bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individual experience influences reconstruction of division of labour under colony disturbance in a queenless ant species
Authors: Tanaka Yasunari , Hojo Masaru K , Shimoji Hiroyuki 
Published: May 2022

Abstract
BackgroundDivision of labour (DOL) is ubiquitous across biological hierarchies. In eusocial insects, DOL is often characterized by age-related task allocation, but workers can flexibly change their tasks, allowing for DOL reconstruction in fluctuating environments. Behavioural change driven by individual experience is regarded as a key to understanding this task flexibility. However, experimental evidence for the influence of individual experience is remains sparse. Here we tested the effect of individual experience on task choice in the queenless ponerine ant, Diacamma cf. indicum from Japan.ResultsWe confirmed that both nurses and foragers shifted to vacant tasks when the colony composition was biased to one or the other. We also found that nurses which are induced to forage readily revert to nursing when reintroduced into balanced colonies. In contrast, foragers which are induced to revert to nursing very rarely return to a foraging role, even 19 days post reintroduction to their original colony. ConclusionsTaken together, our results suggest that individual experience decreases the response threshold of original foragers, as they continue to be specialist nurses in a disturbed colony. However, original nurses do not appear strongly affected by having forager experience and revert to being nurses. Therefore, while individual experience does have an effect, other factors, such as reproductive ability, are clearly required to understand DOL maintenance in fluctuating environments.
Analysis and Validation of TMED3 correlates with poor prognosis and tumor immune infiltration of glioma
Authors: liao gang , Zhang Meimei , wang chunliang 
Published: May 2022

Abstract
Background:Glioma is the most common primary intracranial tumor. It is notorious for its high degree of malignancy, strong invasion, and poor prognosis. The transmembrane emp24 trafficking protein 3 (TMED3) belongs to the TMED family, which is responsible for intracellular protein transport and innate immune signal transmission. More and more evidence shows that TMED3 plays a key role in the tumor progression of human cancer. However, the role and potential molecular mechanism of TMED3 in glioma have not been clarified. Methods: TMED3 expression levels, clinical data, survival prognosis, prediction of upstream miRNA, and immune-related analyses were all analyzed utilizing relevant databases. Finally, a molecular cell experiment confirmed TMED3 expression in glioma. Results: We discovered that TMED3 is overexpressed in most tumors, including gliomas, and is associated with tumor staging and prognosis. Subsequently, a combination of a series of bioinformatics analyses, including correlation and survival analyses, identified miR-1296-5p as the most potent upstream miRNA of TMED3 in gliomas.Additionally, we analyzed the relationship between TMED3 level and tumor immune cell infiltration and immune checkpoint expression.Conclusion TMED3 is highly expressed in gliomas and is associated with tumor staging and affects the prognosis of patients. Therefore, the TMED3 gene may be a potential immunotherapy target and prognostic marker for gliomas.
Landscape of N(4)- acetylcytidine modified genes in triple-negative breast cancer Revealing the potential markers of N(4)-acetylcytidine through acRIP-seq in triple-negative breast cancer
Authors: Zhang Xingda , Zeng Jiaqi , Wang Jianyu , Yang Zihan , Gao Song , Liu Honghao , Li Guozheng , Zhang Xin , Gu Yue , Pang Da 
Published: May 2022

Abstract
Background: Triple-negative breast cancer (TNBC) still lacks effective treatments, and understanding the causes of its tumorigenesis and tumor progression is helpful for prognostic evaluation. N(4)-acetylcytidine (ac4C), an epigenetic modification of RNA, whose regulatory mechanism is still unclear in TNBC tumors may provide a new perspective for understanding the development of TNBC.Methods: Two pairs of TNBC patient tissues were sequenced at the genome level using acRIP-seq technology, and differential ac4C genes were identified by Robust Rank Aggregation (RRA). Then, by integrating genome-wide lncRNA expression profiles in TCGA, we constructed a co-expression network containing 180 ac4C genes and mined 1080 lncRNA gene relationship pairs. And use cox regression analysis to screen genes associated with prognosis. Additionally, drug sensitivity was predicted using a drug target network of differential ac4C genes.Results: We screened a total of 180 differential ac4c genes, of which 6 genes were significantly associated with prognosis. In addition, we screened out three lncRNAs interacting with prognostic risk genes, and the corresponding interaction pairs were "LINC01614-COL3A1", "OIP5-AS1-USP8" and "RP5-908M14.9-TRIR". Significant ac4C genes COL3A, USP8 and TRIR1 were accurately predicted with the sensitivity of Doxorubicin and Paclitaxel, the main chemotherapy drugs in TNBC. Conclusions: This study suggests that RNA ac4C acetylation may be a potential marker of prognosis and drug sensitivity/target through the involvement of lncRNA. These results will be used as a guide for experiments.
Using Serum Cystatin C to Predict Acute Kidney Injury following Infant Cardiac Surgery
Authors: Abadeer Maher , Swartz Michael F. , Martin Susan D. , Kent Alison L. , Schwartz George J. , Brophy Patrick , Alfieris George M. , Cholette Jill M. , Groves Angela M. 
Published: May 2022

