bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatigue is a common symptom in myelin oligodendrocyte glycoprotein antibody disease
Authors: Ladakis Dimitrios C , Gould Jennifer , Khazen Jenny M , Lefelar Julia M , Tarpey Scott , Bies Charles J , Salky Rebecca , Fitzgerald Kathryn C , Bhargava Pavan , Nourbakhsh Bardia , Sotirchos Elias S 
Published: November 2022

Background Unlike multiple sclerosis and neuromyelitis optica, the burden of fatigue in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is unclear. Objective To compare fatigue levels between people with MOGAD and household controls (HC) and explore factors associated with fatigue severity. Methods In a cross-sectional survey, data were collected from people with MOGAD and HC by utilizing an online questionnaire. Data elements included demographics, sleep quality measures, comorbidities, MOGAD characteristics, and fatigue severity measured by the Modified Fatigue Impact Scale (MFIS). We compared fatigue severity between MOGAD participants and HC and assessed the associations between demographic and disease characteristics and fatigue severity. Results There were 180/283 MOGAD and 61/126 HC respondents. Compared to HC, people with MOGAD reported more severe fatigue, as measured by the MFIS total score (49.3 vs. 36.5; p < 0.001), and a larger proportion of MOGAD participants (75.6% vs. 44.3%; p < 0.001) were classified as fatigued. Among MOGAD participants, higher age ( p = 0.04), history of bilateral optic neuritis ( p = 0.02), and current use of acute treatment ( p = 0.04) were independently associated with higher fatigue. Conclusions Fatigue is common in people with MOGAD, and a history of bilateral optic neuritis, comorbid conditions, and ongoing disease activity appear to contribute to fatigue severity.
TElewoRk-RelAted Stress (TERRA), Psychological and Physical Strain of Working From Home During the COVID-19 Pandemic: A Systematic Review
Authors: Gualano Maria Rosaria , Santoro Paolo Emilio , Borrelli Ivan , Rossi Maria Francesca , Amantea Carlotta , Daniele Alessandra , Moscato Umberto 
Published: November 2022

Background: Many workers shifted to working from home due to the COVID-19 pandemic. This review aims to investigate if this sudden change caused an increase in TElewoRk-RelAted stress (TERRA) which is defined as physical and mental stress caused by telework. Methods: A systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was performed of three scientific databases (PubMed, ISI Web of Knowledge, and Scopus), which also included a quality assessment. Articles measuring stress, psychological or physical, in remote workers, published from December 2019 through August 2021 were included in the review. Results were extracted by reporting: authors, country, study design, type of workers, sample, questionnaires and measurements, and outcomes. Data were synthesized quantitatively for country, type of workers, and outcomes. Results: Out of the 518 articles found in the three databases, 19 articles were included in the systematic review (10,012 participants overall), and 78.9% of these highlighted an increase in TERRA levels in remote workers. Among 85.7% of the studies considering gender as a variable, TERRA levels were higher in female workers. Twelve (63.2%) of the studies investigated psychological well-being, two (10.5%) focused on the physical well-being of remote workers, three (15.8%) investigated both, and two studies had other outcomes (10.5%). Conclusions: Considering the redefinition of workplaces dictated by the COVID-19 pandemic, this review highlights the emerging issue of remote work and the use of technology in working from home, emphasizing a rapidly growing occupational health problem. Remote workers need to be provided with emotional and technical support to prevent TERRA in remote workers.
The Occurrence Parallelism of the 1st and 2nd Ray in Mid Foot Fracture Dislocations. A Review of 234 Cases
Authors: Mason Lyndon W. , Tanaka Hiro , Mangwani Jitendra , Airey Grace L. , Chapman James , Kyaw Htin , Boksh Khalis , Elbannan Mamdouh M. 
Published: November 2022

