bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Diagnostic Accuracy of Alpha-Fodrin Antibody in Iranian Patients with Sjogren's Disease
Authors: Rostamian Alireza , Baradaran Azar , Mottaghi Peyman , Salesi Mansour , Karimifar Mansour , Mansouri Vahid 
Published: August 2022

Background:
Sjogren's syndrome, as a chronic autoimmune disease, involves in lymphocytic infiltration in the exocrine glands. As the result of exocrine glands disruption, the clinical hallmark of this disease including dryness of mouth and eyes along with fatigue and joint pain occur. However, heterogeneity of clinical presentations among newly diagnosed adult patients with Sjogren's syndrome leads to difficulty in its diagnosis. One of the diagnostic criteria for Sjogren's syndrome is the presence of autoantibodies in patient serum. One of the novel biomarkers suggested for diagnosis of Sjogren is alpha-fodrin antibody. In this study, we aimed to evaluate the diagnostic power of anti-α-fodrin antibody among the Iranian population for the first time.

Materials and Methods:
We recruited 82 individuals in this study. Alpha-fodrin were measured in case and control with Elisa kit as 16.71 (9.84) and 18.44 (11.54).

Results:
There was no any significant difference between two groups regarding alpha-fodrin level (P = 0.35). Then we applied the receiver operating characteristic (ROC) curve analysis to determine the predictive value of alpha-fodrin for diagnosing Sjogren's disease. The area under curve of the ROC curve was calculated as 0.5453. Also, there were significant association between age and alpha-fodrin antibody.

Conclusions:
Alpha-fodrin test did not have acceptable predictive power for predicting Sjogren's disease; however, it could be associated with disease progression.
Outcomes of laparoscopic appendectomy during the level 3 alert of the coronavirus disease 2019 pandemic in Taiwan
Authors: Tsou Hui-Ju , Huang Shou-Sen , Tsai Chung-Hsin , Cheng Shih-Ping , Chu Tun-Pang 
Published: August 2022

Background:
Emerging studies have reported an increased proportion of complicated cases of acute appendicitis and increased prehospital delay during the coronavirus disease 2019 (COVID-19) pandemic. We wondered whether there was a difference in the perioperative outcomes of laparoscopic appendectomy during the 69-day level 3 alert in our community.

Materials and Methods:
Adult patients who underwent laparoscopic appendectomy for acute appendicitis between May 19 and July 26, during the years of 2019, 2020, and 2021 at our institution, were included. Patient demographics, clinical presentation, interval from emergency department (ED) arrival to operation, operation duration, hospital stay, and postoperative complications were analyzed using SPSS Statistics. The Kruskal–Wallis and Pearson Chi-square tests were used for the analysis of numerical and nominal variables, respectively.

Results:
A total of 94, 102, and 63 cases were included during the corresponding periods in 2019, 2020, and 2021, respectively. Patient age, sex, symptom duration at presentation, percentage of leukocytosis, bacteremia, complicated appendicitis, and white blood cell count showed no group differences. The interval between ED arrival and surgery was not significantly different (P = 0.753). There were no significant differences in the operation duration (P = 0.094), estimated blood loss (P = 0.273), or proportion of drain insertion (P = 0.626). The length of hospital stay (P = 0.681), incidence of postoperative complications (P = 0.894), and postoperative complications according to the Clavien–Dindo classification (P = 0.241) were not significantly different among the groups.

Conclusion:
Adult patients undergoing laparoscopic appendectomy at our institution during the level 3 alert of the COVID-19 pandemic had no statistically significant differences in perioperative outcomes, including operation time, estimated blood loss, hospital stay, and complication rates.
Is perinatal asphyxia associated with an increase in serum bilirubin in neonates? A case-control study
Authors: Rai Seema , Sood Mangla , Kaur Amarpreet 
Published: August 2022

Objective:
Perinatal asphyxia affects different organs of body depending upon the severity of hypoxemia and ischemia. This study was carried out to evaluate severity of hyperbilirubinemia in relation to severity of asphyxia.

Study Design:
A case-control study.

