bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the incidence of radial artery occlusion using different introducer sheaths and hemostasis techniques
Authors: Patel Purveshkumar , Sethi Nishant , Patel Gaurav A. , Kalisetti Deepika , Patel Tejas M. 
Published: July 2022

AbstractBackgroundRadial artery occlusion (RAO) remains one of the most important complications of transradial access (TRA). Despite the identification of multiple predictors, the interaction between these predictors on the occurrence of RAO has not been evaluated.MethodsConsecutive patients undergoing TRA coronary angiography (CA) or percutaneous coronary intervention (PCI), were retrospectively analyzed to compare the effect of standard patent hemostasis using a one‐bladder band versus two‐bladder band with simultaneous ipsilateral ulnar artery compression and two introducer sizes on the primary endpoint of RAO. Access was obtained using 6‐Fr slender introducer sheath or 7‐Fr slender introducer sheath and hemostasis with either a one‐bladder band or a two‐bladder band. The radial artery was evaluated using ultrasound.ResultsTotal of 2019 patients undergoing CA or PCI were included in the analysis. In the one‐bladder band group, the incidence of RAO with a 6‐Fr slender introducer sheath was 4.2%. In those receiving hemostasis with a two‐bladder band, RAO occurred in 1% of patients receiving a 6‐Fr slender introducer sheath versus 0.9% in those receiving a 7‐Fr slender introducer sheath (p = 0.68). Larger radial artery diameter, larger body weight, and a two‐bladder hemostasis band with ipsilateral ulnar compression were independently associated with a lower incidence of RAO.ConclusionA two‐bladder band with simultaneous ipsilateral ulnar artery compression when used for radial artery hemostasis, is associated with a lower incidence of RAO, and can mitigate the penalty for a larger catheter with reassuring implications for use of a 7‐Fr capable system for complex transradial PCI.
Directional versus orbital atherectomy of femoropopliteal artery lesions: Angiographic and intravascular ultrasound outcomes
Authors: Babaev Anvar , Halista Michael , Bakirova Zulfiya , Avtushka Valeryia , Matsumura Mitsuaki , Maehara Akiko 
Published: July 2022

AbstractObjectivesThe aim of this study was to compare the ability of two different atherectomy modalities, the directional atherectomy system (DAS) and the orbital atherectomy system (OAS), to modify plaque and augment luminal gain as evaluated by angiography and intravascular ultrasound (IVUS) in patients with symptomatic femoro‐popliteal peripheral arterial disease (PAD).BackgroundAtherectomy is frequently utilized in the treatment of complex PAD. To date, there are no head‐to‐head comparisons of existing devices and their selection is based mostly on operator preference rather than on supportive data.MethodsThis was a single‐center, prospective, randomized trial designed to assess the impact of DAS in comparison to OAS on atherosclerotic plaque. Pre‐ and postatherectomy lesion characterization was performed by angiography and IVUS. Drug‐coated balloon (DCB) angioplasty was performed after atherectomy with similar analysis repeated.ResultsSixty patients were randomized to undergo either DAS or OAS. Pretreatment angiographic and IVUS characteristics were similar in the DAS and OAS groups. DAS led to a greater reduction in plaque volume throughout the entire lesion (5.9% vs. 1.1%, p = 0.003). This corresponded to a greater increase in total vessel and lumen volume by IVUS (161.5 mm3 vs. 50.2 mm3, p = 0.001; 178.6 mm3 vs. 47.0 mm3, p = 0.004, respectively), as well as a reduction in angiographic stenosis (40% vs. 70%, p < 0.001). After DCB, 10 patients required stenting for suboptimal results in the OAS group compared with two in the DAS group (p = 0.021).ConclusionsCompared to OAS, DAS demonstrated a greater plaque volume reduction and luminal gain with significantly fewer stents needed post‐DCB.
One Vanderbilt – Ganzglas‐Aussichtsboxen für New York
Authors: Schmitt Felix , Hilcken Jonas , Zimmermann Stefan 
Published: July 2022

