bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promoting sleep and other simple, non-pharmacological interventions for preventing and treating ICU Delirium: case report
Authors: Chou Shinn-Te , Pogach Melanie , Rock Laura K. 
Published: February 2022

Abstract
Delirium is common among critically ill patients and it prolongs the length of ICU and hospital stays and is associated with worse outcomes, including cognitive impairment and increased mortality. No medications have been shown to have a consistent therapeutic benefit. Delirium is a form of brain dysfunction characterized by the acute onset of fluctuating mental status, inattention, disorganized thinking, and altered level of consciousness. These features are also seen in states of acute sleep deprivation. It is believed that the state of delirium contributes to disrupted sleep just as sleep deprivation is considered a modifiable risk factor for delirium. Improving sleep conditions and other nonpharmacologic interventions to promote sleep may be an underused approach to preventing and treating delirium in critical illness.
Management of Complications After Skin Surgery Relevant for Melanoma in the Trunk and Extremities Under the COVID-19 Pandemic: A Case Series Report
Authors: Huang Yinglai , Carlsson Lena , Jogeland Karin , Samuelsson Marianne , Larsson Lars , Jonsborg Catarina 
Published: February 2022

Abstract
Background: Patients with melanoma have been found to be at greater risk of adverse outcomes including mortality after contacting COVID-19. Management of postsurgical complications presented additional challenges by potentially increasing exposure to COVID-19 through repeated inpatient admissions to hospital during the pandemic. We report four cases for which skin flaps, lymph ligation and split-thickness skin graft (STSG) were successfully used in the treatment of complications in the trunk and extremities after wide local excision (WLE). This study details the operative experience in management of postsurgical complications for melanoma in the trunk and extremities during a 6-month period at the height of the COVID-19 pandemic Case presentation: We present 4 cases detailing management of complications that occurred after wide local excisions performed for melanoma during Feb. to Oct.-2020. Case 1: a 90-year-old man who experienced wound dehiscence and necrosis on the shoulder after non- radical excision for an aggressive melanoma, underwent the side-to-side closure after ellipse formed WLE with modified tangent-to-circle method. Case 2: an 80-year-old man who had undergone excision for melanoma in his left upper arm, histopathology did not show radically. Two weeks after the excision, he underwent a WLE and direct reconstruction with double rotation skin flap. Case 3: a 55-year-old man that experienced a large wound dehiscence on his back due to WLE. He underwent an advanced double skin flap operation. Case 4: a 36-year-old woman who had a lymphorrhea and graft necrosis after WLE and STSG on the right lower leg. A combination of micro lymph ligation and re- STSG was performed. One month after the operation, all wounds had healed. There was no clinical evidence of tumor recurrence after eight months post procedure. Conclusions: Severe complications (e.g., large wound dehiscence, necrosis or lymphorrhea) following wide local excision of melanoma are infrequent but must be swiftly and appropriately managed, especially during the COVID-19 pandemic to decrease the likelihood of COVID-19 infection and impaired oncology outcomes from delaying systemic cancer therapy due to the complications in primary interventions.
Glycogen storage disease Ia complicated with multiple hepatic adenomas: a case report and literature review
Authors: Tian Sufang , zhang Wanyu , Fan Wei , Zhang Zhonglin 
Published: February 2022

Abstract
Background: Glycogen storage diseases (GSDs) are a rare group of autosomal recessive genetic disease. The pathogenesis of GSD is derangement of carbohydrate metabolism and results in abundant glycogen accumulation within tissues. Clinically, patients suffering from GSD are characterized with growth retardation, puberty delay, hyperuricemia, hypoglycemia and hepatomegaly, occasionally, complicated with hepatic adenoma.Case presentation: A 29-year-old man was admitted to our hospital with enlarged liver masses after a 2-year-long follow-up. Physical examinations showed he was 160cm in height, 50kg in weight and many tophi in his joints. Laboratory examinations showed hypoglycemia, elevated uric acid and free fatty acids, but negative tumor markers. After reviewing his clinical history, GSD Ia was suspected for the underlying disease and complicated with multiple hepatocellular neoplasm. The precise diagnosis was made finally by combining pathology examination, biochemical assays and whole exome sequencing (WES).Conclusions: The present case would be conductive for general pathologists to recognize the clinicopathological features of GSD and prompt diagnosis. On patients’ side, it will be vital for their timely follow-up and management.
Exploring intervention components grounded in critical race theory, harm reduction, and self-determination theory: A qualitative study with Black and Latino persons living with HIV in the United States
Authors: Cluesman Sabrina , Gwadz Marya 
Published: February 2022

