bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Fast Ripples Recording with Model-Guided Design of Microelectrodes
Authors: Al Harrach Mariam , Dauly Gautier , Seyedeh-Mousavi Hajar , Dieuset Gabriel , Benquet P , Ismailova Esma , Wendling Fabrice 
Published: December 2022

<p>Objective: Microelectrodes allow for the recording of neural activities with a high spatial resolution. However, their small sizes result in their high impedance, therefore, leading to a high thermal noise and a poor signal- to-noise ratio. In the context of drug-resistant epilepsy, efficient Fast Ripples (FRs; 250-600 Hz) detection can help in pre-surgical investigations and delineation of epileptic zones. Consequently, good quality recordings with a high spatial resolution promise to improve the surgical outcome. This work aims at proposing a reliable model-based microelectrode design that is optimized for FRs recordings and detection.</p>
<p>Methods: A 3D microscale computational model simulates the FRs generated in the CA1 subfield of the hippocampus. It couples with the electrode-tissue interface characteristics that account for the microelectrode’s biophysical properties and their impact on the recorded signal. To validate this model, analyses of the electrode’s geometrical (diameter, position, and direction) and physical (materials, coating) characteristics were con- ducted in order to propose an optimal microelectrode de- sign tuned for FRs recording. In addition, </p>
<p>Results: Experimental signals were recorded from mice in the hippocampal CA1 subfield from different electrodes for comparison. ( between stainless steel, gold and gold coated with poly(3,4-ethylene dioxythiophene) /Poly(styrene sulfonate) (PEDOT/PSS)).</p>
<p>Conclusion: Both in silico and in vivo quantified results show a clear improvement in FRs observability using PEDOT/PSS coated microelectrode. </p>
Pertuzumab in Combination with Trastuzumab and Docetaxel in the Neoadjuvant Treatment for HER2-Positive Breast Cancer
Authors: Vieira Cláudia , Borges Andreia , Pereira Filipa F. , Antunes Pedro , Redondo Patrícia , Antunes Luís , Lopes José M. , Gonçalves Francisco R. , Borges Marina , Bento Maria J. 
Published: December 2022

ABSTRACT

Introduction
This study aims to assess safety and effectiveness of pertuzumab in combination with trastuzumab and docetaxel in the neoadjuvant treatment (NeoT) of HER2-positive breast cancer.

Methods
Two consecutive retrospective cohorts (n = 94, 2012–2015 and 2015–2017) of adult women with HER2-positive breast cancer, receiving NeoT at the breast clinic in Portugal (IPO-Porto), were followed. All patients had surgery and received trastuzumab as adjuvant therapy. The 2012–2015 cohort received doxorubicin, cyclophosphamide, docetaxel plus trastuzumab, whereas the 2015–2017 cohort was treated with the same protocol plus pertuzumab.

Results
The 2012–2015 cohort was older (median 53 years), with locally advanced tumors (48.1%), mostly hormone receptor positive (59.3%). The 2015–2017 cohort was younger (median 43 years) with 60% operable tumors. Pathologic complete response (pCR) improved in the second cohort, while maintaining a good safety profile and tolerability. Clinical staging (p = 0.001) and hormone receptor (p = 0.003) were significant predictors of pCR, but not treatment regimen (p = 0.304).

Conclusion
Further research with larger samples and longer follow-up is needed to understand the clinical differences. Clinical effectiveness of treatment should also be measured through overall and progression-free survival.
MOVIMENTOS SOCIAIS URBANOS E A TRAJETÓRIA DO URBANISMO
Authors: Bitoun Jan 
Published: December 2022

