bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of commercial beverages on the neurobehavioral motility of Caenorhabditis elegans
Authors: Zhang Wenjing , Zhang Nan , Zheng Shan , Zhang Wei , Liu Jingjing , He Liwei , Ezemaduka Anastasia Ngozi , Li Guojun , Ning Junyu , Xian Bo , Gao Shan 
Published: July 2022

To study the effects of different types of commercially available drinks/beverages on neurobehavior using the model organism C. elegans, and critically review their potential health hazards. Eighteen kinds of beverages from the supermarket were randomly selected and grouped into seven categories namely functional beverage, tea beverage, plant protein beverage, fruit juice beverage, dairy beverage, carbonated beverage and coffee beverage. The pH value, specific gravity and osmotic pressure were also examined. The L4 stage N2 worms were exposed to different concentration of tested beverages (0, 62.5, 125, 250 and 500 µL/mL) for 24 h to measure the survival rate and locomotory behavior such as head thrashing, body bending as well as pharyngeal pumping. All the 18 beverages tested did not induce any visible lethal effects in the nematodes. However, exposure to different types of tested beverages exhibited different effects on the behavioral ability of C. elegans: (1) sports functional beverage and herbal tea drink accelerated the head thrashing and body bending of nematodes when compared to the control group (P < 0.05). (2) The vibration frequency of the pharyngeal pump of nematodes was significantly accelerated after treated with three plant protein beverages (almond milk, coconut milk and milk tea) and dairy products A and B (P < 0.05), and decelerated after treatment with other tested beverages. (3) Carbonated beverage significantly inhibits the head thrashing, body bending and pharyngeal pumping vibration (P < 0.05). Our results indicate that 18 kinds of popular beverages in the market have different influence on the neurobehavior in C. elegans, which may be related to their different components or properties. Further research would be required to conduct a systematic analysis of the effect of beverages by appropriate kinds, taking into consideration other endpoints such as reproduction, lifespan and molecular stress response, etc., and to elucidate the mechanism for its potential health hazards.
Effects of S-Amlodipine in the Management of Hypertension in Mongolian Patients
Authors: Maladkar Manish , Amarsanaa Javzankhuu , Sengeragchaa Orgil , Patil Shrikant , Anchan Namita 
Published: July 2022

Objective: To evaluate the efficacy and safety of S-Amlodipine in patients suffering from hypertension.
Materials and Methods: A multicenter, prospective, open-label, non-comparative, clinical trial was conducted on 364 patients with hypertension in Mongolia. All these patients were treated with S- Amlodipine 2.5 mg or 5 mg orally once daily for a duration of 8 weeks.
Results: S-Amlodipine treatment resulted in a considerable drop in blood pressure from baseline. After 8 weeks of treatment, the mean systolic blood pressure had decreased by 12.06 mmHg and the mean diastolic blood pressure had decreased by 8.77 mmHg. Furthermore, both physicians and patients assessed the overall efficacy and rated it as good. Also, during the therapy period, 6 individuals (1.7%) experienced minor or slight adverse symptoms such as cough and headache.
Conclusion: The current study confirms that treatment with S-Amlodipine was effective and well-tolerated in the management of hypertension.
Determination of Soil Parameters and Pulling Force Requirement of Tapioca Root
Authors: Chakravarthi N. L. Kalyan , Jayan P. R. 
Published: July 2022

