bluuebunny/crossref_metadata_2025_split huggingface dataset:
Criando niños saludables: Familias activas
Authors: Stolarz Jamie C. , Shelnutt Karla P. 
Published: May 2022

¿Recuerda aquellos juegos como la rayuela, congelados y tirar la pelota para correr a diferentes bases cuando estaba en el recreo en la escuela primaria? Se sentía muy bien estar afuera, su sangre fluyendo y sus músculos trabajando. La actividad física no es una cosa del pasado. Puede ser una actividad divertida en su vida diaria. Entonces, ¿Qué espera? ¡Es hora de tomar a su familia y empezar a moverse! Esta publicación resalta los beneficios de salud y recomendaciones de la actividad física. Además, incluye consejos para estar activos y sugerencias de actividades divertidas que toda la familia junta puede realizar.
This 4-page fact sheet is the Spanish-language version of FCS8922/FY1192: Physical Activity for Families. It highlights the health benefits of physical activity, includes tips for being active, and suggests fun activities that the whole family can do together. Written by Jamie C. Stolarz and Karla P. Shelnutt, and published by the UF Department of Family, Youth and Community Sciences, October 2011.
PENERAPAN STRATEGI PEMBELAJARAN QUANTUM TEACHING SEBAGAI UPAYA MENINGKATKAN KEAKTIFAN BELAJAR MATEMATIKA DI KELAS VII.1 SMP NEGERI 2 AIRPURA
Authors: Elmiyati Elmiyati 
Published: May 2022

Penelitian ini bertujuan untuk meningkatkan Keaktifan belajar siswa dalam mata pelajaran Matematika melalui penerapan strategi pembelajaran quantum teachingSMP Negeri 2 Airpura Kabupaten Pesisir Selatan.Penelitian ini tergolong pada PTK yang berlangsung dua siklus setiap siklus terdiri dari tiga kali pertemuan.Disamping itu setiap satu kali pertemuan terdiri dari empat tahapan mulai dari perencanaan, pelaksanaan, observasi dan refleksi.Tindakan dilakukan di kelas VII.1 dimana siswa terdiri dari 31 orang. Peneliti dalam penelitian dibantu oleh seorang observer yaitu yang berperan sebagai pengamat.Data penelitian dianalisis dengan formula persentase yang menggambarkan data sebagai mana adanya. Hasil penelitian meliputi:Pembelajaran Matematika pada siswa kelas VII.1 SMP Negeri 2 Airpura dengan menggunakan strategi pembelajaran Quantum TeachingBerdasarkan hasil penelitian tindakan kelas yang telah dilakukan, maka diambil kesimpulan bahwa tingkat keaktifan siswa sebelum diadakan penelitian tindakan kelas adalah hanya 9 siswa Kata Kunci: Strategi Pembelajaran Quantum Teaching, Keaktifan Belajar Matematika
ANALISIS PENGARUH PERPUTARAN KREDIT TERHADAP RENTABILITAS EKONOMI (STUDI KASUS PADA KOPERASI PEGAWAI REPOBLIK INDONESIA (KPRI) OBOR KOTA BIMA)
Authors: Hartoyo Hartoyo , Wahyuni Wahyuni 
Published: May 2022

Tujuan penelitian ini adalah untuk mengetahui pengaruh perkembangan tingkat perputaran kredit dan tingkat rentabilitas ekonomi pada Koperasi Pegawai Repoblik Indonesia (KPRI) Obor kota Bima. Jenis penelitian yang digunakan dalam penelitian ini adalah studi kasus. Adapun yang menjadi subyek dalam penelitian ini adalah pengurus, pengawas, anggota dan karyawan pada Koperasi Pegawai Repoblik Indonesia (KPRI) Obor Bima untuk di wawancarai mengenai data yang dibutuhkan. Analisis data penelitian ini menggunakan Analisis dinamis yaitu penganalisaan antara pos-pos yang terdapat dalam laporan keuangan pada beberapa periode, atau yang lebih dikenal dengan Analisis rasio koperasi dengan menggunakan Analisis rasio perputaran kredit dan rasio rentabilitas ekonomi.Hasil penelitian menunjukkan bahwa Tingkat perputaran rentabilitas selama kurun waktu tahun 2014 sampai dengan tahun 2018 terus mengalami peningkatan yang signifikan yaitu diatas 100% kecuali Pada tahun 2015 yaitu sebesar 98,92%. Tingkat perputaran kredit mengalami peningkatan setiap tahunnya yaitu mulai tahun 2014 sampai dengan tahun 2018 bahwa rata-rata perputaran kredit dalam setahun seperti yang dianalisis dengan menggunakan rumus perputaran (RTO) mengalami perputaran di atas seribu kali.
DAMPAK PANDEMI COVID-19 TERHADAP PENDAPATAN EKONOMI PEDAGANG KECIL DI KELURAHAN JATIBARU KECAMATAN ASAKOTA KOTA BIMA
Authors: Arsad Arsad , Burhanuddin Burhanuddin 
Published: May 2022

