bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pseudoaneurysm of the Peroneal Artery After Ankle Arthrodesis Treated by Endovascular Coil Embolization
Authors: Kasai Taro , Higashida Tomohiko , Hayashi Takaki , Yasui Tetsuro 
Published: August 2022

Case:
Pseudoaneurysms of the peroneal artery around the ankle joint have rarely been reported. We present the case of a 64-year-old man with a pseudoaneurysm of the anterior perforating branch of the peroneal artery associated with a screw inserted from the anterolateral distal tibia during ankle arthrodesis. Endovascular treatment with selective catheterization and coil embolization was successfully performed. The ankle joint achieved bone union without delay, and the pseudoaneurysm did not recur at the 18-month follow-up.

Conclusion:
This is the first report describing a pseudoaneurysm of the peroneal artery after ankle arthrodesis. Successful outcomes can be achieved by endovascular treatment.
Pediatric Septic Arthritis of the Knee due to Fusobacterium necrophorum in a Patient with Down Syndrome
Authors: Trutner Zoe , Hwang Richard , Bowen Richard 
Published: August 2022

Case:
A 16-year-old boy with a history of Down syndrome presented with right knee pain and swelling. He was diagnosed with isolated septic arthritis of the knee due to Fusobacterium necrophorum in the absence of current or recent oropharyngeal infection. He was successfully treated with arthroscopic irrigation and debridement and 12 weeks of oral antibiotics.

Conclusion:

Fusobacterium necrophorum is a part of the normal oral flora and a rare cause of septic arthritis, typically associated with recent oropharyngeal infection. However, patients with immune dysregulation such as those with Down syndrome may develop isolated septic arthritis due to transient hematogenous seeding.
Visualizing heterogeneous dipole fields by terahertz light coupling in individual nano-junctions used in transmon qubits
Authors: Wang Jigang , Kim Richard , Park J-M , Haeuser Samuel , Huang C , Cheng D , Koschny T , Oh Jin-Su , Zhou L , Kramer M , Luo L , Kopas Cameron , Cansizoglu H , Mutus J , Yadavalli K 
Published: August 2022

Abstract
The fundamental challenge underlying superconducting quantum computing is to characterize heterogeneity and disorder that lead to local electric field concentration, charge scattering, dissipation and ultimately decoherence. It is particularly challenging to probe deep sub-wavelength electric field distribution under electromagnetic wave coupling at individual nano-junctions and correlate them with structural imperfections from interface and boundary, ubiquitous in Josephson junctions used in transmon qubits. A major obstacle lies in the fact that conventional microscopy tools are incapable of measuring {\em simultaneous} at nanometer and terahertz, ``nano-THz” scales, which often associate with frequency-dependent charge scattering in nano-junctions. Here we directly visualize interface nano-dipole near-field distribution of individual Al/AlO$_{x}$/Al junctions used in transmon qubits. Our THz nanoscope images show a remarkable asymmetry across the junction in electromagnetic wave-junction coupling response that manifests as ``hot" vs ``cold" cusp spatial electrical field structures and correlates with defected boundaries from the multi-angle deposition processes in JJ fabrication inside qubit devices. The asymmetric nano-dipole electric field contrast also correlates with distinguishing, ``overshoot" frequency dependence that characterizes the charge scattering and dissipation at nanoscale, hidden in responses from topographic, structural imaging and spatially-averaged techniques. The scheme can be extended to guide qubit nano-fabrication for ultimately optimizing qubit coherence times.
Influence of waste brake oil on the rheological properties of coal sludge slurry
Authors: Xu Enle , Miao Zhenyong , Jiang Xiaofeng 
Published: August 2022

