bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of spironolactone therapy on the activity of the matrix metalloproteinase system in patients with heart failure after COVID-19
Authors: Podzolkov V. I. , Tarzimanova A. I. , Bragina A. E. , Shvedov I. I. , Bykova E. E. , Ivannikov А. A. , Khanakyan S. S. , Almyasheva A. M. 
Published: November 2022

Aim. To assess the change in the activity of the matrix metalloproteinase (MMP) system after 6-month spironolactone therapy in patients with heart failure (HF) with preserved (HFpEF) and mildly reduced ejection fraction (HFmrEF) after coronavirus disease 2019 (COVID-19).Material and methods. The study included 90 patients treated at the University Clinical Hospital № 4 of the I.M. Sechenov First Moscow State Medical University with a laboratory-confirmed COVID-19. There were following inclusion criteria: age of 18-85 years; the presence of HFpEF and HFmrEF. The patients were randomized into two groups: group I (n=60) — patients with 6-month spironolactone therapy (25 mg/day) in addition to the standard therapy for HF, spironolactone was taken at a dose of 25 mg/day; Group II (comparison group, n=30) — patients who received standard therapy without spironolactone. All patients were determined plasma MMP concentrations.Results. There were no significant differences in the levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) between the groups when included in the study. A repeated investigation revealed a significant decrease in the concentrations of MMP-9 and TIMP-1 only in group I. In patients of group II, there were no significant changes in the plasma concentrations of MMP-9 and TIMP-1. The MMP-9/TIMP-1 ratio during the initial examination of patients did not have significant differences. After 6-months therapy, a significant decrease in the ratio of MMP-9/TIMP-1 was observed only in patients taking spironolactone.Conclusion. The results obtained confirm a significant decrease in MMP system activity after 6-month spironolactone therapy in patients with HFpEF and HFmrEF after COVID-19. The described antifibrotic effects of spironolactone make it possible to recommend the use of this drug in this category of patients to reduce the negative effect of MMPs on cardiovascular system.
Actions aimed at reducing, reusing and recycling waste in the construction of buildings
Authors: Mata de Oliveira Jaqueline , Lordsleem Júnior Alberto Casado , De Gois Santos Débora 
Published: November 2022

Being responsible for the generation of more than 50% of urban solid waste poses incessant challenges to the construction industry. Commonly called rubble, civil construction waste (RCC) causes major environmental impacts when an order of priority of actions in forwarding the management of discarded materials is not observed. It is a situation that requires the application of practices that aim to reduce, reuse and recycle (3R's) the waste generated by civil construction at construction sites. This work aims to present good practice guidelines, through an action plan, for the reduction, reuse and recycling of RCC in construction sites. The methodology included a systematic review of scientific articles considering the indications of the PRISMA method (Preferred Reporting Items for Systematic reviews and Meta-Analyses). It also included a field research, with seven case studies, with five works located in the city of Recife and two works located in the city of Caruaru, both in the State of Pernambuco, in which we sought to investigate waste management in the works and the actions reduction, reuse and recycling carried out at construction sites. The results showed the identification of reduction actions applied to the management of services, materials and equipment used in the execution of works and good practices of reuse and recycling for the main construction materials, such as: concrete, wood, plastic, plaster and metal. The main contribution of this work was to identify and describe good practice guidelines for better management of civil construction waste in terms of the 3R's.

