bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic Reference Range for Aripiprazole in Schizophrenia Revised: a Systematic Review and Metaanalysis
Authors: Hart Xenia M. , Hiemke Christoph , Eichentopf Luzie , Lense Xenija M. , Clement Hans Willi , Conca Andreas , Faltraco Frank , Florio Vincenzo , Grüner Jessica , Havemann-Reinecke Ursula , Molden Espen , Paulzen Michael , Schoretsanitis Georgios , Riemer Thomas G. , Gründer Gerhard 
Published: October 2022

Abstract
Rationale
While one of the basic axioms of pharmacology postulates that there is a relationship between the concentration and effects of a drug, the value of measuring blood levels is questioned by many clinicians. This is due to the often-missing validation of therapeutic reference ranges.

Objectives
Here, we present a prototypical meta-analysis of the relationships between blood levels of aripiprazole, its target engagement in the human brain, and clinical effects and side effects in patients with schizophrenia and related disorders.

Methods
The relevant literature was systematically searched and reviewed for aripiprazole oral and injectable formulations. Population-based concentration ranges were computed (N = 3,373) and pharmacokinetic influences investigated.

Results
Fifty-three study cohorts met the eligibility criteria. Twenty-nine studies report blood level after oral, 15 after injectable formulations, and nine were positron emission tomography studies. Conflicting evidence for a relationship between concentration, efficacy, and side effects exists (assigned level of evidence low, C; and absent, D). Population-based reference ranges are well in-line with findings from neuroimaging data and individual efficacy studies. We suggest a therapeutic reference range of 120–270 ng/ml and 180–380 ng/ml, respectively, for aripiprazole and its active moiety for the treatment of schizophrenia and related disorders.

Conclusions
High interindividual variability and the influence of CYP2D6 genotypes gives a special indication for Therapeutic Drug Monitoring of oral and long-acting aripiprazole. A starting dose of 10 mg will in most patients result in effective concentrations in blood and brain. 5 mg will be sufficient for known poor metabolizers.
CsPbBr3 deposited by laser ablation: effects of post-growth aging, oxygen adsorption and annealing on film properties
Authors: Cesaria Maura , Quarta Gianluca , Guascito Maria Rachele , Mazzeo Marco , Marra Marcella , Provenzano Chiara , Aziz Muhammad Rizwan , Martino Maurizio , Calcagnile Lucio , Caricato Anna Paola 
Published: October 2022

AbstractAll-inorganic perovskites are widely investigated as a new generation of materials thanks to their superior optoelectronic properties and better stability than hybrid organic–inorganic perovskites. In particular, cesium lead bromide (CsPbBr3) exhibits advantageous properties for numerous applicative fields (photovoltaics, light-emitting diodes, photodetectors, lasing, field effect transistors, and ionizing radiation detectors). The performance of CsPbBr3 being critically dependent on the deposition technique, proper understanding and optimization of the fabrication process are demanding. Despite the well-known potentiality of the Pulsed Laser Deposition (PLD) technique in depositing films with complex stoichiometry, a very limited number of literature studies report on the successful deposition of CsPbBr3 films by PLD. Recently, the authors disclosed the impact of the uneven masses of Cs, Pb, and Br on the film stoichiometry and guidelines to recover the desired composition. Herein, we exploit stoichiometric mechano-chemically synthesized targets to deposit, by nanosecond-PLD (λ = 248 nm, τ = 20 ns, room temperature, fluence of 1 J/cm2), CsPbBr3 films to be studied following time aging, thermal heating and exposure to high relative humidity. Even in the presence of the characteristic absorption peak at ~ 520 nm, the freshly deposited film shows no photoluminescence. Photoluminescence is switched on by thermal annealing (at 250 and 350 °C) or after a few days (at least 15) of exposure to air and it persists over time. Films present interesting morphology evolution and oxygen adsorption following heating.
Quantifying skeletal density at high temporal resolution in massive scleractinian corals by using two-dimensional grid-scanning gamma densitometry
Authors: Zoppe Simon Felix , Deveaux Michael , Gischler Eberhard 
Published: October 2022

