bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differentiation of Parkinson’s disease and Parkinsonism predominant multiple system atrophy in early stage by morphometrics in susceptibility weighted imaging
Authors: Ren Qingguo , Wang Yihua , Xia Xiaona , Zhang Jianyuan , Zhao Cuiping , Meng Xiangshui 
Published: August 2022

Background and purposeWe previously established a radiological protocol to discriminate multiple system atrophy-parkinsonian subtype (MSA-P) from Parkinson’s disease (PD). However, we do not know if it can differentiate early stage disease. This study aimed to investigate whether the morphological and intensity changes in susceptibility weighted imaging (SWI) of the lentiform nucleus (LN) could discriminate MSA-P from PD at early stages.MethodsWe retrospectively enrolled patients with MSA-P, PD and sex- and age-matched controls whose brain MRI included SWI, between January 2015 and July 2020 at the Movement Disorder Center. Two specialists at the center reviewed the medical records and made the final diagnosis, and two experienced neuroradiologists performed MRI analysis, based on a defined and revised protocol for conducting morphological measurements of the LN and signal intensity.ResultsNineteen patients with MSA-P and 19 patients with PD, with less than 2 years of disease duration, and 19 control individuals were enrolled in this study. We found that patients with MSA- P presented significantly decreased size in the short line (SL) and corrected short line (cSL), ratio of the SL to the long line (SLLr) and corrected SLLr (cSLLr) of the LN, increased standard deviation of signal intensity (SIsd_LN, cSIsd_LN) compared to patients with PD and controls (P &lt; 0.05). With receiver operating characteristic (ROC) analysis, this finding had a sensitivity of 89.5% and a specificity of 73.7% to distinguish MSA- P from PD.ConclusionCompared to PD and controls, patients with MSA-P are characterized by a narrowing morphology of the posterior region of the LN. Quantitative morphological changes provide a reference for clinical auxiliary diagnosis.
Therapeutic Uses and Pharmacological Properties of Shallot (Allium ascalonicum): A Systematic Review
Authors: Moldovan Cadmiel , Frumuzachi Oleg , Babotă Mihai , Barros Lillian , Mocan Andrei , Carradori Simone , Crişan Gianina 
Published: August 2022

BackgroundShallot (Allium ascalonicumL.) is a traditional plant species used throughout the world both for culinary purposes and as a folk remedy. To date (i.e., April 2022), there is no report on the main pharmacological activities exerted by shallot preparations and/or extracts.Scope and ApproachThe aim of this study was to comprehensively review the pharmacological activities exerted by shallot, with rigorous inclusion and exclusion criteria based on the scientific rigor of studies. Prisma guidelines were followed to perform the literature search.Key Findings and ConclusionsThe literature search yielded 2,410 articles of which 116 passed the required rigorous criteria for inclusion in this review. The extracts exert a potent antioxidant activity bothin vitroandin vivo, as well as a strong inhibitory capacity on various pathogens with relevant implications for public health. Moreover, shallot can be used as adjuvant therapy in cardiovascular diseases, diabetes, cancer prevention, and other non-communicable diseases associated with inflammatory and oxidative pathways. Future studies investigating the chemical composition of this species, as well as the molecular mechanisms involved in the empirically observed pharmacological actions are required.
Research trends of artificial intelligence in pancreatic cancer: a bibliometric analysis
Authors: Yin Hua , Zhang Feixiong , Yang Xiaoli , Meng Xiangkun , Miao Yu , Noor Hussain Muhammad Saad , Yang Li , Li Zhaoshen 
Published: August 2022

