bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-traumatic Osteoarthritis: The Worst Associated Injuries and Differences in Patients' Profile When Compared With Primary Osteoarthritis
Authors: Maia Catrine Rangel , Annichino Ricardo Fruschein , Munhoz Marcelo de Azevedo e Souza , Machado Eduardo Gomes , Marchi Evaldo , Castano-Betancourt Martha Cecilia 
Published: May 2022

Abstract
Background: Between 10-12% of all osteoarthritis cases are classified as post-traumatic. Patients with post-traumatic osteoarthritis (PTOA) have a higher risk for complications after total joint arthroplasty than patients with primary OA; however, the possible causes remain unknown. A profile of patients with PTOA, more disabling injuries and comorbidities compared to patients with primary OA might help to elucidate. This work aims 1) to identify the most common past injuries associated with the most painful and disabling PTOA cases in a group of non-athlete patients and 2) compare the comorbidities and characteristics between PTOA and primary OA cases. Methods. Retrospective hospital-based cohort study with 1290 participants with joint complaints or who received arthroplasty. Medical records included demographic information, diagnosis, medication, smoking, alcohol history and comorbidities. Information from the orthopaedic consult included the type and date of injury (for PTOA), pain score by the numerical rating scale (NRS) and walking disability. Results. There were 641 cases with primary OA (65% females) and 104 with PTOA (61% males). Patients with PTOA were 7.5 years younger (P<0.001), reported more alcohol consumption (P=0.01) and had higher odds of osteoporotic fractures and bipolar disorder or schizophrenia than patients with primary OA (OR= 2.0, CI=1.06-3.78 and OR=2.90, CI=-0.91-9.18, respectively). Knee fractures were most common in males and hip fractures in females (31% and 37.5%, respectively, P<0.005). The PTOA-associated injuries with the highest pain and disability scores were meniscal injuries and hip fractures (NRS=8.3/10, (P-ANOVA=0.04 and P=0.10). There were more diabetes, hypertension, and hypothyroidism cases in Primary-OA than in PTOA (all P<0.05).Conclusions. PTOA represented 12.4% of all joint diseases in the orthopaedic consult. Past meniscal injuries and hip fractures were the most relevant PTOA associated injuries regarding pain and walking disability. Patients with PTOA have a different profile than patients with primary OA, which would increase their chances of injuries and complications after arthroplasty.
Clinicopathological and prognostic differences of fusion oncogenes in papillary thyroid carcinoma: a meta-analysis of summary and individual patient data
Authors: Vuong Huy Gia , Le Hieu Trong , Le Trang T.B. , Le Thoa , Humaira Sayeda , Hassell Lewis , Kakudo Kennichi 
Published: May 2022

Abstract
IntroductionFusion oncogenes (e.g., NTRK, RET, ALK, BRAF, PPARG) are rare genetic events in papillary thyroid carcinoma (PTC) and little is known about the similarities and differences in clinicopathological manifestations and prognostic outcomes of these genetic alterations. This meta-analysis aimed to investigate the clinicopathological significance and prognoses of different oncogenic fusions in PTC patients.MethodsWe performed a summary-level meta-analysis to compare the fusion-positive with fusion-negative PTCs and individual patient data meta-analysis to analyze the clinicopathological profiles of different oncogenic fusions. The odds ratio and their 95% confidence intervals were calculated using the random-effect model. Chi-square and Fisher’s exact tests were used to compare categorical variables while Wilcoxon rank-sum and analysis of variance (ANOVA) tests were utilized for continuous covariates.ResultsWe included 40 studies for meta-analyses. Compared to fusion-negative PTCs, cases with oncogenic fusions occurred at a younger age and had increased rates of multifocality, vascular invasion, extrathyroidal extension, and nodal/distant metastases. NTRK-, RET-, BRAF-, ALK-, and PPARG-rearranged PTCs had a unique demographic/clinicopathological profile but similar progression-free survival (PFS) and overall survival (OS). NTRK1-positive PTCs demonstrated more aggressive clinical behaviors and shorter PFS in comparison to NTRK3-positive PTCs whereas RET rearrangement variants shared comparable clinicopathological backgrounds.ConclusionThis study provides new insights and facilitates our current understanding of clinicopathological features and survival outcomes of different fusion oncogenes in PTCs. It may help clinicians better counsel the patients and tailor appropriate treatment decisions.
Electrochemiluminescence Sensor based on Electrospun Crosslinked
Carbon Nanofibers for the Detection of Difenidol Hydrochloride
Authors: Cheng Hao , Li Xuenuan , Li Tianhao , Tang Tingfan , Qin Danfeng 
Published: May 2022

Background:
Cross-linked porous carbon nanofibers (CNF) was successfully prepared by electrospinning and high-temperature carbonization. Polyacrylonitrile (PAN) as the carbon source and Genipin as the cross-linking agent were used to prepare Cross-linked porous carbon nanofibers (CNF).

