bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vulnerabilities of radiomic features to respiratory motion on four‐dimensional computed tomography‐based average intensity projection images: A phantom study
Authors: Adachi Takanori , Nagasawa Ryoko , Nakamura Mitsuhiro , Kakino Ryo , Mizowaki Takashi 
Published: January 2022

AbstractPurposeTo evaluate the influence of respiratory motion on the robustness of radiomic features on four‐dimensional computed tomography (4DCT)‐based average intensity projection (AIP) images by employing an anthropomorphic chest phantom.MethodsThree spherical objects (φ30 mm), namely, acrylic (100 Hounsfield unit [HU], homogeneous), rubber (−140 HU, homogeneous), and cork (−630 HU, heterogeneous), were moved with motion amplitudes of 0, 1, 2.5, 4, 6, 8, and 10 mm in the phantom, and 4DCT scans were repeated at four different locations. Thereafter, the AIP images were generated considering the average of the 10 respiratory phases of the 4DCT images. Further, the targets were manually delineated on the AIP images in the lung window setting. A total of 851 radiomic features, including 107 unfiltered features and 744 wavelet filter‐based features, were extracted from the region of interest for each material. The feature robustness among the different target motion amplitude (ε) was evaluated by normalizing the feature variability of the target motion relative to the variability of data from 573 patients with early‐stage non‐small cell lung cancer. The features with absolute ε values ≤0.5 were considered highly robust to target motions.ResultsThe percentage of robust unfiltered and wavelet filter‐based features with a motion amplitude of 1 mm was greater than 83.2% and 93.4%, respectively; however, the percentage decreased by more than 24.3% and 17.6%, respectively, for motion amplitudes greater than 2.5 mm. The movement of cork had a small effect on the feature robustness compared to that of acrylic and rubber, regardless of the target motion amplitudes.ConclusionsOur phantom study demonstrated that target motion amplitudes ≤1 mm led to the robustness of radiomic features on the 4DCT‐based AIP images of thoracic regions. The frequency components and directions of the wavelet filters may be essential factors in 4DCT‐based radiomic analysis.
Yolk–Shell Antimony/Carbon: Scalable Synthesis and Structural Stability Study in Sodium Ion Batteries
Authors: Yang Xuming , Zhu Yuanmin , Wu Duojie , Li Menghao , He Yaqi , Huang Limin , Gu Meng 
Published: January 2022

AbstractAntimony with compelling features in capacity and sodiation voltage has not been literally considered for practical applications, due to the lack of scalable fabrication methods that can make antimony stable enough in cycling and more affordable than hard carbon. Herein, the synthesis of yolk–shell antimony/carbon composites from cheap source materials is introduced, which only entails common apparatuses and is not energy intensive. The reduction of antimony trioxide coated with polypyrrole (PPy) creates hollow space and gives rise to the construction of yolk–shell structures. The material cost is evaluated to be ≈$6.6 kg–1, which is much lower than the price of standard hard carbon. A sublimation–reduction mechanism is revealed by a heating experiment performed in using environmental transmission electron microscopy (TEM). From real‐time observation of the sodiation process, the feasibility of such structure designing is validated to counter expansion upon sodiation. The composite delivers a reversible capacity up to 612 mAh g–1 and exhibits excellent stability in deep cycling. The stability is correlated with the confinement of antimony inside the carbon shell. Through further characterization using cryogenic TEM, the generation of solid–electrolyte interphases on both the antimony and carbon is confirmed.
Tuning Mixed Electronic/Ionic Conductivity of 2D CdPS3 Nanosheets as an Anode Material by Synergistic Intercalation and Vacancy Engineering
Authors: Yang Xuebiao , Luo Yuhong , Li Jingde , Wang Hongqiang , Song Yingying , Li Jiao , Guo Zaiping 
Published: January 2022