Abstract
Background
. The persistence of racial/ethnic disparities in the United States in rates of engagement along the HIV care continuum signals the need for novel approaches. We recently described a new integrated conceptual model (ICM) that combines critical race theory, harm reduction, and self-determination theory. This ICM guided the development of six behavioral intervention components tested in optimization trial (Core component, Component A: motivational interviewing sessions, Component B: pre-adherence skill building, Component C: peer mentorship, Component D: focused support groups, Component E: navigation). The present qualitative exploratory study describes participants’ perspectives on the components’ acceptability, feasibility, and impact.
Methods
. Participants were African American/Black and Latino PLWH poorly engaged in HIV care and with non-suppressed HIV viral load in New York City. From a larger optimization trial (N = 512), we randomly selected 46 participants for in-depth semi-structured interviews. Interviews were audio-recorded and transcribed verbatim, and data were analyzed using directed content analysis. Structured data on components’ acceptability and feasibility were collected.
Results
. On average, participants were 49 years old (SD = 9) and had lived with HIV for 19 years (SD = 7). Most were male (78%) and African American/Black (76%). Participants reported a constellation of serious mainly social and structural challenges to HIV management including chronic poverty, unstable housing, and stigma. Components were found acceptable (> 70% rated them as quite a bit to very helpful). Feasibility was high: attendance rates for each component was > 80%. For all components, a non-judgmental, pressure-free, and structurally and culturally salient approach was seen as vital and described as lacking in most medical/social service settings. Prominent aspects of components, consistent with the ICM, included establishing trust (core); developing intrinsic motivation and self-reflection (Component A); learning/practicing adherence strategies and habits (Component B); reducing social isolation via peer role models (Component C); reflecting on salient goals and challenges with peers without stigma (Component D); and circumventing structural barriers to HIV management, including related to systemic racism (Component E).
Conclusions
. The ICM has potential to improve the acceptability and feasibility of interventions and services for AABL-PLWH, key underpinnings of intervention/treatment effectiveness. Future study of the ICM is warranted to address racial/ethnic health disparities.
Spatial Phase Synchronisation of Pistachio Alternate Bearing
Authors: Sakai Kenshi , Brown Patrick , Rosenstock Todd , Upadhyaya Shrini , Hastings Alan 
Published: February 2022

Abstract
Collective dynamics of chaotic oscillators has attracted much attention in many fields even including agriculture and forestry. Alternate bearing of tree crops is a phenomenon in which a year of heavy yield is followed by a light yield. This phenomenon has been modelled using a tent map known as a resource budget model (RBM). We applied in-phase/out-of-pahse analysis to yield data of a 9,562 pistachio plants population and revealed phase transitions and mode locking in the orchard. Using a developed network model consisting of diffusively coupled chaotic oscillators (RBMs) on which common noise imposed, we theoretically confirm the phase transitions mode locking and 1/3 power-law scaling in the yield data. Here, we demonstrate how three essential factors, i.e. common noise, direct coupling, and cropping coefficient gradient, explain the spatial synchrony of the orchard.
Research Advancements on Fluorinated and Non-Fluorinated 4-
Phenyl(thio)ureido-Substituted 2,2-Dimethylchromans Acting as Inhibitors
of Insulin Release and Smooth Muscle Relaxants
Authors: Pirotte Bernard , Florence Xavier , Goffin Eric , Leleux Fabienne , Lebrun Philippe 
Published: February 2022

Aims:
The present study aimed at characterizing the impact of the presence or absence of
fluorine atoms on the phenyl and benzopyran rings of 4-phenyl(thio)ureido-substituted 2,2-
dimethylchromans on their ability to inhibit insulin release from pancreatic β-cells or to relax vascular
smooth muscle cells.

Methods:
Most compounds were found to inhibit insulin secretion and to provoke a marked
myorelaxant activity.

Results:
The lack of a fluorine or chlorine atom at the 6-position of the 2,2-dimethylchroman core
structure reduced the inhibitory activity on the pancreatic endocrine tissue. One of the most active
compounds on both tissues, compound 11h (BPDZ 678), was selected for further pharmacological
investigations.

