bluuebunny/crossref_metadata_2025_split huggingface dataset:
A quantitative study on the impact of working environment on the well-being of teachers in China’s private colleges
Authors: Chen Jinping , Cheng Hongyan , Zhao Dan , Zhou Fuyu , Chen Yuan 
Published: March 2022

AbstractTeacher well-being is a prominent issue in policy and public debates. Those teachers working in private schools deserve concern given concerns about their working environment. Focus of this study: to learn about the level and main characteristics of teacher well-being in private schools and to explore the impact of working environment on their well-being. Methodology: The data were collected via an online questionnaire among 1161 language teachers at 58 China’s private colleges in 22 provinces, and were quantitatively analyzed with SPSS 23.0. Findings: These teachers have an intermediate level of overall well-being. Performance evaluation, student academic foundation, and pressure of research work are the main negative impacting factors; while social support from leaders and colleagues, work autonomy, training and development opportunities, and appraisal feedback guide are key resources enhancing their well-being. Discussions: The impacting factors of working environment on teacher well-being in private schools are unique due to the special scenarios. Implications: The results of this study may apply to similar private schools, suggesting pertinent stakeholders to take targeted measures, to guarantee enough economic input into running school, and to put democratic and professional leadership into practice for promoting teacher well-being in the private education sector.
DNA repair phenotype and cancer risk: a systematic review and meta-analysis of 55 case–control studies
Authors: Wu Hui-Chen , Kehm Rebecca , Santella Regina M. , Brenner David J. , Terry Mary Beth 
Published: March 2022

AbstractDNA repair phenotype can be measured in blood and may be a potential biomarker of cancer risk. We conducted a systematic review and meta-analysis of epidemiological studies of DNA repair phenotype and cancer through March 2021. We used random-effects models to calculate pooled odds ratios (ORs) of cancer risk for those with the lowest DNA repair capacity compared with those with the highest capacity. We included 55 case–control studies that evaluated 12 different cancers using 10 different DNA repair assays. The pooled OR of cancer risk (all cancer types combined) was 2.92 (95% Confidence Interval (CI) 2.49, 3.43) for the lowest DNA repair. Lower DNA repair was associated with all studied cancer types, and pooled ORs (95% CI) ranged from 2.02 (1.43, 2.85) for skin cancer to 7.60 (3.26, 17.72) for liver cancer. All assays, except the homologous recombination repair assay, showed statistically significant associations with cancer. The effect size ranged from 1.90 (1.00, 3.60) for the etoposide-induced double-strand break assay to 5.06 (3.67, 6.99) for the γ-H2AX assay. The consistency and strength of the associations support the use of these phenotypic biomarkers; however large-scale prospective studies will be important for understanding their use related to age and screening initiation.
Preterm birth buccal cell epigenetic biomarkers to facilitate preventative medicine
Authors: Winchester Paul , Nilsson Eric , Beck Daniel , Skinner Michael K. 
Published: March 2022

AbstractPreterm birth is the major cause of newborn and infant mortality affecting nearly one in every ten live births. The current study was designed to develop an epigenetic biomarker for susceptibility of preterm birth using buccal cells from the mother, father, and child (triads). An epigenome-wide association study (EWAS) was used to identify differential DNA methylation regions (DMRs) using a comparison of control term birth versus preterm birth triads. Epigenetic DMR associations with preterm birth were identified for both the mother and father that were distinct and suggest potential epigenetic contributions from both parents. The mother (165 DMRs) and female child (136 DMRs) at p < 1e−04 had the highest number of DMRs and were highly similar suggesting potential epigenetic inheritance of the epimutations. The male child had negligible DMR associations. The DMR associated genes for each group involve previously identified preterm birth associated genes. Observations identify a potential paternal germline contribution for preterm birth and identify the potential epigenetic inheritance of preterm birth susceptibility for the female child later in life. Although expanded clinical trials and preconception trials are required to optimize the potential epigenetic biomarkers, such epigenetic biomarkers may allow preventative medicine strategies to reduce the incidence of preterm birth.
Initial measurement of ion nonextensive parameter with geodesic acoustic mode theory
Authors: Qiu Huibin , Xiao Donghua , Wu Junjie , Wu Shengfa , Zhong Chengjie , Li Xiaobin , Peng Xingkun , Yuan Youlong , Cai Qilong , Chang Jinming , Hu Tianyi , Hu Zuozhi , Zhu Yuqing 
Published: March 2022

