bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corilagin exhibits differential anticancer effects through the modulation of STAT3/5 and MAPKs in human gastric cancer cells
Authors: Yang Min Hee , Baek Seung Ho , Hwang Sun Tae , Um Jae‐Young , Ahn Kwang Seok 
Published: March 2022

AbstractCorilagin (CLG) is a hydrolyzable tannin and possesses various pharmacological activities. Here, we investigated the impact of CLG as an anti‐tumor agent against human gastric tumor cells. We observed that CLG could cause negative regulation of JAKs‐Src‐STAT3/5 signaling axis in SNU‐1 cells, but did not affect these pathways in SNU‐16 cells. Interestingly, CLG promoted the induction of mitogen‐activated protein kinases (MAPKs) signaling pathways in only SNU‐16 cells, but not in the SNU‐1 cells. CLG exhibited apoptotic effects that caused an increased accumulation of the cells in sub‐G1 phase and caspase‐3 activation in both SNU‐1 and SNU‐16 cell lines. We also noticed that CLG and docetaxel co‐treatment could exhibit significantly enhanced apoptotic effects against SNU‐1 cells. Moreover, the combinations treatment of CLG and docetaxel markedly inhibited cell growth, phosphorylation of JAK‐Src‐STAT3 and induced substantial apoptosis. Additionally, pharmacological inhibition of JNK, p38, and ERK substantially blocked CLG‐induced activation of MAPKs, cell viability, and apoptosis, thereby implicating the pivotal role of MAPKs in the observed anti‐cancer effects of CLG. Taken together, our data suggest that CLG could effectively block constitutive STAT3/5 activation in SNU‐1 cells but induce sustained MAPKs activation in SNU‐16 cells.
EDTA Modified Hollow Microporous Organic Nanospheres for Enhancing Adsorption of Metal Ions
Authors: Ni Shujing , Ge Qi , Yu Haitao , Zhang Li , Wu Wenjin , Song Chunmei , Huang Kun 
Published: March 2022

AbstractIn this study, ethylenediaminetetraacetic acid (EDTA) modified hollow microporous organic nanospheres (EDTA‐HMONs‐BA) were prepared by a combination of one‐pot hyper‐crosslinking mediated self‐assembly using polylactide‐b‐polystyrene (PLA‐b‐PS) diblock copolymer and benzylamine (BA) monomers as precursors and subsequent post‐modification with EDTA. The obtained EDTA‐HMONs‐BA were characterized by FT‐IR, TEM, TGA, solid state 13C NMR, N2 adsorption‐desorption test et al. It revealed that the EDTA‐HMONs‐BA have a high specific surface area (226.86 m2 g−1), which exhibited excellent adsorption ability for Cu2+ ions (236 mg g−1) with adsorption characteristics of pseudo‐second‐order model and Langmuir isotherm equation. Moreover, the obtained adsorbent is of high stability after five consecutive cycles. Besides, EDTA‐HMONs‐BA also showed good adsorption capacities for hard acid metal ions (Cr3+), soft acid metal ions (Ag+, Cd2+), borderline acid metal ions (Cu2+, Ni2+, Zn2+). The above results indicated that the EDTA‐HMONs‐BA can be considered as potential adsorbents for the removal of heavy‐metal ions owing to the easily accessible adsorption sites and sufficiently good stability.
Magnetically Actuated Cell‐Robot System: Precise Control, Manipulation, and Multimode Conversion
Authors: Dai Yuguo , Jia Lina , Wang Luyao , Sun Hongyan , Ji Yiming , Wang Chutian , Song Li , Liang Shuzhang , Chen Dixiao , Feng Yanmin , Bai Xue , Zhang Deyuan , Arai Fumihito , Chen Huawei , Feng Lin 
Published: March 2022

