bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sistem Informasi Pengarsipan Surat Berbasis Website Pada Kantor Camat Lambu Kabupaten Bima
Authors: Rezki Ayu , Wijaya I Gede Pasek Suta , Akbar Sulfan 
Published: October 2022

Pengelolaan arsip pada Kantor Camat Lambu masih dilakukan secara manual, padahal Kantor Camat Lambu memiliki cukup banyak data dalam hal pengarsipan surat, baik surat masuk maupun surat keluar. Kegiatan pengarsipan secara manual dapat menyebabkan terjadinya kesalahan dalam penyimpanan dan pencarian data arsip. Arsip merupakan dokumen penting yang disimpan dengan tujuan apabila dibutuhkan kembali akan mudah untuk menemukannya, maka sangat diharapkan proses pengelolaan arsip dilakukan dengan baik, cepat, dan mudah dengan memanfaatkan teknologi yang ada saat ini. Oleh karena itu sistem informasi pengarsipan surat berbasis website menggunakan framework Bootstrap ini dibuat dengan tujuan untuk mengubah cara pengelolaan dan pengarsipan data arsip yang semula hard copy menjadi soft copy. Metode yang digunakan dalam pembuatan sistem yaitu metode waterfall dengan urutan tahapan dari Analisa kebutuhan perangkat lunak (Requirements Analysis), Desain (Design), Pembuatan kode program (Coding), Pengujian (Testing), dan Pemeliharaan (Maintenance). Pengujian sistem dilakukan dengan menggunakan user acceptance testing yang di dalamnya terdapat pengujian black box dan kuisioner kemudian didapatkan hasil bahwa responden yang merupakan pegawai Kantor Camat setuju dengan sistem yang dibuat dengan kepuasaan terhadap sistem yang dibuat 100% sesuai dengan kebutuhan, fungsi, kinerja, dan informasi yang dihasilkan.
Screening Method Synthesis of AgNPs Using Petroselinum crispum (parsley) Leaf: Spectral Analysis of the Particles and Antibacterial Study
Authors: Alshahrani Shadia Hamoud , Alameri Ameer A. , Zabibah Rahman S. , Jalil Abduladheem Turki Jalil , Ahmadi Omid , Behbudi Gity 
Published: October 2022

Abstract. The synthesis and applications of nanomaterials are an excitingand emerging field of scientific research. In this paper, silver nanoparticles (AgNPs) were synthesized using parsley leaf extract via the screening method (autoclave hydrothermal heating, and heater), and their microbial activities were studied. An extract of chopped parsley leaves was prepared. AgNO3 salt with a concentration of 1 mM was used. In every two methods of autoclave hydrothermal heating and heater, 5 mL of the Parsley leaf extract was mixed with 25 mL of silver nitrate salt. By FTIR analysis, the presence of Petroselinum crispum (parsley) leaf extract in NPs was identified. By using a hydrothermal autoclave and heater to synthesize AgNPs at the lowest wavelength, the size of NPs was achieved at 403 nm and 414 nm, respectively. All samples synthesized by different techniques had suitable zeta potential and acceptable stability. By giving the zeta potential of NPs synthesized by autoclave (-14.3 mV), results showed that this method is suitable for the production of AgNPs. Comparing the antibacterial attributes of the synthesized Ag NPs by different techniques (autoclave and heater) on Gram-negative bacteria (E. coli) showed 16±1, and 12±1, respectively.

