bluuebunny/crossref_metadata_2025_split huggingface dataset:
Approximately Three Years of Prolotherapy Experience of a Traditional and Complementary Medicine Center: An Epidemiologic Study
Authors: SOLMAZ İlker , ÖRSÇELİK Aydan 
Published: February 2022

Objective: Prolotherapy is a regenerative injection-based treatment which is increasingly using in musculoskeletal disorders. There are studies about the usage of prolotherapy in diseases but there is not an epidemiological study in the literature. The aim of this study is to resolve the lack of epidemiological studies about prolotherapy.
Materials-Methods: Ten-thousand-three-hundred-nineteen patients who were applied to our outpatient clinic between January 1, 2017 and 2021 were included in the study.
Results: The number of patients’ injured area was 10319 with the mean age of 54.2±13.8. 2886 male (28.0%) and 7433 females (72.0%) were evaluated, and 844 of these patients (8.2%) did not receive the treatment. The reasons for admission / treatment of the patients were 35.3% (3647) low back and hip pain, 33.9% (3503) osteoarthritis of the knee, 13.3% (1369) neck pain. The number of sessions was 3.90±2.0 for completed treatments. Treatment results of the patients showed a significant difference according to gender (p
La performatività posthuman
Authors: Patti Federica 
Published: February 2022

L’accelerazione tecnologica continua a rivoluzionare la liveness lasciando emergere un alto gradiente di performatività anche nelle semplici abitudini multimediali quotidiane. L’ubiquità pervasiva dei media digitali influenza profondamente i modi e gli stili in cui la performance viene agita e fruita. Attivando efficaci dinamiche di connessione e coinvolgimento del pubblico, strumenti come lo streaming, la realtà virtuale e aumentata, l’intelligenza artificiale, il mapping, l’interaction design consentono oggi di allestire esperienze multimediali che offrono una dimensione sociale e comunicativa completamente diversa, all’insegna della transdisciplinarietà e dell’approccio post-antropocentrico. La live media performance è da considerarsi quindi come specifico settore di produzione artistica e di indagine, in cui è possibile far rientrare diverse tipologie di formati e pratiche. Gli agenti elettronici in scena vengono progettati per trasmettere un senso di interconnessione profonda tra i protagonisti, il pubblico e tutto ciò che li circonda. Il palcoscenico diventa così una dimensione sospesa, un “luogo della mente” sinestetico e immersivo, in cui viene ricostruita la realtà come risultato di un agire non soltanto umano. La tecnosfera diviene in questo senso un partner di lavoro. Attraverso l’analisi di ricerche e di linguaggi artistici multimediali performativi emblematici di questo settore disciplinare, si proporrà una suggestione interpretativa transdisciplinare post-antropocentrica e postumana, prestando attenzione alle forme sia umane sia non umane di azione e gesto espressivo.
KARAKTERISTIK PENGGUNA TUMBUHAN OBAT DI HUTAN LINDUNG JOMPI KABUPATEN MUNA SULAWESI TENGGARA
Authors: Ernikawati Ernikawati , Zuhud Ervizal AM , Santosa Yanto 
Published: February 2022

Karakteristik pengguna tumbuhan obat oleh masyarakat hutan lindung Jompi dikenal sebagai bahan obat-obatan tropis yang dapat menyembuhkan barbagai macam penyakit. Tujuan penelitian ini yaitu untuk mengkaji karakteristik pengguna tumbuhan obat berdasarkan tingkat umur, pendidikan, pendapatan, jumlah tanggungan keluarga, pengetahuan lokal dan mata pencaharian. Metode penelitian yang digunakan yaitu wawancara terhadap 30 responden. Hasil penelitian menunjukan bahwa karakteristik responden berdasarkan umur produktif dewasa madya berjumlah 14 orang atau 46.67%, pendidikan (tamat SD) berjumlah 17 orang atau 43.33%, pendapatan sebanyak 17 orang atau 56.67, jumlah tanggungan keluarga berjumlah 8 orang atau (26.67%), pengetahuan lokal yaitu masyarakat lokal berjumlah 20 orang atau (66.67%) serta berdasarkan mata pencaharian yaitu petani berjumlah 15 orang atau 50%. Simpulan utama dari penelitian ini bahwa karakteristik responden pengguna tumbuhan obat sangat berkaitan erat dengan memanfaatkan tumbuhan obat.
Aktivity podporující rozvoj nepřímých strategií učení v současných učebnicích francouzštiny pro dospělé studenty
Authors: Pecková Simona 
Published: February 2022

