bluuebunny/crossref_metadata_2025_split huggingface dataset:
The beginning and ending of a respiratory viral pandemic‐lessons from the Spanish flu
Authors: Brüssow Harald 
Published: March 2022

SummaryThe COVID‐19 pandemic goes into its third year and the world population is longing for an end to the pandemic. Computer simulations of the future development of the pandemic have wide error margins and predictions on the evolution of new viral variants of SARS‐CoV‐2 are uncertain. It is thus tempting to look into the development of historical viral respiratory pandemics for insight into the dynamic of pandemics. The Spanish flu pandemic of 1918 caused by the influenza virus H1N1 can here serve as a potential model case. Epidemiological observations on the shift of influenza mortality from very young and old subjects to high mortality in young adults delimitate the pandemic phase of the Spanish flu from 1918 to 1920. The identification and sequencing of the Spanish flu agent allowed following the H1N1 influenza virus after the acute pandemic phase. During the 1920s H1N1 influenza virus epidemics with substantial mortality were still observed. As late as 1951, H1N1 strains of high virulence evolved but remained geographically limited. Until 1957, the H1N1 virus evolved by accumulation of mutations (‘antigenic drift’) and some intratypic reassortment. H1N1 viruses were then replaced by the pandemic H2N2 influenza virus from 1957, which was in 1968 replaced by the pandemic H3N2 influenza virus; both viruses were descendants from the Spanish flu agent but showed the exchange of entire gene segments (‘antigenic shift’). In 1977, H1N1 reappeared from an unknown source but caused only mild disease. However, H1N1 achieved again circulation in the human population and is now together with the H3N2 influenza virus an agent of seasonal influenza winter epidemics.
Sexually dimorphic organization of open field behavior following moderate prenatal alcohol exposure
Authors: Osterlund Oltmanns Jenna R. , Schaeffer Ericka A. , Goncalves Garcia Monica , Donaldson Tia N. , Acosta Gabriela , Sanchez Lilliana M. , Davies Suzy , Savage Daniel D. , Wallace Douglas G. , Clark Benjamin J. 
Published: March 2022

AbstractBackgroundPrenatal alcohol exposure (PAE) can produce deficits in a wide range of cognitive functions but is especially detrimental to behaviors requiring accurate spatial information processing. In open field environments, spatial behavior is organized such that animals establish “home bases” marked by long stops focused around one location. Progressions away from the home base are circuitous and slow, while progressions directed toward the home base are non‐circuitous and fast. The impact of PAE on the organization of open field behavior has not been experimentally investigated.MethodsIn the present study, adult female and male rats with moderate PAE or saccharin exposure locomoted a circular high walled open field for 30 minutes under lighted conditions.ResultsThe findings indicate that PAE and sex influence the organization of open field behavior. Consistent with previous literature, PAE rats exhibited greater locomotion in the open field. Novel findings from the current study indicate that PAE and sex also impact open field measures specific to spatial orientation. While all rats established a home base on the periphery of the open field, PAE rats, particularly males, exhibited significantly less clustered home base stopping with smaller changes in heading between stops. PAE also impaired progression measures specific to distance estimation, while sex alone impacted progression measures specific to direction estimation.ConclusionsThese findings support the conclusion that adult male rats have an increased susceptibility to the effects of PAE on the organization of open field behavior.
Longitudinal accounting comparability and bond credit spreads: Evidence from China
Authors: Cao Shijiao , Wang Jianqiong 
Published: March 2022

AbstractThis paper proposes a procedure to measure firms’ longitudinal accounting comparability and investigates whether it affects bond risk premiums. The results provide robust evidence that bonds of firms with more longitudinally comparable accounting information have lower credit spreads. This effect is stronger when the firms’ financial performance is poor and for bonds with speculative credit ratings. Results also reveal that firms with less longitudinally comparable accounting information are more informationally asymmetric and do have a higher expected default probability. Finally, the effects of the longitudinal and the cross‐sectional comparability in reducing bond credit spreads are incremental to each other.
Review article: Lynch Syndrome—a mechanistic and clinical management update
Authors: Curtius Kit , Gupta Samir , Boland C. Richard 
Published: March 2022