Resumen. La síntesis y las aplicaciones de los nanomateriales son un campo de investigación científica emocionante y emergente. En esta investigación, se sintetizaron nanopartículas de plata (AgNP) utilizando extracto de hoja de perejil a través del método de selección (calentamiento hidrotermal en autoclave y calentador), y se estudiaron sus actividades microbianas. Se preparó un extracto de hojas de perejil picadas. Se utilizó AgNO3 a una concentración de 1 mM y se utilizaron los métodos de calentamiento en autoclave y calentador; se mezclaron 5 mL del extracto de hoja de Perejil con 25 mL de sal de nitrato de plata. Mediante análisis FTIR se identificó la presencia de extracto de hoja de Petroselinum crispum (perejil) en NPs. El tamaño de las NP se logró a 403 nm y 414 nm, con los métodos de calentamiento en autoclave y calentador, respectivamente. Todas las muestras sintetizadas por diferentes técnicas tuvieron un potencial zeta adecuado y una estabilidad aceptable. Al dar el potencial zeta de las NP sintetizadas en autoclave (-14,3 mV), los resultados mostraron que este método es adecuado para la producción de AgNP. La comparación de los atributos antibacterianos de las AgNP sintetizadas por diferentes técnicas (autoclave y calentador) en bacterias Gram-negativas (Escherichia coli) dieron 16±1 y 12±1, respectivamente.
Potential Compounds Interacting in a Specific Potential Site in SARS-CoV-2 Variants, Selected by Molecular Docking
Authors: Benítez-Cardoza Claudia Guadalupe , Ramirez-Torres Jesús Néstor , Vique-Sánchez José Luis 
Published: October 2022

Abstract. The SARS-CoV-2 virus continues developing variants, and different ways of treatments have been proposed during this COVID-19 pandemic. This study proposes compounds to develop a drug against SARS-CoV-2 variants, by molecular docking using a library of compounds (502530 compounds) directed to interact in the region between the amino acids (Ser477, Lys478, Pro479, Cys480, Asn481, Gly482, Val483, Lys484, Gly485, Phe486, Asn487, Cys488, and Tyr489) in the RBD in S-Protein of SARS-CoV-2, this is a specific potential site in SARS-CoV-2 variants.
We propose ten compounds selected by molecular docking, with a high probability to interact in the specific region in the RBD of SARS-CoV-2 variants (amino acids between 478 and 484), to reduce the interaction between S-protein and ACE2. Also, these compounds have a high probability to be safe in humans, validated by web servers of prediction of ADME and toxicity (PreADMET) to develop a new specific adjuvant antiviral against SARS-CoV-2 variants.

Resumen. El virus SARS-CoV-2 continúa desarrollando variantes y se han propuesto diferentes formas de tratamiento durante esta pandemia de COVID-19. Este estudio propone compuestos para desarrollar un fármaco contra las variantes del SARS-CoV-2, mediante simulaciones de acoplamiento molecular (docking) utilizando una quimioteca de compuestos (502530 compuestos) dirigidos a interactuar en la región entre los aminoácidos (Ser477, Lys478, Pro479, Cys480, Asn481, Gly482, Val483, Lys484, Gly485, Phe486, Asn487, Cys488 y Tyr489) en la RBD en la proteína S del SARS-CoV-2, este es un sitio potencial específico en las variantes del SARS-CoV-2.
Proponemos diez compuestos seleccionados por docking, con una alta probabilidad de interactuar en la región específica en la RBD de las variantes del SARS-CoV-2 (aminoácidos entre 478 y 484), para reducir la interacción entre la proteína S y ACE2. Además, estos compuestos tienen una alta probabilidad de ser seguros en humanos, validados por servidores web de predicción de ADME y toxicidad (PreADMET) para desarrollar un nuevo antiviral adyuvante específico contra variantes del SARS-CoV-2.
معوقات تمكين المرأة العراقية لممارسة الدور القيادي بالمؤسسات المجتمعية
Authors: احمد ثامر خيون صبير السعدون م. , غزوان عدي عطشان د. 
Published: October 2022

