bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spinetoram resistance drives interspecific competition between Megalurothrips usitatus and Frankliniella intonsa
Authors: Fu Buli , Tao Min , Xue Hu , Jin Haifeng , Liu Kui , Qiu Haiyan , Yang Shiyou , Yang Xin , Gui Lianyou , Zhang Youjun , Gao Yulin 
Published: February 2022

AbstractBACKGROUNDSpecies displacement by the outcome of interspecific competition is of particular importance to pest management. Over the past decade, spinetoram has been extensively applied in control of the two closely related thrips Megalurothrips usitatus and Frankliniella intonsa worldwide, while whether its resistance is implicated in mediating interspecific interplay of the two thrips remains elusive to date.RESULTSField population dynamics (from 2017 to 2019) demonstrated a trend toward displacement of F. intonsa by M. usitatus on cowpea crops, supporting an existing interspecific competition. Following exposure to spinetoram, M. usitatus became the predominate species, which suggests the use of spinetoram appears to be responsible for mediating interspecific interactions of the two thrips. Further annual and seasonal analysis (from 2016 to 2020) of field‐evolved resistance dynamics revealed that M. usitatus developed remarkably higher resistance to spinetoram compared to that of F. intonsa, implying a close relationship between evolution of spinetoram resistance and their competitive interactions. After 12 generations of laboratory selection, resistance to spinetoram in M. usitatus and F. intonsa increased up to 64.50‐fold and 28.33‐fold, and the average realized heritability (h2) of resistance was calculated as 0.2550 and 0.1602, respectively. Interestingly, two‐sex life table analysis showed that the spinetoram‐resistant strain of F. intonsa exhibited existing fitness costs, but not the M. usitatus. These indicate that a rapid development of spinetoram resistance and the lack of associated fitness costs may be the mechanism underlying recent dominance of M. usitatus over F. intonsa.CONCLUSIONCollectively, our results uncover the involvement of insecticide resistance in conferring displacement mechanism behind interspecific competition, providing a framework for understanding the significance of the evolutionary relationships among insects under ongoing changing environments. These findings also can be invaluable in proposing the most appropriate strategies for sustainable thrips control programs. © 2022 Society of Chemical Industry.
Control charts for health surveillance based on residuals of negative binomial regression
Authors: García‐Bustos Sandra , Zambrano Gema 
Published: February 2022

AbstractThis research presents control charts based on one‐sided exponentially weighted moving average (EWMA) control charts of Pearson, studentized Pearson, Deviance, and Studentized Deviance residuals for a negative binomial regression in order to detect increases in count quality variables used in health surveillance. Data of weekly dengue cases for the year 2018 from the coast of Ecuador were used for the design of control charts in phase I because in that year the weather conditions were normal, while dengue cases in 2019 were used for phase II of control. The control charts detected an increase in the weekly cases of dengue during 2019, a year in which the phenomenon of the Niño was present. In this study by simulations, it is shown that the smallest lambda values have a faster speed in detecting changes. If the objective is greater sensitivity, using studentized residuals is better, but if we seek simplicity and interpretation, Pearson residuals can be used.
Full‐thickness defect reconstruction of the pinna using a distant direct skin flap technique in three dogs
Authors: Chatzimisios Kyriakos , Angelou Vasileia , Biskas Petros , Svigkas Panagiotis , Papazoglou Lysimachos G. 
Published: February 2022

AbstractThree dogs were referred for further investigation and pinna reconstruction. Two dogs presented with pinna defects secondary to dog fights and one dog with a pinna mass. Cytologic examination of the pinna mass was consistent with a cutaneous benign histiocytoma, thus surgical excision was performed leaving a full‐thickness pinna defect. In all three dogs, full‐thickness pinna defects were reconstructed using a two‐stage pedicle flap that originated from the skin of either the neck region or the dorsum of the head. Time interval between the two stages of the surgical procedure was 2 weeks. Postoperative complications included dehiscence, poor ear carriage and failure of complete coverage of the defect. At a median follow‐up of 7 months, cosmetic results were fair to good.
Two-stage regional rare-element pegmatite formation at Tysfjord, Norway: implications for the timing of late Svecofennian and late Caledonian high-temperature events
Authors: Müller Axel , Romer Rolf L. , Augland Lars Eivind , Zhou Haoyang , Rosing-Schow Nanna , Spratt John , Husdal Tomas 
Published: February 2022

