bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can toothpastes protect dentin against erosive tooth wear and dentin hypersensitivity at same time? An in vitro study
Authors: Lopes Raquel Marianna , Maia Mariana Beraldo , Maximiano Vinícius , Yoshida Mirian Lumi , Grandizoli Diana Roberta Pereira , Cabral Camila Cardoso , Aranha Ana Cecília Corrêa 
Published: June 2022

Abstract
Objectives: To evaluate different desensitizing and anti-erosive toothpastes on dentin surface loss (SL) and the number of open dentin tubules (ODT).Methods: The 10 groups (n=10) were: 1. Distilled water - negative control (N), 2. Colgate Total 12 - positive control (CT); 3. Bianco Pro Clinical (BP); 4. Bianco Advanced Repair (BA), 5. Elmex Sensitive (ES), 6. Elmex Anticaries (EA), 7. Elmex Erosion (EE); 8. Sensodyne Rapid Relief (SRR); 9. Sensodyne Repair&Protect (SRP), and 10. Colgate Pro-Relief (CP). The cycling consisting of immersion in 0.3 % citric acid (5 min) and artificial saliva (60 min), 4×/day; 5 days. Toothbrushing was performed 2x/day (45 strokes). The SL was determined using an optical profilometer. All toothpastes had their pH evaluated. The specimens were also analyzed using a scanning electron microscope (SEM) to verify the ODT, and energy dispersive spectrometry (EDS). Results: EA showed the lowest SL (p < 0.05), but not differing from EE, SRP, BPC, SRR, ES, and BA. Only the groups EA, EE and SRP was different statistically from negative and positive control . The SEM results revealed that SRP had the lowest ODT (p = 0.004). Negative control, ES, and BP showed no difference in ODT from initial condition (p > 0.005). There was a weak positive correlation between SL and ODT and SL with pH, and a negative correlation was observed between ODT and pH (all p > 0.05). Conclusion: SRP, EE, and EA decreased SL; only SRP decreased the number of ODT Clinical Significance: Some toothpastes may be more suitable for preventing only erosive tooth wear such as Elmex Erosion, Elmex Anti Caries and Sensodyne Repair and Protect, and the latter may be indicated for tubular occlusion as well. In addition, as Sensodyne Repair and Protect offers interesting results for both situations, can be indicated for patients with both conditions in the oral environment: erosive tooth wear and dentin hypersensitivity.
Adsorption performance and optimization by response surface methodology on tetracycline using Fe-doped ZIF-8 loaded with multi-walled carbon nanotubes
Authors: Li Jiacheng , Tian Tian , Jia Yannan , Xu Nannan , Yang Shujun , Zhang Chenyue , Gao Shiwei , Shen Wei , wang zheng 
Published: June 2022

Abstract
A metal-organic framework material, an iron-doped ZIF-8 loaded with multi-walled carbon nanotubes (FZM), was fabricated and used to adsorb tetracycline (TC) in this investigation. The adsorption impact and mechanism of TC on FZM were revealed using batch adsorption experiments and characterization analyses. The effects of Fe doping amount, pH, temperature, beginning concentration, and coexisting ions on the adsorption effect of TC were explored. It was discovered that Fe doping amount of 75 mg, pH of 6, and initial concentration of 100 mg/L produced the optimum adsorption effect. TC adsorption was also enhanced by the presence of Ca2+. The adsorption process of TC on FZM followed the pseudo-second-order (PSO) kinetic and Freundlich isotherm models, indicating that chemisorption was the dominant factor in the removal process of TC and the reaction was multilayer adsorption, with a theoretical maximum saturation capacity of 1111.11 mg/g fitted according to the Langmuir model, which was better than most other adsorbents. The procedure of TC adsorption on FZM. The adsorption process on FZM is a spontaneous, heat-absorbing process, and the adsorption capacity increases as the temperature rises. According to the findings of the FTIR study undertaken before and after adsorption, the mechanism of TC on FZM is predominantly intermolecular hydrogen bonding, surface complexation, π-π interactions, and electrostatic interactions. The projected adsorption capacity of TC was 599.78 mg/g under optimal adsorption circumstances of pH 7.1, temperature 312.5 K, and injection amount 64.43 mg/L, with a divergence of 1.73 % from the actual value, according to the response surface optimization studies. Furthermore, FZM has high reusability, and after four cycles of trials, the adsorption capacity of TC on FZM may still be greater than 370 mg/g, with a 15% loss. The cost of treating 100 mg/L of TC effluent was estimated to be around 8.35 US$/m3, indicating that FZM had excellent application possibilities for TC removal.
Development and interpretation of a clinicopathological-based model for the identification of microsatellite instability in Colorectal Cancer
Authors: Jiang Zhenxing , Cao Yinghao , Yan Lizhao , Deng Shenghe , Gu Junnan , Qin Le , Mao Fuwei , Xue Yifan , Cai Wentai , Nie Xiu , Liu Hongli , Shang Fumei , Cai Kailin , Tao Kaixiong , Wang Jiliang , Wu Ke 
Published: June 2022