Aims: This paper aims to explore the soil parameters and pulling force requirement of tapioca root for the design and development of tractor operated tapioca harvester.
Place and Duration of Study: The study was conducted to investigate the soil parameters and pulling force requirement of tapioca roots at farmer’s field in the year 2021-22.
Methodology: The soil parameters viz. moisture content, bulk density, cone index and shear strength and pulling force requirement of tapioca root were studied using standard test procedure that plays an important role in design of soil engaging components and conveying unit of the tuber harvester.
Results: The results showed that soil moisture content varied from 13.11 to 16.08 per cent, whereas bulk density ranged from 1483.07 to 1729.56 kg m-3. The cone index varied from 0.33 to 0.98 N mm-2 with an average value of 0.637 N mm-2 and shear strength ranged from 1.34 × 10-3 to 3.48 × 10-3 N mm-2 with the mean value of 2.46 × 10-3 N mm-2. The average value of pulling force requirement for tapioca roots was 103.4 kgf. The root depth and root yield per plant of tapioca roots has an average value of 250.30 mm and 7.82 kg.
Conclusion: The study shows that bulk density of soil increased with increase in soil moisture content and had a linear relationship. The coefficient of determination (R2) for the regression model was 93.20 per cent by revealing the linear relationship between shear strength and cone index. Thus shear strength and cone index are related with each other and have an indefinite effect on the design parameters of soil engaging components of tuber harvester.
Line × Tester Analysis and Estimating Combining Abilities for Yield and Some Quality Attributes in Tomato (Solanum lycopersicum L.)
Authors: Singh Navneet , Ram C. N. , Singh Vikash , Kumar Dijendra 
Published: July 2022

General and specific combining ability (GCA & SCA) for yield and quality traits in tomato were studied by involving fourteen parental line were crossed in line x tester mating design comprising eleven line and three tester at M.E.S department of vegetable science ANDUAT, Ayodhya to estimate combining ability in tomato for fruit yield and quality traits. Combining ability analysis revealed that both additive and non-additive gene action for most of the characteristics and heterosis breeding for the improvement of these traits have been enhanced. Based on GCA effects of parents, the line NDT-4 and the testers Kashi chayan were identified as the best general combiner for yield and its important component. The crosses NDT-2×Arka vikash superior specific combiners for fruit yield per plant.
Effect of the Phosphorus and Sulphur Levels on Growth and Yield of Mustard (Brassica juncea L.) Crop under Rainfed Condition
Authors: Patel Veerendra Kumar , Mishra U. S. , Singh Vivek Kumar 
Published: July 2022

Background: Phosphorus has been pointed out as one of most important in oilseed crop wich is responsible for vegetative growth,reproduction and consequently yield of mustard. Sulphur element is important for crop growth and development especially in oilseed. At present, 42% of Indian soil have been found to the sulphur deficient, sulphur is essential for synthesis of oil percentage, protein, vitamins, in oilseed crops.
Methods: The field investigation was carried out at the Rajaula Research Farm, Faculty of Agricultural Science ,Mahatma Gandhi Chitrakoot Gramodaya Vishwavidyalay, Chitrakoot- Satna (M.P.) during Ravi season 2019-20. The treatment comprised three levels of phosphorus and three levels of sulphur along with absolute control.
Result: The result revealed that application of 30kg phosphorus/ha significantly increase the plant height , plant leaves, primary branches, secondary branches and yield indices vis number of siliqua/plant, number of seed/siliqua, 1000 seed weigh and seed yield than 20kg phosphrus/ha and 0kg phosphorus/ha . Sulphur levels also hed significantly influereced on these growth and yield indices and reconded higher values 20kg sulphur/ha found at per 10kg sulphur/ha and significantly higher over 0kh sulphur/ha. The finding that application of 30kg phosphorus with 20kg sulphur/ha proved the most optimum and beneficial fertility management for the Pusa Mahak veriety mustard for the Bundelkhand/ chitrakoot region of M.P.
Minimal Impact of the COVID‐19 Pandemic on Disease Activity and Health‐Related Quality of Life in Patients With Ankylosing Spondylitis Receiving Bimekizumab: Exploratory Analyses From a Phase 2b Open‐Label Extension Study
Authors: Robinson Philip C. , Machado Pedro M. , Haroon Nigil , Gensler Lianne S. , Reveille John D. , Taieb Vanessa , Vaux Thomas , Fleurinck Carmen , Oortgiesen Marga , de Peyrecave Natasha , Deodhar Atul 
Published: July 2022

