bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manahau: Toward an Indigenous Māori theory of value
Authors: Mika Jason Paul , Dell Kiri , Newth Jamie , Houkamau Carla 
Published: February 2022

AbstractThe theoretical challenge posed by this paper is to find a conceptualisation of value for entrepreneurship theory grounded in Indigenous knowledge from a Māori perspective capable of guiding entrepreneurs operating for sustainability and wellbeing. We review Western and Māori theories of value, values, and valuation. We argue that Indigenous concepts of value centre on collective wellbeing as opposed to self-interest, and have spiritual and material elements. The paper proposes a tentative Māori theory of value we call manahau, which combines mana (power, authority, and dignity) and hau (vitality of people, places, and objects). We define manahau as an axiological agent Māori entrepreneurs employ to synergistically negotiate cultural and commercial imperatives to achieve multidimensional wellbeing, human potential, and relational balance. We discuss research which illustrates manifestations of manahau in the Māori cultural ethics of utu (reciprocity) in Māori entrepreneurship and tauutuutu (reciprocity and balance) in Māori agribusiness. We argue that an Indigenous Māori theory of value has implications for entrepreneurship theory and practice.
Light controlled frequency reconfigurable antenna for wireless applications
Authors: Reji V. , Manimegalai C. T. 
Published: February 2022

AbstractIn this paper, a light-controlled frequency reconfigurable antenna is presented for 5 G, WLAN, and radio altimeter applications. The given (44 × 28) mm2 antenna consists of a radiating V-shaped structure and three stub arrangements. The main λ/2 length stub is used to feed the antenna and the two λ/4, λ/8 length open-circuited stubs are located perpendicular to the main feeding stub for tuning the frequency of the antenna. The length of the stubs can be adjusted by placing (4 × 1.2) mm photodiode switches on the perpendicular stubs. Four experiments are carried out to analyze the performance of the antenna. When light and DC bias voltage is not applied (Experiment-1) to the photodiodes the proposed antenna radiates from 4.1 to 4.63 GHz with 12% bandwidth. When light is applied to the photodiode without DC bias voltage and DC bias voltage is applied without light (Experiment-2,3) the antenna reconfigures its frequency band from 3.43 to 3.6GHz and 4.8 to 5.4 GHz with 4.85% and 12% bandwidth respectively. The antenna shifts the radiation from 4.8 to 5.5 GHz with 14% bandwidth when the light and DC bias voltage is applied to the antenna(Experiment-4). The measured gain of the proposed antenna is greater than 3.8dBi in all the experiments.
Radial Anisotropy and Sediment Thickness of West and Central Antarctica Estimated From Rayleigh and Love Wave Velocities
Authors: Zhou Zhengyang , Wiens Douglas A. , Shen Weisen , Aster Richard C. , Nyblade Andrew , Wilson Terry J. 
Published: February 2022

AbstractMany recent Antarctic seismic structure studies use Rayleigh wave data and thus determine only the SV structure. Love waves provide greater resolution for shallow structure, and coupled with Rayleigh waves, can constrain radial anisotropy by comparing vertically (VSV) and horizontally (VSH) polarized shear velocities. In this study, we jointly analyze Rayleigh and Love wave phase and group velocities from ambient noise to develop a new radially anisotropic velocity model for West and Central Antarctica with an improved shallow crustal resolution using all broadband data collected in Antarctica over the past 20 years. Group and phase velocity maps for Rayleigh and Love waves are estimated and inverted for shear wave velocity structure using a Monte Carlo method. We determine a new sediment distribution map that reveals a thick sedimentary basin (∼4 km) beneath the Southeastern Ross Embayment. Sediment thicknesses at interior basins such as the Polar Subglacial Basin and Bentley Subglacial Trench are modest (<1.5 km), suggesting that these basins are sediment‐starved. The shallow crust as well as the mid‐to‐lower crust in several places shows strong positive anisotropy (VSH > VSV), likely due to lattice preferred orientation of mica‐bearing rocks. However, large regions of the mid‐to‐lower crust show negative anisotropy, likely due to lattice preferred orientation of plagioclase. The uppermost mantle is characterized by strong positive radial anisotropy (4%–8%) in West Antarctica, with the largest anisotropy beneath the Transantarctic and Whitmore Mountains, likely resulting from horizontal olivine preferred orientation due to tectonic activity.
Propofol toxicity in the developing mouse heart mitochondria
Authors: Barajas Matthew B. , Brunner Sarah D. , Wang Aili , Griffiths Keren K. , Levy Richard J. 
Published: February 2022

