bluuebunny/crossref_metadata_2025_split huggingface dataset:
Text recall and use of advance organisers in first and second language
Authors: Dhaene Sara , Woumans Evy 
Published: April 2022

AbstractPrevious research identified that studying texts in a second language (L2) as opposed to the first (L1) results in substantially weaker recall. We hypothesized that use of advance organizers (AOs) might attenuate this L2 recall cost by supporting L2 users in the construction of more solid memory representations. One hundred Dutch-English bilinguals studied two texts in either L1 or L2, and with or without the help of a mind map. The previously reported L2 cost was replicated, with lower recall scores in L2 relative to L1. Whereas L1 and L2 students were equally aided by AO use, the initial cost dissipated when comparing L2 test scores in the AO condition with those of L1 in the non-AO condition. We therefore conclude that employing AOs does not entirely diminish L2 disadvantages but brings L2 students up to the initial level of L1 students.
Development of a temperature-based seed germination model for silverleaf nightshade (Solanum elaeagnifolium)
Authors: Kapiluto Omer , Eizenberg Hanan , Lati Ran Nisim 
Published: April 2022

AbstractSilverleaf nightshade (Solanum elaeagnifoliumCav.) has become a highly troublesome weed in irrigated summer crops in Israel. Because herbicide-based options to control this weed are limited, the best way to improve weed control is through a study of its biology, particularly its germination dynamics. The main objective of this study was to determine the impact of temperature on the seed germination dynamics ofS. elaeagnifoliumand to develop a temperature-based (thermal) prediction model for threeS. elaeagnifoliumpopulations growing in different ecosystems in Israel. To this end, a laboratory study was undertaken in which the germination proportion ofS. elaeagnifoliumseeds was monitored under seven temperature regimes: 2/8, 7/13, 12/18, 17/23, 22/28, 27/33, and 32/38 C (night/day). In addition, the impact of alternating temperature regimes between night and day temperatures (of 0, 2, 4, 6, 8, and 10 C), averaged over 20 and 25 C, was determined. It was found that the three populations shared similar germination characteristics and dynamics. An alternation of ≥6 C between night and day temperatures was needed for optimal germination, with no germination taking place under constant temperatures. In all three populations, the minimal requirement for germination was a 12/18 C (night/day) regime, with the final germination proportion lying between 0.25 and 0.36. The highest final germination proportion of ≥0.8 was observed for the 17/23 C regime in all three populations. Modeling the germination rate as a function of temperature allowed us to determine cardinal temperatures for all three populations taken together, with the values beingTb= 10.8 C (base temperature),To= 23.8 C (optimal temperature), andTc= 35.9 C (ceiling temperature). These biological parameters allowed accurate (root mean-square error < 0.06%) prediction ofS. elaeagnifoliumseed germination over the entire temperature range.
Atrial fibrillation designation with micro-Raman spectroscopy and scanning acoustic microscope
Authors: Parlatan Ugur , Parlatan Seyma , Sen Kubra , Kecoglu Ibrahim , Ulukan Mustafa Ozer , Karakaya Atalay , Erkanli Korhan , Turkoglu Halil , Ugurlucan Murat , Unlu Mehmet Burcin , Tanoren Bukem 
Published: April 2022

AbstractAtrial fibrillation (AF) is diagnosed with the electrocardiogram, which is the gold standard in clinics. However, sufficient arrhythmia monitoring takes a long time, and many of the tests are made in only a few seconds, which can lead arrhythmia to be missed. Here, we propose a combined method to detect the effects of AF on atrial tissue. We characterize tissues obtained from patients with or without AF by scanning acoustic microscopy (SAM) and by Raman spectroscopy (RS) to construct a mechano-chemical profile. We classify the Raman spectral measurements of the tissue samples with an unsupervised clustering method, k-means and compare their chemical properties. Besides, we utilize scanning acoustic microscopy to compare and determine differences in acoustic impedance maps of the groups. We compared the clinical outcomes with our findings using a neural network classification for Raman measurements and ANOVA for SAM measurements. Consequently, we show that the stiffness profiles of the tissues, corresponding to the patients with chronic AF, without AF or who experienced postoperative AF, are in agreement with the lipid-collagen profiles obtained by the Raman spectral characterization.
DWI of the Breast – Possibilities and Limitations
Authors: Meyer Hans Jonas , Martin Mireille , Denecke Timm 
Published: April 2022

