bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation study between sagittalization of lumbar facet joints and lumbar intervertebral disc degeneration: a retrospective analysis
Authors: Huang Leitao , Shi Zongpo , Yang Kaixiang , Chen Ji , Zhang Chen , Bi Lei , Qi Lei , Zhang Bin , Wang Boyao 
Published: May 2022

Abstract
Purpose: To investigate the correlation between sagittalization of lumbar facet joints and lumbar intervertebral disc degeneration (IVDD). Methods: Seventy-five patients with low back pain and forty healthy volunteers (control) underwent standard MRI protocols. The basic information of all patients, including age, gender, body mass index, was collected, and the lumbar facet joint angle (LFJA) was measured on lumbar magnetic resonance imaging (MRI), and the lumbar IVDD was assessed by Pfirrmann grading. All data were analyzed statistically. Results: Compared with the control group, the LFJA of L3/4, L4/5 and L5/S1 in the patient group were significantly decreased, and there was a statistical difference (P < 0.05). The lower the segment, the more significant the sagittalization of the facet joints (P < 0.05). In the patient group, there was a statistically significant difference in the LFJA between the Pfirrmann grades of lumbar IVDD, and there was a strong negative correlation (ρ=-0.736, P < 0.05). Conclusion: With the increase of the sagittal degree of LFJA, the IVDD also increases significantly, and this relationship has a strong negative correlation. It is indicated that the sagittalization of facet joints can be an important pathological change of lumbar IVDD. The LFJA is a very good predictor for evaluating lumbar IVDD.
LPS Induced Coagulation and Neuronal Damage in a Mice Model is Attenuated by Enoxaparin
Authors: Berkowitz Shani , Gofrit Shany Guly , Aharoni Shay Anat , Golderman Valery , Qassim Lamis , Goldberg Zehavit , Dori Amir , Maggio Nicola , Chapman Joab , Shavit-Stein Efrat 
Published: May 2022

Abstract
Neuroinflammation and coagulation interact, therefore, the neural effects of lipopolysaccharide (LPS)-induced inflammation (1 mg/kg, intraperitoneal (IP), n = 20) and enoxaparin treatment (1 mg/kg, IP, 15 minutes, and 12 hours following LPS, n = 20) were studied in C57BL/6J mice. One week after LPS injection, sensory, motor, and cognitive functions were assessed by a hot plate, rotarod, Open-Field test (OFT), and Y-maze. We measured thrombin activity with a fluorometric assay, hippocampal mRNA expression of coagulation and inflammation factors by real-time- PCR and serum neurofilament-light-chain (NfL), and tumor necrosis factor-α (TNF-α) by a single-molecule array (Simoa) assay. Reduced crossing center frequency was observed in both LPS groups in the OFT (p = 0.02) along with a minor motor deficit between controls and LPS indicated by the rotarod (p = 0.057). Increased hippocampal thrombin activity (p = 0.038), and protease-activated receptor 1 (PAR1) mRNA (p = 0.01) were measured in LPS compared to controls but not in enoxaparin LPS treated mice (p = 0.4, p = 0.9, respectively). Serum NfL and TNF-α levels were elevated in LPS mice (p < 0.05) and normalized by enoxaparin treatment. These results indicate that inflammation, coagulation, neuronal structure, and function are linked and may regulate each other, suggesting another pharmacological mechanism for intervention in neuroinflammation.
Association of TPA 25 gene with UrinaryTract Infection (UTI)in the tribal population of DimapurDistrict, Nagaland, India
Authors: Thisa Vecülü , Ao Semsadangla , Singson Moanaro , Kiewhuo Magdalene , Ganesan Ramesh , Rangasamy Nandakumar 
Published: May 2022

Abstract
Urinary tract infections(UTI) are the most common problem caused by infections in the urinary system, which includes kidneys, bladder, ureters and urethra. Urinary infections are found to be one of the common diseases worldwide. The study mainly focuses on analyzing the association of TPA 25 gene with Urinary tract infected individual in tribal population of Dimapur District. This study considers the population of Urinary tract infection(UTI)patients. The samples of the study consist of 32 Urinary tract infected patient which was collected from Eden hospital, Dimapur and 32 control samples through random sampling technique. The genotyping is done using Polymerase Chain Reaction (PCR) with allele specific marker (TPA 25). The study concluded that the association of TPA gene is significantly high in both ID and DD genotype (0.00*) of the male population and females shows statistical significant in ID and II phenotype (0.002*).
Photobiomodulation: a promising innovative approach for preventing oral mucositis in patients undergoing hematopoietic stem cell transplantation
Authors: Stocker Nicolas , Baltes Virginie , Bellaiche Solal , Brouillard Flora , Belmoufid Nadia , Rousseau Céline , Bonnin Agnès , de Wyngaert Zoé Van , Ricard Laure , Banet Anne , Malard Florent , Dulery Remy , Mohty Mohamad , Brissot Eolia 
Published: May 2022

