bluuebunny/crossref_metadata_2025_split huggingface dataset:
A-157 G Syndrome in Adulthood: A Case Report
Authors: Scull Sara , Marschall Kelsea P , Plotnik Lisa , Stark Aleksandra , Thorp Karen , McLaren Jennifer , Lichtenstein Jonathan D 
Published: August 2022

Abstract
Objective: FG syndrome is an X-linked recessive disorder (p.R961W MED12 mutation) affecting phenotypic males and is characterized by intellectual disability, multiple congenital anomalies, hypotonia, constipation, and hyperactivity. Existing literature about syndromic presentations in adulthood is limited. This case study presents an adult with FG syndrome.
Method: Patient is a 39-year-old White cisgender male with FG syndrome and confirmed p.R961W mutation. Pertinent history includes agenesis of corpus callosum, moderate intellectual disability, communication disorder, Tourette’s syndrome, attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, bipolar disorder not otherwise specified, and posttraumatic stress disorder. Previous neuropsychological assessments found a generalized pattern of impairment. In early adulthood, the patient’s motor skills deteriorated, and he was hospitalized for aggression. At age 37, the patient was “declining” despite a normal CT scan (except for agenesis of corpus callosum) and development of intermittent paranoia and auditory and visual hallucinations.
Results: An interdisciplinary evaluation, performed via telehealth, was completed at an academic medical center. Cognitive changes were denied. Hyperactivity, angry outbursts, affability, and talkativeness were reported. Behavioral and psychiatric symptoms decreased since a change in residence and homecare providers.
Conclusions: Little is known about adults with FG syndrome. This case suggests that the behavioral phenotype of FG syndrome remains consistent into adulthood. While cognitive changes were not evident, a decline in motor function and the development of psychotic symptoms did occur. This case increases awareness about FG syndrome in adulthood and can inform clinical practice. Adults with FG syndrome can achieve meaningful goals with proper support from community services, supervised living, and therapeutic interventions.
A-158 Levels of Systemic Inflammation is Associated with Cognitive Function in People with Multiple Sclerosis
Authors: Collette Christopher W , Norling Amani M , Ward Katherine , Freeman Hyun , Myers Terina , Bashir Khurram , Lazar Ronald M , Gerstenecker Adam 
Published: August 2022

Abstract
Objective: To investigate the relationship between systematic inflammatory biomarkers and cognition in patients with Multiple Sclerosis (MS).
Method: We recruited 36 patients diagnosed with MS (31 with relapsing-remitting and 5 with progressive) who presented for treatment at the University of Alabama at Birmingham (UAB). Patients underwent a comprehensive neuropsychological battery, and serum blood samples were collected. Cognitive data was divided into an overall Cognitive Composite score and seven cognitive domains (i.e., Attention, Verbal Memory, Visual Memory, Visuospatial Ability, Language, Processing Speed, and Executive Function) using z-score averages. Pearson's product-moment correlations were conducted to determine the relationship between cognitive performance and 14 inflammatory biomarkers specifically chosen for their potential role in MS.
Results: Matrix Metalloproteinase-9 (MMP-9) was significantly correlated with Visual Memory (r= -.424; p=.01), Language (r= -.425; p= .01), and Cognitive Composite (r= -.380; p= .022) scores. Additionally, Insulin-like Growth Factor-1 (IGF-1) was significantly correlated with the overall Cognitive Composite (r= -.346; p= .039) score.
Conclusions: Studies investigating associations between inflammation and cognition in MS are lacking. In our sample of persons with Multiple Sclerosis, serum IGF-1 and MMP-9 biomarkers were moderately negatively correlated with the overall Cognitive Composite scores. MMP-9 was negatively correlated with Visual Memory and Language cognitive domain scores. These findings in a representative sample of patients with MS highlight the need for further research exploring the relationship between systematic inflammatory biomarkers and cognition in MS.
A-163 Neuropsychological Profile of Early Onset ADEM and AMSAN
Authors: Palmeri Maria J , Bronshteyn Diana , Facchini Ronda , Masur David , McGinley John , Weiss Erica 
Published: August 2022

