bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engaging advanced practice nurses in evidence‐based practice: An e‐mentoring program
Authors: Hooge Nicolette , Allen Deborah Hutch , McKenzie Rebecca , Pandian Vinciya 
Published: February 2022

AbstractBackgroundMentoring is highly valued in the nursing profession and essential to building an evidence‐based practice (EBP) culture. However, many organizations have a limited number of EBP mentors, who have limited non‐clinical time to engage in mentoring.AimsThis project aimed to test whether an e‐mentoring approach to nursing inquiry could enhance EBP beliefs (EBPB), increase EBP Implementation (EBPI), and improve Organizational Culture and Readiness for System‐Wide Implementation of EBP (OCRSIEP).MethodsA pre‐experimental pilot intervention project was implemented utilizing a pretest‐posttest design with Advanced Practice Registered Nurses’ (APRNs) in clinical practice. The OCRSIEP, EBPB, and EBPI scales were used to measure organizational readiness for EBP implementation, individual beliefs regarding the value of EBP, and the extent to which nurses integrate scientific evidence into their clinical practice, respectively. The Wilcoxon‐Signed Rank test was used to analyze the difference between pretest and posttest scores of an EBP E‐mentoring program. A post‐hoc analysis was performed to calculate effect sizes.[Correction added on 13 May 2022, after first online publication: The Methods section was revised to add additional details.]ResultsEleven APRNs completed the pretest and posttest surveys. When comparing the pre‐and post‐intervention scores, the median EBPB scores increased from 61 (IQR: 56–69) to 70 (IQR: 64–73), median EBPI scores increased from 13 (IQR: 7–33) to 20 (IQR: 13–31), and median OCRSIEP scores increased from 88 (IQR: 73–97) to 99 (IQR: 90–113).Linking Evidence to ActionA 12‐week Nurse Inquiry E‐mentoring Program can leverage the small number of EBP mentors in an organization to improve EBPB. A program lasting longer in duration may also significantly improve EBPI and OCRSIEP scores. By utilizing technology and leveraging economies of scale, exponentially more nurses can be mentored to create and enhance an EBP culture.
Conflicts among protected native birds and valuable sport fishes: potential pelican predation effects
Authors: Budy Phaedra , Thiede Gary P. , Chapman Kevin , Howe Frank P. 
Published: February 2022

Reservoirs are examples of novel ecosystems that have developed into popular sport fisheries; these systems are also becoming seasonal refuges for migratory birds, including the piscivorous American white pelican ( Pelecanus erythrorhynchos). We (1) investigated the proportion of cutthroat trout ( Oncorhynchus clarkii utah) and other species consumed by pelicans, (2) compared whether pelicans have an adverse effect on cutthroat trout spawning movement, and (3) determined the importance of pelican predation relative to other sources of fish mortality in Strawberry Reservoir, Utah, USA. Pelican diet samples consisted of >85% Utah sucker ( Catostomus ardens), 6% Utah chub ( Gila atraria), and 3% cutthroat trout. Based on bioenergetics, we estimated that pelicans consumed 384–3020 individual cutthroat trout (0.17%–1.3% of population), in contrast to 14 166–27 196 nongame sucker and chub. Bird-related mortality rate ranged from 1% to 6% for stocked, PIT (passive integrated transponder)-tagged adult cutthroat trout and from 4% to 16% for subadult cutthroat trout. Based on these results, any management action taken to control pelican predation would need to be weighed against the benefits of nongame fish removal and the protected status of pelicans.
Probability Distribution and Determination of Blast Loading during Structural Blast Resistant Study
Authors: Yang Taochun , Luo Yaozhi , Hu Guangqing , Jiang Yi 
Published: February 2022

Explosion overpressure and its duration are important parameters describing blast loading. However, their values obtained using the currently available methods differ significantly. To address this problem, we simulated the overpressure reflection coefficient (i.e., the ratio of reflection overpressure to incident overpressure) and fitted the analytical expressions to the test data. We then collected a large amount of theoretical and experimental blast loading data from literature and studied the probability distribution of blast loading for different scaled distances. The results show that the probability density function of explosion overpressure obeys an exponential distribution when the scaled distance is between 0.1

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and 0.5

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. On the other hand, it obeys a normal distribution when the scaled distance is greater than 0.5

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. The coefficient of variation reaches the maximum value of 1 when the scaled distance is between 0.1

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and 0.5

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, while it is between 0.13 and 0.2 when the scaled distance is from 1.5

