bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preeclampsia correlates with maternal and perinatal outcomes in Regional Public Hospital, Madiun, Indonesia
Authors: Putri Ariyan Fadhila Anindya , Sukowati Eko Gunawan , Fatmawati Widi 
Published: April 2022

HIGHLIGHTS
1. Preeclampsia, the high blood pressure during pregnancy, and its complications has significant role in maternal outcomes.2. Correlation between preeclampsia and maternal as well as perinatal outcomes was examined.3. Preeclampsia correlated significantly with delivery process, IUGR, LBW, and preterm birth, but not significantly with antepartum and postpartum hemorrhages, eclampsia, HELLP syndrome, maternal and perinatal mortality, as well as with neonatal asphyxia.

ABSTRACT
Objectives: This research aimed to find correlation between preeclampsia and maternal as well as perinatal outcomes in Regional Public Hospital, Madiun, Indonesia, from 1 January 2017 to 30 September 2020.
Materials and Methods: An observational analysis was applied in this study with a cross-sectional design. This study used secondary data from medical records of Regional Public Hospital, Madiun, Indonesia, with retrospective sampling and total sampling methods. Samples were 250 preeclamptic mothers with or without severe symptoms.
Results: Of 250 preeclamptic mothers, only 216 samples could participate in this study. Maternal outcomes included spontaneous PV delivery (12.22%), SC (87.78%), antepartum hemorrhage (0.45%), postpartum hemorrhage (6.33%), eclampsia (0.45%), HELLP syndrome (0.90%), and maternal mortality (0.45%), while perinatal outcomes covered IUGR (7.69%), LBW (33.94%), preterm birth (12.67%), perinatal mortality (2.71%), and asphyxia neonatorum (13.12%).
Conclusion: There was a significant correlation between preeclampsia with or without severe symptoms and maternal outcomes, which was the delivery process, and perinatal outcomes, which were the IUGR, LBW, and preterm birth. However, there was no significant correlation for antepartum hemorrhage, postpartum hemorrhage, eclampsia, HELLP syndrome, maternal mortality (maternal outcomes), perinatal mortality and neonatal asphyxia (perinatal outcomes).
Potential of trichloroacetic acid (TCA) for cervical precancerous lesions treatment in Indonesia
Authors: Winata I Gde Sastra , Taufiq Musa 
Published: April 2022

HIGHLIGHTS
1. One of the most prevalent disease in females worldwide is cervical cancer.2. Simple and safe modality with high efficacy to treat cervical precancerous lesions before being progressed to cancer is necessary. 3. Trichloroacetic acid (TCA) has those advantages, so it will become an effective treatment for cervical precancerous lesions in the future.

ABSTRACT
Cervical cancer becomes one of the most prevalent disease in female worldwide. Human papillomavirus (HPV) is main etiology of cervical cancer, thus this disease is preventable. Before progressed into invasive cervical cancer, cervical precancerous lesions developed and classified into 3 stages: CIN1 (LSIL), CIN2, and CIN3 (CIN2+ also referred as HSIL). World Health Organization (WHO) arranged ‘screen-and-treat’ programme to treat cervical precancerous lesions immediately before it progressed to cancer. However, a simple and safe modality with high efficacy is necessary to accommodate this strategy. Trichloroacetic acid (TCA) has those advantages and some research suggested high efficacy to treat cervical precancerous lesions with simple, safe, and cost-effective. TCA has potential to become effective treatment for cervical precancerous lesions in the future.
Analisis Pengaruh Hambatan Samping (Studi Kasus: Jalan Raya Za Pagar Alam di Bawah Flyover Kedaton Kota Bandar Lampung)
Authors: Bertarina  , Mahendra Oka , Lestari Fera , Safitri Destiana 
Published: April 2022

