bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytohormones Regulate the Non-redundant Response of ω-3 Fatty Acid Desaturases to Low Temperatures in Chorispora bungeana
Authors: Shi Yulan , Yang Sizhong , Yue Xiule , Zhao Zhixing , An Lizhe 
Published: June 2022

Abstract
Key message The cold-induced expression of ω-3 CbFAD genes were mainly regulated by jasmonie acid and brassinosteroid, and the accumulation of TAs below 0 ℃ was due to the contribution of CbFAD8 To explore the contributions of ω-3 fatty acid desaturases (FADs) to cold stress response in a special cryophyte, Chorispora bungeana (C. bungeana), two plastidial ω-3 FAD genes (CbFAD7 and CbFAD8) were cloned and verified in an Arabidopsis fad7fad8 mutant, before being compared with the microsomal ω-3 FAD gene (CbFAD3) on expression profile. Though these genes were expressed in all tested tissues of C. bungeana, CbFAD7 and CbFAD8 have the highest expression in leaves, while CbFAD3 was mostly expressed in suspension-cultured cells. Low temperatures (4, 0 and -4 ℃) resulted in significant increases in trienoic fatty acids (TAs, mainly C18:3), which were consisted with the cooperation of CbFAD3 and CbFAD8 in cultured cells, and the coordination of CbFAD7 and CbFAD8 in leaves. Furthermore, the cold induction of CbFAD8 in the two tissues were increased with decreasing temperature and independently contributed to TAs accumulation at -4 ℃. A series of experiments revealed that jasmonie acid and brassinosteroids participated in the cold-responsive expression of ω-3 CbFAD genes in both C. bungeana cells and leaves, while the phytohormone regulation in leaves was more complicated with the participation of abscisic acid and gibberellin. These results point to the hormone-regulated non-redundant contributions of ω-3 CbFADs to maintain appropriate level of TAs under low temperatures, which helps C. bungeana survive in cold environments.
Molecular identification and phylogenetic analysis of free-living amoeba in the water resources of Arak, Iran
Authors: Fani Malihe , Fuerst Paul A. , Mosayebi Mahdi , Javadi Amir , Harandi Majid Fasihi , Saraei Mehrzad , Badri Milad , Hajialilo Elham 
Published: June 2022

Abstract
The aim of the present study was to detect free-living amoeba (FLA) in the water resources of Arak, Iran using molecular tools. A total of 154 samples were collected from different water supplies. Molecular analyses, sequencing, and phylogenetic study were conducted to confirm the species and genotypes of FLA. Fisher exact test was used to determine the significance. Of 154 water samples, 19 (12.3%) samples were tested positive for FLA. Three genotypes of Acanthamoeba including T4, subtype D, and T5 were identified among the isolates. The pathogenicity assay showed that the isolate of Acanthamoeba in drinking water was highly pathogenic. Three species of Naegleria, including N. australiensis, N. pagei, and N. gruberi were found among the samples. Six isolates of Vermamoeba were identified as V. vermiformis. Meanwhile, three other species including Vannella sp., Vahlkampfia avara, and Stenamoeba polymorpha were also recovered from the water samples. Statistical analysis showed a significant difference between the various water resources contaminated with FLA. This is the first study to reveal the presence of S. polymorpha in water sources in Iran. According to the findings of the present study, health officials should be beware of potential public health impacts of FLA in water resources.
Identification of the water source and groundwater recharge in a paddy field using stable hydrogen and oxygen isotopes
Authors: Chou Mon-Lin , Tseng Hong-Yang , Wang Chung-Ho , Hseu Zeng-Yei 
Published: June 2022

