bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERIOD – PERASPERA In-Orbit Demonstration toward the transition into the in-space services, assembly and manufacturing paradigm
Authors: Estable Stéphane , Ampe Annelies , Chamos Apostolos , Aridon Gwenaelle , Silveira Daniel , Lechuga Francisco Javier Colmenero , Soto Isabel , Gancet Jeremi , Shilton Mark , Jankovic Marko , Vogel Torsten 
Published: February 2022

Abstract
Space robotics technologies are maturing, bringing new capabilities for In-orbit Services, Manufacturing and Assembly (ISMA). These capabilities will generate on-orbit services improving the orbital infrastructure, creating in turn a very promising business opportunity in terms of market volume. The establishment of a European capacity is necessary for building this new space infrastructure and to capture a fair part of this market. The concrete objectives of the PERIOD project are focusing on the main levers to generate the capabilities, which are the further maturation of the space robotics technologies and the definition of an in-orbit demonstration to be implemented as early as 2026. In the frame of the PERASPERA Strategic Research Cluster (SRC), key enabling products have been selected for technology maturation aiming at an increased technology readiness level (TRL). In support of the PERIOD activities, ESROCOS, ERGO and InFuse will be developed to TRL5 after an alignment of their perimeter to the demonstration objectives. The Standard Interconnects (SI), already at TRL5 at project start, will be tested in a benchmark for evaluating their performance. These SRC building blocks will be integrated in a breadboard at Airbus for supporting the system definition work. The PERIOD Consortium bringing together the competencies of Airbus Defence and Space, DFKI, EASN-TIS, GMV, ISISPACE, SENER Aerospacial and Space Application Services is proposing a very ambitious demonstration scenario and Factory concept. A satellite will be manufactured in an Orbital Factory to be designed in the study at SRR level and injected in LEO for operations. The manufacturing includes the fabrication of an antenna, the assembly of the satellite components and its reconfiguration and inspection in the Factory. Throughout the demonstration mission, the PERIOD facility will be upgraded to extend the level of capability validation from assembly and manufacturing of structures to attachment and refuelling experiments. Dissemination activities will maximize the impact of the project toward the Space Community. This demonstration covers the short and mid-to-long term ISMA business cases and will support the transition into the in-space services, assembly and manufacturing paradigm.
The TecALSens project: new solutions for load sensors in aeronautics
Authors: Carli Valerio 
Published: February 2022

Abstract
In this paper the TecALSens project, developed within the Systems ITD of the Clean Sky 2 programme, is presented. The objective of the project is to design and validate a novel load sensor for aeronautic application based on thin-film sensing technology. So far, thin-film as sensing element has not been used in commercial aeronautic products: The outcome of this project tries to close this gap by providing a new class of load sensors complying with demanding aeronautic requirements. More and all electric aircraft configuration can benefit from the implementation of force measurement. This is an example of revolutionary approach to A/C design and a key enabler for achieving the environmental goals set by the European agenda up to 2050. Current project activities show very promising results: TecALSens provides a new approach to the design and manufacturing of load sensors for aeronautic applications. Especially, this new class of load sensors overcomes some of the drawbacks of strain gauge-based solutions. The final outcome of the project complies with the expected technology readiness level (TRL) 5. TecALSens outcome widens the possibilities offered by force sensing in aeronautics and strongly supports the evolution of aircraft design toward a more environmental friendly approach.
Fault-tolerant control via four-leg inverter of a full-electric propulsion system for lightweight fixed-wing UAVs
Authors: Rito Gianpietro Di , Suti Aleksander , Galatolo Roberto 
Published: February 2022

