bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autistic traits heighten sensitivity to rejection‐induced social pain
Authors: Lin Xinxin , Zhuo Shiwei , Liu Zhouan , Fan Junsong , Peng Weiwei 
Published: August 2022

AbstractAutistic traits—subclinical forms of characteristics associated with autism spectrum disorders—are associated with poor social interactions and high risks for mental health disorders. We hypothesized that altered sensitivity to social rejection is an important contributor to psychological distress observed among individuals with high autistic traits. Experiment 1 adopted a social‐judgment task and compared behavioral and neural activity in response to social rejection between participants exhibiting either high or low autistic traits (HAT and LAT, respectively). Rejection‐induced hurt feelings, P3 amplitudes, and θ‐oscillation magnitudes were greater in the HAT group than in the LAT group. Mediation analysis indicated that autistic traits heighten rejection‐induced social pain through increasing frontal‐midline θ‐oscillations. Responses to nonsocial feedback in the age‐judgment task were comparable, confirming that the between‐group differences were specific to social negative feedback. Experiment 2 assessed the association between autistic traits, rejection sensitivity, and psychological distress among randomly recruited participants. Results showed that autistic traits affected depressive/anxious symptomatology partially through heightened rejection sensitivity. Therefore, autistic traits heighten sensitivity to rejection‐induced social pain that leads to psychological distress. This finding will help facilitate the development of strategies for coping with social pain and improving mental health for individuals with high autistic traits.
Identification of fusion transcripts in sarcoma from archival formalin‐fixed paraffin‐embedded tissues: A next‐generation sequencing approach
Authors: Fujii Tomomi , Takeda Maiko , Uchiyama Tomoko , Nitta Yuji , Maebou Katsuya , Terada Chiyoko , Okada Fumi , Matsuoka Minami , Sugimoto Sumire , Sasaki Shoh , Morita Kohei , Itami Hiroe , Miyake Makito , Takeda Masayuki , Sawabata Noriyoshi , Fujimoto Kiyohide , Ohbayashi Chiho 
Published: August 2022

AbstractMost sarcomas are highly aggressive, and cause necrosis and hemorrhage. The diagnosis of sarcoma is challenging because of the lack of specificity of immunohistochemical staining; however, molecular biological approaches, such as genetic mutation, chromosomal translocation, and gene amplification, are promising. In this study, we extracted RNA from formalin‐fixed paraffin‐embedded (FFPE) tissue derived from surgically resected specimens of sarcoma stored for various periods and performed next‐generation sequencing (NGS) analysis by MiniSeq using the Archer Fusion‐Plex Sarcoma Panel. RNA was extracted from 63 FFPE tissue samples, and the degree of RNA degradation was assessed. The number of reads and fragment lengths were evaluated by NGS analysis. RNA extraction and cDNA synthesis were successful in 56 cases and library preparation was possible. Fusion genes were detected in 16 of 63 archived FFPE tissue samples in this study. However, in 18 cases, fragmentation was strong, and high‐quality libraries could not be obtained. Nevertheless, comprehensive analysis of fusion genes with high sequence specificity by NGS can be a powerful alternative to reverse transcription‐polymerase chain reaction and fluorescence in situ hybridization methods.
Reduction of anticipatory brain activity in anxious people and regulatory effect of response‐related feedback
Authors: Mussini Elena , Di Russo Francesco 
Published: August 2022

