bluuebunny/crossref_metadata_2025_split huggingface dataset:
Active monitoring of adverse reactions following COVID-19 and other vaccinations: a feasibility study as part of the CoVaKo project
Authors: Zeschick Nikoletta , Warkentin Lisette , Kühlein Thomas , Steininger Philipp , Überla Klaus , Hueber Susann , Sebastião Maria 
Published: July 2022

Abstract
Background
The Corona-Vakzin-Konsortium project (CoVaKo) analyses the efficacy and safety of COVID-19 vaccines in a real-world setting, as well as breakthrough infections in Bavaria, Germany. A subproject of CoVaKo aims to identify adverse reactions of the COVID-19 vaccine and compare these to adverse reactions of other vaccines in an online survey. In a preceding feasibility study, the study materials were tested for comprehensibility, visual design, and motivation to participate, as well as for their ability to be implemented and carried out in primary care practices and vaccination centres.

Methods
We used a mixed-methods research design. First, three focus groups consisting of general population participants were organised to evaluate the study materials and survey. Second, a test roll-out was conducted in vaccination centres and primary care practices that involved implementing and quantitatively evaluating the online survey. Third, interviews were conducted with participating general practitioners and heads of vaccination centres four weeks after the test roll-out.

Results
Parts of the information and registration form proved incomprehensible, specifically regarding the recruitment material and/or online survey. For example, headings were misleading given that, relative to other vaccinations, the COVID-19 vaccination was overemphasised in the title. Participants requested additional information regarding the procedure and completion time. Within 31 days, 2199 participants, who received either a COVID-19 vaccination (99%) or at least one of the control vaccinations (1%), registered for the study. Participants (strongly) agreed that the registration process was easy to understand, that the completion time was reasonable, and that the technical setup was straightforward. Physicians and heads of the vaccination centres perceived the study as easy to integrate into their workflow. The majority expressed willingness to participate in the main study.

Conclusions
Our study indicated that identifying and documenting adverse reactions following vaccinations using an online survey is feasible. Testing materials and surveys provided valuable insight, enabling subsequent improvements. Participation from health professionals proved essential in ensuring the practicality of procedures. Lastly, adapting the study’s organisation to external fluctuating structures and requirements confirmed necessary for a successful implementation, especially due to dynamic changes in the nation’s COVID-19 vaccination strategies.

Trial registration
The trial was retrospectively registered at the “Deutsches Register Klinischer Studien” (DRKS-ID: DRKS00025881) on Oct 14, 2021.
Systematic review of the characteristics of school-based feasibility cluster randomised trials of interventions for improving the health of pupils in the UK
Authors: Parker Kitty , Eddy Saskia , Nunns Michael , Xiao ZhiMin , Ford Tamsin , Eldridge Sandra , Ukoumunne Obioha C. 
Published: July 2022

Abstract
Background
The last 20 years have seen a marked increase in the use of cluster randomised trials (CRTs) in schools to evaluate interventions for improving pupil health outcomes. Schools have limited resources and participating in full-scale trials can be challenging and costly, given their main purpose is education. Feasibility studies can be used to identify challenges with implementing interventions and delivering trials. This systematic review summarises methodological characteristics and objectives of school-based cluster randomised feasibility studies in the United Kingdom (UK).

Methods
We systematically searched MEDLINE from inception to 31 December 2020. Eligible papers were school-based feasibility CRTs that included health outcomes measured on pupils.

Results
Of 3285 articles identified, 24 were included. School-based feasibility CRTs have been increasingly used in the UK since the first publication in 2008. Five (21%) studies provided justification for the use of the CRT design. Three (13%) studies provided details of a formal sample size calculation, with only one of these allowing for clustering. The median (IQR; range) recruited sample size was 7.5 (4.5 to 9; 2 to 37) schools and 274 (179 to 557; 29 to 1567) pupils. The most common feasibility objectives were to estimate the potential effectiveness of the intervention (n = 17; 71%), assess acceptability of the intervention (n = 16; 67%), and estimate the recruitment/retention rates (n = 15; 63%). Only one study was used to assess whether cluster randomisation was appropriate, and none of the studies that randomised clusters before recruiting pupils assessed the possibility of recruitment bias. Besides potential effectiveness, cost-effectiveness, and the intra-cluster correlation coefficient, no studies quantified the precision of the feasibility parameter estimates.

