bluuebunny/crossref_metadata_2025_split huggingface dataset:
Web‐Based Data to Quantify Meteorological and Geographical Effects on Heat Stroke: Case Study in China
Authors: Han Qinmei , Liu Zhao , Jia Junwen , Anderson Bruce T. , Xu Wei , Shi Peijun 
Published: July 2022

AbstractHeat stroke is a serious heat‐related health outcome that can eventually lead to death. Due to the poor accessibility of heat stroke data, the large‐scale relationship between heat stroke and meteorological factors is still unclear. This work aims to clarify the potential relationship between meteorological variables and heat stroke, and quantify the meteorological threshold that affected the severity of heat stroke. We collected daily heat stroke search index (HSSI) and meteorological data for the period 2013–2020 in 333 Chinese cities to analyze the relationship between meteorological variables and HSSI using correlation analysis and Random forest (RF) model. Temperature and relative humidity (RH) accounted for 62% and 9% of the changes of HSSI, respectively. In China, cases of heat stroke may start to occur when temperature exceeds 36°C and RH exceeds 58%. This threshold was 34.5°C and 79% in the north of China, and 36°C and 48% in the south of China. Compared to RH, the threshold of temperature showed a more evident difference affected by altitude and distance from the ocean, which was 35.5°C in inland cities and 36.5°C in coastal cities; 35.5°C in high‐altitude cities and 36°C in low‐altitude cities. Our findings provide a possible way to analyze the interaction effect of meteorological variables on heat‐related illnesses, and emphasizes the effects of geographical environment. The meteorological threshold quantified in this research can also support policymaker to establish a better meteorological warning system for public health.
Ambient‐Noise Tomography of the Ligurian‐Provence Basin Using the AlpArray Onshore‐Offshore Network: Insights for the Oceanic Domain Structure
Authors: Nouibat A. , Stehly L. , Paul A. , Schwartz S. , Rolland Y. , Dumont T. , Crawford W. C. , Brossier R. ,   Cifalps Team, and AlpArray Working Group
Published: July 2022

AbstractWe derive a three‐dimensional shear‐wave velocity model of the Ligurian‐Provence back‐arc basin (Northwestern Mediterranean Sea) using ocean‐bottom seismometers (AlpArray OBSs) and land stations from permanent and temporary seismic networks. The quality of OBS continuous records is enhanced by a specific processing that reduces instrumental and seabed‐induced noises (transients, tilt, compliance). To further improve the resolution of ambient‐noise tomography in the offshore area, we compute the Rayleigh‐wave part of the Green functions for OBS‐OBS pairs by using onshore stations as virtual sources. 2‐D group‐velocity maps and their uncertainties are computed in the 4–150 s period range by a transdimensional inversion of Rayleigh‐wave travel times. The dispersion data and their uncertainties are inverted for a probabilistic 3‐D shear‐wave velocity model that includes probability densities for Vs and for the depth of layer interfaces. The probabilistic model is refined by a linearized inversion that accounts for the water layer in the Ligurian Sea. Our S‐wave velocity and layer boundary probability models correspond well to a recent, high‐resolution P‐wave velocity cross‐section derived from controlled‐source seismic profiling along the Ligurian‐Provence basin axis. A joint interpretation of the P‐ and S‐wave velocity sections along this profile reveals a thin, anomalous oceanic crust of low P‐wave velocities but high S‐wave velocities, intruded by a gabbroic body. The illuminated part of the upper mantle appears to be devoid of serpentinization.
How Small Slip Surfaces Evolve Into Large Submarine Landslides—Insight From 3D Numerical Modeling
Authors: Zhang W. , Puzrin A. M. 
Published: July 2022

AbstractSubmarine landslides are a major marine geohazard affecting resilience of offshore infrastructure and coastal urban centers. Attention has previously been paid to quantifying post‐failure dynamics of catastrophic submarine debris flows and their consequences. However, pre‐failure initiation and growth of a small slip surface evolving into a large submarine landslide are still less understood. This study aims to explore the physical failure mechanism of submarine landslides initiated from small slip surfaces and to quantify key features of failure evolution. They are achieved by modeling the entire three‐dimensional (3D) landslide evolution, integrating the initiation and growth of slip surface, failure of slab above the slip surface, post‐failure mass movement and re‐deposition of transported sediments, using a novel numerical method. The characteristics of the slip surface growth within a favored layer and the patterns of the slab failure in the overlying layer have been thoroughly discussed. The transition from the pre‐failure slip surface growth to the diverse post‐failure mass movement are first observed and discussed with the 3D geometry effects, revealing the complex cascading mass movement mechanisms. The criterion for unstable growth of a planar slip surface and critical condition for slab failure are proposed. The findings from the study facilitate scientific understanding of the evolution of historic events and help safeguarding offshore developments against submarine landslide recurrence.
Controllable oscillated spin Hall effect of Bessel beam realized by liquid crystal Pancharatnam-Berry phase elements
Authors: Liu Sheng , Qi Shuxia , Li Yanke , Wei Bingyan , Li Peng , Zhao Jianlin 
Published: July 2022

