bluuebunny/crossref_metadata_2025_split huggingface dataset:
An extended reservoir of class-D beta-lactamases in non-clinical bacterial strains
Authors: Lupo Valérian , Mercuri Paola Sandra , Frère Jean-Marie , Joris Bernard , Galleni Moreno , Baurain Denis , Kerff Frédéric 
Published: January 2022

AbstractBacterial genes coding for antibiotic resistance represent a major issue in the fight against bacterial pathogens. Among those, genes encoding beta-lactamases target penicillin and related compounds such as carbapenems, which are critical for human health. Beta-lactamases are classified into classes A, B, C and D, based on their amino acid sequence. Class D enzymes are also known as OXA beta-lactamases, due to the ability of the first enzymes described in this class to hydrolyze oxacillin. While hundreds of class D beta-lactamases with different activity profiles have been isolated from clinical strains, their nomenclature remains very uninformative. In this work, we have carried out a comprehensive survey of a reference database of 80,490 genomes and identified 24,916 OXA-domain containing proteins. These were deduplicated and their representative sequences clustered into 45 non-singleton groups derived from a phylogenetic tree of 1413 OXA-domain sequences, including five clusters that include the C-terminal domain of the BlaR membrane receptors. Interestingly, 801 known class D beta-lactamases fell into only 18 clusters. To probe the unknown diversity of the class, we selected ten protein sequences in ten uncharacterized clusters and studied the activity profile of the corresponding enzymes. A beta-lactamase activity could be detected for seven of them. Three enzymes were active against oxacillin and two against imipenem. These results indicate that, as already reported, environmental bacteria constitute a large reservoir of resistance genes that can be transferred to clinical strains, whether through plasmid exchange or hitchhiking with the help of transposase genes.ImportanceThe transmission of genes coding for resistance factors from environmental to nosocomial strains is a major component in the development of bacterial resistance towards antibiotics. Our survey of class D beta-lactamase genes in genomic databases highlighted the high sequence diversity of the enzymes that are able to recognize and/or hydrolyze beta-lactam antibiotics. Among those, we could also identify new beta-lactamases that are able to hydrolyze carbapenems, one of the last resort antibiotic families used in human chemotherapy. Therefore, it can be expected that the use of this antibiotic family will fuel the emergence of new beta-lactamases into clinically relevant strains.
A bibliometric study on library and information science and information systems literature during 2010–2019
Authors: Wijewickrema Manjula 
Published: January 2022

PurposeStudying the nature of research progress in interrelated research domains is important for evaluating the research productivity and to understand the current trends of the area of research. This study aims to examine a research domain that combines library and information science with information systems (IS).Design/methodology/approachQuartile 1 journals that cover both subject domains in SCImago were selected for the study. Bibliographic records of the publications during 2010 and 2019 were retrieved from the Scopus database. VOSviewer data visualization tool was used to perform citation, coauthorship, bibliographic coupling, cocitation and co-occurrence analysis. In addition, descriptive and inferential statistics were exploited.FindingsThe absence of a consistent association between the number of documents authored and the number of citations received by a researcher was an important finding of the study. The strong association of authors regardless of the different topics they researched and the trend of increasing interest on collaborative research were also highlighted. Moreover, the authors who received the highest number of citations were not always the first authors of the documents which received the most citations. The documents published in information management, information theory and IS journals attained the most citations. The journals, institutions and countries with the highest number of documents and citations were also revealed by the research. Electrical engineering departments showed a higher research productivity, while they were utilized more compared to that of other departments. IS and management, information theory, communication, information retrieval, geographic-based IS and bioinformatics were the six major research areas of the considered domain.Originality/valueThis is the first study related to examining the research progress in a combined subject domain using multiple aspects including, individual performance, institutional progress, geographical contribution and so on. Identifying the major research areas in the combined subject domain can also be considered a novel contribution to the field.
Optimization of fleet structure and investment evaluation – the cargo owner's fleet perspective
Authors: Jin Zhihong , Wang Xiaohan , Sun Jiaqing , Xu Qi 
Published: January 2022

