bluuebunny/crossref_metadata_2025_split huggingface dataset:
A miniaturized CRLH based SIW leaky‐wave antenna for continuous backward‐to‐forward fast beam scanning with low side lobe levels
Authors: Agarwal Ruchi , Yadava Ram Lal , Das Sushrut 
Published: September 2022

AbstractIn this study, a substrate‐integrated waveguide (SIW)‐based miniaturized leaky‐wave antenna (LWA) with fast beam scanning is proposed. The proposed LWA exhibits composite right/left‐handed (CRLH) property and its unit cell consist of an inverted Z‐shaped slot etched on the top layer of SIW. By sweeping frequency from 9.4 to 11.4 GHz, the proposed CRLH LWA can steer the frequency beam continuously from −40° to 51°, which shows fast beam scanning within the impedance bandwidth (2 GHz) of LWA. The good leakage constant contributes to the miniaturization of the LWA with electrical dimensions of 3.38λ0 × 0.34λ0 mm2. The antenna attains a peak gain of 12.5 dBi with maximum radiation efficiency of 92%. The antenna attains low sidelobe levels below 12 dB; the low sidelobe levels in the LWA are obtained by creating symmetricity in the unit cell around the centerline. The designed LWA is a viable contender for X‐band beam scanning applications.
Laparoscopic posterior vaginal plication plus sacral colpopexy for severe posterior vaginal prolapse: A randomized clinical trial
Authors: Morciano Andrea , Ercoli Alfredo , Caliandro Dario , Campagna Giuseppe , Panico Giovanni , Giaquinto Alessia , Zullo Marzio Angelo , Tinelli Andrea , Scambia Giovanni , Marzo Giuseppe , Cervigni Mauro 
Published: September 2022

AbstractAimA randomized clinical trial proposing a new laparoscopic prosthetic and fascial approach to severe posterior vaginal prolapse. The primary endpoint was to evaluate the objective and subjective outcomes of our laparoscopic posterior plication (LPP) combined to “two‐mesh” sacral colpopexy (laparoscopic sacral colpopexy [LSC]) in severe posterior vaginal prolapse, with a 1‐year follow‐up. The secondary endpoint was to evaluate the safety of this surgical procedure.MethodsThis is single‐center prospective randomized double‐blinded clinical trial. A total of 130 consecutive patients with anterior and/or apical pelvic organ prolapse (POP) (POP‐Q stage ≥II) and severe posterior vaginal prolapse (posterior POP‐Q stage ≥III) were prospectively assessed for inclusion into the study from November 2018 to January 2020. Patients underwent “two‐meshes” LSC and were randomized in Group A (LSC plus LPP) and Group A (LSC alone). Of the 130 included subjects, 8 were excluded, not meeting inclusion criteria. Cure rate was evaluated objectively, using POP‐Q study, and subjectively using PGI‐I, POPDI‐6, and FSDS questionnaires. Complications were assessed intra‐, peri‐, and postoperatively. Twelve‐month follow‐ups were analyzed for the study.ResultsWe found in LSC plus LPP Group a significant improvement of Ap and genital hiatus POP‐Q points. Our subjective study showed, at 12 months, a statistical difference in PGI‐I successful outcomes rate in favor of LPP. Also the FSDS resulted significantly much more improved in Group A. We observed no statistical differences in terms of postoperative complications.ConclusionsOur LPP approach to LSC could be considered an effective and safe technique to POP patients with severe posterior prolapse.
Predictors of pulmonary involvement in children with COVID‐19: How strongly associated is viral load?
Authors: Yakut Nurhayat , Yakut Kahraman , Sarihan Zeynep , Kabasakal Irem , Aydin Murat , Karabulut Nuran 
Published: September 2022

