bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combination of Clavicular Hook Plate with Coracoacromial Ligament Transposition in Treatment of Acromioclavicular Joint Dislocation
Authors: Tuxun Aikebaier , Keremu Ajimu , Aila Pazila , Abulikemu Maimaitiaili , Xie Zengru , Ababokeli Palati 
Published: February 2022

ObjectiveTo evaluate the clinical efficacy of Arbeitsgemeinschaft für Osteosynthesefragen (AO) clavicular hook plate (CHP) combined with coracoacromial ligament transposition for Rockwood III‐V dislocation of AC joint, providing an alternative choice for AC joint dislocation treatment.MethodsTwenty‐five patients diagnosed with Rockwood III‐V dislocation of acromioclavicular (AC) joint, including 18 males and seven females, aged 43.5 ± 2.4 years old on average, who had undergone open reduction and AO CHP in combination with coracoacromial (CC) ligament transposition between January 2010 and December 2015, were retrospectively analyzed. Among them, 17 cases were diagnosed as type III, five cases were type IV, and three cases were type V. The surgery mainly included three main steps: bone flap incision, drilling in the clavicle, and hook plate fixation and AC joint reposition. The treatment efficacy was evaluated through clinical examinations and imaging studies for the shoulder joint, including gross observation and measuring coracoid clavicle distance (CC‐Dist) using orthophoria X‐ray before and 1 year after the surgery, and University of California (UCLA) shoulder rating scale.ResultsAll the patients were followed up three to four times in 18 months (12–24 months) on average, and the UCLA rating results showed that there were 17 excellent cases (68%), five good cases (20%), and three fair cases (12%). The CC‐Dist values after the surgery reduced to 9.7 ± 0.7 mm, which was significantly (P < 0.05) lower compared to that before the surgery (15.8 ± 1.6 mm). Most (88%) of the cases showed almost normal joint function and good anatomical arrangement of the acromioclavicular joint, without any secondary dislocation, and for them, 12 ± 2 weeks on average were needed to regain the normal function of shoulder joint movement.ConclusionDue to the stable fixation, fewer complications, and satisfactory therapeutic effect with great clinical value, the combination of AO CHP and CC ligament transposition is expected to be used for treating Rockwood III‐V dislocation of AC joint.
Altered event processing in persons with Parkinson’s disease
Authors: Wyrobnik Michelle , van der Meer Elke , Klostermann Fabian 
Published: February 2022

AbstractPersons with Parkinson’s disease (PD) often show particular problems in seemingly simple routines despite relatively preserved cognitive function. We therefore investigated the processing of everyday events on behavioral and neurophysiological levels in a PD and control group. The participants had to indicate via button press whether three sequentially presented sub‐events described a previously defined event (e.g., going grocery shopping). Sub‐event sequences were either correct or included an event that did not belong to the event (content violation), or events were chronologically wrong (temporal violation). During task execution event‐related potentials (ERPs) were recorded. Generally, the PD group showed less accurate performance independently from task conditions, and reaction times to temporal violations were particularly slow compared to the control group. Regarding ERP results, the control group showed a right lateralized N400 effect in response to content violations, which was absent in the PD group indicating altered content event processing. Concerning the reanalysis of content event violations, the expression of late positive components (LPCs) was similar between both groups. Upon temporal violations, both groups also showed a LPC with a tendentially earlier onset in the PD group, resembling positive components indicative of novelty processing. Together, these findings suggest poor event prediction in PD, which may originate from weak event representation or retrieval and possibly relate to prevalent behavioral dysfunctions in everyday life in PD.
Amikacin prevents platelet aggregation in feline venous blood samples
Authors: Engelmann Ana M. , Veleda Patrícia A. , Mello Camila B. E. , Dutra Lara S. , Mann Thaís R. , Bueno Andressa , Krause Alexandre , de Andrade Cinthia M. 
Published: February 2022

