bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematics of type IIB moduli stabilisation with odd axions
Authors: Cicoli Michele , Schachner Andreas , Shukla Pramod 
Published: April 2022

Abstract
Moduli stabilisation in superstring compactifications on Calabi-Yau orientifolds remains a key challenge in the search for realistic string vacua. In particular, odd moduli arising from the reduction of 2-forms (B2, C2) in type IIB are largely unexplored despite their relevance for inflationary model building. This article provides novel insights into the general structure of 4D $$ \mathcal{N} $$
N
= 1 F-term scalar potentials at higher orders in the α′ and gs expansion for arbitrary Hodge numbers. We systematically examine superpotential contributions with distinct moduli dependences which are induced by fluxes or non-perturbative effects. Initially, we prove the existence of a no-scale structure for odd moduli in the presence of (α′)3 corrections to the Kähler potential. By studying a partially SL(2, ℤ)-completed form of the Kähler potential, we derive the exact no-scale breaking effects at the closed string 1-loop and non-perturbative D-instanton level. These observations allow us to present rigorous expressions for the F-term scalar potential applicable to arbitrary numbers of moduli in type IIB Calabi-Yau orientifold compactifications. Finally, we compute the Hessian for odd moduli and discuss potential phenomenological implications.
Protrudin regulates FAK activation, endothelial cell migration and angiogenesis
Authors: Arora Amita , Kivelä Annukka M. , Wang Ling , Minkeviciene Rimante , Taskinen Juuso H. , Zhang Birong , Koponen Annika , Sun Jing , Shirane Michiko , Zhou You , Hotulainen Pirta , Raiborg Camilla , Olkkonen Vesa M. 
Published: April 2022

AbstractDuring angiogenesis, endothelial cells form protrusive sprouts and migrate towards the angiogenic stimulus. In this study, we investigate the role of the endoplasmic reticulum (ER)-anchored protein, Protrudin, in endothelial cell protrusion, migration and angiogenesis. Our results demonstrate that Protrudin regulates angiogenic tube formation in primary endothelial cells, Human umbilical vein endothelial cells (HUVECs). Analysis of RNA sequencing data and its experimental validation revealed cell migration as a prominent cellular function affected in HUVECs subjected to Protrudin knockdown. Further, our results demonstrate that knockdown of Protrudin inhibits focal adhesion kinase (FAK) activation in HUVECs and human aortic endothelial cells (HAECs). This is associated with a loss of polarized phospho-FAK distribution upon Protrudin knockdown as compared to Protrudin expressing HUVECs. Reduction of Protrudin also results in a perinuclear accumulation of mTOR and a decrease in VEGF-mediated S6K activation. However, further experiments suggest that the observed inhibition of angiogenesis in Protrudin knockdown cells is not affected by mTOR disturbance. Therefore, our findings suggest that defects in FAK activation and its abnormal subcellular distribution upon Protrudin knockdown are associated with a detrimental effect on endothelial cell migration and angiogenesis. Furthermore, mice with global Protrudin deletion demonstrate reduced retinal vascular progression. To conclude, our results provide evidence for a novel key role of Protrudin in endothelial cell migration and angiogenesis.
Ein neues Verständnis von Risikokommunikation in Public-Health-Notlagen
Authors: Dickmann Petra , Strahwald Brigitte 
Published: April 2022

ZusammenfassungDie Risikokommunikation öffentlicher Institutionen soll die Bevölkerung im Falle bestehender Risiken bei der Entscheidungsfindung unterstützen. In gesundheitlichen Notlagen wie der Coronavirus(SARS-CoV-2)-Pandemie spielt sie eine besonders wichtige Rolle. Bereits nach dem SARS-Ausbruch im Jahr 2003 hat die Weltgesundheitsorganisation (WHO) ihre Internationalen Gesundheitsvorschriften (IHR 2005) überarbeitet und gefordert, Risikokommunikation in allen Mitgliedsländern als einen Kernbereich in der Gesundheitspolitik zu etablieren. Während der gesundheitspolitische Akzent begrüßt wurde, konnten die Möglichkeiten der Risikokommunikation in diesem Bereich bisher nicht voll ausgeschöpft werden. Gründe sind u. a. Unstimmigkeiten im Begriffsverständnis der Risikokommunikation und die Vielzahl zur Verfügung stehender Methoden.Der vorliegende Diskussionsartikel soll dazu beitragen, ein neues Verständnis von Risikokommunikation in Public-Health-Notlagen (Emergency Risk Communication – ERC) zu etablieren. Es wird vorgeschlagen, neben den Risiken die Chancen der Krise stärker einzubeziehen und Risikokommunikation noch mehr als einen kontinuierlichen Prozess zu begreifen, der an verschiedenen Stellen optimierbar ist. Der Earlier-Faster-Smoother-Smarter-Ansatz und hierbei insbesondere die frühere Erkennung von Gesundheitsgefahren (Earlier) könnten das Management von Public-Health-Notlagen zukünftig unterstützen.
Sparse reduced-rank regression for simultaneous rank and variable selection via manifold optimization
Authors: Yoshikawa Kohei , Kawano Shuichi 
Published: April 2022