Category: Trauma Introduction/Purpose: The parallel nature of the 1st and 2nd metatarsal has been reported in Lisfranc type injuries to the midfoot, reportedly the result of the lateral and dorsal subluxation of the 2nd metatarsal base. In this study, our aim was to explore the prevalence of parallelism in midfoot injuries and the associated features. Methods: Setting: Multicentre observational study Methods: Data was retrospectively collected from three centres on surgically treated midfoot fracture dislocations between 2011 and 2021. Radiographs were analysed using departmental PACS. Parallelism was defined as a 1/2 intermetatarsal angle of less than 6. All statistics was performed using SPSS 26. Results: A total of 234 cases were included in the study. All 234 had undergone non-weightbearing (NWB) radiographs, with 80 patients who had also undergone (WB) weightbearing radiographs. The prevalence of parallelism was 21.3% (17/80) in the WB radiographs and 20.1% (47/234) in the NWB radiographs. The average IMA in the non-parallel group was 9.45 (95% CI 9.12,9.77) and 4.18 (95% CI 3.78, 4.57) in the parallel group. Concomitant lateral column injury was the only factor with a significant association with parallelism (p=.015). Other factors such as bone or ligamentous injury (p=.657), medial column injury (p=.085) and central column injury (p=.323) did not have a significant association. Conclusion: Parallelism in midfoot fracture dislocations occurs in approximately 20% of cases. If present, a high index of suspicion to the presence of a lateral column injury should be maintained due to its significant association.
Peritalar Configuration Following Fusion in Varus Ankle Osteoarthritis: A 3D Weight Bearing CT Analysis
Authors: Mitsui Hiroyuki , Mehdi Nazim , Bernasconi Alessio , Fernando Céline , Karube Tomoko , Niki Hisateru , Lintz Francois 
Published: November 2022

Category: Ankle Arthritis; Ankle Introduction/Purpose: In varus-type osteoarthritis of the ankle (VAOA), it is known that the subtalar joint compensates in valgus/eversion for the malalignment of the tibiotalar joint. However, previous studies were mainly based on X-ray measurements and did not take into account peri-talar changes that extend to the subtalar and Chopart joints. Furthermore, the effect on peritalar compensation when tibio-talar arthrodesis is performed is still unclear. Distance Mapping (DM) is a technology that can produce a 3D point-to-point distance map of joint interactions from cone beam weight bearing CT (WBCT) images. The purpose of this study was to quantify the peri-talar changes that occur when the tibiotalar joint is fused. We hypothesized that talar varus would improve and that the Chopart/Subtalar joint complex would present compensatory varus/inversion. Methods: The subjects were 14 patients (15 feet) who underwent arthrodesis for VAOA at our institution. The average postoperative follow-up period was 6.6 months. Foot alignment (Foot Ankle Offset (FAO)) was measured from WBCT datasets pre and postoperatively. The pre to post op shift vectors of the weighted distance maps center points were measured for the tibiotalar, subtalar, calcaneocuboid and talonavicular joints. Statistical analysis was performed by paired T-test, and the significance level set at p<0.05. Results: FAO improved significantly from preoperative -12.9 +-7.4 % to postoperative -6.4 +-3.9 %. The DM vectors were 4.9 +-2.8 mm (lateral direction) for the tibiotalar joint, 0.86 +-0.93 mm (posterior) for the subtalar joint and 4.9 +-2.6 mm (plantar- medial) for the talonavicular joint. Conclusion: The main finding in this study was that foot alignment was improved following tibiotalar arthrodesis with peritalar compensation, more so in the talonavicular than in the subtalar joint and not in the calcaneocuboid joint. The limitations of this study include the small number of cases and the short postoperative follow-up. Our results suggest that the flexibility of the talonavicular joint may be necessary when arthrodesis is performed on VAOA to contribute to the alignment correction. If it is not the case, TAR could be considered an alternative.
Incidence and Functional Impact of Floating Toe after Distal Metatarsal Minimal Invasive Osteotomy Compared to Open Modified Weil Osteotomy
Authors: Mocoçain Mac-iver Pablo E. , Valderrama Carlos , Radkievich Ruben D. , Elgueta Stephane , Salinas David A. , Díaz Andres Keller , Zanolli de Solminihac Diego H. 
Published: November 2022

