bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients’ Experiences of Weight Regain After Bariatric Surgery
Authors: Tolvanen Liisa , Christenson Anne , Surkan Pamela J. , Lagerros Ylva Trolle 
Published: January 2022

Abstract
Purpose
Bariatric surgery is a successful obesity treatment; however, an estimated 1/5 of patients have regained more than 15% of their body weight 5 years post-surgery. To increase the understanding of patients who experienced weight regain after bariatric surgery, we conducted a qualitative study.

Materials and Methods
We recruited 16 adult participants (4 men, 12 women) at an obesity clinic in Stockholm, Sweden, 2018 to 2019, and performed semi-structured individual interviews. The transcribed recorded interview data was analyzed with thematic analysis.

Results
Participants had undergone gastric bypass surgery on average 10 years prior to study and regained 36% (range 12 to 71%) of their weight from their nadir. Participants experienced challenges such as eating in social settings, loneliness, family difficulties, increases in appetite, and physical and mental health problems, which distracted them from weight management. Participants responded to weight regain with emotional distress, particularly with hopelessness, discouragement, shame, and frustration (theme: loss of control and focus). Nonetheless, participants experienced remaining benefits from the surgery, despite weight regain. Social support, self-care, and behavioral strategies were perceived as facilitators for weight management (theme: reducing the burden of weight management).

Conclusions
Weight regain after bariatric surgery was perceived to be an unexpected and difficult experience that induced hopelessness, discouragement, shame, and frustration. Results indicate that internal and external circumstances such as psychosocial factors, changes in appetite, and physical and mental health problems may contribute to loss of control over weight. Social support, self-care, and behavioral strategies might facilitate long-term post-surgical weight management.

Graphical abstract
The Role of Single Nucleotide Polymorphisms of Monoamine Oxidase B, Dopamine D2 Receptor, and DOPA Decarboxylase Receptors Among Patients Treated for Parkinson’s Disease
Authors: Zapała Barbara , Stefura Tomasz , Piwowar Monika , Czekalska Sylwia , Zawada Magdalena , Hadasik Maria , Solnica Bogdan , Rudzińska-Bar Monika 
Published: January 2022

AbstractThis study aimed to investigate the association between selected variants of genes related to dopamine metabolism pathways and the risk of and progression of Parkinson’s disease (PD). This prospective cohort study was conducted in one academic teaching hospital. The study was conducted on 126 patients diagnosed with idiopathic Parkinson’s disease. Blood samples were collected to conduct a genotyping of MAOB, DRD1, DRD2, and DDC genes. Genotype and allele frequencies of MAOB (rs1799836) variants were not associated with the course of PD. Genotype and allele frequencies of DRD2 (rs2283265) variants were associated with risk of dementia (p = 0.001) and resulted in parts II and III of the UPDRS scale (p = 0.001). Genotype and allele frequencies of DRD2 (rs1076560) variants were associated with risk of dementia (p = 0.001) and resulted in parts II and III of the UPDRS scale (p = 0.001). Genotype and allele frequencies of DDC (rs921451) variants were not associated with the course of PD.
NEO E-vita—NEO era!
Authors: Jakob Heinz , Mourad Fanar 
Published: January 2022

AbstractIn this review article, the history of the first commercially available thoracic aortic hybrid graft, the E-vita Open, later modified to the blood-impermeable E-vita Open Plus, is reported from its beginning in 2005 until its newest variation, the E-vita Open NEO, European conformity (CE) marked in 2020. Besides the background of its design and clinical experience in Essen, concomitant evolutionary steps in surgery as well as in strategic approaches like the hybrid operating room concept are displayed, finally leading to a well-rounded surgical package with a device that can be applied in all elective as well as emergency situations with complex arch involving aortic pathologies. With the E-vita Open NEO, now, surgery has been facilitated to convenient anastomosing in any of the arch zones, with the opportunity to use the island technique with a straight graft variation as well as individual head vessel anastomosing with either a trifurcated graft for zone 0 or the branched graft for zone 2 or 3 implantation. With its proven long-term stability, the surgical armamentarium to cope with complex multisegmental thoracic aortic pathologies has been significantly improved.
Connectivity Shapes Functional Diversity and Maintains Complementarity in Surf Zones on Exposed Coasts
Authors: Henderson Christopher J. , Gilby Ben L. , Olds Andrew D. , Mosman Jesse , Connolly Rod M. , Hyndes Glenn , Kelaher Brendan , Maslo Brooke , Williams Alan , Schlacher Thomas A. 
Published: January 2022

