bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative magnetic resonance spectroscopy study of GABA+ and glutamate referenced to creatine and phosphocreatine in the left dorsolateral prefrontal cortex of perimenopausal women and women of reproductive age
Authors: Tran Kim H. , Luki Jessica , Hanstock Sarah , Hanstock Christopher C. , Seres Peter , Aitchison Katherine , Shandro Tami , Le Melledo Jean-Michel 
Published: October 2022

ObjectiveThe perimenopause is associated with an increased risk of developing a major depressive (MD) episode. The biological changes occurring during perimenopause responsible for this increased risk of depression remain to be elucidated. Postmortem and magnetic resonance spectroscopy (MRS) studies have revealed decreased gamma-aminobutyric acid (GABA) and glutamate (Glu) levels in the dorsolateral prefrontal cortex (DLPFC) of MD patients. The objective of this study was to compare LDLPFC GABA+ and Glu ratios (referenced to creatine and phosphocreatine) in healthy reproductive-aged (RD) and perimenopausal (PM) women.Materials and methodsEighteen healthy PM and 20 RD women were included in the study. Our dependent variables, LDLPFC Glu and GABA+ ratios which include homocarnosine and macromolecules, were measured via MRS, using a 3 Tesla magnet. Absence of current or past psychiatric diagnosis was confirmed via a structured interview. RD participants were scanned during the early follicular phase of the menstrual cycle (MC). PM women were scanned outside of ovulatory cycles.ResultsMean LDLPFC GABA+ and Glu ratios were not statistically different between the PM group and RD group (PM mean = 0.10 ± 0.06, RD mean = 0.11 ± 0.04, t = –0.383, df = 36, d = −0.13, p = 0.70) (PM mean = 0.56 ± 0.06, RD mean = 0.57 ± 0.05, t = –0.794, df = 36, d = −0.26, p = 0.43), respectively. The perimenopause demarcates the end of the reproductive life. Unsurprisingly PM women were older than RD women (PM women: 48.8 ± 3.55 years, range 41–53 years old; RD women: 31.5 ± 9.66 years, range 18–47 years old) (p &lt; 0.001). This inherent entanglement of group and age is a limitation of our study.ConclusionContrary to our previous findings of decreased GABA+ and Glu in the medial prefrontal cortex in perimenopausal women, the perimenopause is not associated with decreased GABA+ or Glu ratios in the LDLPFC. This suggests that brain areas playing a role in MD display different sensitivity to the female hormones fluctuations associated with perimenopause.
Genitourinary cancers in the Arab world: A bibliometric study
Authors: Ibrahim Sarah , Farhat Theresa , Baalbaki Rim , Aoun Michael , Toumieh Georgio , Kaddoura Malak , Jaber Lubna , Taher Ali T. , Abdul-Sater Zahi 
Published: October 2022

BackgroundThe genitourinary cancer burden in the Arab region is rising at an increasing pace. The main objective of this study was to conduct a bibliometric analysis of scientific publications on genitourinary cancer to understand the growth, impact, trends, and flow of knowledge within GU cancer research in 22 Arab countries.MethodsThe Web of Science databases were searched for publications related to genitourinary cancer research in the 22 Arab countries from January 1, 2002, till December 31, 2021. The scientific research was evaluated based on productivity (number of published documents, authorships), impact (citation counts and journals impact factor), collaborations, and areas of interest for published papers.ResultsA total of 3,129 papers met the inclusion criteria in this research. After adjusting for the population power, Qatar (53.57) and Lebanon (46.83), Saudi Arabia (46.21), Jordan (41.58), and Tunisia (40.72) had the highest research productivity. The number of articles and average citations per year was generally increasing. Most Arab corresponding authors were from Egypt, Saudi Arabia, and Tunisia, and most Arab first authors were male researchers, highlighting gender inequality in genitourinary cancer research. Both regional and international collaborations are weak between authors in the field.ConclusionThis bibliometric research provided a framework for visual and quantitative research productivity on GU can in the Arab world. Research output is low in some countries, which can be improved by investing in more international and national collaborative research projects in the field of GU cancer.
Orthopedic therapeutic surgery for bone metastasis of liver cancer: Clinical efficacy and prognostic factors
Authors: Lian Qiujian , Liu Chang , Chen Fengmei , Wang Bingxuan , Wang Miao , Qiao Suchi , Guan Zhengmao , Jiang Shuai , Wang Zhiwei 
Published: October 2022

