bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Dual‐Kinetic Control Strategy for Designing Nano‐Metamaterials: Novel Class of Metamaterials with Both Characteristic and Whole Sizes of Nanoscale
Authors: Xu Guanhua , Li Mengmeng , Wang Qiyue , Feng Feng , Lou Qi , Hou Yi , Hui Junfeng , Zhang Peisen , Wang Li , Yao Li , Qin Shijie , Ouyang Xiaoping , Wu Dazhuan , Ling Daishun , Wang Xiuyu 
Published: November 2022

AbstractIncreasingly intricate in their multilevel multiscale microarchitecture, metamaterials with unique physical properties are challenging the inherent constraints of natural materials. Their applicability in the nanomedicine field still suffers because nanomedicine requires a maximum size of tens to hundreds of nanometers; however, this size scale has not been achieved in metamaterials. Therefore, “nano‐metamaterials,” a novel class of metamaterials, are introduced, which are rationally designed materials with multilevel microarchitectures and both characteristic sizes and whole sizes at the nanoscale, investing in themselves remarkably unique and significantly enhanced material properties as compared with conventional nanomaterials. Microarchitectural regulation through conventional thermodynamic strategy is limited since the thermodynamic process relies on the frequency‐dependent effective temperature, Teff(ω), which limits the architectural regulation freedom degree. Here, a novel dual‐kinetic control strategy is designed to fabricate nano‐metamaterials by freezing a high‐free energy state in a Teff(ω)‐constant system, where two independent dynamic processes, non‐solvent induced block copolymer (BCP) self‐assembly and osmotically driven self‐emulsification, are regulated simultaneously. Fe3+‐“onion‐like core@porous corona” (Fe3+‐OCPCs) nanoparticles (the products) have not only architectural complexity, porous corona and an onion‐like core but also compositional complexity, Fe3+ chelating BCP assemblies. Furthermore, by using Fe3+‐OCPCs as a model material, a microstructure‐biological performance relationship is manifested in nano‐metamaterials.
Validation of the Black Community Activism Orientation Scale with racially and ethnically diverse college students
Authors: Hope Elan C. , Kornbluh Mariah , Hagan Melissa , Davis Amanda L. , Alexander Anitra 
Published: November 2022

AbstractThis study fills a methodological gap in racial justice research by assessing the utility and validity of the Black Community Activism Orientation Scale (BCAOS) in a racially and ethnically diverse sample of college‐going young adults (N = 624, M = 19.4 years, SD = 1.89) from 10 colleges in the United States. Confirmatory factor analysis was conducted to estimate the goodness of fit of the proposed three‐factor model and assess the validity of the BCAOS. Findings from the confirmatory factor analysis provide statistical support for use of the BCAOS as a measure of racial justice activism in support of Black communities among racially and ethnically diverse college‐going young adults. Findings from the study also suggest that White college students and men are less oriented toward racial justice activism than women and racially marginalized students. Convergent and discriminant validity were established through bivariate correlations of the BCAOS factors with other civic development measures. As more and more young people consider the importance of standing against racial oppression, the BCAOS has utility as an assessment instrument in future racial justice research, education, intervention, and youth programming efforts.
A highly loaded, excellent recyclable nanosheet catalyst Au@mesoporous SiO2
Authors: Zhang Qun , Xu Hongbo , Pan Lei , Kuchmizhak Aleksandr , Wang Lei 
Published: November 2022

Gold@mesoporous silica nanosheet (Au@MSNS) catalyst was synthesized by one‐pot reduction of HAuCl4 with formaldehyde. Subsequent SiO2 recoating procedure was shown to reduce the average size of the loading Au nanoparticles, resulting in significantly improved catalytic activity of the modified Au@MSNSs against reduction of 4‐nitrophenol. Moreover, this procedure improves mechanical properties and reusability of the catalyst demonstrating superior turnover frequency of 91.954 × 10−3 mol g−1 h−1 in cyclic reaction.
Fabrication of Ru/Ir doped TiO2 electrode for electrocatalytic degradation of phenol
Authors: Ren Qiaolin , Yang Ruirui , Li Junying , Yan Wenjun , Wang Zhongde , Wu Ailian 
Published: November 2022