Conclusions
Feasibility CRTs are increasingly used in schools prior to definitive trials of interventions for improving health in pupils. The average sample size of studies included in this review would be large enough to estimate pupil-level feasibility parameters (e.g., percentage followed up) with reasonable precision. The review highlights the need for clearer sample size justification and better reporting of the precision with which feasibility parameters are estimated. Better use could be made of feasibility CRTs to assess challenges that are specific to the cluster design.

Trial registration
PROSPERO: CRD42020218993.
The inconsistency of documentation: a study of online C standard library documents
Authors: Li Ruishi , Yang Yunfei , Liu Jinghua , Hu Peiwei , Meng Guozhu 
Published: July 2022

AbstractThe C standard libraries are basic function libraries standardized by the C language. Programmers usually refer to their API documentation provided by third-party websites. Unfortunately, these documents are not necessarily complete or accurate, especially for constraint sentences of API usage, which are called Security Specifications (SSs). SS issues can prevent programmers from following obligatory constraints, which results in API misuse vulnerabilities. Previous work studying SS issues could only find certain types of inaccurate SSs through checking the compliance between API usage and existing SSs. Therefore, we propose a novel approach SSeeker for quickly discovering missing and inaccurate SSs through the inconsistency of semantically similar SSs. More specifically, SSeeker first completes broken sentences and discovers SSs from them by judging their constraint sentiment. Then SSeeker puts semantically similar SSs from different sources into a group, which can be used to discover missing or inaccurate SSs. With the help of SSeeker, we investigated 4 popular online third-party C standard library documents, studied their conformity with the C99 standard, analyzed their APIs and SSs, and discovered 92 prototype issues, 15 web page issues, and 96 SS issues.
Frequency changes during the propagation of a light beam
Authors: Emile Olivier , Emile Janine 
Published: July 2022

Abstract
The energy and therefore the frequency of electromagnetic fields are quantities which are generally considered to be conserved in free space propagation. However, we observe here a frequency varying optical wave in free space propagation. The light comes from an Arago spot. Its frequency changes due to the rotational Doppler effect. More precisely, the light diffracted by a two-dimensional asymmetric object carries orbital angular momentum that varies with distance. As the object rotates, the frequency of the diffracted light experiences different rotational Doppler shifts along propagation. It varies in a discrete quantized way as it propagates. It can be adjusted, without violation of the conservation of energy. Since this phenomenon is deeply rooted in the diffraction process, it sheds some new light on this still open issue.
Palmar Striated Xanthomas in Clinical Practice
Authors: Roy Nathalie , Gaudet Daniel , Brisson Diane 
Published: July 2022

AbstractContextPalmar striated xanthomas (PSX) are macular subcutaneous lesions conferring a yellow-to-orange coloration of palmar and finger creases that characterize dysbetalipoproteinemia, a disease associated with sustained plasma accumulation of triglyceride-rich lipoprotein remnants. Although remnants accumulation may occur in any condition interfering with triglyceride-rich lipoprotein hydrolysis or clearance, the presence of PSX has not been systematically assessed across the spectrum of lipid disorders potentially associated with sustained or recurrent remnants accumulation.ObjectiveThe aim of this study was to assess the occurrence of (PSX) in a wide spectrum of lipid disorders ranging from very severe hypercholesterolemia (homozygous familial hypercholesterolemia) to very severe hypertriglyceridemia (chylomicronemia).MethodsThis study involved 3382 dyslipidemic White adult patients (1856 men and 1526 women) seen at the Chicoutimi Hospital Lipid Clinic (Quebec, Canada), covering a wide range of lipid disorders, from severe hypertriglyceridemia to severe hypercholesterolemia. Categorical variables were compared using the Pearson χ 2 statistic, whereas univariate analysis of variance or nonparametric Kruskal-Wallis was used for continuous variables.ResultsA total of 5.1% (173/3382) of the studied patients presented PSX, a majority of them (67.1%) being women. PSX were observed in 18.8% of patients with dysbetalipoproteinemia and also among 14.1% of hypertriglyceridemic patients with partial lipoprotein lipase deficiency, 3.7% of patients with chylomicronemia, and in all those with homozygous familial hypercholesterolemia. Overall, 10.7% of patients with PSX did not meet dysbetalipoproteinemia diagnosis criteria.ConclusionAccording to our study, the PSX prevalence estimate among patients without dysbetalipoproteinemia would be around 10% and they could be observed in a wide spectrum of lipid disorders associated with recurrent or sustained remnant lipoprotein accumulation.
Temporomandibular joint disorders prevalence and awareness of appropriate clinical practices, among Al-Madinah community: A prospective cross sectional study
Authors: Alolayan Albraa , Alsayed Shayma S. , Salamah Ruwaa M. , Ali Khadija M. , Alsousi Mashael , Elsayed Shadia 
Published: July 2022