Methodology:
Asphyxiated newborns with Apgar score ≤7 at 1 min. and categorized as severe birth asphyxia according to the WHO classification of diseases (ICD10) were matched with controls without birth asphyxia. All babies were examined twice daily for dermal icterus until start of phototherapy. Babies with congenital heart disease, sepsis, cephalohematoma, blood group incompatibility were excluded. Arterial blood gas analysis was done along with serial TSB measurement as per standard guidelines.

Results:
50 cases and 50 matched controls were enrolled. The average birth weight and gestation in cases was 2427 ± 30.05 g and 35.9 ± 2.5 weeks and among control it was 2633 ± 378.62 g and 37.76 ± 0.116 weeks. Among cases, onset of jaundice was 56.64 ± 20.43 h compared to 63.36 ± 23 h in control group. In the cases, the average pH was 7.31 ± 0.06, CO2 was 41.52 ± 84, O2 was 94.98 ± 14.83, and HCO3 was 18.56 ± 2.04. The rise and peak of serum bilirubin differed between the case and control groups; in the cases, the peak occurred at the 22nd h of life, then plateaued from the 40th to the 78th hour of life, and ultimately fell at the 96th hour of life. In comparison, the rise and peak of serum bilirubin occurred comparatively late in the control group. The rise and peak in the control group occurred at the 80th and 96th h of life, respectively. The multiple linear regression analysis showed CRP, Apgar at 5 min. below 7 and male gender significantly affects the rise of serum bilirubin (P < 0.05).

Conclusion:
The peak serum bilirubin in asphyxiated newborns occurs earlier, and plateau for longer duration compared to normal newborns. Low Apgar at 5 min. has significant correlation to earlier rise of bilirubin.
Facilitators and barriers in implementation of mass drug administration for lymphatic filariasis elimination in India
Authors: Sinha Abhinav , Mohapatra Sumegha , Pati Sanghamitra , Sahoo Prakash Kumar 
Published: August 2022

Introduction:
Lymphatic filariasis (LF) is a debilitating and disabling parasitic disease of immense public health concern in India with more than 650 million people at risk. Mass drug administration (MDA) is the recommended preventive chemotherapy strategy to eliminate LF. But, its coverage and compliance has been a mixed success. There is an urgent need of evidence to strengthen the program further, which can be done by exploring and understanding implementer as well as beneficiary perspectives.

Objective:
To systematically review the facilitators and barriers experienced during the coverage and compliance of MDA for LF elimination in India from both beneficiary and provider’s (health system) perspective. Methods and Analysis: We will search at Medline database through PubMed and Embase, along with ProQuest and Google Scholar to retrieve literature. Original qualitative observational studies exploring challenges and enablers in MDA program will be screened by two independent reviewers systematically based on title and abstract followed by full text. The risk of bias will be assessed through critical appraisal skills program checklist for each included article. Data will be extracted in a pre-designed proforma with study characteristics, demographic features, and texts and quotes of qualitative data. Data will be analyzed through thematic analysis and motivation-opportunity-ability-behavior framework using MAXQDA software.

Ethics and Dissemination:
This is a literature-based review with minimal privacy concerns. The findings of this study will be published in a peer-reviewed journal and disseminated through policy brief to program implementers.
Breast cancer knowledge and screening behaviors of female teachers
Authors: Alduraibi Sharifa K. 
Published: August 2022

Background:
Breast cancer is the second commonest cause of cancer-related deaths in Saudi Arabia. However, several women bypass early discovery and management possibilities.

Methods:
This cross-sectional study was conducted in the governmental secondary girls’ schools in Buraydah city, Saudi Arabia, during the period from August 2019 to January 2020. The data were collected using a valid pretested structured self-administered questionnaire.

