bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered bladder‐related brain network in multiple sclerosis women with voiding dysfunction
Authors: Shi Zhaoyue , Karmonik Christof , Soltes Amelia , Tran Khue , Lincoln John A. , Boone Timothy , Khavari Rose 
Published: July 2022

AbstractObjectivesA number of neurourology imaging studies have mainly focused on investigating the brain activations during micturition in healthy and neuropathic patients. It is, however, also necessary to study brain functional connectivity (FC) within bladder‐related regions to understand the brain organization during the execution of bladder function. This study aims to identify the altered brain network associated with bladder function in multiple sclerosis (MS) women with voiding dysfunction through comparisons with healthy subjects via concurrent urodynamic study (UDS)/functional magnetic resonance imaging (fMRI).Materials and MethodsTen healthy adult women and nine adult ambulatory women with clinically stable MS for ≥6 months and symptomatic voiding phase neurogenic lower urinary tract dysfunction (NLUTD) underwent UDS/fMRI evaluation with a task of bladder filling/emptying that was repeated three to five times. We quantitatively compared their FC within 17 bladder‐related brain regions during two UDS phases: “strong desire to void” and “(attempt at) voiding initiation.”ResultsAt “strong desire to void,” the healthy group showed significantly stronger FC in regions involved in bladder filling and suppression of voiding compared to the patient group. These regions included the bilateral anterior cingulate cortex, right supplementary motor area, and right middle frontal gyrus. During “(attempt at) voiding initiation,” healthy subjects exhibited stronger FC in the right inferior frontal gyrus compared to MS patients.ConclusionOur study offers a new way to identify alterations in the neural mechanisms underlying NLUTD and provides potential targets for clinical interventions (such as cortical neuromodulation) aimed at restoring bladder functions in MS patients.
Uncivil society and social policies in Brazil: The backlash in the gender, sexual, and reproductive rights and ethnic and racial relations fields
Authors: Segatto Catarina Ianni , Alves Mario Aquino , Pineda Andrea 
Published: July 2022

AbstractThis paper analyzes how dynamics between Brazil's right‐wing populist government and civil and uncivil organizations affected the role of civil organizations, especially rights‐based ones, and Brazil's democratization process. These dynamics contributed to stripping policies of their progressive nature and rejecting the values of diversity, freedom, and equality. Our analysis relies on the inhabited institutions approach to comprehend the role of action, interaction, and meaning in institutionalized spaces. We analyzed two policy fields—gender, sexual, and reproductive rights, and ethnic and racial relations—through documents and in‐depth interviews. Our analysis shows that Bolsonaro's government mobilized mechanisms related to institutional changes, the replacement of actors, and their interactions to inhibit civil society organizations' influence in policy formulation and provision and strengthen the participation of uncivil groups, thereby legitimating conservative ideas and discourses, and closing civic space for NGOs with rights‐based agendas.
Effect of stacking sequence and silicon carbide nanoparticles on properties of carbon/glass/Kevlar fiber reinforced hybrid polymer composites
Authors: Karthik Krishnasamy , Prakash Jayavelu Udaya , Binoj Joseph Selvi , Mansingh Bright Brailson 
Published: July 2022

AbstractSynthetic fibers as reinforcement in composites are inevitable in today's composite industry due to its exceptional mechanical properties. The objective of this paper is to investigate the effect of stacking sequence of carbon, glass and Kevlar bidirectional (0°/90°) woven mat synthetic fibers reinforced in epoxy matrix composite with silicon carbide (SiC) nanoparticles as filler material on mechanical and visco‐elastic behavior of developed novel hybrid polymer matrix composites (HPMCs). Vacuum bag infusion method is adopted to manufacture the composite specimens by stacking carbon, glass and Kevlar fibers alternatively with six layers and six different stacking sequences and tested as per ASTM standards. Tensile, flexural, impact and hardness test is conducted to identify the composite specimen with maximum mechanical characteristics. The maximum tensile and flexural strength of 398.178 and 671.25 MPa respectively is seen for the composite with strong fibers such as carbon and glass stacked away from the neutral axis. Also, the scanning electron microscope (SEM) images of tensile and flexural failure specimen revealed the failure mechanisms of developed composite specimens. Moreover, the dynamic mechanical analysis (DMA) revealed the visco‐elastic behavior of developed composites with glass transition temperature (Tg) at 115°C. This study emphasizes the influence of stacking sequence on thermo‐mechanical properties of the developed HPMC specimens and explores its potential for diverse applications.
Parental migration status moderates the link between parent–child relationship and children's well‐being through psychological distress
Authors: Mordeno Imelu G. , Gallemit I Marie Joy S. , Bangcola Bea Fatima B. , Busaco Jinky Joy Jessica L. , Tuto Reignajean T. , Hall Brian J. 
Published: July 2022

