bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell–Mediated Antitumor Immune Responses
Authors: Fedoriw Andrew , Shi Leilei , O'Brien Shane , Smitheman Kimberly N. , Wang Yunfei , Hou Jiakai , Sherk Christian , Rajapurkar Satyajit , Laraio Jenny , Williams Leila J. , Xu Chunyu , Han Guangchun , Feng Qin , Bedford Mark T. , Wang Linghua , Barbash Olena , Kruger Ryan G. , Hwu Patrick , Mohammad Helai P. , Peng Weiyi 
Published: April 2022

AbstractProtein arginine methyltransferases (PRMT) are a widely expressed class of enzymes responsible for catalyzing arginine methylation on numerous protein substrates. Among them, type I PRMTs are responsible for generating asymmetric dimethylarginine. By controlling multiple basic cellular processes, such as DNA damage responses, transcriptional regulation, and mRNA splicing, type I PRMTs contribute to cancer initiation and progression. A type I PRMT inhibitor, GSK3368715, has been developed and has entered clinical trials for solid and hematologic malignancies. Although type I PRMTs have been reported to play roles in modulating immune cell function, the immunologic role of tumor-intrinsic pathways controlled by type I PRMTs remains uncharacterized. Here, our The Cancer Genome Atlas dataset analysis revealed that expression of type I PRMTs associated with poor clinical response and decreased immune infiltration in patients with melanoma. In cancer cell lines, inhibition of type I PRMTs induced an IFN gene signature, amplified responses to IFN and innate immune signaling, and decreased expression of the immunosuppressive cytokine VEGF. In immunocompetent mouse tumor models, including a model of T-cell exclusion that represents a common mechanism of anti–programmed cell death protein 1 (PD-1) resistance in humans, type I PRMT inhibition increased T-cell infiltration, produced durable responses dependent on CD8+ T cells, and enhanced efficacy of anti–PD-1 therapy. These data indicate that type I PRMT inhibition exhibits immunomodulatory properties and synergizes with immune checkpoint blockade (ICB) to induce durable antitumor responses in a T cell–dependent manner, suggesting that type I PRMT inhibition can potentiate an antitumor immunity in refractory settings.
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
Authors: Heidenreich Paul A. , Bozkurt Biykem , Aguilar David , Allen Larry A. , Byun Joni J. , Colvin Monica M. , Deswal Anita , Drazner Mark H. , Dunlay Shannon M. , Evers Linda R. , Fang James C. , Fedson Savitri E. , Fonarow Gregg C. , Hayek Salim S. , Hernandez Adrian F. , Khazanie Prateeti , Kittleson Michelle M. , Lee Christopher S. , Link Mark S. , Milano Carmelo A. , Nnacheta Lorraine C. , Sandhu Alexander T. , Stevenson Lynne Warner , Vardeny Orly , Vest Amanda R. , Yancy Clyde W. 
Published: April 2022

Aim:
The “2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure” replaces the “2013 ACCF/AHA Guideline for the Management of Heart Failure” and the “2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure.” The 2022 guideline is intended to provide patient-centric recommendations for clinicians to prevent, diagnose, and manage patients with heart failure.

Methods:
A comprehensive literature search was conducted from May 2020 to December 2020, encompassing studies, reviews, and other evidence conducted on human subjects that were published in English from MEDLINE (PubMed), EMBASE, the Cochrane Collaboration, the Agency for Healthcare Research and Quality, and other relevant databases. Additional relevant clinical trials and research studies, published through September 2021, were also considered. This guideline was harmonized with other American Heart Association/American College of Cardiology guidelines published through December 2021.

