bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulmonary Metastasectomy in Colorectal Cancer (PulMiCC) randomized controlled trial: a systematic review of published responses
Authors: Williams Norman R , Patrick Hannah , Fiorentino Francesca , Allen Alexander , Sharma Manuj , Milošević Mišel , Macbeth Fergus , Treasure Tom 
Published: April 2022

Abstract

OBJECTIVES
The objective of this review was to assess the nature and tone of the published responses to the Pulmonary Metastasectomy in Colorectal Cancer (PulMiCC) randomized controlled trial.

METHODS
Published articles that cited the PulMiCC trial were identified from Clarivate Web of Science (©. Duplicates and self-citations were excluded and relevant text was extracted. Four independent researchers rated the extracts independently using agreed scales for the representativeness of trial data and the textual tone. The ratings were aggregated and summarized. Two PulMiCC authors carried out a thematic analysis of the extracts.

RESULTS
Sixty-four citations were identified and relevant text was extracted and examined. The consensus rating for data inclusion was a median of 0.25 out of 6 (range 0–5.25, interquartile range 0–1.5) and, for textual tone, the median rating was 1.87 out of 6 (range 0–5.75, interquartile range 1–3.5). The majority of citations did not provide adequate representation of the PulMiCC data and the overall textual tone was dismissive. Although some were supportive, many discounted the findings because the trial closed early and was underpowered to show non-inferiority. Two misinterpreted the authors’ conclusions but there was an acceptance that 5-year survival was much higher than widely assumed.

CONCLUSIONS
Published comments reveal a widespread reluctance to consider seriously the results of a carefully conducted randomized trial. This may be because the results challenge accepted practice because of ‘motivated reasoning’, but there is a widespread misunderstanding of the fact that though PulMiCC with 93 patients was underpowered to test non-inferiority, it still provides reliable evidence to undermine the widespread belief in a major survival benefit from metastasectomy.
Rhizobial diversity is associated with inoculation history at a two-continent scale
Authors: Zaw Myint , Rathjen Judith R , Zhou Yi , Ryder Maarten H , Denton Matthew D 
Published: April 2022

Abstract
A total of 120 Mesorhizobium strains collected from the central dry zone of Myanmar were analyzed in a pot experiment to evaluate nodulation and symbiotic effectiveness (SE%) in chickpea plants. Phylogenetic analyses revealed all strains belonged to the genus Mesorhizobium according to 16–23S rDNA IGS and the majority of chickpea nodulating rhizobia in Myanmar soils were most closely related to M. gobiense, M. muleiense, M. silamurunense, M. tamadayense and M. temperatum. Around two-thirds of the Myanmar strains (68%) were most closely related to Indian strain IC-2058 (CA-181), which is also most closely related to M. gobiense. There were no strains that were closely related to the cognate rhizobial species to nodulate chickpea: M. ciceri and M. mediterraneum. Strains with diverse 16S–23S rDNA IGS shared similar nodC and nifH gene sequences with chickpea symbionts. Detailed sequence analysis of nodC and nifH found that the strains in Myanmar were somewhat divergent from the group including M. ciceri and were more closely related to M. muleiense and IC-2058. A cross-continent analysis between strains isolated in Australia compared with Myanmar found that there was little overlap in species, where Australian soils were dominated with M. ciceri, M. temperatum and M. huakuii. The only co-occurring species found in both Myanmar and Australia were M. tamadayense and M. silumurunense. Continued inoculation with CC1192 may have reduced diversity of chickpea strains in Australian soils. Isolated strains in Australian and Myanmar had similar adaptive traits, which in some cases were also phylogenetically related. The genetic discrepancy between chickpea nodulating strains in Australia and Myanmar is not only due to inoculation history but to adaptation to soil conditions and crop management over a long period, and there has been virtually no loss of symbiotic efficiency over this time in strains isolated from soils in Myanmar.
Your Item Name is My Trademark: The German Understanding of Use as a Mark in the Context of EU Trademark Law
Authors: Wagner Kristina 
Published: April 2022