AbstractThe stable isotopes of oxygen-18 and deuterium were utilized to identify different water sources mixing in the soil layer that recharged to groundwater of a paddy field during the growth season in 2014. Based on the measurements of deuterium and oxygen-18 in soil water, rainwater and groundwater in the paddy field of Chianan Plain in Southwest Taiwan in the wet season was collected, and the relationship between δD and δ18O in soil water and groundwater recharge was investigated in this study. The soil water in the paddy field of Chianan plain was collected with suction lysimeters for the identification of different sources of subsurface flow. The isotopic compositions of hydrogen and oxygen in different water bodies were used to evaluate the groundwater recharge sources in the paddy field. The intensity of rainfall and evaporation influenced the saturation conditions of pore water present in the soil layer. In general, transiently intense rainfall tended to be difficult in recharging groundwater. The results show the use of stable isotopes in water bodies can be used to monitor or identify the source/sink of soil layer and their respective contributions to groundwater recharge. In this research, the isotopic compositions of hydrogen and oxygen in the soil water at different depths before and after event water were identified. The top soil layer (&lt;30 cm depth) in the presence of the isotope depleted soil water was probably subjected to evaporation. The soil water has more depleted isotope composition that was observed in shallow soil layers. More depleted fraction of isotopes in groundwater was similar to rainwater, which suggested that the groundwater was primarily from rainfall. In addition, the isotopic compositions of hydrogen and oxygen in groundwater slightly deviated from the local meteoric water line in southern Taiwan.
Anomalous Migration of Horse Erythrocyte Spectrin Dimers in Native Polyacrylamide Gels
Authors: Bobich Joseph A. , Walli Cleatus J. 
Published: June 2022

Abstract:
A novel property of equine erythrocyte spectrin permits visualization of two forms of the dimer on natite
polyacrylamide gels. This is not due to membrane extraction temperature, protein phosphorylation state, Ca2+
binding, homodimer formation, or endogenous proteolysis. The less hydrophobic (dimer2) conformer is more
susceptible to cleavage by endogenous and exogenous protease, suggesting that dimerl and dimer2 represent closed and open conformers, respectively.
Application of Artificial Intelligence in Drug Discovery
Authors: Chopra Hitesh , Baig Atif A. , Gautam Rupesh K. , Kamal Mohammad A. 
Published: June 2022

Abstract:Due to the heap of data sets available for drug discovery, modern drug discovery has taken the shape of big data. Usage of Artificial intelligence (AI) can help to modify drug discovery based on big data to precised, knowledgeable data. The pharmaceutical companies have already geared their departments for this and started a race to search for new novel drugs. The AI helps to predict the molecular structure of the compound and its in-vivo vs. in-vitro characteristics without hampering life, thus saving time and economic loss. Clinical studies, electronic records, and images act as a helping hand for the development. The data mining and curation techniques help explore the data with a single click. AI in big data analysis has paved the red carpet for future rational drug development and optimization. This review's objective is to familiarise readers with various advances in the AI field concerning software, firms, and other tools working in easing out the labor of the drug discovery journey.
Gastroretentive Drug Delivery System in Cancer Chemotherapy
Authors: Rath Goutam , Anothra Pooja , Pradhan Deepak , Halder Jitu , Ghosh Goutam 
Published: June 2022

Background:
Chemotherapy for stomach cancer often includes several side effects. The primary
reasons for the failure of such treatment approaches are low drug concentrations in target tissues
and a short stomach residence time.

Objective:
Gastroretentive controlled drug delivery systems improves the therapeutic performance of
chemotherapeutic drugs following oral administration because of the longer gastric retention time. The
goal of this study was to find suitable gastroretentive formulations that might be used for the localized
treatment of stomach cancer.

Method:
The purpose of this study is to summarize current advances in gastro-retentive drug administration
for oral chemotherapy, with a focus on floating, mucoadhesive, and swellable systems. This
article also discusses the potentials and limitations of existing gastroretentive drug delivery systems
used in cancer chemotherapy.

Result:
Due to increased stomach retention and modified drug release properties, gastroretentive controlled
drug delivery systems improve the therapeutic performance of anti-cancer drugs used to treat
stomach cancer.

Conclusion:
Gastroretentive drug delivery systems appear to be a promising carrier for localized chemotherapy
with smaller doses and better patient compliance. However, selection of drug candidates, drugfood
interactions and chemotherapy-induced gastric discomfort remain the key characteristics that must
be addressed to improve treatment outcomes.
The Potential Effect of Blueberry on Cognitive Health and Mood State
based on Human Intervention Studies: Systematic Review and Mini
Meta-Analysis
Authors: Soveid Neda , Barkhidarian Bahareh , Moradi Sajjad , Gholami Fatemeh , Rasaei Niloufar , Himmerich Hubertus , Mirzaei Khadijeh 
Published: June 2022

Background:
Blueberries are known for their high content of several bioactive compounds,
specifically anthocyanin, which are the most beneficial of the flavonoid family in terms of neuroprotection.
Several human interventional studies have been conducted to assess the effects of blueberry
intake on cognitive performance; however, the results of clinical trials are inconclusive. Therefore, this
systematic review and meta-analysis evaluated the effect of blueberry supplementation on some aspects
of cognitive performance and mood parameters using data from clinical trials based on existing
evidence.

