bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multi‐objective hybrid evolutionary search algorithm for parallel production line balancing problem including disassembly and assembly tasks
Authors: Zhang Zeqiang , Zhu Lixia , Chen Yarong , Guan Chao 
Published: October 2022

AbstractThis paper proposes a multi‐objective hybrid evolutionary search algorithm to simultaneously optimize the number of workstations, the idle index and the quantity of the production equipment required for the parallel production line balancing problem including disassembly and assembly tasks. The proposed algorithm uses the crossover operation and the mutation operation to generate neighborhood individuals of the current evolutionary population. Based on the mixed population composed of the current evolutionary population and the newly generated neighborhood population, a novel population update method is developed. The individuals of the new generation population are composed of Pareto dominant individuals filtered from the mixed population and several individuals randomly selected from the dominated individuals. Then the local search strategy based on simulated annealing operation is applied to the new generation of population individuals to overcome the defect of premature convergence of the proposed algorithm. By solving test examples of different scales and comparing them with a variety of classical algorithms, the advantages in the aspects of the diversity, the convergence, and the distribution of the solution results of the proposed algorithm are proved. Finally, the established mathematical model and the developed algorithm are applied to the parallel production line designed for the bogie remanufacturing production line of a railway freight car maintenance company. The advantages of the parallel production line in improving the production efficiency and reducing the production cost are identified.
Progressive Taxation versus College Subsidies with College Dropout
Authors: MATSUDA KAZUSHIGE 
Published: October 2022

AbstractThis paper examines what the optimal policy is against the rising skill premium in a heterogeneous agent macroeconomic model in which agents make endogenous enrollment and dropout decisions. Some college enrollees in the model endogenously drop out after learning ability during college. Using this model, I derive the optimal progressive labor income tax and optimal college subsidies separately and compare the social welfare. While the effect of college subsidies is smaller than the case without learning ability, the optimal college subsidies improve social welfare more than the optimal progressive labor income tax.
Partial loss of arcuate kisspeptin neurons in female rats stimulates luteinizing hormone and decreases prolactin secretion induced by estradiol
Authors: Campideli‐Santana Ana C. , Gusmao Daniela O. , Almeida Fernanda R. C. L. , Araujo‐Lopes Roberta , Szawka Raphael E. 
Published: October 2022

AbstractKisspeptin, neurokinin, and dynorphin (KNDy) neurons in the arcuate nucleus (ARC) control luteinizing hormone (LH) and prolactin (PRL) release, although their role in conveying the effects of estradiol (E2) to these hormones is not well understood. We performed a longitudinal evaluation of female rats in which KNDy neurons were ablated using a neurokinin‐3 receptor agonist conjugated with saporin (NK3‐SAP) to investigate the impact of the reduction of KNDy neurons on the E2 regulation of gonadal and PRL axes. NK3‐SAP rats, bearing a moderate loss of ARC kisspeptin‐immunoreactive (‐IR) neurons (50%–90%), displayed irregular estrous cycles but essentially unaltered follicular development and a normal number of corpora lutea. Rats were then ovariectomized (OVX) and treated with a positive‐feedback dose of E2 (OVX + E2). LH and PRL were measured in the tail blood by an enzyme‐linked immunosorbent assay. The E2‐induced LH surge was amplified, whereas the PRL rise was decreased in NK3‐SAP rats compared to Blank‐SAP control. After 10 days of no hormonal treatment, basal LH levels were equally elevated in NK3‐SAP and controls. Tyrosine hydroxylase (TH) phosphorylation in the median eminence, in turn, was increased in NK3‐SAP rats, with no change in the number of ARC TH‐IR neurons. Thus, KNDy neurons exert concurrent and opposite roles in the E2‐induced surges of LH and PRL. The partial loss of KNDy neurons disrupts ovarian cyclicity but does not preclude ovulation, consistent with the disinhibition of the LH preovulatory surge. Conversely, KNDy neurons tonically inhibit the enzymatic activity of tuberoinfundibular dopaminergic neurons, which appears to facilitate PRL release in response to E2.
Treatment of bruising after injection to reduce cellulite
Authors: Gold Michael H. 
Published: October 2022

