bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early life parameters and personality affect oxidative status during adulthood in an altricial rodent
Authors: Rödel Heiko G. , Jardim Veridiana , Rangassamy Marylin , Jaravel Ludivine , Jacquet Daphné , Monclús Raquel , Féron Christophe , Costantini David 
Published: October 2022

AbstractIt is increasingly recognized that alterations of the cellular oxidative status might be an important cost underlying challenging early life conditions. For example, an increased litter size can impose challenges as the offspring will face increased competition for maternal resources. Within a litter, individuals with relatively higher starting mass typically show higher growth rates, which can lead to increased oxidative damage. We investigated the long‐term consequences of these early life parameters on the oxidative status in mature mound‐building mice (Mus spicilegus). Individual differences in the animals' exploration tendency were assessed by repeated open field and novel object tests. We predicted less exploratory phenotypes, which typically show a higher stress responsiveness, to be particularly susceptible to possible effects of these early life parameters on oxidative status. We quantified oxidative damage of DNA (8‐hydroxy‐2'‐deoxyguanosine levels, 8‐OHdG) and proteins (protein carbonyl content, PCC), and activities of the antioxidants catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) in liver and skeletal muscle tissue. 8‐OHdG levels were positively associated with CAT and SOD in both tissues, indicating that increased oxidative DNA damage was associated with an upregulation of antioxidant production. Hepatic DNA damage after maturity was increased in animals from larger litters. In less exploratory animals, DNA damage and the activity of CAT and SOD in the muscle were increased, but only in individuals with higher relative starting mass (measured on postnatal day 9). This interaction may be explained by the typically higher adrenocortical activity in less exploratory phenotypes and by the higher growth in relatively heavier pups, two factors known to increase oxidative stress. These findings contribute to enlightening the complex interplay between early life conditions, personality, and oxidative status.
Exercise‐induced increase in M2 macrophages accelerates wound healing in young mice
Authors: Kawanishi Makoto , Kami Katsuya , Nishimura Yukihide , Minami Kohei , Senba Emiko , Umemoto Yasunori , Kinoshita Tokio , Tajima Fumihiro 
Published: October 2022

AbstractModerate‐intensity exercise performed during wound healing has been reported to decrease inflammatory cytokines and chemokines and accelerate wound healing. However, its effect on macrophage phenotype and the mechanism by which exercise accelerates wound healing remain unclear. The purpose of this study was to investigate the effect of exercise on macrophage phenotype during wound healing and to clarify the relationship between angiogenesis and wound healing. 12‐week‐old male C57BL/6J mice were divided into sedentary (n = 6) and exercise groups (n = 6). The exercise group performed moderate‐intensity treadmill running exercise (9.0 m/min, 60 min) for 10 days. Double immunofluorescence analysis was performed using F4/80+ inducible nitric oxide synthase (iNOS)+ for M1 macrophages, F4/80+ transforming growth factor‐beta (TGF‐β)1+ for M2 macrophages, and CD31+ alpha smooth muscle actin (α‐SMA)+ for angiogenesis. The exercise group showed significantly accelerated wound healing compared with the sedentary group. From early wound healing onward, exercise significantly inhibited M1 macrophage infiltration and increased M2 macrophage count. Exercise also significantly increased angiogenesis. Furthermore, the M2 macrophage phenotype was significantly correlated with angiogenesis in the exercise group, indicating that M2 macrophages and angiogenesis are related to accelerated wound healing. These findings suggest that moderate‐intensity exercise increases TGF‐β1 derived from M2 macrophages, which may be associated with enhanced angiogenesis and wound healing in young mice.
Changes in serum zinc and copper concentrations in patients with cardiovascular disease following cardiac surgery
Authors: Moravvej Zahra , Baradaran Rahimi Vafa , Azari Ali , Rahsepar Amir Ali , Ghayour‐Mobarhan Majid , Salehi Maryam , Bigdelu Leila 
Published: October 2022

