bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining characteristics of descriptive phenomenological nursing studies: A scoping review
Authors: Shorey Shefaly , Ng Esperanza Debby 
Published: April 2022

AbstractAimTo evaluate the characteristics and methodology consistency in nursing research with descriptive phenomenological design.DesignScoping review methodology.Data sourcesThree electronic databases (CINAHL, Embase, PubMed) were systematically searched for qualitative studies with a descriptive phenomenological design published in nursing journals between January 2021 and December 2021.Review methodsQuality appraisal of each study was conducted using the Critical Appraisal Skills Programme checklist. Data were extracted and presented narratively based on research objective, design justification and consistency, theoretical framework, sampling method and sample size, data collection method, data analysis approach and presentation of findings.ResultsOne hundred and three studies were included in the review. Overall, the characteristics of the studies are mostly consistent with Husserl's phenomenology approach in terms of research objectives, the use of other theoretical frameworks, sampling and data collection methods. However, the findings revealed several inconsistencies between research design and data analysis techniques, the lack of design justification and the lack of mention of bracketing.ConclusionsApart from the need for more research and standardized guidelines to clarify the various qualitative research methods, future nurse researchers are urged to provide more methodological details when publishing a descriptive phenomenological study so that readers can examine the effectiveness and quality of the method.
The impact of the supply chain orientation fit between supply chain members: A triadic perspective
Authors: Gligor David , Feizabadi Javad , Pohlen Terrance , Maloni Michael , Ogden Jeffrey A. 
Published: April 2022

AbstractExisting literature has established supply chain orientation (SCO) as a critical enabler of supply chain management. Although SCO is predicated on alignment across supply chain members, it has primarily been examined at the individual firm level. Given this limitation, we collected triadic archival and survey data from multiple levels of the supply chain to introduce the concepts of SCO supplier fit (i.e., firm's SCO matches its supplier) and SCO customer fit (i.e., firm's SCO matches its customer). The results reveal that SCO supplier fit and SCO customer fit each positively impacts firm operational and customer performance in return on assets (ROA) and return on sales (ROS). More specifically, a firm with an SCO matching its primary upstream or downstream partners performs significantly better than a firm with a higher or lower SCO. In fact, firms with relatively more SCO than key supply chain partners perform significantly worse than those having relatively less SCO. Finally, firms with both SCO supplier fit and SCO customer fit perform better than firms with SCO supplier or customer fit alone. Ultimately, SCO alignment across the supply chain appears to be more important than the level of SCO itself.
Twenty‐year longitudinal birth cohort study of individuals diagnosed with autism spectrum disorder before seven years of age
Authors: Iwasa Mitsuaki , Shimizu Yasuo , Sasayama Daimei , Imai Miho , Ohzono Hiroko , Ueda Miori , Hara Ikuko , Honda Hideo 
Published: April 2022

BackgroundPrevious longitudinal studies have demonstrated that psychosocial outcomes for autistic adults are very limited. However, most studies are clinic‐based and liable to selection bias and major methodological problems.MethodsWe conducted a long‐term follow‐up study with 278 autistic individuals from our previous birth cohort study comprising 31,426 individuals. All participants were born in northern Yokohama between 1988 and 1996, diagnosed with autism spectrum disorder (ASD) by age seven, and followed up over 20 years. A total of 170 consented to participate in the study. Outcome measures included overall social functioning based on work, independent living, and friendships. Moreover, the time‐use data concerning social participation and activities of daily living were compared with the general population.ResultsPsychosocial outcomes in adulthood (average age 25) were very good in 13.7%, good in 25.0%, fair in 31.0%, poor in 25.6%, and very poor in 4.8% of the participants. The majority participated in major life areas of and work and education (96.4%), sports (82.1%), and recreational activities and/or hobbies (98.8%). The proportion of participants who engaged in housework and self‐care was comparable to that of the general population. Participants with IQ < 50 at age five had significantly worse outcomes than those with higher IQ; however, for those with IQ ≥ 50, outcomes were not significantly associated with IQ levels.ConclusionsAlthough complete independence was difficult to accomplish, many autistic adults engaged in organized community activities and housework and self‐care. Time‐use survey could offer a variety of data in investigating psychosocial outcomes of ASD cross‐culturally.
The psychological consequences of androgenetic alopecia: A systematic review
Authors: Aukerman Erica L. , Jafferany Mohammad 
Published: April 2022

