bluuebunny/crossref_metadata_2025_split huggingface dataset:
Test of a light emitting diode fully integrated pre-prototype spectrometer for rapid evaluation of table tomato (Solanum lycopersicum L., Marinda F1) quality
Authors: Tugnolo Alessio , Pampuri Alessia , Giovenzana Valentina , Casson Andrea , Guidetti Riccardo , Beghi Roberto 
Published: October 2022

The present research aims to evaluate the performance of an optical pre-prototype based on light emitting diode, (450–860 nm) to quantify table tomatoes’ quality features in a rapid and non-destructive way ( Solanum lycopersicum L., Marinda F1). A total of 200 samples were analysed. Calibration of the pure near infrared (NIR, 960–1650 nm) and visible/near infrared (VIS/NIR, 400–1000 nm) commercial spectrometers to estimate the main tomato quality parameters, i.e. moisture content (MC) and total soluble solids (TSS), was performed by using PLS regression. Since no substantial differences were highlighted between the two commercial devices, to reduce the complexity while keeping the performance of the model using the whole spectra (1647 variables for VIS/NIR), a cost-effective pre-prototype was designed and built by using 12 bands in the VIS/NIR optical range. The pre-prototype shows slightly lower performance, resulting in RMSEP values of 2% and 1.45 °Brix for MC and TSS respectively, compared to RMSEP values of 1% and 1.19 °Brix for the VIS/NIR device (using the entire spectrum). Moreover, no significant differences at 95% were highlighted by using Passing-Bablok regression. In conclusion, the pre-prototype performance can be considered sufficiently accurate to allow an initial field screening of the trend of the analysed parameters (MC and TSS) using a new generation of simplified optical sensors.
Multivariate calibration strategy in simultaneous determination of temperature properties of petroleum diesel by near infrared spectrometry
Authors: Othman Abd Rahim , Zain Sharifuddin Md , Low Kah Hin 
Published: October 2022

It is essential to control the quality of diesel products so that they comply with relevant fuel specifications, however, the quality assessments rely upon conventional wet chemical analyses that are costly and time consuming. Rapid, simultaneous quality measurement enabling immediate online optimisation for process control and blending offers tremendous cost savings by minimising product quality give-away, shipment demurrage, tank inventory, and laboratory analysis. In this study, the use of near infrared spectroscopy and chemometrics demonstrates a straightforward workflow for simultaneous determination of the petroleum diesel’s boiling point at 95% recovery (T95), flash point (FP), cloud point (CP), and cetane index (CI) calibration development. It involved appropriate spectral region selection, calibration/validation set partition, data pre-processing, regression modelling and validation. Based on the calibration and validation results, the supervised learning models that are obtained from a combination region of 4000–4800 cm−1 on a randomly selected calibration set managed to deliver promising predictive performance in terms of coefficient of determination for prediction (r2P/T95 ≥ 0.94, r2P/FP ≥ 0.89, r2P/CP ≥ 0.89, r2P/CI ≥ 0.993), root mean square error of prediction (RMSEP (T95) ≤ 5.2°C, RMSEP (FP) ≤ 2.0°C, RMSEP (CP) ≤ 2.4°C, RMSEP (CI) ≤ 0.3), and ratio of performance deviation (RPD (T95) ≥ 3.7, RPD (FP) ≥ 3.0, RPD (CP) ≥ 2.9, RPD (CI) ≥ 11). Regardless of principal component regression or partial least square regression on either the multiplicative scattering corrected spectra or Savitzky-Golay second derivative spectra, the developed models met respective ASTM reproducibility requirements, and were considered adequate for immediate quality assessment of diesel.
Efficacy of single-shot adductor canal block before Versus after primary total knee arthroplasty – Does timing make a difference? A randomized controlled trial
Authors: Heller Snir , Shemesh Shai , Rukinglaz Oleg , Cohen Nir , Velkes Steven , Fein Shai 
Published: October 2022

