bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of diurnal and postural intracranial pressure employing telemetric monitoring in idiopathic intracranial hypertension
Authors: Mitchell James L , Buckham Rebecca , Lyons Hannah , Walker Jessica K , Yiangou Andreas , Sassani Matilde , Thaller Mark , Grech Olivia , Alimajstorovic Zerin , Julher Marianne , Tsermoulas Georgios , Brock Kristian , Mollan Susan P , Sinclair Alexandra J 
Published: November 2022

Abstract
Objectives
Intracranial pressure (ICP) has been thought to vary diurnally. This study evaluates diurnal ICP measurements and quantifies changes in ICP occurring with changes in body posture in active idiopathic intracranial hypertension (IIH).

Methods
This prospective observational study utilized telemetric ICP monitoring in people with active IIH. Participants had the Raumedic p-Tel ICP intraparenchymal device (Raumedic, Hembrechts, Germany) surgically inserted. Changes in ICP in the supine position were evaluated. Then, the ICP was measured in the standing, sitting, supine, left lateral decubitus positions and with coughing and bending. Ultimately, changes in ICP over the course of 24 h were recorded. ISRCTN registration number 12678718.

Results
15 women were included, mean (standard deviation) age 29.5 (9.5) years, body mass index 38.1 (6.2) kg/m2, and baseline mean ICP of 21.2 (4.8) mmHg (equivalent to 28.8 (6.5) cmCSF). Mean ICP rose with the duration in the supine position 1.2 (3.3) mmHg over 5-minutes (p = 0.175), 3.5 (2.8) mmHg over 30-minutes (p = 0.0002) and by a further 2.1 (2.2) mmHg over 3 h (p = 0.042). Mean ICP decreased by 51% when moving from the supine position to standing (21.2 (4.8) mmHg to 10.3 (3.7) mmHg respectively, p = 0.0001). Mean ICP increased by 13% moving from supine to the left lateral decubitus position (21.2 (4.8) mmHg to 24.0 (3.8) mmHg, p = 0.028). There was no significant difference in ICP measurements at any point during the daytime, or between 5-minute standing or supine recordings and prolonged ambulatory daytime and end of night supine recordings respectively. ICP, following an initial drop, increased progressively in conjunction with lying supine position from 23:00 h to 07:00 h by 34% (5.2 (1.9) mmHg, p = 0.026).

Conclusion
This analysis demonstrated that ICP does not appear to have a diurnal variation in IIH, but varies by position and duration in the supine position. ICP rose at night whilst the patient was continuously supine. Furthermore, brief standing and supine ICP measures in the day predicted daytime prolonged ambulatory measures and end of night peak ICP respectively. This knowledge gives reassurance that ICP can be accurately measured and compared at any time of day in an ambulant IIH patient. These are useful findings to inform clinical measurements and in the interpretation of ICP analyses in IIH.

Trial registration
ISTCRN (12678718).
Transgenic animal models to explore and modulate the blood brain and blood retinal barriers of the CNS
Authors: Goncalves Andreia , Antonetti David A. 
Published: November 2022

AbstractThe unique environment of the brain and retina is tightly regulated by blood–brain barrier and the blood-retinal barrier, respectively, to ensure proper neuronal function. Endothelial cells within these tissues possess distinct properties that allow for controlled passage of solutes and fluids. Pericytes, glia cells and neurons signal to endothelial cells (ECs) to form and maintain the barriers and control blood flow, helping to create the neurovascular unit. This barrier is lost in a wide range of diseases affecting the central nervous system (CNS) and retina such as brain tumors, stroke, dementia, and in the eye, diabetic retinopathy, retinal vein occlusions and age-related macular degeneration to name prominent examples. Recent studies directly link barrier changes to promotion of disease pathology and degradation of neuronal function. Understanding how these barriers form and how to restore these barriers in disease provides an important point for therapeutic intervention. This review aims to describe the fundamentals of the blood-tissue barriers of the CNS and how the use of transgenic animal models led to our current understanding of the molecular framework of these barriers. The review also highlights examples of targeting barrier properties to protect neuronal function in disease states.
The outcomes of right-sided and left-sided colonic diverticulitis following non-operative management: a systematic review and meta-analysis
Authors: Huang Sih-Shiang , Sung Chih-Wei , Wang Hsiu-Po , Lien Wan-Ching 
Published: November 2022

Abstract
Background
There is no sufficient overview of outcomes in right-sided and left-sided colonic diverticulitis (CD) following non-operative management. This systematic review was conducted to evaluate the recurrence/treatment failure in right-sided and left-sided CD.

