bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Neighborhood Care Volunteer Training Programs: A Mixed‐Methods Study
Authors: Kung Pen‐Chen , Sung Ya‐Li , Wong May‐Kuen Alice , Liao Yen‐Ting , Chou Yen‐Fang , Huang Huei‐Ling 
Published: January 2025

ABSTRACTObjectiveTo develop and implement a tiered training model for neighborhood caregiving volunteers and to evaluate its impact on participants’ knowledge, behaviors, and attitudes toward caregiving services.Design and MethodsWe employed a mixed‐methods research design. Participants included 32 neighborhood care volunteers and six seed volunteers. The neighborhood volunteer training program comprised three phases: Development (establishing the tiered training structure), Testing (conducting a pilot study), and Promotion (refining the training curriculum and service model, followed by community practice).d This study primarily evaluated the training outcomes of participants in the promotion phase, with additional qualitative interviews to capture the volunteers’ experiences.ResultsQuantitative data analysis showed that graded healthcare training significantly improved volunteers’ caregiving knowledge, self‐efficacy, and perceptual behavior. Course satisfaction was highest with advanced caregiver training, followed by basic caregiver and volunteer caregiver‐instructor training. Qualitative analysis revealed three themes: (1) improved volunteer role effectiveness, (2) positive service experience, and (3) positive, personal understanding of health.ConclusionsProviding progressive training and adequate support for volunteers is crucial. Volunteer trainers or management units should emphasize creating positive experiences for volunteers, fostering their abilities, and promoting their willingness to remain engaged in community health services.
BRISC-Mediated PPM1B-K63 Deubiquitination and Subsequent TGF-β Pathway Activation Promote High-Fat/High-Sucrose Diet–Induced Arterial Stiffness
Authors: Liu Yanan , Li Mengke , Chen Zhipeng , Zuo Min , Bao Kaiwen , Zhao Ziyan , Yan Meng , Bai Yongping , Ai Ding , Wang Hu , Jiang Hongfeng 
Published: January 2025

BACKGROUND:

Metabolic syndrome heightens cardiovascular disease risk primarily through increased arterial stiffness. We previously demonstrated the involvement of YAP (Yes-associated protein) in high-fat/high-sucrose diet (HFHSD)–induced arterial stiffness via modulation of PPM1B (protein phosphatase Mg
2+
/Mn
2+
–dependent 1B)-lysine 63(K63) deubiquitination. In this study, we aimed to elucidate the role and mechanisms underlying PPM1B deubiquitination in HFHSD-induced arterial stiffness.

METHODS:
Enzymes governing PPM1B deubiquitination were identified through small interfering RNA (siRNA) screening and mass spectrometry. Glutathione S-transferase pull-down, coimmunoprecipitation, protein purification, and immunofluorescence were used to explore the mechanism underlying PPM1B deubiquitination. Doppler ultrasound was used to evaluate HFHSD-induced arterial stiffness in mice, and telemetry was used to record pulsatile (systolic and diastolic) blood pressure.

RESULTS:

Smooth muscle cell–specific PPM1B overexpression attenuated HFHSD-induced arterial stiffness in mice in a PPM1B-K326-K63–linked polyubiquitination-dependent manner. Mechanistically, ABRO1 (Abraxas brother 1; a core BRCC36 [BRCA1/BRCA2 (breast cancer type 1/2)–containing complex subunit 36] isopeptidase complex component) directly bound YAP and underwent liquid-liquid phase separation with YAP and PPM1B in a YAP-dependent manner, which in turn promoted PPM1B deubiquitination. Furthermore, smooth muscle cell–specific
Abro1
-knockout mice and
Brcc3
-knockout mice showed attenuated HFHSD-induced arterial stiffness and activation of transforming growth factor-β–Smad (mothers against decapentaplegic homolog) signaling.

CONCLUSIONS:
We elucidated the PPM1B deubiquitination mechanisms and highlighted a potential therapeutic target for metabolic syndrome–related arterial stiffness.
Consistent phenological advancement of Common Toad migration in response to climate change in Flanders, Belgium
Authors: Blomme Ellen , Batsleer Femke , Matheve Hans , Verbelen Dominique , Martel An , Croubels Siska , Pasmans Frank , Bonte Dries 
Published: January 2025