AbstractElectrocatalytic oxidation technology has been proved as an efficient method for degradation in organic wastewater. The service lifetime and degradation efficiency of the electrode, one crucial struggle, limits the broad application of electrocatalytic oxidation technology. Herein, a Ru/Ir doped TiO2 electrode with a long service lifetime was developed. Accelerated life experiment showed that the service life of an electrode was 33 h when the concentration of sulfuric acid was 1 M and the current density was 2000 mA·cm−2. The influence on the phenol degradation was evaluated by researching the operating parameters. In particular, the possible mechanism of phenol removal at different pH is elucidated. It is found that acidic environment is favorable for chemical oxygen demand (COD) and phenol removal at a current density of 20 mA·cm−2, pH 3 at 800 ppm NaCl, which can make the removal rates of phenol and COD with Ru/Ir doped TiO2 anode up to 97.21% and 100%. In addition, it was demonstrated that the hydroxyl radicals play a foremost role in the degradation of phenol. Given the well stability and high service life, the Ru/Ir doped TiO2 electrode holds promise for further industrial application in wastewater treatment.
Capture‐bonding Super Assembly of Nanoscale Dispersed Bimetal on Uniform CeO2 Nanorod for the Toluene Oxidation
Authors: Zeng Zheng , Guan Ma Juan , Chen Hongyu , Xu Xiang , Zou Ma Jianwu , Zhang Ma Chongjie , Du Yankun , Li Liqing 
Published: November 2022

AbstractElimination of VOCs by catalytic oxidation is an important technology. Here, a general synergistic capture‐bonding superassembly strategy was proposed to obtain the nanoscale dispersed 5.8% PtFe3−CeO2 catalyst, which showed a high toluene oxidation activity (T100=226 °C), excellent catalytic stability (125 h, >99.5%) and a good water resistance ability (70 h, >99.5%). Through the detailed XPS analysis, oxygen cycle experiment, hydrogen reduction experiment, and in‐situ DRIFT experiment, we could deduce that PtFe3−CeO2 had two reaction pathways. The surface adsorbed oxygen resulting from PtFe3 nanoparticles played a dominant role, due to the fast cycling between the surface adsorbed oxygen and oxygen vacancy. In contrast, the lattice oxygen resulting from CeO2 nanorods played an important role due to the relationship between the toluene oxidation activity and the metal‐oxygen bonding energy. Furthermore, DFT simulation verified Pt sites were the dominant reaction active sites during this reaction.
CuCl2‐Catalyzed α‐Chloroketonation of Aromatic Alkenes via Visible‐Light‐Induced LMCT
Authors: He Xing‐Xian , Chang Huan‐Huan , Zhao Ying‐Xue , Li Xiang‐Jie , Liu Sheng‐An , Zang Zhong‐Lin , Zhou Cheng‐He , Cai Gui‐Xin 
Published: November 2022

AbstractHere we report a copper‐catalyzed protocol for the synthesis of α‐chloroketones from aromatic alkenes including electron‐deficient olefins under visible‐light irradiation. Preliminary mechanistic studies show that the peroxo Cu(II) species is the key intermediate and hydroperoxyl (HOO⋅) and chlorine (Cl⋅) radicals can be generated by ligand‐to‐metal charge transfer (LMCT).
Cascade cycloadditions of N‐aromatic zwitterions and allylic sulfonium ylides: Dual roles of the allylic sulfonium ylide in the cascade reaction
Authors: Jen Hyundug , Yoo Eun Jeong 
Published: November 2022

AbstractDearomative cycloadditions of N‐aromatic zwitterions have been performed to synthesize diverse N‐containing cyclic compounds. However, few practical syntheses of polycyclic molecules are reported, and thus, a novel methodology is necessary. We describe cascade reactions of N‐aromatic zwitterions and allylic sulfonium ylides to furnish fused N‐heterocyclic compounds. Unprecedentedly, molecules of the allylic sulfonium ylide react with the corresponding zwitterion as C1 and C3 synthons in the same reaction.
Use of practice tests with immediate feedback in an undergraduate molecular biology course
Authors: Plasencia Javier 
Published: November 2022

