bluuebunny/crossref_metadata_2025_split huggingface dataset:
A produção documental de Antonio Olavo: lutas e memórias do povo negro
Authors: Silva Luciene Maria , Rosário Daiane 
Published: August 2022

A contribuição do cinema documentário para a compreensão de fatos históricos e pautas contemporâneas tem se confirmado nos últimos anos com uma produção significativa de filmes, sobre temas variados. Este artigo aborda a obra do cineasta baiano Antonio Olavo, realizador de cinco filmes documentários de longa metragem, uma série para TV e diversos curtas e médias-metragens sobre a história social e, particularmente, a memória negra no Brasil. Buscamos compreender a trajetória profissional do cineasta entrelaçada com sua história de vida, as concepções sobre o fazer cinematográfico e as esferas de influências incorporadas em sua obra. Para isso apresentamos seus principais filmes, destacando a série documental Travessias Negras (2017) sobre trajetórias particulares de estudantes universitários cotistas, buscando referências nas narrativas que se articulam em continuidades e rupturas, evidenciando sentidos diante do padrão de discriminação racial que se faz presente na sociedade brasileira. Privilegiamos o entendimento sobre cinema e narratividades a partir de autores como Xavier (2003), Bernadet (2017), Benjamin (1994), Matos (2001), entre outros, e utilizamos entrevistas com o cineasta colocando em perspectiva suas percepções acerca das lutas históricas de resistência, sobre preconceito, racismo, políticas afirmativas e cinema negro.
Uma “nãobiografia” “nãonarrativa” de “Agripina é Roma-Manhattan”, de Hélio Oiticica
Authors: Japiassú de Queiroz Carlos Eduardo , Santos Paloma da Silva 
Published: August 2022

Este artigo considera que o conceito crítico de “nãonarração”, criado por Hélio Oiticica e aplicável ao seu filme curta-metragem “Agripina é Roma-Manhattan”, registrado na região da Wall Street na cidade de New York, sugere uma analogia com nossa reflexão sobre uma possível “nãobiografia” relativa às significações que sua protagonista estabelece com os ambientes de encenação. A personagem consiste em uma referência incompleta e indireta de Agripina Menor, mãe do imperador romano Nero, que vivera entre os anos 15 e 59 d.C.. Sem diálogos, sons ou legendas, as únicas remissões à Agripina são seu nome no título, duas personagens femininas e alguns edifícios cujos estilos arquitetônicos nos remetem ao período greco-romano clássico e ao avanço do império sobre o Norte da Europa, especialmente em sua versão cristianizada e expressa por uma igreja gótica presente na paisagem do filme. Objetivando verificar a pertinência da mencionada hipótese consultamos alguns teóricos da história, do cinema e das artes que trataram dos conceitos de narrativa, biografia e personagem de maneira crítica é relativa. Prosseguimos com uma análise do filme realizando algumas divisões sistemáticas a fim de corresponder os conteúdos e as sintaxes das cenas com nossos conceitos e hipótese.
Palavras-chave: Narrativa. Biografia. Cinema.
Cada intento es un nuevo comienzo. Cine y biografía en camino incierto, de Pablo García
Authors: Larrosa Jorge , García Pablo 
Published: August 2022

Ya desde Fuente Álamo. La caricia del tiempo, tu primera película, me sorprendió tu mirada limpia, amorosa, demorada, respetuosa, serena, carente de juicio. Encuentro ahora esa misma mirada pero más madura en esta tu última obra, Camino incierto, donde vuelvo a constatar tu capacidad para producir emociones hondas con medios increíblemente sencillos, casi franciscanos de tan pobres y humildes, de tan volcados hacia la belleza del mundo a cuyas criaturas cantaba. En esta película, esa contemplación admirada que es la tuya teje reflexiones en absoluto banales sobre uno de los temas, quizá el fundamental, que atraviesa tu obra: lo efímero y lo que dura, lo que se deshace y lo que permanece, lo que envejece (y muere) y lo que nace (y comienza), el paso del paso del tiempo, su leve y terrible caricia en los lugares, en las cosas, en las personas, pero también en los proyectos, en las ilusiones, en los deseos, en los trabajos y en los días. Como nos dice la bellísima (y sencillísima) canción que recogiste en una plaza de Lima, “por caminitos llenos de espinas, yo voy buscando nuevos caminos”.
Utilidad del tamizaje prenatal de enfermedad de Chagas congénita
Authors: Pimentel González Josefina , Escalante Rivas María José , Inojosa Mackenzie Rocío , Vergara Zuñiga Carolina 
Published: August 2022

