bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Pulse Current Treatment on Microstructure and Properties of 304 Stainless Steel Ultra-thin Strip after Rolling
Authors: Liu Qi , Fan Wanwan , Ren Zhongkai , Wang Tao , Huang Qingxue 
Published: June 2022

Abstract

The annealing process is usually used to recrystallize the cold-deformed 304 stainless steel ultra-thin strip, but the whole process requires high temperature and long time. Here, we use the method of loading pulse current instead of the traditional annealing process to process the cold-rolled ultra-thin strip. After the cold-rolled sample with a thickness of 0.035 mm and a width of 6mm was loaded with 25 W pulse current for 5 minutes, complete recrystallization occurred. At this time, the measured temperature was only 540℃, and the annealing process at the same temperature and time was used. The microstructure of the sample is still dominated by deformed crystals, and the difference between the two is significant. By studying the microstructure and mechanical properties after treatment, it is found that the pulse current can greatly improve the plastic deformation ability of the cold-rolled ultra-thin strip. The reason is that the electrical effect generated by the pulse current flowing through the sample promotes recrystallization and causes grain refinement. However, the pulse current power has a threshold value. When the loading current power is lower than the threshold value, the effect is not enough to make the sample fully recrystallize. In this range, the area of recrystallization increases with the increase of power, and the fine grain chain is generated from part of the grain boundary area and develops into a large area of recrystallization. When the threshold value is exceeded, the recrystallized grain will grow again, thereby affecting the mechanical properties of the sample. This discovery provides a new idea for the recrystallization process of cold-rolled 304 stainless steel ultra-thin strip.
The Utilization of Bariatric Surgery in Patients with and without Diabetes: Results from the Second Kuwait National Bariatric Surgery Database Report
Authors: Sabah Salman Al , Haddad Eliana Al 
Published: June 2022

Abstract
BackgroundDuring the year 2021, we were able to create the second Kuwait National Bariatric Surgery Database Report, which we used to extract data on the status and outcomes of patients presenting with type 2 diabetes mellitus (T2DM) undergoing bariatric-metabolic surgery in Kuwait. MethodsData was collected from seven public hospitals in Kuwait, and submitted to be merged in the National Registry. Cross-sectional analysis was then conducted. ResultsAll seven hospitals contributed to the submission of data. The rate of T2DM was 12.5% (607 patients), of which 69% were female. The mean age of patients with T2DM was higher than that of patients without (42 years vs 31.9 years). The overall BMI was slightly higher for patients with T2DM (mean 43.4kg/m2 vs 43.1kg/m2). The majority of patients with T2DM were in the BMI range 40.0-49.9kg/m2. Laparoscopic sleeve gastrectomy accounted for 79.0% of all procedures performed in non-diabetic patients and 79.7% of those performed in diabetic patients. When looking at surgical procedure distribution when classified according to starting BMI group in diabetic patients, it was interesting to see that, in Group 1 (BMI <35), sleeve gastrectomy only accounted for 47.2%, while in the larger BMI groups (>35), sleeve gastrectomy accounted for 82.6-83.2% of all procedures performed. When comparing post-op compilations between diabetic vs non-diabetic patients, the percentage of overall complications encountered did not show a significant difference (1.81% vs 2.10% ; p=0.602). When looking at cardiovascular complications, patients with diabetes tended to present with higher post-op cardiac complications compared to non-diabetics (p=0.000).ConclusionLaparoscopic sleeve gastrectomy was the most performed procedure in both diabetics and non diabetics alike. Patients with diabetes tended to present for surgery at an older age than those without. It was interesting, albeit possibly expected, to note that patients with diabetes presented with a higher percentage of a multitude of complications post-operatively, pointing towards the importance of post-operative care in diabetic patients that present for bariatric surgery.
Experimental observation of spin-split energy dispersion in high-mobility single-layer graphene/WSe heterostructures
Authors: Bid Aveek , Tiwari Priya , Jat Mohit Kumar , Udupa Adithi , Narang Deepa , Watanabe Kenji , Taniguchi Takashi , Sen Diptiman 
Published: June 2022

