bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination
Authors: Schwab Constantin , Domke Lisa Maria , Hartmann Laura , Stenzinger Albrecht , Longerich Thomas , Schirmacher Peter 
Published: November 2022

AbstractCases of myocarditis, diagnosed clinically by laboratory tests and imaging have been described in the context of mRNA-based anti-SARS-CoV-2 vaccination. Autopsy-based description of detailed histological features of vaccine-induced myocarditis is lacking. We describe the autopsy findings and common characteristics of myocarditis in untreated persons who received anti-SARS-CoV-2 vaccination. Standardized autopsies were performed on 25 persons who had died unexpectedly and within 20 days after anti-SARS-CoV-2 vaccination. In four patients who received a mRNA vaccination, we identified acute (epi-)myocarditis without detection of another significant disease or health constellation that may have caused an unexpected death. Histology showed patchy interstitial myocardial T-lymphocytic infiltration, predominantly of the CD4 positive subset, associated with mild myocyte damage. Overall, autopsy findings indicated death due to acute arrhythmogenic cardiac failure. Thus, myocarditis can be a potentially lethal complication following mRNA-based anti-SARS-CoV-2 vaccination. Our findings may aid in adequately diagnosing unclear cases after vaccination and in establishing a timely diagnosis in vivo, thus, providing the framework for adequate monitoring and early treatment of severe clinical cases.
Graphical abstract
Influence of fat-free mass index on the survival of patients with head and neck cancer
Authors: Lapornik Nina , Avramovič Brumen Brigita , Plavc Gaber , Strojan Primož , Rotovnik Kozjek Nada 
Published: November 2022

Abstract
Purpose
To determine whether muscle mass, defined by fat-free mass index (FFMI) measured with bioelectrical impedance analysis (BIA), is predictive of survival of head and neck squamous cell carcinoma (HNSCC) patients.

Methods
HNSCC patients treated between 2014 and 2018 at the Department for Nutrition of the Institute of Oncology Ljubljana were reviewed. The FFMI values from the pretreatment BIA measurements and pretreatment body mass index (BMI) were used to categorize patients into groups with low and normal muscle mass and BMI using the Global Leadership Initiative on malnutrition (GLIM) recommended cutoff values. The impact of FFMI on disease-free survival (DFS) and overall survival (OS) was determined.

Results
Of the 71 included patients, 31 (43.7%) had normal FFMI, and 40 (56.3%) had low FFMI, whereas 44 (62%) and 27 (38%) of the patients had normal and low BMI, respectively. Between FFMI and BMI values, a significant correlation was found (RP = 0.75, p < 0.001). Univariate regression analysis showed that FFMI (as a continuous variable) was of prognostic significance for OS (p = 0.039), which was confirmed by multivariate regression analysis (p = 0.029). The model where BMI replaced FFMI negated the prognostic value of BMI (as a continuous variable). Neither FFMI nor BMI was found to be a predictor of DFS on univariate or multivariate analysis.

Conclusions
In the present group of HNSCC patients, low FFMI adversely influenced OS, emphasizing the importance of using body composition measurement over BMI alone for pretreatment nutritional evaluation of these patients.
Association between lateral wall electrode array insertion parameters and audiological outcomes in bilateral cochlear implantation
Authors: Thimsen Vivian , Mantsopoulos Konstantinos , Liebscher Tim , Taha Lava , Eisenhut Felix , Iro Heinrich , Hoppe Ulrich , Hornung Joachim 
Published: November 2022

Abstract
Purpose
The aims of this study were to compare speech recognition at different postoperative times for both ears in bilaterally implanted patients and to assess the influence of the time of deafness, frequency-to-place mismatch, angular insertion depth (AID) and angular separation between neighbouring electrode contacts on audiometric outcomes.

Methods
This study was performed at an academic tertiary referral centre. A total of 19 adult patients (6 men, 13 women), who received sequential bilateral implantation with lateral wall electrode arrays, were analysed in retrospective. Statistical analysis was performed using two-sided t test, Wilcoxon test, median test, and Spearman’s correlation.

