bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacts of primary tumor location on outcomes in patients undergoing hepatectomy for colorectal liver metastasis vary according to tumor burden
Authors: Wang Hong-Wei , Wang Li-Jun , Li Juan , Wang Kun , Xing Bao-Cai 
Published: November 2022

PurposeThe purpose of this study was to verify whether the prognostic value of primary tumor location (PTL) for patients undergoing resection for colorectal liver metastasis (CRLM) is affected by tumor burden.MethodsPatients who underwent a first curative-intent surgery for CRLM from 2006 to 2017 were enrolled. The imaging tumor burden score (TBS) was calculated as TBS2 = (maximum tumor diameter in cm)2 + (number of lesions)2. Then, the prognostic role of PTL was assessed in different TBS zones.ResultsThe patient population consisted of 524 left-sided (LS) and 118 right-sided (RS) primary tumors. The distribution of TBS in the patient cohort was: Zone1: TBS &lt;3 [n = 161 (25.1%)], zone 2: TBS ≥3 to &lt;7 [n = 343 (53.4%)], and zone 3: TBS ≥7 [n = 138 (21.5%)]. In the whole cohort, the 5-year overall survival (OS) in the RS group was worse than that in the LS group (35.6% vs. 45.4%). However, after adjustment for known prognostic confounders, the RS group was not independently associated with a poorer OS (HR 1.18, p = 0.247). Among patients with TBS &lt;7, OS in the RS group was significantly shorter than that in the LS group in both univariate and multivariate analyses. The prognostic role of PTL remained significant after propensity score matching or excluding patients who received anti-EGFR agents. Conversely, the association between PTL and OS was no longer evident in patients with TBS ≥7.ConclusionThe current study demonstrates that the prognostic value of PTL varies by TBS, and RS tumors are only associated with shorter survival in patients with low or medium TBS.
Functional Conservation and Divergence of MOS1 That Controls Flowering Time and Seed Size in Rice and Arabidopsis
Authors: Lu Shan , Zhang Ning , Xu Yazhen , Chen Hao , Huang Jie , Zou Baohong 
Published: November 2022

The heading date and grain size are two essential traits affecting rice yield. Here, we found that OsMOS1 promotes rice heading and affects its grain size. Knocking out OsMOS1 delayed heading, while the overexpression of OsMOS1 promoted heading in rice under long-day conditions. The transcriptions of the heading activators Ehd1, Hd3a, and RFT1 were decreased and the heading repressor Hd1 was increased in the osmos1 mutant. Conversely, the overexpression of OsMOS1 promoted the expressions of Ehd1, Hd3a, and RFT1, but inhibited the expression of Hd1. This suggests that OsMOS1 may control heading in rice by modulating the transcriptions of Ehd1, Hd3a, RFT1, and Hd1. In addition, knocking out OsMOS1 led to larger grains with longer grain lengths and higher grain weights. The seed cell size measurement showed that the cell lengths and cell widths of the outer glume epidermal cells of the osmos1 mutant were greater than those of the wild type. Furthermore, we also found that the overexpression of OsMOS1 in the Arabidopsis mos1 mutant background could suppress its phenotypes of late flowering and increased seed size. Thus, our study shows a conserved function of MOS1 in rice and Arabidopsis, and these findings shed light on the heading and seed size regulation in rice and suggest that OsMOS1 is a promising target for rice yield improvement.
MULTIPLE SCLEROSIS AND PREGNANCY: STATUS OF THE PROBLEM AND CLINICAL EXPERIENCE
Authors: SHEVCHENKO O.S. , HUSIEVA A.YE. , BULYK L.M. , MEDVED V.I. 
Published: November 2022

