bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biosimilar erythropoiesis‐stimulating agents are an effective and safe option for the management of myelofibrosis‐related anemia
Authors: Inzoli Elena , Crisà Elena , Pugliese Novella , Civettini Ivan , Lanzarone Giuseppe , Castelli Andrea , Martinelli Vincenzo , Montelisciani Laura , Antolini Laura , Gambacorti‐Passerini Carlo , Elli Elena Maria 
Published: December 2022

AbstractObjectivesErythropoiesis‐stimulating agents (ESA) have an established role in treating anemia in hematological malignancies. However, their role, particularly biosimilar ESA (B‐ESA), in myelofibrosis (MF) is not well established.MethodsThis study retrospectively collected data on 96 MF patients treated with B‐ESA (alpha/zeta) for the management of anemia to assess safety, efficacy (anemia response [AR]), and survival.ResultsSeventy‐seven patients (80%) obtained AR. The median time to AR was 2.5 months. In multivariate analysis, significant predictive factors of AR were transfusion independency (p = .006) and ferritin levels <200 ng/ml (p = .009) at baseline. After a median follow‐up of 43.8 months from diagnosis, 38 patients (39%) died, 11 (28.9%) from leukemic evolution. Only two patients (2.5%) stopped B‐ESA for toxicity. The 24‐month survival was significantly affected by response to B‐ESA (70.8% in AR vs. 55.3% in non‐responder patients, p = .016). In multivariate analysis, age ≤ 70 years (p = .029) and Hb > 8.5 g/dl (p = .047) at baseline were significantly associated with improved survival, with a trend for longer survival in AR patients (p = .06).ConclusionsB‐ESA seems to be an effective and well‐tolerated option for anemia treatment in the MF setting. This strategy deserves further clinical investigation.
Applying symptom dynamics to accurately predict influenza virus infection: An international multicenter influenza‐like illness surveillance study
Authors: Li Jin‐Hua , Wu Chin‐Chieh , Tseng Yi‐Ju , Han Shih‐Tsung , Pekosz Andrew , Rothman Richard , Chen Kuan‐Fu 
Published: December 2022

AbstractBackgroundPublic health organizations have recommended various definitions of influenza‐like illnesses under the assumption that the symptoms do not change during influenza virus infection. To explore the relationship between symptoms and influenza over time, we analyzed a dataset from an international multicenter prospective emergency department (ED)‐based influenza‐like illness cohort study.MethodsWe recruited patients in the US and Taiwan between 2015 and 2020 with: (1) flu‐like symptoms (fever and cough, headache, or sore throat), (2) absence of any of the respiratory infection symptoms, or (3) positive laboratory test results for influenza from the current ED visit. We evaluated the association between the symptoms and influenza virus infection on different days of illness. The association was evaluated among different subgroups, including different study countries, influenza subtypes, and only patients with influenza.ResultsAmong the 2471 recruited patients, 45.7% tested positive for influenza virus. Cough was the most predictive symptom throughout the week (odds ratios [OR]: 7.08–11.15). In general, all symptoms were more predictive during the first 2 days (OR: 1.55–10.28). Upper respiratory symptoms, such as sore throat and productive cough, and general symptoms, such as body ache and fatigue, were more predictive in the first half of the week (OR: 1.51–3.25). Lower respiratory symptoms, such as shortness of breath and wheezing, were more predictive in the second half of the week (OR: 1.52–2.52). Similar trends were observed for most symptoms in the different subgroups.ConclusionsThe time course is an important factor to be considered when evaluating the symptoms of influenza virus infection.
Unraveling the physicochemical and toxicological properties of food product isolated E341/E171
Authors: Athinarayanan Jegan , Khaibary Amjad A. L. , Periasamy Vaiyapuri Subbarayan , Alatiah Khalid A. , Shamlan Ghalia , Alshatwi Ali A. 
Published: December 2022

