bluuebunny/crossref_metadata_2025_split huggingface dataset:
Air pollution in Sarajevo, Bosnia and Herzegovina, assessed by plant comet assay
Authors: Hasanovic Mujo , Cetkovic Tamara , Pourrut Bertrand , Caluk Klacar Lejla , Hadzic Omanovic Maida , Durmic-Pasic Adaleta , Haveric Sanin , Haveric Anja 
Published: November 2022

Abstract
Bosnia and Herzegovina (B&H) is among the European countries with the highest rate of air pollution-related death cases and the poorest air quality. The main causes are solid fuel consumption, traffic, and the poorly developed or implemented air pollution reduction policies. In addition, the city of Sarajevo, the capital of B&H, suffers temperature inversion episodes in autumn/winter months, which sustain air pollution. Human biomonitoring studies may be confounded by the lifestyle of subjects or possible metabolic alterations. Therefore, this study aimed to evaluate Ligustrum vulgare L. as a model for air pollution monitoring by measuring DNA damage at one rural and two urban sites. DNA damage was measured as tail intensity (TI) in L. vulgare leaves, considering seasonal, sampling period, leaf position and staging, and spatial (urban versus rural) variation. Effects of COVID-19 lockdown on TI were assessed by periodical monitoring at one of the selected sites, while in-house grown L. vulgare plants were used to test differences between outdoor and indoor air pollution effects for the same sampling period. Significantly higher TI was generally observed in leaves collected in Campus in December 2020 and 2021 compared with March (P &lt; 0.0001). Outer and adult leaves showed higher TI values, except for the rural site where no differences for these categories were found. Leaves collected in the proximity of the intensive traffic showed significantly higher TI values (P &lt; 0.001), regardless of the sampling period and the stage of growth. In regards to the COVID-19 lockdown, higher TI (P &lt; 0.001) was registered in December 2020, after the lockdown period, than in periods before COVID-19 outbreak or immediately after the lockdown in 2020. This also reflects mild air pollution conditions in summer. TI values for the in-house grown leaves were significantly lower compared to those in situ. Results showed that L. vulgare may present a consistent model for the air pollution biomonitoring but further studies are needed to establish the best association between L. vulgare physiology, air quality data, and air pollution effects.
Sweet Syndrome Imitating Cutaneous Cryptococcal Disease
Authors: Jordan Ariel A , Graciaa Daniel S , Gopalsamy Srinivasa N , Neill Stewart G , Parker Douglas C , Aspey Laura D , Collins Jeffrey M 
Published: November 2022

Abstract
Cryptococcoid Sweet syndrome is a rare histologic variant of the neutrophilic dermatosis presenting clinically with skin lesions typical of classical Sweet syndrome but with yeast-like structures suggestive of Cryptococcus on histopathology. Histochemical stains for fungus and cultures are negative whereas staining for myeloperoxidase is positive. We present 2 cases of cryptococcoid Sweet syndrome with atypical skin manifestations, including hemorrhagic bullae and plaques, and provide a brief review of the literature. Clinicians should be aware that this variant of Sweet syndrome can present with uncommon clinical findings and has histopathologic findings suggestive of Cryptococcus species.
Towards a Phenomenology of Rasa
Authors: Kaur Inderjit N. 
Published: November 2022

Abstract
Rasa (flavor, essence), as a concept in the Indian aesthetics of performance, is as widely known as the notions of raga and tala. Yet, the lived experience of rasa in the everyday remains seriously underexplored. This essay pursues a phenomenology of rasa by presenting an ethnographic investigation of the phenomenon of ras (rasa’s vernacular counterpart) in the practice of Sikh sabad kīrtan (sung scriptural verse). It proposes that ras can be understood as an interrelational experience that emerges in a phenomenal field co-constituted by people, objects, sound, food, ideas, memory, and aspirations. Focusing on what I call the “ethical flavors” of non-Othering in har-ras (divine-ras) and resilience in vīr-ras (heroic-ras), the essay explicates ras as the body’s mode of inhabiting the lived world. It illuminates the epistemic value of ras in gaining knowledge of self, community, and the divine, and explores the temporal dimension of ras as it accretes in the body to continue to be productive in the overlapping phenomenal fields of everyday social and political life.
XVIINew Literatures
Authors: Egbunike Louisa Uchum , Lorre-Johnston Christine , Manzo Kerry , McNeill Dougal , Miller Benjamin , Narumi Naruse Cheryl , NivesjÖ Sanja , Niblett Michael , Raja Ira , Sharrad Paul , GARCÍA Zarranz Libe , Zirra Maria 
Published: November 2022

