bluuebunny/crossref_metadata_2025_split huggingface dataset:
A double-blind, randomized, placebo-controlled, single-center clinical trial of jiaotaiwan for the treatment of insomnia symptoms caused by disharmony of the heart and kidney
Authors: Xia Nengzhi , Jiang Chengrou , Zhou Yiwei , Huang Qun , Hu Lufeng , Zeng Haihuan , Luo Lin , Yuan Zhengzhong 
Published: November 2022

Background: Jiaotaiwan (JTW) is a classical tranquillizing prescription in traditional Chinese medicine (TCM) for the treatment of insomnia symptoms caused by disharmony of the heart and kidney (ISDHK). This study aimed to evaluate the effectiveness and safety of JTW for treating ISDHK in a double-blind, randomized, placebo-controlled trial.Methods: From September 2018 to February 2020, 128 participants with ISDHK were included in this single-center clinical trial. All participants were equally and randomly divided into either the JTW group (2-g JTW granules, b.i.d. for 7 days) or placebo group (2-g placebo granules, b.i.d. for 7 days). Pittsburgh Sleep Quality Index (PSQI) scores were set as the primary outcome, and polysomnography (PSG), 1H-magnetic resonance spectroscopy (1H-MRS), blood tests, and Disharmony of Heart and Kidney Scoring System (DHKSS) and clinical global impression (CGI) scores were used as secondary outcomes. Laboratory tests were used to evaluate the safety of JTW. All data were collected at baseline and posttreatment.Results: A total of 106 participants completed this clinical trial. Symptom relief was more apparent in the JTW group than the placebo group (PSQI total score: 9.34 ± 3.578 vs. 10.98 ± 3.073, respectively; p = 0.006). However, no PSG changes were observed between the two groups (p &gt; 0.05). Higher CGI and lower DHKSS scores were observed after JTW treatment. Serum melatonin was increased in patients with ISDHK after JTW treatment (JTW, 339.09 ± 256.894 vs. placebo, 219.59 ± 169.045; p = 0.004). There were significant posttreatment differences in metabolites in the left cerebellum between the two groups (myoinositol: JTW, 13.47 ± 2.094 vs. placebo, 12.48 ± 2.449; p = 0.021; choline: JTW, 3.96 ± 0.657 vs. placebo, 3.65 ± 0.562; p = 0.008). In terms of safety, JTW had no noticeable adverse effects relative to placebo.Conclusion: JTW was effective and well tolerated for the treatment of ISDHK. The development of large-scale trials with longer follow-up durations is recommended to provide further evidence.Clinical Trial Registration:clinicaltrials.gov, identifier ChiCTR1800019239
Acne caused by ziprasidone in a young patient with bipolar disorder: A case report
Authors: Yuan Yiwen , Li Xiaoqing , Jiang Xingmei , Li Zhixiong , Ou Ying , Li Zhe 
Published: November 2022

BackgroundZiprasidone is a second-generation antipsychotic drug commonly used to treat schizophrenia and bipolar disorder. Acne is a common inflammatory disease of sebaceous glands in adolescents that is often co-morbid with anxiety and depression, which may reduce treatment compliance. Through unknown mechanisms, ziprasidone may cause a range of inflammatory responses. Whether ziprasidone can cause acne in young patients with bipolar disorder has not been reported.Case summaryWe report a 23-year-old woman with a 5-year history of bipolar disorder who experienced acne during use of ziprasidone. She was admitted to our hospital during 1-month aggravation of her symptoms and was diagnosed with bipolar I disorder (current or most recent episode of depression) with psychotic features. She was given ziprasidone and soon developed acne, which she never had before; the rash worsened substantially when the ziprasidone dose was increased. At the same time, levels of inflammatory factors increased. The rash resolved after ziprasidone therapy was stopped.ConclusionWhen prescribing ziprasidone to young people with bipolar disorder, clinicians should consider the potential for adverse skin reactions. It may be useful to assay levels of inflammatory markers during ziprasidone therapy and adjust the dose if necessary in order to ensure treatment compliance.
Effect of physical activity on prevention of postpartum depression: A dose-response meta-analysis of 186,412 women
Authors: Yuan Mengqi , Chen Hongyang , Chen Dongmei , Wan Donggui , Luo Fan , Zhang Chenyang , Nan Yunxin , Bi Xiaoning , Liang Jing 
Published: November 2022

