bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of Laurence Moon Bardet Biedl syndrome
Authors: Kaluvai Sai Indraneel , K. V. Rajalakshmi , P. K. Anantha Kumar , N. Bubhaneshwar 
Published: December 2022

Laurence Moon Bardet Biedl syndrome (LMBBS) is a rare autosomal recessive disorder characterized by retinitis pigmentosa, obesity, hypogonadism, mental retardation and polydactyly. We present a case of 20-year-old male with history of intellectual delay, speech impairment and progressive vision loss. Presented with chief complaints of Breathlessness, oliguria, abdominal distension. Upon examination he is morbidly obese, short stature, pedal edema, facial puffiness, polydactyly of feet, micro penis and retinitis pigmentosa. He presented with primary pentad features of LMBBS with CKD stage 5 for which he was started on hemodialysis. He also had secondary features of speech delay, developmental delay, dental crowding, high arched palate and ventricular hypertrophy. Management of LMBBS is supportive. genetic counselling of affected families raises awareness about need to get the other family members assessed for renal and cardiovascular problems.
Clinical outcome of proximal tibia plates in extra-articular proximal tibia fractures: a retrospective study
Authors: Sharma Akash , Jain Arpit , Luthra Gaurav 
Published: December 2022

<p><strong>Background:</strong> Tibial fractures, which account for 2.2% of all intra-articular fractures, are frequent. These fractures are prevalent in two age groups: younger patients experience higher-energy fractures, whereas elderly patients experience lower-energy fractures as a result of osteopenia. These injuries are linked to a higher frequency of complications such as non-union, infection, mobility limitation, and post-traumatic arthritis in the younger population. The study's primary objective was to assess the results of proximal tibial fracture treated with a locking plate.</p><p><strong>Methods:</strong> Thirty patients with proximal tibia fractures are included in this retrospective clinical study. They are all treated with a tibia plate system made by Kaulmed private limited in Sonipat, Haryana, India. Thirty patients consisting of 18 males and 12 females, with average age of 42 years. Fractures categorized based on AO classification and type of soft tissue injury. Patients assessed clinically, radiologically, functionally using VAS, post-op radiographs and ROM.</p><p><strong>Results:</strong> All 30 cases that were chosen were monitored for 6 months. The average time for fracture union was 21 weeks, with a range of 18 to 24 weeks. No delayed union and non-union was observed. Infection, valgus, Knee stiffness were the complication that was observed. Two patients complained about the mild pain on the post-operative visit. Acceptable knee ROM of angle &gt;120° was achieved and all patients were satisfied at their last visit based on parameters of pain, ADLs, aesthetics and full weight bearing.</p><p><strong>Conclusions:</strong> Excellent results were achieved in the surgical treatment of proximal tibia fractures by MIPO (minimal invasive plate osteosynthesis) and ORIF (Open reduction and internal fixation) using proximal tibia plate technique. Optimum knee function is achieved with reduction, rigid fixation to restore articular fragments, and early mobility. preventing osteoarthritis following trauma.</p>
Seroprevalence of Bovine Viral Diarrhea Virus and Factors Associated with the Serological Status in Dairy Cattle in Western Region of Thailand
Authors: Thongtem Niramol , Lertwatcharasarakul Preeda , Yatbantoong Nantawan , Arunvipas Pipat 
Published: December 2022