Abstract
In this work, the effect of waste brake oil (WBO) on the dispersion property of coal oil-sludge slurry (COSS) was investigated and comprehensively analyzed. Apparent viscosity of COSS decreases from 997mPa.s to 276mPa.s with the increasing of SS content from zero to 12% under the CV of 17.70 MJ/kg and O/S of 2.0. The combination of sewage sludge (SS) and WBO could decrease the apparent viscosity of COSS, and SS content and O/S are two important parameters to affect the apparent viscosity. WBO mainly contains the hydrocarbon compound and a lot of oxygenated functional groups according to its GC/MS results. WBO could cover on the surface of SS and coal particle, and reduce their hydrophobic character and the adsorbance amount of dispersant based on the FTIR, XPS and adsorption performance results. In addition, the mechanism of WBO on slurry characteristics of COSS was investigated. With the low content of WBO, the liquid bridges from WBO force the solid particles to adhere together and form a stable network structure, thus reducing the flow ability of the suspension. With the increasing of WBO, the network structures could be broken into cells by stirring it, resulting in a dramatic decrease in viscosity. This research provides a potential way to dispose the SS and waste industry oil.
Zinc Levels Assay in Children with Autism Spectrum Disorder by Quantum Magnetic Resonance Analyzer and Direct Colorimetry
Authors: Zayed Khalid Mahmoud El Sayed , Ibrahim Mostafa Azzaz , Farid Maisa Nasr , Shourbagy Omar El- Sayed Omar El- , Tarkan Reham Sabrey 
Published: August 2022

Abstract
Background: Autism is a long-term disability and a developmental disorder in which many studies suggested an association with serum low levels of zinc. In addition, the zinc to copper (Zn/Cu) ratio can be a biomarker of ASD as it is abnormally low in individuals with autism.Aim: The present study aimed to determine the levels of Zn in the bodies of children with autism spectrum disorder (ASD). The assay is done using new technology, the quantum magnetic resonance analysis (QMRA) method, and comparing its results with a reference testing laboratory method to determine the validity, sensitivity, and specificity of the new measurement method.Method: The study was performed in a group of children (M=19; F=11; age range=3-15 years) with ASD (n=30) and a control group of typically developing children (n=30) matched in terms of sex and age. The main variables in this study were the body values of Zn measured with a QMRA-998 8th Generation device and in patients’ sera by the reference direct colorimetric method.Statistical Analysis: Results were compared across groups using descriptive statistics, Pearson and Spearman’s correlation coefficients, Chi-Square significance, analysis of variance (ANOVA), and linear regression. In addition, a sensitivity and specificity cross-tabulation test was performed to evaluate the QMRA method in measuring Zn levels.Results: Both methods showed lower means for Zn levels in the ASD group than in the control group with a significant correlation between the two methods when measuring Zn levels. With the QMRA method, the sensitivity was 84% and specificity was 87%.Conclusion: It is suggested to test blood levels of Zn in all autistic children and give them a Zn supplement if needed. Non-invasive health measurement devices such as QMRA can be used as a screening or adjunct tool for the measurement of Zn levels in humans.
Health Related Quality Of Life (HRQOL) Among Patients With Childhood Acute Lymphoblastic Leukemia In Saudi Arabia: Cross- Sectional Study.
Authors: alqub aljohara , binsalleh raghad , alnaim lamya , alsultan abdulrahman , awwad sameh 
Published: August 2022

Abstract
BackgroundIncidences of Acute lymphoblastic leukemia (ALL) is the highest type among hematological malignancy affecting children. Cancer patients experience bothersome symptoms during chemotherapy courses, either from cancer itself or side effects from chemotherapy, which would be visible or invisible. In health care, where therapies aim to prolong survival, maintaining or improving HRQOL is becoming increasingly important.Methods This was a cross-sectional study. A total of 100 patients aged 2-12 years from King Saud University Medical City (KSUMC) and King Fahad Medical City (KFMC) are included to complete the parent proxy report of Pediatric Quality Of Life Inventory TM (PedsQLTM) 3.0 Cancer Module (Arabic version) which is a module to measure HRQOL in pediatrics.ResultsA total number of 100 patients participated in this study, their ages ranging from 2-12 years with a mean of 6. Male represented 59% of the sample and the other 41% were female. The overall HRQOL is divided into three levels, High (16%), intermediate (38%), poor (46%) represent the majority of the patients. The lowest scores of sub-scales that have affected HRQOL shown as mean were procedural anxiety (41.47), treatment anxiety (58.33) and worry (62.75) were the maximum mean value is 100. Procedural anxiety is affected by age, patients aged 6 or less have more procedural anxiety than older age. Patients who receive treatment for a year or less show an increase in worry. Male show more cognitive problems than females.Conclusions Results show that the majority of patients have poor HRQOL with a significant association between male gender and cognitive problems, younger age and procedural anxiety, short duration of treatment and worry.
Extension of Tablo TrEatmeNt Duration (XTEND) Study: Succesful 24 hour prolonged therapy with Tablo in critical patients
Authors: Zaman Tahir , Moore Kasadi , Jellerson Jennifer , Chahal Yaadveer , Schumacher Joshua , Silva Cynthia , Aragon Michael 
Published: August 2022