Abstract
Background: Acute kidney injury (AKI) following cardiopulmonary bypass (CPB) is associated with increased morbidity and mortality. Serum Cystatin C (CysC) is a novel biomarker synthesized by all nucleated cells that may act as an early indicator of AKI following infant CPB. Methods: Prospective observational study of infants (< 1 year) requiring CPB during cardiac surgery. CysC was measured at baseline and 12, 24, 48, and 72 hours following CPB initiation. Each post-op percent difference in CysC (e.g. %CysC12hr) from baseline was calculated. Clinical variables along with urine output (UOP) and serum creatinine (SCr) were followed. Subjects were divided into two groups: AKI and non-AKI based upon the Kidney Disease Improving Global Outcomes (KDIGO) classification. Results: AKI occurred in 41.9% (18) of the 43 infants enrolled. Patient demographics and baseline CysC levels were similar between groups. CysC levels were 0.97 ± 0.28 mg/L over the study period, and directly correlated with SCr (R = 0.71, p < 0.0001). Although absolute CysC levels were not significant between groups, the %CysC12hr was significantly greater in the AKI group (AKI: -16%±22% vs. Non-AKI -28%±9% mg/L; p=0.003). However, multivariate analysis demonstrated that a lower UOP (Odds Ratio:0.298; 95% CI:0.073, 0.850; p=0.02) but not %CysC12hr was independently associated with AKI. Conclusions: Despite a significant difference in the %CysC12hr, only UOP was independently associated with AKI. Larger studies of a more homogenous population are needed to understand these results and to explore the variability in this biomarker seen across institutions.
Antibacterial Activity of Herbal Plantago major and Plantago lanceolata extracts on Pseudomonas aeruginosa with emphasis on Exotoxin A gene expression and Bioinformatics approach
Authors: ABBASI Asieh , MADDAH Seyyedeh Mahdokht , ALI Dhuha SAEED , KAMALINEJAD Mohammad 
Published: May 2022

Abstract
Pseudomonas aeruginosa contamination could be a significant cause of dismalness in burns patients. To detect the antibacterial potentials of Plantago lanceolata and Plantago major extracts against Pseudomonas aeruginosa and assess their potential to control the toxA gene expression with a bioinformatics approach. The antibacterial sensitivity test, MIC, and MBC were performed. The expression value of toxA was evaluated using a qPCR assay. A molecular dynamics simulation and toxicity risk assessment were done. Results indicated a remarkable antibacterial activity of the crude extracts compared to other fractionated plant extracts. The mean zone of inhibition ranges up to 16mm (P. major, 1000 mg/mL) and 20 mm (P. lanceolata, 1000 mg/ml) against P. aeruginosa. Water extract showed the inhibition zone, while the Petroleum ether and chloroform did not show any inhibition activity. Tox-A gene expression value had been significantly (P < 0.05) decreased at the most concentrations of both plants. Molecular docking and toxicity risk assessment revealed that luteolin ligand (LD50: 5000 mg/kg) with a lower toxicity dose could be a potential drug for treating P. aeruginosa infections. Findings revealed that the crude extract of both plants has possible antibacterial activity and could be considered against P. aeruginosa pathogenicity. Furthermore, Luteolin might be a helpful drug for treating P. aeruginosa infections.
Memory impairment associated with Papez circuit lesions in patients with severe traumatic brain injury assessed by diffuse tensor imaging and volumetric MRI analysis.
Authors: Simeone Pierre , Auzias Guillaume , Lesimple Blandine , Feghaly Elissa , Lefèvre Julien , Takerkart Sylvain , Coulon Olivier , Torkomian Gregory , Battisti Valentine , Jacquens Alice , Couret David , Naccache Lionel , Boussen Salah , Bayen Eleonore , Bruder Nicolas , Perlbarg Vincent , Puybasset Louis , Velly Lionel 
Published: May 2022

