bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coconut endocarp shell ash (CESA): a non-conventional catalyst for green synthesis of 2- amino-4H-benzochromenes
Authors: Patil Sandip P. , Shinde Sachinkumar K. , Patil Suresh S. 
Published: August 2022

Abstract
In the present research, the coconut endocarp shell as a natural waste was converted into a valuable non-conventional catalyst by simple thermal treatment, namely coconut endocarp shell ash (CESA). The prepared CESA was characterized using several analytical techniques, including TGA, FT-IR, XRD, BET, SEM, and EDX. The catalytic property of the CESA was examined in the synthesis of pharmaceutically active 2-amino-4H-benzochromene derivatives via one-pot three component condensation of aldehydes, malononitrile, and α or β-naphthol in ethanol at room temperature. The most promising aspects of the presented approach are the high catalytic efficiency, short reaction time, excellent yield of products, operational simplicity, waste to wealth, and optimization with the design of experiment. Moreover, the CESA catalyst was recycled five times without any apparent loss of its catalytic activity.
The Integrated Fast Short-Circuit Protection Technique with Soft Turn-off for SiC MOSFET
Authors: Cao Jianwen , Zhou Zekun , Shi Yue , Zhang Bo 
Published: August 2022

Abstract
In this paper, the integrated fast short-circuit protection technique with soft turn-off is proposed for SiC (silicon carbide) MOSFET. Two short-circuit faults, HSF (hard switching fault) and FOF (flashover fault), can be judged by detecting EMI (electromagnetic interference) noises of SiC MOSFET. When there are short-circuit faults for SiC MOSFET, the soft turn-off is initiated to reduce EMI noises and protect SiC MOSFET. The proposed fast short-circuit protection technique is realized on the chip and is verified in a 0.18µm BCD process. Simulation results show that the proposed short-circuit protection has a fast response speed and then SiC MOSFET is turned off slowly when there are HSF and FOF. Therefore, the proposed fast short-circuit protection technique can be well applied for SiC MOSFETs, making SiC MOSFETs safely used in HV (high-voltage) and high current applications.
The Prognostic Significance of Further Axillary Dissection for Sentinel Lymph Node Micrometastases in Female Breast Cancer: A Competing Risk Analysis using the SEER Database
Authors: Zhou Yudong , Pu Shengyu , Jiang Siyuan , Li Danni , Li Shouyu , Liu Yang , Ren Yu , Hao Na 
Published: August 2022

Abstract
On the basis of the Surveillance, Epidemiology, and End Results (SEER) database, the aim of this study is to identify whether complete axillary lymph node dissection (ALND) is actually required and has an impact on breast cancer-specific survival (BCSS) and overall survival (OS) in breast cancer patients with micrometastases. We identified 13,848 women whose nodal status was micrometastases (pTxN1miM0) were classified into two groups: the sentinel lymph node biopsy (SLNB) only group and SLNB with complete ALND group. After the PSM, we found that the SLNB with complete ALND showed no significant difference in OS (HR = 1.04, 95% CI: 0.84–1.28, P = 0.73) or BCSS (HR = 1.03, 95% CI: 0.79–1.35, P = 0.82) compared to the SLNB only group. There was no statistically significant difference in the cumulative incidence of BCSD (Grey’s test, P = 0.819) or OCSD (Grey’s test, P = 0.788) for between the two groups either. Our results suggest that in early breast cancer patients with micrometastasis, complete ALND does not seem to be required and that SLNB suffices to control locoregional and distant disease, with no significant adverse effects on survival compared to complete ALND.
M-Health App for Tracking COVID-19 Infected People: A Case Study of Developing Countries
Authors: Alaiad Ahmad , Alzoubi Omar , Alyaseen Safa’a , Shatnawi Farah , Rawashdeh Saif 
Published: August 2022

