bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and analysis of MIMO system for THz communication using terahertz patch antenna array based on photonic crystals with graphene
Authors: Benlakehal Mohamed Elamine , Hocini Abdesselam , Khedrouche Djamel , Temmar Mohamed Nasr eddine , Denidni Tayeb Ahmed 
Published: July 2022

Abstract
In this paper, a novel multiple input/multiple output (MIMO) antenna system with a graphene-based patch antenna arrays for THz communications channel capacity enhancement has been proposed and investigated. Systematic analysis has been conducted on the graphene load conductivity by determining the operating modes related to its chemical potential. Further, the projected MIMO antenna arrays have been designed with three different approaches such as homogeneous, photonic crystals and optimized photonic crystals. The targeted MIMO antenna arrays have been compared with their radiation characteristics such as return loss, bandwidth and gain. The obtained results in CST simulations of the proposed graphene-based 1×2 patch antenna array using optimized photonic crystals substrate exhibited excellent performance improvement as compared to the homogeneous substrate and photonic crystals substrate around 0.65 THz, which achieved a peak gain of 11.80 dB and broad bandwidth greater than 614 GHz. Next, The 2x2 MIMO system scenario was studied and analyzed using the mentioned targeted MIMO antenna arrays by calculating the total path loss and the channel capacity. The obtained results showed that the proposed 2x2 MIMO system with MIMO antenna array based on the optimized photonic crystals substrate achieved the highest capacity and the lowest total loss compared to a simple MIMO antenna array based on a homogeneous substrate. The capacity was calculated as 23.64 bit/s/Hz, and this was a remarkable enhancement compared with previously reported studies. In addition, this capacity was investigated further for
different system configurations and different spacings between the transmission antennas and receiver antennas.
Enhancing the invasive traits of breast cancers by CYP1B1 via regulation of p53 to promote uPAR expression
Authors: Chun Young-Jin , Kwon Yeo-Jung , Shin Sangyun , Kwon Tae-Uk , Lee Boyoung , Kim Donghak , Moon Aree 
Published: July 2022

Abstract
Human cytochrome P450 1B1 (CYP1B1) catalyzes estrogen metabolism to produce metabolites that promote the progression of breast cancer. Since the invasive properties of cancer cells cause cancer relapse, which dramatically reduces patient survival, we investigated the new pro-invasive mechanism involving CYP1B1 in breast cancer. Exploring clinical data from invasive breast cancer patients revealed that CYP1B1 exhibits a significant correlation with various key factors for cancer invasion. In particular, urokinase-type plasminogen activator receptor (uPAR) was strongly overexpressed in invasive breast cancer patients, and CYP1B1 significantly increased uPAR expression. Interestingly, uPAR mRNA expression was elevated in invasive breast cancer patients carrying TP53 genes with driver mutations, and our results showed that CYP1B1 activates the uPAR pathway following regulation of p53 according to its mutant status. CYP1B1 suppressed wild-type p53 via transcriptional regulation, whereas it induced the oncogenic gain-of-function mutant p53R280K via protein stabilization and activation following phosphorylation on Ser15 residue of p53R280K. Collectively, our results demonstrate that CYP1B1 may reduce the relapse-free survival rate of breast cancer patients by inducing invasive traits in cancer cells via p53 regulation based on the mutation status of TP53 genes and further activation of the uPAR pathway. The elucidation of the previously unknown molecular mechanism of CYP1B1 may provide evidence for the development of effective anti-cancer therapeutic strategies that target the progression of cancer invasion.
Ground Water Management Studies Using RS &amp; GIS Techniques for Gorakhpur City
Authors: Kasaudhan Pankaj , Rishita Kumari , Singh Isha , Nishad Omkar , Kumar Ankur 
Published: July 2022

