bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipschitz Carnot-Carathéodory Structures and their Limits
Authors: Antonelli Gioacchino , Le Donne Enrico , Nicolussi Golo Sebastiano 
Published: November 2022

AbstractIn this paper we discuss the convergence of distances associated to converging structures of Lipschitz vector fields and continuously varying norms on a smooth manifold. We prove that, under a mild controllability assumption on the limit vector-fields structure, the distances associated to equi-Lipschitz vector-fields structures that converge uniformly on compact subsets, and to norms that converge uniformly on compact subsets, converge locally uniformly to the limit Carnot-Carathéodory distance. In the case in which the limit distance is boundedly compact, we show that the convergence of the distances is uniform on compact sets. We show an example in which the limit distance is not boundedly compact and the convergence is not uniform on compact sets. We discuss several examples in which our convergence result can be applied. Among them, we prove a subFinsler Mitchell’s Theorem with continuously varying norms, and a general convergence result for Carnot-Carathéodory distances associated to subspaces and norms on the Lie algebra of a connected Lie group.
Radiometal-theranostics: the first 20 years*
Authors: Roesch Frank , Martin Marcel 
Published: November 2022

AbstractThis review describes the basic principles of radiometal-theranostics and its dawn based on the development of the positron-emitting 86Y and 86Y-labeled radiopharmaceuticals to quantify biodistribution and dosimetry of 90Y-labeled analogue therapeutics. The nuclear and inorganic development of 86Y (including nuclear and cross section data, irradiation, radiochemical separation and recovery) led to preclinical and clinical evaluation of 86Y-labeled citrate and EDTMP complexes and yielded organ radiation doses in terms of mGy/MBq 90Y. The approach was extended to [86/90Y]Y-DOTA-TOC, yielding again yielded organ radiation doses in terms of mGy/MBq 90Y. The review further discusses the consequences of this early development in terms of further radiometals that were used (68Ga, 177Lu etc.), more chelators that were developed, new biological targets that were addressed (SSTR, PSMA, FAP, etc.) and subsequent generations of radiometal-theranostics that resulted out of that.
Variance reduction for Metropolis–Hastings samplers
Authors: Alexopoulos Angelos , Dellaportas Petros , Titsias Michalis K. 
Published: November 2022

AbstractWe introduce a general framework that constructs estimators with reduced variance for random walk Metropolis and Metropolis-adjusted Langevin algorithms. The resulting estimators require negligible computational cost and are derived in a post-process manner utilising all proposal values of the Metropolis algorithms. Variance reduction is achieved by producing control variates through the approximate solution of the Poisson equation associated with the target density of the Markov chain. The proposed method is based on approximating the target density with a Gaussian and then utilising accurate solutions of the Poisson equation for the Gaussian case. This leads to an estimator that uses two key elements: (1) a control variate from the Poisson equation that contains an intractable expectation under the proposal distribution, (2) a second control variate to reduce the variance of a Monte Carlo estimate of this latter intractable expectation. Simulated data examples are used to illustrate the impressive variance reduction achieved in the Gaussian target case and the corresponding effect when target Gaussianity assumption is violated. Real data examples on Bayesian logistic regression and stochastic volatility models verify that considerable variance reduction is achieved with negligible extra computational cost.
Kapsner Complementation: An Algebraic Take on Kapsner Strong Logics
Authors: Tedder Andrew 
Published: November 2022

AbstractKapsner strong logics, originally studied in the context of connexive logics, are those in which all formulas of the form$$A\rightarrow \lnot A$$A→¬Aor$$\lnot A\rightarrow A$$¬A→Aare unsatisfiable, and in any model at most one of$$A\rightarrow B, A\rightarrow \lnot B$$A→B,A→¬Bis satisfied. In this paper, such logics are studied algebraically by means of algebraic structures in which negation is modeled by an operator$$\lnot $$¬s.t. any elementais incomparable with$$\lnot a$$¬a. A range of properties which are (in)compatible with such operators are studied, and examples are given; finally, the question of which further operators can be added to such structures is broached.
Welche Rahmenbedingungen braucht die Förderung von Kindern mit Lernschwierigkeiten?
Authors: Schmidt Laura Maria 
Published: November 2022

