bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Case of Warfarin Resistance in a Patient with Prosthetic Heart Valves and the CYP2C9*1*1-VKORC1GG Genotype
Authors: Николаев Е.Е. , Богданов А.В. , Павлова С.И. , Богданова С.М. 
Published: March 2022

Использование непрямых антикоагулянтов, в частности варфарина, является обязательным для профилактики тромбозов у пациентов с протезированными клапанами сердца. В статье представлен клинический случай резистентности к варфарину у пациента с имплантированными митральным и аортальным клапанами. В период его стационарного лечения наблюдались трудности в подборе дозы варфарина для достижения целевого международного нормализованного отношения (МНО), отмечались тромбоэмболические и геморрагические осложнения. В публикации рассмотрены генетические и другие факторы, с которыми могла быть связана устойчивость к действию варфарина у данного пациента. Приведены современные сведения из литературных источников о связи резистентности к варфарину с выявленными в результате фармакогенетического тестирования аллельными вариантами генов CYP2C9, VKORC1. На сегодняшний день наиболее изучены полиморфизмы, предопределяющие повышенную чувствительность к варфарину, поэтому существуют конкретные рекомендации для снижения стартовых дозировок препарата. Данный клинический случай демонстрирует необходимость при подборе дозы варфарина уделять пристальное внимание генотипу CYP2C9*1*1-VKORC1GG, роль которого в наличии устойчивости к действию варфарина еще нуждается в дальнейшем исследовании.
The use of indirect anticoagulants, in particular warfarin, is mandatory for the prevention of thrombosis in patients with prosthetic heart valves. We present a clinical case of a patient with implanted mitral and aortic valves, who is resistant to warfarin. There were difficulties in selecting a dose of warfarin to achieve the target INR during the inpatient treatment. Thromboembolic and hemorrhagic complications were noted. In the paper, there are considered genetic and other factors that could be associated with warfarin resistance in this patient. Present-day information from the literature on the relationship of warfarin resistance with allelic variants of the CYP2C9 and VKORC1genes identified as a result of pharmacogenetic testing is discussed. By now, the most studied are the polymorphisms that determine the increased sensitivity to warfarin, so there are specific recommendations for reducing the starting dosages of the drug. This clinical case demonstrates the need to pay close attention to the CYP2C9*1*1-VKORC1GG genotype when selecting the dose of warfarin, the role of which in the warfarin resistance still needs further careful research.
Comparative evaluation of lethal outcome prediction methods in severely burned patients
Authors: Zavorotniy O. O. , Zinoviev E. V. , Volkov V. G. , Kostyakov D. V. , Halipaeva D. H. , Semiglazov A. V. , Gogohiya T. Z. 
Published: March 2022

Background: Regarding burn injury there are many approaches to assessing the possibility of death in severely burned patients. Despite the ease of use and the maximum prevalence of existing models, the assessment of the outcome in each of them is questionable, since the emphasis in different indices is on different indicators, avoiding the overall clinical picture of the disease.Objective: Comparative analysis of the effectiveness of methods for predicting a lethal outcome in patients with extensive skin burns.Material and мethods: Calculated characteristics of known in the literature and widely used Baux rules, Frank index, probit analysis and a new method of logistic regression were obtained and applied to evaluate the results of treatment of 282 adult patients with extensive skin burns, hospitalized in the Department of Anesthesiology and Intensive Care of the Thermal Injuries Unit, Saint-Petersburg I. I. Dzhanelidze Research Institute of Emergency Medicine in the period 2015–2021.Results: During the study a descriptive characteristic of methods for predicting a lethal outcome was obtained. Based on the data obtained, four-field contingency tables were compiled and a comparative analysis of the effectiveness of the models was carried out.Conclusion: Despite the high frequency of use of such forecasting methods as the Baux score, the Frank index and probit analysis in the combustiology practice, the results of the calculation indicate that these methods have low efficiency: the Baux score method accuracy of a lethal outcome prediction is 49.7%, the Frank index method – 41.5%, probit analysis method – 60%. The logistic regression model developed by us showed high efficiency compared to those presented earlier (the accuracy of predicting a lethal outcome was 93%), which gives grounds for recommending it for practical application.
PENUNDAAN KEWAJIBAN PEMBAYARAN UTANG KOPERASI YANG DIAJUKAN OLEH ANGGOTANYA
Authors: Maulisa Nadia , Tanjung Kurnia Togar P. , Fredriana Gerardiene 
Published: March 2022

