bluuebunny/crossref_metadata_2025_split huggingface dataset:
DNA polymerase delta interacting protein 3 facilitates the activation and maintenance of DNA damage checkpoint in response to replication stress
Authors: Zhang Sufang , Lee Ernest Y. C. , Lee Marietta Y. W. T. , Zhang Dong 
Published: September 2022

AbstractBackgroundReplication stress response is crucial for the maintenance of a stable genome. POLDIP3 (DNA polymerase delta interacting protein 3) was initially identified as one of the DNA polymerase δ (Pol δ) interacting proteins almost 20 years ago. Using a variety of in vitro biochemical assays, we previously established that POLDIP3 is a key regulator of the enzymatic activity of Pol δ. However, the in vivo function of POLDIP3 in DNA replication and DNA damage response has been elusive.MethodsWe first generated POLDIP3 knockout (KO) cells using the CRISPR/Cas9 technology. We then investigated its biological functions in vivo using a variety of biochemical and cell biology assays.ResultsWe showed that although the POLDIP3‐KO cells manifest no pronounced defect in global DNA synthesis under nonstress conditions, they are sensitive to a variety of replication fork blockers. Intriguingly, we found that POLDIP3 plays a crucial role in the activation and maintenance of the DNA damage checkpoint in response to exogenous as well as endogenous replication stress.ConclusionOur results indicate that when the DNA replication fork is blocked, POLDIP3 can be recruited to the stalled replication fork and functions to bridge the early DNA damage checkpoint response and the later replication fork repair/restart.
Metal‐Organic Framework@Metal Oxide Heterostructures Induced by Electron‐Beam Radiation
Authors: Chen Junchang , Zhang Mingxing , Zhang Shitong , Cao Kecheng , Mao Xuanzhi , Zhang Maojiang , He Linwei , Dong Xiao , Shu Jie , Dong Hongchun , Zhai Fuwan , Shen Rongfang , Yuan Mengjia , Zhao Xiaofang , Wu Guozhong , Chai Zhifang , Wang Shuao 
Published: September 2022

AbstractMetal organic frameworks (MOFs) are a distinct family of crystalline porous materials finding extensive applications. Their synthesis often requires elevated temperature and relatively long reaction time. We report here the first case of MOF synthesis activated by high‐energy (1.5 MeV) electron beam radiation from a commercially available electron‐accelerator. Using ZIF‐8 as a representative for demonstration, this type of synthesis can be accomplished under ambient conditions within minutes, leading to energy consumption about two orders of magnitude lower than that of the solvothermal condition. Interestingly, by controlling the absorbed dose in the synthesis, the electron beam not only activates the formation reaction of ZIF‐8, but also partially etches the material during the synthesis affording a hierarchical pore architecture and highly crystalline ZnO nanoparticles on the surface of ZIF‐8. This gives rise to a new strategy to obtain MOF@metal oxide heterostructures, finding utilities in photocatalytic degradation of organic dyes.
A Highly Twisted Carbazole‐Fused DABNA Derivative as an Orange‐Red TADF Emitter for OLEDs with Nearly 40 % EQE
Authors: Cheng Ying‐Chun , Fan Xiao‐Chun , Huang Feng , Xiong Xin , Yu Jia , Wang Kai , Lee Chun‐Sing , Zhang Xiao‐Hong 
Published: September 2022

AbstractMultiple resonance (MR) type thermally activated delayed fluorescence (TADF) material is currently a research hotspot in organic light‐emitting diodes (OLEDs) due to their high color purity and high exciton utilization. However, there are only a handful of MR‐TADF emitters with emissions beyond the blue‐to‐green region. The very limited emission colors for MR‐TADF emitters are mainly caused by the fact that so far molecular modifications of MR‐TADF do not offer much change in the emission colors. Here, we report a new approach to modifying a prototypical MR core of DABNA by fusing carbazoles to the MR framework. The carbazole‐fused molecule (TCZ‐F‐DABNA) basically maintains the MR‐dominated features of DABNA while red‐shifting the emission. Its OLED achieves an external quantum efficiency of 39.2 % with a peak at 588 nm, which is a record‐high efficiency for OLEDs with peaks beyond 560 nm. This work provides a new approach for significantly tunning emission colors of MR‐TADF emitters.
Amorphous Calcium Carbonate Cluster Nanospheres in Water‐Deficient Organic Solvents
Authors: Ju Yi‐Ming , Zhao Yang , Guan Qing‐Fang , Yang Si‐Yao , Wang Wei , Yan Bei‐Bei , Meng Yu‐Feng , Li Si‐Cheng , Tang Pei‐Ping , Mao Li‐Bo , Yu Shu‐Hong 
Published: September 2022

