bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between social jetlag and parameters of metabolic syndrome and type 2 diabetes: a systematic review and meta‐analysis
Authors: Bouman Emma J. , Beulens Joline W. J. , Groeneveld Lenka , de Kruijk Rozemarijn S. , Schoonmade Linda J. , Remmelzwaal Sharon , Elders Petra J. M. , Rutters Femke 
Published: November 2022

SummaryThis study aims to determine the association between social jetlag and parameters of metabolic syndrome and type 2 diabetes (T2D) in a systematic review and meta‐analysis. A systematic literature search was conducted in PubMed/Embase/Scopus until May 2022. Included studies described an association between social jetlag and parameters of the metabolic syndrome and/or T2D, were available full text and written in English or Dutch. Data extraction and quality assessment were performed on pre‐piloted forms independently by two reviewers. Results were meta‐analysed using random‐effects analysis. A total of 6,290 titles/abstracts were screened, 176 papers were read full‐text, 68 studies were included. Three studies were rated as low quality, 27 were moderate, and 38 were high quality. High quality studies showed that having social jetlag compared to no social jetlag was significantly associated with higher body mass index in 20 studies (0.49 kg/m2, 95% confidence interval [CI] 0.21–0.77; I2 = 100%), higher waist circumference in seven studies (1.11 cm, 95% CI 0.42–1.80; I2 = 25%), higher systolic blood pressure in 10 studies (0.37 mmHg, 95% CI 0.00–0.74; I2 = 94%) and higher glycated haemoglobin in 12 studies (0.42%, 95% CI 0.12– 0.72; I2 = 100%). No statistically significant associations were found for obesity, abdominal obesity, high‐ and low‐density lipoprotein levels, cholesterol, triglycerides, diastolic blood pressure, hypertension, fasting glucose, homeostatic model assessment for insulin resistance, metabolic syndrome or T2D. Sensitivity analyses did not reduce heterogeneity. Despite substantial heterogeneity, social jetlag is associated with certain parameters of the metabolic syndrome and T2D, but not with prevalent metabolic syndrome or T2D. These findings should be interpreted with caution as the level of evidence is low and mostly based on cross‐sectional data. Longitudinal studies are needed to further assess the direction of causality.
Single‐dose pharmacokinetics of telmisartan oral solution and effect of feeding in dogs
Authors: Bechtel Allison G. , Reinhart Jennifer M. , Li Zhong 
Published: November 2022

AbstractTelmisartan is an angiotensin II receptor blocker that has great potential to improve the treatment of hypertension, proteinuria, and cardiovascular disease in dogs. A feline‐approved telmisartan oral solution (TOS) is available, but this formulation has not been evaluated in dogs. The aims of this study were to establish the pharmacokinetics of telmisartan administered as TOS and determine the effect of feeding on drug absorption in dogs. In a cross‐over design, seven healthy dogs received 1 mg/kg telmisartan orally as TOS with or without food and underwent serial measurement of plasma telmisartan concentrations over 24 h. Bioequivalence of TOS administered with vs. without food was assessed by the 90% confidence interval method for maximum concentration (Cmax), and the observed and extrapolated areas under the curve (AUC0–t and AUC0–∞). The mean ratios of these parameters were 0.97 (CI 0.74–1.27), 0.92 (0.81–1.03), and 0.90 (0.82–1.00), respectively. Feeding methods were not bioequivalent based on Cmax due to interindividual variation. These results suggest that TOS can be given to dogs with or without food but should be administered in the same way consistently. Additional pharmacokinetic and pharmacodynamic studies are warranted to confirm this recommendation and establish the therapeutic targets for telmisartan in dogs.
Unravelling the historical biogeography of the European rabbit subspecies in the Iberian Peninsula
Authors: Díaz‐Ruiz Francisco , Vaquerizas Patricia H. , Márquez Ana Luz , Delibes‐Mateos Miguel , Piorno Vicente , Castro Francisca , Ramírez Esther , Farfán Miguel Ángel , Olivero Jesús , Real Raimundo , Villafuerte Rafael 
Published: November 2022

Abstract

Understanding the biogeography of species in space and time is essential for the development of evidence‐based conservation and management plans. In this paper we propose a biogeographical spatial modelling approach based on the favourability function, and developed under a fuzzy logic framework, to unravel the historical biogeography of the two European wild rabbit subspecies, Oryctolagus cuniculus algirus (Oca) and Oryctolagus cuniculus cuniculus (Occ), in the Iberian Peninsula (IP).