Abstract
The work deals with the development and the performance characterization of a novel control strategy for the detection, isolation and accommodation of coil faults in a three-phase Permanent Magnet Synchronous Motor (PMSM), used to drive the propeller of a modern lightweight fixed-wing UAV. The health-monitoring algorithms on motor currents (used to detect the open-circuit fault and to activate the control reconfiguration) are based on a slope method, associated to the evaluation of the current phasor trajectory in the Clarke plane. Actually, when an open-circuit fault occurs in PMSM driven by a standard three-leg converter, the typical circular trajectory of the current phasor in the Clarke plane collapses into a linear track and relevant torque ripples are generated. On the other hand, if the PMSM is driven by a four-leg converter, a control reconfiguration can be applied: the fourth leg of the power bridge is in stand-by when the system operates without faults, but it is enabled to regulate the current flowing at the central point of the Y connection of the 3-phase PMSM. The performances of the fault-tolerant algorithms are assessed via detailed nonlinear simulation of the propulsion system (including propeller loads, electrical faults, mechanical transmission compliance, digital signal processing and sensors errors). The results demonstrate that the health-monitoring algorithms and the fault-tolerant control strategies permit to obtain extremely small detection and isolation latencies, and negligible performance degradation in terms PMSM torque.
Enabling In-Flight Connectivity with the new Generation of Electronically Steered Antennas
Authors: Gonzalez Manuel J , Ruiz Ana , Pellon Alberto , Flores Jose Luis , Garcia Palma , Howland Keith , Silverthorn Nigel , Perez-de-Diego Jaime 
Published: February 2022

Abstract
In-flight communication (IFC) services offered to passengers and crew are of great importance to the air transport sector. The improvement of the satellite capacity with High Throughput Satellites (HTS) in GEO and the advent of MEO and LEO constellations will support the forecast growth of the IFC market. Antenna equipment for satellite communications will need to address multiple scenarios from G2G (Gate-to-Gate) to multi-operation under GEO-MEO-LEO systems. Under these conditions, antennas with the ability to track multiple satellites and having superior performance and reliability will play a key role. Electronically steered antennas (ESA) have emerged as a viable solution in response to these demands. The EU-funded LESAF project proposes an ESA solution of reduced size and greater efficiency for the next generation of in-flight connectivity services. This will be managed through the requirements definition, system analysis, technology assessment, prototyping and validation of ESAs. The project has successfully passed the first milestone corresponding to requirements consolidation, baseline architecture definition and candidate technology trade-offs. Multi-beam Electronically Steered Antennas, separated apertures for both transmission and reception, a flexible modular approach coupled with planar multilayer integration and an advanced beamformer design are the basis for the proposed concept. The following project phase will be focused on the design and validation of an antenna demonstrator aimed at proving the superior added value of ESAs technological solution for the aviation industry needs.
Quantum capacitive coupling between large-angle twisted graphene layers
Authors: Mreńca-Kolasińska Alina , Rickhaus Peter , Zheng Giulia , Richter Klaus , Ihn Thomas , Ensslin Klaus , Liu Ming-Hao 
Published: February 2022

Abstract
Large-angle twisted bilayer graphene (tBLG) is known to be electronically decoupled due to the spatial separation of the Dirac cones corresponding to individual graphene layers in the reciprocal space. The close spacing between the layers causes strong capacitive coupling, opening possibilities for applications in atomically thin devices. Here, we present a self-consistent quantum capacitance model for the electrostatics of decoupled graphene layers, and further generalize it to deal with decoupled tBLG at finite magnetic field and large-angle twisted double bilayer graphene at zero magnetic field. We probe the capacitive coupling through the conductance, showing good agreement between simulations and experiments for all the systems considered. We also propose a new experiment utilizing the decoupling effect to induce a huge and tunable bandgap in bilayer graphene by applying a moderately low bias. Our model can be extended to systems composed of decoupled graphene multilayers as well as non-graphene systems, opening a new realm of quantum-capacitively coupled materials.
Embodied Prosodic Training Helps Improve Accentedness and Suprasegmental Accuracy
Authors: Baills Florence , Alazard-Guiu Charlotte , Prieto Pilar 
Published: February 2022

