bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fox Eye Effect Using a Transcutaneous Mini-Eyebrow Tail Lift
Authors: Borba André , Rodrigues Matheus 
Published: March 2022

The eyebrow position is a determining factor related to facial expression, especially concerning the anatomical relationship of the eyebrow with the eyelid. The changing position of the eyebrows with aging influences the individual’s expression and can give negative emotions such as loss of vitality, sadness, and tiredness, and influence facial beauty. Numerous procedures are available to the surgeon to prevent the eyebrows from falling after upper blepharoplasty or lift them in isolation. Despite the various surgical techniques undertaken to manage the eyebrow, conventional approaches are usually more aggressive procedures involving extensive skin resection at the hairline or scalp, endoscopic elevation, and temporal and coronal approaches. Given the growing search for less aggressive procedures that patients better tolerate, this study aims to describe a less invasive variation of the Castañares technique, focused on the elevation of the eyebrow’s tail, which may or may not be associated with blepharoplasty, the Surgical Fox Eye. The technique removes an ellipse of skin above the distal third of the eyebrow close to the hair bulbs and then sutures with a direct elevation of the eyebrow tail. The technique described is ideal for several cases, as it presents predictable and satisfactory clinical outcomes as to the patients’ expectations. It also presents easy healing with extensive durability with minimal chance of complications. Level of evidence: Level V—Opinions of respected authorities, based on clinical experience, descriptive studies, or reports of expert committees.
Thermal and mechanical characterization of alumina modified multifunctional novolac epoxy nanocomposites
Authors: Mishra Archana , Shukla Moksh , Shukla Manoj K , Srivastava Deepak , Nagpal Arun K 
Published: March 2022

The multifunctional novolac epoxy/Al2O3 nanocomposites were fabricated by high-speed mechanical mixing of epoxy resin with varying concentration of nano Al2O3 (0–5 wt%) of particle size 13 nm for 30 min, followed by curing with triethylenetetramine (TETA) at 110°C for 1 h and post-curing at 80°C for 5 h. The fabricated nanocomposite samples were characterized for mechanical properties (viz., tensile strength, elongation-at-break, impact strength, toughness, and hardness shore D), thermal stability, and fire retardancy. It was observed that the 3 wt% nano-Al2O3 containing sample showed significant enhancement in the tensile strength, elongation-at-break, impact strength, hardness shore D, thermal stability, and fire retardancy compared to the neat epoxy sample. The Differential Scanning calorimetry (DSC) confirmed the 3-D curing reaction between TETA and nano-alumina modified epoxy and neat epoxy samples. The reactivity effect of alumina towards resin was investigated by Fourier Transform Infrared (FTIR) spectroscopy. The morphological studies of nanocomposite samples were investigated by Scanning Electron Microscopy (SEM) to justify the enhancement of mechanical properties via dispersion of nanoparticles.
Multidisciplinary support for ethics deliberations during the first COVID wave
Authors: Lombart Bénédicte , Moïsi Laura , Bellamy Valérie , Landolfini Valérie , Manifacier Marie-Josée , Mesnage Valérie , Heilbrunn Charlotte , Pateron Dominique , Andro-Melin Alexandra , Fain Olivier , Carbonell Nicolas , Bourrier Anne , Thomas Caroline , Libeaut Delphine , Coichard Christian-Guy , Polomeni Alice , Guidet Bertrand 
Published: March 2022

