bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value-Based Insurance Design: Clinically Nuanced Consumer Cost Sharing to Increase the Use of High-Value Medications
Authors: Smith Nicholas K. , Fendrick A. Mark 
Published: July 2022

Abstract
Consumer cost sharing is widely employed by payers in the United States in an effort to control spending. Most cost-sharing strategies set patient contributions on the basis of costs incurred by payers and often do not consider medical necessity as a coverage criterion. Available evidence suggests that increases in cost sharing worsen health disparities and adversely affect patient-centered outcomes, particularly among economically vulnerable individuals, people of color, and those with chronic conditions. A key question has been how to better engage consumers while balancing appropriate access to essential services with increasing fiscal pressures. Value-based insurance design (VBID) is a promising approach designed to improve desired clinical and financial outcomes, in which out-of-pocket costs are based on the potential for clinical benefit, taking into consideration the patient's clinical condition. For more than two decades, broad multistakeholder support and multiple federal policy initiatives have led to the implementation of VBID programs that enhance access to vital preventive and chronic disease medications for millions of Americans. A robust evidence base shows that when financial barriers to essential medications are reduced, increased adherence results, leading to improved patient-centered outcomes, reduced health care disparities, and in some (but not most) instances, lower total medical expenditures.
Synthesis of Optically Active π-Stacked Molecules: Effect of π-Stacking Position on the Chiroptical Properties
Authors: Sawada Risa , Gon Masayuki , Chujo Yoshiki , Inoue Ryo , Morisaki Yasuhiro 
Published: July 2022

Abstract
Optically active V-shaped and X-shaped molecules consisting of stacked five-ringed para-phenylene-ethynylenes (PPEs) were prepared using planar chiral [2.2]paracyclophanes as chiral building blocks. Despite having the same absolute configurations, the V- and X-shaped molecules exhibited opposite circular dichroism (CD) and circularly polarized luminescence (CPL) signals. For example, the (Sp)-isomer of the V-shaped molecule and (Sp)-isomers of the X-shaped molecules exhibited negative and positive CPL emissions, respectively. Simulations using time-dependent density-functional theory calculations indicated that the lowest unoccupied molecular orbital (LUMO) of the V-shaped molecule in the S1 state was localized in one of the stacking PPEs, whereas the LUMOs of the two X-shaped molecules in the S1 state were delocalized in both PPEs via the [2.2]paracyclophane moieties. The theoretical results were reproduced and explained the CD and CPL behaviors well.
The Role of Muscle Glycogen Content and Localization in High-Intensity Exercise Performance: A Placebo-Controlled Trial
Authors: VIGH-LARSEN JEPPE F. , ØRTENBLAD NIELS , NIELSEN JOACHIM , EMIL ANDERSEN OLE , OVERGAARD KRISTIAN , MOHR MAGNI 
Published: July 2022

ABSTRACT

Purpose
We investigated the coupling between muscle glycogen content and localization and high-intensity exercise performance using a randomized, placebo-controlled, parallel-group design with emphasis on single-fiber subcellular glycogen concentrations and sarcoplasmic reticulum Ca2+ kinetics.

Methods
Eighteen well-trained participants performed high-intensity intermittent glycogen-depleting exercise, followed by randomization to a high- (CHO; ~1 g CHO·kg−1·h−1; n = 9) or low-carbohydrate placebo diet (PLA, <0.1 g CHO·kg−1·h−1; n = 9) for a 5-h recovery period. At baseline, after exercise, and after the carbohydrate manipulation assessments of repeated sprint ability (5 × 6-s maximal cycling sprints with 24 s of rest), neuromuscular function and ratings of perceived exertion during standardized high-intensity cycling (~90% W
max) were performed, while muscle and blood samples were collected.

Results
The exercise and carbohydrate manipulations led to distinct muscle glycogen concentrations in CHO and PLA at the whole-muscle (291 ± 78 vs 175 ± 100 mmol·kg−1 dry weight (dw), P = 0.020) and subcellular level in each of three local regions (P = 0.001–0.046). This was coupled with near-depleted glycogen concentrations in single fibers of both main fiber types in PLA, especially in the intramyofibrillar region (within the myofibrils). Furthermore, increased ratings of perceived exertion and impaired repeated sprint ability (~8% loss, P < 0.001) were present in PLA, with the latter correlating moderately to very strongly (r = 0.47–0.71, P = 0.001–0.049) with whole-muscle glycogen and subcellular glycogen fractions. Finally, sarcoplasmic reticulum Ca2+ uptake, but not release, was superior in CHO, whereas neuromuscular function, including prolonged low-frequency force depression, was unaffected by dietary manipulation.

