bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uterine tumours with myogenic differentiation harbouring SRF::RELA fusions
Authors: Li Yimin , Huang Dan , Bi Rui , Yao Qianlan , Ge Ling , Yu Lin , Zhou Xiaoyan , Yang Wentao 
Published: July 2022

AimsIn 2017, a subset of cellular variants of myofibroma and myopericytoma with a smooth muscle‐like immunophenotype and harbouring recurrent SRF::RELA gene fusions was reported. Although the anatomical distribution was found to be quite broad, no tumours with these gene fusions in the female reproductive system have been illustrated to date.Methods and resultsHerein, we report the histological and immunophenotypical features of three uterine tumours with SRF::RELA gene fusions. Microscopically, all three tumours were composed of cellular oval to spindle cells arranged in intersecting fascicles with variable amounts of collagen and a rich capillary network. Mitotic figures were scant. Regarding immunohistochemistry, diffuse staining for desmin, oestrogen receptor and progesterone receptor was observed in all three cases. The first case exhibited focal staining for h‐caldesmon, whereas the latter two cases had diffuse staining. Furthermore, SRF::RELA rearrangement was observed in all three cases by using next‐generation sequencing (NGS). Follow‐up, ranging from 11 to 15 months, was available for these three patients, all of whom were well without evidence of disease.ConclusionsIn conclusion, we reported a special group of uterine neoplasms with myogenic differentiation harbouring SRF::RELA rearrangement. Although the follow‐up time was limited, morphological characteristics and other studies with follow‐up data supported that this type of uterine neoplasm appeared to behave in a benign manner. Further studies with longer follow‐up are needed to clarify the biological nature of this particular type of uterine tumour.
Response to a crisis and applicant attraction: Signaling employer brand personality and organizational trust through warm and competent COVID‐19 responses
Authors: Kanwal Hira , Van Hoye Greet , Schollaert Eveline 
Published: July 2022

AbstractThis paper investigates how organizations' response to a crisis such as the COVID‐19 pandemic affects their employer attractiveness. Based on signaling theory, we argue that a COVID‐19 response can signal an organization's employer brand personality, positively affecting applicant attraction. We conducted two experimental studies with employed and unemployed UK participants through Prolific Academic. Both studies indicate that a warm COVID‐19 response leads to the highest employer attractiveness and job pursuit intentions, although a competent response was still more attractive than no response. Moreover, applicants use the warm and competent responses as signals of organizational warmth and competence respectively, building higher organizational trust. Limited support for the moderating role of applicants' personality was found. Implications during and beyond COVID‐19 are discussed.
Reliability and validity of the Turkish version of the Oral Health Literacy Assessment Task: Pathways between parental oral health literacy and oral health consequences in children
Authors: Buldur Burak , Oguz Esra 
Published: July 2022

AbstractBackgroundParental oral health literacy (OHL) is a determinant of oral health behavior and oral health status of children.AimTo delineate the pathways between parental OHL and oral health consequences in children and to validate the Turkish version of the Oral Health Literacy Assessment Task (TOHLAT‐P).DesignThis cross‐sectional study was conducted with 315 parent–child dyads. The TOHLAT‐P was psychometrically evaluated. Item analysis was performed to determine the reliability of the TOHLAT‐P. Construct validity was tested by comparing a commonly used instrument using Pearson's product–moment correlation coefficients. A path model was developed to evaluate associations between parental OHL and oral health consequences in children. The model consisted of five endogenous variables (parental oral health behaviors, children's oral health behaviors, children's dental anxiety, dental caries, and oral health‐related quality of life [OHRQoL]) and one exogenous variable (parental OHL). A path analysis was used to test the compatibility of the conceptual model, with a statistical significance of p < .001.ResultsThere was a statistically significant association between parental oral health behaviors and children's oral health behaviors, and between dental caries and OHRQoL. The variable most directly affected by parental OHL was parental oral health behaviors, whereas the variable most indirectly affected by parental OHL was children's oral health behaviors.ConclusionsThe path analysis revealed significant associations between parental and children's oral health behaviors, and between dental caries and OHRQoL. Understanding these pathways is necessary to establish strategies to improve children's oral health. The TOHLAT‐P will be useful for future assessments of Turkish children.
Subtypes of work engagement in frontline supporting nurses during COVID‐19 pandemic: A latent profile analysis
Authors: Yin Yizhen , Lyu Mengmeng , Zuo Man , Yao Shuyu , Li Hui , Li Juan , Zhang Jie , Zhang Jingping 
Published: July 2022

