bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gambaran strategi koping orang tua dengan anak retardasi mental
Authors: Nuralami Fatimah , Atmadja Iceu Amira Dira , Ramdhanie Gusgus Ghraha 
Published: April 2022

Background: Poor parents' coping strategy can causes behavioral disorders that occur in parents and will also have an impact on child care such as neglecting, depression in parents and social isolation in the children.Purpose: To find out how the description of coping strategy of parents with mental retardation children.Method:This study was conducted descriptive quantitative, describing coping strategies of parents with mentally retarded children in the State SDLB 2 Garut City. Its population is the elderly mentally retarded child who totaled 89 people. The number is a combination of 46 parents consisting of 43 pairs of father and mother and also 3 single parents. Sampling with total population technique. The instrument used in this study is Coping Health Inventory for Parent.Results: Shows that most of the coping strategy of parents were in the maladaptive category as many as 51.7%. Whereas in the dimensions of coping strategy, most of them showed maladaptive. As many as 55.1% in the family integrity dimension, 52.8% in the psychological stability dimension and 50.6% in the communication dimension.Conclusion: It is recommended that parents improve the coping strategy to collaborate between partners or families, maintain psychological stability and communicate with people who have the same problem or are in the middle of health. It is hoped that nurses can provide counseling to parents to help improve coping strategies.Keywords: Parents; Coping Strategy; Child; Mental RetardationPendahuluan : Strategi coping orang tua yang buruk dapat menyebabkan gangguan perilaku yang terjadi pada orang tua dan juga akan berdampak pada pengasuhan anak seperti penelantaran, depresi pada orang tua dan isolasi sosial pada anak.Tujuan: Untuk mengetahui bagaimana gambaran strategi koping orang tua dengan anak tunagrahita.Metode: Penelitian ini dilakukan secara deskriptif kuantitatif, mendeskripsikan strategi koping orang tua dengan anak tunagrahita di SDLB Negeri 2 Kota Garut. Populasinya adalah lansia anak tunagrahita yang berjumlah 89 orang. Jumlah tersebut merupakan gabungan dari 46 orang tua yang terdiri dari 43 pasang ayah dan ibu serta 3 orang tua tunggal. Pengambilan sampel dengan teknik populasi total. Instrumen yang digunakan dalam penelitian ini adalah Inventarisasi Coping Kesehatan Orang Tua.Hasil: Menunjukkan bahwa sebagian besar strategi koping orang tua berada pada kategori maladaptif yaitu sebanyak 51,7%. Sedangkan pada dimensi strategi koping sebagian besar menunjukkan maladaptif. Sebanyak 55,1% pada dimensi integritas keluarga, 52,8% pada dimensi stabilitas psikologis dan 50,6% pada dimensi komunikasi.Simpulan: Disarankan kepada orang tua meningkatkan strategi koping untuk berkolaborasi antara pasangan atau keluarga, menjaga stabilitas psikologis dan berkomunikasi dengan orang yang memiliki masalah yang sama atau berada di tengah kesehatan. Diharapkan perawat dapat memberikan konseling kepada orang tua untuk membantu meningkatkan strategi koping.
EVALUASI RASIONALITAS PENGGUNAAN OBAT ANTIHIPERTENSI PADA PASIEN PREEKLAMPSIA RAWAT INAP DI RSUD JEND. AHMAD YANI METRO PERIODE TAHUN 2019
Authors: Saputri Gusti Ayu Rai , Ulfa Ade Maria , Jannah Miftahul 
Published: April 2022

