bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tools for Identifying Potentially Inappropriate Prescriptions for Children and Their Applicability in Clinical Practices: A Systematic Review
Authors: Li Siyu , Huang Liang , Chen Zhe , Zeng Linan , Li Hailong , Diao Sha , Jia Zhi-Jun , Cheng Guo , Yu Qin , Zhang Lingli 
Published: May 2022

Background: Drug use safety in children is a global public health problem. The potentially inappropriate prescription screening tools are expected to reduce adverse drug reactions and promote rational drug use.Objectives: To systematically evaluate children’s potentially inappropriate prescription screening tools and validation studies on these tools.Methods: We systematically searched six databases PubMed, Embase, Cochrane Library, CNKI, VIP and Wanfang Data. Two reviewers independently selected articles by the eligible criteria and extracted data. Then we evaluated the coverage of diseases or drugs in these tools and the consistency of items between tools.Results: Five children’s potentially inappropriate prescription screening tools were identified, most tools were formed by Delphi expert consensus and focused on respiratory system drugs, anti-infective drugs, and gastrointestinal drugs. The coincidence rates of items between the POPI and the POPI Int, the POPI and the POPI United Kingdom, the POPI United Kingdom and the POPI int, and the POPI United Kingdom and the PIPc were 82.0, 55.1, 51.0 and 2.2% respectively, and the KIDs List did not overlap other four tools. Only the POPI tool developed by French experts was comprehensively validated by studies and most tools have not been validated.Conclusion: The development of screening tools for potentially inappropriate prescribing in children is a neglected field and most tools lack studies to validate clinical applicability. More researchers need to form their national potentially inappropriate prescription screening tools for children based on the best available clinical evidence and the actual clinical situation in their countries.
Yokukansan Inhibits the Development of Morphine Tolerance by Regulating Presynaptic Proteins in DRG Neurons
Authors: Ohashi Yusuke , Sakhri Fatma Zahra , Ikemoto Hideshi , Okumo Takayuki , Adachi Naoki , Sunagawa Masataka 
Published: May 2022

Opioids, such as morphine, are used in clinical settings for the management of acute and chronic pain. However, long-term use of morphine leads to antinociceptive tolerance and hypersensitivity. The cellular and molecular mechanisms of morphine tolerance seem to be quite complex, with suggestions including internalization of the μ-opioid receptor (MOR), neuroinflammation with activation of microglia and astrocytes, and changes in synaptic function in the central nervous system. Yokukansan (YKS), a traditional Kampo medicine consisting of seven herbs, has been used to treat emotional instability, neurosis, and insomnia. Interestingly, recent studies have begun to reveal the inhibitory effect of YKS on the development of morphine tolerance. In the present study, we determined the effect of YKS on morphine tolerance formation and its mechanisms in a rat model, focusing on the synapses between primary sensory neurons and spinal dorsal horn secondary neurons. We found that morphine tolerance formation was significantly inhibited by YKS (0.3 or 1.0 g/kg/day) preadministration for 7 days. Repeated administration of morphine (10 mg/kg/day) increased the expression of presynaptic proteins, including synaptotagmin I, in the spinal cord, which was suppressed by YKS. Furthermore, these changes in presynaptic protein expression were more pronounced at isolectin B4 (IB4)-positive excitatory synapses around the lamina II of the dorsal horn. These results suggest that YKS suppresses the development of morphine tolerance by inhibiting the enhancement of presynaptic function of dorsal root ganglia neurons projecting to spinal dorsal horn neurons caused by continuous morphine administration.
An Agile Systems Modeling Framework for Bed Resource Planning During COVID-19 Pandemic in Singapore
Authors: Lam Sean Shao Wei , Pourghaderi Ahmad Reza , Abdullah Hairil Rizal , Nguyen Francis Ngoc Hoang Long , Siddiqui Fahad Javaid , Ansah John Pastor , Low Jenny G. , Matchar David Bruce , Ong Marcus Eng Hock 
Published: May 2022

