bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevated plasma WIF‐1 levels are associated with worse prognosis in heart failure with pulmonary hypertension
Authors: Kania Kriss , Ahmed Abdulla , Ahmed Salaheldin , Rådegran Göran 
Published: September 2022

AbstractAimsHeart failure (HF) is a progressive condition that is becoming more prevalent in the ageing population. Pulmonary hypertension is a common complicating factor in HF and negatively impacts survival. Plasma biomarkers are a potential method for determining the prognosis of patients with left heart failure with pulmonary hypertension (LHF‐PH). We aimed to analyse the prognostic capability of 33 proteins related to, among other pathways, inflammation, coagulation, and Wnt signalling in LHF‐PH.MethodsPlasma levels of 33 proteins were analysed using proximity extension assay from the plasma of 20 controls and 67 LHF‐PH patients, whereof 19 underwent heart transplantation (HT). Haemodynamics in the patients were assessed using right heart catheterization.ResultsEleven proteins had elevated plasma levels in LHF‐PH compared with controls (P < 0.01), which decreased towards the controls' levels after HT (P < 0.01). Survival analysis of these proteins showed that elevated plasma levels of growth hormone, programmed cell death 1 ligand 2, tissue factor pathway inhibitor 2, and Wnt inhibitory factor 1 (WIF‐1) were associated with worse transplantation‐free survival in LHF‐PH (P < 0.05). When adjusted for age, sex and N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) levels using multivariable cox regressions, only WIF‐1 remained prognostic [hazard ratio (95% confidence interval)] [1.013 (1.001–1.024)]. WIF‐1 levels in LHF‐PH patients also correlated with the mean right atrial pressure (rs = 0.42; P < 0.01), stroke volume index (rs = 0.41; P < 0.01), cardiac index (rs = −0.42; P < 0.01), left ventricular stroke work index (rs = −0.41; P < 0.01), and NT‐proBNP (rs = 0.63; P < 0.01).ConclusionsThe present study demonstrated that LHF‐PH patients have higher plasma WIF‐1 levels than healthy controls, suggesting that plasma WIF‐1 may be a potential future prognostic biomarker in LHF‐PH. Its prognostic capability could be further refined by including it in a multi‐marker panel. Further studies are needed to establish the potential role of WIF‐1 in LHF‐PH pathophysiology in larger cohorts to determine its clinical applicability.
Ligand‐Free Pd‐Catalyzed Reductive Mizoroki‐Heck Reaction Strategy for the One‐Pot Synthesis of Functionalized Oxygen Heterocycles in Deep Eutectic Solvents
Authors: Dilauro Giuseppe , Cicco Luciana , Vitale Paola , Perna Filippo Maria , Capriati Vito 
Published: September 2022

AbstractA Deep Eutectic Solvent, choline chloride/glycerol (1 : 2 mol mol−1), proved to be an effective and sustainable reaction medium to promote telescoped, one‐pot Mizoroki‐Heck cross‐coupling/reduction processes between 2,3‐dihydrofuran or 3,4‐dihydro‐2H‐pyran and several (hetero)aryl halides to easily access valuable 2‐(hetero)aryl tetrahydrofuran (THF) or tetrahydropyran derivatives in up to 95 % yield. Notably, the whole transformation takes place under aerobic conditions, in the absence of additional ligands, and with a good substrate scope. The practicability of the method is also exemplified by the sustainable synthesis of two key THF derivatives, which are side chains of pharmacologically relevant inhibitors of Kv1.2 channel.
Aluminium‐Catalyzed Selective Reduction of Heteroallenes Through Hydroboration: Amide/Thioamide/Selenoamide Bond Construction and C=X (X=O, S, Se) Bond Activation**
Authors: Sarkar Nabin , Sahoo Rajata Kumar , Nembenna Sharanappa 
Published: September 2022

