bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diabetes, heart damage, and angiotensin II. What is the relationship link between them? A minireview
Authors: Pedreanez Adriana , Mosquera Jesus , Munoz Nelson , Robalino Jorge , Tene Diego 
Published: February 2022

Abstract
Cardiovascular complications are the main cause of mortality and morbidity in the diabetic patients, in whom changes in myocardial structure and function have been described. Numerous molecular mechanisms have been proposed that could contribute to the development of a cardiac damage. In this regard, angiotensin II (Ang II), a proinflammatory peptide that constitutes the main effector of the renin-angiotensin system (RAS) has taken a relevant role. The aim of this review was to analyze the role of Ang II in the different biochemical pathways that could be involved in the development of cardiovascular damage during diabetes. We performed an exhaustive review in the main databases, using the following terms: angiotensin II, cardiovascular damage, renin angiotensin system, inflammation, and diabetes mellitus. Classically, the RAS has been defined as a complex system of enzymes, receptors, and peptides that help control the blood pressure and the fluid homeostasis. However, in recent years, this concept has undergone substantial changes. Although this system has been known for decades, recent discoveries in cellular and molecular biology, as well as cardiovascular physiology, have introduced a better understanding of its function and relationship to the development of the diabetic cardiomyopathy.
Omega-3 supplementation in the treatment of polycystic ovary syndrome (PCOS) – a review of clinical trials and cohort
Authors: Melo Vitoria , Silva Thomas , Silva Thaissa , Freitas Juliana , Sacramento Joselita , Vazquez Mirian , Araujo Edilene 
Published: February 2022

Abstract
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women associated with cardiovascular disease and obesity. The possible benefits of omega-3 supplementation in this syndrome have been discussed much. This study is aimed to verify, based on the scientific data published, if there are any benefits in the omega-3 supplementation in the treatment of PCOS and to indicate its possible dosages for the treatment of polycystic ovary. The work consists of a systematic review of clinical trials and cohort of the MEDLINE/PubMed database from 2009 to October 2019. All studies that analyzed the omega-3 supplementation in women with PCOS were included. Cross-sectional studies, review articles, systematic reviews, meta-analysis, duplicates, studies in animals or cell culture, studies with omega-3 supplementation via food or associated with other supplementations were not included, except those involving vitamin E. In total, 21 articles were selected. Despite the heterogeneity of the studies selected, indirect benefits were observed mainly regarding the glycemic profile, such as insulin resistance reduction, lipid profile modulation (i.e. decrease in total cholesterol, triglycerides, and elevation of high-density lipoprotein), and the regulation of the androgenic profile. As for the anthropometric profile, the studies were scarce and most of them had no significant meaning. Regarding the antioxidant profile and inflammatory biomarkers, the findings differ among studies, but promising results were observed with different doses over 12 weeks of use, such as C-reactive protein (CRP) reduction. Thus, omega-3 fatty acids promote indirect benefits in the treating of women with PCOS. However, to reveal well-defined standards for dosage and supplementation time, further studies are needed.
Legislative Conditions for Trade in Biological Material of Farm Animals from a Health Perspective
Authors: Lipińska Izabela 
Published: February 2022

Abstract
This article addresses issues related to the movement of livestock biological material that is used for reproduction. Its movement may be accompanied by the spread of pathogens. To avoid this, specific instruments have been adopted at EU and national level. The aim of this paper is to evaluate the legal standards adopted in this field, which shape the circulation of biological material in the aspect of livestock health safety. In conclusion, it was stated that the normative solutions established at the EU level lead to the unification and harmonization of conditions concerning trade in biological material of livestock, and thus meet the objectives set out in it. Nevertheless, national regulations should be modified in this respect and supported by executive acts allowing for full implementation of the EU solutions.
Cross–Border Public Procurement in the European Union
Authors: Malatinec Tomáš 
Published: February 2022

Abstract
Joint cross–border public procurement is a public procurement procedure in which a contract is awarded jointly by contracting authorities from two or more Member States. Such an approach con-tributes to the fulfilling potential offered by the EU Single Market. The aim of the paper is to con-tribute to the analytical results focused on the evaluation of joint cross–border procurement. The results are processed on the basis of data selected from TED. The results show that this approach in public procurement is not commonly used by contracting authorities. The use of this approach is dominated by the supply of services and the use of open procedure as a tendering procedure.
Legal Tools in International Environmental Law
Authors: Szira Zoltán , Alghamdi Hani , Varga Erika , Bárdos Kinga 
Published: February 2022

