bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Forced Response and Decadal Predictability of the North Atlantic Oscillation: Nonstationary and Fragile Skills
Authors: Christiansen Bo , Yang Shuting , Matte Dominic 
Published: May 2022

Abstract
We investigate the forced response of the North Atlantic Oscillation (NAO)—calculated as the ensemble mean—in different large ensembles of climate models including simulations with historical forcings and initialized decadal hindcasts. The forced NAO in the CMIP6 historical ensemble correlates significantly with observations after 1970. However, the forced NAO shows an apparent nonstationarity with significant correlations to observations only in the period after 1970 and in the period before 1890. We demonstrate that such apparent nonstationarity can be due to chance even when models and observations are independent. For the period after 1970 the correlation to the observed NAO continues to increase while the amplitude of the forced signal continues to decrease—although both with some signs of saturation—when the ensemble size grows. This behavior can be explained by a simple statistical model assuming a very small signal-to-noise ratio in the models. We find only rather weak evidence that initialization improves the skill of the NAO on decadal time scales. The NAO in the historical ensembles including only natural forcings, well-mixed greenhouse gases, or anthropogenic aerosols show skill that is not significantly different from zero. The same holds for a large single-model ensemble. The skills of these ensembles, except for the well-mixed greenhouse gas ensemble, are also significantly different from the skill of the larger full historical ensemble even though their ensemble sizes are smaller. Taken together, our results challenge the possibility of useful NAO predictions on decadal time scales.
The Statistics of Oceanic Turbulence Measurements. Part I: Shear Variance and Dissipation Rates
Authors: Lueck Rolf G. 
Published: May 2022

Abstract
An empirically derived statistic is used to estimate the confidence interval of a dissipation estimate that uses a finite amount of shear data. Four collocated shear probes, mounted on a bottom anchored float, are used to measure the rate of dissipation of turbulence kinetic energy ϵ at a height of 15 m above the bottom in a 55 m deep tidal channel. One pair of probes measures ∂w/∂x while the other measures ∂υ/∂x, where w and υ are the vertical and lateral velocity. The shear-probe signals are converted into a regularly resampled space series to permit the rate of dissipation to be estimated directly from the variance of the shear using (and similarly for the υ component), for averaging lengths, L ranging from 1 to 104 Kolmogorov lengths. While the rate of dissipation fluctuates by more than a factor of 100, the fluctuations of the differences of between pairs of probes are stationary, zero mean, and distributed normally for averaging lengths of L = ∼30 to 104 Kolmogorov lengths. The variance of the differences, , scales as L−7/9, independent of stratification for buoyancy Reynolds numbers larger than ∼600, and for dissipation rates from ∼10−10 to ∼10−5 W kg−1. The variance decreases more slowly than L−1 because the averaging is done in linear space while the variance is evaluated in logarithmic space. This statistic provides the confidence interval of an ϵ estimate such as the 95% interval . This result also applies to the traditional ϵ estimates that are made by way of spectral integration, after L is adjusted for the truncation of the shear spectrum.

Significance Statement
The results reported here can be used to estimate the statistical uncertainty of a dissipation estimate that is derived from a finite length of turbulence shear data.
Radar Reflectivity–Based Model Initialization Using Specified Latent Heating (Radar-LHI) within a Diabatic Digital Filter or Pre-Forecast Integration
Authors: Weygandt Stephen S. , Benjamin Stanley G. , Hu Ming , Alexander Curtis R. , Smirnova Tatiana G. , James Eric P. 
Published: May 2022

Abstract
A technique for model initialization using three-dimensional radar reflectivity data has been developed and applied within the NOAA 13-km Rapid Refresh (RAP) and 3-km High-Resolution Rapid Refresh (HRRR) regional forecast systems. This technique enabled the first assimilation of radar reflectivity data for operational NOAA forecast models, critical especially for more accurate short-range prediction of convective storms. For the RAP, the technique uses a diabatic digital filter initialization (DFI) procedure originally deployed to control initial inertial gravity wave noise. Within the forward-model integration portion of diabatic DFI, temperature tendencies obtained from the model cloud/precipitation processes are replaced by specified latent heating–based temperature tendencies derived from the three-dimensional radar reflectivity data, where available. To further refine initial conditions for the convection-allowing HRRR model, a similar procedure is used in the HRRR, but without DFI. Both of these procedures, together called the “Radar-LHI” (latent heating initialization) technique, have been essential for initialization of ongoing precipitation systems, especially convective systems, within all NOAA operational versions of the 13-km RAP and 3-km HRRR models extending through the latest implementation upgrade at NCEP in 2020. Application of the latent heat–derived temperature tendency induces a vertical circulation with low-level convergence and upper-level divergence in precipitation systems. Retrospective tests of the Radar-LHI technique show significant improvement in short-range (0–6 h) precipitation system forecasts, as revealed by reflectivity verification scores. Results presented document the impact on HRRR reflectivity forecasts of the radar reflectivity initialization technique applied to the RAP alone, HRRR alone, and both the RAP and HRRR.

