bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-authorisation safety study of burosumab use in paediatric, adolescent and adult patients with X-linked hypophosphataemia: rationale and description
Authors: Brandi Maria Luisa , Ariceta Gema , Beck-Nielsen Signe Sparre , Boot Annemieke M. , Briot Karine , de Lucas Collantes Carmen , Emma Francesco , Giannini Sandro , Haffner Dieter , Keen Richard , Levtchenko Elena , Mӓkitie Outi , Nilsson Ola , Schnabel Dirk , Tripto-Shkolnik Liana , Zillikens M. Carola , Liu Jonathan , Tudor Alina , Mughal M. Zulf 
Published: September 2022

Background: X-linked hypophosphataemia (XLH) is a rare, inherited, phosphate-wasting disorder that elevates fibroblast growth factor 23 (FGF23), causing renal phosphate-wasting and impaired active vitamin D (1,25(OH)2D) synthesis. Disease characteristics include rickets, osteomalacia, odontomalacia, and short stature. Historically, treatment has been oral phosphate and 1,25(OH)2D supplements. However, these treatments do not correct the primary pathogenic mechanism or treat all symptoms and can be associated with adverse effects. Burosumab is a recombinant human immunoglobulin G1 monoclonal antibody against FGF23, approved for treating XLH in several geographical regions, including Europe and Israel. Burosumab restores normal serum phosphate levels, minimising the clinical consequences of XLH. Safety data on long-term treatment with burosumab are lacking owing to the rarity of XLH. This post-authorisation safety study (PASS) aims to evaluate the safety outcomes in patients aged >1 year. Methods: The PASS is a 10-year retrospective and prospective cohort study utilising data from the International XLH Registry (NCT03193476), which includes standard diagnostic and monitoring practice data at participating centres. The PASS aims to evaluate frequency and severity of safety outcomes, frequency and outcomes of pregnancies in female patients, and safety outcomes in patients with mild to moderate kidney disease at baseline, in children, adolescents and adults treated with burosumab for XLH. It is expected that there will be at least 400 patients who will be administered burosumab. Results: Data collection started on 24 April 2019. The expected date of the final study report is 31 December 2028, with two interim reports. Conclusion: This PASS will provide data on the long-term safety of burosumab treatment for XLH patients and describe safety outcomes for patients receiving burosumab contrasted with those patients receiving other XLH treatments, to help inform the future management of XLH patients. The PASS will be the largest real-world safety study of burosumab. Registry identification: The International XLH Registry is registered with clinicaltrials.gov as NCT03193476 ( https://clinicaltrials.gov/ct2/show/NCT03193476 ), and the PASS is registered with the European Union electronic Register of Post-Authorisation Studies as EUPAS32190 ( http://www.encepp.eu/encepp/viewResource.htm?id=32191 ).
The feasibility of an online educational lifestyle program for people with multiple sclerosis: A qualitative analysis of participant semi-structured interviews
Authors: Bevens William , Reece J , Jelinek PL , Weiland TJ , Nag N , Simpson-Yap S , Gray K , Jelinek GA , Neate SL 
Published: September 2022

Objective To explore the feasibility of a randomised controlled trial of a multiple sclerosis online course (MSOC) via qualitative analysis of participant semi-structured interviews. Methods The MSOC was developed in two arms: intervention arm which contained evidence-based lifestyle modification recommendations, and standard-care arm which delivered information from MS websites reflecting standard advice. Participants were recruited via online advertisements, completed a baseline questionnaire, and randomised. Seven modules were delivered over six weeks. Course completers were invited to participate in semi-structured interviews. Within a qualitative paradigm, interviews were analysed using reflexive thematic analysis. Results Fourteen of the 17 course completers were interviewed: 86% (12/14) female; mean age 50 years; residing in Australia, New Zealand, and the USA, predominantly had relapsing-remitting MS, mean time from diagnosis 9.5 years, and patient-determined disease steps disability assessment distributed evenly across all three categories. Four themes were identified: 1) “Hearing our stories” (hope for the future, feeling represented, exploring the journey of others with MS, learning from diversity, and wanting to connect with others); 2) “Taking the plunge” (not wanting to be first, feelings of nervousness or reluctance and feeling confronted); 3) “The accessibility and safety of being online” (ease of access, going at your own pace, making it work and not letting others down); and 4) “unpacking the course” (ease of navigation, visuals, understandability, and length and timing). Conclusion Participants felt represented, found the course accessible and content was easy to understand. These experiences provide important insights and considerations for this digital health intervention.
Accuracy of wrist-worn wearable devices for determining exercise intensity
Authors: Ho Wei-Te , Yang Yi-Jen , Li Tung-Chou 
Published: September 2022