AbstractBorder‐nearing microrobots with self‐propelling and navigating capabilities have promising applications in micromanipulation and bioengineering, because they can stimulate the surrounding fluid flow for object transportation. However, ensuring the biosafety of microrobots is a concurrent challenge in bioengineering applications. Here, macrophage template‐based microrobots (cell robots) that can be controlled individually or in chain‐like swarms are proposed, which can transport various objects. The cell robots are constructed using the phagocytic ability of macrophages to load nanomagnetic particles while maintaining their viability. The robots exhibit high position control accuracy and generate a flow field that can be used to transport microspheres and sperm when exposed to an external magnetic field near a wall. The cell robots can also form chain‐like swarms to transport a large object (more than 100 times the volume). This new insight into the manipulation of macrophage‐based cell robots provides a new concept by converting other biological cells into microrobots for micromanipulation in biomedical applications.
Hollow Cuprous Oxide@Nitrogen‐Doped Carbon Nanocapsules for Cascade Chemodynamic Therapy
Authors: Meng Xiangfu , Zhou Ke , Qian Yong , Liu Hongji , Wang Xingyu , Lin Yefeng , Shi Xinyi , Tian Yu , Lu Yijun , Chen Qianwang , Qian Junchao , Wang Hui 
Published: March 2022

AbstractCuprous‐based nanozymes have demonstrated great potential for cascade chemodynamic therapy (CDT) due to their higher catalytic efficiency and simple reaction conditions. Here, hollow cuprous oxide@nitrogen‐doped carbon (HCONC) dual‐shell structures are designed as nanozymes for CDT oncotherapy. This HCONC with a size distribution of 130 nm is synthesized by a one‐step hydrothermal method using cupric nitrate and dimethyl formamide as precursors. The thin‐layer carbon (1.88 nm) of HCONC enhances the water‐stability and reduces the systemic toxicity of cuprous oxide nanocrystals. The dissolved Cu+ of HCONC in acid solution induces a Fenton‐like reaction and exhibits a fast reaction rate for catalyzing H2O2 into highly toxic hydroxyl radicals (·OH). Meanwhile, the formed Cu+ consumes oversaturated glutathione (GSH) to avoid its destruction of ROS at the intracellular level. In general, both cellular and animal experiments show that HCONC demonstrates excellent antitumor ability without causing significant systemic toxicity, which may present tremendous potential for clinical cancer therapy.
Student and advisor gender identity in STEM doctoral programs: Examining longitudinal and mediating effects with latent growth models
Authors: Blaney Jennifer M. , Feldon David F. , Litson Kaylee 
Published: March 2022

AbstractWhile previous research documents that women in STEM doctoral programs tend to fare better when their advisor shares their gender identity, this study provides new insights into the role of student–advisor gender identity congruence, relying on a longitudinal sample of doctoral students in biology and using structural equation and latent growth curve modeling. Findings show that advisor gender played an inconsistent and typically indirect role in predicting student outcomes. Further, all students, regardless of gender, tended to report higher quality advising when their advisor was a woman, pointing to potential gender inequities in advising expectations of faculty. Implications for research, theory, and practice are discussed.
Predictive value of Milan ultrasound criteria in ulcerative colitis: A prospective observational cohort study
Authors: Allocca Mariangela , Dell’Avalle Cecilia , Craviotto Vincenzo , Furfaro Federica , Zilli Alessandra , D’Amico Ferdinando , Bonovas Stefanos , Peyrin‐Biroulet Laurent , Fiorino Gionata , Danese Silvio 
Published: March 2022

AbstractBackgroundEndoscopic healing is an established treatment target for ulcerative colitis (UC). We have recently validated the Milan ultrasound criteria (MUC) to assess endoscopic activity in UC; a MUC score > 6.2 is a valid cut‐off to discriminate endoscopic activity (Mayo endoscopic subscore > 1).ObjectiveThe aim of this study was to assess the predictive value of MUC on disease course in a prospective cohort of UC patients.MethodsUC patients regardless of disease activity and current therapy, underwent colonoscopy and bowel ultrasound (US) at baseline in a blinded fashion. Correlations between baseline MUC and Mayo endoscopic subscore were assessed using Spearman's rank correlation. UC‐related negative course (defined as the need for corticosteroids, or treatment escalation, or hospitalization, or need for colectomy: a composite outcome) over a median 20 months follow‐up, was investigated using the Kaplan‐Meier method and Cox regression analysis.Results98 UC patients were followed up for a median time of 1.6 years (IQR 0.9¬2.7). Milan ultrasound criteria and Mayo endoscopic subscore significantly correlated at baseline (ρ = 0.653; p < 0.001). 70 patients (71%) had negative disease course during the follow‐up period. Milan ultrasound criteria > 6.2 at baseline was statistically significantly associated with negative disease course (HR: 3.87, 95% CI: 2.25–6.64, p < 0.001). Kaplan–Meier analyses drawed a statistically significantly lower cumulative probability of treatment escalation, need of corticosteroids, hospitalization and colectomy, among patients who had MUC ≤ 6.2 at baseline as compared to patients with MUC > 6.2 (p < 0.05 for all outcomes).Conclusionwe have demonstrated for the first time the value of bowel US and an US score in predicting disease course in UC. Milan ultrasound criteria, a validated US‐based score, predicts disease course in UC. Milan ultrasound criteria ≤ 6.2 may be the new treatment target to achieve to reduce the risk of worse outcomes.
Incidence and outcome of prenatal brain abnormality in twin‐to‐twin transfusion syndrome: systematic review and meta‐analysis
Authors: Sileo F. G. , Curado J. , D'Antonio F. , Benlioglu C. , Khalil A. 
Published: March 2022

