bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fontan Circulation Associated Organ Abnormalities Beyond the Heart, Lungs, Liver, and Gut: A Systematic Review
Authors: Ritmeester Evi , Veger Veerle A. , van der Ven Jelle P. G. , van Tussenbroek Gabrielle M. J. W. , van Capelle Carine I. , Udink ten Cate Floris E. A. , Helbing Willem A. 
Published: March 2022

IntroductionPatients with a Fontan circulation are at risk for sequelae of Fontan physiology during follow-up. Fontan physiology affects all organ systems and an overview of end-organ damage is needed.MethodsWe performed a systematic review of abnormalities in multiple organ systems for patients with a longstanding Fontan circulation. We searched online databases for articles describing abnormalities in multiple organ systems. Cardio-pulmonary abnormalities, protein losing enteropathy, and Fontan associated liver disease have already extensively been described and were excluded from this systematic review.ResultsOur search returned 5,704 unique articles. After screening, we found 111 articles relating to multiple organ systems. We found abnormalities in, among others, the nervous system, pituitary, kidneys, and musculoskeletal system. Pituitary edema—relating to the unique pituitary vasculature- may affect the thyroid axis. Renal dysfunction is common. Creatinine based renal function estimates may be inappropriate due to myopenia. Both lean muscle mass and bone mineral density are decreased. These abnormalities in multiple organ systems may be related to Fontan physiology, cyanosis, iatrogenic factors, or lifestyle.ConclusionsHealth care providers should be vigilant for hypothyroidism, visual or hearing deficits, and sleep disordered breathing in Fontan patients. We recommend including cystatin C for assessment of renal function. This review may aid health care providers and guide future research.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021232461, PROSPERO, identifier: CRD42021232461.
Late Quaternary Drainage Rearrangement Prevents the Vegetation Development in the La Tatacoa Intermontane Basin of the Colombian Andes
Authors: Souza D. H. , Parra M. , del Rio I. , Sawakuchi A. O. , Pupim F. N. , Hernández-González J. S. , Gomez S. 
Published: March 2022

The Tatacoa Desert (TD) is a Cenozoic basin between the Central and Eastern Cordilleras in the southern Colombian Andes. Its sparse vegetation and Badlands morphology resemble a semi-arid environment, despite receiving ∼1,300 mm of mean annual precipitation. Based on optically stimulated luminescence dating in two fluvial terraces and drainage morphometric analysis, we propose that such “aridification” was imposed by a drainage reorganization during the Late Pleistocene. No river coming from the neighboring mountains flows into the TD. This makes the Tatacoa rivers unable to balance the evapotranspiration effect, causing a surficial water deficit. A fluvial terrace (TAT-2) works as a divide between the Tatacoa catchments and the Cabrera River, the latter coming from the Eastern Cordillera and bounding the TD towards the north. Paleocurrent measurements on its sedimentary lithic clasts point to a W-NW-directed flow into the TD. Thus, OSL ages around 74.1 ± 7.0 ka in this terrace suggest the TD was drained by an Eastern Cordillera catchment during the Late Pleistocene. At the western end of the TD, a dissected fluvial terrace (TAT-1) lying 80 m above the Magdalena River ages between 6.3 ± 1.5 and 7.7 ± 1.5 ka, representing the Holocene incision rates of 10.8 ± 0.3 mm/y. Coupled OSL data and river longitudinal profile analysis show a high susceptibility to erosion of the Tatacoa rocks and estimate incision rates ranging from 2–5 mm/y to 10–20 mm/y within the TD. The higher rates are concentrated along knickpoints related to anticlines and thrust faults. Thus, a northward shift of the Cabrera River and a westward migration of the Magdalena Valley have drastically reduced the surficial water availability in the Tatacoa and the development of vegetation, increasing erodibility. Potential climatic and tectonic drivers include 1) terrace accumulation during the wet periods of Marine Isotope Stage 5A and 1; 2) fault-induced incision of the Magdalena River in the NW, which would have favored northward migration of tributaries such as the Cabrera River; and 3) activity on the Baraya thrust fault, which would have prevented rivers from the Eastern Cordillera to enter the desert.
Solution-Processed Titanium Dioxide Ion-Gated Transistors and Their Application for pH Sensing
Authors: Subramanian Arunprabaharan , Azimi Mona , Leong Cheng Yee , Lee Siew Ling , Santato Clara , Cicoira Fabio 
Published: March 2022

