bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and Effectiveness of Transvaginal Mesh Placement in Treating Pelvic Organ Prolapse
Authors: Chen Zeyu , Li Shuaishuai , Ashok Raj , Xue Ning , Zhu Haitao 
Published: September 2022

Abstract
Objective
To observe the clinical effect and complications of transvaginal mesh (TVM) placement on treating pelvic organ prolapse (POP).
Methods
From May 2014 to June 2017, 89 patients with moderate to severe pelvic organ prolapse and pelvic floor defect (PFD) had received TVM pelvic reconstruction at our hospital. The operation time, intraoperative blood loss and intraoperative complications of all patients were recorded, and the incidence of postoperative complications was also observed. In addition, the POP-Q was utilized to evaluate the severity of POP in patients before surgery, as well as at 6 weeks, 6 months, 12 months and 24 months after surgery, respectively; besides, the Pelvic Floor Influence Questionnaire-7 (PFIQ-7), Pelvic Floor Dysfunction Inventory 20 (PFDI-20), and Patient Global Impression of Improvement (PGI-I) were adopted to evaluate the quality of life of patients.
Results
All the 89 cases had successfully completed the surgery, with the operation time of 60.0 ± 13.0 min and the intraoperative blood loss of 57.2 ± 21.9 mL. All patients had no bladder or rectal injury during the surgery. 2 patients displayed asymptomatic recurrence ,10 cases had postoperative fever, while 3 had mesh exposure, and all of them were improved after symptomatic treatment. Upon discharge, the lumbosacral and pubic discomfort, as well as pelvic organ dragging sensation had disappeared in all patients. In the final follow-up, the PFIQ-7 and PFDI-20 scores in the 89 cases were reduced compared with those before surgery (Ps < 0.05).
Conclusions
TVM placement is effective on treating moderate to severe POP, which is associated with a lower complication rate and higher postoperative satisfaction.
IL36G genetic variant is independently associated with susceptibility, severity and joint involvement in psoriasis
Authors: Moreira Cássio Rafael , de Alcântara Camila Cataldi , Flauzino Tamires , Martin Ligia Marcia Mario , Lozovoy Marcell Alysson Batisti , Reiche Edna Maria Vissoci , Simão Andrea Name Colado 
Published: September 2022

Abstract

Objective and design: A case-control study evaluated the association of the IL36G C>T (rs13392494) and the IL36G A>G (rs7584409) variants with susceptibility, joint involvement and severity of psoriasis (PsO).
Material: 154 PsO patients and 154 controls were included. The Classification Criteria for Psoriatic Arthritis and the Psoriasis Area and Severity Index (PASI) were determined. The variants were genotyped using the real-time polymerase chain reaction.
Results: PsO patients were older and had higher body mass index than controls (p<0.001); 95.8% of the patients had plaque PsO; 16.1% had PsA, and 27.9% had PASI > 10. The IL36Grs1339294 variant showed no association with PsO while the IL36G rs7584409 variant showed a protective effect in PsO. The G allele of the IL36G rs7584409 was positively associated with PASI >10 (p=0.031) and the GG genotype of this variant was associated with the presence of PsA (p=0.014). The C/A haplotype in a recessive model (CACA versus C/G and T/A carriers) was associated with PsO (p=0.035) while the C/G haplotype in a dominant model (C/A carriers versus C/G and T/A carriers) showed a protective effect for PsO (p=0.041). Conclusion: The G allele of the IL36G rs7584409 variant was associated with protection to PsO, higher PASI and PsA than the A allele suggesting that this variant may be a potential genetic biomarker to predict severity and joint involvement of the PsO.
Autonomy-supportive environments for people with dementia: an evidence-based review
Authors: LI JIAJING 
Published: September 2022

