bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stripy zinc array with preferential crystal plane for the ultra‐long lifespan of zinc metal anodes for zinc ion batteries
Authors: Su Ting‐Ting , Wang Ke , Chi Bing‐Yu , Ren Wen‐Feng , Sun Run‐Cang 
Published: May 2022

AbstractRechargeable zinc (Zn) batteries have been regarded as a potential alternative for energy storage instrument, but the poor life‐span of Zn metal anodes restrain their commercial application. In this work, stripy Zn array (ZnSA) with preferential (002) crystal plane was designed and fabricated through the facile treatment with concentrated phosphoric acid. The depth of stripy array and the content of (002) plane were controlled through the optimization of etching time. The synergistic effect of stripy morphology and preferential crystal plane can increase the electroactive surface area, suppress the corrosion and hydrogen evolution of aqueous electrolyte, induce the horizontal growth along with basal (002) plane, and inhibit the formation of Zn dendrites. The as‐synthesized ZnSA electrodes can achieve ultra‐long lifespan of 2500 h at the current density of 2 mA cm−2 with a constant capacity of 2 mAh cm−2 and still maintain stable cycling of 1200 and 1400 h even at the higher current density of 10 mA cm−2 and plating/stripping depth of 5 mAh cm−2, respectively. This work proposes a facile and effective strategy to improve electrochemical performance of metallic Zn anodes and contributes to the commercial application of Zn ion batteries.image
Doping metal–organic framework composites to antibacterial air filter development for quality control of indoor air
Authors: Zendehdel Rezvan , Amini Mostafa M. , Hajibabaei Majid , Nasiri Mohammad Javad , Jafari Mohammad Javad , Alavijeh Masoumeh Karimi 
Published: May 2022

AbstractBuilding airtightness for acquiring greater energy efficiency have impacted indoor air quality. The control of pollution requires air filtration. Bioaerosols serve as an essential quality indicator of indoor air. The contamination of bioaerosols is a filtration barrier. The present study proposes a novel metal–organic framework (MOFs) antimicrobial air filter. This study is the first to employ Ag/MOFs/IMI in order to build an air filter for the deactivation and removal of indoor airborne microbes. The media of the Ag/MOFs/IMI/EPA filter was fabricated using the dip‐coating of Ag/MOFs/IMI by imidazole and silver NPs. The deactivation and removal efficiency of the Ag/MOFs/IMI/EPA filter was assessed by bioaerosols, including “Escherichia coli” (E. coli) and “Staphylococcus aureus” (S. aureus) within a closed‐loop chamber at the RH degrees of 30% and 70%. The findings suggested that the Ag/MOFs/IMI filter's removal efficiency by nearly 17.88% without significant increase in pressure drop in comparison to the raw EPA filter for the bioaerosol of S. aureus. Furthermore, the Ag/MOFs/IMI filter media's deactivation efficiency under 3% loading was obtained to be 95.62% ± 1.2% and 99.4% ± 3.25% for the bioaerosol of S. aureus at an RH of 30% and 70%, respectively. Moreover, the E. coli deactivation efficiency under an Ag/MOFs/IMI loading of 1% was found to be 68.33% ± 1.98% and 96.27% ± 3.04% for an RH of 30% and 70%, respectively. The findings indicated the Ag/MOFs/IMI filter's media to be able to effectively inactivate bioaerosols and prevent their spread from the air filter into the indoor place. Furthermore, these findings provide a pioneer contribution to the antibacterial quality development of commercial filters.
Analysis of Planning Strategies for Sustainable Electricity Generation in Kenya from 2015 to 2035
Authors: Maina Alex , Makathimo Mwenda , Adwek George , Opiyo Charles 
Published: May 2022

AbstractThis research entails the simulation of three possible power scenarios for Kenya from 2015 to 2035 using low emissions analysis platform (LEAP). These scenarios represent the unfolding future electricity generation that will fully satisfy the demand while considering the following: energy security, power generation cost, and impacts on the environment. These scenarios are reference scenario (RS), coal scenario (CS), nuclear scenario (NS), and more renewable scenario (MRS). The findings obtained reveals that the most sustainable scenario while comparing the costs was found to be the coal scenario with a net present value (NPV) of $30 052.67 million though it has the highest greenhouse gases (GHGs) emissions. However, the more renewable scenario (MRS) has the least GHGs emissions but is found to be the most expensive scenario to implement with an NPV of $30 733.07 million.
Statistical methods for Mendelian models with multiple genes and cancers
Authors: Liang Jane W. , Idos Gregory E. , Hong Christine , Gruber Stephen B. , Parmigiani Giovanni , Braun Danielle 
Published: May 2022