Abstract
The most essential trademark function is the origin function, which should enable a person to distinguish the goods and services of one undertaking from those of another. For undertakings there is a likewise evident need to make their own product range distinguishable and identifiable. For this purpose, item names are quite common and certainly catchier than item numbers, since long and random sequences of numbers tend to be difficult to remember. However, conflicts may arise where the item name corresponds with a trademark. In Germany, the Federal Supreme Court issued in 2019 two decisions on item names, SAM (case No. I ZR 195/17) and Damen Hose MO (case No. I ZR 108/18), where it was clarified that the assumption of trademark use is not self-evident. This article discusses whether and how this recent German case law still fits in with EU trademark law and which conclusions can be drawn for item names on an EU-wide scale.
An animal model for Pierpont syndrome: a mouse bearing the Tbl1xr1
Y446C/Y446C mutation
Authors: Hu Yalan , Lauffer Peter , Stewart Michelle , Codner Gemma , Mayerl Steffen , Heuer Heike , Ng Lily , Forrest Douglas , van Trotsenburg Paul , Jongejan Aldo , Fliers Eric , Hennekam Raoul , Boelen Anita 
Published: April 2022

Abstract
Pierpont syndrome is a rare disorder characterized mainly by global developmental delay, unusual facial features, altered fat distribution in the limbs and hearing loss. A specific mutation (p.Tyr446Cys) in TBL1XR1, encoding a WD40 repeat-containing protein, which is a component of the SMRT/NCoR (silencing mediator retinoid and thyroid hormone receptors/nuclear receptor corepressors), has been reported as the genetic cause of Pierpont syndrome. Here, we used CRISPR-cas9 technology to generate a mutant mouse with the Y446C mutation in Tbl1xr1, which is also present in Pierpont syndrome. Several aspects of the phenotype were studied in the mutant mice: growth, body composition, hearing, motor behavior, thyroid hormone state and lipid and glucose metabolism. The mutant mice (Tbl1xr1Y446C/Y446C) displayed delayed growth, altered body composition with increased relative lean mass and impaired hearing. Expression of several genes involved in fatty acid metabolism differed in white adipose tissue, but not in liver or muscle of mutant mice compared to wild-type mice (Tbl1xr1+/+). No difference in thyroid hormone plasma concentrations was observed. Tbl1xr1Y446C/Y446C mice can be used as a model for distinct features of Pierpont syndrome, which will enable future studies on the pathogenic mechanisms underlying the various phenotypic characteristics.
Role of non-coding RNAs on liver metabolism and NAFLD pathogenesis
Authors: Qian Gene , Morral Núria 
Published: April 2022

Abstract
Obesity and type 2 diabetes are major contributors to the growing prevalence of non-alcoholic fatty liver disease (NAFLD), a chronic liver condition characterized by the accumulation of fat in individuals without a significant amount of alcohol intake. The NAFLD spectrum ranges from simple steatosis (early stages, known as NAFL) to non-alcoholic steatohepatitis, which can progress to fibrosis and cirrhosis or hepatocellular carcinoma. Obesity, type 2 diabetes and NAFLD are strongly associated with insulin resistance. In the liver, insulin resistance increases hepatic glucose output, lipogenesis and very-low-density lipoprotein secretion, leading to a combination of hyperglycemia and hypertriglyceridemia. Aberrant gene expression is a hallmark of insulin resistance. Non-coding RNAs (ncRNAs) have emerged as prominent regulators of gene expression that operate at the transcriptional, post-transcriptional and post-translational levels. In the last couple of decades, a wealth of studies have provided evidence that most processes of liver metabolism are orchestrated by ncRNAs. This review focuses on the role of microRNAs, long non-coding RNAs and circular RNAs as coordinators of hepatic function, as well as the current understanding on how their dysregulation contributes to abnormal metabolism and pathophysiology in animal models of insulin resistance and NAFLD. Moreover, ncRNAs are emerging as useful biomarkers that may be able to discriminate between the different stages of NAFLD. The potential of ncRNAs as therapeutic drugs for NAFLD treatment and as biomarkers is discussed.
Feasibility of double sleeve lobectomy after neoadjuvant chemotherapy in patients with non-small-cell lung cancer
Authors: Bao Yi , Jiang Chao , Wan Ziwei , Wang Yang , Zhong Yifan , Deng Jiajun , She Yunlang , Jiang Lei , Hu Xuefei , Zhu Yuming , Yu Bentong , Chen Chang 
Published: April 2022

Abstract

OBJECTIVES
This study intends to appraise the feasibility of double sleeve lobectomy after neoadjuvant chemotherapy in central non-small-cell lung cancer with bronchovascular aggression.

