bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finite Element Conjugate Heat Transfer Strategy for Self and Applied Magnetoplasmadynamic (MPD) Thrusters
Authors: Berry K. J. 
Published: September 2022

Abstract
Conjugate Heat Transfer (CHT) analysis allows for the simulation of heat transfer between solid and fluid domains by exchanging thermal energy at the solid/fluid interfaces. This exchange is especially important for MPD thruster analysis due to the high temperature plasma (∼5000K) heat transfer exchange between the plasma/Cathode and plasma/Anode electrode interfaces. Proper numerical modeling captures both the large electromagnetic current and magnetic field gradients, as well as, the heat transfer thermal gradients, that occur due to large thermal and electrical diffusion coefficient differences at the plasma/solid interface. Although MPD-CHT models are typically not included, attention to such numerical detail yields an improved MPD thruster design process and provides guidance to determine external heat transfer cooling requirements to maintain proper operating parameters. The non-linear coupled finite element formulation herein provides increased stability and presents a computational framework strategy for modeling and analysis of self-field and applied field MPD thrusters considering the highly non-linear, multi-disciplinary, and temperature dependent property requirements of the integrated solid/fluid MPD problem domain. A single numerical modeling design variable (OMEGA) is also introduced that combines experimental and numerical parameters, with reference plasma thermal properties.
Machine Learning Based Control of Multi-Temperature PCM Thermal Storage Assemblies - A Comparison of On/Off Versus Fully Modulating Valve Control
Authors: Cooney Alanna Y. , Carey Van P. 
Published: September 2022

Abstract
Latent thermal energy storage (TES) systems which store energy in a phase change material (PCM) can be used to alleviate disparities in energy supply and demand for a variety of applications from concentrated solar plants to building heating and cooling systems. Furthermore, multiple TES modules containing PCMs with different melt temperatures can be combined in series and parallel configurations to construct a multi-temperature TES assembly to allow for wider flexibility in system optimization. This study demonstrates the feasibility of using machine learning based control methods to operate multi-temperature TES assemblies to ensure both operational reliability and optimization of energy usage. Two different TES assemblies are considered: one with on/off valves controlling flow to individual modules and one with fully modulating valves. Theoretical models are developed to determine the best flow path for the working fluid through each TES assembly for a variety of inlet temperatures and flow rates based on a dual optimization of matching a target outlet temperature and minimizing exergy destruction. Artificial Neural Network (ANN) controllers are then developed for each of the systems to predict the best operating mode based on the inlet temperature and flow rate to the TES assembly. The results demonstrate that an ANN controller can be used to successfully operate a multi-temperature TES assembly and maintain high operational reliability by matching a desired outlet temperature while also improving efficiency by decreasing the fraction of exergy destroyed to total energy transferred.
Large Eddy Simulation of Random Pebble Bed Using the Spectral Element Method
Authors: Nguyen Tri , Merzari Elia , Yuan Haomin , Dai Dezhi , Jackson Brian 
Published: September 2022

Abstract
The evolution of Fluoride-Cooled High-Temperature Reactors (FHRs) that utilize pebble fuel has drastically increased the demand for in-depth understanding of the heat transfer (HT) in packed beds cooled by liquid salts. The complex flow fields found in a pebble bed may require a detailed understanding to ensure the proper cooling of the reactor core during normal and accident conditions. As detailed experimental data is very difficult to obtain for these configurations high fidelity simulation like Large Eddy Simulation (LES) and direct numerical simulation (DNS) can be employed to create a high-resolution HT numerical database that can assist addressing industrial-driven issues associated with the HT behavior of FHRs.
In this paper, we performed a series of LES using the GPU-oriented spectral element CFD code NekRS to investigate the HT for a bed of 1741 pebbles at Reynolds numbers ranging from 50 to 1600 based on coolant (FLiBE) inlet velocity. Two different type of pebble power distribution were used, one with the same power density for all pebble, other with different power density. Non conjugate heat transfer (non-CHT) and conjugate heat transfer (CHT) cases have been performed and characteristics of the flow domain such as average, rms, as well as time series of velocity and temperature have been analyzed. The simulation results show a good agreement between non CHT and CHT. In addition, NekRS data have also been compared with OpenFOAM models. The good agreement has also been achieved which gave the confident of the NekRS/OpenFOAM dataset when little to no empirical data is available. The generated data will be used to benchmark HT modeling methods, local maxima/minima of HT parameters and support convective heat transfer quantification for Kairos Power, validating OpenFOAM models, as well as benchmark lower finality models such as Reynolds Averaged Navier Stokes (RANS) and/or porous media approaches.
Supplemental Material: Foreland basin response to middle Cretaceous thrust belt evolution, southwestern Montana, USA
Authors: Gardner C.T. , al. et , Finzel Emily 
Published: September 2022

