bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of eye injury on the child's academic success and social inclusion level: a case-crossover study
Authors: Jovanovic Nina , Peek-Asa Corinne , Ling Zhang , Cavanaugh Joe E , Begagic Emir , Alajbegovic-Halimic Jasmina 
Published: May 2022

Abstract
Purpose: To investigate the association between an eye injury and later academic performance as well as the level of social engagement.Method: A case-crossover study was used to investigate any changes in academic success and social inclusion before and after an injury. Eligibility criteria included all severe injuries admitted during 2011-2017 period at the main regional clinic. Parents/caregivers were surveyed during 2018-2019 asking questions on academic performance, level of community or social involvement. Results. The total sample for assessing social inclusion and academic success were 36 and 25 children, respectively. In the following academic year's kappa agreements decreased from 0.88 (p-value <0.001) comparing pre-injury with one-year post to 0.5106 (p-value <.0001) in the second year and 0.4750 (p-value=0.003) in the third, suggesting the deteriorating trend of academic success with subsequent years. Comparing academic success before an injury to two years and three years after the injury, p-values in the Wilcoxon signed-rank test were significant (p=0.005706, and 0.003328, respectively) showing the worsening trend with time. The Fisher score showed a significant association only between final visual acuity and levels of social inclusion after an injury. Using the Wilcoxon signed-rank test and the kappa results suggested no association between an eye injury and social inclusion.Conclusion: Our findings suggest no association between social inclusion and eye trauma, while in later years academic success may be more impacted by the eye injury. Due to their unpredictability in childhood age a supportive and sensitive climate at home and school is essential to minimize deleterious responses to eye trauma.
Predicting Diagnostic Gene Biomarkers Associated with Ferroptosis in Psoriasis
Authors: Yang Juan , Liu Qing , Lu Xiuyi , Wen Liuyan , Yuan Shaoping , Wu Weiqi 
Published: May 2022

Abstract
Background: Psoriasis is a prevalent, chronic, and recurrent inflammatory disorder, and new research reveals that ferroptosis plays a role in the pathogenic process. Methods: Two microarray datasets (GSE6710 and GSE83582) about psoriasis were collected from the GEO database, and the ferroptosis-related genes were extracted from FerrDb. Enrichment scores associated with ferroptosis were obtained using gene set enrichment analysis (GSEA) and gene set variation analysis (GSVA) in two microarray datasets, and weighted gene co-expression network analysis (WGCNA) was used to identify ferroptosis-associated module genes in psoriasis, and took the intersection of the key modules. Next, the protein-protein interaction (PPI) and Gene Ontology (GO) pathway enrichment analyses, as well as the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment studies, were performed. The hub genes were identified using Cytoscape with CytoHubba, and a receiver operator characteristic (ROC) curve was utilized to discriminate psoriasis from controls. Results: Ferroptosis-related hub genes in psoriasis (CXCL8, STAT3 and STAT1) were ultimately discovered, and they were able to discriminate psoriasis from controls. The AUC (area under the ROC curve) was above 0.75. To confirm that CXCL8, STAT1, and STAT3 could effectively differentiate psoriasis from controls, the diagnostic value was further validated in the GSE30999, GSE13355, and GSE78097 datasets. Three hub genes had AUC values that were also above 0.75 in three external datasets. Conclusions: We discovered three hub genes (CXCL8, STAT1, and STAT3) that are linked to ferroptosis in psoriasis and can distinguish psoriasis from controls. As a result, CXCL8, STAT1, and STAT3 might be used as ferroptosis-associated biomarkers for disease diagnosis and treatment monitoring.
Prognosis and immune infiltration analysis of SASP-related genes in bladder cancer
Authors: Wang YAXuan , Wang Xiaolin , Zhu HaiXia , Zhang Kun 
Published: May 2022

