bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of CO2 adsorption sites on MgO nanosheets by solid-state nuclear magnetic resonance spectroscopy
Authors: Du Jia-Huan , Chen Lu , Zhang Bing , Chen Kuizhi , Wang Meng , Wang Yang , Hung Ivan , Gan Zhehong , Wu Xin-Ping , Gong Xue-Qing , Peng Luming 
Published: February 2022

AbstractThe detailed information on the surface structure and binding sites of oxide nanomaterials is crucial to understand the adsorption and catalytic processes and thus the key to develop better materials for related applications. However, experimental methods to reveal this information remain scarce. Here we show that 17O solid-state nuclear magnetic resonance (NMR) spectroscopy can be used to identify specific surface sites active for CO2 adsorption on MgO nanosheets. Two 3-coordinated bare surface oxygen sites, resonating at 39 and 42 ppm, are observed, but only the latter is involved in CO2 adsorption. Double resonance NMR and density functional theory (DFT) calculations results prove that the difference between the two species is the close proximity to H, and CO2 does not bind to the oxygen ions with a shorter O···H distance of approx. 3.0 Å. Extensions of this approach to explore adsorption processes on other oxide materials can be readily envisaged.
Isolation, characterization and comparative genomics of potentially probiotic Lactiplantibacillus plantarum strains from Indian foods
Authors: Surve Sarvesh , Shinde Dasharath B. , Kulkarni Ram 
Published: February 2022

AbstractLactiplantibacillus plantarum is one of the most diverse species of lactic acid bacteria found in various habitats. The aim of this work was to perform preliminary phenotypic and genomic characterization of two novel and potentially probiotic L. plantarum strains isolated from Indian foods, viz., dhokla batter and jaggery. Both the strains were bile and acid tolerant, utilized various sugars, adhered to intestinal epithelial cells, produced exopolysaccharides and folate, were susceptible for tetracycline, erythromycin, and chloramphenicol, did not cause hemolysis, and exhibited antimicrobial and plant phenolics metabolizing activities. The genetic determinants of bile tolerance, cell-adhesion, bacteriocins production, riboflavin and folate biosynthesis, plant polyphenols utilization, and exopolysaccharide production were found in both the strains. One of the strains contained a large number of unique genes while the other had a simultaneous presence of glucansucrase and fructansucrase genes which is a rare trait in L. plantarum. Comparative genome analysis of 149 L. plantarum strains highlighted high variation in the cell-adhesion and sugar metabolism genes while the genomic regions for some other properties were relatively conserved. This work highlights the unique properties of our strains along with the probiotic and technically important genomic features of a large number of L. plantarum strains.
Modular multimodal platform for classical and high throughput light sheet microscopy
Authors: Bernardello Matteo , Gualda Emilio J. , Loza-Alvarez Pablo 
Published: February 2022

AbstractLight-sheet fluorescence microscopy (LSFM) has become an important tool for biological and biomedical research. Although several illumination and detection strategies have been developed, the sample mounting still represents a cumbersome procedure as this is highly dependent on the type of sample and often this might be time consuming. This prevents the use of LSFM in other promising applications in which a fast and straightforward sample-mounting procedure and imaging are essential. These include the high-throughput research fields, e.g. in drug screenings and toxicology studies. Here we present a new imaging paradigm for LSFM, which exploits modularity to offer multimodal imaging and straightforward sample mounting strategy, enhancing the flexibility and throughput of the system. We describe its implementation in which the sample can be imaged either as in any classical configuration, as it flows through the light-sheet using a fluidic approach, or a combination of both. We also evaluate its ability to image a variety of samples, from zebrafish embryos and larvae to 3D complex cell cultures.
Implementation of an integrated home internet of things system for vulnerable older adults using a frailty-centered approach
Authors: Baek Ji Yeon , Na Se Hee , Lee Heayon , Jung Hee-Won , Lee Eunju , Jo Min-Woo , Park Yu Rang , Jang Il-Young 
Published: February 2022

