bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decision-analytic health economic evaluation of preventive digital public health interventions: A systematized review
Authors: Lange Oliver 
Published: April 2022

Abstract
Objectives: Digital public health (DiPH) provides novel approaches for prevention, potentially leading to long-term health benefits in resource-limited health systems. However, their cost-effectiveness is unclear. This systematized review investigates the design and results of decision-analytic health economic evaluations associated with assessing the reporting quality of primary prevention and health promotion interventions using digital tools. Methods: Studies of decision-analytic economic evaluations of digital interventions in primary prevention or health promotion were eligible. The search, on December 4, 2020, included PubMed, CINAHL, and Web of Science. First, this study extracted selected items based on the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) and on additional items. Second, ICERs were extracted and price-adjusted to compare the economic evaluation results. Third, this review assessed the included studies’ reporting quality by building a score using CHEERS. Results: The database search produced 1,938 hits. Duplicates were removed. 1,161 titles and abstracts were screened. Ten of 78 studies met the full-text inclusion criteria. The most common targets were physical activity (4) and weight loss (3). Digital applications are text messages, web-based inventions, app-based interventions, e-learning devices, and the promotion of smartphone apps. The mean of the eight ICERs that use QALY is €31.143 per QALY (min −€1.616; max €114.211). The mean of reported CHEERS items is 82% (min 59%; max 91%).Discussion: This review only includes primary prevention and health promotion and excludes other DiPH fields (e.g., secondary prevention). It focuses on decision-analytic models, excluding study-based economic evaluations. Included studies report a lack of evidence of these interventions’ effectiveness or download rates in the case of smartphone applications. Different applied models and assumptions might influence the results. Nevertheless, the review demonstrates that, using common thresholds, digital public health provides a new field for prevention that contains cost-effective interventions.
High-throughput screening of BAM inhibitors in native membrane environment
Authors: Rath Parthasarathi , Hermann Adrian , Schaefer Ramona , Agustoni Elia , Vonach Jean-Marie , Siegrist Martin , Miscenic Christian , Tschumi Andreas , Roth Doris , Bieniossek Christoph , Hiller Sebastian 
Published: April 2022

Abstract
The outer membrane insertase of Gram-negative bacteria, BAM, is a key target for urgently needed novel antibiotics. Functional reconstitutions of BAM have so far been limited to synthetic membranes and with low throughput capacity for inhibitor screening. Here, we describe a BAM functional assay in native membrane environment capable of high-throughput screening. This is achieved by employing outer membrane vesicles (OMVs) to present BAM directly in native membranes. Refolding of the model substrate OmpT by BAM was possible from the chaperones SurA and Skp, with the required SurA concentration three times higher than Skp. In the OMVs, the antibiotic darobactin displayed up to tenfold higher potency than in synthetic membranes, highlighting the impact of native-like conditions in antibiotics development. The assay was successfully miniaturized for 1536-well plates and upscaled using large scale fermentation, resulting in high-throughput capacities to screen large commercial compound libraries. Our OMV-based assay thus lays the basis for discovery, hit validation and lead expansion of novel antibiotics targeting BAM.
iMUT-seq: high-resolution DSB-induced mutation profiling reveals prevalent homologous-recombination dependent mutagenesis
Authors: Bader Aldo , Bushell Martin 
Published: April 2022

Abstract
DNA double-strand breaks (DSBs) are the most mutagenic form of DNA damage, and play a
significant role in cancer biology, neurodegeneration and aging. However, studying DSB-
induced mutagenesis is limited by our current approaches. Here, we describe iMUT-seq, a
technique that profiles DSB-induced mutations at high-sensitivity and single-nucleotide
resolution around endogenous DSBs. By depleting or inhibiting 20 DSB-repair factors we
defined their mutational signatures in detail, revealing remarkable insights into the
mechanisms of DSB-induced mutagenesis. Notably, we found that homologous-
recombination (HR) is highly mutagenic, inducing prevalent base substitutions and
mononucleotide deletions at distance from the break due to DNA-polymerase errors.
Simultaneously, HR reduced translocations, suggesting a primary role of HR in specifically
preventing genomic rearrangements. The results presented here offer new fundamental
insights into DSB-induced mutagenesis and have significant implications for our
understanding of cancer biology and the development of DDR-targeting chemotherapeutics.
Comprehensive Evaluation of Lithium-ion Battery Recycling Station Based on Pythagorean Intuitionistic Fuzzy Analysis Modified Expression Difference
Authors: Cheng Zhongwei , Wu Shaotong , Yang Lifeng , Li Xueyan , Chen Feiyu 
Published: April 2022