Abstract
Background: As one of the core principles of Person-centered Care, supporting the autonomy of residents with dementia has received increasing attention worldwide. Supportive physical environments play an important role in promoting autonomy in the everyday life of residents in care facilities. However, there is no universal definition for autonomy in everyday life, nor focused research on autonomy-supportive environments. Thus, this study aims to systematically review the existing evidence of autonomy-supportive design features based on a synthesized concept analysis of autonomy in everyday life.
Methods: A synthesized concept analysis on autonomy was conducted based on related definitions of autonomy in design guidelines and environmental assessment tools of elderly care facilities. Using keywords from the concept analysis, multiple databases including PubMed, Web of Science, CINAHL, PsycINFO, and Dementia Design Info were used to carry out a systematic review on autonomy-supportive environmental design features for people with dementia. Additional guidelines and standards were manually searched. The design features supported by empirical studies and studies based on experts’ experience were extracted from the literature. The evidence intensity of each feature was assessed according to the quality and quantity of related studies.
Results: Four domains of autonomy, freedom, independence, control, and choice emerged based on the concept analysis. 78 autonomy-supportive design features were extracted from the literature. Features are summarized into eight categories: building layout, circulation space, living room, dining space, bathroom, bedroom, outdoor space, and details. 60% of design features in the category of building layout have been cross-validated by empirical studies, while only 25% of the overall design features have.
Conclusions: Results of this review show that numerous design features of the physical environment can support the autonomy of people with dementia in the four domains. Features of building layout are well researched and the evidence intensity for the rest design features still need to be improved through future empirical studies.
An ultrastructural change in the fat body of Desert Locust Schistocerca gregaria (Orthoptera: Acrididae) treated with zinc chromium oxide nanostructures via facile chemical coprecipitation
Authors: Hashem Fatma M. , Elgazzar Elsayed , Mostafa Wageha A. 
Published: September 2022

Abstract
Background

The present work aims to investigate the ultrastructural changes in the fat body of fifth nymphal instars Schistocerca gregaria (Orthoptera: Acrididae) treated with zinc chromium oxide (ZnCrO).

Methodology:

The nanoparticles (NPs) were prepared by a coprecipitation approach. X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) were employed to investigate the structural, composition, and morphological properties.

Results and discussion

The ZnCrO NPs exhibited a hexagonal polycrystalline structure. SEM and TEM micrographs described the surface nature of the nanoparticles composed of spherical and hexagonal shapes with an average size of ~25 nm. The energy gap (Eg)of the Cr-doped ZnO thin film was estimated from the transmittance and reflectance spectra to be 3.307 and 3.840 eV. In biological sections, TEM images demonstrated that the fat body strongly impacted with the concentrations 2mg of the treated nanoparticles caused great agglomerated chromatin in the nucleus as well as haemoglobin cells (HGCs) pierced with malformed trachea. In addition, the same effect was observed at 1mg on the 7th day post treatment

Conclusion

The results indicate a positive impact of ZnCrO on Schistocerca gregaria leads to malformed of fat body organelles.
Cutaneous Body Image (CBI) in patients with hidradenitis suppurativa (HS): a hospital- based cross-sectional study.
Authors: Koumaki Dimitra , Katoulis Alexander , Apokidou Erato Solia , Rovithi Evangelia , Papadakis Marios 
Published: September 2022

Abstract
Introduction: Hidradenitis suppurativa (HS) has been linked with body image (BI) impairment and reduced quality of life (QoLWe sought to evaluate the associations between Cutaneous Body Image (CBI) and disease severity in HS patients.
Materials and methods: Between July 2020 and January 2022, a cross-sectional study was carried out including consecutive HS patients above the age of 16 who attended the Dermatology Department of a University Hospital. Disease Severity was graded with Hurley stage, HS-Physician’s Global Assessment (HS-PGA) scale, the Modified Sartorius scale (MSS), and Hidradenitis Suppurativa Clinical Response (HiSCR) score. Patients completed ten survey instruments including Patients’ Severity of disease, pain and pruritus scale, CBI, BI, Dermatology Quality of Life Index (DLQI), Skindex-16, EQ5D 5L, EQ- visual analogue scale (VAS), PHQ9, and GAD7.
Results: In total, 70 HS patients above 16-year-old participated, mean [SD] age, 34.44 [11.64] years; 49/70 (70%) males and 21/70 (30%) females. Mean± SD CBI, DLQI, Skindex-16 total, EQ-5D-5L, EQ VAS, PHQ9 and GAD7 were 5.59 ±1.58, 11.70±8.88, 52.90±27.75, 0.75±0.21, 62.48±21.12, 7.64±5.56, 7.87±5.23 respectively. Moderate to severe CBI dissatisfaction was reported by 36/70 (51.42%) patients. CBI was correlated with educational level (p<0.01, r=0.306), BI appearance evaluation (AE) (p<0.01, r=0.544), body areas satisfaction (BASS) (p<0.01, r=0.481), and overweight preoccupation subscale (OWPS) (p<0.01, r=-0.267), and Skindex-16 (p<0.01, r=-0.288).
Conclusion: Our study found that the mean of CBI in HS patients was 5.59 ± SD 1.58 and this was correlated with AE, BASS, OWP, and Skindex-16.
Reliability and validity of Chinese version of the Transition Shock Scale for Newly Graduated Nurses (TSSNGN)
Authors: Du Li , Fang Shu , Zhang Junxian , Hu Fen , Chen Jie , Lu Baili , Zhang Qing , Bilong Feng , Luo Dan 
Published: September 2022