تكمن مشكلة البحث في الحاجة الوقوف على المعوقات والصعوبات التي تواجه النساء في الوصول الى المواقع القيادية في المجتمع من وجهة نظرهن، وأن قضية التمكين للمرأة تزداد بشكل واضح في ظل بعض المجتمعات التي تحصر دور المرأة في الإنجاب، وإدارة شؤون المنزل. وتزداد المشكلة تعقيداً خاصة في ظل أن القانون العراقي الذي لايساوي بين الرجل والمرأة في الحقوق والواجبات. وتاتي أهمية البحث من أهمية الدور الذي تقوم به المرأة في المؤسسة ودورها الحيوي في تطور المجتمع، و تهدفت الدراسة الحالية الى معرفة معوقات تمكين المرأة العراقية لممارسة الدور القيادي بالمؤسسات المجتمعية, وما هو الدور المطلوب منها في ظل المتغيرات المجتمعية والسياسية والاقتصادية خاصة وان المرأة اليوم باتت تشكل نسبة كبيرة في المجتمع ، تكاد تتجاوز نصف المجتمع ، مما يتطلب الاهتمام الجدي بالدور الذي ينبغي القيام به من اجل تنمية وتطوير المجتمع من خلال تطوير مهارات وقابليات المرأة المتعلمة في كافة ميادين الحياة الاجتماعية والعملية ، ثم معرفة اهم الاستنتاجات التي تم التوصل اليها من خلال هذه المقاربة التحليلية والاجتماعية .
हाम्रो निर्वाचन प्रणाली र सुधारका सम्भावनाहरू {Our electoral system and prospects for reform}
Authors: Paudel Madhav 
Published: October 2022

निर्वाचन प्रणाली लोकतन्त्रको आधार स्तम्भ हो l निर्वाचनको आवधिक अभ्यासमार्फत नागरिकले सार्वभौम अधिकारको प्रयोग गर्ने अवसर प्राप्त गर्छन्, संवैधानिक विकासले गतिशीलता प्राप्त गर्दछ र मुलुकको शासनले वैधानिकता प्राप्त गर्दछ । आवधिक निर्वाचनको अभ्यासबाट लोकतन्त्र जीवन्त हुन्छ । यस अर्थमा निर्वाचन लोकतन्त्रको प्राण वायु हो । विश्वमा विभिन्न प्रकृतिका निर्वाचन प्रणाली पाइन्छन् तापनि तिनले अङ्गीकार गरेका सारतत्व र आधारभूत मान्यता शाश्वत र विश्वव्यापी प्रकृतिका छन् l सम्बन्धित मुलुकको संवैधानिक संरचना, राजनैतिक शक्ति सन्तुलन र ऐतिहासिक परम्परा अनुसार विकसित हुने भए पनि आम रूपमा निर्वाचन प्रणालीहरू तीन प्रकारका पाइन्छन् - पहिलो हुने निर्वाचित हुने प्रणाली, समानुपातिक प्रतिनिधित्वको प्रणाली तथा मिश्रित प्रणाली । नेपालमा अन्तरिम संविधानबमोजिम गठन भएको संविधान सभाको प्रयोजनका लागि तत्काल कायम रहेको द्वन्द्व व्यवस्थापन तथा मुलुकका सबै जात, जाति, समुदायको प्रतिनिधित्व सुनिश्चित गर्न समानुपातिक प्रतिनिधित्वलाई बढी भार दिई समानुपातिक प्रतिनिधित्व र पहिलो हुने निर्वाचित हुने समानान्तर मिश्रित निर्वाचन प्रणाली अपनाइएको थियो । त्यस यता, नेपालले अपनाएको निर्वाचन प्रणाली आफ्नै विशिष्टतासहितको मिश्रित छ । यो सैद्धान्तिक रूपमा सरल देखिन्छ l तर कानुनी, प्रक्रियागत, मत भार तथा क्लष्टर व्यवस्थापनको दृष्टिले अत्यन्त जटिल झन्झटिलो छ । यो प्रणालीअन्तर्गत सबै तह र संरचनाको पहिलो निर्वाचन सम्पन्न भई स्थानीय तहको दोस्रो कार्यकालका लागि पनि निर्वाचन भइसकेको छ l अन्य जनप्रतिनिधि संस्थाको निर्वाचन हुने अवस्था छ । यो अवधिमा निर्वाचन प्रणालीका सबल पक्ष र कमजोर पक्षको पहिचान भइसकेको छ l सुधार गर्नुपर्ने विषय स्पष्ट भएका छन् । यो सिकाइ र अनुभवको आधारमा निर्वाचन प्रणालीको नियमित सुधार गर्नु प्रत्येक लोकतान्त्रिक मुलुकको राष्ट्रिय एजेन्डा हुनु पर्दछ ।
Abstract in English An electoral system is the foundation of democracy. Its periodic exercise enables citizens to realize their sovereign rights, enhances the legitimacy of governance and helps democracy to remain healthy from within. The design of a country’s electoral system depends on its constitutional arrangement, political power balance and historical tradition. It is also expected to embrace certain norms being practised universally. Among prominent electoral systems in the world are the first-past-the- post system, the proportional representation system and the mixed electoral system. Nepal has pursued the mixed electoral system, which in principle is simple and straight. However, it is very complex in terms of legal and procedural management. Following the completion of a round of elections to all levels and structures, the second round of local elections has also been completed. Preparations are on for the election to other representative bodies, including the Federal Parliament. In the process, electoral authorities have come across ample evidence of what works, what does not and where changes are needed. These lessons and experiences should drive the periodic reform of the electoral system in order to reinvigorate the democratic exercise.
Trends in Disinvestment of Government’s Equity: An Explicatory Study of Public Sector Enterprises in India
Authors: Ghosh Sudipta , Aithal P.S. 
Published: October 2022