ObjectiveThe impact of the COVID‐19 pandemic on patients with inflammatory rheumatic diseases, such as ankylosing spondylitis (AS), has been variable. Here, we assess disease activity and health‐related quality of life (HRQoL) through the pandemic in patients with AS.MethodsIn the open‐label extension (OLE) of the phase 2b BE AGILE study, patients with AS received 160 mg of subcutaneous bimekizumab every 4 weeks. We assessed Ankylosing Spondylitis Disease Activity Score with C‐reactive protein (ASDAS‐CRP), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Quality of Life (ASQoL) scores in the OLE immediately before and during the COVID‐19 pandemic (September 2019 to April 2021).ResultsA total of 232 patients remained in the BE AGILE OLE and were included in this post hoc study at the start of the analysis period (September 1, 2019); 12 patients had a COVID‐19 treatment‐emergent adverse event, and no cases resulted in death. The number of missed bimekizumab doses due to COVID‐19 (11 doses) was minimal, and missed assessments remained low (≤5%) compared with the prepandemic period. Mean ASDAS‐CRP (1.8), BASDAI (2.4), and ASQoL scores (2.8) in the OLE were low at pre‐pandemic baseline and remained stable at 1.7 to 1.8, 2.2 to 2.4, and 2.0 to 2.8, respectively, across successive 3‐month periods immediately before and during the pandemic. ASDAS‐CRP, BASDAI, and ASQoL stability was consistent across major study countries.ConclusionDisease activity and HRQoL remained stable during the COVID‐19 pandemic in patients with AS receiving bimekizumab in the BE AGILE OLE, with no indication of negative effects on these outcomes.
Biointerface Engineering with Nucleic Acid Materials for Biosensing Applications
Authors: Shi Shi , Chen Jing , Wang Xiwei , Xiao Mingshu , Chandrasekaran Arun Richard , Li Li , Yi Chengqing , Pei Hao 
Published: July 2022

AbstractMolecular recognition at the biointerface plays a critical role in sensing molecular interactions (e.g., DNA hybridization) and extracellular changes, which can directly affect the detection performance of biosensors (e.g., sensitivity, specificity, and response dynamics). However, conventional sensing biointerfaces show low molecular recognition efficiency due to limited target accessibility. Engineering sensing biointerfaces to regulate the orientation, spacing, and density of surface‐confined molecular probes offer an effective approach to improve molecular recognition at interfaces. Over the last decades, biointerface engineering with nucleic acid materials has advanced the fundamental understanding of DNA hybridization kinetics and facilitated the design of improved biosensing platforms for monitoring cellular activities and diagnosing relevant diseases. This review summarizes the recent progress in nucleic acid‐based biointerface engineering. The development of nucleic acid materials that can be applied to specific diagnostic applications is briefly introduced. Then the roles of nucleic acids in tailoring the properties of nanosurfaces, cell surfaces, and macroscopic surfaces are discussed and their biosensing applications are comprehensively highlighted. Finally, future challenges and perspectives of emerging technologies and applications in the field are presented.
Injectable, Self‐healing, and 3D Printable Dynamic Hydrogels
Authors: Lee Hung Pang , Deo Kaivalya A. , Jeong Jinwoo , Namkoong Myeong , Kuan Kai Yuan , Tian Limei , Gaharwar Akhilesh K. 
Published: July 2022