Methods:
Relevant studies, published in April 2021, were searched through PubMed/Medline, Scopus,
Embase, and Google Scholar. The random effect size was used to estimate the pooled effect size. Heterogeneity
between studies was evaluated by the Cochrane Q test and I-squared (I2). To detect the
potential source of heterogeneity, a subgroup analysis was conducted.

Results:
Fourteenrandomized trials were included in the quantitative analysis, and six were pooled
for statistical analysis. Blueberry intervention resulted in no significant change in mood state score
(WMD = 0.03; 95% CI:-0.80 to 0.87, P = 0.16). Moreover, no significant effect of blueberry intake
was shown in attention task reaction time (WMD = -1.50 ms; 95% CI:-24.75 to -21.75, P = 0.9), percentages
of attention task accuracy (WMD = 0.85; 95% CI:-2.57 to 0.86, P = 0.3), one-back test accuracy
(WMD = 0.03; 95% CI:-0.04 to 0.09, P = 0.4). Significant effect was indicated (WMD = 0.08;
95% CI: 0.02 to 0.13, P = 0.005) in two-back test accuracy.

Conclusion:
We found a significant effect of blueberry consumption on two-back test accuracy as a
cognitive outcome. More high-quality clinical trials according to the challenges mentioned seem to indicate
the use of blueberry as a supplement for cognitive and mood health efficiently.
Edukasi Hukum tentang Kekerasan Seksual Pada Perempuan Dan Anak Di Kelurahan Lateri Kota Ambon
Authors: Saimima Judy Marria , Liminanto Elvira , Wasia Zacilasi 
Published: June 2022

Kekerasan seksual yang terjadi pada seorang perempuan dan anak dikarenakan sistem tata nilai yang mendudukan perempuan dan anak sebagai makhluk yang lemah dan lebih rendah dibandingkan laki-laki. Sangat diperlukan pemahaman hukum yang baik kepada masyarakat terkait kekerasan seksual agar mampu untuk bertindak ketika mengalami kekerasan seksual. Kegiatan ini dilakukan dengan mengidentifikasi masalah yang ada di daerah tersebut, kemudian masyarakat diberikan pemahaman demi meningkatkan kesadaran hukum tentang kekerasan seksual pada perempuan dan anak. Suatu perbuatan dapat dikategorikan sebagai kekerasan seksual adalah ketika perbuatan tersebut dilakukan tanpa ada persetujuan atau tidak dikehendaki. Undang-Undang PKDRT, UU Perlindungan Anak, KUHP bahkan UU Pornografi memang telah mengatur perlindungan bagi korban kekerasan seksual terhadap anak dan perempuan, namun itu belum cukup untuk bisa melindungi korban, karena perlindungan kekerasan seksual bukanlah terbatas pada teori dan peraturan tetapi lebih meluas lagi kepada kesadaran masyarakat sebagai makhluk sosial itu sendiri.

Legal Education On Sexual Violence Against Women And Children In Lateri Village, Ambon City
Sexual violence that occurs to a woman and child is due to a value system that places women and children as weak and inferior beings compared to men. It is necessary to have a good legal understanding of the community regarding sexual violence so that they are able to act when experiencing sexual violence. This activity is carried out by identifying the problems that exist in the area, then the community is given an understanding in order to increase legal awareness about sexual violence against women and children. An act that can be categorized as sexual violence is when the act is carried out without consent or is not desired. The PKDRT Law, the Child Protection Law, the Criminal Code and even the Pornography Law have indeed regulated protection for victims of sexual violence against children and women, but that is not enough to protect victims, because sexual violence protection is not limited to theories and regulations but is more broadly applicable to awareness of society as a social being itself.
Sosialisasi Program Aplikasi SIMAM: Upaya Inventarisasi Aset Pimpinan Cabang Muhammadiyah Bululawang
Authors: Luthfi Muhammad , Hartini Rahayu 
Published: June 2022

