bluuebunny/crossref_metadata_2025_split huggingface dataset:
Theoretical Model and Computer Simulation of Power Utility Matrix for the Integrated Distributed Energy Resources
Authors: Jin A.J. , SU J. , Liu D. 
Published: July 2022

Abstract
In this article, the authors methodically study the optimized distributed energy resources (DER)/ systems in terms of energy generation, consumption, transaction, and scheduling. They discovered a mathematical model that allows the users/ prosumers to arrive at the optimal trade-off among the three critical output functions including the output power, the energy benefit/cost, and its carbon footprint in operation. Systematic characterization in the given scenarios was discussed. Math model is classified into three or more eigenstates of the power utility matrix (PUM) model which is, in the linear algebra, also called the eigenstates approach [in Eigen space]. Mathematical model is a major discovery that has PUM and renders a transformation framework. This article investigates a type of so-called 3i3o model transforming three input variables/ parameters [or 3i parameters in the present case] into three output functions [or 3o functions]. Eigenstates approach of PUM may conveniently decouple the three critical outputs from one another; i.e., within a specified range, the user can increase the power output without affecting the amount of carbon by-product (output for DER, and with renewable energies). Furthermore, computer modeling is employed to resolve the optimal scheduling of energy within/ among the energy sources. Energy blockchain (EBC) approach further studies the values of several design rules. Theoretical model leads to a value dependency law that helps the users/ prosumers to benefit financially from DER. Finally, a carbon emission law of PUM is discovered within the DER design and is investigated in detail.
GBP2 acts as a member of the interferon signaling pathway in lupus nephritis
Authors: Zhang Yuan , Liao Yinping , Hang Qing , Sun Dong , Liu Ya 
Published: July 2022

Abstract
Lupus nephritis (LN) is a common and serious clinical manifestation of systemic lupus erythematosus (SLE). However, the pathogenesis of LN is not fully understood. The currently available treatments do not cure the disease and appear to have a variety of side effects in the long term. The purpose of this study was to search for key molecules involved in the immune response during the development of LN through bioinformatics techniques to provide a reference for LN-specific targeted therapy. The GSE112943 dataset was downloaded from the Gene Expression Omnibus (GEO) database, and 20 of the samples were selected for analysis. In, total 2330 differentially expressed genes were screened. These differentially expressed genes were intersected with a list of immune genes obtained from the IMMPORT immune database to obtain a total of 128 differentially expressed immune-related genes. Enrichment analysis showed that most of these genes were enriched in the interferon (IFN) signaling pathway. Gene set enrichment analysis (GSEA) revealed that the overall expression information of the sample was also significantly enriched in the interferon signaling pathway. Further analysis of the core gene cluster showed that nine genes, GBP2, VCAM1, ADAR, IFITM1, BST2, MX2, IRF5, OAS1 and TRIM22, were involved in the interferon signaling pathway. According to our analysis, the guanylate binding protein 2 (GBP2), interferon regulatory factor 5 (IRF5) and 2'-5'-oligoadenylate synthetase 1 (OAS1) genes are involved in three interferon signaling pathways. At present, we do not know whether GBP2 is associated with LN. Therefore, this study focuses on the relationship between GBP2 and LN pathogenesis. We speculate that GBP2 may play a role in the pathogenesis of LN as a member of the interferon signaling pathway. Further immunohistochemical results showed that the expression of GBP2 was increased in the renal tissues of LN patients compared with the control group, confirming this conjecture. In conclusion, according to our study, GBP2 is a member of the interferon signaling pathway that may have implications for the pathogenesis of LN and serves as a potential biomarker for LN.
Fumonisin B1 aggravates inflammatory injury via mTORC1/pyroptosis, while promotes viral replication via mTORC1/apoptosis in Canine influenza virus-infected mice and A549 cells
Authors: He Wenmiao , Liu Dandan , Zhang Ping , Qu Jie , Yuan Xin , Li Xin , Chen Xingxiang , Huang Kehe 
Published: July 2022

