bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overexpression of NAF-1 ameliorates Ischemic Stroke in rats by inhibiting PINK1/Parkin-mediated mitophagy
Authors: Fan Xiaomei , Wu Yu , Deng Ling , Zuo Tianrui , Yang Shaonan , Jiang Lu , Hu Qingwen , Chen Sha , Dong Zhi 
Published: August 2022

AbstractIschemic stroke (IS) has a high mortality and disability rate worldwide. NAF-1 is involved in the occurrence and development of nervous system diseases, but its involvement in the pathophysiology of IS is unclear. In this study, we investigated the role of NAF-1 in IS. Middle cerebral artery occlusion and reperfusion in Sprague-Dawley rats was used as an in vivo model of IS. Moreover, oxygen-glucose deprivation and reoxygenation of PC12 cells was used for in vitro study. Intracellular NAF-1 protein expression was influenced by LV-NAF-1 or siRNA. Quantitative real-time PCR and western blot analysis showed that NAF-1 was significantly downregulated following IS. Overexpression of NAF-1 reduced mitophagy in PC12 cells, and it alleviated tissue damage in vivo in rats and cell injury in vitro. In contrast, knockdown of NAF-1 increased mitophagy and worsened cell damage. These findings suggest that NAF-1 may have potential as a therapeutic target for IS.
Photocatalytic antiviral activity of zinc hydroxide for H1N1 virus under weak visible light
Authors: Ouyang Feng , Ren Zhaoyong , Liu Jingyuan , Li Hangliang , Gong Zhengya , Fan Youhua , Zha Xiaoxiong , Cao Gang , Bharti Bandna 
Published: August 2022

Abstract
Viral infections mainly occur in indoor environments, it is suggested that visible light-sensitive antiviral photocatalyst is highly desired. Here we developed a photocatalysis system based on zinc hydroxide (Zn(OH)2) to efficiently generate antiviral radicals on mask surface under weak visible light. The weak visible light induced the Zn(OH)2 photocatalysis and completed the inactivation of H1N1 virus for short time. In addition, the inactivating efficiency was improved greatly by adding a natural washing agent layer. Our system could inactivate H1N1 influenza virus completely rapidly under the irradiation of weak visible light. The discovery will open up a new research field, and enrich and promote the development of photocatalysis theory and practice.
Performance of Semi-Distributed Hydrological Models in Stream Flow Simulation
Authors: Sime Chala Hailu 
Published: August 2022

Abstract
Hydrological measurements are vital for Water Resources Planning and Management. Modeling rainfall-runoff may be used to understand the impact of future hydrological changes such as flooding, soil loss, and sedimentation effect on lakes and reservoirs for irrigation and hydropower. But the difficult one is the selection of the best models. All hydrological models may not be equally performed due to being influenced by input data and over models system that will be used for the analysis. Therefore, two hydrological models; Soil and Water Assessment Tool (SWAT), and Hydrologic Engineering Centers Hydrological Modeling System (HEC-HMS) models to simulate rainfall runoff. These models were calibrated and validated using daily observed streamflow data. The R2 and NSE were used to check the performance of the models and the result indicates that during HEC-HMS model calibration and validation, R2 of 0.6 and 0.61, NSE of 0.55 and 0.53, generated respectively. During the SWAT model accuracy assessment, the values of model performance indicators were R2 of 0.69 and 0.68, NSE of 0.58 and 0.52 for calibration and validation respectively. This indicates both SWAT and HEC-HMS models have been satisfied in streamflow simulations. The SWAT model overestimated the daily streamflow more than the observed and HEC-HMS simulated streamflow. These models overestimated peak streamflow during both the calibration and validation period. The curve number grid generated by HEC-GeoHMS was slightly lower than the curve number simulated by the SWAT model.
Possible benefit of intra articular ozone in advanced osteonecrosis of the knee: two case reports.
Authors: Fernández-Cuadros Marcos Edgar , Pérez-Moro Olga Susana , de Cía Javier Rodríguez , Albaladejo-Florín María Jesús 
Published: August 2022