Abstract
With the popularity of lithium-ion battery (LIB) vehicles, End of Life-lithium-ion batteries (EoL-LIB) pollute the environment, but their recycling has great economic value. Therefore, service efficiency and location of EoL-LIB recycling station (ELRS) have become a concern. Aiming at the comprehensive evaluation of the service efficiency of ELRSs, this study constructed an evaluation index system of the service efficiency of ELRSs, including 5 first-level indicators, such as incentive factors of system sound, economic benefit, social effect, technological innovation and management innovation. In this study, the fuzzy analytic hierarchy process (FAHP), the fuzzy processing of 7-granularity language variables and the intuitionistic fuzzy weighted mean (IFWA) operator aggregate quantitative evaluation matrix were adopted. Based on the prospect theory, a weight correction model of individual expression tendency index was constructed. Secondly, we used Maximum deviation method (MDM) and Shapley fuzzy measure to build a two-stage optimization model, and then determined the optimal weight. Thirdly, according to performance function and accuracy function, we used Partition normalized weighted Bonferroni mean (PFPNWBM) operator to calculate the optimal ranking of ELRSs. Finally, an example was given to analyze the difference between the first-order linear optimization model and the two-stage optimization model, and the practical value of using Shapley function-based two-stage linear optimization model to evaluate the comprehensive service efficiency of ELRSs was verified.
Sensitive Seismic Sensors Based on Microwave Frequency Fiber Interferometers in Commercially Deployed Cables
Authors: Bogris Adonis , Nikas Thomas , Simos Christos , Simos Iraklis , Lentas Konstantinos , Melis Nikolaos , Fichtner Andreas , Bowden Daniel , Smolinski Krystyna , Mesaritakis Charis , Chochliouros Ioannis 
Published: April 2022

Abstract
The use of fiber infrastructures for environmental sensing is attracting global interest, as optical fibers emerge as low cost and easily accessible platforms exhibiting a large terrestrial deployment. Moreover, optical fiber networks offer the unique advantage of providing observations of submarine areas, where the sparse existence of permanent seismic instrumentation due to cost and difficulties in deployment limits the availability of high-resolution subsea information on natural hazards in both time and space. The use of optical techniques that leverage pre-existing fiber infrastructure can efficiently provide higher resolution coverage and pave the way for the identification of the detailed structure of the Earth especially on seismogenic submarine faults. The prevailing optical technique for use in earthquake detection and structural analysis is distributed acoustic sensing (DAS) which offers high spatial resolution and sensitivity, however is limited in range to a few tens of km. In this work, we present a novel technique which relies on the dissemination of stable microwave carriers along optical fibers in a closed loop configuration, thereby forming an interferometer that is sensitive to deformation. We call the proposed technique Microwave Frequency Fiber Interferometer (MFFI) and demonstrate its sensitivity to deformation induced by moderate-to-large earthquakes from either local or regional epicenters. MFFI signals are compared to signals recorded by accelerometers of the National Observatory of Athens, Institute of Geodynamics National Seismic Network and by a commercially available DAS interrogator operating in parallel at the same location. Remarkable agreement in dynamical behavior and strain rate estimation is achieved and demonstrated. Thus, MFFI emerges as a novel technique in the field of fiber seismometers offering critical advantages with respect to implementation cost, maximum range and simplicity.
A 9T-ST SRAM Cell with Reconfigurable Negative Bit Line Collapsed Supply Write Assist
Authors: ch Ganesh 
Published: April 2022

Abstract
This paper presents Reconfigurable Negative Bit Line Collapsed Supply Write driver circuit for 9T-ST SRAM Cell, significantly improving write performance for real-time memory applications. In deep sub-micron technology, increasing device parameter deviations significantly reduces the writeability of SRAM cells. The proposed 'RNBLCS' Write Assist technique for 9T-ST SRAM cell has 0.84×, 0.48×, 0.27× optimized write access delay and 1.05×, 1.08×, 1.19× improvement in Write Static Noise Margin (WSNM), 1.05×, 1.13×, and 1.39× improvement in Write Margin (WM), 0.96×, 0.89× and 0.72× minimum Write Trip Voltage (WTP) from Tran-NBL, CCS, and conventional write circuits respectively. The proposed ‘RNBLCS’ is functionally verified using Synopsys Custom compiler with 16nm BSIM4 model card for bulk CMOS.
Self-reported versus physician-reported severity of hand eczema - Concordance analysis based on data from the German CARPE registry
Authors: Bentz Philipp , Apfelbacher Christian , Akst Wilhelm , Molin Sonja , Bauer Andrea , Elsner Peter , Mahler Vera , von Kiedrowski Ralph , Schmitt Jochen , Weisshaar Elke 
Published: April 2022

