bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive analysis to long non-coding RNA-mediated high expression of GNG5 correlates with prognosis and tumor immune infiltration of colon carcinoma
Authors: Zhao Bo , Wang Han , Tang Weizhong 
Published: July 2022

Abstract
Background: Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer deaths , and prognosis is poor and the majority of patients are diagnosed with locally advanced or metastatic disease.Increasing evidence suggests GNG5 play key roles in several types of human cancer.Methods: The key gating mechanisms in colorecal carcinomal are unclear. In this study, Pan-cancer analyses have been performed for GNG5’s expressionon and prognosis using The Cancer Genome Atlas (TCGA) and The Genotype-Tissue Expression (GTEx) data and found that GNG5 might be activated oncogenes in CRC.Results: Noncoding RNAs (ncRNAs) play increasingly appreciated gene-regulatory roles and long noncoding RNAs (lncRNAs) contributing to GNG5 overexpression were identified by a combination in silico computational analyses, we determine candidate regulators controlling colon carcinoma survival analysis and correlation analysis.Finally, the SNHG4/DRAIC-let-7c-5p axis was identifiedas the most potential upstream lncRNA-related pathway of GNG5 in CRC.Conclusion: GNG5 level was significantly positively correlated with tumor immune cell infiltration, immune cell biomarkers and immune checkpoint expression.Collectively, our findings elucidated that lncRNAs-mediated downregulation of GNG5 correlated with better prognosis and tumor immune infiltration in CRC.
NMR Lineshape Analysis: Analytical Solution of Multi-State Chemical Exchange with Applications to Kinetics of Host-Guest Systems
Authors: Březina Václav , Hanyková Lenka , Velychkivska Nadiia , Hill Jonathan P. , Labuta Jan 
Published: July 2022

Abstract
Nuclear magnetic resonance (NMR) lineshape analysis is a powerful tool for the study of chemical kinetics. Here we provide techniques for analysis of the relationship between experimentally observed spin kinetics and corresponding chemical kinetics. The advantages of using analytical solutions for two-, three- or generally N-state exchange lineshapes (without J-coupling) over the widely used numerical calculation for NMR spectral fitting are demonstrated. Several aspects of exchange kinetics including the generalization of coalescence conditions in two-state exchange, the possibility of multiple processes between two states and differences between equilibrium and steady-state modes are discussed. ‘Reduced equivalent schemes’ are introduced for spin kinetics containing fast-exchanging states, effectively reducing the number of exchanging states. The theoretical results have been used to analyze a host-guest system containing an oxoporphyrinogen complexed with camphorsulfonic acid and several other literature examples, including isomerization, protein kinetics, or enzymatic reactions. The theoretical treatment and experimental examples present an expansion of the systematic approach to rigorous analyses of systems with rich chemical kinetics through NMR lineshape analysis.
Comparing the performance of several tool coatings in turning of commercially pure titanium grade 4
Authors: Lemes Carlos Vinicius , Diniz Anselmo Eduardo , Saciotto Victor Rossi 
Published: July 2022

Abstract
The increasing use of titanium and its alloys in the manufacture of implants results from the simultaneous presence of excellent biocompatibility, relatively low density, high mechanical properties and corrosion resistance. Unlike the excellent application characteristics, titanium is classified as a difficult-to-machine material. Therefore, one constant challenge for implant manufacturers is to correctly choose turning tools for each application. This work aims to compare the useful life of the uncoated insert with other three types of coatings on carbide tools, titanium aluminium nitride (TiAlN), aluminum chromium nitride (AlCrN) and titanium nitride / titanium carbonitride multilayer coating (TiN + TiCN). Turning experiments were performed using grade 4 commercially pure titanium (typically used in dental implants), testing two cutting speeds for each tool used. The tests were carried out in a CNC rotary head lathe, using cutting fluid in abundance. The results showed that the uncoated insert achieved the shortest life due to its worst properties (lower surface hardness, higher friction coefficient and lower maximum working temperature), even with its supposedly higher chemical stability with titanium. On the other hand, the tool with the TiN + TiCN multilayer coating obtained the longest tool life among the four tested inserts. This occurred because this is an insert with low coefficient of friction and with multilayer structure coating, what increases its resistance against the wear mechanism that occurred predominantly in this application, which was attrition. Even with the increased cutting speed, this coating also achieved the best result.
Right-sided Weakness in a Rwandan Patient with Unrepaired Tetralogy of Fallot
Authors: Tshilombo Sylvain , Bilugan Romeo , Feeney Amanda , Im Jonathan , Kuntz Heather M , Gandhi Kavita , Barcega Besh , Babane Jean Felix , Ndebwanimana Vincent , Guptill Mindi 
Published: July 2022