AbstractIntroductionAndrogenetic alopecia is the most common cause of hair loss in both males and females. In a society that places significant value on hair and associates it with attractiveness, a lack there of can have damaging psychological consequences. The psychosocial impact of hair loss is often overlooked due to the medically benign nature of offending conditions. Addressing the psychological aspects of androgenetic alopecia can improve holistic patient care and patient outcomes.MethodsA search was conducted in PubMed using the following search strategy: androgenetic alopecia AND anxiety OR depression OR psychological OR psychosocial OR self‐esteem. Studies were excluded if they focused on any other type of alopecia or were published in a language other than English.ResultsA total of 13 studies were retained after the initial search process. The included studies date from 1992 to 2021. They all conclude that androgenetic alopecia serves as a significant psychosocial stressor in the lives of those affected. It impairs quality of life according to multiple measures.ConclusionThe data examined from these studies shed light on the increased need to attend to the psychosocial comorbidity associated with androgenetic alopecia. These hair‐loss patients often present to dermatology clinics to seek treatment but would also benefit from psychological support.
Barriers and facilitators to the implementation and adoption of improvement coaching: A qualitative evidence synthesis
Authors: Rushton Sharron , Lewinski Allison A. , Hwang Soohyun , Zullig Leah L. , Ball Ricks Katharine A. , Ramos Katherine , Gordon Adelaide , Ear Belinda , Ballengee Lindsay A. , Brahmajothi Mulugu V. , Moore Thomasena , Blalock Dan V. , Williams John W. , Cantrell Sarah E. , Gierisch Jennifer M. , Goldstein Karen M. 
Published: April 2022

AbstractBackgroundHealthcare organisations and teams perform improvement activities to facilitate high‐quality healthcare. The use of an improvement coach who provides support and guidance to the healthcare team may facilitate improvement activities; however, no systematic review exists on the facilitators and barriers to implementing an improvement coach.AimsWe conducted a qualitative evidence synthesis to examine the facilitators and barriers to the implementation of improvement coaching.MethodsWe searched MEDLINE®, Embase and CINAHL. The final search was in March 2021. The screening eligibility criteria included the following: interdisciplinary team receiving the coaching, improvement coaching, designs with a qualitative component and primary purpose of evaluating practice facilitation in OECD countries. An ecologically‐informed consolidated framework for implementation research (CFIR) served as the framework for coding. Patterns of barriers and facilitators across domains were identified through matrix analysis. Risk of bias was assessed using Critical Appraisal Skills Program. PRISMA reporting guidelines served as a guide for reporting this review.ResultsNineteen studies with a qualitative component met the inclusion criteria. Four themes of barriers and facilitators crossed multiple CFIR domains: adaptability (e.g. making adjustments to the project; process, or approach); knowledge and skills (e.g. understanding of content and process for the project); engagement (e.g. willingness to be involved in the process) and resources (e.g. assets required to complete the improvement process).ConclusionImprovement coaching is a complex intervention that influences the context, healthcare team being coached and improvement activities. Improvement coaches should understand how to minimise barriers and promote facilitators that are unique to each improvement project across the domains. Limitations of the study are related to the nature of the intervention including potential publication bias given quality improvement focus; the variety of terms similar to improvement coaching or selection of framework.
Recent advances in memory consolidation and information processing during sleep
Authors: Hoedlmoser Kerstin , Peigneux Philippe , Rauchs Géraldine 
Published: April 2022

SummaryIncreasingly studied in a systematic manner since the 1970s, the cognitive processes of the brain taking place during sleeping periods remain an important object of scrutiny in the scientific community. In particular, sleep has been demonstrated to play a significant role for learning and memory consolidation processes, and sleep scientists have started unravelling its underlying neurophysiological mechanisms. However, sleep remains a multidimensional phenomenon, and many questions remain left open for future research. In this selective review article, we address recent advances in particular domains in which sleep research has further progressed in the past decade. We highlight the developmental trajectory of sleep‐dependent learning and memory consolidation processes, from their development in childhood to their potential impairments in ageing, and the nature and extent of our capabilities for information processing, learning, and memory reinforcement during sleep.
Molecular interactions between the intestinal microbiota and the host
Authors: Hertli Salomé , Zimmermann Petra 
Published: April 2022

AbstractThe intestine is the most densely colonized region of the body, inhabited by a diverse community of microbes. The functional significance of the intestinal microbiota is not yet fully understood, but it is known that the microbiota is implicated in numerous physiological processes of the host, such as metabolism, nutrition, the immune system, and regulation of behavior and mood. This article reviews recent findings on how bacteria of the intestinal microbiota interact with the host.Microbiota‐microbiota and microbiota‐host interactions are mediated by direct cell contact and by metabolites either produced by bacteria or produced by the host or the environment and metabolized by bacteria. Among them are short‐chain fatty, including butyrate, propionate, and acetate. Other examples include polyamines, linoleic acid metabolites, tryptophan metabolites, trimethylamine‐N‐oxide, vitamins, and secondary bile acids. These metabolites are involved in regulating the cell cycle, neurobiological signaling, cholesterol and bile acid metabolism, immune responses, and responses to antioxidants. Understanding the host‐microbiota pathways and their modulation will allow the identification of individualized therapeutic targets for many diseases. This overview helps to facilitate and promote further research in this field.
New horizons in the politics of water governance
Authors: Challies Edward , Tadaki Marc 
Published: April 2022

