bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells
Authors: Lynall Mary-Ellen , Soskic Blagoje , Hayhurst James , Schwartzentruber Jeremy , Levey Daniel F. , Pathak Gita A. , Polimanti Renato , Gelernter Joel , Stein Murray B. , Trynka Gosia , Clatworthy Menna R. , Bullmore Ed 
Published: October 2022

AbstractMultiple psychiatric disorders have been associated with abnormalities in both the innate and adaptive immune systems. The role of these abnormalities in pathogenesis, and whether they are driven by psychiatric risk variants, remains unclear. We test for enrichment of GWAS variants associated with multiple psychiatric disorders (cross-disorder or trans-diagnostic risk), or 5 specific disorders (cis-diagnostic risk), in regulatory elements in immune cells. We use three independent epigenetic datasets representing multiple organ systems and immune cell subsets. Trans-diagnostic and cis-diagnostic risk variants (for schizophrenia and depression) are enriched at epigenetically active sites in brain tissues and in lymphoid cells, especially stimulated CD4+ T cells. There is no evidence for enrichment of either trans-risk or cis-risk variants for schizophrenia or depression in myeloid cells. This suggests a possible model where environmental stimuli activate T cells to unmask the effects of psychiatric risk variants, contributing to the pathogenesis of mental health disorders.
Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern
Authors: van Rijswijck Danique M. H. , Bondt Albert , Hoek Max , van der Straten Karlijn , Caniels Tom G. , Poniman Meliawati , Eggink Dirk , Reusken Chantal , de Bree Godelieve J. , Sanders Rogier W. , van Gils Marit J. , Heck Albert J. R. 
Published: October 2022

AbstractExisting assays to measure antibody cross-reactivity against different SARS-CoV-2 spike (S) protein variants lack the discriminatory power to provide insights at the level of individual clones. Using a mass spectrometry-based approach we are able to monitor individual donors’ IgG1 clonal responses following a SARS-CoV-2 infection. We monitor the plasma clonal IgG1 profiles of 8 donors who had experienced an infection by either the wild type Wuhan Hu-1 virus or one of 3 VOCs (Alpha, Beta and Gamma). In these donors we chart the full plasma IgG1 repertoires as well as the IgG1 repertoires targeting the SARS-CoV-2 spike protein trimer VOC antigens. The plasma of each donor contains numerous anti-spike IgG1 antibodies, accounting for <0.1% up to almost 10% of all IgG1s. Some of these antibodies are VOC-specific whereas others do recognize multiple or even all VOCs. We show that in these polyclonal responses, each clone exhibits a distinct cross-reactivity and also distinct virus neutralization capacity. These observations support the need for a more personalized look at the antibody clonal responses to infectious diseases.
An ultra-high gain single-photon transistor in the microwave regime
Authors: Wang Zhiling , Bao Zenghui , Li Yan , Wu Yukai , Cai Weizhou , Wang Weiting , Han Xiyue , Wang Jiahui , Song Yipu , Sun Luyan , Zhang Hongyi , Duan Luming 
Published: October 2022

AbstractA photonic transistor that can switch or amplify an optical signal with a single gate photon requires strong non-linear interaction at the single-photon level. Circuit quantum electrodynamics provides great flexibility to generate such an interaction, and thus could serve as an effective platform to realize a high-performance single-photon transistor. Here we demonstrate such a photonic transistor in the microwave regime. Our device consists of two microwave cavities dispersively coupled to a superconducting qubit. A single gate photon imprints a phase shift on the qubit state through one cavity, and further shifts the resonance frequency of the other cavity. In this way, we realize a gain of the transistor up to 53.4 dB, with an extinction ratio better than 20 dB. Our device outperforms previous devices in the optical regime by several orders in terms of optical gain, which indicates a great potential for application in the field of microwave quantum photonics and quantum information processing.
Spray-coated perovskite hemispherical photodetector featuring narrow-band and wide-angle imaging
Authors: Feng Xiaopeng , He Yuhong , Qu Wei , Song Jinmei , Pan Wanting , Tan Mingrui , Yang Bai , Wei Haotong 
Published: October 2022