Abstract
BackgroundTetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease encountered in pediatrics. Long-term survival after surgical repair has improved; however, reported mortality rates in unrepaired TOF are significant. Associated complications include neurological sequelae, most frequently brain abscess and stroke. In countries without early intervention for congenital heart disease including TOF, delayed presentations and complications require recognition by healthcare workers. Case presentationA 22 year old male with a history of unrepaired TOF presented to Rwanda’s tertiary university hospital, University Teaching Hospital of Kigali (CHUK) with acute right-sided hemiparesis. Diagnostic imaging identified a left-sided brain lesion consistent with brain abscess and cardiac mass concerning for an endocardial vegetation. He was managed with intravenous antibiotics, but subsequently died due to complications of septicemia. ConclusionIn countries where surgical repair of TOF is not available, early recognition and medical management are key in temporizing the development of devastating sequelae. Describing the prevalence of CHD in Rwanda is urgent, requiring further research by which effective prevention and treatment strategies can be developed.
Dust events affect the occurrence of influenza: A case-crossover study in an arid city of China
Authors: Zhang Ling , Li Sheng , Wang Bo , Liu Ce , He Li , Shan XiaoBin , Zhang Kai , Luo Bin 
Published: July 2022

Abstract
Background
Air aerosol is believed to be an important pathway for infectious disease transmission like COVID-19 as well as influenza. Therefore, we hypothesized that there might be a strong association between dust events and influenza, especially in semi-arid areas. This study aims to explore the effects of ambient particulate matter (PM) and dust events on laboratory-confirmed influenza cases in a semi-arid city.
Methods
A descriptive analysis of daily laboratory-confirmed influenza (influenza) cases, PM (PM10 and PM2.5), meteorological parameters and dust events were conducted from 2014 to 2019 in Lanzhou, China. The Case-crossover design combined with conditional Poisson regression models was used to estimate the lagging effects of PM and dust events on influenza. In addition, a hierarchical model was used to quantitatively evaluate the interactive effect of PM with ambient temperature and absolute humidity on influenza.
Results
We found that PM and dust events had a significant effect on influenza. The effects of PM10 and PM2.5 on influenza became stronger as the cumulative lag days increased, the greatest estimated relative risks (RRs) were 1.018 (1.011,1.024) and 1.06 1(1.034,1.087), respectively. Compared with the non-dust days, the effects of dust events with duration ≥ 1 day and with duration ≥ 2 days on influenza were the strongest at lag0 day, with the estimated RRs of 1.245 (95% CI: 1.061–1.463) and 1.483 (95% CI: 1.232–1.784), respectively. Subgroup analysis showed that pre-school children and school-aged children were more sensitive to PM and dust events exposure. Besides, we also found the low humidity and temperature had an interaction with PM, which could aggravate the risk of influenza.
Conclusions
Ambient PM and dust events exposure may increase the risk of laboratory-confirmed influenza, and the risk of laboratory-confirmed influenza increased with the dust events duration. These findings will provide additional epidemiological evidence for future influenza prevention and environmental protection.
Primary lung follicular dendritic cell sarcoma with rare paraneoplastic pemphigus：a case report
Authors: Li Shi-Hao , Dong Bo , Wu Chun-Li , Li Zi-Hao , Qi Yu 
Published: July 2022