Abstract
Background: Bladder Urothelial Carcinoma(BLCA) is one of the most common tumors of the male urinary system. It is highly heterogeneous and there is still a lack of biomarkers to predict prognosis in patients with advanced BLCA. senescence-associated secretory phenotype (SASP) plays an important role in tumor and many studies have shown that it is closely related to the immune microenvironment. The aim of this study was to investigate the prognostic value of SASP-related genes and BLCA immune infiltration. Results: There were significant differences in the expression of SASP-related genes in BLCA. Functional enrichment analysis revealed that the 18 SASP-related genes were mainly related to the “HIF−1 signaling pathway”，“PI3K−Akt signaling pathway”，“IL−17 signaling pathway”. A SASP-related gene signature stratifying patients into 2 risk score groups was established based on the TCGA cohort, Patients with higher risk scores had worse overall survival. In addition, we also found that SASP-related genes were closely related to immune cell infiltration.Conclusions: In conclusion, our study confirms the influence of SASP-related genes in BLCA on the prognostic value and immune microenvironment. This will provide important evidence for future research on the role of SASP in BLCA.
Temperature Rise due to Pedestrian Winds and Mitigation Based on Aerodynamic Structural Modification
Authors: Jena Siddharth , Gairola Ajay , Cao Shuyang 
Published: May 2022

Abstract
The urban heat islands have led to several studies on the contribution of urban planning on local temperature rise. But the impact of pedestrian winds due to high-rise buildings and the related rise of temperature due to the venturi effect (increased wind speed through pedestrian channels) have not been investigated. The temperature rise due to pedestrian winds reducing comfort levels and also creating low-pressure regions at ground level, causing accumulation of pollutants. Several researches cited in the paper have studied wind loads and vortex shedding due to pedestrian winds. We have attempted to expand the scope of study to model the non-linear relationship between wind speed and temperature rise in a pedestrian channel and its relevant effect on human comfort. The adverse effect on nearby smaller buildings due to unanticipated downwash has also been studied. The model is validated using Large Eddy Simulation (LES) for the same boundary and wall conditions. Further, the influence has been investigated by corner modification and changing the height to width ratio of the high rise building and feasible solutions have been provided. Such consideration in downwash has not been taken into consideration for interfering with the low-rise building.
LTPConstraint: a transfer learning based end-to-end method for RNA secondary structure prediction
Authors: Fei Yinchao , Zhang Hao , Wang Yili , Liu Zhen , Liu Yuanning 
Published: May 2022

Abstract
Background: RNA secondary structure is very important for deciphering cell’s activity and disease occurrence. The first method which was used by the academics to predict this structure is biological experiment, But this method is too expensive, causing the promotion to be affected. Then, computing methods emerged, which has good efficiency and low cost. However, the accuracy of computing methods are not satisfactory. Many machine learning methods have also been applied to this area, but the accuracy has not improved significantly. Deep learning has matured and achieves great success in many areas such as computer vision and natural language processing. It uses neural network which is a kind of structure that has good functionality and versatility, but its effect is highly correlated with the quantity and quality of the data. At present, there is no model with high accuracy, low data dependence and high convenience in predicting RNA secondary structure. Results: This paper designs a neural network called LTPConstraint to predict RNA secondary structure. The network is based on many network structure such as Bidirectional LSTM, Transformer and generator. It also uses transfer learning to train modelso that the data dependence can be reduced. Conclusions: LTPConstraint has achieved high accuracy in RNA secondary structure prediction. Compared with the previous methods, the accuracy improves obviously both in predicting the structure with pseudoknot and the structure without pseudoknot. At the same time, LTPConstraint is easy to operate and can achieve result very quickly.
Results: This paper designs a neural network called LTPConstraint to predict RNA secondary structure. The network is based on many network structure such as Bidirectional LSTM, Transformer and generator. It also uses transfer learning to train modelso that the data dependence can be reduced.
Conclusions: LTPConstraint has achieved high accuracy in RNA secondary structure prediction. Compared with the previous methods, the accuracy improves obviously both in predicting the structure with pseudoknot and the structure without pseudoknot. At the same time, LTPConstraint is easy to operate and can achieve result very quickly.
Online Fault Detection in Industrial Production Systems based on a Regularized LSTM Autoencoder
Authors: Windmann Stefan , Westerhold Tim 
Published: May 2022

Abstract
In this paper, an LSTM autoencoder approach for online fault detection in industrial production systems is proposed. The presented LSTM autoencoder is used as a stochastic process model, which captures the normal behavior of a production system and allows to predict the probability distribution of sensor data. Discrepancies between the observed sensor data and the predicted probability density distribution are detected as potential faults. The approach combines the advantages of LSTMs and autoencoders: The correlations between individual sensor signals are exploited by an autoencoder, while the temporal dependencies are captured by LSTM neurons. A key challenge in training such a process model from historical data is to control the amount of information passed through the latent space of the autoencoder. Different regularization methods are investigated for this purpose. Fault detection with the proposed LSTM autoencoder has been evaluated on the use case of an industrial penicillin production, achieving significantly improved results in comparison to the baseline LSTM.
Trace Amount of Water Boosting Highly Selective Coupling of Methane to Ethane via a Noble-Metal Free Ni2+-doped MgO/Al2O3 Photocatalyst
Authors: Song Yu-Fei , Shen Tianyang , Bai Ya , Wang Zelin , Sun Xiaoliang , Liu Guihao , Bai Sha , Li Jiaxin , Zheng Lirong 
Published: May 2022

