended dose) were included in this study. There were 635 trough concentrations (within 30 minutes prior to subsequent dose) and 430 peak concentrations (60 to 90 minutes post administration) included in the comparison of IV and IM route of administration. With the revised dosage regimen, 91% of peak and 98% of trough concentrations were found within therapeutic range. There was no difference in terms of proportion of trough concentrations within therapeutic range for IV as compared to IM (97.8 vs 98.6%, p = 0.556) while IM resulted in a higher proportion of peak concentrations within therapeutic range (86.1 vs 97.0%, p < 0.001). Conclusions: The current institutional gentamicin dosage regimen is safe and effective in attaining therapeutic targets. Intramuscular injection can be an alternative route of administration for gentamicin in neonates.
Does Land Use Influence Plant Diversity and Soil Properties in Watershed Ecosystem?
Authors: OLAJUYIGBE Samuel Olalekan , AGWU Onyebuchi Patrick , BABALOLA Kehinde Daniel 
Published: April 2022

Abstract
Sustainably managed watershed ecosystems play vital roles in ecological stability and contribute to livelihood sustenance. Unfortunately, most watershed ecosystems are threatened by anthropogenic activities such as arable crop cultivation, and infrastructural development. This study investigated the influence of land use on soil physicochemical properties and floristic composition in the watershed of a man-made reservoir (Awba dam). A systematic random sampling technique was used to lay plots (25m by 25m) in alternate positions on identified land use types. Plant species were enumerated and composite soil samples (0-25 cm depth) were collected from four quadrants in each sample plot. Descriptive statistics and diversity indices were computed, and principal component analysis were used to assess the relationship among the variables. Land-use significantly influenced soil chemical properties. Soil from the secondary regrowth had the highest pH (6.25), grassland had the highest organic carbon content (1.95%) while wetland had the highest available phosphorus (40.90 %). There was a significant relationship between species diversity and soil physicochemical properties. A positive relationship was observed between the species dominance, evenness indices with sodium Fe, potassium and calcium. The analysis also revealed that manganese, acidity, and sodium content in soil were more associated with farmland, availability of phosphorus in soil soil PH and high species diversity are more associated with riparian forest, while number of species occurrence are associated with secondary regrowth in the area. This study had revealed that land use system influenced tree species diversity and soil properties in the watershed ecosystem. Therefore, appropriate measures are needed to ensure the survival of key tree species in the watershed to help maximize the structural and functional role of the ecosystem.
Is the QRS duration useful for determining the optimal timing of pulmonary valve replacement after tetralogy of Fallot repair?
Authors: Sugiura Junya , Uchita Shunji , Kojima Ai , Akazawa Yusuke , Takata Hidemi , Nakamura Masashi , Higaki Takashi , Izutani Hironori 
Published: April 2022

Abstract
In pulmonary valve replacement (PVR) after tetralogy of Fallot (TOF) repair, it is recommended that PVR be performed before the right ventricular end-diastolic volume index (RVEDVI) reaches 170 ml/m2 on cardiac magnetic resonance imaging (cMRI) to normalize the RV volume after PVR. We examined the utility of QRS duration, cardiothoracic ratio (CTR), and plasma brain natriuretic peptide (BNP) as markers of an enlarged RV volume to perform PVR at the optimal timing. We assessed the correlation of QRS duration, CTR, and BNP with RVEDVI and RVESVI on cMRI in 26 patients after TOF repair. Fifteen patients underwent PVR (age, 45.2 ± 11.4 years). The RV volume changes from before to after PVR were investigated. Twelve patients underwent post-PVR cMRI. QRS duration, BNP, and CTR were positively correlated with RVEDVI and RVESVI after TOF repair. The post-PVR QRS duration was also positively correlated with post-PVR RVEDVI (p = 0.017) and RVESVI (p = 0.001). From before to after PVR, in cases with QRS duration ≤ 160 ms, the QRS duration decreased from 110.4 ± 28.9 to 101.8 ± 30.5 ms (p = 0.063). Both RVEDVI and RVESVI decreased to the normal range in 4 of 5 cases. In contrast, in cases with QRS duration > 160 ms, the QRS duration decreased from 183.0 ± 17.4 to 160.3 ± 23.8 ms (p = 0.013); however, RVESVI did not normalize in 6 of 7 cases. A prolonged QRS duration is a useful marker of RVEDVI and RVESVI enlargement after TOF repair. A QRS duration of 160 ms is a sensitive cutoff value for predicting RV volume normalization after PVR.
Insufficient bone and high sclerostin in non-functioning pituitary adenoma Is it non-functioning?
Authors: Pekkolay Zafer , Yıldırım Devran Varhan , Tuzcu Şadiye Altun , Taşdemir Bekir , Tuzcu Alpaslan Kemal 
Published: April 2022