Abstract
Purpose: The study aims to investigate the efficacy/acceptance of photobiomodulation by a quick and easy-to-use device for both preventing oral mucositis (OM) and reducing its severity in the setting of hematopoietic stem cell transplantation (HCT).Methods: Twenty-five consecutive patients underwent autologous HCT for hematological malignancies between November 2020 and October 2021. Prophylactic photobiomodulation (PBM) was used daily from day 1 of conditioning until the day of neutrophil recovery at a dose of 3 J/cm2. Curative PBM was started at a dose of 6 J/cm2 when at least one grade 1 OM had occurred. For each OM case, time of onset, National Cancer Institute-Common Terminology Criteria for Adverse Events (NCI-CTCAE) v5.0 grade for OM, analgesic dose, and time to resolution were reported.Results: The median age of the 25 patients was 58 years (range, 39-74) and 14 (56%) were male. Twenty-one patients (84%) received a high dose melphalan conditioning regimen for multiple myeloma, and 4 (16%) patients received BEAM conditioning for aggressive lymphoma. A total of 178 CareMin650 sessions were performed, with a median of 7 days of application (range, 4-12), with no device-related adverse events (AEs). According to the NCI-CTCAE v5.0 scale, 76% (19 of 25) of patients presented grade 0 or 1 mucositis (no ulcers), five patients (20%) developed small ulcers (grade 2), and only one patient developed grade 4 mucositis. Satisfaction rates were high among patients and users.Conclusion: Photobiomodulation provides excellent safety and tolerance, as well as promising efficacy, both as a preventive and curative strategy, in patients undergoing autologous HCT.
Support for mask use as a COVID-19 public health prevention measure among a large sample of Canadian secondary school students
Authors: Patte Karen A. , Wade Terrance J , MacNeil Adam J , Bélanger Richard E. , Duncan Markus J , Riazi Negin , Leatherdale Scott T. 
Published: May 2022

Abstract
Objectives: We examined the level of student support of mask use in public spaces and school mask requirements intended to prevent SARS-CoV-2 transmission, as well as factors associated with students’ perspectives.
Methods: We used cross-sectional survey data from 42,767 adolescents attending 133 Canadian secondary schools that participated in the COMPASS study during the 2020/2021 school year. Multinomial regression models assessed support for i) wearing a mask in indoor public spaces and ii) schools requiring students to wear masks, in association with COVID-19 knowledge, concerns, and perceived risk.
Results : Wearing masks in indoor public spaces was supported by 81.9% of students; 8.7% were unsupportive and 9.4% were neutral/undecided. School mask requirements were supported by 67.8%, with 23.1% neutral and 9.1% unsupportive. More females supported mask wearing in public spaces (83.9% vs. 79.1%) and school mask requirements (70.8% vs. 63.5%) than males. Students had increased odds of supporting mask use in public spaces and school mask requirements if they reported concerns about their own or their family’s health, had discussions regarding ways to prevent infection, perceived COVID-19 to be a risk to young people, and knew that signs are not always present in COVID-19 cases and that masks prevent SARS-CoV-2 transmission if someone coughs.
Conclusions : During the year following the beginning of the pandemic, most students supported wearing masks in indoor public spaces and the required use of masks in schools. Improving knowledge around the effectiveness of masks appears likely to have the largest impact on mask support among adolescent populations.
Evapotranspiration, crop coefficient and water consumption of pulse-irrigated bell peppers at different growing seasons
Authors: Silva Thaís Rayane Gomes , Santos Samuel Barbosa Tavares dos , Santos Márcio Aurélio Lins dos , Santos Cícero Gomes dos , Silva Gerônimo Ferreira da , Santos Marcos Alex dos , Bubans Valéria Escaio 
Published: May 2022