Titanium dioxide (TiO2) is an abundant metal oxide, widely used in food industry, cosmetics, medicine, water treatment and electronic devices. TiO2 is of interest for next-generation indium-free thin-film transistors and ion-gated transistors due to its tunable optoelectronic properties, ambient stability, and solution processability. In this work, we fabricated TiO2 films using a wet chemical approach and demonstrated their transistor behavior with room temperature ionic liquids and aqueous electrolytes. In addition, we demonstrated the pH sensing behavior of the TiO2 IGTs with a sensitivity of ∼48 mV/pH. Furthermore, we demonstrated a low temperature (120°C), solution processed TiO2-based IGTs on flexible polyethylene terephthalate (PET) substrates, which were stable under moderate tensile bending.
Ecologic Service, Economic Benefits, and Sustainability of the Man-Made Ecosystem in the Taklamakan Desert
Authors: Congjuan Li , Abulimiti Madinai , Jinglong Fan , Haifeng Wang 
Published: March 2022

The longest artificial highway shelterbelt flowing across the Taklamakan desert was conducted in 2005. To ensure the sustainable development of the highway and shelterbelts, scholars have carried out a large number of studies on the shelterbelt since 1991. This review is based on a 30-year monitoring program from 1991 to 2021. We find that, with the increase of shelterbelt age, some ecological and economic benefits gradually appear, such as saving transportation cost, promoting economic development in Southern Xinjiang, improving the sandy soil and microenvironment, and increasing the biodiversity. In the meanwhile, some adverse phenomena also exist, such as high maintenance costs, decrease in water tables because of irrigation, threats of the protected species, pollution from pumping oil wells, and the potential damage from highway burying as sand dunes move forward. In view of these problems, some suggestions are as follows. First, the science-policy sections of both the UNFCCC and the UNCCD should pay special attention to providing research-based guidance for the international cooperation and coordination. Second, China government should provide the necessary funding to establish the 27th China desert observation and research station to ensure long-term monitoring and slow down the pace of construction on the desert highway to allow time to develop strategies that minimize the impact on wild animals. Third, it is necessary to apply solar photovoltaic power in well irrigation and sand industry development. Fourth, the sand-blocking belt of 10 m width and 10 m away from the outside of the upwind shelterbelt can be laid every five years in view of sand-buried roads. In short, the inter-agency collaboration and coordination are both essential to ensuring the success of sustainable development and management of the Taklamakan Desert man-made ecosystem.
The Ovarian Transcriptome at the Early Stage of Testis Removal-Induced Male-To-Female Sex Change in the Protandrous Black Porgy Acanthopagrus schlegelii
Authors: Tseng Peng-Wei , Wu Guan-Chung , Kuo Wei-Lun , Tseng Yung-Che , Chang Ching-Fong 
Published: March 2022

Unlike gonochoristic fishes, sex is fixed after gonadal differentiation (primary sex determination), and sex can be altered in adults (secondary sex determination) of hermaphroditic fish species. The secondary sex determination of hermaphroditic fish has focused on the differences between testicular tissue and ovarian tissue during the sex change process. However, comprehensive studies analyzing ovarian tissue or testicular tissue independently have not been performed. Hermaphroditic black porgy shows a digonic gonad (ovarian tissue with testicular tissue separated by connective tissue). Protandrous black porgy has stable maleness during the first two reproductive cycles (&lt;2 years old), and approximately 50% enter femaleness (natural sex change) during the third reproductive cycle. Precocious femaleness is rarely observed in the estradiol-17β (E2)-induced female phase (oocytes maintained at the primary oocyte stage), and a reversible female-to-male sex change is found after E2 is withdrawn in &lt;2-year-old fish. However, precocious femaleness (oocytes entering the vitellogenic oocyte stage) is observed in testis-removed fish in &lt;2-year-old fish. We used this characteristic to study secondary sex determination (femaleness) in ovarian tissue via transcriptomic analysis. Cell proliferation analysis showed that BrdU (5-bromo-2′-deoxyuridine)-incorporated germline cells were significantly increased in the testis-removed fish (female) compared to the control (sham) fish (male) during the nonspawning season (2 months after surgery). qPCR analysis showed that there were no differences in pituitary-releasing hormones (lhb and gtha) in pituitary and ovarian steroidogenesis-related factors (star, cyp11a1, hsd3b1, and cyp19a1a) or female-related genes (wnt4a, bmp15, gdf9, figla, and foxl2) in ovarian tissues between intact and testis-removed fish (2 months after surgery). Low expression of pituitary fshb and ovarian cyp17a1 was found after 2 months of surgery. However, we did find small numbers of genes (289 genes) showing sexual fate dimorphic expression in both groups by transcriptomic analysis (1 month after surgery). The expression profiles of these differentially expressed genes were further examined by qPCR. Our present work identified several candidate genes in ovarian tissue that may be involved in the early period of secondary sex determination (femaleness) in black porgy. The data confirmed our previous suggestion that testicular tissue plays an important role in secondary sex determination in protandrous black porgy.
Comprehensive Analysis of YTHDF1 Immune Infiltrates and ceRNA in Human Esophageal Carcinoma
Authors: Liu Xu-Sheng , Kui Xue-Yan , Gao Yan , Chen Xue-Qin , Zeng Jing , Liu Xiao-Yu , Zhang Yu , Zhang Yao-Hua , Pei Zhi-Jun 
Published: March 2022

