bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long term anti-vascular endothelial growth factor receptor treatment impairs renal function in renal cell carcinoma
Authors: Otake Kotaro , Naito Sei , Kato Tomoyuki , Narisawa Takafumi , Fukuhara Hiroki , Takai Yuki , Ushijima Masaki , Yagi Mayu , Nishida Hayato , Tsuchiya Norihiko 
Published: November 2022

Abstract
Background: The overall survival has been dramatically improving in metastatic renal cell carcinoma (mRCC) patients. Although anti-vascular endothelial growth factor receptor (VEGFR) treatment is one of essential therapeutic strategies for mRCC, the impact on renal function during their lifetime remains unclear. This study aimed to assess the comparison between the duration of anti-VEGFR treatment and chronic kidney disease (CKD) progression.
Methods:A total of 147 mRCC patients who started systemic therapy in Yamagata University Hospital from November 2005 to December 2018 were included in the study. We analyzed the probability of progression to CKD grades 4 and 5 using the Kaplan–Meier method and the log-rank test. To identify the factors independently associated with progression to CKD grade 4, multivariate analysis using logistic regression was performed with baseline eGFR, follow-up duration, duration with anti-VEGFR treatment, proteinuria, hypertension, and diabetes mellitus as the exposure variables.
Results: No patients with normal baseline renal function progressed to CKD grade 4 or 5. Two out of 85 patients with baseline CKD grade 3 progressed to grade 5 8 years after the start of the treatment. Three of five patients with baseline CKD grade 4 progressed to grade 5 within 2 years of starting the treatment. The estimated probability of the patients progressing to grade 4 was increased with worsening baseline CKD grade as determined by univariate analysis (P < 0.001). Multivariate analysis showed that baseline eGFR (P = 0.002), the duration of anti-VEGFR treatment (P = 0.014) and DM (P = 0.040) were independently correlated with progression to CKD grade 4.
Conclusions: Long-term anti-VEGFR treatment could impair renal function in mRCC patients with baseline CKD grade 3 or worse.
Naringin mitigates Bisphenol A-induced hepatotoxicity in cockerel chicks
Authors: Esuola Leah Oluwaseyanu , Esan Oluwaseun , Maikifi Adamu Shafiu , Ajibade Temitayo Olabisi , Adetona Moses Olusola , Oyagbemi Ademola Adetokunbo , Omobowale Temidayo Olutayo , Oladele Omolade Abodunrin , Oguntibeju Oluwafemi Omoniyi , Yakubu Momoh Audu 
Published: November 2022

Abstract
Bisphenol A (BPA) is an environmental pollutant, a monomer used in the polymer industry to produce plastics. BPA has been reported to cause deleterious effects in both humans and animals. Naringin is one of the flavonoids with antioxidant and metal chelating properties. This study was carried out to assess the potential ameliorative effect of naringin on BPA-induced hepatotoxicity in cockerel chicks. Thirty-one-day old cockerel chicks used for this study were randomly divided into 6 groups of five chicks per group as follows: Group 1 (Control), Group 2 (BPA 100 mg/kg), Group 3 (BPA + 100 mg/kg naringin), Groups 4 (BPA + 200 mg/kg naringin), Group 5 (100 mg/kg naringin) and Group 6 (100 mg/kg naringin), respectively. The administration of BPA and naringin was through oral gavage. BPA intoxication precipitated significant (p < 0.05) increased ALT, ALP, AST, TC, TG, LDL, but decreased total protein and HDL-cholesterol when compared with the control. Also, there was a significant increase in hepatic H2O2 generation and MDA content with concomitant decrease in reduce glutathione, glutathione S-transferase, and superoxide dismutase activity in BPA intoxicated chicks. Histology revealed a moderate diffuse sinusoidal congestion, with a severe periportal cellular infiltration in BPA intoxicated chicks. Immunohistochemistry results revealed a higher expression of hepatic caspase 3 and TNF-α in chicks exposed to BPA alone relative to the control and chicks treated with naringin (100 mg/g and 200 mg/kg). Findings from this study showed that naringin administration restored hepatoxicity, improved antioxidant status, and lowered exaggerated values of cholesterol, oxidative stress indices, and ameliorated ultrastructure anarchy. Combining all, the incorporation of naringin into poultry feeds could position the flavonoid as a novel antioxidant and metal chelator with beneficial effects in the reduction of toxicities associated with environmental pollutants such as bisphenol A, thereby boosting production efficiency in livestock production.
Effects of Drilling Fluid Rheology on Nonlinear ALTC Vibration Response Characteristic of Rotary Drill String
Authors: Liu Jun , Chen Yili , Liang Shuang , Cai Mengqi 
Published: November 2022