Abstract
Background
Propofol infusion syndrome (PRIS) is a potentially lethal consequence of long-term propofol administration. Children are vulnerable and cardiac involvement is often prominent and associated with mortality. We aimed to determine the mechanism of propofol toxicity in newborn mice, hypothesizing that propofol would induce discrete defects within immature cardiac mitochondria.

Methods
Newborn murine cardiac mitochondria were exposed to propofol or intralipid in vitro. Non-exposed mitochondria served as controls. Mitochondrial respiration and membrane potential (ΔΨ) were measured and respiratory chain complex kinetics were determined.

Results
Propofol and intralipid exerted biological activity in isolated mitochondria. Although intralipid effects were a potential confounder, we found that propofol induced a dose-dependent increase in proton leak and caused a defect in substrate oxidation at coenzyme Q (CoQ). These impairments prevented propofol-exposed cardiomyocyte mitochondria from generating an adequate ΔΨ. The addition of the quinone analog, CoQ0, blocked propofol-induced leak and increased Complex II+III activity.

Conclusions
Propofol uncoupled immature cardiomyocyte mitochondria by inducing excessive CoQ-sensitive leak and interfered with electron transport at CoQ. The findings provide new insight into the mechanisms of propofol toxicity in the developing heart and may help explain why children are vulnerable to developing PRIS.

Impact

Propofol uncouples immature cardiomyocyte mitochondria by inducing excessive coenzyme Q (CoQ)-sensitive proton leak.

Propofol also interferes with electron transport at the level of CoQ.

These defects provide new insight into propofol toxicity in the developing heart.
Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer
Authors: Patel Meera , Pennel Kathryn A. F. , Quinn Jean A. , Hood Hannah , Chang David K. , Biankin Andrew V. , Rebus Selma , Roseweir Antonia K. , Park James H. , Horgan Paul G. , McMillan Donald C. , Edwards Joanne 
Published: February 2022

Abstract
Background
To understand the relationship between key non-canonical NF-κB kinase IKK-alpha(α), tumour mutational profile and survival in primary colorectal cancer.

Methods
Immunohistochemical expression of IKKα was assessed in a cohort of 1030 patients who had undergone surgery for colorectal cancer using immunohistochemistry. Mutational tumour profile was examined using a customised gene panel. Immunofluorescence was used to identify the cellular location of punctate IKKα expression.

Results
Two patterns of IKKα expression were observed; firstly, in the tumour cell cytoplasm and secondly as discrete ‘punctate’ areas in a juxtanuclear position. Although cytoplasmic expression of IKKα was not associated with survival, high ‘punctate’ IKKα expression was associated with significantly reduced cancer-specific survival on multivariate analysis. High punctate expression of IKKα was associated with mutations in KRAS and PDGFRA. Dual immunofluorescence suggested punctate IKKα expression was co-located with the Golgi apparatus.

Conclusions
These results suggest the spatial expression of IKKα is a potential biomarker in colorectal cancer. This is associated with a differential mutational profile highlighting possible distinct signalling roles for IKKα in the context of colorectal cancer as well as potential implications for future treatment strategies using IKKα inhibitors.
Disruption of the grid cell network in a mouse model of early Alzheimer’s disease
Authors: Ying Johnson , Keinath Alexandra T. , Lavoie Raphael , Vigneault Erika , El Mestikawy Salah , Brandon Mark P. 
Published: February 2022