AbstractThe trace elements copper (Cu) and zinc (Zn) are essential for maintaining oxidative balance, and cardiac surgery is known to provoke an increase in oxidative stress. We investigated the variations in serum Zn and Cu concentrations before and after surgery in patients undergoing on‐ and off‐pump CABG and heart valve replacement. We performed a prospective study on patients undergoing on‐ or off‐pump CABG, or heart valve replacement surgery (48, 51, and 47 patients, respectively). Venous blood samples were obtained, and serum Cu and Zn concentrations were measured preoperatively, 24 h postoperatively, and the time of discharge. In addition, echocardiography was carried out on all patients before surgery and again on the day of discharge. We found the temporal changes in Cu, Zn, and Zn/Cu ratio were significantly different in all three groups of surgery (p < 0.05). In each group, Cu and Zn values and Zn/Cu ratio decreased at the 24‐h postoperative time and rose at the discharge time. There were no significant differences between surgery groups in the changes induced in Zn or Cu values (p > 0.05). In conclusion, the concentrations of Cu and Zn were markedly reduced after on‐ and off‐pump CABG and valve replacement surgery. This may suggest that supplementary Zn and Cu administration could be beneficial during open‐heart surgeries. However, more long‐term studies with more patients are needed to confirm this hypothesis.
Modeling renal autoregulation in a hemodynamic, first‐trimester gestational model
Authors: van Ochten Maaike , Westerhof Berend E. , Spaanderman Marc E. A. , Antonius Tim A. J. , van Drongelen Joris 
Published: October 2022

AbstractThe maternal cardiovascular system, led by renal volume regulatory responses, changes during pregnancy to ensure an adequate circulation for fetal development and growth. Circulatory maladjustment predisposes to hypertensive complications during pregnancy. Mathematical models can be used to gain insight in the gestational cardiovascular physiology. In this study, we developed an accurate, robust, and transparent model for renal autoregulation implemented in an existing circulatory gestational model. This renal autoregulation model aims to maintain steady glomerular pressure by the myogenic response, and glomerular filtration rate by tubuloglomerular feedback, both by inducing a change in the radius, and thus resistance, of the afferent arteriole. The modeled response of renal blood flow and the afferent arteriole following blood pressure increase were compared to published observations in rats. With solely the myogenic response, our model had a maximum deviation of 7% in change in renal blood flow and 7% in renal vascular resistance. When both the myogenic response and tubuloglomerular feedback were concurrently activated, the maximum deviation was 7% in change in renal blood flow and 5% in renal vascular resistance. These results show that our model is able to represent renal autoregulatory behavior comparable to empirical data. Further studies should focus on extending the model with other regulatory mechanisms to understand the hemodynamic changes in healthy and complicated pregnancy.
Trust, Information and Pre-contractual Liability
Authors: Grundmann Stefan 
Published: October 2022

Abstract
This article explores on two ‘strangers’ for contract law – even though, at second sight, they both would seem truly seminal to contract law. This is, on the one hand, investment advice and more generally (pre-)contractual relationships on the giving of information in capital markets – arguably the largest market and contract segment in developed market economies, or at least one of the largest, but typically rather discussed only in specialised circles. This is, on the other hand, a broad pluralist interdisciplinary theory on trust in its relationship to information – largely underexplored and even missing in parts, even though absolutely core for all trust elements in contracts. There are not few of them. The core argument is that, if sociological, ethical and philosophical approaches are included, the outcome is grossly different from what ensues from the reference to the findings of institutional economics – so far dominant at least in financial services contracts. This is true namely for the desirable design of information, for the focus on specific groups of addressees and as well for the (traditionally rather high) prerequisites of pre-contractual liability.
Construction of complexiton-type solutions using bilinear form of Hirota-type
Authors: Kaplan Melike , Raza Nauman 
Published: October 2022

Abstract
In this paper, based on the Hirota bilinear form and the extended transformed rational function method, complexiton solutions have been found of the Hirota–Satsuma–Ito (HSI) equation and generalized Calogero–Bogoyavlenskii–Schiff equation through a direct symbolic computation with Maple. This method is the improved form of the transformed rational function method. The obtained complexiton solutions, includes trigonometric and hyperbolic trigonometric solutions, have verified utilizing Hirota bilinear forms. Also, a graphical representation of the obtained solutions is given.
Asymptotic behavior for stochastic plate equations with memory in unbounded domains
Authors: Yao Xiao Bin 
Published: October 2022

