bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attitude of young farmers to on-farm business sustainability based on the behavior and success of seeking digital information related to agriculture (case of Lebak Regency, Banten Province-Indonesia)
Authors: Khaerunnisa  , Nurmayulis  , Salampessy Y L A 
Published: February 2022

Abstract
Information and communication technology (ICT) utilization in the agricultural sector is crucial to increase productivity, farming efficiency, and agricultural information seeking. Therefore, increasing the number of young farmers who mastered employing ict is essential. The study was conducted to analyze the attitudes of young farmers in the Lebak Regency towards the sustainability of on-farm business based on the carrying capacity of ICT. The survey engaged 66 young farmers in Lebak Regency, which were drawn by proportional simple random sampling. Path analysis was applied to analyze the data. The result showed young farmers’ behaviour of seeking digital agriculture information directly affects the success of the seeking activities. The success of seeking digital agriculture information affects the attitude of on-farm activity sustainability. The behaviour of seeking digital agriculture information affects the attitudes of young farmers towards the sustainability of on-farm work through the success of seeking digital agriculture information.
Nori solar dryer performance: in relation to the colour of the product
Authors: Utomo Bagus S B , Sinurat Ellya 
Published: February 2022

Abstract
One of the critical steps in nori processing is drying. Nori, a special product from seaweed, requires a special design of a dryer to facilitate an efficient drying room and condition. Ordinary mechanical dryers are not suitable for drying nori and are considerably expensive as well, so that a simple model of the solar dryer was required. This dryer uses renewable energy resource in the form of solar energy which is abundantly available and sound environmentally. The study aimed to test the drying performance of the designed dryer correlated with the quality of the nori produced, especially it’s colour. Performance test was conducted in two days from 8.30 to 16.00 WIT each day with main drying parameters temperature and humidity. The observation was conducted every 30 mins. The quality parameters for nori produced were emphasized on colour and sensory evaluation. It was concluded that the drying conditions performed by the dryer were suitable for drying nori producing nori with acceptable colour and texture.
The effect of variation concentration white oyster mushroom flour for quality yogurt mushroom taro synbiotic during storage
Authors: Setiarto R H B , Widhyastuti N , Risty A R 
Published: February 2022

Abstract
Yoghurt was probiotic drink fermented by Lactobacillus bulgaricus, Streptococcus thermophiles, and Lactobacillus acidophilus. The source of prebiotics was 0.5% taro flour from a previous studied. This studied aims to investigate the effect of variations concentration of white oyster mushroom flour on the quality of synbiotic mushroom taro yogurt during a storage period of 4 weeks. The mushroom flour was added with a concentration of 0%; 0.10%; 0.20%; 0.30%; and 0.40%. The results for the concentration factor of white oyster mushroom flour and storage time had significantly different (p<0.05), namely the viscosity test, total lactic acid titrated, pH, viability lactic acid bacteria, and organoleptic tests. The results for the best mushroom taro yogurt, namely 0.01% white oyster mushroom flour, produced a valued that was not significant with previous studied. The results of the antioxidant test for the mushroom taro yogurt was very weak (ES50 807.50 ppm). There was an increase in dietary fibre content (0.11%), a decrease in total fat content (0.04%), an increase in protein content (0.24%), decrease in moisture content (0.5%), and increased levels of total carbohydrates (0.30%) from mushroom taro yogurt. The results of the quality test of mushroom taro yogurt was in accordance with Indonesian National Standard.
Biotechnological transformation of raw materials with reduced technological properties by proteolytic preparations of various origins
Authors: Ponomarev V , Yunusov E , Ezhkova G 
Published: February 2022

