bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of methods for standardization of the active substance, namely the model mixture based on decamethoxine and thiotriazoline
Authors: Kucherenko L. I. , Chonka O. O. , Portna O. O. 
Published: January 2022

Today, the important problem is the creation of new decamethoxine and thiotriazoline based drugs for the treatment of stomatitis.
The aim of the work is to develop a method for quantitative determination of decamethoxine and thiotriazoline in the model mixture (1:25) by spectrophotometry.
Materials and methods. Series 6 model mixtures were made at the ratio of decamethoxine and thiotriazoline 1:25. We used certified substances: thiotriazoline series GTT 3460911 (manufacturer: State Enterprise Chemical Reagents Plant, Kharkiv), decamethoxine series № 010915 (manufacturer: LLC “PHARMCHIM”). Optizen POP spectrophotometer, polyvinyl alcohol, hydrochloric acid, and eosin were used.
Results. A method for quantitative determination of decamethoxine and thiotriazoline in MS was developed. It was established that the content of active substances in MS is thiotriazoline from 0.5021 to 0.5096, decamethoxine from 0.0207 to 0.0211.
Conclusions. A method for quantitative determination of decamethoxine and thiotriazoline in MS has been developed. The method of quantitative determination of decamethoxine and thiotriazoline in MS is reproducible.
The state of carotid artery wall in hypertensive patients with gout based on the study of inflammatory markers
Authors: Kuzmina H. P. , Lazarenko O. M. 
Published: January 2022

The aim. To analyze the frequency of atherosclerotic lesions of the carotid arteries and association with the lipid metabolism and inflammatory markers in hypertensive patients with gout.
Materials and methods. 122 patients with hypertension aged 30 to 65 years were examined (mean age (56.0 (47.0; 62.0)), inclu­ding 104 men (85.2 %) and 18 women (14.8 %). Group 1 included 72 hypertensive patients with gout; group 2 – 50 hypertensive patients without gout; group 3 – 20 gout patients without hypertension. Serum levels of high sensitivity C-reactive protein were detected by enzyme-linked immunosorbent assay. Serum ferritin levels were measured using electrochemiluminescent detection. The patients underwent carotid artery ultrasound according to standard methods.
Results. The duration of gout exacerbation and the pain intensity evaluated with the visual analog scale (VAS) (P < 0.01) were significantly higher in group 1, than those in group 3 (P < 0.01). Serum ferritin levels were 2.6 (P < 0.01) times higher in group 1 than those in group 2. In patients with gout, the levels of ferritin were significantly 2.1 times higher, than in group 2 (P < 0.01). The levels of hsСRP in patients of group 1 were 3.1 times higher than those in group 2 (P < 0.01). The proportion of patients with intima-media complex (IMC) thickness ≥0.9 mm was higher in group 1 than in groups 2 (χ2 = 4.58, P < 0.05) and 3 (χ2 = 24.96, P < 0.01). In the structure of plaques, isoechoic were significantly more often seen among group 1 patients as compared to group 3 (χ2 = 6.56, P < 0.01), and hyperechoic – as compared to group 2 (χ2 = 4.63, P < 0.05). Hypoechoic plaques were detected in groups 1 and 2 with similar frequency (P > 0.05). This type of plaque was associated with a high risk of cerebrovascular events. In the patients with arterial hypertension and gout, a significant moderate positive correlation was found between the IMC thickness and the serum uric acid level (rs = 0.46, P < 0.01), hsCRP (rs = 0.33, P < 0.01), age (rs = 0.33; P < 0.01), duration of gout (rs = 0.27, P < 0.05) and VAS (rs = 0.39, P < 0.01); the level of hsCRP was correlated with the presence of atherosclerotic plaques (τ = +0.64, P < 0.05).
Conclusions. The combination of hypertension with gout in patients was associated with a high incidence of IMC thickness ≥0.9 mm and atherosclerotic plaques, more severe disorders of purine and lipid metabolism, increased inflammatory markers (ferritin and hsCRP), that should be considered not only in the aspect of chronic inflammation, but also as a part of the disease.
Pathogenetic role of intestinal microflora in carbohydrate malabsorption syndrome in early-aged children with rotavirus infection
Authors: Vorobiova N. V. , Usachova O. V. , Kaplaushenko A. H. 
Published: January 2022

