bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the clinical utility of MMPI‐2‐RF interpersonal theory of suicide proxy indices in psychiatric hospitalization setting
Authors: Khazem Lauren R. , Anestis Joye C. , Rufino Katrina A. 
Published: April 2022

AbstractIntroductionThe Minnesota Multiphasic Personality Inventory‐2‐Restructured Form (MMPI‐2‐RF Ben‐Porath & Tellegen, 2008/2011) has been applied to suicide risk assessment through derived proxy indices of perceived burdensomeness, thwarted belongingness, and the acquired capability for suicide (Anestis et al., 2018, Joiner, 2005). However, limited research has examined the clinical utility of these proxy indices outside the outpatient setting. This study examined the performance of these proxy indices in identifying past‐month suicide ideation intensity and attempts upon admission to a psychiatric inpatient program and changes in suicidal ideation intensity at discharge. We expected these indices and their interaction would be associated with suicide ideation intensity and attempts at baseline and with a lack of significant improvement in suicide ideation intensity at discharge, including when controlling for MMPI‐2‐RF Suicide/Death Ideation (SUI) scale scores.MethodParticipants were 1007 patients in a private inpatient psychiatric hospital in the southwestern United States, 968 of whom completed study measures at admission and discharge. Participants were administered the C‐SSRS and MMPI‐2‐RF upon admission, while the C‐SSRS was administered again prior to discharge. A series of moderation analyses were conducted to examine the main and interaction effects of the MMPI‐2‐RF derived proxy indices on suicidal ideation intensity and suicide attempts at admission. Logistic regression analyses were conducted to examine whether MMPI‐2‐RF proxy index scores at admission were associated with changes in suicidal ideation intensity at discharge.ResultsNeither the proxy indices nor their interaction was associated with all study outcomes. The acquired capability for suicide proxy index and its interaction with other indices were not associated with suicide attempt status at admission. However, high thwarted belongingness proxy index scores were associated with greater suicidal ideation intensity at admission; high perceived burdensomeness proxy index scores were indicative of a lack of significant change in suicide ideation intensity at discharge.ConclusionThese results indicate a need to further examine these proxy indices in high acuity samples.
Analyzing real world data of blood transfusion adverse events: Opportunities and challenges
Authors: Jhaveri Perrin , Bozkurt Selen , Moyal Axel , Belov Artur , Anderson Steven , Shan Hua , Whitaker Barbee , Hernandez‐Boussard Tina 
Published: April 2022

AbstractBackgroundBlood transfusions are a vital component of modern healthcare, yet adverse reactions to blood product transfusions can cause morbidity, and rarely result in mortality. Therefore, accurate reporting of transfusion related adverse events (TRAEs) is paramount to improved transfusion practice. This study aims to investigate real‐world data (RWD) on TRAEs by evaluating differences between ICD 9/10‐based electronic health records (EHR) and blood bank‐specific reporting.Study Design and MethodsTRAE data were retrospectively collected from a blood bank‐specific database between Jan 2015 and June 2019 as the reference data source and compared it to ICD 9/10 diagnostic codes corresponding to various TRAEs. Seven reactions that have corresponding ICD 9/10 diagnostic codes were evaluated: Transfusion related circulatory overload (TACO), transfusion related acute lung injury (TRALI), febrile non‐hemolytic reaction (FNHTR), transfusion‐related anaphylactic reaction (TRA), acute hemolytic transfusion reaction (AHTR), delayed hemolytic transfusion reaction (DHTR), and delayed serologic reaction (DSTR). These accounted for 33% of the TRAEs at an academic institution during the study period.ResultsAmong 18637 adult blood transfusion recipients, there were 229 unique patients with 263 TRAE related ICD codes in the EHR, while there were 191 unique patients with 287 TRAEs identified in the blood bank database. None of the categories of reaction we investigated had perfect alignment between ICD 9/10 codes and blood bank specific diagnoses.DiscussionMultiple systemic challenges were identified that hinder effective reporting of TRAEs. Identifying factors causing inconsistent reporting between blood banks and EHRs is paramount to developing effective workability between these electronic systems, as well as across clinical and laboratory teams.
Preoperative skin asepsis protocols using chlorhexidine versus povidone‐iodine in veterinary surgery: A systematic review and meta‐analysis
Authors: Marchionatti Emma , Constant Caroline , Steiner Adrian 
Published: April 2022

