bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and immunological characteristics of Aspergillus fumigatus-sensitized asthma and allergic bronchopulmonary aspergillosis
Authors: Chen Hao , Zhang Xinyu , Zhu Li , An Nairui , Jiang Qing , Yang Yaqi , Ma Dongxia , Yang Lin , Zhu Rongfei 
Published: August 2022

BackgroundAspergillus fumigatus (A.f) is a common airborne allergen that contributes to allergic asthma. In some patients, A.f can colonize in the airway and lead to allergic bronchopulmonary aspergillosis (ABPA). However, our understanding of the pathogenesis of A.f-sensitized asthma and ABPA remains inadequate.ObjectiveWe aimed to investigate the clinical and immunological characteristics of A.f-sensitized asthma and ABPA.MethodsA total of 64 ABPA and 57 A.f-sensitized asthma patients were enrolled in the study, and 33 non-A.f-sensitized asthma patients served as the control group. The clinical and immunological parameters included lung function, fractional exhaled nitric oxide (FeNO), induced sputum and blood cell analysis, specific IgE/IgG/IgA of A.f and its components, cytokines (IL-33, IL-25, and TSLP) and CD4+T cell subsets.ResultsThe eosinophils in blood, induced sputum, and FeNO were significantly higher in ABPA patients compared to that in A.f-sensitized patients. The combination of FeNO and eosinophils (EO) parameters presented good diagnostic efficiency in differentiating A.f (+) asthma from ABPA, with a sensitivity of 80% and a specificity of 100%. Specific IgE, IgG, and IgA against A.f also increased in ABPA patients. However, serum IL-25, IL-33, and TSLP showed no significant differences between the two groups. Cell analysis showed an increase in IFN-γ+Th1 cells in the ABPA patients. FlowSOM analysis further confirmed that the frequency of CD3+CD4+PD-1+CD127+IFN-γ+T cells was higher in ABPA patients.ConclusionOur findings suggest the distinct humoral and cell immunological responses in A.f-sensitized asthma and ABPA patients. ABPA patients have more severe eosinophilic inflammation and enhanced Th1 responses compared with A.f-sensitized asthma patients.
Parents' reasons to vaccinate their children aged 5–11 years against COVID-19 in Italy
Authors: Napoli Annalisa , Miraglia del Giudice Grazia , Corea Francesco , Folcarelli Lucio , Angelillo Italo Francesco 
Published: August 2022

ObjectivesThe aims of this cross-sectional study were to investigate why parents decide to vaccinate, as well as the determinants, their children aged 5–11 years against COVID-19 in Italy.MethodsThe survey was conducted from January through May 2022. All parents/guardians who came in randomly selected days to immunization centers for the administration of the first dose of the COVID-19 vaccine to their child were asked to complete a questionnaire about socio-demographic characteristics, attitudes toward COVID-19 infection and vaccination, reason(s) regarding their decision to vaccinate their child, and source(s) of information.ResultsA total of 358 questionnaires were collected. Parent's perception that COVID-19 is a severe illness for the child, assessed using a 10-point Likert scale, was 7.5. The overall mean scores of the risk perception for their child of having the COVID-19 before and after the vaccination were 8.1 and 6.3. A significantly higher parents' level of risk perception for their child of having the COVID-19 after the vaccination has been observed among those not having a university degree, those with the child having at least one chronic medical condition, and those who perceived that COVID-19 is a severe illness for the child. The mean value of respondent trust in the information provided by the pediatricians on a 10-point scale Likert type was 7.6. Female, not having a university degree, higher perception that COVID-19 is a severe disease, not having received information about the vaccination from pediatricians, and needing information had a significantly higher concern of side effects after the vaccination. The most common reasons for vaccinating their children included wanting to protect the child against COVID-19, to attend the school with less risk, to prevent the transmission to family members, and to practice sport and other activities with less risks. Participants with a university degree were more likely to have vaccinated their child for attending the school and practicing sport and other activities with less risks.ConclusionsMore publicity should be promoted among parents of children aged 5–11 years which would increase the coverage rates and thus lower the transmission of SARS-CoV-2 and reduce the occurrence of COVID-19.
Effect of Moxibustion Treatment on Degree Centrality in Patients With Mild Cognitive Impairment: A Resting-State Functional Magnetic Resonance Imaging Study
Authors: Xu Ke , Wei Yichen , Liu Chengxiang , Zhao Lihua , Geng Bowen , Mai Wei , Zhang Shuming , Liang Lingyan , Zeng Xiao , Deng Demao , Liu Peng 
Published: August 2022

