bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural features of Dnase1L3 responsible for serum antigen clearance
Authors: McCord Jon J. , Engavale Minal , Masoumzadeh Elahe , Villarreal Johanna , Mapp Britney , Latham Michael P. , Keyel Peter A. , Sutton R. Bryan 
Published: August 2022

AbstractAutoimmunity develops when extracellular DNA released from dying cells is not cleared from serum. While serum DNA is primarily digested by Dnase1 and Dnase1L3, Dnase1 cannot rescue autoimmunity arising from Dnase1L3 deficiencies. Dnase1L3 uniquely degrades antigenic forms of cell-free DNA, including DNA complexed with lipids and proteins. The distinct activity of Dnase1L3 relies on its unique C-terminal Domain (CTD), but the mechanism is unknown. We used multiple biophysical techniques and functional assays to study the interplay between the core catalytic domain and the CTD. While the core domain resembles Dnase1, there are key structural differences between the two enzymes. First, Dnase1L3 is not inhibited by actin due to multiple differences in the actin recognition site. Second, the CTD augments the ability of the core to bind DNA, thereby facilitating the degradation of complexed DNA. Together, these structural insights will inform the development of Dnase1L3-based therapies for autoimmunity.
Development and characterization of a novel alpha particle SOI pixel sensor for neutron detection
Authors: Mendicino R. , Arai Y. , Dalla Betta G-F. , Perenzoni M. , Tosi E. 
Published: August 2022

Abstract
Semiconductor sensors for neutron detection have been initially proposed as direct replacement of 3He detectors but have recently raised interest in imaging systems. We have developed a monolithic sensor with high spatial granularity in SOIPIX technology for the detection of alpha particles of energy compatible with the reaction products of neutrons with typical converter materials. The chipset is composed by the main pixel matrix and the test structures needed for a better understanding of the chip functionality and for studying the electronic tuning strategies. The fabricated prototypes have been recently delivered and the first tests under alpha source have been performed. In this paper we will present the proposed devices and the results of the experimental characterization.
Compression performance and analytical model of hexagonal-core sandwich panels fabricated by 3D printed continuous carbon fiber-reinforced thermosetting epoxy composites
Authors: Xin Zhibo , Ming Yueke , Duan Yugang , Wang Ben , Yang Qiang 
Published: August 2022

Abstract
Composite sandwich structures are widely used in a multitude of fields owing to their excellent properties, such as light weight and high strength. In this study, a series of hexagonal-core sandwich panels were integrally fabricated by three-dimensional (3D) printed continuous fiber reinforced thermosetting epoxy composites. The influence of the scaling effects that is, the side length and layer thickness on the compression performance of these structures was studied. The experimental results showed that the specific strengths of three different hexagonal-core sandwich panels with different side lengths of 5 mm, 10 mm and 20 mm side lengths is roughly maintained at 0.018 MPa/(kg m−3). In addition, doubling the wall thickness of the hexagonal core increases the compressive strength by only 38.9%. The performance characteristics of these hexagonal-core sandwich panels, which change with size, can provide a reference for designers and can be used for the preliminary prediction of the structural strength.
Sustainable approach for reclamation of graphite from spent lithium-ion batteries
Authors: Perumal P , Raj Benjamin , Mohapatra Mamata , Basu Suddhasatwa 
Published: August 2022

Abstract
A scalable and facile regeneration route is utilized to recover the graphite from a spent lithium-ion battery (LIB). Eco-friendly organic acid is employed as a leaching-curing reagent for the present work. All the unwanted content of elements e.g. Ni, Co, Li, Cu and Al has been completely terminated from the graphite after the purification step without any additional calcination process. The optical, structural and electrochemical properties of as-reclaimed graphite have been studied by several analytical methods. Regenerated graphite is restored to its layered crystal structure along with expansion in the interlayer distance, and the same is confirmed from scanning electron microscopy and X-ray diffraction analysis respectively. Notably, high purity graphite is achieved and tested in its electrochemical storage property in supercapacitor (SC) applications. As an outcome, recreated graphite exhibits a maximum areal capacitance of 285 mF cm−2 at 5 mV s−1. The fabricated symmetric SC demonstrates the superior energy storage performance in terms of durability and higher capacitance (131 mF cm−2) with better capacity retention over several cycles. It is worth mentioning that this curing process is a facile route, consumes lower energy and eco-friendly methodology and thereby may have futuristic extent for the bench scale reclamation of graphite from spent LIBs.
Photosymbiotic tissue engineering and regeneration
Authors: Maharjan Sushila , Bonilla-Ruelas Diana Priscills , Orive Gorka , Zhang Yu Shrike 
Published: August 2022

