bluuebunny/crossref_metadata_2025_split huggingface dataset:
Historical 8-Aminoquinoline Combinations: Not All Antimalarial Drugs Work Well Together
Authors: Shanks G. Dennis 
Published: October 2022

ABSTRACT.
Since their first use in the 1920s, 8-aminoquinolines have been known to have important toxicities such as methemoglobinemia and hemolysis. An empiric pamaquine (plasmochin) combination with quinine was widely used in the British military with relatively little toxicity. Attempts to use pamaquine with a new synthetic antimalarial drug (atabrine, quinacrine) in the 1930–1940s, however, resulted in hemolytic reactions and some deaths from renal failure. An improved 8-aminoquinoline, primaquine, was particularly effective against Plasmodium vivax relapses when combined with either quinine or chloroquine. When used in reduced daily doses (15 mg) over 2 weeks, it was safely given to many thousands of U.S. soldiers returning from Korea. CP tablets (chloroquine 300 mg, primaquine 45 mg weekly) were widely used during the Vietnam War with few hemolytic reactions and no known deaths. Efficacy and toxicity of 8-aminoquinolines is determined in part by the selection of appropriate partner drugs
The Association among Malaria in Pregnancy, Neonatal inflammation, and Neurocognitive Development in a Cohort of Malawian Infants
Authors: Buchwald Andrea G. , Boudova Sarah , Peterson Ingrid , Divala Titus , Mungwira Randy , Mawindo Patricia , Gladstone Melissa , Cairo Cristiana , Laufer Miriam K. 
Published: October 2022

ABSTRACT.
Malaria in pregnancy (MIP) causes poor birth outcomes, but its impact on neurocognitive development has not been well characterized. Between 2012 and 2014, we enrolled 307 mother–infant pairs and monitored 286 infants for neurocognitive development using the Malawi Developmental Assessment Tool at 6, 12, and 24 months of age. MIP was diagnosed from peripheral blood and placental specimens. Cord blood cytokine levels were assessed for a subset of neonates. Predictors of neurodevelopment were examined using mixed-effect logistic regression for developmental delay. Among the participants, 78 mothers (25.4%) had MIP, and 45 infants (15.7%) experienced severe neurocognitive delay. MIP was not associated with differences in cord blood cytokine levels or neurocognitive development. Preterm birth, low birthweight, increasing maternal education level, and increasing interleukin 6 levels were associated significantly with delay. The results highlight the prevalence of severe delay and a need for broad access to early childhood support in this setting.
Prevalence of Intestinal Parasitic Infections and Genotypic Distribution with Risk Factors of Enterocytozoon bieneusi in HIV Patients of Maesai Hospital, Thailand
Authors: Khositharattanakool Pathamet , Somwang Puckavadee 
Published: October 2022

Co-infections of HIV and intestinal parasites including Enterocytozoon bieneusi (E. bieneusi) are a common cause of gastrointestinal syndrome in HIV-infected people. Our study was designed to detect infection rates of intestinal parasites and the genotypic distribution of E. bieneusi, as well as probable risk factors for infection in HIV patients at Maesai hospital, Chiang Rai, Thailand. Two hundred and twenty-four stool samples from enrolled HIV-infected participants were collected and examined for parasitic infections, using microscopy and polymerase chain reaction techniques. CD4 status as well as the demographic data of HIV-infected participants was also collected and analyzed. Intestinal parasites including E. bieneusi were detected in 4.02 % of all participants. The highest intestinal parasitic infection rate was E. bieneusi (2.23 %) followed by Strongyloides stercoralis (1.34 %), Opisthorchis viverrini (0.89 %) and Giardia intestinalis (0.45 %). Intestinal parasitic infection rate of participants with CD4 count ≤ 200 cells/mm3 was significantly higher than that of participants with CD4 counts > 200 cells/mm3 (12.50 % vs 2.63 %, p = 0.027). Correspondingly, the infection rate of E. bieneusi was significantly higher in participants with CD4 count ≤ 200 cells/mm3 than in participants with CD4 count > 200 cells/mm3 (9.38 % vs 1.05 %, p = 0.022). Two genotypes of E. bieneusi, including D (n = 3) and SH8 (n = 2), were identified from 5 participants. Both of the identified genotypes were likely a zoonotic transmission. Human infection by E. bieneusi genotype SH8 was a discovery for the first time in Thailand. However, no intestinal coccidian infections were diagnosed. The low numbers of intestinal parasitic infections of this study were probably due to wide availability of antiretroviral therapy, improved health sanitation, as well as ease of access to antiparasitic medication in HIV-infected people.
HIGHLIGHTS

