bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sequestration and efflux largely account for cadmium and copper resistance in the deep‐sea Nitratiruptor sp. SB155‐2 (phylum Campylobacterota)
Authors: Ares Ángela , Sakai Sanae , Sasaki Toshio , Shimamura Shigeru , Mitarai Satoshi , Nunoura Takuro 
Published: October 2022

AbstractIn deep‐sea hydrothermal vent environments, metal‐enriched fluids and sediments abound, making these habitats ideal to study metal resistance in prokaryotes. In this investigation, we employed transcriptomics and shotgun proteomics with scanning transmission electron microscopy and energy‐dispersive x‐ray spectroscopy (STEM‐EDX) to better understand mechanisms of tolerance for cadmium (Cd) and copper (Cu) at stress‐inducing concentrations in Nitratiruptor sp. SB155‐2 (phylum Campylobacterota). Transcriptomic profiles were remarkably different in the presence of these two metals, displaying 385 (19%) and 629 (31%) differentially transcribed genes (DTG) in the presence of Cd(II) and Cu(II), respectively, while only 7% of differentially transcribed (DT) genes were shared, with genes for non‐specific metal transporters and genes involved in oxidative stress‐response predominating. Transcriptomic and proteomic analyses confirmed that metal‐specific DT pathways under Cu(II) stress, including those involving sulfur, cysteine, and methionine, are likely required for high‐affinity efflux systems, while flagella formation and chemotaxis were over‐represented under Cd(II) stress. Consistent with these differences, STEM‐EDX analysis revealed that polyphosphate‐like granules (pPLG), the formation of CdS particles, and the periplasmic space are crucial for Cd(II) sequestration. Overall, this study provides new insights regarding metal‐specific adaptations of Campylobacterota to deep‐sea hydrothermal vent environments.
Protein regulation mechanism of cold tolerance in Haemaphysalis longicornis
Authors: Wang Ningmei , Ji Aimeng , Masoudi Abolfazl , Li Shuang , Hu Yuhong , Zhang Yefei , Yu Zhijun , Wang Han , Wang Hui , Liu Jingze 
Published: October 2022

AbstractTicks are external parasitic arthropods that can transmit a variety of pathogens by sucking blood. Low‐temperature tolerance is essential for ticks to survive during the cold winter. Exploring the protein regulation mechanism of low‐temperature tolerance of Haemaphysalis longicornis could help to explain how ticks survive in winter. In this study, the quantitative proteomics of several tissues of H. longicornis exposed to low temperature were studied by data independent acquisition technology. Totals of 3 699, 3 422, and 1 958 proteins were identified in the salivary gland, midgut, and ovary, respectively. The proteins involved in energy metabolism, cell signal transduction, protein synthesis and repair, and cytoskeleton synthesis changed under low‐temperature stress. The comprehensive analysis of the protein regulation of multiple tissues of female ticks exposed to low temperature showed that maintaining cell homeostasis, maintaining cell viability, and enhancing cell tolerance were the most important means for ticks to maintain vital signs under low temperature. The expression of proteins involved in and regulating the above cell activities was the key to the survival of ticks under low temperatures. Through the analysis of a large amount of data, we found that the expression levels of arylamine N‐acetyltransferase, inositol polyphosphate multikinase, and dual‐specificity phosphatase were up‐regulated under low temperature. We speculated that they might have important significance in low‐temperature tolerance. Then, we performed RNA interference on the mRNA of these 3 proteins, and the results showed that the ability of female ticks to tolerate low temperatures decreased significantly.
Food safety risk‐assessment systems utilized by China, Australia/New Zealand, Canada, and the United States
Authors: Ng Sieh , Shao Shuyan , Ling Nan 
Published: October 2022