Abstract
The impact of the COVID-19 pandemic has led to the use of M-Health apps for tracking COVID-19 infected people.So, the aim of this study was to develop a model that explains the adoption of M-Health apps for tracking COVID-19 infected people in developing countries. We tested the model based on data collected using an online survey with 283 participants. For data analysis , the partial least squares technique was used. The results revealed that the intention to use the Aman application was positively influenced by performance expectancy, social influence, Aman application quality, perceived self-efficacy, facilitating conditions, and perceived credibility. Moreover, it was negatively influenced by the perceived financial cost and the effort expectancy. M-Health apps are found as an approach to fighting COVID-19. Therefore, it is imperative to address the reasons that prevent the use of these apps. The implications of this are discussed.
MMPD-Net: An Aircraft Deformation Prediction Network Based on Multimodal Fusion
Authors: Kong Zhihao , Mao JianHua , Wang Jun , Lu Xiaofeng 
Published: August 2022

Abstract
In the assembly process of aircraft manufacturing, the aircraft structural is flexible, it is easy to deform under the influence of material factors and working condition factors. Therefore, it is necessary to propose a deformation prediction model to timely find deformation problems. In recent years, with the development of artificial intelligence technology, deep neural network has been widely used in intelligent manufacturing. This paper combines deep neural network with aircraft deformation prediction, and proposes an aircraft deformation prediction network that based on multimodal fusion (MMPD-Net). We consider both the aircraft structure data and the working condition data on aircraft deformation prediction. MMPD-Net extracts the features of aircraft structure mode and working condition mode respectively. We propose a multimodal fusion network to fuse features, which include the algorithm of average pooling and Bayesian decision. Compared with the mainstream point cloud classification network, MMPD-Net achieves higher classification accuracy on aircraft deformation dataset.
Interface and domain dynamics in ecological models
Authors: Hunt Parker , Jayaprakash Ciriyam 
Published: August 2022

Abstract
Ecosystems are known to undergo large-scale changes in their states termed regime shifts. These arise in models with alternative stable states when small changes in parameters lead to abrupt shifts. We study two spatially extended models with noise to elucidate the spatio-temporal behaviors that determine the relative stability of coexisting stable states. Motivated by results of equilibrium and non-equilibrium statistical mechanical models we study the dynamics of interfaces between states and of domains. We evaluate the velocity of the interface as a function of parameters such as rainfall in the interval in which bistability occurs. Domains of the stable state in an unstable background grow or shrink if their size is larger or smaller than a critical radius respectively. We have determined the critical radius that depends on curvature effects by numerical simulations. Thus, by studying a spatially explicit model, going beyond mean-field theory, we argue that regime shifts can occur before the deterministic (mean-field) bifurcation point depending on domain dynamics. Qualitative features are common to models with and without associated potentials. We study the effect of anomalous precipitation patterns with large deficits for a few years in a model with seasonal rainfall. We find a drastic decline of the vegetation followed by either collapse or recovery when the precipitation returns to normal. We find that domain dynamics and spatially averaged indicators such as variance can, at best, indicate relative resilience of states to large perturbations.
Development and Validation of Virtual Reality Combined with Shoulder Wheel Device for Active Rehabilitation Training
Authors: Hosaini Mohammad Reza , Sharini Hamid , Khabiri Hamid , Dehlaghi Vahab , Safarpoor Ali 
Published: August 2022

Abstract
Objective: To develop and validate the rehabilitation system based on virtual reality to increase patients' time of active rehabilitation during exercises.Methods: Thirty stroke patients admitted to rehabilitation clinics, who met the inclusion criteria, were selected after the initial evaluation performed by a physiotherapist. All patients were randomly divided into two groups. The first group was treated with common shoulder wheel therapy combined with virtual reality, and the control group was treated only with shoulder wheel therapy. Both groups received routine shoulder rehabilitation exercises for four weeks. Clinical assessments (action research arm test and Fugl-Meyer assessment) and functional testing (torque) were performed three times in a 15-day interval, and also a reaction rate-test for one time, at the end of rehabilitation.Results: Results showed that parameters of reaction rate and functional torque tests, clinical evaluations of action research arm test, and Fugl-Meyer assessment increased in both virtual reality and control groups during the treatment. Torque and reaction rate, as well as the Fugl-Meyer assessment functional test were significantly (p <0.05) higher in the intervention group than the control group. Although this difference indicated the relative superiority of virtual reality-based rehabilitation, there was no significant difference in action research arm test assessments (p >0.05).Dissuasion and Conclusion: A rehabilitation system based on virtual reality was designed and developed for stroke patients' shoulders and was evaluated clinically. Results indicate the influential role of virtual reality in improving shoulder functions and increasing active rehabilitation time in stroke patients.
Mechanisms behind large-scale inconsistencies between regional and global climate model-based projections over Europe
Authors: Taranu Ioan Sabin , Somot Samuel , Alias Antoinette , Boé Julien , Delire Christine 
Published: August 2022