Abstract
The paper expands the information about the effect of proteolytic enzyme preparations on the main properties of collagen-containing meat raw materials. The effect of enzyme proteolytic preparations on the main protein fractions of meat raw materials and native collagen obtained from collagen-containing meat raw materials was studied. The effect of Megaterin and collagenase enzymes on collagen-containing raw materials was studied. In the process of treatment, a decrease in protein content and accumulation of low-molecular-weight hydrolysis products in the samples under study were found. Protein hydrolysates were obtained from fermented collagen-containing raw materials by chemical processing. The effect of the obtained hydrolysates on the functional-technological properties of meat raw materials with reduced functional-technological properties was evaluated. The results showed that the use of protein hydrolysates from fermented collagen-containing raw materials can improve the functional and technological properties of low-grade meat raw materials and opens up broad prospects for their use in the meat industry.The scientific principles of designing recipes and technologies for the production of meat products from fermented meat raw materials are proposed.
Antioxidant activity of young leaves extracts of Lygodium microphyllum on boiling variation
Authors: Widiyantoro Ari , Wahdaningsih Sri , Luliana Sri 
Published: February 2022

Abstract

Lygodium microphyllum is one of the ferns that is often used as raw material for food and traditional medicine. L. microphyllum as food ingredients are usually used in the young leaves. This study aims to determine the antioxidant activity of the young leaves extracts of L. microphyllum by boiling variations.The research method is a pure experiment by extracting the young leaves of L. microphyllum by boiling with variations in temperature (30, 40, and 50°C) and boiling time (10, 15, and 20 minutes).The results showed that boiling at a temperature of 50°C and a boiling time of 20 minutes had the highest antioxidant activity with IC50 99±1.23 µg/mL.
Stylus tip radius and wear estimation using the Rsk or the Rp and Rv parameter of a sine wave (Type C1) standard
Authors: Haitjema Han , Thanki Aditi 
Published: February 2022

Abstract
Determination of the stylus tip radius and its wear or damage is a classical problem in tactile surface topography measurements. The determination of the stylus geometry may be tedious and inconvenient, therefore we looked for an easily applicable method. This study shows that the Rsk parameter and the difference between the Rv and Rp parameter may indicate the stylus tip radius as well as wear when using a sine-wave profile material measure, which is commonly supplied with a roughness tester for calibrating and/or adjusting the vertical amplification coefficient. This effect is derived from theoretical calculations on real and simulated styli and specimens and verified experimentally using two commonly used specimens and stylus tips with radii of nominally 1, 2, 5, and 10 µm. When using a standardized stylus with a nominal 2 µm tip radius and 60° cone angle on a typical C1 reference specimen with nominal parameters Ra = 3 µm and RSm = 100 µm, the Rsk value should be approximately −0.01. Any stylus wear will decrease the measured Rsk value. When the Rsk value decreases to a value of −0.06 or lower it may be time for closer inspection and/or replacement of the stylus.
Ductile-brittle transition at edge cracks (001)[110] in BCC iron under different loading rates in mode I: a 3D atomistic study
Authors: Uhnáková Alena , Machová Anna , Červ Jan , Hora Petr , Joch Jaroslav 
Published: February 2022

Abstract
3D atomistic simulations via molecular dynamics (MD) at temperature of 0 K and 295 K (22 °C) with a high quasi-static loading rate dP/dt of 2.92 kN s−1 show that cleavage fracture is supported by surface emission of oblique dislocations

11

1
¯

011

and by their subsequent cross slip to {112} planes, which increases separation of the (001) cleavage planes inside the crystal. Under the slower loading rate by a factor 5, the crack growth is hindered by twin generation on oblique planes {112} and the fracture is ductile. The MD results explain the contribution of the crack itself to the ductile-brittle transition observed in our fracture experiments on Fe-3wt%Si single crystals of the same orientation and geometry, loaded at the same rates dP/dt as in MD. The loading rates are equivalent to the cross head speed of 5 mm min−1 and 1 mm min−1 used in the experiment. The MD results also agree with the stress analysis performed by the anisotropic LFM and comply with experimental observations.
Screen-printed bismuth telluride nanostructured composites for flexible thermoelectric applications
Authors: Amin A , Huang R , Newbrook D , Sethi V , Yong S , Beeby S , Nandhakumar I 
Published: February 2022