We discovered that HIV patients at Maesai Hospital had a low prevalence of both opportunistic and non-opportunistic intestinal parasitic infections, which was probably due to health improvement and treatment availability
We discovered Enterocytozoon bieneusi genotypes D and SH8 in HIV patients. Human infected with genotype SH8 was the first to be reported in Thailand
Low levels of CD4 cells and contact with animals were considered to be risk factors for infection with bieneusi genotypes D and SH8

GRAPHICAL ABSTRACT
KẾT QUẢ ĐIỀU TRỊ VI PHẪU THUẬT GIẢI ÉP XUNG ĐỘT MẠCH MÁU THẦN KINH VÙNG GÓC CẦU TIỂU NÃO
Authors: Đại Hà Dương , Lộc Anh Giang , Hoàng Anh Phạm , Thành Hưng Chu 
Published: October 2022

Mục tiêu: Đặc điểm lâm sàng, kết quả điều trị vi phẫu thuật xung đột mạch máu thần kinh VII, V vùng góc cầu tiểu não. Đối tượng và phương pháp nghiên cứu: 106 bệnh nhân được chẩn đoán và phẫu thuật tại trung tâm phẫu thuật thần kinh bệnh viện Việt Đức trong 3 năm (từ tháng 1 năm 2019 đến tháng 12 năm 2021). Nghiên cứu mô tả, hồi cứu kết hợp tiến cứu. Kết quả: Tỷ lệ điều trị phẫu thuật xung đột mạch máu và phức hợp thần kinh V, VII ở nữ gấp trên 2 lần nam giới. Xung đột mạch máu thần kinh chủ yếu ở vùng gần thân não. Tỷ lệ điều trị hiệu quả 89,62%, biến chứng hay gặp nhất là mất cảm giác nửa mặt tạm thời 8,62% giảm thính lực tạm thời 22,92%. Kết luận: Nguyên nhân chủ yếu gây xung đột thần kinh V là động mạch tiểu não trên (55,17%), với thần kinh VII là động mạch tiểu não trước dưới (52,05). Phẫu thuật giải ép mạch máu thần kinh mang đến hiệu quả tốt cho bệnh nhân. Mất cảm giác nửa mặt mặt tạm thời 8,62%, giảm thính lực tạm thời 22,92%... là biến chứng hay gặp tạm thời trong mổ.
KẾT QUẢ ĐIỀU TRỊ CỦA PHÁC ĐỒ CETUXIMAB KẾT HỢP HÓA CHẤT TRONG UNG THƯ ĐẠI TRỰC TRÀNG GIAI ĐOẠN IV TẠI BỆNH VIỆN K
Authors: Hữu Thắng Nguyễn , Thành Kiên Hà , Hồng Thăng Vũ 
Published: October 2022

Mục tiêu: Trong những năm gần đây, chất ức chế thụ thể yếu tố tăng trưởng biểu mô Cetuximab đã chứng minh vai trò quan trọng của nó khi kết hợp với hóa chất trong điều trị ung thư đại tràng giai đoạn IV không có đột biến gen RAS/BRAF1. Chúng tôi thực hiện nghiên cứu này nhằm đánh giá kết quả và tác dụng không mong muốn của phác đồ trên đối tượng bệnh nhân tại bệnh viện K. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả, hồi cứu trên 40 bệnh nhân chẩn đoán ung thư đại trực tràng giai đoạn IV không mang đột biến RAS/BRAF tại bệnh viện K từ tháng 7/2017 tới 8/2022, được điều trị phối hợp Cetuximab với hóa chất phác đồ mFOLFOX6 hoặc mFOLFIRI. Kết quả: Tỷ lệ đáp ứng toàn bộ (ORR) là 57,5%, trung vị thời gian sống thêm không tiến triển (PFS) là 12,0 tháng, trung vị thời gian sống thêm toàn bộ (OS) là 31,0 tháng. Các dụng phụ hay gặp nhất là tiêu chảy (60%), tăng men gan (50%) và viêm da dạng trứng cá (40%), trong đó chủ yếu là mức độ 1-2 với tỉ lệ lần lượt là 55%, 47,5% và 25%; không có tác dụng phụ trầm trọng nào được ghi nhận. Kết luận: Cetuximab kết hợp hóa chất cho tỷ lệ đáp ứng cao, thời gian sống thêm PFS, OS kéo dài, bệnh nhân dung nạp tốt.
KẾT HỢP THANG ĐIỂM SPESI VÀ CRP-HS TRONG TIÊN LƯỢNG TỬ VONG 30 NGÀY TRÊN BỆNH NHÂN TẮC ĐỘNG MẠCH PHỔI CẤP
Authors: Văn Cường Trần , Duy Linh Nguyễn , Nguyễn Đại Nghĩa Phan , Bùi Hải Hoàng 
Published: October 2022

