bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paracetamol preceding very preterm birth: Is it safe?
Authors: Laitala Aliisa , Saarela Timo , Vääräsmäki Marja , Hallman Mikko , Aikio Outi 
Published: June 2022

AbstractIntroductionThe use of paracetamol for pain relief in pregnancy is common. However, the influence of paracetamol on the perinatal adaptation of high‐risk infants has not been studied. These data are important for safety, since another inhibitor of prostaglandin synthesis is harmful to infants born very preterm and increases serious morbidity. We studied whether the use of paracetamol had an adverse influence on neonatal adaptation and the outcomes of infants during the first hospitalization.Material and MethodsWe studied the patient records of high‐risk mothers and their infants born before 32 weeks of gestation for multiple variables over a period of 84 months in Oulu University Hospital, a regional tertiary care hospital caring for high‐risk deliveries and providing neonatal intensive care. In a matched cohort setting, the exposition was defined as paracetamol use <24 h before childbirth. The controls had consumed no paracetamol up to 1 week before delivery. Infants with major anomalies were excluded. The primary outcome was defined as the need for early interventional treatments for the preterm infants. Outcomes during the first hospitalization were also studied.ResultsAltogether, 170 fetuses from 149 mothers were exposed to paracetamol during the study period. The control population, delivering during the same period, consisted of 118 non‐exposed fetuses from 104 mothers. Among them, the mothers were pairwise matched according to their medications, amniotic fluid leakage time, clinical infections, and delivery mode. After matching, 72 mothers/group remained, resulting in 88 paracetamol‐exposed infants and 85 controls. No perinatal adverse reactions were detected. There were no differences in either circulatory support during the first postnatal day or in the risk for major diseases during the first hospitalization. Paracetamol‐exposed infants needed fewer acute delivery room therapies (51.1% vs 65.9%, mean difference −14.89; 95% confidence interval −0.29 to −0.003). Maternal total paracetamol dose in the 1 week before delivery correlated positively with Apgar scores.ConclusionsAntenatal paracetamol given within 24 h before birth had no adverse effects on extremely or very preterm infants. The long‐term safety of paracetamol and the potential acute benefits for preterm infants during perinatal transition remain to be proven in larger, prospective settings.
Nicardipine for treating severe antepartum hypertension during pregnancy: Nine years of experience in more than 800 women
Authors: Nij Bijvank Sebastiaan W. , Hengst Micky , Cornette Jerome C. , Huigen Sigrid , Winkelen Anne van , Edens Mireille A. , Duvekot Johannes J. 
Published: June 2022

AbstractIntroductionWomen with severe hypertension during pregnancy require prompt stabilization with a combination of magnesium sulfate and rapidly acting intravenously administered antihypertensives. It remains unknown which antihypertensive is best suited for pregnancy. The present study evaluated the intravenous use of the calcium antagonist, nicardipine.Material and MethodsThis multicenter, retrospective case series included all pregnant women beyond 20 weeks of gestation with severe antepartum hypertension that were treated with intravenous nicardipine. Primary outcome measures: successful treatment, time to successful treatment, and maternal safety. Severe hypertension was defined as systolic blood pressure (SBP) of 160 mm Hg or more and/or diastolic blood pressure (DBP) of 110 mm Hg or more.ResultsThis study included 830 women. After 1 h of treatment, two‐thirds of the women had SBP below 160 mm Hg and DBP below 100 mm Hg. In three out of four women, the mean arterial pressure was below 120 mm Hg. Within 2 h of treatment, 77.4% of women achieved successful treatment. In all cases, nicardipine was eventually effective. Within the first 2 h, 42.7% of women experienced temporary low DBP (ie below 70 mm Hg) without clinical consequences for the mother or fetus. In all cases, the low DBP resolved after discontinuing or reducing the dosage of nicardipine. One case of fetal distress was attributable to maternal hypotension, and a cesarean section was performed at more than 2 h after initiating therapy. During treatment, headache, nausea, and vomiting decreased significantly.ConclusionsTo date, this was the largest case‐series study on the use of nicardipine for treating severe antepartum hypertension in pregnancy. We found that nicardipine could effectively and safely treat this condition. Based on its high success rate and acceptable safety profile, nicardipine should be considered a first‐line treatment in women with severe hypertension in pregnancy.
Possible links between phenotypic variability, habitats and connectivity in the killifish Aphaniops stoliczkanus in Northeast Oman
Authors: Bidaye Riya G. , Al‐Jufaili Saud M. , Charmpila Eleni A. , Jawad Laith , Vukić Jasna , Reichenbacher Bettina 
Published: June 2022