AbstractIn direkter Nachbarschaft zum Grand Central Terminal wurde im Jahr 2020 der neue Wolkenkratzer One Vanderbilt mit einer Höhe von 427 m fertiggestellt. Es ist damit das derzeit vierthöchste Gebäude in New York. Das „SUMMIT One Vanderbilt“ wurde im Herbst 2021 für die Öffentlichkeit eröffnet und bietet neben einem Außendeck zwei in einer Höhe von 305 m aus der Fassade herausragende Ganzglas‐Aussichtsboxen. Um eine größtmögliche Transparenz und einen ungestörten Blick auf Manhattan zu erreichen, wurden zur Befestigung der Gläser strukturelle Verklebungen und spezielle Zapfenverbindungen aus Glas verwendet. Der Artikel beschreibt sowohl die Entwicklung der neuartigen Glasverbindungen, als auch das Design sowie die Fertigung und Montage dieser außergewöhnlichen Konstruktion.One Vanderbilt – All‐glass observation boxes for New York. In the direct vicinity of Grand Central Terminal, the new skyscraper One Vanderbilt was completed in 2020 with a height of 427 m. It is currently the fourth tallest building in New York. The “SUMMIT One Vanderbilt” was opened to the public in autumn 2021 and, in addition to an outdoor deck, offers two all‐glass observation boxes protruding from the facade at a height of 305 m. To achieve maximum transparency and an unobstructed view over Manhattan, structural bonding and special mortise‐and‐tenon joints of glass were used to secure the glass. This article describes the development of the innovative glass connections, as well as the design, fabrication and installation of this extraordinary structure.
Holz‐Glas‐Deckenelemente | Experimentelle Untersuchungen
Authors: Hochhauser Werner , Holzinger Katharina , Fadai Alireza 
Published: July 2022

AbstractIm Rahmen des FFG‐Forschungsprojektes (Nr. 875427) „Holz Glas Hybridbau | Berechnungs‐ und Bemessungskonzepte für geklebte, schubsteife Decken‐ und Dachelemente“ wird auf jahrelanger Forschung im Bereich aussteifender Holz‐Glas‐Verbundkonstruktionen (HGV) aufgesetzt. Novum hierbei ist, dass eine kombinierte Scheiben‐ und Plattentragfähigkeit studiert wird. Um die Anwendbarkeit von HGV als Plattenelement zu ermöglichen, müssen Plattenbeanspruchungen über Klötze, nicht über umlaufende Schubverklebungen abgetragen werden. Die daraus resultierende unterbrochene Schub‐verklebung wird anhand experimenteller kleiner und mittelgroßer Proben untersucht und den Ergebnissen numerischer Methoden gegenübergestellt.Timber‐glass floor elements | Experimental analyses. The FFG research project (No. 875427) “Timber‐glass hybrid composite | calculation and design concepts for glued, shear‐resistant floor and roof elements” builds on years of research in the field of stiffening timber‐glass hybrid composite (TGC). The novelty here is that a combined slab and plate load‐bearing capacity is being studied. To enable the application of HGV as a plate element, plate stresses must be transferred via blocks, not via circumferential shear bonding. The resulting interrupted shear bonding is investigated on the basis of experimental small and medium‐sized specimens and compared with the results of numerical methods. Existing analytical calculation and design concepts for HGV panels are to be extended for combined loading as a roof and floor element.
Neue Produkte mit strukturellen Silikonverklebungen
Authors: Kassnel‐Henneberg Bruno , Hamdan Ali 
Published: July 2022

AbstractAufgrund des fehlenden Verständnisses zum Tragverhalten von Silikon unter Zugbeanspruchung bei behinderter Querdehnung dürfen Klebfugen nur mit einem Seitenverhältnis von 1/3 eingesetzt werden. Durch gezielte Forschung am Institut für Statik und Konstruktion der Universität Darmstadt wurde im Rahmen einer Dissertation ein generelles Materialmodell entwickelt. Glas Trösch hat diese Forschungsarbeit mit Prüfkörpern unterstützt. Durch weitere Untersuchungen im Rahmen der bauaufsichtlichen Zulassung „SWISSRAILING FLAT“ wurde gezeigt, dass die Anwendbarkeit des „Nelder‐Drass Materialmodells” für 2K‐Silikone gegeben ist. Mit dem zusätzlich eingeführten Bemessungskonzept ist es Glas Trösch nun möglich, beliebige strukturelle Klebverbindungen zu bemessen.New products ideas with structural silicone adhesives. Due to the lack of understanding of the load‐bearing behaviour of silicone under tensile stress with constrained transverse strain, adhesive joints may only be used with an aspect ratio of 1/3. Through specific research at the Institute for Statics and Construction at the University of Darmstadt, a general material model was developed within the framework of a dissertation. Glas Trösch supported this research work with test specimens. Further investigations within the framework of the building authority approval “SWISSRAILING FLAT” showed that the applicability of the “Nelder‐Drass material model” for 2k silicones is given. With the additionally introduced design concept, it is now possible for Glas Trösch to design any structural bonded joints.
Nachhaltige Glasarchitektur durch intelligente Kleb‐ und Dichtstofflösungen
Authors: Scherer Christian , Suh Danny 
Published: July 2022