BackgroundPhysical activity (PA) is considered a favorable preventive intervention for postpartum depression (PPD), but evidence defining a corresponding dose-response relationship is lacking. This meta-analysis was conducted to assess the protective effects of PA on PPD and define a potential dose-response relationship between them.MethodsPubMed, Medline, Embase, and Web of Science were searched from 1968 to May 2022. Only randomized control trials (RCTs) and prospective studies were considered, and the PICOS tool was used to identify eligible articles based on the inclusion and exclusion criteria. Effect-size estimates were unified as odds ratio (OR) and 95% confidence interval (CI). We calculated the ORs and their 95% CI for studies that did not report them using the Practical Meta-Analysis Effect Size Calculator.ResultsA total of 23 studies were eligible, including 14 RCTs and 9 prospective cohort studies. The overall analysis showed a statistically significant positive association between PA and PPD prevention (adjusted OR = 0.73; 95% CI: 0.61–0.87; P &lt; 0.001). Subgroup analyses indicated that studies conducted in Europe demonstrated a significant correlation between PA and reduced PPD risk (adjusted OR = 0.85, 95% CI: 0.76–0.95, P = 0.004). Concerning PA type, sports activity was associated with relieving PPD symptoms (adjusted OR = 0.89, 95% CI: 0.78 to 1.00, P &lt; 0.001), while work (adjusted OR = 1.05, 95% CI: 0.37–2.97, P = 0.065) and household activities (adjusted OR = 1.16, 95% CI: 0.89–1.52, P = 0.986) contributed to a greater risk of PPD. Our dose-response analysis revealed a reverse J-shaped trend between ascending PA duration and PPD incidence.ConclusionThis meta-analysis identified PA as a potential intervention to reduce the risk of PPD. The dose-response analysis revealed that at least 90 min of PA per week could efficiently decrease the risk of PPD.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42022335731.
Risk perception of COVID-19 among college students in China: Latent profile analysis
Authors: Ren Juanjuan , Zhang Zhenxiang , Mei Yongxia , Wang Wenna , Sun Qianqian , Wang Mingxu , Hui Zhaozhao 
Published: November 2022

BackgroundThe outbreak of the new coronavirus-2019 (COVID-19) has had a significant impact on people's mental and physical health. Meanwhile, people's perceptions of risk may influence their emotional states and preventative behavior during an epidemic. Previous research have revealed the diversity and uniqueness of risk perception, and college students may have a different perspective on risk perception. The objective of this study was to describe the subtypes of risk perception for COVID-19 among college students in China, identify the subtypes' traits, and investigate their affecting variables.MethodsCollege students from 10 Chinese provinces participated in a cross-sectional study (n = 2,000) that from January 16 to 30, 2022. The latent profiles and influencing factors for risk perception were investigated using latent profile analysis, one-way analysis of variance, and multinomial logistical regression.ResultsThe sample group of this survey was 1,946 students, and the response rate was 97.3%. The best model was suggested to consist of three profiles: “neutral risk perception” (20.3%), “perception seriously without susceptible” (52.8%), and “low risk perception” (26.9%). Risk perception of COVID-19 was positively associated with attention to negation information (r = 0.372, p &lt; 0.01), anxiety (r = 0.232, p &lt; 0.01), and depression (r = 0.241, p &lt; 0.01), and negatively associated with perceived social support (r = −0.151, p &lt; 0.01). Logistic-regressions analyses mainly revealed that the risk perception of three profiles related to having chronic diseases (OR = 2.704, p &lt; 0.01), medical major (OR = 0.595, p &lt; 0.01; OR = 0.614, p &lt; 0.05), without having COVID-19 confirmed cases around (OR = 0.539, p &lt; 0.01), attention to negative information (OR = 1.073, p &lt; 0.001; OR = 1.092, p &lt; 0.001), and perceived social support (OR = 0.0.975, p &lt; 0.01).ConclusionsThe level of risk perception for COVID-19 among Chinese college students was unsatisfactory, and the risk perception of COVID-19 had significant group characteristics and heterogeneity. Colleges and public health practitioners could have a theoretical and empirical basis to implement risk perception intervention efforts by identifying latent subgroups during the COVID-19 epidemic.
Resilience resources and coping strategies of COVID-19 female long haulers: A qualitative study
Authors: Aghaei Atefeh , Aggarwal Abhishek , Zhang Ran , Li Xiaoming , Qiao Shan 
Published: November 2022