AbstractThe effects of parental migration on the well‐being of left‐behind children (LBC) are varied. Several studies demonstrated that parental migration reduces children's psychological health but other research showed contradictory results. This study sought to clarify this issue by examining the mediating role of psychological distress and the moderating role of parental migration status in the association between the parent–child relationship and children's psychological distress. A total of 743 LBC and 688 non‐LBC self‐reported their parent–child relationship, psychological distress, and well‐being. Findings showed that psychological distress mediated the association between parent–child relationship and children's well‐being. This denotes that greater parent–child relationship results into lowered levels of psychological distress, and in turn, increases children's emotional, psychological, and social well‐being. Moreover, the link between parent–child relationship and psychological distress was found to be contingent to parental migration status. Specifically, the negative association between parent–child relationship and psychological distress was especially strong among LBC in contrast to non‐ LBC. This implies that children with higher quality relationships with their parents tend to exhibit decreased severity of psychological distress symptoms, especially in children whose parents are working overseas. These results underscore the dynamic role of parent–child relationship in the well‐being of LBC, and suggest ways to develop intervention programs that include cultivating skills in managing psychological distress and improving the emotional, psychological, and social well‐being of LBC.
Predicting residue‐specific qualities of individual protein models using residual neural networks and graph neural networks
Authors: Zhao Chenguang , Liu Tong , Wang Zheng 
Published: July 2022

AbstractThe estimation of protein model accuracy (EMA) or model quality assessment (QA) is important for protein structure prediction. An accurate EMA algorithm can guide the refinement of models or pick the best model or best parts of models from a pool of predicted tertiary structures. We developed two novel methods: MASS2 and LAW, for predicting residue‐specific or local qualities of individual models, which incorporate residual neural networks and graph neural networks, respectively. These two methods use similar features extracted from protein models but different architectures of neural networks to predict the local accuracies of single models. MASS2 and LAW participated in the QA category of CASP14, and according to our evaluations based on CASP14 official criteria, MASS2 and LAW are the best and second‐best methods based on the Z‐scores of ASE/100, AUC, and ULR‐1.F1. We also evaluated MASS2, LAW, and the residue‐specific predicted deviations (between model and native structure) generated by AlphaFold2 on CASP14 AlphaFold2 tertiary structure (TS) models. LAW achieved comparable or better performances compared to the predicted deviations generated by AlphaFold2 on AlphaFold2 TS models, even though LAW was not trained on any AlphaFold2 TS models. Specifically, LAW performed better on AUC and ULR scores, and AlphaFold2 performed better on ASE scores. This means that AlphaFold2 is better at predicting deviations, but LAW is better at classifying accurate and inaccurate residues and detecting unreliable local regions. MASS2 and LAW can be freely accessed from http://dna.cs.miami.edu/MASS2-CASP14/ and http://dna.cs.miami.edu/LAW-CASP14/, respectively.
Data‐driven maintenance planning and scheduling based on predicted railway track condition
Authors: Sedghi Mahdieh , Bergquist Bjarne , Vanhatalo Erik , Migdalas Athanasios 
Published: July 2022

AbstractTimely planning and scheduling of railway infrastructure maintenance interventions are crucial for increased safety, improved availability, and reduced cost. We propose a data‐driven decision‐support framework integrating track condition predictions with tactical maintenance planning and operational scheduling. The framework acknowledges prediction uncertainties by using a Wiener process‐based prediction model at the tactical level. We also develop planning and scheduling algorithms at the operational level. One algorithm focuses on cost‐optimisation, and one algorithm considers the multi‐component characteristics of the railway track by grouping track segments near each other for one maintenance activity. The proposed framework's performance is evaluated using track geometry measurement data from a 34 km railway section in northern Sweden, focusing on the tamping maintenance action. We analyse maintenance costs and demonstrate potential efficiency increases by applying the decision‐support framework.
Regularity Theory for Non-autonomous Partial Differential Equations Without Uhlenbeck Structure
Authors: Hästö Peter , Ok Jihoon 
Published: July 2022

AbstractWe establish maximal local regularity results of weak solutions or local minimizers of $$\begin{aligned} \mathrm {div}A(x, Du)=0 \quad \text {and}\quad \min _u \int _\Omega F(x,Du)\,\mathrm{d}x, \end{aligned}$$

div
A

(
x
,
D
u
)

