bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avocado Consumption Increased Skin Elasticity and Firmness in Women ‐ A Pilot Study
Authors: Henning Susanne M. , Guzman Jeraldine B. , Thames Gail , Yang Jieping , Tseng Chi‐Hong , Heber David , Kim Jenny , Li Zhaoping 
Published: January 2022

AbstractBackgroundAvocados are a rich dietary source of monounsaturated fatty acids, carotenoids, and phenolic compounds. Clinical studies have demonstrated that oral consumption of carotenoids improved skin aging. However, no studies have investigated whether oral intake of avocado will reduce skin aging.ObjectivesWe therefore performed this pilot study to assess whether oral consumption of one avocado daily for 8 weeks can reduce skin aging in healthy overweight women assessing skin physical characteristics and resistance to UVB radiation.MethodsThirty‐nine female participants (age 27–73 years) with Fitzpatrick skin type II‐IV were randomly assigned to consume either one avocado daily or continue habitual diet for 8 weeks. Facial skin elasticity, firmness, pigmentation, sebum, and hydration were determined using a cutometer on the forehead and under eye. Minimal erythema dose (MED) was determined by standardized protocol at inner arm.ResultsElasticity and firmness were increased at forehead comparing 8 weeks to baseline in the avocado group. Comparing avocado to control, change in firmness marker from baseline to week 8 indicated a significant increase in forehead skin firmness in the avocado group. We did not observe any change in hydration, pigmentation, sebum, and UVB resistance between the avocado and control group, although changes in melanin and erythema were observed in both groups over time.ConclusionsOur findings suggest that daily oral avocado consumption may lead to enhanced elasticity and firmness of the facial skin in healthy women. Further studies of other skin locations are required to establish the connection between avocado consumption and skin aging.
Comparative study between the effectiveness of plasma skin regeneration versus micro‐needling in the treatment of striae distensae
Authors: Mohamad Noha E. , ELgameel Rasha M. , Mohamed Mohamed H. 
Published: January 2022

AbstractBackgroundStriae distensae (SD) or stretch marks, a common condition causing significant cosmetic concern and distress, are linear dermal scars associated with epidermal atrophy that occur due to overstretching. Recently, micro‐needling with dermapen is considered as one of the therapeutic modalities for SD. Also, plasma skin regeneration with plasma jet has been recommended as an effective method for the treatment of SD.AimThe aim was to compare between the efficacy of both methods in the treatment of SD.MethodsThis study included 30 patients with striae distensae. Body was divided into two halves; one was treated with plasma jet for two sessions with 1 month interval and follow‐up one month after the last session and the other half was treated with dermapen for four sessions with two weeks interval and follow‐up one month after.ResultsThere was no statistically significant difference (p‐ value >0.05) between dermapen and plasma jet procedures as regard to width, Total Atwal Score, Atwal score component, score of erythema, and skin texture after treatment. There was high statistically significant difference (p value <0.01) between dermapen and plasma jet as regards pain with higher values with plasma jet while there were statistical higher values concerning hyperpigmentation and erythema with dermapen. There was high statistically significant difference (p value <0.001) between width of striae before and after treatment with dermapen.ConclusionsBoth lines of treatments are effective and promising therapeutic modalities for striae distensae with minimal side effects.
Price decomposition of laser treatment for port‐wine stain using the hedonic pricing model
Authors: Jantarakolica Tatre , Wanitphakdeedecha Rungsima , Yan Chadakan , Ng Janice Natasha C. , Sudhipongpracha Tatchalerm 
Published: January 2022

