bluuebunny/crossref_metadata_2025_split huggingface dataset:
Undetected ophthalmological disorders in Parkinson’s disease
Authors: Borm Carlijn D. J. M. , Werkmann Mario , de Graaf Debbie , Visser Femke , Hofer Arno , Peball Marina , Smilowska Katarzyna , Putz Diana , Seppi Klaus , Poewe Werner , Hoyng Carel , Bloem Bastiaan R. , Theelen Thomas , de Vries Nienke M. 
Published: March 2022

Abstract
Background
Ophthalmological disorders are common and frequently disabling for people with Parkinson’s disease (PD). However, details on the prevalence, severity and impact of ophthalmological disorders thus far lacking. We aimed to identify PD patients with undetected ophthalmological disorders in a large cross-sectional, observational study.

Methods
We previously delivered a screening questionnaire to detect ophthalmological symptoms (Visual impairment in PD questionnaire; VIPD-Q) to 848 patients. Here, we report on a subgroup of 102 patients who received complete ophthalmological assessment aimed at identifying clinically relevant ophthalmological diseases, which were classified as either vison-threatening or not. Impact on daily life functioning was measured using the visual functioning-25 questionnaire (VFQ-25) and fall frequency.

Results
Almost all patients (92%) had one or more clinically relevant ophthalmological disorders. Of those, 77% had a potentially vision-threatening disease, while 34% had a potentially treatable ophthalmological disease which impacted on quality of life. The most prevalent ophthalmological disorders were dry eyes (86%), ocular misalignment (50%) and convergence insufficiency (41%). We found a weak but significant association between clinically relevant ophthalmological diseases and both fall frequency (R2 = 0.15, p = 0.037) and VFQ-25 score (R2 = 0.15, p = 0.02). The VIPD-Q could not correctly identify patients with relevant ophthalmological disorders.

Conclusions
Surprisingly, in our study sample, many participants manifested previously undetected ophthalmological diseases, most of which threatened vision, impacted on daily life functioning and were amenable to treatment. Screening for these ophthalmological disorders using a questionnaire asking about symptoms seems insufficient. Instead, episodic ophthalmological assessments should be considered for PD patients, aiming to identify vision-threatening yet treatable diseases.

Trial registration
Dutch Trial Registration, NL7421.
Hemidivisional vector planning to reduce and regularize irregular astigmatism by laser treatment
Authors: Alpins Noel , Ong James K. Y. , Stamatelatos George 
Published: March 2022

Abstract
Purpose
To demonstrate how hemidivisional vector planning of refractive laser treatments of astigmatism can be used to directly address idiopathic corneal irregular astigmatism that has an asymmetrical, non-orthogonal bow tie topography appearance.

Design
Case study.

Methods
The cornea is conceptually divided into two hemidivisions along the flat meridian of the corneal topographic astigmatism (CorT), which means that each hemidivision will approximately correspond to one lobe of the asymmetric, non-orthogonal topographic bow tie. An astigmatism reduction treatment can then be planned separately for each hemidivision using the vector planning technique, based on both its two hemidivisional CorT measures and common manifest refractive cylinder. The remaining irregularity is then regularized, and the junctional zone smoothed across the flat meridian. The final intended treatment thus combines hemidivisional astigmatism reduction and regularization of the corneal astigmatism and spherical refractive error in one treatment application. This could be applied to LASIK, PRK, SMILE, and Transepithelial PRK procedures using Designer Cornea® software.

Results
A theoretical treatment profile is derived from an actual example of a cornea with idiopathic asymmetric non-orthogonal astigmatism. The three steps of the derivation are as follows: (i) astigmatism reduction through the use of the vector planning technique; (ii) regularization, and (iii) smoothing across the hemidivisional midline.