AbstractIntroductionPhysiologically, feline platelets are more reactive and prone to aggregation, which interferes with platelet counts using automated counters and manual methods. The use of aminoglycoside amikacin in association with EDTA has proven to be efficient in preventing platelet aggregates in cases of pseudo thrombocytopenia (PTP) in people.ObjectivesThis study evaluated the efficacy of amikacin in preventing platelet aggregation in EDTA‐containing feline blood samples and investigated the possible effects on hematologic measurands.Materials and methodsBlood samples (1.0 mL) collected from 100 healthy cats were stored in two EDTA tubes: 0.5 mL in a microtube containing 10 μL of 250 mg/mL amikacin (EDTA‐AMK group) and 0.5 mL in a microtube containing only K2 EDTA 10% (EDTA group). A CBC was executed with an automated impedance blood analyzer, and a microscopic examination of the blood smears was performed.ResultsPlatelet clumps were observed in 56% of samples from the EDTA group and 5% of samples from the EDTA‐AMK group. Platelet counts (PLT), plateletcrit (PCT), and WBC counts were significantly higher (P < .001) in the EDTA‐AMK group compared withi the EDTA group.ConclusionsAmikacin prevents platelet aggregation in feline venous blood samples and does not cause clinically relevant changes in other hematologic measurands. To our knowledge, this is the first report showing the use of amikacin in preventing platelet aggregation in feline blood samples. Based on this study, amikacin could be added to EDTA collection tubes for complete blood counts in cats.
Presumptive renal tubular acidosis secondary to topiramate administration in a cat
Authors: Centola Steven J. , Kaiman Gregory , Rizzo Kaila , Buriko Yekaterina , Burke Jasper 
Published: February 2022

AbstractObjectiveTo describe renal tubular acidosis (RTA) and secondary acquired hyperaldosteronism in a cat as an adverse effect of topiramate therapy.Case SummaryAn 8‐year‐old neutered female cat on chronic oral topiramate therapy at a recommended dose (11.9 mg/kg q 8 h) for seizure control was presented with severe metabolic acidosis and hypokalemia. Plasma electrolyte and acid–base analysis identified a severe metabolic acidosis (pH 7.153, reference interval: 7.31–7.46), hypokalemia (2.08 mmol/L [2.08 mEq/L], reference interval: 3.5–4.8 mmol/L [3.5–4.8 mEq/L]), and ionized hypercalcemia (1.85 mmol/L [1.85 mEq/L], reference range: 1.1–1.4 mmol/L [1.1–1.4 mEq/L]). Urinalysis revealed a urine specific gravity of 1.021 and a pH of 7.0. Diagnostic workup suggested distal RTA as a cause of the cat's acid–base and electrolyte disturbances. Aldosterone concentration was moderately increased, suggestive of secondary hyperaldosteronism. The metabolic abnormalities resolved with supportive care and discontinuation of topiramate.New or Unique Information ProvidedTopiramate is suggested to have led to the development severe RTA in a cat.
Short‐ and long‐term survival after adrenalectomy in 53 dogs with pheochromocytomas with or without alpha‐blocker therapy
Authors: Enright Dory , Dickerson Vanna M. , Grimes Janet A. , Townsend Sarah , Thieman Mankin Kelley M. 
Published: February 2022

AbstractObjectiveTo report data related to the short‐ and long‐term survival of dogs undergoing adrenalectomy for pheochromocytoma, and to determine the influence of preoperative alpha‐blocker therapy.Study designRetrospective.AnimalsFifty‐three dogs.MethodsMedical records were reviewed for dogs diagnosed with pheochromocytoma and treated with adrenalectomy between 2010 and 2020. Preoperative management, imaging studies, intraoperative cardiovascular instability, complications, and procedural information were recorded. When applicable, duration of survival and cause of death, time to recurrence or metastasis, and postoperative complications were recorded.ResultsDuring anesthesia, a hypertensive episode was documented in 46/53 dogs and arrhythmias were recorded in 16/53 dogs. Of these, 37/46 hypertensive dogs and 11/16 dogs with arrhythmias were treated with an alpha‐blocker before surgery. Intraoperative systolic blood pressures reached higher levels by a magnitude of nearly 20% in dogs that were treated preoperatively with an alpha‐blocker (P = .01). All dogs survived surgery and 44 survived to discharge. Follow up ranged from 6 to 1653 days (median 450 days). Median survival time for dogs discharged from the hospital was 1169 days (3.2 years). Recurrence and metastasis were suspected in 3 and 8 dogs, respectively.ConclusionMost dogs survived the immediate postoperative period and achieved long‐term survival with a low reported incidence of tumor recurrence or metastasis. Preoperative alpha‐blocker therapy was not associated with increased survival.Clinical significanceThe favorable outcomes reported in this study should be taken into consideration when discussing treatment options for dogs with pheochromocytomas. This study provides no evidence to support preoperative alpha‐blocker therapy.
Cost of remote patient monitoring for cardiovascular disease: a systematic review protocol
Authors: Zhang Yunxi , Pena Maria T. , Fletcher Lauren M. , Swint John M. , Reneker Jennifer C. 
Published: February 2022

