bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the structural characteristics of the Adult Social Care Outcomes Toolkit (ASCOT) and ASCOT-Carer
Authors: Rand Stacey , Towers Ann-Marie , Malley Juliette , Silarova Barbora 
Published: February 2022

Background: Measurement models inform the approach to assess a measure’s validity and also how a measure is understood, applied and interpreted. With preference-based measures, it is generally accepted that they are formative; however, if they are applied without preferences, they may be reflective, formative or mixed. In this study, we sought to empirically test whether the reflective, formative or mixed measurement model best describes PBMs of social care-related quality of life (ASCOT, ASCOT-Carer). We also explored the network approach, as an alternative. Methods: ASCOT and ASCOT-Carer data were analyzed using confirmatory factor analysis and Multiple Indicators Multiple Causes models to test reflective, formative or mixed measurement models, respectively. Network analysis of partial correlations using the Gaussian graphical model was also conducted. Results: The results indicated that the reflective measurement model is the worst fit for ASCOT and ASCOT-Carer. The formative or mixed models may apply to ASCOT. The mixed model was the best fit for ASCOT-Carer. The network analysis indicated that the most important or influential items were Occupation and Personal cleanliness and comfort (ASCOT) and Time and space and Self-care (ASCOT-Carer). Conclusions: The ASCOT and ASCOT-Carer are best described as formative/mixed or mixed models, respectively. These findings may guide the approach to the validation of cross-culturally adapted and translated versions. Specifically, we recommend that EFA be applied to establish structural characteristics, especially if the measure will be applied as a PBM and as a measure of SCRQoL. Network analysis may also provide further useful insights into structural characteristics.
Recuperación y procesamiento de carbones de techos y pisos mezclados con estéril de la empresa Cerrejón Ltda.
Authors: Mercado Polo Luis Alberto 
Published: February 2022

Los problemas que pueden existir gracias al manejo que se da en el Cerrejón han dado como resultado el deterioro de la fauna y flora de las regiones afectada; no obstante, gracias a la Política de Seguridad, Salud, Medio Ambiente y Comunidades que ofrece la compañía, se puede afirmar que dicha empresa se interesa por escuchar propuestas las cuales disminuyan el impacto ambiental que conlleva dicha actividad minera. Entre las problemáticas encontradas una de las mayores son los incendios forestales provocados por la autocombustión del carbón el cual al estar mezclados con el material estéril en algún momento tiende a subir temperaturas, ya que este carbón ha si extraído de su entorno y ha entrado en contacto con el oxígeno y con agentes externos que provocan la combustión. Hay que prestar atención al posible riesgo de su combustión espontánea debido a la presencia de carbón en los estériles y en la reacción exotérmica de oxidación de las piritas. Dados los contenidos habituales de carbón (< 5 %), si los rellenos están adecuadamente compactados, y el contenido de aire es muy bajo, puede excluirse de combustión espontánea. Un ejemplo de combustión espontánea se produjo en el terraplén entre los pp.kk. 414/850 al 415/130 de la Línea Madrid-Barcelona por Caspe. En 2006, se hizo un estudio geológico-geotécnico del terraplén que presentaba un proceso de inestabilidad debido a la combustión continua del material constituyente del núcleo, afectando a un tramo de 45 m de vía con un espesor de relleno de hasta 8 m. Al tratarse de un relleno localizado la medida correctora adoptada fue la sustitución y construcción de un nuevo terraplén.
Genetic testing in prostate cancer management: Considerations informing primary care
Authors: Giri Veda N. , Morgan Todd M. , Morris David S. , Berchuck Jacob E. , Hyatt Colette , Taplin Mary‐Ellen 
Published: February 2022