AbstractWe consider the problem of constructing a reduced-rank regression model whose coefficient parameter is represented as a singular value decomposition with sparse singular vectors. The traditional estimation procedure for the coefficient parameter often fails when the true rank of the parameter is high. To overcome this issue, we develop an estimation algorithm with rank and variable selection via sparse regularization and manifold optimization, which enables us to obtain an accurate estimation of the coefficient parameter even if the true rank of the coefficient parameter is high. Using sparse regularization, we can also select an optimal value of the rank. We conduct Monte Carlo experiments and a real data analysis to illustrate the effectiveness of our proposed method.
Strategies for data analytics projects in business performance forecasting: a field study
Authors: Schnegg Maël , Möller Klaus 
Published: April 2022

AbstractData analytics is applied in various fields, including business performance forecasting, but companies struggle with its implementation. Following a cross-sectional field study approach, we make two contributions. First, we elaborate on the central role played by the head controller in generating trust in analytics solutions and thus, making the project successful. Second, we identify three patterns in the way companies plan, implement, and then use data analytics in the context of business performance forecasting. The two successful patterns are the ones that start with a limited but tangible objective (either in term of information precision, or rapidity of processing) that can be expended in a second time.
A novel spatial filter to reduce north–south striping noise in GRACE spherical harmonic coefficients
Authors: Yi Shuang , Sneeuw Nico 
Published: April 2022

AbstractPrevalent north–south striping (NSS) noise in the spherical harmonic coefficient products of the satellite missions gravity recovery and climate experiment greatly impedes the interpretation of signals. The overwhelming NSS noise always leads to excessive smoothing of the data, allowing a large room for improvement in the spatial resolution if this particular NSS noise can be mitigated beforehand. Here, we put forward a new spatial filter that can effectively remove NSS noise while remaining orthogonal to physical signals. This new approach overcomes the limitations of the previous method proposed by Swenson and Wahr (2006), where signal distortion was large and high-order coefficients were uncorrectable. The filter is based on autocorrelation in the longitude direction and cross-correlation in the latitude direction. The NSS-type noise identified by our method is mainly located in coefficients of spherical harmonic order larger than about 20 and degree beyond 30, spatially between latitudes ± 60°. After removing the dominating NSS noise with our method, a weaker filter than before is added to handle the residual noise. Thereby, the spatial resolution can be increased and the amplitude damping can be reduced. Our method can coincidentally reduce outliers in time series without significant trend bias, which underpins its effectiveness and reliability.
Acorn flour and sourdough: an innovative combination to improve gluten free bread characteristics
Authors: Beltrão Martins Rita , Garzón Raquel , Peres José Alcides , Barros Ana I. R. N. A. , Raymundo Anabela , Rosell Cristina M. 
Published: April 2022

