bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the influence of behavioral aspects on stock investment decision-making: a study on Bangladeshi individual investors
Authors: Hossain Tanzina , Siddiqua Pallabi 
Published: July 2022

PurposeDetermining the impact of behavioral influences on the stock market has significant implications for investment analysis and portfolio management. Behavioral biases are parameters that need to be considered in investment decision-making. The purpose of this study is to inform Bangladeshi investors about behavioral biases that they may encounter when making investment decisions in the prevailing frontier environment.Design/methodology/approachThrough the chi-square test, one-way ANOVA, paired-samples t-test and descriptive analysis based on the facts collected from 281 respondents of the Dhaka Stock Exchange (DSE), the study has found that individual investors of Bangladesh often make investment decisions emotionally rather than based on theories.FindingsThe result shows that risk aversion and risk perception are the two most influential emotional dimensions that impact investors' decisions. The findings are consistent with the other researchers and highlight the fact that investors hardly act according to the norms recommended in the financial theories.Research limitations/implicationsThe findings are grounded on a small portion of investors at DSE on some particular days, which is not sufficient to study individual investors' entire complex decision-making behavior from various angles. Many respondents were reluctant and even confused to disclose their behavioral aspects. These, along with biased and careless answers, may impede the identification of the actual scenario of the behavioral responses in decision-making that demand further study.Originality/valueThe novelty of this study is unique in that it examined investors of the DSE, who are considered to be a representative in a frontier market like Bangladesh. Since this market is not very resilient, small investors need to be aware of the biases of behavioral factors to survive.
A review on pectinase properties, application in juice clarification, and membranes as immobilization support
Authors: Patel Vashishtha B. , Chatterjee Somak , Dhoble Abhishek S. 
Published: July 2022

AbstractPectic substances cause haziness and high viscosity of fruit juices. Pectinase enzymes are biological compounds that degrade pectic compounds. Nontoxicity and ecofriendly nature make pectinases excellent biocatalysts for juice clarification. However, the poor stability and nonreusability of pectinases trim down the effectiveness of the operation. The immobilization techniques have gained the attention of researchers as it augments the properties of the enzymes. Literature has reported the stability improvement of enzymes like lipase, laccase, hydrogen peroxidase, and cellulase upon immobilization on the membrane. However, only a few research articles divulge pectinase immobilization using a membrane. The catalysis‐separation synergy of membrane‐reactor has put indelible imprints in industrial applications. Immobilization of pectinase on the membrane can enhance its performance in juice processing. This review delineates the importance of physicochemical and kinematic properties of pectinases relating to the juice processing parameters. It also includes the influence of metal‐ion cofactors on enzymes’ activity. Considering the support and catalytic‐separation facets of the membrane, the prediction of the membrane as support for pectinase immobilization has also been carried out.
Optimizing the extrusion conditions for the production of expanded intermediate wheatgrass (Thinopyrum intermedium) products
Authors: Boakye Prince G. , Okyere Akua Y. , Kougblenou Ibilola , Kowalski Ryan , Ismail Baraem P. , Annor George A. 
Published: July 2022

AbstractIn this study, the effects of extrusion conditions such as feed moisture content (20%, 24%, and 28%), screw speed (200, 300, and 400 rpm), and extrusion temperature (130, 150, and 170°C) on the physical and functional properties (moisture content, expansion ratio, bulk density, hardness, water absorption index [WAI], water solubility index [WSI]) of intermediate wheatgrass (IWG) were investigated for the first time. Response surface methodology was used to model and optimize the extrusion conditions to produce expanded IWG. The model coefficient of determination (R2) was high for all the responses (0.87–0.98). All the models were found to be significant (p < 0.05) and were validated with independent experiments. Generally, all the extrusion conditions were found to have significant effects on the IWG properties measured. Increasing the screw speed and decreasing the extrusion temperature resulted in IWG extrudates with a high expansion ratio. This also resulted in IWG extrudates with generally low hardness and bulk density. Screw speed was found to have the most significant effect on the WAI and WSI, with increasing screw speed resulting in a significant (p < 0.05) decrease in WAI and a significant (p < 0.05) increase in WSI. The optimum conditions for obtaining an IWG extrudate with a high expansion ratio and WAI were found to be 20% feed moisture, 200 –356 rpm screw speed, and 130–154°C extrusion temperature.Practical ApplicationExtrusion cooking was employed in the production of expanded IWG. This research could provide a foundation to produce expanded IWG, which can potentially be used as breakfast cereals and snacks. This is critical in the efforts to commercialize IWG for mainstream food applications.
Comparison of the effectiveness of soft and hard splints in the symptomatic management of temporomandibular joint disorders: A randomized control study
Authors: Poorna T Anish , John Bobby , E K Joshna , Rao Arun 
Published: July 2022