AbstractObjectiveTo provide a systematic assessment of the efficacy of preoperative skin asepsis using chlorhexidine versus povidone‐iodine based protocols for surgical site infection (SSI) prevention in veterinary surgery.Study designSystematic meta‐analytical review according to PRISMA‐P guidelines.Sample populationStudies comparing preoperative skin asepsis protocols using chlorhexidine versus povidone‐iodine in veterinary surgery identified by systematic search between 1990 and 2020.MethodsA search using MEDLINE/Pubmed, Web of Science and CAB Abstracts was performed, followed by secondary searches of Google Scholar, Proquest Dissertation and Theses, and relevant bibliographic articles. Primary and secondary outcome measures were the efficacy of skin asepsis protocols using chlorhexidine versus povidone‐iodine on SSI incidence and skin bacterial colonization, respectively. A meta‐analysis was performed with a random‐effect model, with effect size calculated as risk ratio (RR) or mean standard deviation (MSD) with 95% CI. Statistical significance was set at P < .05.ResultsAmong 1067 publications that met the initial search criteria, 9 relevant studies were eligible for analysis. No difference in the incidence of postoperative SSI or skin bacterial colonization between preoperative asepsis protocols using chlorhexidine versus povidone‐iodine was found. Insufficient information and detail were frequent among studies and precluded a clear assessment of bias.ConclusionThis study showed that asepsis protocols using chlorhexidine were comparable to povidone‐iodine in preventing postoperative SSI and reducing skin bacterial colonization.Clinical significanceGiven the limitations of the studies that were included in terms of both quality and quantity, more high‐quality randomized controlled trials are needed to confirm these conclusions.
Protocol for the COG-UK hospital-onset COVID-19 infection (HOCI) multicentre interventional clinical study: evaluating the efficacy of rapid genome sequencing of SARS-CoV-2 in limiting the spread of COVID-19 in UK NHS hospitals
Authors: Blackstone James , Stirrup Oliver , Mapp Fiona , Panca Monica , Copas Andrew , Flowers Paul , Hockey Leanne , Price James , Partridge David , Peters Christine , de Silva Thushan , Nebbia Gaia , Snell Luke B , McComish Rachel ,   The COVID-19 Genomics UK (COG-UK) Consortium, Breuer Judith 
Published: April 2022

ObjectivesNosocomial transmission of SARS-CoV-2 has been a significant cause of mortality in National Health Service (NHS) hospitals during the COVID-19 pandemic. The COG-UK Consortium Hospital-Onset COVID-19 Infections (COG-UK HOCI) study aims to evaluate whether the use of rapid whole-genome sequencing of SARS-CoV-2, supported by a novel probabilistic reporting methodology, can inform infection prevention and control (IPC) practice within NHS hospital settings.DesignMulticentre, prospective, interventional, superiority study.Setting14 participating NHS hospitals over winter–spring 2020/2021 in the UK.ParticipantsEligible patients must be admitted to hospital with first-confirmed SARS-CoV-2 PCR-positive test result >48 hour from time of admission, where COVID-19 diagnosis not suspected on admission. The projected sample size is 2380 patients.InterventionThe intervention is the return of a sequence report, within 48 hours in one phase (rapid local lab processing) and within 5–10 days in a second phase (mimicking central lab), comparing the viral genome from an eligible study participant with others within and outside the hospital site.Primary and secondary outcome measuresThe primary outcomes are incidence of Public Health England (PHE)/IPC-defined SARS-CoV-2 hospital-acquired infection during the baseline and two interventional phases, and proportion of hospital-onset cases with genomic evidence of transmission linkage following implementation of the intervention where such linkage was not suspected by initial IPC investigation. Secondary outcomes include incidence of hospital outbreaks, with and without sequencing data; actual and desirable changes to IPC actions; periods of healthcare worker (HCW) absence. Health economic analysis will be conducted to determine cost benefit of the intervention. A process evaluation using qualitative interviews with HCWs will be conducted alongside the study.Trial registration numberISRCTN50212645. Pre-results stage. This manuscript is based on protocol V.6.0. 2 September 2021.
Effect of a multicomponent intervention in postnatal mothers’ groups on meeting the Australian Physical Activity Guidelines for infants: protocol for a randomised controlled trial
Authors: Hewitt Lyndel , Frohmuller Carolyn , Wen Li Ming , Okely Anthony D 
Published: April 2022