BackgroundThe COVID-19 pandemic has had a major impact on health systems globally. The sufficiency of hospitals' bed resource is a cornerstone for access to care which can significantly impact the public health outcomes.ObjectiveWe describe the development of a dynamic simulation framework to support agile resource planning during the COVID-19 pandemic in Singapore.Materials and MethodsThe study data were derived from the Singapore General Hospital and public domain sources over the period from 1 January 2020 till 31 May 2020 covering the period when the initial outbreak and surge of COVID-19 cases in Singapore happened. The simulation models and its variants take into consideration the dynamic evolution of the pandemic and the rapidly evolving policies and processes in Singapore.ResultsThe models were calibrated against historical data for the Singapore COVID-19 situation. Several variants of the resource planning model were rapidly developed to adapt to the fast-changing COVID-19 situation in Singapore.ConclusionThe agility in adaptable models and robust collaborative management structure enabled the quick deployment of human and capital resources to sustain the high level of health services delivery during the COVID-19 surge.
Relationship Between Lipid Profiles and Hypertension: A Cross-Sectional Study of 62,957 Chinese Adult Males
Authors: Chen Siwei , Cheng Wenke 
Published: May 2022

BackgroundPatterns of dyslipidemia and incidence of hypertension have been rarely reported in Asian populations with inconsistent findings. To accumulate further evidence in Asian populations, the study aimed to investigate the relationship between lipid profiles and hypertension in Chinese adult males.MethodsWe conducted a cross-sectional study based on the data from the DATADRYAD database. The overall population was divided into hypertensive and non-hypertensive groups based on baseline blood pressure levels. For continuous variables, Mann-Whitney test was performed between two groups, while Kruskal-Wallis and Dunn tests were used among multiple groups. The chi-square test was carried out for dichotomous variables. Spearman's correlation coefficient was employed to assess the association between systolic blood pressure (SBP), diastolic blood pressure (DBP) and lipid profiles, whereas the relationship between lipid profiles and the incidence of hypertension was evaluated using multivariate logistic regression. The Bayesian network (BN) model was adopted to investigate the relationship between clinical characteristics and hypertension, and the importance of related predictor to the incidence of hypertension was obtained to make conditional probability analysis.ResultsFinally, totally 62,957 participants were included in this study. In the lipid profiles, total cholesterol (TC), low-density cholesterol (LDL-c), and non- high-density lipoprotein cholesterol (non-HDL-c) were higher in the hypertensive population (p &lt;0.001). In the fully multivariate model, for every 1 mg/dl increase in TC, LDL-c and non-HDL, the risk of hypertension increased by 0.2% [1.002 (1.001–1.003)], 0.1% [1.001 (1.000–1.002)], and 0.1% [1.001 (1.000–1.002)]. Meanwhile, HDL-c became positively associated with the incidence of hypertension (p for trend &lt; 0.001) after adjusting for the body mass index (BMI), and 1 mg/dl increment in HDL-c increased the risk of hypertension by 0.2% [1.002 (1.000–1.002)] after fully adjusting for multiple variables. Furthermore, the BN showed that the importance of age, BMI, fasting plasma glucose (FPG), and TC to the effect of hypertension is 43.3, 27.2, 11.8, and 5.1%, respectively.ConclusionElevated TC, LDL-c, and non-HDL-c were related to incidence of hypertension in Chinese adult males, whereas triglycerides (TG) was not significantly associated. The relationship between HDL-c and hypertension incidence shifted from no association to a positive correlation after adjusting for the BMI. Moreover, the BN model displayed that age, the BMI, FPG, and TC were strongly associated with hypertension incidence.
Estimating Inner Magnetospheric Radial Diffusion Using a Hybrid-Vlasov Simulation
Authors: George H. , Osmane A. , Kilpua E. K. J. , Lejosne S. , Turc L. , Grandin M. , Kalliokoski M. M. H. , Hoilijoki S. , Ganse U. , Alho M. , Battarbee M. , Bussov M. , Dubart M. , Johlander A. , Manglayev T. , Papadakis K. , Pfau-Kempf Y. , Suni J. , Tarvus V. , Zhou H. , Palmroth M. 
Published: May 2022