AbstractNanostructured materials have been extensively exploited in the food sector for nutrient delivery, sensing, packaging, and food additives. It has exhibited size, shape, chemical nature, and surface area‐dependent physicochemical and biological properties. Currently, nanoscale ingredients are identified in approved food additives. Still, food‐grade nanostructured material's impact on biological systems is unexplored well. Thus, in this study, we have identified and analyzed the physicochemical properties of nanoscale ingredients in commercial food product isolate E341 and E171 combinations. Also, we have evaluated the E341/E171 combination cytotoxic potential on human mesenchymal stem cells. The food isolated E341/E171 exhibits spherical nature with a 60–200 nm diameter. The E341 and E171 combination exposure increased the cell viability loss to ~36% at a high dose in human mesenchymal stem cells (hMSCs). The E341/E171 treatment‐induced cellular and nuclear damage at a moderate dose. The mitochondrial membrane potential loss and ROS generation were observed in E341/E171 treated cells. The E341/E171 alters the gene expression pattern in hMSCs dose‐dependently. The GSR and POR gene expression is upregulated significantly in E341/E171 treatment. Our study results revealed that E341/E171 induced toxicity in hMSCs at high concentrations. Thus, E341/E171 potential impact on the biological system should be reexamined for food industrial implications.
Intervention during the Perinatal Period: Synthesis of the Clinical Practice Guidelines from the French National College of Midwives
Authors: Barasinski Chloé , Zaros Cécile , Bercherie Julie , Bernard Jonathan Y. , Boisseau Nathalie , Camier Aurore , Chanal Corinne , Doray Bérénice , Dugravier Romain , Evrard Anne , Ficheux Anne‐Sophie , Garlantézec Ronan , Kadawathagedara Manik , Laurent‐Vannier Anne , Lecorguillé Marion , Marie Cécile , Molénat Françoise , Pelé Fabienne , de Villepin Brune Pommeret , Rigourd Virginie , Rousseau Mélie , Storme Laurent , Weiss Stéphanie , Salinier Catherine , Béranger Rémi 
Published: December 2022

AbstractThese clinical practice guidelines from the French National College of Midwives (CNSF) are intended to define the messages and the preventive interventions to be provided to women and co‐parents by the different professionals providing care to women or their children during the perinatal period. These guidelines are divided into 10 sections, corresponding to 4 themes: 1/ the adaptation of maternal behaviors (physical activity, psychoactive agents); 2/ dietary behaviors; 3/ household exposure to toxic substances (household uses, cosmetics); 4/ promotion of child health (breastfeeding, attachment and bonding, screen use, sudden unexplained infant death, and shaken baby syndrome). We suggest a ranking to prioritize the different preventive messages for each period, to take into account professionals’ time constraints.
Newborns' Bonding and Attachment, Their Rhythms and Needs, Supporting Parents Appropriately: Guidelines for Interventions During the Perinatal Period from the French National College Of Midwives
Authors: Dugravier Romain , Molenat Françoise , Fourneret Pierre , Salinier‐Rolland Catherine 
Published: December 2022

AbstractA newborn's sleep‐wake rhythms are very specific, neurologically determined, and different from the pattern of adults; they require an adaptable and predictable response by parents, which will promotes bonding and attachments, constructed at the early stages of development. It also will influence the quality of subsequent emotional relationships and adaptation to life events. This parental adaptability should receive multiprofessional support starting in the perinatal period, focused on the screening and management of psychological vulnerability.
A Novel, Image-Based Method for Characterization of the Porosity of Additively Manufactured Bone Scaffolds With Complex Microstructures
Authors: Abdelgaber Yousef , Klemstine Cole , Salary Roozbeh (Ross) 
Published: December 2022

