bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the 5-HT2C receptor drugs RO 60-0175, WAY 161503 and mirtazepine in a preclinical model of comorbidity of cocaine addiction and depression
Authors: Jastrzębska Joanna , Frankowska Małgorzata , Smaga Irena , Hubalewska-Mazgaj Magdalena , Suder Agata , Pieniążek Renata , Przegaliński Edmund , Filip Małgorzata 
Published: April 2022

Abstract
Epidemiological data indicate a high rate of comorbidity of depression and cocaine use disorder (CUD). The role of 5-HT2C receptors in the mechanisms responsible for the coexistence of CUD and depression has not been investigated. Here, we combined bilateral olfactory bulbectomy (OBX), an animal model of depression, with intravenous cocaine self-administration and extinction/reinstatement in male rats to investigate two 5-HT2C receptor agonists (Ro 60–0175 (RO) and WAY 161503 (WAY)) and the 5-HT2C-receptor preferring antagonist mirtazapine (MIR; an antidepressant), with the goal of determining whether these drugs alter cocaine-induced reinforcement and seeking behaviors. Additionally, neurochemical analyses following cocaine self-administration and its abstinence period in the brain structures in OBX rats and SHAM-operated controls were performed.Acute administration of RO reduced, while WAY non-significantly attenuated cocaine reinforcement in OBX and SHAM rats. Moreover, RO or WAY protected against cocaine-seeking behavior after acute repeated drug administration during extinction training in OBX and SHAM rats. By contrast, acutely administered MIR did not alter cocaine reinforcement in both rat phenotypes, while acute (but not repeated) pretreatment reduced cocaine seeking in OBX and SHAM rats. In neurochemical analyses, cocaine reinforcement increased 5-HT2C receptor levels in the ventral hippocampus; this effect was enhanced by preexisting depression. The 10-daily cocaine abstinence from self-administration reduced 5-HT2C receptor expression in the dorsolateral striatum but coexistence of depression and CUD enhanced local receptor expression. The present study is an extra recommendation to support current development of pharmacological strategies with drugs targeting the 5-HT2C receptor for the treatment of comorbid depression and CUD.
Transcatheter angiographic embolization of percutaneous nephrolithotomy-related bleeding: A single-center experience
Authors: Xiao Fan , Xun Yang , Hu Weijie , Xia Qidong , Zhang Jiaqiao 
Published: April 2022

Abstract
Background: To evaluate the clinical characteristics and angiographic features of transcatheter angiographic embolization (TAE) in patients with active bleeding after percutaneous nephrolithotomy (PCNL).Methods: Between 2009 and 2018, 45 patients who underwent TAE for hemorrhage control after PCNL were reviewed retrospectively. Patient clinical characteristics and angiographic features of TAE were analyzed.Results: Of the 3148 patients, 45 (1.4%) patients were treated with TAE after PCNL. The interval from the bleeding episode to TAE was 3 days (1,6). Arterial laceration, arteriovenous fistula, and negative angiographic finding was found in 28 (62.2%), 7 (15.6%), and 10 patients (22.2%). Thirty-five patients (92.1%) achieved primary clinical success. The median corrected hemoglobin decrease from bleeding episode to TAE was 52 g/L (25.25, 71.00). The median corrected hemoglobin decrease rate from bleeding episode to TAE was 13.11 g/L·d (5.60, 26.12). The hemoglobin decrease from bleeding episode to TAE was lesser in negative angiographic patients (28.50 (10.75,51.25) g/L VS 53.7 (35.0,73.13) g/L) than in positive angiographic patients (P<0.05).Conclusions: TAE is a safe and effective treatment for post-PCNL bleeding patients. Previous kidney surgery is associated with a higher risk of TAE. Patients with bleeding from multiple negative angiographic findings can be considered for prophylactic embolization.
DETERMINANTS OF ISLAMIC BANKING ACCEPTANCE AS A SINGLE BANKING SYSTEM IN ACEH
Authors: Mirzal Husnul 
Published: April 2022