AbstractMetal phosphorus trichalcogenides (MPTCs) are structurally adjustable 2D layered materials with unique electronic structures and high chemical diversity, implying the huge potential for energy storage application. In the typical electrochemical reaction process, rapid electron/ion conduction and abundant ion transport channels are the key parameters that influence the overall electrochemical performance of the electrode materials. Herein, 2D Cd1−xPS3Li2x nanosheets with enhanced mixed electronic/ionic conductivity are synthesized by the intercalation and vacancy strategy. The as‐prepared thin‐layered Cd1−xPS3Li2x electrode delivers high capacities of 1056 mAh g−1 at 0.2 A g−1 and 678 mAh g−1 at 8 A g−1, when used as anode in lithium‐ion batteries. The variation of electronic structure and spatial layered structure in Cd1−xPS3Li2x induced by the synergistic effect of lithium‐ion intercalation and Cd vacancies promote the dynamics of mixed electron/ion transport and offer more ion diffusion pathways, resulting in its excellent electrochemical performance. The strategy of mixed electron/ion conduction tuning for Cd1−xPS3Li2x can be extended to other MPTCs compounds to further develop their potential in the field of energy storage.
Discretization and Encapsulation of Palladium inside the Cavity of Crown Ether within the Interlayer of Layered Double Hydroxide for Enhanced Activity: A Case Study with Hydrogenation Reaction
Authors: Ravuru Shanmuk Srinivas , Jana Animesh , De Sirshendu 
Published: January 2022

AbstractThe activity of the noble metal‐based heterogeneous catalysts is limited by weak metal–support interactions, aggregation, and low surface to volume (S/V) ratio. The activity can be augmented in many ways. Among them, the discretization of the active sites and redistribution of electron density around the metal atom is an important one. In this work, these two phenomena are studied concerning a model reaction, hydrogenation of p‐nitrophenol (p‐NP). Herein, 1,4,7,10,13‐pentaoxacyclopentadecane ether is introduced in the basal space of layered double hydroxide (LDH) to encapsulate noble Pd0 atom inside the cavity of the crown molecule strategically. The modified LDH (Pda‐ECC‐L0.10@in situ CoAl LDH) augments the properties, like, high S/V ratio and nonaggregation of active sites by forming nonagglomerative discrete catalytic (DNSC) sites within the cavity of crown ether in the basal space. The developed catalyst exhibits higher turnover frequency demonstrating the improved activity due to the formed DNSC sites and redistributes electron density around the Pd atoms by LDH layers and crown molecules. Thus, the present material synthesis route can be considered as a stand‐alone method for preparation of the supported sub‐nanometer noble metal catalyst with higher activity and can be exploited for reactions where noble metal catalyst are used.
H3 (Hydrogel‐Based, High‐Sensitivity, Hybrid) Plasmonic Transducers for Biomolecular Interactions Monitoring
Authors: Miranda Bruno , Moretta Rosalba , Dardano Principia , Rea Ilaria , Forestiere Carlo , De Stefano Luca 
Published: January 2022

AbstractA hybrid plasmonic transducer made of a Poly‐(ethylene glycol) diacrylate (PEGDA) hydrogel and citrate gold nanoparticles detects the biotin‐streptavidin interaction at picomolar (× 10−12 m ) concentrations. The all‐solution fabrication strategy, herein proposed, is large‐scale, easily tunable, and low‐cost; nevertheless, this innovative device is highly reproducible and optically stable, and it can be used in dual‐optical mode. Indeed, both metal‐enhanced fluorescence and localized surface plasmon resonance signals can be exploited to quantify the biorecognition process in a 3D architecture. The large swelling capability of high molecular weight PEGDA is used to investigate the plasmon absorption variations resulting from the exposure to biological solutions containing high molecular weight molecules within the 3D network. The proposed transducer represents a low‐cost, flexible, and easy‐to‐use platform for sensing applications in biomedical or environmental diagnostics.
From Pain to Fear Recognition via Pavlovian Learning in an Organic–Inorganic Hybrid Neuromorphic Transistor
Authors: Wei Liubo , Jiang Jie , Wan Qing 
Published: January 2022

AbstractThe pain perception system is of great importance for the human body to perceive noxious stimuli in external environment and make an appropriate reaction. Therefore, the hardware realization of nociceptors using emerging solid‐state device is of great importance toward the next‐generation intelligent electronic devices. However, at present, the pain recognition with threshold regulation is still very lacking by using the solid‐state device. Herein, a novel pain‐perceptual device based on organic–inorganic hybrid MoS2 transistor is fabricated by using polyvinyl alcohol‐based electrolyte. The key characteristics of pain perception, such as threshold, sensitization, and desensitization behaviors, are realized in the organic–inorganic hybrid neuromorphic transistor based on the unique ion migration mechanism. Most importantly, the device exhibits a clear transition from pain to fear recognition through the Pavlovian training. These results provide a promising strategy to the next generation of bio‐inspired electronic devices, smart healthcare, cognitive electronics, etc.
A comprehensive neuromonitoring approach in a large animal model of cardiac arrest
Authors: Annoni Filippo , Peluso Lorenzo , Hirai Lucas Akira , Babini Giovanni , Khaldi Amina , Herpain Antoine , Pitisci Lorenzo , Ferlini Lorenzo , Garcia Bruno , Taccone Fabio Silvio , Creteur Jacques , Su Fuhong 
Published: January 2022