AbstractPegmatite fields within granite plutons are commonly considered to have formed from residual melts of their host. This is not always true as demonstrated by the Tysfjord granite gneiss and its two groups of pegmatites. The Tysfjord granite gneiss, exposed in a tectonic window of the Caledonides of northern Norway, is part of the transscandinavian igneous belt (TIB) that includes several phases of granitic magmatism. In the northern Hamarøy area (Drag-Finnøy), where most rare-element pegmatites occur, Paleoproterozoic and metamorphosed Group 1 allanite–(Ce)–fluorite metapegmatites have similar bulk rock chemical composition as the TIB granite gneiss rocks, indicating that these pegmatites are residual melts. Group 1 metapegmatites, which are up to 400 m in size, are among the largest known intra-plutonic pegmatites with Nb–Y–F (NYF) signature. The formation of these unusually large granite-hosted NYF pegmatites may have been facilitated by the overall high F content of TIB granite gneisses. Undeformed Group 2 amazonite–tourmaline pegmatites yield columbite and zircon U–Pb ages in the range 400–379 Ma. These pegmatites are interpreted to be anatectic melts that formed from the partial melting of Tysfjord granite gneiss. Group 2 pegmatites, including those from Træna Island and the Sjona tectonic window (400 and 414 Ma), formed during late Caledonian ductile shearing and incipient unroofing of the central Scandinavian Caledonides and record progressively younger ages of this event from SW to NE.
How I do it: decompressive hemicraniectomy supplemented with resection of the temporal pole and tentoriotomy for malignant ischemic infarction in the territory supplied by the middle cerebral artery
Authors: Sehweil Salah M. M. , Goncharova Zoya Alexandrovna 
Published: February 2022

Abstract
Abstract
Malignant ischemic infarction in the territory supplied by the middle cerebral artery is an extremely severe form of ischemic stroke associated with development of massive uncontrollable postischemic edema of the affected cerebral hemisphere; the end result of which is development of transtentorial herniation and death.

Method
The surgical technique of performance of decompressive hemicraniectomy involves removal of an extensive bone flap in the fronto-temporo-parieto-occipital zone with resection of the temporal squama and of the greater wing of the sphenoid bone to visualize the level of entrance of the middle meningeal artery to the cranial cavity, which, in its turn, allows resection of the upright margin of the middle cranial fossa. Decompressive hemicraniectomy is supplemented with resection of the temporal pole and tentoriotomy.

Conclusion
Performance of decompressive hemicraniectomy in combination with resection of the resection of the temporal pole and tentoriotomy is an effective surgical method of treatment of malignant ischemic stroke in the territory supplied by the middle cerebral artery, capable of reducing the lethality rate during the postoperative period.
Differing pan-coronavirus antiviral potency of boceprevir and GC376 in vitro despite discordant molecular docking predictions
Authors: Wang Yining , Li Pengfei , Lavrijsen Marla , Li Yang , Ma Zhongren , Peppelenbosch Maikel P. , Baig Mirza S. , Pan Qiuwei 
Published: February 2022

AbstractGiven the structural similarities of the viral enzymes of different coronaviruses (CoVs), we investigated the potency of the anti-SARS-CoV-2 agents boceprevir and GC376 for counteracting seasonal coronavirus infections. In contrast to previous findings that both boceprevir and GC376 are potent inhibitors of the main protease (Mpro) of SARS-CoV-2, we found that GC376 is much more effective than boceprevir in inhibiting SARS-CoV-2 and three seasonal CoVs (NL63, 229E, and OC43) in cell culture models. However, these results are discordant with a molecular docking analysis that suggested comparable affinity of boceprevir and GC376 for the different Mpro enzymes of the four CoVs. Collectively, our results support future development of GC376 but not boceprevir (although it is an FDA-approved antiviral medication) as a pan-coronavirus antiviral agent. Furthermore, we caution against overinterpretation of in silico data when developing antiviral therapies.
Utility of whole exome sequencing analysis in differentiating intrapulmonary metastatic multiple ground-glass nodules (GGNs) from multiple primary GGNs
Authors: Zhou Dong , Liu Quan-Xing , Li Man-yuan , Hou Bin , Yang Gui-xue , Lu Xiao , Zheng Hong , Jiang Li , Dai Ji-Gang 
Published: February 2022