Abstract
Objective: We present the neuropsychological profile of a 9-year-old girl with a history of waxing and waning ataxia, initially diagnosed at 18 months of age, with Acute Disseminated Encephalomyelitis (ADEM), later thought to be axonal motor sensory neuropathy (AMSAN). ADEM is a rapid onset neuroinflammatory disease typically seen in children ages 3-10 following infection, which results in demyelinating lesions. AMSAN is a rare variant of Guillain-Barre´ syndrome causing muscle/sensation difficulty. Common long-term cognitive correlates of ADEM include attention, processing speed and internalizing problems in the context of average overall cognition.
Method: Comprehensive neuropsychological evaluation referral by neurology to assist with continued workup given atypical history and unclear academic difficulties. Initial symptom workup revealed signal changes in spinal cord and demyelinating lesions in the left frontal lobe and upper cervical spine. She was treated with intravenous immunoglobulins (IVIG), but symptoms returned several months later and then again. Subsequent improvements with therapy for ataxia, speech and feeding difficulties.
Results: Overall cognitive functioning in the low average range with notable and extensive attentional limitations requiring continual prompting. Evaluation also revealed below grade and age level performance in all academic areas, significant oromotor and gross motor coordination difficulties, and mild self-esteem issues in this child who presented much younger than her chronological age.
Conclusions: This case demonstrates the importance of neuropsychological evaluation in pediatric paraneoplastic motor/sensory motor syndromes. While underlying cause of demyelination and ataxia in this case remains unclear, cognitive findings revealed significant areas that require intervention which could have been identified and supported earlier in her development.
A-170 Cognitive Functioning and Default Mode Network as Predictors of Smoking Severity in Adults
Authors: Fleischmann Holly , Hogan Kassidy S , Hargraves Tegan , Sarles-Whittlesey Heidi L , McIntyre-Wood Carly , Amlung Michael T , MacKillop James , Sweet Lawrence H 
Published: August 2022

Abstract
Objective: Smoking is a leading cause of avoidable death, with the best cessation treatments yielding only 10-30% abstinence. Limited neurocognitive research is available on the best predictor of cessation: addiction severity. We investigated whether smoking severity is associated with stronger resting functional connectivity and cognitive functioning.
Method: A community sample of 33 adult smokers (mean age=40.77, 72.73% female, 27.27% Black, &gt;10 cigarettes per day [CPD]) completed 8-minutes of resting state functional MRI and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Default network (DN) functional connectivity was conducted using four seed/target regions. RBANS total score was operationalized as overall cognitive function. Smoking severity was operationalized as CPD.
Results: Mean RBANS scores were in the average range (mean=89.76, SD=11.68) and predicted CPD (mean=20.14, SD=9.33), accounting for 20.30% of the variance (see Table). Associations between RBANS and CPD were significantly moderated by mean target region synchrony with three of four seed regions: posterior cingulate cortex (PCC), left posterior precuneus (LPP), and right posterior precuneus (RPP). Medial prefrontal cortex (MPFC) synchrony did not add to the prediction. Repeating these regressions, controlling for age, yielded the same pattern. The three DN seeds continued to yield mean target region effects that exhibited strong interactions with the RBANS to predict severity (see Table).
Conclusions: DN synchrony moderates the association between cognitive function and smoking severity, such that the negative relationship between overall cognitive functioning and smoking severity is only present for those with lower levels of DN synchrony. These markers may improve understanding of neurocognitive mechanisms of smoking severity.
A-172 Evaluating Associations Between the Five Negative Symptom Domains and Cognition in Schizophrenia
Authors: Woodyatt Jessica J , Allen Daniel N , Goodwin Grace , Paul Nina , Salva Christine , Strauss Gregory 
Published: August 2022

