bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Rotation of Magnetic Flux Ropes Formed during Solar Eruption
Authors: Zhou 周 Zhenjun 振军 , Jiang Chaowei , Liu Rui , Wang Yuming , Liu Lijuan , Cui Jun 
Published: March 2022

Abstract
Eruptions of solar filaments often show rotational motion about their rising direction, but the mechanism governing such rotation, and how the rotation is related to the initial morphology of the preeruptive filament (and cospatial sigmoid), filament chirality, and magnetic helicity, remains elusive. The conventional view of rotation as a result of a magnetic flux rope (MFR) undergoing ideal kink instability still has difficulty explaining these relationships. Here we propose an alternative explanation for the rotation during eruptions by analyzing a magnetohydrodynamic simulation in which magnetic reconnection initiates an eruption from a sheared arcade configuration, and an MFR is formed during eruption via reconnection. The simulation reproduces a reverse-S-shaped MFR with dextral chirality, and the axis of this MFR rotates counterclockwise while rising, which compares favorably with a typical filament eruption observed from dual viewing angles. By calculating the twist and writhe numbers of the modeled MFR during its eruption, we found that, accompanied by the rotation, the nonlocal writhe of the MFR’s axis decreases while the twist of its surrounding field lines increases, and this is distinct from kink instability, which converts magnetic twist into the writhe of the MFR axis.
Research Infrastructure Contact Zones: a framework and dataset to characterise the activities of major biodiversity informatics initiatives
Authors: Smith Vincent , French Lisa , Vincent Sarah , Woodburn Matt , Addink Wouter , Arvanitidis Christos , Bánki Olaf , Casino Ana , Dusoulier Francois , Glöckler Falko , Hobern Donald , Kalfatovic Martin R. , Koureas Dimitrios , Mergen Patricia , Miller Joe , Schulman Leif , Juslén Aino 
Published: March 2022

The landscape of biodiversity data infrastructures and organisations is complex and fragmented. Many occupy specialised niches representing narrow segments of the multidimensional biodiversity informatics space, while others operate across a broad front but differ from others by data type(s) handled, their geographic scope and the life cycle phase(s) of the data they support. In an effort to characterise the various dimensions of the biodiversity informatics landscape, we developed a framework and dataset to survey these dimensions for ten organisations (DiSSCo, GBIF, iBOL, Catalogue of Life, iNaturalist, Biodiversity Heritage Library, GeoCASe, LifeWatch, eLTER, ELIXIR), relative to both their current activities and long-term strategic ambitions.
The survey assessed the contact between the infrastructure organisations by capturing the breadth of activities for each infrastructure across five categories (data, standards, software, hardware and policy), for nine types of data (specimens, collection descriptions, opportunistic observations, systematic observations, taxonomies, traits, geological data, molecular data, and literature), and for seven phases of activity (creation, aggregation, access, annotation, interlinkage, analysis, and synthesis). This generated a dataset of 6,300 verified observations, which have been scored and validated by leading members of each infrastructure organisation. The resulting data allows high-level questions about the overall biodiversity informatics landscape to be addressed, including the greatest gaps and contact between organisations.
Fantaisie livresque
Authors: Rosset Pierre 
Published: March 2022

Une nuit d’orage dans une bibliothèque d’un de nos EFTS (Établissement de formation de travailleurs sociaux) déclenche une aventure livresque dans laquelle des livres d’auteurs du passé offrent leurs plus belles pages pour élaborer « le livre des livres » à l’attention des étudiants de notre secteur.
Précocité, prématurité du moi. De la qualité des sublimations
Authors: Aisenstein Marilia 
Published: March 2022

À partir de la notion de précocité et de la « prématurité du moi » décrite par Michel Fain, l’auteur s’interroge sur les destins et la valeur fonctionnelle de la sublimation en relation avec la précocité/prématurité. Se fondant sur les travaux de Michel Fain, Benno Rosenberg et André Green, elle propose d’examiner la qualité de cette dernière et pose l’hypothèse d’un « négatif de la sublimation ». Résultant d’une désintrication pulsionnelle qui libère la pulsion de mort, ce « négatif de la sublimation » pourrait porter électivement la destructivité engendrée envers l’élément humain. Ceci induirait un pervertissement de certaines sublimations artistiques ou idéologiques qui dès lors iraient à l’encontre de l’idée freudienne, défendue en 1927, d’un Surmoi résultat d’une dialectique entre culturel et intrapsychique. En 1929, Freud décrit un « processus de civilisation » impliquant le sacrifice des satisfactions pulsionnelles au profit « d’une grande communauté humaine ».
L’aiguillon douloureux de la précocité
Authors: Chervet Emmanuelle 
Published: March 2022