Procuro recompor a trajetória do urbanismo nas suas relações nos últimos cinquenta anos com os movimentos sociais urbanos. Formula-se a hipótese de que, no contexto da cidade latino-americana, o principal desafio para esses movimentos sociais era de levar os urbanistas a encontrar soluções para um problema que não havia sido resolvido na Europa: o do habitat de segmentos sociais em situações precárias e sem vínculos fixos com o mercado de trabalho, apresentando então diferenças com a questão do habitat operário. A análise dessa trajetória no Recife, com base em documentos fundantes das intervenções urbanísticas demonstra que as conquistas políticas e jurídicas não foram acompanhadas por grandes inovações no campo das técnicas urbanísticas. Essas deram prioridade sucessivamente a um tratamento técnico – funcionalista e à concepção de grandes projetos urbanos orientados pela visão da competição interurbana. Tais orientações parecem ter dificultado a continuidade intergeracional das lutas urbanas características do início do período.
FORMAS ESPACIAIS E PAPÉIS URBANOS
Authors: Sposito Maria Encarnação Beltrão 
Published: December 2022

A análise das relações entre formas espaciais e papéis urbanos é realizada neste artigo, a partir das relações e distinções entre a cidade e o urbano. São valorizadas as determinações contemporâneas do processo de urbanização que redefinem as formas de expansão territorial das cidades e os conteúdos e práticas socioespaciais atinentes ao urbano. As articulações e diferenças entre três pares de qualidades do processo de urbanização e das cidades são a base da análise: transição e transitório, extensão e intensidade, mobilidade e imobilidade.
REGIÕES RETICULARES
Authors: Limonad Ester 
Published: December 2022

Este ensaio introduz a ideia de regiões reticulares não-euclidianas. E o faz movido pela intenção de avançar teórica e metodologicamente, em um nível mais geral, na compreensão da organização e da produção contemporânea do espaço social, e em um nível particular, para situar a questão urbana e as tendências recentes da urbanização no Brasil. Essa categoria aparece como essencial para a construção de uma economia política do espaço, bem como para contribuir para explicar os fundamentos da divisão espacial do trabalho e o funcionamento da economia do sistema capitalista, por permitir analisar as atuais continuidades espaço-temporais que ora se estabelecem, verticalmente alterando as relações de centralidade prevalecentes.
Nusyuz Penyelesain Konflik Keluarga Dalam Hukum Islam (Teori Dan Praktinya Di Indonesia)
Authors: Jalil Abd 
Published: December 2022

Ikatan perkawinan merupakan suatu tujuan yang sangat utama dalam Islam. Nikah dilaksanakan untuk selamanya agar suami istri bersama-sama dapat mewujudkan rumah tangga impian sebagai tempat berlindung, menikmati curahan kasih saying dan dapat memelihara anak-anaknya sehingga mereka tumbuh dengan baik.
Konflik keluarga datang kapan dan diamana saja, jika tidak selesaikan akan berakhir pada pencerain. Islam sebagai agama sempurna memberikan pedoman cara menyelesaikan konflik keluarga secarah bijaksana. dengan menjunjung tinggi harat dan martabat perempuan dengan memberkan hak-haknya. Begitu juga dengan laki-laki berikan solusi tampa merendahkan dan mendiskriminalkan perempuan.
Response of Lowland Rice to Rice Crop Specific Npk Fertilizer at Badeggi Central Nigeria
Authors: Ibrahim, P. A. , Gbanguba, U. A. , Madukwe D 
Published: December 2022

The trial was carried at National Cereals Research Institute Lowland Experimental field in the year 2019 and 2020 to evaluate the response of lowland rice to application of Rice Crop Specific NPK fertilizer 1and commercial NPK fertilizer which was applied at two levels each recommended blanket rate of 80:40:40 NPK/ha and higher rate of 120: 60:60 NPK/ha for lowland rice as well as the control (Zero fertilizer). The results indicated that application of fertilizer has significant effects on rice growth there by increased the height of rice at different weeks after fertilizer application compared to control. Rice straw and grain yield production was significantly affected with application and the rates. RCS fertilizer applied at 120:60:60/ha produced higher tonnage of rice straw and grain while application of RCS fertilizer at 80:40:40/ha produced similar rice straw and grain yield with application of NPK 15: 15:15: at rate of 120:60:60/ha. There the adoption of RCS-NPK formulation at rate 80:40:40 kg/ha is recommended against the higher rates from commercial NPK to save cost for the resources poor farmer.
La calificación jurídica del vínculo plataforma - repartidores
Authors: Foddanu María Julia 
Published: December 2022