Mục tiêu: Xác định giá trị tiên lượng tử vong ở ngày thứ 30 trên bệnh nhân tắc động mạch phổi cấp theo thang điểm sPESI, nồng độ CRP-hs và kết hợp hai thông số. Phương pháp nghiên cứu: Nghiên cứu thực hiện trên 162 bệnh nhân chẩn đoán tắc động mạch phổi cấp bằng cắt lớp vi tính đa dãy động mạch phổi có tiêm thuốc cản quang với 27 ca tử vong trong 30 ngày (16.67%). Kết quả: Giá trị tiên lượng độc lập thang điểm sPESI và nồng độ CRP-hs ở mức trung bình với AUC lần lượt là 0.74 và 0.65 với độ đặc hiệu và giá trị chẩn đoán dương tính thấp. Khi đánh giá đồng thời sPESI và CRP-hs không chỉ cải thiện độ đặc hiệu (93.3%) mà còn cải thiện giá trị tiên lượng tử vong (57.15%) trên nhóm đối tượng tắc động mạch phổi.
PENINGKATAN HASIL BELAJAR PESERTA DIDIK MELALUI METODE EKSPERIMEN DENGAN PENDEKATAN KONTEKSTUAL DI KELAS II SD KOTA KUPANG TAHUN AJARAN 2021/2022
Authors: Tanalinal Khasna Fenny , Amelia Ramadhaniyah Ahmad Rizqy , Nuriyah  
Published: October 2022

Penelitian ini bertujuan mengetahui Penerapan Metode Eksperimen dengan pendekatan Kontekstual, untuk Meningkatkan Hasil Belajar Siswa Pada Tema 6 Energi Dan Perubahanya Kelas III SD Inpres Oebobo 1 Kota Kupang. Metode dilakukan dalam penelitian ini adalah penelitian tindakan kelas. Instrumen dalam penelitian ini adalah lembar observasi aktifitas guru, lembar observasi siswa dan lembar evaluasi tes. Lembar observasi aktivitas guru teknik analisis data yang digunakan mengunakan rumus presentase. Berdasarkan hasil penelitian aktivitas guru pada siklus I memproleh presentase sebesar 73,8% (cukup baik) dan siklus II mengalami peningkatan menjadi 94,6% (sangat baik). Sedangkan hasil belajar peserta didik yang di peroleh siklus I 8 orang yang tuntas dengan ketuntasan 53,3% dan yang tidak tuntas 7 peserta didik dengan peresentase sebesar 46,6% dan pada siklus II terjadi peningkatan yaitu 13 peserta didik dengan ketuntasan sebesar 86,6%. Berdasarkan hasil penelitian dapat disimpulkan bahwa dengan menerapkan metode eksperimen dengan pendekatan kontekstual dapat meningkatkan hasil belajar peserta didik.
Process-based estimate of global-mean sea-level changes in the Common Era
Authors: Gangadharan Nidheesh , Goosse Hugues , Parkes David , Goelzer Heiko , Maussion Fabien , Marzeion Ben 
Published: October 2022

