bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bacteria and Antimicrobial Resistance in Children at Damascus Hospital
Authors: Kahal Fares , Mohsen Fatema , Helwani Ahmed , Bani Maher Al 
Published: January 2022

Abstract
Background

Antimicrobial resistance is the third top-ranking global causative of death.
Aims

The aim is to evaluate antimicrobial resistance and sensitivity to aid the assessment of the efficacy in Syrian management protocols.
Methods

A retrospective study was conducted to analyze children with positive culture results presenting with nosocomial or community-acquired infections in Damascus Hospital, Damascus, Syria.
Results

117 patients with 183 positive culture results were included in the study. The most antibiotic-resistant bacterium was Pseudomonas aeruginosa. The highest bacterial antibiotic resistance occurred with Ceftriaxone, Pseudomonas aeruginosa (89%), Escherichia coli (77%), Enterobacter (74%), and Proteus (42%). Staphylococcus sensitivity towards vancomycin was only 3%. The mortality was 19(16%), nosocomial infection 11(55%) and community infections 9(45%).
Conclusion

The efficacy of the remaining antibiotics to which the bacteria are sensitive must be maintained through rationalization of its use. Strict precautionary measures must be implemented to ban the illegal dispensation of antibiotics.
What is the impact of covid-19 pandemic era on Pregnant Women sero-positivity for Syphilis among women attending antenatal care in India and number of babies diagnosed with Congenital Syphilis?
Authors: Kumar Piyush 
Published: January 2022

Abstract
Sexually transmitted infections (STIs) still continue to be a major public health problem globally, affecting the quality of life as well as causing serious morbidity and mortality. STIs have a direct and significant impact on reproductive and child health. They can directly cause infertility, cancers as well as pregnancy complications, and indirectly affects individual economies. The information on the number of PW found to be sero positive for Syphilis among women attending antenatal care in India and number of babies diagnosed with Congenital Syphilis is collected from HMIS electronic records of MoHFW, Government of India with key objective to know about the impact of covid-19 era i.e. 2020 and 2021 on prevalence of syphilis by comparing it with the pre pandemic era of 2018 and 2019. I collected sero positivity data for Syphilis among women attending antenatal care in India and number of babies diagnosed with Congenital Syphilis across 36 states and union territories of India including all health facilities viz. public, private, rural, urban health facilities. The data is collected, observed and analyzed with Microsoft office software. Among 254705.2 averages per month number of PW (pregnant women) tested using POC test for Syphilis, 2144.4 averages per month were sero positive for Syphilis giving a sero-prevalence of 0.84% in 2021(Jan to May). Of 175579.75 averages per month number of PW tested using POC test for Syphilis, 855.58 averages per month were sero positive for Syphilis giving a sero-prevalence of 0.49% in 2020(Jan to Dec). Of 53313.66 averages per month number of PW tested using POC test for Syphilis, 419.33 averages per month were sero positive for Syphilis giving a sero-prevalence of 0.79% in 2019 (Jan to Dec). Of 11364.75averages per month number of PW tested using POC test for Syphilis, 339.08 averages per month were sero positive for Syphilis giving a sero-prevalence of 2.98% in 2018 (Jan to Dec).
The Turkish version of the İkigai-9 Scale: A validity and reliability study
Authors: Belice Tahir , Yıldırım Nejla Özkan , Gursoy Utkucan , Murakami Ikuko , Demir Ismail , Yüksel Arif , Akçiçek Selahattin Fehmi 
Published: January 2022

