bluuebunny/crossref_metadata_2025_split huggingface dataset:
​Effect of Germination on the Physical and Functional Properties of Brown Rice Flours
Authors: Mohmmed Naseerunnisa , Kuna Aparna , Sarkar Supta , Azam M.M. , Prasanna K. Lakshmi 
Published: March 2022

Background: Germinated brown rice (GBR) flour recently gained popularity due to its nutritional and health-promoting benefits and is being used as a functional ingredient in formulation of various food products, replacing rice flour. GBR is prepared by soaking brown rice (BR), more specifically, the embryo of brown rice in water to promote grain activation under controlled conditions. Methods: Present study was aimed to develop the GBR flours of MTU 1010 and KNM 118 at various germination hours (0, 12, 24, 36, 48 and 72 hours) and to study the effect of germination on the physical and functional properties of BR and GBR flours. Result: Our findings revealed that germination showed significant variations in l*, a*, b* and DE* of BR flours of both varieties. Germination significantly decreased the bulk density, tapped density, oil absorption capacity, water activity. Germination also considerably improved the water absorption capacity at 24 hours of germination and foaming capacity of MTU 1010 and KNM 118 GBR flours. BR flour had the least gelation concentration (LGC) of 8% and 6% which increased to 12% and 10% after 24 h germination in MTU 1010 and KNM 118 GBR flours, respectively.
DNA Polymorphisms in 3ʹUTR and Intron-9 Region of PPARGC1A Gene and its Association with Milk Production Traits in Gaolao Cattle
Authors: Sathe Y.B. , Kale D.S. , Singh Jaya , Patil D.V. , Koringa P.G. , Korde J.P. , Jawale M.R. 
Published: March 2022

Background: PPARGC1A gene mediates expression of genes involved in gluconeogenesis and is regarded as a prominent candidate gene governing the effect of milk fat in dairy bovines. The study was planned to identify DNA polymorphisms in the PPARGC1A gene in Gaolao Cattle and to find their association with milk production traits in Gaolao cattle. Methods: The blood was collected from 224 purebred Gaolao cattle from farm and field along with test day milk from each cow for estimating milk components. Genomic DNA was assessed using phenol-chloroform extraction method and Kits. PCR-RFLP, PCR-SSCP and direct DNA sequencing methods were used to identify polymorphism. Result: PPARGC1AG1- NheI locus of 3ʹUTR region were polymorphic with allele frequency for A alleles as 0.84 and for allele B as 0.16. In studied animals, significant differences were not observed for milk traits between genotypes at PPARGC1A-NheI locus. The analysis at PPARGC1AG4-SSCP revealed no significant differences in milk traits; however sequencing revealed SNP. PPARGC1AG1- NheI genotype-based sequencing revealed T greater than C SNP at 263rd position 02 computational SNPs viz; C-T at 263rd position and A-T at 268th position. The identified variation at the PPARGC1A gene may aid in identifying associations for development of markers for selection and genetic improvement.
Parental involvement in Kosovar education: Relationships with gender, education and employment variables
Authors: Turtulla Sermin , Lopar Elsev Brina 
Published: March 2022

This article aims to make an initial probe into parent involvement in children’s academic-related activities and how this is affected by the parents’ gender, education and employment variables. Most of the articles written on parental academic support focus on corroborating the positive relationship of parental involvement with student school achievement and cover samples from countries other than Kosova. This is the first correlational study which aims to show the significance of relationships of the specific demographic variables of Kosovar parents and the frequency of their homework help. Data are analysed using frequency distribution and chi-square for the correlation significance. The findings corroborate a higher percentage of females in parental involvement, and a negative correlation of parental involvement with employment and level of education. Implications and explanations for future research and practice are discussed.
Keywords: Academic success, homework help, Kosovar education, parent involvement, primary level.
Results of actualization learning basic training participants and evaluation of performance trainer and committee
Authors: Mardiningsih Heni , Mutohir Toho Cholik , Roesminingsih Erny 
Published: March 2022