AbstractMultiple studies have shown that testing contributes to learning at all educational levels. In this observational classroom study, we report the use of a learning tool developed for a Genetics and Molecular Biology course at the college level. An interactive set of practice exams that included 136 multiple choice questions (MCQ) or matching queries was developed in the open‐source Moodle platform. All MCQ questions contained four answer choices and configured for immediate feedback upon answering. Feedback consisted of providing the right answer and a short explanation of the learning objective examined. The interactive material was tested and refined for several semesters. Usefulness of this tool was assessed in two distinct settings: (1) during a face‐to‐face semester (Fall 2019) by comparing the grades in a final departmental exam between students who used the tool and those who did not, and (2) during an online semester (Fall 2020) by analyzing the grades in the first and last attempts on study sessions and students' performance in monthly exams. We found that when solving practice tests, students obtained a significantly higher scores in the last attempt compared with their first attempt, and that students who used the material performed better than those who did not. In all cases, answering the practice exams was optional, but students made full use of them preferentially during the online semester. This classroom research exemplifies the documented effectiveness of practice tests enhanced with feedback in biological sciences education through an open‐source learning platform.
Management of a patient with a severely infraoccluded primary molar and hypodontia
Authors: Ng Alaina , Ong Desmond , Goh Phillip 
Published: November 2022

AbstractInfraocclusion of a primary molar is a relatively common occurrence which seldom leads to serious complications, particularly when the succedaneous permanent tooth is present. Despite the relative infrequency of unfavorable outcomes, an infraoccluded primary molar may be associated with other dental anomalies, including hypodontia. If diagnosis is delayed, infraocclusion of a primary molar can become severe, with associated negative effects on the adjacent teeth and alveolar bone. This emphasizes the need for routine and periodic orthodontic assessment of growing patients. Any deviation from the normal eruption sequence of teeth should be diagnosed and managed in a timely manner, to preserve dental arch integrity and reduce the potential for undesirable outcomes. This case report demonstrates how comprehensive assessment of the dentition, logical treatment planning and careful management of challenging orthodontic tooth movements can combine to provide a pleasing treatment outcome.
Cerebral venous sinus thrombosis following intracerebral hemorrhage after COVID‐19 AstraZeneca vaccination: A case report
Authors: Haj Mohamad Ebrahim Ketabforoush Arsh , Molaverdi Ghazale , Nirouei Matineh , Abbasi Khoshsirat Nahid 
Published: November 2022

AbstractThe patient was a 55‐year‐old female patient who presented with sudden onset of left hemiplegia, facial hemiparesis, and hypoesthesia. She has received her first dose of the AstraZeneca COVID‐19 vaccine. This case indicates that vaccination may raise the hypercoagulable state even in a condition of post‐ICH and anticoagulant prophylaxis.
There's not always one enemy: Co‐infection of campylobacter jejuni and non‐typhoidal salmonella in a patient with systemic lupus erythematosus
Authors: Asatori Daisuke , Shimada Kota 
Published: November 2022

AbstractA 22‐year‐old, female patient with systemic lupus erythematosus experienced bacterial enteritis. A stool Gram stain revealed Campylobacter. Non‐typhoidal Salmonella was detected in a stool culture, and Campylobacter jejuni was detected in a blood culture. Based on these findings, co‐infection of Campylobacter jejuni and non‐typhoidal Salmonella was diagnosed.
Developmental regression and movement disorder as a phenotypic variant of POLR3A Mutation—Case report
Authors: Nikkhah Ali , Rezakhani Sepideh 
Published: November 2022

AbstractPOLR3A is a main subunit encoding RNA polymerase III, which is involved in transcription of many RNA structures. Here, we report a new presentation of c.1771‐6C > G intronic variant presenting as developmental regression, seizure, and dystonia in a 6‐year‐old boy associated with striatum involvement in the brain MRI.
Giant pulmonary bulla causing respiratory compromise in a very low‐birthweight infant
Authors: Shinohara Tamao , Hasebe Yohei , Watanabe Daisuke , Sakurayama Tomohide , Maebayashi Yuki , Numano Fuminori , Saito Tomohiro , Koizumi Keiichi , Nemoto Atsushi , Saito Akitoshi , Oyama Toshio , Oyachi Noboru , Hoshiai Minako , Naitoh Atsushi 
Published: November 2022

AbstractAcquired cystic lung disease in premature infants is a serious respiratory complication, and pulmonary interstitial emphysema (PIE) has been widely reported. We report a rare case of giant pulmonary bulla in an infant treated with bullectomy where chest computed tomography was useful in directing treatment.
Pulmonary vein stenosis presenting as massive hemoptysis, treated with pulmonary veins angioplasty
Authors: Akiki Laura , Siblani Dima , Abi Saleh Wajdy , Chamoun Clara , Abouzahr Labib , Shatila Wassim 
Published: November 2022

