bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase 1b clinical trial of pucotenlimab (HX008), a novel anti-PD-1 monoclonal antibody, combined with gemcitabine and cisplatin in the first-line treatment of metastatic triple-negative breast cancer
Authors: Cao Jun , Wang Biyun , Zhang Jian , Tao Zhonghua , Wang Leiping , Hu Xichun 
Published: August 2022

BackgroundPucotenlimab, also called HX008, is a humanized anti-PD-1 antagonist IgG4 mAb. It blocks programmed cell death protein 1 (PD-1), programmed-death ligand 1 (PD-L1), and programmed death ligand-2 (PD-L2). In the CBCSG 006 trial, gemcitabine plus cisplatin (GP) has shown impressive antitumor activity as first-line therapy for metastatic triple-negative breast cancer (mTNBC). The phase 1b study was conducted to assess the safety and preliminary antitumor activity of pucotenlimab when combined with GP in patients with mTNBC in the first-line setting.MethodsEligible patients with mTNBC with ≥6 months of DFI (disease-free interval) who have never received antitumor therapy for metastatic disease were screened. Participants received pucotenlimab at 3 mg/kg (d1, q3w) plus gemcitabine at 1,250 mg/m2 (d1, 8, q3w) and cisplatin at 75 mg/m2 (d1, q3w). Eligible patients received up to six cycles of pucotenlimab along with GP chemotherapy, while pucotenlimab could be maintained until disease progression or unacceptable toxicity occurred or withdrawal of informed consent. This study was registered in China under registration number CTR20191353.ResultsBetween July 2019 and March 2020, 31 patients were enrolled in this study. The median age was 50 (range 28–68) years. Among 31 patients who were evaluated, 25 (80.6%) experienced objective response and the other six (19.4%) experienced stable disease (SD). As of 4 August, the median progression-free survival (PFS) was 9.0 months (95% CI, 6.2–9.2). The most common grade 3 or 4 treatment-related adverse events included neutropenia (74.1%), anemia (35.5%), thrombocytopenia (32.3%), hypocalcemia (9.7%), hypokalemia (9.7%), and alanine aminotransferase increased (6.5%). There were no treatment-related deaths.ConclusionPucotenlimab plus GP demonstrated promising activity and a manageable safety profile in patients with mTNBC in the first-line setting.
Association of JAK/STAT genetic variants with cutaneous melanoma
Authors: Gomez Gabriela Vilas Bôas , Lourenço Gustavo Jacob , Monteiro Lummy Maria Oliveira , Rocha Rafael Silva , Fernández Kimberly Anne McGrail , Recio Juan Angel , Torricelli Caroline , Coser Lilian Oliveira , Oliveira Alexandre Leite Rodrigues , Carron Juliana , Moraes Aparecida Machado , Lima Carmen Silvia Passos 
Published: August 2022

BackgroundThe Janus-activated kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway regulates cutaneous melanoma (CM) development and progression. The JAK1, JAK2, and STAT3 proteins are encoded by polymorphic genes. This study aimed to verify whether single-nucleotide variants (SNVs) in JAK1 (c.1648+1272G&gt;A, c.991-27C&gt;T), JAK2 (c.-1132G&gt;T, c.-139G&gt;A), and STAT3 (c.*1671T&gt;C, c.-1937C&gt;G) altered the risk, clinicopathological aspects, and survival of CM patients as well as protein activity.MethodsCM patients (N = 248) and controls (N = 274) were enrolled in this study. Genotyping was performed by real-time polymerase chain reaction (PCR), and JAK1, JAK2, and STAT3 expression was assessed by quantitative PCR (qPCR). STAT3 c.-1937C&gt;G SNV was investigated by luciferase, qPCR, western blot, apoptosis, and cell cycle assays in SKMEL-28 cells with CC or GG genotype.ResultsIndividuals with STAT3 c.*1671TT and c.-1937CC genotypes and TC haplotype of both SNVs were under about 2.0-fold increased risk of CM. Specific JAK1, JAK2, and STAT3 combined genotypes were associated with up to 4.0-fold increased risk of CM. Higher luciferase activity [4,013.34 vs. 2,463.32 arbitrary units (AU); p = 0.004], STAT3 expression by qPCR (649.20 vs. 0.03 AU; p = 0.003) and western blot (1.69 vs. 1.16 AU; p = 0.01), and percentage of cells in the S phase of the cell cycle (57.54 vs. 30.73%; p = 0.04) were more frequent in SKMEL-28 with STAT3 c.-1937CC than with GG genotype. CM cell line with CC genotype presented higher STAT3 protein levels than the one with GG genotype (1.93 versus 1.27 AU, p = 0.0027).ConclusionOur data present preliminary evidence that inherited abnormalities in the JAK/STAT pathway can be used to identify individuals at a high risk of CM, who deserve additional attention for tumor prevention and early detection.
Us helping us: The evolution of a peer support group for formerly incarcerated people
Authors: Boles Will , Tatum Thad , Wall Jarrod , Nguyen Lauren , Van Dall Alexandria , Mulhollem Claire , Sacks Anna , Wennerstrom Ashley , Reilly Bruce , Niyogi Anjali 
Published: August 2022