AbstractSphere imagers featuring specific wavelength recognition and wide-angle imaging are required to meet the fast development of modern technology. However, it is still challenging to deposit high-quality photosensitive layers on sphere substrates from low-cost solution processes. Here we report spray-coated quasi-two-dimensional phenylethylammonium/formamidinium lead halide (PEA2FAn-1PbnX3n+1) perovskite hemispherical photodetectors. The crystallization speed is manipulated by perovskite compositions, and the film thickness can be controlled by spray-coating cycles and solution concentration from tens of nanometers to hundreds of micrometers with a fast velocity of 1.28 × 10−4 cm3 s−1. The lens-free hemispherical photodetectors allow light response at a wide incident angle of 180°. Simultaneously, the wavelength selective response from visible to the near-infrared range is achieved with full width at half maximums (FWHMs) of ~20 nm, comparable to single-crystal devices. Wide-angle and wavelength-selective imaging are also demonstrated, which can find potential applications in intelligent recognition and intraoperative navigated surgery.
The gut microbiome-metabolome dataset collection: a curated resource for integrative meta-analysis
Authors: Muller Efrat , Algavi Yadid M. , Borenstein Elhanan 
Published: October 2022

AbstractIntegrative analysis of microbiome and metabolome data obtained from human fecal samples is a promising avenue for better understanding the interplay between bacteria and metabolites in the human gut, in both health and disease. However, acquiring, processing, and unifying such datasets from multiple sources is a daunting and challenging task. Here we present a publicly available, simple-to-use, curated dataset collection of paired fecal microbiome-metabolome data from multiple cohorts. This data resource allows researchers to easily obtain multiple fully processed and integrated microbiome-metabolome datasets, facilitating the discovery of universal microbe-metabolite links, benchmark various microbiome-metabolome integration tools, and compare newly identified microbe-metabolite findings to other published datasets.
Experimental demonstration of entanglement delivery using a quantum network stack
Authors: Pompili M. , Delle Donne C. , te Raa I. , van der Vecht B. , Skrzypczyk M. , Ferreira G. , de Kluijver L. , Stolk A. J. , Hermans S. L. N. , Pawełczak P. , Kozlowski W. , Hanson R. , Wehner S. 
Published: October 2022

AbstractScaling current quantum communication demonstrations to a large-scale quantum network will require not only advancements in quantum hardware capabilities, but also robust control of such devices to bridge the gap in user demand. Moreover, the abstraction of tasks and services offered by the quantum network should enable platform-independent applications to be executed without the knowledge of the underlying physical implementation. Here we experimentally demonstrate, using remote solid-state quantum network nodes, a link layer, and a physical layer protocol for entanglement-based quantum networks. The link layer abstracts the physical-layer entanglement attempts into a robust, platform-independent entanglement delivery service. The system is used to run full state tomography of the delivered entangled states, as well as preparation of a remote qubit state on a server by its client. Our results mark a clear transition from physics experiments to quantum communication systems, which will enable the development and testing of components of future quantum networks.
Versatility of live-attenuated measles viruses as platform technology for recombinant vaccines
Authors: Ebenig Aileen , Lange Mona V. , Mühlebach Michael D. 
Published: October 2022

AbstractLive-attenuated measles virus (MeV) has been extraordinarily effective in preventing measles infections and their often deadly sequelae, accompanied by remarkable safety and stability since their first licensing in 1963. The advent of recombinant DNA technologies, combined with systems to generate infectious negative-strand RNA viruses on the basis of viral genomes encoded on plasmid DNA in the 1990s, paved the way to generate recombinant, vaccine strain-derived MeVs. These live-attenuated vaccine constructs can encode and express additional foreign antigens during transient virus replication following immunization. Effective humoral and cellular immune responses are induced not only against the MeV vector, but also against the foreign antigen cargo in immunized individuals, which can protect against the associated pathogen. This review aims to present an overview of the versatility of this vaccine vector as platform technology to target various diseases, as well as current research and developmental stages, with one vaccine candidate ready to enter phase III clinical trials to gain marketing authorization, MV-CHIK.
Integrated database for economic complexity
Authors: Patelli Aurelio , Pietronero Luciano , Zaccaria Andrea 
Published: October 2022