Abstract
Many species use temperature as a cue to time certain life events. Such phenological events can be particularly sensitive to climate change. In amphibians, seasonal migration events between ponds and winter habitats are crucial to ensure reproduction. Therefore, shifts in phenological events – called phenological shifts – can significantly affect the persistence of amphibian populations, especially when induced by climate change. We used citizen science data collected during the spring migration of the Common Toad (Bufo bufo) from 1981 until 2020 to: (i) estimate the phenological shift, (ii) determine consistency of these changes within the studied region, and (iii) relate its temporal variation with changes in temperature. The results revealed an advancement in the peak migration of 3.1 days per decade. This shift was consistent across all populations in Flanders, indicating a regional effect that is most likely due to climate change. This reasoning is supported by the temperature-based model, which indicates that earlier migration occurs in warmer years. Nonetheless, significant local variations persist in the timing of spring migration. Our results highlight the importance of studying in detail the timing of spring migration and its variability, as it may elucidate mechanisms underlying trends in population decline at both national and international scales.
Posterolateral Knee Ligament Reconstruction Using the Arciero Technique Provides Greater Rotational Stability Than the Modified Larson Technique: A Biomechanical Study
Authors: Coppola Christian , Sigloch Maximilian , Hoermann Romed , Schlumberger Michael , Schuster Philipp , Schmoelz Werner , Mayr Raul 
Published: January 2025

Background: It is still unknown if the double–femoral tunnel technique (Arciero [ARC]) provides better stability as compared with the single–femoral tunnel technique (modified Larson [LAR]) in posterolateral corner reconstruction. The ideal angle of fixation of the popliteofibular strand in ARC is also unknown. Hypotheses: The ARC provides greater external rotation (ER) stability than the LAR (hypothesis 1); there is no difference in varus rotation (VR) stability between LAR and ARC (hypothesis 2); and femoral fixation of the popliteofibular strand at 60° during the ARC leads to greater ER stability than fixation at 30° or 90° of knee flexion (hypothesis 3). Study Design: Controlled laboratory study. Methods: Eight fresh-frozen human knees were tested in a knee test bench in 4 states: native, posterolateral deficiency, LAR, and ARC. With the ARC, the popliteofibular strand was fixed at 30°, 60°, and 90° (ARC30, ARC60, ARC90). The order of testing (LAR/ARC) was randomized. A tibial ER and VR torque of 5 N·m was applied at 0°, 30°, 60°, and 90°. Rotation degrees were captured using an ultrasound-based analysis system. Wilcoxon signed rank tests were used to assess statistical significance between paired groups in different states. Results: The ARC and LAR significantly improved VR and ER stability at all flexion angles in comparison with posterolateral deficiency ( P < .05). At 60° and 90°, ARC30 showed significantly greater ER stability in comparison with the LAR (mean ± SD; ARC30 vs LAR at 60°, 21.2°± 5.1° vs 15.4°± 5.6° [ P < .05]; ARC30 vs LAR at 90°, 23.7°± 5.6° vs 16.8°± 6.3° [ P < .05]). At 90°, the LAR showed significantly greater VR instability in comparison with the native state (3.5°± 1.5° vs 2.5°± 1.0°; P = .012), and ARC30 was not significantly different from the native state with respect to VR (2.9°± 1.5° vs 2.5°± 1.0°; P = .327). No significant differences in ER and VR were found among ARC30, ARC60, and ARC90 at any flexion angle ( P≥ .05). Conclusion: The ARC technique provided greater tibial ER stability in comparison with the LAR at higher flexion angles (hypothesis 1 accepted). There were no differences between LAR and ARC in restoring VR stability, except at 90° (hypothesis 2 partly accepted). Different femoral flexion angles for fixation of the popliteofibular strand during the ARC did not show any significant differences in relation to knee stability (hypothesis 3 rejected). Clinical Relevance: Posterolateral corner reconstruction using the ARC technique provides greater ER stability at higher flexion angles than the modified LAR technique.
Leg Dominance Effects During Single- and Dual-Task Modified Balance Error Scoring System Assessment in Collegiate and High School Athletes
Authors: Moran Ryan N. , Stewart Earl Ray , Haller Mason , Ramirez Jonathan 
Published: January 2025