AbstractAs the key intermediate phase of crystalline calcium carbonate biominerals, amorphous calcium carbonate (ACC) remains mysterious in its structures because of its long‐range disorder and instability. We herein report the synthesis of ACC nanospheres in a water‐deficient organic solvent system. The obtained ACC nanospheres are very stable under dry conditions. Cryo‐TEM reveals that each nanospheres consists of smaller nanosized clusters. We further demonstrate that these clusters can precipitate on other substrates to form an ultrathin ACC coating, which should be an ACC cluster monolayer. The results demonstrate that the presence of small ACC clusters as the subunits of larger aggregates is inherent to ACC synthesized in water‐alcohol system but not induced by polymer additives.
The association of nausea and vomiting of pregnancy, its treatments, and select birth defects: Findings from the National Birth Defect Prevention Study
Authors: Schrager Nina L. , Parker Samantha E. , Werler Martha M. ,   for the National Birth Defects Prevention Study
Published: September 2022

AbstractBackgroundNausea and vomiting of pregnancy (NVP) occurs in approximately 70% of pregnant people. Treatments include pharmacologic and herbal/natural products. Research on the associations between NVP and its treatments and birth defects is limited.MethodsWe used data from the case–control National Birth Defects Prevention Study (1997–2011) to examine whether first‐trimester NVP or its specific treatments were associated with 37 major birth defects. Odds ratios (aOR) and 95% confidence intervals (CIs) were adjusted for sociodemographic and reproductive factors.ResultsMothers of 66.6% of 28,628 cases and 69.9% of 11,083 controls reported first‐trimester NVP. Compared to no NVP, mothers with NVP had ≥10% reduction in risk of cardiac and noncardiac defects overall, and of 18 specific defects. Over‐the‐counter antiemetic use, compared to untreated NVP, was associated with ≥10% increase in risk for nine defect groups (heterotaxy, hypoplastic left heart syndrome [HLHS], aortic stenosis, cataracts, anophthalmos/microphthalmos, biliary atresia, transverse limb deficiency, omphalocele, and gastroschisis), whereas use of prescription antiemetics increased risk ≥10% for seven defect groups (tetralogy of Fallot, HLHS, spina bifida, anopthlamos/microphthalmos, cleft palate, craniosynostosis, and diaphragmatic hernia). We observed increased risks for promethazine and tetralogy of Fallot (aOR: 1.49, 95% CI: 1.05–2.10), promethazine and craniosynostosis (1.44, 1.08–1.92), ondansetron and cleft palate (1.66, 1.18–2.31), pyridoxine and heterotaxy (3.91, 1.49–10.27), and pyridoxine and cataracts (2.57, 1.12–5.88).ConclusionsNVP does not increase risks of birth defects. Our findings that some treatments for NVP increase risk of specific birth defects should be investigated further before clinical recommendations are made.
Are Misperceptions of Methods in Infectious Disease Ecology Reflected in Biases of Where Studies are Published?
Authors: Bartlett Lewis J. , Washburn Tyler J. 
Published: September 2022

SummaryIn response to the SARS‐CoV‐2 (Covid‐19) pandemic, multiple calls were made for the better use of various tools developed in many disparate academic disciplines. Included in these calls were claims that techniques used widely across ecological sciences could be better capitalized on, despite a rich and longstanding history of including ecology and evolutionary biology in infectious disease research, epidemiology, and public health. Mismatches between the perception of the role of ecology and evolution in governmental infectious disease response and the reality of its inclusion led to those outside the field of infectious disease ecology publishing potentially misleading science, contributing to a wider problem of misinformation. We investigated the anecdotally discussed role of publishing patterns in driving this misperception. We matched abstracts from a leading ecological conference against associated papers published following that conference, and examined differences in publishing destinations for abstracts from infectious disease sessions to abstracts from elsewhere in the conference. We found that relative to other ecological disciplines, infectious disease ecology studies are 1.5 times less likely to be published in ecology journals than is typical across the wider ecology discipline, but are over three times more likely to be published in broader‐scope biological sciences journals. The role of this bias in publication destinations of disease ecology is likely worth consideration, in part as it relates to wider understanding of the appropriateness of involving ecological methods to sensitive topics like pandemic response policy. We suggest that this is not inherently a problem, but does warrant better awareness from ecologists working both within and without infectious disease biology.
Scalable synthesis of the C14–C23 fragment of Eribulin and Halichondrin B
Authors: Kim U Bin , Samala Srinivas , Kim Namhyeon , Bogonda Ganganna , Lago‐Santomé Hugo , Jeong Youngdo , Kim Jin , Jung Jaehun , Jeon Sung‐Hyun , Lee Seung Jong , Shin Hyunik 
Published: September 2022