Abstract
As the field of tissue engineering and regenerative medicine progresses, the possibility for artificial organs to restore normal tissue functions seems to become more feasible. However, a major challenge in the long-term culture of the engineered tissues is the lack of adequate oxygenation. The photosynthetic supply of oxygen (O2) for tissues and organs using photoautotrophic microorganisms has been explored recently in both in vitro and in vivo studies. The biofabrication of photosymbiotic scaffolds using biomaterials, photosynthetic microorganisms, and human cells has shown constant generation of O2 in response to light illumination while avoiding hypoxic conditions. This emerging strategy of photosymbiotic oxygenation is potentially an attractive approach to overcome the need of adequate oxygenation in tissue engineering and regenerative medicine. This Perspective aims to present an overview on the applications of photoautotrophic microorganism-enabled oxygenation strategies for overcoming hypoxia-related challenges in tissue engineering and regenerative medicine.
Metagenomic binning with assembly graph embeddings
Authors: Lamurias Andre , Sereika Mantas , Albertsen Mads , Hose Katja , Nielsen Thomas Dyhre 
Published: August 2022

AbstractMotivationDespite recent advancements in sequencing technologies and assembly methods, obtaining high-quality microbial genomes from metagenomic samples is still not a trivial task. Current metagenomic binners do not take full advantage of assembly graphs and are not optimized for long-read assemblies. Deep graph learning algorithms have been proposed in other fields to deal with complex graph data structures. The graph structure generated during the assembly process could be integrated with contig features to obtain better bins with deep learning.ResultsWe propose GraphMB, which uses graph neural networks to incorporate the assembly graph into the binning process. We test GraphMB on long-read datasets of different complexities, and compare the performance with other binners in terms of the number of High Quality (HQ) genome bins obtained. With our approach, we were able to obtain unique bins on all real datasets, and obtain more bins on most datasets. In particular, we obtained on average 17.5% more HQ bins when compared with state-of-the-art binners and 13.7% when aggregating the results of our binner with the others. These results indicate that a deep learning model can integrate contig-specific and graph-structure information to improve metagenomic binning.Availability and implementationGraphMB is available from https://github.com/MicrobialDarkMatter/GraphMB.Supplementary informationSupplementary data are available at Bioinformatics online.
Community reinvestment challenges in the age of gentrification: Pittsburgh, Pennsylvania as a case study for wide bank lending disparities
Authors: Holland Daniel , Squires Gregory D 
Published: August 2022

Abstract
Racially unequal home mortgage loan patterns are alive and well today with many financial institutions. Efforts to change these trends are difficult when few question the ‘reinvestment thesis’—an environment in which financial institutions are assumed to meet community needs, even when data suggest the opposite. In this article, we analyze thirteen years of financial institution lending data from 2007 to 2019 in Pittsburgh that show how the city’s African American neighborhoods are starved for private capital as vastly more loans and loan dollars were approved in white neighborhoods. Conversely, an analysis of public expenditures for affordable housing between 2010 and 2020 demonstrate the majority of government dollars went to minority neighborhoods. These data provide a partial explanation as to why Pittsburgh lost &gt; 10,000 Black residents over the past decade. These wide disparities are a significant barrier to building African American wealth and present challenges to community development efforts.
Device fracture as a potential complication of a left ventricular microaxial pump catheter: a case report
Authors: Mutallimov Mirza , Er Fikret , Gassanov Natig 
Published: August 2022

Abstract

Background
The use of an Impella pump catheter has advanced substantially in the last few years due to the simple insertion procedure and smaller device size. However, its use is still associated with some risks and complications. Here, we report a device fracture as a rare complication that occurred during the device extraction a few days after the initial insertion.

