bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a prognostic nomogram for patients with stage II colon mucinous adenocarcinoma
Authors: Huang Jia , zhang Yiwei , zhou Jia , Fang Min , Wu Xiaofeng , Luo Yuhang , Huang Qiulin , Ouyang Yujuan , Xiao Shuai 
Published: August 2022

Abstract
Purpose
Mucinous histology is generally considered as a risk factor of prognosis in stage II colon cancer, but there is no appropriate model for prognostic evaluation and treatment decision in patients with stage II colon mucinous adenocarcinoma (C-MAC).
Methods
Patients with stage II C-MAC who underwent surgical treatment in the Surveillance, Epidemiology, and End Results Program were enrolled and randomly divided into training cohort (70%) and internal validation cohort (30%). Prognostic predictors which were determined by univariate and multivariate analysis in the training cohort were included in the nomogram. The calibration curves, decision curve analysis, X-tile analysis, and Kaplan-Meier curve of the nomogram were validated in the internal validation cohort.
Results
3762 patients of stage II C-MAC were enrolled. The age, pathological T (pT) stage, tumor number, serum carcinoembryonic antigen (CEA), and perineural invasion (PNI) were independent predictors of overall survival (OS), which were used to establish a nomogram. Calibration curves of the nomogram indicated good consistency between nomogram prediction and actual survival for 1-, 3- and 5-year OS. Besides, patients with stage II C-MAC could be divided into high-, middle- and low-risk subgroups by the nomogram. Further subgroup analysis indicated that patients in the high-risk group could have a survival benefit from chemotherapy after surgical treatment.
Conclusions
We established the first nomogram to accurately predict the survival of stage II C-MAC patients who underwent surgical treatment. In addition, the nomogram identified low-, middle- and high-risk subgroups of patients and found chemotherapy might improve survival in the high-risk subgroup of stage II C-MAC patients.
Demonstration of a Fast-training Feed-forward Machine Learning Algorithm for Studying Key Optical Properties of FBG and Predicting Precisely the Output Spectrum
Authors: Dey Koustav , Nikhil Vangety , Chaudhuri Partha Roy , Roy Sourabh 
Published: August 2022

Abstract
In this article, we propose and demonstrate a generalized machine learning (ML) approach to analyse the various optical properties of the Fiber Bragg grating (FBGs), namely effective refractive index, bandwidth, reflectivity and wavelength. For this purpose, three commonly used variants of FBG, namely conventional, π phase-shifted and chirped ones are investigated and the reflected spectra of the aforementioned FBGs are predicted using ab initio artificial neural networks (ANNs). We implemented a simple and fast-training feed-forward ANN and established the efficacy of our model by predicting the output spectrum with minute details for unknown device parameters along with non-linear and complex behaviour of the spectrum. Thus, our proposed ANN model is capable of predicting various key optical properties and reproducing the exact spectrum accurately and quickly, providing a cost-effective solution for efficient and precise modelling.
Crossover fatigue after unilateral submaximal eccentric contractions of the knee flexors involves peripheral alterations and perceived fatigue
Authors: Gioda Jennifer , Monjo Florian , Silva Flavio Da , Corcelle Baptiste , Piponnier Enzo , Bredin Jonathan , Colson Serge S. 
Published: August 2022

Abstract
After a unilateral muscle exercise, the performance of the non-exercised contralateral limb muscle can be also impaired. This crossover fatigue phenomenon is still debated in the literature and very few studies have investigated the influence of eccentric contractions. This study was designed to assess neuromuscular adaptations involved in the crossover fatigue of the non-exercised contralateral hamstrings. Seventeen healthy young men performed a unilateral submaximal eccentric exercise of the knee flexors until a 20% reduction in maximal voluntary isometric contraction (MVIC) torque was attained in the exercised limb (EL). Before, immediately after exercise cessation (POST) and 24 hours later, neuromuscular function, global perceived fatigue and perceived muscle soreness were measured in both the EL and non-exercised limb (NEL). At POST, significant reductions in MVIC were observed in the EL (-28.1%, p < 0.001) and in the NEL (-8.5, p < 0.05). Voluntary activation decreased (-6.0, p < 0.05) in the EL only, while potentiated doublet torque were impaired (Dt100Hz -11.6%, p < 0.001 and Dt10Hz -8.1%, p < 0.05) in both the EL and the NEL. Global perceived fatigue significantly increased at POST (p < 0.001). Interestingly, peripheral alterations and global perceived fatigue may account for the crossover fatigue observed immediately after the exercise in the NEL possibly involving systemic adaptations.
Lactoferrin gene polymorphisms associated with clinical mastitis in Honduran Holstein cattle
Authors: Moncada-Laínez Marielena , Valladares-Medina Pablo Alejandro , Castillo Rogel , Rosa-Reyna Xochitl Fabiola De la , Sifuentes-Rincón Ana María , Moreno-Medina Victor Ricardo , Lara-Rivera Ana Laura , Parra-Bracamonte Gaspar Manuel 
Published: August 2022

