bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges and Barriers of Humanitarian Hygiene Items Management in Recent Disasters in Iran
Authors: Adibi Larijani Haleh , Moslehi Shandiz , Barghi Shirazi Fahimeh , Pashaee Asl Yosef , Alikhani Afshin , Fatemi Farin 
Published: May 2022

Abstract

Objective:
The provision and continuation of the basic needs of affected communities, including water, food, and shelter remain the most important priorities in responding to disasters. In this regard, this study sought to investigate the management challenges of humanitarian hygiene items in recent disasters in Iran.

Methods:
This qualitative study was conducted through a semi-structured interview. Nineteen participants with different experiences, roles, and responsibilities in the recent disaster of Iran and experiences of various events in the national and international arenas were included in the study. A thematic analysis was used, and an initial conceptual framework was defined based on the study aim. The relationship between the components was compared and interpreted in this framework and the main and subthemes were extracted accordingly.

Results:
Six main themes and 21 subthemes were extracted based on the results. The main challenges in recent disasters were the lack of protocols and standard guidelines, inappropriate selection of items in each hygiene kit, the lack of standard distribution of hygiene kits, and the lack of attention to the affected population’s culture.

Conclusions:
Overall, it is necessary to define a system for preparation, supply, storage, and timely distribution of hygiene. Finally, it is suggested that an organization should be appointed for this purpose.
The effect of a novel herbicide adjuvant in treating Amur honeysuckle (Lonicera maackii)
Authors: Rivera Benjamin J. , Meilan Richard , Scharf Michael E. , Karve Rucha A , Jenkins Michael A. 
Published: May 2022

AbstractInvasive woody perennials pose an immense threat to the diversity and function of many ecosystems, including forests in the eastern United States. While herbicide treatments have proven effective in controlling many plant invasions, there is considerable interest in the refinement of herbicide prescriptions to improve efficacy and prevent non-target damage. Adjuvants are widely utilized to improve herbicide efficacy, but research on novel adjuvants is often lacking. Furthermore, adjuvant research has generally focused on enhancement of foliar herbicide absorption, and few studies focus on adjuvant utility for other herbicide delivery techniques such as cut stump treatments. We evaluated 2XL—a cocktail of cellulase enzymes derived from fungi—as a potential herbicide adjuvant for use with glyphosate applied in a cut stump treatment due to its ability to degrade a key component of cell walls. We conducted a field experiment using the cut stump method of treatment (cut surface treated with herbicide) on a problematic invasive shrub, Amur honeysuckle [Lonicera maackii (Rupr.) Herder]. We tested combinations of three concentrations of 2XL with five concentrations of glyphosate and hypothesized that low concentrations of glyphosate combined with 2XL would be as effective in limiting the resprouting of L. maackii as higher concentrations of glyphosate without the enzymes. Our results indicated that 2XL did not improve glyphosate efficacy for reducing the number of resprouting stems or the length of the longest resprouting stem within the same or following year as treatment. Limited data indicated the combination of 2XL and glyphosate applied at 30 g L−1 slightly increased resprouting in the year following treatment. While 2XL did not improve glyphosate efficacy, our results showed effective control of L. maackii at the lowest concentration of glyphosate tested (30 g L−1), suggesting that concentrations lower than those typically applied may be effective in controlling L. maackii within parameters similar to those tested here.
The Flowering of British Sinology
Authors: Barrett T.H. 
Published: May 2022

AbstractThis account of Sinology in the United Kingdom, in part incorporating personal reminiscence, starts with an analysis of the growth of the British library resources necessary to the practice of Sinology, followed by a sketch of the marginality in Britain in the early twentieth century of this type of scholarship. The changes brought about by the military requirements of World War II are seen as foreshadowing an era during which large-scale funding in Asian and other studies briefly allowed Sinology to flourish, after which a failure to understand the benefits of training in a non-spoken language reduced the opportunities for British students to the point where British Sinology is virtually extinct, and the willingness of scholars from elsewhere in Europe to engage with British university life is being sorely tried. The contributions of British Sinology, supported by Chinese and other incomers during its efflorescence, are briefly surveyed.
Mergers and Acquisitions and the Incorporation of the Public Interest in Africa's Regional Competition Laws: A Case Study of COMESA
Authors: Ndlovu Precious N 
Published: May 2022

