bluuebunny/crossref_metadata_2025_split huggingface dataset:
Embedding cognitive framework with self-attention for interpretable knowledge tracing
Authors: Pu Yanjun , Wu Wenjun , Peng Tianhao , Liu Fang , Liang Yu , Yu Xin , Chen Ruibo , Feng Pu 
Published: October 2022

AbstractRecently, deep neural network-based cognitive models such as deep knowledge tracing have been introduced into the field of learning analytics and educational data mining. Despite an accurate predictive performance of such models, it is challenging to interpret their behaviors and obtain an intuitive insight into latent student learning status. To address these challenges, this paper proposes a new learner modeling framework named the EAKT, which embeds a structured cognitive model into a transformer. In this way, the EAKT not only can achieve an excellent prediction result of learning outcome but also can depict students’ knowledge state on a multi-dimensional knowledge component(KC) level. By performing the fine-grained analysis of the student learning process, the proposed framework provides better explanatory learner models for designing and implementing intelligent tutoring systems. The proposed EAKT is verified by experiments. The performance experiments show that the EAKT can better predict the future performance of student learning(more than 2.6% higher than the baseline method on two of three real-world datasets). The interpretability experiments demonstrate that the student knowledge state obtained by EAKT is closer to ground truth than other models, which means EAKT can more accurately trace changes in the students’ knowledge state.
Biofunctional soy-based sourdough for improved rheological properties during storage
Authors: Teleky Bernadette-Emőke , Martău Gheorghe Adrian , Ranga Floricuța , Pop Ioana Delia , Vodnar Dan Cristian 
Published: October 2022

AbstractFrozen dough storage, along with its thawing process, negatively affects the quality of the final product. Thus, fermentation with selected cultures and the enrichment of wheat-based dough using a specific soy powder could optimize the viscoelastic quality of frozen dough and increase its nutritional characteristics. Based on these aspects, the present study’s objective was to examine the effects of soy powder addition to wheat flour with single cultures of Fructilactobacillus florum DSM 22689 or Saccharomyces cerevisiae and coculture with these two microorganisms for 72 h of fermentation. Additionally, the fermentation process was monitored, and viscoelastic behavior and physical–chemical analyses of the fermented sourdough before and after frozen storage were assessed, as soy protein has been proposed to hinder water migration throughout frozen storage. As observed, soy powder, an essential functional ingredient, had a favorable impact on the water-starch-gluten system, and enhanced the viscoelastic behavior before and after 4 weeks of frozen storage.
Randomized, double-blinded, controlled clinical trial of the effect of captopril, telmisartan and their combination on systemic inflammation of patients on hemodialysis
Authors: Ordaz-Medina Susan M. , Cueto-Manzano Alfonso M. , González-Plascencia Juana , Montañez-Fernández José L. , Ordaz-Medina Elias J. , Martín-del-Campo Fabiola , Cueto-Ramírez Alfonso M. , Martínez-Martínez Petra , Cortés-Sanabria Laura , Rojas-Campos Enrique , Trujillo-Hernández Benjamín 
Published: October 2022

AbstractTo evaluate individual and combined effect of captopril and telmisartan on systemic inflammation markers of hemodialysis (HD) patients. Randomized, double-blinded, controlled clinical trial. Patients on HD at least 2 months, with arteriovenous fistula, were randomly allocated to groups: (1) captopril/placebo (N 13); (2) telmisartan/placebo (N 13); (3) captopril + telmisartan (N 12); or (4) placebo/placebo (N 12). During 3 months, patients received oral drugs as follows: captopril 50 mg/day, telmisartan 80 mg/day or placebo. Patients excluded if they had conditions or were on drugs potentially influencing on inflammation. Clinical and biochemical evaluations were performed monthly. Serum tumor necrosis factor alpha (TNFα), interleukin 6 (IL-6), and C-reactive protein (CRP) were measured at 0, 1 and 3 months. Baseline, demographic, clinical and biochemical variables were comparable between groups. Baseline versus final inflammatory markers were: captopril/placebo TNFα, 2.47 (0.1–4.5) versus 1.73 (0.3–3.8) pg/ml; IL-6, 17.03 (7.2–23) versus 7.90 (0.7–19) pg/ml; CRP, 4.21 (1.6–18) versus 5.9 (3.0–28) mg/l; telmisartan/placebo TNFα, 3.03 (2.3–4.6) versus 1.70 (1.2–2.0) pg/ml; IL-6, 14.10 (5.5–23) versus 9.85 (6.2–13) pg/ml; CRP, 5.74 (2.1–13) versus 10.60 (1.5–27) mg/l; captopril + telmisartan TNFα, 1.43 (0.7–5.4) versus 0.40 (0.1–2.1) pg/ml; IL-6, 10.05 (4.9–23) versus 4.00 (0.7–7.7) pg/ml (p < 0.05); CRP, 3.26 (0.7–12) versus 2.83 (0.6–6.5) mg/l; placebo/placebo TNFα, 3.13 (1.6–5.6) versus 1.64 (1.6–2.3) pg/ml; IL-6, 8.12 (5.4–16) versus 7.60 (2.4–15) pg/ml; CRP, 5.23 (1.9–16) versus 3.13 (1.5–18) mg/l. Monotherapy with captopril or telmisartan display a trend, but their combined treatment significantly decreased serum levels of IL-6. No remarkable changes on TNFα and CRP were observed.
The additive effect of genetic and metabolic factors in the pathogenesis of nonalcoholic fatty liver disease
Authors: Seko Yuya , Yamaguchi Kanji , Yano Kota , Takahashi Yusuke , Takeuchi Kento , Kataoka Seita , Moriguchi Michihisa , Itoh Yoshito 
Published: October 2022

