bluuebunny/crossref_metadata_2025_split huggingface dataset:
Motivation, perceived authenticity and satisfaction of tourists visiting the monastery of Mor Hananyo-Mardin, Turkey
Authors: Seyitoğlu Faruk , Çakar Kadir , Davras Özgür 
Published: May 2022

Purpose
This study aims to investigate the relationship between the dimensions of motivation, perceived authenticity and satisfaction of tourists visiting the Mor Hananyo Monastery as a heritage site.

Design/methodology/approach
The quantitative research method was implemented to test the proposed structural model. Accordingly, a self-administered questionnaire was applied to 341 tourists visiting the monastery of Mor Hananyo between April and May 2019. First, confirmatory factor analysis was performed to ensure the scales’ construct validity; then, the covariance-based structural equation model was established to test the research hypothesis with the help of path analysis.

Findings
The results showed that all motivation dimensions influence the objective authenticity perception of tourists. Heritage and ancestral motivations influence the constructive authenticity perception of tourists. However, the effect of educational motivation on the same variable was insignificant. Furthermore, only heritage motivation affects the existential authenticity perception of tourists.

Originality/value
The results of this study demonstrate that tourist satisfaction has causal relationships with travel motivations and authenticity perceptions. Additionally, although tourist satisfaction has been accepted as an essential and extensively discussed subject in the tourism literature, this study is the first to examine the structural relationships of travel motivations (ancestral, heritage and educational motivations), authenticity perceptions (objective, constructive and existential authenticity) and tourist satisfaction in the monastery context.
Research-informed teaching for assessing BIM courses during COVID-19 and beyond
Authors: Abanda Fonbeyin Henry 
Published: May 2022

PurposeIn the COVID-19 era, where blended learning is gaining popularity, research-informed teaching could be one of the alternatives or options to assess students' progress in Higher Education institutions. In the past, educators have assessed students' research skills gained from research-informed teaching through coursework components or assignments. However, whether the assignments can be converted into peer-reviewed output acceptable in a reputable journal or conference has hardly been investigated. This study explores how research-informed teaching has been rolled out in undergraduate/postgraduate BIM related modules/programmes in the School of the Built Environment, Oxford Brookes University and which has culminated in high quality published outputs.Design/methodology/approachThe method used is purely qualitative in-depth interviews, where students who have published were tracked and invited to share their experiences. In total, nine former students of the 12 invited, participated in the interviews. Inductive content analysis, a suitable qualitative data analysis technique was used in analysing the feedback from the interviews.FindingsThe main finding is that research-informed teaching can be done in a technical and complex BIM discipline and students' coursework components or assignments can further be converted into published outputs.Research limitations/implicationsThe main limitation of this study was that the sample was small. That notwithstanding, it has provided valuable insights into the understanding of student's ability to undertake research while studying and experiences of how educators can deliver research-informed teaching to students in Higher Education institutions.Originality/valueThe study adds to the existing body of literature about undergraduate and postgraduate research-informed teaching and goes further to provide strong evidence through published outputs thereby confirming that students at both levels can indeed conduct and publish peer-reviewed research articles while undertaking their studies.
Effects of demographic factors on women’s participation in the Islamic microfinance scheme: an analysis using the theory of bounded rationality
Authors: Ashraf Mohammad Ali 
Published: May 2022

Purpose
The purpose of this paper is to identify the factors that influence the individual bounded rationality of the rural poor toward participation in borrowing from rural development scheme (RDS). Specifically, how do respondents’ demographic variables such as gender, age, education, income and religion affect their attitude, subjective norms (SNs) and perceived behavioral control (PBC) to influence bounded rationality toward actual participation in borrowing the Islamic funds from RDS?

Design/methodology/approach
To answer these questions, the theory of bounded rational planned behavior as its basis was established. Data (n = 375) were collected from rural women clients of RDS based on snow-balling sampling technique. Data were analyzed following the procedure of structural equation modeling.

Findings
The results indicate that all the demographic variables except education influence attitudes, SNs and PBC in turn influence the individual respondents’ bounded rational intention toward participation in RDS.

Research limitations/implications
The sample was not randomly drawn to represent a population to which findings could be generalized. Instead, it was a snow-balling sample, and as such, the ability to generalize the findings very far beyond the sample is limited.

