bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utility of a Clinically Guided Data-Driven Approach for Predicting Breast Cancer Complications: An Application Using a Population-Based Claims Data Set
Authors: Pichardo Daniel , Michael Russ , Mercer Michele , Korina Natalia , Onukwugha Eberechukwu 
Published: November 2022

PURPOSE With earlier detection and an increasing number of breast cancer (BCa) survivors, more women are living with side effects of BCa treatment. A predictive approach to studying treatment-related adverse events (AEs) may generate proactive strategies; however, many studies are descriptive in nature. Focusing on short-term AEs, we determine the performance of prediction models of disease- or treatment-related AEs among women diagnosed with BCa. METHODS We used administrative claims data from the Blue Health Intelligence National Data Repository. The study sample included female individuals age 18 years and older who were diagnosed with BCa and received cancer-directed treatment between January 1, 2014, and August 1, 2019. Using the information available in the claims data, we constructed longitudinal patient histories and identified disease- and treatment-related AEs occurring within 6 months of treatment. The following prediction models were developed: logistic regression, Lasso regression, gradient boosted tree (GBT), and random forest (RF). We compared models using the area under the receiver operating characteristic curve and its CI, among other metrics. RESULTS Data were extracted for 267,473 members meeting study inclusion criteria. The area under the curve for the logistic regression model was 0.82 (0.82-0.86), compared with 0.89 (0.87-0.90) for the Lasso, 0.91 (0.89-0.93) for the GBT, and 0.90 (0.93-0.89) for the RF models. The sensitivity was 0.96 for the GBT, Lasso, and RF models, whereas the specificity was 0.42, 0.44, and 0.39 for the GBT, Lasso, and RF models, respectively. Positive predictive values were 0.96 across all three models. CONCLUSION Prediction models developed using big data methods and grounded in a clinically guided framework have the potential to reliably predict short-term treatment-related AEs among women diagnosed with BCa.
Effects of paroxetine hydrochloride combined with idebenone on inflammatory factors and antioxidant molecules in treatment of depression after ischemic stroke
Authors: Yuan Li-li , Chen Tian-yu , Huang Zhi-qiang 
Published: November 2022

Objectives: To evaluate the effects of paroxetine hydrochloride combined with idebenone on inflammatory factors and antioxidant molecules in the treatment of depression after ischemic stroke.
Methods: Randomized controlled trial was adopted on 80 patients with depression after ischemic stroke were randomly divided into two groups, with 40 patients in each group at Xingtai Sanli Health Quannan Clinic from March 17, 2019 to December 20, 2021. Both groups were given basic treatment. On this basis, the control group was treated with paroxetine hydrochloride, while the study group was treated with paroxetine hydrochloride combined with idebenone. The clinical efficacy was evaluated using the Hamilton Rating Scale for Depression (HRSD) before and after treatment. Additionally, the difference in HRSD score after treatment and the improvement in inflammatory factors and antioxidant molecules were compared and analyzed between the two groups.
Results: After treatment, the HRSD score of the study group was significantly improved compared with that of the control group (p= 0.00). The effective rate was 82.5% in the study group, which was significantly higher than 62.5% in the control group (p= 0.04). After treatment, TNF-a, CRP and IL-6 in the study group were significantly lower than those in the control group (p= 0.00). Serum SOD, TAC and CAT levels in the study group were significantly higher than those in the control group after treatment (SOD and TAC, p= 0.00; CAT, p= 0.01). The incidence of adverse reactions was 37.5% in the study group and 25% in the control group. Although the incidence of adverse reactions in the study group was higher than that in the control group, the difference was not statistically significant (p= 0.23).
Conclusion: Paroxetine hydrochloride combined with idebenone in the treatment of depression after ischemic stroke can significantly improve HRSD score, enhance clinical efficacy, reduce the levels of inflammatory factors, and increase the levels of antioxidant factors, without a significant increase in adverse reactions. Therefore, it is a safe and effective treatment method.
doi: https://doi.org/10.12669/pjms.39.1.5679
How to cite this: Yuan L, Chen T, Huang Z. Effects of paroxetine hydrochloride combined with idebenone on inflammatory factors and antioxidant molecules in treatment of depression after ischemic stroke. Pak J Med Sci. 2023;39(1):---------. doi: https://doi.org/10.12669/pjms.39.1.5679
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Tumor biology: molecular genetics mechanisms of initiation, promotion and progression
Authors: Ageeva Elizaveta , Golubinskayaa Elena , Makalish Tatyana , Fomochkina Iryna , Kubyshkin Anatolii , Zukow Walery , Shramko Iuliana , Ostapenko Olga , Zhukova Anna , Gurtovaya Anna 
Published: November 2022

