bluuebunny/crossref_metadata_2025_split huggingface dataset:
$W_w (IR)$ uzayının bazı özellikleri
Authors: DOĞAN Mevlüde , GÜRKANLI A. Turan 
Published: February 2022

Wp(IRn)Wp(IRn) uzayı ve bu uzaya ait bazı özellikler Krogstad [1] tarafından ispat edilmiştir. Bu çalışmada, Krogstad tarafından tanımlanan bu uzayın p=1p=1 için özel durumu olan W(IRn)W(IRn) uzayı ele alındı. ww, IRIR reel sayılar kümesinde Beurling-Domar koşullarını sağlayan ağırlık fonksiyonu olmak üzere bir Ww(IR)Ww(IR) uzayı ve bu uzay üzerinde ∥.∥w‖.‖w normu tanımlandı. Ww(IR)Ww(IR) uzayının, ∥.∥w‖.‖w normuna göre bir Banach uzayı olduğu ispatlandı. (Ww(IR),∥.∥w)(Ww(IR),‖.‖w) uzayının bir Banach cebiri, ötelemeler altında invaryant ve kuvvetli invaryant olduğu gösterildi. Ayrıca, (Ww(IR),∥.∥w)(Ww(IR),‖.‖w) uzayının Soyut Segal cebiri ve Banach fonksiyon uzayı olduğu ispatlandı. w1w1, w2w2, IRIR üzerinde ağırlık fonksiyonları olmak üzere Ww1(IR)Ww1(IR)W(w1)(IR) ve $W_{w_2}(IR)$W(w2)(IR) uzayları arasındaki kapsama özellikleri araştırıldı.
THE EFFECT OF DISCLOSURE OF SUSTAINABILITY REPORTING BASED ON GRI STANDARDS ON COMPANY PERFORMANCE (Study on Non-Financial Companies Listed on the SRI-KEHATI Index 2017-2019)
Authors: Eriyanti Yuyun 
Published: February 2022

This research was conducted to test: (1) The effect of the economic dimension sustainability report disclosure on company performance; (2) The effect of the environmental dimension sustainability report disclosure on company performance; (3) The effect of disclosure of the social dimension sustainability report on company performance. The population of this study was 30 companies listed on the SRI-KEHATI index 2017-2019. Based on the purposive sampling method, the total sample of the study was 14 companies. Hypothesis testing is carried out in this study using multiple linear regression analysis with the help of SPSS version 26 software. The results showed that (1) the economic dimension has no effect on company performance (Tobin's Q) with a significance level of the economic dimension of 0.450. (2) The environmental dimension has an effect on company performance (Tobin's Q) with a significant level of the environmental dimension of 0.002. (3) The social dimension affects Company Performance (Tobin's Q) with a social dimension significance level of 0.000.
Analisis Gerakan Tanah Longsor Di Wilayah Cekungan Bandung dan Sekitarnya
Authors: Yuda Himmes Fitra , Amri M Adimas , Asseggaf Abdurrachman 
Published: February 2022

