bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can Intranasal Administration of Adipose-Derived Stem Cells Reach and Affect the Histological Structure of Distant Organs of Aged Wistar Rat?
Authors: Hamam Ghada Galal , Bahaa Nevine , Raafat Mona H. 
Published: November 2022

Introduction:
Stem cell therapy is a highly promising strategy in various degenerative diseases. Intranasal administration of stem cells could be considered as a non-invasive treatment option. However, there is great debate concerning the ability of stem cells to reach distant organs. It is also unclear in such a case if they can alleviate age-related structural changes in these organs.

Aim:
The aim of this study is to evaluate the ability of intranasal administration of adipose-derived stem cells (ADSCs) to reach distant organs of rats at different time intervals and to investigate their effects on age-related structural changes in these organs.

Materials and Methods:
Forty-nine female Wistar rats were used in this study, seven of which were adults (6-month-old) and 42 were aged (2-year-old). Rats were divided into three-groups: Group-I (adult control), Group-II (aged), and Group-III (aged ADSCs treated). Rats of Groups I and II were sacrificed after 15 days from the beginning of the experiment. Rats of Group III were treated with intranasal ADSCs and were sacrificed after 2-h, 1-day, 3-day, 5-day, and 15-day. Heart, liver, kidney, and spleen specimens were collected and processed for H and E, CD105 immunohistochemistry, and immunofluorescent techniques. Morphometric study and statistical analysis were performed.

Results:
ADSCs appeared in all organs examined after 2-h of intranasal administration. Their maximum presence was detected after 3-day of administration, after which their immunofluorescence gradually decreased and nearly disappeared from these organs by the 15th day. Improvement of some age-related deterioration in the structure of the kidney and liver occurred at day 5 after intranasal administration.

Conclusions:
ADSCs effectively reached the heart, liver, kidney, and spleen after intranasal administration. ADSCs ameliorated some age-related changes in these organs.
Relevance of Conventional Microscopy in the Diagnosis of Mucormycosis during COVID-19 Pandemic
Authors: Vidyarthi Ashima Jain , Das Arghya , Khan Salman , Panda Smriti , Singh Gagandeep , Thakar Alok , Bhatnagar Sushma , Xess Immaculata , Chaudhry Rama 
Published: November 2022

Abstract

Introduction:
Mucormycosis is a lethal disease which bewildered the health-care community of India during the ongoing second wave of the COVID-19 pandemic. The diagnosis is challenging considering the poor isolation in culture.

Aims:
The aim of the study was to emphasize the utility of potassium hydroxide (KOH) mount examination using conventional light microscopy for early diagnosis of mucormycosis in resource-limited settings.

Materials and Methods:
A retrospective analysis of results for all the samples including tissue biopsies, swabs, and pus received in the laboratory for KOH microscopy was done, and results were recorded. The clinical and demographic details of the patients were collected from the hospital information system.

Results:
A total of 75 samples from 50 patients were received in the laboratory. Out of these, 43 samples from 35 patients showed fungal hyphae (38 patients with only nonseptate hyaline hyphae, 2 with septate hyaline hyphae, and 3 samples with mixed infections). All patients except one were positive for severe acute respiratory syndrome coronavirus 2 infection. The most common age group was 45–59 years (40%), followed by 30–44 years (34.28%) with a male predominance. There was a significant difference in hemoglobin A1C (P = 0.005) and ferritin (P = 0.017) levels between laboratory-confirmed mucormycosis patients and clinically suspected mucormycosis patients without confirmation.

Conclusion:
Early diagnosis and initiation of targeted therapy is the cornerstone for treating mucormycosis patients. Hence, a rapid and reliable mode of diagnosis is the need of the hour. Conventional microscopy is such a tool that may be used, especially in resource-limited settings.
Contrast radiographic anatomy of the gastrointestinal tract of white-bellied pangolin
Authors: Ogunleye Adepeju T , Olatunji-Akioye Adenike O. , Emikpe Benjamin O. , Jarikre Theophilus A. , Omotosho Oladipo O. , Olajumoke A Morenikeji 
Published: November 2022

Context:
Pangolins are scaly ant-eating placental mammals threatened with extinction due to over-exploitation and poaching. Aggressive protection by conservationists is moderately successful due to scanty information regarding their physiology.