AbstractBoth genetic and metabolic factors influence the pathology of nonalcoholic fatty liver disease (NAFLD). The aim of this retrospective study was to evaluate the impact of these factors at each stage of disease. We analysed the impact of obesity, diabetes mellitus and genetic risk factors (alleles ofPNPLA3orHSD17B13) on nonalcoholic steatohepatitis (NASH), significant fibrosis (stage ≥ 2) and advanced fibrosis (stage ≥ 3) in 346 patients. Genetic high risk was defined as having at least 2 risk alleles. The median age was 59 years, median body mass index was 27.1 kg/m2, and 46.8% had diabetes mellitus. Obesity was a risk factor for NASH, significant fibrosis, and advanced fibrosis. Diabetes mellitus increased the risk of NASH. Genetic risk increased the risk of significant and advanced fibrosis. Odds ratios for NASH, significant fibrosis and advanced fibrosis increased with the number of genetic and metabolic risk factors. The patients with both metabolic and genetic risks had an odds ratio of 12.30 for NASH, 5.50 for significant fibrosis, and 6.25 for advanced fibrosis. Factors strongly impact on the pathology of NAFLD differed according to the fibrosis stages. Synergistic effects were observed between genetic and metabolic factors at all stages.
A Scoping Review and Tutorial for Developing Standardized and Transparent Protocols for Flexible Endoscopic Evaluation of Swallowing
Authors: Curtis James A. 
Published: October 2022

Purpose:
Standardization and transparency are essential components for enhancing an assessment's objectivity and reproducibility. Currently, it is up to the individual clinician to develop a standardized protocol that works for their clinical setting and patient populations. Therefore, the primary aim of this clinical focus article is to present a scoping review of research that can aid clinicians as they develop standardized and transparent protocols for flexible endoscopic evaluation of swallowing (FEES).

Method:
A brief background is provided characterizing the diagnostic advantages and limitations of FEES and describing why increased standardization and transparency for the performance of FEES is needed. Research examining examination preparation parameters (topical nasal anesthetics, vasoconstrictors, lubrication, anxiety) and swallowing protocols (swallowing instructions, bolus volumes, bolus consistencies, number of trials, colorants) is then explored. Last, step-by-step instructions and examples on developing a protocol are outlined.

Conclusions:
FEES is a gold standard approach for examining functional swallowing outcomes in people with known or suspected dysphagia. Standardizing and transparentizing the performance of FEES, the swallowing protocol, and the rating methods are critical for successful use of FEES in clinical and research practices.
Comparison of machine learning algorithms to predict optimal dwelling time for package tour
Authors: Wahyutama Aria Bisma , Hwang Mintae 
Published: October 2022