AbstractAn unprecedented conjugated bis‐guanidinate (CBG) stabilized aluminium dihydride, [LAlH2; (L={(ArNH)(ArN)−C=N−C=(NAr)(NHAr)}; Ar=2,6‐Et2‐C6H3)] (I) catalyzed chemoselective hydroboration of heteroallenes such as carbodiimide (CDI)s, isocyanates, isothiocyanates, and isoselenocyanates is reported. A wide range of heteroallenes, including electron‐donating and withdrawing groups, experience hydroboration to obtain selectively N‐boryl amide, N‐borylaminal, and N‐boryl methyl amine products. More importantly, a single sustainable molecular aluminium‐based catalyst effectively catalyzes CDIs, isocyanates, isothiocyanates, and isoselenocyanates into formamidines, formamides, thioformamides, and selenoformamides, respectively. Further, heteroallene substrates undergo hydrodeoxygenation (HDO), hydrodesulfurization (HDS), and hydrodeselenization (HDSe) reactions leading to N‐boryl methyl amines. In addition, a series of control and kinetic experiments indicate that the aluminium hydride species are essential for all partial and complete reduction steps and breaking the C=X (X=O, S, and Se) bonds in heteroallenes.
Evaluating the challenges to Life Cycle Assessment using Best‐Worst Method and Decision‐Making Trial and Evaluation Laboratory
Authors: Karuppiah Koppiahraj , Sankaranarayanan Bathrinath , Ali Syed Mithun 
Published: September 2022

AbstractPurposeOver the past few decades, the industrial sectors have been widely criticized for their adverse environmental impacts and uncontrolled resources consumption. Further, stringent environmental norms and growing environmental awareness has pushed industrial sectors to adopt sustainable industrial practice. Life Cycle Assessment (LCA), an industrial performance assessment tool, has several limitations and hence, it is difficult to measure the performance of industrial sectors in terms of sustainability. The present study aims to identify and evaluate the challenges to LCA.MethodsCombining literature review and industrial interactions has identified 20 challenges to LCA under five‐category comparability, data, resource requirements, organizational structure, and uncertainty communication. An integrated Multi‐Criteria Decision Making (MCDM) technique comprising of Best‐Worst Method (BWM) and Decision‐Making Trial and Evaluation of Laboratory (DEMATEL) is used to evaluate the challenges to LCA. BWM is used to prioritize the challenges to LCA, and DEMATEL is used to reveal interrelationships among the challenges.ResultsOutcomes of BWM indicates problems with the quality of data, lack of inventory data, difficulty in comparison, absence of dedicated LCA method, and scale‐up issues as the top five critical challenges to LCA adoption. According to DEMATEL result, seven challenges come under cause category and the remaining 13 challenges come under effect category.ConclusionsChallenges to LCA have been evaluated using an integrated approach comprising of BWM‐DEMATEL. Outcome of the integrated approach helps in prioritizing the challenges and also in exposing the interrelationships among the challenges. The study's outcome would assist industrial management and practitioners in identifying the critical challenges to LCA. In addition, the findings may help the research community in developing a robust and reliable LCA tools.
Punica granatum peel supplementation attenuates cognitive deficits and brain injury in rat by targeting the Nrf2‐HO‐1 pathway
Authors: Akbarian Mahsan , Hosseini Mahmoud , Mirzavi Farshad , Amirahmadi Sabiheh , Arab Fahimeh Lavi , Rajabian Arezoo 
Published: September 2022

AbstractThe critical role of nutrition to prevent neurodegenerative disorders is well documented. Punica granatum fruit is identified as a highly nutritional food for alleviating various ailments. The ameliorating properties of P. granatum peel on memory dysfunction and the possible roles of oxidative stress, acetylcholinesterase (AchE), and nuclear factor erythroid 2‐related factor 2 (Nrf2)‐heme oxygenase (HO)‐1 pathway in the scopolamine‐treated rats were assessed. The hydroethanolic extract was standardized using high‐performance liquid chromatography (HPLC). The animal groups were as follows: Control, scopolamine (2 mg/kg), and treatment groups (the extract at doses of 200–800 mg/kg). The behavioral performance was evaluated using the Morris water maze (MWM) and passive avoidance equipment. Various biochemical parameters were then measured. Rats received the extract properly found on the platform location, indicated by a shorter traveling time and distance during 5 days of learning MWM. Moreover, the extract increased the delay and light time, while decreasing dark time and the frequency of entries to the dark in the passive avoidance test. The extract also exerted a significant increase in superoxide dismutase activity and thiol content, while decreasing AchE activity and lipid peroxidation in the brain of scopolamine‐injured rats. Our results demonstrated the neuroprotective effects of P. granatum peel in minimizing scopolamine injury possibly through targeting the Nrf2‐HO‐1 pathway.
Industry variance risk premium, cross‐industry correlation, and expected returns
Authors: Zhu Yabei , Luo Xingguo , Xu Qi 
Published: September 2022

