bluuebunny/crossref_metadata_2025_split huggingface dataset:
A-307 Relationship Between Nonverbal Measure of Intelligence and Achievement Performance in Rural, Latinx Youth
Authors: McMillen Taylor , Young Krysta , Carlson Katherine , Hamilton Elizabeth 
Published: August 2022

Abstract
Objective: This study examines the relationship between the Wechsler Nonverbal Scale of Ability (WNV) and achievement in rural Latinx youth. Although concurrent validity for the WNV with other intelligence measures is established, there is sparse research on its association with academic performance.
Methods: Participants (n=15) were Latinx youth, ages 8 to 17 years, including nine males and six females. Participants were administered the WNV and the Woodcock-Johnson IV Tests of Achievement (WJ-IV-ACH) as part of a psychoeducational battery. The WNV minimizes cultural/linguistic factors, providing a Full Scale score and four subtests: 1) Matrices, 2) Coding, 3) Spatial Span, and 4) Picture Arrangement. The WJ-IV-ACH includes Broad Achievement and academic cluster scores. Correlations analyzed relationships between WNV and WJ-IV-ACH scores.
Results: A moderate correlation was found between WNV Full Scale and Broad Achievement (r= .44). Matrices and Picture Arrangement were moderately related to Broad Achievement (r= .39, r= .39). Matrices was strongly correlated to reading fluency (r= .60), and moderately correlated to broad reading (r= .39) and math problem solving (r= .34). Coding was associated with math calculation (r= .48). Spatial Span was strongly correlated with math problem solving (r=.53) and linked to math calculation (r= .48). Picture Arrangement was moderately correlated with broad reading, reading comprehension, math problem solving, and written expression (r= .37, r= .31, r= .33, r= .30).
Conclusion: Despite the small sample size, results suggest that a diversity-informed measure of intellectual ability is related to youth’s broad achievement scores. Additionally, WNV subtest scores are differentially associated with academic domains.
A-309 Detecting Coached Malingerers: Validity of the Novel Tri-Choice Naming and Response Bias Measure
Authors: Huston Chloe , Poreh Amir 
Published: August 2022

Abstract
Objective: The prevalence of malingering following a personal injury is estimated to be more than 50% (Resnick, 1997). Thus, it is imperative to have malingering measures that are well-validated (Janaski et al., 2011). Ideally, malingering tests should have high sensitivity and specificity (Trevethan, 2017). The Tri-Choice Naming and Response Bias Measure (N-Tri) is a novel malingering test aimed at being less susceptible to coaching than existing tests. This study aimed to validate the N-Tri for detection of coached malingerers.
Methods: 282 neurotypical participants completed an online version of the N-Tri. The N-Tri consists of three blocks: a naming block, a study and forced-choice block, and a delayed forced-choice block. Participants were randomly assigned to either the coached simulators’ group or the control group. The coached group was instructed to perform as if they have a traumatic brain injury (TBI) and received a test-taking strategy.
Results: ROC curves were used to determine optimal cutoff values, which were chosen based off Youden’s index (Youden, 1950). Block 1 had a sensitivity of 92% and a specificity of 99%. Block 2 had a sensitivity of 95% and a specificity of 98%. Block 3 had a sensitivity of 96% and a specificity of 97%. Total score had a sensitivity of 97% and a specificity of 97%.
Conclusions: This study demonstrated that all blocks and total score of a novel malingering test, the N-Tri, were able to distinguish between coached malingerers and controls with high levels of sensitivity and specificity. Further research that utilizes patients with documented memory deficits are proposed.
A-311 WMS-IV Visual Reproduction Recognition as a Performance Validity Test (PVT) in Clinical and Forensic Settings
Authors: Smotherman Jesse , Cecil Audrey L , Glayat Kathryn , Arredondo Beth , Brickell Emily , Boettcher Anneliese 
Published: August 2022

