bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismic vulnerability analysis of simply supported continuous bridge during construction
Authors: Xiong Huizhong , Jiang Shengtang , Huang Yong , Zhang Jian 
Published: June 2022

PurposeIn order to explore the damage probability of bridge engineering in the event of earthquake in the construction stages, the analysis method of seismic vulnerability in the construction stages is proposed in this paper.Design/methodology/approachBased on the joint simulation function of construction stage conditions and seismic response conditions of MIDAS/Civil finite element analysis software, combined with the method of IDA analysis and compared the relationship between demand and capacity.FindingsThe research shows that: (1) the average seismic loss in different construction stages varies greatly; (2) the seismic vulnerability varies greatly in different construction stages. The vulnerability of the bridge in stage 6 is determined by the longitudinal direction of bridge. Therefore, during the construction of the whole bridge, we should focus on strengthening the disaster and loss prevention strategy of earthquake insurance in the longitudinal direction of bridge. (3) The application of the secondary dead load mainly affects the fragilityin the longitudinal direction of bridge, but has little effect on the fragility in the transversal direction of bridge.Originality/valueThis paper is to explore the seismic vulnerability of a typical simply supported continuous bridge during the construction stages, and to trace the entire construction stage of a typical simply supported continuous bridge. According to the characteristics of the system transformation in the actual construction steps, demand-capacity ratios were established based on incremental dynamic analysis (IDA) and performance indicators of moment curvature and stability, and the seismic vulnerability research is carried out for the construction stages prone to earthquake damage. Furthermore, it provides a basis for seismic risk assessment of such bridges in different construction stages.
Determinants of adoption of IS-based service innovations in government to create public value
Authors: Duhamel Francois Bernard , Gutiérrez-Martínez Isis , Cordova-Díaz Hugo , Cue-Funes Sergio 
Published: June 2022

Purpose
This paper aims to propose a conceptual framework showing factors favoring the adoption of information systems (IS)-based service innovations in the public sector at the organizational level.

Design/methodology/approach
The research design is based on the development of a theoretical framework from the technology–organization–environment framework and from a case study of an outsourced IS-based electronic document management system from six different ministries in the same state in Mexico.

Findings
Strong contrasts in the degree of adoption of the service innovation appeared among various ministries involved in state government, revealing differences in the presence or absence of key variables, integrated into theoretical framework, including perception of external pressure; perception of benefits and risks and organizational readiness; and political, sociotechnical and economical inertia in given institutional conditions, leading to different public value outcomes associated with intraorganizational efficiencies and to the relationship between public administration and politicians.

Practical implications
Public managers must consider process mapping and sources of political, sociotechnical and economical inertia in given institutional conditions, to ensure a satisfactory adoption of service innovations in public administration and create public value. The promotion of a more structured and enduring professional career system in such context is another key to the adoption of innovations.

Originality/value
Based on theoretical and empirical grounds, the main contribution of this paper is to emphasize, through an integrated theoretical framework, the relatively unexplored roles of process mapping in organizational readiness and of political, sociotechnical and economic sources of inertia in relation to specific agents in the adoption of public sector service innovations at the organizational level in the context of the public administration in Mexico to produce public value.
Acute oral toxicity of zinc phosphide: an assessment for wild house mice (Mus musculus)
Authors: HINDS Lyn A. , HENRY Steve , VAN DE WEYER Nikki , ROBINSON Freya , RUSCOE Wendy A. , BROWN Peter R. 
Published: June 2022

