bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelatihan Cara Packing Produk Usaha Mikro Kecil dan Menengah
Authors: Yuniarti Puji , Rini Ratih Setyo , Taruna Helmy Ivan , Rahman Aan 
Published: November 2022

Pelaksanaan pengabdian masyarakat dengan mitra Koperasi Wanita Atsiri Citayam Bogor dilaksanakan secara hybrid yaitu offline dan online. Dikarenakan saat ini pemerintah sudah mulai melonggarkan kegiatan pertemuan masyarakat, kegiatan dapat berlangsung secara tatap muka. Namun demikian kegiatan pelatihan ini tetap dilaksanakan dengan protokol kesehatan yang ketat. Permasalahan utama anggota Koperasi Wanita Atsiri Citayam Bogor antara lain terjadinya peralihan penjualan secara langsung atau konvensional menjadi penjualan secara online, secara khusus membutuhkan bentuk kemasan yang lebih khusus yang aman dalam pengiriman. Dengan demikian koperasi yang memiliki banyak anggota para pelaku UMKM di bidang kuliner ini membutuhkan sentuhan kemasan yang menarik sehingga diminati pasar. Pengabdian masyarakat ini bertujuan untuk membantu para anggota Koperasi Wanita Atsiri tentang cara melakukan pengemasan produk untuk keberlangsungan usahanya. Pelatihan ini merupakan tempat pembelajaran bagi Anggota Koperasi Wanita Atsiri Citayam Bogor agar dapat memberikan wawasan desain dan bentuk kemasan baru yang membuat produk menjadi lebih bernilai, aman, menarik, khususnya untuk kemasan dalam penjualan secara online.
Causes of Growing Child Labor in India
Authors: Singh Savita , Shukla Pratima 
Published: November 2022

Children are the country's new generations, and their proper development is the nation's prime focus. Youngsters all across the globe are involved in a wide range of work-related tasks. These vary from innocuous, even praiseworthy, hobbies to mentally damaging and deeply immoral persons. Forced labor is a difficult and sensitive topic.
Millions of youngsters labour in appalling and unscrupulous situations that are plainly hazardous to their health. India is one of the leading nations in terms of the proportion of the workforce that is 'child abuse.' In recent years, A lot of attention has been paid to child labour from the Government, social scientists, voluntary organizations, etc. The Constitution of India also guarantees protection of the rights of children. Despite social consciousness and many prohibitions, the number of child labour is increasing.
There are also many social factors of child labour such as inadequate family income, large families, poverty, illiteracy etc. Therefore, the issue of child labour needs to be looked into not only by the Legislature, the Executive and the Courts, but also to the social reformers, research and educational institutions of the NGO who look after the development and development of the nation. Child labour cannot end overnight because its roots are very deep. Laws should be strictly implemented to prevent child labour.
Automatic Image Tagging Based on Text Analysis Using Natural Language Processing Techniques
Authors: Maity Alok 
Published: November 2022

I have seen that in any newspaper there are many articles related to different things and the article consists of some text and one or more images which are related to the given text. Some of the images given in the article have caption (which depicts the image) and the other images do not have any caption. Hence if I download the image which has no caption then after download, I will not understand what the image specifically describes.
To address this kind of situation it is necessary to give the image some caption which depicts about the situation of the image and the information about the image. After download the image if I give some relevant tag to the image then it will be helpful for all.
In modern era images are taken and stored digitally. Also, the prices of the image capturing devices are decreasing. Hence people are taking more and more pictures but handling of pictures are necessary at this situation. Additionally, there is a huge uptick in the use of web-based image-sharing programmes or applications. One of the most widely used of these applications is Flickr, which was acquired by Yahoo and now stores over 4 billion images.
Image tagging by hand takes time and is subjective. Nobody has time to tag their images. Additionally, because people differ and think in different ways, comparable images will be tagged in various ways by different people. Differences in language, emotion, vocabulary, education, culture, taste, etc. may be the root of this.
Application of Ion Exchange Chromatography in the Development of Technology to Obtain Inactivated Poliovirus Vaccine
Authors: Piniaeva A. N. , Kovpak A. A. , Ivin Y. Y. , Sandzhieva S. H. , Shishova A. A. , Tсelykh I. O. , Vasilenko V. E. , Kaa K. V. , Mazhed Zh. H. , Khapchaev Yu. Kh. , Siniugina A. A. , Ishmukhametov A. A. 
Published: November 2022

