bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of periodontitis, missing teeth, and oral hygiene behaviors with the incidence of hypertension in middle‐aged and older adults in Korea: A 10‐year follow‐up study
Authors: Hwang Su‐Yeon , Oh Hannah , Rhee Moo‐Yong , Kang Sangwook , Kim Hae‐Young 
Published: April 2022

AbstractBackgroundThe relationship between periodontitis and hypertension remains controversial. This study aimed to investigate the association of periodontitis, missing teeth, and oral hygiene behaviors with the incidence of hypertension.MethodsA total of 104,349 participants were selected from the National Health Insurance System‐Health Screening (NHIS‐HEALS) cohort. Incident hypertension and periodontitis were diagnosed based on the patients’ clinical records and health examinations. A multivariable Cox proportional hazards regression analysis was performed after adjusting for socioeconomic factors, coexisting disease, and health behaviors.ResultsThe mean age of the participants was 51.1 years (range, 40–79 years) at baseline, and 55.1% were men. A total of 52,855 incident hypertension cases were identified during the median follow‐up period of 9.6 years. Among the participants, periodontitis (hazard ratio [HR]: 1.02; 95% confidence interval [95% CI]: 1.00–1.04), number of missing teeth (for ≥15 group, HR: 1.40; 95% CI: 1.29–1.52), dental scaling (HR: 0.93; 95% CI: 0.91–0.95), and toothbrushing frequency (for ≥3 group, HR: 0.85; 95% CI: 0.83–0.88) were significantly associated with incident hypertension after full adjustments for covariates. While periodontitis was significantly associated with incident hypertension (HR: 1.04; 95% CI: 1.02–1.06) in the middle‐aged group (40–64 years), the effect was insignificant in the older group (≥65 years).ConclusionsOral inflammation could contribute to the incidence of hypertension; thus, efforts to reduce oral inflammation should be encouraged. Future intervention studies are warranted to determine whether oral health care could be beneficial in the management of hypertension.
Use of hydroxypropyl β‐cyclodextrin hybrid monolithic material as adsorbent for dispersive solid‐phase extraction of fluoroquinolones from environmental water samples
Authors: Zhou Li , Yu Jia 
Published: April 2022

In this study, the hydroxypropyl β‐cyclodextrin hybrid monolithic material was fabricated and firstly applied as an adsorbent for dispersive solid‐phase extraction coupled with high‐performance liquid chromatography to detect trace‐level seven fluoroquinolones in water samples. The prepared hydroxypropyl β‐cyclodextrin hybrid monolithic material was characterized by Fourier‐transform infrared spectroscopy, scanning electron microscopy, and adsorption experiments, which showed excellent specific adsorption to the target fluoroquinolones. Under the optimized conditions, the extraction methodology showed satisfactory precision with relative standard deviations between 2.6% and 5.6%, good linearity (R2 ≥ 0.9990), and satisfactory recoveries (82.5–91.8%). The limits of detection and limits of quantification of the method were in the range of 0.4–1.2 and 1.4–4.0 ng/mL, respectively, which confirmed the possibility of quantifying trace levels. Furthermore, the material could be reused at least five times. These results demonstrated that the hydroxypropyl β‐cyclodextrin hybrid monolithic material was a promising adsorbent for fluoroquinolones, and the established method combined dispersive solid‐phase extraction with high‐performance liquid chromatography was suitable for the determination of fluoroquinolones in aqueous samples.
Evaluation of Fetal Cardiac Function in Maternal Gestational Diabetes Mellitus by Speckle‐Tracking Echocardiography
Authors: Huang Peina , Deng Youbin , Feng Ling , Gao Yiping , Cheng Xueqing , Liu Hongyun 
Published: April 2022