Abstract
Background:follicular dendritic cell sarcoma is a rare soft tissue tumor. The incidence is even lower when the lung is the primary site and combined paraneoplastic pemphigus. The purpose of this report is to present the clinicopathological features of this neoplasm in a 29-year-old man. In our case, this tumor caused the patient to develop a paraneoplastic syndrome as well as systemic symptoms. Although local excision of the primary tumor is the treatment of choice, patient required long-term administration of hormones and immunosuppressants. This case provides a new understanding of FDCS with paraneoplastic syndrome.Case presentation:A 29-year-old man was admitted to our hospital with “intermittent cough and sputum for more than 8 months, oral mucosal erosion for 6 months”. The patient had systemic symptoms, including coughing, genital and eye corneal ulcer, photophobia, decreased vision, multiple oral pseudomembranes , local chickenpox and multiple red papules all over the body. The patient underwent thoracoscopic lobectomy and regional lymphadenectomy and pathological biopsy of oral pseudomembranes was performed. Histopathological findings revealed Primary lung mucosal cell sarcoma with paraneoplastic pemphigus, and postoperatively, patient required long-term administration of hormones and immunosuppressants. Conclusion: Follicular dendritic cell sarcoma (FDCS) is a rare tumor associated with paraneoplastic pemphigus, which derived from follicular dendritic cells. Paraneoplastic pemphigus (PNP) is always associated with neoplasm, including gastric adenocarcinoma and lung cancer. the vast majority of FDCS occurs in lymph nodes, so extranodal FDCS cases remain challenging to diagnose, particularly when it occurs in an uncommon site or the histopathologic morphology is atypical. This article emphasizes the rarity of lung extranodal FDCS, and increases awareness of FDCS with paraneoplastic syndromes.
Sample Reduction Algorithm Based on Classification Contribution
Authors: Chai Zheng , Li Yanying 
Published: July 2022

Abstract
Aiming at the disadvantages of exponential growth of time required by KNN algorithm on data sets containing a large number of samples and low classification performance, this paper proposes a sample reduction method based on classification contribution ranking (SRCCR), which not only greatly reduces the storage demand and execution time, but also significantly improves the classification effect of KNN algorithm. Firstly, SRCCR denoises the initial training set, and expands the smooth decision boundary to a certain extent by removing the noise points in the data set; Secondly, the denoised samples are sorted in ascending order based on the classification contribution strategy. The lower the score, the closer the sample is to the class boundary, and the higher the score, the closer it is to the center of the same kind of samples; Finally, the selection process based on local set is used to select a certain representative boundary samples and a small number of central samples to form the final subset. Although the boundary samples contribute the most to the classification accuracy, appropriate retention of central samples can greatly improve the classification effect. In order to verify the effectiveness of the proposed method, we conduct comparative experiments on 24 real data sets from UCI and KEEL databases. Compared with several classical instance selection algorithms, the proposed SRCCR algorithm has certain advantages in accuracy and simplification rate. The results on the two-dimensional data set `Banana' show that SRCCR algorithm not only selects more representative boundary points and center points, but also retains the distribution of the original data set to a great extent.
Dental caries prevalence status in Saudi Arabia and neighboring eastern countries in the last decade – a review
Authors: Souror Yasser , Gharote Harshkant 
Published: July 2022

Abstract
The global prevalence of dental caries and decayed, missing and filled teeth (dmft) is variable in developed and developing countries. Reviews show that dental caries is also adversely affecting the oral health of children in Arab countries. The present review was planned for the data published from 2011 to 2021 to know the current status of the caries prevalence and dmft among children. The review showed an overall prevalence rate of 65.24% in a total of 15319 children with mean dmft score of 3.81 ± 2.97. Four prevalence studies showed average dmft of 5.21 ± 4.01 and 5.29 ± 4.09 for males (988) and females (1060) respectively. The mean dental caries prevalence for the last decade was found to be found decreased compared to the previous two decades but there is no variation in the prevalence rate.
Inhibitory effect of anti-Scg3 on corneal neovascularization: A preliminary study
Authors: Jin He , Yang Binbin , Jiang Dongdong , Ding Zhixiang , Xiong Yu , Zeng Xinsheng 
Published: July 2022

