bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pickleball, Personality, and Eudaimonic Well-Being in Middle-Aged and Older Adults
Authors: Ryu Jungsu , Heo Jinmoo , Lee Sunwoo 
Published: February 2022

This study explored how personality and serious leisure activities, such as playing pickleball, contribute to eudaimonic well-being in middle-aged and older adults. Data were collected at pickleball events at the 2017 Huntsman World Senior Games from a convenience sample of 250 players aged between 50 and 91 years (M = 65.11, SD = 7.49). Of the five personality dispositions examined, conscientiousness (β = 0.32, p < .001), neuroticism (β = −0.22, p < .01), and openness to experience (β = 0.18, p < .01) were discovered to be significant predictors of eudaimonic well-being. Serious leisure also contributed to eudaimonic well-being (β = 0.28, p < .01). The findings of this study enhance the understanding of the behaviors exhibited by older adults and elucidate the positive impact exerted on eudaimonic well-being by personality and serious leisure.
The design of an open-source carbonate reservoir model
Authors: Costa Gomes Jorge , Geiger Sebastian , Arnold Daniel 
Published: February 2022

This work presents a new open-source carbonate reservoir case study, the COSTA model, that uniquely considers significant uncertainties inherent to carbonate reservoirs, providing a far more challenging and realistic benchmarking test for a range of geo-energy applications. The COSTA field is large, with many wells and large associated volumes. The dataset embeds many interacting geological and petrophysical uncertainties in an ensemble of model concepts with realistic geological and model complexity levels and varying production profiles. The resulting number of different models and long run times creates a more demanding computational challenge than current benchmarking models.
The COSTA model takes inspiration from the shelf-to-basin geological setting of the Upper Kharaib Member (Early Cretaceous), one of the most prolific aggradational parasequence carbonate formations sets in the world. The dataset is based on 43 wells and the corresponding fully anonymised data from the northeastern part of the Rub Al Khali basin, a sub-basin of the wider Arabian Basin. Our model encapsulates the large-scale geological setting and reservoir heterogeneities found across the shelf-to-basin profile, into one single model, for geological modelling and reservoir simulation studies.
The result of this research is a semi-synthetic but geologically realistic suite of carbonate reservoir models that capture a wide range of geological, petrophysical, and geomodelling uncertainties and that can be history-matched against an undisclosed, synthetic ‘truth case’. The models and dataset are made available as open-source to analyse several issues related to testing new numerical algorithms for geological modelling, uncertainty quantification, reservoir simulation, history matching, optimization and machine learning.

Supplementary material:
supplementary data associated with this article can be found in the data repository for the COSTA model available at
https://doi.org/10.17861/6e36e28d-50d9-4e31-9790-18db4bce6e5d
and supplementary material is available at
https://doi.org/10.6084/m9.figshare.c.5823571
Detecting Feedback Vertex Sets of Size
k
in
O
⋆
(2.7
k
) Time
Authors: Li Jason , Nederlof Jesper 
Published: February 2022

In the Feedback Vertex Set (FVS) problem, one is given an undirected graph
G
and an integer
k
, and one needs to determine whether there exists a set of
k
vertices that intersects all cycles of
G
(a so-called feedback vertex set). Feedback Vertex Set is one of the most central problems in parameterized complexity: It served as an excellent testbed for many important algorithmic techniques in the field such as Iterative Compression [Guo et al. (JCSS’06)], Randomized Branching [Becker et al. (J. Artif. Intell. Res’00)] and Cut&Count [Cygan et al. (FOCS’11)]. In particular, there has been a long race for the smallest dependence
f(k)
in run times of the type

O
⋆
(f(k))

, where the

O
⋆

notation omits factors polynomial in
n
. This race seemed to have reached a conclusion in 2011, when a randomized
O
⋆
(3

k

) time algorithm based on Cut&Count was introduced.