ObjectivesGestational diabetes mellitus (GDM) is the most common metabolic disease that occurs during pregnancy and may result in fetal cardiac dysfunction. Our study aimed to assess the cardiac function in fetuses of mothers with GDM by a quantitative analysis software based on speckle‐tracking echocardiography.MethodsForty‐nine fetuses exposed to GDM and 50 normal fetuses were enrolled, and fetal echocardiography were performed and analyzed in this prospective cross‐sectional study. We compared cardiac systolic function between the two groups using fetal cardiac quantitative analysis software.ResultsIn the GDM group, left ventricular (24 ± 4 versus 28 ± 4, P < .001) and right ventricular global longitudinal strain (23 ± 4 versus 26 ± 4, P = .002) and right ventricular free wall strain (26 ± 6 versus 29 ± 5, P = .006) were significantly lower compared with the control group, whereas there was no significant difference in global spherical index (1.2 ± 0.1 versus 1.2 ± 0.1, P = .425). Additionally, 24‐segment transverse fraction shortening of the right ventricle was more impaired than the left, and the segments with reduced fraction shortening were mainly located in the mid and apical sections of the right ventricle, and midsection of the left ventricle.ConclusionFetuses exposed to GDM may have cardiac dysfunction before the onset of cardiac morphologic abnormalities, and the right ventricle is more vulnerable than the left during fetal development.
Medical and Surgical Treatment for Medication‐Induced Tremor: Case Report and Systematic Review
Authors: Amerika Wardell E. , van der Gaag Saskia , Mosch Arne , van der Gaag Niels A. , Hoffmann Carel F.E. , Zutt Rodi , Marinus Johan , Contarino Maria Fiorella 
Published: April 2022

ABSTRACTObjectiveTo present a case of refractory medication‐induced tremor successfully treated with deep brain stimulation (DBS) of the thalamic ventral intermediate nucleus (Vim) and to propose a medical and surgical treatment algorithm based on a systematical review of the literature.MethodsPatient data were retrospectively collected. A systematic search was performed in PubMed, Embase, and Cochrane Library. Subjective and objective data were pooled for analysis by classifying them into 5 predefined categories(no, minimal, moderate, good, and excellent effects).ResultsThe patient presented with lithium‐induced bilateral progressive hand tremor lasting 25 years. After DBS, he reported excellent tremor suppression until the last follow‐up (36 months after Vim‐DBS). For the review, 34 of 140 studies were included and evaluated (178 unique subjects, 31 different treatments). A good‐to‐excellent tremor suppression (50%–100%) in at least 50% of subjects was achieved using propranolol (12 studies, 50% of 56 subjects), tetrabenazine (5 studies, 51% of 13 subjects), and metoprolol (4 studies, 75% of 8 subjects). The effect of benztropine and diphenhydramine was none or only minimal to moderate (up to 50% improvement; both: 3 studies, 50% of 4 patients). One article reported minimal‐to‐moderate effectiveness after DBS of the ventral oral posterior nucleus of the thalamus. Methods were highly heterogeneous. All studies scored grade III or IV quality of evidence, which was insufficient for recommendations (level U).ConclusionTreatment decision making should be performed on a case‐by‐case basis considering the low level of evidence, and we propose a practically oriented treatment algorithm. Propranolol, tetrabenazine, and metoprolol might be effective. For selected and refractory cases, DBS might be considered.
The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy
Authors: Wenning Gregor K. , Stankovic Iva , Vignatelli Luca , Fanciulli Alessandra , Calandra‐Buonaura Giovanna , Seppi Klaus , Palma Jose‐Alberto , Meissner Wassilios G. , Krismer Florian , Berg Daniela , Cortelli Pietro , Freeman Roy , Halliday Glenda , Höglinger Günter , Lang Anthony , Ling Helen , Litvan Irene , Low Phillip , Miki Yasuo , Panicker Jalesh , Pellecchia Maria Teresa , Quinn Niall , Sakakibara Ryuji , Stamelou Maria , Tolosa Eduardo , Tsuji Shoji , Warner Tom , Poewe Werner , Kaufmann Horacio 
Published: April 2022

ABSTRACTBackgroundThe second consensus criteria for the diagnosis of multiple system atrophy (MSA) are widely recognized as the reference standard for clinical research, but lack sensitivity to diagnose the disease at early stages.ObjectiveTo develop novel Movement Disorder Society (MDS) criteria for MSA diagnosis using an evidence‐based and consensus‐based methodology.MethodsWe identified shortcomings of the second consensus criteria for MSA diagnosis and conducted a systematic literature review to answer predefined questions on clinical presentation and diagnostic tools relevant for MSA diagnosis. The criteria were developed and later optimized using two Delphi rounds within the MSA Criteria Revision Task Force, a survey for MDS membership, and a virtual Consensus Conference.ResultsThe criteria for neuropathologically established MSA remain unchanged. For a clinical MSA diagnosis a new category of clinically established MSA is introduced, aiming for maximum specificity with acceptable sensitivity. A category of clinically probable MSA is defined to enhance sensitivity while maintaining specificity. A research category of possible prodromal MSA is designed to capture patients in the earliest stages when symptoms and signs are present, but do not meet the threshold for clinically established or clinically probable MSA. Brain magnetic resonance imaging markers suggestive of MSA are required for the diagnosis of clinically established MSA. The number of research biomarkers that support all clinical diagnostic categories will likely grow.ConclusionsThis set of MDS MSA diagnostic criteria aims at improving the diagnostic accuracy, particularly in early disease stages. It requires validation in a prospective clinical and a clinicopathological study. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
A broadband circularly polarized e‐shaped patch antenna
Authors: Han Zhu‐Bin , Li Jian‐ying , Li Zhi‐Ying , Qi Yang‐Xiao , Li Dong 
Published: April 2022