Preeklampsia didefinisikan sebagai timbulnya hipertensi disertai dengan protein urin pada usia kehamilan lebih dari 20 minggu atau segera setelah persalinan, jadi pemilihan obat yang digunakan harus aman dan efektif, sehingga penelitian ini dilakukan untuk mengetahui jenis obat yang diberikan dan dipersentase rasionalitas penggunaan obat antihipertensi pada pasien preeklampsia Rawat Inap di RSUD Jend.ahmad Yani Metro Periode 2019. Penelitian ini merupakan jenis penelitian non eksperimental, karena tidak memberikan perlakuan apapun pada subyek penelitianya. Obat antihipertensi monoterapi yang digunakan pada preeklampsia ringan adalah golongan Agonis sentral α-2 yaitu methyldopa sebesar (100%) dan obat antihipertensi monoterapi yang paling sering digunakan pada preeklampsia berat adalah golongan Calsium Channel Bloker (CCB) yaitu nifedipin sebesar (48,48%). Sedangkan untuk kombinasi 2 obat yang banyak digunakan adalah Calsium Channel Bloker (CCB) nifedipin dan Agonis Sentral α-2 methyldopa sebesar (33,33%). Rasionalitas penggunaan obat antihipertensi berdasarkan Queensland Clinical Guideline (2015) dan POGI 2016 adalah 100% tepat diagnosis ; 83,33% tepat indikasi; 83,33% tepat obat; 100% tepat dosis; 100% tepat cara pemberian; 100% tepat interval waktu pemberia dan 100% tepat pasien, dengan nilai persentase kerasionalan penggunaan antihipertensi pada pasien preeklampsia adalah 95,23%. Kata kunci : Rasionalitas, Hipertensi, Preeklampsia, Rumah Sakit Ahmad yani
FORMULASI GEL ANTI JERAWAT KOMBINASI EKSTRAK ETANOL DAUN KEMANGI (Ocimum x africanum Lour.) DAN LIDAH BUAYA (Aloe vera (L.) Burm. f.) BERBASIS SODIUM ALGINATE DAN UJI AKTIVITAS TERHADAP BAKTERI Propionibacterium acnes
Authors: Yasir Angga Saputra 
Published: April 2022

Tanaman kemangi (Ocimum x africanum Lour.) dan tanaman lidah buaya (Aloe vera (L.) Burm. f.) meupakan tanaman yang memiliki aktivitas antibakteri salah satunya dapat menghambat bakteri penyebab jerawat yaitu Propionibacterium acnes. Tanaman tersebut memilii kandungan senyawa metabolit sekunder diantaranya tanin, flavonoid, saponin, fenol, triterpenoid dan alkaloid. Penelitian ini betujuan untuk melihat formulasi sediaan gel kombinasi ekstrak daun kemangi dan lidah buaya terhadap bakteri Propionibacterium acnes. Penelitian diawali dengan uji pendahuluan kombinasi ekstrak daun kemangi dan lidah buaya dengan 3 seri konsentrasi dan melihat rata-rata luas zona hambat terbesar yang selanjutnya dibuat sediaan gel. Variansi daun kemangi yaitu 0,5%, 1% dan 1,5% kemudian lidah buaya 5%. Gel yang dibuat dengan formula kombinasi ekstrak daun kemangi 1,5% dan lidah buaya 5% dengan gelling agent sodium alginate. Zat tambahan alkohol, akuades, gliserin dan metil paraben. Evaluasi gel meliputi uji pH, organoleptis, homogenitas, daya sebar, daya lekat dan iritasi kulit. Analisis data digunakan uji Anova satu arah dilanjutkan uji tukey dengan taraf kepercayaan 95%. Hasil menunjukkan kombinasi ekstrak daun kemangi 1,5% dengan lidah buaya 5% merupakan kombinasi dengan luas rata-rata zona hambat terbesar. Sediaan gel kombinasi ekstrak daun kemangi 1,5% dan lidah buaya 5% memiliki evaluasi gel yang memenuhi pesyaratan sifat fisik gel dan mampu menghambat bakteri Propionibacterium acnes dengan luas rata-rata zona hambat yaitu 2,52 mm.
Hubungan Pola Makan Dengan Kejadian Hipertensi Pada Lansia Di UPTD Panti Sosial Tresna Werdha Kecamatan Natar Lampung Selatan
Authors: Mustofa Festy Ladyani , Hasbie Neno Fitriyani , Roynaldo Muhammad Dwi 
Published: April 2022

