bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of eHealth‐based cognitive behavioural therapy on depression: A systematic review and meta‐analysis
Authors: Chan Ming , Jiang Ying , Lee Cheuk Yiu Charlotte , Ramachandran Hadassah Joann , Teo Jun Yi Claire , Seah Chuen Wei Alvin , Lin Yanjun , Wang Wenru 
Published: January 2022

AbstractAims and objectivesTo systematically appraise the effects of eHealth cognitive behavioural therapy on depression and anxiety severity, quality of life, adherence and attrition rates observed in adults with clinically diagnosed depression.BackgroundeHealth‐based cognitive behavioural therapy is an increasingly popular intervention on depression, but current reviews investigating the effects of eHealth interventions on depression are not exclusive to the clinically depressed.DesignA systematic review and meta‐analysis.MethodsFollowing the PRISMA guidelines, a systematic search of randomised controlled trials related to eHealth cognitive behavioural therapy published from inception from six databases and three trial registries was undertaken.ResultsA total of 15 studies were included in this systematic review. The meta‐analysis revealed that, when compared to passive comparators, eHealth cognitive behavioural therapy had a statistically significant effect on depression (d = −0.62, 95% CI: −0.96 to −0.28, p = .0003) and anxiety severity (d = −0.65, 95% CI: −1.10 to −0.21, p = .004) but not for quality of life (d = 0.30, 95% CI: −0.09 to 0.07, p = .13). When compared to active comparators, a statistically significant effect on depression (d = −0.31, 95% CI: −0.55 to −0.07, p = .01) and anxiety severity (d = −0.50, 95% CI: −0.81 to −0.19, p = .002) was observed, but not for quality of life (d = 0.22, 95% CI: −0.04 to 0.48, p = .10). Weighted averages for adherence and attrition rates were low.ConclusioneHealth cognitive behavioural therapy showed effectiveness in reducing depression and anxiety severity, but not quality of life. Further research is required to culturally adapt CBT interventions and explore the long‐term benefits of eHealth cognitive behavioural therapy.Relevance to clinical practiceThe use of eHealth‐based cognitive behavioural therapy could potentially bridge treatment gaps and serve as an adjunct to active treatment plans or an alternative for those without access to treatment.
Systematics of Mukdenia and Oresitrophe (Saxifragaceae): Insights from genome skimming data
Authors: Liu Lu‐Xian , Deng Pan , Chen Meng‐Zhen , Yu Li‐Min , Lee Joongku , Jiang Wei‐Mei , Fu Cheng‐Xin , Shang Fu‐De , Li Pan 
Published: January 2022

AbstractOresitrophe and Mukdenia (Saxifragaceae) are epilithic sister genera used in traditional Chinese medicine. The taxonomy of Mukdenia, especially of M. acanthifolia, has been controversial. To address this, we produced plastid and mitochondrial data using genome skimming for Mukdenia acanthifolia and Mukdenia rossii, including three individuals of each species. We assembled complete plastomes, mitochondrial CDS and nuclear ribosomal ETS/ITS sequences using these data. Comparative analysis shows that the plastomes of Mukdenia and Oresitrophe are relatively conservative in terms of genome size, structure, gene content, RNA editing sites and codon usage. Five plastid regions that represent hotspots of change (trnH‐psbA, psbC‐trnS, trnM‐atpE, petA‐psbJ and ccsA‐ndhD) are identified within Mukdenia, and six regions (trnH‐psbA, petN‐psbM, trnM‐atpE, rps16‐trnQ, ycf1 and ndhF) contain a higher number of species‐specific parsimony‐informative sites that may serve as potential DNA barcodes for species identification. To infer phylogenetic relationships between Mukdenia and Oresitrophe, we combined our data with published data based on three different datasets. The monophyly of each species (Oresitrophe rupifraga, M. acanthifolia and M. rossii) and the inferred topology ((M. rossii, M. acanthifolia), O. rupifraga) are well supported in trees reconstructed using the complete plastome sequences, but M. acanthifolia and M. rossii did not form a separate clade in the trees based on ETS + ITS data, while the mitochondrial CDS trees are not well‐resolved. We found low recovery of genes in the Angiosperms353 target enrichment panel from our unenriched genome skimming data. Hybridization or incomplete lineage sorting may be the cause of discordance between trees reconstructed from organellar and nuclear data. Considering its morphological distinctiveness and our molecular phylogenetic results, we strongly recommend that M. acanthifolia be treated as a distinct species.
The case for increased peritoneal dialysis utilization in low‐ and lower‐middle‐income countries
Authors: Okpechi Ikechi G. , Jha Vivekanand , Cho Yeoungjee , Ye Feng , Ijezie Chukwuonye I. , Jindal Kailash , Klarenbach Scott , Makusidi Muhammad A. , Okpechi‐Samuel Ugochi S. , Okwuonu Chimezie , Shah Nikhil , Thompson Stephanie , Tonelli Marcello , Johnson David W. , Bello Aminu K. 
Published: January 2022

