bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated generation of cerebral blood flow and arterial transit time maps from multiple delay arterial spin‐labeled MRI
Authors: Luciw Nicholas J. , Shirzadi Zahra , Black Sandra E. , Goubran Maged , MacIntosh Bradley J. 
Published: February 2022

PurposeDevelop and evaluate a deep learning approach to estimate cerebral blood flow (CBF) and arterial transit time (ATT) from multiple post‐labeling delay (PLD) ASL MRI.MethodsASL MRI were acquired with 6 PLDs on a 1.5T or 3T GE system in adults with and without cognitive impairment (N = 99). Voxel‐level CBF and ATT maps were quantified by training models with distinct convolutional neural network architectures: (1) convolutional neural network (CNN) and (2) U‐Net. Models were trained and compared via 5‐fold cross validation. Performance was evaluated using mean absolute error (MAE). Model outputs were trained on and compared against a reference ASL model fitting after data cleaning. Minimally processed ASL data served as another benchmark. Model output uncertainty was estimated using Monte Carlo dropout. The better‐performing neural network was subsequently re‐trained on inputs with missing PLDs to investigate generalizability to different PLD schedules.ResultsRelative to the CNN, the U‐Net yielded lower MAE on training data. On test data, the U‐Net MAE was 8.4 ± 1.4 mL/100 g/min for CBF and 0.22 ± 0.09 s for ATT. A significant association was observed between MAE and Monte Carlo dropout‐based uncertainty estimates. Neural network performance remained stable despite systematically reducing the number of input images (i.e., up to 3 missing PLD images). Mean processing time was 10.77 s for the U‐Net neural network compared to 10 min 41 s for the reference pipeline.ConclusionIt is feasible to generate CBF and ATT maps from 1.5T and 3T multi‐PLD ASL MRI with a fast deep learning image‐generation approach.
Exploratory evaluation of baseline cognition as a predictor of perceived benefit in a study of behavioral therapy for urinary incontinence in Parkinson disease
Authors: Chang Phat L. , Goldstein Felicia C. , Burgio Kathryn L. , Juncos Jorge L. , McGwin Gerald , Muirhead Lisa , Markland Alayne D. , Johnson Theodore M. , Vaughan Camille P. 
Published: February 2022

AbstractAimsWhile behavior‐based pelvic floor muscle exercise therapy is an effective treatment for overactive bladder in Parkinson's disease (PD) patients, cognitive function may be a predictor of rehabilitation outcomes.MethodsIn a planned exploratory analysis, participants who had a Montreal Cognitive Assessment (MoCA) with a score ≥18 who were randomized in a clinical trial to behavioral treatment were classified by perceived improvement (Benefit vs. No Benefit) as reported on a validated Satisfaction and Benefit Questionnaire. General cognition (MoCA), motor procedural learning (Serial reaction time task), verbal memory (Buschke delayed recall), spatial memory (Nonverbal/Spatial selective reminding test), and working memory (Wisconsin card sorting task) were compared between the two groups using Wilcoxon rank‐sum test.ResultsOf the 26 participants randomized to behavioral treatment (70% male, mean age 71 ± 6.1 years), 22 participants (85%) reported Benefit and four reported No Benefit. General cognition, motor procedural learning, verbal memory, spatial memory, and working memory did not differ between these groups. While the difference between the time to complete the final practiced series and the random series of the Serial Reaction Time Task (SRTT) was statistically similar between the groups, the Benefit group performed the random sequence more quickly (567.0 ± 136.5 ms) compared to the No Benefit group (959.4 ± 443.0 ms; p = 0.03) and trended toward faster performance in the final practiced series.ConclusionsPerceived benefit from behavioral treatment for overactive bladder was not associated with measures of baseline cognition other than faster completion of the SRTT. This is noteworthy because many behavior‐based therapy studies exclude participants with mild cognitive impairment. Additional studies may evaluate if domain‐specific cognitive function, particularly the assessment of implicit memory, could lead to individualized behavioral therapy recommendations.
Sacral neuromodulation in patients with detrusor underactivity: Is biological sex an indicator?
Authors: Onur Rahmi , Tayebi Sona , Salehi‐Pourmehr Hanieh , Jahantabi Elham , Perrouin‐Verbe Marie‐Aimee , Naseri Changiz , Hajebrahimi Sakineh , Hashim Hashim 
Published: February 2022

