bluuebunny/crossref_metadata_2025_split huggingface dataset:
Iatrogenic hyperthyroidism in primary congenital hypothyroidism: prevalence and predictive factors
Authors: Chooprasertsuk Nuanpan , Dejkhamron Prapai , Unachak Kevalee , Wejaphikul Karn 
Published: September 2022

Abstract

Objectives
Primary congenital hypothyroidism (CH) is a preventable cause of mental retardation. Iatrogenic hyperthyroidism has occasionally been reported using the recommended LT4 dosage. Currently, information regarding iatrogenic hyperthyroidism and predictive factors for permanent hypothyroidism (P-CH) among Thai patients is lacking. The aim of this study is to determine the prevalence and factors for predicting iatrogenic hyperthyroidism at one month after LT4 initiation and for predicting P-CH in primary CH infants.

Methods
This retrospective cohort study involved 87 infants with primary CH. Patients were classified by thyroid status at one month after LT4 initiation. At 3 years, patients were reevaluated after LT4 cessation and assigned as P-CH or transient CH (T-CH). Differences between groups were analyzed.

Results
One month after LT4 initiation, 35.6% of patients were classified as having iatrogenic hyperthyroidism. An initial LT4 dose of 10.2 μg/kg/day (sensitivity 64.5%, specificity 71.4%) was a suitable cutoff value for predicting iatrogenic hyperthyroidism, wherein 55.6 and 21.6% of patients were treated with initial doses of ≥10.2 and <10.2 μg/kg/day, respectively (p=0.004). Initial LT4 dose was the only predictive factor for thyroid status after initial treatment. At reevaluation, 47.4% of patients were diagnosed with P-CH. LT4 dosage at 3 years of age was significantly higher in patients with P-CH (3.3 vs. 2.85 μg/kg/day, p=0.02) and the only relevant factor for predicting P-CH.

Conclusions
Iatrogenic hyperthyroidism is common among infants with primary CH when treated with the recommended LT4 dosage. LT4 dose was the only factor for predicting iatrogenic hyperthyroidism after LT4 initiation and the diagnosis of P-CH.
Study of the frequency and clinical features of maturity-onset diabetes in the young in the pediatric and adolescent diabetes population in Iran
Authors: Zamanfar Daniel , Ferdosipour Fatemeh , Ebrahimi Pirooz , Moghadam Mohamad , Amoli Mahsa M. , Asadi Mojgan , Monajati Mahila 
Published: September 2022

Abstract

Objectives
Maturity-onset diabetes of the young (MODY), an autosomal dominant disease, is frequently misdiagnosed as type 1 or 2 diabetes. Molecular diagnosis is essential to distinguish them. This study was done to investigate the prevalence of MODY subtypes and patients’ clinical characteristics.

Methods
A total of 43 out of 230 individuals with diabetes were selected based on the age of diagnosis >6 months, family history of diabetes, absence of marked obesity, and measurable C-peptide. Next-generation and direct SANGER sequencing was performed to screen MODY-related mutations. The variants were interpreted using the Genome Aggregation Database (genomAD), Clinical Variation (ClinVar), and pathogenicity prediction tools.

Results
There were 23 males (53.5%), and the mean age at diabetes diagnosis was 6.7 ± 3.6 years. Sixteen heterozygote single nucleotide variations (SNVs) from 14 patients (14/230, 6%) were detected, frequently GCK (37.5%) and BLK (18.7%). Two novel variants were identified in HNF4A and ABCC8. Half of the detected variants were categorized as likely pathogenic. Most prediction tools predicted Ser28Cys in HNF4A as benign and Tyr123Phe in ABCC8 as a pathogenic SNV. Six cases (42.8%) with positive MODY SNVs had islet autoantibodies. At diagnosis, age, HbA1c, and C-peptide level were similar between SNV-positive and negative patients.