Abstract
Purpose
Clinical evidence of metastasis with ground-glass nodules (GGNs) has been reported, including pulmonary metastasis and distant metastasis. However, the clonal relationships of multiple GGNs at the genetic level remain unclear.

Experimental design
Sixty tissue specimens were obtained from 19 patients with multiple GGN lung cancer who underwent surgery in 2019. Whole exome sequencing (WES) was performed on tissue samples, and genomic profiling and clone evolution analysis were conducted to investigate the genetic characteristics and clonality of multiple GGNs.

Results
A total of 15,435 nonsynonymous mutations were identified by WES, and GGNs with shared nonsynonymous mutations were observed in seven patients. Copy number variant (CNV) analysis showed that GGNs in ten patients had at least one shared arm-level CNV. Mutational spectrum analysis showed that GGNs in three patients had similar six substitution profiles and GGNs in fou patients had similar 96 substitution profiles. According to the clone evolution analysis, we found that GGNs in five patients had shared clonal driver gene mutations. Taken together, we identified that 5 patients may have multiple primary GGNs without any similar genetic features, 2 patients may have intrapulmonary metastatic GGNs with ≥ 3 similar genetic features, and the other 12 patients cannot be determined due to insufficient evidences in our cohort.

Conclusions
Our findings suggest that the intrapulmonary metastasis exist in multiple GGNs, but the number of GGNs was not associated with the probability of metastasis. Application of genomic profiling may prove to be important to precise management of patients with multiple GGNs.
Adaptive forecast-driven repositioning for dynamic ride-sharing
Authors: Pouls Martin , Ahuja Nitin , Glock Katharina , Meyer Anne 
Published: February 2022

AbstractIn dynamic ride-sharing systems, intelligent repositioning of idle vehicles often improves the overall performance with respect to vehicle utilization, request rejection rates, and customer waiting times. In this work, we present a forecast-driven idle vehicle repositioning algorithm. Our approach takes a demand forecast as well as the current vehicle fleet configuration as inputs and determines suitable repositioning assignments for idle vehicles. The core part of our approach is a mixed-integer programming model that aims to maximize the acceptance rate of anticipated future trip requests while minimizing vehicle travel times for repositioning movements. To account for changes in current trip demand and vehicle supply, our algorithm adapts relevant parameters over time. We embed the repositioning algorithm into a planning service for vehicle dispatching. We evaluate our forecast-driven repositioning approach through extensive simulation studies on real-world datasets from Hamburg, New York City, Manhattan, and Chengdu. The algorithm is tested assuming a perfect demand forecast and applying a naïve forecasting model. These serve as an upper and lower bound on state-of-the-art forecasting methods. As a benchmark algorithm, we utilize a reactive repositioning scheme. Compared to this, our forecast-driven approach reduces trip request rejection rates by an average of 3.5 percentage points and improves customer waiting and ride times.
The effects of serious gaming on risk perceptions of climate tipping points
Authors: van Beek Lisette , Milkoreit Manjana , Prokopy Linda , Reed Jason B. , Vervoort Joost , Wardekker Arjan , Weiner Roberta 
Published: February 2022

