bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain state transition analysis using ultra-fast fMRI differentiates MCI from cognitively normal controls
Authors: Palmer William C. , Park Sung Min , Levendovszky Swati Rane 
Published: September 2022

PurposeConventional resting-state fMRI studies indicate that many cortical and subcortical regions have altered function in Alzheimer’s disease (AD) but the nature of this alteration has remained unclear. Ultrafast fMRIs with sub-second acquisition times have the potential to improve signal contrast and enable advanced analyses to understand temporal interactions between brain regions as opposed to spatial interactions. In this work, we leverage such fast fMRI acquisitions from Alzheimer’s disease Neuroimaging Initiative to understand temporal differences in the interactions between resting-state networks in 55 older adults with mild cognitive impairment (MCI) and 50 cognitively normal healthy controls.MethodsWe used a sliding window approach followed by k-means clustering. At each window, we computed connectivity i.e., correlations within and across the regions of the default mode, salience, dorsal attention, and frontoparietal network. Visual and somatosensory networks were excluded due to their lack of association with AD. Using the Davies–Bouldin index, we identified clusters of windows with distinct connectivity patterns, also referred to as brain states. The fMRI time courses were converted into time courses depicting brain state transition. From these state time course, we calculated the dwell time for each state i.e., how long a participant spent in each state. We determined how likely a participant transitioned between brain states. Both metrics were compared between MCI participants and controls using a false discovery rate correction of multiple comparisons at a threshold of. 0.05.ResultsWe identified 8 distinct brain states representing connectivity within and between the resting state networks. We identified three transitions that were different between controls and MCI, all involving transitions in connectivity between frontoparietal, dorsal attention, and default mode networks (p&lt;0.04).ConclusionWe show that ultra-fast fMRI paired with dynamic functional connectivity analysis allows us to capture temporal transitions between brain states. Most changes were associated with transitions between the frontoparietal and dorsal attention networks connectivity and their interaction with the default mode network. Although future work needs to validate these findings, the brain networks identified in our work are known to interact with each other and play an important role in cognitive function and memory impairment in AD.
Association between tea intake and hospitalized nephrolithiasis in Chinese adults: A case–control study
Authors: Liu Yingyu , Bi Shiyuan , Li Hexiao , Shi Jianxiu , Xia Yang , Niu Kaijun , Bai Song 
Published: September 2022

Introduction and aimNephrolithiasis is one of the most common urological disorders worldwide. Tea is one of the most popular drinks worldwide. This study aimed to explore the association between tea intake and hospitalized nephrolithiasis in Chinese adults.MethodsThe patients and healthy participants were from the Shenyang sub-cohort of Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study. After selecting and matching by age (±1 year) and sex using the 1:2 ratio, 834 participants were included in this study. Of these, 278 patients had hospitalized nephrolithiasis and 556 were healthy controls. The tea intake was assessed using a validated self-administered food frequency questionnaire. Multivariate conditional logistic regression analysis was used to evaluate the association between tea intake and hospitalized nephrolithiasis.ResultsAfter adjustment, a higher frequency of tea intake was found to be negatively associated with the risk of hospitalized nephrolithiasis. Compared with participants who never drank tea, the odds ratio (95% confidence interval) [OR (95% CI)] for participants who drank ≥1 cup (180 mL) of tea per day was 0.418 (0.192–0.911) (P for trend = 0.013). Moreover, the adjusted OR (95% CI) for participants who drank ≥1 cup of green tea and black tea per day was 0.189 (0.069–0.520) (P for trend &lt;0.001) and 1.248 (0.437–3.559) (P for trend = 0.654), respectively.ConclusionsIncreased tea intake was found to be associated with a lower risk of hospitalized nephrolithiasis among Chinese adults. This finding may assist in the prevention of hospitalized nephrolithiasis.
18F-FDG PET/CT radiomics nomogram for predicting occult lymph node metastasis of non-small cell lung cancer
Authors: Qiao Jianyi , Zhang Xin , Du Ming , Wang Pengyuan , Xin Jun 
Published: September 2022