This research is intended to to analyze the differences in the actualization of essential training participants on gender, position, and education level of prospective civil servant participants. The second objective is to analyze the assessment of resource persons and the committee's performance during the basic training process. This research used a quantitative-descriptive method to explain the data obtained through the actualization of Civil Servant Candidates. The sample was selected using the purposive sampling technique. The total participant was 50 candidates for Civil Servants (32 males and 18 females). The results of participants’ actualization were analyzed using two-way ANOVA analysis. This research shows significant differences in the actualization of male and female participants. The score of male participants is better than the score of female participants on the actualization of education. Then the results of the actualization of prospective civil servant participants who chose the formation of lecturers and teachers were no different, and the actualization of candidates for civil servants with graduates at the undergraduate, masters, and doctoral levels was no different. Furthermore, the performance of the trainers and committee during the basic training was very satisfactory, which was assessed by the participants.

Keywords: Actualization learning; basic training; civil servant candidates; performance committee; performance trainers
Delayed versus on arrival modified live viral vaccination in stocker cattle on bovine respiratory disease
Authors: Ambs Ashlee , Capik Sarah , Moberly Heather 
Published: March 2022

PICO question
In auction market calves at high risk of developing bovine respiratory disease (BRD), does delayed (14–30 days) vaccination with a modified live vaccine (MLV) for viral respiratory pathogens versus administration of MLV on arrival (within 24 hours of arrival) to the stocker operation, result in less calves with BRD morbidity diagnosed based on visual signs and rectal temperature >40°C, or less calves with BRD mortality?

Clinical bottom line
Category of research question
Treatment
The number and type of study designs reviewed
Four papers were critically reviewed. All were randomised complete block designs
Strength of evidence
Moderate
Outcomes reported
In stocker calves, delaying administration of a MLV for respiratory viruses may result in numerically lower initial BRD morbidity rates, while giving at arrival may result in numerically lower BRD retreatments. One study shows statistically lower cases of BRD morbidity after the third antimicrobial treatment in cattle vaccinated on arrival with both a clostridial and MLV for respiratory viruses compared to cattle vaccinated on arrival with clostridial vaccine and delayed MLV for respiratory viruses. No conclusion about mortality can be drawn due to inconsistent numerical conclusions between studies
Conclusion
Due to conflicting evidence and a general lack of statistically significant differences in morbidity and mortality outcomes, a definite answer regarding the impact of delayed MLV respiratory vaccination in stocker calves cannot be made

How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
EFFECT OF PRODUCT, PRICE, PROMOTION, DISTRIBUTION CHANNEL, AND SERVICE QUALITY ON PURCHASE DECISION
Authors: Agusfianto Nendy Pratama , Bairizki Ahmad 
Published: March 2022

This study aimed at investigating the effect of product, price, promotion, distribution channel, and service partially on the purchase decision for brick craft at one of MSMEs named UD Maju Terus in Giri Sasak and to finding out the variabel which having the most dominant effect on the purchase decision.
This study used an associative research model. The population in it were all customers of UD Maju Terus. The sampel of this study was as many 60 respondents. The sampel was drawn using purposive sampling technique. The data were gathered by distributing closed questionnaires using Likert scale. They were analysed using multiple liniear regression method. The partial effect were tested by using t-test while the most dominant effect were tested by using Dominant Test (Standardized Coefficient Beta).
The result of study tested partially showed that Product (X1), Price (X2). Promotion (X3), Distribution Channel (X4), Service Quality (X5), had significant effects on the purchase decision at UD Maju Terus. This was shown by t-test results where each variabel had a t-count value greater than t-table value. The distribution channel (X4) was the most dominant variable affecting the purchase decision for brick craft at UD Maju Terus, Giri Sasak. The result of the regression equation in this study was Y = 0,0358 + 0,0181 X1 + 0,252 X2 + 0,213 X3 + 0, 284 X4 + 0,165 X5
UPAYA MENINGKATKAN JUMLAH NASABAH MELALUI PENINGKATAN KUALITAS PELAYANAN PADA ASURANSI BUMI PUTERA CABANG MATARAM 2021
Authors: Wirastomo Handoyo , Maniza Lalu Hendra 
Published: March 2022