Results
Postlingually deafened patients (deafness after the age of 10) had a significantly better speech perception (WRS65[CI]) than the perilingually deafened subjects (deafness at the age of 1–10 years) (p < 0.001). Comparison of cochlear duct length between peri- and postlingually deafened subjects showed a slightly significantly smaller cochleae in perilingual patients (p = 0.045). No association between frequency-to-place mismatch as well as angular separation and speech perception could be detected. There was even no significant difference between the both ears in the intraindividual comparison, even if insertion parameters differed.

Conclusion
The exact electrode position seems to have less influence on the speech comprehension of CI patients than already established parameters as preoperative speech recognition or duration of deafness.
Onset and mortality of Parkinson’s disease in relation to type II diabetes
Authors: Pezzoli Gianni , Cereda Emanuele , Amami Paolo , Colosimo Santo , Barichella Michela , Sacilotto Giorgio , Zecchinelli Anna , Zini Michela , Ferri Valentina , Bolliri Carlotta , Calandrella Daniela , Bonelli Maria Grazia , Cereda Viviana , Reali Elisa , Caronni Serena , Cassani Erica , Canesi Margherita , del Sorbo Francesca , Soliveri Paola , Zecca Luigi , Klersy Catherine , Cilia Roberto , Isaias Ioannis U. 
Published: November 2022

Abstract
Objectives
There is growing evidence that Parkinson’s disease and diabetes are partially related diseases; however, the association between the two, and the impact of specific treatments, are still unclear. We evaluated the effect of T2D and antidiabetic treatment on age at PD onset and on all-cause mortality.

Research design and methods
The standardized rate of T2D was calculated for PD patients using the direct method and compared with subjects with essential tremor (ET) and the general Italian population. Age at onset and survival were also compared between patients without T2D (PD-noT2D), patients who developed T2D before PD onset (PD-preT2D) and patients who developed T2D after PD onset (PD-postT2D).

Results
We designed a retrospective and prospective study. The T2D standardized ratio of PD (N = 8380) and ET (N = 1032) patients was 3.8% and 6.1%, respectively, while in the Italian general population, the overall prevalence was 5.3%. In PD-preT2D patients, on antidiabetic treatment, the onset of PD was associated with a + 6.2 year delay (p < 0.001) while no difference was observed in PD-postT2D. Occurrence of T2D before PD onset negatively affected prognosis (adjusted hazard ratio = 1.64 [95% CI 1.33–2.02]; p < 0.001), while no effect on survival was found in PD-postT2D subjects (hazard ratio = 0.86, [95% CI 0.53–1.39]; p = 0.54).

Conclusions
T2D, treated with any antidiabetic therapy before PD, is associated with a delay in its onset. Duration of diabetes increases mortality in PD-preT2D, but not in PD-postT2D. These findings prompt further studies on antidiabetic drugs as a potential disease-modifying therapy for PD.
Test–retest reliability of a 30-min fixed perceived effort cycling exercise
Authors: O’Malley Callum A. , Fullerton Christopher L. , Mauger Alexis R. 
Published: November 2022

Abstract
Purpose

Using exercise protocols at a fixed rating of perceived effort (RPE) is a useful method for exploring the psychophysical influences on exercise performance. However, studies that have employed this protocol have arbitrarily selected RPE values without considering how these values correspond to exercise intensity thresholds and domains. Therefore, aligning RPE intensities with established physiological thresholds seems more appropriate, although the reliability of this method has not been assessed.

Methods

Eight recreationally active cyclists completed two identical ramped incremental trials on a cycle ergometer to identify gas exchange threshold (GET). A linear regression model plotted RPE responses during this test alongside gas parameters to establish an RPE corresponding to GET (RPEGET) and 15% above GET (RPE+15%GET). Participants then completed three trials at each intensity, in which performance, physiological, and psychological measures were averaged into 5-min time zone (TZ) intervals and 30-min ‘overall’ averages. Data were assessed for reliability using intraclass correlation coefficients (ICC) and accompanying standard error measurements (SEM), 95% confidence intervals, and coefficient of variations (CoV).

Results
All performance and gas parameters showed excellent levels of test–retest reliability (ICCs =  > .900) across both intensities. Performance, gas-related measures, and heart rate averaged over the entire 30-min exercise demonstrated good intra-individual reliability (CoV =  < 5%).

