bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction Medical Vaste Utilizing Ensemble Machine Learning Algorithms: A Case from Turkey
Authors: Devrim-İçtenbaş Burcu , rouyendegh babak daneshvar 
Published: January 2022

Abstract
It is an important task to predict medical waste (MW) estimation accurately for effective Waste Management System (VMS). The main aim of this study was to compare three ensemble machine learning algorithms to predict medical waste for İstanbul which is the biggest city in Turkey. There exists new machine learning (ML) algorithms called Ensemble Machine Learning Algorithms that have shown significant success in other disciplines yet have not been examined for MW. To bridge the literature gap, in this study, for the first time, a total of three ensemble machine learning algorithms: Random Forests (RF), Gradient Boosting Machine (GBM) and AdaBoost are developed to predict MW generation. To employ this study. 17-years real data were obtained from İstanbul Metropolitan Municipality Department Open Data Portal with the input variables namely number of hospitals, number of bed available at the hospital, crude birth rate and Gross Domestic Product (GDP). 80% of the total database being used for developing the models, whereas the rest 20%  were used to validate the models In order to compare their performances, 5-fold cross-validation was applied and performance measures (MAE,RMSE and R-squared) were calculated in this study .Of the ensemble models, the RF model provided better performance than those of other models with RMSE, MAE, and R 2 of 1194.2, 898.12, 0.95, respectively, whereas the second best GBM accuracy with RMSE, MAE, and R 2 1290.76, 1160.43, 0.94, respectively. Although, CatBoost was interpreted as the efficient model for small datasets among the Machine Learning algorithms, was poorest accuracy with RMSE, MAE, and R 2 of 3349.57,2698.4,0.61. In addition, the findings revealed that GDP and number of hospitals were the most important inputs for the predicting MW generation using ensemble machine learning algorithms. These results will helpful for decision makers regarding both planning and designing medical waste management systems in the future facilities in the sense of sustainable management.
PENGARUH MEDIA SOSIAL, BRAND INFUENCER DAN KESADARAN MEREK TERHADAP MINAT BELI DI MARKETPLACE SHOPEE PADA SAAT PANDEMI COVID-19
Authors: Herdioko Jonathan , Karisma Carmel Verona 
Published: January 2022

ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh sosial media, brand influencer, dan kesadaran merek terhadap minat beli di Marketplace Shopee pada saat pandemi Covid-19. Penelitian ini menggunakan pendekatan kuantitatif dengan metode survey. Jumlah sampel pada penelitian ini sebanyak 157 responden yang tersebar di tiga wilayah antara lain Indonesia Bagian Barat, Indonesia Bagian Tengah, dan Indonesia Bagian Timur, pengambilan sampel menggunakan teknik purposive sampling. Hasil dari penelitian ini menunjukkan bahwa secara parsial variabel media sosial tidak berpengaruh signifikan terhadap minat beli, variabel brand influencer berpengaruh signifikan terhadap minat beli, variabel kesadaran merek berpengaruh terhadap minat beli. Asal daerah sebagai pemoderasi variabel brand influencer dan kesadaran merek tidak berpengaruh signifikan terhadap minat beli. Pendapatan sebagai pemoderasi variabel brand influencer dan kesadaran merek tidak berpengaruh signifikan terhadap minat beli. Kata Kunci: Media Sosial, Brand Influencer, Kesadaran Merek, Minat Beli ABSTRACT This research is aimed to acknowledge the effects of social media, brand influencer, and brand awareness towards Shopee Marketplace buying intention during the Covid-19 pandemic. This research uses the quantitative approach by survey. There were 157 samples used and they came from the three regions of Indonesia. The purposive sampling method was used in this research. The results of this study indicate that partially, the social media variable has no significant effect on buying interest, the brand influencer variable has a significant effect on buying interest, the brand awareness variable has an effect on buying interest. Regional origin as a moderating variable for social media and brand awareness has no significant effect on buying interest. Income as a moderating variable for brand influencers and brand awareness has no significant effect on buying interest. Keyword: Social Media, Brand Influencer, Brand Awareness, Buying Interes
Water quality analysis of old and new Phuleli Canal for irrigation purpose in the vicinity of Hyderabad, Pakistan
Authors: Panhwar Muhammad Yousif , Panhwar Sallahuddin , Keerio Hareef Ahmed , Khokhar Nadar Hussain , Shah Sabab Ali , Pathan Nasreen 
Published: January 2022