Abstract
Background:Chemotherapy is not recommended for patients with deficient mismatch repair(dMMR)in colorectal cancer(CRC), so assessing the status of MMR is crucial for the selection of subsequent treatment. Therefore, this study aims to build predictive models to accurately and rapidly identify dMMR.Methods:A retrospective analysis based on the clinicopathological data of patients with colorectal cancer from May 2017 to December 2019 at Wuhan Union Hospital was performed. The variables were subjected to co-linearity analysis, least absolute shrinkage and selection operator (LASSO) regression and random forest (RF) feature screening. Four sets of machine learning models (i.e., extreme gradient boosting (XGBoost), support vector machine (SVM), naive bayes (NB), and random forest and a conventional logistic regression (LR) model were built for training and testing. Receiver operating characteristic (ROC) curves are plotted to evaluate the predictive performance.Findings:A total of 2279 patients were included in the analysis and were randomly divided into a training group and a test group.The final 12 clinicopathological features were incorporated into the predictive models. The Area Under the curve (AUC) values of the five predictive models were 0.8931 in XGBoost, 0.8906 in SVM, 0.8512 in NB, 0.9088 in RF and 0.8319 in LR. The results showed that the random forest exhibited the best recognition ability and outperformed the conventional logistic regression method in identifing dMMR and proficient mismatch repair (pMMR).Conclusion:Our predictive models built on routine clinicopathological data can significantly improve the diagnostic performance of dMMR and pMMR. Meanwhile, four machine learning models outperformed conventional logistic regression model.
Muscle fiber ultrastructure is associated with the immunological profile in idiopathic inflammatory myopathies.
Authors: Aguilar-Vazquez Andrea , Chavarria-Avila Efrain , Salazar-Paramo Mario , Armendariz-Borunda Juan , Toriz-González Guillermo , Rodríguez-Baeza Marcela , Sandoval-Rodriguez Ana , Villanueva-Pérez Arisbeth , Godínez-Rubí Marisol , Medina-Preciado Jose-David , Lundberg Ingrid , Lozano-Torres Yesenia , Gomez-Rios Cynthia-Alejandra , Pizano-Martinez Oscar , Martinez-Garcia Erika-Aurora , Martin-Marquez Beatriz-Teresita , Duran-Barragan Sergio , Palacios-Zárate Brenda-Lucia , Llamas-Garcia Arcelia , Gómez-Limón Livier , Mercado Monica Vazquez-Del 
Published: June 2022

Abstract
The diagnosis and classification of Idiopathic Inflammatory Myopathies (IIM) remain complex because of the lack of information about their pathogeny. Scanning Electron Microscopy (SEM) allows a histological analysis with better resolution, which together with the immunological profile, is useful for a better understanding of physiopathology. For immunological profile characterization, we identified the presence of autoantibodies (Ro-52, OJ, EJ, PL7, PL12, SRP, Jo-1, PMScl75, PMScl100, Ku, SAE1, NXP2, MDA5, TIF1γ, Mi-2α, Mi-2β) and quantified cytokines (IL-1β, IFN-α2, IFN-γ, TNF-α, IL-6, IL-10, IL-12p70, IL-17A, IL-18, IL-23, IL-33) and chemokines (CCL2, CXCL8). The histological analysis was made by hematoxylin-eosin staining while the muscle fiber was characterized by SEM. We observed changes in the morphology and structure of the muscle fiber according to muscle strength and muscle enzymes. We were able to find and describe muscle fiber ultrastructure with marked irregularities, porosities, disruption in the linearity and integrity of the fascicle, more evident in patients with increased serum levels of muscle enzymes and diminished muscle strength. Even the scarce reports about the use of SEM as a tool in all clinical phenotypes of IIM, our work provides an excellent opportunity to discuss and reframe the clinical usefulness of SEM in the diagnostic approach of IIM.
Mechanical and fatigue resistance of restorations supported by welded- framework and realized using computer-aided designed prosthetic shells: in vitro pilot study
Authors: Albiero Alberto Maria , Bevilacqua Lorenzo , Pegoraro Federica , Turco Gianluca , Momic Stefano , Lenarda Roberto Di , Maglione Michele 
Published: June 2022