AbstractHabitat complexity and connectivity can influence the number of species and their diversity across a landscape. For the surf zones of ocean-exposed beaches, globally one of the longest habitat interfaces, the assumed low structural complexity, and apparent homogeneity, of the sandy seafloor habitats predicts low taxonomic and functional diversity. Here, we assessed how the configuration of the seascape and the context of different beach structure functional diversity and functional niche space of fish assemblages in surf zones. We expected that beaches that were well connected with highly productive and complex estuarine and reef habitats would support a greater level of functional diversity, and a greater degree of functional complementarity within different niches. We sampled surf zones at twenty-five beaches along 50 km of coastline in southeast Queensland, Australia. We calculated functional diversity and functional niche space using variation in the functional traits of fish assemblages. We found that increased proximity with nearby subtidal rocky reefs was the key feature of the coastline shaping functional diversity and functional niche space in surf zone fishes. These effects resulted in increased functional complementarity within a number of fish functional group niches when rocky reefs were nearby. We provide empirical evidence that habitat proximity can structure functional diversity and complementarity in the surf zones of ocean beaches, a system traditionally viewed as having low habitat heterogeneity. Our results highlight the focus management must take in conserving these highly connected ecosystems to avoid negative functional consequences.
Tracking mutation and drug-driven alterations of oncokinase conformations
Authors: Feichtner Andreas , Kugler Valentina , Schwaighofer Selina , Nuener Thomas , Fleischmann Jakob , Stefan Eduard 
Published: January 2022

SummaryNumerous kinases act as central nodes of cellular signaling networks. As such, many of these enzymes function as molecular switches for coordinating spatiotemporal signal transmission. Typically, it is the compartmentalized phosphorylation of protein substrates which relays the transient input signal to determine decisive physiological cell responses. Genomic alterations affect kinase abundance and/or their activities which contribute to the malignant transformation, progression, and metastasis of human cancers. Thus, major drug discovery efforts have been made to identify lead molecules targeting clinically relevant oncokinases. The concept of personalized medicine aims to apply the therapeutic agent with the highest efficacy towards a patient-specific mutation. Here, we discuss the implementation of a cell-based reporter system which may foster the decision-making process to identify the most promising lead-molecules. We present a modular kinase conformation (KinCon) biosensor platform for live-cell analyses of kinase activity states. This biosensor facilitates the recording of kinase activity conformations of the wild-type and the respective mutated kinase upon lead molecule exposure. We reflect proof-of-principle studies demonstrating how this technology has been extended to profile drug properties of the full-length kinases BRAF and MEK1 in intact cells. Further, we pinpoint how this technology may open new avenues for systematic and patient-tailored drug discovery efforts. Overall, this precision-medicine-oriented biosensor concept aims to determine kinase inhibitor specificity and anticipate their drug efficacies.
A risk scoring system based on tumor microenvironment cells to predict prognosis and immune activity in triple-negative breast cancer
Authors: Yang Anli , Wu Minqing , Ni Mengqian , Zhang Lijuan , Li Mingyue , Wei Peijun , Yang Yonggang , Xiao Weikai , An Xin 
Published: January 2022