Background: YTHDF1 is highly expressed in multiple tumors and affects tumor progression. However, there are only a few comprehensive studies on the analysis of YTHDF1 in esophageal cancer.Methods: We analyzed YTHDF1 expression in pan-cancer by comparing both the GEPIA and TCGA cohorts, and further verified the differences in YTHDF1 expression between the ESCA and normal groups by the GEO ESCA cohort and in vitro experiments. The correlation of YTHDF1 expression and the clinical characteristics of ESCA patients was analyzed using the TCGA ESCA clinical data. The GO and KEGG enrichment analyses of the YTHDF1 coexpressed genes were completed by bioinformatics analysis, and the GGI and PPI were constructed for the YTHDF1, respectively. The relationship between YTHDF1 expression and the infiltration of ESCA immune cells was analyzed by using the TIMER database and the TCGA ESCA cohort. The relationships between YTHDF1 expression levels and glycolysis and ferroptosis-related genes were analyzed using the TCGA and GEPIA ESCA cohorts. Finally, the ceRNA network that may be involved in YTHDF1 in ESCA was predicted and constructed through a variety of databases.Results: YTHDF1 was overexpressed in various cancers, and in vitro experiments confirmed that YTHDF1 expression was higher in ESCA samples than in normal samples. The expression of YTHDF1 has some accuracy in predicting the tumor outcome. Expression of YTHDF1 was significantly associated with multiple clinical features in ESCA patients. GO and KEGG enrichment analyses indicated that YTHDF1 coexpressed genes involved multiple biological functions. There is a potential association between YTHDF1 expression and multiple immune cell infiltration, glycolysis, and ferroptosis-related genes in ESCA. YTHDF1 may be involved in multiple ceRNA regulatory networks in ESCA, including PAXIP1-AS1/hsa-miR-376c-3p/YTHDF1 axis, THUMPD3-AS1/hsa-miR-655-3p/YTHDF1 axis, and SNHG20/hsa-miR-655-3p/YTHDF1 axis, respectively.Conclusion: YTHDF1 can serve as a biomarker of ESCA, related to the immune cell infiltration of ESCA, regulation of glycolysis and ferroptosis, and the ceRNA regulatory network.
The Association of Hyperuricemia and Gout With the Risk of Cardiovascular Diseases: A Cohort and Mendelian Randomization Study in UK Biobank
Authors: Zhu Jianwei , Zeng Yu , Zhang Hanyue , Qu Yuanyuan , Ying Zhiye , Sun Yajing , Hu Yao , Chen Wenwen , Yang Huazhen , Yang Jing , Song Huan 
Published: March 2022