Abstract
The aim: İkigai, or well-being, has been associated with many positive outcomes in the physical and mental health of elderly people. In the present study, we conducted a validity and reliability study of the İkigai-9 scale in Turkish society and outlined its associations with facets of well-being.Methods: A translation, re-translation method was used to create linguistic equivalence of the İkigai-9 scale in the Turkish language. The correlations between the İkigai-9 Turkish version with the Warwick Edinburgh Mental Well-being Scale Short Form and the Depression Anxiety Stress Scale (DASS-21) were studied. Face-to-face interviews were conducted with volunteers regarding the scale. Data were saved in excel files and analyzed with SPSS (IBM SPSS for Windows, ver.24).Results: The findings confirmed the validity and reliability of the İkigai-9 Turkish version using 382 participants. The total scores on the İkigai-9 Turkish version were correlated positively with mental well-being and negatively correlated with depression, anxiety, and depression (p<0.05). Moreover, the total İkigai-9 Turkish version scores had a positive correlation with age (p<0.05) but did not differ according to gender (p>0.05).Conclusions: İkigai and studies related to the concept of mental well-being should be widened and expanded across nations. These studies could be beneficial to healthcare providers to attenuate the impact of suffering from various diseases. We present the İkigai-9 Turkish version for further study in both in the national and international contexts that healthcare workers could compare their results in other countries.
Effects of symmetry breaking of the structurally-disordered Hamiltonian ensembles on the anisotropic decoherence of qubits
Authors: Chen Hong-Bin 
Published: January 2022

Abstract
It is commonly known that the dephasing in open quantum systems is due to the establishment of bipartite correlations with ambient environments, which are typically difficult to be fully characterized. Recently, a new approach of average over disordered Hamiltonian ensemble is developed and shown to be capable of describing the nonclassicality of incoherent dynamics based on inferring the nonclassical nature of the correlations. Here we further extend the approach of Hamiltonian ensemble in the canonical form to the realm of structural disorder. Under the variable separation of the probability distribution within the Hamiltonian ensemble, the geometrical structure is easily visualized and can be characterized according to the degree of symmetry. We demonstrate four degrees and investigate the effects of different types of symmetry breaking on the incoherent dynamics. We show that these effects are easily understood from the emergences of additional terms in the master equations, leading to rather general master equations and, consequently, going beyond the previous frameworks of pure dephasing or isotropic depolarization.
Non-extraction camouflage treatment using extra-alveolar skeletal anchorage
Authors: Lee Young-Jun , Park Jae Hyun , Chang Na-Young , Lee Kang-Gyu , Chae Jong-Moon 
Published: January 2022

Abstract
A 23-year-old female patient with moderate crowding and a bilateral molar scissor-bite was successfully treated without tooth extraction. Extra-alveolar skeletal anchorage, involving a three-dimensional key plate in the maxilla and two miniscrews in the buccal shelf of the mandible, were used for distalisation, buccolingual uprighting, and the intrusion of molars by fixed orthodontic appliances. Cone-beam computed tomography was used to identify available posterior space for the distalisation and buccolingual correction of the molars in scissor-bite. The total treatment time was 24 months. Post-treatment results showed good occlusal relationships and smile aesthetics. Twelve-month post-treatment records demonstrated no significant relapse and a favourable facial balance.
The Sensitive Genes in Response to Various Metal Ion Stresses in the
Yeast Saccharomyces cerevisiae
Authors: Wang Xue , Lyu Keliang , Shi Kailun , Liu Chengkun , Lyu Zhiwen , Liu Dongwu 
Published: January 2022

Abstract:
Yeast Saccharomyces cerevisiae is a good eukaryotic model for studying the molecular mechanism of toxic metal ion stress. Numerous studies have been performed on the signal transduction induced by toxic metal ion stress. The physiological process of eukaryotic cells has been studied and various stress factors have been elucidated by constructing gene deletion library. Until now, the sensitivity and tolerance mechanism of yeast under metal ion stress have been widely studied. The sensitive genes induced by metal ion stress will provide a key foundation for studying the gene function of eukaryotic organisms. In addition, the functions of genes in response to metal ion stress mainly participate in regulating ion homeostasis, high glycerin pathway, vacuole protein separation pathway, cell wall integrity pathway, and cell autophagy. However, the interaction of these signal pathways and the detailed response mechanism need to be further studied in future. In addition, the technique of genomics and proteomics will be helpful for studying the detailed molecular mechanism induced by toxic metal ion stress. Thus, the sensitive genes related to various signal pathways under toxic metal ion stress will be reviewed in the yeast S. cerevisiae.
In-silico Validation of the Proposed Treatment Strategy of Periodontitis
Authors: Mirza Mohd. Aamir , Iqbal Zeenat , Jain Pooja , Farooq Uzma , Nainwal Lalit Mohan , Alam Mumtaz , Poonkuzhi Naseef Punnoth , Kuruniyan Mohamed Saheer 
Published: January 2022