Background The first COVID-19 wave started in February 2020 in France. The influx of patients requiring emergency care and high-level technicity led healthcare professionals to fear saturation of available care. In that context, the multidisciplinary Ethics- Support Cell (EST) was created to help medical teams consider the decisions that could potentially be sources of ethical dilemmas. Objectives The primary objective was to prospectively collect information on requests for EST assistance from 23 March to 9 May 2020. The secondary aim was to describe the Cell’s functions during that period. Research design This observational, real-time study of requests for Cell consultations concerned ethical dilemmas arising during a public health crisis. The EST created a grid to collect relevant information (clinical, patient’s/designated representative’s preferences and ethical principles strained by the situation), thereby assuring that each EST asked the same questions, in the same order. Participants and research context Only our university hospital’s clinicians could request EST intervention. Ethical considerations The hospital Research Ethics Committee approved this study (no. CER-2020-107). The patient, his/her family, or designated representative was informed of this ethics consultation and most met with EST members, which enabled them to express their preferences and/or opposition. Findings/results 33 requests (patients’ mean age: 80.8 years; 29 had COVID-19: 24 with dyspnea, 30 with comorbidities). 17 Emergency Department solicitations concerned ICU admission, without reference to resource constraints; others addressed therapeutic proportionality dilemmas. Discussion Intervention-request motives concerned limited resources and treatment intensity. Management revolved around three axes: the treatment option most appropriate for the patient, the feasibility of implementation, and dignified care for the patient. Conclusions COVID-19 crisis forced hospitals to envisage prioritization of ICU access. Established decision-making criteria and protocols do not enable healthcare professionals to escape ethical dilemmas. That acknowledgement highlights ethical risks, enhances the added-value of nursing and encourages all players to be vigilant to pursue collective deliberations to achieve clear and transparent decisions.
Prevalences of Overweight and Obesity in Children and Adolescents: The Comparison of ADHD and Other Clinical Samples
Authors: Jongpitakrat Kanyarat , Limsuwan Nida 
Published: March 2022

Objective: To investigate the prevalence of overweight and obesity in children and adolescents with ADHD and compare to other clinical samples. Method: A retrospective chart reviewing of 165 ADHD and 305 other clinical participants aged 6 to 18 years. Results: There was no statistically significant difference in terms of the prevalences of overweight and obesity between ADHD and other clinical participants. In ADHD group, the prevalences of overweight, obesity, and combined overweight/obesity were 15.8%, 20.0%, and 35.8%, respectively. In addition, male gender was significantly associated with increasing the prevalences of overweight and obesity in children and adolescents with ADHD. Conclusion: The prevalences of overweight and obesity between ADHD and other clinical samples were not different in a clinical setting. Male gender was significantly associated with increasing the prevalences of overweight and obesity in children and adolescents with ADHD.
Regression of treatment-resistant gyrate atrophy-associated intraretinal cystic spaces using long-term diet restriction: A case report
Authors: Elhusseiny Abdelrahman M. , Haseeb Abid , Elnahry Ayman G. 
Published: March 2022

Purpose Gyrate atrophy of the choroid and retina (GA) is a rare genetic ophthalmologic condition which primarily manifests in childhood. It is characterized by hyperornithinemia and progressive chorioretinal atrophy. Patients may develop macular intraretinal cystic spaces (ICS) for which various treatment modalities have been reported. We report a patient who failed to demonstrate visual or anatomic improvement following multiple treatments for GA-associated ICS but showed improvement following prolonged dietary modification and vitamin supplementation. Case description A 6-year-old male patient presented with previously undiagnosed GA associated with ICS. He received 6 consecutive monthly intravitreal bevacizumab injections as well as topical nepafenac and dorzolamide for treatment of ICS without significant change detected by optical coherence tomography (OCT) following treatment. He was also maintained on an arginine restricted diet with vitamin B6 supplementation. Over the course of the ensuing year, the patient was lost to follow-up due to the coronavirus disease 2019 pandemic. When he returned, his vision was stable, and OCT showed regression of the ICS. His mother reported that he had continued only on dietary restriction and vitamin B6 supplementation with no other medications or interventions. Plasma ornithine level measurement confirmed dietary compliance. Further follow-up showed continued stabilization of the condition. Conclusion In addition to retarding progressive chorioretinal atrophy, prolonged dietary modifications may result in improvement of treatment-resistant GA-associated ICS. Parents’ education on the value of dietary modifications for patients with GA is highly recommended.
Bilateral cytomegalovirus retinitis as the presenting feature of Dyskeratosis Congenita
Authors: Arora Atul , Singh Ramandeep , Dogra Mohit 
Published: March 2022

