bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamical modelling and emission signatures of a candidate dual AGN with precessing radio jets
Authors: Giri Gourab , Dubey Ravi Pratap , Rubinur K , Vaidya Bhargav , Kharb Preeti 
Published: June 2022

ABSTRACT
In this paper, we have modelled the dynamical and emission properties (in the presence of radiative losses and diffusive shock acceleration) of an observed S-shaped radio source (2MASX J12032061+131931) due to a precessing jet. In this regard, we have performed high-resolution 3D magnetohydrodynamic (MHD) simulations of a precessing jet in a galactic environment. We show the appearance of a distinct S-shape with two bright hotspots when the bow shock region weakens over time. The formed morphology is sensitive to the parameter selections. The increased interaction between the helical jet and the ambient medium and the deceleration of the jet due to MHD instabilities also greatly affect the resulting structure. Hence, kinematic models must be corrected for these deceleration effects in order to adequately predict the precession parameters. The synthetic spectral index map shows that the jet side and leading edges possess relatively steeper spectral index values than the jet ridge lines, whereas the hotspots show flat spectral index values. The jets are also found to be highly linearly polarized (up to 76 per cent) and the magnetic field lines, in general, follow the jet locus which is formed due to the jet-ambient medium interaction. Diffusive shocks, in this context, keep the structure active during its course of evolution. Furthermore, we have demonstrated that these galaxies deviate significantly from the ‘equipartition’ approximation leading to a discrepancy in their spectral and dynamical age.
OGLE-2018-BLG-0799Lb: a q ∼ 2.7 × 10−3 planet with Spitzer parallax
Authors: Zang Weicheng , Shvartzvald Yossi , Udalski Andrzej , Yee Jennifer C , Lee Chung-Uk , Sumi Takahiro , Zhang Xiangyu , Yang Hongjing , Mao Shude , Novati Sebastiano Calchi , Gould Andrew , Zhu Wei , Beichman Charles A , Bryden Geoffery , Carey Sean , Gaudi B Scott , Henderson Calen B , Mróz Przemek , Skowron Jan , Poleski Radoslaw , Szymański Michał K , Soszyński Igor , Pietrukowicz Paweł , Kozłowski Szymon , Ulaczyk Krzysztof , Rybicki Krzysztof A , Iwanek Patryk , Wrona Marcin , Albrow Michael D , Chung Sun-Ju , Han Cheongho , Hwang Kyu-Ha , Jung Youn Kil , Ryu Yoon-Hyun , Shin In-Gu , Cha Sang-Mok , Kim Dong-Jin , Kim Hyoun-Woo , Kim Seung-Lee , Lee Dong-Joo , Lee Yongseok , Park Byeong-Gon , Pogge Richard W , Bond Ian A , Abe Fumio , Barry Richard , Bennett David P , Bhattacharya Aparna , Donachie Martin , Fujii Hirosane , Fukui Akihiko , Hirao Yuki , Itow Yoshitaka , Kirikawa Rintaro , Kondo Iona , Koshimoto Naoki , Li Man Cheung Alex , Matsubara Yutaka , Muraki Yasushi , Miyazaki Shota , Ranc Clément , Rattenbury Nicholas J , Satoh Yuki , Shoji Hikaru , Suzuki Daisuke , Tanaka Yuzuru , Tristram Paul J , Yamawaki Tsubasa , Yonehara Atsunori , Bachelet Etienne , Hundertmark Markus P G , Jaimes R Figuera , Maoz Dan , Penny Matthew T , Street Rachel A , Tsapras Yiannis 
Published: June 2022