Practical implications
This paper implies that respondents’ socioeconomic characteristics are important to consider changing individual subjective rationality of human being toward performing actual behavior.

Social implications
Social implications refer that rural women in Bangladesh are positively and subjectively motivated toward bounded rational intention and participation in RDS.

Originality/value
This research is based on the primary data collected from the participants in an Islamic microfinance institute called RDS. This paper draws on several insights about the participation behavior of the rural poor in Bangladesh.
Tree species with conservative foliar nutrient status and strong phosphorus homeostasis are regionally abundant in subtropical forests
Authors: Ci Hang , Guo Chao , Tuo Bin , Zheng Li‐Ting , Xu Ming‐Shan , Sai Bi‐Le , Yang Bai‐Yu , Yang Yong‐Chuan , You Wen‐Hui , Yan En‐Rong , Cornelissen Johannes H. C. 
Published: May 2022

Abstract

Foliar nitrogen (N) or phosphorus (P) status and their stoichiometric homeostasis are integral parts of the plant nutrient economy that determines the success of plant species in environments where N or P limits plant growth. Despite growing evidence for higher predictability of stoichiometric homeostasis of N (HN) than that of P (HP) on plant species abundance in temperate grasslands, no previous studies explicitly examined how foliar N and P status modulate the relationships between stoichiometric homeostasis and species distribution (regional species abundance) of woody plants, especially in P‐limited (sub)tropical ecosystems. We hypothesized that species with a conservative foliar nutrient status but a higher HP (but not HN) would be regional abundant in P‐limited forest.

We measured foliar N (LNC) and P (LPC) contents of 54 woody species, community composition and soil N and P contents across 94 forest plots in Chinese subtropical forests. Then we evaluated the species' levels of N and P stoichiometric homeostasis and their regional abundance to test our hypotheses.

HN and HP significantly increased with decreasing LNC and LPC. Foliar nutrient status positively correlated with the minimum values of both soil N and P contents, but only negatively associated with the maximum value of soil P content, indicating that conservative species can occupy a wider range of soil P‐ than N‐based nutrient niche. Meanwhile, species abundance negatively correlated with LNC and LPC, and positively correlated with HN and HP. However, the structure equation model analysis showed that species abundance increased with decline of LNC but not yet with increased HN. In contrast, species abundance enhanced with increased HP and decreased LPC via HP, rather than directly with a decline of LPC.

Synthesis. This study provides empirical evidence that species with conservative foliar nutrient status are more stable in terms of N and P stoichiometric homeostasis, and foliar N and P economy modulate species abundance distribution in different ways. Our results suggest that maintaining strong stoichiometric homeostasis of leaf P, while maintaining conservative economy of N, is a key physiochemical mechanism for shaping species abundance distribution in P‐limited forests.
A Bayesian Functional Data Model for Surveys Collected under Informative Sampling with Application to Mortality Estimation Using NHANES
Authors: Parker Paul A. , Holan Scott H. 
Published: May 2022

Abstract
Functional data are often extremely high-dimensional and exhibit strong dependence structures but can often prove valuable for both prediction and inference. The literature on functional data analysis is well developed; however, there has been very little work involving functional data in complex survey settings. Motivated by physical activity monitor data from the National Health and Nutrition Examination Survey (NHANES), we develop a Bayesian model for functional covariates that can properly account for the survey design. Our approach is intended for non-Gaussian data and can be applied in multivariate settings. In addition, we make use of a variety of Bayesian modeling techniques to ensure that the model is fit in a computationally efficient manner. We illustrate the value of our approach through two simulation studies as well as an example of mortality estimation using NHANES data.
IFN‐α/β‐mediated NK2R expression is related to the malignancy of colon cancer cells
Authors: Xiang Huihui , Toyoshima Yujiro , Shen Weidong , Wang Xiangdong , Okada Naoki , Kii Shuhei , Sugiyama Ko , Nagato Toshihiro , Kobayashi Hiroya , Ikeo Kazuho , Hashimoto Shinichi , Tanino Mishie , Taketomi Akinobu , Kitamura Hidemitsu 
Published: May 2022