The aim of the study is to study the course of pregnancy, childbirth and postpartum period, the condition of newborns in patients with multiple sclerosis, and to analyze the obtained results in comparison with similar data from modern scientific and medical literature.
Materials and research methods. An observational study of the course of pregnancy, childbirth, postpartum period, and the condition of newborns was conducted in 27 patients with multiple sclerosis (main group) and 56 somatically healthy pregnant women (control group).
Research results and their discussion. During 10 years (2011-2020), 27 women with multiple sclerosis were observed and gave birth in the department of internal pathology of pregnant women. The average age was 28 ± 8 years. According to the duration of the disease, the patients were distributed as follows: up to 2 years - 8 (29.6%), 2-3 years - 6 (22.2%), 4-5 years - 3 (11.1%), 6 years - 4 (14.8%), 9 years - 1 (3.7%), 10 years - 3 (11.1%), 12 years - 2 (7.4%). Among all observed women, five (18.5%) had no complications during pregnancy, the remaining 22 (81.5%) had various problems. Concomitant extragenital pathology occurred in 21 women (77.8%). Childbirth on time (37-41 weeks) occurred in 24 women, premature childbirth in 33-35 weeks occurred in 3 women. 15 women (55.6%) gave birth through the natural birth canal, the remaining 12 women (44.4%) - by caesarean section. All children were born alive: 12 boys and 15 girls. 21 women gave birth to healthy children (77.8%), 3 (11.1%) had small gestational age and 2 (7.4%) had atelectatic pneumonia. Women’s misconceptions about the adverse effect of pregnancy on the coursed of multiple sclerosis, as well as the disease itself on the course of pregnancy and, possibly, the development of the fetus, is today the main obstacle to motherhood in multiple sclerosis. Understanding the relationship between pregnancy and the late development of the disease can be the basis for modern therapy of this disease, which will largely prevent the development of severe complications and disability.
Conclusion. After the diagnosis of multiple sclerosis, all women of childbearing age should be counseled about pregnancy planning. Doctors must take into account the safety of medications that the patient constantly receives during pregnancy. The presence of this disease does not affect fertility.
FUTUROLOGICAL EXPLANATIONS OF THE NEW UKRAINIAN EDUCATIONAL POLICY
Authors: Nezhyva O. 
Published: November 2022

The article considers the peculiarities of futurological explications of the new educational policy in Ukraine. It also shows the existing contradictions in the development of the state education policy of Ukraine and the importance for transitive societies of its formation on a democratic basis, actualizing the development and implementation of the policy of reforming the national education system. At the same time, the peculiarities of the formation and development of the Soviet and European education system are analyzed. Each of them has certain advantages and disadvantages. The article notes that educational policy should move away from monosubjectivity and become polysubjective. To do this, it should be based on state, as well as on public, social mechanisms of activity regulation, make and keep a favorable environment for the existence and functioning of other opportunities, which is a necessary condition for the establishment of free educational interaction and the understanding of education as a practice of freedom. The article illustrates the main provisions of the Ukrainian educational policy based on the Ukrainian national idea. These provisions provide for the following: education policy of Ukraine should be based on the recognition of the fact of the birth of individuality, as well as be based on the principle of "do no harm"; an individual approach to pupils and students requires certain changes in the organization of the system; relevance of the language issue in education; it is necessary to establish independent public control over the quality of educational services provided and their compliance with modern world standards; it is necessary to go away from the trendy of the received diploma, and it is also necessary to strive for constant professional growth of all categories of the population: from teachers to motorists. The article illustrates the main provisions of the Ukrainian educational policy based on the Ukrainian national idea. These provisions provide for the following: Ukrainian educational policy should be based on the recognition of the fact of the birth of individuality, as well as be based on the principle of "do no harm"; an individual approach to pupils and students requires certain changes in the organization of the system; relevance of the language issue in education; it is necessary to establish free public control over the quality of educational services provided and their compliance with modern world standards; it is necessary to go away from the cult of the received diploma, and it is also necessary to strive for constant professional growth of all categories of the population: from teachers to motorists. And this growth should be accompanied by diplomas obtained, and from educational institutions of authority not only in Ukraine, but also abroad. Besides, this growth should be accompanied by diplomas obtained, and from educational institutions of authority not only in Ukraine, but also abroad.
Hybrid thermoelectric-photovoltaic solar harvesters: technological and economic issues
Authors: Narducci Dario , Lorenzi Bruno 
Published: November 2022