AbstractAimThe aim was to examine the subgroups of work engagement in frontline nurses during the COVID‐19 pandemic.BackgroundThe pandemic may affect the work engagement of nurses who have direct contact with infected patients and lead to a poor quality of care. Identifying classification features of work engagement and tailoring interventions to support frontline nurses is imperative.DesignThis study utilized a cross‐sectional study design.MethodsThree hundred fifty‐five nurses were enrolled in this cross‐sectional study from 14 February to 15 April 2020. A latent profile analysis was performed to identify classification features of work engagement. Multiple logistic regression analyses were used to examine predictors of profile membership.ResultsA four‐profile model provided the best fit. The four profiles were titled ‘low work engagement’ (n = 99), ‘high vigour‐low dedication and absorption’ (n = 58), ‘moderate work engagement’ (n = 63) and ‘high work engagement’ (n = 135). A regression analysis suggested that young nurses and nurses who were the only children of their family were more likely to be in the ‘low work engagement’ and ‘high vigour‐low dedication and absorption’ groups.ConclusionThis study highlights the importance of tailoring interventions for frontline supporting nurses by considering their distinct work engagement patterns, especially during the COVID‐19 pandemic, to improve the promotion of work satisfaction and quality of care.ImpactThis was the first study to explore the latent profiles of work engagement in frontline nurses during the COVID‐19 pandemic. Over 40% of nurses were in the ‘low work engagement’ and ‘high vigour‐low dedication and absorption’ groups and reported low levels of work engagement. Understanding different patterns of work engagement in frontline nurses can help nursing managers provide emotional, material and organizational support based on the features of each latent profile, which may improve the quality of care and patient safety.
Assessment of melanoma thickness based on dermoscopy images: an open, web‐based, international, diagnostic study
Authors: Polesie S. , Gillstedt M. , Kittler H. , Rinner C. , Tschandl P. , Paoli J. 
Published: July 2022

AbstractBackgroundPreoperative assessment of whether a melanoma is invasive or in situ (MIS) is a common task that might have important implications for triage, prognosis and the selection of surgical margins. Several dermoscopic features suggestive of melanoma have been described, but only a few of these are useful in differentiating MIS from invasive melanoma.ObjectiveThe primary aim of this study was to evaluate how accurately a large number of international readers, individually as well as collectively, were able to discriminate between MIS and invasive melanomas as well as estimate the Breslow thickness of invasive melanomas based on dermoscopy images. The secondary aim was to compare the accuracy of two machine learning convolutional neural networks (CNNs) and the collective reader response.MethodsWe conducted an open, web‐based, international, diagnostic reader study using an online platform. The online challenge opened on 10 May 2021 and closed on 19 July 2021 (71 days) and was advertised through several social media channels. The investigation included, 1456 dermoscopy images of melanomas (788 MIS; 474 melanomas ≤1.0 mm and 194 >1.0 mm). A test set comprising 277 MIS and 246 invasive melanomas was used to compare readers and CNNs.ResultsWe analysed 22 314 readings by 438 international readers. The overall accuracy (95% confidence interval) for melanoma thickness was 56.4% (55.7%–57.0%), 63.4% (62.5%–64.2%) for MIS and 71.0% (70.3%–72.1%) for invasive melanoma. Readers accurately predicted the thickness in 85.9% (85.4%–86.4%) of melanomas ≤1.0 mm (including MIS) and in 70.8% (69.2%–72.5%) of melanomas >1.0 mm. The reader collective outperformed a de novo CNN but not a pretrained CNN in differentiating MIS from invasive melanoma.ConclusionsUsing dermoscopy images, readers and CNNs predict melanoma thickness with fair to moderate accuracy. Readers most accurately discriminated between thin (≤1.0 mm including MIS) and thick melanomas (>1.0 mm).
Multiple magnet ingestion in children: A problem on the rise
Authors: Seguier‐Lipszyc Emmanuelle , Samuk Inbal , Almog Anastasia , Silbermintz Ari , Kravarusic Dragan 
Published: July 2022

