bluuebunny/crossref_metadata_2025_split huggingface dataset:
U-Shaped Association Between Blood Pressure and Mortality Risk in ICU Patients With Atrial Fibrillation: The MIMIC-III Database
Authors: Shao Ying , Hu Jinzhu 
Published: June 2022

BackgroundExisting evidence on the association between blood pressure (BP) and mortality risk in intensive care unit (ICU) patients with atrial fibrillation (AF) is scarce.AimThis study aimed to assess the associations between blood pressure (BP) and risks of in-hospital and all-cause mortality in ICU patients with AF.MethodsA total of 2,345 records of patients with AF whose BP was monitored after admission to the ICU were obtained from the MIMIC-III database. Incidences were calculated for endpoints (hospital mortality, 7-day mortality, 30-day mortality, and 1-year mortality). We performed smooth curve and logistic regression analyses to evaluate the association between BP and the risk of each endpoint.ResultsSmooth curve regression showed that systolic blood pressure (SBP), mean arterial pressure (MBP), and diastolic blood pressure (DBP) followed U-shaped curves with respect to endpoints (hospital mortality, 7-day mortality, 30-day mortality, and 1-year mortality). The incidence of these endpoints was lowest at 110/70/55 mm Hg. There was an increased risk of 1-year mortality observed with BP &gt; 110/70/55 mm Hg (SBP, odds ratio [OR] = 1.008, 95% CI 1.001–1.015, p = 0.0022; MBP, OR = 1.010, 95% CI 1.005–1.016, p &lt; 0.001) after adjusting for age, sex, and medical history. In contrast, an inverse association between BP and the risk of 1-year mortality was observed with BP ≤ 110/70/55 mm Hg (SBP, OR = 0.981, 95% CI 0.974–0.988, p &lt; 0.001; MBP OR = 0.959, 95% CI 0.939–0.979, p &lt; 0.001; and DBP, OR = 0.970, 95% CI 0.957–0.983, p &lt; 0.001).ConclusionsWe observed a U-shaped association between BP and in-hospital/all-cause mortality in ICU patients with AF. However, the underlying causes need to be investigated.
Relationship Between Length and Curvature of Ascending Aorta and Type a Dissection
Authors: Sun Lianjie , Li Xiao , Wang Guoqing , Sun Jianchao , Zhang Xiaoming , Chi Honghui , Cao Huihui , Ma Wanteng , Yan Zhisheng , Liu Gaoli 
Published: June 2022

BackgroundType A aortic dissection (TAAD) has a rapid onset and high mortality. Currently, aortic diameter is the major criterion for evaluating the risk of TAAD. We attempted to find other aortic morphological indicators to further analyze their relationships with the risk of type A dissection.MethodsWe included the imaging and clinical data of 112 patients. The patients were divided into three groups, of which Group 1 had 49 patients with normal aortic diameter, Group 2 had 22 patients with ascending aortic aneurysm, and Group 3 had 41 patients with TAAD. We used AW Server software, version 3.2, to measure aorta-related morphological indicators.ResultsFirst, in Group 1, the univariate analysis results showed that ascending aortic diameter was correlated with patient age (r2 = 0.35) and ascending aortic length (AAL) (r2 = 0.43). AAL was correlated with age (r2 = 0.12) and height (r2 = 0.11). Further analysis of the aortic morphological indicators among the three groups found that the median aortic diameter was 36.20 mm in Group 1 (Q1–Q3: 33.40–37.70 mm), 42.5 mm in Group 2 (Q1–Q3: 41.52–44.17 mm) and 48.6 mm in Group 3 (Q1–Q3: 42.4–55.3 mm). There was no significant difference between Groups 2 and 3 (P &gt; 0.05). Group 3 had the longest AAL (median: 109.4 mm, Q1–Q3: 118.3–105.3 mm), followed by Group 2 (median: 91.0 mm, Q1–Q3: 95.97–84.12 mm) and Group 1 (81.20 mm, Q1–Q3: 76.90–86.20 mm), and there were statistically significant differences among the three groups (P &lt; 0.05). The Aortic Bending Index (ABI) was 14.95 mm/cm in Group 3 (Q1–Q3: 14.42–15.78 mm/cm), 13.80 mm/cm in Group 2 (Q1–Q3: 13.42–14.42 mm/cm), and 13.29 mm/cm in Group 1 (Q1–Q3: 12.71–13.78 mm/cm), and the difference was statistically significant in comparisons between any two groups (P &lt; 0.05). Regression analysis showed that aortic diameter + AAL + ABI differentiated Group 2 and Group 3 with statistical significance (area under the curve (AUC) = 0.834), which was better than aortic diameter alone (AUC = 0.657; P &lt; 0.05).ConclusionsWe introduced the new concept of ABI, which has certain clinical significance in distinguishing patients with aortic dissection and aneurysm. Perhaps the ascending aortic diameter combined with AAL and ABI could be helpful in predicting the occurrence of TAAD.
The Impact of the Three Gorges Reservoir on Water Exchange Between the Yangtze River and Poyang Lake
Authors: Zhang Peipei , Mao Jingqiao , Tian Mingming , Dai Lingquan , Hu Tengfei 
Published: June 2022

