bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qualitative study to characterize patient experience and relevance of patient-reported outcome measures for patients with metastatic synovial sarcoma
Authors: Eliason Laurie , Grant Laura , Francis Anya , Cardellino Anna , Culver Ken , Chawla Sant P. , Arbuckle Rob , Pokras Shibani 
Published: May 2022

Abstract
Background
The outlook for patients with metastatic synovial sarcoma (mSS) is poor. Better understanding of patient experience in this setting, beyond clinical measures, may guide improvements in management. Validated patient-reported outcome (PRO) instruments specific to many types of cancer exist, but for rare cancers this is often not the case.

Methods
This study aimed to characterize patient experiences of symptoms and impacts of mSS and evaluate the content validity and relevance of the novel European Organization for Research and Treatment of Cancer Item Library 31 (EORTC IL31) Disease Symptoms PRO tool assessing synovial sarcoma symptoms. This tool comprises items from preexisting, validated cancer-specific PRO instruments from the EORTC Item Library. It was developed as an mSS-specific add-on to the EORTC Quality of Life Questionnaire Core 30 (QLQ-C30), which evaluates general cancer and treatment-related symptoms and functioning. This was a non-interventional, qualitative interview study involving semi-structured, concept elicitation (CE) and cognitive debriefing (CD) telephone interviews in adults with mSS. CE explored symptoms and their impact on functioning and quality of life; CD assessed participant understanding and relevance of the PRO tools.

Results
Among the 8 participants, the most common disease-related symptoms reported during CE were fatigue and pain, while shortness of breath was one of the most bothersome. The greatest negative impacts of mSS occurred in domains of physical functioning and sleep. Key treatment priorities for patients were to improve disrupted sleep and ability to undertake strenuous activities.

Conclusions
The interviews showed that, when used together, the EORTC IL31 and EORTC QLQ-C30 covered symptoms and impacts of most relevance and importance to patients with mSS, with no notable gaps and good conceptual coverage. This study therefore supports the content validity of 2 tools in mSS, advocating their use in clinical trials to assess treatment impact on PRO measures of importance to these patients.
Comparison of clinical outcomes following osteochondral allograft transplantation for osteochondral versus chondral defects in the knee
Authors: Matthews John Reza , Brutico Joseph , Heard Jeremy , Chauhan Kashyap , Tucker Bradford , Freedman Kevin Blake 
Published: May 2022

Abstract
Purpose
Osteochondral allograft (OCA) transplantation is a restorative technique for addressing articular cartilage defects by transferring mature viable chondrocytes with subchondral bone into size-matched lesions. The purpose of this study was to compare differences in clinical and functional outcomes in patients treated with OCA for osteochondral defects compared with isolated chondral pathology.

Methods
A retrospective review identified patients who underwent OCA transplantation and grouped them into osteochondral or isolated chondral pathology. Demographic data, surgical history, lesion characteristics, complications, and rate of subsequent surgery were reviewed. The review included 86 patients (24 osteochondral, 62 chondral) with a mean follow-up of 5.4 ± 1.4 years. Outcome measures included the Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS, JR.), International Knee Documentation Committee (IKDC), and Short Form Health Survey (SF-12) physical scores. Failure was defined to include revision OCA, graft removal, conversion to ACI, or conversion to arthroplasty.

Results
The average age at surgery was 32.3 and 37.3 years for the osteochondral and chondral groups, respectively (P = 0.056). The medial femoral condyle was the most common defect location in both groups. P < 0.05 was considered statistically significant. Patients with osteochondral pathology had significantly greater KOOS JR., IKDC, and SF-12 scores (P < 0.05), and fewer failures were reported in the osteochondral group (8.3% versus 32.3%, P = 0.045). When controlling for age, sex, laterality, BMI, and presence of a concomitant procedure, patients with osteochondral pathology were found to have better KOOS and IKDC scores, but there was no difference in SF12 scores or rates of failure between groups.