Sumario:
I. Introducción. II. La calificación jurídica del vínculo plataforma-repartidores. Posturas. III. Los indicios de laboralidad de la OIT. IV. El accionar de la policía del trabajo y su convalidación judicial. V. Reflexiones Finales.
Peculiarities of the seed productivity formation of tyfon (Brassica campestris var. oleifera f. biennis D.C. × B. rapa L.) plants under the effect of cultivation technology
Authors: Tsaruk V. I. , Rakhmetov D. B. 
Published: December 2022

Purpose. To reveal the peculiarities of the formation of indicators of individual seed productivity of tyfon plants under the effect of the agrotechnical components, such as the width of the rows and the rates of mineral fertilizers.
Methods. The research was conducted in the years 2018–2021 at the Nizhyn Agricultural Technical Institute (Chernihiv region) according to generally accepted methods. The scheme of the field experiment provided for the cultivation of tyfon variety 'Orakam' under different methods of sowing (width between rows 15, 30 and 45 cm) and rates of mineral fertilization (without fertilizers, N80P60K60 and N120P90K90).
Results. The highest indicators of seed productivity were obtained at a row width of 15 cm against the background of the application of the mineral fertilizers N80P60K60. In particular, the weight of seeds from one plant in this version of the experiment was 8.17 g, of which 1.72 g was the share of the main stem, and the remaining 6.45 g was the share of the side shoots of the first order. In the control option (width between rows 15 cm without fertilizing), these indicators were 7.45; 1.45 and 6.00 g, respectively. In the case of increasing the width of the rows to 30 and 45 cm on the background of application of N80P60K60, the weight of seeds per plant was lower compared to the 15 cm option by 0.36 and 1.15 g, and on the background of N120P90K90 – by 0.50 and 1.18 g, respectively. In all variants of the experiment, the main share in the structure of the individual productivity of crop plants (~ 80%) was occupied by the seed crop formed on their lateral shoots. Accordingly, the share of the yield from the main stem was approximately 20%. The variation of this percentage ratio depending on the impact of the investigated agrotechnical measures (both fertilizer rates and the method of sowing) had only a tendency character, as it did not exceed the experimental error.
Conclusions. An increase in the width of the rows in the cultivation of tyfon leads to a significant decrease in the individual productivity of its plants, regardless of the use of fertilizers. Moreover, a clear regularity is followed: the wider the rows, the smaller the seed mass from one plant. To a large extent, the formation of seed productivity of crop plants is influenced by the application of fertilizers. More effective in this regard is the N80P60K60 rate, in the plots with which, for all treatments of the width of the rows, a significant increase is observed compared to the control of the seed mass from the plant. At the same time, when the rate of fertilizers increased to N120P90K90, a significant decrease in the weight of seeds per plant was found, compared to both the control without fertilizers and N80P60K60. The most optimal option for combining both elements of agricultural technology is the cultivation of tyfon at a row width of 15 cm against the background of N80P60K60 application.
Optimization of nitrogen nutrition in increasing the productivity of sugar beet
Authors: Ivanina V. V. , Daniuk M. S. 
Published: December 2022