Category: Lesser Toes; Hindfoot Introduction/Purpose: Distal metatarsal osteotomies for metatarsalgia are one of the most frequent procedures in foot and ankle surgery, however, sometimes their results are not so favorable, with sequelae such as floating toe or loss of toe grip. The open modified Weil osteotomy (OWO) is considered the first alternative in metatarsalgia cases for many surgeons, nevertheless, in recent years, minimally invasive surgery (MIS) has become an attractive alternative for the management of this pathology. To date, there is scarce literature that compares clinical and functional results between both techniques. The objective of this study is to compare the clinical and functional outcomes between OWO and minimally invasive distal metatarsal osteotomy (DMMO), with and without lesser toe procedures. Methods: We performed a retrospective review of 77 patients who underwent OWO or DMMO, with at least 12 month follow up. We excluded patients with incomplete data, previous forefoot surgery, and patients with neuromuscular or rheumatological diseases. Our main outcome was to evaluate the presence of floating toe. Our secondary outcomes were to evaluate toe grip strength (paper pullout test), functional scores (LEFS and AOFAS) and satisfaction. All patients were clinically evaluated by one foot and ankle surgeon who did not participate in any of the surgical procedures. Statistical analysis was performed using Student's t-test, Fisher's test, and Chi-square. Results: 77 patients (188 rays) were included. 120 rays received OWO, and 68 rays DMMO. 95% women, with a mean age of 57 years. The mean follow-up was 39.4 months. The floating toe incidence was 56.7% in the OWO group (67.3% when a DuVries procedure was added), which was significantly higher (p=0.001) than the 25% in the DMMO group (37.9% when P1 MIS osteotomy was added). When comparing lesser toe grip strength between both groups, the DMMO patients had significantly greater grip strength (p=001) Significant differences were obtained between both groups when comparing satisfaction (p=0.04), LEFS (p=0.001), and AOFAS scores (p=0.001), being better in the DMMO group. Conclusion: In our series, the DMMO procedure had significantly lower incidence of floating toe, greater toe grip strength, better functional outcomes and superior satisfaction scores than the OWO. When a bone procedure in the lesser toe is added (MIS osteotomy or DuVries) the floating toe incidence is increased, but not with statistical significance.
Burden of respiratory syncytial virus infection in older and high-risk adults: a systematic review and meta-analysis of the evidence from developed countries
Authors: Nguyen-Van-Tam Jonathan S. , O'Leary Maureen , Martin Emily T. , Heijnen Esther , Callendret Benoit , Fleischhackl Roman , Comeaux Christy , Tran Thao Mai Phuong , Weber Karin 
Published: November 2022

BackgroundRespiratory syncytial virus (RSV) significantly impacts the health of older and high-risk adults (those with comorbidities). We aimed to synthesise the evidence on RSV disease burden and RSV-related healthcare utilisation in both populations.MethodsWe searched Embase and MEDLINE for papers published between 2000 and 2019 reporting the burden and clinical presentation of symptomatic RSV infection and the associated healthcare utilisation in developed countries in adults aged ≥60 years or at high risk. We calculated pooled estimates using random-effects inverse variance-weighted meta-analysis.Results103 out of 3429 articles met the inclusion criteria. Among older adults, RSV caused 4.66% (95% CI 3.34–6.48%) of symptomatic respiratory infections in annual studies and 7.80% (95% CI 5.77–10.45%) in seasonal studies; RSV-related case fatality proportion (CFP) was 8.18% (95% CI 5.54–11.94%). Among high-risk adults, RSV caused 7.03% (95% CI 5.18–9.48%) of symptomatic respiratory infections in annual studies, and 7.69% (95% CI 6.23–9.46%) in seasonal studies; CFP was 9.88% (95% CI 6.66–14.43%). Data paucity impaired the calculation of estimates on population incidence, clinical presentation, severe outcomes and healthcare-related utilisation.ConclusionsOlder and high-risk adults frequently experience symptomatic RSV infection, with appreciable mortality; however, detailed data are lacking. Increased surveillance and research are needed to quantify population-based disease burden and facilitate RSV treatments and vaccine development.
Evaluation of word embedding models to extract and predict surgical data in breast cancer
Authors: Sgroi Giuseppe , Russo Giulia , Maglia Anna , Catanuto Giuseppe , Barry Peter , Karakatsanis Andreas , Rocco Nicola ,   ETHOS Working Group, Pappalardo Francesco 
Published: November 2022

Abstract
Background
Decisions in healthcare usually rely on the goodness and completeness of data that could be coupled with heuristics to improve the decision process itself. However, this is often an incomplete process. Structured interviews denominated Delphi surveys investigate experts' opinions and solve by consensus complex matters like those underlying surgical decision-making. Natural Language Processing (NLP) is a field of study that combines computer science, artificial intelligence, and linguistics. NLP can then be used as a valuable help in building a correct context in surgical data, contributing to the amelioration of surgical decision-making.

Results
We applied NLP coupled with machine learning approaches to predict the context (words) owning high accuracy from the words nearest to Delphi surveys, used as input.