Aims:
Contrast radiography, a diagnostic technique for investigating gastrointestinal diseases may assist conservation efforts to improve the survival of these animals.

Subjects and Methods:
Eight rescued white-bellied pangolins of different ages, sexes, and weights were evaluated. Four live ones; with a mean weight of 1.52 ± 0.3 kg were radiographed and measurements taken by Digimizer. Four others had an opportunistic necropsy done and gross measurements of the gastrointestinal tract. Sedation with Ketamine caused uncurling, facilitated handling, and barium was administered orally. Serial dorso-ventral and lateral radiographs, physiological parameters, gastrointestinal dimensions, and contrast images were acquired.

Results:
The oral cavity was oval-shaped with no teeth; the long thin tongue runs beside the esophagus and contrast within the stomach 0 min postadmin lends credence to the length of the tongue just proximal to the stomach at the 8th thoracic rib. The plain radiograph revealed stones within the stomach at the 10th thoracic rib. The esophageal length, stomach length, and width radiographically, were 201.38 ± 1.70, 95.42 ± 1.9, and 53.02 ± 16.70 mm while the gross gastric length, diameter, and intestinal length were 7.1 ± 0.12, 13.3 ± 0.4, and 220.21 ± 4.03 cm, respectively. The mean contrast transit time was 1.34 ± 0.65 h-stomach, 0.48 ± 0.48 h-small intestines, and 10.00 ± 5.76 h-large intestines. Compared to mean transit times in dogs, it is longer but shorter when the transit times are compared to mean transit times in rats.

Conclusion:
Average transit time of the digestive tract is consistent with the reported average in dogs (3 ± 1.5 h). Implications for feeding and gut health in pangolins can assist in understanding critical care and boost conservation efforts.
An observational study of the demographic, clinical, and diffusion-weighted magnetic resonance imaging characteristics of patients with musculoskeletal infections
Authors: Yadav Rishabh , Narula Harneet , Mittal Amit , Kumar Akshay , Mittal Sahil 
Published: November 2022

Introduction:
Musculoskeletal infections have been emerging nowadays. Its early diagnosis is warranted as it may lead to disabling sequelae. Recently, the use of diffusion-weighted magnetic resonance imaging (DWMRI) provided additional pulse sequences enabling better diagnosis and needs to be explored for diagnosing musculoskeletal infections. Thus, we conducted this study with an aim to discuss demographic, clinical, and DWMRI findings of the spectrum of musculoskeletal infections, emphasizing the apparent diffusion coefficient (ADC) map for this domain of infections.

Methods:
A retrospective observational study was carried out in the department of radiodiagnosis of a tertiary care hospital. The study was performed on 50 patients who were suspected cases of musculoskeletal infections. All the patients underwent basic investigations, ultrasound, magnetic resonance imaging, and diffusion-weighted imaging with ADC mapping. The data were entered into MS EXCEL spreadsheet and analysis was done using Statistical Package for Social Sciences (SPSS) version 21.0.

Results:
Maximum patients were in the age group of 11–20 years (40%) with 58% males and 42% females. Lower limb infections were common, especially the involvement of the hip joint. Pain and swelling were the most common symptoms as seen in 96% and 88% of the patients respectively. DWMRI was able to diagnose and lay down significantly different ADC values for different musculoskeletal infections. The mean ADC values were higher for acute infections and lower for chronic infections.

Conclusions:
DWMRI holds an important role in the investigation profile for musculoskeletal infections and must be used wherever deemed necessary to avoid unnecessary referrals and treatments.
Basic loci of Coxeter type with arbitrary parahoric level
Authors: Görtz Ulrich , He Xuhua , Nie Sian 
Published: November 2022

AbstractMotivated by the desire to understand the geometry of the basic loci in the reduction of Shimura varieties, we study their “group-theoretic models”—generalized affine Deligne–Lusztig varieties—in cases where they have a particularly nice description. Continuing the work of Görtz and He (2015, Cambridge Journal of Mathematics 3, 323–353) and Görtz, He, and Nie (2019, Peking Mathematical Journal 2, 99–154), we single out the class of cases of Coxeter type, give a characterization in terms of the dimension, and obtain a complete classification. We also discuss known, new, and open cases from the point of view of Shimura varieties/Rapoport–Zink spaces.
Case Report: Autochthonous Disseminated Cutaneous, Mucocutaneous, and Visceral Leishmaniasis Caused by Leishmania martiniquensis in a Patient with HIV/AIDS from Northern Thailand and Literature Review
Authors: Srivarasat Saranya , Brownell Narisa , Siriyasatien Padet , Noppakun Nopadon , Asawanonda Pravit , Rattanakorn Krittaya , Preativatanyou Kanok , Kumtornrut Chanat 
Published: November 2022