Abstract
Background: New nurse graduates encounter a myriad of experiences in their first employment setting as a result of the lack of knowledge, specialized skills, transition shock, and other aspects of the situation. There is a lack of tools to assess the experiences encountered during the transition process in China. The aim of this research was to explore the reliability and validity of Chinese version of the Transition Shock Scale for Newly Graduated Nurses (TSSNGN) among recent Chinese nurse graduates.
Methods: The Korean version of TSSNGN was translated and culturally adapted by Beaton and his colleagues based on the instrumental adaptation process. A methodological research design was adopted for the study. Newly graduated Chinese nurses (N=327) were recruited using convenience sampling method. All of the participants were investigated by the Chinese version of the TSSNGN and a socio-demographic questionnaire. The content, construct, convergent, discriminant, and criterion-related validity and the reliability of the scale were examined.
Results: The TSSNGN Korean version includes 18 items. A modified index was used to improve the model fit and it supported the reliability of the Korean version of the TSSNGN model. Analysis of fit of the revised Chinese model using Nomed χ2 (CIMIN/df) showed: ﬁt indices to 3.09, RMSEA = 0.07, RMR=0.03, GFI= 0.90, IFI =0.92, TLI=0.90, CFI=0.92. Criterion validity compared to the PSS showed significant correlation, and the Cronbach’s alpha was 0.92. Factor loadings of the 18 questions ranged from 0.49 to 0.87.
Conclusions: The simplified Chinese version of the TSSNGN is valid and reliable to assess the transition shock of newly graduated Chinese nurses.
Developing a geochemical quality index for mangrove systems in the South Western Coast of Indian Peninsula
Authors: Renuka Rajan , Sandeep Sasidharan , Sreej Kalapuzha Ashtamoorthy , Sreeku Vadakethil Balakrishnan , Kumar Rakkodan Anil 
Published: September 2022

Abstract
Mangroves are vital components of the environment providing diverse functions from biodiversity conservation to climate regulation. Understanding the soil quality in these systems is essential for appropriate decision making and developing strategies for sustainable mangrove soil management. The objective of the study was to develop a Geochemical Quality Index (GQI) and Relative Geochemical Index (RGQI) for soil quality assessment of the mangrove systems. A total of 63 soil samples were collected from the surface layer 0 to 30 cm, for assessing the physico – chemical parameters from the mangrove systems along the South Western Coast of Penisnsular India. The datasets were subjected to principal component analysis (PCA) to derive the minimum data set for the GQI and RGQI. The selected parameters were ranked based on their performance of soil functions and combined to form the indices. The PCA results showed that, percent sand, percent silt, percent clay, Cu, EC, Fe and K were the most representative variables of mangrove ecosystem health. The RGQI values indicated the relative quality of mangrove soils in the region with respect to maximum attainable geochemical health and classified the mangrove systems into 3 types vis - a - vis; good, medium and poor. Evaluation of the existing mangrove systems using RGQI revealed that majority of the mangrove systems in the South Western coast of Peninsular India had a high probability to progressively alter from ‘good’ to the ‘poor’ category, hence mandate crucial management strategies.
Exploring public acceptability of direct air capture and storage: Climate urgency, moral hazards and perceptions of the whole versus the parts of a carbon dioxide removal system
Authors: Satterfield Terre , Nawaz Sara , Laurent Guillaume Peterson-St. 
Published: September 2022

