bluuebunny/crossref_metadata_2025_split huggingface dataset:
A qualitative study exploring clinicians’ views on clinical trials in thumb carpometacarpal joint osteoarthritis
Authors: Dean Benjamin J. F. , Srikesavan Cynthia , Horton Robin , Toye Francine 
Published: April 2022

Aims Osteoarthritis (OA) affecting the thumb carpometacarpal joint (CMCJ) is a common painful condition. In this study, we aimed to explore clinicians’ approach to management with a particular focus on the role of specific interventions that will inform the design of future clinical trials. Methods We interviewed a purposive sample of 24 clinicians, consisting of 12 surgeons and 12 therapists (four occupational therapists and eight physiotherapists) who managed patients with CMCJ OA. This is a qualitative study using semi-structured, online interviews. Interviews were audio-recorded, transcribed verbatim, and analyzed using thematic analysis. Results A total of 14 themes were developed, six of which were developed relating to the clinical management of CMCJ OA: 1) A flexible ‘ladder’ approach starting with conservative treatment first; 2) The malleable role of steroid injection; 3) Surgery as an invasive and risky last resort; 4) A shared and collaborative approach; 5) Treating the whole person; and 6) Severity of life impact influences treatment. The remaining eight themes were developed relating to clinical trial barriers and facilitators: 1) We need to embrace uncertainty; 2) You are not losing out by taking part; 3) It is difficult to be neutral about certain treatments; 4) Difficult to recruit to ‘no treatment’ ; 5) Difficult to recruit to a trial comparing no surgery to surgery; 6) Patients are keen to participate in research; 7) Burden on staff and participants; and 8) A enthusiasm for a variety of potential trial arms. Conclusion Our findings contribute to a better understanding of how clinicians manage thumb CMCJ OA in their practice settings. Our study also provides useful insights informing the design of randomized clinical trials involving steroid injections and surgery in people with thumb CMCJ OA. Cite this article: Bone Jt Open 2022;3(4):321–331.
The life experience of leprosy families in maintaining interaction patterns in the family to support healing in leprosy patients in Indonesian society. A phenomenological qualitative study
Authors: Nasir Abd , Yusuf Ah , Listiawan Muhammad Yulianto , Makhfudli Makhfudli 
Published: April 2022

Background
Family involvement in overcoming the severity of leprosy is very important in the life of leprosy sufferers in communities who experience the clinical and, psychological, social and behavioral consequences of the disease. However, this need, psychosocial, is felt to be not optimal. This study is to identify how the experiences of family members as caregivers provide assistance to individuals with leprosy in improving healing and maintaining patterns of interaction in the family.

Methods
The design uses qualitative research with in-depth, face-to-face interviews with family members in a semi-structured manner with the hope of obtaining complete data. Using purposive sampling with Participatory Interpretative Phenomenology analysis, there are 12 families with 15 family members consisting of 4 men and 11 women.

Results
This study produced a family theme that tried to follow what would happen to individuals with leprosy, with four sub-categories: 1) Using various coping alternatives to recognize the disease, 2) Family members in the shadow of leprosy, 3) Trying to empathize with other family members. sick, 4) Caring for the emotional response of the family and seeking support.

Conclusions
This analysis shows that deficiency in cognitive aspects can be closed by maintaining a lifestyle in the family through efforts to understand, support, establish communication, increase maximum involvement in restoring self-confidence, especially in individuals with leprosy with psychosocial problems in the family. The results of this study can be used as psychosocial support in maintaining communication between family members to support treatment programs and accelerate the recovery of leprosy.
INTERVENÇÕES FARMACÊUTICAS PARA A PROMOÇÃO DO USO RACIONAL DE MEDICAMENTOS EM HOSPITAIS: UMA REVISÃO
Authors: Andrade Almeida Jullye Christye , Freitas de Andrade Kaio Vinicius 
Published: April 2022