Cílem této práce je zjistit, zda a do jaké míry současné učebnice obecného francouzského jazyka pro dospělé podporují u studentů rozvoj nepřímých strategií učení. Metodou výzkumu byla obsahová analýza, při které jsme detailně prozkoumali 5 sérií současných učebnic francouzského jazyka. Bylo zjištěno, že většina z těchto sérií učebnic nepřímé strategie učení rozvíjí spíše v menší míře. Za nejzdařilejší v tomto ohledu považujeme sérii Nouveau Rond-Point. Autoři této řady učebnic věnují pozornost všem typům nepřímých strategií učení – tj. jak metakognitivní, tak afektivní i socializační.
An Audit on Pharmacists' Knowledge and Experience in Pediatric Care
Authors: Alqudah Mohammad A.Y. , Mukattash Tareq L. , Al-Shammari Esra'a , Jarab Anan S. , Al-Qerem Walid , Abu-Farha Rana K. 
Published: February 2022

OBJECTIVE
The aim of this study was to determine pharmacists' perceived knowledge and expertise required to deliver pharmaceutical care services to pediatric patients.

METHODS
Once ethical approval was obtained, a questionnaire was posted on local pharmacy groups. The questionnaire is composed of 4 domains: 1) Demographics, 2) Perceived knowledge of pediatric treatment and dosing, 3) Real-life pediatric cases, and 4) Future aspirations to enhance pediatric pharmacy.

RESULTS
A total of 200 questionnaires were completed and submitted online. Most participants (62.5%) practiced in a community setting. Most respondents (40%) reported that 41% to 60% of their patients were pediatrics. In general, respondents had a good perception of their knowledge and expertise to deliver pharmaceutical care services to pediatric patients. However, most respondents had a low knowledge score when faced with real-life pediatric cases. On a scale of 7 most respondents obtained the score of 2 (32%).

CONCLUSIONS
The present study sheds light on an alarming lack of knowledge in pediatric pharmaceutics among pharmacies in Jordan. Further training and educational programs should be put in place to address this gap in knowledge.
Robustness of autoencoders for establishing psychometric properties based on small sample sizes: results from a Monte Carlo simulation study and a sports fan curiosity study
Authors: Lin Yen-Kuang , Lee Chen-Yin , Chen Chen-Yueh 
Published: February 2022

Background
The principal component analysis (PCA) is known as a multivariate statistical model for reducing dimensions into a representation of principal components. Thus, the PCA is commonly adopted for establishing psychometric properties, i.e., the construct validity. Autoencoder is a neural network model, which has also been shown to perform well in dimensionality reduction. Although there are several ways the PCA and autoencoders could be compared for their differences, most of the recent literature focused on differences in image reconstruction, which are often sufficient for training data. In the current study, we looked at details of each autoencoder classifier and how they may provide neural network superiority that can better generalize non-normally distributed small datasets.

Methodology
A Monte Carlo simulation was conducted, varying the levels of non-normality, sample sizes, and levels of communality. The performances of autoencoders and a PCA were compared using the mean square error, mean absolute value, and Euclidian distance. The feasibility of autoencoders with small sample sizes was examined.

Conclusions
With extreme flexibility in decoding representation using linear and non-linear mapping, this study demonstrated that the autoencoder can robustly reduce dimensions, and hence was effective in building the construct validity with a sample size as small as 100. The autoencoders could obtain a smaller mean square error and small Euclidian distance between original dataset and predictions for a small non-normal dataset. Hence, when behavioral scientists attempt to explore the construct validity of a newly designed questionnaire, an autoencoder could also be considered an alternative to a PCA.
Autophagy-related prognostic signature for survival prediction of triple negative breast cancer
Authors: Yang Qiong , Sun Kewang , Xia Wenjie , Li Ying , Zhong Miaochun , Lei Kefeng 
Published: February 2022

Background
Triple-negative breast cancer (TNBC) is a highly aggressive type of cancer with few available treatment methods. The aim of the current study was to provide a prognostic autophagy-related gene (ARG) model to predict the outcomes for TNBC patients using bioinformatic analysis.

