bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of clinical efficacy of continuous care with improved insulin injection techniques on patients with diabetes mellitus: a randomized controlled trial
Authors: Zhang Fang-Ying , Shen Mengyuan , Sun Li-Qin 
Published: June 2022

Objective To investigate the clinical effect of continuous care with improved insulin injection techniques on patients with diabetes mellitus. Methods This randomized controlled trial enrolled patients with diabetes mellitus. They were randomly assigned to a control or observation group. Patients in the control group received conventional continuous nursing. Patients in the observation group were given optimized insulin injection education and continuous nursing on the same basis as the conventional nursing used in the control group. Blood glucose-related outcomes, knowledge of insulin injections and adverse events were recorded. Results A total of 96 patients with diabetes mellitus were enrolled in the study ( n = 48 per group). There were no significant differences between the two groups in terms of sex, age and glycosylated haemoglobin (HbA1c). Compared with the control group, continuous care combined with optimized insulin injection techniques significantly reduced blood glucose target time, fasting blood glucose, 2-h postprandial blood glucose and HbA1c. The proportions of patients reporting a subcutaneous mass, insulin leakage and hypoglycaemic events were significantly lower in the observation group; and pain scores were significantly reduced compared with the control group. Conclusions Continuous care and optimization of insulin injection techniques can help patients achieve better diabetes-related outcomes. Study Registration Number: ChiCTR2200057166.
Effect of limited range of motion of the hip joint and leg-length discrepancy on gait trajectory: an experiment to reproduce the asymmetric gait that occurs in patients with osteoarthritis of the hip joint
Authors: Maezawa Katsuhiko , Nozawa Masahiko , Gomi Motoshi , Sato Hironobu , Hayashi Akito , Maruyama Yuichiro , Sugimoto Munehiko , Ishijima Muneaki 
Published: June 2022

Purpose: Although some symptoms that often occur with hip joint osteoarthritis (OA) may be involved in the appearance of gait disturbance, the main cause has not been identified. We hypothesised that the abnormalities in gait trajectory of patients with hip joint OA are mainly caused by limited range of motion of the hip joint or the presence of leg-length discrepancy, or both. To investigate this hypothesis, we examined whether the abnormal gait trajectory in patients with hip joint OA can be reproduced in healthy individuals by asking them to wear a hip orthosis and shoe orthotic (insole). Methods: We recruited 2 groups of participants: patients with hip joint OA (OA group, 38 patients) and healthy individuals who imitated patients with OA of the hip joint by wearing a hip orthosis or shoe orthotic (10-mm or 20-mm insole) or both (simulated OA group, 6 individuals). For gait analysis, we used a portable, wearable gait analyser with inertial sensors to evaluate 3-dimensional (3D) changes in gait trajectory. Results: In the OA group, the patterns of gait trajectories that were drawn on the 3 planes (coronal, sagittal, and horizontal planes) could be roughly divided into 3 types. The gait trajectories that were drawn when wearing a hip orthosis in the simulated OA group were very similar to 1 of the 3 patterns of gait trajectory that occurs in the OA group. Conclusions: We were able to reproduce the abnormal gait trajectory that is observed in ⅓ of patients with hip OA in healthy individuals, so we propose that an extreme reduction in hip joint ROM is 1 of the causes of abnormal gait pattern in patients with OA of the hip joint. A difference in leg length of 20 mm alone has little effect on gait trajectory.
Long-term safety and efficacy of ozanimod in relapsing multiple sclerosis: Up to 5 years of follow-up in the DAYBREAK open-label extension trial
Authors: Cree Bruce AC , Selmaj Krzysztof W , Steinman Lawrence , Comi Giancarlo , Bar-Or Amit , Arnold Douglas L , Hartung Hans-Peter , Montalbán Xavier , Havrdová Eva K , Sheffield James K , Minton Neil , Cheng Chun-Yen , Silva Diego , Kappos Ludwig , Cohen Jeffrey A 
Published: June 2022