=
0

and

min
u

∫
Ω

F

(
x
,
D
u
)

d
x
,

providing new ellipticity and continuity assumptions on A or F with general (p, q)-growth. Optimal regularity theory for the above non-autonomous problems is a long-standing issue; the classical approach by Giaquinta and Giusti involves assuming that the nonlinearity F satisfies a structure condition. This means that the growth and ellipticity conditions depend on a given special function, such as $$t^p$$

t
p

, $$\varphi (t)$$

φ
(
t
)

, $$t^{p(x)}$$

t

p
(
x
)

, $$t^p+a(x)t^q$$

t
p

+
a

(
x
)

t
q

, and not only F but also the given function is assumed to satisfy suitable continuity conditions. Hence these regularity conditions depend on given special functions. In this paper we study the problem without recourse to, special function structure and without assuming Uhlenbeck structure. We introduce a new ellipticity condition using A or F only, which entails that the function is quasi-isotropic, i.e. it may depend on the direction, but only up to a multiplicative constant. Moreover, we formulate the continuity condition on A or F without specific structure and without direct restriction on the ratio $$\frac{q}{p}$$

q
p

of the parameters from the (p, q)-growth condition. We establish local $$C^{1,\alpha }$$

C

1
,
α

-regularity for some $$\alpha \in (0,1)$$

α
∈
(
0
,
1
)

and $$C^{\alpha }$$

C
α

-regularity for any $$\alpha \in (0,1)$$

α
∈
(
0
,
1
)

of weak solutions and local minimizers. Previously known, essentially optimal, regularity results are included as special cases.
RELAY, ramucirumab plus erlotinib versus placebo plus erlotinib in untreated EGFR-mutated metastatic non-small cell lung cancer: exposure–response relationship
Authors: Nakagawa Kazuhiko , Garon Edward B. , Gao Ling , Callies Sophie , Zimmermann Annamaria , Walgren Richard , Visseren-Grul Carla , Reck Martin 
Published: July 2022

Abstract
Purpose
In RELAY, ramucirumab plus erlotinib (RAM + ERL) improved progression-free survival (PFS) in patients with untreated, metastatic, EGFR-mutated, non-small cell lung cancer (NSCLC). Here, we present the exposure–response relationship of RAM from RELAY.

Methods
Patients received ERL (150 mg/day) with either RAM (10 mg/kg) or placebo (PBO + ERL) every 2 weeks (Q2W). A population pharmacokinetic model predicted RAM minimum concentration after first dose (Cmin,1), and at steady state (Cmin,ss), which were used to evaluate correlation between RAM exposure and efficacy and safety. The Kaplan–Meier method and Cox regression analyses were utilized to evaluate exposure–efficacy by Cmin,1 quartile. Exposure–safety was evaluated by assessing incidence rates for safety parameters by Cmin,ss quartile, with ordered categorical analysis used for ALT/AST only.

Results
Analyses included 216 patients treated with RAM + ERL and 225 patients treated with PBO + ERL. Adjusting for significant baseline covariates, no exposure–efficacy relationship was identified in RELAY: PFS hazard ratio (mean, 95% confidence intervals) for the Cmin,1 quartiles were 0.67 (0.45–0.99), 0.77 (0.53–1.12), 0.57 (0.38–0.84), and 0.50 (0.33–0.76). No apparent exposure–safety relationship was observed for selected safety endpoints, including Grade ≥ 3 hypertension, diarrhea, and dermatitis acneiform, and any grade hypertension, any grade and Grade ≥ 3 proteinuria, and any grade ALT/AST increased within liver failure/liver injury.

Conclusions
No association was observed between RAM exposure and response, suggesting that the RELAY regimen of RAM 10 mg/kg Q2W with ERL is an optimized, efficacious, and safe first-line treatment for patients with untreated, metastatic, EGFR-mutated NSCLC.
Trial registration: ClinicalTrials.gov, NCT02411448.
Persistent organic pollutants and mercury in a colony of Antarctic seabirds: higher concentrations in 1998, 2001, and 2003 compared to 2014 to 2016
Authors: Kuepper Nadja D. , Böhm Leonard , Braun Christina , Bustamante Paco , Düring Rolf-Alexander , Libertelli Marcela M. , Quillfeldt Petra 
Published: July 2022

