bluuebunny/crossref_metadata_2025_split huggingface dataset:
Load-Velocity Relationship Variables to Assess the Maximal Neuromuscular Capacities During the Back-Squat Exercise
Authors: Pérez-Castilla Alejandro , Jukic Ivan , Janicijevic Danica , Akyildiz Zeki , Senturk Deniz , García-Ramos Amador 
Published: February 2022

Background: The relationship between the external load lifted and movement velocity can be modeled by a simple linear regression, and the variables derived from the load-velocity (L-V) relationship were recently used to estimate the maximal neuromuscular capacities during 2 variants of the back-squat exercise. Hypothesis: The L-V relationship variables will be highly reliable and will be highly associated with the traditional tests commonly used to evaluate the maximal force and power. Study Design: Twenty-four male wrestlers performed 5 testing sessions (a 1-repetition maximum [1RM] session, and 4 experimental sessions [2 with the concentric-only back-squat and 2 with the eccentric-concentric back-squat]). Each experimental session consisted of performing 3 repetitions against 5 loads (45%-55%-65%-75%-85% of the 1RM), followed by single 1RM attempts. Level of Evidence: Level 3. Methods: Individual L-V relationships were modeled from the mean velocity collected under all loading conditions from which the following 3 variables were calculated: load-axis intercept ( L0), velocity-axis intercept ( v0), and area under the line ( Aline = L0· v0/2). The back-squat 1RM strength and the maximum power determined as the apex of the power-velocity relationship ( Pmax) were also determined as traditional measures of maximal force and power capacities, respectively. Results: The between-session reliability was high for the Aline (coefficient of variation [CV] range = 2.58%-4.37%; intraclass correlation coefficient [ICC] range = 0.98-0.99) and generally acceptable for L0 and v0 (CV range = 5.08%-9.01%; ICC range = 0.45-0.96). Regarding the concurrent validity, the correlations were very large between L0 and the 1RM strength ( rrange = 0.87-0.88) and nearly perfect between Aline and Pmax ( r = 0.98-0.99). Conclusion: The load-velocity relationship variables can be obtained with a high reliability ( L0, v0, and Aline) and validity ( L0 and Aline) during the back-squat exercise. Clinical Relevance: The load-velocity relationship modeling represents a quick and simple procedure to estimate the maximal neuromuscular capacities of lower-body muscles.
Identification of Hub Genes and Pathways Associated with Oxidative Stress of Cartilage in Osteonecrosis of Femoral Head Using Bioinformatics Analysis
Authors: Shi Wei , Zhang Xinglong , Xu Chunlei , Pang Ran , Fan Zhenqi , Wan Xin , Jiang Zhaohui , Li Hui , Li Zhijun , Zhang Huafeng 
Published: February 2022

Objective This study aimed to identify the hub genes and pathways of genes related to oxidative stress of cartilage in osteonecrosis of femoral head (ONFH), and to predict the transcription factors of the hub genes. Methods The GSE74089 was obtained from the Gene Expression Omnibus (GEO) database, including 4 necrotic tissues and 4 normal tissues, and the differentially expressed genes (DEGs) were identified by limma package in R language. Simultaneously, we searched for the genes related to oxidative stress in the Gene Ontology (GO) database. GO and signaling pathways analysis were performed using DAVID, Metascape, and GSEA. Protein-protein interaction (PPI) network was constructed using the STRING database, and the Degree algorithm of Cytoscape software was used to screen for hub genes. Finally, the NetworkAnalyst web tool was used to find the hub genes’ transcriptional factors (TFs). Results In total, 440 oxidative stress–related genes were found in GSE74089 and GO database, and 88 of them were significantly differentially expressed. These genes were mainly involved in several signaling pathways, such as MAPK signaling pathway, PI3K-AKT-mTOR signaling pathway, FOXO signaling pathway. The top 10 hub genes were JUN, FOXO3, CASP3, JAK2, RELA, EZH2, ABL1, PTGS2, FBXW7, MCL1. Besides, TFAP2A, GATA2, SP1, and E2F1 may be the key regulatory factors of hub genes. Conclusions We identified some hub genes and signaling pathways associated with oxidative stress in ONFH through a series of bioinformatics analyses.
Outcomes of Single-Stage Versus Staged Treatment of Osteochondral Lesions in Patients With Chronic Lateral Ankle Instability: A Prospective Randomized Study
Authors: Wei Yu , Song Jianing , Yun Xing , Zhang Zhuo , Qi Wei , Wei Min 
Published: February 2022