AbstractWe proposed a broadband e‐shaped circularly polarized (CP) patch antenna with single‐point feed, and the feed point is located at the center of the antenna. The structure of this new antenna includes a ground plate and an e‐shaped patch placed on a substrate. The measured impedance bandwidth of the proposed antenna is approximately 17.89% (3.47–4.15 GHz), and the measured 3‐dB axial ratio bandwidth (ARBW) is about 9.47% (3.63–3.99 GHz). The antenna can achieve the gain of 8.4 to 8.7 dBi within the ARBW. And at the center frequency (3.8 GHz), right‐hand CP to left‐hand CP isolation of the antenna can reach −33 dB.
A low‐cost greenhouse‐based high‐throughput phenotyping platform for genetic studies: A case study in maize under inoculation with plant growth‐promoting bacteria
Authors: Yassue Rafael Massahiro , Galli Giovanni , Borsato Ronaldo , Cheng Hao , Morota Gota , Fritsche‐Neto Roberto 
Published: April 2022

AbstractGreenhouse‐based high‐throughput phenotyping (HTP) presents a useful approach for studying novel plant growth‐promoting bacteria (PGPB). Despite the potential of this approach to leverage genetic variability for breeding new maize (Zea Mays L.) cultivars exhibiting highly stable symbiosis with PGPB, greenhouse‐based HTP platforms are not yet widely used because they are highly expensive; hence, it is challenging to perform HTP studies under a limited budget. In this study, we built a low‐cost greenhouse‐based HTP platform to collect growth‐related image‐derived phenotypes. We assessed 360 inbred maize lines with or without PGPB inoculation under nitrogen‐limited conditions. Plant height, canopy coverage, and canopy volume obtained from photogrammetry were evaluated five times during early maize development. A plant biomass index was constructed as a function of plant height and canopy coverage. Inoculation with PGPB promoted plant growth in early developmental stages. Phenotypic correlations between the image‐derived phenotypes and manual measurements were at least 0.47 in the later stages of plant development. The genomic heritability estimates of the image‐derived phenotypes ranged from 0.23 to 0.54. Moderate‐to‐strong genomic correlations between the plant biomass index and shoot dry mass (0.24–0.47) and between HTP‐based plant height and manually measured plant height (0.55–0.68) across the developmental stages showed the utility of our HTP platform. Collectively, our results demonstrate the usefulness of the low‐cost HTP platform for large‐scale genetic and management studies to capture plant growth.
Assessment of porphyrogenicity of drugs and chemicals in selected hepatic cell culture models through a fluorescence‐based screening assay
Authors: Ma Christopher D. , Van Horn Cynthia G. , Wan Meimei , Bishop Colin , Bonkovsky Herbert L. 
Published: April 2022