Structure:
Heart failure remains a leading cause of morbidity and mortality globally. The 2022 heart failure guideline provides recommendations based on contemporary evidence for the treatment of these patients. The recommendations present an evidence-based approach to managing patients with heart failure, with the intent to improve quality of care and align with patients’ interests. Many recommendations from the earlier heart failure guidelines have been updated with new evidence, and new recommendations have been created when supported by published data. Value statements are provided for certain treatments with high-quality published economic analyses.
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
Authors: Heidenreich Paul A. , Bozkurt Biykem , Aguilar David , Allen Larry A. , Byun Joni J. , Colvin Monica M. , Deswal Anita , Drazner Mark H. , Dunlay Shannon M. , Evers Linda R. , Fang James C. , Fedson Savitri E. , Fonarow Gregg C. , Hayek Salim S. , Hernandez Adrian F. , Khazanie Prateeti , Kittleson Michelle M. , Lee Christopher S. , Link Mark S. , Milano Carmelo A. , Nnacheta Lorraine C. , Sandhu Alexander T. , Stevenson Lynne Warner , Vardeny Orly , Vest Amanda R. , Yancy Clyde W. 
Published: April 2022

Aim:
The “2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure” replaces the “2013 ACCF/AHA Guideline for the Management of Heart Failure” and the “2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure.” The 2022 guideline is intended to provide patient-centric recommendations for clinicians to prevent, diagnose, and manage patients with heart failure.

Methods:
A comprehensive literature search was conducted from May 2020 to December 2020, encompassing studies, reviews, and other evidence conducted on human subjects that were published in English from MEDLINE (PubMed), EMBASE, the Cochrane Collaboration, the Agency for Healthcare Research and Quality, and other relevant databases. Additional relevant clinical trials and research studies, published through September 2021, were also considered. This guideline was harmonized with other American Heart Association/American College of Cardiology guidelines published through December 2021.

Structure:
Heart failure remains a leading cause of morbidity and mortality globally. The 2022 heart failure guideline provides recommendations based on contemporary evidence for the treatment of these patients. The recommendations present an evidence-based approach to managing patients with heart failure, with the intent to improve quality of care and align with patients’ interests. Many recommendations from the earlier heart failure guidelines have been updated with new evidence, and new recommendations have been created when supported by published data. Value statements are provided for certain treatments with high-quality published economic analyses.
Synthetic Extracellular Volume in Cardiac Magnetic Resonance Without Blood Sampling: a Reliable Tool to Replace Conventional Extracellular Volume
Authors: Chen Wensu , Doeblin Patrick , Al-Tabatabaee Sarah , Klingel Karin , Tanacli Radu , Jakob Weiß Karl , Stehning Christian , Patel Amit R. , Pieske Burkert , Zou Jiangang , Kelle Sebastian 
Published: April 2022

Background:
The calculation of extracellular volume (ECV) in cardiac magnetic resonance requires hematocrit, limiting its applicability in clinical practice. Based on the linear relationship between hematocrit and blood T1 relaxivity, a synthetic ECV could be estimated without a blood sample. We aim to develop and test regression models for synthetic ECV without blood sampling in 1.5-T and 3.0-T scanners.

Methods:
A total of 1101 subjects who underwent cardiac magnetic resonance scanning with native and postcontrast T1 mapping and venous hematocrit within 24 hours were retrospectively enrolled. Subjects were randomly split into derivation (n=550) and validation (n=551) subgroups for each scanner. Different regression models were derived controlling for sex, field strength, and left ventricle/right ventricle blood pool and validated in the validation group. We performed additional validation analyses in subgroups of patients with histological validation (n=17), amyloidosis (n=29), anemia (n=185), and reduced ejection fraction (n=322).

Results:

In the derivation group, 8 specific models and 2 common estimate models were derived. In the validation group, using specific models, synthetic ECV had high agreement with conventional ECV (R
2
, 0.87;
P
<0.0001 and R
2
, 0.88,
P
<0.0001; −0.16% and −0.10%, left ventricle and right ventricle model, respectively). Common models also performed well (R
2
, 0.88;
P
<0.0001 and R
2
, 0.89,
P
<0.0001; −0.21% and −0.18%, left ventricle and right ventricle model, respectively). Histological validation demonstrated equal performance of synthetic and measured ECV. Synthetic ECV as calculated by the common model showed a bias in the anemia cohort significantly reduced by the specific model (−2.45 to −1.28, right ventricle common and specific model, respectively).