Case summary
A 74-year-old man with cardiogenic shock due to acute non-ST-segment elevation myocardial infarction presented to our hospital, and he was transferred to the cath lab for emergency percutaneous coronary intervention (PCI). An Impella CP pump was inserted without any complication prior to PCI. After successful PCI, the patient was transferred to the intensive care unit with device left for continued haemodynamic support. After 3 days, as the patient’s condition remarkably improved, we tried to remove the device. However, a persistent mechanical resistance hindered the further catheter retraction; therefore, a decision was made to remove the catheter under fluoroscopy. Indeed, the fluoroscopy revealed a broken distal part of the pump at the level of the ascending aorta. The retained catheter tip was eventually snared with a snare catheter and removed without any complication.

Discussion
An Impella microaxial pump may improve the overall outcome by providing haemodynamic support in critically ill patients. However, its application is not without complications. Intravascular device tip fracture, as demonstrated in this case report, is a rarely reported complication. The use of a snare catheter can be an option in retrieving a broken pump.
Pay One or Pay All? The Role of Incentive Schemes in Decision Making Across Adulthood
Authors: Horn Sebastian S , Schaltegger Thierry , Best Ryan , Freund Alexandra M 
Published: August 2022

Abstract

Objectives
This research addresses how younger and older adults’ decisions and evaluations of gains and losses are affected by the way in which monetary incentives are provided. We compared 2 common incentive schemes in decision making: pay one (only a single decision is incentivized) and pay all (incentives across all decisions are accumulated).

Method
Younger adults (18–36 years; n = 147) and older adults (60–89 years; n = 139) participated in either a pay-one or pay-all condition and made binary choices between two-outcome monetary lotteries in gain, loss, and mixed domains. We analyzed participants’ decision quality, risk taking, and psychometric test scores. Computational modeling of cumulative prospect theory served to measure sensitivity to outcomes and probabilities, loss aversion, and choice sensitivity.

Results
Decision quality and risk aversion were higher in the gain than mixed or loss domain, but unaffected by age. Loss aversion was higher, and choice sensitivity was lower in older than younger adults. In the pay-one condition, the value functions were more strongly curved, and choice sensitivity was higher than in the pay-all condition.

Discussion
An opportunity of accumulating incentives has similar portfolio effects on younger and older adults’ decisions. In general, people appear to decide less cautiously in pay-all than pay-one scenarios. The impact of different incentive schemes should be carefully considered in aging and decision research.
Rice EIL1 interacts with OsIAAs to regulate auxin biosynthesis mediated by the tryptophan aminotransferase MHZ10/OsTAR2 during root ethylene responses
Authors: Zhou Yang , Ma Biao , Tao Jian-Jun , Yin Cui-Cui , Hu Yang , Huang Yi-Hua , Wei Wei , Xin Pei-Yong , Chu Jin-Fang , Zhang Wan-Ke , Chen Shou-Yi , Zhang Jin-Song 
Published: August 2022

Abstract
Ethylene plays essential roles in adaptive growth of rice (Oryza sativa). Understanding of the crosstalk between ethylene and auxin (Aux) is limited in rice. Here, from an analysis of the root-specific ethylene-insensitive rice mutant mao hu zi 10 (mhz10), we identified the tryptophan aminotransferase (TAR) MHZ10/OsTAR2, which catalyzes the key step in indole-3-pyruvic acid-dependent Aux biosynthesis. Genetically, OsTAR2 acts downstream of ethylene signaling in root ethylene responses. ETHYLENE INSENSITIVE3 like1 (OsEIL1) directly activated OsTAR2 expression. Surprisingly, ethylene induction of OsTAR2 expression still required the Aux pathway. We also show that Os indole-3-acetic acid (IAA)1/9 and OsIAA21/31 physically interact with OsEIL1 and show promotive and repressive effects on OsEIL1-activated OsTAR2 promoter activity, respectively. These effects likely depend on their EAR motif-mediated histone acetylation/deacetylation modification. The special promoting activity of OsIAA1/9 on OsEIL1 may require both the EAR motifs and the flanking sequences for recruitment of histone acetyltransferase. The repressors OsIAA21/31 exhibit earlier degradation upon ethylene treatment than the activators OsIAA1/9 in a TIR1/AFB-dependent manner, allowing OsEIL1 activation by activators OsIAA1/9 for OsTAR2 expression and signal amplification. This study reveals a positive feedback regulation of ethylene signaling by Aux biosynthesis and highlights the crosstalk between ethylene and Aux pathways at a previously underappreciated level for root growth regulation in rice.
Crow Dog’s Trial and Ledger Drawing: Cultural Production and Tribal Nation in the Maw of the American Empire
Authors: Frank Ross 
Published: August 2022

