bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aplikasi Edmodo Sebagai Media Pembelajaran Berbasis E-learning
Authors: Sahlia  
Published: March 2022

Penelitian ini bertujuan untuk mengetahui penggunaan aplikasi edmodo sebagai media pembelajaran di era milenial. Kemajuan terhadap teknologi membawa dampak perubahan di semua bidang, salah satunya pada bidang pendidikan. Terlebih penggunaan media pembelajaran berbasis e-learning banyak digandrungi orang-orang terutama oleh para guru untuk menunjang aktivitas pembelajaran. Metode yang digunakan dalam penelitian ini adalah metode kualitatif. Berdasarkan hasil penelitian, maka dapat diambil kesimpulan bahwa edmodo digunakan sebagai penunjang pembelajaran jarak jauh berbentuk e-learning, di mana pembelajaran dapat dilakukan di manapun dan kapanpun. Edmodo akan menghubungkan guru, siswa, dan orangtua dalam satu wadah yang sama di mana ketiganya memiliki peran yang berbeda.

This research aims to determine the use of the Edmodo application as a learning medium in the millennial era. Advances in technology bring about changes in all fields, one of which is in the field of education. Moreover, the use of e-learning based learning media is loved by many people, especially by teachers to support learning activities. The method used in this research is qualitative method. Based on the results of the research, it can be concluded that Edmodo is used as a support for distance learning in the form of e-learning, where learning can be done anywhere and anytime. Edmodo will connect teachers, students, and parents in the same place where the three have different roles.
Analysis of Cold-Formed Steel Built-up Closed Sections Strengthened with GFRP
Authors: PV Premalatha , LK Rex 
Published: March 2022

Abstract
cold form steel sections are widely preferred due to the ease of fabrication and economical construction. This paper presents the results of experimental and numerical investigation of a regular cold-form steel (CFS) section to that of the section strengthened with Glass Fiber Reinforced Polymer (GFRP). Numerical analysis was performed using ANSYS and the results are compared with the experimental results and literature study. From the results, it is proposed that the concept of strategically applying GFRP material to steel members would improve the buckling resistance and thereby the load carrying capacity by 40%. Local bucking was arrested and the columns were able to take 50% more load before reaching the critical yield point. Hence it is recommended to strengthen the CFS columns where ever dimensional restrictions are not present.
The Effects of Nano-curcumin Supplementation on Adipokines Levels in Obese and Overweight Patients With Migraine: a Double Blind Clinical Trial Study
Authors: Sedighiyan Mohsen , Abdolahi Mina , Jafari Elham , Vahabi Zahra , Athar Sara Sohrabi , Hadavi Shima , Zamanabadi Mahnaz Narimani , Yekaninejad Mir-Saeed , Djalali Mahmoud 
Published: March 2022

Abstract
Objective: The present study aimed to investigate the effects of nano-curcumin supplementation on adipokines levels and clinical signs in obese and overweight patients with migraine.Results: Forty-four patients with episodic migraine participated in this clinical trial and were divided into two groups as nano-curcumin (80 mg/day) and control group over a two-month period. At the baseline and the end of the research, the serum levels of MCP-1, Resistin and Visfatine were measured using ELISA method. In addition, the headache attack frequencies, severity and duration of pain were recorded. The results of the present study showed that nano-curcumin can significantly reduce MCP-1 serum levels in nano-curcumin supplemented group (P=0.015, size effect= 13.4%). In the case of resistin and visfatine, a greater reduction was found in nano-curcumin group but it was not statistically significant (P>0.05). Nano-curcumin also significantly reduced the attack frequencies, severity and duration of headaches (P<0.05). These findings indicate that targeting curcumin can be a promising approach to migraine management. However, further comprehensive human trials are needed to confirm these finding.Trial Registration: This study was registered in Iranian Registry of Clinical Trials (IRCT) with ID number: IRCT20160626028637N2.
Metabolomics analysis reveals different mechanisms of Cadmium response and functions of reduced glutathione in Cadmium detoxification in the Chinese cabbage
Authors: gao jianwei , He Lilong , Yuan Chao , Li Xin , Li Cheng , Li Yongqing , Chen Donghua , Zhang Wei , Zheng Han 
Published: March 2022

