bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intra-articular Treatment with Triamcinolone Hexacetonide Associated with Gold Nanoparticles Reduces Cartilage Degeneration in an Animal Model of Osteoarthritis
Authors: Silveira Paulo Cesar Lock , dos Santos Haupenthal Daniela Pacheco , Resmini Marcus Barg , Da Silva Leandro Almeida , Colares Mateus Cardoso , de Roch Casagrande Laura , Milanez Venturini Ligia , de Andrade Thiago Antônio Moretti , do Bomfim Fernando Russo Costa , Thirupathi Anand , Emilio Feuser Paulo , Dal Pizzol Felipe 
Published: December 2022

Introduction:The association between triamcinolone hexacetonide (TH) and gold nano-particles (GNPs) represents a promising treatment due to the potential anti-inflammatory and anti-oxidant effects of these compounds. In this study, we evaluated the effects of intra-articular treat-ment of TH associated with GNPs in a mechanical model of osteoarthritis (OA).Methods:Fifty Wistar rats were divided into five groups: Sham; OA; OA+TH; OA+GNPs; OA+TH-GNPs. Both applications were performed 30 and 60 days after the model was induced. Af-ter 30 days of the last application, the animals were euthanized.Results:Only the combined treatment with TH and GNPs promoted a reduction in pro-inflammatory cytokines and an increase in anti-inflammatory cytokines. The OA+TH-GNPs group obtained a significant reduction in the production of oxidants and oxidative damage markers while an increase in antioxidants. Histologically, all treated groups showed results of a significant increase in cartilage thickness and chondrocyte count, the OA+TH-GNPs group had similar behavior to the group without osteoarthritis, with significantly smaller amounts of chondrocytes than the OA group.Conclusion:The intra-articular use of TH associated with GNPs may be able to prevent the pro-gression of the pathology and minimize joint degradation.
A Review on Recent Development of Novel Heterocycles as Acetylcholinesterase
Inhibitor for the Treatment of Alzheimer’s Disease
Authors: Patel Ashish , Shah Drashti , Patel Yug , Patel Stuti , Mehta Meshwa , Bambharoliya Tushar 
Published: December 2022

Abstract:
Alzheimer's Disease (AD), affecting a large population worldwide, is characterized by the old population's loss of memory and learning ability. Cholinergic deficiency is associated with AD, and various cholinesterase inhibitors have been developed to treat AD, including naturally-derived inhibitors, synthetic analogs, and hybrids. Acetylcholinesterase (AChE) has obtained a re-newed interest as a therapeutic target in Alzheimer's disease (AD) due to increased neural cells' function by increasing the concentration of acetylcholine. In this review, we reported the recent de-velopment of novel heterocyclic compounds such as coumarin-benzotriazole hybrids, carbazole de-rivatives, tacrine conjugates, N-benzyl-piperidine-aryl-acyl hydrazones hybrid, spiropyrazoline de-rivatives, coumarin-dithiocarbamate hybrids, etc., as AChE inhibitors for the treatment of Alz-heimer disease. All the bioactive compounds show an effect on different cells and interact simulta-neously with the catalytic active site (CAS) and peripheral anionic site (PAS) of AChE with a nar-row range of IC50 values from 0.4 nm to 88.21 μm using Ellman’s in vitro AChE assay method and show high BBB permeability in vitro. In addition, the in vitro fluorescence assay study using Am-plex Red assay kits revealed that all the compounds could inhibit self-induced β-amyloid (Aβ) ag-gregation with the highest inhibition range from 31.4 to 82%. Furthermore, most of the compounds show a low toxicity profile during in vivo studies. The results suggest that all the compounds consti-tute promising leads for the AChE targeted approach for Alzheimer’s disease.
A Review on Herbal Drugs Used in the Treatment of Peptic Ulcer
Authors: Roy Anup Jyoti , Maut Chinmoy , Gogoi Hemanta Kumar , Ahmed Syed Isfaqul , Kashyap Ankita 
Published: December 2022