Purpose To describe a young male with bilateral sequential Cytomegalovirus retinitis (CMVR) as the presenting feature of Dyskeratosis Congenita Case report A 25-year-old human immunodeficiency virus (HIV) negative male developed CMVR in his left eye, while on a three week course of oral valganciclovir therapy for CMV retinitis in his right eye. Systemic examination revealed reticular hypopigmentation of the forearms, dystrophic nails, oral leukoplakia and complete blood counts showed pancytopenia. A diagnosis of Dyskeratosis Congenita was confirmed with genetic testing. Conclusion CMVR in non-HIV individuals should be considered as a harbinger of systemic immunosuppressive conditions. Ophthalmologists may be the first ones to suspect and diagnose congenital immunosuppressive disorders like Dyskeratosis Congenita in these patients.
Stimulation of Erythrocyte Membrane Blebbing by Bifenthrin Induced Oxidative Stress
Authors: Mukhtar Fatima , Jilani Kashif , Bibi Ismat , Mushtaq Zahid , Bari Khan Maham Abdul , Fatima Maria 
Published: March 2022

Background Bifenthrin is an insecticide and anti-estrogenic compound primarily used to control residential pests by depolarizing sodium gated voltage channels in the nervous system. Eryptosis, the suicidal death of erythrocytes, featured by PS exposure, membrane blebbing and cell shrinkage. Anemia is an outcome of uncontrolled eryptosis. Research Design In this study, erythrocytes were treated with different concentrations (.5-1-1.5 μM) of bifenthrin over a period of 48 hours. In order to investigate the oxidative stress induced by bifenthrin, catalase, superoxide dismutase, and glutathione peroxidase activities were investigated. Results Obtained data indicated the decrease in the enzymes (superoxide dismutase, glutathione peroxidase, and catalase) activities in bifenthrin treated cells at 1 μM concentration. In addition, measurement of cell size and confirmation of the role of calcium in the stimulation of the eryptotic activity of bifenthrin were performed. A significant increase in mean cell volume was found in the presence of bifenthrin and a decrease in mean cell volume in the presence of calcium channel blocker was observed. Similarly, there was also a significant increase in the percentage of hemolysis indicating the necrotic activity of bifenthrin. Conclusions It is concluded that the indicated doses of bifenthrin triggered oxidative stress which may lead to early cell death by eryptosis and hemolysis.
Innovative impact testing machine for enhancing impact related research in Australia
Authors: Asad Mohammad , Zahra Tatheer , Thambiratnam David P , Chan Tommy HT , Liu Xuemei , Zhuge Yan , Hayne Mark , Morris Anthony , Nguyen Christina 
Published: March 2022

This paper summarises the development of a state-of-art impact testing machine for simulating impacts such as vehicular crashes or debris impacts onto structures. The machine has a 200 kg pneumatically powered projectile which can travel horizontally within the barrel of the machine with a maximum velocity of 50 m/s to impact the target structure. The maximum kinetic energy that can be generated by the projectile is 125 kJ by using different combinations of mass and velocity. The diameter of the projectile is 214 mm, and its impacting face can be changed to different shapes, such as flat circle, flat square or an elliptical nose to suit different impact scenarios. An innovative braking mechanism incorporating a crush tube is attached within the barrel to ensure safety when the projectile fails to be restrained by the impact. The crush tube can absorb the maximum imparted by the moving projectile. An advanced data acquisition system is installed to collect quantitative and qualitative test data during a period of 50 ms to 1 s. Two high-speed digital image correlation (DIC) cameras are attached and synchronised with the operation of the impact testing machine to record the images at the rate of 50,000 frames per second. Outputs in terms of strains, deformations, accelerations of the target structure with a record of damage history can be analysed using this 3D DIC technique. The paper also briefly presents the first application of this machine for impact testing masonry wall structures.
Review of Postoperative Delirium in Geriatric Patients After Hip Fracture Treatment
Authors: Albanese Anita M. , Ramazani Noyan , Greene Natasha , Bruse Laura 
Published: March 2022