IntroductionPhysical, psychological, and emotional trauma experienced while incarcerated influences subsequent mental health outcomes. Upon release, there is a fragmented landscape of mental health services and many of the existing services do not account for the root causes of challenges faced by formerly incarcerated people (FIP). To address the unmet social, psychological, behavioral, and emotional needs of FIP in Louisiana, the Formerly Incarcerated Peer Support (FIPS) Group developed a twelve-unit curriculum in 2019.MethodsWe detail the evolution, development, and evaluation of the FIPS Group program. Additionally, we describe the community-driven process for developing the curriculum.ResultsThe FIPS Group has grown from informal meetings of a handful of FIP in New Orleans, Louisiana, into a multi-state, interdisciplinary network of more than 150 stakeholders. FIPS Group has developed the only peer support curriculum we are aware of that is designed by FIP, for FIP, and uses the shared experience of incarceration and reentry as its organizing principle. Limitations of the model include the lack of pending evaluation data and challenges with technological proficiency among FIP.ConclusionsThe FIPS Group model may be generalized in a number of settings. Similar approaches may benefit the mental health of the millions of Americans involved in the criminal-legal system.
Investigation of 3-year inpatient TB cases in Zunyi, China: Increased TB burden but improved bacteriological diagnosis
Authors: Chen Ling , Wang Xiaodan , Jia Xudong , Lan Yuanbo , Yi Haibo , Wang Xiaomin , Xu Peng 
Published: August 2022

BackgroundAs one of the top three high tuberculosis (TB) burden countries, China is a country where the overall TB incidence continues to decline. However, due to its large population and area, the increased TB burden exists in regional areas.MethodsThis retrospective study analyzed local inpatient pulmonary TB cases in the Affiliated Hospital of Zunyi Medical University (AHZMU) from January 2016 to December 2018 in a high TB incidence and economically-less-developed area of China. Four methods, acid-fast bacilli stain, culture, Xpert and LAMP, were used to detect Mycobacterium tuberculosis (M.tb), while proportional method and Xpert were used to identify rifampicin-resistant TB (RR-TB). Case number, treatment history, M.tb confirmed TB and rifampicin resistant proportion were analyzed to investigate the local TB epidemic.ResultsTotal 3,910 local inpatient cases with pulmonary TB were admitted to AHZMU during this study period. The annual numbers of total TB cases increased 26.4% (from 1,173 to 1,483), while new cases increased 29.6% (from 936 to 1,213) and RR-TB cases increased 2.7 times (from 31 to 84). Meanwhile, the percentage of previously treated cases declined from 20.2 to 18.2% and the M.tb confirmed TB proportion increased from 34.7 to 49.7%.ConclusionThe elevated M.tb confirmed TB proportion and the declined percentage of previously treated cases indicated the improved TB diagnosis and treatment of AHZMU. However, the increasing number of total TB cases, new and RR-TB cases showed an upward trend and increased TB burden in a relatively underdeveloped area of China.
Prophylactic antibiotics may not be necessary for transoral endoscopic thyroidectomy
Authors: Lee Jun Sung , Kim Hee Jun , Lee Jin Seok , Yun Hyeok Jun , Lee Suji , Cheong Jae-Ho , Kim Soo Young , Kim Seok-Mo , Chang Hojin , Lee Yong Sang , Park Cheong Soo , Chang Hang-Seok 
Published: August 2022