AbstractEarly-onset familial Alzheimer’s disease (AD) is marked by an aggressive buildup of amyloid beta (Aβ) proteins, yet the neural circuit operations impacted during the initial stages of Aβ pathogenesis remain elusive. Here, we report a coding impairment of the medial entorhinal cortex (MEC) grid cell network in the J20 transgenic mouse model of familial AD that over-expresses Aβ throughout the hippocampus and entorhinal cortex. Grid cells showed reduced spatial periodicity, spatial stability, and synchrony with interneurons and head-direction cells. In contrast, the spatial coding of non-grid cells within the MEC, and place cells within the hippocampus, remained intact. Grid cell deficits emerged at the earliest incidence of Aβ fibril deposition and coincided with impaired spatial memory performance in a path integration task. These results demonstrate that widespread Aβ-mediated damage to the entorhinal-hippocampal circuit results in an early impairment of the entorhinal grid cell network.
Depressive symptoms reduce when dorsolateral prefrontal cortex-precuneus connectivity normalizes after functional connectivity neurofeedback
Authors: Taylor Jessica Elizabeth , Yamada Takashi , Kawashima Takahiko , Kobayashi Yuko , Yoshihara Yujiro , Miyata Jun , Murai Toshiya , Kawato Mitsuo , Motegi Tomokazu 
Published: February 2022

AbstractDepressive disorders contribute heavily to global disease burden; This is possibly because patients are often treated homogeneously, despite having heterogeneous symptoms with differing underlying neural mechanisms. A novel treatment that can directly influence the neural circuit relevant to an individual patient’s subset of symptoms might more precisely and thus effectively aid in the alleviation of their specific symptoms. We tested this hypothesis in a proof-of-concept study using fMRI functional connectivity neurofeedback. We targeted connectivity between the left dorsolateral prefrontal cortex/middle frontal gyrus and the left precuneus/posterior cingulate cortex, because this connection has been well-established as relating to a specific subset of depressive symptoms. Specifically, this connectivity has been shown in a data-driven manner to be less anticorrelated in patients with melancholic depression than in healthy controls. Furthermore, a posterior cingulate dominant state—which results in a loss of this anticorrelation—is expected to specifically relate to an increase in rumination symptoms such as brooding. In line with predictions, we found that, with neurofeedback training, the more a participant normalized this connectivity (restored the anticorrelation), the more related (depressive and brooding symptoms), but not unrelated (trait anxiety), symptoms were reduced. Because these results look promising, this paradigm next needs to be examined with a greater sample size and with better controls. Nonetheless, here we provide preliminary evidence for a correlation between the normalization of a neural network and a reduction in related symptoms. Showing their reproducibility, these results were found in two experiments that took place several years apart by different experimenters. Indicative of its potential clinical utility, effects of this treatment remained one-two months later.Clinical trial registration: Both experiments reported here were registered clinical trials (UMIN000015249, jRCTs052180169).
Initial evidence of abnormal brain plasticity in anorexia nervosa: an ultra-high field study
Authors: Pappaianni Edoardo , Borsarini Bianca , Doucet Gaelle E. , Hochman Ayelet , Frangou Sophia , Micali Nadia 
Published: February 2022

AbstractAnorexia Nervosa has been associated with white matter abnormalities implicating subcortical abnormal myelination. Extending these findings to intracortical myelin has been challenging but ultra-high field neuroimaging offers new methodological opportunities. To test the integrity of intracortical myelin in AN we used 7 T neuroimaging to acquire T1-weighted images optimized for intracortical myelin from seven females with AN (age range: 18–33) and 11 healthy females (age range: 23–32). Intracortical T1 values (inverse index of myelin concentration) were extracted from 148 cortical regions at ten depth-levels across the cortical ribbon. Across all cortical regions, these levels were averaged to generate estimates of total intracortical myelin concentration and were clustered using principal component analyses into two clusters; the outer cluster comprised T1 values across depth-levels ranging from the CSF boundary to the middle of the cortical regions and the inner cluster comprised T1 values across depth-levels ranging from the middle of the cortical regions to the gray/white matter boundary. Individuals with AN exhibited higher T1 values (i.e., decreased intracortical myelin concentration) in all three metrics. It remains to be established if these abnormalities result from undernutrition or specific lipid nutritional imbalances, or are trait markers; and whether they may contribute to neurobiological deficits seen in AN.
Deep breathing couples CSF and venous flow dynamics
Authors: Kollmeier Jost M. , Gürbüz-Reiss Lukas , Sahoo Prativa , Badura Simon , Ellebracht Ben , Keck Mathilda , Gärtner Jutta , Ludwig Hans-Christoph , Frahm Jens , Dreha-Kulaczewski Steffi 
Published: February 2022

