bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of chemoradiation on the immune microenvironment of cervical cancer patients
Authors: Herter J. M. , Kiljan M. , Kunze S. , Reinscheid M. , Ibruli O. , Cai J. , Niu L. , Heßelmann I. , Trommer M. , Herter-Sprie G. S. , Köhler C. , Marnitz S. 
Published: October 2022

Abstract
Purpose
Cervical cancer remains a leading cause of cancer death in women. While immunotherapy has shown great success in combating cancer, the value of immunotherapy in cervical cancer is still only beginning to be explored. Thus, we performed a prospective analysis of patient blood and tumor samples at the beginning and end of conventional chemoradiation to assess changes in the immune cell and immunoreceptor compartments, and investigate if and when the addition of immunotherapy could be beneficial.

Methods
Patients with FIGO II–III cervical cancer receiving standard chemoradiation between January 2020 and December 2021 were included. We collected tumor and blood samples from patients before and at the end of therapy and analyzed immune cell composition and immune checkpoint receptor expression on both immune and tumor cells using multicolor flow cytometry.

Results
In all, 34 patients were eligible in the study period; 22 could be included and analyzed in this study. We found that chemoradiation significantly reduces T cell numbers in both tumors and blood, but increases macrophage and neutrophil numbers in tumors. Furthermore, we found that the percentage of immune checkpoint receptor PD‑1 and TIGIT-expressing cells in tumors was significantly reduced at the end of therapy and that CD4 and CD8 memory T cell populations were altered by chemoradiation. In addition, we observed that while PD-L1 expression intensity was upregulated by chemoradiation on blood CD8 cells, PD-L1 expression frequency and the expression intensity of antigen-presenting molecule MHC‑I were significantly reduced on tumor cells.

Conclusion
Our data demonstrate that chemoradiation significantly alters the immune cell composition of human cervical tumors and the expression of immune checkpoint receptors on both lymphocytes and tumor cells. As our results reveal that the percentage of PD‑1+ CD8 cells in the tumor as well as the frequency of PD-L1-expressing tumor cells were reduced at the end of therapy, neoadjuvant or simultaneous anti-PD‑1 or anti-PD-L1 treatment might provide better treatment efficiency in upcoming clinical studies.
Nonpapillary prone endoscopic combined intrarenal surgery: effectiveness, safety and tips, and tricks
Authors: Kallidonis Panagiotis , Tsaturyan Arman , Faria-Costa Gabriel , Ballesta Martinez Begona , Peteinaris Angelis , Adamou Constantinos , Pagonis Konstantinos , Natsos Anastasios , Vrettos Theofanis , Liatsikos Evangelos 
Published: October 2022

Abstract
Purpose
To evaluate the effectiveness and safety of nonpapillary prone endoscopic combined intrarenal surgery (ECIRS) and provide practical tips and tricks for the successful accomplishment of the procedure respecting the anatomical particularities.

Material and methods
This study is an analysis of a prospectively collected database including all cases of ECIRS performed between January 2019 and December 2021 in a high-volume tertiary center. All patients underwent the procedure in prone-split leg position. A nonpapillary renal puncture was performed. The used access sheaths were 22Fr or 30Fr. Lithotripsy was performed anterogradely with a dual-energy lithotripter with incorporated suction and retrogradely with holmium Yttrium–Aluminum–Garnet laser.

Results
A total of 33 patients were included. The initial stone-free rate (SFR) was 84.8% and the final SFR was 90.9%. The median stone size was 35 mm and 60% of patients had staghorn calculi. The prevalence of renal abnormalities was 21.3%, including 3 cases of horseshoe kidney, 2 cases of malrotation and 2 cases with complete duplicated systems. The median operative time was 47 min. The median hospital stay was 3 days and median hemoglobin loss was 1.2 gr/dL. Overall, the complication rate was 9.1%, all being Grade II complications (n = 2 fever and n = 1 transient bleeding).