AbstractPublic interest issues have the potential to play a significant role in the evaluation of mergers and acquisitions in Africa's regional competition laws. A case in point is the Common Market for Eastern and Southern Africa (COMESA): its regional competition authorities have jurisdiction to evaluate transactions within the Common Market. To that end, COMESA's regional competition law enumerates specific public interest factors regarding mergers and acquisitions. Further, COMESA's regional competition law permits the consideration of additional factors under the rubric of public interest, without specifying what these factors are. On this basis, COMESA's regional competition authorities have gradually created precedents on incorporating public interest considerations. This illustrates the point that purist positions towards competition law do not serve Africa's socio-economic development goals. Therefore, the challenge facing COMESA's regional competition authorities is the application of the public interest in a manner that remains faithful to the economic doctrine that underpins competition law.
Improved multispecies Dougherty collisions
Authors: Francisquez Manaure , Juno James , Hakim Ammar , Hammett Gregory W. , Ernst Darin R. 
Published: May 2022

The Dougherty model Fokker–Planck operator is extended to describe nonlinear full-

$f$

( f is the distribution function) collisions between multiple species in plasmas. Simple relations for cross-species primitive moments are developed which obey conservation laws, and reproduce familiar velocity and temperature relaxation rates. This treatment of multispecies Dougherty collisions, valid for arbitrary mass ratios, avoids unphysical temperatures and satisfies the

$H$

-theorem (H is related to the entropy) unlike an analogous Bhatnagar–Gross–Krook operator. Formulas for both a Cartesian velocity space and a gyroaveraged operator are provided for use in Vlasov as well as long-wavelength gyrokinetic models. We present an algorithm for the discontinuous Galerkin discretization of this operator, and provide results from relaxation and Landau damping benchmarks.
Assessing the role of imported cases on the establishment of SARS-CoV-2 Delta variant of concern in Bolton, UK
Authors: Shingleton Joseph , Finnie Thomas , Gent Nick , Bennett Emma 
Published: May 2022

Abstract
This paper presents a method used to rapidly assess the incursion and the establishment of community transmission of suspected SARS-CoV-2 variant of concern Delta (lineage B.1.617.2) into the UK in April and May 2021. The method described is independent of any genetically sequenced data, and so avoids the inherent lag times involved in sequencing of cases. We show that, between 1 April and 12 May 2021, there was a strong correlation between local authorities with high numbers of imported positive cases from India and high COVID-19 case rates, and that this relationship holds as we look at finer geographic detail. Further, we also show that Bolton was an outlier in the relationship, having the highest COVID-19 case rates despite relatively few importations. We use an artificial neural network trained on demographic data, to show that observed importations in Bolton were consistent with similar areas. Finally, using an SEIR transmission model, we show that imported positive cases were a contributing factor to persistent transmission in a number of local authorities, however they could not account for increased case rates observed in Bolton. As such, the outbreak of Delta variant in Bolton was likely not a result of direct importation from overseas, but rather secondary transmission from other regions within the UK.
Neurologic complications of infective endocarditis in children
Authors: Jacobwitz Marin , Favilla Emmanuelle , Patel Amisha , Giglia Therese M. , Taing Kimberly , Ravishankar Chitra , Gaynor J. William , Licht Daniel J. , McGuire Jennifer L. , Beslow Lauren A. 
Published: May 2022

