bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D-QSAR, Molecular Docking and Pharmacokinetic Studies: In-Silico Approach to Search Novel Inhibitors of 5-Alpha Reductase for Treatment of Benign Prostatic Hyperplasia
Authors: Dhingra Neelima , Kaur Harnoor , Kumari Alka , Rana Priyanka , Kaur Tanzeer 
Published: September 2022

Aim:To identify novel steroidal 5-alpha reductase (5AR) inhibitors using computational approaches.Objectives:To exploit the steroidal nuclei for possible modifications by creating a library of 17-oximino-5-androsten-3-carboxamide derivatives and identify potent 5AR inhibitors based on docking and pharmacokinetic parameters.Background:Benign prostatic hyperplasia (BPH), is a condition of aged men, that is characterized by lower urinary tract symptoms. Excessive production of dihydrostestosterone (DHT) from testosterone has been found to play a major role in its pathophysiology. Studies targeting the 5AR enzyme have so far resulted in the development of two clinical approved 5AR inhibitors.Methods:Atom-based three dimensional-quantitative structure activity relationship (3D-QSAR) models have been developed using a selected series of steroidal derivatives as 5AR inhibitors, to elucidate the structural properties required for 5AR inhibitory activities. Further In‒silico studies (molecular docking and pharmacokinetic properties like adsorption, distribution, metabolism, and excretion) of 17-oximino-5-androsten-3-carboxamide derivatives have also been carried out to identify the binding orientation and protein-ligand interactions responsible for the exhibited activity and drug like properties.Results:The best 3D-QSAR model was generated using Partial Least Square method with an excellent correlation coefficient (R², training set) of 0.882, standard deviation (SD) of 0.09, and a predicted coefficient (Q², test set) of 0.814. Docking analysis indicated that the designed series of compounds have comparable binding affinity from -8.961 to -8.017 to the protein and suggested that hydrophobic and electrostatic moieties can have a key role in the inhibition mechanism.Conclusion:3D-QSAR, molecular docking and pharmacokinetic studies indicated that 17-oximino-5-androsten-3-carboxamide derivatives could be studied further to provide a new strategy for the treatment of BPH.
A Cellular Senescence-Centric Integrated Approach to Understanding
Organismal Aging
Authors: Sharma Rohit , Diwan Bhawna 
Published: September 2022

Abstract:
Aging remains the fundamental cause of the increased rate of morbidity and mortality in
the elderly. Despite continuing research, an integrative and holistic understanding of the molecular
mechanisms and effects of aging is still elusive. This presents a major challenge in biogerontology,
and therefore novel strategies aimed at integrating the multifaceted nature of aging for the identification
and development of successful therapeutic targets are highly desirable. At present, cellular
senescence, immunosenescence, and gut microbiota dysbiosis are key known modulators of aging.
However, a cellular senescence-centric integrative view that relates to the seemingly distinct processes
of immunosenescence and gut microbiota dysbiosis can be envisaged, which implies a more
inclusive and targetable understanding of aging. The present manuscript discusses the emerging evidence
and significance of cellular senescence vis-à-vis immunosenescence and gut microbiota
dysbiosis in the development of potential anti-aging therapies. Underlying interconnections and
mechanisms amongst these individual modulators have been deliberated to present a more coherent
and tangible understanding of biological aging. It is emphasized that aging be studied within the
integrative purview of these processes that may ultimately help devise a new inclusive and consolidated
theory of aging with well-defined therapeutic targets.
Toxicological Analysis of Drugs in Human Mummified Bodies and
Proposed Guidelines
Authors: Silva-Bessa Angela , Dinis-Oliveira Ricardo Jorge , Forbes Shari L. , Ferreira Maria Teresa 
Published: September 2022

Abstract:
From palaeopathology to forensic taphonomy, mummified human bodies constitute
biological archives of paramount importance. Toxicology analysis of endobiotics and xenobiotics
has already shown value to archaeological mummies research with detecting heavy metals,
sedative-hypnotic drugs, and stimulants. Thanks to the large window of drug detection in hair and
nails, the information from such studies has increased the scientific community’s knowledge
regarding past populations’ lifestyles. Still, few bibliographic references exist regarding toxicology
reports in mummified bodies from forensic settings. Here, the authors aim to draw attention to the
valuable contribution of toxicology analysis, taking into account previously conducted studies and
their findings. Given that sample collection on mummified bodies from forensic scenarios may not
always happen in laboratories or autopsy rooms, the authors also suggest guidelines for in situ
sampling of forensic mummies. It is expected that the present technical note will encourage experts
to perform toxicology analysis in mummified bodies and publish their case reports more often.
Differentiated Effects and Determinants of Home Blood Pressure Telemonitoring: Three-Year Cohort Study in Jieshou, Anhui, China
Authors: Xue Qun , Zhang Xuewu , Liu Rong , Guan Xiaoqin , Li Guocheng , Zhao Linhai , Wang Qian , Wang Debin , Shen Xingrong 
Published: September 2022