Methods
mRNA expression data and its clinical information for TNBC samples obtained from The Cancer Genome Atlas (TCGA) and Metabric databases were extracted for bioinformatic analysis. Differentially expressed autophagy genes were identified using the Wilcoxon rank sum test in R software. ARGs were downloaded from the Human Autophagy Database. The Kaplan–Meier plotter was employed to determine the prognostic significance of the ARGs. The sample splitting method and Cox regression analysis were employed to establish the risk model and to demonstrate the association between the ARGs and the survival duration. The corresponding ARG-transcription factor interaction network was visualized using the Cytoscape software.

Results
A signature-based risk score model was established for eight genes (ITGA3, HSPA8, CTSD, ATG12, CLN3, ATG7, MAP1LC3C, and WIPI1) using the TCGA data and the model was validated with the GSE38959 and Metabric datasets, respectively. Patients with high risk scores had worse survival outcomes than those with low risk scores. Of note, amplification of ATG12 and reduction of WIPI were confirmed to be significantly correlated with the clinical stage of TNBC.

Conclusion
An eight-gene autophagic signature model was developed in this study to predict the survival risk for TNBC. The genes identified in the study may favor the design of target agents for autophagy control in advanced TNBC.
Deviated Nasal Septum in Left Side Nose: A Case Report
Authors: Mandhare Sunny Rushidas , Meshram Priyanka S. , Bhagat Ashish , Damahe Lalit B. 
Published: February 2022

Introduction: When the thin wall that separates your right and left nasal passageways, your nasal septum, is moved to one side, you have a deviated septum. A disorder that is present at birth can create a deviated septum. A deviated septum can form during prenatal development and become visible at birth in some situations.
Main Symptoms and Important Clinical Findings: One or both nostrils are blocked. This obstruction (blockage) can make breathing via the nose or nostrils difficult. Nosebleeds. Pain in the face. During sleep, there is a lot of noise. The nasal cycle is something to be aware of. A preference for sleeping on one side over the other.
Patient Information: A patient is 45year old, having chief complete is shortness of breath, chest pain, fatigue, coughing, and weakness. Patient admitted to the hospital on date 12-7-21.
Clinical Findings: The Patient appeared to be awake and oriented with an individual on general inspection. Nasal bleeding, congestion, loss of smell, runny lose or post-nasal drip headache patients with clinical symptoms that are very similar to those of our case have lately been described.
Medical Management: Decongestants are drugs that assist keep the airways on both sides of your nose open by reducing nasal tissue swelling. Antihistamines are antihistamines, which assist to avoid allergy symptoms such as a stuffy or runny nose—steroid nasal spray.
Nursing Management: Administered fluid replacement (DNS and RL), maintained intake and output charts, and monitored hourly vital signs.
Conclusion: Nasal obstruction is a prevalent complaint among patients when the septum has deviated, stressing the need for more effective procedures to aid physicians in recommending surgical therapy when a patient has a nasal septum deviation.
Correlation of Long Bone Length and Number of Nutrient Foramina – Importance in Everyday Clinical Practice
Authors: Dervišević Lejla , Dervišević Amela , Ajanović Zurifa , Hasanbegović Ilvana , Hadžihalilović Aida Sarač , Kapur Eldan , Dervišević Emina 
Published: February 2022

Aims: Nutrient artery is the principal source of nutrition to the long bones. The topography of nutrient foramina on long bones is well known, but it has not yet been established whether the number of nutritive foramina (NF) is related to total bone length. The objective of the present study was to study the correlation of total number of nutrient foramina and long bone length of upper and lower limb to provide detailed data on such features.
Study Design: A cross-sectional, descriptive study
Place and Duration of Study: Department of anatomy, Medical Faculty University of Sarajevo. Study duration was 3 months.
Methodology: In the present study, 300 adult human long bones of the upper (50 humeri, 50 radii, 50 ulnae) and lower (50 femora, 50 tibiae, 50 fibulae) limbs were investigated to determine the number of their nutrient foramina. The nutrient foramina were identified analysed macroscopically and total number of nutrient foramina for each bone was recorded. Total length of each bone within a group was recorded. Statistical analysis was performed to determine correlation between total bone length and number of nutrient foramina, by using SPSS version 17.0 for Windows.
Results: A statistically significant negative correlations between the left humerus length and the number of NF was found. A positive correlations between the length of the right radius and the number of NF, the left ulna length and the number of NF, the right ulna length and the number of NF were found. A negative correlations between the length of the left radius and the number of NF and between right humerus length and number of NF were found. A positive correlation between the length of the right and left femur and the number of NF were found. A negative correlation between the length of left tibia and the number of NF was found, as well as negative correlation between the length of right and left fibula and number of NF.
Conclusion: Total bone length is not related to the number of nutrient foramina. The number of nutrient foramina does not depend on the total length of the bone, which is important when assessing the success of grafts for transplantation on long bones in taller people.
Establishment of Correlation of Ki-67 Proliferative Index Expression in the Peritumoral Tissue with Tumor Mass in ER (Estrogen Receptor) Positive Breast Carcinoma
Authors: Sukanya . , Dawande Pratibha , Bhake Arvind , Vagha Sunita 
Published: February 2022