PurposeWe evaluated the related research on artificial intelligence (AI) in pancreatic cancer (PC) through bibliometrics analysis and explored the research hotspots and current status from 1997 to 2021.MethodsPublications related to AI in PC were retrieved from the Web of Science Core Collection (WoSCC) during 1997-2021. Bibliometrix package of R software 4.0.3 and VOSviewer were used to bibliometrics analysis.ResultsA total of 587 publications in this field were retrieved from WoSCC database. After 2018, the number of publications grew rapidly. The United States and Johns Hopkins University were the most influential country and institution, respectively. A total of 2805 keywords were investigated, 81 of which appeared more than 10 times. Co-occurrence analysis categorized these keywords into five types of clusters: (1) AI in biology of PC, (2) AI in pathology and radiology of PC, (3) AI in the therapy of PC, (4) AI in risk assessment of PC and (5) AI in endoscopic ultrasonography (EUS) of PC. Trend topics and thematic maps show that keywords " diagnosis ", “survival”, “classification”, and “management” are the research hotspots in this field.ConclusionThe research related to AI in pancreatic cancer is still in the initial stage. Currently, AI is widely studied in biology, diagnosis, treatment, risk assessment, and EUS of pancreatic cancer. This bibliometrics study provided an insight into AI in PC research and helped researchers identify new research orientations.
Family influences on older adults' problem drinking: A representative nationwide study of China
Authors: Ye Yaping , Feng Jian , Zhang Yeyuan , Wang Manli , Chen Jinsong , Wu Dan , Kathleen Young , Jiang Shuhan 
Published: August 2022

AimIt is reported that problem drinking is severe among the elderly. The family environment has been regarded as a significant effecting factor in alcohol consumption of the drinker. With the increasing number of older people, paying more attention to this vulnerable group's drinking status and its' influencing factors is substantial for improving older adults' health and the quality of health services.MethodsThis study used data from the Chinese Longitudinal Healthy and Longevity Study (CLHLS), which was a representative survey covering 23 provinces in mainland China. Cross-sectional analyses were conducted with 15,142 older individuals (aged ≥65 years). Three self-reported questions about drinking behavior were examined to calculate alcohol consumption and categorize problem drinkers. Three multi-level models were utilized while adjusting for numerous socio-demographic and self-reported health factors to analyze the effect of family factors associated with problem drinking among the elderly.ResultsA total of 1,800 problem drinkers (12%) were identified in the sample. Key factors for the problem drinker were assessed such as Hukou (governmental household registration system), current marital status, years of schooling, primary caregivers, and financial sources of living were associated with problem drinking. The older population who live in rural areas (OR = 1.702, CI = 1.453, 1.994), with advanced years of education (OR = 1.496, CI = 1.284, 1.744), and making life by themselves (OR = 1.330, CI = 1.139, 1.552) were more likely to engage in problem drinking while those participants who are widowed (OR = 0.678, CI = 0.574, 0.801), cared for by children or other relatives (OR = 0.748, CI = 0.642, 0.871), adult care giver (OR = 0.348, CI = 0.209, 0.578) or by no one (OR = 0.539, CI = 0.348, 0.835), provided with financial support from their children (OR = 0.698, CI = 0.605, 0.806), other relatives (OR = 0.442, CI = 0.332, 0.587), or the government/community (OR = 0.771, CI = 0.650, 0.915), with insufficient financial support (OR = 0.728, CI = 0.608, 0.872) were at lower risk of problem drinking.ConclusionsThis study provides a strong correlation of various family factors that were associated with problem drinking among the elderly. The findings underscore the effort to promote healthy behaviors, including the importance of positive family factors and appropriate levels of alcohol consumption.
Evaluation of stroke health education for primary school students in Dali, China
Authors: Yang Yunjuan , Dai Jing , Min Jieqing , Song Zhizhong , Zha Shun , Chang Litao , Chai Jiajia , Yang Youpei , Liu Yang , Zhang Xin , Wu Xiyun , Gong Yuwen , Wang Xin , Li Fang , Qin Haiyan 
Published: August 2022

ObjectivesTo provide us with some evidence to develop more targeted stroke intervention strategies, improve the health awareness of stroke among children, and advocate the health promotion campaign of “small hands holding big hands” among parents and children, we have conducted a health education program on stroke among primary school students in Dali.MethodsThis study has applied stratified random cluster sampling in Dali of Yunnan, China. We compared the improvement of students' knowledge of stroke before and after our health education program in primary school students of Dali in October 2020. Data were collected through 3 rounds of survey by using the same questionnaire.ResultsThere were 215 participants aged 7–8 years old sampled in the first phase of the study and 145 participants in the follow-up study. The knowledge of stroke among the participants was relatively low in the pre-intervention survey. After the health education, all the indicators on stroke knowledge were improved. The correct rates in stroke definition, sequelae, and “1-2-0” identification were increased from 0 to 66.05%, to 53.95% and 64.19%, respectively, in both pre-intervention and post-intervention surveys. The correct rate of stroke knowledge was about 4.83–92.41% 3 months after the intervention. The mean score of the questionnaire was 4.25 ± 0.19 in the pre-intervention survey, and that was 15.85 ±0.27 in the post-intervention one. The mean score was 14.02 ± 0.28 post-3-month test. The score in the 3-month survey after the intervention was 11.55% lower than that in the post-intervention score.ConclusionsThe effect of stroke-related knowledge in the health education program for children is improved significantly and this can last for 3 months but it also had attenuation. We should repeat pertinent health education among students.
Socioeconomic inequality in health care use among cancer patients in China: Evidence from the China health and retirement longitudinal study
Authors: Zhang Huiru , Fu Yu , Chen Mingsheng , Si Lei 
Published: August 2022

