bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between night pain and quality of life in women: A general population sleep study
Authors: Lucena Leandro , Lavigne Gilles , Fabbro Cibele Dal , Andersen Monica Levy , Tufik Sergio , Hachul Helena 
Published: December 2022

AbstractBackgroundWomen with pain present decreased sleep duration and quality of life, but little is known about the consequences of nighttime pain on overall health. Our goal was to compare levels of anxiety, depression and fatigue in women with pain during the night with those without pain. We hypothesized that pain perception is associated with the worsening of fatigue and mood.MethodsIn total, 244 women aged 20–80 years who took part in the Epidemiologic Sleep Study (EPISONO) met the inclusion criteria, 85 in the self‐reported pain group and 171 in the control group. Participants were assigned to the pain group if they both responded (i) they generally had pain, according to Pre‐Sleep Questionnaire (PSQ) and (ii) their pain generally interfered with their sleep 3 or more times a week, according to Pittsburg Sleep Quality Index (PSQI). Those who answered negatively to both questions were allocated to the control group. All participants underwent a full night laboratory polysomnography, and completed questionnaires related to fatigue, depression, anxiety and quality of life.ResultsPain group participants had a significantly lower perception of quality of life, and significantly higher levels of fatigue (5.4 times), anxiety and depression. Pain perception was also correlated to levels of anxiety and depression in the psychological (rs = −0.463, −0.607, respectively) and social (rs = −0.423, −0.438, respectively) quality of life domains.ConclusionsNighttime pain in women was associated with decreased quality of life, worsening mood and fatigue. Our data shows the importance of investigating pain and its deleterious effects on women's health.SignificanceOur study highlights that women experiencing nighttime pain also reported worse mood outcomes and decreased quality of life, regardless of the level and type of pain. Our data, based on association analysis and not investigating causality, suggest it is important to consider nighttime pain in clinical care to improve quality of life and general health.
Differential characterization of volatile components and aroma sensory properties of different types of Hehong tea (Congou black tea)
Authors: Yue Cuinan , Li Wenjin , Li Chen , Wang Zhihui , Peng Hua , Yang Puxiang 
Published: December 2022

AbstractTo explore the flavour characteristics and their different molecular mechanisms of different types of Hehong tea (Gongya, GY; Congou, CG and Laocong, LC) from the perspective of dry tea, we investigated their volatile compounds and sensory aroma sub‐attribute characteristics by headspace–solid phase microextraction–gas chromatography–mass spectrometry (HS‐SPME‐GC–MS), quantitative description analysis (QDA), and chemometrics. A total of 42 volatile compounds were identified in Hehong tea, of which alcohol content was the highest, the number of esters was the largest and pyrrole showed the largest differences. The volatile components of GY and LC differed, whereas those of CG and LC were more similar. There were 34 volatile components with a significant difference in the three types of Hehong tea. We established the aroma quantitative system of Hehong tea by using QDA. We found that sweety was probably the symbolic aroma sub‐attribute of Hehong tea, and woody was the characteristic sub‐attribute of LC, and there was a certain correlation among the aroma sub‐attributes. A total of 21 volatile components importantly contributed to the aroma sub‐attributes of Hehong tea. Furthermore, we screened out 18 marker volatile compounds that may be used as important indicators for distinguishing the three types of Hehong tea. Our findings add to our understanding of the flavour characteristics and aromas of the three types of Hehong tea and provide new strategies and thoughts for the evaluation of tea flavour using dry tea.
Identification of a novel recurrent EEF2 gene amplification in familial prostate tumors
Authors: Raspin Kelsie , Marthick James R. , Donovan Shaun , Blizzard Leigh , Malley Roslyn C. , Jung Chol‐hee , Banks Annette , Redwig Frank , Skala Marketa , Dickinson Joanne L. , FitzGerald Liesel M. 
Published: December 2022