ABSTRACT
We report the discovery and analysis of a planet in the microlensing event OGLE-2018-BLG-0799. The planetary signal was observed by several ground-based telescopes, and the planet-host mass ratio is q = (2.65 ± 0.16) × 10−3. The ground-based observations yield a constraint on the angular Einstein radius θE, and the microlensing parallax vector $\boldsymbol{{\pi} }_{\rm E}$, is strongly constrained by the Spitzer data. However, the 2019 Spitzer baseline data reveal systematics in the Spitzer photometry, so there is ambiguity in the magnitude of the parallax. In our preferred interpretation, a full Bayesian analysis using a Galactic model indicates that the planetary system is composed of an $M_{\rm planet} = 0.26_{-0.11}^{+0.22}M_{\rm J}$ planet orbiting an $M_{\rm host} = 0.093_{-0.038}^{+0.082}~\mathrm{M}_{\odot }$, at a distance of $D_{\rm L} = 3.71_{-1.70}^{+3.24}$ kpc. An alternate interpretation of the data shifts the localization of the minima along the arc-shaped microlens parallax constraints. This, in turn, yields a more massive host with median mass of $0.13 {\, \mathrm{M}_{\odot }}$ at a distance of 6.3 kpc. This analysis demonstrates the robustness of the osculating circles formalism, but shows that further investigation is needed to assess how systematics affect the specific localization of the microlens parallax vector and, consequently, the inferred physical parameters.
E3 ligase AtAIRP5/GARU regulates drought stress response by stimulating SERINE CARBOXYPEPTIDASE-LIKE1 turnover
Authors: Cho Na Hyun , Woo Og-Geum , Kim Eun Yu , Park Kiyoul , Seo Dong Hye , Yu Seong Gwan , Choi Yoon A , Lee Ji Hee , Lee Jae-Hoon , Kim Woo Taek 
Published: June 2022

Abstract
Ubiquitination is a major mechanism of eukaryotic posttranslational protein turnover that has been implicated in abscisic acid (ABA)-mediated drought stress response. Here, we isolated T-DNA insertion mutant lines in which ABA-insensitive RING protein 5 (AtAIRP5) was suppressed, resulting in hyposensitive ABA-mediated germination compared to wild-type Arabidopsis (Arabidopsis thaliana) plants. A homology search revealed that AtAIRP5 is identical to gibberellin (GA) receptor RING E3 ubiquitin (Ub) ligase (GARU), which downregulates GA signaling by degrading the GA receptor GID1, and thus AtAIRP5 was renamed AtAIRP5/GARU. The atairp5/garu knockout progeny were impaired in ABA-dependent stomatal closure and were markedly more susceptible to drought stress than wild-type plants, indicating a positive role for AtAIRP5/GARU in the ABA-mediated drought stress response. Yeast two-hybrid, pull-down, target ubiquitination, and in vitro and in planta degradation assays identified serine carboxypeptidase-like1 (AtSCPL1), which belongs to the clade 1A AtSCPL family, as a ubiquitinated target protein of AtAIRP5/GARU. atscpl1 single and atairp5/garu-1 atscpl1-2 double mutant plants were more tolerant to drought stress than wild-type plants in an ABA-dependent manner, suggesting that AtSCPL1 is genetically downstream of AtAIRP5/GARU. After drought treatment, the endogenous ABA levels in atscpl1 and atairp5/garu-1 atscpl1-2 mutant leaves were higher than those in wild-type and atairp5/garu leaves. Overall, our results suggest that AtAIRP5/GARU RING E3 Ub ligase functions as a positive regulator of the ABA-mediated drought response by promoting the degradation of AtSCPL1.
Systemic Cytokine Level Differences in Patients with Chronic Musculoskeletal Spinal Pain Compared to Healthy Controls and Its Association with Pain Severity: A Systematic Review
Authors: Canlı Kübra , Billens Amber , Van Oosterwijck Jessica , Meeus Mira , De Meulemeester Kayleigh 
Published: June 2022

Abstract

Objective
Although there has been increasing interest in the role of systemic cytokines in chronic spinal pain (CSP), the evidence on their potential contribution is still unclear. Therefore, the current study systematically reviewed the evidence on systemic cytokine level differences between people with CSP compared to healthy controls (HCs) and the potential associations with pain severity.

Methods
An electronic search was conducted on PubMed, Web of Science and Embase. All included studies were classified as observational studies, exploring the comparison between a CSP group and a HC group, and the association between systemic cytokine levels and pain severity.

