bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Reflective Automated e-Coaching Can Help Employees Improve Their Capacity for Resilience: Mixed Methods Study
Authors: Lentferink Aniek , Oldenhuis Hilbrand , Velthuijsen Hugo , van Gemert-Pijnen Lisette 
Published: August 2022

Background
An eHealth tool that coaches employees through the process of reflection has the potential to support employees with moderate levels of stress to increase their capacity for resilience. Most eHealth tools that include self-tracking summarize the collected data for the users. However, users need to gain a deeper understanding of the data and decide upon the next step to take through self-reflection.

Objective
In this study, we aimed to examine the perceived effectiveness of the guidance offered by an automated e-Coach during employees’ self-reflection process in gaining insights into their situation and on their perceived stress and resilience capacities and the usefulness of the design elements of the e-Coach during this process.

Methods
Of the 28 participants, 14 (50%) completed the 6-week BringBalance program that allowed participants to perform reflection via four phases: identification, strategy generation, experimentation, and evaluation. Data collection consisted of log data, ecological momentary assessment (EMA) questionnaires for reflection provided by the e-Coach, in-depth interviews, and a pre- and posttest survey (including the Brief Resilience Scale and the Perceived Stress Scale). The posttest survey also asked about the utility of the elements of the e-Coach for reflection. A mixed methods approach was followed.

Results
Pre- and posttest scores on perceived stress and resilience were not much different among completers (no statistical test performed). The automated e-Coach did enable users to gain an understanding of factors that influenced their stress levels and capacity for resilience (identification phase) and to learn the principles of useful strategies to improve their capacity for resilience (strategy generation phase). Design elements of the e-Coach reduced the reflection process into smaller steps to re-evaluate situations and helped them to observe a trend (identification phase). However, users experienced difficulties integrating the chosen strategies into their daily life (experimentation phase). Moreover, the identified events related to stress and resilience were too specific through the guidance offered by the e-Coach (identification phase), and the events did not recur, which consequently left users unable to sufficiently practice (strategy generation phase), experiment (experimentation phase), and evaluate (evaluation phase) the techniques during meaningful events.

Conclusions
Participants were able to perform self-reflection under the guidance of the automated e-Coach, which often led toward gaining new insights. To improve the reflection process, more guidance should be offered by the e-Coach that would aid employees to identify events that recur in daily life. Future research could study the effects of the suggested improvements on the quality of reflection via an automated e-Coach.
Uncertainty Estimation in Medical Image Classification: Systematic Review
Authors: Kurz Alexander , Hauser Katja , Mehrtens Hendrik Alexander , Krieghoff-Henning Eva , Hekler Achim , Kather Jakob Nikolas , Fröhling Stefan , von Kalle Christof , Brinker Titus Josef 
Published: August 2022

Background
Deep neural networks are showing impressive results in different medical image classification tasks. However, for real-world applications, there is a need to estimate the network’s uncertainty together with its prediction.

Objective
In this review, we investigate in what form uncertainty estimation has been applied to the task of medical image classification. We also investigate which metrics are used to describe the effectiveness of the applied uncertainty estimation

Methods
Google Scholar, PubMed, IEEE Xplore, and ScienceDirect were screened for peer-reviewed studies, published between 2016 and 2021, that deal with uncertainty estimation in medical image classification. The search terms “uncertainty,” “uncertainty estimation,” “network calibration,” and “out-of-distribution detection” were used in combination with the terms “medical images,” “medical image analysis,” and “medical image classification.”

Results
A total of 22 papers were chosen for detailed analysis through the systematic review process. This paper provides a table for a systematic comparison of the included works with respect to the applied method for estimating the uncertainty.

Conclusions
The applied methods for estimating uncertainties are diverse, but the sampling-based methods Monte-Carlo Dropout and Deep Ensembles are used most frequently. We concluded that future works can investigate the benefits of uncertainty estimation in collaborative settings of artificial intelligence systems and human experts.