In this work, we show the contrary and give a

O
⋆
(2.7
k
)

time randomized algorithm. Our algorithm combines all mentioned techniques with substantial new ideas: First, we show that, given a feedback vertex set of size
k
of bounded average degree, a tree decomposition of width
(1-Ω (1))k
can be found in polynomial time. Second, we give a randomized branching strategy inspired by the one from [Becker et al. (J. Artif. Intell. Res’00)] to reduce to the aforementioned bounded average degree setting. Third, we obtain significant run time improvements by employing fast matrix multiplication.
Praluzatamab Ravtansine, a CD166-Targeting Antibody–Drug Conjugate, in Patients with Advanced Solid Tumors: An Open-Label Phase I/II Trial
Authors: Boni Valentina , Fidler Mary J. , Arkenau Hendrik-Tobias , Spira Alexander , Meric-Bernstam Funda , Uboha Nataliya , Sanborn Rachel E. , Sweis Randy F. , LoRusso Patricia , Nagasaka Misako , Garcia-Corbacho Javier , Jalal Shadia , Harding James J. , Kim Stella K. , Miedema Iris H.C. , Vugts Danielle J. , Huisman Marc C. , Zwezerijnen Gerben J.C. , van Dongen Guus A.M.S. , Menke van der Houven van Oordt C. Willemien , Wang Song , Dang Tam , Zein Ivan A. , Vasiljeva Olga , Lyman Susan K. , Paton Virginia , Hannah Alison , Liu Joyce F. 
Published: February 2022

Abstract

Purpose:
Praluzatamab ravtansine (CX-2009) is a conditionally activated Probody drug conjugate (PDC) comprising an anti-CD166 mAb conjugated to DM4, with a protease-cleavable linker and a peptide mask that limits target engagement in normal tissue and circulation. The tumor microenvironment is enriched for proteases capable of cleaving the linker, thereby releasing the mask, allowing for localized binding of CX-2009 to CD166. CX-2009 was evaluated in a phase I/II clinical trial for patients with advanced solid tumors.

Patients and Methods:
Eligible patients had metastatic cancer receiving ≥2 prior treatments. CX-2009 was administered at escalating doses every 3 weeks (0.25–10 mg/kg) or every 2 weeks (4–6 mg/kg). Primary objective was to determine the safety profile and recommended phase II dose (RP2D).

Results:
Of 99 patients enrolled, the most prevalent subtype was breast cancer (n = 45). Median number of prior therapies was 5 (range, 1–19). Dose-limiting toxicities were observed at 8 mg/kg every 3 weeks and 6 mg/kg every 2 weeks. On the basis of tolerability, the RP2D was 7 mg/kg every 3 weeks. Tumor regressions were observed at doses ≥4 mg/kg. In the hormone receptor–positive/HER2-nonamplified breast cancer subset (n = 22), 2 patients (9%) had confirmed partial responses, and 10 patients (45%) had stable disease. Imaging with zirconium-labeled CX-2009 confirmed uptake in tumor lesions and shielding of major organs. Activated, unmasked CX-2009 was measurable in 18 of 22 posttreatment biopsies.

Conclusions:
CD166 is a novel, ubiquitously expressed target. CX-2009 is the first conditionally activated antibody–drug conjugate to CD166 to demonstrate both translational and clinical activity in a variety of tumor types.
The Myth of Cleveland Abbe: A Review of a Manufactured History of the Creation of the National Weather Service
Authors: Romano Gregory F. , Uccellini Louis W. , Stremikis John R. 
Published: February 2022

Abstract
For more than a century, Cleveland Abbe was placed on a pedestal as meteorology’s solitary leader. Lauded by power brokers within the developing U.S. meteorological community, directors of the Weather Bureau (predecessor to today’s National Weather Service), and the American Meteorological Society, he was cited by many as the father of what is now the NWS, its first director, and issuer of its first forecast. However, a historiographical review of the literature that established the Abbe legend presented here shows the image held of Abbe today was actively manufactured; written, and supported by Abbe himself, his family, the Weather Bureau, and others within the AMS. We show that Abbe’s role in the creation of the nation’s first federal weather service was elevated while the contributions of others were actively downplayed. The latter applies particularly to Increase Lapham, who worked for two decades to demonstrate how a 24-h forecast of events could be generated from the collection and analysis of surface data, and whose active solicitation of Congressman Halbert Paine ultimately led to the creation of the first national weather service within the U.S. Army Signal Service on 9 February 1870. This paper is provided to shed a clearer light on those who contributed to the creation of what is now called the National Weather Service, which recently celebrated its 150th anniversary, and offer insights into how the Abbe myth was sustained as the AMS celebrated its anniversaries at 25-yr intervals over its 100-yr history.
Indian Monsoon Teleconnections and the Impact of Correcting Tropical Diabatic Heating
Authors: Swenson Erik T. , Straus David M. , Das Debanjana 
Published: February 2022