AbstractBackgroundCellulite 80%–98% of post‐pubertal women and results in cutaneous dimples in the affected area.AimsTherapies that target collagenous fibrous septae often provide successful outcomes.Materials & MethodsCollagenase clostridium histolyticum‐aaes (CCH) for injection consists of two collagenases which, under physiologic conditions, disrupt collagen structures by hydrolyzing Type I and III collagen.ResultsSubcutaneous CCH was approved in the United States in 2020 for the treatment of moderate‐to‐severe cellulite in the buttocks of adult women. Although bruising is primarily an aesthetic concern, a conspicuous procedure‐induced bruise may limit a patient's social activities and result in hesitation to undergo a similar cosmetic procedure in the future.ConclusionThe purpose of this review is to describe the available techniques for hastening bruise resolution and how they apply to resolving bruises associated with a CCH injectable.
Prehospital delay after acute ischemic stroke among Thai older adults: A cross‐sectional study
Authors: Butdee Sittirat , Juntasopeepun Phanida , Chintanawat Rojanee , Locsin Rozzano C. 
Published: October 2022

AbstractAcute ischemic stroke is a common medical emergency among older adults and requires immediate treatment. Prehospital delay limits the use of critical treatments, such as intravenous recombinant tissue plasminogen activators, leading to serious complications and often death. Using Andersen's Behavioral Model, this cross‐sectional study aimed to investigate and determine factors influencing prehospital delay among older persons with acute ischemic stroke. The participants consisted of 120 older persons with first‐time acute ischemic stroke diagnoses who received treatments at two hospitals in northern Thailand between November 2021 and February 2022. The results revealed that 70% of older persons experienced delays of over 3 hours following the onset of stroke symptoms. It was found that increased perceived severity of ischemic stroke and a shorter distance from home to the hospital were both associated with a reduced probability of prehospital delay. These findings highlight the significant factors influencing prehospital delay and suggest possible interventions to reduce prehospital delay among older patients with acute ischemic stroke.
What is wrong with the Mission Dependency Index for US federal infrastructure decisions?
Authors: Eisenberg Daniel A. , Fish Aaron B. , Alderson David L. 
Published: October 2022

AbstractThe Mission Dependency Index (MDI) is a risk metric used by US military services and federal agencies for guiding operations, management, and funding decisions for facilities. Despite its broad adoption for guiding the expenditure of billions in federal funds, several studies on MDI suggest it may have flaws that limit its efficacy. We present a detailed technical analysis of MDI to show how its flaws impact infrastructure decisions. We present the MDI used by the US Navy and develop a critique of current methods. We identify six problems with MDI that stem from its interpretation, use, and mathematical formulation, and we provide examples demonstrating how these flaws can bias decisions. We provide recommendations to overcome flaws for infrastructure risk decision making but ultimately recommend the US government develop a new metric less susceptible to bias.
Determining optimal locations for blood distribution centers
Authors: Wemelsfelder Merel L. , den Hertog Dick , Wisman Onno , Ihalainen Jarkko , Janssen Mart P. 
Published: October 2022

AbstractBackgroundBlood banks have to be thoughtful about supply chain decisions to effectively satisfy the blood product demand of hospitals. These decisions include the number and locations of distribution centers (DC), as this has a strong impact on both transportation cost and the ability to deliver emergency orders in time.Study Design and MethodsWe propose a mixed‐integer linear programming approach to find optimal DC locations for supplying individual hospitals. The model maximizes the number of hospitals reachable from a DC within a given time‐limit, and minimizes transportation cost. The minimal amount of data required is a set of hospital locations. The model can be further attuned to the user's needs by adding various model extensions. The model's use is demonstrated by two case studies, considering the blood banks of the Netherlands and Finland.ResultsFor both case studies re‐locating the DCs would result in a reduction of transportation cost of about 10% without affecting the reliability of delivery. In addition, to save facility exploitation costs, the number of DCs may be reduced in both countries while maintaining the reliability of delivery. The model was also shown to be robust against changes in hospital ordering behavior.DiscussionWe demonstrated the general usability and added value of the model by successfully optimizing the blood supply chains of the Netherlands and Finland, which differ substantially. Nonetheless, in both countries potential savings in both transportation and facility exploitation cost could be shown. The model code is open source and freely accessible online.
Mathematical model evaluating for degradation of azo dye in contaminated water by UV/persulfate process
Authors: DoustMohamadi Seyed Mohamad Mahdi , Vahedpour Morteza , Rasoulifard Mohammad Hossein , Heidari Azam 
Published: October 2022