SummaryBackgroundLynch syndrome (LS) is an autosomal dominant familial condition caused by a pathogenic variant (PV) in a DNA mismatch repair gene, which then predisposes carriers to various cancers.AimTo review the pathogenesis, clinical presentation, differential diagnosis and clinical strategies for detection and management of LS.MethodsA narrative review synthesising knowledge from published literature, as well as current National Comprehensive Cancer Network guidelines for management of LS was conducted.ResultsLS tumours are characterised by unique pathogenesis, ultimately resulting in hypermutation, microsatellite instability and high immunogenicity that has significant implications for cancer risk, clinical presentation, treatment and surveillance. LS is one of the most common hereditary causes of cancer, and about 1 in 279 individuals carry a PV in an LS gene that predisposes to associated cancers. Individuals with LS have increased risks for colorectal, endometrial and other cancers, with significant variation in lifetime risk by LS‐associated gene.ConclusionsAs genetic testing becomes more widespread, the number of individuals identified with LS is expected to increase in the population. Understanding the pathogenesis of LS informs current strategies for detection and clinical management, and also guides future areas for clinical innovation. Unravelling the mechanisms by which these tumours evolve may help to more precisely tailor management by the gene involved.
Editorial: opposite effects of genetic polymorphisms known to induce NAFLD on hepatic and cardiovascular outcomes in Chinese population—authors' reply
Authors: Xia Mingfeng , Gao Xin 
Published: March 2022

LINKED CONTENTThis article is linked to Xia et al papers. To view these articles, visit https://doi.org/10.1111/apt.16772 and https://doi.org/10.1111/apt.16818
Automatic market research of mobile health apps for the self‐management of allergic rhinitis
Authors: Antó Aram , Sousa‐Pinto Bernardo , Czarlewski Wienczyslawa , Pfaar Oliver , Bosnic‐Anticevich Sinthia , Klimek Ludger , Matricardi Paolo , Tripodi Salvatore , Fonseca Joao A. , Antó Josep M. , Bousquet Jean 
Published: March 2022

AbstractBackgroundOnly a small number of apps addressing allergic rhinitis (AR) patients have been evaluated. This makes their selection difficult. We aimed to introduce a new approach to market research for AR apps, based on the automatic screening of Apple App and Google Play stores.MethodsA JavaScript programme was devised for automatic app screening, and applied in a market assessment of AR self‐management apps. We searched the Google Play and Apple App stores of three countries (USA, UK and Australia) with the following search terms: "hay fever", "hayfever", "asthma", "rhinitis", "allergic rhinitis". Apps were eligible if symptoms were evaluated. Results obtained with the automatic programme were compared to those of a blinded manual search. As an example, we used the search to assess apps that can be used to design a combined medication score for AR.ResultsThe automatic search programme identified 39 potentially eligible apps out of a total of 1593 retrieved apps. Each of the 39 apps was individually checked, with 20 being classified as relevant. The manual search identified 19 relevant apps (out of 6750 screened apps). Combining both methods, a total of 21 relevant apps were identified, pointing to a sensitivity of 95% and a specificity of 99% for the automatic method. Among these 21 apps, only two could be used for the combined symptom‐medication score for AR.ConclusionsThe programmed algorithm presented herein is able to continuously retrieve all relevant AR apps in the Apple App and Google Play stores, with high sensitivity and specificity. This approach has the potential to unveil the gaps and unmet needs of the apps developed so far.
A rural ecosystem of recovery: Lessons from substance users' experiences of accessing services in Western Australia's South West
Authors: Cuesta‐Briand Beatriz , Taran Michael , Coleman Mathew 
Published: March 2022