Conclusions
This is the first study investigating 14 variants of MODY in Iran. The results recommend genetic screening for MODY in individuals with unusual type 1 or 2 diabetes even without family history. Treatment modifies depending on the type of patients’ MODY and is associated with the quality of life.
Characteristics and Impact of the rNST GABA Network on Neural and Behavioral Taste Responses
Authors: Travers Susan P. , Kalyanasundar B. , Breza Joseph , Houser Grace , Klimovich Charlotte , Travers Joseph 
Published: September 2022

AbstractThe rostral nucleus of the solitary tract (rNST), the initial CNS site for processing gustatory information, is comprised of two major cell types, glutamatergic excitatory and GABAergic inhibitory neurons. Although many investigators have described taste responses of rNST neurons, the phenotypes of these cells were unknown. To directly compare the response characteristics of both inhibitory and noninhibitory neurons, we recorded from mice expressing Channelrhodopsin-2 (ChR2) under the control of GAD65, a synthetic enzyme for GABA. We observed that chemosensitive profiles of GABAergic taste neurons (G+TASTE) were similar to non-GABA taste neurons (G-TASTE) but had much lower response rates. We further observed a novel subpopulation of GABA cells located more ventrally in the nucleus that were unresponsive to taste stimulation (G+UNR), suggesting pathways for inhibition initiated by centrifugal sources. This preparation also allowed us to determine how optogenetic activation of the rNST GABA network impacted the taste responses of G-TASTEneurons. Activating rNST inhibitory circuitry suppressed gustatory responses of G-TASTEneurons across all qualities and chemosensitive types of neurons. Although the tuning curves of identified G-TASTEwere modestly sharpened, the overall shape of response profiles and the ensemble pattern remained highly stable. These neurophysiological effects were consistent with the behavioral consequences of activating GAD65-expressing inhibitory neurons using DREADDs. In a brief-access licking task, concentration-response curves to both palatable (sucrose, maltrin) and unpalatable (quinine) stimuli were shifted to the right when GABA neurons were activated. Thus, the rNST GABAergic network is poised to modulate taste intensity across the qualitative and hedonic spectrum.
E2/E3‐independent ubiquitin‐like protein conjugation by Urm1 is directly coupled to cysteine persulfidation
Authors: Ravichandran Keerthiraju E , Kaduhr Lars , Skupien‐Rabian Bozena , Shvetsova Ekaterina , Sokołowski Mikołaj , Krutyhołowa Ros´cisław , Kwasna Dominika , Brachmann Cindy , Lin Sean , Guzman Perez Sebastian , Wilk Piotr , Kösters Manuel , Grudnik Przemysław , Jankowska Urszula , Leidel Sebastian A , Schaffrath Raffael , Glatt Sebastian 
Published: September 2022

AbstractPost‐translational modifications by ubiquitin‐like proteins (UBLs) are essential for nearly all cellular processes. Ubiquitin‐related modifier 1 (Urm1) is a unique UBL, which plays a key role in tRNA anticodon thiolation as a sulfur carrier protein (SCP) and is linked to the noncanonical E1 enzyme Uba4 (ubiquitin‐like protein activator 4). While Urm1 has also been observed to conjugate to target proteins like other UBLs, the molecular mechanism of its attachment remains unknown. Here, we reconstitute the covalent attachment of thiocarboxylated Urm1 to various cellular target proteins in vitro, revealing that, unlike other known UBLs, this process is E2/E3‐independent and requires oxidative stress. Furthermore, we present the crystal structures of the peroxiredoxin Ahp1 before and after the covalent attachment of Urm1. Surprisingly, we show that urmylation is accompanied by the transfer of sulfur to cysteine residues in the target proteins, also known as cysteine persulfidation. Our results illustrate the role of the Uba4‐Urm1 system as a key evolutionary link between prokaryotic SCPs and the UBL modifications observed in modern eukaryotes.
Does raising bank capital limit bank liquidity creation? Evidence from commercial banks in Vietnam
Authors: Thi Pham Xuan Thanh , Ho Tin Huu , Tran Nguyen Ha Thai , Ngo Thanh Phu 
Published: September 2022