AbstractAimSplint therapy is a well‐established modality in the management of temporomandibular joint disorders (TMDs). We aimed to evaluate and compare the effectiveness of hard and soft splints in the symptomatic management of TMDs using the modified Helkimo index.MethodsThis study included 91 patients diagnosed with TMDs. Participants were randomly allocated into two treatment groups. All these patients were treated by hard or soft stabilization splint therapy. Group 1: hard splint group, n = 42 (mean age ‐ 31.62 ± 8.5 years), 10 males and 32 females; group 2: soft splint group, n = 49 (mean age ‐ 32.86 ± 9.06 years), 13 males and 36 females. The anamnestic and clinical dysfunction component of the modified Helkimo index was used to evaluate the outcomes at baseline (T0), first month (T1), and third month (T2).ResultsSymptoms such as clicking of the joints, temporomandibular joint (TMJ) pain and muscle pain showed improvement in both groups (P < .05). Restriction and deviation of mouth opening did not show significant improvement in either group. The patients who underwent hard splint therapy showed an early improvement of symptoms at T1 (P < .05). However, there was no statistical difference in the improvement of symptoms between hard and soft splints at T2.ConclusionBoth hard and soft stabilization splints were effective in the symptomatic management of TMDs. However, hard splints provide an earlier reduction of symptoms.
How close is danger? Relationship between the distance from an exotic tree plantation and occupancy of an endemic lizard
Authors: de Oliveira Arthur Schramm , Guimarães Murilo , Matias Nathalia Rocha , Verrastro Laura 
Published: July 2022

AbstractSilviculture is among the human activities that contribute most to fragmentation and habitat loss. The comprehension of the effects of such activity on the environment is crucial for conservation. Here, we assessed the effects of silviculture on the local distribution of Contomastix vacariensis, an endemic lizard from southern Brazil. We used a single‐season occupancy model in a Bayesian framework to estimate the occupancy probability of the species in 69 sites with different distances from silviculture areas. Our data showed a low probability of occupancy of C. vacariensis within a distance smaller than 1000 m from silviculture areas, while detection probability was negatively influenced by wind speed. This is the first work to demonstrate a gradual negative effect of exotic silviculture in lizards, which may be more intense inside planted areas and decrease as the distance from the exotic plantation increases. Such results may help delimit the size of conservation areas and management of exotic silviculture species within these areas. Studies with similar methods, considering the distance from the effects of environmental impacts, can be a helpful tool to make predictions based on the projected growth of silviculture in natural areas supporting threatened species.
Canine reference genome accuracy impacts variant calling: Lessons learned from investigating embryonic lethal variants
Authors: Kinsey Nathan A. , Belanger Janelle M. ,   Dog Biomedical Variant Database Consortium, Oberbauer Anita M. 
Published: July 2022

AbstractDeficient homozygosity of a variant maintained in a population suggests that the variant may be embryonic lethal. We examined whole genome sequence data from 675 canids to investigate for variants with missing homozygosity and high predicted impact. Our analysis identified 45 variants, in 32 genes. However, further scrutiny of the sequence reads revealed that all but one of these variants were artifacts of the variant calling process when using CanFam3.1, a widely utilized canine reference genome. We demonstrate that the use of multiple, newer reference genomes could reduce artifacts and lead to more accurate variant identification.
Intrauterine infusion of low levels of interferon‐tau on day‐8 post‐estrus stimulates the bovine endometrium to secrete apolipoprotein‐A1: A possible implication for early embryo tolerance
Authors: Rashid Mohammad B. , Marey Mohamed A. , Fukuda Kenji , Haneda Shingo , Kusama Kazuya , Shimada Masayuki , Imakawa Kazuhiko , Miyamoto Akio 
Published: July 2022