AbstractIn the present study, the photooxidative degradation of Acid Red 14 (AR 14) was investigated in the UV/persulfate process, and the results of the degradation rate of AR 14 were parametrically represented by ordinary differential equations to find mathematical model for the degradation rate of AR 14 in this process. Our experimental observations led to a model for AR 14 degradation in the UV/persulfate system that could be used to predict removal efficiency by changes of S2O82− (X1) and dye concentration (X2), pH (X3), temperature (X4) and also distance of UV lamp from solution (X5). It was found that persulfate and dye concentrations were the most important parameters for AR 14 degradation rate. Moreover, the results showed that the degradation rate was in good agreement with the first‐order kinetics for all the parameter values studied. Moreover, the results of the mathematical model agree well with the experimental values (R2 = 0.96). Our findings in this study showed that degradation efficiency of UV/S2O82− process for AR 14 was obtained as 98%. Therefore, this model could be applicable before scaling up the AR 14 degradation using UV/persulfate process.
Oceanographic consequences of the Bransfield Strait (Antarctica) opening
Authors: Liu Shan , Hernández-Molina F. Javier , Yang Chupeng , Zhang Cuimei , Huang Xiaoxia , Yin Shaoru , García Marga , Van Rooij David , Wang Ce , Zhuo Haiteng , Chen Hui , Lei Yaping , Lin Zhixuan , Luo Kunwen , Su Ming 
Published: October 2022

Abstract
The Bransfield Strait (Antarctica) is an important region for evaluating changes in Weddell Sea shelf waters on geological time scales because of its restricted connections to the surrounding ocean. However, the detailed oceanographic consequences of the opening of the strait remain unclear. We present bottom-current-related sedimentary features in the Bransfield Strait and examine the impact of the strait’s opening on deep-water circulation. Our findings show that the ocean circulation started to resemble that of the present day after a period of volcanic activity, possibly around the Middle Pleistocene. Coeval changes in Bransfield Strait morphology and an increase in seafloor irregularities due to the formation of volcanic chains finally determined new pathways for the Bransfield deep and bottom waters, enhanced due to the new climatic scenario of 100 k.y. cycles. The fact that “modernlike” oceanic circulation occurred only during previous interglacial periods demonstrates the significant impact of 100 k.y. climate cycles on the thermohaline changes of Antarctic deep waters. Hence, establishing a modern-day circulation model would enable researchers to assess paleoproductivity and local upwelling that have profoundly influenced the marine ecosystem of the Antarctic Peninsula after the Middle Pleistocene.
Global Ba/Nb systematics in arc magmas reflect the depths of mineral dehydration in subducted slabs
Authors: Barber Nicholas D. , Edmonds Marie , Jenner Frances , Williams Helen 
Published: October 2022

Abstract
The transfer of material from subducting slabs to the overlying mantle is one of the most important processes regulating Earth’s geochemical cycles. A major part of this material cycling involves slab devolatilization and the release of sediment- and slab-derived fluids to the mantle wedge, triggering melting and subsequent arc volcanism. Previous geodynamic, geophysical, and geochemical studies have revealed many important controls on fluid fluxing to the mantle and its manifestations in arc magmas. However, it remains difficult to identify the specific mineral breakdown reactions that control element fluxes from the subducting slab into the overriding mantle. To address this challenge, we combine global arc whole-rock compositional data with geophysical information (e.g., depths to slab) and thermodynamic data. We observe three peaks in Ba/Nb in global arc magma whole-rock compositions corresponding to depths to slab of 60, 120, and &gt;290 km. Using published thermodynamic and geodynamic models of slab evolution, we show that these peaks can be linked to the progressive breakdown of hydrous minerals (e.g., epidote, actinolite, lawsonite) in subducting slabs.
Mobilization of tin during continental subduction-accretion processes
Authors: Romer Rolf L. , Kroner Uwe , Schmidt C. , Legler Claus 
Published: October 2022