Abstract
The knee is the second most common site of osteonecrosis (ON) after the hip. Three different entities are described: a) spontaneous ON; b) secondary ON; c) post-arthroscopy ON. In spontaneous ON the etiology is attributed to subchondral insufficiency fractures and to avascular necrosis due to ischemic events. Diagnosis is based on clinical and radiological basis (radiography, bone scan scintigraphy and MRI). Koshino´s radiological classification grades severity and guides in the management. Conservative management includes protected weight bearing, drugs (NSAIDs, bisphosphonates, D vitamin, calcium, prostaglandin I-2, corticosteroids, hyaluronic acid), physiotherapy (laser, pulsed electromagnetic fields), and hyperbaric oxygen therapy. Surgical treatment is deserved for advanced stages or if conservative treatment failed. In pre-collapse Stage, joint preserving procedures are expected; on the contrary, in subchondral collapse stages, joint arthroplasty is required. We present for the first time in literature the beneficial effect of intra articular ozone in the management of two cases of advanced ON of the knee.
Flexible non-parametric regression models for compositional response data with zeros
Authors: Tsagris Michail , Alenazi Abdulaziz , Stewart Connie Connie 
Published: August 2022

Abstract
Compositional data arise in many real-life applications and versatile methods for properly analyzing this type of data in the regression context are needed. When parametric assumptions do not hold or are difficult to verify, non-parametric regression models can provide a convenient alternative method for prediction. To this end, we consider an extension to the classical k--NN regression, termed α--k--NN regression, that yields a highly flexible non-parametric regression model for compositional data through the use of the α-transformation. Our model is further extended to the α--kernel regression by adopting the Nadaraya-Watson estimator. Unlike many of the recommended regression models for compositional data, zeros values (which commonly occur in practice) are not problematic and they can be incorporated into the proposed models without modification. Extensive simulation studies and real-life data analyses highlight the advantage of using these non-parametric regressions for complex relationships between the compositional response data and Euclidean predictor variables. Both suggest that α--k--NN and α-kernel regressions can lead to more accurate predictions compared to current regression models which assume a, sometimes restrictive, parametric relationship with the predictor variables. In addition, the α--k--NN regression, in contrast to current regression techniques, enjoys a high computational efficiency rendering it highly attractive for use with large scale, massive, or big data.
Multiple Sclerosis and risk of eight Adverse Events in Pregnancy: a Mendelian Randomization study
Authors: Tu Hengjia 
Published: August 2022

Abstract
Background
Observational studies have found an association between multiple sclerosis (MS) and some adverse events in pregnancy, but the causal effect between them is unclear.
Methods
Using data from large-scale genome-wide association studies (GWAS), we performed two-sample Mendelian randomization (MR) analysis to comprehensively assess the causal relationship between MS and the risk of eight adverse events in pregnancy (gestational hypertension, diabetes mellitus in pregnancy, ectopic pregnancy, mental disorders, hemorrhage in pregnancy, intrahepatic cholestasis of pregnancy, infections of genitourinary tract in pregnancy, and postpartum hemorrhage).
Results
MR analysis found that MS significantly reduces the risk of diabetes mellitus in pregnancy [OR = 0.8718186, 95%CI (0.8298085, 0.9159556), P < 0.0001] and intrahepatic cholestasis of pregnancy [OR = 0.8813462, 95%CI (0.8052561, 0.9646262), P = 0.0061]. However, the causal effect of MS on the other six adverse events (gestational hypertension, ectopic pregnancy, mental disorders, hemorrhage in pregnancy, infections of genitourinary tract in pregnancy, and postpartum hemorrhage) was not statistically significant.
Conclusion
We found that MS significantly reduced the risk of diabetes mellitus in pregnancy and intrahepatic cholestasis of pregnancy, and the causal effect of MS on other six adverse events (gestational hypertension, ectopic pregnancy, mental disorders, hemorrhage in pregnancy, infections of genitourinary tract in pregnancy, and postpartum hemorrhage) is unclear.
Artificial bee colony with predator effect algorithm for PID controller tuning
Authors: Singh Nirbhow Jap , Chopra Vikram , Pandey Sandeep , Singh Shakti 
Published: August 2022