BackgroundCancer is a major public health problem worldwide and the leading cause of death in China, with increasing incidence and mortality rates. This study sought to assess socioeconomic-related inequalities in health care use among cancer patients in China and to analyze factors associated with this disparity.MethodsThis study used data collected for the China Health and Retirement Longitudinal Study in 2018. Patients who reported having cancer were included. The annual per capita household expenditure was classified into five groups by the quintile method. We calculated the distribution of actual, need-predicted, and need-standardized health care use across different socioeconomic groups among patients with cancer. The concentration index (CI) was used to evaluate inequalities in health care use. Influencing factors of inequalities were measured with the decomposition method.ResultsA total of 392 people diagnosed with cancer were included in this study. The proportion of cancer patients who utilized outpatient and inpatient services was 23.47% and 40.82%, respectively, and the CIs for actual outpatient and inpatient service use were 0.1419 and 0.1960. The standardized CIs (CI for outpatient visits = 0.1549; CI for inpatient services = 0.1802) were also both positive, indicating that affluent cancer patients used more health services. The annual per capita household expenditure was the greatest factor favoring the better-off, which contributed as much as 78.99% and 83.92% to the inequality in outpatient and inpatient services use, followed by high school education (26.49% for outpatient services) and living in a rural village (34.53% for inpatient services). Urban Employee Basic Medical Insurance exacerbated the inequality in inpatient services (21.97%) while having a negative impact on outpatient visits (−22.19%).ConclusionsThere is a pro-rich inequality in outpatient and inpatient services use among cancer patients in China. A lower socioeconomic status is negatively associated with cancer care use. Hence, more targeted financial protection for poor people would relieve cancer patients of the burden caused by the high cost of cancer care.
Reseña de: El país indiviso, de Roxana Boixadós y Judith Farberman (2021). Ciudad Autónoma de Buenos Aires, Prometeo Libros
Authors: Larreburo Mario Emanuel 
Published: August 2022

El libro tiene como objetivo estudiar la configuración de la región de Los Llanos -actual Argentina- durante el largo siglo XVIII, analizando sus dinámicas geográficas y sociales y los conflictos en torno a las tierras; es un importante aporte para el campo de los estudios histórico antropológicos de de dicha región pues da cuenta de las condiciones de formación y las transformaciones de los campos comunes o estancias indivisas durante el siglo XVIII. El análisis de los pleitos por tierras permitió a las autoras dar cuenta de la propiedad indivisa, funcional a la actividad ganadera ya que evitaba la fragmentación de las estancias.
THE ANALYSIS OF THE MECHANISMS OF FAMILY BEHAVIOR UNDER FAMILY STRESS CONNECTED WITH A CANCER IN A CHILD
Authors: Гусева М.А. , Цейтлин Г.Я. , Коптева Е.С. , Антонов А.И. , Румянцев А.Г. 
Published: August 2022