Background: There is controversy about whether treatment of chronic lateral ankle instability (CLAI) with osteochondral lesions of the talus (OLT) can be performed concurrently. Purpose: To investigate the midterm results of arthroscopic treatment of CLAI combined with OLT in different surgical settings. It was hypothesized that the outcomes of treating both injuries at the same time would not be inferior to those of staged surgery. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: Included were 103 patients with both CLAI and OLT who underwent arthroscopic microfracture surgery and an open, modified Broström-Gould procedure for ligament repair from January 2015 to December 2016. The patients were assigned randomly to a staged group (51 patients) and a single-stage group (52 patients). The staged group underwent arthroscopic debridement of the OLT and microfracture, then rehabilitation for 4 to 6 months before undergoing modified Broström-Gould ligament repair. The single-stage group underwent both procedures simultaneously. Clinical evaluations were performed on the day before surgery and at 12-month, 24-month, and final follow-up periods using the Karlsson-Peterson score, American Orthopaedic Foot & Ankle Society (AOFAS) score, and pain visual analog scale. The Karlsson-Peterson score at 24 months postoperatively was considered the primary outcome. The predefined noninferiority margin for the primary outcome was −5 points. Results: At the final follow-up, 50 patients in the single-stage group and 48 patients in the staged group completed the study. The median lesion size was 0.72 cm2 (interquartile range [IQR], 0.5-1.12 cm2) in the single-stage group and 0.84 cm2 (IQR, 0.7-1.05 cm2) in the staged group. At 12-month follow-up, the single-stage group had a significantly higher median Karlsson-Peterson score (79 [IQR, 70-85] vs 75 [IQR 65-80] for staged; P = .024) and median AOFAS score (85 [IQR, 76-89] vs 79.5 [IQR, 70-87] for staged; P = .045). At 24-month follow-up, the median difference in the Karlsson-Peterson score for single-stage versus staged surgery was 2 points (95% CI, −2 to 5 points), and the confidence interval was greater than the predefined value. Conclusion: At midterm follow-up, there was no clinical difference between single-stage versus staged surgery to treat CLAI with OLT. Single-stage surgery achieved better clinical outcomes than staged surgery at short-term follow-up.
“Something Tells Me I Can’t Do That No More”: Experiences With Real-Time Glucose and Activity Monitoring Among Underserved Black Women With Type 2 Diabetes
Authors: Fritschi Cynthia , Kim Min Jung , Srimoragot Manassawee , Jun Jeehye , Sanchez Lidia Emily , Sharp Lisa K. 
Published: February 2022

Purpose The purpose of the study was to explore self-regulation skills with real-time activity and glucose monitoring among Black women with type 2 diabetes (T2DM). Methods A small acceptability trial was conducted using technology (continuous glucose monitors and Fitbit) to facilitate core behaviors associated with self-regulation (self-monitoring/assessment, learning, mental contrasting [comparing current values with goal values], and goal setting/review). Participants were given continuous glucose monitors and Fitbit activity trackers for self-monitoring of blood glucose and activity. Two sessions of group diabetes education were also offered. Following the intervention, semistructured interviews and subsequent content analyses were conducted to explore how the women’s experiences reflected certain self-regulation behaviors. Results Eight underserved Black women with non-insulin-requiring T2DM were included (age = 68 ± 5.2 years; A1C = 6.6% ± 1.1%; 15.3 ± 7.2 years since diagnosis). Content analysis revealed themes that were consistent with core self-regulation behaviors: experiential learning through self-monitoring, mental contrasting, and impact on behavior (actual behavior change and motivation to change behavior). Conclusions With use of real-time glucose and activity monitoring, underserved Black women with T2DM described how they used the data from the devices to make choices about eating and activity behaviors.
Leriche syndrome diagnosed due to polytrauma: a case report
Authors: Yoshimura Genki , Kamidani Ryo , Miura Tomotaka , Oiwa Hideaki , Mizuno Yosuke , Yasuda Ryu , Kitagawa Yuichiro , Fukuta Tetsuya , Miyake Takahito , Okamoto Haruka , Kanda Norihide , Doi Tomoaki , Okada Hideshi , Yoshida Takahiro , Yoshida Shozo , Ogura Shinji 
Published: February 2022

