bluuebunny/crossref_metadata_2025_split huggingface dataset:
Escape of two-DOF dynamical system from the potential well
Authors: Engel A. , Ezra T. , Gendelman Oleg , Fidlin A. 
Published: August 2022

Abstract
We consider the escape of initially excited dynamical system with two degrees of freedom from a potential well. Three different benchmark well potentials with different topology are explored. The main challenge is to reveal the basic mechanisms that govern the escape in different regions of the parametric space and to construct appropriate asymptotic approximations for the analytic treatment of these mechanisms. In this study, numerical and analytical tools are used to classify and map the different escape mechanisms for a variety of initial conditions and to offer the analytic criteria predicting the system’s behavior for those cases.
Characteristics of Maxillary Sinus Ostia and Its Correlation With Anatomic Variations of the Osteomeatal Complex and Demographic Parameters
Authors: Eberliköse Hacer , Yılmaz Derviş , Gülen Orhan 
Published: August 2022

Abstract
Objectives
Knowledge of the anatomy and variations of the maxillary sinus is essential for high surgery success. This retrospective study aimed to evaluate the characteristics of the primary maxillary ostium (PMO) and accessory maxillary ostium (AMO) in association with demographic and sinonasal findings using cone beam computed tomography (CBCT) in a statistically highly reliable population.
Materials and Methods
The CBCT images of 385 patients were examined. The prevalence, localization, and height of PMO and AMO were evaluated with respect to sex, Schneiderian membrane (SM) thickness, concha bullosa, Haller Cells, and septal deviation.
Results
Analysis showed that the mean PMO diameter was 1.42 ± 0.62 mm. Although 11.6% of the PMO was in the inferior region, 60.4% was in the middle and 28% in the superior region. The mean AMO diameter was 2.55 ± 1.25 mm. Although 45.4% of the AMO was in the inferior region, 48% was in the middle and 6.6% in the superior region. Moreover, SM thickness seemed to influence the height.
Conclusion
The effect of age and SM on the height and diameter of PMO was found to be statistically significant.A significant positive relationship was found between PMO and AMO height. Also, a significant relationship was observed between the presence of AMO and septum deviation.
Clinical Relevance
: The presence of AMO, PMO diameter, and height should be added to the preoperative evaluation criteria for the success of sinus floor evaluation. Especially, sinonasal and demographic conditions should be carefully examined preoperatively for the long-term success of the surgery.
Comprehensive IR and NMR research of a newly Synthesized derivative of Imidazole–1,3,4–Oxadiazole
Authors: Sharma Palvi , Verma Kapil Kumar , Thakur shivalika , Kumari Ravina , Dalwal Vikrant 
Published: August 2022

Abstract
Background
Due to their critical applications in several domains or diseases, the compounds imidazole and oxadiazole have attracted a lot of interest. Oxadiazole is an anti-tussive, anti-inflammatory, anaesthetic, vasodilator, anti-helmintic, anti-allergic, and anti-platelet drug. Imidazole is an antifungal, anti-protozoal, and antihypertensive drug. The purpose of this study is to synthesize and characterize the derivative by using FTIR and 1H-NMR. The derivatives synthesis was completed. Ethyl 2-(1H-imidazol-1-yl) acetate is made in the first stage, and 2-(1H-imidazol-1-yl) acet-hydrazide is made using this Ethyl 2-(1H-imidazol-1-yl) acetate. The subsequent addition of 3-methoxybenzaldehyde followed by the addition of acetic anhydride led to the formation of the desired compounds. Studies using FTIR were conducted. Studies using 1H-NMR were also carried out.
Result
As a result, IR and 1H-NMR were used to characterise the synthesised material. A synthetic derivative's structure was established.
Conclusions
In conclusion, imidazole serves as the starting ingredient for the synthesis. The IR and NMR investigation was appropriately conducted, and this technique yields satisfactory results.
Predicting malignancy in thyroid nodules based on conventional ultrasound and elastography: the value of predictive models in a multi-center study
Authors: Zhang Ying , Huang Qiong-Yi , Wu Chang-Jun , Chen Qi , Xia Chun-Juan , Liu Bo-Ji , Liu Yun-Yun , Zhang Yi-Feng , Xu Hui-Xiong 
Published: August 2022