Abstract. Although the global-mean sea level (GMSL) rose over the
twentieth century with a positive contribution from thermosteric and
barystatic (ice sheets and glaciers) sources, the driving processes of GMSL
changes during the pre-industrial Common Era (PCE; 1–1850 CE) are largely
unknown. Here, the contributions of glacier and ice sheet mass variations
and ocean thermal expansion to GMSL in the Common Era (1–2000 CE) are
estimated based on simulations with different physical models. Although the
twentieth century global-mean thermosteric sea level (GMTSL) is mainly
associated with temperature variations in the upper 700 m (86 % in
reconstruction and 74 ± 8 % in model), GMTSL in the PCE is equally
controlled by temperature changes below 700 m. The GMTSL does not vary more
than ±2 cm during the PCE. GMSL contributions from the Antarctic and
Greenland ice sheets tend to cancel each other out during the PCE owing to the
differing response of the two ice sheets to atmospheric conditions. The
uncertainties of sea-level contribution from land-ice mass variations are
large, especially over the first millennium. Despite underestimating the
twentieth century model GMSL, there is a general agreement between the model and proxy-based GMSL reconstructions in the CE. Although the uncertainties remain large over the first millennium, model simulations point to glaciers as the dominant source of GMSL changes during the PCE.
Did Aristotle Invent Library Classification?
Authors: Higgins Colin 
Published: October 2022

ABSTRACT
This article tests the suggestion made by the first-century CE Greek geographer Strabo that the philosopher Aristotle was the first person to systematically organize a library, and that this classification influenced the arrangement of books in the libraries of early Greek Alexandria. It broadly examines Aristotle’s classifications and systematizing activities, and sets Aristotelian methods of knowledge organization against his Greek predecessors. It outlines what we know about Aristotle’s library, and how it might have differed from other collections of books owned by his contemporaries. It then surveys several ways Aristotelian arrangements may have posthumously exerted influence over cultural institutions in Alexandria in the late fourth and early third centuries BCE. The libraries studied are state-sponsored, private, and institutional collections. Definitive conclusions cannot be drawn due to a paucity of evidence, but the article argues that Aristotelian structures of knowledge could have had a profound effect on a nascent library culture that continues to have resonances in the ways libraries are organized today.
History and Religious Imagination: Bernard Shaw and the Irish Literary Revival—an Overview
Authors: Gahan Peter 
Published: October 2022

ABSTRACT
An overview of Bernard Shaw’s involvement in early twentieth-century Irish history, both political and cultural. Pressure building since the death of Parnell in 1891 would lead to Ireland’s independence from Britain and the establishment of the Irish free State in 1922, with Shaw’s Irish friends Horace Plunkett, Augusta Gregory, George Russell (“Æ”), and especially W. B. Yeats all prime movers in major new national cultural institutions that sprang up around the turn of the century. Through these four as well as his Irish wife, Charlotte Shaw, Shaw became involved in both the affairs of the nation as well as in Irish drama, especially Dublin’s Abbey Theatre. Yeats and his work were particularly important for Shaw’s contributions to the Irish literary revival, in which, whether in satirical, comic, or tragic modes, his Irish plays comprehend Irish mythology, history, imagination, and religious salvation.
Contribuições do pensamento decolonial sobre a ciência e sua práxis no contexto de povos e comunidades tradicionais
Authors: Martinelli Bruno Marangoni , Euzébio Umberto 
Published: October 2022

O universo das pesquisas científicas que envolvem Povos e Comunidades Tradicionais (PCT) não se limita às condições estabelecidas pelo Marco da Biodiversidade (Lei 13.123 de 2015) sobre o acesso ao conhecimento tradicional associado ao patrimônio genético (CTA). Do interesse antropológico às etnociências (etnobiologia, etnobotânica etc), já existe um grande acúmulo de conhecimentos e práticas no campo de estudos da relação cultura-natureza. Nesse contexto de pesquisa, lidamos não apenas com questões éticas, muito debatidas e com considerável avanço, mas também com as disputas inerentes ao interior da ciência, somadas às tensões geradas pelos encontros interepistêmicos. Cenário que exige cada vez mais práticas dialógicas, coprodução de conhecimento e direito ao acesso aos espaços da ciência pelos PCT enquanto sujeitos de conhecimento. Ao refletir sobre aprendizados e mudanças em curso no universo das etnociências, e desde um lugar acadêmico, partimos dos três domínios de colonialidade (do ser, do saber e do poder) para construir uma reflexão crítica sobre a ciência e sua prática nesse contexto. De início, fazemos uma discussão ontológica (domínio do ser), que pode ser útil para situar o lugar da pesquisa na realidade complexa dos PCT para, na sequência, pelo domínio do saber, olharmos para questões que tocam a epistemologia e suas teorias e metodologias, evocando o papel das “epistemologias do Sul” nesse ambiente. Finalmente, pelo domínio do poder, trazemos aspectos da realidade que estrutura a prática científica, a exemplo do acesso e da participação democrática, dos direitos conquistados e das relações pós-pesquisa.
Empirical Analysis of Influencing Factors of Women's Marital Stability Based on Spatial Econometric Empirical Model
Authors: Chen Lili 
Published: October 2022