AbstractPeritoneal dialysis (PD) has several advantages compared to haemodialysis (HD), but there is evidence showing underutilization globally, especially in low‐income and lower‐middle‐income countries (LLMICs) where kidney replacement therapies (KRT) are often unavailable, inaccessible, and unaffordable. Only 11% of all dialysis patients worldwide use PD, more than 50% of whom live in China, the United States of America, Mexico, or Thailand. Various barriers to increased PD utilization have been reported worldwide including patient preference, low levels of education, and lower provider reimbursement. However, unique but surmountable barriers are applicable to LLMICs including the excessively high cost of providing PD (related to PD fluids in particular), excessive cost of treatment borne by patients (relative to HD), lack of adequate PD training opportunities for doctors and nurses, low workforce availability for kidney care, and challenges related to some PD outcomes (catheter‐related infections, hospitalizations, mortality, etc.). This review discusses some known barriers to PD use in LLMICs and leverages data that show a global trend in reducing rates of PD‐related infections, reducing rates of modality switches from HD, and improving patient survival in PD to discuss how PD use can be increased in LLMICs. We therefore, challenge the idea that low PD use in LLMICs is unavoidable due to these barriers and instead present opportunities to improve PD utilization in LLMICs.
Mathematical modeling to inform the development of national guidelines on infant feeding in Thailand
Authors: Chittchang Uraiporn , Rojroongwasiukul Nipa , Winnichagoon Pattanee , Watson Louise , Ferguson Elaine 
Published: January 2022

AbstractThe development of national dietary guidelines promoting healthy food choices is a public health priority in Thailand. In developing the recent national complementary feeding guidelines (CFGs) for 6‐ to 12‐month‐old children, mathematical modeling was used to inform decisions. Model parameters were derived from nationally representative dietary data and analyzed for 11 micronutrients by age group, using linear programming analysis in Optifood. Models were run to identify micronutrients whose nutrient reference values could not be met using local foods as consumed (problem nutrients), evaluate the original 2012 Thai CFGs, and predict the nutritional benefits of a specific fortified complementary food. The results identified three problem nutrients (iron, calcium, and zinc), which, for 9‐ to 11‐month‐olds, were reduced to one when the fortified food was modeled. The number of servings/week of vegetables and meat, fish or eggs were higher, and of oil and fruit were lower, in the modeled nutritionally best rather than observed diets (medians). When modeled, the original Thai CFGs were not feasible because the energy constraint was exceeded; hence, in revising them, the recommended number of servings/week of oil and fruit were reduced. This study demonstrates the advantages of using mathematical modeling, when revising national CFGs, to evaluate and improve them.
Molecular docking of brazilin and its analogs to barrier‐to‐autointegration factor 1 (BAF1)
Authors: Correia Soeiro Maria de Nazaré , Vergoten Gérard , Bailly Christian 
Published: January 2022

AbstractThe tetracyclic phenolic compound brazilin, derived from the wood of Caesalpinia sappan, has been shown to bind to the chromatin protein BAF1 (barrier‐to‐autointegration factor 1), a protein essential to maintain integrity of the nuclear envelope in cells. BAF1 plays a role in cancer development. Using molecular docking, we have located the binding site for brazilin on the surface of the BAF1 monomer and compared its binding to that of four analogs. The oxidized product brazilein (ΔE = −57.7 kcal/mol) exhibits a higher affinity for BAF1 compared to the reduced form brazilin (ΔE = −38.2 kcal/mol). Incorporation of a 4‐hydroxyl substituent on the indenochromene unit affords hematoxylin and hematein. In silico analysis predicts that the oxidized form hematein (ΔE = −66.2 kcal/mol) displays a higher affinity for BAF1 than the reduced form hematoxylin (ΔE = −42.2 kcal/mol). In contrast, the atypical bis‐lactone product brazilide A cannot form good complexes with BAF1. The analysis points to the formation of more stable BAF1 complexes with the oxidized molecules compared to the reduced ones, but the position of the binding site on the protein cavity is different for brazilin/hematoxylin compared to brazilein/hematein. Our study may be useful to guide the design of BAF1 ligands.
Technical note: Sufficient operational statistics
Authors: Jia Justin , Katok Elena 
Published: January 2022