AbstractVenous system pathologies have increasingly been linked to clinically relevant disorders of CSF circulation whereas the exact coupling mechanisms still remain unknown. In this work, flow dynamics of both systems were studied using real-time phase-contrast flow MRI in 16 healthy subjects during normal and forced breathing. Flow evaluations in the aqueduct, at cervical level C3 and lumbar level L3 for both the CSF and venous fluid systems reveal temporal modulations by forced respiration. During normal breathing cardiac-related flow modulations prevailed, while forced breathing shifted the dominant frequency of both CSF and venous flow spectra towards the respiratory component and prompted a correlation between CSF and venous flow in the large vessels. The average of flow magnitude of CSF was increased during forced breathing at all spinal and intracranial positions. Venous flow in the large vessels of the upper body decreased and in the lower body increased during forced breathing. Deep respiration couples interdependent venous and brain fluid flow—most likely mediated by intrathoracic and intraabdominal pressure changes. Further insights into the driving forces of CSF and venous circulation and their correlation will facilitate our understanding how the venous system links to intracranial pressure regulation and of related forms of hydrocephalus.
Engineering topological phases in triple HgTe/CdTe quantum wells
Authors: Ferreira G. J. , Candido D. R. , Hernandez F. G. G. , Gusev G. M. , Olshanetsky E. B. , Mikhailov N. N. , Dvoretsky S. A. 
Published: February 2022

AbstractQuantum wells formed by layers of HgTe between Hg$$_{1-x}$$

1
-
x

Cd$$_x$$

x

Te barriers lead to two-dimensional (2D) topological insulators, as predicted by the BHZ model. Here, we theoretically and experimentally investigate the characteristics of triple HgTe quantum wells. We describe such heterostructure with a three dimensional $$8\times 8$$

8
×
8

Kane model, and use its eigenstates to derive an effective 2D Hamiltonian for the system. From these we obtain a phase diagram as a function of the well and barrier widths and we identify the different topological phases composed by zero, one, two, and three sets of edge states hybridized along the quantum wells. The phase transitions are characterized by a change of the spin Chern numbers and their corresponding band inversions. Complementary, transport measurements are experimentally investigated on a sample close to the transition line between the phases with one and two sets of edges states. Accordingly, for this sample we predict a gapless spectrum with low energy bulk conduction subbands given by one parabolic and one Dirac subband, and with edge states immersed in the bulk valence subbands. Consequently, we show that under these conditions, local and non-local transport measurements are inconclusive to characterize a sole edge state conductivity due to bulk conductivity. On the other hand, Shubnikov-de Haas (SdH) oscillations show an excellent agreement with our theory. Particularly, we show that the measured SdH oscillation frequencies agrees with our model and show clear signatures of the coexistence of a parabolic and Dirac subbands.
Intra-amniotic administration of l-glutamine promotes intestinal maturation and enteroendocrine stimulation in chick embryos
Authors: Reicher Naama , Melkman-Zehavi Tal , Dayan Jonathan , Uni Zehava 
Published: February 2022

AbstractInitial nutritional stimulation is a key driving force for small intestinal maturation. In chick embryos, administration of l-glutamine (Gln) into the amniotic fluid stimulates early development of the small intestinal epithelium by promoting enterocyte differentiation. In this study, we evaluated the effects of intra-amniotic administration of Gln on enterocyte morphology and function, and elucidated a potential enteroendocrine pathway through which Gln stimulates small intestinal maturation. Our results show that Gln stimulation at embryonic day 17 significantly increased enterocyte and microvilli dimensions by 10 and 20%, respectively, within 48 h. Post-hatch, enterocytes and microvilli were 20% longer in Gln-treated chicks. Correspondingly, Gln stimulation significantly upregulated mRNA expression of brush border nutrient transporters PepT-1 and SGLT-1 and tight junction proteins TJP-1 and TJP-2, before and after hatch (P < 0.05). Since GLP-2 signaling from intestinal L-cells is associated with enterocyte growth, functionality and integrity, we examined the effects of Gln stimulation on mRNA expression of key hormones and receptors within this enteroendocrine pathway and found significant increases in GLP-2R, IGF-1 and IGF-1R expression before and after hatch (P < 0.05). In conclusion, our findings link primary nutrient stimulation in the developing small intestine with enterocyte morphological and functional maturation and enteroendocrine signaling.
Characteristics of clusters with contrasting relationships between central sensitization-related symptoms and pain
Authors: Koga Masayuki , Shigetoh Hayato , Tanaka Yoichi , Morioka Shu 
Published: February 2022