KEYWORDS: Reduction. reuse. Recycling.
Real-World Evidence on the Effectiveness of Plexiglass Barriers in Reducing Aerosol Exposure
Authors: Cadnum Jennifer , Jencson Annette , Memic Samir , Osborne Andrew , Torres-Teran Maria , Wilson Brigid , Deshpande Abhishek , Donskey Curtis 
Published: November 2022

Reprinted with permission, Cleveland Clinic Foundation ©2022. All Rights Reserved
Background: Barriers are commonly installed in workplace situations where physical distancing cannot be maintained to reduce the risk for transmission of respiratory viruses. Although some types of barriers have been shown to reduce exposure to aerosols in laboratory-based testing, limited information is available on the efficacy of barriers in real-world settings.
Methods: In an acute care hospital, we tested the effectiveness of in-use plexiglass barriers in reducing exposure of staff to aerosolized particles. A nebulizer was used to release 5% NaCl aerosol 1 meter from staff members with and without the barrier positioned between the point of aerosol release and the hospital staff. Particle counts on the staff side of the barrier were measured using a 6-channel particle counter. A condensed moisture (fog) generating device was used to visualize the airflow patterns.
Results: Of 13 in-use barriers tested, 6 (46%) significantly reduced aerosol particle counts detected behind the barrier, 6 (46%) reduced particle counts to a modest, non-significant degree, and 1 (8%) significantly increased particle counts behind the barrier. Condensed moisture fog accumulated in the area where staff were seated behind the barrier that increased particle exposure, but not behind the other barriers. After repositioning the ineffective barrier, the condensed moisture fog no longer accumulated behind the barrier and aerosol exposure was reduced.
Conclusion: In real-world settings, plexiglass barriers vary widely in effectiveness in reducing staff exposure to aerosols, and some barriers may increase risk for exposure if not positioned correctly. Devices that visualize airflow patterns may be useful as simple tools to assess barriers.
Use of learning media through technology for biology education students
Authors: Maulana Indra , Harahap Risma Delima , Safitri Islamiani 
Published: November 2022

Education is a learning process in increasing the knowledge and insights possessed by these students. The existence of technology for biology education students can be useful for the learning process and as a learning medium. This type of research is qualitative with descriptive method. The population used is the sixth semester of Biology Education Students, the total sample is 35 people, the data collection technique is done by giving questionnaires, the questionnaires are given to students directly and through google form. The results of the study obtained from 5 indicators (1) The use of learning media applications through the use of technology obtained a percentage of 60.29%, (2) Increased motivation obtained a percentage of 59.78%, (3) Effectiveness obtained a percentage of 61.30%, (4) Learning Media obtained the percentage of 56.36%, (5) Interest in Using Technology obtained a percentage of 57.96%, With the existence of learning media through the use of technology, it can support the implementation of learning for students and can get better knowledge insights.AbstrakPendidikan merupakan suatu proses pembelajaran didalam menambah pengetahuan wawasan yang dimiliki oleh mahasiswa tersebut. dengan adanya Teknologi bagi mahasiswa pendidikan biologi dapat bermanfaat untuk proses pembelajaran dan sebagai media pembelajaran Penelitian ini bertujuan untuk melihat dang mengetahui penggunaan media pembelajaran melalui pemanfaatan teknologi bagi mahasiswa pendidikan biologi memiliki peran penting didalam menunjang pelaksanaan pembelajaran. Jenis Penelitian ini kualitatif dengan metode deskriptif. Populasi yang digunakan adalah Mahasiswa/i Pendidikan Biologi Semester enam,Total sempel berjumlah 35 orang, Tehnik pengumpulan data dilakukan dengan pemberian angket, Angket tersebut diberikan kepada Mahasiswa/i yang secara langsung dan melalui google form. Hasil Penelitian yang diperoleh dari 5 indikator (1) Penggunaan Aplikasi media pembelajaran melalui pemanfaatan teknologi memperoleh persentase sebesar 60.29%, (2) Peningkatan Motivasi memperoleh persentase sebesar 59.78%, (3) Keefektifan memperoleh persentase sebesar 61.30%, (4) Media Pembelajaran memperoleh persentase sebesar 56.36%, (5) Minat Penggunaan Teknologi memperoleh persentase sebesar 57.96%, Dengan adanya media pembelajaran melalui pemanfaatan teknologi bisa menunjang didalam pelaksanaan pembelajaran bagi mahasiswa dan bisa mendapatkan wawasan pengetahuan yang lebih baik.
Improving student biology learning outcomes through guided inquiry assisted mind mapping
Authors: Hasanah Uswatun , Adlini Miza Nina 
Published: November 2022