Conclusion
The findings of this study indicate that patients undergoing OCA for osteochondral defects may have greater functional outcomes and similar failure rates compared with OCA transplantation for isolated chondral pathology.
Platelet-rich plasma injection in the treatment of patellar tendinopathy: a systematic review and meta-analysis
Authors: Barman Apurba , Sinha Mithilesh K. , Sahoo Jagannatha , Jena Debasish , Patel Vikas , Patel Suman , Bhattacharjee Souvik , Baral Debanjan 
Published: May 2022

Abstract
Purpose
The objective of the study was to assess the efficacy of autologous platelet-rich plasma (PRP) injections in the treatment of patellar tendinopathy.

Methods
The PubMed, MEDLINE, EMBASE, CINAHL, and Cochrane Central Register of Controlled Trials databases were searched for clinical trials which compared PRP injection with other ‘active treatment’ interventions (‘Non-PRP’ injection and ‘No-injection’ treatments) or ‘No-active treatment’ interventions. Randomized and non-randomized clinical trials that had been published up to 15 November 2021, were included in the meta-analysis. The primary outcome, pain relief, was measured on a ‘visual analog scale.’ Secondary outcomes were knee functional activities and quality of life (QoL). The PRISMA guidelines were followed throughout the study.

Results
Eight comparative studies were identified for inclusion in the meta-analysis. Assessment of these studies revealed that there were no significant differences in pain relief, functional outcomes, and QoL in the short, medium, and long term between PRP injection and Non-PRP injection interventions. Similarly, comparison of PRP injection to the No-active treatment intervention showed no differences in short- and medium-term pain relief. However, when PRP injection was compared to the No-injection treatment intervention extracorporeal shock wave therapy (ECWT), the former was found to be more effective in terms of pain relief in the medium term (mean difference [MD] − 1.50; 95% confidence interval [CI] − 2.72 to − 0.28) and long term (MD − 1.70; 95% CI, − 2.90 to − 0.50) and functional outcomes in the medium term (MD 13.0; 95% CI 3.01–22.99) and long term (MD 13.70; 95% CI 4.62–22.78).

Conclusions
In terms of pain relief and functional outcomes, the PRP injection did not provide significantly greater clinical benefit than Non-PRP injections in the treatment of patellar tendinopathy. However, in comparison with ESWT, there was a significant benefit in favor of PRP injection.
Assessment of efficacy and safety of two Egyptian protocols for treatment-experienced HCV patients: an observational study
Authors: Hagag Radwa Samir , Fakhry Morkoss Medhat , Ahmed Ossama Ashraf , Abdalgeleel Shaimaa Abdalaleem , Radwan Mahasen Aly , Naguib Gina Gamal 
Published: May 2022

AbstractBackgroundThe devastating adverse effects of interferon (IFN) for the treatment of hepatitis C virus (HCV) lead to the emerging of direct acting antiviral agents (DAAs). This investigation was undertaken to assess safety and efficacy of two Egyptian DAA protocols for HCV: sofosbuvir (SOF)/daclatasvir (DCV)/simeprevir (SMV)/ribavirin (RBV) and sofosbuvir (SOF)/ombitasvir (OMB)/paritaprevir (PTV)/ritonavir (RTV)/RBV for 12 weeks in treatment-experienced HCV Egyptian patients.MethodsIt is a retrospective study where 139 patients, out of 400 patients, were divided according to their documented treatment protocol into two groups (Gp1: SOF/DCV/SMV/RBV and Gp2: SOF/PTV/OMB/RTV/RBV). All patients’ physical examination, disease history, laboratory baseline, and end of treatment data were collected from their profiles, evaluated and compared.ResultsGp1 and Gp2 regimens had achieved sustained virologic response rates (SVR12) of 96.6% and 95.1%, respectively. Hemoglobin, ALT, and AST had decreased significantly (P< 0.05) in the two groups. Total bilirubin level had increased significantly in Gp1 and Gp2 (P = 0.002 and < 0.001, respectively). Creatinine level had increased significantly (P = 0.002) in Gp1 at end of treatment, while Gp2 remained unchanged. Headache and fatigue were the most common side effects in both protocols.ConclusionsSOF/DCV/SMV/RBV and SOF/PTV/OMB/RTV/RBV regimens achieved high similar efficacy in Egyptian treatment-experienced HCV patients. Even though the outcome was with tolerable side effects, a better treatment regimen was recommended to abate these side effects for the welfare of Egyptian HCV patients.
Development of a questionnaire to measure the knowledge, expectations, and challenges of parents of children with cochlear implants
Authors: Salah Norhan , Osman Dalia Mostafa , Safwat Rasha , Farag Heba Mahmoud 
Published: May 2022