Methods
A systematic review was conducted following PRISMA guidelines. MEDLINE, Embase, and Cochrane Library from inception to Dec 2021 were searched. The study characteristics, recurrence/treatment failure, and risk factors for recurrence/treatment failure were extracted. Proportional meta-analyses were performed to calculate the pooled recurrent/treatment failure rate of right-sided and left-sided CD using the random effect model. Logistic regression was applied for the factors associated with the recurrence/treatment failure.

Results
Thirty-eight studies with 10,129 patients were included, and only two studies comprised both sides of CD. None of the studies had a high risk of bias although significant heterogeneity existed. The pooled recurrence rate was 10% (95% CI 8–13%, I2 = 86%, p < 0.01) in right-sided and 20% (95% CI 16–24%, I2 = 92%, p < 0.01) in left-sided CD. For the uncomplicated CD, the pooled recurrence rate was 9% (95% CI 6–13%, I2 = 77%, p < 0.01) in right-sided and 15% (95% CI 8–27%, I2 = 97%, p < 0.01) in the left-sided. Age and gender were not associated with the recurrence of both sides. The treatment failure rate was 5% (95% CI 2–10%, I2 = 84%, p < 0.01) in right-sided and 4% (95% CI 2–7%, I2 = 80%, p < 0.01) in left-sided CD. The risk factors for recurrence and treatment failure were limited.

Conclusion
Non-operative management is effective with low rates of recurrence and treatment failure for both right-sided and left-sided CD although left-sided exhibits a higher recurrence. The recurrence rates did not differ between patients receiving antibiotics or not in uncomplicated CD. Age and sex were not associated with the recurrence although other risk factors were dispersing. Further risk factors for recurrence and treatment failure would be investigated for precise clinical decision-making and individualized strategy.
Small nodules (≤ 6 mm in diameter) of multiple primary lung cancers: prevalence and management
Authors: Cheng Hua , Li Wen-hao , Li Xiao-jian , Zhong Hong-cheng , Wang Xiao-jin , Lin Yu-jing , Liu Xue-guo , Wu Xiang-wen , Cao Qing-dong 
Published: November 2022

Abstract
Background
Synchronous multiple primary lung cancers associated with small non-dominant nodules are commonly encountered. However, the incidence, follow-up, and treatment of small non-dominant tumors have been but little studied. We explored the prevalence and management of small non-dominant tumors and factors associated with interval growth.

Methods
This observational, consecutive, retrospective single-center study enrolled patients diagnosed with synchronous multiple primary lung cancers and small non-dominant tumors (≤ 6 mm in diameter) who underwent resection of the dominant tumor. The incidence, follow-up, and management of small non-dominant tumors and predictors of nodule growth were analyzed.

Results
There were 88 patients (12% of all lung cancer patients) with pathological diagnoses of synchronous multiple primary lung cancers. A total of 131 (18%) patients were clinically diagnosed with at least one small (≤ 6 mm in diameter) multiple primary lung cancer non-dominant tumor. 94 patients with 125 small-nodule non-dominant tumors clinically diagnosed as multiple primary lung cancers were followed-up for at least 6 months. A total of 29 (29/125, 23.2%) evidenced small pulmonary nodules (≤ 6 mm in diameter) that exhibited interval growth on follow-up computed tomography (CT). On multivariate analysis, a part-solid nodule (compared to a pGGN) (OR 1.23; 95% CI 1.08–1.40) or a solid nodule (compared to a pGGN) (OR 3.50; 95% CI 1.94–6.30) predicted small nodule interval growth.

Conclusion
We found a relatively high incidence of multiple primary lung cancers with small non-dominant tumors exhibiting interval growth on follow-up CT, suggesting that resection of non-dominant tumors at the time of dominant tumor resection, especially when the nodules are part-solid or solid, is the optimal treatment.
Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications
Authors: Zhong Xinyang , He Xuefeng , Wang Yaxian , Hu Zijuan , Huang Huixia , Zhao Senlin , Wei Ping , Li Dawei 
Published: November 2022

AbstractColorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death worldwide. Countless CRC patients undergo disease progression. As a hallmark of cancer, Warburg effect promotes cancer metastasis and remodels the tumor microenvironment, including promoting angiogenesis, immune suppression, cancer-associated fibroblasts formation and drug resistance. Targeting Warburg metabolism would be a promising method for the treatment of CRC. In this review, we summarize information about the roles of Warburg effect in tumor microenvironment to elucidate the mechanisms governing Warburg effect in CRC and to identify novel targets for therapy.
How symptoms of prolonged grief disorder, posttraumatic stress disorder, and depression relate to each other for grieving ICU families during the first two years of bereavement
Authors: Wen Fur-Hsing , Prigerson Holly G. , Chou Wen-Chi , Huang Chung-Chi , Hu Tsung-Hui , Chiang Ming Chu , Chuang Li-Pang , Tang Siew Tzuh 
Published: November 2022

Abstract
Background
Bereaved ICU family surrogates are at risk of comorbid prolonged grief disorder (PGD), posttraumatic stress disorder (PTSD), and depression. Knowledge about temporal relationships between PGD, PTSD, and depression is limited by a lack of relevant studies and diverse or inappropriate assessment time frames given the duration criterion for PGD. We aimed to determine the temporal reciprocal relationships between PGD, PTSD, and depressive symptoms among ICU decedents’ family surrogates during their first 2 bereavement years with an assessment time frame reflecting the PGD duration criterion.

Methods
This prospective, longitudinal, observational study examined PGD, PTSD, and depressive symptoms among 303 family surrogates of ICU decedents from two academic hospitals using 11 items of the Prolonged Grief Disorder-13, the Impact of Event Scale—Revised, and the depression subscale of the Hospital Anxiety and Depression Scale, respectively, at 6, 13, 18, and 24 months post-loss. Cross-lagged panel modeling was conducted: autoregressive coefficients indicate variable stability, and cross-lagged coefficients indicate the strength of reciprocal relationships among variables between time points.

Results
Symptoms (autoregressive coefficients) of PGD (0.570–0.673), PTSD (0.375–0.687), and depression (0.591–0.655) were stable over time. Cross-lagged standardized coefficients showed that depressive symptoms measured at 6 months post-loss predicted subsequent symptoms of PGD (0.146) and PTSD (0.208) at 13 months post-loss. PGD symptoms did not predict depressive symptoms. PTSD symptoms predicted subsequent depressive symptoms in the second bereavement year (0.175–0.278). PGD symptoms consistently predicted subsequent PTSD symptoms in the first 2 bereavement years (0.180–0.263), whereas PTSD symptoms predicted subsequent PGD symptoms in the second bereavement year only (0.190–0.214). PGD and PTSD symptoms are bidirectionally related in the second bereavement year.

Conclusions
PGD, PTSD, and depressive symptoms can persist for 2 bereavement years. Higher PGD symptoms at 6 months post-loss contributed to the exacerbation of PTSD symptoms over time, whereas long-lasting PTSD symptoms were associated with prolonged depression and PGD symptoms beyond the first bereavement year. Identification and alleviation of depression and PGD symptoms as early as 6 months post-loss enables bereaved surrogates to grieve effectively and avoid the evolution of those symptoms into long-lasting PGD, PTSD, and depression.
Population-based estimate for the correlation of the Oncotype Dx Breast Recurrence Score® result and Ki-67 IHC MIB-1 pharmDx in HR+, HER2−, node-positive early breast cancer
Authors: Crager Michael , Wijayawardana Sameera R. , Gruver Aaron M. , Blacklock Andrea , Russell Christy , Baehner Frederick L. , Sapunar Francisco 
Published: November 2022

Abstract
Background
The United States Food and Drug Administration recently approved a Ki-67 immunohistochemistry (IHC) assay to identify patients with early breast cancer at high disease recurrence risk. The Oncotype Dx Breast Recurrence Score® assay has been validated in hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2−) invasive breast cancer (IBC) to predict chemotherapy benefit and distant recurrence risk, regardless of nodal status. This study assessed the correlation between Recurrence Score® (RS) results and the Ki-67 IHC MIB-1 pharmDx assay.

Methods
HR+, HER2−, N1 IBC samples with RS results were examined by Ki-67 IHC; 311 specimens were collected, including 275 without regard to RS (“unselected RS”) and 36 more with RS 26–100; 12 were lymph node negative upon pathology report review, and one had no Ki-67 score, leaving 262 unselected RS and 298 total samples. Spearman rank correlation was calculated using the unselected samples and a weighted rank correlation using all samples. A receiver operating characteristic (ROC) curve for predicting high RS (26–100) from Ki-67 was constructed.

