bluuebunny/crossref_metadata_2025_split huggingface dataset:
The decline in stroke hospitalization due to COVID‐19 is unrelated to COVID‐19 intensity
Authors: Sedova Petra , Kent Julia Anna , Bryndziar Tomas , Jarkovsky Jiri , Tomek Ales , Sramek Martin , Skoda Ondrej , Sramkova Tereza , Pokorová Kateřina , Littnerova Simona , Brown Robert D. , Mikulik Robert 
Published: December 2022

AbstractBackground and PurposeDuring the coronavirus disease 2019 (COVID‐19) pandemic many countries reported a decline in stroke volumes. The aim of this study was to analyze if the decline was related to the intensity of the COVID‐19 pandemic.MethodsThe first pandemic year (1 March 2020 to 28 February 2021) overall and during the three COVID‐19 waves were compared with the preceding year. Volumes of acute ischaemic stroke (AIS), subarachnoid hemorrhage, intracerebral hemorrhage and recanalization treatments (intravenous thrombolysis [IVT] and mechanical thrombectomy [MT]) were obtained from the National Register of Reimbursed Health Services. Door‐to‐needle time, onset‐to‐door time and National Institutes of Health Stroke Scale at admission were obtained from the Registry of Stroke Care Quality.ResultsDuring the pandemic year compared to the preceding year there were 26,453 versus 28,771 stroke admissions, representing an 8.8% decline (p < 0.001). The declines (−10%, −11%, −19%) appeared in COVID‐19 waves (spring 2020, autumn 2020, winter 2021) except for an increase (2%) during summer 2020. Admissions for AIS declined by 10.2% (p < 0.001), whilst hemorrhagic stroke volumes were minimally decreased. The absolute volumes of IVT and MT decreased by 9.4% (p < 0.001) and 5.7% (p = 0.16), respectively. However, the proportions of ischaemic stroke patients receiving IVT (18% vs. 18%; p = 0.72) and MT (6% vs. 6%; p = 0.28) remained unchanged.ConclusionsThere was a decline in stroke admissions, but such decline was not related to COVID‐19 incidence. The frequency of use of recanalization procedures (IVT, MT) and times (onset‐to‐door time, door‐to‐needle time) in AIS were preserved in the Czech Republic during the first year of the pandemic.
A transnational practice between fractured homes: Second‐generation Turkish–German migrants’ experiences of visiting and being visited
Authors: Kılınç Nilay 
Published: December 2022

AbstractThe paper explores the multiple ways in which visits affect the understanding of home for the Turkish–German second generation who have relocated to Turkey. Based on thematic–narrative analysis of 116 life‐story interviews with second‐generation ‘returnees’ in five regions of Turkey, three types of visits are identified: (i) family visits to Turkey whilst growing up in Germany; (ii) visits to Germany after the second generation has ‘returned’ to Turkey; (iii) visits to Turkey by the second generation's Germany‐residing relatives and friends. Each type has different meanings for the visitors and the visited, creating fluid reflections on the meaning of home, which, especially for the second‐generation ‘returnees’, tends to become fractured. Constantly comparing their two home(‐land)s since childhood, they often simultaneously feel both ‘here’ and ‘there’ as a result of changing attachments and a mix of positive and negative experiences in both locales with their families, friends and the dominant others.
RNA viruses alter house dust mite physiology and allergen production with no detected consequences for allergenicity
Authors: Vidal‐Quist José Cristian , Declercq Jozefien , Vanhee Stijn , Lambrecht Bart N , Gómez‐Rial José , Vidal Carmen , Aydogdu Eylem , Rombauts Stephane , Hernández‐Crespo Pedro 
Published: December 2022

