bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of Health and Disease Assessment among Selected Marginalized Barangays in Malaybalay City
Authors: Barroso Carina Joane V. , Alava Corazon G 
Published: October 2022

This study was conducted to determine the quality of health among marginalized barangays in Malaybalay City. The study aimed to identify and assess the morbidity rates of the following diseases: waterborne, vector borne, communicable and non-communicable; and assessed the health conditions of individuals in marginalized communities and correlate the incidence/cases of waterborne, vector borne, communicable and non-communicable diseases with the barangays’ poverty index. Regression analysis was used to correlate poverty and health. Findings revealed that poverty status has moderate positive relationship with the incidence of dengue, tuberculosis and diarrhea, while there is only slight positive relationship between poverty status and the occurrence of diabetes among the marginalized barangays.Keywords; waterborne, vector borne, communicable and non-communicable diseases, poverty and health
Poverty Alleviation and the Access and Utilization of Information and Communication Technology (ICT) among Select Sectors in Bukidnon
Authors: Barretto Remedios G , Alava Corazon G , Simbulan Sol G , Cunanan Adela A , Ramos Mercedes Gloria , Espina Marilou , Inovejas Christian J , Un Luz B 
Published: October 2022

This study investigated the role of ICT on the social, economic and political aspects of selected upland farmers, lowland farmers, and senior citizens. Specifically, it determined how respondents in the said sectors access and utilize information and communication using ICT; and related the influence of ICT in an effort to alleviate their social, economic and political conditions.The findings of the study revealed that both the old and new forms of ICT resources were accessed and utilized by the three sectors. Most respondents from the upland and lowland farmers, and senior citizens that have improved income in the past ten years used/accessed ICT. The presence of ICT and the consequent use of said respondents explained the increase in the income in 89.6 percent of the cases. The findings showed that the use of ICT resources contributes in alleviating poverty among the respondents.Keywords: Information and Communication Technology (ICT), poverty alleviation
A novel risk factor of contrast associated acute kidney injury in patients after enhanced computed tomography: a retrospective study
Authors: Li You-Qi , Shi Yongjun , Deng Wen-feng , Xiao Shaobin , Hu Wenwen , Huang Chengwen , Tang Xun , Zhang Jun 
Published: October 2022

Background
Contrast associated acute kidney injury (CA-AKI) is a major cause of acute renal failure and the incidence of CA-AKI is still high in recent years. Risk stratification is traditionally based on glomerular filtration rate(GFR). Hence, the aim of this study was to explore the novel risk factors for CA-AKI after enhanced computed tomography (CT).

Methods
A retrospective cohort study was conducted in 632 in-hospital patients undergoing enhanced CT. The patients were divided into CA-AKI and no-CA-AKI groups. For comparative analyses, we applied one-to-four cohorts of those two groups using propensity score-matching methods addressing the imbalances of age, gender, weight, and smoking. The baseline clinical and biochemical data were compared. Logistic regression analysis was employed to investigate the CA-AKI risk factors. The receiver operating characteristic (ROC) curve was adopted to test the value of RDW in predicting CA-AKI after enhanced CT.

Results
25 (3.96%) patients suffered from CA-AKI. Those subjects who developed CA-AKI had advanced age, severer renal functional injury, lower albumin, higher baseline RDW, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) than those without CA-AKI. It also exhibited more severe anemia including decreased hemoglobin and red blood cell count (all p < 0.05). The baseline RDW, albumin and PLR between the two groups were statistically significant different after PSM. Binary logistic regression analysis showed that baseline RDW, albumin and eGFR were correlated with CA-AKI after contrast-enhanced CT examination. The RDW exhibited moderated discrimination ability for predicting CA-AKI beyond eGFR, with an AUC of 0.803 (95% CI [0.702–0.90]) vs 0.765 (95% CI [0.70–0.83]).

