bluuebunny/crossref_metadata_2025_split huggingface dataset:
Homoeopathic Treatment of Fibrocystic Breast Diseases: A Case Series
Authors: Shukla Purnima , Misra Purak , Jain Risabh Kumar , Misra Rajiv Kumar 
Published: May 2022

AbstractFibrocystic changes are the most frequently occurring benign conditions of breast disease. Women of 20 to 50 years of age who frequently encounter various forms of stressors have the highest incidence of fibrocystic breast disease (FBD). In cases, where any palpable mass is detected after clinical examination, mammograms and ultrasonography (USG) are the most common investigative tools for the next level of assessment. Five patients with FBD were treated with homoeopathic medicines in our hospital within a period of 3 years under the project: ‘Homoeopathic management of benign neoplastic lesions of breast: an evidence-based study’. The diagnosis was based on clinical examination and USG. We followed standard homoeopathic guidelines for the final selection of medicines. Individualised homoeopathic medicines were used to treat these cases. The clinical assessment was done every month and objective assessment was done after serial USG reports at every 6-month interval. All the patients had notable improvements during treatment as inferred clinically as well as from the USG reports. Few associated symptoms improved too. Assessment of the causal attribution of the outcomes of the treated cases to the homoeopathic intervention was done using Modified Naranjo Criteria. ‘Definite’ association was found in four out of five cases and one case showed a ‘probable’ association. Therefore, we may conclude that homoeopathic treatment can be useful in treating FBD. Good-quality clinical trials are needed before making any firm recommendation.
Exploring the Molecular Mechanism of Homoeopathic Medicines against Cancer: A Pragmatic Approach with Narrative Review of Cell Line Studies
Authors: Dixit Ashish Kumar , Mukherjee Sukhes , Javed Danish , Giri Nibha 
Published: May 2022

Abstract
Background Cancer (CA) is the second leading cause of death, accounting for one out of every six deaths worldwide. Chemotherapy and radiation treatments have unwanted effects and due to financial constraints are not available to a large portion of the population. Many CA patients turn to homoeopathy to improve their quality of life and to relieve pain caused by illness/conventional treatments.
Objective The review aims to appraise and summarise the findings of various in vitro CA cell line studies on homoeopathic medicines (HMs) and the detailed molecular mechanism behind the anti-CA effects of HMs.
Methods A systematic search was conducted on the major electronic biomedical database PubMed/MEDLINE for articles on homoeopathy and the CA cell line published between 25 June 2011 and 24 June 2021.
Result The searches identified 18 relevant articles. HMs showed cytotoxicity, increase in reactive oxygen species and decrease in mitochondrial membrane potential against CA cells while preserving normal cells. It interacts with deoxyribonucleic acid and up- and down-regulation of pro- and anti-apoptotic signalling proteins (p53, caspase-3 and Bax:B-cell lymphoma 2 [Bcl-2]), which all are involved in apoptosis. Increasing the treatment time of CA cells resulted in a higher percentage of cells in the G0/G1 phase (cell cycle arrest) and also showed inhibition of cell migration. HMs also had a complex effect on gene expression profiles.
Conclusion This review highlights preliminary laboratory evidence that HMs have therapeutic potential for combating the menace of carcinogenesis. More data are needed to show anti-tumour potential in the current setting and therapeutic value in battling CA.
Outcome of Homoeopathic Intervention in Psychiatric Inpatients Treated in Rural Homoeopathic Hospital, Palghar, Maharashtra, India, 2014–2018: A Retrospective Analysis
Authors: Nikumbh Sunita , Kukde Abhishek , Patel Manoj , Parekh Bhavik , Nigwekar Anoop , Mittal Renu , Dhawale Kumar 
Published: May 2022

