bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial-Temporal Trends in Ovarian Cancer Outcomes in California
Authors: Villanueva Carolina , Chang Jenny , Ziogas Argyrios , Bristow Robert E , Vieira Verónica M 
Published: October 2022

Abstract

Background
Research suggests that geographic location may affect ovarian cancer (OC) outcomes. Insurance status often remains an important predictor of outcomes. The Affordable Care Act was enacted in 2010 to expand access to affordable health insurance. Our objective was to examine spatiotemporal trends in OC treatment nonadherence and disease-specific mortality in California (USA) among women diagnosed with OC.

Methods
Newly diagnosed epithelial OC cases between 1996 and 2017 were identified from the California Cancer Registry. Spatiotemporal trends in adherence to treatment guidelines were examined using generalized additive models and OC-specific mortality using Cox proportional hazards additive models. Prediction grids covering California were used to display the odds ratios (ORs) and hazard ratios of location using the median value for the study area as the referent value. Seven overlapping 5-year periods and 2 larger ones (pre- and post-2013) were assessed. Analyses were stratified according to stage (early vs advanced) and used P = .05 to determine statistical significance.

Results
Statistically significant spatial patterns in treatment nonadherence were observed for every time period examined (P &lt; .001). Odds of treatment nonadherence associated with geographic location were highest among women with early-stage OC in southern Los Angeles County during 2014-2017 (OR max = 3.89, confidence interval = 1.04 to 7.61). For women with advanced-stage OC, residing in northern California was generally associated with lower odds ratios, whereas southern California was associated with higher odds ratios, with higher odds in the latter time period (OR range = 0.53-1.84 in 1996-2012 vs 0.49-2.37 in 2013-2017). Geographic location was not a statistically significant predictor of mortality.

Conclusions
Residential location was statistically significantly associated with treatment received in California, with spatial patterns varying over time but not OC-specific mortality. Changes in insurance status over time were accompanied by shifts in population demographics and increased travel distances to receive care.
INRI-seq enables global cell-free analysis of translation initiation and off-target effects of antisense inhibitors
Authors: Hör Jens , Jung Jakob , Ðurica-Mitić Svetlana , Barquist Lars , Vogel Jörg 
Published: October 2022

AbstractRibosome profiling (Ribo-seq) is a powerful method for the transcriptome-wide assessment of protein synthesis rates and the study of translational control mechanisms. Yet, Ribo-seq also has limitations. These include difficulties with the analysis of translation-modulating molecules such as antibiotics, which are often toxic or challenging to deliver into living cells. Here, we have developed in vitro Ribo-seq (INRI-seq), a cell-free method to analyze the translational landscape of a fully customizable synthetic transcriptome. Using Escherichia coli as an example, we show how INRI-seq can be used to analyze the translation initiation sites of a transcriptome of interest. We also study the global impact of direct translation inhibition by antisense peptide nucleic acid (PNA) to analyze PNA off-target effects. Overall, INRI-seq presents a scalable, sensitive method to study translation initiation in a transcriptome-wide manner without the potentially confounding effects of extracting ribosomes from living cells.
Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions
Authors: Miller Julie J , Gonzalez Castro L Nicolas , McBrayer Samuel , Weller Michael , Cloughesy Timothy , Portnow Jana , Andronesi Ovidiu , Barnholtz-Sloan Jill S , Baumert Brigitta G , Berger Mitchell S , Bi Wenya Linda , Bindra Ranjit , Cahill Daniel P , Chang Susan M , Costello Joseph F , Horbinski Craig , Huang Raymond Y , Jenkins Robert B , Ligon Keith L , Mellinghoff Ingo K , Nabors L Burt , Platten Michael , Reardon David A , Shi Diana D , Schiff David , Wick Wolfgang , Yan Hai , von Deimling Andreas , van den Bent Martin , Kaelin William G , Wen Patrick Y 
Published: October 2022