La enfermedad de Chagas (EC) es una patología parasitaria producida por el Tripanosoma cruzi. Constituye, sobre todo su transmisión congénita, un problema de salud pública tanto para territorios endémicos como no endémicos, siendo la principal forma de contagio en Chile. Objetivos: Describir un caso de EC congénita y dar a conocer la utilidad del tamizaje prenatal. Caso Clínico: Recién nacida de pretérmino de 29 semanas, hija de madre multípara con antecedente de EC detectado en tamizaje prenatal de embarazo actual. Por el antecedente se realizó PCR de Tripanosoma cruzi a los 4 días de vida que resultó indetectable. A las 6 y 8 semanas de vida, respectivamente, presentó rash máculo eritematoso y cuadro febril asociado a dificultad respiratoria, ambos autolimitados. En fondo de ojo de seguimiento por prematuridad a las 8 semanas de vida, se observaron granulaciones retinales bilaterales por lo que se realizó estudio de TORCH resultando negativo. Simultáneamente a las 8 semanas, por el antecedente materno de EC, se realizó una segunda PCR de Tripanosoma cruzi que resultó positiva. Se informó visualización de tripomastigotes confirmándose el diagnóstico de EC congénita. Se trató con Nifurtimox presentando reacción adversa a los 35 días con neutropenia, regurgitaciones y peso estacionario, por lo que se sustituyó el medicamento por Benznidazol, con lo que completó 60 días de tratamiento. A 22 meses de seguimiento, se mantiene asintomática. Conclusiones: Es necesario aumentar los esfuerzos en la prevención, detección precoz de nuevos casos y estudio de familiares directos, siendo este reporte un ejemplo de la utilidad del tamizaje prenatal para la pesquisa y tratamiento precoz de nuevos casos de EC.
Somatropina y talla final en población pediátrica mexicana con deficiencia de hormona de crecimiento
Authors: Rivera-Hernández Aleida , Sánchez-García Fernanda , Zurita-Cruz Jessie , Balcazar-Hernandez Lourdes 
Published: August 2022

El tratamiento con hormona de crecimiento recombinante, o somatropina, incrementa el crecimiento lineal y es efectiva en la mejoría de la talla final en niños con deficiencia aislada de hormona de crecimiento (DAGH), sin embargo, la información disponible sobre estos resultados es escasa en la población Latina. Objetivo: evaluar el efecto de somatropina sobre la velocidad de crecimiento y talla final en niños mexicanos con DAGH, así mismo, determinar los factores asociados con la talla final. Pacientes y Método: Estudio retrospectivo en 50 niños con deficiencia aislada y severa de GH tratados con somatropina. Se evaluaron las características auxológicas antes de somatropina y al alcanzarse la talla final. Se incluyeron solo pacientes con deficiencia severa de GH, con valor pico de GH por debajo de 5 µg/L. Resultados: 40% (n = 20) fueron niñas. El Z-score para la talla basal fue de -2,6 ± 0,4 vs Z-score para la talla final de -1,6 ± 0,7, con un Z-score de ganancia de talla de 1 ± 0,6. El 92% (n = 46) alcanzó su potencial genético; la dosis de somatropina fue de 33 ± 0,5 µg/kg/día, con una duración del tratamiento de 4,16 ± 1,5 años; la mayor velocidad de crecimiento se observó durante el primer año. En el análisis multivariado se observó la asociación entre la talla final, talla objetivo genética (r = 0,30; p = 0,03, b = 0,7; p = 0,001) y dosis de somatropina (r = 0,63; p = 0,001, b = 0,30; p = 0,028). Conclusiones: El tratamiento con somatropina permite la normalización del crecimiento lineal y el logro del potencial genético de la talla en la mayoría de niños mexicanos con DAGH. La talla final esta asociada con la talla objetivo genética y dosis de somatropina, datos que apoyan la importancia del potencial genético y el efecto dosis-respuesta de somatropina al establecer el pronóstico de talla.
TIPE INTERAKSI BAKTERI PENYUSUN KONSORSIUM DALAM DEGRADASI PARAQUAT
Authors: ERYAH HENRI PIETHERSON 
Published: August 2022