Abstract
In this letter, we report the experimental determination of the band structure of single-layer graphene (SLG) in the presence of strong proximity-induced spin-orbit coupling. We achieve this in high-mobility hBN-encapsulated SLG/WSe2 heterostructures through measurements of quantum oscillations. We observe clear spin-splitting of the graphene bands along with a substantial increase in the Fermi velocity. Using a theoretical model with realistic parameters to fit our experimental data, we uncover evidence of a bandgap opening and band inversion in the SLG. Further, we establish that the deviation of the low-energy band structure from pristine SLG is determined primarily by the valley-Zeeman SOC and Rashba SOC, with the Kane-Mele SOC being inconsequential. Despite robust theoretical predictions and observations of band-splitting, a quantitative measure of the spin-splitting of the valence and the conduction bands and the consequent low-energy dispersion relation in SLG was missing -- our combined experimental and theoretical study fills this lacuna.
Screening behaviors, demographics, and stage at diagnosis in the publicly funded Ontario Breast Cancer Screening Program.
Authors: Gold Nicholas , Christensen Rebecca A.G , Anderson Geoffrey M , Brooks Jennifer D. 
Published: June 2022

Abstract
Purpose. The Ontario Breast Screening Program (OBSP) offers free screening mammograms every two years, to women aged 50-74. Study objectives were to determine demographic characteristics associated with adherence to OBSP and if women screened in OBSP have a lower stage at diagnosis than non-screened eligible women. Methods. We used the Ontario Cancer Registry (OCR) to identify 51,617 women, aged 50-74, diagnosed with breast cancer between 2010-2017. These women were assigned as screened (N=33,821) or non-screened (N=17,796) in OBSP. We used logistic regression to investigate the demographic characteristics associated with non-screening behaviour. We used multinomial regression to examine the association between screening status and stage at diagnosis.Results. Among women with breast cancer, those living in rural areas (versus the largest urban areas) had a lower odds ratio (OR) of not being screened (OR: 0.76, 95%CI: 0.72-0.81). Women in low income (versus high income) communities were more likely not to be screened (OR: 1.35, 95%CI: 1.27-1.43). When stratified, the association between income and screening status only held in urban areas. Non-screened women were more likely to be diagnosed stage II (OR: 1.76, 95%CI: 1.68-1.85), III (OR: 2.73, 95%CI: 2.56-2.92), or IV (OR: 6.93, 95%CI: 6.24-7.69) disease compared to stage I and were less likely to be diagnosed with ductal carcinoma in-situ (DCIS) (OR: 0.90, 95%CI: 0.85-0.96). Conclusions. This study suggests that targeting OBSP recruitment efforts to lower income urban communities could increase screening rates. OBSP adherent women were more likely to be diagnosed at earlier stages, supporting the value of this initiative and those like it.
A Phase II Trial of the JAK-Inhibitor Ruxolitinib with Exemestane for Estrogen Receptor Positive, Aromatase Inhibitor Resistant, Advanced Breast Cancer
Authors: Makhlin Igor , McAndrew Nicholas , Wileyto E. , Clark Amy , Holmes Robin , Bottalico Lisa , Mesaros Clementina , Blair Ian , Jeschke Grace , Fox Kevin , Domchek Susan , Matro Jennifer , Bradbury Angela , Feldman Michael , Hexner Elizaabeth , Bromberg Jacqueline , DeMichele Angela 
Published: June 2022

Abstract
PURPOSE
Circulating IL-6, an activator of JAK/STAT signaling, is associated with poor outcomes and aromatase inhibitor (AI) resistance in hormone-receptor positive (HR+) breast cancer. We investigated the safety and efficacy of ruxolitinib, an oral selective inhibitor of JAK1/2, given with exemestane in patients with HR + metastatic breast cancer (MBC) after progression on a non-steroidal AI (NSAI) and whether inflammatory biomarkers predict response.
METHODS
Participants had HR + MBC that relapsed on or within two years of adjuvant NSAI or progressed on NSAI for MBC. The trial was a phase II Simon two-stage design; primary objectives were safety and efficacy. Ruxolitinib, at a starting dose of 25mg twice daily, and exemestane, 25mg daily, were given continuously in the first stage; Grade 3/4 toxicity in < 5/15 participants enabled stage 2. Primary tumor and serial blood samples were collected.
RESULTS
Twenty-five subjects were enrolled. The combination of ruxolitinib and exemestane was safe and tolerable, though anemia requiring transfusion was a frequent adverse event at the 25 mg dose, leading to a reduction in the starting dose of 15 mg twice daily in stage 2. The clinical benefit rate (CBR) in the overall study population was 24% (95% CI 9.4–45.1) with 6/25 patients demonstrating stable disease for ≥ 6 months. Median progression free survival was 2.8 months (95% CI 2.6–3.9). Exploratory biomarkers revealed a cohort with high levels of systemic inflammation: 60% harbored a high-risk IL-6 promoter genotype. Pharmacodynamic investigation demonstrated only a modest on-target inhibition of phosphorylated-STAT3 by ruxolitinib at the doses given.
CONCLUSION
Ruxolitinib combined with exemestane was feasible but lacked clinically meaningful efficacy, with only modest on-target inhibition in AI-resistant tumors when administered at a tolerable dose to a cohort of patients with high levels of systemic inflammation. These findings highlight the need for more potent and specific therapies targeting inflammation in endocrine-resistant breast cancer.
Geochemical characterization of late Jurassic – early Cretaceous age limestones from Gümüşhane (NE-Turkey): Identification of the source of organic matter and paleo-environment conditions
Authors: Eker Çiğdem Saydam , ARI Uğur Volkan 
Published: June 2022

