bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibiotic allergy in children with cystic fibrosis: A retrospective case–control study
Authors: Süleyman Ayşe , Tamay Zeynep , Güler Nermin 
Published: July 2022

AbstractAntibiotic allergy is a big problem that may affect the treatment and life quality of patients with cystic fibrosis (CF).AimTo evaluate predictive factors for confirmed antibiotic hypersensitivity in children with CF.MethodsIn this case–controlled study, we examined 15 patients with CF who had been confirmed with antibiotic allergy. Additionally, we included a control group of age‐ and gender‐matched 45 CF patients with no antibiotic allergy. The diagnosis of antibiotic allergy was confirmed in the presence of a compatible history and a positive response in the drug skin test or provocation test. Multiple drug hypersensitivity was classified according to the temporal relationship of antibiotics: (i) distant, (ii) simultaneous, and (iii) sequential. The data were analyzed by conditional logistic regression.Resultsβ‐lactam allergy was confirmed in eight patients (ceftazidime n = 5, piperacillin‐tazobactam n = 3) and non‐β‐lactam allergy was confirmed in two patients (ciprofloxacin n = 1, azithromycin n = 1). Additionally, multiple drug hypersensitivity in five patients (distant n = 4, sequential n = 1), among whom two patients showed hypersensitivity against ceftazidime/piperacillin‐tazobactam+ ciprofloxacin/levofloxacin, two patients showed hypersensitivity against ceftazidime+ ciprofloxacin n = 2, and one patient showed hypersensitivity against piperacillin‐tazobactam+ amikacin+ trimethoprim‐sulfamethoxazole. All patients (n = 13) with confirmed β‐lactam allergy were meropenem tolerant. Multivariate analysis indicated that immediate reactions (, p < 0.001) and allergic evaluation in the first six months after the reaction (p = 0.036) were significant risk factors for the prediction of antibiotic hypersensitivity.ConclusionBeta‐lactam antibiotic allergy is the most commonly confirmed drug allergy in children with CF. However, unlike normal children, ceftazidime and piperacillin‐tazobactam account for the majority.
Molding Fabrication of High‐Energy Nanoparticles of Lead Azide Encapsulated by Graphene‐Doped Porous Carbon Matrix with Excellent Ignition Ability
Authors: Yan Zhenzhan , Wang Shuang , Yang Li , Han Jimin , Tong Wenchao 
Published: July 2022

AbstractIn this work, graphene oxide‐doped lead‐containing metal‐organic framework (BTC−Pb/GO) and polyvinyl alcohol were used as raw materials to prepare spherical or cylindrical lead azide composites by freeze‐drying, carbonization, and in‐situ azide steps. Nanoscale lead azide is uniformly distributed on the graphene‐doped porous carbon framework. Detailed characterization and testing show that LA/C/rGO exhibits excellent electrostatic sensitivity (1.94 J) and flame sensitivity (40 cm) due to the excellent electrical and thermal conductivity of porous carbon and graphene, which are superior to most of the previously reported modified lead azide.
Guaiacol as a natural melanin biosynthesis inhibitor to control northern corn leaf blight
Authors: Wang Delong , Li Min , Yuan Chunxia , Fang Yali , Zhang Zhijia 
Published: July 2022

AbstractBACKGROUNDThe natural 1,8‐dihydroxynaphthalene (DHN) melanin biosynthesis inhibitors (MBIs) are one of the promising approaches to the integrated management of plant diseases but have received scarce attention until now. Herein, to explore the natural DHN MBIs used in the control of northern corn leaf blight (NCLB), a library of 53 essential oil compounds was used to screen the MBIs against Exserohilum turcicum, the causal pathogen of NCLB, using tricyclazole as a reference compound.RESULTSThe results of morphological change in the colony, thermogravimetric analysis, ultraviolet–visible spectroscopy, and transmission electron microscopy confirmed that guaiacol could effectively inhibit the melanin production at 50 μg/mL under in vitro conditions. The in vitro bioassay results indicated that this inhibition effect was concentration‐dependent and the minimum inhibition concentration of guaiacol was 50 μg/mL. The in vivo experimental results demonstrated that guaiacol significantly inhibited appressorium formation and penetration on corn leaf sheaths at the concentration of 500 μg/mL. The pot experiment results revealed that there were no differences between guaiacol (500 μg/mL) and tricyclazole (100 μg/mL) in control efficacy. The enzymatic assay suggested that guaiacol might exert the activity through inhibiting DHN polymerization to form melanins, which was distinct from tricyclazole.CONCLUSIONSTaken together, this study screened out guaiacol as a natural MBI from 53 essential oil compounds and verified its effectiveness in the control of NCLB at 500 μg/mL. Above all, this research opened an avenue for exploring natural DHN MBIs in the integrated management of plant diseases. © 2022 Society of Chemical Industry.
Anti‐tumour necrosis factor‐α‐induced lupus in a patient receiving infliximab for sarcoidosis
Authors: Stranks Lachlan , Chapman Sally 
Published: July 2022