ABSTRACT.
Autochthonous leishmaniasis cases have been increasing continuously in Thailand over the years. We report multiple presentations of leishmaniasis in a 47-year-old patient with HIV/AIDS from Chiang Rai Province, northern Thailand. Physical examination showed multiple ulcerated papules, nodules, and plaques in a sporotrichoid distribution. Firm mucosal nodules on the hard palate and nasal opening, hepatosplenomegaly, and bilateral inguinal lymphadenopathy were found. Histopathological examination of the biopsies revealed an inflammatory infiltrate containing intramacrophage amastigotes compatible with Leishmania infection. In addition, Leishmania promastigotes were isolated successfully from the palatal biopsy and assigned the code MHOM/TH/2022/CULE6. Using internal transcribed spacer 1 polymerase chain reaction and sequence analysis, the causative parasite was identified as Leishmania martiniquensis. A definitive diagnosis of multiform leishmaniasis with disseminated cutaneous, mucocutaneous, and visceral involvement was established. The patient was administered intravenous amphotericin B 1 mg/kg/d for 2 weeks, followed by oral itraconazole 400 mg daily. At the 2-month follow-up, the cutaneous and mucosal lesions had improved significantly. To our knowledge, this is the first report of mucocutaneous involvement caused by L. martiniquensis in an immunocompromised patient with HIV/AIDS. In addition, we provide a literature review of leishmaniasis cases, reported formally in Thailand, resulting from this autochthonous parasite.
Arbovirus Antibody Seroprevalence in the Human Population from Cauca, Colombia
Authors: Gil-Mora Juliana , Acevedo-Gutiérrez L. Yoana , Betancourt-Ruiz Paola L. , Martínez-Diaz Heidy C. , Fernández Diana , Bopp Nathen E. , Olaya-Másmela Luz A. , Bolaños Eliana , Benavides Efraín , Villasante-Tezanos Alejandro , Hidalgo Marylin , Aguilar Patricia V. 
Published: November 2022

ABSTRACT.
Several arboviruses have emerged or reemerged into the New World during the past several decades, causing outbreaks of significant proportion. In particular, the outbreaks of Dengue virus (DENV), Zika virus, and Chikungunya virus (CHIKV) have been explosive and unpredictable, and have led to significant adverse health effects. These viruses are considered the leading cause of acute undifferentiated febrile illnesses in Colombia. However, Venezuelan equine encephalitis virus (VEEV) is endemic in Colombia, and arboviruses such as the Mayaro virus (MAYV) and the Oropouche virus (OROV) cause febrile illnesses in neighboring countries. Yet, evidence of human exposure to MAYV and OROV in Colombia is scarce. In this study, we conducted a serosurvey study in healthy individuals from the Cauca Department in Colombia. We assessed the seroprevalence of antibodies against multiple arboviruses, including DENV serotype 2, CHIKV, VEEV, MAYV, and OROV. Based on serological analyses, we found that the overall seroprevalence for DENV serotype 2 was 30%, 1% for MAYV, 2.6% for CHIKV, 4.4% for VEEV, and 2% for OROV. This study provides evidence about the circulation of MAYV and OROV in Colombia, and suggests that they—along with VEEV and CHIKV—might be responsible for cases of acute undifferentiated febrile illnesses that remain undiagnosed in the region. The study results also highlight the need to strengthen surveillance programs to identify outbreaks caused by these and other vector-borne pathogens.
სხვადასხვა ეკონომიკური სისტემების ბიზნეს გარემოს მახასიათებლები
Authors: Sapharidze Guram 
Published: November 2022

გურამ საფარიძე
ბიზნესის ადმინისტრირების დოქტორი, ბათუმის შოთა რუსთაველის სახელმწიფო უნივერსიტეტი, ბათუმი, საქართველო
Email: sapharidzeguram@gmail.com
https://orcid.org/0000-0001-6776-3482