We first reviewed published and unpublished information (PhD theses, scientific papers, technical reports, etc.) on the occurrence of each rabbit subspecies throughout the IP. We compiled data from 201 Iberian rabbit populations and from genetic information of 4348 rabbits that was used to identify subspecies. Only populations in which all rabbits surveyed belonged to one subspecies were considered in the modelling procedure.

We modelled rabbit subspecies' distribution separately for populations in which nuclear and mitochondrial DNA sequences were available. We employed a trend surface analysis developed by logistic regressions, which applied the favourability function and fuzzy logic operations.

Using our approach we indentify the expansion cores from which both rabbit subspecies would have expanded after isolation during the last glaciations. Furthermore, we reveal the possible existence of a competitive exclusion zone between both rabbit subspecies that may have prevented their further expansion. Finally, our study shows that the Oca subspecies is distributed in north‐western areas previously attributed to Occ.

This assessment of the actual and historical distribution of each rabbit subspecies may allow more specific conservation interventions, as the two subspecies are not just genetically distinct but also ecologically and behaviourally different. Our methodological approach could be useful in unravelling the historical biogeography of other lesser‐known species.
Disk transport rates from Ti isotopic signatures of refractory inclusions
Authors: Render Jan , Bryson James F. J. , Ebert Samuel , Brennecka Gregory A. 
Published: November 2022

AbstractThe early solar system was a dynamic period during which the formation of early solids set into motion the process of planet building. Although both astrophysical observations and theoretical modeling demonstrate the presence of widespread transport of material, we lack concrete quantitative constraints on timings, distances, and mechanisms thereof. To trace these transport processes, one needs objects of known early formation times and these objects would need to be distributed throughout parent bodies with known accretion times and distances. Generally, these criteria are met by “regular” (i.e., non–fractionated and unidentified nuclear and excluding hibonite‐rich) Ca‐Al‐rich inclusions (CAIs) as these objects formed very early and close to the young Sun and contain distinctive nucleosynthetic isotope anomalies that permit provenance tracing. However, nucleosynthetic isotopic signatures of such refractory inclusions have so far primarily been analyzed in chondritic meteorites that formed within ~4 AU from the Sun. Here, we investigate Ti isotopic signatures of four refractory inclusions from the ungrouped carbonaceous chondrite WIS 91600 that was previously suggested to have formed beyond ~10 AU from the Sun. We show that these inclusions exhibit correlated excesses in 50Ti and 46Ti and lack large Ti isotopic anomalies that would otherwise be indicative of more enigmatic refractory materials with unknown formation ages. Instead, these isotope systematics suggest the inclusions to be genetically related to regular CAIs commonly found in other chondrites that have a broadly known formation region and age. Collectively, this implies that a common population of CAIs was distributed over the inner ~10 AU within ~3.5 Myr, yielding an average (minimum) speed for the transport of millimeter‐scale material in the early solar system of ~1 cm s−1.
Dysregulation of miR‐543 in Parkinson's disease: Impact on the neuroprotective gene SIRT1
Authors: Scheper Mirte , Iyer Anand , Anink Jasper J. , Mesarosova Lucia , Mills James D. , Aronica Eleonora 
Published: November 2022