AbstractRecurrent tumor copy number variations (CNVs) in prostate cancer (PrCa) have predominantly been discovered in sporadic tumor cohorts. Here, we examined familial prostate tumors for novel CNVs as prior studies suggest these harbor distinct CNVs. Array comparative genomic hybridization of 12 tumors from an Australian PrCa family, PcTas9, highlighted multiple recurrent CNVs, including amplification of EEF2 (19p13.3) in 100% of tumors. The EEF2 CNV was examined in a further 26 familial and seven sporadic tumors from the Australian cohort and in 494 tumors unselected for family history from The Cancer Genome Atlas (TCGA). EEF2 overexpression was observed in seven PcTas9 tumors, in addition to seven other predominantly familial tumors (ntotal = 34%). EEF2 amplification was only observed in 1.4% of TCGA tumors, however 7.5% harbored an EEF2 deletion. Analysis of genes co‐expressed with EEF2 revealed significant upregulation of two genes, ZNF74 and ADSL, and downregulation of PLSCR1 in both EEF2 amplified familial tumors and EEF2 deleted TCGA tumors. Furthermore, in TCGA tumors, EEF2 amplification and deletion were significantly associated with a higher Gleason score. In summary, we identified a novel PrCa CNV that was predominantly amplified in familial tumors and deleted in unselected tumors. Our results provide further evidence that familial tumors harbor distinct CNVs, potentially due to an inherited predisposition, but also suggest that regardless of how EEF2 is dysregulated, a similar set of genes involved in key cancer pathways are impacted. Given the current lack of gene‐based biomarkers and clinical targets in PrCa, further investigation of EEF2 is warranted.
Laryngectomy: Social media analysis of patient perception
Authors: Moffatt David C. , Lahaye Joshua J. , Corona Kassandra K. , Rossi Nicholas A. , Joshi Rohan , Resto Vicente , McKinnon Brian J. , Coblens Orly M. 
Published: December 2022

AbstractBackgroundSocial media continues to grow as a relevant information source for the lay public and medical professionals.MethodsA search of posts on Facebook and Instagram was conducted using the hashtag #laryngectomy. Posts were categorized based upon perspective, media type, timeframe, topic, tone, and popularity.ResultsFinal analysis included 929 Instagram posts and 355 Facebook posts. Most Facebook posts were made by companies (38%) and physicians (17%) with information (30%) and advertisements (22%) being common topics. Patients (40%) were the largest group of Instagram authors with lifestyle (39%) being the most common topic. Greater than 90% of posts were either neutral or positive in tone across both platforms.ConclusionsPatient perspective was most commonly represented on Instagram, whereas Facebook more commonly included posts by physicians and companies. The majority of posts carried a neutral or positive tone, which is consistent with positive quality of life patients have shown postoperatively.
Perceived stress among older adults during COVID‐19 outbreak: A cross‐sectional study in Southern Iran
Authors: Shahabi Nahid , Mohseni Shokrollah , Dadipoor Sara , Rad Roghayeh E. , Hassani Laleh 
Published: December 2022

AbstractBackground and AimsThe stress associated with the coronavirus disease 2019 (COVID‐19) pandemic significantly affects people's lives, especially older adults. The present study aimed to identify risk factors leading to the perceived stress associated with COVID‐19 among the adults over 60 years old of Southern Iran.MethodsThis cross‐sectional study was conducted in December 2021 in Bandar Abbas among older adults. The COVID‐PSS‐10 (Perceived Stress Scale) questionnaire was distributed among the older adults receiving healthcare services from health centers in Bandar Abbas selected through a convenient sampling method. Then, answers to the questions resulted in the score (without units).ResultsA total number of 456 participants between 60 and 90 years with an average age of 64 ± 5.12 years took part in this study. The mean ± SD score of total perceived stress was 16.45 ± 8.36 (the mean score of stress was 10.30 ± 6.16 and coping was 6.15 ± 3.83). Of the total, 129 participants (28.28%) were grouped as the high‐stress group. Results showed that the 70–79 years age group had higher odds of belonging to the stressed group than the 60–69 years age group (odds ratio = 2.336). Moreover, participants with a diploma were 57% more stressed than illiterate participants. The latter perceived less stress and had lower odds of belonging to the high‐stress group. The employed were 61% less likely to be categorized in the stressed group than the unemployed. Among women, 43% were less likely than men to be in the high‐stress group.ConclusionAs the present findings showed, the risk factors of perceived stress induced by COVID‐19 are old age, low education, unemployment, and masculinity. Therefore, planning to improve stress‐coping skills such as entertainment, strengthening social relationships, physical activity, and the peace of mind of this population are suggested under the supervision of geriatric specialists and psychiatrists.
AMP‐activated protein kinase inhibition in fibro‐adipogenic progenitors impairs muscle regeneration and increases fibrosis
Authors: Liu Xiangdong , Zhao Liang , Gao Yao , Chen Yanting , Tian Qiyu , Son Jun Seok , Chae Song Ah , de Avila Jeanene Marie , Zhu Mei‐Jun , Du Min 
Published: December 2022