AbstractNachhaltigkeit und Energieeffizienz sind weltweit Leitbilder für die Zukunft. Auch im Bauwesen werden diese Themen angesichts des Klimawandels, steigender Energiepreise, knapper werdender Ressourcen und gesetzlicher Vorgaben immer wichtiger. Nachhaltiges Bauen erfordert neben energieeffizienten Gebäudekonzepten den Einsatz von modernen Werkstoffen in Verbindung mit einer ansprechenden architektonischen Umsetzung. Der vorliegende Beitrag demonstriert am Beispiel des in der koreanischen Metropole Seoul errichteten Parnas Towers, wie Kleb‐ und Dichtstofflösungen von H. B. Fuller | Kömmerling zur Zertifizierung nach dem Nachhaltigkeitsstandard LEED beitragen können. Die hohe Effizienz des Gebäudes wird dabei durch ein ausgeklügeltes Energiekonzept und ein abgestimmtes Gebäudemanagementsystem sichergestellt. Einen großen Anteil an diesem Erfolg haben neben den in die Fassade integrierten Photovoltaik‐Anlagen die hochwärme‐gedämmten, rundum laufenden Isolierglaselemente.Sustainable glass architecture through intelligent adhesive and sealant solutions. Sustainability and energy efficiency are models for the future worldwide. In the construction industry, too, these issues are becoming more and more important in view of climate change, rising energy prices, increasingly scarce resources and legal requirements. In addition to energy‐efficient building concepts, sustainable building requires the use of modern materials in conjunction with an attractive architectural implementation. Using the example of the Parnas Tower built in the Korean metropolis of Seoul, this article demonstrates how adhesive and sealant solutions from H. B. Fuller | Kömmerling can contribute to certification according to the LEED sustainability standard. The high efficiency of the building is ensured by a sophisticated energy concept and a coordinated building management system. In addition to the photovoltaic systems integrated into the facade, the highly thermally insulated, all‐round insulating glass elements play a major role in this success.
Myosin motors on the pathway of viral infections
Authors: Matozo Tais , Kogachi Leticia , de Alencar Bruna Cunha 
Published: July 2022

AbstractMolecular motors are microscopic machines that use energy from adenosine triphosphate (ATP) hydrolysis to generate movement. While kinesins and dynein are molecular motors associated with microtubule tracks, myosins bind to and move on actin filaments. Mammalian cells express several myosin motors. They power cellular processes such as endo‐ and exocytosis, intracellular trafficking, transcription, migration, and cytokinesis. As viruses navigate through cells, they may take advantage or be hindered by host components and machinery, including the cytoskeleton. This review delves into myosins' cell roles and compares them to their reported functions in viral infections. In most cases, the previously described myosin functions align with their reported role in viral infections, although not in all cases. This opens the possibility that knowledge obtained from studying myosins in viral infections might shed light on new physiological roles for myosins in cells. However, given the high number of myosins expressed and the variety of viruses investigated in the different studies, it is challenging to infer whether the interactions found are specific to a single virus or can be applied to other viruses with the same characteristics. We conclude that the participation of myosins in viral cycles is still a largely unexplored area, especially concerning unconventional myosins.
ISG15 deficiency features a complex cellular phenotype that responds to treatment with itaconate and derivatives
Authors: Waqas Syed Fakhar‐ul‐Hassnain , Sohail Aaqib , Nguyen Ariane Hai Ha , Usman Abdulai , Ludwig Tobias , Wegner Andre , Malik Muhammad Nasir Hayat , Schuchardt Sven , Geffers Robert , Winterhoff Moritz , Merkert Sylvia , Martin Ulrich , Olmer Ruth , Lachmann Nico , Pessler Frank 
Published: July 2022

