bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structure of the pre-mRNA leakage 39-kDa protein reveals a single domain of integrated zf-C3HC and Rsm1 modules
Authors: Hashimoto Hideharu , Ramirez Daniel H. , Lautier Ophélie , Pawlak Natalie , Blobel Günter , Palancade Benoît , Debler Erik W. 
Published: October 2022

AbstractIn Saccharomyces cerevisiae, the pre-mRNA leakage 39-kDa protein (ScPml39) was reported to retain unspliced pre-mRNA prior to export through nuclear pore complexes (NPCs). Pml39 homologs outside the Saccharomycetaceae family are currently unknown, and mechanistic insight into Pml39 function is lacking. Here we determined the crystal structure of ScPml39 at 2.5 Å resolution to facilitate the discovery of orthologs beyond Saccharomycetaceae, e.g. in Schizosaccharomyces pombe or human. The crystal structure revealed integrated zf-C3HC and Rsm1 modules, which are tightly associated through a hydrophobic interface to form a single domain. Both zf-C3HC and Rsm1 modules belong to the Zn-containing BIR (Baculovirus IAP repeat)-like super family, with key residues of the canonical BIR domain being conserved. Features unique to the Pml39 modules refer to the spacing between the Zn-coordinating residues, giving rise to a substantially tilted helix αC in the zf-C3HC and Rsm1 modules, and an extra helix αAB′ in the Rsm1 module. Conservation of key residues responsible for its distinct features identifies S. pombe Rsm1 and Homo sapiens NIPA/ZC3HC1 as structural orthologs of ScPml39. Based on the recent functional characterization of NIPA/ZC3HC1 as a scaffold protein that stabilizes the nuclear basket of the NPC, our data suggest an analogous function of ScPml39 in S. cerevisiae.
Clinical frailty assessment might be associated with mortality in incident dialysis patients
Authors: Oki Rikako , Hamasaki Yoshifumi , Tsuji Shiho , Suzuki Kana , Tsuneishi Sayaka , Imafuku Mikie , Komaru Yohei , Miyamoto Yoshihisa , Matsuura Ryo , Doi Kent , Nangaku Masaomi 
Published: October 2022

AbstractFrailty is associated with mortality in maintenance dialysis patients. For incident dialysis patients, we used the clinical frailty scale (CFS) to investigate frailty as related to mortality or hospitalization within 2 years. We retrospectively reviewed the medical records of patients initiating hemodialysis or peritoneal dialysis during 2016–2018. Based on those records, two dialysis nurses independently used a 9-point CFS (1 = “Very fit” to 9 = “Terminally ill”) to assess each patient’s frailty at dialysis initiation. Patients with a mean CFS value of 5 or higher were classified into the frail group. The 2-year survival rates or hospitalization-free rates after the initiation of dialysis were compared between the frail (mean CFS score ≥ 5) and non-frail (mean CFS score < 5) groups. The analysis included 155 incident dialysis patients with mean age of 66.7 ± 14.1 (71% male). Frailty was inferred for 39 (25%) patients at dialysis initiation. Kaplan–Meier analyses showed that the survival rate and hospitalization-free rate within 2 years were significantly lower in the frail group than in the non-frail group (p < 0.01). Cox proportional hazards regression analyses revealed the CFS score as associated with the occurrence of a composite outcome, independently of age (hazard ratio 1.34, 95% confidence interval 1.04–1.72). Frailty assessment based on clinical judgment using CFS might predict adverse outcomes in dialysis-initiated patients.
Characterization of Pseudoterranova ceticola (Nematoda: Anisakidae) larvae from meso/bathypelagic fishes off Macaronesia (NW Africa waters)
Authors: Bao Miguel , Olsen Kaja M. , Levsen Arne , Cipriani Paolo , Giulietti Lucilla , Storesund Julia E. , García-Seoane Eva , Karlsbakk Egil 
Published: October 2022