AbstractNowadays, challenges in gluten free breads (GFB) are focused on improving the nutritional and health benefits. Acorn flour is an underexploited sustainable ingredient, naturally gluten free, with many nutritional and technological advantages. The aim of this study was to explore the interaction of acorn flour supplementation (up to 35%) to rice flour and sourdough process to obtain rice based GFB. Different levels of rice flour replacement with acorn flour (0%, 23% and 35%), and sourdough (20%) were tested in a basic GFB recipe, and technological, nutritional, and functional GFB characteristics evaluated. The combination of acorn flour and sourdough was responsible for acidifying dough and bread. Breads containing 35:65 acorn flour: rice flour led to harder breads with lower crumb luminosity and with reddish and brownish tones, besides improved structural features when adding sourdough. That combination of sourdough and acorn flour reduced the rate and the extent of starch hydrolysis, as well as increase the minerals content, total phenolic compounds and antioxidant activity. Therefore, the combination of acorn flour and sourdough process allows obtaining rice based GFB with better nutritional pattern.
Benefits of diffusion-weighted imaging in pediatric acute osteoarticular infections
Authors: Habre Céline , Botti Paul , Laurent Méryle , Ceroni Dimitri , Toso Seema , Hanquinet Sylviane 
Published: April 2022

Abstract
Background
Contrast-enhanced magnetic resonance imaging (MRI) is recommended for the diagnosis of acute osteoarticular infections in children. Diffusion-weighted imaging (DWI) may be an alternative to the injection of gadolinium.

Objective
To evaluate unenhanced MRI with DWI in comparison to contrast-enhanced MRI for the diagnostic work-up of acute osteoarticular infections in children.

Materials and methods
This retrospective study included 36 children (age range: 7 months-12 years) with extra-spinal osteoarticular infections and MRI performed within 24 h of admission. MRI protocol included short tau inversion recovery (STIR), water-only T2 Dixon, T1, DWI, and gadolinium-enhanced T1 sequences. Two readers reviewed three sets of images: 1) unenhanced sequences, 2) unenhanced sequences with DWI and 3) unenhanced followed by contrast-enhanced sequences (reference standard). Sensitivity and specificity of sets 1 and 2 were compared to set 3 and assessed to identify osteoarticular infections: osteomyelitis (long bones, metaphyseal equivalents), septic arthritis and abscess (soft tissues, bone).

Results
All 14 cases of osteomyelitis in the metaphyses and diaphyses of long bones and all 27 cases of septic arthritis were identified by unenhanced sequences, but 4/16 abscesses were missed. For the diagnosis of abscess, DWI increased sensitivity to 100%. Among the 18 osteomyelitis in metaphyseal equivalents, 4 femoral head chondroepiphyses were identified by contrast-enhanced sequences only.

Conclusion
MRI for suspected pediatric acute osteoarticular infections is the best diagnostic modality to guide patient management. An unenhanced protocol with DWI may be an alternative to a contrast-based protocol, even in the presence of an abscess. However, gadolinium remains necessary to assess for chondroepiphyseal involvement of the femoral head.
CardiSort: a convolutional neural network for cross vendor automated sorting of cardiac MR images
Authors: Lim Ruth P. , Kachel Stefan , Villa Adriana D. M. , Kearney Leighton , Bettencourt Nuno , Young Alistair A. , Chiribiri Amedeo , Scannell Cian M. 
Published: April 2022

Abstract
Objectives
To develop an image-based automatic deep learning method to classify cardiac MR images by sequence type and imaging plane for improved clinical post-processing efficiency.

Methods
Multivendor cardiac MRI studies were retrospectively collected from 4 centres and 3 vendors. A two-head convolutional neural network (‘CardiSort’) was trained to classify 35 sequences by imaging sequence (n = 17) and plane (n = 10). Single vendor training (SVT) on single-centre images (n = 234 patients) and multivendor training (MVT) with multicentre images (n = 434 patients, 3 centres) were performed. Model accuracy and F1 scores on a hold-out test set were calculated, with ground truth labels by an expert radiologist. External validation of MVT (MVTexternal) was performed on data from 3 previously unseen magnet systems from 2 vendors (n = 80 patients).

Results
Model sequence/plane/overall accuracy and F1-scores were 85.2%/93.2%/81.8% and 0.82 for SVT and 96.1%/97.9%/94.3% and 0.94 MVT on the hold-out test set. MVTexternal yielded sequence/plane/combined accuracy and F1-scores of 92.7%/93.0%/86.6% and 0.86. There was high accuracy for common sequences and conventional cardiac planes. Poor accuracy was observed for underrepresented classes and sequences where there was greater variability in acquisition parameters across centres, such as perfusion imaging.

Conclusions
A deep learning network was developed on multivendor data to classify MRI studies into component sequences and planes, with external validation. With refinement, it has potential to improve workflow by enabling automated sequence selection, an important first step in completely automated post-processing pipelines.