Abstract
In this paper, we investigate the dynamics of stochastic plate equations with memory in unbounded domains. More specifically, we obtain the uniform in time estimates for solutions of the problem. Based on the estimates above, we prove the existence and uniqueness of random attractors in unbounded domains. Finally, we show the upper semicontinuity of the attractors when stochastic perturbations approaches zero.
A linearized finite difference scheme for time–space fractional nonlinear diffusion-wave equations with initial singularity
Authors: Elmahdi Emadidin Gahalla Mohmed , Huang Jianfei 
Published: October 2022

Abstract
This paper presents a linearized finite difference scheme for solving a kind of time-space fractional nonlinear diffusion-wave equations with initial singularity, where the Caputo fractional derivative in time and the Riesz fractional derivative in space are involved. First, the considered problem is equivalently transformed into its partial integro-differential form. Then, the fully discrete scheme is constructed by using the Crank–Nicolson technique, the L1 approximation, and the convolution quadrature formula to deal with the temporal discretizations. Meanwhile, the classical central difference formula and the fractional central difference formula are applied to approximate the second-order derivative and the Riesz fractional derivative in space, respectively. Moreover, the stability and convergence of the proposed scheme are strictly proved by using the discrete energy method. Finally, some numerical experiments are presented to illustrate the theoretical results.
A Chebyshev collocation method for solving the non-linear variable-order fractional Bagley–Torvik differential equation
Authors: Amin Ahmed Z. , Lopes António M. , Hashim Ishak 
Published: October 2022

Abstract
A numerical approach based on the shifted Chebyshev–Gauss collocation method is proposed for solving the non-linear variable-order fractional Bagley–Torvik differential equation (VO-FBTE), subject to initial and boundary conditions. The shifted fractional Chebyshev–Gauss collocation points are used as interpolation nodes, and the solution of the VO-FBTE is approximated by a truncated series of the shifted Chebyshev polynomials. The residuals are calculated at the shifted fractional Chebyshev–Gauss quadrature points. The original VO-FBTE is converted into a system of algebraic equations. The accuracy of the proposed scheme is confirmed with a set of numerical examples, and the results are compared with those obtained by other methods.
Lie symmetry analysis for two-phase flow with mass transfer
Authors: Paliathanasis Andronikos 
Published: October 2022

Abstract
We perform a complete symmetry classification for the hyperbolic system of partial differential equations, which describes a drift-flux two-phase flow in a one-dimensional pipe, with a mass-transfer term between the two different phases of the fluid. In addition, we consider the polytropic equation of states parameter and gravitational forces. For general values of the polytropic indices, we find that the fluid equations are invariant under the elements of a three-dimensional Lie algebra. However, additional Lie point symmetries follow for specific values of the polytropic indices. The one-dimensional systems are investigated in each case of the classification scheme, and the similarity transformations are calculated in order to reduce the fluid equations into a system of ordinary differential equations. Exact solutions are derived, while the reduced systems are studied numerically.
The influence pulse-like near-field earthquakes on repairability index of reversible in mid-and short-rise buildings
Authors: Bavandi Mohammad 
Published: October 2022

Abstract
Conventional earthquake-resistant systems, often experience inelastic behavior in a part of the structure during a large earthquake and eventually causing residual deformation and damage to the structure. Repairing these damages are unaffordable and often leads to structure destruction. Therefore, the use of structures with the ability to focus damage on interchangeable elements, which leads to reduced earthquake damage, is very important. Due to the importance of the performance of self-centering structures to reduce their damage against various earthquakes, in this study, the Repairability Index of Post-tensioned Self-Centering Frame for Near-Field earthquake (RIPSCF-N) has been developed. According to the 12 models of the studied building, a building that can be repaired, that the maximum rotation in its connection after the earthquake does not exceed the rotation of the immediate occupancy performance. Based on this, the output data of Incremental Dynamic Analysis (IDA) in OpenSees were drawn according to the connection of relative rotation and spectral acceleration. According to the predicted performance levels of Garlock for each acceleration level, the value of the connection opening is divided by the opening of the Design Basis Earthquake (DBE) level. The resulting curve shows the repairability index according to spectral acceleration, which if less than one, the repairability target is achieved. To evaluate the damage of angles, the Angle Failure Probability of Post-tensioned Self-Centering Frame for Near-Field earthquake (AFPPSCF-N) has been developed. This index equation is determined according to the fragility curve and the intensity of damage in each building.
Insights into the protective capacity of human dental pulp stem cells and its secretome in cisplatin-induced nephrotoxicity: effects on oxidative stress and histological changes
Authors: Ranjbar Esmail , Tavakol Afshari Jalil , KhajaviRad Abolfazl , Ebrahimzadeh-Bideskan Alireza , Shafieian Reyhaneh 
Published: October 2022