Abstract
BACKGROUND: The Tablo® Hemodialysis System (Tablo) is an all in one, easy-to-learn device featuring integrated water purification, on demand dialysate production and two-way wireless data transmission and is approved for use in the acute, chronic, and home settings. Prior reports have demonstrated Tablo’s ability to achieve clinical goals, seamlessly integrate into hospitals and reduce cost across a wide range of treatment times. Extension of the Tablo cartridge to 24 hours allows prolonged therapy and even greater flexibility for prescribers in the acute setting. The objective is to report on the first ever experience with Tablo prolonged therapy between 12 and 24 hours in critically ill patients treated at a single-center ICU. METHODS:Nursing staff were trained during a single training session on Tablo prolonged therapy. After a run-in period of five treatments, Tablo data were collected via real-time transmission to a cloud-based, HIPAA compliant platform and reviewed by site staff. Dialysis treatment delivery, clinically significant alarms, and clotting events were recorded. Sub-group analysis between COVID-19 positive and negative patients were reported. RESULTS:One hundred (100) consecutive Tablo prolonged treatments had a median prescribed treatment time of 24 hours and a median achieved treatment time of 21.3 hours. Median cartridge usage was 1.3 per treatment. The dialysis treatment time was delivered in 91% of treatments, with 6% ending early due to an alarm, and 3% ending due to clotting. Clinically significant alarms occurred at a median rate of 0.5 per treatment hour with a resolution time of 18 seconds. Median blood pump stoppage time related to these alarms was 2.3 minutes per treatment. Blood pump stoppage time was higher in the COVID-19 subgroup when compared to the non-COVID-19 subgroup. CONCLUSION:Tablo successfully achieves prescribed treatment time with minimal therapy interruptions from alarms or cartridge changes. This data demonstrates the effectiveness of Tablo in achieving personalization of treatments necessary for unstable patients and enabling successful delivery of extended therapy with minimal clotting. Tablo’s prolonged therapy meets the needs of critically patients, including COVID-19 positive patients, requiring renal replacement therapy for greater than 12 hours.
Meta Selective C–H Borylation Directed by Secondary Silicon Oxygen Interaction
Authors: Chattopadhyay Buddhadeb , Guria Saikat , Has Mirja Md , Dey Sayan 
Published: August 2022

Abstract
Remote meta selective C–H functionalization , , of aromatic compounds remains a challenging problem in chemical synthesis. Here, we report an iridium catalyst bearing a bidentate pyridine-pyridone (PY-PYRI) ligand framework that efficiently catalyzes this meta selective borylation reaction. We demonstrate that the developed concept can be employed to introduce a boron functionality at the remote meta position of phenols, phenol containing bioactive and drug molecules, which was an extraordinary challenge. Moreover, we have demonstrated that the method can also be applied for the remote C6 borylation of indole derivatives including tryptophan that was the key synthetic precursor for the total synthesis of Verruculogen and Fumitremorgin A alkaloids. The origin of the remote meta selectivity was described as a secondary silicon oxygen interaction that was never used in C–H functionalization chemistry.
TMEM201 overexpression is associated with tumor progression and unfavorable prognosis in hepatocellular carcinoma
Authors: Wang Xiaolei , Fang Jun , Wang An , Zhu Wuhui 
Published: August 2022