AbstractObjectives:To define the frequency and characteristics of acute neurologic complications in children hospitalised with infective endocarditis and to identify risk factors for neurologic complications.Study Design:Retrospective cohort study of children aged 0–18 years hospitalised at a tertiary children’s hospital from 1 January, 2008 to 31 December, 2017 with infective endocarditis.Results:Sixty-eight children met Duke criteria for infective endocarditis (43 definite and 25 possible). Twenty-three (34%) had identified neurologic complications, including intracranial haemorrhage (25%, 17/68) and ischaemic stroke (25%, 17/68). Neurologic symptoms began a median of 4.5 days after infective endocarditis symptom onset (interquartile range 1, 25 days), though five children were asymptomatic and diagnosed on screening neuroimaging only. Overall, only 56% (38/68) underwent neuroimaging during acute hospitalisation, so additional asymptomatic neurologic complications may have been missed. Children with identified neurologic complications compared to those without were older (48 versus 22% ≥ 13 years old, p = 0.031), more often had definite rather than possible infective endocarditis (96 versus 47%, p < 0.001), mobile vegetations >10mm (30 versus 11%, p = 0.048), and vegetations with the potential for systemic embolisation (65 versus 29%, p = 0.004). Six children died (9%), all of whom had neurologic complications.Conclusions:Neurologic complications of infective endocarditis were common (34%) and associated with mortality. The true frequency of neurologic complications was likely higher because asymptomatic cases may have been missed without screening neuroimaging. Moving forward, we advocate that all children with infective endocarditis have neurologic consultation, examination, and screening neuroimaging. Additional prospective studies are needed to determine whether early identification of neurologic abnormalities may direct management and ultimately reduce neurologic morbidity and overall mortality.
Whither Winter: The Altered Role of Winter for Freshwaters as the Climate Changes
Authors: Cotner James B. , Powers Stephen M. , Sadro Steven , McKnight Diane 
Published: May 2022

AbstractOur changing climate is having effects on freshwater ecosystems in all seasons, especially winter. High latitude lakes, wetlands, and rivers are experiencing shorter periods of ice cover, and lower latitudes systems that used to freeze are experiencing open water conditions throughout the winter. A 2019 AGU Chapman conference convened aquatic scientists to examine these changes and address the implications of changing winters to aquatic life, chemistry, and physics. Several studies demonstrate decreased ice cover duration than in the past. The removal of an ice “lid” from lakes and rivers impacts the exchange of gases with the atmosphere and the predominant types of metabolism occurring in the waters below, with the potential for more photosynthesis and an increase in oxic versus anoxic metabolism when the lid is removed. Multiple studies indicated an increase in the interannual variability of winters, especially in terms of ice‐cover duration and ice quality. Increased variability may simply be an outcome of a more variable winter climate or small differences in environmental conditions such as temperature that can have strong effects on gas exchange, light transmission, and turbulence when ice forms. A question that merits further consideration is whether and how winters of shorter duration and severity will change the dynamics of freshwater systems. Are there memory or legacy effects that carry over to the next season or year? There is much work to be done to understand how changing winters will impact the biogeochemical behavior of lakes and rivers in the coming decades.
Tim-3+ decidual Mφs induced Th2 and Treg bias in decidual CD4+T cells and promoted pregnancy maintenance via CD132
Authors: Li Mengdie , Sun Fengrun , Xu Yuanyuan , Chen Lanting , Chen Chunqin , Cui Liyuan , Qian Jinfeng , Li Dajin , Wang Songcun , Du Meirong 
Published: May 2022

AbstractT-cell immunoglobulin mucin-3 (Tim-3) plays roles in the functional regulation of both adaptive and innate immune cells and is greatly involved in many diseases. However, the precise roles of Tim-3 on macrophages (Mφs) in pregnancy remain unstated. In the current study, we found the higher frequency of Tim-3+ decidual Mφs (dMφs) in response to trophoblasts. The reduced abundance of Tim-3 on Mφs was accompanied by disordered anti- and pro-inflammatory cytokine profiles in miscarriage. Adoptive transfer of Tim-3+Mφs, but not Tim-3−Mφs, relieved murine embryo absorption induced by Mφ depletion. Our flow cytometry results and the extensive microarray analysis confirmed that Tim-3+ and Tim-3−dMφs were neither precisely pro-inflammatory (M1) nor anti-inflammatory (M2) Mφs. However, with higher CD132 expression, Tim-3+dMφs subset induced Th2 and Treg bias in decidual CD4+T cells and promoted pregnancy maintenance. Blockade of Tim-3 or CD132 pathways leaded to the dysfunction of maternal-fetal tolerance and increased fetal loss. These findings underscored the important roles of Tim-3 in regulating dMφ function and maintaining normal pregnancy, and suggested that Tim-3 on Mφs is a potential biomarker for diagnosis of miscarriage. Our study also emphasized the importance of careful consideration of reproductive safety when choosing immune checkpoint blockade therapies in real world clinical care. Though IL-4 treated Tim-3−Mφs could rescue the fetal resorption induced by Mφ depletion, whether IL-4 represent novel therapeutic strategy to prevent pregnancy loss induced by checkpoint inhibition still needs further research.
22 years of satellite imagery reveal a major destabilization structure at Piton de la Fournaise
Authors: Dumont Quentin , Cayol Valérie , Froger Jean-Luc , Peltier Aline 
Published: May 2022