Background: Painful temporomandibular joint disorders (TMDs) are of musculoskeletal origin and are considered the most common cause of non-odontogenic pain in the orofacial region. The purpose of this study was to investigate the prevalence and awareness of temporomandibular joint (TMJ) disorders in Almadinah Almunawwarah community. Methods: A prospective observational cross-sectional study with convenience sampling was conducted. A translated Arabic version of Fonseca's questionnaire was employed. The questionnaire asked about the participant's personal information, if they thought they had TMDs, and who to visit for therapy if necessary. These were followed by 10 items from Fonseca's questionnaire, each with a three-point scale. Results: The questionnaire was completed by 598 people. Females made up 57.1% of the participants. TMDs were present in 61% of the population, with varying degrees of severity. Males (44.3%) were less affected than females (55.7%). The difference, however, was not statistically significant (P = 0.354). Out of the 61% TMDs Positive patients, 74.1% had mild TMDs symptoms, while 20.8% and 5.1%, respectively, had moderate and severe TMDs symptoms (P = 0.05). The severity of the symptoms was unaffected by demographic data (P > 0.05). Only 40% seek care, with 64.6% selecting for a dentist and 24.6% preferring for an orthopaedic specialist (P= 0.008). Conclusions: Participants from Al-Madinah had a greater prevalence of mild TMDs. The majority of the participants had no idea who to go to for treatment. The findings of this study highlight the importance of educational activities to enhance public awareness
Robustness of the aging effect of smiling against vertical facial orientation
Authors: Yoshimura Naoto , Yonemitsu Fumiya , Sasaki Kyoshiro , Yamada Yuki 
Published: July 2022

Background: Previous studies have shown that the association between smiling and youth is a misconception; smiling faces have been estimated to be older than neutral faces. Previous studies have indicated that this aging effect of smiling (AES) is due to eye wrinkles caused by the facial action of smiling. However, whether holistic processing for facial expressions is involved in AES has not been investigated. The present study aimed to clarify these issues. Methods: Participants were recruited to participate in an online experiment that had a 3 (facial expression: smiling/neutral/surprised) × 2 (facial orientation: upright/inverted) mixed design. Participants were presented with an upright or inverted face for each expression (neutral, smiling, and surprised) and were asked to estimate the individual’s age. Results: In total, 104 participants were included in the analysis. The results show that smiling faces were estimated to be older than neutral faces, whereas there was no significant difference between upright and inverted faces. Conclusions: Our findings suggest that AES is not dependent on holistic processing.
Association between dermatoglyphic patterns and growth patterns of subjects with skeletal class I relation: A cross sectional study
Authors: Shashidhar Keerthan , M N Kuttappa , Nayak U S Krishna , D'Souza Neevan , Shetty Mahabalesh , Achalli Sonika 
Published: July 2022

