bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Advances in Understanding SARS-CoV-2 Infection and Updates on
Potential Diagnostic and Therapeutics for COVID-19
Authors: Mukherjee Maumita D. , Kumar Anil , Solanki Pratima R. , Verma Damini , Yadav Amit K. , Chaudhary Navneet , Kumar Pramod 
Published: March 2022

Abstract:
A more focused approach is needed to understand the SARS-CoV-2 virulence, structure, and
genomics to devise more effective diagnostic and treatment interventions as this virus can evade the immune
attack and causes life-threatening complications such as cytokine storm. The spread of the virus is
still amplifying and causing thousands of new cases worldwide. It is essential to review current diagnostics
and treatment approaches to pave the way to correct or modify our current practices to make more
effective interventions against COVID-19. COVID-19 vaccine development has moved at a breakneck
pace since the outbreak began, utilizing practically all possible platforms or tactics to ensure the success
of vaccines. A total of 42 vaccine candidates have already entered clinical trials, including promising
results from numerous vaccine candidates in phase 1 or phase 2 trials. Further, many existing drugs are
being explored on broad-spectrum antiviral medications for their use in clinical recovery against COVID-
19. The present review attempts to re-examine the SARS-CoV-2 structure, its viral life cycle, clinical
symptoms and pathogenesis, mode of transmission, diagnostics, and treatment strategies that may be useful
for resorting to more effective approaches for controlling COVID-19. Various antiviral drugs and
vaccination strategies with their strengths and weaknesses are also discussed in the paper to augment our
understanding of COVID-19 management.
María Fernanda Yasnot A. Colombia en espera de la eliminación de la malaria
Authors: Yasnot María Fernanda 
Published: March 2022

La malaria es una enfermedad que ha acompañado a los humanos desde hace más de 50.000 años, incluso puede que haya sido un patógeno humano durante toda la historia de la humanidad. De ella se tienen registros de hace unos 2700 años en la China.
Solo fue hasta 1880 que Charles Alfonse Louis Laveran obtuvo evidencias de que la malaria era producida por un protozoario. Posteriormente, Carlos Finlay sugirió que eran los mosquitos quienes la transmitían, teoría que fue corroborada por Ronald Ross en 1898 al probar que ciertas especies de mosquitos transmitían los parásitos a pájaros, al aislar parásitos de las glándulas salivales de mosquitos que se alimentaron de aves infectadas.
Los hallazgos de Finlay y Ross fueron comprobados por un comité médico dirigido por Walter Reed en 1900. Las recomendaciones derivadas de este trabajo fueron implementadas por William C. Gorgas durante la construcción del Canal de Panamá y sirvieron como base para posteriores campañas de salud pública contra la malaria.
Estratificación del riesgo de transmisión malárica en la región Caribe colombiana.
Authors: Padilla Julio Cesar , Acuña Luis Mariano , Olivera Mario Javier 
Published: March 2022

Objetivo: Determinar el riesgo de transmisión malárica en la región Caribe colombiana. Materiales y métodos: Estudio observacional de tipo descriptivo y retrospectivo en 167 municipios de la región entre los años 2010-2019. Se clasificaron los municipios como: E4: aquellos con casos autóctonos de focos activos y residuales; E3: receptivos, sin casos autóctonos, y con riesgo de importación del parásito; E2: receptivos sin transmisión y baja vulnerabilidad; E1: no receptivos ubicados por encima de los 1.600 msnm donde no existe riesgo comprobado de transmisión; acorde a la metodología de estratificación de la OPS (2019) Resultados: El 5% (8) de los municipios se clasificaron como E4, siete en el departamento de Bolívar y uno en La Guajira. El 72,4% (121) de los municipios se clasificaron E3 y el 22,8% (38) como E2. La carga acumulada de casos en la región fue de 23.285 casos, con predominio de Plasmodium vivax, y el 80,8% (18.804 casos) de la carga se registró en los municipios E4. Conclusiones: La región Caribe colombiana evidencia transmisión endemo-epidémica, focal y dispersa, variable y de muy baja intensidad. Existen dos focos de transmisión autóctona activa en el sur de Bolívar y el área rural de Riohacha, La Guajira.
Interactive Auditor-Client Negotiations: The Effects of the Accumulating Nature and Direction of Audit Differences
Authors: Hatfield Richard C. , Mullis Curtis E. , Trotman Ken T. 
Published: March 2022