Conclusions
Hemidivisional vector planning treatments could potentially both reduce and regularize asymmetric non-orthogonal astigmatism. These treatments can be systematically customized to account for qualitative and quantitative differences between the two corneal hemidivisions at the same time as correction of coexistent myopia or hyperopia.
Ultrastructural analysis of explanted CyPass microstents and correlation with clinical findings
Authors: Hübner Lisa , Schlötzer-Schrehardt U. , Weller J. M. , Hohberger B. , Mardin C. Y. , Lämmer R. 
Published: March 2022

Abstract

Purpose
The purpose of this study was to obtain insight into cellular processes after CyPass microstent implantation into the supraciliary space. With this knowledge, we expected to find some reason for surgical failure.

Methods
Nine CyPass microstents of 8 patients with primary open-angle glaucoma (n = 1), pseudoexfoliation glaucoma (n = 5), uveitic glaucoma (n = 1), and posttraumatic open-angle glaucoma (n = 1) were explanted due to recurrence of IOP elevation, corneal decompensation, or persistent hypotony. The explants were processed for light and transmission electron microscopy.

Results
Fibrotic material, consisting of collagen fibrils, microfibrils, pseudoexfoliation fibrils produced by activated fibroblasts, was detected in the stent lumen of 4/5 pseudoexfoliation glaucoma patients and also in posttraumatic open-angle glaucoma. Fibrotic material was also present on the outer surface and within fenestrations of the majority of stents. Complete absence of fibrotic reaction was noticed in 3 of 9 microstents.

Conclusion
Although MIGS is known to be less invasive than conventional surgery, implants placed in the suprachoroidal space may be adversely affected by a fibrotic tissue reaction resulting in implant failure. Understanding mechanisms and risk factors leading to fibrotic scarring following antiglaucomatous surgery may help to develop novel strategies that improve surgical outcome.
Preoperative embolisation of brain arteriovenous malformations: a systematic review and meta-analysis
Authors: Brosnan Conor , Amoo Michael , Javadpour Mohsen 
Published: March 2022

AbstractPreoperative embolisation is a commonly performed adjunct to microsurgical excision of brain arteriovenous malformations (bAVMs), with aims such as lessening the technical difficulty of the microsurgical procedure, reducing operative time, decreasing blood loss, and improving patient functional outcomes. We aim to perform a systematic review of randomised trials and cohort studies evaluating preoperative embolisation of bAVMs published between 01 January 2000 and 31 March 2021 and appraise its role in clinical practice. A MEDLINE search was performed, and articles reporting on outcomes following preoperative embolisation, as an adjunct to microsurgery, were eligible for inclusion. PRISMA reporting and Cochrane Handbook guidelines were followed. The primary outcome measure was the risk of complications associated with preoperative embolisation. The study was registered with PROSPERO (CRD42021244231). Of the 1661 citations, 8 studies with 588 patients met predefined inclusion criteria. No studies specifically compared outcomes of surgical excision of bAVMs between those with and without preoperative embolisation. Spetzler Martin (SM) grading was available in 301 cases. 123 of 298 (41⋅28%) patients presented with haemorrhage. Complications related to embolisation occurred in 175/588 patients (29.4%, 95% CI 19.6–40.2). Permanent neurological deficits occurred in 36/541 (6%, 95% CI 3.9–8.5) and mortality in 6/588 (0.41%, 95% CI 0–1.4). This is the first systematic review evaluating preoperative embolisation of bAVMs. Existing studies assessing this intervention are of poor quality. Associated complication rates are significant. Based on published literature, there is currently insufficient evidence to recommend preoperative embolisation of AVMs. Further studies are required to ascertain if there are benefits of this procedure and if so, in which cases.
Rapid X-Ray-Based 3-D Finite Element Modeling of Medial Knee Joint Cartilage Biomechanics During Walking
Authors: Jahangir Sana , Mohammadi Ali , Mononen Mika E. , Hirvasniemi Jukka , Suomalainen Juha-Sampo , Saarakkala Simo , Korhonen Rami K. , Tanska Petri 
Published: March 2022