AbstractRNA viruses have recently been detected in association with house dust mites, including laboratory cultures, dust samples, and mite‐derived pharmaceuticals used for allergy diagnosis. This study aimed to assess the incidence of viral infection on Dermatophagoides pteronyssinus physiology and on the allergenic performance of extracts derived from its culture. Transcriptional changes between genetically identical control and virus‐infected mite colonies were analysed by RNAseq with the support of a new D. pteronyssinus high‐quality annotated genome (56.8 Mb, 108 scaffolds, N50 = 2.73 Mb, 96.7% BUSCO‐completeness). Extracts of cultures and bodies from both colonies were compared by inspecting major allergen accumulation by enzyme‐linked immunosorbent assay (ELISA), allergen‐related enzymatic activities by specific assays, airway inflammation in a mouse model of allergic asthma, and binding to allergic patient's sera IgE by ImmunoCAP. Viral infection induced a significant transcriptional response, including several immunity and stress‐response genes, and affected the expression of seven allergens, putative isoallergens and allergen orthologs. Major allergens were unaffected except for Der p 23 that was upregulated, increasing ELISA titers up to 29% in infected‐mite extracts. By contrast, serine protease allergens Der p 3, 6 and 9 were downregulated, being trypsin and chymotrypsin enzymatic activities reduced up to 21% in extracts. None of the parameters analysed in our mouse model, nor binding to human IgE were significantly different when comparing control and infected‐mite extracts. Despite the described physiological impact of viral infection on the mites, no significant consequences for the allergenicity of derived extracts or their practical use in allergy diagnosis have been detected.
Receptor‐mediated effects of Δ9‐tetrahydrocannabinol and cannabidiol on the inflammatory response of alveolar macrophages
Authors: Preteroti Matthew W , Traboulsi Hussein , Greiss Patrick , Lapohos Orsolya , Fonseca Gregory J , Eidelman David H , Baglole Carolyn J 
Published: December 2022

AbstractΔ9‐Tetrahydrocannabinol (Δ9‐THC) and cannabidiol (CBD) are cannabinoids found in Cannabis sativa. While research supports cannabinoids reduce inflammation, the consensus surrounding receptor(s)‐mediated effects has yet to be established. Here, we investigated the receptor‐mediated properties of Δ9‐THC and CBD on alveolar macrophages, an important pulmonary immune cell in direct contact with cannabinoids inhaled by cannabis smokers. MH‐S cells, a mouse alveolar macrophage cell line, were exposed to Δ9‐THC and CBD, with and without lipopolysaccharide (LPS). Outcomes included RNA‐sequencing and cytokine analysis. Δ9‐THC and CBD alone did not affect the basal transcriptional response of MH‐S cells. In response to LPS, Δ9‐THC and CBD significantly reduced the expression of numerous proinflammatory cytokines including tumor necrosis factor‐alpha, interleukin (IL)‐1β and IL‐6, an effect that was dependent on CB2. The anti‐inflammatory effects of CBD but not Δ9‐THC were mediated through a reduction in signaling through nuclear factor‐kappa B and extracellular signal‑regulated protein kinase 1/2. These results suggest that CBD and Δ9‐THC have potent immunomodulatory properties in alveolar macrophages, a cell type important in immune homeostasis in the lungs. Further investigation into the effects of cannabinoids on lung immune cells could lead to the identification of therapies that may ameliorate conditions characterized by inflammation.
Symptom management needs of patients with irritable bowel syndrome and concurrent anxiety and/or depression: A qualitative study
Authors: Kamp Kendra J. , Morgan Hailey , Yoo Linda , Munson Sean A. , Heitkemper Margaret M. , Levy Rona L. 
Published: December 2022

AbstractAimsTo understand the experiences and needs of symptom management among individuals with irritable bowel syndrome and concurrent symptoms of anxiety and/or depression.DesignThis study used a qualitative descriptive research design.MethodsIndividuals with a diagnosis of irritable bowel syndrome and concurrent symptoms of anxiety and/or depression participated were recruited through an online ResearchMatch and a listserv. Semi‐structured interviews focused on symptoms and experiences with symptom management interventions conducted from June to August 2020. Interviews were transcribed and data were analysed based on thematic analysis.ResultsTwelve individuals participated in this study; all reported current irritable bowel syndrome and anxiety/depression symptoms. The data analysis cumulated with three themes related to symptom management: (a) irritable bowel syndrome negatively impacts physical and mental well‐being; (b) a trial and error approach to symptom management; and (c) challenges with healthcare professionals supporting symptom management including negative interactions with healthcare professionals and lack of nutritional expertize and support.ConclusionThere is a need for individualized approaches which consider patients' current symptoms of anxiety and depression, previous experiences with the trial‐and‐error process and consideration for intervention delivery methods.ImpactThere is a limited qualitative research focusing on the experiences of individuals with irritable bowel syndrome and concurrent symptoms of anxiety and/or depression. This research highlights the need for individualized approaches to enhance symptom management that acknowledges patients' psychological state and past negative experiences with providers and prior dietary regimens.
A scoping review of interventions seeking to improve aspects of patient–provider relationships involving Black pregnant and post‐partum people
Authors: Alexander Karen , Clary‐Muronda Valerie 
Published: December 2022