AbstractWe investigate the variance risk premium (VRP) and implied correlation (IC) at the industry level. Using the index and sector exchange‐traded fund options, we construct‐sector VRPs and cross‐sector IC measures. Sector VRPs predict sector returns, and adding the average sector VRP with IC improves predictability. Combining the average sector VRP and IC outperforms the market VRP in predicting market returns both in‐sample and out‐of‐sample and generates sizeable economic values. We document a strong spillover effect from sector VRPs to the market VRP. The average sector VRP and cross‐sector IC contain information beyond the market VRP and cross‐stock IC.
Brain age vector: A measure of brain aging with enhanced neurodegenerative disorder specificity
Authors: Ran Chen , Yang Yanwu , Ye Chenfei , Lv Haiyan , Ma Ting 
Published: September 2022

AbstractNeuroimaging‐driven brain age estimation has become popular in measuring brain aging and identifying neurodegenerations. However, the single estimated brain age (gap) compromises regional variations of brain aging, losing spatial specificity across diseases which is valuable for early screening. In this study, we combined brain age modeling with Shapley Additive Explanations to measure brain aging as a feature contribution vector underlying spatial pathological aging mechanism. Specifically, we regressed age with volumetric brain features using machine learning to construct the brain age model, and model‐agnostic Shapley values were calculated to attribute regional brain aging for each subject's age estimation, forming the brain age vector. Spatial specificity of the brain age vector was evaluated among groups of normal aging, prodromal Parkinson disease (PD), stable mild cognitive impairment (sMCI), and progressive mild cognitive impairment (pMCI). Machine learning methods were adopted to examine the discriminability of the brain age vector in early disease screening, compared with the other two brain aging metrics (single brain age gap, regional brain age gaps) and brain volumes. Results showed that the proposed brain age vector accurately reflected disorder‐specific abnormal aging patterns related to the medial temporal and the striatum for prodromal AD (sMCI vs. pMCI) and PD (healthy controls [HC] vs. prodromal PD), respectively, and demonstrated outstanding performance in early disease screening, with area under the curves of 83.39% and 72.28% in detecting pMCI and prodromal PD, respectively. In conclusion, the proposed brain age vector effectively improves spatial specificity of brain aging measurement and enables individual screening of neurodegenerative diseases.
A scoping review of statistical methods for trial‐based economic evaluations: The current state of play
Authors: El Alili Mohamed , van Dongen Johanna M. , Esser Jonas L. , Heymans Martijn W. , van Tulder Maurits W. , Bosmans Judith E. 
Published: September 2022

AbstractThe statistical quality of trial‐based economic evaluations is often suboptimal, while a comprehensive overview of available statistical methods is lacking. Therefore, this review summarized and critically appraised available statistical methods for trial‐based economic evaluations. A literature search was performed to identify studies on statistical methods for dealing with baseline imbalances, skewed costs and/or effects, correlated costs and effects, clustered data, longitudinal data, missing data and censoring in trial‐based economic evaluations. Data was extracted on the statistical methods described, their advantages, disadvantages, relative performance and recommendations of the study. Sixty‐eight studies were included. Of them, 27 (40%) assessed methods for baseline imbalances, 39 (57%) assessed methods for skewed costs and/or effects, 27 (40%) assessed methods for correlated costs and effects, 18 (26%) assessed methods for clustered data, 7 (10%) assessed methods for longitudinal data, 26 (38%) assessed methods for missing data and 10 (15%) assessed methods for censoring. All identified methods were narratively described. This review provides a comprehensive overview of available statistical methods for dealing with the most common statistical complexities in trial‐based economic evaluations. Herewith, it can provide valuable input for researchers when deciding which statistical methods to use in a trial‐based economic evaluation.
Efficacy and safety of fecal microbiota transplant in irritable bowel syndrome: An update based on meta‐analysis of randomized control trials
Authors: Abdelghafar Yomna Ali , AbdelQadir Yossef Hassan , Motawea Karam R. , Nasr Sara Amr , Omran Hoda Aly Mohamed , Belal Mohamed Mohamed , Elhashash Mohamed Mahdy , AbdelAzim Ahmed Alaa , Shah Jaffer 
Published: September 2022

