bluuebunny/crossref_metadata_2025_split huggingface dataset:
IFNγ-IL-17-IL-22+CD4+ subset and IL-22-producing cells in tumor draining lymph nodes of patients with breast cancer
Authors: Salmanpour Ali , Rezaeifard Somayeh , Kiani Razie , Tahmasebi Sedigheh , Faghih Zahra , Erfani Nasrollah 
Published: September 2022

BACKGROUND: A recently introduced CD4+ T subset that mainly secretes interleukin (IL-) 22 has been reported to be associated with a variety of tumors, including colon, gastric, hepatocellular, and small- and large-cell lung carcinoma. Both tumor-promoting and - suppressing roles have been suggested for these cells. In the present study, we aimed to investigate the frequency of IL-22-producing subsets in tumor-draining lymph nodes (TDLNs) of the patients with breast cancer and determine their association with the clinicopathological characterizations of the disease. METHODS: Thirty untreated women diagnosed with breast cancer were enrolled and their axillary lymph nodes were dissected during surgery. Mononuclear cells were isolated using Ficoll density gradient, activated, permeabilized, and stained by fluorochrome-conjugated antibodies against CD4, IL-22, IL-17, and IFNγ. The cells were then acquired on the FACSCalibur flow cytometer, and raw data was analyzed by the FlowJo software package (V10). RESULTS: Our results demonstrated that 2.39% ± 0.39 of CD4+ lymphocytes in TDLNs of patients with breast cancer produced IL-22. Among them, 0.64% ± 0.8 just produced IL-22 but were negative for IFNγ and IL-17. Statistical analysis indicated that the frequency of CD4+IL-22+ cells was significantly higher in the patients with stage III and the ones with 3–9 tumor involved lymph nodes (N2) compared to those with stage II and those having 1–3 tumor involved lymph nodes (N1) (P = 0.008 and P = 0.004, respectively). CONCLUSION: The higher frequency of IL-22-producing cells in draining lymph nodes of patients with more advanced tumors (higher stage (stage III) and more involved lymph nodes) suggests a role for IL-22-producing cells in the tumor progression and invasion. However, further studies with larger sample size and more functional studies are needed to clarify the role of IL-22-producing cells in breast cancer pathogenesis.
Cryogenic hydrogen Moderator infrastructure at ESS
Authors: Beßler Yannick , Natour Ghaleb 
Published: September 2022

The European Spallation Source (ESS) in Lund, Sweden, is designed to become the most powerful spallation neutron source in the world. As one subsystem of the Target Station, which was developed and built at Central Institute of Engineering, Electronics and Analytics – Engineering and Technology (ZEA-1) of Forschungszentrum Juelich, the cold Moderator slows down high-energy neutrons from the spallation process. To gain maximum neutron flux intensities along with high system availability for condensed and soft matter research, an optimized liquid hydrogen Moderator circuit has been developed. Hydrogen with a pressure around 1 MPa, a temperature around 20 K, and a para-hydrogen fraction of at least 0.995 will be utilized to interact with neutrons in a unique cold Moderator vessel arrangement. Hydrogen conversion from ortho- to para-hydrogen will be controlled using a catalyst. Two turbo pumps are arranged in series and circulate the cryogen. A helium refrigerator, the Target Moderator Cryoplant (TMCP), continuously recools the hydrogen mass flow. Pressure stabilization is achieved by a pressure control buffer. The individual ESS Cryogenic Moderator System (CMS) components, the first and second generation of hydrogen Moderators (BF1 and BF2) and a first draft of a deuterium Moderator upgrade are presented.
Article Impact of Foreign Direct Investment on CO2 Emissions in South Asian Countries: The Moderating Role of Institutions
Authors: Rana Arslan Tariq , Shabbir Iqra , Ilyas Ansari Dr Muhammad 
Published: September 2022