METHODS
This retrospective study included non-small-cell lung cancer patients who received double sleeve lobectomy from January 2014 to June 2020. Patients were divided into 2 groups: the neoadjuvant chemotherapy group and the non-neoadjuvant chemotherapy group. Demographic data and perioperative outcomes were compared between these 2 groups.

RESULTS
Of the 110 patients who received double sleeve lobectomy during this period, 35 patients (31.8%) received neoadjuvant chemotherapy. Compared with the non-neoadjuvant chemotherapy group, patients who received neoadjuvant chemotherapy were associated with younger age (P = 0.026), smaller pathologic tumour size (P = 0.005), higher forced expiratory volume in 1 s (P = 0.007), higher forced expiratory volume in 1 s of predicted value (P = 0.005) and higher clinical stage (P &lt; 0.001). In the neoadjuvant chemotherapy group, 18 patients (51.4%) attained a partial response and 17 patients (48.6%) achieved stable disease. The postoperative hospital stays (P = 0.042) and chest tube drainage duration (P = 0.030) were longer in the neoadjuvant chemotherapy group and other perioperative performances were similar between these 2 groups. No statistically significant difference was reported in postoperative complications and mortality between these 2 groups.

CONCLUSIONS
The intraoperative performance and postoperative outcomes of double sleeve lobectomy following neoadjuvant chemotherapy were similar to direct surgery, indicating that double sleeve lobectomy after neoadjuvant chemotherapy is feasible and safe in central lung cancer involving both the pulmonary artery and bronchus.
Polymorphisms in Schizophrenia-Related Genes Are Potential Predictors of Antipsychotic Treatment Resistance and Refractoriness
Authors: Zazueta Alejandra , Castillo Tito , Cavieres Álvaro , González René , Abarca Maximiliano , Nieto Rodrigo R , Deneken Javier , Araneda Cristian , Moya Pablo R , Bustamante M Leonor 
Published: April 2022

AbstractBackgroundApproximately 30% of individuals with schizophrenia (SZ) are resistant to conventional antipsychotic drug therapy (AP). Of these, one-third are also resistant to the second-line treatment, clozapine. Treatment resistance and refractoriness are associated with increased morbidity and disability, making timely detection of these issues critical. Variability in treatment responsiveness is partly genetic, but research has yet to identify variants suitable for personalizing antipsychotic prescriptions.MethodsWe evaluated potential associations between response to AP and candidate gene variants previously linked to SZ or treatment response. Two groups of patients with SZ were evaluated: one receiving clozapine (n = 135) and the other receiving another second-generation AP (n = 61). Single-nucleotide polymorphisms (SNPs) in the genes OXT, OXTR, CNR1, DDC, and DRD2 were analyzed.ResultsSeveral SNPs were associated with response vs. resistance to AP or clozapine.ConclusionsThis is the first study of its kind, to our knowledge, in our admixed Chilean population to address the complete treatment response spectrum. We identified SNPs predictive of treatment-resistant SZ in the genes OXT, CNR1, DDC, and DRD2.
Quadrilateral layout generation and optimization using equivalence classes of integral curves: theory and application to surfaces with boundaries
Authors: Shepherd Kendrick M , Gu Xianfeng David , Hiemstra René R , Hughes Thomas J R 
Published: April 2022

