bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study of effect of alcohol consumption on cardiovascular biomarkers in a tertiary care centre in the Kumaon Region
Authors: Singh Sangeeta , Shukla Devi Prasad , Joshi Basant , Kumar Ashok 
Published: November 2022

An important mechanism responsible for increased cardiovascular risks in chronic excessive alcohol use is the pro-oxidant effects of alcohol. There are some emerging risk factors like :- (i) lipoprotein(a) {Lp[a]}, (ii) High‑sensitivity C‑reactive protein (hs‑CRP), (iii) Lipid profile, (iv) Prothrombotic and proinflammatory factors that play an important role in the pathogenesis of atherosclerosis. So we investigated the relation between the levels of cardiovascular biomarkers & the degree of alcohol intake in alcoholic subjects. The present study was carried out in the Department of Biochemistry, in association with the Department of Medicine, Government Medical College, Haldwani. Estimation of Serum Level of hs-CRP & Lp (a) byturbidimetric immunoassay. Serum Cholesterol by CHOD-POD & Triglycerides by enzymatic colorimetric method. LDL cholesterol was calculated by Friedwald equation.The mean total cholesterol, TG, LDLc, hs-CRP, Lp(a) & including HDLc levels were significantly raised (p &#60; 0.05) in cases as compared to controls. The mean serum total cholesterol & Lp (a) levels showed no significant association across different alcohol drinking groups (p&#62;0.05). The mean TG & LDLc levels were significantly (p&#60;0.05) higher in occasional drinkers and heavy drinkers than that of low-moderate & moderate drinkers. The mean serum HDL cholesterol levels in the occasional drinkers were significantly elevated in comparison to the low-moderate drinkers, moderate drinkers and heavy drinkers. The mean serum hs-CRP level in the mediocre and heavy drinkers was significantly low (p&#60;0.05) as compared occasional drinkers and low-moderate drinkers. Our study suggests heavy drinking (&#62;30drinks/week) must be strongly discouraged as it may lead to changes in cardiovascular markers and dyslipidemia. Our study also showed a beneficial effect of occasional drinking on HDLc and moderate drinking on hs-CRP.
Clinical and socio-demographic profile, drug sensitivity pattern and treatment outcome of drug resistant DR TB patients registered for treatment at a tertiary care centre in South India
Authors: Kallarakal John Sonia , Cency B 
Published: November 2022

Drug resistant tuberculosis is a major threat to TB elimination activities. In our study, we address the clinical, socio-demographic profile, drug sensitivity pattern and treatment outcome of drug resistant TB patients.A record based cross sectional study was conducted in 77 Drug Resistant TB cases registered for standardized treatment at a tertiary care centre in South India from January 2012 to December 2019. The clinical, socio-demographic, radiological characteristics, drug sensitivity pattern and treatment outcome of these patients were recorded. 51 were males and 26 were females. 31 (40.3%) were diabetic, 30 (39%) were tobacco users, 12 (15.6%) were health care workers, 40 (52%) had low BMI and 4 (5.2%) were HIV-TB. 66 (85.7%) showed resistance to isoniazid, 62 (80.5%) to rifampicin, 8 (10.4%) to ethambutol, 9 (11.7%) to Fluoroquinolones, 2 (2.6%) to Second Line Injectables and 6 (7.8%) to Streptomycin. Treatment outcomes were as follows: cured 41 (61%), treatment completed 2 (2.6%), failure 2 (2.6%), lost to follow up 9 (11.7%), regimen changed 3 (3.9%), died 11 (14.3%), not evaluated 2 (2.6%) and treatment stopped due to adverse drug reactions 1 (1.3%). Unfavourable treatment outcomes were associated with low BMI, previous ATT and fluoroquinolone resistance.More than half of the patients had favourable treatment outcomes. Low BMI, previous ATT and fluoroquinolone resistance were factors associated with poor outcomes.
Człowiek w przestrzeni medialnej w kontekście fali sinusoidalnej
Authors: Jęczeń Jarosław 
Published: November 2022