AbstractThis chapter has seven sections: 1. Africa; 2. Australia; 3. Canada; 4. The Caribbean; 5. South Asia: The Indian Subcontinent and Sri Lanka; 6. New Zealand and Pacific; 7. Southeast Asia. Section 1 is by Louisa Uchum Egbunike, Kerry Manzo, Sanja Nivesjö, and Maria Zirra; section 2 is by Benjamin Miller and Paul Sharrad; section 3 is by Christine Lorre-Johnston and Libe García Zarranz; section 4 is by Michael Niblett; section 5 is by Ira Raja; section 6 is by Dougal McNeill; section 7 is by Cheryl Narumi Naruse.
Completeness and Mismatch of Patient-Important Outcomes After Trauma
Authors: James Arthur , Ravaud Philippe , Riveros Carolina , Raux Mathieu , Tran Viet-Thi 
Published: November 2022

Background:
To assess the completeness of the collection of patient-important outcomes and the mismatch between outcomes measured in research and patients’ important issues after trauma.

Summary Background Data:
To date, severe trauma has mainly been assessed using in-hospital mortality. Yet, with 80 to 90% survivors discharged from hospital, it is critical to assess the collection of patient important long-term outcomes of trauma.

Methods:
Mixed methods study combining a systematic review of outcomes and their comparison with domains elicited by patients during a qualitative study. We searched Medline, EMBASE and clinicaltrials.gov from January 1, 2014 to September 30, 2019 and extracted all outcomes from reports including severe trauma. We compared these outcomes with 97 domains that matter to trauma survivors identified in a previous qualitative study. We defined as patient-important outcome as the 10 most frequently elicited domains in the qualitative study. We assessed the number of domains captured in each report to illustrate the completeness of the collection of patient-important outcomes. We also assessed the mismatch between outcomes collected and what matters to patients.

Findings:
Among the 116 reports included in the systematic review, we identified 403 outcomes collected with 154 unique measurements tools. Beside mortality, measurement tools most frequently used were the Glasgow Outcome Scale (31.0%, n=36), questions on patients’ return to work (20,7%, n=24) and the EQ-5D (19.0%, n=22). The comparison between the outcomes identified in the systematic review and the domains from the qualitative study found that 10.3% (n=12) reports did not collect any patient-important domains and one collected all 10 patient-important domains. By examining each of the 10 patient-important domains, none was collected in more than 72% of reports and only five were among the ten most frequently measured domains in studies.

Conclusion:
The completeness of the collection of the long-term patient-important outcomes after trauma can be improved. There was a mismatch between the domains used in the literature and those considered important by patients during a qualitative study.
Patient Education on Scarring Following Mohs Micrographic Surgery: Patient Preference for Information Delivery
Authors: Aleisa Abdullah , Veldhuizen Inge J. , Rossi Anthony M. , Nehal Kishwer S. , Lee Erica H. 
Published: November 2022

BACKGROUND
There are multiple modalities for patient education ranging from written to audiovisual formats. However, little is known regarding which modality is optimal.

OBJECTIVE
To assess patient preference for educational materials about scar care following surgery for facial skin cancer using the FACE-Q Skin Cancer patient reported outcome measure.

MATERIALS AND METHODS
On the day of Mohs surgery, patients were given a written handout or viewed a 3-minute animation video regarding best practices in scar improvement. Afterward, patients received the FACE-Q Skin Cancer—Satisfaction with Information: Appearance scale. Three months later, patients were called and given the same scale and additional questions regarding scar care.

RESULTS
A total of 75 patients were enrolled. There was no difference between the 2 groups' preoperative information scores (p = .85) and the three-month postoperative scores (p = .37). The change in preoperative and postoperative score showed no significant difference between the 2 groups (p = .21); but there was a trend of higher satisfaction in the video group on the day of Mohs surgery. After the 3-month timepoint, there was a higher satisfaction trend observed with the written handout group.

CONCLUSION
Patient preferences in information delivery and accessibility will contribute to greater information retention and satisfaction.
Bupivacaine to Reduce Pain and Narcotic Use After Mohs Micrographic Surgery
Authors: Voss Vanessa B. , Oh Clara , Veerabagu Surya , Nugent Shannon , Giordano Cerrene , Golda Nicholas J. 
Published: November 2022

BACKGROUND
Limited data exists for bupivacaine injection after Mohs micrographic surgery (MMS).

OBJECTIVE
Evaluate how bupivacaine affects postoperative pain and narcotic use.