AbstractAlthough integrated home internet of things (IoT) services can be beneficial, especially for vulnerable older adults, the hurdle of usability hinders implementation of the technology. This study aimed to evaluate the practical usability of home IoT services in older adults, by frailty status, and to determine the potential obstacles. From August 2019 to July 2020, we randomly selected 20 vulnerable older adults (prefrailty group [n = 11], and frailty group [n = 9]) who had already been identified as needing home IoT services in a community-based prospective cohort study, the Aging Study of the Pyeongchang Rural Area. Integrated home IoT services were provided for 1 year, and a face-to-face survey evaluating usability and satisfaction of each service was conducted. The usability of the integrated home IoT services declined gradually throughout the study. However, prefrail participants showed higher usability than frail older adults (difference-in-difference = − 19.431, p = 0.012). According to the frailty status, the change in usability for each service type also showed a different pattern. During the 12-month study period, the service with the highest satisfaction converged from various service needs to light control by remote control (77.8%) in the prefrailty group and automatic gas circuit breaker (72.7%) in the frailty group. For wider implementation of home IoT services, organizing services expected to have high usability and satisfaction based on user’s frailty status is crucial. Also, providing education before service implementation might help older adults coping with digital literacy.
Ambulatory electrocardiography, heart rate variability, and pharmacologic stress testing in cats with subclinical hypertrophic cardiomyopathy
Authors: Walker Ashley L. , Ueda Yu , Crofton Amanda E. , Harris Samantha P. , Stern Joshua A. 
Published: February 2022

AbstractThe utility of ambulatory electrocardiography (AECG) to evaluate cats with subclinical hypertrophic cardiomyopathy (HCM) for arrhythmias and heart rate variability (HRV) is not well defined but may provide information regarding risk stratification. This prospective study used AECG to evaluate ectopy and HRV in subclinical HCM cats compared to healthy controls and is the first to implement a pharmacologic cardiac stress test. Twenty-three purpose-bred, Maine coon cross cats (16 HCM, 7 control) underwent 48-h of continuous AECG. Terbutaline (0.2–0.3 mg/kg) was administered orally at 24 and 36 h. Heart rate, ectopy frequency and complexity and HRV parameters, including standard deviation of normal R-R intervals (SDNN), were compared pre-terbutaline and post-terbutaline and across phenotype, genotype and sex. Genotype for an HCM-causative mutation was significantly associated with the frequency of supraventricular (P = 0.033) and ventricular (P = 0.026) ectopy across all cats. Seven HCM cats and zero healthy cats had a sinus arrhythmia. Mean heart rate was significantly higher post-terbutaline (p < 0.0001). HCM cats had significantly greater HRV compared to controls (SDNN: p = 0.0006). Male cats had significantly higher HRV (SDNN: p = 0.0001) and lower mean heart rates (p = 0.0001). HRV decreased post-terbutaline (SDNN: p = 0.0008) and changes in HRV observed between sexes were attenuated by terbutaline.
XSSJS inhibits hepatic fibrosis by promoting the miR-29b-3p/VEGFA axis in vitro and in vivo
Authors: Zhang Tianyao , Yang Yu , Wang Baojia , Wang Long , Wang Dong , Cao Ning , Shi Jinyu 
Published: February 2022