AbstractInherited genetic mutations can significantly increase the risk for prostate cancer (PC), may be associated with aggressive disease and poorer outcomes, and can have hereditary cancer implications for men and their families. Germline genetic testing (hereditary cancer genetic testing) is now strongly recommended for patients with advanced/metastatic PC, particularly given the impact on targeted therapy selection or clinical trial options, with expanded National Comprehensive Cancer Network guidelines and endorsement from multiple professional societies. Furthermore, National Comprehensive Cancer Network guidelines recommend genetic testing for men with PC across the stage and risk spectrum and for unaffected men at high risk for PC based on family history to identify hereditary cancer risk. Primary care is a critical field in which providers evaluate men at an elevated risk for PC, men living with PC, and PC survivors for whom germline testing may be indicated. Therefore, there is a critical need to engage and educate primary care providers regarding the role of genetic testing and the impact of results on PC screening, treatment, and cascade testing for family members of affected men. This review highlights key aspects of genetic testing in PC, the role of clinicians, with a focus on primary care, the importance of obtaining a comprehensive family history, current germline testing guidelines, and the impact on precision PC care. With emerging evidence and guidelines, clinical pathways are needed to facilitate integrated genetic education, testing, and counseling services in appropriately selected patients. There is also a need for providers to understand the field of genetic counseling and how best to collaborate to enhance multidisciplinary patient care.
Mutual Recognition Procedure for the Registration of Medicines: New Challenges or Opportunities
Authors: Foteeva A. V. , Barshadskaya O. S. , Rostova N. B. 
Published: February 2022

Introduction. An important task for pharmaceutical manufacturers is to bring high quality, effective and safe medicines to the market. In the event that the country's resources are not enough, drugs that have been successfully registered in other countries come to the rescue.Aim. To study the possibilities and advantages of the procedure of mutual recognition of registration medicinal products as a potential for the development of domestic producers.Materials and methods. The materials of the study were available publications in peer-reviewed journals on thematic queries based on keywords of the selected topic, official websites, regulatory legal acts, regulating the procedure for registering medicinal products in the EU and the Russian Federation.Results and discussion. New approaches to registration within the framework of the Eurasian Economic Union (using the example of the mutual recognition procedure) are considered from the perspective of new opportunities and emerging problems for domestic manufacturers of generic drugs. A comparative analysis of the mutual recognition procedure and the national procedure for registration of medicinal products revealed a number of advantages for domestic manufacturers, favoring the introduction of medicinal products into circulation on the territory of the EAEU.Conclusion. The review of the process of harmonization of the registration practice of medicinal products in the EAEU speaks of the prospects of using the mutual recognition procedure for developing the potential of domestic manufacturers and facilitating access to effective and safe drugs.
Properties and Prospects of Application of the Whey Protein Lactoferrin in Medicine and Veterinary Medicine (Review)
Authors: Zhilyakova E. T. , Novikov O. O. , Khmyrov A. V. , Fadeeva D. A. , Gulyaeva V. E. , Malyutina A. Yu. , Avtina N. V. 
Published: February 2022

Introduction. Lactoferrin is a biologically active substance, a natural glycoprotein from the group of iron-containing proteins, transferrin. This article is devoted to a review of the literature data on the properties and prospects for the use of lactoferrin in medicine and veterinary medicine.Text. The problem of widespread use of lactoferrin is the need to use a large volume of raw materials, the difficulty of extracting it from agricultural raw materials and subsequent purification. In this view, at present, it is very promising to use transgenic animals to obtain such a valuable compound in the required volume. Discovered in 1939 in cow's milk, lactoferrin exhibits a wide spectrum of biological activity, new properties of this protein are constantly being established. The most studied are the immunomodulatory effects, anti-inflammatory, antimicrobial, antiviral, antifungal activities of lactoferrin, and the search for the possibility of using this compound for the treatment and prevention of the new coronavirus infection SARS-CoV-2, as well as for the prevention of postCOVID complications, has begun. In recent years, the antitumor activity of lactoferrin has been actively studied, as well as the prospects for its use as a biomarker for early diagnosis of neurodegenerative diseases. Lactoferrin can play a special role in the delivery of drugs to target organs, as well as in the manufacture of functional food products and various drugs for both humans and animals.Conclusion. Thus, the performed theoretical study and the data obtained on a wide spectrum of biological activity of lactoferrin confirm the prospects and expediency of the development of formulations and technology of drugs, functional food products, veterinary drugs and animal products based on lactoferrin.
Scanning Electron Microscopy in the Analysis of Species of the Genus Persicaria Mill
Authors: Gudkova A. A. , Chistyakova A. S. , Sinetskaya D. A. , Slivkin A. I. , Bolgov A. S. , Bolgova M. A. 
Published: February 2022