AbstractThe purpose of this study was to identify risk factors for pulmonary involvement by examining the demographic, clinical, and laboratory characteristics of children with COVID‐19. We performed a retrospective single‐center study of COVID‐19 in children treated at a tertiary care hospital in Turkey from December 2020 to June 2021. During the course of the study, 126 patients were evaluated, of whom 70/126 were male. The patients' ages ranged from 1 to 216 (mean, 4.73 ± 81.11) months. Fever (65.9%), cough (52.4%), and shortness of breath (18.3%) were the most common symptoms of COVID‐19. Ten patients required noninvasive mechanical ventilation. Sixty‐nine patients (54.8%) had pneumonia. Longer duration of fever, hospitalization, and the presence of cough were significantly associated with pulmonary involvement. Children with pneumonia had significantly higher levels of C‐reactive protein (CRP), procalcitonin, erythrocyte sedimentation rate (ESR), and viral load, and significantly lower counts of lymphocytes and thrombocytes. The cutoff viral load, CRP, and procalcitonin values for predicting pulmonary involvement were 26.5 cycle threshold (Ct; 95% confidence interval [CI], 0.54–0.74; sensitivity, 0.65; specificity, 0.56; area under curve [AUC]: 0.647, p = 0.005), 7.85 mg/L (95% CI, 0.56–0.75; sensitivity, 0.66; specificity, 0.64; AUC = 0.656; p = 0.003) and 0.105 ng/ml (95% CI, 0.52–0.72; sensitivity, 0.55; specificity, 0.58; AUC = 0.626; p = 0.02), respectively. High CRP, procalcitonin levels, ESR, and viral load, and low lymphocyte and thrombocyte counts can predict pulmonary involvement in children with COVID‐19, so better management may be provided for good prognosis.
Quercetin alleviates ethanol‐induced hepatic steatosis in L02 cells by activating TFEB translocation to compensate for inadequate autophagy
Authors: Zhao Xingtao , Xue Xinyan , Wang Jing , Dai Shu , Peng Cheng , Li Yunxia 
Published: September 2022

AbstractThis study aimed to investigate the therapeutic effect of quercetin on ethanol‐induced hepatic steatosis in L02 cells and elucidate the potential mechanism. In brief, L02 cells were pretreated with or without ethanol (3%) for 24 h, then treated quercetin (80, 40, 20 μM) for 24 h. The transfection procedure was performed with transcription factor EB (TFEB) small interfering RNA (siRNA TFEB) for 24 h. Our results showed that quercetin autophagic flux in the L02 cells, via upregulating of microtubule associated protein light chain 3B (LC3‐II) and lysosome‐associated membrane protein 1 (LAMP1), then downregulating of protein sequestosome 1 (SQSTM1/p62). Mechanistically, quercetin activated TFEB nuclear translocation, contributing to lysosomal biogenesis and autophagic activation. Accordingly, the genetic inhibition of TFEB‐dependent autophagy decreased ethanol‐induced fat accumulation in L02 cells via regulating fatty acid β oxidation and lipid synthesis. Subsequently, quercetin‐induced TFEB‐dependent autophagic activation was also linked to inhibit oxidative stress via suppressing reactive oxygen species (ROS), enhancing activities of antioxidant enzymes, and promoting nuclear transfer of the nuclear factor E2‐related factor 2 (Nrf2) translocation. Thus, we uncovered a novel protective mechanism against ethanol‐induced hepatic steatosis and oxidative stress through TFEB‐mediated lysosomal biogenesis and discovered insufficient autophagy as a novel previously unappreciated autophagic flux.
Insulin‐like peptide 3 in domestic animals with normal and abnormal reproductive functions, in comparison to rodents and humans
Authors: Kawate Noritoshi 
Published: September 2022