AbstractThere is a significant gap in our knowledge of the intraspecific morphological variability in freshwater fish, although such data are crucial for understanding species diversity. Here we use the killifish Aphaniops stoliczkanus (Day, 1872; Aphaniidae: Cyprinodontiformes), which is a widespread but poorly known freshwater species in the Middle East, to investigate variability in morphological traits within and between its populations. As otolith morphology is known to evolve on ecological timescales and can signal the presence of cryptic lineages, a special focus lies on otolith variability. Based on samples from six populations in northern Oman, we found that variation in pigmentation, disparities in body shape and otolith variability can be associated with distinctive environmental conditions. The unique otolith shape of A. stoliczkanus from a hot sulphuric spring (Nakhal) suggests that a cryptic lineage may have emerged there. Our new data can serve as a benchmark for future studies on the diversity of Aphaniops and other Aphaniidae and help to clarify whether cryptic diversity is present in some lineages. Moreover, our data can serve as an actualistic model for studies on fossil fishes, in which morphological characters provide the only accessible data source for taxonomic and phylogenetic interpretations.
Prevalence, associated factors and level of dependence of substance use among urban secondary school students, Benin
Authors: Bio‐sya Assad , Damien Georgia Barikissou , Kpatchavi Adolphe C. , Allabi Aurel C. 
Published: June 2022

AbstractThe use of psychoactive substances is constantly increasing, particularly among young people. This study aimed to estimate the prevalence, associated factors and the level of dependence of those substances among secondary school students in Benin. This cross‐sectional study included 627 students in grades 8–12, selected using a multi‐stage sampling technique. Data were collected using the ASSIST questionnaire, followed by urine screening. Logistic regression analysis was performed to estimate factors associated with substance use. Overall, the lifetime prevalence of psychoactive substance use was 95.4% (95% CI = 93.4–96.9), while the current use was 78.8% (95% CI = 75.3–81.9). The most commonly used substances in the past 3 months were alcohol, followed by stimulants and tobacco; 221 samples were analysed. Twenty‐two (9.95%) were positive by urine screening. Substances detected were tramadol, fentanyl, THC, K2, BZDs, alcohol, methamphetamine and cotinine. Of the current users, 2.27% (n = 11) were at high risk of dependency. An association was found between substance use and age (p = 0.02). In conclusion, this study came up with a high prevalence of substance use among students. There is a need to develop and implement a health education programme in secondary schools to raise awareness of the potential risks.
The prognosis of endometrial cancers stratified with conventional risk factors and modified molecular classification
Authors: Yamazaki Hiroyuki , Asano Hiroshi , Hatanaka Kanako C. , Matsuoka Ryosuke , Konno Yosuke , Matsuno Yoshihiro , Hatanaka Yutaka , Watari Hidemichi 
Published: June 2022

AbstractThis study aimed to validate the Proactive Molecular Risk Classifier for Endometrial Cancer, a modified version of The Cancer Genome Atlas, using data from 184 patients with endometrial cancer (median age: 57.5 years; median follow‐up period: 109 months) who had undergone radical surgery (including systemic lymphadenectomy) and subsequent adjuvant chemotherapy (patients with intermediate or high recurrence risk) from 2003 to 2015. Tissue microarrays were prepared from surgical specimens and classified using the conventional clinical risk classifier. Immunohistochemistry was used to detect mismatch repair proteins, L1 cell adhesion molecule, and p53. Direct sequencing was used to identify hotspot mutations in the polymerase‐epsilon gene. Forty‐five patients were identified as having high L1 cell adhesion molecule expression, 41 as low risk, 34 as mismatch repair‐deficient, 13 as polymerase‐epsilon gene‐mutated, five as having abnormal p53, and 46 as other. Patients were stratified into significantly different prognostic groups (p < 0.0001): favorable (low risk and polymerase‐epsilon gene‐mutated), intermediate (mismatch repair‐deficient and other), and unfavorable (high L1 cell adhesion molecule expression and abnormal p53) with 5‐year disease‐specific survival rates of 100%, 93.8%, and 75.1%, respectively (Kaplan–Meier method). The combination of conventional recurrent risk classification, sequencing for polymerase‐epsilon gene mutations and immunohistochemistry for L1 cell adhesion molecule, p53, and mismatch repair proteins can be used to determine the prognoses of patients with endometrial cancer.
A newly growing asymptomatic facial lesion
Authors: Butt Sanaa , Evans Alan , Green Cathy , Affleck Andrew 
Published: June 2022