Zasadniczo nauki humanistyczne różnią się od przyrodniczych tym, że przedmiotu ich badań nie można ująć w sposób matematyczny. W dobie cyfryzacji ta granica nie jest już tak sztywna, tym bardziej kiedy przedmiotem badań niniejszego artykułu są proporcje między bezpośrednią interaktywną komunikacją interpersonalną (face to face) a interaktywną komunikacją pośrednią za pomocą nowoczesnych technologii komunikacyjnych (online) oraz ich wpływ na człowieka i rodzinę we współczesnej przestrzeni medialnej. Matematyka, pomimo swego zamkniętego charakteru, wyznacza nowe kierunki myślenia, gwarantując przy tym pewną logiczność, a następnie możliwość weryfikacji za pomocą badań, jak ma to miejsce np. w socjologii. Punktem wyjścia, a jednocześnie podstawą do sformułowania wniosków i odpowiedzi na postawione pytanie badawcze jest w tym artykule matematyczna fala sinusoidalna. Umożliwia ona spojrzenie na człowieka w przestrzeni medialnej ostatnich dekad i w dobie COVID 19 oraz pozwala sformułować postulaty na przyszłość.
Peningkatan Kinerja Pengelolaan Kelas Guru PAI Melalui Supervisi Klinis di Sekoah Binaan
Authors: _Sukman Sukman 
Published: November 2022

Dalam menjalankan tugas sebagai supervisor, pengawas sekolah dapat memilih pendekatan yang tepat sesuai dengan masalah yang dihadapi guru. Supervisi tidak didefinisikan secara sempit sebagai satu cara terbaik untuk diterapkan di segala situasi melainkan perlu memperhatikan kemampuan individu, kebutuhan, minat, tingkat kematangan individu, karakteristik personal guru, semua itu dipertimbangkan untuk menerapkan supervisi. Berdasarkan latar belakang masalah yang diuraikan di atas, pokok masalah dalam penelitian ini dapat dirumuskan seperti tertuang pada pertanyaan berikut “apakah pelaksanaan kegiatan supervisi klinis dapat meningkatkan kemampuan guru pendidikan agama Islam dalam pengelolaan kelas”. Adapun tujuannya adalah untuk meningkatkan kemampuan, pemahaman, dan mengembangkan strategi pengelolaan kelas bagi guru-guru pendidikan agama Islam di Sekolah Binaan . Subjek penelitian adalah guru PAI di Sekolah Binaan sebanyak guru. Teknik pengumpulan data melalui teknik observasi, dan teknik dokumentasi. Adapun analisis data secara deskriptif kualitatif dalam penelitian ini adalah memaknai data dengan cara membandingkan hasil dari sebelum dilakukan tindakan dan sesudah tindakan. Analisis data ini dilakukan pada saat tahapan refleksi. Hasil analisis digunakan sebagai bahan refleksi untuk melakukan perencanaan lanjut dalam siklus selanjutnya. Hasil analisis data menunjukkan bahwa pada kondisi awal hanya mencapai angka rerata 55,67 dengan kriteria rendah, meningkat menjadi 76,33 dengan kriteria cukup, dan pada siklus terakhir menjadi 91,50 dengan kriteria sangat baik, dan secara individual per guru pada kondisi awal belum ada guru Pendidikan Agama Islam yang dinyatakan tuntas, meningkat menjadi 2 guru atau 40,00% dan pada siklus terakhir menjadi 5 orang guru atau 100%. Dari penjelasan di atas maka dapat disimpulkan bahwa pelaksanaan supervisi klinis terbukti dapat meningkatkan kinerja guru pendidikan agama Islam dalam pengelolaan kelas di Sekolah Binaan Tahun Pelajaran 2017/2018.
Pengaruh Faktor Maternal Ibu terhadap Kejadian Stunting pada Balita Usia 24-59 Bulan di Wilayah kerja UPT Puskesmas Sopaah Kabupaten Pamekasan
Authors: Wardani Dewi Kusuma 
Published: November 2022