Abstract
We herein report the results of a facile two-step surfactant assisted reflux synthesis of bismuth telluride (Bi2Te3) nanowires (NWs). The as-synthesised NWs had diameters ranging from 70 to 110 nm with a length varying between 0.4 and 3 µm and a preferential lattice orientation of (0 1 5) as determined by grazing incidence x-ray diffraction. We demonstrate for the first time that a solvent/binder paste formulation of N-methyl-2-pyrrolidone/polyvinylidene fluoride (PVDF) is suitable for screen-printing the Bi2Te3 NWs with the potential for the fabrication of flexible thermoelectric (TE) materials. The wt% of PVDF in the composite films was varied from 10% to 20% to identify the optimal composition with a view to achieving maximum film flexibility whilst retaining the best TE performance. The films were screen-printed onto Kapton substrates and subjected to a post-printing annealing process to improve TE performance. The annealed and screen printed Bi2Te3/PVDF NW composites yielded a maximum Seebeck coefficient −192 µV K−1 with a power factor of 34 µW m−1K−2 at 225 K. The flexible screen printed composite films were flexible and found to be intact even after 2000 bending cycles.
localpdb—a Python package to manage protein structures and their annotations
Authors: Ludwiczak Jan , Winski Aleksander , Dunin-Horkawicz Stanislaw 
Published: February 2022

AbstractMotivationThe wealth of protein structures collected in the Protein Data Bank enabled large-scale studies of their function and evolution. Such studies, however, require the generation of customized datasets combining the structural data with miscellaneous accessory resources providing functional, taxonomic and other annotations. Unfortunately, the functionality of currently available tools for the creation of such datasets is limited and their usage frequently requires laborious surveying of various data sources and resolving inconsistencies between their versions.ResultsTo address this problem, we developed localpdb, a versatile Python library for the management of protein structures and their annotations. The library features a flexible plugin system enabling seamless unification of the structural data with diverse auxiliary resources, full version control and powerful functionality of creating highly customized datasets. The localpdb can be used in a wide range of bioinformatic tasks, in particular those involving large-scale protein structural analyses and machine learning.Availability and implementationlocalpdb is freely available at https://github.com/labstructbioinf/localpdb. Documentation along with the usage examples can be accessed at https://labstructbioinf.github.io/localpdb/.
SEPA: signaling entropy-based algorithm to evaluate personalized pathway activation for survival analysis on pan-cancer data
Authors: Li Xingyi , Li Min , Xiang Ju , Zhao Zhelin , Shang Xuequn 
Published: February 2022

AbstractMotivationBiomarkers with prognostic ability and biological interpretability can be used to support decision-making in the survival analysis. Genes usually form functional modules to play synergistic roles, such as pathways. Predicting significant features from the functional level can effectively reduce the adverse effects of heterogeneity and obtain more reproducible and interpretable biomarkers. Personalized pathway activation inference can quantify the dysregulation of essential pathways involved in the initiation and progression of cancers, and can contribute to the development of personalized medical treatments.ResultsIn this study, we propose a novel method to evaluate personalized pathway activation based on signaling entropy for survival analysis (SEPA), which is a new attempt to introduce the information-theoretic entropy in generating pathway representation for each patient. SEPA effectively integrates pathway-level information into gene expression data, converting the high-dimensional gene expression data into the low-dimensional biological pathway activation scores. SEPA shows its classification power on the prognostic pan-cancer genomic data, and the potential pathway markers identified based on SEPA have statistical significance in the discrimination of high- and low-risk cohorts and are likely to be associated with the initiation and progress of cancers. The results show that SEPA scores can be used as an indicator to precisely distinguish cancer patients with different clinical outcomes, and identify important pathway features with strong discriminative power and biological interpretability.Availability and implementationThe MATLAB-package for SEPA is freely available from https://github.com/xingyili/SEPA.Supplementary informationSupplementary data are available at Bioinformatics online.
Anti-CRISPRdb v2.2: an online repository of anti-CRISPR proteins including information on inhibitory mechanisms, activities and neighbors of curated anti-CRISPR proteins
Authors: Dong Chuan , Wang Xin , Ma Cong , Zeng Zhi , Pu Dong-Kai , Liu Shuo , Wu Candy-S , Chen Shixin , Deng Zixin , Guo Feng-Biao 
Published: February 2022