მოკლე აღწერა
აბსტრაქტი. სტატიაში განხილულია ეკონომიკური სისტე­მე­ბის ინტეგრირების პროცესი, ბიბლიოგრაფიულ კვლე­ვებ­ზე და სტა­ტისტიკურ მასალებზე დაყრდნობით გაკეთე­ბუ­ლია შესაბამისი დასკვნები და რეკომენდაციები. აღ­მოჩნ­და, რომ ეკონომიკური სისტემები განსხვავდებიან სა­ერ­თაშორისო გახნილობის დონის, ინტეგრირებისკენ სწრაფ­­ვის და ცვლილებების მიმართ ეკონომი­კურ აგენტთა დამოკიდებულების მიხედვით. ბიზნეს გარემო ყო­ველ კონკრეტულ ეკონომიკურ სისტემაში ყალიბდება მაკრო, მიკრო, სოციალური ეკო და გლობალური ფაქტორების ზე­გავ­ლე­ნით. გარდა ამისა, ბიზნეს გარემო ყოველი კონკრე­ტუ­ლი ბიზ­ნეს ორგანიზაციისთვის განსხვავებულია იმის მიხედვით, თუ რა მასშტაბის ეკონომიკურ სისტემაში მოქ­მე­დებს იგი. ეკონომიკური ინტეგრაცია განიხილება, რო­გორც პროცესი, რომლის ფარგლებ­შიც რამდენიმე ეკონო­მი­კური სისტემა ცდილობს დამსგავსებას. მიიღება ეკონომი­კური სისტემა, და შესაბამისად, ბიზნეს გარემო, რომლის საკვანძო იდეოლოგია წარმოადგენს დამსგავსების მთა­ვარ ორიენტირს, ხოლო ეკონომიკურ აგენტთა ურთიერთქმე­დება ამ ორიენტირთან მიახლოების და მისი პრაქტიკული განხოციე­ლე­ბის შესაძლებლობას იძლევა. ბიზნეს გარემოს ცვლილება იწვევს ახალი გადაწყვეტილებების მიღებას ბიზ­ნეს სუბიექტების მიერ. ცვლილებები ასევე გავლენას ახდენენ გადაწყვეტილებების მიღების პროცესზე.
ქალი მეზღვაური
Authors: Tchkonia Natalia 
Published: November 2022

ნატალია ჭყონია
ასოცირებული პროფესორი, ბათუმის ნავიგაციის სასწავლო უნივერსიტეტი, ბათუმი, საქართველო
Email: n.tchkonia@bntu.edu.ge
https://orcid.org/0000-0002-8117-4146

