bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Method for Relating Zircon Crystallisation to Petrogenetic Events
Authors: Miller Laura A , Cawood Peter A , Berry Andrew J 
Published: August 2022

Abstract
The trace element contents of zircon can provide unique insights into tectonothermal events, however, interpreting these data and identifying correlations with specific magmatic/metamorphic events can be challenging. This limits our ability to construct temporally constrained petrogenetic histories of complex metamorphic terranes. Unlocking the information that the rare earth element (REE) patterns of zircon contain is difficult because of the need to quantify differences. We have parametrised the shape of zircon REE patterns in terms of three independent parameters: average abundance, slope, and curvature. Quantifying REE patterns using independent shape parameters is similar to the use of REE ratios but is an improvement as (1) it uses information from all 14 REE rather than just two; (2) the use of two independent parameters (e.g. slope and curvature) is a more robust discriminant than the use of a single ratio; and (3) subtle variations in shape are easily distinguished enabling trends in the REE patterns of large datasets to be identified. Quantitative models were constructed showing how the shapes of the REE patterns of zircon change due to the co-crystallisation of other metamorphic minerals (monazite, apatite, and garnet). Diagnostic changes in shape enable the REE contents of zircon crystals or crystal zones to be accurately related to the growth of specific minerals and hence metamorphic events. The results were used to interpret the REE patterns of zircons from high-grade metamorphic terranes, which have experienced multiple deformation events (Val Malenco, Italy; Betic Cordillera, Spain; Seram, Indonesia; Lewisian Gneiss Complex, Scotland; Napier Complex, East Antarctica) and clearly identified zircon that crystallised in the presence of garnet. Quantitative comparison enabled zircon that crystallised prior to, synchronously with, or after garnet to be identified. Similar models can be used to interpret the REE patterns of monazite. This allows the relative timing of the growth of these minerals to be accurately constrained, which given the importance of zircon for geochronology and garnet for geobarometry has the potential to provide insights into the evolution of a metamorphic event.
An electroencephalogram biomarker of fentanyl drug effects
Authors: Balanza Gustavo A , Bharadwaj Kishore M , Mullen Andrew C , Beck Amanda M , Work Erin C , McGovern Francis J , Houle Timothy T , Eric T Pierce , Purdon Patrick L 
Published: August 2022

Abstract
Opioid drugs influence multiple brain circuits in parallel to produce analgesia as well as side effects, including respiratory depression. At present, we do not have real-time clinical biomarkers of these brain effects. Here, we describe the results of an experiment to characterize the electroencephalographic signatures of fentanyl in humans. We find that increasing concentrations of fentanyl induce a frontal theta band (4 to 8 Hz) signature distinct from slow-delta oscillations related to sleep and sedation. We also report that respiratory depression, quantified by decline in an index of instantaneous minute ventilation, occurs at ≈1700-fold lower concentrations than those that produce sedation as measured by reaction time. The electroencephalogram biomarker we describe could facilitate real-time monitoring of opioid drug effects and enable more precise and personalized opioid administration.
Generating string field theory solutions with matter operators from KBc algebra
Authors: Hata Hiroyuki , Takeda Daichi , Yoshinaka Jojiro 
Published: August 2022

Abstract
The KBc algebra is a subalgebra that has been used to construct classical solutions in Witten’s open string field theory, such as the tachyon vacuum solution. The main purpose of this paper is to give various operator sets that satisfy the KBc algebra. In addition, since those sets can contain matter operators arbitrarily, we can reproduce the solution of Kiermaier, Okawa, and Soler, and that of Erler and Maccaferri. Starting with a single D-brane solution on the tachyon vacuum, we replace the original KBc in it with an appropriate set to generate each of the above solutions. Thus, it is expected that the KBc algebra, combined with the single D-brane solution, leads to a more unified description of classical solutions.
Timing of MeCP2 Expression Determines Midbrain Dopamine Neuron Phenotype Specification
Authors: He Xi-Biao , Guo Fang , Li Kexuan , Yan Jiaqing , Lee Sang-Hun 
Published: August 2022