Gerakan massa tanah/batuan atau longsor juga dapat diartikan sebagai gerakan menurunin lereng oleh massa tanah atau batuan penyusun lereng. Lereng yang hambat geser tanah/batuannya lebih kecil dari berat massa tanah itu sendiri akan membuat pergerakan massa tanah. Diperlukan upaya untuk mengurangi resiko potensi gerakan tanah, antara lain dengan melakukan analisis sistem informasi geografis (SIG) menggunakan tiga parameter terdiri dari; parameter geologi, curah hujan, dan bentang alam. Daerah cekungan bandung dan sekitarnya rentan terhadap gerakan tanah. Hal ini yang mendorong dibutuhkannya penelitian untuk menentukan zonasi kerentanan dalam upaya meminimalisir tingkat kerugian akibat terjadinya bencana. Selain itu upaya tersebut sangat dibutuhkan dalam rekomendasi atau menentukan arah pembangunan strategis dalam perencanaan tata ruang wilayah. Tujuan dari penelitian ini untuk melakukan analisis kajian kebencanaan gerakan tanah dilihat dari kondisi geologi, bentang alam dan intensitas curah hujan. Penelitian ini dilakukan dengan melakukan pengumpulan data secara primer yaitu dengan melakukan pengamatan langsung ke lapangan maupun secara sekunder berupa peta tematik dari pemerintah daerah setempat. Berdasarkan Bentang Alam (% lereng), jenis litologi dan Curah Hujan yang berkisar 1500 - 3500 mm/tahun, gerakan tanah di daerah penelitian dapat dikelompokan menjadi 4 (empat) yaitu, Erosi Tebing, Longsoran, Gelinciran, dan Kompleks.
Fatores associados em gestantes com Lúpus Eritematoso Sistêmico
Authors: Oliveira Rege Farias , Vale Eise Souza do , Brito Ana Luiza Neves , Bonfim Gabriella Mesquita , Pereira Danilo Anderson , Trindade Emmanuel Santos , Cabral Fernando de Almeida , Fernandes Lidia Jacinta Nunes , Rocha Andreza Carcará , Amaral Juliana Oliveira Leal 
Published: February 2022

Objetivo: Compreender as repercussões da Lúpus Eritematoso Sistêmico (LES) em gestantes. Revisão bibliográfica: O LES é mais acometido no sexo feminino ocorrendo em fase reprodutiva na faixa etária de 20 a 45 anos. As pacientes portadoras de LES durante período gestacional, são consideradas de alto risco pelo fato de haver um quadro com uma maior incidência de complicações tanto para a gestante e também para o feto como: parto prematuro, exacerbação da atividade da doença, retardo do crescimento intrauterino, pré-eclâmpsia e perda fetal. Com relação à gravidez, em torno de 50% das gestações em mulheres com lúpus não apresentam alteração ou comprometimento na gravidez sendo normais, e 25% geram bebês que nascem com complicações por ser prematuros e o restante, correspondem, ao aborto espontâneo ou morte do bebê. Considerações finais: A LES apresenta uma gama de sinais e sintomas nas gestantes alterando as atividades fisiológicas da mulher. Assim, trata-se de uma doença que não tem cura, mas apenas controle e prevenção durante o período da gestação, no início da gestação e pós gestação. Para reduzir tal morbimortalidade materna-fetal recomenda-se um acompanhamento de uma equipe multidisciplinar preconcepção.
REFLECTION OF AESTHETIC IDEAS OF MUSLIM CULTURE IN THE WORK OF THINKERS OF THE EAST
Authors: Исаков К.А. , Азизова Д.Ш. , Матаев М.А. 
Published: February 2022

В статье проанализированы эстетические идеи мусульманской культуры и рассмотрены разноречивые стороны прогрессивных мыслителей Востока относительно норм Ислама, проблемы сущности ве ликолепия Аллаха и красоты потустороннего мира, проблемы влияния сверхъестественных сил на красоту материального мира, материальная действительность и духовные деяния. Анализ дается на примере героического эпоса Фирдоуси, включаю щего драматические и лирические элементы, и замечательных философских рубаи Ибн Сины и Омара Хайяма, Мутаннаби, Рудаки.
The article analyzes the aesthetic ideas of Muslim culture and examines the controversial aspects of progressive thinkers of the East regarding Islamic norms, the problems of the essence of the greatness of Allah and the beauty of the other world, the problems of the infl uence of supernatural forces on the beauty of the material world, material reality and spiritual deeds. The analysis is given on the example of the heroic epic of Firdousi, including dramatic and lyrical elements, and the wonderful philosophical rubyes of Ibn Sina and Omar Khayyam, Mutannaby, Rudaki.
Broken Heart Syndrome: Berawal dari Stres Menuju Gagal Jantung
Authors: Sukma Alshafiera Azayyana Mawadhani , Balatif Ridwan 
Published: February 2022