AbstractBackgroundCongenital ISG15 deficiency is a rare autoinflammatory disorder that is driven by chronically elevated systemic interferon levels and predominantly affects central nervous system and skin.Methods and resultsWe have developed induced pluripotent stem cell‐derived macrophages and endothelial cells as a model to study the cellular phenotype of ISG15 deficiency and identify novel treatments. ISG15–/– macrophages exhibited the expected hyperinflammatory responses, but normal phagocytic function. In addition, they displayed a multifaceted pathological phenotype featuring increased apoptosis/pyroptosis, oxidative stress, glycolysis, and acylcarnitine levels, but decreased glutamine uptake, BCAT1 expression, branched chain amino acid catabolism, oxidative phosphorylation, β‐oxidation, and NAD(P)H‐dependent oxidoreductase activity. Furthermore, expression of genes involved in mitochondrial biogenesis and respiratory chain complexes II–V was diminished in ISG15–/– cells. Defective mitochondrial respiration was restored by transduction with wild‐type ISG15, but only partially by a conjugation‐deficient variant, suggesting that some ISG15 functions in mitochondrial respiration require ISGylation to cellular targets. Treatment with itaconate, dimethyl‐itaconate, 4‐octyl‐itaconate, and the JAK1/2 inhibitor ruxolitinib ameliorated increased inflammation, propensity for cell death, and oxidative stress. Furthermore, the treatments greatly improved mitochondria‐related gene expression, BCAT1 levels, redox balance, and intracellular and extracellular ATP levels. However, efficacy differed among the compounds according to read‐out and cell type, suggesting that their effects on cellular targets are not identical. Indeed, only itaconates increased expression of anti‐oxidant genes NFE2L2, HMOX1, and GPX7, and dimethyl‐itaconate improved redox balance the most. Even though itaconate treatments normalized the elevated expression of interferon‐stimulated genes, ISG15–/– macrophages maintained their reduced susceptibility to influenza virus infection.ConclusionsThese findings expand the cellular phenotype of human ISG15 deficiency and reveal the importance of ISG15 for regulating oxidative stress, branched chain amino acid metabolism, and mitochondrial function in humans. The results validate ruxolitinib as treatment for ISG15 deficiency and suggest itaconate‐based medications as additional therapeutics for this rare disorder.
Hierarchical stable election protocol for WSN‐based IoT inhabitant and environmental monitoring applications
Authors: Jeevanantham S. , Rebekka B. 
Published: July 2022

SummaryWireless sensor networks (WSNs) play an essential role in IoT applications, especially for long‐term data gathering and monitoring applications. The deployment field and the limited energy sources are two critical constraints directly influencing WSN lifespan, and both must be considered while designing a routing protocol for WSN‐based IoT applications. Routing the data consumes a significant amount of energy in such an extensive network. Several hierarchical clustering protocols have been developed in recent years to address this purpose. We propose a new hierarchical stable election protocol (HISEP), an improved version of the Stable Election Protocol (SEP) equipped with the Dual CH election algorithm using a new enhanced threshold formula. Accepting nodes' heterogeneity and incorporating Voronoi‐based cluster formation ensures that the 2D/3D WSN network stays alive for an extended period and the HISEP algorithm will be suitable for habitat tracking and environmental monitoring applications. The simulation results show that the proposed algorithm outperforms other protocols in terms of routing efficiency and network lifespan.
Busulfan associated pulmonary toxicity: A benign mimic of squamous cell carcinoma diagnosed in a bronchoalveolar lavage specimen
Authors: Selvaggi Suzanne M. 
Published: July 2022

AbstractAn uncommon case of iatrogenic cellular changes associated with busulfan therapy in a bronchoalveolar lavage of a 65‐year‐old woman who underwent bone marrow transplantation is presented and discussed. Chemotherapeutic changes are presented, and pitfalls discussed.
Standardized NEON organismal data for biodiversity research
Authors: Li Daijiang , Record Sydne , Sokol Eric R. , Bitters Matthew E. , Chen Melissa Y. , Chung Y. Anny , Helmus Matthew R. , Jaimes Ruvi , Jansen Lara , Jarzyna Marta A. , Just Michael G. , LaMontagne Jalene M. , Melbourne Brett A. , Moss Wynne , Norman Kari E. A. , Parker Stephanie M. , Robinson Natalie , Seyednasrollah Bijan , Smith Colin , Spaulding Sarah , Surasinghe Thilina D. , Thomsen Sarah K. , Zarnetske Phoebe L. 
Published: July 2022