Abstract
IMPORTANCE: Papez circuit is composed of deep structures of the limbic system which supports episodic memory. Biomechanical modelling suggests that this circuit is particularly exposed to shear forces during traumatic brain injury (TBI). Recent studies showed the relevance of MRIderived measures for improving diagnosis and adapt care of TBI patients. However, the relationship between MRI measures in this specific circuit and memory disorders resulting from TBI remains poorly documented.OBJECTIVE: To relate MRI measurements of the Papez circuit to episodic memory impairment (EMI) in TBI patients, and to assess the relevance of MRI to diagnose EMI consecutive to TBI. DESIGN, SETTING AND PARTICIPANTS: This is a prospective observational study with severe TBI patients enrolled (2006-2012) who did receive neuropsychological assessment and multiparametric brain MRI at distance from the trauma. Patients were classified by neuropsychologist into two groups: those showing an episodic memory impairment (EMI+) and those without impairment (EMI-). We defined an anatomical delineation of the Papez circuit and its sub regions. We extracted MRI measurements in each of these regions and compared statistically between EMI+ and EMI- patients. The same methodology was applied to a control group of 50 healthy controls (HC) to compare with normative values.MAIN OUTCOMES AND MEASURES: Normalized fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD) were derived from diffusion tensor imaging (DTI) data. The volume of the Papez circuit was extracted from anatomical MRI.RESULTS: Over the study period (2009-2016), 100 patients received an MRI and a neuropsychological assessment 63±22 months after the initial TBI. Patients EMI+ had significantly lower FA and higher MD, RD and AD values than the EMI- and HC in the Papez circuit. Volume measurements showed no difference between EMI+ and EMI-. We also reported abnormalities pattern across sub regions of this circuit between EMI+ and EMI-. The potential of MRI measures in Papez circuit to help diagnosis of EMI in severe TBI patients was confirmed by a multivariate model combining clinical data at baseline and MRI features.CONCLUSIONS AND RELEVANCE: Our study shows a high incidence of damage to the Papez circuit following severe TBI associated with episodic memory impairments. MRI measures of the Papez circuit constitute relevant information for the diagnosis of EMI in severe TBI patients.
The Nonlinear Analysis in p-Vector Spaces by Applying Best Approximation Method
Authors: YUAN George Xianzhi 
Published: May 2022

Abstract

It is known that the class of p-vector spaces (0 < p ≤ 1) is an important generalization of usual norm spaces with rich topological and geometrical structure, but the most tools and general principles with nature in nonlinearity have not been developed yet, the goal of this paper is to develop some useful tools in nonlinear analysis by applying the best approximation approach for the classes of semiclosed 1-set contractive set-valued mappings in p-vector spaces. In particular, we first develop the general fixed point theorems of condensing mappings which provide answer to Schauder conjecture in 1930’s in the affirmative way under the setting of p-vector spaces by taking p = 1 for a p-vector space being a topological vector space. Then one best approximation result for upper semi-continuous and 1-set contractive set-valued is established, which is used as a useful tool to establish fixed points of non-self set-valued mappings with either inward or outward set conditions. Finally, we develop fixed points and related principle of nonlinear alterative for the classes of semiclosed set-valued mappings including nonexpansive set-valued mappings as special cases under uniformly convex Banach spaces, or locally convex topological spaces with Opial condition. The results in this paper under the category of nonlinear analysis not only include the corresponding results in the existing literature as special cases, but also expected to be useful tools for the study of nonlinear problems arising from theory to practice under the general framework of p-vector spaces for 0 < p ≤ 1.
APPLIED PUBLIC SECTOR ACCOUNTING FOR BROADBAND INFRASTRUCTURE DEVELOPMENT WITH PUBLIC PRIVATE PARTNERSHIP SCHEME: A LITERATURE REVIEW
Authors: Steelyana Evi 
Published: May 2022