Abstrak
Dalam Asuransi Bumi Putera Cabang Mataram upaya dalam meningkatkan mutu pelayanan pada nasabah dibedakan menjadi dua yaitu dalam ruang lingkup perusahaan dan diluar lingkup perusahaan. Pemberian pelayanan yang baik sangat penting dilakukan oleh setiap perusahaan. Karena dengan pemberian pelayanan yang baik maka secara otomatis akan meningkatkan citra dan dapat dipercaya oleh para pelanggan atau para nasabah.
Guna meningkatkan kualitas serta keberhasilan yang ingin dicapai oleh Asuransi Bumi Putera Cabang Mataram selain upaya dalam meningkatkan mutu pelayanan pada nasabah juga perlu diketahui cara-cara Asuransi Bumi Putera Cabang Mataram dalam memberikan pelayanannya pada nasabah. Dalam hal ini karyawan dan juga penagih harus berusaha dengan baik dalam meningkatkan pelayanan bagi nasabahnya. Penagih dan pegawai harus berkomunikasi dengan baik karena mereka yang biasa berhadapan langsung dengan para nasabah. Cara pemberian pelayanan Asuransi Bumi Putera Cabang Mataram dapat dilakukan melalui pelayanan yang diberikan secara langsung dan pelayanan yang tidak langsung diberikan kepada nasabah.
Kata Kunci : Asuransi, Kualitas, Pelayanan
Special Issue on Self-Optimizing Machining Systems
Authors: Kakinuma Yasuhiro , Kono Daisuke 
Published: March 2022

The concept of Self-Optimizing Machining Systems (SOMS) has been proposed against the background of Industry 4.0 and the Digital Twin concept, based on cyber-physical systems. In order to improve manufacturing productivity, quality, and efficiency, each component technology related to the machining process, such as CAD/CAM, process modeling/simulation, process monitoring/control, and workpiece assessment, as well as the machine tools themselves, has been developed independently to date. However, series of processes, including the interactions among these component technologies, have finally determined the machining performance and the quality of the products. SOMS deals with the information links among these components comprehensively and plays the important role of combining these links and functionalities to optimize the overall machining system. Nevertheless, an intensive implementation and combination of these technologies has yet to become state-of-the-art in industry, while further research and development for SOMS is required for Industry 4.0 and Digital Twin.
This special issue focuses on the research trends of SOMS, especially the interaction links among machine tools, process monitoring, and work assessment. From researchers who are active on the front lines of manufacturing engineering, the latest achievements related to the development of SOMS are presented in 6 papers. On one hand, the development of sensor-integrated components is indispensable for SOMS to monitor the status of a process and feed it back to a related component in order to control the machining process and its environment. On the other hand, it can be said that visual simulation, virtual metrology, and other epoch-making, on-machine technologies for evaluating machined surfaces, as well as process optimization based on machined surface information, are strongly required.
We hope this special issue will contribute to future research and development for researchers and engineers in the field of manufacturing and machining systems.
Comparative Study on Particle Size Effect of Crushable Granular Soils through DEM Simulations
Authors: Wang Zi-Yi , Fang Yu-Fei , Feng Wei-Qiang , Tian Xiao-Jun , Lin Jian-Fu 
Published: March 2022

Abstract
The particle size plays an important role in the mechanical behavior of granular geomaterials. With respect to the crushable granular soils, the particle breakage under different pressures leads to the variation of the particle size distribution of soils. Therefore, it is essential to accurately model the particle fracture process to reproduce the key response of granular soils in the simulation. In this study, two simulated approaches, cluster method and replacement method, were performed to investigate the particle size effect for the crushable granular soils by three-dimensional (3D) discrete element method (DEM). DEM simulations were validated through the available results of diametric and oedometric compression tests with the help of the Weibull statistics. Based on the evaluation at particle and assemble-scale, it is found that both the cluster method and replacement method could simulate the particle strength and size dependence of sample failure with a good agreement with experimental results. The particle breakage phenomenon is also successfully modeled in DEM simulation and analyzed by the breakage index. Meanwhile, the computational efficiency was analyzed compared with two simulated methods. The findings in this study can provide a viable approach to investigate the particle breakage effect of the crushable geomaterials.
Method for laparoscopic transgastral resection for mesenchimal gastric tumors
Authors: Kamalov A. K. , Ryabov A. B. , Khomyakov V. M. , Volchenko N. N. , Kolobaev I. V. , Kostrygin A. K. , Aksenov S. A. 
Published: March 2022