Abstract
Background Rural homoeopathic hospital has been serving the community in and around Palghar for the past 20 years. Through a Central Government Scheme of Centre of Excellence, it received funds for setting up an inpatient psychiatric unit in 2012 whereby it could serve the wider community by admitting the patients with mental illness in a secure ward. This is the second of two papers on the experience of homoeopathic treatment of psychiatric inpatients and details of the outcome of homoeopathic treatment to patients admitted between 2014 and 2018.
Objective Efforts have been made to explore the outcomes of homoeopathic intervention, singly or as adjuvant treatment, for a variety of clinical conditions and to determine the commonly indicated remedies that were found useful.
Methodology A standard operating procedure enabled symptom analysis and evaluation; it also enabled to erect the homoeopathic totality and institute treatment along with conducting the follow-up. Retrospective analysis using Outcome Related to Impact on Daily Living scale helped to establish the results of homoeopathic intervention.
Results An excellent response to homoeopathic intervention was obtained for several clinical conditions like alcohol withdrawal (76.3%), conversion disorder (82.17%), suicide attempt (85.13%), anxiety disorders (84.19%), depressive disorders (75%) and somatoform (85.17%). The rate of improvement in schizophrenia (60%) and epilepsy (22.6%) was lower. The commonly indicated homoeopathic remedies for each clinical condition were identified. This information would help practitioners to acquire knowledge of a pool of remedies from which they could readily determine the similimum.
Conclusion Homoeopathic treatment, either alone or as an adjuvant, is useful in the management of psychiatric inpatients for several clinical conditions. Remedies found useful in different clinical conditions need to be studied in greater depth to identify their leading indications.
COVID-19-Associated Portal Vein Thrombosis Post-Cholecystitis
Authors: Guevara Sara , Miyara Santiago J. , Aronsohn Judith , Homsi Joseph T. , McCann-Molmenti Alexia , Mumford James M. , Keber Barbara , Shore-Lesserson Linda , Morales Luis , Metz Christine N. , Cho Young Min , Molmenti Christine L. Sardo , Loto Rodrigo , Pesce Martin M. , Zafeiropoulos Stefanos , Giannis Dimitrios , Pipolo Derek O. , Jacque Francky , Montorfano Lisandro , Shinozaki Koichiro , Shoaib Muhammad , Choudhary Rishabh C. , Nishikimi Mitsuaki , Takegawa Ryosuke , Endo Yusuke , Hayashida Kei , Fontan Fermin M. , Becker Lance B. , Molmenti Ernesto P. 
Published: May 2022

AbstractThis case study describes a 45-year-old Caucasian male with a past medical history of obesity, hypertension, and non-insulin-dependent diabetes mellitus, who in the setting of coronavirus disease 2019 (COVID-19) pneumonia, developed portal vein thrombosis (PVT) presenting as an acute abdomen after hospital discharge from a cholecystitis episode. PVT is a very infrequent thromboembolic condition, classically occurring in patients with systemic conditions such as cirrhosis, malignancy, pancreatitis, diverticulitis, autoimmunity, and thrombophilia. PVT can cause serious complications, such as intestinal infarction, or even death, if not promptly treated. Due to the limited number of reports in the literature describing PVT in the COVID-19 setting, its prevalence, natural history, mechanism, and precise clinical features remain unknown. Therefore, clinical suspicion should be high for PVT, in any COVID-19 patient who presents with abdominal pain or associated signs and symptoms. To the best of our knowledge, this is the first report of COVID-19-associated PVT causing extensive thrombosis in the portal vein and its right branch, occurring in the setting of early-stage cirrhosis after a preceding episode of cholecystitis.
Preparation and Standardisation of Mother Tincture from Strychnos potatorum: A New Drug Source in Homoeopathy
Authors: Chattopadhyay Rajat , Gupta Sharmistha , Chakraborty Suman , Saha Sangita , Bhar Kaushik 
Published: May 2022