Conclusion
Increased baseline RDW and decreased eGFR are risk factors for CA-AKI after enhanced CT. RDW exhibited good predictive value and can be used as an early warning marker for patients suffering from CA-AKI after enhanced CT.
Predictors of Patient and Physician Assessments of Gout Control
Authors: Dalbeth Nicola , Frampton Christopher , Fung Maple , Baumgartner Scott , Choi Hyon K. 
Published: October 2022

ObjectiveTo understand the clinical variables that contribute to the patient and physician assessments of gout control and which variables predict discordant assessments.MethodsPatients (n = 223) with gout taking allopurinol ≥300 mg daily attended a standardized gout assessment visit. Participants and physicians completed questionnaires rating their assessment of current gout control using a numerical rating scale (0 = not at all controlled, 10 = fully controlled). Discordance between patients’ and physicians’ scores was defined as an absolute difference of >2 units.ResultsThe mean ± SD patient gout control score was 8.09 ± 2.24, and the physician gout control score was 7.38 ± 2.63 (P < 0.001 for comparison). Absence of gout flares in the last 12 months and in the last 3 months and serum urate at the treatment target (<6 mg/dl) were associated with higher patient and physician gout control scores. Absence of tophus also predicted higher physician, but not patient, gout control scores. Discordant scores for gout control were present in 50 participants (22.3%), mostly due to lower assessment of disease control by physicians. Gout flare in the preceding 3 months (odds ratio [OR] 5.9, P < 0.001) and tophus (OR 3.1, P = 0.007) predicted discordant disease‐control assessments in which physicians scored lower gout control than patients.ConclusionFor both patients and physicians, absence of gout flares and serum urate levels at the treatment target predict assessment of gout control. However, discordance between patients and physicians in their assessment of disease control is not uncommon, with recent gout flares and tophus predicting lower scores by physicians than patients.
Adaptive observer design for uncertain nonlinear ODE‐PDE cascades
Authors: Benabdelhadi Abdeljalil , Giri Fouad , Krstic Miroslav , Chaoui Fatima‐Zahra , Rachid Kamal , El Fadil Hassan 
Published: October 2022

SummaryWe are revisiting the problem of adaptive observer design for systems that are constituted of an Ordinary Differential Equation (ODE), containing a globally Lipschitz function of the state, and a linear Partial Differential Equation (PDE) of a diffusion–reaction heat type. The ODE and PDE are connected in series and both are subject to parametric uncertainties. In addition to nonlinearity and uncertainty, the system complexity also lies in the fact that no sensor can be implemented at the junction point between the ODE and the PDE. In the absence of parameter uncertainty, nonadaptive state observers are available featuring exponential convergence. However, convergence is guaranteed only under the condition that either the Lipschitz coefficient is sufficiently small or the PDE domain length is sufficiently small. To get around this limitation, and also to account for parameter uncertainty, we develop a design that involves two concatenated adaptive observers, covering the two subintervals of the PDE domain. The proposed design employs one extra sensor, providing the measurement of the PDE state at an inner position close to the ODE‐PDE junction point. Both observers are shown to be exponentially convergent, under ad‐hoc persistent excitation (PE) conditions, with no limitation on the Lipschitz coefficient and domain length.
Mixing‐Induced Orientational Ordering in Liquid‐Crystalline Organic Semiconductors
Authors: Nikaido Kiyoshi , Inoue Satoru , Kumai Reiji , Higashino Toshiki , Matsuoka Satoshi , Arai Shunto , Hasegawa Tatsuo 
Published: October 2022

AbstractOrganic semiconductors (OSCs) often exhibit thermotropic liquid‐crystalline (LC) phases in which molecular orientational order is partially lost. The formation of a temporary LC state via a solution process is expected to promote printing‐based device production, although a method of controlling molecular ordering over LC states has not yet been developed. Here, it is demonstrated that long‐axis molecular ordering can be controlled under ambient conditions using unsymmetrically alkylated OSCs with high layered crystallinity. Introducing a small amount of OSC molecules with longer alkyl‐chain lengths leads to the conversion of the long‐axis disordered phase into a bilayer‐type ordered phase with improved hole mobility in the transistor characteristics. Analyses of the entropies of the transitions to the smectic LC phases at elevated temperatures demonstrate that the long‐axis molecular ordering can be driven by a balance between intralayer flip–flop motion and core–core interactions through LC phases. The proposed LC‐mediated solution processing paves the way toward high‐end printed electronics.
Injectable Polymer‐Nanoparticle Hydrogel for the Sustained Intravitreal Delivery of Bimatoprost
Authors: Meany Emily L. , Andaya Roxanne , Tang Shijia , Kasse Catherine M. , Fuji Reina N. , Grosskopf Abigail K. , d'Aquino Andrea L. , Bartoe Joshua T. , Ybarra Ryan , Shelton Amy , Pederson Zachary , Hu Chloe , Leung Dennis , Nagapudi Karthik , Ubhayakar Savita , Wright Matthew , Yen Chun‐Wan , Appel Eric A. 
Published: October 2022