Abstract
The Indian summer monsoon is partly modulated by persistent remote forcing from the tropical Indo-Pacific, evident in the dominant observed teleconnection patterns, namely, El Niño–Southern Oscillation (ENSO) and the equatorial Indian Ocean Oscillation (EQUINOO). In the atmosphere, these teleconnections are presumably driven by diabatic heating, primarily associated with the release of latent heat in condensation with rainfall. However, in coupled atmosphere–ocean models, biases result in large systematic errors in tropical heating. This study seeks to understand the extent that teleconnections are forced by tropical heating and whether or not correcting tropical heating biases improves monsoon prediction skill. We examine a series of reforecasts made with the NCEP Climate Forecast System version 2 in which the “added heating” technique is applied to largely remove tropical heating biases. We isolate the ENSO and EQUINOO signals and examine the ability to reproduce and predict these teleconnections in the model run with and without tropical heating correction. Improving ENSO and EQUINOO-related heating does result in increased prediction skill in monsoon circulation teleconnection patterns. Prediction of other relevant tropical and subtropical circulation indices is improved; however, the impact on the Indian monsoon as a whole is limited. EQUINOO exhibits large internal variability in the model, and despite imposing realistic EQUINOO heating, the monsoon circulation is relatively insensitive in the model. This suggests that either the EQUINOO teleconnection in nature does not emerge as a forced response to tropical heating, and/or the model is unable to reproduce the relationship due to separate deficiencies.

Significance Statement
India receives over 80% of its annual rainfall during the summer in association with the monsoon. A strong socioeconomic dependence on agriculture makes India sensitive to year-to-year variations in monsoon rainfall, thus predicting and understanding such variations is of great value. Coincident changes in tropical atmospheric heating (and cooling) may be more predictable and presumably impact the monsoon; however, causality has yet to be demonstrated and quantified, particularly for the tropical Indian Ocean. This motivates our modeling study to diagnose the role of tropical heating for the Indian monsoon and whether or not correcting heating errors improves monsoon prediction.
Entrainment in a Simulated Supercell Thunderstorm. Part II: The Influence of Vertical Wind Shear and General Effects upon Precipitation
Authors: Jo Enoch , Lasher-Trapp Sonia 
Published: February 2022

Abstract
Supercell thunderstorms can produce heavy precipitation, and an improved understanding of entrainment may help to explain why. In Part I of this series, various mechanisms of entrainment were identified in the rotating stage of a single simulated supercell thunderstorm. The current study examines the strength and effectiveness of these mechanisms as a function of the environmental vertical wind shear in eight different supercell simulations. Entrainment is calculated directly as fluxes of air over the surface of the storm core; tracers are used to assess the resulting dilution of the moistest air ingested by the storm. Model microphysical rates are used to compare the impacts of entrainment on the efficiency of condensation/deposition of water vapor on hydrometeors within the core, and ultimately, upon precipitation production. Results show that the ascending “ribbons” of horizontal vorticity wrapping around the updraft contribute more to entrainment with increasing vertical wind shear, while turbulent eddies on the opposite side of the updraft contribute less. The storm-relative airstream introduces more low-level air into the storm core with increasing vertical wind shear. Thus, the total entrainment increases with increasing vertical wind shear, but the fractional entrainment decreases, yielding an increase in undiluted air within the storm core. As a result, the condensation efficiency within the storm core also increases with increasing vertical wind shear. Due to the increase in hydrometeors detrained aloft and the resulting enhanced evaporation as they fall, the precipitation efficiency evaluated using surface rainfall decreases with increasing vertical wind shear, as found in past studies.
Wind-Forced Variability of the Zonal Overturning Circulation
Authors: Spall Michael A. 
Published: February 2022

