bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammation‐Triggered Supramolecular Nanoplatform for Local Dynamic Dependent Imaging‐Guided Therapy of Rheumatoid Arthritis
Authors: Li Luoyuan , Wang Xuelong , Gao Rongyao , Zhang Bei , Liu Yuxin , Zhou Jing , Fu Limin , Wang Jian 
Published: January 2022

AbstractThe aging of population has resulted in a significant increase in the prevalence of rheumatoid arthritis (RA), which is a persistent and recurrent synovial inflammation caused by abnormal immune activation. Herein, the authors designed an inflammation‐triggered disassembly (ITD) nanoplatform by a supramolecular assembly method, which controls the decomposition and drug release through changes in cytokine concentrations and redox potentials during the onset of arthritis, and its dual‐targeted synergistic effect on collagen‐induced arthritis (CIA) rats resulted in higher cell death rate and immunosuppressive rate. Meanwhile, they propose the local dynamic dependent imaging (LDDI) technology to diagnose the disease status, which may produce corresponding changes with the fluctuation of inflammatory activity and improve the accuracy of dual‐target therapy by monitoring the synovial changes through in situ photoactivation of the second near infrared light (NIR‐II). Very importantly, histological analysis shows that ITD strategy relieved joint destruction and cartilage degeneration and its clinical score is similar to that of the healthy group. Their work provides an effective strategy for the early diagnosis and treatment of acute and chronic inflammation diseases, which can interfere to abnormal immune activation, rather than affecting the normal function of immune system.
Correlation between Transient Response and Neuromorphic Behavior in Organic Electrochemical Transistors
Authors: Yamamoto Shunsuke , Polyravas Anastasios G. , Han Sanggil , Malliaras George G. 
Published: January 2022

AbstractThe factors controlling the neuromorphic response of organic electrochemical transistors (OECTs) are examined. In these devices, the gate voltage is used to supply the pre‐synaptic input, while the drain current is taken as the post‐synaptic output. The behavior of devices made from polymer blends of a mixed conductor (PEDOT:PSS) and an ion conductor (PSSNa) is analyzed. The experimental results highlight that the post‐synaptic response timescale depends on the size of ion in the electrolyte. Modeling shows that the neuromorphic response is controlled by the transient response of the ionic circuit of the OECT. These insights on device response time pave the way for a more rational design of OECT‐based neuromorphic devices.
One‐pot Synthesis of 3‐Aryliden‐2,3‐dihydro‐4‐quinolones from o‐Anilinopropargyl Alcohols via Aldol Condensation of In Situ Generated 2,3‐Dihydroquinolin‐4‐ones and Aryl Aldehydes
Authors: Pan Wanyong , Zhai Jiulong , Yang Hong , Li Tiantian , Lu Xiaolei , Wang Zhihai , Yin Yan 
Published: January 2022

AbstractA one‐pot conversion of o‐anilinopropargyl alcohols to 3‐aryliden‐2,3‐dihydro‐4‐quinolone derivatives with 20 mol% TfOH as the catalyst has been devised. The method may proceed through a sequential Meyer‐Schuster rearrangement of o‐anilinopropargyls/intramolecular conjugated addition/aldol condensation of in situ generated 2,3‐dihydroquinolin‐4‐ones and aldehydes. Finally, the subsequent additions succeeded between 3‐benzyliden‐2,3‐dihydro‐4‐quinolones and hydrazines to give fused multicycles. The reaction is metal‐ and ligand‐free, proceeds under mild conditions, gives high yields, and has a broad substrate scope, making it a valuable method for the construction of 3‐aryliden‐2,3‐dihydro‐4‐quinolone functionalized building blocks.
Comparison of serum neurodegenerative biomarkers among hospitalized COVID‐19 patients versus non‐COVID subjects with normal cognition, mild cognitive impairment, or Alzheimer's dementia
Authors: Frontera Jennifer A. , Boutajangout Allal , Masurkar Arjun V. , Betensky Rebecca A. , Ge Yulin , Vedvyas Alok , Debure Ludovic , Moreira Andre , Lewis Ariane , Huang Joshua , Thawani Sujata , Balcer Laura , Galetta Steven , Wisniewski Thomas 
Published: January 2022