Abstract
Irrigation-water quality plays an important role in agriculture productivity. In this study, water quality of the old and new Phuleli canal located in Hyderabad, Pakistan, was characterized for irrigation purpose. Water samples were collected from four different locations of both the old and new Phuleli canal. Twelve different irrigation-water quality standards were assessed under the study: pH, Electricity Conductivity, Biochemical Oxygen Demand (BOD), Total Dissolved Solids, Chemical Oxygen Demand (COD), Dissolved Oxygen, Calcium, Magnesium, Sodium, Potassium, Sodium adsorption ratio, Fecal Coliforms. The results showed that the Electricity Conductivity ranges from 910–3,090 MS/cm, Potassium 13–112 mg/l, BOD 61–285 mg/l, COD 97–361 mg/l and Fecal Coliforms 400–2,350 MPN/100 ml concentrations in water of both canals were higher than the National Environmental Quality Standards permissible limits. It was found that the water quality parameters were higher than the permissible pollution level of canal water for the use of irrigation in agriculture.
Multifaceted Applications of Genetically Modified Micro-organisms: A Biotechnological
Revolution
Authors: Basarkar Vasavi , Govardhane Sharayu , Shende Pravin 
Published: January 2022

Background:
Genetically modified micro-organisms like bacteria, viruses, algae and fungi are novel
approaches used in the field of healthcare due to better efficacy and targeted delivery in comparison to conventional
approaches.

Objectives:
This review article focuses on the applications of genetically modified micro-organisms in the
treatment of cancer, obesity and HIV infection. The gut microbiome causes metabolic disorders, however, the
use of genetically modified bacteria alters the gut microbiota and delivers therapeutically effective drugs in the
treatment of obesity.

Methods:
Enhancement of the therapeutic activity of different micro-organisms is required for multiple treatments
in cancer, diabetes, etc., by incorporating their fragments into the microbial filaments with the help of
genetic modification approaches. Various methods like amelioration of NAPE synthesis, silica immobilization,
polyadenylation and electrochemical are used to integrate the strain into the bacteria and engineer a live virus
with a peptide.

Results:
The development of novel microbial strains using genetic modifications over core strains offers higher
precision, greater molecular multiplicity, better prevention from the degradation of microbes in atmospheric
temperature and significant reduction of side effects for therapeutic applications. Moreover, genetically modified
micro-organisms are used in multidisciplinary sectors like generation of electricity, purification of water,
bioremediation process, etc., indicating the versatility and scope of genetically engineered microbes.

Conclusion:
The bioengineered micro-organisms with genetic modifications proved to be advantageous in various
conditions like cancer, diabetes, malaria, organ regeneration, inflammatory bowel disease, etc. This article
provides insight into various applications of genetically modified microbes in different sectors with their implementation
for regulatory approval.
Fish Gelatin: Current Nutritional, Medicinal, Tissue Repair Applications, and as a
Carrier of Drug Delivery
Authors: Soliman Amro M. , Teoh Seong Lin , Das Srijit 
Published: January 2022

Abstract:
Gelatin is obtained via partial denaturation of collagen and is extensively used in various industries.
The majority of gelatin utilized globally is derived from a mammalian source. Several health and religious concerns
associated with porcine/bovine gelatin have been reported. Therefore, gelatin from a marine source is
widely being investigated for its efficiency and utilization in a variety of applications as a potential substitute
for porcine/bovine gelatin. Although fish gelatin is less durable and possesses lower melting and gelling temperatures
compared to mammal-derived gelatin, various modifications have been reported to promote its rheological
and functional properties to be efficiently employed. The present review describes in detail the current
innovative applications of fish gelatin involving the food industry, drug delivery, and possible therapeutic
applications. Gelatin bioactive molecules may be utilized as carriers for drug delivery. Due to its versatility,
gelatin can be used in different carrier systems, such as microparticles, nanoparticles, fibers, and hydrogels. The
present review also provides a perspective on the other potential pharmaceutical applications of fish gelatin,
such as tissue regeneration, antioxidant supplementation, and antihypertensive and anticancer treatments.
Short Amphiphiles or Micelle Peptides May Help to Fight Against
COVID-19
Authors: Manna Sounik , Chowdhury Trinath , M. Mandal Santi , Choudhury Sujata Maiti 
Published: January 2022

Background:
COVID-19 is a worldwide threat because of the incessant spread of SARS-CoV-2 which urges the development of suitable antiviral drug to secure our society. Already, a group of peptides have been recommended for SARS-CoV-2, but not yet established. SARS-CoV-2 is an enveloped virus with hydrophobic fusion protein and spike glycoproteins.