Abstract
Extracting quadrilateral layouts from surface triangulations is an important step in texture mapping, semi-structured quadrilateral meshing for traditional analysis and spline reconstruction for isogeometric analysis. Current methods struggle to yield high-quality layouts with appropriate connectivity between singular nodes (known as “extraordinary points” for spline representations) without resorting to either mixed-integer optimization or manual constraint prescription. The first of these is computationally expensive and comes with no guarantees, while the second is laborious and error-prone. In this work, we rigorously characterize curves in a quadrilateral layout up to homotopy type and use this information to quickly define high-quality connectivity constraints between singular nodes. The mathematical theory is accompanied by appropriate computational algorithms. The efficacy of the proposed method is demonstrated in generating quadrilateral layouts on the United States Army’s DEVCOM Generic Hull vehicle and parts of a bilinear quadrilateral finite element mesh (with some linear triangles) of a 1996 Dodge Neon.
Job Satisfaction and Citizen Satisfaction with Street-level Bureaucrats: Is There a Satisfaction Mirror?
Authors: Petrovsky Nicolai , Xin Ge , Yu Jinhai 
Published: April 2022

AbstractIt is often argued that employees satisfied with their jobs perform better, which in turn will lead customers to be more satisfied. Private sector studies have found support for this “satisfaction mirror” hypothesis. Our study is the first to provide direct, individual-level evidence of its existence in the public sector. We conducted an original survey of village officials in small, rural Chinese villages, and local citizens interacting with them. Village officials are charged with delivering nearly all types of public services to citizens. They are typical street-level bureaucrats, directly interacting with citizens with a degree of discretion. We focus on the senior village official, known as village director. We link the responses of 949 citizens to their corresponding 96 village directors to test the connection between job satisfaction and individual citizens’ satisfaction with these village officials’ work. Using structural equation models and causal mediation modeling (all N = 949), we find evidence in accordance with a “satisfaction mirror.” To assess potential social desirability bias, we conduct a list experiment. Taking this into account and relying on an external performance measure still yields a substantively meaningful estimate of a “satisfaction mirror.” Our study theoretically and empirically identifies the linkage between job satisfaction of street-level bureaucrats and citizen satisfaction as a key aspect of citizen–state relations.
Responsibility and Community: Narrating the Individual and the Collective in Pandemic Times
Authors: Gilbert Pamela K 
Published: April 2022

Abstract
Epidemics are times of negotiation between the individual and the collective. The British realist novel, with its emphasis on possessive individualism, turns in the mid-nineteenth century to engage a larger population brought into view, in large part, by the emergence of statistical models of public health. Dickens is critically engaged in this process in Bleak House, which shows the difficulties of negotiating between the plot of individual agency and representing collective suffering and responsibility. Moreover, it highlights one of the major problems of defining such a collective. At a moment when Britons were beginning to understand themselves as part of a worldwide system, specifically in the light of pandemics such as cholera, what is the definition of the society to which one belongs and has responsibility? Dickens reaches for inclusion in his insistence on the linkage between events and bodies in England, but does so in part by implying that other, racialized, bodies – in Borrioboola-gha for example – are beyond that collective and its concerns. In so doing, he appeals to the notion of an ethnically coherent nation-state that was gaining ground in the period. Now we, supposedly beyond the nation-state model, find that we must think about global community within the terms of COVID-19 (and climate change) – precisely when regressive fantasies of the self-enclosed, homogenous nation are being peddled by some of the most politically reactionary governments the West has seen in many decades. This essay uses Dickens to think about the problems and opportunities of representing our global interdependence.
‘Monstrous Tumours’: Elephantiasis between Disability and Contagion in British India, 1850–1950
Authors: Nair Aparna 
Published: April 2022

Abstract
One of the more distinctive disabling illnesses common to certain parts of India is lymphatic filariasis. A mosquito-borne viral infection, filariasis often results in severely debilitating swellings and subsequent disability if undiagnosed and untreated, with significant social consequences. Elephantiasis has a unique trajectory in each individual living with it, and can be in equal parts chronic, latent, punctuated and disabling. When Europeans began exploring and eventually colonizing South Asia and the Caribbean, they were fascinated and repelled by this disease. This paper will explore the discourses of contagion and disability around lymphatic filariasis in the colony – and will track how this condition was produced as a racialized contagion. I begin by describing the broader histories of this disease, and how it came to be understood and represented in precolonial texts and art and move on to early modern travellers’ descriptions of the disease. I then describe how biomedicine came to understand the disease, and how the filarial body was put on display as material representation of both contagion and disability.
A CRASH simulation of the contribution of binary stars to the epoch of reionization
Authors: Ma Qing-Bo , Fiaschi Silvia , Ciardi Benedetta , Busch Philipp , Eide Marius B 
Published: April 2022

