bluuebunny/crossref_metadata_2025_split huggingface dataset:
New neo-Clerodane Diterpenoids Isolated from Ajuga decumbens Thunb., Planted
at Pingtan Island of Fujian Province with the Potent Anticancer Activity
Authors: Yong Jianping , Lu Canzhong , Zacchaeus Olatunde Olagoke 
Published: June 2022

Aims:
The aim of this study is to find the anticancer lead compounds or drug candidates from Chinese Traditional
Plant Medicine of Ajuga decumbens Thunb.

Background:
Ajuga decumbens Thunb. has been used in clinical for a long time in China and was selected in “Chinses
Pharmacopoeia” (part I in 1977) for its wide spectrum biological activities: such as anticancer, antioxidant, antifeedant,
antibacterial, anti-inflammatory, antihyperlipidemic, anti-cholinesterase and cytotoxicity activities. However, there are
relatively fewer studies of Ajuga decumbens Thunb. that have been carried out till now. For some years, our research
group focused on the discovery of new anticancer agents, so we studied the chemical compositions of Ajuga decumbens
Thunb., planted in Pingtan island of Fujian Province, to discover new anticancer lead compounds or candidates
from this Chinese Traditional Plant Medicine.

Methods:
The dichloromethane (DCM) extract was obtained in this work, and then this extract was used for silica gel
column chromatography to obtain different polar fractions. Several similar fractions were combined according to TLC
or HPLC analysis. The combined fractions were isolated by preparative TLC or preparative HPLC to obtain the pure
compounds and HPLC was used to detect the purity. All isolated compounds were determined by NMR (1HNMR,
13CNMR, DEPT, HMBC, HSQC, 1H-1H COSY and NOESY), HRESIMS and single crystal X-ray diffraction methods.
The in vitro anticancer activity was evaluated using CCK8 method.

Result:
Seven compounds [three new compounds 1-3； and four known compounds (Ajugacumbins A, Ajugacumbin
B, Ajugamarin A2 and Ajugamarin A1)] were isolated from Ajuga decumbens Thunb. in this work, and
their structures were confirmed. The biological evaluation showed that 3 and Ajugamarin A1 exhibited potent in vitro
anticancer activity both against A549 cell lines with IC50s=71.4 μM and 76.7 μM; and against Hela cell lines with
IC50s=71.6 mM and 5.39×10-7 μM, respectively.

Conclusion:
Compounds (3 and Ajugamarin A1) can be regarded as the lead compounds for the development of anticancer
agents.
Treatment with Biostimulants Extracted from Salix babylonica L. Induces
Drought Stress Tolerance in Zoysia tenuifolia
Authors: Ri Kum Chol , Ri Jin Ui , Gao Yang 
Published: June 2022

Background:
Drought stress limits the growth of plants and even impairs their physiological
functions. Under water stress, Zoysia tenuifolia has limited biomass, plant height, and leaf
length, as well as decreased protective enzyme activity, while it induces the accumulation of large
amounts of osmotic regulators. If a plant is in a severely water-deprived environment, its growth is
clearly inhibited, and it may even die.

Objective:
The purpose of this study was to evaluate the effect of a biostimulant, a willow extract
isolated from the bark of S.babylonica, on the drought stress of Z. tenuifolia.

Methods:
First, the change in the content of salicylic acid was evaluated through the oxidation process
by potassium permanganate after acid hydrolysis of the willow extract. Second, through leaf
spraying with Z. tenuifolia, the improvement effect on drought stress according to a reasonable concentration
of willow extract was observed.

Results:
In this paper, it was found that oxidation of potassium permanganate after acid hydrolysis
of willow extract significantly increased the content of salicylic acid, a plant growth regulator, and
that leaf spray remarkably improved the physiological index of Z. tenuifolia under drought stress
conditions.

Conclusion:
This study provides important information on the identification and utilization of willow
resources as a safe plant protector and growth regulator, and is the first study to report on the
use of these willow extracts as a source of liquid extracts acting as biostimulants in Z. tenuifolia cultivation.
Evaluation of Online Grocery Platform Alternatives Using Fuzzy ZNumbers
Authors: Sari Irem Ucal , Sergi Duygu 
Published: June 2022

Bacground:
Retail management has evolved into a new business model with the development of online shopping habits. There may be significant differences between onsite service
and online service in terms of customer expectations.

Introduction:
In this study, companies providing online grocery services in Turkey are evaluated
by examining the services they provide from the perspective of customers. Fuzzy Z numbers,
which also add the reliability of linguistic assessments to the analysis, are used in order to better
describe the uncertainty.