Results
The Spearman rank correlation between Ki-67 and RS results was moderately positive (unselected RS samples: 0.396; 95% confidence interval [CI] 0.288–0.493; all samples: 0.394; 95% CI 0.294–0.486). While 71% of samples with RS 26–100 had Ki-67 ≥ 20%, 75% with RS 0–25 had Ki-67 < 20%. ROC area under the curve was 0.792 (95% CI 0.725–0.859).

Conclusions
The moderately positive correlation is consistent with previous analyses suggesting the Oncotype Dx® assay and Ki-67 IHC MIB-1 assay should not be used interchangeably in clinical practice.
Solving an integral equation via generalized controlled fuzzy metrics
Authors: Mani Gunaseelan , Gnanaprakasam Arul Joseph , Dinmohammadi Abdollah , Parvaneh Vahid , Mohammadi Babak 
Published: November 2022

AbstractThe purpose of this manuscript is to obtain some fixed point results in generalized controlled fuzzy metric spaces. Our results generalize and extend many of the previous findings in the same approach. Moreover, two examples to support our theorems are obtained. Finally, to examine and strengthen the theoretical results, the existence and uniqueness of the solution to a nonlinear integral equation is studied as a kind of application.
Climate change scenarios in Zambia: modeling farmers’ adaptation
Authors: Stadtbäumer Charlotte , Ruesink Brigitte , Gronau Steven 
Published: November 2022

Abstract
Background
At the center of the Sustainable Development Goals (SDG) by the United Nations is climate change. Analyzing adaptation processes is fundamental to enhance resilience in the poorest parts of the world. The analysis harmonizes top-down and bottom-up approaches by integrating general circulation models into the method of mathematical optimization. The article designs a quantitative farm planning model for rural Zambia and focuses on optimal allocation of land, labor and cultivation methods. Our research takes advantage of recent survey data of 277 Zambian households from 2018. The model simulates a baseline scenario, 2 climate change scenarios and 7 variations of farmers’ land availability, labor capacity and off-farm work possibility. This results in 21 possible future outcomes and farmer adaptations.

Results
Climate change negatively affects future livelihoods at the study site. A dry climate decreases a farmer’s wealth by around 30% and a wet climate by nearly 20%. However, simulations show households are able to sustain their livelihood through adaptation processes at the farm level. Farmers’ variation in land size for crop cultivation indicates the strongest livelihood impacts in response to climate change. Increasing the land for cultivation is the best response, whereas a reduction of labor supply at the farm leads to households being more vulnerable to a changing climate. Off-farm employments reveal significant potential for climate change adaptation. An increase in work opportunities at a refugee camp nearby has a significant positive effect on rural livelihoods, without reducing the households’ farm production. The refugee camp, however, may imply future land competition.

Conclusions
The study concludes climate change has a serious impact on farm yields and requires land and labor adjustments to prevent losses in wealth. Altering the cropping mix, reallocating planting times or changing farming techniques are meaningful instruments to respond to climate change at the study site. Agricultural intensification can increase the productivity per hectare and the mix of on- and off-farm work indicates income diversification as possible response to climate change. The analysis is specified to a rural farm context in Zambia, but is applicable to similar settings in sub-Saharan Africa and useful for local policy implementations towards climate change adaptation.
DD-KARB: data-driven compliance to quality by rule based benchmarking
Authors: Besharati Mohammad Reza , Izadi Mohammad 
Published: November 2022

AbstractThe problem of compliance checking and assessment is to ensure that the design or implementation of a system meets some desired properties and complies with some rules or regularities. This problem is a key issue in several human and engineering application domains such as organizational management and e-governance, software and IT industries, and software and systems quality engineering. To deal with this problem, some different approaches and methods have been proposed. In addition to the approaches such as formal methods, mathematical proofs, and logical evaluations, benchmarking can be used for compliance assessment. Naturally, a set of benchmarks can shape an applied solution to compliance assessment. In this paper we propose KARB solution system, i.e. keeping away compliance Anomalies through Rule-based Benchmarking. In fact, in our proposed method the rule-based benchmarking means evaluating the conformity of an under-compliance system to a set of rules. In this solution approach, the under-compliance system is specified symbolically (using formal and logical descriptions). Also, the desired rules are specified formally as the semantic logic in the evaluation process. After reviewing the proposed method, a case study was conducted to demonstrate and analyze the KARB solution. The IR-QUMA study (Iranian Survey on Quality in Messenger Apps) was then conducted to evaluate the quality of some messenger applications. According to the evaluation results, the hybrid DD-KARB method (with a combination of semantics-awareness and data-drivenness) is more effective than solo methods and can compute a good estimation for the messenger application user quality scores. Therefore, DD-KARB can be considered as a method for quality benchmarking in this technical context.
Crustal structure beneath earthquake swarm in the Noto peninsula, Japan
Authors: Nakajima Junichi 
Published: November 2022