Conclusions
Together, these results support an important role of muscle glycogen availability for high-intensity exercise performance, which may be mediated by reductions in single-fiber levels, particularly in distinct subcellular regions, despite only moderately lowered whole-muscle glycogen concentrations.
Professional qualifications of medical affairs pharmaceutical physicians and other internal stakeholders in the pharmaceutical industry
Authors: Jandhyala Ravi 
Published: July 2022

Background: Medical affairs pharmaceutical physicians (MAPPs) have unique value to pharmaceutical companies due to their accountability for activities that benefit regulators, payors, prescribers and patients. This study assessed whether MAPPs’ specialist training and education in pharmaceutical medicine could account for this level of value by determining whether there was significant variation in education and training between MAPPs and other internal stakeholders of pharmaceutical companies. Methods: A systematic search of LinkedIn profiles from the 10 pharmaceutical companies by revenue was conducted between June and October 2021. Job title and type and year of undergraduate and postgraduate qualifications were extracted. A one-sided Mann-Whitney test assessed for differences in the total number of qualifications between MAPPs and other internal stakeholders involved in medical affairs using MAPPs as the reference group. Other internal stakeholders included medical affairs pharmacists (MAPharm), other medical affairs professionals (MAOth), and market access (MAcc), commercial (COmm) and sales professionals. Sub-group analysis determined differences in undergraduate and postgraduate education. Results: In total, 524 profiles were included. Compared to all other internal stakeholders, MAPPs had a significantly higher number of undergraduate (p < 0.001) and postgraduate (MAPharm, p = 0.003; MAOth, p = 0.004; MAcc, COmm and Sales, p < 0.001) qualifications. Additionally, MAPPs had a significantly longer time to industry than other internal stakeholders apart from MAPharm. Of those with clinical qualifications, MAPPs were almost twice as likely to have business qualifications. Conclusions: Of all internal stakeholders, MAPPs had the highest number of qualifications and the best match between expertise and the contextual demands of decision-makers in the pharmaceutical industry. Pharmaceutical companies in the UK can use these findings to clarify role boundaries and decision-making power based on the nature and level of expertise of each internal stakeholder.
The Dial-a-Ride Problem with School Bell Time Adjustment
Authors: Vercraene Samuel , Lehuédé Fabien , Monteiro Thibaud , Péton Olivier 
Published: July 2022

In this paper, we study a paratransit application in which children are transported every day from their homes to their special schools or medical-social establishments. To optimize this transportation system, the establishments collaborate to propose a joint transportation plan. We propose a new algorithm to jointly build vehicle routes that visit several establishments and simultaneously set the establishments’ opening hours. This algorithm combines a large neighborhood search, the resolution of a route-based model, and the progressive shrinkage of the planning window. It is applied to a real case from the area of Lyon in France, including 34 schools and 575 heterogeneous users served by a heterogeneous fleet of reconfigurable vehicles. On average, we show that in addition to the 10% of saving that can be expected by sharing vehicle routes between schools, 7% of additional savings can be achieved by school bell adjustment. This cost saving also decreases average user ride times and the number of vehicles required, creating longer routes that are more attractive for driver services. Funding: This work was supported by the European Union through the European Regional Development Fund [Grant RA0012500] and by the French Région Auvergne-Rhône-Alpes through the NOMAd project. Supplemental Material: The online appendices are available at https://doi.org/10.1287/trsc.2022.1160 .
Formal and Informal Supports for Women With Intellectual and Developmental Disabilities During Pregnancy
Authors: Rosenthal Eliana , Parish Susan L. , Ransom Cristina , Smith Lauren D. , Mitra Monika 
Published: July 2022