Abstract
Background: This study aimed to establish predictive models based on features of Conventional Ultrasound (CUS) and elastography in a multi-center study to determine appropriate preoperative diagnosis of malignancy in thyroid nodules with different risk stratification based on 2017 Thyroid Imaging Reporting and Data System by the American College of Radiology (ACR TI-RADS) guidelines.Methods: Five hundred forty-eight thyroid nodules from three centers pathologically confirmed by the cytology or histology were retrospectively enrolled in the study, which were examined by CUS and elastography before fine needle aspiration (FNA) and surgery. Characteristics of CUS of thyroid nodules were reviewed according to 2017 ACR TI-RADS. Binary logistic regression analysis was used to develop the prediction models based on the different risk stratification of CUS features and elastography which were statistically significant. Values of predictive models were evaluated regarding the discrimination and calibration.Results: Binary logistic regression showed that patients’ age, taller-than-wider, lobulated or irregular boundary, extra-thyroid extension, microcalcification and the elastic parameter of Virtual touch tissue imaging quantification (VTIQ) max were independent predictors for thyroid malignancy (p<0.05) in the ACR model and showed the area under the curve (AUC) in training (0.912) and validation cohort (internal and external: 0.877 vs 0.935). Predictive models showed predictors in ACR TR4 and TR5 for malignancy and diagnostic performance of AUC in training, internal and external validation cohort respectively: the VTIQ max (p < 0.001) with AUC of 0.809 vs 0.842 vs 0.705 and the age, taller than wide, VTIQ max variables with AUC of 0.859 vs 0.830 vs 0.906 in validation cohort. All predictive models have better calibration capabilities (p>0.05).Conclusions: Predictive models combined CUS and elastography features would aid clinicians to make appropriate preoperative diagnosis of thyroid nodules among different risk stratification. The elastography parameter of VTIQ max has the priority in distinguishing thyroid malignancy with moderately suspicious (ACR TR4).
Global trend and risk factors of the disease burden for pharynx and larynx cancers between 1990 and 2019: A systematic analysis of the Global Burden of Disease Study 2019
Authors: Huang Ao , Wu Xing-liang , Song Jia , Wang Yu-Ting , Yao Yin , Liu Zheng , Wang Heng 
Published: August 2022

Abstract
Background: Pharynx and larynx cancers (PLCs) are the most frequent cancers in head and neck and significantly affect the quality of life of patients. A detailed study examining the mortality rate and etiology of PLCs is lacking.Methods: Data on mortality and disability-adjusted life-years (DALYs) were extracted from the Global Burden of Disease Study 2019. The estimated annual percentage change (EAPC) was calculated to explain the dynamic change in age-standardized mortality and DALY rates at multiple levels. Results: Between 1990 and 2019, the total number of deaths due to PLCs increased by 60.7%, from 192.38 thousand in 1990 to 309.16 thousand in 2019, and the total DALYs due to PLCs increased by 49.41%, from 5.91 million in 1990 to 8.83 million in 2019. The age-standardized mortality rate declined for larynx cancer and nasopharynx cancer but increased slightly for other pharynx cancer. The global burden of PLCs was significantly higher in men aged 50 to 70 years. Countries with relatively low sociodemographic index (SDI) had the greatest disease burden. The leading risk factors for mortality due to PLCs were smoking and alcohol use in different SDI regions, and the influence of risk factors was significant in men.Conclusion: Countries with relatively low SDI and middle-aged and older men had the greatest burden of PLCs. Building better health care systems in relatively low SDI countries and improving strategies of alcohol control should be a priority in health policy.
Ultrasound and Microwave-Assisted Extraction of Proteins from Coffee Green Beans: Effects of Process Variables on the Protein Integrity
Authors: Prandi Barbara , Massimo Martina , Tedeschi Tullia , Rodríguez-Turienzo Laura , Rodríguez Óscar 
Published: August 2022

Abstract
The demand for proteins is constantly increasing and green extraction methodologies are needed to achieve environmental sustainability goals. The recovery of the by-products of the agri-food chain has also become a priority from a circular economy perspective. Some by-products are still little exploited for the extraction of proteins, such as coffee by-products. In this work, various innovative extraction technologies were applied to recover the protein fraction from the non-compliant coffee green beans (CGB), using a methodological approach that allowed to correlate the process parameters with the final quality of the extracted proteins. The ultrasound-assisted extraction (UAE) technique has been shown to have a minor impact on the quality of the proteins, thanks to the possibility of refrigerating the system, while the microwave-assisted extraction (MAE) shows a certain degree of degradation due to the high temperatures reached. The results indicate that strict temperature control is required during alkaline extraction to preserve the quality of the protein fraction.
age is the main prognostic factor regarding functional outcome in intertrochanteric fracture
Authors: Babagoli Mazyar , Soleimani Mohammad , Golbakhsh Mohammadreza , Shafiei Seyyed Hossein , Raeini Amirhossein Ghaseminejad 
Published: August 2022