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to 6

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. The coefficient of variation of reflected overpressure is slightly bigger than that of incident overpressure. Nevertheless, the coefficient of variation of proportional duration (i.e., the ratio of actual duration to cubic root of charge mass) is generally smaller, between 0.408 and 1.017. It was also found that there is no clear probability distribution for the blast loading duration. Finally, formulas for the explosion overpressure and proportional duration were determined together with their 95% confidence level bounds.
Revision of the high-altitude genus Hyphinomos Uvarov, 1921 (Orthoptera: Tettigoniidae) with a redescription and new data on mating behavior and acoustic signals of H. svenhedini Ramme, 1950
Authors: ALI AHSAN , JAISWARA RANJANA , MONAAL  , KUMAR NEELIMA R , BHARTI UMESH , HELLER KLAUS-GERHARD 
Published: February 2022

High mountains are known for their unique habitats and extreme climatic conditions. Many inhabitants of this area are specialists and are known as hypsobionts. Among Ensifera, only selected species from different genera are true hypsobionts. Species in the genus Hyphinomos are one of them. Hyphinomos occurs only between 3800 and 5500 m a.s.l., and is known from two species, fasciata Uvarov, 1921 and svenhedini Ramme, 1950. Until recently they were both known only from their type localities situated in mountain ranges of the Himalayas. In this paper, we amend the description of H. svenhedini by adding new data on its distribution, habitat, structure of the male genitalia, stridulatory structures, acoustic signals (long-distance and courtship), and mating behavior. In addition, we have revised the description of Hyphinomos.
Notes on the genus Chrysodema from China (Coleoptera: Buprestidae: Chrysochroinae), with one new species and one new record
Authors: QI ZHI-HAO , AI HONG-MU , SONG HAI-TIAN 
Published: February 2022

The genus Chrysodema currently recorded from China contains 6 species/subspecies: C. (Chrysodema) aurostriata Saunders, 1866 from Yunnan, C. (C.) lewisii nakatai Frank & Sekerka, 2020, C. (C.) eximia berliozi Descarpentries, 1948, C. (Pseudochrysodema) dalmanni dalmanni (Mannerheim, 1837), C. (P.) dalmanni penghuensis Hattori & Ong, 2020 and C. (P.) yasumatsui Kurosawa, 1954 all from Taiwan. In this study, one new species, Chrysodema (Chrysodema) hainanensis sp. nov. from Hainan Island, China is described, illustrated, and the variation is given. The host plant Toona ciliata is new for the genus Chrysodema. The differences of the new species to its related species and subspecies are discussed and keyed. C. (C.) aurostriata from Yunnan probably belonged to C. (C.) vrabeci and still need verification. C. (C.) tonkinea Kerremans, 1909 was recorded from Guangxi (new country record). All Chrysodema species and subspecies recorded from China except C. (P.) dalmanni penghuensis and the unverified C. (C.) aurostriata were examined, and a key is given for identification.
Neglect in Childhood, Problem Behavior in Adulthood
Authors: Dubowitz Howard , Roesch Scott , Lewis Terri , Thompson Richard , English Diana , Kotch Jonathan B. 
Published: February 2022

Few studies have reported problem behaviors in adulthood related to the timing of child neglect. The objective was to examine the relationship between classes of child neglect and later behavior. The sample included 473 participants from the prospective Longitudinal Studies of Child Abuse and Neglect (LONGSCAN); their mean age was 23.8 years. They completed an online survey regarding behaviors and experiences in early adulthood. Neglect was assessed via Child Protective Services (CPS) and self-reports of neglect. Latent class analysis (LCA) identified three classes: Late Neglect, Chronic Neglect, and Limited Neglect. There were significant differences between Limited and Late Neglect regarding later intimate partner aggression and violence (IPAV) and psychological distress, and among all classes for criminal behavior. High-risk youth experiencing neglect beginning in mid-adolescence appear especially vulnerable to later criminal behavior, psychological distress, and IPAV. Those working with such youth can help ensure that their needs are adequately met, to prevent or mitigate problems in adulthood.
Childhood infections and autism spectrum disorders and/or intellectual disability: a register-based cohort study
Authors: Karlsson Håkan , Sjöqvist Hugo , Brynge Martin , Gardner Renee , Dalman Christina 
Published: February 2022