PurposeTo investigate the ability of a PET/CT-based radiomics nomogram to predict occult lymph node metastasis in patients with clinical stage N0 non-small cell lung cancer (NSCLC).Materials and methodsThis retrospective study included 228 patients with surgically confirmed NSCLC (training set, 159 patients; testing set, 69 patients). ITKsnap3.8.0 was used for image(CT and PET images) segmentation, AK version 3.2.0 was used for radiomics feature extraction, and Python3.7.0 was used for radiomics feature screening. A radiomics model for predicting occult lymph node metastasis was established using a logistic regression algorithm. A nomogram was constructed by combining radiomics scores with selected clinical predictors. Receiver operating characteristic (ROC) curves were used to verify the performance of the radiomics model and nomogram in the training and testing sets.ResultsThe radiomics nomogram comprising six selected features achieved good prediction efficiency, including radiomics characteristics and tumor location information (central or peripheral), which demonstrated good calibration and discrimination ability in the training (area under the ROC curve [AUC] = 0.884, 95% confidence interval [CI]: 0.826-0.941) and testing (AUC = 0.881, 95% CI: 0.8031-0.959) sets. Clinical decision curves demonstrated that the nomogram was clinically useful.ConclusionThe PET/CT-based radiomics nomogram is a noninvasive tool for predicting occult lymph node metastasis in NSCLC.
Searches for long-lived particles at the future FCC-ee
Authors: Verhaaren C. B. , Alimena J. , Bauer M. , Azzi P. , Ruiz R. , Neubert M. , Mikulenko O. , Ovchynnikov M. , Drewes M. , Klaric J. , Blondel A. , Rizzi C. , Sfyrla A. , Sharma T. , Kulkarni S. , Thamm A. , Blondel A. , Suarez R. Gonzalez , Rygaard L. 
Published: September 2022

The electron-positron stage of the Future Circular Collider, FCC-ee, is a frontier factory for Higgs, top, electroweak, and flavour physics. It is designed to operate in a 100 km circular tunnel built at CERN, and will serve as the first step towards ≥100 TeV proton-proton collisions. In addition to an essential and unique Higgs program, it offers powerful opportunities to discover direct or indirect evidence of physics beyond the Standard Model. Direct searches for long-lived particles at FCC-ee could be particularly fertile in the high-luminosityZrun, where 5 × 1012Zbosons are anticipated to be produced for the configuration with two interaction points. The high statistics of Higgs bosons,Wbosons and top quarks in very clean experimental conditions could offer additional opportunities at other collision energies. Three physics cases producing long-lived signatures at FCC-ee are highlighted and studied in this paper: heavy neutral leptons (HNLs), axion-like particles (ALPs), and exotic decays of the Higgs boson. These searches motivate out-of-the-box optimization of experimental conditions and analysis techniques, which could lead to improvements in other physics searches.
Research on the influence of sports participation on school bullying among college students—Chain mediating analysis of emotional intelligence and self-esteem
Authors: Yiyi Ouyang , Jie Peng , Jiong Luo , Jinsheng Teng , Kun Wang , Jing Li 
Published: September 2022

PurposesThis paper aims to discuss the relationship between college students’ sports participation, school bullying, emotional intelligence and self-esteem. At the same time, it explores the intrinsic mechanisms of school bullying, in order to provide a reference for reducing bullying phenomenon among college students, and pave the way for college students to lead happy, healthy and confident lives.MethodsA total of 1,317 students (725 male students, 592 female students, 21.31 ± 3.28 years old) from four universities in Southwest China were selected as subjects for this survey. They were selected by stratified random sampling, and the data needed was obtained using a structured questionnaire. The data was subsequently processed with statistical software SPSS19.0 and AMOS21.0.Results(1) Sports participation has a significant and positive correlation with emotional intelligence and self-esteem, likewise, it has a significant negative correlation with school bullying. Emotional intelligence has a marked positive correlation with self-esteem, at the same time it has a significant negative correlation with school bullying. In addition, self-esteem is strongly negative correlated with school bullying. (2) Sports participation has a direct effect on school bullying (ES = −0.271). Emotional intelligence (ES = −0.144) and self-esteem (ES = −0.065) also play a significant mediating role between sports participation and school bullying, and the chain mediating force of emotional intelligence—self-esteem also reaches a significant level (ES = −0.016).ConclusionSports participation affects school bullying among college students not only directly but also indirectly, such as through emotional intelligence, the mediating role of self-esteem, and the chain mediating role of emotional intelligence to self-esteem. Apart from sports participation, emotional intelligence is another key factor that affects college students’ school bullying. Therefore, while attaching great importance to college students’ sport participation, schools should also provide courses aimed at developing students’ emotional intelligence.
Lifestyles of Spanish elders from supervened SARS-CoV-2 variant onwards: A correlational research on life satisfaction and social-relational praxes
Authors: Díaz-García Orlanda , Herranz Aguayo Inmaculada , Fernández de Castro Patricia , Ramos José Luis Gómez 
Published: September 2022

