bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute chest syndrome in pediatric sickle cell disease
Authors: Yousef Abdullah A. , Shash Hwazen A. , Almajid Ali N. , Binammar Ammar A. , Almusabeh Hamza Ali , Alshaqaq Hassan M. , Al-Qahtani Mohammad H. , Albuali Waleed H. 
Published: October 2022

INTRODUCTION:
The most common cause of death among sickle cell disease (SCD) patients is acute chest syndrome (ACS). Since SCD is a common condition in the Eastern province of the Kingdom of Saudi Arabia (KSA), we aimed to provide a detailed description of the clinical characteristics and ACS management.

METHODS:
We retrospectively studied pediatric (<14 years) patients with SCD diagnosis who were admitted with ACS or developed ACS after admission from January 2002 to December 2020. The absence of chest X-ray or hemoglobin electrophoresis was the reason to exclude patients from the study. The primary objective of the study was to evaluate and report the clinical, laboratory, and management characteristics of ACS.

RESULTS:
Ninety-one ACS episodes (42 patients) were included, with a mean diagnosis age of 7.18 ± 3.38 years. Twenty-two (52.4%) patients were male. Twenty-five patients had recurrent ACS episodes. The median absolute number of ACS was 3.5 (interquartile range [IQR], 2–9), with maximum ACS episodes of 13/1 year and a minimum of 1 ACS episode per year. At the first ACS episode, the mean age was 6.62 ± 3.38 years, while the overall mean age at ACS episode diagnosis was 7.18 ± 3.38 years. The most common antecedent events were vaso-occlusive crisis (12 episodes, 13.2%) and upper respiratory tract infections (8 episodes, 8.8%). The most frequently encountered presenting symptoms were fever (70.3%) and cough (70.3%). The most common antibiotics used were azithromycin (82.4%) and ceftriaxone (75.8%). Nine patients (9.9%) required pediatric intensive care unit (PICU) admission. Of the 91 ACS episodes, there was no in-hospital mortality. The median hospital and PICU length of stay were 8 days (IQR, 5–10.25) and 4 days (IQR, 3–5.5), respectively.

CONCLUSION:
This study has reported the most common clinical characteristics and management of ACS among pediatric SCD patients in the Eastern province of KSA.
Acceptability and feasibility of the Heartfulness Way: A social-emotional learning program for school-going adolescents in India
Authors: Shinde Sachin , Pereira Bernadette , Khandeparkar Prachi 
Published: October 2022

Background:
The interest in life skills education programs in schools is growing. Yet, there is limited evidence on implementation indicators for such programs in low-income countries.

Aim:
We present a qualitative evaluation of the acceptability and feasibility of the Heartfulness Way program—a secondary school-based social-emotional program, based on mindfulness techniques delivered by teachers in India.

Methods:
This qualitative study collected data from 12 schools in four Indian cities, namely, Chennai, Hyderabad, Prayagraj, and Pune. Data collection included focus group discussions with adolescents (n = 24) and teachers (n = 12), semistructured interviews with school principals (n = 12), program delivering teachers (n = 7), and program staff (n = 4). A thematic analysis was performed using NVivo 12.

Results:
Overall, the mindfulness-based classroom curriculum was strongly supported by participants. Acceptability was determined by positive responses, prosocial behavior, self-acceptance, and supportive bonds, according to students. Several themes of perceived benefits of the program including, improved relationships among peers and between students and teachers were identified. In general, the teachers’ interviews indicated that there was a high level of satisfaction with the training and curriculum provided by the program. Teachers were able to provide high coverage (75%–80%) of the program activities, but several potential barriers were also identified, including insufficient training for teachers and the need for direct supervision.

Conclusion:
The Heartfulness Way program, a social-emotional learning intervention, has shown strong support for acceptance and delivery by school communities. Future studies are needed to examine the effectiveness and cost-effectiveness of this program for improving the health and well-being of school-aged adolescents.
Suicide and suicidal ideation in the times of the Covid-19 pandemic: A scientometric analysis
Authors: Palod Rajat Jagdish , Joshi Mahika Milind , Kumar Rupali , Ligade Virendra Siddharam 
Published: October 2022

Objectives:
The article aims to explore the studies performed on suicide because of coronavirus disease 19 through a bibliometric analysis. A quantitative analysis of the topic furnishes data on the publication pattern, influential research journals, highly cited articles, productive countries and organizations, the authorship pattern, and the collaborative pattern between authors.