The aim is to evaluate the effect of metabolic activity of intestinal microflora on laboratory manifestations of carbohydrate malabsorption syndrome in early-aged children with rotavirus infection by studying the main intestinal metabolites – short-chain fatty acids in faeces.
Materials and methods. 60 breastfed children with rotavirus infection aged 1–24 months were examined. The total amount of carbohydrates in faecal samples was determined using Benedict’s test, and the detection of short-chain fatty acids in faeces was carried out using liquid chromatography in the dynamics of the disease – on the 3rd, 5th and 10th day.
Results. It was established, that the amount of reducing sugars in faeces decreased with the increasing concentration of intestinal microflora metabolites during the entire period of rotavirus infection. In patients with ≤0.5 % level of carbohydrates in faeces, the total content of short-chain fatty acids was the highest and exceeded by 2.0, 1.8 and 1.7 times the indicators of children with Benedict’s test values >0.5 % on the 3rd, 5th and 10th days of the disease, respectively (p < 0.05). A decrease in the metabolic activity of the intestinal microbiota in the above category of children occurred mainly due to a deficiency in the production of acetic and propionic acids (P < 0.05). In the acute period of the disease, an imbalance in the intestinal microbiota infrastructure was noted towards a deficiency of obligate anaerobes that was expressed in a decrease in the anaerobic index (P < 0.05). The severity of these disorders influenced the severity of carbohydrate malabsorption: with an increase in the level of undigested sugars in faeces >0.5 %, the anaerobic index values were 3 and 5 times lower than at a carbohydrate level ≤0.5 % on the 3rd and 5th days of the disease, respectively (P < 0.05).
Conclusions. It has been found that early-aged children with rotavirus infection have structural and functional disorders of the intestinal microflora, which influence the severity of carbohydrate malabsorption syndrome. The lower the saccharolytic activity of intestinal bacteria, the more pronounced the manifestations of this syndrome during the entire period of the disease.
Use of tocilizumab in the combination treatment of a COVID-19 patient with concomitant rheumatoid arthritis (a case report)
Authors: Vizir V. A. , Sadomov A. S. , Demidenko O. V. 
Published: January 2022

The aim is to familiarize practitioners with the clinical case of tocilizumab use in the combination treatment of the coronavirus disease (COVID-19) patient with concomitant rheumatoid arthritis.
Materials and methods. The clinical case shows our own follow-up of COVID-19 clinical course in the patient with concomitant rheumatoid arthritis during combination treatment with the use of a recombinant humanized anti-interleukin-6 receptor monoclonal antibody tocilizumab.
Results. The patient with a severe COVID-19 course, whose examination and treatment results are given in the article, was comorbid for rheumatoid arthritis. The cytokine storm development at the hospital stage was confirmed by an increase in markers of systemic inflammation: C-reactive protein, D-dimer, fibrinogen, an almost 50-fold increase in serum interleukin-6 level, as well as absolute and relative lymphocytopenia. Despite the anti-inflammatory therapy administered with systemic corticosteroids, the patient’s condition progressively worsened. After assessing the indications and contraindications, it was decided to use the interleukin-6 receptor inhibitor tocilizumab, followed by rapid clinical, laboratory and X-ray positive response to the treatment. The understanding of tocilizumab use in patients with COVID-19 at the current stage was formed based on the comparative analysis of our own clinical case data and the results of relevant clinical trials, world recommendations and guidelines.
Conclusions. The use of recombinant humanized anti-interleukin-6 receptor monoclonal antibody tocilizumab in the combination treatment of severe COVID-19 with concomitant rheumatoid arthritis is pathogenetically based and decreases the main clinical and laboratory signs of cytokine storm, respiratory failure, improves chest x-ray findings and reduces the length of hospital stay. Further large randomized placebo-controlled trials including the population of patients with various comorbid conditions are needed to clarify conclusively the place and role of anti-cytokine drugs in the treatment of COVID-19 patients.
Parameters of obtaining tincture from underground organs of Sanguisorba officinalisand study its biological activity
Authors: Oproshanska T. V. , Khvorost O. P. 
Published: January 2022