ABSTRACT
In this study, we consider how the accumulating nature and income direction of audit differences influence negotiated audit adjustments. We test our expectations by constructing dyads consisting of experienced auditors and financial officers, allowing them to interact via a web-based instrument. As predicted, based on expectancy violation theory and consideration of negotiation leverage, these audit difference characteristics alter the behaviors and negotiated outcomes of our participants. Specifically, dyads determine smaller adjustments when audit differences accumulate over time. Analysis of auditor-client expectations and dialog suggests the leverage of the negotiators impacts the arguments used and the persuasiveness of those arguments. Dyads also produce smaller adjustments when an accumulating audit difference increases, rather than decreases, income, due in part to clients successfully using conservatism as a persuasive argument to convince auditors to concede. Our method provides insight into how these effects occur and how the social process can alter auditors' pre-negotiation expectations.
Efficacy and Safety of K-877 (Pemafibrate), a Selective PPARα Modulator, in European Patients on Statin Therapy
Authors: Ginsberg Henry N. , Hounslow Neil J. , Senko Yusuke , Suganami Hideki , Bogdanski Pawel , Ceska Richard , Kalina Akos , Libis Roman A. , Supryadkina Tatiana V. , Hovingh G. Kees 
Published: March 2022

OBJECTIVE
High plasma triglyceride (TG) is an independent risk factor for cardiovascular disease. Fibrates lower TG levels through peroxisome proliferator–activated receptor α (PPARα) agonism. Currently available fibrates, however, have relatively low selectivity for PPARα. The aim of this trial was to assess the safety, tolerability, and efficacy of K-877 (pemafibrate), a selective PPARα modulator, in statin-treated European patients with hypertriglyceridemia.

RESEARCH DESIGN AND METHODS
A total of 408 statin-treated adults were recruited from 68 European sites for this phase 2, randomized, double-blind, placebo-controlled trial. They had fasting TG between 175 and 500 mg/dL and HDL-cholesterol (HDL-C) ≤50 mg/dL for men and ≤55 mg/dL for women. Participants were randomly assigned to receive placebo or one of six pemafibrate regimens: 0.05 mg twice a day, 0.1 mg twice a day, 0.2 mg twice a day, 0.1 mg once daily, 0.2 mg once daily, or 0.4 mg once daily. The primary end points were TG and non–HDL-C level lowering at week 12.

RESULTS
Pemafibrate reduced TG at all doses (adjusted P value &lt;0.001), with the greatest placebo-corrected reduction from baseline to week 12 observed in the 0.2-mg twice a day treatment group (54.4%). Reductions in non–HDL-C did not reach statistical significance. Reductions in TG were associated with improvements in other markers for TG-rich lipoprotein metabolism, including reductions in apoB48, apoCIII, and remnant cholesterol and an increase in HDL-C levels. Pemafibrate increased LDL-cholesterol levels, whereas apoB100 was unchanged. Pemafibrate was safe and well-tolerated, with only minor increases in serum creatinine and homocysteine concentrations.

CONCLUSIONS
Pemafibrate is effective, safe, and well-tolerated for the reduction of TG in European populations with hypertriglyceridemia despite statin treatment.
Estimation and Economic Valuation of Above-Ground Carbon in Forest Area with the Special Purpose of Gunung Bromo, Karanganyar, Central Java, Indonesia
Authors: Rahmadwiati Rissa , Wicaksono Rezky Lasekti , Apriyanto Dwi 
Published: March 2022