To explore explore the influence on the meaning in life on the relapse tendency in the compulsory isolation abstainers, used the "Chinese meaning in life Questionnaire", "The Source of meaning in life Scale" and "Relapse Tendency Questionnaire", a questionnaire survey was conducted on 156 subjects in Shaoguan Compulsory Isolation Drug Rehabilitation Center.The results showed that:(1)The level of meaning in life in drug abstainers is medium, and the level of relapse tendency is low, but there are large differences among them; in the meaning in life, they pay more attention to relationship harmony and life enjoyment.(2)The self-growth dimension of drug abstainers can significantly positively affect their sense of meaning in life, and the life enjoyment dimension can significantly negatively affect their sense of meaning in life. (3)The relapse tendency of the drug abstainers is affected by their drug use years, concern for society dimension and sense of meaning in life.
Does Misery Impact Corporate Risk-Return Relationships?
Authors: Westfall Tiffany Jo , Crabtree Aaron D. 
Published: October 2022

The prior behavioral theory of the firm research documents that a firm’s external environment impacts the risk-return relationship, suggesting that drivers outside the firm are part of the risk-return puzzle. This study examines whether firms’ misery scores impact the return relationship. Using a sample of firm-year observations from 2002 to 2011, we investigate the relationship between the external environment related to misery and firms’ risk-return relationships by regressing five factors that proxy for firms’ external environments (e.g. misery levels) on risk and return. Our results suggest that both economic and non-economic external environmental factors impact firms’ risk-return relationship. Specifically, low unemployment rates and taxes are associated with higher levels of risk-taking, whereas greater access to leisure amenities decreases risk-taking. A firm’s return is negatively impacted by risk-taking associated with low unemployment and taxes and greater access to education and healthcare. However, a firm’s return is positively impacted by risk-taking associated with better air quality and lower property crime. The results suggest that a firm’s external environment impacts its performance. Therefore, future research may consider including location fixed effects to control for the unobservable external environmental factors that impact firm performance. Second, the results are of interest to practitioners as businesses can utilize the findings to develop internal programs that neutralize the external environment’s effects on firm performance.
FENOMOLOGI SOSIAL SUKU DAYAK MAANYAN
Authors: Effrata Effrata 
Published: October 2022

Tujuan dari penelitian ini adalah untuk mengetahui bagaimana system religi dan kepercayaan pada suku Dayak Maanyan dan system kesenian yang ada di Suku Dayak Maanyan. Penelitian ini menggunakan jenis penelitian kualitatif dengan menggunakan pendekatan fenomologi, yakni pendekatan penelitian yang mendalam untuk mengungkap masalah berdasarkan fenomena dan peristiwa yang terjadi. Hasil Sistem religi atau kepercayaan dan kesenian saling berkaitan erat, dimana dalam setiap ritual masyarakat juga terdapat seni yang melengkapinya, dalam sistem religi kepercayaan Asli Dayak Maanyan, Tuhan disebut Talamana Tuah Hukat (Alatala) sebagai penguasa tertinggi, membawa keselamatan dan kehidupan. Dimana dalam sistem religi juga terdapat nama-nama pemimpin ritual yang wajib ada dalam ritual yaitu seperti wadian, wadian terdiri dari wadian matei yaitu pemimpin ritual untuk upacara kematian, da nada juga wadian welum, yaitu pemimpin ritual upacara untuk orang sakit atapun orang yang ingin berobat.
Selain sistem religi juga terdapat sistem kesenian, Orang Dayak walaupun dalam kehidupan yang agak sederhana, ternyata sangat gemar akan kesenian. Menurut Riwut (1958) kesenian yang di miliki oleh orang Dayak di Kalimantan berupa seni: (1) tari; (2) suara; (3) ukir; dan (4) seni lukis.
POLITIK DINASTI DALAM KEPEMIMPINAN DESA
Authors: Lestariono Wijoko 
Published: October 2022

