bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epitope Based Vaccine Peptide Predictions for fimH gene of Acinetobacter baumannii
Authors: Devika B. , Girija A. S. Smiline , Ganesh P. Sankar , Priyadharsini J. Vijayashree 
Published: January 2022

Background: Acinetobacter baumannii is an opportunistic bacterial pathogen that is primarily associated with hospital-acquired infections. Recently, there is a dramatic increase in the incidence of multidrug-resistant (MDR) strains, which has significantly raised the profile of this emerging opportunistic pathogen. MDR is often associated with the formation of biofilms and various other virulence factors. Amidst all the genes, fimH gene is our area of interest in this research, because it is an important virulence factor in A. baumannii which encodes the Type 1 fimbriae, that helps bacteria bind to the surface of host cells initiating further infection.
Aim: The aim of this study was to assess the epitope based vaccine epitope peptide predictions for the fimH protein of A. baumannii.
Materials and Methods: The fimH gene for epitope prediction was selected. Druggability and physico-chemical properties were analysed. Antigenicity was predicted. Epitope mapping of T-cell MHC class 1, Class 1 immunogenicity, conservancy and toxicity analysis was done. T-cell class II epitopes were further mapped together with the immuno-dominant B-cell epitopes.
Results: From the selected 20 epitopes, 2 best epitopes (AALVASVCL and YSSGANAFT) were selected after analysing their antigenicity and allergenicity. The epitope YSSGANAFT showed better values in association with HLA alleles - HLA-DP, HLA-DQ, HLA-DR and TLR-2.
Conclusion: The finding of the study documents a single immunodominant peptide (sequence) as a promising vaccine candidate to treat infections caused by A. baumannii. However further experimental analysis must be performed to assess the immunological memory and response of the peptide in both in-vitro and in-vivo studies.
Assessment of Oral Health Care Needs among Fishermen Living in North Chennai, India – A Cross Sectional Study
Authors: Nithya V. R. , Krithika Chandrasekaran , Sridhar Chitathoor , Arumugam A. Edeinton 
Published: January 2022

Introduction: Studies conducted among fishermen shows that there was a high prevalence rate in Oral mucosal lesions. However, data on oral health care needs among fisherman is scarce. Hence this was undertaken to obtain a data that can be used to plan programmes for the prevention and treatment of such oral mucosal lesions in the fishermen.
Materials and Methods: A study was carried out among 71 fishermen after obtaining clearance from the institutional ethical committee and concerned authorities. A self administered questionnaire is distributed among the study group comprising questions relating to personal history and deleterious habits. Clinical examination was carried out using mouth mirror, explorer and under proper illumination. Oral health examination was done using WHO Basic Oral health Assessment proforma, 2013. Data collected and analysed statistically using SPSS software.
Results: Among the 71 fishermen, 56(78.9%) were males and 15 (21.1 %) were females. In the study population, 44(62%) were tobacco chewers, 39(54.9%) were snuff users, 24(33.8%) were alcohol consumers and 19(26.8%) were smokers. Smokeless tobacco (41.5%) was the most common deleterious habit after which by alcohol consumption (33.8%) and smoking (26.8%).The prevalence of oral mucosal lesions was 20.8%.It was found that statistically significant association existed between the deleterious habits and leukoplakia.
Conclusion: According to the our study, the prevalence of oral mucosal lesions was 20.8% among the fishermen who had a clear association with deleterious habits such as tobacco chewing, smoking, alcohol consumption and snuff.
High‐Resolution Erasable “Live” Patterns Based on Controllable Ink Diffusion on the 3D Blue‐Phase Liquid Crystal Networks
Authors: Meng Fanshu , Zheng Chenglin , Yang Wenjie , Guan Bo , Wang Jingxia , Ikeda Tomiki , Jiang Lei 
Published: January 2022