AimIngestion of multiple magnets is increasing these last 15 years in children. They have resulted in numerous reports of serious gastrointestinal complications such as bowel obstruction, ischaemia, necrosis, perforation and fistula formation and even led to death. The increasing number of world‐wide reports of complications secondary to magnet ingestion and a frequently delayed diagnosis point to a lack of awareness about these risks among medical care‐givers in our country and parents in general.MethodsWe reviewed retrospectively all cases of multiple magnet ingestion that required a gastro‐intestinal or surgical procedure for removal from 2009 to 2020.ResultsFive children underwent gastroscopy removal and three colonoscopy removal of the magnets. Five patients required surgical (laparotomy or laparoscopy) removal of multiple magnets with intestinal perforations.ConclusionsWe propose an updated management algorithm for multiple magnet ingestion to highlight awareness among primary physicians and parents of the presenting circumstances and symptoms as well as the potential complications associated with multiple magnet ingestion.
Quality assurance in health professions education: Role of accreditation and licensure
Authors: Amaral Eliana , Norcini John 
Published: July 2022

AbstractObjectiveThe aim of this paper is to provide an overview of the major quality assurance strategies, accreditation and licensure, in health professions education. It explores the nature of these regulatory processes using Brazil and the United States as examples because these large systems are at different ends of the developmental continuum. For each, it describes the tensions that arise, offers a critical synthesis of the evidence and maps out future directions.ResultsGiven wide variability among operating medical schools in curricular design, length of study, resources and facilities for clinical training and supervision, the nature of regulatory bodies varies considerably. Nonetheless, they share tensions related purpose and process including quality assurance versus quality improvement, outcomes versus process and continuous versus episodic evaluations and assessments. Clear evidence of effectiveness, especially for accreditation, is scarce and difficult to obtain, particularly as it relates to health outcomes.ConclusionsRegulatory processes need to be built around clear definitions of the goals for each stage of professional development, the current movement towards competency‐based education and the variable durations of medical education. These changes must motivate revisions in the content and process of programmes for accreditation and licensure, complimentary efforts towards quality of care, and stimulate a significant research effort.
Transcriptome analyses unveiled differential regulation of AGO and DCL genes by pepino mosaic virus strains
Authors: Alcaide Cristina , Donaire Livia , Aranda Miguel A. 
Published: July 2022

AbstractPepino mosaic virus (PepMV) is a single‐stranded (ss), positive‐sense (+) RNA potexvirus that affects tomato crops worldwide. We have described an in planta antagonistic interaction between PepMV isolates of two strains in which the EU isolate represses the accumulation of the CH2 isolate during mixed infections. Reports describing transcriptomic responses to mixed infections are scant. We carried out transcriptomic analyses of tomato plants singly and mixed‐infected with two PepMV isolates of both strains. Comparison of the transcriptomes of singly infected plants showed that deeper transcriptomic alterations occurred at early infection times, and also that each of the viral strains modulated the host transcriptome differentially. Mixed infections caused transcriptomic alterations similar to those for the sum of single infections at early infection times, but clearly differing at later times postinfection. We next tested the hypothesis that PepMV‐EU, in either single or mixed infections, deregulates host gene expression differentially so that virus accumulation of both strains gets repressed. That seemed to be the case for the genes AGO1a, DCL2d, AGO2a, and DCL2b, which are involved in the antiviral silencing pathway and were upregulated by PepMV‐EU but not by PepMV‐CH2 at early times postinfection. The pattern of AGO2a expression was validated by reverse transcription‐quantitative PCR in tomato and Nicotiana benthamiana plants. Using an N. benthamiana ago2 mutant line, we showed that AGO2 indeed plays an important role in the antiviral defence against PepMV, but it is not the primary determinant of the outcome of the antagonistic interaction between the two PepMV strains.
Spinal disorders and mastication: The potential relationship between adolescent idiopathic scoliosis and alterations of the chewing patterns
Authors: Piancino Maria Grazia , Tortarolo Alessandro , Macdonald Francesco , Garagiola Umberto , Nucci Ludovica , Brayda‐Bruno Marco 
Published: July 2022