Penelitian ini bertujuan untuk mengetahui tipe interaksi bakteri penyusun konsorsium. Penelitian ini merupakan penelitian experimental dengan rancangan acak lengkap dengan 3 kali pengulangan Data yang diperoleh dari penelitian ini berupa: 1) kadar residu paraquat dianalisis menggunakan spektrofotometer UV-Vis; 2) jumlah populasi bakteri (CFU/mL) dan waktu inkubasi; 3) perhitungan jumlah koloni bakteri atau Total Plate Count (TPC); dan 4) pengukuran nilai Optical Dencity (OD) isolat bakteri. Data dianalisis secara statistik, sedangkan data penurunan persentase degradasi herbisida paraquat diuji menggunakan Two-Way Analysis of Varians (ANOVA) (derajat signifikasi = 5%), dilanjutkan dengan uji duncan. Hasil uji interaksi bakteri penyusun konsorsium menunjukkan bahwa adanya hubungan sinergis antar bakteri penyusun konsorsium dalam mendegradasi paraquat Hasil uji dengan Kit dan identifikasi bakteri didapatkan hasil bahwa pq1 adalah spesies Pseudomonas stutzeri, pq4 adalah spesies Acinetobacter sp., dan pq6 adalah spesies Micrococcus sp. Selain itu, hasil penelitian
juga menunjukkan bahwa formulasi bakteri berpengaruh terhadap degradasi paraquat di tanah
ditunjukkan oleh formulasi bakteri pq4pq6 sebesar 76.4%, diikuti pq1pq4pq6 sebesar 68.1%, pq1pq6 56.3%, pq1pq4 53.3%. Persentase degradasi tertinggi ditunjukkan oleh pq4pq6 sebesar 76.4%.
Kata Kunci: konsorsium bakteri, degradasi paraquat.
De la presencialidad a la virtualidad en las actividades físico-deportivas: Un nuevo desafío.
Authors: Diaz Luis Gustavo , Tocto Lobato Jorge Giovanny , Lomas Badillo Pablo Luis , Díaz Peñafiel Dennys Andrés 
Published: August 2022