Background: To assess the relationship between dermatoglyphic patterns and various growth patterns of the mandible. Methods: Patients with Class I Skeletal relation were selected after clinical diagnosis followed by digitally tracing the cephalogram. The patients were subdivided into three groups of mandibular divergence patterns ie Average, Horizontal and Vertical. 90 samples ie 30 in each group were selected for the study. The fingerprints of all the selected subjects were then extracted digitally and analysed for the most dominant pattern in each hand. Results: For the left hand, there was a statistically significant (P<0.05) association between fingerprint pattern and growth pattern when Horizontal growers were compared to Average and Vertical Growers. For the right hand, there was a statistically significant (P<0.05) association between fingerprint pattern and growth pattern when Horizontal growers were compared to Average Growers. A significant association (P<0.05) between fingerprint pattern and growth pattern was also found when average growers were compared to vertical growers. Conclusions: Horizontal growers had 80% frequency of appearance of whorls in their left hand and 67% in their right hand. Horizontal growers could easily be differentiated from the average and vertical growers because of the dominance of whorl pattern in their hands. Composite and arch pattern were more frequent in vertical growers when compared to horizontal and average growers.
Methylene blue sentinel lymph node biopsy for breast cancer learning curve in the COVID-19 era: How many cases are enough?
Authors: Azhar Yohana , Dewayani Birgitta M. , Lukman Kiki 
Published: July 2022

Background: Sentinel lymph node biopsy (SLNB) is now the gold standard procedure for early breast cancer with clinically negative lymph nodes (N0). According to the Indonesian Board-Certified oncologist surgeon, the learning curve for evaluating fellow breast surgeons to achieve this competency could have been shorter due to the COVID-19 pandemic. This study aims to see if the learning curve for sentinel lymph node (SLN) identification can be shortened and if imprint cytology (IC) can replace frozen sections (FS) for intraoperative analysis. Methods: Fellow breast surgeons were taught to perform SLNB on breast cancer patients. Intraoperative assessment and completion of axillary lymph node dissection (ALND) were performed in the first setting for standardization with the attending surgeon. Sentinel lymph node (SLN) identification was plotted on cumulative sum chart (CUSUM) limitations for evaluating the variability competency between attending surgeon and fellow surgeon based on a target identification rate of 85%. In addition, the accuracy of imprint cytology versus frozen section for identifying lymph node metastases was compared. Results: Consecutive 50 SLNBs were conducted during this period with attending and trainees split into two groups. After 13 consecutive tests, the CUSUM plot positively identified SLN as a significant achievement level of competency. Imprint cytology was shown to be inferior to frozen section cytology. The accuracy of imprint cytology is 91.8%, while the accuracy of frozen sections is 95.9%. Conclusion: According to a CUSUM chart based on a reasonable set of parameters, the learning curve for SLNB using methylene blue dye is reached after 13 consecutive positively detected SLN. Meanwhile, the frozen section is still the gold standard for determining the disorder of axillary lymph nodes, but the accuracy between the two methods can be comparable.
Neural crest cell-placodal neuron interactions are mediated by Cadherin-7 and N-cadherin during early chick trigeminal ganglion assembly
Authors: Halmi Caroline A. , Wu Chyong-Yi , Taneyhill Lisa A. 
Published: July 2022

Background: Arising at distinct positions in the head, the cranial ganglia are crucial for integrating various sensory inputs. The largest of these ganglia is the trigeminal ganglion, which relays pain, touch and temperature information through its three primary nerve branches to the central nervous system. The trigeminal ganglion and its nerves are composed of derivatives of two critical embryonic cell types, neural crest cells and placode cells, that migrate from different anatomical locations, coalesce together, and differentiate to form trigeminal sensory neurons and supporting glia. While the dual cellular origin of the trigeminal ganglion has been known for over 60 years, molecules expressed by neural crest cells and placode cells that regulate initial ganglion assembly remain obscure. Prior studies revealed the importance of cell surface cadherin proteins during early trigeminal gangliogenesis, with Cadherin-7 and neural cadherin (N-cadherin) expressed in neural crest cells and placode cells, respectively. Although cadherins typically interact in a homophilic (i.e., like) fashion, the presence of different cadherins on these intermingling cell populations raises the question as to whether heterophilic cadherin interactions may also be occurring during initial trigeminal ganglion formation, which was the aim of this study. Methods: To assess potential interactions between Cadherin-7 and N-cadherin, we used biochemistry and innovative imaging assays conducted in vitro and in vivo, including in the forming chick trigeminal ganglion. Results: Our data revealed a physical interaction between Cadherin-7 and N-cadherin. Conclusions: These studies identify a new molecular basis by which neural crest cells and placode cells can aggregate in vivo to build the trigeminal ganglion during embryogenesis.
Providers’ views on hormonal family planning methods: a qualitative study from Dosso, Niger
Authors: Maytan-Joneydi Amelia , MacLachlan Ellen W. , Agali Balki Ibrahim , Louis-Charles Kyria , Chaibou Sanoussi , Amadou Garba Souleymane , Moumouni Abdoul Nouhou , Speizer Ilene S. 
Published: July 2022