მოკლე აღწერა
აბსტრაქტი. დღევანდელი ქალი ნაბიჯ-ნაბიჯ არღვევს ბარიერებს. იშვიათი მოვლენა არაა, რომ ისტორიულად ქალები გამოირჩევიან მამაკაცებით დომინირებულ სფეროებში, როგორიცაა პოლიტიკა, ბიზნესი, მძლეოსნობა და კიდევ ბევრი რამ. ქალებს ბევრი ძლიე­რი ასპექტები აქვთ, რაც უნდა აღინიშნოს.
საზღვაო სფერო და საზღვაო პროფესიები სპეციფიკური და რა­დი­კა­ლურია. კვალიფიცირებული თანამშრომლები ზღვაზე თუ ხმე­ლეთზე აუცილებელია, რათა მოხდეს ქვეყნის ინდუსტრიული განვითარება. რეალურ დროში სახელმწიფო პოლიტიკა მიმართუ­ლია საზღვაო ბიზნესის მხარდაჭერასა და განვითარებაზე. აღ­სა­ნიშნავია, რომ მეზღვაურთა განათლებისა და მომზადების პრო­ცეს­ში ძალიან მნიშვნელოვანია ევროკავშირის მხარდაჭერა, რად­გან „ევროპული სტანდარტების დაცვა ქართველი მეზღვაურე­ბისთ­ვის ღირსეული დასაქმების გარანტიაა“. მეზღვაურები იმ იშვიათი პროფესიების წარმომადგენლები არიან, რომლებიც ექს­პორტს ახორციელებენ. ეს არის მომსახურება საქართველოდან, რაც რეგიონის ეკონომიკური სტაბილურობის ერთ - ერთი მნიშვ­ნე­ლოვანი კომპონენტია.
ბოლოს და ბოლოს, რა არის სათქმელი? რომ დღევანდელი ქა­ლე­ბი უფრო ძლიერები არიან, ვიდრე ოდესმე. საზოგადოებას სჭირ­დება და მოითხოვს მას. გენდერული თანასწორობა თანდათან იკიდებს ფეხს თანამედროვე სამყაროში, იქ სადაც ოდესღაც ქა­ლებს არ ჰქონდათ პოლიტიკური უფლებები და არ ჰქონდათ ხმის მიცემის შესაძლებლობა. ჩვენ გვჯერა, რომ შეხვედრები, რომ­ლებშიც მონაწილეობას მიიღებს მთავრობა, ბიზნესი და საზღვაო გაერთიანებები, მოეწყობა დასქმების საერთაშორისო ორგანიზა­ციების მიერ, რათა განიხილონ თუ როგორ გაზარდონ „ქალის“ დასაქმების შანსი ზღვაზე. უზრუნველყოფილი უნდა იყოს, რომ არც ერთი ქალი არ საჭიროებდეს თავის მართლებას. დაუფასდეს საქმე, რომელსაც ის ახორციელებს. იმედი მაქვს, რომ მსოფლიოს ქალები დაიბრუნებენ თავიანთ ხმას, გათავისუფლდებიან შეუ­რაცხ­ყოფისაგან და თავს დაცულად იგრძნობენ. ეს იქნება ერთი ნაბიჯი თანასწორობისკენ მიმავალ გზაზე.
ANALISIS SISTEM JARINGAN TEGANGAN MENENGAH 20 kV DI KAWASAN INDUSTRI KELAPA SAWIT PT. BUMITAMA GUNAJAYA AGRO
Authors: Darmawan Heri , Kurnianto Rudi , Gianto Rudi , Yusuf Ismail , Purwoharjono Purwoharjono 
Published: November 2022

Penelitian ini menganalisis perbaikan jaringan distribusi listrik PT. BGA, dikarenakan terjadi jatuh tegangan pada jaringan listrik existing sampai -20 % dan rencana peningkatan beban listik dari 118,6 kW menjadi 334,35 kW dalam bentuk model dan simulasi. Metode perbaikan yaitu membuat konspigurasi sistem jaringan distribusi listrik baru dan menganalisis aliran daya dengan ETAP . Hasil perbaikan dengan mengupgrading sistem tegangan distribusi menjadi 20 kV, pendistribusian beban listrik di buat menjadi empat kluster yaitu, cluster A, B, C dan D, upgrading transformator step up menjadi 500 kVA, transformator step down cluster A 200 kVA, cluster B dan C 125 kVA, cluster D 160 kVA, jaringan kabel distribusi primer menggunakan jenis AAAC (3x70 mm)2, jaringan distribusi sekunder masing-masing cluster menggunakan jenis NFA2X-T (3x70+1x50 mm)2 dan Saluran sambungan rumah menggunakan kabel jenis NFA2X (4x10 mm2 , 4x16 mm2 dan 4x25 mm)2. Hasil analisis aliran daya dengan ETAP, setelah dilakukan perbaikan, dimana jatuh tegangan yang terjadi pada keseluruhan bus beban listrik berkisar antara 0,3 sampai 4,7 % atau 0,379 kV sampai 0,362 kV, dimana nilai tersebut masih dalam standar tegangan yang di ijinkan yaitu untuk jaringan tegangan rendah (JTR) variasinya adalah maksimal + 5 % dan minimal -10 % terhadap tegangan nominal (SPLN1 : 1995).
ANALYSIS OF STUDENT ENGLISH COMMUNICATION USING SEMANTIC MAPPING STRATEGY
Authors: Harahap Sri Wida , Amini Sharfina Yusna , Lumbantobing Kesya Nirma 
Published: November 2022

