bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematics of the heavy flavor hadronic molecules
Authors: Chen Kan , Chen Rui , Meng Lu , Wang Bo , Zhu Shi-Lin 
Published: July 2022

AbstractWith a quark level interaction, we give a unified description of the loosely bound molecular systems composed of the heavy flavor hadrons$$({\bar{D}},{\bar{D}}^*)$$(D¯,D¯∗),$$(\Lambda _c, \Sigma _c, \Sigma _c^*)$$(Λc,Σc,Σc∗), and$$(\Xi _c, \Xi _c^\prime ,\Xi _c^*)$$(Ξc,Ξc′,Ξc∗). Using the$$P_c$$Pcstates as inputs to fix the interaction strength of light quark-quark pairs, we reproduce the observed$$P_{cs}$$Pcsand$$T_{cc}^+$$Tcc+states and predict another narrow$$T_{cc}^{\prime +}$$Tcc′+state with quantum numbers$$[D^*D^*]_{J=1}^{I=0}$$[D∗D∗]J=1I=0. If we require a satisfactory description of the$$T_{cc}^+$$Tcc+and$$P_c$$Pcstates simultaneously, our framework prefers the assignments of the$$P_{c}(4440)$$Pc(4440)and$$P_{c}(4457)$$Pc(4457)as the$$[\Sigma _c{\bar{D}}^*]_{J=1/2}^{I=1/2}$$[ΣcD¯∗]J=1/2I=1/2and$$[\Sigma _c{\bar{D}}^*]_{J=3/2}^{I=1/2}$$[ΣcD¯∗]J=3/2I=1/2states, respectively. We propose the isospin criterion to explain naturally why the experimentally observed$$T_{cc}$$Tcc,$$P_c$$Pc, and$$P_{cs}$$Pcsmolecular candidates prefer the lowest isospin numbers. We also predict the loosely bound states for the bottom di-hadrons.
Türkiye’de Çingenelere Yönelik Hak Temelli Politikaların Gelişimi
Authors: ŞAHYAR AKDEMİR Duru 
Published: July 2022

İnsan haklarının korunması konusunda her ne kadar tek tek kişilere görev düşse de bu konuda devlet, sivil toplum örgütleri ve diğer aktörler de sorumluluk sahibidir. Devlet, insan haklarının koruyucusu konumunda olup her türden hakkın özünün gerçekleşmesinde temel bir rol oynamaktadır. Türkiye’de insan haklarına dair politikaların geliştirilmesi ve insan haklarının korunması konusunda düzenlemelerin yapılması 1990’lı yıllarda başlamıştır. Çingeneler özelinde ise bu düzenlemelerin 2000’li yıllarla birlikte hayata geçirilmeye başlandığı ifade edilebilir.
Bu doğrultuda çalışmanın amacı Çingenelere yönelik hak temelli politikaları uluslararası gelişmeleri de dikkate alarak tarihsel çerçevede ele almaktır. Çalışmada Türkiye’de gerçekleştirilen hak temelli politikalar Çingene haklarına etkileri özelinde incelenmiş ve inceleme sonuçlarına dayanarak insan haklarının korunması ve iyileştirilmesi noktasında önerilerde bulunulmuştur.
Development and validation of a horse reference panel for genotype imputation
Authors: Reich Paula , Falker-Gieske Clemens , Pook Torsten , Tetens Jens 
Published: July 2022

AbstractBackgroundGenotype imputation is a cost-effective method to generate sequence-level genotypes for a large number of animals. Its application can improve the power of genomic studies, provided that the accuracy of imputation is sufficiently high. The purpose of this study was to develop an optimal strategy for genotype imputation from genotyping array data to sequence level in German warmblood horses, and to investigate the effect of different factors on the accuracy of imputation. Publicly available whole-genome sequence data from 317 horses of 46 breeds was used to conduct the analyses.ResultsDepending on the size and composition of the reference panel, the accuracy of imputation from medium marker density (60K) to sequence level using the software Beagle 5.1 ranged from 0.64 to 0.70 for horse chromosome 3. Generally, imputation accuracy increased as the size of the reference panel increased, but if genetically distant individuals were included in the panel, the accuracy dropped. Imputation was most precise when using a reference panel of multiple but related breeds and the software Beagle 5.1, which outperformed the other two tested computer programs, Impute 5 and Minimac 4. Genome-wide imputation for this scenario resulted in a mean accuracy of 0.66. Stepwise imputation from 60K to 670K markers and subsequently to sequence level did not improve the accuracy of imputation. However, imputation from higher density (670K) was considerably more accurate (about 0.90) than from medium density. Likewise, imputation in genomic regions with a low marker coverage resulted in a reduced accuracy of imputation.ConclusionsThe accuracy of imputation in horses was influenced by the size and composition of the reference panel, the marker density of the genotyping array, and the imputation software. Genotype imputation can be used to extend the limited amount of available sequence-level data from horses in order to boost the power of downstream analyses, such as genome-wide association studies, or the detection of embryonic lethal variants.
Identification and integrated analysis of lncRNAs and miRNAs in IPEC-J2 cells provide novel insight into the regulation of the innate immune response by PDCoV infection
Authors: Jiang Shan , Chen Jianfei , Li Xiuli , Ren Weike , Li Fengxiang , Wang Ting , Li Cheng , Dong Zhimin , Tian Xiangxue , Zhang Li , Wang Lili , lu Chao , Chi Jingjing , Feng Li , Yan Minghua 
Published: July 2022