AbstractColorful blue phase liquid crystal (BPLC) patterns have attracted wide research attention owing to their intriguing and advantageous properties and promising applications. However, it remains a challenge to develop novel and high‐resolution patterns from BPLC owing to the complicated synthetic procedure for the functional molecules. This study reports a high‐resolution “live” pattern by well‐designed diffusion of 5CB ink on the wettability‐modified BPLC networks. Interestingly, the shape and color of the as‐prepared pattern change with time, which results in unique spectra change of the printed pattern, “first red‐shift and subsequent blue‐shift of the stopband position” and “continuous growth in reflectivity intensity” with time. The hydrophobic substrate greatly suppresses the random spreading and diffusion of ink, contributing to high‐resolution patterns. The promising applications of live patterns for program display and active labels are demonstrated. Various high‐resolution erasable colorful patterns are obtained. The structure reconfiguration of the writing and erasing processes is proved by transmitted electronic microscope images and Kossel diffraction diagrams, which ensures the reversible writing/erasing of the pattern on the membrane. This work is of significance for the development of novel rewritable paper and high‐quality optic devices based on BPLC materials.
Patterning All‐Inorganic Halide Perovskite with Adjustable Phase for High‐Resolution Color Filter and Photodetector Arrays
Authors: Kim Woosik , Kim Su‐Kyung , Jeon Sanghyun , Ahn Junhyuk , Jung Byung Ku , Lee Sang Yeop , Shin Chanho , Seong Tae‐Yeon , Jeong Sohee , Jang Ho Seong , Ng TSe Nga , Oh Soong Ju 
Published: January 2022

AbstractPerovskite has been actively studied for optoelectronic applications, such as photodetectors and light‐emitting diodes (LEDs), because of its excellent optoelectronic properties. However, ionic bonds of the perovskite structure are vulnerable to chemicals, which makes perovskite incompatible with photolithography processes that use polar solvents. Such incompatibility with photolithography hinders perovskite patterning and device integration. Here, an all‐solution based cesium lead halide perovskite (CsxPbyBrz) patterning method is introduced in which PbBr2 is patterned and then synthesized into CsxPbyBrz. Each step of the top‐down patterning process (e.g., developing, etching, and rinsing) is designed to be compatible with existing photolithography equipment. Structural, chemical, and optical analyses show that the PbBr2 pattern of (10 µm)2 squares is successfully transformed into CsPbBr3 and Cs4PbBr6 with excellent absorption and emission properties. High‐resolution photoconductor arrays and luminescent pattern arrays are fabricated with CsPbBr3 and Cs4PbBr6 on various substrates, including flexible plastic films, to demonstrate their potential applications in image sensors or displays. The research provides a fundamental understanding of the properties and growth of perovskite and promotes technological advancement by preventing degradation during the photolithography process, enabling the integration of perovskite arrays into image sensors and displays.
Peritoneum‐Inspired Janus Porous Hydrogel with Anti‐Deformation, Anti‐Adhesion, and Pro‐Healing Characteristics for Abdominal Wall Defect Treatment
Authors: Liang Weiwen , He Wenyi , Huang Rongkang , Tang Youchen , Li Shimei , Zheng Bingna , Lin Yayu , Lu Yuheng , Wang Hui , Wu Dingcai 
Published: January 2022

AbstractImplantable meshes used in tension‐free repair operations facilitate treatment of internal soft‐tissue defects. However, clinical meshes fail to achieve anti‐deformation, anti‐adhesion, and pro‐healing properties simultaneously, leading to undesirable surgery outcomes. Herein, inspired by the peritoneum, a novel biocompatible Janus porous poly(vinyl alcohol) hydrogel (JPVA hydrogel) is developed to achieve efficient repair of internal soft‐tissue defects by a facile yet efficient strategy based on top‐down solvent exchange. The densely porous and smooth bottom‐surface of JPVA hydrogel minimizes adhesion of fibroblasts and does not trigger any visceral adhesion, and its loose extracellular‐matrix‐like porous and rough top‐surface can significantly improve fibroblast adhesion and tissue growth, leading to superior abdominal wall defect treatment to commercially available PP and PCO meshes. With unique anti‐swelling property (maximum swelling ratio: 6.4%), JPVA hydrogel has long‐lasting anti‐deformation performance and maintains high mechanical strength after immersion in phosphate‐buffered saline (PBS) for 14 days, enabling tolerance to the maximum abdominal pressure in an internal wet environment. By integrating visceral anti‐adhesion and defect pro‐healing with anti‐deformation, the JPVA hydrogel patch shows great prospects for efficient internal soft‐tissue defect repair.
2D FeP Nanoframe Superlattices via Space‐Confined Topochemical Transformation
Authors: Deng Yuwei , Xi Xiangyun , Xia Yan , Cao Yangfei , Xue Shuqing , Wan Siyu , Dong Angang , Yang Dong 
Published: January 2022

