bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultra‐Robust and Extensible Fibrous Mechanical Sensors for Wearable Smart Healthcare
Authors: Gao Jiuwei , Fan Yubo , Zhang Qingtian , Luo Lei , Hu Xiaoqi , Li Yue , Song Juncai , Jiang Hanjun , Gao Xiaoyu , Zheng Lu , Zhao Wu , Wang Zhenhua , Ai Wei , Wei Yuan , Lu Qianbo , Xu Manzhang , Wang Yongtian , Song Weitao , Wang Xuewen , Huang Wei 
Published: March 2022

AbstractFibrous material with high strength and large stretchability is an essential component of high‐performance wearable electronic devices. Wearable electronic systems require a material that is strong to ensure durability and stability, and a wide range of strain to expand their applications. However, it is still challenging to manufacture fibrous materials with simultaneously high mechanical strength and the tensile property. Herein, the ultra‐robust (≈17.6 MPa) and extensible (≈700%) conducting microfibers are developed and demonstrated their applications in fabricating fibrous mechanical sensors. The mechanical sensor shows high sensitivity in detecting strains that have high strain resolution and a large detection range (from 0.0075% to 400%) simultaneously. Moreover, low frequency vibrations between 0 and 40 Hz are also detected, which covers most tremors that occur in the human body. As a further step, a wearable and smart health‐monitoring system has been developed using the fibrous mechanical sensor, which is capable of monitoring health‐related physiological signals, including muscle movement, body tremor, wrist pulse, respiration, gesture, and six body postures to predict and diagnose diseases, which will promote the wearable telemedicine technology.
A Vinylene‐Linker‐Based Polymer Acceptor Featuring a Coplanar and Rigid Molecular Conformation Enables High‐Performance All‐Polymer Solar Cells with Over 17% Efficiency
Authors: Yu Han , Wang Yan , Kim Ha Kyung , Wu Xin , Li Yuhao , Yao Zefan , Pan Mingao , Zou Xinhui , Zhang Jianquan , Chen Shangshang , Zhao Dahui , Huang Fei , Lu Xinhui , Zhu Zonglong , Yan He 
Published: March 2022

AbstractState‐of‐art Y‐series polymer acceptors are typically based on a mono‐thiophene linker, which can cause some twisted molecular conformations and thus limit the performance of all‐polymer solar cells (all‐PSCs). Here, a high‐performance polymer acceptor based on vinylene linkers is reported, which leads to surprising changes in the polymers’ molecular conformations, optoelectronic properties, and enhanced photovoltaic performance. It is found that the polymer acceptors based on thiophene or bithiophene linkers (PY‐T‐γ and PY‐2T‐γ) display significant molecular twisting between end‐groups and linker units, while the vinylene‐based polymer (PY‐V‐γ) exhibits a more coplanar and rigid molecular conformation. As a result, PY‐V‐γ demonstrates a better conjugation and tighter interchain stacking, which results in higher mobility and a reduced energetic disorder. Furthermore, detailed morphology investigations reveal that the PY‐V‐γ‐based blend exhibits high domain purity and thus a better fill factor in its all‐PSCs. With these, a higher efficiency of 17.1% is achieved in PY‐V‐γ‐based all‐PSCs, which is the highest efficiency reported for binary all‐PSCs to date. This work demonstrates that the vinylene‐linker is a superior unit to build polymer acceptors with more coplanar and rigid chain conformation, which is beneficial for polymer aggregation and efficient all‐PSCs.
Process‐Aid Solid Engineering Triggers Delicately Modulation of Y‐Series Non‐Fullerene Acceptor for Efficient Organic Solar Cells
Authors: Song Xin , Zhang Kai , Guo Renjun , Sun Kun , Zhou Zhongxin , Huang Shenglei , Huber Linus , Reus Manuel , Zhou Jungui , Schwartzkopf Matthias , Roth Stephan V. , Liu Wenzhu , Liu Yu , Zhu Weiguo , Müller‐Buschbaum Peter 
Published: March 2022