Significance Statement
The large forecast uncertainty of convective situations, even at short lead times, coupled with the hazardous weather they produce, makes convective storm prediction one of the most significant short-range forecast challenges confronting the operational numerical weather prediction community. Prediction of heavy precipitation events also requires accurate initialization of precipitation systems. An innovative assimilation technique using radar reflectivity data to initialize NOAA operational weather prediction models is described. This technique, which uses latent heating specified from radar reflectivity (and can accommodate lightning data and other convection/precipitation indicators), was first implemented in 2009 at NOAA/NCEP and continues to be used in 2022 in the NCEP-operational RAP and HRRR models, making it a backbone of the NOAA rapidly updated numerical weather prediction capability.
Lower Extremity Injury Rates on Artificial Turf Versus Natural Grass Playing Surfaces: A Systematic Review
Authors: Gould Heath P. , Lostetter Stephen J. , Samuelson Eric R. , Guyton Gregory P. 
Published: May 2022

Background: No study has provided a comprehensive systematic review of sports injuries on artificial turf versus natural grass. Purpose: To comprehensively examine the risk of overall injuries and multiple types of lower extremity injuries across all sports, all levels of competition, and on both old-generation and new-generation artificial turf. Study Design: Systematic review; Level of evidence, 3. Methods: A systematic review of the English-language literature was performed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. All included articles compared overall injury rates or lower extremity (hip, knee, or foot and ankle) injury rates on artificial turf and natural grass. All sports, levels of competition, and turf types were included. Studies were excluded if they did not include overall injury rates or lower extremity injury rates. Because of the heterogeneity of the included studies, no attempt was made to aggregate risk ratios to conduct a quantitative meta-analysis. Results: A total of 53 articles published between 1972 and 2020 were identified for study inclusion. Most studies on new-generation turf (13/18 articles) found similar overall injury rates between playing surfaces. When individual anatomic injury locations were analyzed, the greatest proportion of articles reported a higher foot and ankle injury rate on artificial turf compared with natural grass, both with old-generation (3/4 articles) and new-generation (9/19 articles) turf. Similar knee and hip injury rates were reported between playing surfaces for soccer athletes on new-generation turf, but football players, particularly those at high levels of competition, were more likely to sustain a knee injury on artificial turf than on natural grass. Conclusion: The available body of literature suggests a higher rate of foot and ankle injuries on artificial turf, both old-generation and new-generation turf, compared with natural grass. High-quality studies also suggest that the rates of knee injuries and hip injuries are similar between playing surfaces, although elite-level football athletes may be more predisposed to knee injuries on artificial turf compared with natural grass. Only a few articles in the literature reported a higher overall injury rate on natural grass compared with artificial turf, and all of these studies received financial support from the artificial turf industry.
Association of baseline parameters with year 0 and year 1 acute exacerbations in male patients with chronic obstructive pulmonary disease
Authors: Chang Yu-Ping , Chen Yu-Mu , Chang Ya-Chun , Liu Shih-Feng , Fang Wen-Feng , Chao Tung-Ying , Wu Chao-Chien , Chang Huang-Chih , Lin Meng-Chih , Chen Yung-Che 
Published: May 2022