AbstractSelf‐assembled nanocrystal superlattices represent an emergent class of designer materials with potentially programmable functionalities. The ability to construct hierarchically structured nanocrystal superlattices with tailored geometry and porosity is critical for extending their applications. Here, 2D superlattices comprising monolayer FeP nanoframes are synthesized through a space‐confined topochemical transformation approach induced by the Kirkendall effect, using carbon‐coated Fe3O4 nanocube superlattices as a precursor. The particle shape and the close‐packed nature of Fe3O4 nanocubes as well as the interconnected carbon layer network contribute to the topochemical transformation process. The resulting 2D FeP nanoframe superlattices possess several unique and advantageous structural features that are unavailable in conventional 3D nanocrystal superlattices, which make them particularly attractive for catalytic applications. As a proof of concept, such 2D FeP nanoframe superlattices are harnessed as highly efficient and durable electrocatalysts for the hydrogen evolution reaction, the performance of which is superior to that of most FeP‐based catalysts reported previously. This topochemical transformation approach is scalable and general, representing a new route of designing hierarchical superlattices with highly open features that cannot be accessible by traditional self‐assembly methods.
Tris(pentafluorophenyl)borane‐Catalyzed Oxygen Insertion Reaction of α‐Diazoesters (α‐Diazoamides) with Dimethyl Sulfoxide
Authors: Wu Xiao‐Yang , Gao Wen‐Xia , Zhou Yun‐Bing , Liu Miao‐Chang , Wu Hua‐Yue 
Published: January 2022

AbstractA tris(pentafluorophenyl)borane‐catalyzed oxidation reaction of α‐diazoesters (α‐diazo amides) with dimethyl sulfoxide has been developed. The reaction proceeds under metal free conditions to afford a series α‐ketoesters and α‐ketoamides. The synthetic utility of this protocol is demonstrated through synthetic transformations and scaled‐up synthesis.magnified image
The impact of crop insurance on farm financial outcomes
Authors: DeLay Nathan D. , Brewer Brady , Featherstone Allen , Boussios David 
Published: January 2022

AbstractWe use data from the Kansas Farm Management Association to estimate the impact of crop insurance liability and insurance indemnities on farm debt. Subsidized crop insurance may increase farms' financial risk through a mechanism known as “risk balancing.” Previous findings in support of risk balancing may suffer from bias due to unobservable farm characteristics and simultaneity in insurance and debt decisions. Employing a simultaneous equations model with farm fixed effects, we find no statistical relationship between crop insurance liability and debt, calling into question the risk balancing hypothesis in federal crop insurance. We show that large insurance indemnity payments reduce farms' reliance on short‐term debt, but leave the total debt level unchanged.
Perceived utility and disutility of genomic sequencing for pediatric patients: Perspectives from parents with diverse sociodemographic characteristics
Authors: Halley Meghan C. , Young Jennifer L. , Fernandez Liliana , Kohler Jennefer N. ,   Undiagnosed Diseases Network, Bernstein Jonathan A. , Wheeler Matthew T. , Tabor Holly K. 
Published: January 2022

AbstractGiven the limited therapeutic options for most rare diseases diagnosed through genomic sequencing (GS) and the proportion of patients who remain undiagnosed even after GS, it is important to characterize a broader range of benefits and potential harms of GS from the perspectives of families with diverse sociodemographic characteristics. We recruited parents of children enrolled in the Undiagnosed Diseases Network. Parents completed an in‐depth interview, and we conducted a comparative content analysis of the data. Parents (n = 30) were demographically diverse, with 43.3% identifying as Hispanic, 33.3% primarily Spanish‐speaking, and widely variable household income and education. Parents reported minimal changes in their child's health status following GS but did report a range of other forms of perceived utility, including improvements in their child's healthcare management and access, in their own psychological well‐being, and in disease‐specific social connections and research opportunities. Parents who received a diagnosis more frequently perceived utility across all domains; however, disutility also was reported by both those with and without a diagnosis. Impacts depended on multiple mediating factors, including parents' underlying expectations and beliefs, family sociodemographic characteristics, individual disease characteristics, and prior healthcare access. Our study suggests that the perceived utility of GS varies widely among parents and may depend on multiple individual, sociodemographic, and contextual factors that are relevant for pre‐ and post‐GS counseling, for value assessment of GS, and for policymaking related to access to new genomic technologies.
Study on structural and functional properties of porous SiO2 core‐shell construction/polyethylene nanocomposites with enhanced interfacial interaction
Authors: Zhang Chuying , Zhao Hang , Yang Fan , Zhang Na , Zhu Tongguang , Leng Kunyue , Bai Jinbo 
Published: January 2022