AbstractA novel, scalable approach to the C14–C23 fragment of eribulin mesylate is disclosed. Key 2,3‐Wittig rearrangement is strategically effected via [Rh] mediated decomposition of 1,2,3‐triazole intermediate to derive the 2,5‐trans‐tetrahydrofuran motif, enabling multi‐kilogram access to the desired C14–C23 fragment.
An online course on applied biochemistry and molecular biology through case‐based learning
Authors: Plasencia Javier 
Published: September 2022

AbstractAn undergraduate online course on Applied Biochemistry and Molecular Biology was developed through different formats of case study that included lecture, class discussion, small‐groups discussion, and individual work. Cases covering health, biotechnology, agriculture, and other issues were developed or adapted from the literature to reach the desired learning goals. Multiple web resources were employed for information integration that were presented and discussed in the synchronous sessions and assignments. Formative and summative assessment was achieved through multiple‐choice questionnaires, exams, and homework assignments.
Two 3D Rubidium Halide Organic–Inorganic Hybrid Perovskite Ferroelectrics Templated by Quasi‐Spherical Organic Amine 1,4‐Diazabicyclo[3.2.2]nonane
Authors: Wei Jing , Han Keke , You Xiuli , Zhang Mengxia , Wei Zhenhong , Zhang Haina , Cai Hu 
Published: September 2022

AbstractThe emergence of (CH3NH3)PbI3 has brought the development of three‐dimensional (3D) organic‐inorganic hybrid perovskite (OIHP) structures with ABX3 type to a higher level; however, most 3D frameworks are constructed by corner‐sharing of BX6 octahedra. Herein, we substituted the spherical molecule 1,4‐diazabicyclo[2.2.2]octane (2.2.2‐dabco) with 1,4‐diazabicyclo[3.2.2]nonane (1,4‐3.2.2‐dabcn) as a template to react with RbX (X=Br, I) in the corresponding HX acids under the consideration of reducing the molecular symmetry. Two 3D OIHP compounds [1,4‐3.2.2‐H2dabcn]RbI3⋅H2O (1) and [1,4‐3.2.2‐H2dabcn]RbBr3 (2) crystallized in non‐centrosymmetric point group mm2 before the phase transition point were isolated. Among them, the 3D inorganic framework of 1 is constructed by sharing the corner of [RbI6] octahedra, while that of 2 is constructed by sharing the corner and face of [RbBr6] octahedra to acquire large cavities to accommodate the organic amine cation [1,4‐3.2.2‐H2dabcn]2+; this 3D framework type is unprecedented in the OIHPs. As expected, compounds 1 and 2 exhibit reversible phase transition, dielectric and second harmonic generation (SHG) and ferroelectric properties, in which the phase transition temperature of 2 at 374 K is much higher than compound 1 at 280 K.
Nanoarchitectonics of RGO‐Wrapped CNF/GO Aerogels with Controlled Pore Structures by PVA‐Assisted Freeze‐Casting Approach for Efficient Sound and Microwave Absorption**
Authors: Zhang Xiaoxiao , Zheng Qitan , Chen Wenzheng , Chen Zhixin , Chen Yujie , Fan Qunfu , Li Hua , Liu Hezhou , Zhu Shenmin 
Published: September 2022