Abstract
The quantification of skeletal density in massive scleractinians is necessary for a better understanding of skeletal growth in reef-forming corals. However, skeletal density is difficult to quantify and requires sophisticated analytical techniques. In this study, two-dimensional grid-scanning gamma densitometry is used for the first time, to quantify skeletal density fluctuations at higher temporal (intra-annual) resolution as compared to previous annual bulk densities determined with this approach. For testing this application and to evaluate its use for being a tool in coral sclerochronology, a colony of the widespread Atlantic massive coral Orbicella faveolata from the central Belize Barrier Reef (Central America) is herein investigated. In the studied coral, temporal resolution of individual density values corresponds to an approximately bi-weekly resolution. A long-term decline in (intra-)annual skeletal density is observed combined with reduced calcification rates. This indicates a limitation in the capability for skeletal formation in O. faveolata corals within the central Belize Barrier Reef, expressed in reduced skeletal carbonate accretion. In general, time series analyses and statistical correlations of the obtained high-resolution density datasets with skeletal growth patterns (linear extension rates, calcification rates) and geochemical (δ13C, δ18O) data reveal a complex interplay of environmental parameters, which might have controlled the skeletal density in the studied coral.
Screw placement in arthroscopically assisted osteosynthesis of radial head fractures using a reference k-wire in the radiocapitellar joint: a cadaveric study
Authors: Camenzind Roland S. , Cucchi Davide , Leschinger Tim , Hackl Michael , Müller Lars P. , Wegmann Kilian 
Published: October 2022

AbstractPurposeThe optimal screw placement in arthroscopically assisted fixation of radial head fractures is still an issue and no guiding methods have been evaluated in the recent literature. The study hypothesis was that using a “reference k-wire” percutaneously inserted in and parallel to the radiocapitellar joint would enable to achieve a trajectory more parallel to the radial head articular surface as compared to a free-hand k-wire placement.MethodsArthroscopically assisted placement of a k-wire in the radial head was performed in seven fresh-frozen human cadaver specimens by three surgeons. Three different techniques were evaluated: freehand drilling (technique A), placement using a “reference” k-wire in the radiocapitellar joint as a reference without (technique B), and with the AO parallel k-wire guide (technique C). Radiographs from all procedures were obtained and the inclination angle “α” between the k-wire and the articular surface of the radial head was measured and compared among the techniques.ResultsAngles of 84 radiographs were obtained and showed a mean α angle of 30.1° ± 13° for technique A, 5.7° ± 4.5° for technique B, and 5.4° ± 3.7° for technique C. The angle α was significantly higher with technique A as compared to B (p < 0.0001) and C (p < 0.0001). There was no difference between methods B and C (n.s.). No difference was observed among the surgeons for all three methods (p = 0.66).ConclusionWith the use of an additional “reference” k-wire placed in the radiocapitellar joint, the guiding k-wire for screw drilling can be placed almost parallel to the radial head joint line with limited variability and a good reproducibility during arthroscopically assisted radial head fracture fixation.Clinical relevanceThe here-presented method of an additional, percutaneous introduced “reference” k-wire is easily applicable and helpful to achieve parallel screw placement during arthroscopically assisted radial head fracture fixation.Level of evidenceIV, biomechanical cadaver study
Long-term survival analysis of cementless large-diameter head metal-on-metal total hip arthroplasty
Authors: Holappa Elli , Kettunen Jukka , Miettinen Hannu , Kröger Heikki , Miettinen Simo 
Published: October 2022

Abstract
Introduction
The aim of this retrospective study was to study the long-term survival and reasons for revisions of a single-type, large-diameter head (LDH) metal-on-metal (MoM) implant. A special study interest was to find the threshold level for revision in terms of adverse reaction to metal debris (ARMD).

Materials and Methods
In this cohort study, we retrospectively reviewed 234 patients (253 hips) who received 38 mm head size LDH MoM total hip arthroplasties (THAs) between 01 January 2004 and 31 December 2009 at our institution. Patient symptoms, conventional radiographs, magnetic resonance imaging (MRI) findings and whole blood metal ions were studied.