Abstract
Background
Leriche syndrome is caused by atherosclerosis and is often characterized by symptoms such as intermittent claudication and numbness and coldness of the lower limbs. Its exact prevalence and incidence are unknown because it is a rare disease. We report a case of Leriche syndrome diagnosed incidentally on trauma pan-scan computed tomography (CT).

Case presentation
A 61-year-old Asian male was driving a passenger car and had a head-on collision with a dump truck that required an emergency call. The patient was transported to our hospital in a doctor’s helicopter. Physical examination revealed the following vital signs: respiratory rate, 23 breaths per min; SpO2, 98% under a 10-L administration mask; pulse rate, 133 beats per min; blood pressure, 142/128 mmHg; Focused Assessment with Sonography for Trauma, positive; Glasgow Coma Scale assessment, E3V5M6; and body temperature, 35.9 °C.
Trauma pan-scan CT showed bilateral mandibular fractures, bilateral multiple rib fractures, bilateral pneumothorax, sternal fractures, hematoma around thoracic spine, small bowel perforation, mesenteric injury, right clavicle fracture, right ankle debridement injury, and thrombotic occlusion from just above the abdominal aortic bifurcation to the bilateral common iliac arteries. Although thrombotic occlusion needed to be differentiated from traumatic aortic injury, the presence of collateral blood vessels led to the diagnosis of Leriche syndrome, and conservative treatment was performed.
Damage control surgery was required for the small bowel injuries. From the second day of admission, the patient was treated with continuous intravenous heparin and prostaglandin preparations. However, impaired blood flow and reperfusion injury in the right lower extremity progressed. On the fifth day of admission, right thigh amputation was performed. The patient required renal replacement therapy for 2 weeks starting from the third day of admission.

Conclusions
In this case, conservative therapy was initially chosen for Leriche syndrome. However, the complex factors in the acute phase of trauma led to development of hemorrhagic necrosis, requiring amputation of the lower extremity. Our findings indicate the need to carefully consider the unique factors affecting Leriche syndrome patients when considering treatment indications and choices for trauma.
Computing strategies for multi-population genomic evaluation
Authors: Legarra Andrés , González-Diéguez David , Vitezica Zulma G. 
Published: February 2022

Abstract
Background
Multiple breed evaluation using genomic prediction includes the use of data from multiple populations, or from parental breeds and crosses, and is expected to lead to better genomic predictions. Increased complexity comes from the need to fit non-additive effects such as dominance and/or genotype-by-environment interactions. In these models, marker effects (and breeding values) are modelled as correlated between breeds, which leads to multiple trait formulations that are based either on markers [single nucleotide polymorphism best linear unbiased prediction (SNP-BLUP)] or on individuals [genomic(G)BLUP)]. As an alternative, we propose the use of generalized least squares (GLS) followed by backsolving of marker effects using selection index (SI) theory.

Results
All investigated options have advantages and inconveniences. The SNP-BLUP yields marker effects directly, which are useful for indirect prediction and for planned matings, but is very large in number of equations and is structured in dense and sparse blocks that do not allow for simple solving. GBLUP uses a multiple trait formulation and is very general, but results in many equations that are not used, which increase memory needs, and is also structured in dense and sparse blocks. An alternative formulation of GBLUP is more compact but requires tailored programming. The alternative of solving by GLS + SI is the least consuming, both in number of operations and in memory, and it uses only single dense blocks. However, it requires dedicated programming. Computational complexity problems are exacerbated when more than additive effects are fitted, e.g. dominance effects or genotype x environment interactions.