AbstractAimsParkinson's disease (PD) is a progressive and age‐dependent neurodegenerative disease characterised clinically by a variety of motor symptoms and cognitive impairment. PD was initially considered to be a grey matter disease; however, recently, evidence has emerged that white matter changes in PD precede the neuronal loss seen in the grey matter. The cause of these initial white matter changes is yet to be elucidated. Here, we explored whether dysregulated miRNAs and their target mRNA could provide insight into the underlying mechanisms of early white matter changes in PD.MethodsWe analysed the expression of miRNAs in three different stages of PD through RNA‐sequencing and validated the differential expression of miRNAs through quantitative reverse transcription polymerase chain reaction. With bioinformatic analyses, we predicted target genes of dysregulated miRNAs and investigated their biomarker potential. Finally, in vitro, we confirmed the targetting of the gene SIRT1 by miR‐543.ResultsWe identified 12 dysregulated miRNAs in PD and found that miR‐543 holds potential as a biomarker for late‐stage PD with dementia. We report upregulation of miR‐543 in early PD white matter tissue and downregulation of SIRT1. In vitro experiments showed that the upregulation of miR‐543 results in the downregulation of SIRT1 in the white matter, but not in the grey matter.ConclusionsWe validated SIRT1 as a target of miR‐543 in the brain and showed its function as a potential biomarker. Our results highlight the idea that dysregulation of miR‐543 in early PD white matter, resulting in the dysregulation of SIRT1, potentially influencing the early white matter changes observed in PD.
Examining dietary behaviours, diet quality, motives and supplementation use in physically active individuals following vegetarian‐based eating patterns
Authors: Craddock Joel C. , Neale Elizabeth P. , Peoples Gregory E. , Probst Yasmine C. 
Published: November 2022

AbstractThe adoption of vegetarian‐based dietary patterns among athletes has been gaining popularity. However, limited research examines the dietary behaviours within this group. Therefore, the aim of this study was to examine self‐reported dietary behaviours in a cohort of physically active individuals following vegetarian‐based dietary patterns, recruited via social media. A 52‐item online survey was created with questions related to demographics, physical activity, eating patterns and supplementation use. An external link to the Australian Automated Self‐Administered 24‐h (ASA24‐AU) recall was included to examine nutrient intakes. Dietary quality was assessed using the Alternate Healthy Eating Index‐2010 (AHEI‐2010) and the Dietary Phytochemical Index (DPI) tools. A total of 781 (84.8%) respondents completed the survey in 2018. Principal motives for adhering to a vegetarian‐based dietary pattern included animal rights (86.5%), environmental concerns (75.4%), health reasons (69.6%) and improving physical performance (24.1%). Vitamin B12 was the most commonly reported supplement (58.1%) followed by protein powder (36.3%) and vitamin D (35.9%). A total of 133 respondents completed the ASA24‐AU dietary recall with generally adequate nutrient intakes and a high‐quality diet as assessed by the AHEI‐2010 and DPI. A significant minority of physically active individuals following vegetarian‐based diets do so with the aspiration of improving their exercise performance. Dietary quality was considered high in this group for recreational physical activity, although intakes of vitamin B12 and LC n‐3 PUFA were low.
Dual‐function C2H2‐type zinc‐finger transcription factor GmZFP7 contributes to isoflavone accumulation in soybean
Authors: Feng Yue , Zhang Shengrui , Li Jing , Pei Ruili , Tian Ling , Qi Jie , Azam Muhammad , Agyenim‐Boateng Kwadwo Gyapong , Shaibu Abdulwahab S. , Liu Yitian , Zhu Zuofeng , Li Bin , Sun Junming 
Published: November 2022

Summary
Isoflavones are a class of secondary metabolites produced by legumes and play important roles in human health and plant stress tolerance. The C2H2 zinc‐finger transcription factor (TF) functions in plant stress tolerance, but little is known about its function in isoflavone regulation in soybean (Glycine max).
Here, we report a C2H2 zinc‐finger TF gene, GmZFP7, which regulates isoflavone accumulation in soybean. Overexpressing GmZFP7 increased the isoflavone concentration in both transgenic hairy roots and plants. By contrast, silencing GmZFP7 expression significantly reduced isoflavone levels. Metabolomic and qRT‐PCR analysis revealed that GmZFP7 can increase the flux of the phenylpropanoid pathway. Furthermore, dual‐luciferase and electrophoretic mobility shift assays showed that GmZFP7 regulates isoflavone accumulation by influencing the expression of Isoflavone synthase 2 (GmIFS2) and Flavanone 3 β‐hydroxylase 1 (GmF3H1).
In this study, we demonstrate that GmZFP7 contributes to isoflavone accumulation by regulating the expression of the gateway enzymes (GmIFS2 and GmF3H1) of competing phenylpropanoid pathway branches to direct the metabolic flux into isoflavone. A haplotype analysis indicated that important natural variations were present in GmZFP7 promoters, with P‐Hap1 and P‐Hap3 being the elite haplotypes.
Our findings provide insight into how GmZFP7 regulates the phenylpropanoid pathway and enhances soybean isoflavone content.
Reverse structural left atrial remodeling and atrial tachycardia in patients with repeat ablation for atrial fibrillation
Authors: Hashiguchi Naotaka , Chiang Cheng‐Hung , Rottner Laura , Reißmann Bruno , Rillig Andreas , Maurer Tilman , Lemes Christine , Kuck Karl‐Heinz , Ouyang Feifan , Mathew Shibu 
Published: November 2022

