bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age Inclusive Compassion-Focused Therapy: a Pilot Group Evaluation
Authors: Altavilla Anna , Strudwick Anna 
Published: January 2022

AbstractThis study aimed to evaluate and provide recommendations to improve the effectiveness of an age inclusive compassion-focused therapy (CFT) group in secondary mental health services for participants experiencing a range of mental health difficulties. Of particular interest was the acceptability and impact of having a wide range of ages in such a group. The study employed a mixed method design. Validated self-report questionnaires were administered before and after the group intervention, and qualitative semi-structured interviews were conducted with six group participants. There was a significant increase in ratings on the Self-Compassion Scale (SCS) and Mindful Attention Awareness Scale (MAAS), a significant decrease in the depression subscale within the Depression and Anxiety Stress Scale (DASS) and a significant reduction in the risk subscale of the Clinical Outcome in Routine Evaluation (CORE). No significant differences were found on the overall scores and other subscales of the CORE and the DASS. Thematic analysis of the qualitative data identified four main themes: “Connection with others”, “Experience of a diverse age range”, “Group as a secure space” and “New strategies and tools”. This study provides preliminary evidence that an age inclusive CFT group is well received and has a beneficial impact for participants, with particular positivity gained through compassionately connecting with others. The range of ages was appreciated and appeared to have therapeutic benefits, although awareness of differing age-related needs is important. Limitations, recommendations for improvement and future research are discussed.
Public Procurement for the Circular Economy: a Comparative Study of Sweden and Spain
Authors: Fuertes Giné Leticia , Vanacore Emanuela , Hunka Agnieszka D. 
Published: January 2022

AbstractThis article examines the relationship between circular economy and public procurement by regarding green procurement as an enabler for the transition from sustainable to circular public procurement. Considering the different green procurement uptakes under the common legal framework of the European Union, and particularly, the contrasting practice results of Spain and Sweden and the opposed legal configuration of their procurement Acts, a comparative law study of the exclusion of suppliers, awarding criteria and special conditions of performance’s Articles is conducted.
Assessing the potential repercussions of the COVID-19 pandemic on global SDG attainment
Authors: Doi Hideyuki , Osawa Takeshi , Tsutsumida Narumasa 
Published: January 2022

AbstractThe coronavirus disease (COVID-19) pandemic has led to a worldwide lockdown, and this restriction on human movements and activities has significantly affected society and the environment. Some effects might be quantitative, but some might be qualitative, and some effects could prolong immediately and/or persistently. This study examined the consequences of global lockdown for human movement and nitrogen dioxide (NO2) emissions using an air pollution index and dataset and satellite image analyses. We also evaluated the immediate (during lockdown) and persistent (after lockdown) effects of lockdown on achieving the SDGs. Our analysis revealed a drastic reduction in human movement and NO2emissions and showed that many SDGs were influenced both immediately and persistently due to the global lockdown. We observed the immediate negative impacts on four goals and positive impacts on five goals, especially those concerning economic issues and ecosystem conservation, respectively. The persistent effects of lockdown were likely to be predominantly reversed from their immediate impacts due to economic recovery. The global lockdown has influenced the global community’s ability to meet the SDGs, and our analysis provides powerful insights into the status of the internationally agreed-upon SDGs both during and after the COVID-19-induced global lockdown.
Riboflavin-binding proteins for singlet oxygen production
Authors: Lafaye Céline , Aumonier Sylvain , Torra Joaquim , Signor Luca , von Stetten David , Noirclerc-Savoye Marjolaine , Shu Xiaokun , Ruiz-González Rubén , Gotthard Guillaume , Royant Antoine , Nonell Santi 
Published: January 2022