Background: Breast carcinoma is the second most frequently occurring malignant tumor. It usually arises in a multistep fashion from intermediary lesions to invasive cancer. Identifying such predominantly occurring lesions adjacent to malignancy and studying of Proliferative Ki-67 index and (ER) status in such lesions and substantiate their possible identity as a premalignant lesion. The study tries to establish the lesions which have the potential for progression to overt malignancy, thereby indicating early identification and appropriate treatment.
Aim: To establish a correlation in the expression of Ki-67 proliferative index in the peritumoral tissue with tumor mass of ER-positive breast carcinomas.
Objectives: 1.To study the expression of ER in breast tumor mass. 2. To study expression of Ki-67 proliferative index in breast tumor mass and peritumoral tissue. 3. To assess the expression of Ki-67 proliferative index in breast tumor mass and peritumoral tissue. Study design: Observational prospective study.
Materials and Methods: 32 mastectomy specimens of diagnosed cases of breast carcinoma sent to the Histopathology Section are studied. Gross features are described and the histopathological section stained by (H & E) stain and immunohistochemistry using monoclonal antibody to (ER) and proliferation-associated antigen (Ki-67) are studied. Statistics: Chi-square test, Spearman’s rank-order correlation coefficient, and software used in the analysis were SPSS 22.0 version and Graph Pad Prism 6.0 version and p<0.05 is considered as the level of significance.
Results: In this study out of 32 ER-positive cases, 24 showed positivity for Ki-67 in tumor mass and 22 cases showed high Ki-67 in peritumoral tissue. Maximum lesions were proliferative lesions with atypia like ADH and DCIS.
Conclusion: Ki-67 is an accurate nuclear proliferative marker to assess cell proliferation status. In breast carcinoma adjacent peritumoral lesions show a high proliferative index which suggests a link and a trail of generation of premalignant lesions converting to invasive carcinoma. Proliferative lesions with and without atypia, moderate epithelioid, atypical ductal hyperplasia, and DCIS more or else equals IDC for Ki-67 proliferative index. Such cases should be regularly followed up for progression of these lesions to malignancy.
Comparative Evaluation of Efficacy of Modified Ashmaghnasveda (Stone Therapy) and Choornapindasveda in Management of Katigraha (Lumbar spondylosis)
Authors: Jain Anup , Sawarkar Punam 
Published: February 2022

Background: Katigraha is one of the most common illnesses affecting the Kati area, in which Vata gets are unbalanced in their own sthana (seat), resulting in Graha (stiffness) and Ruja (pain). Lumbar Spondylosis is a disease that causes back discomfort caused by spine movement and is accompanied by rigidity. Ashmaghnasveda is a key svedana treatment that helps with vataja, particularly Sama vataja and vatakaphaja illnesses. In this project, a structurally modified form of Ashmaghnasveda will be employed to produce ekangasveda. The goal of this study was to assess the efficacy of modified Ashmaghnasveda (stone therapy) and churnapindasveda in the treatment of Katigraha (lumbar spondylosis).
Methodology: A total of 64 patients will be enrolled, and they will be evenly divided into two groups. Modified Ashmaghnasveda will be performed for 14 days in GroupA(Interventional). Churnapindasveda will be performed for 14 days in GroupB (comparator group). Expected Results: The objective parameters will be monitored and documented as they change. Conclusion: Based on the information gathered, conclusions will be reached.
Low Back Pain among Preprimary and Primary School Teachers Affecting Their Activities of Daily Living (ADL’s): Questionnaire Based Study
Authors: Guhe Akshata , Sontake Prachi , Nagarkar Shiril , Jha Rakesh Kumar , Bankar Nandkishor 
Published: February 2022