This study investigates the moderating role of institutional quality on the empirical relationship between FDI and Carbon dioxide emission for panel of South Asian regions for the period 1996-2019 by using Dynamic OLS (DOLS) estimations. The literature on Pollution Haven Hypothesis (PHH) is extensive but the influencing role of institutions affecting the PHH is relatively limited especially in the context of South Asian economies. Unit Root test, Pedroni Cointegration test, Dynamic OLS, FMOLS and VECM methods has been used for the estimation of results. The significant moderating effect of institutions is observed on the association between Foreign Direct Investment and Carbon dioxide emissions. Firstly, we examined the relationship between Foreign Direct Investment and Carbon dioxide emissions and found out that Foreign Direct Investment increases Carbon dioxide emissions; hence the presence of PHH is found for South Asian countries. Then the institutions were introduced to analyze their moderating effects. The results show that mediating role of institutional quality is crucial in the nexus between FDI and CO2 emission. In the presence of quality institutions, Foreign Direct Investment significantly decreases the level of CO2 emission.
IMPLEMENTASI BALANCE SCORE CARD PERSPEKTIF PENJAMINAN MUTU PENDIDIKAN ISLAM
Authors: Nabilah Nisrina , Abidin Munirul 
Published: September 2022

Abstract The orientation of this article is to investigate and examine more deeply the meaning of the balance score card, aspects of the balance score card and its implementation in the perspective of quality assurance of Islamic education. In this paper, the author tries to analyze more deeply and systematically in implementing new management strategies that can encourage quality improvement in institutions by using a balanced score card approach based on Islamic principles. The type of research in this article uses a library research approach in which data collection techniques are obtained from various primary references and secondary data which are then reduced and keyed. Research results: (1). Application of Balance Score Card in Islamic Education Quality that is balanced both financially (profit) and non-financially (non-profit), (2). Standardization of Performance Measures from the Perspective of the Balance Score Card (in terms of finance, customers, internal business processes and learning and growth). With a comprehensive performance measurement that does not only measure financial but combines financial and non-financial measures, educational institutions can carry out better organizational performance. Keywords: Balance Score Card; Quality Assurance; Islamic Education. Abstrak Orientasi artikel ini untuk menyelisik dan menelaah lebih dalam makna balance score card, aspek balance score card dan implementasinya dalam perspektif penjaminan mutu Pendidikan Islam. Dalam tulisan ini penulis mencoba menganalisis lebih dalam serta sistematis dalam menerapkan strategi manajemen baru yang dapat mendorong peningkatan mutu di lembaga dengan menggunakan pendekatan balance score card disandari dengan prinsip-prinsip Islam. Jenis penelitian dalam artikel ini menggunakan pendekatan Library research yang mana teknik pengumpumlan data diperoleh dari pelbagai referensi primer dan sekunder yang kemudian data direduksi dan disimpulkan. Hasil penelitian: (1). Penerapan Balance Score Card dalam Mutu Pendidikan Islam yang secara seimbang baik secara financial (profit) dan non-financial (non-profit), (2). Standarisasi Ukuran Keberhasilan Kinerja Perspektif Balance Score Card (dalam aspek keuangan, pelanggan, proses bisnis internal dan pembelajaran dan pertumbuhan). Dengan pengukuran kinerja yang komprehensif tidak hanya mengukur keuangan tetapi menggabungkan ukuran keuangan dan non-keuangan, lembaga pendidikan dapat menjalankan kinerja organisasi yang lebih baik. Kata Kunci: Balance Score Card; Penjaminan Mutu; Pendidikan Islam.
An Architecture Of Shifting Mores: Transforming the Modern Downtown
Authors: Mitchener Konner S. 
Published: September 2022

<p> Since its inception, modernism has represented an embrace of changing socioeconomic conditions and has been characterized as a medium for enacting social change. Modernism is both shaped by and contributes to the moulding of changing social mores. The built fabric acts as an indicator of cultural values but is also acted upon by its inhabitants to reflect shifting social norms. An architecture reflective of shifting mores embraces this duality and uses it to instill a sense of optimism for the future. </p>
<p>This thesis contends that modernism embodies a cycle of everevolving values and cultural shifts. As collective opinions change and socioeconomic conditions are transformed, it is essential that we demand new uses and meanings from our built environment. An architecture of shifting mores diverges from traditional modernist thinking. We can no longer wipe the slate clean to serve our shifting needs. This thesis is sited in London, Ontario’s Downtown Heritage Conservation District where ideas of pragmatism, hybridity, innovation, and shifting mores were tested on a city block, resulting in the proposed design framework. This thesis responds to the conditions of modernization that have resulted in the city as we know it. The framework being proposed puts cultural heritage at the forefront of city building while finding creative, new uses for underutilized infrastructure. </p>
مقاربات في الاعلام ، الدور والتعبئة
Authors: سميسم حميدة 
Published: September 2022