Abstract
Hepatic pathological angiogenesis (HPA) is the key event of hepatic fibrosis (HF). Xueshisanjia powder (XSSJS), a Chinese herbal compound, is beneficial for alleviating pathological angiogenesis of hepatic tissue. The present study attempts to reveal the effect and mechanism of XSSJS via regulating miR-29b-3p/VEGFA axis against pathological angiogenesis in HF. In in vitro model, human embryonic kidney 293T cells were transfected with miR-29b-3p mimics, whereby the expression of miR-29b-3p was tested by real-time quantitative polymerase chain reaction (RT-qPCR), ensued by Luciferase assay determining the relationship between miR-29b-3p and vascular endothelial cell growth factor A (VEGFA). In addition, miR-29b-3p mimic transfected into the activated hepatic stellate cell T6 (HSC-T6). The Cell-Counting-Kit 8 (CCK8) and 5-Bromodeoxyuridine (BrdU) staining were first utilized to detect the antiproliferative efficiency of XSSJS following the XSSJS compound serum intervention, and then used to observe the expression of transforming growth factor-β (TGF-β), VEGFA, platelet-derived growth factor (PDGF) via RT-PCR, Western blot (WB), and Immunofluorescence (IF) methods. During the in vivo model, XSSJS with boil-free granules were fed to Wistar rats with liver fibrosis caused by intraperitoneal injection of pig serum followed by the transfection of miR-29b-3p adeno-associated virus (AAV). Hematoxylin–Eosin (HE) staining was used for histopathology assessment. The expression of miR-29b-3p, VEGFA, PDGF, TGF-β have been investigated in liver tissue using RT-PCR, WB, IF. The results verified that XSSJS could up-regulate miR-29b-3p and suppress the expression of VEGFA, PDGA, and TGF-β. In mechanism, miR-29b-3p primarily targeted the 3′UTR of VEGFA. In conclusion, XSSJS could modulate miR-29b-3p/VEGFA axis to inhibit the pathological angiogenesis of HF.
Work Setting Effects on Speech-Language Pathology Practice: Implications for Identification of Children With Specific Language Impairment
Authors: Selin Claire M. , Rice Mabel L. , Girolamo Teresa M. , Wang Chien J. 
Published: February 2022

Purpose:Most research on language acquisition and impairments is neutral to work setting; however, work settings (e.g., schools, health care) are expected to differ in alignment with overlaid workplace models (e.g., education, medical). These differences may affect clinical service provision for individuals with specific language impairment (SLI). This article evaluates potential effects of work setting on top-down advocacy initiatives and clinical service provision for children with symptoms of SLI.Method:Speech-language pathologists serving pediatric populations in health care–based (n= 140) and school-based (n= 423) work settings completed a three-part survey: (a) participant demographics, (b) report of case/workload and practice patterns, and (c) clinical vignettes and eligibility belief. Data analysis included descriptives and chi-square tests.Results:The work setting groups reported differences in eligibility terminology, eligibility criteria, and practice patterns from the point of referral through discharge. The reported differences aligned with overlaid workplace models. As compared to the school-based group, health care–based participants reported fewer eligibility restrictions in the workplace, agreed more often with a belief in less restrictive eligibility criteria, and reported more sensitive clinical decisions when operating under neutral workplace circumstances. Despite these findings, health care–based participants reported a smaller proportion of individuals with language impairment only on their caseload.Discussion:Work setting variations influence the underidentification of individuals with SLI for speech-language pathology services. Differences in responses by workplace indicate the need for unique and targeted advocacy efforts. Shifting diagnostic terminology and criteria will be insufficient in closing the gap unless advocacy efforts also address speech-language pathologists' workplace realities.
A Systematic Review and Meta-Analysis of the Language Skills of Youth Offenders
Authors: Chow Jason C. , Wallace Erin Stehle , Senter Reed , Kumm Skip , Mason Carolyn Q. 
Published: February 2022

Purpose:This systematic review and meta-analysis estimates the overall language skills of youth offenders involved with the juvenile justice system. Given the importance of this population, identifying avenues through which we can increase the likelihood of successful interventions is a necessary societal effort.Method:Eighteen studies, representing data from 3,304 individuals, contributed 82 effect sizes to the current analytic sample. We used random-effects models to estimate the overall mean effect size metric to address each research question and fit meta-regression models for each moderator analysis.Results:Results yielded that youth offenders presented with significantly lower language skills than their nonoffending peers (g= −1.26). Furthermore, high proportions of the present meta-analytic sample were classified as youth with moderate (50%) and severe (10%) language disorders. In general, differences in language skills did not vary as a function of age, gender, or language measure type. We did detect significant differences as a function of sample country and type of peer comparison group.Conclusions:This meta-analysis reports on the significantly compromised language skills of youth offenders. We conclude with a discussion of the findings and consideration of the implications for research and practice.
Reliability of the Penetration–Aspiration Scale and Temporal and Clearance Measures in Poststroke Dysphagia: Videofluoroscopic Analysis From the Swallowing Treatment using Electrical Pharyngeal Stimulation Trial
Authors: Everton Lisa F. , Benfield Jacqueline K. , Michou Emilia , Hamdy Shaheen , Bath Philip M. 
Published: February 2022

Purpose:
Information on reliability of outcome measures used to assess the effectiveness of interventions in dysphagia rehabilitation is lacking, particularly when used by different research groups. Here, we report on reliability of the penetration–aspiration scale (PAS) and temporal and clearance measures, determined using videofluoroscopy.