AbstractCompounds that induce 5‐aminolevulinic acid [ALA] synthase‐1 and/or cytochromes P‐450 may induce acute porphyric attacks in patients with the acute hepatic porphyrias [AHPs]. Currently, there is no simple, robust model used to assess and predict the porphyrogenicity of drugs and chemicals. Our aim was to develop a fluorescence‐based in vitro assay for this purpose. We studied four different hepatic cell culture models: HepG2 cells, LMH cells, 3D HepG2 organoids, and 3D organoids of primary liver cells from people without known disease [normal human controls]. We took advantage of the fluorescent properties of protoporphyrin IX [PP], the last intermediate of the heme biosynthesis pathway, performing fluorescence spectrometry to measure the intensity of fluorescence emitted by these cells treated with selected compounds of importance to patients with AHPs. Among the four cell culture models, the LMH cells produced the highest fluorescence readings, suggesting that these cells retain more robust heme biosynthesis enzymes or that the other cell models may have lost their inducibility of ALA synthase‐1 [ALAS‐1]. Allyl isopropyl acetamide [AIA], a known potent porphyrogen and inducer of ALAS‐1, was used as a positive control to help predict porphyrogenicity for tested compounds. Among the tested compounds (acetaminophen, acetylsalicylic acid, β‐estradiol, hydroxychloroquine sulfate, alpha‐methyldopa, D (‐) norgestrel, phenobarbital, phenytoin, sulfamethoxazole, sulfisoxazole, sodium valproate, and valsartan), concentrations greater than 0.314 mM for norgestrel, phenobarbital, phenytoin, and sodium valproate produced fluorescence readings higher than the reading produced by the positive AIA control. Porphyrin accumulation was also measured by HPLC to confirm the validity of the assay. We conclude that LMH cell cultures in multi‐well plates are an inexpensive, robust, and simple system to predict the porphyrogenicity of existing or novel compounds that may exacerbate the AHPs.
Model‐informed drug development of voxelotor in sickle cell disease: Population pharmacokinetics in whole blood and plasma
Authors: Savic Radojka M. , Green Michelle L. , Jorga Karin , Zager Michael , Washington Carla B. 
Published: April 2022

AbstractOxbryta (voxelotor) is a small‐molecule inhibitor of sickle hemoglobin (Hb) polymerization approved for patients with sickle cell disease (SCD) aged greater than or equal to 12 years at a dose of 1500 mg once daily (q.d.). Voxelotor binds preferentially to Hb, and voxelotor partitioning into red blood cells is an effective predictor of Hb occupancy. The objectives of these analyses were to develop a population pharmacokinetic (PopPK) model for voxelotor in both plasma and whole blood in adults and adolescents to support the dose selection for optimal target engagement and to identify covariates that have a significant effect on voxelotor pharmacokinetics (PK) in plasma and whole blood. An integrated plasma and whole blood PopPK model with two compartments, first‐order absorption and elimination, and a site‐of‐action effect compartment adequately described the concentration‐time profiles of voxelotor in plasma and whole blood in patients treated up to 72 weeks. Covariates with significant effects on voxelotor PK included baseline blood volume on apparent volume of the central compartment and time‐varying hematocrit and dose on whole blood partitioning, indicating that clinical markers of voxelotor effect can, in turn, influence its PK. Furthermore, the model confirmed that voxelotor PK in plasma and whole blood is linear with dose and time and comparable for adults and adolescents. No clinically important covariate effects on voxelotor PK that warranted dose adjustment were identified in this analysis. Overall, the PopPK analyses contributed significantly to the voxelotor label and support 1500 mg q.d. as the therapeutic dose in adults and adolescents with SCD.
Prediction of CYP‐mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator
Authors: Kilford Peter J. , Chen Kuan‐Fu , Crewe Kim , Gardner Iain , Hatley Oliver , Ke Alice Ban , Neuhoff Sibylle , Zhang Mian , Rowland Yeo Karen 
Published: April 2022

AbstractPhysiologically‐based pharmacokinetic (PBPK) modeling is being increasingly used in drug development to avoid unnecessary clinical drug–drug interaction (DDI) studies and inform drug labels. Thus, regulatory agencies are recommending, or indeed requesting, more rigorous demonstration of the prediction accuracy of PBPK platforms in the area of their intended use. We describe a framework for qualification of the Simcyp Simulator with respect to competitive and mechanism‐based inhibition (MBI) of CYP1A2, CYP2D6, CYP2C8, CYP2C9, CYP2C19, and CYP3A4/5. Initially, a DDI matrix, consisting of a range of weak, moderate, and strong inhibitors and substrates with varying fraction metabolized by specific CYP enzymes that were susceptible to different degrees of inhibition, were identified. Simulations were run with 123 clinical DDI studies involving competitive inhibition and 78 clinical DDI studies involving MBI. For competitive inhibition, the overall prediction accuracy was good with an average fold error (AFE) of 0.91 and 0.92 for changes in the maximum plasma concentration (Cmax) and area under the plasma concentration (AUC) time profile, respectively, as a consequence of the DDI. For MBI, an AFE of 1.03 was determined for both Cmax and AUC. The prediction accuracy was generally comparable across all CYP enzymes, irrespective of the isozyme and mechanism of inhibition. These findings provide confidence in application of the Simcyp Simulator (V19 R1) for assessment of the DDI potential of drugs in development either as inhibitors or victim drugs of CYP‐mediated interactions. The approach described herein and the identified DDI matrix can be used to qualify subsequent versions of the platform.
Dual autoimmune diseases: Rheumatoid arthritis with systemic lupus erythematosus and Type 1 diabetes mellitus with multiple sclerosis
Authors: Ahmad Rizwan , Ahsan Haseeb 
Published: April 2022