AbstractElevated anxiety levels degrade task performance, likely because of cognitive function reduction in the frontoparietal brain network. This study aimed to test whether anxiety could impact the frontal cortex anticipatory brain functions and to investigate the possible beneficial effect of response‐related feedback on task performance. The electroencephalographic activity was recorded while participants performed two Go/No‐go tasks: one with response‐related feedback on errors (feedback task) and one task without feedback (standard task). We first tested whether anxiety levels could be associated with pre‐stimulus ERP components such as the prefrontal negativity (pN), linked with top‐down attentional control, and the Bereitschaftspotential (BP), related to motor preparation. Then, we assessed whether feedback could affect anxious people's brain preparation, reducing the state of uncertainty and improving performance. Results showed that the pN was almost absent and the BP was lower during a standard task in the high anxiety than in the low anxiety group. In the feedback task, these components increased in the high anxious, becoming comparable to the low anxious. Behavioral results showed that false alarms in the high anxiety group were larger than in the low anxiety group during the standard task but became comparable in the feedback task. Similarly, response time in the high anxiety group was slower in the standard task than in the feedback task, and high anxious people were faster in the feedback task than in the standard one. This study contributes to clarifying neural correlates of anxiety, showing brain activity reductions related to action preparation in frontal areas. In addition, response‐related feedback tasks could be used to normalize task performance in high anxious people.
Using Saturated Count Models for User-Friendly Synthesis of Large Confidential Administrative Databases
Authors: Jackson James , Mitra Robin , Francis Brian , Dove Iain 
Published: August 2022

AbstractOver the past three decades, synthetic data methods for statistical disclosure control have continually evolved, but mainly within the domain of survey data sets. There are certain characteristics of administrative databases, such as their size, which present challenges from a synthesis perspective and require special attention. This paper, through the fitting of saturated count models, presents a synthesis method that is suitable for administrative databases. It is tuned by two parameters, σ and α. The method allows large categorical data sets to be synthesized quickly and allows risk and utility metrics to be satisfied a priori, that is, prior to synthetic data generation. The paper explores how the flexibility afforded by two-parameter count models (the negative binomial and Poisson-inverse Gaussian) can be utilised to protect respondents'—especially uniques'—privacy in synthetic data. Finally, an empirical example is carried out through the synthesis of a database which can be viewed as a good substitute to the English School Census.
Statistical Integration of Heterogeneous Omics Data: Probabilistic Two-Way Partial Least Squares (PO2PLS)
Authors: el Bouhaddani Said , Uh Hae-Won , Jongbloed Geurt , Houwing-Duistermaat Jeanine 
Published: August 2022

AbstractThe availability of multi-omics data has revolutionized the life sciences by creating avenues for integrated system-level approaches. Data integration links the information across datasets to better understand the underlying biological processes. However, high dimensionality, correlations and heterogeneity pose statistical and computational challenges. We propose a general framework, probabilistic two-way partial least squares (PO2PLS), that addresses these challenges. PO2PLS models the relationship between two datasets using joint and data-specific latent variables. For maximum likelihood estimation of the parameters, we propose a novel fast EM algorithm and show that the estimator is asymptotically normally distributed. A global test for the relationship between two datasets is proposed, specifically addressing the high dimensionality, and its asymptotic distribution is derived. Notably, several existing data integration methods are special cases of PO2PLS. Via extensive simulations, we show that PO2PLS performs better than alternatives in feature selection and prediction performance. In addition, the asymptotic distribution appears to hold when the sample size is sufficiently large. We illustrate PO2PLS with two examples from commonly used study designs: a large population cohort and a small case–control study. Besides recovering known relationships, PO2PLS also identified novel findings. The methods are implemented in our R-package PO2PLS.
Investigating the Association of a Sensitive Attribute with a Random Variable Using the Christofides Generalised Randomised Response Design and Bayesian Methods
Authors: Lee Shen-Ming , Le Truong-Nhat , Tran Phuoc-Loc , Li Chin-Shang 
Published: August 2022

