bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with poor academic performance among undergraduate dental students: A cross‐sectional study
Authors: Fernandez Matheus dos Santos , Pontes Ana Flávia Leite , Casarin Maísa , Feijo Juliana dos Santos , Pola Natália Marcumini , Muniz Francisco Wilker Mustafa Gomes 
Published: November 2022

AbstractObjectiveTo evaluate the factors associated with poor academic performance among undergraduate dental students enrolled at a public university in Brazil.MethodsA semi‐structured questionnaire addressing the exploratory variables of interest (sociodemographic and economic characteristics, use of medications and drugs, dentistry as the first choice of undergraduate course, and the Pittsburgh Sleep Quality Index) was hosted on Google Forms and shared with all dental students at the Federal University of Pelotas. Academic performance was evaluated based on institutional records, access to which the participants had previously authorized; students with good (average ≥7.0 points) or poor academic performance (average <7.0 points) were considered. Adjusted logistic regressions were performed to verify the association between academic performance and the exploratory variables (p < 0.05).ResultsIn total, 244 students were included, of whom 18.8% had poor academic performance. Increased age (OR: 1.34; 95%CI: 1.18–1.52), non‐white skin color (OR: 1.34; 95%CI: 1.18–1.52), the use of medications for anxiety and depression (OR: 1.34; 95%CI: 1.18–1.52), and poor sleep quality (OR: 1.34; 95%CI: 1.18–1.52) were factors associated with poor academic performance.ConclusionA low prevalence of poor academic performance was observed. Non‐white skin color, increased age, use of anxiolytics or antidepressants, and poor or disturbed sleep may reduce dental students’ academic performance.
Inositol 1,4,5‐trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population
Authors: Chen Jiaping , Zhou Jing , Jiang Yue , Wang Yuzhuo , Chen Congcong , Jiang Tao , Du Jiangbo 
Published: November 2022

AbstractBackgroundMammalian inositol 1,4,5‐trisphosphate receptor (ITPR) genes encode ubiquitously expressed endoplasmic reticulum Ca2+ channels that have recently been shown to be closely linked to the pathogenesis of several cancers. However, few studies to date have explored associations between ITPR gene family single nucleotide polymorphisms (SNPs) and breast cancer risk.MethodsIn the present case–control study, 12 SNPs in the potential functional regions of the ITPR1, ITPR2, and ITPR3 genes were genotyped using an Illumina Infinium® Beadchip in 2095 Chinese women (1032 cases and 1063 controls).ResultsMultivariate logistic regression analyses indicated that a missense SNP in the ITPR3 coding region (rs2229642) was significantly related to breast cancer risk when using an additive model in this study (rs2229642‐adjusted odds ratio = 1.40, 95% confidence interval = 1.12–1.74, p = 2.97 × 10−3). Expression quantitative trait loci analyses indicated that the SNP rs2229642 was associated with reduced ITPR3 expression levels (p = 3.2 × 10−7) and with marked reductions in the expressions of several proximal genes, including BAK1, GRM4, HLA‐DOB, and UQCC2 (p = 0.013, 0.018, 3.4 × 10−3, 3.8 × 10−5), suggesting that it may further regulate other genes associated with oncogenic susceptibility. Kaplan–Meier analyses indicated that the patients with higher ITPR3 expression exhibited significantly poorer outcomes compared to the patients with lower expression of this gene (hazard ratio = 1.11, 95% confidence interval = 1–1.23, p = 0.046).ConclusionsThe results indicated that genetic variant in the coding region of ITPR3 gene may regulate the expressions of its host and some other cancer‐related genes, as well as act as potential predictive biomarker for susceptibility to breast cancer in the Chinese population.
Pre‐emptive hydration with lactated Ringer's solution could reduce the incidence of post‐endoscopic retrograde cholangiopancreatography pancreatitis in at‐risk patients: Propensity score‐matched analysis
Authors: Kurita Yusuke , Suzuki Ko , Yagi Shin , Hasegawa Sho , Sato Takamitsu , Hosono Kunihiro , Kobayashi Noritoshi , Endo Itaru , Kubota Kensuke , Nakajima Atsushi 
Published: November 2022