AbstractVolcanic activity can induce flank failure, sometimes generating large earthquakes and tsunamis. However, the failure structures have never been fully characterized and the failure mechanism is still debated. Magmatic activity is a possible trigger, either through fault slip, which might be induced by dyke intrusions, or through sill intrusions, which might be undergoing coeval normal displacements and slip. At the Piton de la Fournaise volcano, satellite imagery combined with inverse modeling highlights the pathways of 57 magmatic intrusions that took place between 1998 and 2020. We show that a major arcuate dyke intrusion zone is connected at depth to a sill intrusion zone, which becomes a fault zone towards the sea, forming a spoon-shaped structure. Some sills are affected by coeval normal displacement and seaward slip. Overall, the structure is characterized by a continuum of displacement from no slip, to sheared sills and finally pure slip. Repeated intrusions into this spoon-shaped structure could trigger catastrophic collapses.
Arabidopsis cryptochrome 2 forms photobodies with TCP22 under blue light and regulates the circadian clock
Authors: Mo Weiliang , Zhang Junchuan , Zhang Li , Yang Zhenming , Yang Liang , Yao Nan , Xiao Yong , Li Tianhong , Li Yaxing , Zhang Guangmei , Bian Mingdi , Du Xinglin , Zuo Zecheng 
Published: May 2022

AbstractCryptochromes are blue light receptors that regulate plant growth and development. They also act as the core components of the central clock oscillator in animals. Although plant cryptochromes have been reported to regulate the circadian clock in blue light, how they do so is unclear. Here we show that Arabidopsis cryptochrome 2 (CRY2) forms photobodies with the TCP22 transcription factor in response to blue light in plant cells. We provide evidence that PPK kinases influence the characteristics of these photobodies and that together these components, along with LWD transcriptional regulators, can positively regulate the expression of CCA1 encoding a central component of the circadian oscillator.
Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells
Authors: Omatsu Yoshiki , Aiba Shota , Maeta Tomonori , Higaki Kei , Aoki Kazunari , Watanabe Hitomi , Kondoh Gen , Nishimura Riko , Takeda Shu , Chung Ung-il , Nagasawa Takashi 
Published: May 2022

AbstractIn bone marrow, special microenvironments, known as niches, are essential for the maintenance of hematopoietic stem cells (HSCs). A population of mesenchymal stem cells, termed CXC chemokine ligand 12 (CXCL12)-abundant reticular (CAR) cells or leptin receptor-expressing cells are the major cellular component of HSC niches. The molecular regulation of HSC niche properties is not fully understood. The role of Runx transcription factors, Runx1 and Runx2 in HSC cellular niches remains unclear. Here we show that Runx1 is predominantly expressed in CAR cells and that mice lacking both Runx1 and Runx2 in CAR cells display an increase in fibrosis and bone formation with markedly reduced hematopoietic stem and progenitor cells in bone marrow. In vitro, Runx1 is induced by the transcription factor Foxc1 and decreases fibrotic gene expression in CAR cells. Thus, HSC cellular niches require Runx1 or Runx2 to prevent their fibrotic conversion and maintain HSCs and hematopoiesis in adults.
Skilful decadal-scale prediction of fish habitat and distribution shifts
Authors: Payne Mark R. , Danabasoglu Gokhan , Keenlyside Noel , Matei Daniela , Miesner Anna K. , Yang Shuting , Yeager Stephen G. 
Published: May 2022