Conclusions
Nonpapillary prone ECIRS is an effective and safe procedure. Standardization of the procedure is critical to achieve good outcomes. Patients who benefit the most are probably the ones where additional punctures can be avoided using this technique, namely patients with renal abnormalities, incrusted ureteral stents and staghorn stones.
White matter microstructure and verbal fluency
Authors: Egorova-Brumley Natalia , Liang Chen , Khlif Mohamed Salah , Brodtmann Amy 
Published: October 2022

AbstractPoor performance on verbal fluency tasks is associated with an increased risk of post-stroke cognitive impairment. Grey matter regions supporting verbal fluency have been identified via lesion–symptom mapping, but the links between verbal fluency and white matter structure remain less well described. We examined white matter correlates of semantic (Category Fluency Animals) and phonemic or lexical fluency (COWAT FAS) after stroke, accounting for stroke severity measured with the National Institutes of health Stroke Scale (NIHSS), age, sex, and level of education. White matter fibre density and cross-section measures were automatically extracted from 72 tracts, using MRtrix and TractSeg software in 72 ischaemic stroke survivors assessed 3 months after their event. We conducted regression analyses separately for phonemic and semantic fluency for each tract. Worse semantic fluency was associated with lower fibre density in several tracts, including the arcuate fasciculus, superior longitudinal fasciculus, inferior occipito-frontal fasciculus, inferior longitudinal fasciculus, optic radiation, striato-occipital, thalamo-occipital tracts, and inferior cerebellar peduncle. Our stroke sample was heterogenous with largely non-overlapping and predominantly right-lateralised lesions (lesion distribution: left N = 27, right N = 43, bilateral N = 2), dissimilar to previous studies of verbal fluency. Yet, the tracts we identified as correlates of semantic fluency were all left-lateralised. No associations between phonemic fluency performance and fibre density metrics in any of the white matter tracts we extracted survived correction for multiple comparisons, possibly due to the limitations in the selection of tracts and sample characteristics. We conclude that when accounting for the effects of stroke severity, sex, age, and education, semantic fluency is associated with white matter microstructure in the left arcuate fasciculus, superior longitudinal fasciculus, and several occipital tracts, possibly reflecting the disconnection in the sagittal stratum. Our results obtained with fixel-based analysis, complement previous findings obtained with lesions–symptom mapping and neurodegenerative approaches.
Risk of cancer in individuals with Lynch-like syndrome and their families: a systematic review
Authors: Nugroho Pandu P. , Ghozali Siti Alyaa S. , Buchanan Daniel D. , Pisano Mia I. , Reece Jeanette C. 
Published: October 2022

Abstract
Background
Lynch-like syndrome (LLS) tumors have similar clinicopathological features to Lynch syndrome (LS) tumors but have no identifiable pathogenic germline mismatch repair gene variant. However, cancer risks in LLS patients and first-degree relatives (FDRs) are not well defined.

Methods
To clarify LLS-associated cancer risks, a systematic review of all studies examining all cancer risks in LLS was performed. Searching of Medline, Embase, Pubmed, Cochrane and CINAHL databases and reference/citation checking identified relevant studies published between January 1, 1980 and February 11, 2021. Joanna Briggs Institute Appraisal Tools assessed the risk of bias.

Results
Six studies (five cohort/one cross-sectional) were eligible for study inclusion. One study found no difference in colorectal cancer (CRC) incidence between LLS and LS patients or CRC risks at aged 70 years. Three studies found CRC incidence in LLS FDRs was higher than the general population but lower than LS FDRs. Two studies showed no difference in CRC diagnosis age between LLS patients and LS patients. Endometrial cancer risks in LLS patients were higher than the general population but lower than LS patients.

Conclusion
Evidence of elevated CRC risks in LLS patients and FDRs supports increased colonoscopy surveillance strategies for LLS patients and FDRs in line with current recommendations for LS. Due to heterogeneity amongst LLS populations, extended intervals between screening may be advised for low-risk families. Studies to resolve the molecular characterization and definition of LLS are needed to clarify cancer risks associated with LLS which in turn may individualize surveillance strategies for LLS patients and families.
Reduced mortality for over-the-scope clips (OTSC) versus surgery for refractory peptic ulcer bleeding: a retrospective study
Authors: Kuellmer Armin , Mangold Tobias , Bettinger Dominik , Schiemer Moritz , Mueller Julius , Wannhoff Andreas , Caca Karel , Wedi Edris , Kleemann Tobias , Thimme Robert , Schmidt Arthur 
Published: October 2022

Abstract
Background
Surgery or transcatheter arterial embolization or are both considered as standard treatment of peptic ulcer bleeding (PUB) refractory to endoscopic hemostasis. Over-The-Scope clips (OTSC) have shown superiority to standard endoscopic treatment but a comparison with surgery has not been performed, yet.