<p>Files include measured stratigraphic sections, concordia diagrams for U-Pb detrital zircon data, a multidimensional scaling plot that includes arc ages, SELFRAG mineral separation methods and results, GPS coordinates for samples, R<sup>2</sup> values for mixture model iterations, and raw point count data. </p>
Association of macular vessel density and ganglion cell complex thickness with central visual field progression in glaucoma
Authors: Wu Jo-Hsuan , Moghimi Sasan , Nishida Takashi , Mahmoudinezhad Golnoush , M Zangwill Linda , Weinreb Robert N 
Published: September 2022

Background/aims
To evaluate the association of macular vessel density (VD) and ganglion cell complex (GCC) thickness with 10–2 central visual field (CVF) progression in glaucoma.

Methods
In this retrospective cohort study, patients with glaucoma from Diagnostic Innovation in Glaucoma Study with≥five 10–2 visual field (VF) tests and 3-year follow-up before optical coherence tomography (OCT) and OCT angiography (OCTA) imaging were included. Whole-image GCC thickness (wiGCC) and superficial VD (wiVD) were obtained from 6*6 macula scans. The association of wiVD and wiGCC with past rate of 10–2 VF mean deviation worsening, and with past CVF progression (defined using clustered linear regression criteria) was evaluated using linear mixed models after adjusting for confounders.

Results

From 238 eyes (141 patients), 25 eyes (11%) of 16 patients were CVF progressors. In the multivariable analysis of the association between OCT/OCTA parameters and past rate of 10–2 CVF worsening, lower wiVD (β=−0.04 (–0.05, –0.02); p<0.001; R
2
=0.32) and wiGCC (β=−0.01 (–0.01, 0.00); p=0.004; R
2
=0.21) were significantly associated with faster CVF worsening. For the association between OCT/OCTA parameters and past CVF progression, the multivariable analysis showed that a lower wiVD was significantly associated with increased odds of past CVF progression (OR=1.23 (1.06, 1.44) per 1% lower; p=0.008), while wiGCC did not show correlation.

Conclusions
Lower macular VD and GCC were associated with faster worsening of CVF, and lower macular VD was associated with increased odds of CVF progression. Assessment of macular OCT and OCTA may help detect glaucoma eyes with CVF progression.
Measurements of the degree of development of rigor mortis as an indicator of stress in slaughtered pigs
Authors: Warriss P. D. , Brown S. N. , Knowles T. G. 
Published: September 2022

The degree of development of rigor mortis in the carcases of slaughter pigs was assessed subjectively on a three‐point scale 35 minutes after they were exsanguinated, and related to the levels of cortisol, lactate and creatine kinase in blood collected at exsanguination. Earlier rigor development was associated with higher concentrations of these stress indicators in the blood. This relationship suggests that the mean rigor score, and the frequency distribution of carcases that had or had not entered rigor, could be used as an index of the degree of stress to which the pigs had been subjected.
Targeting OCT2 with Duloxetine to Prevent Oxaliplatin-induced Peripheral Neurotoxicity
Authors: Nepal Mahesh R. , Taheri Hanieh , Li Yang , Talebi Zahra , Uddin Muhammad Erfan , Jin Yan , DiGiacomo Duncan F. , Gibson Alice A. , Lustberg Maryam B. , Hu Shuiying , Sparreboom Alex 
Published: September 2022