Abstract
Purpose: Sclerostin reduces bone formation by inhibiting the Wnt signaling pathway in bone tissue. This study evaluated the serum sclerostin level in non-functioning pituitary adenoma (NFPA) patients and analyzed its relationship with bone metabolism. Method: The data of the patients who applied to the Dicle University Endocrinology, diagnosed with non-functioning pituitary adenoma, and the control group consisting of healthy individuals were included in the study. Serum sclerostin levels and DXA analysis parameters were evaluated and compared with healthy control groups. Results: The study consisted of 39 patients (F / M: 27/12) with NFPA (patient group) and 43 control groups (F / M: 26/17). There was no difference in terms of gender, age, height, weight and serum calcium, phosphorus, creatinine, 25-OH vitamin D, parathyroid hormone levels. Serum sclerostin levels (32.31 ± 1.53 ng / ml) in the patient group was found to be significantly higher than the control group (22.45 ± 8.9 ng / ml) (p <0.001). BMD (Patients groups vs control group); total lumbar BMD (0.951-1.56 gr / cm2) (p <0.001), femoral neck BMD (0.752-1.15 g / cm2) (p <0.001), femoral total BMD (0.995- 1.63 gr / cm2) (p <0.001), were found to be statistically significantly lower. Conclusion: This study provides the first evidence that serum sclerostin levels were increased in non-functioning pituitary adenomas, which showed that bone parameters were negatively affected.
Surgical Resection Predicts Overall Survival even in Frail Patients with IDH- wildtype Glioblastomas
Authors: Elia Angela , Bertuccio Alessandro , Vitali Matteo , Barbanera Andrea , Pallud Johan 
Published: April 2022

Abstract
Purpose
The aim of this study was to evaluate the role of frailty required in the surgical risk assessment in old patients with IDH-wildtype glioblastoma on surgical outcome, overall survival, and functional dependency.
Methods
We reviewed records of old and frail patients surgical treated at our institution between January 2018 to May 2021. Inclusion criteria were : 1) neuropathological diagnosis of IDH-wildtype glioblastoma; 2) patient older than 65 years at the time of surgery; 3) available data to assess the frailty index according to the 5-mFI.
Results
A total of 47 patients were included. The 5-mFI was at 0 in 11 cases (23.4%), at 1 in 30 cases (63.83%), at 2 in 2 cases (4.25%), at 3 in 2 cases (4.25%), at 4 in 2 cases (4.25%). A GTR was performed in 26 patients (55.3%), a STR was performed in 13 patients (27.6%), and a B was performed in 8 patients (17.1%). The rate of 30-day postoperative complications was higher in B and in the 5-mFI = 4 subgroup (p > 0.05). GTR and age ≤ 70 years were independent predictors of a longer overall survival (p < 0.005). Sex, 5-mFI, postoperative complications, and preoperative KPS status did not independently influence overall survival and functional dependency.
Conclusion
In aged patients with IDH-wildtype glioblastoma, GTR is still an independent predictor of longer survival and good postoperative functional recovery whatever the frailty index. The 5-mFI score does not influence surgery and outcomes. Further confirmatory analyses are required.
Malignant transformation of bronchiole adenoma into invasive mucinous adenocarcinoma: a case report and literature review
Authors: Li Peng , Liu Xuling , Li Min , Miao Chengfeng , Sun Wenwen , Yang Kaiyan 
Published: April 2022