Abstract

Objectives
Acute renal injury (AKI) is a major limiting factor for cisplatin administration. Recent evidence suggests the potential contribution of mesenchymal stem cells (MSCs) to rehabilitation from several disorders via both direct and indirect routes. Thus, the present study aimed, for the first time, to explore and compare the reno-protective potential of human dental pulp-derived stem cells (hDPSCs) vs. hDPSC-conditioned medium (hDPSC-CM) in recovery of impaired kidney tissues in a rat animal model of cisplatin-induced AKI.

Methods
AKI was induced via cisplatin injection (n=36). One day after, 24 rats were treated with either hDPSCs or hDPSC-CM (n=12). An extra set of rats (n=12) served as sham group. On days 2 or 7 (n=6), rats were humanly sacrificed for further analysis. Renal injury was explored via measuring serum creatinine and BUN. Renal level of oxidative stress was assessed by determining malondialdehyde, and enzymatic activities of superoxide dismutase and catalase. Renal histopathological changes were scored for comparison among different experimental groups.

Results
A single dose of cisplatin resulted in considerable renal dysfunction and oxidative stress. Treatment with hDPSCs or hDPSC-CM resulted in significantly restored renal function, reduced level of oxidative stress, and improved histopathological manifestations. Furthermore, as compared to hDPSC-CM, administration of hDPSCs led to superior results in AKI-induced animals.

Conclusions
The current study described the first comparative evidence of reno-protective potential of hDPSCs and their CM against cisplatin-induced nephrotoxicity in an AKI rat model, proposing them as useful adjunctive therapy in AKI. Yet, future explorations are still needed.
A randomized, double-blind, placebo-controlled, cross-over trial to evaluate the effect of EstroSense® on 2-hydroxyestrone:16α-hydroxyestrone ratio in premenopausal women
Authors: Green Tim , See Janet , Schauch Marita , Reil Julie , Glover Melissa , Brix Jennifer , Gerry Adella , Li Kathy , Newman Mark , Gahler Roland J. , Wood Simon 
Published: October 2022

Abstract

Objectives
Some estrogen metabolites are associated with increased breast cancer risk, while others are protective. Research efforts have focused on modifiable factors, including bioactive compounds found in food or supplements, promoting estrogen profiles with anti-cancer properties. EstroSense® is a nutraceutical product with bioactive compounds, including Indole-3-carbinol and green-tea catechins, which may favourably affect estrogen profiles. This study was conducted to determine if EstroSense use, compared to placebo, promotes a higher urinary 2-hydroxyestrone:16α-hydroxyestrone ratio (2-OHE1:16α-OHE1), a biomarker associated with a lowered risk of breast cancer.

Methods
A total of 148 premenopausal women were recruited from British Columbia, Canada to participate in a randomized, double-blind, cross-over, multicentre, placebo-controlled study in which women were randomized to a treatment sequence that consisted of either EstroSense®, followed by placebo or vice-versa. The women were instructed to consume three capsules per day of EstroSense® or the placebo for three menstrual cycles (∼12 weeks). The primary outcome was the measurement of 2-OHE1:16α-OHE1 in casual samples at baseline and after each treatment phase.

Results
After 12 weeks of intervention, the mean (95% CI) urinary 2-OHE1:16α-OHE1 was 4.55 (2.69, 6.42) (p<0.001) higher following EstroSense than placebo adjusted for baseline values.

Conclusions
EstroSense use led to markedly higher urinary 2-OHE1:16α-OHE1 than the placebo, a biomarker associated with a lower risk of breast cancer.