Abstract
Important discrepancies in the large-scale summer climate change projections were recently detected between the global and regional climate models (RCM/GCM) in the EURO-CORDEX ensemble for several variables including surface temperature, total precipitation, and surface solar radiation. In this study, we use a new experimental framework inspired by the Big-Brother-Little-Brother protocol to explore the mechanisms responsible for generating large-scale discrepancies in future projections between GCM/RCM pairs over Europe in summer. Starting from past and future simulations with a perfect GCM/RCM pair (same resolution, same physics, same forcings), we then disentangle the role of potential sources of GCM/RCM inconsistency by carrying out targeted sensitivity studies. We show that by following such a perfect approach, it is possible to obtain a GCM/RCM pair without statistically significant inconsistencies in projected climate change. Such discrepancies are mainly generated by differences in aerosols representation and atmospheric physics. The role of plant physiology is limited and unlikely to be the dominant factor in the detected discrepancies. Finally, it is unlikely that the discrepancies in the EURO-CORDEX ensemble projections are a result of the upscaled added value, as we show that the effect of increased resolution is not strong enough and mostly limited to areas with complex topography. These findings raise important questions about the current practices in regional climate modelling. In the short term, implementing RCM external forcings consistent with the driving GCM can significantly improve the situation at low cost. In the long term, adopting a seamless strategy in developing the GCM/RCM models should be questioned.
Determination of the length of water function transition zones of braided rivers
Authors: YUAN Yu-liang , CHAO Li-qiang , REN Shuang , LI Ran , FENG Jing-jie , LIANG Si-zhen 
Published: August 2022

Abstract
Water environment function zones are designated for water environment management, among which transition zones are set to connect between different zones that implement different water quality standards. The method by which we effectively set the length of each transition zone is crucial for most rivers, particularly for complex topographic conditions, such as braided rivers. In this study, using the water transition zone of the Lhasa River, a depth-averaged planar two-dimensional hydrodynamic water quality model was established to simulate hydrodynamic conditions and pollutant transportation under different discharge rates. The length of the transition zone was then analyzed. Our results showed the river braid index changed with different discharge rates. When discharge increased from 41.8 to 273 m3/s, the exposed beach area decreased by approximately 36% and the braid index decreased by approximately 20%, from 3.63 to 2.90, resulting in the length of the transition zone to increase by 109% (from 11 to 23 km). Further analysis showed that the length of transition zone increases exponentially with the increase in flow and decreases logarithmically with the increase in braid index.
Human Alpha 1 Antitrypsin Suppresses NF-ĸB Activity and Extends Lifespan in Adult Drosophila
Authors: Yuan Ye , Belkum Max , O’Brien Alana , Garcia Alain , Troncoso Karla , Elshikha Ahmed , Zhou Lei , Song Sihong 
Published: August 2022

Abstract
Human alpha 1 antitrypsin (hAAT) is a multifunctional protein, which has been shown to have anti-inflammatory and cellular protective properties. While previous studies demonstrated the antiaging potential of hAAT, the mechanism(s) underlying the antiaging effect remain elusive. In this study, we performed a detailed analysis of transcriptomic data, which indicated that NF-ĸB-targeted genes and NF-ĸB-regulated-pathways were selectively inhibited by hAAT treatment. We further showed that the first detectable impact of hAAT treatment was the inhibition of the nuclear activity of NF-ĸB. Subsequently, hAAT treatment suppressed the mRNA levels of NF-ĸB targeted genes, as well as NF-ĸB itself (P65 and P50) in human senescent cells. Using Drosophila models, we further examined the impact of hAAT on locomotor activity and endurance. Finally, using an adult-specific promotor, we demonstrated that overexpression of hAAT in late stage of life significantly extended the lifespan of transgenic flies. These results extended the current understandings of the anti-inflammation function of hAAT.
Venetoclax plus “2 + 5” modified intensive chemotherapy with daunorubicin and cytarabine in fit elderly patients with untreated de novo acute myeloid leukemia: a single-center retrospective analysis
Authors: Wang Huafeng , Yao Yiyi , Mao Liping , Lou Yinjun , Ren Yianlin , Ye Xingnong , Yang Min , Ma Liya , Zhang Yi , Zhou Yile , Huang Xin , Wang Yungui , Xu Huan , Tong Hongyan , Zhu Hong-Hu , Jin Jie 
Published: August 2022