Background: The incidence of stunting still being a major nutritional problem for toddlers around the world. Stunting occurs due to various factors that hinder the baby's growth process during first 1000 days of life or from the time the baby is in the womb until he is 24 months after birth, but the occurrence is only seen after the toddler is 24 months old. Stunting has a short-term impact in the form of disturbances in cognitive development and long-term effects that can be permanent.Objectives: The purpose of this study was to analyze the influence of maternal factors on the incidence of stunting in toddlers among 24-59 months in the Working Area of Sopaah Primary Health Care on 2021.Methods: This type of research was observational analytic with a case control research design. The research sample was 54 consisting of 27 case samples and 27 control samples. The data used are primary data obtained from interviews with respondents and secondary data sourced from the respondent's MCH Handbook. Analysis of research data using the SPSS program to perform statistical tests of chi-square and Odds Ratio.Results: The results of this study indicate that there is a significant effect between maternal height during pregnancy (p-value = 0.000 ; OR = 16.000) and Hypertension (p-value = 0.021; OR = 4.086) with the incidence of stunting in toddlers among 24-59 months in Indonesia. The Working Area of the Sopaah Primary Health Care. Meanwhile, maternal age during pregnancy (p-value = 1,000) and interval of pregnancy (p-value = 0.776) had no effect on the incidence of stunting in toddlers among 24-59 months.Conclusions: the prevalence of stunting in the Work Area of the Sopaah Primary Health Care on 2021 has increased compared to 2019 and the maternal factors that influence the incidence of stunting in toddlers are maternal height and hypertension, while maternal age and interval of preganancy do not have a significant influenceKeywords: stunting, maternal height, maternal age, interval of pregnancy, hypertension
Faktor-Faktor yang Berhubungan dengan Kejadian Bayi Berat Lahir Rendah (BBLR) di Indonesia Berdasarkan Analisa Data Sekunder SDKI Tahun 2017
Authors: Yuwana Noki Rieke Diah Ayu , Mahmudiono Trias , Rifqi Mahmud Aditya 
Published: November 2022

Latar Belakang: Bayi Berat Lahir Rendah (BBLR) merupakan penyebab utama angka kematian neonatal di Indonesia yang tergolong tinggi yaitu 15/1000 kelahiran hidup. Beberapa provinsi di Indonesia belum memenuhi target nasional untuk BBLR yang didominasi oleh provinsi dengan mayoritas wilayah perdesaan. Kejadian BBLR berhubungan dengan banyak faktor risiko baik dari karakteristik ibu, bayi dan sosio-demografi.Tujuan: Penelitian ini bertujuan untuk mengetahui faktor risiko yang berhubungan dengan BBLR di Indonesia.Metode: Penelitian menggunakan desain studi cross-sectional dengan data Survei Demografi dan Kesehatan Indonesia (SDKI) Tahun 2017. Jumlah responden yaitu 13.473 wanita berusia 15-49 tahun yang melahirkan dalam 5 tahun sebelum survei dan memenuhi semua variabel penelitian. Analisis yang dilakukan meliputi analisis deskriptif untuk menggambarkan karakteristik responden serta uji regresi logistik dan chi-square untuk menentukan faktor yang berhubungan secara signifikan dengan kejadian BBLR.Hasil: Hasil penelitian menunjukkan faktor yang berhubungan dengan kejadian BBLR yaitu pendidikan ibu (OR=1,3; 95%CI=1,16-1,53; p<0,01), frekuensi kunjungan antenatal/K4 (OR=1,59; 95%CI=1,25-2,02;p<0,01) dan tempat tinggal (OR=0,86; 95%CI=0,75-0,99;p=0,03). Akan tetapi hasil tidak menunjukkan hubungan yang signifikan antara usia ibu, paritas, jarak kehamilan, jenis kelamin bayi, pekerjaan ibu dan kunjungan antenatal pertama/K1.Kesimpulan: Pendidikan ibu, K4 dan tempat tinggal berhubungan dengan kejadian BBLR di Indonesia sehingga diperlukan program untuk memperbaiki pelayanan antenatal terutama pada ibu yang tergolong pendidikan rendah pada wilayah pedesaan.
Literature Review: Overview of Heavy Metal Contamination of Shrimp in Indonesia
Authors: Milati Zida Sinata 
Published: November 2022