AbstractA growing body of research indicates that effective science-policy interactions demand novel approaches, especially in policy domains with long time horizons like climate change. Serious games offer promising opportunities in this regard, but empirical research on game effects and games’ effectiveness in supporting science-policy engagement remains limited. We investigated the effects of a role-playing simulation game on risk perceptions associated with climate tipping points among a knowledgeable and engaged audience of non-governmental observers of the international climate negotiations and scientists. We analysed its effects on concern, perceived seriousness, perceived likelihood and psychological distance of tipping points, using pre- and post-game surveys, debriefing questions and game observations. Our findings suggest that the game reduced the psychological distance of tipping points, rendering them more ‘real’, proximate and tangible for participants. More generally, our findings indicate that role-playing simulation games, depending on their design and future orientation, can provide effective science-policy engagement tools that allow players to engage in future thinking and corresponding meaning making.
Characteristics and outcomes of recurrent atrial fibrillation after prior failed pulmonary vein isolation
Authors: Vanam Sai , Darden Douglas , Munir Muhammad Bilal , Aldaas Omar , Hsu Jonathan C. , Han Frederick T. , Hoffmayer Kurt S. , Raissi Farshad , Birgersdotter-Green Ulrika , Feld Gregory K. , Krummen David E. , Ho Gordon 
Published: February 2022

Abstract
Background
The mechanisms for atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI) catheter ablation are unclear. Non-PV organized atrial arrhythmias (PAC, AT, macro-reentrant AFL) are possible contributors; however the prevalence and effect of their ablation on recurrent AF are unknown. We hypothesize that the identification and ablation of non-PV organized atrial arrhythmias were associated with less AF recurrence.

Methods
Patients who underwent repeat ablation for recurrent AF after prior PVI were retrospectively enrolled. The prevalence and characteristics of PV reconnections and non-PV organized atrial arrhythmias were identified. The outcomes of time to clinical AF recurrence, heart failure (HF) hospitalization, and mortality were analyzed in patients using multivariable adjusted Cox regression.

Results
In 74 patients with recurrent AF (age 66 ± 9 years, left atrial volume index 38 ± 10 ml/m2, 59% persistent AF), PV reconnections were found in 46 patients (61%), macro-reentrant atrial flutter in 27 patients (36%), and focal tachycardia in 12 patients (16%). Mapping and ablation of non-PV organized atrial arrhythmias were associated with a reduced recurrence of late clinical AF (adjusted HR 0.26, CI 0.08–0.85, p = 0.03) and the composite outcome of recurrence of late AF, HF hospitalization, and mortality (adjusted HR 0.38, CI 0.17–0.85, p = 0.02), with median follow-up of 1.6 (IQR 0.7–6.3) years. The presence of PV reconnections or empiric linear ablation was not associated with reduction in clinical AF or composite endpoints.

Conclusion
The ablation of non-PV organized atrial arrhythmias resulted in a reduction of late clinical AF recurrence and composite outcome. In this challenging population, alternate mechanisms beyond PV reconnections need to be considered. Prospective studies are needed.
Testing the public’s response to receiving severe flood warnings using simulated cell broadcast
Authors: Smith Kate R. , Grant Silvia , Thomas Robert E. 
Published: February 2022

AbstractEuropean Governments must implement a public alerting system to reach mobile phone users affected by major emergencies and disasters by June 2022. Cell Broadcast is used to issue emergency alerts in several countries but has not yet been introduced in the UK. This paper presents the results of a joint research exercise that explored recipients’ responses to cell broadcast messages that warned of floods of varying certainty, severity, and urgency. We adopted a mixed-methods approach employing semi-structured questions and focus groups to assess the perceptions of 80 workshop participants who received simulated emergency alerts on pre-prepared handsets. Our results suggest that although emergency alerting is welcomed, it is necessary to provide accurate and verifiable information, address accessibility challenges, and state location clearly and understandably. This life-saving technology, if used aptly by not over-alerting, specifying the specific urgency, certainty, severity and location of the flood risk, has the real potential of upgrading flood warnings in the UK.
Performance of signal detection with trellis code for downlink non-orthogonal multiple access visible light communication
Authors: Astharini Dwi , Asvial Muhamad , Gunawan Dadang 
Published: February 2022

AbstractThis paper examines the implementation of multi-level amplitude modulation enforced by trellis coding in a downlink non-orthogonal multiple access channel for visible light communication (VLC). The non-orthogonal transmission is applied using superposition coding and successive interference cancellation with the support of a trellis decoder. The VLC is addressed by a channel model according to Lambert. Two levels of maximum likelihood signal detection are observed and compared, each for corresponding 4 and 8 trellis-coded modulation (TCM). The power ratio allotment is examined to investigate the system performance in the bit error rate. The simulation showed that a threshold of power ratio is needed to ensure good performance of signal detection. Further simulation with successive detection had shown effective results for up to three users.
Tableaux for Logics of Content Relationship and Set-Assignment Semantics
Authors: Jarmużek Tomasz , Klonowski Mateusz 
Published: February 2022