Abstract
Isocitrate dehydrogenase (IDH) mutant gliomas are the most common adult, malignant primary brain tumors diagnosed in patients younger than 50, constituting an important cause of morbidity and mortality. In recent years, there has been significant progress in understanding the molecular pathogenesis and biology of these tumors, sparking multiple efforts to improve their diagnosis and treatment. In this consensus review from the Society for Neuro-Oncology (SNO), the current diagnosis and management of IDH-mutant gliomas will be discussed. In addition, novel therapies, such as targeted molecular therapies and immunotherapies, will be reviewed. Current challenges and future directions for research will be discussed.
Keeping Company
Authors: Kearney Amanda 
Published: October 2022

Abstract
This chapter considers the principle of “keeping company” as a praxis of companionship, rights and responsibility that defines many Indigenous people’s relationships to their Country, language, Law and other cultural expressions. Keeping company involves a relational complementarity, and invokes principles of the communal and interconnected, over the individual or atomized visions of social and cultural life. This discussion is directly inspired by ethnographic insights gained in working with Yanyuwa, the Indigenous owners of lands and waters in the southwest Gulf of Carpentaria, Northern Territory, Australia. Keeping company is one of the ways that Yanyuwa create relational links to one another, to their ancestors, to places, to their heritage, and to nonhuman species. By broadening the ontology of relating, keeping company is taken as the inspiration for reflection on a more expansive field of possibilities in how people interact with and care for their Country as replete with the legacy and influence of their ancestors and old people (a term given to both present day elders and deceased kin). This has bearing on the way that cultural expressions are understood and safeguarded as part of an everyday relational praxis that ensures Indigenous people’s connections to one another, as well as their Law and Country.
Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV-2 vaccination
Authors: Gumber Leher , Gomez Nancy , Hopkins Georgina , Tucis Davis , Bartlett Laura , Ayling Kieran , Vedhara Kavita , Steers Graham , Chakravorty Mithun , Rutter Megan , Jackson Hannah , Tighe Patrick , Ferraro Alastair , Power Sheila , Pradère Marie-Josèphe , Onion David , Lanyon Peter C , Pearce Fiona A , Fairclough Lucy 
Published: October 2022

Abstract

Objectives
Coronavirus 2019 vaccine responses in rare autoimmune rheumatic diseases (RAIRDs) remain poorly understood; in particular there is little known about whether people develop effective T cell responses. We conducted an observational study to evaluate the short-term humoral and cell-mediated T cell response after the second severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination in RAIRD patients compared with healthy controls (HCs).

Methods
Blood samples were collected after the second dose and anti-spike, anti-nucleocapsid antibody levels and SARS-CoV-2-specific T cell responses were measured and compared with those of HCs. Activation-induced marker and deep phenotyping assays were used to identify differences in T cells between high and no/low antibody groups, followed by multidimensional clustering.

Results
A total of 50 patients with RAIRDs were included (31 with AAV, 4 with other systemic vasculitis, 9 with SLE and 6 with myositis). The median anti-spike levels were significantly lower in RAIRD patients compared with HCs (P &lt; 0.0001). Fifteen (33%) patients had undetectable levels and 26 (57%) had levels lower than the lowest HC. Rituximab in the last 12 months (P = 0.003) was associated with reduced immunogenicity compared with a longer pre-vaccination period. There was a significant difference in B cell percentages (P = 0.03) and spike-specific CD4+ T cells (P = 0.02) between no/low antibody vs high antibody groups. Patients in the no/low antibody group had a higher percentage of terminally differentiated (exhausted) T cells.

Conclusions
Following two doses, most RAIRD patients have lower antibody levels than the lowest HC and lower anti-spike T cells. RAIRD patients with no/low antibodies have diminished numbers and poor quality of memory T cells that lack proliferative and functional capacities.
Development of a Primary Palliative Nursing Care Competence Model and Assessment Tool: A Mixed-Methods Study
Authors: Lippe Megan P. , Davis Andra 
Published: October 2022

Abstract

AIM
The purpose of this study was to develop a new primary palliative nursing care (PPNC) competence model and assessment tool.