Abstract
BackgroundLactoferrin (LTF) is an iron-binding glycoprotein found in milk and other exocrine secretion with antibacterial activity proposed as an alternative to mastitis treatment or prevention. LTF has been proposed as a candidate gene for mastitis resistance selection. The aim of this paper was to assess LTF promotor to explore variations with potential association to mastitis resistance in dairy cows from Honduras.MethodsA resequencing of promotor and Exon I of LTF gene in extreme mastitis susceptibility cows (126 Holstein and Holstein crossbred) was performed. ResultsEight polymorphisms were found in promotor region, four of them were novel variations. Two were important by frequency among extreme groups, but a polymorphism in -421 A/T position was significantly (P=0.0188) associated to mastitis susceptibility. ConclusionResults support the key role of regulatory region of LTF gene. Some candidate genes are proposed in association with mastitis traits and implications are discussed.
Electron Impact Ionization Cross-sections of CH3 and SiH3 Radicals Targets﻿
Authors: Kumar Manoj 
Published: August 2022

Abstract
Single differential cross sections as a function of secondary electron energy at fixed incident electron energies 100 and 200 eV for the targeted molecule CH3 and SiH3 have been evaluated by using a modified Jain-Khare semiempirical approach. The integral or total electron-impact ionization cross-sections and the averaged secondary electron energy from differential ionization cross sections are calculated for incident electron energy from ionization threshold to 5 keV regime. The temperature dependent ionization rate coefficient is also calculated using total ionization cross-sections and Maxwell-Boltzmann distribution of electron energy. The calculated values of total ionization cross sections corresponding to (e, 2e) processes for CH3 and SiH3 molecules are in good accord with available theoretical and experimental results.
Investigation on Optimization of Mechanical Properties of Bagasse Reinforced Epoxy Composite Using Grey Relational Analysis
Authors: KUMAR D K MOHAN , UDAIYAKUMAR K C 
Published: August 2022

Abstract
In this present study, the fabrication of polymer composite matrix has been designed using the epoxy matrix and bagasse fibre. The most crucial operating parameters such as chemical treatment, volume fraction of fibre content, concentration of chemical, and soaking hours of fibre in the chemical were evaluated. Based on these parameters, the outcomes such as tensile strength, flexural strength, impact strength, hardness, inter laminar shear strength, and coefficient of friction were measured and evaluated. The optimization of all the operating parameters against the various outcome parameters has been performed by Grey relational analysis. The analysis assist in making decision to select the best optimum parameters by assigning the rank for the combined mechanical properties with respect to different operating input variables. The optimum combination of operating parameters determined was (i) chemical treatment – KMnO4 (ii) Volume fraction of fibre content – 30 wt % (iii) Concentration of chemical – 7% and (iv) soaking hours of fibre – 6 hours.
Extended endoscopic transsphenoidal surgery with total cyst wall decollement for suprasellar cystic craniopharyngioma
Authors: Liu Jie , Wang Junwei , Wang Pan , Tang Chao , Jiang Haotian , Zhang Gang , Tan Xiaorong , Pan Jinyu , Wu Nan 
Published: August 2022