Abstract
This paper proposed a novel artificial bee colony with predation effect (ABCPE) algorithm for tuning a proportional integral derivative (PID) controller. The mathematical model of ABCPE algorithm to introduce predator effect in the foraging behavior of artificial bees colony algorithm has been formulated. The proposed algorithm has been tested on tuning problems of different process models. The simulation results reveal that the closedloop responses are relatively fast and non-oscillatory as compared to the Ziegler-Nichols criteria. Further, the results obtained using ABCPE are also compared with other evolutionary algorithms. The exhaustive analysis shows that the ABCPE based solution approach leads to a set of tuning parameters having smaller overshoot, less setting time and rise time compared to other solution approaches. The stability analysis using Nichols plot reveals that the phase margin of proposed algorithm is higher as compared to other tuning methods.
A Novel Ferroptosis-related Gene Signature for Prognosis Prediction in Glioma
Authors: Lan Tian , Wu Die , Quan Wei , Yu Donghu , Li Sheng , Yao Jie , Li Zhi-Qiang 
Published: August 2022

Abstract
Background
Glioma is a lethal brain tumor characterized by its invasive nature, fast growth, and malignant recurrence. Despite aggressive surgical resection, concomitant concurrent radiation, and chemotherapy, the overall survival (OS) of patients with glioma remains low. Ferroptosis is a unique modality that regulates programmed cell death and is associated with multiple steps of tumorigenesis in a variety of tumors. As ferroptosis is an oxidative-stress-induced form of cell death and is related to the intracellular iron level that is intricately linked to cell metabolism, cancer cells may have a higher proclivity for it.
Methods
Genes relevant to ferroptosis were retrieved, and differential analysis was performed, followed by prognosis-related univariate and multivariate Cox regression analyses. A ferroptosis-involving model was also identified. Each sample’s risk score was statistically weighted by gene expression and stratified into high-risk and low-risk groups based on the cut-off value of the ROC curve. GO, KEGG, and GSVA analyses were used to detect probable biological functions and signaling pathways. All independent risk factors were included to build nomograms, and their accuracy and practicability were tested using the concordance index (C-index) and ROC curves. Immune cell infiltration was quantified using CIBERSORT software. Drug response and tumor mutation burden (TMB) were used to verify the effectiveness of the clinical use of immune-targeted therapy.
Results
The patient samples were stratified into two risk groups based on a four-gene signature. The high-risk group had poorer overall survival. The results of the functional analysis indicated that the extracellular matrix-related biological and interferon-gamma-mediated signaling pathway functions were enriched in the high-risk group, and multiple immune pathways were saturated in the GSVA analysis. The infiltration of immunocytes differed between the two groups. At multiple immune checkpoints, the risk score showed a strong positive correlation. The analysis of drug treatment response and TMB showed that the high-risk group had a better treatment response and better curative effect on immune target therapy. The CNV data analysis showed a correlation between the four genes in glioma and different CNV subtypes related to OS in glioma. Besides, we compared the published signatures of ferroptosis-related genes and found that our model performed well in evaluating glioma patients' prognosis in the new WHO CNS5 classification.
Conclusions
A novel ferroptosis-related gene signature, which can classify glioma patients into subgroups, can be used for prognostic prediction in glioma. The four-gene model in the clinical application could serve as a potential method to assess glioma patients' prognosis and response to therapy.
Improving the literacy quality of public communication Covid-19 pandemic madrasah-based educational institutions through digital skills
Authors: Hermansah Tantan 
Published: August 2022