Background Total knee arthroplasty (TKA) is associated with severe postoperative pain. Multimodal analgesia, including peripheral nerve block, is recommended for post-operative pain relief. Administration of some pain medications prior to surgery has shown to be more effective than after the operation. This is a prospective, randomized controlled trial designed to compare the analgesic efficacy of the adductor canal block (ACB) performed immediately before or immediately after primary total knee arthroplasty (TKA). We hypothesized that ACB before the surgery will reduce postoperative pain and improve knee function. Methods A total of 50 patients were enrolled and randomized into 2 groups, with 26 patients receiving a preoperative ACB and 24 receiving a postoperative ACB. Results Treatment groups were similar in terms of gender ( p = .83), age ( p = 0.61) weight ( p = .39) and ASA score. Average visual analogue scale (VAS) on arrival to the post-anesthesia care unit (PACU) were 4.9 ± 3.2 in the preoperative ACB versus 3.4 ± 2.8 for the postoperative ACB ( p = .075). VAS scores at different time points as well as the mean, minimal and maximal reported VAS scores were not significantly different between the two groups. The cumulative quantities of Fentanyl administered by the anesthesia team was comparable between the groups. Similarly, the dosage of Morphine, Tramadol, Acetaminophen and Dipyrone showed only small variations. The Quality of Recovery Score, Knee Society Scores and knee range of motion did not differ between the groups. Conclusions Our findings demonstrate no significant differences in patient total narcotics consumption, pain scores and functional scores, between preoperative and postoperative ACB in patients undergoing TKA. Trial Registration The trial was registered at www.clinicaltrials.gov and was assigned the registration number NCT02908711 Level of Evidence level I randomized controlled trial.
Association of Patient-Centered Elements of Care and Palliative Care Among Patients With Advanced Lung Cancer
Authors: Schweiger Liana , Vranas Kelly C. , Furuno Jon P. , Hansen Lissi , Slatore Christopher G. , Sullivan Donald R. 
Published: October 2022

Context Palliative care (PC) is associated with improved quality of life, survival, and decreased healthcare use at the end of life among lung cancer patients. However, the specific elements of palliative care that may contribute to these benefits are unclear. Objectives To evaluate the associations of PC and its setting of delivery with prescriptions of symptom management medications, advance care planning (ACP), hospice enrollment, and home health care (HHC) receipt. Methods Retrospective, cohort study of patients with advanced stage (IIIB/IV) lung cancer in the Veterans Health Administration (VA) diagnosed from 2007-2013; with follow-up through 2017. Propensity score methods were used with inverse probability of treatment weighting and logistic regression modeling, adjusting for patient and tumor characteristics. Results Among 23 142 patients, 57% received PC. Compared to non-receipt of PC, PC in any setting (inpatient or outpatient) was associated with increased prescriptions of pain medications (Adjusted Odds Ratio (aOR) = 1.63, 95% CI: 1.45-1.83), constipation regimen with pain medications (aOR = 2.04, 95% CI: 1.63-2.54), and antidepressants (aOR = 1.78, 95% CI: 1.52-2.09). PC was also associated with increased ACP (aOR = 1.52, 95% CI: 1.37-1.67) and hospice enrollment (aOR = 1.39, 95% CI:1.31-1.47), and decreased HHC (aOR = 0.79, 95% CI: 0.70-.90) compared to non-receipt of PC. Receipt of PC in outpatient settings was associated with increased prescriptions of pain medications (aOR = 2.54, 95% CI: 2.13-3.04) and antidepressants (aOR = 1.76, 95% CI: 1.46-2.12), and hospice enrollment (aOR = 2.09, 95% CI: 1.90-2.31) compared to receipt of PC in inpatient settings. Conclusions PC is associated with increased use of symptom management medications, ACP, and hospice enrollment, especially when delivered in outpatient settings. These elements of care elucidate potential mechanisms for improved outcomes associated with PC and provide a framework for a primary palliative care approach among non-palliative care clinicians.
Inhibitory synaptic loss drives network changes in multiple sclerosis: An ex vivo to in silico translational study
Authors: Huiskamp Marijn , Kiljan Svenja , Kulik Shanna , Witte Maarteen E , Jonkman Laura E , GJM Bol John , Schenk Geert J , Hulst Hanneke E , Tewarie Prejaas , Schoonheim Menno M , Geurts Jeroen JG 
Published: October 2022