The Three Gorges Reservoir (TGR) operation has profoundly altered the hydrological regimes and ecosystem in the middle and lower Yangtze River basin. Its impacts on the river flow regime, sedimentation, lake level decline, and biodiversity have been extensively studied. However, the quantitative influence of the TGR on the downstream water exchange between the Yangtze River and Poyang Lake is lacking attention. In this study, we developed a machine learning model to investigate the river–lake water exchange variations under the TGR operation in typical hydrological years, compared with the natural scenario (i.e., no TGR). The results show that the machine learning model could provide a fast and accurate approach to identify the long-distance impact of reservoirs. The operation of the TGR has significant effects on the water exchange between the Yangtze River and Poyang Lake in the impounding period, with a 10,000 m³/s decrease in reservoir discharge approximately causing a 4,000 m³/s decrease in river–lake water exchange in the dry year and a decrease of 6,000 m³/s and 8,000 m³/s in reservoir discharge causing an increase of 4,000 m³/s and 6,000 m³/s in the normal year and the wet year, respectively. The TGR effect varies with different hydrological conditions of the river and lake, showing longer time range (from May to October) and greater degree (1.5 times the change rate in other years) in the wet year. The TGR operation is beneficial to the water maintenance of the lake in the dry year and flood control in the lake area in the wet year. This study provides a constructive approach and valuable information for decision making in water resource management and ecosystem protection in large river–lake systems.
Evidence of Hydrocarbon Generation and Overpressure Development in an Unconventional Reservoir Using Fluid Inclusion and Stable Isotope Analysis From the Early Triassic, Western Canadian Sedimentary Basin
Authors: Kingston Andrew , Ardakani Omid H. , Watt Elizabeth , Samson Iain M. 
Published: June 2022

Deep burial of sedimentary basins results in the development of complex diagenetic environments influenced by pressure, temperature, and metasomatic chemical processes. Fracture systems resulting from deep tectonic-related burial can provide archives of physio-chemical characteristics during burial helping unravel diagenetic events such as hydrocarbon migration and paleobarometry. The Early Triassic Montney Formation in the Western Canadian Sedimentary Basin is a highly productive unconventional hydrocarbon reservoir that has undergone multiple phases of tectonic-related burial and uplift resulting in the formation of a series of calcite-filled fracture systems. These fracture systems occur as vertical to sub-vertical fractures, brecciated zones, and horizontal bedding-plane parallel fractures that are rich in co-occurring, but not co-genetic aqueous and petroleum fluid inclusion assemblages. Fluid inclusion microthermometry, Raman spectroscopy, and stable isotope analysis of these fracture systems and host rock reveals paleobarometric and temperature conditions during fracture formation. Vertical fractures formed at temperatures exceeding 142°C during peak burial associated with the Laramide orogeny ∼50 Ma. Similarities in modeled oxygen isotope values of calcite parent fluids and pore water implicate locally sourced carbonate in fracture calcite. Therefore, low permeability and closed system-like conditions were prevalent throughout initial fracture formation and cementation. Petrographic analysis of brecciated and horizontal fractures show evidence of hydrocarbon generation and migration into fracture-filling calcite. Modeling of petroleum inclusion paleobarometry indicates entrapment pressures approaching or even exceeding lithostatic pressure consistent with the development of overpressure associated with the thermal maturation of organic matter following peak burial. Combined use of aqueous and petroleum fluid inclusions in this deeply buried sedimentary system offers a powerful tool for better understanding diagenetic fluid flow, the timing of hydrocarbon migration/maturation, and helps constrain the pressure-temperature history important for characterizing economically important geologic formations.
Association of Vitamin D Anabolism-Related Gene Polymorphisms and Susceptibility to Uterine Leiomyomas
Authors: Xie Shangdan , Jiang Mengying , Liu Hejing , Xue Fang , Chen Xin , Zhu Xueqiong 
Published: June 2022