Abstract
Background
Corneal neovascularization (CNV) is an important disease that causes blindness. Scg3 has emerged as a new influencing factor of neovascularization. This study analyzed the effect of Secretogranin III (Scg3) antibody treatment on rabbit corneal neovascularization and explore its inhibitory effect on corneal neovascularization.
Methods
Human umbilical vein endothelial cells (HUVECs) were treated with Scg3 and anti-Scg3. Cell proliferation, wound healing migration and tube formation assays were performed. Healthy adult New Zealand rabbits were randomly selected to be alkali burned and establish the corneal neovascularization (CNV) model. The rabbits were randomly divided into 3 groups (a high concentration group, low concentration group and control group). Different doses of anti-Scg3 and PBS were administered to the rabbits. Clinical examinations, immunostaining, quantitative real-time polymerase chain reaction (qPCR) and western blotting analyses were performed postoperatively.
Results
In the in vitro study, the Scg3 antibody mixture inhibited Scg3-induced endothelial cell proliferation and angiogenesis. In the in vivo study, significant CNV was observed in the control group. Confocal microscopy also revealed considerable active neovascularization in the control group. There was no obvious CNV growth in the high concentration group. Additionally, CD31, LYVE1 and CD45 expression was significantly inhibited after treatment with a high concentration of Scg3 antibody. The qPCR and western blotting analyses revealed that the levels of ERK in the low concentration group and high concentration group were higher than those in the control group at 7 days and 14 days. The levels of VEGF in the control group were significantly increased compared with those in the high concentration group. In all three groups, the levels of Akt were not significantly different at any time point.
Conclusion
The expression of Scg3 could affect the growth of HUVECs in vitro. Treatment with a high concentration (0.5 µg/mL) of Scg3 antibody reduced the inflammatory response and inhibited the growth of corneal neovascularization after corneal alkali burn injury in rabbits. The MEK/ERK pathway might play an important role in the inhibitory effect of anti-Scg3.
Beyond challenges and enrichment: a qualitative account of cross-cultural experiences of nursing ethnic minority patients in Norway
Authors: Alkhaled Tariq , Rohde Gudrun , Lie Birgit , Johannessen Berit 
Published: July 2022

Abstract
Background: Substantial mass migrations to the Scandinavian countries have made them heterogeneous and multicultural societies. Migration has also influenced the workforce, especially the healthcare system that has had to accommodate a culturally diverse population. This qualitative study aimed to explore nurses’ experiences in caring for ethnic minority patients.Methods: Focus group interviews with a total of 21 nurses were conducted. Thematic analysis was performed on the transcribed and translated interviews.Results: The finding of this study revealed three major themes: communicational challenges, cultural challenges, and perks and perils of cross-cultural care.Conclusions: Caring for culturally diverse patients offers both challenges and opportunities to enhance cultural competence and cultural sensitivity among nurses. Various culturally divergent needs of patients such as family visits, food preferences, expression of pain, and gender sensitivity are interlinked and depend on effective communication during encounters with nurses and the healthcare system at large.
Does Nursing Home Health Information Technology Adoption Improve Financial Performance? A Longitudinal Study
Authors: Dayama Neeraj , Felix Holly , Pradhan Rohit , Morris Michael , Karim Saleema 
Published: July 2022