Conclusions:
Synthetic ECV provided a promising way to calculate ECV without blood sampling. Specific models could provide the most accurate value, while common models could be more suitable in routine clinical practice because of their simplicity while maintaining adequate accuracy.
Testing, Teacher Turnover, and the Distribution of Teachers Across Grades and Schools
Authors: Fuchsman Dillon , Sass Tim R. , Zamarro Gema 
Published: April 2022

Abstract
Teacher turnover has adverse consequences for student achievement and imposes large financial costs for schools. Some have argued that high-stakes testing may lower teachers’ satisfaction with their jobs and could be a major contributor to teacher attrition. In this paper, we exploit changes in the tested grades and subjects in Georgia to study the effects of eliminating high-stakes testing on teacher turnover and the distribution of teachers across grades and schools. To measure the effect of testing pressures on teacher mobility choices we use a difference-in-differences approach, comparing changes in mobility over time in grades/subjects that discontinue testing vis-à-vis grades/subjects that are always tested. Our results show that eliminating testing did not have an impact on the likelihood of leaving teaching, moving between districts, changing schools within a district, or changing grades. Our findings hold for all teachers as well as for the subsample of early career teachers.
The Widening Global Network of Indonesian Diaspora Scholars in Malaysia
Authors: Sari Betti Rosita , Maunati Yekti , Wuryandari Ganewati , Lamijo  
Published: April 2022

Abstract
The paper discusses the global network for Indonesian diaspora scholars who work in Malaysian tertiary education, an emerging Asian education hub. The study is based on documents, text reviews, interviews, and reflections from Indonesian diaspora scholars. Our analysis identified three main themes: building academic success, brain circulation, and contributing to development in the country of origin. The analysis indicates that the interplay between the quality of human diaspora capital and Malaysian policies on higher education has shaped the academic success stories of Indonesian diaspora scholars in Malaysia. Although the Indonesian diaspora scholars in Malaysia have generated brain drain debates, the findings show that while Indonesian scholars continue to work in Malaysia, they also exercise their global networks as sources of human capital and knowledge to assist their home country.
Schopenhauer, Existential Negativity, and Buddhist Nothingness
Authors: Nelson Eric S. 
Published: April 2022

Abstract
Hegel remarked in his discussion of the nothing in the Science of Logic that: “It is well known that in oriental systems, and essentially in Buddhism, nothing, or the void, is the absolute principle.” Schopenhauer commented in a discussion of the joy of death in The World as Will and Representation: “The existence which we know he willingly gives up: what he gets instead of it is in our eyes nothing, because our existence is, with reference to that, nothing. The Buddhist faith calls it Nirvana, i.e., extinction.” It is striking how nineteenth-century German philosophical discourses (from Hegel and Schopenhauer to Mainländer, von Hartmann, and Nietzsche) concerning negativity, nihility, and nothingness explicitly refer to Buddhism, which was initially conceived by Christian missionaries as a “cult of nothingness” and became entangled with European debates concerning pessimism (the Pessimismusstreit) and nihilism. In this article, I reconsider how the interpretation of negativity and nothingness in Schopenhauer and nineteenth-century German thought informed the reception of Buddhism as a philosophical and religious discourse, and trace the ways in which Buddhist emptiness was reinterpreted in the context of the Western problematic of being and nothingness.
Dao as You? Dropping Proper Parthood in a Mereological Reconstruction of Daoist Metaphysics
Authors: Banka Rafal 
Published: April 2022

Abstract
In this article, I discuss parthood status in mereologically interpreted Daoist metaphysics, based on the Daodejing. I depart from the dao and you interrelation, which mereologically overlap by sharing parts. I consider the case of a complete overlap, which (a) challenges proper parthood, according to which a part cannot be identical with the whole that it composes, and (b) entails the question of identity that, while complying with classical mereology, cannot be consistent with Daoist metaphysics. The discussion leads to abandoning proper parthood and antisymmetry axiom from classical axiomatics. It also shows a plausible further direction for mereological reconstruction.
Contact call acoustic structure is associated with inter-individual distances during antiphonal vocal exchanges in wild red-tailed monkeys (Cercopithecus ascanius schmidti)
Authors: McLester Edward 
Published: April 2022