Background
Home blood pressure telemonitoring (HBPT) is witnessing rapid diffusion worldwide. Contemporary studies documented mainly short-term (6-12 months) effects of HBPT, and there are limited data about its uptake.

Objective
The aim of this study was to explore the 3-year use and determinants of HBPT, and the interactions with systolic and diastolic blood pressure (SBP/DBP) and overall blood pressure (BP) control rate.

Methods
HBPT records were obtained from a 3-year cohort of 5658 patients with hypertension in Jieshou, Anhui, China, and data from a structured household survey of a random sample (n=3005) of the cohort. The data analysis comprised (1) timeline trajectories of the rates of monthly active HBPT and mean SBP/DBP for overall and subgroups of patients with varied start-month SBP/DBP; and (2) multivariable linear, logistic, and percentile regression analyses using SBP/DBP, BP control rate, and yearly times of HBPT as the dependent variable, respectively.

Results
HBPT was followed by mixed changes in mean monthly SBP/DBP for varied patient groups. The magnitude of changes ranged from –43 to +39 mmHg for SBP and from –27 to +15 mmHg for DBP. The monthly rates of active HBPT all exhibited a rapid and then gradually slower decline. When controlled for commonly reported confounders, times of HBPT in the last year were found to have decreasing correlation coefficients for SBP/DBP (from 0.16 to –0.35 and from 0.11 to –0.35, respectively) and for BP control rate (from 0.53 to –0.62).

Conclusions
HBPT had major and “target-converging” effects on SBP/DBP. The magnitude of changes was much greater than commonly reported. BP, variation in BP, and time were the most important determinants of HBPT uptake. Age, education, duration of hypertension, family history, and diagnosis of hypertension complications were also linked to the uptake but at weaker strength. There is a clear need for differentiated thinking over the application and assessment of HBPT, and for identifying and correcting/leveraging potential outdated/new opportunities or beliefs.
Supporting Shared Decision-making About Surveillance After Breast Cancer With Personalized Recurrence Risk Calculations: Development of a Patient Decision Aid Using the International Patient Decision AIDS Standards Development Process in Combination With a Mixed Methods Design
Authors: Ankersmid Jet Wies , Siesling Sabine , Strobbe Luc J A , Meulepas Johanna M , van Riet Yvonne E A , Engels Noel , Prick Janine C M , The Regina , Takahashi Asako , Velting Mirjam , van Uden-Kraan Cornelia F , Drossaert Constance H C 
Published: September 2022

Background
Although the treatment for breast cancer is highly personalized, posttreatment surveillance remains one-size-fits-all: annual imaging and physical examination for at least five years after treatment. The INFLUENCE nomogram is a prognostic model for estimating the 5-year risk for locoregional recurrences and second primary tumors after breast cancer. The use of personalized outcome data (such as risks for recurrences) can enrich the process of shared decision-making (SDM) for personalized surveillance after breast cancer.

Objective
This study aimed to develop a patient decision aid (PtDA), integrating personalized risk calculations on risks for recurrences, to support SDM for personalized surveillance after curative treatment for invasive breast cancer.

Methods
For the development of the PtDA, the International Patient Decision Aids Standards development process was combined with a mixed methods design inspired by the development process of previously developed PtDAs. In the development, 8 steps were distinguished: establishing a multidisciplinary steering group; definition of the end users, scope, and purpose of the PtDA; assessment of the decisional needs of end users; defining requirements for the PtDA; determining the format and implementation strategy for the PtDA; prototyping; alpha testing; and beta testing. The composed steering group convened during regular working-group sessions throughout the development process.

Results
The “Breast Cancer Surveillance Decision Aid” consists of 3 components that support the SDM process: a handout sheet on which personalized risks for recurrences, calculated using the INFLUENCE-nomogram, can be visualized and which contains an explanation about the decision for surveillance and a login code for a web-based deliberation tool; a web-based deliberation tool, including a patient-reported outcome measure on fear of cancer recurrence; and a summary sheet summarizing patient preferences and considerations. The PtDA was assessed as usable and acceptable during alpha testing. Beta testing is currently ongoing.