Kebutuhan masyarakat akan transportasi pada saat ini berkembang pesat dan daya beli masyarakat juga cukup tinggi, yang menimbulkan ketidakseimbangan antara pertumbuhan jumlah kendaraan dengan pertumbuhan prasarana jalan raya. Hal ini mengakibatkan kepadatan lalulintas pada ruas Jalan ZA Pagar Alam di bawah Flyover Kedaton kota Bandar Lampung. Padahal ruas jalan tersebut merupakan salah satu jalan arteri yang ada di kota Bandar Lampung, yang seharusnya tidak terpengaruh oleh hambatan samping. Tujuan dari penelitian ini yaitu untuk mengetahui kinerja arus lalulintas di Jalan ZA Pagar Alam, tingkat kepadatan arus lalulintas di Jalan ZA Pagar Alam serta mengetahui pengaruh hambatan samping pada saat jam sibuk. Pelaksanaan penelitian ini dilakukan dengan tiga tahapan: 1) Survei pendahuluan, 2) Survei volume lalulintas, 3) Survei hambatan samping. Berdasarkan hasil perhitungan dan uji analisis yang sudah dilakukan menunjukan bahwa jenis hambatan samping faktor kendaraan keluar masuk sangat berpengaruh signifikan terhadap kecepatan arus lalulintas dengan hasil pada jalan Z.A Pagar Alam adalah 1,6915. Hal ini menunjukan bahwa melebihi batas toleransi yang ditetapkan oleh Panduan Kapasitas Jalan Indonesia 2014 yaitu sebesar 0,75 yang menunjukan ruas jalan tersebut merupakan daerah macet yang disebabkan oleh adanya gangguan dari samping jalan dan ditambah dengan arus lalulintas yang padat.
Use of Accelerating Rate Calorimeter in Reservoir Oil Selection for Air Injection Process
Authors: Zelenko V. , Solignac F. 
Published: April 2022

Abstract
The paper proposes an interpretation of the phenomena observed on several ARC (Accelerating Rate Calorimeter) tests performed with different crude oils. The ARC apparatus was used as a closed system and the gas formed at the end of the reactions were analyzed by chromatography. Low Temperature Oxidation (LTO) and Negative Temperature Coefficient (NTC) areas were identified during these tests. The proposed interpretation is based on an analogy with the reaction mechanisms occurring during light saturated hydrocarbon oxidation. The determination of kinetics parameters for oxidation reactions was investigated. In the meantime, limitations of the ARC device, when used as a closed system, clearly appeared. The conclusion is that not only the determination of basic kinetics parameters is generally not possible with ARC tests, but also that a serious selection of oil reservoir for air injection technique based on these tests seems questionable.

Introduction
Success of oil recovery by air injection greatly depends on knowledge of reaction mechanism between oxygen and oil in porous media. Oil oxidation during in-situ combustion involves numerous competing reactions occurring through different temperature ranges. Generally, in order to simplify the studies, investigators classify the reactions in three steps (Dubdub1 et al; Brigham2 et al).
- First, the low temperature oxidation (L TO) reactions, which are heterogeneous (gas/liquid) and generally produce polar compounds. For some light oils, if the reservoir conditions are convenient, L TO can produce mainly carbon oxides and water at long time (Solignac3).
- Then comes the medium temperature oxidation (MTO) : oxidation reactions are slow, therefore cracking/pyrolysis which leads to coke, becomes the main phenomenon.
- Finally, high temperature oxidation (HTO) : oxygen reacts with unoxidized oil, polar compounds and coke (Belgrave4 et al; Solignac3) to give carbon oxides and water.
This paper describes ARC experiments on crude oil oxidation and proposes an analysis of experimental data, using works (Ben-Ai'm5 et al; Le Chatelier6 et al; Newitt7 et al; Cathonnet8 et al) on light saturated hydrocarbons (CICIO). We compare heat rate behaviors measured by the calorimeter (Fig. 1) with zones of reactivity (cool and normal flames) occurring during oxidation of light saturated hydrocarbons in the gas phase.
Build a Bioinformatic Analysis Platform and Apply it to Routine Analysis of Microbial Genomics and Comparative Genomics
Authors: Liu Hualin , Xin Bingyue , Zheng Jinshui , Zhong Hao , Yu Yun , Peng Donghai , Sun Ming 
Published: April 2022