The aim of the work is to experimentally determine the optimal parameters for obtaining a tincture of rhizomes with roots of Sanguisorba officinalis and to investigate its antimicrobial and antioxidant activity.
Materials and methods. Rhizomes with roots of Sanguisorba officinalis were harvested in autumn 2019. When establishing the optimal parameters of the technology of obtaining tincture, the evaluation criterion was the number of the sum of polyphenols and the amount of hydroxycinnamic acids, which were determined by spectrophotometric method according to the methods of the State Pharmacopoeia of Ukraine 2.0. Antimicrobial activity was studied by agar diffusion and serial dilutions, antioxidant – in vitro using a stable radical 2,2-diphenyl-1-picrylhydrazyl (2,2-diphenyl-1-picrylhydrazyl – DPPH).
Results. The optimal parameters for obtaining a tincture of rhizomes with roots of Sanguisorba officinalis was extraction method maceration at room temperature, raw material-finished product ratio 1:5, time 48 hours, extractant 50 % ethyl alcohol, the number of polyphenols, and the number of hydroxycinnamic acids in terms of dry raw materials not less than 4.0 % and 1.5 % respectively. The resulting tincture exhibits antimicrobial activity against microorganisms Bacillus subtilis ATCC 6633 (growth retardation 26.40 ± 1.04 mm), Staphylococcus aureus ATCC 25923 (growth retardation 24.60 ± 0.68 mm) and Pseudomonas aeruginosa ATCС 27853 (growth retardation 23.60 ± 0.68 mm) and at a dose of 0.02 ml showed antioxidant activity at the level of 70 %.
Conclusions. The parameters of obtaining a tincture of rhizomes with roots of Sanguisorba officinalis were determined and its antimicrobial and antioxidant activity was studied.
Experimental identification of the subjective reception of external stimuli during wheelchair driving
Authors: Chwalik-Pilszyk Gabriela , Dziechciowski Zygmunt , Kromka-Szydek Magdalena , Kozień Marek S. 
Published: January 2022

Abstract
The aim of this article is identification of the subjective reception of external stimuli during wheelchair driving by analyses of vibration signals obtained from measurements. The identification concerns the impact of vibrations generated during crossing various types of pavements on the discomfort feelings of the selected human body parts (mainly the spine). The identification used the measurements of the whole body vibrations received by the user of the wheelchair. The research focuses mainly on the analysis in the frequency ranges corresponding to the vibration resonance of the spine. It is because respondents of the conducted surveys selected the spine as one of the most sensitive parts of the body.
Semantische Wissensnetze – vertrauenswürdige KI für innovative Businessanwendungen
Authors: Munk Katharina 
Published: January 2022

Zusammenfassung
Semantische Software-Technologien verwandeln große Mengen strukturierter und unstrukturierter Daten zu computerlesbaren und computerverwertbaren Wissensnetzen. Aufbau und Pflege der Wissensnetze gelingen im agilen Zusammenspiel zwischen Mensch und Computer. Mit angepassten Editoren, Natural Language Processing, semantischer Klassifikation und selbstlernenden Prozessen reifen sukzessive und zunehmend Kontext- und Textverständnis.
Solche Wissensnetze liefern erklärbare und nachvollziehbare Resultate. Sie sind für Forschung und Unternehmen jeder Branche von großem Wert und öffnen die Tür für innovative Anwendungen sowohl unternehmensintern als auch für Kunden: Beispiele sind Redaktionssysteme und Produktinformationssysteme mit inhaltlicher und formaler Unterstützung für neue digitale Informationsdienste sowie -Produkte, 360°-Input für Business-Entscheidungen und Suche und dynamische Aggregation semantischer Zusammenhänge im Bestandscontent.
Border Disputes: Religious Adjudication Along the Private/Public Divide
Authors: Aronson Ori 
Published: January 2022