AbstractThe genus Pseudoterranova includes parasite species of cetaceans and pinnipeds. The third stage larva (L3) of seal-infecting species occur in second intermediate or paratenic fish hosts mainly in neritic waters. This study firstly describes a Pseudoterranova L3 from meso/bathypelagic fishes off Macaronesia. L3s were morphologically and genetically studied by light microscopy and sequencing of the mtDNA cox2 and entire ITS rDNA genes. Bayesian inferences were performed with sequences from the larvae and selected sequences from GenBank. The nematode L3s were molecularly identified as Pseudoterranova ceticola, a parasite of kogiid whales. Such larvae were collected from Bolinichthys indicus, Chauliodus danae, Eupharynx pelecanoides, Diaphus rafinesquii, D. mollis, Diretmus argenteus and Maulisia argipalla. They mainly occurred in the viscera of these fishes. Pseudoterranova ceticola L3 were small (< 12 mm) and whitish, and a prominent characteristic is a circumoral ridge extending from the ventral boring tooth which differentiate them from Pseudoterranova spp. L3 maturing in pinnipeds and Terranova sensu lato larvae that mature in poikilotherms. The shape of the tail: conical, long, pointed, ventrally curved and lacking mucron also distinguish these larvae from those of the pinniped-infecting Pseudoterranova spp. Phylogenetic analyses based on mtDNA cox2 and ITS rDNA sequences suggest that P. ceticola is closely related to Skrjabinisakis spp., and not with Pseudoterranova spp. parasitizing pinnipeds. The related species Skrjabinisakis paggiae, S. brevispiculata and S. physeteris (until recently belonging to genus Anisakis), are as P. ceticola also parasites of physeteroid cetaceans. The morphology and morphological variation of the larvae of the cetacean parasite P. ceticola is thoroughly described for the first time. These L3 can readily be morphologically distinguished from those of the pinniped-infecting Pseudoterranova spp. The parasite likely completes its life cycle in the mesopelagic and bathypelagic realm, with meso/bathypelagic fish as 2nd intermediate or paratenic hosts and kogiids as final host. Thus, Pseudoterranova from cetaceans appear to be morphologically, genetically, and ecologically differentiated to those from pinnipeds, suggesting that they are not congeneric.
Effectiveness of COVID-19 vaccination in healthcare workers in Shiga Prefecture, Japan
Authors: Chano Tokuhiro , Yamashita Tomoko , Fujimura Hirokazu , Kita Hiroko , Ikemoto Toshiyuki , Kume Shinji , Morita Shin-ya , Suzuki Tomoyuki , Kakuno Fumihiko 
Published: October 2022

AbstractThis study, which included serological and cellular immunity tests, evaluated whether coronavirus disease 2019 (COVID-19) vaccination adequately protected healthcare workers (HCWs) from COVID-19. Serological investigations were conducted among 1600 HCWs (mean ± standard deviation, 7.4 ± 1.4 months after the last COVID-19 vaccination). Anti-SARS-CoV-2 antibodies N-Ig, Spike-Ig (Roche), N-IgG, Spike-IgM, and -IgG (Abbott), were evaluated using a questionnaire of health condition. 161 HCWs were analyzed for cellular immunity using T-SPOT® SARS-CoV-2 kit before, and 52 HCWs were followed up until 138.3 ± 15.7 days after their third vaccination. Spike-IgG value was 954.4 ± 2282.6 AU/mL. Forty-nine of the 1600 HCWs (3.06%) had pre-existing SARS-CoV-2 infection. None of the infectious seropositive HCWs required hospitalization. T-SPOT value was 85.0 ± 84.2 SFU/106 cells before the third vaccination, which increased to 219.4 ± 230.4 SFU/106 cells immediately after, but attenuated later (to 111.1 ± 133.6 SFU/106 cells). Poor counts (< 40 SFU/106 cells) were present in 34.8% and 38.5% of HCWs before and after the third vaccination, respectively. Our findings provide insights into humoral and cellular immune responses to repeated COVID-19 vaccinations. COVID-19 vaccination was effective in protecting HCWs from serious illness during the original Wuhan-1, Alpha, Delta and also ongoing Omicron-predominance periods. However, repeated vaccinations using current vaccine versions may not induce sufficient cellular immunity in all HCWs.
A Mendelian randomization study of genetic predisposition to autoimmune diseases and COVID-19
Authors: Li Shun , Yuan Shuai , Schooling C. M. , Larsson Susanna C. 
Published: October 2022

