bluuebunny/crossref_metadata_2025_split huggingface dataset:
Positive parenting, adolescent adjustment, and quality of adolescent diet in nine countries
Authors: Zietz Susannah , Cheng Emily , Lansford Jennifer E. , Deater‐Deckard Kirby , Di Giunta Laura , Dodge Kenneth A. , Gurdal Sevtap , Liu Qin , Long Qian , Oburu Paul , Pastorelli Concetta , Skinner Ann T. , Sorbring Emma , Steinberg Laurence , Tapanya Sombat , Tirado Liliana Maria Uribe , Yotanyamaneewong Saengduean , Alampay Liane Peña , Al‐Hassan Suha M. , Bacchini Dario , Chang Lei , Bornstein Marc H. 
Published: September 2022

AbstractIntroductionWe sought to understand the relation between positive parenting and adolescent diet, whether adolescents' internalizing and externalizing behaviors mediate relations between positive parenting and adolescent diet, and whether the same associations hold for both boys and girls and across cultural groups.MethodsAdolescents (N = 1334) in 12 cultural groups in nine countries were followed longitudinally from age 12 to 15. We estimated two sets of multiple group structural equation models, one by gender and one by cultural group.ResultsModeling by gender, our findings suggest a direct effect of positive parenting at age 12 on a higher quality diet at age 15 for males (β = .140; 95% CI: 0.057, 0.229), but an indirect effect of positive parenting at age 12 on a higher quality diet at age 15 by decreasing externalizing behaviors at age 14 for females (β = .011; 95% CI: 0.002, 0.029). Modeling by cultural group, we found no significant direct effect of positive parenting at age 12 on the quality of adolescent diet at age 15. There was a significant negative effect of positive parenting at age 12 on internalizing (β = −.065; 95% CI: −0.119, −0.009) and externalizing at age 14 (β = −.033; 95% CI: −0.086, −0.018).ConclusionsWe founder gender differences in the relations among positive parenting, adolescents' externalizing and internalizing behaviors, and adolescent diet. Our findings indicate that quality of parenting is important not only in promoting adolescent mental health but potentially also in promoting the quality of adolescents' diet.
Vascular elasticity measurement of the great saphenous vein based on optical coherence elastography
Authors: Gao Tianxin , Liu Shuai , Wang Ancong , Tang Xiaoying , Fan Yingwei 
Published: September 2022

AbstractVascular elasticity is important in physiological and clinical problems. The mechanical properties of the great saphenous vein (GSV) deserve attention. This research aims to measure the radial elasticity of ex vivo GSV using the optical coherence elasticity (OCE). The finite element model of the phantom is established, the displacement field is calculated, the radial mechanical characteristics of the simulation body are obtained. Furthermore, we performed OCE on seven isolated GSVs. The strain field is obtained by combining the relationship between strain and displacement to obtain the radial elastic modulus of GSVs. In the phantom experiment, the strain of the experimental region of interest is mainly between 0.1 and 0.4, while the simulation result is between 0.06 and 0.40. The radial elastic modulus of GSVs ranged from 3.83 kPa to 7.74 kPa. This study verifies the feasibility of the OCE method for measuring the radial elastic modulus of blood vessels.
Material properties of degradable alloyFe–30Mn–0.6Nand its effect on ferroptosis in synoviocytes
Authors: Yang Tianyu , Hao Shimin , Wang Penghao , Qin Yu , You Guanchao , Shi Yunyi , Yang Boning , Zhang Ao , Guo Lei , Jiang Tianlong 
Published: September 2022

AbstractFerroalloy has shown potential as implant materials, but little attention has been paid to their effects on synovial tissue ferroptosis. This study aimed to examine the mechanical properties, degradability and biocompatibility of Fe–30Mn–0.6N alloy and effects of it on synovial tissue ferroptosis. Tensile testing showed that Fe–30Mn–0.6N alloys exhibited tensile strength of 487 ± 18 MPa, yield strength of 221 ± 10 MPa, elongation of 16.9 ± 0.3% and Young's modulus of 37.7 ± 1.3 GPa. In vivo experiments, the cross‐sectional area of the Fe–30Mn–0.6N alloys decreased by 73.32 ± 12.73% after 8 weeks of implantation. The results of scanning electron microscopy (SEM) and surface elemental analysis (EDS) showed that the Fe–30Mn–0.6N alloys had more Ca, O, C and P element deposition (p < .05). After 2, 4 and 8 weeks of implantation, no inflammatory response was observed in peri‐implant synovial tissue of Fe–30Mn–0.6N and Ti–6Al–4V alloys, and Fe–30Mn–0.6N alloys did not affect the expression of the ferroptosis inhibitory gene Glutathione peroxidase 4 (GPX4). Compared with the control group, 30% Fe–30Mn–0.6N alloy extracts did not affect the cell viability (p > .05) in vitro, and intracellular Fe2+and the reactive oxygen species (ROS) was significantly reduced (p < .05). WB and PCR results showed that the 30% extracts increased the protein activity and mRNA expression of GPX4, FTH1 and SLC7A11 in synoviocytes, but had no effect on PTGS2 and p53. It is concluded that Fe–30Mn–0.6N had degradability and biocompatibility in peri‐implant synovial tissue, and did not induce significantly ferroptosis in synoviocytes.
Targeting bacterial biofilms using vancomycin and multivalent cell‐penetrating peptide labeled quantum dots
Authors: Kumar Munish , Pandey Satish Kumar , Lalhall Alisha , Sharma Rohit , Sharma Rohit K. , Wangoo Nishima 
Published: September 2022

