bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of a Mobile, Sensor-based Neurobehavioral Assessment With Digital Signal Processing and Machine-learning Analytics
Authors: Sloane Kelly L. , Mefford Joel A. , Zhao Zilong , Xu Man , Zhou Guifeng , Fabian Rachel , Wright Amy E. , Glenn Shenly 
Published: June 2022

Background:
The Miro Health Mobile Assessment Platform consists of self-administered neurobehavioral and cognitive assessments that measure behaviors typically measured by specialized clinicians.

Objective:
To evaluate the Miro Health Mobile Assessment Platform’s concurrent validity, test–retest reliability, and mild cognitive impairment (MCI) classification performance.

Method:
Sixty study participants were evaluated with Miro Health version V.2. Healthy controls (HC), amnestic MCI (aMCI), and nonamnestic MCI (naMCI) ages 64–85 were evaluated with version V.3. Additional participants were recruited at Johns Hopkins Hospital to represent clinic patients, with wider ranges of age and diagnosis. In all, 90 HC, 21 aMCI, 17 naMCI, and 15 other cases were evaluated with V.3. Concurrent validity of the Miro Health variables and legacy neuropsychological test scores was assessed with Spearman correlations. Reliability was quantified with the scores’ intraclass correlations. A machine-learning algorithm combined Miro Health variable scores into a Risk score to differentiate HC from MCI or MCI subtypes.

Results:
In HC, correlations of Miro Health variables with legacy test scores ranged 0.27–0.68. Test–retest reliabilities ranged 0.25–0.79, with minimal learning effects. The Risk score differentiated individuals with aMCI from HC with an area under the receiver operator curve (AUROC) of 0.97; naMCI from HC with an AUROC of 0.80; combined MCI from HC with an AUROC of 0.89; and aMCI from naMCI with an AUROC of 0.83.

Conclusion:
The Miro Health Mobile Assessment Platform provides valid and reliable assessment of neurobehavioral and cognitive status, effectively distinguishes between HC and MCI, and differentiates aMCI from naMCI.
Complex subsets but redundant clonality after B cells egress from spontaneous germinal centers
Authors: Castrillon Carlos , Simoni Lea , van den Broek Theo , van der Poel Cees , Akama-Garren Elliot H. , Ma Minghe , Carroll Michael C. 
Published: June 2022

ABSTRACTAffinity matured self-reactive antibodies are found in autoimmune diseases like systemic lupus erythematous. Here we used fate-mapping reporter mice and single cell transcriptomics coupled to antibody repertoire analysis to characterize the post-germinal center (GC) B cell compartment in a new mouse model of autoimmunity. Antibody secreting cells (ASCs) and memory B cells (MemBs) from spontaneous GCs grouped into multiple subclusters. ASCs matured into two terminal clusters, with distinct secretion, antibody repertoire and metabolic profiles. MemBs contained FCRL5+ and CD23+ subsets, with different in vivo localization in the spleen. GC-derived FCRL5+ MemBs share transcriptomic and repertoire properties with atypical B cells found in aging and infection and localize to the marginal zone, suggesting a similar contribution to recall responses. While transcriptomically diverse, ASC and MemB subsets maintained an underlying clonal redundancy. Therefore, self-reactive clones could escape subset-targeting therapy by perpetuation of self-reactivity in distinct subsets.
A gut commensal protist protects against virus-mediated loss of oral tolerance
Authors: Siller Magdalena , Zeng Yanlin , Sanchez Luzmariel Medina , Brigleb Pamela H. , Sangani Kishan A. , Rana Mohit , Van Der Kraak Lauren , Pandey Surya P. , Bender Mackenzie J. , Fitzgerald Britney , Hedden Lee , Fiske Kay , Taylor Gwen M. , Rahman Syed A , Galipeau Heather J. , Mullet Steven J. , Wendell Stacy G. , Watkins Simon C. , Bercik Premysl , Das Jishnu , Meisel Marlies , Jabri Bana , Dermody Terence S. , Verdú Elena F. , Hinterleitner Reinhard 
Published: June 2022