Background: Ozanimod, an oral sphingosine 1-phosphate receptor 1 and 5 modulator, is approved in multiple countries for treatment of relapsing forms of MS. Objective: To characterize long-term safety and efficacy of ozanimod. Methods: Patients with relapsing MS who completed a phase 1‒3 ozanimod trial were eligible for an open-label extension study (DAYBREAK) of ozanimod 0.92 mg/d. DAYBREAK began 16 October 2015; cutoff for this interim analysis was 2 February 2021. Results: This analysis included 2494 participants with mean 46.8 (SD 11.9; range 0.033‒62.7) months of ozanimod exposure in DAYBREAK. During DAYBREAK, 2143 patients (85.9%) had treatment-emergent adverse events (TEAEs; similar in nature to those in the parent trials), 298 (11.9%) had a serious TEAE, and 75 (3.0%) discontinued treatment due to TEAEs. Serious infections (2.8%), herpes zoster infections (1.7%), confirmed macular edema cases (0.2%), and cardiac TEAEs (2.8%) were infrequent. Adjusted annualized relapse rate was 0.103 (95% confidence interval, 0.086‒0.123). Over 48 months, 71% of patients remained relapse free. Adjusted mean numbers of new/enlarging T2 lesions/scan and gadolinium-enhancing lesions were low and similar across parent trial treatment subgroups. Conclusions: This long-term extension of ozanimod trials confirmed a favorable safety/tolerability profile and sustained benefit on clinical and magnetic resonance imaging measures of disease activity.
Treatment outcomes of dialectical behaviour therapy for adolescents presenting with characteristics of borderline personality disorder: A naturalistic study
Authors: van der Hout Rebecca , Barnasconi Fleur , Noorloos Janet , de Bruin Rosanne , van Slobbe-Maijer Kim , Legerstee Jeroen , Oort Frans , Utens Elisabeth 
Published: June 2022

This naturalistic study investigated treatment outcomes of Dutch dialectical behaviour therapy for adolescents (DDBT-A) in a sample of 93 adolescents (95.4% female, mean age = 16.20 years) presenting with borderline characteristics, treated at Levvel (a Dutch mental health institution). From baseline to posttreatment significant decreases were found on severity of the borderline symptoms, passive coping style, internalizing and externalizing behavioural problems, and a significant increase on self-worth. Overall, three different therapy formats (outpatient, part-time therapy, and day therapy) showed similar improvements at posttreatment. Concluding, DDBT-A seems promising in reducing borderline related symptoms for adolescents.
A Heart Rate-Dependent Protocol of “One-Stop” Computed Tomography Angiography of Coronary Combined with Pulmonary Arteries Reduces the Dosages of Contrast Agent
Authors: Yu Hairong , Wang Hui , Gao Zhen , Chen Guoyue , Song Hao , Yan Shihao , Luan Xiaomei , Song Peiji 
Published: June 2022

Background: The personalized, heart rate-dependent computed tomography angiography (CTA) protocol can reduce the use of contrast medium (CM) and the radiation dose. This is especially beneficial for patients with CTA of coronary combined with pulmonary arteries. Purpose: To evaluate the feasibility of low CM in one-stop coronary and pulmonary arterial CTA tailored by patients’ heart rate. Material and Methods: 94 patients set to undergo CTA of coronary combined with pulmonary arteries with one-stop scans. Patients were prospectively randomized into two groups: For group A (n = 47), the timing of the scans was determined according to the patient’s HR using 30 mL CM; For group B (n = 47), in which the routine bolus tracking was applied by setting the ascending aortic threshold of 80 HU with 70 mL CM, scans were performed simultaneously. Results: Compared with group B, group A had slightly higher computed tomography (CT) value and image quality of pulmonary artery (CT value: group A 484.7HU; group B 457.9HU; t = 2.446, P = .016; image quality: χ2 = 8.292, P = .016), but in coronary artery wasn’t statistically different between two groups(image quality: χ2 = 2.516, P = .642). Conclusion: The heart rate-dependent CM injection protocol can greatly reduce the use of CM, simplify the work-flow, and may obtain comparable or even better image quality compared with the routine bolus tracking.
‘You’re not going to give a monkey’s chuff’: exploring co-production in the design of services for women who have experienced sexual violence
Authors: Warwick-Booth L , Cross R , Coan S , Fisher P 
Published: June 2022