Objective:
The present study aims to assess a proposed treatment approach or therapy
for periodontitis by using the in-silico technique. The proposed treatment strategy offers a singular
vehicular system consisting of minocycline (antibiotic), celecoxib (selective COX-II inhibitor),
doxycycline hyclate (matrix metalloproteinase inhibitor), and hydroxyapatite (osteogenic agent).

Material & Method:
Molecular docking studies of drugs were performed using Maestro version
9.4 software Schrödinger, and 3-Dimensional Crystallographic X-ray protein structures of targeted
proteins were downloaded from RCSB protein data bank in .pdb file format. These agents were
docked, and their affinities towards the receptors/protein/enzyme were calculated. Furthermore,
their affinities were compared with the standard drug.

Results:
The study suggests that minocycline and metronidazole possess equal affinity towards the
RGPB and Inlj protein of P.gingivalis. Celecoxib, a well-known inhibitor of the COX-II enzyme,
showed very high affinity. Selective inhibitor of MMP-8 possessed higher affinity than doxycycline,
whereas CMT-3 showed equal affinity as doxycycline for MMP-13. Similarly, hydroxyapatite
and simvastatin also showed a comparatively similar affinity for osteopontin receptor.

Conclusion:
Based upon molecular docking results, it can be concluded that the proposed treatment
strategy would be a suitable approach for periodontitis and all the selected therapeutic agents
have potential similar to the standard drugs, thereby constituting a reliable system for periodontitis.
Identification of the Metabolites of Scutebarbatine A in Rat Plasma, Bile, Urine, and
feces by Using Ultra-high-performance Liquid Chromatography Coupled with Q
Exactive Hybrid Quadrupole-orbitrap High-resolution Mass Spectrometry
Authors: Zhao Lei , Wang Hongjin , Yuan Nannan , Yang Guochun , Gao Jinwei , Sun Lixin 
Published: January 2022

Background:
Scutebarbatine A is a new neo-Clerodane Diterpenoid Alkaloids from Scutellaria barbata,
which has many pharmacological effects, such as anti-tumor, antibacterial, and anti-inflammatory. However, there
are no studies on the metabolism of Scutebarbatine A.

Objective:
The objective of this study is to explore the metabolism of Scutebarbatine A in the body, the bile, plasma,
urine, and feces samples of rats after administration were investigated.

Methods:
The biological samples were investigated using ultra-high-performance liquid chromatography coupled
with Q Exactive hybrid quadrupole-orbitrap high-resolution mass spectrometry (UPLC-Q-Orbitrap-HRMS).

Results:
A total of 20 metabolites were identified: 16 phase I metabolites and 4 phase II metabolites. The main metabolic
pathways were hydrolysis, oxidation, hydrogenation, dehydration, and combination with sulfate.

Conclusion:
This study further elucidates the metabolism of Scutebarbatine A in rats and provides a reference for the
study of its pharmacodynamic material basis and pharmacological mechanism.
Aminoimidazo[1,2-a]pyridine Bearing Different Pyrazole Moieties as the
Structural Scaffold for the Development of BACE1 Inhibitor; Synthesis,
Structural Characterization, in vitro and in silico Studies
Authors: Mahdavi Mohammad , Ebrahimi Seyed Esmaeil Sadat , Iraji Aida , Jelveh Kourosh , Moazzam Ali , Bahadorikhalili Saeed , Yahya‐Meymandi Azadeh , Larijani Bagher , Biglar Mahmmod , Edraki Najmeh 
Published: January 2022