ObjectiveThis study aimed to analyze the influence and measurement of the relationship and interaction between the elderly lifestyles after the appearance of the SARS-CoV-2 variant and the factors analyzed comprised life satisfaction levels, social relationships, and daily-life activities.MethodsThe study population was ≥ 65 in Castile-La Mancha (N = 390,221). The research design was quantitative and arose from primary data collected via an ad hoc survey carried out through the Computer Assisted Telephone Interview system by randomly stratified sampling. The sample size was made up of 1,065 cases, and the participants were selected through a random sampling stratified by gender quotas (55.40% women; 44.60% men), age (x¯ = 76.56), province, and habitat size.ResultsThe results obtained revealed two main lifestyles, from which a notable behavioral change in personal relationships led to infer toward alternative lifestyles.ConclusionNotwithstanding the variation in lifestyles of the elderly after the pandemic, certain relationships remained unaltered. Thus, from the analyzed variables, relatives and friends relationships were scarcely influenced by the supervened incident.
Evaluating the role of SARS-CoV-2 target genes based on two nucleic acid assay kits
Authors: Zhu Xuetong , Zhou Fengyan , Zhou Qi , Xu Jiancheng 
Published: September 2022

BackgroundEffective isolation and early treatment of coronavirus disease 2019 (COVID-19) relies on rapid, accurate, and straightforward diagnostic tools. In response to the rapidly increasing number of cases, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) assays for multiple target genes have become widely available in the market.MethodsIn total, 236 COVID-19 patients with positive results in both RT-qPCR and rapid antigen diagnosis (Ag-RDT) were enrolled in the study. The cycle threshold (Ct) was compared with different onset times and target genes. Comparison between groups was evaluated with the Kruskal-Wallis test and Dunn test. The correlation between target genes was analyzed by Spearman.ResultsIn samples of Ct ≤ 21, Ct was different for the nucleocapsid (N), open reading frame 1ab (ORF1ab), and envelope (E) genes (P &lt; 0.05). Mild COVID-19 patients within 7 days of onset accounted for 67.80% of all enrolled patients. At the above stage, all target genes reached the trough of Ct, and N genes showed lower values than the other target genes. The Ct of the ORF1ab and N gene in asymptomatic patients differed from those of mild patients within 7 days and more than 14 days of onset. The kits used in the study showed strong consistency among target genes, with all correlation coefficients &gt;0.870.ConclusionRT-qPCR confirmed that the N gene performed well in Ct ≤ 21 and samples within 7 days of onset. Ag-RDT was discriminatory for patients within 7 days of onset. This study facilitated early identification and control of COVID-19 prevalence among patients.
Relationship between lymph nodes examined and survival benefits with postoperative radiotherapy in oral cavity squamous cell carcinoma patients with stage T1-2N1M0
Authors: Fan Sufeng , Jiang Wenmei , Fang Zhongyi , Li Ruiyu , Li Yudong , Chen Yanfeng , Zhang Quan 
Published: September 2022

