bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency, Causes and Findings of Brain Computed Tomography Scan at University of Lahore Teaching Hospital
Authors: Akhtar Hadia , Yousaf Farooq Syed Muhammad , Shan Ali , Naeem Muhammad , Azhar Ayesha , Sajid Dar Sawaira , Fayyaz Zainab , Amjad Esha , Fatima Arooj , Muhammad Noor Hafsa 
Published: September 2022

Cranial computed tomography (CT) is the most generally utilized diagnostic method for the emergent evaluation of head trauma (TBIs) because it is readily accessible, quick, and sensitive for clinically relevant traumatic brain injuries as well as non-traumatic abnormalities. Objective: To determine the frequency, causes, and findings of brain computed tomography scan at The University of Lahore teaching hospital. Methods: A descriptive study was conducted at The University of Lahore Teaching Hospital. A sample of 202 brain CT scans from a total of 933 participants seen in the CT department was obtained using a suitable sampling technique. Data analysis was done using SPSS version 21.0. Results: There were 78 (38.6%) female patients and 124 (61.4%) male patients out of 202 total patients. The mean age of the patients was 47.1± 23 years. The most prevalent of them, brain atrophy, was observed in 63 (31.2%) of the patients. 51 (25.2%) patients had infarction, 36 (17.8%) had sinusitis, 24 (11.9%) had ischemic demyelination, and 16 (7.9%) had fractures and hemorrhages. In 8 (4.0%) patients, mastoiditis, tumors, and carcinoma were reported. 7 patients (3.5%) had cysts, 6 patients (3.0%) reported contusions, and 2 patients (1.0%) had abscesses. Conclusions: According to our research, the vast majority of individuals who underwent CT scans had a history of headache and falls and the most frequent observation in the patients was brain atrophy. Other major findings found were sinusitis and infarction.
Pandangan Denominasi Kristen Mayoritas Terhadap Ellen Gould White
Authors: Djami Hae Feri Dolf , Pelawi Stepanus , Tinenti Max , Sinaga Janes , Sinambela Juita 
Published: September 2022

Berbagai tantangan terus dihadapi oleh Gereja Masehi Advent Hari Ketujuh sebagai gereja nubuatan yang memiliki panggilan untuk memberitakan Injil keselamatan hanya didalam Tuhan Yesus dan berita kedatangan-Nya yang kedua kali. Salah satunya adalah mencari-cari alasan untuk menolak Ellen G White yang menerima karunia nubuatan, yang mendampingi gereja-Nya untuk membawa semua orang kepada Kristus dan kebenaran-Nya yang berdasarkan kepada Alkitab. Atas dasar itu maka diantara kalangan Kristen mayoritas sedang membangun interpretasi dan mencari alasan dari Alkiab untuk menolak kehadiran dan pelayanan Ellen G. White tanpa mengkorfirmasi dan menguji isi ajaran Ellen G. White lagi. Salah satu ayat yang telah salah ditafsirkan adalah makna dalam surat Ibrani 1:1, 3. Prespektif ini menghasilkan fanatisme yang berlebihan terhadap pelayanan Ellen G. White. Jadi ada kesalahpahaman dalam hal ini karena beberapa kalangan telah menuduh bahwa Alkitab yang telah di kanonisasikan dan sempurna sehingga tidak membutuhkan penambahan atau dianggap belum lengkap. Tuduhan dan salah paham yang dipopulerkan atau dilontarkan adalah tulisan-tulisan Ellen G. White datang untuk menlengkapi isi Alkitab yang sudah dikanonisasikan. Namun sesungguhnya tidak demikian, karena Ellen G. White menegaskan bahwa tulisannya adalah hanya, “terang kecil yang membawa kepada terang yang besar” yaitu Alkitab. Dengan demikian isi penelitian ini menghadirkan studi literatur dengan menggunakan metode kualitatif, yang mengangkat permasalahan tersebut agar mendapatkan keseimbangan informasi dengan tujuan meluruskan pandangan yang tidak sesuai dengan Alkitab.
TUTELA JURÍDICA INTERNACIONAL DO MEIO AMBIENTE: CRISE CLIMÁTICA E A (RE)DEFINIÇÃO DE SUJEITOS E ATORES INTERNACIONAIS
Authors: Sousa Mônica Teresa Costa , Arouche Costa Leite Paulo Victor 
Published: September 2022