AbstractFinite element (FE) modeling is becoming an increasingly popular method for analyzing knee joint mechanics and biomechanical mechanisms leading to osteoarthritis (OA). The most common and widely available imaging method for knee OA diagnostics is planar X-ray imaging, while more sophisticated imaging methods, e.g., magnetic resonance imaging (MRI) and computed tomography (CT), are seldom used. Hence, the capability to produce accurate biomechanical knee joint models directly from X-ray imaging would bring FE modeling closer to clinical use. Here, we extend our atlas-based framework by generating FE knee models from X-ray images (N = 28). Based on measured anatomical landmarks from X-ray and MRI, knee joint templates were selected from the atlas library. The cartilage stresses and strains of the X-ray-based model were then compared with the MRI-based model during the stance phase of the gait. The biomechanical responses were statistically not different between MRI- vs. X-ray-based models when the template obtained from X-ray imaging was the same as the MRI template. However, if this was not the case, the peak values of biomechanical responses were statistically different between X-ray and MRI models. The developed X-ray-based framework may pave the way for a clinically feasible approach for knee joint FE modeling.
An adaptive kernel-split quadrature method for parameter-dependent layer potentials
Authors: Fryklund Fredrik , Klinteberg Ludvig af , Tornberg Anna-Karin 
Published: March 2022

AbstractPanel-based, kernel-split quadrature is currently one of the most efficient methods available for accurate evaluation of singular and nearly singular layer potentials in two dimensions. However, it can fail completely for the layer potentials belonging to the modified Helmholtz, modified biharmonic, and modified Stokes equations. These equations depend on a parameter, denoted α, and kernel-split quadrature loses its accuracy rapidly when this parameter grows beyond a certain threshold. This paper describes an algorithm that remedies this problem, using per-target adaptive sampling of the source geometry. The refinement is carried out through recursive bisection, with a carefully selected rule set. This maintains accuracy for a wide range of the parameter α, at an increased cost that scales as $\log \alpha $
log
α
. Using this algorithm allows kernel-split quadrature to be both accurate and efficient for a much wider range of problems than previously possible.
What are ecological mechanisms? Suggestions for a fine-grained description of causal mechanisms in invasion ecology
Authors: Heger Tina 
Published: March 2022

AbstractInvasion ecology addresses the spread of species outside of their native ranges. A central aim of this field is to find mechanistic explanations for why species are able to establish and spread in an area in which they did not evolve. Usually it remains unclear, however, what exactly is meant by ‘mechanistic explanation’ or ‘mechanism’. The paper argues that the field can benefit from the philosophical discussion of what a mechanism is. Based on conceptions of mechanisms as processes in concrete systems, causal mechanisms can be defined as one type of mechanism, representing recurring networks of causal relationships. With the example of a well-known hypothesized mechanism in invasion ecology, namely enemy release, the paper demonstrates how such causal mechanisms can be depicted as causal network diagrams. This approach could facilitate the development of step-by-step explanations, enhance clear argumentation and allow for more precise linkage of empirical tests to theory. Challenges to assessing the empirical relevance of hypothesized mechanisms are discussed, and suggestions are made concerning how the proposed approach could help in overcoming some of them.
Indicators to assess preservice teachers’ digital competence in security: A systematic review
Authors: Torres-Hernández Norma , Gallego-Arrufat María-Jesús 
Published: March 2022