Abstract
Background
Noncoding RNAs (ncRNAs), including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), are pivotal regulators involved in the pathogenic mechanism of multiple coronaviruses. Porcine deltacoronavirus (PDCoV) has evolved multiple strategies to escape the innate immune response of host cells, but whether ncRNAs are involved in this process during PDCoV infection is still unknown.

Results
In this study, the expression profiles of miRNAs, lncRNAs and mRNAs in IPEC-J2 cells infected with PDCoV at 0, 12 and 24 hours postinfection (hpi) were identified through small RNA and RNA sequencing. The differentially expressed miRNAs (DEmiRNAs), lncRNAs (DElncRNAs) and mRNAs (DEmRNAs) were screened from the comparison group of IPEC-J2 cells at 0 and 12 hpi as well as the comparison group of IPEC-J2 cells at 12 and 24 hpi. The target genes of these DEncRNAs were predicted. The bioinformatics analysis of the target genes revealed multiple significantly enriched functions and pathways. Among them, the genes that were associated with innate immunity were specifically screened. The expression of innate immunity-related ncRNAs and mRNAs was validated by RT–qPCR. Competing endogenous RNA (ceRNA) regulatory networks among innate immunity-related ncRNAs and their target mRNAs were established. Moreover, we found that the replication of PDCoV was significantly inhibited by two innate immunity-related miRNAs, ssc-miR-30c-3p and ssc-miR-374b-3p, in IPEC-J2 cells.

Conclusions
This study provides a data platform to conduct studies of the pathogenic mechanism of PDCoV from a new perspective and will be helpful for further elucidation of the functional role of ncRNAs involved in PDCoV escaping the innate immune response.
A pressure-resistant peripherally inserted central catheter is as useful as a central venous catheter for rapid fluid infusion: an in vitro study
Authors: Maki Jun , Sumie Makoto , Ide Tomoko , Nagamatsu Masako , Matsushita Katsuyuki , Shirozu Kazuhiro , Higashi Midoriko , Yamaura Ken 
Published: July 2022

Abstract
Background
Although peripherally inserted central catheters (PICCs) have been widely used, they have not been frequently used in anesthesia practice. The central venous pressure measured via PICCs are reportedly as accurate as that measured via central venous catheters (CVCs), but the findings concerning rapid infusion are unclear. This study examined whether or not pressure-resistant PICCs could be used for rapid fluid infusion.

Methods
The in-line pressure was measured in similar-sized double-lumen catheters—4-Fr PICC (55, 45 and 35 cm) and 17-G CVC (20 and 13 cm)—at flow rates of saline decided using a roller pump system. We also examined the flow rate at an in-line pressure of 300 mmHg, which is the critical pressure at which hemolysis is considered to occur during blood transfusion.

Results
The pressure-resistant PICCs obtained a high flow rate similar to that of CVCs, but the in-line pressures increased in proportion to the flow rate and catheter length. Flow rates at an intra-circuit pressure of 300 mmHg were not significantly different between the 45-cm PICC and 20-cm CVC.