Relevance. The production and quality control of any drugs are strictly regulated. In the case of antiviral vaccines, the requirements for their safety and protective activity are getting tougher every year. Vaccine manufacturers face three tasks: ensuring high immunogenicity, safety and availability of the drug. During the development and production of immunobiological drugs, manufacturers must demonstrate sufficient purification from technological impurities to ensure the purity of the drug. Technological impurities directly depend on the technological process and the expression systems used. The Vero cell line has been widely used in the production of various antiviral vaccines for many decades. Thus, the improvement of technological processes for the purification of vaccine preparations from proteins and DNA of Vero cells is still matter of current interest.Aims. Selection of resins and reagents for ion exchange chromatography to reduce the amount of technological impurities in the inactivated polio vaccine production.Materials and Methods. To obtain viral suspensions, producer cultures were infected with poliovirus type 1 (Sabin strain LSc 2ab), type 2 (Sabin strain P712 Ch 2ab), and type 3 (Sabin strain Leon 12a1b). Multiplicity of infection was 0.02 ± 0.01 TCD50/cell. To evaluate the efficiency of ion-exchange chromatography we determined the degree of purification of fractions from ballast proteins, the degree of purification of fractions from residual cellular DNA, and the degree of extraction of the target antigen using specific formulas.Results and discussion. More than 80 experiments have been performed to purify type 1, type 2, and type 3 poliovirus concentrates using various sorbents. In quality control of purified concentrates of type 1, type 2 and type 3 polioviruses, in addition to analysis for total protein, an analysis was performed for the presence of Vero cell proteins.Conclusion. The use of the proposed modifications of purification of concentrates of Sabin strains of poliovirus types 1, 2 and 3 using ion exchange chromatography allows to obtain inactivated viral products that meet the requirements of WHO and the European Pharmacopoeia both in biochemical parameters (the content of host-cell DNA and the content of ballast proteins, including host-cell proteins) and specific activity (D-antigen content). Furthermore, additional purification of vaccines using ion exchange chromatography allows to reduce the content of residual cellular DNA to almost zero, which makes the inactivated polio vaccine the most attractive for its inclusion in various combined vaccines.
Evaluation of the Effectiveness of Immunization Saint-Petersburg Population against COVID-19
Authors: Dar'ina M. G. , Ljubimova A. V. , Svetlichnaja Yu. S. , Zahvatova A. S. , Jazenok A. V. , Harit S. M. , Aslanov B. I. 
Published: November 2022

Relevance. Vaccination is being replaced by the primary and most effective means of protecting the world's population from a new coronavirus infection.Aim. Evaluation of the effectiveness of COVID-19 immunization in Saint-Petersburg.Materials and methods: We retrospectively studied the epidemiological data on the cumulative incidence of COVID-19 in St. Petersburg among adults vaccinated (1,558,030 people) and unvaccinated (2,863,050 people) for period from December 01, 2020 to November 30, 2021 on 12.01.2021. We analyzed the data presented in the Federal Register of Persons with COVID-19 and the Federal Register of Those Vaccinated against COVID-19.Results. The risk of COVID-19 infection among vaccinated is statistically significantly lower than among unvaccinated RR = 0.11 (95% CI 0.109–0.110; p < 0.001). Infected COVID-19 Vaccinated patients were less likely to need for emergency care/hospitalization RR = 0.30 (95% CI 0.29–0.30; p < 0.001). Also among the vaccinated mortality was lower RR = 0.35 (95% CI 0.33–0.37; p < 0.001).Conclusion: We have established reliable preventive effectiveness of the use of domestic vaccines by reducing morbidity, the frequency of development of forms of the disease requiring inpatient treatment; reducing mortality among vaccinated and, accordingly, reducing the burden on the healthcare system of St. Petersburg.
Evaluation of the Effectiveness of Vaccination of Russian Railways employees
Authors: Kostenko N. A. , Jidkova E. A. , Goriaev A. A. , Shangin I. V. , Khaltourina D. A. , Matveyev Y. N. , Ustyuzhanin V. V. , Gurevich K. G. 
Published: November 2022