Politik dinasti merupakan suatu proses regenerasi kekuasaan bagi kepentingan golongan elit politik yang bertujuan untuk mempertahankan kekuasaan dengan cara menempatkan keluarga atau kerabatnya pada posisi tertentu dalam bidang pemerintahan. Rumusan masalah dalam penelitian ini yaitu: (1) Faktor apa saja yang menyebabkan terjadinya politik dinasti dalam kepemimpinan desa di Desa Mekar Jaya, (2) Apa dampak politik dinasti dalam kepemimpinan desa bagi pembangunan masyarakat di Desa Mekar Jaya.
Untuk menjawab permasalah diatas penelitian ini menggunakan metode kualitatif. Teknik pengumpulan data melalui wawancara, observasi, dan dokumentasi. Informan dalam penelitian ini berjumlah 8 orang yang terdiri dari perangkat desa, tokoh agama, serta warga masyarakat setempat. Adapun tujuan dalam penelitian yaitu untuk mengetahui: (1) Faktor penyebab terjadinya politik dinasti dalam kepemimpinan desa di Desa Mekar Jaya. (2) Dampak politik dinasti dalam kepemimpinan desa bagi pembangunan masyarakat di Desa Mekar Jaya.
Jaccard Index Cat Gradient Boosting Classification for Secured Big Data Communication
Authors: S L Swapna  , V Saravanan  
Published: October 2022

Big data is observed as a novel field dealing with datasets that are too complex in providing indispensable services for daily chores and also discovering hidden patterns. Network security has become a major issue due to big data analytics, which offers unlimited research potential. More specifically, secure data communication without a third party is a major concern. Also, as large, heterogeneous, and complex data sets emerge, existing security mechanisms cannot provide or address network threats quickly or accurately. Therefore, along with the decrease in time, accuracy and error rate are other research concerns. Accordingly, an accurate and timely big data-based secure method called Jaccard Index Cat Gradient Boosting Classification-based Secured Data Communication (JICGBC-SDC) using the Internet of Things is presented. Firstly, for each cloud user, user registration is performed by acquiring information from various sensors. Second, information is collected from the registered cloud users by means of the Jaccard Index Cat Gradient Boosting Classifier algorithm. Such a proposed algorithm imposes a lower error rate and minimizes classification time, ensuring the most reliable and secured data communication between cloud users. To ensure secure data communication, weak learners' results are combined to form a strong classifier. The proposed method is implemented in Java and tested on the CloudSim simulator for classification accuracy, classification time, and error rate. The experimental results reveal the JICGBC-SDC method increases the performance of secured data communication for error rate by 77%, classification time by 79% and classification accuracy by 25% as compared to the state-of-the-art work.
De vroege geschiedenis van de (lokale) bestuurswetenschappen: David Simons over bestuursrecht en bestuurskunde
Authors: Reussing Rik 
Published: October 2022

The early history of (local) administrative sciences: David Simons on administrative law and Public Administration
David Simons is on the list of the legal scholars that helped shape the early history of (local) administrative sciences in the Netherlands, which was dominated by the legal approach to local government. He held the first Dutch chair in Public Administration in Rotterdam, which was left by Gerrit van Poelje in 1933 and then taken over by Adriaan Koelma (first as a lecturer, and then as a professor from 1946). His work was carried out at the intersection of administrative law and Public Administration. This essay focuses on three publications: his Leiden dissertation on municipal companies from 1939, his inaugural lecture on the relationship between administration and administrators from 1948 and his preliminary advice on the relationship between administrative law and Public Administration from 1955. From 1957 onwards, he was professor of constitutional and administrative law in Rotterdam. As a government commissioner, he also played an important role in the revision of the Dutch Constitution.