AbstractAcoustic absorption materials play an important role in eliminating the negative effects of noise. Herein, a polyvinyl alcohol (PVA)‐assisted freeze‐casting was developed for controllably fabricating reduced graphene oxide wrapped carbon nanofiber (RGO@CNF)/graphene oxide composite aerogel. During the freeze‐casting, PVA was used as an icing inhibitor to control the size of ice crystals. While the concentration of PVA increased from 0 to 15 mg ⋅ ml−1, the average pore size of the aerogel was reduced from 154 to 45 μm. Due to the modulation of the pore size and composition, the propagation path and friction loss for sound were optimized, especially at low frequency. For instance, the normalized sound absorption coefficient of RGO@CNF/GO‐10 achieves 0.79 (250–6300 Hz). The sample also exhibits a desirable microwave absorbing property whose maximum reflection loss is −47.3 dB (9.44 GHz, d=3.0 mm). Prospectively, this synthetic strategy can be extended to develop other forms of elastic aerogel with a controlled pore size.
A SelectMDx/magnetic resonance imaging‐based nomogram to diagnose prostate cancer
Authors: Wagaskar Vinayak G. , Levy Micah , Ratnani Parita , Sullimada Sharmila , Gerenia Mae , Schlussel Kacie , Choudhury Samia , Gabriele Marla , Haas Ian , Haines Kenneth , Tewari Ash 
Published: September 2022

AbstractBackground70%–80% of prostate cancer (PCa) biopsies performed in the US annually may be unnecessary. Specific antigen testing (PSA) and tans rectal ultrasound (TRUS) are imprecise predictive methods for risk of PCa. Novel strategies are critical to guide biopsy decision‐making.AimWe assessed the utility and accuracy of combining Select MDx and multiparametric magnetic resonance imaging (mpMRI) scores for predicting risk of PCa.Methods and ResultsOur study was conducted at Mount Sinai hospital at Urology department in New York City from January 2020 to April 2021. Total 129 men performed select MDx test. Indications for prostate biopsy were high‐risk Select MDx score, suspicious DRE, PI‐RADS scores 3/4/5 on mpMRI, or any combination of these. Fifty‐one percentage of 129 patients underwent systemic or combined systemic and MRI/US (ultrasound) fusion biopsy; All men underwent 3 T MRI of Prostate w/wo contrast using standard protocols prior to biopsy. A single surgeon performed prostate biopsies.Gleason score ≥3 + 3 on biopsy is defined as outcome. Descriptive statistics were calculated as cross tables. Binary logistic regression model is used to determine the outcome. The nomogram was based on the coefficients of the logit function. ROCs were plotted and decision curve analysis was performed.Using both high‐risk Select MDx and PI‐RADS scores of 4/5, 87% of biopsies could have been avoided, while detecting 64% of PCa and missing 36%. If biopsies were performed on men with positive Select MDx or PI‐RADS 4/5 results, 16% of biopsies could have been avoided while detecting all PCa. Combining these scores improved specificity and accuracy for the detection of PCa over either used alone. Study limitations include limited sample size, sole institution study, and risk or overfitting for the proposed model which may limit generalizability.ConclusionCombining SelectMDx and mpMRI PI‐PADS scores of 4/5 may be useful for PCa biopsy decision‐making.
Network statistics‐based routing and path orient data encryption scheme for efficient healthcare monitoring with IoT in WSN
Authors: Vijayakumar M. 
Published: September 2022

SummaryWireless communication has been adapted for a variety of difficulties as a result of recent developments in sensor networks. The sensors are meant to communicate with network nodes located at a distance and to adapt to various conditions. In addition, Internet of Things (IoT) devices are becoming a part of WSN and are being tailored to various healthcare systems. Nonetheless, the presence of massive nodes and rogue nodes makes transmitting data packets difficult. The procedure, however, confronts a number of obstacles, including data security, continuous monitoring, and routing issues. A variety of ideas are explored to help with the situation, but they all have flaws. A network statistics‐based routing and path orient data encryption system has been developed to address this problem (NSR‐PDE). The strategy focuses on keeping track on patients and providing strong, decisive support systems. The model is created to access data stored on cloud servers and allows for the monitoring of multiple patients in different locations. The model begins by monitoring the whole bodily states of patients in real time using dedicated equipment. Such monitored characteristics are provided over a variety of channels, with route selection based on the patient's class and the type of information being transmitted. The approach calculates the network constraint secure route measure (NCSRM), which is calculated using route information, node behavior, and physical attributes. Similarly, data transmission is protected by path orient data encryption (PDE), which ensures data security according on the route's type and conditions.
Familial risk of dilated and hypertrophic cardiomyopathy: a national family study in Sweden
Authors: Ricci Fabrizio , Banihashemi Behzad , Pirouzifard Mirnabi , Sundquist Jan , Sundquist Kristina , Sutton Richard , Fedorowski Artur , Zöller Bengt 
Published: September 2022