PurposeEnergy groups are cargo owners with large amounts of energy sources (such as coal) to transport. To achieve a satisfactory tradeoff between the reliability requirements of the sea transportation process and the need to control the investment cost, they usually set up a self-owned fleet supplemented by a chartered fleet. This paper aims to investigate the best fleet structure and to evaluate the investment scheme under volatile circumstances in the shipping market.Design/methodology/approachThe authors construct a mathematical model to determine the ratio of the self-owned fleet to the total fleet to minimize fleet operating costs. The volatility of both freight rates and oil prices is taken into consideration. The CPLEX solver is used to empirically analyze real data from an energy group in China, and the ship investment plan is evaluated considering the technical and economic feasibility.FindingsIf the ratio of the self-owned fleet to the total fleet is increased to the optimal of 90.40%, the total operating cost is reduced by 33.98%. Thus, the energy group should increase its capacity with a Panamax vessel of approximately 82,000 DWT. Purchasing a 5-year-old secondhand ship and building a new ship both have good investment return indicators.Originality/valueFor cargo owners engaging in transporting bulk cargo domestically in China, the suggested fleet ratio can provide a reference with a universal application scale, given the boundary economic conditions (including the volatility of freight rates and oil prices in the shipping market) in the paper.
3D high‐order sparse radon transform with L1–2 minimization for multiple attenuation
Authors: Geng Weiheng , Li Jingye , Chen Xiaohong , Ma Jitao , Xu Jiamin , Zhu Guang , Tang Wei 
Published: January 2022

ABSTRACTAmong many multiple attenuation methods, parabolic Radon transform has been widely used due to its efficiency and effectiveness. However, there are two factors that restrict the application of Radon transform: (1) the smearing caused by finite seismic acquisition aperture and discrete sampling of seismic data and (2) the destruction of the amplitude versus offset signature in seismic data. Therefore, a high‐order sparse Radon transform in the mixed frequency–time domain with L1–2 minimization is proposed. The L1–2 metric has been proved an unbiased approximation to L0 norm, which helps improve the sparsity and resolution of the Radon model. By combining the orthogonal polynomial transform, which can fit the amplitude variations of seismic data, the amplitude versus offset signature is also considered. Furthermore, the 2D Radon transform is extended to 3D by modifying the augmented Lagrangian in the alternating direction method of multipliers algorithm. Compared with the 2D algorithm, 3D Radon transform considers seismic wave propagation in three dimensions, which can describe the wavefield more accurately. The proposed method is applied to multiple attenuation examples based on both synthetic and real 3D data examples to demonstrate its effectiveness, compared with some existing high‐resolution techniques and the corresponding 2D algorithm.
A dual mechanism fully blocks ethanol relapse: Role of vagal innervation
Authors: Quintanilla María Elena , Ezquer Fernando , Morales Paola , Santapau Daniela , Ezquer Marcelo , Herrera‐Marschitz Mario , Israel Yedy 
Published: January 2022

AbstractPrevious studies showed that vagotomy markedly inhibits alcohol self‐administration. Present studies hypothesised that vagotomy significantly adds to the inhibition of alcohol relapse induced by drugs that reduce the alcohol‐induced hyperglutamatergic state (e.g., N‐acetylcysteine + acetylsalicylic acid). The alcohol relapse paradigm tested gauges the elevated alcohol intake observed in animals that had consumed ethanol chronically, were subjected to a prolonged alcohol deprivation and are subsequently allowed ethanol re‐access. Ethanol‐drinker rats (UChB) were exposed to 10% and 20% ethanol and water concurrently for 4 months, were alcohol deprived for 14 days and were thereafter allowed re‐access to the ethanol solutions. An initial binge‐like drinking episode is observed upon ethanol re‐access, followed by a protracted elevated ethanol intake that exceeds the predeprivation intake baseline. Prior to ethanol re‐access, animals were (i) administered N‐acetylcysteine (40 mg/kg/day) + acetylsalicylic acid (15 mg/kg/day), (ii) were bilaterally vagotomised, (iii) were exposed to both treatments or (iv) received no treatments. The initial binge‐like relapse intake and a protracted elevated ethanol intake observed after repeated ethanol deprivations/re‐access cycles were inhibited by 50%–70% by the administration of N‐acetylcysteine + acetylsalicylic acid and by 40%–70% by vagotomy, while the combined vagotomy plus N‐acetylcysteine + acetylsalicylic acid treatment inhibited both the initial binge‐like intake and the protracted ethanol intake by >95% (p < 0.001), disclosing a dual mechanism of ethanol relapse and subsequent inhibition beyond that induced by either treatment alone. Future exploration into the mechanism by which vagal activity contributes to ethanol relapse may have translational promise.
Pipeline capacity and the dynamics of Alberta crude oil price spreads
Authors: Galay Gregory , Thille Henry 
Published: January 2022

