bluuebunny/crossref_metadata_2025_split huggingface dataset:
A clinicopathological and immunophenotypic study of nodal Hodgkin’s lymphomas
Authors: Moras Christol , Rout Pritilata 
Published: November 2022

Introduction and Aim: Hodgkin’s lymphoma is a B cell lymphoma, the diagnosis of which is characterized by the presence of neoplastic Hodgkin’s/Reed Sternberg cells (HRS) and the unique cellular microenvironment. Clinical examinations, morphology and immunophenotypic study aids in the accurate diagnosis of Hodgkin’s lymphoma (HL). The literature available on the clinicopathological and immunohistochemistry (IHC) profile of Hodgkin’s lymphoma in Indian population is inadequate. This study was carried out to describe the clinicopathological and immunohistochemical profile of patients in an Indian tertiary care hospital.

Methodology: An observational, descriptive study was carried out and included all diagnosed cases of nodal HL for a period of 4 and half years. The demographic details and common clinical presentation were retrieved from the records. The Haematoxylin and eosin (H and E) slides and IHC stained slides for CD15, CD30, CD20, LCA and CD3 were retrieved and studied. Each case was assigned to one of the following histological subtypes. mixed cellularity (MC), nodular sclerosis (NS), lymphocyte rich (LR), lymphocyte depleted (LD) and nodular lymphocyte predominant Hodgkin’s lymphoma (NLPHL). Those cases where histological subtyping could not be done due to equivocal features were grouped as unclassifiable.

Results: A total number of 65 cases of Hodgkin’s lymphoma were included. A unimodal distribution and male preponderance was noted. The subtype of Mixed cellularity predominated the series followed by nodular sclerosis, lymphocyte rich and lymphocyte depleted. There was only one case of Nodular Lymphocyte Predominant Hodgkin’s lymphoma. Immunoreactivity of CD 30 was seen in all cases of classical Hodgkin’s Lymphoma.

Conclusion: Our study reaffirms the findings from previous research ,highlighting the difference in clinicopathological profile of HL from its western counterpart. The usage of immunohistochemistry should be done for all cases of HL since it aids in the diagnosis and also in identification of potential therapeutic targets.
Characterization and biochemical activities of novel functional antimicrobial peptide (AMP) from Trichogramma chilonis
Authors: V. Sunil Shimoga , Santosh Kumar Hulikal S. , N. Pramod Siddanakoppalu , T. Prabhakar Betadthunga , B.N. Naika Mahanthesh , G. Thippeswamy Thippande , Niranjana Pathappa 
Published: November 2022

Introduction and Aim: The antimicrobial peptides (AMPs) are generally found in invertebrates, mammals, birds, plants and insects. AMPs produced by insect parasitoids contribute to innate immunity to resist infection due to lack of adaptive immunity. T. chilonis is one of the most effective endoparasitoid wasps for controlling lepidopterous insects. Several attempts have been made to isolate, characterize and develop a commercially viable product of AMPs from various insect sources. The present study aimed to characterize AMP from T. chilonis for potential antimicrobial and anti-cancer properties.

Methods: AMP was identified through T. chilonis transcriptome sequence and designed in silico and synthesized. Its purity was quantified using RP-HPLC, and the mass identified by mass spectrophotometry. LC/MS-MS was employed to predict the sequence and the BLAST program used to compare the sequence. AMP was tested for haemolytic activity and antimicrobial activity. Two pathogenic bacteria and fungal strains were used and IC50 values and MIC values were predicted against microbial strains.

Results: Synthetic peptide was found to be 95% homogenous with molecular weight of 3.48 kD. The peptide was identified to be a novel antimicrobial peptide consisting of 33 amino acid residues, and has a low computed instability index of -0.1.55 with high hydrophobic ratio of 27.27%. The antimicrobial activity revealed that T. chilonis antimicrobial peptide (TC-AMP) strongly inhibits the growth of selected human bacterial and fungal pathogens. While the haemolytic assay showed that the peptide did not obliterate human RBC in vitro. TC-AMP also showed an efficient inhibition of angiogenesis by in vivo model as evident by inhibition of vascularization.