AbstractObjectivesThis study aimed to report sacral neuromodulation (SNM) outcomes in detrusor underactivity (DU).MethodsA multicentric, multinational, retrospective case series was conducted between March 2017 and June 2021 in three different referral centers. Initial test phase stimulation included either a percutaneous nerve evaluation (PNE) or an advanced lead evaluation test phase (ALTP) before permanent SNM implantation. The test phases were performed under local anesthesia, either in the outpatient (PNE) or operating room (ALTP), in the prone position, which was implanted in the third or fourth sacral foramina under fluoroscopic guidance. Patients with favorable response to the initial test phase during the first 2 weeks underwent the implantable pulse generator (IPG) implantation (Medtronic neurostimulation generator device InterStim™). Favorable response was defined as ≥ 50% improvement in symptoms, frequency of clean intermittent catheterization (CIC) and/or decrease in postvoid residual (PVR), increase in voided volume, or improvement in bladder voiding efficiency (BVE) based on the bladder diary.ResultsFifty‐eight patients were recruited with a mean age of 39.95 ± 15.28 years. Among the 58 cases, 36 (62.1%) patients responded to the initial stage. Of these, 12 patients (30.8%) with non‐neurogenic etiology and nine patients (52.9%) with neurologic etiology did not respond to the initial test phase; thus, they did not undergo full implantation (p = 0.141). Voided volume, PVR, and the median maximum flow rate (Qmax) improved significantly (p < 0.001) in both sexes; however, there was no statistical difference between both genders. Most female cases (78.3%), and nearly half of the men (51.4%), responded to the test phase and were candidates for the IPG phase. Among the 35 cases who underwent IPG, 27 patients (72.2% of males, and 77.8% of females; p = 0.700) had a favorable response to IPG. 46.6% of patients had a successful outcome at the end of the study.ConclusionThis multicentric study showed that SNM effectively and safely provided symptom improvement in refractory DU in males similar to females which is an important finding as previously it has been suggested that SNM works better in nonobstructive urinary retention in women and not in men.
Exploratory safety study of an umbilical cord derived urethral sling in bilateral pudendal nerves injury‐induced urinary incontinence in female rats
Authors: Pinar Ugo , Grossetete Florine , Barnouin Laurence , Chartier‐Kastler Emmanuel 
Published: February 2022

AbstractPurposeMid‐urethral slings are the standard treatment for women with refractory stress urinary incontinence (SUI) but are at risk of infection or erosion due to host−prothesis interaction. In this proof‐of‐concept study, we aimed at evaluating umbilical vessel sling (UVS) in incontinent female rats.Material and MethodsUVS was extracted from human umbilical cord lining and was placed on female rats who underwent bilateral pelvic nerve injury (PNI) to reproduce SUI (Group 3, N = 10). Two control groups were also studied: rats with no PNI (Group 1, N = 4) and rats with PNI but no UVS (Group 2, N = 10). Micturition calendar was frequently recorded using a metabolic cage, and leak point pressure (LPP) test was performed on Day 28. After the LPP test, rats were euthanized, and bladder/urethra were collected for histopathological analysis.ResultsOverall, 24 rats were included, of whom 10 had both PNI and UVS placement. Compared with Group 2, Group 3 had increased maximal LPP but the difference did not reach significance (respectively 21.8 ± 2.1 mmHg vs. 28.4 ± 4.1 mmHg, p = 0.2). Micturition frequencies were similar between the groups. Total voided volume was higher in Group 3 at the end of the study compared with Group 2 (12.5 ± 1.1 ml vs. 9.4 ± 0.6 ml, respectively, p < 0.05). Histopathological findings evidenced a good local tolerance and a moderate to high tissue integration of the UVS.ConclusionsBiological sling derived from human umbilical vessel could be safely placed with a slight improvement of LPP in a population of rats who had bilateral PNI without major modification of micturition calendar. UVS could be a promising biomaterial in the management of SUI in women. Clinical studies are needed.
A brief review of applied psychology in China
Authors: Wang Richu , Han Buxin , Zhang Kan 
Published: February 2022