AbstractWe present an integrated database suitable for the investigation of the economic development of countries by using the Economic Fitness and Complexity framework. Firstly, we implement machine learning techniques to reconstruct the export flow of services and we combine them to the export flow of the physical goods, generating a complete view of the international market, denoted the Integrated database. Successively, we support the technical quality of the database by computing the main metrics of the Economic Fitness and Complexity framework: (i) we build a statistically validated network of economic activities, where preferred paths of development and clusters of High-Tech industries naturally emerge; (ii) we evaluate the Economic Fitness, an algorithmic assessment of the competitiveness of countries, removing the unexpected misbehaviour of economies under-represented by the sole consideration of the export of the physical goods.
Synthesizing realistic high-resolution retina image by style-based generative adversarial network and its utilization
Authors: Kim Mingyu , Kim You Na , Jang Miso , Hwang Jeongeun , Kim Hong-Kyu , Yoon Sang Chul , Kim Yoon Jeon , Kim Namkug 
Published: October 2022

AbstractRealistic image synthesis based on deep learning is an invaluable technique for developing high-performance computer aided diagnosis systems while protecting patient privacy. However, training a generative adversarial network (GAN) for image synthesis remains challenging because of the large amounts of data required for training various kinds of image features. This study aims to synthesize retinal images indistinguishable from real images and evaluate the efficacy of the synthesized images having a specific disease for augmenting class imbalanced datasets. The synthesized images were validated via image Turing tests, qualitative analysis by retinal specialists, and quantitative analyses on amounts and signal-to-noise ratios of vessels. The efficacy of synthesized images was verified by deep learning-based classification performance. Turing test shows that accuracy, sensitivity, and specificity of 54.0 ± 12.3%, 71.1 ± 18.8%, and 36.9 ± 25.5%, respectively. Here, sensitivity represents correctness to find real images among real datasets. Vessel amounts and average SNR comparisons show 0.43% and 1.5% difference between real and synthesized images. The classification performance after augmenting synthesized images outperforms every ratio of imbalanced real datasets. Our study shows the realistic retina images were successfully generated with insignificant differences between the real and synthesized images and shows great potential for practical applications.
An efficiency strategy for cobalt recovery from simulated wastewater by biphasic system with polyethylene glycol and ammonium sulfate
Authors: Amjad Razieh Sobhi , Asadollahzadeh Mehdi , Torkaman Rezvan , Torab-Mostaedi Meisam 
Published: October 2022

AbstractToday, biphasic aqueous systems have received more attention than conventional separation methods due to their advantages, such as biocompatibility, low cost, and easy operation. The extraction of cobalt ions from the aqueous phase with the absence and the presence of other ions was investigated using polyethylene glycol, and ammonium sulfate salt without using an extractant. The efficiency was evaluated using operating parameters such as aqueous pH, salt and polymer concentrations, phase volume ratio, and initial metal concentration. The higher temperature, and the lower aqueous pH showed a maximum transfer rate for cobalt ions into the PEG1000 phase. Extraction efficiency under optimal conditions equal to 50% (w/w) polyethylene glycol 1000, 4 M ammonium sulfate, aqueous pH = 2, and 15 min extraction time was over 98%. Results from infrared spectroscopy, and thermo-gravimetric analysis illustrated the presence of the PEG-cobalt ion complex. The observation demonstrated that the biphasic system is the proper technology for wastewater purification.
Effects of a catechins-enriched diet associated with moderate physical exercise in the prevention of hypertension in spontaneously hypertensive rats
Authors: Del Seppia Cristina , Federighi Giuseppe , Lapi Dosminga , Gerosolimo Federico , Scuri Rossana 
Published: October 2022

