bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioinformatics analysis and experimental verification of the prognostic and biological significance mediated by fatty acid metabolism related genes for hepatocellular carcinoma
Authors: Zhu Xiao-Ren , Zhu Jia-Qi , Chen Yu-Fei , Liu Yuan-Yuan , Lu Jing-Jing , Sun Jun , Peng Shi-Qing , Chen Min-Bin , Du Yi-Ping 
Published: August 2022

BackgroundLiver cancer is among the leading causes of death related to cancer around the world. The most frequent type of human liver cancer is hepatocellular carcinoma (HCC). Fatty acid (FA) metabolism is an emerging hallmark that plays a promoting role in numerous malignancies. This study aimed to discover a FA metabolism-related risk signature and formulate a better model for HCC patients’ prognosis prediction.MethodsWe collected mRNA expression data and clinical parameters of patients with HCC using the TCGA databases, and the differential FA metabolism-related genes were explored. To create a risk prognostic model, we carried out the consensus clustering as well as univariate and multivariate Cox regression analyses. 16 genes were used to establish a prognostic model, which was then validated in the ICGC dataset. The accuracy of the model was performed using receiver operating characteristic (ROC) analyses, decision curve analysis (DCA) and nomogram. The immune cell infiltration level of risk genes was evaluated with single-sample GSEA (ssGSEA) algorithm. To reflect the response to immunotherapy, immunophenoscore (IPS) was obtained from TCGA-LIHC. Then, the expression of the candidate risk genes (p &lt; 0.05) was validated by qRT-PCR, Western blotting and single-cell transcriptomics. Cellular function assays were performed to revealed the biological function of HAVCR1.ResultsAccording to the TCGA-LIHC cohort analysis, the majority of the FA metabolism-related genes were expressed differentially in the HCC and normal tissues. The prognosis of patients with high-risk scores was observed to be worse. Multivariate COX regression analysis confirmed that the model can be employed as an independent prognosis factor for HCC patients. Furthermore, ssGSEA analysis revealed a link between the model and the levels of immune cell infiltration. Our model scoring mechanism also provides a high predictive value in HCC patients receiving anti-PDL1 immunotherapy. One of the FA metabolism-related genes, HAVCR1, displays a significant differential expression between normal and HCC cell lines. Hepatocellular carcinoma cells (Huh7, and HepG2) proliferation, motility, and invasion were all remarkably inhibited by HAVCR1 siRNA.ConclusionOur study identified a novel FA metabolism-related prognostic model, revealing a better potential treatment and prevention strategy for HCC.
Comparison of characteristics between neuropathic pain and non-neuropathic pain in patients with diabetic carpal tunnel syndrome: A cross-sectional study
Authors: Liu Yingnan , Zhuang Yongqing , Wei Ruihong , Tan Zhouyong , Chen Chao , Yang Dazhi 
Published: August 2022

BackgroundThe aim of the study was to compare the clinical characteristics of diabetic carpal tunnel syndrome between patients with neuropathic pain (NeuP) and non-NeuP.MethodsWe enrolled 276 patients with diabetic carpal tunnel syndrome. Pain symptoms were evaluated using a visual analog scale. Douleur Neuropathique 4, the Neuropathic Pain Symptoms Inventory questionnaire, and the body map were used to assess neuropathic symptoms. Baseline information, clinical manifestations, electrophysiological test results, and psychological status were compared between the neuropathic pain (NeuP) and non-NeuP to identify the risk factor for NeuP occurrence.ResultsResults showed that the degree of pain was more severe in NeuP patients than in nociceptive pain patients (p = 0.025). The frequencies of light touch and pinprick were more pronounced in the NeuP group than in the non-NeuP group (light touch: p = 0.001; pinprick: p = 0.004). There were 48 and 27 NeuP patients with extramedian and proximal spread, respectively, whereas in the non-NeuP group, there were 11 and 9 patients, respectively (p = 0.03). Electrophysiological results showed that patients in the NeuP group exhibited greater sensory nerve conduction velocity impairment compared with the non-NeuP group (p = 0.033). Pain Catastrophizing Scale total scores of the NeuP group were significantly higher than those of the non-NeuP group (p = 0.006).ConclusionOf the 276 diabetic carpal tunnel syndrome patients studied, the majority had NeuP. Furthermore, light touch, electrophysiological test results, and psychological factors were found to be related to NeuP occurrence in patients with diabetic carpal tunnel syndrome.
Development of New Equations Predicting the Mortality Risk of Patients on Continuous RRT
Authors: Kang Min Woo , Tangri Navdeep , Kwon Soie , Li Lilin , Lee Hyeseung , Han Seung Seok , An Jung Nam , Lee Jeonghwan , Kim Dong Ki , Lim Chun Soo , Kim Yon Su , Kim Sejoong , Lee Jung Pyo ,   on behalf of the VENUS trial Investigators
Published: August 2022