Abstract
Canine influenza virus (CIV) has spread across the world and been a risk to canine and human. Fumonisin B1 (FB1) is a mycotoxin in feed and food, its pollution is low-level but very common. The co-occurrence of FB1 exposure and CIV infection is unavoidable. Here, we investigated the effects of low-dose FB1 exposure on CIV-induced inflammatory injury, viral replication and the underlying mechanisms in vivo and in vitro. In CIV-infected mice, low-dose FB1 (0.25, 0.5 and 0.75 mg/kg p.i.) treatment promoted systemic and lung inflammatory injury, as demonstrated by increased expressions of pro-inflammatory cytokines in serum and lung, increased occurrence of hemophagocytosis in spleen, promoted macrophage aggregation in lung, aggravated barrier damage and pathological injury of lung. In CIV-infected pulmonary epithelial model A549 cells, low-dose FB1 treatment significantly promoted the increase in pro-inflammatory cytokines expressions and the decrease in tight junction proteins expressions. Meanwhile, FB1 treatment promoted viral replication in mice and A549. Importantly, FB1 promoted CIV-inhibited mTOR/P70S6K signaling pathway and CIV-induced NLRP3-dependent pyroptosis, and inhibited CIV-induced apoptosis. Furthermore, mTORC1 inhibitor rapamycin blocked FB1-promoted pyroptosis, promoted FB1-inhibited apoptosis, and reversed FB1-promoted inflammatory injury and viral replication. NLRP3 inhibitor MCC950 attenuated FB1-aggravated inflammatory injury rather than viral replication, and apoptosis activator LY294002 reversed FB1-promoted viral replication rather than inflammatory injury. Summarily, low-dose FB1 exposure aggravated CIV-induced inflammatory injury and viral replication in vivo and in vitro via mTORC1-triggered apoptosis-pyroptosis shift. Our study provided new sights into the influence of mycotoxin on the virus-host interaction and the CIV control.
Analysis of drug resistance and virulence of new sequence type methicillin-resistant Staphylococcus aureus ST6905
Authors: Wan Jiahong , Ou Yangxue , Liu Xin , Yu Ting , Guo Shihui , Ren Jingjing , Zuo Qianfei , Wang Ning 
Published: July 2022

Abstract
Object: To reveal the drug resistance and virulence of new ST HA-MRSA ST6905 in Chongqing, we explore its drug resistance genotype and virulence characteristics, and provide basis for clinical treatment of patients. Methods: We applied the disc diffusion method to conduct antimicrobial susceptibility tests on a clinical isolated HA-MRSA. Multilocus sequence typing (MLST), whole genome sequencing, growth curve analysis, mouse survival rate analysis and invasiveness test were perfomed to the isolate. Results: The results of disc diffusion showed that the isolate was resistant to fourteen kinds of antibacterial drugs to varying degrees. Thirteen kinds of antibacterial drugs were completely resistant. MLST analysis suggested that the isolate belonged to the newly described sequence type (ST) 6905. Whole genome sequencing analysis results showed that HA-MRSA ST6905 carries twenty-six types of drug resistance genes and twelve types of virulence genes related to adhesion, host immune escape, secretion, extracellular enzyme encoding, iron uptake and other functions. The gene island prediction results showed that there are sixteen gene islands in HA-MRSA ST6905 which carry multiple drug resistance genes and virulence. Predictive analysis of HA-MRSA ST6905 prophage and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) showed that 4 prophage and 29 CRISPR were found. Collectively, the results of growth curve test, survival analysis and invasiveness test showed that HA-MRSA ST6905 had strong growth ability and virulence. Conclusions: The new sequence type HA-MRSA ST6905 in Chongqing has a high level of virulence and drug resistance, which may have a stronger ability to acquire foreign genes. In addition, the results of this study also revealed genetic diversity of MRSA in Chongqing, among which the number of new sequence types is constantly increasing.
Characterization of CAPA Peptide and Its Receptor in Bemisia tabaci
Authors: Thakur Sudeshna , Jindal Vikas 
Published: July 2022