AbstractBackgroundInsulin‐like peptide 3 (INSL3) is a circulating hormone secreted from only testis and ovaries in mammals. Findings on INSL3 have been gathered from subjects with normal and abnormal reproductive statuses, especially rodents and humans. However, little to no review articles focusing on INSL3 in domestic animals exist.MethodsThe author reviewed the past and recent literature regarding the structure, expression, roles of INSL3 in the reproductive organs, and its circulation under normal and aberrant reproductive conditions in domestic animals in comparison with rodents and humans.Main findingsAs with humans and rodents, blood INSL3 concentrations rise around puberty in normal male domestic animals and are associated with testicular size. INSL3 levels are acutely upregulated by luteinizing hormone (LH), and the increase is smaller than that of testosterone in male ruminants, whereas the acute regulation of INSL3 by LH does not occur in human men. Dogs with cryptorchidism and bulls with abnormal semen have lowered INSL3 levels.ConclusionThe findings regarding INSL3 secretions in male domestic animals with normal and aberrant reproductive functions illustrate similar or dissimilar points to humans and rodents. Data on blood INSL3 levels in normal and abnormal female domestic species are still limited and require further investigation.
Understanding the socio‐economic impacts of climate change on riparian communities in Bangladesh
Authors: Leal Filho Walter , Wolf Franziska , Abubakar Ismaila Rimi , Al‐Amin Abul Quasem , Roy Sajal , Malakar Krishna , Alam G. M. Monirul , Sarker Muhammad Nazirul Islam 
Published: September 2022

AbstractRiparian communities in developing countries such as Bangladesh, whose livelihoods depend especially on fisheries and other subsistence activities, are under considerable pressure due to climate change. Therefore, there is a need to better understand how the dynamics of riparian communities are influenced by climate change and how its impacts can be assessed. Using Bangladesh as an example, this paper describes the various climate stressors affecting riparian communities and their socio‐economic impacts, and it outlines some measures needed to increase their resilience to a changing climate. The results show that riparian communities are not only quite vulnerable to the impacts of climate change but also have a rather low level of resilience. This challenge can, at least in part, be attributed to their fragile living conditions, which intensify the socio‐economic impacts of extreme events. One lesson from the paper is that handling climate‐induced risks in riparian communities requires implementing strategic measures to improve local climate and livelihood resilience, such as effective public health infrastructure and a resilient built environment. Win‐win scenarios comprise strategies that offer multiple benefits including better water storage, flood control, and improved riparian habitats.
Potential of Dual Drug Delivery Systems: MOF as Hybrid Nanocarrier for Dual Drug Delivery in Cancer Treatment
Authors: Singh Ragini , Prasad Amrita , Kumar Binayak , Kumari Soni , Sahu Ram Krishna , Hedau Suresh T. 
Published: September 2022

AbstractSynergistic action of combination therapy can be enhanced by appropriate selection of drugs combination that might reduce the likelihood acquired resistance to chemotherapy in cancer. Nano based formulations offer a parallel opportunity to design advance combination drug delivery systems with specific internal and external stimulus. In recent years, there has been a lot of interest in the study of metal–organic frameworks (MOFs) for biomedical applications. Because of their extraordinary chemical properties such as tunable porous structure with high surface area MOFs are an infancy material used in drug delivery systems as a nacarrier. MOFs are regarded as a promising class of nanocarriers for drug delivery owing to well‐defined structure, ultrahigh surface area and porosity, tunable pore size, and easy chemical functionalization. Herein we summarize the most recent progress in stimuli‐based dual drug‐delivery systems including inorganic and organic nanocarriers. Moreover, we have highlighted the specific stimuli responsive nano‐MOFs as dual drug delivery systems, which offer a fresh perspective for development of hybrid nanocarrier to overcome the drawbacks of pure organic and inorganic carriers, such as toxicity, lower payload capacity and burst effect.
A Fluorescent Polymer Coated Sensor Chip for Mercury Ion (Hg2+) Determination in Lake Water
Authors: Muhammad Imran , Muhammad Turghun , Hoji Amina , Imerhasan Mukhtar , Adnan  
Published: September 2022