Key Points

Predicting the risk of mortality in patients with CRRT is important for appropriate management, but is challenging.We developed equations for predicting the mortality risk of patients with CRRT, using patients’ clinical data.The newly developed equations showed superior performance to SOFA and APACHE II scores.

Background
Predicting the risk of death in patients admitted to the critical care unit facilitates appropriate management. In particular, among patients who are critically ill, patients with continuous RRT (CRRT) have high mortality, and predicting the mortality risk of these patients is difficult. The purpose of this study was to develop models for predicting the mortality risk of patients on CRRT and to validate the models externally.

Methods
A total of 699 adult patients with CRRT who participated in the VolumE maNagement Under body composition monitoring in critically ill patientS on CRRT (VENUS) trial and 1515 adult patients with CRRT in Seoul National University Hospital were selected as the development and validation cohorts, respectively. Using 11 predictor variables selected by the Cox proportional hazards model and clinical importance, equations predicting mortality within 7, 14, and 28 days were developed with development cohort data.

Results
The equation using 11 variables had area under the time-dependent receiver operating characteristic curve (AUROC) values of 0.75, 0.74, and 0.73 for predicting 7-, 14-, and 28-day mortality, respectively. All equations had significantly higher AUROCs than the Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation II (APACHE II) scores. The 11-variable equation was superior to the SOFA and APACHE II scores in the integrated discrimination index and net reclassification improvement analyses.

Conclusions
The newly developed equations for predicting CRRT patient mortality showed superior performance to the previous scoring systems, and they can help physicians manage patients.
Contra Morcillo: Peralta Barnuevo y la defensa del virrey
Authors: Zinni Mariana 
Published: August 2022

En 1720, don Diego Morcillo Rubio de Auñón, por entonces arzobispo de La Plata, fue nombrado por segunda vez virrey del Perú al finalizar el gobierno de Carmine Caracciollo, príncipe de Santo Buono. Durante su segundo mandato, Morcillo fue, a su vez, elevado al solio metropolitano, ostentando ambos poderes, el religioso, como arzobispo, y el político como virrey. Se publican varios panfletos acusándolo de severas irregularidades: malversación de fondos, nepotismo, ambición desmedida, corrupción, sobornos, etc. Pedro de Peralta Barnuevo, un intelectual criollo cercano al poder, asume la defensa del arzobispo produciendo dos textos: Templo de la Fama Vindicado ([1720] 1996) y Diálogo político. La Verdad y la Justicia ([1724] 1996). En este artículo examinaré ambos escritos, obras poco estudiadas de Peralta, y los artefactos retóricos que allí despliega en su doble función: la defensa de la autoridad virreinal y el posicionamiento retórico y performativo del intelectual criollo bajo el poder borbónico.
A Study of Cultural Values in Tolkappiyam
Authors: V Pothumani , T Kamali 
Published: August 2022