Abstract

Background More and more evidences suggest there was a relationship between nuclear envelope and tumor development, but the functional contributions of TMEM201 remain largely unidentified. Objective This study aimed to explore the TMEM201 mRNA expression and its potential biologic functions in hepatocellular carcinoma (HCC) patients. Methods Expression array and clinical data were collected from the Cancer Genome Atlas (TCGA) database. TMEM201 expression data and its clinical information in HCC were confirmed by Chi-square test and Student’s t test. We used Kaplan–Meier analysis, Cox regression and nomogram to evaluate the prognostic capability of TMEM201. Gene set enrichment analysis (GSEA) was applied to find significant biological pathways associated with TMEM201. Results In contrast to normal tissues, TMEM201 was remarkably upregulated in HCC (P < 0.05). High-expressing TMEM201 was significantly related to advanced TNM stage, poor histologic grade, high Ishak score, worse Child–Pugh grade, vascular invasion, positive alpha fetoprotein (AFP) (P < 0.05). Kaplan–Meier analysis revealed that high TMEM201 expression was associated with poor overall survival (OS) and disease-free interval (DFI). In addition, multivariate analysis confirmed that high-expressing TMEM201 was an independent predicter of unfavorable OS and DFI (P < 0.05). On the basis of TMEM201 and TNM stage, the nomograms had a good predictive performance. Furthermore, TMEM201 DNA copy gain and miR-500a-3p upregulation were related to high TMEM201 mRNA expression in TCGA-LIHC. GSEA analysis demonstrated that “cell cycle” pathway, “DNA replication” pathway, “spliceosome” pathway and “homologous recombination” pathway were significantly enriched. Conclusion Above mentioned results indicate that TMEM201 has potential as a novel therapeutic target in HCC, and it is a good predictor associated with progression and prognostics of HCC.
Maximum Tumor Absorbed Dose Measured by Voxel-Based Multicompartmental Dosimetry as a Response Predictor in Yttrium-90 Radiation Segmentectomy for Hepatocellular Carcioma
Authors: Rincón Javier Orcajo , Regi Amanda Rotger , Peña Ana Matilla , Berenguer Laura Reguera , Leyte Manuel González , Martín Laura Carrión , Santa Jaime Atance García De La , Boyra Miguel Echenagusia , Ruiz Cristina González , Rodriguez Arturo Colón , Farto Juan Carlos Alonso 
Published: August 2022

Abstract
Objective
Advances in hepatic radioembolization are based on a selective approach with radical intent and the use of multi-compartment dosimetric analysis. The objective of this study is to assess the utility of voxel-based dosimetry in the quantification of actual absorbed doses in radiation segmentectomy procedures and to establish cut-off values predictive of response.
Methods
Ambispective study in hepatocarcinoma patients treated with radiation segmentectomy. Calculated dosimetric parameters were mean tumor absorbed dose, maximum tumor AD, tumor AD in 30, 50 and 70% of tumor volume and mean AD in non-tumor liver. Actual absorbed dose (aAD) was calculated on the Y-90-PET/CT image using 3D voxel-based dosimetry software. To assess radiological response, localized mRECIST criteria were used. Objective response rate (ORR) was defined as CR or PR.
Results
24 HCC patients, BCLC 0 (5), A (17) and B (2) were included. Mean yttrium-90 administered activity was 1.38GBq in a mean angiosome volume of 206.9cc and tumor volume 56.01cc. Mean theoretical AD was 306.3Gy and aAD 352Gy. A very low concordance was observed between both parameters (rho_c 0.027). ORR at 3 and 6m was 84.21% and 92.31% respectively. Statistically significant relationship was observed between maximum tumor absorbed dose and complete radiological response at 3m (p 0.022).
Conclusion
A segmental approach with radical intention leads to response rates greater than 90%, being the tumor maximum absorbed dose the dosimetric parameter that best predicts radiological response in voxel-based dosimetry.
Development and implementation of new online strategies that increase physical activity behavior in cancer patients
Authors: Barrio Soraya Casla , Herrero Lucía Gil , Montealegre Monica Castellanos , Santamaría Marina Pollan , Torre Julio De la 
Published: August 2022