Conclusion
Recreationally active cyclists can reliably replicate fixed perceived effort exercise across multiple visits when RPE is aligned to physiological thresholds. Some evidence suggests that exercise at RPE+15%GET is more reliable than RPEGET.
COVID-19 related decline in cancer screenings most pronounced for elderly patients and women in Germany: a claims data analysis
Authors: Muschol Jennifer , Strauss Cornelia , Gissel Christian 
Published: November 2022

Abstract
Purpose
This study aimed to analyze the utilization of cancer screenings in Germany before and during the COVID-19 pandemic in 2020. The objective of the analysis was to identify the population at particular risk and to derive recommendations for the future use of resources to prevent long-term deteriorations in health outcomes.

Methods
The analysis was conducted based on claims data of all preventive health services for 15,833,662 patients from the largest statutory health insurance fund in Germany. Utilization of general female cancer screening, general male cancer screening, general health checkup, colorectal cancer screening stool test, colorectal cancer screening consultation, colonoscopy, skin cancer screening, and mammography screening was compared before (2017–2019) and during (2020) the pandemic.

Results
Data of a total of 42,046,078 observed screenings showed that the utilization of the individual screenings developed differently, but that the overall utilization decreased significantly by 21.46% during the COVID-19 pandemic (p < 0.001). At the same time, no catch-up effects were detected for total screenings throughout the entire year 2020. The highest decline in screenings was found for the elderly (p < 0.001) and women (p < 0.001).

Conclusion
Because the elderly are at higher risk for cancer, the omission of early detection might lead to higher treatment costs, reduced quality of life, and higher mortality. In addition, women's medical care in particular has been negatively affected, for example, by the interruption of mammography screenings and the lack of catch-up effects. Therefore, resources must be targeted to reduce burdens on health outcomes and public health in the long term.
Prostaglandin E2 receptor EP1 expression in vulvar cancer
Authors: Buchholz Anna , Vattai Aurelia , Fürst Sophie , Vilsmaier Theresa , Zati Zehni Alaleh , Steger Alexander , Kuhn Christina , Schmoeckel Elisa , Dannecker Christian , Mahner Sven , Jeschke Udo , Heidegger Helene H. 
Published: November 2022

Abstract
Purpose
In recent years, incidence of vulvar cancer has been on the rise, whereas therapeutic options are still restricted. Therefore, new prognosticators and therapeutic targets are essential. Chronic inflammation plays an important role in carcinogenesis and COX-2, and its product prostaglandin E2 and its receptors EP1–4 are known to be important mediators in cancer initiation and progression.

Methods
EP1 expression in vulvar cancer specimens (n = 129) was investigated via immunohistochemistry and evaluated using the well-established immunoreactive score (IRS). Subsequently, the values were correlated with clinicopathological parameters.

Results
Our analysis did not reveal EP1 expression as a negative prognostic factor in overall and disease-free survival. However, in the subgroup of patients with lymph-node metastasis, overall survival was significantly shorter in tumors with high EP1 expression. Moreover, EP1 expression correlated positively with good differentiation of the tumor, but not with p16 status or COX-2 expression.

Conclusions
This study shed first light on EP1 expression in vulvar carcinoma. EP1 expression correlated significantly with the grading of the tumor, suggesting that it influences cell differentiation. Further research on EP1 signaling may lead to a deeper understanding of the molecular mechanisms of carcinogenesis.
Continuous successive cycles of biosorption and desorption of acid red 27 dye using water hyacinth leaves as an effective, economic, and ecofriendly biosorbent
Authors: Ramírez-Rodríguez Allan Eduardo , Cristiani-Urbina Eliseo , Morales-Barrera Liliana , Aranda-García Erick 
Published: November 2022