ABSTRAK

Latar Belakang : Udang merupakan salah satu sumber protein hewani yang bergizi dan memiliki banyak manfaat bagi tubuh. Produksi udang di Indonesia menjadi salah satu dari 10 penghasil udang utama dunia, hal ini sejalan dengan meningkatnya konsumsi ikan, utamanya udang pada masyarakat Indonesia. Udang yang hidup di air tawar maupun di air laut selalu mencari makan di dasar air yakni pada sedimen, yang mana banyak terendap partikel-partikel padatan berupa pasir dan lumpur serta logam berat sebagai akibat proses pengendapan di perairan, sehingga udang merupakan indikator yang baik untuk polusi logam berat.
Tujuan : Tujuan penulisan literatur review ini adalah untuk menggambarkan kondisi cemaran logam berat pada udang di Indonesia. Oleh karena itu, perlu dilakukan pemantauan konsentrasi cemaran logam berat pada udang, sehingga dapat memberikan sinyal peringatan kepada masyarakat apabila kadarnya melebihi ambang batas (Zodape, 2014).
Metode : Metode yang digunakan dalam penulisan artikel ini adalah Literatur Review yaitu penelitian dengan melakukan telaah terhadap beberapa artikel nasional maupun internasional. Database yang digunakan berasal dari Google Scholar dengan menggunakan kata kunci terkait dan didapatkan 2160 artikel, setelah dilakukan screening topik dan kriteria inklusi yang telah ditetapkan, didapatkan 13 artikel yang selanjutnya dilakukan Literatur Review.
Ulasan : Uji kandungan logam berat (Hg, Pb, Cu, Cr, As, Mn, dan Zn) pada udang di beberapa wilayah di Indonesia baik menggunakan metode uji AAS (Atomic Absorption Spectrophotometer) maupun uji warna (Rapid Test Kits) menghasilkan beberapa variasi, untuk sampel udang yang diuji kandungan cemaran logam berat Hg, Cu, Mn, dan Zn pada semua sampel aman, sedangkan sampel udang yang diuji kandungan Pb, Cd, dan Cr terdapat hasil positif dan negatif (perbandingan 1 : 2).
Kesimpulan : Terdapat variasi hasil kandungan logam berat (Hg, Pb, Cd, Mn, Cu, As, dan Zn) pada sampel udang dengan di beberapa wilayah di Indonesia. Sampel udang yang positif maupun negatif logam berat tertentu, dapat dipengaruhi oleh beberapa faktor. Masyarakat dihimbau tetap terus berhati-hati yakni dengan selalu mengolah udang sebelum dikonsumsi dengan baik dan benar.

Kata Kunci : Cemaran, Logam Berat, dan Udang
Workshop Pelatihan Learning Management System (LMS) Untuk Peningkatan Kualitas Pembelajaran Jarak Jauh Di SMP Negeri 242 Jakarta
Authors: Hidayaht Achmad Nur , Kurniawan Nandi , Istiqomah Nurul 
Published: November 2022

This community service activity is to provide training in designing online learning through the use of the Edmodo online platform for teachers of SMP Negeri 242 Jakarta. This is due to the Covid-19 pandemic which requires learning activities to be carried out from home (PJJ). The ability of teachers to utilize digital learning platforms by moving offline learning to online learning, as well as organizing student assignments into competencies that must be mastered and improved in order to create synchronous and asynchronous learning. The application of Edmodo is a learning alternative that creates effective learning to support the process of organizing learning activities because Edmodo has several features, such as "Assignment", "Quiz", and "Poll" and several other features such as cloud for material storage.
This training activity was attended by 26 teachers of SMP Negeri 242 Jakarta from various subject teachers. The training is carried out online and offline. The data acquisition instrument used a questionnaire which was used to determine the initial perceptions and insights of the training participants towards the BDR learning that had been carried out and to find out their perceptions and insights after attending the training. Based on the results of the questionnaire, the training that has been carried out has had a positive and beneficial impact on the teachers of SMP Negeri 242 Jakarta.
A novel mineral composition increases soybean crop yield by mitigating stress induced by ultraviolet-A and -B radiation
Authors: Abreu André L. , Gratão Priscila L. , Rodriguez Carlos A.V. , Junior Gilmar S. Sousa 
Published: November 2022