ABSTRACT

Objective:
This review aims to evaluate the costs and cost-effectiveness of remote patient monitoring for cardiovascular disease in the United States.

Introduction:
Cardiovascular disease is a leading public health concern in the United States, resulting in a substantial economic burden. Remote patient monitoring has emerged as a viable and valuable care delivery method to improve cardiovascular disease management at home. However, there is limited systematic research of the cost and cost-effectiveness of using remote patient monitoring to manage the disease.

Inclusion criteria:
This review will consider all studies evaluating the cost of remote patient monitoring for cardiovascular disease management in the United States. The population of interest includes all individuals with various types of chronic cardiovascular disease in the United States.

Methods:
The search strategy will locate both published and unpublished studies. Systematic searches will be completed in PubMed, Embase, Web of Science, CINAHL, Scopus, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, National Health Service Economic Evaluation Database, and the Cost-Effectiveness Analysis Registry. Two reviewers will independently screen titles and abstracts, followed by a full-text review against the inclusion criteria. Disagreements will be resolved through discussion between all study members. The JBI checklist for economic evaluations will be utilized to evaluate the methodological quality of studies. Data will be extracted using a modified version of the JBI data extraction form for economic evaluations. Reviewers will summarize studies and cost-related metrics. The Dominance Ranking Matrix will be used to synthesize full economic evaluation.

Systematic review registration number:
PROSPERO CRD42021270621
OBTAINING RECOMBINANT EXTRACELLULAR FRAGMENTS OF GPR161 RECEPTOR
Authors: Kanaev D.B. , Mukanov K.K. , Adish Zh. , Tokhtarova L. , Zhumabekova S. , Inirbay B. , Tursunov K.A. , Ramankulov Ye.M. , Mukantayev K.N. 
Published: February 2022

The GPR161 is a receptor of the GPCR family and identified as a prognostic biomarker for triple negative breast cancer (TNBC). TNBC characterized by lack of expression of the estrogen receptor (ER), progesterone receptor (PR) and epidermal growth factor receptor (Her2), early recurrence and poor prognosis. The GPR161 is an important regulator of the proliferation and migration of cancer cells. However, anti-GPCR receptor drugs are rarely used in the treatment of cancer, despite evidence of receptor involvement in various aspects of cancer development. Upon receipt of monoclonal antibodies, the success of the study is associated with the presence in sufficient quantities of pure antigen preparations. Recently, gene synthesis under de novo conditions has become a powerful tool in biotechnology. A number of methods have been described, representing thermodynamic balanced methods based on polymerase chain reaction (PCR). This paper presents the results of gene synthesis and the preparation of a recombinant extracellular fragment of the receptor.
To obtain a recombinant protein, an area located outside the cell membrane between the 4th and 5th helix of the receptor was selected. A genetic construct based on the pET32 vector carrying the extracellular fragment of the human GPR161 receptor has been developed and obtained. Strain Escherichia coli BL21/pET32/TM4-5GPR161 producing recombinant extracellular fragment rTM4-5 GPR161 was obtained. The conditions for the isolation and purification of recombinant protein were determined, and its immunogenic properties were studied.
Purified recombinant protein TM4-5GPR161 in its immunological characteristics suitable for the production of strains of hybrid cells producing monoclonal antibodies to the GPR161 receptor.
DIAGNOSIS OF POTATO VIRUSES IN KAZAKHSTAN: MOLECULAR CHARACTERISATION OF ISOLATES
Authors: Karpova O.V. , Alexandrova A.M. , Nargilova R.M. , Kryldakov R.V. , Yekaterinskaya E.M. , Romadanova N.V. , Kushnarenko S.V. , Iskakov B.K. 
Published: February 2022