Methods:
Fuzzy Z-analytic hierarchy method (FZ-AHP) is used to weight the decision criteria, and
fuzzy Z-Grey relational analysis (FZ-GRA) method is used to find the best online market company.

Results:
As a result of the analysis, it is revealed that the most important criteria for online grocery
shopping are minimum order amount and brand diversity. The results are also compared with ordinary fuzzy methods.

Conclusion:
The comparison of the methods used in the study shows that although the ranks of the
criteria and alternatives are the same, using fuzzy Z linguistic scale results in a wider interval for
the weights and the scores of the alternatives, which could change the ordering, especially in cases
where criterion weights or alternative scores are very close to each other.
Effect of Ascorbic Acid Concentration on the Stability of Tartrate-Capped Silver Nanoparticles
Authors: Janah Indah Miftakhul , Roto Roto , Siswanta Dwi 
Published: June 2022

In this work, tartrate-capped silver nanoparticles (AgNPs) by reducing Ag+ ions into Ag0 using L-ascorbic acid and capping disodium tartrate have been prepared. The reaction was carried out at room temperature in an alkaline medium of pH 11 to obtain a rapid and one-step green synthesis method. The effect of L-ascorbic acid concentration on the synthesis preparation was studied to investigate their impact on the particle size, morphology, and stability of the AgNPs. The obtained tartrate capped AgNPs have SPR absorbance in 390–410 nm. They have a spherical shape, as confirmed by TEM. Increasing L-ascorbic acid concentrations from 25 mM to 100 and 200 mM leads to the 27, 17, and 11 nm particle size distributions. They give the zeta potential of –33.5, –20.8, and –21.3, respectively. After a week, the decreasing absorbance peaks were 0.151, 0.0105, and 0.336 a.u. The optimum L-ascorbic acid concentration was obtained at 100 mM, indicated by the smallest FWHM point. Thus, we may conclude that lower or higher levels of reducing agents resulted in low stability. Therefore, controlling L-ascorbic acid concentration is an important parameter. A sufficient concentration and an appropriate capping agent can produce good nanoparticle stability essential for further application.
PERBANDINGAN PENGUKURAN TDT ORDE 4 MENGGUNAKAN GNSS METODE RTK NTRIP DAN RADIO
Authors: Mahendra Gani , Panuntun Hidayat 
Published: June 2022

RTK (Real Time Kinematic) merupakan salah satu metode pengukuran dengan menggunakan GNSS yang saat ini sering digunakan di Indonesia. Berdasarkan pengiriman koreksinya RTK dibagi menjadi dua yaitu RTK NTRIP dan Radio. RTK NTRIP memanfaatkan koneksi internet dalam pengiriman koreksinya. RTK Radio memanfaatkan gelombang radio dalam pengiriman koreksinya. Berdasarkan perbedaan tersebut RTK NTRIP dan Radio memiliki keunggulan dan kekurangan saat digunakan untuk pengukuran. Tujuan dari penelitian ini untuk mengetahui metode terbaik yang dapat digunakan untuk pengukuran di lapangan. Penelitian ini dilakukan dengan melakukan pengukuran pada TDT orde 4 di desa Banyuraden kecamatan Gamping Kabupaten Sleman Provinsi Daerah Istimewa Yogyakarta. Koordinat TDT orde 4 yang diperoleh dari hasil pengukuran menggunakan metode RTK NTRIP dan Radio kemudian dibandingkan dan diuji apakah secara statistik perbedaan hasil antara kedua metode tersebut signifikan. Selain itu, standar deviasi hasil pengukuran dengan metode RTK NTRIP dan Radio digunakan untuk evaluasi pengukuran manakah yang memberikan presisi dan akurasi yang paling tinggi. Hasil standar deviasi menunjukkan bahwa metode RTK Radio memiliki tingkat presisi yang paling tinggi daripada metode RTK NTRIP. Selain melihat nilai standar deviasi, selisih antara buku tugu dan kedua metode menunjukkan bahwa hasil selisih RTK Radio yang mendekati nilai koordinat yang ada di buku tugu. Dari hasil tersebut dapat disimpulkan bahwa RTK Radio baik digunakan pada daerah yang rapat seperti di desa Banyuraden, kecamatan Gamping, Kabupaten Sleman, provinsi Daerah Istimewa Yogyakarta.
A Prospective Cohort Study on Diabetic Foot Infections with Emphasis on Identifiable Risk Factors in Patients Attending Tertiary Care Centre
Authors: Kunta Naresh , G Tulja Rani , Poludasari Shravan Kumar , Rachakonda Vidya , Pingili Lohitha Reddy 
Published: June 2022