AbstractIrregular plagues of house mice, Mus musculus, incur major economic impacts on agricultural production in Australia. The efficacy of zinc phosphide (ZnP), the only registered broadacre control agent for mice, is reported as increasingly variable. Have mice become less sensitive over time or are they taking a sub‐lethal dose and developing aversion? In this laboratory study, the sensitivity of mice (wild caught; outbred laboratory strain) was assessed using oral gavage of a range of ZnP concentrations. The estimated LD50 values (72–79 mg ZnP/kg body weight) were similar for each mouse group but are significantly higher than previously reported. The willingness of mice to consume ZnP‐coated grains was determined. ZnP‐coated grains (50 g ZnP/kg grain) presented in the absence of alternative food were consumed and 94% of wild mice died. Mice provided with alternative food and ZnP‐coated wheat grains (either 25 or 50 g ZnP/kg grain) consumed toxic and non‐toxic grains, and mortality was lower (33–55%). If a sublethal amount of ZnP‐coated grain was consumed, aversion occurred, mostly when alternative food was present. The sensitivity of wild house mice to ZnP in Australia is significantly lower than previously assumed. Under laboratory conditions, ZnP‐coated grains coated with a new higher dose (50 g ZnP/kg grain) were readily consumed. Consumption of toxic grain occurred when alternative food was available but was decreased. Our unambiguous findings for house mice indicate a re‐assessment of the ZnP loading for baits used for control of many rodents around the world may be warranted.
NF‐κB‐dependent secretome of senescent cells can trigger neuroendocrine transdifferentiation of breast cancer cells
Authors: Raynard Clotilde , Ma Xingjie , Huna Anda , Tessier Nolwenn , Massemin Amélie , Zhu Kexin , Flaman Jean‐Michel , Moulin Florentin , Goehrig Delphine , Medard Jean‐Jacques , Vindrieux David , Treilleux Isabelle , Hernandez‐Vargas Hector , Ducreux Sylvie , Martin Nadine , Bernard David 
Published: June 2022

AbstractCellular senescence is characterized by a stable proliferation arrest in response to stresses and the acquisition of a senescence‐associated secretory phenotype, called SASP, composed of numerous factors including pro‐inflammatory molecules, proteases, and growth factors. The SASP affects the environment of senescent cells, especially during aging, by inducing and modulating various phenotypes such as paracrine senescence, immune cell activity, and extracellular matrix deposition and organization, which critically impact various pathophysiological situations, including fibrosis and cancer. Here, we uncover a novel paracrine effect of the SASP: the neuroendocrine transdifferentiation (NED) of some epithelial cancer cells, evidenced both in the breast and prostate. Mechanistically, this effect is mediated by NF‐κB‐dependent SASP factors, and leads to an increase in intracellular Ca2+ levels. Consistently, buffering Ca2+ by overexpressing the CALB1 buffering protein partly reverts SASP‐induced NED, suggesting that the SASP promotes NED through a SASP‐induced Ca2+ signaling. Human breast cancer dataset analyses support that NED occurs mainly in p53 WT tumors and in older patients, in line with a role of senescent cells and its secretome, as they are increasing during aging. In conclusion, our work, uncovering SASP‐induced NED in some cancer cells, paves the way for future studies aiming at better understanding the functional link between senescent cell accumulation during aging, NED and clinical patient outcome.
Association between antenatal glucocorticoid exposure and the activity of the stress system, cognition, and behavior in 8‐ to 9‐year‐old children: A prospective observational study
Authors: Rakers Florian , Schleußner Ekkehard , Muth Isabel , Hoyer Dirk , Rupprecht Sven , Schiecke Karin , Groten Tanja , Dreiling Michelle , Kozik Valeska , Schwab Matthias , Hoyer Heike , Ligges Carolin 
Published: June 2022