AbstractBacterial biofilms are highly resilient microbial musters that are difficult to eradicate, driving the development of novel therapeutic strategies. The current study aims to investigate the therapeutic efficacy of cell‐penetrating peptide‐based targeted delivery of vancomycin functionalized quantum dots in eradicating biofilm formation in gram‐positive and gram‐negative bacterial strains. The conjugate was characterized using fluorimetry, UV–visible spectroscopy, gel electrophoresis, and zeta potential. The conjugate was then tested for antimicrobial and antibiofilm activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, and it demonstrated excellent antimicrobial as well as antibiofilm activity against all the tested strains. The findings indicated that the conjugate was capable of overcoming bacterial resistance of bacteria in addition to the eradication of biofilms at effective concentrations.
Epigallocatechin‐3‐gallate (EGCG) attenuates inflammatory responses and oxidative stress in lipopolysaccharide (LPS)‐induced endometritis via silent information regulator transcript‐1 (SIRT1)/nucleotide oligomerization domain (NOD)‐like receptor pyrin domain‐containing 3 (NLRP3) pathway
Authors: Di Man , Zhang Qianfeng , Wang Jingjing , Xiao Xifeng , Huang Jianlei , Ma Yuan , Yang Hongya , Li Mao 
Published: September 2022

AbstractThe protective effects of epigallocatechin‐3‐gallate (EGCG) on lipopolysaccharide (LPS)‐induced endometritis in vivo and in vitro will be explored in this study. The endometritis model was induced in female BALB/c mice uterus by perfusion with lipopolysaccharide (LPS) and EGCG were administered at 1 h before LPS induction. The primary bovine endometrial epithelial cells (BEECs) were treated with EGCG for 1 h before LPS stimulation. Uterine histopathological changes, myeloperoxidase (MPO) activity, inflammatory cytokine levels and oxidative stress markers were determined. The extent of Bax, Bcl‐2, cleaved caspase‐3, silent information regulator transcript‐1 (SIRT1), nucleotide oligomerization domain (NOD)‐like receptor pyrin domain‐containing 3 (NLRP3), apoptosis‐associated speck‐like protein (ASC) and Caspase1 was detected by Western blot and real‐time quantitative PCR assays. The results showed that EGCG significantly reversed the LPS‐induced uterine histopathological changes, MPO activity, pro‐inflammatory cytokine levels. Additionally, EGCG decreased oxidative stress and reduced cell apoptosis by upregulating SIRT1 expression, downregulating the NLRP3 inflammasome activation. These findings indicated that EGCG exerted its greatest protective effects by blocking inflammatory responses, lowering oxidative stress, and reducing apoptosis via the SIRT1/NLRP3, making its promising candidate treatment for endometritis.
Relativistic adapted Gaussian basis sets free of variational prolapse of small and medium size for hydrogen through xenon
Authors: Gusmão Eriosvaldo Florentino , Haiduke Roberto Luiz Andrade 
Published: September 2022

AbstractTwo new relativistic adapted Gaussian basis sets of small and medium size are presented for all elements from Hydrogen through Xenon. These sets are free of variational prolapse and were developed with the polynomial generator coordinate Dirac‐Fock method to be used with two finite nuclear models, uniform sphere and Gaussian. The largest basis set errors for electronic configurations from the Aufbau principle are around 10.0 and 4.7 mHartree for the small– and medium–size sets, respectively, which is in accordance with the accuracy level expected in each case. Hence, to our knowledge, these are the smallest prolapse free basis sets developed for these elements.
DTBP‐promoted Passerini‐type reaction of isocyanides with aldehydes: Synthesis of α‐acyloxycarboxamides
Authors: Wang Zhuo , Zhang Yan , Wu Zi‐Han , Zhao Yu‐Long 
Published: September 2022