Abstract
Ultraviolet radiation (UVR) is an important environmental abiotic stress that affects the yield potential of agricultural crops, and few practical solutions are available for protecting large-scale field cultivation. The present study assessed the protective effect of a novel mineral composition principally based upon microparticles of crystal and insoluble quartz sand applied over the top of plants to mitigate the stress effects of UV-A or UV-B radiation. Soybean (Glycine max (L.) Merrill) plants were cultivated under three alternative UVR exposure scenarios (no UV, +UV-A, +UV-B) to compare treated and untreated plants with that composition. Measurements of malondialdehyde (MDA) and proline contents demonstrated the effects of +UV-A and +UV-B on plants and the effectiveness of the foliar treatment in mitigating such stress. Biometric assessment showed that root weight, foliar biomass, and number of pods of untreated plants were negatively impacted by both +UV-A and +UV-B, whereas in treated plants, the damages for both +UV-A and +UV-B were almost entirely mitigated. The results of this study endorse the use of a promising tool for growers to achieve sustainable yield in soybeans and potentially other field crops in the face of increasing challenges due to climate change.
Non-lactational Breast Abscess due to Burkholderia Contaminans – Case Report of a Rare Organism with Rare Presentation
Authors: Pal Bishal , Dutta Souradeep , Jain Ankit , Anandhi Amaranathan 
Published: November 2022

Abstract
Introduction:
A breast abscess (BA) is a localized collection of purulent materials within breast tissues. BA are most frequently present during the lactational period, but they can rarely manifest in the non-lactational period. Staphylococcus aureus is the most common causative organism, mostly methicillin-resistant S. aureus, followed by coagulase-negative Staphylococci. Burkholderia contaminans is an uncommon opportunistic infection commonly associated with cystic fibrosis. BA due to a Burkholderia contaminans infection has never been reported previously.
Case Presentation:
We are reporting a 25-year-old immunocompetent woman with a non-lactational left BA caused by Burkholderia contaminans. She complaints of gradually progressive lump in her left breast for one year. Local examination revealed a tender swelling with induration and soft central region in the lower inner and outer quadrant suggestive of BA with palpable left axillary lymph node. She was successfully treated with ultrasound-guided needle aspiration followed by a course of culture-based antibiotics.
Conclusions:
Burkholderia contaminans is one of the 24 species in the Burkholderia cepacia complex (Bcc). Burkholderia contaminans is an extremely rare opportunistic pathogen with low virulence but extensive virulence factors. Bcc infection can vary from an asymptomatic carrier, chronic infection ranging from pulmonary involvement to invasive Bcc, and life-threatening presentation like cepacia syndrome, especially in CF and chronic granulomatous disease patients. In our patient symptoms of BA was chronic with recent aggravation. BA should be managed by incision and drainage or image guided needle aspiration, undercover of enteral or parenteral antibiotics depending upon severity of the disease.
Analysis of Genetic Diversity in Patients with Major Psychiatric Disorders versus Healthy Controls:
A molecular-genetic study of 1,698 subjects genotyped for 100 candidate genes (549 SNPs)
Authors: Stassen Hans , Bachmann Silke , Bridler René , Cattapan Katja , Hartmann Annette , Rujescu Dan , Seifritz Erich , Weisbrod Matthias , Scharfetter Christian 
Published: November 2022

Abstract
In this study we addressed the question of the extent to which irregularities in genetic diversity might separate patients with major psychiatric disorders from healthy controls.
Genetic diversity was quantified per gene through multidimensional “gene vectors” assembled from 4-8 polymorphic SNPs located within each of 100 candidate genes. The number of different genotypic patterns observed per gene was called the gene’s “diversity index”. Our sample was comprised of 1,698 subjects from Central Europe (1,431 psychiatric patients, 267 healthy controls), all genotyped for 549 specifically selected SNPs.