Conclusion
Pressure-resistant PICCs can be used for rapid fluid infusion.
Geospatial analysis as a tool to identify target areas for Chagas disease education for healthcare providers
Authors: Pacheco Gerardo J. , Fulton Lawrence , Betancourt Jose , Shanmugam Ram , Granados Paula Stigler 
Published: July 2022

AbstractChagas Disease (CD) is a neglected zoonotic disease of the Americas. It can be fatal if not diagnosed and treated in its early stages. Using geospatial and sensitivity analysis, this study focuses on understanding how to better allocate resources and educational information to areas in the United States, specifically Texas, that have the potential for increased risk of CD cases and the associated costs of addressing the disease. ICD-9 and 10 inpatient hospital diagnostic codes were used to illustrate the salience of potentially missed CD diagnoses (e.g., cardiomyopathic diagnoses) and where these are occurring with more frequency. Coding software along with GIS and Microsoft Excel 3D mapping were used to generate maps to illustrate where there may be a need for increased statewide surveillance and screening of populations at greater risk for CD. The CD cases reported to the Texas Department of State Healthcare Services (TxDSHS) are not homogenously dispersed throughout the state but rather, reveal that the incidences are in clusters and primarily in urban areas, where there is increased access to physician care, CD research and diagnostic capabilities.
Gaps in measles vaccination coverage in Kasese district, Western Uganda: results of a qualitative evaluation
Authors: Walekhwa Abel Wilson , Musoke David , Nalugya Aisha , Biribawa Claire , Nsereko Godfrey , Wafula Solomon Tsebeni , Nakazibwe Brenda , Nantongo Mary , Odera Doreen Awino , Chiara Achangwa , Boyce Ross Mathew , Mulogo Edgar Mugema 
Published: July 2022

Abstract
Background
Despite the availability of a highly effective vaccine, measles remains a substantial public health problem in many countries including Uganda. In this study, conducted between June–August 2020 following a local outbreak, we sought to explore the factors that could affect measles vaccination coverage in rural western Uganda.

Methods
We conducted a descriptive study using qualitative data collection approaches in the Kasese district. The research team utilized purposive sampling to identify and select participants from the public health sector and district government. We conducted key informant interviews (KII) and one focus group discussion (FGD). Responses were recorded using portable electronic devices with the FGD and KII guide installed. Interviews were conducted at the health centre and district headquarters. Data was coded and analysed using ATLAS.ti version 8 software through deductive thematic analysis to identify key themes.

Results
Barriers to measles vaccination identified in this study were premised around six themes including: (i) availability of supplies and stock management, (ii) health worker attitudes and workload, (iii) financing of vaccination outreach activities, (iv) effectiveness of duty rosters (i.e., health workers’ working schedules), (v) community beliefs, and (vi) accessibility of healthcare facilities. Respondents reported frequent vaccine supply disruptions, lack of resources to facilitate transportation of health workers to communities for outreach events, and health centre staffing that did not adequately support supplemental vaccination activities. Furthermore, community dependence on traditional medicine as a substitute for vaccines and long distances traveled by caregivers to reach a health facility were mentioned as barriers to vaccination uptake.

Conclusions
Health system barriers limiting vaccination uptake were primarily logistical in nature and reflect inadequate resourcing of immunization efforts. At the same time, local beliefs favouring traditional medicine remain a persistent cultural barrier. These findings suggest an urgent need for more efficient supply management practices and resourcing of immunization outreaches in order to achieve the Uganda Ministry of Health’s targets for childhood immunization and the prevention of disease outbreaks.
Assessing the inflammatory severity of the terminal ileum in Crohn disease using radiomics based on MRI
Authors: Ding Honglei , Li Jiaying , Jiang Kefang , Gao Chen , Lu Liangji , Zhang Huani , Chen Haibo , Gao Xuning , Zhou Kefeng , Sun Zhichao 
Published: July 2022

Abstract
Background
Evaluating inflammatory severity using imaging is essential for Crohn’s disease, but it is limited by potential interobserver variation and subjectivity. We compared the efficiency of magnetic resonance index of activity (MaRIA) collected by radiologists and a radiomics model in assessing the inflammatory severity of terminal ileum (TI).

Methods
121 patients were collected from two centers. Patients were divided into ulcerative group and mucosal remission group based on the TI Crohn’s disease Endoscopic Severity Index. The consistency of bowel wall thickness (BWT), relative contrast enhancement (RCE), edema, ulcer, MaRIA and features of the region of interest between radiologists were described by weighted Kappa test and intraclass correlation coefficient (ICC), and developed receiver operating curve of MaRIA. The radiomics model was established using reproducible features of logistic regression based on arterial staging of T1WI sequences. Delong test was used to compare radiomics with MaRIA.