AbstractThe tumor microenvironment (TME) interacting with the malignant cells plays a vital role in cancer development. Herein, we aim to establish and verify a scoring system based on the characteristics of TME cells for prognosis prediction and personalized treatment guidance in patients with triple-negative breast cancer (TNBC). 158 TNBC samples from The Cancer Genome Atlas (TCGA) were included as the training cohort, and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) (N = 297), as well as GSE58812 (N = 107), were included as the validation cohort. The enrichment scores of 64 immune and stromal cells were estimated by the xCell algorithm. In the training cohort, cells with prognostic significance were found out using univariate Cox regression analysis and further applied to the random survival forest (RSF) model. Based on the scores of M2 macrophages, CD8+ T cells, and CD4+ memory T cells, a risk scoring system was constructed, which divided TNBC patients into 4 phenotypes (M2low, M2highCD8+ThighCD4+Thigh, M2highCD8+ThighCD4+Tlow, and M2highCD8+Tlow). Furthermore, types 1 and 2 patients were merged into the low-risk group, while types 3 and 4 patients were in the high-risk group. The low-risk group had superior survival outcomes than the high-risk one, which was further confirmed in the validation cohort. Moreover, in the low-risk group, immune-related pathways were significantly enriched, and a higher level of antitumoral immune cells and immune checkpoint molecules, including PD-L1, PD-1, and CTLA-4, could be observed. Additionally, consistent results were achieved in the SYSUCC cohort when the scoring system was applied. In summary, this novel scoring system might predict the survival and immune activity of patients and might serve as a potential index for immunotherapy.
Onderzoeksopzet evaluatie Gezonde School: onder welke condities doet het ertoe?
Authors: Vennegoor Gerjanne , Vonk Lisanne , van Assema Patricia , Huijts Tim , Eekhout Iris , Molleman Gerard R. M. , Levels Mark , Jansen Maria W. J. 
Published: January 2022

SamenvattingHoewel steeds meer scholen het vignet Gezonde School hebben behaald, is weinig bekend over de factoren, kenmerken en processen, ofwel condities, die de effectiviteit van het programma Gezonde School beïnvloeden. Daarom wordt een evaluatieonderzoek uitgevoerd op drie niveaus: de leerling, de school en de regio. De drie centrale onderzoeksvragen zijn gericht op: 1) condities voor leerlinguitkomsten, 2) condities voor implementatie op school, en 3) condities voor regionale ondersteuning. Daarbij worden de school en de regio beschouwd als complexe adaptieve systemen. Condities voor beoogde uitkomsten op leefstijl, gezondheid en schoolprestaties van leerlingen worden onderzocht met een combinatie van bestaande databronnen waaraan schoolcodes kunnen worden toegevoegd. Goed en minder goed presterende scholen worden geselecteerd voor een overwegend kwalitatieve vervolganalyse om verschillen in uitkomsten verder te verklaren. Om inzicht te krijgen in condities voor implementatie op school en de regionale ondersteuning in negen GGD-regio’s wordt met een vragenlijst de implementatiegraad bepaald, om daarna scholen te selecteren voor overwegend kwalitatief vervolgonderzoek. Dit onderzoek biedt niet alleen inzicht in de huidige stand van zaken op de drie niveaus, maar kan ook verschillen in uitkomsten tussen leerlingen, scholen en regio’s verklaren. Zo kunnen concrete aangrijpingspunten worden gegeven om de implementatie van Gezonde School verder te versterken.
Gosha-Jinki-Gan Improved Erectile Dysfunction Caused by Anti-Cancer Agent Oxaliplatin by Decreasing Transcriptional Expression of Phosphodiesterase-5 in Rats
Authors: Kataoka Tomoya , Kawaki Yuto , Kito Yohei , Suzuki Jun , Mori Taiki , Hotta Yuji , Sanagawa Akimasa , Kawade Yoshihiro , Maeda Yasuhiro , Furukawa-Hibi Yoko , Kimura Kazunori 
Published: January 2022

Abstract

Background
A platinum-containing anti-cancer agent, oxaliplatin (L-OHP), is known to induce peripheral neuropathy, including erectile dysfunction (ED) as a side effect, while Gosha-jinki-gan (GJG) is a traditional Japanese herbal medicine mainly used for peripheral neuropathy.

Aim
To investigate the effect of GJG on L-OHP-induced ED in rats.

Methods
Twelve-week-old male Wister/ST rats were categorized into the following groups: Sham, Sham+GJG, L-OHP, and L-OHP+GJG (each n = 10). The L-OHP and L-OHP+GJG groups were injected intravenously with L-OHP (4 mg/kg) for 2 consecutive days in the first week. Statistical significance was determined using Bonferroni's multiple comparison test.

Outcomes
At the end of the study period, erectile function was evaluated by measuring intracavernosal pressure (ICP) and mean arterial pressure (MAP) after cavernous nerve stimulation. Western blot analysis was used to assess the neuronal nitric oxide synthase (nNOS) and endothelial nitric oxide synthase (eNOS) levels, and quantitative polymerase chain reaction was used to assess the expression of phosphodiesterase-5 (PDE-5) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-1.