ObjectivesIn this study, the objectives were to investigate the clinical efficacy of orthopedic therapeutic surgery (OTS) in patients with bone metastasis of liver cancer and explore the prognostic factors.MethodsThe electronic medical records of patients with bone metastasis of liver cancer in the Third Affiliated Hospital of Naval Medical University from September 2016 to August 2021 were retrospectively collected. A total of 53 patients were included. Patients were assigned to the OTS (n = 35) or the control group (n = 18) based on receiving orthopedic therapeutic surgery or conservative treatment. The pre/posttreatment Karnofsky Performance Status scale (KPS) and numeric rating scale (NRS) scores were compared. Univariate and multivariate Cox regression analyses were used to explore the prognostic factors affecting survival after bone metastasis. Logistic regression analyses were adopted to discover potential factors that contributed to greater KPS score improvement.ResultsThe axial bone accounted for 69.8% of all bone metastases. The proportion of multiple bone metastases was 52.8%. After surgery, the median KPS score of the OTS group increased from 60 to 80 (p &lt; 0.001), and the median increase in the OTS group was higher than that of the control group (p = 0.033). The median NRS score of the OTS group declined from 6 to 2 after surgery (p &lt; 0.001), and the median decline in the OTS group was higher (p = 0.001). The median survival was 10 months in the OTS group vs. 6 months in the control group (p &lt; 0.001). Higher pretreatment KPS scores, undergoing liver primary lesion surgery, and undergoing orthopedic therapeutic surgery were protective factors of survival. Undergoing orthopedic therapeutic surgery greatly improved the KPS score.ConclusionsOrthopedic therapeutic surgery for bone metastasis of liver cancer provides benefits to the quality of life. Patients who have their primary liver lesions removed, undergo orthopedic therapeutic surgery, and have a better physical condition before treatment tend to have longer survival.
A Polarization-Insensitive Broadband Terahertz Absorber Using Patterned Graphene
Authors: Fu Maixia , Wang Jinyi , Guo Shaoshuai , Wang Zhaoying , Yang Pengxu , Niu Yingying 
Published: October 2022

A polarization-insensitive broadband terahertz absorber with a sandwich structure of metal–dielectric-graphene is designed and simulated. The graphene is patterned as an array of graphene square blocks with circular apertures. The results of the simulations and theoretical analysis show that the absorption exceeds 99% from 0.93 to 1.65 THz while 90% from 0.80 to 1.87 THz, and a broad relative bandwidth of 80.2% is achieved. The absorption performance is passively enhanced by altering physical dimensions of the graphene pattern and actively adjusted by changing the chemical potential of graphene. When the chemical potential increases from 0.1 eV to 0.7 eV, the corresponding terahertz absorption increases from 59.1% to 99%. The mechanism of absorption is disclosed by analyzing the impedance matching theory and distribution of electric-field intensity. In addition, different polarization modes and incident angles are also studied. The proposed absorber has the superiorities of broad relative bandwidth, high absorption rate, polarization insensitivity, and a wide incident angle, which offers some potential applications in the field of terahertz technology such as imaging, detection, and cloaking.
THE PHENOMENOLOGY AND TYPOLOGY OF BIOGENIC DEPRIVATIONS
Authors: Kobylchenko V. , Omelchenko I. 
Published: October 2022