Results
The consistency between radiologists were moderate in BWT (ICC = 0.638), fair in edema (κ = 0.541), RCE (ICC = 0.461), MaRIA (ICC = 0.579) and poor in ulcer (κ = 0.271). Radiomics model was developed by 6 reproducible features (ICC = 0.93–0.96) and equivalent to MaRIA which evaluated by the senior radiologist (0.872 vs 0.883 in training group, 0.824 vs 0.783 in validation group, P = 0.847, 0.471), both of which were significantly higher than MaRIA evaluated by junior radiologist (AUC: 0.621 in training group, 0.557 in validation group, all, P < 0.05).

Conclusion
The evaluation of inflammatory severity could be performed by radiomics objectively and reproducibly, and was comparable to MaRIA evaluated by the senior radiologist. Radiomics may be an important method to assist junior radiologists to assess the severity of inflammation objectively and accurately.
“I had so many life-changing decisions I had to make without support”: a qualitative analysis of women’s pregnant and postpartum experiences during the COVID-19 pandemic
Authors: Ashby Grayson B. , Riggan Kirsten A. , Huang Lily , Torbenson Vanessa E. , Long Margaret E. , Wick Myra J. , Allyse Megan A. , Rivera-Chiauzzi Enid Y. 
Published: July 2022

Abstract
Background
The COVID-19 pandemic has posed profound challenges for pregnant patients and their families. Studies conducted early in the pandemic found that pregnant individuals reported increased mental health concerns in response to pandemic-related stress. Many obstetric practices changed their healthcare delivery models, further impacting the experiences of pregnant patients. We conducted a survey study to explore the ways in which COVID-19 impacted the lives of pregnant and newly postpartum people.

Methods
A mixed-methods survey was distributed to all patients ≥18 years old who were pregnant between January 1st, 2020 – April 28, 2021 in a large Midwest health system. Open-ended survey responses were analyzed for common themes using standard qualitative methodology.

Results
Among the 1182 survey respondents, 647 women provided an open-ended response. Of these, 77% were in the postpartum period. The majority of respondents identified as white, were partnered or married, and owned their own home. Respondents reported feeling greater uncertainty, social isolation, as though they had limited social and practical support, and negative mental health effects as a result of the pandemic. Many cited sudden or arbitrary changes to their medical care as a contributing factor. Though in the minority, some respondents also reported benefits from the changes to daily life, including perceived improvements to medical care, better work-life balance, and opportunities for new perspectives.

Conclusions
This large qualitative dataset provides insight into how healthcare policy and lifestyle changes impacted pregnant and postpartum people. Respondents expressed similar levels of uncertainty and mental health concerns compared to other cohorts but less overall positivity. Our findings suggest greater attention be given to the impact of pandemic-related stress on pregnant and postpartum women. As the pandemic continues, these data identify areas where investment in additional support may have the greatest impact.
A bioinformatic analysis study of m7G regulator-mediated methylation modification patterns and tumor microenvironment infiltration in glioblastoma
Authors: Wu Xinrui , Li Chuanyu , Wang Zhisu , Zhang Yundi , Liu Shifan , Chen Siqi , Chen Shuai , Liu Wangrui , Liu Xiaoman 
Published: July 2022

Abstract
Background
Glioblastoma is one of the most common brain cancers in adults, and is characterized by recurrence and little curative effect. An effective treatment for glioblastoma patients remains elusive worldwide. 7-methylguanosine (m7G) is a common RNA modification, and its role in tumors has become a research hotspot.

Methods
By searching for differentially expressed genes related to m7G, we generated a prognostic signature via cluster analysis and established classification criteria of high and low risk scores. The effectiveness of classification was validated using the Non-negative matrix factorization (NMF) algorithm, and repeatedly verified using training and test groups. The dimension reduction method was used to clearly show the difference and clinical significance of the data. All analyses were performed via R (version 4.1.2).

Results
According to the signature that included four genes (TMOD2, CACNG2, PLOD3, and TMSB10), glioblastoma patients were divided into high and low risk score groups. The survival rates between the two groups were significantly different, and the predictive abilities for 1-, 3-, and 5-year survivals were effective. We further established a Nomogram model to further examine the signature,as well as other clinical factors, with remaining significant results. Our signature can act as an independent prognostic factor related to immune-related processes in glioblastoma.