Background: Foot infections are one of the most commonly observed complications in diabetic patients and are associated with high morbidity and risk of lower extremity amputation. Foot infections account for about 20% of all hospitalizations in people with diabetes and at least 50% of all non-traumatic lower-limb amputations performed annually.
Objective: To identify the risk factors in patients with diabetic foot infections attending tertiary care centre.
Method: It is a longitudinal prospective study in which patients attending the tertiary care centre with diabetic foot infections meeting the inclusion criteria were enrolled after obtaining the informed consent form.
Results and discussion: The results of this study revealed that the overall prevalence of DFI was seen more in males (61.42%) when compared to females (38.57%). The results also showed that the risk of DFI was more with trauma(44.28%) followed by the long duration of DM (28.57%) > wound (15.71%) > uncontrolled DM & prior foot ulcer (5.7%) which indicates a lack of awareness, longer duration of DM, poor glycemic control were the main risk factors causing diabetic foot problems. Conclusion: The results suggest that lack of awareness, poor glycemic control, and long duration of diabetes were the main risk factors causing DFI. Therefore, efforts to prevent infections should be targeted at people with traumatic foot wounds especially those that are chronic and recurrent. Foot care education would be the foremost important way of dealing with this serious problem.
Keywords: Morbidity, lower-extremity amputation, trauma, glycemic control.
Incidence and antibiotic profile of gram-positive and gram-negative bacteria isolated from aprons and tables used in abattoir located in Abraka and Obiaruku, Delta State, Nigeria
Authors: Anie Clement Oliseloke , Okafo Sinodukoo Eziuzo , Anthony Amelia-Jane Oluchi , Egbon Kayode Temitope 
Published: June 2022

This study was designed to investigate the presence of gram-positive and gram-negative bacteria in aprons and tables used in abattoirs in Abraka and Obiaruku.
A total of one hundred samples were obtained. Fifty samples were obtained from the aprons of butchers and meat vendors working in an abattoir located in Abraka and fifty samples from the sectioning tables in an abattoir located in Obiaruku using sterile swab sticks. Biochemical tests were carried out to characterize the bacterial isolates and susceptibility carried out using Kirby-Bauer disc diffusion method.
Out of the 50 aprons sampled, 47 were gram negative bacteria and 3 were gram positive bacteria. The bacteria were: Proteus spp. (16), Citrobacter spp. (15), Salmonella spp. (10), Shigella spp. (3), Aeromonas spp. (2), Providentia spp. (1), Mycobacterium spp. (1), Enterococcus spp. (1) and Streptococcus spp. (1). From the table samples, all 50 were gram negative bacteria. The gram-positive bacteria showed high susceptibility (100%) with high zones of inhibition to most antibiotics used. Gram-negative bacteria showed highest susceptibility to erythromycin (95.7%)
This study reveals that aprons and tables of butchers and meat vendors at the abattoirs are reservoir of various bacteria, some of which are food borne pathogens and are multidrug resistant. The high prevalence of some of these organisms in this study coupled with their high antibiotic resistance profile is reflective of the poor hygiene practices carried out at the abattoirs in Abraka and Obiaruku and thus, pose a serious public health concern to the consumers of meat from such abattoirs.
Keywords: Bacteria, isolates, abattoir, butchers, meat vendors
Acceptance of COVID-19 Vaccination and its Related Determinants among Adult Population in India
Authors: Jojo Chrins Thomas , Kareem Sulaikha Abdul , Jaison K Iren , Rahul Radhakrishnan , Menon N. Anand 
Published: June 2022

Background: SARS-Cov-2 (severe acute respiratory syndrome coronavirus 2) infection emerged as an epidemic and it was declared as a pandemic by the world health organization (WHO). Vaccines are developed to induce viral immunity, and vaccinating the entire population is urgent to limit the spread of the pandemic. Attaining herd immunity can be difficult with less vaccine acceptance.
Methodology: A cross-sectional study was conducted by using the snowball sampling technique. The survey was done between April 29, 2020 and May 19, 2020. The total number of responses obtained was 526. The questionnaire used in this study was based on previously conducted studies to estimate the rate of COVID-19 vaccine acceptance.
Result: 97.7% of the people that participated in the study were aware about the vaccine and said that they would be able to explain what a vaccine was. 82.9% of the respondents think that they are risking their own health and the health of their family by not getting vaccinated.
This study reports that the majority of population shows acceptance of the COVID-19, however it is evident from the other study results that this rate of acceptance is not sufficient. It is essential to identify the causes for hesitancy and ways to enhance the acceptance rates. By identification of these factors, healthcare professionals can develop techniques to strategies to work on areas that cause hesitancy among people and address their concerns. The demographical variations play a major role in determining the acceptance
Conclusion: In this COVID-19 pandemic, the most promising weapon for preventing the infection is the vaccine. More awareness and education about the need for vaccination and the hazards of avoiding the vaccine should be provided to people from authenticated sources.
Keywords: COVID-19, COVID-19 vaccine, cross- sectional study, vaccine acceptance, vaccine hesitancy.
Preparation of Moisturizing Lotion from Combination Extract of Clitoria ternatea Flower and Dragon Fruit Peels
Authors: Ginting Evi Ekayanti , Fathin Lulu , Ginting Pricella , Sari Dini Permata , Parhan1 Parhan , Leny Leny 
Published: June 2022