The article examines the problem of deprivation analysed as a multifactorial psychological phenomenon that has a significant negative impact on children's personal development. The nature of deprivation is determined depending on the factors that generate it, namely, biogenic, sociogenic and psychogenic.
The phenomenology of biogenic deprivation is revealed, its features and consequences for children's psychosocial development are characterized.
We have determined that if a certain organic violation exists, there are always leading and concomitant types of deprivation. Accordingly, each violation basically causes a certain leading deprivation; and this fact allows us to derive a certain typology of biogenic deprivation.
Visual deprivation occurs at visual impairments, auditory deprivation does at hearing impairments, mental deprivation appears at intellectual development impairments (feeble minding), cognitive impairments does at cognitive development impairments (mental retardation), speech (communicative) one does at speech disorders, motor one does at musculoskeletal system disorders, deprivation of identity (social one) does at autistic spectrum disorders.
All types of deprivation have some common manifestations, namely: increased anxiety, decreased vital activity, frequent mood swings, unmotivated aggression, etc.
Perancangan Sistem Informasi Akuntansi Harga Pokok Produksi Berdasarkan Job Order Costing
Authors: Azahra Sayyidah Nabila , Supriyati S 
Published: October 2022

Transaksi digital yang semakin berkembang membuat penggunaan teknologi informasi dalam berbagai bisnis perusahaan semakin dibutuhkan. Pada perusahaan manufaktur terdapat perhitungan harga pokok produksi (HPP) yang merupakan bagian terpenting dalam menghitung biaya yang dikeluarkan saat proses produksi. Namun, permasalahan human error atau kesalahan manusia sering muncul saat perhitungan HPP masih dilakukan secara manual salah satunya adalah di perusahaan liwet Asep stroberi. Tujuan penelitian ini adalah untuk merancang sistem informasi akuntansi harga pokok produksi pada liwet Asep stroberi yang saat ini penentuan harga pokok produksinya belum sesuai dengan standar akuntansi. Dengan ketidakstabilan harga pokok produksi dapat mempengaruhi kenaikan biaya produksi yang mengakibatkan laba atau rugi perusahaan sehingga tidak dapat terpantau oleh manajer, selain itu pencatatan akuntansi belum terkomputerisasi sehingga dapat menghambat waktu pengerjaan laporan harga pokok produksi. Sistem informasi yang dirancang oleh penulis menggunakan bahasa pemrograman Hypertext Preprocessor atau PHP dan database postgreSQL. Model perancangan sistem informasi yang digunakan adalah diagram konteks, flowchart dan model pengembangan sistem menggunakan model Software Development Life Cycle (SDLC) air terjun (waterfall). Tujuan dari perancangan sistem ini adalah membantu dalam proses pencatatan, perhitungan dan laporan harga pokok produksi secara efektif dan efisien. Hasil dari penelitian ini adalah rancangan sistem informasi akuntansi perhitungan harga pokok produksi berdasarkan job order costing.
Articulação entre Práticas Integrativas e Promoção da Saúde: ações coletivas com acupuntura na Estratégia Saúde da Família
Authors: Oliveira Andréa Mauricio de Gouveia , Pezzato Luciane Maria , Mendes Rosilda 
Published: October 2022

As Práticas Integrativas e Complementares em Saúde(PICS) são práticas terapêuticas reconhecidas pela Organização Mundial de Saúde e englobam várias práticas corporais e comportamentais, sendo uma delas a acupuntura. Esta pesquisa teve como objetivo refletir uma experiência inovadora que articulou uma prática de acupuntura com a promoção da saúde em uma Unidade de Saúde da Família. Foi realizado um estudo descritivo e analítico, de natureza qualitativa, que utilizou rodas de conversas e registros em diário de campo como estratégias para produção de dados. Este estudo possibilitou uma ampliação no acolhimento das demandas dos usuários, com estreitamento de vínculo entre a equipe de saúde e a comunidade, contribuindo para a desmedicalização do cuidado. Percebemos a ampliação da oferta da clínica, o aumento do conhecimento das PICS, com incentivo à desmedicalização, autocuidado, participação de atividades em grupo, troca de saberes e inserção de estratégias capazes de colaborar com o processo de reconstrução de modos de viver a vida de pessoas que buscam o serviço de saúde.
Abordagem de organização facilitada para otimização de testes rápidos de detecção de infecções sexualmente transmissíveis: um relato de experiência
Authors: Ferreira Mara Gabriela Brasileiro de Lucena , Santos Romário , Santos Barbosa Tamires Correia dos , Da Silva Luís Roberto , Meneses Macedo Laiz Mara , Lucena Madhalena Lindha Ferreira de , Correia Divanise Suruagy , Monte Mello Taveira Maria das Graças 
Published: October 2022