Methods:
Here, we have summarized several reported amphiphilic peptides and their in-silico docking analysis with spike glycoprotein of SARS-CoV-2.

Result:
The result revealed the complex formation of spike protein and amphiphilic peptides with higher binding affinity. It was also observed that PalL1 (ARLPRTMVHPKPAQP), 10AN1 (FWFTLIKTQAKQPARYRRFC), THETA defensin (RCICGRGICRLL) and mucroporin M1 (LFRLIKSLIKRLVSAFK) showed the binding free energy more than -1000 kcal/mol. Molecular pI and hydrophobicity are also important factors of peptides to enhance the binding affinity with spike protein of SARS-CoV-2

Conclusion:
In the light of these findings, it is necessary to check the real efficacy of amphiphilic peptides in-vitro to in-vivo experimental set up to develop an effective anti-SARS-CoV-2 peptide drug, which might help to control the current pandemic situation.
Microbial Synthesis of Gold Nanoparticles and their Application
Authors: Chowdhury Neehasri Kumar , Choudhury Reshma , Gogoi Bhoirob , Chang Chung-Ming , Pandey Ramendra Pati 
Published: January 2022

Background:
Nanoparticles play a very important role in our daily lives and have a wide range of applications in agriculture and biology, such as antioxidants and antimicrobial compounds. Among them are gold nanoparticles (AuNPs) that are highly complex and are widely used. In recent years gold nanoparticles have attracted much attention because of their optical properties, electron-ic, physicochemical, and surface Plasmon resonance (SPR). Gold plated nanoparticles, similar to metal nanoparticles, have many unusual chemical and physical properties due to the effects of their quantum size and location compared to other iron or metal atoms. Gold nanoparticles can be used in pharmaceutical products such as antimicrobial and anti-biofilm agents, targeted delivery of anti-cancer drugs, biosensors, biocatalysis, bioremediation modification of toxic chemicals exposing the soil and atmosphere, dye reduction, etc. Yet such methods are expensive and out of harmony with nature. In that account, the microbes-mediated synthesis of gold nanoparticles recently changed rap-idly when pure microbes becoming ac-friendly, non-toxic, and biocompatible as physiological and chemical methods. This document aims to review the progress made in recent years with the fusion of gold nanoparticles. The microbial source includes bacteria, algae fungi. These works motivate people how to apply and synthesize gold nanoparticles. This review also focuses on the process of classification of gold nanoparticles, structures, and their use in the development of various require-ments.

Objective:
The main goal is to study gold nanoparticles and their application in the future.

Methods:
We studied different research papers, reviewed papers from “Google Scholar”, “NCBI”, “PubMed”, “Science Direct” made.
Conclusion: Metal nanoparticles are

Conclusion:
Metal nanoparticles are suitable for many emerging technologies. Understanding the microorganisms found in nature because the fusion of gold nanoparticles is required.
Biodegradable Polymers and their Applications: A Review
Authors: Bhovi Venkatesh K. , Melinmath Sulochana P. , Gowda Ranjith 
Published: January 2022

Abstract:
Polymers have an endless scope due to their flexibility, amendment, and modification with the organic and inorganic compounds. There is an intense competition between natural and synthetic biodegradable polymers concerning biodegradability and compatibility with modern technology. Biodegradable polymers play a significant role in sustaining humanity on the earth due to nonenvironmental hazards. These polymers play a crucial role in biomedicine technology, such as tissue engineering, preparation of different scaffolds, drug delivery systems, industrial sector, agriculture, and food packaging. Here, we probed on various applications, challenges, and the limitations of biodegradable polymers in life.
Structure-Based Drug Design and Development of Novel Synthetic Compounds
with Anti-Viral Property against SARS-COV-2
Authors: Tendulkar Reshma , Chouhan Aasma , Gupta Avika , Chaudhary Aaliya , Dubey Chandani , Shukla Sushil 
Published: January 2022

Background:
Structure, drug design, drug development, flavonoids, SARS-CoV-2, antiviral.