AbstractA 23-year-old man presenting with a 1-year history of a lesion of the right cheek. We highlight this case for awareness as this tumour may mimic other benign lesions, such as pilomatrixoma or benign cysts, as it does not have any uniquely identifying clinical or dermoscopic features. Additionally, it is of concern as malignant transformation can occur and therefore surgery should be considered as both for diagnostic and therapeutic benefit.
The role of bacterial corrosion on recolonization of titanium implant surfaces: An in vitro study
Authors: Weller Julia , Vasudevan Praveen , Kreikemeyer Bernd , Ekat Katharina , Jackszis Mario , Springer Armin , Chatzivasileiou Kyriaki , Lang Hermann 
Published: June 2022

AbstractBackgroundInflammation triggered by bacterial biofilms in the surrounding tissue is a major etiological factor for peri‐implantitis and subsequent implant failure. However, little is known about the direct effects of bacterial corrosion and recolonization on implant failurePurposeTo investigate the influence of oral commensals on bacterial corrosion and recolonization of titanium surfaces.Materials and MethodsStreptococcus sanguinis (S. sanguinis) and Porphyromonas gingivalis (P. gingivalis), which are key bacteria in oral biofilm formation, were cultured on commercially pure titanium and titanium‐aluminum‐vanadium (Ti6Al4V) plates in artificial saliva/brain heart infusion medium under aerobic or anaerobic conditions. Biofilm formation was examined after 7 and 21 days by crystal violet and live/dead staining. Titanium ions released into culture supernatants were analyzed over a period of 21 days by atomic absorption spectrometry. Visual changes in surface morphology were investigated using scanning electron microscopy. Biofilm formation on sterilized, biocorroded, and recolonized implant surfaces was determined by crystal violet staining.ResultsS. sanguinis and P. gingivalis formed stable biofilms on the titanium samples. Bacterial corrosion led to a significant increase in titanium ion release from these titanium plates (p < 0.01), which was significantly higher under aerobic conditions on pure titanium (p ≤ 0.001). No obvious morphological surface changes, such as pitting and discoloration, were detected in the titanium samples. During early biofilm formation, the addition of titanium ions significantly decreased the number of live cells. In contrast, a significant effect on biofilm mass was only detected with P. gingivalis. Bacterial corrosion had no influence on bacterial recolonization following sterilization of titanium and Ti6Al4V surfaces.ConclusionBacterial corrosion differs between oral commensal bacteria and leads to increased titanium ion release from titanium plates. The titanium ion release did not influence biofilm formation or bacterial recolonization under in vitro conditions
Does utilization of heart machine perfusion for donation after cardiac death transplantation affect outcomes of other abdominal transplanted organs?
Authors: Okumura Kenji , Misawa Ryosuke , Ohira Suguru , Dhand Abhay , Kai Masashi , Sogawa Hiroshi , Veillette Gregory , John Devon , Diflo Thomas , Nishida Seigo 
Published: June 2022

