bluuebunny/crossref_metadata_2025_split huggingface dataset:
The New Technique in Hemorrhoid Disease: A Combination of Laser Hemorrhoidoplasty and Ferguson Hemorrhoidectomy
Authors: Yanar Fatih , Abbasov Aykhan , Ilhan Burak , Ozcınar Beyza , Yanar Hakan 
Published: August 2022

Abstract
Purpose: This study aimed to evaluate the early and long-term results of the three surgical methods (Ferguson hemorrhoidectomy, laser hemorrhoidoplasty, and combined method) of hemorrhoidal disease. Methods: Between January 2018 and January 2020, 154 consecutive patients diagnosed with symptomatic grade II-III hemorrhoid disease were treated with Ferguson hemorrhoidectomy (FH group), laser hemorrhoidoplasty (LHP group), or combined (FH + LHP group) method. Patients were evaluated in terms of duration of surgery, recovery time of symptoms, postoperative pain, early and late complications, and recurrence. Results: Postoperative pain scores on the 6th, 12th, 24th hours, and 7th day were significantly lower in the LHP group compared to other groups (p <0.001). Upon development of postoperative perianal thrombosis in 2 patients of the LHP group, one patient underwent thrombectomy and the other patient underwent medical treatment. In the FH group, reoperation and hemostasis are done for bleeding on the postoperative 6th day in 1 patient, and a foley catheter was applied due to urinary retention in 1 patient. Two anal fissures were seen in postoperative one month in the FH group and recovered with medical treatment and sitz bath. There were two hemorrhoid disease recurrences the median follow-up period of 24 (12-36) months in the LHP group only.Conclusion: In patients with multiple hemorrhoid packages with both grade 2 and also grade 3 disease, the combined method can be better used safely and effectively, despite relatively higher pain scores, and prolonged operation time compared to the LHP method but considering rare complications and recurrences.
Predictive factors for Roux stasis syndrome after distal gastrectomy with Roux-en-Y reconstruction in gastric cancer patients: A retrospective comparative cohort study
Authors: Meng Yan , Ma Yanpeng , Qu Ruize , Ma Junren , Lin Hsinyi , Lu Siyi , Fu Wei , Zhou Xin 
Published: August 2022

Abstract
Background: Roux-en-Y (R-Y) reconstruction after distal gastrectomy in gastric cancer patients can cause Roux stasis syndrome (RSS), the pathogenic mechanism of which is unclear. This study retrospectively evaluated the risk factors for RSS.Material and methods: Patients who were pathologically diagnosed with gastric cancer and underwent distal gastrectomy with R-Y reconstruction between March 2014 and March 2021 were retrospectively analyzed. RSS occurrence was evaluated and examined for correlations with demographic and clinicopathological data. A nomogram was built using “R” package.Results: RSS was observed in 20/220 patients (9.1%), and there was a significant difference between males and females (11.9% vs. 3.9%, p = 0.049). The incidence of RSS tended to be higher in underweight (body mass index (BMI) < 18.5 kg/m2) and obese (BMI ≥ 28.0 kg/m2) patients (p = 0.043). The rates of smoking and nerve invasion were higher in patients with RSS, but statistical significance was not reached. There were no significant differences in other factors. A nomogram was built in which sex, BMI group, nerve invasion and smoking were incorporated to predict RSS (AUC = 0.71).Conclusions: Both male sex and a polarized BMI are independent risk factors for RSS after distal gastrectomy with R-Y reconstruction in gastric cancer patients. A nomogram including sex, BMI group, nerve invasion and smoking can predict RSS occurrence.Trial registration number:NCT04919577 (ClinicalTrials.gov)
Bicuspid Aortic Valve Disease : a 10 Year Latin-american Experience
Authors: Gómez Paula Torres , Rey Carlos , Correa Juan Rafael , Rios Edgar 
Published: August 2022