ABSTRACTObjectivesTo evaluate the incidence of antenatally diagnosed brain injury in twin pregnancy complicated by twin‐to‐twin transfusion syndrome (TTTS) and to quantify the perinatal mortality, morbidity and long‐term neurodevelopmental outcome of these fetuses.MethodsMEDLINE, EMBASE,
ClinicalTrials.gov and The Cochrane Library databases were searched. Inclusion criteria were studies reporting on brain abnormality diagnosed antenatally in twin pregnancies complicated by TTTS. The primary outcome was the incidence of prenatal brain abnormality. The secondary outcomes were intrauterine demise (IUD), neonatal death, termination of pregnancy (TOP) and long‐term morbidity. Outcomes were explored in the population of fetuses with antenatal diagnosis of brain abnormality. Subgroup analysis according to the type of treatment, gestational age, Quintero stage at diagnosis and/or treatment, and cotwin death was planned. Meta‐analysis of proportions was used to combine data and pooled proportions and their 95% CI were reported.ResultsThirteen studies including 1573 cases of TTTS and 88 fetuses with an antenatal diagnosis of brain abnormality were included in the systematic review. The meta‐analysis included only studies reporting on brain abnormality in twin pregnancy complicated by TTTS cases and treated with laser surgery. Overall, brain injury occurred in 2.2% (52/2410) of fetuses (eight studies). Brain abnormality was reported in 1.03% and 0.82% of recipients and donors, respectively. The most common type of abnormality was ischemic lesions (30.4% (95% CI, 19.1–43.0%)), followed by destructive lesions (23.9% (95% CI, 13.7–35.9%)), ventriculomegaly (19.9% (95% CI, 10.6–31.3%)) and hemorrhagic lesions (15.3% (95% CI, 7.1–25.8%)). Spontaneous IUD occurred in 13.4% (95% CI, 5.1–24.8%) of fetuses, while TOP was chosen by parents in 53.5% (95% CI, 38.9–67.8%) cases. Neonatal death was reported by only three studies, with an incidence of 15.4% (95% CI, 2.8–35.4%). Finally, only two studies reported on composite morbidity, with an overall rate of the outcome of 20.4% (95% CI, 2.5–49.4%) and rates of 29.7% and 20.4% in the recipient and donor fetuses, respectively. Due to the small numbers, only composite morbidity was analyzed and no information on neonatal intensive care unit admission, respiratory distress syndrome or other long‐term outcomes, such as neurodevelopmental delay and cerebral palsy, could be retrieved reliably.ConclusionsThe overall incidence of antenatally diagnosed fetal brain abnormality in twin pregnancy complicated by TTTS treated with laser surgery is around 2% and is mainly ischemic in nature (30.4%). TOP was chosen by parents in more than half of cases (53.5%). No information could be retrieved on morbidity outcomes, highlighting the urgent need for long‐term follow‐up studies of these children. © 2022 International Society of Ultrasound in Obstetrics and Gynecology.
Examining subsurface response to an extreme precipitation event using HYDRUS‐1D
Authors: Corona Claudia R. , Ge Shemin 
Published: March 2022