Abstract
Background and Objective:Self-assessment of general health status includes a variety of verifiable objective and subjective criteria and shows a significant influence on patient-related outcomes such as quality of life. The objective of this study was to investigate how patients assess the severity of their chronic hand eczema compared to physicians.Patients and method:Data for 1281 patients and their physicians from the German registry “CARPE” was available at baseline. At a 2-year follow-up, the remaining 788 cases served as a comparison. Concordance analysis was performed using Bangdiwala's B.Results:Only 16.62% (baseline) and 11.47% (follow-up) of the severity ratings showed complete concordance. The baseline shows a more pessimistic, the follow-up a more optimistic assessment from the patients compared to the physicians. Women and older patients had lower agreement. Bangdiwala's B value lies at the lower border of a substantial agreement (B̂ω(baseline)=0.573, B̂ω(follow-up)=0.498).Conclusion: The assessment of the severity of hand eczema often differs between physician and patient. To ensure successful therapy and adherence, dermatologists should inquire about their patients' individual perception of the severity of the hand eczema, especially in older patients and women.
Multilocus species delimitation analyses show junior synonyms and deep-sea unknown species of genus Gaidropsarus (Teleostei: Gadiformes) in the North Atlantic/Mediterranean Sea area.
Authors: Barros-García David , COMESAÑA ÁNGEL SEBASTIÁN , BAÑÓN RAFAEL , BALDÓ FRANCISCO , ARRONTE JUAN CARLOS , FROUFE ELSA , DE CARLOS ALEJANDRO 
Published: April 2022

Abstract
Gaidropsarus Rafinesque, 1810 is a genus of marine teleost characterized by a high ecological diversity and by species inhabiting from the intertidal zone to the deep-sea. Several taxonomic conundrums have been historically present in this taxon due to its conservative morphology and the lack of available specimens. Species delimitation analyses were carried out in multiple datasets combining both mitochondrial (COI, CytB, ND2) and nuclear (Rho, ZIC1) genetic markers. Despite some incongruence between mitochondrial and nuclear data, the analyses supported the synonymy between Gaidropsarus biscayensis – Gaidropsarus macrophthalmus and the existence of a putative undescribed deep-sea Gaidropsarus species in the North Atlantic Ocean. Furthermore, recent speciation events can explain the close relationships among several Gaidropsarus species, including Gaidropsarus granti – Gaidropsarus vulgaris and Gaidropsarus argentatus – Gaidropsarus ensis. These results support previous findings highlighted through DNA Barcoding analyses. The first evidence of a complex evolutionary scenario has arisen between Gaidropsarus guttatus and Gaidropsarus mediterraneus, but further analyses will be necessary to unravel the phenomena related to it.
Pregnancy outcomes in women with pulmonary hypertension: a retrospective study in China
Authors: Lv Chengtian , Huang Yuwen , Liao Guangyuan , Wu Lichan , Chen Dunjin , Gao Yuanmei 
Published: April 2022