AbstractAimsTo provide a map of the evidence related to interventions targeting patient–provider relationships among Black perinatal people.DesignA scoping review of the literature was conducted.Data SourcesThe database search included English language articles within three databases: PubMed, the Cumulative Index for Nursing and Allied Health Literature, and Medline without date restriction on June 15 and16 2022.Review MethodsThis scoping review used the six‐stage process first described by Arksey and O'Malley and recommended by the Joanna Briggs Institute: (1) specify the research question, (2) identify relevant literature, (3) select studies, (4) map out the data, (5) synthesize, and report the results and (6) consult experts. Studies were included if they (1) reported results of intervention studies related to patient–provider interaction, (2) were written in English and (3) were original research. The articles were reviewed with content analysis methodology to categorize and interpret the findings.ResultsStudies included randomized controlled trials (n = 5) and qualitative studies (n = 3) published between 2001 and 2018. Black pregnant people made up more than half of the participants in five of the eight studies (63%). Interventions were divided into three categories: delivery models (n = 4), mHealth risk assessment tools (n = 2) and patient–provider communication tools (n = 2).ConclusionThis study addressed the unknown role of patient–provider relationship interventions in improving the quality of care received by Black perinatal people. Findings suggest that structural and interpersonal components may have the potential to improve outcomes for Black pregnant people but could be further improved if culturally tailored. Further research is urgently needed to address discrimination and stigma in patient–provider relationships. The findings of this study could inform novel intervention development and should drive research.ImpactA scoping review determined that there are no interventions with Black pregnant people which targeted discrimination and bias in patient–provider relationships.No Patient or Public ContributionThe authors did not include stakeholders such as patients, service users, caregivers or members of the public in the development of this scoping review, as it is a work that serves to set the stage for further community‐based work. The results will however be communicated to community members at a planned advisory board in the future.
Preclinical evaluation of semi‐automated laser ablation for pulmonary vein isolation: A comparative study
Authors: Kuroki Kenji , Reddy Vivek Y. , Iwasawa Jin , Kawamura Iwanari , Neuzil Petr , Estabrook Brian , Melsky Gerald , Dukkipati Srinivas R. , Koruth Jacob 
Published: December 2022

AbstractIntroductionVisually‐guided laser balloon ablation (VGLA) currently requires careful manual rotation of the laser to create overlapping lesions. A novel semi‐automated VGLA may reduce ablation times and lesion gaps. We aimed to compare semi‐automated (SA) VGLA to that of manual (MN) VGLA.MethodsAcute: Nine swine underwent right superior pulmonary vein isolation (PVI) using either SA (n = 3, 13–18 W), MN (n = 3, 8.5–12 W), or radiofrequency (RF, n = 3, 25–40 W) and were killed acutely. Chronic: 16 swine, underwent PVI using either SA (n = 8, 15 W) or MN (n = 8, 10 W), and were survived for 1 month before being killed. All hearts were then submitted for pathological evaluation.ResultsAcute: PVI was successful in all 9/9 swine with lesion counts significantly lower in the SA arm (5.3 ± 5.9, 33.7 ± 10.0, and 28.0 ± 4.4 in SA, MN, and RF arms; p = .007 for SA and MN). At necropsy, circumferentiality and transmurality were 98% and 94% in SA, 98% and 80% in MN, and 100% and 100% in RF arms. A single steam pop was noted on sectioning in the SA arm swine and occurred in the high dose (18 W) strategy. Chronic: PVI was acutely successful in 16/16 swine with no difference in PVI durability rates (62.5% vs. 75.0%), lesion transmurality (95.8 ± 17.4% vs.91.9 ± 25.9%), and circumferentiality (95.8 ± 6.6% vs. 94.8 ± 6.3%) between SA and MN arms. Catheter use time and lesion counts were lower in the SA arm compared to the MN arm (11.5 ± 12.7 vs. 21.8 ± 3.8 min, p = .046 and 4.8 ± 3.83 vs. 35.4 ± 4.4, p < .001).ConclusionMotor‐assisted semi‐automated laser balloon ablation can improve upon procedural efficiency by reducing ablation time.
Stains therapy and the risk of all bleeding and intracranial hemorrhage: A meta‐analysis of randomized controlled studies
Authors: Liu Xiong , Zhu Hailan , Zheng Haoxiao , Sun Lichang , Qiu Min , Huang Yuli 
Published: December 2022