AbstractBackground/PurposeThis study aimed to investigate the efficacy of intensive fluid‐loading therapy post‐endoscopic retrograde cholangiopancreatography (ERCP) for the prevention of post‐ERCP pancreatitis (PEP) in at‐risk patients.MethodsIn this retrospective study, data of 1200 patients at risk for PEP were investigated. After propensity score matching, 404 patients were included in the normal (n = 202) and hydration (n = 202) groups. On the day of ERCP, patients in both groups were infused with 2000 ml/24 h of fluid before ERCP. Meanwhile, the hydration group received an additional 1000 ml/10 h of lactated Ringer's solution postoperatively.ResultsThe incidence of PEP was lower in the hydration group (12.4%) than in the normal group (24.3%) (odds ratio [OR]: 0.44; 95% CI: 0.26–0.75, p = .003). The incidence of severe PEP was 2.0% and 6.9% in the hydration and normal groups (OR: 0.27; 95% CI: 0.09–0.84, p = .027), respectively. The incidence of fatal PEP was 0% and 2.0% in the hydration and normal groups (OR: N.A.: p = .123), respectively.ConclusionsPost‐ERCP hydration may be an effective method of preventing PEP, including severe PEP, in at‐risk patients.
Bias in the background? The role of background information in asynchronous video interviews
Authors: Roulin Nicolas , Lukacik Eden‐Raye , Bourdage Joshua S. , Clow Lindsey , Bakour Hayam , Diaz Pedro 
Published: November 2022

SummaryAsynchronous video interviews (AVIs) have become popular tools for applicant selection. Although AVIs are standardized, extant research remains silent on whether this novel interview format could introduce new forms of bias. Because many applicants complete AVIs from their homes, their video background could provide evaluators with information about stigmatizing features that (a) are usually “invisible” in traditional selection contexts but become observable in AVIs, (b) are not always legally protected, and (c) can impact evaluators' judgments. Across three experimental studies, we examined how cues indicating parental status (Study 1), sexual orientation (Study 2), and political affiliation (Study 3) can impact perceptions of applicant warmth and competence and ratings of interview performance and potential work performance. The effect of background information varied by stigmatized feature. Applicants depicted as parents were perceived to be higher on warmth and received higher interview performance ratings but were not evaluated more negatively on competence or potential work performance. There was no effect of sexual orientation on any outcome variables. However, applicants who supported the same political party as the evaluator were viewed as warmer and received higher ratings of interview performance and potential work performance. Thus, organizations should encourage applicants to use neutral backgrounds.
Correlation between microbial communities and key odourants in fermented capsicum inoculated with Pediococcus pentosaceus and Cyberlindnera rhodanensis
Authors: Shi Qiao , Tang Xin , Liu Bi‐Qin , Liu Wei‐Hong , Li Hong , Luo Yi‐Yong 
Published: November 2022

AbstractBACKGROUNDFermented capsicum (i.e. pickled pepper) is one of the most popular fermented vegetables. However, the effect of inoculated microbial fermentation on pickled pepper is not yet fully understood.RESULTSCyberlindnera rhodanensis J52 with a rich ester flavour and Pediococcus pentosaceus AL with a strong inhibitory effect on foodborne pathogenic bacteria were selected to prepare single‐ and double‐strain fermented capsicum under low salt (< 10 g L−1 sodium chloride) conditions. The inhibition zone of P. pentosaceus AL against Escherichia coli was up to 44 mm in diameter. Biochemical indicator analyses found that co‐fermentation of P. pentosaceus AL and C. rhodanensis J52 changed the contents of vitamin C and short‐chain fatty acids. Analysis of microbial diversity and volatile metabolome showed that 125 microbial species and 72 volatile compounds were detected, and P. pentosaceus was the dominant bacterium that inhibited the growth of other bacteria, while C. rhodanensis was the fungus that contributed the most to flavour. Correlation analysis between microorganisms and flavour compounds showed 725 correlations, and 124 microbial species may have participated in the formation of 69 compounds. Furthermore, 10 and 29 correlations were detected between P. pentosaceus AL or C. rhodanensis J52 and flavour compounds, respectively. Among them, 3‐methyl‐1‐butanol acetate is speculated to be the main substance affecting the flavour of fermented capsicum by inoculation with C. rhodanensis J52.CONCLUSIONThe inoculation of P. pentosaceus and C. rhodanensis had a significant impact on the microbial community and volatile compounds of fermented capsicum and helped to improve its organoleptic qualities. © 2022 Society of Chemical Industry.
Determination of 35 sulfonamides in pork by magnetic molecularly imprinted polymer‐based dispersive solid‐phase extraction and ultra‐performance liquid chromatography photodiode array method
Authors: Wang Su Han , Wang Jian Ping , Wu Ning Peng 
Published: November 2022