AbstractStrychnos potatorum L.f. is a deciduous tree of 12 metre height, belongs to Loganiaceae family under genus Strychnos and is commonly distributed throughout India. Its flowering time is from February to May and fruiting time from October to March. This plant contains diaboline as active compound and besides it, terpenoid, cardiac glycoside and phenolic compounds as other phytochemical constituents. Recent study has revealed that the plant's seed has antidiabetic, nephroprotective, hepatoprotective, antipyretic, antineoplastic, antimicrobial and contraceptive properties. Hence different systems of medicine like Ayurveda, Unani and Siddha have included this plant in their pharmacopoeial preparation and use it according to their own principles. Ayurvedic system uses the seed against skin disease, gonorrhoea, fever and inflammation of the eyes. Unani system uses it for treatment of urinary complaints whereas Siddha system uses it for treatment of chronic obstructive pulmonary disease. Genus Strychnos is a well-known genus to homoeopathy system. Drugs like Ignatia and Nux vomica belong to this genus, but no data till today regarding the above-stated plant are available in the homoeopathic pharmacopoeia of India. So, the objective of this physiochemical study is to search the scope of inclusion of this plant as new medicinal source in homoeopathic system of medicine for the purpose of drug proving. Keeping this objective in our mind, chemical analysis of the ethanolic extract of the seed was done by thin layer chromatography and ultraviolet-visible spectrophotometry, which was followed by preparation and standardisation of mother tincture.
Autism Spectrum Disorder Managed with Individualised Homoeopathic Medicine—Analysis of 20 Cases
Authors: Gilla Deepthi , Sreeja K.R. , Resmy R. 
Published: May 2022

Abstract
Background Autism spectrum disorder (ASD) is an umbrella term used to describe a constellation of early-appearing social communication deficits and repetitive sensory-motor behaviours. There is a dramatic increase in prevalence of ASD in the past few decades. Autism is a potentially lifelong impairing disorder usually managed with complementary therapies, symptomatic behavioural, sensory integration therapies and medical treatments. As there are currently no specific medicines that can address core disabilities of ASD, there is a desperate need to explore new interventions in ASD.
Objectives The aim of this study is to assess the effectiveness of homoeopathic medicines in the usual care setting, i.e. regular OPD, for the management of ASD using Autism Treatment Evaluation Checklist (ATEC).
Materials and Methods The present study is a case series analysis of 20 cases diagnosed as ASD and evaluated with ATEC in the outpatient unit of Department of Psychiatry, National Homoeopathy Research Institute in Mental Health. Individualised homoeopathic medicines were prescribed based on classical homoeopathic principles. Wilcoxon signed-rank test was used to compare ATEC scores at baseline to end of 12 months.
Results The median baseline ATEC score of 110.0 (116.0–94.5) reduced to 33.5 (61.75–25.0) at p < 0.001, with an effect size of 0.88. There was statistically significant difference in all domains of speech language communication, sociability, sensory/cognitive awareness and health/physical/behaviour when compared from baseline to end of 12 months. Calcarea carbonica, Calcarea phosphorica, Carcinosinum, Mercurius solubilis, Natrum muriaticum, Silicea, Theridion, Tuberculinum, Zincum metallicum etc. were commonly indicated homoeopathic medicines.
Conclusion Individualised Homoeopathic medicines are effective in the management of ASD. Well planned, methodically rigorous research is warranted to corroborate the evidence.
The UV prolate spectrum matches the zeros of zeta
Authors: Connes Alain , Moscovici Henri 
Published: May 2022

Significance
We show that the eigenvalues of the self-adjoint extension (introduced by A.C. in 1998) of the prolate spheroidal operator reproduce the UV behavior of the squares of zeros of the Riemann zeta function, and we construct an isospectral family of Dirac operators whose spectra have the same UV behavior as those zeros.
Experimental observations of marginal criticality in granular materials
Authors: Wang Yinqiao , Shang Jin , Jin Yuliang , Zhang Jie 
Published: May 2022

Significance
Amorphous materials, such as grains, foams, colloids, and glasses, are ubiquitous in nature and our daily life. They can undergo glass transitions or jamming transitions to obtain rigidity either by fast quench or compression, but show subtle changes in the structures compared to the liquid states or liquid-like states. Recent progress on the first-principle replica theory unifies the glass transition and the jamming transition and points out the marginal phase with fractal free-energy landscape within the stable glass phase. Independently, marginal stability analysis predicts the relations between the exponents of the marginal phase. Here, we perform experiments with photoelastic disks and provide direct evidence of these theories in real-world amorphous materials.
Translating the sacred
Authors: Al-Sharafi Abdul Gabbar , Ahmad Rizwan 
Published: May 2022