Modal usaha koperasi terdiri dari modal sendiri dan modal pinjaman. Modal sendiri, utamanya berasal dari iuran para anggota koperasi itu sendiri. Modal pinjaman, antara lain berasal dari pinjaman kepada anggota koperasi itu sendiri pula. Sebagaimana pinjaman pada umumnya, modal usaha koperasi yang berasal dari pinjaman kepada anggotanya, berpotensi terjadi penundaan bahkan gagal pengembalian. Penundaan dan/atau kegagalan pengembalian tersebut dapat menimbulkan perselisihan. Penyelesaian perselisihan, dapat dengan dilakukan dengan menempuh upaya hukum Penundaan Kewajiban Pembayaran Utang Koperasi. Rumusan masalah yang diangkat dalam penelitian ini adalah hak dan kedudukan hukum anggota koperasi yang mengajukan upaya hukum Penundaan Kewajiban Pembayaran Utang terhadap koperasi. Metode penelitian yang diterapkan adalah penelitian yuridis-normatif. Simpulan yang diperoleh adalah terkait modal pinjaman koperasi yang berasal dari anggotanya maka upaya hukum Penundaan Pembayaran Kewajiban Utang dapat diajukan oleh anggota koperasi yang bersangkutan. Pengajuan upaya hukum Penundaan Pembayaran Kewajiban Utang oleh anggota koperasi, menempatkan yang bersangkutan sebagai kreditur konkuren.
Low-loss characteristics of coplanar waveguides fabricated by directly bonding metal foils to high-resistivity Si substrates
Authors: Yonekura Kenya , Kawamoto Tasuku , Liang Jianbo , Shikoh Eiji , Maezawa Koichi , Shigekawa Naoteru 
Published: March 2022

Abstract
Coplanar waveguides (CPWs) are fabricated by directly bonding 17 μm Al foils to Si substrates with different resistivities and wet etching. Their RF characteristics are compared with those of CPWs fabricated on 0.8 μm thick evaporated Al layers. A lower insertion loss is observed for Si substrates with higher resistivity irrespective of the thickness of conductors because the substrate loss is decreased. For a 10000-Ω · cm Si substrate, Al-foil-based CPWs reveal a ∼0.7 dB cm−1 lower insertion loss in comparison with evaporated-Al-based CPWs at 1 GHz. These features agree with the calculation, which implies the superiority of direct bonding of metal foils for realizing low-loss passive components.
TELAAH MINIMNYA APRESIASI PADA KARYA SENI GRAFIS DI SUMATERA KHUSUSNYA DI KOTA PALEMBANG
Authors: Iswandi Heri 
Published: March 2022

<p><em> Sebagai kata benda abstrak ‘seni’ adalah kemampuan kreatif manusia dalam menanggapi alam; kemampuan istimewa dalam mangubah suatu ide menjadi konsep kreatif yang dinyatakan menjadi suatu yang menarik, fungsional atau inspiratif. Seni adalah hasil karya manusia yang dibuat melalui proses pengerjaan yang memerlukan ketrampilan khusus atau luar-biasa. Dalam berkarya seni, kepentingan pribadi bagi si senimannya tentunya berbeda-beda, ini disebabkan oleh kebutuhan hidup dan pemaknaan hidup yang bebeda-beda pula.</em><em> </em><em>Kepentingan pribadi yang bebeda-beda semacam itu mengakibatkan penikmat seni juga mencari sendiri nilai-nilai pribadinya pada sebuah karya seni, dan hal tersebutlah yang membuat seseorang memiliki apresiasi seni yang berbeda-beda. Salah satu cabang seni murni, yaitu </em><em>seni grafis dalam kaitannya dengan media ataupun teknik yang dipakai dalam pengungkapan kreatifitas seni grafis seharusnya tidak perlu diperdebatkan, yang utama adalah seni grafis yang me-Indonesia, yang menunjukkan identitas grafis yang dimiliki Indonesia tanpa terpengaruh oleh negara lain.</em><em> Karya seni grafis selalu lekat dengan teknik dan medium yang digunakan.</em><em> </em><em>Sejak seni grafis berkembang di Indonesia, perkembangannya seakan semakin merosot tajam. Seni grafis menjadi cabang seni murni yang konvensional dengan teknik dan mediumnya. Namun lama-kelamaan pemikiran itu mulai hilang dengan adanya karya-karya seni grafis baru yang merespon kekayaan teknik dan medium. disertai oleh pemikiran konsep yang plural. Di dalam penelitian ini, penulis mencoba untuk menelusuri fungsi seni grafis di tengah masyarakat, Khususnya di kota Palembang. Seni grafis sebagai salah satu medium seni rupa memang belum sepopuler seni lukis, patung, dan bahasa rupa lainnya. Seni grafis baru terindentifikasi ketika bersinggungan dengan ranah pendidikan. Padahal seni grafis sudah dikenal di Indonesia sejak 1940-an. Banyak hal yang membuat seni grafis sebagai bahasa rupa kurang memasyarakat. Namun, bukan berarti seni grafis tidak mempunyai nilai lebih dari genre seni rupa lainnya. </em></p>
PERANCANGAN KAMPANYE SOSIAL BAHAYA PENGGUNAAN POLISTIRENA BUSA SEBAGAI KEMASAN MAKANAN DAN MINUMAN PADA KALANGAN PEDAGANG DI KOTA PALEMBANG
Authors: Riansyah Raden Okta , Mubarat Husni , Yulius Yosef 
Published: March 2022