AbstractObjectivesWhen children are diagnosed with loss of hearing, different aspects will influence the parents’ decision-making process of cochlear implantation. Little information is available for coping experience and challenges associated with parenting cochlear implanted children. The objective of this work was to study parental knowledge of parental expectations versus experiences about CI children and to explore the challenges they might face.Material and methodsParticipants were parents of 50 Egyptian children with CI (28 males and 22 females). The children’s ages ranged from 5 to 8 years with a mean age of 6.55 years. An Arabic questionnaire was designed to evaluate parental perspectives and challenges during the CI procedure.ResultsMost of the parents were satisfied with the amount of knowledge they received before implantation. Nearly half of parents (48%) received their knowledge about CI from the experience of others. Parents who d a sufficient awareness of the prerequisites of the protocol of CI in the general national health insurance were (48%). Most of the parents had challenges with a length of the CI procedure, expensive spare parts, and the cost of language therapy. Parents showed high expectations regarding academic achievements. Parental expectations regarding communication ability and social skills were met. Parents were most satisfied with the improved wellbeing and future life skills of their children.ConclusionsThis study declares that the parental questionnaire is an important instrument that gives insight into the knowledge, expectations, and challenges of parents of children with cochlear implants in order to achieve a successful consequence following implantation.
Fast 2.5D and 3D inversion of transient electromagnetic surveys using the octree-based finite-element method
Authors: Xiao Longying , Fiandaca Gianluca , Zhang Bo , Auken Esben , Christiansen Anders Vest 
Published: May 2022

Two efficient implementations of 3D and 2.5D modeling and inversion are presented to be applicable to large-scale transient electromagnetic (TEM) method explorations. The key novel features are (1) forward response and Jacobian calculations are implemented using the octree-based finite-element method, (2) a mirror approach is used to build a 2.5D inversion scheme for further efficiency, and (3) a flexible link between the forward mesh and inversion model is applied on 3D and 2.5D schemes based on the voxel formulation. We compare the performance of the new implementations with 3D modeling using tetrahedral meshes, with respect to speed and memory requirements. The 3D octree algorithm requires less than 1/3 of the computational time compared with a 3D tetrahedral scheme for equivalent accuracy. The 2.5D octree algorithm further speeds up the process by reducing the computational time by another factor of two. The inversion uses the Levenberg-Marquart approach minimizing the least-squares criterion of the objective function. We determine the utility of our inversion approach on a synthetic example and a field example. In the synthetic example, the 3D octree inversion result finds superior resolution of a 3D anomaly compared with a 1D result, whereas the 2.5D inversion result is, expectedly, between the 1D and 3D results, but with favorable computational expenses compared with the full 3D solution. The field data set contains 200 soundings, and we perform a 3D inversion on the full survey. A 24-sounding section is then selected for the 2.5D inversion. The 2.5D inversion result finds resistivity features similar to the 3D inversion result at the selected profile. Hence, we conclude that the presented implementations are capable of handling relatively large TEM surveys on modern computational platforms. This could be smaller subsets of production-size surveys where 2D and 3D effects are pronounced.
Drone-mounted ground-penetrating radar surveying: Flight-height considerations for diffraction-based velocity analysis
Authors: Booth Adam D. , Koylass Tiffany M. 
Published: May 2022