Abstract
The article uses Israel’s volatile jurisdictional dynamics of the past two decades concerning access to religious community justice, as a telling case for examining the way legal pluralism is deployed along the public–private divide. The Israeli case exhibits a complex combination of an ostensibly liberal democratic regime, a commitment to a particularistic ethno-national political project, structural entanglements of state and religion against the backdrop of an unsettled constitutional order, and an historically diffuse mode of often-illiberal normative ordering within its diverse religious communities. All this provides a rich backdrop for various strategies by communal and institutional elites seeking to consolidate power, legitimacy, and authenticity in their often mutually-reliant jurisdictional projects. The article explores several salient episodes from Israel’s religious jurisdiction dynamics, focusing for purposes of analytical clarity on the case of Jewish orthodox legality. The analysis uncovers the main strategies stakeholders resort to, and shows how agency flows in different ways, with the choices of each player affecting the possibilities of the others. The institution at the arguable top of the system—the Supreme Court—is shown to be often devoid of effective means of elucidating, let along imposing, a coherent vision for a fragmented jurisdictional field. Conceptually, the judicial forum is revealed as the locus of an ongoing, uneasy engagement among normative imaginaries in a sometimes-competitive, sometimes-collaborative negotiation over coherence, tolerance, authority, and legitimacy.
Solving One-Side Polarization: Supreme Court Polarization and Politicization in Israel and the U.S.
Authors: Porat Iddo 
Published: January 2022

Abstract
The Israeli Supreme Court has become increasingly polarized between liberal and conservative judges. This phenomenon is relatively new to the Israeli Supreme Court and follows the much older and more well-known example of the U.S. Supreme Court. This article surveys both U.S. and Israeli court polarization and shows the history, reasons, and special features of polarization of both courts, including the important differences between them. It also adds a distinction to existing literature on court polarization—the distinction between court polarization and politicization, and especially the distinction between “regular” polarization and “one-side” polarization. Regular court polarization happens when the court is divided roughly equally between the two main political contenders (usually between right and left). One-side polarization happens when there is a clear advantage to one side of the political map in the make-up of the court. The current U.S. Supreme Court, with six conservative justices and only three liberal justices, is an example of one-side court polarization that is tilted to the right. The current Israeli Supreme Court (as of the writing of these lines) is an example for one-side court polarization tilted to the left; there are 10 liberal judges and only five conservative judges on the court. The article’s main argument is that one-side court polarization presents a particularly vexing problem for the legitimacy of the court, even more so than “regular” polarization. The article concludes with a survey of possible solutions to help Israel retract itself from one-side court polarization.
Light activation of 3D-printed structures: from millimeter to sub-micrometer scale
Authors: Jeong Hoon Yeub , An Soo-Chan , Jun Young Chul 
Published: January 2022

Abstract
Three-dimensional (3D) printing enables the fabrication of complex, highly customizable structures, which are difficult to fabricate using conventional fabrication methods. Recently, the concept of four-dimensional (4D) printing has emerged, which adds active and responsive functions to 3D-printed structures. Deployable or adaptive structures with desired structural and functional changes can be fabricated using 4D printing; thus, 4D printing can be applied to actuators, soft robots, sensors, medical devices, and active and reconfigurable photonic devices. The shape of 3D-printed structures can be transformed in response to external stimuli, such as heat, light, electric and magnetic fields, and humidity. Light has unique advantages as a stimulus for active devices because it can remotely and selectively induce structural changes. There have been studies on the light activation of nanomaterial composites, but they were limited to rather simple planar structures. Recently, the light activation of 3D-printed complex structures has attracted increasing attention. However, there has been no comprehensive review of this emerging topic yet. In this paper, we present a comprehensive review of the light activation of 3D-printed structures. First, we introduce representative smart materials and general shape-changing mechanisms in 4D printing. Then, we focus on the design and recent demonstration of remote light activation, particularly detailing photothermal activations based on nanomaterial composites. We explain the light activation of 3D-printed structures from the millimeter to sub-micrometer scale.
Structure and properties of two new heteroleptic bismuth(III) dithiocabamates of the general composition Bi(S2CNH2)2X (X = Cl, SCN)
Authors: Teske Christoph Ludwig , Terraschke Huayna , Mangelsen Sebastian , Bensch Wolfgang 
Published: January 2022