AbstractWe investigate the effect of binding pipeline capacity on price spreads between crude oil in Alberta, Canada, and competing crude oils in export markets at the other end of the pipeline. Our goal is to determine whether these price spreads are consistent with capacity‐constrained spatial arbitrage models by estimating Markov switching models of the price spreads for both heavy and light crude oil. Our results for heavy crude oil agree with the theory: we find one regime with both a low mean and a low variance, consistent with sufficient pipeline capacity, and another regime with both a higher mean and a higher variance, consistent with constrained pipeline capacity. The difference in mean spreads between regimes then provides an estimate of the mean shadow price of capacity. Price spreads for light crude oil do not display significant differences in mean spreads across regimes, suggesting that pipeline capacity constraints are less important for this commodity. Comparing our results with pipeline capacity data, we find that tight capacity is not always associated with large price spreads.
Femtosecond laser‐assisted minimally invasive lamellar keratoplasty for the treatment of advanced keratoconus
Authors: Gao Hua , Liu Mingna , Li Na , Chen Tong , Qi Xiaolin , Xie Lixin , Shi Weiyun 
Published: January 2022

AbstractBackgroundTo evaluate the initial safety and efficacy of femtosecond laser‐assisted minimal invasive lamellar keratoplasty (FL‐MILK) for advanced keratoconus.MethodsTwenty‐two patients (22 eyes) with advanced keratoconus were included in this prospective study. All the involved eyes underwent FL‐MILK. The femtosecond laser was used to create an intrastromal pocket with a 2.3 mm incision in the recipient cornea. Then a stromal button with a diameter of 9.0 mm and a depth of 200 μm was gently inserted into the intrastromal pocket through the 2.3 mm incision and flattened. No sutures were applied. Follow‐up was conducted for 24 months.ResultsTwenty‐two patients completed follow‐up data for 12 months, 16 patients had 24 months follow‐up. No epithelial implantation, infection or allogeneic rejection were observed during the follow‐up. Based on baseline values, postoperative 12 months values and postoperative 24 months values, clinical significantly improvement was recorded in corrected distance visual acuity (CDVA) (0.40 ± 0.18 logMAR vs. 0.30 ± 0.12 logMAR and 0.23 ± 0.13 logMAR), the anterior central corneal elevation (29.14 ± 15.33 μm vs. 14.45 ± 13.75μm and 11.38 ± 8.33 μm), and corneal higher‐order aberrations (3.536 ± 1.503 vs. 2.761 ± 1.517 and 0.994 ± 0.391). Corneal biomechanical properties in all eyes improved significantly. SP‐A1 increased from 48.64 ± 12.87 preoperatively to 87.26 ± 21.01 postoperative 12 months and 88.77 ± 18.26 postoperative 24 months; deformation amplitude (DA) decreased from 1.36 ± 0.15 preoperatively to 1.21 ± 0.12 postoperative 12 months and 1.19 ± 0.19 postoperative 24 months.ConclusionsInitial experience suggests that this minimally invasive transplantation may be a feasible option for advanced keratoconus. A larger cohort and longer follow‐up are required to validate our results and establish long‐term safety and efficacy of the procedure.
Forced Migration and Forced Disjunctions: An Exploration of Imagination's Role in Changing Long‐Standing Cultural Identity and Lifeways
Authors: Chrostowsky MaryBeth 
Published: January 2022

