bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multi-site survey of providers on the management of heart failure with dilated cardiomyopathy in children
Authors: Law Yuk M. , Jacobs-Files Elizabeth , Auerbach Scott , Lal Ashwin K. , Richmond Marc , Schumacher Kurt , Singh Rakesh , Desai Arti 
Published: August 2022

AbstractWe conducted a scientific survey of paediatric practitioners who manage heart failure with dilated cardiomyopathy in children. The survey covered management from diagnosis to treatment to monitoring, totalling 63 questions. There were 54 respondents from 40 institutions and 3 countries. There were diverse selections of management options by the respondents in general, but also unanimity in some management options. Variation in practice is likely due to the relative paucity of scientific data in this field and lack of strong evidence-based recommendations from guidelines, which presents an opportunity for future research and quality improvement efforts as the evidence base continues to grow.
The foreign language effect on motivational quotes
Authors: Braida Barbara , Rodríguez-Ferreiro Javier , Hernández Mireia 
Published: August 2022

AbstractAccording to the “reduced emotionality hypothesis”, we are less emotionally driven when reasoning in a foreign language (FL) than in a native language (NL). We examined whether this foreign language effect (FLe) extends to the way we perceive motivational quotes (i.e., encouraging slogans conveying a profound and inspirational message): we expected FL participants to rate motivational quotes as less profound than NL participants. Strikingly, we observed the opposite: FL participants found motivational quotes more profound than NL participants, even after controlling for potential confounders (e.g., IQ, reasoning style). Both FL and NL participants gave similarly low profundity ratings to pseudo-profound bullshit sentences (i.e., meaningless sentences sounding profound), indicating that the message must be meaningful for the FLe to arise. We propose that, like space or time, language could promote psychological distance. This favours a focus on the background of a message to indicate profoundness.
Do party politics still matter? Examining the effect of parties, governments and government changes on the local tax rate in Sweden
Authors: Högström John , Lidén Gustav 
Published: August 2022

AbstractAccording to partisan theory, variations in policy choices and outputs originate from the party composition of the government studied. In this study, we take a novel approach to address such assumptions by linking changes in municipal taxes with local government changes. We also add a baseline scenario in which we examine whether the composition of the local government affects tax levels. Drawing on a dataset that contains official Swedish statistics from 1994 to 2018, we find convincing support for the partisan effect. Tax levels are higher under left-wing rule, and more specifically, tax cuts particularly occur when left-wing governments are replaced by right-wing ones. These results do not vanish when controls are accounted for, while it can be particularly noticed that the condition of the municipal economy influences partisan ambitions. These findings thereby contradict prior theoretical assumptions that the local arena is free from ideological battles.
Exclusive humanitarianism: Policy recommendations for genuine inclusion of persons with disabilities in humanitarian action
Authors: Young Kirsten 
Published: August 2022

AbstractThe challenge faced by Somalia's newly established National Disability Agency (NDA), along with other emerging actors in the disability arena, is how to address the perception that disability is primarily a humanitarian issue in a country that not only is in conflict but also faces cyclical humanitarian crises. A further challenge for the NDA is how to ensure that the humanitarian architecture put in place facilitates non-discrimination, as well as the inclusion of and participation by persons with disabilities. While a typical humanitarian architecture can inadvertently reinforce an already stigmatizing charity or welfare approach towards persons with disabilities, Somalia's experience demonstrates that humanitarian actors can do a lot with leadership, a willingness to leave agency branding behind, and an active committed partner such as the NDA. Nevertheless, genuine inclusion in Somalia's overall State-building project needs also to be the remit of development, reconciliation and similar actors, with access to and participation of persons with disabilities guaranteed in their range of processes and frameworks.
Changes in Arctic Halocline Waters Along the East Siberian Slope and in the Makarov Basin From 2007 to 2020
Authors: Bertosio Cécilia , Provost Christine , Athanase Marylou , Sennéchael Nathalie , Garric Gilles , Lellouche Jean‐Michel , Kim Joo‐Hong , Cho Kyoung‐Ho , Park Taewook 
Published: August 2022

