bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness of the SMILE intervention compared with usual care for people with severe mental illness: A randomized clinical trial
Authors: El Alili Mohamed , van Meijel Berno , van Tulder Maurits W. , Adriaanse Marcel 
Published: January 2025

Objectives
Only studying effectiveness of lifestyle interventions for people with severe mental illness (SMI) is insufficient for policy making. As budgets for healthcare are limited, policy makers face the problem of allocating scarce healthcare resources. Cost-effectiveness studies are needed, but currently cost-effectiveness studies of lifestyle interventions for people with SMI delivered in ambulatory care are limited. The aim of this current study was to evaluate the cost-effectiveness of a lifestyle intervention for people with SMI living in the Dutch community in comparison with usual care.

Methods and findings
An economic evaluation was performed using a societal perspective alongside the Severe Mental Illness Lifestyle Evaluation (SMILE) pragmatic cluster randomized controlled trial. The SMILE lifestyle intervention is a one-year, group-based intervention delivered by trained mental healthcare workers. Costs, body weight change and quality of life were assessed at baseline, 6 and 12 months. Mixed models were used to estimate incremental costs and effects between the treatment group and the usual care group. Overall, the SMILE intervention resulted in lower total costs compared to the usual care group (-€719, 95% CI -7133; 3897). The effect difference between the intervention and usual care groups was -3.76 (95% CI -6.30; -1.23) kilograms for body weight and -0.037 (95% CI -0.083; 0.010) for QALYs.

Conclusions
Overall, the SMILE intervention resulted in lower total costs compared to the usual care group and was cost-effective for body weight change. However, the SMILE intervention does not seem cost-effective with regards to QALYs. More cost-effectiveness studies in other countries and other settings are needed to gain further insight into the cost-effectiveness of lifestyle interventions for people with SMI.
Age-related variations in physical activity, happiness, and psychological well-being: Evidence from Iran
Authors: VaezMousavi Mohammad , Carneiro Lara , Shams Amir , Abbasi Hamed , Dehkordi Parvaneh Shamsipour , Bayati Mahdi , Nobari Hadi 
Published: January 2025

Background
Physical activity (PA) is associated with higher levels of PWB and happiness. The high prevalence of physical inactivity among the Iranian population is concerning. Moreover, according to the Happiness Report 2024, Iran is ranked 100th out of 143 countries. Thus, this research aimed to study the PWB, happiness, and PA in Iranian age groups.

Methods
The study sampled 1,050 participants, equally divided into young, middle-aged, and elderly groups, using randomized cluster sampling from urban areas across five geographic regions in Iran. The study utilized four questionnaires: a Demographic Information Questionnaire, the International Physical Activity Questionnaire (IPAQ), Ryff’s Scales of PWB (18-item form), and the Oxford Happiness Questionnaire (OHQ). Descriptive statistics were used for summarizing data, and inferential analyses included Pearson’s correlation coefficient, one-way ANOVA, the Bonferroni test, and multivariate regression, all with a significance level set at P<0.05.

Results
Middle-aged individuals had the highest PA (1015.69±730.63 MET-minutes per week) and reported the highest happiness (111.97±24.08) and PWB (63.75±11.17) levels. The elderly had the lowest levels of PA (677.78±592.50 MET-minutes per week), happiness (107.63±24.01), and PWB (60.05±10.02). Statistical tests showed significant differences in PA, happiness, and PWB between the age groups (P<0.05), with no significant difference between young and elderly in PA (P>0.05). Physical activity positively correlated with happiness and PWB, especially in the elderly. Multivariate regression revealed that PA significantly predicts happiness (F = 30.993, t = 6.96, B = 0.211) and PWB (F = 86.85, t = 9.32, B = 0.004), explaining 4.4% and 8.0% of their variances, respectively.

Conclusions
The study concludes that increasing PA enhances happiness and PWB. Practical applications include promoting PA to improve mental health and PWB. Future research should investigate the effects of specific types of PA and explore longitudinal impacts on PWB to provide a deeper understanding of these relationships.
Using deep learning to shorten the acquisition time of brain MRI in acute ischemic stroke: Synthetic T2W images generated from b0 images
Authors: Peng Yun , Wu Chunmiao , Sun Ke , Li Zihao , Xiong Liangxia , Sun Xiaoyu , Wan Min , Gong Lianggeng 
Published: January 2025

Objective
This study aimed to assess the feasibility of the deep learning in generating T2 weighted (T2W) images from diffusion-weighted imaging b0 images.