AbstractWe previously reported that interferon‐tau (IFNT), derived from day‐7 blastocyst, generates anti‐inflammatory responses in bovine endometrial epithelial cells (BEECs) in vitro. However, the real in vivo impact of early embryo‐derived IFNT on the uterine proteomic profile is mostly unknown. This study aimed to investigate proteomic changes of uterine flush (UF) when infused with a low physiological level of IFNT without embryo on day‐8 post‐estrus and its possible impact on the uterine immunological microenvironment. First, a fresh medium was infused into the uterine lumen on day‐6, from which UF was obtained 24 h later, and this procedure was repeated on day‐7 (control UF). On day‐8, this procedure was done with a medium containing recombinant bovine IFNT (100 pg/ml) (IFNT‐supplemented UF). Control and IFNT‐supplemented UF were tested for immune responses in peripheral blood mononuclear cells (PBMCs). Real‐time PCR results revealed that IFNT‐supplemented UF downregulated pro‐inflammatory cytokines (TNFA, IL1B) and upregulated anti‐inflammatory cytokine (TGFB1) and PTGES in PBMCs. Through 2‐D PAGE, followed by TOF/TOF mass spectrometer, apolipoprotein‐A1 (Apo‐A1) protein was identified in the IFNT‐supplemented UF, which was confirmed by ELISA analysis. Proteomic analysis revealed again that the in vitro stimulation of BEECs by IFNT upregulated Apo‐A1 expression. Further, stimulation of PBMCs with recombinant bovine Apo‐A1 downregulated TNFA and NFKB and upregulated TGFB1 and PTGES in PBMCs. Altogether, our results suggest that minute amounts of IFNT alone, normally secreted from bovine blastocyst, stimulate Apo‐A1 secretion from the endometrial epithelium in the absence of embryo that initiates an anti‐inflammatory environment, which could pave the way for the acceptance of early embryo in the uterus.
Acute corneal allograft rejection following SARS‐CoV‐2 vaccination–A systematic review
Authors: Moura‐Coelho Nuno , Cunha João Paulo , Papa‐Vettorazzi Renato , Gris Óscar , Güell José Luis 
Published: July 2022

AbstractAll documented cases of acute corneal allograft rejection following SARS‐CoV‐2 vaccination were examined, to characterize possible risk factors and graft outcomes. Comprehensive search (4 electronic databases: PubMed, CENTRAL, ClinicalTrials.gov, Google Scholar, plus manual search in articles' reference lists) until March 1st 2022 to identify studies reporting acute corneal allograft rejection following SARS‐CoV‐2 vaccination; study protocol was developed in line with PRISMA statement. We analysed demographics, allograft type, rejection prophylaxis regime at the time of vaccination, transplantation‐to‐vaccination time (G‐Vt), vaccination‐to‐immune reaction onset time (V‐Rt), management, best‐corrected visual acuity before and after rejection, and graft survival. Of 169 titles/abstracts screened, 16 studies (n = 36 eyes) met the inclusion criteria. Fourteen eyes (38.9%) had received >1 graft, and 11.1% of cases had history of immune reactions; 52.9% of cases occurred after the first dose. Median (P25‐P75) G‐Vt was 48 (10–78) months; median V‐Rt was 9 (7–14) days. In eyes with resolved rejection, median time‐to‐resolution was 3 (1–4) weeks. Four eyes (11.1%) had partial resolution of corneal decompensation, and 5 grafts (13.9%) failed. Acute corneal allograft rejection after SARS‐CoV‐2 vaccination is a rare event, but may occur any time post‐keratoplasty. Early recognition and prompt, aggressive treatment is warranted to optimize vision and graft survival. Well‐known risk factors for rejection may be confounding factors, including the high proportion of cases with a history of previous grafts and the rejection prophylaxis regimes at the time of vaccination. Increasing immunosuppressants in the peri‐vaccination period may decrease the risk of immune reactions, especially in high‐risk cases.
An integrated perspective on individual and team resilience: Moving from multilevel structure to cross‐level effects
Authors: Fisher David M. , LeNoble Chelsea A. , Vanhove Adam J. 
Published: July 2022