AbstractObjectiveTo explore the associations between childhood infections and subsequent diagnoses of autism spectrum disorder (ASD), intellectual disability (ID), and their co-occurrence.MethodsThe association between specialized care for any infection, defined by ICD-codes, and later ASD or ID was investigated in a register-based cohort of 556,732 individuals born 1987–2010, resident in Stockholm County, followed from birth to their 18th birthday or December 31, 2016. We considered as potential confounders children’s characteristics, family socioeconomic factors, obstetric complications, and parental histories of treatment for infection and psychiatric disorders in survival analyses with extended Cox regression models. Residual confounding by shared familial factors was addressed in sibling analyses using within-strata estimation in Cox regression models. Sensitivity analyses with the exclusion of congenital causes of ASD/ID and documented risk for infections were also performed.ResultsCrude estimates indicated that infections during childhood were associated with later ASD and ID with the largest risks observed for diagnoses involving ID. Inclusion of covariates, exclusion of congenital causes of ASD/ID from the population, and sibling comparisons highlighted the potential for confounding by both heritable and non-heritable factors, though risks remained in all adjusted models. In adjusted sibling comparisons, excluding congenital causes, infections were associated with later “ASD without ID” (HR 1.24, 95%CI 1.15–1.33), “ASD with ID” (1.57, 1.35–1.82), and “ID without ASD” (2.01, 1.76–2.28). Risks associated with infections varied by age at exposure and by age at diagnosis of ASD/ID.ConclusionsInfections during childhood may contribute to a later diagnosis of ID and ASD.
The research landscape of tuberous sclerosis complex–associated neuropsychiatric disorders (TAND)—a comprehensive scoping review
Authors: Vanclooster Stephanie , Bissell Stacey , van Eeghen Agnies M. , Chambers Nola , De Waele Liesbeth , Byars Anna W. , Capal Jamie K. , Cukier Sebastián , Davis Peter , Flinn Jennifer , Gardner-Lubbe Sugnet , Gipson Tanjala , Heunis Tosca-Marie , Hook Dena , Kingswood J. Christopher , Krueger Darcy A. , Kumm Aubrey J. , Sahin Mustafa , Schoeters Eva , Smith Catherine , Srivastava Shoba , Takei Megumi , Waltereit Robert , Jansen Anna C. , de Vries Petrus J. 
Published: February 2022

Abstract
Background
Tuberous sclerosis complex (TSC)–associated neuropsychiatric disorders (TAND) is an umbrella term for the behavioural, psychiatric, intellectual, academic, neuropsychological and psychosocial manifestations of TSC. Although TAND affects 90% of individuals with TSC during their lifetime, these manifestations are relatively under-assessed, under-treated and under-researched. We performed a comprehensive scoping review of all TAND research to date (a) to describe the existing TAND research landscape and (b) to identify knowledge gaps to guide future TAND research.

Methods
The study was conducted in accordance with stages outlined within the Arksey and O’Malley scoping review framework. Ten research questions relating to study characteristics, research design and research content of TAND levels and clusters were examined.

Results
Of the 2841 returned searches, 230 articles published between 1987 and 2020 were included (animal studies = 30, case studies = 47, cohort studies = 153), with more than half published since the term TAND was coined in 2012 (118/230; 51%). Cohort studies largely involved children and/or adolescents (63%) as opposed to older adults (16%). Studies were represented across 341 individual research sites from 45 countries, the majority from the USA (89/341; 26%) and the UK (50/341; 15%). Only 48 research sites (14%) were within low–middle income countries (LMICs). Animal studies and case studies were of relatively high/high quality, but cohort studies showed significant variability. Of the 153 cohort studies, only 16 (10%) included interventions. None of these were non-pharmacological, and only 13 employed remote methodologies (e.g. telephone interviews, online surveys). Of all TAND clusters, the autism spectrum disorder–like cluster was the most widely researched (138/230; 60%) and the scholastic cluster the least (53/200; 27%).