Abstract
Objective Resin coating in implants rehabilitation not always can be aesthetic, durable and comfortable for the patient mainly due to the limited dimensions of the final structure. Intraoral welding technique and computer-aided designed prosthetic shells may be a solution.This in vitro study evaluates the capacity of load and the weakest point of implant-supported provisional prosthesis using welded titanium framework.Methods Twelve samples were produced to simulate an implant supported fixed prosthetic bridge. Two implants (Ankylos; Dentsply Implant Manufacturing; Germany) were inserted inside blocks of nanoceramic material produced with a stereolithographic 3D printer. A polymethylmethacrylate (PMMA) resin shell was performed with CAD/CAM and relined on welded framework. Six samples were performed with the same procedure reducing resin thickness. The samples were subjected to fatigue test (6’500’000 cycles) using ElectroForce 3310 fatigue machine (t1); subsequently a mechanical compression test using a universal Shimadzu AGS-X 10 machine (t2). The samples were analyzed with photographic and radiographic documentation at t0, t1 and t2.Results The samples survived mechanical fatigue test without evidence of failure. The radiographic and photographic evaluation revealed the fracture of resin coating after mechanical compression test. The samples with minimal resin thickness fracture first.Conclusion Adequate assessment of the resin thickness is mandatory for the improve the longevity of this rehabilitations.Clinical Relevance CAD-CAM digital prosthetic design allows us to optimize the thicknesses and the prosthetic shapes, allowing us to obtain good degrees of resistance even in the presence of reduced prosthetic spaces
Pien Tze Huang Regulates Phosphorylation of Metabolic Enzymes in Mice of Hepatocellular Carcinoma
Authors: Lin Jinxia , Wang Shicong , Lan Wenliang , Ji Ming , Li Mei 
Published: June 2022

Abstract
The Chinese medicine formula Pien Tze Huang (PZH) has been applied to the treatment of various diseases, the reported anti-tumor mechanisms included regulation of inflammation-associated cytokine secretion and cancer growth pathways. However, the potential influence of PZH on tumor metabolism remains unclear. This study aimed to investigate the global effect of PZH on hepatocellular carcinoma (HCC) compared with the anti-tumor agent sorafenib based on proteomic and phosphoproteomic analysis in addition to parallel response monitoring (PRM) verification. It was observed that PZH could inhibit tumor weight by 59%-69% in different concentrations. Proteomic studies indicated that fructose/mannose metabolism and glucagon signaling pathway in PZH group, and arachidonic acid metabolism and PPAR signaling pathway in sorafenib group, were significantly enriched, while glycolysis/gluconeogenesis pathway was found to be enriched remarkably both in PZH and sorafenib groups in phosphoproteomic study. Expressions of significant proteins/peptides in the enriched pathways were further verified by using PRM method, and the results verified that both PZH and sorafenib could down-regulate phosphorylations of the metabolic enzymes phosphofructokinases 1, fructose-bisphosphate Aldolase A, phosphoglycerate mutase 2 and lactate dehydrogenase A chain in glycolytic pathway, furthermore, phosphorylations of long chain fatty acid CoA ligase in fatty acid activation and acetyl-coenzyme A synthetase in glycolysis were obviously inhibited by PZH and sorafenib, respectively. This study proposed that PZH shared a similar anti-tumor mechanism of metabolic regulation to sorafenib, but differed in the regulation of some metabolic nodes. This is the first time to uncover the relationship between the anti-tumor effect of PZH and metabolic related enzymes, which distinguished from the known mechanisms of PZH. These data provided the potential molecular basis for PZH acting as a therapeutic drug for HCC, and offered cues of manipulation on Warburg effect under the treatment of PZH.
Assessment of Heavy Metals in Children's Blood from the Rural Region of Popokabaka, Democratic Republic of Congo: A Cross-Sectional Study and Spatial Analysis
Authors: Mbunga Branly Kilola , Gjengedal Elin L. F. , Bangelesa Freddy , Langfjord Mina M. , Bosonkie Marc M. , Strand Tor A. , Mapatano Mala Ali , Engebretsen Ingunn M. S. 
Published: June 2022