AbstractNovel dansyl chloride‐based fluorescent polymer‐coated chips (PCFCs) were designed and developed via polymerization of 2‐(5‐(dimethylamino) naphthalen‐1‐ylsulfonyloxy)ethyl methacrylate (DNS‐EMA) on the surface of a 3‐(trimethoxysilyl)propyl methacrylate (MPS) modified glass slide with a supporting membrane. The chemical linkage of DNS‐EMA on PCFC surface was verified by 1H‐NMR, IR, and fluorescence measurements. Particularly, the optimized fluorescent polymer‐coated chip (PCFC6) in 1/1 (v/v) acetonitrile /water exhibited higher sensitivity toward Hg2+ than the other tested metal ions at concentrations ranging from 1.66 μmol/L to 50.6 μmol/L with R2=0.9923. Interestingly, PCFC6 is water‐compatible, photostable and exhibits good selectivity to Hg2+ even at low concentrations compared to other representative metal cations with 89.2‐109.9 % recoveries.
Effect of NaY Zeolite at Different Calcination Temperatures on the Activity in Hydroformylation of Formaldehyde
Authors: Guo Xiaxin , Qiao Luyang , Zong Shanshan , Ye Runping , He Yuntao , Cheng Jiankai , Cao Xinyi , Zhou Zhangfeng , Yao Yuangen 
Published: September 2022

AbstractThe NaY zeolites were prepared by hydrothermal synthesis method. The influence of NaY zeolite calcined at different temperatures as carriers for Rh/NaY catalysts on the hydroformylation of formaldehyde was investigated. The physical and chemical properties of Rh/NaY catalysts and their performance were characterized in details. When the zeolites were calcined at 400–700 °C, the crystal structure and morphology were kept unchanged within this range of calcination temperature. However, the surface crystallinity and surface area were reduced with increasing the temperature due to the partially collapsed of its framework, and thus reducing the confine of cages structure to rhodium species promote its participation in the coordination reaction. The reduction in the amount of surface Lewis acid can reduce the electronegativity of the carrier and change the electronic state of the surface rhodium species, which would weaken the hindrance to anionic speciation and promote CO insertion, which facilitates the hydroformylation of formaldehyde.
Designing of Thiazolidinones for COVID‐19 and its Allied Diseases: An In silico Evaluation
Authors: Raza Muhammad Asam , Farwa Umme , Ain Nida Qurat Ul , Ishaque Fatima , Yaseen Muhammad , Naveed Muhammad , Shabbir Muhammad Aqib 
Published: September 2022

AbstractIn silico studies in terms of density functional theory (DFT), molecular docking, and ADMET (absorption, distribution, metabolism, excretion and toxicity) were performed for 55 thiazolidinones compounds derived from different amines and aldehydes. DFT is a computational quantum mechanical modeling method used to predict the various properties of the compounds. Different parameters such as Electronegativity (x), Chemical Hardness (ŋ), Chemical Potential (μ), Ionization potential (IP), and Electron Affinity (EA), etc. were calculated by Koopmans theorem. The compounds were docked with Molecular Operating Environment (MOE) software using already reported PDB files of BChE, AChE, and α‐glucosidase. To analyze the Spike Glycoprotein of SARS‐Cov‐2 and heterocyclic compounds, molecular interactions study was carried out between Spike Glycoprotein of SARS‐Cov‐2 (6VXX) and 55 synthetic heterocyclic compounds. It was performed by the utilization of PyRx Virtual Screening Tool and AutoDock Vina based virtual environment was used in PyRx. Maximum binding affinity was observed with compound A7 which was −8.7 kcal/mol and then with A5 which was −8.5 respectively. In the case of the AChE enzyme, B5 has a maximum docking score of −12.9027 kcal/mol while C7 depicted the maximum score for the BChE enzyme with a value of −8.6971 kcal/mol. The docking studies revealed that C6 compound has maximum binding capacity toward glucosidase (−14.8735 kcal/mol). ADMET properties of under consideration compounds were determined by Swiss online‐based software which concluded that these molecules have a drug‐like properties and having no violation.
High‐performance ORR Catalyst of N‐doping Carbon‐coated Cobalt Nanoparticles Synthesized by DC Arc Plasma
Authors: Li Shaopeng , Miao Wenfang , Lv Enmin , Cao Xingru , Li Xiyang , Zhang Xuefeng , Yu Hongtao , Dong Xinglong 
Published: September 2022

