bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rutin Inhibits Cardiac Apoptosis and Prevents Sepsis-Induced Cardiomyopathy
Authors: Meng Xiang-Long , Yu Mu-Ming , Liu Yan-Cun , Gao Yu-Lei , Chen Xin-Sen , Shou Song-Tao , Chai Yan-Fen 
Published: April 2022

Rutin is a flavanol-type polyphenol that consists of flavanol quercetin and the disaccharide rutinose, which has been reported to exert various biological effects such as antioxidant and anti-inflammatory activities. It is not clear whether rutin has a protective effect on sepsis-induced cardiomyopathy (SIC). In this study, we used male C57BL/6 mice and cecal ligation and puncture (CLP) surgery to establish the model of SIC. Rutin was precautionarily treated (50, 100, 200 mg/kg per day, 7 days) before CLP. The results showed that rutin pretreatment (100, 200 mg/kg per day, 7 days) reduced the mortality of murine sepsis. We chose the 100 mg/kg dose for further studies. Mice were pretreatment with rutin (100 mg/kg per day, 7 days) before subjected to CLP, and myocardial tissue and blood samples were collected 24 h after CLP. Serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and cTNT decreased, while interleukin-10 (IL-10) increased with rutin pretreatment. The cardiomyocytes apoptosis and mitochondrial dysfunction were also alleviated with rutin pretreatment. In conclusion, this study confirmed the efficacy of rutin-enriched diet in the prophylaxis of cardiac apoptosis and cardiac injury induced by CLP in mouse model. It provides a potential new approach on SIC prophylaxis in sepsis.
Association of Plasma Bilirubin Levels With Peripheral Arterial Disease in Chinese Hypertensive Patients: New Insight on Sex Differences
Authors: Shi Yumeng , Zhou Wei , Cheng Mingshu , Yu Chao , Wang Tao , Zhu Lingjuan , Bao Huihui , Hu Lihua , Li Ping , Cheng Xiaoshu 
Published: April 2022

Background and aims: Previous studies have indicated that Plasma total bilirubin (TBiL) might play an essential role in peripheral arterial disease (PAD). However, the effects of different levels of TBiL on PAD development remain uncertain. We aimed to examine the TBiL and the prevalence of PAD among Chinese adults with hypertension, with particular attention paid to sex differences.Methods: A total of 10,900 hypertensive subjects were included in the current study. The mean age of our study participants was 63.86 ± 9.25 years, and there were 5,129 males and 5,771 females. The outcome was peripheral arterial disease (PAD), defined as present when the ankle-brachial index (ABI) of either side was ≤0.90. The association between TBiL and PAD was examined using multivariate logistic regression analysis and the restricted cubic spline.Results: Of 10,900 hypertensive participants, 350 (3.21%) had PAD, and the mean plasma total bilirubin was 14.66 (6.86) μmol/L. The mean TBiL was 15.67 μmol/L in men and 13.76 μmol/L in women. The smoothing curve showed that a U-shaped curve association existed between TBiL and the prevalence of PAD in Chinese adults with hypertension. When stratified by sex, TBiL was significantly U-shaped associated with PAD among men but not women. Among males, the inflection point was 11.48 μmol/L; to the left inflection point, the effect size and 95% CI were 0.08, 0.01, 0.66, respectively; to the right inflection point, OR, 5.16; 95% CI,1.64, 16.25.Conclusions: We found an independent U-shaped association between TBiL and the prevalence of PAD among hypertensive subjects and a differential association between men and women. We further revealed a turning point by threshold effect analysis.
Positive Mental Health Literacy: A Concept Analysis
Authors: Carvalho Daniel , Sequeira Carlos , Querido Ana , Tomás Catarina , Morgado Tânia , Valentim Olga , Moutinho Lídia , Gomes João , Laranjeira Carlos 
Published: April 2022