Abstract
Objective: Recently, factor analysis has supported a five-factor model of negative symptoms in schizophrenia (anhedonia, avolition, alogia, asociality, and blunted affect). Associations between these unique negative symptom domains and neurocognition are yet to be examined. The following study investigates relationships between the five distinct negative symptoms and cognitive functioning.
Methods: Outpatients diagnosed with schizophrenia (n=245) were assessed during periods of clinical stability for negative symptom severity using the Brief Negative Symptom Scale (BNSS). The MATRICS Consensus Cognitive Battery (MCCB) was used to assess seven domains of neurocognition, including processing speed, working memory, verbal learning, visual learning, reasoning, problem solving, and social cognition. To evaluate external correlates, the five-domain negative symptoms were correlated with measures of neurocognition.
Results: Greater negative associations were found between the five negative symptom domains with processing speed, attention, working memory, social cognition, and overall MCCB scores. Correlational analyses demonstrated the strongest negative relationships between the domain of attention with alogia and blunted affect.
Conclusions: The present study examined unique associations between cognitive abilities and the five negative symptom domains. Strong negative associations were found between negative symptoms and distinct measures of neurocognition, indicating a unique variance in cognitive performance correlates with severity of negative symptoms. Results suggest greater severity of negative symptoms is associated with greater impairments in select neurocognitive domains. Further research using analytic approaches would offer additional support for this hypothesis. Findings have implications for developing differential treatments targeting the five negative symptom domains separately, as they may have distinct underlying pathophysiological and neurocognitive mechanisms.
A-175 Regional Cerebral Blood Flow in Self-Reported Anxiety in Adults versus Children
Authors: Geller Rachel T , Golden Charles , Nunez Christina , Stafford Claire , Jaramillo Cristina , Amen Daniel , Willeumier Kristen 
Published: August 2022

Abstract
Objective: The aim of this study is to identify regional cerebral blood flow (rCBF) differences between children and adults with high levels of self-reported anxiety.
Method: Subjects were selected from two independent clinical outpatient databases for child and adult SPECT scans. Scores were standardized to T scores for each database. The highest 20% of self-reported anxiety was selected from each database. The final sample consisted of 3226 Adults [Mage=37.78, majority-white (68.7%) and male (54.7%)] and 545 children [Mage=13.58, majority-white (48.6%) and male (59.3%)] Significant differences existed between groups for gender and race. An ANCOVA was utilized to test the difference in concentration rCBF between adults and children controlling for these t covariates.
Results: Groups were compared across 17 variables representing different areas of the brain (p&lt;.05). Children had significantly higher rCBF than adults in the limbic [left: F(1,3767)=15.893, p&lt;.001 and right: F(1,3767)=48.699, p&lt;.001], basal ganglia [left: F(1,3767)=30.138, p&lt;.001 and right: F(1,3767)=61.191, p&lt;.001], frontal [left: F(1,3767)=142.244, p&lt;.001 and right: F(1,3767)=112.273, p&lt;.001], motor sensory right F(1,3767)=679.063, p=.008, and vermis F(1,3767)=50.025, p&lt;.001 regions. Adults had significantly higher rCBF than children in the parietal regions [left: F(1,3767)=42.235, p&lt;.001 and right: F(1,3767)=82.708, p&lt;.001].
Discussion: There are significant differences in rCBF between children and adults with high self-reported levels of anxiety. This indicates that different neuronal mechanisms in adults and children are involved when experiencing high levels of anxiety. These findings can help clinicians better understand differences in how anxiety is expressed neurologically between children and adults.
A-177 Relationship between Subjective Well-Being and Interpersonal Relationships in the sheltered workshop
Authors: Yamada Taigou , Okutani Ken , Hayashi Naoki 
Published: August 2022