Habits are regular routines that Tamil people engage in. They became the norm as they continued to be followed in life. Among these, habits come through practice. Traditions are based on customs. As a result, culture developed from the aspects of life that serve as examples of morality to the outside world. Being nurtured, cultured, groomed, or rectified, cultivated, cultivated as a way of life. Value among them all refers to the idea that concepts serve as the foundation for individual thoughts. It reflects the typical behaviours and thoughts of the majority of people in a society. On the basis of this, it is clear that a society's cultural elements consist of its arts, beliefs, conventions, language, literature, values, etc. This article is a study on the way they are taken in the Tolkappiyam
CLINICAL AND LABORATORY SUBSTANTIALITY OF DETERMINATION OF VITAMIN D IN CHILDREN
Authors: Гизингер О.А. , Силкина Т.А. , Пешикова М.В. 
Published: August 2022

Распространенность недостаточности витамина D (ниже 20 нг/мл) колеблется от 30 до 40 среди здорового детского населения средней полосы России в летний период. Целью исследования стало изучение уровня витамина D у детей в возрасте 36 лет, постоянно проживающих в Уральском регионе, в период минимальной инсоляции. Результаты исследования указывают на низкую обеспеченность витамином D детей в возрасте 36 лет, проживающих в г. Челябинске. Дети в возрасте 36 лет представляют группу риска по гиповитаминозу D и должны быть обеспечены необходимым лабораторным мониторингом уровня витамина D и более высокой профилактической дозой витамина D круглогодично.
The prevalence of calcidiol deficiency (below 20 ng / ml) ranges from 30 to 40 among healthy children in central Russia during the summer period. The aim of the work is to study the level of vitamin D in children aged 36 years of age who permanently reside in the Ural region, of Chelyabinsk during the period of minimal insolation. The results of the study indicate a low availability of vitamin D in children aged 36 years living in the city of Chelyabinsk. Thus, children aged 36 years are at risk of hypovitaminosis D and should be provided with the necessary laboratory monitoring of vitamin D levels and a higher prophylactic dose of vitamin D yearround
Reducing Maternal Anxiety Levels Using Autogenic Relaxation During The Covid 19 Pandemic
Authors: Hardianti Dwi Cindy , Mediarti Devi , Hindun Siti 
Published: August 2022

ABSTRACT
Background: In Indonesia and even the world is experiencing the Coronavirus disease 2019 (COVID-19) pandemic. This can cause anxiety and have a negative impact on the psychology of pregnant women. Autogenic Relaxation is a form of mind body intervention, originating from within oneself that can make the mind calm, making motivational words or sentences done by imagining oneself in a calm and peaceful state, focusing on heart rate and breathing regulation can reduce anxiety levels pregnant women during the COVID-19 pandemic. Objective: To determine the Effect of Autogenic Relaxation Techniques on Anxiety Levels of Pregnant Women During the Covid-19 Pandemic At BPM Meli Rosita Palembang in 2021. Results: Statistical test results Anxiety levels before and after being given treatment with Autogenic relaxation techniques (Treatment Group) obtained p-value 0.001 (<0.05). The results of the Mann Whitney statistic test obtained a p value of 0.000 <0.05. With this it can be said that there is a difference in the Posttest of the treatment group and the control group. Because there is a significant difference, it can be said that "There is an effect of Autogenic Relaxation Techniques on the anxiety level of pregnant women during the Covid-19 pandemic at BPM Meli Rosita in 2021. Conclusion: There is an effect of Autogenic Relaxation Technique on the anxiety level of pregnant women during the Covid-19 pandemic at BPM Meli Rosita in 2021. Suggestion: It is hoped that the autogenic relaxation technique that has been done previously can be applied again routinely at home.