International Registered Report Identifier (IRRID)
RR2-10.2196/11936
Effects of a Mindfulness Intervention Comprising an App, Web-Based Workshops, and a Workbook on Perceived Stress Among Nurses and Nursing Trainees: Protocol for a Randomized Controlled Trial
Authors: Schönfeld Simone , Rathmer Ines , Michaelsen Maren M , Hoetger Cosima , Onescheit Miriam , Lange Silke , Werdecker Lena , Esch Tobias 
Published: August 2022

Background
Previous research has found digitally supported mindfulness interventions to be effective when used for stress management among workers in high-stress occupations. Findings on digitally supported mindfulness interventions among nurses working in acute inpatient care settings are heterogeneous, lack long-term follow-up, and do not assess adherence and acceptability.

Objective
This study aimed to investigate the effectiveness and efficacy of a digitally supported mindfulness intervention designed to improve health- and work-related outcomes among nurses and nursing trainees working in acute inpatient care settings.

Methods
We will conduct a multicenter randomized controlled trial using a wait-list control group design. Randomization will be stratified by hospital and job status (nurse or nursing trainee). Recruitment will take place on the web and offline during the working hours of nurses and nursing trainees. The intervention group will receive a digitally supported mindfulness intervention, which will comprise an app, 2 web-based workshops, and a workbook, whereas the wait-list control group will be scheduled to receive the same intervention 14 weeks later. The 2 web-based workshops will be led by a certified mindfulness-based stress reduction trainer. Nurses will use the app and the workbook independently. Self-report web-based surveys will be conducted on the web at baseline, at 10 weeks after allocation, at 24 weeks after allocation, and at 38 weeks after allocation. Outcomes of interest will include perceived stress (primary outcome), health- and work-related variables, and variables related to adherence and acceptability of the digitally supported mindfulness intervention. We will perform intention-to-treat and per-protocol analyses.

Results
Data collection will be completed by the beginning of August 2022. Data analyses will be completed by December 2022.

Conclusions
Our study design, including long-term follow-up and the investigation of variables related to adherence and acceptability, will ensure rigorous evaluation of effectiveness and efficacy. Relative to costly in-person intervention efforts, this program may present a cost-effective and potentially highly scalable alternative. Findings regarding effectiveness, efficacy, adherence, and acceptability will inform stakeholders’ decisions regarding the implementation of similar interventions to promote the well-being of nurses and nursing trainees, which may, in turn, alleviate detrimental stress-related outcomes (eg, burnout) because of work-related demands.

Trial Registration
German Clinical Trials Register DRKS00025997; https://tinyurl.com/433cas7u

International Registered Report Identifier (IRRID)
DERR1-10.2196/37195
A Mobile App Leveraging Citizenship Engagement to Perform Anonymized Longitudinal Studies in the Context of COVID-19 Adverse Drug Reaction Monitoring: Development and Usability Study
Authors: Di Filippo Marzia , Avellone Alessandro , Belingheri Michael , Paladino Maria Emilia , Riva Michele Augusto , Zambon Antonella , Pescini Dario 
Published: August 2022

Background
Over the past few years, studies have increasingly focused on the development of mobile apps as complementary tools to existing traditional pharmacovigilance surveillance systems for improving and facilitating adverse drug reaction (ADR) reporting.

Objective
In this research, we evaluated the potentiality of a new mobile app (vaxEffect@UniMiB) to perform longitudinal studies, while preserving the anonymity of the respondents. We applied the app to monitor the ADRs during the COVID-19 vaccination campaign in a sample of the Italian population.

Methods
We administered vaxEffect@UniMiB to a convenience sample of academic subjects vaccinated at the Milano-Bicocca University hub for COVID-19 during the Italian national vaccination campaign. vaxEffect@UniMiB was developed for both Android and iOS devices. The mobile app asks users to send their medical history and, upon every vaccine administration, their vaccination data and the ADRs that occurred within 7 days postvaccination, making it possible to follow the ADR dynamics for each respondent. The app sends data over the web to an application server. The server, along with receiving all user data, saves the data in a SQL database server and reminds patients to submit vaccine and ADR data by push notifications sent to the mobile app through Firebase Cloud Messaging (FCM). On initial startup of the app, a unique user identifier (UUID) was generated for each respondent, so its anonymity was completely ensured, while enabling longitudinal studies.