AbstractAutoimmune diseases and coronavirus disease 2019 (COVID-19) share many similarities. Concerns have arisen that autoimmune diseases may increase the susceptibility and severity of COVID-19. We used Mendelian randomization to investigate whether liability to autoimmune diseases is related to COVID-19 susceptibility and severity. Genetic instruments for 8 autoimmune diseases, including type 1 diabetes mellitus, rheumatoid arthritis, systemic lupus erythematosus, psoriasis, multiple sclerosis, primary sclerosing cholangitis, primary biliary cirrhosis and juvenile idiopathic arthritis, were obtained from published genome-wide association studies. Two-sample Mendelian randomization analyses of the associations of liability to each autoimmune disease with COVID-19 infection, hospitalized COVID-19, and very severe COVID-19 were performed using the latest publicly available genome-wide association study for COVID-19. Genetic liability to each of the autoimmune diseases was largely not associated with COVID-19 infection, hospitalized COVID-19, or very severe COVID-19 after accounting for multiple comparison. Sensitivity analysis excluding genetic variants in the human leukocyte antigen gene, which has an important role in the immune response, showed similar results. The autoimmune diseases examined were largely not genetically associated with the susceptibility or severity of COVID-19. Further investigations are warranted.
Thoracic Limb Angular Deformity in Chondrodystrophic Dogs: Repeatability of Goniometric Measurement of External Rotation and Carpal Valgus
Authors: Pulkkinen Hanna S.M. , Lappalainen Anu K. , Junnila Jouni J.T. , Laitinen-Vapaavuori Outi M. , Hyytiäinen Heli K. 
Published: October 2022

Abstract
Objective We aimed to provide repeatable methods for quantifying antebrachial valgus and rotation in dogs with and without complex angular deformities. Thus, we investigated the repeatability of two methods to measure carpal valgus and one method to measure external rotation of the thoracic limb in a standing position.
Study Design This was a prospective observer agreement study with a sample of 18 non-chondrodystrophic dogs as baseline and 43 chondrodystrophic dogs. The rotation measurements (ROT), modified valgus measurements (VALG-M), and established carpal valgus measurements (VALG) were done independently by two investigators. Repeatability was assessed with intraclass correlation coefficient (ICC).
Results The measured mean (± standard deviation) angles of ROT, VALG-M, and VALG for non-chondrodystrophic dogs were 14 degrees (± 5 degrees), 9 degrees (± 4 degrees), and 4 degrees (± 3 degrees) and 30 degrees (± 13 degrees) and 23 degrees (± 11 degrees) for ROT and VALG-M for chondrodystrophic dogs respectively. In non-chondrodystrophic dogs, ICC was low with mean errors of 1 to 6 degrees, whereas in chondrodystrophic dogs, intra- and intertester ICC was high for ROT and VALG-M with mean errors of 3 to 8 degrees.
Conclusion The ROT and VALG-M methods can be used as reliable tools to objectively quantify aspects of thoracic limb alignment for research, clinical, and screening purposes in both non-chondrodystrophic and chondrodystrophic dogs. The mean values of ROT, VALG-M, and VALG can be used as references for non-chondrodystrophic dogs in the standing position.
Lameness Localization in Dogs: An Exploratory Study of the Translation of the Equine Flexion Test to Canine Orthopaedics
Authors: Grosjean Diane , De Bakker Evelien , Mugnier Amélie , Verschooten Francis , Rytz Ulrich , Forterre Franck , Samoy Yves , Van Ryssen Bernadette 
Published: October 2022

Abstract
Objectives The aim of this study was to describe the method and feasibility of the flexion test (FT) as a diagnostic tool to localize lameness on dogs.
Study Design Canine FT was designed and based on the FT routinely used on horses. In dogs, the test consisted in a flexion of a joint to its full range of motion for 1 minute. Eventual increased lameness was then evaluated. The gait was evaluated using a visual analogue scale. An increase in the lameness score compared with the baseline score was considered as a positive result.The method was described for every major joint of the appendicular skeleton and was evaluated in sound and lame dogs. To evaluate the feasibility, the FT was applied for 3 minutes in eight healthy dogs on all joints. On 27 clinically lame dogs, flexion was applied for 1 minute on the joints with a suspected pathology and on their contralateral side used as a control.
Results The FT was feasible and well tolerated by the sound dogs on all joints and no positive results were recorded. On clinically lame dogs, lameness increased in 81.5% of dogs. These cases were afterwards diagnosed with an orthopaedic-related disorder and then defined as true positives. False negative results occurred in 18.5% of the lameness cases.
Conclusion The FT is safe and easy to perform. It did not produce any false positive results. False negatives might occur in a minor number of cases, implying that a negative result does not exclude a joint pathology.
Stabilization and Long-Term Outcome of a Tibiotarsal Fracture in a Turkey Vulture (Cathartes aura) Using a Supracutaneous Plating Technique
Authors: Liles Marina , Barillo Anthony , Dugat Danielle , Di Girolamo Nicola , Brandão João , Roca Rodrigo 
Published: October 2022