A prática da farmácia clínica é de extrema importância no âmbito hospitalar, tendo em vista a alta demanda de prescrição de medicamentos nesse cenário. Deste modo, intervenções farmacêuticas (IF) podem efetivamente contribuir para otimização da farmacoterapia e uso racional dos medicamentos (URM). O objetivo foi analisar intervenções farmacêuticas em hospitais brasileiros, por meio de revisão integrativa. Buscas foram realizadas no Google Acadêmico durante os meses de setembro a outubro de 2021. Foram incluídos 27 artigos publicados entre os anos de 2001 a 2021. As IF de maior frequência foram: ajuste de dose; a mudança da via de administração; substituição do medicamento; a mudança de horário ou aprazamento; manejo de interações medicamentosas; ajuste na técnica de preparo de medicamentos. Verifi cou-se aceitabilidade das IF superior a 70% em mais de 60% dos estudos revisados. Os resultados obtidos evidenciam a importância do farmacêutico clínico inserido de forma ativa em uma equipe multiprofi ssional. Para isso, é necessária constante atualização profissional visando a obtenção de resultados que contribuam para a melhora da farmacoterapia em hospitais.
FARMACOTERAPIA DA COVID-19: APLICAÇÃO DO REMDESIVIR IN VITRO E IN VIVO
Authors: Rezende Mariana de Almeida Rosa , Cordeiro Alice Ferreira , Sousa Andrey Paradela de , Silveira Isadora Valério da 
Published: April 2022

O novo coronavírus (SARS-CoV-2) é um patógeno causador da síndrome respiratória aguda grave em humanos (COVID-19). Sua eclosão envolveu o mundo de maneira repentina, levando a uma crise pandêmica global. Este artigo de revisão foi desenvolvido para avaliar as evidências e experiências existentes relacionadas a um agente farmacológico já aprovado, chamado remdesivir. As plataformas PubMed, Scopus, Web of Science and SciELO foram utilizadas para pesquisar por combinações de palavras, como “COVID-19 AND Remdesivir” ou “SARS-CoV-2 AND Remdesivir”. Quatro revisores buscaram resultados de maneira independente e extraíram os dados dos estudos selecionados até março de 2021. O remdesivir demonstrou inibir o SARS-CoV-2 in vitro e in vivo, apresentando potencial terapêutico no tratamento de pacientes hospitalizados com COVID-19, embora tenha sido associado ao desenvolvimento de efeitos adversos.
Asymptotic mean-value formulas for solutions of general second-order elliptic equations
Authors: Blanc Pablo , Charro Fernando , Manfredi Juan J. , Rossi Julio D. 
Published: April 2022

Abstract
We obtain asymptotic mean-value formulas for solutions of second-order elliptic equations. Our approach is very flexible and allows us to consider several families of operators obtained as an infimum, a supremum, or a combination of both infimum and supremum, of linear operators. The families of equations that we consider include well-known operators such as Pucci, Issacs, and k-Hessian operators.
Das Bibliothekswesen im höchstgelegenen Staat der Welt – ein Überblick über Nepals Bibliothekslandschaft
Authors: Scheler Luisa 
Published: April 2022

Zusammenfassung
Über Nepals Bibliothekswesen ist im Allgemeinen recht wenig bekannt, die Informationslage schwierig. Im nachfolgenden Artikel soll das Bibliothekswesen eines der ärmsten Länder der Welt schlaglichthaft in den Bereichen der Öffentlichen und Wissenschaftlichen Bibliotheken sowie der Bibliothekarischen Ausbildung und ausgewählter Akteure näher beleuchtet werden. Die Ausführungen sollen hierbei als Überblick dienen und sind keineswegs als vollständig anzusehen.
Impact of subspecialty consultations on diagnosis in the pediatric intensive care unit
Authors: Ramesh Sonali , Ayres Brennan , Eyck Patrick Ten , Dawson Jeffrey D. , Reisinger Heather Schacht , Singh Hardeep , Herwaldt Loreen A. , Cifra Christina L. 
Published: April 2022

Abstract

Objectives
Intensivists and subspecialists often collaborate in diagnosing patients in the pediatric intensive care unit (PICU). Our objectives were to characterize critically ill children for whom subspecialty consultations were requested, describe consultation characteristics, and determine consultations’ impact on PICU diagnosis.

Methods
We performed a retrospective study using chart review in a single tertiary referral PICU including children admitted for acute illness. We collected data on patients with and without subspecialty consultations within the first three days of PICU admission and determined changes in PICU clinicians’ diagnostic evaluation or treatment after consultations.

Results
PICU clinicians requested 152 subspecialty consultations for 87 of 101 (86%) patients. Consultations were requested equally for assistance in diagnosis (65%) and treatment (66%). Eighteen of 87 (21%) patients with consultations had a change in diagnosis from PICU admission to discharge, 11 (61%) attributed to subspecialty input. Thirty-nine (45%) patients with consultations had additional imaging and/or laboratory testing and 48 (55%) had medication changes and/or a procedure performed immediately after consultation.

