bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natriuretic Peptides, Extracellular Volume, and Subclinical Cardiovascular Changes in Chronic Kidney Disease Stages 1–3: A Pilot Study
Authors: Gregg L Parker , Van Buren Peter N , Ramsey David J , Maydon Amaris , Banerjee Subhash , Walther Carl P , Virani Salim S , Winkelmayer Wolfgang C , Navaneethan Sankar D , Hedayati S Susan 
Published: July 2022

Natriuretic peptide levels are elevated in persons with chronic kidney disease (CKD) stages 1–3, but it remains unclear whether this is associated with extracellular volume excess or early cardiovascular changes. We hypothesized that patients with CKD stages 1–3 would have evidence of cardiovascular changes, which would associate with brain natriuretic peptide (BNP), amino-terminal-pro-BNP (NT-pro-BNP), and patient-reported symptoms. Outpatients with CKD stages 1–3 and non-CKD controls were enrolled. Cardiovascular parameters included extracellular water (ECW) normalized to body weight measured using whole-body multifrequency bioimpedance spectroscopy, and total peripheral resistance index (TPRI) and cardiac index measured by impedance cardiography. Dyspnea, fatigue, depression, and quality of life were quantified using questionnaires. Among 21 participants (13 with CKD), median (IQR) BNP was 47.0 (28.0–302.5) vs 19.0 (12.3–92.3) pg/mL, p=0.07, and NT-pro-BNP was 245.0 (52.0–976.8) vs 26.0 (14.5–225.8) pg/mL, p=0.08, in the CKD and control groups, respectively. Those with CKD had higher pulse pressure (79 (66–87) vs 64 (49–67) mm Hg, p=0.046) and TPRI (3721 (3283–4278) vs 2933 (2745–3198) dyn×s/cm5/m2, p=0.01) and lower cardiac index (2.28 (2.08–2.78) vs 3.08 (2.43–3.37) L/min/m2, p=0.02). In the overall cohort, natriuretic peptides correlated with pulse pressure (BNP r=0.59; NT-pro-BNP r=0.58), cardiac index (BNP r=−0.76; NT-pro-BNP r=−0.62), and TPRI (BNP r=0.48), p<0.05 for each, but not with ECW/weight. TPRI and blood pressure correlated moderately with symptoms. Elevated natriuretic peptides may coincide with low cardiac index and elevated peripheral resistance in patients with CKD stages 1–3. The role of these biomarkers to detect subclinical cardiovascular changes needs to be further explored.
Predation patterns on the tundra—genetic barcoding of scats from two sympatric fox species
Authors: Wilkinson Caitlin , Vigués Jan , Angerbjörn Anders , Norén Karin 
Published: July 2022

In the Arctic tundra, climate-induced emergence of the red fox ( Vulpes vulpes (Linnaeus, 1758)), a competitor to the Arctic fox ( Vulpes lagopus (Linnaeus, 1758)), is predicted to influence predation patterns of both fox mesopredators. In this study, we (i) identified predator species from scats through an established barcoding approach and (ii) explored the use of a cheap, quick barcoding method of fox feces ( n = 103). We investigated differences in diet between the red fox (predicted generalist predator) and Arctic fox (predicted specialist predator) over 2 years with varying prey abundance. We amplified short DNA fragments (<200 bp) from small rodents, birds and hares. For both predators, there was a high frequency of occurrence of rodents (38%–69%) identifying them as primary prey species and birds as secondary prey species (13%–31%). This demonstrates the strength of a straightforward DNA barcoding method for dietary analyses in sympatric fox predators, with species-level resolution of prey. Barcoding is a promising tool for future dietary studies; however, a few methodological improvements, along with extended sampling, are needed for a more complete assessment of fox predation patterns. Integrating high-resolution dietary analyses have great potential to enhance our understanding of predation patterns in Arctic tundra communities.
A revised hydrogeological conceptual model of the Fell Sandstone aquifer, Northumberland and its impact on the interpretation of long-term nitrate trends
Authors: Dearlove Jeremy P. L. , Swartz Melissa 
Published: July 2022