Abstrak: Penelitian ini bertujuan untuk melihat faktor-faktor yang mempengaruhi penerimaan terhadap implementasi perbankan syariah sebagai sistem tunggal perbankan di Provinsi Aceh, Indonesia. Penelitian menggunakan data primer yang dikumpulkan dari 169 responden dengan metode penyebaran kuesioner. Data dianalisis menggunakan Partial Least Square Structural Equation Modelling (PLS-SEM). Hasil dari penelitian menunjukkan bahwa sikap konsumen, kesiapan untuk mentaati hukum Islam, Persepsi terhadap Manfaat Perbankan Syariah dan Persepsi terhadap Inovasi Perbankan Syariah merupakan faktor-faktor determinan yang mempengaruhi niat menggunakan bank syariah yang merupakan salah satu indikator penerimaan Perbankan Syariah sebagai sistem tunggal perbankan di Aceh. Sedangkan pengetahuan tentang Perbankan Syariah tidak memiliki pengaruh signifikan. Hasil dari penelitian ini diharapkan bermanfaat kepada pemerintah, stakeholder perbankan syariah dan regulator perbankan syariah dalam menyusun kebijakan perbankan syariah sebagai sistem tunggal perbankan di Aceh, Indonesia. Selanjutnya penelitian ini diharapkan bermanfaat dalam menambah literatur akademik bidang ekonomi dan keuangan Islam.
Abstract: This study investigates the factors affecting Islamic banking acceptance as a single banking system in Aceh, Indonesia. It used primary data collected from 169 respondents using a self-administered structured questionnaire. Empirical data were analysed using Partial Least Squares Structural Equation Modelling (PLS-SEM). The study results show that consumer attitude, readiness to comply with Islamic law, perceived benefit of Islamic Banking, and perceived innovativeness of Islamic Banking were critical determinants of intention to use Islamic Banking as the single banking system in Aceh, Indonesia. The least influential factor was knowledge of Islamic Banking. This study's results are expected to help the government, banking and financial stakeholders, and policymakers to plan appropriate policy in implementing Islamic Banking as a single banking system in Aceh, Indonesia. Furthermore, the study will contribute to existing academic literature, especially in Islamic Banking.
An investigation on effect of variation of mass flow rate and number of collectors on yearly efficiency of single slope solar still by incorporating N similar photovoltaic thermal flat plate collectors
Authors: Singh Vivek , Kumar Rakesh , Sharma R. K. , Singh Surya Prakash , Sinhmar Harender , Singh Desh Bandhu 
Published: April 2022

Abstract
The effect of variation of mass flow rate and number of collectors (N) on the yearly efficiency of a single slope solar still by incorporating series connected N similar photovoltaic thermal flat plate collectors (NPVTFPCSS) has been investigated, keeping a constant water depth in basin as 0.14 m. The various parameters have been calculated, taking into account all four types of weather conditions for New Delhi using computing code developed in MATLAB-2015a. All equations and required data have been fed to the computing code for evaluating different relevant parameters. It has been concluded that the value of all types of annual efficiencies, except annual electrical efficiency, diminishes with increase in the value of at a selected value of N until = 0.10 kg/s and then becomes almost constant. Optimal values of N from annual overall exergy efficiency and annual overall thermal efficiency viewpoints have been found as four and ten respectively.
Simulations of the climate change and its effect on water resources in the Palma River basin, Brazil
Authors: Ribeiro C. L. C. , Diotto A. V. , Thebaldi M. S. , Rodrigues J. A. M. , Viola M. R. 
Published: April 2022

Abstract
Anthropic and natural factors can affect the water availability in a basin, making necessary the use of tools that allow the simulation of future scenarios. Considering that future climate change can affect water resources, the objective of this study was to evaluate the sustainability of the Palma River basin, located in the Tocantins state, Brazil, throughout the century, under scenarios of climate change and increase in irrigated area. Future runoff was simulated using the SWAT model, considering the Eta/HadGEM2-ES and Eta/MIROC5 climate models and the RCPs 4.5 and 8.5 emission scenarios. The crop irrigation requirement was simulated using the AquaCrop model. A model was created in STELLA software, where the water supply and demand data in the basin were entered, and the sustainability index (SI) was calculated, whose results were statistically analyzed through trend and correlation tests. HadGEM 8.5 was the most unsustainable scenario. MIROC 4.5 and MIROC 8.5 scenarios showed higher growth of unsustainable months over time. A trend of decreasing SI and increasing unsustainable months was observed in most scenarios. The results found can assist in the decision-making of water resource managers, to promote the mitigation of climate change effects in the basin.
Asiaticoside Enhances the Osteoblast Potential of LPS-induced Periodontal
Ligament Stem Cells through TLR4/NF-κB Pathway
Authors: Zou Xuan , Yu Kaitao , Chu Xiaoyang , Shu Yao , Yang Lili , Wang Chenglong 
Published: April 2022

Objective:
Asiaticoside (AS), an active compound extracted from Centella asiatica, can promote
the osteogenic differentiation of human periodontal ligament cells. In this study, we investigated the
impact of AS on lipopolysaccharide (LPS)-induced osteoblast differentiation and inflammatory response
in human periodontal ligament stem cells (hPDLSCs) and its possible mechanisms.