Guided inquiry can make students active in solving problems with the skills and knowledge that students have. This supports the improvement of student learning outcomes and fosters student creativity in understanding learning materials through mind mapping. The purpose of this study was to examine the guided inquiry model with the aid of mind mapping on the biology learning outcomes of class X high school students. This type of research uses a quasi-experimental with Pre-test and Post-test Non Equivalent Control Group Design. The population of the study was class X students as many as 3 classes with a total of 108 people. The sample consisted of 2 classes, namely X IPA1 as the control class and X IPA2 as the experimental class. Samples were taken using purposive sampling technique. The data was taken using a test instrument in the form of multiple choice questions 20 questions. Data analysis was carried out using the t test, the results obtained were tcount> ttable so H0 was rejected and Ha was accepted. The conclusion of this study is that there is an effect of guided inquiry model with mind mapping on biology learning outcomes. This guided inquiry learning model with mind mapping can help students participate in the learning process and observation and can make students understand the subject matter better.Abstrak Inkuiri terbimbing dapat membuat siswa aktif dalam memecahkan masalah dengan keterampilan dan pengetahuan yang dimiliki siswa. Hal ini mendukung peningkatan hasil belajar siswa dan menumbuhkan kreatifitas siswa dalam memahami materi pembelajaran melalui mind mapping. Tujuan penelitian ini untuk melihat model inkuiri terbimbing berbantuan mind mapping terhadap hasil belajar biologi siswa kelas X SMA. Jenis penelitian menggunakan quasy experimental dengan Pre-test and Post-test Non Equivalent Control Group Design. Populasi dari penelitian adalah siswa kelas X sebanyak 3 kelas dengan jumlah 108 orang. Sampel terdiri atas 2 kelas yakni X IPA1 sebagai kelas kontrol dan X IPA2 sebagai kelas eksperimen. Sampel diambil menggunakan teknik purposive sampling. Data diambil menggunakan instrumen tes berupa soal pilihan berganda berjumlah 20 soal. Analisis data dilakukan dengan menggunakan uji t, diperoleh hasil thitung> ttabel jadi H0 ditolak dan Ha diterima. Kesimpulan dari penelitian ini adalah ada pengaruh model inkuiri terbimbing dengan mind mapping terhadap hasil belajar biologi. Model pembelajaran guided inquiry dengan mind mapping ini bisa membantu siswa berpartisipasi dalam proses pembelajaran maupun pengamatan serta dapat membuat siswa lebih memahami materi pelajaran.
Interactive Learning Media Development Articulate Storyline to Improve Science Literacy Capabilities of Junior High School Students
Authors: Kristiani Adela , Wahyuni Diah , Wahyuni Sri 
Published: November 2022

The purpose of the research was to determine the validity, practicality and effectiveness of interactive learning media based on Articulate Storyline on Global Warming Materials to improve the science literacy skills of junior high school students. The type of research uses development research with the model ADDIE. This research was conducted on class VII B students at one of the schools in the city of Probolinggo. This study used data collection techniques and instruments, including validation sheets, observation sheets of learning outcomes, tests, interviews and documentation. The results showed that interactive learning media based on Articulate Storyline is very valid with a percentage of 94.25%, very practical with a percentage of 92%, quite effective with an N-gain of 0.52 and a percentage of student response of 85%. So, interactive learning media based on Articulate Storyline on Global Warming Materials can be very feasible to use in science learning to improve the science literacy skills of junior high school students.
HUBUNGAN USIA, JENIS KELAMIN DAN ELEMEN GIGI DENGAN ANGKA KEJADIAN LESI PERIAPIKAL
Authors: Azzuhdi Muhammad Luthfi , Erlita Isyana , Azizah Aulia 
Published: November 2022