AbstractWe investigated the capacity of water hyacinth leaves (LEC) to biosorb 75 mg/L acid red 27 (AR27) in a continuous system comprising 30 successive biosorption/desorption cycles in a packed-bed column at pH 2.0 and 56.5 L/m2·h volumetric flux. Using 0.025 M NaHCO3 eluent at 113 L/m2·h volumetric flux, all the dye was desorbed (100% desorption efficiency) from the loaded LEC biomass within 5–6 h. The same biosorbent was used for 147.5 consecutive days. The AR27 biosorption capacity, breakthrough time, and exhaustion time decreased from 69.4 to 34.5 mg/g, 74.81 to 14.1 h, and 101.1 to 34.1 h, respectively, and the critical bed height increased from 1.04 to 2.35 cm, as the number of biosorption/desorption cycles increased from 1 to 30. LEC life factor based on biosorption capacity predicted that the packed bed would be exhausted after 51.95 cycles. LEC is a promising biosorbent for bioremediation of AR27-laden wastewaters.
Contribution of intrusive and symplastic growths in wood fibre tip development
Authors: Miodek Adam , Gizińska Aldona , Kojs Paweł 
Published: November 2022

AbstractKey messageAt initial stages of fibre development, radial enlargement of growing fibre tip is achieved, on average, in 37.8% intrusively and in 62.2% symplastically, whereas tip tangential enlargement is purely intrusive.AbstractIn this study, we have investigated the mode of growth of black locust wood fibre tips at initial stages of their development using detailed measurements. Growth of fibre tips may be considered in three directions: axial, tangential, and radial. An axial elongation of a fibre tip was described as intrusive and related to the separation of walls of neighbouring cells. However, determination of the contribution of intrusive vs. symplastic component of growth in tangential and radial directions was missing. Semi-thin transverse sections of the vascular cambium and adjacent tissues were obtained by ultramicrotome and stained with PAS and toluidine blue. An anatomical analysis of contribution of intrusive and symplastic growths in fibre tip radial and tangential enlargement was performed. Our study showed that during its development an average wood fibre tip grows only intrusively in tangential direction and shows intrusive-symplastic growth in radial direction. On average, at initial stages of its development, a fibre tip radial enlargement is achieved in 37.8% by intrusive growth and in 62.2% by coordinated (symplastic) growth.
Comparison of hemodynamics and root configurations between remodeling and reimplantation methods for valve-sparing aortic root replacement: a pulsatile flow study
Authors: Seki Masahiro , Kunihara Takashi , Takada Jyunpei , Sasaki Kenichi , Kumazawa Ryo , Seki Hiroshi , Sasuga Saeko , Fukuda Hirotsugu , Umezu Mitsuo , Iwasaki Kiyotaka 
Published: November 2022

Abstract
Purpose
To compare the characteristics of reimplantation (RI) using grafts with sinuses and remodeling (RM) with/without external suture annuloplasty using a pulsatile flow simulator.

Methods
Porcine aortic roots were obtained from an abattoir, and six models of RM and RI with sinuses were prepared. External suture annuloplasty (ESA) was performed in the RM models to decrease the root diameter to 22 mm (RM-AP22) and 18 mm (RM-AP18). Valve models were tested at mean pulsatile flow and aortic pressure of 5.0 L/min and 120/80 (100) mmHg, respectively, at 70 beats/min. The forward flow, regurgitation, leakage, backflow rates, valve-closing time, and mean and peak pressure gradient (p-PG) were evaluated. Root configurations were examined using micro-computed tomography (micro-CT).

Results
The backflow rate was larger in the RM models than in the RI models (RI: 8.56% ± 0.38% vs. RM: 12.64% ± 0.79%; p < 0.01). The RM-AP and RI models were comparable in terms of the forward flow, regurgitation, backflow rates, p-PG, and valve-closing time. The analysis using a micro-CT showed a larger dilatation of the sinus of the Valsalva in the RM groups than in the RI group (Valsalva: RI, 26.55 ± 0.40 mm vs. RM-AP22, 31.22 ± 0.55 mm [p < 0.05]; RM-AP18, 31.05 ± 0.85 mm [p < 0.05]).

Conclusions
RM with ESA and RI with neo-sinuses showed comparable hemodynamics. ESA to RM reduced regurgitation.
Radiological predictors of shunt response in the diagnosis and treatment of idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis
Authors: Thavarajasingam Santhosh G. , El-Khatib Mahmoud , Vemulapalli Kalyan , Iradukunda Hector A. Sinzinkayo , K. Sajeenth Vishnu , Borchert Robin , Russo Salvatore , Eide Per K. 
Published: November 2022

Abstract

Background
Patients with the dementia subtype idiopathic normal pressure hydrocephalus (iNPH) may improve clinically following cerebrospinal fluid (CSF) diversion (shunt) surgery, though the predictors of shunt response remain debated. Currently, radiological features play an important role in the diagnosis of iNPH, but it is not well established which radiological markers most precisely predict shunt responsive iNPH.