The decision in a data‐driven decision‐making problem is generally a high‐dimensional function of data. When can the decision be reduced to a single‐dimensional function of a statistic? This study addresses this question based on the operational statistics literature. The study introduces the notion of sufficient operational statistics and derives the factorization theorem for identifying such statistics. Further, the study proposes a solution procedure based on the statistics and derives the finite‐sample performance bound of the proposed solution.
Hydrogen sulfide‐mediated mitigation and its integrated signaling crosstalk during salinity stress
Authors: Srivastava Vikas , Chowdhary Aksar Ali , Verma Praveen Kumar , Mehrotra Shakti , Mishra Sonal 
Published: January 2022

AbstractEnvironmental stresses negatively affect plant development and significantly influence global agricultural productivity. The growth suppression due to soil salinity involves osmotic stress, which is accompanied by ion toxicity, nutritional imbalance, and oxidative stress. The amelioration of salinity stress is one of the fundamental goals to be achieved to ensure food security and better meet the issues related to global hunger. The application of exogenous chemicals is the imperative and efficient choice to alleviate stress in the agricultural field. Among them, hydrogen sulfide (H2S, a gasotransmitter) is known for its efficient role in stress mitigation, including salinity stress, along with other biological features related to growth and development in plants. H2S plays a role in improving photosynthesis and ROS homeostasis, and interacts with other signaling components in a cascade fashion. The current review gives a comprehensive view of the participation of H2S in salinity stress alleviation in plants. Further, its crosstalk with other stress ameliorating signaling component or supplement (e.g., NO, H2O2, melatonin) is also covered and discussed. Finally, we discuss the possible prospects to meet with success in agricultural fields.
An EEG study of the combined effects of top‐down and bottom‐up attentional selection under varying task difficulty
Authors: Rashal Einat , Senoussi Mehdi , Santandrea Elisa , Ben‐Hamed Suliann , Macaluso Emiliano , Chelazzi Leonardo , Boehler C. Nico 
Published: January 2022

AbstractWe examined the effect of combined top‐down and bottom‐up attentional control sources, using known attention‐related EEG components that are thought to reflect target selection (N2pc) and distractor suppression (PD). We used endogenous cues (valid vs. neutral) for top‐down attentional control, and salience in the form of color singletons (either the target or a distractor) for bottom‐up attentional control in visual search. Crucially, in two experiments, the task was of increasing difficulty, reporting the orientation of a tilted target (Experiment 1), or the position of a small gap within the target among tilted non‐targets (Experiment 2). Our results showed strong cueing effects on RT and accuracy in both experiments, demonstrating a general facilitation of responses to validly cued targets. Whereas the processing of salient targets was not improved compared with non‐salient targets, the presence of a salient distractor consistently worsened performance. The N2pc and PD were only observed in trials where targets were preceded by neutral cues in Experiment 1, and for validly cued targets and salient neutrally cued targets in Experiment 2. A cueing effect was found on the PD in Experiment 1, showing an amplitude reduction in trials where the target was validly cued. These results support the idea that bottom‐up attentional allocation occurs only when top‐down allocation of attention is absent or inefficient. Therefore, these results indicate that attentional selection and suppression during visual search are both influenced by top‐down cueing and give support to theories that focus on the interaction between the two types of attention.
The Role of Gender in Government and Nonprofit Workplaces: An Experimental Analysis of Rule Compliance and Supervisor Trust
Authors: Piatak Jaclyn , McDonald Jared , Mohr Zachary 
Published: January 2022