AbstractPsychology in China has a long past, but a rather short history. Modern psychology was introduced to China in the early 20th century soon, psychology as a scientific discipline was established when the teaching, research, and academic exchanges began. Specifically, applied psychology was established until the last decade of the 20th century; however, the past 30 years have witnessed the fast growth of applied psychology in China. In this article, we briefly introduce the history of psychology in China, its establishment as a discipline and a profession, and present some applications of psychology in the domains of public mental health as well as in educational and organizational settings.
Precision medicine in mood disorders
Authors: Serretti Alessandro 
Published: February 2022

AbstractThe choice of the most appropriate psychoactive medication for each of our patients is always a challenge. We can use more than 100 psychoactive drugs in the treatment of mood disorders, which can be prescribed either alone or in combination. Response and tolerability problems are common, and much trial and error is often needed before achieving a satisfactory outcome. Precision medicine is therefore needed for tailoring treatment to optimize outcome. Pharmacological, clinical, and demographic factors are important and informative, but biological factors may further inform and refine prediction. Twenty years after the first reports of gene variants modulating antidepressant response, we are now confronted with the prospect of routine clinical pharmacogenetic applications in the treatment of depression. The scientific community is divided into two camps: those who are enthusiastic and those who are skeptical. Although it appears clear that the benefit of existing tools is still not completely defined, at least in the case of central nervous system gene variants, this is not the case for metabolic gene variants, which is generally accepted. Cumulative scores encompassing many variants across the entire genome will soon predict psychiatric disorder liability and outcome. At present, precision medicine in mood disorders may be implemented using clinical and pharmacokinetic factors. In the near future, a genome‐wide composite genetic score in conjunction with clinical factors within each patient is the most promising approach for developing a more effective way to target treatment for patients suffering from mood disorders.
Investigating the effects of perceived student gender on primary school teachers' recognition of autism
Authors: Ward Tanwen B. , Curtis Cate , Seehagen Sabine 
Published: February 2022

AbstractRecent research indicates that autism is under‐recognized in girls and women. The current study investigated whether the gender‐based assumptions of teaching staff impact the identification of autism. A survey was completed by 249 primary school teaching staff. After reading a vignette describing the behavior of a hypothetical child whose gender was randomly assigned, participants answered questions regarding possible reasons for the behavior described, including mental health and disability diagnoses and their confidence in their chosen answers. The gender of the described child was not found to have an impact on the likelihood of choosing autism as a potential diagnosis, suggesting that the participants did not make gender‐based assumptions about autism characteristics. Higher qualified teachers were less confident in their answers than those with lower or no qualifications. Teachers may have more nuanced understandings of the complexities of autism than had been expected. Further research into the effect of gender on autism identification is needed.
The growth and development of research on personality disorders: A bibliometric study
Authors: Reis Taylor , Gekker Márcio , Land Marcelo Gerardin Poirot , Mendlowicz Mauro Vitor , Berger William , Luz Mariana Pires , Vilete Liliane , Figueira Ivan , Araújo Alexandre Xavier Gomes 
Published: February 2022

AbstractThis study objective was to investigate publication trends on personality disorders (PD) and to identify patterns of historical development. Publication rates were determined using the Results by Year Timeline feature of PubMed. Time series autoregressive integrated moving average models were used to analyse the publication rates for PDs in quinquennial periods beginning in 1980 and ending in 2019 and to predict the number of publications in the 2024–2029 period. More than 300 articles on antisocial and borderline PD are being published each year, and the models suggest an accelerating growth rate. Approximately 100 articles are being published on average every year on schizotypal PD, and the regression model indicates linear growth in the near future. The mean number of publications per year for obsessive–compulsive, narcissistic and avoidant PDs is in the range of 10–30 with the corresponding models indicating linear growth. Fewer than 10 articles are being published each year on dependent, paranoid, histrionic and schizoid PD, whereas dependent PD shows modest growth and paranoid PD rates tended to stability, histrionic and schizoid PD exhibit declining rates. Personality disorders are a group of conditions with diverse etiological, prognostic, therapeutic, legal, research, social and cultural implications that influence publication rates.
Fischer and Schrock carbene complexes in the light of global and local electrophilicity‐based descriptors
Authors: Patra Shanti Gopal , Jha Ruchi , Mondal Himangshu , Chattaraj Pratim Kumar 
Published: February 2022