AbstractNeurokinin 2 receptor (NK2R), a G protein‐coupled receptor for neurokinin A (NKA), a tachykinin family member, regulates various physiological functions including pain response, relaxation of smooth muscle, dilation of blood vessels, and vascular permeability. However, the precise role and regulation of NK2R expression in cancer cells have not been fully elucidated. In this study, we found that high NK2R gene expression was correlated with the poor survival of colorectal cancer patients, and Interferon (IFN‐α/β) stimulation significantly enhanced NK2R gene expression level of colon cancer cells in a Janus kinas 1/2 (JAK 1/2)‐dependent manner. NKA stimulation augmented viability/proliferation and phosphorylation of Extracellular‐signal‐regulated kinase 1/2 (ERK1/2) levels of IFN‐α/β‐treated colon cancer cells and NK2R blockade by using a selective antagonist reduced the proliferation in vitro. Administration of an NK2R antagonist alone or combined with polyinosinic‐polycytidylic acid, a synthetic analog of double‐stranded RNA, to CT26‐bearing mice significantly suppressed tumorigenesis. NK2R‐overexpressing CT26 cells showed enhanced tumorigenesis and metastatic colonization in both lung and liver after the inoculation into mice. These findings indicate that IFN‐α/β‐mediated NK2R expression is related to the malignancy of colon cancer cells, suggesting that NK2R blockade may be a promising strategy for colon cancers.
Building a space to dream: Supporting indigenous children's survivance through community‐engaged social and emotional learning
Authors: Sun Jingjing , Goforth Anisa N. , Nichols Lindsey M. , Violante Amy , Christopher Kelsey , Howlett Ronda , Hogenson Debbie , Graham Niki 
Published: May 2022

AbstractIndigenous communities practice survivance and challenge social and political systems to support their children's identity and well‐being. Grounded in transformative social‐emotional learning (SEL) and tribal critical race theory, this 3‐year community‐based participatory research study (2019–2021) examined how a SEL program co‐created with an Indigenous community in Flathead Nation in Montana supports anti‐racism and anti‐colonialism among Indigenous children. Critical reflexivity and thematic analyses of Community Advisory Board meetings and journals written by 60 students (Mage = 10.3, SD = 1.45; 47% girls; 60% Native American) during the SEL program revealed themes on Indigenous identity, belonging, wellness, and colonialism. These results shed light on challenging the racist and colonial roots of education to support Indigenous children's survivance and social‐emotional well‐being.
Single‐cell sequencing reveals the heterogeneity and intratumoral crosstalk in human endometrial cancer
Authors: Yu Zhicheng , Zhang Jun , Zhang Qi , Wei Sitian , Shi Rui , Zhao Rong , An Lanfen , Grose Richard , Feng Dilu , Wang Hongbo 
Published: May 2022

AbstractBackgroundEndometrial cancer (EC) is one of the most common gynecologic malignancies with increasing morbidity. Cell–cell and cell‐matrix interactions within the tumour microenvironment (TME) exert a powerful influence over the progression of EC. Therefore, a comprehensive exploration of heterogeneity and intratumoral crosstalk is essential to elucidate the mechanisms driving EC progression and develop novel therapeutic approaches.Methods4 EC and 2 normal endometrium samples were applied for single‐cell RNA sequencing (scRNA‐seq) analysis. In addition, we also included the public database to explore the clinical benefits of the single cell analysis.Results9 types of cells were identified with specific expression of maker genes. Both the malignant epithelial cells and cells comprising the immune microenvironment displayed a high degree of intertumoral heterogeneity. Notably, the proliferation T cells also showed an exhausted feature. Moreover, the malignant cells may induce an immunosuppressive microenvironment through TNF‐ICOS pair. Cancer‐associated fibroblasts (CAFs) were divided into four subsets with distinct characteristics and they maintained frequent communications with malignant cells which facilitating the progression of EC. We also found that the existence of vascular CAF (vCAF) may indicate a worse prognosis for EC patients through integrating TCGA database.ConclusionThe TME of human EC remains highly heterogeneous. Out finding that malignant cells interact closely with immune cells and vCAFs identifies potential therapeutic targets.
Movement of nest‐searching bumblebee queens reflects nesting habitat quality
Authors: Pugesek Genevieve , Crone Elizabeth E. 
Published: May 2022