Abstract
This study included advanced technology and tool combination applications such as remote sensing, geographic information systems (GIS) & electrical resistance, potential zones of MCDA Groundwater resources. Groundwater is the most valuable and widespread resource on Earth. It is an important water source for a variety of purposes such as household, industrial and agricultural needs. In the hydrological cycle, groundwater occurs when surface water (precipitation) penetrates deep and fills the spaces between cracks in soil or sediment particles or rocks. Geology, geomorphology, precipitation, Alignment, land use, land cover (LULC), drainage density, soil type, slope, and texture were mapped. It has a weight according to the effect on the groundwater potential. Affected normalization. In this study, we use the AHP method to apply relative contributions. Vertical electric sounding was performed at various points to find the aquatic layer / fracture zone. The areas of groundwater potential depicted using these methods were divided into five categories. Zone, low, medium, medium high, high, very high potential. groundwater potential zone the depiction shows that high potential regions exist in the western and northeast regions, while there are low regions. Intermediate groundwater potential located in central and eastern. The research work plans to develop a methodology based on fuzzy logic & AHP for mapping the groundwater potential of the study area.
Shape-aware Stochastic Neighbor Embedding for Robust Data Visualisations
Authors: Li Chun-Biu , Tyrcha Joanna , Wängberg Tobias 
Published: July 2022

Abstract
Background: The t-distributed Stochastic Neighbour Embedding (t-SNE) algorithm has emerged as one of the leading methods for visualising High Dimensional (HD) data in a wide variety of fields, especially for revealing cluster structure in HD single cell transcriptomics data. However, t-SNE often fails to correctly represent hierarchical relationships between clusters and creates spurious patterns in the embedding. In this work we generalized t-SNE using shape-aware graph distances to mitigate some of the limitations of the t-SNE. Although many methods have been recently proposed to circumvent the shortcomings of t-SNE, notably Uniform manifold approximation (UMAP) and Potential of heat diffusion for affinity-based transition embedding (PHATE), we see a clear advantage of the proposed graph based method. Results: The superior performance of the proposed method is first demonstrated on simulated data, where a significant improvement compared to t-SNE, UMAP and PHATE, based on quantitative validation indices, is observed when visualizing imbalanced, nonlinear, continuous and hierarchically structured data. Thereafter the ability of the proposed method compared to the competing methods to create faithfully low dimensional embeddings is shown on two real-world data sets, the single cell transcriptomics data and the MNIST image data. In addition, the only hyper-parameter of the method can be automatically chosen in a data-driven way, which is consistently optimal across all test cases in this study. Conclusions: In this work we show that the proposed shape-aware stochastic neighbor embedding method creates low dimensional visualisations that robustly and accurately reveal key structures of high dimensional data.
Comparison of oocyte vitrification using a semi-automated or a manual closed system in human siblings: survival and transcriptomic analyses
Authors: Barberet Julie , Ducreux Bastien , Bruno Céline , Guilleman Magali , Simonot Raymond , Lieury Nicolas , Guilloteau Adrien , Bourc'his Déborah , Fauque Patricia 
Published: July 2022

Abstract
Background : Indications of oocyte vitrification increased substantially over the last decades for clinical and ethical reasons. A semi-automated vitrification system was recently developed making each act of vitrification reproducible. In this study, we evaluated the efficiency of the semi-automated technique of oocyte vitrification by survival rate, morphometric assessment and resistance to empty micro-injection gesture as compared with a manual method. Additionally, we intended to evaluate transcriptomic consequences of both techniques using single-cell RNA-seq technology.Results : Post-warming survival rate, oocyte surfaces and resistance to empty micro-injection were comparable between semi-automated and manual vitrification groups. Both oocyte vitrification techniques showed limited differences in the resulting transcriptomic profile of sibling oocytes since only 5 differentially expressed genes were identified. Additionally, there was no difference in median transcript integrity number or percentage of mitochondrial DNA between the two groups. However, a total of 108 genes were differentially expressed between fresh and vitrified oocytes (FDR<0.05) and showed over-represented of genes related to important cellular process.Conclusions : Our results provide reassurance about the influence of semi-automation as compared with the manual vitrification method. Concerning oocyte vitrification itself, no tight common transcriptomic signature associated has been observed across studies.
Protective Effect of High Body Mass Index in Elderly Critically Ill with Severe COVID-19 Pneumonia: Retrospective Cohort Study
Authors: Kurnik Marko , Božič Helena , Vindišar Anže , Kolar Petra , Podbregar Matej 
Published: July 2022