AbstractVolatile solids with symmetric π‐backbone are intensively implemented on manipulating the nanomorphology for improving the operability and stability of organic solar cells. However, due to the isotropic stacking, the announced solids with symmetric geometry cannot modify the microscopic phase separation and component distribution collaboratively, which will constrain the promotion of exciton splitting and charge collection efficiency. Inspired by the superiorities of asymmetric configuration, a novel process‐aid solid (PAS) engineering is proposed. By coupling with BTP core unit in Y‐series molecule, an asymmetric, volatile 1,3‐dibromo‐5‐chlorobenzene solid can induce the anisotropic dipole direction, elevated dipole moment, and interlaminar interaction spontaneously. Due to the synergetic effects on the favorable phase separation and desired component distribution, the PAS‐treated devices feature the evident improvement of exciton splitting, charge transport, and collection, accompanied by the suppressed trap‐assisted recombination. Consequently, an impressive fill factor of 80.2% with maximum power conversion efficiency (PCE) of 18.5% in the PAS‐treated device is achieved. More strikingly, the PAS‐treated devices demonstrate a promising thickness‐tolerance character, where a record PCE of 17.0% is yielded in PAS devices with a 300 nm thickness photoactive layer, which represents the highest PCE for thick‐film organic solar cells.
Highly Effective Stroke Therapy Enabled by Genetically Engineered Viral Nanofibers
Authors: Liu Xiangyu , Yang Mei , Lei Fang , Wang Yaru , Yang Mingying , Mao Chuanbin 
Published: March 2022

AbstractStroke results in the formation of a cavity in the infarcted brain tissue. Angiogenesis and neurogenesis are poor in the cavity, preventing brain‐tissue regeneration for stroke therapy. To regenerate brain tissue in the cavity, filamentous phages, the human‐safe nanofiber‐like bacteria‐specific viruses, are genetically engineered to display many copies of RGD peptide on the sidewalls. The viral nanofibers, electrostatically coated on biocompatible injectable silk protein microparticles, not only promote adhesion, proliferation, and infiltration of neural stem cells (NSCs), but also induce NSCs to differentiate preferentially into neurons in basal medium within 3 d. After the NSC‐loaded microparticles are injected into the stroke cavity of rat models, the phage nanofibers on the microparticles stimulate angiogenesis and neurogenesis in the stroke sites within two weeks for brain regeneration, leading to functional recovery of limb motor control of rats within 12 weeks. The viral nanofibers also brought about the desired outcomes for stroke therapy, such as reducing inflammatory response, decreasing thickness of astrocytes scars, and increasing neuroblasts response in the subventricular zone. As virtually any functional peptide can be displayed on the phage by genetic means, the phage nanofibers hold promise as a unique and effective injectable biomaterial for stroke therapy.
Biomass‐Derived Crocodile Skin‐Like Porous Carbon for High‐Performance Microwave Absorption
Authors: Wu Zhihong , Yao Cheng , Meng Zhenzhen , Deng Yue , Wang Yao , Liu Jiayuan , Wang Yubin , Zhou Huafeng 
Published: March 2022

AbstractBiomass‐derived porous carbon materials have received extensive attention in electromagnetic wave absorbing (EMA) materials due to their stability, lightweight, and friendliness. Adjusting the morphology of porous carbon materials is an effective way to improve their absorbing properties. In this work, the crocodile skin‐like biomass hierarchical porous carbon (BHPC) material was synthesized from waste rice husk via a carbonization and alkali activation process. The effect of the consistency of the activator on the porous morphology is investigated. Under ultra‐low filler content of 10 wt%, the minimum reflection loss (RLmin) of the BHPC‐10 composite material reaches −47.46 dB, and the effective absorption bandwidth (EAB) is up to 3.40 GHz in the X‐band at a thickness of 2.8 mm. This work provides a reference for preparing porous carbon materials derived from pure biomass and a feasible scheme for designing high‐performance microwave absorbing materials.
High‐Performance, Flexible NO2 Chemiresistors Achieved by Design of Imine‐Incorporated n‐Type Conjugated Polymers
Authors: Park Hyeonjung , Kim Dong‐Ha , Ma Boo Soo , Shin Euichul , Kim Youngkwon , Kim Taek‐Soo , Kim Felix Sunjoo , Kim Il‐Doo , Kim Bumjoon J. 
Published: March 2022