<p><em>Penggunaan kemasan polistirena busa yang berkali kali pada jenis sekali pakai dapat menyebabkan penyakit terhadap kesehatan manusia mulai dari menganggu sistem syaraf, alergi kulit, sulit tidur, iritasi mata, diare bahkan dapat memicu kanker. Untuk di Kota Palembang, sampai saat ini masih banyak pedagang makanan yang menggunakan polistirena busa sebagai kemasan makanan, seperti pedagang bubur ayam, seblak, dan nasi goreng, tanpa menyadari bahaya yang ditimbulkan. Oleh karena itu perlu adanya perancangan kampanye sosial mengenai dampak penggunaan polistirena busa yang berlebihan. Adapun metode pengumpulan data pada perancangan karya ini dititikberatkan pada identifikasi data, analisadata dan perancangan pada karya Ambient media tempat sampah dan media pendukung lainnya. Perancangan ini menggunakan metode perencanaan design thinking meliputi premedia, main media dan follow up media. Data dikumpulkan melalui, observasi, wawancara, literatur dan website. Data tersebut kemudian diidentifikasi, diklasifikasi, diseleksi, selanjutnya dianalisis menggunakan metode 5W+1H, dan diinterpretasikan sesuai teks dan konteksnya. Perancangan ini bertujuan mengajak masyarakat Kota Palembang khususnya para pedagang untuk beralih ke kemasan yang lebih Higenis. Adapun karya yang dibuat pada perancangan ini diantaranya adalah ambient media berupa tempat sampah, poster, apron, T-Shirt, Masker, dan X Banner. </em></p>
El reverso que no vemos. Hallazgo de un conjunto gótico actualmente disperso a partir del estudio del soporte.
Authors: Bautista Morenilla Iris , Nualart Torroja Anna , Oriola-Folch Marta 
Published: March 2022

Este estudio confirma que el frontal de santa Eugenia (MAD 121, París) y los laterales de Ribes (MEV, 9494/9495) formaban un conjunto que originalmente guarnecía el altar principal de la iglesia románica de santa Eugenia de Saga (Cerdaña, Cataluña). Al conjunto se le perdió el rastro tras la venta del frontal a un anticuario francés en 1896. Frontal y laterales no se habían vuelto a poner en relación debido a las diferencias de la policromía y a su supuesta procedencia distinta hasta la realización de esta investigación.
Las evidencias han sido halladas mediante el análisis científico del soporte y el estudio de los vestigios de policromía conservados en los marcos de las tres obras. Esta es la segunda vez que se ha demostrado la unidad de un conjunto de altar del período del gótico lineal a partir del estudio del soporte, hecho que pone de relieve la importancia de los estudios técnicos de conservación-restauración.
Evidence of attentional bias toward body stimuli in men
Authors: Talbot Daniel , Saleme Daniella 
Published: March 2022

AbstractOver the past 30 years, attentional bias for body shape and weight content has been implicated in the precipitation and maintenance of body dissatisfaction and eating disorders. Although the existence of this bias toward body stimuli is well-established in female populations, it is comparatively understudied in men. This review aimed to examine the nature of this visual attentional bias toward male bodies in male samples across a range of different attentional paradigms, including eye-tracking, dot-probe, and the visual search task. Results were heterogenous, finding some evidence that men with higher body dissatisfaction and eating disorder symptoms demonstrated an attentional bias toward desirable bodies of other men, and undesirable features of their own bodies. These results suggest that schematic cognitive models of body dissatisfaction and eating disorders body may also be applicable to men, however more research is needed.
Tidally Tilted Pulsations in HD 265435, a Subdwarf B Star with a Close White Dwarf Companion
Authors: Jayaraman Rahul , Handler Gerald , Rappaport Saul A. , Fuller Jim , Kurtz Donald W. , Charpinet Stéphane , Ricker George R. 
Published: March 2022