Introduction Postoperative delirium (POD) is a serious complication occurring in 4–53.3% of geriatric patients undergoing surgeries for hip fracture. Incidence of hip fractures is projected to grow 11.9% from 258,000 in 2010 to 289,000 in 2030 based on 1990 to 2010 data. As prevalence of hip fractures is projected to increase, POD is also anticipated to increase. Signficance Postoperative delirium remains the most common complication of emergency hip fracture surgery leading to high morbidity and mortality rates despite significant research conducted regarding this topic. This study reviews literature from 1990 to 2021 regarding POD in geriatric hip fracture management. Results Potentially modifiable and non-modifiable risk factors for developing POD include, but are not limited to, male gender, older age, multiple comorbidities, specific comorbidities (dementia, cognitive impairment, diabetes, vision impairment, and abnormal blood pressure), low BMI, preoperative malnutrition, low albumin, low hematocrit, blunted preoperative cytokines, emergency surgery, time to admission and surgery, preoperative medical treatment, polypharmacy, delirium-inducing medications, fever, anesthesia time, and sedation depth and type. Although the pathophysiology remains unclear, the leading theories suggest neurotransmitter imbalance, inflammation, and electrolyte or metabolic derangements as the underlying cause of POD. POD is associated with increased length of hospital stay, cost, morbidity, and mortality. Prevention and early recognition are key factors in managing POD. Methods to reduce POD include utilizing interdisciplinary teams, educational programs for healthcare professionals, reducing narcotic use, avoiding delirium-inducing medications, and multimodal pain control. Conclusion While POD is a known complication after hip fracture surgery, further exploration in prevention is needed. Early identification of risk factors is imperative to prevent POD in geriatric patients. Early prevention will enhance delivery of health care both pre- and post-operatively leading to the best possible surgical outcome and better quality of life after hip fracture treatment.
Task-driven knowledge graph filtering improves prioritizing drugs for repurposing
Authors: Ratajczak Florin , Joblin Mitchell , Ringsquandl Martin , Hildebrandt Marcel 
Published: March 2022

AbstractBackgroundDrug repurposing aims at finding new targets for already developed drugs. It becomes more relevant as the cost of discovering new drugs steadily increases. To find new potential targets for a drug, an abundance of methods and existing biomedical knowledge from different domains can be leveraged. Recently, knowledge graphs have emerged in the biomedical domain that integrate information about genes, drugs, diseases and other biological domains. Knowledge graphs can be used to predict new connections between compounds and diseases, leveraging the interconnected biomedical data around them. While real world use cases such as drug repurposing are only interested in one specific relation type, widely used knowledge graph embedding models simultaneously optimize over all relation types in the graph. This can lead the models to underfit the data that is most relevant for the desired relation type. For example, if we want to learn embeddings to predict links between compounds and diseases but almost the entirety of relations in the graph is incident to other pairs of entity types, then the resulting embeddings are likely not optimised to predict links between compounds and diseases. We propose a method that leverages domain knowledge in the form of metapaths and use them to filter two biomedical knowledge graphs (Hetionet and DRKG) for the purpose of improving performance on the prediction task of drug repurposing while simultaneously increasing computational efficiency.ResultsWe find that our method reduces the number of entities by 60% on Hetionet and 26% on DRKG, while leading to an improvement in prediction performance of up to 40.8% on Hetionet and 14.2% on DRKG, with an average improvement of 20.6% on Hetionet and 8.9% on DRKG. Additionally, prioritization of antiviral compounds for SARS CoV-2 improves after task-driven filtering is applied.ConclusionKnowledge graphs contain facts that are counter productive for specific tasks, in our case drug repurposing. We also demonstrate that these facts can be removed, resulting in an improved performance in that task and a more efficient learning process.
Geographical inequalities in the decreasing 28-day mortality following incident acute myocardial infarction: a Danish register-based cohort study, 1987–2016
Authors: Fuglsang Niels Asp , Zinck Elisabeth , Ersbøll Annette Kjær , Ersbøll Bjarne Kjær , Gislason Gunnar Hilmar , Kjærulff Thora Majlund , Bihrmann Kristine 
Published: March 2022

