bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of local intraoperative epidural use of triamcinolone acetonide–soaked Gelfoam on postoperative outcomes in patients undergoing posterolateral lumbar spinal fusion surgery: a randomized, placebo-controlled, double-blind trial
Authors: Tavanaei Roozbeh , Ahmadi Pooria , Malekipour Bahador , Herfedoust Biazar Bijan , Keikhaee Mohsen , Oraii Yazdani Kaveh , Zali Alireza , Oraee-Yazdani Saeed 
Published: April 2022

OBJECTIVE
Prior evidence has supported the use of local intraoperative epidural steroids in lumbar discectomy for improvements in postoperative pain and outcomes. However, currently there is a paucity of data regarding the efficacy of local epidural steroids in spinal fusion procedures. The present investigation aimed to evaluate the impact of local epidural administration of triamcinolone acetonide–soaked Gelfoam on postoperative pain and patient-reported outcomes in patients undergoing instrumented posterolateral lumbar spinal fusion.

METHODS
In this randomized, double-blind, placebo-controlled trial, patients were randomly divided into two groups (treatment and control). Patients in the treatment group received a Gelfoam carrier soaked in 1 ml of triamcinolone acetonide (40 mg), which was placed over the nerve roots in the epidural space before the closure. Patients in the control group received a Gelfoam carrier soaked in normal saline in a similar fashion to the treatment group. Patients were followed up during their hospital stay and at 4 and 12 weeks postoperatively. The primary outcome measure was early postoperative visual analog scale (VAS) scores for pain both at rest and with movement.

RESULTS
A total of 100 patients were recruited in this study and were randomly allocated to the treatment or control group. No significant difference was found in baseline demographic, clinical, and surgical characteristics between the two groups. Postoperative VAS scores for pain both at rest and with movement were comparable between the treatment and control groups. Cumulative morphine consumption, length of hospital stay, and incidence of postoperative complications such as surgical site infection were also similar between the two groups. There was no significant difference in patient-reported outcomes including VAS scores for back and leg pain as well as the Oswestry Disability Index at 4 and 12 weeks postoperatively. The proportion of patients who achieved a minimum clinically important difference for patient-reported outcomes were also similar between the two groups.

CONCLUSIONS
In contrast to the existing literature on the beneficial use of local intraoperative epidural steroids in conventional lumbar discectomy, the present study did not demonstrate such significant efficacy for the use of local epidural steroids in instrumented posterolateral lumbar spinal fusion. However, there is still a lack of evidence in this regard and further high-quality clinical trials are required to evaluate the efficacy of local epidural steroids in this group of patients.
Optimal targeting of the anterior nucleus of the thalamus for epilepsy: a meta-analysis
Authors: Ilyas Adeel , Snyder Kathryn M. , Thomas Tessy M. , Tandon Nitin 
Published: April 2022

OBJECTIVE
Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) has been shown to be an effective therapeutic option for select patients with limbic epilepsy. However, the optimal target and electrode position for this indication remains undefined. Therefore, the objective of this systematic review and meta-analysis is to quantify the association between active contact location and outcomes across all published series of ANT DBS.

METHODS
A literature search using PRISMA criteria was performed to identify all studies that reported both active contact locations and outcomes of DBS in the ANT for epilepsy. Patient, disease, treatment, and outcome data were extracted for statistical analysis. Contact locations of responders (defined as ≥ 50% seizure reduction at last follow-up) versus nonresponders to DBS were analyzed on a common reference frame. Centers of mass, weighted by clinical response, were computed for the contacts in each cohort.

RESULTS
From 555 studies that were screened for review, a total of 7 studies comprising 162 patients met criteria for inclusion and were analyzed. Across the cohort, the mean duration of epilepsy was 23 years and the mean pre-DBS seizure frequency was 56 seizures per month. DBS electrodes were implanted using direct targeting in 5 studies (n = 62, 38% of patient cohort) via a transventricular electrode trajectory in 4 studies (n = 123, 76%). At the mean follow-up duration of 2.3 years, 56% of patients were considered responders. Active contacts of responders were 1.6 mm anterior (95% CI 1.5–1.6 mm, p < 0.001) compared to those of nonresponders and were adjacent to the mammillothalamic tract (MTT).