AbstractIntroductionNeurological complications among hospitalized COVID‐19 patients may be associated with elevated neurodegenerative biomarkers.MethodsAmong hospitalized COVID‐19 patients without a history of dementia (N = 251), we compared serum total tau (t‐tau), phosphorylated tau‐181 (p‐tau181), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), ubiquitin carboxy‐terminal hydrolase L1 (UCHL1), and amyloid beta (Aβ40,42) between patients with or without encephalopathy, in‐hospital death versus survival, and discharge home versus other dispositions. COVID‐19 patient biomarker levels were also compared to non‐COVID cognitively normal, mild cognitive impairment (MCI), and Alzheimer's disease (AD) dementia controls (N = 161).ResultsAdmission t‐tau, p‐tau181, GFAP, and NfL were significantly elevated in patients with encephalopathy and in those who died in‐hospital, while t‐tau, GFAP, and NfL were significantly lower in those discharged home. These markers correlated with severity of COVID illness. NfL, GFAP, and UCHL1 were higher in COVID patients than in non‐COVID controls with MCI or AD.DiscussionNeurodegenerative biomarkers were elevated to levels observed in AD dementia and associated with encephalopathy and worse outcomes among hospitalized COVID‐19 patients.
Nonequilibrium Charge Dynamics of Tomonaga–Luttinger Liquids in Quantum Hall Edge Channels
Authors: Fujisawa Toshimasa 
Published: January 2022

AbstractTomonaga–Luttinger liquids exhibit unique features that cannot be seen in ordinary Fermi liquids. Recent advancement in measurement techniques on 1D quantum Hall edge channels allows to reveal unique characteristics, such as spin‐charge separation and nonthermal metastable states. In this review, an overview of nonequilibrium dynamics in quantum‐Hall Tomonaga–Luttinger liquids is presented. After the introduction of a circuit model for collective excitations (bosons) in the system, transport eigenmodes in interaction‐ and disorder‐dominated regimes are discussed with time‐resolved charge measurements for the integer and fractional quantum Hall systems. Moreover, nonthermal steady states associated with the integrable model are studied with energy distribution functions obtained with a quantum dot spectrometer. These nontrivial dynamics can be extended to other 1D systems, including 2D topological insulators.
Shape Permanence in Diarylethene‐Functionalized Liquid‐Crystal Elastomers Facilitated by Thiol‐Anhydride Dynamic Chemistry
Authors: Hebner Tayler S. , Podgórski Maciej , Mavila Sudheendran , White Timothy J. , Bowman Christopher N. 
Published: January 2022

AbstractDiarylethene‐functionalized liquid‐crystalline elastomers (DAE‐LCEs) containing thiol‐anhydride bonds were prepared and shown to undergo reversible, reprogrammable photoinduced actuation. Upon exposure to UV light, a monodomain DAE‐LCE generated 5.5 % strain. This photogenerated strain was demonstrated to be optically reversible over five cycles of alternating UV/Visible light exposure with minimal photochrome fatigue. The incorporation of thiol‐anhydride dynamic bonds allowed for retention of actuated states. Further, re‐programming of the nematic director was achieved by heating above the temperature for bond exchange to occur (70 °C) yet below the nematic‐to‐isotropic transition temperature (100 °C) such that order was maintained between mesogens. The observed thermal stability of each of the diarylethene isomers of over 72 h allowed for decoupling of photo‐induced processes and polymer network effects, showing that both polymer relaxation and back‐isomerization of the diarylethene contributed to LCE relaxation over a period of 12 hours after actuation unless bond exchange occurred.
Synthesis of doxorubicin‐loaded PBMA‐b‐POEGMA micelles and assessment of its anticancer activity against breast cancer cells (4T1)
Authors: Gharnas‐Ghamesh Hamideh , Masoumi Mojtaba , Erfani‐Moghadam Vahid 
Published: January 2022