L’auteur propose un retour sur la notion de masochisme dans l’œuvre freudienne et dans celle des psychosomaticiens. La différenciation entre masochisme érogène primaire et masochisme érotique ouvrant au fantasme par le double retournement pulsionnel permet un repérage transférentiel plus précis. C’est ainsi que prend sens la description des défenses anti-traumatiques actives et de la prématurité du moi, proches de ce qu’on décrit actuellement en termes de précocité. La polarité activité-passivité y disparaît au profit de l’activité. Il s’agit d’une conjoncture qui interdit la régression et l’investissement d’un pôle hallucinatoire par la réexcitation sans fin d’un accrochage aux perceptions nociceptives. La clinique d’un enfant « précoce » illustre la participation parentale à cette prématuration, et quelques modes possibles de son élaboration. L’accès au masochisme moral permet une issue du côté de la douleur morale, et la haine une issue agie qui ouvre cependant à une différenciation et à une séparation.
Le pare-excitation sur le divan de la psychothérapie psychanalytique corporelle
Authors: Ribour Walter 
Published: March 2022

Comment le pare-excitation défini par Freud comme ce tégument protecteur régulant le passage des excitations entre le dehors et le dedans trouve-t‑il sur « cet autre divan » de la psychothérapie psychanalytique corporelle un cadre favorisant son renforcement ? Par l’appui sur le perceptif et tout particulièrement par la mise en éveil de la fonction du toucher à distance, le patient au pare-excitation défaillant est porté et contenu par le divan, par « l’objet-analyste » en personne et par le tact de ce dernier, favorisant ainsi le traitement de l’excitation, son évacuation et sa liaison.
Qu’est-ce donc que le cadre ?
Authors: Bleger Leopoldo 
Published: March 2022

Depuis la fin des années quatre-vingt-dix, le cadre est devenu un thème de plus en plus présent dans le débat et dans la littérature psychanalytique. Auparavant, le mot en était absent ou utilisé par quelques psychanalystes comme un simple terme sans véritable conceptualisation. Le premier à en faire un concept a été D.W. Winnicott dans les années cinquante. Il faudra attendre la fin des années soixante pour que le concept soit traité en tant que tel. Ce fut le cas d’abord en Argentine par José Bleger et d’autres auteurs argentins. À partir des années soixante-dix, le concept commence à prendre une place de plus en plus importante en France, grâce surtout à Jean-Luc Donnet et André Green. Ce texte se limite aux premiers temps du surgissement du concept de cadre. Pourquoi la promotion de ce concept ? Pourquoi est-il devenu omniprésent dans les échanges entre analystes ? S’agit-il d’un approfondissement des problèmes de la cure psychanalytique, ou est-il au service de profonds changements de la technique ?
Élaboration groupale du contre-transfert au psychodrame psychanalytique individuel
Authors: Blanc Adrien , Boutinaud Jérôme 
Published: March 2022

Un des vecteurs thérapeutiques du psychodrame individuel réside dans la rencontre de plusieurs cliniciens au sein d’une expérience clinique partagée en groupe avec un unique patient. Radicalement différente des expériences de la cure individuelle, cette configuration pourrait apparaître comme portant le germe d’une possible confusion de par notamment le nombre de co-thérapeutes présents. Toutefois, si l’on considère qu’une élaboration groupale puisse s’effectuer autour de la dynamique transféro-contre-transférentielle induite par le patient accueilli, cette « cacophonie » potentielle peut déboucher sur une élaboration psychique qui trouvera son expression la plus aboutie au cœur même du jeu. Ouvrant sur une réflexion articulée autant par rapport au vécu clinique expérimenté dans la séance qu’aux élaborations qui l’accompagnent en périphérie, cet article montre comment le groupe vient à métaboliser les éléments transférentiels qui s’y déploient, modelant par la suite l’engagement de ses participants faisant une place aux contenus non-représentés.élaboration groupale, contre-transfert groupal, contenus non symbolisés, symbolisation, processus thérapeutique, espace transitionnel.
Sur les épaules de Marty. Le principe évolutionniste
Authors: Blanquer-Laguarta Albert 
Published: March 2022