Methods:
Data regarding the type of documents, most cited articles, influential research journals, contributions per country, and so on were extracted for the study from the Scopus database. Data analysis and visualization were performed through R-Studio and the VOSviewer application.

Results:
A bibliometric analysis encompassing scientific contributions based on suicide or suicide-related ideation because of the coronavirus pandemic showed a total of 494 documents published in 230 journals/books. The articles published by proficient authors in reputed journals highlighted the key areas of research in the field. USA dominated the list of scientific production of countries contributing to 340 documents.

Conclusion:
The results provided by this analysis could act as a steppingstone for experts to design a roadmap for mental health research during the pandemic. Studies can be designed to gather information on mental health conditions across specific age groups. Research collaborations that facilitate the publication of pooled protocols and data are encouraged.
Impact of COVID-19 lockdown on substance availability, accessibility, pricing, and quality: A multicenter study from India
Authors: Arya Sidharth , Ghosh Abhishek , Mishra Shree , Swami Mukesh Kumar , Prasad Sambhu , Somani Aditya , Basu Aniruddha , Sharma Kshitiz , Padhy Susanta Kumar , Nebhinani Naresh , Singh Lokesh Kumar , Choudhury Shinjini , Basu Debasish , Gupta Rajiv 
Published: October 2022

Background and Aim:
Pandemic and consequent lockdowns are likely to affect the drug market by the sudden disruption of the supply chain. We explored the change in the availability, access, purity, and pricing during lockdown from respondents seeking treatment for drugs, alcohol, and tobacco dependence.

Materials and Methods:
A cross-sectional survey was conducted among 404 respondents from seven treatment centers across India. A structured questionnaire assessed the change in availability, access, quality, and price of substances used during the first phase (March 24–April 14) and the second phase (April 15–May 3) of lockdown.

Results:
A majority of the respondents in treatment used tobacco (63%) and alcohol (52%). Relatively few respondents used opioids (45%) or cannabis (5%). Heroin (44%) was the most common opioid the respondents were treated for. Seventy-five percent, 65%, and 60% of respondents treated for alcohol, tobacco, and opioid problems, respectively, reported a reduction in the availability and access during the first phase of the lockdown. In the second phase, respondents with alcohol and tobacco dependence reported greater availability than those with opioid and cannabis dependence. The reported price of all substances increased more than 50% during the first phase of lockdown and remained higher throughout the second phase. Deterioration in purity was reported by more than half of the people who used opioid.

Conclusion:
Lockdown could have affected both licit and illicit drug markets, albeit to a varying degree. The observed changes seemed short-lasting, as suggested by the recovering trends during the second phase of lockdown.
Metabolic Syndrome and Breast Cancer: Is There a Cause-and-Effect Relationship?
Authors: Negi Preety , Kingsley Pamela A. , Jacob Jubbin Jagan , Sachdeva Jaineet , Jomi Chinnu 
Published: October 2022

Background:
Metabolic syndrome (MetS) has an important role in the development as well as the progression of breast cancer (BC). This syndrome is defined as having three or more central obesity, hypertension, insulin resistance, low low-density lipoprotein cholesterol, and high triglycerides (TGs). Multiple studies have demonstrated that early recognition of MetS may have a positive impact on decreasing BC incidence. We compared the prevalence of MetS in newly diagnosed carcinoma breast patients with controls in the general population and thereby provide insight into its role as an emerging risk factor for BC.

Patients and Methods:
A prospective, case–control study was conducted at Christian Medical College and Hospital, Ludhiana, between September 2018 and October 2019. One hundred and four subjects each of BC and age-matched controls were enrolled. The measurement of waist circumference (WC), blood pressure (BP), fasting blood glucose levels, and lipid profile was performed for women with newly diagnosed BC and controls.

