bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment of an endoplasmic reticulum stress-associated lncRNAs model to predict prognosis and immunological characteristics in hepatocellular carcinoma
Authors: Zhu Chunfu , Shen Xingyuan , Yang Zhen 
Published: April 2022

Abstract
Background: The endoplasmic reticulum stress (ERS) and unfolded protein response (UPR) pathways play an essential role in the pathophysiology of hepatocellular carcinoma, and activation of the URP pathway is strongly associated with tumor growth. However, the function of endoplasmic reticulum stress (ERS)-associated LncRNAs in hepatocellular cancer is less recognized.Methods: We have used TCGA to obtain clinical and transcriptome data for hepatocellular carcinoma patients and the GSEA molecular signature database to get the Endoplasmic reticulum stress (ERS) gene. Risk models for ERS-associated lncRNAs were built using univariate Cox regression study, LASSO-regression study, and multivariate Cox regression study. Subsequent studies included Kaplan-Meier, multi-exponential ROC curve, GSEA, immune-infiltration study, time-dependent ROC curve. We used consensus clustering study to discover novel subgroups of hepatocellular carcinomas in accordance with transcriptome data of ERS-associated lncRNAs in HCC entire samples.Results: To construct the risk model, we chose six ERS-associated lncRNAs from the HCC training samples (containingMKLN1-AS, LINC01224, AL590705.3, AC008622.2, AC145207.5, and AC026412.3). Calculate the risk score for each HCC patient in accordance with the above 6 lncRNAs, patients with HCC were assigned into the groups at a high risk and a low risk. The overall survival rate of patients in the group at a high risk was lower than that of patients in the group at a low risk. In addition, the group at a high risk exhibited a higher infiltration of immune cells. Sensitivity to various chemotherapeutic drugs in the groups at a high risk and a low risk was studied. Our risk model was an independent prognostic factor according to independent predictive study. The risk model high prediction capacity for HCC prognosis was further confirmed using ROC study.Conclusions: In this article, we created an ERS-associated lncRNAs risk model to help prognostic diagnosis and personalized therapy in Hepatocellular carcinoma.
2D Hexagonal Yttrium Doped SnO2 Nanoplatelets for Photocatalytic Degradation
Authors: Vallimeena S , Helina B 
Published: April 2022

Abstract
In this work, two-dimensional hexagonal nanoplatelets were analyzed through a simple morphological and structural evolutions. XRD analysis of SnO2 and Y doped SnO2 has revealed a tetragonal structure and photoluminescence spectra exhibited a visible emission broadband peak around 464 nm and 528 nm. SnO2: Y (7 wt.%) photoluminescence spectra confirm the higher charge separation and which impede the electron-hole recombination. It has been shown that hexagonal SnO2:Y (7 wt.%) nanoplatelets perform better in photocatalytic degradation than conventional spherical nanoparticles. EIS measurements were performed to investigate the charge carrier movement of both undoped and Y doped SnO2 NPs. Our study is the first to illustrate the two-dimensional morphology of SnO2:Y (7 wt.%) hexagonal nanoplatelets and their application integration of photocatalytic materials.
Hidden in the Labyrinth: Visuo-spatial Attention Deficit in Children with Developmental Dyslexia
Authors: Franceschini Sandro , Bertoni Sara , Puccio Giovanna , Gori Simone , Termine Cristiano , Facoetti Andrea 
Published: April 2022

Abstract
Although developmental reading disorders (developmental dyslexia) have been mainly associated with auditory-phonological deficits, recent longitudinal and training studies have shown a possible causal role of visuo-attentional skills in reading acquisition. Indeed, visuo-attentional mechanisms could be involved in the orthographic processing of the letter string and the graphemic parsing that precede the grapheme-to-phoneme mapping. Here, we used a simple paper-and-pencil task composed of three labyrinths to measure visuo-spatial attention in a large sample of primary school children (n = 398). In comparison to visual search tasks requiring visual working memory, our labyrinth task mainly measures distributed and focused visuo-spatial attention, also controlling for sensorimotor learning. Compared to typical readers (n = 340), children with reading difficulties (n = 58) showed clear visuo-spatial attention impairments that appear not linked to motor coordination and procedural learning skills implicated in this paper and pencil task. Since visual attention is dysfunctional in about 40% of the children with reading difficulties, an efficient reading remediation program should integrate both auditory-phonological and visuo-attentional interventions.
A novel alternating second-generation cryoballoon or radiofrequency catheter ablation technique strategy for repeat ablation in patients with recurrent atrial fibrillation: A two-year follow-up outcome
Authors: Tang Qing-hui , Guo Xiao-Gang , Ma Jian 
Published: April 2022