Conclusions
We developed an acceptable and usable PtDA that integrates personalized risk calculations for the risk for recurrences to support SDM for surveillance after breast cancer. The implementation and effects of the use of the “Breast Cancer Surveillance Decision Aid” are being investigated in a clinical trial.
Karakterisasi Longsor untuk Analisis Kerawanan Bencana Longsor di Baturturu, Kabupaten Gunungkidul
Authors: Wicaksono Aditya Pandu , Khafid Mohammad Abdul 
Published: September 2022

Abstrak Kabupaten Gunungkidul merupakan daerah dengan intensitas bencana longsor cukup tinggi. Bencana longsor terjadi di Dusun Baturturu, Kabupaten Gunungkidul dipengaruhi oleh tingginya intensitas curah hujan yang berdampak pada kerugian material. Tujuan dari penelitian ini untuk mengetahui karakteristik, kerawanan longsor, dan kestabilan lereng sebagai upaya mitigasi bencana untuk meminimalkan risiko bencana. Penelitian ini menggunakan metode pemodelan spasial kuantitatif berjenjang untuk pengharkatan kerawasan longsor dengan pengambilan sampel menggunakan kaidah purposive sampling. Analisis laboratorium juga digunakan sebagai data analisis kestabilan lereng dengan metode janbu dan fellenius. Hasil penelitian menunjukkan bahwa tipe longsor daerah penelitian yaitu Rotational Slide.. Daerah penelitian memiliki 3 kelas kerawanan longsor yaitu rendah (skor 17), sedang (skor 19-22), dan tinggi (skor 24-25). Sedangkan hasil analisis kestabilan lereng pada daerah dengan kerawanan tinggi berada pada level kritis atau potensial untuk terjadi longsor dengan FK= 0,546 dengan metode Janbu. Sedangkan metode fellenius di dapatkan hasil masing-masing sebesar 1,821, 1,292, dan 1,768 (level stabil) yang artinnya kondisi lereng tersebut masih tergolong aman dari potensi pergerakan tanah. Abstract Gunungkidul regency is an area with a high landslide intensity. Landslide disaster occurred in Baturturu Hamlet, Gunungkidul Regency affected by the high intensity of rainfall that impacted material losses. The purpose of this study is to find out the characteristics, level of landslide insecurity, and slope stability as a disaster mitigation effort to minimize disaster risk. This study used a tiered quantitative spatial modeling method for the assessment of landslide insights by sampling using purposive sampling rules. Laboratory analysis is also used as slope stability analysis data by janbu and fellenius methods. The results showed that the type of landslide of the research area is a rotational landslide. The research area has 3 classes of landslide insecurity, namely low (score 17), moderate (score 19-22), and high (score 24-25). Meanwhile, the results of the slope stability analysis in areas with high vulnerability are at a critical level or the potential for landslides to occur with FK = 0.546 with the Janbu method. Meanwhile, the fellenius method obtained results of 1,821, 1,292, and 1,768 (stable levels) respectively, which means that the condition of the slopes is still relatively safe from potential soil movement.
Profit Shifting during Foreign Tax Holidays
Authors: Chow Travis K. , Hoopes Jeffrey L. , Maydew Edward L. 
Published: September 2022

ABSTRACT
We undertake the first empirical analysis of profit shifting by U.S. firms during foreign tax holidays. We show that foreign tax holidays have become a prevalent and powerful tax planning strategy among U.S. firms. We find that U.S. firms significantly increase their outbound profit shifting while participating in foreign tax holidays. However, we also find that profit shifting associated with tax holidays comes at the cost of increased tax uncertainty. Our results have important implications for policy making and for understanding firm behavior.
Effects of Dietary L-Proline and L-Alanine on Growth Performance, and Flesh Quality of Common Carp (Cyprinus carpio) Juveniles
Authors: Taziki Taghi , Jafari Valiollah , Mazandarani Mohammad , Hoseinifar Seyed Hossein 
Published: September 2022