Aims: Co-production is an emerging field in public health practice. We aim to present evidence of what works well to support co-production and what can be improved based upon learning from our evaluation of a co-production project implemented by Rape Crisis England and Wales (RCEW). RCEW designed and delivered a national co-production project called Weaving the Web, to inform the development of an online support service for women who have experienced sexual violence. Methods: We qualitatively evaluated the RCEW co-production approach. The specific objectives of our evaluation were to assess the increased role and voice for women and girls in co-producing services and provide better quality of evidence for what works in empowering women and girls. The evaluation was conducted in two phases: Phase 1 was the observation of co-production events ( n = 8), with findings from this used to develop an interview schedule for Phase 2, where semi-structured interviews ( n = 26) were conducted with a range of stakeholders (staff, partners and service users). Results: Staff supporting the co-production project were highly committed to the work, investing time, money, and preparation, and having a good understanding of co-production. Service users were less familiar with the approach and felt alienated by some of the language used. Most service users described participation as empowering and, in some instances, important in their own recovery. They were keen to stay involved beyond the creation of the online resource. Conclusion: The data from our evaluation illustrate that co-production on a national level is challenging. While RCEW used values-based practice, and provided a supportive culture to underpin the co-production of their online service, transformative engagement and true participation were not achieved. Learning from this project is drawn out here to outline transferrable lessons for practitioners intending to use models of co-production in other public health settings.
Challenges and opportunities of remote public involvement and community engagement during a pandemic: refining the MapMe childhood healthy weight intervention
Authors: McSweeney L , Arnott B , Jones A , Cain G , Jenkins J , Andras A , Adamson A 
Published: June 2022

Aims: Including parents and other stakeholders in the development of interventions to address the sensitive public health issues such as childhood obesity, through public involvement is critical. However, the Covid-19 pandemic has created a challenge for public involvement and engagement activities (PICE). The aim of this paper is to describe the process and challenges of setting up, maintaining, evaluating, and recording impact of three public and stakeholder groups via remote methods in the context of the MapMe2 study during the Covid-19 pandemic. Parental reaction to result letters received as part of the National Child Measurement Programme (NCMP) informing parents of their child’s overweight status is often one of hostility or disbelief. As a result, parents often do not act on these letters to address child overweight. The MapMe2 study is working in collaboration with the NCMP and local authorities, building on previous work (MapMe) and aims to support parents of primary school–aged children to recognise and maintain a healthy weight in their child. The existing MapMe Intervention includes an enhanced NCMP child weight result letter, supplemented with Body Image Scales (BIS), and an intervention website with material to support healthy eating, physical activity, and signposting supporting information. The intervention was to be refined and the evaluation informed with PICE input. Methods: Covid-19 restrictions meant that planned face-to-face PICE methods had to be altered with all recruitment, all correspondence, and activities taking place remotely. A Parent Involvement Panel (PIP), a child panel, and an expert panel were established. Several adaptations were made to accommodate a new way of involving the public in research. Results/Conclusions: Working remotely created many challenges and was a learning experience for all involved. However, an active group was successfully established. Using continuous assessment and evaluation methods, we were able to demonstrate successful involvement and engagement in the refinement of the MapMe2 study. Through the sharing of PICE methods practice, this paper adds to the literature, the value of partnership working.
Physician Flow at Work: Examining Work Absorption, Clinical Flow, Work Fulfillment, and Flow Thieves
Authors: Shreffler Jacob , Huecker Martin 
Published: June 2022