BackgroundThe positive component of Mental Health Literacy (PMeHL) refers to a person’s awareness of how to achieve and maintain good mental health. Although explored recently, the term still lacks a clear definition among healthcare practitioners.AimTo identify the attributes and characteristics of PMeHL, as well as its theoretical and practical applications.MethodsLiterature search (using the Medline and CINAHL databases) and review, covering the last 21 years, followed by concept analysis according to the steps described by Walker and Avant approach.ResultsPositive component of Mental Health Literacy is considered one component of MHL, integrating positive mental health. The concept’s attributes include: (a) competence in problem-solving and self-actualization; (b) personal satisfaction; (c) autonomy; (d) relatedness and interpersonal relationship skills; (e) self-control; and (f) prosocial attitude. Four case scenarios (model, borderline, related and contrary cases) were used to clarify the antecedents (individual factors and social/contextual factors) and consequences (individual sphere; relational/social sphere; contextual/organizational sphere) of PMeHL.ConclusionPositive component of Mental Health Literacy is considered a component of MHL, which deserves attention throughout the lifespan, in different contexts and intervention levels. Considering PMeHL as a multi-faceted and dynamic construct will help understand the mechanisms that improve mental health and promote healthy behaviors. Priority should be given to robust primary research focused on nursing interventions that enhance and sustain PMeHL in people and families.
Multi-Level Social Capital and Subjective Wellbeing Among the Elderly: Understanding the Effect of Family, Workplace, Community, and Society Social Capital
Authors: Xu Zongyou , Zhang Wenjie , Zhang Xuewen , Wang Yixi , Chen Qing , Gao Bo , Li Ningxiu 
Published: April 2022

BackgroundMaintaining the subjective wellbeing of the elderly people is one of the major concerns in promoting health aging. This study concerned the influence of multi-level social capital on subjective welling and explored the affecting path among the elderly.MethodsA total of 1,078 elderly individuals anonymously and effectively surveyed in 2018, data was collected including their family, workplace, community, society social capital and subjective wellbeing, we used the structural equation modeling to test the hypothesis relationships among the variables.ResultsWe found that the total score of subjective wellbeing among the aging participants was 72.36 ± 10.08 on a range of 0–100. Family (β = 0.151, P &lt; 0.001), workplace (β = 0.090, P &lt; 0.001), community (β = 0.163, P &lt; 0.001) social capital had a direct positive effect on subjective wellbeing. Society social capital had a direct positive effect on family (β = 0.253, P &lt; 0.001), workplace (β = 0.585, P &lt; 0.001), community (β = 0.438, P &lt; 0.001) social capital. And society social capital had an indirect positive effect on subjective wellbeing through the mediating role of family, workplace, and community social capital.ConclusionThe research demonstrated that all the micro, meso and macro levels of social capital have protective effects for subjective wellbeing through direct or indirect way, inspiring to provide continuous improvement measures for multi-level social capital aimed at the elderly people.
Urban-Rural Differences: The Impact of Social Support on the Use of Multiple Healthcare Services for Older People
Authors: Chi Zhang , Han Hu 
Published: April 2022

BackgroundThere are many kinds of chronic diseases, high incidence and high hospitalization rate in older people caused by population aging. The increasing demand for healthcare services has become an increasingly prominent problem in Chinese society. The purpose of this paper is to explore the influence of social support on multiple healthcare services for older people and the urban-rural differences among them.MethodsThe data are from our field survey in Shaanxi province in 2019. Using the Anderson model as the basic explanatory framework, this paper uses the Tobit-model to analyses the impact of social support for older people on the utilization of therapeutic healthcare services, and the Logit-model to analyze the impact of living arrangements and social support on the utilization of preventive healthcare services for older people.ResultsThis paper examines the impact of formal and informal support on outpatient, inpatient, and preventive healthcare services for older people, provides an in-depth analysis of the differences in the impact of social support on healthcare service utilization between urban and rural older people and analyses the contribution of various factors to the impact. The coefficient effect is divided into two parts: the coefficient “premium” of urban older people relative to urban and rural older people as a whole, which accounts for 10.8% of the total difference; and the “premium” of urban and rural older people as a whole to rural older people, which accounts for 18.9% of the total difference. The coefficient effect accounts for 29.7 per cent of the total difference.ConclusionsRural older people place greater importance on the quantity of formal social support, while urban older people place greater importance on the quality of formal social support. The phenomenon of raising children for old age was evident in the use of healthcare services by rural older people, while the phenomenon of distant relatives being better than close neighbors was evident in the use of healthcare services by urban older people. Free preventive healthcare services in rural China have largely compensated for the lack of health benefits for rural older people.
The Prevalence of Irritable Bowel Syndrome Among Chinese University Students: A Systematic Review and Meta-Analysis
Authors: Yang Weixin , Yang Xiao , Cai Xianghao , Zhou Zhuoren , Yao Huan , Song Xingrong , Zhao Tianyun , Xiong Peng 
Published: April 2022