Results
The median follow-up time was 11.5 years. The Kaplan–Meier cumulative survival estimate of the implant was 89.6% at 10 years and 82.9% at 14.6 years. Overall, 34/253 (13.4%) hips were revised during the follow-up period and of these; 19/34 (55.9%) were revised due to ARMD. The prevalence of ARMD was 12.4% (29/234 patients).

Conclusions
The survival of the implant was on a moderate level as the 10-year cumulative survival rate was 89.6%. The exact threshold level for ARMD revision cannot be determined due to multiple variables affecting factors in re-operation decision-making.
An efficient algorithm for rigid/deformable contact interaction based on the dual mortar method
Authors: Carvalho R. Pinto , Carneiro A. M. Couto , Pires F. M. Andrade , Popp A. 
Published: October 2022

AbstractIn a wide range of practical problems, such as forming operations and impact tests, treating one of the contacting bodies as a rigid obstacle is an excellent approximation to the physical phenomenon. In this work, the well-established dual mortar method is adopted to enforce interface constraints in the finite deformation frictionless contact of deformable bodies and rigid obstacles. The efficiency of the non-linear contact algorithm proposed here is based on two main contributions. Firstly, the weighted gap function is modified such that it retains the signal of the discrete gap function. Within the context of rigid/deformable contact, this unlocks a significant simplification by removing the need to explicitly evaluate the dual basis functions. The corresponding first-order interpolation is presented in detail. Particular focus is, then, placed on the extension for second-order interpolation by employing a piecewise linear interpolation scheme, which critically retains the geometrical information of the finite element mesh. Secondly, a new definition for the nodal orthonormal moving frame attached to each contact node is suggested. It reduces the geometrical coupling between the nodes and consequently decreases the stiffness matrix bandwidth. The proposed contributions decrease the computational complexity of dual mortar methods for rigid/deformable interaction, especially in the three-dimensional setting, while preserving accuracy and robustness.
Evaluating an augmented reality interface for sailing navigation: a comparative study with a immersive﻿ virtual reality simulator
Authors: Laera Francesco , Manghisi Vito Modesto , Evangelista Alessandro , Uva Antonio Emmanuele , Foglia Mario Massimo , Fiorentino Michele 
Published: October 2022

AbstractSailing navigation is an activity that requires acquiring and processing information from the surrounding environment. The advancement of technology has enabled sailboats to have an increasing number of onboard sensors that make sailing more user-friendly. However, data provided by these sensors are still visualized on 2D digital displays that imitate traditional analog interfaces. Although these displays are strategically placed on the sailboat, the user needs to divert attention from the primary navigation task to look at them, thus spending a significant amount of cognitive resources. AR-based technologies have the potential to overcome these limitations by displaying information registered in the real environment, but there are no studies in the literature for validating the effectiveness of this technology in the field of sailing. Thus, we designed a head-mounted display AR-based interface to assist users in monitoring wind data to avoid user diversion from the primary task of sailing. We conducted a user study involving 45 participants in an Immersive Virtual Reality simulated environment. We collected objective and subjective measures to compare the AR-based interface with a traditional data visualization system. The AR-based interface outperformed the traditional data visualization system regarding reaction time, cognitive load, system usability, and user experience.
Genicular nerve block in juvenile idiopathic arthritis: a randomized clinical trial
Authors: Radwan A. , Ohrndorf S. , Aly H. , Hamed M. , Khalifa A. , Elsaman A. M. 
Published: October 2022

Abstract

Objectives
This study aimed at evaluating the effect of genicular nerve block (GNB) in juvenile idiopathic arthritis (JIA) patients with persistent unilateral knee arthritis on pain, inflammatory parameters, function, and range of motion.

Methods
A total of 104 JIA patients were diagnosed according to the International League Against Rheumatism (ILAR) criteria with persistent unilateral knee arthritis. They were allocated randomly into 2 groups: group 1 treated with GNB, while group 2 was treated with intra-articular triamcinolone (TA) only. Visual analogue scale (VAS) on pain, sonography of large joints in rheumatology (SOLAR) scoring system, and Lysholm scores were assessed at 0-, 2-, and 12-week intervals. Swelling and tenderness were clinically evaluated semi-quantitatively (0-3) at the same time intervals.

