bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of flywheel resistance training on the running economy of young male well-trained distance runners
Authors: Weng Yingying , Liu Haochong , Ruan Tingting , Yang Wenpu , Wei Hongwen , Cui Yixiong , Ho Indy Man Kit , Li Qian 
Published: December 2022

The study aimed to investigate the effect of flywheel accentuated eccentric loading (AEL) training on the running economy (RE) of young male well-trained distance runners. Twenty-two runners participated and were randomly assigned to the flywheel (FG, n = 12) and the control group (CG, n = 10). Traditional endurance training was performed in both groups three times a week for 6-week, while traditional resistance and flywheel AEL training was added to the CG and FG respectively. Subjects performed the incremental exercise test, squat jump, and countermovement jump (CMJ) before and after training. The results showed that 1) the RE at 65% of peak oxygen consumption (VO2peak), 75% VO2peak, and 85% VO2peak improved significantly after 6 weeks of training (p &lt; 0.01, Effect size (ES) = 0.76; p &lt; 0.01, ES = 1.04; p &lt; 0.01, ES = 1.85) in FG, and the RE of 85% VO2peak in FG was significantly lower than CG (p &lt; 0.05, ES = 0.30); 2) in post-training, both squat jump (p &lt; 0.01, ES = 0.73) and CMJ (p &lt; 0.01, ES = 1.15) performance, eccentric utilization ratio (p &lt; 0.04, ES = 0.44), the rate of force development (RFD) of squat jump (p &lt; 0.05, ES = 0.46), and CMJRFD (p &lt; 0.01, ES = 0.66) were significantly improved in FG. And there are no significant differents in CG group because it was maintain training for our participants. Our findings showed that 1) flywheel AEL training improves the muscles’ explosive strength and other neuromuscular functions, and improves the athlete’s running economy under 65%, 75%, and 85% VO2peak, which potentially increases endurance performance. 2) Flywheel AEL training can improve the height, RFD, and the eccentric utilization ratio of squat jump and CMJ, and other lower limb elastic potential energy indicators of the young male, well-trained distance runners.
Overexpression of MsSAG113 gene promotes leaf senescence in alfalfa via participating in the hormone regulatory network
Authors: Li Shuwen , Xie Hong , Zhou Lingfang , Dong Di , Liu Yaling , Jia Chenyan , Han Liebao , Chao Yuehui , Chen Yinglong 
Published: December 2022

IntroductionAlfalfa (Medicago sativa) is a kind of high quality leguminous forage species, which was widely cultivated in the world. Leaf senescence is an essential process in plant development and life cycle. Here, we reported the isolation and functional analysis of an alfalfa SENESCENCE-ASSOCIATED GENE113 (MsSAG113), which belongs to the PP2C family and mainly plays a role in promoting plant senescence.MethodsIn the study, Agrobacterium-mediated, gene expression analysis, next generation sequencing, DNA pull-down, yeast single hybridization and transient expression were used to identify the function of MsSAG113 gene.ResultsThe MsSAG113 gene was isolated from alfalfa, and the transgenic plants were obtained by Agrobacterium-mediated method. Compared with the wildtype, transgenic plants showed premature senescence in leaves, especially when cultivated under dark conditions. Meanwhile, application of exogenous hormones ABA, SA, MeJA, obviously acclerated leaf senescence of transgenic plants. Furthermore, the detached leaves from transgenic plants turned yellow earlier with lower chlorophyll content. Transcriptome analysis identified a total of 1,392 differentially expressed genes (DEGs), involving 13 transcription factor families. Of which, 234 genes were related to phytohormone synthesis, metabolism and transduction. Pull-down assay and yeast one-hybrid assay confirmed that alfalfa zinc finger CCCH domain-containing protein 39 (MsC3H-39) could directly bind the upstream of MsSAG113 gene. In conclusion, the MsSAG113 gene plays a crucial role in promoting leaf senescence in alfalfa via participating in the hormone regulatory network.DiscussionThis provides an essential basis for further analysis on the regulatory network involving senescence-associated genes in alfalfa.
Soiltesting formula fertilization with organic fertilizer addition for target yield cannot stand long due to stem lodging of rice
Authors: Zhao Fucheng , Li Fan , Zhou Juan , Sun Xiaolin , Wang Yun , Jing Liquan , Hou Junfeng , Bao Fei , Wang Guiyue , Chen Bin 
Published: December 2022