BackgroundIrritable bowel syndrome (IBS) has become a common public health issue among university students, impairing their physical and mental health. This meta-analysis aimed to examine the pooled prevalence of IBS and its associated factors among Chinese university students.MethodsDatabases of PubMed, EMBASE, MEDLINE (via EBSCO), CINAHL (via EBSCO), Wan Fang, CNKI and Weipu (via VIP) were systematically searched from inception date to May 31, 2021. Meta-analysis was performed using random-effects models. Meta-regression and subgroup analysis were used to detect the potential source of heterogeneity.Key ResultsA total of 22 cross-sectional studies (14 were in Chinese and 8 were in English) with 33,166 Chinese university students were included. The pooled prevalence of IBS was estimated as 11.89% (95% CI = 8.06%, 16.35%). The prevalence was 10.50% (95% CI = 6.80%, 15.87%) in Rome II criteria, 12.00% (95% CI = 8.23%, 17.17%) in Rome III criteria, and 3.66% (95% CI = 2.01%, 6.60%) in Rome IV criteria. The highest prevalence of IBS was 17.66% (95% CI = 7.37%, 36.64%) in North China, and the lowest was 3.18% (95% CI = 1.28%, 7.68%) in South China. Subgroup analyses indicated that gender, major, anxiety and depression symptoms, drinking and smoking behaviors were significantly associated with the prevalence of IBS. Meta-regression analyses suggested that region influenced prevalence estimates for IBS.Conclusions and InferencesThis meta-analysis illustrated that IBS is very common in Chinese university students. Regular screening, effective prevention, and appropriate treatments should be implemented to reduce the risk of IBS in this population. More future studies should be conducted in Northeastern and Southwestern parts of China.
Identification of microRNA Transcriptome Involved in Bovine Intramuscular Fat Deposition
Authors: Duckett Susan K. , Greene Maslyn A. 
Published: April 2022

BackgroundIntramuscular fat deposition in beef is a major determinant of carcass quality and value in the USA. The objective of this study was to examine changes in microRNA (miRNA) transcriptome that are involved with intramuscular fat deposition with time-on-concentrates (TOC). Yearling steers were individually fed a high concentrate diet and changes in intramuscular fat deposition were monitored by real-time ultrasound at 28 to 33 d intervals. Longissimus muscle biopsies collected on d 0, 92 and 124 TOC to examine changes in miRNA transcriptome that are involved in intramuscular fat deposition.ResultsSteer body weight increased (P &lt; 0.0001) at each weigh day during TOC. Fat thickness increased (P &lt; 0.005) from d 28 to 124. Ribeye area was larger (P &lt; 0.001) on d 124 than d 61, which was larger than d 0 and 28. Ultrasound intramuscular fat content was greater (P &lt; 0.001) on d 92 and 124 compared to d 0, 28 or 61. Sequencing of the muscle biopsy samples identified one miRNA, bta-miR-122, that was up-regulated (P &lt; 0.005) at d 92 and 124 compared to d 0. At d 92 TOC, mRNA expression levels of fatty acid binding protein 4 (FABP4) and elongase 6 (ELOVL6) were up-regulated (P &lt; 0.01) compared to d 0; whereas at d 124, lipogenic genes involved in de novo fatty acid synthesis, fatty acid transport, elongation and desaturation were highly up-regulated compared to d0.ConclusionsSmall RNA sequencing identified bta-miR-122 as a potential miRNA of interest that may be involved in intramuscular fat deposition with increasing TOC. Increased intramuscular fat content, as measured by real-time ultrasound, combined with differential gene expression suggests that preadipocyte differentiation may be stimulated first, which is followed by a global up-regulation of lipogenic genes involved in de novo fatty acid synthesis that provide fatty acids for subsequent hypertrophy.
Genetic Parameters of Somatic Cell Score in Florida Goats Using Single and Multiple Traits Models
Authors: Jimenez-Granado Rocío , Molina Antonio , Ziadi Chiraz , Sanchez Manuel , Muñoz-Mejías Eva , Demyda-Peyrás Sebastián , Menendez-Buxadera Alberto 
Published: April 2022