Abstract
The possibility of recovering heat released by photovoltaic (PV) solar cells into electric power by using thermoelectric generators has attracted a remarkable research effort over the last two decades. Views and results are not fully converging, however, ranging from overoptimistic estimates of power gains to fully negative opinions about the convenience of hybridization. The aim of this paper is to review both energetic and economic profitability of photovoltaic-thermoelectric hybridization, as both issues are to be considered in the design of hybrid solar harvesters. It will be shown how the PV material rules the total system efficiency and its economic competitiveness compared to standard PV modules. Marginal opportunities are reported for roof-top concentrated solar harvesters. Yet, hybridization may leverage novel PV materials, currently not considered due to their lower efficiency compared to polycrystalline silicon. Much more significant is instead the window of opportunity when thermoelectric generators are coupled to perovskite solar cells.
Why Eucalyptus Citriodora Potential as Biopesticide ?
Authors: Maris Paramita , Utami Dwi Susilo , Marwoto Otto , Tarigan Nurbetti 
Published: November 2022

Various efforts have been made to eliminate or at least reduce the negative impact of chemical pesticides that are currently widely used. One of these efforts is to use other effective control alternatives, such as bio-pesticides/botanical pesticides. Eucalyptus citriodora essential oil was previously better known in traditional medicine. However, many studies have shown that this essential oil has much potential to be used as a biopesticide. This article reviews the biopesticide potential of E. citriodora essential oil, including its herbicidal, bactericidal, fungicidal, nematicidal, insect-repellent, and insecticidal activities. E. citriodora oil contains citronellal, citronellol, 1,8-cineole, isopulegol, ?-pinene, and citronellyl acetate. Citronellal and citronellol are one of the main toxins in E. citriodora essential oil. However, this review shows that the oil has a broad spectrum of biological activity, making it a simple and environmentally friendly pesticide.
Effect of Persistent Hyperglycemia and Lipid Profile and its role in Glycation and Oxidative stress in Chronic Type 2 Diabetes Mellitus subjects
Authors: Kafle Deepak 
Published: November 2022

Introduction: Diabetes mellitus is a disease of carbohydrate metabolism disorder which results in increase in blood glucose level. Hyperglycemia may increase oxidative stress through a variety of ways impairs an antioxidant defenses mechanism. Reactive oxygen species are increased as a result of the oxidative stress caused by hyperglycemia, which activates a number of redox-sensitive cell signaling molecules producing cytotoxic materials.
Methods: 250 randomly visited the OPD at the Chitwan Medical College Department of Medicine were chosen for this cross-sectional study. 10ml of blood sample was drawn from anticubital vein following overnight fasting and was centrifuged at room temperature for 10 minutes at 3000 rpm. The serum was stored at 4oC for biochemical investigations. Fasting blood sugar, lipid profile and HbA1c etc. were analyzed via chemiluminescence Analyzer (CLIA) in the Hospital Laboratory of Chitwan Medical College. With SPSS version 22, statistical analysis was carried out.
Results: IIt was found from the study that type 2 diabetic subjects have significant increase of fasting blood sugar and malondialdehyde (MDA) but glutathione peroxidase was found to be decreased in type 2 diabetic subjects as compared to healthy controls. Glutathione reductase was found non-significant at (P>0.05) in both the subjects. It was found from the study that association of HbA1c with Total cholesterol, Triglyceride, LDL-C was found to be positively correlated and was significant at P<0.05.
Conclusions: When predicting glycemic control in T2DM patients, lipid profiles (LDL-C) and glycation status can be helpful tools.
Assessment of dental myths and misconceptions among the people of Chitwan, Nepal
Authors: Chhatkuli Ayam , Kafle Shristi , Balami Saroj , Chaulagain Rajib 
Published: November 2022

