bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated bone healing evaluation: New approach to histomorphometric analysis
Authors: Linhares Camila Rodrigues Borges , Rabelo Gustavo Davi , Limirio Pedro Henrique Justino Oliveira , Venâncio Jessyca Figueira , Ribeiro Silva Igor Gonçalves , Dechichi Paula 
Published: June 2022

AbstractThis study aimed to assess different approaches for bone healing evaluation on histological images and to introduce a new automatic evaluation method based on segmentation with distinct thresholds. We evaluated the hyperbaric oxygen therapy (HBO) effects on bone repair in type 1 diabetes mellitus rats. Twelve animals were divided into four groups (n = 3): non‐diabetic, non‐diabetic + HBO, diabetic, and diabetic + HBO. Diabetes was induced by intravenous administration of streptozotocin (50 mg/kg). Bone defects were created in femurs and HBO was immediately started at one session/day. After 7 days, the animals were euthanized, femurs were removed, demineralized, and embedded in paraffin. Histological sections were stained with hematoxylin and eosin (HE) and Mallory's trichrome (MT), and evaluated using three approaches: (1) conventional histomorphometric analysis (HE images) using a 144‐point grid to quantify the bone matrix; (2) a semi‐automatic method based on bone matrix segmentation to assess the bone matrix percentage (MT images); and (3) automatic approach, with the creation of a plug‐in for ImageJ software. The time required to perform the analysis in each method was measured and subjected to Bland–Altman statistical analysis. All three methods were satisfactory for measuring bone formation and were not statistically different. The automatic approach reduced the working time compared to visual grid and semi‐automated method (p < .01). Although histological evaluation of bone healing was performed successfully using all three methods, the novel automatic approach significantly shortened the time required for analysis and had high accuracy.
Developing an innovative raw wheat Qu inoculated with Saccharopolyspora and its application in Huangjiu
Authors: Ma Donglin , Liu Shuangping , Liu Haipo , Nan Mujia , Xu Yuezheng , Han Xiao , Mao Jian 
Published: June 2022

AbstractBACKGROUNDMechanized Huangjiu is a stable product, is not subject to seasonal production restrictions, and markedly reduces labor intensity compared to traditional manual Huangjiu. However, the bitterness of mechanized Huangjiu impedes its further development.RESULTSBased on process optimization, when the fermentation temperature was 45 °C and the fermentation time was 122 h, the inoculation amount of Saccharopolyspora was 5%, the amount of added water was 26%, and the glucoamylase and amylase activities of wheat Qu increased by 27% and 40% respectively, compared with those before optimization. Huangjiu fermented by raw wheat Qu inoculated with Saccharopolyspora rosea F2014 showed a significant (P < 0.05) decrease in bitter amino acid content (1.24 vs. 2.86 g L−1, a decrease of 56%), which attenuated its bitterness.CONCLUSIONAn innovative fermentation process of inoculating Saccharopolyspora into raw wheat Qu was developed for the first time. Such a process could be used to control bitterness based on raw wheat Qu inoculated with Saccharopolyspora rosea F2014, instead of traditional wheat Qu in Huangjiu fermentation. © 2022 Society of Chemical Industry.
The effect of anthropomorphized technology failure on the desire to connect with others
Authors: Lteif Lama , Valenzuela Ana 
Published: June 2022

AbstractExtant work suggests that unsuccessful human−technology interactions can elicit negative affective reactions, prompting users to engage in compensatory behavior including seeking affiliation with others. The current work presents one mechanism to explain these findings. Specifically, we propose that users may construe incidents of technology failure akin to incidents of social rejection: Across three studies, we demonstrate that when an anthropomorphized (vs. nonanthropomorphized) technology fails to function as expected, users experience feelings of rejection, and subsequently express a greater desire to connect with others. In doing so, we contribute to extant research on human−technology interactions by uniquely demonstrating that feelings of social rejection may arise from technology failure. Our work also deepens our understanding of the unintended negative consequences of product anthropomorphism and, as such, provides insight into technology design.
Long‐Term Dietary Effects on Human Gut Microbiota Composition Employing Shotgun Metagenomics Data Analysis
Authors: Troci Alba , Rausch Philipp , Waschina Silvio , Lieb Wolfgang , Franke Andre , Bang Corinna 
Published: June 2022