Abstract
Environmental law concepts are expressed in conventions, international binding laws, state practice and soft law commitments. They may be applicable to all foreign community members. These are widely recognized and even approved in the practice of the state.
A special feature of international environmental law is that many environmental issues are governed by non–binding soft–law instruments that allow faster responses to international environmental issues. Governments tend to resist legally binding treaty regulation for different reasons but are much more likely to adopt a written action plan or resolution, at least voicing a political will to address an issue. The numerous constitutional standards of several countries must be followed when negotiating international agreements: for example, the way the national parliament must approve and enforce a treaty. The paper investigates the regulation system of international environmental law.
Study of Glioblastomas According to Clinicopathological Parameters
Authors: Sipos Tamás Csaba , Kövecsi Attila , Gurzu Simona , Dénes Lóránd , Szántó Annamária , Ráduly Gergő , Pap Zsuzsanna 
Published: February 2022

Abstract

Background: Glioblastomas are the most common tumors of the central nervous system. The incidence of brain tumors is higher in developed countries and is constantly increasing.

Aim of the study: The purpose of this study was to analyze the clinicopathological data of patients diagnosed with glioblastomas from a selected case series.

Material and methods: This retrospective, single-center study was conducted on glioblastoma cases diagnosed between 2014 and 2018 at the Department of Pathology of the County Emergency Clinical Hospital of Târgu Mureș, Romania. The information was centralized from histopathology reports and focused on the location of glioblastomas and demographic parameters (gender and age of patients).

Results: In the studied period, there were 154 patients diagnosed with glioblastoma, of which 50.65% were men. The most affected age group was 61–70 years (31.17% of cases). In most cases (49.35%), the glioblastoma was located in the left cerebral hemisphere, and the most affected lobes were the frontal (29.87%), temporal (26.62%), and parietal (14.94%). We could not find a statistically significant association between the distribution of cases by years, gender, and location of the tumor.

Conclusions: Glioblastoma is a tumor that involves the left cerebral hemisphere most often and affects both genders over the age of sixty.
Are Mandatory Institutional Emails for Manuscript Submission an Unfair and Discriminatory Policy?
Authors: Teixeira da Silva Jaime A. 
Published: February 2022

Abstract
With increasing cases of fraud in submission, peer review, and publication processes, some by authors with fake identities and who use concocted emails, including the use of web-based emails, editors and publishers are looking for ways to try and stem the tide of fraud. In some journals, editors and publishers mistakenly believe that this might be possible by implementing a policy that mandates submitting authors to have an institutional email. However, this may be discriminatory at various levels, the most obvious of which is unfairness, i.e., no right to “entry” to a journal based exclusively on the type of email used, even more so when the submitting author is not fake. Such policies might, very ironically, even violate stated journal or publisher policies on discrimination and inclusivity. Editors and publishers that employ such tactics, as a way to attempt to reduce fraudulent submissions, need to rethink this potentially discriminatory strategy. In a publishing world that is becoming increasingly litigious, it would not be surprising if legal action would one day be taken against a journal or publisher by a valid author using a web-based email such as @gmail.com, @yahoo.com, or @163.com, but who may have been unfairly barred entry to that journal based on such a policy. Two real case examples are provided, Tumor Biology, a struggling journal published by IOS Press, and Journal of Business Ethics, a journal published by Springer Nature.
A Link Between Platelet-to-Lymphocyte Ratio and Helicobacter pylori Infection
Authors: Frandeș Sergiu Ioan , Chibulcutean Oana , Bățagă Simona 
Published: February 2022

Abstract

Background: Gastritis is a progressive disease that evolves from a non-atrophic to an atrophic state and progresses through intestinal metaplasia, even leading to gastric cancer. Gastritis is defined by an inflammatory process of the mucosal lining of the stomach.

Aim: We aimed to identify any association between Helicobacter pylori (H. pylori)-positive gastritis and simple inflammatory markers derived from a complete blood count such as the platelet-to-lymphocyte ratio (PLR).

Material and Methods: We performed a retrospective case-control study in which we included patients who underwent an upper digestive endoscopy with biopsy between January 2019 and December 2020 and were diagnosed with gastritis. H. pylori status was determined from the histopathological examination, and complete blood count was performed from venous blood samples. The final study group included 125 patients with H. pylori-positive chronic gastritis, and the control group was made up by 207 patients without H. pylori infection.

Results: We found a higher value of the PLR in H. pylori-positive patients than in the control group, but the difference was not significant statistically.