AbstractLoss of oral tolerance (LOT) to gluten, characterized by a T helper 1 (Th1) gluten-specific immune response, is a hallmark of celiac disease (CeD) and can be triggered by enteric viral infections. We hypothesized that certain gut microbes have the capacity to protect against virus-mediated LOT. By using our previously defined reovirus-mediated LOT CeD model, we discovered that the gut colonizing protist Tritrichomonas (T.) arnold promotes oral tolerance and protects against reovirus-mediated LOT by suppressing the reovirus-induced proinflammatory program of dietary-antigen-presenting CD103+ dendritic cells. Importantly, T. arnold did not affect antiviral host immunity, suggesting that T. arnold-mediated protection against T1L-induced LOT is not attributable to differences in antiviral host responses. Additionally, using gnotobiotic mice, we found that Tritrichomonas arnold colonization is sufficient to protect against reovirus-mediated LOT in the absence of the microbiota. Mechanistically, we show that Tritrichomonas arnold colonization restrains reovirus-induced inflammatory responses in dendritic cells and thus limit their ability to promote Th1 immune responses ex vivo. Finally, our studies using human stool samples support a role for Tritrichomonas sp. colonization in protecting against development of CeD. This study will motivate the design of effective therapies to prevent LOT to gluten in at-risk individuals and to reinstate tolerance to gluten in CeD patients.One Sentence SummaryTritrichomonas arnold protects against virus-mediated loss of oral tolerance to gluten and is underrepresented in celiac disease patients.
Factors associated with the uptake of Intermittent Preventive Treatment (IPTp-SP) for malaria in pregnancy: further analysis of the 2018 Nigeria Demographic and Health Survey
Authors: Kalu Godwin Okeke , Francis Joel M , Ibisomi Latifat , Chirwa Tobias , Kagura Juliana 
Published: June 2022

AbstractPregnancy-associated malaria is preventable and curable with intermittent preventive treatment with Sulfodoxine-Pyrimethamine (IPTp-SP). However, despite the effectiveness of IPTp-SP against malaria in pregnancy, the uptake among pregnant women in Nigeria remains very low. Thus, this study aimed to establish the factors associated with the uptake of at least one dose and optimal doses of IPTp-SP among pregnant women aged 15 to 49 years living in Nigeria in 2018. The study included 12,742 women aged 15 to 49 years with live births two years before or during the 2018 Nigeria Demographic Health Survey (NDHS) in the analysis. Descriptive analysis was carried out to determine the prevalence of IPTp-SP uptake. Multivariable logistic regression was used to establish the factors associated with receiving IPTp-SP during pregnancy, adjusting for possible confounding factors. Given the complex survey design, all analyses adjusted for sampling weight, stratification and clustering. The p-value of <0.05 was considered significant. In 2018, the prevalence of at least one dose of IPTp-SP was 63.6% (95% CI:62.0–65.1), and optimal doses of IPTp-SP were 16.8% (95% CI:15.8–17.8) during pregnancy. After the multivariable analysis, age group, region, frequency of ANC visits, belief in IPTp-SP effectiveness, and morbidity caused by malaria predicted the uptake of at least one IPTp-SP dose. Similar maternal characteristics, including household wealth index, spouse’s educational level and media exposure, were significantly associated with taking optimal IPTp-SP doses. For instance, women in the wealthiest households whose husbands had secondary education predicted a four-fold increase in uptake of at least one IPTp-SP dose (aOR:4.17; 95% CI:1.11–8.85).The low prevalence and regional variations of IPTp-SP uptake in the study area imply that most pregnant women in Nigeria are at substantial risk of pregnancy-associated malaria. Therefore, stakeholders should explore context-specific strategies to improve the IPTp-SP coverage across the regions in Nigeria.
Semiparametric tail-index estimation for randomly right-truncated heavy-tailed data
Authors: Mancer Saida , Necir Abdelhakim , Benchaira Souad 
Published: June 2022