Introducción. El desarrollo tecnológico alcanzado en los últimos años y su expansión a diferentes áreas de las ciencias, generaron que se extendiera al área de la cultura física y el deporte, incorporando sus beneficios y repercusiones. Objetivo. Sistematizar las teorías precedentes relacionadas con la aplicación de las TICs en el proceso de enseñanza-aprendizaje de las actividades físicas- deportivas en la modalidad virtual. Metodología. Se utilizó una metodología descriptiva, no experimental basada en la Revisión Sistemática de la Literatura, mediante métodos teóricos, que acercaron los criterios de búsquedas relacionados con el tema. Resultados. 1. Queda demostrado que los recursos tecnológicos se han transformado en apoyos educativos, posibilitando que la educación virtual genere competencias que son requeridas actualmente 2. La educación virtual mediante las TICs, constituye un agente transformador del proceso de enseñanza-aprendizaje, permitiendo el desarrollo de competencias cognitivas que repercuten positivamente en los estudiantes al ser más activos, tener razonamiento, criterio y pensamiento propios. 3. La práctica de actividades físicas- deportivas en modalidad virtual no debe estar limitada únicamente a la potenciación de las capacidades físicas propiamente, sino también al fortalecimiento del pensamiento. 4. La virtualidad, constituye un reto para los docentes y profesionales de la actividad física y el deporte por la necesidad de crear espacios seguros de diálogo y reflexión, a través del deporte, el juego y la actividad física adaptada 5. Se proponen acciones conducentes a sistematizar el uso de las TISc en el contexto de las actividades físicas -deportivas. Conclusiones. La educación virtual se ha convertido en un agente de transformación positiva del proceso de enseñanza-aprendizaje, constituyendo una oportunidad esencial en el contexto de la práctica de actividades físicas -deportivas, sistematizándose su valía, para la adquisición de competencias cognitivas y motrices, así como para el desarrollo de la motivación, el pensamiento lógico y creativo.
How has the COVID-19 Pandemic Affected Diabetes Self-Management in People With Diabetes? - A One-Year Follow-Up Study
Authors: Olesen Kasper , Joensen Lene Eide , Madsen Kristoffer Panduro , Willaing Ingrid 
Published: August 2022

Background and AimIn Denmark, the COVID-19 pandemic resulted in two lockdowns, one from March to May 2020 and another from December 2020 to April 2021, which had severe impact on everyday life. The aim of this study was to explore changes in diabetes self-management behaviors during the pandemic and to examine how specific population characteristics were associated with changes in diabetes management.Methods and ParticipantsIn a cohort study from March 2020 to April 2021, two online questionnaires were collected from a total of 760 people with diabetes. Descriptive statistics were used to assess the proportion of participants experiencing improvements, deterioration, and status quo in diabetes self-management during the pandemic. Using logistic regressions, baseline characteristics were explored as potential predictors of change.ResultsApproximately half of the participants reported that they experienced lower physical activity in April 2021 compared to before the pandemic, approximately one fifth reported diabetes self-management to be more difficult than prior to the pandemic, and one fifth reported eating more unhealthily than before the pandemic. Some participants reported higher frequency of high blood glucose levels (28%), low blood glucose levels (13%) and more frequent blood glucose variability (33%) compared to before. Easier diabetes self-management was reported by relatively few participants, however, 15% reported eating more healthily, and 20% reported being more physically active. We were largely unable to identify predictors of change in exercise activities. The few baseline characteristics identified as predictors of difficulties in diabetes self-management and adverse blood glucose levels due to the pandemic were sub-optimal psychological health, including high diabetes distress levels.ConclusionFindings indicate that many people with diabetes changed diabetes self-management behaviors during the pandemic, mostly in a negative direction. Particularly high diabetes distress levels in the beginning of the pandemic was a predictor of both positive and negative change in diabetes self-management, indicating that people with high diabetes distress levels could potentially benefit from increased support in diabetes care during a period of crisis.
HER2-low expression does not affect the clinical outcomes of metastatic breast cancer treated with CDK4/6 inhibitor: A real-world study
Authors: Shao Yingbo , Luo Zhifen , Yu Yang , Chen Qi , He Yaning , Liu Chaojun , Nie Bing , Zhu Fangyuan , Liu Hui 
Published: August 2022