Background:An ulcer is a condition characterized by inflammation, irritation, or erosion in the mucosal lining of the stomach or duodenum. Hence, peptic ulcer is the ulcer of both the stomach and the duodenum. 10% of the world’s population is affected by chronic peptic ulcers. The formation of peptic ulcers depends on gastric juice pH and the decrease in mucosal defenses. Nonsteroidal antiinflammatory drugs (NSAIDs) and Helicobacter pylori (H. pylori) infection are the two significant factors disrupting mucosal resistance to injury. Indian herbal plants are exceptional for their ethnic, ethnobotanical, and ethno-pharmaceutical use. In this review, attempts have been made to gain information regarding some plants that may be used to treat or prevent peptic ulcers. The ultimate goal of peptic ulcer disease treatment is to reduce pain, cure ulcers, and prevent recurrence.Objective:The aim of the study was to gain knowledge about several common medicinal plants employed in Ayurveda or contemporary science for the treatment or prevention of peptic ulcers and some natural and simple approaches to cure ulcers using readily available herbs.Methods:The literature search was carried out using search engines, like Google Scholar, Scopus, PubMed, Medline, Springer, etc.Results:The extensive literature search showed natural herbs to have potential anti-ulcer activity, including cabbage, bananas, liquorice, fenugreek, garlic, Terminalia chebula, Acacia arabica, Aegle marmelos, Aloe vera, Allium sativum, Plantago ispagula, Mimosa pudica, Annona squamosa, Azadirachta indica, and Galega purpurea.Conclusion:This study concluded several medicinal plants to effectively prevent or cure peptic ulcers caused by a variety of factors, including H. pylori, aspirin, indomethacin, alcohol, and others.
Focal Lipogranuloma Inflammation: A Case Report of the Lung Origin
Authors: Ding Xing , Zhang Jing , Chen Fen , Zhou Changning , Chen Yang , Chen Kuntao 
Published: December 2022

Introduction:
Limited experience exists regarding the clinical features of focal lipogranuloma
inflammation of the lung, and there are no supporting guidelines for the diagnostic approach.

Case Description:
We present the case of a 20-year-old man who was found to have a pulmonary nodule
with a smooth margin during a health examination. He underwent wedge resection of the left lower
lung to achieve a tissue diagnosis; this showed focal lipogranuloma inflammation of the lung.

Conclusion:
In this report, we combined imaging and pathological findings to reach the diagnosis,
with a view to assisting clinicians in navigating this challenging clinical situation.
Evaluation of Gold Nanoparticles on the Expression of NorA and NorB
Efflux Pumps in Ciprofloxacin-resistant Staphylococcus aureus Isolated
from Burn Patients
Authors: Zolfaghari Mohammad Reza , Soleimani Mohammad Hossein , Shakib Pegah , Javadi Ali 
Published: December 2022

Background:
In the development of multidrug resistance, efflux pumps effectively pump
drug compounds out of cells, which results in reduced membrane permeability to drug compounds.
This study evaluated the effect of gold nanoparticles on the inhibition of norA and norB efflux pumps
in ciprofloxacin-resistant Staphylococcus aureus isolated from burn patients in Qom province, Iran.

Methods:
In this cross-sectional study, S. aureus strains were isolated from burn patients in Qom hospital,
Iran. After gold nanoparticles were synthesized using chemical reduction and characterized by
spectrophotometry, transmission electron microscopy (TEM), and dynamic light scattering (DLS),
ciprofloxacin resistance of S. aureus was screened by the disc diffusion method. The Minimum Inhibitory
Concentration (MIC) of ciprofloxacin (CCCP), ciprofloxacin + gold nanoparticles (CCCP + gold
nanoparticles), and ciprofloxacin + CCCP was determined. Moreover, norA and norB genes were
evaluated by PCR using special primers. Real-time PCR was then performed for norA and norB genes.

Results:
Of 88 S. aureus strains tested, 50 (56.81%) were resistant to ciprofloxacin. From the 50
ciprofloxacin-resistant S. aureus strains, 12 isolates had active pumps. Real-time PCR of 12 ciprofloxacin-
resistant S. aureus and S. aureus ATCC 25923 before and after exposure to ciprofloxacin, gold
nanoparticles, and gold nanoparticles with sub-MIC ciprofloxacin revealed significant differences in
expression of norA and norB genes before exposure to the treatments compared to after exposure (p
<0.05).