AbstractThe underrepresentation of women in leadership positions persists. Existing research examines barriers women face in climbing organizational hierarchies, but we know less about women who break past the glass ceiling. Once women obtain supervisory positions, do they face additional hurdles in managing employees? Specifically, how does gender, gender congruence, and rule formalization influence employee rule compliance and trust? Using a survey experiment across both government and nonprofit contexts, we find that both men and women are more likely to trust men managers, but this gender gap is mitigated when rules are written. Gender congruence plays a role for rule compliance, where both men and women are more compliant when the supervisor matches their gender, while gender congruence is only a significant factor for enhancing trust for men. The findings advance role incongruence theory and have implications for the challenges women leaders face in terms of trust and rule following.
The Impact of Demographic Composition of Social Networks on Perceived Inclusion in the Workplace
Authors: Jung Heyjie , Welch Eric W. 
Published: January 2022

AbstractInclusion in the workplace is defined as the extent to which individuals perceive that they are part of significant processes in organizations. This article explores the determinants of workplace inclusion by asking: How does the demographic composition of social networks inside and outside of the workplace affect perceived inclusion in the workplace? We apply literature on social identity theory and social network theory to develop and test hypotheses on professional sub‐network demographic composition using the linear regression analysis on data from the 2011 National Science Foundation–funded national survey of academic faculty on work environment and careers in US universities. Among other results, we find that perceived inclusion is explained by the interactions between race, gender, and demographic composition of professional networks. Findings provide new insights for the management of diversity in the workplace.
Who owns the pipes? Utility ownership, infrastructure conditions, and methane emissions in United States natural gas distribution
Authors: Scott Ryan P. , Scott Tyler A. , Greer Robert A. 
Published: January 2022

AbstractCritical infrastructure systems that provide local public services are owned by a complicated array of public and private entities that are subject to disparate regulatory regimes. Determining whether and why performance differences between public and private service providers emerge in these different contexts is critical for understanding the efficacy of current management efforts and informing policy choices about how to deal with public and private service providers. This paper analyzes a census of all U.S. gas distributors and a more detailed sample of the largest utilities in the United States to model how sector and regional market concentration relate to infrastructure quality and leak volumes. Using safety reports, market data, and yearly infrastructure records submitted by gas distributors from 2010 to 2017, the article uses a series of Bayesian hierarchical models to show that publicly owned utilities report lower quality infrastructure (i.e., operation of pipelines with lower quality materials),but alsoself‐report significantly lower leak rates, all else equal. The article concludes by discussing potential explanations for this discrepancy, including the capital investment incentives private utilities face under cost‐of‐service pricing regulations and the fact that performance measurement capacity is itself a potential outgrowth of increased investment and expenditures.
The use of general anaesthesia in special care dentistry: A clinical guideline from the British Society for Disability and Oral Health
Authors: Geddis‐Regan Andrew R. , Gray Deborah , Buckingham Sarah , Misra Upma , Boyle Carole ,   the British Society for Disability and Oral Health
Published: January 2022

AbstractBackgroundGeneral anaesthesia (GA) may be required to support the care of those seen in Special Care Dentistry (SCD) services for various reasons, such as enabling extensive dental care for people with severe learning disabilities or severe dental phobia. Guidance is needed for teams delivering SCD using GA due to the potential risks, implications, and costs of using GA to deliver dental care.AimTo present evidence‐based recommendations, where possible, for teams involved in providing GA for dental care for adults within SCD services.MethodsA multidisciplinary working group, supported by a formal literature search and stakeholder involvement, iteratively produced and refined the recommendations presented.ResultsThere was little evidence to inform the guidelines. Recommendations are therefore based mainly on the working group's expert consensus opinion. Clinical guidelines are presented as a set of overarching principles followed by six key sections reflecting patients' pathways from referral to dental services through to their care during and after GA.ConclusionGuidelines are presented to support those providing GA to provide SCD. The need for comprehensive and person‐centered assessment and planning is emphasized.
Immune gene activation by NPR and TGA transcriptional regulators in the model monocot Brachypodium distachyon
Authors: Shimizu Kohei , Suzuki Hitomi , Uemura Takuya , Nozawa Akira , Desaki Yoshitake , Hoshino Ryosuke , Yoshida Ayako , Abe Hiroshi , Nishiyama Makoto , Nishiyama Chiharu , Sawasaki Tatsuya , Arimura Gen‐ichiro 
Published: January 2022