Conclusions
As multi-breed predictions become more frequent and non-additive effects are more often included, standard equations for genomic prediction based on Henderson’s mixed model equations become less practical and may need to be replaced by more efficient (although less general) approaches such as the GLS + SI approach proposed here.
Cross-species transcriptomic analyses reveals common and opposite responses in Arabidopsis, rice and barley following oxidative stress and hormone treatment
Authors: Hartmann Andreas , Berkowitz Oliver , Whelan James , Narsai Reena 
Published: February 2022

Abstract
Background
For translational genomics, a roadmap is needed to know the molecular similarities or differences between species, such as model species and crop species. This knowledge is invaluable for the selection of target genes and pathways to alter downstream in response to the same stimuli. Here, the transcriptomic responses to six treatments including hormones (abscisic acid - ABA and salicylic acid - SA); treatments that cause oxidative stress (3-amino-1,2,4-triazole - 3AT, methyl viologen - MV); inhibit respiration (antimycin A - AA) or induce genetic damage (ultraviolet radiation -UV) were analysed and compared between Arabidopsis (Arabidopsis thaliana), barley (Hordeum vulgare) and rice (Oryza sativa).

Results
Common and opposite responses were identified between species, with the number of differentially expressed genes (DEGs) varying greatly between treatments and species. At least 70% of DEGs overlapped with at least one other treatment within a species, indicating overlapping response networks. Remarkably, 15 to 34% of orthologous DEGs showed opposite responses between species, indicating diversity in responses, despite orthology. Orthologous DEGs with common responses to multiple treatments across the three species were correlated with experimental data showing the functional importance of these genes in biotic/abiotic stress responses. The mitochondrial dysfunction response was revealed to be highly conserved in all three species in terms of responsive genes and regulation via the mitochondrial dysfunction element.

Conclusions
The orthologous DEGs that showed a common response between species indicate conserved transcriptomic responses of these pathways between species. However, many genes, including prominent salt-stress responsive genes, were oppositely responsive in multiple-stresses, highlighting fundamental differences in the responses and regulation of these genes between species. This work provides a resource for translation of knowledge or functions between species.
Application of the PDCA cycle for standardized nursing management in sepsis bundles
Authors: Liu Chunxia , Liu Yun , Tian Yiqing , Zhang Kun , Hao Guizhen , Shen Limin , Du Quansheng 
Published: February 2022

Abstract
Background
To explore the application effect of plan, do, check and action circulation management mode in improving the compliance of sepsis bundle treatment.

Methods
113 patients with sepsis admitted from January 1 to December 31, 2018 were selected as the control group, and the bundle treatment measures of sepsis were routinely implemented. The above treatment measures were completed within 6 h. 113 patients with sepsis admitted from January 1 to December 31, 2019 were selected as the study group. All clinical staff took the same measures as the control group, supplemented by PDCA cycle management. Objective to compare the changes of compliance of clinical staff to sepsis bundle treatment before and after the implementation of PDCA cycle management.

Results
Compared with the control group, the study group achieved the completion rate of sepsis bundle treatment in 1 h from 66.4 to 81.4%, the completion rate in 3 h from 77.0 to 89.4%, and the completion rate in 6 h from 82.3 to 95.6%. The difference was statistically significant (P < 0.05 for all).

Conclusions
The implementation of PDCA cycle management mode can effectively improve the compliance of clinical staff to the bundle treatment of sepsis, improve the treatment efficiency of sepsis, and improve the quality of medical care.
Indicators of suboptimal response to anti-tumor necrosis factor therapy in patients from China with inflammatory bowel disease: results from the EXPLORE study
Authors: Li Ji , Liu Zhanju , Hu Pinjin , Wen Zhonghui , Cao Qian , Zou Xiaoping , Chen Yan , Wang Yingde , Zhong Jie , Shen Xizhong , Demuth Dirk , Fadeeva Olga , Xie Li , Chen Jun , Qian Jiaming 
Published: February 2022

Abstract
Background
Prevalence of inflammatory bowel disease (IBD) is increasing in China. The EXPLORE study evaluated the incidence and indicators of suboptimal responses to first-line anti-tumor necrosis factor (TNF) in patients with ulcerative colitis (UC) or Crohn’s disease (CD). We present results for the mainland China subgroup.

