bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technology-facilitated sexual violence: a review of virtual violence against women
Authors: Araújo Ana Valentina Medeiros de , Bonfim Cristine Vieira do , Bushatsky Magaly , Furtado Betise Mery Alencar 
Published: February 2022

With the modernization of technology, new virtual forms of violence have emerged and old ways of perpetrating violence against women have been exacerbated with the use of the internet and social networks. This study aimed to investigate the forms of violence against women on the internet. This is an integrative literature review of the electronc databases SciVerse Scopus, Medical Literature Analysis and Retrieval System Online and Scientific Electronic Library Online. The inclusion criteria were publications that occurred in the time span from January 2016 to July 2021, with the descriptors "Violence," "Internet," "Woman," "Gender," "Sexual Violence," "Sexual Harassment," "Intimate Partner Violence," and "Internet and Abuse". As a result of the review, 30 articles were selected. Nine categories of violence against women on the Internet were identified, included in the concept of sexual violence facilitated by technology, in addition to digital dating abuse and cyberbullying. The most commonly addressed categories were digital dating abuse, revenge porn, sexting, and online misogyny. Most of the studies found concluded greater online victimization for women than for men in all categories except cyberbullying.
Qualidade de vida e os métodos de comunicação alaríngea: uma revisão de escopo
Authors: Santos Laryssa da Cunha , Santos Thaynara Andrade , Silva Kelly da , Pellicani Ariane Damasceno 
Published: February 2022

Objetivo: apresentar um mapeamento dos estudos envolvendo a qualidade de vida de laringectomizados totais quanto aos métodos de comunicação alaríngea e instrumentos utilizados. Método: A pergunta a ser respondida é: “Quais os instrumentos, validados e confiáveis psicometricamente, utilizados para avaliar a qualidade de vida relacionada a comunicação alaríngea de laringectomizados totais?”. Para responder a essa pergunta foram definidos os seguintes critérios de elegibilidade, de acordo com o acrônimo: P- População - Laringectomizados totais, C- Conceito - Outra forma de comunicação alaríngea, C- Contexto- Qualidade de vida após laringectomia total. Após a definição dos critérios de elegibilidade, consulta à bases de dados com os descritores DeCS/MeSH e Emtree: “Laryngectomy, Quality of Life, Speech, Alaryngeal”, combinados com o operador boleano “AND” e para os idiomas português, inglês e espanhol. Resultados: foram obtidos 238 textos científicos, sendo 4 artigos na Lilacs,74 na PubMed, 21 na Embase, 92 na Scopus, 42 na Web of Science, zero (0) na OpenGrey, dois (2) no Google Acadêmico e três (3) na BDTD (Biblioteca Digital Brasileira de Teses e Dissertações). Conclussão: Os instrumentos mais utilizados para avaliar a qualidade de vida em laringectomizados totais são: Qualidade de Vida em Voz (QVV), seguido do University of Washington Quality of Life Questionnaire (UW-QOL), e dos protocolos EORTC Quality of Life Questionnaire (EORTC QLQ-C30), Instrumento Qualidade De Vida da Universidade De Michigan Head And Neck (HNQOL), Questionário de Qualidade de Vida -SF-36.
Enfrentamento dos profissionais de enfermagem nos cuidados a crianças oncológicas na terminalidade da vida
Authors: Henriques Carla de Moraes Ribeiro , Fassarella Bruna Porath Azevedo , Santos Larissa Christiny Amorim dos , Neves Keila do Carmo , Ribeiro Wanderson Alves , Amaral Fernando Salgado do , Alves Ana Lúcia Naves , Paula Enimar de , Castro Kemely de , Lins Rodrigo de Albuquerque 
Published: February 2022

A criança portadora de câncer em fase terminal requer atenção especial não somente pelo processo de finitude de vida, mas particularmente por sua fase de compreensão e necessidade de procedimentos dolorosos. Tem como objetivo entender o cuidado do enfermeiro a criança hospitalizada portadora de doença oncológica fora de possibilidade de cura. Para a realização do presente estudo, foi utilizado o método de pesquisa bibliográfica na busca de artigos científicos, consultando as bases de dados online BDENF, Lilacs e Google acadêmico, abrangendo a busca entre 2015 a 2020. O estudo evidenciou duas categorias: percepções e reações emocionais dos profissionais da enfermagem que assistem crianças com câncer e gestão de segurança e assistência de enfermagem na oncologia pediátrica. Conclui-se que O enfermeiro é um profissional multifacetado e com distintas competências e atribuições, onde câncer infantil provoca uma série de alterações, incluindo mudanças na capacidade funcional, física, mental e psicológica na atuação deste profissional, necessitando sempre de executar estratégias de autocuidado mediante a sua assistência prestada.
Value of Bile Acids in Diagnosing Hepatitis C Virus-Induced Liver Cirrhosis and Hepatocellular Carcinoma
Authors: Khalil Ashraf , ElSheashaey Azza , Abdelsameea Eman , Obada Manar , Bayomy F.F. Mohamed , El-Said Hala 
Published: February 2022