Abstract
Background: For most cystic craniopharyngiomas, intracapsular debulking is a good strategy to get a large operation space and protect vital structures. However, this surgical strategy may lead to the residual and recurrence of the tumor capsule wall. Therefore, there is an urgent need for a new surgical strategy without residual capsule walls for the removal of cystic craniopharyngiomas.Case Report: We reviewed a 45-year-old male with vision loss and visual field defects, whose head MRI revealed a suprasellar cystic lesion. The patient underwent extended endoscopic transsphenoidal surgery. The surgical strategy of total cystic wall decollement was adopted, which was that the lesion surrounded by the capsule was completely separated from the surrounding tissue without destroying the capsule and maintaining the tension of the capsule. The lesion was totally resected and pathological findings confirmed the diagnosis of craniopharyngioma. After the operation, both the visual acuity and pituitary function were significantly improved. In addition, he suffered from transient diabetes insipidus, which was subsequently relieved. During the 33-month follow-up, there was no tumor recurrence. Conclusion: Compared with the traditional surgical strategy of intracapsular debulking, the surgical strategy of total cystic wall decollement has the advantages of less residual tumor capsule, low tumor recurrence rate, etc. Therefore, for cystic craniopharyngiomas with an intact capsule or even other cystic tumors with an intact capsule, the surgical strategy of total cystic wall decollement may be an effective surgical strategy to reduce tumor recurrence.
Fatal pneumonitis associated with immune checkpoint inhibitors: a study based on 128 cohorts with 26,994 participants
Authors: Wu Chunlan , Wan Luying , Xie Xianhe 
Published: August 2022

Abstract
Background: With the widespread application of immune checkpoint inhibitors (ICIs), the immune-related adverse events (irAEs) were increasingly reported. Checkpoint inhibitor pneumonitis (CIP) was a frequent irAE with high mortality. Hence it is crucial to estimate the frequency and susceptible factors of fatal CIP.Methods: PubMed, Embase and Cochrane Library were searched for relevant studies that assessed fatal CIP. Primary endpoints were the incidence and susceptible factors of fatal CIP.Results: A total of 173 cases of fatal CIP occurred in 128 cohorts. The overall incidence was 0.96% [95% confidence interval (CI): 0.80-1.14%]. The odds and incidence were remarkably higher in hematologic malignancy group (compared with solid tumors) [3.86 vs. 0.90, odds ratio (OR): 2.41, 95% CI: 1.10-5.28, P=0.028], and in ≥2 line treatment group (compared with first line treatment group) [1.29 vs. 0.74, OR: 1.76, 95% CI: 1.24-2.44, P=0.001]. Meanwhile, the frequency was significantly decreased in phase Ⅲ trial group (compared with that of phase Ⅰ/Ⅱ trial group) [ 0.56 vs. 1.69 , OR: 0.37, 95% CI: 0.26-0.53, P＜0.0001].Conclusions: The overall incidence of fatal CIP was 0.96%. The susceptible factors of fatal CIP were hematologic malignancy, phase Ⅰ/Ⅱ trial, and ≥2 line treatment group. The study provided a capability for clinicians to predict and discriminate high-risk populations of fatal CIP.
Leukoencephalopathy in Patients with Brain Metastases Who Received Radiosurgery With or Without Whole Brain Radiotherapy
Authors: Liu Chan-Wei , Yang Huai-Che , Chiang Chi-Lu , Shen Chia-I , Wu Hsiu-Mei , Luo Yung-Hung , Hu Yong-Sin , Lin Chung-Jung , Chung Wen-Yuh , Shiau Cheng-Ying , Guo Wan-Yuo , Pan Hung-Chi , Lee Cheng-Chia 
Published: August 2022

Abstract
BackgroundWhole brain radiation therapy (WBRT) for brain metastases (BMs) is a common cause of radiation-induced leukoencephalopathy; however the safety of alternative stereotactic radiosurgery (SRS) remains unclear. This study examined the incidence of leukoencephalopathy in patients treated with SRS alone versus WBRT plus SRS for BMs with a focus on the relationship between prognostic factors and leukoencephalopathy.MethodsAnalysis was performed between 2002 and 2021. The total enrollment was 993 patients with the distribution: WBRT plus SRS (n=291) and SRS only (n=702). Leukoencephalopathy was graded from 0 to 3 for changes in white matter indicated by the MRI after WBRT or SRS. Patient characteristics and SRS dosimetric parameters were reviewed to identify factors that contributed to the incidence of leukoencephalopathy or overall survival.ResultsThe incidence of leukoencephalopathy was consistently higher in WBRT plus SRS group than in SRS alone group (p＜0.001). Leukoencephalopathy was also associated with a larger total tumor volume (≧28cm3; p=0.028) and age (＞77 years; p=0.025). Nonetheless, the SRS integral dose to skull in the subgroup of WBRT plus SRS treatment was not demonstrated significance in development of leukoencephalopathy (p=0.986 for integral dose 1-2J, p=0.776 for integral dose＞2J).ConclusionsThis study revealed that SRS is safe for oligo-BMs in terms of leukoencephalopathy development. Patient age and total tumor volume were identified as important factors in assessing the development of leukoencephalopathy. The additional of SRS (even at an integral dose＞2J) did not increase the incidence of leukoencephalopathy.
Nurses’ Barriers to Evidence-Based Practice in Palliative Care
Authors: Dakka Falah Jamal 
Published: August 2022