Abstract
Major tin (Sn) deposits within the Variscan orogen are closely related to 325–270 Ma postkinematic granites that intruded the metamorphic rocks of the former precollisional accretionary wedge of the Gondwana margin. In the Erzgebirge (Germany), some of these metasedimentary rocks have high Sn contents (locally more than 1000 ppm Sn). We report cassiterite (SnO2) U-Pb ages of 395–365 Ma and high Sn contents in prograde biotite in these metasedimentary rocks. These data demonstrate that Sn was already introduced into these rocks during accretion and prograde metamorphism. Mobilization of Sn from sedimentary source rocks during prograde fluid loss in a subduction-accretion setting represents an important process of pre-enrichment of sedimentary source rocks that upon partial melting may produce Sn-enriched melts. The large-scale metamorphic mobilization of Sn, documented here for the first time, highlights the possible importance of metamorphic Sn enrichment in accretionary complexes, thereby explaining the spatial distribution of major Sn districts within the Variscan orogen.
Formal registration of visual impairment in people with diabetic retinopathy significantly underestimates the scale of the problem: a retrospective cohort study at a tertiary care eye hospital service in the UK
Authors: Olvera-Barrios Abraham , Mishra Amit V , Schwartz Roy , Khatun Mumina , Seltene Michael , Rutkowska Celestine , Rudnicka Alicja R , Owen Christopher G , Tufail Adnan , A Egan Catherine 
Published: October 2022

Aims
To analyse the prevalence of visual impairment (VI), compare it to certification of visual impairment (CVI) and analyse VI associations in patients with diabetic retinopathy (DR).

Methods
Retrospective cohort study, which included 8007 patients with DR referred from the English diabetic eye screening programme to a tertiary referral eye hospital. Main outcome measure was VI, defined as vision in the best eye of <6/24. We conducted a multivariable logistic regression for VI as primary outcome of interest, controlling for age, sex, type of diabetes, baseline DR grade, ethnicity and index of multiple deprivation (IMD).

Results

Mean age was 64.5 (SD 13.6) years; 61% of patients were men; and 31% of South Asian ethnicity. There were 68 patients with CVI during the study period, and 84% (272/325) of patients with VI did not have CVI after a mean follow-up of 1.87 (SD ±0.86) years. Older age showed a positive association with VI (OR per decade rise 1.88, 95% CI 1.70 to 2.08; p=1.8×10
–34
). Men had a lower risk of VI (OR 0.62, 95% CI 0.50 to 0.79, p=6.0×10
–5
), and less deprivation had a graded inverse association with VI (OR per IMD category increase 0.83, 95% CI 0.74 to 0.93, p value for linear trend 0.002).

Conclusion
The majority of people with vision impairment are not registered at the point of care, which could translate to underestimation of diabetes-related VI and all-cause VI at a national level if replicated at other centres. Further work is needed to explore rates of VI and uptake of registration.
Population-based investigation of common and deviating patterns of gastric cancer and oesophageal cancer incidence across populations and time
Authors: Li Mengmeng , Park Jin Young , Sheikh Mahdi , Kayamba Violet , Rumgay Harriet , Jenab Mazda , Narh Clement Tetteh , Abedi-Ardekani Behnoush , Morgan Eileen , de Martel Catherine , McCormack Valerie , Arnold Melina 
Published: October 2022