Results
Nine articles were included with a total sample of 400 CSP patients suffering from chronic whiplash associated disorder (CWAD) or chronic low back pain (CLBP). In CLBP, moderate evidence was found for elevated tumor necrosis factor (TNF) α, interleukin (IL) 6, IL-1 receptor antagonist (IL-1RA), and soluble TNF receptor (sTNF-R) type 2, for normal interferon (IFN) γ and IL-2 levels, and for reduced IL-10 levels. No association was found between pain severity and these cytokines in CLBP. In CWAD, moderate evidence was found for elevated CRP and evidence for changes in TNF-α was inconclusive. Evidence for the association between pain severity and CRP was limited, and there is probably no association between pain severity and TNF-α with limited evidence in CWAD.

Conclusions
Moderate evidence indicates the presence of systemic inflammation in CSP. Evidence regarding the association between pain severity and systemic cytokines is inconclusive and limited.
The female to male calf sex ratio is associated with the number of services to achieve a calf and parity of lactating dairy cows
Authors: Mendes Andrew J , Murphy Michael R , Casper David P , Erickson Peter S 
Published: June 2022

Abstract
Commercial dairy producers may get frustrated by the lower ratio of female to male calves born because female calves are more valuable than bull calves. Our objective was to determine if parity or stage of lactation at the time of breeding, using conventional semen, influenced the sex of the calf. Data from the University of Illinois and the University of New Hampshire dairy herds were collected and summarized for calf sex, the number of services to achieve a calf and the lactation number when conception of that calf occurred. Logistical regression procedures were used to analyze the dataset via version 9.4 of SAS. The final dataset contained 2,987 calvings, which consisted of 1,406 females and 1,581 males (47.1% and 52.9% for females and males, respectively). The frequency distribution of the number of services to achieve a calf was highest for the first service and progressively declined with increasing services (52.06%, 21.66%, 10.75%, 6.66%, 4.22%, and 4.65% for 1 to 6 services, respectively). The frequency distribution of calvings by lactation number was greatest for first lactation cows becoming pregnant with their second calf and declined with increasing parity (35.49%, 28.22%, 17.01%, 9.61%, 5.02%, 2.51%, 1.14%, 0.70%, and 0.30% for lactation numbers 1 to 9, respectively). Logistic stepwise regression indicated that the number of services to achieve a calf was significant in predicting the ratio of female to male calves. Calculation of odds ratios indicated that as the lactation number increased the likelihood of getting a bull calf decreased. Parity, services, and parity by services interaction were significant for cows having a greater number of parities and cows with a greater number of services yielding more heifer calves. However, an interaction occurred where cows with greater number of services along with greater parities more likely to have a bull calf. These data provide evidence that increasing the number of services to achieve a calf and increasing age of the cow increased the probability of a heifer calf being born. These data indicate that cows with greater parties (lesser cull rate) are more likely to produce heifer calves.
Rose Rosette Disease: A Diagnostic Guide
Authors: Claros Nicolas Aparicio , Shires Madalyn , Mollov Dimitre , Hammond John , Jordan Ramon , Ochoa-Corona Francisco , Olson Jennifer , Ong Kevin , Salamanca Lina Rodriguez 
Published: June 2022

Rose rosette disease (RRD) is a common disease of roses, predominantly in North America. RRD is caused by the rose rosette virus (RRV), an emaravirus transmitted by the eriophyid mite Phyllocoptes fructiphilus Keifer. RRD characteristic symptoms include deformed leaves, abnormal thorns, and witches’ brooms. Roses are important cultivated plants around the world. Most Rosa spp. and cultivated varieties such as climbers, hybrid teas, floribundas, and miniature roses are susceptible to the disease. Rose rosette virus detection relies on molecular assays.
PULSE PRESSURE ASSOCIATED WITH PHYSICAL FUNCTION DECLINE AND FRAILTY SYNDROME PROGRESSION
Authors: Chuang Shao-Yuan , Lin Wen-Ling , Lai Chia-Hung , Chung Ren-Hua , Hsu Chih-Cheng 
Published: June 2022

Objective:
Arterial stiffness and hypertension interacted and related to frailty syndrome. The physical function decline was the dominant component of frailty syndrome. The longitudinal relationships of arterial stiffness and hypertension for physical function decline among elderly population remain ambiguous. We aimed to investigate the associations of arterial stiffness and hypertension for the physical, functional decline in a prospective study.