Objective As an indicator of exercise intensity, heart rate can be measured in a timely manner using wrist-worn devices. No study has attempted to estimate a target exercise intensity using wearable devices. The objective of the study was to evaluate the validity of prescribing exercise intensity using wrist-worn devices. Methods Thirty healthy subjects completed a maximal cardiopulmonary exercise test. Their heart rates were recorded using an electrocardiogram and two devices—Apple Watch Series 6 and Garmin Forerunner 945. Exercise intensity with the target heart rate was defined as resting heart rate + (maximal heart rate − resting heart rate) * n% ( n%: 40–60% for moderate-intensity exercise and 60–89% for vigorous-intensity exercise). Heart rate was analyzed at the lower and upper limits of each exercise intensity (HR40, HR60, and HR89). The mean absolute percentage error and concordance correlation coefficient were calculated, and Bland–Altman plots and scatterplots were constructed. Results Both devices showed a low mean absolute error (1.16–1.48 bpm for Apple and 1.35–2.25 for Garmin) and mean absolute percentage error (<1% for Apple and 1.16–1.39% for Garmin) in all intensities. A substantial correlation with electrocardiogram-measured heart rate was observed for moderate to vigorous intensity with concordance correlation coefficient > 0.95 for both devices, except that Garmin showed moderate correlation at the upper limit of vigorous activity with concordance correlation coefficient = 0.936. Moreover, Bland–Altman plots and scatterplots demonstrated a strong correlation without systematic error when the values obtained via the two devices were compared with electrocardiogram measurements. Conclusions Our findings indicate the high validity of exercise prescriptions based on the heart rate measured by the two devices. Additional research should explore other populations to confirm these findings.
Research Development on Fish Swimming
Authors: Liu Yanwen , Jiang Hongzhou 
Published: September 2022

AbstractFishes have learned how to achieve outstanding swimming performance through the evolution of hundreds of millions of years, which can provide bio-inspiration for robotic fish design. The premise of designing an excellent robotic fish include fully understanding of fish locomotion mechanism and grasp of the advanced control strategy in robot domain. In this paper, the research development on fish swimming is presented, aiming to offer a reference for the later research. First, the research methods including experimental methods and simulation methods are detailed. Then the current research directions including fish locomotion mechanism, structure and function research and bionic robotic fish are outlined. Fish locomotion mechanism is discussed from three views: macroscopic view to find a unified principle, microscopic view to include muscle activity and intermediate view to study the behaviors of single fish and fish school. Structure and function research is mainly concentrated from three aspects: fin research, lateral line system and body stiffness. Bionic robotic fish research focuses on actuation, materials and motion control. The paper concludes with the future trend that curvature control, machine learning and multiple robotic fish system will play a more important role in this field. Overall, the intensive and comprehensive research on fish swimming will decrease the gap between robotic fish and real fish and contribute to the broad application prospect of robotic fish.
Kinematics Analysis and Singularity Avoidance of a Parallel Mechanism with Kinematic Redundancy
Authors: Shen Chaoyu , Qu Haibo , Guo Sheng , Li Xiao 
Published: September 2022

AbstractThe kinematic redundancy is considered as a way to improve the performance of the parallel mechanism. In this paper, the kinematics performance of a three degree-of-freedom parallel mechanism with kinematic redundancy (3-DOF PM-KR) and the influence of redundant parts on the PM-KR are analyzed. Firstly, the kinematics model of the PM-KR is established. The inverse solutions, the Jacobian matrix, and the workspace of the PM-KR are solved. Secondly, the influence of redundancy on the PM-KR is analyzed. Since there exists kinematic redundancy, the PM-KR possesses fault-tolerant performance. By locking one actuating joint or two actuating joints simultaneously, the fault-tolerant workspace is obtained. When the position of the redundant part is changed, the workspace and singularity will be changed. The results show that kinematic redundancy can be used to avoid singularity. Finally, the simulations are performed to prove the theoretical analysis.
Exosome application in treatment and diagnosis of B-cell disorders: leukemias, multiple sclerosis, and arthritis rheumatoid
Authors: Karami Fath Mohsen , Azami Jalil , Jaafari Niloofar , Akbari Oryani Mahsa , Jafari Nafiseh , Karim poor Alireza , Azargoonjahromi Ali , Nabi-Afjadi Mohsen , Payandeh Zahra , Zalpoor Hamidreza , Shanehbandi Dariush 
Published: September 2022