CONCLUSIONS
Accurate targeting of the ANT is crucial to successful DBS outcomes in epilepsy. These findings suggest that stimulation within the ANT subregions adjacent to the MTT improves outcomes.
Surgical outcomes of patients who fail to reach minimal clinically important differences: comparison of minimally invasive versus open transforaminal lumbar interbody fusion
Authors: Ayling Oliver G. S. , Rampersaud Y. Raja , Dandurand Charlotte , Yuan Po Hsiang (Shawn) , Ailon Tamir , Dea Nicolas , McIntosh Greg , Christie Sean D. , Abraham Edward , Bailey Christopher S. , Johnson Michael G. , Bouchard Jacques , Weber Michael H. , Paquet Jerome , Finkelstein Joel , Stratton Alexandra , Hall Hamilton , Manson Neil , Thomas Kenneth , Fisher Charles G. 
Published: April 2022

OBJECTIVE
Treatment of degenerative lumbar diseases has been shown to be clinically effective with open transforaminal lumbar interbody fusion (O-TLIF) or minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF). Despite this, a substantial proportion of patients do not meet minimal clinically important differences (MCIDs) in patient-reported outcomes (PROs). The objectives of this study were to compare the proportions of patients who did not meet MCIDs after O-TLIF and MIS-TLIF and to determine potential clinical factors associated with failure to achieve MCID.

METHODS
The authors performed a retrospective analysis of consecutive patients who underwent O-TLIF or MIS-TLIF for lumbar degenerative disorders and had been prospectively enrolled in the Canadian Spine Outcomes and Research Network. The authors analyzed the Oswestry Disability Index (ODI) scores, physical and mental component summary scores of SF-12, numeric rating scale (NRS) scores for leg and back pain, and EQ-5D scores of the patients in each group who did not meet the MCID of ODI at 2 years postoperatively.

RESULTS
In this study, 38.8% (137 of 353) of patients in the O-TLIF cohort and 41.8% (51 of 122) of patients in the MIS-TLIF cohort did not meet the MCID of ODI at 2 years postoperatively (p = 0.59). Demographic variables and baseline PROs were similar between groups. There were improvements across the PROs of both groups through 2 years, and there were no differences in any PROs between the O-TLIF and MIS-TLIF cohorts. Multivariable logistic regression analysis demonstrated that higher baseline leg pain score (p = 0.017) and a diagnosis of spondylolisthesis (p = 0.0053) or degenerative disc disease (p = 0.022) were associated with achieving the MCID at 2 years after O-TLIF, whereas higher baseline leg pain score was associated with reaching the MCID after MIS-TLIF (p = 0.038).

CONCLUSIONS
Similar proportions of patients failed to reach the MCID of ODI at 2 years after O-TLIF or MIS-TLIF. Higher baseline leg pain score was predictive of achieving the MCID in both cohorts, whereas a diagnosis of spondylolisthesis or degenerative disc disease was predictive of reaching the MCID after O-TLIF. These data provide novel insights for patient counseling and suggest that either MIS-TLIF or O-TLIF does not overcome specific patient factors to mitigate clinical success or failure in terms of the intermediate-term PROs associated with 1- to 2-level lumbar fusion surgical procedures for degenerative pathologies.
Faktor-Faktor Mempengaruhi Terjadinya Perilaku Perundungan(Bullying) pada Siswa SMPN Se-Kecamatan Kediri Lombok Barat
Authors: Haslan Muhammad Mabrur , Sawaludin Sawaludin , Fauzan Ahmad 
Published: April 2022

Penelitian ini bertujuan mengidentifikasi faktor-faktor yang mempengaruhi perilaku perundungan (bullying) bagi siswa SMP Negeri Se-Kecamatan Kediri Lombok Barat. Hasil Penelitian sebagai berikut: faktor-faktor yang mempengaruhi perilaku perundungan (bullying) bagi siswa SMP Negeri Se-Kecamatan Kediri Lombok Barat yaitu: faktor keluarga (perceraian orang tua, orang tua yang bekerja di luar negeri), faktor , faktor ekonomi, dan faktor lingkungan sosialThis study aims: to identify factors influence behavior bullying for yunior high school Kediri Disrtrict West Lombok (3) to identify impact behavior bullying for yunior high school Kediri District West Lombok.The Results of research etc: to identify factors influence behavior bullying for yunior high school Kediri Disrtrict West Lombok, such as: family problem factor (divorce, labor), economic factor, and social invironment
National innovation systems and technology transfer of SCO countries
Authors: Solovieva Yuliana 
Published: April 2022