Relevance. The effectiveness of vaccination of the working population against COVID-19 in the Russian background has not been studied enough.Aim. To evaluate the effectiveness of vaccination of the working population with Gam-COVID-Vak (Sputnik V) in the Russian Railways as an example.Materials & Methods.The effectiveness of vaccination with Sputnik V among employees of Russian Railways in the period from January 21 to November 31, 2021 was performed with the Cox regression method.Results. The effectiveness of Sputnik V against COVID-19 infection with was 97.8% (95% CI 97.8–97.9%) for two doses, 91.9% (95% CI 91.6–92.2%) for a single dose, and 97.9% (95% CI 97.6–98.1%) for revaccination, all after socio-demographic factors adjusted. The effectiveness of vaccination against COVID-19 with hospitalization was 97.5% for two doses of Sputnik V (95% CI 97.1–97.9%), 86.1% (95% CI 83.7–88.1%) for a single dose, and 98.2% (95% CI 96.3–99.2%) for revaccination. The effectiveness against lethal COVID-19 was 95.2% (95% CI 93.1–96.6%) for two doses of Sputnik V and 94.8% (95% CI 89–97.6%) for one dose. The high efficiency of vaccination could be associated with a fairly young age composition of the employees of the Russian Railways.Conclusions. The study showed the high effectiveness of vaccination with Sputnik V against COVID-19 among the working population.
Monitoring System for Adverse Events Following Immunization in Russia and the World. Modern aspects and problems
Authors: Bakhmutskaya E. V. , Chernyavskaya O. P. , Volkova N. A. 
Published: November 2022

Relevance. During a pandemic, the epidemiological well-being of the population of the whole world depends on the vaccination of each individual person, as cells of the immune layer. Only reliable and open information about adverse events after the use of vaccines, obtained in a timely manner in the process of continuous monitoring, can support the confidence and adherence of the population to vaccination.Aim. To assess the monitoring system for AEFI (Adverse Events Following Immunization) in the Russian Federation and other countries.Materials and methods. A descriptive epidemiological study was conducted with a review of regulatory and methodological documents, forms of federal statistical observation, information from the AIS «DRAID» (Analytical Information System «Department of registration and accounting of infectious diseases» program in Moscow, acts of investigation of post-vaccination complications, which were carried out by specialists from the branches of the Center for Hygiene and Epidemiology in Moscow, sources: eLIBRARU.ru, cyberleninka.ru, information from WHO’s websites, Internet resources for monitoring AEFIs in different countries and websites of manufacturers of COVID-19 vaccines, instructions for vaccines.Conclusion. Thus, it is almost impossible for an epidemiologist working in one of the departments that participates in the monitoring of AEFIs to conduct a full-fledged prospective and retrospective epidemiological analysis and draw unambiguous conclusions about the AEFIs based only on data from open sources and forms of state statistical observation. There is a need for interaction and exchange of information between the subjects of monitoring.
Analysis of the Features of the Genomic Organization of Plague Microbe Strains Suitable for the Creation of a New Attenuated Vaccine
Authors: Grigorievykh A. V. , Bochalgin N. O. , Vityazeva S. A. , Pescherova R. I. , Mukhturgin G. B. , Dubrovina V. I. , Mironova L. V. , Balakhonov S. V. 
Published: November 2022

Relevance. To date, the specific prevention of plague remains the most effective measure to prevent to prevent the deterioration of the epidemiological situation for this especially dangerous infection in the territory of the Russian Federation. The development of new vaccine preparations created on the basis of avirulent strains of Yersinia pestis with specific genetic defects, can play a crucial importance in the issues of plague immunoprophylaxis.Aim. Determination and comparative analysis of the genomic organization of avirulent strains Y. pestis I-1, Y. pestis I-3536 and vaccine strain Y. pestis EV line NIIEG.Materials and methods. The features of the genetic structure of three Y. pestis strains were studied using plasmid screening and whole genome sequencing.Results and discussion. It was found that the Y. pestis I-1 and Y. pestis I-3536 strains, like Y. pestis EV, lack the chromosomal pgm region. Analysis the genome sequence of Y. pestis I-1 showed that this strain is devoid of the plasmid pMT1, while its individual genes were found in the chromosome structure and the unique 340 kb plasmid. It was revealed that the Y. pestis strain I-3536 lost the plasmid pCD1, however, fragments homologous to this plasmid were found in the structure of its genome.Conclusion. The data obtained allow us to recommend Y. pestis I-1 and Y. pestis I-3536 as the basis for the development of a modern live attenuated plague vaccine.
Activation of T-helper in vitro under the Influence of Yersinia pestis Antigens in People Vaccinated against the Plague
Authors: Kozhevnikov V. A. , Kravtsov A. L. , Kudryavtseva O. M. , Kashtanova T. N. , Bugorkova S. A. 
Published: November 2022

