bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamical limits for the molecular switching in a photoexcited material revealed by X-ray diffraction
Authors: Volte Alix , Mariette Celine , Bertoni Roman , Cammarata Marco , Dong Xu , Trzop Elzbieta , Cailleau Herve , Collet Eric , Levantino Matteo , Wulff Michael , Kubicki Jacek , Yang Feng-Lei , Boillot Marie-Laure , Corraze Benoit , Stoleriu Laurentiu , Enachescu Cristian , Lorenc Maciej 
Published: June 2022

AbstractTime-resolved studies with temporal resolution that separate molecular level dynamics from macroscopic changes, allow clear distinction between the time scales of the different degrees of freedom involved. Cooperative molecular switching in the solid state is exemplified by spin crossover phenomenon in crystals of transition metal complexes. Here we show the existence of a delay between the crystalline volume increase, and the cooperative macroscopic switching of molecular state. Using 100 ps X-ray diffraction, we track the molecular spin state and the structure of the lattice during the photoinduced low spin to high spin transition in microcrystals of [FeIII(3-MeO-SalEen)2]PF6. Model simulations explain the phenomenon with thermally activated kinetics governed by local energy barriers separating the molecular states. Such behaviour is different from that encountered in materials with no local energy barriers, where phase transformation can occur simultaneously with propagation of strain. Broadly, this motivates an optimised material design, scalable with size and intrinsic energetics.
Resilience and recovery of public transport use during COVID-19
Authors: Wang Jiaoe , Huang Jie , Yang Haoran , Levinson David 
Published: June 2022

AbstractTo better understand how public transport use varied during the first year of COVID-19, we define and measure travel behavior resilience. With trip records between November 2019 and September 2020 in Kunming, China, we identify people who relied on traveling by subway both before and after the first pandemic wave. We investigate whether and how travelers recover to their pre-pandemic mobility level. We find that public transport use recovered slowly, as urban mobility is a result of urban functionality, transport supply, social context, and inter-personal differences. In general, urban mobility represents a strengthened revisiting tendency during COVID-19, as individual’s trips occur within a more limited space. We confirm that travel behavior resilience differs by groups. Commuters recover travel frequency and length, while older people decrease frequency but retain activity space. The study suggests that policymakers take group heterogeneity and travel behavior resilience into account for transport management and city restoration.
Multi-functional multi-gate one-transistor process-in-memory electronics with foundry processing and footprint reduction
Authors: Dai Mingzhi , Song Zhitang , Lin Chun-Ho , Dong Yemin , Wu Tom , Chu Junhao 
Published: June 2022

AbstractLogic gates are fundamental components of integrated circuits, and integration strategies involving multiple logic gates and advanced materials have been developed to meet the development requirements of high-density integrated circuits. However, these strategies are still far from being widely applicable owing to their incompatibility with the modern silicon-based foundry lines. Here, we propose a silicon-foundry-line-based multi-gate one-transistor design to simplify the conventional multi-transistor logic gates into one-transistor gates, thus reducing the circuit footprint by at least 40%. More importantly, the proposed configuration could simultaneously provide the multi-functionalities of logic gates, memory, and artificial synapses. In particular, our design could mimic the artificial synapses in three dimensions while simultaneously being implemented by standard silicon-on-insulator process technology. The foundry-line-compatible one-transistor design has great potential for immediate and widespread applications in next-generation multifunctional electronics.
Introducing untargeted data-independent acquisition for metaproteomics of complex microbial samples
Authors: Pietilä Sami , Suomi Tomi , Elo Laura L 
Published: June 2022

Abstract
Mass spectrometry-based metaproteomics is a relatively new field of research that enables the characterization of the functionality of microbiota. Recently, we demonstrated the applicability of data-independent acquisition (DIA) mass spectrometry to the analysis of complex metaproteomic samples. This allowed us to circumvent many of the drawbacks of the previously used data-dependent acquisition (DDA) mass spectrometry, mainly the limited reproducibility when analyzing samples with complex microbial composition. However, the DDA-assisted DIA approach still required additional DDA data on the samples to assist the analysis. Here, we introduce, for the first time, an untargeted DIA metaproteomics tool that does not require any DDA data, but instead generates a pseudospectral library directly from the DIA data. This reduces the amount of required mass spectrometry data to a single DIA run per sample. The new DIA-only metaproteomics approach is implemented as a new open-source software package named glaDIAtor, including a modern web-based graphical user interface to facilitate wide use of the tool by the community.
Modeling the impact of COVID-19 on future tuberculosis burden
Authors: Tovar Mario , Aleta Alberto , Sanz Joaquín , Moreno Yamir 
Published: June 2022