Abstract
One of the contentious issues in religious translation since the legendary St. Jerome is the degree of the
translator’s agency. The point of contention has been whether the translator can exercise agency and freedom in translating sacred
texts or they should strictly adhere to the form and attend to what St. Jerome called the “mysterious syntax” of the sacred text.
Using a stylistic approach (Abdul-Raof 2001 and 2006; Abdel Haleem 1992), we address the issue of the translator’s agency
in religious translation by examining the translations of a unique rhetorical feature, namely the verb-noun alternation, by seven
key translators in Verses 59, 64, 69 and 72 of Chapter 56, Al-Wāqi‘ah. Despite the general assumption that
religious translation is highly constrained and that the translators of this type of text have little freedom, the findings of
this paper show that religious translators, in fact, do exercise agency in their translation, whether in the form of adapting the
source text to the target text readers or in the form of reproducing the grammatical patterning of the source text for cultural or
ideological reasons.
Polyphonic workflows
Authors: Garcia-Masson Grecia , Espinoza-Alarcón Francisco , Villanueva-Jordán Iván 
Published: May 2022

Abstract
The dubbing process is usually depicted as a linear model in which its participants occupy fixed roles determined by their specializations. However, Torre A, a Peruvian dubbing firm, applies alternative procedures in an emerging context of the dubbing industry. This first case study of dubbing in Peru seeks to examine the dubbing process employed by the agency Torre A based on two projects taking place during its emerging stage as a company. Participants from both projects were interviewed to reconstruct each project workflow. The workflows were then analyzed to contrast the monological, linear theoretical model found in the literature with the dialogical model arising from the participants’ voices. The results show the looping nature of the dubbing process, which is comprised of tasks performed simultaneously or repeatedly by versatile agents whose roles depend on available human and temporal resources as well as intrinsic motivation. This multiplicity of roles also influences the quality criteria used by the agents, who formulate criteria based on their professional perspectives, experiences, and general knowledge of the dubbing process. Thus, a variety of dubbing project circumstances determine how dubbing takes place. This represents a departure from the traditional, or standardized, model of dubbing.
Metaphorical experience
Authors: Gibbs Jr. Raymond W. 
Published: May 2022

AbstractThis article examines whether metaphorical experiences are better characterized in terms of contiguity or cross-domain mappings. My claim is that many facets of concrete experience are infused with metaphoricity as part of our ordinary understanding of these events. Many source domains in conceptual metaphors may also be interpreted via different metaphorical ideas. If both source and target domains in metaphorical concepts may be characterized in metaphorical terms, then the relationship between them may be related via contiguity or metonymy rather than cross-domain mappings. For this reason, metaphorical concepts and language may originate in the contiguous, and at times almost isomorphic, relationships between concrete actions and larger metaphorical ideas.
The size of shame and pride
Authors: Soriano Cristina , Valenzuela Javier 
Published: May 2022

Abstract
We investigate the figurative size (big or small) that more naturally fits the conceptual representation of the moral emotion concepts pride and shame. We hypothesize the pairings pride-big and shame-small to be more natural than their counterparts, because of the emotions’ expressive profile: pride’s expanded body posture makes us look big, while shame’s shrunk body posture makes us look small. These effects are part of the folk model of pride and shame observed in language and the mapping can be best described as metonymic. An Implicit Association Test is used to investigate the existence of these conceptual pairings in Spanish. Faster reaction times and fewer errors were observed for metonymy-congruent compared to incongruent pairs. These results provide the first empirical evidence of a cognitive association coherent with our hypothesized metonymic link and constitute an empirical psycholinguistic contribution to the study of conceptual metonymy.
Rosie the Riveter of the COVID time
Authors: Brdar Mario , Brdar-Szabó Rita , Gradečak Tanja 
Published: May 2022