Method:
hPDLSCs were treated with LPS to establish a model mimicking periodontitis and then administered
with different concentrations of AS (30, 60, and 120 μM). Flow cytometry and CCK-8 were conducted
to assess cell apoptosis and proliferation rates, ELISA to detect the levels of inflammatory factors
(IL-1β, IL-8, and TNF-α) in the cell supernatant, and Western blot to determine the expression of osteoblast
differentiation proteins (Runx2, and OPN) and TLR4/NF-κB signaling pathway proteins (TLR4,
MyD88, P65, p-P65) with ALP and Alizarin red staining conducted.

Results:
LPS induced apoptosis of hPDLSCs, and inhibited proliferation and osteoblast differentiation
when increasing the levels of inflammatory factors. However, these alterations were restored upon AS
treatment dose-dependently when cell apoptosis decreased, proliferation rate increased, IL-1β, IL-8, TNF-
α levels decreased, and osteoblast differentiation enhanced. Additionally, LPS activated the TLR4/NF-κB
signaling pathway in hPDLSCs, up-regulating TLR4, MyD88, and p-P65 expression, which was abrogated
by AS.

Conclusion:
AS ameliorates LPS-induced inflammation and apoptosis in hPDLSCs through TLR4/NF-
κB pathway and that AS can be expected to become a therapeutic drug for periodontal tissue regeneration
treatment.
The Impact of the COVID-19 Pandemic on Hepatobiliary and Pancreatic Surgical Services in Singapore: Retrospective Quantitative Study
Authors: Teo Zhe Hao Timothy , Huey Cheong Wei Terence , Low Jee Keem , Junnarkar Sameer Padmakumar , Shelat Vishalkumar G 
Published: April 2022

Background
At the height of the COVID-19 pandemic, the hepatopancreatobiliary (HPB) unit had to reorganize its surgical case volume due to the rationing of health care resources. We report on a local audit evaluating the impact of COVID-19 on the HPB unit and the HPB surgical oncology practice.

Objective
The aim of this study was to review the impact of the COVID-19 pandemic on the HPB unit’s elective and emergency surgical cases. The secondary aims were to investigate the impact on the HPB surgical oncology operative case volume.

Methods
We performed a comparative audit of the HPB unit surgical case volume for January-June 2019 (baseline) and 2020 (COVID-19). Elective and emergency cases performed under general anesthesia were audited. Elective cases included hernia and gallbladder operations and liver and pancreatic resections. Emergency cases included cholecystectomies and laparotomies performed for general surgical indications. We excluded endoscopies and procedures done under local anesthesia. The retrospective data collected during the 2 time periods were compared. This study was registered in the Chinese Clinical Trial Registry (ChiCTR2000040265).

Results
The elective surgical case volume decreased by 41.8% (351 cases in 2019 compared to 204 cases in 2020) during the COVID-19 pandemic. The number of hernia operations decreased by 63.9% (155 in 2019 compared to 56 in 2020; P<.001) and cholecystectomies decreased by 40.1% (157 in 2019 compared to 94 in 2020; P=.83). The liver and pancreatic resection volume increased by 16.7% (30 cases in 2019 compared to 35 cases in 2020; P=.004) and 111.1% (9 cases in 2019 compared to 19 cases in 2020; P=.001), respectively. The emergency surgical workload decreased by 40.9% (193 cases in 2019 compared to 114 cases in 2020). The most significant reduction in the emergency workload was observed in March (41 to 23 cases, a 43.9% reduction; P=.94), April (35 to 8 cases, a 77.1% reduction; P=.01), and May (32 to 14 cases, a 56.3% reduction; P=.39); however, only April had a statistically significant reduction in workload (P=.01).

Conclusions
The reallocation of resources due to the COVID-19 pandemic did not adversely impact elective HPB oncology work. With prudent measures in place, essential surgical services can be maintained during a pandemic.

Trial Registration
Chinese Clinical Trial Registry (ChiCTR2000040265); https://tinyurl.com/ms9kpr6x
COVID-19 Vaccination and Public Health Countermeasures on Variants of Concern in Canada: Evidence From a Spatial Hierarchical Cluster Analysis
Authors: Adeyinka Daniel A , Neudorf Cory , Camillo Cheryl A , Marks Wendie N , Muhajarine Nazeem 
Published: April 2022

Background
There is mounting evidence that the third wave of COVID-19 incidence is declining, yet variants of concern (VOCs) continue to present public health challenges in Canada. The emergence of VOCs has sparked debate on how to effectively control their impacts on the Canadian population.