Design and method:
A total of 3218 adults aged >  = 55 years old from The Healthy Aging Longitudinal Study in Taiwan (HALST) cohort was followed 5 years for evaluating the physical, functional decline, including gait speed, hand grip, the 6-meter walking distance at baseline (2008) and 2nd wave (2013). Artery stiffness were evaluated by the pulse pressure (systolic mines diastolic blood pressure). The physical function decline was defined by the significantly slower gait speed (gait speed because lower more than 0.23 m/sec). Logistic regression was used to evaluate the associations of pulse pressure and hypertension for the slowness of gait speed.

Results:
Baseline pulse pressure was associated the changes of gait speed (beta = -0.1121, p < .0001). The changes of gait speed between baseline and the followed wave for those with PP < 40 mmHg(group-1,n = 196), 40–60 mmHg(group-2, n = 1874), 60–70 mmHg(group-3,n = 656), 70–80 mmHg(group-4,n = 302) and > = 80 mmHg(group-5,n = 190) were 0.04 ± 0.24 m/sec, 0.00 ± 0.23 m/sec, -0.04 ± 0.42 m/sec, -0.05 ± 0.23 m/sec, and -0.07 ± 0.25 m/sec (p-value for trend < .0001), respectively. The proportion of significant decline in gait speed (-0.23m/sec) was 10.20% for group-1, 17.56% for group-2, 22.87% for group-3, 27.48% for group-4 and 33.68% for group-5 (p-value for trend < 0.0001). Compared to those with PP less than 40 mm Hg (group-1), the odds ratio of physical, functional decline was 4.47(95% confidence intervals: 2.57–7.76) for group-5, 3.34(1.97–5.65) for group-4, 2.61(1.59∼4.29) for group-3 and 1.87(1.16∼3.02) for group-2. The associations remain significant in the model adjusted for age and glucose.We also found higher systolic BP (Systolic BP> = 150 mmHg) has significantly risk for physical function decline (OR = 1.32; 95% CI:1.01∼1.73), compare to normal blood pressure or well controlling BP (SBP: 120∼140 mmHg)

Conclusions:
Pulse pressure was associated with physical function decline among elderly population. Blood pressure controlling could delay the progression of physical function decline.
DISENTANGLING THE VARYING ASSOCIATIONS BETWEEN SYSTOLIC BLOOD PRESSURE AND HEALTH OUTCOMES IN THE VERY OLD: AN INDIVIDUAL PATIENT DATA META-ANALYSIS
Authors: Bogaerts Jonathan , Poortvliet Rosalinde , Van Der Klei Veerle , Achterberg Wilco , Blom Jeanet , Teh Ruth , Muru-Lanning Marama , Kerse Ngaire , Rolleston Anna , Jagger Carol , Kingston Andrew , Robinson Louise , Arai Yasu , Shikimoto Ryo , Gussekloo Jacobijn 
Published: June 2022

Objective:
While randomized controlled trials have proven the benefits of blood pressure (BP) lowering in participating octogenarians, population-based observational studies suggest an association between low systolic blood pressure (SBP) and faster overall decline. This study investigates the effects of BP-lowering treatment, a history of cardiovascular diseases (CVD), and cognitive and physical fitness on the associations between SBP and health outcomes in the very old.

Design and method:
Five cohorts from the Towards Understanding Longitudinal International older People Studies (TULIPS) consortium were included in a two-step individual participant data meta-analysis (IPDMA). We pooled hazard ratios (HR) from Cox proportional-hazards models for five-year mortality and estimates of linear mixed models for change in cognitive and functional decline. Models were stratified by BP-lowering treatment, history of CVD, Mini-Mental State examination-scores (MMSE) and grip strength (GS).