Abstract
Objectives: The type of fracture, type of surgery, and patient comorbidities affect the possibility of achieving the best postoperative outcome in intertrochanteric fractures. We aim to evaluate the effect of the patient’s clinical and paraclinical condition before and after surgery on postoperative functional outcomes with the Harris hip score instrument.Design: RetrospectiveSetting: single-centerPatient/Participants: This study included 310 patients undergoing intertrochanteric fracture surgery at one center from November 2016 to September 2020.Intervention: Patient demographic, comorbidity and pre and postoperative laboratory data, complication, and Harris Hip Score data were collected.Main Outcome Measurements: Multivariate logistic regression was used to determine the effect of demographic characteristics (sex, age, type of fracture regarding AO/OTA classification, height, weight, body mass index), habitual and past medical history( hypertension, ischemic heart disease, diabetes mellitus, thyroid malfunction, cancer, osteoporosis, smoking) lab data (Complete blood cell, blood sugar, Blood Urea Nitrogen (BUN), Creatinine (Cr), Na, and K ), surgery-related factors (Anesthesia time and type, intraoperative blood transfusion, postoperative blood transfusion, and operation time), duration of admission to surgery and anticoagulant consumption after a median of 29.84 months (range: 5-69.4 months ) follow-up on Harris Hip Score of patients undergoing intertrochanteric fracture surgery.Results: When Harris Hip Score compared between following characteristics the distribution was significant: AO/OTA classification (p=0.037), sex (p=0.017), hypertension (HTN) (p=0.001), Diabetes mellitus (DM) (p=0.038), Anticoagulant consumption (p=0.01), smoke (p=0.000), osteoporosis (p=0.001), anesthesia type (p=0.003), age (p=0.000), hemoglobin (Hb) before surgery (p=0.004), height (p=0.000), BUN before surgery (p=0.010), and Δ Na (p=0.046). in multivariable regression age is the main prognostic factor and Age >69.5 is prognostic factor for poor and fair Harris Hip Score.Conclusion: To improve the functional outcomes in IT fractures, the patient-related factors (underlying disease and the use of drugs, anemia status as well as electrolytes) and fracture type should be considered. Among the all these, age remains the main prognostic factor.Level of Evidence: Prognostic Level III.
miR-5088-5p inhibitor reduces radiation-induced malignancy by decreasing Slug
Authors: Seok Hyun Jeong , Choi Jae Yeon , Yi Joo Mi , Bae In Hwa 
Published: August 2022

Abstract
Purpose
Radiotherapy is widely used for cancer treatment, but paradoxically, surviving cancer cells can become malignant, leading to tumor recurrence or metastasis. Therefore, in order to increase the effectiveness of radiotherapy, efforts to reduce radiation-induced malignancy are absolutely necessary. As a tool, microRNA simultaneously regulates the expression of multiple target mRNAs, so it has significant potential as an effective therapeutic agent. The main objective of this study is to elucidate the malignant mechanism of radiation-induced miR-5088-5p and to prove the efficacy of miR-5088-5p inhibitor for mitigating malignancy, thereby demonstrating its applicability as a therapeutic agent to increase the efficiency of radiotherapy.
Methods
To analyze the relationship between radiation and miR-5088-5p expression, miR-5088-5p levels were determined by qRT-PCR in the plasma of breast and lung cancer patients with or without radiotherapy. MSP and qMSP assays were used to confirm the methylation of radiation-induced miR-5088-5p. To determine whether miR-5088-5p inhibitor reduces radiation-induced malignancy by decreasing Slug, we used wound healing, invasion, sphere formation, Western blot, qRT-PCR assays, and in vivo mouse xenograft metastatic model.
Results
It was confirmed at both the cellular and animal model that miR-5088-5p, which showed higher expression in the plasma of breast cancer and lung cancer patients with radiotherapy, enhances tumor malignancy by enhancing its expression through hypomethylation of its promoter by radiation. On the other hand, it was shown that miR-5088-5p inhibitor reduced the mechanism of radiation-induced malignancy.
Conclusions
Collectively, miR-5088-5p inhibitors have shown potential as a combination therapy to enhance radiotherapy effectiveness by reducing radiation-induced malignancy.
Endoscope-Assisted Manipulation of Chronic Subdural Hematoma Provide a Novel Solution for Eliminating Septum and Inner Membrane Leading to Reducing Recurrence
Authors: Hong Kun-Ting , Hsu Shih-wei , Chen Chao-Hsuan , Hueng Dueng-Yuan , Chen Yuan-Hao , Ju Da-Tong , Tang Chi-Tun 
Published: August 2022