A Public Sector Enterprise (PSE) is an enterprise which is owned and proscribed by the Local, or State or Central Govt. In a civic enterprise, the investment is either entirely or partially made by the Govt. Under PSEs, the Central Public Sector Enterprises (CPSEs) occupy an important position in the economy. They were set up to achieve fiscal development, self-support in manufacturing, intemperance equilibrium of expenditure, and controlling the deflationary and inflationary trends. These macro-economic objectives are taken as an instrument for structural change of the nation with equality and social fairness. Disinvestment is a process in which the Govt. equity fund is introverted either in fraction or in totality. The Govt. of India introduced the process of disinvesting its equity shares in Indian PSEs in the fiscal year 1991-92. The prime tenet at the back of disinvestment is to boost prosperity, endorse public partaking at wider scale and to bring improved market answerability. In this backdrop, the present study is an attempt to analyze the trends in disinvestment of Government’s equity in Indian PSEs during the period 1991-92 to 2019-20. For this purpose, secondary information has been sourced from the available yearly reports of the Public Enterprises Survey, Govt. of India. Overall, a low level of disinvestment is observed during the initial years (i.e., up to 2008-09). Thereafter, more or less an increasing trend is observed in actual disinvestment as compared to actual disinvestment in the earlier years. The real proceeds from disinvestment have fluctuated at certain point of time during the period under study. Furthermore, actual receipts from disinvestment are less than that of the budgeted receipts in most of the years under study.
Focal cortical dysplasia pathology: diagnostic difficulty, classification, and utility for pathogenesis
Authors: Kapar Ozge , Gurkan Zahide Mail , Dolgun Muge , Sencer Altay , Gürses Candan , Bilgic Bilge 
Published: October 2022

OBJECTIVE
In the histopathological examination of treatment-resistant epilepsy, focal cortical dysplasia (FCD) is the most common diagnosis in the pediatric group. FCD is classified histopathologically according to the International League Against Epilepsy (ILAE) classification. In the last decade since the ILAE classification has been released, molecular genetic studies have revealed mTOR pathway–related mutations as a major etiology. The objective of this study was to determine the incidence of FCD in treatment-resistant epilepsy patients, explore histomorphological and immunohistochemical features, examine clinicopathological correlation, demonstrate mTOR pathway activation using a pS6 antibody immunohistochemically, and try to introduce a candidate for possible targeted therapies.

METHODS
Paraffin blocks and slides of tissue from patients with treatment-resistant epilepsy were reexamined retrospectively. Histopathological subtypes of FCD were determined according to the ILAE classification. NeuN and neurofilament H (NF-H) staining were performed, and additionally a pS6 antibody was used to demonstrate mTOR pathway activation.