AbstractBackgroundPort‐wine stain (PWS) is a congenital capillary malformation associated with negative effects on the quality of life and psychological health of the patients. Pulsed dye laser (PDL) is the current treatment of choice for PWS; however, there is little information on the factors determining the treatment price of PWS. We aim to explore the factors determining the treatment price of PWS.MethodsData were collected through telephone surveys and self‐reported questionnaires from hospitals, chain clinics, and doctor's offices that offered PWS treatment from February 1 to March 30, 2021. Data were analyzed by descriptive statistics and multivariate analysis using a log‐linear regression model.ResultsA total of 104 observations were gathered. The estimated base price of the treatment without any additional features is 98.34 USD. Treatment by dermatologists has an additional charge of 28.41 USD or 28.9%. Some private clinics offer a lower price of 28.7% (or 28.27 USD) by illegally having non‐medical doctors perform the treatment. Treatment with 595‐nm PDL and 585‐nm PDL and 1064‐nm Nd:YAG lasers has an additional charge of 34% (or 33.45 USD) and 38% (or 37.41 USD), respectively. The location and type of medical facility can also affect the price of the treatment.ConclusionMany factors determine the base price and shadow price of PWS treatment. Factors determining a higher cost of laser fee includes non‐government facilities, location within the capital city, and shopping complexes (high‐cost location). Lastly, the type of laser and medical personnel provider can also affect the price of the treatment.
Skin occlusive performance: Sustainable alternatives for petrolatum in skincare formulations
Authors: Pinto Juliana Rodrigues , Monteiro e Silva Silas Arandas , Holsback Valéria de Souza Santos , Leonardi Gislaine Ricci 
Published: January 2022

AbstractBackgroundThe emollients are important ingredients used in skincare formulations that can act as moisturizing agents through their occlusive potential, preventing skin water loss. Consumer interest in natural and sustainable products has grown considerably in the last few years, requiring efforts from the cosmetic industry to design products with raw materials of natural, organic, and sustainable origin. Thus, it is essential to improve the knowledge about the behavior of cosmetic raw materials that can be used as sustainable alternatives to synthetic ingredients.AimThis work aimed to evaluate the occlusive performance of different vegetable oils used as emollients in skincare cosmetics, through comparative analysis with petrolatum, a synthetic emollient with a high occlusive skin potential.MethodThe study included 80 healthy female adult volunteers. TEWL measurements were performed before and after 15 min, 2 and 6 h of emollients application on the forearms of the research participants. All research participants provided written informed consent.ResultsThe results obtained showed that the vegetable oils were effective in providing an occlusive effect on the skin. When compared to the petrolatum, the vegetable oils did not provide a high immediate skin occlusion effect. However, most of them showed a skin occlusion performance comparable to petrolatum throughout the 6 h time course.ConclusionVegetable oils can be used as a sustainable alternative to synthetic emollients, and they are promising in replacing petrolatum in skincare formulations with respect to the occlusion effect of the skin. The vegetable oils did not provide a high immediate skin occlusion effect (15 min post‐application) as the petrolatum, which is known to have increased occlusion properties. However, most of them showed a skin occlusion performance comparable to petrolatum throughout the 6‐hour time course.
Liquidity Fluctuations in Over‐the‐Counter Markets
Authors: MAURIN VINCENT 
Published: January 2022

ABSTRACTThis paper proposes a theory of excess price fluctuations in over‐the‐counter secondary markets. When heterogeneous assets trade under asymmetric information, a quality effect emerges: high liquidity lowers the quality of the pool of sellers and decreases future liquidity. Cyclical equilibria can arise even without fundamental shocks. In a cycle, investors speculate by bidding up the price of low‐quality assets, anticipating a high resale price at the peak. When this resale effect is strong, cycles disappear and multiple steady states coexist with different levels of liquidity. The model rationalizes empirical patterns for corporate bonds and housing in particular.
Paediatric asthma education: Implementation of video‐based education for families
Authors: Frydenberg Alexis , Oborne Naomi , Polley Clare , Littlejohn Emily , Gray Amy 
Published: January 2022