Abstract
OBJECTIVE: The canonical burr-hole craniostomy with drainage (BHC-D) has been main treatment for the chronic subdural hematoma. However, complicated situation such as organized clot or compartmentation may mandate the recurrent chronic subdural hematoma (CSDH). Our team has introduced a novel technique applying the endoscope for tearing inner membrane and septum in addition to evacuating the hematoma in the subdural space where the in-line visualization not being accessed. The novel concept of practice may provide a clinical value with optimizing the future recurrence. MATERIALS and METHODS: Two hundred and twenty-nine cases of CSDH were enrolled and analyzed. Among them, 13 were endoscopically treated and the surgery details were recorded. The 0- degree and 30-degree, 2.7 mm endoscope (Storze, Turlington, Germany) were applied after a BHC. The arachnoid knife for microsurgery is utilized for tearing the inner membrane to open up the compartments. The demographic data including comorbidities, surgical parameters and follow up of images were evaluated. RESULTS: Compared with non-endoscope-assisted operated patients (non-Endo group), the 13 endoscope-assisted membranectomy (EM) patients (Endo group) demonstrated no difference with regard to gender, age, body mass index (BMI), trauma and other diseases, or use of anticoagulation agent. Although the surgery time spent for the Endo patients were longer (128.53 ± 49.56 min) than non-Endo group (65.18 ± 32.89 min), intriguing, no recurrence was found among Endo group, while high to 6.5% happened among the non-Endo patients in outpatient follow-up. CONCLUSION: Our proposed endoscope-assisted membranectomy (EM) has provided a practical technique aiming to reduce recurrence and optimize the surgical outcome.
An Estimate for the Numerical Radius of the Hilbert Space Operators and a Numerical Radius Inequality
Authors: RASHID M. H.M. , BANI-AHMAD Feras 
Published: August 2022

Abstract
We give several sharp inequalities involving powers of the numerical radii and the usual operator norms of Hilbert space operators. These inequalities , which are based on some classical convexity inequalities for nonneg-ative real numbers and some operator inequalities, generalize earlier numerical radius inequalities.
Association of candidate genes (ALR2, RAGE, and VEGF) polymorphisms with diabetic retinopathy in type 2 diabetic patients in Khyber Pakhtunkhwa, Pakistan
Authors: Jehanzeb Mamoona , Khan Najeeb Ullah , Hussain Mahfooz , Subrina Jesmin , Mustafa Adeela 
Published: August 2022

Abstract
AIM: To evaluate the aldose reductase (ALR2, rs759853), receptor for advanced glycation end products (RAGE, rs2070600), and vascular endothelial growth factor (VEGF, rs833061) association with diabetic retinopathy in type 2 diabetic patients in Khyber Pakhtunkhwa population.Methods: A Case control study was conducted on a total of 550 subjects consisting of 186 with diabetic retinopathy (DR) having type 2 diabetes, 180 had type 2 diabetes (T2DM), and 184 healthy controls (HC). All the samples were subjected to DNA isolation using salting-out method followed by SNP genotyping through Tetra-ARMS PCR. Chi square and Exact Fischer tests were used for allele and genotype distribution. Odd ratio and confidence interval values were found out by online software Medcalc Odd ratio Calculator.Results: Multiple parameters such as random blood sugar (RBS) (p<0.001), fasting blood sugar (FBS) (p<0.001), HbA1c (p<0.001), total cholesterol (p<0.001), LDL (p<0.001), HDL (p<0.001), BMI (p<0.001) and hypertension (p=0.018) showed strong association with DR as compared to DM and HC. Our results showed that VEGF rs833061 (p<.001) and RAGE rs2070600 (p<.001) polymorphism was strongly associated with an increased risk of DR. The odd ratio of CC genotype in VEGF (0.262, 95% CI=0.129-0.531) and AA genotype in RAGE (0.59, 95% CI=0.032-0.110) was noted. However, the significance in ALR2 rs759853 gene polymorphism was observed at (p=0.001). Conclusion: There is a statistically significant association of VEGF rs833061 and RAGE rs2070600 with diabetic retinopathy in type 2 diabetic patients. Also, this is the first study to report the association of RAGE with diabetic retinopathy in type 2 diabetes in Khyber Pakhtunkhwa population.
Removal of breast cancer artifact based on auto-correlation function
Authors: Pour Javad Nouri , Pourmina Mohammad-Ali , Ghalamkari Behbod , Moghadasi Mohammad-Naser 
Published: August 2022