Results
The ICP/MAP ratio of L-OHP rats (0.34 ± 0.06) was significantly lower than that of Sham rats (0.67 ± 0.03, P &lt; .01), however, the ICP/MAP ratio of L-OHP+GJG rats (0.55 ± 0.01) was significantly higher than that of L-OHP rats (P &lt; .01). There were no significant differences in the nNOS and eNOS protein expression between both groups (P &gt; .05). GJG administration significantly decreased PDE-5 and NADPH oxidase-1 messenger RNA expressions in the L-OHP+GJG group.

Clinical Translation
This animal model study suggests that GJG might be effective for erectile function in cancer survivors.

Strengths & limitations
Our study identified that GJG had no notable side effects in the treated group. Further investigation of the cavernous nerve would also help elucidate the mechanism of GJG effect, which is a limitation of this study.

Conclusion
We found that GJG administration improved L-OHP-induced ED by improving transcriptional PDE-5 expression.
A pilot model of a public–private partnership for implementation of a coronavirus disease 2019 (COVID-19) diagnostic testing program to facilitate a safe school reopening
Authors: Branch-Elliman Westyn , van den Berg Polly , Dong Sara W. , Kapoor Andrew K. , Merchant Elisabeth A. , Schechter-Perkins Elissa M. 
Published: January 2022

Abstract

Objective:
We developed an implementation plan to integrate diagnostic testing for coronavirus disease 2019 (COVID-19) into a public school system. Implementation barriers were identified and strategies were mapped to overcome them.

Design:
A COVID-19 diagnostic testing program leveraging a public–private partnership was developed for a public school system.

Setting:
A suburban school district and a local hospital during the 2020–2021 academic year.

Methods:
Using Consolidated Framework for Implementation Research (CFIR) constructs and evidenced-based implementation strategies, the program was designed as a “closed system” and was adapted based on stakeholder feedback. Implementation barriers and facilitators were identified and mapped to CFIR constructs to provide insights into factors influencing program adoption.

Results:
Preimplementation stages of engagement, feasibility, and readiness planning were completed. The program did not progress to implementation due to multiple factors, including changes in school leadership (inner setting and process-level constructs), improved access to outside testing, and lack of an existing paradigm for in-school testing (external constructs). Limited support from key stakeholders and opinion leaders was also a barrier (process-level construct).

Conclusions:
Although this locally initiated program did not progress beyond the preimplementation stage, the processes developed and barriers identified may be useful to inform planning efforts in other testing programs within public school systems. Future programs may consider incorporating multiplex diagnostic testing for influenza in addition to COVID-19. With relaxation of infection control measures, the prevalence of other respiratory viruses will increase. Actionable results will be needed to inform decisions about closures and quarantines.
Monitoring of COVID-19 pandemic-related psychopathology using machine learning
Authors: Enevoldsen Kenneth C. , Danielsen Andreas A. , Rohde Christopher , Jefsen Oskar H. , Nielbo Kristoffer L. , Østergaard Søren D. 
Published: January 2022

AbstractThe COVID-19 pandemic is believed to have a major negative impact on global mental health due to the viral disease itself as well as the associated lockdowns, social distancing, isolation, fear, and increased uncertainty. Individuals with preexisting mental illness are likely to be particularly vulnerable to these conditions and may develop outright ‘COVID-19-related psychopathology’. Here, we trained a machine learning model on structured and natural text data from electronic health records to identify COVID-19 pandemic-related psychopathology among patients receiving care in the Psychiatric Services of the Central Denmark Region. Subsequently, applying this model, we found that pandemic-related psychopathology covaries with the pandemic pressure over time. These findings may aid psychiatric services in their planning during the ongoing and future pandemics. Furthermore, the results are a testament to the potential of applying machine learning to data from electronic health records.
Vitamins, microelements and the immune system: current standpoint in the fight against coronavirus disease 2019
Authors: Djordjevic Branka , Milenkovic Jelena , Stojanovic Dijana , Velickov Aleksandra , Djindjic Boris , Jevtovic Stoimenov Tatjana 
Published: January 2022