AbstractDynamic hydrogels are promising biomaterials for various biomedical and biotechnological applications due to their ability to change physicochemical properties and functions reversibly and/or sequentially in a time‐ or stimuli‐dependent manner. In this study, a new class of dynamic hydrogels that are crosslinked by the in situ redox reactions of gold ions and disulfide groups are developed. Specifically, the gold ions initiate hydrogel formation via gold‐thiol crosslinking, transforming the hydrogel from an injectable hydrogel to a mechanically stable and tough hydrogel. Moreover, the in situ nucleation and growth of gold nanoparticles within the crosslinked hydrogel networks further enhance electrical conductivity. The current work demonstrates the utility of these dynamic hydrogels for 3D printing and drug delivery.
Size‐Dependent Photon Avalanching in Tm3+ Doped LiYF4 Nano, Micro, and Bulk Crystals
Authors: Dudek Magdalena , Szalkowski Marcin , Misiak Małgorzata , Ćwierzona Maciej , Skripka Artiom , Korczak Zuzanna , Piątkowski Dawid , Woźniak Piotr , Lisiecki Radosław , Goldner Philippe , Maćkowski Sebastian , Chan Emory M. , Schuck P. James , Bednarkiewicz Artur 
Published: July 2022

AbstractPhoton avalanche (PA) is a highly nonlinear mode of upconversion that is characterized by 100–1000‐fold increase in luminescence intensity upon minute increments of pumping power. The practical realization of numerous possible nano‐bio‐technology applications utilizing the PA phenomenon will require information on its susceptibility to the material volume and surface. Here, these parameters are investigated via experimental and theoretical PA. The two‐color, highly nonlinear PA emission at 475 and 800 nm is clearly observed in bulk single crystal, individual microcrystals, and ensembles of colloidal core and core–shell nanoparticles of LiYF4 host doped with either 3 or 8% of thulium ions. The properties of PA emission, such as PA nonlinearity, PA gain, PA intensity, and luminescence kinetics in these materials show dependence on crystal volume and surface quenching. Theoretical simulations provide understanding of key physical processes that influence PA performance. Moreover, photon avalanche single beam super‐resolution imaging is realized for the first time in 3% Tm3+ doped LiYF4 core–shell nanoparticles. The obtained insights and predictions form a solid background for further development and applications of new optimized PA materials.
Deep‐Blue Light‐Emitting Diodes Constructed with Perovskite Quasi‐2D and Nanocrystal Mixtures
Authors: Pang Peiyuan , Xing Zhaohui , Xia Junmin , Wang Bingzhe , Zhang Zhipeng , Guo Jia , Liu Tanghao , He Bingchen , Chen Jiangshan , Chen Shi , Xing Guichuan 
Published: July 2022

AbstractIn the past several years, metal‐halide perovskites have attracted much attention for their promising applications in light‐emitting diodes (LEDs). Significant progress has been made in the development of high‐efficiency green, red, and near‐infrared perovskite LEDs (PeLEDs), but blue PeLEDs are still lagging behind. Although the external quantum efficiency (EQE) of blue PeLEDs has exceeded 10%, these works mainly focus on pure blue and sky‐blue regions. Creating deep‐blue electroluminescence (EL) with high stability, efficiency, and color purity is still a great challenge for PeLEDs. Herein, deep‐blue PeLEDs are reported which have been constructed with a mixture of a quasi‐2D phase and a nanocrystal phase by introducing a small diamine cation, ethylene diammonium (EDA2+), and the effect of EDA2+ on quasi‐2D perovskite crystallization is investigated. EDA2+ with two amino ending groups has a stronger inhibitory effect on high‐n phase growth than phenylethyl ammonium, leading to the formation of small nanocrystals. Further introduction of Na+ reduces the size of the nanocrystals and broadens the band gap. Based on these improvements, deep‐blue PeLEDs with EL peaks at 467 (EQE ≈ 1.7%) and 461 nm (EQE ≈ 1.1%) are successfully constructed. Thus, this study provides a useful strategy for improving the performance of deep‐blue PeLEDs.
Reversible Charge‐Polarity Control for Multioperation‐Mode Transistors Based on van der Waals Heterostructures
Authors: Chen Ciao‐Fen , Yang Shih‐Hsien , Lin Che‐Yi , Lee Mu‐Pai , Tsai Meng‐Yu , Yang Feng‐Shou , Chang Yuan‐Ming , Li Mengjiao , Lee Ko‐Chun , Ueno Keiji , Shi Yumeng , Lien Chen‐Hsin , Wu Wen‐Wei , Chiu Po‐Wen , Li Wenwu , Lo Shun‐Tsung , Lin Yen‐Fu 
Published: July 2022