AbstractFlexible and mechanically robust gas sensors are the key technologies for wearable and implantable electronics. Herein, the authors demonstrate the high‐performance, flexible nitrogen dioxide (NO2) chemiresistors using a series of n‐type conjugated polymers (CPs: PNDIT2/IM‐x) and a polymer dopant (poly(ethyleneimine), PEI). Imine double bonds (C = N) are incorporated into the backbones of the CPs with different imine contents (x) to facilitate strong and selective interactions with NO2. The PEI provides doping stability, enhanced electrical conductivity, and flexibility. As a result, the NO2 sensors with PNDIT2/IM‐0.1 and PEI (1:1 by weight ratio) exhibit outstanding sensing performances, such as excellent sensitivity (ΔR/Rb = 240% @ 1 ppm), ultralow detection limit (0.1 ppm), high selectivity (ΔR/Rb < 8% @ 1 ppm of interfering analytes), and high stability, thereby outperforming other state‐of‐the‐art CP‐based chemiresistors. Furthermore, the thin film of PNDIT2/IM‐0.1 and PEI blend is stretchable and mechanically robust, providing excellent flexibility to the NO2 sensors. Our study contributes to the rational design of high‐performance flexible gas sensors.
Realizing Fast Synthesis of High‐Silica Zeolite Y with Remarkable Catalytic Performance
Authors: Zhu Dali , Wang Linying , Zhang Wenna , Fan Dong , Li Jinzhe , Cui Wenhao , Huang Shengjun , Xu Shutao , Tian Peng , Liu Zhongmin 
Published: March 2022

AbstractHigh‐silica zeolite Y (FAU) plays a vital role in (petro)chemical industries. However, the slow nucleation and growth kinetics of the high‐silica FAU framework limit its direct synthesis and the improvement of framework SiO2/Al2O3 ratio (SAR). Here, a facile strategy is developed to realize the fast crystallization of high‐silica zeolite Y, which involves the combination of high crystallization temperature, ultra‐stable Y (USY) seeds and efficient organic‐structure directing agent (OSDA). The synthesis can be finished in 5–16 h at 160 °C and with tunable SAR up to 18.2, and the key factors affecting crystallization kinetics and phase purity are elucidated. Moreover, the crystallization process was monitored to reveal the fast crystal growth mechanism. The high‐silica products possess high (hydro)thermal stability and abundant strong acid sites, which endow them excellent catalytic cracking performance, obviously superior to commercial USY.
Influence of organic additives with electron‐withdrawing and electron‐donating groups on insulation properties of cross‐linked polyethylene at high temperatures for HVDC cable applications
Authors: Shi Yiwen , Chen Xiangrong , Meng Fan‐Bo , Awais Muhammad , Hong Zelin , Paramane Ashish , Li Hao 
Published: March 2022