Registration

http://clinicaltrials.gov (NCT02385916).
Simulation design of automobile automatic clutch based on mechatronics
Authors: Chen Chao , Hernández Danaysa Macías , Martinez Silega Nemuri 
Published: October 2022

Abstract
This article aims to study the simulation and design of automobile automatic clutch under mechatronics. A new control strategy for the automatic clutch of the electromagnetic transmission is proposed. The clutch mechanism model, clutch drive model, clutch system model, and internal combustion engine model are constructed. The fuzzy logic control performance of the automatic clutch was verified in different operating modes, including starting on flat roads and mountain roads. The method provides a reasonable reference for the design of an automatic clutch of electromagnetic continuously variable transmission.
Pressurizer system dynamic model for transient control in PWR
Authors: Selim Hala K. , El-Sahlamy Neama M. 
Published: October 2022

Abstract
The pressurizer system of pressurized water reactor (PWR) maintains the reactor coolant system pressure during steady-state operation and limits pressure changes during transients. The in/out surge transients will cause pressure variations and they are controlled by either the spray system or the heater system. The spray system is actuated when the pressure exceeds a preset value. The heater system is initiated when the pressure falls below a preset value. The fundamental understanding and a reliable modeling of the pressurizer system behavior under steady state and transient conditions are needed to simulate overall nuclear power plant behavior. In the present study, an algorithm using Python 3.7 is developed to represent the dynamic behavior of the pressurizer system under steady-state and during in/out surge transients. Moreover, RELAP5 code is used to simulate the pressurizer system during the prescribed transients. The analysis and assessment results demonstrate satisfactory control performance during the in/out surge transients that guarantee the safety of PWR during operation. Also, the comparison between Python algorithm and RELAP5 model illustrates the capability and effectiveness of the Python algorithm for dynamic simulation and control.
Double domination in maximal outerplanar graphs
Authors: Zhuang Wei , Zheng Qiuju 
Published: October 2022

Abstract
In graph

G

G

, a vertex dominates itself and its neighbors. A subset

S
⊆
V

(

G

)

S\subseteq V\left(G)

is said to be a double-dominating set of

G

G

if

S

S

dominates every vertex of

G

G

at least twice. The double domination number

γ

×
2

(

G

)

{\gamma }_{\times 2}\left(G)

is the minimum cardinality of a double dominating set of

G

G

. We show that if

G

G

is a maximal outerplanar graph on

n
≥
3

n\ge 3

vertices, then

γ

×
2

(

G

)

≤

2
n

3

{\gamma }_{\times 2}\left(G)\le &#x230A;\frac{2n}{3}&#x230B;

. Further, if

n
≥
4

n\ge 4

, then

γ

×
2

(

G

)

≤
min

n
+
t

2

,
n
−
t

{\gamma }_{\times 2}\left(G)\le \min \left\{&#x230A;\frac{n+t}{2}&#x230B;,n-t\right\}

, where

t

t

is the number of vertices of degree 2 in

G

G

. These bounds are shown to be tight. In addition, we also study the case that

G

G

is a striped maximal outerplanar graph.
Existence and uniqueness of solutions to the norm minimum problem on digraphs
Authors: Wang Chong 
Published: October 2022

Abstract
In this article, based on the path homology theory of digraphs, which has been initiated and studied by Grigor’yan, Lin, Muranov, and Yau, we prove the existence and uniqueness of solutions to the problem

∥

w

∥

=

min

u
∈

Ω

2

(

G

)

,
u
≠
0

1

2

∥

∂
u
−
w

∥

2

2

+

∣

u

∣

1

\parallel w\parallel =\mathop{\min }\limits_{u\in {\Omega }_{2}\left(G),u\ne 0}\left\{\phantom{\rule[-1.25em]{}{0ex}},\frac{1}{2}{\parallel \partial u-w\parallel }_{2}^{2}+{| u| }_{1}\right\}

for

w
∈

H

1

(

G

)

w\in {H}_{1}\left(G)

and any digraph

G

G

generated by squares and triangles belonging to the same cluster.
Characterization of hydrogen assisted corrosion cracking of a high strength aluminum alloy
Authors: Yang Xiao , Liu Yan , Zhang Xian-feng , Li Xue-feng , Zhang Xin-yao , Gao Ling-qing 
Published: October 2022

Abstract
Environmentally and hydrogen assisted cracking can occur during application of high-strength aluminum alloys. However, there are only few suitable laboratory procedures to characterize and evaluate the environmentally and hydrogen assisted cracking behavior of materials. By optimizing the hydrogen charging parameters and slow strain rate, a multidimensional test procedure was established, which could simulate the actual working environment and could realize the test and evaluation of hydrogen assisted cracking susceptibility in the laboratory. Moreover, it provides a new environmental adaptability evaluation method for the high-strength aluminum alloy materials.