bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fast Near‐Infrared Photodetection Using III–V Colloidal Quantum Dots
Authors: Sun Bin , Najarian Amin Morteza , Sagar Laxmi Kishore , Biondi Margherita , Choi Min‐Jae , Li Xiyan , Levina Larissa , Baek Se‐Woong , Zheng Chao , Lee Seungjin , Kirmani Ahmad R. , Sabatini Randy , Abed Jehad , Liu Mengxia , Vafaie Maral , Li Peicheng , Richter Lee J. , Voznyy Oleksandr , Chekini Mahshid , Lu Zheng‐Hong , García de Arquer F. Pelayo , Sargent Edward H. 
Published: June 2022

AbstractColloidal quantum dots (CQDs) are promising materials for infrared (IR) light detection due to their tunable bandgap and their solution processing; however, to date, the time response of CQD IR photodiodes is inferior to that provided by Si and InGaAs. It is reasoned that the high permittivity of II–VI CQDs leads to slow charge extraction due to screening and capacitance, whereas III–Vs—if their surface chemistry can be mastered—offer a low permittivity and thus increase potential for high‐speed operation. In initial studies, it is found that the covalent character in indium arsenide (InAs) leads to imbalanced charge transport, the result of unpassivated surfaces, and uncontrolled heavy doping. Surface management using amphoteric ligand coordination is reported, and it is found that the approach addresses simultaneously the In and As surface dangling bonds. The new InAs CQD solids combine high mobility (0.04 cm2 V−1 s−1) with a 4× reduction in permittivity compared to PbS CQDs. The resulting photodiodes achieve a response time faster than 2 ns—the fastest photodiode among previously reported CQD photodiodes—combined with an external quantum efficiency (EQE) of 30% at 940 nm.
A Self‐Regulated Electrostatic Shielding Layer toward Dendrite‐Free Zn Batteries
Authors: Hu Zhengqiang , Zhang Fengling , Zhao Yi , Wang Huirong , Huang Yongxin , Wu Feng , Chen Renjie , Li Li 
Published: June 2022

AbstractAlthough aqueous Zn batteries have become a more sustainable alternative to lithium‐ion batteries owing to their intrinsic security, their practical applications are limited by dendrite formation and hydrogen reactions. The first application of a rare earth metal type addition to Zn batteries, cerium chloride (CeCl3), as an effective, low‐cost, and green electrolyte additive that facilitates the formation of a dynamic electrostatic shielding layer around the Zn protuberance to induce uniform Zn deposition is presented. After introducing CeCl3 additives, the electrochemical characterizations, in situ optical microscopy observation, in situ differential electrochemical mass spectrometry, along with density functional theory calculations, and finite element method simulations reveal resisted Zn dendritic growth and enhanced electrolyte stability. As a result, the Zn–Zn cells using the CeCl3 additive exhibit a long cycling stability of 2600 h at 2 mA cm−2, an impressive cumulative areal capacity of 3.6 Ah cm−2 at 40 mA cm−2, and a high Coulombic efficiency of ≈99.7%. The fact that the Zn–LiFePO4 cells with proposed electrolyte retain capacity significantly better than the additive‐free case is even more exciting.
Manipulating Hierarchical Orientation of Wet‐Spun Hybrid Fibers via Rheological Engineering for Zn‐Ion Fiber Batteries
Authors: Xia Zhou , Li Shuo , Wu Guiqing , Shao Yanyan , Yang Dongzi , Luo Jinrong , Jiao Zhenyang , Sun Jingyu , Shao Yuanlong 
Published: June 2022

AbstractWet‐spinning is a promising strategy to fabricate fiber electrodes for real commercial fiber battery applications, according to its great compatibility with large‐scale fiber production. However, engineering the rheological properties of the electrochemical active materials to accommodate the viscoelasticity or liquid crystalline requirements for continuous wet‐spinning remains a daunting challenge. Here, with entropy‐driven volume‐exclusion effects, the rheological behavior of vanadium pentoxide (V2O5) nanowire dispersions is regulated through introducing 2D graphene oxide (GO) flakes in an optimal ratio. By optimizing the viscoelasticity and liquid‐crystalline behavior of the spinning dope, the wet‐spun hybrid fibers display controlled hierarchical orientation. The wet‐spun V2O5/rGO hybrid fiber with the optimal 10:1 mass fraction (V2O5/rGO10:1) exhibits a highly oriented nanoblock arrangement, enabling efficient Zn‐ion migration and an excellent Zn‐ion storage capacity of 486.03 mAh g−1 at 0.1 A g−1. A half‐meter long quasi‐solid‐state fiber Zn‐ion battery is assembled with a polyacrylamide gel electrolyte and biocompatible Ecoflex encapsulation. The thus‐derived fiber Zn‐ion battery is integrated into a wearable self‐powered system, incorporating a highly efficient GaAs solar cell, which delivers a record‐high overall efficiency (9.80%) for flexible solar charging systems.
2D Metal–Organic Framework Cu3(HHTT)2 Films for Broadband Photodetectors from Ultraviolet to Mid‐Infrared
Authors: Liu Chun‐Ki , Piradi Venkatesh , Song Jiajun , Wang Ziru , Wong Lok‐Wing , Tan Eng‐Hao‐Louis , Zhao Jiong , Zhu Xunjin , Yan Feng 
Published: June 2022

