bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of gender perspective in the use of NANDA‐I nursing diagnoses: A systematic review
Authors: Rifà‐Ros Mª Rosa , Rodríguez‐Monforte Míriam , Carrillo‐Alvarez Elena , Silva Luana Barreto‐Da , Pallarés‐Marti Angela , Gasch‐Gallen Angel 
Published: November 2022

AbstractAimTo identify, describe and analyse the gender perspective in the use of the diagnoses contained in the NANDA‐I taxonomy in observational studies published in the scientific literature.Design and methodsA systematic review has been conducted spanning from 2002 to 2020. The most frequent NANDA‐I nursing diagnoses in care plans reported in observational studies, and the defining characteristics and related factors identified for men and women have been described. The Preferred Reporting Items for Systematic Reviews (PRISMA‐P) have guided our research.The main findings have been summarized using a descriptive narrative synthesis approach.ResultsForty‐one articles were included in our study. With regard to gender analysis, the percentage of men and women that make up the sample were not specified in all articles, and half of the studies did not identify gender either in the diagnosis label or in their defining characteristics or related factors.Based on the reviewed articles, gender perspectives are not systematically incorporated in the use of the NANDA‐I diagnosis. Therefore, gender biases in its use in the scientific literature may exist. This situation poses barriers to determine the health responses that are different and unequal between women and men.
Development of an evidence‐based care bundle protocol for preventing falls in hospitalized children: Delphi study and trial test
Authors: Chen Lixia , Liu Wenjing , Li Hong 
Published: November 2022

AbstractAimThe aim of the study was to develop an evidence‐based care bundle protocol for preventing falls in hospitalized children.DesignDelphi method.MethodsBased on the four basic concepts of nursing, the theoretical dimension and item pool of the care bundle first draft were constructed by searching evidence and referring to the care bundle for preventing inpatient fall issues by the China Nursing Quality Promotion Alliance. The Delphi method and trial tests were used to select and adjust items of the care bundle to form the care bundle protocol for preventing falls in hospitalized children.ResultsThe first draft care bundle for preventing falls in hospitalized children included 4 dimensions and 21 items. In the 2‐round Delphi study, one item was removed, and three items were adjusted. One item was adjusted by trial test. Finally, the care bundle protocol for preventing falls in hospitalized children consisted of 4 dimensions and 20 items.
Risk assessment of accidental falls in patients taking trazodone, quetiapine, or risperidone for insomnia: A single‐center, case–control study
Authors: Shimizu Yoshihito , Taga Masatoshi , Takahashi Yoshimitsu , Yamamoto Yasuhiko , Masauji Togen 
Published: November 2022

AbstractAimNo consensus has been reached on the association between the risk of falls and antipsychotic and antidepressant drug use. In this study, we evaluated the risk of falls with trazodone, risperidone, and quetiapine, which are recommended for use at Kanazawa Medical University Hospital.MethodsWe reviewed all patients who were admitted to Kanazawa Medical University Hospital between January 1st and December 31st, 2018. We excluded those aged <20 years and those admitted to pediatric, intensive care, and psychiatric wards. Finally, 9273 patients were included. We reviewed the incidence in these patients of accidental falls reported to the medical safety department. We noted whether these patients received trazodone, quetiapine, or risperidone. We also observed whether they were taking a benzodiazepine receptor agonist, which is a known risk factor. We further examined each patient's age, sex, the department they were visiting, and their diseases. Patients were considered to have taken medication if it was administered within 24 hours before an accidental fall. Multiple logistic regression analysis was used to evaluate the risk of accidental fall.ResultsMultivariate analysis showed that the adjusted odds ratios (OR) for each medication (with 95% confidence intervals) were: trazodone (OR, 0.47 [0.27–0.80]), quetiapine (OR, 1.06 [0.46–2.46]), and risperidone (OR, 0.82 [0.41–1.63]).ConclusionThe association of risperidone and quetiapine with accidental falls was unclear. Interestingly, however, trazodone may help reduce the risk, which makes it a potential pharmacologic treatment option for insomnia in patients at high risk for accidental falls.
p38α in the preoptic area inhibits brown adipose tissue thermogenesis
Authors: Wang Jing , Wu Shanshan , Zhan Huidong , Bi Wenkai , Xu Yang , Liang Yixiao , Ge Yueping , Peng Li , Jin Xinchen , Lu Keke , Zhao Jiajun , Gao Ling , He Zhao 
Published: November 2022