Background: Bovine viral diarrhea virus (BVDV) causes productive losses and reproductive failure in dairy farms. This study defined the seroprevalence and determined the factors associated with BVDV infection in dairy cows in the western region of Thailand. Methods: Blood samples were collected from 732 cows in 30 randomly selected dairy herds. The BVDV antibody was detected using a commercial indirect ELISA kit (IDEXX®BVDV Total Ab, IDEXX Laboratories Inc., Maine, USA). A questionnaire about the herd management was used to collect data via interviews with farm owners. The variables identified by Fisher’s Exact Test (p less than 0.20) were then analyzed using multivariate logistic regression. Result: Individual prevalence of BVDV infection was 36.89% (270/732), while herd prevalence was 93.33% (28/30). Significant risk factors of BVDV based on the univariate analysis were identified as area, herd size, feeding type, history of abortion, pen of calving, biosecurity and pet on farm (p less than 0.05). Biosecurity using no disinfectant (p=0.02) (OR, 1.32; CI 95%, 1.038-1.669), pet on farm (p=0.03) (OR, 4.72; CI 95%, 1.142-19.501) and history of abortion (p=0.00) (OR, 0.02; CI 95%, 0.004-0.140) were significant, based on multivariate regression analysis. Pen of calving (p=0.01) (OR, 0.24; CI 95%, 0.084-0.667) was a protective factor for BVDV infection. BVDV infection in dairy cattle herds was distributed throughout the western region of Thailand.
Pelibatan Private Military Company dalam Misi Perdamaian di Afganistan oleh PBB di Tahun 2014
Authors: Prasetyo Cahyo Tri , Albayumi Fuat , Hara Abubakar Eby 
Published: December 2022

The level of security in Afghanistan has started to deteriorate since American military activities began. This is because the fight between the United States and the Taliban organization is causing an increasing number of civilian deaths. The United Nations (UN) is now involved in settling the conflict in Afghanistan as a result of the escalating conflict conditions there. In addition to deploying troops from member nation contingents, the UN also enlists the aid of a Private Military Company (PMC) to help carry out the peace mission in Afghanistan. However, International organization role theory and rational choice theory are both used in this Article.
Keyword : UN, PMC, Afganistan
Capacity Building of Society Affected By Floods Through Local Volunteer Community In Dringu Village Probolinggo City
Authors: Wahyuni Hayu , Suhartini Elly , Arifiyanti Jati 
Published: December 2022

Dringu Village is a village that floods often occur that is every rainy season. In 2021 Dringu Village experienced a servere flash flood disaster that had many impacts on the Dringu Village community. After the flood disaster, the people of Dringu Village formed a “komunitas relawan lokal” to be able to help each other. This local volunteer community was formed by the concerned of the community affected by the flood disaster. Those who join the “komunitas relawan lokal” are people affected by the flash flood disaster and the community of women. Community participation in disaster management can create a development of community capacity in facing flood disasters. This research uses a qualitative method, analyzed uses theory of communicative action by Jurgen Habermas.
Keywords: dringu village; komunitas relawan lokal; flood; capacity
Correlation between Corona Viruses Disease (Covid-19) and C-Reactive Protein (CRP) in Patients at Haji Hospital Surabaya
Authors: Saputro Tri Ade , Purwaningsih Nur Vita , Ainutajriani Ainutajriani , Watoyani Tony 
Published: December 2022

Coronavirus Disease (Covid-19) is a new type of virus that has never been previously identified in humans. Common signs and symptoms of Covid-19 infection include symptoms of acute respiratory distress such as fever, cough and shortness of breath. C-Reactive Protein (CRP) is a protein in serum that causes inflammation in the body. The presence of this inflammatory response causes the levels of CRP in the body to increase significantly. To determine the severity of Covid-19 disease, one of the screening tests used is the CRP examination, starting when clinical symptoms appear, becoming high levels of CRP indicating inflammation or inflammation. This study aims to determine CRP levels in patients who were confirmed positive for Covid-19 at RSU Haji Surabaya. The research method used is descriptive research with secondary data. The sample in the study was 60 patients who had confirmed Covid-19 and performed a CRP test from February to June 2021. The sampling technique used a total sampling technique at the Haji General Hospital Surabaya. The results showed that from 60 confirmed Covid-19 inpatients, 58 patients (96.6%) had CRP levels with high risk criteria or CRP levels > 5 mg/L and 2 patients (3.4%) had CRP levels. with normal criteria or CRP levels < 5 mg/L. Based on the results, it can be concluded that CRP levels are positively correlated with the development and severity of Covid-19 disease.
Seismic resilience assessment: a case study
Authors: Sediqi Zubair , Harmandar Ebru 
Published: December 2022