AbstractIntroductionGlucocorticoid (GC) ‐induced fetal programming of the activity of the hypothalamus–pituitary–adrenal axis (HPAA) and its associated cognitive and behavioral consequences in later life have been well characterized in several animal species. However, information on humans is scarce. In this study, we examined HPAA activity markers and associated outcomes at 8 to 9 years of age among children prenatally exposed to GC for suspected preterm birth. Our hypothesis was that antenatal exposure to the betamethasone (BM) is associated with exacerbation of HPAA activity in childhood.Material and methodsProspective observational study in 31 children whose mothers received single (n = 19) or multiple (n = 12) courses of BM for threatened preterm birth but born with normal weight appropriate for the gestational age (median 37+6 weeks of gestation) compared with 38 non‐exposed, age‐matched children. Primary end point was the activity of the HPAA in response to the Trier Social Stress Test. Secondary end points were changes in autonomic nervous system (ANS) activity, cognitive performance (IQ), attention‐deficit/hyperactivity disorder (ADHD) symptoms, and electrocortical activity (EEG).ResultsThere was no statistically significant difference in HPAA activity markers between antenatal BM exposed and unexposed groups. ANS activity in BM‐exposed children shifted towards a higher parasympathetic tone reflected by a higher overall high‐frequency band power of heart rate variability. IQ scores were within normal limits for both groups; however, BM‐exposed children had lower IQ scores than the unexposed group. BM‐exposed group had marginally more ADHD core symptoms and increased electrocortical activity in the occipital brain region compared with controls. A monotonic dose–response relation between BM exposure and activity of the ANS and IQ was estimated in post‐hoc analyses.ConclusionsAntenatal exposure to BM in the context of threatened preterm birth was not associated with changes in HPAA activity in childhood. However, BM exposure may be associated with changes in ANS activity. Antenatal GC prophylaxis is a valuable and often life‐saving therapy, but its prescription may warrant a well‐balanced risk–benefit assessment.
Achieving high coverage of Kangaroo mother care practice is possible: Lessons from implementation research for accelerating scale‐up in Tigray Region, Ethiopia
Authors: Beyene Selemawit Asfaw , Hadush Marta Yemane , Gebregizabher Fisseha Ashebir , Gebremariam Dawit Seyoum , Asmelash Tirhas , Zelelow Yibrah Berhe , Amare Samson Yohannes , Abay Tedros Hailu , Medhanyie Araya Abrha 
Published: June 2022

AbstractAimTo evaluate coverage of effective Kangaroo mother care (KMC) by developing a model that would result in high coverage (≥80%) of KMC for newborn weighing less than 2000 g at birth in Tigray region, Ethiopia.MethodsThe study used formative research and continuous programme learning in iterative cycles of model development and modification conducted in close collaboration with the Tigray Regional Health Bureau. Quantitative methods were used to evaluate the various models. All study facilities were enrolled simultaneously, and hospitals and health centres were considered to become KMC‐providers.ResultsThe final scalable model implemented in two rural districts and one special urban zone of Tigray region attained the desired objective, with coverage of effective KMC of 82.3% at discharge.ConclusionAchieving high coverage of KMC is possible through the design of context‐specific implementation strategies. The key factors for success were the commitment and strong leadership from the regional health bureau, strong linkages within the health system and between different departments within health facilities, improved health worker knowledge, skills and attitudes, hospitals and health centres that supported KMC performance, and systematic generation and use of data for continuous quality improvement.
Pernio and early SARS-CoV-2 variants: natural history of a prospective cohort and the role of interferon
Authors: Ng Ashley T. , Moon John J. , Steidl Olivia R. , Bussan Hailey , Tran Jennifer M. , Luong George , Nihal Aman , Kenfield Meaghan , Frere Justin , TenOever Benjamin R. , Costa da Silva Ana C. , Mays Jacqueline W. , Cowen Edward W. , Drolet Beth A. , Singh Anne Marie , Arkin Lisa M. 
Published: June 2022

Abstract
Cases of new-onset pernio and recurrences in our cohort align tightly with trends in mean 7-day COVID-19 positivity in Wisconsin and mean temperature in Madison, Wisconsin by month.
Healing of ExcisionAl wounds on Lower legs by Secondary intention (HEALS) cohort study. Part 1: a multicentre prospective observational cohort study in patients without planned compression
Authors: Pynn Emma V. , Ransom Myka , Walker Benjamin , McGinnis Elizabeth , Brown Sarah , Gilberts Rachael , Trehan Pooja , Jayasekera Prativa S. A. , Veitch David , Hussain Walayat , Collins Jemma , Abbott Rachel Angharad , Chen Kun Sen , Nixon Jane 
Published: June 2022