Little is known about the trade-off mechanism underlying raising bank capital and enhancing bank liquidity creation, as empirical evidence is sparse. Pursuing Basel II target capital seems challenging and costly because it could generate unintended consequences, such as reducing liquidity creation. Thus, the aim of this study is to point out that the pursuit of raising capital to meet Basel II standards in recent years has limited the liquidity creation function of banks. This finding is reliable and consistent across different research methods, i.e. least absolute shrinkage and selection operator (LASSO regression) and the simultaneous equations model (SEM). We chose Vietnam's banking system for this study because applying Basel II in Vietnam has been topical in recent years and also more challenging than in the rest of the world. Our finding strengthens academically the financial fragility-crowding out hypothesis developed by Diamond & Rajan (2000).
PROSES PENGOLAHAN UDANG VANNAMEI (Litopenaeus vannamei) KUPAS MENTAH BEKU PD (PEELED DEVEINED) DI PT. INDOKOM SAMUDRA PERSADA – LAMPUNG SELATAN
Authors: Lestari Andini Wina , Handoko Yudi Prasetyo , Siregar Arpan Nasri 
Published: September 2022

Udang merupakan produk hasil perairan yang mudah rusak dan menjadi komoditas ekspor utama Indonesia, sehingga diperlukan pengawasan dan sistem pengendalian terhadap jaminan mutu dan kemanan pangan. Tujuan penelitian ini yaitu untuk mengetahui alur proses pengolahan udang vannamei kupas mentah beku, penerapan rantai dingin selama proses pengolahan, mutu bahan baku dan produk akhir, rendemen, produktivitas tenaga kerja, penerapan persyaratan kelayakan dasar dan penanganan limbah. Penelitian menggunakan metode observasi dan survei, dengan mengikuti secara langsung seluruh alur proses mulai dari penerimaan bahan baku hingga pemuatan. Analisa data dilakukan dengan deskriptif, komparatif dan kuantitatif. Hasil penelitian menunjukkan bahwa alur proses pengolahan udang vannamei kupas mentah beku di PT. Indokom Samudra Persada berbeda dengan alur proses pada SNI 3457:2014 dan rantai dingin telah diterapkan dengan baik sehingga suhu udang dan air < 5°C. Hasil pengujian mutu organoleptik dan sensori adalah 9, hasil pengujian mikrobiologi dan kimia sesuai dengan standar serta not detected untuk hasil pengujian antibiotik dan turunan nitrofuran. Hasil perhitungan rendemen pada setiap size telah sesuai dengan standar perusahaan yaitu tahap pemotongan kepala 67-68% dan rendemen pengupasan kulit 82-83%. Hasil perhitungan produktivitas pemotongan kepala, pengupasan kulit dan pencukitan usus telah memenuhi standar yang ditetapkan. PT. ISP telah menerapkan persyaratan kelayakan dasar dengan sangat baik (A) dan memiliki Instalasi Pengolahan Air Limbah (IPAL) yang baik.
KAJIAN MUTU IKAN PINDANG LEMURU (Sardinella lemuru) DALAM KEMASAN POLYPROPYLENE NON VAKUM SELAMA PENYIMPANAN SUHU RUANG DAN DINGIN
Authors: Permadi Aef , Afifah Rufnia Ayu , Herliza Nova , Asriani Asriani , Nurbani Siti Zachro 
Published: September 2022