A total of 1,031,143 records of daily dairy control test of Spanish Florida goats were used for this study. The database was edited, and only the records of the first three lactations were kept. The final database contained 340,654 daily-test somatic cell counts from 27,749 daughters of 941 males and 16,243 goats. The evolution of this count in the last 14 years was analyzed following French and American international associations’ criteria for the risk of mastitis in goats, and confirmed the slight increase in SCS in the last years and the importance of this problem (50% of dairy control tests show a risk of suffering mastitis). For the genetic analysis, the SCS records were log-transformed to normalize this variable. Two strategies were used for the genetic analysis: a univariate animal model for the SCS assuming that SCS does not vary throughout the parities, and a multi-character animal model, where SCS is not considered as the same character in the different parities. The heritabilities (h2) were higher in the multiple traits models, showings an upward trend from the first to the third parity (h2 between 0.245 to 0.365). The genetic correlations of the same trait, as well as between breeding values (GVs) between different parities, were different from unity. The breeding values (EBVs) obtained for both models were subjected to a PCA: the first eigenvector (λ1) explained most of the variations (between 74% to 90%), while the second λ2 accounted for between 9% to 20% of the variance, which shows that the selection will be proportionally favorable but not equivalent in all parities and that there are some variations in the type of response.
Innovation against gender inequalities in agri-food industry
Authors: Modaffari Giuseppe , Manzo Martina 
Published: April 2022

In recent years, industrialization and globalization have prompted small and medium-sized enterprises (SMEs) to implement a significant technological and managerial innovation process. In Italy, it leads to new entrepreneurial pathways, such as innovative start-ups. The new solutions' implementation becomes even more crucial for a company's sustainability during crises since it improves the organization's flexibility and encourages the development of new tools and techniques. Previous research recognized the intangible assets' relevance in the innovation's creation process, mainly referring to Intellectual Capital (IC) and its components. In particular, Relational Capital (RC) fosters reactive firms' resilience, whereas Structural Capital (SC) helps SMEs respond to challenges proactively. Focusing on the agri-food sector, it has recently reached considerable results in terms of innovation, but it still appears insufficient to stimulate female entrepreneurship. Recent data confirm a remarkable gender gap: for 107 innovative agri-food start-ups in Italy, only 14 are led by women.
Given all this, the paper aims to answer the following Research Questions (RQ).
RQ1: How could RC and SC promote women innovative start-ups in agri-food?
RQ2: How did these factors foster proactive and reactive firms' resilience during the pandemic?
The work uses an exploratory, descriptive qualitative analysis performed during the pandemic emergency and applies the CAOS model, an interpretative model widely used in SMEs' studies since it allows a deep analysis of relational capital. Moreover, the CAOS model can be helpful to observe the SC's innovation.
From a theoretical point of view, the research contributes to gender studies, identifying critical, innovative elements that similar women start-ups could implement. From a managerial perspective, findings could increase the firms' competitiveness in the current crisis period and reduce gender inequality.
The application of a single case study could represent a research's limit. Thus, in the future, the authors aim at replicating the analysis considering a more comprehensive sample.
Fostering Participation in Gender Budgeting: A proposal for an online system to enhance citizens' engagement in gender-responsive budgeting
Authors: Mattei Giorgia , Santolamazza Valentina , Elia Beatrice 
Published: April 2022