Background: Synaptic and neuronal loss contribute to network dysfunction and disability in multiple sclerosis (MS). However, it is unknown whether excitatory or inhibitory synapses and neurons are more vulnerable and how their losses impact network functioning. Objective: To quantify excitatory and inhibitory synapses and neurons and to investigate how synaptic loss affects network functioning through computational modeling. Methods: Using immunofluorescent staining and confocal microscopy, densities of glutamatergic and GABAergic synapses and neurons were compared between post-mortem MS and non-neurological control cases. Then, a corticothalamic biophysical model was employed to study how MS-induced excitatory and inhibitory synaptic loss affect network functioning. Results: In layer VI of normal-appearing MS cortex, excitatory and inhibitory synaptic densities were significantly lower than controls (reductions up to 14.9%), but demyelinated cortex showed larger losses of inhibitory synapses (29%). In our computational model, reducing inhibitory synapses impacted the network most, leading to a disinhibitory increase in neuronal activity and connectivity. Conclusion: In MS, excitatory and inhibitory synaptic losses were observed, predominantly for inhibitory synapses in demyelinated cortex. Inhibitory synaptic loss affected network functioning most, leading to increased neuronal activity and connectivity. As network disinhibition relates to cognitive impairment, inhibitory synaptic loss seems particularly relevant in MS.
A new threshold for kidney asymmetry improves association with abnormal renal-aortic ratio for diagnosis of renal artery stenosis
Authors: Artyszuk Łukasz , Symonides Bartosz , Gaciong Zbigniew , Cienszkowska Katarzyna , Ludwiczak Marta , Wrzaszczyk Maciej , Szmigielski Cezary A 
Published: October 2022

Background: Renal artery stenosis (RAS) reflects more widespread atherosclerosis deposition and is associated with high morbidity and mortality. According to the guidelines, a discrepancy in the size of the kidneys of over 15 mm found in an ultrasound should initiate the RAS diagnostic algorithm. This study aims to find the optimal threshold for renal asymmetry that better reflects the frequency of a significantly abnormal renal-aortic ratio (RAR), justifying further RAS diagnostic workup, than the currently used cut-off of 15 mm difference in renal diameters. Methods: The analysis included 1175 patients (mean age: 52 years, IQR: 38–66, men/women: 597/578) who underwent Doppler ultrasonography screening of renal arteries with recorded kidney size and RAR calculation. Ultrasound features of RAS were defined as a RAR greater than 3.5 or signs of renal artery occlusion. Receiver operating characteristic (ROC) curves were created and analyzed for absolute differences in kidney size and abnormal RAR. We calculated the area under the curve (AUC) and optimal cut-off values for sensitivity and specificity analysis. Results: The final analysis included 169 patients with a significant difference in renal dimension. RAS features were met in 61 patients. According to ROC curve analysis, the optimal index of renal asymmetry was 12 mm. The sensitivity and specificity for this method were 82.0% and 83.3%, respectively, and AUC was 86.3%. Conclusion: Changing the definition of a significant difference in kidney size from 15 mm to 12 mm increases sensitivity and specificity for abnormal RAR and this finding may accelerate the diagnosis of RAS.
Structural design and dynamics optimization for heald frame made by carbon fiber reinforced composites
Authors: Haifei Qiu , Binbin Han , Pengfei Huang , Hongwei Zhang 
Published: October 2022

For improving the performance defects of traditional heald frame, the carbon fiber reinforced composites was applied to technical upgrading of the heald frame. On the basis of the theory analysis of composites laminates, the symmetrical ply scheme suitable for manufacturing of the heald frame in overall laminated was constructed, and a type of parametric program for finite element modeling was developed by ANSYS Parametric Design Language (APDL). The optimal mathematical model of the composites heald frame was proposed, and then the thickness parameter ( t) and direction parameters (α, θ) of fiber layer were dynamic optimized by using of Sub-problem method. The work increased the fundamental frequency (ω1) of the heald frame by 10.38%. Besides, the harmonic response frequency was also increased from 48.41 Hz to 53.77 Hz, which conductive to further improve dynamics properties of the composites heald frame. This paper provides technical guidance for innovative design of new heald frame, and is helpful to solve the problem of speed matching between heald frame and high-speed loom.
Validating Clinical Distal Radioulnar Joint Examination With Radiographic Parameters
Authors: Meaike Jesse D. , Meaike Joshua J. , Amrami Kimberly K. , Kakar Sanjeev 
Published: October 2022