AbstractBackgroundAnoxic brain injuries represent the main determinant of poor outcome after cardiac arrest (CA). Large animal models have been described to investigate new treatments during CA and post‐resuscitation phase, but a detailed model that includes extensive neuromonitoring is lacking.MethodBefore an electrically‐induced 10‐minute CA and resuscitation, 46 adult pigs underwent neurosurgery for placement of a multifunctional probe (intracranial pressure or ICP, tissue oxygen tension or PbtO2 and cerebral temperature) and a bolt‐based technique for the placement and securing of a regional blood flow probe and two sEEG electrodes; two modified cerebral microdialysis (CMD) probes were also inserted in the frontal lobes and accidental misplacement was prevented using a perforated head support.Result42 animals underwent the CA procedure and 41 achieved the return of spontaneous circulation (ROSC). In 4 cases (8.6%) an adverse event took place during preparation, but only in two cases (4.3%) this was related to the neurosurgery. In 6 animals (13.3%) the minor complications that occurred resolved after probe repositioning.ConclusionHerein we provide a detailed comprehensive neuromonitoring approach in a large animal model of CA that might help future research.
Animal models in the study of Alzheimer's disease and Parkinson's disease: A historical perspective
Authors: Banerjee Rajashree , Rai Arushi , Iyer Shreyas M. , Narwal Sonia , Tare Meghana 
Published: January 2022

AbstractAlzheimer's disease and Parkinson's disease are two of the most prevalent and disabling neurodegenerative diseases globally. Both are proteinopathic conditions and while occasionally inherited, are largely sporadic in nature. Although the advances in our understanding of the two have been significant, they are far from complete and neither diagnosis nor the current practices in treatment and rehabilitation is adequately helpful. Animal models have historically found application as testing beds for novel therapeutics and continue to be valuable aids in pharmacological research. This review chronicles the development of those models in the context of Alzheimer's and Parkinson's disease, and highlights the shifting paradigms in studying two human‐specific conditions in non‐human organisms.
Generalized Gravitational Phase Transition in Novel 4D Einstein–Gauss–Bonnet Gravity
Authors: Samart Daris , Channuie Phongpichit 
Published: January 2022

AbstractIn this paper, the possible existence of a thermal phase transition from asymptotic anti‐de Sitter (AdS) to de Sitter (dS) geometries in vacuum in the context of the novel fourdimensional Einstein–Gauss–Bonnet (4D EGB) gravity is presented. The phase transition proceeds via a thermalon (the Euclidean section of a bubble thin shell) formation, having a black hole in the dS spacetime and a thermal AdS spacetime in the exterior, without introducing any matter field. From the analysis, it is found that, using regularized novel 4D EGB gravity, the gravitational phase transitions occur for all allowed values of the 4D EGB coupling. In the 4D EGB gravity, the existence of the above phase transition is over a narrow range of the 4D EGB coupling, with particular critical values. In contrast, in five‐dimensional (5D) EGB gravity, a 5D sector needs a wider range of its coupling for the existence of a thermalon, and there also exist critical values for the emergence of the above phase transition.
Structural evolution and properties of polyamide‐6/poly(ether block amide) films during the simultaneous biaxial stretching
Authors: Lin Xintu , Wu Yincai , Fan Shuhong , Chen Xi , Liu Yuejun , Liu Xiaochao , Zheng Wei 
Published: January 2022