AbstractIntroductionMachine perfusion of heart for donation after circulatory death (DCD) is being increasingly utilized. Current protocols for utilizing heart DCD's machine perfusion might prolong donor warm ischemic time for nonheart organs. The aim of this study was to analyze the effects of utilizing heart machine perfusion on liver and kidney transplants from the same donor.MethodsWe analyzed data of DCD donors from the United Network for Organ Sharing (UNOS) from January‐2020 to September‐2021 among two groups: donors with heart machine perfusion (HM) and without heart machine perfusion (NHM). Propensity score (PS) matching was performed to compare the short‐term outcomes of liver and kidney transplants between two groups.ResultsTotal of 102 liver and 319 kidney transplants were performed using organs from donors with HM. After PS matching, no statistically significant difference was seen in 1‐year graft survival (GS) for both liver and kidney transplants between two groups (liver HM 90.6% vs. NHM 90.2%, p = .47; kidney HM 95.2% vs. NHM 92.9%, p = .40). There was no difference in the delayed graft function (DGF) rates in kidney transplantation (KT) (HM 42% vs. NHM 35%, p = .062).ConclusionUtilization of heart machine perfusion in DCD donors had no significant impact on 1‐year outcomes of liver and kidney transplantation.
A rare case of cutaneous interdigitating dendritic cell sarcoma
Authors: Doan Leandra , Sanyal Riana D. , Cassarino David S. 
Published: June 2022

AbstractInterdigitating dendritic cell sarcomas (IDCSs) are aggressive tumors of dendritic cells, often presenting with lymphadenopathy. Fewer than 10 cases of primary cutaneous IDCS have been reported. Histopathologically, IDCS presents as atypical spindle cells with irregular nuclei, and therefore can be difficult to distinguish from melanoma, follicular dendritic cell sarcoma, and Langerhans cell tumors by H&E examination alone. We report a unique case of a man with cutaneous IDCS that was initially misdiagnosed as melanoma. Having previously undergone an excision of a reported “melanoma” on the neck, he presented with a new growth on the cheek. Histopathologic findings revealed an atypical dermal lymphohistiocytic infiltrate around vessels and cells forming nests along the dermal‐epidermal junction. Immunohistochemical stains were strongly positive for S100, fascin, and lysozyme; on the other hand, CD1a, langerin, CD21, CD23, and SOX10 were negative. These immunohistochemical findings were consistent with IDCS, and the patient's prior biopsy specimen was then revisited. Similar staining revealed that lesion also to be a cutaneous IDCS. Follow‐up imaging with PET scan was negative for metastases, supporting the diagnosis of primary cutaneous IDCS. Our findings contribute to the limited literature on cutaneous IDCS and highlight a potential pitfall in its diagnosis because of overlapping histopathologic features with melanoma.
Decision biases in revenue management revisited: Dynamic decision‐making under stationary and nonstationary demand
Authors: Cleophas Catherine , Schüetze Claudia 
Published: June 2022

AbstractState‐of‐the‐art revenue management systems combine forecasting and optimization algorithms with human decision‐making. However, only a few existing contributions consider the behavioral aspects of revenue management. To extend the related research, we examine the impact of nonstationary demand and two dynamic decision tasks. We examine human decision‐making strategies and biases by implementing a related experimental design in a laboratory study and comparing participant decisions to systematic heuristics. Our results highlight that participants struggle to accommodate a nonstationary willingness to pay. In that, they exhibit a combination of optimism and loss aversion biases. We further find that participants anchor their decisions on customers' willingness to pay. We draw implications and further research opportunities to behaviorally inform the design of symbiotic analytics systems from these results.
Behavioral disruption of two orchard hemipteran pests by garlic essential oil
Authors: Denoirjean Thomas , Rivière Mélanie , Doury Géraldine , Le Goff Guillaume Jean , Ameline Arnaud 
Published: June 2022

AbstractEssential oils (EOs) are promising sources of effective bioactive compounds for insect pest control, especially in heavily treated agrosystems like orchards. Plants belonging to the Amaryllidaceae family – onion, garlic (Allium sativum L.), and others – present an interesting potential in apple (Malus domestica Borkh.) and pear (Pyrus communis L., both Rosaceae) tree integrated pest management due to the repellent and deterrent properties of their chemical compounds. This study explores the potential disruption by garlic EOs of the behavior of two hemipteran pests towards their host trees: rosy apple aphid, Dysaphis plantaginea (Passerini) (Aphididae), on cultivated apple, and pear psyllid, Cacopsylla pyri (L.) (Psyllidae), on pear. Effects on orientation and feeding behavior were evaluated using choice tests and the electropenetrography (EPG) technique. The results revealed that garlic EOs delivered through rubber dispensers were intrinsically repellent, but when combined with the attractive host plant, the repellents and attractants canceled each other out for the two studied hemipterans. Garlic EOs caused disruptions in the feeding behavior of the two insects, particularly the psyllids, which showed a decrease in phloem sap intake. This study highlights the mechanisms disrupting the process of host‐plant colonization, in particular the possible masking of host‐locating cues or the involvement of confusing chemical stimuli due to EO volatiles.
Views of young people with psychosis on using virtual reality assisted therapy. A qualitative study
Authors: Holgersen Guri , Nordgreen Tine , ten Velden Hegelstad Wenche , Bircow Elgen Irene 
Published: June 2022