AbstractExosomes, known as a type of extracellular vesicles (EVs), are lipid particles comprising heterogeneous contents such as nucleic acids, proteins, and DNA. These bi-layered particles are naturally released into the extracellular periphery by a variety of cells such as neoplastic cells. Given that exosomes have unique properties, they can be used as vectors and carriers of biological and medicinal particles like drugs for delivering to the desired areas. The proteins and RNAs being encompassed by the circulating exosomes in B-cell malignancies are deemed as the promising sources for diagnostic and prognostic biomarkers, as well as therapeutic agents. Exosomes can also provide a “snapshot” view of the tumor and metastatic landscape at any particular time. Further, clinical research has shown that exosomes are produced by immune cells such as dendritic cells can stimulate the immune system, so these exosomes can be used in antitumor vaccines. Despite the great potential of exosomes in the fields of diagnostic and treatment, further studies are in need for these purposes to reach a convergence notion. This review highlights the applications of exosomes in multiple immune-related diseases, including chronic lymphocytic leukemia, multiple sclerosis, and arthritis rheumatoid, as well as explaining sundry aspects of exosome therapy and the function of exosomes in diagnosing diseases.
Predictors of neurological outcome after out-of-hospital cardiac arrest: sex-based analysis: do males derive greater benefit from hypothermia management than females?
Authors: Awad Emad M. , Humphries Karin H. , Grunau Brian E. , Norris Colleen M. , Christenson Jim M. 
Published: September 2022

Abstract
Background
Previous studies of the effect of sex on after out-of-hospital cardiac arrest (OHCA) outcomes focused on survival to hospital discharge and 1-month survival. Studies on the effect of sex on neurological function after OHCA are still limited. The objective of this study was to identify the predictors of favorable neurological outcome and to examine the association between sex as a biological variable and favorable neurological outcome OHCA.

Methods
Retrospective analyses of clustered data from the Resuscitation Outcomes Consortium multi-center randomized controlled trial (2011–2015). We included adults with non-traumatic OHCA and EMS-attended OHCA. We used multilevel logistic regression to examine the association between sex and favorable neurological outcomes (modified Rankin Scale) and to identify the predictors of favorable neurological outcome.

Results
In total, 22,416 patients were included. Of those, 8109 (36.2%) were females. The multilevel analysis identified the following variables as significant predictors of favorable neurological outcome: younger age, shorter duration of EMS arrival to the scene, arrest in public location, witnessed arrest, bystander CPR, chest compression rate (CCR) of 100–120 compressions per minute, induction of hypothermia, and initial shockable rhythm. Two variables, insertion of an advanced airway and administration of epinephrine, were associated with poor neurological outcome. Our analysis showed that males have higher crude rates of survival with favorable neurological outcome (8.6 vs. 4.9%, p < 0.001). However, the adjusted rate was not significant. Further analyses showed that hypothermia had a significantly greater effect on males than females.

Conclusions
Males had significantly higher crude rates of survival with favorable neurological outcome. However, the adjusted rate was not statistically significant. Males derived significantly greater benefit from hypothermia management than females, but this can possibly be explained by differences in arrest characteristics or in-hospital treatment. In-depth confirmatory studies on the hypothermia effect size by sex are required.
Oral to nasal endotracheal tube exchange using tracheal tube guide and video laryngoscope in a pediatric patient with facial burns: a case report
Authors: Yogo Naoki , Sasaki Taeko , Kozumi Masato , Kinoshita Yuya , Muto Yuichiro , Hirai Katsuki , Yoshino Yuichiro 
Published: September 2022

Abstract
Background
Airway management in children with severe burns is difficult because of airway edema and prolonged duration of ventilatory management. There is insufficient evidence to suggest that tracheostomy is beneficial for children.