Background: The modified Balance Error Scoring System (mBESS) incorporates nondominant leg stance for a ceiling effect, but that may not be the worse balancing leg. Updated recommendations call for single- and dual-task tandem gait, but limited research has explored these effects on the mBESS. Purposes: To compare mBESS performance between dominant and nondominant legs during single and dual tasks and to determine 1-week test-retest reliability. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 119 intercollegiate, collegiate club, and high school athletes were administered a baseline mBESS battery consisting of performance on both legs and during single and dual task at 2 time points, 1 week apart. Measures consisted of mBESS errors and sway index during counterbalanced single- and dual-task conditions on dominant and nondominant legs. Wilcoxon signed-rank tests were conducted to determine differences in errors and sway index between dominant and nondominant legs and single- and dual-task performance. Spearman correlations were used to measure reliability at 1 week ± 2 days. Results: No differences were observed between nondominant and dominant single-leg errors ( P = .79) and sway index ( P = .98), nor tandem stance errors ( P = .95) and sway index ( P = .86). Greater errors were committed during dual-task single-leg stance ( P = .05) but not on sway index ( P = .69). No differences existed between single and dual tasks on tandem errors ( P = .63) and sway index ( P = .53). Test-retest coefficients were weak to moderate ( rs = −0.009 to 0.368) for normal mBESS errors and fair for sway index ( rs = 0.389 to 0.442) at a 1-week interval. Conclusion: Our study demonstrated that leg dominance does not appear to affect mBESS errors or sway index, indicating that either leg may be used, in the absence of lower extremity injury history or instability. Incorporation of a dual task provides little clinical utility and may not be specific enough to elicit postural control changes on the mBESS, further indicating the use of optional foam conditions or single- and dual-task tandem gait. Caution is needed when using mBESS after a 1-week time point.
Reassessing the roles of oxidative DNA base lesion 8-oxoGua and repair enzyme OGG1 in tumorigenesis
Authors: Wang Jing , Li Chunshuang , Han Jinling , Xue Yaoyao , Zheng Xu , Wang Ruoxi , Radak Zsolt , Nakabeppu Yusaku , Boldogh Istvan , Ba Xueqing 
Published: January 2025

AbstractROS cause multiple forms of DNA damage, and among them, 8-oxoguanine (8-oxoGua), an oxidized product of guanine, is one of the most abundant. If left unrepaired, 8-oxoGua may pair with A instead of C, leading to a mutation of G: C to T: A during DNA replication. 8-Oxoguanine DNA glycosylase 1 (OGG1) is a tailored repair enzyme that recognizes 8-oxoGua in DNA duplex and initiates the base excision repair (BER) pathway to remove the lesion and ensure the fidelity of the genome. The accumulation of genomic 8-oxoGua and the dysfunction of OGG1 is readily linked to mutagenesis, and subsequently aging-related diseases and tumorigenesis; however, the direct experimental evidence has long been lacking. Recently, a series of studies have shown that guanine oxidation in the genome has a conservative bias, with the tendency to occur in the regulatory regions, thus, 8-oxoGua is not only a lesion to be repaired, but also an epigenetic modification. In this regard, OGG1 is a specific reader of this base modification. Substrate recognition and/or excision by OGG1 can cause DNA conformation changes, affect chromatin modifications, thereby modulating the transcription of genes involved in a variety of cellular processes, including inflammation, cell proliferation, differentiation, and apoptosis. Thus, in addition to the potential mutagenicity, 8-oxoGua may contribute to tumor development and progression through the altered gene expression stemming from its epigenetic effects.
The Influence of Study Quality, Age, and Geographic Factors on PCOS Prevalence—A Systematic Review and Meta-analysis
Authors: Amiri Mina , Hatoum Sana , Buyalos Richard P , Sheidaei Ali , Azziz Ricardo 
Published: January 2025

Abstract

Background
Polycystic ovary syndrome (PCOS) is a highly prevalent disorder with substantial burden, yet global epidemiological data remains limited.

Objectives
To estimate the PCOS prevalence globally.

Materials and Methods
We systematically searched PubMed and Embase for PCOS studies in unselected populations through February 2024.

Results
Our study included 88 studies (n = 561 287 women) from 7144 records. The highest PCOS prevalence was identified by the Rotterdam criteria, followed by the Androgen Excess and PCOS Society (AE-PCOS) and the National Institutes of Health (NIH). High-quality studies, as assessed using our newly developed PCOS Epidemiology and Phenotype (PEP) tool, indicated prevalences of 10.89%, 10.61%, and 6.63% using Rotterdam, AE-PCOS, and NIH, respectively. Considering only high-quality studies revealed no significant regional disparities using either NIH [ranging from 5.72% in the Eastern Mediterranean Region (EMR) to 6.90% in the Western Pacific Region (WPR)] or Rotterdam (ranging from 11.15% in South-East Asia to 9.12% in EMR). For AE-PCOS, sufficient data was available only for the WPR region (6.9%). No studies were available in the African Region. A higher PCOS prevalence was observed in adults than adolescents using NIH (8.52% vs 4.44%; P = .01), although the difference diminished when considering only high-quality studies (7.25% vs 4.44%; P = .053). Limited data restricted age-group comparisons using Rotterdam and AE-PCOS.