Abstract
More and more frequently, genomics and comparative genomics have been used as routine methods for general microbiological research. However, using several tools or even writing some scripts are required for completing a simple analysis, which is complicated for most biological researchers. To simplify the operation process, particularly for the convenience of microbiologists, here we have developed PGCGAP, a comprehensive, malleable, and easily installed prokaryotic genomic and comparative genomic analysis pipeline. PGCGAP implements genome assembly, gene prediction and annotation, genome and metagenome distance estimation, phylogenetic analysis, COG annotation, pan-genome analysis, inference of orthologous gene groups, variant calling and annotation, and screening for antimicrobial and virulence genes. Although we have tried our best to simplify the installation and usage of PGCGAP, it may be difficult for non-bioinformaticians to master it. Therefore, a protocol was created to help microbiologists without any experience in bioinformatics to establish their bioinformatics platform and perform routine analyses. This protocol shows how to choose the equipment to install a Linux subsystem on a laptop with a Windows 10 system, to install the PGCGAP and perform all analyses with an example dataset (This protocol applies to PGCGAP version 1.0.34 and later). The protocol requires a basic understanding of Linux, so an additional web page was written to help uninitiated users learn Linux and whole-genome sequencing (https://github.com/liaochenlanruo/pgcgap/wiki/Learning-bioinformatics or http://bcam.hzau.edu.cn/linuxwgs.php).
Automated, quantitative Fast FLIM-FRET (qF3):A step-by-step protocol to measure dissociation constants for protein-protein interactions in live-cell screening applications
Authors: Osterlund Elizabeth J. , Hirmiz Nehad , Pemberton James M. , Fang Qiyin , Andrews David W. 
Published: April 2022

Abstract
Fluorescence lifetime imaging microscopy (FLIM) can detect Fӧrster resonance energy transfer (FRET) to measure protein-protein interactions in live cells. Traditional FLIM-FRET uses relative intensities to represent protein expression, consequently limiting users to a qualitative comparison of resulting binding curves. In our quantitative Fast FLIM-FRET (qF3) method we use fluorescent protein standards to convert intensity to concentration and then fit binding curves to determine live-cell apparent dissociation constants (Kd). To acquire measurements with high spatial and temporal resolution in live cells we built a multiplexed system for rapid data acquisition. In this way, complete quantitative binding curves can be generated for hundreds of high-resolution regions of interest from 384 samples in less than 24 hours. In addition, we introduce new automated criteria for quality control in screening. We applied this method to screen a large set of BH3 mimetic drugs targeting BCL-2 family protein dimeric interactions in live cells (associated publication in Science Advances). Here we provide a step-by-step protocol for the qF3 method, which can be adapted for use with other proteins of interest on a multitude of other FLIM-FRET platforms, enabling future automated analysis of protein-protein interactions in live cells at even faster speeds.
Phytochemical Analysis and Antibacterial Activity of selected Kenyan Wild Orchids
Authors: Chagona Polycarp , Kwamboka Nancy , Gaya Humphrey , Makonde Huxley , Adem Aggrey , Osano Kenneth , Kawaka Fanuel 
Published: April 2022

Abstract
The current study evaluated antibacterial activity of dichloromethane and methanol (DCM-MeOH) extracts of four Kenyan orchid species against three selected bacterial strains. Extracts of E1 (Ansellia africana), E2 (Trydactylescottelli), E3 (Polystachyabella) and E4 (Liparis bowkeri) were screened for antibacterial activity againstStaphylococcus aureus, Bacillus subtilis and Pseudomonas aeruginosausing agar disc diffusion. Ampicillin was included as a positive control.Qualitative analysis revealed the presence of flavonoids, saponins, alkaloids, tannins, terpenoids, steroids and glycosides. Trydactyle scottelli and Polystachyabella extracts revealed stronger presence of tannins and steroids respectively compared to the others. All extracts showed varying levels of antibacterial activity against the test bacteria. However, extracts of Polystachyabella and Liparis bowkeri against Bacillus subtilis and Ansellia africana against Pseudomonas aeruginosa exhibited higher activities similar to that of Ampicillin. The study further showedthat the DCM-MeOH extracts of the four orchids contain potential bioactive compounds that should be further analysed for conventional and traditional management of bacterial infections.
Pickering Emulsions Co-Stabilised by Cellulose Nanofibres and Nicotinamide Mononucleotide
Authors: Yu Dehai , Luo Qi , Wang Qiang , Wang Huili , Song Zhaoping , Li Shan , Liu Wenxia 
Published: April 2022