Abstract
Chinese cabbage (Brassica rapa) is one of the vegetable crops with the largest acreage and yield in East Asia. With the aggravation of heavy metal pollution in soil, the excessive accumulation of heavy metal has become increasingly severe in Chinese cabbage, among which, cadmium is one of the most representative elements. It is critical to understand the regulatory mechanism of Cadmium (Cd) response and tolerance in Chinese cabbage at the metabolism level. Comparative of functional metabolomics and transcript analyses were conducted in Chinese cabbage treated with different Cd concentrations. The results revealed that the transcript responses were not consistent with the metabolic responses, and Cd treatment at different concentrations could induce more specific differentially expressed metabolites. Moreover, the reduced glutathione (GSH) metabolism pathway was induced under the higher Cd stresses. The following result indicated that the GSH played a role in the reduction of Cd accumulation in Chinese cabbage under the higher Cd stresses but led to Cd accumulation under the low Cd stress. This study offers critical information on handling Cd contamination in Chinese cabbages at the different Cd contamination conditions. Different concentration of Cd stresses resulted different responses in Chinese cabbage, and GSH plays different roles in dealing with Cd concentration stresses in Chinese cabbage.
Climate Change Impact on Water Balance of Lake Hawassa Catchment
Authors: Gizachew Beyene Akirso and Seble , Gizachew Seble 
Published: March 2022

Abstract
This study assessed the impact of climate change (cc) on the water balance of the Lake Hawassa catchment. The CMhyd (Climate model data for hydrologic modeling) model was used to correct biases of the Representative Concentration Pathways (RCP) scenarios for 2050’s (2041–2070) and 2080’s (2071–2100). The impact of cc on water balance components was analyzed by Soil and Water Assessment Tool (SWAT) model and its very good performance during the calibrate and validate periods, respectively are coefficient of determination (R²) 0.61 and 0.88 and Nash-Sutcliffe efficiency (NSE) 0.81 and 0.85. Projected precipitation (ppt) decreased by 11.4% and 8% in RCP4.5 and 20.67% and 15% in RCP8.5 respectively in 2050s and 2080s. The projected minimum and maximum temperature (Tmin&Tmax) is increased by 26.2% and 15.6% under RCP4.5 and increased by 45.8% and 29.5% under RCP8.5 respectively. The future water balance of Lake Hawassa catchment under RCP4.5 and RCP8.5 by the end of 2100; ppt decreased by 12% and 27%, surface runoff increased by 10% and decreased by 16%, lateral discharge decreased by 39% and 50%, water yield decreased by 27% and 46%, evapotranspiration (ET) increased by 23% and 21% and potential evapotranspiration (PET) increased by 77% and 75.3% respectively. The increment in temperature and the decrement in ppt resulted increment in PET largely because the water holding capacity of air is increased. Moreover, the climatic variations and human influence the water balance of the study has affected. Therefore, constantly monitored and updated sustainable water resources management is needed in the area.
An optimization approach for designing carbon capture utilization and storage supply chain infrastructure with a multi-criterion decision making problem
Authors: NGUYEN TUAN BUI HUU , Leonzio Grazia 
Published: March 2022

Abstract
This study develops a framework for designing a carbon capture, utilization, and storage (CCUS) supply chain network with economic and environmental concerns. The target is to establish the best CCUS configuration pathways while considering the real geographic locations of CO2 sources, utilization/storage sinks, and various CO2-based products. The proposed problem is a multi-objective mixed-integer linear programming (MILP) problem where two objectives (costs and environmental impacts) are balanced. A two-dimensional Pareto front is constructed by implementing the ε-constraint method. The proposed framework is employed to address actual case research based on Germany in order to illustrate the model's capability. The results suggest that valuable insights achieved from the model can be applied to other countries at different scales (a state, region, nation level) and help decision-makers elect more sustainable options in the design of CCUS infrastructure.
Preceptors’ Preparedness to Teach About Substance and Opioid Use Disorder: A Qualitative Study
Authors: Lowe Enya , Kogan Alexis Coulourides , Feldman Corinne , Ma Sae Byul (Sarah) , Lie Désirée 
Published: March 2022