По данным отечественных и зарубежных исследований, члены семьи в период противоопухолевого лечения ребенка переживают хронический эмоциональный стресс, последствиями которого могут быть существенные трансформации семейного поведения. Цель исследования изучение специфики семейного поведения родителей в стрессогенной ситуации лечения онкологического заболевания у ребенка и анализ факторов, изменяющих структуру диспозиционной регуляции жизнедеятельности семьи. Методом анкетного опроса обследованы 1298 родителей с ребенком, страдающим онкологическим заболеванием в состоянии ремиссии, из 78 регионов РФ. Группа сравнения из исследования Росстата Семья и рождаемость 2009 г. В исследуемой генеральной совокупности отмечены существенные отличия: повышение доли неработающих матерей и доли семей с низким доходом, снижение доли семей, состоящих в незарегистрированном браке. Выявлены особенности репродуктивного поведения: повышенные репродуктивные установки, более высокая детность, трансформация системы ценностей с доминированием ценностей семьи и брака. В статье представлено социологодемографическое объяснение полученным данным, раскрыт поведенческий механизм, повышающий репродуктивные установки, и, тем самым, увеличивающий число рождений в семье
According to domestic and foreign studies, family members during the period of antitumor treatment of a child experience chronic emotional stress, the consequences of which can be significant transformations of family behavior. The purpose of the study is to study the specifics of the family behavior of parents in a stressful situation of cancer treatment in a child and to analyze factors that change the structure of dispositional regulation of family activity. The method of the questionnaire survey examined 1298 parents with a child suffering from an oncological disease in remission from 78 regions of the Russian Federation. The comparison group is from the Rosstat Family and Fertility study in 2009. In the studied population, there were significant differences: an increase in the proportion of nonworking mothers and the proportion of lowincome families, a decrease in the proportion of families in an unregistered marriage. The features of reproductive behavior are revealed: increased reproductive attitudes, higher level of detail, transformation of the value system with the dominance of family and marriage values. The article presents a sociological and demographic explanation of the data obtained, discloses a behavioral mechanism that enhances reproductive attitudes, and thus increases the number of births in a family
EXPERIENCE OF USING AQUALOR PROTECT® SALT SOLUTION FOR THE TREATMENT OF RECURRENT ACUTE RINOSINUSITIS IN CHILDREN
Authors: Гизингер О.А. , Щетинин С.А. , Корнова Н.В. 
Published: August 2022

В исследовании приняли участие 62 ребенка в возрасте от 5 до 8 лет, в анамнезе у которых наблюдалось более 5 эпизодов острого риносинусита в год. Целью исследования стало изучение клиникоиммунологической эффективности и безопасности топического применения гипертонического солевого раствора Аквалор Протект в комплексной терапии у детей с рецидивирующим острым риносинуситом. Для достижения цели исследования были сформированы 2 группы: 1 группа состояла из 33 детей, в комплексное лечение которых входил препарат Аквалор Протект, группа 2 (сравнения) состояла из 29 детей. Результаты исследования: комплексная терапия с применением назального спрея Аквалор Протект позволяет сократить сроки лечения, уменьшить количество рецидивов острого риносинусита, функционально восстановить метаболический статус фагоцитов поверхности слизистой оболочки полости носа. Анализ полученных результатов позволяет рекомендовать Аквалор Протект для включения в комплекс лечебнопрофилактических мероприятий у детей с рецитдивирующим острым риносинуситом.
The study involved 62 children aged 5 to 8 years in the history of which more than 5 episodes per year of acute rhinosinusitis. Objective: to study the clinical and immunological efficacy and safety of the topical application of the Aqualor Protect hypertonic saline solution in the treatment of children with recurrent acute rhinosinusitis. To achieve the goal of the study, 2 groups were formed: 1 group consisted of 33 children, the complex treatment of which included the drug Aqualore Protect, group 2 (comparison) consisted of 29 children. Results of the study: complex therapy with the use of Aqualor Protect nasal spray can reduce the time of treatment, reduce the number of relapses of acute rhinosinusitis, and restore the functional metabolic status of phagocytes on the surface of the nasal mucosa. The analysis of the obtained results allows recommending Aqualor Protect to be included in the complex of therapeutic and preventive measures in children with relapsing acute rhinosinusitis
ELABORATION AND IMPLEMENTATION OF INTERNAL APPRAISAL OF EMPLOYEE PERFORMANCE IN HEALTHCARE
Authors: Комиссаров Е.Е. 
Published: August 2022

В работе руководителя важно проводить объективную оценку результатов деятельности подчиненных, оценивать уровень их профессиональных знаний и навыков, понимать соответствие работников ожиданиям руководителя и вектору развития организации. В статье рассмотрены преимущества использования внутренней оценки персонала на основе компетенций, описано поэтапное формирование и внедрение этой системы в ГБУЗ Челябинская областная детская клиническая больница.
An important managers task in working with subordinates is an objective assessment of their productivity, level of professional knowledge and skills, as well as compliance of employees with managers expectations and development vector of the organization. The article discusses the advantages of using of the internal appraisal of employee performance, describes the phased establishment and implementation of this system in Chelyabinsk Regional Childrens Clinical Hospital.
CURRENT ISSUES OF DETERMINING MICROELEMENTS: OPPORTUNITIES OF MODERN LABORATORY
Authors: Гизингер О.А. , Силкина Т.А. , Пешикова М.В. 
Published: August 2022