Radial diffusion coefficients quantify non-adiabatic transport of energetic particles by electromagnetic field fluctuations in planetary radiation belts. Theoretically, radial diffusion occurs for an ensemble of particles that experience irreversible violation of their third adiabatic invariant, which is equivalent to a change in their Roederer L* parameter. Thus, the Roederer L* coordinate is the fundamental quantity from which radial diffusion coefficients can be computed. In this study, we present a methodology to calculate the Lagrangian derivative of L* from global magnetospheric simulations, and test it with an application to Vlasiator, a hybrid-Vlasov model of near-Earth space. We use a Hamiltonian formalism for particles confined to closed drift shells with conserved first and second adiabatic invariants to compute changes in the guiding center drift paths due to electric and magnetic field fluctuations. We investigate the feasibility of this methodology by computing the time derivative of L* for an equatorial ultrarelativistic electron population travelling along four guiding center drift paths in the outer radiation belt during a 5 minute portion of a Vlasiator simulation. Radial diffusion in this simulation is primarily driven by ultralow frequency waves in the Pc3 range (10–45 s period range) that are generated in the foreshock and transmitted through the magnetopause to the outer radiation belt environment. Our results show that an alternative methodology to compute detailed radial diffusion transport is now available and could form the basis for comparison studies between numerical and observational measurements of radial transport in the Earth’s radiation belts.
The Road to Technical Proficiency in Cytoreductive Surgery for Peritoneal Carcinomatosis: Risk-Adjusted Cumulative Summation Analysis
Authors: Santullo Francesco , Abatini Carlo , Attalla El Halabieh Miriam , Ferracci Federica , Lodoli Claudio , Barberis Lorenzo , Giovinazzo Francesco , Di Giorgio Andrea , Pacelli Fabio 
Published: May 2022

BackgroundCytoreductive surgery (CRS) is a technically demanding procedure, and there is considerable debate about its safe application. This study investigated the learning curve for CRS and the clinical outcomes of consecutive patients treated by a single surgeon at a single institution.MethodsWe collected 251 consecutive patients who underwent CRS for peritoneal metastases by a single surgeon at Fondazione Policlinico Universitario A. Gemelli IRCCS, between January 2016 and December 2020. The learning curve was estimated using the cumulative summation analysis (CUSUM) for operative time (OT). Risk-adjusted CUSUM (RA-CUSUM) charts were developed using a composite variable (surgical failure), defined as the occurrence of at least one of the following events: major postoperative complications (Clavien–Dindo grade ≥3), blood loss ≥500 mL, incomplete cytoreduction. Three learning phases were thus derived from the RA-CUSUM analysis, and were compared in terms of perioperative outcomes.ResultsCUSUM-OT showed that the operation time improved significantly after the 161th case. RA-CUSUM analysis allowed to break the CRS learning curve into three different phases: phase 1, “the learning phase” (cases 1–99), phase 2 “the experienced phase” (cases 100–188), and phase 3, “the mastership phase” (cases 189–251). The rate of major postoperative complications decreased significantly over the three phases (p = 0.019). Operative time decreased significantly as well (p = 0.031) and was significantly shorter in phase 3 with respect to the other two phases (phase 3 vs phase 2: 420 min vs 500 min, p = 0.017; phase 3 vs phase 1: 420 min vs 503 min, p = 0.021). Blood loss consistently decreased throughout the three phases (p = 0.001). The rate of incomplete cytoreduction was significantly lower in phase 3 than in phase 2 (4.8% vs 14.6%, p = 0.043).ConclusionThe CRS failure rate stabilized after the first 99 cases, and the complete surgical proficiency was achieved after 189 cases. A standardised and mentored learning model is a safer strategy to shorten the learning process, to reduce morbidity and mortality, to improve oncologic outcomes.
The Association Between Dietary Intake and Improvement of LARS Among Rectal Cancer Patients After Sphincter-Saving Surgery-A Descriptive Cohort Study
Authors: Liu Wen , Xia Hai Ou 
Published: May 2022