ABSTRACKBackground: Pulp necrosis is the final stage of pulpitis and is the beginning of periapical lesions. Periapical lesions that result from pulp necrosis are acute apical periodontitis, periapical abscess, and chronic apical periodontitis. Age and sex are related to the incidence number of periapical lesions where young people are more susceptible and behavior patterns in sex affect oral hygiene. Molar elements often occur periapical lesions because the molars have deep fit and fissure. Purposes: To determine the incidence number of periapical lesions. To determine the relationship between age and the incidence number of periapical lesions, the relationship between sex and the incidence number of periapical lesions and the relationship between dental elements and the incidence number of periapical lesions. Methods: This study used a descriptive analytic method with a cross-sectional design. The sample used is medical records. The number of samples is 86 with sampling using purposive sampling. Results: The results of the Kolmogorov-Smirnov test for the category of age (0.038<0.05), sex (0.993>0.05) and dental element (0.932>0,05). Conclusion: There is a relationship between age and the incidence number of periapical lesions, but there is no relationship between sex and dental elements and the incidence mumber of periapical lesions.Keywords: Age, dental elements, gender, periapical lesions, pulp necrosis.ABSTRAKLatar Belakang: Nekrosis pulpa merupakan tahap akhir dari pulpitis dan merupakan awal terjadinya lesi periapikal. Lesi periapikal yang terjadi akibat nekrosis pulpa adalah periodontitis apikalis akut, abses periapikal dan periodontitis apikalis kronis. Usia dan jenis kelamin berhubungan dengan angka kejadian lesi periapikal dimana usia muda lebih rentan dan pola perilaku pada jenis kelamin mempengaruhi oral hygiene. Elemen gigi molar sering terjadi lesi periapikal karena gigi molar memiliki fit and fissure yang dalam. Tujuan: Mengetahui angka kejadian lesi periapikal. Mengetahui hubungan antara usia dengan angka kejadian lesi periapikal, hubungan antara jenis kelamin dengan angka kejadian lesi periapikal dan hubungan antara elemen gigi dengan angka kejadian lesi periapikal. Metode: Penelitian ini menggunakan metode deskriptif analitik dengan desain cross-sectional. Sampel yang digunakan adalah rekam medik. Jumlah sampel sebanyak 86 dengan pengambilan sampel menggunakan purposive sampling. Hasil: Hasil uji Kolmogorov-smirnov untuk kategori usia (0.038<0.05), jenis kelamin (0.993>0.05) dan elemen gigi (0.932>0.05). Kesimpulan: Ada hubungan antara usia dengan angka kejadian lesi periapikal, tetapi tidak ada hubungan antara jenis kelamin dan elemen gigi dengan angka kejadian lesi periapikal. Kata kunci:Elemen gigi, jenis kelamin, lesi periapikal, nekrosis pulpa, usia.
HUBUNGAN PENGETAHUAN, SIKAP DAN TINDAKAN KESEHATAN GIGI DAN MULUT TERHADAP Oral Hygiene PADA SISWA SMP (Tinjauan Pada Siswa Kelas 1 di SMPN 1 Alalak Kabupaten Barito Kuala)
Authors: Aulia Devi Ayu , Hatta Isnur , Sari Galuh Dwinta 
Published: November 2022