AbstractWe carried out seismic tomography study to reveal three-dimensional (3D) seismic velocity structures in the Noto peninsula, Japan, where swarm-like seismic activity started in December 2020. The obtained results reveal a highly heterogeneous structure in the crust. The most striking feature is the existence of a low-velocity anomaly in the lower crust beneath the Noto earthquake swarm. Although the data set used in this study cannot resolve the upper mantle structure, previous regional tomographic studies suggest that a low-velocity anomaly exists at depths of 50–150 km around the Noto peninsula that is probably interpreted as a fluid-rich region. We infer that fluids have been supplied from the uppermost mantle to the lower crust over a geological time scale and a large volume of fluids have accumulated below the seismogenic zone beneath the Noto peninsula. A further upward migration of fluids to the upper crust, which may have suddenly started in December 2020, probably triggers numerous earthquakes at depths of 10–15 km. Since major active faults exist at shallower extensions of the hypocenters of the Noto earthquake swarm, we consider that the earthquake swarm occurs along pre-existing and weak fault planes. Dense temporary seismic observations will highlight a smaller-scale (5–10 km) 3D seismic velocity model and finer hypocenter distribution, which provide additional information for better understanding of the generation mechanisms of the Noto earthquake swarm.
Graphical Abstract
Wave propagation of meteotsunamis and generation of free tsunamis in the sloping area of the Japan Trench for the 2022 Hunga–Tonga volcanic eruption
Authors: Tonegawa Takashi , Fukao Yoshio 
Published: November 2022

AbstractMeteotsunamis (forced waves) triggered by atmospheric disturbances of Lamb waves due to the 2022 Hunga–Tonga volcanic eruption have been observed in coastal areas surrounding the Pacific Ocean. However, the spatiotemporal evolution of the wavefield of meteotsunamis and meteotsunami-induced free waves remains elusive. Here, we show the detailed spatial distribution of the propagation velocities and directions of these waves in the bathymetric slope area between the Japan Trench and nearshore, using a dense array of 150 absolute pressure gauges deployed at water depths of 100–8000 m. Records show that free wave components (i.e., tsunamis) were generated when the forced wave was propagating over the slope area. Amplitudes of the generated free waves are large in the southern half of the slope area, where the equi-arrival time contour lines are densely paralleled. Such amplifications occur due to the relationship between the incoming direction of Lamb waves and the gradient of the bathymetric slope. This indicates that, if meteotsunamis excited by Lamb waves due to future volcanic eruptions come from different directions to this region, a different spatial pattern of free wave amplification on a regional scale is obtained in the bathymetric slope areas.
Graphical Abstract
Clinical applications of concentrated growth factors membrane for sealing the socket in alveolar ridge preservation: a randomized controlled trial
Authors: Liu Yumeng , Li Xiaoming , Jiang Changwei , Guo Huiying , Luo Guisheng , Huang Yangyang , Yuan Changyong 
Published: November 2022

AbstractThe purpose of this study was to evaluate the efficacy of concentrated growth factor (CGF) membrane for the sealing of alveolar socket in alveolar ridge preservation (ARP). A total of 22 patients with 24 alveolar sockets were recruited and divided randomly into CGF group and Bio-Gide collagen membrane group. The soft tissue wound healing rate was calculated using intraoral scanner at 3, 7, and 14 days after ARP, and the bone resorption volume at 1, 3, and 5 mm below the alveolar ridge was measured by CBCT at 6 months postoperation. The keratinized gingival width was also measured before and 6 months after ridge preservation. In terms of soft tissue healing rate, the CGF group exhibited significant higher than that of Bio-Gide group at both 7 and 14 days after surgery (P < 0.05). However, there was no significantly different in bone resorption rate and the width of keratinized gingival after 6 months (P > 0.05). Therefore, the use of CGFs membranes for wound closure in ARP is a reliable method, but more clinical data are needed to prove it.