Purpose. Investigate the effect of doses and methods of applying nitrogen fertilizers on the productivity of sugar beets after plowing in for fertilizer of winter wheat straw.
Methods. Short-term field and analytical.
Results. The results of research on the effect of doses of nitrogen fertilizers applied in spring under pre-sowing cultivation over the background of straw and mineral fertilizers applied under plowing on the productivity of sugar beet are given. The yield of sugar beet, sugar content in roots and biological productivity of crop under the use of alternative organic-mineral fertilizations were determined.
Conclusions. It was established that alternative organic-mineral fertilizations significantly increased the biological productivity of sugar beet. Application of mineral fertilizers in autumn under deep plowing in a dose of N90Р90К90 against a background of 5 t/ha of straw was determined to be less biologically productive: the yield of roots – 49.9 t/ha, sugar harvest – 8.73 t/ha, exceeding the control without fertilizers by 8.7 and 1.56 t/ha, respectively. The application of N90 in pre-sowing cultivation against the background of 5 t/ha of straw + P90K90 under plowing was determined to be the most optimal for sugar beet: root yield – 55.8 t/ha, sugar harvest – 9.71 t/ha, exceeding the control without fertilizers by 14.6 and 2.54 t/ha, respectively. Increasing the nitrogen dose in the spring by more than 90 kg/ha was not accompanied by a significant increase in yield, reduced the sugar content in roots, and therefore was ineffective.
Features of the use of sesame flour in the production of health confectionery products in restaurants
Authors: Yevchuk Ya. V. , Liubych V. V. , Voitovska V. I. , Kononenko L. M. 
Published: December 2022

Purpose. Determine the suitability of sesame flour for the production of health cakes.
Methods. Laboratory, mathematical and statistical, physicochemical, expert.
Results. The volume of the cake without the addition of sesame flour was 223 cm3/100 g. In the treatment with the largest amount of the flour (20%) the volume 219 cm3/100 g, which was not significant (LSD0.05 = 11). The humidity of the end product met the requirements of the standard and did not vary significantly over the experimental treatments. The acidity of the cake with the addition of sesame flour was higher; however, it met the standards. Apparently due to the components of sesame flour. The ash content did not meet the requirements of the standard due to the higher content of mineral elements in sesame flour. The porosity of the cake also did not vary a lot over the experimental treatments. The cooking quality of the cakes with the addition of sesame flour was high. It was found that adding sesame flour in the amount 5–15% of the dough does not change the cooking quality of the cake. The highest overall score was 9. The addition of 20% sesame flour reduced the overall score to 7 points (22%), but this still was high. It should be noted that with the addition of 5–15% of sesame flour, the surface of the cake had small cracks, porosity with small thick-walled pores. In addition, the shape of the end product in all the experimental treatments was correct, the surface did not burn, the color was brown. The color of the lower crust was different from the color of the upper and side crust and had a well-baked crumb. The taste and smell were characteristic of this type of cake, without extraneous taste and smell.
Conclusions. The addition of sesame flour does not change the quality of the cake. It is optimal to add 10–15% of sesame flour by weight of the dough to the recipe. The volume of the cake was 220–221 cm3, humidity 17.0–17.1%, acidity 1.2 degrees, ash content 0.13–0.14%, porosity 54%. The overall cooking score of the cake was very high, 9 points. The quality of such a product meets the established standards.
Productivity of switchgrass (Panicum virgatum L.) varieties of different terms of ripening
Authors: Boiko I. I. , Manzii O. P. , Nebykov M. V. , Tretiakova S. O. 
Published: December 2022