ABSTRACTBackground: Dental and oral health problems experienced by people in Indonesia, especially in South Kalimantan, one of which is dental and oral hygiene caused by improper brushing behavior. A person's responsibility for oral and dental hygiene can be seen from the hygiene status of his teeth and mouth by looking at the OHI-S index will not be bad. Objectives: To analyze the relationship of knowledge, attitude and oral health action on oral hygiene in grade 1 students at SMPN 1 Alalak Barito Kuala. Method: This research is an analytical observational study with cross sectional design. Total amount of respondents are 32 students as respondents consisting of grade 1 students of SMPN 1 Alalak. Result: Spearman test showed that a relationship between knowledge, attitude and oral health action on oral hygiene. (p<0.05) in grade 1 students at SMPN 1 Alalak Barito Kuala. Conclusion: There is a meaningful relationship between knowledge, attitude and oral health action on oral hygiene in grade 1 students at SMPN 1 Alalak Barito Kuala. Keyword: Action, Attitudes, Knowledge, OHI-S Score Index, Oral Hygiene ABSTRAKLatar Belakang: Permasalahan kesehatan gigi dan mulut yang dialami oleh masyarakat di Indonesia terutama di Kalimantan Selatan salah satunya yaitu kebersihan gigi dan mulut yang disebabkan perilaku menyikat gigi yang tidak tepat. Tanggung jawab seseorang terhadap kebersihan gigi dan mulut terlihat dari status kebersihan gigi dan mulutnya dengan melihat indeks OHI-S tidak akan menjadi buruk. Tujuan: Menganalisis hubungan pengetahuan, sikap dan tindakan kesehatan gigi dan mulut terhadap oral hygiene pada siswa kelas 1 di SMPN 1 Alalak Kabupaten Barito Kuala. Metode: Menggunakan rancangan cross sectional dengan responden penelitian sebesar 32 siswa yang terdiri dari siswa kelas 1 SMPN 1 Alalak. Hasil: Uji korelasi spearman menunjukkan hubungan bermakna antara pengetahuan, sikap dan tindakan dengan oral hygiene (p<0,05) pada siswa kelas 1 di SMPN 1 Alalak Kabupaten Barito Kuala. Kesimpulan: Terdapat hubungan yang bermakna antara tingkat pengetahuan, sikap, dan tindakan kesehatan gigi dan mulut terhadap oral hygiene. Kata kunci: Indeks Skor OHI-S, Oral Hygiene, Pengetahuan, Sikap, Tindakan.
PENGARUH PAPARAN KOMBINASI KORTIKOSTEROID BUDESONIDE & FORMOTEROL TERHADAP PERUBAHAN KEKASARAN RESIN KOMPOSIT TIPE BULK-FILL
Authors: Biring Anugrah Amsal Pratama , Erlita Isyana , Setyawadhana R. Harry Dharmawan 
Published: November 2022

ABSTRACTBackground: Inhalation of asthma medication in the form of combination of the corticosteroid budesonide & formoterol which is acidic can affect the surface roughness of restoration materials such as composite resin. This is due to the significant change in the pH of saliva to 5.5 after 30 minutes of using an inhaler which can cause degradation of the polymer matrix composite resin and cause changes in surface roughness. Purpose: To determine the effect of exposure to the corticosteroid combination budesonide and formoterol on the roughness change of bulk-fill type composite resin. Methods: This study was true experimental research (pretest and post-test group design). The treatment group of bulk-fill type composite resin with exposure to a combination of budesonide & formoterol 160 / 4.5μg 2x1 inhalation; exposure to a combination of budesonide & formoterol 160 / 4.5μg 2x2 inhalation; without exposure to the combination budesonide & formoterol. The groups were tested using the Surface Roughness Tester. Results: One Way Anova and Post Hoc Bonferroni tests showed that there were significant differences between treatment groups (p<0.05).Conclusion: Exposure to a combination of budesonide and formoterol at a dose of 160 / 4.5μg 2x1inhalation and 2x2inhalation increased the roughness of bulk-fill type composite resin. Keywords: Bulk-fill type composite resin, combination of budesonide and formoterol, surface roughness. ABSTRAKLatar Belakang: Inhalasi obat asma yang berupa kombinasi kortikosteroid budesonide & formoterol yang bersifat asam dapat berpengaruh terhadap kekasaran permukaan bahan restorasi seperti resin komposit. Hal ini disebabkan terjadi perubahan yang signifikan pada pH saliva hingga berada di angka 5,5 setelah 30 menit menggunakan inhaler yang dapat menyebabkan terjadinya degradasi jaringan polimer matriks resin komposit dan menyebabkan perubahan kekasaran permukaan. Tujuan: Mengetahui pengaruh paparan kombinasi kortikosteroid budesonide dan formoterol terhadap perubahan kekasaran resin komposit tipe bulk-fill. Metode: Penelitian menggunakan metode eksperimental murni (pretest and post-test group design). Kelompok perlakuan resin komposit tipe bulk-fill dengan paparan kombinasi budesonide & formoterol 160/4,5μg 2x1 inhalasi; paparan kombinasi budesonide & formoterol 160/4,5μg 2x2 inhalasi; tanpa paparan kombinasi budesonide & formoterol. Ketiga kelompok diuji dengan alat Surface Roughness Tester. Hasil penelitian: Uji One Way Anova dan Post Hoc Bonferroni menunjukkan terdapat perbedaan yang bermakna antar kelompok perlakuan (p<0,05). Kesimpulan: Paparan kombinasi budesonide dan formoterol dosis 160/4,5μg 2x1 inhalasi dan 2x2 inhalasi meningkatkan kekasaran resin komposit tipe bulk-fill. Kata kunci: Kombinasi budesonide dan formoterol, kekasaran permukaan, Resin komposit bulk fill.
HUBUNGAN VISKOSITAS SALIVA DENGAN KEJADIAN KARIES GIGI PADA IBU HAMIL
Authors: Atqiya Nuril , Setyawardhana Raden Harry Dharmawan , Wardani Ika Kusuma 
Published: November 2022

