bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sars-Cov-2 B.1.1.529 (Omicron) variant outbreak: case series presentations and response to treatment at the Islamic University in Uganda health facility
Authors: Rashid Naziru 
Published: May 2022

The object of research: The study, investigated the clinical presentations of patients who tested Positive for Covid-19 (Omicron Variant), their response to treatment, and the levels of transmissibility of the infection.
Investigated problem: As the globe, continent, and nation are struggling with the emergency of the new COVID-19 omicron Virant outbreak there’s not much information known about the behavior of this new threat to enable clinicians, and public health specialists, and policymakers to curb the problem.
The main scientific results: The study found that headache, cough, fevers and, general body weakness was the commonest presenting complaints, 3 of the cases reported difficulties in breathing. None of the cases required admission. There was no difference in the severity of the illness and the response to treatment between the vaccinated and the non-vaccinated cases. Cases that did steaming as an adjuvant/supplementary treatment reported a shorter duration of symptomatic relief than those that did not.
The area of practical use of the research results: The findings will act as a practical guide to clinicians, public health specialists, and policymakers in the management of the COVID-19 Omicron Variant.
Innovative technological product: The use of steaming as an adjuvant to symptomatic relief management of respiratory tract infections.
Scope of the innovative technological product: Omicron Variant produces a less severe illness than earlier variants of COVID-19. The study also reveals that vaccination alone was not effective in the prevention of contraction of the Omicron Variant and other newer variants. However, vaccination may have been advantageous in protecting the cases from progressing to severe disease. Thus, other IPCs measures must be maintained and booster doses of COVID-19 vaccinations should be encouraged. Large-scale on the effectiveness of steaming and other locally made remedies for symptomatic management of respiratory tract infections should be done.
Glass as a State of Matter—The “newer” Glass Families from Organic, Metallic, Ionic to Non-silicate Oxide and Non-oxide Glasses
Authors: Möncke Doris , Topper Brian , Clare Alexis G. 
Published: May 2022

OVERVIEWIn theory, any molten material can form a glass when quenched fast enough. Most natural glasses are based on silicates and for thousands of years only alkali/alkaline earth silicate and lead-silicate glasses were prepared by humankind. After exploratory glass experiments by Lomonosov (18th ct) and Harcourt (19th ct), who introduced 20 more elements into glasses, it was Otto Schott who, in the years 1879–1881, melted his way through the periodic table of the elements so that Ernst Abbe could study all types of borate and phosphate glasses for their optical properties. This research also led to the development of the laboratory ware, low alkali borosilicate glasses. Today, not only can the glass former silicate be replaced, partially or fully, by other glass formers such as oxides of boron, phosphorous, tellurium or antimony, but also the oxygen anions can be substituted by fluorine or nitrogen. Chalcogens, the heavier ions in the group of oxygen in the periodic table (S, Se, Te), on their own or when paired with arsenic or germanium, can function as glass formers. Sulfate, nitrate, tungstate and acetate glasses lack the conventional anion and cation classification, as do metallic or organic glasses. The latter can occur naturally—amber predates anthropogenic glass manufacture by more than 200 million years.In this chapter, we are going to provide an overview of the different glass families, how the structure and properties of these different glass types differ from silicate glasses but also what similarities are dictated by the glassy state. Applications and technological aspects are discussed briefly for each glass family.
Editorial
Authors: De Castro Biane , Izoton Monique , Semensatto Simone 
Published: May 2022

A Revista Eletrônica Científica da Uergs (RevUergs), no caminho de seu reconhecimento pela comunidade científica, acaba de ser indexada às bases internacionais Directory of Open Access Journals (DOAJ) e Red Iberoamericana de Innovación y Conocimiento Científico (REDIB). Ser indexado em diretórios e plataformas internacionais como essas significa que o periódico atingiu altos níveis de qualidade de seus serviços e de serviços de publicação para autores e usuários. Para atingir esses níveis, foram necessárias algumas adaptações e mudanças no site e na versão final dos artigos. Em 2022, ano em que a Revista estará completando sete anos de existência, celebramos essas duas indexações e também as modificações no regulamento que institui a Revista Eletrônica da Universidade do Estado do Rio Grande do Sul. A Resolução Consun Nº 012/2015 foi revogada e substituída pela Resolução Conepe Nº 027/2021, que regulamenta a Revista Eletrônica Científica da Uergs, de 16 de dezembro de 2021. A nova resolução reflete a atual organização funcional, tanto da equipe editorial quanto das características da publicação. Também se encontra disponível na página da Revista a nova edição do manual do periódico, intitulado: “Orientações aos editores da Revista Eletrônica Científica da Uergs”.
Current Status and Challenges of Aptamers Screening and Optimization
Authors: Tan Yong , Ma Lan , Yang Xue , Cheng Qi-Ni , Wu Jiang-Feng 
Published: May 2022