Muhammadiyah sebagai salah satu organisasi filantropi Islam dengan ragam aset yang dimiliki, mencanangkan program manajemen aset melalui aplikasi SIMAM, program ini menyasar seluruh aset yang berada pada setiap unsur pimpinan dan amal usaha yang dimiliki Muhammadiyah, berkenaan dengan hal tersebut maka dilakukan sosialiasi program aplikasi SIMAM di salah satu unsur pimpinan Muhammadiyah di kecamatan Bululawang. Tujuan pelaksanaan kegiatan, untuk memberikan pengetahuan dan pemahaman tentang program aplikasi SIMAM. Metode sosialisasi digunakan dalam kegiatan dengan pendekatan klasikal berupa pemberian pertanyaan pre-test, ceramah / presentasi, diskusi / tanya jawab, dan pemberian pertanyaan post-test. Hasil kegiatan menyatakan, sebelum kegiatan dilakukan Mitra kebanyakan belum mengatahui tentang program SIMAM hal ini diketahui dari hasil jawaban pre-test yang di berikan, berdasar dari hasil jawaban pre-test Tim Pengabdi memberikan 3 materi meliputi, konsep program SIMAM, tujuan program SIMAM, dan jenis kehartabendaan yang dimaukkan pada program SIMAM. Dampak kegiatan yang dihasilkan dari kegiatan ini Mitra mengetahui dan memahami program aplikasi SIMAM, hal ini di buktikan dengan jawaban dari pertanyaan post-test yang didapat Tim Pengabdi di mana seluruh peserta mengetahui dan memahami program aplikasi SIMAM.

SIMAM Application Program Socialization: Efforts to Inventory Assets for Muhammadiyah Bululawang Branch Managers
Muhammadiyah as one of the Islamic philanthropic organizations with a variety of assets owned, launched an asset management program through the SIMAM application, this program targets all assets located in every element of muhammadiyah's leadership and business charity, in this regard to this, the socialization of the SIMAM application program is carried out in one of the muhammadiyah leadership elements in Bululawang subdistrict. The purpose of carrying out activities, is to provide knowledge and understanding of the SIMAM application program. Socialization methods are used in activities with a classic approach in the form of giving pre-test questions, lectures/presentation, discussions / Q&A, and giving post-test questions. The results of the activity stated before the activity was carried out, most partners did not know about the SIMAM program, this was known from the results of the pre-test answers given, based on the results of the pre-test answers the Pengabdi Team gave 3 materials including, the concept of the SIMAM program, the purpose of the SIMAM program, and the type of treasures in the SIMAM program. The impact of the activities resulting from this activity, the Partner knows and understands the SIMAM application program, this is evidenced by the answers to post-test questions obtained by the Pengabdi Team where all participants know and understand the SIMAM application program.
Teorías y modelos de la interacción y la comunicación para espacios educativos a distancia
Authors: Ulloa-Brenes Gilbert 
Published: June 2022

Esta revisión bibliográfica tuvo por objetivo analizar las características e implicaciones pedagógicas de cinco modelos y teorías de la interacción y la comunicación, formulados en las últimas décadas por diferentes autores, cuyos aportes para la educación a distancia han sido de especial interés en este ámbito educativo. Para ello se efectuó una indagación de tipo bibliográfica en diferentes bases de datos y buscadores online, que permitiera ubicar literatura especializada, pero, sobre todo, apelando a la revisión de textos escritos por autores que propusieron originalmente el modelo o teoría, con lo cual se aporta un corpus de textos que pueden servir de consulta para futuras investigaciones.
Entre los principales hallazgos se destaca que cada uno de los enfoques analizados ha estado marcado por la evolución tecnológica propia de su contexto histórico; por lo tanto, como una de las principales conclusiones, se plantea que en el devenir de esas teorías se percibe una episteme arraigada a modos históricos de interacción pedagógica y a las mediaciones que marcaban esas concreciones.
Changing gears along 1050 m-3070m: shifting plant leaf anatomical strategic spectra of 286 plants in the eastern Qinghai-Tibet Plateau
Authors: Chong Peifang , Yang Jun , Chen Guo-peng , Yue Yifan 
Published: June 2022