AbstractOver decades, persistent organic pollutants (POPs) and trace metals like mercury (Hg) have reached the remotest areas of the world such as Antarctica by atmospheric transport. Once deposited in polar areas, low temperatures, and limited solar radiation lead to long environmental residence times, allowing the toxic substances to accumulate in biota. We investigated the load of polychlorinated biphenyls (PCBs) and dichlorodiphenyltrichloroethane (DDTs) and metabolites (DDEs, DDDs) in embryos from failed eggs of the smallest seabird breeding in Antarctica, the Wilson's storm-petrel (Oceanites oceanicus) at King George Island (Isla 25 de Mayo). We compared samples of different developmental stages collected in 2001, 2003, and 2014 to 2016 to investigate changes in pollutant concentrations over time. We detected eight PCBs including the dioxin-like (dl) congeners PCB 105 and 118 (ΣPCBs: 59-3403 ng g−1ww) as well as 4,4’-DDE, and 4,4’-DDD (ΣDDX: 19-1035 ng g−1ww) in the embryos. Samples from the years 2001 and 2003 showed higher concentrations of PCBs than those from 2014 to 2016. Concentrations of DDX was similar in both time intervals. Furthermore, we determined Hg concentrations in egg membranes from 1998 to 2003, and 2014 to 2016. Similar to PCBs, Hg in egg membranes were higher in 1998 than in 2003, and higher in 2003 than in the years 2014 to 2016, suggesting a slow recovery of the pelagic Antarctic environment from the detected legacy pollutants. Embryos showed an increase in pollutant concentrations within the last third of their development. This finding indicates that contaminant concentrations may differ among developmental stages, and it should be taken into account in analyses on toxic impact during embryogenesis.
Winter wet–dry weather patterns driving atmospheric rivers and Santa Ana winds provide evidence for increasing wildfire hazard in California
Authors: Guirguis Kristen , Gershunov Alexander , Hatchett Benjamin , Shulgina Tamara , DeFlorio Michael J. , Subramanian Aneesh C. , Guzman-Morales Janin , Aguilera Rosana , Clemesha Rachel , Corringham Thomas W. , Delle Monache Luca , Reynolds David , Tardy Alex , Small Ivory , Ralph F. Martin 
Published: July 2022

AbstractFloods caused by atmospheric rivers and wildfires fanned by Santa Ana winds are common occurrences in California with devastating societal impacts. In this work, we show that winter weather variability in California, including the occurrence of extreme and impactful events, is linked to four atmospheric circulation regimes over the North Pacific Ocean previously named and identified as the “NP4 modes”. These modes come in and out of phase with each other during the season, resulting in distinct weather patterns that recur throughout the historical record. Some phase combinations favor atmospheric river landfalls and extreme daily or multi-day precipitation, while other phase combinations favor anomalously hot weather and drying Santa Ana wind conditions over Southern California. This historical perspective of atmospheric circulation and impacts over 70 years reveals that weather patterns are changing in a way that enhances wildfire hazard in California, while the frequency of weather patterns linked to historical floods is not diminishing. These changes highlight the rising hazards of cascading weather extremes in California’s present and future.
Monoamine oxidase A and organic cation transporter 3 coordinate intracellular β1AR signaling to calibrate cardiac contractile function
Authors: Wang Ying , Zhao Meimi , Xu Bing , Bahriz Sherif M. F. , Zhu Chaoqun , Jovanovic Aleksandra , Ni Haibo , Jacobi Ariel , Kaludercic Nina , Di Lisa Fabio , Hell Johannes W. , Shih Jean C. , Paolocci Nazareno , Xiang Yang K. 
Published: July 2022