Background: Family planning (FP) providers play an important role in ensuring that clients are offered a full range of FP methods. This qualitative study explores providers’ views on three hormonal FP methods and why they think women may choose these methods in Niger. Methods: In-depth interviews were conducted with 24 FP providers in 24 government health centers in Dosso region, Niger between February-March 2020. Providers were asked about the suitability of different FP methods for women, including adolescents and married women with children. The interviews were translated and transcribed from Hausa and Zarma into French, thematically coded, and qualitatively analyzed. Results: Many providers believed discretion to be the most important method attribute for women. Providers report preferring implants for young clients because of the more rapid return to fertility. They disagreed on whether implants or injectables are more discrete for clients. That said, providers felt that clients appreciate the implant’s discretion, effectiveness, long-acting nature, and simplicity of use. Providers perceived that the majority of women choose injectables due to familiarity with the method, the fact that it is “invisible” to an outsider, and a lack of awareness of implants. Providers stated that while women may not initially choose the implant, when given more information about it, they were more open to adopting it, or switching from another method, and less likely to believe local myths. Providers believed that women find pills to be indiscreet. Conclusions: The findings highlight that while providers have perspectives on suitable methods for certain women, they also recognize that clients have their own preferences, such as how discreet the method is. As programs continue to expand method choice and new contraceptive technologies undergo research and development, highly desirable features such as discretion need to be considered.
Nanosized titanium dioxide particle emission potential from a commercial indoor air purifier photocatalytic surface: A case study
Authors: Koivisto Antti Joonas , Trabucco Sara , Ravegnani Fabrizio , Calzolari Francescopiero , Nicosia Alessia , Del Secco Benedetta , Altin Marko , Morabito Elisa , Blosi Magda , Costa Anna , Belosi Franco 
Published: July 2022

Background: Photocatalytic air purifiers based on nano-titanium dioxide (TiO2) visible light activation provide an efficient solution for removing and degrading contaminants in air. The potential detachment of TiO2 particles from the air purifier to indoor air could cause a safety concern. A TiO2 release potential was measured for one commercially available photocatalytic air purifier “Gearbox Wivactive” to ensure a successful implementation of the photocatalytic air purifying technology. Methods: In this study, the TiO2 release was studied under laboratory-simulated conditions from a Gearbox Wivactive consisting of ceramic honeycombs coated with photocatalytic nitrogen doped TiO2 particles. The TiO2 particle release factor was measured in scalable units according to the photoactive surface area and volume flow (TiO2-ng/m2×m3). The impact of Gearbox Wivactive on indoor concentration level under reasonable worst-case conditions was predicted by using the release factor and a well-mixed indoor aerosol model. Results: The instrumentation and experimental setup was not sufficiently sensitive to quantify the emissions from the photoactive surfaces. The upper limit for TiO2 mass release was <185×10-3 TiO2-ng/m2×m3. Under realistic conditions the TiO2 concentration level in a 20 m3 room ventilated at rate of 0.5 1/h and containing two Gearbox Wivactive units resulted <20×10-3 TiO2-ng/m3. Conclusions: The release potential was quantified for a photocatalytic surface in generalized units that can be used to calculate the emission potential for different photocatalytic surfaces used in various operational conditions. This study shows that the TiO2 nanoparticle release potential was low in this case and the release does not cause relevant exposure as compared to proposed occupational exposure limit values for nanosized TiO2. The TiO2 release risk was adequately controlled under reasonable worst-case operational conditions.