Conclusions: PLR levels could be a predictor of inflammation in H. pylori infection, but an extensive study is needed to confirm this theory.
Teaching literature at Slovak secondary schools (Text and context in literary education)
Authors: Vitézová Eva 
Published: February 2022

Abstract
The teaching of literature (and at the same time the teaching of the history of national literature) together with education in the field of the mother tongue has always been one of the key areas of education in the Slovak school system, therefore they have always received due and even special attention. Literary education (teaching literature) is a specific school process of literary communication and metacommunication, which can be interpreted in two ways in secondary school conditions: the first represents literary education as a traditional and stable part of the subject Slovak language and literature. Its goal is to prepare the pupil for the maturita exam. The second view presents literary education as a way to search for the meaning of human life through a functional chain of reception and interpretation of artistic texts. A fundamental problem of current education in the field of literature is the transfer of information from the latest scientific research into school practice. Another long-term and permanent problem of teaching literature at Slovak grammar schools and secondary schools is that literary education practice overestimates the informative component of the curriculum focused on memory acquisition. The paper introduces and discusses the number of theoretical and practical problems which arise in connection with the above-mentioned problems, as well as with teaching literary analysis and organizing the complex of tasks related to the meaningful reading of literary texts.
Europe as an extended Greece: Travelogues by Karl Kerényi and Gábor Devecseri
Authors: Polgár Anikó 
Published: February 2022

Abstract
This study is dealing with the travel notes and diaries in Hungarian and German from the 1950s and 1960s. The two examined authors are Karl (Károly) Kerényi (1897–1973) and Gábor Devecseri (1917–1971). Kerényi’s travel notes and diaries reveal the thoughts of a very wide-ranging scholar. Devecseri’s volume Crickets of Epidaurus, Sing (Epidauroszi tücskök, szóljatok) is actually a collection, condensed into the history of four trips: three to Greece and one to Italy. The present study examines the characteristics of these two perspectives, namely, the Western vs. the Eastern, the classic scholar’s vs. the scholarly poet’s using the contexts of travelogues and cultural memory as a point of departure. While for Kerényi, travel is a natural way of life, Devecseri travels and uses his idea based on his reading experiences as starting points. In the texts of both authors, we are confronted with both the archival and the current way of life of cultural memory.
Between the urge to know and the need to deny: trauma and embodied memories in Margaret Atwood’s Cat’s Eye (1988)
Authors: Lecheheb Ikram 
Published: February 2022

Abstract
The study intends to explore and analyze the role of corporeality in expressing earlier repressed traumatic events as manifested in Margaret Atwood’s Cat’s Eye (1988). It shows that the protagonist, Elaine Risley, is imprisoned within the prison of her traumatic past memories that still live involuntarily in her present, shaping her language and behavior. It equally reveals that the connection between the protagonist’s body and her conscious self is damaged due to overwhelming effects of her trauma; triggering her body to unconsciously project those traumatic memories. The study specifically examines how Atwood’s protagonist’s trauma returns through the cracks of her consciousness in a form of auditory and verbal hallucinations and dissociation from herself. In order to probe the connection between soma and trauma in Atwood’s novel, the study leans on a distillation of psychological theorizations; particularly Sigmund Freud’s emphasis on the somatic expression of trauma. Through a textual analysis of Atwood’s novel, the study highlights that trauma is responsible for the protagonist’s anxiety, fear and loss of language, seeking to examine how Atwood’s protagonist strives to heal from her earlier traumatic memories through different mediums including art.
Understanding gender bias toward physicians using online doctor reviews
Authors: Gupta Sonam , Jordan Kayla 
Published: February 2022

Abstract
Gender bias continues to be an ongoing issue in the field of medicine. While bias may come in many forms, patients’ biases and perceptions have been understudied and may impact adherence to treatment, leading to unequal outcomes. Online reviews for doctors are a naturalistic way to study gender bias. In this study, we leveraged the LIWC psychological linguistic analysis tool to analyze the language styles of ZocDoc and RateMDs reviews and understand the potential role of gender in patients’ perceptions of their doctors. Mean differences were calculated using bootstrapped hierarchical linear modeling. We found that reviews for female physicians are generally more informal and emotional than those for male physicians. While our study was exploratory, the results suggest that both patients and physicians need to increase their awareness of how their biases may be affecting how they give and receive vital health information.
Education for Advancing the Implementation of the Green Deal Goals for Bioeconomy
Authors: Kalnbalkite Antra , Pubule Jelena , Blumberga Dagnija 
Published: February 2022

Abstract
Evolving complex concepts, such as bioeconomy, in the most effective way, can be applied through the education of students and professionals. In recent years changes in the education system can be observed with the development of knowledge-based learning. Competence-based learning will also be used more and more in higher education. Higher education plays a crucial role in achieving the goals of the Green Deal and the bioeconomy. The main emphasis is on creating new and innovative technologies and methods to achieve these goals. A new master’s study program, ‘Environmental Engineering’, has been established at the Institute of Energy Systems and Environment of Riga Technical University. One of the study directions is ‘Bioeconomy’. Considering the developed direction ‘Bioeconomy’, the importance of this sector is visible. Attention should also be paid to the goals of the Green Deal. This study summarised research on education, bioeconomy and Green Deal topics and analysed the interrelationships between these studies using the VOSviewer tool. During the analysis, it is possible to conclude the main keywords that characterise these studies. The obtained keywords should indicate the development trends of future research, which is in line with education, the ‘Green Deal’, and bioeconomy.
Modeling of Mobile and Fixed Broadband Subscriptions of Countries with Fractional Calculus
Authors: Tuğrul Nisa Özge Önal , Başer Cennet , Ergün Esra , Karaçuha Kamil , Tabatadze Vasil , Eker Sebahattin , Karaçuha Ertuğrul , Şimşek Kevser 
Published: February 2022