AbstractObjectiveElevation of energy expenditure through an increase of brown adipose tissue (BAT) thermogenesis is regarded as one of the most promising ways to prevent obesity development. The preoptic area (POA) of the hypothalamus is a critical area for control of BAT thermogenesis. However, the intracellular signaling cascades in the POA for regulation of BAT thermogenesis are poorly understood.MethodsPhosphorylation proteomics (phosphoproteomics) and bioinformatics approaches were used to disclose numerous hypothalamic signaling pathways involved in the regulation of BAT thermogenesis. Conditional manipulation of the p38α gene in mouse POA was performed by stereotaxic injection of adeno‐associated virus 9 vector to explore the role of p38α in BAT thermogenesis.ResultsMultiple hypothalamic signaling pathways were triggered by cold exposure, especially the mitogen‐activated protein kinase (MAPK) signaling pathway. The p38α activation, but not extracellular signal‐regulated kinase 1/2 (ERK1/2) and c‐Jun NH2‐terminal kinase (JNK), in the hypothalamus was significantly decreased during cold exposure. p38α deficiency in the POA dramatically elevated energy expenditure owing to a marked increase in BAT thermogenesis, resulting in significantly decreased body weight gain and fat mass. Overexpression of p38α in the POA led to a dramatic increase in weight gain.ConclusionsThese results demonstrate that p38α in the POA exacerbates obesity development, at least in part owing to a decrease in BAT thermogenesis.
Macronutrient (im)balance drives energy intake in an obesogenic food environment: An ecological analysis
Authors: Grech Amanda , Sui Zhixian , Rangan Anna , Simpson Stephen J. , Coogan Sean C. P. , Raubenheimer David 
Published: November 2022

AbstractObjectiveThe protein leverage hypothesis (PLH) postulates that strong regulation of protein intake drives energy overconsumption and obesity when human diets are diluted by fat and carbohydrates. The two predictions of the PLH are that humans (i) regulate intake to maintain protein within a narrow range and that (ii) energy intake is an inverse function of percentage energy from protein because absolute protein intake is maintained within narrow limits.MethodsMultidimensional nutritional geometry was used to test the predictions of the PLH using dietary data from the Australian National Nutrition and Physical Activity Survey.ResultsBoth predictions of the PLH were confirmed in a population setting: the mean protein intake was 18.4%, and energy intake decreased with increasing energy from protein (L = −0.18, p < 0.0001). It was demonstrated that highly processed discretionary foods are a significant diluent of protein and associated with increased energy but not increased protein intake.ConclusionsThese results support an integrated ecological and mechanistic explanation for obesity, in which low‐protein highly processed foods lead to higher energy intake because of the biological response to macronutrient imbalance driven by a dominant appetite for protein. This study supports a central role for protein in the obesity epidemic, with significant implications for global health.
The basis and design for time‐restricted eating compared with daily calorie restriction for weight loss and colorectal cancer risk reduction trial (TRE‐CRC trial)
Authors: Gabel Kelsey , Fitzgibbon Marian L. , Yazici Cemal , Gann Peter , Sverdlov Maria , Guzman Grace , Chen Zhengjia , McLeod Andrew , Hamm Alyshia , Varady Krista A. , Tussing‐Humphreys Lisa 
Published: November 2022