Oxaliplatin-induced peripheral neurotoxicity (OIPN) is a debilitating side effect that afflicts approximately 90% of patients that is initiated by OCT2-dependent uptake of oxaliplatin in dorsal root ganglion (DRG) neurons. The antidepressant drug duloxetine has been used to treat OIPN, although its usefulness in preventing this side effect remains unclear. We hypothesized that duloxetine has OCT2-inhibitory properties and can be used as an adjunct to oxaliplatin-based regimens to prevent OIPN. Transport studies were performed in cells stably transfected with mouse or human OCT2 and in isolated mouse DRG neurons ex vivo. Wild-type and OCT2-deficient mice were used to assess effects of duloxetine on hallmarks of OIPN, endogenous OCT2 biomarkers, and the pharmacokinetics of oxaliplatin, and the translational feasibility of a duloxetine-oxaliplatin combination was evaluated in various models of colorectal cancer. We found that duloxetine potently inhibited the OCT2-mediated transport of several xenobiotic substrates, including oxaliplatin, in a reversible, concentration-dependent manner, and independent of species and cell context. Furthermore, duloxetine restricted access of these substrates to DRG neurons ex vivo and prevented OIPN in wild-type mice to a degree similar to the complete protection observed in OCT2-deficient mice, without affecting the plasma levels of oxaliplatin. Importantly, the uptake and cytotoxicity of oxaliplatin in tumor cell lines in vitro and in vivo were not negatively influenced by duloxetine. The observed OCT2-targeting properties of duloxetine, combined with the potential for clinical translation, provide support for its further exploration as a therapeutic candidate for studies aimed at preventing OIPN in patients with cancer requiring treatment with oxaliplatin.Significance:We found that duloxetine has potent OCT2-inhibitory properties and can diminish excessive accumulation of oxaliplatin into DRG neurons. In addition, pretreatment of mice with duloxetine prevented OIPN without significantly altering the plasma pharmacokinetics and antitumor properties of oxaliplatin. These results suggest that intentional inhibition of OCT2-mediated transport by duloxetine can be employed as a prevention strategy to ameliorate OIPN without compromising the effectiveness of oxaliplatin-based treatment.
Circulating Tumor DNA Monitoring Reveals Molecular Progression before Radiologic Progression in a Real-life Cohort of Patients with Advanced Non–small Cell Lung Cancer
Authors: Frank Malene S. , Andersen Christina S.A. , Ahlborn Lise B. , Pallisgaard Niels , Bodtger Uffe , Gehl Julie 
Published: September 2022

Purpose:The clinical potential of liquid biopsy in patients with advanced cancer is real-time monitoring for early detection of treatment failure. Our study aimed to investigate the clinical validity of circulating tumor DNA (ctDNA) treatment monitoring in a real-life cohort of patients with advanced non–small cell lung cancer (NSCLC).Experimental Design:Patients with advanced or noncurative locally advanced NSCLC were prospectively included in an exploratory study (NCT03512847). Selected cancer-specific mutations were measured in plasma by standard or uniquely designed droplet digital PCR assays before every treatment cycle during first-line treatment until progressive disease (PD). Correlation between an increase in ctDNA (= molecular progression) and radiologic PD was investigated, defined as lead time, and the corresponding numbers of likely futile treatment cycles were determined. Utility of ctDNA measurements in clarifying the results of nonconclusive radiologic evaluation scans was evaluated.Results:Cancer-specific mutations and longitudinal plasma sampling were present in 132 of 150 patients. ctDNA was detectable in 88 (67%) of 132 patients treated by respectively chemotherapy (n = 41), immunotherapy (n = 43), or combination treatment (n = 4). In 66 (90%) of 73 patients experiencing PD, a ctDNA increase was observed with a median lead time of 1.5 months before radiologic PD. Overall, 119 (33%) of 365 treatment cycles were administered after molecular progression. In addition, ctDNA measurements could clarify the results in 38 (79%) of 48 nonconclusive radiologic evaluations.Conclusions:ctDNA monitoring leads to earlier detection of treatment failure, and clarifies the majority of nonconclusive radiologic evaluations, giving the potential of sparing patients from likely futile treatments and needless adverse events.Significance:Treatment monitoring by ctDNA has the clinical potential to reveal PD before radiologic evaluation and consequently spare patients with advanced cancer from likely ineffective, costly cancer treatments and adverse events.
Prospective Observational Cohort Study of Tenecteplase Versus Alteplase in Routine Clinical Practice
Authors: Warach Steven J. , Dula Adrienne N. , Milling Truman J. , Miller Samantha , Allen Leigh , Zuck Nathan D. , Miller Collin , Jesser Christine A. , Misra Lotika R. , Miley Jefferson T. , Mawla Manzure , Ding Ming-Chieh , Bertelson John A. , Tsui Annie Y. , Jefferson John R. , Davison Holly M. , Shah Darshan N. , Ellington Kent T. , Padrick Matthew M. , Nova Alan S. , Krishna Vivek R. , Davis Lisa A. , Paydarfar David 
Published: September 2022