Abstract
The drilling mud shows strong non-Newtonian rheology due to mixing a large number of cuttings at well bottom during drilling, which has great influences on the vibration behavior of the drill string. To investigate this phenomenon, an axial-lateral-torsion coupling (ALTC) nonlinear dynamic model based on Hamilton's principle was established, taking into account the effect of drilling fluid viscous damping, Herschel-Bulkley non-Newtonian rheological (HBNR) damping, bit-rock interaction and drillstring-borehole contact. In the model, a Rayleigh damping matrix calculation method was proposed to describe the influence of drilling fluid on the damping of ALTC vibration, and the Newmark-β method was used to solved the nonlinear discrete equations of the system. The validity of the model was verified through the simulation data and the field measurement data. Using the nonlinear model, the effect of drilling fluid rheology on ALTC vibration response of rotary drill string was investigated. It was found that compared with viscous damping, HBNR damping can significantly suppress the axial, lateral and torsional vibration of drill string, maintain the stability of wellbore diameter and improve ROP. Both damping models indicate that lateral vibration signals are difficult to transmit to the wellhead, while axial vibration and torsional vibration signals can be observed near the wellhead. The results can provide a theoretically guidance for suppressing the drill string vibration and reducing the risk of premature failure of drill string.
Racial Disparity and Temporal Patterns in Time to Invasive Ventilation During the COVID-19 Pandemic (Jan 2020 to Feb 2022)
Authors: Menon Nirup , Antonescu Corneliu , Leslie Timothy , Frankenfeld Cara , Garcia-Filion Pamela 
Published: November 2022

Abstract
· Background: The COVID-19 pandemic has significantly stressed the healthcare system since January 2020. There are questions whether there were racial disparities in the use of resources and procedures during this period and if so, did the disparities change over the pandemic. We focus on invasive ventilation (Mechanical Ventilation/MV and Extracorporeal Membrane Oxygenation/ECMO) and racial identity of the patient for the pre-Delta and Delta timeframes.
· Methods: We used data available from the National COVID Cohort Collaborative (N3C) of COVID positive patients across the US. Cox regression models were used to estimate time to MV and ECMO as the dependent variables and race, age, gender, Comorbidity index as covariates.
· Results: We did not find systematic patterns of racial disparity in time to MV. Asian and Hispanic patients, but not Black patients, received MV in a delayed manner compared to White patients in the pre-Delta period. These differences were not evident in the Delta period.
· Conclusions: The results show a temporal change from the pre-Delta and Delta timeframes for the time to invasive ventilation implying that any observed racial disparities improved over time. We did not find statistically significant differences in the time to ECMO across the races or over timeframes.
SCARB1 downregulation in adrenal insufficiency with Allgrove Syndrome
Authors: Bitetto Giacomo , Lopez Gianluca , Ronchi Dario , Pittaro Alessandra , Melzi Valentina , Peverelli Erika , Cribiù Fulvia Milena , Comi Giacomo Pietro , Mantovani Giovanna , Fonzo Alessio Di 
Published: November 2022

Abstract
Background
Allgrove disease is a rare genetic syndrome characterized by adrenal insufficiency, alacrimia, achalasia and complex neurological involvement. Allgrove disease is due to recessive mutations in the AAAS gene, which encodes for the nucleoporin Aladin, implicated in the nucleocytoplasmic transport. The adrenal insufficiency has been suggested to rely on adrenal gland-ACTH resistance. However, the link between the molecular pathology affecting the nucleoporin Aladin and the glucocorticoid deficiency is still unknown.
Results
By analyzing postmortem patient’s adrenal gland, we identified a downregulation of Aladin transcript and protein. We found a downregulation of Scavenger receptor class B-1 (SCARB1), a key component of the steroidogenic pathway, and SCARB1 regulatory miRNAs (mir125a, mir455) in patient’s tissues. With the hypothesis of an impairment in the nucleocytoplasmic transport of the SCARB1 transcription enhancer cyclic AMP-dependent protein kinase (PKA), we detected a reduction of nuclear Phospho-PKA and a cytoplasmic mislocalization in patient’s samples.
Conclusions
These results shed a light on the possible mechanisms linking ACTH resistance, SCARB1 impairment, and defective nucleocytoplasmic transport.
Combination of contrast-enhanced ultrasound and serum CA125 to differentiate benign and malignant epithelial ovarian tumors
Authors: Liang Jingqing , lv Mingyi , Zhang Dingding , Liu Sufen , Shi Yanyun , Jia zhongzhi 
Published: November 2022