Abstract:
Regarding the critical role of amyloid-β plaques in the pathogenesis of Alzheimer's disease, a series of aminoimidazo[1,2-a]pyridine derivatives were designed and synthesized as potential anti-BACE1 agents targeting the production of amyloid-β plaques. In vitro biological results demonstrated that compounds 7b and 7f exhibited the best inhibitory potency against BACE1 with IC50 values of 22.48 ± 2.06 and 30.61 ± 3.48 μM, respectively. Also, the ligand-protein docking evaluations revealed that compounds 7b and 7f could effectively bind with the different pockets of BACE1 through different interactions with the residue of the active site. The results of current studies underline the potential role of aminoimidazo[1,2-a] pyridine-containing pyrazole derivatives for developing novel BACE1 inhibitors.
Chemistry of Biologically Active Benzimidazole Scaffolds: Medicinal
Chemistry Perspective
Authors: Bendi Anjaneyulu , Sangeeta  , Singh Lakhwinder , Rao G.B. Dharma 
Published: January 2022

Abstract:
Nowadays, heterocyclic compounds have attained a prominent place among the various
classes of aromatic organic compounds. Benzimidazoles are important classes of heterocyclic compounds
that comprise six-member benzene and five-member imidazole fused ring systems. Benzimidazole
scaffolds remain the central focus among the available heterocyclic compounds because of several
pharmacological, clinical, and biological properties. Benzimidazoles attain the focus due to their
stability, outstanding bioavailability, and wide spectrum of biological efficiency. The present study
reveals and discusses the chemistry of various benzimidazole scaffolds widely used in medicinal
chemistry with the available data until 2021.
A Novel Electrochemical Genosensor for Specific Detection of xanQ Gene
in Escherichia coli Strains in Water
Authors: Deshmukh Rehan , Roy Utpal , Bhand Sunil 
Published: January 2022

Background:
A rapid and specific detection of pathogens is of great importance from
public health viewpoint as well as from economic perspectives. Genosensor based on sequence
specific detection of Escherichia coli facilitates significant improvements in rapidity and specificity
over traditional microbiological methods.

Objective:
The present study was aimed at identifying a sequence of xanQ genetic markers for
designing the DNA sensing probe and fabricating a genosensor using the interdigitated gold electrode
(IDE). A label-free genosensor for E. coli detection in water by a novel nucleic acid sensing
probe, URecA1016 is reported. The URecA1016 sensing probe-functionalized gold-interdigitated
electrode surface by covalent coupling using 11-Mercaptoundecanoic acid (crosslinker) to develop
the electrochemical genosensor.

Results:
Upon DNA hybridization, the non-Faradaic sensing measurements showed a decreasing
capacitance value with 10 min response time at 120 Hz frequency and 10 mV applied potential.
The linearity range of the genosensor was between 1 and 1000 pg/mL for DNA of E. coli with a
limit of quantification (LoQ) of 1.27 pg DNA/mL of E. coli (equivalent to approximately 150
CFU/mL) at 95 % confidence. Whilst the genosensor was E. coli species-specific as has been tested
for the detection of E. coli MTCC 3221, E. coli O157:H7 ATCC 43895, E. coli O78:H11 MTCC
723 any cross-reactivity could not be observed with DNA of Shigella flexneri MTCC 9543 and
Bacillus subtilis MTCC 736. The capacitance change responses were also recorded and discussed.

Conclusions:
The URecA1016 sensing probe was found to be specific for the detection of different
E. coli species spiked in water. The results obtained in our study demonstrated the possible application
potential of genosensor for E. coli detection in real water samples.
Therapeutic Effects and Mechanism of Liraglutide in Rats with Type 2
Diabetes and Metabolic-associated Fatty Liver Disease
Authors: Zhao Xuanye , Liu Yaoji , Liu Jingjin , Qin jie 
Published: January 2022

•	Background:
SREBP-1c/Insig/SCAP acts as a lipid de novo synthesis pathway, and its factors are highly expressed in the endoplasmic reticulum[4]. At present, this pathway has become a research hotspot in the development of metabolic-associated fatty liver disease. However, there are few studies on how various factors in this pathway change after endoplasmic reticulum stress; in particular, the role of the insulin-inducing gene-1 (Insig-1) has not been elucidated in detail.