AbstractRisk evaluation to identify individuals who are at greater risk of cancer as a result of heritable pathogenic variants is a valuable component of individualized clinical management. Using principles of Mendelian genetics, Bayesian probability theory, and variant‐specific knowledge, Mendelian models derive the probability of carrying a pathogenic variant and developing cancer in the future, based on family history. Existing Mendelian models are widely employed, but are generally limited to specific genes and syndromes. However, the upsurge of multigene panel germline testing has spurred the discovery of many new gene–cancer associations that are not presently accounted for in these models. We have developed PanelPRO, a flexible, efficient Mendelian risk prediction framework that can incorporate an arbitrary number of genes and cancers, overcoming the computational challenges that arise because of the increased model complexity. We implement an 11‐gene, 11‐cancer model, the largest Mendelian model created thus far, based on this framework. Using simulations and a clinical cohort with germline panel testing data, we evaluate model performance, validate the reverse‐compatibility of our approach with existing Mendelian models, and illustrate its usage. Our implementation is freely available for research use in the PanelPRO R package.
Review of carbon capture absorbents for CO2utilization
Authors: Chai Slyvester Yew Wang , Ngu Lock Hei , How Bing Shen 
Published: May 2022

AbstractCarbon capture technologies have been recognized as a potential alternative to alleviate global warming. Carbon capture and storage (CCS) is preferred over carbon conversion and utilization (CCU) due to its lower operating costs and higher CO2reduction capability. Nevertheless, CO2utilization has the potential to be more economical if value‐added products are produced. This highlights the importance of assessing CO2utilization routes and alternatives in carbon management. This review paper aims to evaluate the carbon utilization potential of major CO2‐capturing absorbents including amine, hydroxide, ionic liquid, amino acids and carbonate absorbents. All absorbents show potential application for CO2utilization except for ionic liquids (ILs) due to their unclear CO2capture mechanisms. Absorbents that require a desorption process for CO2utilization include MEA, MDEA, K2CO3and Na2CO3due to their high absorption capacity. Industries have utilized the desorbed CO2as chemical feedstocks, enhanced oil recovery (EOR) and mineral carbonation. For hydroxide absorbents and CaCO3, desorption of CO2is unnecessary as the absorbed CO2can be directly utilized to produce construction materials. Apart from that, the incorporation of advanced technologies and business models introduced by the fourth industrial revolution are plausible considerations to accelerate the development of carbon capture technologies. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd.
Geochronology and petrogenesis of granitoids and associated mafic enclaves from Ghohroud in the Urumieh–Dokhtar Magmatic Arc (Iran): Evidence for magma mixing during the closure of the Neotethyan Ocean
Authors: Khaksar Tayebeh , Rashidnejad‐Omran Nematollah , Li Shuang‐Qing , Song Shu‐Guang , Kananian Ali , Chen Fukun , Li Su 
Published: May 2022

The Ghohroud granitoids (GG), containing mafic microgranular enclaves (MMEs) are located in the central part of the Urumieh‐Dokhtar Magmatic Arc (UDMA) in central Iran. They are associated with the subduction‐related magmatism in the Alpine‐Himalayan orogenic belt. The GG are comprised of a variety of intermediate and felsic rocks, including tonalite, granodiorite, granite, diorite porphyry and monzodiorite. The MMEs are gabbroic diorite and tonalite in composition and characterized by a fine‐grained hypidiomorphic microgranular texture with occasional chilled margins. They show rounded, sharp or irregular contact with the host granitoids. The occurrences of quartz, K‐feldspar and corroded plagioclase indicate that MMEs are the products of mixing between mantle and crust‐derived magmas. New ages of zircon U–Pb dating reveal that the GG in the Kashan area emplaced at ca. 19–17 Ma (Burdigalian). All the samples of MMEs and granitoid host rocks in this study are metaluminous and calc‐alkaline with I‐type affinities. They are enriched in light rare earth elements (LREEs) and show slight negative Eu anomalies (Eu/Eu* = 0.36–0.95). These features in a combination with the relative depletion in Nb, Ta, Ti and P, indicate the granitoids and MMEs are closely associated with subduction‐related magmas at an active continental margin. The host rocks yield relatively homogeneous isotopic compositions of initial 87Sr/86Sr ratios ranging from 0.706036 to 0.707055, εNd(t) values varying from −2.25 to 0.8, and the Nd model ages (TDM) vary in a limited range of 0.70–0.96 Ga. The MMEs show similar initial 87Sr/86Sr ratios (0.706420–0.707366), εNd(t) values (−1.32 to −0.27), TDM (0.68–1.09 Ga) and Pb isotopic compositions with host granitoids, which imply they attained isotopic equilibration during magma mingling and mixing. In combination with the petrographic, chemical and isotopic results, we suggest that the origin of MMEs and their host rocks were related to the interaction between crust‐derived melts and mantle‐derived mafic magmas. The magma‐mixing event possibly occurred during the transition from subduction to collision in the UDMA along with the closure of the Neotethyan ocean.
Safety evaluation of mutagenicity, genotoxicity, and cytotoxicity of Lactobacillus spp. isolates as probiotic candidates
Authors: Darbandi Atieh , Mirkalantari Shiva , Golmoradi Zadeh Rezvan , Esghaei Maryam , Talebi Malihe , Kakanj Maryam 
Published: May 2022

