bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age-Independent Preoperative Chemosensitivity and 5-Year Outcome Determined by Combined 70- and 80-Gene Signature in a Prospective Trial in Early-Stage Breast Cancer
Authors: Whitworth Pat , Beitsch Peter D. , Pellicane James V. , Baron Paul L. , Lee Laura A. , Dul Carrie L. , Nash Charles H. , Murray Mary K. , Richards Paul D. , Gittleman Mark , Budway Raye , Rahman Rakhshanda Layeequr , Kelemen Pond , Dooley William C. , Rock David T. , Cowan Ken , Lesnikoski Beth-Ann , Barone Julie L. , Ashikari Andrew Y. , Dupree Beth , Wang Shiyu , Menicucci Andrea R. , Yoder Erin B. , Finn Christine , Corcoran Kate , Blumencranz Lisa E. , Audeh William ,   NBRST Investigators Group
Published: April 2022

Abstract
Background
The Neoadjuvant Breast Symphony Trial (NBRST) demonstrated the 70-gene risk of distant recurrence signature, MammaPrint, and the 80-gene molecular subtyping signature, BluePrint, precisely determined preoperative pathological complete response (pCR) in breast cancer patients. We report 5-year follow-up results in addition to an exploratory analysis by age and menopausal status.

Methods
The observational, prospective NBRST (NCT01479101) included 954 early-stage breast cancer patients aged 18–90 years who received neoadjuvant chemotherapy and had clinical and genomic data available. Chemosensitivity and 5-year distant metastasis-free survival (DMFS) and overall survival (OS) were assessed. In a post hoc subanalysis, results were stratified by age (≤ 50 vs. > 50 years) and menopausal status in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2−) tumors.

Results
MammaPrint and BluePrint further classified 23% of tumors to a different subtype compared with immunohistochemistry, with more precise correspondence to pCR rates. Five-year DMFS and OS were highest in MammaPrint Low Risk, Luminal A-type and HER2-type tumors, and lowest in MammaPrint High Risk, Luminal B-type and Basal-type tumors. There was no significant difference in chemosensitivity between younger and older patients with Low-Risk (2.2% vs. 3.8%; p = 0.64) or High-Risk tumors (14.5% vs. 11.5%; p = 0.42), or within each BluePrint subtype; this was similar when stratifying by menopausal status. The 5-year outcomes were comparable by age or menopausal status for each molecular subtype.

Conclusion
Intrinsic preoperative chemosensitivity and long-term outcomes were precisely determined by BluePrint and MammaPrint regardless of patient age, supporting the utility of these assays to inform treatment and surgical decisions in early-stage breast cancer.
Novel behavioral model in evaluating initiation and sustenance of teeth brushing behavior among students pursuing health sciences: a cross-sectional study
Authors: Panjwani Dhiraj , Pai Mithun , Yellapurkar Shweta , Poddar Aayush Anand , Rajesh Gururagavendra 
Published: April 2022

Background: Oral hygiene maintenance is a crucial and integral feature in determining the overall wellbeing of a person. It has been established that interventions for health promotion at the public health level derived from theoretical models based on social and behavioural sciences have a superior effectiveness as compared to the ones without a theoretical background. Hence a novel behavioral model known as the multi-theory model (MTM) was used to understand two important aspects of health behavior change: (i) Initiation and (ii) Sustenance in twice daily teeth brushing in a university setting with objectives to identify factors effecting MTM in initiation and sustenance of twice daily brushing behavior among students pursuing health sciences and correlating the MTM theory with socio-demographic and behavioral patterns. Methods: The study is an analytical cross-sectional study. Students pursuing Medicine and Dentistry in a University setting were included. A validated questionnaire was designed for this study. Questions were framed to evaluate the constructs of initiation and sustenance of MTM, personality, sleeping habits and demographic corelates of participants. Multiple means between the groups were compared using analysis of variance and a post hoc test. Correlation was established between different domains, the items were then entered for hierarchical multiple regression. Results: Of the 235 participants in the study, 229 completed the questionnaire. There was a significant association between brushing quartiles, professional streams (p<0.001) and academic performance (p<0.001). The hierarchical multiple regression revealed that at stage one, behavioral confidence contributed significantly to the regression model (F (1,227) = 33.227, p<0.001) and accounted for 12.4% of the variation in twice daily brushing. Conclusion: MTM is a good tool in predicting the initiation and sustenance of twice daily brushing behavior among young adults and can form a useful tool in assessing the patterns of brushing behavior in a population.
Case Report: Identification of likely recurrent CEP290 mutation in a child with Joubert syndrome and cerebello-retinal-renal features.
Authors: Spahiu Lidvana , Sayer John A , Behluli Emir , Liehr Thomas , Temaj Gazmend 
Published: April 2022