Abstract
BackgroundBicuspid aortic valve is one of the most common congenital heart malformations affecting 2% of the population. There is a gap in the literature regarding the Latin-American population, the aim of this study is to analyze the demographic, clinical characteristics and the surgical outcomes of patients with bicuspid aortic valve (BAV) with a 1,5 and 10 year follow-up in a single center.MethodsWe performed a retrospective review of a prospectively collected database. All patients that underwent aortic-valve related procedures with bicuspid aortic valve finding between 2011-2021 were included. Comparison between groups were performed using paired t-test or Mann Whitney-Wilcoxon when appropriate. Statistically significant value was accepted if < 0.05. Results: 82 patients were included. Male patients constituted 71.95% of the population. Median age was 58 years (IQR 47;65). Type 1 BAV were the most common finding (85.19%). Aortic stenosis was the most common clinical feature in 64.64% of the cases. Coronary artery disease and smoking history are related with decreased left ventricular function with statistically significant value (p 0.02 - 0.03 respectively). Mortality rate was 2.44. Overall survival rate after 1-5 and 10 years was 97.56%, 96.42%, and 80.5% respectively.Conclusions: Patients with associated coronary artery disease and smoking history should be considered high risk patients due to the relationship with decreased left ventricular function even with an asymptomatic course. Further prospective studies are needed to prove our results.
Origin of rice gametophytic cytoplasmic male sterility genes in Chinese populations of Oryza rufipogon through sequence features of B-atp6-orfH79
Authors: Zhang Xuemei , Chen Shuying , Zhao Zixian , Zhao Yinhe , Ma Cunqiang , Liu Yating 
Published: August 2022

Abstract
Background: The cytoplasmic male sterility (CMS) of rice is caused by chimeric mitochondrial DNA (mtDNA) that is maternally inherited in the majority of multicellular organisms. Wild rice (Oryza rufipogon Griff.) has been regarded as an ancestral progenitor of Asian rice (Oryza sativa). To identify additional CMS sources, and explore the origin of gametophytic CMS gene, a total of 427 individuals with 17 representative populations of O. rufipogon were collected in from Dongxiang of Jiangxi Province to Sanya of Hainan Province, China, for the PCR amplification of atp6, orfH79 and B-atp6-orfH79, respectively.
Results: Among 17 populations, the B-atp6-orfH79 and its variants (B-atp6-GSV) were detected in five populations (i.e. HK, GZ, PS, TL and YJ) through PCR amplification, which were divided into three haplotypes, i.e., BH1, BH2, and BH3. The BH2 haplotype was identical to B-atp6-orfH79, while the BH1 and BH3 were the novel haplotypes of B-atp6-orfH79. Combined with the high-homology sequences in GenBank, a total of 18 haplotypes have been revealed, which only could be divided into 10 haplotypes in orfH79 and its variants (GSV) section.thatbelong to 3 species (i.e. O. rufipogon, Oryza nivara and Oryza sativa) Enough haplotypes clearly demonstrate the structural characteristics of the B-atp6-orfH79 as follows: Except for the conserved sequence (671 bp) composed of B-atp6 (619 bp) and the downstream followed the B-atp6 (52 bp, DS), and GSV sequence, a rich variable sequence (VS, 176 bp) lies between the DS and GSV with 5 insertion or deletion and more than 30 single nucleotide polymorphism. Maximum likelihood analysis showed that 18 haplotypes formed three clades with high support rate. The hierarchical analysis of molecular variance (AMOVA) indicated the occurrence of variation among all populations (FST = 1; P < 0.001), which implied that the chimeric structure occurred independently. All 17 haplotypes of the orfH79 was statisticsed based on our results and the existing references, which belong to 6 species, but their genetic relationship can not be reflected through systematic analysis. 7 existed single nucleotide polymorphism in GSV section can be translated into 11 various amino acid sequences.
Conclusions: In this study, the relevant populations provide diverse CMS primary sources. B-atp6 and the GSV simultaneous existence in the plant. The sequence characteristics of B-atp6-orfH79 and Maximum Likelihood analysis indicated the chimerise occur independently with consistent chimeric sites, which might help to explore the origin of rice gametophytic CMS genes in O. rufipogon.
WITHDRAWN: Development and validation of a nomogram for predicting metachronous peritoneal metastasis in colorectal cancer: a retrospective study
Authors: Ban Bo , Shang An , Shi Jian 
Published: August 2022