Abstract
Background
Obesity paradox for survival of critically ill is still conflicting, however it seems to be stronger in elderly. Mortality of elderly patients with COVID-19 is high. Aim of our study was to explore the prediction value of body weight on mortality of elderly critically ill with severe COVID-19.
Methods
Consecutive patients, ≥ 70 years old, were included in the final analysis. Body mass index (BMI) was recorded at admission. Classical statistics and logistic regression modelling were used.
Results
In total, 102 patients (26% female, average age 77 ± 5 years), were included. Average length of intensive care unit (ICU) stay was 11.4 ± 9.2 days. Average BMI was 29.3 ± 5.2 kg/m2. High-flow oxygenation, non-invasive ventilation and invasive mechanical ventilation were at some point used to support 33%, 38% and 68% of patients, respectively. ICU mortality was 50.0%. ICU stay was shorter in survivors (9.1 ± 8.5 vs 13.6 ± 9.4 days, p = 0.01). BMI was higher in survivors (30.5 ± 5.6 vs.28.1 ± 4.5 kg/m2, p = 0.02). 26 (51%) survivors and only 15 (29%) non-survivors had BMI ≥ 30 kg/m2 (Chi-square p = 0.025). BMI ≥ 30 kg/m2 measured at admission, adjusted for gender and chronic diseases, was related to lower ICU (odds ratio (OR): 0.33, 95% confidence interval (CI): 0.12 to 0.95, p = 0.04) and hospital (OR: 0.21, 95% CI: 0.05 to 0.82, p = 0.024) mortality.
Conclusion
Higher BMI is protective in elderly critically ill patients with severe COVID-19 that require ICU treatment. Survivors have higher BMI and shorter ICU stay.
Treatment of monogenic and digenic dominant genetic hearing loss by CRISPR-Cas9 ribonucleoprotein delivery in vivo
Authors: Alvarez Veronica Lamas , Tao Yong , Li Yiran , Du Wan , Whittaker Madelynn , Zuris John , Thompson David , Zhu Wenliang , Rameshbabu Arun Prabhu , Shu Yilai , Gao Xue , Hu Johnny , Kong Wei-Jia , Liu Xueazhong , Wu Hao , Kleinstiver Benjamin , Liu David , Chen Zheng-Yi 
Published: July 2022

Abstract
Mutations in Atp2b2, an outer hair cell (OHC) gene, cause dominant hearing loss (HL) in humans. Using a mouse model Atp2b2Obl+, with a dominant HL mutation (Oblivion), we show that liposome-mediated in vivo delivery of CRISPR-Cas9 ribonucleoprotein (RNP) complexes leads to specific editing of the Obl allele. Large deletions encompassing the Obl locus and indels were identified as the result of editing. In vivo genome editing promotes OHC survival and restores OHC function, leading to robust hearing rescue. We further show in a double-dominant mutant mouse model, in which the Tmc1 Beethoven mutation and the Atp2b2 Oblivion mutation cause di-genic genetic HL, RNP delivery targeting both mutations lead to hearing rescue. These findings suggest that liposome-RNP delivery can be used as a strategy to rescue hearing with dominant mutations in OHC genes and with di-genic mutations in the auditory hair cells, expanding therapeutics of gene editing to treat HL.
Thermal conductivity and diffusivity of human enamel and dentin measured by the light flash method
Authors: Soori Ahmad , Soori Faezeh , Kowsary Farshad , Kasraei Shahin 
Published: July 2022