Conclusions: AMP derived from the parasitoid has a potent antibiotic and anti-angiogenesis property. The peptide can be used as a potential antimicrobial and anticancer drug in near future with more detailed studies on its targeted applications.
A comparative evaluation of six sigma metrics and quality goal index ratio 3 months prior to first lockdown due to COVID-19 pandemic and 3 months during lockdown in a NABL accredited central laboratory
Authors: Sulthana P.K. Shirin , U. Raghavendra , Yassir Shaheena , Prasad V. Ganesh , Ansar Mohammed 
Published: November 2022

Introduction and Aim: Sigma represents Standard Deviation (SD) which indicates the degree of variation in a process, where the higher sigma value implies that less likely the laboratory reports false test results. Using a newer parameter called Quality Goal Index (QGI) we can find the reason behind the lower sigma value. Our study aimed to compare the six-sigma metric and QGI ratio 3 months prior to first lockdown due to COVID-19 pandemic and 3 months during the first lockdown.

Methodology: A retrospective study was used to compare the six-sigma metric and QGI ratio 3 months prior to first lockdown due to COVID-19 pandemic and 3 months during the first lockdown for the selected ten analytes from 1st of January 2020 to 30th of June 2020 from the clinical biochemistry section of Yenepoya Medical College Hospital, Deralakatte, Mangalore.

Results: The sigma metrics from January to March (level 1) indicated that urea, TSH, beta-HCG fell short of meeting Six Sigma quality performance and from April to June, glucose, creatinine, urea and ALT had metrics less than 3 at both the Internal Quality Control levels. QGI ratio indicated that from January to March, the problem was imprecision for urea, TSH and beta-HCG (QGI < 0.8). From April to June, urea and creatinine showed imprecision, glucose and ALT showed inaccuracy, urea and ALT showed both imprecision and inaccuracy.

Conclusion: This study highlights the necessity for stringent Internal Quality Control and External Quality Assurance monitoring even during the lockdown period of the pandemic. By implementing six sigma and finding QGI ratio, quality of laboratory services can be improved immensely.
Greimas‘s Three Aesthetics
Authors: Levina Jūratė 
Published: November 2022

The paper examines Algirdas Julien Greimas’s criticism on literature and arts and demonstrates that it is guided by three relatively independent theoretical perspectives. Greimas’s vision of the development of the Lithuanian novel implies a sociocultural literary theory, which expands on the premise that in its narrative forms, literature registers society’s sociocultural structure and simultaneously offers to its readers ways of self-perception. Hence the novel, according to Greimas, must capture the tensions of an individual’s self-positioning in his sociocultural milieu. The history of the plastic and fine arts inspired Greimas to look into the other dimension of art, namely the autonomy of artistic expression, defined as an internal cohesion of expressive forms that primarily communicate the manifestations of natural existence understandable across cultures. Yet it is poetry that Greimas considers the most affective art. He describes it as a discourse of individual self-experience and truth-telling in a singular language that supports the inner cohesion of the poet’s vision of the world and hence enables the constitution of sense in the act of reading. Greimas finds these effects realised most powerfully by three Lithuanian poets: Algimantas Mackus, Tomas Venclova, and Henrikas Radauskas.
Tatars by the Vokė River: Historical Memory and Personal Experiences
Authors: Leparskienė Lina 
Published: November 2022