Results:
MetS was significantly more prevalent among BC (65.4%) compared to controls (30.8%). On assessing each component of MetS, it was evident that the prevalence of WC and BP, as well as the metabolic parameters, namely fasting blood sugar, TGs, and high-density lipoprotein cholesterol, was higher in Group A as compared to Group B. The majority of the women with BC and MetS were postmenopausal. The majority (66.2%) of BC patients with MetS were receptor positive.

Conclusions:
This study unveils a hidden link between MetS and BC, and hence, BC awareness programs should stress the need for lifestyle changes and healthy living to nip this evil in the bud. Opportunistic screening should be undertaken for women presenting to the medical facility with MetS. Future studies are required to design effective strategies to raise the possibility of MetS as an established risk factor in BC.
Predicting Cardiac Index Using the Electrocardiogram in Pulmonary Hypertension Patients
Authors: Mirtajaddini Marzieh , Naderi Nasim , Mohammadi Khadije , Taghavi Sepideh , Maharloo Maryam , Mazloomzadeh Saeideh , Amin Ahmad 
Published: October 2022

Background:
Pulmonary hypertension (PH) is a fatal disease where on-time treatment can change the prognosis. The selection of treatment is dictated by the severity of PH. The cardiac index (CI) is a robust indicator of PH severity. This trial aimed to find out the association between electrocardiogram (ECG) data and CI as a prognostic factor of PH.

Methods:
Ninety-five patients with precapillary PH were included in the study. The cardiac output of patients was calculated using the right heart catheterization and the Fick formula. Patients were categorized into low- and high-risk groups based on the CI. Their ECGs were interpreted by an expert cardiologist. The association between ECG parameters and severity of PH was evaluated based on the CI.

Results:
The median age of patients was 36 years. The mean of CI was 2.35 L/min/m2 with a standard deviation of 0.74. About 36% of patients were in the high-risk category based on the CI. Among ECG parameters, ST segment depression in V1-V6 and R/S ratio ≥1 in V1 were found significantly correlated with CI for high-risk category (P = 0.026).

Conclusion:
ST segment depression in V1-V6 and R/S ratio ≥1 in V1 had a significant association with CI in the range lower than 2 L/min/m2, which is an indicator of poor PH prognosis. Therefore, these variables can be used as an inexpensive and available prognostic factor in patients with precapillary PH.
A Clinical Trial of Comparing Dexmedetomidine and Remifentanil on the Oximetry Parameters in the Patients with End-Stage Renal Disease Undergoing Arteriovenous Fistula Formation
Authors: Dolatabadi Mahmoud Reza Mohaghegh , Motlagh Soudabeh Djalali , Ghodraty Mohamadreza , Shafeinia Amineh , Maleki Alireza , Norouzi Zeinab , Khaleghparast Shiva 
Published: October 2022

Background:
Oximetry is a method for measuring the arterial hemoglobin saturation (SpO2) using pulse oximeter and is essential in any type of anesthetic procedures. The growing population of geriatrics in the recent decades in combination with an increase in the prevalence of chronic diseases including diabetes and hypertension are some of the leading causes for an increase in the prevalence of chronic kidney disease and end-stage renal disease (ESRD). The definite treatment for ESRD is renal transplant but unfortunately, it may take a long time to find a suitable kidney and continuing the patient's life may depend on dialysis. Arteriovenous fistula (AVF) formation is one of the first steps to prepare the patient for hemodialysis. ESRD itself is a reason for physical and psychosocial issues. Preparing a favorable condition for AVF surgery is essential to decrease the burden of the underlying disease. An efficient respiratory supply is necessary in all parts of an anesthetic procedures.

Aims and Objectives:
This study is a double-blind clinical trial to compare two anesthetic agents, dexmedetomidine and remifentanil in patients with ESRD who underwent AVF formation.

Materials and Methods:
SpO2 was measured on different phases including the time of initial incision, and after 10, 30, 60, 90, and 120 min of finishing the surgery. The data were analyzed using SPSS version 22, two-way repeated measures (ANOVA), and independent t-test.

Results:
This study showed that there was no any significant difference in using any of these two agents with regard to SpO2 in the different times of measurements during the anesthetic procedure and after the surgery in the recovery phase.