AbstractCoronavirus disease 2019 (COVID-19) is an acute respiratory disease associated with severe systemic inflammation. The optimal status of vitamins and microelements is considered crucial for the proper functioning of the immune system and necessary for successful recovery. Most patients with respiratory distress in COVID-19 are vitamin and microelement deficient, with vitamin D and Se deficiency being the most common. Anyway, various micronutrient supplements are widely and arbitrarily used for prevention or in the treatment of COVID-19. We aimed to summarise current knowledge about molecular and physiological mechanisms of vitamins (D, A, C, B6, B9and B12) and microelements (Se, Zn, Cu and Fe) involved in the immune system regulation in consideration with COVID-19 pathogenesis, as well as recent findings related to their usage and effects in the prevention and treatment of COVID-19. In the early course of the pandemic, several, mainly observational, studies reported an association of some micronutrients, such as vitamin C, D and Zn, with severity reduction and survival improvement. Still, emerging randomised controlled trials showed no effect of vitamin D on hospitalisation length and no effect of vitamin C and Zn on symptom reduction. Up to date, there is evidence neither for nor against the use of micronutrients in the treatment of COVID-19. The doses that exceed the recommended for the general population and age group should not be used, except in clinical trials. Benefits of supplementation are primarily expected in populations prone to micronutrient deficiencies, who are, as well, at a higher risk of worse outcomes in COVID-19.
Considering escaping hell
Authors: Ani Emmanuel Ifeanyi 
Published: January 2022

AbstractAdams argues that the traditional doctrine of eternal hellish experience stretches the Problem of Evil beyond any reasonable solution, as hell is stubbornly incompatible with God's omnipotence, omniscience, and perfect goodness. Buckareff and Plug argue that people could leave hell. Matheson responds that if people could leave hell, people could leave heaven. But Matheson provides reasons to think that this is not possible. Luck attempts to refute Matheson's argument. I show that Luck's attempt contains analogies that lack features that crucially depict the asymmetrical relationship between heaven and hell. I advance some other analogies that I think contain such features.
SOME HOMOLOGICAL PROPERTIES OF CATEGORY FOR LIE SUPERALGEBRAS
Authors: CHEN CHIH-WHI , MAZORCHUK VOLODYMYR 
Published: January 2022

AbstractFor classical Lie superalgebras of type I, we provide necessary and sufficient conditions for a Verma supermodule
$\Delta (\lambda )$
to be such that every nonzero homomorphism from another Verma supermodule to
$\Delta (\lambda )$
is injective. This is applied to describe the socle of the cokernel of an inclusion of Verma supermodules over the periplectic Lie superalgebras
$\mathfrak {pe} (n)$
and, furthermore, to reduce the problem of description of
$\mathrm {Ext}^1_{\mathcal O}(L(\mu ),\Delta (\lambda ))$
for
$\mathfrak {pe} (n)$
to the similar problem for the Lie algebra
$\mathfrak {gl}(n)$
. Additionally, we study the projective and injective dimensions of structural supermodules in parabolic category
$\mathcal O^{\mathfrak {p}}$
for classical Lie superalgebras. In particular, we completely determine these dimensions for structural supermodules over the periplectic Lie superalgebra
$\mathfrak {pe} (n)$
and the orthosymplectic Lie superalgebra
$\mathfrak {osp}(2|2n)$
.
A compact dual band MIMO antenna for 5G/WLAN applications
Authors: Liu Gui , Zhang Chuanba , Chen Zhuoni , Chen Bo 
Published: January 2022

AbstractTo satisfy the increasing requirements of wireless communication, a compact dual band MIMO antenna is presented in this paper. The presented antenna consists of two symmetric radiating elements operating at both 3.5 and 4.5 GHz bands. To enhance the isolation between the two radiating elements, an I-shaped decoupling structure is introduced. The measured −10 dB reflection coefficients frequency bands are 3.3–3.8 and 4.3–5.8 GHz. The measured isolation S21 between the two radiating elements are better than 15 and 17 dB at the lower and higher frequency band, respectively. The overall dimension of the proposed antenna is 50 × 22 × 1.59 mm3. The measured result indicates that the proposed antenna can be a good candidate for 5 G/WLAN wireless communication.