Abstract
Pulse irrigation is among the techniques used to improve the efficiency of water management, consisting of the fractional application of the actual irrigation needed. Seeking to maximize the use of water in agricultural production, the objective was to determine the water consumption of bell peppers through the crop coefficient, crop evapotranspiration and pulse-irrigated reference evapotranspiration, at different growing seasons. The experiments were carried out from January to March, May to July and August to October, with the installation of 25 drainage lysimeters, distributed along five planting rows. The crop coefficient obtained for each irrigation pulse was determined through the ratio between the crop evapotranspiration and the reference evapotranspiration. Crop evapotranspiration was obtained daily for each irrigation pulse, determined by the difference between an applied and a drained depth. The reference evapotranspiration was estimated using the Penman-Monteith, Hargreaves-Samani, Solar Radiation, Blaney-Criddle and Priestley-Taylor methods. The Penman-Monteith method showed higher reference evapotranspiration when compared to the other estimation methods. Crop evapotranspiration was lower in the continuous pulse, due to the availability of water for the plant to be applied in the total irrigation time. Thus, the lowest water consumption obtained in pulse 1 and the higher obtained in pulse 5, in all seasons. Evidencing that the addition of irrigation pulses provided the best use of water by the crop. This study demonstrates the importance of optimizind the use of water in irrigated agriculture, helping technicians and producers in decision making.
Task-shifting and family planning continuation: contraceptive trajectories of women who received their method at a community-based event in Kinshasa, DRC
Authors: Hernandez Julie H. , LaNasa Katherine H. , Koba Tesky 
Published: May 2022

Abstract
While community-based interventions are a proven high-impact strategy to increase contraceptive uptake in low-income countries, their capacity to support sustained use of family planning remains insufficiently discussed. This cohort study follows 883 women 3 and 6 months after they received a modern method during community campaigns organized in Kinshasa (D.R. Congo), to analyze their contraceptive trajectories (continuation, switching, abandonment) and the factors associated with ever discontinuing contraceptive use in the first six months following a campaign. Contrary to most pilot studies, campaign clients were not provided with additional support, besides baseline counseling, to continue using the method they received, and could only rely on resources of the existing local health system. Almost a third (28.9%) of all women discontinued using modern contraception during the study period, with much higher discontinuation rates for short-acting methods (29.8% for pills and up to 64.0% for DMPA-SC). Variables previously associated with high discontinuation (marital status, fertility intentions and side-effects) led to higher OR for “ever discontinuing”. However, these variables became non-significant when controlling for resupply issues. Women’s self-reported reasons for discontinuation confirmed the multivariate regression results. Detailed sub-analysis of resupply issues for short-acting methods highlighted the role of cost, unreliable campaign schedules and weak integration of community-based strategies into the formal health system, which hinders their capacity to act as a gateway into long-term contraceptive use.
Continuous Liquid Metal Printed 2D TCO Superlattices
Authors: Ye Youxiong , Hamlin Andrew B. , Huddy Julia E. , Rahman Md Saifur , Scheideler William J. 
Published: May 2022

Abstract
2D conducting metal oxides offer unprecedented control of thin film electrostatics at the nanoscale. We present a scalable, rapid, and low-cost approach to printing transparent conductive oxides (TCOs) via spontaneous low-temperature Cabrera-Mott oxidation of compliant liquid metals. We exploit repeating heterostructures of these 2D oxides for achieving defect modulation doping – to produce exceptional, 100X increase in conductivity while simultaneously raising the optical transmittance. This innovative approach employs nanoscale remote electron donation at the type I heterojunction between InOx / GaOx, exceeding the achievable performance with ITO, which is otherwise limited by poor dopant activation at low temperatures. The exceptional performance of these multilayer 2D TCO superlattices exceeds that of competing TCOs printed from sol-gels and nanoparticles, establishing a 100X faster process to fabricate flexible inorganic electronics.
ChAdOx1-S and BBV152 vaccines – Effectiveness on post-vaccination and COVID-19 outcomes.
Authors: Agrawal Ruchi , Agrawal Yogesh , Mathur Shikha , Singh Yogesh , Tak Amit 
Published: May 2022