AbstractThe goal of this review is to analyse the state of inquiry in the field of digital competence in security in initial teacher education, via indicators to assess preservice teachers’ digital competence in security, in order to help find opportunities to improve their competence level. Following the parameters defined in the PRISMA declaration, the review uses a bibliographic research methodology to explore the WoS, Scopus and ERIC databases. After a search identifying a sample of 31 scholarly articles published between 2010 and 2021, we analyse the information obtained using descriptive statistics and content analysis. The results show a predominance of empirical research in the European context. These studies are quantitative and tend to use questionnaires. Our conclusion proposes the need to train preservice teachers in data protection and privacy, searching for and using Internet images with authorship screening, use of open software programs, and respect for online communication norms, as well as ethical and responsible technology use. All of these issues are implicitly and transversally linked to the area of digital competence in security.
Exploring students’ expectations of learning analytics: A person-centered approach
Authors: Viberg Olga , Engström Linda , Saqr Mohammed , Hrastinski Stefan 
Published: March 2022

AbstractIn order to successfully implement learning analytics (LA), we need a better understanding of student expectations of such services. Yet, there is still a limited body of research about students’ expectations across countries. Student expectations of LA have been predominantly examined from a view that perceives students as a group of individuals representing homogenous views. This study examines students’ ideal (i.e., representing their wanted outcomes) and predicted expectations (i.e., unveiling what they realistically expect the LA service is most likely to be) of LA by employing a person-centered approach that allows exploring the heterogeneity that may be found in student expectations. We collected data from 132 students in the setting of Swedish higher education by means of an online survey. Descriptive statistics and Latent Class Analysis (LCA) were used for the analysis. Our findings show that students’ ideal expectations of LA were considerably higher compared to their predicted expectations. The results of the LCA exhibit that the Swedish students’ expectations of LA were heterogeneous, both regarding their privacy concerns and their expectations of LA services. The findings of this study can be seen as a baseline of students’ expectations or a cross-sectional average, and be used to inform student-centered implementation of LA in higher education.
Potential fluoride exposure from selected food crops grown in high fluoride soils in the Makueni County, south-eastern Kenya
Authors: Gevera Patrick Kirita , Cave Mark , Dowling Kim , Gikuma-Njuru Peter , Mouri Hassina 
Published: March 2022

AbstractMakueni County, located in south-eastern Kenya, faces challenges such as limited potable water and restricted food supplies as the result of semi-aridity. High fluoride (F) concentrations have been reported in drinking water with resultant dental fluorosis affecting the local population. To determine the potential F exposure through the consumption of food crops grown in the area, F concentration was assessed in the main five locally grown and consumed crops. Additionally, the water-soluble F fraction was determined from 30 soil samples with mineralogical determination of 20 samples. Mean F concentration in the food crops was in the order; 700, 288, 71.2, 36.6, and 29 mg/kg in kale, cowpeas leaves, green grams, cowpeas (legume portion), and maize, respectively. The F concentration in farm soils ranged from 0 to 3.47 mg/kg (mean of 0.87 mg/kg) and showed a significant strong positive correlation (p = 0.03, r = 0.89) with F values in the crops. Apatite, muscovite, and biotite were identified as the F-rich minerals present. While considering two hypothetical F absorption fractions (75 and 100%), the estimated average daily dose (EADD) of F from consuming the crops ranged between 0.004 and 65.17 mg/kg/day where the highest values were from the vegetables. Most of these values were higher than the F reference dose (RfD) of 0.06 mg/kg. The estimated EADD values of several hypothetical meals prepared from the analyzed crops revealed that steamed kale and maize porridge pose the highest health risk of F associated diseases to the local population, whereas boiled cowpeas pose no health risk. Children, due to their higher daily energy requirement and low body weight, were the most vulnerable group at risk of high daily F intake relative to the RfD. These results suggest that consumption of the analyzed food crops in Makueni County may significantly contribute to F related diseases in the local population. This creates a food security issue for the area because of the potential health risks associated with these crops which are highly relied upon in the semi-arid area with a limited selection of food crops available and viable to grow.
Nonlinear gravity electro-capillary waves in two-fluid systems: solitary and periodic waves and their stability
Authors: Broadley H. , Papageorgiou D. T. 
Published: March 2022