AbstractEnsuring the chemical, physical, and microbial safety of food and ingredients underpins the international trade of food items and is integral to building consumer confidence. Achieving this requires effective systems to support the safety of food across the supply chain. Differing risk‐assessment approaches are utilized globally for establishing food safety systems, and bench marking these approaches against international food safety standards can assist in the development of country‐specific systems. This China–Australia collaborative review examined similarities and differences in the food safety risk‐assessment systems of China, Australia/New Zealand, Canada, and the United States, with the view to identify areas that could support improvements to the Chinese system. Key differences include the level of cohesiveness among stakeholders and the level to which each country promotes the international harmonization of standards. The evidence highlights a need for greater capacity‐building in risk assessment in China that may support greater stakeholders’ cohesion, improve hazard identification, and allow regulators to more readily keep abreast of changes to international standards. This review may help the Chinese food industry to replicate the same level of food safety risk assessment currently applied by other key countries, and reflects the determination, government prioritization, and active strengthening of China's National Centre for Food Safety Risk Assessment currently underway.
Differences in receipt of recommended eye examinations by comorbidity status and healthcare utilization among nonelderly adults with diabetes
Authors: Cai Cindy X. , Kim Minchul , Lundeen Elizabeth A. , Benoit Stephen R. 
Published: October 2022

AbstractBackgroundTo evaluate the effect of diabetes comorbidities by baseline healthcare utilization on receipt of recommended eye examinations.MethodsRetrospective analysis of 310 691 nonelderly adults with type 2 diabetes in the IBM MarketScan Commercial Database from 2016 to 2019. Patients were grouped based on diabetes‐concordant (related) or ‐discordant (unrelated) comorbidities. Logistic regression was used to estimate the prevalence ratio (PR) for eye examinations by comorbidity status, healthcare utilization, and an interaction between comorbidities and utilization, controlling for age, sex, region, and major eye disease.ResultsPrevalence of biennial eye examinations varied by the four comorbidity groups: 43.5% (diabetes only), 52.7% (concordant + discordant comorbidities), 48.0% (concordant comorbidities only), and 45.3% (discordant comorbidities only). In the lowest healthcare utilization tertile, the concordant‐only and concordant + discordant groups had lower prevalence of examinations compared to diabetes only (PR 0.95 [95% CI 0.92–0.98] and PR 0.91 [95% CI 0.88–0.95], respectively). In the medium utilization tertile, the discordant‐only and concordant + discordant groups had lower prevalence of examinations (PR 0.89 [0.83–0.95] and PR 0.94 [0.90–0.98], respectively). In the highest utilization tertile, the concordant‐only and concordant + discordant groups had higher prevalence of examinations.ConclusionsAmong patients with low healthcare utilization, having comorbid conditions is associated with lower prevalence of eye examinations. Among those with medium healthcare utilization, patients with diabetes‐discordant comorbidities are particularly vulnerable. This study highlights populations of diabetes patients who would benefit from increased assistance in receiving vision‐preserving eye examinations.
Foreign Holding Companies and the US Taxation of Foreign Earnings: Evidence from the Tax Increase Prevention and Reconciliation Act of 2005*
Authors: Murphy Frank 
Published: October 2022

ABSTRACTI analyze US multinationals' (MNCs) use of foreign holding companies in their organizational structures and the impact of holding companies on internal capital markets. The look‐thru rule in the Tax Increase Prevention and Reconciliation Act of 2005 (TIPRA) reduces the after‐tax cost of foreign intercompany financing transactions. I use TIPRA as a natural experimental setting to test whether a shift in US tax policy that reduces the cost of moving foreign capital increased firms' reliance on foreign holding company subsidiaries. I find that MNCs responded to TIPRA by creating more foreign holding companies. Furthermore, consistent with the policy objectives of TIPRA, I document that MNCs that rely on holding companies gained tax efficiencies in their post‐TIPRA foreign internal capital markets, reducing domestic taxation on foreign earnings and easing financial constraints. Overall, my results expand our understanding of foreign organizational structure decisions and their internal financing benefits. I contribute to the tax literature by documenting a response to TIPRA that sheds light on the growing complexity of foreign subsidiary ownership structures.
Emplacing capital
Authors: LU VIVIAN CHENXUE 
Published: October 2022