AbstractIn empirical studies involving sensitive topics, in addition to the problem of estimating the population proportion with a sensitive characteristic, a question arises as to whether or not there is heterogeneity in the distribution of an auxiliary random variable representing the information of subjects collected from a sensitive group and a non-sensitive group. That is, it is of interest to investigate the influence of sensitive attribute on the auxiliary random variable of interest. Finite mixture models are utilised to evaluate the association. A proposed Bayesian method through data augmentation and Markov chain Monte Carlo is applied to estimate unknown parameters of interest. Deviance information criterion and marginal likelihood are employed to select a suitable model to describe the association of the sensitive characteristic with the auxiliary random variable. Simulation and real data studies are conducted to assess the performance of and illustrate applications of the proposed methodology.
Central coordination, regional competition, and local protectionism: Social decentralisation in China's long‐term care reform
Authors: Chan Wing‐kit , Shi Shih‐Jiunn 
Published: August 2022

AbstractChanging central‐local relations shape social policymaking and implementation in China. We develop a social decentralisation perspective to explore various inter‐governmental dimensions in the formulation and implementation of social policy, based on experimentation in the provision of long‐term care insurance starting in 2016. As localities devised new programmes, they initiated innovations in the context of central‐local relations with Chinese characteristics. Three areas are duly examined: central coordination, regional competition, and regional protectionism. Intending to develop a national programme but reluctant to provide support through tax revenues, central government coordination reflects in both the central government's selection of cities across regions and allowing room for local diversity—some with deliberate experimental purposes—a feature which generated regional competition between pilot cities. Furthermore, as additional contributions for pilot programmes in some cities are waived, this process entails resource extraction from existing funding surpluses, unleashing local protectionism contrary to central government interests. Our analysis finds that the central government faces a dilemma: either meeting new social needs at the cost of increased regional inequality or balancing social policy developments across regions by enacting necessary programmatic reforms that sap central resources and weaken the central government's coordination capacity. These dynamics of social decentralisation will shape the future development and impact of Chinese social policy.
Does “green gold” breed bloody violence? The effect of export shocks on criminal violence in Mexico
Authors: Yoo Heesun 
Published: August 2022

AbstractObjectiveDo positive export shocks fuel or dampen criminal violence? The predation mechanism predicts that increasing export revenue generates a larger contested resource, and it prompts more violence by increasing the expected benefit of expropriation. The opportunity cost mechanism instead argues that an increase in exports may deter individuals from engaging in criminal activity, as it drives up labor demand and wages in the formal labor market. I test these competing claims using a case of the Mexican avocado industry.MethodI test these claims by estimating a causal effect of avocado production on criminal violence in Mexico. I further address the endogeneity issue with an instrumental variable approach, exploiting exogenous variations in climatic conditions that affect agricultural crop yields.ResultMoving from the lowest to the highest level of monthly avocado production, this positive change in avocado production reduces the homicide rate by 0.65 per hundred thousand relative to the average monthly homicide rate of 2.02.ConclusionThis finding suggests that the opportunity cost effect is largely at play in the avocado‐growing Mexican states, showing a new context of theory application. Limitations and future research avenues are discussed.
A multicenter retrospective evaluation of the prevalence of known and presumed hereditary eye diseases in Lagotto Romagnolo dog breed within a referral population in Italy (2012–2020)
Authors: Crasta Manuela , Arteaga Kevin , Barachetti Laura , Guandalini Adolfo 
Published: August 2022