Abstract
Background: Bronchiolar adenoma (BA)/ciliated muconodular papillary tumors (CMPTs) was previously considered to be a benign neoplasm, with the possibility of malignant transformation reported in a few cases. Thus, the exact nature and biological potential of BA/CMPT have not been fully elucidated. We here report a case of mucinous adenocarcinoma (MA) caused by malignant transformation of BA. Case presentation: A 57-year-old woman presented with a 17.0×7.0 mm nodule in the lower lobe of the left lung. Hematoxylin-eosin (H&E) staining and immunohistochemistry were performed. The tumor was composed of two areas: BA area and MA area. In BA area, the tumor was consisted by a bilayered structure of luminal cells and basal cells. Basal cells were positive for CK5/6, p63, and p40, while they were not detected in MA area. The Ki-67 proliferation index was low (1%~2%). Finally, the patient was diagnosed with BA accompanied by MA, and had a favourable outcome.Conclusions: BA is generally considered to be a benign tumor. The present study indicated that BA may be carcinogenic and we should be vigilant for its potentiality of malignant transformation in clinical practice.
The Increase in Sagittal Sinus Size in Multiple Sclerosis: Elevated Venous Pressure or Increased Wall Stiffness, a Feasibility Study
Authors: Bateman Grant Alexander , Lechner-Scott Jeannette , Bateman Alexander 
Published: April 2022

Abstract
The cross-sectional area of the superior sagittal sinus (SSS) is larger in multiple sclerosis than normal and correlates with disease severity and progression. The sinus could be enlarged due to a decrease in the pressure difference between the lumen and the subarachnoid space, an increase in wall thickness or increased wall stiffness. The cross-sectional area of the SSS and straight sinus (ST) were measured in 103 patients with multiple sclerosis and compared to 50 controls. The cross-sectional area of the SSS and ST were increased by 20% and 13% compared to the controls (p = 0.005 and 0.02 respectively). The deflection of the wall of the sinus was estimated. The change in pressure gradient, wall thickness or elastic modulus between groups was calculated by modelling the walls as simply supported beams. To account for these findings, the modelling suggests either a 70% reduction in transmural venous pressure or a 3 fold increase in SSS wall stiffness plus an 11% increase in wall thickness. An increase in sinus pressure, although the most straight forward possibility to account for the change in sinus size, may be the least feasible. An increase in sinus wall stiffness and thickness may need further investigation.
Increased expression levels of DLX5 inhibit the development of the nervous system
Authors: Liao# Tingting , Xu# Xia , Wu Junzi , Xie Yi , Yan Jianying 
Published: April 2022

Abstract
Introduction: Preeclampsia (PE) is a hypertensive disorder of pregnancy (HDP). DLX5 plays an important role in the migration and differentiation of subglobus pallidus precursor cells. Material and methods: We established a zebrafish line expressing high levels of DLX5 and investigated changes in behavior and development of the nervous system. Results: The ratios of brain volume area to whole body area at 96 hpf zebrafish in the experimental group (gRNA+CasRx) were significantly lower than the WT group and the negative control group (casRx)(P<0.01). Behavioral trajectory distances and movement speeds exhibited by the 6th day of development in zebrafish in the experimental group (gRNA+CasRx) were significantly shorter (P<0.01) and lower (P<0.05) than the negative control group (gRNA+CasRx), respectively. Conclusions: Data suggested that the increased expression levels of DLX5 can inhibit brain volume development and behavioral activities in zebrafish. Maybe the high expression levels of DLX5 in the pathological state of PE can inhibit the development of the nervous system in offspring.
Induced polyubiquitination of proteins mediated by overexpression of a peptide: a novel tool for targeted protein degradation (TPD) research.
Authors: Nallur Girish 
Published: April 2022