AbstractIt is necessary to develop the oxygen reduction reaction (ORR) catalysts with aid to promote sluggish electrochemical kinetics in some energy conversion systems, e. g. fuel cells or metal‐air cells. Cobalt‐nitrogen‐carbon catalysts get a lot of attention owing to their excellent ORR performance, durability and lower cost. In this study, the physical vapor condensation route of DC arc plasma was developed to prepare the carbon‐coated cobalt nanoparticles (Co@C NPs) as a prime precursor, which was then suffered from a N‐doping process to harvest the Co@C(N) NPs catalyst materials. The synthesized Co@C(N) NPs exhibit excellent ORR catalytic performances with overt merits, such as lower cost, easy preparation, high‐yield, with respect to the precious metal catalysts. It is indicated that the Co@C(N) catalysts show a higher onset potential (E onset) of 0.99 V (vs. RHE), the limiting current density (J m) of 4.99 mA cm−2, and the excellent durability with only 10 mV of negative shift generated in the half wave potential (E1/2) after 5000 cycles. Synergistic effect between the Co core of Co@C(N) nanoparticles and the active N‐containing sites in carbon layers is responsible for the enhanced catalytic performance, meanwhile the unique core‐shell nanostructure can also effectively protect the catalyst from deterioration in work. The N‐doping carbon‐coated Co@C(N) nanoparticles synthesized by DC arc plasma technique becomes a new strategy for development of non‐noble metal electrocatalysts.
MWCNT Buckypaper as Electrochemical Sensing Platform: A Rapid Detection Technology for Phthalic Acid Esters in Solutions*
Authors: Abeysinghe Hansini , Wickramasinghe Gimhani , Perera Susira , Etampawala Thusitha 
Published: September 2022

AbstractPhthalic Acid Esters (PAEs) are a well‐known ubiquitous environmental pollutant that holds a significant threat to human health. Despite their harmful effects, the constant use of PAEs in producing flexible plastic products has awakened society‘s great concern, especially with their ability to leach, migrate, or evaporate from plastics to the surrounding. Therefore, rapid and easy monitoring of the PAEs presence in different environments is crucial. This study introduces a rapid PAE detection technique that shows potential for overcoming the limitations of already existing PAE detecting methods. This novel PAE sensing platform (buckypaper) is developed using highly conducting Multi‐Walled Carbon Nanotubes (MWCNT). The buckypaper adsorbs PAEs in solutions and decreases its conductivity. This conductivity decrement is detected using the Nyquist and Bode plots obtain from three‐electrode Electrochemical Impedance Spectroscopy (EIS) analysis. This novel method has shown that it has the potential to distinguish DEHP (di‐(2‐ethylhexyl) phthalate), DPHP (di‐(2‐propylheptyl) phthalate), and DnOP (di‐octyl phthalate) from other aromatic molecules such as toluene, xylene, naphthalene, and bisphenol‐A. Moreover, the developed buckypaper is sensitive down to 1000 (v/v) ppm concentrated PAEs in methanol solutions at room temperature, which exhibits the potential of using this platform as an in‐situ and real‐time PAE detecting sensor.
Synthesis and Characterization of Biosurfactants from Non‐edible Feedstocks: Comparative Assessment and Their Applications in Biodiesel
Authors: Rawat Neha , Bhonsle Aman Kumar , Trivedi Jayati , Singh Raj Kumar , Atray Neeraj 
Published: September 2022