AbstractThe evolution of halocline waters in the Makarov Basin and along the East Siberian continental slope is examined by combining drifting platform observations, shipborne hydrographic data, and simulations from a global operational physical model from 2007 to 2020. From 2012 onwards, relatively shallow and cold Atlantic‐derived lower halocline waters, previously restricted to the Lomonosov Ridge area, progressed eastward along the East Siberian continental slope. Their eastward extent abruptly shifted from 155°E to 170°E in early 2012, stabilized at 170°E until the end of 2015, then gradually advanced to reach the western Chukchi Sea in 2017. Such eastward progression led to a strengthening of the associated boundary current and to the shedding of mesoscale eddies of cold Atlantic‐derived waters into the lower halocline of the Makarov Basin in September 2015 and near the East Siberian continental slope in November 2017. Additionally, active mixing between upwelled Atlantic Water and shelf water formed dense warm water supplying the Makarov Basin lower halocline. The increasing contribution from Atlantic‐derived waters into the lower halocline along the East Siberian continental slope and in the Makarov Basin led to a weakening of the halocline, which is characteristic of a new Arctic Ocean regime that started in the early 2000s in the Eurasian Basin. Our results suggest that this new Arctic regime may now extend toward the Amerasian Basin.
Modulating and Resetting Impacts of Different Volcanic Eruptions on North Atlantic SST Variations
Authors: Chen Kefan , Ning Liang , Liu Zhengyu , Liu Jian , Yan Mi , Sun Weiyi , Li Longhui , Shi Zhengguo 
Published: August 2022

AbstractThis study investigates the impact of volcanic eruption on the North Atlantic (NA) sea surface temperature (SST) during the last millennium based on both model simulations and reconstructions. Our focus is on the two types of relations between the states of SST and associated climate variables before and after the eruption: modulating and resetting. Here, modulating means that the posterior conditions depend on the initial SST and the volcano‐induced cooling is linearly superimposed on the initial SST phases, while resetting means that the posterior conditions are independent from the initial condition. Our analysis demonstrates that equatorial and northern volcanic eruptions larger than 30 Tg could reset NA SST, and there is a limitation of SST decrease after eruption, indicating the largest SST decrease does not exceed a certain value. While equatorial volcanic eruptions larger than 100 Tg and northern volcanic eruptions larger than 30 Tg can reset subsurface temperature changes. In contrast, even the largest volcanic eruption during the last millennium cannot reset the Atlantic Meridional Overturning Circulation.
Constraining Magma Reservoir Conditions by Integrating Thermodynamic Petrological Models and Bulk Resistivity From Magnetotellurics
Authors: Cordell Darcy , Naif Samer , Troch Juliana , Huber Christian 
Published: August 2022

AbstractMagnetotelluric (MT) data image the bulk resistivity of the subsurface which can be used to infer magma reservoir conditions beneath volcanoes. The bulk resistivity of magma depends primarily on the melt volume fraction, temperature, and water content. These variables are coupled thermodynamically, yet mixing relations for bulk resistivity implicitly treat them as independent. Here, we use a parameterization of the rhyolite‐MELTS thermodynamic model to constrain relationships between melt fraction, temperature, dissolved water content and bulk resistivity for rhyolitic magmas. This method results in MT interpretations which are (a) thermodynamically consistent at near‐equilibrium conditions, (b) independent of temperature and water content estimates derived from erupted products, and (c) able to consider saturated melts containing a volatile (i.e., aqueous fluid) phase. The utility of the method is demonstrated with three case studies of silicic systems: Mono Basin, Newberry volcano and the Laguna del Maule Volcanic Field (LdMVF). The moderately conductive feature at Mono Basin can be explained by under‐saturated partial melt (6–15 vol%) at <775°C, indicating relatively stable magma storage conditions since the last eruption. However, a relatively resistive feature at Newberry Volcano requires lower temperatures (<750°C) than previous estimates, suggesting that the system has cooled since the last eruption. A conductive feature at the LdMVF cannot be explained by saturated or under‐saturated rhyolitic melt and requires additional conductive phases. These results demonstrate the potential of this new method to reduce uncertainty in MT interpretations and highlight the need for additional coupling strategies between petrology, geophysics, and thermo‐mechanical models to better understand magmatic systems.
Neglected Spatiotemporal Variations of Model Biases in Ensemble‐Based Climate Projections
Authors: Song Tangnyu , Huang Guohe , Wang Xiuquan 
Published: August 2022