Abstract
Objective: The purpose of this study was to examine the influence of social participation on subjective well-being, especially among those who used employment support facilities, based on the understanding of subjective well-being in inpatient and psychiatric day care settings.
Methods: Subjects were clinically stable individuals diagnosed with endogenous psychosis. A total of 40 individuals were hospitalized (n=14), in psychiatric day care (n=10), or in a supportive employment facility (n=16). There were 18 women. The Japanese version of the Short Version of the Subjective Well-being Scale under Antipsychotic Treatment (SWNS-J) was used to assess subjective well-being. The Brief Psychiatric Symptom Rating Scale (BPRS) was used to assess the severity of psychiatric symptoms. The WHO DAS2.0 Japanese version (WHODAS2.0) was used for the social life assessment scale. Spearman's rank correlation was used for statistical analysis.
Results: The SWNS-J scores for subjective well-being were 75.7 (standard deviation=21.2) for inpatient, 71.2 (±22.6) for psychiatric day care, and 68.2 (±15.3) for employment support facilities. In employment support facilities, relatively low correlations were found between the SWNS-J and the WHODAS2.0 sub-items such as "understanding and communication," "independence," "self-care," and "daily life (family)," especially in interpersonal relationships (getting along with others: ρ = -0.65, P &lt; 0.01) was significantly correlated with the SWNS-J.
Conculsion: The results suggest that it is important for occupational therapists to be aware of some daily stressors in interpersonal interactions when working with people in employment support facilities, and to give appropriate consideration to these stressors.
A-180 Clinical Outcome Following Concussion Among Children and Adolescents with a History of Prior Concussion: A Systematic Review
Authors: Cook Nathan E , Gaudet Charles E , Van Patten Ryan , Kissinger-Knox Alicia , Iverson Grant L 
Published: August 2022

Abstract
Purpose: This systematic review examined the association between prior concussion history and clinical outcomes following concussion among children and adolescents.
Data Selection: This review was registered with PROSPERO database for systematic reviews (protocol ID: CRD42016041479 & CRD42019128300) and adhered to PRISMA guidelines. Three searches of nine online databases were conducted: (a) database inception to June of 2016; (b) January 1, 2016 to February 1, 2019; and (c) February 1, 2019 to May 15, 2021. We screened 5,118 abstracts and 51 studies were reviewed. We utilized a likelihood heuristic to assess evidence for an association between concussion history and clinical outcomes. Risk of bias was assessed using the Newcastle-Ottawa scale and level of evidence was appraised using the Oxford Classification for Evidence-Based Medicine.
Data Synthesis: Concussion recovery or outcome was reported for 26,643 youth. A median of 36% had a prior history of concussion. Across all studies and outcomes, the majority (k=37, 72.5%) did not find a statistically significant association between lifetime history of concussion and outcome from a subsequent concussion. Important methodological limitations in the literature were identified (e.g., many studies were underpowered and/or coded prior concussion history as a binary variable as opposed to the number of prior concussions).
Conclusions: Available studies do not provide compelling evidence that children and adolescents with a history of concussions are at increased risk for worse clinical outcome following a subsequent concussion. Clinicians are cautioned against routinely treating children and adolescents with one or more prior injuries more conservatively. Doing so, in some cases, might be counterproductive.
A-188 The Effect of Traumatic Experiences on Identity Among People With Expressive Language Disorders
Authors: Wagaman Bailey , Berman Steven 
Published: August 2022

Abstract
Objective: To examine the effects of traumatic brain injury (TBI) on identity functioning.
Method: TBI survivors’ recollections of their sense of identity before and after they acquired a TBI were compared. Participants (N = 15, Mage = 52.67) recruited from rehabilitation and support groups completed two clinical interviews, as well as the Trauma Impacts of Identity Functioning Scales (Waterman, 2020) and Identity Distress Scale (Berman et al., 2004). They were mostly stroke survivors with aphasia. The majority of the participants were White (53.3%). The time since they acquired an expressive language disorder ranged from 2 to 21 years ago (M = 7.33).
Results: A paired samples t-test revealed a significant increase in identity distress from pre- to post-brain injury (t(14) = -3.11, p = .008, 95% CI). A ONEWAY ANOVA revealed that ratings of how important their career is to their sense of identity significantly decreased post-TBI (F(1, 13) = 17.47, p = .001, λ = .427, 95% CI). During the clinical interviews, many TBI survivors reflected that they lost a large part of themselves because they could no longer pursue their careers, and they experienced drastic changes in their relationships and life roles. Participants had identity development delays, trauma-centered identity, identity loss, identity threat, and identity affirmation.
Conclusion: Identity changes post-TBI varied greatly from one survivor to another, and time since trauma was not significantly correlated with identity functioning nor identity distress, suggesting the need for future research to determine which factors influence why TBI survivors’ experience post traumatic identity disruption and/or post-traumatic growth.
A-190 Posterior Electrode Angle Predicts Post-DBS Apathy Increases in Parkinson’s Disease Patients
Authors: Schmitt Taylor R , Hurd Zachery , Askari Asra , Patil Parag G , Chou Kelvin L , Persad Carol C 
Published: August 2022