Key Points
• Deep learning can be applied for consistent and efficient classification of cardiac MR image types.
• A multicentre, multivendor study using a deep learning algorithm (CardiSort) showed high classification accuracy on a hold-out test set with good generalisation to images from previously unseen magnet systems.
• CardiSort has potential to improve clinical workflows, as a vital first step in developing fully automated post-processing pipelines.
Platelet-rich plasma (PRP) in oncological patients: long-term oncological outcome analysis of the treatment of subcutaneous venous access device scars in 89 breast cancer patients
Authors: Eichler Christian , Üner Jens , Thangarajah Fabinshy , Radosa Julia , Zinser Max , Fischer Lotta Ada , Puppe Julian , Warm Matthias , Malter Wolfram , Lenz Caroline 
Published: April 2022

Abstract
Purpose
Platelet-rich plasma (PRP) is widely used product, and meta-analyses showed this product to be beneficial when applied to a wound area. This study group has already demonstrated increased patient satisfaction and lower complication rates in breast cancer patients who received PRP after removal of their subcutaneous venous access device. This work is a follow-up analysis focusing on oncologic safety. Currently, there is no long-term data on the use of PRP products in cancer patients available yet.

Methods
Between the years 2012–2016, venous access device removal was supported with the application of Arthrex ACP® (Autologous Conditioned Plasma)—a PRP product to improve the wound-healing process. All surgeries were performed in the breast cancer center of the municipal hospital of Cologne, Holweide, Germany. 35 patients received an application of Arthrex ACP® after port removal compared to the control group of 54 patients. Endpoints were local recurrence-free, distant recurrence-free as well as overall survival.

Results
Median follow-up was 45 months. No (0) adverse events were shown for cancer recurrence within the subcutaneous venous access device scar area. Thus, there seems to be no local oncogenic potential of the PRP product. All other endpoints as well as any-cause death numerically favor PRP use.

Conclusion
PRP products such as Arthrex ACP® seem to be oncological inert when applied after removal of subcutaneous access devices. This is the first study providing long-term data about overall survival, distant recurrence-free and local recurrence-free survival after applying PRP in high-risk cancer patients.
Immunohistochemical assessment of PD-L1 expression using three different monoclonal antibodies in triple negative breast cancer patients
Authors: Schmidt Gilda , Guhl Margit Maria , Solomayer Erich-Franz , Wagenpfeil Gudrun , Hammadeh Mohammed Eid , Juhasz-Boess Ingolf , Endrikat Jan , Kasoha Mariz , Bohle Rainer Maria 
Published: April 2022

Abstract
Background
PD-L1 receptor expression in breast cancer tissue can be assessed with different anti-human PD-L1 monoclonal antibodies. The performance of three specific monoclonal antibodies in a head-to-head comparison is unknown. In addition, a potential correlation of PD-L1 expression and clinico-pathological parameters has not been investigated.

Methods
This was a retrospective study on tissue samples of patients with histologically confirmed triple negative breast cancer (TNBC). PD-L1 receptors were immune histochemically stained with three anti-human PD-L1 monoclonal antibodies: 22C3 and 28-8 for staining of tumor cell membranes (TC) and cytoplasm (Cyt), SP142 for immune cell staining (IC). Three different tissue samples of each patient were evaluated separately by two observers in a blinded fashion. The percentage of PD-L1 positive tumor cells in relation to the total number of tumor cells was determined. For antibodies 22C3 and 28-8 PD-L1 staining of 0 to < 1% of tumor cells was rated "negative", 1–50% was rated "positive" and > 50% was rated "strong positive". Cyt staining was defined as “negative” when no signal was observed and as “positive”, when any positive signal was observed. For IC staining with SP142 all samples with PD-L1 expression ≥ 1% were rated as “positive”. Finally, the relationship between PD-L1 expression and clinico-pathological parameters was analyzed.

Results
Tissue samples from 59 of 60 enrolled patients could be analyzed. Mean age was 55 years. Both the monoclonal antibodies 22C3 and 28-8 had similar properties, and were positive for both TC in 13 patients (22%) and for Cyt staining in 24 patients (40.7%). IC staining with antibody SP142 was positive in 24 patients (40.7%), who were also positive for Cyt staining. The differences between TC and Cyt staining and TC and IC staining were significant (p = 0.001). Cases with positive TC staining showed higher Ki67 expression compared to those with negative staining, 40 vs 30%, respectively (p = 0.05). None of the other clinico-pathological parameters showed any correlation with PDL1 expression.