Abstract

The aim of the seismic resilience of a structural system is to prevent, minimize or decrease the damages (loss of life, social, economic, structural, and non-structural damages) that occur due to earthquakes. The seismic resilience of structures is one of the most interesting topics in the earthquake and structural engineering. The meaning of the word 'resilience' differs from field to field, but in earthquake and structural engineering, resilience means returning the functionality of a structural system after it has been damaged. A seismic resilience study for a school building in Milas, Mugla which is one of the most hazardous areas in Turkey is performed. The present study deals with pushover analysis, fragility curves, vulnerability curves, and functionality curves to evaluate the seismic resilience of the mentioned school. The damage assessment methodology is done based on HAZUS MH MR4 (2003). SAP2000 software is used for the modeling of the building. Nonlinear pushover analysis is performed. This study will help bring improvements in the seismic resilience of school buildings and it will be a base input for the resilience of other school buildings as well.
METTL3-m6A methylation inhibits Type II Alveolar Epithelial Cells proliferation and viability by promoting PTEN mRNA stability and translation efficiency in the acute lung injury
Authors: Zhuang Lei , Wang Qiuyun , Shen Jie , Luo Shiyuan , Yuan Zhize , Li Qiang , Yang Qianzi , Luo Yan 
Published: December 2022

Abstract
Acute lung injury (ALI) is a life-threatening acute inflammatory disease with high morbidity and mortality rates. N6-methylation of adenosine (m6A) is an abundant mRNA nucleotide modification, which is critical for mRNA metabolism and function. However, the role of m6A modifications in ALI progression remains unclear. To address this problem, we modeled ALI in vivo by intraperitoneally injecting lipopolysaccharide (LPS) to C57BL/6 mice. In addition, we isolated alveolar type II cells (AECII) from the lungs of C57BL/6 mice and treated them in vitro with various concentrations of LPS. An m6A RNA methylation quantification kit was used to detect methylation levels. An m6A microarray and mRNA transcriptomic sequencing were used to screen the downstream targets of methyltransferase-like 3 (METTL3)-mediated m6A modifications. Gene and protein expression levels were determined by qRT-PCR and western blotting. The biological effects of modulating METTL3 expression level were evaluated both in vitro and in vivo. The binding between proteins and mRNA was verified by the RNA immunoprecipitation assay. The CCK-8 and EdU assays were used to examine changes in AECII viability and proliferation. The global number of mRNA m6A-modified loci and the “writer” methyltransferase METTL3 expression were significantly increased in the lung tissue following ALI and in LPS-treated AECII. METTL3 knockdown reduced the viability and proliferation of LPS-treated AECII. Furthermore, METTL3-mediated m6A modification of phosphatase and tensin homolog (Pten) mRNA enhanced its stability. Collectively, our results showed that METTL3 contributes to ALI progression by increasing stability and translation efficiency of Pten mRNA by means of m6A modification, indicating that METTL3 might become a new and innovative therapeutic target for the treatment of ALI.
The effect of the socio-economic status on the investigation time of patients with lung cancer a register based cohort-study
Authors: Iachina Maria , Anru Pavithra Laxsen , Jakobsen Erik 
Published: December 2022

Abstract
Background
The purpose of this nationwide population-based study is to investigate whether the time length of the primary investigation for lung cancer is longer for patients with a low socio-economic position than for patients with a high socio-economic position.
Materials and Methods
This retrospective register study was based on all lung cancer patients in Denmark who were diagnosed in 2012–2017, in total 28,431 patients. We used an adjusted logistic regression model and adjusted zero-inflated negative binomial model to estimate the effect of vulnerable socio economic factors on the time length of the primary investigation.
Results
We found that patients’ income and difficulty of transport have a significant influence on time length of the primary investigation. The chance to carry out the investigation process within 24 days is higher for patients with a high income (adjusted OR = 0.86 with 95% CI (0.81; 0.91)), whereas the chance to carry out the investigation process within 24 days for patients with troublesome transport is lower (adjusted OR = 0.67 with 95% CI (0.61; 0.72)).
Conclusion
Our study showed that the individual socio-economic position has an influence on the time length of the primary lung cancer investigation.
Pakistan Flood of 2022: Assessment using suite of satellite sensors and hydrological modelling
Authors: Gupta Praveen Kumar , Dubey Amit Kumar , Pradhan Rohit , Chander Sharad , Singh Nimisha , Jha Vibhuti Bhushan , Gujrati Ashwin , Wadhwa Chirag , Desai Nilesh M 
Published: December 2022