IntroductionSoil testing formula fertilization using organic fertilizer (STFFOF)could increase grain yields and protect the ecological environment but the potential risks of STFFOF remains unclear.MethodsIn order to assess the risk on rice stem lodging, a STFFOF field experiment is conducted continuously for 11 years.ResultsAfter 11 years of continuous STFFOF treatment, the stem lodging rate of rice substantially increases by 81.1%*, which completely overweigh its increase in yield. Further research found that STFFOF greatly decreases the concentration of Ca, SiO2, K, Mg, and non-structural carbohydrates in basal internodes, dramatically increases that of N, P, and weight per ear, but slightly affects the structural carbohydrates. The strong correlations imply the increasement in weight per ear, N, and P concentrations, and the significant decrease in starch in the basal internodes might directly increase the brittleness of stem internodes and further cause severe stem lodging and yield loss of rice.DiscussionResults suggest that the potential risks of rice production including stem lodging must be considered when adopting the excessive exploration mode of productivity technology of paddy fields.
The chain-mediation pathway of gender regarding academic delay of gratification in college students is regulated by anxiety/depressive mood and prospective memory
Authors: Jiao Chen-Yang , Song Xun , Shao Wen-Yi , Feng Lin-Pu , Jiao Dong-Liang 
Published: December 2022

ObjectiveThis study investigated the relationship between gender and academic delay of gratification (ADOG) in college students and explored the mediating roles of anxiety/depressive mood and prospective memory to provide a theoretical intervention approach based on internal mechanisms.MethodsRandom cluster sampling was conducted on 609 students from three universities situated in the Province of Anhui, China with the use of data from several questionnaires: the general information questionnaire, Generalized Anxiety Disorder Scale, Patient Health Questionnaire, Prospective and Retrospective Memory (PRM) Questionnaire, and ADOG Scale.ResultsThe females’ anxiety and depression levels were lower than that of the males, while the female PRM and ADOG performance improved when compared to that of the males. Anxiety and depression were negatively correlated with PRM and ADOG, respectively, whereas the PRM and ADOG data demonstrated a positive correlation. Depression/anxiety and prospective memory also played a chain intermediary role between gender and ADOG.ConclusionGender not only directly affects college students’ ADOG, but it also has indirect effects through depression/anxiety and prospective memory. Therefore, it is very important to treat students’ mental health differently according to gender to improve prospective memory and delayed academic satisfaction.
Role of emotion regulation capacities in affective state among Chinese high school students in the post-pandemic era of COVID-19
Authors: Wang Suyan , Chu Yuying , Dai Hongliang 
Published: December 2022

ObjectivePsychological wellbeing and emotion regulation skills of vulnerable adolescents have been severely threatened by the long-term impact of the ongoing COVID-19 pandemic. The aim of this study was to seek out the potentially effective emotion regulation strategies to minimize the mental health risk of adolescents during the COVID-19 post-pandemic era.MethodsA total of 436 high school students aged 16.07 ± 1.08 years were included in this cross-sectional study to complete questionnaires to self-report socio-demographic information, positive and negative affect state, and emotional regulation abilities. Student'st-test and one-way analysis of variance (ANOVA) were used for intergroup comparisons among socio-demographic variables. Pearson's correlation analysis was used for evaluating the association between each emotion regulation strategy and positivity or negativity. Multiple stepwise linear regression analysis was used for the determination of the predictors for adolescents' positivity and negativity.ResultsAdolescents' affect was influenced by multiple emotion regulation strategies, including cognitive reappraisal, acceptance and engagement, difficulty in awareness, acceptance, and modification of emotions after adjusting for a range of socio-demographic variables.ConclusionOverall, our findings highlight the importance of emotional regulation strategies in the modulation of the mental health of the vulnerable youth population in China during the COVID-19 crisis. In view of the continuous, multifaceted influence on adolescents' mental health of the ongoing pandemic, more effort should be made to leverage emotion regulation strategies to benefit their coping abilities.
Physician challenges and supports during the first wave of the COVID-19 pandemic: A mixed methods study
Authors: Williams Myia S. , Ryniker Laura , Schwartz Rebecca M. , Shaam Pooja , Finuf Kayla D. , Corley Samantha S. , Parashar Nidhi , Young John Q. , Bellehsen Mayer H. , Jan Sophia 
Published: December 2022