A controversial issue in the public management literature is the role attributed to women. Analyzing the existing literature, few works have been written about how the presence of women is valued in the public sector. From this analysis, several discriminatory elements are still present, and gender equality seems to be far away. However, this objective must continue to be pursued, also considering the relevance given to the gender equality issue by the United Nations in the Sustainable Development Goals. To achieve this goal, it is necessary to implement political, economic and societal legislation, programs and policies to minimize the differences between men and women. In this perspective, Gender Budgeting (GB) could be an interesting field of research. It consists of a systematic review about how women benefit from public sector expenditures, an adjustment of budgets to ensure equality of access to public sector expenditures, enhancing productive capacity and meeting social needs. However, GB could be adopted differently and could produce several results. In particular, the implementation of GB as a participatory tool is still nowadays a challenge and could be fascinating to analyze, considering the various benefits that a participatory approach could imply. One of the main reasons for the lack of direct citizens involvement in GB is that it was initially developed from a macro-perspective at the national budget. On the other hand, other participatory tools, such as the participatory budget, originate at the local level. Therefore, examining the existing literature and focusing on two different processes, but with some overlapping characteristics elements, namely participatory budgeting and gender budgeting, the present research aims to create a participatory GB framework, investigating the insertion of a participatory perspective in the process, specifically women’s engagement, not neglecting the relevance of digitalization to this end.
Antibiotic-Associated Diarrhea in Children Caused by Clostridium Difficile Infection: Clinical Features, Diagnosis and Treatment
Authors: Романова О.Н. , Довнар-Запольская О.Н. , Преображенская О.А. , Матуш Л.И. , Сергей Ж.С. , Манкевич Р.Н. , Лагир Г.М. , Кастюкевич Л.И. , Коломиец Н.Д. 
Published: April 2022

В статье представлен обзор современных данных об антибиотикоассоциированной диарее, обусловленной Clostridium difficile, у детей. Описаны типы антибиотикоассоциированной диареи, обусловленной Clostridium difficile, у детей. Приведены результаты зарубежных исследований по диагностике, лечению Clostridium difficile-инфекции в детском возрасте.
The article presents an overview of current data on antibiotic-associated diarrhea caused by Clostridium difficile in children. The types of antibiotic-associated diarrhea caused by Clostridium difficile in children are described. The results of foreign studies on the diagnosis and treatment of Clostridium difficile infection in childhood are presented.
Malariogenic Situation in Minsk. Endemic Territories for Malaria in the Republic of Belarus
Authors: Яковлев-Малых Н.Н. , Батуревич Л.В. , Шевякова Е.В. , Кокарева М.В. , Сушко Г.В. 
Published: April 2022

Изменение климата и различные природные аномалии увеличили ареал обитания комаров, особенно рода Anohpeles, что в итоге привело к распространению трансмиссивных заболеваний, таких как малярия, за пределы типичных для нее территорий. Растущая глобализация торговли, путешествий и миграции населения способствуют широкому распространению малярии во всем мире. Несмотря на то, что Беларусь не является основной эндемичной зоной по малярии, отмечается увеличение случаев привозной инфекции в нашу страну.
Climate change and various natural anomalies have led to the expansion of the habitat of mosquitoes, especially the genus Anohpeles, which ultimately led to the spread of vector-borne diseases, such as malaria, beyond its typical territories. The growing globalization of trade, travel and migration is contributing to the widespread malaria throughout the world. Despite the fact that Belarus is not the main endemic area for malaria, there is an increase in the number of imported infections in our country.