AbstractThe Bayesian model averaging (BMA) method has been widely used for generating probabilistic climate projections. However, the averaging weights used in BMA can only reflect the spatially‐ and temporally‐averaged performance of each ensemble member, without the ability to address the spatiotemporal variations of model biases. This can lead to inevitable exaggeration or understatement of the contributions of individual members to the ensemble mean, thus reducing the robustness of the resulting probabilistic projections. Here we propose a new method to help address the neglected spatiotemporal variations of model biases. Through the proposed method, the BMA weights are used as prior distributions to drive the Bayesian discriminant analysis in order to generate refined weights for individual ensemble models according to their spatially‐ and temporally‐clustered performance. Through applying the proposed method to Canada, we demonstrate its effectiveness in generating robust probabilistic climate projections (e.g., the average R2 increases from 0.82 to 0.89).
Linking Distributed and Integrated Fiber‐Optic Sensing
Authors: Bowden Daniel C. , Fichtner Andreas , Nikas Thomas , Bogris Adonis , Simos Christos , Smolinski Krystyna , Koroni Maria , Lentas Konstantinos , Simos Iraklis , Melis Nikolaos S. 
Published: August 2022

AbstractDistributed Acoustic Sensing (DAS) has become a popular method of observing seismic wavefields: backscattered pulses of light reveal strains or strain rates at any location along a fiber‐optic cable. In contrast, a few newer systems transmit light through a cable and collect integrated phase delays over the entire cable, such as the Microwave Frequency Fiber Interferometer (MFFI). These integrated systems can be deployed over significantly longer distances, may be used in conjunction with live telecommunications, and can be significantly cheaper. However, they provide only a single time series representing strain over the entire length of the fiber. This work discusses theoretically how a distributed and integrated system can be quantitatively compared, and we note that the sensitivity depends strongly on points of curvature. Importantly, this work presents the first results of a quantitative, head‐to‐head comparison of a DAS and the integrated MFFI system using pre‐existing telecommunications fibers in Athens, Greece.
Projected Changes of Surface Winds Over the Antarctic Continental Margin
Authors: Neme Julia , England Matthew H. , McC. Hogg Andrew 
Published: August 2022

AbstractSurface winds around the Antarctic continent control coupled ocean‐ice processes that influence the climate system, including bottom water production, heat transport onto the continental shelf and sea ice coverage. However, few studies have examined projected changes in these winds, even though it would aid in the interpretation and understanding of the ocean's response to climate change. Using Coupled Model Intercomparison Project Phase 6 and reanalysis data, we show a significant reduction in the near‐Antarctic surface winds throughout the historical period that continues until the end of the twenty‐first century, amounting to 23% and 7% for the easterly and southerly wind components respectively under the high emission scenario. The most intense weakening happens during the summer season. We find that the weakening is coherent with the trend toward a positive Southern Annular Mode and a reduction of the pole‐to‐coast meridional pressure gradient, which we term Antarctic Annular Index.
Increasing Trends in Oceanic Surface Poleward Eddy Heat Flux Observed Over the Past Three Decades
Authors: Guo Yiming , Bachman Scott , Bryan Frank , Bishop Stuart 
Published: August 2022

AbstractMesoscale processes make the largest contribution to ocean variability and are significant agents in ocean heat transport. In this investigation, we provide evidence based on satellite observations for an increasing trend in surface transient eddy heat flux (EHF) over the period 1993–2020. The enhanced EHF is particularly prominent in western boundary currents and their extensions at mid‐latitudes, with increases of 20%–40% per decade. Additionally, we decompose the EHF trend into contributions from velocity variance, temperature variance and a coherence parameter using a Cauchy–Schwarz inequality. We find that each contributes to the spatial pattern of the trend in EHF, with the contribution from enhanced temperature variance dominating the global zonal mean EHF trend over the past few decades.
Do we get better outcomes from early treatment of Class III discrepancies?
Authors: DiBiase Andrew T. , Seehra Jadbinder , Papageorgiou Spyridon N. , Cobourne Martyn T. 
Published: August 2022