Abstract
Ultra-wide band (UWB) micro-wave imaging has been proposed as a new method to diagnose breast tumors. An artifact is considered one of the imaging issues. This study focuses on current methods in this field. First, different artifact removal approaches are reviewed, where the aims of most signal processing methods include skin artifact removal and diagnosis of the existence and position of malignant lesions. Then, to improve the artifact removal, we design a signal with linear frequency modulation (LFM) intra-pulse modulation and constant pulse repetition interval (PRI) inter-pulse modulation. Here, the received and submitted signs of the skin are removed by using the auto-correlation function. The simulation results show that this proposed method has minor errors compared to the other methods.
Genome-wide identification and expression analysis of GATA gene family in wheat
Authors: Sun Yumeng , Li Chunyue , Chang Qihang , Guo Changhong , Bai Yan 
Published: August 2022

Abstract
Background: GATA gene family is a transcription factor in eukaryotes, which plays an important role in plant growth and development, cell differentiation, decomposition and apoptosis, and plant response to environmental changes. However, no genome-wide analysis of this gene family has been reported in wheat.Results: In this study, 79 members of wheat GATA family were identified based on wheat genome information and named TaGATA01 ~ TaGATA79. The gene structure, phylogeny, chromosome distribution, physical and chemical properties, conserved motifs and cis-acting elements of TaGATA family members were systematically analyzed by bioinformatics methods. The results showed that TaGATA family members encoded 146 ~ 499 amino acids, with isoelectric points ranging from 4.76 to 10.12 and instability index ranging from 41.99 to 86.02, which were all unstable proteins; Phylogenetic tree results showed that 79 TaGATA transcription factors were divided into six subfamilies, and members of the same subfamily had highly similar gene structure; MG2C was used to analyze the chromosomes, and it was found that TaGATA family members were unevenly distributed on 21 chromosomes; Plant CARE was used to identify 10 Plant hormone-related elements and 4 stress-related elements, among which TaGATA12 contained the most cis-acting elements and TaGATA55 contained the least cis-acting elements. qRT-PCR was used to analyze the expression levels of 23 TaGATA genes in different tissues and different abiotic stresses. It was found that most of the genes were highly expressed in stem, but few in panicle; Most genes were up-regulated under ABA stress and some genes were down-regulated under low temperature stress.Conclusions: It was found that GATA transcription factors may be involved in the regulation of low temperature, drought and other stress responses of wheat, and play an important role in plant response to abiotic stress. This study analyzed the bioinformatics characteristics of each member of wheat GATA family and laid a theoretical foundation for the subsequent research on its functions.
Structure Design verification with Electrical Dynamic, Thermal Stress and Current Sharing Analysis for CRAFT Converter
Authors: Wang Zhongma , Shi Chaoyi , Gao Xianhe , Zhang Sheng , Lu Jun , Huang Liansheng 
Published: August 2022

Abstract
During the design process of fusion power supplies, structure designs is a very important step for safety operation of fusion device. In this paper, the electric dynamic analysis based on the worst fault current and thermal stress analysis with maximum steady temperature are finished, respectively. In addition, a simple research method of current sharing characteristics of converter bridge arm by Q3D modeling with Simplorer is proposed, the results show that the current sharing characteristics are prosperous. Finally, the structural design of CRAFT converter meets the requirements, and the prototype will be manufactured later.
Effect of concentration of polyurethane on the anticorrosive property of Vanillin based benzoxazine - A Thermal, Electrochemical and Quantum approach
Authors: K Jayanthi , M Sivaraju , P Shanmugasundaram 
Published: August 2022

Abstract
Benzoxazine monomer prepared from vanillin and n-butylamine is characterized by 1H NMR, 13C NMR, FT-IR and UV visible spectroscopic techniques. The synthesized monomer is coated on the mild steel with polyurethane (PU) hardener and cured. The thermal properties of the monomer with and without polyurethane hardener were studied by TGA and DSC methods. The effect of various concentrations of the PU hardener with the benzoxazine monomer on hardness, water absorption, and gel absorption was investigated. Various concentrations of PU hardener with benzoxazine coating (VaBZ-PU) on the mild steel were investigated by the electrochemical impedance and polarisation studies. The study revealed that the increasing concentration of PU in the coating with the benzoxazine increased their thermal, chemical and anticorrosive properties. The DFT calculations are performed to support the anti-corrosive ability of the material.