Recent studies highlight the potential of the drone platform for ground-penetrating radar (GPR) surveying. Most guidance for optimizing drone flight heights is based on maximizing the image quality of target responses, but no study yet considers the impact on diffraction traveltimes. Strong GPR velocity contrasts across the air-ground interface introduce significant refraction effects that distort diffraction hyperbolas and introduce errors into diffraction-based velocity analysis. The severity of these errors is explored with synthetic GPR responses, using ray- and finite-difference approaches, and a field GPR data set acquired over a sequence of diffracting features buried up to 1 m depth. Throughout, GPR antennas with 1000 MHz center frequency are raised from the ground to heights <0.9 m (i.e., 0–3 times the wavelength in air). Velocity estimates are within +10% of modeled values (spanning from 0.07 to 0.13 m/ns) if the antenna height is within 1/2 wavelength in air above the ground surface. Greater heights reduce diffraction curvature, damaging velocity precision, and masking diffractions against a background of subhorizontal reflectivity. Field data highlight further problems of the drone-based platform, with data dominated by reverberations in the air gap and reduced spatial resolution of wavelets at target depth. We suggest that a drone-based platform is unsuitable for diffraction-based velocity analysis, and any future drone surveys are benchmarked against ground-coupled data sets.
Acute Postoperative Seizures and Engel Class Outcome at 1 Year Postselective Laser Amygdalohippocampal Ablation for Mesial Temporal Lobe Epilepsy
Authors: Barkley Ariana S. , Sullivan Liam T. , Gibson Alec W. , Zalewski Kody , Mac Donald Christine L. , Barber Jason K. , Hakimian Shahin , Ko Andrew L. , Ojemann Jeffrey G. , Hauptman Jason S. 
Published: May 2022

BACKGROUND:MRI-guided laser interstitial thermal therapy (MRgLITT) for mesial temporal lobe epilepsy is a safe, minimally invasive alternative to traditional surgical approaches. Prognostic factors associated with efficacy are debated; preoperative epilepsy duration and semiology seem to be important variables.OBJECTIVE:To determine whether acute postoperative seizure (APOS) after MRgLITT for mesial temporal lobe epilepsy is associated with seizure freedom/Engel class outcome at 1 year.METHODS:A single-institution retrospective study including adults undergoing first time MRgLITT for mesial temporal lobe epilepsy (2010-2019) with ≥1-year follow-up. Preoperative data included sex, epilepsy duration, number of antiepileptics attempted, weekly seizure frequency, seizure semiology, and radiographically verified anatomic lesion at seizure focus. Postoperative data included clinical detection of APOS within 7 days postoperatively, and immediate amygdala, hippocampal, entorhinal, and parahippocampal residual volumes determined using quantitative imaging postprocessing. Primary outcome was seizure freedom/Engel classification 1 year postoperatively.RESULTS:Of 116 patients, 53% (n = 61) were female, with an average epilepsy duration of 21 (±14) years, average 6 failed antiepileptics (±3), and weekly seizure frequency of 5. APOS was associated with worse Engel class (P= .010), conferring 6.3 times greater odds of having no improvement vs achieving seizure freedom at 1 year. Residual amygdala, hippocampal, entorhinal, and parahippocampal volumes were not statistically significant prognostic factors.CONCLUSION:APOS was associated with a lower chance of seizure freedom at 1 year post-MRgLITT for mesial temporal lobe epilepsy. Amygdala, hippocampal, entorhinal, and parahippocampal residual volumes after ablation were not significant prognostic factors.
Why did he say that? Teaching physicians-in-training how to recognize hidden emotions in end-of-life prognosis conversations: an autoethnography
Authors: Stonestreet John 
Published: May 2022