Materials and methods
This retrospective study included 53 patients who underwent head magnetic resonance imaging between September 1 and September 4, 2023. Each b0 image was matched with a corresponding T2-weighted image. A total of 954 pairs of images were divided into a training set with 763 pairs and a test set with 191 pairs. The Hybrid-Fusion Network (Hi-Net) and pix2pix algorithms were employed to synthesize T2W (sT2W) images from b0 images. The quality of the sT2W images was evaluated using three quantitative indicators: Peak Signal-to-Noise Ratio (PSNR), Structural Similarity (SSIM), and Normalized Mean Squared Error (NMSE). Subsequently, two radiologists were required to determine the authenticity of (s)T2W images and further scored the visual quality of sT2W images in the test set using a five-point Likert scale. The overall quality score, anatomical sharpness, tissue contrast and homogeneity were used to reflect the quality of the images at the level of overall and focal parts.

Results
The indicators of pix2pix algorithm in test set were as follows: PSNR, 20.549±1.916; SSIM, 0.702±0.0864; NMSE, 0.239±0.150. The indicators of Hi-Net algorithm were as follows: PSNR, 20.646 ± 2.194; SSIM, 0.722 ± 0.0955; NMSE, 0.469 ± 0.124. Hi-Net performs better than pix2pix, so the sT2W images obtained by Hi-Net were used for radiologist assessment. The two readers accurately identified the nature of the images at rates of 69.90% and 71.20%, respectively. The synthetic images were falsely identified as real at rates of 57.6% and 57.1%, respectively. The overall quality score, sharpness, tissue contrast, and image homogeneity of the sT2Ws images ranged between 1.63 ± 0.79 and 4.45 ± 0.88. Specifically, the quality of the brain parenchyma, skull and scalp, and middle ear region was superior, while the quality of the orbit and paranasal sinus region was not good enough.

Conclusion
The Hi-Net is able to generate sT2WIs from low-resolution b0 images, with a better performance than pix2pix. It can therefore help identify incidental lesion through providing additional information, and demonstrates the potential to shorten the acquisition time of brain MRI during acute ischemic stroke imaging.
A retrospective comparative study of the clinical and radiological outcomes of intertrochanteric fractures treated with proximal femoral nail antirotation (PFN-A) and INTERTAN nail
Authors: Varmış Hasan Orkun , Gökmen Mehmet Yiğit , Tan İsmet 
Published: January 2025

Background
This study aimed to analyze the files of patients treated using PFN-A or INTERTAN intramedullary nails to reveal additional superiorities or disadvantageous factors for selecting the better intramedullary fixation method in patients presenting with intertrochanteric femur fractures.

Methods
In this retrospective study, the files of the patients who were operated on for intertrochanteric femur fractures using intramedullary fixation methods between September 2010 and June 2015 in the Orthopedics and Traumatology Clinic, Çukurova University Faculty of Medicine, were reviewed. The data including age, gender, chronic diseases, causes of fractures, fracture classification based on Arbeitsgemeinschaft für Osteosynthesefragen (AO), the nail type (long or short), the interval between trauma and surgery, duration of anesthesia and surgery, hospitalization duration, amount of blood transfusion, the Tip-Apex Distance (TAD) in postoperative radiographs, functional outcomes according to Harris Hip Score (HHS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), postoperative complications, need for revision, and mortality was noted.
The data of the follow-up visits included physical examination findings in addition to the radiological assessment findings obtained using X-ray imaging involving the evaluation of the union in terms of the presence of infection, loss of reduction, implant failure, avascular necrosis, additional signs related to poor union formation, and the position data of the lag screw placement point according to Cleveland and Bosworth Quadrants.