Conclusion:
Gold nanoparticles with ciprofloxacin could be used to prevent the expression of pump
genes involved in resistance to fluoroquinolone compounds.
Alkaloids Extract from Linum usitatissimum Attenuates 12-OTetradecanoylphorbol- 13-Acetate (TPA)-induced Inflammation and Oxidative Stress in Mouse Skin
Authors: Merakeb Mohamed Sofiane , Bribi Noureddine , Ferhat Riad , Aziez Meriem , Yanat Betitera 
Published: December 2022

Background:In traditional medicine, Linum usitatissimum treats inflammatory, gastrointestinal, and cardiovascular diseases.Objectives:The present study aims to assess the anti-inflammatory and anti-oxidant effects of total alkaloid extract from Linum usitatissimum seeds (ALU) on the ear histological integrity and oxidant- antioxidant status in a mice model of a sub-chronic inflammation induced by multiapplication of TPA.Methods:Topical TPA treatment induced various inflammatory changes, including edema formation, epidermal thickness, and the excess production of reactive oxygen species. Tissue samples were used for the measurement of reduced glutathione (GSH) and nitric oxide (NO) levels and Myeloperoxidase (MPO) and Catalase (CAT) activities.Results:Oral administration of ALU (50, 100, and 200 mg/kg) produced anti-inflammatory and anti-oxidant effects. Also, ALU significantly reduced ear edema and inflammatory cell infiltration and restored the integrity of the ear.Conclusion:These findings suggest that the total alkaloid extract from Linum usitatissimum seeds presents significant anti-inflammatory and anti-oxidant effects on TPA-induced sub-chronic inflammation model in NMRI mice and can be used as an anti-inflammatory and anti-oxidant agent for the therapeutic management of inflammatory disorders.
Remote teaching and school refusal behavior – lessons learned from the COVID-19 pandemic
Authors: Hansen Ulla Irene , Larsen Kenneth , Sundberg Hanne , Munkhaugen Ellen Kathrine 
Published: December 2022

Abstract
When the Norwegian government closed down schools and kindergartens in response to the increased spread of COVID-19, the use of homeschooling raised concerns about students with school refusal behavior and the school system’s ability to address their special needs in these circumstances. Six students referred to the school absenteeism team were interviewed about their circumstances, using an author-developed interview. The results indicate that the students rated homeschooling as very satisfactory. Students with school refusal behavior participated in homeschooling and their attendance continued during the initial reopening of schools.
KurdFace Morph Dataset Creation Using OpenCV
Authors: Hussein Arezu Rezgar , Rashid Rasber Dhahir 
Published: December 2022

Automated facial recognition is rapidly being used to reliably identify the identities of individuals for a variety of applications, from automated border control to unlocking mobile phones. The attack of Morphing has presented a significant risk to the face recognition system (FRS) at automated border control. Face morphing is a technique for blending the facial images of two or more people such that the outcome looks like both of them. For example, a morphing attack may be used to get a fake passport by using a morphed image. This passport can be used by both the modified image contributors while crossing the border. Due to the publicly available digital altering tools that criminals may use to carry out face morphing attacks. Morph Attack Detection (MAD) systems have received a lot of attention in recent years. In the absence of automated morphing detection, Face Recognition Systems (FRS) are extremely susceptible to morphing attacks. Due to the limited number of publicly available face morph datasets to investigate, especially to our knowledge, there is no Kurdish morph dataset. In this work, we decided to generate a new face dataset, including morphed images which we named as "KurdFace" dataset. OpenCV was used to generate morphed images. Then we study the susceptibility of biometric systems to such morphed face attacks by designing and creating a Morph Attack Detection model to distinguish morphed images from genuine ones. To evaluate the robustness of our dataset regarding morphing attack detection, we compare it with the AMSL dataset to determine the classification error rate on both datasets to see how our dataset is different from others. Local Binary Pattern and Uniform Local Binary Pattern are used as feature extraction techniques, and as a classifier, SVM is utilized. The experimental result shows that our dataset is suitable for research purposes.
Karaburun Yarımadası’nın Geç Miyosen Stratigrafisi, Yeni Memeli Bulguları ve Bölgesel Korelasyon, Batı Anadolu
Authors: GÖKTAŞ Fikret , KAYA Tümel Tanju , TARHAN Erhan , MAYDA Serdar 
Published: December 2022