IntroductionDuring the COVID-19 pandemic, physicians encountered significant COVID-19-related negative experiences and psychological distress in both their personal and professional lives. To understand the factors that negatively impact physician well-being, a number of studies have pointed to multiple work system factors such as excessive workload and workflow interruptions. In addition, studies have shown that positive interpersonal relationships that provide social support may also serve as a buffering role against psychological distress. The aim of our study explores the challenges and sources of support for physicians relative to mental health symptoms.MethodsIn this study, We used a cross-sectional study design with a convergent parallel mixed method approach combining both qualitative and quantitative data collected in parallel from a self-report questionnaire immediately following the first wave of COVID-19. The aim of our study explores the challenges and sources of support for physicians relative to mental health symptoms.ResultsOf the 457 physicians in the study, the most frequently potential negative occupational experiences were, “Being at risk of contracting COVID-19 from patients/co-workers” (90.5%) and “Contact with distressed family members who cannot be with a loved one” (69.5%). We identified five common themes for main sources of social support (e.g. emotional support from family/friends) and six themes for challenges (e.g., work-related demands exacerbated by the pandemic).DiscussionOur study highlights COVID-19 and other pandemic-related challenges that negatively impacted the mental health of physicians. Interventions that provide targeted organizational supports (e.g. sufficient PPE and child support), as well as specific sources of support (e.g. family and emotional), can attenuate those challenges and stressors experienced during a pandemic.
Short-course antidepressant therapy reduces discontinuation syndrome while maintaining treatment efficacy in patients with refractory functional dyspepsia: A randomized controlled trial
Authors: Wang Qian-Qian , Cheng Li , Wu Bi-Yu , Xu Ping , Qiu Hong-Yi , Wang Bo , Yan Xiu-Juan , Chen Sheng-Liang 
Published: December 2022

Background and objectiveLong-course (LC) antidepressants for the treatment of disorders of gut-brain interaction, such as refractory functional dyspepsia (rFD), pose patients at risk of antidepressant discontinuation syndrome (ADS). Short-course (SC) therapy of rapid-acting antidepressant may reduce discontinuation syndromes while maintaining efficacy for dyspeptic symptoms. However, the evidence-based research is lacking. This study aims to determine whether SC therapy with antidepressants could decrease the risk of ADS with comparable treatment efficacy to LC therapy in rFD.MethodsThis randomized clinical trial with rFD patients was conducted at a tertiary hospital in China. Participants (N = 240) were randomly allocated to receive flupentixol-melitracen (FM) plus omeprazole therapy for 2 (SC group) or 4 (LC group) weeks, respectively. Scores for Leeds Dyspepsia Questionnaire (LDQ), Generalized Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire-9 for Depression (PHQ-9) were assessed at baseline and every 2 weeks, ending at 4 weeks after treatment. ADS was assessed after drug cessation. Medication possession ratio (MPR) for FM was calculated.ResultsThe severity and incidence of ADS of patients in SC group were significantly lower than those in LC group (0.60 ± 0.62 vs. 1.71 ± 1.58 and 3.64 vs. 39.45%; both P &lt; 0.0001). The MPR values for FM were significantly higher in patients of SC group than in LC group (P &lt; 0.0001). Scores for LDQ, GAD-7 and PHQ-9 decreased in patients of both groups, and the symptom improvement in SC group was comparable to that in LC group after treatment.ConclusionsCompared to 4-week FM therapy, the 2-week FM therapy reduces the risk of ADS with non-inferior treatment efficacy in patients with rFD.Clinical trial registrationClinical trials.gov, identifier NCT05099913.
Association between BMI and health-related physical fitness: A cross-sectional study in Chinese high school students
Authors: Qin Guoyang , Qin Yong , Liu Bin 
Published: December 2022