AbstractIntroductionSubstance use is a public health issue with a greater burden in rural areas. Barriers to accessing services are exacerbated for rural substance users, with confidentiality concerns, longer travel distances, workforce issues and limited availability of services. This paper presents results from a study exploring substance users' experiences of accessing services in Western Australia's South West.MethodsThis qualitative study was informed by phenomenology, and drew from social determinants and socio‐ecological theories. Data were collected through 22 semi‐structured telephone interviews with current and past substance users residing in the South West. Interviews were audio‐recorded and transcripts were subjected to thematic analysis.ResultsTwo themes were identified: readiness to engage as a three‐way street; and building an ecosystem of recovery networks. Effective engagement with services required multi‐level readiness. Individual readiness was strongly influenced by the social environment, while service readiness required trustworthiness and responsiveness. A number of local access barriers were identified that hindered broader system readiness. Participants experienced recovery as on‐going and require an ecosystem of support with peer support at the centre and a network of healthy relationships established through meaningful connections.Discussion and ConclusionsAn effective ecosystem of support for alcohol and other drugs users in the South West should include expanded access to health, community and welfare services, with an emphasis on peer‐led support programs, and strong cross‐sector collaboration to mitigate the access barriers operating at the broader community level. Lessons from our study can inform the development of rural ecosystems of support for alcohol and other drugs users.
Captive breeding of odonate larvae: Effects of type of water, handling, and sex
Authors: Palacino‐Rodríguez Fredy , Cordero‐Rivera Adolfo , Palacino Diego Andrés , Penagos Andrea Carolina 
Published: March 2022

AbstractBasic information on life histories, ecology, and behaviour for aquatic stages in many species of insects is difficult to obtain in the field. Here, a method to breed and monitor individual Odonata larvae in captivity is proposed. In total, 3788 individuals of six Odonata species – Rhionaeschna marchali (Rambur), Erythrodiplax abjecta (Rambur), Sympetrum gilvum (Selys), Ischnura chingaza Realpe, Ischnura cruzi De Marmels, and Mesamphiagrion laterale (Selys) – were reared individually in water‐filled plastic containers, whose size was increased to fit larval growth, at ambient temperature (12–34 °C, 12 h light per day, ca. 300 lux, and ad libitum food). We tested the effects of water type (habitat water, dechlorinated tap water, and drinking water), handling method, and sex on larval developmental time and number of instars. The number of instars was calculated as the mean number of moults for the individuals that successfully emerged as adults. Life cycle length was calculated by averaging the days over individuals that completed their development until emergence. The probability of achieving the adult stage was not significantly affected by the type of water, sex, or handling method. On the other hand, the number of instars was affected by species identity, and type of water, with fewer instars in water from the natural habitat, but not affected by sex or handling method. The duration of the life cycle was bimodal in most species, and was affected by type of water, but in an idiosyncratic, species‐specific way. The methodology proposed here allows monitoring and breeding large numbers of odonate larvae.
Demonstration of local adaptation in maize landraces by reciprocal transplantation
Authors: Janzen Garrett M. , Aguilar‐Rangel María Rocío , Cíntora‐Martínez Carolina , Blöcher‐Juárez Karla Azucena , González‐Segovia Eric , Studer Anthony J. , Runcie Daniel E. , Flint‐Garcia Sherry A. , Rellán‐Álvarez Rubén , Sawers Ruairidh J. H. , Hufford Matthew B. 
Published: March 2022

AbstractPopulations are locally adapted when they exhibit higher fitness than foreign populations in their native habitat. Maize landrace adaptations to highland and lowland conditions are of interest to researchers and breeders. To determine the prevalence and strength of local adaptation in maize landraces, we performed a reciprocal transplant experiment across an elevational gradient in Mexico. We grew 120 landraces, grouped into four populations (Mexican Highland, Mexican Lowland, South American Highland, South American Lowland), in Mexican highland and lowland common gardens and collected phenotypes relevant to fitness and known highland‐adaptive traits such as anthocyanin pigmentation and macrohair density. 67k DArTseq markers were generated from field specimens to allow comparisons between phenotypic patterns and population genetic structure. We found phenotypic patterns consistent with local adaptation, though these patterns differ between the Mexican and South American populations. Quantitative trait differentiation (QST) was greater than neutral allele frequency differentiation (FST) for many traits, signaling directional selection between pairs of populations. All populations exhibited higher fitness metric values when grown at their native elevation, and Mexican landraces had higher fitness than South American landraces when grown in these Mexican sites. As environmental distance between landraces’ native collection sites and common garden sites increased, fitness values dropped, suggesting landraces are adapted to environmental conditions at their natal sites. Correlations between fitness and anthocyanin pigmentation and macrohair traits were stronger in the highland site than the lowland site, supporting their status as highland‐adaptive. These results give substance to the long‐held presumption of local adaptation of New World maize landraces to elevation and other environmental variables across North and South America.
Fed_ADBN: An efficient intrusion detection framework based on client selection in AMI network
Authors: Xia Zhuoqun , Chen Yaling , Yin Bo , Liang Haolan , Zhou Hongmei , Gu Ke , Yu Fei 
Published: March 2022