Background: Metabonomic studies have related bile acids to hepatic impairment, but their role in predicting hepatocellular carcinoma still unclear. The study aimed to examine the feasibility of bile acids in distinguishing hepatocellular carcinoma from post hepatitis C virus-induced liver cirrhosis.Methods: An ultra-performance liquid chromatography coupled with mass spectrometry measured 14 bile acids in patients with noncirrhotic post hepatitis C virus disease (n = 50), cirrhotic post hepatitis C virus disease (n = 50), hepatocellular carcinoma (n = 50), and control group (n = 50).Results: The spectrum of liver disease was associated with a significant increase in many conjugated bile acids. The fold changes in many bile acid concentrations showed a linear trend with hepatocellular carcinoma &gt; cirrhotic disease &gt; noncirrhotic disease &gt; healthy controls (p &lt; 0.05). Receiver operating characteristic curve analysis revealed five conjugated acids TCA, GCA, GUDCA, TCDCA, GCDCA, that discriminated hepatocellular carcinoma from noncirrhotic liver patients (AUC = 0.85–0.96) with a weaker potential to distinguish it from chronic liver cirrhosis (AUC = 0.41–0.64).Conclusion: Serum bile acids are associated primarily with liver cirrhosis with little value in predicting the progress of cirrhotic disease to hepatocellular carcinoma.
Mi-RNA-93 and Mi-RNA-152 in the Diagnosis of Type 2 Diabetes and Diabetic Retinopathy
Authors: Saleh A. A. , El-Hefnawy S. M. , Kasemy Z. A. , Alhagaa A. A. , Nooh M. Z. , Arafat E. S. 
Published: February 2022

Background and Aim: Diabetes mellitus (DM) is a chronic disorder with diabetic retinopathy (DR) as one of its main microvascular outcomes, being a prime cause of vision loss. Dysregulation of microRNAs (miRNAs) has been associated with some diabetic microvascular complications such as diabetic retinopathy. This hypothesised changes in the serum of miR-93 and miR-152 in diabetes and diabetic retinopathy.Methods: The study cohort consisted of 80 healthy volunteers, 80 type 2 diabetic patients, and 80 diabetic retinopathy patients, of whom 40 had proliferative (PDR) and 40 non-proliferative retinopathy (NPDR). Serum fasting and 2-hour postprandial glucose (2hPP), glycated haemoglobin (HbA1c), fasting insulin, and HOMA-IR were evaluated by routine methods, miR-93 and miR-152 expression by quantitative real-time PCR.Results: FBG, 2hPP, fasting insulin, HOMA-IR, and miR-152 showed an increasing trend across groups while miR-93 showed a decreasing trend (all p &lt; 0.001). Binary logistic regression analysis for prediction of DR found that the most significant were miR-152 (OR 1.37, 95% CI: 1.18–1.58, &lt;0.001), BMI (1.13, [1.07–1.31], p = 0.004), duration of disease (1.29 [1.04–1.6] p = 0.018), and miR-152 (0.01, [0.0–0.47] p = 0.019). The most significant predictors of PDR were miR-152 (OR = 1.47, 95% CI: 1.12–1.92, p = 0.005), HOMA-IR (2.66 [1.30–5.45] p = 0.007), and miR-93 (0.25 [0.07–0.86] p = 0.028).Conclusion: MiR-93 and miR-152 can differentiate patients with diabetes and those with DR. Both miRNAs might be potential biomarkers for diabetes and diabetic retinopathy, and specifically for proliferative diabetic retinopathy.
Impact of Thyroid Tissue Status on the Cut-Off Value of Lymph Node Fine-Needle Aspiration Thyroglobulin Measurements in Papillary Thyroid Cancer
Authors: Zhai L. , Jiang W. , Zang Y. , Gao Y. , Jiang D. , Tian Q. , Zhao C. 
Published: February 2022