MATERIALS AND METHODS
In this multicenter, single-blinded, prospective randomized controlled trial, patients received bupivacaine or saline (placebo) immediately after MMS with flap reconstructions identified by American Academy of Dermatology expert consensus as high-risk for pain and narcotic use. For 48 hours postoperatively, patients logged analgesic use, pain scores (0–10), and whether pain was controlled.

RESULTS
One hundred seventy-four patients were included. Narcotic analgesic use was higher in the placebo group during the first 24 hours (odds ratio 2.18; confidence interval [CI]: 1.08–4.41; p = .03), second 24 hours (odds ratio 2.18; CI: 0.91–5.29; p = .08), and 48 hours combined (odds ratio 2.58; CI: 1.28–5.24; p < .01). Pain scores were lower in the bupivacaine group during the first 8 hours (mean difference 1.6; CI: 0.73–2.38; p < .001). Overall analgesic use (narcotic and non-narcotic) and percentage of patients reporting pain under control were similar between groups. There were no significant differences in demographics or surgical characteristics. No adverse events occurred.

CONCLUSION
Single-dose bupivacaine decreased postoperative pain and narcotic analgesic use after MMS with reconstructions likely to cause significant pain. Bupivacaine may have a role in postoperative pain management and reducing narcotic use in this population.
High Patient Satisfaction for up to 6 Months With OnabotulinumtoxinA Treatment for Upper Facial Lines
Authors: Cohen Joel L. , Fagien Steven , Ogilvie Patricia , De Boulle Koenraad , Carruthers Jean , Cox Sue Ellen , Kelly Regina , Garcia Julia K. , Sangha Sara 
Published: November 2022

BACKGROUND
OnabotulinumtoxinA safety and efficacy are well established for upper facial lines (UFL), including forehead lines (FHL), glabellar lines (GL), and crow's feet lines (CFL).

OBJECTIVE
To investigate the association of onabotulinumtoxinA efficacy with patient-reported psychological impacts and satisfaction in UFL.

MATERIALS AND METHODS
A pooled analysis of data from 4 pivotal Phase 3 trials (onabotulinumtoxinA vs placebo in FHL ± GL, FHL + GL ± CFL, CFL, and CFL + GL for ≤180 days) evaluated investigator-assessed ≥1-grade severity improvement on the Allergan Facial Wrinkle Scale at Day 30 (responders). Facial Line Outcomes (FLO-11) Questionnaire, Facial Line Satisfaction Questionnaire (FLSQ), and Subject Assessment of Satisfaction of Appearance (SASA) were used to evaluate responder appearance-related psychological impacts and satisfaction.

RESULTS
OnabotulinumtoxinA patients, by primary study focus (FHL, GL, or CFL), totaled 921, 921, and 833, respectively; 786 patients received placebo. Most patients were female, White, and aged 45 to 50 years (median). Through 150 days, >42% FHL, >43% GL, and ≥32% CFL patients were onabotulinumtoxinA responders. Responders reported improvements in appearance-related psychological impacts (FLO-11) and high satisfaction (FLSQ and SASA), sustained through ≥150 days.

CONCLUSION
A ≥1-grade improvement with onabotulinumtoxinA is a clinically meaningful outcome in UFL, associated with long-lasting improved patient-reported psychological impacts and high satisfaction.
Risk factors for mortality in systemic lupus erythematosus patients: Analysis of adult and pediatric cohorts in Taiwan
Authors: Lai Chien-Chih , Sun Yi-Syuan , Chen Wei-Sheng , Liao Hsien-Tzung , Chen Ming-Han , Tsai Chang-Youh , Huang De-Feng , Chou Chung-Tei , Chang Deh-Ming 
Published: November 2022

Background:
Overall survival of systemic lupus erythematosus (SLE) patients significantly increased in recent decades, however, the relative risk of mortality is still high. Long-term survival outcome of pediatric SLE remains unclear. This study aims to explore the long-term survival rate and its predictors in patients with systemic lupus erythematosus (SLE).

Methods:
A retrospective, hospital-based cohort study was performed between 2004 and 2018 in a tertiary referral medical center in Taiwan. Data on comorbidities, medications, and causes of admission were collected for risk factor analysis using time-dependent multivariate Cox proportional hazards models.