The article considers the forms and conditions of interaction between the participants in the innovation process, the specialties of creating and developing the organizational system of technology transfer in the member countries of the Shanghai Cooperation Organization (SCO). Based on the analysis of transfer systems operating in various countries (China, Kazakhstan, Kyrgyzstan, Russia, Tajikistan, Uzbekistan), the authors highlight key and most promising areas for the development of integration of the scientific, educational, industrial spheres and the state in order to form special mechanisms for organizing innovative processes that ensure effective interaction between all its participants. The purpose of the article is to analyze the national innovation systems of SCO member countries, since each of these countries has gone its own way of innovative development, justified by regional characteristics (climatic, cultural, socio-economic, etc.). As basic research methods we used system approach, comparative and statistical analysis of indicative values of innovation and technological development of the SCO member countries.The authors conclude that it is necessary to create an organizational system based on the integration of state institutions, science, business and education in the Shanghai Cooperation Organization member countries in order to form competitive high-tech products, improve the export structure by increasing the share of innovative products in it and reducing the raw materials orientation, and increase the status of countries in the world technology market.
Desain Prototipe Handwell Universal Tool Grinding Machine Menggunakan Konsep Manufaktur Teknologi 3D Printer
Authors: Ratlalan Roberth Marshall 
Published: April 2022

Abstract : The presence of the manufacturing world has brought a huge impact on the progress of science and technology in the industry which is currently growing rapidly, especially in the field of industrial automation. Additive Manufacturing known as 3D printing Technology in its philosophy of helping humans in completing every task by playing a very important role in product development, prototyping, and manufacturing process.The results of the manufacturing process using a 3D printer are very good, where the design results can be translated to a 3D Printer and produce objects that match the design results from the software inventor. Success in this manufacturing process is obtained from the results of setting the 3D printer parameters during the proper slicing process, such as setting material temperature, support, printer speed, fan speed, layer thickness (quality), wall thickness (Shell), Infill (filler). and others.Â Keywords: Prototype Design, 3D Printer, Manufacturing Process
Use of Diperoxocholric Acid in Infected Diabetic Foot Ulcers Leading to Osteomyelitis: Case Reports
Authors: K V N N Santosh Murthy  , Katke Vaishali , Kiran Mayuresh 
Published: April 2022

This article describes three patients who had an episode of infected diabetic foot ulcer with osteomyelitis, and subsequently treated with a Diperoxochloric acid topical solution. Diperoxochloric acid is a new chemical entity approved in the treatment of diabetic foot ulcer. It has properties to heal the wound and kill the microbes in wound, which is the need of hour. As most of the products that are available in market have either antimicrobial activity or wound growth factors, which have no action on microbes makes Diperoxochloric acid mechanism unique. All three ulcers showed positive wound contraction and reduction in size throughout the follow-up period ranging from 3 to 10 weeks. All the three patients showed positive signs of wound healing. One of the patients in whom amputation of great toe was advised also healed completely without any need of amputation.
Keywords: Diabetic foot ulcer, Diperoxochloric acid
Pengujian Validitas dan Reliabilitas System Usability Scale (SUS) Untuk Perangkat Smartphone
Authors: Usman Muhammad Lulu Latif , Gustalika Muhamad Azrino 
Published: April 2022

Untuk mengukur suatu perangkat lunak lebih spesifik berbasis telepon seluler smartphone dapat diterima oleh pengguna maka dilakukan pengujian Usability. Untuk membuat quisioner yang dapat digunakan untuk melakukan pengujian System Usability Scale (SUS) yang dinyatakan valid dan reliabel. Quisioner diuji menggunakan Expert Review dan Product-Moment Coefficient untuk uji validitas, serta Cronbach Alfa untuk uji reliabilitas. Berdasarkan hasil uji yang dilakukan didapatkan 10 butir quisioner untuk uji SUS dengan seluruh butir dinyatakan valid secara Expert Review dan Product-Moment Coefficient, serta reliabel dengan skor Cronbach Alfa 0,778086452. Terdapat beberapa penelitian terkait pembuatan quisioner untuk uji SUS dimana bahasa yang digunakan bahasa indonesia dan bahasa inggris dengan jumlah pertanyaan sebanyak 10 butir. Penelitian ini sendiri memberikan opsi lain quisioner dengan mengadopsi penelitian yang sudah dilakukan dengan melakukan pengujian validitas dan realibilitas untuk menguji suatu perangkat lunak menggunakan uji SUS.
ANALISIS SGOT DAN SGPT PADA TIKUS JANTAN YANG DI INDUKSI PARASETAMOL UNTUK MENETAPKAN AKTIVITAS EKSTRAK BUAH DELIMA (Punica granatum L.) SEBAGAI HEPATOPROTEKTIF
Authors: Nofita Nofita , Ulfa Ade Maria , Muslim Davit Muhamad 
Published: April 2022