AbstractDoxorubicin (DOX) is a chemotherapy drug that possesses many side effects. This study aimed to synthesize PBMA‐b‐POEGMA [poly (butyl methacrylate)‐b‐poly (oligo ethylene glycol methacrylate)] diblock copolymer as a nanocarrier for loading of DOX, promoting anticancer efficacy of the drug, and decreasing its side effects. Hence, PBMA‐b‐POEGMA diblock copolymer was first synthesized by the RAFT method and then DOX encapsulated into the micellar nanocarrier. Self‐assembly behavior of copolymers and physicochemical/biological properties of nanocarriers were assessed. DLS and TEM images showed nanocarriers possessed spherical‐uniform structure with the mean size and polydispersity of 27 ± 1.34 nm and 0.13 ± 0.21 for blank‐micelles as well as, 45 ± 2.32 nm and 0.18 ± 0.18 for DOX‐loaded micelles, respectively. Synthesized micelles also provided high drug encapsulation efficiency (>80%) with a drug loading content of 4.53%. Moreover, the maximum released amount of drug was reported at 69%, with the Korsmeyer‐Peppas model, as a more suitable model to describe the release behavior of DOX from nanocarriers. Biologically, block copolymers were biocompatible against COS‐7 and 4T1 cell lines, in addition, free‐DOX showed higher cytotoxicity than DOX‐loaded micelles. Furthermore, 0.5 μg/mL concentration of drug‐loaded micelle led to growth inhibition of more than 60% of cancerous cells, during 48 h, so that higher level of cellular uptake of drug and apoptosis in 4T1 cells was induced by drug‐loaded micelles.
Übergangskonstruktionen aus UHPFRC für den Integralbrückenbau
Authors: Mayer Michael , Huß Michael , Kim Hoang Huy , Tue Nguyen Viet 
Published: January 2022

AbstractDank der Bereitstellung von normativen Regelungen für den Entwurf und die Bemessung nimmt die Anzahl von Integralbrücken weltweit deutlich zu, sowohl durch Neubauten als auch durch die nachträgliche Integralisierung von bestehenden Bauwerken. Neben vielen Vorteilen bezüglich des Fahrkomforts und der Lebenszykluskosten stellt sich die Wechselwirkung im Übergangsbereich zwischen Bauwerk und Straße bei Integralbrücken deutlich komplexer dar als bei gewöhnlichen Brücken, insbesondere bei langen Bauwerken. Breite Risse im bituminösen Fahrbahnbelag konnten deshalb in diesem Bereich häufig beobachtet werden. Diese Risse beeinflussen nicht nur den Fahrkomfort, sondern auch die Dauerhaftigkeit maßgeblich. Um die Bauwerksverformung auf viele feine Risse zu verteilen, wurde am Institut für Betonbau der TU Graz eine neue Übergangskonstruktion aus UHPFRC entwickelt. Diese neuartige Lösung wurde mittlerweile bereits bei zwei Integralbrücken in Österreich mit Überbaulängen von 90 m (Fehring) und 103 m (Trautenfels) eingesetzt. Die ersten Ergebnisse aus dem installierten Monitoringsystem beim Bauwerk in Fehring bestätigen die Funktionsweise der neuen Konstruktion eindrucksvoll.
Effects of pyruvate on primary metabolism and product quality for a high‐density perfusion process
Authors: Caso Stefania , Aeby Mathieu , Jordan Martin , Guillot Raphael , Bielser Jean‐Marc 
Published: January 2022