BackgroundThis study aims to explore the relationship between the lymph nodes examined and survival benefits of postoperative radiotherapy in oral cavity squamous cell carcinoma patients with stage T1-2N1M0.MethodsThis study retrieved patients who underwent dissection of the primary site and neck lymph nodes for pT1-2N1M0 oral cavity squamous cell carcinoma without adverse nodal features from the Surveillance, Epidemiology, and End Results database from 2004 to 2015. Propensity score matching analysis was conducted, and the best cutoff value of the lymph nodes examined was determined by X-tile. Cancer-specific survival was the primary outcome. Univariable and multivariable analyses were performed to assess the relation between postoperative radiotherapy and cancer-specific survival, adjusting for other prognostic factors.ResultsA total of 469 patients were finally enrolled according to our exclusion criteria, and then 119 pairs of patients were matched by propensity score matching analysis. The best cutoff value of the lymph nodes examined was determined by X-tile, stratifying patients into lymph nodes examined ≤16 group and lymph nodes examined &gt;16 group. For the whole matched cohort, the choice of postoperative radiotherapy had no correlation with other factors (all p’s &gt; 0.05), and postoperative radiotherapy made no contribution to a better survival outcome for patients (p = 0.289). After stratified by the lymph nodes examined, in the lymph nodes examined ≤16 group, significantly improved CSS was found for those who undertook postoperative radiotherapy compared to those who just received surgery (unadjusted hazard ratio, 0.541; 95% confidence interval, 0.333–0.878; p = 0.013).ConclusionsOur study revealed that pT1-2N1M0 oral cavity squamous cell carcinoma patients were more likely to benefit from postoperative radiotherapy when unsatisfactory neck dissection was conducted, indicating that the number of lymph nodes examined might be a factor when clinicians do therapeutic planning for early-stage oral cavity squamous cell carcinoma patients.
Comparison of clinical safety and feasibility between reduced-port laparoscopic radical gastrectomy and conventional laparoscopic radical gastrectomy: A retrospective study
Authors: Wang Liang , Deng Yingfang , Yan Su , Ma Xinfu , Wang Cheng , Miao Wei , Chen Xiaoqian 
Published: September 2022

BackgroundTraditional open gastric cancer surgery has evolved from porous to reduced-hole, single-hole, or even natural cavity surgery to laparoscopic surgery, due to the continuous development of minimally invasive concepts and medical technologies, as well as awareness for the concept of rapid recovery. Conventional laparoscopic radical gastrectomy is quite mature in age at the moment, but how to progress to minimally invasive surgery without increasing the difficulty of surgery while ensuring clinical safety and feasibility is worth further investigation. Therefore, the clinical safety and feasibility of reduced port laparoscopic radical gastrectomy were assessed in this study.MethodsInformation on the clinical data of patients undergoing laparoscopic radical gastric cancer surgery in a single centre between May 2020 and May 2022 was collected, and a total of 232 patients were included in this study according to the study protocol design. The clinical data of 232 patients with gastric cancer treated by two different surgical methods, namely, reduced port laparoscopic surgery (RPLS) or conventional laparoscopic surgery (CLS), were retrospectively analysed. The intraoperative indices, postoperative pathological indices, and short-term postoperative complications (within 30 days) of the two different surgical methods were evaluated, as well as the surgical methods’ feasibility and short-term postoperative recovery effect.ResultsThere was no significant difference between the general data of patients with RPLS and CLS (P &gt; 0.05). Compared with CLSG, the operation time, digestive tract reconstruction time and lymph node dissection time of RPLSG are shorter. The intraoperative blood loss was less, and the incision was minimally invasive (P &lt; 0.05). In the short-term postoperative effect, the level of white blood cell count on the first day, the time of getting out of bed, the time of removing drainage tube, the time of hospitalization and the VAS of pain on the first, third and fifth days after operation, RPLSG was obviously superior to CLSG (P &lt; 0.05). There was no significant difference between RPLSG and CLSG in terms of pathological indices (P &gt; 0.05).ConclusionsThe treatment of gastric cancer with RPLS has good safety, feasibility and short-term postoperative effects, which is in line with the implementation of the modern concept of rapid rehabilitation surgery.
Impact of Utilitarian and Hedonic Values on Hijab Buying Intentions: Evidence from Indonesia
Authors: Najib Moh Farid , Fauziah Tia , Djatnika Tjetjep , Saefulloh Dedy , Purnamasari Dewi 
Published: September 2022