Method and Material:
The field emission Scanning Electron Microscopy (SEM), Transmission Electron Microscope (TEM), Automatic Specific Surface and Porosity Analyzer Brunner Emmet Teller (BET), X-ray Diffraction (XRD), A laser confocal microspectroscope (Raman, XploRA PLUS, Horiba) were used to characterize materials. The CNF suspension was dropped on the surface of the bare glassy carbon electrode by the drip coating method to obtain a CNF modified electrode. Cyclic voltammetry was used to study the electrochemiluminescence behavior of difenidol hydrochloride on CNF modified glassy carbon electrode (Glassy Carbon Electrode, GCE).

Results and Discussion:
Herein, we synthesised a kind of Crosslinked Carbon Nanofibers and designed a novel ECL biosensor, Under the optimal conditions, the concentration of difenidol hydrochloride has a linear relationship with the peak current in the range of 8.0×10-8 to 1.0×10-4mol/L, the correlation coefficient is R2=0.997,	with a low detection limit (1.2×10- 8 mol/L). Difenidol hydrochloride in difenidol hydrochloride tablets was tested, and the recovery rate of sample addition was 83.17%-92.17%, and the RSD was <5.0%. The designed platform exhibited excellent analytical performance towards difenidol hydrochloride determination.
Transcriptome Analysis of Traditional Chinese Medicine ‘Kechuanning
Plaster’ in the Treatment of Asthma
Authors: Li Jingjing , Fan Yanbo , Wang Wei , He Zhiwei , Ding Nian , Lu Lijun , Zhang Jun , Xie Miaomiao 
Published: May 2022

Background:
Asthma is a severe chronic inflammatory airway disease. Kechuanning
plaster has excellent efficacy in the treatment of asthma.

Objective:
The aim of this study was to analyze the molecular mechanisms of Kechuanning plaster
in the treatment of asthma.

Methods:
An asthma model was constructed using Sprague Dawley rats. Differentially expressed
genes (DEGs) were screened in three rat groups: the control (normal rats), model (asthma rats), and
treatment (asthma rats treated with Kechuanning) groups. After enrichment analysis of the DEGs,
the protein-protein interactions (PPIs) of the DEGs were analyzed, and transcription factors and
microRNAs (miRNAs) that regulate DEGs were predicted. Finally, western blotting (WB) and
immunohistochemical (IHC) analysis was performed to validate protein expression.

Results:
A total of 745 DEGs were identified and enriched in 93 Gene Ontology terms and 25
Kyoto Encyclopedia of Genes and Genomes pathways. A PPI network, consisting of 224 protein
nodes and 368 edges, was constructed. The nuclear factor of activated T cells 2 (NFATc2) was
predicted to have binding sites in 61 DEGs. The miRNA-target interaction network included 24
DEGs and 9 miRNAs. WB and IHC analysis demonstrated that the fatty acid-binding protein 5
(FABP5) and the chemokine (C-X-C motif) ligand 3 (CXCL3) had higher expression in the model
group and lower expression in the control and treatment groups.

Conclusion:
We concluded that FABP5, CXCL3, suppressor of cytokine signaling 3 (SOCS3),
E1A binding protein P300 (EP300), NFATc2, microRNA 495 (miR-495), and miR-30 may play
important roles in treating asthma.
Anti-Amyloid-β Immunotherapy: A Leading Novel Avenue for Alzheimer's
Disease
Authors: Babbar Ritchu , Sharma Parth , Sharma Twinkle , Madaan Piyush , Arora Sandeep , Badavath Vishnu Nayak 
Published: May 2022