AbstractminiSOG, developed as the first fully genetically encoded singlet oxygen photosensitiser, has found various applications in cell imaging and functional studies. Yet, miniSOG has suboptimal properties, including a low yield of singlet oxygen generation, which can nevertheless be improved tenfold upon blue light irradiation. In a previous study, we showed that this improvement was due to the photolysis of the miniSOG chromophore, flavin mononucleotide (FMN), into lumichrome, with concomitant removal of the phosphoribityl tail, thereby improving oxygen access to the alloxazine ring. We thus reasoned that a chromophore with a shorter tail would readily improve the photosensitizing properties of miniSOG. In this work, we show that the replacement of FMN by riboflavin (RF), which lacks the bulky phosphate group, significantly improves the singlet oxygen quantum yield (ΦΔ). We then proceeded to mutagenize the residues stabilizing the phosphate group of FMN to alter the chromophore specificity. We identified miniSOG-R57Q as a flavoprotein that selectively binds RF in cellulo, with a modestly improved ΦΔ. Our results show that it is possible to modify the flavin specificity of a given flavoprotein, thus providing a new option to tune its photophysical properties, including those leading to photosensitization. We also determined the structure of miniSOG-Q103L, a mutant with a much increased ΦΔ, which allowed us to postulate the existence of another access channel to FMN for molecular oxygen.
Graphical abstract
Benefit-Cost Ratios of Continuing Routine Immunization During the COVID-19 Pandemic in Africa
Authors: Watts Elizabeth , Mak Joshua , Patenaude Bryan 
Published: January 2022

AbstractDisruptions in routine immunization caused by COVID-19 put African countries with large vaccine-preventable disease burdens at high risk of outbreaks. Abbas et al. (2020) showed that mortality reduction from resuming immunization outweighs excess mortality from COVID-19 caused by exposure during immunization activities. We leverage these estimates to calculate benefit-cost ratios (BCRs) of disrupted immunization and apply cost of illness (COI) and value of statistical life-year (VSLY) approaches to estimate the cost of excess child deaths from eight vaccine-preventable diseases. BCRs were computed for each country, vaccine, and Expanded Program on Immunization visit. Secondary estimates that include the cost of providing immunization are presented in scenario analysis. Suspended immunization may cost $4949 million due to excess mortality using the COI approach, or $34,344 million using the VSLY approach. Likewise, excess COVID-19 deaths caused by exposure from immunization activities would cost $53 and $275 million using the COI and VSLY approaches, respectively. BCRs of continuing routine immunization are 94:1 using COI and 125:1 using VSLY, indicating that the economic costs of suspending immunization exceed that of COVID-19 deaths risked by routine immunization. When including the costs of providing routine immunization during the COVID-19 pandemic, the BCRs are 38:1 and 97:1 using the COI and VSLY approaches, respectively.
Youth Sexuality, Responsibility, and the Opening of the Brook Advisory Centres in London and Birmingham in the 1960s
Authors: Rusterholz Caroline 
Published: January 2022

AbstractThis article takes the opening of the Brook Advisory Centres in London (1964) and Birmingham (1966) as a comparative case study for exploring the public debate on youth sexuality. The two centers were the first in postwar Britain specifically dedicated to the provision of advice on birth control and emotional problems to unmarried and young people. By focusing on an initiative that launched amid rising concerns over illegitimacy and promiscuity, the article engages with the debate over social change in the 1960s and the so-called permissive society. The author argues that the notion of responsibility became a key paradigm for supporters of a new sexual culture. Combining archival material, media analysis, and oral history interviews, the author shows that in constructing the need for a service for unmarried people, the Brook Advisory Centres faced accusations of encouraging promiscuity. Their main line of defense was the production of a narrative that stressed the notion of responsibility and moral guidance for unmarried people in avoiding unwanted babies. And in the debate around youth sexuality, locality mattered. In Birmingham, the prospect of formal contraceptive advice for unmarried girls was violently opposed by church members and family-planning doctors, whereas London witnessed the creation of a viable discourse with an emphasis on sexual responsibility.
Terrorist Attacks against Hospitals: World-Wide Trends and Attack Types
Authors: Ulmer Nitzan , Barten Dennis G. , De Cauwer Harald , Gaakeer Menno I. , Klokman Vincent W. , van der Lugt Monique , Mortelmans Luc J. , van Osch Frits H.M. , Tan Edward C.T.H. , Boin Arjen 
Published: January 2022