AbstractAimService disengagement is a challenge in young individuals struggling with psychosis. Combining cognitive behavioural therapy for psychosis (CBTp) with virtual reality (VR) has proven acceptable and potentially effective for symptoms and social functioning in adults with psychosis. However, studies focusing on young adolescents are lacking. The aim of the present study was to investigate the acceptability of VR‐assisted CBTp among adolescents with psychosis.MethodsA qualitative study investigating the acceptability of VR during exposure‐based social training among adolescents with early onset psychosis. Thematic analysis was used to identify, analyse, interpret and report patterns from the qualitative interviews.ResultsA total of 27 adolescents with psychosis were invited to participate, 11 declined and 16 were enrolled (59%), and all completed the study. The participants were from 13 until 18 years old, mean age 16 years. None of them had previous experience with use of VR in therapy, but 10 out of 16 participants had prior experience with VR from playing video games. Regarding acceptability, 14 out of 16 had positive expectations towards using VR in CBTp, and they would prefer using VR during exposure‐based social training to real‐life training only.ConclusionsVR‐assisted CBTp can be an acceptable intervention for adolescents with psychosis, given their comfort with technology and the opportunity to confront their fears in less threatening virtual social settings with fewer social risks. The present study yields support to continue developing VR‐assisted therapy for adolescents, and focusing on VR‐interventions for early onset psychosis.
Spectral variable selection for estimation of soil organic carbon content using mid‐infrared spectroscopy
Authors: Wang Junwei , Liu Tongqing , Zhang Jixiong , Yuan Huimin , Acquah Gifty E. 
Published: June 2022

AbstractThe non‐destructive and rapid estimation of soil total carbon (SOC) content with mid‐infrared spectroscopy (MIR, 4000–400 cm−1) will play a vital role in precision agriculture. However, the benefit derived from the full MIR range is compromised by multicollinearity and noise. Hence, variable selection methods have been developed to reduce the full spectrum to a few variables that contribute the most information to a property of interest. However, only a few studies have applied variable selection methods in the MIR region to estimate organic carbon content in the soil. Therefore, four variable selection methods, namely stability competitive adaptive reweighted sampling (sCARS), bootstrapping soft shrinkage (BOSS), interval combination optimization (ICO) and the interval combination optimization‐successive projections algorithm (ICO‐SPA) method were investigated to ascertain the method that identified the wavebands most sensitive to SOC in order to improve prediction accuracy. The selected variables (i.e., reduced spectrum), as well as the full MIR spectrum, were coupled with partial least squares regression (PLSR) for the model calibration of SOC. The results showed that the models based on variable selection achieved higher prediction accuracy than the full spectrum model. sCARS selected 19 variables, BOSS selected 21 variables, ICO selected 311 variables, whereas ICO‐SPA selected only 9 variables (accounting for 0.38% of all variables), while the prediction accuracy of the ICO‐SPA‐PLSR model was similar to those of the other three variable selection methods. The ICO‐SPA‐PLSR model had an Rp2 value of 0.93, RPD of 3.90 and RMSEP of 0.13%. This method identified 3450, 2920, 2767, 2000, 1800, 1765, 1600, 1560 and 927 cm−1 as the feature wavenumbers with the most useful information in accurately estimating SOC content. Therefore, the combination strategy of interval (ICO) and individual (SPA) variable selection may be a good alternative variables selection method for MIR spectroscopic data.Highlights
Different spectral variable selection methods were compared for SOC estimation by MIR.
ICO‐SPA variable selection was employed to improve the prediction accuracy of SOC by MIR spectra.
ICO‐SPA method selected informative key spectral variables of SOC in MIR range.
Interval coupled with individual variable selection can be an alternative for spectroscopic data.