Results:
Of all 2480 participants (59.9% females, median 85 years), median baseline SBP was 149 mmHg, 64.3% used BP-lowering drugs and 47.3% had a history of CVD. Overall, higher SBP was associated with lower all-cause mortality (pooled HR 0.91 [95%CI 0.88–0.95] per 10 mmHg). Associations remained irrespective of BP-lowering treatment and history of CVD, but were absent in octogenarians with above-median MMSE and GS. In pooled cohorts, SBP was not associated with cognitive and functional decline.

Conclusions:
While in the very old with low cognitive or physical fitness, a higher SBP was associated with a lower all-cause mortality, this association was not evident in fit octogenarians. SBP was not consistently associated with cognitive and functional decline.
PREDICTING THE PATTERN OF ANATOMICAL LEFT VENTRICULAR HYPERTROPHY USING ELECTROPHYSIOLOGICAL BIOMARKERS FROM THE ECG QRS COMPLEX IN HYPERTENSIVE INDIVIDUALS FROM UK BIOBANK
Authors: Naderi Hafiz , Ramírez Julia , Van Duijvenboden Stefan , Aung Nay , Fung Kenneth , Young William , Petersen Steffen , Munroe Patricia 
Published: June 2022

Objective:
Hypertension has progressive end-organ effects such as left ventricular hypertrophy (LVH), an established independent predictor of cardiovascular morbidity and mortality. Four distinct LVH phenotypes with varying prognostic implications have been described using cardiac magnetic resonance (CMR) LV mass to volume ratio; normal LV, LV remodelling, eccentric LVH and concentric LVH. Current electrocardiogram (ECG) criteria can detect LVH but their ability to differentiate between LVH phenotypes is unclear.

Design and method:
As a preliminary analysis, 5,065 participants in the UK Biobank were categorised into the 4 CMR-defined LVH phenotypes. The 12 lead ECG of each participant was analysed using MATLAB to derive ECG biomarkers known to have an association with LVH (QRS duration, QRS ascending and descending slopes, Q wave, R wave, S wave and QRS wave amplitudes). ANOVA compared differences in ECG biomarkers across LVH phenotypes. Univariate logistic regression was used to test association of each ECG biomarker with the LVH phenotypes. ECG biomarkers with a significant association (P < 0.05) were included in the multinomial logistic regression model.

Results:
In combination, the set of 7 ECG biomarkers detected a difference (P < 2.2e-16) across the LVH phenotypes. Using logistic regression, QRS duration, S wave and QRS waves amplitude were able to differentiate between the 4 LVH phenotypes. With normotensive group as a reference, there was a significant association between S wave amplitude and normal LV (Odds Ratio 1.80, P 1.46e-03), QRS wave amplitude and normal LV (OR 2.23, P 9.01e-05), global QRS duration with eccentric LVH (OR 1.05, P 4.45e-06) and concentric LVH (OR 1.03, P 1.02e-05).

Conclusions:
We identified a set of ECG markers from the QRS complex that can differentiate between the 4 LVH phenotypes, providing support for the ECG to identify subclinical LVH identified using CMR. We are currently extending our analyses to the full 45,000 UK Biobank imaging cohort for validation.
HOME BLOOD PRESSURE MONITORING SCHEDULE: OPTIMAL AND MINIMUM BASED ON 2,122 INDIVIDUAL SUBJECTS’ DATA
Authors: Kyriakoulis Konstantinos , Ntineri Angeliki , Niiranen Teemu , Lindroos Annika , Jula Antti , Schwartz Claire , Kollias Anastasios , Andreadis Emmanuel , McManus Richard , Stergiou George S. 
Published: June 2022

Objective:
Home blood pressure (HBP) monitoring has become a primary method for hypertension diagnosis and management. Most hypertension guidelines suggest HBP monitoring for 3–7 days and exclusion of first day for calculation of the average. This analysis investigated the optimal and minimum schedule for HBP monitoring using a European database.