AbstractHigh volumetric productivities can be achieved when perfusion processes are operated at high cell densities. Yet it is fairly challenging to keep high cell density cultures in a steady state over an extended period. Aiming for robust processes, cultures were operated at a constant biomass specific perfusion rate (BSPR) in this study. The cell density was monitored with a capacitance probe and a continuous bleed maintained the targeted viable cell volume. Despite our tightly controlled BSPR, a gradual accumulation of ammonium and changes in cell diameter were observed during the production phase for three different monoclonal antibodies. Although a lot of efforts in media optimization have been made to reduce ammonium in fed‐batch process, less examples are known about how media components impact the cellular metabolism and thus the quality of monoclonal antibodies in continuous processes. In this study, we show that a continuous Na‐pyruvate feed (2 g/L/day) strongly reduced ammonium production and stabilized fucosylation, sialylation and high mannose content for three different mAbs.
Functionalized cryogel monoliths for fast and selective separation of nucleic acids directly from crude lysate
Authors: Shakya Akhilesh Kumar 
Published: January 2022

AbstractThe fast and selective separation of nucleic acids has been attractive recently because of their wide number of applications in the biomedical field such as the development of vaccines for infectious diseases, gene therapy, and diagnosis. Traditional approaches of nucleic acids separation are costlier, lengthy, and associated with possible denaturation because of the use of organic solvents in the elution step. Under this perspective, cryogels represent an attractive choice as a monolith stationary phase in column chromatography, which have proven efficient in recent chromatographic studies. Cryogels are the macroporous hydrogels with interconnecting properties between the pores. They allow the easy flow of large biomolecules with minimum mass transfer resistance. They are spongy in nature and possess good mechanical strength. Current article represents different developed functionalized cryogel monoliths for nucleic acids separation, their separation strategies, and challenges associated with further advancement in separation science.
LY395756 promotes NR2B expression via activation of AKT/CREB signaling in the juvenile methylazoxymethanol mice model of schizophrenia
Authors: Li Meng‐lin , Peng Yuan , An Ying , Li Guo‐yan , Lan Yue 
Published: January 2022

AbstractIntroductionSynaptic N‐methyl‐d‐aspartate receptor subtype 2B(NR2B) is significantly reduced in prefrontal cortex (PFC) in the neurodevelopmental methylazoxymethanol (MAM) model of schizophrenia (SCZ). Recent research has shown that LY395756 can effectively restore NR2B levels and improve cognitive performance in juvenile MAM mice model. However, the underlying mechanisms of these beneficial effects remain unclear.Materials and methodsJuvenile MAM mice model of SCZ is used in our study. Synaptic membrane protein levels were examined by western blotting under different treatment conditions. Interaction of cAMP‐response element binding protein (CREB) and the promoter of NR2B was detected by the chromatin immunoprecipitation (ChIP) assay. Further examination of signaling pathway that mediates NR2B expression was also investigated by western blotting.ResultsIn the PFC of the juvenile MAM mice schizophrenia model, CREB was found to directly bind with the promoter of NR2B. LY395756 activated the phosphorylation of AKT. Phosphorylated AKT subsequently induced the phosphorylation of CREB, and the activated CREB promoted the expression of NR2B. Subsequent experiments showed that the dephosphorylation of CREB induced by protein phosphatase 1 (PP1) can inhibit NR2B levels. Taken together, these findings support that the AKT/CREB signaling pathway is essential for the promoting effect of LY395756 on synaptic NR2B in PFC in juvenile MAM mice SCZ model.ConclusionsOur investigation has identified a novel mechanism by which LY395756 increases NR2B expression in juvenile MAM mice SCZ model. The AKT/CREB signaling pathway warrants further research as a potential direction for clinical treatment of SCZ.
A real‐world study of dacomitinib in later‐line settings for advanced non‐small cell lung cancer patients harboring EGFR mutations
Authors: Li Hong‐Shuai , Zhang Jin‐Yao , Yan Xiang , Xu Hai‐Yan , Hao Xue‐Zhi , Xing Pu‐Yuan , Wang Yan 
Published: January 2022