Results:
The study included 316 female teachers. The total breast cancer knowledge score was abnormally distributed, as evidenced by significant Shapiro-Wilk test, P < 0.001. The mean ± SD score was 10.66 ± 3.73 (maximum possible score: 15) and the median (IQR) was 11 (8–13). Less than half (42.7%) of the teachers reported performing breast self-examination (BSE (while only 9.5% went to a clinic for clinical breast examination. BSE was performed on monthly basis by only 14.8% of those practiced it. Ignorance of the examination and fear to discover a tumor were mentioned by 24.9% for each as a reason for not performing BSE, whereas 42.5% of those who did not practice it had no definite reason. Mammogram was ever practiced by 22.5% of the female teachers. Older teachers (40–50) reported higher rates of performing mammogram compared to those aged <40, P = 0.012. Also, teachers who had friends with breast cancer were practiced mammogram at higher rate than their counterparts, P = 0.025.

Conclusion:
The breast cancer knowledge is overall insufficient regarding risk factors and clinical presentation. Improving knowledge regarding risk factors, presentation, and screening tools as BSE and mammogram through educational programs is highly recommended.
Postural deviation in pregnancy
Authors: Sarkar Pradip Kumar , Singh Paramvir , Dhillon Mandeep S. , Bhattacharya Sudip , Singh Amarjeet 
Published: August 2022

Objective:
The purpose of this study was to evaluate the effect of physiotherapeutic intervention to improve the deviated balance of pregnant women.

Method:
A total of 174 subjects were included in the study out of which 62 had postural deviation. They were divided into three groups, two intervention groups and one control group. The target population consisted of women in the antenatal stage, randomly selected from Obstetrics and Gynecology OPD, PGIMER, Chandigarh. The study was conducted over a period of 3 years (2014–2017). They were advised exercises, postural correction, regular walking, and hot water fomentation. Six follow-ups were taken into consideration throughout the pregnancy and postnatal stage.

Result:
The impact of the intervention package on both ante-natal and postnatal women with balance problems showed significant improvement.

Conclusion:
Postural deviations, pain, heaviness in the lower limb, incontinence, breathlessness, etc., are common complaints during and after pregnancy. The problem starts early in pregnancy and increased over time and may persist throughout life if treatment does not start early in the pregnancy. This intervention can be practiced in primary care setting after giving proper training to the health care workers by experienced physiotherapists.
Safer motherhood - birth preparedness and complication readiness assessment among pregnant women residing in urban slums of Marathwada region
Authors: Kadarkar Kalpak Shirish , Dhok Rajeshree S. 
Published: August 2022

Background:
Birth Preparedness and Complication Readiness (BPACR) is the intervention for planning of normal birth and anticipating the actions needed in case of complications. It is a comprehensive strategy to improve the use of skilled providers at birth, the key measure to reduce maternal mortality.

Objectives:
To assess the status of BPACR and associated sociodemographic factors among pregnant women in community.

Materials and Methods:
A community-based descriptive longitudinal study undertaken at urban slums among 156 pregnant women with >28 weeks of gestation. They were interviewed for BPACR components.

Results:
BPACR index was observed to be lower 48.3%. About 88% were aware about any one danger signs of pregnancy. Nearly, 77% of women availed antenatal care service in first trimester. About 85% women identified skilled birth attendant and mode of transport for delivery, 66% women saved money for delivery. Most common danger sign noted was abdominal pain (65.38%). Mother’s education, occupation, parity, and socioeconomic condition were significantly associated with three out of four components of BPACR.

Conclusion:
Low level of BPACR index was attributed to low level of awareness regarding government sponsored schemes and danger signs of pregnancy. This highlights need of more efforts in services provided by health care providers and workers. There is need of intense Information, Education and Communication activity focused on pregnant women and their family members.
Determinants of wasting among under-five children in Ethiopia
Authors: Gebremeskel Menaseb Gebrehaweria , Tirore Lire Lemma , Derilo Habtamu Tamrat 
Published: August 2022

Background:
In Ethiopia, wasting is still a serious public health problem in under-5 children regardless of the efforts done within the country. Although studies have been conducted in Ethiopia, multilevel analysis has rarely been used to identify the factors associated with wasting among children. Therefore, this study aimed to identify the factors of wasting among under-5 children in Ethiopia using multilevel ordinal logistic regression analysis.