Abstract
The 1882 trial of Crow Dog (Kangi Súŋka), for the murder in 1881 of Spotted Tail (Siŋté Glešká), a leader of the Sicangu/Brulé Lakota, had all of the hallmarks of a twentieth- or twenty-first-century celebrity trial. People came for miles around Deadwood, Dakota Territory and far-flung parts to the west in order to attend the trial and rub shoulders with the participants. From the point of view of government officials in the Bureau of Indian Affairs who engineered the trial, the goal was to wrest criminal jurisdiction from Indian governments on reservations. A number of drawings on paper, “ledger drawings,” produced by Crow Dog and other Lakota participants engulfed in the trial and related activities, show another colonial process at work—the appropriation and resignification of the Native voice within the public sphere. The confluence of national, regional, and local events swirling around Deadwood, Dakota Territory, and the legal case that becomes Ex-parte Crow Dog before the Supreme Court, resituates the historical significance of this genre of “Captivity Ledgers” both for Lakota and settler sensibilities during the post-Civil War and early reservation era.
False-positive Fentanyl Urine Detection After Initiation of Labetalol Treatment for Hypertension in Pregnancy: A Case Report
Authors: Wanar Amita , Isley Breanna Cassidy , Saia Kelley , Field Thomas A. 
Published: August 2022

Background
Labetalol hydrochloride (LH) is a pharmacologic treatment for hypertensive disease (HD) in pregnancy. However, for pregnant persons with substance use disorders (SUDs), LH may interfere with urine drug testing.

Case Summary
We present 3 pregnant or postpregnant persons with SUDs who experienced presumptive positive urine immunoassays for fentanyl while prescribed LH for perinatal HD.

Discussion
Labetalol hydrochloride treatment for HD in pregnancy can result in presumptive positive urine immunoassays for fentanyl. Unrecognized or misinterpreted, this phenomenon can lead to significant consequences for pregnant and postpartum persons with co-occurring substance use and hypertensive disorders. Clinicians caring for pregnant persons with SUDs must be aware of this phenomenon and its sequelae when ordering and interpreting urine immunoassays for fentanyl.
Factors Associated With the Presence of Co-occurring Pain and Substance Use Disorder Programs in Substance Use Treatment Facilities
Authors: Ramdin Christine , Attaalla Kyrillos , Ghafoor Naila , Nelson Lewis 
Published: August 2022

Objectives
The rise in deaths related to substance use has caused a push toward linking patients to pharmacological maintenance treatment and, when appropriate, to residential substance use treatment facilities. One of the underlying issues in a subset of patients with substance use disorder (SUD) is chronic pain. We evaluated the prevalence and characteristics of those facilities that offer treatment programs tailored for patients with co-occurring pain and SUD.

Methods
This study was a retrospective review of data collected by the National Survey of Substance Abuse Treatment Services in 2019. The National Survey of Substance Abuse Treatment Services is sent annually to all substance use treatment facilities and collects information on their characteristics and services. We calculated prevalence of chronic pain programs, reported characteristics, and did a binomial logistic regression to determine predictors of a facility offering such a program.

Results
Of 15,945 respondents, 2990 (18.8%) of facilities offered a tailored program for patients with co-occurring pain and SUDs. Characteristics that were best predictors included the following: facility has a tailored program for veterans (P < 0.001), serves only clients with opioid use disorder (P = 0.03), and provides maintenance services with methadone or buprenorphine for treating opioid use disorder (P = 0.009).