AbstractThe purpose of this study was to investigate the structural evolution and properties of simultaneously biaxially stretched polyamide‐6/poly(ether block amide) copolymer (PA6/PEBA) films. The results showed the melting temperature of PA6 increased from 220.02°C to 225.56°C when the stretching ratios increased from 1 × 1 to 3.5 × 3.5, suggesting the occurrence of β → α crystal transformation. Meanwhile, the increase of stretching ratios increased the crystallinity of the films due to the molecular orientation, which could create a more tortuous path for the diffusion of oxygen molecules through the films. As a result, the oxygen barrier performance of the stretched PA6/PEBA film was increased after biaxial stretching. The morphological observation showed that spherical or slightly ellipsoidal PEBA particles were dispersed in the PA6 matrix. The thermal shrinkage of the stretched film increased as the stretching ratios increased, and no significant difference of the shrinkage between machine direction (MD) and transition direction (TD) was observed in the stretched films. It was also found that the tensile strength of the stretched films in MD and TD exhibited the highest value at a stretching ratio of 3.5 × 3.5, which was about 1.7 times and 2.1 times higher than that of the unstretched PA6/PEBA film, respectively.
Xenobiotic responses in insects
Authors: Gao Lujuan , Qiao Huanhuan , Wei Peng , Moussian Bernard , Wang Yiwen 
Published: January 2022

AbstractInsects have evolved a powerful detoxification system to protect themselves against environmental and anthropogenic xenobiotics including pesticides and nanoparticles. The resulting tolerance to insecticides is an immense problem in agriculture. In this study, we summarize advances in our understanding of insect xenobiotic responses: the detoxification strategies and the regulation mechanisms against xenobiotics including nanoparticles, the problem of response specificity and the potential usefulness of this study field for an elaborate pest management. In particular, we highlight that versatility of the detoxification system relies on the relatively unspecific recognition of a broad range of potential toxic substances that trigger either of various canonical xenobiotic responses signaling pathways, including CncC/Keap1, HR96, AHR/ARNT, GPCR, and MAPK/CREB. However, it has emerged that the actual response to an inducer may nevertheless be specific. There are two nonexclusive possibilities that may explain response specificity: (1) differential cross‐talk between the known pathways and (2) additional, yet unidentified regulators and pathways of detoxification. Hence, a deeper and broader understanding of the regulation mechanisms of xenobiotic response in insects in the future might facilitate the development and application of highly efficient and environmentally friendly pest control methods, allowing us to face the challenge of the world population growth.
Vibration suppression and fault‐tolerant control of an aerial refueling hose with multiple actuators
Authors: Song Congcong , Yan Xiaobao , Wang Qin , Liang Jinyuan , Han Zhiji , Liu Zhijie 
Published: January 2022

AbstractIn this paper, we propose an adaptive fault‐tolerant boundary vibration control approach for the flexible aerial refueling hose with variable length, variable speed, and multiple actuators. A distributed parameter system (DPS) is utilized to represent the dynamic behavior of the flexible refueling hose more precisely and accurately. Based on the established DPS model, we present a boundary vibration controller to suppress the vibration of the flexible refueling hose. In the controller, fault‐tolerant control with multiple actuators is considered to tackle the failure issues, and both multiplicative and additive failures are discussed in the fault situation. Then, by the Lyapunov direct method, we prove that the stability of the closed‐loop system is guaranteed under the proposed control approach. Numerical examples are presented to support the theoretical derivation.
Mimicking continuous capture chromatography for virus clearance using a single chromatography column model
Authors: Capito Florian , Flato Hendrik , Oeinck Verena , Dierl Stefan , Berg Annette 
Published: January 2022

AbstractContinuous chromatography is increasingly being used across the biotechnology industry due to its economic advantages. For adoption in commercial manufacturing, also models for virus clearance studies must be available. It is demonstrated how for a virus clearance study for a multispecific antibody, the continuous protein A capture chromatography process, being run on multiple interconnected columns, can be mimicked with only a single column. With this mimicking small‐scale model, resources and complexity can be minimized, when conducting virus clearance studies at a contract research organization (CRO) lab. Obtained log reduction values (LRV) for murine leukemia virus (xMuLV) and minute virus of mice (MVM) virus, used as model viruses, are comparable to batch protein A chromatography and results described by other groups. The feasibility of this mimicking small‐scale model helps to further reduce barriers to adoption when implementing continuous chromatography.
High production of jasmonic acid by Lasiodiplodia iranensis using solid‐state fermentation: Optimization and understanding
Authors: Shen Ziqiang , Zheng Pu , Li Ruiying , Sun Xingyun , Chen Pengcheng , Wu Dan 
Published: January 2022