Objective
To conduct a systematic review and meta-analysis to identify radiological predictors of shunt responsiveness, evaluate their diagnostic effectiveness, and recommend the most predictive radiological features.

Methods
Embase, MEDLINE, Scopus, PubMed, Google Scholar, and JSTOR were searched for original studies investigating radiological predictors of shunt response in iNPH patients. Included studies were assessed using the ROBINS-1 tool, and eligible studies were evaluated using a univariate meta-analysis.

Results
Overall, 301 full-text papers were screened, of which 28 studies were included, and 26 different radiological features were identified, 5 of these met the inclusion criteria for the meta-analysis: disproportionately enlarged subarachnoid space (DESH), callosal angle, periventricular white matter changes, cerebral blood flow (CBF), and computerized tomography cisternography. The meta-analysis showed that only callosal angle and periventricular white matter changes significantly differentiated iNPH shunt responders from non-responders, though both markers had a low diagnostic odds ratio (DOR) of 1.88 and 1.01 respectively. None of the other radiological markers differentiated shunt responsive from shunt non-responsive iNPH.

Conclusion
Callosal angle and periventricular changes are the only diagnostically effective radiological predictors of shunt responsive iNPH patients. However, due to the DORs approximating 1, they are insufficient as sole predictors and are advised to be used only in combination with other diagnostic tests of shunt response. Future research must evaluate the combined use of multiple radiological predictors, as it may yield beneficial additive effects that may allow for more robust radiological shunt response prediction.
Hotspot analysis of COVID-19 infection using mobile-phone location data
Authors: Kimura Yu , Seki Tatsunori , Miyata Satoshi , Arai Yusuke , Murata Toshiki , Inoue Hiroyasu , Ito Nobuyasu 
Published: November 2022

AbstractRestrictions on outdoor activities are required to suppress the COVID-19 pandemic. To monitor social risks and control the pandemic through sustainable restrictions, we focus on the relationship between the number of people going out and the effective reproduction number. The novelty of this study is that we have considered influx population instead of staying-population, as the data represent congestion. This enables us to apply our analysis method to all meshes because the influx population may always represent the congestion of specific areas, which include the residential areas as well. In this study, we report the correlation between the influx population in downtown areas and business districts in Tokyo during the pandemic considering the effective reproduction number and associated time delay. Moreover, we validate our method and the influx population data by confirming the consistency of the results with those of the previous research and epidemiological studies. As a result, it is confirmed that the social risk with regard to the spread of COVID-19 infection when people travel to downtown areas and business districts is high, and the risk when people visit only residential areas is low.
Development of an epileptic seizure prediction algorithm using R–R intervals with self-attentive autoencoder
Authors: Ode Rikumo , Fujiwara Koichi , Miyajima Miho , Yamakawa Toshikata , Kano Manabu , Jin Kazutaka , Nakasato Nobukazu , Sawai Yasuko , Hoshida Toru , Iwasaki Masaki , Murata Yoshiko , Watanabe Satsuki , Watanabe Yutaka , Suzuki Yoko , Inaji Motoki , Kunii Naoto , Oshino Satoru , Khoo Hui Ming , Kishima Haruhiko , Maehara Taketoshi 
Published: November 2022

AbstractEpilepsy is a neurological disorder that may affect the autonomic nervous system (ANS) from 15 to 20 min before seizure onset, and disturbances of ANS affect R–R intervals (RRI) on an electrocardiogram (ECG). This study aims to develop a machine learning algorithm for predicting focal epileptic seizures by monitoring R–R interval (RRI) data in real time. The developed algorithm adopts a self-attentive autoencoder (SA-AE), which is a neural network for time-series data. The results of applying the developed seizure prediction algorithm to clinical data demonstrated that it functioned well in most patients; however, false positives (FPs) occurred in specific participants. In a future work, we will investigate the causes of FPs and optimize the developing seizure prediction algorithm to further improve performance using newly added clinical data.