AbstractThis paper investigated the influence of three aromatic voltage stabilizers (4‐n‐propylbenzoic acid, 2‐methoxyphenylboronic acid, and 3‐aminobenzoylmethylamide) on insulating properties of cross‐linked polyethylene (XLPE) at high temperatures for high voltage direct current (HVDC) applications. The XLPE blends containing 1 wt% voltage stabilizers were prepared through a solution‐blending method. The addition of voltage stabilizers suppressed the space charge inside the XLPE at high temperatures. The DC conductivity of XLPE and its blends increased with temperature. The DC conductivity of the XLPE blended with the 4‐n‐propylbenzoic acid was lowest at the different temperatures and electric fields. The DC breakdown strength of the tested materials continually decreased as the temperature increased. Notably, the DC breakdown strength of XLPE with the addition of 4‐n‐propylbenzoic acid and 3‐aminobenzoylmethylamide was higher than the reference XLPE at high temperatures. Moreover, the thermal stability of the XLPE remained unaffected after the voltage stabilizer's addition, whereas the thermal conductivity was improved. Quantum chemical calculations showed that the addition of voltage stabilizers with lower LUMO could effectively buffer the high‐energy electrons and improve the DC breakdown strength of the XLPE. A buffering mechanism of high‐energy electrons demonstrated the effect of the voltage stabilizers on the DC breakdown strength in the XLPE.
Culture and dreaming: A story of co‐creation
Authors: Fisher Charles P. 
Published: March 2022

AbstractWe are haunted by “ghosts” derived from the cultural history in which we are immersed. Many of these ghosts are deeply unconscious in a psychodynamic sense―repressed, disavowed, or denied. Experiences of triangulation, via prolonged emotional exposure to a different culture, may assist in gaining awareness of the presence of these ghosts. Cultural beliefs such as the nature of reality, causality, and time are fundamental for the developing child. These beliefs develop in a child through the very earliest identifications with primary caretakers. Hence, they form the fabric of reality for the child. Loewald makes a very similar point about the development of reality sense. Evidence for the child's primary identification with the mother as subject is presented in Trigant Burrow's writing nearly a century ago, and in contemporary writing about gender development in women and in men. Further support for the very early role of culture in promoting “learning from experience” is provided by Mark Solms who demonstrates the crucial role of “precision”―that is, the ability to assess the significance of each perception. Studies of the relationship between dream reality and waking reality for an indigenous people in the Amazon rainforest show that the very fabric of reality depends upon culture. In this paper, the author discusses ghosts from his own childhood and from recent American cultural history. As a Jewish child in America, he absorbed resonances of Eastern European pogroms, Holocaust history, and ancient Jewish slavery in Egypt, commemorated in the Passover Seder. As an American boy, he grew up with the legacies of racism, the enslavement of African–Americans, and genocidal attacks on indigenous peoples. These ghosts (and others) were simultaneously displayed, hidden in plain sight, and deeply repressed in cultural artifacts such as Edward Steichen's Family of Man photographic exhibition. Discussion of that exhibition illustrates the multiple ways that culture is constitutive of conscious, preconscious, and deeply unconscious mental life. In a variety of ways, psychoanalysis both helps and hinders exploration of cultural influences. To shed light on what is culturally repressed, and to triangulate the culture one grows up in, it's helpful to live in another culture for a while. Experiences with the Achuar people in the Amazon rainforest provide a lens for examining culture, reality, and dreaming.
Exciton–tryptophan coupling pulse behaviour along with corona formation, binding analysis, and interaction study of ZnO nanorod–serum albumin protein bioconjugate
Authors: Kumar Bhunia Amit , Jha Pradeep K. , Saha Satyajit 
Published: March 2022

AbstractThe bioconjugate of bovine serum albumin (BSA) and zinc oxide nanorods (ZnO NRs) is investigated to explore the behaviour of the tryptophan (Trp)–exciton coupling and corona formation. The pulse like nature of the coupled system between Trp of BSA and exciton of ZnO NRs has been observed after analysis of the optical parameters such as refractive index, susceptibility, and optical dielectric constant. The time constant for tryptophan, exciton surface binding (t1) and reorganization (t2) are found to be (t1) 8 min, 7 min and (t2) 150 min, 114.5 min, respectively. The close proximity binding of BSA with ZnO NRs via tryptophan as well as exciton is responsible for bioconjugate formation. The aggregated structure of BSA is observed from small‐angle X‐ray scattering study in interaction with ZnO NRs. The change in secondary structure and tertiary deformation of the serum protein have been studied from Fourier transform infrared and emission quenching analyses. The number of binding sites (n) signified to the enhancement of the cooperative binding. The binding has been found to be endothermic and favoured using unfavourable positive enthalpy with a favourable entropy change from the result of the isothermal titration calorimetry.
Colorectal cancer screening preferences among physicians and individuals at average risk: A discrete choice experiment
Authors: Heidenreich Sebastian , Finney Rutten Lila J. , Miller‐Wilson Lesley‐Ann , Jimenez‐Moreno Cecilia , Chua Gin Nie , Fisher Deborah A. 
Published: March 2022