AbstractStarting from the Euler equations governing the flow of two immiscible incompressible fluids in a horizontal channel, allowing gravity and surface tension, and imposing an electric field across the channel, a nonlinear long-wave analysis is used to derive a $$2\times 2$$

2
×
2

system of evolution equations describing the interface position and a modified tangential velocity jump across it. Travelling waves of permanent form are shown to exist and are constructed in the periodic case producing wave trains and the infinite case yielding novel gravity electro-capillary solitary waves. Various regimes are analysed including a hydrodynamically passive but electrically active upper layer, pairs of perfect dielectric fluids and a perfectly conducting lower fluid. In all cases, the presence of the field produces both depression and elevation waves travelling at the same speed, for given sets of parameters. The stability of the non-uniform travelling waves is investigated by numerically solving appropriate linearised eigenvalue problems. It is found that depression waves are neutrally stable whereas elevation ones are unstable unless the surface tension is large. Stability or instability is shown to be linked mathematically to the type of local eigenvalues of the nonlinear flux matrix used to obtain travelling and solitary waves; if these are real (hyperbolic flux matrix), the system is stable, and if they are complex (elliptic), the system is unstable. The latter is a manifestation of Kelvin–Helmholtz instability in electrified flows.
One Heresy and One Orthodoxy: On Dialetheism, Dimathematism, and the Non-normativity of Logic
Authors: Wansing Heinrich 
Published: March 2022

AbstractIn this paper, Graham Priest’s understanding of dialetheism, the view that there exist true contradictions, is discussed, and various kinds of metaphysical dialetheism are distinguished between. An alternative to dialetheism is presented, namely a thesis called ‘dimathematism’. It is pointed out that dimathematism enables one to escape a slippery slope argument for dialetheism that has been put forward by Priest. Moreover, dimathematism is presented as a thesis that is helpful in rejecting the claim that logic is a normative discipline.
Long-unburnt habitat is critical for the conservation of threatened vertebrates across Australia
Authors: von Takach Brenton , Jolly Chris J. , Dixon Kelly M. , Penton Cara E. , Doherty Tim S. , Banks Sam C. 
Published: March 2022

AbstractContextIncreases in fire frequency, intensity and extent are occurring globally. Relative to historical, Indigenous managed conditions, contemporary landscapes are often characterised by younger age classes of vegetation and a much smaller representation of long-unburnt habitat.ObjectivesWe argue that, to conserve many threatened vertebrate species in Australia, landscape management should emphasise the protection of existing long-unburnt patches from fire, as well as facilitate the recruitment of additional long-unburnt habitat, while maintaining historically relevant age distributions of more recently burned patches.MethodsWe use a range of case studies and ecosystem types to illustrate three lines of evidence: (1) that many threatened vertebrate species depend on mid- to late-successional ecosystem attributes; (2) disturbance to long-unburnt habitat tends to increase risk of future disturbance and ecosystem collapse; and (3) contemporary landscapes exhibit a range of characteristics that differ to historical conditions and require context-specific management.ConclusionsIt is crucial that we adequately consider the implications of altered contemporary landscapes for management activities that aim to conserve threatened vertebrates. Contemporary landscapes often lack a range of critical structural and compositional components typical of late-successional habitat that are required for the persistence of threatened vertebrates. We need to shift towards strategic, objective-driven approaches that identify and protect long-unburnt habitats and promote their recruitment to enable recovery of many declining and threatened species.
Arbitrarily high-order energy-conserving methods for Poisson problems
Authors: Amodio Pierluigi , Brugnano Luigi , Iavernaro Felice 
Published: March 2022

AbstractIn this paper, we are concerned with energy-conserving methods for Poisson problems, which are effectively solved by defining a suitable generalization of HBVMs, a class of energy-conserving methods for Hamiltonian problems. The actual implementation of the methods is fully discussed, with a particular emphasis on the conservation of Casimirs. Some numerical tests are reported, in order to assess the theoretical findings.