BackgroundThe subtypes of gastric cancer (GC) and oesophageal cancer (EC) manifest distinct epidemiological profiles. Here, we aim to examine correlations in their incidence rates and to compare their temporal changes globally, both overall and by subtype.MethodsLong-term incidence data were obtained from population-based registries available from the Cancer Incidence in Five Continents series. Variation in the occurrence of EC and GC (overall and by subtype) was assessed using the GC:EC ratio of sex-specific age-standardised rates (ASR) in 2008–2012. Average annual per cent changes were estimated to assess temporal trends during 1998–2012.ResultsASRs for GC and EC varied remarkably across and within world regions. In the countries evaluated, the GC:EC ratio in men exceeded 10 in several South American countries, Algeria and Republic of Korea, while EC dominated in most sub-Saharan African countries. High rates of both cardia gastric cancer and oesophageal squamous cell carcinoma (ESCC) were observed in several Asian populations. Non-cardia gastric cancer rates correlated positively with ESCC rates (r=0.60) and negatively with EAC (r=−0.79). For the time trends, while GC incidence has been uniformly decreasing by on average 2%–3% annually over 1998–2012 in most countries, trends for EC depend strongly on histology, with several but not all countries experiencing increases in EAC and decreases in ESCC.ConclusionsCorrelations between GC and EC incidence rates across populations are positive or inverse depending on the GC subsite and EC subtype. Multisite studies that include a combination of populations whose incidence rates follow and deviate from these patterns may be aetiologically informative.
MALAT1 promotes platelet activity and thrombus formation through PI3k/Akt/GSK-3β signalling pathway
Authors: Sun Yeying , Wang Tao , Lv Yan , Li Jiahua , Jiang Xiaoli , Jiang Jing , Zhang Daolai , Bian Weihua , Zhang Chunxiang 
Published: October 2022

BackgroundIschaemic stroke and other cardiovascular illnesses are characterised by abnormalities in the processes of thrombosis and haemostasis, which rely on platelet activity. In platelets, a wide variety of microRNAs (long non-coding RNA, lncRNAs) is found. Due to the absence of nuclear DNA in platelets, lncRNAs may serve as critical post-transcriptional regulators of platelet activities. However, research into the roles of lncRNAs in platelets is limited.ObjectiveThe purpose of this study is to learn more about the molecular mechanism by which MALAT1 affects platelet activity and thrombus formation.Methods/resultsThe CD34+megakaryocytes used in this research as an in vitro model for human megakaryocytes and platelets. Cell adhesion and spreading are enhanced in the absence and presence of agonists in CD34+megakaryocytes subjected to MALAT1 knockdown (KD). The adhesion and activity of platelet-like particles produced by MALAT1 KD cells are significantly enhanced at rest and after thrombin activation. Thrombus development on a collagen matrix is also greatly enhanced in the microfluidic whole-blood perfusion model: platelets lacking MALAT1 exhibit elevated accumulation, distributing area and activity. In addition, MALAT1-deficient mice bleed less and form a stable occlusive thrombus more quickly than wild-type mice. PTEN and PDK1 regulated the activity of MALAT1 in platelets to carry out its PI3k/Akt/GSK-3β signalling pathway-related function.ConclusionThe suppression of MALAT1 expression significantly increases platelet adhesion, spreading, platelet activity, and thrombus formation. lncRNAs may constitute a unique class of platelet function modulators.
Mapping the maximum peat thickness of cultivated organic soils in the southwest plain of Montreal
Authors: Deragon Raphaël , Saurette Daniel D. , Heung Brandon , Caron Jean 
Published: October 2022

Large organic deposits in the southwestern plain of Montreal have been converted to agricultural land for vegetable production. In addition to the variable depth of the organic deposits, these soils commonly have an impermeable coprogenous layer between the peat and the underlying mineral substratum. Estimations of the depth and thickness of these materials are critical for soil management. Therefore, five drained and cultivated peatlands were studied to estimate their maximum peat thickness (MPT)—a potential key soil property that can help identify management zones for their conservation. MPT can be defined as the depth to the mineral layer (DML) minus the coprogenous layer thickness (CLT). The objective of this study was to estimate DML, CLT, and MPT at a regional scale using environmental covariates derived from remote sensing. Three machine-learning models (Cubist, Random Forest, and k-Nearest Neighbor) were compared to produce maps of DML and CLT, which were combined to generate MPT at a spatial resolution of 10 m. The Cubist model performed the best for predicting both features of interest, yielding Lin’s concordance correlation coefficients of 0.43 and 0.07 for DML and CLT, respectively, using a spatial cross-validation procedure. Interpretation of the drivers of CLT was limited by the poor predictive power of the final model. More precise data on MPT are needed to support soil conservation practices, and more CLT field observations are required to obtain a higher prediction accuracy. Nonetheless, digital soil mapping using open-access geospatial data shows promise for understanding and managing cultivated peatlands.