Abstract
Background
Research shows low EBP uptake among palliative care nurses, which is a global concern because the demand for palliative care services is rising, raising the urgent need to improve healthcare quality. Promoting EBP uptake in palliative care can improve healthcare quality. This systematic review investigated nurses’ barriers to EBP implementation in palliative care.
Method
PubMed and Google Scholar were used to identify six articles. Articles were included for review if published within the past ten years (English-only) and investigated barriers to EBP implementation in palliative care.
Results
Four barriers were identified: (a) time and resource constraints, (b) lack of readiness for organisational change, (c) negative attitudes towards palliative care, and (d) process-specific difficulties.
Conclusion
The findings of this systematic review can be used to inform policy changes to improve the uptake of EBP in palliative care.
Reflections on conducting Peer-Led Qualitative Research in British Columbia, Canada during COVID-19 Pandemic
Authors: Mehta Amiti , Fleury Mathew , Spence Heather , Lamb Jessica , McDougall Jenny , Buxton Jane A 
Published: August 2022

Abstract
In the province of British Columbia, illicit drug toxicity (overdose) deaths have increased during the Coronavirus Disease 2019 (COVID-19) pandemic. Prior evidence suggests that engagement of people with lived and living experience (PWLLE) of substance use, often referred to as peers, in research and policy development is essential to ensure the development of comprehensive and relevant harm reduction interventions addressing the requirements of the PWLLE. Public health measures introduced due to COVID-19 have intensified barriers in engaging PWLLE in research settings. This article presents the challenges encountered in conducting peer-led research in BC and the ways in which these challenges were addressed in the context of a province-wide research project initiated by the British Columbia Centre for Disease Control.
Exploring the Evolution of the Topics and Emerging Trends of MRI in Breast Cancer: A Bibliometric Analysis From 2000 to 2021
Authors: Su Yanbing , Cao Yujuan , Xing Jun , Li Hui , Guo Dongqiang 
Published: August 2022

Abstract
Objective: This study aims to provide a systematic and complete knowledge map for research trend and collaboration status within the field of magnetic resonance imaging (MRI) and breast cancer.Methods: Using the WOS database, 6640 articles were obtained through search strategies which were published from 2000 to 2021 in the field of MRI and breast cancer. The exported data were analyzed utilizing specific parameters with the help of bibliometric and science mapping software: VOSviewer and Gephi.Results: The publication output in the field of MRI and breast cancer growth steadily over the past two decades and it varied from different countries with the USA being far ahead of other countries. The paper output and international collaboration are mainly distributed in some countries like the USA, China and Germany. The Memorial Sloan Kettering Cancer Center, University of California San Francisco and MD Anderson Cancer Center have high academic influence in the field of MRI and breast cancer. Keywords mining reveals that deep learning, radiomics, convolutional neural network, artificial intelligence, nomogram, machine learning and radiogenomics are the research hotspots in the MRI and breast cancer related literature in recent years.Conclusion: This bibliometric study used a massive volume of bibliographic data to decipher the develop status, research collaboration, along with the research frontier and hotspot in the field of MRI and breast cancer. In this way, we provide insights into overall landscape of the literature and locate pertinent information for research interests of related scholars.
Geographical restriction and body size variation in two sibling species of flower-breeding Drosophila
Authors: Firdaus Anggun Sausan , Lin Yu-Wei , You Kai-An , Negi Ateesha , Kurniawan Nia , Wicaksono Karuniawan Puji , Tarno Hagus , Yeh Shu-Dan 
Published: August 2022