AbstractInfliximab is a chimeric monoclonal antibody against tumour necrosis factor (TNF)‐α, with a wide variety of uses. Monoclonal antibody therapies specifically targeting TNF‐α, have emerged as a novel treatment option for patients with refractory sarcoidosis, with infliximab being the most widely used. This is not true of other TNF‐α inhibitors, for example etanercept, which have a different mechanism of action, and are not effective in sarcoidosis. It is well documented that infliximab therapy can result in the production of autoantibodies, however clinical symptoms or disease is rare. In this report, we describe a 37‐year‐old male with a history of sarcoidosis requiring infliximab therapy, who presented during the course of his treatment with the onset of new migratory joint pain, increasing fatigue and positive serum autoantibodies, heralding the development of infliximab‐induced lupus.
The impact of COVID 19 on the outcomes of thrombectomy in stroke patients: A systematic review and meta‐analysis
Authors: El‐Qushayri Amr Ehab , Reda Abdullah , Dahy Abdullah , Azzam Ahmed Y. , Ghozy Sherief 
Published: July 2022

AbstractWe aimed to conduct the current meta‐analysis to provide better insight into the efficacy of mechanical thrombectomy (MT) in managing COVID‐19 patients suffering from a stroke. An electronic search was conducted through eight databases for collecting the current evidence about the efficacy of MT in stroke patients with COVID‐19 until 18 December 2021. The results were reported as the pooled prevalence rates and the odds ratios (ORs), with their corresponding 95% confidence intervals (CI). Out of 648 records, we included nine studies. The prevalence of stroke patients with COVID‐19 who received MT treatment was with TICI ≥2b 79% (95%CI: 73–85), symptomatic intracranial haemorrhage 6% (95%CI: 3–11), parenchymal haematoma type 1, 11.1% (95%CI: 5–23), and mortality 29% (95%CI: 24–35). On further comparison of MT procedure between stroke patients with COVID 19 to those without COVID‐19, we found no significant difference in terms of TICI ≥2b score (OR: 0.85; 95%CI: 0.03–23; p = 0.9). However, we found that stroke patients with COVID‐19 had a significantly higher mortality rate than stroke patients without COVID‐19 after MT procedure (OR: 2.99; 95%CI: 2.01–4.45; p < 0.001). Stroke patients with COVID‐19 can be safely and effectively treated with MT, with comparable reperfusion and complication rates to those without the disease.
The importance of institutional differences among countries in SDGs achievement: A cross‐country empirical study
Authors: Reverte Carmelo 
Published: July 2022

AbstractBased upon the “quintuple helix” model (Carayannis et al., 2012; Carayannis & Campbell, 2010), this research analyzes whether the differences in the level of achievement of the Sustainable Development Goals (SDGs) among 64 countries worldwide can be explained by a series of 19 institutional variables related to five dimensions such as cultural orientation, economic development, the education‐labor system, the political‐legal system and innovation. Our results highlight the crucial role of public policies in attaining SDGs through the improvement of institutional quality, governance systems and economic freedom as well as with the promotion of education and the innovation ecosystem. In this regard, the adoption of the “quintuple helix” model through the interrelation of the government, Universities and the private sector is deemed relevant in order to face the social and environmental challenges posed by the SDGs.
Multi‐project work and project performance: Friends or foes?
Authors: Colicev Anatoli , Hakkarainen Tuuli , Pedersen Torben 
Published: July 2022

