bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Approach for Multiple Material Extrusion in Arthroscopic Knee Surgery
Authors: Mazzocchi Tommaso , Guarnera Daniele , Trucco Diego , Restaino Francesco Rocco , Vannozzi Lorenzo , Siliberto Alessio , Lisignoli Gina , Zaffagnini Stefano , Russo Alessandro , Ricotti Leonardo 
Published: September 2022

AbstractArticular cartilage defects and degenerative diseases are pathological conditions that cause pain and the progressive loss of joint functionalities. The most severe cases are treated through partial or complete joint replacement with prostheses, even if the interest in cartilage regeneration and re-growth methods is steadily increasing. These methods consist of the targeted deposition of biomaterials. Only a few tools have been developed so far for performing these procedures in a minimally invasive way. This work presents an innovative device for the direct deposition of multiple biomaterials in an arthroscopic scenario. The tool is easily handleable and allows the extrusion of three different materials simultaneously. It is also equipped with a flexible tip to reach remote areas of the damaged cartilage. Three channels are arranged coaxially and a spring-based dip-coating approach allows the fabrication and assembly of a bendable polymeric tip. Experimental tests were performed to characterize the tip, showing the ability to bend it up to 90° (using a force of ~ 1.5 N) and to extrude three coaxial biomaterials at the same time with both tip straight and tip fully bent. Rheometric analysis and fluid-dynamic computational simulations were performed to analyze the fluids’ behavior; the maximum shear stresses were observed in correspondence to the distal tip and the channel convergence chamber, but with values up to ~ 1.2 kPa, compatible with a safe extrusion of biomaterials, even laden with cells. The cells viability was assessed after the extrusion with Live/Dead assay, confirming the safety of the extrusion procedures. Finally, the tool was tested arthroscopically in a cadaveric knee, demonstrating its ability to deliver the biomaterial in different areas, even ones that are typically hard-to-reach with traditional tools.
Intentional- but not Unintentional Medication Non-adherence was Related with Beliefs about Medicines Among a Multi-Ethnic Sample of People with HIV
Authors: Castelan Anjuly , Nellen Jeannine F , van der Valk Marc , Nieuwkerk Pythia T 
Published: September 2022

AbstractMedication non-adherence can be intentional or unintentional. We investigated the prevalence of unintentional and intentional non-adherence to antiretroviral therapy (ART) and the relationship with beliefs about medicines, sociodemographic- and HIV-related variables among people with HIV (PWH) attending the HIV clinic of the Amsterdam University Medical Centers. Participants completed the Medication Adherence Rating Scale (MARS) and the Beliefs about Medicines (BMQ) questionnaire. About half of 80 participants reported unintentional non-adherence and 20% reported intentional non-adherence. Both unintentional and intentional non-adherence were associated with younger age. Additionally, intentional non-adherence was associated with being a migrant from Suriname /Netherlands Antilles, having more concerns about negative effects of ART and stronger beliefs that medicines in general are overused/ overprescribed. In conclusion, intentional but not unintentional non-adherence was associated with beliefs about medicines. Eliciting and discussing beliefs about medicines may be a promising avenue to address patients’ concerns and perceptions thereby potentially enhancing medication adherence.
Comparative Effectiveness of Integrated Peer Support and Clinical Staffing Models for Community-Based Residential Mental Health Rehabilitation: A Prospective Observational Study
Authors: Parker Stephen , Arnautovska U. , Korman N. , Harris M. , Dark F. 
Published: September 2022

AbstractThis observational study compared the outcomes of consumers receiving community-based residential mental health rehabilitation support in Australia under a clinical staffing model and an integrated staffing model where Peer Support Workers are the majority component of the staffing profile. Reliable and clinically significant (RCS) change between admission and discharge in functional and clinical assessment measures were compared for consumers receiving care under the clinical (n = 52) and integrated (n = 93) staffing models. Covariate analyses examined the impact of known confounders on the outcomes of the staffing model groups. No statistically significant differences in RCS improvement were identified between the staffing models. However, logistic regression modelling showed that consumers admitted under the integrated staffing model were more likely to experience reliable improvement in general psychiatric symptoms and social functioning. The findings support the clinical and integrated staffing models achieving at least equivalent outcomes for community-based residential rehabilitation services consumers.
Identifying potential causal effects of age at menopause: a Mendelian randomization phenome-wide association study
Authors: Magnus Maria C. , Borges Maria Carolina , Fraser Abigail , Lawlor Deborah A. 
Published: September 2022