Abstract
Cyclic repetition can be observed in the use of figurative elements in the conceptualization of the coronavirus
crisis, involving visual intertextuality or intervisuality. An example is provided by Rosie the Riveter, an
iconic image from WW2, which has become extremely popular in recent times. The image in question has undergone a number of changes
over time. Initially it was used as a personification thereby becoming a feminist symbol (essentially a stereotype). Then, it
continued as a paragon. More recently it has acquired new meanings and functions by dispensing with almost all paragon and
stereotype elements. These changes have been driven or supported by metonymies. Some of these metonymies have had an intrinsic or
constitutive role, while other have had an extrinsic or recontextualizing role. The effects of the latter can be appreciated in
the light of exemplification theory, which we take here to be a special form of discourse framing that heavily relies on metonymy.
The metonymic figurativity analyzed in this article is not purely referential. There is added attitudinal value that primarily
arises from establishing social rapport, creating empathy, and mobilizing citizens for action, while criticizing certain
behaviors.
Study of the rare decay

at the BESIII *
Authors: Zhang Feng , Wang Jian-Xiong 
Published: May 2022

Abstract
The two-photon radiative decay process

was studied, and the main contribution processes,

and

, were calculated. With the specific conditions at the BESIII, this rare decay process and the main background process

were investigated. The results show that the ratio of signal to background can reach 1.24 with optimized selection criteria at the BESIII. In addition, distributions of the signal and background are presented. All the results show that the signal is large enough to be experimentally measured.
Generalized electrical substitution methods and detectors for absolute optical power measurements
Authors: Woods S I , Neira J E , Proctor J E , Rice J P , Tomlin N A , White M G , Stephens M S , Lehman J H 
Published: May 2022

Abstract
We have developed generalized methods for electrical substitution optical measurements, as well as cryogenic detectors which can be used to implement them. The new methods detailed here enable measurement of arbitrary periodic waveforms by an electrical substitution radiometer (ESR), which means that spectral and dynamic optical power can be absolutely calibrated directly by a primary standard detector. Cryogenic ESRs are not often used directly by researchers for optical calibrations due to their slow response times and cumbersome operation. We describe two types of ESRs with fast response times, including newly developed cryogenic bolometers with carbon nanotube absorbers, which are manufacturable by standard microfabrication techniques. These detectors have response times near 10 ms, spectral coverage from the ultraviolet to far-infrared, and are ideal for use with generalized electrical substitution. In our first tests of the generalized electrical substitution method with FTS, we have achieved uncertainty in detector response of 0.13% (k = 1) and total measurement uncertainty of 1.1% (k = 1) in the mid-infrared for spectral detector responsivity calibrations. The generalized method and fast detectors greatly expand the range of optical power calibrations which can be made using a wideband primary standard detector, which can shorten calibration chains and improve uncertainties.
A transcriptome sequencing study on the effect of macro-pores in hydrogel scaffolds on global gene expression of laden human cartilage chondrocytes
Authors: Xue Junqiang , Yang Wei , Wang Xinping , Wang Peiyan , Meng Xinyue , Yu Tengbo , Fan Changjiang 
Published: May 2022

Abstract
The macro-porous hydrogel scaffolds can not only enhance the proliferation of laden chondrocytes but also favor the deposition of hyaline cartilaginous extracellular matrix, however, the underlying molecular mechanism is still unclear. Herein, the global gene expression of human cartilage chondrocytes (HCCs) encapsulated in traditional hydrogel (Gel) constructs and micro-cavitary gel (MCG) constructs are investigated by using high-throughput RNA sequencing (RNA-seq). The differentially expressed genes (DEGs) between the HCCs cultured in Gel and MCG constructs have been identified via bioinformatics analysis. Significantly, the DEGs that promote cell proliferation (e.g. POSTN, MKI67, KIF20A) or neo-cartilage formation (e.g. COL2, ASPN, COMP, FMOD, FN1), are more highly expressed in MCG constructs than in Gel constructs, while the expressions of the DEGs associated with chondrocyte hypertrophy (e.g. EGR1, IBSP) are upregulated in Gel constructs. The expression of representative DEGs is verified at both mRNA and protein levels. Besides, cellular viability and morphology as well as the enriched signaling pathway of DEGs are studied in detail. These results of this work may provide data for functional tissue engineering of cartilage.