Conclusions
The proposed methodology has increased the usefulness of Delphi surveys favoring the extraction of keywords that can represent a specific clinical context. It permits the characterization of the clinical context suggesting words for the evaluation process of the data.
A longitudinal study of humoral immune responses induced by a 3-dose inactivated COVID-19 vaccine in an observational, prospective cohort
Authors: Tao Yue , Ma Mengyin , Hu Fenghua , Li Ming , Geng Yu , Wan Yawen , Mao Minxin , Chen Lin , Shen Ya , Zhu Liguo , Shen Han , Chen Yuxin 
Published: November 2022

Abstract
Background
To determine the dynamic SARS-CoV-2 specific antibody levels induced by 3 doses of an inactivated COVID-19 vaccine, CoronaVac. An observational, prospective cohort study was performed with 93 healthy healthcare workers from a tertiary hospital in Nanjing, China. Serum SARS-CoV-2 specific IgM, IgG, and neutralizing antibodies (NAb) were measured at different time points among participants who received 3 doses of inactivated COVID-19 vaccine.

Results
91.3% (85/93) and 100% (72/72) participants showed positive both for SARS-CoV-2 specific IgG and NAb after 2-dose CoronaVac and after 3-dose CoronaVac, respectively. Anti-SARS-CoV-2 IgG responses reached 91.21 (55.66–152.06) AU/mL, and surrogate NAb was 47.60 (25.96–100.81) IU/mL on day 14 after the second dose. Anti-SARS-CoV-2 IgG responses reached 218.29 (167.53–292.16) AU/mL and surrogate NAb was 445.54 (171.54–810.90) IU/mL on day 14 after the third dose. Additionally, SARS-CoV-2 specific surrogate neutralizing antibody titers were highly correlated with serum neutralization activities against Ancestral, Omicron, and Delta strains. Moreover, significantly higher SARS-CoV-2 IgG responses, but not NAb responses, were found in individuals with breakthrough infection when compared to that of 3-dose CoronaVac recipients.

Conclusions
CoronaVac elicited robust SARS-CoV-2 specific humoral responses. Surrogate NAb assay might substitute for pseudovirus neutralization assay. Monitoring SARS-CoV-2 antibody responses induced by vaccination would provide important guidance for the optimization of COVID-19 vaccines.
The application of magnetic anchoring traction device in assisting donor liver bench surgery in classic orthotopic liver transplantation
Authors: Song Jiashu , Wang Yue , Cai Xianming , Shi Jianhua , Hu Liangshuo , Chang Pengkang , Zhang Wei , Tang Bo , Lv Yi , Zhang Xiaogang 
Published: November 2022

Abstract
Objective
To explore the clinical application of a newly developed magnetic anchoring traction (MAT) system in the liver bench trimming and transplantation surgery.

Background
The conventionally limited space, vision, and exposure have always been a challenge for the quality of surgery in the liver bench trimming due to the fact that the exposure depends largely on the experience of surgeon. To deal with this problem, a MAT system is developed as an alternative support to enhance exposure. The preliminarily experiments on animals verified its feasibility and reliability in the practical use, and its clinical application and effects were examined in the present research.

Methods
A total of 20 DCD (donation of cardiac death) donor livers were collected and divided evenly between the magnetic anchor traction (MAT) assisted group (n = 10) and the manual assisted group (n = 10). The results and quality assessment from experts about the liver bench surgery performed by two groups were examined and compared.

Results
The MAT system can be employed effectively to compete and replace the manual assistance to achieve a better exposure in the liver bench trimming. No statistical difference was found regarding the baseline data between the MAT and the manual groups. In the inferior vena cava and hepatic artery trimming, the MAT group outperformed the manual group remarkably in many aspects. The surgery time for liver bench shortened considerably after a quick grasp of MAT skills by surgeons.

Conclusion
The MAT system provides a more stable, reliable and qualified local exposure in the liver bench surgery, and can preferably be employed to replace the manual assistance in the procedures of liver transplantation.
Comparison of efficiency and safety between dual-clip and rubber band-assisted ESD and conventional ESD for colonic lateral spreading tumors (LSTs) with different levels of technical difficulty: a retrospective case–control study
Authors: Ma Xingbin , Ma Huaiyuan , Gao Tao , Cao Jingrun , Liu Chengxia , Niu Qiong 
Published: November 2022

Abstract
Background
Dual-clip and rubber band-assisted endoscopic submucosal dissection (DCRB-ESD) is a useful technique in the management of lateral spreading tumors (LSTs) of the colon and is suggested by researchers compared with conventional ESD (C-ESD). The aim of this retrospective study is to further analyze the efficiency and safety of DCRB-ESD in a setting with varying technical difficulties.

