bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sistem Informasi Manajemen Laboratorium Komputer (Simlab - Kom) Program Studi Pendidikan Teknologi Universitas PGRI Semarang
Authors: Aviany Yolland , Sudargo Sudargo , Menarianti Ika 
Published: July 2022

Laboratorium komputer di jurusan pendidikan teknologi informasi Universitas PGRI Semarang masih memiliki kendala serta kegiatan – kegiatan di dalamnya masih bersifat manual sehingga diperlukannya sebuah sistem untuk membantu pengelolaan laboratorium komputer di jurusan pendidikan teknologi informasi. Metode yang digunakan dalam penelitian ini adalah metode studi pustaka, observasi dan wawancara. Data yang ada kemudian dianalisis dengan menggunakan metode waterfall, yang mana tahapannya meliputi: tahap Communication, Planning, Modelling, Contruction dan Deployment dengan desain sistem meliputi: Perancangan Flowchart System, DFD, ERD, DIPO, dan Perancangan Tabel. Penelitian ini kemudian diimplementasikan ke dalam bahasa pemprogaman PHP dengan menggunakan database MySQL. Pengujian aplikasi yaitu dengan validasi kepada ahli media dan ahli materi dalam bentuk angket. Pada proses pengujian yang dilakukan oleh ahli media diperoleh persentase rata-rata sebesar 88% dan masuk ke dalam kategori sangat layak, dan pada proses pengujian black box dinyatakan layak, sedangkan untuk hasil pengujian pada responden dalam hal ini adalah mahasiswa, mendapatkan persentase rata-rata sebesar 89% dan dikategorikan sangat layak.
Preexisting coronary artery disease among coronavirus disease 2019 patients: a systematic review and meta-analysis
Authors: Zuin Marco , Rigatelli Gianluca , Bilato Claudio , Rigatelli Alberto , Roncon Loris , Ribichini Flavio 
Published: July 2022

Aims
The prevalence and prognostic implications of coronary artery disease (CAD) in patients infected by the novel coronavirus 2019 (COVID-19) disease remain unclear.

Methods
We conducted a systematic review and meta-analysis to investigate the prevalence and mortality risk in COVID-19 patients with preexisting CAD. We searched Medline and Scopus to locate all articles published up to December 8, 2021, reporting data of COVID-19 survivors and nonsurvivors with preexisting CAD. Data were pooled using the Mantel-Haenszel random effects models with odds ratio (OR) as the effect measure with the related 95% confidence interval (CI).

Results
Thirty-eight studies including 27 435 patients (mean age 61.5 and 70.9 years) were analysed. The pooled prevalence of preexisting CAD was 12.6% (95% CI: 11.2–16.5%, I
2: 95.6%), and resulted as higher in intensive care unit patients (17.5%, 95% CI: 11.9–25.1, I
2: 88.4%) and in European cohorts (13.1%, 95% CI: 7.8–21.6%, P < 0.001, I
2: 98.4%). COVID-19 patients with preexisting CAD had a two-fold risk of short-term mortality (OR 2.61, 95% CI 2.10–3.24, P < 0.001, I
2 = 73.6%); this risk was higher among Asian cohorts (OR: 2.66, 95% CI: 1.79–3.90, P < 0.001, I
2: 77.3%) compared with European (OR: 2.44, 95% CI: 1.90–3.14, P < 0.001, I
2: 56.9%) and American (OR: 1.86, 95% CI: 1.41–2.44, P < 0.001, I
2: 0%) populations. The association between CAD and poor short-term prognosis was influenced by age, prevalence of hypertension (HT), DM and CKD.

Conclusions
Preexisting CAD is present in approximately 1 in 10 patients hospitalized for COVID-19 and significantly associated with an increased risk of short-term mortality, which is influenced by age, HT, DM and CKD.
Myocardial fibrosis in asymptomatic patients undergoing surgery for mitral and aortic valve regurgitation
Authors: Fragasso Gabriele , Sanvito Francesca , Monaca Giuseppe , Ardizzone Valentina , De Bonis Michele , Pappalardo Federico , Smart Chanel , Montanaro Claudia , Lapenna Elisabetta , Calabrese Maria Chiara , Castiglioni Alessandro , Benussi Stefano , Maisano Francesco , Zangrillo Alberto , Ambrosi Alessandro , Doglioni Claudio , Alfieri Ottavio , Margonato Alberto 
Published: July 2022

Background
Chronic heart valve regurgitation induces left ventricular (LV) volume overload, leading to the development of hypertrophy and progressive dilatation of the ventricle to maintain physiological cardiac output. In order to prevent potential irreversible LV structural changes, the identification of the best timing for treatment is pivotal.