AbstractThe consideration of nonextensivity effects is crucial to the accurate diagnosis of plasma parameters; common plasma nonextensive parameters include electron nonextensive parameter and ion nonextensive parameter, and the former can be measured, while the ion nonextensive parameter cannot be measured yet. Here we show the measurement of ion nonextensive parameter of plasma based on the theory of nonextensive geodesic acoustic modes. We assume that the plasma to be measured can be described by nonextensive statistical mechanics, and on this basis, the nonextensive geodesic acoustic mode theory is established. Utilizing this theory, we have measured the ion nonextensive parameter $${{q}_{{{F}_{\mathrm {i}}}}}= 1.565$$

q

F
i

=
1.565

which cannot be diagnosed even by a nonextensive single electric probe. Our research points out that the proposed measurement method of ion nonextensive parameter may play a role in plasma diagnosis and will help us to grasp the nonextensivity of plasma more precisely. We hope the proposed method of ion nonextensive parameter diagnosis based on the nonextensive geodesic acoustic mode theory can be the starting point of more complex ion nonextensive parameter diagnosis methods. In addition, the measurement of ion nonextensive parameter is closely related to the study of various plasma waves, instabilities, turbulence and abnormal transport, and a defined and quantitative test of nonextensive geodesic acoustic mode theory will bound up deeply with such developments.
GC–MS and molecular docking analyses of phytochemicals from the underutilized plant, Parkia timoriana revealed candidate anti-cancerous and anti-inflammatory agents
Authors: Ralte Laldinfeli , Khiangte Laldinliana , Thangjam Nurpen M. , Kumar Awadhesh , Singh Y. Tunginba 
Published: March 2022

AbstractPlants are excellent sources of functionally bioactive compounds and essential nutrients. The phytochemical constituents have enormous potential in treating both plant and human diseases. Parkia timoriana (Yongchak/Zawngtah), one of the most important underutilized plants popularly consumed in Manipur and Mizoram states of Northeastern region of India, is known for its ethnobotanical and ethnomedicinal values. A significant DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2’-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)), and Phosphomolybdate scavenging activity corresponding to high antioxidant potentials was shown by the extracts from different edible parts of P. timoriana. P. timoriana extract showed significant antibacterial potential against Bacillus pumilus, Bacillus subtillis, Escherichia coli and Pseudomonas aeruginosa. Fourier transform infrared spectroscopy and gas chromatography-mass spectrometry (GC–MS) analyses of the extracts revealed the functional groups and bioactive compounds present in different edible parts of the plant. Characteristic peaks of phenols, carboxylic acids, alkenes, glycogen, alkyl halides, halogen, aliphatic amines, primary and secondary amines, esters, ether, aromatics, lipids, triglycerides, nitro compounds that had antimicrobial, anti-cancer and anti-inflammatory properties etc. were observed. The GC–MS analysis also revealed the occurrence of 49 bioactive compounds that are known to possess a variety of pharmacological activities. Subsequently, in silico molecular docking studies of the identified bioactive compounds predicted potential anticancer and anti-inflammatory properties. To the best of our knowledge, this is the first-hand report on the bioactive compounds of edible parts of P. timoriana extracts showing antioxidant, antimicrobial and pharmacological significance. This study can lead to the production of new herbal medicines for various diseases employing P. timoriana and perhaps leading to the creation of new medications.
Transgenic manipulation of triacylglycerol biosynthetic enzymes in B. napus alters lipid-associated gene expression and lipid metabolism
Authors: Liao Pan , Lechon Tamara , Romsdahl Trevor , Woodfield Helen , Fenyk Stepan , Fawcett Tony , Wallington Emma , Bates Ruth E. , Chye Mee-Len , Chapman Kent D. , Harwood John L. , Scofield Simon 
Published: March 2022