BackgroundFemale long haulers deal with persistent post-acute COVID-19 symptoms that have serious health implications. This study aimed to identify resilience resources at multiple socio-ecological levels for female long haulers and describe how resilience resources affect their responses to long COVID.MethodsPurposive sampling was adopted to recruit participants through social media from April to June 2021 followed by 15 semi-structured interviews. An inductive analytical approach was adopted to categorize themes by open and axial coding that were verified by peer review.ResultsFemale long haulers relied on resources at various socio-ecological levels to foster their resilience in response to long COVID. At the individual level, they utilized cognitive and emotional resources to increase knowledge, learn new skills, set goals, and manage emotions; behavioral resources (e.g., internal motivation and executive functioning) to perform physical, creative, and recreational activities, and adopt healthier eating habits; and spiritual resources to perform spiritual rituals and connect with God. At the social level, the support from existing relationships and/or online social support groups enhanced their social identity and provided material and informational resources. At the health systems level, the guidance from counselors and physicians and availability of clinics, medicines, and health equipment assisted them in symptom management and medication adherence.ConclusionThe resilience of female long haulers can be enhanced through (1) offering financial and health-related resources, (2) developing online social-support groups, (3) counseling and care service training for healthcare professionals, and (4) implementing more psychosocial interventions by labor organizations.
Relationship Between Occupational Noise and Hypertension in Modern Enterprise Workers: A Case–Control Study
Authors: Zhou Bo , Lan Yueyan , Bi Yifei , Li Chaoxiu , Zhang Xiaohong , Wu Xiaomei 
Published: November 2022

Objective: The association between occupational noise exposure and hypertension is controversial. Thus, we aimed to assess the relationship between occupational noise exposure and hypertension.Methods: This was a case‒control study, and 509 cases and 1,018 controls from an automobile company were included between July and October 2013. Occupational noise exposure was defined as exposure to noise level ≥80 dB(A) (Lex, 8 h) or cumulative noise exposure (CNE) ≥ 80 dB(A)-years. To assess the associations of noise level and CNE with hypertension, univariate and multivariate logistic regression were performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs). The restricted cubic spline function was used to establish dose‒response curves.Results: A noise level ≥80 dB (A) (Lex, 8 h) was significantly associated with hypertension (OR 2.48, 95% CI 1.89–3.24). CNE ≥80 dB (A)-years was significantly associated with hypertension (OR 1.53, 95% CI 1.18–2.00). Nonlinear relationships between noise level, CNE and hypertension were found (p- nonlinear&lt;0.05).Conclusion: Our study suggests that occupational noise exposure is a potential risk factor for hypertension in automobile company workers.
Genome-Wide Identification, Structural Characterization, and Gene Expression Analysis of BES1 Transcription Factor Family in Tartary Buckwheat (Fagopyrum tataricum)
Authors: Gao Anjing , Weng Wenfeng , Yao Xin , Wu Weijiao , Bai Qing , Xiong Ruiqi , Ma Chao , Cheng Jianping , Ruan Jingjun 
Published: November 2022

The transcription factor (TFs) BES1, which mediates brassinosteroid (BR) signaling, regulates plant growth and development. However, BES1 genes have not yet been reported in Tartary buckwheat. Here, ten FtBES1 genes were identified in the Tartary buckwheat genome, and they were named FtBES1-1 to FtBES1-10. These genes were divided into four groups according to the classification in Arabidopsis thaliana. Multiple sequence alignment indicated that all BES1 gene members contained the BES1_N structural domain. Phylogenetic relationship FtBES1 genes in the same group had similar gene structures and motifs. An analysis of cis-acting elements demonstrated that the BES1 TFs contains many light-responsive, hormonal, and abiotic stress-responsive elements, etc. The 10 FtBES1 genes were located on four chromosomes of Tartary buckwheat, and gene distribution and synteny analysis revealed that segmental duplications have played important roles in FtBES1 gene family expansion. Tissue specificity revealed that all of the ten FtBES1 members expressed highly in two periods, and relatively high expression levels were observed in mature leaves. Gene expression profiles under different hormone treatments demonstrated that FtBES1 gene family participated in the hormone stress response. This study enriches our knowledge of the Tartary buckwheat BES1 gene family and provides a theoretical basis for analyzing the biological functions and stress tolerance mechanisms of the Tartary buckwheat BES1 transcription factors.
Towards an Efficient Multi-Generation System Providing Power, Cooling, Heating, and Freshwater for Residential Buildings Operated with Solar-Driven ORC
Authors: Almehmadi Fahad Awjah , Elattar Hassan Fawzy , Fouda Ali , Alqaed Saeed , Alharthi Mathkar A. , Refaey Hassanein Abdelmohsen 
Published: November 2022