Results
A total of 3712 people were vaccinated during the first vaccination wave. A total of 2733 (73.6%) respondents between the ages of 19 and 80 years, coming from the University of Milano-Bicocca (UniMiB) and the Politecnico of Milan (PoliMi), participated in the survey. Overall, we collected information about vaccination and ADRs to the first vaccine dose for 2226 subjects (60.0% of the first dose vaccinated), to the second dose for 1610 subjects (43.4% of the second dose vaccinated), and, in a nonsponsored fashion, to the third dose for 169 individuals (4.6%).

Conclusions
vaxEffect@UniMiB was revealed to be the first attempt in performing longitudinal studies to monitor the same subject over time in terms of the reported ADRs after each vaccine administration, while guaranteeing complete anonymity of the subject. A series of aspects contributed to the positive involvement from people in using this app to report their ADRs to vaccination: ease of use, availability from multiple platforms, anonymity of all survey participants and protection of the submitted data, and the health care workers’ support.
Peran Dinas Perikanan Dalam Pemberdayaan Masyarakat Nelayan Dan Implikasinya Terhadap Ketahanan Ekonomi Keluarga Nelayan (Studi Pada Kampung Nelayan Di Kecamatan Bula, Kabupaten Seram Bagian Timur, Provinsi Maluku)
Authors: Rumarey Wattimena Zarita Kaulika , Rustadi Rustadi , Suadi Suadi 
Published: August 2022

ABSTRACT This study aimed to analyzed the role of Department of Fishery of Seram Bagian Timur Regency using the Siagian theory in 2003, through 5 role indicators namely the role of stabilizer, innovator, modernizr, pioneer and implementer as well as the implications of the role of the service on the economic resilience of fishermen's families which included: place of residence (home ownership) , income, education costs and health insurance in Bula Fisherman's Village SBT Regency.This research was a qualitative descriptive study, with data collection techniques using qualitative methods with samples of 6 informants from the officers in the Fisheries Services and 5 fishers informants representing 3 fish farmer groups. The data collection techniques used were (1) observation (2) interviews, and (3) documentation with data analysis techniques through qualitative description analysis which drew conclusions analytically through the stages of data reduction, data presentation and conclusion drawing.The results of the study indicated that Department of Fishery of SBT Regency had not carried out its main duties and functions optimally. The limitations of its implementation, both the role and implementation of policies, were still hampered by a number of factors, namely budget constraints, low quality of human resources, government policies and inadequate facilities and infrastructure. So, that the local governments had not been effective in managing and utilizing fishery resources. The implication of the role of Office of Fishery of SBT in empowering fishermen showed that it still had not had a positive influence on the economic condition of the fishermen's families, most of the fishing families had family economic resilience that was included in the less resilient category, namely there were still many family of fisherman who lived in poverty. In order to supporedt the success of the role of the Department of Fisheries, a number of supporting factors were needed that could encourage the regional economy through marine and fisheries-based regional development, namely fishery resources, human resources and government policies (budget).
Toxicological Effects of Lead Nitrate on Biochemical Parameters of Fresh Water Fish Oreochromis niloticus
Authors: Sasikumar S. , Prakash Sahaya Leon J. 
Published: August 2022

Freshwater systems are exposed to a variety of pollution sources, such as industrial waste, domestic sewage, agricultural disposal and mining processes. Most of the heavy metals entering into the food chain cause physiological damage for aquatic organisms. The toxicological effects of heavy metals are to non-target organisms like freshwater fishes. Lead is the most important heavy metal that causes bio accumulative toxicity in fish and other aquatic organisms. Lead nitrate is one of the heavy metals, that are found in the environment and causes many adverse effects. Oreochromis niloticus is an important species in commercial fisheries in the world. Human consumption of heavy- metal polluted water can have direct or indirect effects on human health. The present study analyzed the accumulation of heavy metals in water, fish Nile tilapia and also conducted a health risk assessment on humans. In the present study, the 96h LC50 values recorded for lead nitrate was 43ppm.The fish Oreochromis niloticus were treated for the sub lethal concentration of 1/10th,1/20/ and 1/30of lead nitrate (Pb (NO3)2) for the period of 30 days to get biochemical variations of different tissues in the Gill, Liver, Muscle and Kidney. The decreased level of Carbohydrate observed in Lead nitrate exposed fish at all the sub lethal concentrations (1/10, 1/20 and 1/30). The level of total protein and Lipid concentrations were decreased in Gill, Liver, Muscle and Kidney of lead nitrate treated fish Oreochromis niloticus. The depletion of protein, lipid, Carbohydrate content in Gill, Liver, Muscle and Kidney tissues of Oreochromis niloticus was due to the toxicant stress caused by Heavy metal Lead nitrate. A questionnaire-based dietary survey was conducted in 1000 healthy humans from the general population at various fish markets in various places of Krishnagiri district, Tamilnadu. Dietary data were collected in detail through face-to-face interview only on tilapia consumption. Intake (g) was computed. Statistical analyses were conducted using SPSS for Windows and all tests were considered significant at p< 0:05
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Cement Choice and the Fatigue Performance of Monolithic Zirconia Restorations
Authors: Guilardi LF , Pereira GKR , Giordani JC , Kleverlaan CJ , Valandro LF , Rippe MP 
Published: August 2022