AbstractObjectiveDacomitinib has been approved for the first‐line treatment of non‐small cell lung cancer (NSCLC) carrying classical epidermal growth factor receptor (EGFR) mutations; however, real‐world data on its later‐line application are lacking.Materials and methodsPatients’ data were retrospectively collected from the Chinese National Cancer Center and the PLA hospital between August 2019 and August 2021. Kaplan‐Meier method and Log‐rank test were utilized to assess progression‐free survival (PFS) and overall survival (OS). Univariate and multivariate Cox regression analysis was conducted to determine prognostic indicators.ResultsIn total, 56 NSCLC patients harboring EGFR mutations treated with later‐line single dacomitinib or combinatory dacomitinib were enrolled. A total of 53 patients (94.6%) had treatment‐related adverse events; eight patients (14.3%) had grade 3 or 4 events. Among 49 evaluable patients, 26.5% (13 patients) had a confirmed partial response and 73.5% (36 patients) had disease control; the median duration of follow‐up was 9.6 months (95% confidence interval [CI], 8.4–10.8 months), the median progression‐free survival was 5.4 months (95% CI, 3.5–7.3 months), and the half‐year, 1‐year, and 2‐year OS rate were 79.2%, 70.6%, and 64.1%, respectively. Univariate analysis suggested that smoking, line of dacomitinib, and interval between last EGFR‐tyrosine kinase inhibitor (TKI) and dacomitinib were associated with PFS and OS; chemotherapy between last EGFR‐TKI and dacomitinib, and EGFR‐TKI generation followed by dacomitinib were respectively associated with PFS and OS; multivariate analysis indicated chemotherapy between last EGFR‐TKI and dacomitinib negatively affect PFS, and smoking and third‐generation EGFR‐TKI followed by dacomitinib negatively affect OS.ConclusionsThis real‐world study has shown that dacomitinib is active and well‐tolerated in NSCLC patients harboring different EGFR mutations in later‐line settings, even for those with brain metastases. Patients who benefited more from the first TKI were more likely to benefit from dacomitinib, and earlier application of dacomitinib after front‐line TKI resistance may be considered.
The clinicopathological and molecular characteristics of resected EGFR‐mutant lung adenocarcinoma
Authors: Zhou Wensheng , Liu Zhichao , Wang Yanan , Zhang Yanwei , Qian Fangfei , Lu Jun , Wang Huimin , Gu Ping , Hu Minjuan , Chen Ya , Yang Zhengyu , Zhao Ruiying , Lou Yuqing , Han Baohui , Zhang Wei 
Published: January 2022

AbstractBackgroundEpidermal growth factor receptor (EGFR) mutations were frequently found with concomitant genetic alterations in lung adenocarcinoma (LUAD). This study aimed to investigate the profile of concomitant alterations of EGFR‐mutant LUAD ≤3 cm in size and its prognostic effect on recurrence.MethodsFrom January 2018 to December 2018, patients with resected LUAD ≤3 cm in size in Shanghai Chest Hospital were identified. All patients underwent capture‐based targeted next‐generation sequencing (NGS) with a panel of 68 lung cancer‐related genes and were found with EGFR mutation. Clinicopathological and molecular characteristics and recurrence‐free survival (RFS) were analyzed.ResultsA total of 637 patients were enrolled in this study. The top three frequent co‐mutational genes were TP53 (179 of 637, 28.1%), PIK3CA (27 of 637, 4.2%), and ATM (22 of 637, 3.5%). The most common amplified genes were EGFR (37 of 637, 5.8%), followed by CDK4 (37 of 637, 5.8%) and MYC (12 of 637, 2.0%). Only TP53 mutation and EGFR amplification were adverse prognostic factors for RFS (all p < 0.001) in univariate analysis. Multivariable analysis further demonstrated that TP53 mutation and EGFR amplification were independent risk factors for RFS [(hazard ratio (HR) 2.07, 95% confidence interval (CI) 1.07–4.00, p = 0.030; HR 3.09, 95% CI 1.49–6.40, p = 0.002, respectively].ConclusionsConcomitant TP53 mutation and EGFR amplification were poor prognostic factors for RFS in patients with EGFR‐mutant resected LUAD. Our findings provide valuable understanding of the impact of concurrent alterations and implication for better implementation of precision therapy for patients.
Essential Oils of Six Achillea Species: Chemical Profiles, Antimicrobial Potential and Toxicity toward Crustaceans
Authors: Stojanović Jelena P. , Stojanović Gordana S. , Stojanović‐Radić Zorica Z. , Zlatković Bojan K. , Ickovski Jovana D. , Zlatanović Ivana G. , Jovanović Snežana Č. , Mitić Zorica S. 
Published: January 2022