AbstractBACKGROUNDSulfonamide residues in foods of animal origin are potential risks to consumer health, so it is very important to inspect them. Among the previously reported instrumental methods, the best method can only be used to determine at most 22 sulfonamides. Thus, an instrumental method capable of determining more sulfonamide species is desirable.RESULTSIn this study, sulfadoxine was used as a template to synthesize a type of magnetic molecularly imprinted polymer that could recognize 35 sulfonamides. After characterization, this composite was used to develop a dispersive solid‐phase extraction method for extraction and purification of the 35 sulfonamides in pork, followed by determination using an ultra‐performance liquid chromatography photodiode array method. This composite exhibited high adsorption capacity (11.01–19.21 μg mg−1) and high recovery (>89.01%), and could be reused at least ten times. Due to the enrichment effect during sample preparation (enrichment factor 22–66), the limits of detection for determination of the 35 drugs in pork were in the range of 0.08–0.53 ng g−1. The detection results for some real pork samples were consistent with a liquid chromatographic–tandem mass spectrometric method. After comparison, the present method showed generally better performances than the previously reported sample preparation methods and instrumental methods for detection of sulfonamides.CONCLUSIONThe method developed in the present study could be used as a practical tool for routine detection of sulfonamide residues in pork samples. © 2022 Society of Chemical Industry.
Rehmannia glutinosa polysaccharides attenuates colitis via reshaping gut microbiota and short‐chain fatty acid production
Authors: Lv Hao , Jia Hongpeng , Cai Wenjie , Cao Rujing , Xue Chenyu , Dong Na 
Published: November 2022

AbstractBACKGROUNDUlcerative colitis is a gastrointestinal disease closely related to intestinal epithelial barrier damage and intestinal microbiome imbalance; however, effective treatment methods are currently limited. Rehmannia glutinosa polysaccharide (RGP) is an important active ingredient with a wide range of pharmacological activities, although its protective effect on colitis remains to be explored. In the present study, we verified the in vitro anti‐inflammatory effect of RGP, and observed the ameliorating effect of RGP on dextran sulfate sodium‐induced colitis in mice.RESULTSThe results showed that (i) RGP attenuates lipopolysaccharide‐induced overexpression of inflammatory factors in RAW264.7 cells; (ii) RGP improves the pathological damage caused by DSS, including weight loss, increased disease activity index and intestinal tissue ulcers; (iii) RGP improves tight junction proteins to protects the tightness of the intestinal epithelium; (iv) RGP inhibits the expression of inflammatory factors through the nuclear factor‐kappa B pathway, and improved the of intestinal tissues inflammation; and (v) RGP can maintain the species diversity of intestinal microbes, increase the content of short‐chain fatty acids and then restore the imbalance of intestinal microecology.CONCLUSIONRGP can improve the intestinal microbiota to strengthen the intestinal epithelial barrier and protect against DSS‐induced colitis. © 2022 Society of Chemical Industry.
A total neoadjuvant chemotherapy approach is associated with improved recurrence‐free survival in patients with colorectal peritoneal metastases undergoing cytoreductive surgery and HIPEC
Authors: Hanna David N. , Macfie Rebekah , Ghani Muhammad O. , Hermina Andrew , Mina Alexander , Cha Da Eun , Bailey Christina E. , Cohen Noah , Labow Daniel , Golas Benjamin , Sarpel Umut , Magge Deepa , Idrees Kamran 
Published: November 2022