AbstractWe address the interrelatedness of resilience across levels by proposing a series of cross‐level effects between individual and team resilience. First, we present a homologous model of resilience including four core components that transcend levels of analysis: (1) the occurrence of adversity, (2) the capacity for resilience (3) the enactment of resilience, and (4) the demonstration of resilience. Second, building on a multilevel perspective and existing theory (e.g., conservation of resources and role theory), we present five foundational principles for understanding cross‐level resilience effects: (1) resilience components are interrelated across levels; (2) resilience capacity resources are finite and subject to depletion; (3) resources can be derived from and applied to individual or team levels; (4) effectively enacting resilience requires alignment between resources and situational demands; and (5) resilience processes can conflict across levels. Finally, we present a series of propositions that elucidate potential cross‐level effects between components of individual and team resilience, including those with positive, null, and negative consequences. This work advances the resilience literature by offering an integrated, cross‐level perspective concerning the ways in which individual and team resilience are likely interrelated.
Risk of dementia in patients with inflammatory bowel disease: a Danish population‐based study
Authors: Rønnow Sand Jakob , Troelsen Frederikke Schønfeldt , Horváth‐Puhó Erzsébet , Henderson Victor W. , Sørensen Henrik Toft , Erichsen Rune 
Published: July 2022

SummaryBackgroundInflammatory bowel disease (IBD) may be associated with increased dementia risk, but the literature is conflicting.AimTo investigate dementia risk in patients with IBD.MethodsWe conducted a nationwide population‐based cohort study in Denmark (1977–2018) including all patients with incident IBD matched with up to 10 general population comparators without IBD by sex, year of birth and region of residence. We calculated cumulative incidence proportions (CIPs) of dementia treating death as a competing risk, and adjusted hazard ratios (HRs) comparing IBD patients with matched comparisons. In a nested case–control analysis, we investigated the impact of IBD severity, steroid use, colorectal and small bowel surgery, and healthcare system contacts on dementia risk.ResultsOf 88,985 patients with IBD (69.6% with ulcerative colitis [UC], 30.4% with Crohn's disease [CD]) and 884,108 comparisons, 2076 patients (78.1% with UC) and 23,011 comparisons (76.6% UC comparisons) developed dementia. The 40‐year CIP of all‐cause dementia was 7.2% for UC patients and 5.8% for CD patients. UC patients had a slightly increased HR of all‐cause dementia (HR = 1.07 [95% confidence interval (CI): 1.01;1.12]) and Alzheimer's disease (HR = 1.10 [95% CI: 1.01–1.19]). CD patients had an increased HR of all‐cause dementia (HR = 1.15 [95% CI: 1.05–1.27]) and frontotemporal dementia (HR = 2.70 [95% CI: 1.44–5.05]). Dementia in IBD patients was associated with frequent healthcare system contacts.ConclusionsUC and CD are associated with slightly increased all‐cause dementia risk, particularly frontotemporal dementia in CD patients. Frequent healthcare system contacts by patients with IBD and detection bias may play a role in the association.
An in silico–in vitro pipeline for drug cardiotoxicity screening identifies ionic pro‐arrhythmia mechanisms
Authors: Clark Alexander P. , Wei Siyu , Kalola Darshan , Krogh‐Madsen Trine , Christini David J. 
Published: July 2022