Abstract
Objective
To investigate the value of the combination of contrast-enhanced ultrasound (CEUS) and cancer antigen (CA) 125 in differentiating benign and malignant epithelial ovarian tumors (EOTs).
Methods
The study was performed in patients with pathology confirmed EOTs between June 2020 and April 2022 who underwent CEUS and serum CA125 measurements. The CEUS qualitative and quantitative features were evaluated. The accuracy of CEUS combined with CA125 for determining malignant and benign EOTs was analyzed.
Results
A total of 57 patients (mean age, 46.7 ± 14.2 years, 20 malignant EOTs and 37 benign EOTs) were included in the study. The sensitivity, specificity, positive and negative predictive values of CEUS for differentiating malignant EOTs from benign EOTs were 80.0%, 86.5%, 76.2% and 88.9%, respectively; those of CA125 were 70.0%, 62.2%, 50.0% and 79.3%, respectively. In addition, the sensitivity and specificity of CEUS combined with serum CA125 were 90.0% and 94.6%, which were significantly higher than those of CEUS (χ² = 8.889, 5.185, p = 0.003, 0.023) or serum CA125 alone (χ²=13.531, 4.405, p = 0.000, 0.036). The positive and negative predictive values of CEUS with serum CA125 in differentiating benign and malignant EOTs were also significantly higher than serum CA125 alone (χ²= 7.619, 4.163, p = 0.006, 0.041), but not significantly different (χ²=1.558, 0.725, p = 0.212, 0.394).
Conclusion
CEUS combined with serum CA125 can significantly improve the differential efficiency of benign and malignant EOTs.
Model selection for component network meta-analysis in connected and disconnected networks: a simulation study
Authors: Petropoulou Maria , Rücker Gerta , Weibel Stephanie , Kranke Peter , Schwarzer Guido 
Published: November 2022

Abstract
Background Network meta-analysis (NMA) allows to estimate and rank the effects of several interventions for a clinical condition. Component network meta-analysis (CNMA) is an extension of NMA which considers the individual components of multicomponent interventions. CNMA allows to "reconnect" a disconnected network with common components in subnetworks. An additive CNMA assumes that component effects are additive. This assumption can be relaxed by including interaction terms in the CNMA.
Methods We evaluate a forward model selection strategy for component network meta-analysis to relax the additivity assumption that can be used in connected or disconnected networks. In addition, we describe a procedure to create disconnected networks in order to evaluate the properties of the model selection in connected and disconnected networks. We apply the methods to simulated data and a Cochrane review on interventions for postoperative nausea and vomiting in adults after general anaesthesia. Model performance is compared using average mean squared errors and coverage probabilities.
Results CNMA models provide good performance for connected networks and can be an alternative to standard NMA if additivity holds. For disconnected networks, we recommend to use additive CNMA only if strong clinical arguments for additivity exist.
Conclusions CNMA methods are feasible for connected networks but questionable for disconnected networks.
Does vestibular motion perception correlate with axonal pathways stimulated by STN DBS in Parkinson's disease?
Authors: Beylergil Sinem Balta , Noecker Angela M. , Kilbane Camilla , McIntyre Cameron C. , Shaikh Aasef G. 
Published: November 2022