Case presentation
A male child aged 1 year and 4 months was injured when he accidentally fell into a bathtub filled with boiling water. Furthermore, 85% of the burnt area, including the face and neck, consisted of second-degree burns; hence, oral tracheal intubation and resuscitative infusion were required. In this case, the patient was safely switched from oral to nasotracheal intubation using a tracheal tube guide and video laryngoscope, without the use of a bronchoscope, and ventilatory management could be continued for 2 weeks.

Conclusion
Oral to nasal endotracheal tube exchange using a tracheal tube guide and video laryngoscope may be useful not only for pediatric burn patients but also for adult patients who need to be safely switched from oral to nasotracheal intubation.
An update on efficacy and safety of alpha-blockers in the treatment of distal ureteric stones: narrative review
Authors: K Shreyas , L Ananthesh , Sathish Varshini , Achar M Ujwala , Raj K C Bharath , Pai Narendra 
Published: September 2022

Abstract
Background
Alpha-blockers prescribed as medical expulsion therapy (MET) have replaced minimally invasive procedures as the primary line of treatment for minor ureteric stones. This study aims to investigate the efficacy of MET with alpha-blockers in terms of stone expulsion rate and time and evaluate the safety of several alpha-blockers.

Methodology
Google Scholar, PubMed, and Web of Science databases were searched for relevant publications using keywords published between December 2013 and August 2021. Additional relevant research was found by looking through the references in the articles.

Results
To determine the efficacy and safety of alpha-blockers as a medical expulsive therapy for the management of distal ureteral stones, 15 studies were included, 12 randomized control trials, 2 retrospective observational studies, and 1 prospective study. The most commonly studied primary endpoint was stone expulsion rate and time. According to findings, silodosin appears to be more effective than other alpha-blockers. The data revealed no life-threatening adverse effects were associated with alpha-blockers.

Conclusion
Alpha-blockers are recommended as the first-line therapy for distal ureteral stones. Silodosin was the most efficacious medicine, according to the data. The side effects of alpha-blockers, on the other hand, were minor, consisting primarily of orthostatic hypotension. The alpha-blocker choice differs from urologist to urologist in the management of MET, depending on their experience and the patient's condition.
Transcriptome profiling in rice reveals a positive role for OsNCED3 in defense against the brown planthopper, Nilaparvata lugens
Authors: Sun Litong , Li Jitong , Liu Yongyan , Noman Ali , Chen Lin , Liu Jinglan 
Published: September 2022

Abstract9-cis-epoxycarotenoid dioxygenase (NCED) is the rate-limiting enzyme for abscisic acid (ABA) biosynthesis in higher plants. In rice, OsNCED3 was shown to promote ABA synthesis, and improve abiotic stress tolerance, but the function of OsNCED3 in regulating rice defense against the brown planthopper (Nilaparvata lugens; BPH) has been unclear. In this study, several parameters were used to assess rice resistance to BPH, including the average injury level, the functional plant loss index, and electrical penetration graph analysis. Rice lines overexpressing OsNCED3 (OE) were more resistant to BPH than the wild-type cv. Zhonghua11 (WT). Transcriptome analysis was performed on WT, OE, and a RNAi transgenic line silenced for OsNCED3; these three lines were either infested or non-infested with BPH. Seventeen RNA libraries were compared, and most of the differentially expressed genes (DEGs) were upregulated. The number of DEGs in the RNAi line infested with BPH was significantly higher than the OE, and WT lines, and many DEGs were related to the stress response, and biosynthesis of jasmonic acid. This study shows that overexpression of OsNCED3 in rice improves resistance to BPH, and has potential merit in rice breeding programs.
Elevated serum ferritin levels are associated with severity and prognosis of severe acute pancreatitis: a preliminary cohort study
Authors: Wang Jie , Liu Qing-xie , Teng Dong-ling , Ding Yan-bing , Lu Guo-tao , Gong Wei-juan , Zhu Qing-tian , Han Fei , Xiao Wei-ming 
Published: September 2022