AbstractNorth‐central Colorado experienced an extreme precipitation event (EPE) in September 2013, during which the equivalent of 80% of the region's annual average precipitation fell in a few days. Widespread flooding occurred above ground, but the short‐ and long‐term subsurface response remains unclear. The objective of the study is to better understand the dynamic subsurface response, namely how the water table and soil water storage responded to a large amount of infiltration in a short period of time and how the hydrologic properties of the subsurface influence the response. Better understanding of subsurface response to EPEs is expected to increase with the advent of more intense and frequent EPEs in the coming decades. A one‐dimensional subsurface flow model using HYDRUS‐1D, was built to simulate and examine infiltration of an EPE at a site in the Boulder Creek Watershed, Colorado. Model calibration was conducted with local field data to fit site observations over a 6‐yr period. A rapid water table depth response in field observations was observed, with the modeled subsurface storing water for 18 mo acting as a hydro‐buffer during recovery. To examine influence on model results, a sensitivity study of soil hydraulic parameters was conducted. The sensitivity study found that changes in n, an empirical parameter related to pore‐size distribution, most significantly affects water table depth. The implications are that one‐dimensional models may provide useful estimates of water table fluctuations and subsurface hydro‐buffer capacities in response to EPEs, which could be of use to regions preparing for EPE effect on water resources.
Introduction and Conceptual Framing—Transformation Literacy as a Future-Making Skill
Authors: Kuenkel Petra , Ragnarsdottir Kristin Vala 
Published: March 2022

AbstractThis chapter introduces the term transformation literacy as an urgently required skill for decision-makers and change agents. It suggests that transformation literacy is the knowledge and capacity of collectives of individual and institutional actors to steward sustainability transformations effectively together across institutions, societal sectors and nations. This includes the human capacity to collectively identify and shift dysfunctional patterns of societal and human-to-nature interaction at local and global scales. The chapter summarizes why transformation efforts are needed to not only achieve the vision of a sustainable world at all scales, but also to charter pathways towards regenerative civilizations. It briefly analyses the current failing systems and suggests that there is a need to build societal structures and institutional systems that have systems aliveness as its core value. It explores the role of future narratives of emergency, which currently dominate the discourse around the climate crisis, and narratives of emergence that are increasingly used in the niches of pioneering new approaches to regenerative civilizations. The chapter suggests to deepen knowledge and practice in the three levels of transformation literacy: mindset shifts, systems understandingand process competence. It concludes with an overview how these three levels of transformation literacy inform the three parts of the book.
Sustainable Community Transformation Process. The Role of Capacity Building in Sumba, Indonesia
Authors: Sulistyowati Catharina Any , Nurhasana Renny 
Published: March 2022

AbstractThis chapter is about the role of capacity building of local NGOs in Sumba, a poor island in the Eastern part of Indonesia. It is part of a larger initiative referred to as Sumba Iconic Island (SII), which aimed to solve poverty problems, transforming unequal gender relations while at the same time mitigating climate change. This study traced what happened after six years after the project ended. It is done by exploring the project documentation and conducting interviews with Hivos staff and the alumni representatives. We find that it has improved nature, community wellbeing, women leadership, and more equal gender relations. We conclude that: (1) transformation is not a linear process; (2) the changes toward the vision are not direct but tortuous; (3) there are unintended consequences, which can be positively or negatively influence the initial goal, and (4) the capacity to analyze the situation, reflect, and create action is crucial in the transformation process.
Toward Transformation to a Well-Being Economy in an African Country: A Case Study from Namibia
Authors: Braby Justine , Mangundu Reinhold 
Published: March 2022

AbstractIn this chapter presents the results of various approaches used by a group of young Namibians to shift the society toward a well-being economy. They sought to find more appropriate measurements of success, and did this by conducting (a) a survey to measure progress, (b) different dialog processes to understand what a good quality of life actually means to citizens, (c) co-constructing community well-being from the bottom up, (d) communication, networking, and awareness to garner public support, and finally (e) attempting to influence high-level decision-making in government. The authors measured nine domains; of which, state of mind and perceived health were the only domains found to be sufficient. The domains community strength and sense of belonging were the lowest in the high-income area. The domains with the highest levels of dissatisfaction were good governance and political freedom. The process of co-constructing community well-being through a bottom-up approach had varying levels of success and was highly adaptive and flexible. The key findings were that the underlying components of well-being were trust (at all levels), a sense of belonging and healthy relationships, basic needs (home, food, water, sanitation, electricity), quality education (the kind that causes critical and systems thinking and develops creative potential), quality work (that is demanding and rewarding), and good health.
Turning Mindshifts into Transformation Leadership
Authors: Bozesan Mariana 
Published: March 2022