Abstract
Midbrain dopamine (DA) neurons are associated with locomotor and psychiatric disorders. DA phenotype is specified in ancestral neural precursor cells (NPCs) and maintained throughout neuronal differentiation. Here we show that endogenous expression of MeCP2 coincides with DA phenotype specification in mouse mesencephalon, and premature expression of MeCP2 prevents in vitro cultured NPCs from acquiring DA phenotype through interfering NURR1 transactivation of DA phenotype genes. By contrast, ectopic MeCP2 expression does not disturb DA phenotype in the DA neurons. By analyzing the dynamic change of DNA methylation along DA neuronal differentiation at the promoter of DA phenotype gene tyrosine hydroxylase (Th), we show that Th expression is determined by TET1-mediated de-methylation of NURR1 binding sites within Th promoter. Chromatin immunoprecipitation assays demonstrate that premature MeCP2 dominates the DNA binding of the corresponding sites thereby blocking TET1 function in DA NPCs, whereas TET1-mediated de-methylation prevents excessive MeCP2 binding in DA neurons. The significance of temporal DNA methylation status is further confirmed by targeted methylation/demethylation experiments showing that targeted de-methylation in DA NPCs protects DA phenotype specification from ectopic MeCP2 expression, whereas targeted methylation disturbs phenotype maintenance in MeCP2-overexpressed DA neurons. These findings suggest the appropriate timing of MeCP2 expression as a novel determining factor for guiding NPCs into DA lineage.
Scalp Nerve Block, Local Anesthetic Infiltration, and Postoperative Pain After Craniotomy: A Systematic Review and Network Meta-analysis of Randomized Trials
Authors: Luo Mengqiang , Zhao Xu , Deng Meng , Hu Yue , Yang Xiaoyu , Mei Zubing , Meng Lingzhong , Wang Yingwei 
Published: August 2022

The most efficacious methods for controlling postoperative pain in craniotomy remain unknown. A systematic review and network meta-analysis were performed to compare the efficacies of different strategies of scalp nerve block (SNB), scalp infiltration (SI), and control in patients undergoing craniotomy. MEDLINE, Embase, and CENTRAL databases were searched for randomized controlled trials. The primary outcome was postoperative 24-hour pain score, and the secondary outcome was opioid consumption within the first 24 hour after surgery. The effect was estimated using the between-group mean difference and ranked using the surface under the cumulative ranking curve (SUCRA) score. Twenty-four randomized trials were identified for inclusion. SNB using ropivacaine reduced postoperative 24-hour pain score when compared with control (mean difference [95% credible interval], –2.04 [–3.13, –0.94]; low quality), and when compared with SI using ropivacaine (–1.77 [–3.04, –0.51]; low quality) or bupivacaine (–1.96 [–3.65, –0.22]; low quality). SNB using ropivacaine was likely the most efficacious method for pain control (SUCRA, 91%), and also reduced opioid consumption within the first postoperative 24 hours as compared with control (mean difference [95% credible interval], –11.91 [–22.42, –1.4]; low quality). SNB using bupivacaine, lidocaine, and epinephrine combined, and SNB using ropivacaine, were likely the most efficacious methods for opioid consumption reduction (SUCRA, 88% and 80%, respectively). In summary, different methods of SNB / SI seem to have different efficacies after craniotomy. SNB using ropivacaine may be superior to other methods for postcraniotomy pain control; however, the overall quality of evidence was low.
Diagnosis and treatment of unusual multiorgan Echinococcus hydatid cysts
Authors: Drocchi Giovanni , Santucciu Cinzia , Mastrandrea Scilla , Sanguedolce Francesco , Madonia Massimo 
Published: August 2022

Abstract

Background
Echinococcosis is a zoonotic disease caused by Echinococcus granulosus. Usually, the liver is the most affected organ, accounting for approximately 70% to 85% of cases. The lungs represent 20% of the cases. Fewer than 10% are found in other sites, including the bone, brain, spleen, and kidneys.