PurposeThe purpose of this paper is to propose a semiparametric estimator for the tail index of Pareto-type random truncated data that improves the existing ones in terms of mean square error. Moreover, we establish its consistency and asymptotic normality.Design/methodology/approachTo construct a root mean squared error (RMSE)-reduced estimator of the tail index, the authors used the semiparametric estimator of the underlying distribution function given by Wang (1989). This allows us to define the corresponding tail process and provide a weak approximation to this one. By means of a functional representation of the given estimator of the tail index and by using this weak approximation, the authors establish the asymptotic normality of the aforementioned RMSE-reduced estimator.FindingsIn basis on a semiparametric estimator of the underlying distribution function, the authors proposed a new estimation method to the tail index of Pareto-type distributions for randomly right-truncated data. Compared with the existing ones, this estimator behaves well both in terms of bias and RMSE. A useful weak approximation of the corresponding tail empirical process allowed us to establish both the consistency and asymptotic normality of the proposed estimator.Originality/valueA new tail semiparametric (empirical) process for truncated data is introduced, a new estimator for the tail index of Pareto-type truncated data is introduced and asymptotic normality of the proposed estimator is established.
Ownership concentration and its influence on transparency and disclosures of banks in India
Authors: Bhimavarapu Venkata Mrudula , Rastogi Shailesh , Kanoujiya Jagjeevan 
Published: June 2022

PurposeThe disclosures in banks have become a matter of grave concern, especially post 2008 world financial crisis. The issue further gets exacerbated because disclosers in banks are part of the III pillar of BASEL-II floated in 1999, and despite that, banks face challenges in this regard. Ownership concentration (OC) is a point of discussion because it may affect banks’ corporate governance and transparency and disclosures (T&D) issues. This study aims to determine how OC affects the transparency in the banks.Design/methodology/approachA T&D index is built into the study covering all the relevant contemporary issues regarding disclosures in banks. The panel data specification is used to find out the association of components of the OC on the T&D practices in the banks. Bank data of 34 banks are gathered for four years for the study.FindingsIt is found that except for retail investors, other classes of OC are not concerned with the disclosures in the banks even though substantial financial and non-financial interests are at stake concerning them. The study’s findings suggest framing policies and regulations considering the accountability of promoters and institutional investors for ensuring disclosures in banks.Research limitations/implicationsA few proxies to measure T&D found in the literature have not been used in the study. Similarly, the definition of promoter’s class of investors can be improved.Originality/valueTo the best of the authors’ knowledge, no other study builds T&D for banks and examines their impact because of the ownership classes (as used by the current study). This study is unique in this aspect.
Conditional impact of credit growth on macroeconomic and financial aggregates: evidence from Turkey
Authors: Cayirli Omer , Kayalidere Koray , Aktas Huseyin 
Published: June 2022

PurposeThe purpose of this paper is to investigate the impact of changes in credit stock on real and financial indicators in Turkey with a focus on conditional and time-varying dynamics.Design/methodology/approachIn addition to lag-augmented vector autoregression (LA-VAR) based time-varying Granger causality tests, threshold models and a research setting that identifies high/low states of credit growth based on 24-month moving averages are used to explore regime-dependent behavior. For investigating the asymmetric dynamics, the authors use a methodology that identifies good/bad news in credit growth based on 24-month moving averages and standard deviations.FindingsResults strongly suggest that the impact of changes in credit stock induces conditional responses. Moreover, we find evidence for asymmetric responses. In the case of Turkey, efforts to spur growth through credit produce a strong negative byproduct, a depreciation in the exchange rate. The authors also find that changes in credit stock have become more relevant for uncertainties in inflation and exchange rate expectations, particularly in the era after mid-2018 in which credit growth volatility has increased noticeably.Originality/valueThis study provides a comprehensive analysis of time-varying and conditional responses to a change in credit stock in a major emerging economy. Using a moving threshold based only on the available information in the analysis of state-dependency represents a new approach.
Government expenditure–shadow economy nexus: the role of fiscal deficit
Authors: Tran Toan Pham-Khanh , Tran Ngoc Phu , Nguyen Phuc Van , Vo Duc Hong 
Published: June 2022