Results
The records showed that 194 files were available for analysis. The mean age of the patients included in the study was 70.9±16.4 years; 100 patients (51.5%) were male, and 94 (48.5%) were female. There were 76 patients (39%) in the PFN-A group and 118 patients (61%) in the INTERTAN group. Analysis of the mean Harris Hip Scores in both nail groups showed that only the mean scores at the 1st follow-up were statistically significantly different (P = 0.025).

Conclusion
In conclusion, comparing the two nail types in terms of complication rates and clinical data, neither nail has proven superior to the other. Moreover, the temporary difference in the first follow-up HHS scores should not be considered an indicator of the overall functional outcome because long-term follow-up HHS scores did not differ.
Unveiling endothelial cell border heterogeneity: VE-cadherin adherens junction stratification by deep convolutional neural networks
Authors: Postma Rudmer J. , Fischer Susan E. , Bijkerk Roel , van Zonneveld Anton Jan 
Published: January 2025

Background
Systemic diseases are often associated with endothelial cell (EC) dysfunction. A key function of ECs is to maintain the barrier between the blood and the interstitial space. The integrity of the endothelial cell barrier is maintained by VE-Cadherin homophilic interactions between adjacent cells. The morphology of these borders is highly dynamic and can be actively remodeled by numerous drivers in a (patho)physiologic context specific fashion.

Objectives
High-content screening of the impact of circulatory factors on the morphology of VE-Cadherin borders in endothelial monolayers in vitro will enable the assessment of the progression of systemic vascular disease. We therefore aimed to create an image analysis pipeline, capable of automatically analyzing images from large scale screenings, both capturing all VE-cadherin phenotypes present in a sample while preserving the higher-level 2D structure. Our pipeline is aimed at creating 1D tensor representations of the VE-cadherin adherence junction structure and negate the need for normalization.

Method
An image analysis pipeline, with at the center a convolution neural network was developed. The deep neural network was trained using examples of distinct VE-Cadherin morphologies from many experiments. The generalizability of the model was extensively tested in independent experiments, before further validation using ECs exposed ex vivo to plasma from patients with liver cirrhosis and proven vascular complications.

Results
Our workflow was able to detect and stratify many of the different VE-Cadherin morphologies present within the datasets and produced similar results within independent experiments, proving the generality of the model. Finally, by EC-cell border morphology profiling, our pipeline enabled the stratification of liver cirrhosis patients and associated patient-specific morphological cell border changes to responses elicited by known inflammatory factors.

Conclusion
We developed an image analysis pipeline, capable of intuitively and robustly stratifying all VE-Cadherin morphologies within a sample. Subsequent VE-Cadherin morphological profiles can be used to compare between stimuli, small molecule screenings, or assess disease progression.
The Umayyad Mosque of Damascus: Art, Faith and Empire in Early Islam, Alain George, Edited by Melanie Gibson (2020)
Authors: Williams Joseph C. 
Published: January 2025

Review of: The Umayyad Mosque of Damascus: Art, Faith and Empire in Early Islam, Alain George, Edited by Melanie Gibson (2020)
London: Gingko, 264 pp., 150 colour illus.,
ISBN: 9781909942455, $85 (hardback)
Research on the Coupled Coordination of the Digital Economy and Environmental Quality
Authors: Luan Xiaomei , Zhang Zhuang , Chen Chibo , Chang Jing , Huang Juan 
Published: January 2025

Abstract
Few studies provide direct evidence that there is a coupling coordination relationship (CCR) between the digital economy and environmental quality. This study tries to fill this gap. Using panel data from 31 provinces in China from 2011 to 2020, we conclude that there is a symbiotic CCR with an increasing degree over time between China’s digital economy and environmental quality and it is more visible in eastern, central than other areas. Further study shows that the regional heterogeneity of coordination is mainly due to inter-group rather than intra-group. The environmental regulations (ERs) play a crucial role in shaping future levels of coupled coordination and the conclusions are robust. Policymakers should simultaneously promote the development of the digital economy, improve the quality of the ecological environment, and pay attention to the inclination of ERs to the western and north-east regions. This analytical framework reveals the complex interaction between the digital economy and environmental quality, while the coupled coordination evaluation system developed here can provide valuable experience for developing countries to open new paths towards high-quality development.
Revival of the Escherichia coli heat shock response after two decades with a small Hsp in a critical but distinct act
Authors: Miwa Tsukumi , Taguchi Hideki 
Published: January 2025