Results:
A total of 2392 adults and 115 pediatric SLE patients were enrolled (female, n = 2157 and 95, respectively). The 10-year survival rates were 93.2%, 90.2%, 98.9%, and 100% in adult women, adult men, girls, and boys with SLE, respectively. The overall mortality rate was 2.09 case/100 patient-years (PY) for male SLE and 1.39 case/100 PY for female SLE patients. Male SLE patients did not have a statistically significantly higher mortality rate than female SLE patients in each age stratification. Infectious disease (n = 119), heart failure (n = 21), and cerebrovascular accident (n = 14) were the leading causes of death in adult SLE patients. Advanced age (hazard ratio [HR]: 1.04, 95% confidence interval [CI]: 1.03-1.05), treatment with mean dosage of systemic glucocorticoid equivalent to >10 mg/d of prednisolone (HR: 1.71, 95% CI: 1.14-2.57), comorbidities with malignancy (HR: 1.94, 95% CI: 1.22-3.09), chronic kidney disease (HR: 1.86, 95% CI: 1.25-2.77), hypertension (HR: 1.42, 95% CI: 1.01-1.98), and admission due to bacterial pneumonia (HR: 1.92, 95% CI: 1.12-3.31) and sepsis (HR: 2.78, 95% CI: 1.51-5.13) were independent risk factors for mortality in SLE patients.

Conclusion:
SLE patients with advanced age, malignancy, chronic kidney disease, hypertension, treated with a higher average dosage of glucocorticoids, and admission due to bacterial pneumonia and sepsis have an increased risk of mortality.
An all-arthroscopic surgery technique for snapping popliteal tendon syndrome: A case report and literature review
Authors: Ryu Ji Hyun , Lee Se-Won , Lee Dong Hwan 
Published: November 2022

Rationale:
The incidence of snapping popliteus tendon syndrome, a type of lateral knee snapping, is not high, so making an accurate diagnosis is difficult. A proper treatment following an accurate diagnosis is essential for improvement. Very few cases have been reported of its treatment.

Patient concerns:
An 18-year-old male patient had experienced painful popping in the lateral part of the knee during knee flexion for 3 years before his hospital visit.

Diagnoses:
Snapping popliteus tendon syndrome.

Interventions:
The patient underwent an all-arthroscopic surgery. Tendon debulking and tissue debridement around the popliteus tendon was conducted, but the snapping did not resolve. The enlarged tubercle was excised through an arthroscopic procedure using a burr, and the surgery was finished after confirming that snapping was resolved.

Outcomes:
Full range of motion (ROM) was recovered 6 weeks after surgery and the snapping did not recur.

Lessons:
Snapping popliteus tendon syndrome is a disease that is hardly recognized due to its low prevalence and difficulty in diagnosis, and it requires close observation of the patient before surgery. The location of the tenderness and the snapping occurrence must also be carefully identified. Our procedure is an entirely arthroscopic technique; as it has the prominent advantage of a speedy recovery and easy rehabilitation, it could also be helpful to set treatment standards for this disease in the future.
Efficacy and safety of immune checkpoint inhibitors combined anti-angiogenic therapy in patients with unresectable hepatocellular carcinoma: A meta-analysis
Authors: Xian Feng , Wu Cailiang , Zhang Guojun , Xu Guohui 
Published: November 2022

Background:
This study aimed to compare the efficacy and safety of immune checkpoint inhibitors (ICIs) combined with antiangiogenic agents in patients with unresectable hepatocellular carcinoma (HCC).

Methods:
We conducted a systematic literature search of articles published between the establishment of the database and February 2022. Data were extracted and analyzed using STATA 14.0.

Results:
Six randomized controlled trials (RCTs) (980 patients for combination therapy and 565 patients for monotherapy) and 5 single-arm studies (246 patients for ICIs combination therapy) were enrolled. The objective response rate (ORR) and disease control rate (DCR) were 26% and 70%, respectively, after ICIs combination therapy. Compared with monotherapy in RCTs, ICIs combination therapy resulted in higher progression-free survival (PFS) and overall survival (OS), but also increased the incidence of adverse events (AEs). Increased incidences of fatigue, hypertension, hyperbilirubinemia, proteinuria, and nausea were more common after ICIs combination therapy.

Conclusion:
The analysis results reveal that ICI-combined anti-angiogenesis therapy has higher efficacy than either ICIs or anti-angiogenesis options for unresectable HCC, but it is necessary to manage the AEs.
Three-year recurrence of Dupuytren’s contracture after needle fasciotomy or collagenase injection: a randomized controlled trial
Authors: Jørgensen Rasmus W , Jensen Claus H , Jørring Stig 
Published: November 2022

Background:
In this randomized controlled trial, we compared the recurrence of Dupuytren’s disease at 3-years following needle fasciotomy or collagenase injection treatment for isolated metacarpophalangeal joint contractures.

Methods:
The study was conducted between 2013 and 2015. The study design was a single centre randomized controlled clinical trial with an independent blinded observer. Patients were randomized between collagenase clostridium histolyticum injections (Xiapex®) and percutaneous needle fasciotomy (CCH vs PNF). A total of 36 patients were followed in the PNF group and 32 in the CCH group.