SUMMARY
This study investigated the fatigue failure load of simplified monolithic yttria partially stabilized zirconia polycrystal restorations cemented to a dentin-like substrate using different luting systems. Disc-shaped ceramic (Zenostar T, 10 mm Ø × 0.7 mm thick) and dentin-like substrate (10 mm Ø × 2.8 mm thick) were produced and randomly allocated into eight groups, without or with thermocycling (TC=5–55°C/12,000×): “cement” (RelyX Luting 2 – glass ionomer cement [Ion], [Ion/TC]; RelyX U200 – self-adhesive resin cement [Self], [Self/TC]; Single Bond Universal+RelyX Ultimate – MDP-containing adhesive + resin cement [MDPAD + RC], [MDP-AD + RC/TC]; ED Primer II+Panavia F 2.0 – Primer + MDP-containing resin cement [PR + MDP-RC], [PR + MDP-RC/TC])). Each luting system was used as recommended by the manufacturer. Staircase methodology (20 Hz; 250,000 cycles) was applied for obtaining the fatigue failure loads. Fractographic characteristics were also assessed. At baseline, the Ion group presented the lowest fatigue load, although it was statistically similar to the Self group. The resin-based cement systems presented the highest fatigue performance, with the Ion group being only statistically equal to the Self group. Thermocycling influenced the groups differently. After aging, the MDP-AD + RC presented the highest mean, followed by the PR + MDP-RC and Self groups, while the Ion group had the lowest mean. Fractographic analysis depicted all failures as radial cracks starting at the zirconia intaglio surface. The luting system with MDP-containing adhesive applied prior to the resin cement presented the highest fatigue failure load after aging, presenting the best predictability of stable performance. Despite this, monolithic zirconia presents high load-bearing capability regardless of the luting agent.
Influence of the Flowable Resin Layer on Bond Strength Between Resin Cement and a Universal Adhesive Applied in the Immediate Dentin-sealing Technique
Authors: Batista JMN , Leite MM , Sabag MF , Lopes LG , Torres ÉM 
Published: August 2022

SUMMARY

Objectives
The present study evaluated the influence of a flowable resin layer on bond strength between resin cement and a universal adhesive applied using an immediate dentin sealing (IDS) technique.

Methods and Materials
Coronary portions of bovine teeth were randomly divided into six groups (n=15). In the IDS.U group, the exposed dentin was immediately sealed with the Single Bond Universal adhesive (3M ESPE) following the self-etching protocol. In the IDS.UF group, a layer of Filtek Z350 (3M ESPE) flow resin was applied over the universal adhesive. In the DDS (control) group, the dentin was kept “fresh” and delayed dentin sealing was performed. After 24 hours in distilled water at 37°C, dentin surfaces were treated with pumice, phosphoric acid, and the application of the universal adhesive in the IDS.U and IDS. UF groups. The DDS group was treated with pumice and the universal adhesive was applied. The samples received cylinders of resin cement Rely X Ultimate (3M ESPE) made with the aid of starch tubes of 0.96 mm in diameter and 2 mm in length. They were submitted to the microshear bond strength test (μSBS) at 0.5 mm/min, after 24 hours (T1) and 3 months (T2). The fracture areas were evaluated qualitatively using a DSM 300 microscope (KOZO) with 45× magnification and classified as: adhesive, cohesive in cement, cohesive in dentin, or mixed. Samples were analyzed by scanning electron microscopy (SEM). The data were compared statistically between groups using the Kruskal-Wallis test, and intra-groups using the Mann-Whitney test (α=0.05).