Background. Joubert syndrome (JS) is a rare autosomal recessive ciliopathy with an estimated prevalence of 1 in 100,000. JS is characterized by hyperpnoea, hypotonia, ataxia, developmental delay and various neuropathological abnormalities in the brain including cerebellar hypoplasia and cerebellar vermis aplasia. JS can also have variable multi-organ involvement, including the retina, kidneys, liver, and musculoskeletal system. Methods and Results. Here we report a clinical description of two-year-old girl presenting with breathing difficulties, hyperechoic kidneys with loss of corticomedullary differentiation. Brain magnetic resonance imaging revealed the typical molar tooth sign consistent with a clinical diagnosis of JS and retinal examination showed severe retinal dystrophy leading to blindness. Molecular genetic analysis using whole exome sequencing and Sanger sequence confirmation demonstrated a homozygous mutation (c.5493delA, p.(A1832fs*19) in CEP290 which segregated from either parent and was consistent with the multisystem ciliopathy phenotype. This precise variant has been described previously in 2 families from the Kosovar-Albanian region suggesting this allele is a recurrent mutation in this population. Conclusions. Mutations in CEP290 lead to multisystem ciliopathy syndromes and molecular genetic diagnostics of such cases allows precise diagnosis, screening of at risk relatives and appropriate management.
Evaluation of the rapid, multi-country, parallel process, multi-tasking approach to startup of short-term technical assistance to improve service delivery in newborn and child health in the context of USAID’s Zika response in four Eastern and Southern Caribbean countries
Authors: Aumakhan Bulbul , Coly Astou , Hager Salwan , Chitashvili Tamar , Massoud M. Rashad 
Published: April 2022

Background: In 2018, the USAID Applying Science to Strengthen and Improve Systems (ASSIST) Project started a new partnership with four Eastern and Southern Caribbean countries impacted by the Zika virus: Antigua and Barbuda, Dominica, St. Kitts and Nevis, and St. Vincent and the Grenadines. The goal of the project was to provide short-term technical assistance (STTA) to strengthen the health systems’ capacity to detect newborns and young children potentially affected by Zika and to address their health needs. To meet these objectives, ASSIST developed an innovative approach based on its existing model for service delivery improvement. This novel approach is known as Rapid, Multi-country, Parallel Process, Multi-tasking Approach for a Project Startup (RMPP-MAPS). An evaluation was conducted to document the STTA startup activities, to identify enabling and constraining factors, and to capture lessons learned. Methods: An external consultant conducted remote in-depth interviews with individuals involved in the startup using semi-structured interview guides and retrieved data from the review of project documents. Results: Using RMPP-MAPS, the ASSIST Project successfully implemented the startup for complex STTA in four countries within less than four months, spanning mid-May to early September 2018. Project milestones included achieving buy-in from stakeholders, co-developing the technical scope and materials, and rapidly executing critical operational functions. Dedicated project teams, country leaderships, and local champions were essential to overcoming the main challenges, which included a condensed timeframe, lack of in-country offices, and country-level factors such as a shortage of health care workers and a weak health infrastructure. Conclusions: The RMPP-MAPS is a feasible and resource-efficient mechanism of interest to implementers, donors, and low and middle-income countries facing temporal and financial limitations to rapidly addressing public health priorities.
Asymptomatic COVID-19 in the elderly: dementia and viral clearance as risk factors for disease progression.
Authors: Esteban Ignacio , Bergero Georgina , Alves Camila , Bronstein Micaela , Ziegler Valeria , Wood Cristian , Caballero Mauricio T. , Wappner Diego , Libster Romina , Perez Marc Gonzalo , Polack Fernando P. 
Published: April 2022