BackgroundMild cognitive impairment (MCI) is a common neurological disorder. Moxibustion has been shown to be effective in treating MCI, but its therapeutic mechanisms still remain unclear. This study mainly aimed to investigate the modulation effect of moxibustion treatment for patients with MCI by functional magnetic resonance imaging (fMRI).MethodsA total of 47 patients with MCI and 30 healthy controls (HCs) participated in resting-state fMRI imaging (rs-fMRI) scans. Patients with MCI were randomly divided into true moxibustion group (TRUE, n = 30) and sham moxibustion group (SHAM, n = 17). The degree centrality (DC) approach was applied to distinguish altered brain functions. Correlation analysis was then performed to examine the relationships between the neuroimaging findings and clinical symptoms.ResultsCompared with HCs, patients with MCI mainly showed decreased DC in the left middle frontal cortex (MFC) and bilateral middle cingulate cortex (MCC). After moxibustion treatment, the SHAM group had no significant DC findings, while TRUE group mainly showed significant increased DC in the bilateral MFC and MCC, as well as decreased DC in the left middle occipital cortex (MOC). Repeated measures analysis of variance (ANOVA) showed significant interactions between the two groups of patients with MCI. In addition, the higher Mini-Mental State Examination (MMSE) score was significantly positively correlated with increased DC in the right MFC and left MCC after moxibustion treatment.ConclusionOur findings demonstrate that the potential value of moxibustion treatment on MCI, which adds new insights into the popular view that moxibustion treatment may slow cognitive decline in patients with MCI.
The characteristics of arterial spin labeling cerebral blood flow in patients with subjective cognitive decline: The Chinese imaging, biomarkers, and lifestyle study
Authors: Li Wenyi , Jiang Jiwei , Zou Xinying , Zhang Yuan , Sun Mengfan , Jia Ziyan , Li Wei , Xu Jun 
Published: August 2022

ObjectiveWe aimed to characterize the potential risk factors and cerebral perfusion of patients with subjective cognitive decline (SCD).MethodsThis prospective study enrolled consecutive patients from the Chinese Imaging, Biomarkers, and Lifestyle (CIBL) Cohort of Alzheimer’s disease between February 2021 and March 2022. Patients who met the SCD diagnostic criteria were categorized into the SCD group, while those without cognitive complaints or any concerns were assigned to the healthy control (HC) group. The demographic and clinical characteristics and cerebral blood flow (CBF) from pseudo-continuous arterial spin labeling (pCASL) in standard cognitive regions were compared between these two groups. A multivariate analysis was performed to identify independent factors associated with SCD.ResultsThe frequency of family history of dementia in the SCD group was higher compared with the HC group (p = 0.016). The CBF of left hippocampus (p = 0.023), left parahippocampal gyrus (p = 0.004), left precuneus (p = 0.029), left middle temporal gyrus (p = 0.022), right parahippocampal gyrus (p = 0.018), and right precuneus (p = 0.024) in the SCD group were significantly increased than those in the HC group. The multivariate logistic regression analyses demonstrated that the family history of dementia [OR = 4.284 (1.096–16.747), p = 0.036] and the CBF of left parahippocampal gyrus [OR = 1.361 (1.006–1.840), p = 0.045] were independently associated with SCD.ConclusionThis study demonstrated that the family history of dementia and the higher CBF within the left parahippocampal gyrus were independent risk factors associated with patients with SCD, which could help in the early identification of the SCD and in intervening during this optimal period.
Long-term follow-up of early stage HER2-positive breast cancer patients treated with trastuzumab: A population-based real world multicenter cohort study
Authors: Ellegård Sander , Engvall Kristina , Asowed Mustafa , Hallbeck Anna-Lotta , Elander Nils , Stål Olle 
Published: August 2022