Abstract
Samples from late Jurassic – early Cretaceous age Limestones in five different areas in the Gümüşhane region (NE-Turkey), were studied using TOC/Rock-Eval and some trace elements analysis, to evaluate them their organic material source, type, thermal maturity, and paleo-environment conditions. The studied carbonate rocks are characterized by 90 m thick in the Bağlarbaşı section, 420 m in the Gülaçar, 584 m in the Ünlüpınar, 375 m in the Mescitli, and 272 m in the Yuvacık. The carbonate rocks are generally represented by, from bottom to top, dolomite, oolitic, sparitic, sandy, micritic, clayey, and bituminous limestones. Average total organic carbon (TOC) values are 0.14, 0.16, 0.20, 0.12, and 0.20% in the Bağlarbaşı, Gülaçar, Ünlüpınar, Mescitli, and Yuvacık sections, respectively. Organic material in the limestones consists of Type II-III kerogen, indicating that a mixture of terrigenous higher plants – marine aquatic organisms was the main source. Average Tmax values and Tmax-based vitrinite reflectance values (Ro %) are calculated as 435 and 0.67, 444 and 0.83, 431 and 0.60, 442 and 0.79, and 437oC and 0.70 in the Bağlarbaşı, Gülaçar, Ünlüpınar, Mescitli, and Yuvacık sections, respectively indicating that the samples have generally reached thermal maturity. The limestones in the Gülaçar, Mescitli, and Yuvacık areas are probably well-drained rocks that were extracted and originated hydrocarbon efficiently from the limestone fractures. A non-marine – marine deposition environment for the carbonates is supported by organic sulfur values. V/Ni and Sr/Ba ratios indicate a stratified water column with high – low salinity and anoxic – oxic bottom water circumstances.
Isolation and characterization of an anti- proliferative polysaccharide from the North American fungus Echinodontium tinctorium
Authors: Zeb Mehreen , Li Wai Ming , Heiss Christian , Black Ian , Tackaberry Linda E. , Massicotte Hugues B. , Egger Keith N. , Reimer Kerry , Azadi Parastoo , Lee Chow H. 
Published: June 2022

Abstract
A novel polysaccharide EtGIPL1a was purified from fruiting bodies of Echinodontium tinctorium, a fungus unique to western North America. EtGIPL1a has an estimated weight average molecular weight of 275 kDa and is composed of glucose (54.3%), galactose (19.6%), mannose (11.1%), fucose (10.3%), glucuronic acid (4%), and rhamnose (0.6%). It has multiple glycosidic linkages, with 3-Glcp (28.9%), 6-Glcp (18.3%), 3,6-Glcp (13%), 4-GlcpA (9.2%), 6-Galp (3.9%), 2,6-Galp (2.6%), 3-Fucp (2.5%), 6-Manp (2.4%) being the most prominent, and unsubstituted glucose (15.3%), mannose (1.3%) and fucose (0.9%) as major terminal sugars. EtGIPL1a has a backbone containing mostly 3-substituted β-glucopyranose with 4-substituted glucopyranosyluronic acid. EtGIPL1a showed anti-proliferative activity against multiple cancer cell lines, with IC50 ranging from 50.6–1446 nM. Flow cytometry analyses confirmed that apoptosis induction is one mechanism for its anti-proliferative activity. EtGIPL1a should be further investigated for its potential anti-cancer activity in animal models, and for its possible utility in differentiation cancer therapy.
Ionically Complexed Nanoparticles for Heparin Oral Delivery
Authors: Subramaniam Bhagyashree , Leonick Nicole , Gade Verenya , Frey David , Zhang Fuming , Linhardt Robert J , Gross Richard 
Published: June 2022