IntroductionGiven the importance of tummy time and the low levels of tummy time reported globally, there is a need for high-quality intervention strategies to promote tummy time. This study describes the protocol of a randomised controlled trial that aims to determine the effectiveness of a multicomponent intervention delivered in postnatal mothers’ groups in increasing infant tummy time.Methods and analysisA randomised controlled trial will be conducted. Eligible participants will be mothers and their infants attending postnatal mothers’ groups (New South Wales, Australia). Participants will be randomised to participate in either (1) infant tummy time intervention group (practice, education, WhatsApp) plus usual care; or (2) usual care group. Randomisation process and outcome assessors will be blinded. The intervention will comprise an online education and practice session (60 min) and 4 weeks of WhatsApp messaging (standardised, three times per week). Usual care will be attendance at a mothers group once per week for 3 weeks for information and support for ad hoc mother craft activities (standard practice provided by early childhood nurses for this local health district). The primary outcome will be the amount of infant tummy time using the GENEActiv accelerometer and a questionnaire (post intervention). The accelerometer will be worn on the right hip secured by an elastic belt around the waist. Wear and non-wear time will be classified using temperature and z-axis cut points as per previous research. This protocol paper presents the scientific background and proposed methods of the randomised controlled trial. Findings will inform the design of practically based strategies to inform clinicians, educators and parents about infant physical activity.Ethics and disseminationThe University of Wollongong and Illawarra Shoalhaven Local Health District Health and Medical Human Research Ethics Committee approved the study (2020/ETH02970). Dissemination plan is publication, staff training and conference presentations.Trial registration numberAustralian New Zealand Clinical Trials Registry ACTRN12621000575831; Pre-results.
Coronary calcium scoring as first-line test to detect and exclude coronary artery disease in patients presenting to the general practitioner with stable chest pain: protocol of the cluster-randomised CONCRETE trial
Authors: Koopman Moniek Y , Reijnders Jorn J W , Willemsen Robert T A , van Bruggen Rykel , Doggen Carine J M , Kietselaer Bas , Oude Wolcherink Martijn J , van Ooijen Peter M A , Gratama Jan Willem C , Braam Richard , Oudkerk Matthijs , van der Harst Pim , Dinant Geert-Jan , Vliegenthart Rozemarijn 
Published: April 2022

IntroductionIdentifying and excluding coronary artery disease (CAD) in patients with atypical angina pectoris (AP) and non-specific thoracic complaints is a challenge for general practitioners (GPs). A diagnostic and prognostic tool could help GPs in determining the likelihood of CAD and guide patient management. Studies in outpatient settings have shown that the CT-based coronary calcium score (CCS) has high accuracy for diagnosis and exclusion of CAD. However, the CT CCS test has not been tested in a primary care setting. In the COroNary Calcium scoring as fiRst-linE Test to dEtect and exclude coronary artery disease in GPs patients with stable chest pain (CONCRETE) study, the impact of direct access of GPs to CT CCS will be investigated. We hypothesise that this will allow for early diagnosis of CAD and treatment, more efficient referral to the cardiologist and a reduction of healthcare-related costs.Methods and analysisCONCRETE is a pragmatic multicentre trial with a cluster randomised design, in which direct GP access to the CT CCS test is compared with standard of care. In both arms, at least 40 GP offices, and circa 800 patients with atypical AP and non-specific thoracic complaints will be included. To determine the increase in detection and treatment rate of CAD in GP offices, the CVRM registration rate is derived from the GPs electronic registration system. Individual patients’ data regarding cardiovascular risk factors, expressed chest pain complaints, quality of life, downstream testing and CAD diagnosis will be collected through questionnaires and the electronic GP dossier.Ethics and disseminationCONCRETE has been approved by the Medical Ethical Committee of the University Medical Center of Groningen.Trial registration numberNTR 7475; Pre-results.
Willingness for community-based and institutional eldercare among older adults: a cross-sectional study in Zhejiang, China
Authors: Wang Hao , Guan Yunqi , Hu Ruying , Bragg Fiona , Yu Min , Zhong Jieming 
Published: April 2022