Ao confrontar a elevação dos números de casos de infecções sexualmente transmissíveis, em especial a AIDS, a sífilis e as hepatites virais do tipo B e C; constatamos a necessidade de uma testagem mais expressiva da população por meio da facilitação do acesso aos insumos e demais materiais necessários para os procedimentos, visando à otimização do tempo dos usuários do serviço público de saúde e gerando uma maior adesão aos mecanismos de testagem. A facilitação do acesso aos materiais para testagem gerou uma diferença de seis vezes no número de testes quando comparados o primeiro mês do experimento e o último. A maior modificação, no entanto, não se concentrou no aparecimento da bancada com seu protocolo guia, mas sim na participação conjunta de todos os profissionais da equipe de saúde, buscando compreender e se envolver nos processos de testagem, de modo que todos estivessem aptos a realizar adequadamente os procedimentos assim que se fizesse necessário. Evidenciou-se o potencial beneficiador que a facilitação do acesso aos testes rápidos, com a devida capacitação conjunta da equipe disponível, produz efeitos notórios no rastreio e no diagnóstico precoce de infecções sexualmente transmissíveis de elevadas prevalências.
Utilização de atendimentos no serviço de Atenção Básica em um município do Espírito Santo segundo perfil sociodemográfico e de condições de saúde
Authors: Barros Camila Altoé , Silva Kátia Silveira da , Ramos Eloane Gonçalves 
Published: October 2022

A Atenção Básica é a principal porta de entrada do Sistema Único de Saúde. O acesso efetivo a esse serviço pode ser avaliado pela utilização de atendimentos, e não apenas pela disponibilidade. O conhecimento do perfil populacional permite identificar grupos vulneráveis à não utilização, assim como conhecer as morbidades mais prevalentes para promover melhor organização da oferta e utilização do serviço. Este trabalho trata-se de um estudo transversal, cujas fontes de dados foram registros das fichas do e-SUS de 8.390 indivíduos, cadastrados numa Unidade de Saúde da Família (USF). Foi analisada a prevalência de utilização de atendimentos na USF, nos quais se incluíram consultas médicas e de enfermagem. Foram comparados os perfis sociodemográfico e de morbidade referida dos utilizadores e não utilizadores da USF em 2019. O percentual de utilização de consultas foi de 50,1% dos cadastrados, sendo a média de 2,3 consultas por habitante ao ano. A maioria dos utilizadores fez até cinco consultas ao ano, porém aproximadamente um terço das consultas se referiram aos hiperutilizadores. Ser do sexo feminino, ser pardo ou negro, ter baixa escolaridade, idade mais avançada e não possuir plano de saúde privado foram condições associadas à maior utilização de consulta.
Potensi Infusa Daun Tradescantia spathaceae Sebagai Tabir Surya pada Sediaan Gel Menggunakan Metode Spektrofotometri UV-Vis
Authors: Rubiyanti Rani , Aji Nur 
Published: October 2022