Abstract
Study Aim: Little is known about preceptors’ comfort and readiness to teach clinical students about the care of patients with substance and opioid use disorder (SUD/OUD). This study explores preceptors’ views about caring for such patients, and their preparedness to teach about SUD/OUD management, to improve graduate competencies.Methods: Particiants were recruited by convenience and snowball sampling. Semi-structured interviews were conducted with physician, physician assistant and nurse practitioner preceptors who taught medical and physician assistant students. Interviews were conducted via Zoom® videoconferencing. Transcripts were generated and independently analyzed for themes by 4 experienced coders using constant comparison and a grounded theory approach.Results: Fifteen interviews were conducted to theme saturation. We identified 3 major themes and 10 subthemes supported by exemplar quotes. The major themes were: education about SUD/OUD in primary care (subthemes include role modeling positive behaviors, negative patient bias as a barrier and need for longitudinal curriculum), treatment of SUD/OUD in primary care (need for systemic support and care continuity), and medication-assisted therapy (MAT) training as a tool for teaching (preceptors’ own training, and need for clinical students to be trained). Conclusions: Data analysis enabled the construction of a conceptual framework reflecting a continuum of preceptor comfort and preparedness to teach about SUD/OUD, associated with various barriers and motivators. This framework can guide future strategies to address facilitators and obstacles, in order to advance and promote preceptor preparedness to teach students about the care and management of patients with SUD/OUD.
Perinatal Predictors of Wheezing in the First Year of Life a Prospective Study in the South of Brazil
Authors: Veras Tiago Neves , Lima Helbert Nascimento , Pinto Leonardo Araujo , Cagliari Patricia Zanotelli , Silva Jean Carl 
Published: March 2022

Abstract
Introduction: Prematurity has been associated with the occurrence of respiratory symptoms throughout childhood, such as bronchiolitis and pneumonia. The identification of factors related to respiratory morbidity in childhood has direct implications for management and prevention. Objective: Evaluate the perinatal factors associated with wheezing in the first year of life in a prospective cohort of premature babies at a referral maternity hospital in southern Brazil.Methods: This is a prospective cohort of premature babies, less than 37 weeks of gestational age (defined by the Capurro Method or by ultrasound), and non-premature babies. The sample was non-probabilistic and defined by the ability to schedule follow-up appointments at the pulmonology outpatient clinic. The incidence rate for the occurrence of wheezing in the first year was estimated among full-term, premature, and extremely premature babies and adjusted for 1000 babies / year. Results: The number of newborns considered in the final analysis was 138 children (64 premature babies and 74 term babies). Regarding the general characteristics of the mothers, there was a predominance of low education (65.9%), of white ethnicity (79.7%), with an average age of 26 years. During the first year of life, 91 children (65.9%) visited the emergency room and 43 (31.2%) had at least one episode of wheezing. The occurrence of wheezing was 42.6% in male children (p = 0.010) 3). There was a higher percentage of wheezing episodes (35.9%) in preterm infants, especially those younger than 33 weeks (45%); however, this result was not statistically significant (p 0.260). In the multivariate analysis, only the male gender remained associated with the occurrence of wheezing in the first year of life (HR 2.24; 95% CI 1.19-4.21; p 0.012). Conclusions: In this follow-up study, the occurrence of wheezing in preterm infants in the first year of life was high, with twin pregnancy as the main risk factors, the male gender and the use of mechanical ventilation
The Mechanism of Activation of MEK1 by B-Raf and KSR1
Authors: Maloney Ryan Colin , Zhang Mingzhen , Liu Yonglan , Jang Hyunbum , Nussinov Ruth 
Published: March 2022