Objective
Provincial and territorial governments have implemented a wide range of policy measures to protect residents against community transmission of COVID-19, but research examining the specific impact of policy countermeasures on the VOCs in Canada is needed. Our study objective was to identify provinces with disproportionate prevalence of VOCs relative to COVID-19 mitigation efforts in provinces and territories in Canada.

Methods
We analyzed publicly available provincial- and territorial-level data on the prevalence of VOCs in relation to mitigating factors, summarized in 3 measures: (1) strength of public health countermeasures (stringency index), (2) the extent to which people moved about outside their homes (mobility index), and (3) the proportion of the provincial or territorial population that was fully vaccinated (vaccine uptake). Using spatial agglomerative hierarchical cluster analysis (unsupervised machine learning), provinces and territories were grouped into clusters by stringency index, mobility index, and full vaccine uptake. The Kruskal-Wallis test was used to compare the prevalence of VOCs (Alpha, or B.1.1.7; Beta, or B.1.351; Gamma, or P.1; and Delta, or B.1.617.2 variants) across the clusters.

Results
We identified 3 clusters of vaccine uptake and countermeasures. Cluster 1 consisted of the 3 Canadian territories and was characterized by a higher degree of vaccine deployment and fewer countermeasures. Cluster 2 (located in Central Canada and the Atlantic region) was typified by lower levels of vaccine deployment and moderate countermeasures. The third cluster, which consisted of provinces in the Pacific region, Central Canada, and the Prairies, exhibited moderate vaccine deployment but stronger countermeasures. The overall and variant-specific prevalences were significantly different across the clusters.

Conclusions
This “up to the point” analysis found that implementation of COVID-19 public health measures, including the mass vaccination of populations, is key to controlling VOC prevalence rates in Canada. As of June 15, 2021, the third wave of COVID-19 in Canada is declining, and those provinces and territories that had implemented more comprehensive public health measures showed lower VOC prevalence. Public health authorities and governments need to continue to communicate the importance of sociobehavioural preventive measures, even as populations in Canada continue to receive their primary and booster doses of vaccines.
Secularización y politización zapatista de las mujeres tseltales
Authors: Salazar Cruz Luz María , Leyva Méndez Gabriela 
Published: April 2022

En este artículo analizamos cambios hacia la secularización y politización de las mujeres tseltales de Ocosingo a partir de la Ley Revolucionaria de Mujeres, elaborada por las mujeres zapatistas en 1993. Observamos una transformación radical en la vida de las mujeres, y en la sociedad tseltal, identificamos un antes y un después del zapatismo en las relaciones entre mujeres y hombres tseltales. Asimismo, un empoderamiento en mujeres zapatistas a partir del proceso de secularización y politización del EZLN. Este artículo se basa en la investigación etnográfica que realizamos en el municipio de Ocosingo de 1993 a la fecha (2021).
Iturbide: Funestos recuerdos del libertador de México
Authors: IRACHETA MARÍA DEL PILAR 
Published: April 2022

Durante los dos años sucesivos de su emancipación de España, entre 1821 y 1823, la figura de Agustín de Iturbide, estuvo a la altura del heroismo y ascendió prácticamente a la categoría de divinidad. La población puso su entusiasmo y esperanza en el autor de la Independencia, lograda de manera pacífica y negociada, a través de los Tratados de Córdoba y el Plan de Iguala. Pero,
luego de su fallido gobierno como Emperador de México, Iturbide abdicó al trono y partió a su exilio en Europa. Allá se enteró de un supuesto plan de reconquista de las colonias españolas, a cargo de los países que formaban la Santa Alianza, emprendiendo su regreso a México para prestar sus servicios en caso de que dicho plan sucediera. Sin embargo, desconocía que el Congreso había promulgado el decreto del 28 de abril de 1824, impulsado por el Poder Legislativo y avalado por el Ejecutivo, declarándolo traidor y fuera de la Ley a Iturbide, siempre que se presentara bajo cualquier título en algún punto del territorio mexicano; también fue declarado enemigo público del Estado. El 14 de julio de 1824 el bergantín inglés
Spring
regresó a Iturbide a su Patria; desembarcó en Soto la Marina. El comandante de la guarnición federal, general Felipe de la Garza, a quien Iturbide le salvó una vez la vida, descubrió su llegada y le comunicó que, de acuerdo con el decreto de 28 de abril de 1824 del Congreso General, debía ser pasado por las armas inmediatamente.
Mapeo participativo y cartografía social de conocimientos culturales, históricos y arqueológicos. Recurso práctico para profesores y estudiantes universitarios
Authors: Álvarez Larrain Alina , McCall Michael K. , León Villalobos José María 
Published: April 2022