BackgroundDietary management was an important strategy for controlling low anterior resection syndrome (LARS) after sphincter-saving surgery, however, the influencing dietary factors of LARS are not completely clear. This study aims at exploring the specific association between perioperative intake of foods and nutrients and the improvement of LARS within the first 6 months after surgery.MethodsThis study applied a prospective cohort design. 210 consecutive patients were admitted in the colorectal surgical ward after the sphincter-saving surgery in a tertiary hospital in China from May to November in 2020. The perioperative food intake was assessed by the food frequency questionnaire, and the bowel symptoms were assessed by the Low Anterior Resection Syndrome Score Scale. The binary logistic regression was used to analyze the collected data.ResultsIt was found out that both the intake of oil before surgery and at 6 months after surgery were significantly associated with the improvement of LARS. The average daily intake of livestock and poultry meats and oil during the first 6 months after sphincter-saving surgery were also associated with the improvement of LARS.ConclusionsThe relationship between the intake of Livestock and poultry meats and oil and the improvement of LARS was significant in this study. It provides evidence for medical staff to make up effective interventions of moderating diet to promote the relief of LARS during the first 6 months after sphincter-saving surgery.
Evaluation of Serum AMH, INHB Combined with Basic FSH on Ovarian Reserve Function after Laparoscopic Ovarian Endometriosis Cystectomy
Authors: Tang Yan , Li Yanning 
Published: May 2022

ObjectiveThe value of serum AMH, INHB, and bFSH levels in assessing postoperative ovarian reserve function was analyzed by measuring serum anti-Mullerian hormone (AMH), inhibin B (INHB), and basal follicle-stimulating hormone (bFSH) levels in patients after laparoscopic cystectomy for endometrioma.MethodsFrom June 2019 to December 2021, 124 patients underwent laparoscopic cystectomy for endometrioma in our hospital were selected, and the serum AMH, INHB, bFSH level, antral follicle count (AFC) of all patients before and after operation were detected and compared. According to the results of postoperative testing, all the patients were divided into normal group (n = 86), diminished ovarian reserve (DOR) group (n = 27), and premature ovarian failure (POF) group (n = 11). Pearson correlation model and subject operating characteristic curve (ROC) were used to analyze the correlation and diagnostic value of serum AMH, INHB and bFSH levels with postoperative ovarian reserve function, respectively.ResultsAfter operation, the levels of serum AMH, INHB and AFC in the DOR group and POF group decreased compared with those before the operation, and the serum bFSH levels increased (p &lt; 0.05). After operation, the levels of serum AMH, INHB and AFC in DOR group and POF group were lower than those in normal group,and the serum bFSH levels were higher than the normal group; the levels of serum AMH, INHB and AFC in POF group were lower than those in DOR group, and the serum bFSH levels were higher than the DOR group (p &lt; 0.05). Pearson analysis showed that serum AMH and INHB levels were negatively correlated with bFSH, and positively correlated with the number of AFC, the serum bFSH level was negatively correlated with the number of AFC (p &lt; 0.05). The diagnostic values of serum AMH, bFSH, INHB and the combination of the three tests for postoperative abnormal ovarian reserve function were 0.866 (95% CI, 0.801–0.923), 0.810 (95% CI, 0.730–0.890), 0.774 (95% CI, 0.687–0.860) and 0.940 (95% CI, 0.900–0.981), respectively.ConclusionSerum AMH and INHB levels decreased and bFSH levels increased in patients after laparoscopic cystectomy for endometrioma, both of which were closely related to postoperative ovarian reserve function, and both could evaluate ovarian reserve function after ovarian cyst debulking, and the combined test could significantly improve the detection rate.
Prolonged-Release Once-Daily Formulation of Tacrolimus Versus Standard-of-Care Tacrolimus in de novo Kidney Transplant Patients Across Europe
Authors: Budde Klemens , Rostaing Lionel , Maggiore Umberto , Piotti Giovanni , Surace Daniela , Geraci Silvia , Procaccianti Claudio , Nicolini Gabriele , Witzke Oliver , Kamar Nassim , Albano Laetitia , Büchler Matthias , Pascual Julio , Gutiérrez-Dalmau Alex , Kuypers Dirk , Wekerle Thomas , Głyda Maciej , Carmellini Mario , Tisone Giuseppe , Midtvedt Karsten , Wennberg Lars , Grinyó Josep M. 
Published: May 2022