Abstract
Background: The present study aimed to establish and validate a nomogram model to predict the occurrence of metachronous peritoneal metastasis (m-PM) in colorectal cancer (CRC) within 3 years after surgery. Method: The clinical datum of 965 patients were enrolled in this study from Second Hospital of Jilin University, between January 1, 2014 and January 31, 2019. The patients were randomly divided into training and validation cohorts at a ratio of 2:1. The least absolute shrinkage and selection operator (LASSO) regression was performed to identify the variables with nonzero coefficients to predict the risk of m-PM. Multivariate logistic regression was used to verify the selected variables and to develop the predictive nomogram model. Harrell's concordance index (C-index), receiver operating characteristic (ROC) curve, Brier score, and decision curve analysis (DCA) were used to evaluate discrimination, distinctiveness, validity, and clinical utility of this nomogram model. The model was verified internally using bootstrapping method and verified externally using validation cohort.Results: The nomogram included 7 predictors: emergency operation, tumor site, histological type, pathological T stage, CA125, BRAF mutation and MSI status. The model achieved a good prediction accuracy on both the training and validation datasets. The C-index, area under the curve (AUC), and Brier scores were 0.814, 0.814 (95%CI 0.764–0.864), and 0.079, respectively, for the training cohort were 0.812, 0.812 (95%CI 0.732–0.893) and 0.087, respectively. DCA showed that when the threshold probability was between 0.01 and 0.75, using this model to predict m-PM could achieve a net clinical benefit.Conclusion: we have established and validated a nomogram model to predict m-PM in patients undergoing curative surgery, which shows good discrimination and high accuracy.Trial registration: The study was approved by Ethics Committee of the Second Hospital of Jilin University (Approval No.2021003) on January 19th.
Dopamine D 2/3 receptor availabilities in striatal and extrastriatal regions of the adult human brain: Comparison of four methods of analysis
Authors: Khodaii Javad , Nomura Yoshiyuki , Chang Natalie Hong Siu , Wong Dean F. , Møller Arne , Gjedde Albert 
Published: August 2022

AbstractBackground:Values of binding potentials (BPND) of dopamine D2/3receptors differ in different regions of the brain, but we do not know with certainty how much of this difference is due either to different receptor numbers, or to different affinities of tracers to the receptors, or to both.Method:We tested the claim that both striatal and extrastriatal dopamine D2/3receptor availabilities vary with age in vivo in humans by determining the values ofBPNDof the specific radioligand [11C]raclopride. We determined values ofBPNDin striatal and extrastriatal volumes-of-interest (VOI) with the same specific receptor radioligand.Results:We estimated values ofBPNDin individual voxels of brains of healthy volunteers in vivo, and we obtained regional averages of VOI by dynamic positron emission tomography (PET). We calculated average values ofBPNDin caudate nucleus and putamen of striatum, and in frontal, occipital, parietal, and temporal cortices of the forebrain, by means of four methods, including the ERLiBiRD (Estimation of Reversible Ligand Binding and Receptor Density) method, the tissue reference methods of Logan and Logan-Ichise, respectively, and the SRTM (Simplified Reference Tissue Method). Voxelwise generation of parametric maps of values ofBPNDused the multi-linear regression version of SRTM.Conclusions:The estimates ofBPNDdeclined significantly with age in both striatal and extrastriatal regions, as determined by all four methods, with the greatest decline observed in posterior (occipital and parietal) cortices (14% per decade) and the lowest decline in caudate nucleus (3% per decade).
Treadmill exercise improves brain energy metabolism, motor, and cognitive functions in Hypoxic Ischemic Encephalopathy mice model
Authors: Pei Feifei , Gandi Fred , Wang Yuan , Li Haoyue , Du Shijia , Cui Susu , Fu Jia , Chang Cheng 
Published: August 2022

Abstract
More evidence shows that the brain energy demands are enormous. This study aimed to examine the metabolism changes in the brain of hypoxic ischemic encephalopathy (HIE) mice model and to evaluate how treadmill exercise enhances brain metabolism. We used unilateral carotid common artery ligation mice model to simulate the clinical HIE patients. Several behavior tests were used to evaluate the motor and cognitive function impairment, western blot and immunofluorescence were used to assess the metabolism related protein changes in the different groups. Meanwhile, the HIE mice models were randomly divided into exercise training group (HIE-T) which were subjected to four weeks of treadmill exercise training and non-exercise training group (HIE-NT). The results revealed that there was decreased expression of glucose transporters GLUTs in HIE and an enhanced expression of monocarboxylate transporters MCTs, which is an important part of energy metabolism adaptation. After the period of treadmill exercise training, the expression of GLUT1 as well as MCT1 increased in the motor cortex of HIE mice model. Moreover, the mitochondrial cristae and edges were clear and intact under Transmission electron microscope compared with HIE-NT group. This suggests that increased brain energy attributed to treadmill exercise training shows promising therapeutic potential for HIE.
WITHDRAWN: Flexible Uretero-Renoscopy Versus Mini-Percutaneous Nephrolithotomy for Treatment of Renal Stones 2 Cm or Less; A Randomised, Comparative Study
Authors: Darwish Amr E. , Abdelmoniem Alaa E. , Ahmed Abdelfatah I. , Hamdy Seif M. , Abolella Hassan A. , Reda Ahmed 
Published: August 2022