AbstractObjectiveTo describe the ophthalmological findings of Lagotto Romagnolo dog breed and to report the prevalence of Known and Presumed Hereditary Eye Diseases (KP‐HED).Animals StudiedTwo hundred sixteen dogs were examined and included in this retrospective study.ProceduresMedical records of Lagotto Romagnolo dogs between 2012 and 2020 were included. Data about the ocular status were collected through ocular screening examinations (OSE) or clinical ophthalmic examinations (COE). The prevalence of each KP‐HED was expressed as a function of the total number of the KP‐HED in this referral population.ResultsA total of 85 dogs (39.35%) were ophthalmologically healthy, ocular diseases presumably not hereditary were found in 43 dogs (19.91%), and 88 dogs (40.74%) were affected by one KP‐HED. The most common KP‐HEDs diagnosed were cataract (28/88; 31.82%), corneal endothelial dystrophy (17/88; 19.32%), retinal dysplasia (9/88; 10.23%), lens instability (7/88; 7.95%), progressive retinal atrophy (6/88, 6.82%), and keratoconjunctivitis sicca (6/88, 6.82%). Most of dogs with a KP‐HED (77.27%, 68/88) were identified within COE group.ConclusionsTo the authors' knowledge, this is the first report of the prevalence of ocular disease in the Lagotto Romagnolo dog breed within a referral population in Italy. This study suggests a relatively high prevalence of KP‐HED, with a characteristic late‐onset presentation in some diseases. Many of these KP‐HED's, lead to ocular pain and irreversible blindness, for this reason, the authors highlight the importance of aiming for an early diagnosis. Breeder's efforts and breeding programs should be directed at limiting such disorders.
Effectiveness of telehealth versus standard care on health care utilization, health-related quality of life, and well-being in homebound populations: a systematic review protocol
Authors: Pinero de Plaza Maria Alejandra , Beleigoli Alline , Brown Shannon , Bulto Lemma N. , Gebremichael Lemlem G. , Nesbitt Katie , Tieu Matthew , Pearson Vincent , Noonan Sara , McMillan Penelope , Clark Robyn A. , Hines Sonia , Kitson Alison , Champion Stephanie , Dafny Hila , Hendriks Jeroen M. 
Published: August 2022

Abstract

Objective:
The objective of the review is to determine the effectiveness of telehealth versus in-person care on health care utilization, health-related quality of life and well-being in homebound populations.

Introduction:
Globally, an increasing number of people are becoming homebound. These individuals experience high levels of social isolation and deterioration of their well-being. Reports from homebound people and recent publications suggest that this cohort may benefit from accessing telehealth solutions from their homes to treat and prevent serious issues affecting their health and well-being. This review will synthesize the evidence on the effectiveness of telehealth compared to standard care (in-person care) on health care utilization, health-related quality of life, and well-being in homebound populations.

Inclusion criteria:
Studies including people living in community settings, whose daily life is physically limited to the boundary of their homes because of their ongoing health, energy, and psychosocial or socio-functional impairments will be considered for inclusion.

Methods:
This review will consider relevant, peer-reviewed primary experimental and quasi-experimental studies, with no limit on language or date, form: MEDLINE, Embase, PsycINFO, CINAHL, the Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, LILACS, JBI Evidence Synthesis (hand-searched for further studies), and Web of Science. Two independent reviewers will be involved in study selection and data extraction. Eligible studies will be critically appraised for methodological quality using the relevant JBI critical appraisal checklists, and statistical meta-analysis will be done (where possible). Findings will be presented in narrative form.

Systematic review registration number:
PROSPERO CRD42021289578.
Prevalence, clinical features, and outcomes of COVID-19 in persons with cystic fibrosis: a systematic review protocol
Authors: Antony Sherly , Vargese Saritha Susan , Idikula Mercy John , Cherian Carol Sara , Mathew Elsheba , Green Heidi , Fernandez Ritin 
Published: August 2022

ABSTRACT

Objective:
The objective of this review is to determine the incidence and prevalence, clinical features, and outcomes of COVID-19 in persons with cystic fibrosis.

Introduction:
Cystic fibrosis, predominantly a chronic respiratory illness, has long been known to be fatal with concomitant bacterial or viral infections. However, the effects of COVID-19 on this protracted disease need to be understood, especially since the major manifestations affect the respiratory system. Hence, the burden, clinical features, and outcomes of COVID-19 on individuals with cystic fibrosis need to be understood.

Inclusion criteria:
This review will consider studies on persons in all age groups with preexisting cystic fibrosis who are diagnosed with COVID-19 using either a polymerase chain reaction, serology, or point-of-care test for SARS-CoV-2.