Ikan pindang merupakan produk hasil perikanan yang mudah rusak, upaya untuk memperpanjang daya awet nya yaitu dengan pengemasan mengggunakan kemasan polypropylene selama penyimpanan pada suhu yang tepat (Wulandari dan Waluyo, 2013). Tujuan penelitian ini yaitu untuk mengetahui alur proses pengolahan ikan pindang dan mengetahui mutu ikan pindang dalam kemasan polypropylene non vakum selama penyimpanan suhu ruang dan suhu dingin. Metode pengambilan data dilakukan menggunakan dua metode yaitu primer dan sekunder dengan analisa data yang digunakan adalah metode statistik deskriptif. Penelitian menunjukkan bahwa alur proses pengolahan ikan pindang lemuru di UKM Poklahsar Maju Jaya belum sesuai standar SNI 2717:2017. Hasil uji mutu sensori ikan pindang memiliki nilai rata-rata yaitu 8 dan masih memenuhi standar SNI ikan pindang 2717:2017 yaitu maksimal 7. Hasil uji ALT ikan pindang memenuhi standar SNI ikan pindang 2707:2017 yaitu 1,0 × 10⁵ kol/gr. Pada pengujian ikan pindang selama penyimpanan suhu ruang dengan hasil uji ALT pada hari ke-1 ikan pindang sudah tidak memenuhi standar SNI yang telah ditentukan. Pada penyimpanan suhu dingin pada hari ke 12 ikan pindang sudah tidak memenuhi standar SNI 2707:2017. Uji sensori pada hari ke 1 ikan pindang sudah tidak disukai oleh panelis sedangkan pada suhu dingin hari ke 14 nilai ikan pindang sudah melewati batas maksimal. Pada uji kadar air tidak terjadi peningkatan kadar air secara signifikan dan dengan nilai rata-rata sudah diatas standar SNI 2717:2017 yaitu 60%. Berdasarkan hasil pengujian pada suhu ruang ikan pindang lebih cepat terjadinya pembusukan dibandingkan dengan suhu dingin..
Multimedia writing procedures for musical composition, seven case studies
Authors: Covarrubias Sabina 
Published: September 2022

The purpose of this article is to describe the multimedia writing (MW) procedures that have proven to be effective in resolving some of the difficulties faced by composers in: 1. notation of timbre, 2. notation of new performance modes, 3. notation of new vocal techniques, 4. notation of a tonal language in a score, 5. notation of the instructions for the use of the computer programs contained in the work, 6. synchronization of the oral tradition musicians with the audio recordings, and 7. time reduction during the learning of the work. To address these issues, we used MW in six "experiments" —composition projects designed to answer specific questions about notation. These experiments and other subsequent projects allowed us to confirm our findings. In our experiments, MW was a set of procedures that allowed information to be represented in different ways simultaneously. The information can be text, sound, still or moving images, among others. These procedures can be used to record a message with the aim of saving it and transferring it from the composer to the performer. The results obtained demonstrated the effectiveness of MW in overcoming the current limitations of the Western music writing system (WMWS).
Bipolar injury of the clavicle: A case report
Authors: Arcangelo Morizio , Andrea Leone , Claudio Maria Mori 
Published: September 2022

Introduction: Bipolar dislocation of the clavicle is an uncommon injury that is a simultaneous dislocation of the ipsilateral acromioclavicular joint and sternoclavicular joint. This injury is rare with fewer than fifty documented cases. Case report: We have reported the case of a forty-three-year-old bike trauma with posterior dislocation of the acromioclavicular joint and fracture of the medial part of the clavicle. Considering the young age of the patient and his requirement for high physical activity, we opted for the operative treatment. First, the patient was operated on with open reduction and stabilization of the acromioclavicular joint with 2 k. wires. So, thanks to conservative treatment at the medial fractures we had a good result. Conclusion: In light of current evidence, no important advice can be made about the treatment of bipolar clavicle fractures. We assume that the restoration of the anatomy of the acromioclavicular and sternoclavicular joints should be the aim of the treatment for this rare injury. Nevertheless, the treatment of a bipolar clavicle injury depends on different factors: injury pattern, age of the patient, daily activities, and comorbidity.
Salam As Banking Financing for Agriculture in Developing Countries: Lessons From Sudan
Authors: Mualley Salih Mustafa Ahmed , Moh'd Issa Salim 
Published: September 2022