AbstractCu3(HHTT)2 (HHTT: 2,3,7,8,12,13‐hexahydroxytetraazanaphthotetraphene) is a novel 2D conjugated metal–organic framework (2D c‐MOF) with efficient in‐plane d–π conjugations and strong interlayer π–π interactions while the growth of Cu3(HHTT)2 thin films has never been reported until now. Here, the successful fabrication of highly oriented wafer‐scale Cu3(HHTT)2 thin films with a layer‐by‐layer growth method on various substrates is presented. Its semiconducting behavior and carrier transport mechanisms are clarified through temperature and frequency‐dependent conductivity measurements. Flexible photodetectors based on Cu3(HHTT)2 thin films exhibit reliable photoresponses at room temperature in a wavelength region from UV to mid‐IR, which is much broader than those of solution‐processed broadband photodetectors reported previously. Moreover, the photodetectors can show a typical synaptic behavior and excellent data recognition accuracy in artificial neural networks. This work opens a window for the exploration of high‐performance and multifunctional optoelectronic devices based on 2D c‐MOFs.
W Single‐Atom Catalyst for CH4 Photooxidation in Water Vapor
Authors: Wang Ye , Zhang Jiangwei , Shi Wen‐Xiong , Zhuang Gui‐Lin , Zhao Qiu‐Ping , Ren Jing , Zhang Peng , Yin Hua‐Qing , Lu Tong‐Bu , Zhang Zhi‐Ming 
Published: June 2022

AbstractSolar‐driven high‐efficiency and direct conversion of methane into high‐value‐added liquid oxygenates against overoxidation remains a great challenge. Herein, facile and mass fabrication of low‐cost tungsten single‐atom photocatalysts is achieved by directly calcining urea and sodium tungstate under atmosphere (W‐SA‐PCN‐m, urea amount m = 7.5, 15, 30, and 150 g). The single‐atom photocatalysts can manage H2O2 in situ generation and decomposition into ·OH, thus achieving highly efficient CH4 photooxidation in water vapor under mild conditions. Systematic investigations demonstrate that integration of multifunctions of methane activation, H2O2 generation, and decomposition into one photocatalyst can dramatically promote methane conversion to C1 oxygenates with a yield as high as 4956 µmol gcat−1, superior to that of the most reported non‐precious photocatalysts. Liquid–solid phase transition can induce the products to facilely switch in from HCOOH to CH3OH by pulling the catalyst above water with CH3OH/HCOOH ratio from 10% (in H2O) to 80% (above H2O).
Waterproof and Breathable Graphene‐Based Electronic Fabric for Wearable Sensors
Authors: Wang Shuying , Huang Haizhou , Liu Cheng , Xia Yuyan , Ye Changqing , Luo Zewei , Cai Chunhua , Wang Chaolun , Lyu Liangjian , Bi Hengchang , Wu Xing , Sun Litao 
Published: June 2022

AbstractElectronic skin (E‐skin) is widely used in bionic prosthesis, soft robotics, and wearable electronic devices. Waterproof and breathable membranes that provide a high level of protection and comfort are promising core materials for meeting the pressing demand for E‐skin. However, creating such materials exhibiting waterproofness, breathability, and ease of fabrication has proven to be a great challenge. In this paper, waterproof, breathable Modal‐based knitted fabric E‐skin is proposed by using a simple, low‐cost three‐step process including the graphene oxide (GO) loading, GO‐reducing, and polydimethylsiloxane loading. The prepared E‐skin is insensitive to common liquids in daily life including water, tea, milk, and coffee, showing superior waterproof capability. The breathability is also tested with a water vapor transmission rate of ≈13.6 mg cm−2 h−1. Besides, this E‐skin can achieve reliable human motion monitoring. The authors believe this E‐skin can provide a reliable principle for further design and development of waterproof and breathable electronic skin.
Conjugate Addition of α‐Substituted Acyl Imidazoles to Nitroalkenes Catalyzed by Nickel Bisoxazoline and B(C6F5)3
Authors: Yin Qingyu , Li Zhiming , Wu Fan , Ji Mingtong , Fu Chao , Wu Xiaoyu 
Published: June 2022