Methods:
The data were obtained from the 2016 Ethiopia Demographic and Health Survey, conducted from January to June 2016. A sample of 8,919 children under-5 years was included. Data were analyzed using STATA version 14. A multilevel logistic regression model was fitted and an adjusted odds ratio (AOR) with a 95% confidence interval (CI) was obtained.

Results:
The prevalence of wasting among children under-5 years was 10.1% (901), of which 8.1% (632) had moderate wasting and 3.0% (269) had severe wasting. Children aged 36–47 months (AOR = 0.5; 95% CI: 0.4, 0.63), 48–59 (AOR = 0.5; 95% CI: 0.4–0.63), girls (AOR = 0.75; 95% CI: 0.65, 0.87), smaller-than-average birth weight (AOR = 1.94; 95% CI: 1.44, 2.61), very small birth weight (AOR = 1.75; 95% CI: 1.34, 2.30) were the individual-level factors associated with wasting, whereas husband’s educational status (AOR = 0.37; 95% CI: 0.29, 0.69) was the household-level factor. Somalia (AOR = 1.72; 95% CI: 1.08, 2.74), Sothern Nations Nationalities and People (SNNP) (AOR = 0.39; 95% CI: 0.24, 0.64), and Addis Ababa (AOR = 0.43; 95% CI: 0.21, 0.88) regions were the community-level factors associated with child wasting.

Conclusion:
This study shows that wasting among children under-5 years is affected by individual, household, and community-level factors. Interventions should be strengthened to give attention to the child’s early age, male sex, low birth weight, and husband’s educational status. In addition, interventions should target the regions identified to have a high risk of wasting.
Journal of family medicine and primary care- A five year bibliometric analysis from 2016 to 2020
Authors: Mohan Sumit , Thakur Jyoti , Mohan Chander , Agarwal Sakshi , Tirkey Richa 
Published: August 2022

Aim:
To conduct a five-year bibliometric analysis of the Journal of Family Medicine and Primary Care (J Family Med Prim Care) between 2016 and 2020.

Setting and Design:
This retrospective secondary data analysis was conducted in the Department of Conservative, Endodontics and Aesthetic Dentistry, Dental Institute, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand and Rohilkhand Medical College and Hospital, Bareilly, UP.

Material and Methods:
The data of publications including research articles, review and case reports excluding editorials and letters to the editor, commentaries and invited articles published in the J Family Med Prim Care between 2016 and 2020 were downloaded from the journal website and analysed in terms of the bibliometric parameters.

Results:
The results revealed that the journal gave equal weightage to all types of articles. The total number of articles published between 2016 and 2020 was 2,426 out of which 1,666 articles were published from India and the remaining from other parts of the world. In India, the state of Delhi had the maximum publications while speciality Preventive and Social Medicine (22.42%) and General Medicine (23.12%) had the maximum articles. Moreover, between 2016 and 2020, J Family Med Prim Care had 2,132 citations of published articles and had 65 publications in 2020 about the Corona Virus Disease (COVID-19) pandemic.

Conclusion:
The issue numbers per year for J Family Med Prim Care has gradually increased over time. The publication is open for all fields of medical, dental sciences and allied sciences.
A cross-sectional study on stigma and discrimination confronted by HIV positive patients in the economic capital of India
Authors: Sahu Ajaykumar C. , Akhade Kiran S. 
Published: August 2022

Context:
HIV/AIDS is a serious public health, economic and social problem. Stigma is a common human reaction to disease and discrimination follows stigma. Stigma and discrimination act as impediments to uptake of HIV testing, treatment, care and adherence to treatment.

Aim:
The aim of this study was to estimate the prevalence of the stigma and discrimination faced by HIV positive patients receiving antiretroviral therapy (ART). Settings and Design: A cross-sectional, observational study conducted at ART center of a tertiary care hospital in an urban area.

Methods and Material:
Participants were selected by simple random sampling among HIV positive patients. A predesigned, pretested and self-administered, semi-structured questionnaire in local language was used to assess stigma and discrimination.