Objective: To study the optimal cut-off value of thyroglobulin measurement in a fine-needle aspiration (FNA-Tg) in diagnosing malignant lymph nodes and benign lymph nodes (LNs) according to the thyroid tissue status.Methods: A total of 517 LNs were aspirated: 401 preoperative LNs, 42 LNs after subtotal thyroidectomy and 74 suspected LNs after total thyroidectomy. The cut-off value of FNA-Tg was obtained from receiver operating characteristic (ROC) analysis. The cut-off value with the best diagnostic performance was then obtained by comparing different cut-off values from other studies.Results: LN FNA-Tg levels differed between preoperative and total thyroid disease (p &lt; 0.001) and subtotal thyroidectomy and total thyroidectomy (p = 0.03), but not between preoperative and subtotal thyroidectomy (p = 1.00). Accordingly, those 443 LNs with preoperative and subtotal thyroidectomy were compared to those 74 without thyroid tissue. The optimal cut-off value in thyroid tissue group was 19.4 ng/ml and the area under the ROC curve (AUC) was 0.95 (95% CI 0.92–0.97). The optimal cut-off value in thyroid tissue absence group was 1.2 ng/ml and the AUC was 0.93 (0.85–0.98). After the analysis and comparison of multiple cut-off values, the optimal diagnostic performance was still found to be 19.4 ng/ml and 1.2 ng/ml.Conclusion: The influential factors of FNA-Tg are still controversial, and the optimal cut-off value of FNA-Tg can be determined based on the presence or absence of thyroid tissue. FNA-Tg can be used as an important auxiliary method for diagnosing cervical metastatic LNs of thyroid cancer.
Genotypes and Haplotypes in the AXIN2 and TCF7L2 Genes are Associated With Susceptibility and With Clinicopathological Characteristics in Breast Cancer Patients
Authors: Rosales-Reynoso M. A. , Rosas-Enríquez V. , Saucedo-Sariñana A. M. , Pérez-Coria M. , Gallegos-Arreola M. P. , Salas-González E. , Barros-Núñez P. , Juárez-Vázquez C. I. , Flores-Martínez S. E. , Sánchez-Corona J. 
Published: February 2022

Background: Breast cancer is a multifactorial disease whose genetic susceptibility is related to polymorphic variants of cell proliferation and migration pathways. Variants in AXIN2 and TCF7L2 in the Wnt-β catenin pathway have been associated with different types of cancer; however, little is known about its role in breast cancer. This study tests the hypothesis of links between AXIN2 rs1133683 and rs2240308, and TCF7L2 rs7903146 and rs12255372 variants in breast cancer.Methods: Peripheral blood samples were obtained from 404 women (202 patients and 202 control females). The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology was used to identify the gene variants.Results: The AXIN2 rs2240308 (C &gt; T), and TCF7L2 rs7903146 (C &gt; T) and rs12255372 (G &gt; T) variants were associated with breast cancer and with age, TNM stage, and histologic-molecular subtype (p = 0.001). Likewise, the haplotype T-T in the TCF7L2 gene (rs7903146-rs12253372) was significantly related with breast cancer (OR = 2.66, 95%, CI = 1.64–4.30, p = 0.001).Conclusion: Our data show a link between AXIN2 rs2240308 and TCF7L2 rs7903146 and rs12255372 variants in breast cancer, and speculate this may be important in pathogenesis.
Highly Transparent, Self-Healing, and Self-Adhesive Double Network Hydrogel for Wearable Sensors
Authors: Chen Kai , Liu Mingxiang , Wang Feng , Hu Yunping , Liu Pei , Li Cong , Du Qianqian , Yu Yongsheng , Xiao Xiufeng , Feng Qian 
Published: February 2022

Hydrogel-based flexible electronic devices are essential in future healthcare and biomedical applications, such as human motion monitoring, advanced diagnostics, physiotherapy, etc. As a satisfactory flexible electronic material, the hydrogel should be conductive, ductile, self-healing, and adhesive. Herein, we demonstrated a unique design of mechanically resilient and conductive hydrogel with double network structure. The Ca2+ crosslinked alginate as the first dense network and the ionic pair crosslinked polyzwitterion as the second loose network. With the synthetic effect of these two networks, this hydrogel showed excellent mechanical properties, such as superior stretchability (1,375%) and high toughness (0.57 MJ/m3). At the same time, the abundant ionic groups of the polyzwitterion network endowed our hydrogel with excellent conductivity (0.25 S/m). Moreover, due to the dynamic property of these two networks, our hydrogel also performed good self-healing performance. Besides, our experimental results indicated that this hydrogel also had high optical transmittance (92.2%) and adhesive characteristics. Based on these outstanding properties, we further explored the utilization of this hydrogel as a flexible wearable strain sensor. The data strongly proved its enduring accuracy and sensitivity to detect human motions, including large joint flexion (such as finger, elbow, and knee), foot planter pressure measurement, and local muscle movement (such as eyebrow and mouth). Therefore, we believed that this hydrogel had great potential applications in wearable health monitoring, intelligent robot, human-machine interface, and other related fields.
Identification of Cardiac CircRNAs in Mice With CVB3-Induced Myocarditis
Authors: Nie Xiang , Fan Jiahui , Li Huihui , Wang Jin , Xie Rong , Chen Chen , Wang Dao Wen 
Published: February 2022