Background: Tacrolimus is the calcineurin inhibitor of choice for preventing acute rejection episodes in kidney transplant patients. However, tacrolimus has a narrow therapeutic range that requires regular monitoring of blood concentrations to minimize toxicity. A new once-daily tacrolimus formulation, LCP-tacrolimus (LCPT), has been developed, which uses MeltDose™ drug-delivery technology to control drug release and enhance overall bioavailability. Our study compared dosing of LCPT with current standard-of-care tacrolimus [immediate-release tacrolimus (IR-Tac) or prolonged-release tacrolimus (PR-Tac)] during the 6 months following de novo kidney transplantation. Comparisons of graft function, clinical outcomes, safety, and tolerability for LCPT versus IR-Tac/PR-Tac were also performed.Methods: Standard immunological risk patients with end-stage renal disease who had received a de novo kidney transplant were randomized (1:1) to LCPT (N = 200) or IR-Tac/PR-Tac (N = 201).Results: Least squares (LS) mean tacrolimus total daily dose from Week 3 to Month 6 was significantly lower for LCPT than for IR-Tac/PR-Tac. Although LS mean tacrolimus trough levels were significantly higher for LCPT than IR-Tac/PR-Tac, tacrolimus trough levels remained within the standard reference range for most patients. There were no differences between the groups in treatment failure measures or safety profile.Conclusion: LCPT can achieve similar clinical outcomes to other tacrolimus formulations, with a lower daily dose.Clinical Trial Registration:https://clinicaltrials.gov/, identifier NCT02432833.
A Correlational Predictive Study of Teacher Well-Being and Professional Success in Foreign Language Student Teachers
Authors: Cardoso-Pulido Manuel Jesús , Guijarro-Ojeda Juan Ramón , Pérez-Valverde Cristina 
Published: May 2022

The teaching profession has an important emotional burden that, together with the erosion of different elements that compose it from continuous educational reform to the bad behavior and demotivation of students has led to many teachers experiencing physical and psychological illness or leaving the profession. Nevertheless, studies and interventions in this regard are still insufficient in the Spanish context. This situation also exponentially affects pre-service teachers, which according to numerous studies is the stage during which the diminishing of teacher well-being begins and consolidates. Within this panorama, with this study the authors pursue to determine which dimensions of teacher well-being are capable of predicting the professional success of 88 pre-service primary education teachers who specialize in a foreign language so that they can be addressed in the training process. To this end, an ex post facto study was carried out correlating the following instruments: the Teacher Distress Questionnaire, the Trait Emotional Intelligence Questionnaire and the Maslach Burnout Inventory-Educators Survey with an adaptation of the Rueda de la vida escolar sobre el éxito y la satisfacción laboral del docente (Wheel of school life on teacher success and job satisfaction). Multiple linear regression revealed that of all the variables studied for teacher well-being (intrinsic motivation, expectations about good professional performance, professional distress, professional exhaustion, irrational beliefs, emotional intelligence and burnout) only emotional intelligence and intrinsic motivation have the ability to predict the success of teachers in training in their future professional performance. This result is of paramount importance for reconsidering the training that teachers receive during their university stage, which currently and substantially prioritizes the cognitive component over psychosocial and emotional components.
ANALYSIS OF THE DEVELOPMENT OF THE INDUSTRIAL COMPLEX OF THE CHECHEN REPUBLIC: SEARCH FOR POSSIBLE “POINTS OF GROWTH”
Authors: Ахмадов М-Э. И. , Хлебников К. В. , Якубов Т. В. 
Published: May 2022

В большинстве случаев промышленный комплекс является основой экономики регионов, поскольку обеспечивает основной вклад в формирование ВРП. На сегодняшний день доля промышленного комплекса региона в ВРП составляет не более 6%. В Чеченской Республике 2022 год объявлен годом промышленности, что подчеркивает масштаб усилий региональных органов власти, направленных на качественный рост данного сектора экономики. В статье анализируются динамика основных показателей промышленного комплекса республики, а также рассматривается деятельность основных составляющих элементов: добывающего сектора и обрабатывающих производств. Что, в свою очередь, позволило выделить те специализированные производства, которые могли бы стать «точками роста» экономики региона.
In most cases, the industrial complex is the basis of the regional economy, since it provides the main contribution to the formation of GRP. Unfortunately, this cannot be said about the industrial complex of the Chechen Republic, whose contribution to the GRP is no more than 6%. In the Czech Republic, 2022 has been declared the year of industry, which underlines the scale of the efforts of regional authorities aimed at the qualitative growth of this sector of the economy.The article analyzes the dynamics of the main indicators of the industrial complex of the Czech Republic, and also examines the activities of the main constituent elements: the extractive sector and manufacturing industries. Which, in turn, made it possible to single out those specialized industries that could become “growth points” for the region’s economy.