BackgroundExisting studies reporting on the levels of physical fitness among high school students use relatively few fitness tests for indicators of physical fitness, thus, incomprehensively evaluating the levels of physical fitness. Therefore, this study investigated the relationship between body mass index (BMI) and physical fitness index (PFI) by investigating five physical fitness indicators and calculating PHI.MethodAnthropometric measurements and indicators from five measures of physical fitness (50-m sprint, sit and reach, standing long jump, 800/1,000-m run, pull-up/bent-leg sit-up) were assessed. BMI was calculated to classify individuals into underweight, normal weight, overweight, and obese categories. Z-scores based on sex-specific mean and standard deviation were calculated, and the sum of Z-scores from the six fitness tests indicated the PFI. The findings were fitted to a linear regression model to elucidate the potential relationship between BMI and PFI.ResultsIn total, 176,655 high school students (male: 88,243, female: 88,412, age: 17.1 ± 1.05 years, height: 168.87 ± 11.1 cm, weight: 62.54 ± 15.15 kg) in Jinan, China, completed the physical fitness tests between 2020 and 2021. The one-way ANOVA models showed that PFI in the normal category was significantly higher as compared to all the other BMI categories within both male and female groups (p &lt; 0.001), and PFI in the obese category was significantly lower as compared to all the other BMI categories for both male and female groups (p &lt; 0.001). The association between PFI and BMI showed an inverted U-shape relationship.ConclusionsThis study demonstrated that BMI affects the PFI in both males and females. As compared to the obese and overweight categories based on BMI, significantly higher scores of PFI were observed for males and females.
Two decades of experience in explantation and graft preserving strategies following primary endovascular aneurysm repair and lessons learned
Authors: Sultan Sherif , Acharya Yogesh , Hezima Mohieldin , Chua Vi Long Keegan , Soliman Osama , Parodi Juan , Hynes Niamh 
Published: December 2022

ObjectivesWe aim to scrutinize our evolving re-intervention strategies following primary endovascular aortic aneurysm repair (EVAR) - EVAR GORE SalvAge Fabric Technique (ARAFAT), aortic sac double breasting with endograft preservation, and stent-graft explantation.MethodsWe performed 1,555 aortic interventions over the study period, including 910 EVARs. Factors associated with the need for reintervention and the likelihood of chronic fabric fatigue failure (CFFF) were investigated. Using conventional and innovative diagnostic modalities with Prone contrASt enHanced computed tomography Angiography (PASHA), 136 endoleaks (ELs) were identified (15 type I, 98 type II; 18 type III; 5 type IV).ResultsForty-four (4.84%) patients underwent re-intervention post-primary EVAR; 18 ARAFATs, 12 double breastings, and 14 explantations. Choice of re-intervention was based on patient fitness and mode of failure. Mean EL detection duration following primary EVAR was 53.3 ± 6.82 months, while mean time to re-intervention was 70.20 ± 6.98 months. The mean sac size before the primary EVAR and re-intervention was 6.00 ± 1.75 cm and 7.51 ± 1.94 cm, respectively. Polyester (61.40%) was the most commonly employed stent-graft material. Use of more than three modular stent-graft components (3.42 ± 1.31, p = 0.846); with the proximal stent-graft diameter of 31.6 ± 3.80 cm (p = 0.651) and the use of iliac limbs more than 17 mm (p = 0.364), all added together are contributing factors. We had one peri-operative mortality following explantation due to sepsis-induced multiorgan failure.ConclusionsOur re-intervention strategies matured from stent graft explantation to graft preservation with endovascular relining of the stent-graft. Graft preservation with aortic sacotomy and double breasting were used to manage concealed ELs due to aortic hygroma.
Assessment of the utility of platelet indices to diagnose clinical benign prostatic hyperplasia in dogs
Authors: Hosseinpour Hediyeh , Ahmadi-hamedani Mahmood , Masoudifard Majid , Shirani Darush , Narenj Sani Reza 
Published: December 2022