For all tumors, regardless of type and tissue, there are a number of common features. These include high proliferative activity, disturbances in the mechanisms of apoptosis and "invisibility" for the cells of the immune system. At the basis of all these disorders lies a malfunction in the interaction between signaling proteins inside the cell, due to a violation of the expression of genes responsible for their synthesis. The aim of the review is to study the molecular biological mechanisms of carcinogenesis, characteristics and features of tumor cells that affect the development of the disease, progression, drug resistance and clinical results and the possibilities of targeted therapy of oncological diseases. Material and methods. The search for literature sources was carried out using PubMed, CyberLeninka, eLibrary, Google Scholar databases; the search depth was 15 years. Results. Recent works have shown the evolution of views on the classification of tumors from the point of view of the mechanisms of damage to the processes of cellular regulation and histogenesis, as well as the development of the modern theory of carcinogenesis, ideas about the mechanisms of development of tumor diseases and the prospects of modern therapies. Conclusion. The study of molecular biological mechanisms of carcinogenesis, characteristics and features of tumor cells is not only fundamental, but also of applied importance in order to predict the development of the disease, progression, drug resistance, clinical results and the possibilities of targeted therapy.
Exploration of delirium assessment and management in a hospice inpatient unit
Authors: Arnold Elizabeth , Fairfield Catherine , Spiller Juliet A , Finucane Anne M 
Published: November 2022

Background:Delirium is common across all palliative care settings. Guidelines exist to support the care of terminally ill people who develop delirium; yet the evidence base is limited. Recent surveys of palliative care specialists have suggested clinical practice is variable.Aim:To explore delirium assessment and management in a hospice inpatient setting.Methods:A mixed-methods study comprising a retrospective case note review of 21 patients admitted to a hospice inpatient unit and semi-structured interviews with seven hospice inpatient doctors and nurses.Results:A total of 62% of patients were screened for delirium on admission using the 4 As tool (4AT). The period prevalence of delirium was 76% during the 2-week study period. The term ‘delirium’ was documented infrequently in case notes, compared to other more ambiguous terms. Interview data suggested that nurses were unfamiliar with delirium screening tools.Conclusion:Lack of awareness about delirium screening tools and the infrequent use of the term ‘delirium’ may suggest that delirium goes under-recognised and under-treated. Further education and research are required to support the care of terminally ill people with delirium.
Examining the mother's supportive role caring for a child with cancer
Authors: Mazhari Fariba , Heidari Shahin , Iranmanesh Sedigheh , Sabzevari Sakineh 
Published: November 2022

Background: Childhood cancer is a stressful experience for patients and their families; it has a profound effect on families emotionally, psychologically and financially. The mother's supportive role affects the child's treatment outcomes and the health of all family members. Aims: This study was conducted to describe the experiences of mothers of children with cancer. Methods: A total of 14 mothers of children with cancer were recruited using purposive sampling. In-depth semi-structured interviews were conducted using a qualitative inductive content analysis. Data were analysed using Graneheim et al's (2004) approach. Findings: According to data analysis, the mother's supportive role can be depicted across four subthemes: ‘being genuinely present with a sick child'; ‘keeping the family together and strengthening its cohesion'; ‘providing compassionate collaborative care for peers'; and ‘empowering the self and taking charge of one's own life'. The main overarching theme extracted from this study was ‘sacrifice'. Conclusion: This study results suggest that the mothers’ supportive role is relying on their own personal power, in which they not only give the care to the child, family and counterparts, but also drive personal growth and empowerment of mothers. A deeper understanding of mothers’ experiences of their supportive role may enhance the quality of care and promote further paediatric approaches to palliative care.
Accessibility and disability inclusion among top-funded U.S. Undergraduate Institutions
Authors: Campanile Jessica , Cerilli Caroline , Varadaraj Varshini , Sweeney Fiona , Smith Jared , Zhu Jiafeng , Yenokyan Gayane , Swenor Bonnielin K. 
Published: November 2022

Background
There is limited data to assess, track, or quantify accessibility and disability inclusion across universities.

Objective
This cross-sectional study assessed disability inclusion and accessibility at the top 50 National Institutes of Health (NIH)-funded undergraduate programs in the United States. We hypothesized that there is no association between NIH funding and the University Disability Inclusion Score.

Methods
A novel tool, the University Disability Inclusion Score assessed disability inclusion and accessibility using 10 indicators spanning 4 categories: (1) accessibility of built and virtual environment, (2) public image of disability inclusion, (3) accommodations processes and procedures, and (4) grievance policy. Based upon the total points (out of a total score of 100), each university was assigned a letter grade (A-F).

Results
Of the top 50 NIH-funded institutions, 6% received an A grade on the Score, while 60% received D or F. The mean scores were 15.2 (SD = 5) for accessibility of built and virtual environment (20 points), 10 (SD = 3) for public image of disability inclusion (20 points), 30.6 (SD = 10) for accommodations processes and procedures (50 points), and 8.1 (SD = 3) for grievance policy (10 points).