AbstractEarly orthodontic treatment in the mixed dentition aims to simplify definitive treatment in the permanent dentition. In Class III cases, this can be an effective strategy for the management of a local anterior crossbite, using either a removable or simple fixed appliance. For more significant Class III malocclusions, the decision to intervene early is a more difficult one. Traditionally, orthodontists in the UK have been reluctant to embark on early treatment in the presence of a skeletal Class III relationship but there is now some evidence that in selected cases, the use of protraction headgear can be a successful method of avoiding the need for later surgery. Although growth prediction in Class III cases is notoriously difficult, in the presence of maxillary retrognathia, the general dental practitioner should consider early referral of Class III cases to a specialist orthodontist.
Acidosis induces RIPK1-dependent death of glioblastoma stem cells via acid-sensing ion channel 1a
Authors: Clusmann Jan , Franco Klaus-Daniel Cortés , Suárez David Alejandro Corredor , Katona Istvan , Minguez Maria Girbes , Boersch Nina , Pissas Karolos-Philippos , Vanek Jakob , Tian Yuemin , Gründer Stefan 
Published: August 2022

AbstractEliciting regulated cell death, like necroptosis, is a potential cancer treatment. However, pathways eliciting necroptosis are poorly understood. It has been reported that prolonged activation of acid-sensing ion channel 1a (ASIC1a) induces necroptosis in mouse neurons. Glioblastoma stem cells (GSCs) also express functional ASIC1a, but whether prolonged activation of ASIC1a induces necroptosis in GSCs is unknown. Here we used a tumorsphere formation assay to show that slight acidosis (pH 6.6) induces necrotic cell death in a manner that was sensitive to the necroptosis inhibitor Nec-1 and to the ASIC1a antagonist PcTx1. In addition, genetic knockout of ASIC1a rendered GSCs resistant to acid-induced reduction in tumorsphere formation, while the ASIC1 agonist MitTx1 reduced tumorsphere formation also at neutral pH. Finally, a 20 amino acid fragment of the ASIC1 C-terminus, thought to interact with the necroptosis kinase RIPK1, was sufficient to reduce the formation of tumorspheres. Meanwhile, the genetic knockout of MLKL, the executive protein in the necroptosis cascade, did not prevent a reduction in tumor sphere formation, suggesting that ASIC1a induced an alternative cell death pathway. These findings demonstrate that ASIC1a is a death receptor on GSCs that induces cell death during prolonged acidosis. We propose that this pathway shapes the evolution of a tumor in its acidic microenvironment and that pharmacological activation of ASIC1a might be a potential new strategy in tumor therapy.
Chromatin-Associated Molecular Patterns (CAMPs) in sepsis
Authors: Nofi Colleen P. , Wang Ping , Aziz Monowar 
Published: August 2022

AbstractSeveral molecular patterns have been identified that recognize pattern recognition receptors. Pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) are commonly used terminologies to classify molecules originating from pathogen and endogenous molecules, respectively, to heighten the immune response in sepsis. Herein, we focus on a subgroup of endogenous molecules that may be detected as foreign and similarly trigger immune signaling pathways. These chromatin-associated molecules, i.e., chromatin containing nuclear DNA and histones, extracellular RNA, mitochondrial DNA, telomeric repeat-containing RNA, DNA- or RNA-binding proteins, and extracellular traps, may be newly classified as chromatin-associated molecular patterns (CAMPs). Herein, we review the release of CAMPs from cells, their mechanism of action and downstream immune signaling pathways, and targeted therapeutic approaches to mitigate inflammation and tissue injury in inflammation and sepsis.
Deterministic magnetic moment rotation in antiferromagnetic material by piezoelectric strain modulation
Authors: Liu Mengli , Ma Chengxin , Du Wei , Su Hua , Zhang Huaiwu , Liu Bo , Meng Hao , Tang Xiaoli 
Published: August 2022