AbstractThis is the first comparative study on antimicrobial activity of essential oils (EOs) of six Achillea species (A. crithmifolia, A. distans, A. grandifolia, A. millefolium, A. nobilis, and A. lingulata) against ATCC and clinical microbial strains isolated from human swabs and on their toxicological potential on crustaceans. Oxygenated monoterpenes represented the major compound class in all six EOs, ranging from around 50 % (A. millefolium, A. nobilis, and A. lingulata) up to over 80 % (A. crithmifolia and A. grandifolia). Specific phytochemical profiles of the major volatiles were determined for each species. Still, borneol was the dominant compound in EOs of three yarrow species: A. distans, A. lingulata, and A. millefolium. Other major compounds were 1,8‐cineole in A. crithmifolia, camphor in A. grandifolia, and artemisia ketone in A. nobilis EO. Antimicrobial activities of EOs were examined by a microdilution method revealing inhibitory action against all 15 studied strains in the range of 0.07–20.00 mg/mL (MICs). High toxicity (LC50 <100 μg/mL) in Artemia salina acute toxicity bioassay was a shared characteristic, appearing in five out of six tested EOs, i. e., those isolated from A. lingulata, A. millefolium, A. distans, A. nobilis, and A. grandifolia. In both types of biological tests, A. lingulata EO has shown the highest and A. crithmifolia EO the lowest potential. The strongest activities, recorded for EO of A. lingulata, which was the only studied species from the section Anthemoideae, may be explained by its somewhat unusual chemical composition. According to the obtained results, the second dominant compound of this EO is γ‐palmitolactone, which may be a significant agent regarding the antimicrobial activity and toxicity to crustaceans, either on its own or in union with other components, and it may be a suitable topic for further research.
Case report: Schizophrenia and hypertrophic osteoarthropathy, a rare syndrome hiding a life‐threatening condition
Authors: Baklouti Emna , Karoui Mehdi , Kammoun Rania , Ellouze Faten 
Published: January 2022

AbstractSchizophrenia is associated to somatic disorders especially cardio‐vascular and auto‐immune. Through this case report, we describe an association with hypertrophic osteoarthropathy (HPO). For this patient, it was a paraneoplastic syndrome secondary to lung cancer. This syndrome is rare but important to recognize since it could hide a life‐threatening condition.
Ordered Mesoporous Carbon‐supported Morphologically‐controlled Nano‐Gold: Role of Support as well as the Shape and Size of Gold Nanoparticles on the Selective Oxidation of Glycerol
Authors: Murthy Palle Ramana , Selvam Parasuraman 
Published: January 2022

AbstractGlyceric acid is one of the important intermediates of glycerol oxidation. However, it is extremely difficult to achieve high glyceric acid selectively as the reaction follows a complex pathway with the formation of a variety of undesired products. In this context, periodic mesoporous carbon‐supported gold catalysts show promise for selective formation of the targeted product. Therefore, in this investigation, an effort has made to study the effect of particle size and shape of a series of carbon supported with varied sized/shaped gold catalysts on the liquid‐phase oxidation of glycerol. Further, the role played by the surface of gold‐nanoparticles has prompted us to investigate in detail the isotropic (nanocube/nanosphere) and anisotropic (nanoslabs/nanorods) gold supported onto both activated/amorphous carbon (Au/AC) and ordered mesoporous carbon (Au/CMK‐3) towards glycerol oxidation. It was observed that the CMK‐3 supported gold nanocube exhibited the highest yield towards glyceric acid with an excellent stability in terms of recyclability/reusability.