Objective
To assess the presence and extent of fibrosis in myocardial tissue in asymptomatic patients with valvular heart disease (VHD) and preserved LV dimensions and function undergoing cardiac surgery.

Methods
Thirty-nine patients were enrolled. Sixteen patients were affected by aortic or mitral regurgitation: they were all asymptomatic, undergoing valve surgery according to VHD European Society of Cardiology guidelines. Twenty-three patients with end-stage nonischemic dilated cardiomyopathy (DCM) and severe LV dysfunction undergoing cardiac surgery for implantation of a durable left ventricular assist device (LVAD) served as controls. During surgery, VHD patients underwent three myocardial biopsies at the level of the septum, the lateral wall and LV apex, while in LVAD patients the coring of the apex of the LV was used. For both groups, the tissue samples were analyzed on one section corresponding to the apical area. All slides were stained with hematoxylin and eosin and Masson's trichrome staining and further digitalized. The degree of fibrosis was then calculated as a percentage of the total area.

Results
Of 39 patients, 23 met the inclusion criteria: 12 had mitral or aortic insufficiency with a preserved ejection fraction and 11 had idiopathic dilated cardiomyopathy. Quantitative analysis of apical sections revealed a myocardial fibrosis amount of 10 ± 6% in VHD patients, while in LVAD patients the mean apical myocardial fibrosis rate was 38 ± 9%. In VHD patients, fibrosis was also present in the lateral wall (9 ± 4%) and in the septum (9 ± 6%).

Conclusion
Our case series study highlights the presence of tissue remodeling with fibrosis in asymptomatic patients with VHD and preserved LV function. According to our results, myocardial fibrosis is present at an early stage of the disease, well before developing detectable LV dysfunction and symptoms. Since the relationship between the progressive magnitude of myocardial fibrosis and potential prognostic implications are not yet defined, further studies on this topic are warranted.
A positive syn-fold test from the Neoarchaean Klipriviersberg Group of South Africa: Quo vadis Vaalbara?
Authors: de Kock M.O. , Malatji I. , Wabo H. , Maré L.P. 
Published: July 2022

Abstract
The existence of Vaalbara, the combined Neoarchaean to Palaeoproterozoic Kaapvaal-Pilbara supercraton, is questionable during the early Neoarchaean when scrutinised through the lens of recent Australian and South African palaeomagnetic data. Remarkably similar ~2.7 to 2.5 Ga geological successions (with near bed-for-bed correlatability) support a coherent Vaalbara at the end of the Neoarchaean. Here we report palaeomagnetic and rock magnetic results from the Klipriviersberg Group of South Africa, which is the oldest rock sequences used to define Vaalbara originally. A positive syn-fold test illustrated a high-temperature remanence component acquired during the formation of the Witwatersrand syncline. This fold structure predates the Vredefort Impact Structure and its formation is synchronous with the deposition of the Mesoarchaean Central Rand Group and extrusion of the Klipriviersberg Group. The studied rocks of the Klipriviersberg Group are not directly dated, but most are likley younger than 2 780 to 2 789 Ma, based on detrital zircon ages from the lowermost Ventersdorp Supergroup and U-Pb baddeleyite ages for mafic sills that intrude the Witwatersrand Supergroup that are regarded as feeders of the Kliprivierberg Group lavas, but older than the overlying 2 720 to 2 750 Ma Platberg Group. The Klipriviersberg Group pole is at 27.7°S, 32.7°E with an A95 of 11°. A comparison of Meso- to Neoarchaean palaeopoles from the Kaapvaal and Pilbara cratons suggests their shared drift path traversing the polar circle and thus supports the existence of Vaalbara across the 2.78 to 2.70 Ga interval.
A case of hydrocephalus confounded by suprasellar arachnoid cyst and concomitant reversible cerebral vasoconstriction syndrome
Authors: Ahmad Samuel Jack , Zampolin Richard L. , Brook Allan L. , Kobets Andrew J. , Altschul David J. 
Published: July 2022