Background: Uterine leiomyomas (ULs) is the most common gynecological benign tumor in women. Our previous study showed that the phenomenon of vitamin D deficiency existed in patients with ULs. However, the association of vitamin D anabolism-related gene polymorphisms and susceptibility to ULs was unclear.Methods: Vitamin D anabolism-related gene polymorphisms in 110 patients with ULs and 110 healthy controls were detected by sequencing and the differences of the 92 SNPs were analyzed in the two groups via chi-square test. To verify the association between the significantly different SNPs and the risk of ULs, the SNPs were genotyped in another 340 patients and 340 healthy controls. Additionally, an unconditional logistic regression model was conducted to calculate the odds ratio (OR) of ULs occurrence and the 95% confidence interval (CI), adjusting for age and BMI.Findings: In sequencing samples, there were differences in DHCR7 rs1044482 C &gt; T (p = 0.008) and NADSYN1 rs2276360 G &gt; C (p = 0.025) between patients with ULs and healthy controls. DHCR7 rs1044482 was related to the susceptibility to ULs in validation samples (heterogeneous: adjusted OR = 1.967, p = 0.002; homogenous: adjusted OR = 2.494, p = 0.002; additive: adjusted OR = 1.485, p &lt; 0.041; and dominant: adjusted OR = 2.084, p &lt; 0.001). Stratified analysis further showed that the DHCR7 rs1044482 polymorphisms were associated with ULs risks in women over 40 and with 18.5–25.0 BMI. In contrast to the wild-type CG haplotype vectors, individuals with TC haplotypes had a higher risk of developing ULs.Interpretation: The vitamin D anabolism-related gene DHCR7 rs1044482 C &gt; T polymorphism was a risk factor of ULs, especially in patients over 40 with 18.5–25.0 BMI, while the relationship between NADSYN1 rs2276360 and ULs risk was not clear.
A Necroptosis-Related lncRNA Signature Predicts Prognosis and Indicates the Immune Microenvironment in Soft Tissue Sarcomas
Authors: Liu Binfeng , Liu Zhongyue , Feng Chengyao , Tu Chao 
Published: June 2022

Background: The necroptosis and long noncoding RNA (lncRNA) are critical in the occurrence and development of malignancy, while the association between the necroptosis-related lncRNAs (NRlncRNAs) and soft tissue sarcoma (STS) remains controversial. Therefore, the present study aims to construct a novel signature based on NRlncRNAs to predict the prognosis of STS patients and investigate its possible role.Methods: The transcriptome data and clinical characteristics were extracted from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression database (GTEx). A novel NRlncRNA signature was established and verified by the COX regression analysis and least absolute shrinkage and selection operator (LASSO) regression analysis. Subsequently, the K-M survival analysis, ROC, univariate, multivariate Cox regression analysis, and nomogram were used to evaluate the predictive value of the signature. Also, a variety of bioinformatic analysis algorithms explored the differences between the potential mechanism, tumor immune status, and drug sensitivity in the two-risk group. Finally, the RT-qPCR was performed to evaluate the expression of signature NRlncRNAs.Results: A novel signature consisting of seven NRlncRNAs was successfully established and verified with stable prediction performance and general applicability for STS. Next, the GSEA showed that the patients in the high-risk group were mainly enriched with tumor-related pathways, while the low-risk patients were significantly involved in immune-related pathways. In parallel, we found that the STS patients in the low-risk group had a better immune status than that in the high-risk group. Additionally, there were significant differences in the sensitivity to anti-tumor agents between the two groups. Finally, the RT-qPCR results indicated that these signature NRlncRNAs were abnormally expressed in STS.Conclusion: To the best of our knowledge, it is the first study to construct an NRlncRNA signature for STS. More importantly, the novel signature displays stable value and translational potential for predicting prognosis, tumor immunogenicity, and therapeutic response in STS.
Blood-Cell-Based Inflammatory Markers as a Useful Tool for Early Diagnosis in Colorectal Cancer
Authors: Hernandez-Ainsa Maria , Velamazan Raul , Lanas Angel , Carrera-Lasfuentes Patricia , Piazuelo Elena 
Published: June 2022