BackgroundThe association between hyperuricemia/gout with cardiovascular diseases (CVD) have been investigated. However, whether the magnitude of associations differs between hyperuricemia and gout, and the causality of these associations, remains inconclusive.MethodsBased on UK Biobank, we conducted a cohort analysis including 431,967 participants, who were categorized as gout, hyperuricemia, and normal groups at recruitment, and followed up for CVD until December 2019. The phenotypic association of hyperuricemia/gout with CVD was estimated by Cox regression, adjusting for multiple confounders. Further exploration on the causality of such links was performed using Mendelian Randomization (MR) analysis, where we selected exclusive genetic variants for hyperuricemia and for gout based on summary GWAS data from independent populations.ResultsDuring mean 10.20 years of follow-up, hyperuricemia patients were associated with increased CVD (HR = 1.33, 95% CI: 1.29–1.36), compared to individuals who were free of hyperuricemia/gout. The risk elevation was even higher for gout patients (HR = 1.54, 95% CI: 1.48–1.62). Furthermore, we found significantly positive association between genetic liability for hyperuricemia and CVD in both one-sample (OR = 1.06, 95% CI: 1.02–1.11) and two-sample (OR = 1.09, 95% CI: 1.03–1.16) MR analysis. However, genetic liability for gout was not associated with CVD (OR = 0.89, 95% CI: 0.79–1.01 in one-sample, and OR = 0.92, 95% CI: 0.82–1.21 in two-sample MR analysis).ConclusionIndividuals with hyperuricemia/gout were at increased risk of various types of CVD. As the MR analyses suggest a causal effect of hyperuricemia, but not gout, on CVD, these results indicate the possible effects of other gout-associated factors on the development of CVD, in addition to the uric acid pathway.
Development and Validation of an Artificial Intelligence Preoperative Planning System for Total Hip Arthroplasty
Authors: Chen Xi , Liu Xingyu , Wang Yiou , Ma Ruichen , Zhu Shibai , Li Shanni , Li Songlin , Dong Xiying , Li Hairui , Wang Guangzhi , Wu Yaojiong , Zhang Yiling , Qiu Guixing , Qian Wenwei 
Published: March 2022

BackgroundAccurate preoperative planning is essential for successful total hip arthroplasty (THA). However, the requirements of time, manpower, and complex workflow for accurate planning have limited its application. This study aims to develop a comprehensive artificial intelligent preoperative planning system for THA (AIHIP) and validate its accuracy in clinical performance.MethodsOver 1.2 million CT images from 3,000 patients were included to develop an artificial intelligence preoperative planning system (AIHIP). Deep learning algorithms were developed to facilitate automatic image segmentation, image correction, recognition of preoperative deformities and postoperative simulations. A prospective study including 120 patients was conducted to validate the accuracy, clinical outcome and radiographic outcome.ResultsThe comprehensive workflow was integrated into the AIHIP software. Deep learning algorithms achieved an optimal Dice similarity coefficient (DSC) of 0.973 and loss of 0.012 at an average time of 1.86 ± 0.12 min for each case, compared with 185.40 ± 21.76 min for the manual workflow. In clinical validation, AIHIP was significantly more accurate than X-ray-based planning in predicting the component size with more high offset stems used.ConclusionThe use of AIHIP significantly reduced the time and manpower required to conduct detailed preoperative plans while being more accurate than traditional planning method. It has potential in assisting surgeons, especially beginners facing the fast-growing need for total hip arthroplasty with easy accessibility.
A Fully-Immersive Virtual Reality Setup to Study Gait Modulation
Authors: Palmisano Chiara , Kullmann Peter , Hanafi Ibrahem , Verrecchia Marta , Latoschik Marc Erich , Canessa Andrea , Fischbach Martin , Isaias Ioannis Ugo 
Published: March 2022

Objective: Gait adaptation to environmental challenges is fundamental for independent and safe community ambulation. The possibility of precisely studying gait modulation using standardized protocols of gait analysis closely resembling everyday life scenarios is still an unmet need.Methods: We have developed a fully-immersive virtual reality (VR) environment where subjects have to adjust their walking pattern to avoid collision with a virtual agent (VA) crossing their gait trajectory. We collected kinematic data of 12 healthy young subjects walking in real world (RW) and in the VR environment, both with (VR/A+) and without (VR/A-) the VA perturbation. The VR environment closely resembled the RW scenario of the gait laboratory. To ensure standardization of the obstacle presentation the starting time speed and trajectory of the VA were defined using the kinematics of the participant as detected online during each walking trial.Results: We did not observe kinematic differences between walking in RW and VR/A-, suggesting that our VR environment per se might not induce significant changes in the locomotor pattern. When facing the VA all subjects consistently reduced stride length and velocity while increasing stride duration. Trunk inclination and mediolateral trajectory deviation also facilitated avoidance of the obstacle.Conclusions: This proof-of-concept study shows that our VR/A+ paradigm effectively induced a timely gait modulation in a standardized immersive and realistic scenario. This protocol could be a powerful research tool to study gait modulation and its derangements in relation to aging and clinical conditions.
Determinants of Sugar-Sweetened Beverage Consumption Among the Saudi Adults: Findings From a Nationally Representative Survey
Authors: Al-Hanawi Mohammed Khaled , Ahmed Moin Uddin , Alshareef Noor , Qattan Ameerah Mohammad Nour , Pulok Mohammad Habibullah 
Published: March 2022