RESULTS
In 32 cases diagnosed with FCD, or 17.5% of 183 surgical epilepsy materials, there were no significant differences in the statistical analysis of clinical variables between the ILAE FCD subtypes. Recommended antibody NeuN revealed microcolumnar alignment in the FCD type Ia and IIIa groups and the loss of lamination in the type Ib group. Another recommended antibody, NF-H, was not found to be useful in discriminating between normal and dysmorphic neurons. pS6 expression, showing mTOR pathway activation, was observed in dysmorphic neurons and balloon cells in all FCD type II cases.

CONCLUSIONS
Significant pS6 expression in FCD type II represents the genomic nature of the disease noted in the literature. Nevertheless, the known MTOR gene and mTOR pathway–related mutations remain behind proportionally to explain the mTOR pathway activation in all FCD type II cases. Clinicopathologically and genetically integrated classification and usage of mTOR pathway inhibitors in treatment are expected as a recent evolution.
Deep brain stimulation in children and youth: perspectives of patients and caregivers gleaned through Twitter
Authors: Elkaim Lior M. , Niazi Farbod , Levett Jordan J. , Bokhari Rakan , Gorodetsky Carolina , Breitbart Sara , Alotaibi Fahad , Alluhaybi Abdulelah A. , Weil Alexander G. , Fallah Aria , Alotaibi Naif M. , Ibrahim George M. 
Published: October 2022

OBJECTIVE
This study aims to glean patient and caregiver perspectives surrounding deep brain stimulation (DBS) in children and youth through an analysis of patterns of social media usage.

METHODS
The authors performed a comprehensive search of the Twitter Application Programming Interface (API) database for all tweets about DBS use in children and youth, with no date restriction. Data pertaining to each tweet were extracted for analysis. Results were analyzed using qualitative and quantitative methodologies. These included thematic analysis of tweets, accounts, and descriptive statistics. Sentiment analysis of extracted tweets was also performed. A multivariable regression model was used to identify predictors of higher engagement metrics (likes, retweets, and quotes).

RESULTS
A comprehensive search of the Twitter database yielded 877 tweets from 816 unique accounts meeting study inclusion criteria. Most tweets were from patients or caregivers, researchers, or news media outlets. The most common themes among analyzed tweets were research discussing novel findings (45.2%) or personal experiences of patients or caregivers (27.4%). Sentiment analysis showed that 54.5% of tweets were positive, 35.1% were neutral, and 10.4% were negative. The presence of pictures or videos increased the tweet engagement count by an average of 10.5 (95% CI 7.3–13.6). Tweets about personal patient experiences (β = 6, 95% CI 0.95–12) and tweets tagging other accounts (β = 3.2, 95% CI 0.63–5.8) were also significantly associated with higher engagement metrics.

CONCLUSIONS
The current study is the first to assess patient and caregiver perspectives surrounding pediatric DBS through a comprehensive analysis of social media usage. Given the nascent field, social media presents an opportunity to share experiences and promote patient and healthcare professional education surrounding pediatric DBS.
Spinal cord stimulation for treatment of chronic neuropathic pain in adolescent patients: a single-institution series, systematic review, and individual participant data meta-analysis
Authors: Bakr Salma M. , Knight James A. , Shlobin Nathan A. , Budnick Hailey , Desai Virendra , Hill Haley , Johnson Sarah K. , Williams Amy E. , Tolley James A. , Raskin Jeffrey S. 
Published: October 2022

OBJECTIVE
Neuropathic pain is undertreated in children. Neurosurgical treatments of pediatric chronic pain are limited by the absence of both US Food and Drug Administration approval and pediatric-specific hardware, as well as weak referral patterns due to a lack of physician education. This study presents a single-institution retrospective case series of spinal cord stimulation (SCS) in children ≤ 19 years of age and a systematic review of SCS in children. The authors’ findings may further validate the role of SCS as an effective treatment modality for varied neuropathic pain syndromes found in pediatric patients.

METHODS
The study was a single-center, single-surgeon, retrospective case series of individuals treated between July 2017 and May 2022. The outcomes for pediatric patients with chronic neuropathic pain syndromes indicated by the multidisciplinary pain clinic for evaluation for SCS were cataloged. A systematic review and individual participant data (IPD) meta-analysis was performed for cases treated until May 2022, using PubMed, EMBASE, and Scopus to characterize outcomes of children with neuropathic pain treated with SCS.