IntroductionSince its introduction in standard of care, trastuzumab has revolutionized the treatment of patients with early and late stages of HER2-positive breast cancer. While the initial clinical trials were convincing and lead to major changes in practice, more knowledge on the long-term outcome and tolerability is needed. The present study was designed to assess the survival, prognostic factors and relapse patterns after the implementation of trastuzumab in a real-world cohort.MethodsAll cases of HER2-positive breast cancer diagnosed between 2006 and 2014 in the Southeast Healthcare Region of Sweden were retrospectively identified. Medical records were thoroughly reviewed with regard to clinicopathological parameters, treatments, relapse pattern and adverse events.Results643 patients were identified and 599 were eligible for analysis. Breast cancer specific survival, distant recurrence free survival and local recurrence free survival were 93.4%, 89.7% and 98.0% for trastuzumab treated patients and 87.4%, 81.6% and 87.4% in patients not treated with trastuzumab, respectively. ER status, nodal status and trastuzumab treatment were all independent prognostic factors in multivariable analysis. No new safety concerns were discovered.ConclusionThe real-world outcome of trastuzumab-treated patients with early HER2-positive breast cancer is similar to what has been previously reported in long-term follow up of prospective clinical trials. ER status, nodal status and trastuzumab treatment are independent prognostic factors for breast cancer specific mortality rate, distant recurrence rate and locoregional recurrence rate in HER2-positive patients in the trastuzumab era.
The clinical evaluation of atlas-based auto-segmentation for automatic contouring during cervical cancer radiotherapy
Authors: Li Yi , Wu Wenjing , Sun Yuchen , Yu Dequan , Zhang Yuemei , Wang Long , Wang Yao , Zhang Xiaozhi , Lu Yongkai 
Published: August 2022

PurposeOur purpose was to investigate the influence of atlas library size and CT cross-slice number on the accuracy and efficiency of the atlas-based auto-segmentation (ABAS) method for the automatic contouring of clinical treatment volume (CTV) and organs at risk (OARs) during cervical cancer radiotherapy.MethodsOf 140 cervical cancer patients, contours from 20, 40, 60, 80, 100, and 120 patients were selected incrementally to create six atlas library groups in ABAS. Another 20 tested patients were automatically contoured with the ABAS method and manually contoured by the same professional oncologist. Contours included CTV, bladder, rectum, femoral head-L, femoral head-R, and spinal cord. The CT cross-slice numbers of the 20 tested patients included 61, 65, 72, 75, 81, and 84. The index of dice similarity coefficients (DSCs) and Hausdorff distance (HD) were used to assess the consistency between ABAS automatic contouring and manual contouring. The randomized block analysis of variance and paired t-test were used for statistical analysis.ResultsThe mean DSC values of “CTV, bladder, femoral head, and spinal cord” were all larger than 0.8. The femoral head and spinal cord showed a high degree of agreement between ABAS automatic contouring and manual contouring, with a mean DC &gt;0.80 and HD &lt;1 cm in all atlas library groups. A post-hoc least significant difference comparison indicated that no significant difference had been found between different atlas library sizes with DSC and HD values. For ABAS efficiency, the atlas library size had no effect on the time of ABAS automatic contouring. The time of automatic contouring increased slightly with the increase in CT cross-slice numbers, which were 99.9, 106.8, 114.0, 120.6, 127.9, and 134.8 s with CT cross-slices of 61, 65, 72, 75, 81, and 84, respectively.ConclusionA total of 20 atlas library sizes and a minimum CT cross-slice number including CTV and OARs are enough for ensuring the accuracy and efficiency of ABAS automatic contouring during cervical cancer radiotherapy.
Neoadjuvant chemoradiotherapy with camrelizumab in patients with locally advanced esophageal squamous cell carcinoma
Authors: Chen Fei , Qiu Lingdong , Mu Yushu , Sun Shibin , Yuan Yulong , Shang Pan , Ji Bo , Wang Qifei 
Published: August 2022