Introduction.Scanning electron microscopy acts as a promising method of analysis, allowing to describe in detail the identification features of closely related plant species, as well as to conduct micro-roentgenstructural analysis of the sample in the selected area with high accuracy. The method is used to study the morphology of the surface and express determination of the composition of elements in various fields (physics, materials science, medicine, however, the use of the method of scanning/raster electron microscopy for the analysis of plant raw materials in pharmacy is limited.Aim.The purpose of the study was to study species of the genus Persicaria Mill. using scanning electron microscopy.Materials and methods.The objects of study were the Persicaria maculosa S.F. Gray, Persicaria hydropiper (L.) Delarbre, Persicaria tomentósa (Schrank) E.P. Bicknell, Persicaria mínor (Huds.) Opiz, Persicaria amphibia (L.) Delarbre, Persicaria amphibia var. terrestris (Leyss.) Munshi & Javeid, harvested during flowering in the Voronezh region. The study of samples by scanning electron microscopy was carried out on an electron microscope JSM-6510LV (Center for Collective Use of Voronezh State University).Results and discussion.With the help of scanning electron microscopy, morphological and anatomical signs of leaf plates of six species of the genus Persicaria were investigated and new diagnostic signs were identified. As a result of micro-X-RAY analysis, the content of some elements (potassium, calcium and magnesium) was established in the objects of study.Conclusion.For the first time to analyze the surface morphology of the leaf plate of species of the genus Persicaria Mill. the method of scanning electron microscopy is used. The features of the stomatal apparatus, trichomes and glands on the leaves of the studied species of Persicaria are clarified. With the help of micro-roentgenstructural analysis it was found, that a greater amount of magnesium is typical for the leaves of Persicaria mínor, calcium – for the leaves of Persicaria hydropiper, and potassium – for the leaves of Persicaria maculosa.
Estudio sobre el estigma percibido y el estigma experimentado según los usuarios de servicios de salud mental en la Ciudad de Buenos Aires: Su impacto en la recuperación
Authors: Geffner Norma Irene , Agrest Martín 
Published: February 2022

Testimonios en primera persona de personas con padecimiento mental permiten observar que el estigma es una dinámica social que conforma uno de los más importantes obstáculos para la recuperación personal. La defensa frente a las percepciones de estigma se relaciona de manera dinámica con el proceso de recuperación y parte de una redefinición de la enfermedad como algo inesencial de la persona. Realizamos un estudio cualitativo para conocer la percepción del estigma y sus implicancias en la recuperación de veintiún usuarios que recibían tratamiento ambulatorio de salud mental en una ONG de la Ciudad Autónoma de Buenos Aires. El análisis siguió una estrategia fenomenológica. Los usuarios mencionaron con frecuencia que la ignorancia y la falta de información propia y ajena sostienen el estigma. Asimismo, destacaron las consecuencias percibidas en la falta de abordaje de esta dinámica en los tratamientos. La familia, los amigos, el trabajo, el apoyo entre compañeros y los tratamientos que se centran en la persona y sus capacidades fueron destacados como valores fundamentales. La recuperación se percibe como un proceso relacional que incluye: cuestionar la “mirada social” (estigma) y salir del estancamiento, nuevos aprendizajes y el reconocimiento y apropiación de las transformaciones y cambios positivos a partir de los aprendizajes. El análisis de las dinámicas de estigmatización y recuperación en las palabras de los “expertos por experiencia” puede significar un avance importante para que la comprensión de estos procesos gane terreno en la formación y en las prácticas en salud mental en América Latina.
Adenosine Kinase Inhibition Prevents Severe Acute Pancreatitis via Suppressing Inflammation and Acinar Cell Necroptosis
Authors: Sun Shukun , Han Yu , Zhang Chuanxin , Liu Han , Wang Bailu , Cao Shengchuan , Yuan Qiuhuan , Wei Shujian , Chen Yuguo 
Published: February 2022