AbstractTwo patients with history of cardiac ablation presented with massive hemoptysis secondary to pulmonary vein stenosis. They underwent successful pulmonary vein angioplasty and stenting. Although the second patient ended up having a lobectomy, the successful opening of the Left Superior Pulmonary Vein helped sparing the superior lobe and lingula.
Pharmacokinetic equivalence of CT‐P39 and reference omalizumab in healthy individuals: A randomised, double‐blind, parallel‐group, Phase 1 trial
Authors: Maurer Marcus , Saini Sarbjit S. , McLendon Kristi , Wabnitz Paul , Kim Sunghyun , Ahn Keumyoung , Kim Suyoung , Lee Sewon , Grattan Clive 
Published: November 2022

AbstractBackgroundCT‐P39 is being developed as a biosimilar of reference omalizumab. This study aimed to assess the pharmacokinetic equivalence of CT‐P39 to European Union‐approved and United States‐licensed reference omalizumab (EU‐ and US‐omalizumab, respectively).MethodsThis two‐part, randomised, parallel‐group, double‐blind Phase 1 trial (NCT04018313) was conducted in healthy individuals with a total immunoglobulin E (IgE) level ≤100 international units (IU)/ml at screening. In part 2, described herein, participants were randomised (1:1:1) to receive a single 150 mg subcutaneous dose of CT‐P39, EU‐omalizumab, or US‐omalizumab. The primary endpoint was pharmacokinetic equivalence in terms of area under the concentration–time curve (AUC) from time zero to the last quantifiable concentration (AUC0–last), AUC from time zero to infinity (AUC0‐inf), and maximum serum concentration (Cmax). Equivalence was concluded if 90% confidence intervals (CIs) of the geometric least‐squares means ratios were contained within the predefined 80%–125% equivalence margin. Additional pharmacokinetic parameters, pharmacodynamics, safety, and immunogenicity were also evaluated.ResultsOverall, 146 participants were randomised (CT‐P39, N = 47; EU‐omalizumab, N = 49; US‐omalizumab, N = 50). For all primary pharmacokinetic parameters, 90% CIs for pairwise treatment comparisons were within the 80%–125% equivalence margin, demonstrating pharmacokinetic equivalence. Decreases in free IgE and increases in total IgE serum concentrations were comparable across groups. CT‐P39 was well tolerated. Safety endpoints were comparable across groups: there were no treatment‐related serious adverse events, deaths, or discontinuations due to treatment‐emergent adverse events.ConclusionsCT‐P39 was well tolerated and demonstrated pharmacokinetic equivalence with EU‐omalizumab and US‐omalizumab following administration of a single dose in healthy individuals.
ESLO: Enhanced sea lion optimization based bi‐directional CNN‐RNN for accurate detection of diabetic retinopathy
Authors: Desika Vinayaki V. , Kalaiselvi R. 
Published: November 2022

SummaryDiabetic retinopathy is considered to be one of the major causes of eye disorder which commonly occurs in working age group of people worldwide. Deficiency of proper screening and early diagnosing leads the diabetic patients completely affected by vision loss. Therefore, an effective detection of diabetic retinopathy before visual symptoms reduces the impact of visual impairment. In recent times, numerous research methods are adopted by researchers in this domain to automatically detect the existence of eye diseases; however, they provide only limited performances like less accuracy with high training error. Therefore, in this article, an attention based bi‐directional convolutional neural network‐recurrent neural network model along with enhanced sea lion optimization (ABCDM‐ESLO) technique is proposed for accurate detection and classification of healthy and unhealthy diabetic retinopathy cases based on the severity levels. In this, seven different datasets are used, analyzed, and classified into five categories (i.e., normal, mild, moderate, severe, and proliferative). Moreover, the performance metrics such as accuracy, sensitivity, specificity, and f‐score are evaluated with respect to severity levels thereby determining the efficiency of the proposed method. The performance of the proposed technique is examined by comparing it with other existing methods. The proposed method achieves 99.2% of detection accuracy, 94% of sensitivity, 96% of specificity, and 92.75% of f‐score. This reveals that the proposed ABCDM‐ESLO technique performs well and classifies than other existing methods in terms of different performance metrics.
γ‐Valerolactone as Sustainable and Low‐Toxic Solvent for Electrical Double Layer Capacitors
Authors: Teoh Khai Shin , Melchiorre Massimo , Kreth Fabian Alexander , Bothe Annika , Köps Lukas , Ruffo Francesco , Balducci Andrea 
Published: November 2022

