bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cork derived laser-induced graphene for sustainable green electronics
Authors: Silvestre Sara L , Pinheiro Tomás , Marques Ana C , Deuermeier Jonas , Coelho João , Martins Rodrigo , Pereira Luís , Fortunato Elvira 
Published: September 2022

Abstract
The demand for smart, wearable devices has been dictating our daily life with the evolution of integrated miniaturized electronics. With technological innovations, comes the impactful human footprint left on the planet’s ecosystems. Therefore, it is necessary to explore renewable materials and sustainable methodologies for industrial processes. Here, an eco-friendly approach to producing flexible electrodes based on a single-step direct laser writing is reported. A 1.06 µm wavelength fiber laser was used for the first time to produce porous three-dimensional laser-induced graphene (LIG) on an agglomerated cork substrates. The obtained material exhibits the typical Raman spectra, along with an exceptionally low sheet resistance between 7.5 and 10 ohm sq−1. LIG on cork high electrical conductivity and the friendliness of the used production method, makes it an interesting material for future technological applications. To show its applicability, the production of planar micro-supercapacitors was demonstrated, as a proof of concept. Electrochemical performance studies demonstrate that LIG interdigitated electrodes, using PVA-H2SO4 electrolyte, achieve an area capacitance of 1.35 mF cm−2 (103.63 mF cm−3) at 5 mV s−1 and 1.43 mF cm−2 (109.62 mF cm−3) at 0.1 mA cm−2. In addition, devices tested under bending conditions exhibit a capacitance of 2.20 mF cm−2 (169.22 mF cm−3) at 0.1 mA cm−2. Here, showing that these electrodes can be implemented in energy storage devices, also successfully demonstrating LIG promising application on innovative, green, and self-sustaining platforms.
Quad-port electromagnetic band gap (EBG)—backed non-isomorphic multiple-input-multiple-output (MIMO) antenna for wearable applications
Authors: Govindan Thennarasi , Palaniswamy Sandeep Kumar , Kanagasabai Malathi , Velan Sangeetha , Kumar Sachin , Rao Thipparaju Rama 
Published: September 2022

Abstract
This paper presents the design of a quad-port orthogonal ultra-wideband (UWB) monopole antenna backed with an electromagnetic band gap (EBG) structure. The EBG structure provides band stop/band reject characteristics in the entire UWB range. The overall dimension of the diversity antenna is 70 × 70 × 1

m

m

3

(

0.68

λ
0

×
0.68

λ
0

×
0.01

λ
0

), where

λ
0

corresponds to the lowest resonating frequency. The proposed monopole antenna offers good impedance bandwidth of 8.67 GHz (2.93–11.6 GHz). The estimated diversity characterization metrics observed over the obtained frequency range are envelope correlation coefficient < 0.11, mean effective gain (MEG) < 1 dB, effective diversity gain < 9.88 dB, apparent diversity gain < 9.99 dB, channel capacity loss < 0.19 bits (s Hz)−1, and total active reflection coefficient < −20.95 dB. Also, specific absorption rate analysis is realized for the antenna in seven different tissues of the body (forehead, forearm, upper arm, chest, abdomen, thigh and lower leg) to check radiation exposure towards the human body.
Mechanism of NH3 gas sensing by SnO2/PANI nanocomposites: charge transport and temperature dependence study
Authors: Gautam Shivam Kumar , Gokhale Nachiket Aashish , Panda Siddhartha 
Published: September 2022