Abstract
The heat stress response is an essential defense mechanism in all organisms. Heat shock proteins (Hsps) are produced in response to thermal stress, with their expression levels regulated by heat shock transcription factors. In Escherichia coli, the key transcription factor σ32 positively regulates Hsp expression. Studies from over two decades ago revealed that σ32 abundance is negatively controlled under normal conditions, mainly through degradation mechanisms involving DnaK, GroEL, and FtsH. Beyond this established mechanism, recent findings indicate that a small heat shock protein IbpA also plays a role in the translational regulation of σ32, adding a new layer to the established model. This review highlights the role of a new actor, IbpA, which strongly suppresses σ32 expression under non-stress conditions and markedly increases it during heat shock.
The crystal structure of trans–L/D-[bis-(2-methyl-8-hydroxyquinoline-κ
2
N,O) bis-(1,3,5-triaza-7-phosphaadamantane-κ
2
P)cobalt(III)] tetrafluoroborate
Authors: Alexander Orbett T. , Roodt Andreas 
Published: January 2025

Abstract
C32H40BCoF4N8O2P2, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 10.682(4) Å, b = 12.900(5) Å, c = 13.453(4) Å, α = 76.214(9)∘, β = 70.490(9)∘, γ = 70.449(10)∘, V = 1629.80(10) Å3, Z = 2, R
gt(F) = 0.0799, wRref(F
2) = 0.1820, T = 100 K.
Relationship between body mass index and quality of life, use of dietary and physical activity self-management strategies, and mental health in individuals with polycystic ovary syndrome
Authors: Masters Melissa , Grevstad Nels 
Published: January 2025

Abstract
Polycystic ovary syndrome (PCOS) can negatively affect health and well-being. This study aimed to assess quality of life, use of self-management strategies, stress, anxiety, and depression in people with PCOS, and the effect of body mass index (BMI) on these factors. An online survey was distributed on PCOS social media sites and email listservs. Categorical data were analyzed as counts and percentages. Relationships between BMI and scores for PCOS quality of life (PCOSQ), use of diet and physical activity self-management strategies, perceived stress scale, and hospital anxiety and depression scale were analyzed using simple linear regression analyses. Significance was set at p < 0.05. The median BMI of participants (n = 101) was 33.12 kg/m2. PCOSQ scores were similar across BMI groups for many domains. Linear regression analyses revealed that BMI predicted variation in weight and hirsutism scores. Self-management scores were low for all BMI groups. Linear regression analyses revealed no significant relationships between BMI and scores for self-management strategy categories. Most participants had moderate stress (n = 55, 59.8%), abnormal anxiety (n = 50, 56.2%), and normal depression (n = 48, 53.9%) levels. Linear regression analyses revealed no significant relationships between BMI and these scores. Individuals of all body sizes with PCOS may experience quality of life disruptions and mental health concerns and may utilize dietary and physical activity self-management strategies at a low level. In PCOS, quality of life and mental health concerns should be assessed, in addition to metabolic impacts, and an individualized approach to increasing the use of self-management strategies should be implemented.
Chemical Diversity of UK Grown Tea Explored Using Metabolomics and Machine Learning
Authors: Lloyd Amanda J. , Warren-Walker Alina , Finch Jasen , Harper Jo , Bennet Kathryn , Watson Alison , Lyons Laura , Martinez Martin Pilar , Wilson Thomas , Beckmann Manfred , Draper John 
Published: January 2025