BackgroundSystemic inflammation seems to be involved in the pathogenetic pathways of colorectal cancer (CRC). Analytical markers that reflect the inflammatory status, such as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) or systemic immune-inflammation index (SII), have been proposed as tools for the prognosis of CRC. Nevertheless, their use for diagnosis has been scarcely investigated.AimsTo analyze the ability of these markers and of a new marker combining SII and hemoglobin concentration, named NP/LHb = [neutrophils x platelets]/[lymphocytes x hemoglobin], as tools for CRC diagnosis. Furthermore, we studied their association with CRC-related variables.MethodsCase-control study including 214 CRC patients and 214 controls without CRC, matched by age (±5 years) and sex. We collected demographic, CRC-related and laboratory variables to calculate NLR, PLR, SII, and NP/LHb. In the case group, the laboratory variables were collected at two different period times, 6 months (IQR 4–8) before the CRC diagnosis and at the time of the diagnosis. ROC analysis was performed to evaluate the discriminatory accuracy of each index and we calculated Se, Sp, PPV, NPV, and OR to identify the diagnostic performance of each positive marker.ResultsNP/LHb showed high Sp (92.06%) and PPV (87.50%) to diagnose patients with CRC. This index exhibited an OR of 14.52 (8.26–25.52) and the best area under the curve (AUC: 0.78) for a positive CRC diagnosis. We found significant differences in all indices according to the presence of CRC, observing the highest values in CRC patients at time of diagnosis, in comparison with the analysis performed in the previous months to diagnosis or with control patients. There were significant differences in all ratios according to TNM stages (p &lt; 0.05). PLR, SII and NP/LHb (but not NLR) showed significant differences according to tumor location (p &lt; 0.05). Right-sided colon cancers presented the highest values, in comparison with left-sided and rectal cancers.ConclusionsSystemic inflammatory cell ratios (especially NP/LHb) change over time with the development of CRC, so they could be useful in its early diagnosis. We suggest that they could be routinely measured in patients with suspicion of CRC, to identify those ones with a higher risk of cancer, considering the high positive predictive value they have shown in our study.
Giant Cell Arteritis Presenting With Ocular Symptoms: Clinical Characteristics and Multimodal Imaging in a Chinese Case Series
Authors: Chen Qian , Chen Weimin , Feng Chaoyi , Gong Deshan , Zhang Jiong , Bi Yingwen , Sun Ping , Sun Xinghuai , Tian Guohong 
Published: June 2022

PurposeTo evaluate demographic and clinical characteristics of a Chinese population with giant cell arteritis using multimodal imaging focusing on ophthalmic examinations.DesignRetrospective observational case series.Materials and MethodsIn the neuro-ophthalmology division of the Eye, Ear, Nose, and Throat Hospital, Shanghai, we evaluated the demographic and clinical characteristics of patients diagnosed with giant cell arteritis between January 2016 and June 2021. Results of routine ophthalmic examinations including fundus examination, optical coherence tomography, color duplex ultrasonography of ocular and superficial temporal arteries, orbital magnetic resonance imaging, and superficial temporal artery biopsy were evaluated.ResultsA total of 15 patients (22 eyes; ten male and five female) were evaluated with a mean age of 77.0 ± 8.5 years. Among them, seven had bilateral involvement that occurred simultaneously or sequentially. Twelve patients presented with arteritic anterior ischemic optic neuropathy, two with arteritic anterior ischemic optic neuropathy combined with cilioretinal artery occlusion, and one with cotton-wool spots. In acute stages of optic neuropathy and retinopathy, optical coherence tomography revealed optic disc edema, thickening of the inner retinal nerve fiber layer and ganglion cell layer, and loss of layer structure. In late stages, optical coherence tomography revealed diffuse atrophy of the inner retina. The “halo” sign was observed in 12 patients in the superficial temporal artery ultrasound, and seven out of eight patients who underwent biopsy demonstrated classic giant cell arteritis pathological changes. Most patients having poor visual acuity but ability to perceive light; 10/22 eyes had permanent vision loss.ConclusionAlthough rare in Asians, giant cell arteritis may be underdiagnosed among elderly Chinese patients presenting with anterior ischemic optic neuropathy. Non-invasive superficial temporal artery ultrasound detecting inflammatory thickening of the intima as the “halo” sign combined with routine elevated erythrocyte sedimentation rate and C-reactive protein may be helpful in diagnosing patients with a high probability of having giant cell arteritis.
Predicting Preeclampsia Pregnancy Termination Time Using sFlt-1
Authors: Tanaka Hiroaki , Tanaka Kayo , Takakura Sho , Enomoto Naosuke , Ikeda Tomoaki 
Published: June 2022