Background:
Aptamers, consisting of single-stranded DNA or RNA, have secondary
and tertiary structures which could bind specifically to target molecules. They are characterized by
strong specificity, high affinity, low molecular weight, and low immunogenicity; therefore, the current
research focuses on their potential as a targeted drug carrier, a diagnostic probe for diseases, or
as a direct therapeutic drug.

Objective:
In this review, how to improve the success rate of adaptor screening and the optimization
after screening is described.

Results:
For aptamer screening, an efficient selection strategy is needed. In this article, by analyzing
key aspects of SELEX such as initial library design, screening procedures, truncation and modification
after screening, a comprehensive analysis of each step that might meet obstacles in
SELEX is provided.

ConclusioN:
Aptamers, which possess the specificity and affinity with the target, can serve as targeted
drug carriers or biosensors for diagnosing a disease. If the problems in the screening process
in cell-SELEX technology, truncation, and modification after screening are solved, it will have a
broader range of applications.
Anti-Tumor and Anti-Metastasis Effects of Berbamine-Loaded Lipid Nanoparticles
on Pancreatic Cancer
Authors: Tang Zhiyi , Niu Yichun , Xu Zhiyuan , Shi Yanmei , Liu Yaqiong , Fu Wen , Zheng Mengyao , He Haiyu , Wu Tao 
Published: May 2022

Objective:
The aim of the study was to investigate the therapeutic potential of Berbamine-loaded lipid nanoparticles
(BBM-NPs) in pancreatic cancer.

Methods:
Dopamine polymerization-polylactide-TPGS nanoparticles were synthesized to prepare BBM-NPs, and the
change in particle size of BBM-NPs was measured. Cell Counting Kit-8 (CCK8) assay, plate cloning experiment, and
apoptosis analysis were performed to evaluate the cytotoxicity of BBM-NPs against the pancreatic cancer cells
(PANC-1 and AsPC-1). Migration and invasion abilities of the tumor cells were determined by Transwell and wound
healing assays. The intracellular level of ROS and expression of tumor progression-related proteins were measured
using ROS-kit and western blot assay. Besides, an in vivo study was performed in the Balb/c nude mice to analyze the
function of BBM-NPs in tumor growth.

Results:
The in vitro studies showed that BBM-NPs with stable particle size and sustained drug release effectively
inhibited the viability, proliferation, migration, and invasion of pancreatic cancer cells, while promoting cell apoptosis.
Moreover, the in vivo experiments revealed that compared to Free BBM, BBM-NPs exhibited a stronger inhibitory
effect on the growth of xenograft tumors derived from PANC-1 cells in mice. In addition, increased expressions of
ROS, Bax, Cleaved Caspase-3, and γ-H2AX, as well as decreased expressions of MMP2, MMP9 and Bcl-2 were identified
in both Free BBM and BBM-NPs groups, while BBM-NPs exhibited a stronger effect on protein expression than
Free BBM.