Abstract:
Alzheimer disease or senile dementia is principally acknowledged by the gradual accumulation of neurotoxic amyloid- β protein in the brain and is considered as the initial event of the phenomenon of this asymptomatic ailment. It prompts the decline in cognitive performance, standard psychiatric functioning, and neuronal transmission across the brain. Significant inferences were withdrawn by utilizing the recently introduced disease-modifying anti- amyloid- β immunotherapy developed after performing the clinical and preclinical controlled trials to cure the neurodegenerative malady. This strategy is worthwhile because of the clinical relevance and specific targeted approach that exhibited the quenched immunotherapeutic effects and encouraged clinical findings. In vitro fabricated, anti- amyloid- β recombinant monoclonal antibodies are passively employed to promote clearance and antagonize the aggregation and synthesis of neurotoxic and degenerative aggregates of amyloid-β. Thus, passive immunotherapy has an adequate impact on treating this disorder, and currently, some other monoclonal pharmacological molecules are under clinical trials to defeat this severe exacerbation with more efficacy and clinical benefits. This review compendiously discusses the anti-amyloid-β immunotherapy which will provide a more proficient framework to be employed as a potential therapeutic approach.
A Non-Invasive IoT-Based Glucose Level Monitoring System
Authors: Jain Shruti , Paul Sudip , Majhi Bikram , Pegu Karobi , Majhi Vinayak 
Published: May 2022

Background:
Diabetes is one of the most common diseases which are major public health problem worldwide. It is also the leading high risk causes of death and disability in the world. To avoid further complications due to diabetes, regular monitoring of blood glucose levels is very important. All the current method used to measure blood glucose is the invasive way, which requires finger piercing, and this invasive method is more painful and more likely to cause infection. However, patients need to be directed towards the development of non-invasive techniques to relieve pain.

Objective:
In this project we use non-invasive techniques that use Near Infrared sensor for glucose level determination from fingertip without requiring needles and test strips.

Methods:
Near Infrared (NIR) optical signal is transmitted through one side of the fingertip and then received from its other side through which blood glucose’s molecular count is predicted by analyzing the variation in the received signal’s intensity after its reflection. And then the signal was filtered and amplified before going into the microcontroller to be displayed on an LCD display. The glucose readings were also sent to a phone via Wi-Fi and displayed through an Android application use of IoT.

Results:
The designed hardware calibrated with regression analysis by a pre calibrated conventional blood sugar machine and the derived equation is being set with respect to voltage vs Blood sugar measurement and set in the microcontroller. Finally the device is being tested with the 5 individual subjects with 10 reading each.

Conclusion:
The device is being designed to measure the Blood Glucose in noninvasive way and it is successfully doing the same beside that the incorporation of IoT in the device give us the freedom of measuring the Blood glucose from the distance and available through the internet.
Evaluating the Correlation between High Titers of Tissue-Transglutaminase Antibody with the Grade of Severity of Villous Atrophy in Syrian Patients with Celiac Disease
Authors: Alhabbal A. , Abou Khamis I. 
Published: May 2022

Background. Diagnosis of celiac disease depends on the patient’s history and serological tests, and is confirmed by biopsies from the duodenum. Biopsies from the small intestine could be dispensable regarding the verification of celiac disease with the presence of high levels of atissue-transglutaminase antibody.Aim. The objective of this investigation is to substantiate the correlation between titers of anti-tissue transglutaminase type IgA (anti-tTG IgA) and the severity of histological alterations in Syrian patients with celiac disease and to determine the diagnostic level of anti-tTG to previse celiac disease in adults and children without the necessity of a biopsy sampling.Materials and methods. The study was conducted as a prospective cohort study with the participation of 100 symptomatic patients between the age group of 6–65 years. All participants underwent upper gastrointestinal endoscopy. Two samples were taken from the duodenum and were evaluated by an expert pathologist according to Marsh grading. Serum anti-tTG IgA levels were measured as well to determine any association between the levels of serum anti-tTG IgA and Marsh grading.Results. The mean age of the patients was (18.55 ± 12.92). Anemia was the most frequent non-gastrointestinal finding as it was found among 35% of the participant, but no remarkable association was found between Marsh grading and hemoglobin levels (r = 0.36, p > 0.05). However, serum tTGA levels were positively correlated with Marsh grading (r = 0.718, p < 0.001). Receiver-operator curve (ROC) analysis cut-off value of serum anti-tTGA for speculating villous atrophy was 270 IU/ml of cut-off value with a sensitivity of 100% and a specificity of 89%.Conclusion. Duodenal biopsies could be foregone during the diagnosis of susceptible patients for celiac diseasewith high anti-tTG IgA.
Clinical Recommendations of the Northwest Society for Enteral and Parenteral Nutrition, Interregional Association for Emergency Surgery, Russian Gastroenterological Association, Union of Rehabilitation Therapists of Russia and Russian Transplantation Society on Diagnosis and Treatment of Short Bowel Syndrome-Associated Intestinal Failure in Adults
Authors: Averyanova Yu. V. , Batyrshin E. M. , Demko A. E. , Ivanova G. E. , Ivashkin V. T. , Kostyuchenko L. N. , Lapitsky A. V. , Leiderman I. N. , Luft V. M. , Maev I. V. , Nikitin I. G. , Novruzbekov M. S. , Poluektova Е. A. , Potapov A. L. , Sytov A. V. , Trukhmanov A. S. 
Published: May 2022