AbstractIn this article, I show how attention to cognitive processes such as imagination can help anthropology better understand the contextual factors that influence change in long‐standing cultural identity and lifeways. Using data from a 14‐month ethnographic study among returned male Dinka Bor of Southern Sudan, I illustrate how imagination allows a forced migrant to explore alternatives, including possibilities that were previously unknown, or even thought to be impossible, before displacement. As forced migrants in my study adapted to their new environment, including major disruptions to their political, cultural, and gendered world, certain events, experiences, and scenarios were more cognitively available. These salient and easily available contextual factors are influential not only in short‐term solutions but also in the reconstruction of identity and imagined futures. This empirical case shows a pattern among some male Dinka Bor forced migrants who appear to subscribe to a newly developing Dinkahood that includes an understood urbane lifestyle and an imagined future that differs from customary Dinka Bor identity and lifeways.
Establishing tourism sustainability in a globally important agricultural heritage system in China: A case of social and eco‐system recovery
Authors: Fuller Anthony M. , Bao Jigang , Liu Yi , Zhou Xiaoyi 
Published: January 2022

AbstractThis paper in the form of a narrative, contributes an account of revitalizing sustainability of a World Heritage site—the Hani rice‐fish terrace system—in a pristine area of cultural and ecological significance in Southwest China. Rice‐fish farming in mountain terraces is an ingenious system that has existed in various forms for hundreds of years. However, due to international recognition by FAO and UNESCO of this area as a world agricultural heritage site, the system was threatened of losing its eco‐social balance because of mass tourism overload. Remarkably, after a period of development chaos and because of changing actors and roles, a semblance of sustainability has been regained through firm protection and management of the chief tourism asset—the rice terraces. Utilising a stakeholder approach to form multiple narratives, our research reveals the interplay of government, private enterprise, Hani people and outside experts in reshaping the trajectory of tourism development when the world‐heritage attractiveness brings new threats to the ecological systems and turned the destination into a challenging geographical environment. It demonstrates the need for strong and inclusive management techniques some of which have now been applied in the core Hani area, with appreciable success.
Influence of blood group and von Willebrand factor on population pharmacokinetics and dose individualization of recombinant factor VIII in Taiwanese patients with haemophilia A
Authors: Singkham Noppaket , Punyawudho Baralee , Yu Ming‐Sun , Cheng Shin‐Nan , Chen Shu‐Huey , Chang Hung , Chen Chih‐Cheng , Hsiao Chih‐Cheng , Hou Jen‐Yin , Fang Yi‐Ping , Wang Hsiang‐Wei , Lin Jia‐Hong , Yu Lennex Hsueh‐Lin , Chen Yeu‐Chin 
Published: January 2022

AbstractIntroductionThe large interpatient variability in the pharmacokinetic (PK) parameters of recombinant Factor VIII (rFVIII) observed in haemophilia A hinders efficient and cost‐beneficial prophylactic regimen initiation. Identification of factors influencing the PK of rFVIII may shed more light on personalised treatment.AimThis study aimed to develop a population PK model in the Taiwanese haemophilia A and evaluate the current national health insurance (NHI) reimbursement guidelines of Taiwan for haemophilia treatment.MethodsA population PK analysis was established based on 69 Taiwanese with moderate or severe haemophilia A. A nonlinear mixed‐effects modelling (NONMEM®) was used to estimate PK parameters and their variabilities. A Monte Carlo simulation was performed to evaluate different prophylactic regimens.ResultsA two‐compartment model with first‐order elimination best described the rFVIII data. Weight‐based allometric scaling was related to clearance and central volume of distribution. Blood type and baseline von Willebrand factor (VWF) were significant covariates for clearance. For single dose simulations, a time achieving target level (> 1 IU/dL) was associated with increasing rFVIII dose and VWF level. The multiple dose simulations showed that > 96.4% of patients with high VWF level (> 200%) had predicted trough level > 1 IU/dL for all dosing regimens (15‐40 IU/kg, two to three times weekly). However, for twice weekly dosing, lower percentage (47.62‐62.20%) of patients with blood group O and low VWF level (< 50%) achieved a predicted trough level > 1 IU/dL.ConclusionThe population PK of rFVIII was successfully developed. Dose adjustment based on blood type and VWF level should be considered.
P‐Loop mutations—Negative prognosticators in tyrosine kinase inhibitors resistant chronic myeloid leukemia patients
Authors: Kaleem Bushra , Shahab Sadaf , Zaidi Uzma , Shamsi Tahir Sultan 
Published: January 2022