Abstract
Metal oxide-Polyaniline (PANI) nanocomposites have shown improved gas sensing characteristics that can be attributed to the formation of a p–n junction between the n-type metal oxide and the p-type PANI. The charge transport, grain boundary depletion region, and intragrain resistance are studied to understand the gas sensing mechanism of pristine metal oxide gas sensors. However, gas sensing mechanisms for metal-oxide/PANI nanocomposites have not been studied extensively. In this work, we have studied the gas sensing mechanism of SnO2/PANI nanocomposites using electrochemical impedance spectroscopy, and temperature dependent gas sensing experiments. Well-defined SnO2 nanoclusters were observed in the PANI matrix. The n-type SnO2 was covered by p-type PANI, and a depletion region was formed at the interface. The presence of the p–n junction depletion region was confirmed by impedance spectroscopy. The polarons in PANI were trapped by NH3 leading to a change in the width of the conducting path due to rearrangement of charge carriers along the depletion region. The change in the conduction path, along with the trapped polarons, enhanced the sensor response. For higher loadings of SnO2, the depletion region was deformed, and the sensor response decreased due to non-uniform boundaries. 1 wt% SnO2 with respect to aniline precursor in in situ synthesis showed the best response of 37.8% for 100 ppm NH3 at 35 °C. The response was stable for low humidity levels up to 51%RH. The response increased for higher humidity levels. The sensor response increased from 0.17 to 2.99 upon bending 1000 times at 7.8 mm diameter due to cracks in the surface. The sensor showed only 10% variation in response after 9 months.
Universal approach to sending-or-not-sending twin field quantum key distribution
Authors: Hu Xiao-Long , Jiang Cong , Yu Zong-Wen , Wang Xiang-Bin 
Published: September 2022

Abstract
We present a universal approach to sending-or-not-sending (SNS) protocol of twin-field quantum key distribution with the method of actively odd parity pairing. In this improved protocol, the code bits are not limited to heralded events in time windows participated by pulses of intensity μ

z
and vacuum. All kinds of heralded events can be used for code bits to distill the final keys. The number of intensities (3 or 4) and the kinds of heralded events for code bits are automatically chosen by the key rate optimization itself. Numerical simulation shows that the key rate rises drastically in typical settings, up to 80% improvement compared with the prior results. Also, larger intensity value can be used for decoy pulses. This makes the protocol more robust in practical experiments.
Nitrogen Inventories and Nitrogenase Expression Rates of a Drywood and a Subterranean Termite
Authors: Mullins Aaron , Scheffrahn Rudolf , Su Nan-Yao 
Published: September 2022

Abstract
Recent research has shown that a subterranean termite (Coptotermes formosanus Shiraki) is dependent on dietary nitrogen in order to fulfill it's nitrogen requirements for colony growth and development. Crypototermes brevis (Walker) was chosen as a model for comparison, as it has no access to dietary nitrogen outside of it’s wood diet. A full nitrogen inventory before and after colony growth was conducted in order to determine the species’ dependence on atmospheric N2 fixation. In addition, an expression assay was conducted for a gene encoding a nitrogenase subunit (nifH). Nitrogenase expression was then compared between C. formosanus and Cr. brevis. Results showed that N2 fixation was an important source of nitrogen acquisition for Cr. brevis, and nitrogenase expression was approximately four-fold higher in Cr. brevis than in C. formosanus. The nitrogenase assay used in this study is proposed as a potential tool to measure dependence on N2 fixation versus dietary nitrogen roles in diverse species of termite.
Evolutionary history of marginal habitats regulates the diversity of tree communities in the Atlantic Forest
Authors: Massante Jhonny Capichoni , Gastauer Markus 
Published: September 2022

AbstractBackground and AimsThe Atlantic Forest biodiversity hotspot is a complex mosaic of habitat types. However, the diversity of the rain forest at the core of this complex has received far more attention than that of its marginal habitats, such as cloud forest, semi-deciduous forest or restinga. Here, we investigate broad-scale angiosperm tree diversity patterns along elevation gradients in the south-east Atlantic Forest and test if the diversity of marginal habitats is shaped from the neighbouring rain forest, as commonly thought.MethodsWe calculated phylogenetic indices that capture basal [mean pairwise phylogenetic distance (MPD)] and terminal [mean nearest taxon distance (MNTD)] phylogenetic variation, phylogenetic endemism (PE) and taxonomic and phylogenetic beta diversity (BD and PBD) for 2074 angiosperm tree species distributed in 108 circular sites of 10 km diameter across four habitat types i.e. rain forest, cloud forest, semi-deciduous forest and coastal vegetation known as restinga. We then related these metrics to elevation and environmental variables.Key ResultsCommunities in wetter and colder forests show basal phylogenetic overdispersion and short phylogenetic distances towards the tips, respectively. In contrast, communities associated with water deficit and salinity show basal phylogenetic clustering and no phylogenetic structure toward the tips. Unexpectedly, rain forest shows low PE given its species richness, whereas cloud and semi-deciduous forests show unusually high PE. The BD and PBD between most habitat types are driven by the turnover of species and lineages, except for restinga.ConclusionsOur results contradict the idea that all marginal habitat types of the Atlantic Forest are sub-sets of the rain forest. We show that marginal habitat types have different evolutionary histories and may act as ‘equilibrium zones for biodiversity’ in the Atlantic Forest, generating new species or conserving others. Overall, our results add evolutionary insights that reinforce the urgency of encompassing all habitat types in the Atlantic Forest concept.
I2b2-etl: Python application for importing electronic health data into the informatics for integrating biology and the bedside platform
Authors: Wagholikar Kavishwar B , Ainsworth Layne , Zelle David , Chaney Kira , Mendis Michael , Klann Jeffery , Blood Alexander J , Miller Angela , Chulyadyo Rupendra , Oates Michael , Gordon William J , Aronson Samuel J , Scirica Benjamin M , Murphy Shawn N 
Published: September 2022