Northumbrian Water abstract groundwater from the Fell Sandstone Formation (part of the Carboniferous Border Group) in north Northumberland, which is a groundwater-only water resource zone providing drinking water to Berwick-upon-Tweed and the surrounding area.
Groundwater in observation and abstraction boreholes shows significant rising nitrate levels derived from agricultural land use, and are predicted to have an impact on groundwater quality by 2030. Northumbrian Water policy is to use catchment management techniques to mitigate rising nitrate levels through influencing land-use practices and reducing nitrate concentration in groundwater recharge. This paper demonstrates how a detailed geological and hydrogeological understanding of the area has been used to identify specific areas where appropriate catchment management techniques may be most effectively applied.
Northumbrian Water and the Environment Agency jointly funded the British Geological Survey to develop a numerical groundwater model of the Fell Sandstone aquifer and to undertake a review of the geology of the Fell Sandstone Formation as part of a Water Industry National Environment Programme (WINEP). Combining the results of these two studies, supported by spatial and temporal field measurements of groundwater nitrate levels, an improved understanding of the potential fate and transport of nitrate in the Fell Sandstone aquifer has emerged. This allows a better prediction of the spatial and temporal impacts of nitrate losses from the soil zone to the aquifer in support of a catchment management approach to mitigating rising nitrate levels.

Thematic collection:
This article is part of the Hydrogeology of Sandstone collection available at:
https://www.lyellcollection.org/cc/hydrogeology-of-sandstone
Design of Wideband Circular-Slot Antenna for Harvesting RF Energy
Authors: Muhammad Surajo , Smida Amor , Waly Mohamed Ibrahim , Mallat Nazih Khaddaj , Iqbal Amjad , Reza Khan Sadeque , Alibakhshikenari Mohammad 
Published: July 2022

The design of a wideband circular-slot antenna for RF signal harvesting is reported in this work. The proposed design frequency range accommodates the leading contributors to the available RF signals accessible by the RFEH node. These widely utilized frequency bands comprise GSM1800, UMTS2100, Wi-Fi2.450, and LTE2600. The antenna geometry comprises circular-ring radiating component filled with two orbital circular and rectangular slots. At the bottom plane, a pair of rectangular and semirectangular-circle slits are integrated. The antenna presented is designed on a double layer of 1.6 mm high FR-4 substrate. The source antenna achieved a simulated and measured impedance bandwidth (BW) of 1.510 and 1.590 GHz, amounting to 68% and 73% fractional BW (FBW), covering -10 dB reflection coefficient (|S11|) between 1.640 to 3.150 GHz and 1.550 to 3.140 GHz, in that order. The wideband circular-slot source antenna realized a maximum measured gain of 1.88, 2.13, 2.81, 3.22, and 4.32 dBi for 1.800, 2.100, 2.450, 2.650, and 3.20 GHz, respectively. The proposed design dimension on the printed board is 0.61

λ

g

× 0.70

λ

g

. The improved antenna gain is obtained from a circular parasitic patch coupled to the defected ground structure (DGS) for better RF energy harvesting in an ambient environment.
Investigative Study on Convective Heat Transfer inside Compartment during Fire Situation
Authors: Mvogo Philippe Onguene , Zatao Samedi Olivier , Patrice Changement  , Zaida Justin Tégawendé , Nzie Wolfgang , Fouda Henri Ekobena , Mouangue Ruben 
Published: July 2022

According to the geometry of compartments, quantities of smokes released during fire tend to accumulate at ceiling so as to form a cloud of hot gases. Heat transfer between these hot gases and walls is decisive for the development of fire. An increase in temperature of these gases could lead to dangerous phenomena such as flashovers and backdrafts. Owing to experiments and numerical simulation, the objective of the present paper is to investigate on the influence of natural ventilation on convective heat transfer between hot gases and walls of a room in fire. So, varying the ventilation level, it was firstly about to carry out fire tests in an experimental room. Secondly, study was focused on the numerical simulation of these tests so as to estimate velocity field of burnt gases near walls during fire. Validation of numerical results has been done by confronting simulated results to experimental results. A full-scale extrapolation of results enabled revealing that while the ventilation level in the room changes, the amplitude of convective heat transfer changes according to the regime of fire. It was shown that for the fuel-controlled fire, the convective heat transfer coefficient strongly increases with the ventilation factor, and for the ventilation-controlled fire, convective heat transfer coefficient weakly decreases with the ventilation factor and remains nevertheless close to value