Background: The skin is the organ that covers the entire human body and serves to protect the body from outside influences, so that the skin needs to be protected. The process of destruction of the skin characterized by the appearance of wrinkles, dried and cracked. Skin damage can occur due to the sun's rays. Antioxidants are needed to prevent, inhibit structural damage of the skin. This study aims to determine the best concentration from a combination of Clitoria ternatea L. flower extract and dragon fruit (Hylocereus Polyrhizus (F.A.C. Weber) Britton & Rose) peel extract in lotion formulation. The research was conducted by making extract preparation and formulate in lotion by differentiating its concentration F1 (5%:5%), F2 (3%:6%), F3 (7%:3.5%). The results: Lotion of combination Clitoria ternatea L flower and dragon fruit peel extract with concentration F3 (7%:3.5%), showed the best effect, because it gives higher moisture increase compared to initial conditions, from to 32.6% become 65.2% after 4 weeks of usage. The conclusion: Combination Clitoria ternatea L. flower and dragon fruit peel extract can be formulated as a moisturizing lotion and with best combination in 7%: 3.5%.
Keywords: Lotion, Combination, Extract, Flower Clitoria ternatea , Dragon Fruit Peels
Antiradical and inhibitory activities of hydroethanolic extracts of Phyllanthus amarus and Striga hermonthica on α-amylase
Authors: ZANTE Abdoul Aziz , SOMDA Martin Bienvenu , OUATTARA Lassina , ZOUNGO Daouda , PODA F. Daniel , OUEDRAOGO R. Justin , SANOU Yacouba , KABRE B. Pawendé , KONATE K. Abdourasmane , OUEDRAOGO Georges Anicet 
Published: June 2022

Objective: The aim of this study was to evaluate the antiradical and inhibitory activity of whole plant extracts of Phyllanthus amarus and Striga hermonthica on α-amylase.
Methods: The crude 70% (v/v) hydroethanolic extracts obtained were used for the assay of polyphenols, the antiradical test with DPPH, the test for the inhibition of α-amylase with DNS (3,5-dinitrosalicylic). The enzyme extracts were obtained from sorghum malt (Sorghum bicolor).
Results: It appears from this study that the extract of P. amarus was richer in polyphenols than the extract of S. hermonthica. Regarding the antiradical activity, the extract of S. hermonthica showed an IC50 of 339.06 ± 1.43 µg/mL against 77.74 ±2.73 µg/mL for the extract of P. amarus. Regarding the anti α-amylase activity, the extract of P. amarus inhibited IMS127 and KMTC 274 respectively 43.64 ±0.59% and 66.28 ±1.97%. On the other hand, the extract of S. hermonthica presented an inhibition of 3.93 ±0.91% on IMS127 and 14.85 ±1.62% on KMTC 274. The extract of P. amarus presents a good antiradical activity and anti α-amylase compared to S. hermonthica extract. In conclusion, these results partly explain the use of these plants in traditional medicine to treat or relieve people suffering from diabetes.
Keywords : α-amylase, inhibition, polyphenols, antiradical, diabetes
Local Health Traditions, Cultural Reflections and Ethno-taxonomical Information on Wild Edible Fruit Yielding Medicinal Plants in Melur Region of Madurai District, TamilNadu, India
Authors: Nazar S , Jeyaseelan M , Jayakumararaj R 
Published: June 2022