AbstractVan der Waals (vdW) heterostructures—in which layered materials are purposely selected to assemble with each other—allow unusual properties and different phenomena to be combined and multifunctional electronics to be created, opening a new chapter for the spread of internet‐of‐things applications. Here, an O2‐ultrasensitive MoTe2 material and an O2‐insensitive SnS2 material are integrated to form a vdW heterostructure, allowing the realization of charge‐polarity control for multioperation‐mode transistors through a simple and effective rapid thermal annealing strategy under dry‐air and vacuum conditions. The charge‐polarity control (i.e., doping and de‐doping processes), which arises owing to the interaction between O2 adsorption/desorption and tellurium defects at the MoTe2 surface, means that the MoTe2/SnS2 heterostructure transistors can reversibly change between unipolar, ambipolar, and anti‐ambipolar transfer characteristics. Based on the dynamic control of the charge‐polarity properties, an inverter, output polarity controllable amplifier, p‐n diode, and ternary‐state logics (NMIN and NMAX gates) are demonstrated, which inspire the development of reversibly multifunctional devices and indicates the potential of 2D materials.
Hydrogen Tunneling in Catalytic Hydrolysis and Alcoholysis of Silanes
Authors: Almenara Naroa , Garralda Maria A. , Lopez Xabier , Matxain Jon M. , Freixa Zoraida , Huertos Miguel A. 
Published: July 2022

AbstractAn unprecedented quantum tunneling effect has been observed in catalytic Si−H bond activations at room temperature. The cationic hydrido‐silyl‐iridium(III) complex, {Ir[SiMe(o‐C6H4SMe)2](H)(PPh3)(THF)}[BArF4], has proven to be a highly efficient catalyst for the hydrolysis and the alcoholysis of organosilanes. When triethylsilane was used as a substrate, the system revealed the largest kinetic isotopic effect (KIESi−H/Si−D=346±4) ever reported for this type of reaction. This unexpectedly high KIE, measured at room temperature, together with the calculated Arrhenius preexponential factor ratio (AH/AD=0.0004) and difference in the observed activation energy [(E
−E
)=34.07 kJ mol−1] are consistent with the participation of quantum tunneling in the catalytic process. DFT calculations have been used to unravel the reaction pathway and identify the rate‐determining step. Aditionally, isotopic effects were considered by different methods, and tunneling effects have been calculated to be crucial in the process.
Aufklärung der CO2‐Hydrierung über In2O3‐Nanopartikeln mittels Operando UV/Vis‐ und Impedanzspektroskopie
Authors: Ziemba Marc , Radtke Mariusz , Schumacher Leon , Hess Christian 
Published: July 2022

AbstractWährend sich In2O3 als vielversprechender Katalysator für die CO2‐Aktivierung erwiesen hat, fehlt bisher ein grundlegendes Verständnis seiner Funktionsweise bei der CO2‐Hydrierung, da die Anwendung der operando‐Schwingungsspektroskopie aufgrund von Absorptionseffekten eine Herausforderung darstellt. In dieser mechanistischen Studie untersuchen wir systematisch die Redox‐Prozesse im Zusammenhang mit der reversen Wassergas‐shift‐Reaktion (rWGSR) über In2O3‐Nanopartikeln, sowohl an der Oberfläche als auch in der Bulkstruktur. Basierend auf temperaturabhängigen operando‐UV/Vis‐Spektren und einem neuartigen operando‐Impedanz‐Ansatz für thermische Pulverkatalysatoren schlagen wir die Oxidation durch CO2 als den geschwindigkeitsbestimmenden Schritt für die rWGSR vor. Die Ergebnisse stimmen mit Redox‐Prozessen überein, wobei wasserstoffhaltige Oberflächenspezies nachweislich eine fördernde Wirkung aufweisen. Unsere Ergebnisse zeigen, dass für die Aktivität neben Oberflächenprozessen die Sauerstoff/Wasserstoff‐Dynamik wichtig ist, was nicht nur für In2O3, sondern auch für andere reduzierbare Oxidkatalysatoren von Bedeutung sein dürfte.
(4+3) Annulation of Donor‐Acceptor Cyclopropanes and Azadienes: Highly Stereoselective Synthesis of Azepanones
Authors: Nicolai Stefano , Waser Jérôme 
Published: July 2022