AbstractThis paper shows the comparison between several well‐known classification algorithms in Machine Learning with the purpose of finding the most suitable algorithm to predict the dwelling time, that is, how long a certain tourist should stay in a particular tourist spot. This dwelling time prediction can be adopted by tour and travel agents to provide optimal scheduling for their package tours. The algorithm in question is strictly for classification because in this case, the dwelling time does not require a very specific number of minutes; thus, the time can be classified and restricted into several time frames. The origin and features of the dataset are described in this paper as well as the comparison methodology to show the procedure of how the comparison was made. Lastly, the performance results will be used to determine which algorithm to use for this specific case and it will be shown in a form of a graph.
Individuelle somatische Klassifikation von Neugeborenen auf der
Grundlage von Körperhöhe und Körpergewicht der Mutter
(Ergebnisse einer Validierungsstudie)
Authors: Voigt Manfred , Nikischin Werner , Hentschel Roland , Strauss Alexander , Kunze Mirjam , Ensenauer Regina , Wittwer-Backofen Ursula , Hagenah Hans-Peter , Olbertz Dirk , Rochow Niels 
Published: October 2022

ZUSAMMENFASSUNG
Einleitung Das Geburtsgewicht ist u. a. durch die
mütterliche Größe beeinflusst. Die SGA-Rate Neugeborener
relativ kleiner und leichter Mütter
(<158 cm,<53 kg) und die LGA-Rate relativ
großer und schwerer Mütter
(+> 177 cm,>79 kg) werden
überschätzt. Die LGA-Rate Neugeborener relativ kleiner und
leichter Mütter und die SGA-Rate relativ großer und schwerer
Mütter wird unterschätzt. Individualisierte
Geburtsgewichtsperzentilen (IGGP) basierend auf 18 Müttergruppen (6
Körperhöhengruppen mit jeweils 3 Gewichtsgruppen), Geschlecht
und Schwangerschaftswochen wurden publiziert. Das Ziel dieser Studie ist die
Validierung der IGGP durch Evaluierung der SGA-, AGA- und LGA-Raten an einem
unabhängigen Perinataldatensatz.
Methoden Die Validierungsstudie vergleicht IGGP (1995 bis 2000,
n=2,2 Mio Einlingsschwangerschaften) mit Perzentilwerten aus zwei
gesamtdeutschen Kohorten (i: 1995 bis 2000; n=2,3 Mio und ii: 2007 bis
2011, n=3,2 Mio) anhand von Neugeborenen der niedersächsischen
Perinatalerhebung (n=0,56 Mio Einlingsschwangerschaften von 2001 bis
2009). SGA-, AGA- und LGA-Raten werden berechnet mit dem Statistikprogramm
R.
Ergebnisse Die Perzentilwerte der Gesamtpopulation 1995–2000 bzw.
2007–2011 ergaben SGA-Raten bei relativ kleinen und leichten
Müttern von 21,1 bis 21,6% und LGA-Raten von 2,0 bis
3,1%. Bei relativ großen und schweren Müttern waren die
SGA-Raten von 3,3 bis 3,5% und die LGA-Raten von 26,6 bis 27,1%.
Die IGGP erreichten SGA-Raten von 9,0% und LGA-Raten von 11,4 bis
11,6% bei relativ kleinen und leichten Müttern sowie SGA- und
LGA-Raten von annähernd 10% bei relativ großen und
schweren Müttern.
Diskussion IGGP berücksichtigen das Wachstumspotential von Feten
entsprechend der mütterlichen Größe und erreichen die
erwarteten SGA- und LGA-Raten von 10%. Die Berücksichtigung des
individuellen Wachstumspotential vermeidet ein Unter- und
Überschätzen von SGA- und LGA-Raten. IT-unterstützte
Analysen des Geburtsgewichtes mit IGGP vereinfachen die Anwendung.
Evidenzbasierte Lokaltherapie chronischer Wunden
Authors: Dissemond Joachim , Lobmann Ralf 
Published: October 2022

ZusammenfassungChronische Wunden sind zumeist durch Grunderkrankungen wie Diabetes mellitus oder Gefäßerkrankungen bedingt und stellen eine große Problematik in der zunehmend alternden Gesellschaft dar. Die inadäquate Behandlung geht oftmals mit protrahierter Wundheilung, erhöhten Risiken für Komplikationen, eingeschränkter Lebensqualität der Betroffenen und langwierigen Therapien mit hohen Behandlungskosten einher.Die erfolgreiche Therapie setzt eine frühzeitige adäquate Diagnostik, Kausaltherapie sowie Wundbehandlung möglichst auf Basis evidenzbasierter Medizin voraus. Diese Behandlung sollte dann in qualifizierten Versorgungsstrukturen anhand konkreter Behandlungspfade erfolgen. Somit können in der täglichen Praxis eine verbesserte Wundheilung mit gesteigerter Lebensqualität der Patienten sowie ein medizinökonomischer Vorteil erreicht werden.In diesem Übersichtsartikel wird die evidenzbasierte Lokaltherapie chronischer Wunden mit Schwerpunkt auf Wundverbänden mit TLC-Sucrose-Octasulfat-Beschichtung dargestellt. Leitlinien und Behandlungspfade sowie pharmaökonomische Aspekte werden dabei berücksichtigt.
How Important are Psychological Measures to Determine Readiness to Return to Sports after Reconstruction of the Anterior Cruciate Ligament? An Online Survey Study
Authors: Newmarch Tate , Betsch Marcel , Michalik Roman , Dwyer Tim , Whelan Daniel , Chahal Jaskarndip , Theodoropoulos John 
Published: October 2022