Conclusions
Subspecialty consultations were requested during a majority of PICU admissions. Consultations can influence the diagnosis and treatment of critically ill children. Future research should investigate PICU interdisciplinary collaborations, which are essential for teamwork in diagnosis.
Preparation and applications of hydrophilic quaternary ammonium salt type polymeric antistatic agents
Authors: Zhang Chenming , Cui Yihua , Lin Shiping , Guo Jianwei 
Published: April 2022

Abstract
A novel ammonium salt type polymeric antistatic agent (PDSH) was synthesized from methacrylatoethyl trimethyl ammonium chloride, styrene, and 2-hydroxyethyl methacrylate via radical polymerization. Antistatic poly(acrylonitrile-co-butadiene-co-styrene) (ABS)/PDSH composites were prepared by blending PDSH with ABS resin. The results showed that the surface resistivity of ABS/PDSH composites with PDSH addition decreased significantly. The surface resistivity of ABS/PDSH composites containing 20 wt% PDSH was around 109–1010 Ω, which was about 106 times lower than that of neat ABS. At the same time, ABS/PDSH composites had good thermal stability and hydrophilicity. The PDSH was more uniformly dispersed within the ABS resin and had less influence on the mechanical properties of the composites. With the demonstrated properties, the prepared copolymer PDSH can serve as a well-integrated antistatic agent and display potential for the antistatic treatment of ABS.
Foreign language ideology and American Sign Language in US public education
Authors: Rosen Russell Scott 
Published: April 2022

AbstractAmerican Sign Language has been used at schools and programs for signing deaf and hard of hearing students in US history. Recently, American Sign Language (ASL) was offered as a foreign language to students who speak and hear for foreign language credit at American secondary schools. The movement of the language from its place in deaf education to one of the foreign languages taught in public general education is due to changing ideologies about ASL as a language and as a foreign language. Studies in spoken foreign language ideologies in education presumed ties between languages and national and sub-national ethnic and migrant language groups. No national and sub-national ethnic and migrant language groups have sign language as their mother tongue or are dominated by a signing populace. It raises theoretical issues in foreign language ideology, education, and sign language. Theoretical implications of this study for foreign language ideologies in education are discussed.
General complex Lp
projection bodies and complex Lp
mixed projection bodies
Authors: Cheng Manli , Yang Wenjing , Zhou Yanping 
Published: April 2022

Abstract
Abardia and Bernig proposed the notions of complex projection body and complex mixed projection body. In this paper, we introduce the concepts of the general complex

L

p

{L}_{p}

projection body and complex

L

p

{L}_{p}

mixed projection body. Furthermore, we establish the Brunn-Minkowski-type inequalities for the general complex

L

p

{L}_{p}

projection bodies and the Aleksandrov-Fenchel-type inequalities for the general complex

L

p

{L}_{p}

mixed projection bodies.
Ghost Children: Delayed Personhood and Culture-specific Models of Infancy in Western Anatolia
Authors: Cveček Sabina , Schwall Christoph 
Published: April 2022

Abstract
Most societies view infants and partially children, up to a certain age, as not fully human beings and/or persons. This paper takes a longue durée perspective to examine built spaces shared by the living and dead infants during the four millennia (seventh to third millennium BC) in Anatolia. Evidence of infant burials within and around houses in several prehistoric periods and sites is analysed through a child-centred approach to mortuary remains, which does not equate adults with subadults or fully human with not fully human beings. This allows us to gain new perspectives of how age, age groups and infancy or childhood were perceived in prehistory. By perceiving houses as social spaces where ritual and non-ritual mimesis is embodied in shared practices and beliefs, where the material and social collide, rather than simply as signifiers of social units, we are better able to grasp subadult identities and decipher the personhood of infants and children through mortuary practices. Through our Anatolian case study, we provide socio-anthropological explanations for keeping the ‘ghost children’, buried close to houses, due to delayed personhood. We argue for constructing culture-specific models of infancy based on the archaeological evidence in Anatolia and beyond.
Structure of News Text on the Arrest of the Head of Front Pembela Islam in Online Media
Authors: Putriyanti Lina 
Published: April 2022