ABSTRACTSince the 1990s, commercial sites across Asia and the Middle East have seen an uptick in visits from Nigerian importers, tens of thousands of whom are now passing through every year. In this context, in which circulatory South–South migration has intensified and transnational commercial links have strengthened, Nigerian mass commercial markets have remained strikingly resistant to monopolies. This is largely shaped by traders’ associations, which defend against corporate and non‐Black foreign actors. This article situates these defensive market practices in longer histories of decolonial “indigenization” efforts, postcolonial anxieties of the petrostate economy, and ethnoregional mobilizations undertaken by Igbo people in Nigeria's post–civil war era. Transnational importers mobilize a distinct politics of “emplacement” in Nigeria, where market actors explicitly attempt to create and control the conditions of exchange. They do so by making political claims to profit and by using the rhetoric of citizenship. [capitalism, emplacement, citizenship, transnational, commerce, Lagos, Nigeria, Africa, Global South]
Remaking the value of work
Authors: FENGJIANG JIAZHI 
Published: October 2022

ABSTRACTIn recent decades China has seen a rise in grassroots “philanthropy” (gongyi), or charity and volunteerism that is not directed by the state. Much of the discussion on this phenomenon suggests that it is a response to a perceived “moral crisis.” But the emergence of grassroots philanthropy is also—and perhaps more centrally—a response to people's changing valuation of work in a time of economic restructuring, especially among people who find their labor at risk of becoming surplus. This development profoundly challenges their sense of self‐worth. As a result, many ordinary people—primarily men with a relatively low social standing—are engaging in philanthropy as a form of “work,” even though this work is frequently in tension with their familial obligations. In doing so, they cocreate alternative social arenas in which the value of their work may be realized. Nonetheless, the question whether doing philanthropy is proper work remains open, ambiguous, and subject to continual negotiation. [grassroots philanthropy,volunteerism,work,value,ethics,China]
Percutaneous needle aspiration versus catheter drainage in the management of liver abscess: an updated systematic review and meta‐analysis
Authors: Al‐Sayaghi Khaled Mohammed , Alhujaily Muhanad , Zaky Mohamed Khaled , Alhasan Ayman S. , Babikir Tamir Bashir , Alnehmi Fawwaz Saleh , Abdalrahman Hager Hassan , Abdelmalik Mohammed Abdelkrim Adam , Ali Adel Mohamed , Fadlalmola Hammad Ali , Swamy D. S. Veerabhadra 
Published: October 2022

AbstractBackgroundLiver abscesses differ in their aetiology, location, and number. Image‐guided percutaneous drainage techniques are the currently used management for liver abscesses. We conducted our study to compare the clinical safety and efficacy of percutaneous needle aspiration (PNA) to percutaneous catheter drainage (PCD).MethodsA systematic review of major reference databases was undertaken in February 2022 for randomized controlled trials (RCTs) that compare PNA to PCD in treating liver abscess patients. The quality of the included trials was assessed using the Cochrane tool. Statistical meta‐analysis was conducted using RevMan and open meta‐analyst software.ResultsFifteen RCTs were included in this review, with 1676 patients enrolled. The overall quality of the included trials was moderate, with most domains of unclear risk. PCD was superior to PNA in the success rate (RR = 1.23; 95% CI [1.12, 1.36], P < 0.00001), time for achieving 50% reduction of cavity size (MD = −2.32; 95% CI [−3.07, −1.57], P < 0.00001), and time for clinical improvement (MD = −1.92; 95% CI [−2.55, −1.28], P < 0.00001). The two modalities did not differ in the days of hospital stay, duration of IV antibiotics, and time needed for total or subtotal reduction of cavity size (P = 0.36, P = 0.06 and P = 0.40, respectively). High heterogeneity levels were detected. Regarding major complications, the two modalities were equally safe (P = 0.39).ConclusionPCD has a higher success rate and results in a faster 50% reduction in the abscess cavity size and clinical improvement. The two modalities are equally safe.
Generation of glucose sensitive insulin‐secreting cells from human induced pluripotent stem cells on optimized polyethersulfone hybrid nanofibrous scaffold
Authors: Ahmadi Seyedeh Fatemeh , Mansour Reyhaneh Nassiri , Hassannia Hadi , Enderami Seyed Ehsan , Abediankenari Saeid , Hosseini‐khah Zahra 
Published: October 2022