Abstract
This article explores the role of formal and informal supports for women with intellectual and developmental disabilities (IDD) throughout their pregnancy, childbirth, and postpartum experiences. Data from qualitative interviews with women with IDD (n = 16) were analyzed. Results showed that formal supports aided in planning, transportation, advocacy, and providing emotional support throughout pregnancy. Informal supports helped with errands, comfort, and emotional encouragement. The community surrounding these women facilitated communication with providers, self-empowerment regarding health choices, and increased preparedness for parenthood. Findings indicate the importance of encouraging and sustaining both formal and informal supports during pregnancy, childbirth, and postpartum to improve pregnancy and parenting experiences for women with IDD.
Prevalence of Secondary Traumatic Stress Among Direct Support Professionals in Intellectual and Developmental Disabilities Field
Authors: Boamah Daniel A. , Barbee Anita P. 
Published: July 2022

Abstract
Direct support professionals (DSPs) are deemed by existing literature as vital support to persons with intellectual or developmental disabilities (IDD). They may be exposed to the traumatic experiences of people with IDD with potential psychological implications. Secondary traumatic stress (STS) has been studied among related professionals across human services, but little is known among DSPs. The current study examines the prevalence of STS in a sample of DSPs. The results suggested that DSPs are exposed to traumatic experiences, and exposure to a greater number of traumatized clients is significantly correlated with symptoms of STS. At least 12.4% of DSPs in this sample met the diagnostic criteria for experiencing post-traumatic stress disorder (PTSD) symptoms. Also, results suggest STS differences in DSPs based on demographics.
Seeking Out Social Learning: Online Self-Education in Parents of Children With Intellectual and Developmental Disabilities
Authors: Karns Christina M. , Todis Bonnie , Glenn Elizabeth , Glang Ann , Wade Shari L. , Riddle Ilka , McIntyre Laura Lee 
Published: July 2022

Abstract
Supportive, informed parenting is critical to improve outcomes of children who experience intellectual and developmental disabilities (IDD). Parents want to learn about their child's condition, needs, and strategies to improve family life. The internet is a valuable resource, but how parents evaluate and apply information is unknown. We conducted focus groups to understand how parents use internet resources to learn about their children with IDD. Parents described using the internet to access information from trusted sources, find examples to apply their knowledge, and seek social support. Social learning theory, which posits that cognitive, behavioral, and social processes influence each other to support real-world learning, could provide a theoretical framework for unifying these findings and for designing efficacious online interventions.
Reverse Stein–Weiss, Hardy–Littlewood–Sobolev, Hardy, Sobolev and Caffarelli–Kohn–Nirenberg inequalities on homogeneous groups
Authors: Kassymov Aidyn , Ruzhansky Michael , Suragan Durvudkhan 
Published: July 2022

Abstract
In this note, we prove the reverse Stein–Weiss inequality on general homogeneous Lie groups. The results obtained extend previously known inequalities. Special properties of homogeneous norms and the reverse integral Hardy inequality play key roles in our proofs. Also, we prove reverse Hardy, Hardy–Littlewood–Sobolev,

L
p

{L^{p}}

-Sobolev and

L
p

{L^{p}}

-Caffarelli–Kohn–Nirenberg inequalities on homogeneous Lie groups.
Design X Bioinformatics: a community-driven initiative to connect bioinformatics and design
Authors: Sommer Björn , Inoue Daisuke , Baaden Marc 
Published: July 2022

Abstract
Bioinformatics applies computer science approaches to the analysis of biological data. It is widely known for its genomics-based analysis approaches that have supported, for example, the 1000 Genomes Project. In addition, bioinformatics relates to many other areas, such as analysis of microscopic images (e.g., organelle localization), molecular modelling (e.g., proteins, biological membranes), and visualization of biological networks (e.g., protein–protein interaction networks, metabolism). Design is a highly interdisciplinary field that incorporates aspects such as aesthetic, economic, functional, philosophical, and/or socio-political considerations into the creative process and is usually determined by context. While visualization plays a critical role in bioinformatics, as reflected in a number of conferences and workshops in the field, design in bioinformatics-related research contexts in particular is not as well studied. With this special issue in conjunction with an international workshop, we aim to bring together bioinformaticians from different fields with designers, design researchers, and medical and scientific illustrators to discuss future challenges in the context of bioinformatics and design.
Tarihi Çarşılardaki Tüketim Ritüelleri: Eski Ve Yeni İşleyişin Sentezi
Authors: YAVUZ Ayşe , TARHAN Ahmet 
Published: July 2022