Abstract
Negative emission technologies (NETs) or the drawdown of atmospheric carbon is increasingly essential to meeting climate targets. Many options (e.g., afforestation) may not however meet the scale of removal and permanence of storage needed. Scientists and engineers are thus turning to new alternatives involving technology bundles using direct air capture of C02 and storage. However, the social acceptability of these is presumed unlikely given the sheer complexity of their components, governance arrangements, perceived advantages and disadvantages, and the different moral and value positions at play. This paper explores public perceptions of a proposed system including above sea and potentially more positively viewed components (wind energy to power direct air capture of carbon) alongside deep-ocean and potentially more negatively perceived components (injection and storage as carbonate rock). Using a representative survey of n = 2120 US and Canadian residents nearest a proposed system pilot, analysis reveals two very different profiles of perceivers, pro and con. Rejection of the system as a whole is driven by concern for storage or below sea components, physical risks (e.g., leakage), and belief that such a system constitutes a moral hazard, enabling continued fossil fuel dependence. Conversely, those who support such a system perceive it as economically, climatically, and ethically beneficial now and for future generations, express a strong sense of climate severity and urgency, and see themselves as responsible for natural systems. We close with cautions as to the social licence for negative emission technologies, and the fragility of hope as these possibilities unfold.
Developing hybrid XGBoost model integrated with entropy weight and Bayesian optimization for predicting tunnel squeezing intensity
Authors: Geng Xiaojie , Wu Shunchuan , Zhang Yanjie , Sun Junlong , Cheng Haiyong , Zhang Zhongxin , Pu Shijiang 
Published: September 2022

Abstract
Tunnel squeezing is a large deformation problem closely related to creep and severely affects tunnel construction safety and efficiency. In this paper, the extreme gradient boosting (XGBoost) model is optimized using a combination of the Bayesian optimization (BO) algorithm and the entropy weight method (EWM) to accurately predict the tunnel squeezing intensity based on a dataset of 139 tunnel case histories. In order to mine the information contained in the prediction indices, the EWM is used first to pre-process the sample data and eliminate the effect of large differences in the input parameters’ values among different dimensions. On the other hand, the BO algorithm is applied to optimize the XGBoost model’s important hyperparameters, thus improving its performance effectively. As a part of the study, the strength-stress ratio (SSR), rock mass quality index in the BQ system ([BQ]), tunnel diameter (D), and support stiffness (K) are selected as inputs to the tunnel squeezing estimation model. Within the study context, the prediction accuracy (Acc) and kappa coefficient (k) of the EWM-BO-XGBoost, XGBoost, BO-XGBoost, Evidence Theory (ET), Random Forest (RF), Support Vector Machine (SVM), and Decision Tree (DT) models are computed and compared. The study results have shown that the Acc (91.7%) and k (0.89) of the EWM-BO-XGBoost model are the highest, which proves its reliability and superiority against other alternatives. In addition, the analysis of the prediction indices’ feature importance showed that the SSR contributes the most to the squeezing intensity, followed by the [BQ] and D, while the K has the least effect on the squeezing intensity.
Fertilization via soil with boric acid in Dipteryx odorata (Aubl.) Willd. seedlings
Authors: MARIA LUCIANO DE SOUZA , Caione Gustavo , Prado Renato de Mello 
Published: September 2022

Abstract
Background and aims: The importance of boron (B) in the growth and development in native tree species are relevant to establish quality indexes for seedlings. The objective of the present study was to evaluate the effect of boron application on the development of Dipteryx odotara seedlings.
Methods: The experimental design was a completely randomized design, five treatments with four replications. The treatments consisted of B doses, in the form of boric acid (17% of B), being: 0; 1.0; 10; 20 and 40 mg B kg-1. We evaluated the seedlings were at 60 days after transplanting.
Results and Conclusions: The dose 1 mg B kg-1 and absence of application in Dipteryx odotara seedlings provided the highest values ​​of stem diameter, shoot height, root volume and dry mass of shoot, root and total. It also provided better quality indexes for seedlings: shoot height/shoot dry matter, shoot dry mass/root dry mass and Dickson quality index, did not show symptoms of B toxicity in plants. Unlike the other doses that affected the growth and development of Dipteryx odotaraseedlings.
A study on endoscopy artefact detection based on deep learning
Authors: Zhang Han , Adjei Prince , Hu Xiaoming , Wang Xiaotong , Hu Yeting , Gan Tao , Rao Nini 
Published: September 2022