AbstractA novel DTBP‐promoted Passerini‐type reaction of isocyanides with two molecular aldehydes has been developed. This reaction is applicable for a wide range of isocyanides and aldehydes and provides an efficient method for the synthesis of α‐acyloxycarboxamides with two identical functional groups in good to high yields in a single step. The experimental results clearly confirmed the role of water and provided a better mechanistic understanding of this reaction.
Dental trainees’ mental health changes, sources of stress, coping strategies, and suggestions for mental health improvement 1 year into the pandemic
Authors: Hill Courtney M. , Moore Eliza , Randall Cameron L. , Chi Donald L. 
Published: September 2022

AbstractObjectivesThe goal of this study was to assess how the mental health of dental trainees has changed during the pandemic and to identify the most stressful aspects of trainees’ programs, stress coping strategies, and suggestions for individual and institution‐driven solutions to improve wellness.MethodsThe study focused on dental trainees at the University of Washington who completed a wellness survey in fall 2020 (n = 126; response rate = 35.5%) and spring 2021 (n = 105; response rate = 29.6%). The survey included self‐report measures assessing four mental health outcomes: depression, anxiety, isolation from peers, and burnout. Stressful aspects of the training program, coping strategies, and institution‐driven solutions were measured with open‐ended survey items. The chi‐square test was used to compare mental health outcome measures between fall and spring and open‐ended survey responses were inductively coded.ResultsThe prevalence of self‐reported depression and anxiety did not change between fall 2020 and spring 2021 (17.2% vs. 21.1%, p = 0.473; 22.4% vs. 23.7%, p = 0.818). Isolation from peers and burnout each significantly increased by almost 20% from fall 2020 to spring 2021 (46.8% vs. 64.3%; p = 0.009 and 26.6% vs. 43.9%; p = 0.017). Trainees identified workload as the most stressful aspect of their program and described using exercise and social support to cope with stress. Trainees suggested institution‐supported increases in social events and mental health resources.ConclusionsOne year into the coronavirus disease 2019 pandemic, poor mental health outcomes were common among dental trainees because of high workload and isolation from peers. Dental schools should promote targeted programs and services aimed at improving dental trainees' well‐being.
Managing relapsed refractory lymphoma with palliative oral chemotherapy: A multicentre retrospective study
Authors: Bulley Simon J. , Santarsieri Anna , Lentell Isabel C. , O'Sullivan Brendan , Hodson Andrew , Firth Oliver , Sadullah Shalal , Follows Annabel M. , Karanth Mamatha , Min Sandra Young , Fowler Alexis , Russell James , Uttenthal Benjamin J. , Hodson Daniel J. , Follows George A. 
Published: September 2022

AbstractPEP‐C (prednisolone, etoposide, procarbazine and cyclophosphamide) is an orally administered daily chemotherapy regimen used with palliative intent in relapsed refractory lymphoma. To our knowledge, no data on PEP‐C have been reported since the original group described the regimen. Here we present a multicentre retrospective cohort reporting our use of PEP‐C in 92 patients over an 8‐year period. We find that even heavily pretreated lymphoma can respond to PEP‐C, particularly low‐grade lymphoma (including mantle cell) and lymphoma that was sensitive to the previous line of systemic therapy (chemosensitive). These characteristics may help in the selection of patients likely to derive benefit. The median overall survival of patients with chemosensitive lymphoma treated with PEP‐C is 217 days. Within the limitations of a retrospective cohort, we find that PEP‐C is well tolerated: the most common toxicity leading to discontinuation is marrow suppression. We suggest that PEP‐C should be considered for patients with relapsed refractory lymphoma in two settings: first, where there is no licensed alternative; and second, where the licensed alternative is an intravenous drug and the patient would prefer to choose an oral chemotherapy option.
Neutralizing monoclonal antibodies for early treatment of hospital‐acquired SARS‐CoV‐2 infection in hematologic patients
Authors: Bussini Linda , Testi Diletta , Tazza Beatrice , Oltolini Chiara , Mastaglio Sara , Sepulcri Chiara , Campoli Caterina , Trapani Filippo , Pasquini Zeno , Zappulo Emanuela , Bassetti Matteo , Viale Pierluigi , Mikulska Malgorzata , Bartoletti Michele 
Published: September 2022