Background: When stress conditions can be the root of various diseases, one of which is Broken Heart Syndrome (BHS). It is estimated that 90% of cases of BHS occur in women who have entered postmenopause. The mortality from BHS cases is quite high, reaching 2-5% with the main cause of death due to cardiogenic shock and ventricular fibrillation.
Objective: To provide the latest information about BHS from various literatures.
Methods: Writing this article using a literature searching method. Search for articles using the help of search engines in the form of Google Scholar, Pubmed and Clinicalkey with articles that have been published in the last 10 years and in English.
Discussion: Prolonged physical stress conditions can trigger BHS. Risk factors associated with BHS conditions include age over 55 years, smoking, excessive alcohol consumption, a history of anxiety and hyperlipidemia. Complications can occur in 52% of cases of BHS. Mortality in BHS cases tended to be higher in BHS cases that was triggered by physical factors than that triggered by emotional factors.
Conclusion: BHS is a condition that occurs after emotional stress or physical stress, so controlling the stress triggers is expected to prevent the occurrence of BHS.
Keywords: broken heart syndrome, stress, heart failure

Latar belakang: Kondisi stres saat dapat menjadi akar dari berbagai macam penyakit salah satunya Broken Heart Syndrome (BHS). Diperkirakan 90% kasus BHS terjadi pada perempuan yang sudah memasuki postmenopause. Mortalitas dari kasus BHS cukup tinggi yakni mencapai 2-5% dengan penyebab kematian utama dikarenakan shok kardiogenik dan ventrikular fibrilasi.
Tujuan: Memberikan informasi terkini seputar BHS dari berbagai literatur.
Metode: Penulisan artikel ini menggunakan metode literature searching. Pencarian artikel menggunakan bantuan mesin pencari berupa Google Scholar, Pubmed, dan Clinicalkey dengan artikel yang telah dipublikasikan dalam 10 tahun terakhir dan berbahasa Inggris.
Pembahasan: Kondisi stres fisik yang berkepanjangan dapat mencetuskan BHS. Faktor risiko yang berkaitan dengan kondisi BHS berupa usia diatas 55 tahun, merokok, konsumsi alkohol berlebih, riwayat ansietas dan hiperlipidemia. Komplikasi dapat terjadi pada 52% kasus BHS. Mortalitas pada kasus BHS cenderung lebih tinggi pada kasus BHS yang dipicu oleh faktor fisik dibandingkan yang dipicu oleh faktor emosi.
Kesimpulan: BHS ini adalah kondisi yang timbul pasca stres emosional atau fisik sehingga dengan mengendalikan faktor pencetus stres ini diharapkan dapat mencegah terjadinya BHS.
Kata Kunci: broken heart syndrome, stres, gagal jantung
Experiencia pedagógica en la formación del programa Contaduría Pública, asignatura: “Tributaria II”
Authors: González Carreño Liz Farith 
Published: February 2022

El presente texto tiene como finalidad, exponer la experiencia pedagógica lograda a partir de la enseñanza en el programa de contaduría Pública en la Fundación Universitaria del Área Andina; para efecto tal, se propone un objetivo final que busca mejorar el desempeño académico de los estudiantes de dicho programa, en el área de tributaria II; para lograrlo, se tuvo en cuenta los principales elementos considerados como base fundamental de la propuesta pedagógica, a saber, los nodos institucionales, el Proyecto Pedagógico Institucional, el currículo, el modelo pedagógico dialogante de Julián de Zubiría, y finalmente la disponibilidad de recursos, acorde a la necesidad contextual de los estudiantes.
El texto se compone de una introducción, posteriormente se aborda la estrategia pedagógica en cada una de sus fases, para dar paso a los soportes teóricos basados en la sinergia de los elementos mencionados con anterioridad a la luz del modelo pedagógico de Zubiría; finalmente, se proponen las conclusiones propias del ejercicio y los logros adquiridos a partir de su ejecución.
Herramientas administrativas en procesos de emprendimiento para los estudiantes de Administración Deportiva, Fundación Universitaria del Área Andina de Bogotá.
Authors: Trujillo Rodriguez Monica Andrea 
Published: February 2022