Background:Viral myocarditis could initiate various immune response to the myocardium, resulting in myocyte damage and subsequent cardiac dysfunction. The expression profile and functions of circRNAs in this process are unknown.Methods:Fulminant myocarditis (FM) and non-FM models were induced by coxsackie B3 virus (CVB3) infection in A/J mice and C57BL/6 mice, respectively. CircRNAs expression profile was identified by RNA-seq. Quantitative RT-PCR, Spearman rank correlation, KEGG pathway, GO analysis, Western blot and flow cytometry were performed for functional analysis.Results:Severer inflammatory cell infiltration and cardiomyocyte necrosis were presented in CVB3-treated A/J mice than those in C57BL/6 mice. The dysregulated circRNAs in both of the mouse strains displayed strong correlation with the immune response, but dysregulated circRNAs in A/J mice were more prone to cardiac dysfunction. KEGG analysis indicated that the target genes of dysregulated circRNAs in A/J mice were mainly involved in viral infection, T cell and B cell receptor signaling pathways, while the target genes of dysregulated circRNAs in C57BL/6 mice were unrelated to immune pathways. Furthermore, knockdown of circArhgap32 that was downregulated in CVB3-treated A/J mice promoted cardiomyocyte apoptosisin vitro.Conclusion:Our data showed that cardiac circRNAs dysregulation is an important characteristic of viral myocarditis.
Rapid Detection and Differentiation of Legionella pneumophila and Non-Legionella pneumophila Species by Using Recombinase Polymerase Amplification Combined With EuNPs-Based Lateral Flow Immunochromatography
Authors: Du Jungang , Ma Biao , Li Jiali , Wang Yaping , Dou Tianyu , Xu Shujuan , Zhang Mingzhou 
Published: February 2022

Legionella, a waterborne pathogen, is the main cause of Legionnaires’ disease. Therefore, timely and accurate detection and differentiation of Legionella pneumophila and non-Legionella pneumophila species is crucial. In this study, we develop an easy and rapid recombinase polymerase amplification assay combined with EuNPs-based lateral flow immunochromatography (EuNPs-LFIC-RPA) to specifically distinguish Legionella pneumophila and non-Legionella pneumophila. We designed primers based on the mip gene of Legionella pneumophila and the 5S rRNA gene of non-Legionella pneumophila. The recombinase polymerase amplification reaction could go to completion in 10 min at 37°C, and the amplification products could be detected within 5 min with EuNPs-LFIC strips. Using a florescent test strip reader, the quantitative results were achieved by reading the colored signal intensities on the strips. The sensitivity was 1.6 × 101 CFU/ml, and a linear standard linear curve plotted from the test strip reader had a correlation coefficient for the determination of Legionella pneumophila (R2 = 0.9516). Completed concordance for the presence or absence of Legionella pneumophila by EuNPs-LFIC-RPA and qPCR was 97.32% (κ = 0.79, 95% CI), according to an analysis of practical water samples (n = 112). In short, this work shows the feasibility of EuNPs-LFIC-RPA for efficient and rapid monitoring of Legionella pneumophila and non-Legionella pneumophila in water samples.
Functional Unit Construction for Heat Storage by Using Biomass-Based Composite
Authors: Su Jingtao , Weng Mengman , Lu Xiang , Xu Weihao , Lyu Sha , Liu Yidong , Min Yonggang 
Published: February 2022