Conclusions
Our findings suggest room for improvement in disability inclusion and accessibility among top university recipients of NIH funding. To provide an equitable academic experience, universities must prioritize disability inclusion.
INITIATIVE PROJECTS AS ONE OF THE PROMISING FORMS OF CIVIL PARTICIPATION IN RESOLUTION OF ISSUES OF SOCIO-ECONOMIC DEVELOPMENT OF THE TERRITORY (BY THE MATERIALS OF THE ALTAI TERRITORY)
Authors: Mischenko V. V. , Lyakisheva V. G. , Kirillov A. A. 
Published: November 2022

In the article, in the context of the topic of socio-economic development of the territory, the mechanism for introducing a new and promising form of citizens» participation in solving issues of local importance — initiative projects is considered. They involve providing the population of municipalities with the opportunity to develop and put forward for consideration by the authorities their own projects aimed at improving and developing their place of residence. Initiative projects contribute to the strengthening of trusting relations between the population and authorities, their mutually beneficial cooperation, more rational use of budgetary funds, the growth of residents» interest in improving the comfort of the micro-territory, the emergence of new and more effective approaches to solving common pressing issues.
The authors consider the legal and organizational foundations for the implementation of initiative projects, give practical examples confirming the importance of real interaction between the authorities and the population in the course of the process under study. The role of the population in shaping the practice of initiative budgeting and the need to introduce new forms of involving citizens in local problems are emphasized. Attention is focused on the relevance of involving residents in a specific management process and increasing the interest of all its participants in the final result of joint activities.
COMPARATIVE ASSESSMENT OF THE BUSINESS SECTOR IN RUSSIA AND FINLAND
Authors: Moroshkina M. V. , Utitsyna M. N. 
Published: November 2022

The presented article investigates the aspects of development of social entrepreneurship within the border territories of Russia and Finland. The aim of the study is to assess the opportunities and prospects for the development of socially oriented business. The object of the study is the consumers of the service sector in Russia and Finland.
The method of research is a questionnaire survey, as a result of which the formed questions provide information about the development of the entrepreneurial sector. The study analyzes the needs and opportunities for the development of social entrepreneurship in the border areas. The evaluation of the development of social entrepreneurship is based on focus groups method.
As a result of the conducted research the differences in separate directions of development of entrepreneurial sector in the Republic of Karelia and Finland were revealed. The differences in the expectations of young people in the countries under consideration and the fears of Russian and Finnish respondents were determined. The obtained results allow us to determine the differences in social and economic policy of the states.
THE CONTRIBUTION OF LAND TAX FROM LEGAL ENTITIES TO THE DEVELOPMENT OF THE "GREEN" ECONOMY: THEORY AND PRACTIC
Authors: Chuzmanova S. I. , Chuzmanov A. I. 
Published: November 2022

The rental resources and property potential of land tax on legal persons is not sufficiently represented in economic literature both from the fiscal position of local budgets and in the regulatory context of local green economy. The contribution of land tax on legal persons remains significant for local budgets.
Local budgets land tax on legal persons competentions from the position of local green economy development processes regulation are minimal. The paper goal: researching and definition options and markers of the land tax on legal persons transformation for local green economy development. The theoretical approaches and practice of taxation on lands, statutory instruments content were analyzed. Tax rates and its differentiation were analyzed as taxes regulation instruments. The foreign practice of legal persons lands taxation and its budget efficiency ware analyzed. The significance of the land tax on legal persons was proved as the most stable fiscal instrument of forming local budget income, which are necessary for public goods of territory financing. The problematics of the land tax on legal persons was researched, markers of its improving were pointed. The necessity of tax transforming was substantiated as instrument of local green economy development.
Re-imagining referencing with interactivity
Authors: Schwenger Bettina , Kam Monica , Warner Audrea 
Published: November 2022