Conclusion:
The biological data suggested that 11h mainly expressed the profile of a KATP channel
opener on pancreatic β-cells, although a calcium entry blockade effect was also observed. On vascular
smooth muscle cells, 11h behaved as a calcium entry blocker.
Hypomyelination with Atrophy of Basal Ganglia and Cerebellum (HABC)
Due to UFM1 Mutation in Roma Patients - Severe Early Encephalopathy
with Stridor and Severe Hearing and Visual Impairment. A Single
Center Experience
Authors: Ivanov Ivan , Pacheva Iliyana , Yordanova Ralitsa , Sotkova Iglika , Galabova Fani , Gaberova Katerina , Panova Margarita , Gheneva Ina , Tsvetanova Tsvetelina , Noneva Katerina , Dimitrova Diana , Markov Stoyan , Sapundzhiev Nikolay , Bichev Stoyan , Savov Alexey 
Published: February 2022

Background:
Hypomyelination with atrophy of the basal ganglia and cerebellum (H-ABC)
is a neurodegenerative disease with neurodevelopmental delay, motor, and speech regression, pronounced
extrapyramidal syndrome, and sensory deficits due to TUBB4A mutation. In 2017, a severe
variant was described in 16 Roma infants due to mutation in UFM1.

Objective:
The objective of this study is to expand the clinical manifestations of H-ABC due to UFM1
mutation and suggest clues for clinical diagnosis.

Methodology:
Retrospective analysis of all 9 cases with H-ABC due to c.-273_-271delTCA mutation
in UFM1 treated during 2013-2020 in a Neuropediatric Ward in Plovdiv, Bulgaria.

Results:
Presentation is no later than 2 months with inspiratory stridor, impaired sucking, swallowing,
vision and hearing, and reduced active movements. By the age of 10 months, a monomorphic disease
was observed: microcephaly (6/9), malnutrition (5/9), muscle hypertonia (9/9) and axial hypotonia
(4/9), progressing to opisthotonus (6/9), dystonic posturing (5/9), nystagmoid ocular movements (6/9),
epileptic seizures (4/9), non-epileptic spells (3/9). Dysphagia (7/9), inspiratory stridor (9/9), dyspnea
(5/9), bradypnea (5/9), apnea (2/9) were major signs. Vision and hearing were never achieved or lost
by 4-8 mo. Neurodevelopment was absent or minimal with subsequent regression after 2-5 mo. Brain
imaging revealed cortical atrophy (7/9), atrophic ventricular dilatation (4/9), macrocisterna magna
(5/9), reduced myelination (6/6), corpus callosum atrophy (3/6) and abnormal putamen and caput nuclei
caudati. The age at death was between 8 and 18 mo.

Conclusion:
Roma patients with severe encephalopathy in early infancy with stridor, opisthotonus,
bradypnea, severe hearing and visual impairment should be tested for the Roma founder mutation of
H-ABC in UFM1.
Similarity Analysis of User Trajectories Based on Haversine Distance and Needleman Wunsch Algorithm
Authors: Jamhuri Mohammad , Irawan Mohammad Isa , Mukhlash Imam 
Published: February 2022

Abstract: In this paper, we discuss the similarity between two trajectories using the Needleman Wunsch algorithm. The calculation steps are interpolating the trajectory, calculating the distance between the trajectory coordinates, identifying the equivalent length, transforming trajectories into a sequence of alphabetic letters, aligning the sequences, and measuring the magnitude of the similarity based on the alignment results. The similarity obtained is compared directly to the length of the trajectories shared by the two lines. The calculation results show that the accuracy of the alignment method reaches more than 90%. Abstrak: Dalam tulisan ini dibahas cara perhitungan persentase kesamaan dari dua buah lintasan menggunakan algoritma Needleman Wunsch dan perhitungan secara manual berdasarkan irisan dari lintasan-lintasan tersebut. Pada perhitungan menggunakan algoritma Needleman Wunsch, tahapan-tahapan yang dilakukan adalah menginterpolasi lintasan, menghitung jarak antara titik-titik koordinat dari kedua lintasan, mengidentifikasi jarak yang ekivalen, mengubah lintasan menjadi sekuens huruf alfabet, menyejajarkan sekuens, dan menentukan besarnya kesamaan berdasarkan hasil penyejajaran. Kesamaan yang diperoleh dari metode penyejajaran dibandingkan secara langsung dengan panjang jalur yang dilalui bersama oleh kedua lintasan, hasil perhitungan menunjukkan bahwa akurasi metode penyejajaran mencapai lebih dari 90%.
Posters and Development: A Case Study of Cell Phone Posters in the Rural Congo
Authors: Cibangu Sylvain 
Published: February 2022