Desde inicio de semestre se dan pautas a los estudiantes donde se les propone un proyecto de idea de negocio para emprender desde una organización deportiva o empresa enfocada en el deporte , esta idea va paralela a las temáticas del micro currículo de tal forma que a medida que se van abordando las temáticas se va desarrollando el proyecto, las temáticas apoyan el proceso cognitivo de los estudiantes, apoyadas por lecturas de libros, artículos y herramientas didácticas de tal forma que permita el entendimiento del medio administrativo del deporte y diferentes posibilidades que hay en el mundo deportivo, posibilitando a los estudiantes crear una gran idea con una misión y proyección. En el proceso administrativo de planificación, dirección, organización y control se dan todas las herramientas administrativas para que el estudiante comprenda los conceptos y los aplique en la idea de negocio para emprender a corto, mediano o largo plazo. De tal forma que los estudiantes se acerquen a una práctica empresarial desde la estructuración propia de una empresa, en el proceso los estudiantes deben crear su imagen corporativa, hacer su nombre logo y slogan y desarrollar procesos formales de estudio de competencia a través del benchmarking, harán un análisis dofa como proceso diagnóstico de lo encontraran en el sector y así establecer estrategias administrativas para que el proyecto a desarrollar sea adecuado a la comunidad y sector donde lo realizara.
Human Growth Factor/Immunoglobulin Complexes for Treatment of Myocardial Ischemia-Reperfusion Injury
Authors: Liebman Benjamin , Schwaegler Claire , Foote Andrea T. , Rao Krithika S. , Marquis Taylor , Aronshtam Alexander , Bell Stephen P. , Gogo Prospero , LaChapelle Richard R. , Spees Jeffrey L. 
Published: February 2022

Hepatocyte Growth Factor (HGF) and Fibroblast Growth Factor 2 (FGF2) are receptor tyrosine kinase agonists that promote cell survival after tissue injury and angiogenesis, cell proliferation and migration during tissue repair and regeneration. Both ligands have potential as systemic treatments for ischemia-reperfusion injury, however clinical use of HGF and FGF2 has been limited by poor pharmacokinetic profiles, i.e., their susceptibility to serum proteases, rapid clearance and short half-lives. Previously, we reported vaso- and cardioprotective protein complexes formed between HGF and polyclonal, non-specific immunoglobulin (IgG) with therapeutic efficacy in a rat model of myocardial ischemia with reperfusion (MI/R). Here, using a pre-clinical porcine MI/R model, we demonstrate human HGF/IgG complexes provide significant myocardial salvage, reduce infarct size, and are detectable in myocardial tissue 24 h after intracoronary injection. Furthermore, we show that multiple daily infusions of HGF/IgG complexes after MI do not lead to production of HGF-specific auto-antibodies, an important concern for administered biologic drugs. In experiments to identify other growth factors that non-covalently interact with IgG, we found that human FGF2 associates with IgG. Similar to human HGF/IgG complexes, FGF2/IgG complexes protected primary human cardiac endothelial cells under simulated ischemia (1% oxygen and nutrient deprivation) for 48–72 h. Molecular modeling studies suggested that FGF2 and HGF both interact with the Fc domain of IgG. Also, we tested whether an Fc-fusion protein would bind FGF2 to form complexes. By native gel electrophoretic assays and biochemical pulldowns, we found that Jagged1, a Notch1 ligand that controls stem cell self-renewal and tissue regeneration, bound FGF2 when presented as a Jagged1- Fc fusion protein. Our results suggest that human growth factor/IgG and FGF2/Fc- fusion complexes have potential to provide a biologics platform to treat myocardial ischemia-reperfusion and other forms of tissue injury.
VHPKQHR Peptide Modified Ultrasmall Paramagnetic Iron Oxide Nanoparticles Targeting Rheumatoid Arthritis for T1-Weighted Magnetic Resonance Imaging
Authors: Zhang Chunyu , Huang Wentao , Huang Chen , Zhou Chengqian , Tang Yukuan , Wei Wei , Li Yongsheng , Tang Yukuan , Luo Yu , Zhou Quan , Chen Wenli 
Published: February 2022