Conclusions
Despite the recent increase in TAND research, studies that represent participants across the lifespan, LMIC research sites and non-pharmacological interventions were identified as future priorities. The quality of cohort studies requires improvement, to which the use of standardised direct behavioural assessments may contribute. In human studies, the academic level in particular warrants further investigation. Remote technologies could help to address many of the TAND knowledge gaps identified.
Pharmacodynamic evaluation and safety assessment of treatment with antibodies to serum amyloid P component in patients with cardiac amyloidosis: an open-label Phase 2 study and an adjunctive immuno-PET imaging study
Authors: Wechalekar Ashutosh , Antoni Gunnar , Al Azzam Wasfi , Bergström Mats , Biswas Swethajit , Chen Chao , Cheriyan Joseph , Cleveland Matthew , Cookson Louise , Galette Paul , Janiczek Robert L. , Kwong Raymond Y. , Lukas Mary Ann , Millns Helen , Richards Duncan , Schneider Ian , Solomon Scott D. , Sörensen Jens , Storey James , Thompson Douglas , van Dongen Guus , Vugts Danielle J. , Wall Anders , Wikström Gerhard , Falk Rodney H. 
Published: February 2022

Abstract
Background
In a Phase I study treatment with the serum amyloid P component (SAP) depleter miridesap followed by monoclonal antibody to SAP (dezamizumab) showed removal of amyloid from liver, spleen and kidney in patients with systemic amyloidosis. We report results from a Phase 2 study and concurrent immuno-positron emission tomography (PET) study assessing efficacy, pharmacodynamics, pharmacokinetics, safety and cardiac uptake (of dezamizumab) following the same intervention in patients with cardiac amyloidosis.

Methods
Both were uncontrolled open-label studies. After SAP depletion with miridesap, patients received ≤ 6 monthly doses of dezamizumab in the Phase 2 trial (n = 7), ≤ 2 doses of non-radiolabelled dezamizumab plus [89Zr]Zr-dezamizumab (total mass dose of 80 mg at session 1 and 500 mg at session 2) in the immuno-PET study (n = 2). Primary endpoints of the Phase 2 study were changed from baseline to follow-up (at 8 weeks) in left ventricular mass (LVM) by cardiac magnetic resonance imaging and safety. Primary endpoint of the immuno-PET study was [89Zr]Zr-dezamizumab cardiac uptake assessed via PET.

Results
Dezamizumab produced no appreciable or consistent reduction in LVM nor improvement in cardiac function in the Phase 2 study. In the immuno-PET study, measurable cardiac uptake of [89Zr]Zr-dezamizumab, although seen in both patients, was moderate to low. Uptake was notably lower in the patient with higher LVM. Treatment-associated rash with cutaneous small-vessel vasculitis was observed in both studies. Abdominal large-vessel vasculitis after initial dezamizumab dosing (300 mg) occurred in the first patient with immunoglobulin light chain amyloidosis enrolled in the Phase 2 study. Symptom resolution was nearly complete within 24 h of intravenous methylprednisolone and dezamizumab discontinuation; abdominal computed tomography imaging showed vasculitis resolution by 8 weeks.

Conclusions
Unlike previous observations of visceral amyloid reduction, there was no appreciable evidence of amyloid removal in patients with cardiac amyloidosis in this Phase 2 trial, potentially related to limited cardiac uptake of dezamizumab as demonstrated in the immuno-PET study. The benefit-risk assessment for dezamizumab in cardiac amyloidosis was considered unfavourable after the incidence of large-vessel vasculitis and development for this indication was terminated.
Trial registration NCT03044353 (2 February 2017) and NCT03417830 (25 January 2018).
Cumulative incidence and predictors of acquired aortic stenosis in a large population of men followed for up to 43 years
Authors: Kontogeorgos Silvana , Thunström Erik , Lappas Georgios , Rosengren Annika , Fu Michael 
Published: February 2022

Abstract
Background
Acquired aortic stenosis (AS) increases with age and has high mortality without intervention. Factors predicting its development are unclear, although atherosclerotic factors are assumed to be involved. Our aim in this study is to estimate the lifetime cumulative incidence and predictors of AS in middle-aged men.

Methods
We included a random sample of men (n = 9998) born 1915–1925 in Gothenburg, Sweden. From them, 7,494 were examined and followed until a diagnosis of AS or death (maximum follow-up time 42.8 years). We identified AS diagnosis from the Swedish National Patient Registry and deaths from the Swedish Cause of Death Registry by using International Classification of Disease (ICD) diagnostic criteria. To study time-dependent relationships between AS and risk factors with death as the competing risk, we divided the cohort into three overlapping follow-up groups: 25–43, 30–43 and 35–43 years. We used age-adjusted Cox proportional hazards model to identify predictors of AS.