AbstractBackgroundThe ongoing COVID-19 pandemic has greatly disrupted our everyday life, forcing the adoption of non-pharmaceutical interventions in many countries and putting public health services and healthcare systems worldwide under stress. These circumstances are leading to unintended effects such as the increase in the burden of other diseases.MethodsHere, using a data-driven epidemiological model for tuberculosis (TB) spreading, we describe the expected rise in TB incidence and mortality if COVID-associated changes in TB notification are sustained and attributable entirely to disrupted diagnosis and treatment adherence.ResultsOur calculations show that the reduction in diagnosis of new TB cases due to the COVID-19 pandemic could result in 228k (CI 187–276) excess deaths in India, 111k (CI 93–134) in Indonesia, 27k (CI 21–33) in Pakistan, and 12k (CI 9–18) in Kenya.ConclusionsWe show that it is possible to reverse these excess deaths by increasing the pre-covid diagnosis capabilities from 15 to 50% for 2 to 4 years. This would prevent almost all TB-related excess mortality that could be caused by the COVID-19 pandemic if no additional preventative measures are introduced. Our work therefore provides guidelines for mitigating the impact of COVID-19 on tuberculosis epidemic in the years to come.
Integrated stretchable pneumatic strain gauges for electronics-free soft robots
Authors: Koivikko Anastasia , Lampinen Vilma , Pihlajamäki Mika , Yiannacou Kyriacos , Sharma Vipul , Sariola Veikko 
Published: June 2022

AbstractIn soft robotics, actuators, logic and power systems can be entirely fluidic and electronics-free. However, sensors still typically rely on electric or optical principles. This adds complexity to fluidic soft robots because transducers are needed, and electrical materials have to be incorporated. Herein, we show a highly-stretchable pneumatic strain gauge based on a meandering microchannel in a soft elastomer material thus eliminating the need for an electrical signal in soft robots. Using such pneumatic sensors, we demonstrate an all-pneumatic gripper with integrated pneumatic strain gauges that is capable of autonomous closure and object recognition. The gauges can measure at least up to 300% engineering strains. The sensor exhibits a very stable signal over a 12-hour measurement period with no hysteresis. Using pneumatic sensors, all four major components of robots—actuators, logic, power, and sensors—can be pneumatic, enabling all-fluidic soft robots with proprioception and exteroception.
The insulin receptor family in the heart: new light on old insights
Authors: Clerk Angela , Sugden Peter H. 
Published: June 2022

Abstract
Insulin was discovered over 100 years ago. Whilst the first half century defined many of the physiological effects of insulin, the second emphasised the mechanisms by which it elicits these effects, implicating a vast array of G proteins and their regulators, lipid and protein kinases and counteracting phosphatases, and more. Potential growth-promoting and protective effects of insulin on the heart emerged from studies of carbohydrate metabolism in the 1960s, but the insulin receptors (and the related receptor for insulin-like growth factors 1 and 2) were not defined until the 1980s. A related third receptor, the insulin receptor-related receptor remained an orphan receptor for many years until it was identified as an alkali-sensor. The mechanisms by which these receptors and the plethora of downstream signalling molecules confer cardioprotection remain elusive. Here, we review important aspects of the effects of the three insulin receptor family members in the heart. Metabolic studies are set in the context of what is now known of insulin receptor family signalling and the role of protein kinase B (PKB or Akt), and the relationship between this and cardiomyocyte survival versus death is discussed. PKB/Akt phosphorylates numerous substrates with potential for cardioprotection in the contractile cardiomyocytes and cardiac non-myocytes. Our overall conclusion is that the effects of insulin on glucose metabolism that were initially identified remain highly pertinent in managing cardiomyocyte energetics and preservation of function. This alone provides a high level of cardioprotection in the face of pathophysiological stressors such as ischaemia and myocardial infarction.
Guest Editorial: Special issue from 9th IET Renewable Power Generation Conference
Authors: Flynn Damian , Ging John , Wu Qiuwei , Hayden Marie , Schofield Nigel , Zhao Nan 
Published: June 2022