AimTo understand the impact of an asthma education video resource introduced to the short stay unit (SSU) of a tertiary paediatric hospital on: (i) parental understanding of and confidence in managing their child's asthma; (ii) the impact of this resource on nurse‐led education practices; and (iii) readmission rates.MethodsA mixed methods study was conducted in the SSU over an 18‐month period using quantitative survey data from parents and nursing staff and qualitative data from nursing staff focus groups.ResultsOf 117 parents surveyed, 94% reported an increase in their understanding of asthma. Following the introduction of the resource, there were fewer nurse‐led education sessions delivered (1.91 vs. 1.54, P = 0.04) and a trend towards reduction in time spent delivering this education (27.24 vs. 24.98 min, P = 0.47). Nursing staff confidence in the family's understanding of asthma education was similar pre‐ and post‐implementation (4.22 vs. 4.30, P = 0.97). Readmission rates dropped by 25% (readmissions within 1 month) and by 33.3% (readmission within a week) in the post‐intervention cohort.ConclusionsOur asthma education video resource was demonstrated to be an acceptable and effective way of delivering asthma education to families. It created efficiency and consistency for nursing education and practice in our SSU. This resource was viewed by nursing staff as a useful adjunct to their education, enabling consistent messaging and helping structure education delivery. It has been incorporated into hospital systems and national resources which we hope will translate to a reduction in burden of asthma across the community.
Impaired dental implant osseointegration in rat with streptozotocin‐induced diabetes
Authors: Saito Natsumi , Mikami Risako , Mizutani Koji , Takeda Kohei , Kominato Hiromi , Kido Daisuke , Ikeda Yuichi , Buranasin Prima , Nakagawa Keita , Takemura Shu , Ueno Takeshi , Hosaka Keiichi , Hanawa Takao , Shinomura Tamayuki , Iwata Takanori 
Published: January 2022

AbstractObjectiveFew studies have reported on the impact of oxidative stress on the dental implant failure. The aim of this study was to investigate the impact of hyperglycemia‐induced oxidative stress on dental implant osseointegration in diabetes mellitus (DM).MethodsAcid‐treated titanium implants were bilaterally placed in the maxillary alveolar ridge of streptozotocin‐induced diabetic (DM group) and control rats after extraction of first molars. Histological analysis and micro‐push‐out test were performed 4 weeks after surgery. Oxidative stress and osteogenic markers in the surrounding bone were quantified by real‐time polymerase chain reaction. In the in vitro study, rat bone marrow‐derived mesenchymal stem cells (BMMSCs) were cultured on acid‐treated titanium discs in a high‐glucose (HG) or normal environment. Intracellular reactive oxygen species (ROS), cell proliferation, alkaline phosphatase (ALP) activity, and extracellular calcification were evaluated following antioxidant treatment with N‐acetyl‐L‐cysteine (NAC).ResultsThe implant survival rate was 92.9% and 75.0% in control and DM group, respectively. Bone‐implant contact and push‐out loads were significantly lower in the DM group. Expression of superoxide dismutase 1 at the mRNA level and on immunohistochemistry was significantly lower in the DM group. In vitro experiments revealed that the HG condition significantly increased ROS expression and suppressed the proliferation and extracellular calcification of BMMSCs, while NAC treatment significantly restored ROS expression, cell proliferation, and calcification. The ALP activity of both groups was not significantly different.ConclusionIn diabetes, high‐glucose‐induced oxidative stress downregulates proliferation and calcification of BMMSCs, impairing osseointegration and leading to implant failure.
Semaphorin 3A attenuates the hypoxia suppression of osteogenesis in periodontal ligament stem cells
Authors: Chang Xiaochi , Zhou Fengyi , Bu Lingxue , Wang Nan , Deng Jing , Wang Shuai 
Published: January 2022