Background:
Obstructive hydrocephalus is a neurologic condition that has varied clinical and imaging presentations, as well as a multitude of congenital etiologies including aqueductal stenosis and less commonly arachnoid cysts. Aqueductal stenosis is a physical limitation to cerebrospinal fluid flow along the course of the aqueduct, which results in enlargement of the third and lateral ventricles. Arachnoid cysts are thin walled and fluid filled central nervous system lesions that can result in mass effect on adjacent structures. While arachnoid cysts are mostly asymptomatic, they may present with neurological symptoms that vary depending on the location of the lesion. Suprasellar cysts in particular may cause obstructive hydrocephalus as well as endocrine dysfunction. Reversible cerebral vasoconstriction syndrome (RCVS) is an unusual condition caused by cerebral arterial vasoconstriction that often presents initially with a thunderclap headache. Frequently, there is some environmental trigger associated with this condition. RCVS more commonly affects women and can induce stroke.

Case Description:
A 57-year-old female presented to the emergency department with progressive headache and visual changes. Initial workup suggested the patient’s symptoms where related to RCVS but subsequent surgical management of what was presumed to be long standing, compensated hydrocephalus resulted in resolution of the patient’s symptoms.

Conclusion:
We report, to the best of our knowledge, the first case of aquedutal stenosis and suprasellar arachnoid cyst with concomitant RCVS. The presence of multiple pathologies found on radiologic imaging illustrates the challenges presented by incidental findings and subsequent anchoring bias in medical diagnosis.
Motor outcome after resective surgery for the central lobe gliomas
Authors: Mamani Rocio , Jacobo Javier A. , Guinto-Nishimura Gerardo Yoshiaki , Hernández-Hernández Alan , Moreno-Jimenez Sergio 
Published: July 2022

Background:
Extent of resection (EOR) plays a major role in the prognosis on patients with gliomas, although the postoperative functionality of the patient is of great importance as well. It is why many surgeons advocate to not operate extensively on tumors that involve eloquent regions such as the central lobe. Recent series have demonstrated that it is possible to achieve extensive resections in this area without significantly affecting the functional outcome for these patients. We illustrate this issue with the experience obtained at the National Institute of Neurology and Neurosurgery in Mexico City.

Methods:
This is an observational and retrospective study that included patients that received surgical resection for intracranial gliomas that involved the central lobe at the National Institute of Neurology and Neurosurgery of Mexico, between January 2017 and May 2020. Demographic and clinical variables of the patients at the time of diagnosis were collected as well as tumor morphological variables, surgical adjuncts, and clinical outcomes. Statistical analysis was performed with SPSS software.

Results:
A total of 28 patients were included in the study with 43% of patients having a motor deficit before surgery. The average EOR was 88.6%. Patients presented with worsening of their motor status in the immediate postoperative period in 21% of the cases, although most of the patients recovered within the 1st month of follow-up. After analyzing all variables, not having a presurgical motor deficit was a statistically significant risk factor for developing a new motor deficit in the immediate postoperative period (P: 0.02).

Conclusion:
A resective surgery for gliomas near or within the central lobe can be performed safely and a satisfactory motor outcome for patients can be achieved without sacrificing the EOR. An intact presurgical motor status is a risk factor for developing a new deficit after surgery.
Mutation of the Glc-2 Gene May Confer Dominant Ivermectin Resistance
Authors: Su Hong , Dent Joseph 
Published: July 2022