Covid-19 merupakan jenis virus yang penyebarannya sangat cepat sekali, bisa tertular dari manusia ke manusia dari sistem pernapasan atau droplet. Beberapa Negara banyak memberlakukan lockdown, dengan tujuan memutus rantai penularan Covid-19. Menyebabkan jalur perekonomian terhambat dan menyebabkan perekonomian dunia porak-poranda, tidak terlepas pula perekonomian Negara Indonesia. Salah satu sektor ekonomi yang sangat berdampak oleh pandemi Covid-19 adalah sektor Pedagang Kecil. Peneliti mengambil judul dampak pandemi Covid-19 terhadap pendapatan ekonomi pedagang kecil di Kelurahan Jatibaru Kecamatan Asakota Kota Bima. Rumusan masalah yang di teliti adalah Bagaimana dampak pandemi Covid-19 terhadap pendapatan ekonomi pedagang kecil di Kelurahan Jatibaru Kecamatan Asakota Kota Bima? Tujuan Penelitian yang akan di teliti adalah untuk Mengetahui Bagaimanakah dampak pandemic covid-19 terhadap pendapatan ekonomi pedagang kecil di Kelurahan Jatibaru, Kecamatan Asakota, Kota Bima.
Penelitian ini adalah penelitian kualitatif dengan pendekatan deskriptif. Untuk mendapatkan data yang diperlukan maka dilakukan penelitian dengan cara mewawancarai pedagang, setelah data-data diperoleh maka dilakukan pengujian dengan menggunakan teknik analisis data kualitatif.
Berdasarkan hasil penelitian dan pembahasan maka kesimpulan yang penulis simpulkan adalah selama tersebarnya pandemic covid-19 yang berpengaruh negative dan kalau dipersentasikan ada sebanyak 73% yang mengeluh karena pelanggan berkurang, ada 46% yang mengeluh karena kesulitan dalam mendapatkan modal usaha dan ada 40% yang mengeluh karena tidak bisa menerima pelanggan ditempat seperti biasa. PPKM (Pemberlakuan pembatasan kegiatan masyarakat) membuat banyak outlet yang jam operasionalnya dikurangi, apalagi semenjak masyarakat disuruh dirumah aja mereka lebih banyak memilih untuk mengurangi aktivitas di luar sehingga para pedagang kecil ini mengalami kerugian akibat berkurangnya pembeli dan menurunya pendapatan.
Comprehensive Analyses of MELK-Associated ceRNA Networks Reveal a Potential Biomarker for Predicting Poor Prognosis and Immunotherapy Efficacy in Hepatocellular Carcinoma
Authors: Liu Yu , Li Rongkuan , Wang Xiaobo , Xue Zuguang , Yang Xiaozhou , Tang Bo 
Published: May 2022

Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world with high morbidity and mortality. Identifying specific molecular markers that can predict HCC prognosis is extremely important. MELK has been reported to play key roles in several types of human cancers and predict poor prognosis. This study was aimed to explore the impact of MELK on HCC.Methods: A pan-cancer analysis of MELK was conducted by The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) data. The prognosis of MELK in various cancers was analyzed in GEPIA. Then, a ceRNA network of MELK was constructed based on the comprehensive consideration of the expression analysis, the correlation analysis, and the survival analysis by R software. The correlation of MELK and immune cell infiltration was analyzed by TIMER and ﻿CIBERSORT. Then, the overall survival of differentially expressed immune cells was conducted. The correlation of MELK and immune checkpoints expression was analyzed by GEPIA.Results: MELK was overexpressed in 14 types of human cancers, and its expression was significantly higher than that in both unmatched and paired normal samples in HCC. Higher MELK expression was correlated with poorer survival and advanced clinical stage, topography (T) stage, and histological grade. The univariate and multivariate Cox regression analyses showed that MELK was an independent risk factor for poor prognosis in HCC. Then, we constructed a ceRNA network consisting of MELK, miR-101-3p, and two lncRNAs (SNHG1 and SNHG6) after evaluating the expression and impact on prognosis in HCC of these RNAs. TIMER and CIBERSORT databases indicated that MELK was correlated with various immune cells including B cells, CD8+ T cells, CD4+ T cells, macrophage, neutrophil, and dendritic cells in HCC. Of them, B cells, CD4+ T cells, macrophage, and neutrophil were related to the prognosis of HCC. In addition, MELK was significantly positively correlated with the immune checkpoint genes.Conclusions: MELK may be a novel potential biomarker for predicting prognosis and immunotherapy efficacy in patients with HCC. Our study may provide new molecular and therapeutic strategies for the treatment of HCC patients.
Relationship of Soluble Klotho and Early Stage of Diabetic Nephropathy: A Systematic Review and Meta-Analysis
Authors: Xin Caihong , Sun Xin , Li Zheng , Gao Tianshu 
Published: May 2022

BackgroundDiabetic nephropathy (DN) is a chronic microvascular complication caused by long-term hyperglycemia in patients with diabetes and an important cause of end-stage renal disease. Although some studies have shown that soluble Klotho(sKlotho) levels of patients with DN are lower than those without DN, in the early stage of patients with DN with normal renal function and albuminuria, the change in sKlotho is still controversial.AimThis meta-analysis was conducted to statistically evaluate sKlotho levels in patients with DN.MethodsWe searched the following electronic databases: Web of Science, Embase, PubMed, Google Scholar, and China National Knowledge Infrastructure (CNKI). The following search terms were used for the title or abstract: “diabetic kidney disease”, “diabetic nephropathy”, OR “DN” in combination with “Klotho”. The meta-analysis results were presented as standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs).ResultsFourteen articles were included in the meta-analysis. In our meta-analysis, we found that the sKlotho level in patients with DN was significantly lower than that in patients without DN (SMD: -1.52, 95% CI [-2.24, -0.80]), and it was also significantly lower in the early stage of DN (SMD: -1.65, 95% CI [-2.60, -0.70]).ConclusionsThis systematic review was the first to evaluate the relationship between sKlotho levels and DN. The sKlotho level was significantly lower in the early stages of DN, indicating that sKlotho might be a new biomarker of DN in the future.
Extended-Range Forecasting of PM2.5 Based on the S2S: A Case Study in Shanghai, China
Authors: Qu Yuanhao , Ma Jinghui , Yu Zhongqi 
Published: May 2022

Air pollution has become one of the most challenging problems in China, especially in economically developed and densely populated regions such as Shanghai. In this study, the long short-term memory (LSTM) model is introduced for the application in extended-range forecasting of PM2.5 in Shanghai by incorporating three members of the Subseasonal-to-Seasonal Prediction project (S2S) forecasting, moderate-resolution imaging spectroradiometer (MODIS) aerosol optical depth (AOD) data, and large-scale circulation factors derived from ERA-5 reanalysis. Therefore, an accurate ∼40-day PM2.5 prediction model over Shanghai was developed, providing new insights for air pollution extended-range forecasting. The new model not only exhibited much better accuracy but also captured the pollution process more closely than traditional methods, such as multiple regression (MLR). The prediction root-mean-square errors (RMSEs) based on the China Meteorological Administration (CMA), the U.K. model, and the European Centre for Medium-Range Weather Forecasts (ECMWF) were 24.84, 24.35, and 22.27 μg m−3, respectively, and their Heidke Skill Scores (HSSs) were between 0.1 and 0.5. As a result, the S2S-LSTM model for extension period pollution prediction with higher accuracy developed in this study could further burst the hot spots of pollution extended-range prediction research. However, limitations of the prediction model are still in existence, especially in dealing with only a single site instead of a two-dimensional prediction, which requires further investigation in future studies.
The Investigation of Hepatitis B Vaccine Immune Responses in Occult Hepatitis B Virus-Infected Patients
Authors: Peng Jing , Yao Xueying , Yuan Chunyan , Liu Xiaoli , Xia Renxiang , He Jian , Li Rui , Yao Yunqing 
Published: May 2022