İnsanın yaradılışı ile başlayan ve insanlığın gelişimi ile değişime uğrayan tüketim, ilkel temelde sadece fizyolojik ihtiyaçların giderilmesinden ibaretken zamanla psikolojik, sosyal ve duyusal özellikler kazanmıştır. Kişinin doğup büyüdüğü aile ve toplumun kültürel özellikleri, dini ve mitolojik inançlar, kişisel tercih ve karakter yapısı tüketim eyleminin zamanla karmaşık ve çok yönlü bir yapıya dönüşmesine zemin hazırlamıştır. Tüketim toplumunun ortaya çıkışı, kitle iletişim araçlarının gelişimi, geleneksel kültürden popüler kültüre doğru olan geçiş, toplumların tüketim alışkanlıklarının değişmesine neden olmuştur.
Bireylerin tüketim alışkanlıklarında meydana gelen bu değişimin tarihi çarşıları nasıl etkilediğini tespit etmek, eski ve yeni tüketim ritüelleri arasındaki temel farkları incelemek için yürütülen çalışma kapsamında günümüzde hala işlerliğini koruyan tarihi çarşılara güzel bir örnek olan Konya Bedesten Çarşısı’ndaki esnaflar ile görüşme yapılmıştır. Çarşıda eskiden yürütülen birtakım ritüellerin neler olduğu, hala devam edip etmediği, müşterilerinin eski ve şu andaki tüketim alışkanlıkları arasındaki değişimler ve bu olguların ticari hayata etkisi üzerine bilgiler toplanmıştır. Görüşmeler sonucu Konya Bedesten Çarşısı’nın, oldukça köklü bir kültüre sahip olduğu, ticari fonksiyonunun yanında sosyal ve kültürel değerlerin bir aktarıcısı haline geldiği tespit edilmiştir. Burada faaliyet gösteren esnafların, bir yandan gelenekleri yaşatma çabasındayken diğer yandan yeniliklere ayak uydurmaya çalışması, geleneksel çarşı kültürünü bir süre daha kuşaktan kuşağa aktarma gayretinde olduklarını göstermektedir.
Digital Footprint Management In Dıigital Visual Culture
Authors: MAYDA Mustafa 
Published: July 2022

In the development of digital visual culture, data emerges as the most important tool. Especially when the role of digital visual data in the construction of the virtual world is considered, it is seen that it is at the center of all digital processes. The actions and contents of the individual in the virtual environment develop depending on the management of the data.
When digital content processes are evaluated in the digital world, it is seen that data density increases at an exponential rate. In this framework, new scientific initiatives should be revealed in order for these contents to be defined as digital footprints and managed by the individual. It is important to define new concepts and processes for the management of data in digital communication processes, especially by considering the design area of the digital footprint and the contact points. In this context, new approaches have been tried to be put forward by considering the subject.
In this study, the subject has been dealt with descriptively in order to contribute to the literature, and it has been tried to reveal the expansions for the management of the digital footprint created through the design discipline in the formation of digital visual culture. In the research, it has also been tried to explain how the digital footprint affects the digital communication processes with examples.
Innovative technology of total parietal peritonectomy for peritoneal carcinomatosis
Authors: Prosvetov Vadim A. , Surov Dmitry A. , Gaivoronsky Ivan V. , Nguyen Van Thu 
Published: July 2022