Conclusion:
This study showed that there is not any superiority in using DEX or REM in the patients undergo AVF formation. More studies on the other groups of the patients with different surgeries.
An Augmented Reality-Based Approach for Designing Interactive Food Menu of Restaurant Using Android
Authors: Amin Sadia Nur , Shivakumara Palaiahnakote , Jun Tang Xue , Chong Kai Yang , Zan Dillon Leong Lon , Rahavendra Ramachandra 
Published: October 2022

The food industry is becoming competitive on a daily basis and introducing newer cuisines to the menu in an attempt to rise up the ladder. But they still are not being able to improve their performances because customers often only have the waiters to describe the dishes to them and thus, most of the time results in not fulfilling their expectations. Thus, to allow the customers to visualize their orders more informatively, this paper presents an android application that overlays digital three-dimensional (3D) food models onto a quick responsible (QR) code image marker on a food menu using augmented reality (AR) technology through the camera of the system. Moreover, the price and a detailed list of the ingredients used to prepare the dish, along with the nutritional and calorie content, will also appear beside the 3D food model to keep the customers completely informed of what they will be ordering. This work focused on designing the 3D food models in the Blender 3D tool, which were then imported into the Unity 3D application with the Vuforia software development kit preinstalled, and Figma has been utilized for designing the user interface of the system. The study’s outcome is an AR application that provides the customer with a more engaging approach to visualize the dishes in 3D form, which can improve customer sales and restaurant loyalty.

Received: 15 August 2022 | Revised: 4 October 2022 | Accepted: 10 October 2022

Conflicts of Interest
Palaiahnakote Shivakumara is an Editor-in-Chief and Ramachandra Rahavendra is an Advisory Board Member for Artificial Intelligence and Applications, and were not involved in the editorial review or the decision to publish this article. The authors declare that they have no conflicts of interest to this work.
Bta-miR-33a affects gene expression and lipid levels in Chinese Holstein mammary epithelial cells
Authors: Jiang Ping , Iqbal Ambreen , Cui Zhiqian , Yu Haibin , Zhao Zhihui 
Published: October 2022

Abstract. MicroRNAs (miRNAs) are non-coding single-stranded RNA molecules of about
19–25 nucleotides in length that regulate different biological processes,
including lipid metabolism. In this study, we explored the effect of
bta-miR-33a on lipid metabolism in bovine mammary epithelial cells (BMECs)
of Chinese Holstein for the first time. For this purpose, the plasmids of
bta-miR-33a mimic, bta-miR-33a inhibitor and bta-miR-33a negative control
were constructed to overexpress or repress bta-miR-33a in BMECs. The effects of
plasmid transfection were analysed by examining the mRNA and protein
expression levels of ELOVL6 and the intracellular triglycerides. The results
showed that bta-miR-33a directly inhibited the expression of ELOVL6 in BMECs;
decreased the mRNA levels of ELOVL5, HACD2, CPT1A and MSMO1; and increased the mRNA level of ALOX15.
Sequence bta-miR-33a also increased the contents of triglycerides in the cells,
presumably as a consequence of these gene expression changes. In summary,
the results of the present study suggest that bta-miR-33a regulates lipid
metabolism by targeting ELOVL6, which might be a potential molecular marker of
milk fat composition.
Canadian forest fires, Icelandic volcanoes and increased local dust observed in six shallow Greenland firn cores
Authors: Kjær Helle Astrid , Zens Patrick , Black Samuel , Lund Kasper Holst , Svensson Anders , Vallelonga Paul 
Published: October 2022

