bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair
Authors: Bolgi Oguz , Silva‐Garcia Maria , Ross Breyan , Pilla Esther , Kari Vijayalakshmi , Killisch Markus , Spitzner Melanie , Stark Nadine , Lenz Christof , Weiss Konstantin , Donzelli Laura , Gorrell Mark D , Grade Marian , Riemer Jan , Urlaub Henning , Dobbelstein Matthias , Huber Robert , Geiss‐Friedlander Ruth 
Published: August 2022

AbstractN‐terminal sequences are important sites for post‐translational modifications that alter protein localization, activity, and stability. Dipeptidyl peptidase 9 (DPP9) is a serine aminopeptidase with the rare ability to cleave off N‐terminal dipeptides with imino acid proline in the second position. Here, we identify the tumor‐suppressor BRCA2 as a DPP9 substrate and show this interaction to be induced by DNA damage. We present crystallographic structures documenting intracrystalline enzymatic activity of DPP9, with the N‐terminal Met1‐Pro2 of a BRCA21‐40 peptide captured in its active site. Intriguingly, DPP9‐depleted cells are hypersensitive to genotoxic agents and are impaired in the repair of DNA double‐strand breaks by homologous recombination. Mechanistically, DPP9 targets BRCA2 for degradation and promotes the formation of RAD51 foci, the downstream function of BRCA2. N‐terminal truncation mutants of BRCA2 that mimic a DPP9 product phenocopy reduced BRCA2 stability and rescue RAD51 foci formation in DPP9‐deficient cells. Taken together, we present DPP9 as a regulator of BRCA2 stability and propose that by fine‐tuning the cellular concentrations of BRCA2, DPP9 alters the BRCA2 interactome, providing a possible explanation for DPP9's role in cancer.
Exploring the antimicrobial properties of vaginal Lactobacillus crispatus against preterm birth-associated bacteria
Authors: Amabebe Emmanuel , Bhatnagar Noopur , Kamble Nitin , Reynolds Steven , Anumba Dilly O 
Published: August 2022

Lay summary
The need to develop new treatments to prevent unprompted premature delivery before 37 weeks of pregnancy remains pressing and unmet. Bacteria (Lactobacillus species) that promote vaginal health produce biochemical compounds that prevent the growth of microbes such as Gardnerella vaginalis. Overgrowth of G. vaginalis can cause vaginal infection with smelly discharge and increase a woman’s risk of sexually transmitted infections and premature delivery. In this study, we examined how normal health-promoting (L. crispatus) and potentially harmful (G. vaginalis) vaginal bacteria interact in a laboratory setting. This was in order to observe natural and effective agent(s) from L. crispatus that can hinder the growth of G. vaginalis and accompanying immune response. We observed that L. crispatus clears G. vaginalis by itself and with several biochemical compounds that it produces. Such biochemical compounds can be developed into treatment for vaginal infections and premature delivery due to infection and inappropriate immune response.
Children’s Health Insurance Coverage and Parental Immigration Status: 2015–2019
Authors: Nguyen Kevin H. , Wilson Ira B. , Wallack Anya R. , Trivedi Amal N. 
Published: August 2022

BACKGROUND AND OBJECTIVES
Rhetoric and policies aimed at restricting immigration to the United States, such as those proposed during the Trump administration, may lead to reduced enrollment in Medicaid for children of immigrants, even those who were legally eligible. This study assessed how children’s health insurance coverage changed before versus during the Trump administration by parental immigration status.

METHODS
Using American Community Survey data, we compared changes in rates of uninsurance and Medicaid enrollment for children in the United States before (2015 to 2016) versus during (2017 to 2019) the Trump administration. Children were categorized by parental immigration status: citizen children with US-born parents, citizen children with naturalized parents, children from mixed-status families, or noncitizen children.

RESULTS
The study population included 2 963 787 children between 2015 and 2019, representing approximately 64 million children annually. Throughout our study period, uninsurance rates for children from mixed-status families and noncitizen children were higher than citizen children with United States-born parents. Beginning in 2017, there were significant increases in uninsurance among children from mixed-status families (0.48 percentage points [PP], 95% confidence interval [CI]: 0.06 to 0.91) that increased to 1.48 PP (95% CI: 0.98 to 1.99) by 2019 when compared with concurrent trends among citizen children with US-born parents. Changes were accompanied by significant decreases in Medicaid enrollment by 2019 (−0.89 PP, 95% CI: −1.62 to −0.16).