Abstract
Purpose: To compare the outcomes of treatment of renal stones of 2 cm or less with either fURS or mPCNL.Methods: This was a prospective, randomized, comparative study conducted between January 2019 and July 2021 at three tertiary care Urology centers. Inclusion criteria were adult patients with renal stone(s) ≤ 2cm with inappropriateness or failure of extracorporeal shock-wave lithotripsy. The two treatment groups were mPCNL and fURS. Mini-percutaneous nephrolithotomy was done in the prone position under fluoroscopic guidance using a 12-Fr., rigid Nephroscope with the track dilated up to 18 Fr. The study assessed two primary outcomes: (1) initial success rate, which meant absence of CSRF (> 2mm) at the level of KUB and ultrasound on the 1st post-operative day; (2) complications, which were reported according to the Modified Clavien-Dindo classification system. Secondary outcomes included final success rate, which meant absence of CSRF at the level of NCCT on the 90th post-operative day; operative time; auxiliary procedure and blood transfusion rates; haemoglobin drop; and hospital stay.Results: One hundred eighteen procedures were analysed (59 in each group). Initial success rate of mPCNL (93%) was significantly higher than fURS (70%). Complications occurred more frequently with mPCNL (44.1% versus 18.6%, respectively). Final success rate, operative time and hospital stay were comparable between the two groups.Conclusion: Mini-percutaneous nephrolithotomy is more effective than fURS as a rapid, single-step treatment for renal stones due to its higher first-day success rate and lower auxiliary procedure rate. However, it results in significantly higher morbidity than fURS.
An Experimental Study of the Size Effect’s Impact on Consolidation Behaviors of Dredged Silt
Authors: Hu Ronghua , Zhang Ming , Wang Jiaqi 
Published: August 2022

Abstract

The soil sample size of the consolidation test is different from the actual soil, with the differences shown in their compression and permeability properties. This study thus is to investigate the influence of sample size on the consolidation behaviors of dredged silt. In order to investigate the sample size’s impact on consolidation behavior, this study used the automatic air pressure consolidometer to conduct numerous consolidation tests on three kinds of dredged silt samples at different heights in Qianwan, Shenzhen, China. The key findings made the following three significant contributions. (1) The compression curves of samples of different sizes have three stages: small load disturbance, elastic deformation and plastic deformation. The void ratio in the latter two stages decreases with the increase of sample height. (2) The stable strain and compression index of the samples decrease when the samples' height increases. While the sample height has a limited impact on the structural yield stress, its consolidation coefficient decreases significantly with the increase of the sample height. Thus, the size effect’s impact on the consolidation coefficient should be considered. (3) Due to the reason that dredged silt and marine silt have different formation processes, stress history, and material composition, the permeability coefficient of dredged silt is greater than that of marine silt. When the consolidation pressure is lower, the consolidation coefficient of dredged silt is less than that of marine silt. The difference between the consolidation coefficient of the two kinds of silt decreases with the increase of consolidation pressure. The difference of the former is greater than the latter.
Clinical presentation, viral kinetics and management of human monkeypox cases from New Delhi, India 2022
Authors: Rehlan Vineet , Sahay Rima R. , Shete Anita M. , Yadav Pragya D. , Sahoo BL , Patil Deepak Y. , Kumar Suresh , PS Kannan Sabarinath , Dar Lalit , Mohandas Sreelekshmy , Abraham Priya 
Published: August 2022

Abstract

We describe the clinico-demographical, virological follow-up and management of five confirmed Monkeypox cases from New Delhi, India without any international travel history. The viral load kinetics and viral clearance was estimated in oropharyngeal swab (OPS), nasopharyngeal swab (NPS), EDTA blood, serum, urine and various lesion specimens at every fourth day of follow-up ranging from 5–24 post onset day (POD) of illness. All the five cases presented with mild to moderate grade intermittent fever, myalgia and lesions on the genitals, groins, lower limb, trunk and upper limb. Four cases had non-tender firm lymphadenopathy. No secondary complications or sexually transmitted infections were recorded in these cases except for HBV in one case. All the cases were mild and had good recovery. The high viral load was detected at POD 14 in lesion fluid, followed by lesion roof at POD 5, lesion base at POD 14 while urine, OPS and NPS at POD 5. The MPXV DNA was detected from 5 to 24 POD. These Monkeypox cases suggests the under diagnosed monkeypox infection in the community. This emphasizes the need for active surveillance of MPXV in high risk population such as Men having sex with men (MSM) and female sex workers (FSW).
California school lead testing results and the new lead and copper rule
Authors: Kimbrough David Eugene 
Published: August 2022