AbstractOilseed rape (Brassica napus) is an important crop that is cultivated for the oil (mainly triacylglycerol; TAG) it produces in its seeds. TAG synthesis is controlled mainly by key enzymes in the Kennedy pathway, such as glycerol 3-phosphate acyltransferase (GPAT), lysophosphatidate acyltransferase (LPAT) and diacylglycerol acyltransferase (DGAT) but can also be produced from phosphoglycerides such as phosphatidylcholine (PC) by the activity of the enzyme phospholipid: diacylglycerol acyltransferase (PDAT). To evaluate the potential for these enzymes to alter oil yields or composition, we analysed transgenic B. napus lines which overexpressed GPAT, LPAT or PDAT using heterologous transgenes from Arabidopsis and Nasturtium and examined lipid profiles and changes in gene expression in these lines compared to WT. Distinct changes in PC and TAG abundance and spatial distribution in embryonic tissues were observed in some of the transgenic lines, together with altered expression of genes involved generally in acyl-lipid metabolism. Overall our results show that up-regulation of these key enzymes differentially affects lipid composition and distribution as well as lipid-associated gene expression, providing important information which could be used to improve crop properties by metabolic engineering.
Local genetic variation of inflammatory bowel disease in Basque population and its effect in risk prediction
Authors: Garcia-Etxebarria Koldo , Merino Olga , Gaite-Reguero Adrián , Rodrigues Pedro M. , Herrarte Amaia , Etxart Ane , Ellinghaus David , Alonso-Galan Horacio , Franke Andre , Marigorta Urko M. , Bujanda Luis , D’Amato Mauro 
Published: March 2022

AbstractInflammatory bowel disease (IBD) is characterised by chronic inflammation of the gastrointestinal tract. Although its aetiology remains unknown, environmental and genetic factors are involved in its development. Regarding genetics, more than 200 loci have been associated with IBD but the transferability of those signals to the Basque population living in Northern Spain, a population with distinctive genetic background, remains unknown. We have analysed 5,411,568 SNPs in 498 IBD cases and 935 controls from the Basque population. We found 33 suggestive loci (p < 5 × 10−6) in IBD and its subtypes, namely Crohn’s Disease (CD) and Ulcerative Colitis (UC), detecting a genome-wide significant locus located in HLA region in patients with UC. Those loci contain previously associated genes with IBD (IL23R, JAK2 or HLA genes) and new genes that could be involved in its development (AGT, BZW2 or FSTL1). The overall genetic correlation between European populations and Basque population was high in IBD and CD, while in UC was lower. Finally, the use of genetic risk scores based on previous GWAS findings reached area under the curves > 0.68. In conclusion, we report on the genetic architecture of IBD in the Basque population, and explore the performance of European-descent genetic risk scores in this population.
Using contact tracing from interlocking diaries to map mood contagion along network chains
Authors: Fu Yang-chih , Chan Ta-Chien , Chu Yen-Hua , Hwang Jing-Shiang 
Published: March 2022

AbstractBoth viruses and moods are transmitted through interpersonal contacts, but it has been extremely difficult to track each unique chain of contacts through which particular moods diffuse. By analyzing 56,060 contact records from 113 interlocking, yearlong diaries collected through a web-based platform in Taiwan, we traced mood states before and after each specific contact along a triplet of persons where B contacts C and subsequently contacts A. Multilevel analyses show that both positive and negative emotions are contagious, but the two paths diverge markedly in how the diffusion stops. Positive contact between C and B (which leads to improved mood for B) spreads to A through B’s contact with A, making A feel better afterward, regardless of whether B’s mood deteriorated between the two interactions. Negative contact between C and B (which leads to worsened mood for B) also spreads to A, making A feel worse after the contact with B. However, the spread of a negative mood discontinues if B’s mood improved between the two contacts. The different patterns of diffusion suggest that a negative mood is harder to disperse, probably because people generally make efforts to keep their negative emotions from spreading to others.
Structural and functional characterization of an achromatopsia-associated mutation in a phototransduction channel
Authors: Zheng Xiangdong , Li Huan , Hu Zhengshan , Su Deyuan , Yang Jian 
Published: March 2022