AbstractBackgroundProbiotics promote a healthy balance of gut bacteria and have many beneficial effects on human digestive physiology. Although, few side effects of probiotics have been reported. This study aimed to assess the safety of five probiotic candidate Lactobacillus strains isolated from healthy individuals by examining mutagenicity, genotoxicity, and oral toxic effects.MethodsFive selected candidate probiotic (SCPs) strains were evaluated for genotoxicity (Ames test with Salmonella typhimurium), in vitro mammalian chromosome aberration test and an in vivo mouse micronucleus assay on peripheral blood of mice. To evaluate the oral dose toxicity, BALB/c mice models were treated repeatedly (2000, 1000, and 500 mg/kg body weight /day) for 28‐days.ResultsThe Ames test performed for two S. typhimurium strains TA 98 and TA100 (both in the absence and in the presence of S‐9 metabolic activation system) did not show an increase in reverse mutation because of exposure to the SCPs in any of the doses (5.0, 2.5, 1.25, 0.625, and 0.3125 mg/plate). There was no genotoxicity in the SCPs treatment in the vitro chromosome aberration assay with Chinese hamster ovary cells (CHO‐K1). In addition, none of the tested strains increased the frequency of micronucleated reticulocytes in reticulocytes, the SCPs with the studied doses caused no substantial variation in the experimental groups compared to the negative control group (p > 0.05). SCPs were not acutely toxic when administered to male and female BALB/c mice by single gavage at (2000, 1000, and 500 mg/kg b.w/day) with no mortality or clinical signs, change in body weight or macroscopic abnormalities were observed in this dose range.ConclusionAs a result, SCPs did not induce mutagenic potential in vitro with bacterial reverse mutation, clastogenicity, and in vivo tests in the ranges of concentrations evaluated in our study.
The impact of a violent community on mental health and the benefits of a sport program for social development
Authors: Fernandes Orlando , Marra da Silva Ruy , Rego Ramos Lucas , Gama Tamires M. , Lobo Isabela , Guerra Leal Souza Gabriela , Arruda Sanchez Tiago 
Published: May 2022

AbstractThe aim of the present study was to evaluate the impact of a violent environment on mental health and the impact of a sport for social development (SSD) program on quality of life, mental distress symptoms, and heart rate variability (HRV). HRV and psychometric data were measured from 20 men professional athletes assisted by the SSD and 20 men living in the same violent community. The comparison of groups revealed greater sympathetic parameters of HRV, positive affect, and quality of life in the SSD group. Multiple regression analysis showed that the quality of life in the SSD group was positively predicted by positive affect, while in the control group the quality of life was negatively predicted by their history of traumatic events. Both groups reported high levels of exposure to traumatic events and posttraumatic stress symptoms. However, this study demonstrates the benefits of SSD programs in mental health.
Role of complement components in vasculitic neuropathy associated with systemic lupus erythematosus and rheumatoid arthritis
Authors: Fukami Yuki , Koike Haruki , Iijima Masahiro , Mouri Naohiro , Nishi Ryoji , Katsuno Masahisa 
Published: May 2022