AbstractBackgroundThe primary aim of this study is to evaluate the oncologic outcomes of two popular systemic chemotherapy approaches in patients with colorectal peritoneal metastases (CPM) undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS‐HIPEC).MethodsWe performed a dual‐center retrospective review of consecutive patients who underwent CRS‐HIPEC for CPM due to high or intermediate‐grade colorectal cancer. Patients in the total neoadjuvant therapy (TNT) group received 6 months of preoperative chemotherapy. Patients in the “sandwich” (SAND) chemotherapy group received 3 months of preoperative chemotherapy with a maximum of 3 months of postoperative chemotherapy.ResultsA total of 34 (43%) patients were included in the TNT group and 45 (57%) patients in the SAND group. The median overall survival (OS) in the TNT and SAND groups were 77 and 61 months, respectively (p = 0.8). Patients in the TNT group had significantly longer recurrence‐free survival (RFS) than the SAND group (29 vs. 12 months, p = 0.02). In a multivariable analysis, the TNT approach was independently associated with improved RFS.ConclusionIn this retrospective study, a TNT approach was associated with improved RFS, but not OS when compared with a SAND approach. Further prospective studies are needed to examine these systemic chemotherapeutic approaches in patients with CPM undergoing CRS‐HIPEC.
Tubs, tanks, and towers: Donor strategies for donor‐advised funds giving
Authors: Heist H. Daniel , Cummings Benjamin F. , Farwell Megan M. , Cnaan Ram , Andrews Erinn 
Published: November 2022

AbstractThe increasing use of donor‐advised funds (DAFs) creates challenges for nonprofit managers and fundamentally changes the way that many donors give to charity. We conducted 48 in‐depth interviews with DAF donors to understand their strategies of how they give through a DAF. From the interviews, we found three distinct models of DAF giving strategies: tubs, tanks, and towers. Tub donors give quickly through a DAF, moving money in and out annually. Tank donors contribute large lump sums and grant the money away in the relatively near future. Tower donors take a calculated approach with the DAF to sustain their philanthropic activity over time. Several factors relate to these strategies, including the sources and timing of contributions, different purposes of grantmaking, tax implications, investment strategies, and family involvement. Our findings may help nonprofit managers, fundraisers, and other stakeholders to better understand the various ways donors give through DAFs.
Ocular survival after intra‐arterial chemotherapy for retinoblastoma improves with accrual of experience and programmatic evolution
Authors: Marasligiller Stefan A. , Williams Basil K. , Vadivelu Sudhakar , Correa Zelia M. , Abruzzo Todd A. , Nicola Maura Di , Lane Adam , Geller James I. 
Published: November 2022

AbstractBackgroundIntra‐arterial chemotherapy (IAC) for the treatment of intraocular retinoblastoma has gained recognition as a method to improve ocular salvage; however, there is a paucity of evidence supporting treatment factors prognosticating ocular survival.MethodsAll patients with retinoblastoma treated with IAC at a single institution between December 2008 and December 2019 were evaluated. Patient demographics, tumor classification, prior treatments, procedural data, other non‐IAC therapies, adverse reactions, procedural complications, ocular outcomes, and overall survival were assessed via retrospective chart review. Factors suggestive of increased ocular survival were identified via univariate and multivariate analyses. The impact of accrued treatment experience was evaluated by grouping eyes by the respective year, IAC treatment was initiated.ResultsForty‐nine eyes of 43 patients were treated for retinoblastoma with IAC (256 total procedures). At least grade 3 neutropenia was observed following 19% of IAC procedures. The risk of neutropenia was not statistically different between single or multidrug IAC. Comparing those who received balloon‐assisted intra‐arterial chemotherapy (bIAC) in more than two‐thirds of cycles to those who did not, the risk of arterial access site complications was not statistically different. Multivariate analysis revealed a significantly lower risk of enucleation associated with treatment era in years (hazard ratio [HR] = 0.52–1.00, p < .05) and laser therapies (HR = 0.02–0.60, p < .05).ConclusionsOcular survival rates in patients treated with IAC for retinoblastoma at our institution have increased over time. Accrued treatment experience and programmatic changes have likely contributed. Larger, prospective series may lead to a better understanding of factors that consistently contribute to better ocular salvage.
Comparison of catheter‐related bloodstream infection rates in pediatric patients receiving parenteral nutrition with soybean oil‐based intravenous fat emulsion versus a mixed oil fat emulsion
Authors: Alvira‐Arill Gustavo R. , Herrera Oscar R. , Tsang Chi Chun Steve , Wang Junling , Peters Brian M. , Stultz Jeremy S. 
Published: November 2022