AbstractThis chapter analyzes how mindshifts turn into transformation leadership. The COVID-19 pandemic has demonstrated humanity’s collective ability to provide solutions to a disruptive threat in record time. It is this mindset and political will that are required to address the much bigger, existential threats including nuclear, climate change, unsafe AI, and unethical social engineering that is assaulting democracy. After introducing Wilber’s integral theory as an underlying map of consciousness, the author discusses some hidden truths of the current consciousness crisis and maintains that any transformation literacy, individual or collective, must go beyond exterior aspects of the world out-there to include interior, mindshifting factors of the world in-here. The author shares research performed on consciousness leaders and emphasizes (1) the complexity of the human psyche including the circumstances that enable, facilitate, and accelerate societal polarization; (2) the underlying dynamics facilitating broken information ecologies; (3) the major aspects leading to individual and collective mindshifts; (4) how the human capacity can be enticed to cooperate toward addressing current existential threats; (5) how to uncover cognitive, emotional, moral, and other biases that twist our picture of reality; and (6) how to learn to separate the truth signals from the fake noise.
Red Snow—When the Climate Bleeds: A Nordic Art and Science Project Aimed at Overcoming Climate Apathy Through Collaboration Between Artists and Scientists
Authors: Endresen Bente Elisabeth 
Published: March 2022

AbstractThis chapter describes the transformative potential of arts and science collaboration. The aim of the Nordic art and science project “Red Snow—When the Climate Bleeds” which was undertaken in 2014–2016 was to increase people's awareness of the accelerating climate changes we are witnessing in the twenty-first century. This chapter shows how people can be encouraged to take action for the care of our planet and to live in a more sustainable way. The project was centred around an exhibition, consisting of artwork and scientific presentations, established collaboration with students at schools and universities and was implemented in four countries. In order to highlight the urgency of the need for change, the project showed some future scenarios presented by climate researchers. With the use of visual art, music and dance, it was possible to reach a larger audience than science alone could: this opened people's hearts and minds to new knowledge. The chapter concludes that the collaboration between the arts and science is increasingly important. Art can successfully go beyond the mental mindset, and speak directly to the emotions of the audience, and once works of art have made an impression, visitors are generally more open to new knowledge.
Setting the Scene: How to Connect with a World as an Interconnected Whole
Authors: Kuenkel Petra 
Published: March 2022

AbstractThis chapter offers a conceptual deep dive into the complex field of mindset shifts as prerequisite for regenerative civilizations and a driver of transformations. The chapter explores why a global shift in mindsets is a necessary condition for accelerating proactive and collective behaviour change, and how this could happen. It suggests that mindsets are both place-based and global. They emerge from culture and traditions and are at the same time heavily influenced by global exchange and communication. The stories about how the world works, how reality emerges and how people can co-create futures give rise to narratives of possibilities—the key leverage points for transformation literacy. The chapter identifies three noticeable trends which have implications for transformation literacy. The first trend is a deeper understanding of co-evolution which refers to the world’s complex relationality in dynamic co-evolutionary patterns. The second trend is the emerging theme of a relational quality of life that refers to the interaction of social, political and natural systems. The third trend is the emerging realization of the need for stewardship referring to a caring role in future-making. The chapter concludes with an overview of the different authors’ chapters and how they relate to the emerging trends.
Memories of Our Collective Future
Authors: Nnoli-Edozien Ndidi 
Published: March 2022

AbstractThis chapter explores the mindset humanity needs to develop in preparation for an emerging future, from an African perspective. The required human consciousness must be holistic and encompassing, bridging the gap between thought and action, linking the past to the present and the future, democratizing access to resources, eliminating waste and fostering regeneration. One opportunity in view is leveraging the power of emerging twenty-first-century technology, specifically blockchain-based decentralized financial (De-Fi) networks, because of their potential to build a global community where trust is once more a currency and where we can rely on humanity to do good for each other and for the planet. We need to design solutions and approaches that enable all persons, especially those marginalized in emerging economies, to find their voices and fulfil their aspirations. The author makes a strong case for combining past wisdom with contemporary know-how to create a new future that is more inclusive and equitable. Drawing on African traditional philosophy and practices, learning from Ubuntu and the Igbo people, she explores the balance between individual rights and communal values. The chapter also offers insights into the SevenPillars® framework that allows business interests, private and public, to thrive whilst safeguarding our natural ecosystem and upholding human dignity and equity.