Governments all around the world are increasingly focusing on Public-Private-Partnership (PPP) schemes to develop broadband infrastructure. Private sector participation in the development and funding of public infrastructure has had a substantial impact on the delivery of public services. In PPP Broadband Infrastructure, there has been no attempt to integrate the literatures in order to present a holistic view. To expand our knowledge of PPPs in Public Sector Accounting Discipline, the author conducted a systematic literature review of articles published in international journals and to analyze the contribution of it to the body of knowledge. By using a qualitative method, the objective of the study is to find the major theme of public sector accounting literatures based on research of PPP in Broadband Infrastructure for the past 20 years (2000-2020) from the qualified international journals. The study also aims to find contribution of the major theme on infrastructure development and the direction of the future research that need to be addressed. The study found that UK is the country which has been publishing journals on PPP with high intensity of publication. Another findings are the literatures were published in high quality journal with scopus indexed is 60% in Q1 and followed 25% in Q2 and 15% in Q3. The main findings of this study identified four main topics in this discipline which are Public Policy Strategy has become the major theme in the field of research and become the first rank, followed by another themes which are PPP Implementation, PPP Framework and Value of Money. Therefore, in PPP research as part of Public Sector Accounting Literatures has shown that Public Policy Strategy as part of government’s role in shaping the regulatory framework and plays an important role to catalyst the infrastructure development into the next level.
CORPORATE GOVERNANCE AND EARNINGS MANAGEMENT: EVIDENCE OF LISTED INDONESIAN COMPANIES
Authors: Natasya Evelyn 
Published: May 2022

The purpose of this research is to investigate the relationship of corporate governance such as competence of board commissioner and audit committee, audit quality and earnings management in 434 manufacturing sector companies listed in Indonesia Stock Exchange period year 2016-2018. Earnings management proxied by discretionary accrual and profitability proxied by return-on-asset. The results of this study are: (1) firm’s size as control variable is significantly negative influences earnings management (2) profitability which proxied by return-on-asset is significantly negative influences earnings management. Meanwhile, this research did not find support evidence that competence of board commissioner, competence of audit committee, audit quality, revenue growth connection significantly influences on earnings management. Companies can analyze the earnings management through company size and financial ratios such as profitability.
THE COMPARATIVE ANALYSIS OF FINANCIAL PERFORMANCE AND TRADING VOLUME DURING MERS AND COVID-19 ON THE INDONESIA AND MALAYSIA STOCK EXCHANGE
Authors: Hamid Agustini , Arshanty Risky 
Published: May 2022

We investigate the differences of financial performance and stock trading volume during the MERS and COVID-19 periods on the Indonesia and Malaysia Stock Exchanges. We used Wilcoxon Signed Rank Test. Wilcoxon Signed Rank Test model is selected because we compared Indonesia and Malaysia to conduct a paired difference test of repeated measurements on a single sample to assess whether their population mean ranks differ. Our sample consist of 140 companies that getting from 713 companies listed in the Indonesia Stock Exchange while Malaysia is composed of 345 companies from 597 listed company in Malaysia Stock Exchange. The results showed that MERS and COVID-19 have differences in total asset turnover (TATO) and stock trading volume on the Indonesia and Malaysia Stock Exchanges, while the Current Ratio as liquidity ratio and Debt to equity ratio as risk proxy have no differences on the Indonesia and Malaysia Stock Exchange. There is no difference in the operating Profit Margin as profitability ratio variable on the Indonesia Stock Exchange while there is a significant difference on the Malaysia Stock Exchange.
Impacts of changing conditions on the ecological environment of the Shiyang River Basin, China
Authors: Jun Z. J. , Ming L. K. , Qiang C. Y. , Min W. , Xin P. Z. 
Published: May 2022