AbstractMany fish and marine organisms are responding to our planet’s changing climate by shifting their distribution. Such shifts can drive international conflicts and are highly problematic for the communities and businesses that depend on these living marine resources. Advances in climate prediction mean that in some regions the drivers of these shifts can be forecast up to a decade ahead, although forecasts of distribution shifts on this critical time-scale, while highly sought after by stakeholders, have yet to materialise. Here, we demonstrate the application of decadal-scale climate predictions to the habitat and distribution of marine fish species. We show statistically significant forecast skill of individual years that outperform baseline forecasts 3–10 years ahead; forecasts of multi-year averages perform even better, yielding correlation coefficients in excess of 0.90 in some cases. We also demonstrate that the habitat shifts underlying conflicts over Atlantic mackerel fishing rights could have been foreseen. Our results show that climate predictions can provide information of direct relevance to stakeholders on the decadal-scale. This tool will be critical in foreseeing, adapting to and coping with the challenges of a changing future climate, particularly in the most ocean-dependent nations and communities.
In vitro reconstitution of Escherichia coli divisome activation
Authors: Radler Philipp , Baranova Natalia , Caldas Paulo , Sommer Christoph , López-Pelegrín Mar , Michalik David , Loose Martin 
Published: May 2022

AbstractThe actin-homologue FtsA is essential for E. coli cell division, as it links FtsZ filaments in the Z-ring to transmembrane proteins. FtsA is thought to initiate cell constriction by switching from an inactive polymeric to an active monomeric conformation, which recruits downstream proteins and stabilizes the Z-ring. However, direct biochemical evidence for this mechanism is missing. Here, we use reconstitution experiments and quantitative fluorescence microscopy to study divisome activation in vitro. By comparing wild-type FtsA with FtsA R286W, we find that this hyperactive mutant outperforms FtsA WT in replicating FtsZ treadmilling dynamics, FtsZ filament stabilization and recruitment of FtsN. We could attribute these differences to a faster exchange and denser packing of FtsA R286W below FtsZ filaments. Using FRET microscopy, we also find that FtsN binding promotes FtsA self-interaction. We propose that in the active divisome FtsA and FtsN exist as a dynamic copolymer that follows treadmilling filaments of FtsZ.
Active conformation of the p97-p47 unfoldase complex
Authors: Xu Yang , Han Han , Cooney Ian , Guo Yuxuan , Moran Noah G. , Zuniga Nathan R. , Price John C. , Hill Christopher P. , Shen Peter S. 
Published: May 2022

AbstractThe p97 AAA+ATPase is an essential and abundant regulator of protein homeostasis that plays a central role in unfolding ubiquitylated substrates. Here we report two cryo-EM structures of human p97 in complex with its p47 adaptor. One of the conformations is six-fold symmetric, corresponds to previously reported structures of p97, and lacks bound substrate. The other structure adopts a helical conformation, displays substrate running in an extended conformation through the pore of the p97 hexamer, and resembles structures reported for other AAA unfoldases. These findings support the model that p97 utilizes a “hand-over-hand” mechanism in which two residues of the substrate are translocated for hydrolysis of two ATPs, one in each of the two p97 AAA ATPase rings. Proteomics analysis supports the model that one p97 complex can bind multiple substrate adaptors or binding partners, and can process substrates with multiple types of ubiquitin modification.
Clustering and halogen effects enabled red/near-infrared room temperature phosphorescence from aliphatic cyclic imides
Authors: Zhu Tianwen , Yang Tianjia , Zhang Qiang , Yuan Wang Zhang 
Published: May 2022

AbstractPure organic room temperature phosphorescence (RTP) materials become increasingly important in advanced optoelectronic and bioelectronic applications. Current phosphors based on small aromatic molecules show emission characteristics generally limited to short wavelengths. It remains an enormous challenge to achieve red and near-infrared (NIR) RTP, particularly for those from nonaromatics. Here we demonstrate that succinimide derived cyclic imides can emit RTP in the red (665, 690 nm) and NIR (745 nm) spectral range with high efficiencies of up to 9.2%. Despite their rather limited molecular conjugations, their unique emission stems from the presence of the imide unit and heavy atoms, effective molecular clustering, and the electron delocalization of halogens. We further demonstrate that the presence of heavy atoms like halogen or chalcogen atoms in these systems is important to facilitate intersystem crossing as well as to extend through-space conjugation and to enable rigidified conformations. This universal strategy paves the way to the design of nonconventional luminophores with long wavelength emission and for emerging applications.