Abstract

Motivation
The i2b2 platform is used at major academic health institutions and research consortia for querying for electronic health data. However, a major obstacle for wider utilization of the platform is the complexity of data loading that entails a steep curve of learning the platform’s complex data schemas. To address this problem, we have developed the i2b2-etl package that simplifies the data loading process, which will facilitate wider deployment and utilization of the platform.

Results
We have implemented i2b2-etl as a Python application that imports ontology and patient data using simplified input file schemas and provides inbuilt record number de-identification and data validation. We describe a real-world deployment of i2b2-etl for a population-management initiative at MassGeneral Brigham.

Availability and implementation
i2b2-etl is a free, open-source application implemented in Python available under the Mozilla 2 license. The application can be downloaded as compiled docker images. A live demo is available at https://i2b2clinical.org/demo-i2b2etl/ (username: demo, password: Etl@2021).

Supplementary information
Supplementary data are available at Bioinformatics online.
Evolutionary history of theAsplenium scolopendriumcomplex (Aspleniaceae), a relictual fern with a northern pan-temperate disjunct distribution
Authors: Heo Namjoo , Lomolino Mark V , Watkins James E , Yun Seona , Weber-Townsend Josh , Fernando Danilo D 
Published: September 2022

AbstractAsplenium scolopendrium is distributed in northern temperate forests with many global biogeographic disjunctions. The species complex of A. scolopendrium has been generated by spatial segregation coupled with divergent evolution. We elucidated the biogeographic history of the A. scolopendrium complex by exploring its origin, dispersal and evolution, thus providing insights into the evolutionary history of the Tertiary floras with northern pan-temperate disjunct distributions. The results revealed that all infraspecific taxa descended from a widely distributed common ancestor in the Northern Hemisphere. This pan-temperate ancestral population formed by unidirectional westward dispersal from European origins primarily during the Early Eocene when the Earth’s climate was much warmer than today. The splitting of European, American and East Asian lineages occurred during the Early Miocene due to geo-climatic vicariances. Polyploidy events in the American ancestral populations created additional reproductive barriers. The star-shaped haplotypes in each continent indicated that local disjunctions also led to derived genotypes with potential to diverge into different taxa. This intracontinental lineage splitting is likely related to latitudinal range shift and habitat fragmentation caused by glacial cycles and climate change during the Pleistocene. The evolutionary history of the A. scolopendrium complex supported the Boreotropical hypothesis exhibiting range expansion during the Early Eocene Climatic Optimum.
Evolution of the rostral scale and mimicry in the genusXenodonBoie, 1826 (Serpentes: Dipsadidae: Xenodontinae)
Authors: Cabral Hugo , Cacciali Pier , Santana Diego José 
Published: September 2022