Revitalization of local health traditions (RLHT) has become an inevitable aspect of human wellbeing in the post COVID era. An ethnobotanical survey was carried out to collect information on local health traditions and cultural reflections associate with the age old use of wild edible fruits (WEFs) from common plants in Melur Region of Madurai district, TamilNadu, India as the habit of consuming WEFs is quite common among people in this region and has not been completely abandoned in particular among the age old people. Information presented in this paper has been gathered from local people using an integrated approach of botanical collections, group discussions and interviews with questionnaires during the period from Apr 2021 to Mar 2022. As much as 29 informants were interviewed, among the informants 6 were local health-care practitioners (Vidiyars). Studies on the use of WEFs from common plants in Melur resulted in collection and documentation of information on a total of 34 ethnomedicinal plant species distributed across 20 families. Medicinal plants used by local people are listed with scientific name, family, local name, plant part(s) used, mode of consumption and preparation and medicinal uses. Data collected during the study clearly indicates that fresh parts of the plant (Fruit (Ripe/ Unripe)) were more preferred in general for the preparation of medicinal formulations by the local health practitioners. Documented ethnomedicinal plants were mostly used to cure long term complications associated with diabetics, gastrointestinal disorders, skin diseases, poison bites and nervous disorders. Howsoever, results of this study is clear record to the claim that the local people still depend on medicinal plants to overcome situations like COVID pandemic as fruits from most of the plants documented serve as natural source of immune boosters. Further, in-depth studies (both In-silico and Pre Clinical trials) are expected to bring to limelight the hidden quantum of bioactive compounds in the fruits these medicinal plants and their therapeutic potential.
Keywords: RLHT; Medicinal Plants; Folklore Medicine; Wild Edible Fruits (WEFs); Ethnobotany
A Case Report on Ibuprofen Induced Toxic Epidermal Necrolysis
Authors: HarshithaChanduri  , NeelamInjeti  
Published: June 2022

Ibuprofen is a non steroidal anti-inflammatory drug that exhibits analgesic and antipyretic activities by inhibiting prostaglandin synthesis. Though available as an OTC drug, ibuprofen is potent enough to cause serious dermatologic adverse reactions like erythema multiforme, erythroderma, SJS (Stevens - Johnson syndrome), TEN (toxic epidermal necrolysis). TENis a potentially life threatening dermatologic disorder and a severe cutaneous ADR that involves skin and mucous membrane, characterized by widespread erythema, necrosis and bullous detachment, resulting in exfoliation & possible sepsis and/or death, which is most commonly drug induced. Toxic epidermal necrolysis is characterized by inappropriate immune activation in response to certain medications or their metabolites. The exact pathogenic mechanism of TEN is still uncertain. The exposure to drugs has increased with demographic shifts associated with a higher morbidity of the population. Along with this phenomenon, a rise in the incidence of adverse drug reactions (ADRs) has been observed. Hypersensitivity- syndrome associated with ibuprofen is a host-dependent idiosyncratic drug-reaction. Though ibuprofen is most widely used over the counter (OTC) medication, which is considered to be relatively safe, it is essential to understand its potential adverse effects. This rare case report addresses the fact that severe hypersensitivity reactions can occur with ibuprofen, which can be potentially dangerous and life threatening. This case report also adds a note on the diagnosis and management of Toxic Epidermal Necrolysis.
Esofagitis erosiva secundaria a radioterapia: reporte de un caso.
Authors: Calderón Franco Carlos Hernán , Muñoz Cerón Jaime Giovanny , Giraldo RIncon Daniela , Marin Castro Hailyn Andrea , Quintero Cuellar Eliana Andrea , Piñeros Torres Angela Maria 
Published: June 2022

Introducción: la esofagitis erosiva secundaria a la radioterapia es una complicación inusual del tratamiento oncológico de los tumores torácicos. Esta entidad patológica está asociada con múltiples complicaciones, lo que resulta un reto clínico para los profesionales en salud que están poco familiarizados con las manifestaciones clínicas.
Caso clínico: mujer de 64 años con cuadro clínico de 3 días de dolor torácico irradiado al epigastrio con intensidad 10/10. En el examen físico se encontró taquicárdica, hipotensa, con dolor intenso en la región hemiabdominal superior; a la palpación profunda no tenía signos de irritación peritoneal. Los paraclínicos no mostraron signos de infección local o diseminada, pero la endoscopia de vías digestivas reportó esofagitis posirradiación.
Discusión: la esofagitis erosiva posterior a la radioterapia se presenta en menos del 1 % de los casos, las manifestaciones clínicas como disfagia, odinofagia y dolor abdominal son frecuentes; el manejo sintomático inicial es conservado, con medidas de soporte como hidratación intravenosa e inhibidores de la bomba de protones (IBP). En caso de intolerancia a la vía oral se indica terapia con soporte nutricional por sonda nasogástrica o gastrostomía en los casos más graves.