Purpose. To determine the formation of productivity (yield of vegetative mass, content of cellulose and hemicellulose, zinc and iron) of different varieties of switchgrass.
Methods. Research on the agrotechnology of switchgrass was conducted at the Yaltushkiv Experimental Breeding Station. The predecessor of switchgrass was winter wheat. The experiments were set up in accordance with generally accepted methods. Yield was determined in sections, cellulose content, hemicellulose content – zinc and iron content – by atomic absorption spectrometry.
Results. It was found that the yield of switchgrass biomass varied significantly over the studied varieties. Thus, the highest yield was obtained by growing varieties ‘Shelter’ (mid-ripening), ‘Cave-in-Rock’ (mid-ripening), ‘Morozko’ (mid-ripening), ‘Carthage’ (late-ripening) and ‘Kanlow’ (very late-ripening) and ranged between 19.3 and 21.6 t/ha at actual humidity or 11.1–16.7 t/ha of dry mass. However, the highest yield of dry mass was provided by growing varieties ‘Morozko’ and ‘Kanlow’, 16.7–17.9 t/ha. Yield of early-ripening switchgrass varieties was at the level of 12.9–16.7 t/ha at actual humidity or 8.9–11.5 t/ha of dry weight. It should be noted that of the seven mid- and late-ripening varieties, five had dry weight yield at the level of two early-ripening varieties (‘Forestburg’ and ‘Nebraska’). Thus, the highest yield of biomass is provided by growing mid- and late-ripening varieties of switchgrass. The highest content of cellulose was in late-ripening varieties of switchgrass. No significant difference was found between early and late-ripening varieties. It should be noted that the content of hemicellulose almost did not change over the studied varieties and ranged between 14.1 and14.7%. In the dry biomass of switchgrass, the cellulose content was 1.4–1.5 times higher in comparison with the biomass of actual moisture (64.2–68.0). The hemicellulose content was 20.4–21.3%, depending on the variety of switchgrass. It should be noted that their content did not change significantly over the studied switchgrass varieties, both at actual humidity and in terms of dry weight. The iron content was 2.6–2.7 times higher than zinc 1.23–1.27 mg/100 g.
Conclusions. The yield of biomass of switchgrass varies from 12.9 to 21.6 t/ha at actual humidity that equals 8.9 to 16.7 t/ha of dry mass. The highest yield of dry mass is provided by the cultivation of switchgrass varieties ‘Morozko’ and ‘Kanlow’ (16.7–17.9 t/ha). The biomass contains 45.2–46.9% of cellulose, 14.2–14.5% of hemicellulose, 0.46–0.47 mg/100 g of zinc and 1.26 mg/100 g of iron. It is recommended to use them in breeding programs to create high-yielding varieties of switchgrass.
FAKTOR-FAKTOR YANG MEMPENGARUHI KEJADIAN ASFIKSIA PADA BAYI BARU LAHIR
Authors: Ningsih Zela , Sundari Sri , Yuliasri Tita Restu 
Published: December 2022

Latar Belakang: Angka kematian perinatala (Perinatal Mortality Rate) di negara berkembang (50/1000) adalah lima kali lebih tinggi daripada negara maju (10/10000). Kejadian asfiksia di Indonesia mencapai 27,0%. Kejadian asfiksia di RSUD Panembahan Senopati Bantul dari Januari - Desember 2020 sebanyak 300 kasus. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi kejadian asfiksia pada bayi baru lahir di RSUD Panembahan Senopati Bantul, Yogyakarta Tahun 2021. Metode: Penelitian ini merupakan penelitian deskriptif analitik, pendekatan retrospektif, populasi penelitian 300 responden dan sampel 171 responden., pengambilan sampel menggunakan teknik Simple Random Sampling, instrumen penelitian yang digunakan checklist dan dianalisis menggunakan chi square SPSS for windows versi 19.0. Hasil: Hasil analisis data menunjukkan karakteristik kejadian asfiksia berdasarkan dari usia ibu > 25 tahun 135 (78,9%), pendidikan SMA 105 (61,4%), pekerjaan IRT 109 (63,7%), Paritas 2-4 114 (66,7%), umur kehamilan cukup bulan 154 (90,1%), berat badan lahir normal 151 (88,3%), tidak ada riwayat penyakit 134 (78,4%), riwayat persalinan dengan tindakan 94 (55,0%). tidak mengalami KPD 139 (18,7%), warna air ketuban jernih 118 (69,0%). Kejadian asfiksia sedang 80 (46,8%). Riwayat penyakit p-value sebesar 0,281 > 0,05, riwayat persalinan p-value 0,045 > 0,05, variabel air ketuban p-value sebesar 0,022 > 0,05, ketuban pecah dini p-value sebesar 0,881 > 0,05. Kesimpulan: Terdapat hubungan faktor-faktor yang mempengaruhi kejadian asfiksia dengan kejadian asfiksia pada bayi baru lahir di RSUD Panembahan senopati Bantul berdasarkan Riwayat persalinan dan air ketuban.
Os veículos poéticos de Jean Cocteau - exercício de ‘nado’ e ‘mergulho’ em um vasto e profundo oceano artístico
Authors: Nascimento Charliston Pablo do 
Published: December 2022