BACKGROUND: Peritonectomy is an integral part of cytoreductive surgery, accompanied by a fairly high incidence of postoperative complications and mortality. In this regard, the improvement and development of easy-to-perform, low-traumatic and safe methods of peritonectomy are topical in oncology.
AIM: Based on experimental studies to develop a technology of pneumodissection of the peritoneum using carbon dioxide insufflation and evaluate its effectiveness.
MATERIALS AND METHODS: The study was conducted on 10 non-embalmed corpses of deceased people whose cause of death is not related to tumors of the abdominal cavity and pelvic organs. The Karl STORZ Thermoflator 26432020-1 Insufflator (FSZ registration certificate 2011/09444, dated 12/21/2017), carbon dioxide cylinders with a volume of 20 liters, silicone lines 1.5 meters long, 1 cm in diameter; Seldinger puncture needle 18 G; flexible polypropylene bougie 16 G were used.
RESULTS: The conducted experimental study made it possible to develop and test a method of total parietal peritonectomy based on the technology of peritoneal pneumodissection using carbon dioxide insufflation. The analysis of the obtained results made it possible to define the concept of a new technology as a method of tissue separation based on the insufflation of carbon dioxide into the connective tissue layers of the retroperitoneal space for the purpose of safe dissection of anatomical structures.
CONCLUSIONS: Peritoneal pneumodissection using gas insufflation is a new and promising technology with a number of obvious advantages. First of all, they include ease of execution, low injury, high safety and, probably, ablasticity, which can potentially create conditions for the prevention of unintentional dissemination of tumor cells in the abdominal cavity. The data obtained as a result of the experimental study allow us to conclude that pneumodissection of the peritoneum using carbon dioxide insufflation is an effective method of performing total parietal peritonectomy and can be used in performing cytoreductive surgical interventions in patients with peritoneal carcinomatosis.
Asesmen Produktivitas Ternak dan Kesesuaian Potensi Tanaman Pertanian Sebagai Hijauan Pakan: Sebuah Potret Kawasan Agro-Ekologi Dataran Rendah Selatan Merauke, Papua
Authors: Yohanes Hieronymus , Muyan Yafed , Rumetor Sientje , Palulungan Jhon Arnold , Baaka Alnita , Nurhayati Dwi , Arim Maria , Saragih Desni , Bauw Aisyah , Syufi Yafed , Novi Maya , Syamsu Jasmal , Iyai Deny Anjelus 
Published: July 2022

The study aimed to descriptively capture livestock production and food waste and the suitability of border farms in the lowland Merauke region. Data were analyzed on livestock population structure (individual/ST), food crop waste production (dry weight, DW), capacity, and location quotient (LQ), and SWOT. Food crop waste production is 350 thousand tons of DW and so far only provided for ruminant cattle about 11%. Food crop straw waste is still dominated by rice straw (97%), followed by corn waste (2%), sweet potatoes, and peanuts. The capacity to increase the cattle population is close to 315 thousand ST. The LQ value of both livestock and food crops in Merauke is still in the range of 0 -<1 and is still a prospective sector to be optimized. The results of SWOT analysis conclude that the S-O strategy is the intensification and expansion of livestock commodities. Keywords: livestock population structure, location quotient, KPPTR, crop residues, Merauke
A Critical Analysis of the Enactment of the Allow States and Victims to Fight Online Sex Trafficking Act of 2018
Authors: DeLacey Hannah 
Published: July 2022

This paper presents a critical analysis of the Allow States and Victims to Fight Online Sex Trafficking Act of 2018 (FOSTA), and the debate in the United States Congress that led to its enactment. Although the stated intention of this law was to protect victims of trafficking and for websites to be held accountable for their role in facilitating trafficking, FOSTA was controversial. It was predicted that FOSTA would be ineffective at achieving these goals and that sex workers would be disproportionately affected.

Two methodological approaches were used in order to understand why and how FOSTA was enacted - phronetic analysis (Flyvbjerg, 2001) and Bacchi’s (2009) the what’s the problem represented to be approach. These approaches guided the process of analysis of congressional debates related to FOSTA, and the collection and analysis of additional data.
Based on this analysis, this paper argues that lawmakers and other stakeholders created and disseminated a powerful narrative about sex trafficking in order to convince lawmakers to vote in favor of FOSTA. Those who spoke out against this narrative were ignored or silenced, and those who were expected to be most impacted by FOSTA (e.g. sex workers) were excluded from the discussion. This article gives insight into the lawmaking process and how it can be shaped by various actors and ideologies, and how sex workers are impacted by legislation aimed at curtailing sex trafficking.
Parents Experiences Using Alternative Medicine on Children Suffering Cancer in Jakarta
Authors: Hermalinda Hermalinda , Rustina Yeni , Novieastari Enie 
Published: July 2022

Introduction: Alternative medicine are very popular today as a therapy that are believed to treat cancer. A phenomenology study was carried out to identify the experince of parent’s in using alternative medicine for children with cancer.Methods: The method of data collection was indepth interview to eigth parents and data was analyzed by Colaizii’s method. Themes of this research are the impact of illness to children, parent’s effort, description of alternative medicine, the effect of alternative medicine for children, meaning of using alternative medicine and parents expectation.Results: No benefit effect for children and detterence effect in using alternative medicine are current fi ndings in this research. Conclusion: Healthcare professional should concerned about using alternative medicine in children and providing adequate information regarding effectiveness and adverse effects of alternative medicine.