Abstract
Emulsified solid particles adsorbed at the oil–water interface can stabilise Pickering emulsions by acting as a physical barrier to the coalescence of oil droplets. Cellulose nanofibres (CNFs) have been used in food-grade Pickering emulsions because of their excellent performance as a low cost and sustainable material. Nicotinamide mononucleotide (NMN) is a small-molecule zwitterion with polar functionality capable of interacting with the CNFs. The ability of cationic CNFs and NMN to co-stabilise sunflower oil Pickering emulsions was investigated under various conditions using methods such as contact angle measurement, creaming stability, rheology, microscopy, thermal stability, and water-holding capacity. Emulsions with ultra-high stability, good gelation, and high plasticity were obtained using single-step shear dispersion with 0.25 wt% CNFs, 0.05–0.3 wt% NMN, and near-neutral pH. NMN stabilised the oil–water interface through electrostatic interactions and hydrogen bonding with CNFs. NMN transferred into the aqueous phase and interacted with CNFs to form a complex with a three-dimensional network structure, which improved the bulk viscosity and steric hindrance of the emulsion and created more compact adsorption of CNFs at the oil–water interfaces. Overall, the synergistic effects of various factors allow NMN to effectively co-stabilise Pickering emulsions with CNFs, making it an exciting method that can be used to encapsulate oil-soluble substances.
Predicting ADHD from early childhood data using data mining
Authors: Nurisa Mohsen , Dastghaibyfard Gholamhossein , Hadianfard Habib 
Published: April 2022

Abstract
One of the most common disorders among school-age children is attention deficit hyperactivity disorder (ADHD). Although the symptoms mostly appear between the ages of five and seven, some can be traced back to early childhood. Objective: In this study, we identified and ranked early childhood characteristics that can correctly predict ADHD diagnosis at the age of seven based on none-clinical data, and then used those features in a computer model to enhance the prediction accuracy. Method: The data used in this study was from the Millennium Cohort Study, which contains comprehensive information about the biological, genetic, and environmental characteristics of children and their parents. In our analysis, we conducted a complete mining process, including feature selection (regression and Support Vector Machine) and modeling (Artificial Neural Network) to select and use proper characteristics to predict ADHD diagnosis, and finally, evaluation (10-fold cross-validation) to assess the accuracy of the prediction. Results: The proposed mining process selected and categorized 28 features (out of 3908) as the most important predictors, some[may] have not been reported by other studies before. These features belong to different age groups and both children and their parents. Total difficulty score of SDQ, child’s weight, total health, and parent’s income were among the features with the most predictive power. The results from the final model show an F1-score of 82.85%, which, compared to previous studies, shows a significant improvement.
Critical soil thickness analysis and stability prediction of slope
Authors: He Yuqiong , Wang Yinsheng , Xu Zemin , Sun Rong 
Published: April 2022

Abstract
In order to realize the prediction on the slope stability,the slope in Dingjiafen in Chuxiong, Yunnan, China was selected as the worksite to be studied,the critical soil thickness (Dcr) when the landslide was started under saturated condition of slope and the maximum soil thickness（Dmax）when the landslide was started under unsaturated condition of slope were inferred by using the slope stability physical model. Based on digital elevation model (DEM), the critical soil thickness and maximum soil thickness of each slope unit at the start of landslide were calculated,the criterion of slope instability was determined, and the influence of rainfall infiltration process, soil thickness, the physical and mechanical properties of soil, slope surface and the bedrock surface topography on slope stability was analyzed.The analysis results were verified by means of modeling and numerical simulation calculation of FLAC3D. The research results shows that the critical soil thickness and the maximum soil thickness of the slope unite with different topographies at the start of landslide are not the same. Besides, the slope units with the critical soil thickness between 1m~3m were located at the right and left side of the Chu-Meng highway, which conformed with the actual position of sliding. Simulating the thickness of soil layer when slope units were at the critical state of landslide by using this method can predict the stability of slopes.
Patient Safety Culture Impacts on Hospital Performance: a Systematical Review Of The Literature
Authors: Zhang Na , Xie ChunGuang , Talib Lilis Surienty Abd 
Published: April 2022