AbstractAge at natural menopause (ANM) is associated with a range of health-related traits, including bone health, female reproductive cancers, and cardiometabolic health. Our objective was to conduct a Mendelian randomization phenome-wide association study (MR-pheWAS) of ANM. We conducted a hypothesis-free analysis of the genetic risk score (GRS) for ANM with 18,961 health-related traits among 181,279 women in UK Biobank. We also stratified the GRS according to the involvement of SNPs in DNA damage response. We sought to replicate our findings in independent cohorts. We conducted a negative control MR-pheWAS among men. Among women, we identified potential effects of ANM on 221 traits (1.17% of all traits) at a false discovery rate (P value ≤ 5.83 × 10–4), and 91 (0.48%) potential effects when using Bonferroni threshold (P value ≤ 2.64 × 10–6). Our findings included 55 traits directly related to ANM (e.g. hormone replacement therapy, gynaecological conditions and menstrual conditions), and liver function, kidney function, lung function, blood-cell composition, breast cancer and bone and cardiometabolic health. Replication analyses confirmed that younger ANM was associated with HbA1c (adjusted mean difference 0.003 mmol/mol; 95% CI 0.001, 0.006 per year decrease in ANM), breast cancer (adjusted OR 0.96; 95% CI 0.95, 0.98), and bone-mineral density (adjusted mean difference − 0.05; 95% CI − 0.07, − 0.03 for lumbar spine). In men, 30 traits were associated with the GRS at a false discovery rate (P value ≤ 5.49 × 10–6), and 11 potential effects when using Bonferroni threshold (P value ≤ 2.75 × 10–6). In conclusion, our results suggest that younger ANM has potential causal effects on a range of health-related traits.
Performance and evolutionary adaptation of heterogeneous wheat populations
Authors: Baresel Jörg Peter , Bülow Lorenz , Finckh Maria Renate , Frese Lothar , Knapp Samuel , Schmidhalter Urs , Weedon Odette 
Published: September 2022

AbstractThe aim of this study was to investigate the potential of heterogeneous composite cross populations (CCPs) to increase sustainability and resilience of wheat cropping systems, a so far largely neglected approach. For this purpose, 10 CCPs originating from one CCP created in 2001 and having evolved under different environmental conditions since the F5, were compared in the F15 and F16 with 10 recently released cultivars and 10 inbred lines extracted randomly from the populations. Field trials were performed over 2 years at 2 organic and 2 conventional locations. Under organic conditions, yields of the CCPs were similar to those of recent commercial cultivars with comparable protein content, and considerably higher than that of the inbred lines. Under conventional conditions, conventionally-bred cultivars outyielded the other experimental entries. The organically-bred cultivars had the highest protein contents in both farming systems followed by the CCPs and the conventionally-bred cultivars. The yield stability and foliar disease resistances of CCPs was on average higher than that of the commercial cultivars and considerably higher than that of the inbred lines, indicating that the higher stability of the CCPs was due to their high genetic diversity, not to their genetic background. CCPs that had evolved in different environments differed in some morphological and phenological traits, indicating that adaptation to environmental conditions had taken place through natural selection. Greater tillering capacity and increased soil cover of CCPs in the juvenile stage compared to the inbred lines indicates niche complementarity in the CCPs, that may contribute to improved resource use and to an overall ecological intensification. We conclude, that the cultivation of CCPs or similar heterogeneous populations represents an important opportunity to increase the resilience of wheat cultivation, which should be given greater consideration in future research and breeding.
Attitudes toward global and national climate policies in Finland – The significance of climate change risk perception and urban/rural-domicile
Authors: Sivonen Jukka 
Published: September 2022

AbstractThis paper examines public support for global- and national-level climate policy instruments in Finland, and the ways urban/rural-domicile and climate change risk perception predict people’s attitudes toward climate policies. Moreover, this study analyzes the degree to which perception of closeness to the district modifies people’s climate policy attitudes. The research method employed was ordinal logistic regression and data were from the demographically representative Finland 2019-survey (n = 1742 and response activity = 44%). According to the results, subsidizing renewable energy is an especially popular climate policy instrument, whereas approving new nuclear plants is rather unpopular. Policy instruments were typically more popular at the global level than they were at the national level. Perception of climate change risk was especially strongly linked with support for a national carbon tax. The effect of urban/rural-domicile and subjective closeness to the district on the attitudes was highly dependent on the policy instrument in question. The study contributes to the understanding of how climate policy attitudes vary depending on the climate change risk perception, urban/rural-domicile, and the instrument-type.
Developing food waste biorefinery: using optimized inclined thin layer pond to overcome constraints of microalgal biomass production on food waste digestate
Authors: Chuka-ogwude David , Mickan Bede S. , Ogbonna James C. , Moheimani Navid R. 
Published: September 2022