AbstractPancharatnam–Berry (PB) phase has become an effective tool to realize the photonic spin Hall effect (PSHE) in recent years, due to its capacity of enhancing the spin-orbit interaction. Various forms of PSHEs have been proposed by tailoring the PB phase of light, however, the propagation trajectory control of the separated spin states has not been reported. In this paper, we realize the oscillated spin-dependent separation by using the well-designed PB phase optical elements based on the transverse-to-longitudinal mapping of Bessel beams. Two typical oscillated PSHEs, i.e., the spin states are circulated and reversed periodically, are experimentally demonstrated with two PB phase elements fabricated with liquid crystal. The displacements and periods of these oscillations can be controlled by changing the transverse vector of the input Bessel beam. The proposed method offers a new degree of freedom to manipulate the spin-dependent separation, and provides technical supports for the application in spin photonics.
In vivo correlation of serotonin transporter and 1B receptor availability in the human brain: a PET study
Authors: Svensson Jonas E. , Tiger Mikael , Plavén-Sigray Pontus , Halldin Christer , Schain Martin , Lundberg Johan 
Published: July 2022

AbstractSynaptic serotonin levels in the brain are regulated by active transport into the bouton by the serotonin transporter, and by autoreceptors, such as the inhibitory serotonin (5-HT) 1B receptor which, when activated, decreases serotonin release. Animal studies have shown a regulatory link between the two proteins. Evidence of such coupling could translate to an untapped therapeutic potential in augmenting the effect of selective serotonin reuptake inhibitors through pharmacological modulation of 5-HT1B receptors. Here we will for the first time in vivo examine the relationship between 5-HT1B receptors and serotonin transporters in the living human brain. Seventeen healthy individuals were examined with PET twice, using the radioligands [11C]AZ10419369 and [11C]MADAM for quantification of the 5-HT1B receptor and the 5-HT transporter, respectively. The binding potential was calculated for a set of brain regions, and the correlations between the binding estimates of the two radioligands were studied. [11C]AZ10419369 and [11C]MADAM binding was positively correlated in all examined brain regions. In most cortical regions the correlation was strong, e.g., frontal cortex, r(15) = 0.64, p = 0.01 and parietal cortex, r(15) = 0.8, p = 0.0002 while in most subcortical regions, negligible correlations was observed. Though the correlation estimates in cortex should be interpreted with caution due to poor signal to noise ratio of [11C]MADAM binding in these regions, it suggests a link between two key proteins involved in the regulation of synaptic serotonin levels. Our results indicate a need for further studies to address the functional importance of 5-HT1B receptors in treatment with drugs that inhibit serotonin reuptake.
No replication of previously reported association with genetic variants in the T cell receptor alpha (TRA) locus for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
Authors: Ueland Marthe , Hajdarevic Riad , Mella Olav , Strand Elin B. , Sosa Daisy D. , Saugstad Ola D. , Fluge Øystein , Lie Benedicte A. , Viken Marte K. 
Published: July 2022

AbstractMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease with a variety of symptoms such as post-exertional malaise, fatigue, and pain, but where aetiology and pathogenesis are unknown. An increasing number of studies have implicated the involvement of the immune system in ME/CFS. Furthermore, a hereditary component is suggested by the reported increased risk for disease in relatives, and genetic association studies are being performed to identify potential risk variants. We recently reported an association with the immunologically important human leucocyte antigen (HLA) genes HLA-C and HLA-DQB1 in ME/CFS. Furthermore, a genome-wide genetic association study in 42 ME/CFS patients reported significant association signals with two variants in the T cell receptor alpha (TRA) locus (P value <5 × 10−8). As the T cell receptors interact with the HLA molecules, we aimed to replicate the previously reported findings in the TRA locus using a large Norwegian ME/CFS cohort (409 cases and 810 controls) and data from the UK biobank (2105 cases and 4786 controls). We investigated numerous SNPs in the TRA locus, including the two previously ME/CFS-associated variants, rs11157573 and rs17255510. No associations were observed in the Norwegian cohort, and there was no significant association with the two previously reported SNPs in any of the cohorts. However, other SNPs showed signs of association (P value <0.05) in the UK Biobank cohort and meta-analyses of Norwegian and UK biobank cohorts, but none survived correction for multiple testing. Hence, our research did not identify any reliable associations with variants in the TRA locus.
Broader-species receptor binding and structural bases of Omicron SARS-CoV-2 to both mouse and palm-civet ACE2s
Authors: Li Linjie , Han Pu , Huang Baihan , Xie Yufeng , Li Weiwei , Zhang Di , Han Pengcheng , Xu Zepeng , Bai Bin , Zhou Jingya , Kang Xinrui , Li Xiaomei , Zheng Anqi , Zhang Rong , Qiao Shitong , Zhao Xin , Qi Jianxun , Wang Qihui , Liu Kefang , Gao George Fu 
Published: July 2022

AbstractThe Omicron variant of SARS-CoV-2 carries multiple unusual mutations, particularly in the receptor-binding domain (RBD) of the spike (S) protein. Moreover, host-adapting mutations, such as residues 493, 498, and 501, were also observed in the Omicron RBD, which indicates that it is necessary to evaluate the interspecies transmission risk of the Omicron variant. Herein, we evaluated the interspecies recognition of the Omicron BA.1 and Delta RBDs by 27 ACE2 orthologs, including humans. We found that Omicron BA.1 expanded its receptor binding spectra to palm-civet, rodents, more bats (least horseshoe bat and greater horseshoe bat) and lesser hedgehog tenrec. Additionally, we determined the cryo-electron microscopy (cryo-EM) structure of the Omicron BA.1 S protein complexed with mouse ACE2 (mACE2) and the crystal structure of Omicron RBD complexed with palm-civet ACE2 (cvACE2). Several key residues for the host range have been identified. These results suggest that surveillance should be enhanced on the Omicron variant for its broader-species receptor binding to prevent spillover and expansion of reservoir hosts for a prolonged pandemic.
A novel lineage of osteoprogenitor cells with dual epithelial and mesenchymal properties govern maxillofacial bone homeostasis and regeneration after MSFL
Authors: Weng Yuteng , Wang Haicheng , Wu Di , Xu Shuyu , Chen Xiaofan , Huang Jie , Feng Yanhuizhi , Li Lin , Wang Zuolin 
Published: July 2022

AbstractBone regeneration originates from proliferation and differentiation of osteoprogenitors via either endochondral or intramembranous ossification; and the regeneration capacities decline with age and estrogen loss. Maxillary sinus floor lifting (MSFL) is a commonly used surgical procedure for guiding bone regeneration in maxilla. Radiographic analysis of 1210 clinical cases of maxilla bone regeneration after MSFL revealed that the intrasinus osteogenic efficacy was independent of age and gender, however; and this might be related to the Schneiderian membrane that lines the sinus cavity. In view of the particularity of this biological process, our present study aimed to elucidate the underlying mechanism of MSFL-induced bone regeneration. We first established a murine model to simulate the clinical MSFL. By single-cell RNA-sequencing and flow cytometry-based bulk RNA-sequencing, we identified a novel Krt14+Ctsk+ subset of cells that display both epithelial and mesenchymal properties and the transcriptomic feature of osteoprogenitors. Dual recombinases-mediated lineage tracing and loss-of-function analyses showed that these Krt14+Ctsk+ progenitors contribute to both MSFL-induced osteogenesis and physiological bone homeostasis by differentiating into Krt14–Ctsk+ descendants which show robust osteogenic capacity. In addition, we detected a similar population of Krt14+Ctsk+ cells in human samples of Schneiderian membrane, which show a highly similar osteogenic potential and transcriptomic feature to the corresponding cells in mice. The identification of this Krt14+Ctsk+ population, featured by osteoprogenitor characteristics and dual epithelial–mesenchymal properties, provides new insight into the understanding of bone regeneration and may open more possibilities for clinical applications.
Gait analysis dataset of healthy volunteers and patients before and 6 months after total hip arthroplasty
Authors: Bertaux Aurélie , Gueugnon Mathieu , Moissenet Florent , Orliac Baptiste , Martz Pierre , Maillefert Jean-Francis , Ornetti Paul , Laroche Davy 
Published: July 2022