Background: SARS-CoV-2 infected individuals ≥60 years old have the highest hospitalization rates and represent >80% fatalities. Within this population, those in long-term facilities represent >50% of the total COVID-19 related deaths per country. Among those without symptoms, the rate of pre-symptomatic illness is unclear, and potential predictors of progression for symptom development are unknown. Our objective was to delineate the natural evolution of asymptomatic SARS-CoV-2 infection in elders and identify determinants of progression. Methods: We established a medical surveillance team monitoring 63 geriatric institutions in Buenos Aires, Argentina during June-July 2020. When an index COVID-19 case emerged, we tested all other eligible asymptomatic elders ≥75 or >60 years old with at least 1 comorbidity. SARS-CoV-2 infected elders were followed for 28 days. Disease was diagnosed when any COVID-19 manifestation occurred. SARS-CoV-2 load at enrollment, shedding on day 15, and antibody responses were also studied. Results: After 28 days of follow-up, 74/113(65%) SARS-CoV-2-infected elders remained asymptomatic. 54% of pre-symptomatic patients developed hypoxemia and ten pre-symptomatic patients died. Dementia was the only clinical risk factor associated with disease(OR 2.41(95%CI=1.08, 5.39). In a multivariable logistic regression model, dementia remained as risk factor for COVID-19 severe disease. Furthermore, dementia status showed a statistically significant different trend when assessing the cumulative probability of developing COVID-19 symptoms(log-rank p=0.027). On day 15, SARS-CoV-2 was detectable in 30% of the asymptomatic group while in 61% of the pre-symptomatic(p=0.012). No differences were observed among groups in RT-PCR mean cycle threshold at enrollment(p=0.391) and in the rates of antibody seropositivity(IgM and IgG against SARS-CoV-2). Conclusions: In summary, 2/3 of our cohort of SARS-CoV-2 infected elders from vulnerable communities in Argentina remained asymptomatic after 28 days of follow-up with high mortality among those developing symptoms. Dementia and persistent SARS-CoV-2 shedding were associated with progression from asymptomatic to symptomatic infection.
COVID-19 IDD: Findings from a global survey exploring family members’ and paid staff’s perceptions of the impact of COVID-19 on individuals with intellectual and developmental disabilities (IDD) and their caregivers.
Authors: Linehan Christine , Birkbeck Gail , Araten-Bergman Tal , Baumbusch Jennifer , Beadle-Brown Julie , Bigby Christine , Bradley Valerie , Brown Michael , Bredewold Femmianne , Chirwa Masauso , Cui Jialiang , Godoy Gimenez Marta , Gomeiro Tiziano , Kanova Šárka , Kroll Thilo , Li Henan , MacLachlan Mac , Narayan Jayanthi , Nearchou Finiki , Nolan Adam , O'Donovan Mary-Ann , Santos Flavia H , Šiška Jan , Stainton Tim , Tideman Magnus , Tossebro Jan 
Published: April 2022

Background: A growing body of evidence attests to the disproportionate impact of COVID-19 on persons with intellectual and developmental disabilities (IDD) during the pandemic. This study asked caregivers about their perceptions of how COVID-19 impacted them and the people they support. Method: An online survey was conducted in 12 countries during August-September 2020 and sought information on demographics, support practices, information and training, experiences of COVID-19, social distancing, and wellbeing, as measured by the DASS12. This study reports on 3,754 family members, direct support professionals, and managers who participated in the survey. Results: Caregivers observed increases in depression/anxiety, stereotyped behaviours, aggression towards others and weight gain in the person(s) they supported. They also reported difficulties supporting the person(s) to access healthcare. Families reported reducing or ceasing employment and absorbed additional costs when supporting their family member. Direct support professionals experienced changes in staff shifts, staff absences, increased workload and hiring of casual staff. Caregivers’ wellbeing revealed high levels of stress, depression, and less so anxiety. The strongest predictor of wellbeing among families was observation of changes in mood in the person(s) they supported, while for direct support professionals, the strongest predictors of wellbeing were reorganisation of staff shifts and increases in new direct support staff. Discussion: Findings support the contention of this population experiencing a disproportionate burden during the COVID-19 pandemic, reflecting historical inequities in access to healthcare and other human rights violations which are now protected under the United Nations Convention on the Rights of Persons with Disabilities.
COVID-19 pandemic in Ireland: Epidemiology, public health restrictions and vaccination uptake
Authors: Kelly David M , Stamenic Danko , Mullane Paul , Ni Bhuachalla Cliodhna , Conway Robert , Carroll Ciara , O'Connor Lois , Doyle Sarah M , Buckley Claire M , Kearney Patricia M 
Published: April 2022