Method:
Secondary analysis used videofluoroscopies from the Swallowing Treatment using Electrical Pharyngeal Stimulation trial in subacute stroke. PAS scores (719 scores from 18 participants) were evaluated and compared to the original PAS scores from the trial. Five conditions were assessed, including reliability for every swallow and overall mean of the worst PAS score. Operational rules for assessing temporal and clearance measures were also developed using the same data, and reliability of these rules was assessed. Reliability of component-level and derivative-level scores was assessed using the intraclass correlation coefficient (ICC) and weighted kappa.

Results:
Image quality was variable. Interrater reliability for the overall mean of the worst PAS score was excellent (ICC = .914, 95% confidence interval [CI] [.853, .951]) but moderate for every swallow in the bolus (ICC = .743, 95% CI [.708, .775]). Intrarater reliability for PAS was excellent (all conditions). Excellent reliability (both inter- and intrarater > .90) was seen for temporal measures of stage transition duration (ICC = .998, 95% CI [.993, .999] and ICC = .995, 95% CI [.987, .998], respectively) as well as initiation of laryngeal closure and pharyngeal transit time and all individual swallow events. Strong scores were obtained for some clearance measures; others were moderate or weak.

Conclusions:
Interrater reliability for PAS is acceptable but depends on how the PAS scores are handled in the analysis. Interrater reliability for most temporal measures was high, although some measures required additional training. No clearance measures had excellent reliability.

Supplemental Material:

https://doi.org/10.23641/asha.19090088
Delivery of Speech-Language Therapy and Audiology Services Across the World at the Start of the COVID-19 Pandemic: A Survey
Authors: Van Eerdenbrugh Sabine , Schraeyen Kirsten , Leysen Heleen , Mostaert Charlotte , D'haenens Wendy , Vandenborre Dorien 
Published: February 2022

Purpose:Speech-language pathologists (SLPs) and audiologists from around the world were forced to enter the world of telepractice at the start of the COVID-19 pandemic. This study investigated which types of applications SLPs and audiologists used most frequently at that time. It also examined what the main obstacles then were to provide speech, language, and hearing services through telepractice.Method:A short electronic survey with 13 questions was distributed around the world. In total, 1,466 surveys from SLPs and audiologists from 40 countries were used for the analysis. Most of them (77.4%) delivered care through online real-time communication. A minority (40.1%) also delivered care through videos or exercises that they sent to their clients, 37.8% delivered through face-to-face intervention in the same room, 30.0% delivered through telephone without video, and 21.5% provided distant computer-based treatment.Results:The most frequently used applications were those that establish synchronous video communication with the client (60.5%). SLPs and audiologists reported using applications to create exercises more frequently than applications that contain exercises or training (15.0% vs. 12.0%). The most reported obstacle (31.2%) referred to technical problems (poor Internet connection, poor quality, or poor access to resources). Other frequently reported obstacles included the difficulty to perform assessment or treatment procedures (13.8%), concentration issues during sessions (12.4%), and lack of interaction between professional and client or patient (10.9%).Conclusions:Many SLPs and audiologists reported using telepractice technology, mainly in the form of real-time videoconferencing. However, existing barriers included technical problems such as poor Internet connection.
SimAb: A simple, fast, and flexible model to assess the effects of planet formation on the atmospheric composition of gas giants
Authors: Khorshid N. , Min M. , Désert J. M. , Woitke P. , Dominik C. 
Published: February 2022