AbstractAimsThis study aims to determine the familial incidence of dilated (DCM) and hypertrophic cardiomyopathy (HCM) in first‐degree, second‐degree, and third‐degree relatives of affected individuals.Methods and resultsIn this population‐based multigenerational cohort study, full‐siblings, half‐siblings, and cousin pairs born to Swedish parents between 1932 and 2015 were included, and register‐based DCM and HCM diagnoses among relatives were ascertained. Adjusted odds ratios (ORs) for DCM and HCM were calculated for relatives of individuals with DCM and HCM compared with relatives of individuals without DCM and HCM for reference. Total study population included 6 334 979 subjects and consisted of 5 577 449 full‐siblings, 1 321 414 half‐siblings, and 3 952 137 cousins. Overall, 10 272 (0.16%) unique individuals were diagnosed with DCM and 3769 (0.06%) with HCM. Of these, 7716 (75.12%) and 2375 (63.01%) were males, respectively. Familial risk ORs for DCM were 5.35 [95% confidence intervals (CI): 4.85–5.90] for full‐siblings, 2.68 (95% CI:1.86–3.87) for half‐siblings, and 1.72 (95% CI:1.12–2.64) for cousins of affected individuals. The ORs for HCM were 42.44 (95% CI:37.66–47.82) for full‐siblings, 32.70 (95% CI:21.32–50.15) for half‐siblings, and 36.96 (95% CI:29.50–46.31) for cousins of affected individuals. In sex‐stratified analysis, relatives of affected females were found more likely to be affected than were relatives of affected males, with stronger aggregation observed for HCM.ConclusionsFamilial risk of HCM and DCM is high and associated with genetic resemblance, with strongest aggregations observed in relatives of affected females with HCM, whereas this association was distinctly attenuated for DCM. The finding of a Carter effect, more pronounced in HCM, suggests a multifactorial threshold model of inheritance.
State transformations through public, multilevel, and territorial governance in European Union: Towards a metagovernance paradigm
Authors: Dias Ricardo C. , Seixas Paulo C. , Lobner Nadine 
Published: September 2022

AbstractThis article discusses “public,” “multi‐level,” and “territorial” governance, highlighting the reformulation of the state based on a double dynamic, vertical and horizontal, of displacement of state power in the European Union. We propose that public governance opened up to the ambivalence between “multi‐level” and “territorial” governance. This ambivalence is evident in the practical challenges within European governance in the making. According to these challenges, Europeanization raises two priorities: subnational structures that enable the state to get closer to the territory and the people, and beyond borders networks between states, institutions, and people(s). This possibility of effectively involving new actors (at all levels) in the political process of the construction of European regions requires a multi‐spatial metagovernance approach.
Investigation of thermal performance in dual‐fuel units
Authors: Xue Xiaochun , Yu Yonggang 
Published: September 2022

AbstractNumerical studies were carried out to investigate the thermal performance of the muzzle flow with strong shock discontinuities and gas–gas heat transfer mechanism in the base bleed unit (BBU) of an aerodynamic vehicle under the combined effects of muzzle flow and depressurization process. The process was modeled using the Navier–Stokes equations with chemical kinetics and interior ballistic equations. The results show that the muzzle phenomena with large temperature gradients and different wave structures appear after the supersonic vehicle enters into the free‐flight stage. The BBU also experiences a strong depressurization process with the release of high‐temperature propellant gas at 2200 K. However, the igniter combustion gas at a higher temperature of 3050 K in the BBU develops downstream and upstream repeatedly under the combined effects of the base wave and depressurization process, which makes the energy conversion process in the unit more complicated. With the projectile leaving the control of the muzzle flow, the BBU is full of the igniter combustion gas and the energy in the unit is uniformly distributed gradually. The high‐temperature area, at approximately 2750 K, propagates downstream along the axial and radial directions simultaneously until it finally dominates the entire unit. The maximum temperature of the combustion gas acting on the propellant surface is always 2740 K and the maximum heat flux remains approximately 1250 W/cm2 at later periods.