AbstractBackgroundGuidelines include several options for average‐risk colorectal cancer (CRC) screening that vary in aspects such as invasiveness, recommended frequency, and precision. Thus, patient and provider preferences can help identify an appropriate screening strategy. This study elicited CRC screening preferences of physicians and individuals at average risk for CRC (IAR).MethodsIAR aged 45–75 years and licensed physicians (primary care or gastroenterology) completed an online discrete choice experiment (DCE). Participants were recruited from representative access panels in the US. Within the DCE, participants traded off preferences between screening type, screening frequency, true‐positive, true‐negative, and adenoma true positive (physicians only). A mixed logit model was used to obtain predicted choice probabilities for colonoscopy, multi‐target stool DNA (mt‐sDNA), fecal immunochemical test (FIT), and methylated septin 9 (mSEPT9) blood test.ResultsPreferences of IAR and physicians were affected by screening precision and screening type. IAR also valued more regular screening. Physicians preferred colonoscopy (96.8%) over mt‐sDNA (2.8%; p < 0.001), FIT (0.3%; p < 0.001) and mSEPT9 blood test (0.1%; p < 0.01). IAR preferred mt‐sDNA (38.8%) over colonoscopy (32.5%; p < 0.001), FIT (19.2%; p < 0.001), and mSEPT9 blood test (9.4%; p < 0.001). IAR naïve to screening preferred non‐invasive screening (p < 0.001), while the opposite was found for those who previously underwent colonoscopy or sigmoidoscopy.ConclusionsWhile physicians overwhelmingly preferred colonoscopy, preferences of IAR were heterogenous, with mt‐sDNA being most frequently preferred on average. Offering choices in addition to colonoscopy could improve CRC screening uptake among IAR.This study used a discrete choice experiment in the US to elicit preferences of physicians and individuals at average risk for colorectal cancer screening modalities and their characteristics.
Allosteric Probe Recognition Initiated Cascade Transcription Amplification for Sensitive Analysis of Exosomes
Authors: Lei Huabin , Ma Yaru , Zhang Hui , Cao Zenghui , Zhang Heng 
Published: March 2022

AbstractSensitive and accurate analysis of exosomes is important for many biological processes including as a biomarker for cerebral venous thrombosis (CVT) diagnosis and therapy. Herein, we established a sensitive and specific exosome detection approach based on target recognition initiated cascade signal amplification. In this method, an allosteric probe was designed with a hairpin structure for specific recognition of the exosome followed by signal amplification. After the cascade signal amplification process, spinach RNA sequences bind to DFHBI ((Z)‐4‐(3,5‐difluoro‐4‐hydroxybenzylidene)‐1,2‐dimethyl‐1H‐imidazol‐5(4H)‐one) to produce enhanced fluorescence signal (approximate 2000 fold than that of inactive DFHBI). Compared with former proposed exosome detection techniques, this method exhibited a comparable detection range, but with an easy‐to‐design toolbox. Therefore, we believe that the proposed approach holds great potential for exosome based early diagnosis and prognosis of disease.
Rapid Advances of Versatile MXenes for Electrochemical Enzyme‐Based Biosensors, Immunosensors, and Nucleic Acid‐Based Biosensors
Authors: Yao Bo , Yao Jiantao , Fan Zhenqiang , Zhao Jianfeng , Zhang Kai , Huang Wei 
Published: March 2022