Abstract

Background
There is no agreed treatment pathway following excision of keratinocyte cancer (KC). Compression therapy is considered beneficial for secondary intention healing on the lower leg; however, there is a lack of supportive evidence. To plan a randomized controlled trial (RCT), suitable data are needed. We report a multicentre prospective observational cohort study in this patient population with the intention of informing a future trial design.

Aim
To estimate the time to healing in wounds healing by secondary intention without planned postoperative compression, following excision of KC on the lower leg; to characterize the patient population, including factors affecting healing; and to assess the incidence of complications.

Methods
This was a multicentre prospective observational cohort study. Inclusion criteria were age ≥ 18 years with planned excision of KC on the lower leg and healing by secondary intention, an ankle–brachial pressure index (ABPI) of ≥ 0.8; and written informed consent. Exclusion criteria included planned excision with primary closure, skin graft or flap; compression therapy for another indication; planned compression; inability of patient to receive, comply with or tolerate high compression; or a suspected diagnosis other than KC.

Results
This study recruited 58 patients from 9 secondary care dermatology clinics. In the analysis population (n = 53), mean age was 81 years (range 25–97 years), median time to healing was 81 days (95% CI 73–92) and 45 patients (84.9%) had healing of the wound at the 6-month follow-up. The healing prognostic factors were wound parameters and ABPI. Wound infections occurred in 16 participants (30.2%). Four patients (7.5%) were admitted to hospital; three because of an infection and one because of a fall.

Conclusions
The collected data have informed the RCT preparation. A relatively high proportion (7.5–15%) of unhealed wounds, infection and hospital admissions demonstrate the need for clearly establishing potentially effective treatments to improve outcomes for this population.
Familiarity with the internet and health apps, and specific topic needs are amongst the factors that influence how online health information is used for health decisions amongst adolescents
Authors: Gazibara Tatjana , Cakic Milica , Cakic Jelena , Grgurevic Anita , Pekmezovic Tatjana 
Published: June 2022

AbstractBackgroundMany adolescents believe that online health information is reliable, particularly when they are familiar with the source of information.ObjectiveTo analyse the degree of influence of online health information on high school students' health decisions and examine whether socio‐demographic characteristics, digital literacy, use of different websites and interest in specific health topics are associated with a stronger influence of online health information on adolescents' health‐related decisions.MethodsParticipants were students from four public high schools in Belgrade, Serbia. Socio‐demographic and behavioural questionnaire as well as the e‐health literacy scale (eHEALS) were used to collect data.ResultsThe study sample comprised 702 students. A total of 79.6% of students reported that online health information influenced their health decisions to a certain extent (from ‘a little’ to ‘a lot’). Being a boy, using the internet since younger age, better self‐perceived e‐health literacy, using health apps, Google, health forums, websites of health institutions, social media and YouTube, being interested in diet/nutrition, sexually transmitted infections and cigarettes were the characteristics associated with a stronger influence of online health information on students' health decisions.ConclusionThis study provides clues about how online health‐related information can be used to adjust and enhance health promotion amongst adolescents.
Digital skin imaging applications, part I: Assessment of image acquisition technique features
Authors: Sun Mary D. , Kentley Jonathan , Wilson Britney W. , Soyer H. Peter , Curiel‐Lewandrowski Clara N. , Rotemberg Veronica , Halpern Allan C. ,   ISIC Technique Working Group
Published: June 2022