Background: The experience of “flow” at work correlates with positive job outputs and work-related attitudes. Very little current literature describes flow at work in physicians, who experience significant barriers to optimal work outputs, also known as flow thieves (e.g., case interruptions, documenting care). This study aimed to develop a measurement for physician flow (P-Flow) at work and examine the association of P-Flow with physician burnout, job satisfaction, and well-being. Methods: A pilot instrument was tested with items measuring P-Flow at work. After the pilot administration, a 14-item physician flow (P-Flow-14) scale was administered to physicians. In addition to the P-Flow-14 scale, physician respondents completed items measuring burnout, job satisfaction, and well-being. Results: This study specifies initial psychometric evidence of P-Flow-14 and 7-item P-Flow instruments for researchers interested in studying flow at work in physicians. For each P-Flow instrument, higher levels of the flow experience correlated with superior levels of well-being ( p < .01) and job satisfaction ( p < .01), and less burnout ( p < .001). Results showed initial psychometric evidence of derived subscales (work absorption, clinical flow, flow thieves, work fulfillment) for application in future research. Results showed associations between flow experience by age group and physician specialty. Conclusions/Application to Practice: To enhance well-being and job satisfaction, physicians should aim for concentration and immersion in clinical duties while reducing unnecessary distractions. These findings can be applied by employers and can guide further research on work interruptions and patient safety. Future research can validate the P-Flow scales and subscales to assess interventions aimed to improve the physician work environment.
An examination of temporal trends in health behaviors among United States children, adolescents, and adults from 2005 to 2016
Authors: Mubarak Naser , Wynn Austin , Tapasak Brandon , Collins Andrew , Mubarak Norah , Gonzalez Carla , Marino Gustavo , Mayne Stephanie 
Published: June 2022

Introduction Lifestyle-related health behaviors are major contributors to preventable chronic diseases. We aimed to characterize temporal trends in health behaviors of US children, adolescents, and adults and examine the association of sociodemographic characteristics with clustering of unhealthy behaviors. Methods The study population included 46,793 participants from the 2005 to 2016 National Health and Nutrition Examination Survey from three age groups: children (aged 2–11), adolescents (aged 12–19), and adults (aged ≥20). We calculated weighted prevalences of unhealthy behaviors—poor diet quality, low physical activity, screentime, fast food consumption, smoking (adolescents and adults), alcohol use, and short sleep duration (adults)—for each survey wave to examine temporal trends across age groups. Multivariable logistic regression estimated associations of sociodemographic characteristics with unhealthy behavior clustering (≥2 behaviors), stratified by age. Results Results of the study demonstrated that between 2005 and 2016, the proportion of children and adolescents not meeting the physical activity guidelines increased and screentime increased among all ages. Dietary quality improved and smoking prevalence declined among adolescents and adults, while fast food consumption declined among adolescents. Unhealthy behavior clustering among children increased by 13%. The odds of unhealthy behavior clustering were higher among children and adolescents that were older, non-Hispanic Black, or lived in unmarried households, and among adults who were younger, non-Hispanic black, had lower educational attainment, were uninsured or had public insurance, and had lower poverty-to-income ratios. Conclusion The findings suggest that screentime and physical inactivity are growing areas of concern in the U.S. population, and that disparities in adherence to multiple healthy behaviors may contribute to disparities in chronic diseases.
Posterior Vault Distraction for Multi-Suture Craniosynostosis in a Patient with Craniometaphyseal Dysplasia: A Case Report
Authors: Kennedy Diana , Loh Ian , Branson Helen M. , Forrest Christopher R. 
Published: June 2022