Abstract
Background
Therapeutic options remain limited for elderly acute myeloid leukemia (AML) considering the poor tolerance to intensive chemotherapy. Venetoclax in combination with modified intensive chemotherapy has been shown achieved significantly improved efficacy in elderly AML patients.
Methods
We conducted a retrospective study to evaluate the efficacy and safety of venetoclax plus daunorubicin and cytarabine induction chemotherapy (daunorubicin 60mg/m2 days 1–2, intravenously, cytarabine 100mg/m2 days 1–5, intravenously, and venetoclax 100mg day 3, 200mg day 4, 400mg days 5–10, orally, modified DAV regimen) in untreated fit de novo elderly AML.
Results
Twelve elderly patients who received a modified DAV regimen at our institution were enrolled from March 2021 to June 2022. Eleven of twelve (91.6%) patients achieved complete remission (CR), including 10 patients who achieved CR after one induction cycle and one patient who achieved CR after receiving a second repeated induction cycle. One patient with no response withdrew after one cycle of induction. All patients achieved measurable residual disease negativity detected by muti-parameter flow cytometry in responders. The median follow-up was 108 days. The median event-free survival (EFS) and overall survival (OS) were 398 days and not achieved separately, with an estimated 1-year EFS and OS rate of 75.0% and 100%, respectively. The most severe adverse events during induction therapy included 12 neutropenia (100%), 12 thrombocytopenia (100%), 12 anemia (100%), 5 febrile neutropenia (41.7%) and 4 pneumonia (33.3%). Myelosuppression recovered rapidly, without treatment-related deaths.
Conclusions
Our study showed the encouraging efficacy and good tolerability of the modified DAV regimen in untreated fit elderly AML patients.
Successful Retrieval of a Kinked Thermal Filament of a Swan-Ganz Catheter: a Case Report
Authors: Xie Yongguo , Du Xueke , Ming Shaopeng , Chen Lini , Ma Xiangfei , Qin Ke 
Published: August 2022

Abstract
Swan-Ganz pulmonary artery catheters enable continuous assessment of cardiac blood flow, left heart pressures, and oxygen delivery and consumption, with an uninterrupted view of cardiac function to facilitate proactive decisions in the most complex patients. However, complications of Swan-Ganz catheters have been continuously reported in clinical practice. Therefore, it is imperative to focus on prevention and treatment of Swan-Ganz catheter complications. This case presents successful management of an unusual complication, retrieval of a kinked thermal filament of a Swan-Ganz catheter in a 32-year-old male patient following liver transplantation. To our knowledge, this is the first reported case of a kinked thermal filament of a Swan-Ganz catheter. When the Swan-Ganz catheter was found to be difficult to withdraw, CT revealed that the Swan-Ganz catheter was kinked at the level of clavicle. Under X-ray guidance, the central venous catheter was first removed, followed by removal of the percutaneous introducer sheath, and finally the Swan-Ganz catheter was successfully withdrawn. This case report provides a successful procedure for the removal of the kinked Swan-Ganz catheter, and perspectives on the overall management, such as the possible need for CT examination when difficulty is encountered withdrawing a Swan-Ganz catheter.
Molecular approach of renal cell carcinoma using FISH method : a prospective study (23 cases) and state of the art
Authors: TAYEB Rafik BEN , Mzyiene Mohammed , BOUARDI Nizar , FARHANE Fatimazahra , BOUHAFA Touria , Bouguenouch Laila , MELLAS Nawfel , MAAROUFI Mustapha , FARIH Moulay Hassan , fatemi hinde el 
Published: August 2022