ABSTRACTOne of the risk factors for hypertension is diet. Some of the risky food eating behaviors that cause hypertension are frequent eating salty foods, often eating sweet foods and often eating fatty foods. The condition of the risky food behavior in the elderly community increased its percentage from 2007 to 2013, only the behavior of eating sweet foods decreased 9.4%, while the eating behavior increased sharply by 1.7%. Purpose to see the relationship between diet and the incidence of hypertension in the elderly at the Tresna Werdha Social Home, Natar Lampung Selatan Subdistrict in 2020. The type of research used in this study was quantitative with a cross sectional design. The sample used in this study was the elderly at the UPTD Tresna Werdha Social Institution, Natar Lampung Selatan District in 2020. Data analysis used the Chi-Square Test. The results of the chi square test for the relationship between diet and the incidence of hypertension obtained a significance value / p-value of 0.000 with an odds ratio of 14.250. There is a relationship between diet and the incidence of hypertension in the elderly in the UPTD Tresna Werdha Social Institution, Natar Lampung Selatan Subdistrict in 2020. If someone has a bad diet, that person is at risk of developing hypertension 14,250 times higher than those who have a good diet Keywords: Hypertension, Diet, ElderlyABSTRAK Faktor risiko dari hipertensi salah satunya adalah pola makan. Beberapa perilaku makan-makanan yang berisiko yang menyebabkan hipertensi adalah sering makan makanan asin, sering makan makanan manis dan sering makan makanan berlemak. Kondisi perilaku makan makanan berisiko pada komunitas lansia terjadi peningkatan presentasenya dari tahun 2007 ke tahun 2013, hanya pada perilaku makan- makanan manis yang terjadi penurunan 9,4 %, sedangkan pada perilaku makan makanan asin meningkat tajam sebesar 1,7 %. Untuk mengetahui hubungan pola makan dengan kejadian hipertensi pada lansia di UPTD Panti Sosial Tresna Werdha Kecamatan Natar Lampung Selatan tahun 2020. Jenis penelitian yang digunakan dalam penelitian ini adalah kuenatittatif dengan desain cross sectional. Sampel yang digunakan pada penelitian ini adalah lansia di UPTD Panti Sosial Tresna Werdha Kecamatan Natar Lampung Selatan tahun 2020. Analisa data menggunakan Uji Chi-Square. Hasil uji chi square hubungan antara pola makan dengan kejadian hipertensi didapatkan nilai signifikansi/p-value sebesar 0,000 dengan nilai odd ratio sebesar 14,250. Terdapat hubungan pola makan dengan kejadian hipertensi pada lansia di UPTD Panti Sosial Tresna Werdha Kecamatan Natar Lampung Selatan Tahun 2020. Apabila seseorang memiliki pola makan yang buruk maka orang tersebut beresiko mengalami hipertensi 14,250 kali lebih tinggi dibandingkan dengan mereka yang memiliki pola makan yang baik Kata Kunci : Hipertensi, Pola Makan, Lansia
Reusable Extractant and Direct Catalytic Mediation of Water/Oil/Chlorodifluoromethane Nano-Emulsion in Natural Gas Condensate for Efficient Conversion of Chloride Impurities Into the Dicopper Chloride Trihydroxide Nanoparticles
Authors: Banan Khorshid Zohre , Doroodmand Mohammad Mahdi 
Published: April 2022

This research introduces an oil-in-water (O/W) nano-emulsion (oil-water-CHClF2) as the reusable extractant phase using liquid–liquid extraction methodology for the removal efficiency of Cl− and Hg(0) [between 90% and ∼100%, deepening on the nature of the natural gas condensate (NGC)] at a brief separation time (&lt;3.0 min). The achieved safety of the NGC using this nano-emulsion results in efficient reduction in the corrosion rate during testing iron-based fragments (vs. the untreated ones as controls) and increase in the NGC economic value. Another advantage of the synthesized nano-emulsion is its capability and catalytic mediating behavior to efficiently separate and synthesize highly pure dicopper chloride trihydroxide nanoparticles. The synthesized nanoparticles were characterized by different analytical methods such as Fourier transform infrared spectrometry, X-ray diffraction, X-ray photoelectron spectrometry, and direct visualization by some electron microscopies. Direct synthesis, fast synthetic time (&lt;3.0 min), high purity (&gt;99%), and scalability are the main advantages of this synthetic method. This nanoparticle is not only safe but also is efficiently applicable in different industries, especially as an eco-friendly agricultural pesticide for different plants and tress such as pistachio. Consequently, this method is accepted as direct, simple, low-cost, and scalable conversion of some upstream industries with the downstream ones. All these possibilities are attributed to the intermediate transport properties of the introduced O/W nano-emulsion. At this condition, this reagent plays role as a recycled motor for the NGC purification and conversion of these impurities into the safe and usable products. To the best of knowledge, this research is considered as the first report that shows application of this O/W medium for both chloride and mercury removal from the NGC and its direct use as top element in the synthesis of eco-friendly nanoparticles. This system is applicable in some parts of the fuel and oil centers of the “Middle East.”
Towards a Digital Twin of the Earth System: Geo-Soft-CoRe, a Geoscientific Software & Code Repository
Authors: DeFelipe Irene , Alcalde Juan , Baykiev Eldar , Bernal Isabel , Boonma Kittiphon , Carbonell Ramon , Flude Stephanie , Folch Arnau , Fullea Javier , García-Castellanos Daniel , Geyer Adelina , Giralt Santiago , Hernández Armand , Jiménez-Munt Ivone , Kumar Ajay , Llorens Maria-Gema , Martí Joan , Molina Cecilia , Olivar-Castaño Andrés , Parnell Andrew , Schimmel Martin , Torné Montserrat , Ventosa Sergi 
Published: April 2022