Background The MRI of the breast is of great importance in the diagnosis of disorders of the breast. This can be stated for the primary diagnosis as well as the follow up. Of special interest is diffusion weighted imaging (DWI), which has an increasingly important role. The present review provides results regarding the diagnostic and prognostic relevance of DWI for disorders of the breast.
Methods Under consideration of the recently published literature, the clinical value of DWI of the breast is discussed. Several diagnostic applications are shown, especially for the primary diagnosis of unclear tumors of the breast, the prediction of the axillary lymph node status and the possibility of a native screening. Moreover, correlations between DWI and histopathology features and treatment prediction with DWI are provided.
Results Many studies have shown the diagnostic value of DWI for the primary diagnosis of intramammary lesions. Benign lesions of the breast have significantly higher apparent diffusion coefficients (ADC values) compared to malignant tumors. This can be clinically used to reduce unnecessary biopsies in clinical routine. However, there are inconclusive results for the prediction of the histological subtype of the breast cancer. DWI can aid in the prediction of treatment to neoadjuvant chemotherapy.
Conclusion DWI is a very promising imaging modality, which should be included in the standard protocol of the MRI of the breast. DWI can provide clinically value in the diagnosis as well as for prognosis in breast cancer.
Key Points:
Citation Format
Regioselective Construction of Coumarin-1,2,4-triazines via a Cs2CO3-Catalyzed [3+3] Cycloaddition Reaction
Authors: Zhang Fa-Guang , Ma Jun-An , Liu Xuan-Yu 
Published: April 2022

AbstractA cesium carbonate (Cs2CO3)-catalyzed [3+3] cycloaddition reaction of coumarin-diazo reagents with glycine imino esters is established to produce tetrahydro-1,2,4-triazines in good yields with excellent regioselectivity. One-pot cycloaddition/oxidation protocol could further provide practical access to a series of new coumarin-decorated 1,2,4-triazines.
Stability and large-time behavior of the inviscid Boussinesq system for the micropolar fluid with damping
Authors: Li Xinliang , Tan Zhong 
Published: April 2022

In this paper, we consider the three-dimensional inviscid Boussinesq system for the micropolar fluid in porous media. We proved the global well-posedness and large time behavior of solutions in the whole space R3. Precisely, when the H3-norm of initial data is small, but the higher-order derivatives can be arbitrarily large, the system is globally well-posed by the pure energy method. Moreover, by a set of mature negative Sobolev and Besov space interpolation methods, the Lp − L2 (1 ≤ p ≤ 2) type of the optimal time decay rates are obtained without any smallness assumption on the Lp norm of the initial data. Our results mathematically explain the stability of the system in an unbounded domain.
Collision excitation of c-C3H−(X1A1) by He
Authors: Mogren Al Mogren Muneerah , Ben Abdallah Driss , Dhaif Allah Al Harbi Sarah , Senent Maria Luisa 
Published: April 2022

Accurate modeling of anionic abundances in the interstellar and circumstellar media requires calculations of collisional data with the most abundant species that are usually He atoms and H2 molecules. In this paper, we focus on smaller cyclic molecular anion, c-C3H−, an astrophysical candidate, following the detection of larger CnH− carbon chains. From a new three-dimensional potential energy surface, the rotational (de-)excitation of the c-C3H−(X1A1) anion by collision with He is investigated. The surface is obtained in the supermolecular approach at the CCSD(T)-F12/aug-cc-pVTZ level of theory. Fully quantum close-coupling calculations of inelastic integral cross sections are performed on a grid of collisional energies large enough to ensure the convergence of the state-to-state rate coefficients for the 34 first rotational levels up to jKa,Kc = 77,0 of c-C3H− and temperatures ranging from 5 to 100 K. For this collisional system, rate coefficients exhibit a strong dominance in favor of 21,2 → l1,1 downward transition. This transition was previously used for the detection of the cyclic parent c-C3H. The c-C3H−–He rate coefficients (∼10−11 cm3 s−1) are of the same order of magnitude as those of the detected anions CnH− (as C2H−, C4H−, and C6H−) in collision with He and one order of magnitude smaller than those with H2. The critical densities of H2 were also estimated, and a discussion on the validity of the local thermodynamic equilibrium conditions is carried out. This work represents the contribution to understanding and modeling abundances and chemistry of hydrocarbon radicals, CnH, in astrophysical media.
A Bayesian MultiLayer Record Linkage Procedure to Analyze Post-Acute Care Recovery of Patients with Traumatic Brain Injury
Authors: Shan Mingyang , Thomas Kali S , Gutman Roee 
Published: April 2022