AbstractResearch SummaryWhile multi‐project work (MPW) is becoming an increasingly popular work arrangement, its relationship with project performance is understudied. On the one hand, MPW is deployed to increase employee worktime utilization and productivity, which should be reflected in more timely project completion. On the other hand, MPW also brings switching costs due to attention residue and cognitive setup. Based on this trade‐off, we derive an inverted U‐shaped relationship between MPW and project performance. We find support for this relationship in a longitudinal dataset containing 9,649 project‐month‐employee observations. More specialized experience, project similarity, and employee familiarity positively moderate the inverted U‐shape. Furthermore, the results are robust to a host of model specifications, data structures, assumptions, and alternative explanations.Managerial SummaryHow many projects can you work on simultaneously? We study this question in the context of new product development (NPD) projects in a multinational organization. We suggest that multi‐project work (MPW) might be a double‐edged sword. On the one hand, MPW academics or engineers can be more productive by filling the gaps in their schedules and developing time management practices. On the other hand, MPW also carries switching costs. This trade‐off creates an inverted U‐shaped relationship between MPW and project performance. So, how can MPW be more beneficial or less costly? We find that more specialized employees can benefit more from productivity gains while working with familiar members or similar projects can alleviate switching costs.
Stimuli‐Responsive Electrochemical Energy Storage Devices
Authors: Parsimehr Hamidreza , Ehsani Ali 
Published: July 2022

AbstractElectrochemical energy storage (EES) devices have been swiftly developed in recent years. Stimuli‐responsive EES devices that respond to different external stimuli are considered the most advanced EES devices. The stimuli‐responsive EES devices enhanced the performance and applications of the EES devices. The capability of the EES devices to respond to the various external stimuli due to produced advanced EES devices that distinguished the best performance and interactions in different situations. The stimuli‐responsive EES devices have responsive behavior to different external stimuli including chemical compounds, electricity, photons, mechanical tensions, and temperature. All of these advanced responsiveness behaviors have originated from the functionality and specific structure of the EES devices. The multi‐responsive EES devices have been recognized as the next generation of stimuli‐responsive EES devices. There are two main steps in developing stimuli‐responsive EES devices in the future. The first step is the combination of the economical, environmental, electrochemical, and multi‐responsiveness priorities in an EES device. The second step is obtaining some advanced properties such as biocompatibility, flexibility, stretchability, transparency, and wearability in novel stimuli‐responsive EES devices. Future studies on stimuli‐responsive EES devices will be allocated to merging these significant two steps to improve the performance of the stimuli‐responsive EES devices to challenge complicated situations.
Metal‐Organic Frameworks Functionalized Separators for Lithium‐Sulfur Batteries
Authors: Chong Yu‐Liang , Zhao Dong‐Dong , Wang Bing , Feng Li , Li Si‐Jun , Shao Lan‐Xing , Tong Xin , Du Xuan , Cheng H. , Zhuang Jin‐Liang 
Published: July 2022

AbstractLithium sulfur batteries (LSBs) have attracted tremendous attention owing to their high theoretical specific capacity and specific energy. However, their practical applications are hindered by poor cyclic life, mainly caused by polysulfide shuttling. The development of advanced materials to mitigate the polysulfide shuttling effect is urgently demanded. Metal‐organic frameworks (MOFs) have been exploited as multifunctional materials for the decoration of separators owing to their high surface area, structural diversity, tunable pore size, and easy tailor ability. In this review, we aim to present the state‐of‐the‐art MOF‐based separators for LSBs. Particular attention is paid to the rational design (pore aperture, metal node, functionality, and dimension) of MOFs with enhanced ability for anchoring polysulfides and facilitating Li+transportation. Finally, the challenges and perspectives are provided regarding to the future design MOF‐based separators for high‐performance LSBs.
Property Rights, Tenure Form, and Tenure Security
Authors: Masuda Yuta J. , Robinson Brian E. , Holland Margaret B. 
Published: July 2022