ObjectiveTo investigate the proportion of willingness for community-based and institutional care and their correlating factors among older adults in Zhejiang Province, China.DesignCross-sectional study.SettingThe Sixth National Health Service Survey, carried out in Zhejiang, China.Participants7300 eligible older adults aged 60 years or older.Main outcomes measuresWillingness for community-based and institutional eldercare.ResultsThe average age of the participants was 69.0±7.3 years. 50.9% of the participants were males, and 49.1% were females. 19.2% came from urban areas and 80.8% were from rural areas. The percentage of willingness for community-based and institutional eldercare was 2.7% and 3.8%, respectively. The corresponding figures for females were 2.9% and 3.5%, respectively, and for males were 2.5% and 4.1%, respectively. Factors positively associated with willingness for community-based eldercare included living in urban areas, high educational attainment, more frequent active exercise and living alone. Factors positively associated with willingness for institutional eldercare included age, living at urban areas, high education attainment, more frequent active exercise and receiving assistance with daily living.ConclusionsFamily eldercare was the priority for older adults compared with community-based and institutional eldercare in Zhejiang. The willingness for community-based and institutional eldercare among older adults was affected not only by the older adults themselves, but also by community and family members.
Gastric cancer completeness in Finnish Cancer Registry and Finnish Patient Registry: a population-based nationwide retrospective cohort study
Authors: Maharjan Urgena , Kauppila Joonas H 
Published: April 2022

BackgroundGastric cancer is the fourth-leading cause of cancer-related deaths worldwide. The only curative treatment options of gastric cancer are perioperative chemotherapy and surgical resection. Many nationwide registries have high validity and provide vast range of opportunities for registry-based research. Cancer diagnoses in the Finnish Cancer Registry (FCR) are reported by pathology laboratories and clinician forms, while discharge diagnosis codes are reported to the Finnish Patient Registry (HILMO) automatically. Finland is known for complete registries but the completeness of gastric cancer in FCR and HILMO remains unclear.ObjectivesThe aim of this study is to assess the registry coverage for gastric cancer in FCR and HILMO and to explore potential reasons for possible differences between these registries.DesignPopulation-based nationwide retrospective cohort study.ParticipantsAll patients diagnosed with gastric cancer in Finland during 1990 to 2014, with follow-up until 31 December 2019.ResultsOut of 21 468 total gastric cancers reported to either registry, 17 107 (79.7%) had a gastric cancer diagnosis in both registries. A substantial decrease from 88.3% to 83.4% was observed in the proportion of cases reported to FCR over time. The completeness of FCR was estimated at 87%. For HILMO, the completeness was 92.7%. Death due to gastric cancer was most common in those with gastric cancer in both registries (80.8%), and less common in those reported to only FCR (36.3%), followed by those reported to only HILMO (9.3%).ConclusionsThe study indicates that gastric cancer is well captured by both FCR and HILMO but there is an alarming decrease in the proportion of cases captured by the FCR over time. Some gastric cancer diagnoses in HILMO might, however, be misclassified due to cancer diagnoses being assigned based on clinical suspicion.
Identifying modifiable risk factors for mortality in children aged 1–59 months admitted with WHO-defined severe pneumonia: a single-centre observational cohort study from rural Malawi
Authors: Eckerle Michelle , Mvalo Tisungane , Smith Andrew G , Kondowe Davie , Makonokaya Don , Vaidya Dhananjay , Hosseinipour Mina C , McCollum Eric D 
Published: April 2022