Context. The composition of exoplanet atmospheres provides us with vital insight into their formation scenario. Conversely, planet formation processes shape the composition of atmospheres and imprint their specific signatures. In this context, models of planet formation containing key formation processes help supply clues to how planets form. This includes constraints on the metallicity and carbon-to-oxygen ratio (C/O ratio) of the planetary atmospheres. Gas giants in particular are of great interest due to the amount of information we can obtain about their atmospheric composition from their spectra, and also due to their relative ease of observation.
Aims. We present a basic, fast, and flexible planet formation model, called Simulating Abundances (SimAb), that forms giant planets and allows us to study their primary atmospheric composition soon after their formation.
Methods. In SimAb we introduce parameters to simplify the assumptions about the complex physics involved in the formation of a planet. This approach allows us to trace and understand the influence of complex physical processes on the formed planets. In this study we focus on four different parameters and how they influence the composition of the planetary atmospheres: initial protoplanet mass, initial orbital distance of the protoplanet, planetesimal ratio in the disk, and dust grain fraction in the disk.
Results. We focus on the C/O ratio and the metallicity of the planetary atmosphere as an indicator of their composition. We show that the initial protoplanet core mass does not influence the final composition of the planetary atmosphere in the context of our model. The initial orbital distance affects the C/O ratio due to the different C/O ratios in the gas phase and the solid phase at different orbital distances. Additionally, the initial orbital distance together with the amount of accreted planetesimals cause the planet to have subsolar or supersolar metallicity. Furthermore, the C/O ratio is affected by the dust grain fraction and the planetesimal ratio. Planets that accrete most of their heavy elements through dust grains will have a C/O ratio close to the solar C/O ratio, while planets that accrete most of their heavy elements from the planetesimals in the disk will end up with a C/O ratio closer to the C/O ratio in the solid phase of the disk.
Conclusions. By using the C/O ratio and metallicity together we can put a lower and upper boundary on the initial orbital distance where supersolar metallicity planets are formed. We show that planetesimals are the main source for reaching supersolar metallicity planets. On the other hand, planets that mainly accrete dust grains will show a more solar composition. Supersolar metallicity planets that initiate their formation farther than the CO ice line have a C/O ratio closer to the solar value.
Tracing pebble drift and trapping using radial carbon depletion profiles in protoplanetary disks
Authors: Sturm J. A. , McClure M. K. , Harsono D. , Facchini S. , Long F. , Kama M. , Bergin E. A. , van Dishoeck E. F. 
Published: February 2022

Context. The composition of planets may be largely determined by the chemical processing and accretion of icy pebbles in protoplanetary disks. Recent observations of protoplanetary disks hint at wide-spread depletion of gaseous carbon. The missing volatile carbon is likely frozen in CO and/or CO2 ice on grains and locked into the disk through pebble trapping in pressure bumps or planetesimals.
Aims. We aim to measure the total elemental C/H ratio in the outer region of seven disks, four of which have been previously shown to be depleted of carbon gas interior to 0.1 AU through near-infrared spectroscopy.
Methods. We present the results of the first successful Atacama Compact Array (ACA) [C I] J = 1−0 mini-survey of seven protoplanetary disks. Using tailored azimuthally symmetric Dust And LInes thermo-chemical disk models, supported by the [C I] J = 1−0 and resolved CO isotopologue data, we determine the system-averaged elemental volatile carbon abundance in the outer disk of three sources.
Results. Six out of the seven sources are detected in [C I] J = 1−0 with ACA, four of which show a distinct disk component. Based on the modeling we find severe cold gaseous carbon depletion by a factor of 157+17-15 in the outer disk of DL Tau and moderate depletion in the outer disks of DR Tau and DO Tau, by factors of 5+2-1 and 17+3-2, respectively. The carbon abundance is in general expected to be higher in the inner disk if carbon-rich ices drift on large grains toward the star. Combining the outer and inner disk carbon abundances, we demonstrate definitive evidence for radial drift in the disk of DL Tau, where the existence of multiple dust rings points to either short-lived or leaky dust traps. We find dust locking in the compact, smooth disks of DO Tau and DR Tau, which hints at unresolved dust substructure. Comparing our results with the inner and outer disk carbon depletion around stars of different ages and luminosities, we identify an observational evolutionary trend in gaseous carbon depletion that is consistent with dynamical models of CO depletion processes.
Conclusions. The transport efficiency of solids in protoplanetary disks can significantly differ from what we expect based on the current resolved substructure in the continuum observations. This has important implications for our understanding of the impact of radial drift and pebble accretion on planetary compositions.