AbstractVision impairment resulting from chronic eye diseases, such as macular degeneration and glaucoma, severely impacts patients’ quality of life and poses an immense global financial burden. Current standard of care for such diseases includes daily eye drops or frequent intravitreal (ITV) injections, which are burdensome treatment modalities resulting in low patient compliance. There remains a growing need for easily administered long‐acting delivery technologies for prolonging exposure of ocular therapeutics with each administration. Here, this work deploys a supramolecular polymer‐nanoparticle (PNP) hydrogel for ITV delivery of the glaucoma drug bimatoprost. PNP hydrogels are shear‐thinning and self‐healing, key properties for injectability, and enable slow release of molecular cargo in vitreous humor (VH) mimics. An in vivo study in New Zealand white rabbits demonstrated intravitreally injected PNP hydrogels form depots that degrade slowly over time, maintaining detectable levels of bimatoprost in the VH up to 8 weeks following injection. Ophthalmic examinations and histopathology identified a mild foreign body response (FBR) to the hydrogel, characterized by rare clusters of foamy macrophages and giant cells associated with minimal, patchy fibroplasia. This work shows that PNP hydrogels exhibit numerous desirable traits for sustained drug delivery and further work will be necessary to optimize tolerability in the eye.
Fewer COVID‐19 Neurological Complications with Dexamethasone and Remdesivir
Authors: Grundmann Alexander , Wu Chieh‐Hsi , Hardwick Marc , Baillie J. Kenneth , Openshaw Peter J M , Semple Malcolm G. , Böhning Dankmar , Pett Sarah , Michael Benedict D. , Thomas Rhys H. , Galea Ian ,   for the ISARIC4C investigators
Published: October 2022

ObjectiveThe objective of this study was to assess the impact of treatment with dexamethasone, remdesivir or both on neurological complications in acute coronavirus diease 2019 (COVID‐19).MethodsWe used observational data from the International Severe Acute and emerging Respiratory Infection Consortium World Health Organization (WHO) Clinical Characterization Protocol, United Kingdom. Hospital inpatients aged ≥18 years with laboratory‐confirmed severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) infection admitted between January 31, 2020, and June 29, 2021, were included. Treatment allocation was non‐blinded and performed by reporting clinicians. A propensity scoring methodology was used to minimize confounding. Treatment with remdesivir, dexamethasone, or both was assessed against the standard of care. The primary outcome was a neurological complication occurring at the point of death, discharge, or resolution of the COVID‐19 clinical episode.ResultsOut of 89,297 hospital inpatients, 64,088 had severe COVID‐19 and 25,209 had non‐hypoxic COVID‐19. Neurological complications developed in 4.8% and 4.5%, respectively. In both groups, neurological complications were associated with increased mortality, intensive care unit (ICU) admission, worse self‐care on discharge, and time to recovery. In patients with severe COVID‐19, treatment with dexamethasone (n = 21,129), remdesivir (n = 1,428), and both combined (n = 10,846) were associated with a lower frequency of neurological complications: OR = 0.76 (95% confidence interval [CI] = 0.69–0.83), OR = 0.69 (95% CI = 0.51–0.90), and OR = 0.54 (95% CI = 0.47–0.61), respectively. In patients with non‐hypoxic COVID‐19, dexamethasone (n = 2,580) was associated with less neurological complications (OR = 0.78, 95% CI = 0.62–0.97), whereas the dexamethasone/remdesivir combination (n = 460) showed a similar trend (OR = 0.63, 95% CI = 0.31–1.15).InterpretationTreatment with dexamethasone, remdesivir, or both in patients hospitalized with COVID‐19 was associated with a lower frequency of neurological complications in an additive manner, such that the greatest benefit was observed in patients who received both drugs together. ANN NEUROL 2023;93:88–102
Horseshoe crab egg availability for shorebirds in Delaware Bay: Dramatic reduction after unregulated horseshoe crab harvest and limited recovery after 20 years of management
Authors: Smith Joseph A. M. , Dey Amanda , Williams Karen , Diehl Theo , Feigin Stephanie , Niles Lawrence J. 
Published: October 2022