Abstract
Direct and selective coupling of methane into high-value added products under mild conditions is a grand challenge since the activation of the inert C-H bonds (439 kJ mol− 1) and the inhibition of over-oxidation are simultaneously required. Herein, we report the fabrication of a noble-metal free Ni2+-doped MgO/Al2O3 photocatalyst (NiMgAl-x, x represents calcination temperature) through facile topotactic conversion of the corresponding NiMgAl-layered double hydroxides (denoted as NiMgAl-LDH). EXAFS spectroscopy demonstrates that for NiMgAl-x, the Ni2+ ions are isomorphically doped into MgO cell and no NiO phase is formed. By involving trace amounts of water, photo-oxidation of methane to ethane can be accomplished by using NiMgAl-800 as catalyst in a flow reactor with a high production rate (454.30 µmol g− 1 h− 1) and a superior selectivity (97.8%), which was the highest yield among all the noble-metal free photocatalysts reported so far. Detailed characterizations reveal the electron-enriched surface oxygens of NiMgAl-800 generated during the topotatic process lead to the enhanced photocatalytic activity. In-situ DRIFT experiments and DFT calculations show that the introduced H2O molecules can modulate the Gibbs free energy of ŸCH3 towards a coupling conductive pathway instead of production of CO2, resulting in an increased C2H6 selectivity and inhibited CO2 production.
Mast Cell Stabilization: New Mechanism Underlying the Therapeutic Effect of Intense Pulsed Light on Rosacea
Authors: 姜 Peiyu , Liu Yunyi , Zhang Jiawen , Liu Yixuan , Li Min , Tao Meng , Zhang Yue , Tang Zongxiang , Liu Wentao , Xu Yang 
Published: May 2022

Abstract
Background: Rosacea, a chronic inflammatory disorder of the facial skin, is effectively treated by intense pulsed light (IPL). Objective: To explore the potential molecular mechanism underlying the photobiomodulation effect of IPL for rosacea treatment.Methods: Skin samples from patients with rosacea were subjected to histological and immunohistological staining. Ten patients were followed up after IPL treatment using the VISIA® skin analysis system, and the severity was assessed. In vivo, skin changes in mice with rosacea-like inflammation induced by intradermal injection of 320 μM LL-37 with or without IPL treatment were evaluated using L*a*b colorimetry as well as histological and immunological staining. In vitro, LL-37-stimulated mast cells (MCs) with or without IPL treatment were evaluated for protein expression of matrix metalloproteinase (MMP)-9, kallikrein-related peptidase 5 (KLK5), and cathelicidin using western blotting and qRT-PCR.Results: Profound infiltration of inflammatory cells and evident MC degranulation were found in rosacea skin lesions. The expression of rosacea-related biomarkers and inflammatory cytokines was higher in lesion areas than in non-lesional areas, as demonstrated via immunochemical staining. In all patients, rosacea severity reduced after IPL therapy. In vivo, IPL alleviated inflammation in mice with rosacea-like inflammation, as demonstrated by the significantly decreased MMP-9, KLK5, and cathelicidin expression and reduced percentage of degranulating MCs. In vitro, IPL decreased MMP-9, KLK5, and cathelicidin expression in P815 cells, reducing the release of inflammatory cytokines and inhibiting rosacea-like inflammatory reactions. Conclusion: The photobiomodulation effect of IPL for rosacea treatment may inhibit MC degranulation and alleviate inflammatory reactions.
Stereotactic radiosurgery for the treatment of brainstem metastases: a multicenter retrospective study
Authors: Nicosia Luca , Navarria Piera , Pinzi Valentina , Giraffa Martina , Russo Ivana , Tini Paolo , Giaj-Levra Niccolò , Alongi Filippo , Minniti Giuseppe 
Published: May 2022