AbstractObjective and BackgroundThe occurrence and development of periodontitis are closely related to hypoxia of the periodontal microenvironment. Periodontal ligament stem cells (PDLSCs) are considered to have potential to regenerate periodontal tissues. Semaphorin 3A (Sema3A) plays an essential role in promoting osteogenesis. However, the effect of Sema3A on osteogenesis of PDLSCs under hypoxia remains unclear. The aim of this study was to investigate the effect of Sema3A on osteogenesis of PDLSCs under hypoxia.MethodsIsolated PDLSCs were identified using flow cytometry. Adipogenic differentiation potential was identified by oil red O staining. Osteogenesis was measured using Alizarin Red S staining and ALP staining. Intracellular hypoxia was induced using cobalt chloride (CoCl2). The expression level of hypoxia‐inducible factor‐1α (HIF‐1α) was detected via ELISA. Expression of osteogenic markers and Sema3A was analyzed using western blot and real‐time PCR.ResultsThe proliferation and osteogenesis of PDLSCs were markedly inhibited with increased concentrations of CoCl2. Under the treatment with a low concentration of CoCl2, expression of related osteogenic markers and Sema3A decreased in a time‐dependent manner. ARS and ALP staining results also showed that osteogenic calcification decreased under hypoxia. Apigenin, an inhibitor of HIF‐1α, effectively up‐regulated expression of Sema3A and osteogenic markers with CoCl2 treatment. Moreover, exogenous Sema3A significantly increased the expression of osteogenesis‐related markers and mineralization of PDLSCs according to ALP and ARS staining with CoCl2 treatment.ConclusionsHypoxia markedly inhibited osteogenesis of PDLSCs. Sema3A explicitly attenuated the hypoxia suppression of osteogenesis in PDLSCs.
Viral Entanglements: Bodies, Belonging and Truth‐claims in Health Borderlands
Authors: Kasstan Ben 
Published: January 2022

AbstractThis article contributes to anthropological debates surrounding borderlands and biosecurity by tracing the multiple pursuits of protection that emerge between the state and minorities during infectious disease outbreaks. Drawing on an ethnographic study of child health in Jerusalem following epidemics of measles and COVID‐19, the article demonstrates how responses to public health interventions are less about compliance or indiscipline than a competing pursuit of immunity to preserve religious lifeworlds. The voices of Orthodox Jews are situated alongside printed broadsides that circulated anonymous truth‐claims in Jerusalem neighborhoods. These broadsides cast state intervention against historical narratives of deception and ethical failures. Borderland tensions, like a virus, mutate and influence responses to authority and biosecurity, and they reconfigure vernacular entanglements of religion, state, and health. The article encourages anthropologists to consider responses to public health interventions and non‐vaccination beyond a COVID‐19 silo, as part of situated relations between states and minority populations.
Signatures of natural selection in a foundation tree along Mediterranean climatic gradients
Authors: Filipe João Carlos , Rymer Paul D. , Byrne Margaret , Hardy Giles , Mazanec Richard , Ahrens Collin W. 
Published: January 2022

AbstractTemperature and precipitation regimes are rapidly changing, resulting in forest dieback and extinction events, particularly in Mediterranean‐type climates (MTC). Forest management that enhance forests’ resilience is urgently required, however adaptation to climates in heterogeneous landscapes with multiple selection pressures is complex. For widespread trees in MTC we hypothesized that: patterns of local adaptation are associated with climate; precipitation is a stronger factor of adaptation than temperature; functionally related genes show similar signatures of adaptation; and adaptive variants are independently sorting across the landscape. We sampled 28 populations across the geographic distribution of Eucalyptus marginata (jarrah), in South‐west Western Australia, and obtained 13,534 independent single nucleotide polymorphic (SNP) markers across the genome. Three genotype‐association analyses that employ different ways of correcting population structure were used to identify putatively adapted SNPs associated with independent climate variables. While overall levels of population differentiation were low (FST = 0.04), environmental association analyses found a total of 2336 unique SNPs associated with temperature and precipitation variables, with 1440 SNPs annotated to genic regions. Considerable allelic turnover was identified for SNPs associated with temperature seasonality and mean precipitation of the warmest quarter, suggesting that both temperature and precipitation are important factors in adaptation. SNPs with similar gene functions had analogous allelic turnover along climate gradients, while SNPs among temperature and precipitation variables had uncorrelated patterns of adaptation. These contrasting patterns provide evidence that there may be standing genomic variation adapted to current climate gradients, providing the basis for adaptive management strategies to bolster forest resilience in the future.
Effect of phosphodiesterase‐4 inhibitor rolipram on colonic hypermotility in water avoidance stress rat model
Authors: Yuan FangTing , Ren HaiXia , Tan Wei , Wang Ying , Luo HeSheng 
Published: January 2022