Background: The purpose of this study was to quantify the in vivo displacement of bilateral distal radioulnar joints (DRUJs) in resisted pronosupination. We hypothesize that this will demonstrate no appreciable difference between the left and right DRUJ, thus validating the concept of using the uninjured wrist as a control for physical examination as well as dynamic imaging studies. Methods: Thirty-two participants without a history of wrist pathology underwent a dynamic computed tomography (CT) protocol evaluating bilateral forearm rotation in neutral forearm rotation, 60° pronation, and 60° supination, including maximal isometric muscle loading. The DRUJ alignment, specifically the absolute degree and direction of subluxation of the ulna relative to the sigmoid notch, was then assessed using a modification of the radioulnar line method. Results: There was no significant difference in the mean displacement when comparing the right and left sides in neutral, pronation, or supination. The mean displacement was also compared between male and female patients, and there was no statistically significant difference in absolute displacement in neutral (male 0.99 mm vs female 1.38 mm) or supination (male −0.57 mm vs female −0.23 mm). However, the difference in pronation was statistically significant (male 2.69 mm vs female 3.26 mm). Of the 192 sequences, the measurements of displacement of the authors were within 1 mm 86% of the time (166 of 192). Conclusions: Dynamic CT of bilateral DRUJs in resisted pronation, supination, and neutral demonstrated symmetry between the right and left DRUJ, supporting the concept of using the contralateral side as a control to identify instability in an injured wrist.
Liver fat content assessed by conventional B-mode ultrasound and metabolic profile in non-diabetic patients: Implications for clinical practice
Authors: Villani Rosanna , Magnati Grazia Pia , Tuccari Giulia , Sangineto Moris , Romano Antonino Davide , Cassano Tommaso , Serviddio Gaetano 
Published: October 2022

Introduction: Several studies have demonstrated a positive correlation between severe hepatic steatosis and metabolic alterations; however, few studies have addressed the potential association between different grades of steatosis and clinical patterns in a non-diabetic population. Methods: We conducted a cross-sectional study of 223 non-diabetic individuals. The severity of steatosis was assessed using B-mode ultrasound. We analyzed lipid and glucose profiles according to the severity of hepatic steatosis. Estimated glomerular filtration rate (eGFR) values were also recorded to investigate the potential impact of steatosis on kidney function. Results: Patients with steatosis were found to have higher insulinemia and mean values of fasting plasma glucose compared to patients without steatosis. A significant decrease in high-density lipoprotein level was observed only in patients with severe or moderate steatosis. All grades of steatosis were associated with increased triglyceride levels, which were more significant in severe steatosis. Subgroup analysis by body mass index demonstrated a significant difference between lean patients with steatosis and lean patients without steatosis for triglycerides (p = 0.002) and high-density lipoprotein levels (p = 0.019). Finally, patients diagnosed with steatosis demonstrated a higher prevalence of estimated glomerular filtration rate < 90 ml/min. Conclusion: The degree of steatosis diagnosed at ultrasound may predict glucose or lipid metabolism disorders and a decline in kidney function in a non-diabetic population.
Evaluation of the safety profile of endoscopic pyloromyotomy by G-POEM: a French multicenter study
Authors: Baret Florian , Jacques Jeremie , Pioche Mathieu , Albouys Jeremie , Vitton Véronique , Vanbiervliet Geoffroy , Debourdeau Antoine , Barthet Marc , Gonzalez Jean-Michel 
Published: October 2022

Background: Gastric per oral endoscopic esophageal myotomy (G-POEM) is a promising procedure to treat refractory gastroparesis. The safety profile of G-POEM is an important topic because gastroparesis is a functional pathology, with a procedure whose effectiveness is between 50 and 65% depending on the studies. Objectives: We present this retrospective multicenter study, with the aim of establishing a safety profile, focusing on serious adverse events (AEs). Design: This was a multicenter observational cohort study conducted in five French expert centers. Methods: All patients who underwent G-POEM for refractory gastroparesis between 2015 and 2021 were included for analysis. AEs were classified into per endoscopic, early postoperative, and late postoperative, up to 1 month. Their severity was assessed using Dindo–Clavien and American Society for Gastrointestinal Endoscopy classification. The primary objective was to evaluate the rate of G-POEM severe AEs. Secondary objectives were to document other postoperative AEs, and to identify predictive factors. Results: In all, 217 patients were included: 81 men and 136 women, mean age 52 ± 17 years. The average procedural time was 44 ± 14 min (12–78). The average hospital stay was 3.7 ± 2.3 days. The AEs rate classified as Clavien–Dindo ⩾3 was 0.4% (one delayed bleeding requiring blood transfusion and endoscopic management). There were no deaths or patients admitted to intensive care unit. The rates of mucosotomy and capnoperitoneum were 3.7 and 1.8%, respectively, without clinical consequences. Most patients (81.5%) did not experience any AE. Three cases of dumping syndrome occurred, quickly managed by dietary measures. Conclusion: Our study confirms the safety of G-POEM with less than 0.5% of serious AEs, medically managed. This outcome makes this a procedure to have a good benefit–risk ratio.
Cutting Down Trees Does not Build Prosperity: On the Continued Decoupling of Amazon Deforestation and Economic Development in 21st Century Brazil
Authors: Norris Darren , Sabadini Carvalho Terciane , Guerrero Angela M. , Sobral Escada Maria Isabel , Alencar Ane , Kimbrough Liz , Butler Rhett A. 
Published: October 2022