ZusammenfassungDieser Artikel der Zeitschrift Gruppe. Interaktion. Organisation. beschreibt einen organisationssoziologisch fundierten Analyserahmen für die Untersuchung und den Vergleich von Fördersystemen für Lernende mit einer Lese-Rechtschreib-Störung/Lese-Rechtschreib-Schwäche (LRS). Es wird ein Vorgehen beschrieben, mit dem eine wissenschaftlich, bildungspolitisch und schulpraktisch relevante Fragestellung an den Schnittstellen von Organisation, Team und Individuum bearbeitet werden kann. Betroffene benötigen beim Schriftspracherwerb zusätzliche über den Regelunterricht hinausgehende Förderung. Aufgrund der benötigten Individualisierung außerhalb eines sonderpädagogischen Förderbedarfs stellt diese einen Sonderfall inklusiver Praxis dar. Die Unterstützung wird in verschiedenen Ländern sowohl innerhalb als auch alternativ außerhalb der Schule organisiert. Dabei entstehen länderübergreifende Unterschiede in der Trias aus Organisation, professionellen Normen und staatlicher Regulation.
(Wie) Können Weiterbildungsorganisationen die Professionalität ihrer Lehrenden durch professionelle Lerngemeinschaften unterstützen?
Authors: Hahnrath Eva , Herbrechter Dörthe 
Published: November 2022

ZusammenfassungDieser Beitrag der Zeitschrift Gruppe. Interaktion. Organisation. (GIO) rückt das arbeitsplatznahe, auf kollegial-kooperativem Lernen basierende Personalentwicklungskonzept der professionellen Lerngemeinschaften (PLGen) in den Mittelpunkt, das bislang vor allem für die Professionalitätsentwicklung von Lehrkräften in Schulen erprobt und in seiner Wirksamkeit erforscht worden ist. Auch wenn sich die Weiterbildung in Deutschland z. B. gemessen an der Zahl ihrer Organisationen und Beschäftigten inzwischen zum größten Bildungsbereich entwickelt hat, finden solche berufsbegleitenden Personalentwicklungsmaßnahmen „near the job“ bislang noch kaum Anwendung. Dies ist insofern bemerkenswert, als die Lehrenden in der Weiterbildung keine standardisierten Qualifizierungsprogramme durchlaufen und überwiegend frei-/nebenberuflich agieren, so dass Weiterbildungsorganisationen auf ‚ihre‘ Lehrenden formal kaum Einfluss nehmen können, obgleich sie einen erheblichen Beitrag zur Erreichung des Organisationsziels („gute Bildung für Erwachsene“) leisten. Vor diesem Hintergrund exploriert der Beitrag die PLG-Implementierbarkeit aus der Perspektive von Führungskräften und Lehrenden der Weiterbildung, um zum einen das grundsätzliche Implementationsinteresse relevanter Akteure zu explorieren und zum anderen auch feldspezifisches Wissen für die Entwicklung eines PLG-Implementationskonzepts zu generieren. Unsere Analyse basiert auf strukturierten Leitfadeninterviews (N = 23), die wir inhaltsanalytisch deduktiv-induktiv ausgewertet haben. Die Ergebnisse zeigen überwiegend positive Einschätzungen der PLG-Implementierbarkeit in das Feld der Weiterbildung. Zudem weisen sie u. a. auf eine hohe Relevanz kooperationsbezogener Überzeugungen für die grundsätzliche PLG-Beteiligungsmotivation der Lehrenden und auf eine zentrale Schlüsselfunktion der Führungskräfte für die Anregung der PLG-Implementation hin, die abschließend insbesondere mit Blick auf Folgen für die organisationalen Rahmenbedingungen der Zusammenarbeit diskutiert werden.
Mobility Intersections: Gender, Family, Culture and Location in the Gauteng City-Region
Authors: Parker Alexandra , Rubin Margot 
Published: November 2022