AbstractObjectiveApproximately 42% of American adults are living with obesity, increasing their risk of colorectal cancer (CRC). Efficacious approaches to prevent and treat obesity may reduce CRC incidence. Daily calorie restriction (Cal‐R) is the most common approach to treating obesity, yet clinically meaningful weight loss is elusive owing to waning adherence. Time‐restricted eating (TRE) consists of consuming foods within a specified time frame, creating a natural calorie deficit. TRE in animals shows cancer protective effects. In humans, TRE is safe and acceptable among adults with obesity, producing ~3% to 5% weight loss and reductions in oxidative stress and insulin resistance. However, TRE has not been tested rigorously for CRC preventive effects.MethodsThe authors describe a 12‐month randomized controlled trial of 8‐hour TRE (ad libitum 12 PM‐8 PM), Cal‐R (25% restriction daily), or Control among 255 adults at increased risk for CRC and with obesity.ResultsEffects on the following will be examined: 1) body weight, body composition, and adherence; 2) circulating metabolic, inflammation, and oxidative stress biomarkers; 3) colonic mucosal gene expression profiles and tissue microenvironment; and 4) maintenance of benefits on body weight/composition and CRC risk markers.ConclusionsThis study will examine efficacious lifestyle strategies to treat obesity and reduce CRC risk among individuals with obesity.
Thermo‐oxidative degradation of ultrahigh molecular weight poly(ethylene oxide) in volatile organic solvents
Authors: Bai Shishun , Chen Kuo , Huang Wei , Wang Peng , Chen Xun , Chen Peng 
Published: November 2022

AbstractThe degradation of ultrahigh molecular weight poly(ethylene oxide) (UHMWPEO) was investigated in three volatile organic solvents, methanol, chloroform, and tetrahydrofuran. Particularly, degradation rate was determined by means of Ubbelohde viscometry and degradation products were characterized by using electron spin resonance spectroscopy (ESR) and Fourier transform infrared spectroscopy (FTIR). The highest degradation rate was observed for UHMWPEO in tetrahydrofuran, with the lowest one in methanol. The ESR results showed that PEO‐C• and •OH radicals were produced during the degradation process. Among these selected solvents, tetrahydrofuran was found to generate free radicals through an autoxidation mechanism. This would accelerate the degradation of UHMWPEO, resulting in the observed highest degradation rate in the UHMWPEO/tetrahydrofuran solution. Esters were also detected in the degradation products of these UHMWPEO solutions, while formates and formate ions were generated in the solutions of UHMWPEO/tetrahydrofuran and UHMWPEO/cloroform except for PEO/methanol. Furthermore, the degradation mechanism of UHMWPEO was deduced. This work enabled an in‐depth understanding on the thermo‐oxidative degradation mechanism of UHMWPEO in representative organic solvents, which would be instructive for developing optimal solution‐based processing technique of UHMWPEO.
Antibacterial activity of natural polymer gels and potential applications without synthetic antibiotics
Authors: Hamidi Samin , Monajjemzadeh Farnaz , Siahi‐Shadbad Mohammadreza , Khatibi Seyed Amin , Farjami Afsaneh 
Published: November 2022

AbstractAntibiotics' use has increased, resulting in disadvantages like patients' drug resistance. Consequently, urgent action is required to develop a new generation of antibacterial agents. Most antibacterial platforms still require a modification with further antibacterial agents (e.g., antibiotics) for adequate antibacterial efficiency. Thus, a nonantibiotic methodology is immediately needed. Furthermore, bactericidal agents used for this purpose are usually based on metal nanoparticles, carbon materials, and polymers. Still, chemicals, antibiotics, and biocides lead to environmental damage. Therefore, the help of biocompatible yet durable materials and polymers is highly appreciated. In addition, if a polymer is not biodegradable, it will remain in the environment for more than one hundred years due to its low degradation rate. Moreover, non‐biodegradable polymers are harmful to in vivo applications. Hence, the use of biodegradable and non‐toxic materials has received many considerations. Over the last few years, the design and synthesis of new polymer gels have gained increasing attention. A polymer gel, also known as a hydrogel, is a three‐dimensional and cross‐linked network filled with water or other liquid solvents. Besides, the hydrogels supercritical drying method results in aerogels, and the freeze‐drying method generates cryogels, where their porous and sponge‐like structures are preserved. Additionally, antibacterial polymer gels are a new generation of polymers considered attractive due to their unique properties. The most recent studies and the latest innovations in polymer gels and hybrid polymers with intrinsic antibacterial properties were discussed in the present review. The reviewed studies from 2015 to April 2022 showed a tremendous revival in research about biopolymer hydrogel, aerogel, and cryogel as antibacterial agents.
Individual ignition of RF microplasma array at atmospheric pressure
Authors: Martinet David , Filliger Sebastian , Germanier Alain , Gugler Gilbert , Ellert Christoph 
Published: November 2022