O presente artigo propõe uma reflexão sobre atores e sujeitos de Direito Internacional Público a partir da tutela jurídica internacional do meio ambiente. Para tanto, serão abordados aspectos conceituais e históricos do Direito Internacional, e suas mudanças no pós-guerra, com a ascensão dos movimentos ambientalistas como reação à sociedade de risco. O enfraquecimento político dos Estados, a valorização da pessoa humana no plano internacional, e o desenvolvimento do conceito de governança ambiental, como estratégia de enfretamento à crise climática, ocasionou mudanças interpretativas acerca de sujeitos e atores de Direito Internacional. Defendemos que o protagonismo político e econômico dos atores internacionais, bem como surgimento de novos instrumentos e atores, não os qualifica como de sujeitos internacional, qualidade reservada aos Estados e Organizações Internacionais, legitimados pelo conceito de soberania, fundamento do sistema internacional. A metodologia adotada foi a revisão bibliográfica e análise interdisciplinar do objeto.
Ateński filozof i angielski konwertyta wobec oskarżycieli. Obrona Sokratesa Platona i Apologia pro vita sua Johna H. Newmana jako przykłady apologii pro vita sua
Authors: Artemiuk Przemysław 
Published: September 2022

Nowa apologia, ale także współczesna teologia fundamentalna widzi w platońskim dziele matrycę. Sokratesowi chodzi przecież o „niezmienne idee o znaczeniu moralnym”. Dlatego późniejsi apologeci, Justyn, Klemens Aleksandryjski, Orygenes, Augustyn, a w nowszych czasach J.H. Newman i G.K. Chesterton, broniąc własnych racji, wchodząc w spór ze światem, chętnie spoglądali na ateńskiego męża, który pierwszy zdecydował się na apologię pro vita sua, bo wiedział, że są rzeczy nienegocjowalne, których nie może zmienić żaden system polityczny. W prezentowanym artykule autor bada, na czym polega fenomen obrony Sokratesa i dlaczego tak silnie oddziałuje. Próbując znaleźć odpowiedzi na te kwestie, analizuje najpierw dzieło Platona, a potem sięga do dziewiętnastowiecznej Apologia pro vita sua J.H. Newmana, która stanowi w jakiś sposób naśladowanie obrony ateńczyka. Wnioski z analizowanych dzieł przedstawia w perspektywie teologii fundamentalnej.
Biblijne podstawy i historyczny ­rozwój katolickiej nauki o odpustach
Authors: Godlewski Karol Kajetan 
Published: September 2022

Przy współczesnym, niemającym szerszych podstaw teologiczno-dogmatycznych, rozkwicie w Kościele wielu form duchowych praktyk mających na celu uwolnienie człowieka z konsekwencji popełnionych przez niego grzechów i umocnienie go na drodze wierności Ewangelii, szalenie ważną pozostaje kwestia przypominania o sakramentalium, które stanowią odpusty. Nie są one niezrozumiałym reliktem przeszłości ani jedynie pobożną praktyką ludową, ale solidnie umocowaną w tradycji i teologii formą sięgania po zbawcze owoce Paschy Chrystusa. Ich skuteczność w osobie spełniającej znamiona dyspozycyjności do uzyskania odpustu jest gwarantowana autorytetem złożonej w dłoniach Papieża władzy „związywania i rozwiązywania” (por. Mt 16). Wykazane to zostało w niniejszym artykule, na który składają się trzy rozdziały: Pojęcie odpustu, Biblijne uwarunkowania odpustów oraz Historia teologii odpustów.
Chrystologiczna orientacja kultu maryjnego według św. Jana Pawła II
Authors: Wojtczak Adam 
Published: September 2022