AbstractBackgroundMortality following acute myocardial infarction (AMI) has decreased in western countries for decades; however, it remains unknown whether the decrease is distributed equally across the population independently of residential location. This study investigated whether the observed decreasing 28-day mortality following an incident AMI in Denmark from 1987 to 2016 varied geographically at municipality level after accounting for sociodemographic characteristics.MethodsA register-based cohort study design was used to investigate 28-day mortality among individuals with an incident AMI. Global spatial autocorrelation (within sub-periods) was analysed at municipality level using Moran's I. Analysis of spatio-temporal autocorrelation before and after adjusting for sociodemographic characteristics was performed using logistic regression and conditional autoregressive models with inference in a Bayesian setting.ResultsIn total, 368,839 individuals with incident AMI were registered between 1987 and 2016 in Denmark; 128,957 incident AMIs were fatal. The 28-day mortality decreased over time at national level with an odds ratio of 0.788 (95% credible interval (0.784, 0.792)) per 5-year period after adjusting for sociodemographic characteristics. The decrease in the 28-day mortality was geographically unequally distributed across the country and in a geographical region in northern Jutland, the 28-day mortality decreased significantly slower (4–12%) than at national level.ConclusionsDuring the period from 1987 to 2016, the 28-day mortality following an incident AMI decreased substantially in Denmark. However, in a local geographical region, the 28-day mortality decreased significantly slower than in the rest of the country both before and after adjusting for sociodemographic differences. Efforts should be made to keep geographical trend inequalities in the 28-day mortality to a minimum.
Isolated IgG4-related cholecystitis with localized gallbladder wall thickening mimicking gallbladder cancer: a case report and literature review
Authors: Harada Yuko , Mihara Kisyo , Amemiya Ryusuke , Nakagawa Masashi , Hanada Ryota , Inoue Kentaro , Shito Masaya , Orikasa Hideki , Aiura Koichi 
Published: March 2022

Abstract
Background
IgG4-related cholecystitis, which is a manifestation of IgG4-related disease in the gallbladder, is associated with autoimmune pancreatitis or IgG4-related sclerosing cholangitis in most cases; isolated gallbladder lesions without systemic manifestations are very rare. Gallbladder wall thickening is often diffuse, but sometimes localized, in which case, differentiation from gallbladder cancer becomes difficult. The characteristic features of IgG4-related cholecystitis on imaging that would enable differentiation from gallbladder cancer remain poorly described.

Case presentation
We present a rare case of isolated IgG4-related cholecystitis with localized gallbladder wall thickening that was clinically difficult to distinguish from malignancy before resection. An 82-year-old man was referred to our hospital because of gallbladder wall thickening on abdominal ultrasonography without any symptoms. Dynamic computed tomography of the abdomen showed localized wall thickening from the body to the fundus of the gallbladder that was enhanced from an early stage with a prolonged contrast effect. There were no other findings, such as pancreatic enlargement and bile duct dilatation. Magnetic resonance cholangiopancreatography revealed neither dilatation nor stenosis of the bile duct and pancreatic duct. Endoscopic ultrasonography (EUS) showed a smooth layered thickening of the gallbladder wall with a maximum thickness of 6 mm and a well-preserved outermost hyperechoic layer in the same area. Laparoscopic cholecystectomy was performed because malignancy could not be completely ruled out. Pathological examination of a resected specimen revealed IgG4-positive plasma cell infiltration, fibrosis, and phlebitis. Although the serum IgG4 level measured after resection was normal, the condition was ultimately diagnosed as probable IgG4-related cholecystitis according to the 2020 revised comprehensive diagnostic criteria for IgG4-related disease. The EUS images reflected the pathological findings, in which lymphocytic infiltration was distributed in a laminar fashion in the gallbladder wall.

Conclusions
Although rare, isolated IgG4-related cholecystitis with localized wall thickening mimicking gallbladder cancer remains a clinical problem. A smooth laminar thickening of the gallbladder wall on EUS imaging could be one of the most informative characteristics for differentiating IgG4-related cholecystitis from gallbladder cancer.