Background: Low back pain is a complicated illness that is influenced by a variety of circumstances, making it difficult to pinpoint a single cause or even a major contributor. The yearly first-time incidence of low back pain is 5% and the annual prevalence ranges from 15 to 63 percent (those suffering at the time of diagnosis).
Objective: The study's goal is to find out how common low back pain is among preprimary and primary school teachers by analyzing questionnaire responses. Methods: A suitable sample approach was used to conduct a questionnaire-based cross-sectional study on 200 school instructors in diverse schools (Mother's pet kindergarten, mundle English medium, kinder joy, etc).
Results: The results revealed that preprimary and primary school teachers have a moderate level of low back discomfort, with an average score of 25.35 percent.
Conclusion: It also shows that there is a moderate increase in low back discomfort as one's working years grow.
A Healthcare Worker's Adverse Skin Reaction to the Use of Personal Protection Equipment and Frequent Hand Washing in COVID 19
Authors: Mulchandani Pankaj D. , Singh Sudhir , Suryawanshi Mihika , Nakade Mrunal , Vaidya Nikhil R. , Chandi Dhruba Hari 
Published: February 2022

Background: Due to the increasing number of covid 19 cases, HCWs must use personal protective equipment (PPE) such as N95 masks, latex gloves, and protective clothes due to the significant infectivity of COVID-19, which may cause unpleasant skin responses.
Materials and Methods: The Demographic data of 89 individuals, duration of work in covid facilities, history of skin pre-existing skin disease, information about personal protective kit used that is a type of mask used ( N95 with ear strap or head strap, FFP2, cloth mask, surgical mask), type of gloves used (nitrile, latex, rubber, plastic), frequency of hand washing and frequency of use of hand sanitizer and any adverse skin reaction seen by their use was collected from a participant who fulfilled the inclusion criteria by the distribution of questionnaires.
Results: Out of 89 individual, 73 individual showed adverse skin reactions to the use of mask, including nasal bridge scarring (10.11%), facial itching (19.10%), skin damage (4.49%), dry skin (12.36%), and rash (8.99%), acneiform eruption (7.87%), indentation and ear pain (11.24%). Facial itching was the most common adverse skin reaction in individuals using masks. Dry skin (28.08%) and Itching (17.97 %) were common adverse skin reactions. Twenty-nine individuals experienced adverse skin reactions to the use of PPE. The most common skin reactions were dry skin (12) and itching (10).
Conclusion: Due to the long-term use of PPE, masks, gloves, and adverse skin reactions, healthcare workers are prone to adverse skin reactions; a proper suggestion made that the use of cloth mask under N95 OR FFP2 mask can help reduce such adverse reactions.
Efficacy of Piroxicam and Tramadol as a Pre-Emptive Analgesic Agent for Mandibular Third Molar Surgery
Authors: Krishnan Sneha , Periasamy Senthilnathan , Kumar M. P. Santhosh 
Published: February 2022

Objectives: The purpose of this clinical trial is to examine the effectiveness of 20 mg piroxicam with 50 mg tramadol as a pre-emptive analgesic for mandibular third molar surgery.
Methods: In this prospective study, 30 patients were referred to the Department of Oral and Maxillofacial Surgery in Chennai for surgical removal of impacted mandibular third molars with similar difficulty indexes under local anesthetic. Patients were randomly distributed to one of two groups: Group A received 20 mg piroxicam intramuscularly (IM) 50 minutes before surgery, while Group B received 50 mg tramadol IM 50 minutes before surgery. The time to analgesic re-medication, Pain intensity (VAS Scores) at 1st, 2nd, 12th, 24th hour, total analgesic consumption was evaluated.
Results: When compared to the group getting 50 mg of tramadol IM, the group receiving 20 mg of piroxicam IM demonstrated differences in pain intensity as measured by the visual analog scale and total analgesic consumption [lesser values], and the results were statistically significant(p<0.05). However, there were no statistically significant differences between the two groups in terms of time to first rescue analgesic medication, number of patients requiring the rescue analgesic procedure (10 mg of oral ketorolac), and number of patients without the need for analgesic during the evaluation period. (P >0 .05).
Conclusion: Within the limits of the study, patients who received 20 mg of piroxicam before surgery had less pain intensity and total analgesic consumption than those who received 50 mg of tramadol before surgery. In comparison to pre-emptively administered tramadol, piroxicam showed superior analgesic effects for intermediate surgical operations when given preoperatively.