AbstractThe 9th IET Renewable Power Generation Conference took place online in March 2021, having originally been intended to take place in Dublin, Ireland some months earlier. A major motivation for the conference was the recognition of the challenges and possibilities arising from increasing renewable shares in many countries, and the critical need for cost‐effective, reliable, and robust solutions as part of the ongoing transformation of our power and energy systems. Despite the restrictions of the pandemic, approximately 70 papers were successfully presented at the conference across 15 oral and poster sessions, covering a wide range of themes including low inertia power systems, wind power plant modelling and control, renewable energy forecasting, distribution network operation and long‐term planning, power system protection, electricity markets and system services etc. Subsequent to the conference, a number of the authors of the presented papers were invited to submit an extended version of their papers to a special issue of the IET RPG journal. Ultimately, after a thorough peer review process, 16 papers were accepted for the special issue, which have been grouped here under five main themes: electrical network operation and planning; power electronic converter control systems; flexibility/frequency support measures and electricity markets; power system security, protection and monitoring; and tidal stream energy.
An analog circuit experiment on vibrational resonance of an underdamped bistable system
Authors: Liu Jiangling , Jiang Jiahao , Ge Maomao , Li Yuanyuan , Du Luchun 
Published: June 2022

AbstractThe underdamped vibrational resonance of a bistable analogue circuit is investigated. For a wide range of damping coefficients, vibrational resonance phenomena are more robust than over‐damped states. In particular, the vibration resonance curve reenters from single peak to double peak and then to single peak again with the increase of damping coefficients, that is, a reentrance phenomenon. The experimental results are consistent with the theoretical ones. The experiment constructed a framework for amplifying weak signals within underdamped regimes.
La panencéphalite sclérosante subaiguë de la rougeole
Authors: Lebon Pierre , Gelot Antoinette , Zhang Shen-Ying , Casanova Jean-Laurent , Hauw Jean-Jacques 
Published: June 2022

La panencéphalite sclérosante subaiguë (PESS), une complication tardive de la rougeole, est encore présente lors d’épidémies de cette maladie dues aux insuffisances de la vaccination. Après un rappel historique, nous aborderons la physiopathologie de la PESS et l’importance des critères diagnostiques. De nombreux travaux portant sur les paramètres de l’immunité innée et sur ceux des réponses interféron tendent à montrer une baisse de l’activité de l’immunité cellulaire au cours de cette maladie. Nous formulons ici plusieurs hypothèses s’appuyant sur des publications concernant différentes formes de la maladie : congénitales, périnatales, formes à incubation courte, semblables à l’encéphalite aiguë à inclusions (EAI), formes d’évolution rapide, formes retrouvées chez les immunodéprimés ou chez l’adulte. Des formes familiales ont également été identifiées, suggérant une origine génétique. Selon la durée de la période de latence entre rougeole et la PESS, deux groupes de patients ont été individualisés, incitant à des analyses rétrospective et prospective des exomes de ces malades. La connaissance des gènes participant à la maladie devrait être utile pour la compréhension de la physiopathologie de la PESS mais aussi d’autres infections neurologiques tardives dues à des virus à ARN.
Is aspirin still relevant as a single pharmacological agent for venous thromboembolism prophylaxis post hip and knee arthroplasty surgery: A retrospective review
Authors: Pretorius Jacques , Nemat Nouman , Azeem Imran , Shaju Tony , Nadeem Sayed , Hammad Yasir 
Published: June 2022

Introduction: Aspirin is widely used for the prevention of venous thromboembolism (VTE) after total hip arthroplasty (THA) and total knee arthroplasty (TKA). It is well-established that the bleeding and wound complication risk for aspirin is low or equivalent to the other anticoagulant agents, but there is still ongoing controversy regarding the efficacy of aspirin for VTE prophylaxis. The current HSE (2012) guideline suggests 72 h of enoxaparin and 4 weeks of Aspirin therapy. But is this practice still relevant with more recent guidelines, NICE (2021) and SIGN (2014) suggesting that Aspirin is not recommended as a single pharmacological agent for VTE prophylaxis. Method: A Retrospective review was performed of a single centre, between January 2016 and May 2021 assessing for symptomatic VTE post-THA and TKA. All the patients received enoxaparin and aspirin as per the HSE guidelines. Using NIMIS we assessed which patients received a workup for potential symptomatic VTE and who had a confirmed VTE within 3 months post-surgery. The secondary outcome was mortality within 3 months post-surgery. Results: A total of 1178 patients (721 undergoing THR and 457 undergoing TKR) were included in the study. The number of patients who received a workup for potential symptomatic VTE was 124 of 1178 (10.53%). VTE occurred in 13 of 721 patients (1.80%) of the THR patients and 1 of 457 (0.22%) of the TKR patients, and a total of 14 of 1178 patients (1.19%). Of these 7 (0.59%) patients developed a DVT and 7 (0.59%) a PE. No patients suffered a fatal pulmonary embolism within 90 days of index surgery nor any other cause of mortality. Conclusion: Aspirin is not only still relevant but can be considered as one of the most optimal pharmacological agents in preventing VTE after THA and TKA.
Die Anamnese sichert den Erfolg – stabile Reduktion einer
Rezession durch kieferorthopädische Maßnahmen
Authors: Klinke Rebecca , Cieplik Fabian 
Published: June 2022