In the historical narrative of Lithuania, the Vokė River is inseparable from the settling of Tatars in the territory of the Grand Duchy of Lithuania in the end of the 14th century, under the rule of Vytautas the Great. Until the present day, members of this Muslim ethnic community continue to live in villages and towns scattered along the banks of the river. According to their life stories, identity narratives and dreams analyzed in this article, the Tatars primarily perceive the landscape by the Vokė River through their community life, and in terms of their personal and family life evolving in this space. People reflecting on the historical narrative emphasize the importance of their voluntary decision to be there, contradicting popular historiographic theories of their ancestors having been moved there as prisoners of war or under the orders of the Lithuanian rulers. A string of villages situated along the Vokė River from its source to the mouth near the town of Grigiškės, have names that sound Turkic or Slavic; elderly local Tatars call them akolicas and point out to their peculiar layout, recognizing Tatar features even in the faces of the local inhabitants of other nationalities. The locals call their main settlement and the center of the Muslim community, the village of Keturiasdešimt Totorių (‘Forty Tatars’) in the Old Russian – Sorok Tatary. This place name was known as early as the 16th century, testifying to the deep entrenchment of the Tatar inhabitants in the culture of Lithuania, in which the Old Russian language was used for official writings and spoken by the nobility. From the 17th century, the Polish language took over, becoming both written and spoken language, adopted by the noble Tatars as well. Currently, local Tatars mostly use the local Belorussian dialect or Polish and Russian languages; this sets them apart from their fellow-countrymen living in the Kaunas Region who have started speaking Lithuanian during the interwar period. The author of the article regards Slavic languages as part of the cultural identity of the Vilnius Region and as an important mark of the ethnic Tatar culture related to their regional and noble identity, and to their attempts at fostering the Tatar families by means of frequently seeking spouses from the Tatar settlements in Belarus or Poland.
Precipitation biases and snow physics limitations drive the uncertainties in macroscale modeled snow water equivalent
Authors: Cho Eunsang , Vuyovich Carrie M. , Kumar Sujay V. , Wrzesien Melissa L. , Kim Rhae Sung , Jacobs Jennifer M. 
Published: November 2022

Abstract. Seasonal snow is an essential component of regional and global
water and energy cycles, particularly in snow-dominant regions that rely on
snowmelt for water resources. Land surface models (LSMs) are a common
approach for developing spatially and temporally complete estimates of snow
water equivalent (SWE) and hydrologic variables at a large scale. However,
the accuracy of the LSM-based SWE outputs is limited and unclear by mixed
factors such as uncertainties in the meteorological boundary conditions and
the model physics. In this study, we assess the SWE, snowfall,
precipitation, and air temperature products from a 12-member ensemble –
with four LSMs and three meteorological forcings – using automated SWE,
precipitation, and temperature observations from 809 Snowpack Telemetry
stations over the western US. Results show that the mean annual maximum LSM
SWE is underestimated by 268 mm. The timing of peak SWE from the LSMs is on average 36 d earlier than that of the observations. By the date of peak
SWE, winter accumulated precipitation is underestimated (forcings mean: 485
mm vs. stations: 690 mm). In addition, the precipitation partitioning
physics generates different snowfall estimates by an average of 113 mm with the same forcing data. Even though there are widespread cold biases (up to 3 ∘C) in the temperature forcings, larger ablations and lower ratios of SWE to total precipitation are found even in the accumulation period, indicating that melting physics in LSMs drives some SWE uncertainties. Based on the principal component analysis, we find that
precipitation bias and partitioning methods have a large contribution to the first principal component, which accounts for about half of the total
variance. The results provide insights into prioritizing strategies to
improve SWE estimates from LSMs for hydrologic applications.
APLIKASI PENDAFTARAN TES COVID BERBASIS WEB
Authors: Ningsih Rahayu , Prayoga Muhammad Yoviansyah 
Published: November 2022

Karena virus Covid-19 yang menyebar di negara kita, Pemerintah menghimbau bagi masyarakat untuk dapat segera memeriksa kondisi fisik di rumah sakit apakah di dalam tubuh kita terdeteksi adanya virus Covid-19, tetapi jika setiap orang datang ke rumah sakit dikhawatirkan akan timbul masalah antrian yang memperburuk penyebaran virus tersebut. Dalam hasil observasi yang dilakukan oleh peneliti di rumah sakit premier di temukan belum adanya sebuah aplikasi pendaftara untuk pasien yang ingin melakukan tes covid, sehingga untuk masyarakat yang ingin melakukan tes covid harus datang ke rumah sakit dan terjadi penumpukan pendaftar yang akhirnya tidak sesuai dengan anjuran pemerintah unuk menjaga jarak di tempat umum. Untuk itulah peneliti membuat sebuah aplikasi pendaftaran tes covid-19 secara online, yang bertujuan agar setiap orang dapat mendaftarkan dirinya tanpa perlu mengantri di loket rumah sakit. Penelitian ini menggunakan metode observasi, studi kepustakaan di dalam pengumpulan datanya, metode waterfall dipergunakan untuk pengembangan perangkat lunaknya. Aplikasi yang digunakan adalah PHPMyAdmin dan MySQL. Hasilnya adalah dengan adanya aplikasi ini pengunjung hanya datang ke rumah sakit ketika sudah melakukan pendaftaran dan pembayaran secara online, dan petugas cukup memvalidasi berkas yang dibawa oleh pasien, dan rumah sakit dapat melakukan penyimpanan proses pendaftaran menjadi lebih rapih dan baik.
Treatment of neuromuscular dysplasia of the vesicoureteral segment of the ureters in children
Authors: Ibodov H. , Mirakov Kh. M. , Rofiev R. , Davlatov A. , Ibodov N. S. 
Published: November 2022