Abstract
Contact calls allow animals to maintain group cohesion when visibility is restricted. To maximise call detection, animals should produce calls that are audible to closest neighbours or respond to individuals that produce preceding calls (i.e., antiphony). Antiphonal exchanges are more likely to occur between older conspecifics that respond more reliably or close neighbours that are more likely to detect calls when groups are travelling. Because animals should produce calls that are optimised for propagation, call structure should be associated with the distance between individuals calling in antiphonal exchanges. I investigated whether acoustic structures of red-tailed monkey (Cercopithecus ascanius) contact calls (phrased grunts) reflected increased sound propagation as nearest neighbour distances increased, depending on three factors: (1) the occurrence of a preceding grunt, (2) neighbour age-sex class, and (3) group travel speed. I recorded grunts from five habituated monkey groups at Kibale National Park, Uganda. Per grunt, I measured five parameters associated with sound propagation. Grunt mean entropy and frequency related negatively to neighbour distance when the neighbour produced a preceding grunt or when there was no preceding grunt, but not when a more distant individual grunted prior. Neighbour age-sex class and group travel speed did not influence whether grunt structure was associated with neighbour distance, but monkeys produced grunts with higher mean entropy and frequency as groups travelled faster. Variation in grunt mean entropy and frequency was associated with propagation to either nearest neighbours or more distant individuals that produced preceding calls, providing quantitative evidence for antiphonal calling. By calling antiphonally, animals in cohesive groups can spread out to avoid intra-group competition while maintaining contact with other group members. Higher grunt entropy and frequency as groups travel faster may counteract more variable sound attenuation as animals move through acoustically complex (e.g., densely vegetated) environments.
Displaced People and Public Mercy: A Theological Account
Authors: Teklu Theodros Assefa 
Published: April 2022

Abstract
Place shapes people (who will in turn shape it); it reveals the contextual nature of religions and their theologies, implying that certain phenomena can have a disruptive impact on the theological domain, rendering it an on-going reflective enterprise. In this article I seek to construct a public theology that responds to the disruption of displacement. To this end, I rehearse some of the theoretical considerations on the precarious nature of the human condition of displacement in order to appraise its disruptive potential. Then I draw on Gregory of Nyssa’s homilies on almsgiving to generate a theological account of public mercy that addresses itself to this condition of displacement. Finally, I will accentuate the desirability of mercy as a public virtue, arguing that its decline in contemporary public life and the diminishing consensus on its meaning in current scholarly discourses is disastrous.
Time and Space in the Kingdom of God: Exploring Bonhoeffer’s Worldly and Earthly Christianity in the Anthropocene
Authors: Rayson Dianne 
Published: April 2022

Abstract
This article considers Bonhoeffer’s treatment of time and space and their relationship to worldly Christianity, and asks how this might be important for life in the Anthropocene. It engages with time and space via aspects of several of his texts including his first published monograph, Creation and Fall: A Theological Exposition of Genesis 1–3 (1937) delivered as the ‘Creation and Sin’ lectures at the University of Berlin through 1932–33; the short lecture, “Thy Kingdom Come: The Prayer of the Church-Community for God’s Kingdom on Earth” (19 November 1932); as well as his Ethics (incomplete manuscripts from 1940–43). It applies these findings to Bonhoeffer’s notion of worldly Christianity. In doing so, it pursues a contemporary development of worldly Christianity in the form of Earthly Christianity, one suitable for the demands of the new age, the Anthropocene, characterised by disruption, dissociation with the world, and a loss of hope.
Process and Mutually Enticing Opportunity as an Explanation for the US-China Trade War Negotiations
Authors: Wichterman Jenna 
Published: April 2022

Abstract
The US-China trade war lasted for two years, resulting in a volatile environment for multinational businesses and exacerbating already heated Sino-American political tensions. Despite all the uncertainty it produced, the Phase One trade agreement was an economic ceasefire and not a negotiated agreement that resolved core issues in the Sino-American trade relationship. The US-China trade war negotiations failed to yield a successful negotiated agreement addressing core bilateral trade issues largely due to a mutually enticing opportunity to produce a ceasefire rather than address core issues, and process failures. The United States failed to collect information and apply expert advice in the diagnostic stage; both parties failed to establish a negotiation formula; and the US lacked an authoritative spokesperson. This led to a nearly-wasted two years of negotiations, which concluded with the Phase One trade deal declared in January 2020 due to both sides’ perception of a mutually enticing opportunity.
L’histoire de Delphes et les Asclépiades
Authors: Jouanna Jacques 
Published: April 2022