Zusammenfassung
Hintergrund Unter dem Begriff „Rezession“ wird das
Freiliegen der Schmelz-Zement-Grenze und Wurzeloberfläche durch apikale
Verlagerung der marginalen Gingiva verstanden. Vestibuläre Rezessionen
können sowohl bei guter als auch bei schlechter Mundhygiene auftreten
und weisen eine multifaktorielle Ätiologie auf. Da sie nicht nur ein
ästhetisches Problem für Patienten darstellen, sondern unter
anderem mit Überempfindlichkeiten, erschwerter Plaquekontrolle,
Entwicklung von kariösen und nicht-kariösen
Zahnhartsubstanzdefekten und zunehmendem parodontalen Attachmentverlust
einhergehen können, ist oftmals eine Rezessionsdeckung mittels
plastisch-parodontalchirurgischer Maßnahmen indiziert.
Fallvorstellung Bei einer 23-jährigen Patientin mit einer
Rezession an Zahn 41 (Rezessionstyp 1; 5 mm) nach bereits alio loco
erfolgter kieferorthopädischer Therapie und mit Diabetes mellitus Typ I
sollten primär durch Entfernung eines lingual geklebten verseilten
Retainers, Frenektomie des in die Rezession einstrahlenden Frenulum labiale und
kieferorthopädischer Korrektur des labialen Wurzeltorques
günstige Voraussetzungen für eine anschließend geplante
plastisch-parodontalchirurgische Rezessionsdeckung geschaffen werden. Die
Rezession konnte allerdings allein durch Frenektomie und die beschriebenen
kieferorthopädischen Maßnahmen in 8 Monaten aktiver
Behandlungszeit von 5 mm auf 2 mm reduziert und eine
Stabilität über 18 Monate dokumentiert werden. Auf die
ursprünglich geplante plastisch-parodontalchirurgische Rezessionsdeckung
konnte somit verzichtet werden.
Schlussfolgerungen Der hier dargestellte Fallbericht zeigt deutlich, dass
unter Berücksichtigung der zu Grunde liegenden Ätiologie
(labialer Wurzeltorque sowie einstrahlendes Frenulum labiale) eine Rezession Typ
1 allein durch Frenektomie und kieferorthopädische Maßnahmen
stabil gedeckt werden kann. Dies ist gerade in Fällen mit den
Therapieerfolg möglicherweise erschwerenden Allgemeinerkrankungen (wie
Diabetes mellitus Typ I im vorliegenden Fall) einer
plastisch-parodontalchirurgischen Intervention vorzuziehen.
Kieferorthopädische Therapie im parodontal kompromittierten
Gebiss – Herausforderungen, interdisziplinäre Therapie und
Grenzen
Authors: Zbidat Nermien , Kirschneck Christian 
Published: June 2022

ZusammenfassungAktuelle Daten deuten auf eine Abnahme der Prävalenz der Parodontitis
hin. Dennoch ist durch den demografischen Wandel mit einer Zunahme des
parodontalen Behandlungsbedarfes in der Bevölkerung zu rechnen. Die
kieferorthopädische Behandlung bei Erwachsenen wird somit immer
häufiger vor neue Herausforderungen gestellt werden. Hierbei ist die
korrekte Diagnose, Risikobewertung sowie eine auf die parodontalen
Verhältnisse angepasste Therapieplanung maßgeblich für
den Erfolg der Behandlung. Neben Kenntnissen der biomechanisch relevanten
Veränderungen im parodontal kompromittierten Gebiss, ist eine intensive
interdisziplinäre Zusammenarbeit zwischen Kieferorthopäden und
Parodontologen essenziell. Der vorliegende Artikel gibt einen Überblick
über die interdisziplinären Schnittpunkte sowie über die
kieferorthopädisch relevanten Folgen einer Parodontitis, die im Zuge der
Therapieplanung und -durchführung beachtet werden müssen. Ferner
werden ein interdisziplinärer Behandlungspfad sowie verschiedene
kieferorthopädische Maßnahmen vorgestellt, die im Rahmen der
interdisziplinären Parodontitistherapie zur Wiederherstellung eines
stabilen parodontalen Zustandes beitragen können.
Impflücken bei Beschäftigten in Einrichtungen der
vorschulischen Kinderbetreuung vor Einführung des
Masernschutzgesetzes
Authors: Stephan Goertz Ruediger , Gherman Elsa , Wentzlaff Holger , Drexler Hans , Wolfschmidt Anna 
Published: June 2022