AbstractBackgroundIn the realm of diabetes treatment, various strategies have been tried, including islet transplantation and common drug therapies, but the limitations of these procedures and lack of responsive to the high number of patients have prompted researchers to develop a new method. In recent decades, the use of stem cells and three‐dimonsional (3D) scaffold to produce insulin‐secreting cells is one of the most promising new approaches. Meanwhile, human‐induced pluripotent stem cells (iPSCs) propose due to advantages such as autologousness and high pluripotency in cell therapy. This study aimed to evaluate the differentiation of iPSCs into pancreatic islet insuli‐producing cells (IPCs) on Silk/PES (polyethersulfone) nanofibers as a 3D scaffold and compare it with a two‐dimonsional (2D) cultured group.MethodsInvestigating the functional, morphological, molecular, and cellular characteristics of differentiated iPSCs on control cultures (without differentiation medium), 2D and 3D were measured by various methods such as electron microscopy, Q‐PCR, immunofluorescence, western blot, and ELISA.ResultsThis investigation revealed that differentiated cells on the 3D Silk/PES scaffold expressed pancreatic specific‐markers such as insulin and pdx1 at higher levels than the control and 2D groups, with a significant difference between the two groups. All results of Q‐PCR, immunocytochemistry, and western blot showed that IPCs in the silk/PES 3D group was more efficient than in the 2D group. In the face of these cases, the release of insulin and C‐peptide in response to several concentrations of glucose in the 3D group was significantly higher than in the 2D culture.ConclusionFinally, our findings displayed that optimized Silk/PES 3D scaffolds can enhance the differentiation of IPCs from iPSCs compared to the 2D culture group.
Incidence of heart failure following exposure to a protein kinase inhibitor, a French population‐based study
Authors: Zelmat Yoann , Conte Cécile , Noize Pernelle , Vabre Clémentine , Pajiep Marie , Lafaurie Margaux , Lapeyre‐Mestre Maryse , Despas Fabien 
Published: October 2022

AimsPharmacovigilance signals of heart failure (HF) following exposure to protein kinase inhibitors (PKIs) have been detected in recent years. Our aim was to identify the PKIs most frequently associated with the development of HF.MethodsUsing the French National Healthcare Database, all patients newly exposed to a PKI between January 2011 and June 2014 were followed up for 18 months. Specific hospitalization diagnosis and long‐term HF‐related disease codes were used to identify HF patients. HF incidence rate ratios (IRRs) were measured and adjusted hazard ratios (aHRs) were estimated using a Cox model. Sensitivity analyses were performed to limit the potential indication and competitive risk bias.ResultsThirteen PKIs were studied. Among the 49 714 new PKI users registered during the study period, the mean IRR of HF was 3.38 per 100 person‐years, with a median time to onset of 155 days. We found a significant increase in the incidence of HF for six medicinal products: pazopanib (aHR = 2.42, 95% confidence interval [CI] 1.67‐3.52), dasatinib (aHR = 2.22, 95% CI 1.42‐3.44), ruxolitinib (aHR = 2.11, 95% CI 1.69‐2.64), crizotinib (aHR = 1.71, 95% CI 1.07‐2.72), everolimus (aHR = 1.45, 95% CI 1.26‐1.67) and vemurafenib (aHR = 1.37, 95% CI 1.01‐1.86). Sensitivity analyses were consistent with our primary analysis.ConclusionsThe current study provides knowledge on HF following exposure to a PKI. Additional studies could confirm these results for dasatinib, everolimus, pazopanib and ruxolitinib, and particularly for the two medicinal products with results slightly above the significance threshold, namely, crizotinib and vemurafenib, in our sensitivity analyses.
Breech specialist midwives and clinics in the OptiBreech Trial feasibility study: An implementation process evaluation
Authors: Dasgupta Tisha , Hunter Sarah , Reid Sharna , Sandall Jane , Shennan Andrew , Davies Siân M. , Walker Shawn 
Published: October 2022