Abstract

Ionically complexed nanoparticles were prepared from an anionic polysaccharide drug, heparin, entrapped by a positively charged chitosan polysaccharide. In this study, the encapsulation of heparin was studied to optimize properties needed for its oral drug delivery. Chitosan, used in a variety of biomedical applications, was selected as a cationic polymer for heparin encapsulation. These particles were prepared with a slightly positive charge and an appropriate size for oral drug delivery. The release profiles of these ionically complexed nanoparticles were improved by using FDA approved stabilizers, such as pluronic non-ionic surfactant and polyvinyl alcohol. These results obtained in vitro suggest that these stabilized, ionically complexed nanoparticles may be well-suited for the oral drug delivery of heparin into the gastrointestinal tract.
Cytotoxic effect of ApoL1r in bovine epithelial kidney cells as an alternative treatment for Trypanosoma spp. in cattle
Authors: Jaramillo-Delgado Ingrid Lorena , Agudelo-Florez Piedad , Ruiz-Buitrago Jhon Didier 
Published: June 2022

Abstract
ApoL 1 has been considered as a good alternative to Trypanosoma spp treatment but is also related to kidney cytotoxicity in some mammals. The cytotoxic effect of the recombinant ApoL1 (ApoL1r) protein on bovine renal epithelial cells was evaluated in vitro. This cytotoxic effect led to an up to 50% decrease in cell viability. These results were comparable to those obtained through positive damage control (MM8 at 200 and 250 ug/ml). It was determined that the ApoL1r protein could not be used in experimental animal models, specifically in cattle, due to the loss of cell viability that was generated.
Superficial capillary plexus vessel density/deep capillary plexus vessel density ratio in healthy eyes
Authors: Nam Ki-Yup , lee minwoo , Lee Kook-Hyung , Kim Jung-Yeul 
Published: June 2022

Abstract
Purpose: To identify factors differently affecting the superficial capillary plexus (SCP) and deep capillary plexus (DCP) in healthy eyes using their vessel density (VD) ratio.Methods: Healthy eyes were enrolled. The ratio between the VD of SCP and DCP (SVD/DVD ratio) was calculated. Pearson correlation analyses were performed to identify the relationships between this ratio and other factors.Results: The mean SVD and DVD were 36.0 ± 5.9 and 37.4 ± 4.8 %, respectively, and the mean SVD/DVD ratio was 0.96 ± 0.12. The SVD was significantly correlated with the best-corrected visual aucity (BCVA) (coefficient = -0.338, P < 0.001), age (coefficient = -0.389, P < 0.001), and OCTA quality (coefficient = 0.593, P < 0.001). The DVD was significantly correlated with the BCVA (coefficient = -0.194, P = 0.004), age (coefficient = -0.247, P < 0.001), and OCTA quality (coefficient = 0.507, P < 0.001). Among various factors, age (coefficient = -0.274, P < 0.001), the BCVA (coefficient = -2.80, P < 0.001), axial length (coefficient = 0.198, P = 0.003), and OCTA quality (coefficient = 0.271, P < 0.001) were significantly correlated with the SVD/DVD ratio.Conclusions: Age, BCVA, axial length, and OCTA image quality were significantly correlated with the SVD/DVD ratio. Age, the BCVA, and OCTA quality were more strongly correlated with the SCP, and the axial length was more strongly correlated with the DCP.
Clinical outcome analysis of sequential transplantation of frozen-thawed embryo transfer cycle
Authors: Zhou Wenjing , Cheng Zhaojun , Wang Chong , Feng Ying 
Published: June 2022

Abstract
Research Question: What were the advantages or disadvantages of sequential transplantation compared with the other two strategies in freeze-thaw embryo transfer? Design: A total of 767 patients undergoing frozen-thawed embryo transfer from July 1, 2020, to June 30, 2021, were enrolled in this study. All patients were divided into three groups based on the age of embryos: group A consisted of 60 cases of sequential transplantation, group B consisted of 576 cases of early embryo transfer, while group C was the blastocyst transplantation group consisting of 131 cases. The clinical data, embryo status, and pregnancy outcome in the three groups were compared and analyzed.Results: The number of subsequent transplants and the number of embryos transferred in the sequential group were significantly higher than those in the other two groups (p < 0.05). The blastocyst group (group C) had the highest implantation rate, which was significantly different from the early embryo group (group B, 43.50% vs. 30.00%), but there was no significant difference in the other two groups (39.13% vs. 30.00%, 39.13 vs. 43.50%). The sequential transfer group had the highest rate of multiple births and spontaneous abortion among the three groups, but there was no statistical difference.Conclusion: Sequential transplantation may achieve a higher clinical pregnancy rate than traditional single transplantation by increasing the number of transplants and embryos in a single cycle. Still, it increases embryo waste and may increase the rate of early abortion. The basic situation of the patient should be integrated to decide on the type of embryo transplant.
LINC01956 promotes metastasis and M2 polarization of tumor-associated macrophages in glioblastoma via the FUS/β-catenin signaling pathway
Authors: Zhang Gong , Jin Fa , Lu Fengfei , Zhao Lihong , deng xubin 
Published: June 2022