AbstractBackgroundPhosphodiesterase (PDE) inhibition has been reported to play a role in regulating gut motility, but the evidence is insufficient, and the mechanism remains unknown. The aim of this study was to investigate the possible role of phosphodiesterase‐4 (PDE4) inhibitor rolipram in water avoidance stress‐induced colonic hypermotility.MethodsA rat model of irritable bowel syndrome (IBS) with diarrhea (IBS‐D) was established by water avoidance stress (WAS). Intestinal motility was assessed by fecal pellets expulsion per hour. The cyclic adenosine monophosphate (cAMP) and nitric oxide (NO) level in colon tissue were detected using ELISA assay and the Griess test, respectively. Western blotting was performed to assess the protein level of PDE, PKA/p‐CREB, and neuronal nitric oxide synthase (nNOS) in the colon. To determine the role of rolipram in gut motility, the rats of the WAS + Rolipram and Rolipram group were injected with rolipram intraperitoneally. The colonic contractile activity was recorded with a RM6240 multichannel physiological signal system.Key Results: WAS‐induced gastrointestinal hypermotility and increased defecation in rats. After repeated stress, protein levels of PDE4 in the colon were promoted while PKA/p‐CREB and nNOS were highly decreased. cAMP content in colon tissue did not change significantly. However, NO content decreased after WAS, and rolipram partly enhanced NO in WAS‐exposed rats. In addition, intraperitoneal injection of rolipram partly inhibited the colonic motility in vivo. Meanwhile, we observed rolipram inhibited the contraction of colonic smooth muscle strips, and this inhibitory effect was abolished by Nω‐Nitro‐L‐arginine (L‐NNA), a nitric oxide synthase (NOS) inhibitor, tetrodotoxin (TTX), a blocker of neuronal voltage‐dependent Na+ channels, Rp‐Adenosine 3’,5'‐cyclic monophosphorothioate triethylammonium salt hydrate (Rp‐cAMPS), an antagonist of cAMP.Conclusions and Inferences: Rolipram could relieve stress‐induced gastrointestinal hypermotility. This effect may be partly through the cAMP‐PKA‐p‐CREB pathway and NO pathway.
Mucoepidermoid carcinoma with metaplastic bone formation—A deceptive radiological presentation
Authors: Nel Chané , Robinson Liam , van Heerden Willie F. P. 
Published: January 2022

AbstractMucoepidermoid carcinoma (MEC) is one of the most common primary salivary gland malignancies in both children and adults. MECs containing calcifications are rare, but well described in the literature. In contrast, there are only two case reports of MECs showing intra‐tumoural bone formation. MECs associated with calcifications occur more frequently in minor salivary glands, compared to bone formation, which is more commonly seen in major glands. This possibly points to a different pathogenic mechanism. Calcifications of the head and neck region are generally diagnosed on conventional imaging by combining the anatomical location with the pattern of calcification. The radiological findings of MECs containing calcifications or bone formation may mimic benign inflammatory processes such as sialoliths. The purpose of this paper is to report three additional cases of MEC containing metaplastic bone formation. These cases presented as painless swellings with radiological signs that could easily be mistaken for dystrophic calcifications. The clinical relevance of the paper is to make clinicians aware of the deceptive radiological appearance of this entity.
The molecular basis of zinc homeostasis in cereals
Authors: Amini Sahand , Arsova Borjana , Hanikenne Marc 
Published: January 2022

AbstractPlants require zinc (Zn) as an essential cofactor for diverse molecular, cellular and physiological functions. Zn is crucial for crop yield, but is one of the most limiting micronutrients in soils. Grasses like rice, wheat, maize and barley are crucial sources of food and nutrients for humans. Zn deficiency in these species therefore not only reduces annual yield but also directly results in Zn malnutrition of more than two billion people in the world. There has been good progress in understanding Zn homeostasis and Zn deficiency mechanisms in plants. However, our current knowledge of monocots, including grasses, remains insufficient. In this review, we provide a summary of our knowledge of molecular Zn homeostasis mechanisms in monocots, with a focus on important cereal crops. We additionally highlight divergences in Zn homeostasis of monocots and the dicot model Arabidopsis thaliana, as well as important gaps in our knowledge that need to be addressed in future research on Zn homeostasis in cereal monocots.