Purpose – This article aims to describe the quality of communication literacy of the Covid-19 pandemic in madrasah-based educational institutions in the City and Regency of Bogor.Method - This study uses qualitative research with a descriptive analysis approach through direct field observations and Focus Group Discussions (FGD). The subjects in the study were six (6) Covid 19 Madrasah Task Forces in the City and District of Bogor.Result - The results of this service activity show that it is necessary to increase the capacity of each Madrasa Covid-19 Task Force through training and assistance and increasing understanding and communication skills so that the public gets a clear, firm, and definite understanding.Implication – the Task Force was then assisted because it was in the context of community development, so the desired process was by the planning. Lastly is monitoring and evaluation so community empowerment activities can be improved if there are still deficiencies.Originality - This research is based on improving the communication literacy quality of the Covid-19 pandemic 19 madrasa-based educational institutions through visual products to be strategic and important.***Tujuan – Tujuan dari pemberdayaan masyarakat ini adalah untuk menjelaskan gambaran kualitas literasi komunikasi pandemi Covid-19 di lembaga pendidikan berbasis madrasah di Kota dan Kabupaten Bogor.Metode – Metode dalam penelitian ini menggunakan jenis penelitian kualitatif dengan pendekatan analisis deskriptif melalui observasi lapangan secara langsung dan Focus Group Discussion (FGD). Subyek dalam penelitian ini adalah enam (6) Satgas Covid 19 Madrasah di Kota dan Kabupaten Bogor.Hasil - Hasil kegiatan pengabdian ini menunjukkan perlunya peningkatan kapasitas masing-masing Satgas Covid-19 Madrasah melalui pelatihan dan pendampingan serta peningkatan pemahaman dan keterampilan komunikasi agar masyarakat mendapatkan pemahaman yang jelas, tegas dan pasti.Implikasi – Satgas kemudian diberikan pendampingan, karena dalam rangka pengembangan masyarakat sehingga proses yang diinginkan sesuai dengan perencanaan. Terakhir adalah monitoring dan evaluasi agar kegiatan pemberdayaan masyarakat dapat ditingkatkan jika masih terdapat kekurangan.Orisinalitas - Penelitian ini dilatarbelakangi oleh peningkatan kualitas literasi komunikasi lembaga pendidikan berbasis madrasah 19 pandemi Covid-19 melalui produk visual menjadi strategis dan penting.
Accounting for Iranian EFL Teachers' Burnout: Educational Beliefs and Teacher Self-Disclosure in Focus
Authors: Ayatollahi Mohammad Ali , Nemati Ali Reza , Al Khaiyali Al Tiyb Suliman 
Published: August 2022

Teaching is considered a high-risk profession for suffering from burnout syndrome. Burnout syndrome not only affects the person who suffers from it, but also everyone around them, e.g., family, friends, co-workers, students and parents. The main purpose of this study was to find the correlates of burnout in EFL teachers. Thus, it was conducted to investigate any probable relationship between Iranian EFL teachers’ educational belief and their tendency to self-disclose with their likelihood of suffering from burnout. The research instruments were The Teacher Self-Disclosure Scale (Cayanus and Martin, 2008), Maslach Burnout Inventory (MBI-ES) (Maslach and Jackson, 1981), and Teachers' Educational Belief Questionnaire (Chan Elliot, 2004). The participants were 98 EFL teachers selected from 25 private language schools in Shiraz, Iran. Descriptive statistics, Cronbach Alpha coefficients, and Person Product-Moment Correlation Coefficient were used to answer this research questions. Analyzing the data collected through the questionnaires indicated that there was a positive correlation between some dimensions of teacher burnout and those of teachers’ constructive or traditional beliefs. Thus, ‘lack of personal achievement’ and ‘constructive beliefs’, ‘emotional exhaustion’ and ‘depersonalization’ and teachers’ traditional beliefs were positively correlated. Conversely, a negative correlation was identified between ‘lack of personal achievement’ and teachers’ traditional beliefs. Likewise, ‘emotional exhaustion’ and ‘depersonalization’ on the burnout scale were correlated with teachers’ constructive beliefs. However, no significant correlation was observed between teachers’ neutral beliefs and any dimensions of the burnout scale. Moreover, teacher self-disclosure quantity and negativity were found to be corelated with ‘emotional exhaustion’ and ‘depersonalization’ on the burnout scale.
Minimization of halogenated disinfection by-product precursors by Al-based electrocoagulation–flotation (ECF) toward cyanobacteria-laden water
Authors: Lin Jr-Lin , Sidik Fahrudin , Kang Shyh-Fang 
Published: August 2022

Abstract
The presence of toxic algae, such as Microcystis aeruginosa (MA), in drinking water treatment plants (DWTPs) would contribute to algal organic matter (AOM) as precursors toward disinfection by-products (DBPs). Electrocoagulation–flotation (ECF) has shown promising performance in minimizing algal cells from water and dissolved AOM. This study aimed to investigate the effect of current density (CD) and pH on alumina (Al)-based ECF for removing MA cell and DBPs precursors from cyanobacteria-laden water. The performance of Al-based ECF was evaluated at various CD and pH conditions within 20 min. In addition, the total halogenated DBPs formation of the treated suspension after ECF was quantified. At pH 8, the ECF process with 5 mA/cm2 exhibits the most significant reductions in MA cell and soluble AOM, accounting for 97 and 56%, respectively. Additionally, the precursors of trihalomethanes (THMs) and haloketones (HKs) can be effectively removed with flotation despite their significant release at EC. The tremendous reduction of humic acid-like (HAL) substances in extracellular organic matter (EOM) fraction by ECF leads to the minimized THMs formation potential. In summary, Al-based ECF at pH 8 is effective to remove cyanobacteria and minimize the precursors of regulated THMs along with an insignificant reduction in regulated haloacetic acids (HAAs) precursors.
Recent Advances in Base-assisted Michael Addition Reactions
Authors: Mamatha Jyothi Rekala Shalini , Sripathi Mydhili P. , Thirupathi Ponnaboina 
Published: August 2022