Aim. To optimize conservative and surgical treatment of neuromuscular dysplasia of the vesicoureteral segment in children.Materials and methods. Study included 84 operated children with neuromuscular dysplasia of the vesicoureteral segment of the ureters. Megaureter antenatally diagnosed in 28 (25.4%) children: Ι degree - in 5, II degree - in 9, III degree - in 10, IV degree - in 4 children. The main criteria for diagnosing a megaureter in the perinatal period are an expansion of the anterior-posterior size of the pelvis, visualization of the dilated ureter, and in СFM - identification of weakening of the renal blood flow in the affected side.Results and discussion. As a result of the conservative and minimally invasive therapy – stenting of the ureters for up to 2 years, urodynamics were restored and the phenomena of ureterohydronephrosis were eliminated in 30 (27.2%) patients. In 32 (29%) patients, percutaneous puncture nephrostomy was performed, aimed at reducing the collecting system of the kidney, and ureter, as well as preparing for surgical treatment. The operated patients (84) were divided into 3 groups: Group I - operated according to the Politano-Ledbetter method (29); Group II - according to Cohen (20); Group III operated according to the method of extravesical reimplantation of the ureter with antireflux protection, developed in the clinic of pediatric surgery (35). Complications were noted in 8 (27.5%) patients after the Politano-Ledbetter operation; in 4 (20%) cases after the Cohen method operation; and in 5 (14.2%) cases after the extravesical reimplantation with antireflux protection.Conclusion. The method of ureteral reimplantation, developed and tested at the Clinic of Pediatric Surgery, is a fairly effective way to treat megareteral disease in children. This technique is highly effective in children older than 1-3 years, which makes 85.8%.
O Remédio e a bula: a memória involuntária e o olfato em Cloro, de Alexandre Vidal Porto
Authors: Tavares José Luiz Cordeiro Dias , Cardoso Elizabeth 
Published: November 2022

RESUMO Este artigo propõe analisar o romance Cloro de Alexandre Vidal Porto tendo, como referência, o conceito de memória involuntária de Walter Benjamin assim como as reflexões de Gagnebin sobre o tema e contando, ainda, com o auxílio de algumas noções freudianas sobre a memória. O romance nos apresenta Constantino, personagem principal cuja existência é marcada por conflitos relacionados à sua sexualidade em relatos nos quais sobressaem diversos odores que pontuam sua história de vida por meio de lembranças que ocupam o centro da narrativa.
PALAVRAS-CHAVE
Cloro; Memória; Walter Benjamin; Sigmund Freud; Alexandre Vidal Porto
Gozoso e doloroso: a estética do corpo no romance As pequenas mortes de Wesley Peres
Authors: Gonçalves Fábio Tibúrcio , Borges Luciana 
Published: November 2022

O presente artigo analisa o romance As pequenas mortes (2013), de Wesley Peres, ressaltando a representação estética do corpo na narrativa. A partir de considerações sobre a literatura brasileira contemporânea, a análise da representação do corpo físico do personagem Felipe Werle aborda a dicotomia existencial de um corpo que goza, mas que também sofre pelo mesmo motivo: é corpo. A sustentação teórica dos conceitos de gozo e dor, baseada nos estudos psicanalíticos empreendidos por pesquisadores, dedica-se a inventariar e explicitar as pulsões obsessivas do narrador em torno do sexo, da morte e do câncer, as quais fazem do corpo do protagonista objeto de análise e descrição de seus próprios excessos, culminando em uma estética cuja urdidura é tecida ao longo do discurso literário, altamente poético, filosófico e metaficcional.
Palavras–chave: Wesley Peres; Literatura contemporânea; Corpo; Gozo
Os espelhos na literatura: a (des)construção intertextual
Authors: Campigotto Aquino Ivânia , Azevedo Gilmar 
Published: November 2022