One of the benchmarks of the information age often forgotten is the proliferation of posters or billboards in and around workplaces, neighborhoods, airports, shopping centers, restaurants, theaters, libraries, schools, etc. More interestingly, through cell phones, posters are rapidly entering rural areas in developing countries. Although these posters come with specific messages and graphics – continually upgraded and tailored to people’s attention -- they hardly undergo scientific inquiry in circles concerned with information and communication technologies [ICTs]. The lack of attention raises questions on the role of information systems and related wireless devices being deployed in developing countries. The present paper aimed to canvass cell phone posters and unbundle the underlying practices and routines. As well as positioning posters at the center stage of ICT research, the present paper applied critical discourse analysis to inquire into ways in which development was represented or effected among populations in the rural Congo.
The paper determined that posters were not centered on local populations and their day-to-day struggles/needs, and that the information conveyed on posters was not geared toward the development of the world’s poorest. The paper crafted some paths for future work in ICT fields and cell phone bodies of work.
PENYELESAIAN HUKUM KEKERASAN DALAM RUMAH TANGGA SECARA NONLITIGASI DI DESA TANJUNG SETEKO KECAMATAN INDRALAYA KABUPATEN OGAN ILIR PROVINSI SUMATERA SELATAN
Authors: Ramadhan Muhammad Syahri 
Published: February 2022

Kekerasan yang terjadi dalam rumah tangga lebih banyak dialami perempuan yang di sini berkedudukan sebagai seorang istri atau anak yang menjadi korban, sedangkan pelakunya didominasi oleh laki-laki yang berkedudukan sebagai seorang suami atau anak. Kekerasan dalam rumah tangga dapat disebabkan oleh berbagai faktor, baik faktor internal maupun eksternal dalam lingkup rumah tangga. Faktor internal yang dapat memicu terjadinya kekerasan dalam rumah tangga antara lain, karakter pelaku kekerasan yang cenderung emosi, ketergantungan ekonomi, pihak ketiga dalam rumah tangga, keadaan ekonomi, dan komunikasi yang berjalan dengan tidak baik. Perubahan pola pikir dalam masyarakat khususnya perempuan saat ini sudah berubah, hal ini terbukti dengan semakin meningkatnya gugatan perceraian di Pengadilan. Perubahan pemikiran ini seakan-akan membentuk suatu pandangan bahwa perkawinan bukanlah hal yang sakral sehingga tidak perlu diperjuangkan keutuhannya jika telah ditemukan perbedaan. Padahal permasalahan kekerasan dalam rumah tangga ini dapat dilakukan dengan cara di luar pengadilan (nonlitigasi). Kegiatan Penyuluhan Hukum Penyelesaian Hukum Kekerasan Dalam Rumah Tangga Yang Dilakukan Suami Terhadap Istri Di Luar Pengadilan Di Desa Tanjung Setetko Kecamatan Indralaya Kabupaten Ogan Ilir Provinsi Sumatera Selatan ini diharapkan dapat memberikan pemahaman kepada masyarakat tentang tindakan – tindakan yang termasuk KDRT dan efek negatifnya. Selain itu diharapkan dengan adanya penyuluhan tersebut diharapkan masyarakat memahami bahwa Kekerasan Dalam Rumah Tangga (KDRT) dapat diseleseaikan terlebih dahulu melalui jalur non-litigasi atau di luar pengadilan.
Pelatihan Matematika Gasing Pada Materi Penjumlahan dan Perkalian Dua Digit Dengan Dua Digit untuk Siswa Kelas VI Sekolah Dasar Negeri
Authors: Aprijon Aprijon 
Published: February 2022