AbstractThe largest aggregation of spawning American horseshoe crabs in the world occurs in Delaware Bay and supports one of the largest concentrations of shorebirds in the western hemisphere where the birds feed on horseshoe crab eggs during migration. Unregulated harvest in the 1990s is associated with the decline of shorebird populations using the bay, but corresponding baseline information on the horseshoe crab egg food supply that supported peak shorebird populations has been lacking.Past and current measurements of horseshoe crab eggs in the bay indicate that abundance in the 1980s was an order of magnitude greater (x̄ = 156,600/m2) than present‐day estimates (2015–2021 x̄ = 10,243/m2). An additional egg prevalence index, which characterizes the timing and magnitude of horseshoe crab egg output, revealed a similar pattern of higher prevalence in the 1980s (0.89, 95% confidence interval 0.81–0.94) compared with the recent 2015–2021 interval (0.52, 95% confidence interval 0.43–0.60).Declines of egg and shorebird abundance occurred shortly after horseshoe crab harvest reached its peak. Red knot aerial survey counts have stabilized at 30% of the baseline population while ruddy turnstone counts are 40% of baseline estimates. Initially these species were evenly distributed between the New Jersey and Delaware coasts but both species have trended toward predominately occupying New Jersey beaches.A lack of recovery of horseshoe crab egg and shorebird abundance suggests that horseshoe crab harvest management has stabilized populations but progress toward population recovery has been limited. Impacts from bycatch, the pharmaceutical industry and other potential population impacts must be better quantified and mitigated, if necessary, to promote the recovery of horseshoe crab populations. Measurements of horseshoe egg prevalence and abundance are essential metrics for tracking the progress toward management goals for improving shorebird habitat quality.
Intrinsic Zinc in Brass Enables Lithium Anode Dendrite‐Free
Authors: Zhang Nianchao , Wang Jie , Yang Zhiyuan , Zhao Zheng , Wang Congwei , Wang Junying , Wang Junzhong 
Published: October 2022

AbstractBrass foil, composed of copper (Cu) and zinc (Zn), is a commercialized low‐cost Cu‐based matrix with lithiophilic properties. However, brass has never been employed as a current collector of lithium (Li) metal anode to suppress formation of Li dendrite. Here, we show that brass foil is directly utilized as a current collector for Li metal anodes. It exhibits a stable repeated Li plating and stripping for more than 400 h (200 cycles) with a low overpotential (∼0.018 V) and a capacity of 1 mAh cm−2 at a current density of 1 mA cm−2 in a symmetric cell, as well as a higher average Coulombic efficiency of 97.2 % for more than 120 cycles with a capacity of 1 mAh cm−2 at a current density of 0.5 mA cm−2. Thanks to the lithiophilicity of homogeneous Zn in brass, the nucleation overpotential of Li is effectively reduced and Li is uniformly deposited on the current collector without dendrite formation. Our investigation might inspire the ancient brass to apply to lithium‐ion battery.
Use of Monte Carlo simulations for improved facility fit planning in downstream biomanufacturing and technology transfer
Authors: Furcht Christopher , VanSeveren Michael , Holstein Melissa , Feroz Hasin , Ghose Sanchayita 
Published: October 2022

AbstractBiologics manufacturing is capital and consumable intensive with need for advanced inventory planning to account for supply chain constraints. Early‐stage process design and technology transfer are often challenging due to limited information on process variability regarding bioreactor titer, process yield, and product quality. Monte Carlo (MC) methods offer a stochastic modeling approach for process optimization where probabilities of occurrence for process inputs are incorporated into a deterministic model to simulate more likely scenarios for process outputs. In this study, we explore MC simulation‐based design of a monoclonal antibody downstream manufacturing process. We demonstrate that this probabilistic approach offers more representative outcomes over the conventional worst‐case approach where the theoretical minimum and maximum values of each process parameter are used without consideration for their probability of occurrence. Our work demonstrates case studies on more practically sizing unit operations to improve consumable utilization, thereby reducing manufacturing costs. We also used MC simulations to minimize process cadence by constraining the number of cycles per unit operation to fit facility preferences. By factoring in process uncertainty, we have implemented MC simulation‐based facility fit analyses to efficiently plan for inventory when accounting for process constraints during technology transfer from lab‐scale to clinical or commercial manufacturing.
Family physicians' involvement in palliative cancer care
Authors: Moon Christine C. , Mah Kenneth , Pope Ashley , Swami Nadia , Hannon Breffni , Lau Jenny , Mak Ernie , al‐Awamer Ahmed , Banerjee Subrata , Dawson Laura A. , Husain Amna , Rodin Gary , Le Lisa W. , Zimmermann Camilla 
Published: October 2022