Abstract
Background:Variations in body size and body melanization are thought to be important features for local adaptation of environmental stresses in many insects and latitudinal clines of such variation have been found many taxa. When two species share similar resource, ecological divergence and niche partitioning may further evolve as the consequence of competition. Here, we examined the distribution, host plant usage, and body size variation of two closely-related species, Drosophila elegans, which has two discrete body color morphs, and D. gunungcola on three islands. Results:The brown morph of D. elegans has a similar distribution to D. gunungcola in Java and Sumatra, whereas the black morph of D. elegans is exclusively found in Taiwan. A significant correlation between latitudes and altitudes was found in sites where D. gunungcola was found in Sumatra south of equator. The brown morph of D. elegans was found to be smaller in body size and tends to live in warmer habitat compared to the black morph of D. elegans and D. gunungcola. A significant genetic correlation between body color and body size was found in recombinant inbred lines derived from hybrids of brown and black morph strains.Conclusions:The restricted distribution of D. gunungcola in Southern hemisphere coincides with the lack of highland habitat near the equator. Four plant species were found to be exclusively utilized by D. elegans only in Taiwan whereas the same flower species are shared by both fly species in Java and Sumatra, suggesting the presence of inter-specific competition for breeding sites in overlapping zones. Darker body coloration with larger body size appears to have evolved twice in this lineage, reflecting similar patterns of natural selection in Indonesia and postglacial Taiwan.
Combinatory anti-tumor activities of AQ4 and temsirolimus against colorectal cancer cells
Authors: Okamoto Kazuaki , Nozawa Hiroaki , Sonoda Hirofumi , Kaneko Manabu , Ishihara Soichiro 
Published: August 2022

Abstract
Purpose: Banoxantrone is a topoisomerase II inhibitor that is selectively activated in hypoxia. Although it has exhibited anti-tumor activity against several types of cancers in preclinical models, its efficacy against colorectal cancer (CRC) remains unclear.Methods: We examined the antitumor effects of AQ4, an activated metabolite of banoxantrone, in CRC cell lines (HT-29, CaR-1) using in vitro experiments under normoxic and hypoxic conditions. The inhibition of cell growth was assessed using a proliferation assay. The induction of apoptosis and changes in the cell cycle were measured using flow cytometry. Signaling pathways involved in apoptosis and hypoxia were analyzed. The anti-tumor activity of temsirolimus, an inhibitor of mammalian target of rapamycin, and the combined effects of temsirolimus and AQ4 were also evaluated.Results: Regardless of the oxygen condition, a single drug treatment with AQ4 or temsirolimus inhibited proliferation and induced apoptosis in both cell lines, accompanied by a reduction in the phosphorylation of S6. AQ4 induced G2/M cell cycle arrest, whereas temsirolimus induced G0/G1 arrest. Moreover, the combined treatment markedly reduced the proportion of cells in the S phase and enhanced apoptosis, as evidenced by an increased Bax/Bcl-2 ratio. The hypoxia-induced activation of the HIF-1α pathway was suppressed by AQ4 and temsirolimus.Conclusion: Based on the cooperative anti-tumor activity of AQ4 and temsirolimus in vitro, the combination of banoxantrone plus temsirolimus has potential as a treatment option for CRC in preclinical and clinical settings.
Novel 3D Stochastic Modeling of Fracture Initiation and Propagation during Multiphase Fluid Flow in Fractured Media
Authors: Dulian  
Published: August 2022

Abstract
A complex concept of the propagation of fractures in carbonate or shale reservoirs means that their start and propagation during production are not given much consideration. A quantitative measurement of propagation in reservoir simulators is essential. Stochastic data, such as boundary conditions, pressure, viscosity, and other aiming functions, amplify this finding. The regime of multiphase flow further complicates but also challenges the question in terms of formulation. That is precisely the topic of this research, which is to say the crack network configurations as they propagate in time with random inputs, starting with stochastic optimum control. A known issue in fractured rocks is the Brinkman model, which contains parts where the Darcy flow predominates and areas where the Stokes flow predominate. Once we've developed our flow model in fractured rocks, we'll use energy minimization procedures to further refine it. Because of its robustness, our approach takes a little time to calculate. As this handicap is "reduced," it will be easier to put this model into practice at the Darcy scale in the future.