Matematika merupakan salah satu Mata Pelajaran yang sangat Penting sehingga banyak sekali metode yang muncul untuk membantu siswa dalam menguasai matematika. Salah satu metode tersebut adalah Metode Gasing. Untuk dapat menerapkan mtode tersebut maka dilakukan Pelatihan Gasing. Pelatihan matematika Gasing ini bertujuan untuk mengetahui pemahaman siswa terhadap penggunaan metode ini. Adapun yang menjadi fokus pelatihan adalah siswa kelas 6 Sekolah Dasar negeri 012 Kualu Tambang Kampar. Jumlah sampel yang diambil pada pelatihan ini adalah sebanyak 20 orang. Metode GASING ini menitikberatkan pada pokok bahasan penjumlahan dan perkalian dua digit pada siswa. Berdasarkan hasil pelatihan yang dilaksanakan dapat disimpulkan terdapat perbedaan rata‐ rata nilai posttest dengan Matematika Gasing sebesar 69,75 dan proses pembelajarannya secara konvensional sebesar 57,25 serta Uhitung = 64 dan Utabel = 70. Hal ini menunjukkan penggunaan metode ini sangat signifikan pengaruhnya terhadap siswa dalam memahami matematika.
PENGARUH PENGELOLAAN PENGADUAN TERHADAP KEPUASAN PESERTA DI PT. TASPEN (PERSERO) KANTOR CABANG PADANG
Authors: Azhari Tessa , Frinaldi Aldri 
Published: February 2022

Abstract
The purpose of this study was to analyze complaint management for participant / customer satisfaction at PT. Taspen (Persero) Padang Office. This research is quantitative with associative methods. The background of this research is that there werw still complaints management that had not been optimal. This research was conducted at PT. Taspen (Persero) Padang Office with a total population of 131,233 participants, consisting of active civil servants and retired civil servants. The sample in this study consisted of 100 respondents determined by Slovin formula. The data of this study were collected through questionnaires with Likert scale measurements. The data of this study were analyzed by the Simple Regression test. The results of this study proved that there is a complaint management variable on the satisfaction of participants/customers at PT. Taspen (Persero) Padang Office.
Keywords: Complaint Management, Participant/ Customer Satisfaction
STRATEGI PEMERINTAH KOTA PARIAMAN DALAM PENGEMBANGAN SENTRA INDUSTRI KECIL MENENGAH
Authors: Anshari Jumadil , Khaidir Afriva 
Published: February 2022

Abstract
This study aims to determine the strategy of the City Government in the Development of Small and Medium Industry Centers Case Study in Kampung Perak, Kota Pariaman. This research was carried out because it saw the trading activities of the silver village which were still underdeveloped and were lacking in marketing and human resources. This research is a qualitative research with a descriptive approach. The informants selected in this study used purposive sampling and incidental sampling techniques. Data collection techniques with observation, documentation, and in-depth interviews. As well as data validity testing using source triangulation and method triangulation. Based on the results of this study indicate that in Based on the results of this study indicate that in the strategy of the City Government in the Development of Small and Medium Industry Centers Case Study in Kampung Perak, Kota Pariaman which is still undeveloped due to the lack of knowledge of traders in the silver village in the field of marketing and human Resources .

Keywords: Strategy, Development, UMKM, Kampung Perak Ringan
IMPLEMENTASI PERATURAN DAERAH KOTA BUKITTINGGI NOMOR 2 TAHUN 2015 TENTANG PENCEGAHAN DAN PENANGGULANGAN BAHAYA KEBAKARAN
Authors: Aprina Yelni , Yusran Rahmadani 
Published: February 2022

ABSTRAK
The purpose of this research was to determine the implementation of the Regional Regulation of Bukittinggi cities Number 2 of 2015 about Fire hazard Prevention and countermeasures. This research is a qualitative research and uses descriptive methods. The research informants were determined using purposive sampling techniques. including the head of the treatise section and the session of the Bukittinggi Cities DPRD, Head of sub-division Documentation and legal counseling of Bukittinggi cities, The head of the prevention section and the head of the operational section of the fire department, Head of K3L PLN of Bukittinggi cities, fire victim and society of Bukittinggi cities. Data collection techniques carried out by observation, interview and study documentation. To test the validity of the data using source triangulation techniques. The results showed that the implementation of local regulations have not been implemented optimally, there are still some aspects that still need attention such as aspects of the target group, aspects of the desired degree of change, resources involved, characteristics of the ruling institutions as well as compliance and responsiveness. There are supporting factors in the implementation of regional regulations such as the socialization carried out by related parties, the implementation of the Regional Regulation is also supported by the provision of training and education to officers so that they have the ability and skills in their fields. Resources and lack of commitment in implementing local regulations. So that efforts are needed by the government in implementing policies.

keywords: Implementation of policies, prevention and mitigation of fire hazards,
regional regulation of Bukittinggi cities