AbstractElectrochemical biosensors have played an important role in clinical diagnostics, drug analysis, environmental monitoring, food safety, and other fields. Versatile two‐dimensional (2D) MXenes‐based nanomaterials, born with intrinsic peculiarities including high electrical conductivity, low toxicity, large specific surface area, and good biocompatibility, provide sufficient potential candidates for the construction of universal or specific electrochemical biosensors. In this review, we summarized the latest advances in 2D MXenes nanomaterials for constructing electrochemical enzyme‐based biosensors, immunosensors, and nucleic acid‐based biosensors in 2021, and then discussed the pertinent roles of corresponding 2D MXenes and carried out a comparison of the difference in the detection limit and detection range. Finally, challenges and future prospects of 2D MXenes‐based electrochemical biosensors are proposed and discussed.
SOLEDGE3X full vessel plasma simulations for computation of ITER first‐wall fluxes
Authors: Rivals Nicolas , Tamain Patrick , Marandet Yannick , Bonnin Xavier , Bufferand Hugo , Pitts Richard A. , Falchetto Gloria , Yang Hao , Ciraolo Guido 
Published: March 2022

AbstractITER Pre‐Fusion Power Operation 1 (PFPO‐1) phase low‐power plasmas are simulated with the SOLEDGE3X‐EIRENE code, a multi‐fluid edge plasma solver that can describe plasma conditions up to the machine's first wall, including a kinetic description of neutrals. Here, SOLEDGE3X is used in 2D mean‐field mode. A throughput scan is performed, reproducing a similar scan from the ITER SOLPS simulations database. The physics assumptions for these simulations are presented, in particular the plasma–neutral interaction model where molecule charge‐exchange and ion‐molecule elastic collisions have newly been added. Challenges encountered in such up‐to‐the‐wall simulations are discussed, along with remaining open questions. Results are presented with two foci: on targets, and on the rest of the first wall. On targets, conditions transition from attached to partially detached as expected, and toroidally symmetric heat fluxes (i.e. without 3D effects) remain below 5 MW/m2, within the divertor design limits. An increase in the parallel heat flux decay length λq with throughput is also observed. On the rest of the first wall, increasing puff rate does not only spread power deposited on the target but also increases heat load on the first wall. These fluxes remain however small (<100 kW/m2).
Repurposing of digoxin in pain and inflammation: An evidence‐based study
Authors: Patel Saraswati , Gururani Ritika , Jain Smita , Tripathi Neetika , Paliwal Swati , Paliwal Sarvesh , Paliwal Shailendra , Sharma Swapnil 
Published: March 2022

AbstractIn recent years, the drug repositioning strategy has gained considerable attention in the drug discovery process that involves establishing new therapeutic uses of already known drugs. In line with this, we have identified digoxin a cardiac glycoside, as a potent inhibitor of soluble epoxide hydrolase (sEH) enzyme employing in silico high throughput screening protocols and further confirmed using in vitro cell‐free sEH inhibitory assay and in vivo preclinical studies in rodents for its repurposing in hyperalgesia, inflammation, and related disorders. Oral administration of digoxin at dose 0.2 mg/kg significantly reduced (p < .0001) the allodynia in mice induced by using hot plate (3.6 ± 1.9) and tail‐flick test (7.58 ± 0.9). In addition, digoxin at a dose of 0.2 mg/kg showed marked reduction (94%, p < .0001) in acetic acid‐induced abdominal contraction in rats. Further, digoxin also demonstrated antipyretic activity (37.04 ± 0.2, p < .0001) and showed notable reduction (0.60 ± 0.06) in carrageenan‐induced paw edema in rats. Also, the histopathological evaluation revealed that digoxin treatment attenuated the edema, neutrophil infiltration, and alveolar septal thickening in lung tissue. These findings are novel and highlight the newer insights towards repurposing digoxin as a new lead in the treatment of hyperalgesia, inflammation, and related disorders.