AbstractLand tenure security is often inconsistently defined, conceptualized, and measured. This can create confusion in research and practice. Here, we provide a summary of the differences between property rights, tenure form, and land tenure security. The chapter provides a brief review of the history and evolution of research on these topics, how they intersect, and why distinguishing these concepts is important for research and practice.
Securing Communal Tenure Complemented by Collaborative Platforms for Improved Participatory Landscape Management and Sustainable Development: Lessons from Northern Tanzania and the Maasai Mara in Kenya
Authors: Timmins Hannah L. , Mupeta-Muyamwa Patricia , Marubu Jackson , Schouten Chira , Lekaita Edward , Peterson Daudi 
Published: July 2022

AbstractCommunity lands play a critical role in community well-being and conservation, but community lands can be at odds with statutory land systems. We present two case studies from the Kenya-Tanzania border that illuminates the risks of top-down approaches imposing misaligned privatized tenurial systems onto the community, and the potential of community-based organizations (CBO) to promote collaboration in a socially fractured landscape via communal titles. The case studies indicate that applying a private tenure system in a misaligned cultural setting can fracture cultural and ecological coexistence between communities and the land. CBOs can play a role in catalyzing collective action to resolve these issues. The full devolution of rights must be sensitive to communities’ culture, traditions, and history, while ensuring avenues for collective action.
A Historical Perspective on Land Tenure Security
Authors: Sunderlin William D. , Holland Margaret B. 
Published: July 2022

AbstractIn this chapter, we explore the forces that have shaped the current challenge of securing land tenure for those with little voice, power, and means. Focusing on the Global South, we identify trends in the ebb and flow of land tenure security and insecurity, distinguishing between those tied to agricultural-based societies and forest-dependent populations where relevant. We spotlight the broad arc of history tied to land access: the widespread acquisition of land by the powerful dating several centuries back, the partial restoration of local land access beginning in the mid-twentieth century (e.g., post-colonial governments, agricultural land reform and redistribution movements, and forest management devolution), the land-grabbing phenomenon and violence of recent years, and the current uncertainty over future directions for tenure security.
Championing Women’s Tenure Security
Authors: Fletschner Diana , Deo Shipra , Mhoja Monica 
Published: July 2022

AbstractEfforts around tenure security have largely followed a gender-blind approach, leaving behind millions of women who are consistently denied access and rights to land and ignoring experts’ claims that strengthening women’s tenure security can yield a host of socially desirable outcomes. This is bound to change dramatically with the Sustainable Development Goal (SDG) commitments made by governments around the world to ensure land rights for all women and men by 2030, as a foundational step to end poverty, ensure food security, and achieve gender equality. In this chapter, we explore why women’s tenure security matters, what is known about the extent of women’s tenure security, and what can be done as we collectively support governments’ SDG commitments around women’s land rights.
Land Tenure Insecurity and Climate Adaptation: Socio-Environmental Realities in Colombia and Implications for Integrated Environmental Rights and Participatory Policy
Authors: Castro Brianna , Kuntz Christina 
Published: July 2022

AbstractThis chapter explores how land tenure impacts households’ resilience and adaptive capacity in the face of a changing climate. Following a review of the ways in which climate change adds pressure to land availability and natural resources, the chapter highlights how land tenure can constrain individuals’ options to adapt to shifting environmental conditions. An exploration of a case study of protracted drought in an agricultural region of Bolivar, Colombia, demonstrates how landlessness, socioeconomic vulnerability, and confusion regarding complicated land tenure policies in a post-conflict environment guided families’ resilience strategies and adaptive capacities. This case demonstrates that it is necessary to nuance understandings of (in)secure tenure to include local knowledge of land policies and precarious tenure claims as predictors of adaptive capacities in vulnerable, climate-stressed regions.
Beyond Boom and Bust: Climate in the History of Medieval Steppe Empires (C. 550-1350 CE)
Authors: Di Cosmo Nicola 
Published: July 2022

AbstractThe use of paleoclimate data in historical work has become a new and dynamic endeavor in several areas of historical research. This chapter is concerned with the empires created by pastoral nomads in the steppe regions of Eastern and Central Eurasia over approximately three millennia, from the early appearance of complex Scythian and Siberian polities in the early first millennium BCE to the Dzungar empire of the seventeenth and eighteenth centuries. This essay aims to show how paleoclimate data may be used to illuminate connections, dynamics, and causal nexuses in the important, and yet often overlooked, historical experience of pastoral peoples and the empires they created. Paleoclimate data are especially important to supplement the scarce documentary sources left behind by pastoral nomads.
Panarchy and the Adaptive Cycle: A Case Study from Mycenaean Greece
Authors: Newhard James M. L. , Cline Eric H. 
Published: July 2022