As educators we have grappled with strategies to teach referencing, a fundamental of digital information fluency. Despite a myriad of resources, errors are common and recurring (Jorgensen & Marek, 2013). Students frequently receive static information on referencing and no immediate feedback.
This paper reflects on the development and evaluation of online resources for explicitly teaching APA referencing in the Faculties of Arts, Business and Science. We designed H5P resources that integrate into individual courses to encourage interactivity (Singleton & Charlton, 2019) and provide feedback for self-assessment (Nicol & Mcfarlane-Dick, 2006). According to Nicol and Macfarlane-Dick’s seven principles of good feedback practice, good referencing practices were first explained, before students were given an opportunity to practice those skills. This was followed by detailed automated feedback. Student performance is recorded so that teachers can begin dialogues and use feedback to improve teaching.
The methodological approach taken aligns with Educational Design Research that aims to address real-life-learning issues through various cycles. Pre-interviews with teaching staff gave a better understanding of the expectations, support and students’ issues in referencing. Following these, students could access the tool and complete a questionnaire about their experiences. LMS and H5P analytics data added another dimension to quantitatively gauge engagement. Focus groups and interviews were conducted to ascertain the effectiveness and identify suggestions.
The qualitative data results in rich descriptions. The data was analysed in an open-coding approach (Saldana, 2013) for themes that emerged in response to the main questions asked. Student voices provided evidence of identified themes and were indicators of the overall results. Staff insights about the challenges aligned with preliminary results that tertiary students’ previous APA referencing experiences are variable. LMS analytics showed good engagement and students completed the module in about 27 minutes.
Feedback from the trial highlighted the benefits of interactivity and immediate feedback and led to amendments of the online resources. Participants commented, for example, “more practical activities”, and liked the final quiz for its instant feedback. As a result, additional activities were integrated. Some emerging themes from the trial were the relevance, consistency and practicality of the resources and indicated students’ willingness to use them for self-study. Feedback in Semester 1 confirmed those themes. From this round of feedback, the usefulness of the resources was highlighted. The evidence of effectiveness is summed up in that all participants would recommend the tool to peers.
As tool development continues, we will present up-to-date data. Further, we consider how these tools might support more faculties and institutions, extending this research to include a suite of referencing resources.
The Activity-Centred Analysis and Design framework – learning to connect theory, design and practice
Authors: Carvalho Lucila , Yeoman Pippa , Green Jenny 
Published: November 2022

The Activity-Centred Analysis and Design framework has been used to analyse and design a broad range of complex learning situations in universities, schools, museums, and informal settings. This workshop is an invitation to practically engage in innovative educational design, considering how an assemblage of elements – learning tasks, digital and material resources, and people – can be brought together to support productive learning activity. Participants will discuss the application of pedagogical concepts using a set of cards that were specifically created to prompt conversations about design for learning. Working in groups, participants will consider how their design choices align across scale levels, accommodate socio-cultural and socio-material approaches to learning, and support connection, collaboration and choice across diverse cohorts. The face-to-face half-day workshop will introduce participants to core ideas of the ACAD framework and wireframe, and a series of hands-on design challenges.
Cloning and identification of the CTLA-4IgV gene and functional application of vaccine in Xinjiang sheep
Authors: Kong Huifang , Zhao Shangqi , Zheng Jia , Liu Bin , Zhou Yanxia , Li Yanmin , Zhou Wentao , Zhou Xiaotao 
Published: November 2022

AbstractCytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is an important surface molecule of activated T cells that has a strong affinity with the B7 molecule on the surface of antigen-presenting cells. Among these molecules, the CTLA-4 extracellular region (CTLA-4 IgV) may be used as a novel immune adjuvant molecule for delivering antigens and inducing strong humoral and cellular immune responses. In this study, bioinformatics analysis was performed to determine and clone the extracellular region of Xinjiang sheep CTLA-4 (NM_001009214). The CTLA-4 IgV gene was amplified and ligated into the pMD19-T vector, and the positive bacteria were screened by blue-white spots for sequencing and comparison. The correctly sequenced CTLA-4 IgV was digested and then ligated into the prokaryotic expression vector pET-30a(+). The plasmid pET30a–CTLA-4 IgV was constructed to induce the expression of the recombinant protein CTLA-4 IgV. Thereafter, CTLA-4 IgV was identified. Clustal X multiple sequence alignment revealed that the protein sequence of Xinjiang sheep CTLA-4 IgV was different from that of the known CTLA-4 extracellular region. The 3D protein structure of Xinjiang sheep CTLA-4 IgV was constructed via the bioinformatics method. Subsequently, molecular docking between the Xinjiang sheep CTLA-4 IgV protein and the B7 molecule was conducted. Results revealed multiple binding sites in the extracellular region of Xinjiang sheep CTLA-4, and two multiple interactions ensured stable binding after docking. The functionality of the Xinjiang sheep CTLA-4 IgV protein was further verified by fusing the CTLA-4 extracellular V region with EgG1Y162, a protective protein fromEchinococcus granulosa, and the purified recombinant protein CTLA-4 IgV–EgG1Y162 was expressed with the mouse bone marrow-derived. The addition of the Xinjiang sheep CTLA-4 IgV protein at the amino terminus promoted the binding of EgG1Y162 to dendritic cells (DCs) and increased the maturation rate of these cells, further indicating that the protein could effectively improve the antigen presentation ability of DCs. The CTLA-4 extracellular domain protein of Xinjiang sheep is unique and has the potential to promote the presentation of the fusion protein by DCs as an adjuvant. The cloning and expression of this gene provide new measures and ideas for the preparation of the Xinjiang sheep vaccine to prevent zoonotic diseases.