Objective:
The antiviral activity of various compounds of the flavonoid class was checked against
SARS-COVID-19 using diverse tools and software.

Method:
From the flavonoid compound class, 100 synthetic compounds with potential antiviral activity
were selected and improved for screening and induced fit docking, which was reduced to 25 compounds
with good docking scores and docking energies. In addition to the apparent match of the molecule
with the shape of the binding pocket, a full analysis of the non-covalent interactions in the active
site was assessed.

Results:
Compounds nol26, fla37-fl40, an32, an39 showed a maximum docking score, which shows
essential interactions for a tight bond. Now, all compounds are synthetic with beneficial drug-like
properties.

Conclusion:
During the docking study, an increased lipophilic interaction of compounds due to the
presence of chlorine in nol26, fla37-fl40, an32, an39 was discovered. fla37-fla40 can be investigated
as lead molecules against SARS-COV-2 in futuristic drug development.
Chiral NADH Model: Design, Synthesis, Asymmetric Reduction Reaction,
and Fluorescence Characteristics
Authors: Bai Cui-Bing , Zhang Lei-Yang , Wang Nai-Xing , Yan Zhan , Wu Yue-Hua , Xu Bao-Cai , Liu Ning , Wang Bo-Zhou , Tomasic Vesna 
Published: January 2022

Abstract:
A new type of NADH model compound, which has six asymmetric carbon centers, has
been synthesized by an efficient and convenient method. We used NADH models combined with
enzymes in the asymmetric reduction. It was the first time that dehydrogenase combined with
NADH models instead of inorganic catalysts, such as MgCl2, was used in the asymmetric reduction.
Furthermore, the experimental results showed that the new NADH model has the strongest
fluorescence emission properties compared to previously reported models.
A Study on Synthesis of Chalcone Derived -5- Membered Isoxazoline and
Isoxazole Scaffolds
Authors: Bendi Anjaneyulu , Singh Lakhwinder , Bhardwaj Sakshi 
Published: January 2022

Abstract:
Chalcone-derived isoxazole scaffolds remain the central focus due to their greater
biological, clinical, and pharmacological properties. The present study reviews the synthesis
of various chalcone derived - 5- membered isoxazoline and isoxazole scaffolds with the
available literature until 2021.
Adenosine Blood Level: A Biomarker of White Matter Damage in Very
Low Birth Weight Infants
Authors: Colella Marina , Panfoli Isabella , Doglio Matteo , Cassanello Michela , Bruschi Maurizio , Angelis Laura C. De , Candiano Giovanni , Parodi Alessandro , Malova Mariya , Petretto Andrea , Morana Giovanni , Tortora Domenico , Severino Mariasavina , Maghnie Mohamad , Buonocore Giuseppe , Rossi Andrea , Baud Oliver , Ramenghi Luca A. 
Published: January 2022

Background:
Very low birth weight infants are at risk of developing periventricular white matter lesions. We previously reported high blood adenosine levels in premature infants and infants with low birth weight. We asked whether blood adenosine levels could be related to the vul-nerability of the maturing white matter to develop lesions. The present study aims at finding a bi-omarker for the early detection of brain white matter lesions that can profoundly influence the neu-rodevelopmental outcome, whose pathophysiology is still unclear.

Methods:
Dried blood spots were prospectively collected for the newborn screening program and adenosine concentration measurements. Fifty-six newborns who tested four times for blood adeno-sine concentration (at days 3, 15, 30, and 40 post-birth) were included in the program. All infants underwent brain MRI at term equivalent age. Neurodevelopmental outcomes were studied with Griffiths Mental Development Scales (GMDS) at 12±2 months corrected age.

Results:
Blood adenosine concentration increased over time from a median of 0.75 μM at Day 3 to 1.46 μM at Day 40. Adenosine blood concentration >1.58 μM at Day 15 was significantly associat-ed with brain white matter lesions at MRI (OR (95 % CI) of 50.0 (3.6-688.3), p-value < 0.001). A moderate negative correlation between adenosine at 15 days of life and GMDS at 12 ± 2 months corrected age was found.