BACKGROUND
Consensus guidelines, a national position statement, and new nursing program accreditation standards require nurses to be educated in providing PPNC. A means to assess PPNC competence for prelicensure nursing students and entry-level nurses is needed.

METHOD
The mixed-methods study utilized a three-phase design encompassing in-depth document analysis and expert workgroups; focus groups with palliative care educators, practitioners, and administrators; and stakeholder focus groups.

RESULTS
Findings across all phases resulted in development of a PPNC competence model and assessment tool, each composed of nine domains and associated competency statements.

CONCLUSION
There is a global imperative for nurses to provide high-quality PPNC. Both the model and assessment tool are vital to develop a nursing workforce with the skills to care for persons with serious illness and their families.
Alternative Clinical Learning Experiences for Nursing Education Using Virtual Individual Patients
Authors: Kubin Laura , Fogg Niki , Trinka Michele 
Published: October 2022

Abstract
Acute care pediatric clinical experiences for undergraduate nursing students can present a challenge given the limited availability of clinical sites, increased restrictions, and variations in direct patient care experiences. Unfolding virtual individual patient pediatric simulations were developed using complex pediatric disorders with multiple physiological, psychosocial, and developmental components. Ten unfolding simulations were implemented to standardize clinical experiences and replace clinical hours. Students were evaluated using the Quint Leveled Clinical Competency Tool, demonstrating overall progressing ability to use clinical reasoning skills. Unfolding virtual individual patients allow for deliberate, coordinated, and consistent exposure to clinical experiences and are a valuable substitution for traditional clinicals.
Alarming trends and disparities in high-risk endometrial cancer
Authors: Eakin Cortney M. , Lai Tiffany , Cohen Joshua G. 
Published: October 2022

Purpose of review
To summarize the most recent publications highlighting the trends and disparities among patients diagnosed with high-risk endometrial cancer.

Recent findings
Endometrial cancer mortality continues to rise, driven by the increasing incidence of high-risk histologic subtypes that accounts for a disproportionate number of endometrial cancer deaths. The lack of progress made in endometrial cancer treatment, particularly of high-risk histologic subtypes, disproportionately affects black women who are more likely to be diagnosed with these aggressive tumor types. Even when accounting for high-risk histology, various factors across the spectrum of care may influence the survival disparities between black and white women, including timely access to guideline-concordant care, clinical trial enrollment, and systemic racism that impacts cancer outcomes.

Summary
In this review, we highlight the disproportionate impact of worsening endometrial cancer mortality and healthcare inequalities contributing to the endometrial cancer survival disparity between black and white women.
Progression of Myopic Maculopathy: A Systematic Review and Meta-Analysis
Authors: Itoi Motohiro , Hieda Osamu , Kusada Natsuki , Miyatani Takafumi , Kojima Kentaro , Sotozono Chie 
Published: October 2022

Purpose:
The purpose of this study was to elucidate the risk factors for the progression of myopic maculopathy (MM) based on severity.

Methods:
In this study, we conducted a systematic review and meta-analysis of the literature published before December 2020 on the risk factors for the progression of MM in patients with pathologic myopia (PM) and high myopia (HM). Odds ratios (ORs) for different stages of myopic maculopathy categorized based on the International Meta-Analysis for PM (META-PM) classification were calculated using fixed and random effects models.

Results:
A total of 12,070 affected eyes derived from 5 cohort studies were included in the systematic review. The presence of PM at baseline was found to be significantly associated with an increased risk of MM progression (pooled ORs: 7.17, 95% confidence interval [CI]: 3.29–15.6), and the greater category of MM at baseline was found to be significantly associated with an increased risk of MM progression, that is, eyes with MM category 3 or more compared with eyes with MM category 2 (pooled OR: 10.95, 95% CI: 6.07–19.76) and eyes with MM category 4 compared with eyes with MM category 3 (pooled ORs: 2.45, 95% CI: 0.28–21.37).