Case presentation
A young man was referred to a local hospital for dull pain in the right flank, fever, and mild cough. Computed tomography showed 2 large cysts: the first involved the left lung and measured 130 × 90.5 × 120 mm, whereas the second cyst was located in the right kidney and measured 130 × 100 × 120 mm. Surgery was performed to remove both lesions in 2 separate surgical sessions.

Conclusions
Echinococcosis is a compulsorily notifiable disease. Collaboration between medical doctors from different specializations is necessary. A multidisciplinary approach is important for the correct therapeutic management of the disease. Furthermore, the high possibility of recurrence makes the long-term follow-up mandatory.
Skipping the Line: Inequality in Access to Developmental-Behavioral Care
Authors: McCafferty Shawna , Pereira-Smith Silvia , Koshy Anson J. , Valdez Purnima , Nyp Sarah S. 
Published: August 2022

CASE:
The mother of an 18-month-old boy contacted the developmental and behavioral pediatrics clinic to request an evaluation because of concerns that her son is not using any words and only recently began walking. The child's mother became upset when she was notified that the clinic policy requires receipt of a formal request for evaluation from the primary care physician and that the first available appointment was in 9 months. Later that day, the child's grandmother contacted the clinic and reported that she is a member of the Donor Society affiliated with the university/medical system. Membership in the Donor Society is granted to individuals who have met specific philanthropic thresholds benefiting the university. One benefit to members of the Donor Society is the ability to access subspecialty medical services for themselves and their family members, across all disciplines, within 5 business days of their request.
After confirming the details of the Donor Society promise with the philanthropic department of the hospital, a small committee of professionals within the clinic gathered to discuss the implications of this promised benefit to Donor Society members. This clinic is the only source for specialized, multidisciplinary developmental-behavioral health care that accepts public insurance within a 200-mile radius. The current waitlist for evaluation is 9 to 15 months depending on the reason for referral, and approximately 75% of patients on the waitlist receive some form of public assistance and/or live in a rural or underserved area. During the discussion, it was noted that there are 2 developmental-behavioral pediatric clinicians who practice within a cash-based private practice setting in the community. The waitlist for that practice was recently reported to be 3 to 6 months depending on the reason for evaluation, but that practice also requires a referral from the primary care physician before scheduling an initial evaluation.
How would you recommend that the clinicians in the developmental and behavioral pediatrics clinic respond to the request to fulfill the promises made by the university to members of the Donor Society? How does a promise such as this one made to the Donor Society affect structural inequalities within the health care system and what strategies could be used to mitigate further inequalities that may result?
Dynapenic-abdominal obesity as an independent risk factor for chronic kidney disease in postmenopausal women: a population-based cohort study
Authors: Choi Youngju , Cho Jinkyung , Kim Jiyeon , Bae Jun Hyun , Cho Eun-Jeong , Chang Eunwook , Joa Kyung-Lim , Kim Junghoon , Park Dong-Ho , Kang Ju-Hee , Kwak Hyo-Bum 
Published: August 2022

Abstract

Objective
Low muscle strength and obesity lead to a higher risk of chronic kidney disease (CKD). Perimenopause is associated with a natural decline in muscle strength and an increase in visceral adiposity. Dynapenic obesity, which is the coexistence of low muscle strength and obesity, is expected to synergistically increase the prevalence of CKD in postmenopausal women. The aim of this study was to determine combined associations of dynapenia and obesity with CKD in postmenopausal women.

Methods
This study used data from the Korean National Health and Nutrition Examination Survey, 2016 to 2019. The study included 4,525 postmenopausal women aged 42 to 80 years that were classified into four groups based on waist circumference (≥85 cm) and hand grip strength (<18 kg): normal, dynapenic, obese, or dynapenic-obese. According to the Kidney Disease: Improving Global Outcomes, we defined CKD as an estimated glomerular filtration rate <60 mL/min per 1.73 m2. Complex sample logistic regression models were conducted to determine the relationships among coexistence of dynapenia, abdominal obesity, and the risk of CKD.