8.75
W
⋅

m

−
2

⋅

K

−
1

.
Ecdysoneless Overexpression Drives Mammary Tumorigenesis through Upregulation of C-MYC and Glucose Metabolism
Authors: Mohapatra Bhopal C. , Mirza Sameer , Bele Aditya , Gurumurthy Channabasavaiah B. , Raza Mohsin , Saleem Irfana , Storck Matthew D. , Sarkar Aniruddha , Kollala Sai Sundeep , Shukla Surendra K. , Southekal Siddesh , Wagner Kay-Uwe , Qiu Fang , Lele Subodh M. , Alsaleem Mansour A. , Rakha Emad A. , Guda Chittibabu , Singh Pankaj K. , Cardiff Robert D. , Band Hamid , Band Vimla 
Published: July 2022

Abstract

Ecdysoneless (ECD) protein is essential for embryogenesis, cell-cycle progression, and cellular stress mitigation with an emerging role in mRNA biogenesis. We have previously shown that ECD protein as well as its mRNA are overexpressed in breast cancer and ECD overexpression predicts shorter survival in patients with breast cancer. However, the genetic evidence for an oncogenic role of ECD has not been established. Here, we generated transgenic mice with mammary epithelium-targeted overexpression of an inducible human ECD transgene (ECDTg). Significantly, ECDTg mice develop mammary hyperplasia, preneoplastic lesions, and heterogeneous tumors with occasional lung metastasis. ECDTg tumors exhibit epithelial to mesenchymal transition and cancer stem cell characteristics. Organoid cultures of ECDTg tumors showed ECD dependency for in vitro oncogenic phenotype and in vivo growth when implanted in mice. RNA sequencing (RNA-seq) analysis of ECDTg tumors showed a c-MYC signature, and alterations in ECD levels regulated c-MYC mRNA and protein levels as well as glucose metabolism. ECD knockdown-induced decrease in glucose uptake was rescued by overexpression of mouse ECD as well as c-MYC. Publicly available expression data analyses showed a significant correlation of ECD and c-MYC overexpression in breast cancer, and ECD and c-MYC coexpression exhibits worse survival in patients with breast cancer. Taken together, we establish a novel role of overexpressed ECD as an oncogenesis driver in the mouse mammary gland through upregulation of c-MYC–mediated glucose metabolism.

Implications:
We demonstrate ECD overexpression in the mammary gland of mice led to the development of a tumor progression model through upregulation of c-MYC signaling and glucose metabolism.
Black Hole: Using Black Hole Theory and General Relativity to Create a Data-Driven Light and Sound Sculpture
Authors: Kranidiotis Yiannis 
Published: July 2022

Abstract
Black Hole is a data-driven light and sound sculpture inspired by the theory and the geometry of black holes. The terrifying boundaries of the event horizon, the point of no return, and the unbearable confinement of singularity are marked on the sculpture using an intangible medium, light. Sound translates distant gravitational waves into our humanly detectable domain, allowing us to sense the presence of the black hole. In this article, the artist investigates the inspiration he draws from the philosophical aspect of Einstein’s general relativity theory and black holes and describes the creative process of using the bending of space and time to form a sculpture.
Castles versus Cheerleaders: The Clash of Old and New Power Values and Their Effect on the Role of the Conductor
Authors: Clarke Majella 
Published: July 2022

Abstract
All forms of leadership are currently undergoing change, as digitalization, democratization, and increased transparency have led to a shift in social values and a realignment of influence disassociated from power. Power is shifting in the world; old leadership models are clashing with new leadership models. The article presents an analysis of the role of the conductor using the new power compass framework to discuss the drivers of change in the future of ensemble and orchestral direction and their programming to support diversity and inclusion.
A Strata-Based Approach to Discussing Artistic Data Sonification
Authors: Mardakheh Milad Khosravi , Wilson Scott 
Published: July 2022