CONCLUSIONS
There were substantial disparities in uninsurance rates by parental immigration status. Compared with citizen children with US-born parents, uninsurance rates among children from mixed-status families significantly increased between 2017 and 2019, with the magnitude of disparity widening over time.
Multiple primary malignant neoplasms of the mouth and oropharynx
Authors: Kropotov M. A. , Yakovleva L. P. , Zhukova L. G. , Agabekyan G. O. , Khodos A. V. , Safarov D. A. , Gavrishchuk P. A. , Tigrov M. S. , Vyalov A. S. 
Published: August 2022

Introduction. Probability of development of multiple primary tumors in patients who received treatment due to head and neck cancers varies between 5.6 and 35.9 % per different sources. moreover, treatment capabilities are severely limited by postoperative anatomical changes and previous radiation therapy, and the second tumor frequently causes death in these patients.The study objective is to identify the epidemiological features of the development of synchronous and metachronous primary multiple tumors in the head and neck.Materials and methods. The article analyzes data on 103 patients with multiple primary tumors who received treatment due to tumors of the head and neck between 1991 and 2020 at the N.N. Blokhin National medical Research Center of Oncology and A.S. Loginov Moscow Clinical Scientific Center.Results. During the study, typical locations of metachronous tumors in patients who received treatment due to primary malignant tumors of the head and neck were determined, duration of development of multiple primary tumors, treatment methods and survival rates were analyzed.Conclusion. Due to high risk of multiple primary tumors in patients who received treatment due to malignant tumors of the head and neck in the next 5 plus years, it is expedient to observe these patients during their whole lifetime. Considering typical locations of metachronous tumors, examination during dynamic observation should include instrumental methods such as panendoscopy. Surgical treatment should involve the whole spectrum of minimally invasive interventions including CO2 laser surgery and transoral robot-assisted interventions.
Kebijakan Pemerintah terhadap Pelaksanaan Majelis Taklim Di Banjarmasin
Authors: Zaidah Yusna , Sulistyoko Arie , Jabbar Ibnu Haikal 
Published: August 2022

bstract: During the pandemic, Majelis ta'lim, which is one form of community-based worship, is encountering difficulties in its execution. The actions of the majelis ta'lim, or collective meetings of many masses, create potential for inconsistencies between field conditions and those that should be governed by policy, resulting in activities that are supposed to be safe instead risking Covid-19 transmission.The theory of the policy application model, which includes communication, resources, tendencies, and ideal bureaucratic structures for the creation of successful policy implementation, was not completely fulfilled in the implementation of the policy for accelerating the handling of Covid-19 during the pandemic at the majelis ta'lim in the city of Banjarmasin during the pandemic. Starting with a lack of communication, the availability of resources, both adequate staff and clear and detailed information on the implementation, the organizers' authority that has yet to be fully maximized, and facilities that are not supportive, the organizers' and congregation's characteristics, and the implementation of technical procedures that have yet to be fully implemented. This occurred as a result of difficulties on the field caused by elements of the organizers and the majelis ta'lim congregation. Abstrak: Majelis ta’lim yang merupakan salah satu bentuk implementasi kegiatan peribadatan oleh masyarakat kini mengalami tantangan dalam penyelenggaraannya di masa pandemi. Kegiatan majelis ta’lim yang kolektif dengan banyak massa membuka peluang untuk terjadinya ketidaksesuian antara keadaan lapangan dengan yang seharusnya diatur kebijakan, sehingga kegiatan yang diharapkan dapat berlangsung dengan aman justru dapat beresiko terjadi penularan Covid-19. Penerapan kebijakan percepatan penanganan Covid-19 selama pandemi pada majelis ta’lim di kota Banjarmasin dilihat dari teori model penerapan kebijakan yang meliputi komunikasi, sumber daya, kecenderungan dan struktur birokrasi yang ideal untuk terciptanya keberhasilan penerapan kebijakan ternyata tidak terpenuhi secara menyeluruh. Mulai dari kurangnya komunikasi, ketersediaan sumber daya baik itu staf yang memadai, Informasi penyelenggaraan yang jelas dan rinci, kewenangan penyelenggara yang masih belum maksimal, dan fasilitas yang kurang mendukung, kemudian karakteristik penyelenggara maupun jemaah, serta penerapan teknis prosedur yang belum sepenuhnya. Hal ini terjadi dikarenakan adanya kendala di lapangan yang disebabkan oleh unsur penyelenggara dan jemaah majelis ta’lim.
Strategi Penyidik Polri Dalam Mengungkap Motif Dan Modus Operandi Pelaku Tindak Pidana Narkoba Di Indonesia
Authors: Rumainur Rumainur 
Published: August 2022