Background: Inflammatory disorder and acinar cell death contribute to the initiation and progression of severe acute pancreatitis (SAP). Adenosine kinase (ADK) has potential effects on both inflammation and cell death. However, the role of ADK in SAP remains to be explored.Methods: To establish an experimental SAP model, male C57BL/6 mice were intraperitoneally injected with cerulein (50 μg/kg, seven doses at hourly intervals) and LPS (10 mg/kg, at the last cerulein injection). For ADK inhibition, ABT702 (1.5 mg/kg) was intraperitoneally injected 1 h before cerulein treatment. The pancreas and serum were collected and analyzed to determine the severity of pancreatic injury and explore the potential pathophysiological mechanisms. Pancreatic acinar cells (AR42J) were used to explore the in vitro effects of ADK inhibition on cerulein–induced inflammation and necroptotic cell death.Results: ADK inhibition notably attenuated the severity of SAP, as indicated by the decreased serum amylase (7,416.76 ± 1,457.76 vs. 4,581.89 ± 1,175.04 U/L) and lipase (46.51 ± 11.50 vs. 32.94 ± 11.46 U/L) levels and fewer pancreatic histopathological alterations (histological scores: 6.433 ± 0.60 vs. 3.77 ± 0.70). MOMA-2 and CD11b staining confirmed that ADK inhibition prevented the infiltration of neutrophils and macrophages. The phosphorylation of nuclear factor-κB (NF-κB) was also reduced by ADK inhibition. ADK inhibition markedly limited the necrotic area of the pancreas and prevented the activation of the necroptotic signaling pathway. Endoplasmic reticulum (ER) stress was activated in the pancreas using the SAP model and cerulein–treated AR42J cells whereas ADK inhibition reversed the activation of ER stress both in vivo and in vitro. Moreover, the alleviating effects of ADK inhibition on ER stress, inflammation, and cell necroptosis were eliminated by the adenosine A2A receptor antagonist.Conclusion: ADK inhibition reduced inflammation and necroptotic acinar cell death in SAP via the adenosine A2A receptor/ER stress pathway, suggesting that ADK might be a potential therapeutic target for SAP.
Combined Analysis of Myocardial Deformation and Oxygenation Detects Inducible Ischemia Unmasked by Breathing Maneuvers in Chronic Coronary Syndrome
Authors: Spicher Barbara , Fischer Kady , Zimmerli Zoe A. , Yamaji Kyohei , Ueki Yasushi , Bertschinger Carina N. , Jung Bernd , Otsuka Tatsuhiko , Bigler Marius R. , Gräni Christoph , von Tengg-Kobligk Hendrik , Räber Lorenz , Eberle Balthasar , Guensch Dominik P. 
Published: February 2022

IntroductionIn patients with chronic coronary syndromes, hyperventilation followed by apnea has been shown to unmask myocardium susceptible to inducible deoxygenation. The aim of this study was to assess whether such a provoked response is co-localized with myocardial dysfunction.MethodsA group of twenty-six CAD patients with a defined stenosis (quantitative coronary angiography &gt; 50%) underwent a cardiovascular magnetic resonance (CMR) exam prior to revascularization. Healthy volunteers older than 50 years served as controls (n = 12). Participants hyperventilated for 60s followed by brief apnea. Oxygenation-sensitive images were analyzed for changes in myocardial oxygenation and strain.ResultsIn healthy subjects, hyperventilation resulted in global myocardial deoxygenation (-10.2 ± 8.2%, p &lt; 0.001) and augmented peak circumferential systolic strain (-3.3 ± 1.6%, p &lt; 0.001). At the end of apnea, myocardial signal intensity had increased (+9.1 ± 5.3%, p &lt; 0.001) and strain had normalized to baseline. CAD patients had a similar global oxygenation response to hyperventilation (−5.8 ± 9.6%, p = 0.085) but showed no change in peak strain from their resting state (-1.3 ± 1.6%), which was significantly attenuated in comparison the strain response observed in controls (p = 0.008). With apnea, the CAD patients showed an attenuated global oxygenation response to apnea compared to controls (+2.7 ± 6.2%, p &lt; 0.001). This was accompanied by a significant depression of peak strain (3.0 ± 1.7%, p &lt; 0.001), which also differed from the control response (p = 0.025). Regional analysis demonstrated that post-stenotic myocardium was most susceptible to de-oxygenation and systolic strain abnormalities during respiratory maneuvers. CMR measures at rest were unable to discriminate post-stenotic territory (p &gt; 0.05), yet this was significant for both myocardial oxygenation [area under the curve (AUC): 0.88, p &gt; 0.001] and peak strain (AUC: 0.73, p = 0.023) measured with apnea. A combined analysis of myocardial oxygenation and peak strain resulted in an incrementally higher AUC of 0.91, p &lt; 0.001 than strain alone.ConclusionIn myocardium of patients with chronic coronary syndromes and primarily intermediate coronary stenoses, cine oxygenation-sensitive CMR can identify an impaired vascular and functional response to a vasoactive breathing maneuver stimulus indicative of inducible ischemia.
Effect of a Novel Pocket Compression Device on Hematomas Following Cardiac Electronic Device Implantation in Patients Receiving Direct Oral Anticoagulants
Authors: Fei Ye-Ping , Wang Lei , Zhu Chun-Yan , Sun Jing-Chao , Hu Hui-Lin , Zhai Chang-Lin , He Chao-Jie 
Published: February 2022