Abstract
Background: brainstem metastases (BSM) is a rare site of occurrence and their management is a challenging issue. Based on the lack of evidences, the optimal radiation treatment of BSM remains controversial. We evaluated the efficacy and toxicity of linear accelerator (linac)-based stereotactic radiosurgery (SRS) and steretotactic radiotherapy (SRT) in the treatment of BMS in a series of patients treated in different centers. Methods: we conducted a multicentric retrospective study of patients affected by 1-2 BSM from different solid who underwent SRS/SRT. Freedom from local progression (FLP), cancer-specific survival (CSS), overall survival (OS), and toxicity were evaluated. Moreover, predictive factors of treatment response and survival were evaluated.Results: Between 2008 and 2021, 105 patients with 111 BMS received SRS or SRT for 1-2 BSM. Median follow-up time was 10 months (range 3-130). One-year FLP rate was 90.4%. At the univariate analysis, tumor volume ≤0.4 cc and concomitant target therapy were associated with longer FLP, with concomitant target therapy that remained a significant independent predictor [0.058, HR 0.139 (95% CI 0.0182-1.064]. Median OS and CSS were 11 months and 14.6 months, respectively. At multivariate analysis, concomitant target therapy administration was significantly associated with longer OS [HR 0.514 (95%CI 0.302-0.875); p=0.01]. Neurological death occurred in 30.4% of patients, although this was due to BSM progression in only 3 (2.8%) patients. Conclusion: brainstem metastases can be safely treated with linac-based SRS with apparent no detrimental effect on survival. When treated with ablative intent, BSM are an uncommon cause of neurological death. Future prospective trial should answer the question of whether BSM should be excluded a priori from clinical trial.
The use of Heliox plasma to improve the adhesion of a self-adhesive resin cement to NaOCl treated dentin
Authors: Prado Maíra , Telles Iris Sol , de Lima Carolina Oliveira , Silva Emmanuel João Nogueira Leal da , Marques Juliana das Neves , Maia Lucianne , Simão Renata 
Published: May 2022

Abstract
Objectives To evaluate the influence of Heliox plasma to improve the adhesion of self-adhesive resin cement to sodium hypochlorite (NaOCl) treated dentin, in comparison to antioxidant agents, for fiber post cementation. Material and Methods 88 bovine teeth were selected and were cut producing 7mm samples. 65 roots canals were enlarged and assigned to five groups (n=13) according to the treatments, for 1 minute, as follows: control (distilled water); NaOCl (immersed in 5.25% NaOCl for 20 minutes); plasma (after NaOCl immersion, premixed helium and oxygen plasma were applied); sodium thiosulfate (ST) and ascorbate (SA) (after NaOCl immersion, the samples were immersed in 5% ST or 10% SA, respectively). Fiberglass posts were cemented and submitted to the push-out bond strength (POBS) in 10 of 13 samples from each group. Three samples were analyzed by scanning electron microscopy (SEM). Flat dentin surfaces were obtained from the 23 remaining roots and used for measuring surface energy. Results POBS values were ranked as: SA>plasma>ST=control>NaOCl. The ascorbate and plasma groups showed some smear layer removal by SEM. Surface energy was ranked as: control<NaOCl=ST <SA<plasma. Heliox plasma and antioxidant agents restored the POBS of NaOCl-treated dentin. Conclusion The use of Heliox plasma or antioxidant agents for 1 minute improved the adhesion of fiberglass post to dentin using RelyX U200. Clinical Relevance Heliox plasma and antioxidant agents restored bond strength of treated dentin.
Evaluation of diurnal and postural intracranial pressure employing telemetric monitoring in idiopathic intracranial hypertension
Authors: Mitchell James L , Buckham Rebecca , Lyons Hannah , Walker Jessica K , Yiangou Andreas , Sassani Matilde , Thaller Mark , Grech Olivia , Alimajstorovic Zerin , Julher Marianne , Tsermoulas Georgios , Brock Kristian , Mollan Susan P , Sinclair Alexandra J 
Published: May 2022

