bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics and therapeutic strategies of radiation-induced glioma : case series and comprehensive review of the literature
Authors: Onishi Shumpei , Yamasaki Fumiyuki , Amatya Vishwa Jeet , Takayasu Takeshi , Yonezawa Ushio , Taguchi Akira , Ohba Shinji , Takeshima Yukio , Horie Nobutaka , Sugiyama Kazuhiko 
Published: June 2022

Abstract
Introduction: Secondary glioma after cranial irradiation, so-called radiation-induced glioma (RIG), is one of the serious late effects after cranial radiation therapy. However, clinical characteristics and ideal treatment strategies of these tumors are unclear. In this report, we analyzed our case series and conducted a comprehensive review to reveal the characteristics of RIG.Methods: We performed literature review and investigated individual cases. In our institutes, we found pathologically diagnosed 6 cases of RIG. Totally, 360 cases were analyzed. The latency periods from irradiation to development of RIG and median overall survival of RIGs were analyzed with Kaplan-Meier analysis. Spearman’s correlation test was used to determine the relationship between age at irradiation and the latency years.Results: The mean age at the development of RIG was 27.42±17.87 years and the mean latency periods was 11.35±8.58 years. Multiple gliomas were observed in 28.4%. WHO grade 3 and 4 RIGs were account for 93.3%. The latency periods showed significant shorter in higher WHO grade group (p=0.0366) and concomitant systemic chemotherapy group (p<0.0001). Age at irradiation was negatively associated with the latency periods (r=-0.2287, p=0.0219). RIG treated with radiotherapy showed longer survival compared to RIG treated without radiotherapy (p=0.0011).Conclusions: Development in younger age, multiplicity, and high incidence of grade 3 and 4 are the clinical characteristics of RIG. Cranial irradiation at older ages, and concomitant chemotherapy were associated with a shorter latency period for the development of RIG. Radiation therapy is the feasible treatment option despite radiation-induced gliomas.
IoT-enabled Pest Identification and Classification with New Meta-Heuristic-based Deep Learning Framework
Authors: kathole atul b 
Published: June 2022

Abstract
The insect pests and crop diseases are the most critical factors that affect agricultural production, which reduces the sustainable development of agriculture. While detecting the pest, it is inconsistent to place the surveillance cameras near the target pests and the captured images from the Internet of Things (IoT) monitoring equipment at a constant location that is mostly insufficient for pest detection. IoT is a well-known advanced technology and an analytics system incorporated in diverse industries based on its unique abilities and flexibilities over a particular environment like agriculture. There is a demand for the IoT in agricultural areas to reduce the chemical crop protection agents and fertilizers to manage the efficient crop state and crop production. Hence, the data collection is through the IoT devices in this research model. This research aims to develop a pest identification and classification model to detect and identify the pests in the images. Initially, the IoT platform is created, and IoT devices conduct the data collection. Then, object detection is performed using Yolov3 to detect the pests in the images from the gathered images. The detected images are subjected to the Convolutional Neural Network (CNN) for gathering the deep features, which are then forwarded to the enhanced classifier, termed Convolution Neural Long Short-Term Memory (CNLSTM) for getting the classified outcomes as pest details, in which the optimization of parameters is done by Adaptive Honey Badger Algorithm (AHBA). These results demonstrated that the proposed method shows enhanced performance by rapidly collecting the information in agriculture and ensures the technical indication for population estimation and pest monitoring.
Incomplete excision of the intrapancreatic part of choledochal cyst lead to malignant transformation- Technical challenges and management
Authors: Mulpuri Venu Bhargava , Bhuria Dinesh Kumar , Rana Surinder Singh , Gupta Rajesh 
Published: June 2022

Abstract
Complete excision of the choledochal cyst is the procedure of choice for a choledochal cyst. Excision of the intrapancreatic portion of the choledochal cyst poses a technical challenge especially when the distance between the union of the pancreatic duct and common bile duct cyst is < 5mm and when the entire intrapancreatic bile duct is dilated. We present a case of malignant transformation of the intrapancreatic portion of the choledochal cyst following delay in the identification of choledochal cyst and incomplete excision.
Conformal Vector Fields on F-cosymplectic Manifolds
Authors: Sardar Arpan , De Uday Chand 
Published: June 2022