Abstract

We previously released the Anti-CRISPRdb database hosting anti-CRISPR proteins (Acrs) and associated information. Since then, the number of known Acr families, types, structures and inhibitory activities has accumulated over time, and Acr neighbors can be used as a candidate pool for screening Acrs in further studies. Therefore, we here updated the database to include the new available information. Our newly updated database shows several improvements: (i) it comprises more entries and families because it includes both Acrs reported in the most recent literatures and Acrs obtained via performing homologous alignment; (ii) the prediction of Acr neighbors is integrated into Anti-CRISPRdb v2.2, and users can identify novel Acrs from these candidates; and (iii) this version includes experimental information on the inhibitory strength and stage for Acr-Cas/Acr-CRISPR pairs, motivating the development of tools for predicting specific inhibitory abilities. Additionally, a parameter, the rank of codon usage bias (CUBRank), was proposed and provided in the new version, which showed a positive relationship with predicted result from AcRanker; hence, it can be used as an indicator for proteins to be Acrs. CUBRank can be used to estimate the possibility of genes occurring within genome island―a hotspot hosting potential genes encoding Acrs. Based on CUBRank and Anti-CRISPRdb, we also gave the first glimpse for the emergence of Acr genes (acrs).

Database URL
http://guolab.whu.edu.cn/anti-CRISPRdb
CEFR and the ELT practitioner: empowerment or enforcement?
Authors: Savski Kristof 
Published: February 2022

Abstract
Over the last two decades, the Common European Framework of Reference for Languages (CEFR) has become ubiquitous in ELT. In this article, I consider how differences in the way in which the framework is being interpreted by different powerful actors, including governments and for-profit organizations, affect its usability for ELT practitioners, a key segment of its intended audience and thus, at least in theory, key beneficiaries of its spread. I highlight three key paradoxes faced by ELT practitioners working with the framework, relating to whether CEFR is to be seen as a flexible point of reference or a set standard, whether the communicative competence described by CEFR is to be seen in a conventional, universal sense or from a more dynamic contemporary perspective, and whether CEFR is to be seen as associated with prepackaged methods (textbooks) or as a vehicle for the development of local pedagogies. I conclude by calling for deeper awareness of these paradoxes among ELT practitioners to support the productive implementation of CEFR.
Psychosocial workplace factors and alcohol-related morbidity: a prospective study of 3 million Swedish workers
Authors: Almroth Melody , Hemmingsson Tomas , Sörberg Wallin Alma , Kjellberg Katarina , Falkstedt Daniel 
Published: February 2022

Abstract

Background
Psychosocial workplace factors may be associated with alcohol-related morbidity, but previous studies have had limited opportunities to take non-occupational explanatory factors into account. The aim of this study is to investigate associations between job control, job demands and their combination (job strain) and diagnosed alcohol-related morbidity while accounting for several potentially confounding factors measured across the life-course, including education.

Methods
Job control, job demands and job strain were measured using the Swedish job exposure matrix measuring psychosocial workload on the occupational level linked to over 3 million individuals based on their occupational titles in 2005 and followed up until 2016. Cox regression models were built to estimate associations with alcohol-related diagnoses recorded in patient registers.

Results
Low job control was associated with an increased risk of alcohol-related morbidity, while high job demands tended to be associated with a decreased risk. Passive and high-strain jobs among men and passive jobs among women were also associated with an increased risk of alcohol diagnoses. However, all associations were found to be weakened in models adjusted for other factors measured prospectively over the life-course, especially in models that included level of education.

Conclusion
The associations between low job control and high job demands, and the risk of alcohol-related morbidity reflect underlying socioeconomic differences to some extent. Lower job control, however, remained associated with a higher risk of alcohol-related morbidity.
Genome of the Rio Pearlfish (Nematolebias whitei), a bi-annual killifish model for Eco-Evo-Devo in extreme environments
Authors: Thompson Andrew W , Wojtas Harrison , Davoll Myles , Braasch Ingo 
Published: February 2022