Abstract

Endoscopic images are generally corrupted by various artefacts, such as blur caused by the irregular motion of endoscopists or organ peristalsis, preventing endoscopists from performing efficient and high-accuracy diagnosis and limiting the utility of computer-aided diagnosis in endoscopy. As a result, an endoscopy artefact detection algorithm that is both robust and reliable is critical in endoscopic imaging. This study proposes an endoscopy artefact detection method based on an improved Faster Region-based Convolutional Neural Network (Faster R-CNN) detector, simply named Faster RFD3-CNN. We introduce deformable convolutions and a feature pyramid network (FPN) to strengthen the model's adaptability and feature extraction ability. Furthermore, class-aware non-maximum suppression (NMS) and false positive elimination are utilized to filter out some bounding boxes with low confidence or overlap. The experimental results on the public access EndoCV2020 data set show that the mean average precision (mAP) can reach 42.66% and the intersection of union (IoU) is 31.61%. The mAP is increased by nearly 15% compared with the existing methods. Compared with the basic Faster R-CNN, mAP and IoU are improved by 7.39% and 11.19%, respectively. To sum up, the proposed method in this paper has superior performance in endoscopy artefact detection.
Global loss of fine-scale chromatin architecture and rebalancing of gene expression during early colorectal cancer development
Authors: Snyder Michael , Zhu Yizhou , Lee Hayan , Weimer Annika , Horning Aaron , Nevins Stephanie , Esplin Edward , Paul Kristina , Krieger Gat , Shipony Zohar , Mills Meredith , Laquindanum Rozelle , Ladabaum Uri , Chiu Roxanne , Longacre Teri , Shen Jeanne , Jaimovich Ariel , Lipson Doron , Kundaje Anshul , Greenleaf William , Curtis Christina , Ford James 
Published: September 2022

Abstract

Although 3D genome architecture is essential for long-range gene regulation, the significance of distal regulatory chromatin contacts is challenged by recent findings of low correlation between contact propensity and gene expression. To better understand the role of long-range interactions between distal regulatory elements during the early transformation from healthy colon to colorectal cancer, here we performed high resolution chromatin conformation capture for 33 samples including non-neoplastic mucosa, adenomatous polyps and adenocarcinomas, mostly from Familial Adenomatous Polyposis (FAP) patients. We identified hundreds of thousands of chromatin micro-structures, such as architectural stripes and loops, which originated from active cis-regulatory elements. Surprisingly, these structures progressively decayed throughout cancer progression, particularly at promoters. Meta-analyses revealed that this decay was independent of alterations in DNA methylation and chromatin accessibility. Interestingly, the degree of interaction loss was poorly correlated with gene expression changes. Instead, genes whose expression were disproportionately lower and higher than their relative promoter interaction in mucosa shifted their expression in polyps and adenocarcinomas to yield a more direct relationship between strength of interaction and gene expression. Our work provides the first high resolution 3D conformation maps during early cancer formation and progression, and provides novel insights into transcriptional readouts associated with fine-scale chromatin conformation alterations.
Radiologic Features of Hysterectomized Patients with Lumbar Disc Herniation: A Case Control Study
Authors: Zhang Yuchen , Wang Lianlei , Chen Xing , Ibrahim Yakubu , Sun Qingyu , Tian Yonghao , Yuan Suomao , Zhang Jianmei , Liu Xinyu 
Published: September 2022

Abstract
Objective: To analyze the effect of hysterectomy on radiologic lumbar spine degeneration in patients with lumbar disc herniation.
Methods: The medical records of 95 female patients aged over 45 years diagnosed with lumbar disc herniation from January 2016 to December 2021 were retrospectively analyzed and grouped according to their hysterectomy status. Thirty-five patients were assigned to the hysterectomy group (HR group) and 60 to the non-hysterectomy group (NHR group). Computerized tomography (CT), magnetic resonance imaging (MRI), and lateral lumbar spine radiographs were used to examine various radiological imaging parameters between the groups.
Results: No significant differences in patient characteristics among the groups were found. Functional cross-sectional area and standardized functional cross-sectional area of the psoas and erector spinae muscles at L3-L4, L4-L5, and L5–S1 were significantly lower in the HR group (P <0.05). The radiological density of the psoas major and multifidus muscles at L3-L4 to L5-S1, and erector spinae at L4-L5 to L5-S1 was significantly lower in the HR group (P <0.05). The prevalence of facet joint degeneration was significantly higher in the HR group (P <0.05). The degree of lumbar disc degeneration and vertebral endplate damage was significantly greater in the HR group (P <0.05). The incidence of Modic changes was significantly higher in the HR group (P <0.05). No significant difference in MSU classification of lumbar disc herniation across the groups was found. Disc height index throughout the lumbar spine was significantly lower in the HR group (P <0.05).
Conclusions: Hysterectomy may accelerate the degeneration of lumbar paravertebral muscles, facet joints, intervertebral discs, and endplates.