Abstract
In this paper, at first we characterize f-cosymplectic manifolds admitting conformal vector fields. Next, we establish that if a 3-dimensional f-cosymplectic manifold admits a homothetic vector field V, then either the manifold is of constant sectional curvature -\tilde{f} or, V is an infinitesimal contact transformation. Furthermore, we also investigate η-Ricci-Yamabe soliton with conformal vector fields on f-cosymplectic manifolds. At last, two examples are constructed to validate our outcomes.
The association between sugar at breakfast and energy intake in people with or at high risk of type 2 diabetes: a within-person analysis of STAMP-2 data
Authors: Carroll Harriet A. , Toumpakari Zoi , Andrews Robert C. , Falconer Catherine , James Lewis J. , Betts James A. , England Clare , Cooper Ashley R. , Johnson Laura 
Published: June 2022

Abstract
Background: The role of nutrient timing in energy intake amongst people with dysglycaemia is understudied but could be a simple method to help regulate appetite. This study analysed within-person associations of sugar intake at breakfast and subsequent energy intake. Methods: We used 4-day diet diary data from 147 participants (47 % men) encompassing 547 days of diet recording in the Sedentary Time and Metabolic Health in People with Type 2 diabetes project (STAMP-2). Linear two-level models were used to investigate within- (day-level) and between-person (participant-level) variation in total and post-breakfast energy intake according to skipping breakfast, low- (> 0-14.2 g) or high- (> 14.2 g) sugar intake at breakfast, adjusting for potential confounding or mediation. Results: Post-breakfast energy intakes were observed to be lower after eating low- and high-sugar breakfasts (compared to skipping), but higher total energy intake was associated with eating a high-sugar breakfast. Compared to breakfast skipping, both low- and high-sugar breakfasts were strongly associated with lower post-breakfast energy intake (-178, 95 % confidence interval [CI] -261, -94 kcal/d; ‑151, 95 % CI -235, -67 kcal/d, respectively). However, compared to skipping breakfast, low-sugar breakfasts were weakly associated with higher total daily energy intake (64, 95 % CI -18, 146 kcal/d), whereas high-sugar breakfasts had a strong association (135, 95 % CI 52, 217 kcal/d). Post-breakfast energy intakes were similar between low- and high-sugar breakfast days (27, 95 % CI -53, 106 kcal/d), whilst total daily energy intake tended to be higher with high- (compared to low-) sugar breakfasts (70, -8, 149 kcal/d). We also observed evidence of energy compensation whereby 86 % of the extra energy consumed in a low-sugar breakfast was compensated for by reductions in post-breakfast energy intakes, compared to only 53 % after a high-sugar breakfast. Conclusion: Overall, high-, but not low-, sugar breakfasts were associated with higher total daily energy intake when compared to breakfast skipping, despite a similar reduction in post-breakfast energy intake. We found evidence of poorer post-breakfast energy intake compensation with high-sugar breakfasts than low-sugar breakfasts. These findings suggest portion size may be important to consider in future breakfast research, with sugar being a proxy of portion size.
PERAN GURU PAI DALAM PEMBELAJARAN BERBASIS ‎‎TEKNOLOGI INFORMASI UNTUK MENCEGAH PAHAM ‎‎RADIKALISME SISWA DI SDIT AL-HUSNA GONDANG ‎‎TULUNGAGUNG
Authors: Thohiri M. Kholid , Ernawati Ernawati 
Published: June 2022