Foça Çöküntüsü’nün batı kenarındaki Mordoğan alt havzasında tanımlanan Eşendere grubu, alüviyal Saip, palustrin Boyabağ ve gölsel Çukurcak kireçtaşı formasyonlarından oluşmaktadır. Eşendere grubu, Orta Miyosen yaşlı Hisarcık formasyonunun gölsel çökelleri üzerinde uyumsuzlukla yer alır. Alüvyon yelpazesi çökellerinden oluşan Saip formasyonu, Geç Miyosen tortullaşmasının başlangıcını yansıtır. Palustrin çamur düzlüğü istifiyle temsil edilen ve ilk kez bu çalışmada tanımlanan Boyabağ formasyonu, Saip formasyonu ile gölsel Çukurcak kireçtaşı arasında yer alır. Gölsel Çukurcak kireçtaşı, Eşendere grubunun son birimidir.
Boyabağ formasyonunun çamurtaşı egemen istifi içinde bulunan Hipparion aff. giganteum ve Hippopotamodon major Kıyı Ege bölgesinde MN10 biyozonuna işaret eden ilk bulgulardır. Bu büyük memeli bulgularına dayanılarak, Foça Çöküntüsü’ndeki Geç Miyosen tortullaşmasının ~10 milyon yıl önce başladığı ileri sürülebilir.
Boyabağ formasyonunun çamurtaşı egemen istifi içinde bulunan Hipparion aff. giganteum ve Hippopotamodon major Kıyı Ege bölgesinde MN10 biyozonuna işaret eden ilk bulgulardır. Bu büyük memeli bulgularına dayanılarak, Foça Çöküntüsü’ndeki Geç Miyosen tortullaşmasının ~10 milyon yıl önce başladığı ileri sürülebilir.
Two Servants, One Master: The Common Acoustic Origins of the Divergent Communicative Media of Music and Speech
Authors: Bannan Nicholas 
Published: December 2022

Abstract
This article explores and examines research in the field of human vocalization, proposing an evolutionary sequence for human acoustic perception and productive response. This involves updating and extending Charles Darwin’s 1871 proposal that musical communi­cation predated language, while providing the anatomical and behavioral foundations for the articulacy on which it depends. In presenting evidence on which a new consensus regarding the emergence of human vocal ability may be based, we present and review contributions from a wide range of disciplines, illustrating that the phenomenon of human musicality may have had more of a core function in shaping our anatomy and culture than has hitherto been recognized. Essential to the adaptive sequence on which this depends is human perceptual and productive response to the properties of the Harmonic Series. Both music and language have emerged from the auditory and performative consequences of this relationship.
Strategi Pemerintah Desa Dalam Pemberdayaan Petani Alami Di Desa Kaloling Kabupaten Bantaeng
Authors: Hasdiki Hasdiki , Hamrun Hamrun 
Published: December 2022

Tujuan penelitian ini untuk mengetahui bentuk strategi pemerintah desa dalam upaya melakukan pemberdayaan petani alami di desa kaloling, metode penelitian ini adalah metode kualitatif yakni memberikan gambaran secara objektif terkait bagaimana keadaan sebenarnya objek yang diteliti dan tipe penelitian yang digunakan adalah tipe fenomenologi. Data yang digunakan adalah sumber data primer dan sumber data sekunder dengan jumlah informan sebanyak 7 orang. Dan dokumentasi. Teknik Analisis data dan digunakan dalam penelitian ini yaitu Reduksi data, Penyajian data, dan Penarikan kesimpulan. Pengabsahan data yang digunakan adalah Triangulasi sumber, Triangulasi tekik dan Triangulasi waktu. Penelitian ini bertujuan mengetahui strategi Formulasi strategi, Implementasi strategi, dan Evaluasi strategi dalam Pemberdayaan Petani Alami di Desa Kaloling Kabupaten Bantaeng. Hasil penelitian menunjukkan bahwa Strategi Pemerintah Desa Dalam Pemberdayaan Petani Alami di Desa Kaloling Kabupaten Bantaeng telah selesai dengan pendekatan kekeluargaan dan keorganisasian guna mencapai tujuan dari penelitian ini yaitu menciptakan kesejahteraan masyarakat dalam bertani tampa menggunakan bahan kimia. Faktor yang memperlambat strategi ini dikarenakan beberapa masyarakat tani masih menginginkan bercocok tanam dengan sesuatu hal yang serba singkat dan cepat tampa memikirkan dampak yang akan mereka dapatkan nantinya. Tetapi masalah tersebut sudah di atasi oleh pihak SPA dan dapat di terima secara berlahan oleh beberapa petani desa kaloling.
Changes in muscular wall of artificial bladder in experiment
Authors: Savchuk R. V. , Kostyev F. I. , Golovko S. V. , Kolosov O. M. , Zadorognuk A. I. 
Published: December 2022