AbstractThe aim of this study was to report the successful outcome of a tibiotarsal fracture in a turkey vulture managed with a supracutaneous plating technique. This is a case report study design. A juvenile male turkey vulture (Cathartes aura) was presented unable to walk. Physical exam revealed instability in the left tibiotarsus. Radiographs confirmed a comminuted mid-diaphyseal fracture of the left tibiotarsus. The turkey vulture underwent fracture stabilization using fluoroscopic guidance with a 12-hole 2.4-mm locking compression plate (LCP) placed in a supracutaneous fashion with locking screws proximally and distally. The turkey vulture was ambulatory immediately following surgery, and lameness had resolved by day three. Four weeks postoperatively, radiographs demonstrated loss of cortical bone density, and the construct was dynamized. At 6 weeks postoperatively, radiographs revealed a bridging callus, and all implants were removed. Following an additional 2 weeks of cage rest, recheck radiographs confirmed continued fracture healing and increased cortical density. At week nine, the turkey vulture was transitioned to a pre-release flight cage where the vulture was noted to set flight, land, grasp, walk, and perch normally. The turkey vulture was released 12 weeks postoperatively. This case report documents the successful functional outcome of a closed, comminuted mid-diaphyseal fracture of the tibiotarsus in a minimally invasive manner utilizing a supracutaneous plating technique. Based on a literature search, this is the first report utilizing supracutaneous plating for a tibiotarsal fracture in a turkey vulture.
Effect of stacking type and magnetic moment in spin-valley polarized MoS2–MoSe2 heterobilayers
Authors: Wu Yanwei , Liu Tao , Hao Ning , Long Mingsheng , Zhang Min , Sun Qingqing , Shan Lei 
Published: October 2022

In this work, we focused on engineering the bandgap of the MoS2–MoSe2 heterobilayer via either stacking type or induced magnetic moment with the aid of density functional theory. We have computed the electronic properties of different stacking MoS2–MoSe2 heterobilayers and their magnetization components, in which all situations retain spin-valley locking. Calculations show that different stacking types can cause a bandgap change of a maximum of 0.1 eV. On the other hand, a micro-enhanced magnetic moment in the heterobilayer increases the bandgap (in some cases, there are changes close to 0.3 eV) significantly. Results suggest that the stacking type and induced magnetic moment make MoS2–MoSe2 heterobilayers potential candidates for valleytronics applications. This study provides a new pathway in tuning spin-valley polarization of valleytronics devices.
Preliminary norms of Arabic to Spanish translations produced by twentieth-century academics
Authors: Feria Manuel , Pérez Cañada Luis M. 
Published: October 2022

Abstract
This article analyzes the preliminary norms (Toury 1995) governing the
translation of Arabic works into Spanish produced by members of Spain’s academic community in the twentieth century. In
particular, we study the ideological motives and objectives behind the choice of works to be translated. Translation was the
ideological tool par excellence of Spanish Arabism. The Catholic Church; Spanish state, regional, and local
government bodies; and the European Cultural Foundation were the principal patrons. The works translated served to endorse the
pre-eminence of Christendom over Islam and to advance Spanish nation-building. They also contributed to the encouragement of
emancipatory and feminist discourses, the commercial success of the Arab winner of the Nobel Prize, Najīb Maḥfūẓ, and the
promulgation among the European public of a discourse opposed to the ‘clash of civilizations’. Thus, our analysis illustrates the
capacity of translation to generate ideology in a specific socio-political context.
Determination of effect of the movement of an infinite fault in viscoelastic half space of standard linear solid using fractional calculus
Authors: Mahato Pabita , Mondal Debabrata , Sarkar (Mondal) Seema 
Published: October 2022

Abstract
The subsurface deformation which is observed in seismic region during aseismic period has a great impact on displacement and stress-strain accumulation due to earthquake fault movement. In this paper we have considered a theoretical model of aseismically creeping, buried, inclined, infinite strike-slip fault located in viscoelastic half space of standard linear-solid medium. Our main objective is to find the analytical solutions of displacement, stresses, strains (a) in the absence of any fault movement and (b) after the commencement of fault movement with the help of Laplace transformation and Green’s function technique using fractional calculus taking Mittag-Leffler function and then to determine numerical results of displacement, stresses and strains with different creep velocities for various inclinations of the fault using suitable model parametric values ([3, 7, 12, 26]). It is observed that the fault in our model exceeds the critical stress at about 117 years if it is a vertical fault while at about 141 years if the fault is inclined at an angle

π

3

with the free surface. A comparative study has been done and the numerical results are found to be in good agreement . This study may help in developing the earthquake prediction program.
Current and future neutrino limits on the abundance of primordial black holes
Authors: Bernal Nicolás , Muñoz-Albornoz Víctor , Palomares-Ruiz Sergio , Villanueva-Domingo Pablo 
Published: October 2022