Abstract
The purpose of the present study was to investigate the effects of amino acids L-proline and L-alanine on growth performance, amino acid, and fatty acid levels in the fillet of juvenile common carp. Four hundred and fifty juvenile common carp were randomly distributed in 30 tanks and fed with three levels of proline (5 [P5], 10 [P10], and 15 [P15] g/kg), three levels of alanine [A] (5 [A5], 10 [A10], and 15 [A15] g/kg), three levels of proline-alanine combination [PA] (2.5 + 2.5 [2.5PA], 5 + 5 [5PA], 7.5 + 7.5 [7.5PA] g/kg feed) and basal diet (control). The highest body weight gain (25.85 ± 0.1 g) and survival rate (91.11 ± 3.84) were observed in 7.5 PA treatment. The highest protein content (64.58 ± 0.49) was noticed in 2.5 PA; however, compared to combined treatments (5 PA and 2.5 PA), it did not show any significant difference (P<0.05). The highest total amount of essential amino acids (48.30 ± 48.3) was observed in 7.5 PA treatment. The highest amount of DHA (5.65 ± 0.08), total EPA, and DHA (8.91 ± 0.13) were in 7.5 PA treatment. Finally, it can be concluded that two amino acids L-proline and L-alanine at the combined level of 5 PA can improve the growth performance, survival, and fillet composition in the juvenile common carp.
Bioactive compounds, antibiotics and heavy metals: Effects on the intestinal structure and microbiome of monogastric animals – a non-systematic review
Authors: Winiarska-Mieczan Anna , Kwiecień Małgorzata , Jachimowicz-Rogowska Karolina , Muszyński Siemowit , Tomaszewska Ewa 
Published: September 2022

Abstract
The intestinal structure and gut microbiota are essential for the animals’ health. Chemical components taken with food provide the right environment for a specific microbiome which, together with its metabolites and the products of digestion, create an environment, which in turn affects the population size of specific bacteria. Disturbances in the composition of the gut microbiota can be a reason for the malformation of guts, which has a decisive impact on the animal’s health. This review aimed to analyse scientific literature, published over the past 20 years, concerning the effect of nutritional factors on gut health, determined by the intestinal structure and microbiota of monogastric animals. Several topics have been investigated: bioactive compounds (probiotics, prebiotics, organic acids, and herbal active substances), antibiotics and heavy metals (essential minerals and toxic heavy metals).
Potential protective effects of thyme (Thymus vulgaris) essential oil on growth, hematology, immune responses, and antioxidant status of Oncorhynchus mykiss exposed to malathion
Authors: Jasim Saade Abdalkareem , Davoodi Reza , Yasin Ghulam , Shichiyakh Rustem Adamovich , Alkadir Ola Kamal A. , Taifi Ahmed , Mustafa Yasser Fakri , Abarghouei Safoura 
Published: September 2022

Abstract
As an abundant source of antioxidants and diet flavor enhancers, the plant essential oils can have positive effects on fish growth, and resistance against environmental stressors. In this study, garden thyme (Thymus vulgaris) essential oil (TEO) was used in the diet of rainbow trout, Oncorhynchus mykiss, to evaluate its protective effect against malathion pesticide exposure. Tested fish (19.99±0.01 g) were divided into six groups (three replicates), namely: T1: control diet; T2: control diet + 0.025 mg L−1 malathion; T3: control diet + 0.075 mg L−1 malathion; T4: control diet + 1% TEO; T5: control diet + 0.025 mg L−1 malathion + 1% TEO and T6: control diet + 0.075 mg L−1 malathion + 1% TEO. After 21 days, T4 fish had the highest final body weight (FW), weight gain (WG), specific growth rate (SGR), and the lowest feed conversion ratio (FCR) among experimental treatments (P<0.05). The blood parameters including the red blood cells (RBC), white blood cell count (WBC), hematocrit (Hct), and hemoglobin (Hb) values were the highest in T4 treatment, displaying a significant difference with T1 treatment (P<0.05). Fish in the T4 groups had the highest total protein (TP) and albumin (ALB), while fish of T3 showed the lowest levels of these parameters (P<0.05) and also had the highest level of triglycerides (TRG), cholesterol (CHOL), lactate dehydrogenase (LDH), and urea (Ur). Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) enzymes recorded the lowest levels in T4 treatment, which showed a significant difference with T1 group. The catalase (CAT) and superoxide dismutase (SOD) showed the highest activities in T4 treatment, while the lowest SOD and the highest malondialdehyde (MDA) levels occurred in T3 group (P<0.05). Total immunoglobulin (total Ig) level, alternative complement (ACH50) and lysozyme in the serum and skin mucus of T4 treatment of rainbow trout showed the highest activities with a significant difference from groups (P<0.05). From the results of the present study, it can be concluded that 1% of T. vulgaris as a supplement to the diet of rainbow trout can stimulate and improve the immune system of the fish. TEO can have a protective effect against unfavorable effects of malathion and improves the growth of the fish.
Performance Indicators, Coccidia Oocyst Counts, Plasma Biochemical Parameters and Fermentation Processes in the Cecum of Rabbits Fed a Diet with the Addition of Black Cumin Seed Meal
Authors: Strychalski Janusz , Kowalska Dorota , Grinholc Sławomir , Juśkiewicz Jerzy , Fotschki Bartosz , Gugołek Andrzej 
Published: September 2022