Abstrak : Guru Pendidikan Islam mempunyai peran vital untuk memberikan pemahaman tentang toleransi dan akidah yang benar dengan tidak mengesampingkan nilai-nilai kebhinekaan dan kebangsaan, sebagai bekal untuk dapat mencegah konflik antar umat Islam maupun umat beragama lain, serta menghindari ajaran radikal untuk mencegah aksi-aksi kekerasan yang mengatasnamakan agama. Dalam penelitian ini mengungkap peran dan upaya strategis guru Pendidikan Agama Islam dalam menangkal radikalisme melalui pembelajaran berbasis teknologi informasi di SDIT Al-Husna Gondang Tulungagung. Metode penelitian yang digunakan adalah jenis penelitian kualitatif dengan teknik pengumpulan data observasi, wawancara dan dokumentasi. Sedangkan analisis data dengan langkah reduksi, display data dan konklusi. Teknik keabsahan data menggunakan trianggulasi dan diskusi sejawat. Hasil penelitiannya adalah peran guru PAI sebagai perencana, mediator, fasilitator, dan filter dalam proses pembelajaran PAI berbasis teknologi Informasi yang berwawasan nilai-nilai moderasi Islam.
Abstrack: Islamic education teachers have a vital role to provide an understanding of tolerance and the correct creed without neglecting the values ​​of diversity and nationality, as a provision to prevent conflicts between Muslims and other religious communities, and avoid radical teachings to prevent violent acts. In this study reveals the role and strategic efforts of Islamic Religious Education teachers in counteracting radicalism through information technology-based learning at SDIT Al-Husna Gondang Tulungagung. The research method used is a type of qualitative research with observation data collection techniques, interviews and documentation. Meanwhile, data analysis using reduction steps, data display and conclusion drawing. The data validity technique used triangulation and peer discussion. The result of the research is the role of Islamic Education teachers as planners, mediators, facilitators, and filters in the learning process of Islamic Education based on Information technology with the insight into Islamic moderation values.
Modes of access to water for domestic use in rural Chile: a typological proposal
Authors: Chloé Nicolas-Artero , Gustavo Blanco , Carlos Bopp , Noelia Carrasco 
Published: June 2022

Abstract
A typology is proposed regarding the modes of access to water for the rural population in Chile as well as four explanatory dimensions of its heterogeneity. The typology emerges from a systematic review of the literature and an analysis of quantitative data based on rural water organizations' databases. The modes of access are defined by the following five criteria: their socio-technical system, their type of management, their level of spatial action, the source of their financing, and the type of technical assistance they received. The findings dispute the systemic vision of access to water in rural areas and invite us to consider the structural heterogeneity in regulations and public policies to guarantee the human right to water.
Determination of Bioactive Protein Product Produced During Fermentation Using an Optical Biosensor
Authors: Gill Andrew , Harrison Joanna , Holwill Ian , Lowe Peter A , Hoare Mike 
Published: June 2022

Abstract:
The fermentation of Escherichia coli to produce recombinant antibody fragments, Dl.3 Fv, specific for hen egg lysozyme, has been studied. The expression of antibody fragments has been monitored using an optical biosensor system to detect bioactive Fv in broth and cell homogenate supcrnatants during the course of fermentation. The system has permitted rapid detection, within seconds of sample application to the sensor, of bioactive product. Increase in pcriplasmic product was first detected 4 hours after inoculation of the vessel.
Complete Amino Acid Sequences of Two γ-Thionins From Maize (Zea Mays L.) Seeds
Authors: de Souza Castro Mariana , Fontes Wagner , Morhy Lauro , Bloch Jr. Carlos 
Published: June 2022

Abstract:
Two γ-thionins were purified from maize (Zea mays L.) seeds by saline extraction, ammonium sulfate precipitation, pseudo-affinity and RP-HPLC chromatographies. Their complete amino acid sequences were determined by automated Edman degradations of the intact and S-alkylated proteins and peptides obtained from proteolytic digests and confirmed by ES/MS analysis. These sequences show remarkable homology with sorghum α-amylase isoinhibtors.
Increased Circulating Pentraxin 3 Levels in Patients with Rheumatoid Arthritis: A
Meta-analysis
Authors: Guan Shi-Yang , Chen Yuting , Shao Ming , Yang Hui , Xu Wei , Shuai Zongwen , Zhao Hui , Zhao Dahai , Pan Faming 
Published: June 2022

Background:
Pentraxin 3 (PTX3) as a soluble pattern recognition molecule not only acts as a promising indicator reflecting the disease activity of rheumatoid arthritis (RA) patients, but exerts essential pathogenic roles in the progression of RA and serves as a potential therapeutic target for RA patients. Our study intends to systematically evaluate the circulating PTX3 levels and their potential influencing factors in RA patients.

Methods:
Articles regarding the circulating PTX3 levels of RA patients were identified in Pubmed, Embase, China National Knowledge Infrastructure (CNKI), and Cochrane databases. Standardized mean difference (SMD) and corresponding 95% confidence intervals (95% CI) were calculated and further illustrated by the forest plot. Egger’s regression test and sensitivity analysis were conducted to assess the publication bias and stability of the results, respectively.