AbstractThe governance of water encapsulates fundamental choices about how to mediate struggles between core values and interests across society. This Special Issue illustrates how New Zealand is driving frontiers of experimentation in water governance as well as theoretical innovation in water governance research. This scholarship pushes forward global thinking about the epistemological politics of water, transformations in decision‐making and the roles of non‐state actors in water politics. This research carries forward the longstanding interest of New Zealand geographers in freshwater politics, generating analytical insights of global significance and practical relevance.
Epithelial–mesenchymal transition and cancer stem cells: A route to acquired cisplatin resistance through epigenetics in HNSCC
Authors: Lima de Oliveira Julia , Moré Milan Thaís , Longo Bighetti‐Trevisan Rayana , Fernandes Roger Rodrigo , Machado Leopoldino Andréia , Oliveira de Almeida Luciana 
Published: April 2022

AbstractChemoresistance is associated with tumor recurrence, metastases, and short survival. Cisplatin is one of the most used chemotherapies in cancer treatment, including head and neck squamous cell carcinoma (HNSCC), and many patients develop resistance. Here, we established cell lines resistant to cisplatin to better understand epigenetics and biological differences driving the progression of HNSCC after treatment. Cisplatin resistance was established in CAL‐27 and SCC‐9 cell lines. Gene expression of HDAC1, HDAC2, SIRT1, MTA1, KAT2B, KAT6A, KAT6B, and BRD4 indicated the cisplatin activates the epigenetic machinery. Increases in tumor aggressiveness were detected by BMI‐1 and KI‐67 in more resistant cell lines. Changes in cellular shape and epithelial–mesenchymal transition (EMT) activation were also observed. HDAC1 and ZEB1 presented an opposite distribution with down‐regulation of HDAC1 and up‐regulation of ZEB1 in the course of chemoresistance. Up‐regulation of ZEB1 and BMI‐1 in patients with HNSCC is also associated with a poor response to therapy. Cancer stem cells (CSC) population increased significantly with chemoresistance. Down‐regulation of HDAC1, HDAC2, and SIRT1 and accumulation of Vimentin and ZEB1 were observed in the CSC population. Our results suggest that in the route to cisplatin chemoresistance, epigenetic modifications can be associated with EMT activation and CSC accumulation which originate more aggressive tumors.
SlMIR164A regulates fruit ripening and quality by controlling SlNAM2 and SlNAM3 in tomato
Authors: Lin Dongbo , Zhu Xiaoen , Qi Binglin , Gao Zhong , Tian Peng , Li Ziwei , Lin Zeteng , Zhang Yongxia , Huang Tengbo 
Published: April 2022

SummaryMiRNAs are important posttranscriptional regulators of plant development. Many miRNAs, such as the conserved miR164 species, are encoded by families of MIRNA genes, but the specific roles of individual MIRNA genes are largely undefined. Here, we characterize the functions and regulatory mechanisms of SlMIR164A, one of the primary genes of Sly‐miR164, in tomato. We show that SlMIR164A is preferentially expressed at late stages of fruit development and plays a vital role in controlling fruit ripening and quality. Loss of function of SlMIR164A by CRISPR/Cas9‐mediated mutagenesis results in accelerated fruit ripening and enhanced chloroplast development, which leads to altered sugar and organic acid contents and affects the nutritional quality of fruits. We also show that SlMIR164A modulates fruit ripening and quality through specific target genes, SlNAM2 and SlNAM3, which control key regulators of chloroplast function and fruit ripening processes. MIR164 genes have been shown to play conserved roles in regulating organ ageing, such as leaf senescence and fruit ripening, in a variety of plants, but whether and how their family members in tomato exert the same function remain to be elucidated. Our results reveal a previously undiscovered role of SlMIR164A in ripening control, which will further our understanding of the actions of MIR164 family, as well as the mechanisms of fruit ripening and quality control in tomato. Moreover, as loss of SlMIR164A exhibits minor impacts on organ morphology, our results can be leveraged in tomato breeding for specific manipulation of fruit ripening and quality to facilitate tomato improvement in agriculture.
Effects of specific collagen peptide supplementation combined with resistance training on Achilles tendon properties
Authors: Jerger Simon , Centner Christoph , Lauber Benedikt , Seynnes Olivier , Sohnius Tim , Jendricke Patrick , Oesser Steffen , Gollhofer Albert , König Daniel 
Published: April 2022