Conclusions
Our research addresses the gap in knowledge in the m7G and glioblastoma research fields. The establishment of a prognostic signature and the extended analysis of the tumor microenvironment, immune correlation, and tumor mutation burden further suggest the important role of m7G in the development and development of this disease. This work will provide support for future research.
Improving anticancer effect of aPD-L1 through lowering neutrophil infiltration by PLAG in tumor implanted with MB49 mouse urothelial carcinoma
Authors: Kim Guen Tae , Kim Eun Young , Shin Su-Hyun , Lee Hyowon , Lee Se Hee , Sohn Ki-Young , Kim Jae Wha 
Published: July 2022

Abstract
Background
The PD-L1 antibody is an immune checkpoint inhibitor (ICI) attracting attention. The third-generation anticancer drug has been proven to be very effective due to fewer side effects and higher tumor-specific reactions than conventional anticancer drugs. However, as tumors produce additional resistance in the host immune system, the effectiveness of ICI is gradually weakening. Therefore, it is very important to develop a combination therapy that increases the anticancer effect of ICI by removing anticancer resistance factors present around the tumor.

Methods
The syngeneic model was used (n = 6) to investigate the enhanced anti-tumor effect of PD-L1 antibody with the addition of PLAG. MB49 murine urothelial cancer cells were implanted into the C57BL/6 mice subcutaneously. PLAG at different dosages (50/100 mpk) was daily administered orally for another 4 weeks with or without 5 mpk PD-L1 antibody (10F.9G2). PD-L1 antibody was delivered via IP injection once a week.

Results
The aPD-L1 monotherapy group inhibited tumor growth of 56% compared to the positive group, while the PLAG and aPD-L1 co-treatment inhibited by 89%. PLAG treatment effectively reduced neutrophils infiltrating localized in tumor and converted to a tumor microenvironment with anti-tumor effective T-cells. PLAG increased tumor infiltration of CD8 positive cytotoxic T-cell populations while effectively inhibiting the infiltration of neoplastic T-cells such as CD4/FoxP3. Eventually, neutrophil-induced tumor ICI resistance was resolved by restoring the neutrophil-to-lymphocyte ratio to the normal range. In addition, regulation of cytokine and chemokine factors that inhibit neutrophil infiltration and increase the killing activity of cytotoxic T cells was observed in the tumors of mice treated with PLAG + aPD-L1.

Conclusions
PLAG effectively turned the tumor-promoting microenvironment into a tumor-suppressing microenvironment. As a molecule that increases the anti-tumor effectiveness of aPD-L1, PLAG has the potential to be an essential and effective ICI co-therapeutic agent.
Implant survival of cemented arthroplasty following failed fixation of proximal femoral fractures in patients aged 30–60 years: a retrospective study with a median follow-up of 10 years
Authors: Yu Mingliang , Yu Minji , Zhang Yaodong , Cheng Huihui , Zeng Xianshang , Li Si , Yu Weiguang 
Published: July 2022

Abstract
Background
Given the unremitting growth in the volume of failed fixations of proximal femoral fractures (PFFs) in recent years, it is predictable that total hip replacements (THRs) will be the preferred surgical procedure. The long-term survival of cemented THR (CTHR) revisions remains controversial in patients aged 30–60 years. The goal of this retrospective review was to evaluate the 10-year survival of CTHRs following prior failed primary fixations of PFFs in patients aged 30–60 years.

Methods
We retrospectively identified CTHR revisions implemented at four medical centres during 2008–2017 for a failed primary fixation of PFFs in consecutive patients aged 30–60 years. The primary endpoint was implant survival calculated using the Kaplan–Meier method with 95% confidence intervals (CIs); secondary endpoints included functional scores assessed by Harris hip scores (HHS) and main revision-related orthopaedic complications. Follow-up was executed at 1, 2, 3, and 8 years following revision and then at 1-year intervals until the revision, death, or study deadline, whichever occurred first.

Results
In total, 120 patients (120 hips) who met the eligibility criteria were eligible for follow-up. The median follow-up was 10.2 years (range, 8–12 years). Kaplan–Meier survivorship showed that implant survival with revision for any reason as the endpoint was 95% at 5 years (CI: 93–97%), 89% at 8 years (CI: 86–92%), and 86% at 10 years (CI: 83–89%). Patients treated with three hollow screws had better revision-free survival than patients treated with proximal femoral nail antirotation (PFNA), dynamic hip screw (DHS) or titanium plate plus screws (three p < 0.05). Functional scores were apt to decrease gradually, and at the final follow-up, the mean HHS was 76.9 (range, 67.4–86.4). The overall rate of main revision-related orthopaedic complications was 18.3% (22/120).

Conclusion
CTHR implemented following prior failed primary fixations of PFFs tends to afford an acceptable 10-year survival, along with advantageous HHS and a low rate of main revision-related orthopaedic complications, which may support an inclination to follow the utilisation of CTHRs, especially in revision settings for intracapsular fractures.