AbstractBackgroundCatheter ablation has been evolved to a cornerstone in the therapy of atrial fibrillation (AF); however, atrial tachycardias (AT) after AF ablation are still an important issue. Besides the electrical recurrence of atrial tachyarrhythmia after ablation, left atrial (LA) remodeling has received attention as a consequence of AF.ObjectiveThe aim of this study is to evaluate predictors for AT recurrence and LA remodeling in patients with repeat AF ablation procedures.Methods and ResultsOne hundred thirteen patients who underwent repeat AF ablation with 3D electro‐anatomical mapping system were evaluated. Mean age was 63.1 ± 9.3 years, and 2.3 ± 0.5 ablation procedures were performed during a time period of 22 [IQR 7;48] months. Reverse structural LA remodeling (LA volume decreased more than 15%) was observed in 25 (22.1%) patients. LA volume index (LAVI) during first procedure was the only predictor for positive reverse structural LA remodeling (hazard ratio (HR): 1.03, 95% CI: 1.00–1.07, p = .036) in multivariate analysis. Fifty‐nine (52.2%) patients experienced only AF and 54 (47.8%) patients AT after first procedure. Female gender (HR: 5.21, 95% CI: 1.66–18.08, p = .006), LAVI (HR: 1.06, 95% CI: 1.02–1.11, p = .008) and LA scar percentage (HR: 1.08, 95% CI: 1.02–1.17, p = .019) were independent significant predictors for AT recurrence in multivariate analysis.ConclusionsReverse structural LA remodeling occurred in a quarter of patients with repeat ablation procedures for AF. Only larger LAVI during first procedure predicted reverse structural LA remodeling. Half of the patients experienced AT between first and last ablation procedure. Female gender, larger LAVI and larger scar area were significant predictors for AT after catheter ablation for AF.
Obsessional intrusive thoughts in children: An interview based study
Authors: García‐Soriano Gemma , Carrasco Ángel , Emerson Lisa Marie 
Published: November 2022

AbstractObjectivesWe aimed to investigate the experience of obsessional intrusive thoughts (OITs) in a sample of children aged 8 to 10 years old and to test the main tenets of the cognitive model of OCD. Specifically, we assessed: (1) the prevalence of OITs experienced by young children; (2) their frequency and content; (3) the emotions they evoke; (4) the reasons why they are upsetting; (5) how they are appraised (6) and what control strategies they use.MethodsForty‐nine children (28 girls, 21 boys; mean age 9.1 years) from the community completed two self‐report questionnaires assessing anxiety and obsessive–compulsive symptoms. Children were interviewed using the Children's Anxious Thoughts Interview, which assessed their experiences of OITs.ResultsFrom the 49 participants, 71.43% reported having experienced at least one OIT. The most frequent contents related to harm and doubt. Of the total sample, 28.6% reported having experienced one OIT recently with at least moderate frequency; these participants reported higher anxiety and obsessive–compulsive interference, described feeling nervous and anxious when experiencing their OIT, and rated their OIT as highly important and distracting. The most frequently reported control strategies were cognitive – suppression, distraction and thought replacement.ConclusionsAlmost two thirds of community children reported experiencing OITs. The findings from this study provide preliminary support for the application of the cognitive model of OCD in children. Subtle differences from previous research with adults are discussed.
Hepatitis B immunity among undergraduate nursing students: A brief report
Authors: Dawson Robin M. , Catledge Courtney , Scott Ann , Pate Leigh Blackmon , Vereen Gail 
Published: November 2022