Abstract
The purpose of this paper is to explore which dimensions impact hospital performance in previous researches. Chinese public hospitals reform was to attach importance to the public welfare of hospitals, since the positions of hospitals are the place to heal the dead, heal the wounded, and save patients. World Health Organization (WHO) defines patient safety as “reducing the unnecessary injury related to health care to an acceptable minimum risk control process.” Based on a systematic review of the literature, the article found that limited researches on patient safety culture on hospital performance under China environment. This study suggests that future Chinese researchers can explore the relationship between patient safety culture and hospital performance.
How social support has impacted the health behaviours of people living with and beyond cancer during the COVID-19 pandemic: A qualitative study
Authors: Miller Natalie , Conway Rana , Pini Simon , Buck Caroline , Gil Natalie , Lally Phillippa , Beeken Rebecca J , Fisher Abigail 
Published: April 2022

Abstract
PurposeSocial support facilitated healthy behaviours in people living with and beyond cancer (LWBC) before the COVID-19 pandemic. Little is known about how social support impacted their health behaviours during the pandemic when social restrictions were imposed. The aim of this study was to qualitatively explore how social support impacted the health behaviours of people LWBC during the COVID-19 pandemic.MethodsSemi-structured interviews were conducted via telephone with 24 adults living with and beyond breast, prostate and colorectal cancer. Inductive and deductive framework analysis was used to analyse the data. ResultsSix themes developed. These were 1) Companionship and accountability as motivators for physical activity, 2) Familial social influence increasing alcohol consumption, 3) Importance of friends, communities and government in maintenance of food security, 4) Partner support in food practices, 5) Informational support as important for behaviour change, and 6) Validation of health behaviours from immediate social networks. ConclusionThis study found that companionship, social influence, instrumental support, informational support and validation impacted the health behaviours of people LWBC during the COVID-19 pandemic. Interventions for people LWBC could recommend co-participation in exercise with friends and family; promote the formation of collaborative implementation intentions with family to reduce alcohol consumption; and encourage supportive communication between partners about health behaviours. These interventions would be useful during pandemics and at other times. Government policies to help support clinically extremely vulnerable groups of people LWBC during pandemics should focus on providing access to healthier foods.
Economic Evaluations of Radioembolization With Itrium-90 Microspheres in Hepatocellular Carcinoma: a Systematic Review
Authors: Alonso JC , Casans I , González FM , Fuster D , Rodríguez A , Sánchez N , Oyagüez I , Burgos R , Williams AO , Espinoza N 
Published: April 2022

Abstract
Background: Transarterial radioembolization (TARE) with yttrium-90 microspheres is a clinically effective therapy for hepatocellular carcinoma (HCC) treatment. This study aimed to perform a systematic review of the available economic evaluations of TARE for the treatment of HCC.Methods: The Preferred Reported Items for Systematic reviews and Meta-Analyses guidelines was followed by applying a search strategy across six databases. All studies identified as economic evaluations with TARE for HCC treatment in English or Spanish language were considered. Conversions were performed using 2020 purchasing-power-parity ($US PPP).Results: Among 423 records screened, 20 studies (6 cost-analyses, 3 budget-impact-analyses, 2 cost-effectiveness-analyses, 8 cost-utility-analyses, and 1 cost-minimization analysis) were finally included (13 European, 6 USA and 1 Canadian). The assessed populations included early- (n=4), and intermediate-advanced-stages patients (n=15). Included studies were evaluated from a payer perspective (n=20) and included both payer and social perspective (n=2). TARE was compared with transarterial chemoembolization (TACE) (n=9) or sorafenib (n=11). Life-years gained for TARE ranged from 1.3 to 3.1 vs. TACE and from 1.1 to 2.53 for TARE vs. sorafenib. TARE was associated with lower treatment cost in ten studies. TARE cost varied widely according to Barcelona Clinic Liver Cancer (BCLC) staging system and ranged from 1,311 PPP/month (BCLC-A) to 71,890 PPP/horizon time 5 years (BCLC-C). The incremental cost-utility ratio for TARE vs TACE resulted in a $PPP 17,397/Quality-adjusted-Life-Years (QALY) (n=1) and for TARE vs. sorafenib ranged from dominant (more effectiveness and lower cost) to 3,363 PPP/QALY.Conclusions: Economic evaluations of TARE for HCC treatment are heterogeneous. Overall, TARE is a cost-effective short- and long-term therapy for the treatment of intermediate-advanced HCC.