AbstractAutoantibodies and inflammation are the hallmarks of autoimmune diseases (ADs). Organ‐specific and nonorgan‐specific ADs are divided according to whether the autoimmune reaction is directed against a specific tissue (e.g., thyroid in Hashimoto's thyroiditis) or widely expressed antigens (e.g., cell nuclei in systemic lupus erythematosus [SLE]). SLE is distinguished by the presence of circulating autoantibodies and immune complex deposition, both of which can induce inflammatory damage to many organs. Rheumatoid arthritis (RA), sometimes called inflammatory arthritis, is a systemic AD that affects the joints and causes synovitis. Multiple sclerosis (MS) is a central nervous system inflammatory disease with various neurological and autoimmune symptoms. Links have been reported between RA and SLE as well as between Type 1 diabetes mellitus and MS. Identification of shared genes and biological processes could aid in the discovery of possible treatment targets in these dual ADs. This review article explores the molecular nature and familial inheritance of dual ADs.
Construction of boric acid‐functionalized metal–organic frameworks for glycopeptide recognition in the serum of cervical cancer patients
Authors: Rao Dongping , Wang Baichun , Zhong Huizhen , Yan Yinghua , Ding Chuan‐Fan 
Published: April 2022

RationaleCervical cancer is one of the most common malignant tumors in women, and it is essential to explore potential biomarkers such as glycopeptides closely related to cancer in physiological samples of cervical cancer patients. Sample pretreatment is required before direct detection using mass spectrometry because there are certain limitations. Meanwhile, it is still highly desired to promote the functionalization and application of metal–organic framework (MOF)‐derived materials.MethodsUsing a post‐synthesis modification method, a novel type of boric acid‐functionalized MOF probe (designated as UiO‐66@PEI@Au@B(OH)2) is prepared for recognition of glycopeptides. The results are obtained using matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry and nano‐liquid chromarography–tandem mass spectrometry.ResultsThe UiO‐66@PEI@Au@B(OH)2 probe exhibits a low detection limit (0.6 fmol μL−1), an excellent recovery rate, comparatively good reusability and selectivity (HRP digests:BSA digests = 1:500). When UiO‐66@PEI@Au@B(OH)2 is used to selectively capture glycopeptides from the serum of a healthy person and a cervical cancer patient, 101 glycopeptides corresponding to 54 glycoproteins and 108 glycopeptides corresponding to 57 glycoproteins are detected, respectively.ConclusionsThe successful preparation of UiO‐66@PEI@Au@B(OH)2 provides a path for the investigation of the functionalization of MOF‐derived materials. The excellent performance of UiO‐66@PEI@Au@B(OH)2 not only demonstrates the huge potential of functionalized MOFs in the glycoproteome, but also opens up new phases of the application of MOF‐based materials.
Preoperative positioning planning for a robot‐assisted minimally invasive surgical system based on accuracy and safety
Authors: Su Peng , Li Jiang , Yue Chao , Liu Tian , Liu Baoguo , Li Jian 
Published: April 2022

AbstractBackgroundMinimally invasive robot‐assisted techniques are being used increasingly in surgical procedures, and the preoperative preparation for this kind of operation is more complicated than traditional operations.MethodTaking the placement requirements of minimally invasive thyroid surgery as the research object, taking the kinematic performance and safety of the manipulator as the optimization goal, a set of indexes and pendulums for evaluating the accuracy and safety of the manipulators are proposed accordingly.ResultsThe optimal preoperative positioning scheme is obtained based on Non dominated sorting genetic algorithm‐ II multi‐objective genetic algorithm. Meanwhile, compared with the optimization results of Gaot genetics and the positional scheme given by the surgeon based on experience, the advantages of the scheme are proved to be obvious.ConclusionThe scheme showed good performance in the comparison and proved the feasibility of the positional scheme in preoperative planning.