BackgroundThere is accumulating evidence support human epidermal growth factor receptor 2 (HER2)-low as a biologically distinct subtype of breast cancer. The present study was conducted to explore whether HER2-low expression will affect the clinical efficacy of cyclin-dependent kinase (CDK) 4/6 inhibitor for patients with hormone receptor (HR)-positive, HER-2 negative metastatic breast cancer.MethodsPatients with HR+/HER2- metastatic breast cancer who were treated with palbociclib from January 2019 to June 2021 were retrospectively analyzed based on real-world clinical practice. HER2-zero was defined as immunohistochemistry (IHC) 0, and HER2-low was defined as IHC 1+ or IHC 2+/fluorescence in situ hybridization (FISH) negative. The primary end point was progression free survival (PFS), and the secondary end points were objective response rate (ORR), disease control rate (DCR), overall survival(OS) and safety.Results45 patients received palbociclib plus aromatase inhibitor (AI) or fulvestrant therapy, including 24 HER-2-zero and 21 HER-2-low patients. There were no statistically significant differences in clinicopathological characteristics between the two groups. No significant differences were observed in ORR (41.7% vs. 28.6%, P=0.360) and DCR (79.2% vs. 76.2%, P=0.811) between HER-2-zero and HER-2-low patients. And simultaneously, HER2-zero and HER2-low patients obtained similar median PFS (16.2m vs. 14.1m, P=0.263). The median OS was not reached. Neutropenia and leukopenia were the most common adverse events. Grade 3-4 adverse events(AEs) occurred in 58.3% and 57.1% of patients, respectively.ConclusionsHER2-low expression does not affect the clinical efficacy of palbociclib and our present study did not support incorporating HER2-low into systemic therapy decisions for patients with HR+/HER2- metastatic breast cancer treated with CDK4/6 inhibitor.
Epileptic seizures during Non-Ketotic Hyperglycemia (NKH) in French Guiana: A retrospective study
Authors: Baltyde Dimitri , De Toffol Bertrand , Nacher Mathieu , Sabbah Nadia 
Published: August 2022

IntroductionEpileptic seizures during non-ketotic hyperglycemia (NKH) represent a rare complication of uncontrolled diabetes mellitus. The definition associates a blood sugar level &gt; 200mg/dL (11mmol/L), hyperosmolality, absence of ketosis, dehydration and seizure control after normalization of blood sugar levels.Material and methodsThis retrospective observational study included patients hospitalized for epileptic seizures and NKH in the Cayenne Hospital Center between January 2010 and June 2020. The clinical, biological, and radiological results were collected.Results18 out of 228 (7.9%) patients with both diabetes and epileptic seizures had NKH. The mean age of the 12 women and 6 men was 64.8 years. In 8 patients, brain imaging did not show acute lesions and the seizures disappeared with control of hyperglycemia by hydration and insulin. In 6 patients, the seizures revealed a stroke, hemorrhagic in 4 cases, ischemic in 2 cases. 4 patients had a seizure in a context of known vascular epilepsy. The epileptic seizures were mainly focal seizures with motor symptoms that could be repeated, focal to bilateral tonic-clonic or focal status.ConclusionSeizures in NKH are symptomatic of an acute brain lesion or vascular epilepsy more than 1 in 2 times. However, isolated NKH can cause seizures with a suggestive brain MRI.
Emerging phenotypes linked to variants in SAMD9 and MIRAGE syndrome
Authors: Suntharalingham Jenifer P. , Ishida Miho , Del Valle Ignacio , Stalman Susanne E. , Solanky Nita , Wakeling Emma , Moore Gudrun E. , Achermann John C. , Buonocore Federica 
Published: August 2022