Results
VAS pain, tenderness, swelling, and SOLAR grey scale (GS) and power Doppler (PD) scores were significantly reduced after 2 weeks in both groups (p < 0.05). This was greater in the GNB group regarding VAS and tenderness, while SOLAR and swelling were stronger reduced in TA group. After 12 weeks, all outcome measures showed lower values in the GNB group compared to TA, and this was significant regarding VAS pain. Moreover, Lysholm functional score was significantly increased in both groups at both intervals; and higher values were seen in the TA group compared to GNB after 2 weeks.

Conclusion
GNB was able to control pain and improve function and inflammation of the knee joint in JIA patients. Though steroid attained better results after 2 weeks, GNB achieved an equivalent longer-term improvement after 12 weeks.

Trial registration identifying number
NCT04687930.

Key Points• Persistent knee arthritis treatment in JIA is always challenging.• GNB was approved for treatment of pain in knee osteoarthritis.• GNB in the present study succeeded to control active knee arthritis and this effect was comparable to intra-articular steroid injection.
Control charts for measurement error models
Authors: Golosnoy Vasyl , Hildebrandt Benno , Köhler Steffen , Schmid Wolfgang , Seifert Miriam Isabel 
Published: October 2022

AbstractWe consider a linear measurement error model (MEM) with AR(1) process in the state equation which is widely used in applied research. This MEM could be equivalently re-written as ARMA(1,1) process, where the MA(1) parameter is related to the variance of measurement errors. As the MA(1) parameter is of essential importance for these linear MEMs, it is of much relevance to provide instruments for online monitoring in order to detect its possible changes. In this paper we develop control charts for online detection of such changes, i.e., from AR(1) to ARMA(1,1) and vice versa, as soon as they occur. For this purpose, we elaborate on both cumulative sum (CUSUM) and exponentially weighted moving average (EWMA) control charts and investigate their performance in a Monte Carlo simulation study. The empirical illustration of our approach is conducted based on time series of daily realized volatilities.
A family of distances for preference–approvals
Authors: Albano Alessandro , García-Lapresta José Luis , Plaia Antonella , Sciandra Mariangela 
Published: October 2022

AbstractA preference–approval on a set of alternatives consists of a weak order on that set and, additionally, a cut-off line that separates acceptable and unacceptable alternatives. In this paper, we propose a new method for defining the distance between preference–approvals taking into account jointly the disagreements in preferences and approvals for each pair of alternatives. The proposed distance is compared to the existing distance functions to deal with clustering problems. Specifically, we prove that our metric improves the estimated clusters in terms of both stability and accuracy.
Biotic resistance or invasional meltdown? Diversity reduces invasibility but not exotic dominance in southern California epibenthic communities
Authors: Beshai Ryan A. , Truong Danny A. , Henry Amy K. , Sorte Cascade J. B. 
Published: October 2022

AbstractHigh community diversity may either prevent or promote the establishment of exotic species. The biotic resistance hypothesis holds that species-rich communities are more resistant to invasion than species-poor communities due to mechanisms including greater interspecific competition. Conversely, the invasional meltdown hypothesis proposes that greater exotic diversity increases invasibility via facilitative interactions between exotic species. To evaluate the degree to which biotic resistance or invasional meltdown influences marine community structure during the assembly period, we studied the development of marine epibenthic “fouling” communities at two southern California harbors. With a focus on sessile epibenthic species, we found that fewer exotic species established as total and exotic richness increased during community assembly and that this effect remained after accounting for space availability. We also found that changes in exotic abundance decreased over time. Throughout the assembly period, gains in exotic abundance were greatest when space was abundant and richness was low. Altogether, we found greater support for biotic resistance than invasional meltdown, suggesting that both native and exotic species contribute to biotic resistance during early development of these communities. However, our results indicate that biotic resistance may not always reduce the eventual dominance of exotic species.
Graphene oxide modified with carboxymethyl cellulose for high adsorption capacities towards Nd(III) and Ce(III) from aqueous solutions
Authors: Abd-Elhamid A. I. , Abu Elgoud E. M. , Aly H. F. 
Published: October 2022