AbstractAzepanes are important seven‐membered heterocycles, which are present in numerous natural and synthetic compounds. However, the development of convergent synthetic methods to access them remains challenging. Herein, we report the Lewis acid catalyzed (4+3) annulative addition of aryl and amino donor‐acceptor cyclopropanes with 2‐aza‐1,3‐dienes. Densely substituted azepane derivatives were obtained in good to excellent yields and with high diastereoselectivity. The reaction occurred under mild conditions with ytterbium triflate as the catalyst. The use of copper triflate with a trisoxazoline (Tox) ligand led to an enantioselective transformation. The obtained cycloadducts were convenient substrates for a series of further modifications, showing the synthetic utility of these compounds.
Multienzyme Redox System with Cofactor Regeneration for Cyclic Deracemization of Sulfoxides
Authors: Peng Tao , Tian Jin , Zhao Yuyan , Jiang Xu , Cheng Xiaoling , Deng Guozhong , Zhang Quan , Wang Zhongqiang , Yang Jiawei , Chen Yongzheng 
Published: July 2022

AbstractOptically pure sulfoxides are noteworthy compounds applied in a wide range of industrial fields; however, the biocatalytic deracemization of racemic sulfoxides is challenging. Herein, a high‐enantioselective methionine sulfoxide reductase A (MsrA) was combined with a low‐enantioselective styrene monooxygenase (SMO) for the cyclic deracemization of sulfoxides. Enantiopure sulfoxides were obtained in >90 % yield and with >90 % enantiomeric excess (ee) through dynamic “selective reduction and non‐selective oxidation” cycles. The cofactors of MsrA and SMO were subsequently regenerated by the cascade catalysis of three auxiliary enzymes through the consumption of low‐cost D‐glucose. Moreover, this “one‐pot, one‐step” cyclic deracemization strategy exhibited a wide substrate scope toward various aromatic, heteroaromatic, alkyl and thio‐alkyl sulfoxides. This system proposed an efficient strategy for the green synthesis of chiral sulfoxide.
Structural and luminescence studies of titanium co‐doped SrY2O4:Eu phosphors
Authors: Bhatia Smriti , Priya Ruby , Kumar Dinesh , Upadhyay Sanjay , Pandey Om Prakash 
Published: July 2022

AbstractHere, europium‐doped (1 to 11 mol%) and titanium (1 to 5 mol%)co‐doped SrY2O4:Eu phosphors were synthesized using solid‐state reaction method. The synthesized samples were characterized using X‐ray diffraction (XRD), field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FTIR), and photoluminescence (PL) techniques for structural, morphological, functional group, and photoluminescence studies, respectively. XRD patterns confirmed the formation of pure phase SrY2O4 at 1300°C and structural parameters were further determined using Rietveld refinement. FESEM micrographs revealed that doped and co‐doped samples had different morphological features. All the samples were excited at ultraviolet light excitation and emission spectra consisted of peaks corresponding to the Eu ions. The maximum PL intensity was observed for 9 mol% of Eu ions and 3 mol% co‐doping of Ti ions. The synthesized phosphors have potential applications in optoelectronics and display devices.