AbstractData transmission between smart meters and data center is facing network security threats in advanced metering infrastructure of smart grid. The traditional solution is to move the data to the data center to build a centralized attack detection model, or divide the collected data into several independent and identically distributed datasets to build a distributed attack detection model. However, the long‐distance transmission and the centralized storage of data not only increase the communication overhead and time overhead, but also increase the risk of being attacked, causing privacy disclosure during the process of building the model. In this paper, we propose an efficient intrusion detection framework Fed_ADBN based on federated attention deep belief network and client selection. Clients cooperate with the data center to jointly build a horizontal federated learning framework. Under the premise of protecting data security by keeping data on the clients, we design a client selection algorithm based on client computing power, communication quality and security risks, which can improve the operating efficiency of federated learning. We also deploy a deep belief neural network with attention mechanism in each client to accurately detect possible network attacks in AMI network in real time. Experimental results show that compared with state‐of‐the‐art methods, the proposed framework can not only maintain good detection accuracy but also protect privacy.
Atrophic gastritis in Helicobacter pylori‐infected children
Authors: Hsieh Hsuan , Yang Hsiao‐Bai , Sheu Bor‐Shyang , Yang Yao‐Jong 
Published: March 2022

AbstractBackgroundHelicobacter pylori infection is the leading cause of peptic ulcer and chronic gastritis and may initiate gastric carcinogenesis following the Correa cascade. Another lineage of metaplasia, spasmolytic peptide‐expressing metaplasia (SPEM) has recently been found to be an alternative precursor to gastric cancer. To date, few reports have investigated gastric precancerous lesions among children with H. pylori infection. This study aimed to evaluate the histopathological pattern of H. pylori atrophic gastritis in children and the extent of precancerous lesions.Materials and MethodsThis study enrolled pediatric patients with H. pylori infection from 1998 to 2019. During esophagogastroduodenoscopy examinations, biopsy fragments were collected from the gastric antrum and corpus for rapid urease test, culture, and histology evaluation. The presence and degree of chronic inflammation, activity of gastritis, H. pylori density, atrophy, and intestinal metaplasia (IM) were assessed according to the modified Updated Sydney System. Trefoil factor 2 (TFF2) immunohistochemistry was also performed to assess SPEM in the gastric tissues collected from each case using rabbit anti‐human TFF2 antibodies.ResultsA total of 92 children with H. pylori infection and adequate gastric mucosa biopsies were enrolled. Esophagogastroduodenoscopy showed that 39 (42.4%) had duodenal ulcers, 11 (12.0%) had gastric ulcers, 41 (44.6%) had gastritis, and 1 (1.1%) had negative findings. Mild‐to‐moderate IM was identified in 4 patients (4.3%). SPEM was found in 8 patients (8.7%) with a significantly higher incidence among female patients (15.8% vs. 8.7%, p = .031). Gastric glandular atrophy presented in 28 patients (30.4%), and high‐grade atrophy was more common in female patients (3.2% vs. 1.9%, p = .031).ConclusionsThe prevalence rates of atrophic gastritis in the children with H. pylori infection were 30.4% for gastric glandular atrophy, 4.3% for IM and 8.7% for SPEM. SPEM and high‐grade atrophy were more common in female patients.
Expression profiles of cdca9 related to ovarian development in loach (Misgurnus anguillicaudatus)
Authors: Huang Yuwei , Zhang Yunbang , Gao Jian , Cao Xiaojuan 
Published: March 2022