Results
There were no significant differences between groups for the bond strength values (p&gt;0.05). The IDS.UF group showed higher values at 3 months, when compared to the values of 24 hours (p&lt;0.001). All groups showed a predominance of adhesive fracture (86.7% to 100%). SEM showed dentinal tubules exposed in the IDS.U and DDS groups; in the IDS.UF group, the tubules were completely sealed.

Conclusions
The flow resin can be used on the adhesive when using the IDS technique because it increased the bond strength values after 3 months and promoted effective sealing of the dentinal tubules.
Characterization of Contemporary Conventional, Bulk-fill, and Self-adhesive Resin Composite Materials
Authors: David C , Cuevas-Suárez CE , de Cardoso GC , Isolan CP , de Moraes RR , da Rosa WLO , Münchow EA , da Silva AF 
Published: August 2022

SUMMARY

Objective
To evaluate the physical and biological properties of different types of flowable resin composites and their bonding ability to dentin, comparing the performance of self-adhesive and bulk-fill materials with a conventional control.

Methods and Materials
Four flowable resin composites were tested: two self-adhesive (Y-flow [SA_YF]; and Dyad Flow [SA_DF]); one bulk-fill (Filtek Bulk Fill Flow [BF]); and one conventional composite (Opallis Flow [OF]). The microshear bond strength (μSBS) to dentin (bovine samples) was investigated at 24 hours and 6 months of storage. The materials were also characterized by degree of conversion, cross-link density, water contact angle, color stability, and cell viability (ISO 10993-5/2009) analyses. Data were analyzed using Analysis of Variance and Tukey tests (α=0.05).

Results
The μSBS values were higher for control specimens at 24 hours, whereas the resin-dentin bonds were similarly distributed among the groups after aging. Adhesive failure was the most frequent pattern observed at both time intervals. SA_YF was the only material that increased the bond strength over time. Degree of conversion increased in the following order: SA_YF (28.6±1.4%) &lt; BF (49.7±0.8%) &lt; OF (60.0±2.0%) = SA_DF (63.6±2.3%). Cross-link density was similar among all materials. The self-adhesive composites were more hydrophilic than the other types, with BF showing the lowest water contact angle and the greatest color alteration. All resin composites had a biocompatible behavior.

Conclusion
Chemical composition appeared to be an influential factor affecting the physico-mechanical and biological behavior of the materials tested.
Retention of Manually or CAD/CAM-customized Fiberglass Posts Luted to Enlarged Root Canals with Different Resin Cements
Authors: Bellan MC , da Cunha PFJS , Colombino ACL , Bittencourt HR , Mota EG , Borges GA , Spohr AM 
Published: August 2022

SUMMARY
The aim of this laboratory study was to evaluate the pull-out force of a prefabricated fiberglass post (PP), relined fiberglass post (RP), or milled fiberglass post (MP) luted with Multilink N (MN), RelyX Unicem 2 (RXU2) or RelyX Ultimate (RU) to enlarged root canals. The thickness of the resin cements and the presence of voids in the resin cement film were observed. The root canals of 90 bovine incisors were enlarged, endodontically treated, and randomly divided into 9 groups (n=10) according to the post type and resin cement. The specimens were scanned using micro-CT to analyze the thickness of the resin cement and the presence of voids. The specimens were submitted to mechanical cyclic loading (500,000 cycles at 50 N load) and subjected to pull-out force testing. Two-way ANOVA and Tukey’s test analyzed the pull-out force and resin cement thickness data. Kruskal-Wallis and Bonferroni tests analyzed the void scores. The interaction between factors (post × resin cement) was significant (p=0.0001) for the pull-out force. Higher pull-out forces were obtained for RP and MP compared to PP. The post factor was significant (p=0.0001) for resin cement thickness, which was higher for PP (1054 μm), followed by MP (301 μm) and RP (194 μm). More void formation occurred for PP, being less for RP, differing significantly among the posts. Post customization (RP and MP) decreased resin cement thickness and void formation, favoring a higher pull-out force. Resin cements requiring an adhesive application (MN and RU) favored higher pull-out force than self-adhesive resin cement (RXU2).