Results:
Twenty articles with 21 individual studies were recruited in our meta-analysis. The overall results revealed that compared with healthy controls, RA patients had significantly higher circulating PTX3 levels (pooled SMD = 0.97, 95% CI: 0.48 to 1.45). Subgroup analyses further demonstrated that compared with healthy controls, RA patients of age ≤ 50 years, 2.6 < disease activity score in 28 joints (DAS28) ≤ 3.2, 3.2 < DAS28 ≤ 5.1, DAS28 > 5.1, C-reactive protein (CRP) levels > 10 mg/L, erythrocyte sedimentation rate (ESR) > 20 mm/h, and disease duration > 5 years had significantly higher circulating PTX3 levels, respectively; whereas RA patients of age > 50 years, DAS28 ≤ 2.6, CRP levels ≤ 10 mg/L, ESR ≤ 20 mm/h and disease duration ≤ 5 years had no significantly altered circulating PTX3 levels, respectively. Additionally, no matter the patients of Caucasian ethnicity or not, circulating PTX3 levels were significantly increased in RA patients.

Conclusion:
Compared with healthy controls, circulating PTX3 levels are significantly increased in RA patients, which are influenced by the age, disease activity, CRP levels, ESR, and disease duration of the patients.
Thiourea-Catalyzed Amidation of Esters: A New Method for the Preparation
of Amides
Authors: Davis Todd A. , Garza Audrey B. , Miller Rebecca G. , Gardner Steven B. , Fuhrer Timothy J. , Campbell Alicia B. 
Published: June 2022

Abstract:
Although amides are one of the most abundant bonds in biology and medicinal chemistry,
methods to prepare them are still limited. To expand on current methods for the formation of amides
bonds, organocatalysts (thiourea-based) were developed to mediate the conversion of esters to amides.
The reactions proceed in good to moderate yields and tolerate a variety of functional groups. 1
H NMR
titration and computational studies show a strong hydrogen-bonding interaction between the thiourea
catalyst and the ester moiety. This hydrogen-bonding interaction is proposed to be the driving force for
the amidation of esters.
Synthetic PARP-1 Inhibitors Reported During the Last Decade
Authors: Guleria Maneesh , Kumar Pradeep , Thareja Suresh 
Published: June 2022

Background:
Cancer is the world's second largest cause of death and is responsible for an estimated 9.6 million mortalities in 2018. Poly-ADP-ribose polymerases (PARPs) are enzymes and family of proteins, involved in many cellular processes, including DNA repair, gene regulation, chromatin remodeling, and apoptosis. The first characterized and best known member of the PARP family is poly(ADP-ribose) polymerase 1 (PARP-1). PARP-1 is a major protein for DNA single-strand breaks in the BER pathway (base excision repair) (SSBs).

Objective:
The objective of this article was to compile synthetic PARP-1 inhibitors reported in the last decade

Methods:
In the present manuscript, bibliographic investigation was carried out by scrutinizing peerreviewed
articles from online/offline databases. The inclusion criteria consisted of the most relevant studies
indicating the relationship between PARP-1 and cancer in textbooks/edited books and peer-reviewed
papers from scientific databases, like SCOPUS, PUBMED, NISCAIR, and Google Scholar since 2010 to
2020. Only the studies published in English language were searched/considered. The exclusion criteria
consisted of the studies on other PARP isoforms than PARP-1. The studies thus obtained were classified
according to the heterocyclic moieties, year of publication, etc. The data compiled in this article is a systematic
review of the reported studies.

Results:
The literature reports indicated that a number of PARP-1 inhibitors reported have IC50 value in nanomolar concentration.

Conclusion:
PARP-1 is an essential target for anti-cancer drug discovery. Further, research for more effective and safe PARP-1 inhibitors is carried out and we may discover some novel PARP-1 inhibitors in the near future.
Evaluation of CT Scan Diagnostic Value in the Novel Coronavirus Disease
and Presenting a Corona CT Severity Index
Authors: Taheri Abdolmajid , Asadi-Samani Majid , Dezaki Ebrahim Saedi , Kheiri Soleiman , Taheri Elham 
Published: June 2022

Background:
Several diagnostic methods have been proposed and evaluated for the COVID-19 disease. However, the published studies have reported different diagnostic values for these methods.

Aims:
The present study aimed to evaluate the diagnostic performance and accuracy of CT in the novel corona virus disease (COVID-19) and to develop and present a Corona CT severity index.

Methods:
The CT diagnostic performance was measured based on sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy, and RT-PCR was regarded as a standard. Patients’ CT reports were evaluated by a radiologist, and scoring and calculating of the CT severity index were performed.