Pontyfikat Jana Pawła II cechuje nauczanie maryjne bogate nie tylko w doktrynę, lecz także inspirujące z kultycznego punktu widzenia. Papieską domeną jest troska o chrystologiczną orientację pobożności maryjnej. W setną rocznicę urodzin papieża artykuł przybliża dlaczego chrystocentryzm przynależy do natury kultu maryjnego i w czym konkretnie się on przejawia. Zagadnienia te wyznaczają jego podstawową strukturę. Najpierw dochodzi do głosu formuła „Przez Jezusa do Maryi”, która równoważy tradycyjną formułę „Przez Maryję do Jezusa”. W kolejnym punkcie jest mowa o kontemplacji oblicza Chrystusa w „szkole” Maryi (Eucharystia i różaniec). Dla chrystologicznej odnowy pobożności maryjnej przydatny jest również model pośrednictwa maryjnego w Chrystusie (Maria in Christo Mediatrix), które jest macierzyńskie i podporządkowane Jego pośrednictwu. Papież Wojtyła jest ponadto świadkiem i nauczycielem synowskiego zawierzenia Maryi, które swe źródło ma w Chrystusie i do Niego ostatecznie prowadzi. Pożyteczne jest w końcu papieskie cum, które wyraża, że podążamy do Chrystusa nie tylko „za wzorem” Maryi, ale także „z” Maryją. Przewodnia rola w tym względzie przysługuje encyklikom Redemptoris Mater i Ecclesia de Eucharistia, listowi apostolskiemu Rosarium Virginis Mariae, katechezom maryjnym, jakie papież wygłosił w latach 1995-1997.
Thyroid Oncocytic (Hürthle Cell) Nodules With Longitudinal Nuclear Grooves: Clinicopathologic, Immunohistochemical, and Molecular Genetic Study of 15 Cases
Authors: Suster David , Mackinnon Alexander Craig , Suster Saul 
Published: September 2022

Context.—
Thyroid nodules with longitudinal nuclear grooves have been widely regarded as synonymous with papillary thyroid carcinoma (PTC).

Objective.—
To study a series of cases of thyroid nodules that exhibited oncocytic (Hürthle cell) features and contained longitudinal nuclear grooves yet failed to display aggressive behavior or the full features of papillary thyroid carcinoma.

Design.—
The clinicopathologic, immunohistochemical, and molecular genetic features of 15 patients with these features were studied. Next-generation sequencing was performed to examine 161 genes for oncogenic driver alterations associated with thyroid neoplasia.

Results.—
The lesions occurred in 11 women and 4 men aged 27 to 80 years and measured 0.2 to 2.3 cm in diameter (mean, 1.1 cm). The tumors were well circumscribed and noninvasive and showed a proliferation of large cells with abundant granular cytoplasm and centrally placed nuclei displaying scattered longitudinal nuclear grooves. Immunohistochemical stains were negative for HBME-1, galectin-3, and CK19 in all cases. NRAS pQ61R was detected in 6 cases, KRAS p.Q61E in 1 case, and AKT2 p.E17K in 1 case. None of the genetic changes classically associated with conventional PTC or with high-grade thyroid malignant neoplasms were identified. Clinical follow-up in 9 patients showed no evidence of recurrence or metastases between 2 and 13 years (mean, 5.7 years).

Conclusions.—
Longitudinal nuclear grooves can be occasionally encountered in oncocytic (Hürthle cell) tumors and should not lead to a diagnosis of PTC in the absence of other features supporting that diagnosis.
Genome-wide identification of the trehalose-6-phosphate synthase gene family in sweet orange (Citrus sinensis) and expression analysis in response to phytohormones and abiotic stresses
Authors: Liu Kehong , Zhou Yan 
Published: September 2022

Background
Trehalose-6-phosphate synthase (TPS) is an essential enzyme for synthesizing trehalose and is a significant regulator of plant development and stress response. Sweet orange (Citrus sinensis) is an economically important fruit tree crop and a common transgenic material. At present, little information is available about the TPS gene family in sweet orange.