ObjectivesThere is no effective treatment for occult hepatitis B virus infection (OBI) patients, and immunotherapy may be one of the most promising options. We aim to investigate the underlying mechanism and therapeutic potential of hepatitis B vaccine immunotherapy for OBI patients.MethodsOutpatient OBI patients were screened and randomly divided into treatment (Group A) and control (Group B) groups. At weeks 0, 4, and 24, patients in Group A received a subcutaneous/intramuscular injection of hepatitis B vaccine (Engerix-B, 20 μg/time) according to the standard vaccination schedule; patients in Group B served as blank control. The patients were followed for 36 weeks, with clinical, biochemical, virological, immunological, and imaging data collected and analyzed at weeks 0, 12, 24, and 36, respectively, and the relation between the virology and immunology results was analyzed.ResultsOf the 228 OBI patients, 28 were excluded, and 200 were enrolled for observation. In the end, 44 patients were included in Group A and 39 in Group B after excluding lost cases. At week 0 (baseline), some patients in two groups had liver disease symptoms, HBV-related liver function damage, and liver fibrosis. 86.36% (38/44) and 82.05% (32/39) patients were positive for serum hepatitis B surface antibodies (anti-HBs) in Group A and Group B, respectively, with the median (quartile) of 42.47 (16.85, 109.1) and 39.27 (16.06, 117.4) mIU/ml, respectively. Reduced peripheral blood CD4+T, CD8+T, and B lymphocytes were found in some patients in two groups. These results were not statistically different between Group A and Group B (P&gt;0.05). At week 36, all patients were serum anti-HBs (+) in Group A, with a median (quartile) of 1000 (483.9, 1000) mIU/ml, which was significantly higher than that at week 0 (P&lt;0.05) and that in Group B (P&lt;0.05). Compared to week 0, the number of CD8+ T and B lymphocytes increased significantly and were significantly higher than Group B at the same point. Two patients in Group B were found to have hepatitis B virus reactivation from week 12 to week 36.Correlation AnalysisAnti-HBs in Group A patients were positively correlated with B lymphocytes (r=0.3431, 0.3087, and 0.3041, respectively) and positively correlated with CD8+ T lymphocytes (r=0.4954, 0.3054, and 0.3455, respectively) at weeks 12, 24, and 36.ConclusionVirological reactivation is a risk for OBI patients. Serum hepatitis B surface antibodies were significantly increased after hepatitis B vaccine treatment, the same as the numbers of peripheral blood B and CD8+ T lymphocytes; changes in hepatitis B surface antibody levels were positively correlated with the changes in peripheral blood B and CD8+ T lymphocytes.
Mercurial Contamination: A Consumer Health Risk Assessment Concerning Seafood From a Eutrophic Estuary in Southeastern Brazil
Authors: Rodrigues Paloma de Almeida , Ferrari Rafaela Gomes , Rosário Denes Kaic Alves do , Hauser-Davis Rachel Ann , Santos Luciano Neves dos , Conte-Junior Carlos Adam 
Published: May 2022

Mercury (Hg) contamination has increased in the last decades, resulting in human consumption concerns mainly in developing countries. In this context, this study aimed to carry out a health risk assessment regarding the consumption of swimming crabs, shrimp and squid species caught in different regions of the Guanabara Bay, Rio de Janeiro, Brazil. For this purpose, we used calculations that indicated the Estimated Monthly Intake (EMI), Maximum Monthly Intake Rate (IRmm) and Hazard Quotient (HQ). As the target population, the mean weight corresponding to men and women children aged 12 years, young people aged 24 years, and middle-aged people (adults) aged 54 years were used, taking into account the female and male gender. In the studied seafood, the EMI (0.0001 to 0.0006 mg.kg.month-1) was below the monthly intake limit and IRmm (10.3 to 34.8 kg month-1) indicates that large quantities of seafood can be consumed by the population studied, unless the safe limit of monthly intake of the contaminant is reached. The hazard quotient (0.4 to 1.4) indicate potential risks health of children eating swimming crabs and squid and young women eating swimming crabs. Our study also highlights the importance of risk assessments, as even when seafood contains Hg concentrations below established limits, consumption variables must be taken into account, so as not to underestimate the potential health risks.
Increased Stiffness of the Superficial Cervical Extensor Muscles in Patients With Cervicogenic Headache: A Study Using Shear Wave Elastography
Authors: Lin Li-Zhen , Yu Yan-Ni , Fan Jie-Cheng , Guo Pei-Wu , Xia Chun-Feng , Geng Xue , Zhang Shu-Yun , Yuan Xiang-Zhen 
Published: May 2022