Enzim SGOT dan SGPT berhubungan dengan sel parenkim hati yang dikeluarkan akibat kerusakan sel hati. Pengaruh Punica granatum pada enzim hati dapat dirujuk ke pada efektivitas antioksidan yang kuat dari senyawa aktifnya yang dapat berinteraksi dengan radikal bebas. Penelitian ini bertujuan untuk menyelidiki kemungkinan aktivitas hepatoprotektif ekstrak buah delima terhadap hepatotoksisitas yang diinduksi parasetamol. Hepatotoksisitas diinduksi pada tikus jantan Sprague Dawley dengan pemberian oral parasetamol dosis 2000 mg/kg berat badan pada hari ke 9, 2 jam setelah pemberian ekstrak buah delima dan silymarin. Ekstrak dari buah delima diberikan secara oral dengan dosis 200 mg/kg dan 400 mg/kg BB dan silymarin diberikan secara oral dengan dosis 100 mg/kg setiap hari selama 9 hari. Beberapa penanda seperti SGOT dan SGPT diukur untuk menilai efek ekstrak pada kerusakan hati yang disebabkan oleh parasetamol. Sampel darah dari tikus yang diberi ekstrak buah delima 200 mg / kg BB dan 400 mg / kg BB memberikan kadar SGOT dan SGPT yang lebih rendah di bandingkan kontrol negatif (paracetamol) menunjukkan efek ekstrak dalam mencegah kerusakan akibat hepatoksin, akan tetapi efek yang diberikan belum mampu menyamai kontro positif pada kadar SGOT. Silymarin digunakan sebagai obat kontrol positif. Sehingga perlu adanya penambahan waktu pemberian dan dosis dari ekstrak buah delima sehingga efek yang dihasilkan lebih baik. Kata Kunci : Buah Delima, Hepatoprotektif, SGOT, SGPT, Parasetamol
UJI EFEKTIFITAS EKSTRAK DAUN KOPI ROBUSTA (Coffea Robusta) SEDIAAN GEL TERHADAP BAKTERI Propionibacterium acnes
Authors: Marcellia Selvi , Tutik Tutik , Romadhon Sukma 
Published: April 2022

Jerawat merupakan masalah kulit yang sering dialami oleh masyarakat terutama usia remaja. Jerawat disebabkan oleh bakteri Propionibacterium acnes. Daun kopi robusta memiliki khasiat sebagai anti jerawat. Zat aktif pada daun kopi robusta dapat diperoleh dengan ekstraksi menggunakan metode perkolasi dengan pelarut etanol 96%. Metode perkolasi leih efektif dibandingkan dengan metode maserasi karena menghasilkan rendemen yang lebih sempurna. Pada uji fitokimia menunjukan bahwa didalam ekstrak daun kopi robusta positif mengandung alkaloid, tanin, flavonoid dan saponin. Ekstrak daun kopi robusta yang diperoleh dibuat dalam sediaan gel dengan konsentrasi 0,1%, 0,5% 1% dan 2%. Evaluasi gel meliputi uji aya sebar, uji daya lekat, uji homogenitas, uji pH dan uji organoleptis. Uji daya hambat gel ektrak daun kopi robusta menggunakan metode difusi sumuran. Efektifitas zona hambat tertinggi yang terbentuk pada konsentrasi 2% sebesar 28.38%. Hasil uji antibakteri dianilisis menggunakan ANOVA. Hasil analisis statistik menunjukan ada perbedaan zona hambat yang signifikan yaitu nilai p=<0,005 antara seluruh konsentrasi gel ekstrak daun kopi robusta. Semakin tinggi konsentrasi gel ekstrak daun kopi robusta maka semakin luas diameter zona hambat. Gel ekstrak daun kopi robusta efektif dalam menghambat bakteri Propionibacterium acnes. Kata kunci : Propionibacterium acnes, Jerawat, Gel ekstrak daun kopi robusta.
FORMULASI SEDIAAN GEL EKSTRAK KULIT BAWANG MERAH (Allium cepa L.) SEBAGAI ANTIJERAWAT TERHADAP BAKTERI Propionibacterium acnes
Authors: Tutik Tutik , Feladita Niken , Evaliana Kadek 
Published: April 2022