Abstract
Background
Pulmonary vein (PV) reconnection after radiofrequency ablation (RFC) or 2nd generation cryoballoon (CB) pulmonary vein isolation (PVI) is common.
Method
We report a single-center experience of 156 patients who underwent an alternating redo procedure-ablation strategy for recurrent atrial fibrillation (AF) after a failed index RFC or CB procedure. During the redo procedure, alternating ablation technique was applied in a reverse sequence: RFC was applied for redo ablation in 60 patients with failed index CB ablation(CB-RFC-redo); 2nd generation CB was used for redo ablation in 96 patients after failed index RFC ablation (RFC-CB redo);
Results
During the redo procedure, the proportion of patients with PV reconnection was lower after index CB PVI procedure compared with the proportion of patients after index RFC PVI (88.3% versus 98.9%, p = 0.01). Additionally, 82.8% of all PVs and left common trunks PV (CTs) isolated by index RFC were reconnected, compared with 42% PVs reconnected after index CB PVI (p = 0.005). A mean number of 1.50 ± 0.8 PVs /patient were reconnected after index CB PVI, compared with 3.36 ± 0.9 PVs /patient after index RFC PVI (p = 0.001). Patients after index RFC PVI frequently presented with ≥ 3 reconnected PVs, compared with index CB PVI(70.8% vs 10%, p < 0.001). A total of 60 patients after index CB PVI underwent RFC-redo ablation, and 96 patients after index RFC PVI underwent CB-redo ablation. At a two year follow-up, 43 patients (27.6%) developed recurrence after redo ablation, with a similar AF- free outcome (CB-RFC redo:73.3% vs RFC-CB redo: 71.9%, p = 0.873). In the multivariate analysis, persistent AF (HR = 2.107, 95% CI: 1.085–4.091, p = 0.028) and early AF recurrence after the initial ablation (HR = 2.431, 95% CI: 1.279–4.618, p = 0.007) were independent predictors of AF recurrence after repeat ablation.
Conclusions
The extent and distribution of PV reconnections were different after index RFC and CB PVI procedures. Alternating CB or RFC ablation technique strategy is effective with a similar long-term outcome, and it may be an appropriate option for repeated AF ablation regardless of index ablation technique used.
An Optimization of Outpatients’ Waiting Time and Health-related Risks
Authors: Onoja Anthony , Ogundare Oluwabunmi Chidinma , Tejuoso Funso Emmanuel 
Published: April 2022

Abstract
The study of optimal queuing systems in healthcare is crucial at such a time as this to help decongest the system, and minimize financial and health-related risks associated with long waiting queues. This study examined a queuing system at an outpatient hospital clinic post intending to minimize waiting time in association with financial cost and healthcare-related risks. We observed the queuing system using the sampling survey information of 200 outpatients that visited the clinic for 4 weeks. We used the initial queuing ground truth parameters as the baseline scenario and further simulated 4 other queuing scenarios using the TORA optimization software. We calculated the total expected cost associated with the server(s) (Doctors) and the patients while in the queuing system for each scenario. We further discretize their health-related complications and calculated the incidence rate of the patients while in the queuing system to evaluate their health-related risks. The findings of our study showed that the system utilization, optimal expected total cost, health-related risks (risk of discomfort and illness/infections developed while in the queue), and waiting time are optimal at the hospital clinic with 5 severs (doctors). The contribution of this study arose from the incorporation of health-related risks incidence that patients could develop while in the queuing system.
Examining Research Productivity in Medical School and Dermatology Residency: A Cross-Sectional Study
Authors: Gupta Neha , Tamashumas Nina L , Ramanathan Diya , Erickson Kayley , Xiang Laura , Scott Jeffrey F 
Published: April 2022