Methods
A retrospective chart review was performed in adults with IBD at 10 centers in mainland China who initiated anti-TNF therapy between 01 March 2010 and 01 March 2015. The cumulative incidence of suboptimal response to first-line anti-TNF therapy was assessed over 24 months using the Kaplan–Meier method. Indicators of suboptimal response were: dose escalation, discontinuation, augmentation with non-biologic therapy, or IBD-related surgery/hospitalization. At site initiation, a survey was conducted with participating physicians to identify barriers to anti-TNF use.

Results
Of 287 patients (72% male) examined, 16/35 (45.7%) with UC and 123/252 (48.8%) with CD experienced a suboptimal response to first-line anti-TNF therapy at any point during the observation period (median 27.6 and 40.0 months, respectively). At 1 and 2 years post anti-TNF initiation, the cumulative incidence of suboptimal response was 51.4% and 75.7% for UC and 45.4% and 57.0% for CD, respectively. Median time to first suboptimal response was 7.2 months for UC and 14.3 months for CD. The most frequent indicator of suboptimal response was discontinuation of anti-TNF therapy (9/16, 56.3%) for UC and IBD-related hospitalization for CD (69/123, 56.1%) followed by augmentation with non-biologic therapy for both cohorts (5/16, 31.3% for UC and 28/123, 22.8% for CD). Dose escalation was the least frequent indicator of suboptimal response to anti-TNF therapy (CD: 4/123, 3.3%; UC: not cited as an indicator). The cumulative incidence of suboptimal response within 4 months of first-line anti-TNF therapy (primary non-response) was over 30% in both cohorts. Financial reasons and reimbursement were identified by surveyed physicians as the most common barriers to prescribing an anti-TNF therapy.

Conclusions
Over one-half of patients with IBD are at risk of experiencing a suboptimal response to first-line anti-TNF therapy at 2 years post-initiation in China. This study highlights a substantial unmet need associated with anti-TNF therapies in China. (Clinicaltrials.gov identifier: NCT03090139).
Physical activity level and associated factors among adult HIV patients in Ethiopia
Authors: Tegene Yadessa , Mengesha Selamawit , van der Starre Caroline , Lako Stephanie , Toma Alemayehu , Spigt Mark 
Published: February 2022

Abstract
Background
People living with HIV, who take antiretroviral therapy (ART), often enjoy long and healthy lives, but this therapy has well known metabolic adverse effects. Physical activity is found to be an important factor in improving these physiological parameters. This study aimed to determine physical activity level and associated factors among HIV patients in Ethiopia.

Methods
An institutional based cross sectional study was conducted from May to June 2019. We selected a total of 422 adult HIV patients, attending antiretroviral therapy clinics in three selected hospitals in Southern Ethiopia. Data were collected at routine care consultations by nine trained nurses using a pre-tested structured questionnaire. The level of physical activity was measured by the international physical activity questionnaire (IPAQ).

Result
The mean age of participants was 38.7 ± 9.13 years. Of the participants, 68% were physically inactive, with a higher proportion of inactive women (74%) than men (61%) [(AOR = 1.64, 95% CI (1.07, 2.53)]. In addition, urban vs. rural residents [(AOR = 2.57, 95% CI (1.16, 5.72)] and patients who were on ART for ≥ 24 months [(AOR = 1.88, 95% CI (1.15, 3.08)] had higher odds of having a low physical activity level.

Conclusion
Most people living with HIV and receiving ART have low physical activity levels. Especially female and urban living patients and those with longer treatment duration have low levels of physical activity. More insight is needed on the reasons for physical inactivity among HIV patients and physical activity programs for HIV patients in low-income countries need to be developed.