Abstract
A novel strategy for targeting proteins with peptides which give rise to stable ubiquitination has been identified with proteomics. Several bioactive peptides gave rise to characteristic patterns of polyubiquitinated proteins, containing distinct sets of proteins in a cell culture model. Differential mass spectrometry of the ubiquitin-conjugated proteins with one such peptide namely, VB-009, identified proteins predominantly having roles in RNA metabolism, including some that are frequently mutated in diseases, such as, Amyotropic Lateral Sclerosis, Fronto-Temporal Dementia, and myelodysplastic syndrome. The applications of this serendipitous finding for targeting specific targets in TPD are discussed.
Biofuel pellets from spent coffee grounds
Authors: Smirnov Yuri , Sverchkov Ivan , Gabdullina Rushaniya 
Published: April 2022

Abstract
The research is aimed at solving the urgent problem of food industry waste disposal on the example of using spent coffee grounds. The storage of coffee industry waste leads to the loss of potentially valuable raw materials. As one of the most promising solutions, this article considers the use of coffee grounds as the main component for fuel composition with the addition of a binder in the form of crushed cardboard and paper waste. The elemental composition, physical and mechanical properties of fuel pellets and the highest specific heat of coffee biomass and fuel composition based on it were determined in the laboratory studies. It is shown that the waste from coffee production is low in ash and has a high fuel cell content, as well as a high specific heat of combustion. The use of spent coffee grounds as raw materials for biofuel pellets production can be considered as an effective way of processing spent coffee grounds and increasing the value of coffee industry waste.
The synergistic effect of bone marrow mesenchymal stem cells combined with estrogen on repairing rabbit endometrial injury and inhibiting EMT via Wnt/β-catenin pathway
Authors: Yuan Liwei , Cao Jia , Hu Mingyue , Xu Dabao , Li Yan , Zhao Shiyun , Yuan Juanjuan , Zhang Huixing , Huang Yani , Jin He , Chen Meixia , Liu Dan 
Published: April 2022

Abstract
Background
Intrauterine adhesion (IUA) caused by endometrial injury is one of the main causes of female infertility. Bone marrow mesenchymal stem cells (BMSCs) transplantation and estrogen therapy are both promising methods to improve injury. This paper aims to exploring their synergistic effect on repairing rabbit thin endometrium and the possible underlying mechanism of restoring the endometrium morphology.
Methods
The IUA animal model was established by a dual damage method of mechanical curettage and lipopolysaccharide infection. Seventy-five female rabbits were randomly assigned to five groups: sham operation group, IUA model group, BMSCs group, estrogen group and BMSCs plus estrogen group. The number of endometrial glands and the degree of fibrosis were observed by H&E and Masson staining respectively. The expression in markers of fibrosis and EMT were detected using western blotting and immunohistochemistry staining. Additionally, we investigated the distribution and differentiation of PKH26-labeled BMSCs using CK7 as an epithelial marker and Vimentin as a stromal marker by immunofluorescence staining. Finally, western blotting is taken to determine the protein expression of core molecules of Wnt/β-catenin pathway in uterine tissues.
Results
The number of endometrial glands was significantly increased, whereas the area of endometrial fibrosis was decreased in all the treatment groups, with the best effects observed in the BMSCs plus estrogen group. Moreover, downregulated expression of fibrosis markers (fibronectin, CollagenI, a-SMA) and interstitial markers (ZEB1, Vimentin, N-cadherin), as well as upregulated E-cadherin expression were found in the combined group. Further studies showed that the PKH26-labeled BMSCs cells appeared in the endometrial glands and extracellular matrix area when orthotopic transplantation into the uterine cavity. And the abundance of CK7 was increased and Vimentin expression was decreased in the combination treatment group. Additionally, the protein levels of β-catenin, Axin2, C-myc, CycinE of Wnt/β-catenin pathway were higher in the BMSCs combined with estrogen group than in the other treatment groups.
Conclusion
Our study demonstrates that the synergistic effect of BMSCs combined with estrogen therapy in the treatment of injured endometrium is likely to be achieved by inhibiting EMT and activating the Wnt/β-catenin pathway, and represent a promising target for the female infertility.
Innovative Environment in Public Catering
Authors: Gornikov Nikolaj , Mayurnikova Larisa , Novoselov Sergey , Krapiva Tatyana , Koksharov Arkadiy 
Published: April 2022