Abstract
Research productivity is one criterion used by residency programs to evaluate the academic qualifications of prospective applicants. Our objective was to examine individuals’ research productivity in dermatology residency compared to medical school. A cohort of dermatology residents who graduated from an Accreditation Council for Graduate Medical Education (ACGME) certified Dermatology program in 2019 or 2020. An author search was conducted to identify author publications. Author number, journal name, impact factor, study type, and publication date were collected. Publications were characterized as pre-residency publications (PRPs) if published during intern year, medical school graduating year, or the year before graduating year. Publications were residency publications (RPs) if published during residency. A Wilcoxon signed-rank test was used to compare the average number of PRPs and RPs between individuals. Secondary outcomes were compared using chi-square and t-tests. 5,5159 publications were collected. There was no difference in mean number of PRPs and RPs. However, PRPs were more likely to be first author publications and RPs were more likely to be case reports. Both PRPs and RPs were generally published in the same journals. The differences in PRPs and RPs may stem from changes in mentorship/sponsorship roles during training. Our findings add to the literature on PRPs. Future research should examine continued trends of publications in residency and fellowship.
Mandatory Vaccination Against COVID-19: Twitter Poll Analysis on Public Health Opinion
Authors: Ritschl Valentin , Eibensteiner Fabian , Mosor Erika , Omara Maisa , Sperl Lisa , Nawaz Faisal A , Siva Sai Chandragiri , Cenanovic Merisa , Devkota Hari Prasad , Hribersek Mojca , De Ronita , Klager Elisabeth , Schaden Eva , Kletecka-Pulker Maria , Völkl-Kernstock Sabine , Willschke Harald , Aufricht Christoph , Atanasov Atanas G , Stamm Tanja 
Published: April 2022

Background
On January 30, 2020, the World Health Organization Emergency Committee declared the rapid worldwide spread of COVID-19 a global health emergency. By December 2020, the safety and efficacy of the first COVID-19 vaccines had been demonstrated. However, international vaccination coverage rates have remained below expectations (in Europe at the time of manuscript submission). Controversial mandatory vaccination is currently being discussed and has already been introduced in some countries (Austria, Greece, and Italy). We used the Twitter survey system as a viable method to quickly and comprehensively gather international public health insights on mandatory vaccination against COVID-19.

Objective
The purpose of this study was to better understand the public’s perception of mandatory COVID-19 vaccination in real time using Twitter polls.

Methods
Two Twitter polls were developed (in the English language) to seek the public’s opinion on the possibility of mandatory vaccination. The polls were pinned to the Digital Health and Patient Safety Platform’s (based in Vienna, Austria) Twitter timeline for 1 week in mid-November 2021, 3 days after the official public announcement of mandatory COVID-19 vaccination in Austria. Twitter users were asked to participate and retweet the polls to reach the largest possible audience.

Results
Our Twitter polls revealed two extremes on the topic of mandatory vaccination against COVID-19. Almost half of the 2545 respondents (n=1246, 49%) favor mandatory vaccination, at least in certain areas. This attitude contrasts with the 45.7% (n=1162) who categorically reject mandatory vaccination. Over one-quarter (n=621, 26.3%) of participating Twitter users said they would never get vaccinated, as reflected by the current Western European and North American vaccination coverage rate. Concatenating interpretation of these two polls should be done cautiously as participating populations might substantially differ.

Conclusions
Mandatory vaccination against COVID-19 (in at least certain areas) is favored by less than 50%, whereas it is opposed by almost half of the surveyed Twitter users. Since (social) media strongly influences public perceptions and views, and social media discussions and surveys are specifically susceptible to the “echo chamber effect,” the results should be interpreted as a momentary snapshot. Therefore, the results of this study need to be complemented by long-term surveys to maintain their validity.
#BingeDrinking—Using Social Media to Understand College Binge Drinking: Qualitative Study
Authors: Cirillo Madison N , Halbert Jennifer P , Smith Jessica Gomez , Alamiri Nour Sami , Ingersoll Karen S 
Published: April 2022