AbstractBackgroundJasmonic acid (JA) is a plant hormone involved in regulating developmental and growth controls as well as photosynthesis. In addition, this hormone protects the plant against insects and has good applications in agriculture, the flavored industry and other fields. Filamentous fungus generally produces JA using liquid static culture. In the present study, a solid‐state fermentation (SSF) method is developed for high production of JA using Lasiodiplodia iranensis.Main methods and major resultsBy selecting the solid substrate and optimizing the initial water content, inoculum volume, loading volume and other culture conditions, the maximum JA yield reached 5306.38 mg kg–1 when fermented for 12 days in a petri dish containing a medium with crushed wheat as the solid substrate and 75% initial water content. The logistic and Luedeking–Piret models were used to characterize the relationship between microbial growth and product synthesis in the SSF process, and the maximum JA production is predicted to be 5263.23 mg kg–1, which is close to the experimental value. Liquid chromatography with tandem mass spectrometry (LC‐MS/MS) is used to examine the metabolic changes that develop during fermentation. The results indicate that JA biosynthesis occurs in the α‐linolenic acid metabolic pathway, of which 13(S)‐HpOTrE is a key intermediate metabolite and both 13(S)‐HOTrE and traumatic acid are byproducts of the branches of its synthesis.Conclusions and implicationsThe results of this study provide a method for obtaining high JA yields by SSF, and offer new insights for understanding the production of JA by fungal fermentation.
Sustainable management of electronic waste: Empirical evidences from a stakeholders' perspective
Authors: Alblooshi Badreya Gharib Khamis Mohammed , Ahmad Syed Zamberi , Hussain Matloub , Singh Sanjay Kumar 
Published: January 2022

AbstractWith rapid advancements in technology, the evolution and demand for electronic/electric devices have drastically increased. The exponential increase in the use of technology to fulfill the needs of the fast‐paced information era has led to electronic and electrical devices being discarded or disposed of at a faster rate than in the past. This phenomenon has resulted in e‐waste becoming the fastest‐growing form of solid waste. E‐waste is classified as hazardous waste and can be harmful to the environment and health if not disposed of responsibly. Therefore, alternatives, such as exporting, landfilling, and recycling (from different economic, social, technical, and environmental criteria), are of interest to minimize the disposal of this toxic waste form into landfill sites. The analytic hierarchy process approach was deployed to evaluate and prioritize alternatives for e‐waste processing systems in the United Arab Emirates context. The obtained results indicate that recycling has the highest priority among the studied alternatives in the e‐waste processing system. The low economic and environmental awareness of stakeholders with regard to e‐waste shows that e‐waste management system initiatives must be expedited to adhere to e‐waste best practices implemented nationally and internationally.
Structure‐Activity Relationships in Highly Active Platinum‐Tin MFI‐type Zeolite Catalysts for Propane Dehydrogenation
Authors: Lezcano‐González Inés , Cong Peixi , Campbell Emma , Panchal Monik , Agote‐Arán Miren , Celorrio Verónica , He Qian , Oord Ramon , Weckhuysen Bert M. , Beale Andrew M. 
Published: January 2022

AbstractPt/Sn‐containing MFI zeolites prepared by one‐pot hydrothermal methods are highly active and selective catalysts for propane dehydrogenation. An alternative preparation method is reported alongside an in‐depth characterization of Pt and Sn before and after reaction. Pt species dispersed on highly‐defective Silicalite‐1 show a significantly long catalytic lifetime with an improved coke resistance, but increased Pt−Sn alloying and the (eventual) build‐up of carbon leads to deactivation.
Isolation and Stabilization of the Metastable Form‐II Polymorph of Vanillin
Authors: Sundareswaran Supriya , Karuppannan Srinivasan 
Published: January 2022

AbstractIsolation and stabilization of the rare metastable polymorphic form‐II of vanillin was achieved by employing the template‐enhanced crystallization method through heterogeneous nucleation induced with Cu wire as the template surface. Irrespective of supersaturation, the solution induces the nucleation of the fine needle‐like form‐II polymorph on the surfaces of the Cu wire within a shorter induction period. This method has two main advantages: (i) It induces the nucleation of only the metastable form‐II polymorph of vanillin and (ii) stabilizes its steady growth without showing any solution‐mediated polymorphic phase transformation throughout. Thus, the harvested form‐II crystals stay for longer periods without showing any phase transformation at ambient conditions, with maximum stability.