ObjectiveAlthough HIV infection, severe malnutrition and hypoxaemia are associated with high mortality in children with WHO-defined severe pneumonia in sub-Saharan Africa, many do not have these conditions and yet mortality remains elevated compared with high-resource settings. Further stratifying mortality risk for children without these conditions could permit more strategic resource utilisation and improved outcomes. We therefore evaluated associations between mortality and clinical characteristics not currently recognised by the WHO as high risk among children in Malawi with severe pneumonia but without HIV (including exposure), severe malnutrition and hypoxaemia.MethodsBetween May 2016 and March 2018, we conducted a prospective observational study alongside a randomised controlled trial (CPAP IMPACT) at Salima District Hospital in Malawi. Children aged 1–59 months hospitalised with WHO-defined severe pneumonia without severe malnutrition, HIV and hypoxaemia were enrolled. Study staff assessed children at admission and ascertained hospital outcomes. We compared group characteristics using Student’s t-test, rank-sum test, χ2 test or Fisher’s exact test as appropriate.ResultsAmong 884 participants, grunting (10/112 (8.9%) vs 11/771 (1.4%)), stridor (2/14 (14.2%) vs 19/870 (2.1%)), haemoglobin <50 g/L (3/27 (11.1%) vs 18/857 (2.1%)) and malaria (11/204 (5.3%) vs 10/673 (1.4%)) were associated with mortality compared with children without these characteristics. Children who survived had a 22 g/L higher mean haemoglobin and 0.7 cm higher mean mid-upper arm circumference (MUAC) than those who died.ConclusionIn this single-centre study, our analysis identifies potentially modifiable risk factors for mortality among hospitalised Malawian children with severe pneumonia: specific signs of respiratory distress (grunting, stridor), haemoglobin <50 g/L and malaria infection. Significant differences in mean haemoglobin and MUAC were observed between those who survived and those who died. These factors could further stratify mortality risk among hospitalised Malawian children with severe pneumonia lacking recognised high-risk conditions.
Community paediatricians’ experience of joint working with child and adolescent mental health services: findings from a British national survey
Authors: Ani Cornelius , Ayyash Hani F , Ogundele Michael Oladipo 
Published: April 2022

ObjectivesChildren and young people (CYP) presenting to paediatric or child and adolescent mental health services (CAMHS) often have needs spanning medical and psychiatric diagnoses. However, joint working between paediatrics and CAMHS remains limited. We surveyed community paediatricians in the UK to inform better strategies to improve joint working with CAMHS.MethodsWe conducted an online survey of community paediatricians through the British Association for Community Child Health (BACCH) on how much joint working they experienced with CAMHS, any hindrances to more collaborative working, and the impact on service users and service provision. This paper is based on thematic analysis of 327 free-text comments by paediatricians.ResultsA total of 245 community paediatricians responded to the survey (22% of BACCH members). However, some responses were made on behalf of teams rather than for individual paediatricians. The following were the key themes identified: a strong support for joint working between community paediatrics and CAMHS; an acknowledgement that current levels of joint working were limited; the main barriers to joint working were splintered commissioning and service structures (eg, where integrated care systems fund different providers to meet overlapping children’s health needs); and the most commonly reported negative impact of non-joint working was severely limited access to CAMHS for CYP judged by paediatricians to require mental health support, particularly those with autism spectrum disorder.ConclusionThere is very limited joint working between community paediatrics and CAMHS in the UK, which is associated with many adverse impacts on service users and providers. A prointegration strategy that includes joint commissioning of adequately funded paediatric and CAMHS services that are colocated and within the same health management organisations is crucial to improving joint working between paediatrics and CAMHS.
Comment on ″Optical soliton to multi-core (coupling with all the neighbors) directional couplers and modulation instability″ [Eur.Phys.J.Plus(2021)136:325]
Authors: El-Ganaini Shoukry 
Published: April 2022

AbstractIn a recent paper, Abbagari et al. (EPJP 136:325, 2021) investigated the nonlinear multi-core coupler (coupling with all neighbors) with the parabolic law nonlinearity via the so called new sub-ODE method. In this comment, we show that all solutions presented by Abbagari et al. (EPJP 136:325, 2021) do not satisfy the considered equation and therefore are incorrect. Some important attentions to the authors (EPJP 136:325, 2021) have been presented.
Dirichlet problem for complex Monge–Ampère equation near an isolated KLT singularity
Authors: Fu Xin 
Published: April 2022

We solve the Dirichlet problem for complex Monge–Ampère equation near an isolate Klt singularity, which generalizes the result of Eyssidieux et al. [Singular Kähler–Einstein metrics, J. Amer. Math. Soc. 22 (2009) 607–639], where the Monge–Ampère equation is solved on singular varieties without boundary. As a corollary, we construct solutions to Monge–Ampère equation with isolated singularity on strongly pseudoconvex domain [Formula: see text] contained in [Formula: see text].