AbstractStudy ObjectiveTo compare rates of catheter‐related bloodstream infections (CR‐BSI) in pediatric patients who received parenteral nutrition (PN) with either soybean oil‐based intravenous fat emulsion (SO‐IFE) or mixed oil‐IFE (MO‐IFE). We hypothesized that the use of MO‐IFE would be independently associated with reduced infection rates compared with SO‐IFE.DesignRetrospective cohort study.SettingTertiary referral children's hospital and its associated gastrointestinal rehabilitation clinic (01 January, 2015–31 July, 2019).PatientsDays of IFE exposure were counted for patients aged <18 years on IFE initiated during the review period, who had a central venous catheter (CVC) placed for PN administration, received IFE at least three times weekly, and for at least 7 days.MeasurementsThe primary outcome included total and categorical CR‐BSI rates expressed as the average with standard error (SE) number of infections per 1000 fat emulsion days. The following categories were specified: Candida albicans, non‐albicans Candida spp., coagulase‐negative Staphylococcus (CoNS), Enterobacterales, methicillin‐resistant S. aureus, methicillin‐susceptible S. aureus, and Pseudomonadales. Average infection rate comparisons were quantified as incidence rate ratios (IRR) using generalized linear mixed modeling with a Poisson distribution.Main ResultsSeven hundred and forty‐three SO‐IFE and 450 MO‐IFE exposures were reviewed from 1131 patients, totaling 37,599 and 19,796 days of therapy, respectively. From those found significantly different, the average rate of infections with CoNS was 3.58 (SE 0.5)/1000 days of SO‐IFE and 1.39 (SE 0.45)/1000 days of MO‐IFE (IRR [95% confidence interval, CI]: 0.27 [0.16–0.46]; p < 0.01). Total average rates of infection were 7.33 (SE 0.76)/1000 days of SO‐IFE and 4.52 (SE 0.75)/1000 days of MO‐IFE (IRR [95% CI]: 0.60 [0.44–0.81]; p < 0.01). Other factors associated with higher infection rates include female gender, neonatal age, and inpatient‐only IFE exposure.ConclusionsReceipt of MO‐IFE was associated with lower rates of CoNS and total CR‐BSIs compared with SO‐IFE in pediatric patients. These findings could have major implications on IFE selection for pediatric patients receiving PN.
Ineffectiveness of applying additional insecticide sprays at the border of the citrus block for the control of Huanglongbing
Authors: Vescove Primiano Isabela , Parra Asato Fabiano , Beozzo Bassanezi Renato 
Published: November 2022

AbstractBackgroundHuanglongbing (HLB), mainly associated with the bacterium ‘Candidatus Liberibacter asiaticus’, is a devastating disease that causes negative impacts on citrus yield and fruit quality. One of the main HLB control measures is based on preventive insecticide sprays, aiming to control its vector, the Asian citrus psyllid (ACP) Diaphorina citri. In blocks on the orchard's periphery, the ACP population is more concentrated in trees closer to the block's edge and gradually decreasing towards its interior. This spread pattern of ACP has motivated growers to perform, empirically based, additional insecticide applications at the border of the block (‘AB’), as an additional measure to spraying insecticides in the entire block (‘EB’). Hence, this work aimed (i) to evaluate the coverage and efficiency of AB, comparing tree canopy volume, and planting direction; and (ii) to compare ACP population and HLB incidence between blocks treated under EB, and blocks that received ‘EB + AB’.ResultsRegardless of the operational situation, as the distance increased from the orchard's edge (0 m) to the interior, spray coverage exponentially decayed from an average of 21% to less than 1% of coverage, and ACP mortality exponentially decayed from 83% to 7%. In general, the spray coverage and ACP mortality were suitable only for the tree canopy face directly sprayed at the orchard's edge (0 m). After 5.5 years, a higher ACP population and number of symptomatic trees were detected in ‘EB + AB’.ConclusionAs the ‘EB + AB’ had no effect in reducing ACP population, or HLB incidence, this additional spraying had no benefit in HLB management. © 2022 Society of Chemical Industry.