Abstract
Objective: This study examined WMS-IV Visual Reproduction Recognition (VRRec) as an embedded PVT in clinical and forensic samples.
Methods: VRRec was analyzed as a PVT in a forensic sample and in a hospital-based, outpatient clinical sample. Neither sample included any major neurocognitive disorders and well-established PVTs determined valid and invalid categories. T-tests (parametric and nonparametric) and ROCs were used to assess how accurately VRRec classified valid and invalid group-membership.
Results: Forensic and clinical (n=265, 84) samples differed in context (incentivized, non-incentivized), age (m=49.1, 60.6), race (Caucasian=17%, 89%), and gender (males=100%, 29%), respectively. VRRec scores were significantly different between valid and invalid groups in both the forensic sample (U=2404.0, p&lt;.0001, d=-1.26; n=196, 69; m=5.57, 3.33; sd=1.29, 1.91) and the clinical sample (t=-2.39, p=.019, d=-.93; n=76, 8; m=4.99, 3.50; sd=1.68, 1.51). A cutoff score of &lt; 3 yielded the following: Forensic: AUC=.822, sensitivity=.551, specificity=.944, 95%CI=.76-.88, p&lt;.0001; and Clinical: AUC=.752, sensitivity=.500, specificity=.816, 95%CI=.61-.89, p=.019. For the clinical sample, &lt; 2 improved specificity (.908) but decreased sensitivity (.250). When using a 15% estimated invalidity base rate in the clinical sample for &lt; 3 and &lt; 2 cutoffs, positive predictive power equaled .324 and .324 and negative predictive power equaled .902 and .873, respectively.
Conclusion: VRRec adequately differentiated validity groups in a forensic sample but was less valuable in a clinical sample. Its use as a PVT should only be considered within a larger group of multiple PVTs. Primary limitations included differences in demographics and specific criterion-PVTs used between samples. Future studies should assess VRRec as a PVT in similar populations.
Restoration Liposuction of the Abdomen: High-Definition Liposuction With Umbilicus and Lower Abdomen Improvement Using Polydioxanone Threads
Authors: Yu Arthur Y 
Published: August 2022

Abstract

Background
Abdominal high-definition liposuction has been practiced for many years. However, problems such as low-lying, “sad-looking” umbilici and lower abdominal “pooches” remain unresolved. Additionally, the waistline, as the pivotal point connecting the chest and hips, deserves more attention and improvement.

Objectives
The aim of this study was to use polydioxanone (PDO) threads after liposuction: (1) to improve the shape and position of the umbilicus permanently; (2) to tighten the lower abdomen permanently; and (3) to redefine “high-definition” liposuction.

Methods
All patients underwent high-definition liposuction of the abdomen and waist. After liposuction, bidirectional, barbed PDO threads were placed in the upper central abdomen. The threads were pulled to cinch the upper abdominal skin and then tied. The resulting umbilicus elevation was measured for up to 12 months. Higher waistlines were also created to match higher-positioned umbilici.

Results
Fifty-two female subjects were included. The range of umbilicus elevation at 12 months was 0.8 to 3.6 cm. Most umbilici were converted to vertical orientation, and lower abdomens became lengthened, flattened, and tightened. Moreover, the enhanced waistlines and body curves created better body proportions.

Conclusions
This technique results in permanent elevation and shape enhancement of both umbilicus and lower abdomen. In addition, because the umbilicus is raised, a higher waistline can be created without any discordance, making the lower limbs appear longer. Overall, the maneuvers contributed to the restoration/rejuvenation of the abdomen and created a better overall body shape and proportion.

Level of Evidence: 4
12-O-Tetradecanoylphorbol 13-acetate promotes proliferation and epithelial–mesenchymal transition in HHUA cells cultured on collagen type I gel: A feasible model to find new therapies for endometrial diseases
Authors: Hanaki Yusuke , Miyoshi Sena , Sugiyama Yasunori , Yanagita Ryo C , Sato Masashi 
Published: August 2022

ABSTRACT
HHUA endometrial adenocarcinoma cells aggregated into spheroids when cultured on collagen type I gels. 12-O-Tetradecanoylphorbol 13-acetate, a PKC activator, disassembled the spheroids through epithelial–mesenchymal transition and increased their proliferation rate, while inducing cell death under monolayer culture conditions. These unusual behaviors of endometrial epithelial cells with collagen fibers could be a target for the treatment of some endometrial diseases.
Metabolites with antioxidant andα-glucosidase inhibitory activities produced by the endophytic fungiAspergillus nigerfromPachysandra terminalis
Authors: Yang Tao , Yang Kailing , Zhang Yu , Zhou Ruixi , Zhang Fuxin , Zhan Guanqun , Guo Zengjun 
Published: August 2022