AbstractBackground:Analysts have warned on multiple occasions that hospitals are potential soft targets for terrorist attacks. Such attacks will have far-reaching consequences, including decreased accessibility, possible casualties, and fear among people. The extent, incidence, and characteristics of terrorist attacks against hospitals are unknown. Therefore, the objective of this study was to identify and to characterize terrorist attacks against hospitals reported to the Global Terrorism Database (GTD) over a 50-year period.Methods:The GTD was used to search for all terrorist attacks against hospitals from 1970-2019. Analyses were performed on temporal factors, location, attack and weapon type, and number of casualties or hostages. Chi-square tests were performed to evaluate trends over time and differences in attack types per world region.Results:In total, 454 terrorist attacks against hospitals were identified in 61 different countries. Of these, 78 attacks targeted a specific person within the hospital, about one-half (52.6%) involved medical personnel. There was an increasing trend in yearly number of attacks from 2008 onwards, with a peak in 2014 (n = 41) and 2015 (n = 41). With 179 incidents, the “Middle East & North Africa” was the most heavily hit region of the world, followed by “South Asia” with 125 attacks. Bombings and explosions were the most common attack type (n = 270), followed by 77 armed assaults. Overall, there were 2,746 people injured and 1,631 fatalities. In three incidents, hospitals were identified as secondary targets (deliberate follow-up attack on a hospital after a primary incident elsewhere).Conclusion:This analysis of the GTD identified 454 terrorist attacks against hospitals over a 50-year period. It demonstrates that the threat is real, especially in recent years and in world regions where terrorism is prevalent. The findings of this study may help to create or further improve contingency plans for a scenario wherein the hospital becomes a target of terrorism.
Secular trends in low birth weight and child undernutrition in West Africa: evidence from complex nationwide surveys, 1985–2019
Authors: Dwomoh Duah , Sewor Christian , Mohammed Seidu Awal , Annim Samuel , Stranges Saverio , Kandala Ngianga-Bakwin , Amegah A Kofi 
Published: January 2022

AbstractObjective:We present prevalence estimates and secular trends of stunting, wasting, underweight, and anaemia among children under 5 years of age and low birth weight (LBW) over the period 1985–2019 in West Africa (WA).Design:Analysis of Demographic and Health Survey (DHS) and World Bank data. DerSimonian–Laird random effect model with the Knapp–Hartung adjustment to the standard error was used to derive overall prevalence estimates. We used fixed effect ordinary least square regression models with cluster robust standard error to conduct time trends analyses.Setting:West Africa.Participants:Children aged 0 to 59 months.Results:Three distinct periods (1986–1990, 1993–1996 and 1997–2000) of sharp increases in prevalence of all outcomes was observed. After the year 2000, prevalence of all outcomes except LBW started to decline with some fluctuations. LBW prevalence showed a steady increase after 2000. We observed a decline in prevalence of stunting (β = –0·20 %; 95 % CI –0·43 %, 0·03 %), log-wasting (β = –0·02 %; 95 % CI –0·02 %, –0·01 %), log-underweight (β = –0·02 %; 95 % CI –0·03 %, –0·01 %) anaemia (β = –0·44; 95 % CI –0·55 %, –0·34 %), and an increase in LBW (β = 0·06 %; 95 % CI –0·10 %, 0·22 %) in WA over the period. Pooled prevalence of stunting, wasting, underweight, anaemia and LBW in WA for the period 1985–2019 was 26·1 %, 16·4 %, 22·7 %, 76·2 % and 11·3 %, respectively.Conclusions:Child undernutrition prevalence varied greatly between countries and the year cohorts. We observed marginal reductions in prevalence of all outcomes except anaemia where the reductions were quite striking and LBW where an increase was noted. There is the need for more rigorous and sustained targeted interventions in WA.
Status and Direction of Atom Probe Analysis of Frozen Liquids
Authors: Stender Patrick , Gault Baptiste , Schwarz Tim M , Woods Eric V , Kim Se-Ho , Ott Jonas , Stephenson Leigh T , Schmitz Guido , Freysoldt Christoph , Kästner Johannes , El-Zoka Ayman A 
Published: January 2022