Conclusions:
The findings in this systematic review and meta-analysis indicate that the progression of MM is associated with more severe MM at baseline.
Accuracy of neuropathic pain measurements in patients with symptoms of polyneuropathy: validation of painDETECT, Self-Completed Leeds Assessment of Neuropathic Symptoms and Signs, and Douleur Neuropathique 4
Authors: Dunker Øystein , Grotle Margreth , Bu Kvaløy Marie , Uglem Martin , Løseth Sissel , Hjelland Ina Elen , Kleggetveit Inge Petter , Allen Sara Maria , Dehli Vigeland Maria , Munk Killingmo Rikke , Sand Trond , Nilsen Kristian Bernhard 
Published: October 2022

Abstract
Pain is a common symptom in patients referred to polyneuropathy assessment. Diagnostic evaluation and choice of treatment may depend on whether the pain is likely to be neuropathic or not. This study aimed to investigate the diagnostic accuracy of 3 tools commonly used to differentiate between neuropathic and nonneuropathic pain. To accomplish this, we included patients with bilateral distal lower extremity pain, referred to neurological outpatient clinics at 5 Norwegian University hospitals for polyneuropathy assessment. The patients filled in Norwegian versions of painDETECT, the Self-Completed Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS), and the clinician-rated Douleur Neuropathique 4 (DN4). All patients underwent a clinical examination and nerve conduction measurements and were classified according to the NeuPSIG neuropathic pain criteria (reference standard). In total, 729 patients were included, of which 63% had neuropathic pain by the reference standard. Only DN4 demonstrated high sensitivity (0.87), whereas all 3 tools had low specificity (≤0.65). Importantly, the tools' predictive ability was unsatisfactory; The probability of getting a correct test result was 3 quarters at best, and at worst, no better than two fifths. Consequently, we show that neither DN4, painDETECT, nor S-LANSS can be confidently used to assess neuropathic pain in a neurological outpatient population with symptoms of polyneuropathy.
Decrease in Health-Related Quality of Life and Post–COVID-19 Syndrome in Health Care Workers After SARS-CoV-2 Infection
Authors: D'Ávila Karen Gomes , Monaiar Luciana Rott , Dantas Lia Dias Pinheiro , Freitas Alana Ambos , Loureiro Marcelle Martinez , Bonamigo Renan Rangel , Dantas Filho Fábio Fernandes , Silva Denise Rossato 
Published: October 2022

Objectives
The aim of this study is to assess the persistence of symptoms, the prevalence of post–COVID-19 syndrome, and the health-related quality of life (HRQOL) among health care workers (HCWs) 6 months after severe acute respiratory syndrome coronavirus 2 infection.

Methods
A prospective cohort study was conducted. All HCWs with confirmed COVID-19 from January to June 2021 were invited to participate. Health-related quality of life was evaluated in three moments: before COVID-19, after COVID-19 (on return to work), and after 6 months. Persistence of symptoms post–COVID-19 was also assessed.

Results
There was a worsening in all dimensions of HRQOL. After 6 months, self-rated health on EuroQol visual analog scale did not return to pre–COVID-19 values. At total, 36.2% of HCWs were diagnosed with post–COVID-19 syndrome.

Conclusions
There was a significant deterioration in HRQOL among HCWs who had COVID-19 and a high frequency of post–COVID-19 syndrome.
What Personal and Work-Related Characteristics of Dutch Construction Workers With Knee Osteoarthritis Are Associated With Future Work Ability?
Authors: De Kock Britte L. , Van der Gragt Jack , Van der Molen Henk F. , Kuijer P. Paul F.M. , Zipfel Nina 
Published: October 2022

Objective
To assess personal and work-related characteristics of construction workers with knee osteoarthritis (KO) associated with their ability to perform their current profession in the following 2 years.

Methods
A cross-sectional study was performed among Dutch construction workers diagnosed with KO using data from the Worker Health Surveillance. Logistic regression was used to assess the characteristics associated with future work ability.