Climate change and the increasing greenhouse effect are serious problems of global concern today. The existence of forests plays an essential role in carbon sequestration and storage to reduce greenhouse gas (GHG) concentration in the atmosphere. Forest Area with the Special Purpose (KHDTK) of Gunung Bromo has an area of 126,291 ha that is designated as an educational forest. The area has been managed by Universitas Sebelas Maret since 2019 and consists of three main tree species, namely Pinus merkusii, Swietenia mahagoni, and Dalbergia latifolia. This study aims to estimate the potential uptake and economic valuation of carbon stocks in the KHDTK of Gunung Bromo. Stratified Systematic Sampling with Random Start was used as an inventory method in this study. The estimation of above-ground carbon uptake used general allometric equations (non-destructive method). Furthermore, the carbon economy valuation referred to the range of calculating the average carbon price for each program specification. The results showed that the estimated carbon of tree stands in KHDTK of Gunung Bromo reached 75.81 tonnes C/ha with a carbon economic valuation of USD 758.1/ha or equivalent to IDR 10,856,863.80/ha. Exploring the potential for biodiversity (flora and fauna) and environmental services such as carbon sink will support the ecotourism program in KHDTK of Gunung Bromo.
Keywords: biomass, carbon estimation, economic valuation, KHDTK of Gunung Bromo
Workplace Violence (Mobbing) the Example of A Hospital in Greece during the Economic Crisis
Authors: Papadeli Chrysi , Filippou Adamantia , Haidemenos Ioannis , Tsilakidou Eydoksia , Krachtis Agisilaos 
Published: March 2022

Aim: During the last decade various efforts have been made to investigate and record the "mobbing syndrome" in Greece. The present study aims to map the rates of mobbing, to determine the causes, to highlight the vulnerable groups to mobbing, to describe its expression, and to document the ways of dealing with it.
Material and method: The study used the LIPT (Leymann Inventory of Psychological Terrorization) questionnaire, which has been widely used to measure mobbing. The SPSS statistical program was used for statistical analysis and processing of the results.
Results: Out of a total of 150 questionnaires, 91 were returned correctly completed. The majority of the participants were women, mainly aged 41-45 years, graduates of universities/universities of applied sciences, married, with more than 21 years of experience. The mobbing rate recorded was 16.48%. The most frequent mobbing behavior is the statement " they often talk behind your back" 31.9%, at least once a month 30% and 79% still experience mobbing behaviors to date. Mobbing of others has been observed in 45.1%. Mobbing comes from someone higher up the hierarchy in 34.1% and is attributed to the poor organization in 27.5% and management problems in 34.1%. To deal with the phenomenon they primarily turned to colleagues 29.7%.
Conclusions: This study was an attempt to investigate and document the "mobbing syndrome" among nurses in a public hospital. The results demonstrate that mobbing behaviors are practiced in the workplace and experienced by about half of the survey population and a large proportion still experience them today.
Research progress on the electrospinning nanofiber lithium-ion battery separators
Authors: Zhang Yan , Yu Bin , Zhai Mengzhen , Wang Xiaohan 
Published: March 2022

Electrospinning nanofiber membrane has the advantages of wide raw materials, large specific surface area, and high porosity. It is an ideal separator material for lithium-ion batteries. This paper first introduces two common electrospinning nanofiber diaphragms: polymer, polymer, and inorganic composite, and then focuses on the modification methods of composite modification, blending modification, and inorganic modification, as well as the methods of electrospinning nano modified polyolefin diaphragm. Finally, the development direction of the electrospinning lithium-ion battery separator has prospected.
Pemulihan Trauma Pasca Bencana pada Tokoh Anak dalam Buku Cerita Bergambar (E Hon)
Authors: Irfana En Nahl Al Atiqo Sanabila , Damayanti Silvia , Ari Sulatri Ni Luh Putu 
Published: March 2022

This study aimed to know the form of trauma recovery for child survivors after the 2011 T?hoku Tsunami, in the picture book (e hon) entitled Minna de Utau be! by Mari Mitsuoka. The method used in this research is descriptive analysis. Theories used in this research are Sigmund Freud's theory of Literature Psychology and Resilience theory by Masten (2014). The analysis results showed that child characters in e hon are described as having characteristics of mild trauma that can recover quickly through appropriate trauma recovery support. Those types of recovery support were affected by protective factors that interconnect and complement each other, such as the characteristics of child survivors, family support, and psychological support activities in the school and community environment. The effectiveness of appropriate recovery aid enhances children's resilience in the trauma recovery process, so they can recover and thrive after experiencing a natural disaster.
Informational nature of money
Authors: Kuligin V. D. 
Published: March 2022