Magnetic resonance imaging (MRI) could be the ideal diagnostic modality for early rheumatoid arthritis (RA). Vascular cell adhesion molecule-1 (VCAM-1) is highly expressed in synovial locations in patients with RA, which could be a potential target protein for RA diagnosis. The peptide VHPKQHR (VHP) has a high affinity to VCAM-1. To make the contrast agent to target RA at an early stage, we used VHP and ultrasmall paramagnetic iron oxide (USPIO) to synthesize UVHP (U stands for USPIO) through a chemical reaction with 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide. The size of UVHP was 6.7 nm; the potential was −27.7 mV, and ther2/r1value was 1.73. Cytotoxicity assay exhibited that the cell survival rate was higher than 80% at even high concentrations of UVHP (Fe concentration 200 µg/mL), which showed the UVHP has low toxicity. Compared with no TNF-α stimulation, VCAM-1 expression was increased nearly 3-fold when mouse aortic endothelial cells (MAECs) were stimulated with 50 ng/mL TNF-α; cellular Fe uptake was increased very significantly with increasing UVHP concentration under TNF-α treatment; cellular Fe content was 17 times higher under UVHP with Fe concentration 200 µg/mL treating MAECs. These results indicate that UVHP can target overexpression of VCAM-1 at the cellular level. RA mice models were constructed with adjuvant-induced arthritis.In vivoMRI and biodistribution results show that the signal intensity of knee joints was increased significantly and Fe accumulation in RA model mice compared with normal wild-type mice after injecting UVHP 24 h. These results suggest that we have synthesized a simple, low-cost, and less toxic contrast agent UVHP, which targeted VCAM-1 for early-stage RA diagnosis and generates high contrast in T1-weighted MRI.
Postoperative Hip Center Position Associated With the Range of Internal Rotation and Extension During Gait in Hip Dysplasia Patients After Total Hip Arthroplasty
Authors: Hu Yi , Zou Diyang , Sun Qi , Jiang Mengda , Li Huiwu , Tsai Tsung-Yuan , Zhang Jingwei 
Published: February 2022

Background: Total hip arthroplasty (THA) for hip dysplasia patients is sometimes complex and compromises pathomorphological changes in these patients. However, it remains unclear whether it is preoperative deformities or postoperative structures or anatomic changes during THA that have the most remarkable correlation with the hip dynamic function during gait. The purpose of this study was to investigate this relationship and propose insights into the surgical reconstruction strategy in patients with developmental dysplasia of the hip.Methods: A total of 21 unilateral hip dysplasia patients received computed tomography scans for the creation of 3D hip models before surgery and at the last follow-up. Acetabular and femoral orientations, hip center positions, and femoral length were measured before and after THA. Hip kinematics of the operated side during gait was quantified using a dual fluoroscopic imaging technique. Pearson correlation and multiple linear regression were performed to evaluate the relationship between hip maximum range of motion in six directions and demographics characters and above hip anatomic parameters before and after THA and their changes in surgery.Results: Pearson correlation analysis found significant correlations with the gait range of motion mainly in postoperative structures, including postoperative hip center positions and acetabulum and combined anteversion. Further multiple linear regression indicated that a laterally placed hip center was significantly correlated with an increased internal rotation (R2 = 0.25, p = 0.021), which together with increased postoperative acetabulum anteversion explained 45% of external rotation decreasing (p = 0.004). A proximally placed hip center was correlated with more extension (R2 = 0.30, p = 0.010). No significant demographic characters or preoperative deformities or surgical changes were included into other multiple regression models.Conclusion: Strong correlations between postoperative structures, especially hip center positions and gait range of motion in unilateral hip dysplasia patients after THA were found. It indicated that postoperative prosthesis structures, particularly hip center positions had significant impact on the hip gait motion range and should be treated with particular caution in surgery.
A Novel Signature of Lipid Metabolism-Related Gene Predicts Prognosis and Response to Immunotherapy in Lung Adenocarcinoma
Authors: Zhang Kai , Qian Ying , Quan Xiaowei , Zhu Tengteng , Qian Biyun 
Published: February 2022