Abstract
Objectives:Intracranial pressure (ICP) has been thought to vary diurnally. This study evaluates diurnal ICP measurements and quantifies changes in ICP occurring with changes in body posture in active idiopathic intracranial hypertension (IIH). Methods:This prospective observational study utilized telemetric ICP monitoring in people with active IIH. Participants had the Raumedic p-Tel ICP intraparenchymal device (Raumedic, Hembrechts, Germany) surgically inserted. Changes in ICP in the supine position were evaluated. Then, the ICP was measured in the standing, sitting, supine, left lateral decubitus positions and with coughing and bending. Ultimately, changes in ICP over the course of 24 hours were recorded. ISRCTN registration number 12678718.Results:15 women were included, mean (standard deviation) age 29.5 (9.5) years, body mass index 38.1 (6.2) kg/m2, and baseline ICP of 21.2 (4.8) mmHg (equivalent to 28.8 (6.5) cmCSF). ICP rose with the duration in the supine position 1.2 (3.3) mmHg over 5-minutes (p=0.175), 3.5 (2.8) mmHg over 30-minutes (p=0.0002) and by a further 2.1 (2.2) mmHg over 3 hours (p=0.042). Mean ICP decreased by 51% when moving from the supine position to standing (21.2 (4.8) mmHg to 10.3 (3.7) mmHg respectively, p=0.0001). Mean ICP increased by 13% moving from supine to the left lateral decubitus position (21.2 (4.8) mmHg to 24.0 (3.8) mmHg, p=0.028). There was no significant difference in ICP measurements at any point during the daytime, or between 5-minute standing or supine recordings and prolonged ambulatory daytime and end of night supine recordings respectively. ICP increased progressively in conjunction with lying supine position from 23:00hrs to 07:00hrs by 34% (5.2 (1.9) mmHg, p=0.026).Conclusion:This analysis demonstrated that ICP does not appear to have a diurnal variation in IIH, but varies by position and duration in that position. ICP rose at night whilst the patient was continuously supine. Furthermore, brief standing and supine ICP measures in the day predicted daytime prolonged ambulatory measures and end of night peak ICP respectively. This knowledge gives reassurance that ICP can be accurately measured and compared at any time of day in an ambulant IIH patient. These are useful findings to inform clinical measurements and in the interpretation of ICP analyses in IIH.TRIAL REGISTRATION: ISTCRN (12678718).
PLA-lignin nanofibers as antioxidant biomaterials for cartilage regeneration and osteoarthritis treatment
Authors: Liang Ruiming , Yang Xingchen , Yew Pek Yin Michelle , Sugiarto Sigit , Zhu Qiang , Zhao Jinmin , Loh Xian Jun , Zheng Li , Kai Dan 
Published: May 2022

Abstract
BackgroundOsteoarthritis (OA) is common musculoskeletal disorders associated with overgeneration of free radicals, and it causes joint pain, inflammation, and cartilage degradation. Lignin as a natural antioxidant biopolymer has shown its great potential for biomedical applications. In this work, we developed a series of lignin-based nanofibers as antioxidative scaffolds for cartilage tissue engineering.ResultsThe nanofibers were engineered by grafting poly(lactic acid) (PLA) into lignin via ring-opening polymerization and followed by electrospinning. Varying the lignin content in the system was able to adjust the physiochemical properties of the resulting nanofibers, including fiber diameters, mechanical and viscoelastic properties, and antioxidant activity. In vitro study demonstrated that the PLA-lignin nanofibers could protect bone marrow-derived mesenchymal stem/stromal cells (BMSCs) from oxidative stress and promote the chondrogenic differentiation. Moreover, the animal study showed that the lignin nanofibers could promote cartilage regeneration and repair cartilage defects within 6 weeks of implantation.Conclusion Our study indicated that lignin-based nanofibers could serve as an antioxidant tissue engineering scaffold and facilitate the cartilage regrowth for OA treatment.
Tet2-mediated DNA demethylation regulates the proliferation and apoptosis of human leukemia K562 cells
Authors: Qiao Qian , Zhou Yanhua , Yang Honglan , He Zhixu , Fan Anran 
Published: May 2022

Abstract
Tet2 is one member of TET protein family which is responsible for active DNA demethylation, and mutations of Tet2 frequently lead to hematological malignancies. However, the relationship between Tet2-mediated demethylation and the occurrence of hematological malignancies is unclear. Human leukemia K562 cell line was an immortalized leukemia line that of served as an in vitro model of erythroleukemia. In this study, we investigated the effect of Tet2-mediated demethylation on apoptosis and proliferation of human leukemia K562 cells, and found that knockdown of Tet2 promoted the proliferation and inhibited the apoptosis of K562 cells, while enhancement of enzymic activity of TET2 with α-KG inhibited the proliferation and promoted apoptosis of K562. Therefore, Tet2 gene act as a potential target for the treatment of leukemia and small molecules that targeting for Tet2 gene may be used to screen for anti-tumor drugs in hematological malignancies.