AbstractIntroduction/AimsThe mechanism of complement‐mediated neurological injury in vasculitic neuropathy associated with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) is unknown. The current study aimed to investigate the local activation of the complement system in vasculitic neuropathy associated with SLE and RA.MethodsWe analyzed sural nerve biopsy specimens collected from patients with SLE (n = 12) and RA (n = 12). The deposition of complement components comprising the classical and lectin pathways was assessed via immunohistochemistry.ResultsThe disease duration was longer in the RA group than in the SLE group (median [interquartile range]: 11.5 [5.5–31.0] and 4 [2–10] y, respectively). Complement components were found in the epineurial blood vessel walls in patients with SLE and RA, but not in controls. Deposition of the classical pathway component C1q in the blood vessel wall was more commonly observed in the SLE group (71.3% [25.6–85.8]) than in the RA group (20.1% [10.5–35.6]). As for the lectin pathway component, the incidence of ficolin‐3 deposition in the blood vessel wall was higher in the SLE group (42.3% [25.7–51.3]) than in the RA group (17.2% [10.3–26.8]). On the contrary, the mannose‐binding lectin level was higher in the RA group (37.5% [21.7–51.4]) than in the SLE group (17.8% [11.4–31.0]).DiscussionThe classical and lectin pathways of the complement system may be involved in vasculitic neuropathy associated with SLE and RA.
A neural network‐enhanced reproducing kernel particle method for modeling strain localization
Authors: Baek Jonghyuk , Chen Jiun‐Shyan , Susuki Kristen 
Published: May 2022

AbstractModeling the localized intensive deformation in a damaged solid requires highly refined discretization for accurate prediction, which significantly increases the computational cost. Although adaptive model refinement can be employed for enhanced effectiveness, it is cumbersome for the traditional mesh‐based methods to perform while modeling the evolving localizations. In this work, neural network‐enhanced reproducing kernel particle method (NN‐RKPM) is proposed, where the location, orientation, and shape of the solution transition near a localization is automatically captured by the NN approximation via a block‐level neural network (NN) optimization. The weights and biases in the blocked parameterization network control the location and orientation of the localization. The designed basic four‐kernel NN block is capable of capturing a triple junction or a quadruple junction topological pattern, while more complicated localization topological patters are captured by the superposition of multiple four‐kernel NN blocks. The standard RK approximation is then utilized to approximate the smooth part of the solution, which permits a much coarser discretization than the high‐resolution discretization needed to capture sharp solution transitions with the conventional methods. A regularization of the NN approximation is additionally introduced for discretization‐independent material responses. The effectiveness of the proposed NN‐RKPM is verified by a series of numerical verifications.
Reference values and equations for the 6‐minute walk distance of Nigerian children aged 6–11 years: A cross‐sectional study
Authors: Ubuane Peter Odion , Ajiboye Olufunke Adewumi , Adekunle Motunrayo Oluwabukola , Akinola Ayodeji Olushola , Akinyosoye Gbenga , Kayode‐Awe Mogbafolu Olugbemiga , Ajayi Omotola Aderiyike , Ohagwu Chidimma Imma , Animasahun Barakat Adeola , Njokanma Fidelis Olisamedua 
Published: May 2022

AbstractBackgroundThe 6‐minute walk test (6MWT), a simple, reliable, and valid test that uses the distance walked in 6 minute walk distance (6MWD) to quantify functional capacity, is widely used in the management of chronic disorders. However, the absence of reference standards from sub‐Saharan African, including Nigerian, school‐aged children limits its utility in this age group.ObjectivesTo develop normative values and equations for the 6MWD of school‐aged Nigerian children.MethodsIn a cross‐sectional study, healthy children aged 6–11 years in Lagos, Nigeria, completed the 6MWT on 20‐m‐long straight outdoor courses in their schools. The primary outcome was the 6MWD in meters while potential predictors included demographic (age, sex), anthropometric (height, weight, chest circumference, leg length) and physiologic variables (pre‐walk, immediate post‐walk, and fifth min‐post‐walk heart rate [HR], oxygen saturation [SpO2], systolic blood pressure [SBP], diastolic blood pressure [DBP], and rating of perceived exertion [RPE]; and the difference between pre‐walk and post‐walk HR [∆HR], SpO2 [∆SpO2], SBP [∆SBP], DBP [∆DBP], and RPE [∆RPE]).ResultsOverall, 627 pupils (52.1% girls) walked 504.6 ± 66.6 m (95% CI: 499.4, 509.8; range: 326.6–673.0 m); 16 m longer in boys (p = 0.002). A stepwise linear regression model yielded: 6MWD (m) = 347.9 + 14(Ageyears) + 1.6 (∆HRbeats/min) + 17.6(Sexmale=1, female=0) + 1.2(∆SBPmmHg); R2 = 0.25. Previously published reference equations mostly over‐estimated Nigerian children's 6MWD.ConclusionThese reference standards add to the global normative data on pediatric 6MWT and may be useful for the functional evaluation of Nigerian school‐aged children with chronic childhood disorders.
An integrated approach reveals how lipo‐chitooligosaccharides interact with the lysin motif receptor‐like kinase MtLYR3
Authors: Bouchiba Younes , Esque Jérémy , Cottret Ludovic , Maréchaux Maude , Gaston Mégane , Gasciolli Virginie , Keller Jean , Nouwen Nico , Gully Djamel , Arrighi Jean‐François , Gough Clare , Lefebvre Benoit , Barbe Sophie , Bono Jean‐Jacques 
Published: May 2022