Abstract
Heavy metals affect cell differentiation, neurocognitive development, and growth during early life, even in low doses. Little is known about heavy metal exposure and its relationship with nutrition outcomes in nonmining rural environments. We carried out a community-based cross-sectional study to describe the distribution of four heavy metal concentrations [arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg)] in the serum of a representative population of children aged 12 to 59 months old from the rural region of Popokabaka, Democratic Republic of Congo. The four metals were measured in 412 samples using inductively coupled plasma–mass spectrometry (ICP–MS). Limits of detection (LoD) and limits of quantification (LoQ) were set. Percentiles were reported. Statistical and geospatial bivariate analyses were performed to identify relationships with other nutrition outcomes. Arsenic was quantified in 59.7%, while Cd, Hg, and Pb were quantified in less than 10%, all without toxicities. The arsenic level was negatively associated with the zinc level, while the Hg level was positively associated with the selenium level. This common detection of As in children of Popokabaka requires attention, and urgent drinking water exploration and intervention for the profit of the Popokabaka community should be considered.
Near field and far field plasmonic enhancements with bilayers of different dimensions AgNPs@DLC for improved current density in silicon solar
Authors: Hekmat Maryam , Shafiekhani Azizollah , Khabir Mehdi 
Published: June 2022

Abstract
The effect of a bilayer of different dimension silver nanoparticles (Ag NPs) on light trapping in silicon solar cells is investigated. Here, we report on the improved performance of silicon solar cells by integrating two layers of silver nanoparticles of different sizes. We experimentally examine the plasmonic near-field and far-field effects of bilayer Ag NPs embedded within an anti-reflective DLC layer on the optical and electrical characteristics of silicon solar cells. The two-dimensional differences in the size of Ag NPs were driven by Field-Emission Scanning Electron Microscopy. The surface plasmon resonance of the two-dimensional nanoparticles was estimated from the absorption optical spectra. External quantum efficiency measurements showed that near-field or far-field plasmonic effects altered with the Ag NPs size. The effect of far fields was confirmed by measuring the solar cell performance under AM 1.5 G illumination. The effect of the far-field in the cell containing two layers of Ag NPs, which outer layer is larger dimensions NPs, improves the current density up to 38.4 mA/cm2 (by 70% compared to the bare reference cell).
Comparison of Different Methods in Determining the Laryngeal Mask Airway (LMA) Size in Adult Patients
Authors: Şişecioğlu Yasemin Dark , Gökel Erol , Hancı Volkan , Ozbilgin Sule 
Published: June 2022

Abstract
PurposeIn this study, we aimed to compare the effects of different LMA size selection methods on successful LMA application, perioperative ventilation parameters and postoperative airway complications in determining the appropriate size of LMA used for elective surgery in adult patients in our operating room.MethodsAll data obtained from records of ASA group I-II patients between ages 18 and 70, who were anesthetized by using LMA and had elective surgery. Cases were classified according to methods used for deciding appropriate LMA size, and retrospectively successful LMA application, perioperative ventilation parameters and postoperative complications were recorded.ResultsA total of 190 patients were included in our study grouped in 5 different ways. For the 51 cases, the LMA size was chosen according to the body weight of the patients in LMA size selection guided weight according to the body weight of the manufacturer. For the thirty-three cases, the size of the LMA, approximately equal to the width of the external auditory canal auricula, was used. The size of the LMA selected for thirty-eight cases was the LMA dimensions corresponding to the language width of the cases. In thirty-six cases, the size of the LMA that corresponds to the width of the fingers, while the thumb, and the small finger were opened to the outside, and the second, third and fourth fingers were adjacent, were preferred. In thirty-two cases, it was found that the appropriate LMA was chosen to correspond to this distance by looking at the thyromental distances of the cases. The best score in terms of LMA insertion score was found out to be in Group Ear. The best group in terms of the number of attempts to place the LMA in the cases was found out as Group Ear. Group Ear was the best group for the complications of sore throat in terms of postoperative complications.ConclusionThe results of our study showed that the ear size measurement method was one of the effective methods to decide the appropriate LMA size. Therefore, it can be said that the ear size can be used as a guide for the selection of the appropriate LMA size. This method may be an addition to the methods currently in use and can save users from remembering formulas and tables based on body weight / gender.
Nonlinear dynamics of traveling beam with longitudinally varying axial tension and variable velocity under parametric and internal resonances
Authors: Raj Sanjay Kumar , Sahoo Bamadev , Nayak Alok Ranjan , Panda L. N 
Published: June 2022