AbstractNumerous missense mutations in cyclic nucleotide-gated (CNG) channels cause achromatopsia and retinitis pigmentosa, but the underlying pathogenic mechanisms are often unclear. We investigated the structural basis and molecular/cellular effects of R410W, an achromatopsia-associated, presumed loss-of-function mutation in human CNGA3. Cryo-EM structures of the Caenorhabditis elegans TAX-4 CNG channel carrying the analogous mutation, R421W, show that most apo channels are open. R421, located in the gating ring, interacts with the S4 segment in the closed state. R421W disrupts this interaction, destabilizes the closed state, and stabilizes the open state. CNGA3_R410W/CNGB3 and TAX4_R421W channels are spontaneously active without cGMP and induce cell death, suggesting cone degeneration triggered by spontaneous CNG channel activity as a possible cause of achromatopsia. Our study sheds new light on CNG channel allosteric gating, provides an impetus for a reevaluation of reported loss-of-function CNG channel missense disease mutations, and has implications for mutation-specific treatment of retinopathy.
Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides
Authors: Bost Jeremy P. , Ojansivu Miina , Munson Michael J. , Wesén Emelie , Gallud Audrey , Gupta Dhanu , Gustafsson Oskar , Saher Osama , Rädler Julia , Higgins Stuart G. , Lehto Taavi , Holme Margaret N. , Dahlén Anders , Engkvist Ola , Strömstedt Per-Erik , Andersson Shalini , Edvard Smith C. I. , Stevens Molly M. , Esbjörner Elin K. , Collén Anna , El Andaloussi Samir 
Published: March 2022

AbstractThe therapeutic and research potentials of oligonucleotides (ONs) have been hampered in part by their inability to effectively escape endosomal compartments to reach their cytosolic and nuclear targets. Splice-switching ONs (SSOs) can be used with endosomolytic small molecule compounds to increase functional delivery. So far, development of these compounds has been hindered by a lack of high-resolution methods that can correlate SSO trafficking with SSO activity. Here we present in-depth characterization of two novel endosomolytic compounds by using a combination of microscopic and functional assays with high spatiotemporal resolution. This system allows the visualization of SSO trafficking, evaluation of endosomal membrane rupture, and quantitates SSO functional activity on a protein level in the presence of endosomolytic compounds. We confirm that the leakage of SSO into the cytosol occurs in parallel with the physical engorgement of LAMP1-positive late endosomes and lysosomes. We conclude that the new compounds interfere with SSO trafficking to the LAMP1-positive endosomal compartments while inducing endosomal membrane rupture and concurrent ON escape into the cytosol. The efficacy of these compounds advocates their use as novel, potent, and quick-acting transfection reagents for antisense ONs.
Nationwide increases in anti-SARS-CoV-2 IgG antibodies between October 2020 and March 2021 in the unvaccinated Czech population
Authors: Piler Pavel , Thon Vojtěch , Andrýsková Lenka , Doležel Kamil , Kostka David , Pavlík Tomáš , Dušek Ladislav , Pikhart Hynek , Bobák Martin , Matic Srdan , Klánová Jana 
Published: March 2022

Abstract
Background
The aim of the nationwide prospective seroconversion (PROSECO) study was to investigate the dynamics of anti-SARS-CoV-2 IgG antibodies in the Czech population. Here we report on baseline prevalence from that study.

Methods
The study included the first 30,054 persons who provided a blood sample between October 2020 and March 2021. Seroprevalence was compared between calendar periods, previous RT-PCR results and other factors.

Results
The data show a large increase in seropositivity over time, from 28% in October/November 2020 to 43% in December 2020/January 2021 to 51% in February/March 2021. These trends were consistent with government data on cumulative viral antigenic prevalence in the population captured by PCR testing – although the seroprevalence rates established in this study were considerably higher. There were only minor differences in seropositivity between sexes, age groups and BMI categories, and results were similar between test providing laboratories. Seropositivity was substantially higher among persons with history of symptoms (76% vs. 34%). At least one third of all seropositive participants had no history of symptoms, and 28% of participants with antibodies against SARS-CoV-2 never underwent PCR testing.