Conclusion:
In summary, BBM-loaded lipid nanoparticles enhanced the therapeutic effects of BBM on pancreatic
cancer, providing a promising strategy for targeted cancer therapy.
Role of Collagen Regulators in Cancer Treatment: A Comprehensive Review
Authors: Angre Tanuja , Kumar Adarsh , Singh Ankit Kumar , Thareja Suresh , Kumar Pradeep 
Published: May 2022

Abstract:
Collagen is the most important structural protein and also the main component of the extra-cellular matrix
(ECM). It plays a role in tumor progression. Collagen can be regulated by altering its biosynthesis pathway through
various signaling pathways, receptors, and genes. The activity of cancer cells can also be regulated by other ECM
components like metalloproteinases, hyaluronic acid, fibronectin, and so on. Hypoxia is also one of the conditions that
lead to cancer progression by stimulating the expression of procollagen lysine as a collagen crosslinker, which increases
the size of collagen fibres promoting cancer spread. The collagen content in cancerous cells leads to resistance to
chemotherapy. So, to reduce this resistance, some collagen-regulating therapies are introduced, including inhibiting its
biosynthesis, disturbing cancer cell signaling pathway, mediating ECM components, and directly utilizing collagenase.
This study is an effort to compile the strategies reported to control the collagen level and different collagen inhibitors
reported so far. More research is needed in this area. Growing understanding of collagen’s structural features and its
role in cancer progression will aid in the advancement of newer chemotherapies.
Total Synthesis, Mechanism of Action, and Antitumor Efficacy of Camptothecin and
Some of its Analogues
Authors: Bacherikov Valeriy A. 
Published: May 2022

Abstract:
Over the past 55 years of research, various experimental methods have been developed for the total synthesis
of the anticancer camptothecin, a potent antitumor antibiotic, and its numerous active derivatives. The discoveries
made in synthetic pathways of the camptothecin heterocyclic core have contributed significantly to the theory and
strategy of directed organic synthesis aimed at finding effective anticancer drugs. The synthetic, medicinal chemistry
of camptothecin, the development of structures of anticancer camptothecin analogues, and the mechanism of their
activity in inhibiting the growth of different types of cancers, such as lung, ovarian, breast, pancreas, and stomach
cancers are analyzed. Various structural modifications in the A, B, C, D, and E-rings of the camptothecin molecule
have been thoroughly studied to improve bioavailability and diminish toxicity. Modern synthetic approaches to the
camptothecin analogues and several semi-synthetic methods are reviewed.
Native Iranian Medicinal Plants with Anti-Vaginal Infection Properties: A Systematic Review
Authors: Rashidipour Marzieh , Shakib Pegah , Goudarzi Gholamreza , Pournia Yadollah , Karimi Maryam , Sarlak Maryam 
Published: May 2022

Background:The use of herbs has recently been considered an effective method in the treatment of infections. The purpose of this study was to introduce Iranian medicinal plants with an effect on vaginal infections.Methods:In our systematic review study, keywords including ‘medicinal plants’, ‘Iranian medicinal plants’, ‘vaginal infection’, ‘essential oils’, and ‘extracts’ were searched in PubMed, Web of Science Direct, Scopus, Scientific Information Database, and Google Scholar. This study focused on the articles published from 2000 to 2019.Results and Discussion:According to our investigation, Stachys lavandulifolia, Thymus vulgaris L., Origanum vulgare L., Allium jesdianum, Cichorium intybus, Trigonella foenum-graecum, Azadirachta Indica, Stachys lavandulifolia, Coriandrum sativum L., Rosmarinus officinalis, Ferula gummosa L., Origanum syriacum, Eucalyptus globulus, Myrtus communis, Zingiber officinale, Punica granatum, Vitex agnus-castus, Mentha suaveolens, Quercus Brantii Lindl, Zataria multiflora, Berberis vulgaris, Thymus vulgaris L., Echinophora platyloba, Stachys lavandulifolia, Viola odorata, Menthe piperita, Eucalyptus camaldulensis, Ziziphus mauritiana, Quercus infectoria, Hypericum perforatum, Glycyrrhiza glabra L., Calendula officinalis, Origanum vulgare, Ziziphus nummularia, Satureja Bachtiarica, Foeniculum vulgare, Nigella sativa, Anethum graveolens, Salvia officinalis, and Calendula officinalis are used to treat vaginal infections.Conclusion:Therefore, native plants of Iran have been reported to have antimicrobial properties for the treatment of vaginal infections and can be used as a suitable and effective alternative to antibiotics in future research.
The Incredible Potential of Exosomes as Biomarkers in the Diagnosis of
Colorectal Cancer
Authors: Bhattacharya Sankha 
Published: May 2022