Abstract
The effect of climate change and human activities on water resources, glaciers, and land use/cover has been widely studied. The Shiyang River Basin is an important natural reserve in the Hexi Corridor of Gansu Province. Global warming and human activities have led to extreme ecological changes in this region. Exploring the response of the ecological environment of the Shiyang River Basin to a changing climate is important for studying the sustainable development of the fragile ecological environment in this basin. The meteorological data for this study was obtained from the China Meteorological Data Service Center, and the average temperature and precipitation data were acquired from four meteorological stations. By investigating the changes in the watershed climate and social environment in the Shiyang River Basin, the corresponding changes in glacial and surface water resources, landscape patterns, and natural and anthropogenic factors in the basin under changing environment were analysed. The results show that the temperature in different seasons has increased in the past 60 years, and the inclination rate of air temperature was 0.56 °C/10a. In addition, precipitation increased slightly at 0.737 mm/10a. Natural conditions and climate change have reduced the supply of glacial meltwater in the Qilian Mountains, and the regulation of glacial snow in downstream rivers is poor. The distribution of the water production rate in each river was similar to that of precipitation. The runoff modulus of the deep mountain area was greater than that of the shallow mountainous area. The western region is larger than the eastern region, and the rationalisation of the land use structure in the basin has a decisive effect on optimising the landscape pattern of the basin. The spatial evolution of the vegetation cover in the basin is generally stable; under the combined action of climate change and human activities, downstream water resources are reducing, and landscape vegetation is shifting to a high risk in the Shiyang River Basin. Among the influencing factors, anthropogenic factors play a dominant role in the runoff variation in this basin. Climate warming and unregulated human activities are the main causes of regional environmental deterioration. The study findings can contribute to understanding the coupling relationship between the natural and ecological evolution process of the inland river basin and human activities in the arid zone. Further, exploring the change trend of the ecological environment of the Shiyang River Basin can help determine the human adaptation countermeasures to mitigate ecological deterioration and ensure sustainable development of ecologically fragile areas.
Computational fluid dynamics based numerical simulations of heat transfer, fluid flow and mass transfer in vacuum membrane distillation process
Authors: Yadav Anshul , Singh Chandra Prakash , Patel Raj Vardhan , Labhasetwar Pawan Kumar , Shahi Vinod Kumar 
Published: May 2022

Abstract
In this study, we developed a comprehensive two-dimensional computational fluid dynamics (CFD) model using COMSOL™ Multiphysics to describe and simulate heat transfer, mass transfer and fluid flow in the flat sheet vacuum membrane distillation (VMD) under laminar flow conditions. A combination of Knudsen and Poiseuille flow was applied to study mass transfer across the membrane. The effect of variation of Reynolds number, inlet feed temperature and degree of vacuum on different parameters (mass flux, temperature polarization coefficient- TPC, concentration polarisation, heat transfer coefficient) was studied. There was a positive impact of the Reynolds number (50–200) on mass flux (13.15%), heat transfer coefficient (2.64%) and TPC (1.42%), while CPC decreased by 56.63%. The increment in the heat transfer coefficient was due to fluid mixing on the feed side, while the increment in the TPC was due to a higher temperature gradient across the membrane surfaces. The increment in the feed temperature (323–343 K) resulted in an increase in mass flux by 132.9%, while TPC decreased from 0.98 to 0.90. The degree of vacuum (640–750 mm Hg) increased mass flux and heat transfer coefficient by 72.52 and 425.83%, respectively, while the TPC decreased by 8.81%. The feed temperature was the most sensitive parameter with respect to mass flux. The developed CFD model was validated with in-house experimental results with reasonable accuracy.
High specific surface area N-doped activated carbon from hydrothermal carbonization of shaddock peel for the removal of norfloxacin from aqueous solution
Authors: Niu Xinyong , Liu Chenglin , Li Lin , Han Xiuli , Chang Chun , Li Pan , Chen Junying 
Published: May 2022

Abstract
A novel N-doped activated carbon (NAC) derived from shaddock peel was investigated to remove norfloxacin (NFX) from aqueous solution. The Box-Behnken central composite design (BBD) was used to optimize the preparation conditions of NAC. The specific surface area of NAC was 2,481.81 m2 g−1, which was obtained at 1,106 K activation temperature, 2.4 h residence time, and 2.3:1 mass ratio of KOH to hydrochar. Moreover, the equilibrium data were perfectly represented by Langmuir and Koble-Corrigan isotherms, and the adsorption process was precisely described by the pseudo-second-order kinetic model. Besides, the adsorption of NFX on NAC was mainly controlled by π-π electron-donor-acceptor (EDA) interaction, hydrophobic effect, hydrogen-bonding, electrostatic interaction and Lewis acid-base effect. The maximum monolayer adsorption capacity of NFX was 746.29 mg g−1 at 298 K, implying that NAC was a promising adsorbent for the removal of NFX from aqueous solution.