ABSTRACTBackground: Women are more susceptible to dental caries, especially in pregnant women. The prevalence of dental caries during pregnancy in developed countries is found to be 41%-52%, while in developing countries it is 60%-87%. Pregnant women have higher risk of dental caries compared to women who are not pregnant. The risk of dental caries can be assessed through changing saliva on pregnant women. Saliva viscosity can assess the risk of dental caries because if saliva viscosity increases it will result in ineffective cleaning of the oral cavity. Objective: To analyze the relationship of saliva viscosity with the incidence of dental caries in pregnant women. Method: This research used literature review method with narrative review procedure. Literature searches are done using Google Scholar and PubMed. Result: There were 30 journals that fulfilled this study by 2013-2020, Indonesian and English journals, available in full-text form, journals with discussion of saliva viscosity in pregnant women and dental caries in pregnant women. Conclusion: There was a relationship between saliva viscosity and dental caries in pregnant women. Keywords: Dental caries, pregnant women, salivary viscosity ABSTRAKLatar Belakang: Perempuan lebih rentan terhadap karies gigi, khususnya pada ibu hamil. Angka prevalensi karies gigi pada masa kehamilan di negara maju ditemukan sebesar 41%-52%, sedangkan di negara berkembang sebesar 60%-87%. Ibu hamil memiliki risiko karies gigi yang lebih tinggi dibandingkan dengan wanita yang tidak hamil. Risiko karies gigi dapat dinilai melalui perubahan saliva ibu hamil. Viskositas saliva dapat menilai risiko dari karies gigi karena jika viskositas saliva meningkat akan mengakibatkan pembersihan rongga mulut menjadi tidak efektif. Tujuan: Menganalisis hubungan viskositas saliva dengan kejadian karies gigi pada ibu hamil. Metode: Penelitian ini menggunakan metode literature review dengan prosedur naratif review. Penelusuran literatur dilakukan menggunakan Google Scholar dan PubMed. Hasil: Terdapat 30 jurnal yang memenuhi penelitian ini dengan jurnal tahun 2013-2020, jurnal berbahasa Indonesia dan Inggris, tersedia dalam bentuk full-text, jurnal dengan pembahasan viskositas saliva pada ibu hamil dan karies gigi pada ibu hamil. Kesimpulan: Terdapat hubungan viskositas saliva dengan karies gigi pada ibu hamil. Kata kunci: Ibu hamil, karies gigi, viskositas saliva