Abstract:
Colorectal cancer (CRC) is a common cancer that is one of the leading causes of cancer-related deaths around the world. The creation of new biomarkers for this disease is an important public health strategy for lowering the disease's mortality rate. According to new research, exosomes may be important sources of biomarkers in CRC. Exosomes are nanometer-sized membrane vesicles (30–200 nm) secreted by normal and cancer cells that transport RNA and proteins between cells and are thought to help with intercellular communication. Exosomes have been linked to CRC initiation and progression, and some differentially expressed RNAs and proteins in exosomes have been identified as potential cancer detection candidates. As a result, studying the relationship between exosomes and CRC may aid in the development of new biomarkers for the disease. This article discusses the importance of exosomes as biomarkers in the diagnosis of CRC, as well as their use in the treatment of CRC metastasis, chemoresistance, and recrudescence. We discuss the benefits and drawbacks of using exosomes as tumour markers, as well as the benefits and drawbacks of using exosomes as tumour markers.

Method:
The composites of the materials were synthesized using melt blending technique. The dielectric property of the produced materials were investigated using open ended coaxial probe technique. The dielectric constant values was used in the computational study of the composites using finite element method.

Conclusion:
From the electric field intensity, it was observed that the highest filler had the minimum transmitted intensity of 2185.87 v/m. Due to the high loss factor of 0.47 obtained for the 30 % filler content, waveguide terminators and other microwave components can be produced from this composite.
Factors Affecting The Performance of Furniture SMEs in Jepara
Authors: Prahastia Vinda Yuni , Ismanto Hadi 
Published: May 2022

AbstractThe furniture industry in Jepara is famous locally and worldwide. More than 31% of small and medium businesses in Jepara are furniture. Its reputation has attracted a lot of attention related to its role in economic activity. This study aims to analyze the factors affecting the financial performance of furniture SMEs. These factors include management strategy, financial resources, and customer relationships. The study was conducted on 126 respondents with proportional random sampling technique. Data collection using questionnaires and Likert scale, while data analysis was carried out using multiple linear regression analysis. The results showed that the three factors, namely management strategies, financial resources, and customer relationships had a partial effect on the performance of furniture SMEs. Financial management and management strategy planning will help SMEs achieve financial success. SME owners can develop their business by developing management strategies and maintaining good relationships with customers to be able to compete.Keywords: customer relations, SME performance, management strategy, financial resources, furnitureFaktor-faktor yang Mempengaruhi Kinerja UKM Furniture di JeparaAbstrakIndustri furniture di Jepara terkenal secara lokal dan di seluruh dunia. Lebih dari 31% bisnis kecil dan menengah di Jepara adalah furniture. Reputasinya telah menarik banyak perhatian terkait dengan perannya dalam kegiatan ekonomi. Penelitian ini bertujuan untuk menganalisis faktor-faktor yang mempengaruhi kinerja UKM furniture di Jepara. Faktor-faktor itu antara lain strategi manajemen, sumber keuangan, dan hubungan dengan pelanggan. Sebanyak 126 pengusaha furniture menjadi responden penelitian ini. Adapun teknik penentuan sampel yang digunakan adalah proportional random sampling. Pengumpulan data menggunakan kuesioner dengan menggunakan skala likert, sedangkan analisis data dilakukan dengan menggunakan analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa ketiga faktor, yaitu strategi manajemen, sumber keuangan, dan hubungan dengan pelanggan berpengaruh parsial terhadap kinerja UKM furniture. Pengelolaan keuangan dan perencanaan strategi manajemen akan membantu UKM mencapai keberhasilan keuangannya. Pemilik UKM dapat mengembangkan usahanya dengan menyusun strategi manajemen dan menjaga hubungan baik dengan pelanggan agar mampu bersaing. Kata kunci: hubungan dengan pelanggan, kinerja UKM, strategi manajemen, sumber keuangan, furniture
Strategic Plan for Survival of Shallot Farmers' Business Capital Management
Authors: Kamaludin Kamaludin , Wahyuningsih Sri 
Published: May 2022