BackgroundHazardous drinking among college students persists, despite ongoing university alcohol education and alcohol intervention programs. College students often post comments or pictures of drinking episodes on social media platforms.ObjectiveThis study aimed to understand one university’s student attitudes toward alcohol use by examining student posts about drinking on social media platforms and to identify opportunities to reduce alcohol-related harm and inform novel alcohol interventions.MethodsWe analyzed social media posts from 7 social media platforms using qualitative inductive coding based on grounded theory to identify the contexts of student drinking and the attitudes and behaviors of students and peers during drinking episodes. We reviewed publicly available social media posts that referenced alcohol, collaborating with undergraduate students to select their most used platforms and develop locally relevant search terms; all posts in our data set were generated by students associated with a specific university. From the codes, we derived themes about student culture regarding alcohol use.ResultsIn total, 1151 social media posts were included in this study. These included 809 Twitter tweets, 113 Instagram posts, 100 Greekrank posts, 64 Reddit posts, 34 College Confidential posts, 23 Facebook posts, and 8 YouTube posts. Posts included both implicit and explicit portrayals of alcohol use. Across all types of posts reviewed, positive drinking attitudes were most common, followed by negative and then neutral attitudes, but valence varied by platform. Posts that portrayed drinking positively received positive peer feedback and indicate that drinking is viewed by students as an essential and positive part of university student culture.ConclusionsSocial media provide a real-time picture of students’ behavior during their own and others’ heavy drinking. Posts portray heavy drinking as a normal part of student culture, reinforced by peers’ positive feedback on posts. Interventions for college drinking should help students manage alcohol intake in real time, provide safety information during alcohol use episodes, and raise student awareness of web-based privacy concerns and reputation management. Additional interventions for students, alumni, and parents are needed to address positive attitudes about and traditions of drinking.
Relasi Kuasa Elit Lokal Dan Pemerintah Lokal Dalam Penangan Konflik Sosial Paska Pilkada Dalam Mendukung Ketahanan Sosial
Authors: Andriyani Lusi , Murod Ma'mun , Sulastri Endang , Gunanto Djoni , Sahrul Muhammad , Andiani Devia 
Published: April 2022

ABSTRACTThe purpose of this study is to examine the relation between the local elite power and the local government following the 2017 regional election of DKI Jakarta (Pilkada). The conflict phenomenon that occurs after the general election is an important issue to study. In line with Pilkada's high-intensity activities in many regions in Indonesia, a study of the power relationships between local elites and the local government is important in order to prevent social conflicts following elections. This research is qualitative research using interview data and secondary data from online media, journals, books and related materials to collect data. The technique of data analysis uses secondary data domain techniques. Results of this study stated that 4.3% of people whose friendship had been damaged by the presidential election in 2014 and 5.7% of their social relations affected the regional head elections in Jakarta in 2017. This will continue to increase if no precautionary measures exist other than handling post-election conflicts, which local political elites and local governments deliberately ignore. ABSTRAKTujuan penelitian ini adalah untuk mengkaji relasi antara kuasa elit lokal dengna pemerintah lokal pasca pemilihan kepala daerah (pilkada) DKI Jakarta tahun 2017. Fenomena konflik yang terjadi setelah pelaksanaan pemilihan umum menjadi isu penting untuk dikaji. Seiring dengan kegiatan pilkada yang dilaksanakan di Indonesia di beberapa daerah dengan intensitas yang tinggi maka penting adanya kajian tentang relasi kuasa elit lokal dan pemerintah lokal dalam pencegahan konflik sosial pasca pemilihan. Penelitian ini merupakan penelitian kualitatif dengan teknik pengambilan data melalui data wawancara dan data sekunder yang berasal dari media online, jurnal, buku dan dokumen terkait. Adapun teknik analisis data menggunakan teknik domain data sekunder. Hasil penelitian ini menyebutkan bahwa terdapat 4,3 persen masyarakat yang hubungan pertemanannya rusak karena pemilihan presiden tahun 2014 dan sebesar 5,7 persen hubungan sosialnya terdampak akibat pemilihan kepala daerah Jakarta tahun 2017. Kondisi tersebut akan semakin meningkat apabila tidak ada tindakan pencegahan selain itu pola penanganan konflik paska pilkada dinilai kurang serius dan sengaja dibiarkan oleh elit politik lokal dan pemerintah lokal.
Peran Spiritual Well-Being Untuk Menumbuhkembangkan Kesehatan Mental Demi Mewujudkan Ketahanan Sosial Pada Masyarakat Korban Konflik Sosial Di Aceh Singkil
Authors: Tumanggor Raja Oloan , Dariyo Agoes 
Published: April 2022