Cet article est une recherche sur les bases évolutionnistes de l’œuvre de Pierre Marty. André Green l’a à juste titre questionné sur l’absence de références à l’origine de son œuvre. Pour Marty, l’évolutionnisme est un principe évident de sa vision de la psychosomatique transmis en premier par son père, Abel Marty. Après un rappel des théories de l’évolution, l’article passe en revue ses influences évolutionnistes, confirmées ou probables, et décrit comment sa pensée évolutionniste a progressé : sa thèse savante, sa prise de conscience des résistances face à ce principe, la description des chaînes évolutives, les fixations intra-utérines, l’élargissement des lois de l’inconscient grâce aux principes d’automation et programmation et son rapprochement du théoricien des sciences Henri Atlan. Dans son ouvrage de 1990, La psychosomatique de l’adulte, Marty signale les limites de ses découvertes au sujet du « choix » de pathologie et d’organe, objet d’une possible recherche évolutionniste.
Quelques figures littéraires de la migraine
Authors: Jaeger Philippe 
Published: March 2022

Nous avons découvert que la migraine était présentée, dans l’après-coup de la création littéraire, d’une manière riche et précise par les auteurs étudiés tous migraineux, comme G. Sand, G. de Maupassant, T. Ben Jelloun, P. M. Moller, Boulgakov et P. Fleutiaux. Leur description, particulièrement évocatrice du contexte dans lequel survient la crise, suggère souvent l’irruption imprévue d’un facteur de l’environnement désorganisant momentanément la vie psychique, conséquence d’une mise en danger du narcissisme primaire du sujet, là où le sujet fait partie de l’environnement et l’environnement du sujet. Il en résulte parfois la survenue d’angoisses de forte intensité. Le mécanisme psychique de la répression, qui désarticule affect et représentation précède parfois la crise. La migraine, transformée et élaborée par l’acte de création littéraire, permet de surmonter la blessure narcissique infligée. Il en résulte une restauration de l’espace transitionnel de jeu et de symbolisation momentanément détruit, l’auteur parvenant à communiquer, grâce à l’écriture, avec un objet intérieur et extérieur (le lecteur) son expérience émotionnelle de la crise, jadis non traduite en langage verbal.
Brain Science-Based Innovative Collaborative Teaching to Facilitate Nursing Education
Authors: Lee Amy S. D. , Rebecca Owings Clara , Johnson Jessica M. , Carruth Melissa S. 
Published: March 2022

Background:
Innovative teaching that effectively promotes learning is a process called brain science. Chemicals released during motivation and attention lead to improved learning, and chemicals released during high-stress situations deter learning. The coronavirus disease 2019 (COVID-19) pandemic has created unprecedented stress while providing an opportunity to create innovative strategies for facilitated learning.

Method:
To meet the pandemic challenges of a traditional undergraduate nursing program at a large state-funded university, specialty course faculty collaborated to redesign the courses using brain science concepts.

Results:
Students demonstrated improved average course scores across courses compared with previous students (obstetrics, 2%; pediatrics, 4.34%; and critical care, 1.38%). Overall student feedback was positive.

Conclusion:

Brain science provides the foundation for advanced education that promotes optimal learning. The stress of the COVID-19 pandemic has created the opportunity for the implementation of an advanced educational model in which learning is facilitated and supported.

[
J Nurs Educ
. 2022;61(3):162–166.]
Long-Lasting Virus-Specific T Cell Response with Divergent Features in Self-Resolved and Chronic Hepatitis C Virus Patients 35 Years Postinfection
Authors: Ji Wei , Zhao Min , Zhou Jikun , Zheng Huanwei , Li Naizhe , Han Bihua , Yin Wenjiao , Bi Shengli , Gao George F , Zhang Yong , Liu William J 
Published: March 2022