ثمة اشكالية طبيعية تثيرها مسالة الاداء الاعلامي . بوصفه نشاطا مستقلا بذاته ومعبرا عن قدرات خاصة به ، وهذه الاشكالية يمكن صياغتها في شكل تساؤل مفاده:
هل الاداء الاعلامي مجرد انعكاس لنشاط قطاعات المجتمع الاخرى ولاسيما السياسة والاقتصادية وما يربط بينهما وبين قطاعات مجتمعية اخرى من علاقات متشابكة؟ وهل يقتصر عمل الاعلام على مجرد النقل، ام انه صناعة لها الياتها وقواعدها؟
El Plan de Social Media Marketing como estrategia para mejorar el posicionamiento de marca de un estudio de diseño arquitectónico. Caso: Estudio de diseño “Arq. Pamela Flores”
Authors: Vaca-Paredes Darío , Vidal-Fernández Pablo 
Published: September 2022

El Social Media Marketing es una tendencia en continuo ascenso, que permite diseñar nuevas estrategias que ayudarán a cumplir los objetivos de las organizaciones. Dentro del campo de la construcción, específicamente de los estudios de diseño arquitectónico, un plan de Social Media Marketing permite llegar de manera directa al segmento de clientes mediante el uso de las redes sociales. El propósito de este trabajo fue realizar un plan de Social Media Marketing para mejorar el posicionamiento de marca del estudio de diseño “Arq. Pamela Flores”. El estudio es de carácter mixto, para lo cual se realizaron encuestas a la muestra definida, así como una entrevista a la propietaria del estudio. La metodología del plan propuesto para este estudio, fue llevada a cabo basándose en 3 fases. Primeramente, se realizó un diagnóstico del Social Media propio y de la competencia, seguidamente se definieron la audiencia y el buyer persona, posteriormente se seleccionaron las redes sociales sobre las cuales se va a trabajar, así como el contenido más idóneo y, finalmente, se propuso un plan de evaluación de desempeño del plan. Se concluyó que existe una débil presencia de marca en redes sociales, así como la poca gestión de la competencia en el ecosistema digital, suponen una oportunidad comercial de generar ventajas competitivas mediante estos canales (redes sociales) aumentando el alcance, notoriedad y grado de influencia en el público objetivo. El siguiente paso será orientar la estrategia hacia un incremento sostenible de las ventas, acompañado del desarrollo de una marca personal.
Palabras clave: plan de social media marketing, redes sociales, social media, arquitectura y diseño, brand awareness
SIFAT FISIK VCO HASIL FERMENTASI SELAMA ≥ 24 JAMMENGGUNAKAN RAGI TEMPE DENGAN KONSENTRASI NUTRISI YEAST 2% B/V
Authors: Purnamasari Ita , Lusiani Cucuk Evi 
Published: September 2022

Negara Indonesia merupakan negara agraris yang memiliki SDA (Sumber Daya Alam) dan lahan yang melimpah sehingga dapat dimanfaatkan sebagai lahan perkebunan kelapa. Pemanfaatan kelapa khususnya bagian buah salah satunya dapat digunakan untuk menghasilkan VCO (Virgin Coconut Oil). Pembuatan VCO dapat dilakukan secara konvensional dengan metode fermentasi. Tujuan dari penelitian ini adalah untuk menentukan pengaruh waktu fermentasi terhadap warna, rasa, aroma, pH, dan, %yield VCO yang dihasilkan dari proses fermentasi dengan ragi tempe. Pembuatan VCO diawali dengan pembuatan larutan starter untuk mengaktifkan yeast yang dilakukan dengan cara menambahkan ragi tempe (yeast) dan nutrisi yeast (konsentrasi 2% b/v) ke dalam tangki pre-fermentor sederhana. Larutan starter selanjutnya dicampur dengan santan untuk dilakukan fermentasi selama 24, 30, 36 jam. Produk VCO yang dihasilkan dianalisis untuk mengetahui sifat fisik dari VCO yang meliputi warna, rasa, aroma, pH, dan %yield dari produk VCO. Berdasarkan hasil analisis sifat fisik dari VCO, dapat disimpulkan bahwa sifat fisik VCO sesuai dengan SNI 7381.2008 yaitu transparan, memiliki rasa seperti minyak kelapa, aroma seperti santan atau kelapa segar, nilai pH sebesar 5,5 dan nilai %yield tertinggi (11,30%) yang dihasilkan pada waktu fermentasi selama 36 jam.
Perancangan Sistem Hybrid Solar Cell dan PLN Menggunakan Solar Charger Controller dan Voltage Sensor
Authors: Haqiqi Aditya Ainul , Patma Tundung Subali , Fathoni Fathoni 
Published: September 2022