Keywords: Anxiety Levels, Autogenic Relaxation Techniques, Pregnant Women During the Covid-19 Pandemic
HUBUNGAN ANTARA LINGKUNGAN KELUARGA DAN PRILAKU KELUARGA DENGAN KEJADIAN TB PARU DI RSUD KAYUAGUNGTAHUN 2018
Authors: Ali Saidina , Karneli Karneli , Hermansyah Herry 
Published: August 2022

Latar Belakang: Penyakit tuberkulosis paru merupakan penyakit infeksi yang penyebarannya sangat mudah sekali yaitu: melalui batuk,bersin dan berbicara,Tujuan penelitian ini adalah untuk mengetahui hubungan antara lingkungan keluarga dan prilaku keluarga dengan kejadian Di RSUD Kayu Agung Pada Tahun 2018.
Metode penelitian bersifat Deskriptif dengan desain cross sectional. Penelitian ini dilakukan di RSUD Kayu Agung. Sampel dalam penelitian ini adalah pasien yang berobat di instalasi rawat jalan penyakit Di RSUD Kayu Agung.
Hasil penelitian dari semua populasi didaptkan 10 responden dengan persentase (33.3%) jumlah ini lebih kecil dibanding responden yang tidak terdiagnosa TB Paru dengan persentase (66.7%). Berdasarkan Lingkungan Keluarga yang tidak sehat sebanyak 10 responden dengan persentase (33.3%) jumlah ini lebih kecil dibanding responden Lingkungan Keluarga yang sehat dengan persentase (66.7%). berdasarkan Prilaku Keluarga buruk didapatkan persentase (36.7%), jumlah ini lebih kecil dibanding responden Prilaku Keluarga baik dengan persentase (63.3%). Berdasarkan uji chi square pada α=0.05 diperolehp value=0.005< α=0.05 maka menunjukan ada hubungan yang bermakna antara lingkungan keluarga dengan kejadian TB Paru.
Kesimpulan secara hipotesis menyatakan ada hubungan antara prilaku keluarga dengan kejadian TB Paru dan menyatakan ada hubungan antara lingkungan keluarga dengan kejadian TB Paru..
Kata kunci : TB Paru,Lingkungan keluarga, Prilaku keluarga
GAMBARAN KADAR KOLESTEROL TOTAL DOSEN DI PERGURUAN TINGGI KESEHATAN KOTA PALEMBANG
Authors: Amelia Regina , Asrori Asrori , Ibrahim Rivai 
Published: August 2022

Latar Belakang Kolesterol adalah salah satu senyawa lemak, berwarna kekuningan, yang dalam kadar normal sangat bermanfaat pada berbagai proses metabolisme dalam tubuh, antara lain untuk bahan pembentuk dinding sel, pembungkus jaringan saraf, membuat vitamin D untuk kesehatan tulang. Tujuan penelitian untuk mengetahui gambaran kadar kolesterol total pada dosen di perguruan tinggi kesehatan kota Palembang berdasarkan umur, jenis kelamin, aktivitas fisik dan indeks masa tubuh. Penelitian dilaksanakan di kampus Sukabangun Poltekkes Kemenkes Palembang. Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross sectional. Sampel penelitian adalah dosen Jurusan Analis Kesehatan dan Gizi dengan jumlah sampel 30 orang dosen. Hasil penelitian didapatkan kadar kolesterol total normal 36,7%, tidak normal 63,3%. Berdasarkan umur kategori berisiko, kadar kolesterol total normal 30,4%, tidak normal 69,6% dan kategori umur tidak berisiko, kadar kolesterol total normal 57,1%, tidak normal 42,9%. Berdasarkan jenis kelamin kategori laki-laki, kadar kolesterol total normal 42,9%, tidak normal 57,1% dan kategori perempuan, kadar kolesterol total normal 31,3%, tidak normal 63,3%. Berdasarkan aktivitas fisik kategori aktif, kadar kolesterol total normal 34,8%, tidak normal 65,2% dan aktifitas fisik kategori inaktif, kadar kolesterol total normal 42,9%, tidak normal 57,1%. Berdasarkan IMT kategori normal, kadar kolesterol normal 29,2%, tidak normal 17 70,8% dan IMT kategori gemuk, kadar kolesterol total normal 66,7%, tidak normal 33,3%. Disarankan pada dosen yang memiliki kadar kolesterol total tinggi agar mengurangi makan makanan berlemak dan rutin berolahraga.
Kata Kunci : Dosen, Kolesterol Total, Palembang
Mengukur Nilai Potensi Ekonomi Taman Rekreasi Sengkaling UMM
Authors: Pramuja Risky Angga , Malik Nazaruddin , Supiandi Supiandi , Yuli Sri Budi Cantika , Arifin Zainal 
Published: August 2022