Abstract: Basically, drug crimes are real and exist around our lives. Therefore, every individual in society must be vigilant and declare war on drugs. Many modus operandi is carried out by perpetrators and drug crime syndicates to deceive law enforcement officials. In addition, the motives of the perpetrators cannot be underestimated or only because of economic factors or just looking for profit, but it is possible that there are other indications. We can see that the perpetrators continue to be arrested, but the circulation of drugs continues to occur with various new modus operandi and seems to be unstoppable. This is certainly a shared thought and a material for reflection for the Indonesian people to rise up against drugs. Abstrak: Pada dasarnya kejahatan narkoba itu adalah nyata adanya dan ada disekitar kehidupan kita. Oleh karenanya setiap individu masyarakat harus waspada dan menyatakan perang melawan narkoba. Banyak modus operandi dilakukan oleh para pelaku dan sindikat kejahatan narkoba untuk mengelabui apparat penegak hukum. Selain itu motif para pelaku, juga tidak bisa dipandang sebelah mata atau hanya sekedar karena faktor ekonomi ataupun hanya sekedar mencari keuntungan, tetapi tidak menutup kemungkinan ada indikasi lain. Kita bisa melihat pelaku terus dilakukan penangkapan, namun peredaran narkoba terus saja terjadi dengan berbagai modus operandi baru dan seolah-olah tidak terbendung lagi. Ini tentunya menjadi pemikiran bersama dan sebagai bahan renungan bagi masyarakat Indonesia untuk bangkit melawan narkoba
Analisis metode evaluasi koleksi sebagai acuan kegiatan pengembangan koleksi (UPT Balai Informasi Teknologi LIPI dan Perpustakaan IAIN Syekh Nurjati Cirebon)
Authors: Yusuf Rahmani 
Published: August 2022