AbstractAntiferromagnetic (AFM) spintronic devices play a vital role in the development of novel spintronic devices due to their attractive features. Herein, the interfacial state manipulation of the AFM IrMn material is investigated by combining a ferroelectric single crystal Pb(Mg1/3Nb2/3)0.7Ti0.3O3 (PMN-PT) with an electric field (E-field)-controlled magnetic moment arrangement of the IrMn film. A PMN-PT/Cu/IrMn/NiFe heterostructure is chosen to confirm the deterministic manipulation of AFM interfacial states and its angle of magnetic moment rotation. The appropriate thickness of the Cu layer is selected to disrupt the strain-mediated magnetoelectric coupling between the NiFe layer and PMN-PT substrate. The NiFe film reference layer can reflect the variation in AFM interfacial states via the exchange bias. When the E-field is applied, an in-plane piezoelectric strain is produced. If IrMn responds to the strain, its magnetic moment rotates from [001] to [1−10] depending on the crystal orientation of PMN-PT. Based on the experimental results and theoretical analyses, a rotation in the magnetic moment of the IrMn layer by ~20° is confirmed. This work provides convincing evidence for the manipulation of E-field-controlled AFM interfacial states and describes a reliable method for achieving the rotation angle of AFM moments, which can help to accelerate the development of AFM spintronic devices.
Intelligent control of nanoparticle synthesis on microfluidic chips with machine learning
Authors: Chen Xueye , Lv Honglin 
Published: August 2022

AbstractNanoparticles play irreplaceable roles in optoelectronic sensing, medical therapy, material science, and chemistry due to their unique properties. There are many synthetic pathways used for the preparation of nanoparticles, and different synthetic pathways can produce nanoparticles with different properties. Therefore, it is crucial to control the properties of nanoparticles precisely to impart the desired functions. In general, the properties of nanoparticles are influenced by their sizes and morphologies. Current technology for the preparation of nanoparticles on microfluidic chips requires repeated experimental debugging and significant resources to synthesize nanoparticles with precisely the desired properties. Machine learning-assisted synthesis of nanoparticles is a sensible choice for addressing this challenge. In this paper, we review many recent studies on syntheses of nanoparticles assisted by machine learning. Moreover, we describe the working steps of machine learning, the main algorithms, and the main ways to obtain datasets. Finally, we discuss the current problems of this research and provide an outlook.
Mycobacterial resistance to zinc poisoning requires assembly of P-ATPase-containing membrane metal efflux platforms
Authors: Boudehen Yves-Marie , Faucher Marion , Maréchal Xavier , Miras Roger , Rech Jérôme , Rombouts Yoann , Sénèque Olivier , Wallat Maximilian , Demange Pascal , Bouet Jean-Yves , Saurel Olivier , Catty Patrice , Gutierrez Claude , Neyrolles Olivier 
Published: August 2022

AbstractThe human pathogen Mycobacterium tuberculosis requires a P1B-ATPase metal exporter, CtpC (Rv3270), for resistance to zinc poisoning. Here, we show that zinc resistance also depends on a chaperone-like protein, PacL1 (Rv3269). PacL1 contains a transmembrane domain, a cytoplasmic region with glutamine/alanine repeats and a C-terminal metal-binding motif (MBM). PacL1 binds Zn2+, but the MBM is required only at high zinc concentrations. PacL1 co-localizes with CtpC in dynamic foci in the mycobacterial plasma membrane, and the two proteins form high molecular weight complexes. Foci formation does not require flotillin nor the PacL1 MBM. However, deletion of the PacL1 Glu/Ala repeats leads to loss of CtpC and sensitivity to zinc. Genes pacL1 and ctpC appear to be in the same operon, and homologous gene pairs are found in the genomes of other bacteria. Furthermore, PacL1 colocalizes and functions redundantly with other PacL orthologs in M. tuberculosis. Overall, our results indicate that PacL proteins may act as scaffolds that assemble P-ATPase-containing metal efflux platforms mediating bacterial resistance to metal poisoning.