Travel Cost Method adalah suatu cara untuk mengestimasi kerelaan membayar individu pengunjung untuk jasa-jasa sumber daya alam dan lingkungan. Valuasi Ekonomi adalah suatu proses mengestimasi nilai moneter dari barang dan jasa yang diberikan oleh suatu tempat atas manfaat yang diberikan. Nilai Ekonomi adalah pengukuran jumlah maksimum individu mengorbankan barang dan jasa untuk memperoleh barang jasa yang lain. Hal itu disebut keinginan membayar (willingness to pay ) terhadap barang dan jasa yang dihasilkan dari sumber daya alam dan lingkungan.Nilai ekonomi Taman Rekreasi Sengkaling sebesar Rp2.113.841.500.000. Dengan nilai akuisisi future value tahun 2022 sebesar Rp359.291.248.095, Taman Rekreasi Sengkaling memiliki nilai potensi lebih besar yaitu sebesar Rp2.113.841.500.000. Maka nilai pembelian Taman Rekreasi Sengkaling oleh pihak Universitas Muhammadiyah Malang dari PT. Bentoel Group di bawah nilai ekonomi atau nilai potensinya.
Pengabaian Nafkah Anak Pascaperceraian Orang tua Sebagai Penelantaran Anak
Authors: Sari Amitri Dinar 
Published: August 2022

This article aims to explain child support omission during the post-divorce proceeding as child negligence, which causes children’s victimization. This research uses literature studies from several books, journals, articles, documents and other related materials. The data was collected from ten scientific articles, eight scientific books, one seminar paper and three internet articles. The results have shown that child support negligence after parental divorced is a form of child neglect that will impact children’s victimizations and their welfare. This article uses an Ecological Theoryapproach to examine the occurrence of child support negligence by a father. (10 pt)Artikel ini mengkaji tentang pengabaian nafkah anak pascaperceraian orang tua oleh pihak ayah sebagai penelantaran anak. Selain itu, artikel ini juga menjelaskan bahwa penelantaran anak menyebabkan anak mengalami viktimisasi. Penelitian ini menggunakan studi kepustakaan dengan beberapa sumber bacaan dari buku-buku, artikel-artikel jurnal, dokumen-dokumen, dan bahan-bahan lainnya yang terkait dengan isu di dalam artikel ini. Sumber data bersumber dari sepuluh artikel dari jurnal ilmiah, delapan buku ilmiah, satu makalah seminar dan tiga artikel internet. Hasil penelitian di dalam artikel ini adalah, menjelaskan bahwa pengabaian nafkah anak pascaperceraian orang tua adalah salah satu bentuk dari penelantaran anak, karena menyebabkan anak mengalami viktimisasi sehingga menganggu kesejahteraan anak. Artikel ini menggunakan pendekatan Ecological Theory untuk mengkaji terjadinya penelantaran nafkah anak akibat perceraian orang tua oleh pihak ayah. (10 pt).
Komunikasi Antar Budaya Pasangan Kawin Campur di Indonesia
Authors: Budyanto Chrestella , Sari Marchelia Pamela , Diamanta Nadhira Puspa 
Published: August 2022