Abstract
Much discussion surrounding data sonification for musical and artistic purposes focuses on seeming contradictions that arise from the ways in which this practice differs from that of data sonification as a scientific tool. Over the past 30 years, this debate has become a rabbit hole of questions and arguments regarding the nature of music/sound-art and data sonification, and of their relationships with one another. In the following article, the authors identify three areas/classifications of artistic sonification, using a “strata” metaphor with the hope of bringing clarity to this discussion, as well as enabling reflection on the nature of science-art collaborations using this approach.
A Transdisciplinary Approach in Art: Translating Physical Trauma into a Geographic Map
Authors: Peycheva Aksiniya 
Published: July 2022

Abstract
A transdisciplinary exploration has allowed the author to combine art, hematology, computer science, and geography to attempt the visual translation of physical pain. Research subjects are stray animals that have experienced traumatic events (such as shooting) which have a lasting impact on their lives or, at times, prove to be fatal. By applying different computational geometry methods, the author creates geographic maps, which reveal the scale of the damage to the body. Thus, the application of transdisciplinarity allows a deeper understanding of complex events.
Moving the International Court of Justice from Bilateralism to Serving the Community Interest – A Proposal to Refrain from Being a ‘National Judge’
Authors: Kirchmair Lando 
Published: July 2022

Abstract
Empirical analysis shows that judges at the International Court of Justice (ICJ) tend to vote (85 to 90%) for their country of nationality. In order to outweigh this imbalance – already predicted in 1920 when drafting the Statute of the Permanent Court of International Justice (PCIJ), the predecessor of the ICJ – the decision was taken to allow states which do not have a permanent judge of their nationality on the bench to nominate a judge ad hoc. The nationality bias is an important legitimacy issue for the Court. Inspired by Judge Thomas Buergenthal’s public appeal and along the lines of Judge Bruno Simma’s finding on the shift from ‘bilateralism to community interest in international law’, this article submits that a national judge at the ICJ should refrain from being a national judge by recusing herself when her home country is party to a case. In doing so she could protect herself from this nationality bias, which is a severe threat to (the appearance of) her impartiality and independence. Arguably, some one hundred years after the decision was taken against mandatory recusal on the basis of nationality when the Statute of the PCIJ was drafted, the international community is now demanding that individual judges of the principal judicial organ of the United Nations serve the community interest independently and impartially.
Prolegomena to a New Methodological Approach to the Pagan Divine Man (θεῖος ἀνήρ) in Late Antiquity
Authors: Alviz Fernández Marco 
Published: July 2022

Abstract
With this article I propose a new methodological approach in the field of pagan divine men studies in late antiquity. The “Divine Men” were the last representatives of ancient παιδεία (education) in a context where religion, education, and philosophy were inextricably intertwined. Decades of scholarly claims bring the research path towards a multidisciplinary focus in which I suggest applying the Weberian concept of charisma from a social history perspective. Thus, this preliminary research puts forward a new heuristic and hermeneutical method to better understand the social processes that those communities influenced.
Christmas and Revolution
Authors: Melnychenko Oleh 
Published: July 2022

Abstract
The discourse of the Ukrainian Revolution of Dignity (2013–2014) abundantly adopted religious themes. In my article, I show how the theme of Christmas, with its specific images and vocabulary, has been used in the rhetoric of the participants of the Revolution. In three sections, I demonstrate the three lines in which the protesters, speakers, and commenters drew parallels between the course of the Revolution and the Nativity story. These lines are the birth of Christ, the persecutions of Herod, and the Bethlehem infanticide. Finally, I show how the protesters killed at the end of the Revolution are represented in the post-Maidan discourse as national saints. I devote special attention to the Christmas play called Vertep, performed on the Maidan scene in the winter of 2013–2014, because it most fully embraces the link between these lines and the Revolution. The results of the study are intended to contribute to a better understanding of both phenomena: the Revolution of Dignity as an event, influenced by religion, and the Ukrainian Christmas tradition as a flexible and ever-renewable source for the conceptualization of social reality.
Reduced ENSO Variability due to a Collapsed Atlantic Meridional Overturning Circulation
Authors: Orihuela-Pinto Bryam , Santoso Agus , England Matthew H. , Taschetto Andréa S. 
Published: July 2022