BackgroundSaudi Arabia is the fifth largest consumer of calories from sugar-sweetened beverages (SSBs) in the world. However, there is a knowledge gap to understand factors that could potentially impact SSB consumption in Saudi Arabia. This study is aimed to examine the determinants of SSBs in Saudi Arabia.MethodsThe participants of this study were from the Saudi Health Interview Survey (SHIS) of 2013, recruited from all regions of Saudi Arabia. Data of a total of 10,118 survey respondents were utilized in this study who were aged 15 years and older. Our study used two binary outcome variables: weekly SSB consumption (no vs. any amount) and daily SSB consumption (non-daily vs. daily). After adjusting for survey weights, multivariate logistic regression models were applied to assess the association of SSB consumption and study variables.ResultsAbout 71% of the respondents consumed SSB at least one time weekly. The higher likelihood of SSB consumption was reported among men, young age group (25–34 years), people with lower income (&lt;3,000 SR), current smokers, frequent fast-food consumers, and individuals watching television for longer hours (≥4 h). Daily vegetable intake reduced the likelihood of SSB consumption by more than one-third.ConclusionsThree out of four individuals aged 15 years and over in Saudi Arabia consume SSB at least one time weekly. A better understanding of the relationship between SSB consumption and demographic, socioeconomic, and behavioral factors is necessary for the reduction of SSB consumption. The findings of this study have established essential population-based evidence to inform public health efforts to adopt effective strategies to reduce the consumption of SSB in Saudi Arabia. Interventions directed toward education on the adverse health effect associated with SSB intake are needed.
Ramadan Fasting Among Older Children and Adolescents With Type 1 Diabetes Mellitus: A Real-World Study From the UAE
Authors: Muammar Tawfik , Fojas Esphie Grace Fodra , Helal Radwa , Lessan Nader 
Published: March 2022

BackgroundRamadan fasting (RF) is a religious obligation for all healthy adult Muslims. The sick and pre-pubertal children are exempt, but many choose to fast for various reasons. In this “real world” study, glycaemic control has been investigated in the context of RF in children and adolescents with type 1 diabetes mellitus (T1DM) and compared multiple daily injections (MDI) and continuous subcutaneous insulin infusion (CSII) outcomes.MethodsChildren and adolescents with T1DM seen at Imperial College London Diabetes Centre who decided to fast in the ensuing Ramadan were educated with their families about diabetes mellitus management during RF using an adapted CHOICE (Carbohydrate, Insulin, and Collaborative Education) educational programme. Pertinent data including hypoglycaemia episodes and diabetic ketoacidosis (DKA) were obtained through patient/family interviews. Information on weight, glycated hemoglobin (HbA1c), and blood glucose levels from continuous glucose monitoring (CGM)/flash glucose monitoring (FGM) before (1 month prior), during, and after (1 month afterwards) Ramadan were retrieved retrospectively from the electronic database. Data are presented as mean ± SD.ResultsForty-two patients [age 13.5 ± 2.4 years; 27 (64.3%) males; T1DM duration 4.9 ± 3.1 years] were included in the study and were able to fast for 22 ± 9 days during Ramadan. Twenty-three (54.8%) of the patients were on MDI and 19 (45.2%) were on CSII. No statistically significant differences were seen in CGM/FGM generated mean blood glucose level before, during, and after Ramadan [one-way ANOVA (F(2, 80) =1.600, p = 0.21)]. HbA1c and weight after Ramadan did not change significantly compared to baseline (paired t-test; p = 0.02 and p = 0.08, respectively). Between MDI and CSII groups, there was no significant difference in fasting days (p = 0.49), frequency of hypoglycaemia episodes (p = 0.98), DKA frequency (p = 0.37), HbA1c level (p = 0.24), and weight (p = 0.11) after Ramadan.ConclusionData show no significant deterioration in indicators of overall glycaemic control which remained inadequate. RF should be discouraged in children with poorly controlled T1DM.