AbstractThe function of borealin proteins has been widely reported in the cell division of animals. Nonetheless, there is little research about their only known paralogue (cell division cycle associated 9, cdca9). In this study, cdca9 was investigated in loach (Misgurnus anguillicaudatus) for the first time. cdca9 was highly expressed in the embryo before the gastrula stage, and it was predominantly expressed in the ovary, especially in the oocytes of stage II. In conclusion, this study reveals a potential function of cdca9 in the early embryogenesis and ovarian development of fish.
Prediction of mass‐based process designing parameters of amla fruit using different modeling techniques
Authors: Tomar Mahipal Singh , Pradhan Rama Chandra 
Published: March 2022

AbstractThe machine designing parameters such as size, volume, criteria projected area are important for quality evaluation at the time of packaging, grading, and sorting of fruits. All these designing parameters also depend on mass of the fruit sample. So, the correlation between mass and designing parameters could be useful for automation of the process industry. The research was inducted to predict the dimension, projected area, and volume of fruit as a function of fruit mass. Prediction modeling was done using different models, that is, mathematical model (MM), artificial neural network (ANN), and support vector regression (SVR). The mathematical model (linear, quadratic, and power) showed better prediction results than SVR modeling. In addition, the best results were achieved by neural network‐based prediction modeling. It showed the highest correlation coefficient of .884, .986, .992, .999 and the lowest error of 0.570, 0.241, 8.080, 0.059 for height, diameter, projected area, and volume, respectively. It is observed that the physical properties of fruit can be predicted using ANN‐based modeling which could be useful in automation and efficient designing of post‐harvest equipment.Practical ApplicationThe machine designing parameters are the essential and fundamental parameters for designing of grading, sorting, packaging, and handling equipments of various horticultural products including amla. Fruits and vegetables are non‐uniform in size and shape. So, minor changes in shape and size of fruits could decrease the efficiency of various processes and its equipment. The design parameters of fruits and vegetables are dependent on the mass of samples. So, accurate knowledge of mass and design parameters could help in designing the automatic grading system. Different models can be used to predict various designing parameter of amla or similar fruits. By using various models, fruit can be separated more accurately based on minor changes in shape and size rather than its mass. The ANN‐based prediction will be beneficial for the automation of the fruits grading system at an industrial scale.
Detection of frequent neutrophil misclassification by the ProCyte Dx in sick dogs and how to avoid it
Authors: Bergstrand E. , Tvedten H. W. , Lilliehöök I. 
Published: March 2022

ObjectivesA common and severe error in identifying neutrophils in feline blood samples by the IDEXX ProCyte Dx haematology analyser (ProCyte) has been reported. The hypothesis was that the same or similar error would be identified during analysis of canine blood samples and that white blood cell dot plot evaluation would be critical to detect and avoid erroneous results.Materials and MethodsEighty‐six canine blood samples collected for clinical diagnosis of hospital patients were evaluated. Differential leukocyte counts were determined by the ProCyte Dx, ADVIA 2120 and manual methods. ProCyte neutrophil percentage results were considered unacceptable if the result was 15% different than percentage results from both ADVIA 2120 and manual counts. ProCyte WBC dot plots and instrument flags were evaluated for correctness.ResultsThe ProCyte neutrophil counts were unacceptably lower than the ADVIA 2120 and manual neutrophil counts in 13 samples (15% of 86 samples). Neutrophils misclassified by the instrument were erroneously classified as monocytes and/or lymphocytes. All these samples were from patients with systemic inflammation. The error could be eliminated by rejecting results from samples with incorrect separation of cell clusters in the ProCyte WBC dot plots.Clinical SignificanceThe ProCyte neutrophil count error with canine blood samples is common, severe and might affect clinical decisions. Operators of the instrument must evaluate white blood cell dot plots for correctness to avoid the error.