AbstractThe addition of inorganic particles can endow polymer matrices with different new features, thereby realizing an optimization to the structural and functional properties of composite. The overall properties of composites are greatly influenced by both fillers dispersion and fillers‐polymer interfacial interaction. However, to simultaneously improve these mentioned two issues is still a critical challenge in the field of polymer‐based nanocomposite. Herein, a typical core‐shell structured mesoporous silica‐coated silica (SiO2@mSiO2) construction was successfully synthesized by using a bi‐phase method. The SiO2@mSiO2 filled polyethylene (PE) nanocomposite was fabricated through a precisely controlled melt‐mixing approach. Benefiting from the additional mesoporous SiO2 shell, both the dispersion of SiO2@mSiO2 and the SiO2@mSiO2‐PE matrix interfacial interaction are improved. Moreover, the stress–strain behavior, temperature‐dependent mechanical property, thermal stability, and electrical insulating property of SiO2@mSiO2/PE composite were studied in detail. It is found that SiO2@mSiO2 core‐shell nanoparticles are capable of not only making a balance between the strength and toughness of the PE‐based composite, but also improving the thermal stability of the composite. In addition, the SiO2@mSiO2/PE composite exhibited an enhanced breakdown strength (256.4 MV·m−1) when filled with as small as 1 wt% SiO2@mSiO2, which is 108% higher than neat PE. All these optimized features are attributed to the well‐designed core‐shell structure. These experimental results provide a promising way to design and fabricate future advanced composite with excellent structural and functional properties in the future.
Solventless solid‐phase extraction using Zn ion‐imprinted polymer detected by colorimetric method
Authors: Lee Yelin , Ahn Soyoung , Cho Hansang , Ogunro Vincent , Bae Sunyoung 
Published: January 2022

AbstractIon‐imprinted polymers attract a lot of attention and are actively studied because of easy preparation and their high selectivity. Zn is known to be essential mineral in human body; however, when it is absorbed into our body, it is hardly discharged completely and causes various disease or side effects. To suggest new method for selective Zn extraction, Zn ion‐imprinted polymer (ZIIP) was synthesized by bulk polymerization and NZIIP (non‐ZIIP) was prepared as a control. Then, ZIIP and NZIIP were characterized by Fourier‐transform infrared spectroscopy, Scanning electron microscope, and X‐ray photoelectron spectroscopy to investigate structural changes during polymerization. Adsorption isotherm studies indicated that sigmoidal Langmuir isotherm equation was fitted well and the maximum adsorption capacity and affinity of Zn on ZIIP was superior to NZIIP. Dithizone was used to chelate with Zn in supernatant for colorimetric determination. ZIIP‐solid‐phase extraction potentially used as Zn ion filter was investigated showing good removal efficiency.
Determination, residue analysis, dietary risk assessment, and processing of flupyradifurone and its metabolites in pepper under field conditions using LC–MS/MS
Authors: Feng Yizhi , Zhang Aijuan , Bian Yanli , Liang Lin , Zuo Bojun 
Published: January 2022

AbstractAn effective method based on LC–MS/MS was established to determine the concentrations of flupyradifurone, difluoroacetic acid, and 6‐chloronicotinic acid in pepper. On the basis of this method, the dissipation, processing factor, and dietary risk of flupyradifurone in pepper were investigated. The results show that the half‐life of flupyradifurone in peppers was 2.6–3.8 days. The terminal residual concentration of flupyradifurone in the supervised trials was not higher than the maximum residue limit (MRL) for pepper in the Codex Alimentarius Commission (CAC) (0.9 mg kg−1) with the highest residual values of 0.53 mg kg−1. The national estimated daily intake of flupyradifurone was 0.00094 mg kg−1, based on the dietary structure of Chinese consumers and the terminal residues under field conditions. The risk quotient for flupyradifurone was 0.012, which was significantly < 1. The processing factor of flupyradifurone in dried pepper was 10.9–14.2, which indicated that drying increased the residual amounts of flupyradifurone in dried pepper, but the residual concentration was still lower than its MRL of 9 mg kg−1 established by CAC.
Ionic Liquid Modified Active Edge‐Rich Antimonene Nanodots for Highly Efficient Electrocatalytic Hydrogen Evolution Reaction
Authors: Wang Jingkun , Wang Chengqiang , Song Yanhui , Sha Wenbo , Wang Zhiyuan , Cao Hailiang , Zhao Min , Liu Peizhi , Guo Junjie 
Published: January 2022