ABSTRACT
We use a set of three-dimensional (3D) radiative transfer simulations to study the effect that a large fraction of binary stars in galaxies during the epoch of reionization has on the physical properties of the intergalactic medium (i.e. the gas temperature and the ionization state of hydrogen and helium), on the topology of the ionized bubbles and on the 21 cm power spectra. Consistently to previous literature, we find that the inclusion of binary stars can speed up the reionization process of H i and He i, while He ii reionization is still dominated by more energetic sources, especially accreting black holes. The earlier ionization attained with binary stars allows for more time for cooling and recombination so that gas fully ionized by binary stars is typically colder than gas ionized by single stars at any given redshift. With the same volume averaged ionization fraction, the inclusion of binary stars results in fewer small ionized bubbles and more large ones, with visible effects also on the large scales of the 21 cm power spectrum.
The SN Ia runaway LP 398-9: detection of circumstellar material and surface rotation
Authors: Chandra Vedant , Hwang Hsiang-Chih , Zakamska Nadia L , Blouin Simon , Swan Andrew , Marsh Thomas R , Shen Ken J , Gänsicke Boris T , Hermes J J , Putterman Odelia , Bauer Evan B , Petrosky Evan , Dhillon Vikram S , Littlefair Stuart P , Ashley Richard P 
Published: April 2022

ABSTRACTA promising progenitor scenario for Type Ia supernovae (SNeIa) is the thermonuclear detonation of a white dwarf in a close binary system with another white dwarf. After the primary star explodes, the surviving donor can be spontaneously released as a hypervelocity runaway. One such runaway donor candidate is LP 398-9, whose orbital trajectory traces back ≈105 yr to a known supernova remnant. Here, we report the discovery of carbon-rich circumstellar material around LP 398-9, revealed by a strong infrared excess and analysed with follow-up spectroscopy. The circumstellar material is most plausibly composed of inflated layers from the star itself, mechanically and radioactively heated by the past companion’s supernova. We also detect a 15.4 h periodic signal in the UV and optical light curves of LP 398-9, which we interpret as surface rotation. The rotation rate is consistent with theoretical predictions from this supernova mechanism, and the brightness variations could originate from surface inhomogeneity deposited by the supernova itself. Our observations strengthen the case for this double-degenerate SNIa progenitor channel, and motivate the search for more runaway SNIa donors.
Galaxy clustering in the VVV near-IR galaxy catalogue
Authors: Soto Mario , Sgró Mario A , Baravalle Laura D , Alonso M Victoria , Nilo Castellón José Luis , Valotto Carlos , Taverna Antonela , Díaz-Giménez Eugenia , Villalón Carolina , Minniti Dante 
Published: April 2022

ABSTRACTMapping galaxies at low Galactic latitudes and determining their clustering status are fundamental steps in defining the large-scale structure in the nearby Universe. The VISTA Variables in the Vía Láctea (VVV) near-IR galaxy catalogue (VVV NIRGC) allows us to explore this region in great detail. Our goal is to identify galaxy overdensities and characterize galaxy clustering in the Zone of Avoidance. We use different clustering algorithms to identify galaxy overdensities: the Voronoi tessellations, the minimum spanning tree, and the ordering points to identify the clustering structure. We studied the membership, isolation, compactness, and flux limits to identify compact groups of galaxies. Each method identified a variety of galaxy systems across the Galactic plane that are publicly available. We also explore the probability that these systems are formed by concordant galaxies using mock catalogues. 19 galaxy systems were identified in all of the four methods. They have the highest probability to be real overdensities. We stress the need for spectroscopic follow-up observations to confirm and characterize these new structures.