Дефицит микроэлементов, повсеместно регистрируемый среди детей, приводит к задержке физического и нервнопсихического развития, повышает риск возникновения и хронизации различных заболеваний. Длительное отсутствие в рационе некоторых нутриентов или наоборот присутствие их в почве и воде в превышающих нормы количествах может вызывать необратимые изменения в организме. В статье рассматривается физиологическая роль минеральных веществ, макро и микроэлементов, особенности их метаболизма, нормы содержания у детей, основные причины их дефицита в рационе, приводятся рекомендации по выбору материала для исследования микроэлементного состава и возможностях лабораторной диагностики микроэлементозов
Micronutrient deficiency, соmmоnly reсоrded among children leads to stunted physical and mental development, increases the risk of оссurrenсe and сhrоniсity of various diseases. Prolonged absence of some nutrients in the diet оr Viсe versa, the presence of excess amounts in the soil and water can cause irreversible changes in the body. The article deals with the physiоlоgiсal role of minerals, maсrо and microelements, their metabolism, the соntent of children, the main causes of their deficiency in the diet. Recommendations on the choice of material for the study of the microelement composition and the possibilities of laboratory diagnosis of microelementoses are given
GEOGRAPHIC DISTRIBUTION OF PATIENTS WITH ONCOLOGICAL, HEMATOLOGICAL, IMMUNOLOGICAL DISEASES, HOSPITALIZED IN THE NATIONAL SCIENTIFIC MEDICAL CENTER
Authors: Скрипкин А.В. , Ставчанский Р.Ю. , Ишкова Т.А. 
Published: August 2022

В статье обсуждается актуальность изучения географического варьирования обращений пациентов за специализированной, высокотехнологичной медицинской помощью в НМИЦ ДГОИ им. Дмитрия Рогачева. Для проведения анализа авторы используют метод графического картирования. Источником данных о случаях обращений пациентов является электронная медицинская база. Полученные данные, позволили выявить наиболее значимые тенденции медикосоциального характера, влияющие на направление детей в ЛРНЦ Русское поле для получения высококвалифицированной реабилитационной помощи. Авторы полагают, что важно повысить информированность врачей и родителей по вопросам реабилитации. Изучение географического распределения, как частотных параметров эпидемиологического процесса, так и реабилитационных программ призвано повысить эффективность оказания медицинской помощи пациентам с онкологическими, гематологическими и иммунологическими заболеваниями
The authors discuss in the article the relevance of studying the geographical variation of patients requests for specialized, hightech medical care at the Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology. For the analysis, the authors use the method of graphical mapping. The source of data on cases of patient visits is the electronic medical database. The obtained data allowed identifying the most significant medical and social trends affecting the referral of children to the Medical and Rehabilitation Scientific Center Russian Field for obtaining highly qualified rehabilitation assistance. The authors believe that it is important to increase the awareness of doctors and parents on rehabilitation issues. The study of the geographical distribution of both the frequency parameters of the epidemiological process and rehabilitation programs is intended to increase the efficiency of medical care for patients with cancer, hematological and immunological diseases
IN HELP TO THE DOCTOR-PEDIATRIC: LABORATORY RESEARCH IN DIAGNOSTICS OF FREQUENTLY MEETED DISEASES (RECOMMENDATIONS OF THE FEDERAL MEDICAL COMPANY "HEMOTEST")
Authors: Силкина Т.А. , Петрова О.Г. , Морозова В.С. , Иванова Т.В. , Бойко Р.З. , Бурова Д.А. , Гизингер О.А. 
Published: August 2022

Возможности лабораторной диагностики в педиатрической практике все больше расширяются: внедрение инновационных технологий способствует появлению новых, более качественных методов исследований. В статье рассмотрены наиболее актуальные диагностические направления, для которых предлагаются высокотехнологичные, точные и быстрые в выполнении медицинские тесты
The possibilities of laboratory diagnostics in pediatric practice are expanding more and more: the introduction of innovative technologies contributes to the emergence of new, higherquality research methods. Consider the most current diagnostic areas for which we offer hightech, accurate and fast to perform medical tests