AbstractFloods are one of the most common natural disasters. In recent decades, climate change has increased the occurrence and severity of floods, which is exacerbated by population growth. Pakistan witnessed one of its most devastating floods during monsoon of 2022. In the present study, spatio-temporal characteristics of 2022 floods in the Indus river basin has been studied using an integrated framework of multi-satellite observations and hydrological modelling. Satellite sensors including Synthetic Aperture Radar (SAR), passive microwave radiometer, radar altimeters, optical sensors, gravity measurements etc. have been used to assess the extent of flood and retrieve various hydrological parameters. Multi-year river discharge simulation was performed using Weather Research and Forecasting (WRF)-Hydro model to analyse peak flood discharges in the Indus river system. Inter-comparison of hydrological variables viz. river and lake water levels, flood index & discharge obtained from remote sensing platforms and model simulation were performed. Passive microwave radiometer effectively captured the incidence, progression and persistence of flood owing to its high temporal resolution. Altimeters provided precise information on river and lake water levels in the Indus basin and high spatial-resolution SAR data (Sentinel-1A) provided information on areal flood extent, which was used to compute water depth and estimate water volume. Model simulated discharge of Indus River and its tributaries correlated well with the satellite-observed water level and mean flood index. This paper demonstrates the use of available satellite sensors for effective assessment and modelling of floods, which may prove useful for mitigating future flood events.
Proactive review for people with diabetes in hospital: a cluster randomised feasibility trial with process evaluation protocol
Authors: Lake Andrea Kathleen , Bansiya Vishakha , Davenport Katy , Murdoch Jamie , Murphy Helen R , Smith Toby , Clark Allan , Arthur Antony 
Published: December 2022

Abstract

Background: Inpatient diabetes management is sub-optimal as demonstrated in successive National Diabetes Inpatient Audits. Diabetes inpatient specialist services vary across the country, with limited evidence to guide service delivery. Currently referrals in hospitals to diabetes specialists are usually ‘reactive’ after diabetes related events, such as hypoglycaemia and hyperglycaemia, both of which are associated with increased risk of morbidity/mortality and increased length of hospital stay.
Method: We will conduct a cluster randomised feasibility study with process evaluation. The Proactive Diabetes Review Model (PDRM) is a complex intervention that aims to minimise rather than respond to potentially modifiable diabetes related harms by pre-empting them. The PDRM differs from usual care in its focus on early prevention. All eligible patients will be reviewed by a diabetes inpatient specialist nurse within one working day of admission.
Trial duration will be approximately 32-weeks. Eight wards will be randomised to either PDRM or usual care. Adult patients with a known diagnosis of diabetes admitted to an included ward will be eligible. Data collection will be limited to that typically collected as part of usual care. Data collected will include descriptive data at both the ward and patient level and glucose measures, such as frequency and results of capillary glucose testing, ketonaemia and hypoglycaemic events. Analysis aims to determine the feasibility of both the intervention and a future definitive trial. A qualitative process evaluation will be conducted in parallel to the trial. A minimum of 22 patients, nurses, doctors, and managers will be recruited with methods including direct non-participant observation and semi-structured interviews. The feasibility of a future definitive trial will be assessed by evaluating recruitment and randomisation processes, staffing resources, and quality of available data.
Discussion: The aim of this cluster randomised feasibility trial with a process evaluation is to explore the feasibility of a definitive trial and identify appropriate outcome measures. If a trial is feasible and the effectiveness of PDRM can be evaluated, this could inform the future development of inpatient diabetes services nationally.
Trial registration: UK Clinical Research Network: 51167; ISRCTN, ISRCTN70402110. Registered 21/02/2022, https://www.isrctn.com/ISRCTN70402110?q=ISRCTN70402110&filters=&sort=&offset=1&totalResults=1&page=1&pageSize=10
Pleiotropic effect of Ppd-D1a on earliness, yield and yield components of bread wheat under well-watered and rain-fed conditions
Authors: Pourtabrizi Soraya , Mohamadi-Nejad Ghasem , Khajoei-Nejad Gholamreza , Abdolshahi Roohollah 
Published: December 2022