AbstractHypertension represents the main risk factor for the onset of cardiovascular diseases. Pharmacological treatments to control hypertension have been associated with new treatments involving physical activity and/or the intake of natural components (nutraceuticals). We here report the effects produced by a combination of a natural component (catechins) and a moderate exercise program on the development of hypertension in spontaneous hypertensive rats compared with those of each individual treatment. Arterial blood pressure and heart rate were measured with a non-invasive method in 28 rats randomly assigned to four groups: rats subjected to moderate physical exercise; rats with a catechins-enriched diet; rats subjected to moderate physical exercise combined with a catechins-enriched diet; control, untreated-rats left to age. All treatments were applied for 6 weeks. The statistical analysis revealed that the three treatments significantly reduced the weekly increase in arterial blood pressure observed in control rats (SBP, P < 0.0001; DBP, P = 0.005). However, the reduction of arterial blood pressure induced by combined treatments was not higher than that induced by the single treatment, but more prolonged. All treatments showed strong antioxidative properties. Our data show that physical activity and a diet enriched with catechins individually have an important hypotensive effect, while the association did not produce a higher hypotensive effect than the single treatment, even if it was able to decrease blood pressure for a longer time. These findings have important implications for developing a protocol to apply in novel hypertension prevention procedures.
Marine heatwaves of different magnitudes have contrasting effects on herbivore behaviour
Authors: Joyce Patrick W. S. , Tang Wing Yee , Falkenberg Laura J. 
Published: October 2022

AbstractGlobal climate change is leading to shifts in abiotic conditions. Short-term temperature stresses induced by marine heatwaves (MHWs) can affect organisms both during and after the events. However, the recovery capacity of organisms is likely dependent on the magnitude of the initial stress event. Here, we experimentally assessed the effect of MHW magnitude on behavioural and physiological responses of a common marine gastropod, Lunella granulata, both during and after the MHW. Self-righting behaviours tended to become faster under moderate MHWs, whereas there was a trend toward these behaviours slowing under extreme MHWs. After a recovery period at ambient temperatures, individuals that experienced extreme MHWs showed persistent small, but not significant, negative effects. Survival and oxygen consumption rates were unaffected by MHW magnitude both during and after the event. While extreme MHWs may have negative behavioural consequences for tropical marine gastropods, their physiological responses may allow continued survival.
Lateral confined growth of cells activates Lef1 dependent pathways to regulate cell-state transitions
Authors: Yuan Luezhen , Roy Bibhas , Ratna Prasuna , Uhler Caroline , Shivashankar G. V. 
Published: October 2022

AbstractLong-term sustained mechano-chemical signals in tissue microenvironment regulate cell-state transitions. In recent work, we showed that laterally confined growth of fibroblasts induce dedifferentiation programs. However, the molecular mechanisms underlying such mechanically induced cell-state transitions are poorly understood. In this paper, we identify Lef1 as a critical somatic transcription factor for the mechanical regulation of de-differentiation pathways. Network optimization methods applied to time-lapse RNA-seq data identify Lef1 dependent signaling as potential regulators of such cell-state transitions. We show that Lef1 knockdown results in the down-regulation of fibroblast de-differentiation and that Lef1 directly interacts with the promoter regions of downstream reprogramming factors. We also evaluate the potential upstream activation pathways of Lef1, including the Smad4, Atf2, NFkB and Beta-catenin pathways, thereby identifying that Smad4 and Atf2 may be critical for Lef1 activation. Collectively, we describe an important mechanotransduction pathway, including Lef1, which upon activation, through progressive lateral cell confinement, results in fibroblast de-differentiation.
Quantification of diaphragmatic dynamic dysfunction in septic patients by bedside ultrasound
Authors: Chen Yunqiu , Liu Yujia , Han Mingxin , Zhao Shuai , Tan Ya , Hao Liying , Liu Wenjuan , Zhang Wenyan , Song Wei , Pan Mengmeng , Jiao Guangyu 
Published: October 2022