Abstract
Atlantic meridional overturning circulation (AMOC) collapses have punctuated Earth’s climate in the past, and future projections suggest a weakening and potential collapse in response to global warming and high-latitude ocean freshening. Among its most important teleconnections, the AMOC has been shown to influence El Niño–Southern Oscillation (ENSO), although there is no clear consensus on the tendency of this influence or the mechanisms at play. In this study, we investigate the effect of an AMOC collapse on ENSO by adding freshwater in the North Atlantic in a global climate model. The tropical Pacific mean-state changes caused by the AMOC collapse are found to alter the governing ENSO feedbacks, damping the growth rate of ENSO. As a result, ENSO variability is found to decrease by ∼30% due to weaker air–sea coupling associated with a cooler tropical Pacific and an intensified Walker circulation. The decreased ENSO variability manifests in ∼95% less frequent extreme El Niño events and a shift toward more prevalent central Pacific El Niño than eastern Pacific El Niño events, marked by a reduced ENSO nonlinearity and asymmetry. These results provide mechanistic insights into the possible behavior of past and future ENSO in a scenario of a much weakened or collapsed AMOC.

Significance Statement
The Atlantic meridional overturning circulation (AMOC) has collapsed in the past and a future collapse due to greenhouse warming is a plausible scenario. An AMOC shutdown would have major ramifications for global climate, with extensive impacts on climate phenomena such as El Niño–Southern Oscillation (ENSO), which is the strongest source of year-to-year climate variability on the planet. Using numerical simulations, we show that an AMOC shutdown leads to weaker ENSO variability, manifesting in 95% reduction in extreme El Niño events, and a shift of the ENSO pattern toward the central Pacific. This study sheds light on the mechanisms behind these changes, with implications for interpreting past and future ENSO variability.
Study of the value of homocysteine levels in predicting cognitive dysfunction in patients after acute carbon monoxide poisoning
Authors: Ren Wei , Zhou Xiao Shuai 
Published: July 2022

Abstract
Purpose
The purpose of this research was to assess the value of homocysteine (HCY) levels in predicting cognitive dysfunction in patients after acute carbon monoxide (CO) poisoning.

Methods
A total of 115 patients who were admitted to the emergency department of Yinzhou NO. 2 Hospital after CO poisoning between January 2017 and December 2021 were enrolled in this retrospective study. All patients were followed up for 1 month. According to the Mini–Mental State Examination (MMSE) scores, patients were divided into two groups. The demographic and clinical characteristics and magnetic resonance imaging (MRI) results were gathered and statistically analysed.

Results
Twenty-six and 89 patients were ultimately enrolled in the cognitive dysfunction and control groups, respectively. There were significant differences between the groups in terms of age, coma duration, and carboxyhaemoglobin (COHB), lactate and HCY levels (p < 0.05), but there were no significant differences in white blood cell (WBC) counts or aspartate transaminase (AST), alanine transaminase (ALT), creatinine, troponin T, creatinine kinase (CK), or creatinine kinase muscle and brain (CK-MB) levels (p > 0.05). Univariate and multivariate analyses identified that a higher HCY level (OR 2.979, 95% CI 1.851-5.596, p < 0.001) was an independent risk factor for patient cognitive dysfunction after acute CO poisoning. Linear regression analysis showed a negative correlation between MMSE scores and HCY levels (r = − 0.880, P < 0.001). According to the MRI results, the most common lesion site was the globus pallidus, and the central ovale, diffuse white matter, corona radiata, basal ganglia (other than the globus pallidus) and cerebral cortex were also involved.

Conclusions
Higher HCY levels were associated with cognitive impairment and were independent risk factors for cognitive impairment after acute CO poisoning. The level of HCY was negatively correlated with the degree of cognitive impairment.