AbstractA diastereoselective and enantioselective conjugate addition of α‐substituted acyl imidazole to nitroalkene catalyzed by nickel bisoxazoline complex and B(C6F5)3 has been developed. This reaction tolerated a wide range of acyl imidazoles and nitroalkenes, affording a series of conjugate adducts in yields ranging from 38% to 99% with 4:1 to 99:1 dr and 13% to 98% ee. The use of strong Lewis acid B(C6F5)3 as co‐catalyst proved vital to the success of this process. The potential scalability and utility of the current protocol are demonstrated by a reaction on a 3 mmol scale and further transformations of the product.magnified image
Eliciting an Immunostimulatory Tumor Microenvironment to Enhance the Antitumor Efficacy by Targeted Cancer Immunotherapy
Authors: Zhang Ya‐Xuan , Zhang Jun‐Jie , Wang Wei , Guo Xiao‐Ying , Hou Li‐Shuang , Zhang Tang‐Rui , Wang Bao‐Long , Kou Fang , Huan Meng‐Lei , He Wei , Zhou Si‐Yuan , Zhang Bang‐Le 
Published: June 2022

AbstractTumor‐associated macrophages (TAMs) in tumor microenvironment represent an ideal therapeutic target for cancer immunotherapy. A targeted cancer immunotherapy strategy through reprogramming M2 macrophages to reverse the immunosuppressive microenvironment is proposed and the antitumor effects via targeted immunostimulatory therapy are evaluated. The developed M2‐macrophage‐targeted nanoparticles (M2‐TNPs) can specially target and reprogram the M2 macrophages via polarization to the antitumor M1 phenotype. Compared with nontargeted nanoparticles, M2‐TNPs loading zoledronic acid can specifically be recognized by M2 macrophages but not other macrophages and mounted productive antitumor responses, showing enhanced antitumor efficacy by targeted immunostimulation in vitro and in vivo. Moreover, when combining the chemotherapeutic drug dacarbazine with M2‐TNPs for treatment of melanoma, a dramatic synergistic effect in cancer therapy through eliciting an immunostimulatory tumor microenvironment to restore the antitumor immunity is demonstrated. These studies provide preclinical evidence that targeted TAM‐reprogramming treatment strategies can hold tremendous promise in cancer immunotherapy.
Sustainable Pb Management in Perovskite Solar Cells toward Eco‐Friendly Development
Authors: Luo Huaiqing , Li Pengwei , Ma Junjie , Han Liyuan , Zhang Yiqiang , Song Yanlin 
Published: June 2022

AbstractPb‐based perovskite solar cells (PSCs) as one of the most promising photovoltaic technologies for commercialization have attracted tremendous attention in recent years. However, the toxicity and leakage of heavy metal Pb from perovskite film have become critical obstacles for eco‐friendly development. Extreme weather conditions such as heavy rain, high temperature, or strong sunlight may accelerate the undesired decomposition of perovskite film and cause inevitable Pb contamination in the ecosystem, which results in a potential threat to animals and the environment. In this review, guidelines for successfully managing Pb in PSCs are provided to open a pathway toward sustainable development. First, the toxicological research of Pb that can cause health problems for humans and contaminate the environment is discussed. Then, the decomposition mechanism of perovskite film and Pb leakage pathways under simulated environments in terms of moisture, high temperature, and illumination are briefly reviewed. Moreover, strategies to inhibit Pb leakage including physical sequestration, chemical adsorption, and Pb component substitution engineering are systematically summarized. Finally, different pathways for achieving the goal of Pb recycling and sustainable utilization are systematically analyzed. With a comprehensive understanding of these effects, rational strategies for sustainable Pb management can be made to accelerate the development of this emerging field.
“A sorely neglected field”: A multisite study of self‐reported humanities exposure among emergency medicine residents
Authors: Balhara Kamna S. , Irvin Nathan , Zink Korie L. , Mohan Sanjay , Olson Adriana S. , Tackett Sean ,   Emergency Medicine Education Research Alliance (EMERA), Regan Linda 
Published: June 2022