Abstract
Purpose:
The purpose of this study was to examine the longitudinal impact of nursing home Health Information Technology (HIT) adoption on their financial performance. Although nursing homes are an important part of the US healthcare system providing care to the sick and fragile elderly, they were not included in the HITECH incentives for HIT adoption, unlike other hospitals and physicians. As HIT systems are expensive, nursing homes often face uncertainty whether the investment is justifiable.
Methods:
To examine this relationship, we merged existing data from five sources between 2009–2013–Health Information and Management Systems Society, LTCFocus, Online Survey Certification and Reporting/Certification and Survey Provider Enhanced Reporting, Area Health Resource Files, and Medicare Cost Reports.
Results:
We found that nursing homes with higher HIT adoption had 2 percentage points higher operating margin and 7 percentage points lower operating cost per resident day. nursing homes that adopted HIT applications improved their financial performance mainly via reduced operating costs.
Conclusions:
Improved practice efficiency, reduced paperwork, reduced redundant tests, better coordination of care, and reduced medical errors due to HIT may play a role in reducing operating costs. From policy standpoint, our study indicates that by increasing financial performance, HIT adoption may help nursing homes offset efforts to reduce federal and state healthcare spending and increasing costs in response to the COVID-19 pandemic. For nursing home administrators, our findings suggest a potential business case—there may be long-term financial returns for the initial financial burden of HIT implementation.
Association between albumin or prealbumin levels at different stages and prognosis in severe acute pancreatitis: a 5-year retrospective study
Authors: Ni Tongtian , Wen Yi , Wang Yihui , Jiang Weisong , Sheng Huiqiu , Chen Erzhen , Mao Enqiang , Lan Zhixin , Huang Yaguo , Zhou Yuhua 
Published: July 2022

Abstract
Severe acute pancreatitis (SAP) is a common abdominal disorder contributing to high mortality and open laparotomy rates. The role of exogenous infused albumin in fluid resuscitation or continuous therapy has always been an unanswered question. In early stage after onset, SAP patients with higher serum albumin or prealbumin show a better prognosis. In this study, we tried to disclose the linkage between albumin/prealbumin and SAP prognosis and establish a new goal-directed therapy involving albumin and prealbumin. Pearson’s chi-squared test and the Mann–Whitney U test were used to compare the descriptive data between surviving and non-surviving patients. Three days, 4–7 days, 8–14 days and 15–28 days after SAP onset were defined as stages 1 to 4. The average concentrations of albumin and prealbumin were calculated, and receiver operating characteristic (ROC) curves were drawn to screen out the best cutoff values associated with poor prognostic outcomes, including laparotomy and failure to survive. Kaplan-Meier survival curves and log-rank tests were used to validate the effect of the cut-off values. A total of 199 admitted patients were enrolled in this study. According to the analysis of the ROC curve, the serum albumin value should be raised to 35, 37, 40 and 42 g/L in the 1–4 stage after onset. Serum prealbumin values should be raised to 108, 180, and 181 g/L in stages 2–4 after onset. The validity of the above data was confirmed by Kaplan-Meier survival curves. Serum albumin and prealbumin levels in the early stage of SAP are significantly relevant to prognosis. Albumin should be infused from the fluid resuscitation stage to continuous therapy in order to reach the targets mentioned above. The increase in prealbumin depends on the early initiation of enteral nutrition and this also helps to ameliorate the prognosis.
The role of artificial neural networks in prediction of severe acute pancreatitis associated acute respiratory distress syndrome
Authors: Zou Kang , Ren Wensen , Huang Shu , Jiang Jiao , Xu Huan , Xia Huifang , Zeng Xinyi , Zhang Han , Peng Yan , Lü Muhan , Tang Xiaowei 
Published: July 2022

Abstract
Background: Acute respiratory distress syndrome (ARDS) is a serious and common complication of severe acute pancreatitis (SAP), and the early identification and intervention of ARDS are particularly important. This study aimed to construct predictive models for ARDS using early indicators of inpatients. Methods: The 214 SAP patients included were randomly divided into training set and test set, and the back propagation artificial neural networks (BP ANNs) and logistic regression (LR) models were trained by the training set, and then the performance of the two models was examined by the test set. Results: The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), accuracy and area under receiver operating characteristic curves (AUC) value of BP ANNs were 68.0%, 87.5%, 77.3%, 81.4%, 80.0%, 0.853 ± 0.054 (95%CI: 0.749-0.958). The sensitivity, specificity, PPV, NPV, accuracy and AUC value of logistic regression were 48.7%, 85.3%, 65.5%, 74.4%, 72.0%, 0.799 ± 0.045 (95%CI: 0.710-0.888). There were no significant differences between the BP ANNs and LR models in these parameters. Conclusion: Compared to the LR model, the BP ANNs model showed only a mild improvement in predictive performance in our study without significant differences. However, we still believe BP ANNs models have a bright future in clinical outcome prediction.