Methods
Patients who underwent endoscopic treatment (DCRB-ESD or C-ESD) due to LSTs between Jan 1st, 2019 and Jan 1st, 2022, were retrospectively collected. Patients were classified into the following two groups: the DCRB-ESD group (n = 46) and the C-ESD group (n = 81). Baselines were compared and propensity score matching (PSM) was employed to manage the heterogeneity. The technical difficulty and outcomes of the two groups were evaluated based on a semiquantitative model (CS-CRESD) previously described.

Results
The baseline characteristics of the two groups were balanced except sex and LST classification before PSM and were corrected after PSM. The median ESD operation time of DCRB-ESD was shorter than that of C-ESD (32 vs 41 and 30 vs 44 before and after PSM respectively, P < 0.05). The operation durations of cases with different CS-CRESD scores were different (P < 0.05). In the subgroup with a score of 0, DCRB-ESD showed no advantage than C-ESD in terms of operation duration before and after PSM. In subgroups with a score of 1–3, DCRB-ESD was faster than C-ESD. In subgroups with a score of 4–5, the between-group operation duration was not significantly different due to the limited number of cases, although the median time of DCRB-ESD was shorter. The R0 resection rates, curative resection, complications, and additional surgery in both groups were not significantly different. No adverse events, such as a clip falling off or rubber band rupturing occurred during this study.

Conclusion
DCRB-ESD was an efficient and safe procedure in the management of colonic LSTs. With DCRB-ESD, the operation duration of difficult cases can be shortened without sacrificing complication risk. However, not all cases would benefit from DCRB-ESD. For easy cases (CS-CRESD score = 0), DCRB-ESD may not be prior to C-ESD by experienced endoscopists. A pre-ESD technical difficulty evaluation was recommended to decide whether to perform DCRB-ESD or not.
Walking a mile in Grandma’s shoes - medical students’ evaluation of a very simple online aging game to enhance their understanding of older patients
Authors: Geier Anne-Kathrin , Lippmann Stefan , Rau Antje , Schrimpf Anne , Bleckwenn Markus , Deutsch Tobias 
Published: November 2022

Abstract
Background
Aging simulation games are established educational interventions to make older patients’ perspectives noticeable, raise awareness about their needs, and positively influence attitudes toward older adults. Due to the COVID-19 pandemic restrictions imposed on education, we replaced a classroom-based aging simulation course with a simple online equivalent. This consisted of short introductory screencasts, four downloadable Portable Document Format (PDF) files containing issue-specific audio and video links, quizzes, case studies, and prompts for reflection. We explored how well our self-directed simple online simulation succeeded in providing students with relevant insights and experiences, raising awareness about age-related difficulties, and enhancing understanding of older patients.

Methods
In this cross-sectional study, an anonymous post hoc online survey was conducted among 277 5th-year medical students eligible for the course at the Leipzig University in May 2020. The questionnaire addressed overall course evaluations, assessments of the individual PDF components (working enjoyment, personal insights, professional learning gain, enhanced understanding, increased interest in working with older patients), and students’ main insights from the course (free text). Descriptive statistical and qualitative content analyses were performed.

Results
The response rate was 92.4% (n = 256, mean age 25.7 ± 3.4 years, 59.8% women). Nearly all respondents reported that the course was well structured, easily understandable, and that processing was intuitive. The majority (82.8%) perceived the course as practice-oriented, 88.3% enjoyed processing, 60.3% reported having gained new professional knowledge, and 75.4% had new personal insights. While only 14.8% agreed that the online course could generally replace the real-world simulation, 71.1% stated that it enabled them to change their perspective and 91.7% reported enhanced understanding of older patients. PDF components containing audio and video links directly imitating conditions (visual or hearing impairment) were rated highest. Qualitative data revealed manifold insights on the part of the students, most frequently referring to aspects of professional doctor-patient interaction, knowledge about conditions and diseases, role reversal, and enhanced empathy.

Conclusion
Simple online aging simulations may be suitable to provide students with relevant insights and enhance their understanding of older patients. Such simulations could be alternatively implemented in health professionals’ education where resources are limited.