AbstractThe carbon atom (carbene) of Fischer and Schrock complexes are electrophilic and nucleophilic, respectively. The reactivity index electrophilicity is a global reactivity parameter and can tell only about the total electrophilicity of the complexes. To differentiate between the reactivity patterns of these two carbenes, the philicity and multiphilic descriptor are calculated. In Fischer complexes, it is found that the philicity of the nucleophilic attack (
) is higher than that of philicity of the electrophilic attack (
) implying the electrophilic nature. A reverse order is found in the Schrock complex pointing nucleophilic character. The multiphilic descriptor (ΔωC =
−
) is found to be positive in Fischer but negative in Schrock leading to the same conclusion. Fischer carbene complexes having general formula (CO)5Cr═CH‐R (R = CH3, Ph, CCH, CH═CH2, OCH3, OH, NHCH3, and NH2) the order of
and ΔωC better describe the trend. The trend has been justified through energy decomposition in the purview natural orbital for chemical valence (EDA‐NOCV) analysis owing to the π contribution from the R group. The change in the reactivity patterns along the intrinsic reaction coordinate of two representative reactions is plotted. This way of understanding the reactivity parameters would help experimental chemists to predict the catalytic application of carbene complexes of transition metal without the classification of Fischer and Schrock type.
Effect of sacrificial bond on molecular dynamics and rheological behavior of hybrid butadiene‐styrene‐vinylpyridine rubber vulcanizates with reversible sacrificial network
Authors: Hu Rongyan , Zhao Shunjie , Chen Feng , Shangguan Yonggang , Zheng Qiang 
Published: February 2022

AbstractDue to the improvement of strength and toughness at the same time, construction of reversible sacrificial bond network has attracted extensive attention to realize the high performance and functionalization of rubber materials. However, the research on the viscoelastic behavior of vulcanized rubber with reversible sacrificial bond network lags behind seriously. In this work relaxation kinetics, linear rheological behavior and nonlinear rheological behavior of hybrid crosslinked butadiene‐styrene‐vinylpyridine rubber (VPR) with reversible Zn2+‐pyridine coordination bond were investigated in detail. It was found that, the tensile results under small strain were more conducive to reflect the contribution of sacrificial bond after sequential tensile‐recovery process than those under large strain. Although sacrificial bond could affect both G' and G" at low temperature, the contribution of it to G" was more prominent. When the temperature was higher than the dissociation temperature of Zn2+‐pyridine coordination bond, the sacrificial bond could only affect G", which was due to the fact that the pyridine group was equivalent to the graft on VPR backbone and acted as dangling chain. In addition, the destruction and reconstruction of coordination bond was the dominant factor in modulus recovery.
A pediatric hospital‐wide asthma severity score: Reliability and effectiveness
Authors: McBride Sarah C. , McCarty Kendall , Wong Jackson , Baskin Marc , Currier Denise , Chiang Vincent W. 
Published: February 2022