ABSTRACTOne new compound and 13 known compounds were isolated from Aspergillus niger, a plant endophytic fungus of Pachysandra terminalis collected from Qinling Mountains, Xi'an, China. The structure of new compound 1 was classically determined by extensive spectroscopic analysis. Compounds 5, 6, 8, and 14 were first reported from Aspergillus, while compound 2 was isolated from A. niger for the first time. All isolated compounds were further evaluated for their antioxidant and α-glucosidase inhibitory activities. Compounds 2 and 3 exhibited significant antioxidant activities with IC50 values of 31.64 μm and 24.32 μm, respectively, similar to the positive control ascorbic acid. Additionally, compound 1 displayed remarkable inhibitory activity against α-glucosidase with an IC50 value of 96.25 μm, which was 3.4-fold more potent than that of the positive control acarbose. Compound 1 has great potential for development as a new lead compound owing to its simple structure and remarkable biological activity.
2-Oxo-imidazole dipeptides in meat
Authors: Komae Somei , Kasamatsu Shingo , Ihara Hideshi 
Published: August 2022

ABSTRACT
2-Oxo-imidazole dipeptides (2-oxo-IDPs) are highly functional, but it is unclear whether 2-oxo-IDPs exist in meat. Here, we measured 2-oxo-IDPs levels in meat and observed that they varied according to animal species and body parts. In addition, 2-oxo-IDPs in chicken breast extract increased after aeration in the presence of CuSO4/ascorbate, suggesting the potential of elevated 2-oxo-IDPs in effective usage of meat.
Fenretinide combines perturbation of signaling kinases, cell–extracellular matrix interactions and matrix metalloproteinase activation to inhibit invasion in oral squamous cell carcinoma cells
Authors: Wang Daren , Pei Ping , Shea Fortune F , Bissonnette Caroline , Nieto Kari , Din Corrine , Liu Yayuan , Schwendeman Steven P , Lin Yan X , Spinney Richard , Mallery Susan R 
Published: August 2022

AbstractBasement membrane invasion defines malignant transformation of surface premalignancy. Treatment of oral squamous cell carcinoma (OSCC) cells with the synthetic vitamin A derivative, fenretinide (4HPR), induces numerous cancer-preventive effects including suppression of basement membrane invasion, elimination of anchorage-independent growth, disruption of actin cytoskeletal components and inhibition of the invasion-enabling focal adhesive kinase. The purpose of this study was to elucidate 4HPR’s effects on additional invasion-relevant mechanisms including matrix metalloproteinase (MMP) activation and function, cell–extracellular matrix (ECM) attachments and interaction with a kinase that is essential for the epithelial–myoepithelial transformation i.e. c-Jun NH2-terminal kinase (JNK). Our data revealed that 4HPR binds with high affinity to the ATP-binding site of all three JNK isoforms with concurrent suppression of kinase function. Additional studies showed 4HPR treatment inhibited both OSCC cell–ECM adhesion and MMP activation and function. JNK downregulation and induced expression studies confirmed that the JNK3 isoform conveyed that largest impact on OSCC migration and invasion. Biodegradable polymeric implants formulated to preserve 4HPR’s function and bioavailability were employed to assess 4HPR’s chemopreventive impact on an OSCC tumor induction model. These studies revealed 4HPR local delivery significantly inhibited OSCC tumor size, mitotic indices and expression of the endothelial marker, erythroblast transformation-specific-related gene with concurrent increases in tumor apoptosis (cleaved caspase-3). Collectively, these data show that 4HPR suppresses invasion at multiple sites including ‘outside-in’ signaling, cell–ECM interactions and suppression of MMPs. These functions are also essential for physiologic function. Regulation is therefore essential and reinforces the pharmacologic advantage of local delivery chemopreventive formulations. .
Global media ethics, the good life, and justice
Authors: Hove Thomas 
Published: August 2022