AbstractAimsStatins had been used as a cornerstone in the primary and secondary prevention of cardiovascular disease. Widespread attention had been given to the risk of bleeding, especially intracranial hemorrhage (ICH) in patients receiving statins therapy. This study aimed to determine whether statins treatment was associated with the risk of bleeding and ICH in randomized controlled trials (RCTs).Materials and methodsElectronic databases were searched for studies up to September 8, 2022. Articles from RCTs were included in the meta‐analysis if they reported the bleeding events associated with the treatment of statins or placebo/nonstatin treatment. The risk ratios (RR) of total bleeding and ICH were pooled from the number of patients with each outcome in the statins and control groups from the included studies.ResultsTwenty‐nine studies comprising 145,929 individuals (2437 incident bleeding cases) were included in the meta‐analysis. After a median follow‐up duration of 3.65 years, statins treatment was not associated with the risk of all bleeding (RR = 1.03, 95% CI 0.93−1.15). Furthermore, in 26 studies comprising 144,177 participants, after a median follow‐up duration of 3.95 years, statins treatment was not associated with the risk of ICH (RR = 1.05, 95% CI 0.84−1.31). Although in the subgroup analysis with patients with prior stroke, statins treatment showed an increased risk of ICH (RR = 1.47, 95% CI 1.07−2.01), sensitivity analysis showed that the result was unstable, which may be mainly driven by the SPARCL study.ConclusionsStatins therapy is not associated with the risk of all bleeding and ICH. Although a mildly increased risk of ICH in patients with prior stroke is observed, which may be caused by chance finding and warrant further documentation.
Conservatively replacing missing anterior teeth with resin bonded ceramic restorations
Authors: Trushkowsky Richard , Asavanamuang Praewvanit , Khurana Deepakshi , Passaro Larry , Carnazza Guy 
Published: December 2022

AbstractObjectiveThis article describes improvements in materials and adhesion technologies that have facilitated new, minimally invasive treatment for the replacement of missing anterior teeth.Clinical ConsiderationsIn the first of two case reports presented, the treatment of a 13‐year‐old female patient with a missing right lateral mandibular incisor is described. The patient was told she could not have an implant placed until she was 25 years of age and space post orthodontics was inadequate for implant placement. Treatment options included: a provisional removable appliance (flipper), an Essix appliance, or a resin‐bonded one‐wing lithium disilicate bridge with only slight modification to the right central incisor and a lingual wing on the canine. The second case report describes an adult female patient who had an impacted maxillary left canine that could not be pulled into position and wanted a replacement for the missing No. 11. This article demonstrates how the use a two‐abutment bridge consisting of an inlay in the first premolar and a lingual wing with a proximal retention groove and a vertical path of insertion is a viable alternative to an implant or a conventional bridge to replace a maxillary canine with minimal removal of tooth structure.ConclusionWith the advent of new ceramic materials and improved adhesion minimally invasive prosthesis can be fabricated to replace missing teeth in the esthetic zone. Usually, one wing with a zirconia framework is recommended but Lithium disilicate can also be used depending on occlusal forces.Clinical SignificanceResin‐bonded fixed dental prostheses (RBFDPs) can be used on occasion as a viable alternative to implants but case selection and adherence to appropriate adhesive techniques are key to longevity.
Small Bowel CLEansing Assessment and Report (SB‐CLEAR): Standardizing bowel preparation report in capsule endoscopy
Authors: Macedo Silva Vítor , Lima Capela Tiago , Freitas Marta , Sousa Magalhães Rui , Arieira Cátia , Xavier Sofia , Boal Carvalho Pedro , Rosa Bruno , Moreira Maria João , Cotter José 
Published: December 2022