ABSTRACT This study aimed to determined the role of spiritual well-being to developed mental health in order to realized social resilience in the victims of social conflict in Aceh Singkil.. Retrieving of data used questionnaires, namely spiritual well-being, resilience and mental health. In this study involved the number of subjects as many as 300 people who were victims of social conflict in Aceh Singkil. Data analysis using correlation and regression. It was found that there was a significant role for spiritual well-being towards the development of resilience, there was a role of spiritual well-being towards the development of mental health, and there was a role of resilience towards mental health in victims of social conflict. ABSTRAKPenelitian ini bertujuan untuk mengetahui peran spiritual well-being untuk mengembangkan kesehatan mental demi mewujudkan ketahanan sosial pada masyarakat korban konflik sosial Aceh Singkil.Pengambilan data dengan menggunakan kuesioner yaitu spiritual well-being, resiliensi dan kesehatan mental. Penelitian ini melibatkan subjek sebanyak 300 orang yang menjadi korban konflik sosial di Aceh Singkil. Analisis data dengan menggunakan korelasi dan regresi.Ditemukan bahwa ada peran signifikan spiritual well-being terhadap pengembangan resiliensi, ada peran spiritual well-being terhadap pengembangan kesehatan mental, dan ada peran resiliensi terhadap kesehatan mental pada korban konflik sosial.
Model Collaborative Governance dalam Pengelolaan Sampah Plastik Laut Guna Mewujudkan Ketahanan Maritim di Indonesia
Authors: Chotimah Hidayat Chusnul , Iswardhana Muhammad Ridha , Rizky Lucitania 
Published: April 2022

Plastic pollution waste has become one of the world crisis that moves transboundary. Once at sea, plastic waste breaks down into small particles, so-called, microplastics are spread the marine ecosystems. It threatens human health and has harmful economic consequences for the marine sector. Indonesia is the second-largest contributor to the abundance of plastic waste in the ocean which in the same time as an archipelago country which rich in marine products. Indonesia is taking proactive steps as the responsible act for overcoming challenge of marine plastic pollution. So, the maritime environment resilience can be realized through a collaborative governance approach. This study uses a qualitative approach by collecting data from interviews, webinars and literature studies. The results of the study indicate that a collaborative governance approach is crucial to address marine plastic pollution by involving collaborating action from multi-stakeholders, government and non-government actors. Plastic pollution waste could be accomplished by strengthening the role and responsibility of each actor. In the process of collaboration, there are some dialogues, trust between the collaborating actors, commitment to the process of collaboration, shared understanding towards the common idea or goals, and intermediate outcome of collaboration between stakeholders in marine plastic waste management.
Manajemen Laba: Sebuah Studi Literatur
Authors: Manuela Angel , Wulan Ariska Berlian Nur , Septiani Leny , Meiden Carmel 
Published: April 2022

Manajemen laba adalah salah satu praktik yang paling banyak dilakukan dalam bisnis, khususnya bagian akuntansi. Pada tahun 1989 topik ini sudah mulai dibahas, dan masih juga dipelajari sampai sekarang. Pembahasan mengenai manajemen laba bervariasi, salah satunya yaitu mengenai faktor-faktor yang mempengaruhi manajemen laba, seperti good corporate governance (GCG), kualitas audit, ukuran perusahaan, profitabilitas, leverage, financial distress, efektivitas dewan komisaris dan efektivitas komite audit, struktur kepemilikan, kebijakan utang, dan corporate social responsibility (CSR). Karena manajemen laba dapat mengurangi kualitas informasi keuangan maka mengetahui faktor-faktor yang mempengaruhi praktik ini merupakan hal yang penting agar dapat diberi perhatian lebih dan manajemen laba dapat diminimalisir. Studi ini dilaksanakan dengan cara meninjau 21 penelitian terdahulu yang berkaitan dengan manajemen laba dan menyimpulkan hasil-hasil temuan penelitian-penelitian tersebut. Artikel yang ditinjau berasal dari dalam maupun luar Indonesia dengan rentang waktu publikasi dari tahun 2017-2021. Untuk artikel dalam negeri dipilih yang berindex Sinta (Science and Technology Index), sedangkan rtikel internasional yang digunakan adalah yang berindex Scopus dan/atau Google Scholar. Dari studi literatur ini didapati kesimpulan bahwa faktor-faktor yang berpengaruh pada praktik manajemen laba adalah struktur kepemilikan (kepemilikan manajerial dan institusional), ukuran perusahaan, umur perusahaan, leverage, pertumbuhan penjualan, profitabilitas, kinerja perusahaan, efektivitas dewan komisaris dan komite audit, perencanaan pajak, kualitas audit, kebijakan utang, CSR, arus kas operasional, free cash flow, karakteristik dewan direksi (independensi, diversitas gender, dan dualitas CEO), GCG, debt financing, corporate strategy, dan cash holding.