Results
The lifelong cumulative incidence of AS was 3.2%. At baseline, participants in the third group had a healthier lifestyle, lower body mass index (BMI), blood pressure, and serum cholesterol levels. Higher BMI, obesity, cholesterol, hypertension, atrial fibrillation, smoking and heredity for stroke were associated with AS. With BMI of 20–22.5 as a reference, hazard ratios of being diagnosed with AS for men with a baseline BMI of 25–27.5 kg/m2, 27.5–30 kg/m2 and > 30 kg/m2 were 1.99 (95% CI 1.12–3.55), 2.98 (95% CI 1.65–5.40) and 3.55 (95% CI 1.84–6.87), respectively.

Conclusions
The lifetime cumulative incidence of AS in middle-aged male population was 3.2%. Multiple atherosclerotic risk factors, particularly high BMI might be associated with a higher risk of developing AS.
Risk of aortic aneurysm and aortic dissection with the use of fluoroquinolones in Korea: a nested case–control study
Authors: Son Nayeong , Choi Eunmi , Chung Soo Youn , Han Soon Young , Kim Bonggi 
Published: February 2022

Abstract
Background
Recent studies have raised concern about the association of fluoroquinolones with an increased risk of aortic aneurysm and aortic dissection. We aimed to evaluate such risk in a Korean population.

Methods
We conducted a nested case–control study using data from the National Health Insurance Service collected from 2013 to 2017 in Korea. The study cohort included patients older than 40 years and excluded patients who had used fluoroquinolones or been diagnosed with aortic aneurysm, aortic dissection, or related diseases 1 year prior to the cohort entry date. We randomly matched four controls in the risk set with each case of aortic aneurysm and aortic dissection (same sex, age, and cohort entry date). We assessed the risk of aortic aneurysm and aortic dissection from fluoroquinolones and adjusted for potential confounders using a conditional logistic regression model.

Results
A total of 29,638 aortic aneurysm and aortic dissection patients were identified between 2014 and 2017. The use of fluoroquinolones within a year was associated with a 10% increased risk of aortic aneurysm and aortic dissection (adjusted odds ratio: 1.10, 95% CI 1.07–1.14, p < 0.05) compared with nonusers. The risk was higher in patients who had used fluoroquinolones within 60 days (adjusted odds ratio: 1.53, 95% CI 1.46–1.62, p < 0.05). The risk of aortic aneurysm and aortic dissection positively correlated with the cumulative dose and duration of fluoroquinolone therapy (p < 0.001).

Conclusions
Our study provides real-world evidence of the risk of aortic aneurysm and aortic dissection from fluoroquinolones in Korea. Patients and medical professionals should be aware that fluoroquinolones can increase the risk of aortic aneurysm and aortic dissection, which may be acerbated by high dosage and duration of use.
The systemic-immune-inflammation index predicts the recurrence of atrial fibrillation after cryomaze concomitant with mitral valve surgery
Authors: Luo Yu , Zhang Jian , Liu Tao , Yin Zongtao , Jin Yan , Han Jinsong , Guo Zhipeng , Wang Huishan 
Published: February 2022

Abstract
Background and aims
Inflammation plays a key role in the initiation and progression of atrial fibrillation (AF). The systemic inflammation indexes are easily evaluated and predict AF development. However, it’s role in prediction of recurrence of AF is unknown. We aim to explore the association between the systemic inflammation indexes and recurrence of AF in patients underwent cryoablation (CryoMaze) concomitant with mitral valve surgery.

Methods
We examined systemic inflammation indexes during perioperative period in 122 patients between 2015 and 2018. Systemic inflammation indexes were developed by systemic immune-inflammation index (SII), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocytes to monocytes ratio. Univariate and multivariate analyses were performed to examine the association of each markers with recurrence of AF.

Results
Of the 122 patients included in this study, 22 patients (18%) experienced AF recurrence after CryoMaze concomitant with mitral valve surgery. There is no significant difference between each systemic inflammation indexes before surgery and recurrence of AF. In univariate analysis, MLR after surgery 3 days, PLR, MPLR, NLR, SII after surgery 7 days were able to predict recurrence of AF. In multivariate analyses, SII ≥ 1696 independently predicted recurrence (OR, 3.719; 95% CI, 1.417–9.760). Interestingly, baseline SII showed no significant in prediction of recurrence. It was sharply elevated after surgery and dropped slowly. In patients of recurrence, SII after 7 days of surgery increased again.

Conclusions
The raised SII again was associated with an increased risk of the postoperative recurrence of AF and independently predicted the late recurrence of AF after CryoMaze concomitant with mitral valve surgery.