Background:
A 10-hospital regional network transitioned to tenecteplase as the standard of care stroke thrombolytic in September 2019 because of potential workflow advantages and reported noninferior clinical outcomes relative to alteplase in meta-analyses of randomized trials. We assessed whether tenecteplase use in routine clinical practice reduced thrombolytic workflow times with noninferior clinical outcomes.

Methods:
We designed a prospective registry-based observational, sequential cohort comparison of tenecteplase- (n=234) to alteplase-treated (n=354) stroke patients. We hypothesized: (1) an increase in the proportion of patients meeting target times for target door-to-needle time and transfer door-in-door-out time, and (2) noninferior favorable (discharge to home with independent ambulation) and unfavorable (symptomatic intracranial hemorrhage, in-hospital mortality or discharge to hospice) in the tenecteplase group. Total hospital cost associated with each treatment was also compared.

Results:

Target door-to-needle time within 45 minutes for all patients was superior for tenecteplase, 41% versus 29%; adjusted odds ratio, 1.85 (95% CI, 1.27–2.71);
P
=0.001; 58% versus 41% by Get With The Guidelines criteria. Target door-in-door-out time within 90 minutes was superior for tenecteplase 37% (15/43) versus 14% (9/65); adjusted odds ratio, 3.62 (95% CI, 1.30–10.74);
P
=0.02. Favorable outcome for tenecteplase fell within the 6.5% noninferiority margin; adjusted odds ratio, 1.26 (95% CI, 0.89–1.80). Unfavorable outcome was less for tenecteplase, 7.3% versus 11.9%, adjusted odds ratio, 0.77 (95% CI, 0.42–1.37) but did not fall within the prespecified 1% noninferior boundary. Net benefit (%favorable–%unfavorable) was greater for the tenecteplase sample: 37% versus 27%.
P
=0.02. Median cost per hospital encounter was less for tenecteplase cases ($13 382 versus $15 841;
P
<0.001).

Conclusions:
Switching to tenecteplase in routine clinical practice in a 10-hospital network was associated with shorter door-to-needle time and door-in-door-out times, noninferior favorable clinical outcomes at discharge, and reduced hospital costs. Evaluation in larger, multicenter cohorts is recommended to determine if these observations generalize.
Monitoring changes in accumulation of heavy metals in the Egyptian Delta region in 2010 and 2021, using the crayfish Procambarus clarkii (Girard, 1852) (Decapoda, Astacidea) as a bio-indicator
Authors: Younis Mai L. , Mona Mahy M. , Rizk El-Sayed T. , Atlam Aalaa I. 
Published: September 2022

Abstract
Accumulation of heavy metals in tissues of the crayfish Procambarus clarkii and in water were evaluated in areas located in the Egyptian Delta (Gharbiya, Kafr El-Shaikh, and Menofiya) in 2010 and 2021. Statistics showed that in 2010 the highest concentration of heavy metals in the digestive gland and in muscles was Zn, both in Gharbiya and Menofiya, while Fe was the highest accumulated in the digestive gland, and Pb was the highest in muscles of samples from Kafr El-Shaikh. The results showed that heavy metal loads decreased in Kafr El-Shaikh in 2021, whereas Fe increased significantly () in Gharbiya and Menofiya (41.44 ± 2.32, 47.25 ± 2.64 μg/g). Accumulation of Cd and Zn in gills and muscles decreased in all areas from 2010 to 2021, while a significant increase () was shown in Fe and Cu in 2021. All heavy metals significantly decreased () in waters of the studied areas from 2010 to 2021.
“She Has Not Been Seen or Heard of Since”
Authors: Ulentin Anne 
Published: September 2022