Background: Lipid metabolism disorder, a new hallmark of cancer initiation, has been involved in lung adenocarcinoma (LUAD). However, few biomarkers about lipid metabolism-related genes (LMRGs) have been developed for prognosis prediction and clinical treatment of LUAD patients.Methods: In this study, we constructed and validated an effective prognostic prediction model for LUAD patients depending on LMRGs. Subsequently, we investigated the prediction model from immune microenvironment, genomic changes, and immunotherapy.Results: Then, eleven LMRGs were identified and applied to LUAD subtyping. In comparison with the high-risk group, the low-risk group exhibited a remarkably favorable prognosis, along with a higher immune score and lower tumor purity. Moreover, the low-risk group presented higher levels of immune checkpoint molecules, lower tumor immune dysfunction and exclusion (TIDE) score and tumor mutation burden (TMB), and higher likelihood of benefiting from immunotherapy. Furthermore, the genomic changes of six LMRGs (CD79A, HACD1, CYP17A1, SLCO1B3, ANGPTL4, and LDHA) were responsible for the difference in susceptibility to LUAD by greatly influencing B-cell activation.Conclusion: Generally speaking, the LMRG model is a reliable independent biomarker for predicting adverse outcomes in LUAD patients and has the potential to facilitate risk-stratified immunotherapy.
A Bioelectrochemical System for Waste Degradation and Energy Recovery From Industrial Coffee Wastewater
Authors: Agudelo-Escobar Lina María , Cabrera Santiago Erazo , Avignone Rossa Claudio 
Published: February 2022

The primary production of coffee involves the extensive use of water resources, since it is not only used for irrigation of coffee plantations, but it is also required in large volumes for the processing of the coffee berry to obtain high quality green beans. It is calculated that for every kg of dry coffee grain produced, up to 40 L of water are consumed, and its disposal represents a significant environmental problem, since most coffee growers are small producers with no access to efficient technologies for wastewater treatment. This situation leads to these liquid wastes to be discarded untreated in natural water sources, generating environmental pollution and public health problems. Bioelectrochemical Systems (BES) have been proposed as an alternative to conventional wastewater treatments, either as a primary bioremediation strategy or for secondary wastewater treatment systems. Among BES, microbial fuel cells (MFCs) are designed to exploit the metabolic capability of andophilic microorganisms to degrade the organic matter present in the waste. Anodophilic microorganisms use electrodes as terminal electron acceptors, generating a flow of electrons that can be used in the generation of electricity. In this work, we evaluated the ability of native microbial communities to degrade the organic matter present in wastewater from the coffee agroindustry and its electrogenic potential for the co-generation of electricity was evaluated using an MFC device developed by the authors. Wastewater samples obtained at different stages of the coffee wet process were used as inoculum and feedstocks. The system was operated in fed-batch, in both open and closed-circuit conditions, for 60 days. The degree of decontamination or bioremediation of the wastewater was assessed by measurements of physicochemical parameters. For the characterization of the native microbial community, microscopic and molecular techniques were used and the electrogenic potential was established by assessing the electrochemical performance of the system. With the proposed bioelectrochemical system, a reduction of up to 70% of the initial content of organic matter of the residual water from the coffee benefit was achieved, and open circuit voltages of up to 400 mV were recorded, comparable to those reported for conventional air breathing cathode MFC.