Abstract
Perception of our linear motion – heading – is critical for postural control, gait, and locomotion, and it is impaired in Parkinson’s Disease (PD). Deep brain stimulation (DBS) has variable effects on vestibular heading perception, depending on the location of the electrodes within the subthalamic nucleus (STN). Here, we aimed to find the anatomical correlates of heading perception in PD. 14 PD participants with bilateral STN DBS participated in a two-alternative forced-choice discrimination experiment where a motion platform delivered translational forward movements with a heading angle varying between 0 and 30 degrees to the left or to the right (with respect to the straight-ahead direction). Using psychometric curves, we derived the heading discrimination threshold angle of each patient from the response data. We also created patient-specific DBS models and calculated the percentages of stimulated axonal pathways that are anatomically adjacent to the STN and known to play a major role in vestibular information processing. We performed correlation analyses to investigate the extent of these white matter tracts’ involvement in heading perception. Significant positive correlations were identified between improved heading discrimination for rightward heading and the percentage of activated streamlines of the contralateral hyperdirect, pallido-subthalamic, and subthalamo-pallidal pathways. The hyperdirect pathways is thought to provide top-down control over STN connections to the cerebellum. In addition, STN may also antidromically activate collaterals of hyperdirect pathway that projects to the precerebellar pontine nuclei. In select cases there was strong activation of the cerebello-thalamic projections, but it was not consistently present in all participants. Large volumetric overlap between the volume of tissue activation and the STN in the left hemisphere positively impacted rightward heading perception. Altogether, the results suggest heavy involvement of basal ganglia cerebellar network in STN induced modulation of vestibular heading perception in PD.
Health-promoting work schedules in nurses and nurse assistants. Results from the nationwide AMADEUS survey
Authors: FOND Guillaume , lucas guillaume , boyer laurent 
Published: November 2022

Abstract
Aim. To determine which long schedules are associated with the better self-reported work conditions and health risky behaviors in Healthcare workers (HCWs). Background. HCWs can work with 7-hour, 5 days/weeks or with long work schedules (ten to 12-hour, 3days/week). Methods. A survey was sent to public and private national healthcare facilities. The method followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement guidelines. Work environment was measured using the Job Content Questionnaire and Burnout using the French version of the 22-item Maslach Burnout Inventory (MBI) scale. Results. 3133 HCWs were recruited: 2369(75.6%) nurses and 764(24.4%) nurse assistants, of those 1811 (57.8%) (1366 nurses and 445 nurse assistants) had a 7-hour schedule and 1322 (42.2%) (1003 nurses and 319 nurse assistants) had a long work schedule. In multivariate analyses, HCWs working with a long schedule reported significantly higher rates of High psychological demand, Burnout, number of daily smoked cigarettes, coffee consumption and reported more frequently sleeping less than 5 hours/night independently of working in public sector, Hospital (vs. medico-social facility), having a full-time job, constant schedules, planned schedules, night shift job, working in medical specialty/psychiatry/critical care department, age, being partnered or having children at home. Conclusions. Some HCWs may prefer long schedules to get more resting days. However, nurses and nurse assistants working with these schedules report higher burden of work conditions and worse health risky behaviors aiming at counteracting this burden. Implications for Nursing Management. Health-promoting work schedules should be taken into account to improve high psychological demand and burnout in HCWs with long schedules.
Identifying predictors of employee silence about patient safety based on environmental factors among nurses in Ardabil:A Cross-Sectional Study
Authors: Hashemian Maryam , Aghamohammadi Masoumeh , Iranpour Sohrab , Soola Aghil Habibi 
Published: November 2022

Abstract
Background
Nurses can detect situations that threaten patient safety by providing direct care to patients. But sometimes, instead of speaking about it, they remain silent, which can harm patients. Examining the causes of silence has become a challenge in the nursing profession. Factors related to the work environment influence silence about patient safety, but how it is not fully understood. This study was conducted to investigate the predictors of employees' silence regarding patient safety based on environmental factors among nurses in Ardabil city.
Methodology
This research was descriptive and analytical, conducted cross-sectionally among 630 nurses working in five medical training centers in Ardabil, northwest Iran. This study used employee silence about patient safety questionnaire, Practice Environment Scale of the Nursing Work Index (PES-NWI), psychological safety, leader-member exchanges (LMX), and Professional discrimination experienced by nurses. Descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient, and hierarchical regression analysis were used by SPSS 16.0 software.
Results
The average score of employee silence about patient safety was (2.62 ± 0.98). Nurse participation in hospital affairs (ß= 0.196, p = 0.002), nurse's role in the quality of care (ß= -0.352, p < 0.001), staff and facility adequacy (ß= 0.156, p = 0.001), communication with the physician (ß=-0.105, p = 0.015), LMX (ß=-0.284, p < 0.001) and job position (ß=-0.093, p = 0.018) were significant predictors of employees' silence about patient safety.
Conclusion
According to the findings, the participation of nurses as much as possible in decisions and matters related to the hospital, improving the relationship between physicians and nurses, providing sufficient resources and staff, proper communication between nursing leaders and staff, and also providing suitable conditions for providing quality and safe care, are necessary to reduce the amount of silence about patient safety.
The effect of different building orientations and different filling patterns on the mechanical properties and building time of PLA using FDM technology
Authors: Ahmed Mohamed Hamoud , Abdelmonam Hussein Mohamed 
Published: November 2022