Conclusions
Our data confirm the rapidly increasing prevalence in the Czech population during the rising pandemic wave prior to the beginning of vaccination. The difference between our results on seroprevalence and PCR testing suggests that antibody response provides a better marker of past infection than the routine testing program.
Roughening the surface of porous NiCoP rod-like arrays via the in situ growth of NiCoP4O12 nanoislands enables highly efficient energy storage
Authors: Cui Mengqi , Jiang Yuanye , Wang Zhihao , Wang Xuyun , Wang Hui , Wang Rongfang 
Published: March 2022

Hollow NiCoP nanowire arrays were prepared by vapor deposition method, and then rough NiCoP4O12 nanoparticles were prepared by heat treatment, which exhibited excellent specific capacitance and high energy density and power density.
Can Dynamic Assessment Identify Language Disorder in Multilingual Children? Clinical Applications From a Systematic Review
Authors: Hunt Emily , Nang Charn , Meldrum Suzanne , Armstrong Elizabeth 
Published: March 2022

Purpose:
Multilingual children are disproportionately represented on speech pathology caseloads, in part due to the limited ability of traditional language assessments to accurately capture multilingual children's language abilities. This systematic review evaluates the evidence for identification of language disorder in multilingual children using dynamic assessment and considers clinical applications of the evidence.

Method:
A systematic search of the Cumulative Index to Nursing and Allied Health Literature, Education Resources Information Centre, Education Source, Google Scholar, Linguistics, Medline, and PsycINFO databases produced 10 articles that met the inclusion criteria: between-groups comparison studies that used dynamic assessment to identify language disorder in children under 12 years old that spoke a different language at home to the majority society language. Articles were critically appraised using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) protocol.

Results:
Nine of the 10 studies reported that their dynamic assessment identified language disorder in multilingual children. However, small sample sizes, limited language pairs, variability in the reference standard, and design deficiencies resulted in poor ratings for all studies on QUADAS-2.

Conclusions:
The studies in this review reflected an emergent area of research. Preliminary guidelines for clinical application indicate that dynamic assessment may be a suitable and time-efficient complementary method of diagnosis of language disorder in multilingual children. Further recommendations about age of use, language of instruction, and relevant scores are included.
A comprehensive review on the users’ identity privacy for 5G networks
Authors: Saeed Mamoon M. , Hasan Mohammad Kamrul , Obaid Ahmed J. , Saeed Rashid A. , Mokhtar Rania A. , Ali Elmustafa Sayed , Akhtaruzzaman Md , Amanlou Sanaz , Hossain A. K. M. Zakir 
Published: March 2022

AbstractFifth Generation (5G) is the final generation in mobile communications, with minimum latency, high data throughput, and extra coverage. The 5G network must guarantee very good security and privacy levels for all users for these features. Therefore, researchers have deliberated the privacy and security solution of 5G users. The 5G wireless network offers a futuristic concept that helps to solve challenges affecting previous communications generations. The key concern to many scholars in the field of mobile networking is user privacy, which is long‐term subscription identifier as International Mobiles Subscribers Identifiers (IMSIs) and short‐term subscription identifier as Temporary Mobiles Subscribers Identifiers and Cell‐Radio Networks Temporary Identifiers (TMSIs and C‐RNTIs), which are used for permanent identifying, paging, and location update. This article investigates the existing literature survey about user privacy for 5G networks, which continues the identity and location privacy. Also, it discusses most of the studies that handle user identifications in authentication, paging, and location update. This article discusses the various privacy issues in the 5G network that use IMSI in clear text or temporary identities such as TMSI & C‐RNTI with IMSI to disclose user identity privacy. This article also investigates the existing literature on user identity and location privacy and highlights the key parameters, issues, challenges, and future recommendations with potential solutions.
Low‐complexity GNSS carrier leakage detection and estimation via abnormal direct current energy identification
Authors: Bai Lu , Sun Chao , Zhao Hongbo , Feng Wenquan 
Published: March 2022

AbstractCarrier leakage due to faults within the satellite payload results in a waste of transmit power and affects the receiver functions. The existing methods are generally performed in the transform domain with high computation load and are unable to estimate the carrier leakage power. This letter presents a low‐complexity algorithm by monitoring the abnormal direct current component of baseband signal. The quantitative relationship between carrier leakage power and test statistics is derived here, and the capability of carrier leakage power estimation is provided. Analytical and simulation results show that it achieves a detection rate of more than 99% for carrier‐to‐noise ratio larger than 42 dB‐Hz and coherent integration time larger than 10 ms. It also greatly saves millions of multiplications compared with the conventional frequency‐domain method.