Abstract
MEK1 interactions with B-Raf and KSR1 are key steps in Ras/Raf/MEK/ERK signaling. Despite this, vital mechanistic details of how these execute signal transduction are still enigmatic. Among these is why, despite B-Raf and KSR1 kinase domains similarity, the B-Raf/MEK1 and KSR1/MEK1 complexes have distinct contributions to MEK1 activation, and broadly, what is KSR1’s role. Our molecular dynamics simulations clarify these still unresolved ambiguities. Our results reveal that the proline-rich (P-rich) loop of MEK1 plays a decisive role in MEK1 activation loop (A-loop) phosphorylation. In the inactive B-Raf/MEK1 heterodimer, the collapsed A-loop of B-Raf interacts with the P-rich loop and A-loop of MEK1, minimizing MEK1 A-loop fluctuation and preventing it from phosphorylation. In the active B-Raf/MEK1 heterodimer, the P-rich loop moves in concert with the A-loop of B-Raf as it extends. This reduces the number of residues interacting with MEK1 A-loop, allowing increased A-loop fluctuation, and bringing Ser222 closer to ATP for phosphorylation. B-Raf αG-helix Arg662 promotes MEK1 activation by orienting Ser218 towards ATP. In KSR1/MEK1, the KSR1 αG-helix has Ala826 in place of B-Raf Arg662. This difference results in much fewer interactions between KSR1 αG-helix and MEK1 A-loop, thus a more flexible A-loop. We postulate that if KSR1 were to adopt an active configuration with an extended A-loop as seen in other protein kinases, then the MEK1 P-rich loop would extend in a similar manner as is seen in the active B-Raf/MEK1 heterodimer. This would result in highly flexible MEK1 A-loop, and KSR1 functioning as an active, B-Raf-like, kinase.
Maintaining Implementation Through Dynamic Adaptations (MIDAS): Protocol for a Cluster-Randomized Trial of Implementation Strategies to Optimize and Sustain use of Evidence-based Practices Veteran Health Administration (VHA) Patients
Authors: Damschroder Laura , Sussman Jeremy B. , Pfeiffer Paul N. , Kurlander Jacob E. , Freitag Michelle B. , Robinson Claire H. , Spoutz Patrick , Christopher Melissa , Battar Saraswathy , Dickerson Kimberly , Sedgwick Christopher , Wallace-Lacey Ashleigh G. , Barnes Geoffrey D , Linsky Amy M , Ulmer Christie S. , Lowery Julie C. 
Published: March 2022

Abstract
Background
The adoption and sustainment of evidence-based practices (EBPs) is a challenge within many healthcare systems, especially in settings that have already strived but failed to achieve longer-term goals. The Veterans Affairs (VA) Maintaining Implementation through Dynamic Adaptations (MIDAS) Quality Enhancement Research Initiative (QUERI) program was funded as a series of trials to test multi-component implementation strategies to sustain optimal use of three EBPs: 1) a deprescribing approach intended to reduce inappropriate polypharmacy; 2) appropriate dosing and drug selection of direct-acting anticoagulant medications (DOACs); and 3) use of cognitive behavioral therapy as first-line treatment for insomnia before pharmacologic treatment. We describe the design and methods for a harmonized series of cluster-randomized control trials comparing two implementation strategies.
Methods
For each trial, we will recruit 8–12 clinics (24–36 total). All will have access to a clinical dashboard that flags patients who may benefit from the target EBP at that clinic and provider. For each trial, clinics will be randomized to one of two implementation strategies to improve use of the EBPs: 1) individual-level academic detailing (AD); or 2) AD plus the team-based Learn. Engage. Act. Process. (LEAP) quality improvement (QI) learning program. The primary outcomes will be operationalized across the three trials as a patient-level dichotomous response (yes/no) indicating patients with potentially inappropriate care among those who may benefit from the EBP. This outcome will be computed using month-by-month administrative data. The dependent variable will be a unified variable representing clinic-level percent of potentially inappropriate care using generalized estimating equations (GEE) at months 13–36 post-baseline.
Discussion
MIDAS QUERI trials will focus on fostering sustained use of EBPs that previously had targeted but incomplete implementation. Our implementation approaches are designed to engage frontline clinicians in a dynamic optimization process that integrates use of actionable clinical dashboard data and making incremental changes, designed to be feasible within busy clinical settings.
Trial registration
ClinicalTrials.gov: NCT05065502. Registered October 4, 2021 – Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT05065502
“I am not shy anymore”: A Qualitative Study of the Impact of an Interactive mHealth Intervention on Sexual Health Knowledge, Attitudes, and Behaviors of South African Adolescents with Perinatal HIV
Authors: Bergam Scarlett , Sibaya Thobekile , Ndlela Nompumelelo , Kuzwayo Mpume , Fomo Messaline , Goldstein Madeleine H , Marconi Vincent C. , Haberer Jessica E. , Archary Moherndran , Zanoni Brian C. 
Published: March 2022