AbstractPrimordial black holes (PBHs) formed in the early Universe are sources of neutrinos emitted via Hawking radiation. Such astrophysical neutrinos could be detected at Earth and constraints on the abundance of comet-mass PBHs could be derived from the null observation of this neutrino flux. Here, we consider non-rotating PBHs and improve constraints using Super-Kamiokande neutrino data, as well as we perform forecasts for next-generation neutrino (Hyper-Kamiokande, JUNO, DUNE) and dark matter (DARWIN, ARGO) detectors, which we compare. For PBHs less massive than ∼ few × 1014g, PBHs would have already evaporated by now, whereas more massive PBHs would still be present and would constitute a fraction of the dark matter of the Universe. We consider monochromatic and extended (log-normal) mass distributions, and a PBH mass range spanning from 1012g to ∼ 1016g. Finally, we also compare our results with previous ones in the literature.
JINTRAC integrated simulations of ITER scenarios including fuelling and divertor power flux control for H, He and DT plasmas
Authors: Militello Asp E. , Corrigan G. , da Silva Aresta Belo P. , Garzotti L. , Harting D.M. , Köchl F. , Parail V. , Cavinato M. , Loarte A. , Romanelli M. , Sartori R. 
Published: October 2022

Abstract
We have modelled self-consistently how to most efficiently fuel ITER hydrogen (H), helium (He) and deuterium–tritium (DT) plasmas with gas and/or pellets with the integrated core and 2D SOL/divertor suite of codes JINTRAC. This paper presents the first overview of full integrated simulations from core to divertor of ITER scenarios following their evolution from X-point formation, through L-mode, L–H transition, steady-state H-mode, H–L transition and current ramp-down. Our simulations respect all ITER operational limits, maintaining the target power loads below 10 MW m−2 by timely gas fuelling or Ne seeding. For the pre-fusion plasma operation (PFPO) phase our aim was to develop robust scenarios and our simulations show that commissioning and operation of the ITER neutral beam (NB) to full power should be possible in 15 MA/5.3 T L-mode H plasmas with pellet fuelling and 20 MW of ECRH. For He plasmas gas fuelling alone allows access to H-mode at 7.5 MA/2.65 T with 53–73 MW of additional heating, since after application of NB and during the L–H transition, the modelled density build-up quickly reduces the NB shine-through losses to acceptable levels. This should allow the characterisation of ITER H-mode plasmas and the demonstration of ELM control schemes in PFPO-2. In ITER DT plasmas we varied the fuelling and heating schemes to achieve a target fusion gain of Q = 10 and to exit the plasma from such conditions with acceptable divertor loads. The use of pellets in DT can provide a faster increase of the density in L-modes, but it is not essential for unrestricted NB operation due to the lower shine-through losses compared to H. During the H–L transition and current ramp-down, gas fuelling and Ne seeding are required to keep the divertor power loads under the engineering limits but accurate control over radiation is crucial to prevent the plasma becoming thermally unstable.
Forecasting models for carbon dioxide emissions in major economic sectors of Thailand
Authors: Kamoljitprapa P , Sookkhee S 
Published: October 2022

Abstract
The objective of this research is to propose the appropriate forecasting models for the analysis of carbon dioxide emissions classified by major economic sectors in Thailand: the power generation sector, the transportation sector, the industrial sector, and other economic sectors. The twenty years of monthly data from 2001 to 2020 was collected by the Energy Policy and Planning Office, Ministry of Energy. Box-Jenkins ARIMA approach is used to analysed the data in order to obtain the best fit models for each of the economic sectors. Model checking is presented using R2, adjusted-R2 and AIC. The actual data in 2021 was used to illustrate the quality of the optimal forecasting models.
Developing the modified model of thermal comfort
Authors: Dębska L 
Published: October 2022

Abstract
The article discusses human thermal sensations and proposes an improved modification of the Fanger model based on experimental research. The Fanger model was created in the late 1960s and many studies have shown inaccuracies between Predicted Mean Vote (PMV) generated with this model and Thermal Sensation Vote (TSV) obtained in actual tests. 263 people aged 18 to 41 expressed their willingness to test their thermal feelings in selected rooms of the Kielce University of Technology. The questionnaire responses regarding thermal sensations (TSV) and the known body masses index (BMI) of these people clarified the relationship between them. The results of thermal sensation vote (TSV) - actual, as well as the results calculated using the Fanger model -PMV are also shown. The main assumption of the research was to modify the Fanger model in terms of body mass index (BMI). The results have proven that the modification is more accurate than the original model.