Objective. To estimate morphometric changes of the artificial bladder muscular wall, which was formatted of terminal ileum, in experiment in early and late postoperative periods.
Materials and methods. The investigation was conducted in the chronic experiment conditions on 22 mini-pigs, ageing from 16 to 19 mo. After performance of cystectomy to the animals the artificial bladder was formatted, using terminal ileum. In 3, 6 and 12 mo after the artificial bladder formation the animals were removed from the experiment.
Results. Studying of thickness of longitudinal and circular muscular layers of artificial bladder in mini-pigs in 2 mo have shown its statistically meaningful enhancement, comparing with control value in 2,14 - (643.7 ± 53.1) mcm and 3.36 - (1358.11 ± 86.60) mcm times, accordingly, and the common muscular layer thickness have enhanced in 2.84 times – (2001.81 ± 143.40) mcm, caused by its hypertrophy. In 6 mo more intense processes of muscular wall hypertrophy were seen in artificial bladder of experimental animals: the longitudinal muscular layer thickness have had statistically significantly enhanced in 3.61 times, while of a circular one – in 5.42 times, and of a common - in 4.65 times. In 12 mo after ileocystoplasty in muscular wall of artificial bladder a statistically significant enhancement of longitudinal layer thickness was noted, comparing with according index of intact animals in 5.52 times, while a circular one – in 5.58, and a common – in 5.13 times.
Conclusion. The main processes of the artificial bladder muscular wall hypertrophy occur during first 6 mo after its formation, especially intensively in period from 3 to 6 mo. In consequent six-month period a statistically significant enhancement of the longitudinal muscle layer thickness of artificial bladder in 0.91 times was noted, comparing with according index in previous 6 mo and the indices of the longitudinal and circular muscle layers thickness, which did not differ statistically with according results of experimental investigations in previous 6 mo. The urine reservoir, formatted of the ileum part, was not accustomed for performance of new functions, because in its wall evolution and transformation occurs in a version of hypertrophy in longitudinal and circular layers as a result of the intestinal tube denervation and the urine impact.
Constrained K-means and Genetic Algorithm-based Approaches for Optimal Placement of Wireless Structural Health Monitoring Sensors
Authors: Hung Shih-Lin , Kao Ching-Yun , Huang Jyun-Wei 
Published: December 2022

Optimal placement of wireless structural health monitoring (SHM) sensors has to consider modal identification accuracy and power efficiency. In this study, two-tier wireless sensor network (WSN)-based SHM systems with clusters of sensors are investigated to overcome this difficulty. Each cluster contains a number of sensor nodes and a cluster head (CH). The lower tier is composed of sensors communicating with their associated CHs, and the upper tier is composed of the network of CHs. The first step is the optimal placement of sensors in the lower tier via the effective independence method by considering the modal identification accuracy. The second step is the optimal placement of CHs in the upper tier by considering power efficiency. The sensors in the lower tier are partitioned into clusters before determining the optimal locations of CHs in the upper tier. Two approaches, a constrained K-means clustering approach and a genetic algorithm (GA)-based clustering approach, are proposed in this study to cluster sensors in the lower tier by considering two constraints: (1) the maximum data transmission distance of each sensor; (2) the maximum number of sensors in each cluster. Given that each CH can only manage a limited number of sensors, these constraints should be considered in practice to avoid overload of CHs. The CHs in the upper tier are located at the centers of the clusters determined after clustering sensors in the lower tier. The two proposed approaches aim to construct a balanced size of clusters by minimizing the number of clusters (or CHs) and the total sum of the squared distance between each sensor and its associated CH under the two constraints. Accordingly, the energy consumption in each cluster is decreased and balanced, and the network lifetime is extended. A numerical example is studied to demonstrate the feasibility of using the two proposed clustering approaches for sensor clustering in WSN-based SHM systems. In this example, the performances of the two proposed clustering approaches and the K-means clustering method are also compared. The two proposed clustering approaches outperform the K-means clustering method in terms of constructing balanced size of clusters for a small number of clusters. Doi: 10.28991/CEJ-2022-08-12-01 Full Text: PDF