Daun nanas kerang (Tradescantia spathaceae) memiliki pigmen ungu dihasilkan dari antosianin. Senyawa ini diduga memiliki aktivitas tabir surya. Tujuan dari penelitian ini untuk menguji potensi tabir surya baik infusa maupun sediaan gel daun nanas kerang secara in vitro menggunakan spektrofotometri UV-Vis serta mengetahui stabilitasnya. Formula gel menggunakan infusa daun nanas kerang dengan konsentrasi 12,5%; 25% dan 50%. Parameter yang diamati pada penelitian ini dalah organoleptik, homogenitas, pH, uji daya sebar, viskositas, nilai Sun Protection Factor (SPF) dan uji waktu simpan. Formulasi gel infusa nanas kerang dengan tiga variasi konsentrasi menghasilkan karakteristik gel yang berbeda. Semakin besar jumlah infusa maka viskositas semakin berkurang dan berbanding terbalik dengan nilai daya sebar. Sediaan memiliki pH yang baik dan sesuai dengan pH kulit yaitu pada rentang 5,87-7,00. Infusa nanas kerang memiliki nilai SPF berturut-turut: 3,64; 6,83 dan 12,73. Sedangkan gel infusa nanas kerang memiliki SPF berturut turut yaitu: 7,48; 9,55 dan 14,06. Berdasarkan penelitian dapat disimpulkan, infusa nanas kerang dapat dibuat dalam sediaan gel. Baik infusa maupun sediaan gel infusa nanas kerang pada konsentrasi 12,5% sampai dengan 50% memiliki daya proteksi kategori rendah dan gel infusa nanas kerang tidak stabil selama penyimpanan.
Uji Toksisitas Subkronis Ekstrak Etanol Daun Pucuk Merah (Syzygium Myrtifolium Walp.) Terhadap Fungsi Hati Dan Ginjal
Authors: Hasti Syilfia , Rusnedy Rahmayati , Musdalifah Musdalifah , Asnila Asnila , Renita Lisa , Santi Ferelina , Anggraini Shella , Sinata Novia 
Published: October 2022

Untuk pengembangan obat bahan alam dari ekstrak etanol daun pucuk merah (Syzygium myrtifolium Walp) harus dilakukan serangkaian uji keamanan secara praklinik agar diketahui keamanannya jika digunakan jangka panjang. Uji toksisitas subkronis ekstrak etanol daun pucuk merah dilakukan dengan menilai fungsi ginjal dan hati hewan uji setelah diberikan sediaan uji yang diberikan selama 60 hari, berupa pemeriksaan biokimia darah menggunakan alat Mindray®BA-88A dan pemeriksaan histologi organ ginjal dan hati. Hasil penelitian menunjukkan bahwa pemberian ekstrak etanol daun pucuk merah dosis 300, 600 dan 900 mg/kgBB tidak mempengaruhi aktivitas SGOT, SGPT, kadar kreatinin serum secara signifikan (p>0,05). Secara mikroskopis terhadap persentase kerusakan glomerulus ginjal kanan dan ginjal kiri pada dosis 600 dan 900 mg/kgBB terdapat perbedaan yang signifikan terhadap kelompok kontrol (p<0,05). Untuk pemeriksaan mikroskopis secara kualitatif yakni pengamatan sinusoid dan sel hepatosit pada tiap pemberian tingkatan dosis mengalami perubahan abnormal. Sedangkan pemeriksaan mikroskopis secara kuantitatif pada dosis 600 dan 900 mg/kgBB menyebabkan kenaikan persentase kerusakan vena sentralis (p<0,05). Dari penelitian dapat disimpulkan pemberian ekstrak etanol daun pucuk merah pada mencit putih aman terhadap fungsi hati dan ginjal pada dosis 300 mg/kgBB tetapi kelompok dosis 600 dan 900 mg/kgBB memberikan efek toksik terhadap organ ginjal dan hati bila dibandingkan dengan kelompok kontrol.
Comparison of Side Effects Propofol-Fentanyl and Propofol-Fentanyl-Midazolam in Central Medical Installation Hospital X Bogor
Authors: Nurafni Silvi , Desminingrum Tri , Mainanda Evida 
Published: October 2022