Abstract
Background: In recent years, with the development of monitoring conditions and the promotion and application of pulmonary vascular targeted drugs, the adverse pregnancy outcomes in women with pulmonary hypertension (PH) have been improved, but the rate of maternal mortality is still high. The purpose of this study was to describe the Maternal-fetal outcomes in pulmonary artery hypertensive pregnant women.Methods: The clinical data of 154 pregnant women with PH, who were admitted to the Third Affiliated Hospital of Guangzhou Medical University from January 2011 to December 2020 were collected and analyzed comprehensively.Results: Among patients diagnosed as PH with transcardiac color Doppler ultrasonography, 6 (3.9%) had idiopathic pulmonary hypertension (iPAH), 41 patients (26.6%) of pulmonary arterial hypertension associated with congenital heart disease (CHD-PAH) , 45 patients (45.2%) of pulmonary arterial hypertension (oPAH) related to other diseases, and 62 patients (40.3%) of pulmonary arterial hypertension (LHD-PH) related to left heart disease. Systolic pulmonary artery pressure (sPAP) was 36-49mmHg in 53.2% of patients, 50-69mmHg in 22.1% and ≥70mmHg in 24.7%. Five (3.2%) pregnant women died within 1 week after delivery; iPAH had the highest mortality rate (3/6, 50%); the incidence of heart failure during pregnancy was 14.9%, the incidence of postpartum hemorrhage was 10.4%, and cesarean section accounted for 70.1%, iatrogenic abortion 14.3%, premature infants 42.9%, low birth weight infants 44.8%, birth asphyxia infants 14.9%, fetal mortality 5.2%, neonatal mortality 1.9%. The average birth weight of perinatal infants was 2334.9±814.6g.Conclusion: There are significant differences in adverse pregnancy outcomes among pregnant women with pulmonary hypertension caused by different etiologies (iPAH, CHD-PAH, oPAH and LHD-PH). In general, iPAH got the worst prognosis, LHD-PH got the second, and then oPAH. CHD-PAH has the best prognosis relatively. Therefore, PH patients will be advised to avoid pregnancy; standardized, whole-process, and multidisciplinary assisted maternal management is the key to improving the maternal and fetal outcomes of such high-risk pregnancies.
Rolling Microswarms along Acoustic Virtual Walls
Authors: Zhang Zhiyuan , Sukhov Alexander , Harting Jens , Malgaretti Paolo , Ahmed Daniel 
Published: April 2022

Abstract
Rolling is a ubiquitous mode of transport utilized by both living organisms and engineered systems. Rolling, on the microscale, has become particularly interesting for the manipulation of microswarms, since enacting such motion does not require special prefabrication techniques. However, rolling motion has to date been restricted by the need for a physical boundary to break the spatial homogeneity of surrounding mediums, which limits its prospects for microswarm navigation and cargo delivery to locations with no boundaries. Here, in the absence of real physical boundaries, we show that chain-shaped microswarms can undergo rolling motion along virtual walls in the aqueous medium, impelled by a combination of magnetic and acoustic fields. A rotational magnetic field causes individual particles to self-assemble and rotate, while the pressure nodes generated by an acoustic standing wave field serve as virtual walls. The acoustic radiation force pushes the rotating microswarms towards a virtual wall and provides the reaction force needed to break their fore-aft motion symmetry and induce rolling. We develop an experiment-supported theoretical model to quantify the net displacement generated by rolling. Finally, we demonstrate that rolling can be achieved along arbitrary trajectories by dynamically switching the orientation of the virtual walls and the rotational directions of the magnetic field. Consequently, the concept of reconfigurable virtual walls developed here overcomes the fundamental limitation of a physical boundary being required for universal rolling movements.
Impact of kinematics on the efficiency and safety of an engine-driven file for glide path preparation in MB2 canals of maxillary molars
Authors: Araújo Larissa B. B. , Calefi Pedro H. S. , Alcalde Murilo P. , Gavini Giulio , Vivan Rodrigo R. , Duarte Marco Antonio Hungaro 
Published: April 2022

Abstract
Introduction:
To evaluate the influence of different kinematics on the efficiency and safety of an engine-driven file for glide path preparation in second mesiobuccal canals (MB2) of maxillary molars. In addition, the torsional resistance of the file was assessed after use.
Methodology:
Thirty-six maxillary first and second molars with two canals in the mesiobuccal root were selected and the anatomy of the canals was verified by micro-CT. The teeth were divided into 4 groups (n = 9) according to the kinematics used for glide path preparation: continuous rotation (CR), 30°/150° reciprocation (REC 30°/150°), 30°/90° reciprocation (REC 30°/90°), and 90° optimum glide path motion (OGP 90°). The duration of the procedure, number of canals in which the file reached the full working length (RFWL), canal volume before and after the procedure, rate of file fracture, and file torsional strength after use were evaluated. The ANOVA and Tukey tests or Kruskal-Wallis and Dunn tests were used for statistical analysis.
Results
No significant differences among the groups were found for procedure duration, success at reaching the FWL, distance from the file to apex, and number of fractured files (P > 0.05). The CR group showed a significant decrease in rotation angle compared with REC 90° and OGP 90° groups (P < 0.05). There was no significant difference in canal volume among the groups (P > 0.05).
Conclusion
The type of kinematics used did not affect the efficiency, success rate, and shaping ability of the file during glide path preparation. CR seems to induce more torsional stress than the other kinematics.
Clinical Relevance:
The glide path preparation of narrow canals such as the MB2 is difficult and accidents such as file fracture may occur. This study showed that reciprocation with different file angulations can be safer during this challenging stage.
Extraskeletal Osteosarcoma in the Parotid Gland: A Case Report and Review of Literature
Authors: Ge Xin , Wang Minglei , Zhai Xuefeng , Ma Jian , Liu Wenxiao , Wang Minxing , Wang Xiaodong 
Published: April 2022