Design and method:
A retrospective analysis of cross-sectional research data was performed, which involved HBP and 24-hour ambulatory BP (ABP) monitoring in adults collected within the context of clinical studies in Finland, Greece, and UK. Participants with 6–7 HBP monitoring days and at least 12 HBP readings were included. The stability of HBP was assessed by evaluating the average value and variability (SD) of an increasing number of readings. The association of different HBP schedules with awake ABP was also assessed.

Results:
Data from 2,122 participants were analyzed (mean age 53.9 ± 11.3 years, males 53%, treated 34%). A progressive HBP decline was observed in succeeding days, reaching a plateau after day 3. Day 1 average HBP was higher than in the next days by about 2.8/1.4 mmHg (systolic/diastolic, p < 0.001). Similarly, day 1 HBP SD was higher than in the next days. In a 3-day HBP monitoring schedule, the exclusion of day 1 reduced average HBP and SD, with a clinically important HBP decline in 115 participants (5%) and different hypertension diagnosis in 120 (6%). For HBP monitoring schedules including more than 3 days, the exclusion of day 1 had negligible impact. In a 6-day HBP monitoring schedule, the exclusion of day 1 led to clinically important HBP decline in 0.4% of participants and to different hypertension diagnosis in 3%. The 3-day average HBP was strongly correlated with awake ABP (correlation coefficient r = 0.70/0.77 systolic/diastolic, p < 0.05), with little improvement thereafter.

Conclusions:
These data support the recommendation for 7-day HBP monitoring as optimal schedule and 3-day as minimum. Readings of the first day should better be excluded, particularly when the minimum 3-day monitoring is obtained.
ANTIHYPERTENSIVE DRUG TREATMENT IN WHITE-COAT HYPERTENSION: DATA FROM THE PLAQUE HYPERTENSION LIPID-LOWERING ITALIAN STUDY (PHYLLIS)
Authors: Quarti-Trevano Fosca , Seravalle Gino , Dell’Oro Raffaella , Facchetti Rita , Grassi Guido , Mancia Giuseppe 
Published: June 2022

Objective:
No trial-based evidence is available on whether antihypertensive treatment lowers cardiovascular risk in white-coat hypertension (WCH). Protection may be indirectly inferred, however, from the blood pressure (BP) effects of treatment, because in trials outcomes decrease is linearly related to BP reduction. We andomis the effect of antihypertensive treatment on office and out-of-office BP in WCH using data from the Plaque HYpertension Lipid-Lowering Italian Study (PHYLLIS).

Design and method:
Office and ambulatory BP were measured in 470 hypertensive patients andomisat to an ACE-inhibitor or a diuretic alone or combined with a statin before treatment and at yearly intervals during a 3-year follow-up. Patients were divided into two groups according to whether baseline data obtained before andomisation to treatment showed that 1) office and 24-hour mean BP were elevated (75.8% sustained hypertensive, SH) or 2) office BP was elevated but 24-hour BP values were normal (24.2% WCH).

Results:
Antihypertensive drug treatment was associated with an early marked reduction of BP, which persisted virtually unchanged throughout the treatment period and was only slightly and usually not significant different in SH and WCH (-18.9 ± 11.1/-12.7 ± 5.9 mmHg for SBP/DBP in SH and -18 ± 10.4/-12.3 ± 6.2 for SBP/DBP in WCH p = 0.43/p = 0.52). This was not the case, however, for 24-h BP which, fell consistently in SH while showing no change in WCH(-10.7 ± 10.8/1.0 ± 8.3 mmHg for SBP/DBP in SH and -7.4 ± 7.2/0.1 ± 4.8 for SBP/DBP in WCH p < 0.001/p < 0.001). In SH but not in WCH antihypertensive treatment consistently reduced either the higher daytime and the lower nighttime SBP and DBP values during the treatment.

Conclusions:
In WCH antihypertensive treatment can effectively and durably reduce office BP. This reduction is accompanied by the inability to lower ambulatory BP from the normal values characterizing this condition at baseline.