Results
Dynapenic-abdominal obese group displayed lower estimated glomerular filtration rate levels than other groups (P < 0.05 for all data). The prevalence rates of CKD were 15.5%, 7.8%, 6.2%, and 2.4% in the dynapenic-abdominal obese, dynapenic, abdominal obese, and normal groups, respectively (P < 0.001). Complex sample logistic regression analyses, after adjusting for age, height, health behaviors, and comorbidities, showed that the odds ratio for CKD with respect to dynapenic-abdominal obesity was 1.82 (95% confidence interval, 1.19-2.79) and to abdominal obesity was 1.54 (95% confidence interval, 1.07-2.22) than in the normal group.

Conclusions
This study demonstrated that dynapenic-abdominal obesity, as determined by low handgrip strength and high waist circumference values, was associated with increased risk of CKD in postmenopausal women.
Nurses' Role in Addressing Social Determinants of Health
Authors: Ogbolu Yolanda 
Published: August 2022

Abstract
In recent years there has been increased interest in the social determinants of health (SDoH) by nurses and other healthcare professionals. Numerous seminars and discussions among nurses and other health professionals have focused on addressing social, economic, and environmental factors that impact the health and wellbeing of individuals and communities. Although these conversations are important and represent a movement towards health and social justice, they may be insufficient to address health inequities. There is an urgent need to move beyond community surveillance to implementing health equity programs and policies, especially in marginalized communities. Such is the case in Baltimore City, Maryland, where a nurse-led, community-based network of stakeholders transformed a grassroots health equity model to a state-mandated SDoH Taskforce focusing on a local community. The purpose of this column is to present a short case study that helps nurses understand their potential role in advancing health equity through policy.
The Lived Experience of Medication for Opioid Use Disorder
Authors: Techau Aimee , Gamm Emily , Roberts Mia , Garcia Lorraine 
Published: August 2022

Abstract

Purpose of the Study
Buprenorphine and methadone, when used as maintenance therapy in opioid use disorder (OUD), can significantly reduce the risk of death after an opioid overdose. Despite the many benefits, medication for OUD (MOUD) remains controversial and underutilized. The aim of this study was to (a) identify studies that explicate the lived experience of MOUD, (b) conduct a methodologically sound critical quality assessment, (c) conduct a metasynthesis of identified qualitative studies, and (d) analyze the results through the lenses of critical social justice, feminist standpoint, and social theories to inform a more culturally responsive, effective, and holistic approach to treatment to increase the utilization of and receptivity to MOUD in the treatment of OUDs.

Design and Methods
Metasynthesis is the deliberate process of synthesizing data from multiple qualitative studies to create a new interpretation of previously published research. Our metasynthesis focused on forming a new interpretation of the lived experience of MOUD. Of the 292 studies identified, eight met inclusion criteria. The overall quality of the studies was variable. The study population included adults aged ≥ 18 years with OUD or dependency.

Results
Metasynthesis produced three overarching themes: (a) The duplexity of MOUD creates ambivalence in how a person experiences MOUD; (b) the structure of treatment and systemic influences matter, and (c) MOUD as a stepping-stone with multiple meanings in recovery.

Implications
Understanding experiential dualities allows professionals to see from other perspectives and can inform interventions and treatment structures as well as serve as a backdrop for social change. The synthesized new meaning of MOUD was an ambivalent experience influenced by intersectionality.
Where It Really Counts
Authors: Parekh Tarang , Cuellar Alison E. , Farina-Morse Marissa , Spencer Nancy , Sutter Rebecca E. 
Published: August 2022

Abstract

Objective
The Peer Engaged Empowered Recovery (PEER) program is a county collaboration between specialty behavioral health and probation departments to address substance use and related problems by providing team-based peer recovery specialist (PRS) services. The study aimed to assess the feasibility and potential effectiveness of PEER and propose recommendations.