AbstractDiversion of food waste from landfill through anaerobic digestion is a sustainable form of energy production (biogas) and the waste effluent (digestate) can be utilised as nutrient supply for microalgae cultivation. However, digestate has very high nutrient concentrations and is highly turbid, making it difficult to utilize as a nutrient source with conventional microalgae cultivation systems. Here we compared the efficiencies of a conventional open raceway pond (ORWP) and an improved inclined thin layer photobioreactor (ITLP) for the utilization and treatment of food waste derived digestate by Chlorella sp. The ITLP improved on volumetric and areal productivities by 17 and 3 times over the ORWP, with values of 0.563 and 31.916 g m −2 day −1 respectively. Areal nutrient removal via microalgae biomass were 2359.759 ± 64.75 and 260.815 ± 7.16 mg m −2 day −1 for nitrogen and phosphorous respectively in the ITLP, which are 2.8 times higher than obtained in the ORWP. The ITLP’s superiority stems from its ability to support a much higher average biomass yield of 6.807 g L −1, which was 7 times higher than in the ORWP. Mean irradiance in-situ was higher in the ITLP, irradiance distribution and utilization by the culture in the ITLP was 44% more efficient than in the ORWP. Our results indicate that the ITLP is a far more productive system than conventional raceway ponds. This demonstrates that integration of ITLP microalgae cultivation using digestate has the potential to make digestate management yield net benefit in food waste biorefinery settings.
Dopamine as a bioinspired adhesion promoter for the metallization of multi-responsive phase change microcapsules
Authors: Zimmerer Cordelia , Fredi Giulia , Putzke Sascha , Boldt Regine , Janke Andreas , Krause Beate , Drechsler Astrid , Simon Frank 
Published: September 2022

AbstractThis work reports on an environmentally friendly method to produce encapsulated phase change material with a thin nickel coating, applicable for heat conversion, storage and thermal management of heat-sensitive components and suitable for active heating by electromagnetic radiation. A critical issue for the metallization is the adhesion between the polymer capsule shell and the metal layer. Based on previous studies using the bio-molecule dopamine as adhesion promoter in composites and for plastics metallization, commercial paraffin microcapsules were coated with an ultrathin polydopamine film via a simple wet chemical process. Subsequently, a thin, uniform and compact nickel layer was produced by electroless metallization. The successful deposition of both layers was verified with a broad range of imaging and spectroscopic techniques. For the first time, surface-enhanced IR spectroscopy was used to study the deposition of ultrathin PDA films. The combination of SEM and energy-dispersive X-ray spectroscopy allowed resolving the spatial distribution of the elements Ni, N, and O in the MC shell. Electrically conducting paths in the Ni shell were verified by conductive AFM. Thermal analysis revealed that the coated microcapsules show a phase change enthalpy of approx. 170 J/g, suitable for thermal storage and management. Additionally, the nickel layer enhanced the thermal diffusivity of the microcapsule powders and enables a fast heating of the PCM microcapsules by microwave radiation, demonstrating the applicability of the metallized MCs for controlled heating applications.
Graphical abstract
Systematic Review and Meta-Analysis of the Effectiveness of Teacher Delivered Interventions for Externalizing Behaviors
Authors: Aldabbagh R. , Glazebrook C. , Sayal K. , Daley D. 
Published: September 2022

AbstractThis systematic review and meta-analysis explores the effectiveness of teacher interventions supporting children with externalizing behaviors based on teacher and child outcomes. A systematic search was conducted using 5 electronic databases. From 5714 papers, 31 papers that included interventions delivered directly to teachers and aimed to benefit either teachers and/or children with externalizing behaviors were included. The review focused on qualified teachers working with children aged 2–13. The results of the current meta-analysis revealed a positive effect of teacher intervention on teacher and child outcomes, including the increased use of teacher-appropriate strategies, as well as significant and moderate improvements in teacher–child closeness, and small reductions in teacher–child conflict. For child outcomes, the interventions reduced externalizing behavior problems and ADHD symptoms and enhanced prosocial behavior. Only one fully blinded analysis for conduct problems was possible and revealed a moderate but significant reduction in favor of intervention. These findings provide evidence to support the role of teacher interventions for both teachers and children with externalizing behaviors. Future research should include more PBLIND measurements so that MPROX findings can be confirmed. More research should be done to evaluate the influence of teacher interventions on teachers’ well-being.
Ecological impacts of N-deposition in a remote, high-elevation lake in the Three River Headwaters Region, Qinghai-Tibetan Plateau
Authors: Luo Yuxin , Taylor Karen J. , Potito Aaron P. , Molloy Karen , Beilman David W. , Tang Ya 
Published: September 2022