Methods:
JBI methodology for systematic reviews of prevalence and incidence will be used for this review. A methodical search for eligible studies in English (as well as available translations) in MEDLINE, Embase, Scopus, and CINAHL, and unpublished literature in Google Scholar, Dissertation Abstracts International, ProQuest Dissertations and Theses, and MedNar will be conducted from the year 2020 onwards. Studies meeting the inclusion criteria will be selected for appraisal and their methodological quality will be assessed by two independent reviewers based on study titles and abstracts, followed by full-text review focusing on sampling and statistical analysis. Data extraction will be accomplished using a standardized tool. If adequate synthesized data are obtained, a meta-analysis will be conducted; otherwise, the findings will be presented in a narrative format, including tables and figures to aid in data presentation where appropriate.

Systematic review registration number:
PROSPERO CRD42021237792
Development of a Novel Welding Technique With Reduced Heat-Input by Employing Double-Pulsed Gas Metal Arc Welding for Aerospace Grade 18% Ni Maraging Steel
Authors: Jose Bibin , Manikandan M. , Arivazhagan N. , Muktinutalapati Nageswara Rao , Madhusudhan Reddy G. 
Published: August 2022

Abstract
Eighteen percent Ni maraging steels are high performance Fe–Ni martensite-based alloys with ultra-high strength and good toughness. They find applications in strategic sectors, joining of thick sections often coming into picture. Welding of thick section involves a longer processing time, more passes, and a higher heat-input. Double-pulsed gas metal arc welding (DP-GMAW) is an emerging welding technique, well suited for joining thick sections. DP-GMAW is capable of controlling the solidification parameters, weld pool geometry, and cooling rate at a reduced heat-input. The major concern regarding the welding of maraging steel is the formation of the reverted austenite (RA) phase in the fusion zone (FZ). The formation of RA deteriorates the mechanical performance of welded joints. The presence of RA can be supressed by the usage of suitable welding techniques and proper post-weld heat treatments (PWHTs). DP-GMAW process was employed to carry out the welding; studies on the joints produced are reported in this research paper. The studies also included the effect of various PWHTs on the metallurgical and mechanical properties of the maraging steel weldments. The research used three distinct PWHTs: direct aging (DA), solutionizing + aging (SA), and homogenizing + solutionizing + aging (HSA). The FZ microstructures under DA and SA conditions show that there is RA at the cell boundaries. However, there was no evidence of RA in FZ following HSA. The energy dispersive spectra (EDS) analysis of the as-welded FZ showed segregation along the grain boundaries (GBs). This led to the premature formation of RA upon subsequent aging. The SA treatments proved inadequate to totally eliminate RA in the microstructure. On the other hand, the HSA treatments were effective in evening out concentration differences and preventing formation of RA. This study demonstrates that DP-GMAW combined with HSA treatment has the best mechanical properties.
A Novel Design of a Multi-Fingered Bionic Hand With Variable Stiffness for Robotic Grasp
Authors: Zang Xizhe , Wang Chao , Zhang Pu , Liu Gangfeng , Zhang Xuehe , Zhao Jie 
Published: August 2022

AbstractThe robotic hand plays an extremely significant role in completing various robotic tasks, especially for a robot to complete different grasping tasks. In this paper, we propose a novel multi-fingered bionic hand with variable stiffness for robotic grasp. First, based on the analysis of the human hand, we design the modular finger with variable stiffness mechanism and the flexible thumb with dual-link independent mechanism. Second, the multi-fingered bionic hand composed of three modular fingers and one flexible thumb is presented, which possesses 14 degrees-of-freedom (DoFs). Then, the parameters of the designed hand are analyzed to obtain the stiffness characteristics and working space. Furthermore, the grasping control method based on position control and force control is proposed for robotic grasp. Finally, a series of experiments are designed to verify the effectiveness of the designed hand and the proposed method. The experimental results show that (1) the designed variable stiffness mechanism can be used to adjust the stiffness of hand fingers, (2) the proposed method can effectively control the grasping force under different stiffness conditions, and (3) the designed hand can successfully grasp different types of objects by various grasping strategies.