AbstractN‐acetylglucosamine containing compounds acting as pathogenic or symbiotic signals are perceived by plant‐specific Lysin Motif Receptor‐Like Kinases (LysM‐RLKs). The molecular mechanisms of this perception are not fully understood, notably those of lipo‐chitooligosaccharides (LCOs) produced during root endosymbioses with nitrogen‐fixing bacteria or arbuscular mycorrhizal fungi. In Medicago truncatula, we previously identified the LysM‐RLK LYR3 (MtLYR3) as a specific LCO‐binding protein. We also showed that the absence of LCO binding to LYR3 of the non‐mycorrhizal Lupinus angustifolius, (LanLYR3), was related to LysM3, which differs from that of MtLYR3 by several amino acids and, particularly, by a critical tyrosine residue absent in LanLYR3. Here, we aimed to define the LCO binding site of MtLYR3 by using molecular modelling and simulation approaches, combined with site‐directed mutagenesis and LCO binding experiments. 3D models of MtLYR3 and LanLYR3 ectodomains were built, and homology modelling and molecular dynamics (MD) simulations were performed. Molecular docking and MD simulation on the LysM3 identified potential key residues for LCO binding. We highlighted by steered MD simulations that in addition to the critical tyrosine, two other residues were important for LCO binding in MtLYR3. Substitution of these residues in LanLYR3‐LysM3 by those of MtLYR3‐LysM3 allowed the recovery of high‐affinity LCO binding in experimental radioligand‐binding assays. An analysis of selective constraints revealed that the critical tyrosine has experienced positive selection pressure and is absent in some LYR3 proteins. These findings now pave the way to uncover the functional significance of this specific evolutionary pattern.
Phytochemistry, synthesis, analytical methods, pharmacological activity, and pharmacokinetics of loganin: A comprehensive review
Authors: Zhang Fan , Yan Yu , Zhang Jia , Li Li , Wang Yu‐Wei , Xia Cong‐Yuan , Lian Wen‐Wen , Peng Ying , Zheng Jiang , He Jun , Xu Jie‐Kun , Zhang Wei‐Ku 
Published: May 2022

AbstractIridoid glycosides (IGs) are found in many medicinal and edible plants, such as Gardenia jasminoides, Cistanche tubulosa, Eucommia ulmoides, Rehmanniae Radix, Lonicera japonica, and Cornus officinalis. Loganin, an IG, is one of the main active ingredient of Cornus officinalis Sieb. et Zucc., which approved as a medicinal and edible plant in China. Loganin has been widely concerned due to its extensive pharmacological effects, including anti‐diabetic, antiinflammatory, neuroprotective, and anti‐tumor activities, etc. Studies have shown that these underlying mechanisms include anti‐oxidation, antiinflammation and anti‐apoptosis by regulating a variety of signaling pathways, such as STAT3/NF‐κB, JAK/STAT3, TLR4/NF‐κB, PI3K/Akt, MCP‐1/CCR2, and RAGE/Nox4/p65 NF‐κB signaling pathways. In order to better understand the research status of loganin and promote its application in human health, this paper systematically summarized the phytochemistry, analysis methods, synthesis, pharmacological properties and related mechanisms, and pharmacokinetics based on the research in the past decades.
The stability investigation of variable viscosity control in the human‐robot interaction
Authors: Dong Lin , Perrin Nicolas , Richer Florian , Roby‐Brami Agnes , Morel Guillaume 
Published: May 2022

AbstractBackgroundFor many co‐manipulative applications, variable damping is a valuable feature provided by robots. One approach is implementing a high viscosity at low velocities and a low viscosity at high velocities. This, however, is proven to have the possibility to alter human natural motion performance.MethodsWe show that the distortion is caused by the viscosity drop resulting in robot's resistance to motion. To address this, a method for stably achieving the desired behaviour is presented. It involves leveraging a first‐order linear filter to slow the viscosity variation down.ResultsThe proposition is supported by a theoretical analysis using a robotic model. Meanwhile, the user performance in human‐robot experiments gets significantly improved, showing the practical efficiency in real applications.ConclusionsThis paper discusses the variable viscosity control in the context of co‐manipulation. An instability problem and its solution were theoretically shown and experimentally evidenced through human‐robot experiments.