AbstractThe objective of this research was to obtain a theoretical concept related to a strategic plan for business capital management for shallot farmers using rainfed lowland planting media. This research used a qualitative research method with the main focus of analyzing the management of the business capital of shallot farmers using rainfed rice-growing media. Data collection techniques used in this research were observation, interviews, and documentation using triangulation techniques to ensure the validity of the data obtained. The theory of strategic survival plan is the result and novelty of this research. The theory of strategic survival plan is the management of business capital where all the actions taken by shallot farmers using rainfed rice planting media try everything they can to obtain onion seeds as initial capital.Keywords: Business Capital Management, Shallot Farmers, Rainfed Rice Fields, Survival Strategic Plan.Rencana Strategis Bertahan pada Pengelolaan Modal Usaha Petani Bawang Merah AbstrakTujuan penelitian ini adalah untuk memperoleh sebuah konsep teori terkait rencana strategis pengelolaan modal usaha bagi petani bawang merah yang menggunakan media tanam sawah tadah hujan. Penelitian ini menggunakan metode penelitian kualitatif dengan fokus utama yaitu menganalisis tata kelola modal usaha petani bawang merah yang menggunakan media tanam sawah tadah hujan. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah dengan menggunakan observasi, wawancara, dan dokumentasi dengan menggunakan triangulasi teknik untuk memastikan validitas data yang diperoleh. Teori rencana strategis bertahan merupakan hasil dan kebaruan dalam penelitian ini. Teori rencana strategis bertahan adalah tata kelola modal usaha dimana segala tindakan yang dilakukan oleh petani bawang merah dengan menggunakan media tanam sawah tadah hujan berusaha dengan segala cara untuk dapat memperoleh bibit bawang sebagai modal awal. Kata kunci: Sawah Tadah Hujan, Petani Bawang Merah, Rencana Strategis Bertahan, Tata Kelola Modal Usaha
The Role of Work-Life Balance and Job Satisfaction as Predictors of Organizational Commitment
Authors: Yusnita Nancy , Gursida Hari , Herlina Erna 
Published: May 2022

AbstractMuch of the research on organizational commitment has generated findings that organizational commitment considers to predict individual performance. The purpose of the study is to examine the factors that affect organizational commitment, namely work-life balance and job satisfaction. The study was conducted at PT. PLN Indonesia, and mainly utilized quantitative data (from questionnaires). The sample for the study consisted of 210 permanent employees of PT. PLN. Path analysis was used to find out the relationship among variables. The results showed, there was a positive effect of job satisfaction on organizational commitment; a negative effect work-life balance on organizational commitment; a positive effect of work-life balance on job satisfaction; a positive effect of work-life balance on organizational commitment through job satisfaction. This study proposed some recommendations tostrong indicators that have a high contribution to the organizational commitment in order to improve employees' organizational commitment. Keywords: organizational commitment, job satisfaction, work-life balance, individual performancePeran Kesimbangan Pekerjaan – Kehidupan Pribadi dan Kepuasan Kerja sebagai Prediktor Komitmen terhadap Organisasi pada Perusahaan Publik AbstrakBanyak penelitian berkaitan dengan komitmen organisasi menunjukkan bahwa komitmen organisasi diyakini memprediksi kinerja individu. Tujuan dari penelitian ini adalah untuk mengkaji faktor-faktor yang mempengaruhi komitmen organisasi yaitu work-life balance dan kepuasan kerja. Penelitian dilakukan di PT. PLN Indonesia, dan menggunakan data kuantitatif (dari kuesioner). Sampel penelitian terdiri dari 210 karyawan tetap PT. PLN. Analisis jalur digunakan untuk mengetahui hubungan antar variabel. Hasil penelitian menunjukkan, terdapat pengaruh positif kepuasan kerja terhadap komitmen organisasi; pengaruh negatif work-life balance terhadap komitmen organisasi; pengaruh positif work-life balance terhadap kepuasan kerja; pengaruh positif work-life balance terhadap komitmen organisasi melalui kepuasan kerja. Penelitian ini mengusulkan beberapa rekomendasi indikator kuat yang memiliki kontribusi tinggi terhadap komitmen organisasi dalam rangka meningkatkan komitmen organisasi karyawan. Kata kunci: komitmen terhadap organisasi, kepuasan kerja, keseimbangan Pekerjaan-Kehidupan Pribadi, kinerja individu