AbstractThe central sensitization inventory (CSI) evaluates the central sensitization (CS)-related symptoms associated with increased pain sensitivity. However, the CSI includes items that are not directly related to pain. In this study, 146 patients with pain were classified into subgroups by k-means cluster analysis based on the short form of the central sensitization inventory (CSI9) and pain scores. In addition, inter-group and multiple comparisons were performed to examine the characteristics of each group. As a result of this study, there were three subgroups (clusters 1, 2, and 3) in which the CSI9 and pain intensity were both low, moderate, and high, and one subgroup (cluster 4) in which only CSI9 was high and pain intensity was low. Two subgroups with high CSI9 scores but contrasting pain intensities (clusters 3 and 4) were extracted; the pattern of CS-related symptoms in these two groups was very similar, with no differences in most of the non-pain factors. It is necessary to consider these points when interpreting the clinical condition of a patient with pain when using the assessment of CS-related symptoms.
Influence of heterogeneous age-group contact patterns on critical vaccination rates for herd immunity to SARS-CoV-2
Authors: Saldaña Joan , Scoglio Caterina 
Published: February 2022

AbstractCurrently, several western countries have more than half of their population fully vaccinated against COVID-19. At the same time, some of them are experiencing a fourth or even a fifth wave of cases, most of them concentrated in sectors of the populations whose vaccination coverage is lower than the average. So, the initial scenario of vaccine prioritization has given way to a new one where achieving herd immunity is the primary concern. Using an age-structured vaccination model with waning immunity, we show that, under a limited supply of vaccines, a vaccination strategy based on minimizing the basic reproduction number allows for the deployment of a number of vaccine doses lower than the one required for maximizing the vaccination coverage. Such minimization is achieved by giving greater protection to those age groups that, for a given social contact pattern, have smaller fractions of susceptible individuals at the endemic equilibrium without vaccination, that is, to those groups that are more vulnerable to infection.
A testis-expressing heme peroxidase HPX12 regulates male fertility in the mosquito Anopheles stephensi
Authors: Kumari Seena , Tevatiya Sanjay , Rani Jyoti , Das De Tanwee , Chauhan Charu , Sharma Punita , Sah Rajkumar , Singh Shailja , Pandey Kailash C. , Pande Veena , Dixit Rajnikant 
Published: February 2022

AbstractIn vertebrates dysregulation of the antioxidant defense system has a detrimental impact on male fertility and reproductive physiology. However, in insects, especially mosquitoes the importance of sperm quality has been poorly studied. Since long-term storage of healthy and viable sperm earmarks male reproductive competency, we tested whether the heme peroxidase, a member of antioxidant enzyme family proteins, and abundantly expressed in the testis, also influence male fertility in the mosquito An. stephensi. Here, we show that a heme peroxidase 12 (HPX12), is an important cellular factor to protect the sperms from oxidative stress, and maintains semen quality in the male mosquito reproductive organ. We demonstrate that knockdown of the HPX12 not only impairs the sperm parameters such as motility, viability but also causes a significant down-regulation of MAG expressing transcripts such as ASTEI02706, ASTEI00744, ASTEI10266, likely encoding putative Accessory gland proteins. Mating with HPX12 knockdown male mosquitoes, resulted in ~ 50% reduction in egg-laying, coupled with diminished larval hatchability of a gravid female mosquito. Our data further outlines that increased ROS in the HPX12 mRNA depleted mosquitoes is the ultimate cause of sperm disabilities both qualitatively as well as quantitatively. Our data provide evidence that testis expressing AsHPX12 is crucial for maintaining optimal homeostasis for storing and protecting healthy sperms in the male mosquito’s reproductive organs. Since, high reproductive capacity directly influences the mosquito population, manipulating male mosquito reproductive physiology could be an attractive tool to combat vector-borne diseases.