AbstractThis work addresses a simple method to functionalize graphene oxide with sodium carboxymethyl cellulose using tetraethyl orthosilicate as a linker for rapid and significant removal of Nd(III) and Ce(III) from aqueous solutions. The prepared composite (GO–CMC) was characterized by different techniques to confirm the modification and adsorption process. The sorption performance of the GO–CMC was evaluated using Nd(III) and Ce(III) as absorbent materials. The experimental results demonstrated that the sorption process was excellently fitted by the pseudo-second-order kinetic model. The adsorption results were also analyzed by different isotherm models. According to the Langmuir isotherm model, the experimental sorption capacities at pH 3.0 was 661.21 and 436.55 mg/g for Nd(III) and Ce(III), respectively. The thermodynamic results indicated that the sorption process of the two examined metal ions was endothermic and spontaneous. The regenerated GO–CMC composite has a similar removal percentage to the original composite. These results confirmed that the prepared composite (GO–CMC) could be used as an effective adsorbent for Nd(III) and Ce(III) from certain multielement solutions.
An adaptive read/write optimized algorithm for Ceph heterogeneous systems via performance prediction and multi-attribute decision making
Authors: Li Zhike , Wang Yong 
Published: October 2022

AbstractThe advent of the Big Data era has brought considerable challenges to storing and managing massive data. Moreover, distributed storage systems are critical to the pressure and storage capacity costs. The Ceph cloud storage system only selects data storage nodes based on node storage capacity. This node selection method results in load imbalance and limited storage scenarios in heterogeneous storage systems. Therefore, we add node heterogeneity, network state, and node load as performance weights to the CRUSH algorithm and optimize the performance of the Ceph system by improving load balancing. We designed a cloud storage system model based on Software Defined Network (SDN) technology. This system model can avoid the tedious configuration and significant measurement overhead required to obtain network status in traditional network architecture. Then we propose adaptive read and write optimization algorithms based on SDN technology. The Object Storage Device (OSD) is initially classified based on the Node Heterogeneous Resource Classification Strategy. Then the SDN technology is used to obtain network and load conditions in real-time and an OSD performance prediction model is built to obtain weights for performance impact factors. Finally, a mathematical model is proposed for multi-attribute decision making in conjunction with the OSD state and its prediction model. Furthermore, this model is addressed to optimize read and write performance adaptively. Compared with the original Ceph system, TOPSIS_PA improves the performance of reading operations by 36%; TOPSIS_CW and TOPSIS_PACW algorithms improve the elastic read performance by 23 to 60% and 36 to 85%, and the elastic write performance by 180 to 468% and 188 to 611%, respectively.
‘I have used up my entire youth in the bush’: the Comités de Autodefensa during and after the Peruvian internal armed conflict
Authors: Willems Eva 
Published: October 2022

AbstractYoungsters participate as combatants at the forefront of armed conflicts around the globe, be it as part of state forces, as members of rebel groups, or as drivers of armed civilian resistance. This contribution explores the social trajectories of (ex-)civil self-defense militia members in Peru who fought alongside the state forces to defeat the Maoist rebels of Shining Path in the 1980 and 1990s. On the one hand, by taking the Peruvian Comités de Autodefensa (CAD) as a somewhat atypical case-study, the article aims to enhance a more nuanced understanding of youth as drivers of and participants in civil war violence which transcends the victim-perpetrator dichotomy. On the other, by analyzing the social trajectories of CAD leaders and members from their youth until the present, it seeks to gain insight into ex-combatants’ claims for recognition, reparation and citizenship in the aftermath of armed conflict. The trajectories of the CAD members demonstrate how the morality of soldiering, steered by ideas about masculinity, militarism and patriotism, gets intertwined with structural societal conditions such as the lack of educational and economic perspectives for youngsters, and the state’s failure to provide protection and security against rebel group violence to those who might need it most. In the aftermath of the conflict, militia service and the corresponding macho warrior identity form a basis of demands for inclusion by an historically marginalized rural population group. The findings on the Peruvian self-defense committees presented in this article have several implications for research and policy in the fields of Transitional Justice and Disarmament, Demobilization and Reintegration, and open both thematic and conceptual avenues for further research into civilian participation in armed conflicts around the globe.