IntroductionPlatelet indices changes in severely ill people and in dogs with inflammation are compatible findings. This study aimed to compare platelet indices between dogs with clinical benign prostatic hyperplasia (BPH) and healthy controls. Additionally, to determine whether there is a correlation between the relative prostatic size (Srel) and the platelet indices in BPH dogs.MethodsThirty-five adult intact male dogs of different breeds were allocated to the experimental groups: dogs with clinical BPH (groups A;n= 24; median age of 6 years; the median weight of 8.50 kg) and healthy dogs (group B;n= 11; median age 5.50 years; the median weight of 7.00 kg) based on physical examination, clinical signs, andSreldetected by ultrasonographic findings. The individual prostatic volume (IPV) was divided by the expected prostatic volume (EPV) to determine the relative prostatic size in dogs over 4 years old. Platelet indices were compared between the two groups, and a correlation betweenSreland these indices was calculated.ResultsThe medianSrelof dogs in group A was significantly higher (P= 0.001), and the mean plateletcrit (PCT) was significantly lower (P= 0.003) compared with those in group B.Srelshowed a significant negative correlation with PLT and PCT (r= −0.388;P= 0.02 andr= −0.402;P= 0.01). Receiver operating characteristic (ROC) analysis showed PLT and PCT thresholds for estimatingSrel&gt; 1 with 75% and 87.5% sensitivity and 71.82 and 63.64% specificity.DiscussionThe findings of this study support the use of platelet indices like PLT and PCT to detect clinical BPH in dogs. However, more research is needed to confirm their utility in conjunction with other previously described diagnostic factors.
Research on the Relationship between Physical Literacy, Physical Activity and Sedentary Behavior
Authors: Yan Wenjing , Meng Yihan , Wang Lina , Zhang Ting , Chen Leqin , Li Hongjuan 
Published: December 2022

During the COVID-19 pandemic, college students’ health-related physical activity and physical literacy aroused widespread concern. This study evaluated the relationship among physical literacy (PL), sedentary behavior (SB), light physical activity (LPA), and moderate-to-vigorous physical activity (MVPA); we further explored whether LAP and SB mediated the association between PL and MVPA. Methods: This study was based on a cross-sectional survey of Chinese college students. The Perceived Physical Literacy Instrument Scale (PPLI-SC) and International Physical Activity Questionnaire Short Form (IPAQ-SF) were used to investigate the PL, MVPA, LPA, and SB. Results: There were 2996 valid questionnaires with 829 boys and 2167 girls. The MVPA, LPA, and PL of boys were significantly higher than girls, while the SB values were significantly lower in girls (p < 0.01). The correlation analysis showed that there was a significant correlation between the two indexes except for SB and LPA. Path analysis shows that PL directly, significantly, and positively affects MVPA. PL reduces SB (β = −0.085, p < 0.001) and increases LPA (β = 0.097, p < 0.001). The total mediation effect accounted for 14.014%, and the mediation effects of SB and LPA accounted for 4.417% and 9.597%, respectively. Conclusions: LPA and SB partially mediated the relation between PL and MVPA. SB and LPA partially explain the impact of PL on MVPA. The findings suggest that managing SB and improving LPA could play a significant indirect role in increasing the positive effect of PL on MVPA and that increasing the opportunities for LPA increased the MVPA for Chinese college students.
Bêta-lactamases BLSE de type CTX-M
Authors: Philippon Alain , Arlet Guillaume , Iorga Bogdan I. 
Published: December 2022

Dans les années 1980, la prescription des premières céphalosporines de troisième génération (C3G) en médecine humaine a provoqué la sélection de mutants ou variants de pénicillinases de type TEM ou SHV dénommées : «Bêta-Lactamases à Spectre Elargi/ Etendu » ou BLSE. Dans les années 1990 ont émergé de nouvelles enzymes ou CéfoTaXimases-München (CTX-M), transférables, inactivant les C3G, certaines étant devenues pandémiques. Elles sont maintenant retrouvées dans les trois écosystèmes (homme, animal, environnement) et leur grande diffusivité est liée à l’insertion du gène blaCTX-M (plasmide, transposon, intégron, séquence d’insertion) et à son association à d’autres gènes : des gènes de résistance par exemple aux fluoroquinolones et/ ou aminoglycosides, mais aussi des gènes de virulence. Ces phénomènes ont conduit à la notion de clone majoritaire, en particulier chez l’homme, comme Escherichia coli ST131 du groupe phylogénétique B2 et du sérotype O25b ou H4 producteur du variant CTX-M-15. Ces gènes, d’une grande diversité, retrouvés chez de nombreux animaux (volailles, bovins, ovins…, voire les coquillages et les mouches) sont issus d’entérobactéries du genre Kluyvera
dont la taxonomie et l’habitat restent à être mieux précisés.