The study was to find and describe the structure of the news text on the arrest of the Front Pem-bela Islam chairman in cases of violating health protocols in the midst of the Covid-19 pandemic on BBC News Indonesia and Kompas.com online media. The research was a descriptive qualitative by utilizing van Dijk's model with a social cognition approach focusing on the text schemes which included macro structure, superstructure, and micro structure. The research data were the fragments of discourse of articles on online media BBC News Indonesia and Kompas.com which contained news of healt protocals violations. The re-search applied listening technique and a note-taking technique as a follow-up. To check the re-search data, triangulation and interactive analysis techniques were needed to analyze the data. This study foud out that the online media BBC News Indonesia and Kompas.com had a macro structure regarding the arrest of Rizieq Shihab for violating one of the Covid 19 health protocols, that was gathering crowds. the superstructure was found in the introduction, content, and clos-ing; the microstructure section was found in semantics (background and intent), syntax (sentence forms and pronouns), lexicon, and graphics. The study concluded that according to the Teun A van Dijk scheme, the news on Rizieq Shihab's health protocol violations during the Covid 19 pandemic of BBC News Indonesia and Kompas.com had a macro text structure, superstructure, and micro structure.
The Negative Impact of Monodisciplinary Tradition in Arabic Language and Literature Studies
Authors: Kamil Sukron 
Published: April 2022

As the title suggests, this paper discussed the monodisciplinary tradition of studying Arabic language and literature which became an obstacle for scientific publications or other dissemina-tion activities. The qualitative study made a library research design whose primary data sourced from journal articles, books, research proposals/thesis, and online sources. Careful reading and analysis were applied to get the intended data useful in answering the problems being investigated. The collect-ed data and relevant information were qualitatively analyzed using Ricoeur’s Hermeneutics. The found out many negative consequences of the using of a monodisciplinary study. In general, the study of Arabic language and literature had lack of research significance, depth of analysis, and criticism. It was neither lack of originality nor creativity. In addition to the mono-disciplinary study tradition factor, the teaching university paradigm and poor learning traditions became an-other contributing factor. A mono-disciplinary in studying Arabic language and literature did not contribute significantly to its development. It was necessary to use multidisciplinary intra/interdisciplinary paradigm as a trend in the teaching and studying of Arabic language and literature in the world by which various shortcomings lessened.
Diversidad de empresas agroindustriales rurales: tipologías de producción de panela en Huila, Colombia
Authors: Polo-Murcia Sonia Mercedes , Rodríguez-Borray Gonzalo Alfredo , Cruz-Castiblanco Ginna Natalia , Tauta-Muñoz José Luis , Huertas-Carranza Bellanid 
Published: April 2022

Introducción. Las tipologías se pueden utilizar como un mecanismo para abordar la heterogeneidad de los sistemas agrícolas. La panela o azúcar de caña no centrifugado, es un edulcorante tradicional de gran importancia económica y cultural en Colombia, genera 236 000 empleos directos al año y se produce en 47 % de los municipios del país. Objetivo. Identificar tipologías de unidades de producción agroindustrial (UPA) de panela con base en características técnicas y socioeconómicas en el departamento de Huila, Colombia. Materiales y métodos. Se utilizó la técnica estadística multivariada de análisis factorial de datos mezclados (AFDM) con datos de 94 UPA, tomados de una encuesta representativa de corte transversal del año 2019 realizada en el marco del presente estudio. La encuesta proporcionó información sobre variables del ciclo productivo, socioeconómicas y de manejo ambiental de sub-productos. Resultados. Se identificaron tres tipos diferenciados de UPA: tipo 1(6 UPA- 6,38 %), compuesto por unidades orientadas a la diversificación productiva y transición tecnológica; tipo 2 (63 UPA-67,02 %): compuesto por unidades con manejo tradicional del cultivo, el proceso y el uso de subproductos; y tipo 3 (25 UPA-26,6 %): integrado por unidades especializadas en la producción de panela, con mayor tecnificación en cultivo y procesamiento de la caña de azúcar. Conclusiones. Se identificaron grupos heterogéneos de unidades de producción agroindustrial de panela en el departamento de Huila, Colombia, donde se desarrolla un modelo operativo de pequeña escala de carácter tradicional. La exploración empírica de esta investigación permitió delinear el potencial de adopción de tecnologías en los grupos identificados. Los programas de transferencia de tecnología deben considerar las características técnicas y socioeconómicas de las UPA.
Optimization of functional compounds extraction from Ginkgo biloba seeds using response surface methodology
Authors: Xu Hao-Rui , Zhang Yu-Qi , Wang Shuai , Wang Wei-Dong , Yu Nan-Nan , Gong Hao , Ni Zai-Zhong 
Published: April 2022