Abstract
Long noncoding RNAs (lncRNAs) can drive cancer progression. Here, we studied the role of a novel lncRNA, LINC01956, in glioblastoma (GBM). The level of LINC01956 was elevated in GBM cell lines and tissues. LINC01956 downregulation suppressed the migration and proliferation of GBM cells both in vitro and in vivo. Silencing of LINC01956 also significantly suppressed the growth of patient-derived organoids. M2 polarization of macrophages induced by exosomes derived from glioma cells overexpressing LINC01956 further accelerated GBM progression. Mechanistically, we found that FUS interacted with both LINC01956 and β-catenin. LINC01956 bound to FUS and reduced its ubiquitination. LINC01956 evoked nuclear translocation of phosphorylated (p)-β-catenin by recruiting FUS. Furthermore, under hypoxic conditions, LINC01956 was regulated by HIF-1α. Taken together, our data revealed for the first time that LINC01956 exerts pro-tumor effects via FUS-dependent activation of the WNT/β-catenin signaling pathway.
Role of same-day sequential approach – ERCP guided biliary clearance followed by Laparoscopic Cholecystectomy – in the management of Choledocholithiasis with concomitant Cholelithiasis: Prospective interventional single-centre study
Authors: Tantia Mridul , Suryawanshi Pravin , Gandhi Ashish 
Published: June 2022

Abstract
Background:
Early laparoscopic cholecystectomy (LC) after endoscopic retrograde cholangio-pancreaticography (ERCP) is beneficial for patients with gall stone disease (GSD) and common bile duct (CBD) stones. However there are no clear guidelines for the optimal timing of surgical intervention. This study aimed to assess the feasibility and clinical outcomes of same-day sequential approach – ERCP followed by LC for management of choledocholithiasis and concomitant cholelithiasis.
Materials and Methods:
Between December 2017 and November 2019, 24 patients diagnosed with choledocholithiasis and concomitant cholelithiasis underwent ERCP guided biliary clearance followed by LC sequentially on the same day. ERCP was done in the endoscopy suite, and followed by LC in the operation theatre. Both the procedures were performed by same endoscopist-cum-laparoscopic surgeon proficient in advanced endoscopy and laparoscopy. Success rate, ERCP findings, operative findings, logistic issues and complications were recorded and analysed.
Results:
Technical success for ERCP and LC, both were 100%. No major complications like bleeding, perforation, pancreatitis or mortality were encountered post-ERCP. Rate of conversion to open cholecystectomy was 0%. Post-operative self-resolving minor bile leak was encountered in 1 patient (4.1%) who was managed conservatively. The mean time for ERCP and LC was 33.33 minutes and 80.4 minutes, respectively. The mean time interval between the two procedures was 51 minutes. The mean post procedure hospital stay was 3.7 days.
Conclusion:
This study demonstrates safe, effective and feasible same-day sequential approach - ERCP guided biliary clearance followed by LC - in selected patients with choledocholithiasis with concomitant cholelithiasis
PCR based methodology for gender identification in date palm (Phoenix dactylifera L.) of Gujarat, India
Authors: Jani Mansi , Patel Fenil , Abbas Haidar , Joshi Chaitanya , Joshi Madhvi 
Published: June 2022

Abstract
Date palm (Phoenix dactylifera L.) is important dioecious plant in which male and female sex flowers are on different plant. The gender identification of date palm is only possible after 4–8 years when flowers developed. The date palm fruits are produced only on female plants, therefore identification of gender in date palm plants is essential for selection of female plants at seedling stage and increasing production. Currently, there is no consistent methodology available for the sex determination in date palm. There are several DNA marker-based methods available but none can provide truthful results for date palm sex identification. Here we focused on PCR based sex determination of date palm with Glycerol-3 phosphate acetyl transferase (GPAT3) male specific primer and LOX5.1 as positive control. GPAT3 plays important role in male fertility. According to results GPAT3 amplification only occur in male date palm samples, not in female. So that, if result of PCR amplification produced two bands than male and if one band than it is female. We further validated these primers to 315 date palm samples of Kutch region of Gujarat. Out of which, from 304 samples, we can successfully identify gender of date palm with p-value of 0.809 which indicate that the technique is efficient to differentiate sex of date palm.