Results:
Of 208 patients, 82 showed positive and 126 showed negative RT-PCR results with a positive frequency of 39.4% (95% CI, 32.7-46.4). The chest CT scan related to 136 patients indicated COVID-19, whereas their initial RT-PCR assays of 56 patients were negative. Considering RT-PCR results as reference standard, the sensitivity, specificity, and accuracy of chest CT to indicate COVID-19 infection was 100%, 55.6% (95% CI 46.4-64.4%), and 72.8% (95% CI 66.2-78.8%), respectively. The severity of pulmonary involvement was assigned with different grades. For 60.7% of patients with severity grades of 2 to 6, who showed the involvement of at least one lung lobe in CT, PCR retrieved negative results.

Conclusion:
CT scan represents an appropriate sensitivity as well as a consistently higher specificity to diagnose COVID-19 pneumonia than PCR. It can be regarded as a primary tool to detect the current COVID-19 in epidemic regions.
A Rare Case of Extrauterine Endometrial Stromal Sarcoma Arising from
Deep Pelvic Endometriosis: Role of Multidisciplinary Team Meeting
Authors: Long Xueying , Pei Yigang , Masokano Ismail Bilal , Zhu Xin , Lin Wei , He Siting , Liu Hui 
Published: June 2022

Introduction:
Extrauterine endometrial stromal sarcoma (EESS) arising from Deep pelvic
endometriosis (DPE) has a poor life quality and is difficult to diagnose pre-operatively. However, the
patient’s quality of life can be improved when it is diagnosed precisely and managed successfully.

Case report:
A 35‑year‑old woman presented to our hospital with a 3-month history of hematochezia
and anal pain. Initially, she was misdiagnosed as a rectal stromal tumor and then precisely diagnosed
as having EESS from DPE following several multidisciplinary team (MDT) meetings. The lesion was
shrunk by gonadotrophin-releasing hormone agonist (GnRH-α) treatment and then resected with minimal
trauma.

Conclusions:
MDT is crucial in the treatment of the patient. It can promote individualized treatment
and improve patient’s quality of life.
Elemicin-rich Cymbopogon khasianus (Hack) Stapf (ex Bor) Essential Oil:
Pharmacological Effects, Toxicological Investigation, and Compositional
Analysis
Authors: Gogoi Roktim , Begum Twahira , Sarma Neelav , Pandey Sudin Kumar , Bhandari Sangeeta , Saikia Samarjit , Tamang Raghu , Saikia Raktim Jyoti , Lal Mohan 
Published: June 2022

Background:
Cymbopogon khasianus is a widely used industrial and pharmacologically important aromatic grass species.

Objective:
The present investigation was designed to study and compare the elemicin rich Cymbopogon khasianus essential oil (EREO) and its pharmacological effects, genotoxicity with pure compound elemicin

Materials and Methods:
Chemical composition, identification was performed using GC/MS and NMR techniques. 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH), reducing power assay for antioxidant; albumin denaturation, protease inhibitor for anti-inflammatory; acetylcholinesterase (AChE) for anti-cholinesterase; amylase inhibitory for anti-diabetic; tyrosine inhibitory for skin whitening; disc diffusion and minimum inhibitory concentration assay for antimicrobial, and Allium cepa assay for genotoxicity were used.

Results:
GC/MS analysis identified 38 compounds; among them elemicin 72.34%, D-limonene 3.81%; methyl eugenol 3.34% were the major compounds. A significant amount of antioxidant activity IC50 31.38 µg/mL; anti-inflammatory activity (protein denaturation assay) IC50 16.77 µg/mL; protease inihibitor assay IC50 51.08 µg/mL; anticholinesterase IC50 12.095 µg/mL; antidiabetic activity IC50 17.36 µg/mL; and anti-tyrosinase activity IC50 17.69 µg/mL were reported. Antimicrobial activity analysis against 13 microbial strains revealed negative effect. Genotoxicity study using Allium cepa assay revealed negative toxicity of EREO with aberration percentage of 04.30% and pure elemicin 05.30% which was very low in comparison to ethyl-methanesulfonate (EMS) 13.90%.

Conclusion:
To the best of our knowledge this is the first scientific evaluation of novel elemicin rich EREO pharmacological properties and to compare with pure compound elemicin. Together, it can be stated that EREO possesses antioxidant, anti-inflammatory, anti-cholinesterase activities way better than pure compound elemicin as well as standard drugs used.