Abstract
The object of this communication is to contribute to a rehabilitation of the Presbeutikos of Hippocrates generally considered since Littré as a legendary writing on the life of Hippocrates. Since Littré, the archaeological and epigraphic discoveries on Delphi have provided the Presbeutikos with anchoring points in reality. Three stages were important : a first, dating from the first half of the 20th century, due to Hans Pomtow, a second in the second half of the 20th century, due to Jean Bousquet and a third stage at the start of the 21st century due to Denis Rousset. These advances due to archaeologists must be put in relation with the advances of philologists which are not negligible either on the edition of the Presbeutikos after Émile Littré, in particular by the examination of the Ionian vocabulary of this speech including the rare words, which are hapax in the Hippocratic Corpus and are also attested in Herodotus. The language of Presbeutikos, by its antiquity, differs from that of more recent Letters.
Standard of Review in Indirect Expropriation: Reconciling the Effect Rule with the Doctrine of Intent
Authors: Ajibo Collins C. , Oguejiofor Chikodili O. , Egbom Chidi C. , Onyia Gloria I. , Okwulehie Iwu Victor E. , Nkokelonye Adaeze J. 
Published: April 2022

Abstract
The standard of review that underpins investor-state dispute resolution particularly in the energy and natural resources sectors remains mired in a conundrum of legitimacy. While the jurisprudence of arbitral tribunals illustrates that the effect doctrine constitutes the central standard of review, and the intent behind the measure is largely jettisoned, questions remain as to whether the exclusive reliance on the effect doctrine reflects the interest of both parties and actually balances such interests in such strategic sectors as oil and gas where a trade-off is critical in view of massive State reliance on accrued revenue. In essence, it is contended that the doctrine of intent be deployed to complement the effect doctrine. Such an approach will not only enhance the substantive legitimacy of the dispute settlement process but equally reflect the balanced interest emblematic of the proportionate commitment of both parties.
The Journal of the Galliot Nieuwer Amstel
Authors: van den Hout Julie , Jacobs Jaap , Dewulf Jeroen 
Published: April 2022

Abstract
In February 1660, supercargo Laurens de Sille sailed from New Amsterdam (Manhattan) to Curaçao aboard the galliot Nieuwer Amstel. Tasked with maintaining a record of the cargo, De Sille kept a journal of the four-month journey to Curaçao and back. While keeping a journal was common practice on Dutch ships, few survive from the seventeenth century. De Sille’s journal offers a unique insight into mid-seventeenth-century shipping activities at Curaçao, as his account captures day-to-day proceedings during a period for which there are only sparse extant sources on the island’s history. More importantly, De Sille’s chronicle of his two-month stay on the island depicts Curaçao as it emerged as a hub for the Dutch transatlantic slave trade.
Migrant Identity and Culture Maintenance: The Welsh in Columbus, Franklin County, Ohio, 1870–1930
Authors: Tyler Robert Llewellyn 
Published: April 2022

Abstract
This paper identifies the Welsh as a distinct ethno-linguistic community in the city of Columbus, Franklin County, Ohio during the late decades of the nineteenth century and the early decades of the twentieth. The paper analyses the nature of the Welsh community in the city, assesses the extent of involvement in its cultural expression, and considers socioeconomic improvement as indicated by occupational change. Further, the study considers culture maintenance, and suggests that Welsh ethnic integrity was undermined by a variety of forces, primarily: occupational diversity, bilingualism, high levels of exogamy, and the cessation of immigration from Wales. The article further posits that assimilation was aided by the desire of the Welsh to enter mainstream American society, with some actively abandoning their Old-World characteristics, and the host society’s perception, strongly promulgated by Welsh community leaders, that they were ideal immigrants.