Propofol is one of the most commonly used intravenous drugs employed to induce and maintain general anesthesia. The effective induction dose of propofol is 1.0-2.5 mg/kg IV caused hemodynamic instability significant as hypotension. Stability hemodynamic in used propofol can optimized with midazolam-fentanyl. The aims of this study was to determine the comparison of side effects propofol-fentanyl and propofol-fentanyl-midazolam in patient undergoing elective surgery with parameter of blood pressure, pulse, respiratory rate (RR). This study was a observational with prospective method in 60 patients undergoing elective surgery with physical status ASA I-II conducted in the period of April to July 2019. The result showed the induction anesthesia used of propofol-fentanyl caused decreased on systolic blood pressure 17,2±3 mmHg, diastolic blood pressure 5,3±1,6 mmHg, pulse 3,9±1,5 beats/minute, and RR 1,4±0,01 breaths/minute. The induction anesthesia used of propofol-fentanyl-midazolam caused decreased on systolic blood pressure 11,8±0,4 mmHg, diastolic blood preasure 4,2±0,4 mmHg, pulse value 5,0±0,9 beats/minute, and RR 2,8±0,9 breaths/minute. Side effects in the form of blood pressure, pulse and respiratory rate from the administration of the combination of propofol-fentanyl and propofol-fentanyl-midazolam were not significantly different.
Aktivitas Achyranthes Aspera Linn. dalam Menurunkan Kadar Kolesterol dan Glukosa Darah Hewan Uji Resistensi Insulin
Authors: Viviandhari Daniek , Maharadingga Maharadingga , Zahria Farah , Hardiyanti Putri 
Published: October 2022

Faktor penyebab terbanyak pada pasien diabetes melitus tipe 2 adalah resistensi insulin. Jarong diketahui sebagai tanaman obat yang berdasarkan penelitian sebelumnya terbukti menurunkan kadar kolesterol total, trigliserida, dan glukosa darah, namun belum diketahui dosis efektifnya pada tikus resistensi insulin. Sehingga perlu penelitian lanjutan untuk menentukan efek dan dosis. Tujuan riset ini yaitu menilai aktivitas ekstrak etanol 70% daun jarong dalam menurunkan kadar kolesterol total, trigliserida, glukosa darah, serta Tes Toleransi Glukosa Oral (TTGO) tikus resistensi insulin. Sebanyak 28 ekor hewan uji (4 ekor tiap kelompok) dibagi dalam 7 macam perlakuan, terdiri dari kontrol normal (tidak diinduksi), kelompok negatif (suspensi Na CMC 0,5%), kelompok positif 1 (fenofibrat), kelompok positif 2 (metformin HCl), kelompok ekstrak dosis 250, 500, dan 750 mg/kgBB selama perlakuan 14 hari. Induksi resistensi insulin menggunakan streptozotocin. Kadar trigliserida, kolesterol total, glukosa darah, dan TTGO diukur menggunakan spektrofotometer klinikal. Analisis data dengan oneway ANOVA kemudian uji Tukey. Data menunjukkan ekstrak daun jarong dosis 750 mg/kgBB mampu menurunkan kadar kolesterol total, trigliserida, glukosa darah, dan TTGO dengan persentase penurunan berturut-turut 48,83%, 48,95%, dan 61,31%, serta pada TTGO nilai AUC terkecil yaitu 23.991 mg/dL per menit pada tikus resistensi insulin.
Modeling Reconfigurable Intelligent Surfaces-aided Directional Communications for Multicast Services
Authors: Chukhno Olga , Chukhno Nadezda , Pizzi Sara , Molinaro Antonella , Iera Antonio , Araniti Giuseppe 
Published: October 2022

<p>According to the 6G vision, the evolution of wireless communication systems will soon lead to the possibility of supporting Tbps communications, as well as satisfying, individually or jointly, a plethora of other very stringent quality requirements related to latency, bitrate, and reliability. The achievement of these goals will naturally raise many research issues within radio communications. In this context, a promising 6G wireless communications enabler is the reconfigurable intelligent surface (RIS) hardware architecture, which has already been recognized as a game-changing way to turn any naturally passive wireless communication setting into an active one. This paper investigates RIS-aided multicast 6G communications by first modeling the system delay as a first-come-first-served (FCFS) M/D/1 queue and analyzing the behavior under different blockage conditions. Then the study of multi-beam operation scenarios, covering multicast and RIS-aided multicast communications, is conducted by leveraging an M/D/c queue model. Achieved results show that large-size RISs outperform even slightly obstructed direct BS-to-user paths. In contrast, RISs of smaller sizes require the design of sophisticated power control and sharing mechanisms to achieve better performance.</p>