AbstractIn this brief paper, we consider and apply the concept of Panarchy and the Adaptive Cycle to a case study from the ancient world, specifically the Mycenaeans at the end of the second millennium BCE. We suggest that the collapse of elite Mycenaean society can be conceptualized as a result of its over-reliance on a hyper-networked international system, whose disintegration brought about a cascading event upon the Aegean World. It may be useful to view the events in this area in terms of regional adaptive cycles and their engagement within and upon broader interconnected systems (Panarchy).
Managing the Roman Empire for the Long Term: Risk Assessment and Management Policy in the Fifth to Seventh Centuries
Authors: Haldon John , Elton Hugh , Izdebski Adam 
Published: July 2022

AbstractThis chapter analyses the reasons for the survival of the eastern Roman state from three different but complementary angles: imperial administration, the environmental conditions impacting land-use for the period, and the ability of the state to leverage resources. We conclude that a major contributory factor in survival was the effective use of natural resources and a self-reinforcing social-ecological system through which the state and its elites and infrastructure facilitated the survival of landscapes, generating the resources necessary for the state’s continued existence. In areas where this broke down—as in the western part of the empire—the Roman state in the long term disappeared.
The Environmental Dimension of Migration: The Case of Poland After World War II
Authors: Praczyk Małgorzata 
Published: July 2022

AbstractThe article deals with the environmental dimension of migrations. It takes as a case study the migration of Poles after 1945 that took place due to the post-war redrawing of political borders in Central Europe. Massive displacement of the populations, who were forced to leave towns and villages that they had inhabited for generations, resulted in disruptions of bonds with the natural environment and the domesticated landscape. The ways of dealing with this rupture and the ways of domesticating the new landscapes and natural environments are key problems discussed here. This analysis helps to better appreciate the environmental dimension of the 21st migrations we increasingly observe today.
Geoengineering and the Middle Ages: Lessons from Medieval Volcanic Eruptions for the Anthropocene
Authors: Bauch Martin 
Published: July 2022

AbstractThe existential challenge of mitigating anthropogenic climate change encouraged serious discussions on geoengineering approaches. One of them, Solar Radiation Management (SRM), would mean inserting aerosols into the atmosphere, thus imitating and perpetuating the cooling effects of large volcanic events, such as the 1815 Tambora eruption. However, artificially inserting sulphur aerosols into the atmosphere is connected with considerable uncertainties. One of them, pointed out by several climate scientists, is the different effects on temperature and precipitation in different parts of the globe. These are not the only ones, though. As the largest volcanic eruptions have taken place during the medieval times (ca 500–1500 CE), historical research can reveal further uncertainties in dating these eruptions and their connected socio-environmental effects, and hence on the actual climate and social impacts we might expect from SRM. A combination of humanist and scientific research on past volcanic eruptions therefore has the potential to produce a more precise understanding of past volcanic eruptions and their climatic consequences. As long as we do not acquire a consistent multi-disciplinary perspective on past volcanic eruptions, extreme caution should be taken before investing in geoengineering measures that include the artificial injection of sulphur aerosols in the atmosphere.
The SODALITE Runtime Environment
Authors: Kumara Indika , Quattrocchi Giovanni , RadoloviÄ‡ Dragan , Tokmakov Kamil , Rivas JesÃºs Ramos , Van Den Heuvel Willem-Jan 
Published: July 2022

AbstractModern applications need to be dynamically orchestrated on heterogeneous infrastructures for reasons such as performance, regulation compliance, or cost. This chapter presents the SODALITE runtime environment that can deploy, monitor, and manage applications on heterogeneous infrastructures consisting of Cloud, HPC, and Edge resources. The SODALITE runtime deploys the applications in the target infrastructures based on the deployment artifacts generated by the SODALITE model-driven approach presented in Chap. 3. It can also monitor the deployed applications and their infrastructure resources, generate alerts, and adapt application deployments.