AbstractAlthough diaphragmatic dysfunction is an important indicator of severity of illness and poor prognosis in ICU patients, there is no convenient and practical method to monitor diaphragmatic function. This study was designed to analyze diaphragmatic dynamic dysfunction by bedside ultrasound in septic patients and provide quantitative evidence to assess diaphragm function systematically. This prospective observational study was conducted from October 2019 to January 2021 in the Department of Respiratory and Critical Care Medicine. 74 patients suffered from sepsis were recruited and divided into two groups, sepsis group 1 (2 ≤ SOFA ≤ 5, n = 41) and sepsis group 2 (SOFA > 5, n = 33). 107 healthy volunteers were randomly recruited as the control group. In all participants, the diaphragmatic thickness and excursion were measured directly and the dynamic parameters including thickening fraction (TF), EQB/EDB, Contractile velocity, and area under diaphragmatic movement curve (AUDMC) were calculated by bedside ultrasound during quiet breathing (QB) and deep breathing (DB). Each parameter among three groups was analyzed separately by covariance analysis, which was adjusted by age, sex, body mass index, MAP, hypertension, and diabetes. First, contractile dysfunction occurred before diaphragmatic atrophy both in sepsis group 1 and sepsis group 2. Second, compared with the control group, the dynamic parameters showed significant decrease in sepsis group 1 and more obvious change in sepsis group 2, including TF, EQB/EDB. Third, the maximum contractile velocity decreased in sepsis group 1, reflecting the damage of intrinsic contraction efficiency accurately. Finally, per breathing AUDMC in two septic groups were lower than those in control group. However, per minute AUDMC was compensated by increasing respiratory rate in sepsis group 1, whereas it failed to be compensated which indicated gradual failure of diaphragm in sepsis group 2. Diaphragmatic ultrasound can be used to quantitatively evaluate the severity of sepsis patients whose contractile dysfunction occurred before diaphragmatic atrophy. As dynamic parameters, TF and EQB/EDB are early indicator associated with diaphragmatic injury. Furthermore, maximum contractile velocity can reflect intrinsic contraction efficiency accurately. AUDMC can evaluate diaphragmatic breathing effort and endurance to overcome resistance loads effectively.
Associations between serum mitokine levels and outcomes in stable COPD: an observational prospective study
Authors: Amado Carlos A. , Martín-Audera Paula , Agüero Juan , Lavín Bernardo A. , Guerra Armando R. , Muñoz Pedro , Berja Ana , Casanova Ciro , García-Unzueta Mayte 
Published: October 2022

AbstractMitokines (Humanin (HN), GDF15 and FGF21) are produced as a result of mitochondrial dysfunction and may have major roles in chronic inflammation, malnutrition and exercise capacity in people with COPD. Except for GDF15, studies on this subject are lacking. A total of 165 patients with stable COPD and 49 smokers without COPD were enrolled. We assessed their serum mitokine levels and clinical characteristics at baseline. We recorded moderate and severe exacerbation for the next 12 months. Baseline serum HN (p = 0.037) and GDF-15 (p = 0.013) levels were higher in the COPD group. High HN levels were independently associated with a high risk of exacerbation (HRE) (OR 2.798, 95% CI 1.266–6.187, p = 0.011), malnutrition (OR 6.645, 95% CI 1.859–23.749, p = 0.004), and 6MWD (OR 0.995, 95% CI 0.991–0.999, p = 0.008), and future moderate (HR 1.826, 95% CI 1.181–2.822, p = 0.007) and severe exacerbations (HR 3.445, 95% CI 1.357–8.740, p = 0.009). High GDF15 levels were associated with HRE (OR 3.028, 95% CI 1.134–8.083, p = 0.027), 6MWD (OR 0.995, 95% CI 0.990–0.999, p = 0.017) and predicted desaturation in 6MWT (OR 3.999, 95% CI 1.487–10.757, p = 0.006). High FGF21 levels were associated with HRE (OR 2.144, 95% CI 1.000–4.600, p = 0.05), and predicted future severe exacerbation (HR 4.217, 95% CI 1.459–12.193, p = 0.008). The mitokine levels were higher in patients with COPD than smokers without COPD, and were associated with important clinical outcomes such as exercise capacity and COPD exacerbation. Among the mitokines, HN showed the strongest association with COPD and may serve as a future risk biomarker in this disease.Trial registation NCT04449419.