Background: Intuitively accessible via WhyDidHeSayThat.com, this article begins with two unconscionable end-of-life prognosis-related quotes from best-selling physician-author, Atul Gawande, and an unnamed doctor, asking: “Why did he say that?” The article then proceeds to answer this question by showing how physicians’ most common end-of-life communication blunders are rooted in their unexplored emotions. Healthcare’s only widespread conversation analysis training focused on examining the role of hidden emotions in influencing the flow of conversation is found in Spiritual Care’s “Verbatim” education modules. While the need for physicians’ emotional self-awareness for improved end-of-life communication has been identified in the literature, no one has explored how this need might be met by custom-tailoring Spiritual Care’s “Verbatim” education modules for physicians-in-training. Methods: This article utilizes the qualitative research method of autoethnography to grant physicians access to the content and power of Spiritual Care’s “Verbatim” education modules for conversation analysis and emotional intelligence.  Results: Using a profound personal example from the author’s firsthand experience of the suggested training tool, the “Verbatim” module is shown to grant revelatory self-knowledge and invaluable emotional intelligence. The same model then illuminates the physician cases. Conclusion: Spiritual Care’s “Verbatim” education modules address universal issues of clinical communication and emotional self-awareness that are applicable to physician-patient/family conversations surrounding end-of-life decision-making. Customizing these conversation analysis modules for physicians-in-training may help to address physicians’ emotionally-triggered conversational miscues in end-of-life prognosis communication. Existing programs for complementary end-of-life communication training are noted, and it is claimed that a combination of each of these models, together with the proposed module, may be ideal. It is also admitted that no form of education or training can ensure ethical communication. Therefore the ultimate solution is to supplement communication training with real-time, third-party support and accountability. This can be achieved by the "Doctor Body Cam" intervention protocol, accessible via DoctorBodyCam.com.
A comparison of the World Health Organisation's HEAT model results using a non-linear physical activity dose response function with results from the existing tool
Authors: Smith Robert , Thomas Chloe , Squires Hazel , Goyder Elizabeth 
Published: May 2022

Introduction: The WHO-Europe’s Health Economic Assessment Tool is a tool used to estimate the costs and benefits of changes in walking and cycling. Due to data limitations the tool’s physical activity module assumes a linear dose response relationship be-tween physical activity and mortality. Methods: This study estimates baseline population physical activity distributions for 44 countries included in the HEAT. It then compares, for three different scenarios, the results generated by the current method, using a linear dose-response relationship, with results generated using a non-linear dose-response relationship. Results: The study finds that estimated deaths averted are relatively higher (lower) using the non-linear effect in countries with less (more) active populations. This difference is largest for interventions which affect the activity levels of the least active the most. Since more active populations, e.g. in Eastern Europe, also tend to have lower Value of a Statistical Life estimates the net monetary benefit estimated by the scenarios are much higher in western-Europe than eastern-Europe. Conclusions: Using a non-linear dose response function results in materially different estimates where populations are particularly inactive or particularly active. Estimating base-line distributions is possible with limited additional data requirements, although the method has yet to be validated. Given the significant role of the physical activity module within the HEAT tool it is likely that in the evaluation of many interventions the monetary benefit estimates will be sensitive to the choice of the physical activity dose response function.
The Ex Ante Likelihood of Bubbles
Authors: Chinco Alex 
Published: May 2022

The limits of arbitrage explain how a speculative bubble is sustained; they do not explain how likely one is to occur. To do that, you need a theory about the thing that sporadically causes arbitrageur constraints to bind. I propose a first such theory, which is based on social interactions between speculators. The theory says that bubbles should be more likely in assets where increases in past returns make excited-speculators relatively more persuasive to their peers. I empirically verify this ex ante prediction about bubble likelihoods and show that it is robust to some ex post disagreement about bubble definitions. This paper was accepted by Victoria Ivashina, finance. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2022.4351 .