AbstractBackground and AimsFecal microbiota transfer (FMT) is a potential treatment for irritable bowel syndrome (IBS). Several randomized trials have tested FMT effects using different routes of administration, doses, and sample sizes. We aim to assess the overall efficacy of FMT for IBS patients and the safety of the intervention.MethodsWe systematically searched four databases for randomized control trials that studied the efficacy and safety of FMT in IBS patients.ResultsWe included 8 randomized trials (472 patients) that compared FMT with placebo in IBS patients. Pooled results showed no statistically significant difference between FMT and control groups in the overall change in IBS symptom severity (IBS‐SSS) at 1 month (p = 0.94), 3/4 months (p = 0.82), and at the end of trials (p = 0.67). No significant difference in the total number of respondents between the FMT and control groups (risk ratios = 1.84, [95% confidence interval (CI) = 0.82–2.65], p = 0.19). Although the oral route of administration showed a significant difference in the number of respondents (p = 0.004), there was no statistically significant difference in the IBS‐SSS when subgrouping the oral route of administration (mean difference = 47.57, [95% CI = −8.74–103.87], p = 0.10).ConclusionFMT is not an effective treatment to relieve all the symptoms of IBS. Even in the groups that showed relatively significant improvement after FMT, the effect was proven to wear off over time and the re‐administration carries a low success rate. Future research should consider different bacterial‐based interventions such as probiotics or specific antibiotics.
Ultra‐processed food consumption and the risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Authors: Zhong Guo‐Chao , Zhu Qian , Cai Dong , Hu Jie‐Jun , Dai Xin , Gong Jian‐Ping , Sun Wei‐Ping 
Published: September 2022

AbstractWhether ultra‐processed food consumption is associated with the risk of pancreatic cancer has not been determined. We performed a prospective study to fill this gap. A population‐based cohort of 98 265 American adults was identified from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Ultra‐processed foods were defined by the NOVA classification. Cox regression was used to estimate hazard ratios (HRs) for pancreatic cancer incidence. Subgroup analysis was performed to identify the potential effect modifiers. During a mean follow‐up of 8.86 years, 387 pancreatic cancer cases occurred. High consumption of ultra‐processed foods was found to be associated with an increased risk of pancreatic cancer (fully adjusted HRquartile 4 vs 1:1.49; 95% confidence interval [CI]: 1.07‐2.07; Ptrend = .021) in a linear dose‐response manner (Pnonlinearity = .075). Subgroup analysis further found that the positive association of ultra‐processed food consumption with the risk of pancreatic cancer was more pronounced in subjects aged <65 years (HRquartile 4 vs 1:2.17; 95% CI: 1.14‐4.15) than in those aged ≥65 years (HRquartile 4 vs 1:1.32; 95% CI: 0.88‐1.94), though the interaction test failed to achieve the statistical significance (Pinteraction = .061). These findings suggest that reducing ultra‐processed food consumption may be beneficial in decreasing pancreatic cancer incidence.
Identifying risk factors for placental abruption in subsequent pregnancy without a history of placental abruption
Authors: Goldbart Adi , Pariente Gali , Sheiner Eyal , Wainstock Tamar 
Published: September 2022

AbstractObjectiveTo identify first pregnancy risk factors for placental abruption in subsequent pregnancy.MethodsIn a population‐based nested case–control study, cases were defined as women with placental abruption in their second pregnancy, and controls as women without abruption. A total of 43 328 women were included in the study, 0.4% (n = 186) of second pregnancies had placental abruption. Multivariable logistic models were used to study the association between first pregnancy complications and placental abruption in subsequent pregnancy.ResultsHaving either small for gestational age, preterm delivery, pre‐eclampsia or cesarean delivery during first pregnancy were independently associated with increased risk for placental abruption, and the risk was higher with any additional complication (age adjusted odds ratio [aOR] 2.00, 95% confidence interval [CI] 1.46–2.74; aOR 3.61, 95% CI 2.23–5.86; and aOR 3.86, 95% CI 1.56–9.56, for one, two, and three or more complications, respectively).ConclusionFirst pregnancy may serve as a window of opportunity to identify women at risk for future placental abruption.
School‐based interventions to improve emotional regulation skills in adolescent students: A systematic review
Authors: Pedrini Laura , Meloni Serena , Lanfredi Mariangela , Rossi Roberta 
Published: September 2022