Abstract
Precise information regarding the thermal properties of human tooth structure such as its thermal conductivity and diffusivity can increase the accuracy of heat transfer modeling, which has recently gained popularity. Moreover, such information is highly important in the designing and production of dental materials. Since the thermal conductivity and diffusivity of human enamel and dentin can be temperature-dependent, the light flash method was used in the present study to measure the diffusivity of human enamel, sound dentin, and carious dentin. Also, data obtained by differential scanning calorimetry (DSC) were used to measure the specific heat, and then thermal conductivity was calculated. The results revealed that by an increase in temperature, the conductivity of enamel, sound, and carious dentin increased. The conductivity of enamel at 30, 40, and 50°C was 0.81, 1.20, and 1.53W/(m.K) , respectively. These values were 0.44, 0.91, and 1.15 W/(m.K) for sound dentin, and 0.78, 1.01, and 1.33 W/(m.K) for carious dentin, respectively.
Optimal Pilot and Data Power Allocation in the Cell-Free Massive MIMO Systems
Authors: Jamshidi Safora , Mahdiyar Omid , taghizadeh Mehdi , Fatehi Mohammad h. , Ghaedi Amir 
Published: July 2022

Abstract
It is well known that joint pilot and data power control, often known as JPDPC, has a significant effect on cell-free massive multiple-input multiple-output (CFmMIMO) system performance. In this paper, the uplink performance of the CFmMIMO system is evaluated under two conflicting optimization objectives (sum spectral efficiency and proportional fairness) by considering JPDPC as an optimization variable. In the CFmMIMO system with imperfect channel state information (CSI), we first formulate a multi-objective optimization (MOO) problem that can handle the fairness sum-SE trade-off problems. Then, taking into account a total energy budget for each access point, we propose a power control approach that optimally allocates power between data symbols and pilot symbols. Due to the fact that the problem is non-convex, new algorithms based on a combination of successive convex approximation and geometric programming are used to handle it. The numerical results demonstrate the benefit of optimizing the power control over both the pilot and data powers, as contrasted to the scenarios of employing full power and simply optimizing the data powers, as was done in prior studies. Furthermore, the advantage of optimal joint power control in the low SNR regime is confirmed and demonstrated to be significant.
Prognostic value of elastic lamina staining in patients with stage III colon cancer
Authors: Bi Feifei , Li Xiaoyan , Zhang Yong , Wang Zekun , Dong Qian , Zhang Jingdong , Sun Deyu 
Published: July 2022

Abstract
Objective: The objectives of this study were to explore the feasibility of elastic lamina invasion (ELI) as a marker to evaluate the prognosis of stage III colon cancer patients.Methods: A total of 105 consecutive patients underwent radical surgery (R0 resection) for stage III colon cancer at the Cancer Hospital of China Medical University from January 2015 to December 2017. Clinicopathological features, including radiological stage and elastic lamina staining, were analysed for prognostic significance in stage III colon cancer.Results: A total of 105 patients with stage III colon cancer who met the criteria and had complete materials available were included. The median follow-up period of survivors was 41 months. During the follow-up period, 33 (31.4%) patients experienced recurrence after radical resection, and the 3-year disease-free survival (DFS) rate was 64.8%. The DFS rate of T3 ELI+ patients was significantly lower than that of T3 ELI- patients (P=0.000). The DFS rate of T3 ELI+ patients was significantly lower than that of pT4a patients (P=0.013). The DFS rate of T3 ELI- patients was significantly higher than that of pT4b patients (P=0.018). In the multivariate analysis, T3 ELI+ ([hazard ratio, HR], 8.444 [95% CI, 1.736-41.067]; P =0.008), N2 stage (HR,10.629[95% CI,3.858-29.286]; P<0.001), stage IIIC (HR, 0.136 [95% CI, 0.31-0.589]; P=0.008) and PNI (HR, 8.393 [95% CI, 2.094-33.637]; P=0.003) were independent risk factors for postoperative recurrence of stage III colon cancer.Conclusions: Elastic lamina staining is expected to become a stratified indicator of recurrence risk for patients with stage III colon cancer and can guide individualized adjuvant chemotherapy, improving patient prognosis.
Study of effect of supplementation of Moringa oleifera leaf meal (MOLM) on the production performance of lactating Murrah buffalo under loose housing system
Authors: Dhillod Sandeep , Bidhan Devender Singh , Sihag Sajjan , Sharma Vishal , Singh Man , Singh Narender 
Published: July 2022