ScopeThe gut microbiome regulates various metabolic pathways in the host and its dysbiosis is involved in the pathogenesis of diverse diseases. One of the major factors triggering gut microbiome establishment is diet. This study aims to unravel interactions and changes between diet and gut microbiome over a period of 3 years.Methods and resultsThis study investigates the relation between diet and the microbiome of 75 individuals over a 3‐year time period. Shotgun metagenomic sequencing is performed to profile gut microbial composition and function. This study shows that there are significant changes in gut microbiome taxonomy and functional composition between two time points. Whereas microbial taxonomy is found to be highly individualized, overall microbial functions stay relatively stable. Moreover, in silico metabolic modeling of microbial communities indicates that changes in dietary intake of medium‐chain saturated fatty acids is accompanied by an altered utilization of amino acids by the gut microbiome.ConclusionThe study design allows us to validate functional stability within the gut microbiome of healthy subjects over a 3‐year period. However, enduring changes in nutrition such as increased alcohol consumption or decreased intake of vegetables come along with enhanced microbial functions that are associated with disease etiology.
Collaboration between two CF centers; one in USA and one in Turkey before and during CoV2 pandemic
Authors: Nasr Samya Z. , Gökdemir Yasemin , Erdem Ela , Karakoc Fazilet , Ergenekon Pinar , Tapley Christopher , Dagher Sharyn , Bouma Sandra , Coşkun Özge Keniş , Kocamaz Damla , Karadag Bulent 
Published: June 2022

AbstractTo address the discrepancy in the quality of care and outcomes between cystic fibrosis centers (CFCs) in high‐income countries and limited resources countries (LRCs), a collaboration between our team at the University of Michigan CFC (UMCFC) and a CF center in Turkey (Marmara University CFC [MUCFC], Istanbul) was established. The collaboration included evaluation of all aspects of care and initiation of quality improvement (QI) measures. Teaching and implementing QI tools has led to start of improvement in MUCFC care. Close monitoring and sharing resources like UMCFC algorithms, protocols, and QI processes were done.
Does the routine use of spirometry improve clinical outcomes in children?—A systematic review
Authors: Boonjindasup Wicharn , Chang Anne B. , McElrea Margaret S. , Yerkovich Stephanie T. , Marchant Julie M. 
Published: June 2022

AbstractSpirometry provides a quantitative measure of lung function and its use is recommended as an adjunct to enhance pediatric respiratory healthcare in many clinical practice guidelines. However, there is limited evidence confirming the benefits (or otherwise) of using spirometry from either clinician or patient perspectives. This systematic review aimed to determine the impact of spirometry on change in clinical decision making and patient‐reported outcome measures. We searched PubMed, Embase, Cochrane Central Register of Controlled Trials, www.clinicaltrials.gov, and World Health Organization International Clinical Trials Registry Platform, from inception to July 2021. We included randomized controlled trials (RCTs) comparing the use versus non‐use of spirometry during standard clinical review in children aged <18 years with respiratory problems in clinics. We used Cochrane methodology. The search identified 3475 articles; 8 full‐text articles were reviewed but only 1 study fulfilled the inclusion criteria. The single study involved two cluster RCTs of spirometry for children with asthma in general practice. The included study did not find any significant intergroup difference at the 12‐month follow‐up for asthma‐related quality‐of‐life and clinical endpoints. However, the findings were limited by methodological weaknesses and high risks of bias. With a paucity of data, the clinical benefits of spirometry remain unclear. Thus, there is a clear need for RCTs that provide high‐quality evidence to support the routine use of spirometry in children with suspected or known lung disease. Pending the availability of better evidence, we recommend that clinicians adhere to the current clinical practice recommendations.
Win statistics (win ratio, win odds, and net benefit) can complement one another to show the strength of the treatment effect on time‐to‐event outcomes
Authors: Dong Gaohong , Huang Bo , Verbeeck Johan , Cui Ying , Song James , Gamalo‐Siebers Margaret , Wang Duolao , Hoaglin David C. , Seifu Yodit , Mütze Tobias , Kolassa John 
Published: June 2022