Objectives Acute exacerbations (AEs) of chronic obstructive pulmonary disease (COPD) can affect health status, hospitalization and readmission rates, and disease progression. This study aimed to identify independent markers associated with COPD AEs. Methods This study included male patients with COPD and collected data regarding their AEs and baseline clinical parameters. Results We included 149 male patients. Among them, 58 were included in the year 0 high-AE group and 91 in the low-AE group. Multivariate analysis revealed that the high-AE group had higher white blood cell count, lower serum albumin level, and post-bronchodilator (BD) forced expiratory volume in one second (FEV1) (%) with a combined receiver operating characteristic curve (ROC) of 0.721 ( p < 0.001). Additionally, 34 patients were included in the year 1 high-AE group and 70 in the low-AE group ( p < 0.001). Multivariate analysis revealed that the high-AE group had higher platelet count, positive asthma history, and lower pre-BD FEV1 (%) with a combined ROC of 0.782 ( p < 0.001). Conclusion In male patients with COPD, baseline white blood cell count, albumin level, and post-BD FEV1 (%) were correlated with year 0 AE; on the other hand, baseline platelet count, positive asthma history, and pre-BD FEV1 (%) were associated with year 1 AE.
Immunogenicity, safety, and antiphospholipid antibodies after SARS-CoV-2 vaccine in patients with primary antiphospholipid syndrome
Authors: Signorelli Flavio , Balbi Gustavo Guimarães Moreira , Aikawa Nadia E , Silva Clovis A , Kupa Léonard de Vinci Kanda , Medeiros-Ribeiro Ana C , Yuki Emily FN , Pasoto Sandra G , Saad Carla GS , Borba Eduardo F , Seguro Luciana Parente Costa , Pedrosa Tatiana , Oliveira Vitor Antonio de Angeli , Costa Ana Luisa Cerqueira de Sant’Ana , Ribeiro Carolina T , Santos Roseli Eliana Beseggio , Andrade Danieli Castro Oliveira , Bonfá Eloisa 
Published: May 2022

Objective Coronavirus disease 19 (COVID-19) has an increased risk of coagulopathy with high frequency of antiphospholipid antibodies (aPL). Recent reports of thrombosis associated with adenovirus-based vaccines raised concern that SARS-CoV-2 immunization in primary antiphospholipid syndrome (PAPS) patients may trigger clotting complications. Our objectives were to assess immunogenicity, safety, and aPL production in PAPS patients, after vaccinating with Sinovac-CoronaVac, an inactivated virus vaccine against COVID-19. Methods This prospective controlled phase-4 study of PAPS patients and a control group (CG) consisted of a two-dose Sinovac-CoronaVac (D0/D28) and blood collection before vaccination (D0), at D28 and 6 weeks after second dose (D69) for immunogenicity/aPL levels. Outcomes were seroconversion (SC) rates of anti-SARS-CoV-2 S1/S2 IgG and/or neutralizing antibodies (NAb) at D28/D69 in naïve participants. Safety and aPL production were also assessed. Results We included 44 PAPS patients (31 naïve) and 132 CG (108 naïve) with comparable age ( p=0.982) and sex ( p>0.999). At D69, both groups had high and comparable SC (83.9% vs. 93.5%, p=0.092), as well as NAb positivity (77.4% vs. 78.7%, p=0.440), and NAb-activity (64.3% vs. 60.9%, p=0.689). Thrombotic events up to 6 months or other moderate/severe side effects were not observed. PAPS patients remained with stable aPL levels throughout the study at D0 vs. D28 vs. D69: anticardiolipin (aCL) IgG ( p=0.058) and IgM ( p=0.091); anti-beta-2 glycoprotein I (aβ2GPI) IgG ( p=0.513) and IgM ( p=0.468). Conclusion We provided novel evidence that Sinovac-CoronaVac has high immunogenicity and safety profile in PAPS. Furthermore, Sinovac-CoronaVac did not trigger thrombosis nor induced changes in aPL production.
Trousseau’s syndrome in a non-small cell lung cancer patient aggravated by pembrolizumab
Authors: Zhao Lihong , Zheng Hong , Zhu Liqin , Jiang Ping 
Published: May 2022