Abstract
Tidally tilted pulsators (TTPs) are an intriguing new class of oscillating stars in binary systems; in such stars, the pulsation axis coincides with the line of apsides, or tidal axis, of the binary. All three TTPs discovered so far have been δ Scuti stars. In this Letter, we report the first conclusive discovery of tidally tilted pulsations in a subdwarf B (sdB) star. HD 265435 is an sdB–white dwarf binary with a 1.65 hr period that has been identified and characterized as the nearest potential Type Ia supernova progenitor. Using TESS 20 s cadence data from Sectors 44 and 45, we show that the pulsation axis of the sdB star has been tidally tilted into the orbital plane and aligned with the tidal axis of the binary. We identify 31 independent pulsation frequencies, 27 of which have between 1 and 7 sidebands separated by the orbital frequency (ν
orb) or multiples thereof. Using the observed amplitude and phase variability due to tidal tilting, we assign ℓ and m values to most of the observed oscillation modes and use these mode identifications to generate preliminary asteroseismic constraints. Our work significantly expands our understanding of TTPs, as we now know that (i) they can be found in stars other than δ Scuti pulsators, especially highly evolved stars that have lost their H-rich envelopes, and (ii) tidally tilted pulsations can be used to probe the interiors of stars in very tight binaries.
The Effect of Topical Ozonated Aloe vera on VEGF Expression and Microvascular Density in Radiation Dermatitis
Authors: Prajoko Yan Wisnu , Silalahi Davin Rizky Parulian , Priharsanti Christina Hari Nawangsih , Supit Tommy 
Published: March 2022

BACKGROUND: Radiation dermatitis is one of the most common side effects of external radiation therapy. Ozonated Aloe vera oil is a novel topical intervention with immunomodulatory properties that have been proven to improve wound healing by promoting fibroblast proliferation and collagen synthesis.

AIM: The purpose of this study was to investigate the effect of topical ozonated A. vera oil application on the vascularization aspect of wound healing in a radiation dermatitis animal model.

METHODS: Thirty-six adult male Sprague Dawley rats were randomized into six groups of equal size (n = 6/group): two control and four intervention groups: Positive control (C1) rats were not given any therapy, and comparative control (C2) rats were given topical hydrocortisone cream 2.5%. Subjects in the P1 group were given non-ozonated A. vera therapy, P2 group was given 300 mg/mL ozonated A. vera, P3 group was given 600 mg/mL ozonated A. vera, and P4 was given 1200 mg/mL ozonated A. vera therapy. Subject termination and histopathological analyses of vascular endothelial growth factor (VEGF) and microvascular density were carried out after 7 treatment days.

RESULTS: Based on Weidner microvascular density scoring system, the least microvascular density was observed in C2, P3, and P4 (2.0 ± 0.0), followed by P1 (2.1 ± 0.1), P2 (2.9 ± 1.5), and C1 (3.0 ± 0.7). Based on immunoreactive immunoreactive score (IRS) VEGF scoring system, the lowest expression of VEGF was observed in group P3 (4.1 ± 1.1), followed by P4 (4.3 ± 0.8), C2 (4.3 ± 1.3), P1 (5.1 ± 1.0), P2 (5.4 ± 0.6), and C1 (6.5 ±1.0). There was a strong positive correlation of VEGF and microvascular density.

CONCLUSION: Topical application of ozonated A. vera to the radiated skin of Sprague Dawley rats reduced VEGF expression and microvascular density. This anti-inflammatory effect may suggest its potential clinical application.
Comparison of V Technique and Femoral Arterial Palpation Techniques Accuracy in Identifying the Femoral Vein’s Cannulation Site
Authors: Tantri Aida Rosita , Alatas Anas , Dharma Reza Surya 
Published: March 2022

BACKGROUND: The femoral vein cannulation is essential for vascular access and finding it by just relying on the femoral artery pulsation can be challenging in a certain condition. V technique is a new technique to identify the femoral vein’s cannulation site based on topographic anatomy without relying on femoral artery pulsation.

AIM: This study was aimed to compare V technique and arterial palpation technique accuracies in identifying the femoral vein’s cannulation site.

METHODS: This study was a cross-sectional study on 115 adult patients aged 18–65 years old with body mass index 18–25 kg/m2 who underwent elective surgery in Cipto Mangunkusumo National General Hospital on February-March 2020. After ethical approval and informed consent, the distance of the femoral vein’s cannulation site identified by both techniques with the skin projection of the femoral vein diameter identified by ultrasonography (USG) were compared in all subjects. Accuracy was defined when the femoral vein’s cannulation sites identified by both techniques were within the skin projection of femoral vein diameter identified by USG. Data were collected and analyzed using SPSS ver 20.