AbstractWe have recently identified a pool of intracellular β1 adrenergic receptors (β1ARs) at the sarcoplasmic reticulum (SR) crucial for cardiac function. Here, we aim to characterize the integrative control of intracellular catecholamine for subcellular β1AR signaling and cardiac function. Using anchored Förster resonance energy transfer (FRET) biosensors and transgenic mice, we determined the regulation of compartmentalized β1AR-PKA signaling at the SR and plasma membrane (PM) microdomains by organic cation transporter 3 (OCT3) and monoamine oxidase A (MAO-A), two critical modulators of catecholamine uptake and homeostasis. Additionally, we examined local PKA substrate phosphorylation and excitation–contraction coupling in cardiomyocyte. Cardiac-specific deletion of MAO-A (MAO-A-CKO) elevates catecholamines and cAMP levels in the myocardium, baseline cardiac function, and adrenergic responses. Both MAO-A deletion and inhibitor (MAOi) selectively enhance the local β1AR-PKA activity at the SR but not PM, and augment phosphorylation of phospholamban, Ca2+ cycling, and myocyte contractile response. Overexpression of MAO-A suppresses the SR-β1AR-PKA activity and PKA phosphorylation. However, deletion or inhibition of OCT3 by corticosterone prevents the effects induced by MAOi and MAO-A deletion in cardiomyocytes. Deletion or inhibition of OCT3 also negates the effects of MAOi and MAO-A deficiency in cardiac function and adrenergic responses in vivo. Our data show that MAO-A and OCT3 act in concert to fine-tune the intracellular SR-β1AR-PKA signaling and cardiac fight-or-flight response. We reveal a drug contraindication between anti-inflammatory corticosterone and anti-depressant MAOi in modulating adrenergic regulation in the heart, providing novel perspectives of these drugs with cardiac implications.
X-linked myotubular myopathy is associated with epigenetic alterations and is ameliorated by HDAC inhibition
Authors: Volpatti Jonathan R. , Ghahramani-Seno Mehdi M. , Mansat Mélanie , Sabha Nesrin , Sarikaya Ege , Goodman Sarah J. , Chater-Diehl Eric , Celik Alper , Pannia Emanuela , Froment Carine , Combes-Soia Lucie , Maani Nika , Yuki Kyoko E. , Chicanne Gaëtan , Uusküla-Reimand Liis , Monis Simon , Alvi Sana Akhtar , Genetti Casie A. , Payrastre Bernard , Beggs Alan H. , Bonnemann Carsten G. , Muntoni Francesco , Wilson Michael D. , Weksberg Rosanna , Viaud Julien , Dowling James J. 
Published: July 2022

AbstractX-linked myotubular myopathy (XLMTM) is a fatal neuromuscular disorder caused by loss of function mutations in MTM1. At present, there are no directed therapies for XLMTM, and incomplete understanding of disease pathomechanisms. To address these knowledge gaps, we performed a drug screen in mtm1 mutant zebrafish and identified four positive hits, including valproic acid, which functions as a potent suppressor of the mtm1 zebrafish phenotype via HDAC inhibition. We translated these findings to a mouse XLMTM model, and showed that valproic acid ameliorates the murine phenotype. These observations led us to interrogate the epigenome in Mtm1 knockout mice; we found increased DNA methylation, which is normalized with valproic acid, and likely mediated through aberrant 1-carbon metabolism. Finally, we made the unexpected observation that XLMTM patients share a distinct DNA methylation signature, suggesting that epigenetic alteration is a conserved disease feature amenable to therapeutic intervention.
Increased susceptibility to Chrysanthemum Yellows phytoplasma infection in Atcals7ko plants is accompanied by enhanced expression of carbohydrate transporters
Authors: Bernardini Chiara , Santi Simonetta , Mian Giovanni , Levy Amit , Buoso Sara , Suh Joon Hyuk , Wang Yu , Vincent Christopher , van Bel Aart J. E. , Musetti Rita 
Published: July 2022

Main conclusion
Loss of CALS7 appears to confer increased susceptibility to phytoplasma infection in Arabidopsis, altering expression of genes involved in sugar metabolism and membrane transport.

Abstract
Callose deposition around sieve pores, under control of callose synthase 7 (CALS7), has been interpreted as a mechanical response to limit pathogen spread in phytoplasma-infected plants. Wild-type and Atcals7ko mutants were, therefore, employed to unveil the mode of involvement of CALS7 in the plant’s response to phytoplasma infection. The fresh weights of healthy and CY-(Chrysanthemum Yellows) phytoplasma-infected Arabidopsis wild type and mutant plants indicated two superimposed effects of the absence of CALS7: a partial impairment of photo-assimilate transport and a stimulated phytoplasma proliferation as illustrated by a significantly increased phytoplasma titre in Atcal7ko mutants. Further studies solely dealt with the effects of CALS7 absence on phytoplasma growth. Phytoplasma infection affected sieve-element substructure to a larger extent in mutants than in wild-type plants, which was also true for the levels of some free carbohydrates. Moreover, infection induced a similar upregulation of gene expression of enzymes involved in sucrose cleavage (AtSUS5, AtSUS6) and transmembrane transport (AtSWEET11) in mutants and wild-type plants, but an increased gene expression of carbohydrate transmembrane transporters (AtSWEET12, AtSTP13, AtSUC3) in infected mutants only. It remains still unclear how the absence of AtCALS7 leads to gene upregulation and how an increased intercellular mobility of carbohydrates and possibly effectors contributes to a higher susceptibility. It is also unclear if modified sieve-pore structures in mutants allow a better spread of phytoplasmas giving rise to higher titre.