Introduction: Even though, dentistry has developed a lot in present days, dental myths and misconceptions still exist which is also in a way creating hinderance in accepting the advanced curative, preventive treatments. The present study was aimed to assess the prevalent dental myths and misconceptions among the people of Chitwan, Nepal.
Methods: This was a descriptive cross-sectional study conducted among 250 residents of Chitwan, Nepal, from 15th July 2021 to 15th August 2021. A convenience sampling method was employed to collect the data from the residents of Chitwan. A self-administered questionnaire was used. The data was entered into Microsoft Excel Version 2019 and later transferred into Statistical Package of Social Science (SPSS) version 16 and analysed using descriptive statistics (mean, standard deviation, frequency and percentage).
Results: There were in total 250 residents of Chitwan who participated in the study. The mean age of participants was 52.51±10.23 years. Among the 250 participants 153 (61.2%) were females and 97 (38.8 were females). About 108 (43.2%) participants believed that dental pain can be reduced by visiting shaman, hermits and monks. While 146 (58.4%) agreed that extraction of upper teeth affects eye vision, 152 (60.8%) were positive towards association of wisdom tooth with human intelligence. About 66.8% believed that charcoal whitens the tooth.
Conclusions: The present study concluded that dental myths are prevalent among the residents of Chitwan. These myths should be addressed by creating awareness programs from the community level.
Peran Ma’had Darul Qur’an Wal Adist Nw Pancor Dalam Membentuk Relasi Sosial Yang Berkarakter
Authors: Jiddan Masrur , Tarmizi Muh. 
Published: November 2022

Pesantren merupakan lembaga pendidikan tertua di Indonesia, yang secara nyata telah melahirkan banyak ulama sebagai transmisi dan transfer ilmu-ilmu keislaman, menjaga tradisi, dan refroduksi ulama. Selain itu juga, Peran Pesantren tumbuh dalam Masyarakat untuk melayani berbagai kebutuhan Masyarakat. Pesantren pun tumbuh munjadi lemabaga keagamaan yang melakukan kontrol sosial dan juga rekayasa sosial. Bahkan, di saat pendidikan moderen, sekolah dan madrasah, belum menjamah pelosok pedalaman/pedesaan, pesantren mampu menjadi lembaga pendidikan masyarakat.
Pesantren juga berperan sebagai tempat mempelajari ilmu pengetahuan khususnya ilmu agama yang dimana untuk mempelajari, memahami, mendalami, menghayati, dan mengajarkan agama islam dengan menekankan pentingnya moral sebagai identitas lembaga pendidikan islam dan merupakan duplikasi dari masyarakat
Taking the path of least resistance now, but not later: Pushing cognitive effort into the future reduces effort discounting
Authors: Johnson S. Tobias , Most Steven B. 
Published: November 2022

AbstractEffort discounting describes the devaluation of rewards that require effort to obtain. The present study investigated whether discounting of cognitive effort depends on how near the effort is in time. The present study also investigated whether effort discounting, and its modulation by temporal distance to the effort, might depend on need for cognition, a personality trait that describes how much one enjoys cognitively demanding tasks. Participants performed a validated effort discounting task that measured the extent to which they subjectively devalued a $20 reward when effort was required to receive it. Immediacy of the effort was manipulated by having participants imagine exerting varying levels of effort either immediately, in a day, or in a month. Results revealed linear increases in discounting of rewards as a function of both how much effort was involved and how imminent the effort was. The extent to which both these variables influenced discounting correlated with need for cognition. Individuals low in need for cognition exhibited more effort discounting overall and a linear increase in effort discounting as the effort grew imminent. Individuals high in need for cognition engaged in less effort discounting, which was not modulated by how imminent the effort was. These results indicate that people exhibit dynamic inconsistency in effort-related decisions, such that the degree to which they discount effort depends on how soon the effort is. Additionally, this tendency is linked with systematic individual differences in need for cognition. Lastly, this study demonstrates that these tendencies can be quantitatively operationalized.
Searching for the Signal of a Primordial Black Hole from CMB Lensing and γ-Ray Emissions
Authors: Tan Xiu-Hui , Yan Yang-Jie , Qiu Taotao , Xia Jun-Qing 
Published: November 2022