Abstract
Movement of foraging animals can be used as an indirect index of habitat quality because movement patterns are expected to shift in association with resources resulting in increased time spent in high‐quality habitat. Here, we observed movement of bumblebee (Bombus impatiens) queens as an indirect metric of nesting habitat quality.
At a farm in Massachusetts, we recorded flight paths by visual observation of nest‐searching B. impatiens queens in three land cover types (hay fields, meadows and forests). According to previous research at this field site, these land cover types represent both high‐quality (meadows, forests) and low‐quality habitat (hay fields) for nesting bumblebees. Using flight path data, we estimated diffusion coefficients of nest‐searching queens (i.e., the rate at which queens explore habitat during nest‐searching), as an integrative measure of movement.
We found that nest‐searching queens explored meadows and forests more slowly than hay fields; we calculated diffusion coefficients of 0.198, 0.272, and 0.762 m2 s−1 for bees searching for nests in meadows, forests, and hay fields, respectively. In hay fields, nest‐searching queens had smaller step lengths and straighter flightpaths than in other land cover types.
Nesting ecology of bumblebees is a key knowledge gap. We showed that nest‐searching queens search more thoroughly in areas associated with previously reported high nest densities. Therefore, our research suggests that behaviour of nest‐searching queens can also be a proxy for nesting habitat quality. Extending these methods to other Bombus species in other landscapes would be a valuable direction for future research.
LongHest project: A prospective, observational study of extended half‐life treatment in the musculoskeletal health of patients with severe haemophilia A
Authors: Cuesta‐Barriuso Rubén , Pérez‐Llanes Raúl , Donoso‐Úbeda Elena , Ucero‐Lozano Roberto 
Published: May 2022

AbstractBackgroundProphylactic treatment is the gold standard in the treatment of patients with haemophilia. Prophylaxis with extended half‐life (EHL) treatment has shown long‐term safety and efficacy in patients with haemophilia.AimTo evaluate the efficacy of prophylaxis with EHL treatment in the frequency of haemarthrosis and musculoskeletal health in adult patients with severe haemophilia A.MethodsProspective cohort study. Forty‐six patients with severe haemophilia A were recruited. The frequency of haemarthrosis (self‐reports), joint condition (Haemophilia Joint Health Score), pain intensity (visual analogue scale), range of motion (goniometry), and strength (dynamometry) and muscle activation (surface electromyography) were evaluated. Three assessments were carried out: at baseline (T0), at 6 months (T1) and at 12 months following treatment (T2).ResultsThere were significant changes in the within‐subject effect in the frequency of haemarthrosis in elbow (F(1.05;96.20) = 3.95; P < .001) and knee (F(1.73;157.99) = 9.96; P < .001). Significant within‐subject effect in elbow pain intensity (F(2;182) = 63.51; P < .001) was found. The mean values of the frequency haemarthrosis in elbow (from .66±1.01 to .04±.20) and knees (from .55±.68 to .33±.53) decrease after the period study. The intensity of elbow pain and (from 3.08±1.69 to 2.67±1.73), decrease after the 12‐month follow‐up period.ConclusionsProphylaxis with extended half‐life treatment reduces the frequency of haemarthrosis in elbow and knee in adult patients with haemophilia. EHL treatment reduces the intensity of elbow pain in patients with haemophilic arthropathy.
Characterisation, rheological properties and immunomodulatory efficiency of corn silk polysaccharides
Authors: Abdin Mohamed , El‐Beltagy Alaa El‐Dein , Naeem Mohamed Ahmed 
Published: May 2022