How to construct a functional unit for heat storage by using biomass materials is significant for the exploration of phase change materials (PCMs). In this work, we try to design and construct a functional unit for heat storage by employing a vacuum impregnation method to prepare sugarcane-based shape stabilized phase change materials (SSPCMs) for improving the thermal conductivity of phase change materials (PCMs) and preventing the liquid state leakage of PCMs. The morphologies of the prepared materials are characterized by Scanning electron microscope (SEM) as containing a unique channel structure which is viewed as the key factor for heat storage. X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FT-IR), and thermogravimetric analysis (TGA) were used to characterize the prepared materials. The results indicated that no chemical reaction occurred between PEG and sugarcane-based biomass during the preparation process and SSPCMs showed great thermal stability. Their thermal properties are measured by using the differential scanning calorimetry (DSC) characterization and show a high melting enthalpy of 140.04 J/g and 94.84% of the relative enthalpy efficiency, illustrating the excellent shape stabilized phase change behavior. Moreover, the highest thermal conductivity of SSPCMs is up to 0.297 W/(mK), which is 28.02% higher than that of the pristine PEG. The excellent capability for thermal energy storage is attributed to the directional thermal conduction skeletons and perfect open channels and the unique anisotropic three-dimensional structure of the SSPCMs. Hence, the unique structure with PEG is testified as the functional unit for heat storage. Comprehensively considering the excellent properties of sugarcane-based materials—providing cheap raw materials via green preparation—it is conceived that sugarcane-based materials could be applied in many energy-related devices with reasonable function unit design.
Revascularization vs. Conservative Medical Treatment in Patients With Chronic Kidney Disease and Coronary Artery Disease: A Meta-Analysis
Authors: Liao Guang-zhi , Li Yi-ming , Bai Lin , Ye Yu-yang , Peng Yong 
Published: February 2022

BackgroundAs a strong risk factor for coronary artery disease (CAD), chronic kidney disease (CKD) indicates higher mortality in patients with CAD. However, the optimal treatment for the patients with two coexisting diseases is still not well defined.MethodsTo conduct a meta-analysis, PubMed, Embase, and the Cochrane database were searched for studies comparing medical treatment (MT) and revascularization [percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG)] in adults with CAD and CKD. Long-term all-cause mortality was evaluated, and subgroup analyses were performed.ResultsA total of 13 trials met our selection criteria. Long-term (with at least a 1-year follow-up) mortality was significantly lower in the revascularization arm [relative risk (RR) = 0.66; 95% CI = 0.60–0.72] by either PCI (RR = 0.61; 95% CI = 0.55–0.68) or CABG (RR = 0.62; 95% CI = 0.46–0.84). The results were consistent in dialysis patients (RR = 0.68; 95% CI = 0.59–0.79), patients with stable CAD (RR = 0.75; 95% CI = 0.61–0.92), patients with acute coronary syndrome (RR = 0.62; 95% CI = 0.58–0.66), and geriatric patients (RR = 0.57; 95% CI = 0.54–0.61).ConclusionIn patients with CKD and CAD, revascularization is more effective in reducing mortality than MT alone. This observed benefit is consistent in patients with stable CAD and elderly patients. However, future randomized controlled trials (RCTs) are required to confirm these findings.
Cheyne-Stokes Breathing as a Predictive Indicator of Heart Failure in Patients With Obstructive Sleep Apnea; A Retrospective Case Control Study Using Continuous Positive Airway Pressure Remote Monitoring Data
Authors: Saito Kimimasa , Takamatsu Yoko 
Published: February 2022

ObjectiveWe conducted a retrospective case control study to examine whether remote monitoring of Cheyne-Stokes breathing (CSB) was useful for predicting the onset of heart failure (HF) in patients with obstructive sleep apnea (OSA) on continuous positive airway pressure (CPAP).MethodsAmong patients with OSA treated at our hospital, 33 patients with HF that occurred between July 2014 and May 2021 [11 patients with acute HF (AHF); 22 patients with chronic HF (CHF) exacerbation] were included in the HF group. Of the 618 stable patients, 149 patients with a 30-days average CSB rate (CSB%) ≧1% were included in the non-HF control group. The chronologic change of CSB% were compared among the AHF, CHF and Control groups. Furthermore, of the 149 patients in the non-HF control group, 44 patients were matched for CSB%, body mass index, and sex in a ratio of 1:2 to 22 patients with CHF. The average cycle length (CL) of CSB was compared among three groups: CHF in stable period (CHF-stable group), CHF in exacerbation period (CHF-exacerbation group), and control group. In addition, according to the status of HF, receiver operating characteristic (ROC) curves were generated to determine the optimal cut-off points for variation of CSB% and CL.ResultsChronological change in CSB% among the three groups was significantly different. Standard deviation of CSB% (SD CSB%) before onset HF was significantly higher in both the AHF and CHF groups than in the control group. The CL of CSB was significantly longer in the CHF group than in the control group and was longer during the exacerbation period than during the stable period. The optimal cut-off value of CL that could differentiate patients with and without the onset of HF was 68.9 s.ConclusionThe HF group demonstrated greater CSB variations and longer CL than the non-HF control group. Furthermore, the CL was longer during the exacerbation period of HF even in the same patient. These results suggest that remote monitoring of CPAP device data for CSB variations and CL might allow early prediction of the onset and exacerbation of HF.