The immense advances in computer power achieved in the last decades have had a significant impact in Earth science, providing valuable research outputs that allow the simulation of complex natural processes and systems, and generating improved forecasts. The development and implementation of innovative geoscientific software is currently evolving towards a sustainable and efficient development by integrating models of different aspects of the Earth system. This will set the foundation for a future digital twin of the Earth. The codification and update of this software require great effort from research groups and therefore, it needs to be preserved for its reuse by future generations of geoscientists. Here, we report on Geo-Soft-CoRe, a Geoscientific Software &amp; Code Repository, hosted at the archive DIGITAL.CSIC. This is an open source, multidisciplinary and multiscale collection of software and code developed to analyze different aspects of the Earth system, encompassing tools to: 1) analyze climate variability; 2) assess hazards, and 3) characterize the structure and dynamics of the solid Earth. Due to the broad range of applications of these software packages, this collection is useful not only for basic research in Earth science, but also for applied research and educational purposes, reducing the gap between the geosciences and the society. By providing each software and code with a permanent identifier (DOI), we ensure its self-sustainability and accomplish the FAIR (Findable, Accessible, Interoperable and Reusable) principles. Therefore, we aim for a more transparent science, transferring knowledge in an easier way to the geoscience community, and encouraging an integrated use of computational infrastructure.Systematic Review Registration: https://digital.csic.es/handle/10261/193580.
General and Central Obesity Are Associated With Increased Severity of the VMS and Sexual Symptoms of Menopause Among Chinese Women: A Longitudinal Study
Authors: Tang Ruiyi , Fan Yubo , Luo Min , Zhang Duoduo , Xie Zhuolin , Huang Feiling , Wang Yuchen , Liu Gaifen , Wang Yaping , Lin Shouqing , Chen Rong 
Published: April 2022

BackgroundStrong evidence has linked overweight and obesity to increased risks of cardiovascular disease and all-cause mortality in Chinese populations. Menopause is considered associated with increased obesity and central body fat distribution. However, the correlation between obesity and menopausal symptoms has not been well studied.ObjectiveTo examine the associations between obesity or abdominal obesity and menopausal symptoms as women progressed from premenopausal to postmenopausal status.DesignThis study included 430 midlife Chinese women who had experienced natural menopause and were followed up for 10 years. Physical examinations and questionnaires should be completed annually. The questionnaires include the Menopause-Specific Quality of Life questionnaire, the Hospital Anxiety and Depression Scale, and other physical and behavioral factors.ResultsAmong women who were not obese (n=345) or not abdominal obese (n=372) at baseline, 5.8% and 31.7% became obese or abdominal obese at the recent follow-up visit, respectively. Women at the recent follow-up visit had an increased body mass index (BMI) by 0.14%, and the waist-to-hip ratio (WHR) increased by 5.2% compared with the data at baseline. In multivariate analysis, more frequent hot flashes, moderate/severe bothered vasomotor symptoms (VMS), mild bothered sexual functioning, and less anxiety symptoms were significantly associated with obesity. Increasing age, moderate/severe bothered VMS, and less anxiety symptoms were independently associated with abdominal obesity. Multivariable analysis also showed that less education level is independently associated with both obesity and abdominal obesity.ConclusionOur findings suggest that the proportion of obesity and abdominal obesity increased gradually during menopause. The increase of abdominal obesity is more rapidly than obesity in middle-aged women. Both obesity and abdominal obesity are related with severe or frequent VMS and anxiety symptoms in Chinese women. Although the proportion of obese women in China is lower than in western countries, the problem of abdominal obesity and related complications cannot be ignored.
Homologous Recombination Related Signatures Predict Prognosis and Immunotherapy Response in Metastatic Urothelial Carcinoma
Authors: Li Pan , Chen Chaohu , Li Jianpeng , Yang Li , Wang Yuhan , Dong Zhilong , Mi Jun , Zhang Yunxin , Wang Juan , Wang Hanzhang , Rodriguez Ronald , Tian Junqiang , Wang Zhiping 
Published: April 2022