Conclusion
This systematic review and meta-analysis reveals a trend toward regional variations and age differences across diagnostic criteria. The study results suggest considering study quality using instruments tailored for epidemiological studies in PCOS, such as the PEP tool, when carrying out these types of meta-analyses.
Validation of the Clavien-Dindo classification and Comprehensive Complication Index as measures of morbidity following total hip and knee arthroplasty
Authors: Rele Siddharth , Shadbolt Cade , Schilling Chris , Thuraisingam Sharmala , Trieu Jason , Choong Emma L. P. , Gould Daniel , Taylor Nicholas F. , Dowsey Michelle M. , Choong Peter F. M. 
Published: January 2025

AimsThe Clavien-Dindo (CD) classification and Comprehensive Complication Index (CCI) have been validated primarily among general surgical procedures. To date, the validity of these measures has not been assessed in patients undergoing arthroplasty.MethodsThis retrospective cohort study included patients undergoing primary total hip and knee arthroplasty between April 2013 and December 2019. Complications within 90 days of surgery were graded using the CD classification and converted to CCI. Validity was established by assessing the association between both measures and discharge to inpatient rehabilitation, length of stay, and costs.ResultsAmong 2,884 patients, 414 (14.4%) had an in-hospital complication and 643 (22.3%) had a complication within 90 days. Each increase in CD grade was associated with USD$1,895.48 (95% CI 1,734.77 to 2,056.18) of additional costs, an additional 1.24 days’ length of stay (95% CI 1.15 to 1.33), and 43% (95% CI 26 to 62%) greater odds of discharge to inpatient rehabilitation. Each ten-unit increase in CCI score was associated with USD$1,698.55 (95% CI 1,561.8 to 1,835.3) higher costs, an additional 1.09 days’ length of stay (95% CI 1.02 to 1.17), and 33% (95% CI 19% to 49%) greater odds of discharge to inpatient rehabilitation.ConclusionBoth the CD classification and CCI appear valid and applicable to patients undergoing total joint replacement.Cite this article: Bone Joint J 2025;107-B(1):81–88.
Tight sandstone fluid detection technology based on multi-wave seismic data
Authors: Yutan Dou , Daxing Wang , Mengbo Zhang , Fei Li , Guanghong Du , Yonggang Wang , Yuhua Zhao , Feng Liu , Yan Huang , Jie Zhang , Xiaojie Cui , Ligang Huang , Jun Zhu 
Published: January 2025

Abstract
The SX area of the Ordos Basin in China is characterized by small thickness and considerable lateral variation of the reservoir, and high heterogeneity. It is difficult to identify gas and water by conventional P-wave seismic data without fully utilizing reservoir P-wave and S-wave information. Therefore, this study forms a series of seismic fluid detection technologies based on multi-wave seismic data, including the multi-wave “bright spot” feature analysis, multi-wave amplitude ratio technique, multi-wave amplitude versus offset analysis, multi-wave matched compression correlation analysis, and multi-wave pre-stack simultaneous inversion. The combined application of P- and S-waves facilitates visualized identification of fluids and improves the success rate of seismic prediction of underground gas-bearing features. The multi-wave interpretation technology series for low-permeability lithological gas reservoirs formed in this area has achieved a transformation from qualitative interpretation to quantitative prediction, and from lithological identification to fluid detection. These technologies have achieved significant geological results in the SX area.
Study on sedimentary model of Shanxi Formation – Lower Shihezi Formation in Da 17 well area of Daniudi gas field, Ordos Basin
Authors: Yang Chenyu , Yu Hang , Xie Hui , Peng Shunfeng , Tian Jiangfei , Gao Zhiwu , Luo Tian 
Published: January 2025