Abstract
Although recognized as a curable disease, the persistence of hepatitis C virus (HCV) in chronically infected patients remains a great burden for public health. T cell immune responses serve a key role in anti-HCV infection; however, the features of T cell immunity in patients after a long-term infection are not well explored. We recruited a special cohort of patients with similar genetic background and natural developing progression of disease who were infected with HCV through blood donation 35 y ago. We found that self-resolved individuals had higher levels of cytokine-secreting T cells than individuals with chronic infections, indicating HCV-specific T cell immunity could be sustained for &gt;35 y. Meanwhile, virus-specific CD8+ T cells in chronic patients were characterized by programmed cell death-1high, TIM-3high expression, which was related to liver injury characterized by aspartate transaminase/alanine aminotransferase levels and morphopathological changes. Unexpectedly, the expression of Lymphocyte-activation gene 3 on CD8+ T cells was lower in chronic patients and negatively correlated with alanine aminotransferase/aspartate transaminase. Our findings provided new insights into HCV-specific T cell responses and may shed light on a way to figure out novel effector targets and explore a way to reverse chronic infections.
Athletic Training Residency Program Development and Assessment of Advanced Clinical Reasoning
Authors: Hofmann Dyllan Wayne , Welch Bacon Cailee E. , Rivera Matthew J. , Eberman Lindsey E. 
Published: March 2022

Context
Clinical reasoning is an inferential process of collecting and evaluating data in patient cases, necessary in all care. Athletic training residency programs are emerging rapidly as the industry standard for developing clinical specialists who possess advanced clinical reasoning needed for complex cases.

Objective
The purpose of this study was to explore current practices of advanced clinical reasoning development and assessment in athletic training residency programs.

Design
Inductive qualitative research.

Setting
Web-based teleconferencing platform (Zoom Video Communications).

Patients or Other Participants
Seven of 10 Commission on Accreditation of Athletic Training Education–accredited residency program directors (RPDs) (age = 46 ± 9 years, years as RPD = 5 ± 6).

Data Collection and Analysis
We used qualitative, semistructured interviews. Audio files were transcribed verbatim, checked for accuracy, deidentified, and member checked before analysis. We used a 2-person data analysis team and an inductive coding approach. The researchers reviewed the transcripts independently, met to develop a codebook, applied the codes, and conducted internal auditing. Trustworthiness was established through member checking, multiple-analyst coding, and auditing.

Results
Three themes emerged from the RPDs about developing advanced clinical reasoning: (1) defining clinical reasoning, (2) instructional tactics, and (3) assessment tactics. RPDs defined clinical reasoning as the process of the resident justifying their decision-making and the accuracy of their decisions. RPDs described both clinical and didactic instructional tactics, including mentoring, lectures and discussions, case presentations, and journal club. RPDs described assessing advanced clinical reasoning through patient and preceptor feedback in structured and unstructured formats, self-reflection, and knowledge testing to measure clinical reasoning. RPDs highly relied on preceptors and clinical mentoring, but also described a singular reliance on residents to appraise the clinical reasoning capacity of their own preceptors.

Conclusions
RPDs define clinical reasoning as rationalization and accuracy of decisions. Although the programs are engaged in effective clinical and didactic approaches to teach advanced clinical reasoning, they rely heavily on the subjectivity of preceptors and residents to assess these outcomes.
Lentinula edodes extract inhibits matrix metalloproteinase expression and increases type I procollagen expression via the p38 MAPK/c-Fos signaling pathway in ultraviolet A and B-irradiated HaCaT keratinocytes
Authors: Lee Jung Im , Oh Jung Hwan , Karadeniz Fatih , Park So Young , Kim Hye Ran , Jo Hyun Jin , Jung Kyung Im , Jeon Byung-Jin , Kong Chang-Suk 
Published: March 2022

Objective:
To determine the effect of Lentinula edodes extract on ultraviolet (UV) A and UVB-induced changes in matrix metalloproteinase (MMP) and type I procollagen expression using human immortalized HaCaT keratinocytes.

Methods:

Lentinula edodes ethanol extract (LEE) was obtained by extraction with 80% ethanol for 4 h at 80 °C. Effect of LEE on UV-induced alteration on the expression and production of MMPs and type I procollagen in keratinocytes was investigated using ELISA, RT-PCR, and Western blotting assay. To determine the underlying mechanism of LEE-mediated effects, mitogen-activated protein kinase (MAPK) and activator protein 1 signaling pathways were analysed by Western blotting assay.

Results:
LEE significantly inhibited the expression of MMP-1 and MMP-9 and increased the expression of type I procollagen in UVA and UVB-irradiated HaCaT keratinocytes. The phosphorylation levels of p38 were significantly inhibited by LEE whereas it did not affect c-Jun N-terminal kinase and extracellular signal-regulated kinase phosphorylation. Suppression of p38 phosphorylation was also accompanied by downregulation of UVA and UVB-induced increase in c-Fos.