Relevance. The search for informative markers for assessing the immunological efficacy of a live plague vaccine remains an urgent scientific task. The goal of the studyAims was to make a comparative assessment of the level helper T-cells activation by CD69 and HLA-DR markers, in people, vaccinated against plague, in an in vitro test, using the disintegrated by ultrasonic Y. pestis cells, grown at temperature 28 °C as a specific stimulator.Materials & Methods. A cytofluorimetric analysis of blood samples of 45 individuals vaccinated against the plague was carried out. The dependence of the result of cytological analysis of the two studied cell markers on the immunoregulatory index (IRI) of the vaccinated donor at the time of vaccination was revealed.Results. It was found that for newly vaccinated individuals, the T-helpers were more intensive and prolonged by the early activation marker, while for those revaccinated with the immunoregulatory index, at the time of vaccination more than 1.5, the more intense cellular response was by the late activation marker.Conclusions. Thus, the possibility of quantitative evaluation of the immunological efficacy of vaccination against plague, based on the identification of lymphocyte activation markers when stimulated with a specific antigen, is confirmed.
Cost-Effectiveness of Pneumococcal Vaccination among Patients with Diabetes Mellitus
Authors: Rudakova A. V. , Briko N. I. , Lobzin Yu. V. , Namazova-Baranova I. S. , Avdeev S. N. , Korshunov V. A. , Kostinov M. P. , Ignatova G. I. , Blinova E. V. , Kontsevaya A. V. , Shepel R. V. , Drozdova I. Yu. , Drapkina O. M. 
Published: November 2022

Relevance. Patients with diabetes mellitus have an increased risk of developing various infections, including those of the lower respiratory tract. Immunization with anti-pneumococcal vaccines reduces pneumonia-related hospitalizations and deaths.Aim. Evaluate the cost-effectiveness of vaccination against pneumococcal infection in 40and 65-year-old patients with type 2 diabetes mellitus (DM2).Material and methods. The analysis was carried out from the perspective of the healthcare system. The Markov model based on Russian epidemiological data, taking into account the results of foreign studies, was used. Vaccination schedules with 1 dose of 13-valent pneumococcal conjugate vaccine (PCV13) followed by 1 dose of pneumococcal 23-valent polysaccharide vaccine (PPV23) and vaccination with only 1 dose of PCV13 were evaluated. The time horizon of the study is 5 years. Costs and life expectancy were discounted by 3.5% per year.Results. Vaccination of 65-year-old patients with type 2 diabetes is characterized by extremely high cost-effectiveness (the incremental cost effectiveness ratio – ICER – for PCV13+PPV23 vaccination is 189.27 thousand rubles/QALY, and PCV13 vaccination entails a cost reduction of 371.92 rubles per 1 vaccinated). When vaccinating 40-year-old patients, the ICER for PCV13 + PPV23 vaccination is 491.31 thousand rubles/QALY, and for PCV13 – 55.31 thousand rubles/QALY.Conclusion. Vaccination against pneumococcal disease in 40and 65-year-old patients with DM2 reduces the associated morbidity and mortality and is highly cost-effective. Compared to PCV13 vaccination alone, vaccination with PCV13 followed by the introduction of PPV23 provides an increase in the number of prevented cases of the disease and the deaths caused by it, but at the same time requires additional costs.
The Reality and Prospects of Pneumococcal Vaccination during the COVID-19 Pandemic
Authors: Orlova E. A. , Dorfman I. P. , Shatalova O. V. , Orlov M. A. , Mamina R. M. , Mochalova N. N. 
Published: November 2022