Pendahuluan. Penelitian ini bertujuan untuk mengkaji metode evaluasi koleksi yang bisa diterapkan dalam proses pengembangan koleksi di perpustakaan. Metode evaluasi koleksi yang dikemukakan dalam pembahasan ini, yaitu collection-centered yang diterapkan oleh Perpustakaan IAIN Syekh Nurjati Cirebon pada prosesnya dengan melakukan tiga jenis, yaitu pencocokan pada daftar (list checking), pendapat pakar serta berdasarkan standar koleksi. Kemudian Pemetaan yang diterapkan oleh perpustakaan UPT BIT-LIPI dalam prosesnya melewati proses pada koleksi yang berdasarkan koleksi pada jenis, tahun terbit, subyek, dan bahasa. Metode penelitian. Metode yang digunakan dalam penelitian ini adalah studi literatur yang mana data diperoleh dari buku, jurnal, artikel, majalah, serta referensi karya ilmiah lainnya yang berkaitan dengan pengembangan dan evaluasi koleksi. Terdapat 3 tahapan dalam proses pengumpulan data yaitu editing, organizing, dan findingData analisis. Analisis data yang digunakan pada tulisan ini menggunakan teori atau pendapat Edwards. G. Evans dalam pengembangan dan evaluasi koleksi perpustakaan, sehingga dalam proses analisa untuk mencari kebenaran melalui pendapat ahli bisa dijadikan sebagai acuan.Hasil dan Pembahasan. Perpustakaan IAIN Syekh Nurjati Cirebon menggunakan evaluasi berdasarkan metode collection-contered. Yang terdapat tiga jenis di dalamnya, yaitu pencocokan pada daftar yang sudah dibuat oleh pustakawan sebelumnya, lalu meminta pendapat pakar baik kepada dosen setempat ataupun orang yang memiliki keahlian dibidang tertentu dan berdasarkan standar koleksi. Sedangkan perpustakaan UPT Balai Informasi Teknologi LIPI mengevaluasi koleksi dengan menerapkan cara pemetaan pada koleksi yang biasa digunakan perpustakaan UPT BIT-LIPI mengimplikasikan dua fitur yaitu berbasis dengan koleksi dan berbasis kepada pengguna. Cara ini berfokus pada jenis koleksi, tahun terbit, bidang atau subjek, dan bahasa.Kesimpulan dan Saran. Masih belum ada metode evaluasi koleksi yang cukup dengan sendirinya, lalu pendekatan gabungan atau kombinasi dari berbagai macam metode adalah yang paling efektif sampai saat ini. Sehingga dengan melakukan gabungan dari beberapa metode tadi sangat diharapkan nantinya dapat mengasilkan masukan yang tepat dan sesuai dengan kebutuhan pengunjung perpustakaan.
Experimental Investigation of the Effects of Fluid Viscosity on Electrical Submersible Pumps Performance
Authors: Monte Verde W. , Kindermann E. , Biazussi J. L. , Estevam V. , Foresti B. P. , Bannwart A. C. 
Published: August 2022

Summary
Electrical submersible pumps (ESPs) are an important artificial lift method used in oil production. ESPs can provide high production flow rate, are flexible, and can be installed in highly deviated wells, subsea deepwater wells, or on the seabed. ESP performance is generally characterized by manufacturers using only water as fluid. However, oil properties are very different from water and significantly alter the pump’s performance. Operating ESPs with viscous fluids leads to degraded pump performance. Therefore, knowing the ESP’s performance when pumping viscous fluid is essential to properly design the production system. In this work, we present an experimental study of ESP performance operating with viscous flow. A total of six ESP models were tested, operating at four different rotational speeds and 11 viscosities, resulting in a comprehensive database of more than 5,800 operating conditions. This database contributes to the literature given the lack of available data. We also perform a phenomenological analysis on the influence of operational parameters, such as viscosity, rotational speed, specific speed, and rotational Reynolds number. The database and analyses performed are central for future models predicting the viscous performance of ESPs. The results from our investigation and tests showed that the increase in viscosity causes (1) a reduction in the head and (2) an increase in drive power, resulting in (3) a sharp decrease in efficiency. However, increasing rotational speed tends to mitigate this performance degradation. Efficiency and flow rate correction factors are virtually independent of the flow rate within the recommended operating region. This is not true for the head correction factor, which is not constant. The pump geometry seems to influence its performance as ESPs with higher specific speed are less impaired by viscous effects. The database obtained in the present work is available in the data repository of the University of Campinas, at the address presented by Monte Verde et al. (2022).
Dynamic Adsorption of Enzyme on Sand Surfaces- An Experimental Study
Authors: Udoh Tinuola , Benson Utibeabasi 
Published: August 2022

Abstract
Enzyme can reduce interfacial tension between oil and water thereby mobilising more oil than would originally be produced but its adsorption on the porous rock surfaces reduces its efficiency. This study presents experimental investigation of dynamic adsorption of enzyme on sand surfaces. The experiment was carried out at varied brine salinities and enzyme concentrations on different sand grain sizes. The concentration depletion method that accounts for the difference in enzyme concentrations in solution before and after its contact with the sand was used to determine the enzyme adsorption on relevant surfaces. The effluent sample from the adsorption process was collected after every three minutes until equilibrium was reached and the final concentration of the enzyme in the effluent solutions was measured and used to determine its adsorbed concentration on the sand surfaces. The results of this study show that increase in concentration of enzyme results in increase in its adsorption on sand surfaces. Also, increase in brine salinity increased enzyme adsorption on the sand surfaces but increase in sand grain size however reduced its adsorption. The result of this study is relevant in the design of enzyme enhanced oil recovery process.
Pressure Buildup Test Analysis Procedure of a Vertical Well Completed Within a Pair of Inclined Sealing Faults
Authors: Olabi Paul , Adewole Steve 
Published: August 2022