Abstract
Bone tissue engineering has emerged as a promising strategy for the treatment of osseous fractures, defects, and ultimately diseases caused by, for example, bone tumor resection, accident trauma, and congenital malformation. Additive fabrication of stem cell-seeded, osteoconductive porous scaffolds has been an effective method in clinical practice for the treatment of bone pathologies (such as osteoporosis, osteoarthritis, and rheumatic diseases). Porosity is known to be one of the main morphological characteristics of bone tissues, which affects the functional performance of an implanted bone scaffold. Hence, in situ detection and quantification of scaffold porosity implemented to ensure functional integrity prior to implantation/surgery is an unavoidable need. The objective of this research work is to introduce a robust, image-based method for identification and subsequently characterization of the surface porosity and dimensional accuracy of additively manufactured bone tissue scaffolds, with a focus on pneumatic micro-extrusion (PME) process. It was observed that the presented method would be capable of detecting complex individual pores based on a micrograph. Using the proposed method, not only were scaffold pores detected, but also scaffold porosity was characterized on the basis of various defined quality metrics/traits (such as the relative standard deviation of distance to the nearest pore). The proposed method was validated by contrasting its performance in “surface pore detection” against that of a standard method, tested on a complex benchmark in four different simulated lighting environments. Besides, the performance of the method in terms of “pore filling” was compared to that of a standard method, tested on a real PME-fabricated bone scaffold. It was observed that the proposed method had a better performance in pore filling, detection, and consolidation. Overall, the outcomes of this work pave the way for high-resolution fabrication of patient-specific, structurally complex, and porous bone scaffolds with easily validatable, functional, and medical properties for the treatment of bone pathologies.
A High-Accuracy Algorithm for Solving Problems of Electrostatics in a Nonhomogeneous Spatially Periodic Dielectric Medium
Authors: Kriksin Yu. A. , Tishkin V. F. 
Published: December 2022

Abstract—
A high-accuracy economical iterative method is proposed for calculating the potential and the strength of the electric field in a three-dimensional inhomogeneous spatially periodic dielectric placed in an initially uniform electric field. The idea underlying the algorithm is that the potential is represented as a sum of a linear function and a spatially periodic correction, which can be expressed as an expansion in eigenfunctions of the Laplace operator that satisfy the appropriate periodicity conditions. The fast Fourier transform is used for an efficient numerical implementation of the proposed algorithm.
Bilateral adrenal and pulmonary haemorrhages as an initial presentation of polycythaemia vera
Authors: Cilia Kyle , Borg Janice , Bugeja Maria , Farrugia Emanuel 
Published: December 2022

We report a case of a man in his early 60s presenting with bilateral adrenal and pulmonary haemorrhages as an initial presentation of polycythaemia vera (PV). Symptomatology included severe compressive chest pain radiating to epigastrium, with unremarkable physical findings, parameters and ECG. Blood investigations showed an elevated haemoglobin (174 g/L, reference range (RR): 141-172g/L) and haematocrit (55.7%, RR: 40.4%–50.4%) levels.Cross-sectional imaging excluded aortic dissection, but imaging repeated 48 hours after his admission for acute dyspnoea and worsening abdominal pain showed bilateral alveolar and adrenal haemorrhages. Cortisol level was 27 nmol/L (RR: 145–619 nmol/L). Investigations confirming PV included the presence of a Janus kinase 2 (JAK2V617F) gene mutation, hypercellularity with erythroid hyperplasia on bone marrow microscopy and a low serum erythropoietin (2.6 mIU/mL, RR: 4.3–29.0 mIU/mL). Aspirin, hydroxyurea, venesection and cortisol replacement were initiated to get good treatment outcome.
Managing hypertension in a Rohingya refugee camp: a brief report
Authors: Hamilton David , Sultana Moomtahin , Ho Lee Lee , Arai Mikiko , Businge Edward , Lukwata Robert , Maina Allen Gidraf Kahindo , Khadka Mira , Wright Joy 
Published: December 2022

Non-communicable diseases have overtaken communicable diseases as the most common cause of death worldwide, with the majority of these deaths in low-income and middle-income countries. Hypertension alone causes over nine million deaths per year.Since 2017, around 750 000 Rohingya refugees have fled violence in Myanmar into Cox’s Bazar District in Bangladesh. We describe a quality improvement project focused on the management of hypertension in Rohingya refugees in three primary health facilities within the Rohingya refugee camps. The aim of the project was to create a sustainable hypertension service within existing primary care services.A number of plan–do–study–act cycles were performed to improve care, with methods including: creating a specialised clinic, writing a treatment algorithm, training of pharmacists, engaging community health workers and educational programmes for staff and patients.In 2020, 554 patients were engaged in the new hypertension service. Of these, 358 (64.6%) returned for follow-up at least once. Mean systolic blood pressure (BP) was 141.7 (SD 60.0) mm Hg and mean diastolic BP was 88.1 (SD 11.1) mm Hg. Patients engaged in treatment had a significant reduction of BP of 8.2 (95% CI 5.4 to 11.0)/6.0 (95% CI 4.1 to 7.9) mm Hg (p<0.0001).Our project shows that it is possible to create a hypertension service in a challenging humanitarian crisis, which can successfully improve the control of hypertension, although retention in care can be difficult.
Development and implementation of a quick reference (QR) code linked online education tool in anaesthesiology practice
Authors: Diczbalis Monica , Liu Yi Tian , Young Donald J , Vaghadia Himat 
Published: December 2022