Summary
Understanding associations between injury severity and postacute care recovery for patients with traumatic brain injury (TBI) is crucial to improving care. Estimating these associations requires information on patients’ injury, demographics, and healthcare utilization, which are dispersed across multiple data sets. Because of privacy regulations, unique identifiers are not available to link records across these data sets. Record linkage methods identify records that represent the same patient across data sets in the absence of unique identifiers. With a large number of records, these methods may result in many false links. Health providers are a natural grouping scheme for patients, because only records that receive care from the same provider can represent the same patient. In some cases, providers are defined within each data set, but they are not uniquely identified across data sets. We propose a Bayesian record linkage procedure that simultaneously links providers and patients. The procedure improves the accuracy of the estimated links compared to current methods. We use this procedure to merge a trauma registry with Medicare claims to estimate the association between TBI patients’ injury severity and postacute care recovery.
Enhancing and stabilization of cord blood regulatory T-cell suppressive function by human mesenchymal stem cell (MSC)-derived exosomes
Authors: Zhang Juan , Ma Xiaoqian , Cao Lu , He Xing , Li Sang , Yang Min , Yang Cejun , Rong Pengfei , Yi Shounan , Ghimire Kedar , Kong Xiangfeng , Wang Wei 
Published: April 2022

Abstract
FOXP3+ regulatory T cells (Tregs) are central to maintaining peripheral tolerance and immune homeostasis. They have the potential to be developed as a cellular therapy to treat various clinical ailments such as autoimmune disorders, inflammatory diseases and to improve transplantation outcomes. However, a major question remains whether Tregs can persist and exert their function effectively in a disease state, where a broad spectrum of inflammatory mediators could inactivate Tregs. In this study, we investigated the potential of mesenchymal stem cell (MSC)-derived exosomes to promote and sustain Tregs function. MSC-conditioned media (MSC-CM) cultured Tregs were more suppressive in both polyclonal and allogeneic responses and were resistant to inflammatory stimulation in vitro compared with the controls. A similar enhancement of Treg function was also observed by culturing Tregs with MSC-derived exosomes alone. The enhanced suppressive activity and stability of Treg cultured in MSC-CM was reduced when exosomes were depleted from MSC-CM. We identified that MSC-derived exosomes could upregulate the expression of LC3(II/I), phosphorylate Jak3 and Stat5 to promote Treg survival, and regulate FOXP3 expression in Tregs. Overall, our study demonstrates that MSC-derived exosomes are capable of enhancing Hucb-Tregs function and stability by activating autophagy and Stat5 signalling pathways. Our findings provide a strong rationale for utilizing MSC-derived exosomes as an effective strategy to enhance Treg function, and improve the overall Tregs-based cell therapy landscape.
Evaluation of an Opioid Overdose Composite Risk Score Cutoff in Active Duty Military Service Members
Authors: Dunham Jacob R , Highland Krista B , Costantino Ryan C , Cliff Rutter W , Rittel Alexander G , Kazanis William H , Palmrose Gregory H 
Published: April 2022

Abstract

Objective
To evaluate the current cutoff score and a recalibrated adaptation of the Veterans Health Administration (VHA) Risk Index for Serious Prescription Opioid-Induced Respiratory Depression or Overdose (RIOSORD) in active duty service members.

Design
Retrospective case-control.

Setting
Military Health System.

Subjects
Active duty service members dispensed ≥ 1 opioid prescription between January 1, 2018, and December 31, 2019.