Abstract
With increasing evidence in favour of embodied learning techniques, more research is needed to explore eventual applications in the field of second language acquisition, for example, the effect of embodied training on phonological learning. This study investigated how pronunciation was affected by visuospatial hand gestures depicting speech rhythm and intonation during the oral repetition of logatomes (i.e. a series of identical nonsense CV syllables that maintain prosodic structure intact). Seventy-five Catalan learners of French participated in three training sessions with short dialogues, in one of three conditions: speech-only, non-embodied logatome, and embodied logatome. Before and after the training period, participants carried out an identical pre- and posttest which consisted of reading four dialogues aloud. Their oral output was evaluated in terms of fluency, comprehensibility, accentedness, and suprasegmental and segmental features by three native French speakers. While all three groups significantly improved in all measures after training, the embodied logatome group improved significantly more in terms of accentedness and suprasegmental features compared with the speech-only group, while the non-embodied logatome group did not.
Librator: a platform for the optimized analysis, design, and expression of mutable influenza viral antigens
Authors: Li Lei , Changrob Siriruk , Fu Yanbin , Stovicek Olivia , Guthmiller Jenna J , McGrath Joshua J C , Dugan Haley L , Stamper Christopher T , Zheng Nai-Ying , Huang Min , Wilson Patrick C 
Published: February 2022

Abstract
Artificial mutagenesis and protein engineering have laid the foundation for antigenic characterization and universal vaccine design for influenza viruses. However, many methods used in this process require manual sequence editing and protein expression, limiting their efficiency and utility in high-throughput applications. More streamlined in silico tools allowing researchers to properly analyze and visualize influenza viral protein sequences with accurate nomenclature are necessary to improve antigen design and productivity. To address this need, we developed Librator, a system for analyzing and designing custom protein sequences of influenza virus hemagglutinin (HA) and neuraminidase (NA) glycoproteins. Within Librator’s graphical interface, users can easily interrogate viral sequences and phylogenies, visualize antigen structures and conservation, mutate target residues and design custom antigens. Librator also provides optimized fragment design for Gibson Assembly of HA and NA expression constructs based on peptide conservation of all historical HA and NA sequences, ensuring fragments are reusable and compatible across related subtypes, thereby promoting reagent savings. Finally, the program facilitates single-cell immune profiling, epitope mapping of monoclonal antibodies and mosaic protein design. Using Librator-based antigen construction, we demonstrate that antigenicity can be readily transferred between HA molecules of H3, but not H1, lineage viruses. Altogether, Librator is a valuable tool for analyzing influenza virus HA and NA proteins and provides an efficient resource for optimizing recombinant influenza antigen synthesis.
Fréchet sufficient dimension reduction for random objects
Authors: Ying Chao , Yu Zhou 
Published: February 2022

Summary
We consider Fréchet sufficient dimension reduction with responses being complex random objects in a metric space and high-dimensional Euclidean predictors. We propose a novel approach, called the weighted inverse regression ensemble method, for linear Fréchet sufficient dimension reduction. The method is further generalized as a new operator defined on reproducing kernel Hilbert spaces for nonlinear Fréchet sufficient dimension reduction. We provide theoretical guarantees for the new method via asymptotic analysis. Intensive simulation studies verify the performance of our proposals, and we apply our methods to analyse handwritten digit data and real-world affective face data to demonstrate its use in real applications.
Perspectives on Coping with Post-traumatic Stress and Substance Use Disorders: A Photovoice Study
Authors: Dell Nathaniel A , Brandt-Lubart Kyle , Maynard Brandy R 
Published: February 2022

Abstract
This photovoice study explores the experiences of adaptive coping and safety amongst adults with co-occurring post-traumatic stress disorder (PTSD) and substance use disorder (SUD). Participants (n = 6) were purposively sampled from Seeking Safety groups at a community mental health centre in the United States of America. Participants identified primarily as women (83 per cent), white (50 per cent) and had a mean age of 42 years (standard deviation = 11). Data were gathered through individual photo-elicitation interviews. Through reflexive thematic analysis, the authors generated five themes related to coping safely with distress: (1) similar to other views on mental health recovery, the process of learning to cope with distress was framed as a journey; (2) participants cited several behavioural and meaning-making strategies for coping with distress; (3) feelings of agency were promoted through mastery of wellness skills; (4) healthy personal and professional relationships contributed to positive growth and use of adaptive coping strategies; and (5) participants’ social and physical environments greatly impacted perceptions of safety. Findings provide new evidence on the range of adaptive coping strategies persons with SUD and PTSD employ to realise feelings of safety and the assets relationships and communities can provide to support post-traumatic growth and recovery.
The effect of external stimulation on functional networks in the aging healthy human brain
Authors: Escrichs Anira , Sanz Perl Yonatan , Martínez-Molina Noelia , Biarnes Carles , Garre-Olmo Josep , Fernández-Real José Manuel , Ramos Rafel , Martí Ruth , Pamplona Reinald , Brugada Ramon , Serena Joaquin , Ramió-Torrentà Lluís , Coll-De-Tuero Gabriel , Gallart Luís , Barretina Jordi , Vilanova Joan C , Mayneris-Perxachs Jordi , Saba Luca , Pedraza Salvador , Kringelbach Morten L , Puig Josep , Deco Gustavo 
Published: February 2022