Background/Objectives: Dartmoor Estate Tea plantation in Devon, UK, is renowned for its unique microclimate and varied soil conditions, which contribute to the distinctive flavours and chemical profiles of tea. The chemical diversity of fresh leaf samples from different were assessed via samples collected from various garden locations within the plantation. Methods: Fresh leaf, which differed by location, cultivar, time of day, and variety, were analysed using Flow Infusion Electrospray Ionisation Mass Spectrometry (FIE-MS). Results: Random forest classification revealed no significant differences between Georgian N2 cultivar garden locations. However, a significant degree of variability was observed within four tri-clonal variants (Tocklai Variety) with TV9 exhibiting greater similarity to the Georgian N2 cultivar compared to TV8 and TV11, while TV11 was found to be most like TV1. The intraclass variability in leaf composition was similar between the varieties. We explored the metabolic changes over the day in one variant (Camellia assamica Masters), yielding a model with a significant R2 value of 0.617 (p &amp;lt; 0.01, 3000 permutations). Starch and sucrose metabolism was found to be significant where the abundance of these chemical features increased throughout the day and then began to decrease at night.Conclusion: This research highlights the complex interplay of cultivars, geographical location, and temporal factors on the chemical composition of tea. It provides insightful data on the metabolic pathways influencing tea cultivation and production and underscores the importance of these variables in determining the final chemical profile and organoleptic characteristics of tea products.
The Analysis of Creative Content Virality in Jawa Pos-Radar Lawu Digital Media in the Era of Technology, Information, and Communication
Authors: Nur Wahyudin Sapta Arif , Sutejo Sutejo , Setiawan Agus 
Published: January 2025

Jawa Pos-Radar Lawu is part of the Jawa Pos Group which is oriented towards presenting important, interesting, and up-to-date information from various regions around Mount Lawu. Despite being less than a year old, this media outlet is dedicated to producing creative content through digital platforms. This is reflected in the diverse topics chosen periodically, which are based on their potential to be viral. This study aims to examine the virality of creative content on Jawa Pos-Radar Lawu’s digital media as a strategic approach to public communication in the context of the information and communication technology revolution. The researcher formulated two main research questions: (1) What factors contribute to the virality of content on Jawa Pos-Radar Lawu’s digital media? This study employs a qualitative approach, with the researcher serving as the primary instrument for data collection. The research involves gathering data from the following sources: (1) content documents with the highest visitor numbers, (2) visitor statistics from March, April, and May, (3) recorded interviews with key informants, and (4) direct observation of Jawa Pos-Radar Lawu’s digital media. The data analysis process includes three stages: data reduction, data presentation, and drawing conclusions. The findings indicate that the virality factors exhibited by Jawa Pos-Radar Lawu align with Berger's six theories of contagion: social currency, trigger, emotion, public, practical value, and story. The most dominant principles used are trigger, emotion and story.
Systematic review of clinical practice guidelines for the diagnosis and management of open angle glaucoma
Authors: Galvez-Olortegui Jose , Jarroudi Rachid Bouchikh-El , Silva-Ocas Isabel , Bernales-Urbina Susan , Mollo-Bautista Rosmery , Burgueño-Montañes Carmen , Galvez-Olortegui Tomas 
Published: January 2025

Abstract

Background/Objectives: To assess the methodological quality of Clinical Practice Guidelines(CPG) for the diagnosis and management of open angle glaucoma(OAG). Methods: A systematic review of CPGs for the diagnosis and management of OAG, published between January-2017 and November-2024, was carried out with a search in databases, meta-search engines, CPG development institutions, ophthalmology associations and CPG repositories(PROSPERO:CRD42024510656). 5 authors evaluated them independently, using the Appraisal of Guidelines for Research and Evaluation (AGREE-II) instrument. An individual assessment by domain (AGREE-II), an overall assessment of the guide, and its use with or without modifications was performed. Additionally, a meta-synthesis of the recommendations for the most relevant outcomes was carried out. Results: The lowest mean scores were in applicability and rigour of development(mean 43.2% and 46.1% respectively). The highest score(mean 73.9%) was for domain 4-‘Clarity of presentation’. NICE(92.1%), IETSI(77.5%) and SNSG(75.8%) presented the best score in domain 3-‘Rigour of development’. Only NICE, EGS-5-TGG, SNS, and MaHTAS are recommended, the last two with modifications when evaluating the overall quality of the analyzed CPGs. Most of the CPGs used GRADE approach for making recommendations. In the meta-synthesis, the CPGs show similar recommendations, however, we found variability in indications for selective laser trabeculoplasty(SLT) and minimally invasive glaucoma surgery(MIGS). Conclusions: NICE, IETSI and SNSG CPGs for the diagnosis and management of OAG have a high methodological quality, appraised with AGREE-II. NICE, EGS-5-TGG, IETSI and SNSG have high scores in applicability.