Methods
Service members with a documented opioid overdose were matched 1:10 to controls. An active duty-specific (AD) RIOSORD was constructed using the VHA RIOSORD components. Analyses examined the risk stratification and predictive characteristics of two RIOSORD versions (VHA and AD).

Results
Cases (n = 95) were matched with 950 controls. Only 6 of the original 17 elements were retained in the AD RIOSORD. Long-acting or extended-release opioid prescriptions, antidepressant prescriptions, hospitalization, and emergency department visits were associated with overdose events. The VHA RIOSORD had fair performance (C-statistic 0.77, 95% CI 0.75, 0.79), while the AD RIOSORD did not demonstrate statistically significant performance improvement (C-statistic 0.78, 95% CI, 0.77, 0.80). The DoD selected cut point (VHA RIOSORD &gt; 32) only identified 22 of 95 ORD outcomes (Sensitivity 0.23), while an AD-specific cut point (AD RIOSORD &gt; 16) correctly identified 53 of 95 adverse events (Sensitivity 0.56).

Conclusions
Results highlight the need to continually recalibrate predictive models and to consider multiple measures of performance. Although both models had similar overall performance with respect to the C-statistic, an AD-specific index threshold improves sensitivity. The calibrated AD RIOSORD does not represent an end-state, but a bridge to a future model developed on a wider range of patient variables, taking into consideration features that capture both care received, and care that was not received.
Major determinants of prolonged remission in systemic lupus erythematosus: retrospective study over a 41+ year period
Authors: Durao-Carvalho Goncalo , Fernández-González Raquel , Goulden Bethan , Farinha Filipa , Isenberg David 
Published: April 2022

Abstract

Objectives
To investigate predictors of sustained complete remission (CR) for 3 and 5 years, minimum.

Methods
Retrospective observational study from January 1978 to December 2019, including systemic lupus erythmatosus (SLE) patients who attended the Lupus Clinic in a tertiary hospital, for at least 3 years. We used the BILAG score and serological profile to classify patients into CR, serologically active clinically quiescent (SACQ) and serological remission (SR). Multivariable Cox regression analysis was performed to investigate predictors of CR and Kaplan–Meier curves were obtained.

Results
We included 564 patients; 15% achieved CR, 7% SACQ and 15% SR. Some 63% attained no remission. In the CR group, 73% sustained the remission for 5 years or more. Patients who did not reach any kind of sustained remission died significantly earlier (P &lt; 0.001). Cumulative survival figures at 5, 10, 20 and 30 years were 100, 100, 94 and 90%, respectively, for CR patients and 96, 93, 77 and 58%, respectively, for patients in the no-remission group. Significant predictors of CR were White ethnicity [adjusted hazard ratio (HR) 2.16 (95% CI 1.30–3.59); P = 0.003]; older age at diagnosis (&gt;32 years) [HR 1.92 (1.24–2.97); P = 0.003]; absence of renal involvement [HR 2.55 (1.39–4.67); P = 0.002]; and of antiphospholipid syndrome (APS) [HR 4.92 (1.55–15.59); P = 0.007].

Conclusion
Patients not achieving any kind of sustained remission have a higher risk of early mortality. White ethnicity, older age at diagnosis, absence of renal involvement and of APS were significantly associated with CR. Predictors for sustained CR do not change whether a 3-year or 5-year period is applied.
Swiss Foundation Law—Tightrope act between freedom and regulation
Authors: Jakob Dominique , Brugger Lukas 
Published: April 2022

Abstract
While a recently adopted reform of foundation law will bring facilitations for some types of Swiss foundations, other developments draw a less optimistic picture, especially for Swiss family foundations. This article gives an overview of the most recent developments and trends in Swiss foundation law and sheds light on the question, what role the newly presented draft bill for a Swiss trust law can play in this context.
Long-Term Outcomes of Big Bubble Deep Anterior Lamellar Keratoplasty in Mucopolysaccharidoses: A Retrospective Case Series and Review of the Literature
Authors: Hallal Ramon , Armstrong Grayson W. , Pineda Roberto 
Published: April 2022

Purpose:
The purpose of this study was to report the long-term surgical and visual outcomes of patients with mucopolysaccharidoses (MPS) after big bubble deep anterior lamellar keratoplasty (BB-DALK).