Abstract
In this letter, we search for the signal of primordial black holes (PBHs) by correlating the γ-ray emissions in the MeV energy band produced by the Hawking evaporation and the lensing effect of the cosmic microwave background (CMB). We use the conservative case of the astrophysical model as much as possible in the calculations, since the potential astrophysical origins dominate the observed emission in the MeV energy band. By carefully discussing the appropriate energy bands corresponding to different PBH masses, it is worth expecting a tight constraint on the fraction of the Schwarzschild PBHs in the mass range of 1016–5 × 1017 g by simulations of the sensitivity of the future CMB-S4 project and the γ-ray telescope e-ASTROGAM. Furthermore, we also consider the PBH model with spins and find that the constraining ability of the PBH fraction from the correlation between CMB lensing and γ-ray emissions can be improved by another order of magnitude, which could importantly fill the gaps with PBH fraction limits in the mass range of 5 × 1017–2 × 1018 g.
Effects of Impact and Target Parameters on the Results of a Kinetic Impactor: Predictions for the Double Asteroid Redirection Test (DART) Mission
Authors: Stickle Angela M. , DeCoster Mallory E. , Burger Christoph , Caldwell Wendy K. , Graninger Dawn , Kumamoto Kathryn M. , Luther Robert , Ormö Jens , Raducan Sabina , Rainey Emma , Schäfer Christoph M. , Walker James D. , Zhang Yun , Michel Patrick , Michael Owen J. , Barnouin Olivier , Cheng Andy F. , Chocron Sidney , Collins Gareth S. , Davison Thomas M. , Dotto Elisabetta , Ferrari Fabio , Isabel Herreros M. , Ivanovski Stavro L. , Jutzi Martin , Lucchetti Alice , Martellato Elena , Pajola Maurizio , Plesko Cathy S. , Bruck Syal Megan , Schwartz Stephen R. , Sunshine Jessica M. , Wünnemann Kai 
Published: November 2022

Abstract
The Double Asteroid Redirection Test (DART) spacecraft will impact into the asteroid Dimorphos on 2022 September 26 as a test of the kinetic impactor technique for planetary defense. The efficiency of the deflection following a kinetic impactor can be represented using the momentum enhancement factor, β, which is dependent on factors such as impact geometry and the specific target material properties. Currently, very little is known about Dimorphos and its material properties, which introduces uncertainty in the results of the deflection efficiency observables, including crater formation, ejecta distribution, and β. The DART Impact Modeling Working Group (IWG) is responsible for using impact simulations to better understand the results of the DART impact. Pre-impact simulation studies also provide considerable insight into how different properties and impact scenarios affect momentum enhancement following a kinetic impact. This insight provides a basis for predicting the effects of the DART impact and the first understanding of how to interpret results following the encounter. Following the DART impact, the knowledge gained from these studies will inform the initial simulations that will recreate the impact conditions, including providing estimates for potential material properties of Dimorphos and β resulting from DART’s impact. This paper summarizes, at a high level, what has been learned from the IWG simulations and experiments in preparation for the DART impact. While unknown, estimates for reasonable potential material properties of Dimorphos provide predictions for β of 1–5, depending on end-member cases in the strength regime.
Molecular typing of dengue virus in Mizoram, Northeast India
Authors: Sailo Christine Vanlalbiakdiki , Ghatak Souvik , Sarathbabu Subbarayan , Bariha Girija Shankar , Majumder Ayan , Singh Abhinav , Lalremruata Ralte , Zomawia Eric , Lalrinpuia Benjamin , Lalfak zuali  , Zothanzama John , Senthil Kumar Nachimuthu 
Published: November 2022

Introduction: Dengue is an emerging vector-borne public health threat and characterization at the molecular level is important for proper management of the disease. The aim of the study is to examine the diversity of the dengue viral serotypes from a hilly mountainous region of Northeast India.
Methodology: Thirty-six blood samples that were positive for dengue virus IgM antibodies identified by the enzyme-linked immunosorbent assay (ELISA) method were collected and quantified for the IL6 gene expression by using reverse transcriptase polymerase chain reaction (RT-PCR).
Results: All the patients had dengue hemorrhagic fever (DHF); 12 samples had a monotypic infection and 14 samples had dual infection with various dengue virus (DENV) serotypes; one sample had triple infection with DENV-1, DENV-2, and DENV-3.
Conclusions: This study identified DENV-1 as the major serotype in the state of Mizoram and it is the first report on the molecular typing of the dengue virus from the hilly mountainous state located in the Indo-Burma region bordering Myanmar and Bangladesh.