AbstractClinical gait analysis is a promising approach for quantifying gait deviations and assessing the impairments altering gait in patients with osteoarthritis. There is a lack of consensus on the identification of kinematic outcomes that could be used for the diagnosis and follow up in patients. The proposed dataset has been established on 80 asymptomatic participants and 106 patients with unilateral hip osteoarthritis before and 6 months after arthroplasty. All volunteers walked along a 6 meters straight line at their self-selected speed. Three dimensional trajectories of 35 reflective markers were simultaneously recorded and Plugin Gait Bones, angles, Center of Mass trajectories and ground reaction forces were computed. Gait video recordings, when available, anthropometric and demographic descriptions are also available. A minimum of 10 trials have been made available in the weka file format and C3D file to enhance the use of machine learning algorithms. We aim to share this dataset to facilitate the identification of new movement-related kinematic outcomes for improving the diagnosis and follow up in patients with hip OA.
An atlas of endogenous DNA double-strand breaks arising during human neural cell fate determination
Authors: Ballarino Roberto , Bouwman Britta A. M. , Agostini Federico , Harbers Luuk , Diekmann Constantin , Wernersson Erik , Bienko Magda , Crosetto Nicola 
Published: July 2022

AbstractEndogenous DNA double-strand breaks (DSBs) occurring in neural cells have been implicated in the pathogenesis of neurodevelopmental disorders (NDDs). Currently, a genomic map of endogenous DSBs arising during human neurogenesis is missing. Here, we applied in-suspension Breaks LabelingIn Situand Sequencing (sBLISS), RNA-Seq, and Hi-C to chart the genomic landscape of DSBs and relate it to gene expression and genome architecture in 2D cultures of human neuroepithelial stem cells (NES), neural progenitor cells (NPC), and post-mitotic neural cells (NEU). Endogenous DSBs were enriched at the promoter and along the gene body of transcriptionally active genes, at the borders of topologically associating domains (TADs), and around chromatin loop anchors. NDD risk genes harbored significantly more DSBs in comparison to other protein-coding genes, especially in NEU cells. We provide sBLISS, RNA-Seq, and Hi-C datasets for each differentiation stage, and all the scripts needed to reproduce our analyses. Our datasets and tools represent a unique resource that can be harnessed to investigate the role of genome fragility in the pathogenesis of NDDs.
Effects of yoga on cardiometabolic risks and fetomaternal outcomes are associated with serum nitric oxide in gestational hypertension: a randomized control trial
Authors: Karthiga Kuzhanthaivelu , Pal Gopal Krushna , Dasari Papa , Nanda Nivedita , Velkumary Subramanian , Chinnakali Palanivel , Renugasundari Manoharan , Harichandrakumar K. T. 
Published: July 2022

AbstractGestational hypertension (GH) is associated with adverse cardiometabolic and pregnancy outcomes. Though yoga is known to be beneficial in pregnancy, the effects of yoga rendered for twenty weeks starting from 16th week of gestation in pregnant women having risk of GH on the incidence of hypertension, cardiometabolic risks and fetomaternal outcomes have not been studied. A randomized control trial was conducted on 234 pregnant women having risk of GH receiving standard antenatal care (Control group, n = 113), and receiving standard care + yoga (Study group, n = 121). Interventions were given for twenty weeks starting at 16th week of gestation. Baroreflex sensitivity (BRS), heart rate variability (HRV), insulin resistance, lipid-risk factors, and markers of inflammation, oxidative stress and vascular endothelial dysfunction (VED) were assessed before and after intervention. Incidence of new-onset hypertension, level of cardiometabolic risks at 36th week, and fetomaternal-neonatal outcomes in the perinatal period, were noted. The link of hypertension, pregnancy outcomes and cardiometabolic risks with nitric oxide (NO), the marker of VED was assessed by analysis of covariance, Pearson’s correlations, and multilinear and logistic regressions. In study group, 6.61% women developed hypertension compared to 38.1% in the control group following 20-week intervention and there was significant decrease in risk of developing GH (RR, 2.65; CI 1.42–4.95). There was less-painful delivery, decreased duration of labor, increased neonatal birthweight and Apgar score in study group. Increase in total power of HRV (β = 0.187, p = 0.024), BRS (β = 0.305, p < 0.001), and decrease in interleukin-6 (β =  − 0.194, p = 0.022) had significant association with increased NO. Twenty weeks of practice of yoga during pregnancy decreases the incidence of hypertension, improves fetomaternal outcomes, and reduces cardiometabolic risks in pregnant women having risk of GH. Decreased blood pressure, increased HRV, BRS and birth weight and decreased inflammation were associated with improved endothelial function.
Trial registration: Clinical Trials Registry of India (CTRI), registration number: CTRI/2017/11/010608, on 23.11.2017.
Cartilage thickness and bone shape variations as a function of sex, height, body mass, and age in young adult knees
Authors: Schneider Marco Tien-Yueh , Rooks Nynke , Besier Thor 
Published: July 2022