AbstractEfficacy of early treatment with anti‐SARS‐CoV‐2 spike protein monoclonal antibodies (mAbs) for nosocomial SARS‐CoV‐2 infection in hematologic patients is unknown. Retrospective, cohort study conducted in four Italian teaching hospitals. We included adult patients with hematologic malignancies and hospital‐acquired SARS‐CoV‐2 infection diagnosed between November 2020 and December 2021. The principal exposure variable was administration of mAbs. The primary endpoint was clinical failure dea composite outcome of mortality and/or invasive and noninvasive ventilation within 90 days from infection onset. We included 52 patients with hospital‐acquired SARS‐CoV‐2 infection. Males were 29 (60%), median age was 62 (interquartile range [IQR] 48–70). Forty‐five (86%) patients were on chemotherapy or had received chemotherapy within 30 days. MAbs were administered in 19/52 (36%) patients. Clinical failure occurred in 22 (42%) patients; 21% (4/19) in mAbs group versus 54% (18/33) in non‐mAbs group (p = 0.03). Other predictors of clinical failure were older age (median [IQR] 69 [61–72] versus 58 [46–66], p = 0.001), and higher Charlson comorbidity index (median [IQR], 5 [3.25‐5] versus 3 [2–5], p = 0.002). At multivariable Cox regression model, mAbs were independently associated with a significantly lower rate of clinical failure (HR 0.11, 95% CI 0.01–0.85, p = 0.01), after adjusting for confounders. In conclusion, mAbs are promising for early treatment of hematologic patients with healthcare‐related SARS‐CoV‐2 infection.
A germline exome analysis reveals harmful POT1 variants in multiple myeloma patients and families
Authors: Hakkarainen Marja , Koski Jessica R. , Heckman Caroline A. , Anttila Pekka , Silvennoinen Raija , Lievonen Juha , Kilpivaara Outi , Wartiovaara‐Kautto Ulla 
Published: September 2022

AbstractObservations of inherited susceptibility to multiple myeloma have led to active research in defining predisposing genes to the disease. Here, we analysed 128 plasma cell dyscrasia patients’ germline whole‐exome sequencing data. Rare dominantly inherited pathogenic or likely pathogenic (P/LP) variant was found in 9.4% of the patients. Among the P/LP variants, CHEK2 (p. Thr410MetfsTer15) was the most prevalent (n = 5, 3.9%). Interestingly, P/LP variants in POT1 were identified in three patients (2.3%). Our findings broaden the spectrum of POT1‐related cancers and demonstrate the importance of the germline genetic analysis in hematological malignancies.
β‐Galactosidase deficiency in the GLB1 spectrum of lysosomal storage disease can present with severe muscle weakness and atrophy
Authors: Pedersen Jonas Jalili , Duno Morten , Wibrand Flemming , Hammer Christian , Krag Thomas , Vissing John 
Published: September 2022

AbstractDeficiency of the enzyme β‐galactosidase due to variants in the GLB1‐gene is associated with metabolic disorders: Morquio B and GM1‐gangliosidosis. Here, we report a case compound heterozygous for variants in the GLB1‐gene and a severe muscular phenotype. Full body T1‐w MRI was conducted for muscular involvement. Biopsy was stained with hematoxylin and eosin for histopathological evaluation. EDTA blood‐sample was subjected to whole exome sequencing. Metabolic analysis included residual enzyme activity and evaluation urinary substrate secretion. Additionally, electroneurography, echocardiography, forced volume capacity and biochemistry were evaluated. Examination showed severe proximal weakness (MRC: hip flexion 2, hip extension 2, and shoulder rotation 2), Gower's sign, no extrapyramidal symptoms and normal creatine kinase levels. MRI showed severe muscle wasting of the thigh and shoulder girdle. Muscle biopsy showed mild myopathic changes. β‐galactosidase activity was reduced to 28%–34%. Urinary glycosaminoglycan was elevated by 5.9–8.6 mg/mmol (ref.:0–5.1 mg/mmol). Electrophoresis indicated excess keratan sulfate. Exome sequencing revealed two missense variants in the GLB1 gene. Clinical features, genetic testing and laboratory findings indicate a case of β‐galactosidase‐deficiency with a muscular phenotype.
Interactions between the Caspian Sea size (level) and atmospheric circulation
Authors: Molavi‐Arabshahi Mahboubeh , Arpe Klaus 
Published: September 2022