Abstract:
The Michael addition is an important, highly efficient, and atom-economical method for the diastereoselective and enantioselective C-C bond formation. MA used in the synthesis of natural products and drugs is tandem sequenced reactions. An important tandem sequence of Michael and Aldol additions is the Robinson annulation. MA is a versatile reaction employed for efficient bond formation between electron-poor olefins as Michael acceptors with varied nucleophiles as Michael donors. Apart from being involved in C-C bond formation, MA is also employed in the formation of C-X bond (X=O, N, S, P etc.) giving rise oxa-, aza-, thia-, phospha-Michael addition products. In recent years many articles have been published on MA. The mechanism of MA gives an insight into the reaction is initiated by the base. The present review provides comprehensive information on recent advancements in base-assisted Michael addition reactions including varied organic and inorganic bases, such as 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), 1,4-Diazabicyclo[2.2.2]octane (DABCO), 4-dimethylaminopyridine (DMAP), triethylamine (Et3N), tributylamine (Bu3N), N,N-diisopropylethylamine (DIEPA), diethylamine (NHEt2), guanidine derivatives, and bifunctional thiourea. A variety of inorganic bases including metal alkoxides, metal acetates, metal hydroxides, metal hydrides, metal carbonates, metal halides, and triphenylphosphine (TPP) can also be successfully used in Michael reactions.
Graft Copolymers of Polysaccharide: Synthesis Methodology and
Biomedical Applications in Tissue Engineering
Authors: Malviya Rishabha , Singh Arun Kumar 
Published: August 2022

Abstract:
A polymer is a macromolecule that has a significant number of repeating units. It is
possible to modify the architecture of a polymer via grafting, bridging, mixing, or generating composites.
There are several uses for using natural polymers in culinary and medicinal applications.
Polymeric materials became appealing because of their low density and ability to incorporate
properties of their constituent constituents. High-energy accelerated electrons from the plasma
induce chemical bond breaking in the polymeric structure, resulting in the generation of macromolecule
radicals and graft copolymerization. Polymer grafting has become an important aspect of
the formulation development process. When polymer functional groups are changed, a wide variety
of desirable and unwanted properties can be added or removed. It can be concluded from the
findings of the literature survey that graft copolymers of polysaccharides have significant
biomedical applications including drug delivery and tissue engineering applications.
Association between Chlamydia trachomatis Infection and Male Infertility:
A Systematic Review and Meta-Analysis
Authors: Keikha Masoud , Hosseininasab-Nodoushan Seyed-Abolfazl , Sahebkar Amirhossein 
Published: August 2022

Background:
Chlamydia trachomatis infection is one of the most common sexually
transmitted diseases. There is widespread evidence in recent years that indicate C. trachomatis
infection plays a role in sperm dysfunction and poor sperm quality. However, some controversial
documents have argued the role of infection with this bacterium in male infertility.

Methods:
A full comprehensive electronic search was performed using the online databases Web
of Science, PubMed, Scopus, Embase, and Google Scholar, without considering the time limits.

Results:
In the present study, 56 articles were finally found to be eligible. The prevalence of C.
trachomatis infection in the infertile males was estimated at 20.6% (19.8-21.5 with 95% CIs; p-
Value: 0.01; I2: 97.77; Q-Value: 237.8; p-Value: 0.01; Begg's p-Value: 0.09; Egger's p-Value:
0.01) in overall. We have also shown that infection with C. trachomatis can significantly increase
the risk of infertility in men (OR: 2.28; 1.90-2.72 with 95% CIs; p-Value: 0.001; I2: 81.61; QValue:
59.81; p-Value: 0.01; Begg's p-Value: 0.73; Egger's p-Value: 0.61).

Conclusion:
We showed a high prevalence of C. trachomatis in the sperm and semen samples of
infertile men, and C. trachomatis infection is associated with a significantly higher risk of infertility
in men.