Background: The first wave of COVID-19 pandemic in Ireland was managed by a prolonged national lockdown. The second and third waves were managed by continued non-pharmaceutical interventions (NPIs) and deployment of a national vaccination programme. This paper aims to describe the epidemiological trends, Public Health restrictions and vaccination uptake during the first three waves of the pandemic. Methods: Data on confirmed cases of COVID-19 from 1 March 2020 to 27 March 2021 were extracted from the national COVID-19 data hub, the Health Protection Surveillance Centre (HPSC) and the National Contact Management Programme. Vaccine uptake and epidemiological data from European Centre for Disease Prevention and Control were reported from four other EU states. Results: Ireland experienced three distinct waves of COVID-19; first wave occurred March to August 2020, second August to November 2020 and third from November 2020 onwards. The third wave was attributable to emergence of the Alpha variant of concern (B.1.1.7 strain) and relaxation of public health restrictions in December 2020, when weekly mean number of close contacts per case peaked at 5.2. A similar epidemiological trajectory was observed across four other EU states. Conclusions: Surges of COVID-19 continue to occur despite increasing vaccine coverage in the EU, due to the emergence of novel variants of concern and relaxation of Public Health restrictions. A “vaccine plus policy” is needed.
Contrast discrimination in images of natural scenes
Authors: Jarvis John , Triantaphillidou Sophie , Gupta Gaurav 
Published: April 2022

Contrast discrimination determines the threshold contrast required to distinguish between two suprathreshold visual stimuli. It is typically measured using sine-wave gratings. We first present a modification to Barten’s semi-mechanistic contrast discrimination model to account for spatial frequency effects and demonstrate how the model can successfully predict visual thresholds obtained from published classical contrast discrimination studies. Contrast discrimination functions are then measured from images of natural scenes, using a psychophysical paradigm based on that employed in our previous study of contrast detection sensitivity. The proposed discrimination model modification is shown to successfully predict discrimination thresholds for structurally very different types of natural image stimuli. A comparison of results shows that, for normal contrast levels in natural scene viewing, contextual contrast detection and discrimination are approximately the same and almost independent of spatial frequency within the range of 1–20 c/deg. At higher frequencies, both sensitivities decrease in magnitude due to optical limitations of the eye. The results are discussed in relation to current image quality models.
Impact of working from home on European office rents and vacancy rates
Authors: Morawski Jaroslaw 
Published: April 2022

AbstractThe massive shift to working from home during the Covid-19 pandemic triggered discussions about its potential impact on the future demand for office space and the risk it poses to the performance of office markets. Against this background, the goal of this paper is to investigate the link between working from home and the evolution of key indicators of office occupier markets across Europe over the past three decades. Based on the data from Eurostat and CBRE, the paper uses panel regression to investigate the temporal as well as cross-sectional relationships between the share of the workforce working from home and office rents and vacancy rates in major cities. The results are interesting in several ways. Firstly, changes in the share of employees working from home did not appear to have any significant impact on the evolution of rents or vacancy rates over time. However, occasional homeworking was significant in explaining cross-sectional differences in office market indicators. Moreover, contrary to the initial expectations, higher share of employees occasionally working from home appeared to be associated with stronger performance of the respective office market. As explanation, the paper proposes a hypothesis that this was due to working from home being only one aspect of broader changes in the office work environment and related socio-economic trends that had a net beneficial effect on office occupier markets. Although the results refer to historical developments and may not be fully applicable to the current context of the pandemic, they highlight the need to consider working from home in a broader perspective of office occupier trends and ways of working.
Establishment of a no-notice drill mode evaluation system for public health emergencies
Authors: Huang Sicheng , Lin Zibo , Lin Xinqi , Li Lin , Ruan Feng , Mei Wenhua , Chen Sidong 
Published: April 2022

Objective
At present, there are some no-notice drill mode evaluation systems for public health emergencies in Chinese hospitals, which are the subjects of assessment in this study. However, there is a lack of CDC. This study builds a set of no-notice drill mode evaluation systems for public health emergencies that involve the CDC.