Results:
Patients who were treated with CCH had a significantly lower recurrence rate than patients treated with PNF during the three-year period (p = 0.007). Of the 36 patients who were followed in the PNF group, 47% (n=17) had recurrence of extension deficit or progression of the disease leading to further treatment. Of the 32 patients who were followed in the CCH group, 19% (n=6) had recurrence or progression. No serious adverse event was reported in any of the patients.

Conclusions:
In this randomized controlled trial, we find less recurrence and progression of Dupuytren’s disease using collagenase injection as compared to percutaneous needle fasciotomy three years following treatment for isolated metacarpophalangeal joint contractures.
Level of evidence: I
18F-FDG and 18F-Fluciclovine Uptake in Poorly Differentiated Lung Adenocarcinoma in the Setting of Biochemically Recurrent Prostatic Adenocarcinoma
Authors: Trak Joseph , Hasanovic Adnan , Gavane Somali 
Published: November 2022

Abstract
A 64-year-old man with a history of Gleason 7 (3 + 4) pT2cN0 prostatic adenocarcinoma status post prostatectomy underwent a fluciclovine PET/CT that showed a tracer-avid right upper lobe spiculated solitary pulmonary nodule. Follow-up FDG PET/CT showed a hypermetabolic right upper lobe spiculated solitary pulmonary nodule. Fine-needle aspiration was consistent with primary lung adenocarcinoma. Subsequently, right upper lobectomy was performed, and poorly differentiated lung adenocarcinoma was confirmed.
Impact of a Multidisciplinary Simulation-Based Training Program on the Multiple Techniques of Intraosseous Access
Authors: Alkhalil Rania , Ouersighni Amina , Kenway Philippe , Breque Cyril , Oriot Denis , Ghazali Daniel Aiham 
Published: November 2022

Objectives
The aim of this study was to assess intraosseous (IO) access placement performance during a multidisciplinary simulation-based training (SBT) program according to the professional status, experience of caregivers, and the setting of the course.

Method
This prospective, multicentric study included emergency physicians, residents, certified registered nurse anesthetists, registered nurses, and students. It was carried out between April 6, 2020 and April 30, 2021 in emergency medical services, an emergency department, and a simulation center. Trainee performance was evaluated by 2 independent observers using a validated scale, before and after SBT. Self-assessment of satisfaction was carried out. Interobserver reproducibility was analyzed by intraclass correlation coefficient. The continuous variables were compared using a Student t test or a nonparametric Mann-Whitney U test. Comparative analysis between the different groups used analysis of variance. Correlation analysis was performed by a nonparametric Spearman test. A P value of 0.05 was considered significant.

Results
Ninety-eight participants were included. Intraclass correlation coefficient between the 2 observers was 0.96. Performance significantly increased after training, regardless of the site or device used (for the semiautomatic device, P = 0.004 in tibia and P = 0.001 in humeral; for the manual device, P < 0.001). Simulation-based training significantly reduced time for IO access (P = 0.02). After SBT, no difference was found according to professional status and the setting of the course. Performance was not correlated with professional experience. All trainees were satisfied with the training.

Conclusions
Simulation-based training improved the IO access using a semiautomatic or a manual device, regardless of the experience or status of the trainees. Simulation-based training would work for many disciplines regardless of locations (simulation or clinical facilities).
Fast ion shuttling which is robust versus oscillatory perturbations
Authors: Espinós H. , Echanobe J. , Lu X.-J. , Muga J. G. 
Published: November 2022

Shuttling protocols designed by shortcut-to-adiabaticity techniques may suffer from perturbations and imperfect implementations. We study the motional excitation of a single ion shuttled in harmonic traps with time-dependent, ‘systematic’ oscillatory perturbations around the nominal parameters. These elementary perturbations could form any other by superposition. Robust shuttling strategies are proposed and compared, and optimizations are performed.
This article is part of the theme issue ‘Shortcuts to adiabaticity: theoretical, experimental and interdisciplinary perspectives’.
Counterdiabatic formalism of shortcuts to adiabaticity
Authors: Nakahara Mikio 
Published: November 2022

A pedagogical introduction to counterdiabatic formalism of shortcuts to adiabaticity is given so that readers can access some of the more specialized articles in the rest of this theme issue without any barriers. A guide to references is given so that this article also serves as a mini-review.This article is part of the theme issue ‘Shortcuts to adiabaticity: theoretical, experimental and interdisciplinary perspectives’.