Abstract
Background: Extraskeletal osteosarcoma (EOS) is a rare malignant soft tissue neoplasm. Notably, there are few reports on primary EOS in parotid gland and we report the highly malignant one.Case presentation: A 51-year-old man came to our hospital with a quickly growth mass in the left face discharge for 3 weeks. Computed tomography (CT) scan showed a 4.0 × 3.2 × 4.5cm mass in the left parotid area with significantly contrast enhancement. Unfortunately, recurrence of the lesions occurred after surgery in short time. Following magnetic resonance (MR) scan revealed a soft mass smaller than first one in the left maxillofacial and single-photon emission computed tomography/computed tomography (SPECT/CT) scan showed increased focal uptake in the lesion. Further, microscopic examination revealed a spindle cell malignant neoplasm with osteoid matrix. Immunohistochemical stains were positive for stabilin-2 and MDM2. The tumor was confirmed as a high-grade EOS in the parotid gland. The patient recovered well and no tumor recurrence was identified by MRI examination 7 months after operation. However, two subsequent chest CT examinations demonstrated a metastatic nodule in his upper lobe of the right lung and died in April, 2021 (13 months after radical surgery), due to lung metastatic complications.Conclusions: EOS in the parotid gland can quickly grow to giant proportions with no obvious symptoms initially. Radical surgery and adjuvant chemotherapy may be curative and need to further investigation. Clinicians should also pay attention to distant metastasis for such patients and need to timely deal with the complications if necessary.
Comprehensive analysis of the landscape characteristics of m6A regulators in acute myeloid leukemia
Authors: Liao Xinai , Chen Ling , Liu Jingru , Hu Haoran , Hou Diyu , You Ruolan , Wang Xiaoting , Huang Huifang 
Published: April 2022

Abstract
Background: Patients with acute myeloid leukemia (AML) have a poor prognosis and low overall survival (OS) rate owing to its heterogeneity and the complexity of its tumor microenvironment (TME). N6-methyladenosine (m6A) modification plays a potential role in the initiation and progression of haematopoietic malignancies. Nonetheless, compressive analysis of RNA m6A modification is rare in AML.Methods: Based on somatic mutation and copy number analysis, differential expression analysis, survival analysis, function enrichment analysis, spearman correlation analysis, gene set enrichment analyses，and a series of experiments (western blot, quantitative reverse transcription polymerase chain reaction and flow cytometry), data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database were used to assess the value of m6A regulators in the development and prognosis of AML.Results: Compared with normal samples, five m6A regulators were significantly differentially expressed in AML samples. Among them, methyltransferase-like 14 (METTL14), zinc finger CCCH-type containing 13 (ZC3H13), RNA binding motif protein 15 (RBM15) and YTH domain-containing 2 (YTHDC2) were associated with the OS of AML patients. Notably, they were successfully validated in clinical samples. Besides, three distinct m6A modification patterns were determined, and remarkable differences were observed in the expression of m6A regulators, TME infiltration characterization, functional enrichment and survival outcome among these patterns. We further found 122 m6A phenotype-related differentially expressed genes (DEGs). Functional enrichment analysis revealed that the DEGs were closely relevant to metabolism. Based on 28 prognosis-related DEGs, m6Ascore system was established to evaluate patient prognosis, patients with high m6Ascore had higher survival rates than those with low m6Ascore. Importantly, m6Ascore may serve as a potential predictor independent of TMB. Conclusion: This work provided new insight into the potential functions of m6A regulators in the initiation and progression of AML. It indicated that some m6A regulators may serve novel biomarkers to predict the prognosis of AML.