Abstract
The aim of this study was to determine the effects of dietary supplementation with black cumin seed meal on growth performance parameters, coccidia oocyst counts, plasma biochemical parameters and cecal fermentation processes in growing rabbits. A total of 40 male Californian rabbits at 35 days of age were divided into two feeding groups: Control (complete rabbit diet) and Black cumin (2% of the complete diet was replaced with black cumin seed meal). Dietary supplementation with black cumin did not affect growth performance parameters, but it reduced coccidia oocyst counts in the feces of 63-day-old rabbits. Increased liver weight and elevated plasma albumin levels were noted in these rabbits. A significant decrease in small intestinal digesta viscosity was also observed in rabbits fed a diet supplemented with black cumin seed meal. The above change suppressed the formation of putrefactive compounds, i.e. ammonia and branched short-chain fatty acids (SCFA s) in the cecum, but it did not decrease the production of major SCFA s, i.e. acetic, propionic and butyric acids. The current study demonstrated that the dietary addition of 2% black cumin seed meal exerted a modulatory effect on gastrointestinal function, but it did not compromise microbial enzyme activity or SCFA production in the cecum.
Training during recessions: recent European evidence
Authors: Bertoni Marco , Brunello Giorgio 
Published: September 2022

Abstract
We use European Union Labour Force Survey data for the period 2005–2018 to investigate the cyclicality of training in Europe. Consistent with the view that firms use recessions as times to update skills, we find that training participation is moderately countercyclical for the employed. Within the not-employed group, this is true also for the unemployed, who are likely to be involved in public training programs during recessions, but not for the inactive, who may be affected by liquidity constraints.
Spontaneous epidural hematoma induced by rivaroxaban: A case report and review of the literature
Authors: Siahaan Andre Marolop Pangihutan , Tandean Steven , Nainggolan Bahagia Willibrordus Maria 
Published: September 2022

Background:
Trauma is the most frequent reason for epidural bleeding. However, numerous investigation had discovered that anticoagulants such as rivaroxaban could cause epidural hematoma. Here, we present a case of epidural hematoma in young man who got rivaroxaban as treatment of deep vein thrombosis.

Case Description:
A 27-year-old male with a history of deep vein thrombosis and one month of rivaroxaban medication presented with seizure and loss of consciousness following a severe headache. A CT scan of the head revealed epidural bleeding, and emergency blood clot removal was performed. As a reversal, prothrombin complex was utilized.

Conclusion:
Rivaroxaban has the potential to cause an epidural hemorrhage. Reversal anticoagulant should be administered before doing emergency surgery.
Does diploic venous flow drain extracranially in the pterional area? A magnetic resonance imaging study
Authors: Tsutsumi Satoshi , Sugiyama Natsuki , Ueno Hideaki , Ishii Hisato 
Published: September 2022

Background:
To the best of our knowledge, no study using neuroimaging modalities has documented calvarial diploic veins (DVs) connected to the extracranial sites. This study aimed to characterize them using magnetic resonance imaging (MRI).

Methods:
A total of 88 patients underwent thin-sliced contrast MRI. In addition, the DVs coursing through the pterional area were observed on three injected cadaver heads.

Results:
On postcontrast MRI, the DVs of the pterional area directly drained into the temporalis muscle or supplied branches coursing into the muscle in 43% on the right side and 40% on the left. The DVs and their branches were highly variable in diameter and number. In 9% of cases, the DV of the pterional area was found to drain into an extracranial site and connected to large venous channels distributed in the temporalis muscle. Furthermore, in 17% of cases, the DVs drained into the extracranial sites in the frontal skull region, followed by 9% in the parietal, 2% in the occipital, and 1% in the temporal regions. The DVs coursed superficially in the pterional area on both sides of all three cadaver heads. On one side, the DV in the area was open to an extracranial site.

Conclusion:
Part of the diploic venous flow drains extracranially in the pterional area. This area may provide an important interface between the calvarial DVs and the extracranial venous system.