Conclusions
Antibodies 22C3 and 28-8 can be used interchangeably for PD-L1 determination in tumor cells of TNBC patients. Results for Cyt staining with 22C3 or 28-8 and IC staining with SP142 were identical. In our study PD-L1 expression correlates with Ki67 expression but not with OS or DFS.
Validation of a quantitative lateral flow immunoassay (LFIA)-based point-of-care (POC) rapid test for SARS-CoV-2 neutralizing antibodies
Authors: Pieri Massimo , Nicolai Eleonora , Nuccetelli Marzia , Sarubbi Serena , Tomassetti Flaminia , Pelagalli Martina , Minieri Marilena , Terrinoni Alessandro , Bernardini Sergio 
Published: April 2022

AbstractWith the widespread use of coronavirus disease 2019 (COVID-19) vaccines, a rapid and reliable method to detect SARS-CoV-2 neutralizing antibodies (NAbs) is extremely important for monitoring vaccine effectiveness and immunity in the population. The purpose of this study was to evaluate the performance of the RapiRead™ reader and the TestNOW™ COVID-19 NAb rapid point-of-care (POC) test for quantitative measurement of antibodies against the spike protein receptor-binding domain of severe respiratory syndrome coronavirus 2 (SARS-CoV-2) in different biological matrices compared to chemiluminescence immunoassay (CLIA) methods. Ninety-four samples were collected and analyzed using a RapiRead™ reader and TestNOW™ COVID-19 NAb kits for detecting neutralizing antibodies, and then using two CLIAs. The data were compared statistically using the Kruskal-Wallis test for more than two groups or the Mann-Whitney test for two groups. Specificity and sensitivity were evaluated using a receiver operating characteristic (ROC) curve. Good correlation was observed between the rapid lateral flow immunoassay (LFIA) test system and both CLIA methods. RapiRead™ reader/TestNOW™ COVID-19 NAb vs. Maglumi: correlation coefficient (r) = 0.728 for all patients; r = 0.841 for vaccinated patients. RapiRead™ reader/TestNOW™ COVID-19 NAb vs. Mindray: r = 0.6394 in all patients; r = 0.8724 in vaccinated patients. The time stability of the POC serological test was also assessed considering two times of reading, 12 and 14 minutes. The data revealed no significant differences. The use of a RapiRead™ reader and TestNOW™ COVID-19 NAb assay is a quantitative, rapid, and valid method for detecting SARS-CoV-2 neutralizing antibodies and could be a useful tool for screening studies of SARS-CoV-2 infection and assessing the efficacy of vaccines in a non-laboratory context.
The lived experience of gender dysphoria in autistic young people: a phenomenological study with young people and their parents
Authors: Cooper Kate , Butler Catherine , Russell Ailsa , Mandy William 
Published: April 2022

AbstractGender dysphoria is distress in relation to incongruence between an individual’s gender and sex assigned at birth. Gender clinics offer support for gender dysphoria, and there is a higher prevalence of autism in young people attending such clinics than in the general population. We aimed to investigate the lived experiences of autistic young people who have experienced gender dysphoria, and their parents, using a multi-perspectival IPA design. Young autistic people aged 13–17 years (n = 15), and their parents (n = 16), completed in-depth interviews about the young person’s experience of gender dysphoria. We analysed each individual transcript to generate individual themes, and for each of the dyads, developed themes which acknowledged the similarities and differences in parent–child perspectives. The first superordinate theme was coping with distress which had two subordinate themes; understanding difficult feelings and focus on alleviating distress with external support. This theme described how young people were overwhelmed by negative feelings which they came to understand as being about gender incongruence and looked to alleviate these feelings through a gender transition. The second superordinate theme was working out who I am which had two subordinate themes: the centrality of different identities and needs and thinking about gender. This theme described how young people and their parents focused on different needs; while young people more often focused on their gender-related needs, parents focused on autism-related needs. We conclude that young people and parents may have different perspectives and priorities when it comes to meeting the needs of autistic young people who experience gender dysphoria.