Background and Aims We present evidence examining spatial and temporal patterns in forest cover changes and economic indicators in Brazilian Amazonia. Specifically, we tested two predictions embedded in arguments used by influential interest groups: (i) indicators of economic progress should increase where there is less forest and (ii) areas with most recent deforestation should have increased economic indicators. Methods Complementary methods assessed annual variation in economic indicators across 794 administrative districts (municipalities) covering 4.9 Mkm2 of the Brazilian Amazon from 2002 to 2019. A representative subset of municipalities was used to compare economic and socioeconomic indicators across municipalities with contrasting forest cover. Results Contrasting results between the full and a representative subset of municipalities suggested that municipality-level economic indicators cannot be directly attributed to the loss of natural forests. There was no association between forest loss and economic (average salary) or socioeconomic indicators (existence of sanitation plans and internet connectivity). The economic indicators of municipalities with less than 40% forest cover in 1986 were no different to that of similar municipalities with more than 60% forest cover from 1986 to 2019. Conclusion The evidence contradicted both predictions tested. Reducing forest cover does not appear to directly promote socioeconomic progress. Any localized associations between forest cover and poverty most likely result from other more plausible alternatives including lack of opportunity and a widespread failure to effectively implement and enforce existing policies within the local socioeconomic context. Implications for Conservation Our findings support evidence from across the tropics that shows deforestation does not necessarily generate transformative and equitable food production systems or lead to poverty alleviation.
Eight Weeks of Pilates Training Improves Respiratory Measures in People With a History of COVID-19: A Preliminary Study
Authors: Bagherzadeh-Rahmani Behnam , Kordi Negin , Haghighi Amir Hossein , Clark Cain C.T. , Brazzi Luca , Marzetti Emanuele , Gentil Paulo 
Published: October 2022

Background: Coronavirus disease 2019 (COVID-19) can result in prolonged and severe damage to the lungs and quality of life (QoL). This study was designed to investigate the effects of 8-week Pilates and Aqua-Pilates training on pulmonary function and QoL in patients with COVID-19. Hypothesis: Pilates and Aqua-Pilates training promotes similar changes on pulmonary function and QoL in people with a history of COVID-19. Study Design: Randomized controlled trial. Level of Evidence: Level 3. Methods: A total of 45 participants (24 men and 21 women) with a history of COVID-19 were assigned randomly to 3 groups: Pilates training (standard Pilates), Aqua-Pilates training (Pilates in water), and Control. The training protocol was performed for 8 weeks (3 sessions per week). Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and the ratio of FEV1 to the FVC (FEV1/FVC) indices were measured by a spirometer. The 26-item questionnaire World Health Organization Quality of Life (WHOQOL) BREF was used to assess QoL. Data were analyzed using paired-sample t test and analysis of covariance with an alpha level <0.05 Results: The mean age of the participants was 49.9 ± 6.4 years. After 8 weeks of Pilates and Aqua-Pilates training, there were significant increases in FVC (21.4% for Pilates and 22.1% for Aqua-Pilates, P < 0.05), FEV1 (32.3% for Pilates and 34.7% for Aqua-Pilates, P < 0.05), and FEV1/FVC% (9% for Pilates and 10.3% for Aqua-Pilates, P < 0.05) for the experimental groups, but not for control. Changes for Pilates and Acqua-Pilates were significantly higher than for control. The QoL scores were significantly different within and between the experimental groups, with greater improvements in the Aqua Pilates group than in the Pilates group. Conclusion: An 8-week Pilates or Aqua-Pilates training can improve pulmonary function as much as 34%, depending on the parameter, and QoL in people with a history of COVID-19. Aqua-Pilates training appears to be preferable to standard Pilates. Clinical Relevance: The findings provide important insights into how healthcare professionals can prescribe exercise for COVID-19 survivors.