Virus infection is one of the reasons for the low potato yield in Kazakhstan. The combination of modern methods of germplasm improvement and effective virus diagnosis are the most successful measures to overcome potato viruses. Using ELISA and multiplex RT-PCR methods, potato leaf samples from the Almaty and Kostanay regions of Kazakhstan were analysed for the presence of the carlaviruses potato virus M and potato virus S, the potyvirus potato virus Y, the potexvirus potato virus X, and the polerovirus potato leaf roll virus (PVM, PVS, PVY, PVX, and PLRV, respectively). The potato virus spectrum has changed over the last twenty years, and presently carlavirusеs represent the most widespread genus. Of the leaf samples tested, 84.3% and 46.6% were infected by PVM and PVS, respectively, and co-infection by both viruses occurred. Multiplex RT-PCR assays were developed to detect the five potato viruses, and for two strains of PVS. Based on sequence analyses of the central region of the capsid protein, fourteen Kazakh PVS isolates were identified, of which eleven were classified as the ‘ordinary’ strain, and three as ‘Andean’ strains. Our findings confirmed the existence of divergent PVS strains with different origins present in Kazakhstan.
OBTAINING STRAIN-PRODUCER OF RECOMBINANT HEXON OF BOVINE ADENOVIRUS TYPE 3
Authors: Mukantayev K.N. , Tursunov K.A. , Kanayev D.B. , Tokhtarova L. , Ramankulov Ye. M. , Mukanov K. K. 
Published: February 2022

The diagnosis of bovine adenovirus is difficult due to a large number and identity of clinical symptoms with various diseases. For the diagnosis of adenoviral infection using various methods such as the isolation of the virus, in situ hybridization, enzyme-linked immunosorbent assay (ELISA), immunofluorescence, restriction analysis and polymerase chain reaction (PCR). The methods used are time consuming and require expensive equipment. In this regard, obtaining recombinant virus antigens of diagnostic importance is very important. One of the important diagnostic antigens is hexon, a group-specific protein that induces the formation of group-specific antibodies.
Under de novo conditions, the gene of the N-terminal fragment of hexon of BAV-3 with a length 503 base pairs was synthesized. A strain of E. coli BL21/pET28/rhAdv3 producing recombinant hexon of BAV-3 (rhAdv3) was obtained. The protein produced by the strain BL21/pET28/rhAdv3 contains a hexa-histidine tag and has a molecular weight of 25 kDa. An analysis of the MS/MS data using the Mascot program and the SwissProt database showed that the highest rate (Score 2033) corresponded to a fragment of hexon of BAV-3.
The gene of the fragment of the N-terminal part of the hexon of BAV-3 was synthesized. The genetic construct pET28/rhAdv3 and the microorganism strain BL21/pET28/rhAdv3 producing rhAdv3 protein were obtained. rhAdv3 has the potential to develop test systems designed to diagnose adenoviral infection of farm animals.
BORRELIOSIS: A HIDDEN THREAT FOR KAZAKHSTAN
Authors: Bissenbay A.O. , Zhigailov A.V. , Maltseva E.R. , Egemberdieva R.A. , Skiba Y.A. , Mamadaliyev S.M. 
Published: February 2022

Tick-borne borreliosis, commonly known as Lyme disease or Lyme borreliosis, is a natural focal zoonotic transmissive disease caused by the Borreliella burgdorferi sensu lato complex. If left untreated, the disease can cause damage to the nervous system, joints, or skin, as well as lead to development of chronic atrophic diseases. Diagnosis of borreliosis remains a challenge owing to variations in clinical symptoms and manifestations, simultaneous damage to several organs, and frequent latent persistence of the pathogen in the body, leading to misdiagnosis or late diagnosis. This situation results in defects or delays in the provision of medical care with a high frequency of residual consequences, resulting in temporary disability for the patient that imposes a significant social-economic burden. Ticks of the genus Ixodes are the main carrier of the disease, which inhabit the mountain regions of eastern and southeastern Kazakhstan. However, the distribution area of these ticks has been expanding in recent years owing to the effects of climate change, resulting in an increase of natural foci of tick-borne borreliosis. We here provide updated data on the epidemiology, etiology, pathogenesis, and diagnostic methods for Lyme borreliosis, along with an overview of modern molecular methods for the analysis of borrelia. Moreover, we offer an overall assessment of the risks associated with this disease for Kazakhstan.
A Century of ASME Steam Tables
Authors: Harvey Allan H. , Bellows James C. 
Published: February 2022