PurposeThe effects of government expenditure on the shadow economy have been investigated. However, the effect from a moderating factor that affects this relationship has been largely ignored in the existing literature. This paper investigates how fiscal deficit moderates the effects of government expenditure on the shadow economy for 32 Asian countries for the past two decades since 2000.Design/methodology/approachThe authors use various techniques, which allow cross-sectional dependence and slope homogeneity in panel data analysis, to examine this relationship in both the long run and short run. The analysis also considers the marginal effects of government expenditure on the shadow economy at different degrees of fiscal deficits.FindingsEmpirical findings from this paper indicate that an increase in government expenditure and fiscal deficit will increase the shadow economy size. Interestingly, the effects of government expenditure on the shadow economy will intensify with a greater degree of the budget deficit. The authors also find that enhancing economic growth to improve income per capita and extending international trade appears to reduce the shadow economy in the Asian countries.Practical implicationsThe authors consider that policies targeting reducing shadow economy should follow conventional economic policies on economic growth, unemployment and inflation.Originality/valueTo the best of the authors’ knowledge, this is the first empirical study conducted to examine the moderating role of fiscal deficit in the government expenditure–shadow economy nexus in Asian countries.
Formal clusters supporting small firms' internationalization: a case of public–private interaction
Authors: Carloni Elisa 
Published: June 2022

Purpose
This study aims to explore the role played by a formal cluster initiative in supporting small firms' internationalization processes. Taking a public–private interaction perspective, this study aims to understand interaction mechanisms within an internationalization project implemented by a formal cluster initiative.

Design/methodology/approach
This study uses a qualitative approach based on a case study of a Swedish formal cluster initiative involved in an internationalization project. The case is analyzed through the industrial marketing and purchasing approach, relying on the Actors–Resources–Activities (ARA) framework.

Findings
The analysis highlights the role of formal clusters as supporters and “accelerators” of internationalization processes. Based on the ARA framework, the roles of the public and private actors emerge: the cluster plays the role of orchestrator, supporter and financer, while on the businesses' side, participants assumed the role of customers, displaying various degrees of interest and commitment and giving rise to a leader–follower pattern. Activities occurred at multiple levels, interorganizational, intraproject, interprojects, through different timings and typologies. The main resources at stake were the combination of knowledge, complementary capabilities and financial incentives.

Originality/value
This empirical study provides novel empirical evidence and theoretical development over the phenomenon of formal clusters. This study contributes to the current debate on public–private interaction mechanisms and to the upgrading and circulation of international business knowledge.
The impact of the relationship commitment and customer integration on supply chain performance
Authors: Ruzo-Sanmartín Emilio , Abousamra Alaa Abdelaziz , Otero-Neira Carmen , Svensson Göran 
Published: June 2022

Purpose
This study aims to show how to improve supply chain performance through the relationship between firms and their customers. In doing so, this study examines the impact of a firm’s relationship commitment and customer integration on supply chain performance. The aim is to detail a way to increase supply chain performance through the relationship between companies and their customers.

Design/methodology/approach
The empirical analysis was based on a survey on 205 corporate-Egypt multi-industry businesses including manufacturing, retailing, wholesaling and shipping services firms. Data collection was through a questionnaire survey distributed to 1,264 senior managers with responsibilities in the field of supply chain, logistics, purchasing, marketing and operations and with a 16% response rate. A conceptual model was designed, and hypotheses were analysed with covariance-based structural equation modelling.

Findings
This study makes a significant contribution to the supply chain management (SCM) literature by examining the influence of firms’ relationship commitment on supply chain performance in the supply chain management context by means of the disaggregation of customer integration into two dimensions: integration with customer (IWC) and integration by customer (IBC). The findings indicate that firms’ relationship commitment does not relate directly to supply chain performance, but rather indirectly through integration both with and by customers.