AbstractObjectiveTo evaluate mastication in a group of patients with adolescent idiopathic scoliosis (AIS) with a control group, by means of the prevalence of reverse chewing cycles (RCCs).Material and MethodsThis study included a group of patients (N = 32; F = 24; M = 8; mean age ± SD = 14 ± 3 years) with a confirmed diagnosis of AIS and a group of control subjects (N = 32; F = 24; M = 8; mean age ± SD = 13 ± 6 years) without spinal disorders. Mastication was recorded with both a hard and a soft bolus, following a standardized protocol, and the prevalence of RCCs was compared between the groups.ResultsThe prevalence of RCCs was significantly higher in the AIS group, with both a soft and a hard bolus, compared to the control group (P < .001).ConclusionThe results of this study indicate that the presence of AIS influences mastication, one of the main functions of the stomatognathic system. A multidisciplinary approach to these patients may be relevant in providing the best possible treatment outcomes.
La syntopie
Authors: Jakubczuk Renata , Wołowski Witold 
Published: July 2022

RésuméLe présent article – focalisé sur l’écriture théâtrale de deux auteurs belges (Paul Willems et Paul Emond) – se compose de deux volets. D’abord, il propose la notion de syntopie, terme désignant une sélection (synthèse spatiale) de lieux, d’objets, de personnes et de processus pour/dans la composition d’une œuvre fictionnelle, opération qui peut correspondre, dans certains cas, à la cartographie cognitive d’un auteur déterminé. Dans un second temps, l’article analyse les deux pièces choisies (Il pleut dans ma maison et Il y a des anges qui dansent sur le lac), en mettant en évidence les analogies frappantes qu’elles présentent au niveau de l’arrangement spatial.
Experience of ethical dilemmas among professionals working in pediatric transplantation: An international survey
Authors: Arslan Zainab , Hennessy Jack , McCulloch Mignon I. , Dipchand Anne I. , Lefkowitz Debra S. , Marks Stephen D. 
Published: July 2022

AbstractBackgroundProfessionals working in pediatric transplantation commonly encounter complex ethical dilemmas. Most ethical research in transplantation is related to adult practice. We aimed to gain insight into ethical issues faced by transplant professionals when dealing with pediatric transplant recipients.MethodsA two‐stage study was designed; the first part was a questionnaire completed by 190 (80%) members of the International Pediatric Transplant Association (IPTA) from over 30 different countries. This was followed by a multidisciplinary focus group that explored the preliminary data of the survey.ResultsA total of 38% (56 of 149) respondents of the questionnaire had experienced an ethical issue between 2016 and 2018. Surgeons were more likely to have encountered an ethical issue as compared with physicians (60% vs. 35.7%, p = .035). Clinicians from Europe were more likely to have experienced an ethical issue in living organ donation compared with those from North America (78.9% vs. 52.5%, p = .005), with common ethical concerns being psychosocial evaluation and follow‐up care of donors. The focus group highlighted the importance of a multidisciplinary approach to ethical issues.ConclusionThe results of this study can direct future research into pediatric transplantation ethics with the aim of producing educational resources, policies, and ethical guidelines.
Probabilistic selling in vertically differentiated markets: The role of substitution
Authors: He Ying , Rui Huaxia 
Published: July 2022