Abstract
Understanding the brain changes occurring during aging can provide new insights for developing treatments that alleviate or reverse cognitive decline. Neurostimulation techniques have emerged as potential treatments for brain disorders and to improve cognitive functions. Nevertheless, given the ethical restrictions of neurostimulation approaches, in silico perturbation protocols based on causal whole-brain models are fundamental to gaining a mechanistic understanding of brain dynamics. Furthermore, this strategy could serve to identify neurophysiological biomarkers differentiating between age groups through an exhaustive exploration of the global effect of all possible local perturbations. Here, we used a resting-state fMRI dataset divided into middle-aged (N =310, &lt;65 years) and older adults (N =310, $\geq $65) to characterize brain states in each group as a probabilistic metastable substate (PMS) space. We showed that the older group exhibited a reduced capability to access a metastable substate that overlaps with the rich club. Then, we fitted the PMS to a whole-brain model and applied in silico stimulations in each node to force transitions from the brain states of the older- to the middle-aged group. We found that the precuneus was the best stimulation target. Overall, these findings could have important implications for designing neurostimulation interventions for reversing the effects of aging on whole-brain dynamics.
Environmental enrichment recruits activin A to recalibrate neural activity in mouse hippocampus
Authors: Dahlmanns Marc , Dahlmanns Jana Katharina , Schmidt Carla C , Valero-Aracama Maria Jesus , Zheng Fang , Alzheimer Christian 
Published: February 2022

Abstract
The TGF-β family member activin A modulates neural underpinnings of cognitive and affective functions in an activity-dependent fashion. We have previously shown that exploration of a novel and enriched environment (EE) strongly enhanced activin signaling. Whereas the many beneficial effects of EE are amply documented, the underlying mechanisms remain largely elusive. Here, we examined the hypothesis that EE recruits activin to regulate synaptic plasticity in a coordinated, cognition-promoting manner. Elevated activin levels after EE enhanced CA1 pyramidal cell excitability, facilitated synaptic transmission, and promoted long-term potentiation. These EE-induced changes were largely absent in mice expressing a dominant-negative mutant of activin receptor IB. We then interrogated the impact of activin on network oscillations and functional connectivity, using high-speed Ca 2+ imaging to study spike routing within networks formed by dissociated primary hippocampal cultures. Activin facilitated Ca2+ signaling, enhanced the network strength, and shortened the weighted characteristic path length. In the slice preparation, activin promoted theta oscillations during cholinergic stimulation. Thus, we advance activin as an activity-dependent and very early molecular effector that translates behavioral stimuli experienced during EE exposure into a set of synchronized changes in neuronal excitability, synaptic plasticity, and network activity that are all tuned to improve cognitive functions.
Management of Neisseria gonorrhoeae in the United States: Summary of Evidence From the Development of the 2020 Gonorrhea Treatment Recommendations and the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infection Treatment Guidelines
Authors: Barbee Lindley A , St. Cyr Sancta B 
Published: February 2022

Abstract

Introduction
Neisseria gonorrhoeae has developed resistance to all first-line recommended therapies, making gonococcal antimicrobial resistance a major public health concern given limited antibiotic options currently and an even smaller antimicrobial development pipeline. Since the release of the Centers for Disease Control and Prevention (CDC) 2015 STD Treatment Guidelines, azithromycin, part of the 2015 dual-drug treatment regimen, has had a rapid rise in resistance. The 2020 CDC Gonorrhea Treatment Recommendations and the 2021 Sexually Transmitted Infections (STI) Treatment Guidelines were developed weighing the priorities of treating the individual, protecting the population, and preventing antimicrobial resistance.