Conclusion:
These findings suggest a potential role for blood adenosine concentration as a bi-omarker of creberal white matter lesions in very low birth weight infants.
Clinical Evaluation of Exertional Dyspnea in Adult Pectus Excavatum Patients
Authors: Houle Mateo C. , Sjulin Tyson J. , McInnis Ian C. , Walter Robert J. , Morris Michael J. 
Published: January 2022

Abstract:
Evaluation of patients with pectus excavatum has primarily been focused and, especially
the pediatric population who undergoes surgical correction of sternal defects mainly for cosmetic
reasons combined with exercise-limiting symptoms. The extent of cardiopulmonary improvement
in this population based on cardiac imaging, pulmonary function testing, and cardiopulmonary exercise
testing may be highly variable. There is no current consensus on the limitations of cardiopulmonary
impairment or potential improvement from surgical repair in pediatric patients. Limited data
have been published in the medical literature on the evaluation of adults with pectus excavatum
who may also present with a variety of clinical symptoms. Adult patients with exercise limitation
and pectus excavatum may present with exertional dyspnea, chest discomfort, palpitations/tachycardia,
exercise-induced wheezing, and use of bronchodilators for asthma-like symptoms. While numerous
published review articles outline clinical evaluation and surgical treatment for younger patients,
comprehensive evaluation for these adult patients has not been fully elucidated. There is no
current consensus on the underlying cause of cardiopulmonary impairment in adult patients or their
potential improvement from surgical repair. This review focuses on the recommended evaluation
of adult patients to discern the potential cardiopulmonary limitations to exercise due to pectus excavatum,
especially in physically fit adults, such as active-duty military personnel. Two illustrative
cases are presented to describe the complexity of the evaluation for adult patients and the potential
need for surgical correction.
Maturity-onset Diabetes of the Young (MODY) in Pregnancy: A Review
Authors: Majewska Agata , Stanirowski Paweł , Wielgoś Mirosław , Bomba-Opoń Dorota 
Published: January 2022

Abstract:
Hyperglycaemia in pregnancy is one of the most common complications of pregnancy
and is generally diagnosed as gestational diabetes mellitus (GDM). Nevertheless, clinical symptoms
of hyperglycaemia in pregnancy in some cases do not match the clinical manifestations of
GDM. It is suspected that 1-2 % of women diagnosed with GDM are misdiagnosed maturity-onset
diabetes of the young (MODY). MODY often has a subclinical course; thus, it is challenging for
clinicians to aptly diagnose monogenic diabetes in pregnancy. Proper diagnosis is crucial for the
effective treatment of hyperglycaemia in pregnancy. Many studies revealed that misdiagnosis of
MODY increases the rate of complications for both mother and fetus. This literature review reports
the current knowledge regarding diagnosis, treatment, and complications of the most common
types of MODY in pregnancy.
Predictive Biochemical Factors for Pre-eclampsia in Early Pregnancy
Authors: Baron Lorna Muscat , Baron Byron 
Published: January 2022

Abstract:Pre-eclampsia (PE) is one of the major pregnancy complications, affecting up to 10 % of all pregnancies in some regions of the world. The clinical diagnosis, characterised by hypertension and proteinuria often late during pregnancy, with the added inability to treat (other than delivery), can lead to significant morbidity and mortality in both mother and unborn foetus. Moreover, as yet, only low dose aspirin administration is accepted as a preventive measure for PE. This puts more pressure to identify diagnostic and prognostic biomarkers of PE from blood or urine for the non-invasive screening of pregnant women before pregnancy becomes complicated. Over the years, a number of DNA and protein molecules, such as cell-free DNA, VEGF, sFLT1, PlGF, PP-13, ADMA, and several other biomarkers, have been linked to specific pathophysiological observations and proposed as predictive markers for PE. However, their reliability and reproducibility have been put to the test by numerous studies. The aim of this review is to cover the key clinical and biochemical features of pregnancies complicated by PE and evaluate the robustness of data gathered from various studies in order to better understand the link between the proposed biomarkers and the development of PE so as to better quantify their relevance in diagnostic or prognostic applications. The overall goal is to use such biomarkers for earlier detection, better molecular monitoring, and, where possible, lessening of symptoms, hopefully leading to a reduction in the yearly PE-related deaths worldwide.