AbstractINTRODUCTION: In Morocco, Kidney cancer is the 18th most common tumour and the 19th lethal cancer in 2020. The average age of diagnosis is 65 years and men are more affected. Molecular studies of renal cell carcinoma (RCC) allowed the detection of several genetic abnormalities in each histological subtype. These aberrations got different diagnostic value, prognostic implication and for some, therapeutic utility. The aim of our study is to evaluate the utility of fluorescence in-situ hybridization (FISH) in the diagnosis and the prognosis of renal cell carcinoma. MATERIAL AND METHODS: We included prospectively cases of RCC diagnosed after histological examination and immunohistochemistry analysis for some cases. The methodology consisted in highlighting by FISH method, molecular abnormalities for each histological subtypes using Zytolight® probes. Probes were chosen depending on the histological diagnosis. RESULTS: A total of 23 case of RCC were included. Clear cell carcinoma (ccRCC) represented 47,8% (11 cases) followed by papillary RCC (pRCC) with 26%, chromophobe RCC (chRCC) with 13%, a case with uncertain diagnosis, ccRCC or pRCC (4,3%), one case of renal oncocytoma (RO) (4,3%), and a case of tubulo-cystic RCC (4,3%). FISH method supported the morphological diagnosis in all cases except in one biopsy diagnosed histologically as a ccRCC and this method allowed the diagnosis correction to pRCC by the detection of chromosome 17 polysomy described in this histological subtype. FISH can also be used in the prognostic categorization of patients by detecting of some genetic aberrations with a prognostic implication like CDKN2a loss which predict a worse evolution. CONCLUSION: FISH method got an implication in the diagnostic approach of RCC, especially in cases with non-conclusive histology and immunohistochemistry. It can also be used in the prognosis in addition to other histo-prognostic factors. This method will lead to more precision in diagnosis and better care management personalization.
Knowledge and attitudes towards breast milk donation and associated factors among pregnant mothers attending antenatal care at health centers in Addis Ababa, Ethiopia
Authors: Demisse Henok , Ameya Gemechu , Alemayehu Tekletsadik , Estifanos Nathan 
Published: August 2022

Abstract

Background
- The majority of mothers are encouraged to breastfeed their babies, however, the problem with breastfeeding arises when the mother is unable to breastfeed due to numerous physical and emotional barriers to breastfeeding. In this case, providing the infant pastoralized donor human milk is vital. Little is known about pregnant mothers’ attitudes and knowledge about breast milk donation in primary health care facilities in Addis Ababa.
Objective
-To assess the knowledge and attitude towards breast milk donation and associated factors among pregnant mothers attending ANC at public health centers in Addis Ababa, Ethiopia, 2021.
Methods
-Institutional based cross-sectional study was conducted among pregnant mothers attending ANC in selected health centers in Addis Ababa. A simple random sampling technique was used to select the study participants. Pregnant mothers were interviewed using a pretested structured questionnaire. Data were entered using Epi data version 4.6.0.2 and exported to SPSS version 25 for cleansing and analysis. Bivariate logistic regression method was used and the statistical significance was declared at p < 0.05 with a 95% confidence level.
Result
- Knowledge of breast milk donation among pregnant mothers attending antenatal care is 25.5%. Nearly half of the mothers have a positive attitude towards breast milk donation. Those who get a monthly income of 3000 and above are 3.2 times more knowledgeable than those who get less than or equal to 1500 birr [AOR (95% CI) 3.23(1.65, 6.34)]. Those mothers who received counseling about breastfeeding are 3.699 times more knowledgeable than those who didn’t receive [AOR (95% CI) 3.699(2.291, 5.973)]. Women who attend secondary education are 3.5 times more likely to have a positive attitude towards breast milk donation than those who never attend school [AOR (95%CI) 3.563(1.864, 6.811)]. Pregnant women who visited NICU were 3.55 times more likely to have a positive attitude towards breast milk donation than those who didn’t visit NICU [AOR (95%CI) 3.557(2.171, 5.829)].
Conclusion
-Our finding in this study about knowledge towards BMD is 25.5%, whereas nearly half of the study participants have a positive attitude towards breast milk donation. Partner occupation, counseling about breastfeeding, and history of delivering low birth weight or preterm infants was found to have a statistically significant association with knowledge about breast milk donation. Educational status, NICU visit, and history of caesarian section delivery were found to have a statistically significant association with attitudes towards breast milk donation.