AbstractThe functional relationship between bone and cartilage is modulated by mechanical factors. Scarce data exist on the relationship between bone shape and the spatial distribution of cartilage thickness. The aim of the study was to characterise the coupled variation in knee bone morphology and cartilage thickness distributions in knees with healthy cartilage and investigate this relationship as a function of sex, height, body mass, and age. MR images of 51 knees from young adults (28.4 ± 4.1 years) were obtained from a previous study and used to train a statistical shape model of the femur, tibia, and patella and their cartilages. Five multiple linear regression models were fitted to characterise morphology as a function of sex, height, body mass, and age. A logistic regression classifier was fitted to characterise morphological differences between males and females, and tenfold cross-validation was performed to evaluate the models’ performance. Our results showed that cartilage thickness and its distribution were coupled to bone morphology. The first five shape modes captured over 90% of the variance and described coupled changes to the bone and spatial distribution of cartilage thickness. Mode 1 (size) was correlated to sex (p < 0.001) and height (p < 0.0001). Mode 2 (aspect ratio) was also correlated to sex (p = 0.006) and height (p = 0.017). Mode 4 (condylar depth) was correlated to sex only (p = 0.024). A logistic regression model trained on modes 1, 2, and 4 could classify sex with an accuracy of 92.2% (95% CI [81.1%, 97.8%]). No other modes were influenced by sex, height, body mass, or age. This study demonstrated the coupled relationship between bone and cartilage, showing that cartilage is thicker with increased bone size, diaphysis size, and decreased femoral skew. Our results show that sex and height influence bone shape and the spatial distribution of cartilage thickness in a healthy young adult population, but body mass and age do not.
Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion
Authors: Giroux Nicholas S. , Ding Shengli , McClain Micah T. , Burke Thomas W. , Petzold Elizabeth , Chung Hong A. , Rivera Grecia O. , Wang Ergang , Xi Rui , Bose Shree , Rotstein Tomer , Nicholson Bradly P. , Chen Tianyi , Henao Ricardo , Sempowski Gregory D. , Denny Thomas N. , De Ussel Maria Iglesias , Satterwhite Lisa L. , Ko Emily R. , Ginsburg Geoffrey S. , Kraft Bryan D. , Tsalik Ephraim L. , Shen Xiling , Woods Christopher W. 
Published: July 2022

AbstractSARS-CoV-2 infection triggers profound and variable immune responses in human hosts. Chromatin remodeling has been observed in individuals severely ill or convalescing with COVID-19, but chromatin remodeling early in disease prior to anti-spike protein IgG seroconversion has not been defined. We performed the Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) and RNA-seq on peripheral blood mononuclear cells (PBMCs) from outpatients with mild or moderate symptom severity at different stages of clinical illness. Early in the disease course prior to IgG seroconversion, modifications in chromatin accessibility associated with mild or moderate symptoms were already robust and included severity-associated changes in accessibility of genes in interleukin signaling, regulation of cell differentiation and cell morphology. Furthermore, single-cell analyses revealed evolution of the chromatin accessibility landscape and transcription factor motif accessibility for individual PBMC cell types over time. The most extensive remodeling occurred in CD14+ monocytes, where sub-populations with distinct chromatin accessibility profiles were observed prior to seroconversion. Mild symptom severity was marked by upregulation of classical antiviral pathways, including those regulating IRF1 and IRF7, whereas in moderate disease, these classical antiviral signals diminished, suggesting dysregulated and less effective responses. Together, these observations offer novel insight into the epigenome of early mild SARS-CoV-2 infection and suggest that detection of chromatin remodeling in early disease may offer promise for a new class of diagnostic tools for COVID-19.