Abstract
The diuresis process in insects is under the regulation of CAPA neuropeptides, which activate the specific cognate receptor i.e CAPAr. In this study, we characterized the CAPAr gene (BtabCAPAr) in whitefly, Bemisia tabaci Asia II 1 for the first time. The two splicing isoforms of the BtabCAPAr gene i.e BtabCAPAr-1 and BtabCAPAr-2 which included six (421 aa) and five (355 aa) exons, respectively were recorded. The third exon was missing in the BtabCAPAr-2 isoform as compared to the BtabCAPAr-1 isoform. The transmembrane topology depicted the presence of seven and five transmembrane regions in BtabCAPAr-1 and BtabCAPAr-2, respectively. The relative BtabCAPAr gene expression in different whitefly life stages revealed the highest (3.76 folds) expression level of the BtabCAPAr gene in the adult stage as compared to the egg stage. The expression of the BtabCAPAr gene in the nymphal and pupal stage was found to be on a par with each other as well as egg stage. Two CAPA peptides, CAPA-PVK1 and CAPA-PVK2 were identified through a functional luminescence assay, which strongly activated the BtabCAPAr-1 receptor with very low EC50 values of 0.067 nM and 0.053 nM, respectively. The basic information generated in the study will help develop biostable peptides, which can be tested further and may lead to the development of new generation insecticides.
Effect of stocking density and feeding regimes on haematology, stress and histological recovery in stunted Lebeo rohita fingerlings reared in cage culture
Authors: Paswan Vinod Kumar , Rawat Kiran Dube , Srivast Prem Prakash , Prakash Chandra , Aklakur M. D. , R Somu Sunder Lingam , Sangavi Sivan , Kumar Munish , Poojari Nalini 
Published: July 2022

Abstract
A 330-day field trial was conducted to evaluate the effect of stocking density and feeding ration on stunted Labeo rohita (Hamilton, 1822) fingerling reared in floating net cages. The stunted fingerling of L. rohita with an average body weight 38.23 ± 1.90 g were stocked in cages (3 × 3 × 3 m) at different densities viz. T1 (10), T2 (15), T3 (20) and T4 (25) fish/m3 and fed with varying levels of feeding rations at 3, 4, 5 and 6% at each stocking density. The 4×4 factorial design was used, and each density and feeding level kept in triplicate, and fed with commercial pellet feed (crude protein 28% and fat 5%) twice in a day. The significant recovery was observed in the T1 (10*5 and 10*6) treatment groups, which showed highest Hb, RBC, PCV and lowest WBC content at the end of experiment. Similarly, significant changes were observed in glucose, cortisol and lactate dehydrogenase (LDH), which were highest in higher stocking density (T4), and normalized in lower stocking T1 (10*5 and 10*6) treatment groups. Histological examination showed, almost complete recovery of structural changes such as swelling/ edema primary lamellae, hyperplasia of basal epithelium between the secondary lamellae of gill and necrosis in liver of lower stocking densities (10 and 15 fish/m3). In contrast, greater structural changes in both the organs were observed in the higher stocking density groups (20 and fish nos/m3). Based on the results, it can be concluded that maximum growth and complete recovery (in term of haematology, stress and histological changes) were observed in lower stocking density (10 fish/m3) fed with 5 to 6% feeding levels. Hence, in an Indian reservoir cage-based cultures, 10 fish/m3 fed with 5 to 6% feeding rations can be recommended at commercial scale to get maximum and sustainable profit by using the stunted L. rohita fingerling.
Twenty-four-month interim results from a prospective clinical trial evaluating the performance and safety of a cellular bone allograft in patients undergoing lumbar spinal fusion
Authors: Park Daniel , Wind Joshua , Lansford Todd 
Published: July 2022

Abstract
Autologous bone grafts are the gold standard for spinal fusion, however harvesting autologous bone can result in donor site infection, haematomas, increased operative time, and prolonged pain. Cellular bone allografts (CBAs) are an alternative that avoids the need for bone harvesting, and may increase fusion success. The present study examined the efficacy and safety of CBA when used as an adjunct to lumbar arthrodesis. A prospective multicenter clinical trial was conducted in adult patients undergoing lumbar spinal fusion with CBA. Radiographic fusion status was assessed by an independent review of dynamic radiographs and CT scans. Clinical outcomes were assessed with the Oswestry Disability Index (ODI), and visual analog scales (VAS) for back and leg pain. Adverse events were assessed through the 24-month follow-up. The presented data represents an analysis of available patients (N = 86) at 24-months follow-up. Successful fusion was achieved in 95.3% of patients. Clinical outcomes showed statistically significant improvements from baseline in ODI, VAS-Back, and VAS-Leg outcome measures. No patient characteristics or surgical factors were associated with pseudoarthrosis. The use of CBA resulted in a high rate of successful lumbar arthrodesis. Clinical outcomes demonstrated significant improvements in pain and disability.
Four-dimensional computed tomographic images evaluation of change of condylar movement with and without implant-supported removable prostheses in the fibular mandible: a pilot case series report
Authors: Yamashita Junya , Hashikawa Kazunobu , Kakei Yasumasa , Takeda Daisuke , Negi Noriyuki , Sekitani Toshinori , Sakakibara Akiko , Kimoto Akira , Hasegawa Takumi , Akashi Masaya 
Published: July 2022