AbstractBackgroundAsthma is a leading cause of pediatric hospitalization in the United States. Children hospitalized with asthma are often managed in different care settings during hospitalization, posing challenges to accurate communication among care providers about illness severity. Our objective was to study the feasibility, reliability, and safety of a new pediatric hospital‐wide asthma severity score (HASS) across different care units within a single tertiary‐care pediatric center.Methods150 patients between the ages of 2 and 18 years hospitalized with a principal diagnosis of status asthmaticus were included in this study. Study patients were followed from the time of initial triage in the emergency department until the time of medical readiness for discharge. Rates of medical errors, early transfers to a higher level of care and medically indicated hospital length of stay (LOS) were compared between 75 patients before and 75 patients after widespread implementation of the HASS using retrospective chart review and anonymous staff reporting. Interrater reliability was determined by collecting independent HASS scores from blinded staff members after tandem or simultaneous patient assessment.ResultsInterrater reliability among untrained staff members using the HASS was high. Hospital LOS, rates of adverse events, medical errors, and early transfer to a higher level of care were not significantly different before and after widespread HASS implementation.ConclusionThe HASS is a reliable asthma severity tool that can be used throughout hospitalization and among multiple clinical providers to trend clinical progress and optimize communication, particularly during times of care handoffs.
Do clinimetric properties of LCI change after correction of signal processing?
Authors: Frauchiger Bettina S. , Oestreich Marc‐Alexander , Wyler Florian , Monney Nathalie , Willers Corin , Yammine Sophie , Latzin Philipp 
Published: February 2022

AbstractBackgroundThe recently described sensor‐crosstalk error in the multiple‐breath washout (MBW) device Exhalyzer D (Eco Medics AG) could highly influence clinimetric properties and the current interpretation of MBW results. This study reanalyzes MBW data from clinical routine in the corrected software version Spiroware® 3.3.1 and evaluates the effect on outcomes.MethodsWe included nitrogen‐MBW data from healthy children and children with cystic fibrosis (CF) from previously published trials and ongoing cohort studies. We specifically compared lung clearance index (LCI) analyzed in Spiroware 3.2.1 and 3.3.1 with regard to (i) feasibility, (ii) repeatability, and (iii) validity as outcome parameters in children with CF.Results(i) All previously collected measurements could be reanalyzed and resulted in unchanged feasibility in Spiroware 3.3.1. (ii) Short‐ and midterm repeatability of LCI was similar in both software versions. (iii) Clinical validity of LCI remained similar in Spiroware 3.3.1; however, this resulted in lower values. Discrimination between health and disease was comparable between both software versions. The increase in LCI over time was less pronounced with 0.16 LCI units/year (95% confidence interval [CI] 0.08; 0.24) versus 0.30 LCI units/year (95% CI 0.21; 0.38) in 3.2.1. Response to intervention in children receiving CF transmembrane conductance‐modulator therapy resulted in a comparable improvement in LCI, in both Spiroware versions.ConclusionOur study confirms that clinimetric properties of LCI remain unaffected after correction for the cross‐sensitivity error in Spiroware software.
iTRAQ and two‐dimensional‐LC‐MS/MS reveal NAA10 is a potential biomarker in esophageal squamous cell carcinoma
Authors: Wang Dong , Chen Jinyan , Han Junyong , Wang Kun , Fang Weimin , Jin Jingjun , Xue Shijie 
Published: February 2022

AbstractPurposeEsophageal squamous cell carcinoma (ESCC) is one of the most common and serious malignancies in China. However, the exact mechanisms of tumor progression are still unclear. Thus, identifying biomarkers for early diagnosis, prognostic and recurrence assessment of ESCC is necessary.Experimental DesigniTRAQ was used to identify differentially expressed proteins (DEPs) in tumor tissues. N‐alpha‐acetyltransferase 10 (NAA10) is confirmed and validated by immunohistochemistry and western blotting. Furthermore, the effects of NAA10 on TE‐1 cells were detected by CCK‐8, colonies formation, anchorage‐independent growth in soft agar, migration and transwell assays. LinkedOmics was used to identify differential gene expression with NAA10 and to analyze Gene Ontology and KEGG pathways. Coexpression gene network was conducted by the STRING database and Cytoscape software (MCODE plug‐in).Results516 DEPs were identified. NAA10 was downregulated in cancer tissues and selected for further confirmed. Furthermore, NAA10 can inhibit proliferation and tumorigenesis, and suppress migration and invasion of TE‐1. Functional network analysis suggested that NAA10 regulates the ribosome pathways involving eight ribosomal proteins.Conclusion and Clinical RelevanceThese findings clearly demonstrated that NAA10 is a tumor suppressor and novel potential biomarker for ESCC, laying a foundation for further study of the role of NAA10 in carcinogenesis.