Statistical Analysis Used:
The data were entered in Microsoft Excel and analyzed with SPSS version 20 statistical software. Simple proportions, mean, standard deviation, median, range and inter-quartile range were calculated.

Results:
Of 336 participants, 170 were male, whereas 166 were females. The mean age was 36.42 years. The total mean scores for Berger’s HIV stigma scale experienced was 122.82, whereas for individual subscale Personalized stigma, Negative self-image, public attitudes and disclosure of HIV status were 38.31, 27.46, 33.09 and 23.97, respectively. The maximum participants expressed the stigma regarding disclosure concerns (58.63%) followed by negative self-image stigma (43.45%).

Conclusions:
Stigma hurdles the delivery of effective medical social care. People Living with HIV and AIDS (PLWHA) need to have greater involvement in their care, support and treatment. Support groups of PLWHA need to be established so that stigma and discrimination at various levels can be challenged collectively.
Working hours impact on the sleep quality and oral health status among migrant construction workers in Chennai
Authors: Suresh Sushanthi , Doraikannan Srisakthi , Jayakumar N D , Indiran Meignana Arumugham , Kesavan R 
Published: August 2022

Background:
Nowadays, a shift in our lifestyle which espouses long working hours and low sleep quality can have a direct impact on the general health and oral health status. Sleep deprivation results from intense long working hours.

Aim:
To recognize the impact of long working hours, on sleep and oral health assessments of migrant construction workers.

Materials and Methods:
This is a cross-sectional study conducted among migrant construction workers working in Chennai comprised of 1,521 participants. The sleep quality was assessed using the Insomnia Severity Scale-7 and the working hours was found using the Google forms and their oral health status was assessed using the Oral hygiene index- Simplified (OHIS-S) and the Decayed Missing and Filled teeth (DMFT) index. The data were analysed using IBM SPSS Statistical Software version 23.0. Statistical tests like the Chi-square association and one-way Analysis of variance (ANOVA) (normally distributed) were used for the analysis of three group comparisons.

Results:
From the study results, most of the participants were between 25 and 35 years, smokers, had negligence on oral health and had poor sleep quality due to their long working hours. On the association between the working hours per week and OHIS, DMFT and Insomnia Severity Scale total score, a statistically significant relationship was found using the one-way ANOVA.

Conclusion:
The results from our study brought neglected oral health care of the construction workers into the limelight which will help us in our future efforts to improve the oral health of the construction workers.
Adherence to healthy behavioral practices promotes COVID 19 preventive behavior among chronic disease patients
Authors: Rustagi Neeti , Choudhary Yachana , Kumar Nitesh , Shafi Shazia , Saurabh Suman , Thirunavukkarasu Prasanna , Raghav Pankaja 
Published: August 2022

Background:
The coronavirus disease-19 (COVID-19) pandemic has led to unprecedented morbidity and mortality across the world. Chronic disease patients of urban poor neighbourhoods are one of the most vulnerable population subgroups as the number of cases and deaths increase exponentially in India. The study aims to explore the factors associated with desirable health behaviours among chronic disease patients availing care from a primary health facility and examine their association with the COVID-19 preventive behaviour.

Material and Methods:
A cross-sectional study was conducted among chronic disease patients attending a health centre in an urban area of Jodhpur, Rajasthan. A interviewer administered semi-structured questionnaire was pilot tested and validated prior to initiation of data collection. A total of 520 patients were enrolled for the study.

Results:
Poor adherence to health behaviour was observed among a majority of the respondents (infrequent physical activity: 72.0%, one or less fruit serving per day: 96.5%, one or less vegetable serving per day: 88.8%). A factor analysis revealed three domains of COVID-19 preventive behaviour: sanitisation, preventive hygiene and social distancing. Multiple regression revealed respondents opting for COVID-19 screening and those with lower salt intake followed the overall and individual COVID-19 preventive behaviour.

Conclusion:
The health behaviour assessment and inter-personal counselling by the health care providers at the primary health facilities may contribute to the increasing adherence for the COVID-19 preventive behaviour among chronic disease patients.