Kebutuhan energi di dunia terus meningkat sedangkan sumber energi fosil yang digunakan terus menipis, sehingga dibutuhkan suatu energi alternatif untuk memasok kebutuhan energi. Skripsi ini merancang sistem hibrid antara solar cell, baterai, PLN untuk mensuplai beban DC 12V. Sistem ini menggunakan solar cell sebesar 50wp dan mengalami keadaan puncak pada pukul 12.00 dengan menghasilkan tegangan 21,10V, arus 0,39A dan daya sebesar 8,07W. Tegangan keluaran dari solar cell akan masuk ke Solar Charger Controller untuk diatur daya output sehingga bisa digunakan untuk charging accu. Penyearah digunakan untuk mengubah tegangan AC 220V menjadi tegangan DC 12V. Untuk switch sumberdaya digunakan Relay dengan trigger data dari Voltage Sensor. Keadaan baterai 100% ketika tegangan mencapai 12,71V dan dilakukan pengisian ketika keadaan baterai 30%-40% dengan tegangan sebesar 11,8V. untuk sistem pengisian daya dikontrol oleh Solar Charger Controller sedangkan untuk Sistem hybrid dengan pemindahan sumberdaya dikontrol oleh Arduino melalui Voltage Sensor. Agar tegangan pada batterai bisa dibaca oleh Arduino maka dibutuh pembagi tegangan dengan nilai maksimal 5V, pembagi tegangan ini akan menjadi satu rangkaian dengan Voltage Sensor.
The druggable genome: Twenty years later
Authors: Radoux Chris J. , Vianello Francesca , McGreig Jake , Desai Nikita , Bradley Anthony R. 
Published: September 2022

The concept of the druggable genome has been with us for 20 years. During this time, researchers have developed several methods and resources to help assess a target’s druggability. In parallel, evidence for target-disease associations has been collated at scale by Open Targets. More recently, the Protein Data Bank in Europe (PDBe) have built a knowledge base matching per-residue annotations with available protein structure. While each resource is useful in isolation, we believe there is enormous potential in bringing all relevant data into a single knowledge graph, from gene-level to protein residue. Automation is vital for the processing and assessment of all available structures. We have developed scalable, automated workflows that provide hotspot-based druggability assessments for all available structures across large numbers of targets. Ultimately, we will run our method at a proteome scale, an ambition made more realistic by the arrival of AlphaFold 2. Bringing together annotations from the residue up to the gene level and building connections within the graph to represent pathways or protein-protein interactions will create complexity that mirrors the biological systems they represent. Such complexity is difficult for the human mind to utilise effectively, particularly at scale. We believe that graph-based AI methods will be able to expertly navigate such a knowledge graph, selecting the targets of the future.
A deep learning approach for anterior cruciate ligament rupture localization on knee MR images
Authors: Qu Cheng , Yang Heng , Wang Cong , Wang Chongyang , Ying Mengjie , Chen Zheyi , Yang Kai , Zhang Jing , Li Kang , Dimitriou Dimitris , Tsai Tsung-Yuan , Liu Xudong 
Published: September 2022