Zusammenfassung
Ziel der Studie Das Masernschutzgesetz und aktualisierte Empfehlungen der
Ständigen Impfkommission (STIKO) machen den Nachweis der zweimaligen
Impfung gegen Masern für ab 1971 geborene Beschäftigte in der
Kinderbetreuung zur Pflicht. Weiterhin sollten die allgemeinen Standard- und
beruflichen STIKO-Empfehlungen umgesetzt sein. Es erfolgte daher eine
retrolektive Evaluation von Impflücken von Beschäftigten in
Einrichtungen der vorschulischen Kinderbetreuung.
Methodik Durch eine Datenbank-Abfrage der Jahre 2018 und 2019 des
B·A·D-Gesundheitszentrums Erlangen wurden insgesamt 1300
arbeitsmedizinische Vorsorgen im Bereich der vorschulischen Kinderbetreuung
erfasst. Ausgeschlossen wurden Doppelvorsorgen und Vorsorgen mit unzureichenden
Daten: 1016 Akten wurden hinsichtlich der Impflücken bezüglich
Masern, Mumps, Röteln, Varizellen, Pertussis, Hepatitis A+B und
FSME analysiert. Die Beurteilung erfolgte primär anhand des Impfpasses.
Impflücken wurden bei fehlendem, begonnenem bzw. unvollständigem
Impfschutz angenommen.
Ergebnisse In der Kohorte der 1016 Beschäftigten stieg durch die
aktualisierte STIKO-Empfehlung und die damit verbundene Änderung der
Definition eines vollständigen Masern-Impfschutzes die
Masern-Impflücke von 16,2% auf 20,6%. Weitere
Impflücken lagen bei: für Mumps 22,7%, für
Röteln 18,9%, für Windpocken 2,3%, für
Pertussis 27,8%, für Hepatitis A 61,1% und für
FSME 60,5%. Die Altersgruppe <30 Jahre zeigte geringere
Impflücken als die Altersgruppe ≥30 Jahre.
Schlussfolgerung Es bestehen altersabhängig teils erhebliche
Impflücken in der Beschäftigtenkohorte vom Erlanger
Gesundheitszentrum bezüglich der untersuchten (teils
impfpräventablen) Infektionskrankheiten. Das Masernschutzgesetz
erscheint daher als eine sinnvolle Maßnahme, um die
Masernimpflücken zu schließen. Es wird deutlich, dass im Rahmen
arbeitsmedizinischer Vorsorgen großer Beratungs- und Handlungsbedarf
hinsichtlich der Infektionsprävention durch Impfungen besteht.
Effects of Liposome-Entrapped Muramyl Tripeptide Phosphatidylethanolamine (L-MTP-PE) on the Tumor Growth and Survival of Mice Bearing Syngeneic Tumor in Combination with a Chemotherapeutic or Immunomodulatory Agent
Authors: Tanaka Motoharu , Abe Shigeru 
Published: June 2022

AbstractAntitumor activities of L-MTP-PE (Liposome entrapped myuramyl tripeptide phosphatidylethanolamine) in the combination treatment with chemo- or immune-therapeutic antitumor agents against various syngeneic tumors were tested.Against Meth A fibrosarcoma solid tumor system, L-MTP-PE showed slight but statistically significant elongation of survival days against 5-FU monotherapy in spite of its non-effect on tumor growth, when combined with 5-FU. Against liver metastasis model of M5076 carcinoma, L-MTP-PE showed a tendency of elongation of survival days by its single drug treatment, however, elongation with statistical significance was observed in the combination treatment with 5-FU in comparison with control group.These data suggest that L-MTP-PE seems to elongate the survival days of the solid tumor bearing mice and the liver metastasis model basically due to its saving effect on chemotherapeutic drug-induced immunosuppression. In the combination with an immunotherapeutic agent in mice, TNF production induced by another biological response modifier OK-432 was potentiated when primed with L-MTP-PE. L-MTP-PE also potentiate the antitumor effect of OK-432 possibly through the enhanced production of TNF-α. Combination of L-MTP-PE and OK-432 is considered to be a candidate for a new treatment model for cancer.