AbstractBackgroundFollowing muscle injury, fibro‐adipogenic progenitors (FAPs) are rapidly activated and undergo apoptosis at the resolution stage, which is required for proper muscle regeneration. When excessive FAPs remain, it contributes to fibrotic and fatty infiltration, impairing muscle recovery. Mechanisms controlling FAP apoptosis remain poorly defined. We hypothesized that AMP‐activated protein kinase (AMPK) in FAPs mediates their apoptosis during the muscle regeneration.MethodsTo test, AMPKα1fl/fl PDGFRαCre mice were used to knock out AMPKα1 in FAPs. Following AMPKα1 knockout, the mice were injected with phosphate‐buffered saline or glycerol to induce muscle injury. Tibialis anterior muscle and FAPs were collected at 3, 7 and 14 days post‐injury (dpi) for further analysis.ResultsWe found that AMPKα1 deletion in FAPs enhanced p65 translocation to the nuclei by 110% (n = 3; P < 0.01). AMPKα1 knockout group had a higher gene expression of MMP‐9 (matrix metalloproteinase‐9) by 470% (n = 3; P < 0.05) and protein level by 39% (n = 3; P < 0.05). Loss of AMPKα1 up‐regulated the active TGF‐β1 (transforming growth factor‐β1) levels by 21% (n = 3; P < 0.05). TGF‐β promoted apoptotic resistance, because AMPKα1‐deficient group had 36% lower cleaved Caspase 3 (cCAS3) content (n = 3; P < 0.05). Fibrotic differentiation of FAPs was promoted, with increased collagen protein level by 54% (n = 3; P < 0.05). Moreover, obesity decreased phosphorylation of AMPK by 54% (n = 3; P < 0.05), which decreased cCAS3 in FAPs by 44% (n = 3; P < 0.05) and elevated collagen accumulation (52%; n = 3; P < 0.05) during muscle regeneration.ConclusionsThese data suggest that AMPK is a key mediator of FAPs apoptosis, and its inhibition due to obesity results in fibrosis of regenerated muscle.
Tailored opening questions to the context of using medical questionnaires: Qualitative analysis in first‐visit consultations
Authors: Abe Tetsuya , Nishiyama Junji , Kushida Shuya , Kawashima Michie , Oishi Naoko , Ueda Kento 
Published: December 2022

AbstractBackgroundCommunication skills required for doctors do not consist of simple uses of particular linguistic forms but include uses that are sensitive to the interactional context. In consultations where the doctors have pre‐existing information about their patients, this can complicate the context of problem solicitation. We investigated how doctors tailor opening questions to a context in which they get pre‐existing information from a medical questionnaire (MQ) filled out by the patients.MethodsThe data for this study were 87 video recordings of first visits to the department of general medicine at a university hospital in Japan. We qualitatively analyzed doctors' practices in problem solicitation in an opening phase using conversation analysis and triangulated it with quantitative analysis.ResultsOpen‐ended questions accounted for 26.4% of opening questions. Among the closed‐ended questions, 75.0% were confirming questions about symptoms. In cases with open‐ended questions, doctors minimized the relevance of the MQ to problem solicitation by giving license to repeat the description from the MQ. In cases with closed‐ended questions, doctors highlighted the relevance of the MQ by sharing the MQ. Through these practices, they avoided patients' possible confusion about problem presentation while simultaneously maximizing the possibility of soliciting the patients' narratives.ConclusionsDoctors adjusted the level of relevance of pre‐existing information to problem solicitation through both verbal and nonverbal management of the MQ. It will be useful to instruct such context‐dependent practices to improve communication skills in medical school curriculum.
Production of iturin A by Bacillus velezensis ND and its biological control characteristics
Authors: Tang Zhongmin , Cao Xiaojie , Zhang Huili 
Published: December 2022