AbstractTwo‐dimensional (2D) monoelemental antimonene has aroused great research interest since it emerged as a promising electrocatalyst for the hydrogen evolution reaction (HER). Nevertheless, the catalytic efficiency of the reported antimonene catalysts has been limited by their poor conductivity and low‐density of exposed active sites. Herein, the active edge sites engineering is adopted to expose abundant catalytically active edge sites by decreasing the size of antimonene nanosheets to ultrasmall‐sized antimonene nanodots (AMNDs). Meanwhile, the synergy effect of the surface modulation strategy by decorating the base surface of AMNDs using the ionic liquid benefits the mass transfer during the HER process. Impressively, the ionic liquid modified AMNDs (noted as IL‐AMNDs) achieve a low overpotential of 116 mV at the current density of 10 mA cm−2 and excellent long‐term durability, even superior to many other previously reported 2D catalysts. This work spreads the way out for the development of highly active and efficient hydrogen production catalysts.
Enhanced Electroconversion CO2‐to‐Formate by Oxygen‐Vacancy‐Rich Ultrasmall Bi‐Based Catalyst Over a Wide Potential Window
Authors: Wang Xueli , Zhang Lu‐Hua , Chen Datong , Zhan Jiayu , Guo Jiangyi , Zhang Zisheng , Yu Fengshou 
Published: January 2022

AbstractBi‐based materials quickly rise as promising candidates for electrochemical CO2‐to‐formate conversion. However, most of them only display a narrow potential range for the desired formate selectivity. Herein, we designed an oxygen‐vacancy‐rich ultrasmall bismuth subcarbonate supported on reduced graphene oxide composite (Vo‐BOC/G) for electrochemical CO2‐to‐formate conversion. The Vo‐BOC/G exhibits an outstanding formate selectivity up to 100 % at −1.2 V vs. RHE and an impressive partial current density of 38 mA cm−2 in 0.1 M KHCO3. More importantly, the considerable formate selectivity (>80 %) was obtained over an impressively wide potential range of 600 mV, superior over most of reported Bi‐based electrocatalysts under the same conditions. Theoretical results show the abundant Vo defects significantly lower energy barrier for *CO2 formation, resulting in high formate selectivity over a wider potential window. This work may pave the way for Bi‐based materials application in different renewable energy‐conversion devices.
Inhibition of p‐Nitrothiophenol Catalytic Hydrogenation on Ag‐Containing AgAu/Pd/TiO2 Plasmonic Catalysts Probed in situ by SERS
Authors: Lopes Douglas S. , Vono Lucas L. R. , Miranda Ester V. , Ando Rômulo A. , Corio Paola 
Published: January 2022

AbstractCompositional variations of surface‐enhanced Raman scattering (SERS)‐active catalysts play an essential role and can drastically affect the reaction pathway, rate, and product selectivity. Here, the Pd‐catalyzed p‐nitrothiophenol (PNTP) to p‐aminothiophenol (PATP) hydrogenation and the surface plasmon resonance (SPR) mediated p‐aminothiophenol (PATP) to p,p‐dimercaptoazobenzene (DMAB) oxidation catalytic activities over TiO2‐supported AgAu/Pd NPs (AgAu/Pd/TiO2) are investigated as a function of the Ag to Au ratio using in situ SERS. The results showed that as the PNTP hydrogenation rates grew exponentially with decreased Ag mole fraction, the yield of the PATP to DMAB conversion rapidly diminishes in the opposite trend. The observed variations in catalytic performance can be explained by the formation of surface Ag oxides in Ag‐containing substrates, leading to the inhibition of PNTP catalytic hydrogenation on Ag/Pd/TiO2 while favoring the PATP to DMAB oxidation. This work provides a concrete example of how oxidized Ag can significantly affect the catalytic activity of bifunctional substrates and can guide the rational design of SERS‐active catalysts.