The study of the relationship between information and money is one of the most relevant, widely discussed and yet difficult issues to explore. However, many aspects remain unclear, requiring deeper research and understanding. The object of this study was the nature of subjective assessments, their qualitative and quantitative characteristics in relation to the direct exchange of things. The content of objective exchange value as a relative value that is not measurable has been revealed in the article. It carries with it information about the proportion of things exchanged. The quantitative ratio of the value of the available monetary units and the units value of goods exchanged for them determines the price of money. The connection between commodity and credit money has been traced. It has been proved that money fulfills its information function as imaginary, ideal money. It has been concluded about the spontaneous adaptation of the competitive markets, money and prices information system to the conditions of falling purchasing power of money. The results of the study extend knowledge about the informational nature of money and outline perspectives for further research.
Administrative offenses cases number assessment in the Russian regions
Authors: Belyaeva D. I. , Davletshina L. A. 
Published: March 2022

Reducing crime is an important objective in the Russian Federation, therefore monitoring the dynamics of offending is relevant and of research interest nowadays. The aim of the article is to analyse the number of administrative offenses cases initiated by officials in the regions of the Russian Federation, as well as the changes that have occurred in the period between 2006 and 2019. In order to obtain a stable classification, all regions of Russia were ranked according to the arithmetic average number of administrative offenses cases for the period indicated. The paper implemented the cluster analysis method to identify typical, similar regions in terms of administrative offenses. The clusters and atypical regions composition according to the number of administrative offenses cases in the Russian Federation for the analysed period was formed. The deviations of the clusters and regions values from the average Russian level were calculated.
DIVULGAÇÃO CIENTÍFICA DOS CENTROS DE PESQUISA, INOVAÇÃO E DIFUSÃO (CEPIDS) DA FAPESP
Authors: Maluly Luciano Victor Barros , Teixeira Carlos Antonio 
Published: March 2022

Este artigo apresenta os resultados de um projeto de pesquisa jornalística vinculado ao Programa José Reis de Incentivo ao Jornalismo Científico (Mídia Ciência) da Fundação de Amparo à Ciência do Estado de São Paulo (FAPESP). A proposta viabilizou a produção de 24 programas de rádio para divulgação científica dos Centros de Pesquisa, Inovação e Difusão (CEPIDs), que foram disponibilizados no repositório de Radiojornalismo do Departamento de Jornalismo e Editoração da Escola de Comunicações e Artes da Universidade de São Paulo, com os principais sendo transmitidos pela Rádio USP. A análise e construção dos programas teve, como referência, o método Cassete-Foro, proposto por Mario Kaplún, justamente por possibilitar a integração entre atores do processo (professores e alunos de Escolas Públicas, pesquisador e mediador) e, ao mesmo tempo, disponibilizar o material gravado para realimentação e/ou troca de informações. O principal objetivo do projeto foi o de incentivar jovens estudantes a se interessarem pelas carreiras científicas.
Nem tudo que reluz é ouro: discutindo memes e fake news em tempos de pandemia
Authors: Teixeira Marcelle Medeiros , Couto Junior Dilton Ribeiro , Brito Leandro Teofilo de 
Published: March 2022

Este texto, fruto de pesquisa de mestrado em andamento, visa discutir o papel dos memes em resposta às fake newsbrasileiras compartilhadas na rede em tempos de pandemia. O trabalho selecionou memes que evidenciam alguns episódios brasileiros recentes que trazem à tona temas como a banalização do novo coronavírus, possíveis tratamentos para a cura da doença, além de uma crescente insatisfação social na rede diante da forma pela qual o Governo Federal vem lidando com a pandemia no país. Para isso, apostamos na abordagem cartográfica para refletir sobre o que narram os memes postados na rede em tempos de pandemia, reconhecendo que esses arquivos digitais nos convidam a olhar criticamente para as repercussões sociais de um tempo marcado por intensas disputas políticas. Pesquisar memes que expõem fake news brasileiras significa apostar na importância da rede para potencializar a produção e o compartilhamento de imagens-dizeres que nos convidam a participar de um importante movimento ciberativista orquestrado na internet contra algumas decisões governamentais em tempos de pandemia.
Illegal domestic tourism of Poles during the COVID-19 pandemic – introduction to the research
Authors: Kugiejko Magdalena , Żyto Artur 
Published: March 2022