AbstractBackgroundAttendance of skilled and experienced professionals at breech births has been associated with a reduction in adverse perinatal outcomes. We aimed to determine whether United Kingdom National Health Service (NHS) sites could reliably provide attendants with OptiBreech training and/or advanced proficiency (intervention feasibility) and consistent care (fidelity) that meets women's needs (acceptability), with low neonatal admission rates (safety) and recruitment adequate to support a clinical trial (trial feasibility).MethodsMixed methods implementation evaluation was used. Settings were 13 services in England and Wales. Participants were 82 women requesting support for a vaginal breech birth (VBB) at term. Outcomes were descriptively analyzed. Twenty‐one women were interviewed, and transcripts were analyzed using the Theoretical Framework of Acceptability. Iterative analysis informed subsequent interviews and the ongoing process of implementation across sites.ResultsAlthough we initially suggested multidisciplinary teams, actively recruiting Trusts yielded services where VBB care was provided through a dedicated clinic, organized and delivered primarily by a lead midwife who functioned as a specialist. This model achieved 87.5% fidelity with the intervention's goal of ensuring the attendance of OptiBreech‐trained professionals. Neonatal outcomes remained stable, with an admission rate of 5.5%. Women reported care from specialist midwives as highly acceptable, but the model is vulnerable without a strategic effort to develop additional proficient team members.ConclusionsDedicated clinics coordinated by specialist midwives appear to be an acceptable and feasible implementation strategy to test the safety and effectiveness of proficient team care for VBB in a clinical trial. Back‐up arrangements should be maintained while additional members of the team develop proficiency.
Large lending and banks performance. Is there any relationship? Empirical evidence from US banks
Authors: Andriakopoulos Konstantinos , Kounetas Konstantinos 
Published: October 2022

AbstractLarge lending in the banking industry has sparked concerns about banks’ efficiency performance, particularly, if it is related to their credit risk, as trade credit, provided by large, creditworthy firms. We provide evidence of a rather neglected issue regarding the impact of large lending on banks’ efficiency using cost and profit stochastic functions. A unique dataset was constructed concerning all US banks collected from the Statistics on Depository Institutions report compiled by the Federal Deposit Insurance Corporation. Our sample contains US banks tracked yearly for the period 2010–2017, creating an unbalanced panel of year observations. An econometric framework based on nested non‐neutral frontiers was developed to estimate the influence and the decomposition of large lending on the three banks’ performance aspects. Moreover, different types of frontiers aiming at the cost and profit sides have been investigated, and the associated elasticities have been calculated. We notice that large lending plays a crucial role in banks’ technical efficiency. Variations among different frontier models, type of bank and size, banks’ ownership structure, and macroeconomic conditions appear to be present. By considering all capital adequacy asset quality management earnings liquidity parameters, we notice that banks’ financial strength affects banks’ efficiency.
S‐1 eliminates MDSCs and enhances the efficacy of PD‐1 blockade via regulation of tumor‐derived Bv8 and S100A8 in thoracic tumor
Authors: Nguyen Na T. , Mitsuhashi Atsushi , Ogino Hirokazu , Kozai Hiroyuki , Yoneda Hiroto , Afroj Tania , Sato Seidai , Nokihara Hiroshi , Shinohara Tsutomu , Nishioka Yasuhiko 
Published: October 2022

AbstractMyeloid‐derived suppressor cells (MDSCs) have been known to play a pivotal role in the induction of immune tolerance, which limits the benefits of immune checkpoint inhibitors (ICIs). Recent studies revealed that several chemotherapeutic agents decreased tumor‐infiltrating MDSCs. Therefore, combination therapy with cytotoxic chemotherapeutic agents and ICIs was approved for first‐line treatment for lung cancer. However, the impact of chemotherapeutic agents on MDSCs and an optimal partner of ICIs has not been fully investigated in thoracic tumors, including lung cancer and malignant pleural mesothelioma. In the present study, we found that treatment with 5‐FU and its oral formulation, S‐1, suppressed tumor progression and inhibited the accumulation of MDSCs in thoracic tumor‐bearing mice. Tumor‐infiltrating T cells and dendritic cells were significantly expanded in S‐1‐treated mice. 5‐FU suppressed the ability of tumor cells to recruit MDSCs, while it did not suppress the survival and differentiation of mouse MDSCs in vitro. We also revealed that 5‐FU or S‐1 significantly downregulated the expression of tumor‐derived Bv8 and S100A8. The knockdown of Bv8 or S100A8 in tumor cells suppressed tumor growth and MDSC recruitment in vivo. Furthermore, in comparison with pemetrexed, administration of S‐1 improved the synergistic therapeutic efficacy of anti‐PD‐1 antibodies with or without carboplatin. Our findings revealed a novel mechanism wherein S‐1 primed a favorable tumor microenvironment to provide the rationale for combination therapy with S‐1 and ICIs as the optimal therapy for thoracic cancer.