AbstractThe mechanisms of wind-forced variability of the zonal overturning circulation (ZOC) are explored using an idealized shallow water numerical model, quasigeostrophic theory, and simple analytic conceptual models. Two wind-forcing scenarios are considered: midlatitude variability in the subtropical/subpolar gyres and large-scale variability spanning the equator. It is shown that the midlatitude ZOC exchanges water with the western boundary current and attains maximum amplitude on the same order of magnitude as the Ekman transport at a forcing period close to the basin-crossing time scale for baroclinic Rossby waves. Near the equator, large-scale wind variations force a ZOC that increases in amplitude with decreasing forcing period such that wind stress variability on annual time scales forces a ZOC ofO(50) Sv (1 Sv ≡ 106m3s−1). For both midlatitude and low-latitude variability the ZOC and its related heat transport are comparable to those of the meridional overturning circulation. The underlying physics of the ZOC relies on the influences of the variation of the Coriolis parameter with latitude on both the geostrophic flow and the baroclinic Rossby wave phase speed as the fluid adjusts to time-varying winds.Significance StatementThe purpose of this study is to better understand how large-scale winds at mid- and low latitudes move water eastward or westward, even in the deep ocean that is not in direct contact with the atmosphere. This is important because these currents can shift where heat is stored in the ocean and if it might be released into the atmosphere. It is shown that large-scale winds can drive rapid cross-basin transports of water masses, especially so at low latitudes. The present results provide a guide on what controls this motion and highlight the importance of large-scale ocean waves on the water movement and heat storage.
Myricetin (3,3′,4′,5,5′,7-hexahydroxyflavone) prevents ethanol-induced biochemical and inflammatory damage in the liver of Wistar rats
Authors: Ahmad Sheikh Bilal , Rashid Shahzada Mudaisr , Wali Adil Farooq , Ali Shafat , Rehman Muneeb U , Maqbool Mir Tahir , Nadeem Ahmed , Ahmad Sheikh Fayaz , Siddiqui Nahid 
Published: February 2022

Purpose: The current investigation was carried out to evaluate the efficacy of myricetin in ethanol-induced liver toxicity in Wistar rats. Research Design: Twenty-four rats were randomly divided into four groups with six animals per group. Group-I animals were administered with vehicle (distilled water), Group II, III, and IV were treated orally with sequential (per week) increase in the dose of ethanol (5, 8, 10, and 12 g/kg b wt per week in each group) for 28 days. Myricetin was treated orally to Group-III and IV animals at the respective doses of 25 mg/kg b wt. and 50 mg/kg b wt. Results: Our results showed that myricetin prevented hepatotoxicity by modulating the production of free radicals, ethanol metabolizing enzymes, and inflammatory markers in vivo. Myricetin also helped maintain lipid membrane integrity, oxidant-antioxidant status, and histoarchitecture. Ethanol administration caused elevation in XO, ADH, and CYP2E1 in hepatic tissue, which significantly normalized with myricetin administration. After ethanol administration, there was a steep increase in the hepatotoxicity biomarkers, including ALT, MDA, and AST. The level of cytotoxicity marker LDH also increased after ethanol administration; myricetin administration decreased the level of all these markers. Moreover, myricetin treatment also reduced ethanol-induced inflammatory markers such as NF-κB and IL-6. Conclusion: Findings from the current study demonstrate that myricetin administration prevents alcohol-induced hepatic injury by influencing the metabolism of ethanol, inhibiting oxidative stress, maintaining lipid profile, and suppressing inflammatory markers.
Missed Opportunities? An Observational Analysis of Lung Cancer Screening Utilization Amongst Patients With Lung Cancer
Authors: Olazagasti Coral , Ehrlich Matthew , Kohn Nina , Aviles Karen , Hoilett Aldane , Seetharamu Nagashree 
Published: February 2022