Abstract
Purpose: Although it is believed that implant-supported removable prostheses (ISrP) improve the quality of life of patients who undergo mandibular reconstruction, few studies have focused on the effect of ISrP in the fibular mandible on the function of the temporomandibular joint. This pilot case series aimed to determine whether four-dimensional computed tomography (4DCT) images allow for the evaluation of changes in condylar movements with and without ISrP.Methods: Three patients who underwent ISrP following segmental mandibulectomy and free-flap reconstruction were evaluated. The participants were instructed to masticate a cookie during the 4DCT scan. The distance between the most anterior and posterior positions of the condyles on the sagittal view of the 4DCT images during chewing of the cookies was measured and compared with and without ISrP. Ethical approval was granted by the Medical Ethics Committee of Kobe University on 25 May, 2020 (No. B200052).Results: Although 4DCT revealed changes in the distances of condylar protrusion with and without wearing ISrP, there were no obvious differences among the three patients.Conclusion: The 4DCT motion analysis allows for the evaluation of the effect of wearing ISrP on condylar movements during mastication in patients with mandibular reconstruction and may become a useful objective evaluation method for the functional evaluation of ISrP.
Safety and efficacy of fecal microbiota transplantation in the treatment of graft-versus-host disease: a systematic review and meta-analysis
Authors: Bilinski Jaroslaw , Qiao Xiaoying , Wang Leyi , Yang Tianyu , Luo Rongmu , Yang Guibin 
Published: July 2022

Abstract
This article evaluates the efficacy and safety of FMT in the treatment of GVHD after HSCT using a systematic literature search to conduct a meta-analysis constructed of studies involving GVHD patients treated with FMT. 23 studies were included, among which 2 prospective cohort studies, 10 prospective single arm studies, 2 retrospective single arm studies, 2 case series and 7 case reports, comprise a total of 242 patients with steroid-resistant or steroid-dependent GVHD secondary to HSCT who were treated with FMT. 100 cases achieved complete responses, while 61 cases showed partial responses, and 81 cases presented no effect after FMT treatment. The estimate of clinical remission odds ratio was 5.51 (95% CI 1.49-20.35) in cohort studies, and the pooled clinical remission rate is 64% (51%-77%) in prospective single arm studies and 81% (62%-95%) in retrospective studies, case series and case reports. Five (2.1%) patients had FMT-related infection events, but all recovered after treatment. Other adverse effects were mild and acceptable. Microbiota diversity and composition, donor type, and other related issues were also analyzed. The data proves that FMT is a promising treatment modality of GVHD, but further validation of its safety and efficacy is still needed with prospective control studies.
Extreme-ultraviolet wave and accompanying loop oscillations
Authors: Devi Pooja , Chandra Ramesh , Awasthi Arun Kumar , Schmieder Brigitte , Joshi Reetika 
Published: July 2022

Abstract
In this article, we present the observations of an Extreme-Ultraviolet (EUV) wave, which originated from the active region (AR) NOAA 12887 on 28 October 2021 and its impact on neighbouring loops. The event was observed by the Atmospheric Imaging Assembly (AIA) onboard the Solar Dynamics Observatory (SDO) satellite at various wavebands and by the Solar TErrestrial RElationsObservatory-Ahead (STEREO–A), EUVI and COR1 instruments with a different view angle than SDO. We show that the EUV wave consists of severalwaves as well as non-wave phenomena. The wave–nature component includes:fast–mode part of the EUV wave, creation of oscillations in nearby loops andthe appearance of wave trains. The non-wave component consists of stationary fronts. We perform the analysis of selected oscillating loops and find the periods of these oscillation ranges from 230 – 549 s. Further, we compute the density ratio inside and outside the loops and the magnetic field strength. The computed density ratio and magnetic field are found in the range of 1.08 – 2.92 and 5.75 –8.79 G, respectively. Finally using the 3D point of view of the satellites we found that the EUV wave propagates ahead of the CME leading edge.
High-density Integrated Photonic Tensor Processing Unit with a Matrix Multiply Compiler
Authors: Ma Xiaoxuan , Peserico Nicola , Khaled Ahmed , Guo Zhimo , Nouri Behrouz , Dalir Hamed , Shastri Bhavin , Sorger Volker 
Published: July 2022