SummaryCorn silk polysaccharide (CSP) was isolated by heated 80 °C ethanol 70%. The extracted light (83.70 L*) with a yellowish (13.09 b*) reddish (1.98 a*) CSP had an ash content of 2.53 ± 0.03%. It is mainly composed of seven monosaccharides (xylose 23.64, glucose 16.65, ribose 17.35, galactose 13.64, rhamnose 11.93, arabinose 11.87 and mannose 4.85 mol%) and showed four peaks in 13C NMR correlated to the anomeric carbon of arabinose and/or xylose residues. The thermal characteristics exhibited the breakdown of CSP glycosidic bonds at 321.16 °C. The rheological properties showed that the raising of share rate (γ) caused a reduction in apparent viscosity for all tested concentrations, whilst the elastic G′ and viscous G″ storage moduli of CSP were enhanced by increasing the oscillation frequency. The immunomodulatory effects of CSP on RAW264.7 cells showed a significant (P < 0.05) increase in NO secretion up to a concentration of 80 μg mL−1 from CSP. Additionally, the phagocytosis index and acid phosphatase activity were enhanced (P < 0.05) in a dose‐dependent manner by increasing CSP concentrations.
Differential distribution of vitamin D receptor (VDR) gene variants and its expression in systemic lupus erythematosus
Authors: De Azevêdo Silva Jaqueline , de Lima Suelen Cristina , Fragoso Thiago Sotero , Cavalcanti Catarina Addobbati Jordão , Barbosa Alexandre Domingues , Borborema Maria Eduarda de Albuquerque , de Lucena Thays Maria Costa , Duarte Angela Luzia Branco Pinto , Crovella Sergio , Sandrin‐Garcia Paula 
Published: May 2022

AbstractSystemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder that displays an important genetic background. Vitamin D3 (VD3) through its receptor (VDR) plays an important immunomodulatory role in autoimmune misbalance, being capable of modulating immune responses. Genetic alterations in VDR gene may contribute to an altered risk in SLE development and clinical manifestations. We investigated VDR SNPs (single nucleotide polymorphisms) frequencies in 128 SLE patients and 138 healthy controls (HC) and mRNA differential expression in 29 patients and 17 HC regarding SLE susceptibility as well as clinical features. We observed that rs11168268 G allele (OR = 1.55, p = .01) and G/G genotype (OR = 2.69, p = .008) were associated with increased SLE susceptibility. The rs2248098 G allele and A/G and G/G genotypes were associated to lower SLE susceptibility (OR = 0.66, p = .01; OR = 0.46, p = .01; OR = 0.44, p = .02, respectively). Regarding clinical features, we observed lower risk for: rs11168268 A/G genotype and nephritis (OR = 0.31, p = .01); rs4760648 T/T genotype and photosensitivity (OR = 0.24, p = .02); rs1540339 T/T genotype and antibody anti‐dsDNA (OR = 0.19, p = .015); rs3890733 T/T genotype and serositis (OR = 0.10, p = .01). We identified a significant downregulation in VDR expression levels when compared patients and controls overall (p = 1.04e–7), in Cdx‐2 A/G and G/G (p = .008 and p = .014, respectively) and in patients with nephritis (p = .016)Our results suggested that VDR SNPs influence upon SLE susceptibility and in particular clinical features, acting on mRNA expression in SLE patients overall and the ones with nephritis.
Crystal structure and luminescence mechanism of novel Fe3+‐doped Mg0.752Al2.165O4 deep red‐emitting phosphors
Authors: Qi Fei , Tu Guangsheng , Tu Bingtian , Wang Hao , Zhang Jian , Wang Weimin , Fu Zhengyi 
Published: May 2022

AbstractNonstoichiometric alumina‐rich spinel provides diverse and changeable local environments for transition‐metal dopants. In this contribution, novel Mg0.752Al2.165−xO4:xFe3+ deep red‐emitting phosphors were designed and prepared by the solid‐state reaction method. The red emission presents an unexpected shift from 735 to 770 nm by comparing with Fe3+‐doped MgAl2O4. The excitation spectrum of Mg0.752Al2.165−xO4:xFe3+ is broadened in the UV region with a new strong peak at 320 nm. The crystal structure refinement and NMR spectra fitting reveal that the cation vacancies and disorder increase with excess Al3+ entering the spinel crystal lattice. According to the results of EPR, NMR, and PL/PLE measurements, it was proposed that the Fe3+ ions locate at the distorted octahedral coordination. The changes of the local structure of Fe3+ ions promote the doublet state's involvement in the d−d transition. It was proposed that the new excitation peak at 320 nm in Mg0.752Al2.165−xO4:xFe3+ is associated with the transitions from the ground state 6A1g(6S) to the 4A2g(4F)/T1g(4P) and doublet states. The transition between the lower energy excited state of 2T2g(2I) and 6A1g(6S) mainly contributes to the deep red emission and the red‐shifting effect.