Results
On the basis of 344 construction workers with KO, being able to perform their current profession in 2 years' time was associated with working weekly 36 to 45 hours (odds ratio [OR], 3.0 to 6.3), performing high-intensity exercises 1 to 2 times weekly (OR, 2.0 to 2.6), being younger than 56 years (OR, 0.2 to 0.3), and not performing strenuous work activities such as lifting and kneeling (OR, 0.4 to 0.5).

Conclusions
To keep construction workers with KO at work, intervention studies should evaluate the effects of reducing strenuous work activities and promote leisure-time exercise.
Safety and Effectiveness of Veno-Venous Extracorporeal Membrane Oxygenation Combined With Continuous Renal Replacement Therapy
Authors: Ferrari Fiorenza , Manera Miriam , Villa Gianluca , De Silvestri Annalisa , Bianchi Bosisio Nicholas Simone Manuel , Guglielmi Angelo , Mazza Giovanni , Colombo Costanza , D’Auria Luigi , Rampino Teresa , Belliato Mirko 
Published: October 2022

Patients receiving extracorporeal membrane oxygenation (ECMO) often suffer from acute kidney injury (AKI), requiring continuous renal replacement therapy (CRRT). In our clinical practice, we connected the inlet line of a CRRT machine to the postoxygenator Luer port and the outlet line to the inlet Luer port of the oxygenator. In this case series, we analyzed the interaction between the two machines. Between December 31, 2017, and December 31, 2019, we enrolled 15 patients from the ICU of the San Matteo Hospital, Pavia, Italy. All of them suffered from severe acute respiratory distress syndrome and AKI stage 3. We analyzed 570 hours of CRRT combined with venovenous ECMO and collected 261,751 CRRT data. No discontinuation of CRRT occurred before 48 hours. Most of the alarms occurred within 24 hours of the connection: 22/10,831 (0.2%) showed an outranged inlet pressure, 11/10831 (0.11%) showed an outranged transmembrane pressure, 14/10,831 (0.13%) showed an outranged inlet pressure, and 138/10,831 (1.27%) an outranged effluent pressure.
The rate per minute set for the ECMO circuit was correlated with the inlet (β = 5.38; CI, 95% 1.42–9.35; p = 0.008), transmembrane (β = 4.6; CI, 95% 1.97–7.24; p = 0.001), effluent (β = 3.02; CI, 95% 1.15–4.90; p = 0.002), and outlet pressures (β = 597; CI, 95% 2.31–9.63; p = 0.001) of the CRRT circuit. We reported that our configuration could be safe and effective, however well-designed studies would be beneficial for determining the potential risks and benefits.
Who should be referred for a CT coronary calcium score? Introducing a simple patient risk questionnaire combining traditional and novel risk factors
Authors: Fenton Stephen M. , Arora Millie , Gransar Heidi , Berman Daniel S. , Wong Nathan D. 
Published: October 2022

Background
Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of death. Coronary artery calcium (CAC) strongly predicts the risk of ASCVD. There is a need to know who would benefit most from CAC scanning.

Objectives
We examined the utility of a new, simple, easy-to-use, and interactive patient risk questionnaire (PRQ), incorporating both traditional and non-traditional risk factors to identify those most likely to benefit from CAC scanning.

Methods
Data from the EISNER Study was used to study the PRQ in relation to the extent of CAC and whether it added incremental value over the Pooled Cohort Risk Score (PCRS) for identifying CAC.

Results
Among 1332 participants a mean PRQ score of 5.6 ± 1.7 was obtained. Negative scans ranged from 95.5% for PRQ scores of 0–1 to only 32.5% for those with a PRQ score of 8. A PRQ score of 3 or more was shown to be associated with a 54% prevalence of CAC. The frequency of a CAC score >=100 was 0 with PRQ = 0–1 and 36% in patients with PRQ = 8. The cNRI of the PRQ score over the PCRS in predicting the presence of CAC was 0.20 (95% CI, 0.09– 0.30; P = 0.0004), mainly due to down-stratifying risk

Conclusions
A unique and simple PRQ identifies those most likely to have a positive CAC scan and may be useful to predict who will benefit most from CAC scanning, allowing for its use in those patients who are most appropriate.