AbstractBackgroundSerum ferritin (SF), as an acute-phase response protein, is used to reflect the degree of oxidative stress and systemic inflammatory responses. This study was designed to assess the effect of elevated SF levels on the severity of acute pancreatitis (AP).MethodsFrom January 2013 to December 2020, 200 consecutive patients with AP were retrospectively reviewed to analyze the relationships among the etiologies of pancreatitis, the severity of the disease and SF levels. The receiver operating characteristic (ROC) curve and logistic regression analysis were used to assess whether elevated SF levels could predict the onset of organ failure in AP.Results92 (46%) had high SF levels (> 275 ng/ml). SF levels were not associated with the etiology of AP disease. Among patients with high SF levels, there was a significant increase in the proportion of patients with severe AP (23.1% vs. 76.9%) and a higher proportion of systemic inflammatory response scores (25.9% vs. 44.6%) in comparison to patients with normal SF levels. The area under the ROC curve for SF in predicting persistent organ failure was 0.812 [95% confidence interval 0.721–0.904].ConclusionsF concentrations were positively correlated with the severity of AP, and quantitative assessment of SF can predict disease severity and organ failure in patients with AP.
Concomitant Guillain–Barré Syndrome in a young Sri Lankan male with severe ulcerative colitis
Authors: Jayasundara Jayasundara Mudiyanselage Hishali D , Samarawickrama Vajira Tharanga , Peiris Ranjith , Aponso Tilan , Abeynayake Danushi 
Published: September 2022

Abstract
Background
Guillain–Barré Syndrome is an immune mediated polyneuropathy. Ulcerative Colitis is an immune mediated chronic inflammatory condition mainly of the large intestine. Guillain–Barré Syndrome can present as a rare extraintestinal manifestation of Ulcerative Colitis when in remission or in a relapse. However, the concomitant presentation of Guillain–Barré Syndrome during a relapse of Ulcerative Colitis is very rare and only a few cases are reported to date.

Case presentation
A 24 year old young male diagnosed of Ulcerative Colitis presented with bloody diarrhea of frequency more than six times a day. He had been in clinical remission even after defaulting treatment for more than a year. He had also noted difficulty in walking prior to admission to the hospital. He was managed as for a severe relapse of Ulcerative Colitis and Guillain–Barré Syndrome. Appropriate management of both the illnesses helped him to recover.

Conclusion
Immune mediated diseases can have rare coexisting presentations. We report a case of Ulcerative Colitis with concomitant Guillain–Barré Syndrome. It is essential to be open minded and timely, appropriate treatment led to successful management of both the illnesses.
Association between HIV duration and symptom distress among middle-aged and elderly people with HIV-infected in China: a cross-sectional study
Authors: Xie Meilian , Wang Aiping , Wang Kerong , Yu Yanping , Lin Zhaoxia 
Published: September 2022

Abstract
Background
Debate has persisted regarding whether PLWH with longer HIV durations have lower levels of prevalence and severity of symptoms compared with their newly diagnosed counterparts. Whether and how the HIV duration impact the symptom distress among middle-aged and older PLWH has not been explored clearly.

Methods
The patients with HIV-infected aged more than 40 years old were included from seven designated medical institutions of seven regions in China. Outcome was the score of symptom distress. We used the multiple regression model to calculate adjusted Coefficient of Regression (β) with 95% CI in this study.

Results
Among 210 participants (mean age 50.8 years; 71.0% male; 68.1% at asymptomatic stage) in the study, the median number of symptoms was 5. Of all symptoms reported, the most distressed symptoms were sleep disturbance (33.33%), followed by memory loss (31.90%), fatigue (26.67%), slow reactions (22.86%), and vision blur (21.90%). All participants were divided into four groups according to HIV duration, and the median of total score of symptom ditress among all participants was 0.1(0.0,0.9). Difference of total scores and clusters’ scores of symptom distress among four HIV duration groups were statistically significant. 51 participants with 6–10 years HIV duration were more likely to be higher level of education, at asymptomatic stage and have higher CD4 + T cell count. After adjustment for gender, age, race, education, marital status, employment, family income, region, stage of disease and CD4 + T cell count, the score of symptom distress among participants with 6–10 years HIV duration had was higher with the extension of HIV duration. Specially in physical symptoms and psychological symptoms,participants with 6–10 years HIV duration reported the persisting worse burdensome.

Conclusions
HIV duration with 6–10 yearsmay be a key period that the medical team needs to pay special attention to among middle-aged and elderly PLWH. There is a need to provide medical and psychosocial services targeting middle-aged and elderly PLWH according to their changing symptom distress.

Trial registration
Clinicaltrials.gov: ChiCTR2100046225. Registered 11 May 2021.