Abstract
The title compounds were prepared by precipitation from acidic solutions of the reactants in acetone/water. Bi(S2CNH2)2Cl (1) crystallizes in the non-centrosymmetric trigonal space group P32 with a = 8.6121(3) and c = 11.1554(4) Å, Z = 3; Bi(S2NH2)2SCN (2) in P21/c (monoclinic) with a = 5.5600(2), b = 14.3679(5), c = 12.8665(4) Å, and β = 90.37(3)°. In the crystal structure of 1 Bi3+ is in a sevenfold coordination of two bidentate and one monodentate S2CHNH2
− anions with an asymmetric coordination pattern of five Bi–S and two Bi–Cl− bonds. The linkage of these polyhedra via common Cl–S edges leads to a 1D polymeric structure with undulated chains propagating in the direction [001]. These chains are linked by strong and medium strong hydrogen bonds forming the 3D crystal structure. In the crystal structure of 2 the Bi3+ cation is in an eightfold coordination. The polyhedron can be described as a significantly distorted tetragonal anti-prism, capped by an additional S atom. Two of these prisms share a common quadrilateral face to form a “prism-double” (Bi2S10N2). These building units are linked by common edges, and the resulting 1D infinite angulated chains propagate along [100]. By contrast to organo-dithiocarbamate compounds, where C–H···X bridges are dominant, the interchain connections in the crystal structures of 1 and 2 are formed exclusively via N–H···S, N–H···Cl, and N–H···N interactions, generating the 3D networks. A significant eccentricity of the Bi3+ cation in the crystal structures of both complexes is observed. Both compounds emit light in the orange range of the electromagnetic spectrum.
Capitalismo de plataformas, producción y consumo de música: el caso de Spotify
Authors: Masís González Tadeo 
Published: January 2022

En el marco de los recientes cambios tecnológicos y económicos mediados por un capitalismo algoritmizado, este trabajo estudia la transformación que supone la entrada de la plataforma Spotify en la industria musical, así como sus implicaciones en cuanto al consumo y la producción de la música. Particularmente, se incluyen consideraciones para el caso particular de América Latina. Este análisis supone una revisión de los cambios recientes en la economía digital de la música a través de la noción de mundos del arte. Se evidenció el surgimiento de un nuevo actor en la industria de la música que va a asumir roles como la distribución de obras musicales y la curaduría artística, alterando así las redes de cooperación y dependencia en la industria de la música. Estas transformaciones no ocurren únicamente a una escala global, sino que pueden tener efectos potenciales para el caso latinoamericano.
Palabras clave: industria cultural; economía cultural; sociología del arte; cambio tecnológico; capitalismo
Developing of Bluetooth mesh flooding between source-destination linking of nodes in wireless sensor networks
Authors: Mohsin Shaymaa Kadhim , Mohammed Maysoon A. , Yassien Helaa Mohammed 
Published: January 2022

Bluetooth uses 2.4 GHz in ISM (industrial, scientific, and medical) band, which it shares with other wireless operating system technologies like ZigBee and WLAN. The Bluetooth core design comprises a low-energy version of a low-rate wireless personal area network and supports point-to-point or point-to-multipoint connections. The aim of the study is to develop a Bluetooth mesh flooding and to estimate packet delivery ratio in wireless sensor networks to model asynchronous transmissions including a visual representation of a mesh network, node-related statistics, and a packet delivery ratio (PDR). This work provides a platform for Bluetooth networking by analyzing the flooding of the network layers and configuring the architecture of a multi-node Bluetooth mesh. Five simulation scenarios have been presented to evaluate the network flooding performance. These scenarios have been performed over an area of 200×200 meters including 81 randomly distributed nodes including different Relay/End node configurations and source-destination linking between nodes. The results indicate that the proposed approach can create a pathway between the source node and destination node within a mesh network of randomly distributed End and Relay nodes using MATLAB environment. The results include probability calculation of getting a linking between two nodes based on Monte Carlo method, which was 88.7428 %, while the Average-hop-count linking between these nodes was 8. Based on the conducted survey, this is the first study to examine and demonstrate Bluetooth mesh flooding and estimate packet delivery ratio in wireless sensor networks