Motives: Tourism is one of the most affected industries by the COVID-19 pandemic. The restrictions introduced by the Polish government, dictated by the rapidly increasing number of positive cases in the country, led to severe restrictions or complete cessation of the accommodation, catering and tourist services. These restrictions resulted in greater interest in the “little homeland” tourist offer, the dispersion of tourist traffic and the development of so called “grey zone” through unofficial functioning of accommodation facilities.Aim: The purpose of this paper is to characterize the profile of tourists who paid for the accommodation services in Poland during the second wave of the pandemic, lasting from 7th November 2020 to 11th February 2021. The research methodology included a diagnostic survey conducted through the use of a digital questionnaire circulated in social media. In total 100 responses were subjected to qualitative analysis. On the basis of the obtained results, the authors analyzed the following criteria: the number, time, place, length and method of organization of trips; type of accommodation with the costs estimate and the method of obtaining information about the functioning of the chosen facility; means of transportation to the destination, main and secondary travel motives. The study also presents the changes declared by the respondents in the frequency of organizing a one-day trip and several-day-long trips away from the place of their daily residence, as well as the assessment of the quality of the services provided against the price.Results: Almost 70% of the respondents paid for the accommodation services in the given time frame at least once, mainly booking private lodging using Booking.com portal. The organized trips were usually short-term and lasted 3 days. Only every 5th trip was planned in advance, before the restrictions were introduced. The main motive for the trip was the desire to change the environment,understood as escaping the city and relaxing outdoors. The vast majority of respondents did not suffer from COVID-19 before the trip, and every fourth respondent considered the applicable restrictions as too severe.
PENGARUH KEPEMIMPINAN KEPALA SEKOLAH DAN KOMUNIKASI ORGANISASI SEKOLAH TERHADAP KOMPETENSI GURU DAN DAMPAKNYA TERHADAP KUALITAS PEMBELAJARAN
Authors: Hermansyah Aan 
Published: March 2022

This study aims to determine: 1) The leadership of the school principal, organizational communication, teacher competencies, and the quality of learning. 2) The influence of the principal's leadership on the competence of teachers, 3) The effect of organizational communication on the competence of teachers, 4) The influence of school principlas leadership and organizational communication together on the competence, and 5) the effect of teacher competence on the quality of learning in state high schools in Majalengka Regency. This research method is a quantitative research method with descriptive and verification analysis techniques. Descriptive method using the calculation of frequency distribution, scoring and average value, while the verification method using path analysis. The sampling technique was taken by cluster proportional random sampling. Descriptive research results indicate that the principal's leadership, organizational communication, teacher competence and learning quality are in the good category. The results of the verification study prove that leadership and organizational communication have a positive and significant effect on teacher competency either partially or simultaneously. Teacher competence has a positive and significant effect on the quality of learning
PENGARUH SUPERVISI KEPALA SEKOLAH DAN PENGAWAS TERHADAP KREATIVITAS GURU SERTA DAMPAKNYA TERHADAP PRESTASI SEKOLAH
Authors: Ali Mohamad 
Published: March 2022

This study aims to determine: 1) Supervision of high school principals; 2) Supervision of high school supervisors; 3) The creativity of high school teachers; 4) Student achievement; 5) the effect of supervision by high school principals on teacher creativity; 6) the effect of supervision of high school supervisors on the creativity of teachers; 7) the influence of supervision of high school principals and high school supervisors on the creativity of teachers; 8) The effect of the creativity of high school teachers on school performance in Majalengka Regency. This research method is a quantitative research method with descriptive and verification analysis techniques. Descriptive method using the calculation of frequency distribution, scoring and average value, while the verification method using path analysis. The sampling technique was taken by cluster proportional random sampling. Descriptive research results indicate that supervision carried out by principals and school supervisors is in the quite good category, while creativity and student achievement are in the quite up to good category. The results of the study verify that the supervision conducted by the school principal and school supervisor has a positive and significant effect on the teacher's creativity either partially or simultaneously. Teacher creativity has a positive and significant effect on student achievement