Introduction We present a case of Trousseau’s syndrome in a non-small cell lung cancer patient recurrently aggravated by pembrolizumab. The adverse events related to immune checkpoint inhibitors (ICIs) on thrombogenesis remain unclear. Case report A 48-year-old woman was diagnosed with right lung adenocarcinoma (cT1bN3M1a, IVA) and with programmed cell death-1 positive. Brain magnetic resonance imaging (MRI) showed multiple asymptomatic bilateral cerebral infarctions as Trousseau’s syndrome. After the patient was administered pembrolizumab, bilateral cerebral infarctions were aggravated. Management and outcome Although the patient was given prophylactic anticoagulant therapy respectively before two doses of pembrolizumab, Trousseau’s syndrome still aggravated recurrently. Discussion Trousseau’s syndrome is rarely reported following the administration of ICIs. It is possible that pembrolizumab may trigger disorders of the coagulation–fibrinolysis system in cancer patients.
Rapid Superficial Vein Assessment (RaSuVA): A pre-procedural systematic evaluation of superficial veins to optimize venous catheterization in neonates
Authors: D’Andrea Vito , Prontera Giorgia , Pezza Lucilla , Barone Giovanni , Vento Giovanni , Pittiruti Mauro 
Published: May 2022

Background: Placement of peripheral intra-venous cannulas and epicutaneo-caval catheters is routinely performed in in Neonatal Intensive Care Unit (NICU), and both devices require visible superficial veins easy to cannulate. NICU patients are intrinsically characterized by poor and fragile vein asset, so that puncture and cannulation of superficial veins is often a challenge even for trained clinicians and cannulation frequently results in a stressful, painful, difficult procedure. Methods and results: Rapid Superficial Vein Assessment is meant to offer a systematic pre-procedural evaluation of all superficial veins of the newborn, so to allow a rational choice of the best insertion site, tailored on the single patient, and optimized for the specific type of venous access device. The superficial veins are examined systematically, both with and without NIR technology, exploring seven skin areas in the following order: (1) medial malleolus, (2) lateral malleolus, (3) retro-popliteal fossa, (4) back of the hand and wrist, (5) antecubital fossa, (6) anterior scalp surface, and (7) posterior scalp surface. Conclusions: The aim of the protocol is to increase the first attempt success rate and reduce the duration of the procedure, the number of attempts for single patient and possibly to limit complications, stress, and pain in neonates.
Implementing patient navigator programmes within a hospital setting in Toronto, Canada: A qualitative interview study
Authors: Kokorelias Kristina M , Gould Sarah , Das Gupta Tracey , Ziegler Naomi , Cass Dan , Hitzig Sander L 
Published: May 2022

Objectives: This study sought to identify the organisation and system level barriers and facilitators influencing the implementation of patient navigator programmes in one acute care hospital system in Toronto, Canada. Methods: A qualitative descriptive approach informed by the Consolidated Framework for Implementation Research. Data were collected using in-depth interviews and analysed thematically. Results: Thirty-eight individuals participated in interviews (17 community, 21 acute care hospital), including 24 frontline clinicians and 14 programme directors, health care leaders and managers. Implementation of patient navigator programmes was dependent on: (1) a clear consensus on the unique need for patient navigators; (2) champions to promote patient navigation; (3) programme ownership and accountability; (4) external system and organisational landscape and (5) implementation climate. Appropriate mechanisms of communication were found to have impacted each factor as a barrier or facilitator to programme implementation. Conclusion: Strategies for implementing patient navigator programmes into hospital clinical practice should include incorporating evidence to support the programme, considering mechanisms to enable collaborative communication, and the integration of frameworks to facilitate programme integration into the current practices within the organisation.
A 6-year retrospective review of psychiatric emergency service utilization by school-age children
Authors: Rana Gagandeep S , Nordsletten Ashley , Sivananthan Mauran , Hong Victor 
Published: May 2022

To explore utilization patterns and associated clinical factors of school-age children who present to a psychiatric emergency department. This was a 6-year retrospective chart review study of children 5–12 years of age who presented to a psychiatric emergency service from July 2012 to June 2018 ( n = 1654 patients). Demographic variables, clinical diagnoses, lifetime adverse events (physical abuse, sexual abuse, and bullying), and history of self-harm were documented for each visit. We performed a chi square analysis to identify association between demographic and clinical features with key outcomes. Increased service utilization as defined by inpatient psychiatric admission, recurrent visits, or increased length of stay were found in patients who were adopted, presented with suicidal ideation or self-harm behaviors, had a history of abuse, and had a diagnosis of depression or autism. Trends over the course of the study indicated a significantly increased percentage of patients presenting with suicidal ideation, bullying, and self-harm behaviors. The data add to the limited literature regarding school-age children with a psychiatric emergency. Increased emergency service utilization for certain subgroups of children and trends over the course of the study underscore the need for enhanced treatment options for individuals with certain demographic or clinical features, and increased outpatient, intermediate, and inpatient treatment options, as well as preventative care.
Procalcitonin kinetics following abdominal aortic surgery and its value for postoperative intestinal ischaemia detection
Authors: Novotny Tomas , Staffa Robert , Tomandl Josef , Krivka Tomas , Kruzliak Peter , Tomandlova Marie , Slaby Ondrej , Sponiar Jan , Caprnda Martin , Gaspar Ludovit , Rodrigo Luis , Mozos Ioana , Kubicek Lubos , Biros Ernest , Vlachovsky Robert , Radova Lenka , Konieczna Anna 
Published: May 2022