Methods
The TPS gene family were identified from sweet orange genome by bioinformatics analysis. Additionally, the expression of CisTPS genes was analyzed under phytohormones and abiotic stresses by quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR).

Results
Here, eight TPS genes were identified and were found to be randomly distributed in five sweet orange chromosomes. TPS and trehalose-6-phosphate phosphatase (TPP) domains were observed in all CisTPS proteins. The phylogenetic tree showed that CisTPS genes were divided into two subfamilies, and genes in each subfamily had conserved intron structures and motif compositions. The cis-acting elements of CisTPS genes suggested their roles in phytohormone and stress responses. All CisTPS genes were ubiquitously expressed in roots, leaves, and stems, and six members were highly expressed in roots. Expression profiles showed that CisTPS genes exhibited tissue specificity and were differentially expressed in response to phytohormones and abiotic stresses. This study lays a foundation for revealing the functions of the TPS gene family in trehalose regulation in sweet orange, and provides a valuable reference for this gene family in other plants.
Ecological Risk Assessment of Oil Spill Events Using a Coupled Geospatial and Weight of Evidence Data-Process Model
Authors: Mbaoma Oliver Chinonso , Edjere Oghenekohwiroro , Akinpelu Peculiar , Shittu Ridwan Adeyemi , Serian Onadipe 
Published: September 2022

This research work applied geospatial and weight of evidence approach to ecological risk assessment for quantifying environmental exposure to oil pollution in the Niger Delta. Spatial data for Pipelines, Oil spills and Land Cover were used to quantify the extent of Ecological resources exposed to oil pollution using a data-process model. Regional scale risk assessment was done using the combination of geospatial and statistical approaches. Hotspot and Proximity analysis were used for geospatial analysis while weight of evidence was adopted for statistical computation. Ecological resources were identified from land cover maps and ranked according to their perceived importance. Hotspots of oil spill incidents were determined using spatial autocorrelation. Ecological resource vulnerability was determined using buffer zoning of 5 km and 10 km respectively as high and low risk zones, with sample maps made to show extents of resources at risk. Areal extent of ecological resources at risk were calculated and standardized for each of the delineated buffer zones. An aggregate of the weight of each ecological resources and area was computed to categorize the risk as either high, medium or low. This study has successfully assembled and produced relevant spatial and attribute data sets and applied integrated geostatistical analytical techniques to understand the distribution and impacts of oil spills in the Niger Delta. The procedure was seen as an alternative to existing management processes used for monitoring and management of oil spill events.
Effect of Manure and Fertilizers on Growth and Yield of Pipali (Piper longum) in Assam Conditions
Authors: Saud Bijit Kr. , Kaman Pranjal Kr. 
Published: September 2022

An experiment was conducted in the Experimental Farm Garden, at Assam Agricultural University, Jorhat to see the influence of manure and fertilizers on growth and yield of Pipali (Piper longum) in Assam conditions. Result revealed that maximum yield (576.25kg/ha dry) was obtained when manure and fertilizers was applied @ 175:75:75 kg ha-1(NPK) + FYM 10 ha-1 + Neem cake 5q ha-1 and minimum yield of (318.67 Kg/ha dry) when only manure @ FYM 10 ha-1 was applied in field. Hence, we conclude that the long pepper is an organic matter and fertilizer loving crop and application of higher levels of organic manures and fertilizers improved both plant and soil nutrient status.
Effect of Phosphorus and Sulphur Levels on Growth, Nodulation and Yield of Soybean [Glycine max (L.) Merrill] in South-Eastern Part of Rajasthan
Authors: Manoj . , Sharma M. K. , Meena Harphool , Yadav Rajendra K. , Yadav Vinod K. , Danga Sangeeta , Ghasil Bahnu Pratap , Yadav Pinky , Prakash Gaurav 
Published: September 2022