This paper studies two fundamental questions regarding probabilistic selling in vertically differentiated markets: When is it profitable and how does one design it optimally? For the first question, we identify an important but overlooked economic mechanism driving probabilistic selling in vertically differentiated markets: the convexity of consumer preferences. In stark contrast to the literature finding that probabilistic selling is never profitable except in the presence of certain capacity constraint or consumer bounded rationality, we find that with many alternative utility functions capable of representing convex preference, probabilistic selling is always profitable. For the second question, we study the optimal strategy of probabilistic selling, including the design and price of the probabilistic good and the prices of the component goods. We show that under some technical conditions, the optimal price of the high‐quality component good increases while the optimal price of the low‐quality component good decreases upon the introduction of probabilistic selling, thereby increasing the market coverage and the economic efficiency without launching an actual new product line. To further illustrate the design of probabilistic selling, we use an example based on the canonical utility function, which is widely used in the economics literature on vertical product differentiation. We derive a closed‐form solution to the problem of optimal probabilistic selling. We also take advantage of the analytical tractability of the canonical utility to further explore the design of multiple probabilistic goods.
Retrospective evaluation of jugular venous blood variables and mortality in critically ill hospitalized cats
Authors: Donati Pablo A. , Rabelo Rodrigo Cardoso , Araos Joaquin , Tunesi Marcela , Mouly Javier , Londoño Leonel , Jensen Mario , Dubin Arnaldo 
Published: July 2022

AbstractObjectiveTo evaluate clinicopathological variables associated with hospital mortality in critically ill cats with compromised hemodynamics and tissue hypoperfusion.DesignRetrospective observational study.SettingPrivate referral center.AnimalsFifty‐seven critically ill cats with compromised hemodynamics or tissue hypoperfusion.InterventionsNone.Measurements and Main ResultsThe electronic medical records were searched for all cats admitted from June 2014 to November 2020. Cats were included in the study if the medical records clearly identified the presence of compromised hemodynamics and tissue hypoperfusion. Blood samples were obtained by percutaneous puncture of the external jugular vein, and blood gases, electrolytes, L‐lactate concentration, and glucose were measured by a point‐of‐care analyzer. A predictive logistic regression model for mortality was performed. A total of 57 cats were ultimately included in the study. Thirty‐five cats died. Eighteen of them were euthanized because of the severity of illness, and 17 died naturally. Twenty‐two cats were discharged alive from the hospital. After adjusting for the Acute Patient Physiologic and Laboratory Evaluation (APPLE) fast score and disease category, jugular venous partial pressure of oxygen (Pvjo2) and HCT at admission were independent predictors of hospital mortality (HCT: odds ratio [OR], 0.763, 95% confidence interval [CI]: 0.625–0.930; P = 0.008; Pjvo2: OR, 0.858; 95% CI: 0.749–0.984; P = 0.029). The association of these variables with mortality was maintained after conducting a sensitivity analysis and excluding cats that died by euthanasia.ConclusionsIn cats with hemodynamic instability and tissue hypoperfusion, HCT and Pvjo2 behaved as independent predictors of mortality. Both variables seem to reflect the magnitude of oxygen debt and tissue hypoperfusion.
Removal of nitrate in raw water using a vertical roughing filter with an external carbon source
Authors: Mohobane Lekhooa , Mutsvangwa Crispen , Asante Yaw Owusu 
Published: July 2022

AbstractHigh nitrate concentration in water endangers health to both humans and livestock. The aim of this research was to investigate the efficacy of a roughing filter enhanced by an external carbon source in removing nitrate in raw water. Two upward vertical roughing filters in series were used—a vertical roughing filter with ethanol as a carbon source (VRFwt) and a vertical roughing filter without a carbon source (VRFwo). The average nitrate removal efficiency in a VRFwt was 88%, 70% and 83%, at carbon:nitrogen ratios (C/N ratio) of 1.05, 1.08 and 1.1, respectively. The average chemical oxygen demand (COD) removal efficiency in the VRFwt was 75%, 43% and 46% at C/N ratios of 1.05, 1.08 and 1.1, respectively. The total average reduction of dissolved oxygen (DO) in the VRFwt at C/N ratios of 1.05, 1.08 and 1.1 was 42%, 54% and 51%, respectively, while the drop in the VRFwo was 17%, 18% and 17%. The VRFwt showed a high potential for removing nitrate in raw water. Therefore, when the VRFwt is applied at large scale, it would improve access to water sources that were previously declared unacceptable by many water utilities due to excessive nitrate concentrations.