Background: Ivermectin is a widely used anti-parasitic drug that binds to and activates glutamate-gated chloride channels (GluCls), giving it its nematocidal (nematode-killing) properties. Due to excessive use of ivermectin, frequent cases of resistance to this nematicide are being reported, suggesting that ivermectin is beginning to lose its efficacy. This project seeks to study whether a mutation of the glc-2 gene, which encodes for a β subunit of the GluCl channel, confers ivermectin resistance. We hypothesize that a glc-2 mutation achieves nematicide resistance by creating a defective GluCl channel that cannot bind to ivermectin.
Methods: We used classical genetics to obtain the desired mutants from stock worms. We then tested the worms for resistance profile using ivermectin sensitivity assays. Finally, we examined in vivo interactions by expressing relevant RNA in a heterologous system and performed electrophysiological recordings.
Results: We were able to demonstrate that presence of the defective glc-2 leads to increased resistance profiles when given the chance to associate with select GluClα subunits (e.g. AVR-15). We also demonstrated that co-injection of glc-2 and glc-3 compromises GluCl response to L-glutamate, a critical indicator of channel functionality.
Conclusion: Our results lend strong support to our hypothesis that glc-2 is able to interact with certain α subunits of GluCl to confer ivermectin resistance. This finding provides a framework for future dominant ivermectin resistance studies.
Cosmic Strings and The Origins of Globular Clusters
Authors: Barton Alistair , Lin Ling , Yamanouchi Shoma 
Published: July 2022

Background: Globular clusters are galactic structures whose origin is not well understood. In this paper we propose that their origin may be found in the accretions formed around cosmic string loops.
Methods: To test this hypothesis we derived the mass distribution that would be associated with the ac- cretions and compared it to the observed mass distribution of globular clusters in our galaxy. Our derived distribution left us one free parameter (cosmic string tension) which we varied to optimize the ﬁt. Once optimized, we compared the shape of the distribution and the number density that our model predicted with empirical observations. Later, we derived how velocity effects would alter the shape of this distribution.
Results: We achieved signiﬁcant agreement between our model and observed values. Furthermore, the op- timal tension corresponds to particle physics theories that have not been ruled out. Our analysis further suggests that globular clusters form around slowly moving (< 3% the speed of light) cosmic string loops; any model with signiﬁcantly faster cosmic string loops would contradict our hypothesis.
Limitations: Our results were obtained by using numerous approximations (such as the Zel’dovich approx- imation) and thus should be treated as an order of magnitude estimation. Our data was also limited to observed globular clusters within the Milky Way, limiting our sample size to approximately 120 globular clusters.
Conclusions: We managed to obtain strong agreement between our model and observed globular clusters, suggesting that they may be seeded by cosmic string loops. This also serves to explain many other charac- teristics of globular clusters, such as age, density and location. The analyses used in this report can also be used when considering the formation of other accretion objects, such as ultra-compact-minihalos.
Selecting for multicellularity in the unicellular alga Chlamydomonas reinhardtii
Authors: Moulton Tyler , Bell Dr. Graham 
Published: July 2022

Background: Researchers have recently begun experimentally exploring the origins of multicellularity (4-6). Their studies have found that the transition to a multicellular state may have been surprisingly simple, considering its profound implications for the history of life (3). This study experimentally selected for multicellularity in the unicellular biflagellated alga Chlamydomonas reinhardtii. This organism is especially interesting because it is basal to the Volvocaceae—a family of biflagellates whose evolutionary transition from unicellular organisms to complex forms have been meticulously characterized (2). The present study aimed to recreate the early stages of this transition, starting from incomplete cytokinesis after cell division.
Methods: The procedure was modeled loosely on the experiment performed by Ratcliff et al. (4) in which the authors successfully selected for multicellular Saccharomyces Cerevisiae—unicellular baker’s yeast. Three experimental replicates and one control for nine strains of C. reinhardtii were cultured in round-bottom vials in shaking incubators. Prior to each transfer (every 3-4 days), each culture was slowly mixed, and selection lines were then gently and briefly centrifuged. This applied a selection pressure which rendered heavier (clustered) cells more fit. The very bottom ~2% of the tubes’ contents was transferred, and cell cultures were examined for multicellularity.
Results: Six of nine lines of C. reinhardtii demonstrated an increased frequency of C. reinhardtii existing in a two- to four-celled state (the paired cell state accounted for 88% of these clusters)—consistent with the first step toward multicellularity as outlined by Kirk (2). A close study of cell division in the line which exhibited the strongest shift towards the multicellular phenotype suggests that true multicellularity began to evolve in this experiment. A multicellular phenotype did not become fixed in any population.
Conclusion: Our findings suggest that an artificial selection pressure is capable of inducing the evolution of multicellularity. Expanding upon this study could help us understand the mechanisms underlying the evolution of multicellularity.
Limitations: Sporadic data, possibly the result of difficulties in the procedure, prevented us from rigorously examining the effect of selection through time, limiting our ability to describe the evolutionary response. In addition, the study of individual cells, due to its time-consuming nature, was limited to one replicate of one line exhibiting a pronounced multicellular response. Thorough replication would be required before drawing a strong conclusion from this assay.
Development and Characterization of a Directional Gamma-ray Detector
Authors: Cormier Felix , Georgin Marcel , Koelbl Stephen , Oda Robert 
Published: July 2022