Abstract
Objective: The literature has consistently shown that Parkinson’s disease (PD) patients tend to experience increases in apathy following deep brain stimulation of the subthalamic nucleus (STN-DBS). While surgical variables, i.e., active contact location and lead angle, have previously been found to predict post-DBS cognitive changes, it has yet to be studied whether these variables also impact post-DBS apathy.
Method: Data was retrospectively analyzed from 42 individuals with idiopathic PD who underwent bilateral STN-DBS. Forty-two individuals completed patient-report versions of the Marin Apathy Scale, and 27 had accompanying caregiver reports. Pearson’s correlations and linear regressions were conducted to examine the impact of active contact location (in X, Y, and Z axes) and lead angle (in anterior/posterior and medial/lateral directions) on post-DBS apathy changes. Covariates included disease duration, age, and change in motor symptoms (as measured by the MDS-UPDRS).
Results: Increases in caregiver-reported apathy post-DBS were explained by more posterior angles of the leads in both hemispheres (right: R2 = .33, F(3,23) = 3.79, p = .02, sr2 = .32; left: R2 = .37, F(3,23) = 4.56, p = .01, sr2 = .36). Although a significant correlation was identified between worse patient-reported apathy and more medial active contact location in the right hemisphere, this effect was no longer significant with inclusion of covariates.
Conclusions: Findings indicate that lead angle, but not active contact location, has a significant impact on post-DBS increase in apathy. This is consistent with prior studies predicting post-DBS verbal fluency changes and may suggest an adverse effect on frontostriatal neurocircuitry.
A-191 The Relationship between Demographic and Injury-Related Factors and Return to Driving following Holistic Milieu-Oriented Neurorehabilitation
Authors: Maffett Anissa , Klonoff Pamela , Johnson Spring , Roth-Roemer Sari , Koberstein Edward 
Published: August 2022

Abstract
Objective: Return to driving (RTD) following an acquired brain injury (ABI) positively impacts an individual’s productivity, quality of life, and community re-integration. Research illustrates that the return to driving is a complex process influenced by personal, cognitive, psychological, medical, neurological, and environmental factors. This study examined the association between demographic and injury factors and RTD at discharge following intensive neurorehabilitation.
Method: This retrospective study analyzed the medical records of 178 individuals with heterogeneous acquired brain injuries who participated in a holistic milieu-oriented outpatient neurorehabilitation program from 2012 to 2022. Demographic information (age, education, race/ethnicity), injury history (injury type, age at injury, chronicity), program participation variables (length of program participation, age at participation), and driving status at discharge were collected.
Results: Individuals with more chronic injuries were less likely to present with a RTD goal at admission, (p = .004). 71% (N = 88) of individuals met their RTD goal by discharge. There was no significant relationship between age at injury, age at admission, chronicity, days in treatment, or education and successful RTD at discharge. Type of brain injury (traumatic brain injury, stroke, or other [i.e., anoxia, seizure, and infection]), gender, and race/ethnicity were not related to successful RTD at discharge.
Conclusions: The majority of ABI survivors met their RTD goal at discharge. Findings illustrate that the holistic milieu-oriented treatment approach is effective with regard to addressing RTD goals across a variety of brain injury etiologies, demographics factors, and injury variables.