Abstract
The Daniudi gas field in the Ordos Basin is a significant area for developing tight sandstone gas reservoirs in China. This study focuses on the Permian Shanxi and Lower Shihezi formations in the Da 17 well area, analyzing sedimentary model through petrological characteristics, physical properties, pore characteristics, and lithofacies characteristics. Findings reveal that the Shanxi Formation belongs to the deltaic plain sedimentary environment, which is divided into distributary channel and inter-channel, and identifies the microfacies of the main distributary channel and the sub-distributary channel. The Lower Shihezi Formation exhibits braided channel sediments, dividing them into channel bar sediments and flood plain sediments, and identifying isolated channel microfacies and superimposed channel microfacies. Analysis shows that sedimentation has an impact on reservoir properties through particle size, lithological characteristics, and sedimentary microfacies. The main distributary channel and superimposed sandbars are favorable microfacies for the formation of gas reservoirs. The porosity of the main diversion channel ranges from 8 to 13%, and the permeability ranges from 0.3 to 0.6 × 10−3 m2. The porosity of the superimposed sandbar ranges from 8 to 15%, with a permeability of 0.3–2.2 × 10−3 m2. This study provides a theoretical foundation advancing tight sandstone gas development in the Daniudi gas field.
Graphitic carbon nitride hybrid thin films for energy conversion: A mini-review on defect activation with different materials
Authors: Acuña Leal Daniel A. , Santiago Ramírez Claudia R. , Ramos Delgado Norma A. , Shaji Sadasivan , Gracia Pinilla Miguel A. 
Published: January 2025

Abstract
In this mini-review, we address the properties of graphitic carbon nitride (g-C3N4) hybrid thin films and their application, with particular attention to the modification of their photocatalytic or photovoltaic properties by the addition of chalcogenide materials, layered semiconductors, or perovskites. The defect states that give rise to active sites for photocatalysis are studied and related to the modification with the different materials. Bulk defects provided by some configurations are also studied. Moreover, the appropriate changes with perovskite materials, or the addition of carbon nitride to perovskites, boost the efficiency and stability of the devices, a subject that is studied in this work. Specific mechanisms of passivation provided by carbon nitride on photovoltaic devices are explained.
Nanoparticles and the treatment of hepatocellular carcinoma
Authors: Zhang Ziyu , Cao Weihua , Li Xinxin , Deng Wen , Jiang Tingting , Wang Shiyu , Yang Liu , Lin Yanjie , Bi Xiaoyue , Lu Yao , Xu Mengjiao , Zhang Lu , Yi Wei , Xie Yao , Li Minghui 
Published: January 2025

Abstract
Currently, liver cancer is the leading cause of cancer-related death worldwide, with a low 5-year survival rate, which will further decrease if advanced metastasis is present. Hepatocellular carcinoma (HCC) is the main type. However, due to the lack of specific symptoms in the early stages, it is more difficult to detect HCC, and many patients would have already been diagnosed with advanced liver cancer. At this point, many treatment methods available at early diagnosis would have become ineffective. Therefore, there is an urgent need for more effective treatment methods for HCC. In recent years, nanoparticles have been used in the treatment of HCC due to their good biocompatibility and other advantages. Different types of nanoparticles are modified to play a role in the treatment of HCC, such as regulating tumor microenvironment, enhancing the activity of drug targeting and killing cancer cells, and reducing systemic side effects. It can significantly improve the therapeutic effect of HCC and bring more hope for the treatment of HCC. In this review, several common nanoparticles are introduced, and their characteristics are described in detail. In addition, the construction of a highly efficient drug delivery system by nanoparticles and the combination of nanoparticle-targeted therapy, chemotherapy, and radiotherapy are reviewed.
Theoretical investigation and sensitivity analysis of non-Newtonian fluid during roll coating process by response surface methodology
Authors: Ali Fateh , Souayeh Basma , Hou Yanren , Usman Muhammad , Bhattacharyya Suvanjan , Sarfraz Muhammad 
Published: January 2025

Abstract
In the current investigation, we propose the analytical and numerical solutions of the Navier–Stokes equation for the reverse roll coating process (RRCP) using a bath of the Sisko fluid model (SFM). A suitable transformation is applied to the partial differential equation-based mathematical model of SFM-RRCP, resulting in a set of nonlinear ordinary differential equations. The perturbation method has been employed to find the analytical solutions for velocity, flow rate, pressure gradient, pressure, and temperature distribution. The Newton–Raphson method has been used to find coating thickness. Furthermore, numerical integration has been applied to compute some mechanical quantities of interest, including power input and roll separation force. Sensitivity analysis is another approach implemented using response surface methods to examine the impacts of velocity ratio and non-Newtonian parameters on coating thickness, power input, and roll separating forces. The residual graphs and contour diagrams are also shown. It has been observed that as the value of non-Newtonian fluid parameters increases, the velocity profile decreases. However, the coating thickness on the web is a decreasing function. Further, it has been observed that separation points moved toward the nip region when the value of the velocity ratio was raised. Moreover, the sensitivity of roll separating forces and power input to input parameters is negative.