The purpose of the study was to evaluate the efficacy and safety of laparoscopic transgastric resection for mesenchymal tumors of the proximal stomach.Material and Methods. A retrospective-prospective study was carried out. Surgical techniques of laparoscopic transgastric resection and the history of the development of this surgical method were described in detail. A total of 11 laparoscopic transgastric resections were performed. The course of the postoperative period and the postoperative management of patients were described. The immediate and long-term results of surgical treatment and the quality of life of patients were presented.Results. The assessment of the quality of life of patients after surgery showed that there were no cases of gastroesophageal reflux disease compared to proximal subtotal resection of the stomach or endoscopic tunnel resection. All patients underwent radical resection. In our study, we did not encounter cases of conversion of the surgical approach, as well as serious postoperative complications (Clavien–Dindo>III ). The analysis of long-term treatment outcomes showed that there were no cases of recurrence or disease progression. All patients are alive and followed up.Conclusion. This technique is fully justified, with careful selection of patients and compliance with all the rules of surgical oncology. Transgastric resection of gastric mesenchymal tumors located in the region of the cardioesophageal junction is a justified and safe technique. Surgery is performed under clear visual control, EGDS is not required to detect the tumor. This method allows the reduction of the frequency of contamination of the gastric flora into the abdominal cavity as well as the reduction of the wound area of the anterior abdominal wall.
Heat stress stimulates colon cancer cells to secret specific population of extracellular nanovesicles enriched by HSP70 and microRNAs
Authors: Nazarova I. V. , Zabegina L. M. , Nikiforova N. S. , Slusarenko M. A. , Sidina E. I. , Zhakhov A. V. , Ishchenko A. M. , Margulis B. A. , Guzhova I. V. , Malek A. V. 
Published: March 2022

Background. Heat stress (HS) induces the cellular secretion of heat shock proteins (HSP ) and extracellular nanovesicles (ENVs). The biological link between these phenomena is poorly understood. In the case of colorectal cancer (CRC) cells, the secretion of HSP s and ENV may be involved in the clinical response to intraperitoneal therapy of peritoneal carcinomatosis.Material and Methods. Established colon cancer cell lines COLO 320, HCT 116, HT29 and DLD 1 were used. ENVs were isolated from culture media by differential ultra-centrifugation and analyzed by dynamic light scattering, nanoparticle tracking analysis, atomic force microscopy and flow cytometry. Super-paramagnetic particles (SPMP ) covered by antibodies to the membrane form of Hsp70 were used for isolation and quantification of Hsp70(+) ENVs. Vesicular microRNA was assayed by RT-qPC R.Results. HS induces the secretion of ENVs by CRC cells, the resistance to HS correlates with the activity of HS-induced ENVs secretion. HS induces the secretion of a specific population of ENVs enriched by membrane form Hsp70 (mHsp70). The microRNA content of mHsp70(+) ENVs has qualitative and quantitative features. The concentration of miR-126-3p, -181-5p, -155-5p, -223 is increased in mHSP 70(+) ENVs secreted by three CRC cell lines.Conclusion. HS induces the secretion of mHSP 70(+) ENVs by CRC cells. This phenomenon may be involved in a clinical response to intraperitoneal chemo-hyperthermic perfusion therapy of peritoneal carcinomatosis.
Establishment of an orthotopic tumor model in the mammary gland of BALB/C nude mice using human breast cancer MCF-7 cells and their VDAC-deficient derivatives
Authors: Mndlyan E. Yu. , Semushina S. G. , Rzhevsky D. I. , Novikova N. I. , Kalabina E. A. , Komkov D. S. , Maslennikova A. Yu. , Murashev A. N. , Holmuhamedov E. L. 
Published: March 2022