Abstract
Background
ChAdOx1-S (vaccine A) and BBV152 (vaccine B) vaccines are currently at the forefront of India’s fight against the pandemic. The present study tests the hypothesis that both vaccines are equally efficacious.
Material and Methods
This cross-sectional study was conducted at MGM Hospital, Jaipur (Rajasthan, India). The study compared vaccine A and B recipients on post-vaccination events and COVID-19 related outcomes. Researchers collected data using questionnaires circulated through Google Forms. The association between attributes was tested using the chi-squared test. The significance level was considered at 5%.
Results
The vaccines A and B recipients were age and gender-matched [p > 0.05]. The vaccines did not differ significantly in vaccine events and adverse events after immunization (p > 0.05). A comparison of COVID-19 related outcomes between the two vaccines revealed no significant differences (p > 0.05). However, the severity of symptoms was higher in vaccine B recipients than in vaccine A recipients [p = 0.027].
Conclusion
The present study concludes that vaccines A and B were similar in efficacy. The most crucial factor revealed by the survey is that the reporting of adverse events was significantly less, and awareness is needed.
Integrative metatranscriptomic analysis reveals disease-specific microbiome-host interactions in oral squamous cell carcinoma
Authors: Jain Vinay , Baraniya Divyashari , Chen Tsute , Slifker Michael , Alakwaa Fadhl , Cai Kathy , Chitrala Kumaraswamy , Fundakowski Christopher , Al-hebshi Nezar 
Published: May 2022

Abstract
Studies on the microbiome of oral squamous cell carcinoma (OSCC) have been largely limited to 16S rRNA gene sequencing. Here, we used laser microdissection coupled with metatranscriptome sequencing at unprecedented depth (~ 400 million sequences/sample) to simultaneously characterize the multi-kingdom microbiome and host transcriptomes and predict their interaction in OSCC. Analysis was performed on 20 HPV16/18-negative OSCC tumor/adjacent normal tissue pairs (TT and ANT) along with deep tongue scrapings from 20 matched healthy controls (HC). A range of bioinformatic tools coupled with in-house algorithms were used to map, analyze, and integrate microbial and host data. Analysis of the host transcriptome identified enrichment of known cancer-related gene sets (proliferation, apoptosis inflammation, angiogenesis and invasion/metastasis pathways), not only in the TT group vs. the ANT and HC groups, but also in the ANT vs. HC contrast, consistent with field cancerization. Microbial analysis identified a low abundance yet transcriptionally active, unique multi-kingdom microbiome in OSCC tissues predominated by bacteria and bacteriophages. HC showed a different taxonomic profile yet shared major microbial enzyme classes and pathways with TT/ANT, consistent with functional redundancy. Key taxa enriched in TT/ANT compared to HC were Cutibacterium acnes, Malassezia restricta, Roseolovirus (Human Herpes Virus 6B), Nupapillomavirus, and bacteriophage Yuavirus (predominantly alpha proteobacterium JL001). Functionally, hyaluronate lyase, a hyaluronic acid degrading enzyme produced by C. acnes, was overexpressed in TT/ANT. Integration of microbial and host data revealed that OSCC-associated taxa were associated with upregulation of proliferation-related pathways E2F targets, MYC targets and G2M check point. The study provides a new insight into potential mechanisms by which the microbiome can contribute to oral carcinogenesis, which can be validated in future experimental studies.
An Improved Rational Approximation of Bark Scale using Low Complexity and Low Delay Filter Banks
Authors: V HAREESH , S Bindiya T. 
Published: May 2022

Abstract
This paper proposes an algorithm to obtain the sampling factors to model any frequency partitioning so that it is realized using low complexity rational decimated non-uniform filter banks (RDNUFBs). The proposed algorithm is employed to approximate the Bark scale to find a rational frequency partitioning that can be realized using RDNUFBs with less approximation error. The proposed Bark frequency partitioning is found to reduce the average deviation in center frequency and bandwidth by 65.04% and 48.50% respectively, and root mean square bandwidth deviation by 54.46 % when compared to those of the existing perceptual wavelet approximation of Bark scale.
In the first filter bank design approach discussed in the paper, a near perfect reconstruction partially cosine modulated filter bank is employed to obtain the improved Bark frequency partitioning. In the second design approach, the hardware complexity of the PCM based RDNUFB is reduced by deriving the channels with different sampling factors from the same prototype filter by the method of channel merging. There is a considerable reduction of 40.83 % in the number of multipliers when merging of partially cosine modulated channels is employed. It is also found that both the proposed approaches can reduce the delay by 95.17 % when compared to the existing rational tree approximation methods and hence, are suitable for real time applications.
Treatment Outcome for Adults in a Residential Program for Binge Eating Spectrum Disorders: Protocol for a Prospective Pragmatic Single-Arm Trial
Authors: Rienecke Renee D , Blalock Dan V , Mills Haley D , Duffy Alan , Manwaring Jamie , Le Grange Daniel , Mehler Philip S , McClanahan Susan , Johnson Craig 
Published: May 2022

Background
Most studies reporting treatment outcomes for eating disorders at higher levels of care focus on anorexia nervosa and bulimia nervosa. No studies have been published with a singular focus on examining treatment outcomes for adults receiving residential programming specifically designed for the treatment of binge eating spectrum disorders (BESD), including binge eating disorder and bulimia nervosa.