Abstract
The present investigation has been undertaken to study the effect of Moringa oleifera supplementation on performance of lactating Murrah buffalo under loose housing system. Eighteen lactating Murrah buffaloes were assigned to three dietary treatment groups (T1, T2 and T3) resulting in six lactating buffaloes per treatment based on parity following factorial completely randomized design. The experiment was conducted for a period for 150 days postpartum (days in milk) to find the effect of supplementation of Moringa oleifera leaf meal in following treatments, namely, T1(control)- Feeding of lactating buffaloes as per Indian Council of Agricultural Research standards (2013), T2-75 g MOLM/animal/day in ration,T3- 150 g MOLM/animal/day in ration. Significantly (P < 0.05) higher milk yield (kg), 6% FCM (kg), and lactose (%) were reported in T3 treatment group as compared to T1. Significantly (P < 0.05) higher milk fat (%) and solid Not Fat (%) and total solids (%) were reported in T2 and T3 treatment group as compared to T1 while milk protein (%) remain unchanged. Peak milk yield was significantly (P < 0.05) higher in T3 treatment groups as compared to T1 (control) but Days taken to attain peak milk yield did not differ significantly among different dietary treatments. Persistency period of peak milk yield were significantly (P < 0.05) greater in T3 treatment groups as compared to T1 (control). It is inferred that MOLM supplementation in ration up to 150 grams increases milk production and production traits as well as improved milk composition.
Physical symptoms as psychiatric manifestation in medical spaces: a qualitative study
Authors: Spurrier Georgia Faith , Schulman Kai , Dibich Sofia , Benoit Laelia , Duckworth Kenneth , Martin Andrés 
Published: July 2022

Abstract
Background: Mental health and physical health issues frequently co-occur, but the impact of the psychological wellbeing on the body’s physical functioning remains poorly understood within medical spaces. Individuals living with psychiatric diagnoses in particular are at an increased risk for developing chronic health issues and may be especially disadvantaged by healthcare systems which treat the mind and body as separate entities. Methods: We analyzed 30 semi-structured interviews of individuals living with a serious mental illness or reflecting on a family member living with a serious mental illness. We deliberately sampled participants who reflected on salient experiences with co-occurring physical and mental health symptoms. All participants were associated with the National Alliance on Mental Illness (NAMI), the nation’s largest grassroots mental health organization. We coded interviews using qualitative thematic analysis with an interpretative phenomenological framework centered on participants’ subjective experiences. Results: Our analyses uncovered physical health challenges which often occur in individuals living with a psychiatric illness, emphasizing the bidirectionality of mental and physical symptoms. We identified three overarching domains: (i) manifestations, in which participants reflected on how their body responded physically to mental states; (ii) medical management, in which they discussed challenging experiences seeking medical treatment for physical symptoms while living with a mental health condition; and (iii) disjointedness, in which they reflected on challenges in navigating poorly coordinated mental and physical healthcare systems. Discussion: Participants and their medical providers struggled to incorporate mental wellbeing and its impact on physical health into overall healthcare. Given common experiences with misdiagnoses, difficulties navigating health care, and significantly delayed treatment, medical spaces may be able to improve patient experiences and satisfaction by accounting for psychological influences on health outcomes. Conclusions: Greater integration of physical and mental health care in medical spaces could improve health outcomes and reduce challenges for patients seeking treatment.
Asymmetric Dynamics of Inflation Inertia in Non-Eurozone European Countries
Authors: Özcan Mehmet 
Published: July 2022

Abstract
In the last twenty years, the European economy, which has faced two serious crises, nowadays tries to cope with the negative effects of the pandemic that has affected the whole world. Among all these negative effects, the one experienced by the society most is, without a doubt, high and permanent inflation. In this study, inflation inertia was analyzed with linear and non-linear unit root tests for the seven economies which are in non-Eurozone but are members of the European Union. The non-linear unit root tests used take both structural change and regime switching into account. Thanks to these tests, all none-linear dynamics that can be observed in the inflation series were included in the inflation inertia analysis. Moreover, the respective tests were aimed to obtain empirical data more sensitive to the shocks applied in time by Rolling Windows Sample approach. According to the obtained results, while inflation inertia was detected in Bulgaria, Croatia and Czechia, it was found out that Romania and Sweden economies are the ones with the least inflation inertia.