Abstract
Background Recent studies have suggested that psychological factors are important components of a successful return to sports (RTS) after anterior cruciate ligament reconstruction (ACLR). The purpose of this study was to survey physicians with respect to their criteria used to determine readiness to RTS after ACLR and to understand the significance of psychological factors on RTS.
Methods A survey was designed to understand the practices of clinicians managing rehabilitation after ACLR, consisting of 25 questions divided into 3 different sections, including one section about psychological scores and factors affecting RTS. The survey was delivered to three North American organizations for orthopedic sports medicine.
Results The total number of respondents was 113. Of the respondents, 95% considered psychological tests at least “somewhat important” (33% “important”, 23% selected “very important”). Routine use of psychological tests in practice was only reported by 35% of respondents. The ACL-Return to Sport after Injury Scale was the most frequently used psychological test (23%). Fear of reinjury was considered the most common patient-cited psychological factor affecting RTS. Psychological factors ranked 8th out of 9 outcomes measures in determining readiness to RTS.
Conclusion This study demonstrates a discrepancy between the importance of psychological tests and the frequency of use in practice. Additional education on this topic, web-based applications, and a multidisciplinary approach may increase the usage of psychological tests to determine RTS after ACLR.
Study of PD-L1 Expression with Association of Pathological Factors and Molecular Subtypes in Breast Carcinoma
Authors: Gupta Abhishek , Chandra Smita , Chauhan Neena , Arora Anshika 
Published: October 2022

Abstract
Background Programmed death ligand 1 (PD-L1), expressed on cancer cells, shows varied results in the prognosis of breast cancer. This study was conducted to study the expression of PD-L1 in breast carcinoma and to correlate it with pathological, molecular classification and prognostic factors.
Materials and Methods PD-L1 expression was correlated with tumor size, histopathological grade, necrosis, lymphovascular, perineurial invasion, lymph node metastasis, molecular classification, and survival in breast carcinoma cases.
Results Fifty cases were included which showed statistically significant difference of PD-L1 with mean age, tumor size, histopathological grade, lymphovascular emboli, and lymph node metastasis (p < 0.05). Estrogen receptor was strongly positive in 46%, progesterone receptor in 42%, and PD-L1 in 6% of cases. No statistically significant difference between pathological tumor–node–metastasis (TNM) staging and PD-L1 expression (p = 0.354) was observed. Receptor operating characteristic curve analysis showed that at the cutoff of PD-L1 greater than 120, specificity was 56.1%, sensitivity 66.7%, negative predictive value 88.5%, and positive predictive value 25% for predicting living status.
Conclusion PD-L1 is associated with poor prognostic factors including tumor size, histopathological grade, lymphovascular emboli, and lymph node metastasis in breast carcinoma. However, no significant association was observed between PD-L1 and pathological TNM stage or molecular subtypes of breast carcinoma. It is suggested that immunohistochemical reporting of PD-L1 should be standardized so that it is reproducible and reliable for the evaluation of breast carcinoma. Further, larger studies with extended follow-ups are recommended so that the exact role of PD-L1 as a prognostic marker in breast carcinoma could be ascertained.
Ceftriaxone Resistant Salmonella enterica Serovar Kentucky as a Cause of Bacteremia and Gastroenteritis: A Case Report
Authors: Neelambike Sumana M. , Chitharagi Vidyavathi , Rao Morubagal Raghavendra , Badveti Satyasai 
Published: October 2022