Abstract
ASME began working on developing its steam tables, which list standardized thermodynamic properties for water in its vapor, liquid, and supercritical states, at a meeting in Cambridge, Mass., on June 23, 1921. It took decades of building consensus before the first ASME Steam Tables could be published. Today, steam tables are so ubiquitous that most engineers take them for granted.
An Extended Reynolds Equation for Non-Newtonian Lubrication With the Upper Convected Maxwell Model
Authors: Grigor’ev Boris , Eliseev Artem 
Published: February 2022

Abstract
The upper convected Maxwell (UCM) model is one of the ways to describe lubricant’s viscoelasticity. In this paper, a new modified Reynolds equation for the UCM model is derived. This equation may be called extended as compared to its analogs because it incorporates the complete structure of the upper convected derivative without the explicit omitting of any term or using the perturbation technique. Then, a numerical scheme for solving the viscoelastic lubrication problems with the employment of the derived equation is described. A mixed Euler–Lagrange approach is used here: the constitutive rheological equations are resolved by a semi-Lagrangian technique and the extended Reynolds equation is discretized by the finite volume method. A constant surface slope problem is considered as a test case. Excellent agreement is achieved between the numerical solution at low Deborah number and one of the approximate solutions. The results of simulations with different types of time derivative used in Maxwell model both for two- and three-dimensional cases are also discussed.
The Viscoelastic Solution to Geertsma’s Subsidence Problem
Authors: Su Xing , Mehrabian Amin 
Published: February 2022

Abstract
This paper presents the viscoelastic analytical solution for stress and displacement due to prescribed time-varying changes in the pore fluid pressure of a disk-shaped inclusion embedded within a semi-infinite, viscoelastic medium. The correspondence principle of viscoelasticity, along with Hankel–Fourier and Laplace transforms, is used to derive the solution. The instantaneous viscoelastic solution, corresponding to the response immediately after the inclusion pore pressure change, recovers the elastic solution to the same problem (Geertsma 1973). Results are presented for fractional Maxwell and Burgers models of viscoelasticity after being applied to a set of experimental data from creep tests on shale. Solution results are demonstrated and discussed for the cases of constant inclusion depletion, as well as delayed injection of fluid into a previously depleted inclusion.
Nondestructive Surface Profiling and Inspection by Using a Single Unit Magneto-Eddy-Current Sensor
Authors: Kim Jungsub , Chun Heebum , Lee ChaBum 
Published: February 2022

Abstract
This paper presents a novel nondestructive testing system, magneto-eddy-current sensor (MECS), to enable surface profiling of dissimilar materials by combining magnetic sensing for ferromagnetic materials and eddy-current sensing for nonferromagnetic materials. The interactions between an electromagnetic field and nonferromagnetic surface and between a magnetic field and ferromagnetic surface were measured by the MECS. The MECS consists of a conic neodymium magnet and a copper coil wound around the magnet. Aluminum and steel surfaces bonded together were prepared to test nondestructive surface profiling of dissimilar materials by the MECS. The interactions between an electromagnetic field and aluminum surface were characterized by monitoring the impedance of the coil, and the interactions between a magnetic field and steel surface were characterized by using a force sensor attached to the neodymium magnet. The magnetic and electromagnetic effects were numerically analyzed by the finite element model. The developed MECS showed the following performance: measurement spot size 5 mm and 10 mm, dynamic measurement bandwidth (eddy-current sensing 1 kHz and magnetic sensing 200 Hz), measuring range 25 mm and 17 mm, polynomial fitting error 0.51% and 0.50%, and resolution 0.655 µm and 0.782 µm for nonferromagnetic and ferromagnetic surface profiling, respectively. This technique was also applied to surface profiling and inspection of the rivet joining sheet materials. The results showed that the MECS is capable of nondestructively monitoring and determining the riveting quality in a fast, large-area, low-cost, convenient manner.