BackgroundA pocket hematoma is a well-recognized complication that occurs after pacemaker or defibrillator implantation. It is associated with increased pocket infection and hospital stay. Patients suffering from atrial fibrillation and undergoing cardiovascular electronic implantable device (CIED) surgery are widely prescribed and treated with direct oral anticoagulants (DOACs). In this study, the use of a novel compression device was evaluated to examine its ability to decrease the incidence of pocket hematomas following device implantation with uninterrupted DOACs.MethodsA total of 204 participants who received DOACs and underwent CIED implantation were randomized into an experimental group (novel compression device) and a control group (elastic adhesive tape with a sandbag). The primary outcome was pocket hematoma, and the secondary outcomes were skin erosions and patient comfort score. Grade 3 hematoma was defined as a hematoma that required anticoagulation therapy interruption, re-operation, or prolonged hospital stay.ResultsThe baseline characteristics of both groups had no significant differences. The incidence of grades 1 and 2 hematomas was significantly lower in the compression device group than in the conventional pressure dressing group (7.8 vs. 23.5 and 2.0 vs. 5.9%, respectively; P &lt; 0.01). Grade 3 hematoma occurred in 2 of 102 patients in the experimental group and 7 of 102 patients in the control group (2.0 vs. 6.9%; P = 0.03). The incidence rates of skin erosion were significantly lower, and the patient comfort score was much higher in the compression device group than in the control group (P &lt; 0.01). Multivariable logistic regression analysis showed that the use of novel compression device was a significant protective factor for pocket hematoma (OR = 0.42; 95% CI, 0.29–0.69, P = 0.01).ConclusionsThe incidence of pocket hematomas and skin erosions significantly decreases when the proposed compression device is used for patients undergoing device implantation with uninterrupted DOACs. Thus, the length of hospital stay and re-operation rate can be reduced, and patient comfort can be improved.Clinical Trial Registrationhttp://www.chictr.org.cn, identifier: ChiCTR2100049430.
Predictors and Mortality for Worsening Left Ventricular Ejection Fraction in Patients With HFpEF
Authors: Chen Liling , Huang Zhidong , Zhao Xiaoli , Liang Jingjing , Lu Xiaozhao , He Yibo , Kang Yu , Xie Yun , Liu Jin , Liu Yong , Yang Jin , Yu Weixu , Deng Wanling , Pan Yuxiong , Lu Jin , Yang Yanfang , Xie Xujing , Qian Xiaoxian , Xu Qingbo , Chen Longtian , Chen Kaihong , Chen Shiqun 
Published: February 2022

BackgroundDefinitions of declined left ventricular ejection fraction (LVEF) vary across studies and research results concerning the association of mortality with declined LVEF are inconsistent. Thus, this study aimed to assess the impact of early worsening LVEF on mortality in patients with heart failure (HF) with preserved ejection fraction (HFpEF) and to establish independent predictors of early worsening LVEF.Methods and ResultsA total of 1,418 consecutive patients with HFpEF with LVEF remeasurement from the Cardiorenal Improvement registry were included in this study. Worsening LVEF was defined as an absolute decline ≥ 5% from baseline LVEF within 3 to 12 months after discharge. The Cox and logistic regression analyses were performed to assess prognostic effects and predictors for worsening LVEF, respectively. Among 1,418 patients with HFpEF, 457 (32.2%) patients exhibited worsening LVEF. During a median follow-up of 3.2 years (interquartile range: 2.3–4.0 years), 92 (6.5%) patients died. Patients with HFpEF with worsening LVEF had higher mortality relative to those with nonworsening LVEF [9.2 vs. 5.2%; adjusted hazard ratio (aHR): 2.18, 95% CI: 1.35–3.52]. In the multivariate binary logistic regression analysis, baseline left ventricular end-diastolic dimension (LVEDD), LVEF, high-density lipoprotein cholesterol (HDL-C), atrial fibrillation (AF), and diabetes mellitus (DM) emerged as predictive factors of worsening LVEF.ConclusionThis study demonstrated that about one out of three patients with HFpEF experiences worsening LVEF during follow-up, which is associated with 2.2-fold increased mortality. Increased LVEDD and LVEF, low HDL-C levels, AF, and DM were predictors of worsening LVEF. Further studies are needed to prospectively assess the efficacy of early active management on prognosis in patients with HF with worsening LVEF.RegistrationClinicalTrials.gov, identifier NCT04407936.