BackgroundWe conducted a feasibility study of an anaesthetic online educational tool that is accessed via quick reference (QR) codes. The primary objective of the study was to assess the feasibility of an online educational tool for providing satisfactory teaching to patients presenting for surgery and assess if using QR codes are a viable method for directing patients to the information. The secondary objective was to obtain feedback from anaesthesiologists.MethodsThe educational tool was developed and hosted on a password-protected website. The educational material on the website focused on anaesthesia-related processes that the patient should expect to experience in the hospital as well as fasting information. A survey was embedded into the website to obtain patient feedback. The website was redesigned following patient and staff feedback.ResultsNinety-three patients accessed the online education tool. Of the 73 responses to the survey, 81% of patients reported that the tool improved their knowledge and understanding about anaesthesia. 73% of patients expressed a preference for, or were neutral regarding using online patient education. 36% of patients were familiar with QR codes and 28% were frequent users of QR codes. Most anaesthesiologists expressed satisfaction with the tool being used by their patients following the redesign process (93.1%, 89.6% and 89.6% for general anaesthesia, neuraxial anaesthesia and regional anaesthesia, respectively).ConclusionsThis feasibility study demonstrated that an online anaesthetic educational tool has utility in promoting patient education about the anaesthetic experience and was well received by both patients and anaesthesiologists. QR codes are not feasible as the sole method for linking our patient population to an online education resource.
A Model Review on Joint Optimization of Part Quality Inspection Planning, Buffer Allocation, and Preventive Maintenance in SMMS
Authors: Gaber Yomna H. , El-Khodary Ihab A. , Abdelsalam Hisham M. 
Published: December 2022

In serial multi-stage manufacturing systems (SMMS), optimization of part quality inspection planning (PQIP), buffer allocation problem (BAP), and preventive maintenance (PM), individually and jointly, is attracting researchers’ attention. The model formulation for complicated manufacturing systems and the previously mentioned joint decisions is very beneficial given the interdependencies between the various manufacturing functions. As a result, this paper evaluates the literature on joint optimization of the multi-stage serial production system. The literature is classified based on the decision variables basis to represent each manufacturing function [inspection sample size and allocation (PQIP), buffer sizing and allocation (BAP), and preventive maintenance scheduling (PM)], and a general example model is presented in each classification, with a summary of recent studies, solution methods, research gaps, and future research recommendations. In the integrated models, almost all the studies considered only two functions, with that it is worth noting that research into the optimization of over two functions is still in its beginning. Furthermore, most studies neglected many of the real industrial settings that should also be integrated into the model. And finally, there was no specific solution technique recommended in the literature, yet a general simulation optimization method was used to generate and evaluate the combinatorial complex joint models.
Associations of Renal Cell Carcinoma Subtype with Patient Demographics, Comorbidities, and Neighborhood Socioeconomic Status in the California Population
Authors: Lichtensztajn Daphne Y. , Hofer Brenda M. , Leppert John T. , Brooks James D. , Chung Benjamin I. , Shah Sumit A. , DeRouen Mindy C. , Cheng Iona 
Published: December 2022

Abstract

Background:
Renal cell carcinoma (RCC) subtypes differ in molecular characteristics and prognosis. We investigated the associations of RCC subtype with patient demographics, comorbidity, and neighborhood socioeconomic status (nSES).

Methods:
Using linked California Cancer Registry and Office of Statewide Health Planning and Development data, we identified history of hypertension, diabetes, and kidney disease prior to RCC diagnosis in Asian/Pacific Islander, non-Latino Black, Latino, and non-Latino White adults diagnosed with their first pathologically confirmed RCC from 2005 through 2015. We used multinomial multivariable logistic regression to model the association of demographics, comorbidity, and nSES with clear-cell, papillary, and chromophobe RCC subtype.