Relevance. Pneumococcal infection (PI) is one of the leading causes of disability and death of older people worldwide. In the Astrakhan region, as in other regions of the Russian Federation, there is a low coverage of pneumococcal vaccination (PV) and amounts to 1.3% of the adult population. This study reflects the regional problem of PV, an evaluation of its effectiveness in reducing exacerbations and the development of community-acquired pneumonia (CAP) in patients with COPD. The impact of pneumococcal infection (PI) in the development of pneumonia turned out in the period of the COVID-19 pandemic so far to be the most significant.Aim of this work was to evaluate the level of doctor’s awareness in the issues of pneumococcal vaccination, as well as the results of its implementation in patients with COPD during COVID-19 pandemic.Materials and methods. The study was conducted in the form of a survey in the period from October 2021 to February 2022. A survey was conducted through a questionnaire poll in polyclinics and pulmonology departments of multidisciplinary hospitals in Astrakhan. A total of 201 doctors and 173 patients suffering from COPD participated in the study. The doctors' responses were compared with the results of the survey conducted in 2018.Results. This study shows that 26% of the surveyed patients with COPD were vaccinated with pneumococcal vaccine. Analysis of clinical effects after vaccination shows that exacerbations of COPD were absent during the year in 51.1% of vaccinated patients, and 35.2% in non-vaccinated group. The prevalence of CAP in vaccinated patients was 13.3% vs 32.4% in patients who did not receive vaccination.Conclusion. This study showed a significant level of clinical efficacy of PV, characterized by a reduced incidence of COPD exacerbations and the development of VP in vaccinated patients, as well as a lower number of hospitalizations. Vaccinated patients reported mild severity of coronavirus infection, which determines the high prospects for further PV research as one of the important measures to counteract the COVID-19 pandemic. The problem of awareness in specialists about pneumococcal vaccination requires further improvement of educational programs on the relevant topic in the framework of continuing medical education.
Evaluation of Seasonal Inactivated Influenza Vaccines Prophylactic Efficacy
Authors: Zhdanov K. V. , Kasyanenko K. , Mal'cev O. V. , L'vov N. I. , Lioznov D. A. , Lapikov I. I. , Ivanov K. S. 
Published: November 2022

Relevance. Seasonal flu vaccination is still the most effective way to protect against flu viruses and help to reduce the burden of flu illnesses. Another possible benefit is the impact of yearly vaccines on severity of breakthrough infection. In this regard, the issue of choosing safe vaccine with high immunogenicity becomes relevant.Aims. To evaluate the prophylactic efficacy of inactivated seasonal flu vaccines (quadrivalent subunit vaccine with adjuvant and trivalent vaccine) and reactogenicity of quadrivalent vaccine.Materials and methods. 491 cases were included in our study: 152 cases received adjuvanted quadrivalent subunit flu vaccine «Grippol Quadrivalent», 118 cases received trivalent inactivated flu vaccine and 221 cases who have received no vaccinations during 2018–2019 epidemic season.Results. inactivated vaccines showed high prophylactic efficacy in preventing seasonal influenza. Incidence of influenza and other viral respiratory disease cases was lowest in «Grippol Quadrivalent» group. Breakthrough influenza cases in individuals vaccinated with inactivated vaccine were predominantly mild, no severe cases were reported. The early post-vaccination period in «Grippol Quadrivalent» group showed no variation in adverse events with other vaccines.Conclusion. Adjuvanted quadrivalent subunit flu vaccine was the most efficacious in preventing influenza in 2018–2019 epidemic season.
Epidemic Outbreak of COVID-19 in Foreign Closed Long-Term Care Facilities
Authors: Akimkin V. G. , Davydova N. G. , Ugleva S. V. , Ponezheva Zh. B. , Shabalina S. V. 
Published: November 2022

Objective. Of particular interest is the incidence of COVID-19 in closed groups, in institutions, in particular, in nursing homes, geriatric centers, veterans' homes and neuropsychiatric boarding schools.Methods. Analysis and description of COVID-19 foci in closed long-term care facilities was carried out using literature sources from the MEDLINE medical information database using the PubMed electronic search engine, using the search query CARE HOME OR NURSING HOME OR LONG-TERM CARE FACILITY AND COVID-19 AND OUTBREAK. The share of sick people as a percentage of the total number of residents and individual employees was considered only in those publications that described the outbreak of COVID-19 in a single institution. The absence of data on the number of hospitalizations and deaths, symptoms, and data on the time frame of the outbreak was not an exclusion criterion, but their presence was taken into account in the analysis. We selected mainly publications where people with a positive PCR test for SARS-CoV-2 RNA were considered to be ill with COVID-19. However, it is worth considering that the authors describe outbreaks during the first rise in the incidence of COVID-19 in the world, when there was a shortage of test systems for a new coronavirus infection.Results. An overview of the incidence of COVID-19 in the world in closed long-term care institutions is presented. It has been shown that residents of closed communities are elderly people with many concomitant diseases, in connection with which a severe course of COVID-19 and high mortality are often noted.Conclusion. Convictions about the need to strengthen the quality of anti-epidemic measures in closed long-term care institutions, which are at risk, are summarized.