AbstractIntroductionEmotional regulation (ER) is a core variable involved in the onset and maintenance of mental health disorders; therefore, interventions targeting ER in adolescence represent a promising preventive action. The current systematic review provides a synthesis of the evidence on school‐based interventions on ER in adolescent students.MethodsSix electronic databases (Medline, Psychology Database, Embase, Scopus, Psychinfo, and Web of Science) were searched. The methodological quality of the included studies was assessed by the Methodological Index for Nonrandomized Studies.ResultsA total of 36 studies were identified. The interventions were based on different theoretic frameworks and focused on different components of ER. There were universal interventions that addressed the entire class, as well as interventions for a selected population of at‐risk students. Only one‐third of the studies were based on manualized programs. Small to moderate effect sizes were found for mental health and ER skills. Only a few studies assessed risky behaviors, and these studies showed a reduction with moderate to large effect size. Studies conducted on high‐risk populations showed medium‐high effect sizes on ER skills. In contrast, studies conducted on unselected samples of students showed greater variability in the outcome estimates. Acceptability analysis and attendance rates suggested that the interventions were well received by students. The lack of follow‐up assessments and the absence of sample‐size calculation were the most frequent methodological weaknesses.ConclusionsThe content of the present review could be useful for professionals involved in the planning of school psychological services. Overall, the findings of the current review support the applicability and beneficial effect of school‐based intervention for adolescents. Moreover, the results clearly point out the utility of a multitiered model to structure coordinated and integrated preventive interventions and to optimize resources.
Long-Term Selenium-Yeast Supplementation Does Not Affect Bone Turnover Markers: A Randomized Placebo-Controlled Trial
Authors: Perri Giorgia , Hill Tom R , Mathers John C , Walsh Jennifer S , Gossiel Fatma , Winther Kristian , Frölich Jacob , Folkestad Lars , Cold Søren , Eastell Richard 
Published: September 2022

ABSTRACT
Higher selenium status has been associated with lower bone turnover markers (BTM) in epidemiological studies. However, the long-term impact of selenium supplementation on BTMs has not been studied. We investigated the effects of selenium supplementation on BTMs including osteocalcin (OC), procollagen type I N-terminal propeptide (PINP), collagen type I cross-linked C-telopeptide (CTX), and bone alkaline phosphatase (BALP) in the short (6 months) and long term (5 years). A total of 481 Danish men and women (60–74 years) were randomized to receive placebo-yeast versus 100, 200, or 300 μg selenium as selenium-enriched yeast daily for 5 years. Plasma selenium concentration was measured using inductively coupled plasma mass spectrometry, and BTMs were measured in nonfasted samples at baseline, 6 months, and 5 years. Data were analyzed by ANCOVA to investigate the shape of the dose-response relationships. Covariates included age, body mass index, baseline selenium status, baseline BTM, smoking, alcohol, supplement use, and medication. Plasma selenium concentration (mean 86.5 μg/d at baseline) increased significantly with increasing selenium supplementation to 152.6, 209.1, and 253.7 μg/L after 6 months and remained elevated at 5 years (158.4, 222.4, and 275.9 μg/L for 100, 200, and 300 μg supplemental selenium/d, respectively (p &lt; 0.001)). There was no change in plasma selenium concentration in the placebo-treated group. There was no significant effect of selenium supplementation on OC (6 months p = 0.37; 5 years p = 0.63), PINP (6 months p = 0.37; 5 years p = 0.79), CTX (6 months p = 0.91; 5 years p = 0.58) or BALP (6 months p = 0.17; 5 years p = 0.53). The relatively replete baseline selenium status in the study participants may explain this lack of effect. Testing in more deficient populations may provide further insights into the impact of selenium supplementation on bone health. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).