Study Design Case report Objective Syndromic multi-suture craniosynostosis can result in complex dysmorphology and increased intracranial pressure. We present a case report of a child with craniometaphyseal dysplasia and syndromic multi-suture craniosynostosis who presented with increased intracranial pressure, ventriculomegaly and Chiari deformity Type 1. Methods The child underwent a posterior vault distraction to increase the intracranial volume. Results The posterior cranial expansion was successful in correcting the craniocerebral disproportion caused by multi-suture synostosis, and resolved the high intracranial pressure and papilloedema. There were no post-operative complications. Conclusions Posterior cranial vault distraction was an effective method of addressing increased intracranial pressure by correcting craniocerebral disproportion by increasing intracranial volume and also addressing the Chiari Type I deformity that resulted from syndromic multi-suture craniosynostosis in a child with craniometaphyseal dysplasia.
International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data
Authors: Arber Daniel A. , Orazi Attilio , Hasserjian Robert P. , Borowitz Michael J. , Calvo Katherine R. , Kvasnicka Hans-Michael , Wang Sa A. , Bagg Adam , Barbui Tiziano , Branford Susan , Bueso-Ramos Carlos E. , Cortes Jorge E. , Dal Cin Paola , DiNardo Courtney D. , Dombret Hervé , Duncavage Eric J. , Ebert Benjamin L. , Estey Elihu H. , Facchetti Fabio , Foucar Kathryn , Gangat Naseema , Gianelli Umberto , Godley Lucy A. , Gökbuget Nicola , Gotlib Jason , Hellström-Lindberg Eva , Hobbs Gabriela S. , Hoffman Ronald , Jabbour Elias J. , Kiladjian Jean-Jacques , Larson Richard A. , Le Beau Michelle M. , Loh Mignon L.-C. , Löwenberg Bob , Macintyre Elizabeth , Malcovati Luca , Mullighan Charles G. , Niemeyer Charlotte , Odenike Olatoyosi M. , Ogawa Seishi , Orfao Alberto , Papaemmanuil Elli , Passamonti Francesco , Porkka Kimmo , Pui Ching-Hon , Radich Jerald P. , Reiter Andreas , Rozman Maria , Rudelius Martina , Savona Michael R. , Schiffer Charles A. , Schmitt-Graeff Annette , Shimamura Akiko , Sierra Jorge , Stock Wendy A. , Stone Richard M. , Tallman Martin S. , Thiele Jürgen , Tien Hwei-Fang , Tzankov Alexandar , Vannucchi Alessandro M. , Vyas Paresh , Wei Andrew H. , Weinberg Olga K. , Wierzbowska Agnieszka , Cazzola Mario , Döhner Hartmut , Tefferi Ayalew 
Published: June 2022

AbstractThe classification of myeloid neoplasms and acute leukemias was last updated in 2016 within a collaboration between the World Health Organization (WHO), the Society for Hematopathology, and the European Association for Haematopathology. This collaboration was primarily based on input from a clinical advisory committees (CACs) composed of pathologists, hematologists, oncologists, geneticists, and bioinformaticians from around the world. The recent advances in our understanding of the biology of hematologic malignancies, the experience with the use of the 2016 WHO classification in clinical practice, and the results of clinical trials have indicated the need for further revising and updating the classification. As a continuation of this CAC-based process, the authors, a group with expertise in the clinical, pathologic, and genetic aspects of these disorders, developed the International Consensus Classification (ICC) of myeloid neoplasms and acute leukemias. Using a multiparameter approach, the main objective of the consensus process was the definition of real disease entities, including the introduction of new entities and refined criteria for existing diagnostic categories, based on accumulated data. The ICC is aimed at facilitating diagnosis and prognostication of these neoplasms, improving treatment of affected patients, and allowing the design of innovative clinical trials.
Effects of endurance training on metabolic enzyme activity and transporter protein levels in the skeletal muscles of orchiectomized mice
Authors: Takahashi Kenya , Kitaoka Yu , Hatta Hideo 
Published: June 2022

AbstractThis study investigated whether endurance training attenuates orchiectomy (ORX)-induced metabolic alterations. At 7 days of recovery after sham operation or ORX surgery, the mice were randomized to remain sedentary or undergo 5 weeks of treadmill running training (15–20 m/min, 60 min, 5 days/week). ORX decreased glycogen concentration in the gastrocnemius muscle, enhanced phosphofructokinase activity in the plantaris muscle, and decreased lactate dehydrogenase activity in the plantaris and soleus muscles. Mitochondrial enzyme activities and protein content in the plantaris and soleus muscles were also decreased after ORX, but preserved, in part, by endurance training. In the treadmill running test (15 m/min, 60 min) after 4 weeks of training, orchiectomized sedentary mice showed impaired exercise performance, which was restored by endurance training. Thus, endurance training could be a potential therapeutic strategy to prevent the hypoandrogenism-induced decline in muscle mitochondrial content and physical performance.