RESULTS
Twelve patients were evaluated and 9 were indicated for percutaneous or buried lead trials. Seven female and 2 male patients between the ages of 13 and 19 years were implanted with trial leads. Eight of 9 (89%) patients went on to receive permanent systems. The average trial length was 6 days, and the length of stay for both trial and implant was less than 1 day. Complication rates due to CSF leaks were 22% and 0% for trial and implant, respectively. Visual analog scale pain scores decreased from 9.2 to 2.9 (p = 0.0002) and the number of medications decreased from 4.9 to 2.1 (p = 0.0005). Functional status also improved for each patient. A systematic review identified 13 studies describing pediatric patients with SCS, including 12 providing IPD on 30 patients. In the IPD meta-analysis, pain was reduced in 16/16 (100%) of patients following surgery and in 25/26 (96.2%) at last follow-up. Medication use was decreased in 16/21 (76.2%), and functional outcomes were improved in 29/29 (100%). The complication rate was 5/30 (16.7%).

CONCLUSIONS
SCS effectively decreases pain and medication use for pediatric neuropathic pain syndromes. Patients also report improved functional status, including improved matriculation, gainful employment, and physical activity. There is minimal high-quality literature describing neuromodulation for pain in children. Neuromodulation should be considered earlier as a viable alternative to escalating use of multiple drugs and as a potential mechanism to address tolerance, dependence, and addiction in pediatric patients.
Responsive neurostimulation for pediatric patients with drug-resistant epilepsy: a case series and review of the literature
Authors: Curtis Kendall , Hect Jasmine L. , Harford Emily , Welch William P. , Abel Taylor J. 
Published: October 2022

OBJECTIVE
Responsive neurostimulation (RNS) is a promising treatment for pediatric patients with drug-resistant epilepsy for whom resective surgery is not an option. The relative indications and risk for pediatric patients undergoing RNS therapy require further investigation. Here, the authors report their experience with RNS implantation and therapy in pediatric patients.

METHODS
The authors performed a retrospective chart review to identify patients implanted with RNS depth or strip electrodes for the treatment of drug-resistant epilepsy at their institution between 2020 and 2022. Patient demographics, surgical variables, and patient seizure outcomes (Engel class and International League Against Epilepsy [ILAE] reporting) were evaluated.

RESULTS
The authors identified 20 pediatric patients ranging in age from 8 to 21 years (mean 15 [SD 4] years), who underwent RNS implantation, including depth electrodes (n = 15), strip electrodes (n = 2), or both (n = 3). Patient seizure semiology, onset, and implantation strategy were heterogeneous, including bilateral centromedian nucleus (n = 5), mesial temporal lobe (n = 4), motor cortex or supplementary motor area (n = 7), or within an extratemporal epileptogenic zone (n = 4). There were no acute complications of RNS implantation (hemorrhage or stroke) or device malfunctions. One patient required rehospitalization for postoperative infection. At the longest follow-up (mean 10 [SD 7] months), 13% patients had Engel class IIB, 38% had Engel class IIIA, 6% had Engel class IIIB, 19% had Engel class IVA, 19% had Engel class IVB, and 6% had Engel class IVC outcomes. Using ILAE metrics, 6% were ILAE class 3, 25% were ILAE class 4, and 69% were ILAE class 5.

CONCLUSIONS
This case series supports current literature suggesting that RNS is a safe and potentially effective surgical intervention for pediatric patients with drug-resistant epilepsy. The authors report comparable rates of serious adverse events to current RNS literature in pediatric and adult populations. Seizure outcomes may continue to improve with follow-up as stimulation strategy is refined and the chronic neuromodulatory effect evolves, as previously described in patients with RNS. Further large-scale, multicenter case series of RNS in pediatric patients with drug-resistant epilepsy are required to determine long-term pediatric safety and effectiveness.