AbstractIn this work, γ‐valerolactone (GVL), a green solvent based on largely available biomass (carbohydrates), highly biodegradable, and with low eco‐toxicological profile, was used as electrolyte component in energy storage devices. This solvent allowed the realization of electrolytes with good transport properties and high thermal stability, which could be successfully applied in electrical double layer capacitors (EDLCs). GVL‐based EDLCs could operate at 2.7–2.9 V and displayed good performance in term of capacitance, cycling stability, as well as specific energy and power. The results of this study indicate that the use of solvent obtained from largely available natural sources is a feasible strategy for the realization of sustainable and safe electrolytes for EDLCs.
Multistep Transformation from Amorphous and Nonporous Fullerenols to Highly Crystalline Microporous Materials
Authors: Hardian Rifan , Szekely Gyorgy 
Published: November 2022

AbstractThe structural and morphological properties of fullerenols upon exposure to heat treatment have yet to be understood. Herein, the temperature‐driven structural and morphological evolutions of fullerenols C60(OH) and C70(OH) were investigated. In situ spectroscopic techniques, such as variable‐temperature X‐ray diffraction and coupled thermogravimetric Fourier‐transform infrared analysis, were used to elucidate the structural transformation mechanism of fullerenols. Both fullerenols underwent four‐step structural transformation upon heating and cooling, including amorphous‐to‐crystalline transition, thermal expansion, structural compression, and new crystal formation. Compared to the initially nonporous amorphous fullerenol, the crystalline product exhibited microporosity with a surface area of 114 m2 g−1 and demonstrated CO2 sorption capability. These findings show the potential of fullerene derivatives as adsorbents.
Half‐bridge Z‐source inverter based on T‐source configuration with continuous input current and a high boost factor
Authors: Laali Sara , Babaei Ebrahim , Aalami Mohammadamin 
Published: November 2022

SummaryThis paper proposes a new half‐bridge‐based impedance source inverter with coupled T‐shaped inductors. The proposed inverter has a continuous input current and a high boost factor. The proposed topology is thoroughly investigated, along with its operating modes and control system, and the boost factor equation is derived. Additionally, the operating modes' results are incorporated into the design of used components, such as capacitors and inductors. To determine the suggested topology's advantages and disadvantages, a comparison with similar topologies is made based on the number of power electronic devices employed, the boost factor, and the voltage stresses experienced by the components. On the base of these comparisons, it is concluded that the proposed half‐bridge‐based Z‐source inverter has a high boost factor, fewer power electronic components, and reduced voltage stresses. Following that, a power loss study is performed to ascertain the system's power losses and overall efficiency. The prototype's experimental results are considered to evaluate the proposed topology's correct performance.
Identification of BGN and THBS2 as metastasis‐specific biomarkers and poor survival key regulators in human colon cancer by integrated analysis
Authors: He Zhicheng , Lin Jian , Chen Cheng , Chen Yuanzhi , Yang Shuting , Cai Xianghai , He YingYing , Liu Shubai 
Published: November 2022

AbstractBackgroundColon cancer is the second leading cause of death worldwide. Exploring key regulators in colon cancer metastatic progression could lead to better outcomes for patients.MethodsInitially, the transcriptional profiles of 681 colonrectal cancer (CRC) cases were used to discover signature genes that were significantly correlated with colon cancer metastasis. These signature genes were then validated using another independent 210 CRC cases’ transcriptomics and proteomics profiles, and Kaplan–Meier regression analyses were used to screen the key regulators with patients’ survival. Immunohistochemical staining was used to confirm the biomarkers, and transit knockdown was used to explore their implications on colon cancer cells migration and invasion abilities. The impact on the key signalling molecules in epithelial‐mesenchymal transition (EMT) process that drive tumour metastasis was tested using Western blot. The response to clinical standard therapeutic drugs was compared to clinical prognosis of key regulators using an ROC plotter.ResultsFive genes (BGN, THBS2, SPARC, CDH11 and SPP1) were initially identified as potential biomarkers and therapeutic targets of colon cancer metastasis. The most significant signatures associated with colon cancer metastasis were determined to be BGN and THBS2. Furthermore, highly expression of BGN and THBS2 in tumours was linked to a worse survival rate. BGN and THBS2 knockdown significantly reduced colon cancer cells migration and invasion, as well as down‐regulating three EMT‐related proteins (Snail, Vimentin and N‐cadherin), and increasing the proliferation inhibitory effect of 5‐fluorouracil, irinotecan and oxaliplatin treatment.ConclusionsCRC metastatic progression, EMT phenotypic transition and poor survival time have been linked to BGN and THBS2. They could be utilized as potential diagnostic and therapeutic targets for colon cancer metastatic patients with a better prognosis.