Method
Eligible clients released from jail had suspected substance use disorder and were assigned to the local drug court, on pretrial probation, or considered of high risk of recidivism. Clients were offered PRS support for 6 months. Client-reported data, administrative data on services, and survey data from program stakeholders were assessed.

Result
The program successfully identified clients with substance use disorder who had high to very high levels of need for social determinants of health, comorbid mental illness and other chronic conditions, and a high recidivism risk. Clients were served predominantly by phone despite complex needs. The sustainability of the PEER program was rated as stable along many dimensions except funding stability.

Conclusion
The PEER pilot program was well targeted. The average level of health and social need among clients was high, and many were difficult for PRS to contact. PRS services, which are currently undifferentiated in the state, may need to be risk-stratified in the future to take into account health and social factors and to align caseloads, reimbursement, and training.
Effects of Unemployment on Opioid Use Treatment Trajectories
Authors: Mumba Mercy Ngosa , Davis Lori , Smith Natalia Langer , Evans Teairra , Castillo Rachael 
Published: August 2022

Abstract
Living with an opioid use disorder (OUD) can make finding and sustaining employment a significant challenge and is only expected to get worse in the COVID-19 environment. For most individuals in OUD treatment, being employed is an important part of their recovery journey. Employment has several benefits, including reductions in preoccupation with symptoms, social isolation, risk of suicide, hopelessness, and economic instability, which if not addressed often result in homelessness. Therefore, employment is an important social determinant of health, especially among those with OUD. Employment success and OUD, however, may vary based on race, age, gender, and socioeconomic status. Return to work support as states begin to reopen will be critically important to improve treatment outcomes for individuals with OUD in a post-COVID-19 environment, requiring utilizations of evidence-based interventions. Nurses, particularly psychiatric mental health and addiction nurses, should routinely screen for employment needs of their patients with OUD and connect them to the necessary support services. Finally, nurses should advocate for regulatory reform that allows for employment support services to be billable and integrated in psychiatric and behavioral health services just like other mental health services.
Medications for Opioid Use Disorder During Incarceration
Authors: McDermott-Winger Erin R. , Latham Christine L. 
Published: August 2022

Abstract
The opioid epidemic has had a devastating impact on incarcerated individuals, with significantly higher rates of opioid use disorder (OUD) and risk of opioid overdose than the general public. Medications for OUD (MOUDs) are currently used with an interdisciplinary approach with good outcomes, but MOUD-approved medications are grossly underutilized in this population. Post incarceration, individuals without MOUDs have lessened their opioid tolerance after abstinence, resulting in staggering death rates or reincarceration from OUD. This article will describe the barriers within the criminal justice system that impede the provision of appropriate treatment for OUD. A structural intervention approach that addresses the barriers will be discussed, as well as patient outcomes associated with MOUDs, and recommendations for education, practice, and future research.
Addressing Disparities for Persons With Substance Use Disorders in Rural Communities
Authors: Heitkamp Thomasine L. , Fox LaVonne F. 
Published: August 2022

Abstract
This article provides an overview of the barriers to accessing intervention, treatment, and recovery supports for persons impacted by substances in rural communities. It defines “rural” and the complications of accessing intervention and treatment services in rural communities including the limitations of accessibility, availability, affordability, and acceptability of care. Ten suggestions, based on needs in rural communities and evidence-based practices, are outlined. They include suggestions for addressing the shortage of care providers in rural communities; educating and training professionals who are willing to adopt evidence-based practices; advancing a population health approach; addressing the limitation of substance use intervention and access to treatment because of stigma; adopting Screening, Brief Intervention, and Referral to Treatment and integrated care; ensuring support to address alcohol, stimulant, and opioid use disorder; offering culturally competent care; addressing the limitations of funding to access care in rural areas; and expanding the use of technology to deliver telehealth services. The recommendations are practical and support both the current and future health and behavioral health workforce serving people with substance use disorders in rural communities and health care administrators. If implemented, this will begin to address the disparities people residing in rural areas experience in securing treatment for substance use disorder and expand access to support for early intervention for people at risk through the adoption of evidence-based practices.