Abstract
Imaging of liquids and cryogenic biological materials by electron microscopy has been recently enabled by innovative approaches for specimen preparation and the fast development of optimized instruments for cryo-enabled electron microscopy (cryo-EM). Yet, cryo-EM typically lacks advanced analytical capabilities, in particular for light elements. With the development of protocols for frozen wet specimen preparation, atom probe tomography (APT) could advantageously complement insights gained by cryo-EM. Here, we report on different approaches that have been recently proposed to enable the analysis of relatively large volumes of frozen liquids from either a flat substrate or the fractured surface of a wire. Both allowed for analyzing water ice layers which are several micrometers thick consisting of pure water, pure heavy water, and aqueous solutions. We discuss the merits of both approaches and prospects for further developments in this area. Preliminary results raise numerous questions, in part concerning the physics underpinning field evaporation. We discuss these aspects and lay out some of the challenges regarding the APT analysis of frozen liquids.
Seasonal Flux of Ice‐Related Organic Matter During Under‐Ice Blooms in the Western Arctic Ocean Revealed by Algal Lipid Biomarkers
Authors: Gal Jong‐Ku , Ha Sun‐Yong , Park Jisoo , Shin Kyung‐Hoon , Kim Dongseon , Kim Nan‐Young , Kang Sung‐Ho , Yang Eun Jin 
Published: January 2022

AbstractSatellite observations and modeling data have suggested a significant increase in net primary production in the Arctic Ocean over the last decade due to retreating sea ice and the development of light availability caused by Arctic warming. Subsequently, under‐ice blooms (UIBs) are being recognized as an important phenomenon from the traditional perspective. However, the role of sea‐ice algae in UIBs is still unknown due to the limited availability of continuous observations. We analyzed data on primary producer‐derived lipid biomarkers from sinking particles collected over 1 year using time‐series sediment traps on the East Siberian Sea and Chukchi Sea slopes. Based on the seasonal changes in sympagic organic carbon derived from the data of the ice proxy (IP25) flux and pelagic biomarkers, such as highly branched isoprenoid trienes, epi‐brassicasterol and dinosterol, a UIB was identified in summer 2018 on the East Siberian Sea slope. Compared to the nutrient distribution on the Chukchi Sea slope, the UIB on the East Siberian Sea slope might have been triggered by the nutrient supply. The estimated flux‐weighted mean sympagic organic carbon value measured during the UIB period (May−August) was 1.04 mg m−2 d−1 on the East Siberian Sea slope, approximately five times greater than recorded that on the Chukchi Sea slope (0.23 mg m−2 d−1) during the same period. Our findings suggest that the importance of sea‐ice algae as primary producers has increased as the UIB phenomenon has become more important in the Arctic Ocean and that sea‐ice environments face changes due to Arctic warming.
Global Distribution and Geological Context of Co‐Existing Occurrences of Olivine‐Rich and Plagioclase‐Rich Materials on the Lunar Surface
Authors: Yamamoto Satoru , Ohtake Makiko , Karouji Yuzuru , Kayama Masahiro , Nagaoka Hiroshi , Ishihara Yoshiaki , Haruyama Junichi 
Published: January 2022

AbstractWe examined the global distribution and geological context of lunar sites where olivine‐ and plagioclase‐rich materials co‐exist. These sites are areas showing plagioclase‐rich spectra adjacent to areas showing olivine‐rich spectra, and they extend over several hundreds of meters on the lunar surface. From an analysis of the high‐spatial‐resolution data obtained from the SELENE (Kaguya) multiband imager, we identified 14 co‐existing occurrences among 49 olivine‐rich sites located around large impact basins. We found that the co‐existing occurrences are limited to a few sites among the olivine‐rich sites in the Moscoviense, Crisium, and Imbrium basins, while six of seven olivine‐rich sites in the Schrödinger basin show co‐existing occurrence. The geological features between the co‐existing occurrences and the olivine‐rich sites without plagioclase‐rich materials showed no clear difference, but both types of site are found at fresh geological features located around the peak rings of impact basins. These results may suggest that the co‐existing occurrences are closely related to the material heterogeneity of the peak ring regions. The heterogeneity could be formed by mixing of the olivine‐rich mantle and the anorthosite‐rich crust during impact basin formation, or it might be a reflection of the compositional heterogeneity of the lunar lower crust. For future sample return missions, the detailed information on the co‐existing occurrences presented here might be useful for a sampling strategy to select a “one‐stop” site that provides important information for the overall characterization of lunar mantle and crustal materials.
Diagnosis of Model Errors With a Sliding Time‐Window Bayesian Analysis
Authors: Hsueh Han‐Fang , Guthke Anneli , Wöhling Thomas , Nowak Wolfgang 
Published: January 2022