AbstractUnderstanding patterns and drivers of species distribution and abundance, and thus biodiversity, is a core goal of ecology. Despite advances in recent decades, research into these patterns and processes is currently limited by a lack of standardized, high‐quality, empirical data that span large spatial scales and long time periods. The NEON fills this gap by providing freely available observational data that are generated during robust and consistent organismal sampling of several sentinel taxonomic groups within 81 sites distributed across the United States and will be collected for at least 30 years. The breadth and scope of these data provide a unique resource for advancing biodiversity research. To maximize the potential of this opportunity, however, it is critical that NEON data be maximally accessible and easily integrated into investigators' workflows and analyses. To facilitate its use for biodiversity research and synthesis, we created a workflow to process and format NEON organismal data into the ecocomDP (ecological community data design pattern) format that were available through the ecocomDP R package; we then provided the standardized data as an R data package (neonDivData). We briefly summarize sampling designs and data wrangling decisions for the major taxonomic groups included in this effort. Our workflows are open‐source so the biodiversity community may: add additional taxonomic groups; modify the workflow to produce datasets appropriate for their own analytical needs; and regularly update the data packages as more observations become available. Finally, we provide two simple examples of how the standardized data may be used for biodiversity research. By providing a standardized data package, we hope to enhance the utility of NEON organismal data in advancing biodiversity research and encourage the use of the harmonized ecocomDP data design pattern for community ecology data from other ecological observatory networks.
Cardiac contractility modulation therapy improves health status in patients with heart failure with preserved ejection fraction: a pilot study (CCM‐HFpEF)
Authors: Linde Cecilia , Grabowski Marcin , Ponikowski Piotr , Rao Ishu , Stagg Angela , Tschöpe Carsten 
Published: July 2022

AbstractAimsThis pilot study aimed to assess the potential benefits of cardiac contractility modulation (CCM) in patients with heart failure with preserved ejection fraction (HFpEF).Methods and resultsThis was a prospective, multicentre, single‐arm, pilot study of CCM therapy in patients with HFpEF and New York Heart Association (NYHA) class II or III. Echocardiographic parameters were measured by an echo core laboratory to determine study eligibility. After CCM device implantation, patients were followed for 24 weeks. Overall, 47 patients (mean age 74.3 ± 4.4 years, 70.2% female) were enrolled, with left ventricular ejection fraction of 59 ± 4.4%, 63.8% with hypertension, 46.8% with atrial fibrillation, 40.4% with diabetes, 31.9% with at least one heart failure hospitalization in the prior year, 61.7% in NYHA class III, and Kansas City Cardiomyopathy Questionnaire (KCCQ) overall summary score of 48.9 ± 21.7. The primary efficacy endpoint (mean change in the KCCQ overall summary score) improved by 18.0 ± 16.6 points (p < 0.001) and there was an event‐free rate of 93.6% for the primary safety endpoint (device‐ and procedure‐related complications), as adjudicated by an independent physician committee.ConclusionThis pilot study demonstrates that the benefits of CCM may extend to the HFpEF patient population. The significant improvement in health status observed, with no obvious impact on safety, suggests that utilization of CCM for patients with HFpEF could prove to be promising.
CSWS—Suppress confusion subregion in indoor image fingerprint localization
Authors: Liu Wen , Fan Tingting , Deng Zhongliang , Zhang Yingeng 
Published: July 2022

AbstractImage data can provide rich content information, which has attracted a lot of attention in the field of indoor fingerprint positioning. However, indoor image information from different locations is characterized by high content repetition, and these repetitive regions can cause the problem of insufficient differentiation of adjacent image fingerprints or even fingerprint misclassification. To solve this problem, this article proposes a confusion subregion weighted suppression strategy in the image fingerprint database. First, duplicate regions (confusion subregions) are extracted from the fingerprint database using an appropriate salient region detection method. Then the similarity of these duplicate regions in Euclidean space is defined, and the degree of influence of these regions on the distinguishability of the fingerprint database is measured. Finally, the suppression of these duplicate regions is achieved in the original image fingerprint database by introducing weighted suppression coefficients. Experiments show that the algorithm proposed in this article can achieve significant results in the fingerprint localization task of real indoor scenes and effectively improve the localization accuracy.