Resumo: O artista francês Jean Cocteau (1889-1963) é comumente interpretado como um surrealista. Todavia, se de fato é possível reconhecer a presença de elementos comuns entre a arte de Cocteau e a abordagem do extraordinário, do inconsciente e do absurdo pelos artistas surrealistas, por outro lado existe uma distinção de natureza e função entre seus respectivos usos. Em Jean Cocteau, o emprego da materialização do irreal, do sonho, do mítico e da ‘lógica do absurdo’ fazem parte não de uma transgressão da realidade sensível, mas da própria identidade existencial e visão de mundo do poeta como um personagem que procura vivenciar e traduzir realidades mais profundas. No presente artigo, procurarei demonstrar: 1) o princípio e unidade da arte multifacetada de Jean Cocteau a partir do conceito de ‘veículos poéticos’; e 2) de que maneira a obra do artista francês nos conduz à necessidade de compreensão, interpretação e experiência de sua arte para além de uma dicotomia entre autoridades epistêmicas, mas, diferentemente, a partir de uma inter-relação entre interpretação de superfície e experiência relacional de profundidade, ao que intitulo crítica de nado e mergulho.
Palavras-chave: Jean Cocteau. Veículos poéticos. Crítica de nado e mergulho.
John Wesley, Eighteenth-Century Medicine, and Health Care for the Poor
Authors: Ott Philip 
Published: December 2022

ABSTRACT:
This article seeks to highlight John Wesley’s commitment to provide health care for the poor. The paucity of health care for the poor was due to several factors, including the scarcity of health care practitioners, hospitals open to upper class or select individuals in particular locations, and the high cost of medicines. This grim picture was compounded by the fact that individuals lacking the necessities of life faced the daily challenge of living out healthy lifestyles. The genius of Wesley is that he took concrete steps to address the issues common to health care in eighteenth-century England. He established a visitation program for the poor followed by his dispensing of medicines to them. In his preface to Primitive Physic, he urged his readers to commit to simple remedies over compound medicines. He also instructed his readers to pursue a life of sensible regimen, a theme constant throughout his ministry.
Metagenre in Paradise Lost and Paradise Regained: Its Relevance to Milton’s Presentation of the Son’s Self-Sacrificial Epic Heroism
Authors: Urban David V. 
Published: December 2022

ABSTRACT
The concept of metagenre in literature has become an increasingly helpful interpretive tool by which to analyze and understand various pieces of literature in relationship to their particular genres. A metageneric examination of Milton’s Paradise Lost and Paradise Regained, both in relation to the Homeric epics and in relation to each other, allows readers to understand that Milton’s celebration of “Patience and Heroic Martyrdom” (Paradise Lost 9:31) is best exemplified in each of Milton’s epics by Milton’s Son. The Son, both in his self-sacrificial decision to leave Heaven’s glory, become incarnate, and die for the sake of sinful humanity; and in his resistance to Satan’s temptations, transcends the classical heroism both of Homer’s Achilles and Milton’s Satan in order to effect salvation for humanity. A metageneric recognition that Paradise Regained is a continuation of Paradise Lost aids greatly our understanding of the Son’s heroism.