Abstract
The morphology of many South African cities has changed little over the last 25 years: with some of the poorest communities still living on the peripheries in informal settlements and old townships. The resulting spatial mismatch, with difficulties of access and mobility, has been recorded and engaged with elsewhere; the day-to-day implications for households and families have been less well-considered. In work that was undertaken between March 2019 and February 2020 using a mixed-method approach that included focus groups, a smartphone mobility app, mapping and qualitative interviews, as well as, the use of other on-line communication platforms such as WhatsApp to gather data, the team looked at the intersection between mobility, access and household dynamics. Results surface and highlight how old spatial planning logics have direct impact on contemporary spatial footprints, mobility patterns and transit choices. Former ‘White’ neighbourhoods, designed to be relatively self-contained and meet the needs of the suburban population, still ensure relatively small spatial footprints that are car-reliant. While those living in older informal settlements and townships still have the burden of long distances to access economic and often educational advancement. Similarly, the historical layout of transport modes continues to affect the day-to-day decisions of modal choice. However, these spatial patterns and historical transit planning are overlaid with gender expectations and gendered divisions of labour—as women continue to carry most of the childcare and domestic responsibilities and men continue to feel the necessity for household income provision. Thus, historical and continued segregation in the city-region intersects with diverse dimensions of race, class and culture to perpetuate widespread gendered mobility patterns in the Gauteng City-Region.
The efficacy and safety of caplacizumab in Japanese patients with immune-mediated thrombotic thrombocytopenic purpura: an open-label phase 2/3 study
Authors: Miyakawa Yoshitaka , Imada Kazunori , Ichikawa Satoshi , Uchiyama Hitoji , Ueda Yasunori , Yonezawa Akihito , Fujitani Shigeki , Ogawa Yoshiyuki , Matsushita Tadashi , Asakura Hidesaku , Nishio Kenji , Suzuki Kodai , Hashimoto Yasuhiro , Murakami Hidenori , Tahara Sayaka , Tanaka Tomoyuki , Matsumoto Masanori 
Published: November 2022

AbstractCaplacizumab is an anti-von Willebrand factor humanized single-variable-domain immunoglobulin fragment whose efficacy and safety in immune-mediated thrombotic thrombocytopenia purpura (iTTP) have been demonstrated in international studies. This prospective, open-label phase 2/3 study evaluated caplacizumab 10 mg administered daily during plasma exchange and for 30 days afterward, in combination with immunosuppressive treatment, in Japanese adults with a clinical diagnosis of iTTP (new or recurrent). The primary endpoint was prevention of iTTP recurrence; key secondary endpoints included time to platelet count response, time to organ damage normalization, and safety. Among 21 treated patients, 1 of 15 (6.7%) evaluable patients developed iTTP recurrence. Median time to normalization was 2.79 days for platelet count and 2.65 days for organ damage markers (n = 15). Treatment-emergent adverse events (TEAEs) were mostly mild to moderate in severity; the most frequently reported caplacizumab-related TEAEs were increased alanine aminotransferase, epistaxis, and gastrointestinal hemorrhage (all in 9.5% of patients). At least one bleeding event was reported in 7 of 21 patients (33%). Caplacizumab was effective in Japanese patients with iTTP, with a low rate of iTTP recurrence, rapid normalization of platelet counts and organ damage markers, and no unexpected TEAEs. Trial registration: ClinicalTrials.gov identifier, NCT04074187.
Cricetodontinae (Rodentia, Mammalia) of the Miocene Tagay fauna (Olkhon Island, Lake Baikal, Eastern Siberia)
Authors: Daxner-Höck Gudrun , Mörs Thomas , López-Guerrero Paloma , Erbajeva Margarita A. 
Published: November 2022

AbstractThe collection of fossil Rodentia from the Miocene Tagay fauna comprises Aplodontidae, Mylagaulidae, Sciuridae, Gliridae, Castoridae, Eomyidae and Cricetodontinae. Represented by three taxa the Cricetodontinae dominate the rodent assemblage of the Tagay fauna. The fossils were collected by wet-screening of test samples along the section Tagay-1 at Tagay Bay of Olkhon Island. Here, we report on the medium-sized Democricetodon cf. lindsayi, the very small Democricetodon sp. and the large Gobicricetodon filippovi. The primitive dental pattern of D. cf. lindsayi and G. filippovi suggest archaic members of the genera, and an age around the Early/Middle Miocene transition.
Economic Ripple Effects of Individual Disasters and Disaster Clusters
Authors: Zhang Zhengtao , Li Ning , Wang Ming , Liu Kai , Huang Chengfang , Zhuang Linmei , Liu Fenggui 
Published: November 2022