Abstract
Under the revised lead and copper rule, schools and daycare centers will need to conduct lead and copper sampling. The California Division of Drinking Water required Public Water Systems to assist local schools in testing water for lead between 2017 and 2020. There were 43,803 samples collected from 7,058 schools in 864 school districts. In total, 5.2% of the samples had lead present in concentrations greater than the Detection Limit for Reporting (DLR) of 5 μg/L, and 1.1% of samples had lead concentrations greater than the Action Level (AL) of 15 μg/L. When broken down by counties, these patterns are consistent throughout most of the State. Drinking fountains had significantly lower frequencies of results above the DLR and AL than samples collected from sinks and food preparation areas. Chloride, bicarbonate, and pH appeared to influence the frequency of results above the DLR and AL.
Comparison between Electrical Resistivity Tomography and Geotechnical Field Data for Characterizing Soil Profiles
Authors: Alogla Saleh M. , Alawad Omar M. , Elragi Ahmed F. , Elkholy Sherif , Al-Saadi Gamal A. , Arif Mohammed 
Published: August 2022

Background:
Electrical resistivity tests at a project site could be a valuable economical alternative to typical geotechnical soil exploration and a reliable source of data. In the present study, the soil at a constructed underground water tank site in Qassim Region – Saudi Arabia is investigated using the electrical resistivity testing method.

Objective:
The study aims to compare the results of traditional soil boreholes that were conducted at various stages of the project lifetime with the interpretation of soil resistivity test results.

Methods:
Eight soil boreholes were drilled at the water tank site to capture the nature of soil layers. The electrical resistivity of soil layers at the site is measured and used to investigate the ground subsurface of the project site. The geophysical software, ZondRes2d is utilized to analyze and interpret the collected data.

Results:
Both geotechnical soil boreholes and geophysical electrical resistivity tests revealed similar soil profiles with three main layers comprising of backfill material, clay with expansive nature, and weathered limestone and marl. The results of the electrical resistivity tests are also affirmative of available resistance values of different soils in the literature.

Conclusion:
The study shows that electrical resistivity testing is reliable in capturing the soil nature which presents an attractive tool for preliminary investigation of the soil-related problems of distressed structures.
Neurosensory Assessment of Infraorbital Nerve Injury Following Unilateral Zygomaticomaxillary Complex Fracture – A Prospective Study
Authors: Lakshmi Raj , Chitra A. , Singh Anupam , Pentapati Kalyan C , Gadicherla Srikanth 
Published: August 2022

Background:
This study aimed to assess the difference in the recovery pattern of branches of infraorbital nerve paraesthesia after zygomaticomaxillary complex (ZMC) fracture in both surgically and non-surgically managed patients.

Materials & Methods:
A prospective, observational study involving 31 patients with unilateral ZMC fracture - 15 in the surgical group (Group A) and 16 in the non-surgical group (Group B) was evaluated. These patients were assessed at the time of injury, 3-months follow-up, and 6-months follow-up for the sensory function of the infraorbital nerve. The assessment of paraesthesia by cotton wisp test, light touch monofilament test, and the cold thermal test was subjected to intra-group and inter-group correlation by McNemar test and Fischer's exact test. Repeated Measures ANOVA with post-hoc Bonferroni test for intra-group correlation and independent sample t-test for inter-group correlation were used for two-point discrimination.

Results:
A statistically significant improvement was noted on both 3 and 6 months follow-up in the malar region in group A. Other statistically significant improvements were noted only on 6 months follow-up in the infraorbital region in group A. On the 2-point discrimination test, all the facial regions showed significant improvement in both the groups over 3 months and 6 months of follow-up.

Conclusion:
There was a significant improvement in the infraorbital nerve sensory function following ZMC fracture over 6 months; however, the surgical intervention showed no statistical significance. Further, it can also be concluded that the inferior palpebral branch of the infraorbital nerve shows maximum functional disruption resulting in a higher incidence of paraesthesia in the infraorbital and malar region.