Abstract
Background: South Africa has the highest burden of adolescents with perinatally-acquired HIV (APHIV) in the world. APHIV in South Africa have limited access to sexual and reproductive health (SRH) education and services specific to their HIV status. When lacking comprehensive SRH education, APHIV are prone to sexual risk behaviors that can lead to unintended pregnancy, sexually transmitted infections, and HIV transmission. The use of mHealth interventions has been shown to deliver information, foster social support, and improve decision-making skills. In this study, we evaluate how an mHealth intervention influences sexual health knowledge and behaviors in APHIV. Methods: We purposively enrolled adolescents from the intervention arm of a randomized clinical trial assessing a multi-module, moderated WhatsApp-based intervention—Interactive Transition Support for Adolescents Living with HIV (InTSHA)—within a government supported clinic in KwaMashu, an urban township of KwaZulu-Natal, South Africa. We conducted in-depth interviews based on World Health Organization guidelines for asking adolescents about SRH. We thematically analyzed data through an iterative, team-based coding approach combining deductive and inductive elements to contextualize SRH attitudes, knowledge, and behaviors before and after receiving the InTSHA intervention.Results: Of the 21 participants, 13 (61.9%) were female and the mean age was 16.6 years. Most participants reported first learning about SRH as young teenagers in school through non-targeted and negative ways, seeking clarification through peers and the internet rather than clinicians or caregivers. Participants reported that InTSHA provided a holistic and destigmatizing perspective on relationships, gender, and sexuality specific to growing up with HIV in South Africa. They praised the ability to give and receive information from peers in a moderated setting through the mHealth intervention, building their confidence, decision-making skills, and communication with partners and caregivers throughout their everyday lives. Despite reporting some technological challenges, adolescents agreed that InTSHA was convenient, confidential, and user-friendly.Conclusions: South African APHIV receive incomplete and conflicting sexual education from peers, caregivers, teachers, and technology that can be supplemented by mHealth curricula targeted for the unique needs of APHIV. Future, scaled-up mHealth interventions can destigmatize SRH by expanding access to sexual education and peer support, supplementing adolescents’ existing SRH education.
Synthesis and Antitumor Activity Evaluation in Vitro of 4-aminoquinazoline Derivatives Containing 1,3,4-thiadiazole
Authors: Si Xiaojie , Dai Honglin , Gao Chao , Wang Hao , Chi Lingling , Wang Zhangjie , Zhang Luye , Li Erdong , Zheng Jiaxin , Ke Yu , Liu Hongmin , Zhang Qiurong 
Published: March 2022

Abstract
In order to search for new antitumor drugs with high efficiency and low toxicity, a series of novel 4-aminoquinazoline derivatives containing 1,3,4-thiadiazole group were designed, synthesized and evaluated for antiproliferative activity against four human cancer cell lines (H1975, PC-3, MCF-7 and HGC-27) using MTT assay in vitro. Among them, compound N-(5-((3,5-dichlorobenzyl)thio)-1,3,4thiadiazol-2-yl)-2-((4-(phenylamino)quinazolin-2-yl)thio)acetamide ( 15o ) showed good anti-tumor proliferation activity against four tested cancer cell lines, with IC 50 values of 1.96±0.15μM to PC-3 cell. The antitumor activity was significantly better than that of gefitinib. Further mechanism studies showed that compound 15o inhibited the migration ability of PC-3 tumor cells in a concentration dependent and time-dependent manner, and blocked the cell cycle in S phase. At the same time, cell cloning experiment further proved that compound 15o significantly inhibited the colony formation of PC-3 cells, The inhibition rate was as high as 92% at 2.0 μM.