AbstractDisaster clusters refer to major disasters that cluster in space and time without any linkage, resulting in large direct damage and economic ripple effects (EREs). However, the cumulative EREs caused by a disaster cluster may not be equal to the summation EREs of the individual disasters within a cluster. We constructed a global economic ripple input-output model suitable for the analysis of disaster clusters and demonstrated the extent of this difference with the example of two typical catastrophes that occurred in 2011 (the Great East Japan Earthquake and the Great Thailand Flood), within an interval of only 136 days. The results indicate that: (1) The EREs suffered by 11 of the 35 countries affected (30%) are “1 + 1 > 2”, and “1 + 1 < 2” for 24 of the 35 countries affected (70%). This indicates that there is a significant difference between the cumulative and the summation losses. The difference is related to factors such as trade distance, economic influence of disaster-affected sectors, and trade ties; (2) The EREs are more than two times the direct loss and have an industrial dependence, mostly aggregated in key sectors with strong industrial influence and fast trade times in the industrial chain; and (3) Additional EREs due to the extension of the recovery period will be aggregated in countries with close trade ties to the disaster-affected country, further magnifying the difference.
Associations Between Cohabitation, Marriage, and Suspected Crime: a Longitudinal Within-Individual Study
Authors: Airaksinen Jaakko , Aaltonen Mikko , Tarkiainen Lasse , Martikainen Pekka , Latvala Antti 
Published: November 2022

Abstract
The effects of marriage on criminal behavior have been studied extensively. As marriages today are typically preceded by cohabiting relationships, there is a growing need to clarify how different relationship types are associated with criminality, and how these effects may be modified by relationship duration, partner’s criminality, and crime type. We used Finnish longitudinal register data and between- and within-individual analyses to examine how cohabitation and marriage were associated with suspected crime. The data included 638,118 residents of Finland aged 0–14 in 2000 and followed for 17 years for a suspected crime: having been suspected of violent, drug, or any crime. Between-individual analyses suggested that those who were cohabiting or married had a 40–65% lower risk of being suspected of a crime compared to those who were single, depending on the type of crime. The within-individual analysis showed a 25–50% lower risk for suspected crime when people were cohabiting or married compared to time periods when they were single. Those in a relationship with a criminal partner had 11 times higher risk for suspected crime than those in a relationship with a non-criminal partner. Forming a cohabiting relationship with a non-criminal partner was associated with reduced criminality. The risk reduction was not fully explained by selection effects due to between-individual differences. Marriage did not introduce further reduction to criminality. Our findings demonstrate that selection effects partly explain the association between relationship status and criminality but are also compatible with a causal effect of cohabitation on reduced risk of being suspected of a crime.
Hydraulic stimulation strategies in enhanced geothermal systems (EGS): a review
Authors: Jia Yunzhong , Tsang Chin-Fu , Hammar Axel , Niemi Auli 
Published: November 2022

AbstractIn enhanced geothermal systems (EGS), the natural permeability of deep rocks is normally not high enough and needs to be increased. Permeability increase can be achieved through various stimulation methods, such as hydraulic, chemical, and thermal stimulation. Among these, hydraulic stimulation is the most commonly used technique to increase both reservoir permeability and the specific area for heat exchange. A comprehensive understanding of the underlying processes towards an optimization of hydraulic stimulation performance while minimizing the potential of unwanted induced seismicity is a critical prerequisite for a successful development of any EGS site. In this paper, we review the hydraulic stimulation strategies that have been developed and implemented for EGS. We begin with a description of the underlying mechanisms through which the permeability and heat exchange area increases are achieved. We then discuss the mechanisms of fluid injection-induced seismicity during and after a hydraulic stimulation operation. After that, alternative hydraulic stimulation strategies, namely conventional hydraulic stimulation, multi-stage fracturing, and cyclic soft stimulation, are reviewed based on current research in theoretical studies as well as, laboratory, and in-situ field experiments. Finally, some representative EGS projects are reviewed, focusing on fluid injection strategies, seismic responses, and reservoir permeability enhancement performance. The review shows the importance and need of (a) a comprehensive geological characterization of the natural fracture system including the nearby fault zones as well as the in-situ stress conditions, prior to the development of the site, (b) a proper design of the well arrangement, such as the positioning of the injection and production wells, and (c) the selection of an appropriate fluid injection strategy for the system at hand.
How the Design of an Organizational Context Helps to Attain Contextual Ambidexterity
Authors: Möller Klaus , Schmid Flavia , Seehofer Theresa Maria , Wenig Philipp 
Published: November 2022