Public catering is a very specific sphere with a number of factors that hinder innovative development. As a result, local public catering businesses require innovative elements that would be tailored for their needs. The research objective was to analyze the prospects of the public catering industry in the Kemerovo Region and design an instrument for its innovative environment.
The research featured public catering enterprises, food industry universities, consumers, and market, as well as related products, services, and technologies. It also involved such elements of local innovation infrastructure as business incubators, technology transfer centers, core facility centers, and industry-specific innovation clusters. The analysis relied on such basic methods as analysis, generalization, systematization, and synthesis.
State regulation stimulates research and innovative activity by financing projects in priority areas of science and technology. For example, programs UMNIK and START choose applicants with the best innovative project. These programs need new methods of selecting the winners and organizing their cooperation. The research offers a stage-by-stage mechanism of interaction, goal setting, and decision making. The infrastructure elements belonged to the innovation cycle: a student business incubator, an Infopark, a core facility center, a technology transfer center, and a industry-specific cluster. Industry-specific clusters proved effective for the public catering sector.
Innovative activity makes sense when it is integrated with universities and regional infrastructure. Regional food catering infrastructure needs innovative elements and innovative projects, and industry-specific clusters can bring these novelties to the market.
Optimasi Algoritma Data Mining Menggunakan Backward Elimination untuk Klasifikasi Penyakit Diabetes
Authors: Wiratama Muhammad Abid , Pradnya Windha Mega 
Published: April 2022

Diabetes Mellitus (DM) adalah penyakit metabolik kronis yang ditandai dengan peningkatan kadar gula darah, yang dengan seiring berjalannya waktu akan menyebabkan kerusakan pada organ tubuh lainnya. Menurut situs resmi Word Health Organization (WHO) sekitar 422 juta orang di seluruh dunia menderita diabetes. Di Indonesia sendiri menurut situs databox, Indonesia menempati urutan ke-5 kasus diabetes terbanyak di dunia. Keterlambatan dalam diagnosis penyakit diabetes adalah satu penyebab terjadinya lonjakan jumlah kematian maka dari itu tindakan awal yang harus dilakukan adalah deteksi dini.. Dari banyaknya kasus tersebut maka dihasilkan data pasien diabetes yang dapat diolah. Tujuan penelitian ini adalah untuk mengetahui algoritma klasifikasi terbaik dari akurasi dan nilai AUC tertinggi untuk melakukan deteksi dini penyakit diabetes. Algoritma yang akan teliti adalah algoritma KNN, Naïve Bayes, dan C4.5. Algoritma akan dilakukan optimasi menggunakan metode backward elimination. Metode penelitian penelitian ini akan diselesaikan menggunakan metode CRISP-DM. Hasil penelitian adalah model sebelum dioptimasi adalah algoritma KNN akurasi 92,8% dan auc 0,942, algoritma Naïve Bayes akurasi 88,0% dan auc 0,912, , algoritma C4.5 akurasi 96,7% dan auc 0,956, sedangkan hasil model setelah dioptimasi adalah algoritma KNN akurasi 97,6%dan auc 0,973, algoritma Naïve Bayes akurasi 89,4% dan auc 0,958, algoritma C4.5 akurasi 97,5% dan auc 0,988. Kesimpulan dari penilitian ini adalah algoritma terbaik dari akurasi adalah algoritma KNN yang sudah dioptimasi dengan akurasi 0,976 dan dari auc yang dihasilkan adalah algoritma C4.5 yang sudah dioptimasi dengan nilai auc 0,988.