As the world opens up and multicultural interactions increases, the same applies to intercultural relationships. In Indonesia, especially in the capital of Jakarta, people from different backgrounds of culture even countries are often met and some, fall in love. The study aims to understand and discover how individuals married to someone who is from different culture live, and the process of intercultural communication happen in an intimate relationship of a marriage. The study uses qualitative methodology with interpretive paradigm. The result of the study shows intercultural marriages comes with just as many conflicts as in a monoculture marriage, but requires extra patience due to the different basic perspectives in approaching conflicts, and takes more time to adapt for the culture to assimilate to each other's. As the world opens up and multicultural interactions increases, the same applies to intercultural relationships. In Indonesia, especially in the capital of Jakarta, people from different backgrounds of culture even countries are often met and some, fall in love. The study aims to understand and discover how individuals married to someone who is from different culture live, and the process of intercultural communication happen in an intimate relationship of a marriage. The study uses qualitative methodology with interpretive paradigm. The result of the study shows intercultural marriages comes with just as many conflicts as in a monoculture marriage, but requires extra patience due to the different basic perspectives in approaching conflicts, and takes more time to adapt for the culture to assimilate to each other's.
Pelaksanaan Deradikalisasi Oleh Badan Nasional Penanggulangan Terorisme Dalam Pencegahan Pengulangan Tindak Pidana Terorisme
Authors: Purba Dody Prihatman 
Published: August 2022

Penelitian yang dilakukan oleh penulis memiliki tujuan untuk mengetahui dan menganalisis kendala-kendala yang dihadapi oleh Badan Nasional Penanggulangan Terorisme (BNPT) dalam pelaksanaan deradikalisasi terhadap narapidana tindak pidana terorisme, mengetahui dan menganalisis relevansi pelaksanaan deradikalisasi narapidana tindak pidana terorisme terhadap pencegahan pengulangan Tindak Pidana Terorisme serta mengkaji dan merumuskan pelaksanaan deradikalisasi dalam pencegahan pengulangan Tindak Pidana Terorisme di masa yang akan datang. Metode penelitian yang digunakan dalam tesis ini adalah metode penelitian normatif empiris karena penelitian ini dilakukan dengan cara mengkaji dan mendeskripsikan bahan-bahan pustaka, yang berupa litertaur, perundang-undangan dan dikaitkan dengan hasil wawancara narasumber dan responden yang memiliki kaitan dengan permasalahan yang akan dibahas. Metode analisis data yang digunakan dalam penelitian ini adalah analisis kualitatif, yaitu uraian data secara bermutu dalam bentuk kalimat yang teratur, runtun, logis dan tidak tumpang tindih sehingga memudahkan implementasi data dan pemahaman hasil analisis. Hasil penelitian menunjukkan bahwa pelaksanaan deradikalisasi pada dasarnya berangkat dari asumsi bahwa terorisme berawal dari radikalisme sehingga upaya memerangi terorisme lebih efektif melalui deradikalisasi. Namun tidak dapat dipungkiri adanya fakta beberapa mantan napi terorisme yang kembali melakukan aksi teror selepas menjalani hukuman di lapas. Dilihat dari mantan narapidana terorisme yang sukses ketika kembali ke masyarakat maka dapat dikatakan bahwa pelaksanaan deradikalisasi sukses, akan tetapi bila dilihat dari mantan narapidana terorisme yang kembali mengulangi perbuatan tindak pidana terorisme maka pelaksanaan deradikalisasi belum berjalan baik. deradikalisasi merupakan upaya pencegahan kejatan secara penal karena dengan pemidanaan menjadi pintu masuk untuk pelaksanaan deradikalisasi sebab deradikalisasi dilakukan terhadap orang yang sudah terlibat dalam tindak pidana terorisme dan mendapatkan putusan yang telah inkracht sehingga mendapatkan program deradikalisasi. Melalui sistem peradilan pidana, pelaksanaan deradikalisasi merupakan pencegahan kejahatan dengan upaya penal yang dilakukan secara berkesinambungan untuk dapat mencegah mantan narapidana terorisme mengulangi tindak pidana terorisme