AbstractBackgroundFamily physicians' (FPs) long‐term relationships with their oncology patients position them ideally to provide primary palliative care, yet their involvement is variable. We examined perceptions of FP involvement among outpatients receiving palliative care at a cancer center and identified factors associated with this involvement.MethodsPatients with advanced cancer attending an oncology palliative care clinic (OPCC) completed a 25‐item survey. Eligible patients had seen an FP within 5 years. Binary multivariable logistic regression analyses were conducted to identify factors associated with (1) having seen an FP for palliative care within 6 months, and (2) having a scheduled/planned FP appointment.ResultsOf 258 patients, 35.2% (89/253) had seen an FP for palliative care within the preceding 6 months, and 51.2% (130/254) had a scheduled/planned FP appointment. Shorter travel time to FP (odds ratio [OR] = 0.67, 95% confidence interval [CI] = 0.48–0.93, p = 0.02), the FP having a 24‐h support service (OR = 1.96, 95% CI = 1.02–3.76, p = 0.04), and a positive perception of FP's care (OR = 1.05, 95% CI = 1.01–1.09, p = 0.01) were associated with having seen the FP for palliative care. English as a first language (OR = 2.90, 95% CI = 1.04–8.11, p = 0.04) and greater ease contacting FP after hours (OR = 1.33, 95% CI = 1.08–1.64, p = 0.008) were positively associated, and female sex of patient (OR = 0.51, 95% CI = 0.30–0.87, p = 0.01) and travel time to FP (OR = 0.66, 95% CI = 0.47–0.93, p = 0.02) negatively associated with having a scheduled/planned FP appointment. Number of OPCC visits was not associated with either outcome.ConclusionMost patients had not seen an FP for palliative care. Accessibility, availability, and equity are important factors to consider when planning interventions to encourage and facilitate access to FPs for palliative care.
Noninvasive ventilation via bilevel positive airway pressure improved sleep in a child with congenital central hypoventilation syndrome: A case report
Authors: Yang Liqiang , Qiu Shuyao , Zhong Jianwen , Liu Dabo 
Published: October 2022

AbstractWe report the polysomnography findings of a 2‐year‐old girl who was previously diagnosed with CCHS and treated with bilevel positive airway pressure (BiPAP) and O2 supplementation for a year. The girl had convulsions 2 times in the last 10 days. After we replaced her nasal cannula with a nasal mask and adjusted the parameters of the BiPAP, her sleep and ventilation were improved. The polysomnographies measured under spontaneous breathing without oxygen supplementation showed that her sleep structure, heart rate, and oxygen saturation during sleep were improved 1 month and 1 year after effective BiPAP treatment.
A rare Danish case of Yersinia pseudotuberculosis pyogenic liver abscess
Authors: Dudina Margarita , Søgaard Kirstine K. , Deleuran Thomas , Joensen Katrine Grimstrup , Frøkjær Jens Brøndum , Nielsen Hans Linde 
Published: October 2022

AbstractYersinia pseudotuberculosis is a rare Gram‐negative bacillus that cause enterocolitis and terminal ileitis. We report the first Danish case with Y. pseudotuberculosis multiple pyogenic liver abscess presenting with 6 weeks intermittently fever, fatigue, and weight loss. The patient was successfully treated with percutaneous drainage and intravenous piperacillin/tazobactam and oral ciprofloxacin.
Tuberculous abdominal cocoon: A rare variant of peritonitis
Authors: Limaiem Faten , Omrani Sahir , Medhioub Fatma , Hajri Mohamed , Bayar Rached 
Published: October 2022

AbstractCocoon abdomen is an uncommon condition characterized by bowel entrapment in a cocoon‐like membrane. Its clinical presentation is usually non‐specific. Rarely, it may present with perforation peritonitis. The therapeutic approach depends on the stage of the disease. Surgery is essentially reserved for those with acute surgical complications.