Abstract
In this investigation, the nonlinear dynamics of an axially accelerating viscoelastic beam on a pully mounting system have been analyzed. The axial tension of the beam is modeled as a function of the traveling velocity, support stiffness parameter as well as spatial coordinate. Geometric cubic nonlinearity appeared in the equation of motion due to elongation set in the neutral axis of the beam. The integro-partial differential equation of motion of the axially accelerating beam associated with the simply-supported end conditions is solved analytically by adopting the direct perturbation method of multiple time scales (MMS). As a result, a set of complex variable modulation equations are generated, which governs the modulation of amplitude and phase. This set of modulated equations is numerically solved to explore the influence of the support stiffness parameter upon the stability and bifurcation of the beam which has not been addressed in the existing literature. Apart from this, the impact of fluctuating velocity component, viscoelastic coefficient, longitudinal stiffness parameter, internal and parametric detuning parameters on the stability and bifurcation analysis is studied, revealing significant dynamic characteristics of the traveling system. The Fourth-order Runge-Kutta method is applied is to find the dynamic solution of the system. The system displays stable periodic, quasi-periodic, and mixed-mode dynamic responses along with the unstable chaotic behavior for a specific set of system parameters. The results obtained through an analytical-numerical approach may help the design and operation of an axially moving beam.
An infantile traumatic brain injury with a bright tree appearance detected before the late seizure
Authors: Kaneko Naoki , Nishizawa Hideo , Fujimoto Junichi , Nanao Taikan , Kimura Yasuhiro , Owada Gen 
Published: June 2022

Abstract
Infantile traumatic brain injury (TBI) rarely follows a biphasic clinical course and exhibits a bright tree appearance (BTA) on magnetic resonance imaging (MRI). This is termed infantile traumatic brain injury with a biphasic clinical course and late reduced diffusion (TBIRD). TBIRD has clinical features similar to those of acute encephalopathy with biphasic seizures and late reduced diffusion (AESD). It remains to be clarified which patients with infantile TBI will develop TBIRD and the prevention and treatment of TBIRD. We report a case of TBIRD that exhibited BTA 1 day before the late seizure and review 12 cases of TBIRD. All patients developed a subdural hematoma (SDH), were younger than 2 years, and presented with a biphasic phase within 3-6 days. The median interval between BTA and TBI was 5 days. Of the 5 cases examined with MRI before the biphasic phase, only our case was detected with BTA 4 days after TBI. Therefore, predicting the biphasic clinical course may be possible by examining MR images after TBI in patients under 2 years of age who develop SDH with unconsciousness, seizure, or hemiplegia, and these patients should be strictly followed up for 1 week.
Analysis of inguinal hernia in children: Experience of a single institution with 1185 cases
Authors: DURSUN Ahmet , ÖZTAŞ Tülin 
Published: June 2022

Abstract
Purpose: In this study, we aimed to give an overview of inguinal hernia in children, recognize the experiences of our clinic and compare them with the literature.Methods: A total of 1185 patients who underwent inguinal hernia repair between August 2016 and February 2022 were included in this study. Patients' age, gender, inguinal hernia type, hernia side, incarceration, contralateral hernia formation, recurrence and other related complications were evaluated. Results: Of the patients, 71% were male, and 29% were female (2.44:1). Patients’ ages ranged from five days to 17 years (mean 51 ± 42 months). Hernia was on the right side in 58.6% patients, on the left side in 30.3% patients, and bilateral in 11.1% patients. Contralateral hernia developed in 2.6% of the patients and there was no difference between gender regarding incidence (p>0.05). Postoperative complications developed in 5.2% of the patients. All eight patients who developed hernia recurrence were male. The proportion of patients who were operated on for incarcerated hernia was 1.7%. Conclusion: There was no difference between the genders regarding the percentage of sides (p>0.05). The rate of recurrent hernia was higher under the age of one. We found that the rate of incarceration increased with low gestational age. We conclude that routine contralateral inguinal exploration is not indicated. The complication rate is higher in patients with multiple comorbidities in hernia patients.