Patients and methods
In this retrospective, multicenter study, 103 patients treated with OTSC (n = 66) or surgery (n = 37) for refractory PUB in four tertiary care centers between 2009 and 2019 were analyzed. Primary endpoint was clinical success (successful hemostasis and no rebleeding within seven days). Secondary endpoints were adverse events, length of ICU-stay and in-hospital mortality. Univariable and multivariable regression models were performed to define predictive factors for allocation to surgical therapy and for mortality.

Results
Age, comorbidities, anticoagulation therapy, number of pretreatments, ulcer location, and Rockall-Score were similar in both groups. In the surgical group, there were significantly more patients in shock at rebleeding (78.1% vs. 43.9%; p = 0.002), larger ulcers (18.6 ± 7.4 mm vs. 23.0 ± 9.4 mm; p = 0.017) and more FIa bleedings (64.9% vs. 19.7%; p < 0.001) were detected. Clinical success was comparable (74.2% vs. 83.8%; p = 0.329). In the surgical group, length of ICU-stay (16.2 ± 18.0 days vs. 4.7 ± 6.6 days; p < 0.001), severe adverse events (70.3% vs. 4.5%; p < 0.001) and in-hospital mortality (35.1% vs. 9.1%; p = 0.003) were significantly higher. Multivariable analysis defined shock at rebleeding as the main predictor for allocation to surgical therapy (OR 4.063, 95%CI {1.496–11.033}, p = 0.006). Postsurgical adverse events were the main reason for the in-hospital mortality (OR 5.167, 95% CI {1.311–20.363}, p = 0.019).

Conclusion
In this retrospective study, OTSC compared to surgical treatment showed comparable clinical success but was associated with shorter ICU-stay, less severe adverse events and lower in-hospital mortality.
Phenotypic Characterization of a Wild-Type Population of Cornelian Cherries (Cornus mas L.) from Austria
Authors: Borroto Fernández Eduviges G. , Mokhber Azar , Zeiser Maria , Laimer Margit 
Published: October 2022

AbstractCornelian cherry (Cornus mas L.) belongs to a group of fruit and nut species growing in Europe considered to be underused economically, although it has been recognized as a potential regional “superfood” and as a source of valuable bioactive compounds. Phenotyping fruits of 30 accessions of an Austrian wildtype population of C. mas allowed to evaluate their nutraceutical potential. Ten fruits per accession were characterized by morphological and morphometric approaches. Biochemical analyses were performed to determine the respective amounts of vitamin C, sugars, anthocyanins, iridoids and flavonoids. Both datasets were subjected to statistical analyses. Morphological and morphometric characterization and biochemical analyses enabled the identification of the individuals with the highest economic value. Statistical treatment of data identified the most significant principal components. The first phenotypic profiling of bioactive compounds of wildtype C. mas in Austria yielded a high variability. Dealing with wildtype plants, this is not surprising. However, our results allow to select among the Austrian C. mas accessions the most interesting individuals for further breeding of this alternative fruit with interesting nutritional values.
Yield displacement charts for performance-based seismic design
Authors: Hernández-Montes Enrique , Jalón María L. , Chiachío Juan , Gil-Martín Luisa María 
Published: October 2022

AbstractA new tool for seismic design is presented, called Yield Displacement Charts (YDC). As with its predecessors, the Yield Point Spectra (YPS) and the Yield Frequency Spectra (YFS), the YDC concept takes advantage of the simple features of yield displacement (uy), to use uy in a performance-based design instead of a force-based period-dependent approach. A self-contained and comprehensive approach to YPS and YFS is presented, enabling the novel aspect of YDC to be introduced: a tool for a multi-performance objective design that only depends on the location of the structure to be designed. Once the yield displacement chart has been calculated for a particular place, it can be used for the preliminary design of any structure. For a given value of yield displacement, the YFS are obtained from the Yield Displacement Chart. The suitability of the methodology proposed is illustrated by means of a simple case study of a concrete bridge pier.
Smoking and pancreatic cancer: a sex-specific analysis in the Multiethnic Cohort study
Authors: Gram Inger T. , Park Song-Yi , Wilkens Lynne R. , Le Marchand Loïc , Setiawan Veronica Wendy 
Published: October 2022

Abstract
Purpose
To examine whether the detrimental smoking-related association with pancreatic cancer (PC) is the same for women as for men.