Abstract
Machine learning and artificial intelligence (AI) is becoming a ubiquitous technology of the looming industry-4.0 era. However, progress of adopting intelligent automation of systems is limited by hardware overhead such as throughput, power consumption, and latency. At a conceptual level, electronics is at the end of its scaling law and alternative accelerators are sought after. Optical co-processors offer a high-degree of algorithmic homomorphism to implement general matrix-matrix multiplication operations via on-the-fly multiplication performed by electro-optic components, and accumulation operations performed by photodetectors. However, recent emerging photonic AI engines are cumbersome to program, follow overhead-heavy scaling laws, or rely on discretely-packaged photonic components, all reducing performance. Here we introduce a photonic tensor core processor featuring a complete chip-integrated multiply-accumulate engine on the photonic circuits, signal parallelism via wavelength division multiplexing, and tunable 5-bit electronic programmable weights, all integrated into a small-formfactor silicon photonics platform. This approach shows a high throughput-efficiency AI engine (0.21 TOPS/W). Using this stand-alone hybrid photonic-electronic machine learning accelerator, we demonstrate versatile applications including low-error image filtering and edge detection, augmented reality, and high-accuracy machine learning image classification tasks. This hybrid electronic-photonic tensor processor offers a versatile low-overhead and compact formfactor solution for extreme edge AI applications, but also can be utilized for in-cloud machine learning training tasks.
Computing Education Research in Social Media, News, Blogs, Patents And Blogs: Capturing The Impact And The Chatter with Altmetrics
Authors: Saqr Mohammed , López-Pernas Sonsoles , Apiola Mikko 
Published: July 2022

Abstract
Research impact goes beyond academia and exists in the multiplicity of digital platforms that we use to read, share, and discuss knowledge. Computing education research (CER) is no exception: it is created in academia and typical research institutions but is talked about widely on social media, blogs, and news websites. The aim of this study is to have a comprehensive analysis of how research in CER has been received, talked about in social media, discussed on blogs, and spread to the news and media. In addition to common analysis of trends of growth, we analyze trends of usage of social media and quantitative analysis of platforms, articles, and venues. The analysis also includes which articles in which subfields had a wide impact, and for whom (i.e, which platforms had more impact). The results show that Altmetrics adoption is weak, yet increasingly growing fast. Gender and diversity issues made it to popular news sites e.g., Scientific American, Los Angeles Times and Christian Science Monitor. While articles about ethics, programming education, introductory courses as well as computational thinking and inclusion have captured the attention of social media users. There was weak –or no correlation between article, author or topic impact and the traditional impact measures e.g., citation count.
Agro-food greenhouse gas emissions are increasingly driven by foreign demand
Authors: Pinero Pablo , Aguilera Eduardo , Travieso Emiliano , Infante-Amate Juan , Bruckner Martin , Gerber James , Lassaletta Luis , Mueller Nathaniel , Sanz-Cobena Alberto 
Published: July 2022

Abstract
Greenhouse gas emissions embodied in international trade have risen sharply over the last few decades because of the globalization of economies and countries’ productive specialization. We have built a model able to trace all agro-food emissions along global value chains for 1986–2013. The results show that while the domestic fraction of food emissions has slightly decreased, the foreign fraction has grown by 75%, accounting for 24% of all agro-food emissions today. A few supply chains concentrate most of this increase, with consumption of animal products explaining 70% of all embodied emissions in trade. It was also found that higher incomes resulted in higher percentages of foreign agro-food emissions, and that increasing the proportion of imports in these footprints can be associated with lower per capita emissions. Because trade increasingly redistributes agro-food emissions around the world, national mitigation efforts should be complemented with strong international and coordinated cooperation actions.