AbstractResults from idealized model simulations (a relationship between Caspian Sea level [CSL] with its change of the Caspian Sea [CS] size and CS surface temperature [SST]) are validated and connections are explained. Energy budgets for CS water using proxy observational data (ERA5) are used, especially for the comparison of 1979 and 1995, the two extreme values of the CSL. In 1995, when CSL reached a maximum, there were many El Niño events. Investigations on the effects of ENSO on the position of the jet stream over the CS had previously been shown. A jet stream requires a region of baroclinicity beneath it, usually associated with precipitation and cloud cover. This leads to an increase in CSL. A possible forcing of El Niño events by the CS size was found in recent idealized model simulations. Evidence of this is also documented here in analysis of observational data. The size of the CS could have an impact on the occurrence of El Niño events that affect atmospheric circulation. There is much evidence of such a relationship in the observed atmosphere. Real proof is extremely difficult to obtain, only one historical event provides further evidence for such a connection.
A high‐performance liquid chromatography method for simultaneous quantification of metformin and ferulic acid in solid dosage forms
Authors: Chaves Júnior José Venâncio , Muniz Vanessa Morais , de Almeida Vinícius Cleithon Rodrigues , de Souza Fábio Santos , Aragão Cícero Flávio Soares 
Published: September 2022

Metformin is one of the most commonly used drugs in the world for the treatment of type 2 diabetes, while ferulic acid is a molecule that stands out for its antioxidant potential. Recent studies demonstrate hypoglycemic synergy between these molecules. The objective of this study is to develop and validate an analytical methodology by high‐performance liquid chromatography for the simultaneous quantification of these drugs in pharmaceutical formulations. The method used an octadecylsilane column and a mobile phase composed of 6 mM sodium lauryl sulfate in 15 mM phosphate buffer:ACN (65:35). Ferulic acid and metformin were monitored at 232 nm, with a mobile phase flow rate of 1 ml/min and oven temperature at 40°C. The method was linear in the range of 5–25 μg/ml for both molecules. In the presence of degradation products, satisfactory selectivity was achieved. Accuracy values were close to 100% and standard deviations in precision were less than 2%. In the robustness evaluation, the proposed variations did not interfere with the quantification. Therefore, it is concluded that the present method can be safely applied to the quality control of ferulic acid and metformin raw materials, as well as when they are combined in pharmaceutical formulations.
Utilization of ionic deep eutectic solvent as sustainable mobile phase additive in high‐performance liquid chromatography for improving the separation of biogenic amines
Authors: He Sile , Choi Dong Min , Row Kyung Ho 
Published: September 2022

Biogenic amines are present in large quantities in fermented foods and are a key marker for assessing food safety. This paper proposes a novel method for high‐performance liquid chromatography analysis of biogenic amines using deep eutectic solvent as a mobile phase additive. After screening eight synthetic deep eutectic solvents and comparing them with several common additives, deep eutectic solvents based on choline chloride and ethylene glycol showed significant effects in improving the separation of biogenic amines. A Box–Behnken design of 17 runs was used to screen and optimize the key chromatographic parameters, resulting in an expected composition of the mobile phase of 0.73% deep eutectic solvent, 65% acetonitrile, and a column temperature of 28°C. The proposed method exhibited excellent linearity (0.1–50 μg/ml, R2 ≥ 0.9987), limit of detection (0.007–0.031 μg/ml), precision (1.28%–5.34%) and accuracy (87.2%–110.6%). The method can be applied successfully to the separation and analysis of biogenic amines in cooking wine samples.
The effect of global volatility, uncertainty and geopolitical risk factors on international tourist arrivals in Asia
Authors: Doğan Buhari , Ghosh Sudeshna , Tiwari Aviral Kumar , Abakah Emmanuel Joel Aikins 
Published: September 2022

AbstractThe major tourist destinations in the Asian region are promoting and maintaining a conducive tourism environment. The susceptibility of the major tourist destinations in Asia to the uncertainties may encumber the arrival of international tourists. However, to the best of our understanding the research in this area is scant. Further though the tourism‐uncertainty nexus has been widely explored in the literature, the deliberations in a time‐varying and frequency‐domain framework continue to be ignored. Thus, building upon the earlier deficiencies this study, investigates in a time and scale varying framework the tourism uncertainty/risk nexus for Singapore and Malaysia, two major tourist destinations in the Asian region. This article endeavors to investigate the role of world policy uncertainty, US Monetary Policy Uncertainty, geopolitical risk, Global Financial Stress Index and market volatility on international tourist arrivals in Malaysia and Singapore. To the best of our understanding, this study is the foremost to scrutinize the interrelatedness between these variables in a multivariate wavelet causality framework, from January 2000 to April 2020. Our results show that the global uncertainties manifested through different macro‐based indicators affect international tourism demand for the destination countries. During the subprime crisis, Euro‐crisis and the pandemics significant coherencies are perceptible. The major empirical findings of the impact of uncertainty indicators and geopolitical risk on international tourist arrivals over the recent period have important implications for policy makers and practitioners.