Abstract
Early heading is a very important character for bread wheat cultivated under end season heat and drought stress conditions. Heading time is influence by three groups of genes including photoperiod (Ppd), vernalization (Vrn) and earliness per se (Eps). Among the identified genes for heading time, Ppd- D1 is the only gene that worth marker assisted selection/backcrossing. Despite of recognized effect of Ppd-D1a on earliness, its effect on yield, yield component and important agronomic traits is under debate. In the present research, near isogenic lines were developed for Ppd-D1a in two genetic backgrounds, Roshan and Kalheydari, to investigate the precise pleiotropic effect of Ppd-D1a on yield and yield components of bread wheat. Two pairs of isogenic lines were assessed under rain-fed and well-watered conditions in Kerman and Sepidan during two successive growing seasons, 2020–2021 and 2021–2022. Compared to photoperiod sensitive allele (Ppd-D1b), photoperiod insensitive allele (Ppd-D1a) reduced days to heading and ripening by 5.14 and 7.53 days, respectively. Results also showed that Ppd-D1a improved 1000-grain weight (+ 17%) and decreased grains number per spike (-14%) to finally improve grain yield under rain-fed conditions (+ 13%). However, Ppd-D1a had a different effect on the mentioned traits under well-watered conditions where decreased 1000-grain weight (-18%) and improved grains number per spike (+ 10%) with insignificant effect on grain yield. These findings showed that pleotropic effect of Ppd-D1a on yield and yield component strongly depends on target environment.
Potential prognostic gene FCGR2A in cutaneous melanoma associated with the immune infiltration of neutrophils
Authors: Gong Jin , Wang Xianmo , Lu Changyu , Huang Faqing , Zhao Yan 
Published: December 2022

Abstract
Objective
To investigate the relationship between potential prognostic genes and immune infiltration in cutaneous melanoma, and to provide methods and ideas for the clinical treatment of cutaneous melanoma.
Methods
Consensus clustering analysis of cutaneous melanoma dataset was performed using the R software ConsensusClusterPlus package; immune score and checkpoint analyses of the grouped genes were performed using the TIMER algorithm in the immunedeconv package, and a potential immunotherapeutic response was predicted using the TIDE algorithm. The two groups of samples were analyzed using the R software Limma package’s differential expression analysis to obtain differential genes, and the intersection of differential genes and immune-related genes was determined to select overlapping partial genes. The STRING database was used to perform a PPI analysis of the intersecting genes to obtain the protein interaction network, and the MCODE plug-in allowed for the highest scoring module to be obtained. A LASSO analysis was used to determine the genes with prognostic features, and univariate cox and multivariate cox analyses revealed the independent prognostic genes associated with cutaneous melanoma. TIMER was used to analyze the correlation of independent prognostic genes with immune-related cells in relation to survival.
Results
The cutaneous melanoma dataset was divided into two subgroups, G1 and G2, with higher immune scores and checkpoint expression in G2 than in G1. DEG obtained 67 up-regulated genes and 772 down-regulated genes, with a total of 615 genes overlapping with immune-related genes. The largest module contained 82 genes after the PPI analysis, and the LASSO analysis yielded nine melanoma prognosis-associated genes. Univariate cox and multivariate cox analyses yielded FCGR2A as an independent prognostic factor for melanoma, and FCGR2A correlated strongly with neutrophils.
Conclusion
FCGR2A can be considered a potential prognostic key gene in cutaneous melanoma and is strongly correlated with neutrophil immune infiltration.