AbstractSnakes are a stimulating life form from an evolutionary perspective. Despite the basic morphological body shape (limbless, with a tubular body), these vertebrates are extremely diverse. The Neotropical region is one of the most diverse regions for snakes in the world, with &gt;650 known species. Within this great diversity, the genus Xenodon includes 12 species with interesting adaptations to terrestrial and semi-fossorial habitats. Members of this genus are mostly diurnal and terrestrial, feed mainly on anurans and exhibit Batesian mimicry of venomous snakes of the genera Bothrops or Micrurus. Here, through phylogenetic analysis and ancestral state estimation, we explore the evolution of the rostral scale and mimicry within the genus Xenodon. Our results suggest that the ancestral lineage of Xenodon had a rounded rostral scale and exhibited Bothrops mimicry. The evolution of the rostral scale in Xenodon might be related to abiotic factors, as an adaptation for open and forested habitats, and mimicry is likely to be related to biotic factors, as a defensive strategy resembling those of venomous snakes.
Targeted transcript analysis in muscles from patients with genetically diverse congenital myopathies
Authors: Bachmann Christoph , Franchini Martina , Van den Bersselaar Luuk R , Kruijt Nick , Voermans Nicol C , Bouman Karlijn , Kamsteeg Erik-Jan , Knop Karl Christian , Ruggiero Lucia , Santoro Lucio , Nevo Yoram , Wilmshurst Jo , Vissing John , Sinnreich Michael , Zorzato Daniele , Muntoni Francesco , Jungbluth Heinz , Zorzato Francesco , Treves Susan 
Published: September 2022

AbstractCongenital myopathies are a group of early onset muscle diseases of variable severity often with characteristic muscle biopsy findings and involvement of specific muscle types. The clinical diagnosis of patients typically relies on histopathological findings and is confirmed by genetic analysis. The most commonly mutated genes encode proteins involved in skeletal muscle excitation–contraction coupling, calcium regulation, sarcomeric proteins and thin–thick filament interaction. However, mutations in genes encoding proteins involved in other physiological functions (for example mutations in SELENON and MTM1, which encode for ubiquitously expressed proteins of low tissue specificity) have also been identified. This intriguing observation indicates that the presence of a genetic mutation impacts the expression of other genes whose product is important for skeletal muscle function. The aim of the present investigation was to verify if there are common changes in transcript and microRNA expression in muscles from patients with genetically heterogeneous congenital myopathies, focusing on genes encoding proteins involved in excitation–contraction coupling and calcium homeostasis, sarcomeric proteins, transcription factors and epigenetic enzymes. Our results identify RYR1, ATPB2B and miRNA-22 as common transcripts whose expression is decreased in muscles from congenital myopathy patients. The resulting protein deficiency may contribute to the muscle weakness observed in these patients. This study also provides information regarding potential biomarkers for monitoring disease progression and response to pharmacological treatments in patients with congenital myopathies.
Decoding sounds depicting hand–object interactions in primary somatosensory cortex
Authors: Bailey Kerri M , Giordano Bruno L , Kaas Amanda L , Smith Fraser W 
Published: September 2022

AbstractNeurons, even in the earliest sensory regions of cortex, are subject to a great deal of contextual influences from both within and across modality connections. Recent work has shown that primary sensory areas can respond to and, in some cases, discriminate stimuli that are not of their target modality: for example, primary somatosensory cortex (SI) discriminates visual images of graspable objects. In the present work, we investigated whether SI would discriminate sounds depicting hand–object interactions (e.g. bouncing a ball). In a rapid event-related functional magnetic resonance imaging experiment, participants listened attentively to sounds from 3 categories: hand–object interactions, and control categories of pure tones and animal vocalizations, while performing a one-back repetition detection task. Multivoxel pattern analysis revealed significant decoding of hand–object interaction sounds within SI, but not for either control category. Crucially, in the hand-sensitive voxels defined from an independent tactile localizer, decoding accuracies were significantly higher for hand–object interactions compared to pure tones in left SI. Our findings indicate that simply hearing sounds depicting familiar hand–object interactions elicit different patterns of activity in SI, despite the complete absence of tactile stimulation. These results highlight the rich contextual information that can be transmitted across sensory modalities even to primary sensory areas.
Antibiotic Indications and Appropriateness in the Pediatric Intensive Care Unit: A 10-Center Point Prevalence Study
Authors: Chiotos Kathleen , Blumenthal Jennifer , Boguniewicz Juri , Palazzi Debra L , Stalets Erika L , Rubens Jessica H , Tamma Pranita D , Cabler Stephanie S , Newland Jason , Crandall Hillary , Berkman Emily , Kavanagh Robert P , Stinson Hannah R , Gerber Jeffrey S 
Published: September 2022

Abstract

Background
Antibiotics are prescribed to most pediatric intensive care unit (PICU) patients, but data describing indications and appropriateness of antibiotic orders in this population are lacking.

Methods
We performed a multicenter point prevalence study that included children admitted to 10 geographically diverse PICUs over 4 study days in 2019. Antibiotic orders were reviewed for indication, and appropriateness was assessed using a standardized rubric.