AbstractBackgroundThe Association of American Medical Colleges has identified the humanities as fundamental to medical education across all specialties. Evidence from undergraduate medical education (UME) demonstrates the humanities' positive impacts on outcomes that could be relevant to patient care and trainee well‐being in emergency medicine (EM) residency training. However, less is known about the humanities' role in graduate medical education (GME).ObjectivesThe objectives were to describe EM residents' self‐reported exposure to the humanities and its relationship with their empathy, tolerance of ambiguity, and patient‐centeredness, and to assess their attitudes toward the humanities in GME.MethodsThis cross‐sectional survey‐based study was conducted at six U.S. EM residency programs in 2018–2019. Quantitative analyses included linear regressions testing for trends between humanities exposures and outcomes, adjusted for sex, year in training, and clustering within programs; adjunct analysis of free‐text responses was performed using an exploratory constructivist approach to identify themes about views on the humanities' role in medicine.ResultsResponse rate was 54.8% (153/279). A total of 65% of respondents were male and 28.1% of respondents had a preceding humanities degree. Preceding humanities degree and current self‐reported humanities exposure were positively associated with performance on empathy subscales (p = 0.02). Seventy‐five percent (n = 114) of respondents agreed humanities are important in GME; free‐text responses revealed perceived positive impacts of humanities on generating well‐rounded clinicians and enhancing patient care.ConclusionsEngagement with the humanities may be associated with empathy among EM residents. Although the magnitude of associations was smaller than that seen in UME, this study demonstrates resident interest in humanities and suggests that extracurricular engagement with the humanities may be insufficient to prolong positive impacts seen in UME. Further research is needed to explore how to sustain these benefits through integration or addition of the humanities in existing GME curricula.
Resident attitudes, experiences, and preferences on initiating buprenorphine in the emergency department: A national survey
Authors: Yu Megan J. , Hawk Kathryn 
Published: June 2022

AbstractObjectivesThe objective was to describe emergency medicine (EM) resident attitudes, preferences, and experiences around the knowledge and skills around the evidence‐based treatment of opioid use disorder (OUD) in the emergency department (ED).MethodsWe created an online survey that was distributed by the Emergency Medicine Residents’ Association research committee listserv to approximately 6600 resident physicians at all levels of EM residency training. Data were collected between June 2020 and October 2020. This 12‐question voluntary, anonymous survey included questions exploring EM resident preferences and experiences around the education and exposure to the evidence‐based management of patients with OUD in the ED setting. Descriptive statistics were used.ResultsA total of 288 of 6600 invited EM residents (response rate 4.4%) from 127 different EM residency programs across 38 states in the United States, District of Columbia, and Puerto Rico completed the survey. Most respondents (165/288; 57.3%) reported that it was “very important” for emergency physicians to have training to initiate buprenorphine treatment for patients with OUD. Just under half (140/288; 48.6%) reported they have or will receive X‐waiver training during residency and 46.9% (135/288) reported experience prescribing buprenorphine in the ED. The estimated proportions of EM faculty at responding residents’ primary teaching hospital with an X‐waiver was “most or all” (48/285; 16.8%), “about half” (23/285; 8.1%), “a handful” (79/285; 27.7%), “one or two” (33/285; 11.6%), “none” (19/285; 6.7%), or “not sure” (83/285; 29.1%).ConclusionSurvey results suggest that resident emergency physicians perceive the evidence‐based management of OUD to be relevant to EM residency training and are interested in receiving training on initiating medications for OUD treatment in the ED. Opportunities to improve resident education and clinical use of buprenorphine during ED residency training were identified.
Highly efficient monovalent ion transport enabled by ionic crosslinking‐induced nanochannels
Authors: Zhang Yiren , Lin Yuqing , Ying Jiadi , Zhang Wei , Jin Yan , Matsuyama Hideto , Yu Jianguo 
Published: June 2022