Hijab has become a necessity for Muslim female customers. Hijab products are various as they are used not only as a cover but also increase their confidence since hijab fashion does not have to be left behind by non-hijab fashion. The interest in buying a premium hijab may be due to its utilitarian or hedonic nature. This paper examines the differences between the importance of utilitarian and hedonic values on evidence of buying intention of hijab from Indonesia. This research employs explanatory research by collecting 400 Muslim female respondents in West Java. The data processing method uses a scoring with a Likert scale. The structural Equation Model (SEM) is used to analyze the data by applying SEM-PLS. The results show that both the utilitarian values and the hedonic values simultaneously do not affect the buying intention. Instead, they partially give a significant effect on the buying intention. This could be translated that Muslim women in Indonesia are competing in seeking the values of their faith and need emotional satisfaction in their daily activities.
Analysis of the Impact of Covid-19 on Pregnant Women on Preparation for Childbirth
Authors: Irnawati  , Salmiani Abdul Manaf  
Published: September 2022

All routine services, including maternal and newborn health services, face many constraints during this pandemic. In the early stages of pregnancy, almost every pregnant woman begins to prepare for labor. There are many things that can be done to prepare, from preparing for the needs of the baby, the needs of the mother, psychological preparation, to preparing for the choice of a birthing facility. Welcoming babies into families is a habit, but during the Covid-19 pandemic, it's another story. Objective: The purpose of this Systematic Review is to analyze the effect of immunization services during the COVID-19 pandemic. Methods: Database search includes Google Scholar, Science Direct, and Pubmed with the keywords used are impact, anxiety; pregnant mother; maternity mother; childbirth, pandemic, COVID-19. The next stage is to select articles according to the criteria, which are published in 2017-2022 with the full text of 12 articles that meet the inclusion criteria. Results: Findings from 12 articles showed that the impact of COVID-19 on the preparation of pregnant women for childbirth in health facilities differed from maternal anxiety. In addition, the anxiety of pregnant women about childbirth greatly affects the mother's readiness to carry out prenatal care and preparation for delivery. And the effects of Covid-19 on childbirth have not been shown to be contagious to the newborn. However, mothers who are infected with Covid-19 must still follow health protocols, including self-isolation or separation from their newborn babies. Conclusion: the impact of covid 19 on preparation for childbirth is the anxiety of pregnant women, This anxiety can be reduced by providing guidance, counseling and education for pregnant women about transmission and routes of transmission. How to protect yourself from COVID-19 and its prevention. It is transmitted from pregnant women to babies. More importantly, if the mother is hesitant and afraid to go for a pregnancy check-up at the hospital for fear of contracting the virus from other people, a solution can be given to check her womb at the nearest midwife or clinic so that she can avoid contact with other people as well as when the delivery process arrives.
Gender-Based Multigroup Analysis on the Mediating Role of Online Learning Self Efficacy to The Influence of Academic Interaction to Student Engagement
Authors: Prajogo Wisnu , Tjandra Ronowati , Yandra Fachmi Pachlevi , Astuti Ratna Puji 
Published: September 2022

All schools and Universities in Indonesia have to implement online learning due to covid19 issue. This article examines gender as group moderator to the mediating role of online learning self efficacy (OLSE) to the influence of academic interaction to student engagement in e-learning system in Indonesia. This uses higher order construct of academic interaction comprising student-studentÂ interaction (SSI) and student-lecturer interaction (SLI), and also higher order construct of student engagement comprising agentic (AE), emotional (EE), cognitive (CE), and behavioral (BE) engagement.Â 378 students from several online classes participated in this research. This research found that academic interaction has positive influence to student engagement, academic interaction has positive influence to studentsâ€™ online learning self efficacy, and studentsâ€™ online learning self efficacy has positive influence to student engagement. This research also found that online learning self efficacy partially mediates the influence of academic interaction to student engagement and gender moderates all relationships in the researchÂ model.