Abstract
Purpose
The purpose of this study was to evaluate effectiveness of different online exercise strategies to increase physical activity levels in cancer patients implemented during the lockdown that may be maintained as usual care after it.
Methods
Three different strategies were designed and implemented during the lockdown, adapting the exercise oncology service in two ways: based on restrictions of the pandemic situation and the evolution of pandemic information.
Results
After exercises interventions, cancer patients reported a significant rise of 92% in physical activity levels and a reduction of 52.9% in sitting time. In terms on the weight, there were no significant changes.
Conclusions
Online programs were an effective strategy to increase physical activity levels in cancer patients during the lockdown, particularly when the partial lockdown was in effect. A higher level of control and longer intervention were more effective in increasing physical activity levels in cancer patients during and after the lockdown.
TINYCD: A (Not So) Deep Learning Model For Change Detection
Authors: Codegoni Andrea , Lombardi Gabriele , Ferrari Alessandro 
Published: August 2022

Abstract

The aim of change detection (CD) is to detect changes occurred in the same area by comparing two images of that place taken at different times. The challenging part of the CD is to keep track of the changes the user wants to highlight, such as new buildings, and to ignore changes due to external factors such as environmental, lighting condition, fog or seasonal changes. Recent developments in the field of deep learning enabled researchers to achieve outstanding performance in this area. In particular, different mechanisms of space-time attention allowed to exploit the spatial features that are extracted from the models and to correlate them also in a temporal way by exploiting both the available images. The downside is that the models have become increasingly complex and large, often unfeasible for edge applications. These are limitations when the models must be applied to the industrial field or in applications requiring real-time performances. In this work we propose a novel model, called TinyCD, demonstrating to be both lightweight and effective, able to achieve performances comparable or even superior to the current state of the art with 13-150X fewer parameters. In our approach we have exploited the importance of low-level features to compare images. We introduce a novel mixing block capable of cross correlating features in both space and time domains. Finally, to fully exploit the information contained in the computed features, we define the PW-MLP block able to perform a pixel wise classification.
Advanced Directives’ Knowledge in Palliative Care: Do the Sociodemographic Features Influence it? A Survey in a Portuguese Population.
Authors: Martins Catarina Sampaio , Nunes Rui 
Published: August 2022

Abstract
BackgroundAdvance care planning (ACP) allows the definition of goals and preferences for future health care, improving communication between patients and caregivers. Portuguese Advance Directives (PAD) ensure a living will and/or the assignment of a health care proxy (HCP). Knowledge on PAD and HCP is low, and the influence of demographic factors is still not clear. We intend to identify sociodemographic features associated with knowledge on PAD and HCP, and the registration of PAD.MethodsPatients in palliative care and their caregivers were included, and sociodemographic data was acquired. Participants were asked about their previous knowledge of PAD, the role of an HCP, and about previously writing a PAD.ResultsA total of 60 patients and their caregivers were included, with differences regarding age (p < .001), gender (p = .003), education (p < .001), job (p < .001), marital status (p = .043), and access to the internet (p = .003), but not regarding religion (p = .21). 13.3% were aware of PAD, 15.0% were aware of HCP, and 5.0% previously filled a PAD. Non-Catholic participants were significantly more aware of these three topics.ConclusionsOur results are partially different from other Portuguese reports, probably due to differences in the populations, but consistent with results from other countries. Reports on the influence of religion in ACP are conflicting, with similarities in religious values between patients and HCP influencing end-of-life decisions. Improving education is necessary, namely in palliative care. There is low awareness of PAD and HCP in palliative care, and there is higher knowledge on these topics among non-Catholic individuals.Trial registration: ClinicalTrials.gov ID NCT05090072. Retrospectively registered on 22/10/2021.https://clinicaltrials.gov/ct2/show/NCT05090072?term=NCT05090072&cond=Advance+Directives&draw=2&rank=1