Abstract
Today, operators have become the resource of telecommunications data. Therefore, knowledge about subscriptions is easily available for most countries. In recent years, high-speed mobile internet access subscriptions are also increasing rapidly. There are two important subscriptions reviewed by The International Telecommunication Union (ITU): mobile broadband (MBB) subscriptions and Fixed broadband (FBB) subscriptions. In this study, we proposed an original mathematical model employing the fractional analysis theory and evaluate its validity by modeling the mobile broadband and fixed broadband subscriptions of six countries including France, Italy, Turkey, Germany, Spain, and the U.K. Later, we compared the Fractional Model we developed with the Polynomial Model. The results show that the Fractional Model is superior to the conventional Polynomial Model in modeling broadband subscriptions. For all selected countries, our proposed Fractional approach outperforms conventional polynomial regression. For all investigation categories, on average, the fractional approach works better by at least 10% and at most 30%.
Crash Distribution Dataset: Development and Validation for the Undivided Rural Roads in Oromia, Ethiopia
Authors: Tola Alamirew Mulugeta , Demissie Tamene Adugna , Saathoff Fokke , Gebissa Alemayehu 
Published: February 2022

Abstract
Predicting the number of crashes that may occur as a result of specific highway features is critical in evaluating different treatment or design alternatives. Since different highway geometric characteristics can influence crash distribution datasets, Highway Safety Manual’s (HSM’s) predictive method encourages users to predict crashes based on their severity and collision type proportions. This study used crash data from rural two-way two-lane road segments in the Oromia region over seven years to develop Oromia’s fixed crash distribution dataset on Interactive Highway Safety Design Model (IHSDM) software. The crash distribution dataset has two parts; the crash severity proportions and the collision type percentages. The developed Oromia’s fixed crash distribution dataset was compared and validated against the default HSM crash configuration. As a result, the Crash Prediction Model (CPM) evaluation results confirmed that the developed crash severity proportion (the first part of the crash distribution dataset) estimates are more accurate and closer to the observed values. Furthermore, the findings show that crashes in the Oromia region are severer than in the states where the HSM crash configuration was developed. According to the second part of the crash distribution dataset evaluation (collision type percentage), the developed fixed crash distribution dataset outperforms the default HSM configuration in most collision type proportions, but not in all. For instance, from the ten collision type proportions developed, Right-Angle and sides-wipe collision proportions are predicted more precisely by the default HSM configuration. This points to the need for developing collision type proportion (the second part of the crash distribution dataset) as a function rather than a fixed configuration for a better result, based on the availability of complete crash data (i.e. crash location). In general, the study revealed that in order to exploit the full potential of HSM’s predictive approach, researchers must develop a jurisdiction crash distribution dataset using local crash data. The methodology demonstrated in this study to develop the jurisdiction’s crash distribution dataset has been validated as true thus, safety practitioners are encouraged to adopt it.
A Kalman Filter Based Hybrid Routing Protocol for Efficient Vehicle Connectivity and Traffic Management
Authors: Punia Divya , Kumar Rajender 
Published: February 2022

Abstract
The geographic routing protocols in Vehicular Ad Hoc Networks (VANETs) are contemplated as most efficacious protocols. Though, such types of protocols communicate a huge quantity of data that influence the network connectivity negatively. Also, out of bound issue is the second major disadvantage of geographic routing protocols. To provide a solution to these impediments, a novel K-PGRP (Kalman filter-Predictive Geographic Routing Protocol) routing protocol is proposed in this paper. K-PGRP is an improvement to PGRP (Predictive Geographic Routing Protocol) routing protocol and wields Kalman filter as a prediction module in PGRP routing protocol in order to anticipate the neighbor location and to select the propitious neighbor for advancing packets in both urban and highway framework which leads to efficient connectivity in the network and improves road safety. K-PGRP is then compared with PGRP, GPSR (Greedy Perimeter Stateless Routing) and GPCR (Greedy Perimeter Coordinator Routing) routing protocols in terms of throughput and packet delivery ratio metrics and outperformed all the simulation cases. The simulations were performed on MATLAB R2018a along with traffic simulator SUMO.