Kemampuan berbahasa inggris berpengaruh besar dalam mendorong karier juga memperluas jaringan bisnis dan memungkinkan setiap orang untuk mengejar peluang karier sesuai dengan perubahan yang terjadi dalam perekonomian. Dalam beberapa dekade terakhir, Asia telah menjadi motor penggerak pertumbuhan ekonomi global, dipelopori oleh para pemimpin yang membangun hubungan internasional dan mendirikan perusahaan-perusahaan multinasional. Persaingan perekonomian di sektor swasta mendorong banyak perusahaan secara aktif mengutamakan kecakapan bahasa Inggris dan berinvestasi dalam mengembangkan kemampuan berbahasa Inggris. Kondisi ini mengharuskan penggunaan strategi yang tepat dalam pembelajaran bahasa Inggris. Penelitian ini bertujuan untuk menganalisa tingkat kemampuan komunikasi bahasa inggris mahasiswa menggunakan strategi Semantic Mapping. Hasil penelitian ini menunjukkan bahwa kemampuan komunikasi bahasa Inggris prodi Teknologi Elektromedik berada pada kategori rendah. Hal ini dapat dilihat dari skor perolehan penguasaan kosa kata. Disamping itu, mahasiswa masih sering membuat kesalahan tata Bahasa yang dapat mempengaruhi makna. Sehingga sering kali makna kalimat yang disampaikan menjadi berubah. Masih banyak mahasiswa yang pengucapan (pronounciation) nya dipengaruhi oleh aksen Bahasa daerahnya masing-masing.
ANALISIS AKSESIBILITAS MENUJU SEKOLAH DI KOTA DENPASAR
Authors: Wedagama Dewa Ayu Trisna Adhiswari , Suthanaya P Alit , Kwintaryana P 
Published: November 2022

Pembagian dan pertumbuhan kegiatan pendidikan di Kota Denpasar tidak dapat dikatakan merata, baik dari tingkat dasar hingga tingkat atas. Di penelitian ini dilakukan analisis mengenai aksesibilitas menuju sekolah di Kota Denpasar dimana faktor hambatannya adalah jarak. Aksesibilitas adalah ukuran keringanan atau keamanan untuk mencapai suatu tempat melalui sistem jaringan transportasi. Jika suatu tempat memiliki aksesibilitas yang tinggi, maka sistem transportasi di daerah tersebut dikatakan baik, begitupun sebaliknya. Penelitian ini bertujuan untuk memahami klasfikasi aksesibilitas, perkembangan aksesibilitas serta keseimbangan aksesibilitas menuju lokasi sekolah antar zona di Kota Denpasar selama tahun pengamatan (2012-2016). Dalam melakukan analisis ini dibutuhkan data sekunder, antara lain peta administrasi Kota Denpasar, peta jaringan jalan di Kota Denpasar, data jumlah sekolah yang ada di Kota Denpasar dari tingkat Sekolah Dasar (SD), Sekolah Menengah Pertama (SMP) dan Sekolah Menengah Atas/Sekolah Menengah Kejuruan (SMA/SMK) baik berstatus negeri maupun swasta. Kalkulasi aksesibilitas dilakukan dengan mengaplikasikan metode statistik deskriptif dan Indeks Hansen. Analisis yang dilakukan mencakup analisis aksesibilitas serta analisis perkembangan aksesibilitas. Apabila nilai aksesibilitas serta perkembangannya diperoleh, kemudian dilanjutkan membuat diagram Z-Score. Diagram Z-Score tersebut akan menunjukkan keseimbangan tingkat aksesibilitas antar zona. Dari pengkajian yang telah dilakukan, untuk tingkat aksesibilitas tinggi di Kota Denpasar dominan di Kecamatan Denpasar Timur dengan nilai aksesibilitas 83,235. Untuk tingkat aksesibilitas yang sangat rendah dominan di Kecamatan Denpasar Selatan dengan nilai aksesibilitas 42,614. Perkembangan aksesibilitas tinggi di Kota Denpasar dominan di Kecamatan Denpasar Selatan dengan nilai aksesibilitas sebesar 8,127. Perkembangan aksesibilitas yang sangat rendah dominan di Kecamatan Denpasar Utara dengan nilai aksesibilitas sebesar 3,311. Keseimbangan tingkat aksesibilitas sekolah di Kota Denpasar dapat diperhatikan dari hasil Z-Score. Hasil Z-Score menunjukkan bahwa terdapat zona-zona yang memiliki nilai aksesibilitas yang rendah dengan kecenderungan perkembangan menurun (kuadran III) dominan di Kecamatan Denpasar Utara.