Objective The purpose of our study was to describe perioperative kinetics of procalcitonin (PCT) in patients undergoing aortic surgery, to compare the kinetics in the open abdominal aortic aneurysm (AAA) repair and aortobifemoral bypass for aortoiliac occlusive disease (AIOD), and to evaluate the ability of PCT to detect intestinal ischaemia. Methods A prospective non-randomized observational cohort study in 80 patients (62 men and 18 women) undergoing elective aortic surgery was performed. Serum PCT was measured at baseline and defined intraoperative and postoperative timepoints up to postoperative day 7. MRI contrast-enhanced imaging was used to detect intestinal ischaemia. Results The comparison of the AAA and AIOD cohort did not show any significant difference in PCT levels. Patients with intestinal ischaemia had higher serum PCT at multiple timepoints postoperatively. The most accurate timepoints for early diagnosis were postoperative day 3, followed by 24 h after declamping of the vascular reconstruction, and postoperative day 7. The sensitivity and negative predictive values were 100% in all mentioned timepoints. However, event at the best timepoint the specificity was 89% and the positive predictive value 43%. Conclusions Procalcitonin levels in the postoperative period at proper timepoints might help to detect postoperative intestinal ischaemia. The limitation of this marker is its low specificity for intestinal ischaemia and low positive predictive value. The highest value of this marker is that it can rule out this complication because normal PCT levels mean that intestinal ischaemia is very unlikely.
Prevalence and determinants of the involvement of married men in family planning services in Ethiopia: A systematic review and meta-analysis
Authors: Kassa Bekalu Getnet , Tenaw Lebeza Alemu , Ayele Alemu Degu , Tiruneh Gebrehiwot Ayalew 
Published: May 2022

Background: Male involvement in family planning includes not only using contraceptives but also encouraging and supporting their partners’ contraception needs and choices, encouraging peers to use family planning, and influencing policy to make male-related programs more conducive. In Ethiopia, the prevalence and associated factors of male involvement in family planning were highly inconsistent across studies. As a result, the goal of this study was to use a systematic review and meta-analysis to estimate the pooled prevalence of male involvement in family planning and its associated factors in Ethiopia. Methods: Electronic literature search using PubMed, Google Scholar, EMBASE, HINAR, Scopus, and Web of Sciences were performed without time restriction to identify the primary studies. Data were extracted using a pretested standardized data extraction format and analyzed using STATA 14 statistical software. A random-effect model was used to estimate the pooled prevalence of male involvement. Results: A total of 17 studies were included to give the pooled prevalence of male involvement in family planning in Ethiopia, which was 39.66% (95% confidence interval = 29.86, 49.45). Educational status (adjusted odds ratio = 1.99, 95% confidence interval = 1.26, 3.14), discussion of family planning with wife (adjusted odds ratio = 4.15, 95% confidence interval = 2.21, 7.80), knowledge (adjusted odds ratio = 1.83, 95% confidence interval = 1.26, 2.64), positive attitude about family planning (adjusted odds ratio = 2.57, 95% confidence interval = 1.70, 3.90), and approval of contraceptive use (adjusted odds ratio = 2.57, 95% confidence interval = 1.70, 3.90) were found to be significantly associated with involvement of men in family planning service. Conclusion: The overall prevalence of male involvement in family planning in Ethiopia was significantly low. Male involvement in family planning should be made available, accessible, and advocated for by government and non-governmental organizations, service providers, program planners, and stakeholders. In addition, to increase the role of men in the use of family planning services, a conducive environment for education, behavioral change, and open discussion about reproductive health issues is required.