Results:
Of the 40,016 RCC cases included, 62.6% were clear cell, 10.9% papillary, and 5.9% chromophobe. The distribution of subtypes differed strikingly by race and ethnicity, ranging from 40.4% clear cell and 30.4% papillary in non-Latino Black adults to 70.7% clear cell and 4.5% papillary in Latino adults. In multivariable analysis, non-Latino Black individuals had a higher likelihood of presenting with papillary (OR, 3.99; 95% confidence interval, 3.61–4.42) and chromophobe (OR, 1.81; 1.54–2.13) versus clear-cell subtype compared with non-Latino White individuals. Both hypertension (OR, 1.19; 1.10–1.29) and kidney disease (OR, 2.38; 2.04–2.77 end-stage disease; OR, 1.52; 1.33–1.72 non–end-stage disease) were associated with papillary subtype. Diabetes was inversely associated with both papillary (OR, 0.63; 0.58–0.69) and chromophobe (OR, 0.61; 0.54–0.70) subtypes.

Conclusions:
RCC subtype is independently associated with patient demographics, and comorbidity.

Impact:
Targeted RCC treatments or RCC prevention efforts may have differential impact across population subgroups.
DNA-Dependent Protein Kinase Mediates YB-1 (Y-Box Binding Protein)-Induced Double Strand Break Repair
Authors: Nöthen Till , Sarabi Mohsen Abdi , Weinert Sönke , Zuschratter Werner , Morgenroth Ronnie , Mertens Peter R. , Braun-Dullaeus Ruediger C. , Medunjanin Senad 
Published: December 2022

Background:
DNA-PK (DNA-dependent protein kinase) is a stress-activated serine/threonine kinase that plays a central role in vascular smooth muscle cell proliferation and vascular proliferative disease processes such as neointimal formation. In this study, we link the activation of DNA-PK to the function of the transcription factor YB-1 (Y-box binding protein).

Methods:
To identify YB-1 phosphorylation by DNA-PK, we generated different YB-1-expressing vectors. YB-1 nuclear translocation was investigated using immunoblotting and immunofluorescence staining. For YB-1 activity, luciferase assays were performed.

Results:
We show by mutational analysis and kinase assay that the transcriptional regulator YB-1 is a substrate of DNA-PK. Blockade of DNA-PK by specific inhibitors revealed its critical involvement in YB-1phosphorylation as demonstrated by inhibition of an overexpressed YB-1 reporter construct. Using DNA-PK-deficient cells, we demonstrate that the shuttling of YB-1 from the cytoplasm to the nucleus is dependent on DNA-PK and that the N-terminal domain of YB-1 is phosphorylated at threonine 89. Point mutation of YB-1 at this residue abrogated the translocation of YB-1 into the nucleus. The phosphorylation of YB-1 by DNA-PK increased cellular DNA repair after exposure to ionizing radiation. Atherosclerotic tissue specimens were analyzed by immunohistochemistry. The DNA-PK subunits and YB-1 phosphorylated at T89 were found colocalized suggesting their in vivo interaction. In mice, the local application of the specific DNA-PK inhibitor NU7026 via thermosensitive Pluronic F-127 gel around dilated arteries significantly reduced the phosphorylation of YB-1.

Conclusions:
DNA-PK directly phosphorylates YB-1 and, this way, modulates YB-1 function. This interaction could be demonstrated in vivo, and colocalization in human atherosclerotic plaques suggests clinical relevance of our finding. Phosphorylation of YB-1 by DNA-PK may represent a novel mechanism governing atherosclerotic plaque progression.
Piper&nbsp;puerense, a new species of Piperaceae from Yunnan, China
Authors: SU FAN , JI XUN-ZHI , WU BAO-DUO , QIN XIAO-WEI , HAO CHAO-YUN 
Published: December 2022

Piper puerense (Piperaceae), a new species from Yunnan, China, is here described and illustrated. Detailed morphological comparisons between the newly discovered species and other members of Piper indicate that Piper puerense is similar to Piper curtipedunculum, from which it differs in that stems of the new species are densely pubescent when young, glabrous when mature, leaf blades ovate, 8.5–12 cm × 4.3–6.5 cm, spike peduncle 15 mm long, nearly two times larger than the petiole; female inflorescence 12–18 cm long, male inflorescence 20–30 cm long, fruit obovate in shape, 1.0–1.5 mm in diameter.