Lung cancer (LC) is the leading cause of cancer-related deaths worldwide. The U.S. Preventive Services Task Force (USPSTF) and National Comprehensive Cancer Network (NCCN) recommend annual low-dose CT chest (LDCT) for LC screening in high-risk adults who meet appropriate criteria, which primarily focus on age and smoking history. Despite this, screening rates remain low and patients with LC are typically diagnosed at a later stage. We conducted a single-center retrospective analysis of patients with an established diagnosis of lung cancer to evaluate if screening guidelines were appropriately followed before the cancer diagnosis. Patients diagnosed with LC between 2016 and 2019 were included in the analysis. Charts were reviewed for demographics, detailed smoking history, as well as histology and stage of LC. Associations between categorical factors and screening were examined using the chi-square test. Associations between continuous and ordinal factors and screening were examined using the Mann–Whitney test. A total of 530 charts were reviewed, of which 52% met NCCN criteria and 35% met USPSTF criteria. Only 4.0% and 4.8% of patients who met NCCN and USPSTF criteria, respectively, underwent screening. There was a significant association between staging at diagnosis and screening with LDCT. All the patients who had screening CT scans were diagnosed at localized stages of lung cancer in both NCCN and USPSTF groups compared to 49.1% and 48% in eligible subjects that did not undergo screening, respectively. Our study showed that despite established guidelines for LC screening and insurance coverage, a vast majority of screening-eligible LC patients have never had LDCT. We found that patients who underwent screening as per guidelines were diagnosed at earlier stages of the disease. Ongoing efforts to increase awareness and adherence to LC screening guidelines are needed to improve early detection and reduce LC mortality.
Platelet Dysfunction in Cardiac Surgery: When is the Best Time to Assess It? An Observational Single Center Study
Authors: Auci Elisabetta , Vendramin Igor , Barbariol Federico , Riccardi Ilaria , Gigante Andrea , Baroselli Antonio , Bove Tiziana , Bassi Flavio , Vetrugno Luigi , Livi Ugolino 
Published: February 2022

Purpose. Cardiac surgery is characterized by a high risk of complications related to perioperative bleeding. Guidelines suggest the use of local algorithms based on perioperative point-of-care tests to assess and manage potential coagulation abnormalities. We investigated whether heparin reversal administration affects the adenosine-5-diphosphate (ADP) test values, thus identifying the earliest time point following cardio-pulmonary bypass that permits the promptest detection and treatment of potential platelet dysfunctions. Methods. This was a retrospective, single-center, observational study enrolling cardiac surgery patients requiring cardiac bypass. ADP-tests at 4 different time-points during surgery (T0: baseline, T1: at aortic de-clamping, T2: 10 minutes after protamine administration, and T3: at the end of surgery) were performed. Results. 63 patients undergoing elective cardiac surgery were studied. Baseline ADP-test values were almost constantly greater than intraoperative values, and end of surgery values were often greater than previous intraoperative values. The only difference that proved to be not statistically significant was between T1 and T2, with a clinically insignificant mean difference of −.2 U (95%CI of difference: −6.9 - 6.5 U). There was no correlation between the variation in ADP-test values pre- and post-protamine administration and the protamine-to-heparin ratio. Conclusion. The results of the present study support the hypothesis that the ADP-test could be performed early, at aortic de-clamping before protamine administration. This approach allows for the promptest assessment of a potential impairment in platelet function, and its timely correction.
Proximal Interphalangeal Joint Congruity: A Biomechanical Study
Authors: Levy Kenneth H. , Kurtzman Joey S. , Horowitz Evan H. , Dar Qurratul-Ain , Hayes Westley T. , Koehler Steven M. 
Published: February 2022

Background: Surgical approaches to the proximal interphalangeal (PIP) joint often require disruption of soft tissue stabilizers. Additionally, PIP joint injuries frequently result in soft tissue disruption. This study evaluates the necessity of repairing soft tissue stabilizers by assessing their role in maintaining native joint congruity. Methods: Eight specimens were used to evaluate congruity at 0° and 30° flexion when loaded with 2 N of valgus force. This was performed in the native joint and after sequential sectioning of the surrounding ligaments in order: volar plate (VP), radial collateral ligament (CL), and ulnar CL. The skin flap was sutured with the ligaments unrepaired and the load was reapplied. Radiographs were taken after each load and used to measure the joint line convergence angle (JLCA). Results: Mean JLCA increased in both degrees of flexion after ligaments were sectioned but was only significantly different from the native joint after the VP was disrupted along with 1 CL. Joint congruity improved following repair of the skin flap in both degrees of flexion but was not significant. Joints were more congruent in 30° flexion for all subgroups, but none were significantly different compared to 0° flexion. Conclusions: Disruption of the VP is insufficient to significantly alter PIP joint congruity. While sectioning of both the VP and CLs resulted in a statistically significant change in joint congruity, mean JLCA demonstrated changes of minor clinical significance. The osseous anatomy of the phalanges imparts inherent stability that maintains a congruent joint despite loss of the soft tissue stabilizers.