Este artigo reflete sobre a recriação textual como apropriação e/ou (re)construção de formas e temas de outras obras para a composição de outro texto na relação texto-base (primitivo) e texto parodiado ou parafraseado (derivados) e nisso a demarcação das fronteiras entre o imaginário e o simbólico. Segue-se a linha da literatura comparada onde o texto pode ser produzido a partir do diálogo, do hibridismo, de trocas e de retomadas em que a máscara investe na duplicidade no plano do conteúdo e na percepção e significação no plano da interlocução do discurso. Igualmente, serve-se da Semiótica no sentido de que no signo o antecedente-expressão mostra-se no corpo-objeto ou no corpo-sujeito no ato do destruir para (re)construir, de reler para reescrever ao usar o duplo na linguagem e no sentido nas teses da máscara em Josef; dos espelhos em Eco; do “empoderamento” em Foucault, da desconstrução em Culler, da carnavalização em Kristeva e da recriação intertextual em Sant´Anna, Dixon e Weschefelder. E isso aplicado nos contos de Ovídio (A beleza de Narciso) como texto primitivo para a paródia de Machado de Assis (O espelho) e este em diálogo parafrásico com O espelho, de Guimarães Rosa.
PALAVRAS-CHAVE: Recriação intertextual; Literatura comparada; Semiótica.
Novel Reading as Aesthetic: The Nesting of Aesthetic Experiences and Reproduction of Aesthetic Perception
Authors: Li Zhaoming 
Published: November 2022

Abstract
This article discusses the nesting of the individual aesthetic experience and the reproduction process of aesthetic perception when an individual reads a novel. The essence of the “boundary” of the novelistic space is discussed first. This aesthetic process examines the relationship with the boundary of novelistic space. Next, I discuss two cognitive and dynamic outcomes that arise from the stimulation of “intervention” during the nesting of aesthetic experiences inside and outside the boundary. Finally, I argue that the reproduction process of aesthetic perception usually comes in the form of the “co-construction of opposites” due to the nesting of aesthetic experiences. This structure will make each individual's aesthetic experience distinctive and unique. In this research, a new viewpoint for reference will also be provided to research the arts’ aesthetic process in other forms.
G. H. Mead: Socially Structured Aesthetic Experiences
Authors: Wertz S. K. 
Published: November 2022

Abstract
In speaking of his analyses, George Herbert Mead (1863–1931) announces: “It is behavioristic where the approach to experience is made through conduct.” He turns this approach to the practice of the arts and the aesthetic experience. His approach consists of an analysis of gestures and attitudes as the beginning of acts that we bring with us to the activities in which we are engaged. A gesture would be, for example, offering someone a chair who has entered a room. Usually gestures and their responses form a conversation, in this case, acceptance or rejection of the offer. The attitude behind the offer would be generosity and friendliness—a sign of welcome. Within music, “a temporal dimension as that of the melody, or recognition of the notes and their distance from each other in the scale, and our appreciation of these as actually affected by the beginning of our response to the later notes, as when we are expecting a certain sort of ending . . . . It is that attitude that gives the character of our appreciation of all extended musical compositions.” Instead of the part–whole understanding of the arts, he argues for a whole–part relationship within a social context of the actions that make up a performance or object. How far will this thesis take us? I explore answers to this question.
Pedagogy, Hyperreality, and Agency—To Sound Out Education Effects Ascribed to a Video Game
Authors: Kraus Anja 
Published: November 2022

Abstract
Whereas utopia is the vision of an ideal community, dystopias create the image of a cataclysmic decline of society and environment. This article deals with the construction of personal agency and the analysis of digital simulation that is reflected in an online commercial for a first-person survival horror video game. Agency is understood here as the capacity to act in the virtual environment that is ascribed to the actor by the marketing strategy. Applying approaches from phenomenology, simulation theory, and sound studies, the analysis proceeds in reference to a corresponding educational political agenda. The findings show a certain discrepancy between the more utopian education political rhetoric and the more dystopian construction of personal agency in the video game context, a discrepancy from which specific educational challenges emerge. Finally, even if a case study generally cannot be seen as representative, its results present a direction for the further investigation of virtual reality from the education perspective as suggested by international policies.