Purpose: To develop and evaluate a deep learning-based method to localize and classify anterior cruciate ligament (ACL) ruptures on knee MR images by using arthroscopy as the reference standard.Methods: We proposed a fully automated ACL rupture localization system to localize and classify ACL ruptures. The classification of ACL ruptures was based on the projection coordinates of the ACL rupture point on the line connecting the center coordinates of the femoral and tibial footprints. The line was divided into three equal parts and the position of the projection coordinates indicated the classification of the ACL ruptures (femoral side, middle and tibial side). In total, 85 patients (mean age: 27; male: 56) who underwent ACL reconstruction surgery under arthroscopy were included. Three clinical readers evaluated the datasets separately and their diagnostic performances were compared with those of the model. The performance metrics included the accuracy, error rate, sensitivity, specificity, precision, and F1-score. A one-way ANOVA was used to evaluate the performance of the convolutional neural networks (CNNs) and clinical readers. Intraclass correlation coefficients (ICC) were used to assess interobserver agreement between the clinical readers.Results: The accuracy of ACL localization was 3.77 ± 2.74 and 4.68 ± 3.92 (mm) for three-dimensional (3D) and two-dimensional (2D) CNNs, respectively. There was no significant difference in the ACL rupture location performance between the 3D and 2D CNNs or among the clinical readers (Accuracy, p &lt; 0.01). The 3D CNNs performed best among the five evaluators in classifying the femoral side (sensitivity of 0.86 and specificity of 0.79), middle side (sensitivity of 0.71 and specificity of 0.84) and tibial side ACL rupture (sensitivity of 0.71 and specificity of 0.99), and the overall accuracy for sides classifying of ACL rupture achieved 0.79.Conclusion: The proposed deep learning-based model achieved high diagnostic performances in locating and classifying ACL fractures on knee MR images.
A xylan assisted surface-enhanced Raman scattering substrate for rapid food safety detection
Authors: Xiang Zhouyang , He Mengyun , Li Li , Bobokalonov Jamshed , Dzhonmurodov Abduvali , Ji Xingxiang 
Published: September 2022

Cellulose fiber/paper-based surface-enhanced Raman scattering (SERS) is considered as a promising food safety detection technology due to its non-toxicity, low cost, flexibility, and hygroscopicity for possible rapid on-site agricultural product contaminant detection. However, it faces the problems of poor noble metal adhesion and toxic noble metal reducing agent. In this study, a natural macromolecule—xylan was used as both a reducing agent and a stabilizing agent to prepare stable Au-Ag bimetal nanoparticles, which were anchored on the paper surface by xylans in order to fabricate a paper-based Au-Ag bimetallic SERS substrate. The results show that the SERS substrate has a high Raman enhancement performance and reproductively. The substrate can effectively detect trace pesticide, i.e., thiram, and the limit of detection is as low as 1 × 10–6 mol/L (0.24 ppm). In addition, the paper-based SERS substrate can be used for direct detection of pesticide residues on the surface of fruit. The paper-based SERS substrate developed in this study has great potential in applications for rapid food safety detection.
Engineering diabetic human skin equivalent for in vitro and in vivo applications
Authors: Abedin-Do Atieh , Zhang Ze , Douville Yvan , Méthot Mirelle , Bernatchez Julien , Rouabhia Mahmoud 
Published: September 2022

The prevalence of diabetes is increasing worldwide. Diabetes contributes to 70% of all non-traumatic lower-limb amputations, which are directly caused by diabetic foot ulcers (DFU) that are difficult to heal. Non-healing diabetic ulcers represent one of modern society’s most difficult medical challenges. One of the promising initiatives to treat DFU is the grafting of autologous skin or stimulating the skin cells at the edge of the wound to proliferate and close the wound. The present study was to engineer a diabetic human skin equivalent (DHSE) that contains fibroblasts and keratinocytes extracted from the skin collected from diabetic patients. The DHSE was used to investigate whether exposure to low-intensity electrical stimulation (ES) could promote diabetic cell activity. The ES was generated by a direct current (DC) electric field of 20 or 40 mV/mm. We demonstrated that the fibroblasts and keratinocytes could be extracted from older diabetics, cultured, and used to engineer DHSE. Interestingly, the exposure of DHSE to ES led to a structural improvement through tissue stratification, increased Ki-67 expression, and the deposition of basement membrane proteins (laminin and type IV collagen). The DHSE exposed to ES showed a high level of keratin 5 and 14 expressions in the basal and supra-basal layers. The keratinocyte proliferation was supported by an increased secretion of the keratinocyte growth factor (FGF-7). Exposure to ES decreased the activity of metalloproteinases (MMP) 2 and 9. In conclusion, we extracted keratinocytes and fibroblasts from the skin of diabetic-old donors. These cells were used to engineer skin equivalents and demonstrate that ES can promote diabetic wound healing. This DHSE can be a promising tool for various in vitro studies to understand the wound healing mechanisms under chronic inflammatory conditions such as diabetes. The DHSE could also be used as an autologous substrate to cover the DFU permanently.