The purpose of this study was to investigate the effect of specific collagen peptides (SCP) combined with resistance training (RT) on changes in tendinous and muscular properties. In a randomized, placebo‐controlled study, 40 healthy male volunteers (age: 26.3 ± 4.0 years) completed a 14 weeks high‐load resistance training program. One group received a daily dosage of 5g SCP while the other group received 5g of a placebo (PLA) supplement. Changes in Achilles tendon cross‐sectional area (CSA), tendon stiffness, muscular strength, and thickness of the plantar flexors were measured. The SCP supplementation led to a significantly (p = 0.002) greater increase in tendon CSA (+11.0%) compared with the PLA group (+4.7%). Moreover, the statistical analysis revealed a significantly (p = 0.014) greater increase in muscle thickness in the SCP group (+7.3%) compared with the PLA group (+2.7%). Finally, tendon stiffness and muscle strength increased in both groups, with no statistical difference between the groups. In conclusion, the current study shows that the supplementation of specific collagen peptides combined with RT is associated with a greater hypertrophy in tendinous and muscular structures than RT alone in young physically active men. These effects might play a role in reducing tendon stress (i.e., deposition of collagen in load‐bearing structures) during daily activities.
Blood donor eligibility criteria for medical conditions: A BEST collaborative study
Authors: Jacquot Cyril , Tiberghien Pierre , van den Hurk Katja , Ziman Alyssa , Shaz Beth , Apelseth Torunn Oveland , Goldman Mindy ,   The Biomedical Excellence for Safer Transfusion (BEST) Collaborative
Published: April 2022

AbstractBackground and ObjectivesDonor eligibility questions and criteria for medical conditions vary between blood centres, suggesting that they are based more on local regulations or experience, rather than on published data, which are limited. As the donor population ages, medical conditions become more common. We assessed donor health assessment criteria at blood centre members of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative. Our aim was to compare eligibility criteria and determine their underlying basis.Materials and MethodsA REDCap survey was sent to blood centre participants, based on medical conditions of greatest interest suggested by the Donor Studies Team of the BEST Collaborative. Participants were asked about current donor health assessment questions, deferral criteria and the basis for their deferral policy (donor risk, recipient risk or both) for 20 medical conditions.ResultsComplete responses were received from 26 blood donor centres (24 separate responses) representing a combination of hospital‐based centres, large regional centres and community/national blood centres in 14 different countries. Most centres specifically ask about heart and lung conditions, whereas fewer than half inquire about kidney, gastrointestinal or neurological conditions. North American blood centres tended to be less restrictive, while regulatory restrictions are more prevalent in Europe. Most participants felt that the criteria were based on regulatory requirements or experience, rather than on published data.ConclusionThere is considerable variability in criteria by region. Ideally, criteria would be more evidence‐based rather than based on regulatory requirements or experience. Deferral criteria must balance donor and recipient safety and maintain an adequate blood supply.
Real-world visual outcomes of cataract surgery based on population-based studies: a systematic review
Authors: Han Xiaotong , Zhang Jiaqing , Liu Zhenzhen , Tan Xuhua , Jin Guangming , He Mingguang , Luo Lixia , Liu Yizhi 
Published: April 2022

Background/aimsQuantity of cataract surgery has long been an important public health indicator to assess health accessibility, however the quality of care has been less investigated. We aimed to summarise the up-to-date evidences to assess the real-world visual outcomes after cataract surgery in different settings.MethodsA systematic review was undertaken in October 2021. Population-based cross-sectional and longitudinal studies reporting vision-related outcomes after cataract surgery published from 2006 onward were included. A meta-analysis was not planned.ResultsTwenty-six cross-sectional studies from low-income and middle-income countries (LMICs) and five cross-sectional studies from high-income countries (HICs) were included. The proportions of participants with postoperative presenting visual acuity (VA) ≥0.32 (20/60) were all over 70% in all HICS studies, but mostly below 70% in LMICS studies, ranging from 29.9% to 80.5%. Significant difference in postoperative VA was also observed within countries. The leading causes for postoperative visual impairment (defined mostly as presenting VA <20/60) mainly included refractive error, ocular comorbidities and surgical complications including posterior capsule opacification, except for one study in Nigeria wherein the leading cause was aphakia. Only four population-based cohort studies were included with 5–20 years of follow-up time, generally demonstrating no significant changes in postoperative visual outcomes during the follow-up.ConclusionsWe observed large inequality in the visual outcomes and principal causes of visual impairment after cataract surgery among different countries and regions. Structured quality control and enhancement programmes are needed to improve the outcomes of cataract surgery and reduce inequality.