AbstractIn the paper, we examine tableau systems for R. Epstein’s logics of content relationship: $$\mathbf {D}$$
D
(Dependence Logic), $$\mathbf {DD}$$
DD
(Dual Dependence Logic), $$\mathbf {Eq}$$
Eq
(Logic of Equality of Content), $$\mathbf {S}$$
S
(Symmetric Relatedness Logic) and $$\mathbf {R}$$
R
(Nonsymmetric Relatedness Logic) (Epstein in The semantic foundations of Logic, Springer Science + Business Media, Dordrecht, (1990), cf. Epstein in Philos Stud 36:137–173, 1979, Epstein in Rep. Math. Logic 21:19–34, 1987, Klonowski in Logic Log Philos, accepted for publication, Krajewski in J Non Class Logic 8:7–33, 1991). The first tableau systems for those logics were defined by Carnielli (Rep Math Logic 21:35–46, 1987). However, his approach has some limitations, for example, it requires a proof of functional completeness and axiomatization. Notwithstanding the first two constraints, it does not include all Epstein logics, e.g., logic $$\mathbf {Eq}$$
Eq
. Unlike Carnielli’s approach, here we use set-assignment semantics to determine those logics. Since syntax and semantics of a given logic usually determine a minimal syntax and structure of a tableau system for the logic along with other properties, we propose a uniform tableau framework for the logics determined by set-assignment semantics. What distinguishes our tableau systems is that they combine the features of tableaux for propositional logics and syllogistic logics when the problem of content of propositions is analysed in tableau proofs. To denote the content of propositions in the proofs, we use generalised labels (explored in the syllogistic context in Jarmużek and Goré (In: Fitting (ed.) Landscapes in Logic, College Publications, London, accepted)).
Is ~ K ~ KP a luminous condition?
Authors: Smith Martin 
Published: February 2022

Abstract
One of the most intriguing claims in Sven Rosenkranz’s Justification as Ignorance is that Timothy Williamson’s celebrated anti-luminosity argument can be resisted when it comes to the condition ~ K ~ KP—the condition that one is in no position to know that one is in no position to know P (for some proposition P). In this paper, I critically assess this claim.
Stressed out: the effects of heat stress and parasitism on gene expression of the lichen-forming fungus Lobaria pulmonaria
Authors: Kraft Miriam , Scheidegger Christoph , Werth Silke 
Published: February 2022

AbstractGene expression variation can be partitioned into different components (regulatory, genetic and acclimatory effects) but for lichen-forming fungi, the relative importance of each of these effects is unclear. Here, we studied gene expression in the lichen-forming fungus Lobaria pulmonaria in response to thermal stress and parasitism by the lichenicolous fungus Plectocarpon lichenum. Our experimental procedure was to acclimate lichen thalli to 4 °C over three weeks and then expose them to 15 °C and 25 °C for 2 hours each, sampling infected and visually asymptomatic thalli at each temperature. Quantitative Real-Time PCR was utilized to quantify gene expression of six candidate genes, normalizing expression values with two reference genes. We found that two genes encoding heat shock proteins (hsp88 and hsp98), two polyketide synthase genes (rPKS1, nrPKS3) and elongation factor 1-1-α (efa) were upregulated at higher temperatures. Moreover, we observed higher expression of hsp98 at 25 °C in samples infected by P. lichenum than in uninfected samples. Finally, in partial redundancy analyses, most of the explained variation in gene expression was related to temperature treatment; genetic variation and long-term acclimatization to sites contributed far less. Hence, regulatory effects (i.e. direct adjustments of gene expression in response to the temperature change) dominated over genetic and acclimatory effects in the gene expression variability of L. pulmonaria. This study suggests that L. pulmonaria could become a valuable lichen model for studying heat shock protein responses in vivo.