Abstract
The Rio Pearlfish, Nematolebias whitei, is a bi-annual killifish species inhabiting seasonal pools in the Rio de Janeiro region of Brazil that dry twice per year. Embryos enter dormant diapause stages in the soil, waiting for the inundation of the habitat which triggers hatching and commencement of a new life cycle. Rio Pearlfish represents a convergent, independent origin of annualism from other emerging killifish model species. While some transcriptomic datasets are available for Rio Pearlfish, thus far, a sequenced genome has been unavailable. Here, we present a high quality, 1.2 Gb chromosome-level genome assembly, genome annotations, and a comparative genomic investigation of the Rio Pearlfish as representative of a vertebrate clade that evolved environmentally cued hatching. We show conservation of 3D genome structure across teleost fish evolution, developmental stages, tissues, and cell types. Our analysis of mobile DNA shows that Rio Pearlfish, like other annual killifishes, possesses an expanded transposable element profile with implications for rapid aging and adaptation to harsh conditions. We use the Rio Pearlfish genome to identify its hatching enzyme gene repertoire and the location of the hatching gland, a key first step in understanding the developmental genetic control of hatching. The Rio Pearlfish genome expands the comparative genomic toolkit available to study convergent origins of seasonal life histories, diapause, and rapid aging phenotypes. We present the first set of genomic resources for this emerging model organism, critical for future functional genetic, and multiomic explorations of “Eco-Evo-Devo” phenotypes of resilience and adaptation to extreme environments.
Constructing nuclear responsibility in US–India relations
Authors: Hamidi Sidra 
Published: February 2022

Abstract
In 2005, the United States recognized India as a ‘responsible state with advanced nuclear technology’. How did India go from pariah to a legitimate nuclear state? This article historicizes the concept of nuclear responsibility to explain India's shifting place in the nuclear regime. Existing perspectives view responsibility as a function of discrete state behaviors to the detriment of understanding the relationship between power and responsibility as a discourse. This article tracks the evolving discourse of early proliferators, such as the US, UK and France, who legitimated their possession of nuclear weapons by linking responsibility with deterrence. In its early nuclear history, India challenged these hegemonic perspectives but more recently adopted the deterrence model of responsibility to be granted recognition and legitimacy in the global nuclear regime. The article concludes that nuclear states’ success in linking deterrence with responsibility complicates the place of disarmament as an alternative nuclear responsibility discourse. Tying deterrence to responsibility reshaped the global order around the continual presence of nuclear weapons, narrowing moral agency and limiting a nuclear weapon-free future. Reclaiming responsibility will require moving beyond the typical state-centric politics of blame towards institutional and structural approaches to moral agency.
Early Pouchitis Is Associated With Crohn’s Disease–like Pouch Inflammation in Patients With Ulcerative Colitis
Authors: Kayal Maia , Kohler David , Plietz Michael , Khaitov Sergey , Sylla Patricia , Greenstein Alexander , Dubinsky Marla C 
Published: February 2022

Abstract

Background
Despite the initial diagnosis of ulcerative colitis (UC), approximately 10% to 20% of patients develop Crohn’s disease–like pouch inflammation (CDLPI) after restorative proctocolectomy (RPC) with ileal pouch anal anastomosis (IPAA). The aim of this study was to evaluate whether early pouchitis, defined as pouchitis within the first year after IPAA, is a predictor of CDLPI.

Methods
This was a retrospective cohort analysis of patients with UC or IBD unclassified (IBDU) who underwent RPC with IPAA at Mount Sinai Hospital between January 2008 and December 2017. The primary outcome was development of CDLPI. Predictors of CDLPI were analyzed via univariable and multivariable Cox regression models.

Results
The analytic cohort comprised 412 patients who underwent at least 1 pouchoscopy procedure between 2009 and 2018. Crohn’s disease–like pouch inflammation developed in 57 (13.8%) patients a median interval of 2.1 (interquartile range, 1.1-4.3) years after surgery. On univariable analysis, older age at colectomy (hazard ratio [HR], 0.97; 95% CI, 0.95-0.99) was associated with a reduced risk of CDLPI; although early pouchitis (HR, 2.43; 95% CI, 1.32-4.45) and a greater number of pouchitis episodes (HR, 1.38; 95% CI, 1.17-1.63) were associated with an increased risk. On multivariable analysis, early pouchitis (HR, 2.35; 95% CI, 1.27-4.34) was significantly associated with CDLPI. Time to CDLPI was significantly less in patients who developed early pouchitis compared with those who did not (P = .003).

Conclusion
Early pouchitis is significantly associated with subsequent CDLPI development and may be the first indication of enhanced mucosal immune activation in the pouch.