Abstract
Pressure buildup test analysis has been used to investigate near wellbore environment, estimate reservoir pressure and reveal external reservoir boundary types. However, despite of these benefits no consideration has been given for the angle of inclination of the faults or boundaries within which the well is completed. The angle of inclination of the boundaries of a reservoir has a significant impact on the pressure behavior and performance of a well. Knowledge of the inclination angle of the faults assist in well placement for optimum production.
The objective of this paper, therefore, is to develop a procedure for calculating the angle of a well completed within a pair of inclined sealing faults using pressure buildup test analysis.
A well completed in an infinite-acting reservoir produces number of images inversely proportional to the angle of inclination and dependent on nature of the faults. This number of images, n, can also be related to the angle at which the faults are inclined. The principle of superposition is used to aggregate pressure drop history of a vertical shutin after a constant rate of production. Pressure buildup test procedure was developed from the total pressure expression following the rate history.
The procedure considered fault angle and distances from an object well of every image formed because of the inclination of the sealing faults.
The buildup test procedure developed shows linear partial variation of Horner ratio at early shutin time and late shutin time, assuming constant rate of production before shut in. The coefficient of the early time Horner's ratio is the early flow time slope. The late time Horner's ratio has coefficient which is the product of the early time slope and the number of images formed due to sealing faults angle.
The result shows that that the model is only valid for long shutin time, and the second slope must be gotten at the late time region for higher accuracy. Finally, the procedure does not depend on well design or distances of the images from the object well.
The analysis procedure developed here can be used to estimate the angle of inclination of two faults within which a well is completed. Near wellbore characterization is also possible. Decision on well location for optimum well production or injection can be made from the angle of inclination of the faults.
The Diagnostics and Recompletion Strategy of a Well with Sustained Casing Pressure
Authors: Elendu Chidi , Nwamara Nnaemeka , Alinnor Chidubem , Enekhai Henry , Ojukwu Ihechi , Ayoo James , Abolarin Olugbenga 
Published: August 2022

Abstract
Well sustained casing pressure signifies failure in the barrier envelop of any well and results in situations where pressure is observed or recorded in the annuli of a well and this pressure usually rebounds after bleed down. This phenomenon is a precursor to environmental and safety risk to the global oil and gas industry and presents a challenging situation that requires monitoring to understand the severity and management strategy. It is assessed to be a well integrity issue due to noncompliance to well barrier concept. It has become increasingly critical to address wells with sustained casing pressure (SCP) in view of the regulations guiding the industry and the operating environment which is experiencing an escalation of third-party activities. A bridge of well safety portends serious safety, health, environmental, operational, and integrity risks. Well PO-21 was completed as a single string, horizontal completion in the Q-10/PO-20 reservoir in 2004. Although, the well exceeded the production targets, it was subsequently shut-in in 2007 due to SCP. The initial well work attempts were carried out but were ineffective in resolving the SCP concerns: the well works carried out to isolate the casing pressure include tubing hole finding and setting of pack-off to isolate the holes. These activities could not resolve the sustained casing pressure issues with the well until a comprehensive analysis of the well, using a production logging tool comprising of noise and temperature log was deployed which gave a better understanding of the challenges of the well. A Major Rig Work Over (MRWO) was subsequently carried out on well and production was restored.
The well has continued to produce. This paper sets out to explore the holistic study of well PO-21: the initial well construction – drilling (casing, cementing, etc.,) and completion (lower and upper) design and operations. It will also showcase the production and nature of the problem observed during the production, the evaluations, and diagnostics carried out to isolate the source of SCP. The step-by-step solution approach in eliminating possible sources will be discussed based on the identified issues with the well using acquired data. The paper will also focus on the MRWO operations, and the several challenging situations encountered which necessitated a management of change from the planned recompletion strategy in response to the observed well condition. The well was successfully recompleted with no loss of containment and several lessons were learnt.