In buildings, multi-generation systems are a promising technology that can replace discrete traditional energy production methods. A multi-generation system makes it possible to efficiently produce electricity, cooling, heating, and freshwater simultaneously. This study involved the numerical analysis of a modified proposed novel solar-driven multi-generation system (MGS-II) integrated with the Organic Rankine Cycle (ORC), Humidification–Dehumidification Desalination System (HDH), and Desiccant Cooling System (DCS) by using heat recovery and thermal energy storage (TES) units. In addition, a comparison study with the basic multi-generation system (MGS-I) is performed. The proposed system is designed to supply electricity, air conditioning, domestic heating, and fresh water to small/medium-sized buildings. How operating conditions affect system productivity and performance metrics have been investigated. The results show that the proposed multi-generation system (MGS-II) can produce electrical power, space cooling, domestic heating and fresh water while maintaining comfortable conditions inside the conditioned space. Moreover, the MGS-II outperforms the MGS-I system, and the maximum MGS-II system productivity; electricity production (\({W_{net}^{\bullet}}\)), freshwater (\({m_{fresh}^{\bullet} }\)), space cooling (\({Q_{cooling}^{\bullet} }\)), and domestic heating (\({Q_{heating}^{\bullet} }\)) are 102.3 kW, 141.5 kg/h, 20.77 kW, and 225 kW, respectively. In addition, the highest total gained output ratio (TGOR), specific total gained energy (STG), and specific total gained energy equivalent price (STGP) of the MGS-II system are 0.6303, 3.824 kWh/m2, and 0.149 USD/m2, respectively. The accepted ranges of comfortable space-supplied air conditions (temperature and humidity) are 15.5–18.2 °C and 9.2–12.00 gv/kga for both systems, MGS-I and MGS-II. Finally, the current system (MGS-II) has the maximum of the system’s performance indicators and productivity (TGOR and \({{\overset{.}{m}}_{fresh} }\)) compared with the other reported systems.
The AP2 Transcription Factor BrSHINE3 Regulates Wax Accumulation in Nonheading Chinese Cabbage
Authors: Huo Zhaoyan , Xu Yang , Yuan Song , Chang Jiang , Li Shuhao , Wang Jinwei , Zhao Huanhuan , Xu Ru , Zhong Fenglin 
Published: November 2022

Wax is an acellular structural substance attached to the surface of plant tissues. It forms a protective barrier on the epidermis of plants and plays an important role in resisting abiotic and biotic stresses. In this paper, nonheading Chinese cabbage varieties with and without wax powder were observed using scanning electron microscopy, and the surface of waxy plants was covered with a layer of densely arranged waxy crystals, thus differentiating them from the surface of waxless plants. A genetic analysis showed that wax powder formation in nonheading Chinese cabbage was controlled by a pair of dominant genes. A preliminary bulked segregant analysis sequencing (BSA-seq) assay showed that one gene was located at the end of chromosome A09. Within this interval, we identified BraA09000626, encoding an AP2 transcription factor homologous to Arabidopsis AtSHINE3, and we named it BrSHINE3. By comparing the CDS of the gene in the two parental plants, a 35 bp deletion in the BrSHINE3 gene of waxless plants resulted in a frameshift mutation. Tissue analysis showed that BrSHINE3 was expressed at significantly higher levels in waxy plant rosette stage petioles and bolting stage stems than in the tissues of waxless plants. We speculate that this deletion in BrSHINE3 bases in the waxless material may inhibit wax synthesis. The overexpression of BrSHINE3 in Arabidopsis induced the accumulation of wax on the stem surface, indicating that BrSHINE3 is a key gene that regulates the formation of wax powder in nonheading Chinese cabbage. The analysis of the subcellular localization showed that BrSHINE3 is mainly located in the nucleus and chloroplast of tobacco leaves, suggesting that the gene may function as a transcription factor. Subsequent transcriptome analysis of the homology of BrSHINE3 downstream genes in nonheading Chinese cabbage showed that these genes were downregulated in waxless materials. These findings provide a basis for a better understanding of the nonheading Chinese cabbage epidermal wax synthesis pathway and provide important information for the molecular-assisted breeding of nonheading Chinese cabbage.
Anti-Inflammatory Effect of Korean Propolis on Helicobacter pylori-Infected Gastric Mucosal Injury Mice Model
Authors: Song Moon-Young , Lee Da-Young , Han Young-Min , Kim Eun-Hee 
Published: November 2022