AbstractFollowing the trend of miniaturization in semiconductor industry, atmospheric plasma jets in array configuration were developed for cleaning or treatment of workpieces under homogeneous conditions. We describe here first, the development of a small array of five individual identical plasma cells where each cell is ignited and quenched individually, which can be upscaled to several tens or hundreds of cells. The power electronics for ignition of plasma is composed of a multiplexing system with a kHz high‐voltage plasma ignition pulse and an RF‐supply that can be distributed to each ignited cell to maintain the plasma in the respective cell. Experimental results show an ignition voltage for argon of 1300 V and RF‐current per cell of 70 mA.
PredictingDNA‐binding protein and coronavirus protein flexibility using protein dihedral angle and sequence feature
Authors: Wang Wei , Su Xili , Liu Dong , Zhang Hongjun , Wang Xianfang , Zhou Yun 
Published: November 2022

AbstractThe flexibility of protein structure is related to various biological processes, such as molecular recognition, allosteric regulation, catalytic activity, and protein stability. At the molecular level, protein dynamics and flexibility are important factors to understand protein function. DNA‐binding proteins and Coronavirus proteins are of great concern and relatively unique proteins. However, exploring the flexibility of DNA‐binding proteins and Coronavirus proteins through experiments or calculations is a difficult process. Since protein dihedral rotational motion can be used to predict protein structural changes, it provides key information about protein local conformation. Therefore, this paper introduces a method to improve the accuracy of protein flexibility prediction, DihProFle (Prediction of DNA‐binding proteins and Coronavirus proteins flexibility introduces the calculated dihedral Angle information). Based on protein dihedral Angle information, protein evolution information, and amino acid physical and chemical properties, DihProFle realizes the prediction of protein flexibility in two cases on DNA‐binding proteins and Coronavirus proteins, and assigns flexibility class to each protein sequence position. In this study, compared with the flexible prediction using sequence evolution information, and physicochemical properties of amino acids, the flexible prediction accuracy based on protein dihedral Angle information, sequence evolution information and physicochemical properties of amino acids improved by 2.2% and 3.1% in the nonstrict and strict conditions, respectively. And DihProFle achieves better performance than previous methods for protein flexibility analysis. In addition, we further analyzed the correlation of amino acid properties and protein dihedral angles with residues flexibility. The results show that the charged hydrophilic residues have higher proportion in the flexible region, and the rigid region tends to be in the angular range of the protein dihedral angle (such as the ψ angle of amino acid residues is more flexible than rigid in the range of 91°–120°). Therefore, the results indicate that hydrophilic residues and protein dihedral angle information play an important role in protein flexibility.
The trend and future projection of technology‐assisted total knee arthroplasty in the United States
Authors: Lan Yu‐Tung , Chen Ya‐Wen , Niu Ruijia , Chang David C. , Hollenbeck Brian L. , Mattingly David A. , Smith Eric L. , Talmo Carl T. 
Published: November 2022

AbstractBackgroundAs technology‐assisted surgery has boosted in the last decades, we aimed to investigate the factors affecting adoption and to predict the future utilization of technology among patients who underwent total knee arthroplasty (TKA).MethodsPatients underwent TKA in 2017–2019 in the MarketScan Database were included. Percentage of technology‐assisted surgery was calculated. Multivariable logistic regression models were performed to analyse the factors and make the prediction.ResultsOf 112,161 TKA procedures, 7.2% were technology‐assisted. The proportion of technology‐assisted TKA is expected to reach 50% by 2032. The West showed the highest proportion of technology‐assisted TKA (12.3%), while the South had the lowest (5.7%). Over time, the Midwest showed the greatest increase in technology adoption (OR = 1.26 compared to the Northeast, 95% CI [1.15, 1.38]).ConclusionsTechnology adoption rate of TKA will continue to increase for the next 20 years in the United States with a slight geographical variation.
A theory of missed external enablement
Authors: Wood Matthew S. , Williams David W. , Drover Will 
Published: November 2022