BackgroundHeterozygous de novo variants in SAMD9 cause MIRAGE syndrome, a complex multisystem disorder involving Myelodysplasia, Infection, Restriction of growth, Adrenal hypoplasia, Genital phenotypes, and Enteropathy. The range of additional clinical associations is expanding and includes disrupted placental development, poor post-natal growth and endocrine features. Increasingly, milder phenotypic features such as hypospadias in small for gestational age (SGA) boys and normal adrenal function are reported. Some children present with isolated myelodysplastic syndrome (MDS/monosomy 7) without MIRAGE features.ObjectiveWe aimed to investigate: 1) the range of reported SAMD9 variants, clinical features, and possible genotype-phenotype correlations; 2) whether SAMD9 disruption affects placental function and leads to pregnancy loss/recurrent miscarriage (RM); 3) and if pathogenic variants are associated with isolated fetal growth restriction (FGR).MethodsPublished data were analyzed, particularly reviewing position/type of variant, pregnancy, growth data, and associated endocrine features. Genetic analysis of SAMD9 was performed in products of conception (POC, n=26), RM couples, (couples n=48; individuals n=96), children with FGR (n=44), SGA (n=20), and clinical Silver-Russell Syndrome (SRS, n=8), (total n=194).ResultsTo date, SAMD9 variants are reported in 116 individuals [MDS/monosomy 7, 64 (55.2%); MIRAGE, 52 (44.8%)]. Children with MIRAGE features are increasingly reported without an adrenal phenotype (11/52, 21.2%). Infants without adrenal dysfunction were heavier at birth (median 1515 g versus 1020 g; P &lt; 0.05) and born later (median 34.5 weeks versus 31.0; P &lt; 0.05) compared to those with adrenal insufficiency. In MIRAGE patients, hypospadias is a common feature. Additional endocrinopathies include hypothyroidism, hypo- and hyper-glycemia, short stature and panhypopituitarism. Despite this increasing range of phenotypes, genetic analysis did not reveal any likely pathogenic variants/enrichment of specific variants in SAMD9 in the pregnancy loss/growth restriction cohorts studied.ConclusionMIRAGE syndrome is more phenotypically diverse than originally reported and includes growth restriction and multisystem features, but without adrenal insufficiency. Endocrinopathies might be overlooked or develop gradually, and may be underreported. As clinical features including FGR, severe infections, anemia and lung problems can be non-specific and are often seen in neonatal medicine, SAMD9-associated conditions may be underdiagnosed. Reaching a specific diagnosis of MIRAGE syndrome is critical for personalized management.
FT3/FT4 ratio is correlated with all-cause mortality, cardiovascular mortality, and cardiovascular disease risk: NHANES 2007-2012
Authors: Lang Xueyan , Li Yilan , Zhang Dandan , Zhang Yuheng , Wu Nilian , Zhang Yao 
Published: August 2022

BackgroundThyroid hormones play a vital role in maintaining the homeostasis of the cardiovascular system. The FT3/FT4 ratio can be used to evaluate the rate of T4-to-T3 conversion, reflecting the peripheral sensitivity of thyroid hormones. There is no study to investigate its relationship with death and cardiovascular disease (CVD) in the general population.MethodsThis retrospective cohort study involved 8,018 participants with measured thyroid function and no prior thyroid disease who participated in the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2012. Mortality status was determined by routine follow-up using the National Death Index through December 31, 2015.ResultsDuring a median of 87 months of follow-up, we observed 699 all-cause deaths, including 116 cardiovascular deaths. In multivariate adjusted models, higher free thyroxine (FT4) was linked to increased all-cause mortality (HR, 1.15 per SD; 95% CI, 1.09-1.22), cardiovascular mortality (HR, 1.18 per SD; 95% CI, 1.01-1.39), and CVD risk (HR, 1.17 per SD; 95% CI, 1.08-1.27). Higher free triiodothyronine (FT3) was linked to decreased all-cause mortality (HR 0.81 per SD; 95% CI, 0.70-0.93). Higher FT3/FT4 ratio was linked to decreased all-cause mortality (HR, 0.77 per SD; 95% CI, 0.69-0.85), cardiovascular mortality (HR, 0.79 per SD; 95% CI, 0.62-1.00), and CVD risk (HR, 0.82 per SD; 95% CI, 0.74-0.92). The FT3/FT4 ratio stratified findings were broadly consistent with the overall results.ConclusionsFT3, FT4, and the FT3/FT4 ratio were all independent predictors of all-cause death. FT4 and the FT3/FT4 ratio, but not FT3, were independent predictors of cardiovascular mortality and CVD risk. Along with FT3 and FT4, we should pay equal attention to the FT3/FT4 ratio in the general population.