An experiment was conducted at Instructional Farm, College of Agriculture, Ummedganj, Kota during kharif, 2021. The twelve treatment combinations comprised of four levels of phosphorus viz., 0, 20, 40 and 60 kg ha-1 allocated in main plots and three levels of sulphur viz., 15, 30 and 45 kg ha-1 in sub plots. Results showed that application of 60 kg P2O5 ha-1 had significant effect on plant height at 60 DAS and at harvest, number of total root nodules plant-1, effective root nodules plant-1 and dry weight of root nodules at 45 DAS, chlorophyll content at 45 DAS and leaf area index at 50 DAS of soybean over application of 20 kg P2O5 ha-1 and control but it was found at par with 40 kg P2O5 ha-1. The maximum seed yield (1942 kg ha-1) and straw (3305 kg ha-1) yield of soybean were recorded under application of 60 kg P2O5 ha-1 over application of 20 kg P2O5 ha-1 and control but it was found at par with 40 kg P2O5 ha-1. Significantly higher plant height at 60 DAS and at harvest, number of total root nodules plant-1, effective root nodules plant-1 and their dry weight at 45 DAS, chlorophyll content at 45 DAS, leaf area index at 50 DAS, seed yield (1870 kg ha-1) and straw yield (3179 kg ha-1) of soybean were recorded under application of 45 kg sulphur ha-1 which was found at par with 30 kg sulphur ha-1 and both these sulphur levels gave significant increase over application of 15 kg sulphur ha-1.
Optical Coherence Tomography Guidance in Management of Complex Lesions Intervention
Authors: El-Harty Sameh Mohammed , Trani Carlo , El-Seteiha Mohamed El-Saied , Salama M. Mai , Badr Seham Fahmy , El-Masry Magdy Mohamed 
Published: September 2022

Background: Optical Coherence Tomography (OCT) can identify tissue characters depending on the polarisation properties of light, allowing detailed investigation of plaque form, content, and distribution. Calcification strongly correlates with advanced atherosclerosis, increased age, and comorbidities. The presence of calcified and hard lesions makes percutaneous coronary intervention (PCI) difficult and frequently needs adjunctive procedures to get excellent stent outcomes. The purpose of this research was to assess the role of OCT, and how it affects the operator decision in management and optimizing of PCI for complex coronary lesions, including left main and non-left main bifurcation lesions, calcific lesions and in stent restenosis.
Methods: This prospective observational single center research was carried out on 60 patients underwent elective PCI for complex coronary lesions. Cases were classified into two groups based on the change in the operator opinion after performing OCT, either before or after stenting. Group I (n=19) patients with no change in operator decision based on OCT. Group II (n=41) patients with change in operator decision based on OCT. All patients were subjected to Clinical examination, Twelve leads surface electrocardiogram (ECG), Echocardiography, diagnostic coronary angiography.
Results: Among the 60 cases involved in the research, the decision of the operator was changes in 41 patients (68%). The change based on the pre-PCI assessment was found in 21 patients (51% of all changes). The changes were either change in the number of stents, the technique of the bifurcation intervention, or the need of atherectomy devices in calcific lesion for good lesion preparation. The change in the decision based on pots-PCI OCT only was found in 10 patients (41% of all changes). The main change of the procedure based on post-PCI OCT was mainly further post dilatation due to malapposition or significant tissue protrusion, or implantation of another stent for distal edge dissection.
Conclusion: OCT is a very helpful intravascular imaging for optimization of PCI for complex coronary lesion. It significantly changed the decision of the operator for the aim of optimal stent apposition and to reduce complications in complex lesions.
Measurement of the temporal latency of a respiratory gating system using two distinct approaches
Authors: Stock Michael G. , Chu Connel , Fontenot Jonas D. 
Published: September 2022