The evaluation of the diversity indices of the 100 candidate genes resulted in a mean value of 109.4±82.8, ranging from 18 to 476. Highly significant deviations from “normal” diversity values were detected for (1) major depression (n=596): a significant reduction (p<0.0001); (2) Alzheimer’s disease (n=75): a significant reduction (p<0.0001); and (3) schizoaffective disorders (n=64): a significant increase (p<0.0001). Almost one third of the genes were correlated with each other, with correlations ranging from 0.0303 to 0.7245.

The central finding of this study was the discovery of “singular genes” characterized by distinctive genotypic patterns that appeared exclusively in patients but not in healthy controls. In each of the diagnostic subgroups under study, there were no less than 45%-55% of patients who exhibited genotypic patterns of singular genes that did not at all show up in the healthy controls. Neural Net (NN) analyses enabled the construction of nonlinear classifiers that correctly identified up to 90% of patients in comparisons with healthy controls at false-positive error rates of zero percent. The NN analyses revealed considerable overlaps on the genotype level between the various clinically defined diagnostic subgroups, suggesting that diagnosis-crossing, unspecific vulnerabilities are likely involved in the pathogenesis of major psychiatric disorders.

Clinical applications of the proposed method are immediately possible and will facilitate the early detection of latent psychiatric disorders among risk cases, so that early interventions can be started before clinically relevant symptoms develop. A larger number of hospitalizations could be prevented in this way.
Clinical Profile and Outcomes of Congenital Cataracts at a Reference Center in Mexico
Authors: Irusteta Leire , Domene-Hickman Jorge , Zuñiga-Posselt Karla , Ramos-Barrera Emilia , Matiz-Moreno Humberto 
Published: November 2022

Abstract
Background: Congenital cataracts are the most common cause of preventable childhood blindness in the world. Treatment of congenital cataracts is among the most difficult and cost-effective interventions in ophthalmology. Our aim was to review a large cohort of patients under a 10-year period to gain a better understanding of multiple factors that influence the outcome of congenital cataracts.
Methods: Retrospective review of medical charts of all children with diagnosis of cataract between January 2009 and December 2019 conducted at Ophthalmology Institute “Conde de Valenciana”', Mexico City. Exclusion criteria were children with traumatic or metabolic cataracts, cataracts secondary to uveitis, cataracts associated with previous intraocular surgery or steroid use and patients with no surgical or follow up records. All patients underwent simple aspiration of lens material with coaxial irrigation-aspiration system. In some patients, additional anterior vitrectomy and posterior capsulorhexis was performed. In older children (usually > 3 months of age) an IOL was implanted.
Results: A total of 198 eyes of 132 children were analyzed. Median age at presentation was 5.09 years, SE +/- 4.48 years. It was found that the most common cause of congenital cataract was idiopathic 81.81% (N=108), the remaining 18.18% (N=24) was associated with some systemic disease. It was found a 3.5 higher risk of having bilateral cataracts if a systemic disease was present (p=0.01). The most frequent type of congenital cataract was nuclear in 30.1% (N=59), followed by total in 24.5% (N=48) and posterior polar in 14.3 (N=28). A 1.51 higher risk of presenting visual acuity worse than 1.00 LogMar (p=0.011) was found when the form of presentation was total cataracts. 100% of the patients underwent surgery. Only 7.5% (N=15) of the patients required a second surgical intervention. The initial surgical technique was not directly correlated to the requirement for a second surgery (Odds Ratio 0.097, p=0.356).
Conclusion: We present our approach to congenital cataracts; these findings provide suggestions for etiology and epidemiology of congenital cataracts and the factors that influence patient visual prognosis.