AbstractOne of the challenges for global media ethics is to define a theoretical perspective from which to adjudicate cross-cultural value conflicts. Early work in this field attempted to identify a universal norm from which the specific, applied norms of media professions and practices could be derived. However, postcolonial and pluralist critiques have revealed potential problems with this approach. To avoid such problems, neo-Aristotelian critiques have proposed focusing less on defining universal norms of obligated action and more on acknowledging local variations in conceptions of the good life. These critiques rightly stress the goal of understanding the diversity of ethical values both within and across cultures. However, when the goal of media ethics is to provide guidance for cooperative resolutions of value conflicts, the generalizability of norms remains an important issue. This article reframes this debate more as a division of labor than as a rivalry in approaches.
SC2sepsis: sepsis single-cell whole gene expression database
Authors: Li Yinjiaozhi , Tan Ruoming , Chen Yang , Liu Zhaojun , Chen Erzhen , Pan Tingting , Qu Hongping 
Published: August 2022

Abstract

Sepsis, one of the major challenges in the intensive care unit, is characterized by complex host immune status. Improved understandings of the phenotypic changes of immune cells during sepsis and the driving molecular mechanisms are critical to the elucidation of sepsis pathogenesis. Single-cell RNA sequencing (scRNA-seq), which interprets transcriptome at a single-cell resolution, serves as a useful tool to uncover disease-related gene expression signatures of different cell populations in various diseases. It has also been applied to studies on sepsis immunopathological mechanisms. Due to the fact that most sepsis-related studies utilizing scRNA-seq have very small sample sizes and there is a lack of an scRNA-seq database for sepsis, we developed Sepsis Single-cell Whole Gene Expression Database Website (SC2sepsis) (http://www.rjh-sc2sepsis.com/), integrating scRNA-seq datasets of human peripheral blood mononuclear cells from 45 septic patients and 26 healthy controls, with a total amount of 232 226 cells. SC2sepsis is a comprehensive resource database with two major features: (i) retrieval of 1988 differentially expressed genes between pathological and healthy conditions and (ii) automatic cell-type annotation, which is expected to facilitate researchers to gain more insights into the immune dysregulation of sepsis.

Database URL
http://www.rjh-sc2sepsis.com/
Cardiac mechanics in response to proteasome inhibition: a prospective study
Authors: Makris Nikolaos , Georgiopoulos Georgios , Laina Aggeliki , Tselegkidi Maria-Eirini , Fotiou Despoina , Kanellias Nikolaos , Eleftherakis-Papaiakovou Evaggelos , Migkou Magda , Papanagnou Eleni-Dimitra , Katogiannis Konstantinos , Petropoulos Ioannis , Anninos Hector , Bampatsias Dimitrios , Maneta Eleni , Samouilidou Elisabeth , Nikas Dimitris , Ciliberti Giorgia , Stellos Konstantinos , Terpos Evaggelos , Gavriatopoulou Maria , Trougakos Ioannis P , Ikonomidis Ignatios , Dimopoulos Meletios-Athanasios , Kastritis Efstathios , Stamatelopoulos Kimon 
Published: August 2022

Abstract

Aim
Ubiquitin-Proteasome System (UPS) is of paramount importance regarding the function of the myocardial cell. Consistently, inhibition of this system has been found to affect myocardium in experimental models; yet, the clinical impact of UPS inhibition on cardiac function has not been comprehensively examined. Our aim was to gain insight into the effect of proteasome inhibition on myocardial mechanics in humans.

Methods and results
We prospectively evaluated 48 patients with multiple myeloma and an indication to receive carfilzomib, an irreversible proteasome inhibitor. All patients were initially evaluated and underwent echocardiography with speckle tracking analysis. Carfilzomib was administered according to Kd treatment protocol. Follow-up echocardiography was performed at the 3rd and 6th month. Proteasome activity (PrA) was measured in peripheral blood mononuclear cells.
At 3 months after treatment, we observed early left ventricular (LV) segmental dysfunction and deterioration of left atrial (LA) remodelling, which was sustained and more pronounced than that observed in a cardiotoxicity control group. At 6 months, LV and right ventricular functions were additionally attenuated (P &lt; 0.05 for all). These changes were independent of blood pressure, endothelial function, inflammation, and cardiac injury levels. Changes in PrA were associated with changes in global longitudinal strain (GLS), segmental LV strain, and LA markers (P &lt; 0.05 for all). Finally, baseline GLS &lt; −18% or LA strain rate &gt; 1.71 were associated with null hypertension events.