AbstractThis study empirically investigates the relationships of control levers (belief and boundary systems, Simons 1995) and control context (social and performance management context, Gibson and Birkinshaw 2004) with contextual ambidexterity and firm performance. Based on cross-sectional survey data from 198 listed companies in Austria, Germany, and Switzerland, a structural equation model is used to test the hypothesized relationships. We find that the emphasis on formal boundary systems and an informal social context are positively related to contextual ambidexterity, which positively affects firm performance. In contrast, belief systems and performance management context do not influence contextual ambidexterity. Further, we find no support for dynamic tensions, neither between the two control levers nor in the control context.
Genesis of Smectites associated with a Coal Seams Succession in the Neogene Orhaneli and Keles Coal Deposits (Bursa), NW Turkey
Authors: Erkoyun Hülya , Kadir Selahattin , Külah Tacit 
Published: November 2022

AbstractThe Bursa-Orhaneli and Keles-Harmanalan coal deposits were developed in swampy and fluvial-lacustrine environments in western Anatolia under the E–W-trending graben zone during the Neogene. The present study aimed to determine the mineralogical and geochemical properties of clays interlayering the coal seams to define the origin of clay minerals, in particular, smectite. These deposits, comprising argillaceous sediment, marl, coal seam, mudstone, organic-rich shale, and sandstone, were deposited in a lacustrine environment accompanied by volcanogenic materials. The characteristics of sediments and their parent rocks were examined using X-ray diffraction, scanning electron microscopy, energy dispersive spectroscopy, palynology, and chemical analyses. The association of abundant smectite with quartz, amphibole, accessory chlorite, and a decrease in feldspar in fluvial-lacustrine sediments compared to those in the smectite accompanied by feldspar and volcanic glass and the absence of quartz and amphibole in the pyroclastic units suggest that smectite had detrital and authigenic origins. Flaky smectite shows either detrital, irregularly outlined coating and filling pores of terrigenous sediments or in situ precipitation edging resorbed feldspar and devitrified volcanic glass. Chemical analyses of the smectite-rich fraction show montmorillonite compositions with an average structural formula of: (Ca0.42Na0.25K0.08)(Al2.76Fe0.47Mg0.59Ti0.07Mn0.002)(Si7.65Al0.35)O20(OH)4.The positive correlation of Al2O3 vs. TiO2 and K2O vs. Rb may be related to the abundant detrital input. Feldspar and biotite were replaced by illite during diagenesis.An increase in the Ni/Co and V/(V + Ni) ratios in the altered units also suggest oxic, suboxic to anoxic conditions, under the control of a dry, warm to subtropical climate in fresh water and lakes during the Late Eocene to Middle Miocene. The slight enrichment of light rare earth elements (LREE) compared to heavy rare earth elements (HREE) with positive Eu and positive/negative Ce anomalies reflect fractional crystallization of feldspar. The δ18O and δD values of smectite and illite fractions and the wide range of δ34S isotope values (–1.5 to 15‰) for pyrite and chalcopyrite associated with coal indicate a signature of both diagenetic and partial hydrothermal origin.
Mentoring for INnovative Design Solutions (MINDS): Key Design Considerations and Collaborative Teamwork across Universities for Clinical Translation
Authors: Fernandez-Fernandez Alicia , Murfee Walter Lee , LaMack Jeffrey A. , Murray Teresa A. 
Published: November 2022

AbstractThe main purpose of this paper is to share the Mentoring for INnovative Design Solutions (MINDS) Scholars Program developed by Alpha Eta Mu Beta, the International Biomedical Engineering Honor Society. The program’s goals are to (1) introduce biomedical engineering students to an open-ended design experience as part of interuniversity teams with industry and faculty mentors, and (2) develop the ability to create designs considering clinical translatability on teams with different backgrounds and areas of expertise. MINDS uses an experiential learning approach to (1) enrich student curricular experiences through inter-institutional collaboration, (2) build engineering design skills, including three key design considerations for clinical/commercial success: intellectual property protection, regulatory strategy, and market identification; and (3) emphasize the importance of end-user considerations. From 2015 to 2022, MINDS has involved 131 students from 50 universities and 22 faculty and industry mentors. Pre- and post-program surveys show statistically significant improvements in understanding of the design process, regulatory strategy, intellectual property protection, market definition, and key product requirements and features. Students also improved communication and teamwork skills. Many students indicated that MINDS participation made them more likely to choose careers that involve product development and/or entrepreneurship. Students attained a working ability to integrate market needs, regulatory strategy, and intellectual property considerations into the design process. They also further developed soft skills, such as conflict resolution, time management, and effective communication through the challenges of inter-institutional collaboration. Additionally, the program heightened their awareness of how biomedical devices and technologies can benefit society.