Conclusion
As of 2019, only a small percentage of substance use treatment facilities reported having a program that treats patients with co-occurring pain and SUD. Given the known high prevalence of co-occurring pain and SUD, further understanding of the role of these programs and barriers to implementation may enhance acceptance in treatment programs.
Seasonal variations of nonmotor symptoms in patients with Parkinson's disease in Southeast China
Authors: Wang Jingyi , Xiong Kangping , Chao Jingyuan , Zhuang Sheng , Li Jie , Liu Chunfeng 
Published: August 2022

Abstract

Background:
Studies suggest seasonal fluctuations of symptoms in Parkinson's disease (PD) patients in Western countries. However, the association between seasonal change and variation in nonmotor symptoms (NMS) in Chinese PD patients is unclear. Here, we studied whether there is a change rule with annual cycle with severity of NMS for patients with PD in Southeast China.

Methods:
We studied 1005 PD patients between April 2008 and October 2020. Patients were classified into four seasons according to the 24 Chinese solar terms, based on assessment date. We compared comprehensive NMS scales and polysomnography parameters among groups and conducted further analysis of disease severity.

Results:
Among the 1005 patients studied, the mean age was 64.2 ± 9.7 years and 569 (56.6%) of them were men. Relative to the summer group, patients assessed during winter had higher Scales for Outcomes in Parkinson's disease-Autonomic Dysfunction (SCOPA-AUT) scores (P = 0.045). The sleep efficiency factor scores of Pittsburgh Sleep Quality Index in patients were higher during spring than summer (P = 0.009). Among patients who completed polysomnography during the same period (n = 135), compared with summer follow-ups, we observed a higher percentage of NREMS1 in winter and spring follow-ups (P = 0.042, P = 0.011), a higher NREMS1 time in spring follow-ups (P = 0.0024), a lower NREMS2 time in winter follow-ups (P = 0.007), and a higher percentage of phasic RSWA in autumn and winter follow-ups (P = 0.026 and P = 0.020, respectively). In a subset of patients with PD and REM sleep behavior disorder (RBD; n = 182), those visited during winter had higher scores for RBD questionnaire- Hong Kong and its factor 1 (dream-related sub-score) than those visited during summer (P = 0.034, P = 0.020). We observed similar findings for SCOPA-AUT and sleep efficiency factor scores in early stage patients in subgroup analysis.

Conclusions:
PD patients assessed for follow-up during summer showed less severe symptoms of autonomic dysfunction and RBD symptoms than those assessed in winter, and less sleep disturbance than those in spring and winter, suggesting that seasonal change and NMS fluctuation are related, especially in patients with early stage PD.
Statin and Postcardiac Surgery Atrial Fibrillation Prevention: A Systematic Review and Meta-Analysis
Authors: Oliveri Federico , Bongiorno Andrea , Compagnoni Sara , Fasolino Alessandro , Gentile Francesca Romana , Pepe Antonella , Tua Lorenzo 
Published: August 2022

Abstract:
Postoperative atrial fibrillation (POAF) is a frequently reported postcardiac surgery complication leading to increased in-hospital and long-term mortality rates. Many randomized controlled trials (RCTs) have recently suggested using statins to protect against POAF. Therefore, we performed a systematic literature search and meta-analysis in electronic databases for eligible studies published between January 2006 and January 2022. The principal inclusion criteria were as follows: RCTs' study design, statin-naive patients, total study participants ≥50 units, and statin pretreatment started no more than 21 days before cardiac surgery. In the primary analysis, statin pretreatment reduced the incidence of POAF compared with placebo. Analyzing different molecules, atorvastatin was associated with lower incidence of POAF but rosuvastatin was not. We therefore performed a sensitivity analysis excluding RCTs affected by important risk of biases. Thus, studies whose participants were ≥199 were those eligible for the secondary analysis. No statistically significant difference between statin pretreatment and placebo (OR 0.87; 95% CI: 0.71–1.07, P = 0.18) as well as for atorvastatin (OR 0.88; 95% CI: 0.61–1.28; P = 0.48; I2 = 84%) and rosuvastatin (OR 0.87; 95% CI: 0.68–1.12, P = 0.29) was observed. To conclude, statin pretreatment before cardiac surgery is not associated with a significant reduction in POAF occurrence.