BackgroundNeoadjuvant anti-programmed death receptor-1 (PD-1) blockade has been reported to improve the prognosis of locally advanced esophageal squamous cell carcinoma (ESCC). This study was aimed to evaluate the efficacy and safety of neoadjuvant camrelizumab plus chemoradiotherapy in locally advanced ESCC.MethodsWe retrospectively enrolled ESCC patients who received camrelizumab plus chemoradiotherapy as neoadjuvant therapy before surgery from May 2019 to September 2021.ResultsA total of 38 eligible patients were enrolled. The neoadjuvant treatment was well tolerated with no serious treatment-related adverse events. 36 (94.7%) patients achieved a R0 resection without hospital mortality or any other serious intraoperative complications. The objective response rate (ORR) was 63.2% and the disease control rate (DCR) was 100.0%. The major pathological response (MPR) was 50.0% and the complete pathological response (pCR) was 39.5%. With a median follow-up of 18.5 months, 6 (15.8%) patients had died. The overall survival (OS) and disease-free survival (DFS) at 12 months were 87.6% and 78.7%, respectively. Subgroup analysis demonstrated that patients who got MPR or pCR achieved improved survival, while PD-L1 expression did not reach statistically difference in predicting survival.ConclusionsNeoadjuvant camrelizumab plus chemoradiotherapy is safe and efficacious in treating patients with locally advanced ESCC.
Introducción al Dossier: "Cuando sea grande": algunas derivaciones de la obra de Martha Bechis
Authors: Cutrera María Laura , Morrone Ariel J. 
Published: August 2022

La obra de Martha Bechis fue prolífica y abrevó en marcos teóricos diversos -teoría de las catástrofes, del caos o de los cambios discontinuos y del juego y del drama, la cibernética, el análisis del discurso y de las formaciones del estado- y reflexionó permanentemente sobre la etnohistoria de la Panaraucanía. Su centralidad en el campo disciplinar trascendió sus contribuciones teóricas, históricas o analíticas pues tenía el don de escribir con sencillez, haciendo que nociones o conceptos complejos resultaran fáciles de comprender, por lo que sus trabajos suelen ser disparadores inagotables de ideas. Además cabe destacar otro aspecto que consideramos fundamental en el crecimiento del campo disciplinar del que fue pionera: su enorme generosidad, ya que dedicó buena parte de su tiempo, paciencia y amabilidad a formar discípulos que hoy integran ese campo, de ahí la motivación para la preparación y publicación de este dossier.
Elements of Life of the Pandvar People in the Novel Korkai
Authors: P Johnson 
Published: July 2022

Joe D. Cruz titled the novel Korkai, which travels through time more than a century. Korkai is an ancient port city ruled by the Early Pandyan Kingdom. It tells the long history of the Pandavas of Tuticorin. It is also a great resource to learn about the life of the marine fisher folk. This book, which accurately and artistically explains the changes brought about in the Bharatava society by the domination of foreigners, the arrival of Christianity, the liberation struggles, the changes that took place in independent India, and the arrival of modernity, is also a document that includes all the elements of a race's identity, culture, life, and history. The events of the novel begin in 1914 and conclude in the year 2000. During this period, over two hundred Pandavar social men of Korkai came and went over four generations. The story is shaped by the subtle depiction of various events and different faces of people, as well as the astonishing spheres of change. This novel tells the stories of three generations of thirty thousand families through the language of the coast as a beautiful fiction about the changes in the lives of the people who own the woven land after European arrival. It starts with the death of the Pandava community leader and unfolds before us countless scenes before the flood of eighty-six years and ends with the death of the character Philip. The novel not only talks about the people but also the social, economic, and cultural changes that took place during these times. After the Portuguese and the British left the country and the native government came, the ‘Korkai’ novel is an excellent source to explore how the Pandava community that lived in Korkai established itself and cane beyond the flood of time. The purpose of this article is to identify the richness of the woven land, the pride, the valor, characteristics, beliefs, elements of worship, and the activities that hinder the development and progress of the people of the maritime people.
HUBUNGAN PENGETAHUAN DAN SIKAP DENGAN TINDAKAN 3M PLUS PADA IBU RUMAH TANGGA DI KELURAHAN TANJUNG RANCING TAHUN 2022
Authors: Alya Danisa Devara , Ridwan  , Anwar Khairil 
Published: August 2022