Background and PurposeBefore advancing to clinical trials, new drugs are screened for their pro‐arrhythmic potential using a method that is overly conservative and provides limited mechanistic insight. The shortcomings of this approach can lead to the mis‐classification of beneficial drugs as pro‐arrhythmic.Experimental ApproachAn in silico–in vitro pipeline was developed to circumvent these shortcomings. A computational human induced pluripotent stem cell‐derived cardiomyocyte (iPSC‐CM) model was used as part of a genetic algorithm to design experiments, specifically electrophysiological voltage clamp (VC) protocols, to identify which of several cardiac ion channels were blocked during in vitro drug studies. Such VC data, along with dynamically clamped action potentials (AP), were acquired from iPSC‐CMs before and after treatment with a control solution or a low‐ (verapamil), intermediate‐ (cisapride or quinine) or high‐risk (quinidine) drug.Key ResultsSignificant AP prolongation (a pro‐arrhythmia marker) was seen in response to quinidine and quinine. The VC protocol identified block of IKr (a source of arrhythmias) by all strong IKr blockers, including cisapride, quinidine and quinine. The protocol also detected block of ICaL by verapamil and Ito by quinidine. Further demonstrating the power of the approach, the VC data uncovered a previously unidentified If block by quinine, which was confirmed with experiments using a HEK‐293 expression system and automated patch‐clamp.Conclusion and ImplicationsWe developed an in silico–in vitro pipeline that simultaneously identifies pro‐arrhythmia risk and mechanism of ion channel‐blocking drugs. The approach offers a new tool for evaluating cardiotoxicity during preclinical drug screening.
Scientific evaluation of alleged findings in HPV vaccines: Molecular mimicry and mouse models of vaccine‐induced disease
Authors: Matsumura Noriomi , Tsunoda Ikuo 
Published: July 2022

AbstractCervical cancer is caused by infections of the human papillomavirus (HPV), which can be prevented by vaccinations. In Japan, although about 3000 people die of cervical cancer annually, the HPV vaccination rate has remained extremely low in the eligible population since many Japanese have been concerned that “diverse symptoms,” such as chronic pain, movement disorders, and cognitive impairment, may occur as adverse reactions after HPV vaccination. The concern has been raised by media coverage of the ongoing HPV vaccine lawsuits, in which the plaintiffs complained of their symptoms caused by HPV vaccination. The claims have been based on the alleged pathogenic findings in research articles on HPV vaccines, summarized in the document prepared by the plaintiffs' attorneys. We critically evaluated these articles, in which the authors proposed the following findings/hypothesis: (i) molecular mimicry between HPV L1 and human proteins leads to the production of cross‐reactive antibodies; and (ii) HPV vaccine injection in mice causes damage in the brain, a mouse model for HPV vaccine associated neuro‐immunopathic syndrome (HANS). We found that these hypotheses were based mainly on the findings from a few research groups and that all the articles had flaws in the method, result, or discussion sections. Our current evaluation should help better understand the validity of the findings, which have been often misunderstood as the truth by the general public. We propose to accumulate high‐quality data on potential adverse events following HPV vaccination and to continue critically evaluating them.
Establishing the relationship between familial dysbetalipoproteinemia and genetic variants in theAPOEgene
Authors: Heidemann Britt E. , Koopal Charlotte , Baass Alexis , Defesche Joep C. , Zuurbier Linda , Mulder Monique T. , Roeters van Lennep Jeanine E. , Riksen Niels P. , Boot Christopher , Marais A. David , Visseren Frank L. J. 
Published: July 2022

AbstractFamilial Dysbetalipoproteinemia (FD) is the second most common monogenic dyslipidemia and is associated with a very high cardiovascular risk due to cholesterol‐enriched remnant lipoproteins. FD is usually caused by a recessively inherited variant in theAPOEgene (ε2ε2), but variants with dominant inheritance have also been described. The typical dysbetalipoproteinemia phenotype has a delayed onset and requires a metabolic hit. Therefore, the diagnosis of FD should be made by demonstrating both the genotype and dysbetalipoproteinemia phenotype. Next Generation Sequencing is becoming more widely available and can reveal variants in theAPOEgene for which the relation with FD is unknown or uncertain. In this article, two approaches are presented to ascertain the relationship of a new variant in theAPOEgene with FD. The comprehensive approach consists of determining the pathogenicity of the variant and its causal relationship with FD by confirming a dysbetalipoproteinemia phenotype, and performingin vitrofunctional tests and, optionally,in vivopostprandial clearance studies. When this is not feasible, a second, pragmatic approach within reach of clinical practice can be followed for individual patients to make decisions on treatment, follow‐up, and family counseling.