Background: This work characterizes the first generation of detectors from the Hanna Laboratory to implement Silicon Photomultipliers and a heptagonal scintillator conguration. The purpose of the device is to determine the angle at which a radioactive source is located.
Methods: The development of the detector consisted of three phases: construction(September 2012- December 2012), simulation and characterization (April 2013). The experimental portion of the work consisted of placing a 137 Cs source at an arbitrary location, measuring the count rates in each scintillator panel and analysing the results.
Results: The detector’s function was validated by confirming the inverse square law with a radioactive source moving away from the detector. Furthermore, with a x2 summation method of analysis the angular position of a source was determined with an accuracy of 10˚ and a precision of 12˚. With a normalisation method of analysis the angular position of a source was found with an accuracy of 2˚ and a corresponding precision of 2˚.
Limitations: The quality of the electronics handling the signal from the silicon photomultipliers limited our resolution. Occasional double counts occur when a large amount of energy is imparted to the scintillator. Furthermore, the custom-built circuitry lowered the signal-to-noise ratio such that large distances were not feasible due to electronic noise constraints. Finally, simulation data analysis showed that the break of one circuit only had a small effect on the x2 method of analysis.
Conclusions: In conclusion, the design of the detector and the analysis techniques were shown to be suitable for short range angular resolution of a gamma-ray source. Both distance trials and a simulation of the detector prototype confirmed the validity of our design and of the analysis methods used. These promising results at short distances motivate further work in electronic circuit design to improve the range while maintaining both accuracy and precision.
Introducción
Authors: Gónzález Grandón Ximena , López Pérez Lourdes 
Published: July 2022

Referencias
Freire, P. (1997). A la sombra de este árbol. Barcelona, España: El Roure.
Freire, P. (2017). Pedagogía de la esperanza. Ciudad de México, México: Siglo xxi.
Freire, P. (2019). Pedagogía del oprimido. Ciudad de México, México: Siglo xxi.
González-Grandón, X. A. (2021). Cuerpos conscientes y afectos regulados: la interocepción en la educación socioemocional. Revista Internacional de Educación Emocional y Bienestar, 1(2), 101-124.
Learning Without Frontiers (lwf). (1 de febrero de 2012). Noam Chomsky - The purpose of education [Archivo de video]. https://www.youtube.com/watch?v=DdNAUJWJN08&t=4s
PERANCANGAN ALAT BANTU DENGAN METODE CONJOINT ANALYSIS DAN QUALITY FUNCTION DEPLOYMENT (QFD) BERDASARKAN PRINSIP ERGONOMI
Authors: Rembulan Glisina Dwinoor , Maratama Septiawan 
Published: July 2022

<p><em>The industrial sector in Indonesia has experienced rapid development in the last 10 years. The manufacturing industry is the sector that contributes the largest export value at USD 105.11 billion or Rp. 1,438 trillion (exchange rate of Rp. 13,686/USD) during January to October 2019. PT. PJM is a manufacturing company that produces electrical panels. In production activities, PT. PJM still does a lot of work manually or Manual Material Handling (MMH) and has poor work postures. MMH activities and wrong and inappropriate work postures are the main sources of worker complaints that can pose ergonomic risks to workers. Ergonomics intervention in the design of assistive devices is carried out to help prevent the risk of MSDs and ergonomics in the workplace. The purpose of this study was to improve work posture and reduce the risk of MSDs in workers. The results of this study indicate that the highest exposure level is at the welding station, namely 60.79%, which is included in the category that needs further research and changes are made. However, after implementing the design of assistive devices at the welding station, there was a decrease in the exposure level value of 33.59%, which was included in the safe category. The implementation of the design of the tool has succeeded in improving the work posture and the risk of MSDs of workers at the welding station.</em></p><p><strong><em> </em></strong></p>