Upaya memberantas jentik nyamuk di wilayah kerja Puskesmas Kutaraya pada tahun 2020 memiliki capaian sebesar 66% dan di wilayah kerja Puskesmas Kutaraya, terdapat satu Kelurahan terendah memberantas jentik nyamuk yaitu Kelurahan Tanjung Rancing baru mencapai 58%. Indikator tersebut tidak berhasil karena target harus dicapai untuk indikator memberantas jentik nyamuk adalah 95% Sesuai dengan peraturan menteri kesehatan nomor 50 tahun 2017. Tujuan penelitian ini adalah untuk mengetahui hubungan pengetahuan dan sikap dengan tindakan 3m plus pada ibu rumah tangga di Kelurahan Tanjung Rancing. Penelitian ini merupakan penelitian analitik dengan pendekatan cross sectional study. Sampel pada penelitian ini adalah 100 orang ibu rumah tangga.Teknik pengambilan sampel adalah Proportionate Stratified Random Sampling. Analisis data yaitu analisa univariat dan analisa bivariat yang menggunakan Chi Square. Dari 100 responden ibu rumah tangga terdapat 59% memiliki pengetahuan baik, 51% memiliki sikap negatif, dan 53% memiliki tindakan kurang baik. Hasil uji statistik Chi-Square diperoleh nilai p<0,05 (p=0,001) artinya ada hubungan antara pengetahuan dengan tindakan 3m plus serta nilai p<0,05 (p=0,017) artinya ada hubungan antara sikap dengan tindakan 3m plus maka dapat disimpulkan bahwa ada hubungan yang signifikan antara pengetahuan dan sikap dengan tindakan 3m plus pada ibu rumah tangga di Kelurahan Tanjung Rancing.
La seguridad de los pacientes en cuidados intensivos
Authors: Pico-Macías Anggie Evelyn , Mesías-Mercado Emma Marisela , Mendoza-Pico Valeria Valentina , Maigual Cabrera Diana Yurani 
Published: August 2022

El objetivo general de la presente investigación fue analizar la seguridad de los pacientes en cuidados intensivos. Se desarrolló desde el enfoque cuantitativo, a través de la búsqueda, recolección y análisis crítico documental, referencial bibliográfico y trabajos científicos arbitrados, desde un diseño bibliográfico de tipo documental, los investigadores organizaron y planificaron el proceso de investigación donde la población de estudio lo conformó principalmente documentos escritos, tesis, revistas arbitradas para indagar los escritos con el propósito de escrutarlos y construir conclusiones generando nuevos conocimientos. Para la técnica de interpretación de la indagación, se consideró el análisis de contenido de la información recopilada, lo que permitió la formulación de resultados. Se concluye, que es necesario establecer mediante la gestión de salud, estrategias y políticas para fortalecer la seguridad de los enfermos que acuden a los centro de salud y en especial a los ingresos a UCI (Unidad de cuidados intensivos), pacientes graves.
Medidas de bioseguridad en el contagio de tuberculosis pulmonar en el personal de salud
Authors: Zegarra-Sánchez Cynthia Eugenia 
Published: August 2022

El objetivo se basó en determinar la relación entre las Medidas de Bioseguridad del personal y el nivel de contagio de la TBC en el Hospital Hipólito Nacional Unanue, 2021. El diseño fue de tipo observacional, descriptivo, transversal y retrospectivo. Existe una relación significativa entre las Medidas de Bioseguridad y el nivel de contagio de la TBC en el Hospital Hipólito Nacional Unanue, 2021. De los 264, profesionales consultados la gran mayoría conoce y aplica correctamente las medidas de bioseguridad en las distintas áreas evaluadas, contribuyendo de esta manera a reducir significativamente la curva de contagios en pacientes TBC en el mencionado centro de salud, en comparación con años anteriores, estadísticamente para el momento de la investigación se atendieron 60 % de casos Nuevos de TBC, 20% Continuadores y 20 % resistente.
Transmission structural-color characteristics of Al-ZrO2-SiO2 plasmonic linear gratings
Authors: Ham Sangwon , Ju Byeong-Kwon , Kim Hwi 
Published: August 2022

Abstract
This paper investigates the color characteristics of Al-ZrO2-SiO2 plasmonic linear gratings, particularly focusing on the trade-off between the purity of the surface plasmon resonance induced color and the transmission efficiency. In our proposed plasmonic color filter, the factor that determines the resonance wavelength is the grating period, and the main factor controlling the relationship between color purity and transmittance is the grating fill factor, i.e. duty ratio. This means that the bandwidth of the transmittance spectrum can be tuned using the fill factor. Its physical reasoning is described. A full-color pallet is fabricated in the form of an Al-ZrO2-SiO2 linear grating with a fixed thickness and adjusted pairings of the grating period and fill factor.