Conclusions:
LEE effectively inhibits the expression of MMP-1 and MMP-9 and increases type I procollagen production through the p38 MAPK/c-Fos signaling pathway in UVA and UVB-irradiated HaCaT keratinocytes. This findings suggest that Lentinula edodes may be developed as a cosmetic material to suppress UV exposuremediated skin aging.
Immunostimulatory effect of ethanol extract of Chondracanthus tenellus in RAW 264.7 macrophages in vitro
Authors: Park Cheol , Kwon Da Hye , Lee Hyesook , Hong Su Hyun , Kim Gi-Young , Cha Hee-Jae , Kim Do-Hyung , Kim Suhkmann , Kim Heui-Soo , Hwang Hye-Jin , Choi Yung Hyun 
Published: March 2022

Objective:
To investigate whether ethanol extracts of Chondracanthus tenellus (EECT) could improve immunomodulatory property of murine monocyte/macrophage RAW 264.7 cells.

Methods:
Cell viability, phagocytic ability, and nitric oxide were measured. The levels of prostaglandin E2 and cytokines were determined using enzyme-linked immunosorbent assay kits. Expression of immunoregulatory response protein was detected by Western blotting assay.

Results:
As the concentration of EECT increased, the morphology of the cells changed to a typical active macrophage shape, and the phagocytic activity increased significantly. EECT also effectively enhanced the production and secretion of immunomodulatory mediators, such as nitric oxide and prostaglandin E2, and cytokines. In addition, compared with the control group, EECT markedly stimulated the expression of Toll-like receptor 4 (TLR4) and myeloid differentiation factor 88, one of the TLR4 adapter molecules. Furthermore, EECT promoted the nucleus translocation of nuclear factor-kappa B (NF-κB) by increasing the phosphorylation and degradation of the inhibitor of NF-κB-α, indicating activation of the NF-κB signaling pathway. Meanwhile, similar trends were found in cells treated with lipopolysaccharide as a positive control.

Conclusions:
Taken together, the results indicate that EECT has an immunomodulatory effect by increasing the production of immunomodulatory mediators and cytokines through activation of the TLR4/NF-κB signaling pathway. EECT could be used as a potential candidate for medication or dietary supplements to increase immune activity.
Total flavonoids from Saussurea involucrata attenuate inflammation in lipopolysaccharide-stimulated RAW264.7 macrophages via modulating p65, c-Jun, and IRF3 signaling pathways
Authors: Yan Li-Shan , Wang Li , Cheng Brian Chi-Yan , Ding Yu , Kong Jing , Wang Qing Gao , Fu Xiu-Qiong , Zhang Shuo-Feng , Luo Gan , Zhang Yi 
Published: March 2022

Objective:
To investigate the anti-inflammatory effects of the total flavonoids from Saussurea involucrata on lipopolysaccharides (LPS)-stimulated murine RAW264.7 macrophages and explore its underlying mechanism of action.

Methods:
Total flavonoids from Saussurea involucrata were extracted using chromatographic column method. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. The production of nitric oxide was detected by Griess assay and the release of cytokines (IL-10 and TNF-α) and chemokines (MCP-1, MIP-1a, and CCL5/RANTES) was determined by ELISA to evaluate the anti-inflammatory activity of total flavonoids from Saussurea involucrata. Moreover, nuclear translocation of p65, c-Jun, and IRF3 was detected by immunofluorescence microscopy and Western blotting analysis was performed to determine the expression of related proteins.

Results:
Total flavonoids extracted from Saussurea involucrata were 751.5 mg/g and the content of rutin was 506.5 mg/g. The production of inflammatory mediators including nitric oxide, cytokines, and chemokines was effectively inhibited by total flavonoids from Saussurea involucrata. Meanwhile, total flavonoids also suppressed the nuclear translocation of p65, c-Jun, and IRF3 in LPS-stimulated RAW264.7 cells. The LPS-induced expression of iNOS and COX-2 was remarkably reduced by treatment with total flavonoids from Saussurea involucrata. Moreover, total flavonoids decreased the expression levels of p-IKKa/β, p-TBK1, p-p38, p-ERK, p-JNK, p-p65, p-c-Jun, and p-IRF3 in LPS-exposed RAW264.7 macrophages.

Conclusions:
Total flavonoids from Saussurea involucrata potentially inhibit the secretion of pro-inflammatory mediators, which may be related to inhibition of p65, c-Jun, and IRF3 signaling pathways in LPS-stimulated RAW264.7 cells.