AbstractThis study provides a new record of nitrogen (N) deposition and ecological response at a remote, high-elevation lake within the ecologically fragile Three River Headwaters Region, northwest China, from the early 20thCentury to the past decade. A multi-proxy investigation of a lake sediment core including analyses of chironomids (non-biting midge), lake sediment geochemistry (δ15N, δ13C, TN, TOC, OC:TN), pollen, non-pollen palynomorphs and 210Pb-dating. Results were compared with regional pollution forcings, including fertiliser application, atmospheric nitrate and dust deposition, and a localised multiscale air quality modelling system for N-deposition. Our data reflect a mesotrophic lake for the majority of the 20th Century with minimal anthropogenic impact. A shift in the lake conditions is evident after 1985 with increased nutrient enrichment. Low δ15N, OC:TN and increasing TN values, together with an increase in chironomid taxa associated with eutrophic conditions and macrophytes are exhibited in the record, particularly since 2002. These changes are consistent with nutrient loading causing a change in trophic status. Redundancy analysis (RDA) and partial RDAs verified TN as an important driver behind the shift in chironomid community composition in recent decades, explaining 22.2% of the variance on its own and 16.9% with other environmental variables partialled out. While temperature change since 1960 was not a primary control on the chironomid community of Lake Bander, a step-change increase in summer temperatures since the 1990s coincided with the disappearance of cold stenotherms from the record and seems to have exacerbated the shift to more productive conditions. This study highlights the reach of airborne N from modern agricultural and industrial activity to remote locations, and demonstrates the utility of palaeolimnological techniques as part of modern ecosystem assessment for conservation.
Self-similar analysis of the time-dependent compressible and incompressible boundary layers including heat conduction
Authors: Barna Imre Ferenc , Bognár Gabriella , Mátyás László , Hriczó Krisztián 
Published: September 2022

AbstractWe investigate the incompressible and compressible heat conducting boundary layer with applying the two-dimensional self-similar Ansatz. Analytic solutions can be found for the incompressible case which can be expressed with special functions. The parameter dependencies are studied and discussed in details. In the last part of our study we present the ordinary differential equation (ODE) system which is obtained for compressible boundary layers.
Nonlinear steady state vibrations of beams made of the fractional Zener material using an exponential version of the harmonic balance method
Authors: Lewandowski Roman 
Published: September 2022

AbstractThis paper presents the application of an exponential version of the harmonic balance method to the analysis of steady state vibration of geometrically nonlinear systems. A detailed description of the method and of the corresponding numerical procedure is provided. The von Karman theory is used to describe the effects of geometric nonlinearity. The material of the beams is modelled with the help of the Zener model using the fractional calculus. The problem is solved using an exponential version of the harmonic balance method. In the above-mentioned version, the complex calculus is used in contrast to the ordinary harmonic balance method, where the steady state vibrations are described with the help of the trigonometric functions. It significantly simplifies derivation of the amplitude equations. Moreover, the exponential version of the harmonic balance method is more elegant in comparison with the ordinary one. A detailed derivation of the amplitude equations is presented. The modified continuation method is proposed to solve the nonlinear amplitude equations and to determine the response curves. Moreover, the results of the exemplary calculation are presented and compared with known results in order to justify the efficiency and the correctness of the proposed approach.
A Prospective Cohort Study of Changes in Access to Contraceptive Care and Use Two Years after Iowa Medicaid Coverage Restrictions at Abortion-Providing Facilities Went into Effect
Authors: Kavanaugh Megan L. , Zolna Mia , Pliskin Emma , MacFarlane Katrina 
Published: September 2022

AbstractInequities in access to contraception based on ability to pay can interfere with individuals’ reproductive autonomy. This study examines the impact of a 2017 state-level policy in Iowa restricting Medicaid coverage at abortion-providing health care centers on patients’ access to contraceptive care and subsequent contraceptive use. We draw on a unique panel dataset of individuals who originally sought care at a publicly supported family planning site in Iowa in 2018–2019 and then participated in subsequent follow-up surveys every 6 months for 2 years to examine an effect of access to care on contraceptive use. Among our final analytic sample of 368 individuals, our findings indicate that receipt of recent contraceptive care decreased over the study period; this coincided with patients shifting away from getting contraceptive care at sites potentially impacted by the 2017 Iowa Medicaid policy restriction while those getting this care at non-impacted sites remained relatively steady over the study period. At the same time, nonuse of contraception increased while use of a contraceptive method that carries cost, use of a provider-involved method, and satisfaction with one’s method decreased. We find that, after controlling for patient characteristics, those who shifted toward receiving contraceptive care experienced increases in these three contraceptive outcomes. We interpret this as preliminary descriptive evidence demonstrating an impact of disruptions in access to contraceptive care on contraceptive outcomes. Supportive payment and funding strategies for contraception, rather than policies that impede or restrict access, are needed to enable people to realize full reproductive autonomy.