Methods
Gonorrhea subject matter experts (SME) generated 8 key questions and conducted a literature review of updated data from 2013 to 2019 on gonorrhea antimicrobial resistance, treatment failures, clinical trials, and other key topics. More than 2200 abstracts were assessed, and 248 clinically relevant articles were thoroughly reviewed. SMEs also evaluated N gonorrhoeae antimicrobial resistance data from the Gonococcal Isolate Surveillance Project (GISP).

Evidence
Although there have been reports of ceftriaxone treatment failures internationally, GISP data suggest that ceftriaxone minimal inhibitory concentrations (MICs) have remained stable in the United States, with &lt; 0.1% exhibiting an “alert value” MIC (&gt; 0.25 mcg/mL). However, GISP documented a rapid rise in the proportion of isolates with an elevated MIC (≥ 2.0 mcg/mL) to azithromycin—nearly 5% in 2018. At the same time, new pharmacokinetic/pharmacodynamic data are available, and there is greater recognition of the need for antimicrobial stewardship.

Summary
The 2021 CDC STI Treatment Guidelines now recommend 500mg ceftriaxone intramuscularly once for the treatment of uncomplicated gonorrhea at all anatomic sites. If coinfection with chlamydia has not been excluded, cotreatment with doxycycline 100mg twice daily for 7 days should be added. Few alternative therapies exist for persons with cephalosporin allergies; there are no recommended alternative therapies for N gonorrhoeae infection of the throat.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection by Intranasal or Intratesticular Route Induces Testicular Damage
Authors: Li Can , Ye Zhanhong , Zhang Anna Jin Xia , Chan Jasper Fuk Woo , Song Wenchen , Liu Feifei , Chen Yanxia , Kwan Mike Yat Wah , Lee Andrew Chak Yiu , Zhao Yan , Wong Bosco Ho Yin , Yip Cyril Chik Yan , Cai Jian Piao , Lung David Christopher , Sridhar Siddharth , Jin Dongyan , Chu Hin , To Kelvin Kai Wang , Yuen Kwok Yung 
Published: February 2022

Abstract

Background
The role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the pathogenesis of testicular damage is uncertain.

Methods
We investigated the virological, pathological, and immunological changes in testes of hamsters challenged by wild-type SARS-CoV-2 and its variants with intranasal or direct testicular inoculation using influenza virus A(H1N1)pdm09 as control.

Results
Besides self-limiting respiratory tract infection, intranasal SARS-CoV-2 challenge caused acute decrease in sperm count, serum testosterone and inhibin B at 4–7 days after infection; and chronic reduction in testicular size and weight, and serum sex hormone at 42–120 days after infection. Acute histopathological damage with worsening degree of testicular inflammation, hemorrhage, necrosis, degeneration of seminiferous tubules, and disruption of orderly spermatogenesis were seen with increasing virus inoculum. Degeneration and death of Sertoli and Leydig cells were found. Although viral loads and SARS-CoV-2 nucleocapsid protein expression were markedly lower in testicular than in lung tissues, direct intratesticular injection of SARS-CoV-2 demonstrated nucleocapsid expressing interstitial cells and epididymal epithelial cells, While intranasal or intratesticular challenge by A(H1N1)pdm09 control showed no testicular infection or damage. From 7 to 120 days after infection, degeneration and apoptosis of seminiferous tubules, immune complex deposition, and depletion of spermatogenic cell and spermatozoa persisted. Intranasal challenge with Omicron and Delta variants could also induce similar testicular changes. This testicular damage can be prevented by vaccination.

Conclusions
SARS-CoV-2 can cause acute testicular damage with subsequent chronic asymmetric testicular atrophy and associated hormonal changes despite a self-limiting pneumonia in hamsters. Awareness of possible hypogonadism and subfertility is important in managing convalescent coronavirus disease 2019 in men.