AbstractBacillus subtilis, as a biocontrol bacterium, possess a variety of biological functions and the capacity to control plant pathogens. Iturin A is a biosurfactant with broad‐spectrum antifungal activity produced by fermentation of B. subtilis. In this study, the dynamic parameters of solid‐state fermentation (SSF) and submerged fermentation (SMF) of Bacillus velezensis ND were compared, and a method for producing iturin A with a yield of 12.46 g/kg utilizing SSF was proposed. It has significant advantages over SMF and has the highest yield of all previously reported studies. B. velezensis ND also contains protease activity, cellulase activity, iron‐carrying activity, the ability to synthesis 3‐indoleacetic acid (IAA), fixation nitrogen, and degrade phosphorus. In cotton pot experiments, it can effectively increase cotton growth and minimize Verticillium wilt. This strain's superior fermentation efficiency, biological function, and biocontrol ability are sufficient to demonstrate its promise for the development and use of biocontrol agents.
Deglacial dynamics of the Foxe–Baffin Ice Sheet, Frobisher Bay, Nunavut, Canada revealed by submarine landform mapping
Authors: Todd Brian J. , Dowdeswell Julian A. , Shaw John , Campbell D. Calvin , Mate David J. 
Published: December 2022

ABSTRACTPrevious interpretation of the nature and distribution of subaerial glacial landforms established that Frobisher Bay in southeastern Baffin Island was glaciated in the Late Wisconsinan by ice flowing southeast from the Foxe–Baffin Ice Dome. New seafloor mapping within the bay has revealed submarine glacial landforms that are described and interpreted in the context of their subglacial, ice‐marginal, glaciomarine and marine process environments. Interpretation of the evidence confirms that ice occupied Frobisher Bay, flowing from the northwest to southeast, parallel to the orientation of the bay. Relatively rapid ice velocities are indicated by the presence of ice‐moulded bedrock and megaridges flanking a deep trough (>700 m) along the faulted southern flank of Frobisher Bay. In shallower regions, areal scouring and channelisation indicate the widespread presence of glacial ice. As ice retreated to the northwest towards the Foxe Ice Dome, De Geer and recessional moraines were deposited at the ice front. The latter correlate spatially with the extensive Frobisher Bay Moraine System on land. Two iceberg ploughmark populations are evident, with smaller relict features in shallow water in rare locations in the northwest of the bay, and larger relict and modern ploughmarks in deeper water in outer Frobisher Bay.
Social and financial performance of microfinance institutions and its drivers: Evidence from MENA region
Authors: Abdelkader Ines Ben 
Published: December 2022

AbstractThe paper examines the determinants of social and financial performance of microfinance institutions using a database obtained from the MIX, consisting of 79 MFIs from the MENA region. The results reveal the existence of a possible trade‐off between profitability and outreach since MFI, oriented toward female borrowers, are likely to be less profitable than others. Another interesting finding is that non‐profit non‐governmental organizations (NGO) perform better in operational self‐sufficiency than MFIs with a different legal status. Overall, the specific institutional variables and macroeconomic factors appear to be critical determinants of the social and financial performance of MFIs.
Optical characterization of curved organic light emitting diodes with different thicknesses of barrier layers and cylindrical radii of curvatures
Authors: Käläntär K. 
Published: December 2022

AbstractOrganic light emitting diode (OLED) light sources were bent to study theoretically and experimentally the effect of bending on the optical characteristics. First, the effect of superstrate thickness on the emitted light was theoretically studied for cylindrical and spherical bent OLEDs, and the transmission and the reflection coefficients were simulated. In the second step, four OLEDs were fabricated; three of them with polyethylene naphthalate (PEN) superstrates and one with glass superstrate for comparison. In the third step, three jigs were fabricated with radii of R0 = ∞ mm (plane), R2 = 143 mm (cylinder), and R5 = 56.7 mm (cylinder). The OLEDs were fixed on the jigs and the on‐axis and off‐axis spectra of each were measured. In addition, the effect of barrier thickness on the optical characteristics was studied by changing the thickness from 100 to 150 nm. The reduction in bent radius resulted in shifts of the spectra toward the shorter wavelengths, and meanwhile, the width of the spectra was reduced. Similar result was found when the barrier layer was increased; that is, the peaks of the shorter spectra increased resulting in narrow bandwidth spectra. By bending a flexible OLED, a color change acquires and it increases with the bending radius, as well as by the increase of the barrier layer thickness.
Quantitative characterization of duodenal gastrinoma autofluorescence using multiphoton microscopy
Authors: Knapp Thomas G. , Duan Suzann , Merchant Juanita L. , Sawyer Travis W. 
Published: December 2022