AbstractSalmonella enterica serovar Kentucky is an emerging human pathogen in developed countries and also a concern for public health in developing countries. Although genus Salmonella is usually susceptible to many antimicrobial agents, a recent increase in resistance has become a cause for concern. A case of ceftriaxone resistant Salmonella enterica serovar Kentucky causing bacteremia and acute gastroenteritis is reported in this paper. The Salmonella Kentucky isolate in this case was resistant to most classes of antibiotics. This is the first case report of Salmonella enterica serovar Kentucky resistant to ceftriaxone. Multidrug resistant patterns of Salmonella Kentucky are observed globally. Awareness of various nontyphoid Salmonella causing human infections is of utmost importance, because delayed identification, serotyping, and susceptibility testing may delay the administration of antibiotics leading to worsening outcomes.
Twin Malignancy of Acute Myeloid Leukemia and Multiple Myeloma in a Chemotherapy-Naïve Patient: A Rare Occurrence
Authors: Jamal Iffat , Shuchismita Shuchismita , Choudhary Vijayanand 
Published: October 2022

AbstractSynchronous diagnosis of acute myeloid leukemia (AML) and multiple myeloma in chemotherapy-naïve patients is a rare event and poses a serious therapeutic challenge as it imparts a poor prognosis. We report a case of concurrent AML with multiple myeloma in a 44-year-old male along with a PUBMED-based research of previously reported similar cases in published literature.
Equivalence in international business research: A three-step approach
Authors: Solarino Angelo M. , Buckley Peter J. 
Published: October 2022

AbstractA primary research area within the field of international business (IB) is to establish the extent to which concepts, theories, and findings identified in one country are applicable to other contexts and which are unique and cannot be found in other contexts. Researchers in IB acknowledge the importance of the context in their studies, but the practice of assessing equivalence (or invariance) is not widely diffused within the community. We first discuss the components of equivalence (construct, method, and item equivalence), and we offer a three-step approach to address equivalence in the writing and revision of a paper. We aim to help editors, reviewers, and researchers produce more reliable research and navigate the tension between generalizable relationships and context-specific ones, both theoretically and empirically, before performing analysis and hypothesis testing. We then apply equivalence to the construct of firm economic performance as a case study, but the same logic can be applied to other constructs as well.
Individual excellence funding: effects on research autonomy and the creation of protected spaces
Authors: Jabrane Leila 
Published: October 2022

AbstractThis article contributes to the emerging body of literature which investigates the mechanisms through which funding conditions affect research. It is an interview-based case study of the Distinguished Professor Grant (DPG); an excellence funding instrument aimed at individuals. The study uses the concept of “protected space” to explore the epistemic and organizational dynamics enabled by the DPG. By virtue of their larger size and longer timeframe, excellence funding schemes are assumed to promote greater research autonomy and risk-taking, providing a “protected space”. Semi-structured interviews with DPG recipients revealed that the autonomy afforded by the funding instrument extends to three areas: epistemic, strategic, and temporal. However, this autonomy is modulated by the characteristics of the researchers and the environment in which they operate. The article concludes that, rather than involving a one-time accomplishment, enacting “a protected space” using a grant like the DPG requires constantly balancing investments and adjustments in different priority areas.
Women’s experiences of, and preferences for, postpartum contraception counselling
Authors: Li Ching Kay , Botfield Jessica , Amos Natalie , Mazza Danielle 
Published: October 2022

Background The lack of access to and uptake of postpartum contraception is a key contributor to an estimated 121 million unintended pregnancies worldwide. Research on counselling and women’s preferences for postpartum contraception is scarce in Australia. We therefore aimed to explore Australian women’s experiences of, and preferences for, accessing postpartum contraceptive counselling. Method In this qualitative study, English-speaking women of reproductive age (18–40 years) with at least one child under the age of 5 years were recruited via social media to participate in a semi-structured telephone interview. Interviews focussed on women’s experiences of, and preferences for, postpartum contraception. The interviews were audio-recorded, transcribed, coded and thematically analysed. Results Twenty women participated. Most did not receive in-depth contraceptive counselling antenatally or postnatally, though had brief discussions with their GPs or obstetricians at the 6-week postnatal check. Participants felt some counselling throughout their antenatal and postnatal care would have been useful, particularly those who experienced medical complications perinatally. Most participants expressed a general preference for their GP or a midwife to provide such counselling, rather than an obstetrician or nurse, and they noted characteristics such as compassion, trust and care as being particularly important. Conclusion The provision of postpartum contraceptive counselling could be enhanced in Australia. Contraceptive uptake in the postpartum period may be promoted by ensuring consistent and routine provision of contraceptive counselling for women antenatally and postnatally by their maternity carers.