Purpose to study the tumor-forming activity of wild-type MC F-7 cells carrying a full set of porins (VDAC 1, VDAC 2, VDAC 3), as well as their genetically modified cells, from which one of the isoforms was removed (MC F-7 VDAC 1 KO, MC F-7 VDAC 2 KO, MC F -7 VDAC 3 KO).Material and Methods. The study was aimed at establishing of an animal model of orthotopic tumors in the mammary gland of immunodeficient BAL B/c nude mice by implanting a suspension of human breast cancer cells (MC F-7) and derivatives of these cells generated by targeted knockout of one of the selected mitochondrial porin isoforms (VDAC 1, VDAC 2 or VDAC 3). Suspensions of either wild-type MC F-7 cell lines containing all three porin isoforms (VDAC 1, VDAC 2 and VDAC 3) or their VDAC -deficient derivatives (MC F-7 VDAC 1 KO, MC F-7 VDAC 2 KO and MC F-7 VDAC 3 KO) were injected into mammary fat pads of BAL B/c nude mice at a dose of 4x106 cells per injection. A pathomorphological analysis of the place of implantation of tumor cells, the tumor itself, as well as the organs of the abdominal and thoracic cavity was carried out.Results. The study shows the feasibility of successful creation of orthotopic tumors in the adipose tissue of immunodeficient BAL B/c nude mice with MC F-7 human breast cancer epithelial cells containing a complete set of mitochondrial porin isoforms and their VDAC -deficient derivatives. The tumor-forming activity of the implanted cells was shown to correlate with their cytotoxic effect on the internal organs of animals. Pathological analysis showed that all implanted cell cultures, such as MC F-7 WT, MC F-7 VDAC 2 KO and MC F-7 VDAC 3 KO, except for MC F-7 VDAC 1 KO cells, which did not form tumors, caused pathological changes in the lungs, liver and spleen, as well as the presence of other tumor-like lesions.Conclusion. The data obtained will be used to optimize the injection volume and cell number, as well as to refine the dynamics of tumor growth, suitable for studying the effect of anticancer drugs on tumors formed by human breast cancer cells (MC F-7) and its genetically modified VDAC -deficient derivatives.
Combination treatmnet of breast cancer patients during the COVID-19 pandemic
Authors: Kaprin A. D. , Zakiryakhodzhaev A. D. , Bosieva A. R. , Samsonov Yu. V. , Kostin A. A. 
Published: March 2022

The aim of the study was to analyze the most significant studies representing the basic principles of diagnosis and treatment of patients with breast cancer (BC) during the CO VID -19 pandemic.Material and Methods. The search for relevant sources was carried out in PubMed, Cochrane Library, Web of Science systems, publications for 2019–2020 were studied, 48 of which were used to write this review.Results. During the CO VID -19 pandemic, it is necessary to suspend screening examinations for a certain period of time; patients with early and metastatic breast cancer should be transferred to outpatient treatment in the LU s located in their place of residence. Examinations and consultations of patients undergoing hormone therapy should be postponed or carried out using telemedicine technologies. Treatment of breast cancer patients during a pandemic should be carried out according to clinical guidelines and protocols, but minimizing the number of visits to the hospitals.Conclusion. The pandemic of the novel coronavirus infection (CO VID -19) is a serious problem for healthcare and professionals around the world. All treatment decisions must be based on risks and benefits in the context of each stage of the pandemic, on an individual basis and taking into account the preferences of patients.
EXCLUSÃO COMO DISPOSITIVO
Authors: Pinheiro Ramos de Souza Fábio , Sepulveda Denize 
Published: March 2022

Esse artigo resulta de uma pesquisa de mestrado e objetivou desenlvover uma análise sobre as articulações que envolvem a exclusão social no processo de expulsão escolar de mulheres trans e travestis. Através de uma revisão bibliográfica sobre a temática foi possível realizar uma construção de entendimento entre os conceitos de “evasão” e “expulsão” e compreender como a exclusão social funciona como um dispositivo chave da resultante em questão. A expulsão escolar apresentou-se como um problema que muitas vezes pode ser entendido como fator generalista de “desistência” do percurso escolar. É importanta destacar, também, que a formação desse processo de exclusão pode ser compreendida como multiplas e complementares. No entanto, observado as suas caracteríticas específicas como o recorte de gênero, a exclusão social se mostra como mecanismo central para compreendermos a expulsão. Desse modo, entendendo o curriculos escolar como base para compreender o que acontece nas jornadas escolares trans, foi possível destrinchar as nuances que corroboram para que esse problema social perdure nas escolas brasileiras.