AbstractBackgroundDuodenal gastrinomas (DGASTs) are neuroendocrine tumors that develop in the submucosa of the duodenum and produce the hormone gastrin. Surgical resection of DGASTs is complicated by the small size of these tumors and the tendency for them to develop diffusely in the duodenum. Endoscopic mucosal resection of DGASTs is an increasingly popular method for treating this disease due to its low complication rate but suffers from poor rates of pathologically negative margins. Multiphoton microscopy can capture high‐resolution images of biological tissue with contrast generated from endogenous fluorescence (autofluorescence [AF]) through two‐photon excited fluorescence (2PEF). Second harmonic generation is another popular method of generating image contrast with multiphoton microscopy (MPM) and is a light‐scattering phenomenon that occurs predominantly from structures such as collagen in biological samples. Some molecules that contribute to AF change in abundance from processes related to the cancer disease process (e.g., metabolic changes, oxidative stress, and angiogenesis).Study Design/Materials and MethodsMPM was used to image 12 separate patient samples of formalin‐fixed and paraffin‐embedded duodenal gastrinoma slides with a second‐harmonic generation (SHG) channel and four 2PEF channels. The excitation and emission profiles of each 2PEF channel were tuned to capture signal dominated by distinct fluorophores with well‐characterized fluorescent spectra and known connections to the physiologic changes that arise in cancerous tissue.ResultsWe found that there was a significant difference in the relative abundance of signal generated in the 2PEF channels for regions of DGASTs in comparison to the neighboring tissues of the duodenum. Data generated from texture feature extraction of the MPM images were used in linear discriminant analysis models to create classifiers for tumor versus all other tissue types before and after principal component analysis (PCA). PCA improved the classifier accuracy and reduced the number of features required to achieve maximum accuracy. The linear discriminant classifier after PCA distinguished between tumor and other tissue types with an accuracy of 90.6%−93.8%.ConclusionsThese results suggest that multiphoton microscopy 2PEF and SHG imaging is a promising label‐free method for discriminating between DGASTs and normal duodenal tissue which has implications for future applications of in vivo assessment of resection margins with endoscopic MPM.
Quality assurance assessment of intra‐acquisition diffusion‐weighted and T2‐weighted magnetic resonance imaging registration and contour propagation for head and neck cancer radiotherapy
Authors: Naser Mohamed A. , Wahid Kareem A. , Ahmed Sara , Salama Vivian , Dede Cem , Edwards Benjamin W. , Lin Ruitao , McDonald Brigid , Salzillo Travis C. , He Renjie , Ding Yao , Abdelaal Moamen Abobakr , Thill Daniel , O'Connell Nicolette , Willcut Virgil , Christodouleas John P. , Lai Stephen Y. , Fuller Clifton D. , Mohamed Abdallah S. R. 
Published: December 2022

AbstractBackground/PurposeAdequate image registration of anatomical and functional magnetic resonance imaging (MRI) scans is necessary for MR‐guided head and neck cancer (HNC) adaptive radiotherapy planning. Despite the quantitative capabilities of diffusion‐weighted imaging (DWI) MRI for treatment plan adaptation, geometric distortion remains a considerable limitation. Therefore, we systematically investigated various deformable image registration (DIR) methods to co‐register DWI and T2‐weighted (T2W) images.Materials/MethodsWe compared three commercial (ADMIRE, Velocity, Raystation) and three open‐source (Elastix with default settings [Elastix Default], Elastix with parameter set 23 [Elastix 23], Demons) post‐acquisition DIR methods applied to T2W and DWI MRI images acquired during the same imaging session in twenty immobilized HNC patients. In addition, we used the non‐registered images (None) as a control comparator. Ground‐truth segmentations of radiotherapy structures (tumour and organs at risk) were generated by a physician expert on both image sequences. For each registration approach, structures were propagated from T2W to DWI images. These propagated structures were then compared with ground‐truth DWI structures using the Dice similarity coefficient and mean surface distance.Results19 left submandibular glands, 18 right submandibular glands, 20 left parotid glands, 20 right parotid glands, 20 spinal cords, and 12 tumours were delineated. Most DIR methods took <30 s to execute per case, with the exception of Elastix 23 which took ∼458 s to execute per case. ADMIRE and Elastix 23 demonstrated improved performance over None for all metrics and structures (Bonferroni‐corrected p < 0.05), while the other methods did not. Moreover, ADMIRE and Elastix 23 significantly improved performance in individual and pooled analysis compared to all other methods.ConclusionsThe ADMIRE DIR method offers improved geometric performance with reasonable execution time so should be favoured for registering T2W and DWI images acquired during the same scan session in HNC patients. These results are important to ensure the appropriate selection of registration strategies for MR‐guided radiotherapy.