Methods
We analyzed data from 192,035 participants aged 45–75 years, enrolled in the Multiethnic Cohort study (MEC) in 1993–1996. We identified PC cases via linkage to the Hawaii and California Surveillance, Epidemiology, and End Results Program cancer registries through December 2017.

Results
During a mean follow-up of 19.2 years, we identified 1,936 incident PC cases. Women smokers smoked on average less than men smokers. In multivariate Cox regression models, as compared with sex-specific never smokers, current smokers had a similar elevated risk of PC for women, hazard ratio (HR) 1.49 (95% CI 1.24, 1.79) and as for men, HR 1.48 (95% CI 1.22, 1.79) (pheterogeneity: 0.79). Former smokers showed a decrease in risk of PC for men within 5 years, HR 0.74 (95% CI 0.57, 0.97) and for women within 10 years after quitting, HR 0.70 (95% CI 0.50, 0.96), compared with their sex-specific current smokers. Both sexes showed a consistent, strong, positive dose–response association with PC for the four measures (age at initiation, duration, number of cigarettes per day, number of pack-years) of smoking exposure among current smokers and an inverse association for years of quitting and age at smoking cessation among former smokers (all ptrend’s < 0.001).

Conclusion
Although MEC women smoke on average less than their men counterparts, the smoking-related increase in PC risk and the benefits of cessation seem to be of similar magnitudes for women as for men.
Do Lefty and Righty Matter More Than Lefty Alone?
Authors: Gustafsson Johan E. , Kosonen Petra 
Published: October 2022

AbstractDerek Parfit argues that fission is prudentially better for you than ordinary death. But is having more fission products with good lives prudentially better for you than having just one? In this paper, we argue that it is. We argue that, if your brain is split and the halves are transplanted into two recipients (who both have good lives), then it is prudentially better for you if both transplants succeed than if only one of them does (other things being equal). This upshot rules out, among other things, that the prudential value of standing in the relation that matters in survival to multiple people is equal to their average well-being.
Prediction of customer’s perception in social networks by integrating sentiment analysis and machine learning
Authors: Ahmed Cherry , ElKorany Abeer , ElSayed Eman 
Published: October 2022

Abstract
Understanding the customer behavior and perception are important issues for motivating customer satisfaction in marketing analysis. Customer conversation with customer support services through social networks channel provides a wealth of information for understanding customer perception. Therefore, in this paper, a hybrid framework that integrated sentiment analysis and machine learning techniques is developed to analyze interactive conversations among customers and service providers in order to identify the change of polarity of such conversation. This framework aims to detect the conversation polarity switch as well as predict the sentiment of the end of the customer conversation with the service provider. This would help companies to improve customer satisfaction and enhance the customer engagement. The effectiveness of the proposed framework is measured by extracting a real dataset that expresses more than 5000 conversational threads between a customer service agent of an online retail service provider (AmazonHelp) and different customers using the retailer’s twitter public account for the duration of one month. Different classical and ensemble machine learning classifiers were applied, and the results showed that the decision trees outperformed all other techniques.
Machine learning guided alloy design of high-temperature NiTiHf shape memory alloys
Authors: Kankanamge Udesh M. H. U. , Reiner Johannes , Ma Xingjun , Gallo Santiago Corujeira , Xu Wei 
Published: October 2022

AbstractWith the increasing use of CubeSats in space exploration, the demand for reliable high-temperature shape memory alloys (HTSMA) continues to grow. A wide range of HTSMAs has been investigated over the past decade but finding suitable alloys by means of trial-and-error experiments is cumbersome and time-consuming. The present work uses a data-driven approach to identify NiTiHf alloys suitable for actuator applications in space. Seven machine learning (ML) models were evaluated, and the best fit model was selected to identify new alloy compositions with targeted transformation temperature (Ms), thermal hysteresis, and work output. Of the studied models, the K-nearest neighbouring ML model offers more reliable and accurate prediction in developing NiTiHf alloys with balanced functional properties and aids our existing understanding on compositional dependence of transformation temperature, thermal hysteresis and work output. For instance, the transformation temperature of NiTiHf alloys is more sensitive to Ni variation with increasing Hf content. A maximum Ms reduction rate of 6.12 °C per 0.01 at.% Ni is attained at 30 at.% Hf, and with a Ni content between 50 and 51 at.%.
Graphical abstract
Investigation of near-room and high-temperature thermoelectric properties of (Bi0.98In0.02)2Se2.7Te0.3/Bi2Te3 composite system
Authors: Hegde Ganesh Shridhar , Prabhu A. N. , Rao Ashok , Gurukrishna K. , Deepika Shanubhogue U. 
Published: October 2022