AbstractIntroductionP‐Loop mutations in CML patients prevent the conformational change in BCR‐ABL1 necessary for drug binding. The present study aimed to evaluate the impact of mutations in this domain on the prognosis of the disease and also to associate the baseline Sokal relative risk score with the overall survival in non‐responding CML patients.MethodsBlood samples were analyzed using ARMS‐PCR and then an association was assessed between presence/absence of mutations, hematological and molecular response, disease progression, overall survival, and Sokal score.ResultsOf the total 250 CML patients, 102 were found to be treatment‐resistant. Fifty‐three patients harbored P‐Loop mutations with G250E (12.7%) being most frequent. Complete hematological response and major molecular response were achieved by only 27.7% and 5.7 patients, respectively. Worst survival (57.1%) was observed in Y253H positive patients while according to Sokal score in high‐risk patients harboring Y253F (50%) and E255V (50%).ConclusionThe presence of P‐Loop domain mutations negatively impacted the prognosis of the disease in terms of disease advancement and overall survival. So, the timely performance of the BCR‐ABL1 mutational analysis and the modifications in the treatment plan based on the mutation identified would help in a better outcome of the disease.
The Holy Spirit and the Humanity of Christ in John Owen: A Re‐Examination
Authors: Kieser Ty 
Published: January 2022

AbstractThis article re‐examines John Owen’s construal of the Holy Spirit’s activity in the humanity of Christ. While Owen’s ‘Spirit Christology’ is both lauded as exemplary and criticized as nearly Nestorian, both positions are largely based on a shared (yet faulty) assumption regarding the key text of Owen’s ‘Spirit Christology’ (Pneumatologia 3:159–88; esp. pp. 160–1). In order to correct this assumption, this article examines the claims that Owen makes in this section of Pneumatologia within three different contexts: (1) Owen’s historical context; (2) the context of Owen’s broader corpus; and (3) the immediate context of these claims within the structure and argumentation of Pneumatologia as a whole. I suggest that this rereading of Owen’s Spirit Christology is able to retain many of the desirable theological implications of the original interpretation without the same theological difficulties.
The contribution of intraspecific trait variation to changes in functional community structure along a stress gradient
Authors: Kitagawa Ryo , Masumoto Shota , Kaneko Ryo , Uchida Masaki , Mori Akira S. 
Published: January 2022

AbstractQuestionWe considered two possibilities related to the contribution of intraspecific trait variation (ITV) to changes in functional community structure along a stress gradient in tundra vegetation. First, ITV could contribute to the success of plant species across the stress gradient by promoting optimal trait values for each condition along the gradient; thus, ITV enhances convergence toward optimal traits. Second, ITV of only a few dominant species aligns with the optimal trait, and ITV of other species promotes trait diversification within communities.LocationSalluit, Québec, Canada (62°12′N, 75°39′W).MethodsVegetation was surveyed under three different conditions (harsh, intermediate, and competitive) representing an environmental stress gradient. We assessed ITV across the gradient for four plant functional traits: leaf carbon (C) and nitrogen (N) contents, specific leaf area (SLA), and plant height. We assessed community‐weighted means (CWMs) and functional dispersion (FDis) for each of the four traits. These indices were calculated from mean trait values from all individuals across all habitats (mean‐CWM and mean‐FDis), and from each habitat (ITV‐CWM and ITV‐FDis).ResultsFor the four traits, increasing trends (leaf N content, SLA, and plant height) and decreasing trends (leaf C content) in mean‐CWM along the stress gradient were maintained and pronounced for ITV‐CWM. Comparisons between ITV‐FDis and mean‐FDis suggested that, except for leaf C content, ITV tends to reduce and increase FDis values at the abiotically stressful and competitive ends of the environmental stress gradient, respectively.ConclusionsITV along the abiotic stress–competition gradient appears to promote community‐level changes towards optimal traits. In particular, ITV in three traits (with the exception of leaf C content) may contribute to equalization of optimal trait values, and to “passage through environmental filtering” in harsh habitats. However, when species deal with competition for richer resources, only some dominant species may show optimal trait values. Therefore, ITV may allow for trait diversification within communities under competitive rather than harsh abiotic conditions.