Aim. Current clinical recommendations address the epidemiology, causes, clinical manifestations and pathogenesis of possible immediate and long-term complications, as well as the problematic issues related to treatment and rehabilitation of adult short bowel syndrome patients.Key points. Short bowel syndrome (SBS) is a symptom complex of impaired digestion caused by the reduction of small intestine absorptive surface and manifested by intestinal failure (IF) of various severity (maldigestion and malabsorption) developing into malnutrition and systemic somatogenic disorders. The vital strategic aspects of its treatment are the personalisation of liquid, macro- and micronutrients consumption as well as avoidance of intestinal failure- and parenteral nutrition-associated complications. Various nutritional support regimes and the indications for infusion therapy and maintenance parenteral nutrition are considered in this patient category, also in outpatient settings. To mitigate the dependence on intravenous fluid- and nutrient administration and attain enteral autonomy in SBS-IF patients, the use of recombinant glucagon-like peptide-2 (GLP-2) is justified as exerting a pronounced trophic effect on the epithelial regenerative potential as well as structural and functional adaptation of intestinal mucosa. The SBS-IF patients prescribed with home parenteral nutrition and/or their caregivers should be trained in a special programme that covers the catheter care, preparation of infusion solutions and nutrient mixture container, infusion pump operation as well as the prevention, recognition and management of complications. The main referral indications for small bowel transplantation (SBT) are: fast-progressing cholestatic liver disease-complicated irreversible intestinal failure; thrombosis of two or more central venous conduits used for parenteral nutrition; recurrent catheter-associated bloodstream infection.Conclusion. Current recommendations on diagnosis and treatment as well as the developed criteria of medical aid quality assessment are applicable at different levels of healthcare.
Time With Diabetes Distress and Glycemia-Specific Distress: New Patient-Reported Outcome Measures for the Psychosocial Burden of Diabetes Using Ecological Momentary Assessment in an Observational Study
Authors: Ehrmann Dominic , Schmitt Andreas , Priesterroth Lilli , Kulzer Bernhard , Haak Thomas , Hermanns Norbert 
Published: May 2022

OBJECTIVETo estimate time with diabetes distress using ecological momentary assessment (EMA) in people with type 1 diabetes and analyze its associations with glycemic management based on continuous glucose monitoring (CGM).RESEARCH DESIGN AND METHODSWe used EMA to assess diabetes distress in a sample of recently hospitalized adults with type 1 diabetes once a day for 17 consecutive days in an ambulatory setting. Additionally, participants were asked daily about hypoglycemia distress (&lt;70 mg/dL [3.9 mmol/L]), hyperglycemia distress (&gt;180 mg/dL [10 mmol/L]), and variability distress (glucose fluctuations). Per person, the percentage of days with elevated distress was calculated (time with distress). Multilevel regression was used to analyze daily associations of distress ratings with CGM-derived parameters. EMA-derived associations between diabetes distress and glycemic outcomes were compared with questionnaire-derived associations.RESULTSData of 178 participants were analyzed. Participants spent a mean (SD) of days in a state of diabetes distress, 54.6 ± 26.0% in hyperglycemia distress, 45.2 ± 27.5% in variability distress, and 23.0 ± 19.3% in hypoglycemia distress. In multilevel analyses, higher daily ratings of diabetes distress were significantly associated with hyperglycemia (β = 0.41). Results showed high between-person variability as explanation of variance of the models ranged between 22.2 and 98.8%. EMA-derived diabetes distress showed a significant association with mean glucose (r = 0.25), while questionnaire-based diabetes distress did not (r = 0.10). Prospectively, time with diabetes distress was associated with HbA1c at the 3-month follow-up (r = 0.27), while questionnaire-based distress showed no association (r = 0.11).CONCLUSIONSTime with distress as assessed with EMA showed a comparative advantage over distress as determined by questionnaire-based assessment of diabetes distress regarding associations with glycemic management.
The Implementation Of Geogebra : The Capability Of Students In Mathematical Communication For Primary Student
Authors: Ladysa Dina 
Published: May 2022