The objective of this study is to measure the impact of commercial bank financing via Salam mode of finance on the Sudanese agricultural production and determine whether the Salam mode is suitable for financing agriculture or not. For the purpose of the analysis, the ordinary least squares method (OLS) was applied to a log - linear form of a simple regression model with a time series data on Sudan’s total annual agricultural production as a dependent variable and the commercial banks total annual financing via Salam for explanatory variable. The empirical results indicated that Salam mode of finance is appropriate for financing agriculture in Sudan due to its significant effects on agricultural production with a significant and positive relationship. In addition, agricultural sector highly contributed to the country economy during the study period and highly positively elastic to bank financing. However, it is hindered by heavy direct and indirect taxes, high marketing cost, long distance with poor rural infrastructure and weak agricultural returns. Therefore, relevant policy implications for both agriculture and bank financing are required. Hence, results of study suggest that banks should increase the provision for Salam mode for high agricultural production, reduce tax burdens, renovate the infrastructure, and facilitate financing procedures to agricultural sector.
Ekumenizm radykalny: Papież Jan Paweł II i Włodzimierz Sołowjow
Authors: Rojek Paweł 
Published: September 2022

Istnieje wiele świadectw, że Jan Paweł II wysoko cenił myśl Włodzimierza Sołowjowa. W 2000 r. papież wspominał o nim jako o „świadku wiary” , „wybitnym chrześcijańskim myślicielu” i „człowieku niezwykłej głębi”. W tym artykule próbuję przedstawić analizę niektórych podobieństw między tymi dwoma myślicielami. Po pierwsze, jak dostrzegało to wielu komentatorów, podzielali oni wspólną wizję zjednoczenie Kościołów katolickiego i prawosławnego. Po drugie, co wydaje mi się ważniejsze, mieli takie samo teologiczne rozumienie człowieka, świata i historii. Sądzę, że ta wspólna chrystocentryczna wizja jest nie tylko ostateczną podstawą wysiłków ekumenicznych, lecz także gruntem dla sformułowania prawdziwie chrześcijańskiej alternatywy dla świeckiej nowoczesności.
Zmysł dotyku w literackich reprezentacjach Nikołaja Leskowa
Authors: Trojanowska Beata 
Published: September 2022

Celem artykułu jest zaprezentowanie zmysłu dotyku w świecie przedstawionym wybranych tekstów prozatorskich rosyjskiego pisarza doby realizmu – Mikołaja Leskowa, jak również określenie reprezentatywnej dla ich haptyczności poetyki. W artykule zostały opisane wrażenia dotykowe, zarówno aktywne – gdy to Leskowowscy bohaterowie stają inicjatorami zwrotu haptycznego, jak i bierne – gdy to postaci są dotykane. Analiza wybranych tekstów pozwala na sformułowanie wniosku, iż poznanie haptyczne w przypadku analizowanych tekstów Leskowa jest głęboko osadzone w poetyce realizmu. Uwzględnienie jednak kontekstów kulturowych, zarówno ludowo-mitologicznych, jak i religijnych ujawnia ich ścisłe powiązanie z poetyką romantyczną. Pisarz w opisie sfery tykalnej swych bohaterów w sposób płynny przechodzi od materii do duchowości, magii, mistyki, łączy elementy gatunków ludowych z literaturą hagiograficzną. Leskowowska prezentacja zmysłu dotyku pokazuje potrzebę współistnienia i równowagi w człowieku zarówno poznania haptycznego materialnego, jak i poznania haptycznego „duchowego”. Nie bez znaczenia pozostaje także interpretacja haptyczności głównych bohaterów przez otoczenie, która ujawnia różnorodną optykę rosyjskiego społeczeństwa i staje się dodatkowym elementem jego charakterystyki.
Artificial Intelligence Techniques for the Prediction of Body Weights in Sheep
Authors: Hamadani Ambreen , Ganai Nazir Ahmad , Alam Safeer , Mudasir Syed , Raja Tariq A. , Hussain Ishraq , Ahmad Haider Ali 
Published: September 2022