Methods
The indexes for these systems were based on the performance of two no-notice drills for public health emergencies in Guangdong Province. Twenty experts were invited to screen the indicators during two rounds of the Delphi method to determine the weight of first- and second-level indexes through the analytic hierarchy process, and the weight of the third-level index was calculated using the percentage method.

Results
After two rounds of expert consultation, we obtained four first-level indicators, twenty-six second-level indicators and eighty-six third-level indicators. According to the weight calculated by analytic hierarchy process, the weights of the first-level indicators are emergency preparation (0.2775), verification and consultation regarding an epidemic situation (0.165), field investigation and control (0.3925) and summary report (0.165). Sensitivity analysis shows that the stability of the index is good.

Conclusion
The no-notice drill mode evaluation system for public health emergencies constructed in this study can be applied to public health departments such as the CDC. Through promotion, it can provide a scientific basis for epidemiological investigation assessment.
Menopause experiences of women according to transition theory
Authors: Güleç Şatır Duygu , Sevil Ümran , Okçay Hale 
Published: April 2022

Aim: This research was aimed to investigate menopausal transition experiences of women according to Meleis’ transition theory.
Method: This research was carried out with 13 postmenopausal women who applied at one Educational and Research Hospital. The participants were chosen with purposive sampling. Person Description Form, SemiPerson description form, and semi structured interview form were used as data collection tools. The interviews conducted with face-to-face in-depth interview method were recorded on tape and transferred to the computer in the written transcript. Data were described and categorized under certain themes after being coded. The data were analyzed with content analysis.
Findings: The mean age of the women included in the study was 54.76±5.18 years, 84.6% of them were primary school graduates, and 76.9% of them were married.
The themes analyzed after the interviews were presented in four areas according to the components of the theory within the framework of Meleis' transition theory. These were Properties of Transitions, Transitions conditions; facilitators, inhibitors, Patterns of Response and Nursing therapeutics.
Conclusions: In light of the results, it was founded that women were aware of the menopause transition. In this period, they experienced physical, mental, and social changes and differences. Although they have negative perceptions about menopause, they have developed coping techniques. In this period, they needed the nursing support.
​Extended English summary is in the end of Full Text PDF (TURKISH) file.

Özet

Amaç: Araştırma, kadınların menopoza geçiş deneyimlerini Meleis’in geçiş teorisine göre incelemek amacıyla yapılmıştır.
Yöntem: Araştırma bir eğitim araştırma hastanesinin jinekoloji polikliniğine başvuran postmenopozal dönemdeki 13 kadınla gerçekleştirilmiştir. Katılımcılar amaçlı örneklem tekniği ile belirlenmiştir. Veriler birey tanılama formu ve yarı yapılandırılmış görüşme formu ile toplanmıştır. Yüz yüze derinlemesine görüşme tekniği ile gerçekleştirilen görüşmeler ses kayıt cihazına kaydedilmiş ve bilgisayar ortamında yazılı döküm haline getirilmiştir. Veriler kodlanıp temalara göre sınıflandırılmıştır. Verilerin analizinde içerik analizi yöntemi kullanılmıştır.
Bulgular: Araştırmaya alınan kadınların yaş ortalaması 54.76±5.18 olup, %84.6’sı ilkokul mezunu ve % 76.9’u evlidir. Görüşmeler sonrası analiz edilen temalar Meleis’in geçiş teorisi çerçevesinde teorinin bileşenlerine göre dört alanda sunulmuştur. Bu alanlar; geçiş özellikleri, geçiş sürecini kolaylaştıran ya da önleyen koşullar, yanıt şekilleri ve terapötik hemşireliktir.
Sonuç: Araştırma sonucunda kadınların menopoza geçiş deneyiminin farkında olduğu ve bu süreçte fiziksel, psikolojik ve sosyal değişim ve farklılıklar yaşadıkları saptanmıştır. Kadınlar menopoza yönelik olumsuz algılara sahip olmakla birlikte bu süreçte menopozla başetme teknikleri geliştirmişlerdir. Bu dönemde hemşirelik desteğine ihtiyaç duymuşlardır.