The result of international research as Program for International Students Assessment (PISA) in 2006 and The Trends in International Mathematics and Science Study (TIMSS) in 2007 give the same result. Indonesia students in a row get rank 52 from 57 country, and 36 from 48 country that follow the competation. From the result, should be innovation in teaching to enhance the competence of students. One of alternative is using sofware Geogebra, it caused as an hypotesis of me. There are three reasons, that’s why choos MatLab (1) Geogebra is powerful , that can give the best visual that can enhance mathematical communication. (2) Geogebra can related with the real word (3) Geogebra is famous software.
As we know that there are five indicators for mathematical communication. For this article, work sheet that writer explore just the capability conjecture, and generalatation of students. In reality, all of indicator of mathematical communication can be explored using geogebra because the characteristic of geogebra that can be representated all of indicators of mathematical communication.
Post-genomics, Evo-Devo and the recurrence of teleologic thought†
Authors: Layer Paul Gottlob 
Published: May 2022

Abstract
The post-genomic era raises questions about neo-Darwinian genetic determinism. Instead, open aspects of macroevolution become intelligible by Evo-Devo research. At all developmental levels, self-organization acts robustly towards “wholeness”, as exemplified by organoid technologies. In retinal reaggregates histotypical features are reached along different formative routes. Thus, tissue formation is not merely gene-directed, but channeled by unpredictable external conditions. These insights restrict conceptions of onto- and phylogenesis. Neither is characterized by unlimited randomness nor by finite genocentrism. A re-examination of Driesch’s drive to wholeness, i.e., robustness and intentionality, appears timely, while his teleologic postulates remain undecidable by reductionist reasoning.
Comparison between SEPs of CaCO3 and TiO2 in phosphor layer for better color uniformity and stable luminous flux of WLEDs with 7,000 K
Authors: Le Phan Xuan , Trang Tran Thanh , Anh Nguyen Doan Quoc , Lee Hsiao-Yi , Tho Le Van 
Published: May 2022

Abstract
CaCO3 and TiO2 are proposed in this study as particles for scattering enhancement (SEPs) of phosphor-converted white light-emitting diodes (pc-WLEDs). The use of these two SEPs for scattering improvement enables boosting of the color homogeneity of the WLED devices. Each SEP is mixed with YAG:Ce3+ and silicone composition to examine their optical influences and performances on the high-power WLED packages with 7,000 K color temperature (CT). Miescattering theory is applied to calculate and investigate the scattering elements – scattering coefficients, anisotropic scattering, the reduced scattering, and scattering amplitudes – at the wavelengths of 450 nm and 550 nm. The results exhibit that TiO2 and CaCO3 considerably promote higher color uniformity and color-deviated reduction, respectively. The obtained results could be primarily attributed to the significant improvement in the scattering properties of the structure. Additionally, the effects of the presented scattering enhancement on luminous efficiency are displayed. The reduction in lumen output is observed to have a close connection with the concentration and particle size of TiO2 and CaCO3, which means that control must be exercised over these factors when utilizing these SEPs for WLED fabrication.
Call for Papers: The Cooperative, Caring, and Moral Nature of Humans: Honoring David Loye
Authors: Editors IJPS 
Published: May 2022

In honor of the life and work of Dr. David Loye (April 26, 1925 – January 25, 2022), the theme of the second issue of the Interdisciplinary Journal of Partnership Studies in 2022 will be the historical understanding and future possibilities for the more cooperative, caring, and moral nature of humans, including research and practical manifestations of empathy and moral sensitivity. The submission deadline is August 15, 2022.