AbstractSurfactants are one of the versatile products of the chemical industry owing to their inherent nature to lower the surface and interfacial tension and interface layer stabilization but restricted due to non‐degradability issues and hazardous effects. For combating such problems, bio‐based surfactants (Biosurfactants) could be potential alternative. The biosurfactants are an integral part of life as they have been explored in pharmaceutical sectors, therapeutics, health, food products, health and beauty products, and agriculture, creating sustainable economics and promoting sustainable development goals. Therefore, researchers have been interested in producing, optimizing, and utilizing biosurfactants for various applications. In the present work, biosurfactants were prepared from three different feeds, namely Jatropha carcus, Sapium sebiferum, and used cooking oil (UCO) using sodium bisulfite (NaHSO3) as sulfonating reagent and alumina (Al2O3)as the heterogeneous catalyst to yield 70 %, and comparative assessment was done. The biosurfactant production involved a two‐step process viz. biodiesel production and biosurfactant production thereof. The biodiesel produced in the first step met all the BIS 15607 : 2016 specifications and both products were confirmed through analytical techniques like Fourier transform infrared (FTIR) and Nuclear magnetic resonance (NMR) spectroscopy. Further, the produced biosurfactants were employed to reduce the biodiesel‐glycerol layer separation time, and a significant time reduction in the biodiesel‐glycerol separation was found.
Synthesis of TBAB‐based Deep Eutectic Solvents as the Catalyst in the Coupling Reaction between CO2 and Epoxides under Ambient Temperature
Authors: Wang Zixian , Yan Ting , Guo Li , Wang Qindong , Zhang Ran , Zhan Haijuan , Yi Lan , Chen Jialin , Wu Xiaoqin 
Published: September 2022

AbstractThe development of an efficient, easily prepared, and environmentally friendly catalyst is important for the coupling reaction between CO2 and epoxides. Herein, novel TBAB‐based (tetrabutylammonium bromide, TBAB) deep eutectic solvents (DESs) have been applied in the transformation of CO2 and epoxides into cyclic carbonates with exhibit high activity and selectivity under mild conditions (25 °C, 8 bar CO2), The excellent activity and versatility of the TBAB‐based DESs can be attributed to the hydrogen‐bond interaction between the TBAB and citric acid. Due to hydrogen‐bond interaction between −OH and Br−, the Br− becomes more flexible and facilitates the nucleophilic ring‐opening process. The density functional theory (DFT) method has been used to explore the mechanism governing the CO2 cycloaddition reaction. DFT results imply that intramolecular hydrogen bonding and the flexible nucleophilic Br− anion can significantly accelerate the ring‐opening process. Hence, the ring‐closure reaction may be the rate‐determining step in the CO2 cycloaddition reaction catalyzed by TBAB‐based DESs. Both the experimental and computational results have demonstrated that the synergistic effect between the −OH and Br− in the TBAB‐based DESs play a significant role in the acceleration of the ring‐opening process of the CO2 cycloaddition reaction.
One‐Step Hydrothermal Synthesis of Boric Acid‐Functionalized Carbon Dots and their Applications in Glucose Sensing
Authors: Liu Huiling , Chen Qinqin , Hou Juan , Yang Guang , Feng Wei 
Published: September 2022

AbstractIn this work, a straightforward one‐step hydrothermal method was efficiently applied to prepare boronic acid‐functionalized N‐doped carbon dots (BN‐CDs) using 3‐aminobenzeneboronic acid and ascorbic acid as the starting materials. The BN‐CDs exhibited a size distribution ranging from 1.5 nm to 4.0 nm, demonstrated good fluorescence stability and a high fluorescence quantum yield of 26.03 %. Glucose could accumulate on the surface of BN‐CDs by covalently binding boric acid groups to glucose cis‐glycol, thereby leading to the selective fluorescence quenching performance. A sensitive sensing platform for glucose detection was established in the linear range of 8—940 μmol/L with the detection limit (LOD) of 2.4 μmol/L. Satisfactory results were obtained in three kinds of sample analysis. It is worth mentioning that the incubation time of the proposed sensing platform is much shorter than that of most reported elsewhere. The BN‐CDs based fluorescence detection method demonstrates good feasibility in practical applications.