AbstractPurposeTo develop a methodology that can be used to measure the temporal latency of a respiratory gating system.MethodsThe gating system was composed of an automatic gating interface (Response) and an in‐house respiratory motion monitoring system featuring an optically tracked surface marker. Two approaches were used to measure gating latencies. A modular approach involved measuring separately the latency of the gating system's complementary metal–oxide–semiconductor tracking camera, tracking software, and a gating latency of the LINAC. Additionally, an end‐to‐end approach was used to measure the total latency of the gating system. End‐to‐end latencies were measured using the displacement of a radiographic target moving at known velocities during the gating process.ResultsSumming together the latencies of each of the modular components investigated yielded a total beam‐on latency of 1.55 s and a total beam‐off latency of 0.49 s. End‐to‐end beam‐on and beam‐off latency was found to be 1.49 and 0.34 s, respectively. In each case, no statistically significant differences were found between the end‐to‐end latency of the gating system and the summation of the individually measured components.ConclusionTwo distinct approaches to quantify gating latencies were presented. Measuring the end‐to‐end latency of the gating system provided an independent means of validating the modular approach. It is expected that the beam‐on latencies reported in this work could be reduced by altering the control system configuration of the LINAC. The modular approach can be used to decouple the individual latencies of the gating system, but future improvements in the temporal resolution of the service graphing feature are needed to reduce the uncertainty of LINAC‐related gating latencies measured using this approach. Both approaches are generalizable and can be used together when designing a quality assurance program for a respiratory gating system.
Effects of PB‐TURSO on the transcriptional and metabolic landscape of sporadic ALS fibroblasts
Authors: Fels Jasmine A. , Dash Jalia , Leslie Kent , Manfredi Giovanni , Kawamata Hibiki 
Published: September 2022

AbstractObjectiveALS is a rapidly progressive, fatal disorder caused by motor neuron degeneration, for which there is a great unmet therapeutic need. AMX0035, a combination of sodium phenylbutyrate (PB) and taurursodiol (TUDCA, TURSO), has shown promising results in early ALS clinical trials, but its mechanisms of action remain to be elucidated. Therefore, our goal was to obtain an unbiased landscape of the molecular effects of AMX0035 in ALS patient‐derived cells.MethodsWe investigated the transcriptomic and metabolomic profiles of primary skin fibroblasts from sporadic ALS patients and healthy controls (n = 12/group) treated with PB, TUDCA, or PB–TUDCA combination (Combo). Data were evaluated with multiple approaches including differential gene expression and metabolite abundance, Gene Ontology and metabolic pathway analysis, weighted gene co‐expression correlation analysis (WGCNA), and combined multiomics integrated analysis.ResultsCombo changed many more genes and metabolites than either PB or TUDCA individually. Most changes were unique to Combo and affected the expression of genes involved in nucleocytoplasmic transport, unfolded protein response, mitochondrial function, RNA metabolism, and innate immunity. WGCNA showed significant correlations between ALS gene expression modules and clinical parameters that were abolished by Combo treatment.InterpretationThis study is the first to explore the molecular effects of Combo in ALS patient‐derived cells. It shows that Combo has a greater and distinct impact compared with the individual compounds and provides clues to drug targets and mechanisms of action, which may underlie the benefits of this investigational drug combination.
What should we tell patients about the privacy of Their SUD records?
Authors: Stauffer William 
Published: September 2022

What do we tell clients about the privacy of their records? This is now harder to answer than ever before. There have been many changes to federal SUD privacy laws in recent years. We no longer can say with reliability that SUD records are private. In some instances, 42 CFR Part 2 (or simply Part II) records now only require initial consent. Information just flows out from there in compliance with the weaker HIPAA standard, which saw a 300% increase in data hacking or breaches (50 million Americans) in 2021. Providers are also largely unaware of their own liability when such breaches occur downstream from them as information flows out into the medical data river.