AbstractBackgroundHealth sciences students who report low/equivocal hepatitis B titers may be required to repeat the immunization series, even though the result may not indicate non‐immunity.MethodTo describe hepatitis B immunity patterns, this retrospective, descriptive study utilized de‐identified vaccination records and anti‐HBs titers of three cohorts of sophomore nursing students entering clinical rotations in 2018–2019.ResultsOnly 33% of students had initial anti‐HBs quantitative serum titer ≥10 mIU/ml, demonstrating immunity. After students with low/equivocal titers (n = 191, 64%) were re‐immunized per institution protocol, only 2% (n = 7) were identified as non‐responders. Cumulative costs incurred by students for revaccination and repeat titer exceeded $20,000, with a process time of up to 8 months.ConclusionWhile rates of exposure to hepatitis B in acute care settings have steadily declined in the United States, students who go on to practice in community and public health settings have increased risk of exposure. Following best practices in demonstrating hepatitis B immunity, which include a single challenge dose followed by titer 4 weeks later, would decrease per student costs, wait time, and administrative burden associated with documentation and student counseling.
Virtual bronchoscopic navigation and endobronchial ultrasound with a guide sheath without fluoroscopy for diagnosing peripheral pulmonary lesions with a bronchus leading to or adjacent to the lesion: A randomized non‐inferiority trial
Authors: Zheng Xiaoxuan , Zhong Changhao , Xie Fangfang , Li Shiyue , Wang Guiqi , Zhang Lei , Sun Jiayuan 
Published: November 2022

AbstractBackground and ObjectiveTransbronchial sampling of peripheral pulmonary lesions (PPLs) is routinely performed under fluoroscopy. However, advanced ancillary techniques have become available, such as virtual bronchoscopic navigation (VBN) and radial endobronchial ultrasound with a guide sheath (rEBUS‐GS). This study was performed to determine whether the diagnostic utility of VBN and rEBUS with a GS is similar with or without fluoroscopy.MethodsThis multicenter non‐inferiority trial randomized patients to a VBN‐rEBUS‐GS with or without fluoroscopy group at three centres. The primary endpoint was the diagnostic yield. The secondary endpoints were the time for rEBUS, GS, and the total operation. Complications were also recorded.ResultsFour hundred and ninety‐six subjects were assessed and 426 subjects were included in the analysis (212 in non‐fluoroscopy‐guided‐group and 214 in fluoroscopy‐guided‐group). The diagnostic yield in the non‐fluoroscopy‐guided‐group (84.0%) was not inferior to that in the fluoroscopy‐guided‐group (84.6%), with a diagnostic difference of −0.6% (95% CI: −6.4%, 5.2%). Multivariable analysis confirmed that bronchus sign and lesion nature were valuable diagnostic predictors in non‐fluoroscopy‐guided‐group. The non‐fluoroscopy‐guided‐group had shorter rEBUS, GS, and total operation time. No severe complications occurred in either group.ConclusionTransbronchial diagnosis of PPLs suspicious of malignancy and presence of a bronchus leading to or adjacent to lesions using VBN‐rEBUS‐GS without fluoroscopy is a safe and effective method that is non‐inferior to VBN‐rEBUS‐GS with fluoroscopy. Bronchus leading to lesions and malignant nature are associated with high diagnostic yield in VBN‐rEBUS‐GS without fluoroscopy for the diagnosis of PPLs.
Financial globalization and monetary transmission
Authors: Auer Simone 
Published: November 2022

AbstractThis article studies the way in which international financial integration affects the domestic transmission of monetary policy in a standard New Keynesian open economy model. It extends Woodford's (2010) model to a framework, in which not only a global integration of goods and factor markets, but also financial markets might matter for the monetary transmission mechanism. The article considers two broad types of experiments meant to capture financial integration, a decrease in the costs of international asset trading and an increase in the level of gross foreign asset holdings. The main finding is that none of the analyzed forms of financial integration undermine the effectiveness of monetary policy in influencing domestic output and inflation. On the contrary, under a wide array of parameterizations, and even in an environment where the exchange rate pass‐through elasticity is very low and the Home country's traded goods sector is very small compared to world markets, monetary policy is more, rather than less, effective as the positive impact of strengthened exchange rate and wealth channels more than offsets the negative impact of weakened interest rate channels. Monetary policy is most effective in simulations interacting the highest degrees of the two forms of financial integration.