AbstractBackground and aimSmall‐bowel (SB) cleansing is crucial to assess the reliability of capsule endoscopy (CE) findings. However, the presence of multiple grading systems is hampering their use in clinical practice. In 2020, Colon CLeansing Assessment and Report (CC‐CLEAR) was created and validated. We sought to develop and validate a new score for the evaluation of the SB cleansing, adapted from CC‐CLEAR, aiming to standardize CE reporting regarding the quality of preparation.MethodsThe new grading score, SB CLeansing Assessment and Report (SB‐CLEAR), divided the SB into three tertiles, each being scored depending on the percentage of visualized mucosa (0, < 50%; 1, 50%–75%; 2, > 75%; 3, > 90%). The overall classification was a sum of each segment score, graded between excellent, good, and inadequate (0–5). Any segment scoring ≤1 resulted in inadequate overall classification. CE videos were prospectively evaluated by two experienced CE readers blinded to each other.ResultsWe included 52 CEs, 41(78.8%) female, with a mean age of 57.9 ± 17.9 years. Inter‐observer agreement was very strong for each tertile (first: r = 0.863; second: r = 0.865; third: r = 0.861; P < 0.001), which resulted in overall excellent correlation when considering the quality of preparation in all tertiles (r = 0.940; P < 0.001). By applying final classifications of “inadequate,” “good,” and “excellent,” correlation between observers was also very strong (r = 0.875; P < 0.001).ConclusionsSB‐CLEAR is an innovative and reproducible grading score for evaluation of SB preparation quality in CE, with overall excellent inter‐observer agreement. Along with CC‐CLEAR, this may become a valuable tool to uniformize reporting of bowel preparation quality in CE.
A single protective polymorphism in the prion protein blocks cross‐species prion replication in cultured cells
Authors: Arshad Hamza , Patel Zeel , Amano Genki , Li Le yao , Al‐Azzawi Zaid A. M. , Supattapone Surachai , Schmitt‐Ulms Gerold , Watts Joel C. 
Published: December 2022

AbstractThe bank vole (BV) prion protein (PrP) can function as a universal acceptor of prions. However, the molecular details of BVPrP's promiscuity for replicating a diverse range of prion strains remain obscure. To develop a cultured cell paradigm capable of interrogating the unique properties of BVPrP, we generated monoclonal lines of CAD5 cells lacking endogenous PrP but stably expressing either hamster (Ha), mouse (Mo), or BVPrP (M109 or I109 polymorphic variants) and then challenged them with various strains of mouse or hamster prions. Cells expressing BVPrP were susceptible to both mouse and hamster prions, whereas cells expressing MoPrP or HaPrP could only be infected with species‐matched prions. Propagation of mouse and hamster prions in cells expressing BVPrP resulted in strain adaptation in several instances, as evidenced by alterations in conformational stability, glycosylation, susceptibility to anti‐prion small molecules, and the inability of BVPrP‐adapted mouse prion strains to infect cells expressing MoPrP. Interestingly, cells expressing BVPrP containing the G127V prion gene variant, identified in individuals resistant to kuru, were unable to become infected with prions. Moreover, the G127V polymorphic variant impeded the spontaneous aggregation of recombinant BVPrP. These results demonstrate that BVPrP can facilitate cross‐species prion replication in cultured cells and that a single amino acid change can override the prion‐permissive nature of BVPrP. This cellular paradigm will be useful for dissecting the molecular features of BVPrP that allow it to function as a universal prion acceptor.image
The Organizational Impact of Business Model Innovation: Assessing the Person‐Organization Fit
Authors: Menter Matthias , Göcke Lutz , Zeeb Christopher 
Published: December 2022

AbstractStudies on business model innovation (BMI) have largely focused on firm performance, neglecting outcomes of BMI beyond financial performance indicators. Research lacks empirical findings from the internal organizational dynamics following the inherent transformation process induced by BMI. Rooting our analysis in configuration theory, the purpose of this paper is to shed light on the organizational impact of BMI. We employ the person‐organization fit concept and assess (unintentional) changes in the fit relationship subsequent to BMI. Our findings suggest that incremental BMI enhances fit whereas radical BMI decreases it. We further discuss the theoretical and practical implications of our study.