•	Objective:
To investigate whether liraglutide has a therapeutic effect on rats with T2DM and MAFLD and to further study its possible mechanism

•	Method:
rats in the control group and modeling group were fed with normal diet and high-sugar and high-fat diet, respectively . After one month, the mice in the modeling group were injected with 35mg/kg STZ intraperitoneally to establish the model of type 2 diabetes mellitus. T2DM and MAFLD rats were randomly divided into three groups: model group, low dose liraglutide group, and high dose liraglutide group. Fasting blood glucose ,fasting insulin, blood lipid profile, alanine aminotransferase, and aspartate aminotransferase were measured at the end of the 8th week. Paraffin sections were obtained from the same part of the liver of rats in each group and observed by electron microscope after HE staining. Western blot was used to detect the expression of endoplasmic reticulum stress index (GRP78) and negative feedback index of lipid synthesis (Insig-1) in each group.

•	Results:
Liver tissue from the drug intervention groups caused a decrease in lipid droplet vacuoles, and the hepatocytes were arranged neatly again. While the expression of GRP78 rose, Insig-1 declined. There were differences with different doses of liraglutide; the higher the dose was, the more obvious the effect. No such changes were observed in T2DM and MAFLD rats after injection of saline.

•	Conclusion:
we show that liraglutide may have a therapeutic effect on rats with T2DM and MAFLD by reducing endoplasmic reticulum stress in the liver and increasing the expression of Insig-1.
System-Level Factors Associated With Telephone and Video Visit Use: Survey of Safety-Net Clinicians During the Early Phase of the COVID-19 Pandemic
Authors: Sharma Anjana E , Khoong Elaine C , Sierra Maribel , Rivadeneira Natalie A , Nijagal Malini A , Su George , Lyles Courtney R , DeFries Triveni , Tuot Delphine S , Sarkar Urmimala 
Published: January 2022

Background
The COVID-19 pandemic prompted safety-net health care systems to rapidly implement telemedicine services with little prior experience, causing disparities in access to virtual visits. While much attention has been given to patient barriers, less is known regarding system-level factors influencing telephone versus video-visit adoption. As telemedicine remains a preferred service for patients and providers, and reimbursement parity will not continue for audio visits, health systems must evaluate how to support higher-quality video visit access.

Objective
This study aimed to assess health system–level factors and their impact on telephone and video visit adoption to inform sustainability of telemedicine for ambulatory safety-net sites.

Methods
We conducted a cross-sectional survey among ambulatory care clinicians at a hospital-linked ambulatory clinic network serving a diverse, publicly insured patient population between May 28 and July 14, 2020. We conducted bivariate analyses assessing health care system–level factors associated with (1) high telephone adoption (4 or more visits on average per session); and (2) video visit adoption (at least 1 video visit on average per session).

Results
We collected 311 responses from 643 eligible clinicians, yielding a response rate of 48.4%. Clinician respondents (N=311) included 34.7% (n=108) primary or urgent care, 35.1% (n=109) medical, and 7.4% (n=23) surgical specialties. Our sample included 178 (57.2%) high telephone adopters and 81 (26.05%) video adopters. Among high telephone adopters, 72.2% utilized personal devices for telemedicine (vs 59.0% of low telephone adopters, P=.04). Video nonadopters requested more training in technical aspects than adopters (49.6% vs 27.2%, P<.001). Primary or urgent care had the highest proportion of high telephone adoption (84.3%, compared to 50.4% of medical and 37.5% of surgical specialties, P<.001). Medical specialties had the highest proportion of video adoption (39.1%, compared to 14.8% of primary care and 12.5% of surgical specialties, P<.001).

Conclusions
Personal device access and department specialty were major factors associated with high telephone and video visit adoption among safety-net clinicians. Desire for training was associated with lower video visit use. Secure device access, clinician technical trainings, and department-wide assessments are priorities for safety-net systems implementing telemedicine.