Objective
The purpose of this paper is to outline the protocol of a prospective study examining treatment outcomes at discharge and 3-month, 6-month, and 12-month postdischarge follow-up, for a sample of consecutive admissions to a residential program specifically for patients with BESD.

Methods
One hundred consecutive admissions to a binge eating treatment program were enrolled in the prospective single-arm trial between January 2019 and February 2020. Data were collected at admission, discharge, and 3, 6, and 12 months postdischarge, with admission, discharge, and 12-month follow-up as the major timepoints of interest. Results across the major timepoints will be analyzed with mixed effects general linear models.

Results
The primary aim is to assess the impact of the program on eating disordered behaviors at discharge and 12-month follow-up, which are hypothesized to improve as a result of treatment. Secondary hypotheses include improvements on comorbid symptoms, including trauma, depression, and obsessive-compulsive symptoms, as well as improvements on medical indicators of health, including cholesterol and triglycerides, at discharge and 12-month follow-up.

Conclusions
This study may aid in the development of treatment guidelines for patients with BESD at higher levels of care and lend support to having specialty treatment programs for patients with BESD.

International Registered Report Identifier (IRRID)
DERR1-10.2196/32270
Perfil epidemiológico de pacientes ortopédicos atendidos na Fisioterapia em um Centro de Reabilitação
Authors: Moraes Lusicleide Galindo da Silva , De Moraes Gois Nascimento Manoela , Da Paz Cardoso dos Santos Thaise 
Published: May 2022

A partir da identificação do perfil epidemiológico através da ocorrência das patologias ortopédicas mais frequentes, o fisioterapeuta pode intervir nas necessidades específicas e individuais. Nesse sentido, o presente estudo teve como objetivos delinear o perfil epidemiológico de pacientes atendidos em um centro especializado de reabilitação da rede SUS; traçar o perfil o sociodemográfico; relacionar as principais patologias que acometem os pacientes por faixa etária e sexo; elaborar uma cartilha de orientações posturais e alongamentos para a patologia ortopédica de maior ocorrência. Tratou-se de uma pesquisa documental de corte transversal, natureza descritiva e de abordagem quantitativa. Foi realizado o levantamento de 271 prontuários de pacientes atendidos no período de janeiro a dezembro de 2019. Destes, baseados nos critérios de inclusão e exclusão, 197 foram selecionados e 74 excluídos. Observou-se que o sexo feminino foi o mais afetado (63,96%), numa faixa de idade entre 52 a 61 anos. O diagnóstico mais presente foi a lombalgia/ lombociatalgia (27,92%) seguida de lesões tendinosas (11,17%). Os resultados dessa pesquisa visam contribuir para que o fisioterapeuta conheça cada vez mais as disfunções preponderantes e o público mais acometido, podendo traçar melhores estratégias para a prevenção e tratamento de patologias ortopédicas.
EFEKTIVITAS PEMBELAJARAN DARING MENGGUNAKAN GOOGLE CLASSROOM TERHADAP MINAT BELAJAR MATEMATIKA PADA SISWA SEKOLAH DASAR
Authors: Damayanti Bella 
Published: May 2022

The aim of this study was to find out the effectiveness of using Google classroom during online learning toward students' elementary Interest in math learning. The study adopt descriptive quantitative Which focus on students' interest during online learning. the partisipant for the study were elementary student on Banten province that were using Google classroom during online learning. The students were choose by Random sampling technique. The instrument to collect the data was using quesioner on google form. Data was analysis by using prosentase uji. The results of the study showed that online learning using google classroom on interest in learning mathematics in elementary school students has been effective. This is indicated by the acquisition of an average score for indicators of interest in learning mathematics using Google Classroom (61%), the use of Google Classroom features (72%) and the effectiveness of online learning using Google Classroom (62%). Although there are still students disagree that online learning is not effective (4.4%).