Abstract
Fused Deposition Modeling (FDM) is a Layered Manufacturing (LM) process in which progressive 2D layers of material are kept making a 3D part. To optimize the building operation, investigation is necessary to study the effect of process parameters. This study examines the impact of three filling patterns “Triangles”, “Cross” and “Cross 3D” with three filling densities (25%, 50%, and 75%) in three orientations (“Flat”, “on long edge”, and “on short edge”) on Ultimate Tensile Strength (UTS), hardness and the printing time of Polylactic Acid (PLA) material. In this work, tensile specimens were built according to ASTM D638 on an open-source 3D printer. The UTS were collected using WDW-2000 computer control electronic universal testing machine. Also, the hardiness value was measured using shore A hardness durometers DIN 53505 and ASTEM D2240. In addition, the building time was conducted by implementing “Cura 4.6.” slicer software. The results show that the filling pattern, orientation, and density, at which the part is built, have a significant effect on the strength, hardness, and building time of the part. for light structure parts 25% density, it is recommended to build part with “Triangles” “on long edge” to obtain the highest strength (31.02MPa) which improved by 74.3%, with (281HV) at min. time (1hr:10min) which reduced by 46.1%. For dense structure parts, “Triangles”, “on long edge” are recommended to give the highest strength (42.12MPa), which be improved by 69.8%, (282HV) at min. time (1hr:35min) which reduced by 36.2%. For medium construction 50% the parts can be built by the following parameters “Cross”, “on long edge” to obtain the highest strength (38.48MPa) with (283HV) at min. possible time (1hr:55min).
Symptoms of severe periodontitis are associated with lung function decline and chronic obstructive pulmonary disease in the Chinese population
Authors: Liu Zhiqiang , Zhou Xuan , Liang Lirong , Han Xiaozhe , Yang Ting , Huang Kewu , Lin Yingxiang , Wang Zuomin , Wang Chen 
Published: November 2022

Abstract
Background

The associations between periodontitis and post-bronchodilator lung function decline and chronic obstructive pulmonary disease (COPD) are not clear. We aimed to determine the associations between symptoms of severe periodontitis and pre- and post-bronchodilator lung function decline and COPD in the Chinese population.

Methods

A cross-sectional study was conducted in a large Chinese nationally representative sample of 49,202 participants aged 20–89 years. Data on demographic characteristics, symptoms of severe periodontitis included tooth mobility and natural tooth loss, frequency of tooth brushing and other information were collected. Pre- and post-bronchodilator lung function data were also collected.

Results

Symptoms of severe periodontitis were significantly associated with pre- and post- bronchodilator lung function variables decline in the multivariable adjusted multiple linear regression models (all p < 0.001), and were also associated with pre- and post-forced expiratory volume in 1 second (FEV1) / forced vital capacity (FVC) < 0.7 (odds ratios (OR) = 1.11, 95% confidence interval (CI) 1.05–1.19, p = 0.001 and OR = 1.08, 95%CI 1.01–1.16, p = 0.03) in the multivariable adjusted multiple logistic regression models. Never brush tooth is associated with pre- and post-FEV1/FVC decline and pre- and post-FEV1/FVC < 0.7 in the multivariable adjusted multiple regression models (all p < 0.01).

Conclusions

Our data suggest that symptoms of severe periodontitis included tooth mobility and natural tooth loss are both associated with pre- and post-bronchodilator lung function decline and COPD (post-FEV1/FVC < 0.7) in the Chinese population.