Abstract. Greenland ice cores provide information about past climate. Few impurity
records covering the past 2 decades exist from Greenland. Here we present
results from six firn cores obtained during a 426 km long northern Greenland traverse made in 2015 between the NEEM and the EGRIP deep-drilling stations situated on the western side and eastern side of the Greenland ice sheet, respectively. The cores (9 to 14 m long) are analyzed for chemical impurities and cover time spans of 18 to 53 years (±3 years) depending on local snow accumulation that decreases from west to east. The high temporal resolution allows for annual layers and seasons to be
resolved. Insoluble dust, ammonium, and calcium concentrations in the six firn cores overlap, and the seasonal cycles are also similar in timing and
magnitude across sites, while peroxide (H2O2) and conductivity
both have spatial variations, H2O2 driven by the accumulation
pattern, and conductivity likely influenced by sea salt. Overall, we determine a rather constant dust flux over the period, but in
the data from recent years (1998–2015) we identify an increase in large dust particles that we ascribe to an activation of local Greenland sources. We observe an expected increase in acidity and conductivity in the mid-1970s as a result of anthropogenic emissions, followed by a decrease due to mitigation. Several volcanic horizons identified in the conductivity and acidity records can be associated with eruptions in Iceland and in the Barents Sea region. From a composite ammonium record we obtain a robust forest fire proxy associated primarily with Canadian forest fires (R=0.49).
Atmospheric rotating rig testing of a swept blade tip and comparison with multi-fidelity aeroelastic simulations
Authors: Barlas Thanasis , Pirrung Georg Raimund , Ramos-García Néstor , González Horcas Sergio , Li Ang , Madsen Helge Aagaard 
Published: October 2022

Abstract. One promising design solution for increasing the energy production of modern horizontal axis wind turbines is the installation of curved tip extensions. However, since the aeroelastic response of such geometrical add-ons has not been characterized yet, there are currently uncertainties in the application of traditional aerodynamic numerical models. The objective of the present work is twofold. On the one hand, it represents the first effort in the experimental characterization of curved tip extensions in atmospheric flow. On the other hand, it includes a comprehensive validation exercise, accounting for different numerical models for aerodynamic load prediction. The experiments consist of controlled field tests at the outdoor rotating rig at the Risø campus of the Technical University of Denmark (DTU), and consider a swept tip shape. This geometry is the result of an optimized design, focusing on locally maximizing power performance within load constraints compared to an optimal straight tip. The tip model is instrumented with spanwise bands of pressure sensors and is tested in atmospheric inflow conditions. A range of fidelities of aerodynamic models are then used to aeroelastically simulate the test cases and to compare with the measurement data. These aerodynamic codes include a blade element momentum (BEM) method, a vortex-based method coupling a near-wake model with a far-wake model (NW), a lifting-line hybrid wake model (LL), and fully resolved Navier–Stokes computational fluid dynamics (CFD) simulations. Results show that the measured mean normal loading can be captured well with the vortex-based codes and the CFD solver. The observed trends in mean loading are in good agreement with previous wind tunnel tests of a scaled and stiff model of the tip extension. The CFD solution shows a highly three-dimensional flow at the very outboard part of the curved tip that leads to large changes of the angle of the resultant force with respect to the chord. Turbulent simulations using the BEM code and the vortex codes resulted in a good match with the measured standard deviation of the normal force, with some deviations of the BEM results due to the missing root vortex effect.
Participação, representação e representatividade dos povos e comunidades tradicionais nos Conselhos Estaduais de Recursos Hídricos da Amazônia Oriental
Authors: Da Silva Jaqueline Maria Soares , Pontes Altem Nascimento 
Published: October 2022

Este artigo apresenta análise da participação, representação e representatividade dos Povos e Comunidades Tradicionais (PCT) nos Conselhos Estaduais de Recursos Hídricos (CERH) da Amazônia Oriental, com o objetivo de verificar se tais espaços têm sido palco de debates, de defesa dos interesses coletivos e de decisões relevantes a essas populações. Para tanto foi realizada pesquisa documental referente às leis, decretos, regimentos, resoluções e atas publicados entre os anos de 1997 e 2022, nos sites das Secretarias de Meio Ambiente dos estados do Amapá, Maranhão, Mato Grosso, Pará e Tocantins, resultando na identificação e análise de 34 mandatos, 23 decretos de regulamentação, 169 resoluções e 93 atas. Os resultados obtidos mostraram que os conselhos do Amapá, Tocantins e Maranhão não possuem em seus decretos a previsão de vagas para os PCT, diferentemente dos conselhos do Pará e do Mato Grosso, em que foi identificada a definição de vagas para os representantes dos PCT, porém estes não estiveram presentes em 88,89 e 100% das reuniões realizadas, respectivamente. Ao fim, constatou-se que a previsão de vagas aos representantes dos PCT nos conselhos não garante a efetiva participação e a representatividade, sendo premente o desenvolvimento de estratégias que possam promover a inclusão e a participação plena dos PCT nos CERH da Amazônia Oriental.