Abstract
As colonial racialized subjects, Afro-Bahamian men and women were different from British subjects, and thus required a different treatment before the law. Punishment was racialized and gendered, and the discourses and resulting practices of punishment criminalized men’s and women’s bodies in distinctive ways. Evidence shows that women were as likely as men to find themselves involved with the law, and high numbers of women were arraigned by the courts and convicted of various crimes. Colonial records provide rare information about their involvement with the law, the specific nature of their crimes, and their treatment in the judicial system. Afro-Bahamian women who did not conform to society’s elite moral code were considered a threat to colonial respectability and were often found to be more intractable than men, resulting in harsh, humiliating punishments. Above all, the records demonstrate that these women exercised some form of agency, transgressing the boundaries that kept them subordinate.
Princeton Seminary’s Premature Obituary
Authors: Stewart Kenneth J. 
Published: September 2022

Abstract
It is widely granted that in the late nineteenth and early twentieth centuries, Princeton Theological Seminary had come to be recognized as an international bastion of evangelical and Reformed orthodoxy. Students, drawn to Princeton from across the USA and many points across the globe, returned home to teach and preach the Christian faith as Princeton had relayed it to them. Since the denominationally-mandated reorganization of this seminary in 1929, conservative evangelicals have circulated a narrative describing the seminary as undergoing a ‘death’ in that year. This essay seeks to show both that the theological reorientation of this seminary was much more gradual than this now-customary narrative would allow, and that the graduates of this seminary from both before and after 1929 went on exercising a wide national and international evangelical leadership for decades beyond the reorganization.
Experimental study of a heparin-coated venous stent fabricated by atomic layer deposition
Authors: Li Xiaoying , Zhang Kunpeng , Jiang Xiaorui , Wang Lei , Zhang Tao , Zhang Xiaoming , Che Haijie 
Published: September 2022

Objective To evaluate the safety and efficacy of heparin-coated venous stents in animals. Methods We used atomic layer deposition technology to obtain a heparin coating with good stability and then prepared a heparin-coated venous stent based on this technology. The experimental stents were prepared according to the diameter of the rabbit inferior vena cava and were divided into Ni-Ti alloy stent group, Ni-Ti-Al2O3 stent group and Ni-Ti-Al2O3-Heparin stent group. 3 days, 7 days and 14 days after stent implantation, the materials were collected, and the three groups of stents were observed by hard tissue section pathology, immunohistochemistry and scanning electron microscope to observe the differences in vascular wall inflammation, thrombosis, lumen stenosis and vascular intima regeneration. Result and Conclusion The experiment confirmed the safety of the heparin-coated stent in vivo. Compared with the control group, the experimental group showed a high degree of vascular endothelialization and an intact neointimal structure 14 days after implantation. The long-term safety and biological effects of heparin-coated venous stents in animals require further study.
Unpacking the relation between children’s use of digital technologies and children’s well-being: A scoping review
Authors: Messena Mattia , Everri Marina 
Published: September 2022

Over the last decade, a substantial number of studies have addressed children’s use of technologies and their impact on well-being. Nonetheless, there is still a lack of clarity on the operationalisation of technology use, well-being, and the relation between the two. This scoping review intended to shed lights on Digital Technologies Use, its operationalisation, and the relation between Digital Technologies Negative Use (DTNU) and children’s well-being. For the scope of the special issue we focused on negative use. Results showed two conceptualisations of DTNU: compulsive/addictive use of devices and the Internet (e.g., Internet addiction) and negative online experiences/risky behaviours (e.g., cyberbullying). Well-being in relation to DTNU was mainly studied in terms of psycho/social dimensions (e.g., depression), and a gap in cognitive well-being studies was identified. Study designs were largely quantitative, and, in most studies, well-being was considered as a predictor of DTNU. Also, research with children under 12 years was lacking. Future research on DTNU should look at: how dimensions of addiction and negative online experiences relate; provide more evidence on cognitive well-being; explore the interplay of well-being multiple components relying on integrative conceptual frameworks. The recent notion of digital well-being should also be explored considering the results of this review.