Bakteri Propionibacterium acnes merupakan bakteri gram positif berbentuk batang, yang merupakan flora normal kulit, namun pada kondisi tertentu bakteri menimbulkan jerawat. Tujuan dari penelitian ini adalah untuk mengetahui berapakah konsentrasi minimum yang paling efektif ekstrak bawang merah sebagai gel antijerawat. Penelitian ini melakukan ekstraksi kulit bawang merah menggunakan metode maserasi dengan pelarut etanol 96%. Hasil rendemen dari ekstrak kulit bawang merah diperoleh sebesar 9,8%. Hasil ekstraksi diuji KHM kemudian hasil KHM digunakan untuk membuat formulasi gel. Pengujian daya hambat ekstrak kulit bawang merah dan sediaan gel ekstrak kulit bawang merah dilakukan dengan mengunakkan metode sumuran. Konsentrasi hambat minimum (KHM) yang menunjukkan daya hambat adalah 5% dengan rata-rata zona hambat 5,07mm. Kemudian dibuat sediaan gel dengan basis carbopol dan konsentrasi ekstrak sebesar 5% dan 10%. Formulasi terbaik dari sediaan gel yang dibuat adalah sediaan gel dengan konsentrasi ekstrak sebesar 10%. Konsentrasi ekstrak kulit bawang merah dalam sediaan gel antijerawat yang paling efektif dalam menghambat bakteri Propionibacterium acnes adalah sebesar 10% dengan zona hambat 10,50mm. Kata kunci: Gel, Kulit Bawang Merah, Antibakteri, Propionibacterium acnes
Clinical management of metastatic colorectal cancer in the era of precision medicine
Authors: Ciardiello Fortunato , Ciardiello Davide , Martini Giulia , Napolitano Stefania , Tabernero Josep , Cervantes Andres 
Published: April 2022

AbstractColorectal cancer (CRC) represents approximately 10% of all cancers and is the second most common cause of cancer deaths. Initial clinical presentation as metastatic CRC (mCRC) occurs in approximately 20% of patients. Moreover, up to 50% of patients with localized disease eventually develop metastases. Appropriate clinical management of these patients is still a challenging medical issue. Major efforts have been made to unveil the molecular landscape of mCRC. This has resulted in the identification of several druggable tumor molecular targets with the aim of developing personalized treatments for each patient. This review summarizes the improvements in the clinical management of patients with mCRC in the emerging era of precision medicine. In fact, molecular stratification, on which the current treatment algorithm for mCRC is based, although it does not completely represent the complexity of this disease, has been the first significant step toward clinically informative genetic profiling for implementing more effective therapeutic approaches. This has resulted in a clinically relevant increase in mCRC disease control and patient survival. The next steps in the clinical management of mCRC will be to integrate the comprehensive knowledge of tumor gene alterations, of tumor and microenvironment gene and protein expression profiling, of host immune competence as well as the application of the resulting dynamic changes to a precision medicine‐based continuum of care for each patient. This approach could result in the identification of individual prognostic and predictive parameters, which could help the clinician in choosing the most appropriate therapeutic program(s) throughout the entire disease journey for each patient with mCRC. CA Cancer J Clin. 2022;72:000‐000.
The Effect Of Black Tea (Camellia sinensis) Administration On Renal Histopathology Of Male White Rats (Rattus norvegicus) From Sprague Dawley Strain Induced By Used Cooking Oil
Authors: Taurina Hilda , Yuniar Jihan Vira , Yunita Elvira 
Published: April 2022

Used cooking oil is cooking oil that has been heated repeatedly, so that it can cause the formation of free radical compounds. Free radicals are toxic kidneys that generate cell injury via lipid peroxidation, DNA damage, and protein peroxidation. Black tea (Camellia sinensis) infusion has a strong polyphenol group, namely epigallocatechin gallate, thearubigin, theaflavin, the amino acid L-theanine, flavonols, and catechins that can inhibit free radicals and protect organs from oxidative stress. This study was a post-only control group design experiment. The research subjects used were 24 Sprague Dawley male rats which were divided into six groups. The first group was the control group (K0). Treatment group 1 was given distilled water and used cooking oil after 12 times heating (K1), treatment group 2 was given black tea at a dose of 2.5g/ kg bw (body weight) and distilled water (K2), and treatment group 3 was given black tea at a dose of 3.75 g/kg bw and distilled water (K3). Treatment group 4 was given used cooking oil after 12 times heating and black tea with a dose of 0.50 gr/200 gr bw (K4), treatment group 5 was given used cooking oil after 12 times heating and black tea with a dose of 3.75 g/kg bw (K5). All groups were treated for 42 days. Then, the rats' kidney was collected, and data were analyzed by Kruskal Wallis and One Way ANOVA test. The results of the Kruskal Wallis and One Way ANOVA test showed a decrease in glomerular and tubular damage after the rats orally induced with black tea were given 12x heating used cooking oil (p<0.05). The mean histopathological score in the administration of black tea at a dose of 3.75 g/kg bw was lower than at a dose of 2.5 g/kg bw. This study shows that infusion of black tea (Camellia sinensis) can prevent glomerular and tubular damage induced by used cooking oil.