Propolis, a natural resinous substance obtained from a variety of buds and plants, has been reported to possess various biological functions. Several recent studies have demonstrated the inhibitory effects of propolis on the growth of Helicobacter pylori (H. pylori) in vitro; however, current research efforts on Korean propolis (KP) remain insufficient especially in vivo. Our study aims to investigate the anti-inflammatory effect and molecular mechanism of KP on mouse gastric mucosa during H. pylori infection. We examined an in vivo H. pylori-induced gastric mucosal injury mice model. We found that KP inhibited the growth of H. pylori and attenuated the expression of H. pylori virulence factors such as cytotoxin-associated gene A, encoding urease A subunit, surface antigen gene and neutrophil-activating protein A. Moreover, KP reduced both gross lesions and pathological scores in H. pylori-challenged mice. In addition, KP markedly restrained the production of pro-inflammatory cytokines and nitric oxide levels compared with an untreated H. pylori-infected group. In particular, we found that KP repressed the phosphorylation of IκBα and NF-κB p65 subunit, and subsequently suppressed their downstream target genes. Taken together, these findings demonstrate the beneficial effects of KP on inflammation through the inhibition of NF-κB signaling as well as inhibition of H. pylori growth in a mouse model infected with H. pylori. This suggests the potential application of KP as a natural supplement for patient’s suffering from gastric mucosal injury caused by H. pylori infection.
l-Arginine as Bio-Based Curing Agent for Epoxy Resins: Temperature-Dependence of Mechanical Properties
Authors: Rothenhäusler Florian , Ruckdaeschel Holger 
Published: November 2022

The precise characterization of new bio-based thermosets is imperative for the correct assessment of their potential as matrix material in fiber-reinforced polymer composites. Therefore, the mechanical properties of diglycidyl ether of bisphenol a (DGEBA) cured with l-arginine were investigated to determine whether the bio-based thermoset possesses the required mechanical properties for application as a matrix material. The cured thermoset is called Argopox. The mixture of amino acid and epoxy resin was prepared via three-roll milling and cured in the presence of an urea-based accelerator. The tensile, compression, flexural and toughness properties of Argopox were characterized at T=−40 ∘C, 22 ∘C and 80 ∘C to determine the temperature-dependence of the thermoset’s mechanical properties in its service temperature range. The glass transition temperature Tg was analyzed via dynamic mechanical analysis (DMA) and is approximately 119 ∘C. The tensile, compression and flexural strength at 22 ∘C are about 56 MPa, 98 MPa and 85 MPa, respectively. The critical stress intensity factor KIC and fracture energy GIC at 22 ∘C are roughly 1.1 MPam0.5 and 510 Jm−, respectively. Consequently, Argopox possesses mechanical properties that reach performance levels similar to that of materials which are already used as matrix for fiber reinforced composites.
The Potential and Green Chemistry Attributes of Biopesticides for Sustainable Agriculture
Authors: Fenibo Emmanuel O. , Ijoma Grace N. , Nurmahomed Weiz , Matambo Tonderayi 
Published: November 2022

Chemotherapy has advanced modern agriculture with costly side effects such as the extinction of beneficial species, resistant pest resurgence, environmental pollution, tainted food consumption, and health implications. Attention is now focused on biopesticides as a solution to the abovementioned disadvantages. Additionally, there is a growing need to understand the range and relative effectiveness of biopesticides in controlling pests and promoting sustainable agriculture. The latter is the major driver of the Sustainable Development Goals (SDGs). In comparison to synthetic pesticides, biopesticides offer nearly similar protection against the most notorious pests, except Albugo candida (oomycetes), Ustilago maydis (fungi), Phytomonas spp. (protozoa), Nacobbus aberrans (nematode), and Cyperus rotundus (weed). This study shows that viruses are more vulnerable to essential oils, nematodes and weeds to natural enemies, herbivorous insects to biochemical insecticides, and plant pathogens to plant-incorporated protectants and microbial pesticides. This work also demonstrates that it is preferable to use plant-derived biopesticides in a field concurrently. Incorporating these findings into large-scale farming via the integrated pest management method would improve the outcome of sustainable agriculture (SA), which connects 11 of the 17 SDGs. Despite their proven efficacy and sustainable attributes, biopesticides have some deficiencies, such as slow action and a short shelf life span, which can be improved by omics, RNA interference, and nano-based technologies. This field of technologies provides relevant prospects for improving existing biopesticides and discovering and developing new bio-controlling agents (BCA).