BackgroundCervicogenic headache (CEH) is a secondary headache caused by lesions of the cervical spine and surrounding soft tissues. Cervical muscle dysfunction may be related to the onset of CEH. However, whether cervical muscle stiffness changes in patients with CEH has not been well studied. The purpose of this study was to explore changes in superficial cervical extensor muscle stiffness in patients with CEH using shear wave elastography (SWE).MethodsIn this study, 19 patients with CEH and 20 healthy controls were recruited. Superficial cervical extensor muscle stiffness was obtained from SWE, and the SuperLinear SL10-2 MHz linear array probe in the musculoskeletal muscle mode was chosen as the transducer. Regions of interest in the trapezius (TRAP), splenius capitis (SPL), semispinalis capitis (SCap), and semispinalis cervicis (SCer) were manually segmented. Correlations between superficial cervical extensor muscle stiffness and visual analog scale (VAS) scores, age, and body mass index (BMI) were analyzed using Pearson's correlation. Receiver operating characteristic (ROC) curve was used to investigate the diagnostic ability of superficial cervical extensor stiffness for CEH.ResultsSuperficial cervical extensor muscle stiffness on the headache side of patients with CEH was higher than that on the non-headache side and in healthy controls (p &lt; 0.05). Increased stiffness was also observed in SCer on the non-headache side of patients with CEH compared to healthy controls (p &lt; 0.01). In patients with CEH, SCer stiffness was positively correlated with VAS scores (r = 0.481, p = 0.037), but no correlation was found between other muscles and VAS scores (p &gt; 0.05). The areas under the curve of TRAP, SPL, SCap, and SCer in diagnosing CEH were 0.766, 0.759, 0.964, and 1.000, respectively.ConclusionsIncreased stiffness was observed in the superficial cervical extensor muscles on the headache side of patients with CEH. SCer stiffness was correlated with headache intensity in patients with CEH and may provide clues for the diagnosis of CEH.
Fecal Microbiota Transplantation for Patients With Irritable Bowel Syndrome: A Meta-Analysis of Randomized Controlled Trials
Authors: Zhao Hui-jun , Zhang Xiao-jing , Zhang Na-na , Yan Bin , Xu Ke-ke , Peng Li-hua , Pan Fei 
Published: May 2022

Background:Gut microbiota has been identified as an imbalance in patients with irritable bowel syndrome (IBS). Fecal microbiota transplantation (FMT) is a novel method to restore microbiota and treat IBS patients.ObjectiveTo conduct a meta-analysis and estimate the efficacy and safety of FMT for the treatment of IBS patients with subgroup analyses to explore the most effective way of FMT for IBS.MethodsAll eligible studies were searched from PubMed, Embase, Web of Science, and the Cochrane Library through multiple search strategies. Data were extracted from studies comprising the following criteria: double-blind, randomized controlled trials (RCTs) that compared the efficacy of FMT with placebo for adult patients (≥18 years old) with IBS. A meta-analysis was performed to evaluate the summary relative risk (RR) and 95% confidence intervals (CIs).ResultsA total of seven RCTs comprising 489 subjects were eligible for this meta-analysis. Pooled data showed no significant improvement of global IBS symptoms in patients with FMT compared with placebo (RR = 1.34; 95% CI 0.75–2.41, p = 0.32). A significant heterogeneity was observed among the studies (I2 = 83%, p &lt; 0.00001). There was no significant evidence of funnel plot asymmetry (Egger's test, p = 0.719; Begg's test, p = 1.000), indicating no existence of publication bias. Subgroup analyses revealed that FMT operated by invasive routes, including gastroscope, colonoscope, and nasojejunal tube, significantly improved global IBS symptoms (RR = 1.96; 95% CI 1.23–3.11, p = 0.004) with heterogeneity (I2 = 57%, p = 0.06) and an NNT of 3 (95% CI 2–14). However, FMT delivered via oral capsules showed a negative impact on patients with IBS (RR = 0.56; 95% CI 0.33–0.96, p = 0.03) with a low heterogeneity (I2 = 39%, p = 0.2) and an NNH of 3 (95% CI 2–37).ConclusionThe current evidence from RCTs with all routes of FMT does not show significant global improvement in patients with IBS. However, FMT operated by invasive routes significantly improved global IBS symptoms.