AbstractPolycrystalline composite samples of (Bi0.98In0.02)2Se2.7Te0.3/Bi2Te3 with different concentrations of Bi2Te3 such as 5%,10%,15% and 20% were prepared by the solid-state reaction technique. The X-Ray diffraction analysis has shown the hexagonal composite crystal structure with space group of $$R\overline{3 }$$

R

3
¯

m. Field emission scanning electronic microscope shows secondary particles on the surface of the samples. All the samples have shown the usual semi-conducting behaviour throughout the temperature range. It is observed that bismuth has been co-ordinated with 6 selenium atoms in (Bi0.98In0,02)2Se2.7Te0.3 compound and it has enormous selenium vacancies. The electrical resistivity represents the noteworthy result of the grain boundaries leading to the higher content of scattering centres in the polycrystalline composite samples. It is found that the electronegativity differences of In and Te, In and Se are less than Bi and Se, Bi and Te is the reason for the decrease in Seebeck coefficient in the compound containing 15% and 20% of Bi2Te3.
Indicators and participatory processes: a framework for assessing integrated climate vulnerability and risk as applied in Los Angeles County, California
Authors: Fleming Chloe S. , Regan Seann D. , Freitag Amy , Burkart Heidi 
Published: October 2022

AbstractClimate vulnerability research is enhanced by stakeholder engagement as coastal communities are increasingly vulnerable to climate-driven impacts, yet these impacts are rarely evenly distributed across space and stakeholder feedback is not always well incorporated into the process. While often used in applied management applications, integrated spatially explicit assessments of multi-faceted vulnerability and hazard less commonly appear in the scientific literature, especially those that are transferable across geographies and risk metrics. Since many geographies lack an integrated, stakeholder-driven assessment of multiple hazards and vulnerabilities within the same assessment, scientists with the National Oceanic and Atmospheric Administration’s National Centers for Coastal Ocean Science developed a transferable and integrated community vulnerability assessment framework (Framework) that relies primarily upon available secondary data and is supplemented with stakeholder-derived primary data. Using blended approaches in stakeholder engagement, we present the Framework’s six methodological steps as recently applied in Los Angeles County, California: iterative partner engagement, indicator and index development, vulnerability assessment, hazard assessment, risk assessment, and reengagement for adaptation action. We conclude that boundary-spanning organizations such as Sea Grant Extension programs can play a crucial role in participatory science and stakeholder needs assessments, and emphasize the need for continued stakeholder engagement in climate science.
Breakage Assessment of Lath-Like Crystals in a Novel Laboratory-Scale Agitated Filter Bed Dryer
Authors: Goh Wei Pin , Sinha Kushal , Nere Nandkishor K. , Ho Raimundo , Bordawekar Shailendra , Sheikh Ahmad , Ghadiri Mojtaba 
Published: October 2022

AbstractAgitated filter bed dryer is often the equipment of choice in the pharmaceutical industry for the isolation of potent active pharmaceutical ingredients (API) from the mother liquor and subsequent drying through intermittent agitation. The use of an impeller to promote homogeneous drying could lead to undesirable size reduction of the crystal product due to shear deformation induced by the impeller blades during agitation, potentially causing off-specification product and further downstream processing issues. An evaluation of the breakage propensity of crystals during the initial development stage is therefore critical. A new versatile scale-down agitated filter bed dryer (AFBD) has been developed for this purpose. Carbamazepine dihydrate crystals that are prone to breakage have been used as model particles. The extent of particle breakage as a function of impeller rotational speed, size of clearance between the impeller and containing walls and base, and solvent content has been evaluated. A transition of breakage behaviour is observed, where carbamazepine dihydrate crystals undergo fragmentation first along the crystallographic plane [00l]. As the crystals become smaller and more equant, the breakage pattern switches to chipping. Unbound solvent content has a strong influence on the breakage, as particles break more readily at high solvent contents. The laboratory-scale instrument developed here provides a tool for comparative assessment of the propensity of particle attrition under agitated filter bed drying conditions.