AbstractDeterministic hydrological models with uncertain, but inferred‐to‐be‐time‐invariant parameters typically show time‐dependent model errors. Such errors can occur if a hydrological process is active in certain time periods in nature, but is not resolved by the model or by its input. Such missing processes could become visible during calibration as time‐dependent best‐fit values of model parameters. We propose a formal time‐windowed Bayesian analysis to diagnose this type of model error, formalizing the question “In which period of the calibration time‐series does the model statistically disqualify itself as quasi‐true?” Using Bayesian model evidence (BME) as model performance metric, we determine how much the data in time windows of the calibration time‐series support or refute the model. Then, we track BME over sliding time windows to obtain a dynamic, time‐windowed BME (tBME) and search for sudden decreases that indicate an onset of model error. tBME also allows us to perform a formal, sliding likelihood‐ratio test of the model against the data. Our proposed approach is designed to detect error occurrence on various temporal scales, which is especially useful in hydrological modeling. We illustrate this by applying our proposed method to soil moisture modeling. We test tBME as model error indicator on several synthetic and real‐world test cases that we designed to vary in error sources (structure and input) and error time scales. Results prove the successful detection errors in dynamic models. Moreover, the time sequence of posterior parameter distributions helps to investigate the reasons for model error and provide guidance for model improvement.
Cancer-derived exosomal HSPC111 promotes colorectal cancer liver metastasis by reprogramming lipid metabolism in cancer-associated fibroblasts
Authors: Zhang Chong , Wang Xiang-Yu , Zhang Peng , He Tao-Chen , Han Jia-Hao , Zhang Rui , Lin Jing , Fan Jie , Lu Lu , Zhu Wen-Wei , Jia Hu-Liang , Zhang Ju-Bo , Chen Jin-Hong 
Published: January 2022

AbstractTumor metastasis is a hallmark of cancer. The communication between cancer-derived exosomes and stroma plays an irreplaceable role in facilitating pre-metastatic niche formation and cancer metastasis. However, the mechanisms underlying exosome-mediated pre-metastatic niche formation during colorectal cancer (CRC) liver metastasis remain incompletely understood. Here we identified HSPC111 was the leading upregulated gene in hepatic stellate cells (HSCs) incubated with CRC cell-derived exosomes. In xenograft mouse model, CRC cell-derived exosomal HSPC111 facilitated pre-metastatic niche formation and CRC liver metastases (CRLM). Consistently, CRC patients with liver metastasis had higher level of HSPC111 in serum exosomes, primary tumors and cancer-associated fibroblasts (CAFs) in liver metastasis than those without. Mechanistically, HSPC111 altered lipid metabolism of CAFs by phosphorylating ATP-citrate lyase (ACLY), which upregulated the level of acetyl-CoA. The accumulation of acetyl-CoA further promoted CXCL5 expression and secretion by increasing H3K27 acetylation in CAFs. Moreover, CXCL5-CXCR2 axis reinforced exosomal HSPC111 excretion from CRC cells and promoted liver metastasis. These results uncovered that CRC cell-derived exosomal HSPC111 promotes pre-metastatic niche formation and CRLM via reprogramming lipid metabolism in CAFs, and implicate HSPC111 may be a potential therapeutic target for preventing CRLM.
Truncated PARP1 mediates ADP-ribosylation of RNA polymerase III for apoptosis
Authors: Chen Qian , Ma Kai , Liu Xiuhua , Chen Shih-Hsun , Li Peng , Yu Yonghao , Leung Anthony K. L. , Yu Xiaochun 
Published: January 2022

AbstractCaspase-mediated cleavage of PARP1 is a surrogate marker for apoptosis. However, the biological significance of PARP1 cleavage during apoptosis is still unclear. Here, using unbiased protein affinity purification, we show that truncated PARP1 (tPARP1) recognizes the RNA polymerase III (Pol III) complex in the cytosol. tPARP1 mono-ADP-ribosylates RNA Pol III in vitro and mediates ADP-ribosylation of RNA Pol III during poly(dA-dT)-stimulated apoptosis in cells. tPARP1-mediated activation of RNA Pol III facilitates IFN-β production and apoptosis. In contrast, suppression of PARP1 or expressing the non-cleavable form of PARP1 impairs these molecular events. Taken together, these studies reveal a novel biological role of tPARP1 during cytosolic DNA-induced apoptosis.