AbstractBackgroundThe rapid adoption of digital skin imaging applications has increased the utilization of smartphone‐acquired images in dermatology. While this has enormous potential for scaling the assessment of concerning skin lesions, the insufficient quality of many consumer/patient‐taken images can undermine clinical accuracy and potentially harm patients due to lack of diagnostic interpretability. We aim to characterize the current state of digital skin imaging applications and comprehensively assess how image acquisition features address image quality.Materials and methodsPublicly discoverable mobile, web, and desktop‐based skin imaging applications, identified through keyword searches in mobile app stores, Google Search queries, previous teledermatology studies, and expert recommendations were independently assessed by three reviewers. Applications were categorized by primary audience (consumer‐facing, nonhospital‐based practice, or enterprise/health system), function (education, store‐and‐forward teledermatology, live‐interactive teledermatology, electronic medical record adjunct/clinical imaging storage, or clinical triage), in‐app connection to a healthcare provider (yes or no), and user type (patient, provider, or both).ResultsJust over half (57%) of 191 included skin imaging applications had at least one of 14 image acquisition technique features. Those that were consumer‐facing, intended for educational use, and designed for both patient and physician users had significantly greater feature richness (p < 0.05). The most common feature was the inclusion of text‐based imaging tips, followed by the requirement to submit multiple images and body area matching.ConclusionVery few skin imaging applications included more than one image acquisition technique feature. Feature richness varied significantly by audience, function, and user categories. Users of digital dermatology tools should consider which applications have standardized features that improve image quality.
DYW deaminase domain has a distinct preference for neighboring nucleotides of the target RNA editing sites
Authors: Maeda Ayako , Takenaka Sachi , Wang Tenghua , Frink Brody , Shikanai Toshiharu , Takenaka Mizuki 
Published: June 2022

SUMMARYC‐to‐U RNA editing sites in plant organelles show a strong bias for neighboring nucleotides. The nucleotide upstream of the target cytidine is typically C or U, whereas A and G are less common and rare, respectively. In pentatricopeptide repeat (PPR)‐type RNA editing factors, the PPR domain specifically binds to the 5′ sequence of target cytidines, whereas the DYW domain catalyzes the C‐to‐U deamination. We comprehensively analyzed the effects of neighboring nucleotides of the target cytidines using an Escherichia coli orthogonal system. Physcomitrium PPR56 efficiently edited target cytidines when the nucleotide upstream was U or C, whereas it barely edited when the position was G or the nucleotide downstream was C. This preference pattern, which corresponds well with the observed nucleotide bias for neighboring nucleotides in plant organelles, was altered when the DYW domain of OTP86 or DYW1 was adopted. The PPR56 chimeric proteins edited the target sites even when the −1 position was G. Our results suggest that the DYW domain possesses a distinct preference for the neighboring nucleotides of the target sites, thus contributing to target selection in addition to the existing selection determined by the PPR domain.
An Analysis of the Load Distribution Characteristics of a Cylindrical Roller Bearing Including the Component Deformation and Waviness
Authors: Liu Jing , Xu Zidan , An Chenyu 
Published: June 2022

Abstract
Cylindrical roller bearings (CRBs) are key components of mechanical transmission systems. The internal load distribution and stiffness (LDAS) have significant effects on the bearing fatigue life and vibrations. It can also affect the precision, reliability, and service life of mechanical transmission systems. Due to the external loads applied on the bearing, the flexible deformations of rings and rollers would be produced, which will change the LDAS. To study the LDAS of CRB, an improved quasi-static model of CRB is established. The flexible deformations and waviness of rings and rollers are considered. An analytical calculation method based on the Newton–Raphson method is conducted to obtain the LDAS. The results show that the radial force, speed, and waviness can greatly affect the LDAS; the flexible deformations of rings and rollers increase with the increments of radial force and speed; the internal load distribution is also greatly affected by the waviness, which leads to the uneven load distribution; the radial stiffness decreases with the increment of waviness amplitude; and the waviness order has a slight effect on the radial stiffness.