AbstractConventional analyses of a composite of multiple time‐to‐event outcomes use the time to the first event. However, the first event may not be the most important outcome. To address this limitation, generalized pairwise comparisons and win statistics (win ratio, win odds, and net benefit) have become popular and have been applied to clinical trial practice. However, win ratio, win odds, and net benefit have typically been used separately. In this article, we examine the use of these three win statistics jointly for time‐to‐event outcomes. First, we explain the relation of point estimates and variances among the three win statistics, and the relation between the net benefit and the Mann–Whitney U statistic. Then we explain that the three win statistics are based on the same win proportions, and they test the same null hypothesis of equal win probabilities in two groups. We show theoretically that the Z‐values of the corresponding statistical tests are approximately equal; therefore, the three win statistics provide very similarp‐values and statistical powers. Finally, using simulation studies and data from a clinical trial, we demonstrate that, when there is no (or little) censoring, the three win statistics can complement one another to show the strength of the treatment effect. However, when the amount of censoring is not small, and without adjustment for censoring, the win odds and the net benefit may have an advantage for interpreting the treatment effect; with adjustment (e.g., IPCW adjustment) for censoring, the three win statistics can complement one another to show the strength of the treatment effect. For calculations we use the R package WINS, available on the CRAN (Comprehensive R Archive Network).
Real‐Time Feedback‐Driven Single‐Particle Tracking: A Survey and Perspective
Authors: van Heerden Bertus , Vickers Nicholas A. , Krüger Tjaart P. J. , Andersson Sean B. 
Published: June 2022

AbstractReal‐time feedback‐driven single‐particle tracking (RT‐FD‐SPT) is a class of techniques in the field of single‐particle tracking that uses feedback control to keep a particle of interest in a detection volume. These methods provide high spatiotemporal resolution on particle dynamics and allow for concurrent spectroscopic measurements. This review article begins with a survey of existing techniques and of applications where RT‐FD‐SPT has played an important role. Each of the core components of RT‐FD‐SPT are systematically discussed in order to develop an understanding of the trade‐offs that must be made in algorithm design and to create a clear picture of the important differences, advantages, and drawbacks of existing approaches. These components are feedback tracking and control, ranging from simple proportional‐integral‐derivative control to advanced nonlinear techniques, estimation to determine particle location from the measured data, including both online and offline algorithms, and techniques for calibrating and characterizing different RT‐FD‐SPT methods. Then a collection of metrics for RT‐FD‐SPT is introduced to help guide experimentalists in selecting a method for their particular application and to help reveal where there are gaps in the techniques that represent opportunities for further development. Finally, this review is concluded with a discussion on future perspectives in the field.
Controllable Synthesis of Ultrathin Defect‐Rich LDH Nanoarrays Coupled with MOF‐Derived Co‐NC Microarrays for Efficient Overall Water Splitting
Authors: Guo Tongtian , Chen Liyu , Li Yingwei , Shen Kui 
Published: June 2022

AbstractWater electrolysis has attracted immense research interest, nevertheless the lack of low‐cost but efficient bifunctional electrocatalysts for both hydrogen and oxygen evolution reactions greatly hinders its commercial applications. Herein, the controllable synthesis of ultrathin defect‐rich layered double hydroxide (LDH) nanoarrays assembled on metal‐organic framework (MOF)‐derived Co‐NC microarrays for boosting overall water splitting is reported. The Co‐NC microarrays can not only provide abundant nucleation sites to produce a large number of LDH nuclei for favoring the growth of ultrathin LDHs, but also help to inhibit their tendency to aggregate. Impressively, five types of ultrathin bimetallic LDH nanoarrays can be electrodeposited on the Co‐NC microarrays, forming desirable nanoarray‐on‐macroarray architectures, which show high uniformity with thicknesses from 1.5 to 1.9 nm. As expected, the electrocatalytic performance is significantly enhanced by exploiting the respective advantages of Co‐NC microarrays and ultrathin LDH nanoarrays as well as the potential synergies between them. Especially, the optimal Co‐NC@Ni2Fe‐LDH as both cathode and anode can afford the lowest cell voltage of 1.55 V at 10 mA cm‐2, making it one of the best earth‐abundant bifunctional electrocatalysts for water electrolysis. This study provides new insights into the rational design of highly‐active and low‐cost electrocatalysts and facilitates their promising applications in the fields of energy storage and conversion.
Assessment of Cell–Material Interactions in Three Dimensions through Dispersed Coaggregation of Microsized Biomaterials into Tissue Spheroids
Authors: Fois Maria G. , Tahmasebi Birgani Zeinab N. , Guttenplan Alexander P. M. , Blitterswijk Clemens A. van , Giselbrecht Stefan , Habibović Pamela , Truckenmüller Roman K. 
Published: June 2022