Conclusion
Inhibition of the UPS induced global deterioration of cardiac function.
Current and future use of neuromodulation in heart failure
Authors: Duncker David , Bauersachs Johann 
Published: August 2022

Abstract
Autonomic imbalance is a common finding in heart failure (HF) with reduced ejection fraction (HFrEF). Addressing different targets within the autonomic nervous systems has been evaluated in patients with HF, including renal sympathetic denervation, vagal nerve stimulation, and baroreceptor activation therapy (BAT). Although all are pathophysiologically plausible and promising, only BAT shows sufficient evidence for implementation into clinical practice in randomized controlled trials. Baroreceptor activation therapy can be used in patients with symptomatic HFrEF despite optimal guideline-directed medication and device therapy. This article reviews the current and future use of neuromodulation in HF and provides an overview on current guideline recommendations and clinical practice.
ZW sex-chromosome evolution and contagious parthenogenesis in Artemia brine shrimp
Authors: Elkrewi Marwan , Khauratovich Uladzislava , Toups Melissa A , Bett Vincent Kiplangat , Mrnjavac Andrea , Macon Ariana , Fraisse Christelle , Sax Luca , Huylmans Ann Kathrin , Hontoria Francisco , Vicoso Beatriz 
Published: August 2022

Abstract
Eurasian brine shrimp (genus Artemia) have closely related sexual and asexual lineages of parthenogenetic females, which produce rare males at low frequencies. Although they are known to have ZW chromosomes, these are not well characterized, and it is unclear whether they are shared across the clade. Furthermore, the underlying genetic architecture of the transmission of asexuality, which can occur when rare males mate with closely related sexual females, is not well understood. We produced a chromosome-level assembly for the sexual Eurasian species Artemia sinica and characterized in detail the pair of sex chromosomes of this species. We combined this new assembly with short-read genomic data for the sexual species Artemia sp. Kazakhstan and several asexual lineages of Artemia parthenogenetica, allowing us to perform an in-depth characterization of sex-chromosome evolution across the genus. We identified a small differentiated region of the ZW pair that is shared by all sexual and asexual lineages, supporting the shared ancestry of the sex chromosomes. We also inferred that recombination suppression has spread to larger sections of the chromosome independently in the American and Eurasian lineages. Finally, we took advantage of a rare male, which we backcrossed to sexual females, to explore the genetic basis of asexuality. Our results suggest that parthenogenesis is likely partly controlled by a locus on the Z chromosome, highlighting the interplay between sex determination and asexuality.
Suppressor mutations that make the essential transcription factor Spn1/Iws1 dispensable inSaccharomyces cerevisiae
Authors: López-Rivera Francheska , Chuang James , Spatt Dan , Gopalakrishnan Rajaraman , Winston Fred 
Published: August 2022

AbstractSpn1/Iws1 is an essential eukaryotic transcription elongation factor that is conserved from yeast to humans as an integral member of the RNA polymerase II elongation complex. Several studies have shown that Spn1 functions as a histone chaperone to control transcription, RNA splicing, genome stability, and histone modifications. However, the precise role of Spn1 is not understood, and there is little understanding of why it is essential for viability. To address these issues, we have isolated 8 suppressor mutations that bypass the essential requirement for Spn1 in Saccharomyces cerevisiae. Unexpectedly, the suppressors identify several functionally distinct complexes and activities, including the histone chaperone FACT, the histone methyltransferase Set2, the Rpd3S histone deacetylase complex, the histone acetyltransferase Rtt109, the nucleosome remodeler Chd1, and a member of the SAGA coactivator complex, Sgf73. The identification of these distinct groups suggests that there are multiple ways in which Spn1 bypass can occur, including changes in histone acetylation and alterations in other histone chaperones. Thus, Spn1 may function to overcome repressive chromatin by multiple mechanisms during transcription. Our results suggest that bypassing a subset of these functions allows viability in the absence of Spn1.