Methods:
This was a retrospective case series of patients with MPS who underwent BB-DALK at a single academic institution. All patients had corneal clouding secondary to MPS limiting visual acuity for which keratoplasty was indicated. Each patient was evaluated and underwent surgery by a single surgeon. Reported data included age at keratoplasty, sex, MPS type, best spectacle-corrected visual acuity, change in pachymetry, ocular comorbidities, surgical complications, and MPS-related medication use.

Results:
Outcomes of 12 eyes from 7 patients with MPS type I (Hurler, Scheie, and Hurler–Scheie) are reported using the newest nomenclature. The mean follow-up was 5.58 years (range: 1–10 years). All cases underwent BB-DALK with a type 1 big bubble during the surgery. Two cases (16.6%) required rebubbling because of partial Descemet membrane detachment. One case was complicated by a suture abscess and required a penetrating keratoplasty. No episodes of rejection occurred. Statistically significant improvement in the best spectacle-corrected visual acuity (from a mean 0.85–0.33 logarithm of the minimum angle of resolution, P = logarithm of the minimum angle of resolution 0.0054) and pachymetry (mean reduction of −145.4 μm, P = 0.0018) was observed.

Conclusions:
BB-DALK seems to be an acceptable long-term surgical option in patients with MPS. Our findings suggest that this technique is reproducible and can achieve clear corneal grafts with good visual results on a long-term follow-up.
On the hip abduction moment required to balance on one leg: an experimental study
Authors: Shahshahani Payam Mirshams , Masteling Mariana , Ashton-Miller James A. 
Published: April 2022

1.AbstractAlthough the time a patient can stand on one leg is a common clinical test of balance in those prone to fall, a surprising knowledge gap is how much hip abduction muscle strength is required. This is important because hip abduction strength has been shown to be important for compensating for impairments in diabetic neuropathy, for example. As a start we tested the hypothesis that maximum hip abduction muscle endurance time at 50% effort would be longer than the time that 18 young and 17 older healthy adults can stand on one leg. First, maximum hip abduction endurance time at 50% effort as well as maximum abduction strength were measured in the gravity-free plane. Then subjects were asked to balance on their left foot for as long as they could while body segment kinematics and ground reaction data were measured. The results showed that the mean intensity of the hip abduction moment required to stand on one leg exceeded 50% of the maximum hip abduction strength for all four groups (young women and men 53% and 55%, and older women and men 94% and 72% respectively). However, unipedal stance times were not limited by hip abduction 50% effort endurance time (p = 0.9). Therefore a significant portion of the hip abduction moment required to stand on one leg must be carried by passive tissues. The underlying mechanism remains to be explained.
Online randomised trials with children: A scoping review protocol
Authors: Lepage Simone , Conway Aislinn , Goodson Noah , Wicks Paul , Devane Declan 
Published: April 2022

AbstractIntroductionThis scoping review will determine how online, randomised trials with children are conducted. The objectives of the review are: (a) to determine what methods and tools have been used to create and conduct online trials with children and (b) to identify the gaps in the knowledge in this field.Over the last decade, randomised trials employing online methods have gained momentum. Decentralised methods lend themselves to certain types of trials and can offer advantages over traditional trial methods, potentially increasing participant reach and diversity and decreasing research waste. However, decentralised trials that have all aspects of the trial exclusively online are not yet common, and those involving children even less so. This scoping review will describe and evaluate the methods used in these trials to understand how they may be effectively employed.MethodsMethods are informed by guidance from the Joanna Briggs Institute and the Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for scoping reviews. The search strategy was developed in consultation with an information specialist for the following databases: MEDLINE, CENTRAL, CINAHL, and Embase. Grey literature searches will be completed with the consultation of experts in decentralised trials and digital health using internet searches and suitable trial registries. Once identified, included full-text studies’ references will be manually searched for any trials that may have been missed. We will include randomised and quasi-randomised trials conducted exclusively online with participants under the age of 18 published in English. We will not limit by country of conduct or date of publication. Data will be collected using a data charting tool and presented in text, graphical, and tabular formats.Ethics and DisseminationEthical approval is not needed since all data sources used are publicly available. The review will be available as a preprint before publication in an open-access, peer-reviewed journal.