AbstractIn biomaterials R&D, conventional monolayer cell culture on flat/planar material samples, such as films, is still commonly employed at early stages of the assessment of interactions of cells with candidate materials considered for a biomedical application. In this feasibility study, an approach for the assessment of 3D cell–material interactions through dispersed coaggregation of microparticles from biomaterials into tissue spheroids is presented. Biomaterial microparticles can be created comparatively quickly and easily, allow the miniaturization of the assessment platform, and enable an unhindered remodeling of the dynamic cell–biomaterial system at any time. The aggregation of the microsized biomaterials and the cells is supported by low‐attachment round‐bottom microwells from thin polymer films arranged in densely packed arrays. The study is conducted by the example of MG63 osteoblast‐like and human mesenchymal stem/stromal cells, and a small library of model microbiomaterials related to bone repair and regeneration. For the proof of concept, example interactions including cell adhesion to the material, the hybrid spheroids’ morphology, size, and shape, material‐associated cell death, cell metabolic activity, cell proliferation, and (osteogenic) differentiation are investigated. The cells in the spheroids are shown to respond to differences in the microbiomaterials’ properties, their amounts, and the duration of interaction with them.
Mechanically Induced Highly Efficient Hydrogen Evolution from Water over Piezoelectric SnSe nanosheets
Authors: Li Shun , Zhao Zhicheng , Li Jiabin , Liu Hong , Liu Maosong , Zhang Yuqiao , Su Lizhong , Pérez‐Jiménez Ana Isabel , Guo Yunchang , Yang Fan , Liu Yong , Zhao Jinzhu , Zhang Jianming , Zhao Li‐Dong , Lin Yuanhua 
Published: June 2022

AbstractPiezoelectric nanomaterials open new avenues in driving green catalysis processes (e.g., H2 evolution from water) through harvesting mechanical energy, but their catalytic efficiency is still limited. The predicted enormous piezoelectricity for 2D SnSe, together with its high charge mobility and excellent flexibility, renders it an ideal candidate for stimulating piezocatalysis redox reactions. In this work, few‐layer piezoelectric SnSe nanosheets (NSs) are utilized for mechanically induced H2 evolution from water. The finite elemental method simulation demonstrates an unprecedent maximal piezoelectric potential of 44.1 V for a single SnSe NS under a pressure of 100 MPa. A record‐breaking piezocurrent density of 0.3 mA cm−2 is obtained for SnSe NSs‐based electrode under ultrasonic excitation (100 W, 45 kHz), which is about three orders of magnitude greater than that of reported piezocatalysts. Moreover, an exceptional H2 production rate of 948.4 µmol g−1 h−1 is achieved over the SnSe NSs without any cocatalyst, far exceeding most of the reported piezocatalysts and competitive with the current photocatalysis technology. The findings not only enrich the potential piezocatalysis materials, but also provide useful guidance toward high‐efficiency mechanically driven chemical reactions such as H2 evolution from water.
Self‐Templating‐Oriented Manipulation of Ultrafine Pt3Cu Alloyed Nanoparticles into Asymmetric Porous Bowl‐Shaped Configuration for High‐Efficiency Methanol Electrooxidation
Authors: Zhang Zhenbo , Li Jing , Liu Shuyun , Zhou Xue , Xu Lin , Tian Xinlong , Yang Jun , Tang Yawen 
Published: June 2022