SUMMARYThe nonexpressor of pathogenesis‐related (NPR) gene family is well known to play a crucial role in transactivation of TGA transcription factors for salicylic acid (SA)‐responsive genes, including pathogenesis‐related protein 1 (PR1), during plants' immune response after pathogen attack in the model dicot Arabidopsis thaliana. However, little is known about NPR gene functions in monocots. We therefore explored the functions of NPRs in SA signaling in the model monocot Brachypodium distachyon. BdNPR1 and BdNPR2/3 share structural similarities with A. thaliana AtNPR1/2 and AtNPR3/4 subfamilies, respectively. The transcript level of BdNPR2 but not BdNPR1/3 appeared to be positively regulated in leaves in response to methyl salicylate. Reporter assays in protoplasts showed that BdNPR2 positively regulated BdTGA1‐mediated activation of PR1. This transactivation occurred in an SA‐dependent manner through SA binding at Arg468 of BdNPR2. In contrast, BdNPR1 functioned as a suppressor of BdNPR2/BdTGA1‐mediated transcription of PR1. Collectively, our findings reveal that the TGA‐promoted transcription of SA‐inducible PR1 is orchestrated by the activator BdNPR2 and the repressor BdNPR1, which function competitively in B. distachyon.
One-Pot Pyrolysis to Nitrogen-Doped Hierarchically Porous Carbon Nanosheets as Sulfur-Host in Lithium–Sulfur Batteries
Authors: Zha Cheng , Liu Shuhe , Zhou Liexing , Li Kongzhai , Zhang Tianyu 
Published: January 2022

Abstract
Lithium–sulfur battery is a promising energy storage device because of its high theoretical specific energy density, low cost, and environmental friendliness. Here, we prepared nitrogen-doped hierarchically porous carbon nanosheets (N-PCNS) by NaCl salt-assisted one-pot pyrolysis strategy, using NaCl, glucose, and melamine as template, carbon and nitrogen as source. Using N-PCNS hosted sulfur composite material (N-PCNS/S) as the cathode material of the lithium–sulfur battery, the first specific discharge capacity at 0.2 C is 956.7 mA h g−1, and the reversible capacity after 100 cycles is 625.9 mA h g−1, with the capacity loss of 0.34% per cycle. At the high rate of 0.5 C, the specific capacity of the first discharge is still 717.3 mA h g−1. This study provides a simple and feasible strategy for the preparation of cathode materials for lithium–sulfur batteries.
Internet-based platform for a low-calorie dietary intervention involving prepackaged food for weight loss in overweight and obese individuals in China: protocol for a randomised controlled trial
Authors: Wang Xi , Wang Suyuan , Zhang Chenghui , Zhong Lingyu , Lerman Lilach , Lerman Amir , Guo Yanhong , Wu Yunhong , Lopez-Jimenez Francisco 
Published: January 2022

IntroductionObesity is a global health issue that impacts quality of life. A calorie-restricted diet with high-intensity consultation provided via the internet may be an effective way to lose weight. The objective of this study was to assess the effectiveness of a practitioner-guided, mobile internet-based low-energy dietary intervention in overweight and obese populations in China.Methods and analysisThis open-label randomised controlled trial enrolled 220 overweight and obese adults aged 18–70 years who met the inclusion criteria. Participants were assigned to the control group (n=110) or trial group (n=110). The trial group will be enrolled in the MetaWell programme, a weight loss programme using diet replacement products, wireless scales and a mobile phone app. Participants in the control group will receive paper material containing a sample diet for weight loss. The follow-up period will be 1 year, and measurements will occur at 3, 6 and 12 months. Dual-emission X-ray absorptiometry and abdominal quantitative CT will be performed to estimate the percentage of overall body fat and areas of visceral and subcutaneous fat, alongside several cardiometabolic measurements. The primary outcome of this study is the change in body mas index (BMI) at 6 months after enrolment. A mixed-effects model will be used to compare BMI and body fat changes between the two groups.Ethics and disseminationThis study was approved by the ethics committee of the Hospital of Chengdu Office of the People’s Government of the Tibetan Autonomous Region. Advertisements for recruitment will be sent via official accounts using WeChat. The results will be disseminated via publications in academic journals and our clinic. Our study group will maintain contact with the participants to inform them of the study findings.Trial registration numberChiCTR1900021630.