La obra compila lineamientos y herramientas para la aplicación de un enfoque de mapeo participativo y cartografía social de conocimientos culturales, históricos y arqueológicos. Está pensada como un recurso didáctico para profesores o estudiantes universitarios interesados en enseñar o aplicar este método en sus investigaciones o proyectos. Cuenta asimismo con sugerencias para una buena práctica en el trabajo con comunidades y diversos sectores sociales. Esperamos que está publicación sea un recurso valioso tanto para los estudiantes del postgrado del CIGA, como para los estudiantes de la ENES Morelia, dada la afinidad temática con los cursos allí impartidos y los temas de tesis derivados de estas instituciones.
Bai’at dalam Al-Qur’an menurut Pandangan Ibnu Katsir
Authors: Bahri Samsul , Zainuddin Zainuddin , Ismail Muhammad Husni Bin 
Published: April 2022

Bai'at is one way to show a person's form of obedience to his leader. An incomplete understanding of bai'at can cause slander among Muslims. Moving on from the problem above, the author will examine Ibn Kathir's interpretation of the verses of bai'at. This research is bibliographic and data collection is done through the mauḍū'ī method. The results of the study show that the person who betrays the bai'at to the leader on the basis of obeying Allah and the Messenger, then Allah will inflict punishment on him, on the other hand, for those who obey the bai'at in matters that are ma'ruf on the basis of obeying Allah and the Messenger, then he will get a reward from Allah swt. Imam Ibn Kathir interprets the verse of bai'at as meaning "whoever obeys the apostle, then he has obeyed Allah." Bai’at merupakan salah satu cara dalam menampakkan bentuk ketaatan seseorang terhadap pemimpinya. Pemahaman yang tidak utuh terhadap bai’at dapat menimbulkan fitnah di antara umat islam. Beranjak dari persoalan di atas, penulis akan mengkaji tentang penafsiarn Ibnu Katsir terhadap ayat-ayat bai’at. Penelitian ini bersifat kepustakaan dan dalam pengumpulan data dilakukan melalui metode mauḍū’ī. Hasil penelitian menunjukkan bahwa Orang yang mengkhianati bai’at terhadap pemimpin atas dasar mentaati Allah dan Rasul, maka Allah akan menimpa azab baginya, sebaliknya bagi yang mentaati bai’at dalam hal yang ma’ruf atas dasar menaati Allah dan Rasul, maka ia akan beroleh balasan pahala dari Allah Swt. Imam Ibnu Katsir menafsirkan ayat bai’at sama artinya dengan “barangsiapa mentaati rasul, maka dia telah menaati Allah.”
"The Dead Are Raised" (Matthew 11:5 // Luke 7:22): Resuscitation Accounts in the Gospels and Eyewitness Testimony
Authors: KEENER CRAIG S. 
Published: April 2022

Abstract
The criterion of multiple attestation supports the claim that persons believed dead were resuscitated in Jesus's ministry. One might wish to count the historiographic principle of analogy against the earliness of this tradition, but there are in fact analogies for such experiences today. It is incontrovertible that significant numbers of eyewitnesses in numerous cultures offer claims of resuscitations in theistic contexts today. Philosophic and theological explanations of these experiences vary, but the analogies suggest that one need not attribute all resuscitation accounts to late, legendary accretions.
He That Cometh in Mark 1:7 and Matt 24:30
Authors: KIRCHHEVEL GORDON D. 
Published: April 2022

Abstract
According to Mark 1:7 John the Baptist expected the coming of someone perceived as predicted in Isa 5:26–27. According to Matt 24:30 Jesus expected to come as the individual perceived in Isa 5:26–30 and the Targum (Aramaic interpretation), and so the "sign" of his coming meant the "sign" in Isa 5:26, and the "clouds" meant the "clouds" in Isa 5:30 and Targumic tradition. Messianic Isa 11:10 and Aramaic tradition inspired John 14:2– 3, and Mark 13:27 coheres dictionally with Tg. Isa 11:12. The messianic interpretation of Psalm 8 in Mark 2:10, 28 was preceded by one in 1 Cor 15:27, and the messianic interpretation of Isa 5:26–30 in Mark 13:26 was preceded by one in 1 Thess 4:13–18 ("the word of the Lord" = Isa 5:26–30).