AbstractThe precise and comprehensive manipulation of the component, size, and geometric nano‐architecture of platinum‐based electrocatalysts into porous and hollow structure can effectively impart the catalysts with substantially improved electrochemical performance, yet remain formidably challenging. Herein, a straightforward fabrication of porous platinum‐copper alloyed nanobowls (abbreviated as Pt3Cu NBs hereafter) assembled by ultrafine nanoparticles (≈2.9 nm) via a one‐pot hydrothermal approach with the assistance of a structure‐directing agent of N,N′‐methylenebisacrylamide (MBAA) is reported. The involvement of MBAA plays a decisive role in the formation of Pt‐MBAA complex solid nanospheres, which serve as the self‐sacrificial reactive template for the deposition/growth of Pt3Cu nanoparticles and the eventual formation of the asymmetric open‐shelled nanobowls. Benefitting from the 3D sufficient accessibility of exterior/interior surfaces, high atom‐utilization efficiency, and PtCu bimetallic alloy synergy, the self‐supported Pt3Cu NBs demonstrate remarkably enhanced activity, better anti‐poisoning capability, and reinforced robustness for the methanol oxidation reaction (MOR) as compared with the commercial Pt black benchmark, exhibiting great application promises in practical fuel cell systems. It is envisaged that the innovative self‐templated synthetic strategy outlined here may provide a perspective to design a range of porous bowl‐shaped high‐performance nanocatalysts.
Tailored Inorganic‐Organic Architectures via Metalloligands
Authors: Pachisia Sanya , Gupta Rajeev 
Published: June 2022

AbstractThis article discusses the design principles and strategies and the structural outcome of various supramolecular architectures constructed by utilizing well‐defined coordination complexes as the metalloligands. We have included selected examples of metalloligands, offering either pyridyl or arylcarboxylic acid groups as the appended functional groups, for illustrating the construction of their supramolecular architectures. Both geometrical position and the number of the appended functional groups emerging from a metalloligand were found to critically regulate the structural aspects and dimensionality of the resultant material. The article concludes by delineating the structure‐directing lessions as well as the potential applications of the metalloligand‐based supramolecular architectures for the generation of next‐level materials.
Elemental Two‐Dimensional Materials for Li/Na‐Ion Battery Anode Applications
Authors: Tian Yahui , Chen Ya , Liu Yaoda , Li Hui , Dai Zhengfei 
Published: June 2022

AbstractTwo‐dimensional (2D) nanostructure is currently the subject in the fields of new energy storage and devices. During the past years, a broad range of 2D materials represented by graphene have been developed and endow with excellent electrochemical properties. Among them, elemental 2D materials (Xenes) are an emerged material family for Li/Na‐ion battery (LIB/SIB) anodes. Compared with other 2D materials and bulk materials, Xenes may exhibit some great superiorities for Li/Na storage, including excellent conductivity, fast ion diffusion and large active sites exposure. In this review, we provide a systematic summary of the recent progress and achievements of Xenes as well as their applications in LIBs/SIBs. The broad categorization of Xenes from group IIIA to VIA has been concisely outlined, and the related details in syntheses, structures and Li/Na‐ion storage properties are reviewed. Further, the latest research progress of Xenes in Li/Na ion batteries are summarized, together with mechanism discussions. Finally, the challenges and prospects of Xenes applied to Li/Na ion battery are proposed based on its current developments.
Glocality Is the Current State of the Art
Authors: Mihr Anja 
Published: June 2022

AbstractExogenous and endogenous dynamics and factors determine the level of glocality, and the practice of glocal governance. Climate change, digitalization, and urbanization, the rise of non-state actors and erosion of statehood, and in many cases dysfunctional governments, are calling for a more participatory and multi-stakeholder driven form of governance. Other modes of governance such as public–private partnership engage public and private actors to realize glocal governance. Global mobility will increase, both virtual and in person, and hence people will move in spaces and in territories without clear boundaries, laws, and limits. Glocal governance give guidelines and rules how to organize communities in this borderless world.