Ginkgo biloba seeds are important raw material for foods and medicines. A response surface method was used to obtain the following optimized extraction conditions for Ginkgo biloba seed extracts (GBSE) with the highest 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability: 0.08 g/mL material-to-liquid ratio, 70% ethanol concentration, 47°C extraction temperature and extraction time of 22 min. Fourier transform infrared spectroscopy revealed the polysaccharide structure of GBSE from three varieties of Ginkgo biloba seeds (Fozhi, Maling and Yuanling seed varieties). The extract yield, polysaccharides, total phenolics and total flavonoids in the three varieties were 5.77–6.11%, 11.45–364.69 mg/g, 22.34–25.54 mg/g and 14.87–16.47 mg/g, respectively. The GBSE has good antioxidant ability, including DPPH-reducing activity (1842.73–2616.00 micromol [mmol] Trolox Equivalents [TE]/gram [g]), ABTS (2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid); 185.03–217.63 mmol TE/g) and ferric-reducing antioxidant power (FRAP; 220.46–230.77 mmol TE/g). This study provides a method for preparing GBSE with high antioxidant activity and improving the utilization value of Ginkgo biloba seeds.
Acceptance, effects, and tolerability in the vaccination process against SARS-CoV-2 virus among cancer patients in Bosnia and Herzegovina: a single-center cross-sectional study
Authors: Ceric Timur , Sokolović Emir , Pašić Anes , Borovac-Gurda Emina , Smajlbegović Velda , Hasanbegović Berisa , Bičakčić Filipović Emina , Kapisazović Elma , Sokolović Selma , Bešlija Semir 
Published: April 2022

The pandemic of SARS-CoV-2 has been the main health public issue since the end of 2019. Vaccination campaign in B&H started in April 2021 with several vaccines available. Our study aimed to evaluate acceptance, effects and tolerability of vaccines against SARS-COV 2 virus among cancer patients. We have conducted cross-sectional, observational study between 22nd October and 30th November 2021 at the Clinic of Oncology, Clinical Center University of Sarajevo. Patients were randomly enrolled during their regular visit to the Clinic of Oncology by agreeing to fill in an individual paper questionnaire. The study included 1063 patients with malignant disease of which 681 (64.1%] were fully vaccinated patients. In study population 76.9% of patients reported that they did not have any side effects of vaccination, while only 0.5% of patients had delay in their treatment caused by side effects of vaccination. Among fully vaccinated patients there were 40 patients (3.8%] who were infected with SARS-CoV-2 after the second or booster dose of vaccine. Five patients (0.5%] were hospitalized because of COVID-19 after being fully vaccinated. Findings of our study suggest that cancer patients have higher acceptance of vaccines against SARS-CoV-2 than general population in Bosnia and Herzegovina. Side effects of vaccines are tolerable and do not cause major delay of specific cancer treatment. Protective effects of SARS-CoV-2 vaccines in cancer patients presented in our study are comparable to available results of similar studies which included general population.
Infant stimulation reduces weight loss and increases breastfeeding: a randomized controlled trial
Authors: Vesga Gualdrón Lucy Marcela , Durán de Villalobos María Mercedes , Bernal Camargo Nancy Milena 
Published: April 2022

Objective. The study aimed to measure the effect of auditory, tactile, visual, and vestibular (ATVV) stimulation therapy on sucking effectiveness (SE), infant-feeding mode, weight, height, and head circumference (HC) of full-term infants.
Methods. A single-blinded randomized trial with a sample of 107 mother-child dyads. Inclusion criteria were healthy first-time mothers and full-term infants with no known pathological conditions, weighing between 2500 and 4000 grams, and recommendation of exclusive or predominant breastfeeding. The mothers in the experimental group (EG) received training in ATVV stimulation therapy and provided it from birth (first 24 hours of life) until the end of the follow-ups at week 5. The control group (CG) received only standard care that included education on warning signs and basic guidance on breastfeeding. SE, infant-feeding mode, and neonatal growth were measured at weeks 2 and 5.
Results. In contrast to CG infants, the EG infants drank 2.02 cc more human milk in one minute of effective breastfeeding (p=0.002) at week 2 and 5.51 cc more at week 5 (p<0.0001). They showed greater adherence to breastfeeding at week 5 (p=0.025) and gained more weight: 8.35 grams/day (p=0.009) and 4.19 grams/day (p=0.008). HC did not differ between groups, and height difference was statistically significant at week 5 (p=0.025).
Conclusion. ATVV stimulation therapy has a positive effect on neonatal health as it promotes effective sucking and exclusive breastfeeding, reduces weight loss, and improves neonatal growth.