Results
Of 1462 patients admitted to participating PICUs, 843 (58%) had at least 1 antibiotic order. A total of 1277 antibiotic orders were reviewed. Common indications were empiric therapy for suspected bacterial infections without sepsis or septic shock (260 orders, 21%), nonoperative prophylaxis (164 orders, 13%), empiric therapy for sepsis or septic shock (155 orders, 12%), community-acquired pneumonia (CAP; 118 orders, 9%), and post-operative prophylaxis (94 orders, 8%). Appropriateness was assessed for 985 orders for which an evidence-based rubric for appropriateness could be created. Of these, 331 (34%) were classified as inappropriate. Indications with the most orders classified as inappropriate were empiric therapy for suspected bacterial infection without sepsis or septic shock (78 orders, 24%), sepsis or septic shock (55 orders, 17%), CAP (51 orders, 15%), ventilator-associated infections (47 orders, 14%), and post-operative prophylaxis (44 orders, 14%). The proportion of antibiotics classified as inappropriate varied across institutions (range, 19%–43%).

Conclusions
Most PICU patients receive antibiotics. Based on our study, we estimate that one-third of antibiotic orders are inappropriate. Improved antibiotic stewardship and research focused on strategies to optimize antibiotic use in critically ill children are needed.
Liver Inflammation Is Common and Linked to Metabolic Derangements in Persons With Treated Human Immunodeficiency Virus (HIV)
Authors: Chew Kara W , Wu Kunling , Tassiopoulos Katherine , Palella Frank J , Naggie Susanna , Utay Netanya S , Overton Edgar T , Sulkowski Mark 
Published: September 2022

Abstract

Background
We sought to characterize in people with human immunodeficiency virus (PWH) the potential etiologies of elevated alanine aminotransferase (ALT) levels, which are common and often unexplained.

Methods
Participants from the longitudinal observational AIDS Clinical Trials Group HAILO cohort without a history of hepatitis C virus (HCV) or hepatitis B virus (HBV) infection nor reported heavy alcohol use were included. Clinical and demographic characteristics, including medication use, the hepatic steatosis index (HSI), and metabolic syndrome (MetS) were compared between participants with and without ALT elevation.

Results
Six hundred sixty-two participants were included; 444 (67%) had ≥1 and 229 (35%) ≥2 consecutive ALT elevations during a median of 4.0 years of follow-up. HSI and Hispanic or other (non-White or Black) race/ethnicity were consistently associated with higher odds of abnormal ALT (odds ratio [OR] 1.1 for HSI as a continuous variable, OR 1.9–2.8 for Hispanic/other race/ethnicity for ≥1 or ≥2 ALT elevations); older age and current smoking were associated with lower odds of abnormal ALT. Associations with metabolic disease, as well as with incident HBV and HCV infection, were strengthened by restricting outcomes to persistent and higher degrees of ALT elevation.

Conclusions
ALT elevation was common in this cohort of PWH and associated with metabolic disease and hepatic steatosis markers. Nonalcoholic fatty liver disease is likely a common cause of liver inflammation in PWH receiving suppressive antiretrovirals, deserving targeted diagnosis and intervention.
Challenges and Opportunities in Designing and Deploying Remote Health Monitoring Technology for Older Adults With Cancer
Authors: LeBaron Virginia 
Published: September 2022

AbstractRemote health monitoring (RHM) technologies (eg, wearables, smart phones, embedded sensors, and telehealth platforms) offer significant opportunities to improve health and wellness for older adults facing serious illness. This article highlights key challenges and opportunities for designing and deploying RHM systems in the context of caring for older adults with cancer, with an emphasis on the key role nurses can play in this work. Focal topics include user-centered design, interdisciplinary collaboration, addressing health inequities and disparities, privacy and data security, participant recruitment and burden, personalized and tailored care, rapid technological change, family caregiver perspectives, and naturalistic data collection. It is critical for nurses to be aware of both challenges and opportunities within each of these areas in order to develop RHM systems that are optimally beneficial for patients, family caregivers, clinicians, and organizations. By leveraging their unique knowledge of the illness experience from the patient, family, and health care provider perspective, nurses can make essential clinical and scientific contributions to advance the field of RHM.