Objective: This study used homologous recombination (HR) related signatures to develop a clinical prediction model for screening immune checkpoint inhibitors (ICIs) advantaged populations and identify hub genes in advanced metastatic urothelial carcinoma.Methods: The single-sample gene enrichment analysis and weighted gene co-expression network analysis were applied to identify modules associated with immune response and HR in IMvigor210 cohort samples. The principal component analysis was utilized to determine the differences in HR-related module gene signature scores across different tissue subtypes and clinical variables. Risk prediction models and nomograms were developed using differential gene expression analysis associated with HR scores, least absolute shrinkage and selection operator, and multivariate proportional hazards model regression. Additionally, hub genes were identified by analyzing the contribution of HR-related genes to principal components and overall survival analysis. Finally, clinical features from GSE133624, GSE13507, the TCGA, and other data sets were analyzed to validate the relationship between hub genes and tumor growth and mutation.Results: The HR score was significantly higher in the complete/partial response group than in the stable/progressive disease group. The majority of genes associated with HR were discovered to be involved in the cell cycle and others. Genomically unstable, high tumor level, and high immune level samples all exhibited significantly higher HR score than other sample categories, and higher HR scores were related to improved survival following ICIs treatment. The risk scores for AUNIP, SEPT, FAM72D, CAMKV, CXCL9, and FOXN4 were identified, and the training and verification groups had markedly different survival times. The risk score, tumor neoantigen burden, mismatch repair, and cell cycle regulation were discovered to be independent predictors of survival time following immunotherapy. Patients with a high level of expression of hub genes such as EME1, RAD51AP1, and RAD54L had a greater chance of surviving following immunotherapy. These genes are expressed at significantly higher levels in tumors, high-grade cancer, and invasive cancer than other categories, and are associated with TP53 and RB1 mutations.Conclusion: HR-related genes are upregulated in genomically unstable samples, the survival time of mUC patients after treatment with ICIs can be predicted using a normogram model based on HR signature.
Characterization of the Ferroptosis-Related Genes for Prognosis and Immune Infiltration in Low-Grade Glioma
Authors: Yan Xiuwei , Ji Hang , Liu Zhihui , Ma Shuai , Dong Jiawei , Jiang Xiaoyan , Hu Xueyan , Wang Fang , Zhao Hongtao , Jin Jiaqi , Zhang Jiheng , Wang Nan , Du Jianyang , Hu Shaoshan 
Published: April 2022

Background: Although ferroptosis has been validated to play a crucial role in some types of tumors, the influence of ferroptosis-related genes (FRGs) on the immune microenvironment in low-grade glioma (LGG) remains unclear. In this research, we screen the FRGs to assess the prognosis value and immune microenvironment in LGG, to provide reliable diagnosis and treatment evidence for the clinic.Methods: A total of 1,239 patients of LGG samples were selected for subsequent analyses from The Cancer Genome Atlas, Chinese Glioma Genome Atlas, and the Repository of Molecular Brain Neoplasia Data datasets. Univariate Cox regression analysis was used to screen for prognostic FRGs. Consensus clustering was utilized to determine ferroptosis subtypes of LGG patients. Next, the prognostic model was constructed based on differentially expressed FRGs and validation in the validating datasets. The immune microenvironment, biological pathway, and hypoxia score were explored by single-sample gene set enrichment analysis. The potential response of chemotherapy and immune checkpoint blockade therapy was also estimated. In addition, the correlation between the risk score and autophagy-related genes was examined by the Pearson correlation coefficient.Results: A total of three ferroptosis subtypes were identified by consensus clustering for prognostic FRGs which exhibited different outcomes, clinicopathological characteristics, and immune microenvironment. Afterward, a prognostic model that performed great predictive ability based on nine prognostic FRGs has been constructed and validated. Moreover, the prognostic model had the potential to screen the sensitivity to chemotherapy and immunotherapy in LGG patients. Finally, we also found that the prognostic model has a great connection to autophagy and hypoxia.Conclusion: We developed a ferroptosis-related prognostic model which strongly linked to diagnosis, treatment, prognosis, and recurrence of LGG. This study also reveals the connection between ferroptosis and tumor immune microenvironment.