RESULTS: The accuracy of the V technique in determining the femoral vein’s cannulation site was 93.9%, while the accuration of the femoral artery pulsation technique was 96.5%. Mcnemar analysis showed no difference in both techniques’ accuracy (p = 0.549). There was a statistically significant positive correlation between the distance of the femoral vein cannulation site predicted by both techniques with the skin projection of the femoral vein midpoint (r = 0.548; p < 0.001).

CONCLUSION: V technique’s accuracy was not significantly different from the femoral artery pulsation palpation technique’s accuracy in identifying the femoral vein cannulation site.
IL-27 Enhances γδ T Cell–Mediated Innate Resistance to Primary Hookworm Infection in the Lungs
Authors: Sharma Arjun , Noon Jason B , Kontodimas Konstantinos , Garo Lucien P , Platten Johannes , Quinton Lee J , Urban Joseph F , Reinhardt Christoph , Bosmann Markus 
Published: March 2022

Abstract
IL-27 is a heterodimeric IL-12 family cytokine formed by noncovalent association of the promiscuous EBI3 subunit and selective p28 subunit. IL-27 is produced by mononuclear phagocytes and unfolds pleiotropic immune-modulatory functions through ligation to IL-27 receptor α (IL-27RA). Although IL-27 is known to contribute to immunity and to limit inflammation after various infections, its relevance for host defense against multicellular parasites is still poorly defined. Here, we investigated the role of IL-27 during infection with the soil-transmitted hookworm, Nippostrongylus brasiliensis, in its early host intrapulmonary life cycle. IL-27(p28) was detectable in bronchoalveolar lavage fluid of C57BL/6J wild-type mice on day 1 after s.c. inoculation. IL-27RA expression was most abundant on lung-invading γδ T cells. Il27ra−/− mice showed increased lung parasite burden together with aggravated pulmonary hemorrhage and higher alveolar total protein leakage as a surrogate for epithelial–vascular barrier disruption. Conversely, injections of recombinant mouse (rm)IL-27 into wild-type mice reduced lung injury and parasite burden. In multiplex screens, higher airway accumulations of IL-6, TNF-α, and MCP-3 (CCL7) were observed in Il27ra−/− mice, whereas rmIL-27 treatment showed a reciprocal effect. Importantly, γδ T cell numbers in airways were enhanced by endogenous or administered IL-27. Further analysis revealed a direct antihelminthic function of IL-27 on γδ T cells as adoptive intratracheal transfer of rmIL-27–treated γδ T cells during primary N. brasiliensis lung infection conferred protection in mice. In summary, this report demonstrates protective functions of IL-27 to control the early lung larval stage of hookworm infection.
Patients with Chronic Kidney Disease Have Higher Acute Kidney Injury Morbidity than those Without After SARS-CoV-2 Infection
Authors: Song Yuting , Mao Dongdong , Zou Rong , Hu Yanglin , Luo Dan , Liu Hong , Tu Can , Xiong Fei 
Published: March 2022

Abstract

Background and Objectives:
Chronic kidney disease (CKD) and acute kidney injury (AKI) increase the risk of serious disease and mortality in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-infected patients. This study evaluated the occurrence and outcome of AKI in CKD and non-CKD patients infected with SARS-CoV-2.

Subjects and Methods:
We retrospectively analyzed the medical records of 845 patients with SARS-CoV-2 infection regarding the occurrence and outcome of AKI in a coronavirus disease-2019 (COVID-19)-designated hospital in Wuhan, China, from December 31, 2019, to March 20, 2020.

Results:
Of the 845 COVID-19 patients, 91 had CKD and 754 had no CKD (non-CKD), of whom 22 and 14 developed AKI, respectively. Finally, 36 patients were included in the analysis. Older patients and those with cardiovascular or cerebrovascular diseases were more likely to develop AKI. More CKD patients progressed to critical illness (72.73%) than non-CKD patients (57.14%), but the degree of AKI in CKD patients was lesser than that in non-CKD patients. Higher urea nitrogen, creatinine, and proteinuria levels were observed in CKD patients. More non-CKD patients were treated with human albumin than CKD patients. The survival probability of CKD patients was lower than that of non-CKD patients, but it was not statistically significant.

Conclusion:
There were significant differences in the incidence rate of AKI after SARS-CoV-2 infection between CKD and non-CKD patients, and the clinical manifestations and treatments of AKI also differed. These results highlight the necessity of variable treatment methods for optimal clinical management.