AbstractCharge‐governed ion transport is of significant importance to industrial development, and advanced membrane materials with fast and selective ionic transport are essential components. In cell membranes, ionic transport is mainly determined by the charge‐governed protein channels, representing an architecture with functional differentiation. Inspired by this, a novel class of membranes was developed by ionically crosslinking sulfonated (poly[ether ether ketone]) and quaternized poly(2,6‐dimethyl‐1,4‐phenylene oxide) to construct the cationic conductive biomimetic nanochannels. Ionic crosslinking was tailored to realize nanophase separation and efficient ion transport mainly based on surface chemistry without altering the scaffold feature of polymeric pore channels. The best‐performing ionic crosslinking membrane exhibited a high ionic permeation (2.23 mol·m−2·h−1 for K+) and high cationic selectivity (7.91 for K+/Mg2+), which were comparable with the commercial monovalent cation permselective CIMS membrane, owing to the negligent surface resistance toward monovalent cations but strong positively charged repulsion against divalent cations.
Network‐based meta‐analysis and the candidate gene association studies reveal novel ethnicity‐specific variants in MFSD3 and MRPL43 associated with dementia with Lewy bodies
Authors: Shigemizu Daichi , Asanomi Yuya , Akiyama Shintaro , Higaki Sayuri , Sakurai Takashi , Ito Kengo , Niida Shumpei , Ozaki Kouichi 
Published: June 2022

AbstractDementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia in elderly people, following Alzheimer's disease. Only three genes, SNCA (α‐synuclein), APOE (apolipoprotein E), and GBA (glucosylceramidase), have been convincingly demonstrated to be associated with DLB. Here, we applied whole‐genome sequencing to blood samples from 61 DLB patients and 45 cognitively normal controls. We used accumulation of candidate mutations to detect novel DLB‐associated genes. Subsequent single nucleotide polymorphism (SNP) genotyping and association studies in a large number of samples from Japanese individuals revealed novel heterozygous variants in MFSD3 (rs143475431, c.888T>A:p.C296*; n = 5,421, p = 0.00063) and MRPL43 (chr10:102746730, c.241A>C:p.N81H; n = 4,782, p = 0.0029). We further found that the MFSD3 variant increased plasma levels of butyrylcholinesterase (n = 1,206, p = 0.029). We believe that our findings will contribute to the understanding of DLB and provide insight into its pathogenic mechanism for future studies.
Synergistic Catalysis between a Dipeptide Phosphonium Salt and a Metal‐Based Lewis Acid for Asymmetric Synthesis ofN‐Bridged [3.2.1] Ring Systems
Authors: Chen Yuan , He Jiajia , Zhuang Cheng , Liu Zanjiao , Xiao Kai , Su Zhishan , Ren Xiaoyu , Wang Tianli 
Published: June 2022

AbstractWe present an unprecedented synergic catalytic route for the asymmetric construction of fluorinatedN‐bridged [3.2.1] cyclic members of tropane family via a bifunctional phosphonium salt/silver co‐catalyzed cyclization process. A broad variety of substrates bearing an assortment of functional groups are compatible with this method, providing targeted compounds bearing seven‐membered ring and four contiguous stereocenters in high yields with excellent stereoselectivities. The gram‐scale preparations, facile elaborations and preliminary biological activities of the products demonstrate the application potential. Moreover, both experimental and computational mechanistic studies revealed that the cyclization proceeded via a “sandwich” reaction model with multiple weak‐bond cooperative activations. Insights gained from our studies are expected to advance general efforts towards the catalytic synthesis of challenging chiral heterocyclic molecules.
A Nanobody‐on‐Quantum Dot Displacement Assay for Rapid and Sensitive Quantification of the Epidermal Growth Factor Receptor (EGFR)
Authors: Su Ruifang , Wu Yu‐Tang , Doulkeridou Sofia , Qiu Xue , Sørensen Thomas Just , Susumu Kimihiro , Medintz Igor L. , van Bergen en Henegouwen Paul M. P. , Hildebrandt Niko 
Published: June 2022

AbstractBiosensing approaches that combine small, engineered antibodies (nanobodies) with nanoparticles are often complicated. Here, we show that nanobodies with different C‐terminal tags can be efficiently attached to a range of the most widely used biocompatible semiconductor quantum dots (QDs). Direct implementation into simplified assay formats was demonstrated by designing a rapid and wash‐free mix‐and‐measure immunoassay for the epidermal growth factor receptor (EGFR). Terbium complex (Tb)‐labeled hexahistidine‐tagged nanobodies were specifically displaced from QD surfaces via EGFR‐nanobody binding, leading to an EGFR concentration‐dependent decrease of the Tb‐to‐QD Förster resonance energy transfer (FRET) signal. The detection limit of 80±20 pM (16±4 ng mL−1) was 3‐fold lower than the clinical cut‐off concentration for soluble EGFR and up to 10‐fold lower compared to conventional sandwich FRET assays that required a pair of different nanobodies.