BackgroundThe aim of this study was to determine the usefulness of placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) in predicting the time for pregnancy termination in pregnant women with known preeclampsia (PE) onset.MethodsForty-four pregnant women diagnosed with PE (22 weeks 0 days to 33 weeks 6 days gestation) were included in this study. The levels of sFlt-1 and PlGF, and the sFlt-1/PlGF ratio were compared between the women that delivered in &lt;24 h (T group) and those that delivered in more than 24 h (P group), and between women that delivered in &lt;1 week (T group) and those that delivered in more than 1 week (P group). Cutoff values were calculated for the three markers that were the most significantly correlated with predicting pregnancy termination at &lt;24 h and &lt;1 week.ResultsAmong sFlt-1, PlGF, and sFlt-1/PlGF, sFlt-1 was the most significantly associated with the timing of pregnancy termination. sFlt-1 cutoff values of 8682.1 pg/ml (AUC 0.71; 95%Cl, 0.5191–0.9052) and 7,394.5 pg/ml (AUC 0.78; 0.78, 95%Cl, 0.6394–0.9206) for delivery in &lt;24 h and delivery within 1 week, respectively, were important predictive values. The positive predictive value for delivery within 24 h was 43.9%, with a sensitivity of 72.3% and specificity of 69.0%, when sFlt−1 was &lt;8,682 pg/ml. A sFlt-1 level of 7,394 pg/ml or greater would result in delivery within 1 week, with a positive predictive value of 67.2%; the sensitivity was 79.0% and specificity was 72.0%.ConclusionThis study showed that sFlt-1 may be effective in predicting the timing of pregnancy termination. However, the number of cases was small and, thus, the results were not definitive. This finding should be researched further in order to predict the optimal timing of pregnancy termination in PE to reduce severe maternal complications.
Relationship Between Invasive Fungal Infection and Hypostatic Pneumonia: A Prospective Cohort Study
Authors: Liu Lin , Liu Chang , Cai Jianrong , Chen Jiayun , Chen Jie , Fu Yuanyuan , Yi Kexin , Wang Hui , Li Xue 
Published: June 2022

BackgroundThe short-term mortality of hypostatic pneumonia (HP) is very high, and the treatment outcome is poor. The clinical diagnosis and treatment are primarily focused on bacterial and viral infection, ignoring the role of fungal infection at present. This study aims to validate the relationship between Invasive Fungal Infections (IFI) and HP.MethodsIn the cross-sectional study, a total of 11,371 participants have been enrolled. In the prospective cohort study, 4,441 individuals have been included at baseline and followed up from 2015 to 2019 with a total person years of 8,484.65. The standard procedures were used to assess questionnaire investigations, laboratory testing, and anthropometric indicators. For data analysis, logistic regression, restricted cubic spline, log-rank regression, Cox regression, and linear mixed effects model were applied to assess the relationship between IFI and HP risk longitudinally.ResultsIn the cross-sectional study, elevated β-D-Glucan (BDG) concentrations are associated with a higher risk of HP prevalence in the total population, men, and women (ORT3 vs.T1 [95% CIs]: 2.12 [1.55, 2.91]; 2.01 [1.35, 2.99]; 2.34 [1.39, 3.94]), which were verified by a dose–effect relationship in the restricted cubic spline model. In the cohort study, Cox and Log-rank regression showed that the elevated BDG concentrations are associated with a significantly higher risk of HP incidence than participants with lower BDG concentrations (HRT3 vs.T1 [95% CIs]: 2.72 [1.36, 5.43], pLog–rank = 0.0086). During 5 years, the globulin (GLB) and C-reactive protein (CRP) were always on the top in the highest category of BDG concentrations. Between low and high BDG concentration, the total trend of GLB concentration was falling and the total trend of CRP concentration was rising with the increase of years (all the p-values &lt; 0.0001).ConclusionIn this study, IFI is associated with a higher risk of HP, with time sequence and related mechanisms requiring further investigation in the future.