AbstractResearch SummaryThis article introduces the concept of missed external enablement as a choice not to act on significant change in the business environment that later proves to be a meaningful accelerant for an entrepreneurial endeavor. There has been little consideration to date of such errors of omission. In response, we model the opacity and the agent intensity of enablement as fuel for inaction, leading to missed enablement. We then specify factors, such as magnitude of the miss, that strengthen or weaken the effect. As this unfolds, entrepreneurs consider how to best respond, and we model various response paths that may increase or decrease subsequent entrepreneurial action, where the path is again influenced by opacity and agent intensity. The theory generated exposes new facets of external enablement.Managerial SummaryThe effects of external change are shrouded in opacity. It is therefore difficult for entrepreneurs to discern whether change benefits one's endeavor and if it does, whether the effort, time, and resources are available to capitalize on it. Hence, it is rather easy to mistakenly choose entrepreneurial inaction. Our theory addresses the complexity and richness of these dynamics as they lead to missed external enablement, and our model outlines specific ways entrepreneurs might respond when they miss out on the benefits of external change. The insights we generate highlight the effects of entrepreneurs' exposure to many changes in the business environment over time, where the actions of others coupled with one's own past interpretations of the meaning of external changes influence what follows.
Religion, homosexuality, and the EU: Grasping the beliefs of Romanian Orthodox priests
Authors: Miscoiu Sergiu , Gherghina Sergiu , Samsudean Dragos 
Published: November 2022

AbstractThe European Union and the Church often have contrasting positions toward the rights, freedoms, and status of sexual minorities. Earlier research illustrates that the Church opposes the EU as a promoter of homosexuality and brings a critique based on national identity. In spite of these debates, we know very little about how the priests perceive the relationship between homosexuality and the EU. The priests' beliefs and opinions can provide insights into what is beyond the official Church statements. This article seeks to address that gap in the literature and analyzes the ways in which the Romanian Orthodox priests link the EU and the topic of homosexuality. Our qualitative study uses inductive thematic analysis and draws on 18 semi‐structured interviews conducted with priests in December 2020–February 2021. The findings indicate the existence of three main points of criticism against what the respondents perceive as an increasing pressure by the EU to adopt a favorable treatment of homosexuals.
Acrylonitrile Adducts: An Efficient Adsorbent Media for Removal of Iron from Water
Authors: Das Parineeta , Dutta Dhiraj , Sarkar Ankita , Dubey Rama , Puzari Amrit 
Published: November 2022

AbstractPresent study establishes a series of acrylonitrile adducts as an effective adsorption media for removal of ferrous ion from water. Adduct synthesis was carried out following aza‐Michael addition reaction between primary aliphatic amines and acrylonitrile under mild conditions. The synthesized products were characterised by FT‐IR, ESI‐MS and 1H NMR spectroscopy and the particle size was analysed by DLS measurements. Adsorption isotherm study of the adducts showed prominent results. The positively charged iron ion interacts with negatively charged acrylonitrile adducts and forms a bulky structure which precipitates out from water. The most interesting feature of these compounds is its electron rich property which facilitates effective interaction with the positively charged iron ions present in water and thus imparting high adsorption capacity. Batch experiments were performed to figure out the best adsorption conditions. These studies were used to investigate the effects of various viable characteristics such as initial metal ion concentration, pH and contact time. The adsorption isotherm was well fitted by Langmuir model. The maximum adsorption capacity of acrylonitrile adducts for iron was recorded as 22.65 mg/g.
Advances in 2D Molybdenum Disulfide‐Based Functional Materials for Supercapacitor Applications
Authors: R. Rohith. , Prasannakumar Anandhu Thejas , Mohan Ranjini R. , V. Manju. , Varma Sreekanth J. 
Published: November 2022

AbstractEnergy storage has become the most crucial topic of research in the 21st century owing to the growing demand for energy for various modern‐day requirements. Supercapacitors (SCs) are energy storage devices that can deliver power for a wide range of electronic gadgets, electric/hybrid vehicles and sophisticated machines used in space and the military. Electrode materials play a vital role in determining the electrochemical performance and stability of these energy devices. It is therefore essential to design efficient and long‐lasting materials that are solid, lightweight and flexible to suit various applications. The excellent chemical and physical properties of MoS2 have made it one of the most widely considered two‐dimensional nanomaterials in the past few years. Through this review, we mainly highlight the synthesis, properties, and electrochemical performance of MoS2 and its composites‐based functional materials. The potential uses of MoS2 in various fields imply that this material still offers many possibilities for exploration and development.