Research limitations/implications
This paper outlines a conceptual model in which firms’ relationship commitment relates indirectly to supply chain performance. The model also sheds light on the fact that IWCs precedes IBCs in supply chains. This finding suggests that firms should focus on customer integration to improve supply chain performance.

Practical implications
This study offers a particularly refined understanding of the reasons behind and situations in which supply chain integration (SCI) enables firms to gain superior supply chain performance. In fact, firms focusing on customer integration may improve their supply chain performance, thus enhancing the value of the supply chain.

Originality/value
This study contributes to the literature by considering a relational view of the SCI-Performance path. In particular, by disaggregating customer integration into IWCs and IBCs, this paper verifies customer integration acting as a mediator between relationship commitment and supply chain performance in supply chains.
A systematic review for organizing servitization by multi-actor collaborations: lenses, factors and outcomes
Authors: Wang Jinfeng , Zhang Ke , Lin Kuo-Yi , Feng Lijie 
Published: June 2022

Purpose
Implementing servitization requires collaborative efforts from multiple actors in the business network or ecosystem. A multi-actor perspective is considered valuable for understanding the process of servitization. This study aims to review the contemporary research on organizing servitization by multi-actor collaborations.

Design/methodology/approach
The approach of systematic literature review was used. In total, 90 English-language journal articles published from 2004 to 2021 were selected based on a series of rigorous steps. Furthermore, descriptive and thematic analyses were conducted to answer the predefined review questions.

Findings
The servitization research from the multi-actor collaboration perspective is an infant field yet growing increasingly. An integrative framework was proposed to reveal the extant related studies. In this framework, three typical servitization lenses emphasizing multi-actor collaborations were uncovered. Moreover, six categories of influence factors and possible positive and negative outcomes for this process were identified. Existing knowledge gaps and underlying research directions were also discussed to lay the foundations for future research.

Research limitations/implications
This research has been limited by the usage of single database, rigorous selection criteria by the Academic Journal Guide (AJG 2018) list and exclusion of non-English papers.

Originality/value
To the best of the authors’ knowledge, this study is one of the earliest systematic literature reviews to explore the servitization issues by adopting a multi-actor perspective. The findings can consolidate the knowledge base of servitization and provide implications for the multiple fields of industrial marketing, operational management, information management and service marketing.
Effective business model adaptations in family SMEs in response to the COVID-19 crisis
Authors: Brunelli Sofia , Gjergji Rafaela , Lazzarotti Valentina , Sciascia Salvatore , Visconti Federico 
Published: June 2022

PurposeThe present paper aims at exploring effective business model adaptations in response to unexpected events such as the COVID-19 pandemic.Design/methodology/approachThe authors test the effect of two major business model adaptations, namely changes in the value proposition and changes in the target market, on a sample of 96 family SMEs.FindingsResults show that only changes in the value proposition had a positive and significant impact on performance, helping family SMEs to better confront COVID-19. However, this effect is reduced in the case of target market change.Originality/valueTo the best of the authors’ knowledge, this is the first study to investigate how business model adaptations in family SMEs affect performance in crisis situations.
I never wanted to just sit around smoking cigarettes and drinking coffee
Authors: Voyce Andrew 
Published: June 2022

Purpose
Essay asks questions about people with schizophrenia and recovery.

Design/methodology/approach
The essay is written in an autoethnographic style.

Findings
The purpose of this paper is to portray the actual outcome for a person with schizophrenia, in the context of recovery and the achievement of independence.

Research limitations/implications
Statistics are from review of various sources and are compared with autoethnographic data. The implications are to confirm social exclusion for the cohort of people with schizophrenia.

Practical implications
Practical implications include the recognition of the unusual destinations for those with schizophrenia.

Social implications
Independence is a desirable and much espoused social outcome and yet so few people with schizophrenia are empowered in this way, meaning that they fail to share a social dialogue with many of their fellow citizens.

Originality/value
This essay details a struggle to live up to social norms which are hindered because of a life with schizophrenia.