Leaf anatomical traits can reflect plant adaptation to environmental
changes. However, whether the trade-offs among leaf anatomical traits
can reflect the strategies spectrum of plant response to environmental
changes and the strategic spectrum will shift with altitudes are not
clear. In this study, 286 plant species from 19 altitudinal gradients
from 1050 m to 3070 m on the eastern Tibetan Plateau were selected and
16 anatomical characters of blade, mesophyll and midrib were measured.
The strategic and strategic spectra of leaf anatomical trait formation
were by principal components analysis, followed by generalized additive
models of the strategic spectra with shift in elevation to test the
shift of strategy spectra along altitudes. Our results showed that the
midrib xylem thickness of woody increased with increasing altitude,
while other traits decreased; the upper and lower epidermis width,
midrib parenchyma cell thickness and midrib lower epidermis cell
thickness of herb increased with increasing altitudes, while other
traits decreased. Blade strategic spectrum (BES), blade and mesophyll
strategic spectrum (BMSS) and midrib strategic spectrum (MSS) were
formed in the tissue of leaves, and the score of principal component one
(PC1) was not significant between herbs and woody plants (
P>0.05). There were mainly formed the spectrum of
conservation and support strategies and the spectrum of resource
acquisition and consumption, etc. With increasing altitudes, the habitat
tended to become unsuitable for plant growth and the resources available
to plants are reduced, plants shift from a “invest-fast-reap”
acquisition strategy to a “invest-slow-reap” conservative strategy.
Revenue Recognition and Sales Return Issues at Medicis Corporation
Authors: Gross Andrew D. , Hemker Jeffrey , Hoelscher Jamie L. , Reed Brad J. , Sierra Gregory 
Published: June 2022

ABSTRACT
Sales returns are often considered a simple financial accounting topic, but in this case, accounting for sales returns led to a significant lawsuit and the largest fine ever imposed against a CPA firm by the PCAOB at the time. This case study is designed to aid instructors in teaching accounting for sales with right of return under ASC 606 and is suited for an intermediate financial accounting course or a graduate course in accounting research. Students are required to exercise higher-order skills, such as professional research and analysis, as they research and understand the following: (1) the FASB's prior revenue recognition guidance when a right of return exists (ASC 605) and the FASB's new revenue recognition guidance ASC 606; (2) the financial statement impact of alternative methods of accounting for sales returns; and (3) how to account for unique return policies, such as a return for expiration.
Accounting Academics' Perceptions of 12 Research Journals
Authors: Burton F. Greg , Heninger William G. , Summers Scott L. , Wood David A. 
Published: June 2022

ABSTRACT
This paper reports perceptions of over 1,000 accounting faculty regarding 12 accounting journals, specifically in how open they are to: (1) diverse topic areas, (2) diverse research methodologies, how effectively they produce new and useful knowledge for (3) non-academic stakeholders, and (4) academics. We find that the traditional Top 6 journals do not lead the academy along these four dimensions; in fact, some are viewed as the worst performers in these areas. Furthermore, we find that academics have a relatively poor understanding of the actual diversity of several journals. We also report how the academy perceives each journal's current value and how each journal should be valued when evaluating faculty on research productivity. We find that respondents believe the traditional Top 6 journals are and should continue to be weighted highly in faculty evaluation, but that the other journals should receive greater weighting.
The SNAP Cycle and Diabetes Management During a One-Time Change in Disbursement Schedule
Authors: Young Sabrina K. , Atwood Alicia , Allen Lindsay , Pauly Nathan 
Published: June 2022

OBJECTIVE
The 2018–2019 federal government partial shutdown resulted in a one-time disruption to the usual disbursement schedule of Supplemental Nutrition Assistance Program (SNAP) benefits nationwide. We assessed the relationship between this disruption and hyperglycemia and hypoglycemia medical encounters among beneficiaries with diabetes.

RESEARCH DESIGN AND METHODS
To estimate whether the one-time change in benefit disbursement affected the monthly cycle of hyperglycemia or hypoglycemia encounter rates, we used linked administrative Medicaid claims and SNAP disbursement data from West Virginia in a fixed-effects model with interactions between week of the month and the two months of interest—January and February 2019. We controlled for week, month, year, and county effects as well as individual characteristics, and we clustered SEs by individual.

RESULTS
We found that the early disbursement of SNAP benefits in January 2019 resulted in a spike in hyperglycemia four times the rate in a typical month. Further, we found a decrease in both hyperglycemia and hypoglycemia in late February.

CONCLUSIONS
Our findings suggest that the early distribution of benefits led to a temporary increase in food consumption among West Virginia Medicaid beneficiaries with diabetes. Findings from late February also imply that individuals may have a way to prepare for reduced food resources. These results shed new light on the effects of unexpected changes to the timing of safety net payments as well as an understanding of unintended consequences of government shutdowns.