Background: Artificial intelligence (AI) is transforming all spheres of life and it has the potential to revolutionize animal husbandry as well. In this regard, an attempt was made to compare two AI techniques for predicting 12-month body weights of animals; viz. Principal Component regression (PCR) and Ordinary Least Squares (OLS) for datasets of Corriedale sheep spanning 11 years. Methods: PCR models were trained by varying proportions of training and testing datasets. The dataset was subject to PCR before analysis and tested (PCA dataset). A separate dataset was also created by feature selection of the PCA (PCA+FS dataset) variables. Result: The highest correlation coefficients between test and predicted variables for two datasets (PCA dataset and PCA+FS dataset) created among the multiple models trained using PCR were 0.982 and 0.9741. In terms of error, R2 or correlation coefficient, the PCA dataset performed better than the PCA+FS dataset. The second principal component had the highest explained variance in OLS (86.16%) and the highest coefficient of determination (R2) using OLS was obtained for the PCA dataset viz. 0.980. It is concluded that both the algorithms tested in this study were satisfactorily trained in their prediction of the body weights with OLS performing better than PCA in terms of R2 value.
Adult Day Services, Health Equity for Older Adults With Complex Needs, and the COVID-19 Pandemic
Authors: Sadarangani Tina R. , Gaugler Joseph E. , Dabelko-Schoeny Holly , Marx Katherine A. 
Published: September 2022

Morbidity and mortality from COVID-19 have unduly affected older adults from racial and ethnic minority groups. In this article, we highlight the experiences and vulnerabilities of diverse older adults with complex health and social needs when their access to vital, but overlooked, community-based adult day service centers (ADSCs) was abruptly cut off during a pandemic. Pandemic-related ADSC closures left vulnerable older adults and their care partners without essential daily support and services, such as health monitoring and socialization. However, the magnitude of the impact of ADSC closures on well-being, particularly among members of racial/ethnic minority groups, has yet to be measured with any form of “big data” because large-scale, nationally representative data sets consisting of participant-level information and outcomes associated with ADSC participation do not yet exist. Unmet needs of older adults resulting from pandemic-related ADSC closures are underrecognized because of a lack of systematic data collection, undermining efforts to achieve health equity. We call on ADSCs to link rigorous collection of racial and ethnic data to quality measures of access to equitable “age-friendly” care as a means of better supporting diverse community-dwelling older adults beyond the COVID-19 pandemic. (Am J Public Health. 2022;112(10):1421–1428. https://doi.org/10.2105/AJPH.2022.306968 )
Racial and Socioeconomic Disparities in the Utilization of TKA Among Patients with Posttraumatic Knee Osteoarthritis
Authors: Atarere Joseph , Agudile Emeka , Orhurhu Vwaire , Agudile Ukamaka M. , Sorescu George , Suleiman Zakari Aliyu , Weaver Michael J. , Von Keudell Arvind 
Published: September 2022

Background:
Advanced posttraumatic osteoarthritis (PTOA) of the knee is a cause of substantial disability, particularly in younger individuals, and the treatment of choice is total knee arthroplasty (TKA). Racial and socioeconomic disparities exist in the use of TKA, but, to our knowledge, there have been no studies examining these disparities among patients with PTOA.

Methods:
We performed chi-square and logistic regression analyses on data from the Nationwide Inpatient Sample (NIS). The outcome of interest was the rate of TKA utilization, and the primary predictors were racial/ethnic group and insurance status. The regression models were adjusted for age, sex, household income, and Charlson Comorbidity Index (CCI).

Results:
The odds of receiving TKA for Black patients (odds ratio [OR] = 0.55; 95% confidence interval [CI], 0.48 to 0.62) and Hispanic patients (OR = 0.53; 95% CI, 0.46 to 0.62) were lower compared with White patients. Patients with Medicare (OR = 0.51; 95% CI, 0.46 to 0.57), those with Medicaid (OR = 0.48; 95% CI, 0.42 to 0.55), and those who self-paid (OR = 0.91, 95% CI: 0.14 to 0.25) had significantly lower odds of TKA compared with those with private insurance.

Conclusions:
Black and Hispanic patients are less likely than White patients to utilize TKA, and patients with private insurance are more likely to utilize TKA.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.