BackgroundWith the recent advances in thyroid cancer surgery techniques and the increasing number of patients concerned about cosmetics, the use of transoral endoscopic thyroidectomy is increasing globally. The aim of this study was to determine whether transoral endoscopic thyroidectomy is truly a clean-contaminated surgery.MethodsFrom September 2016 to April 2018, 20 patients with thyroid cancer underwent transoral endoscopic thyroidectomy performed by a single surgeon at Gangnam Severance Hospital. Before and after surgery, the oral cavity was swabbed to obtain culture samples, and antibiotics were administered before and after surgery each once.ResultsOf the total 20 patients, no bacteria were identified before or after surgery in eight (40%) patients. Bacteria were identified both before and after surgery in seven patients (35%). In four patients (20%), bacteria were not identified before surgery, but bacteria were identified after surgery. Bacteria were identified before surgery but not after surgery in one patient (5%). No surgical site infection was observed. All the bacteria identified were normal flora of the oral cavity and skin.ConclusionsThere was no difference between the preoperative culture and postoperative culture of the oral cavity in patients undergoing TOET, and there were no postoperative surgical site infection with prophylactic pre &amp; post-operative antibiotics use. Considering the patient's position and surgical extent in TOET, it appears to be difficult for non-indigenous bacteria to invade the surgical site in oral cavity.
Case Report: Myomatous erythrocytosis syndrome presenting as rapid growth of an extra-uterine mass
Authors: Wang Shao-Jing , Chen Yun-An , Shih Yu-Hsiang , Chen Ming-Jer , Lu Chien-Hsing 
Published: August 2022

ObjectiveTo report a case of myomatous erythrocytosis syndrome (MES) with an extra-uterine manifestation.Case reportA 43-year-old woman presented with progressive abdominal distension and rapid enlargement of a pelvic mass. Upon survey, a high-level of hemoglobin (19.0 g/dl) was documented. The initial impression was an ovarian malignancy, but uterine sarcoma could not be ruled out because of its rapid growth. However, during exploratory laparotomy, the pelvic mass was found to be a 31 cm broad ligament leiomyoma; which is extremely rare for its size and location. The specimen was further studied immunohistochemically, which revealed excessive expressions of erythropoietin and erythropoietin receptors in addition to the diffusely matured blood vessels in the myoma tissue. The patient’s hemoglobin level resumed to normal three months post-surgery. The diagnosis of MES was confirmed both clinically and histologically.ConclusionA correct preoperative diagnosis is challenging when MES manifests as an extrauterine mass. The coexistence of MES should be considered in the management of all leiomyoma with polycythemia, regardless of locations.
Owner assessed outcomes following elbow arthroscopy with or without platelet rich plasma for fragmented medial coronoid process
Authors: Matos Cruz Alyssa M. , Mason David R. 
Published: August 2022

ObjectiveDocument the outcomes of bilateral arthroscopic subtotal coronoidectomy for the fragmented medial coronoid process, quantify persistent lameness that required additional treatment (PRP), and document the outcomes of dogs that followed up with PRP injections.Study designRetrospective study.Sample populationOverall, 115 dogs underwent arthroscopy alone and 31 received PRP at least 6 weeks after arthroscopy. The owner's response rate was ~50% (73 dogs).MethodsCollected data included signalment, unilateral or bilateral clinical signs, intra-articular chondroprotective injection during the procedure, if PRP intra-articular injection was received postoperatively, and if it was received, the time from the initial surgery to administration was recorded. Outcomes were assessed via standardized owner questionnaires using the Liverpool Osteoarthritis in Dogs (LOAD) score, the Canine Brief Pain Inventory (CBPI) score, and the overall quality of life (QOL) assessment.ResultsApproximately 20% of the patients received PRP post-operatively due to persistent lameness following surgery. Similar pain scores were found between the two groups with an average of 11–13 LOAD score, 13–15 CBPI score, and good quality of life. Older animals at the time of surgery and those that received pain-relieving medications after the procedure were more painful and affected their functional outcome. PRP as an adjunctive therapy achieved a perceived good to excellent quality of life in ~90% of pets in this population.ConclusionArthroscopy and subtotal coronoidectomy followed by PRP, if needed, seemed to decrease pain, and improve lameness in the long term.Clinical significancePRP should be considered as adjunctive therapy in dogs with the limited response to arthroscopy alone.
Analysis of Midrapidity pT Distributions of Identified Charged Particles in Pb + Pb Collisions at snn = 5.02 TeV Using Tsallis Distribution with Embedded Transverse Flow
Authors: Olimov Khusniddin K. , Liu Fu-Hu , Fedosimova Anastasiya I. , Lebedev Igor A. , Deppman Airton , Musaev Kobil A. , Shodmonov Maratbek Z. , Tukhtaev Boburbek J. 
Published: August 2022

The midrapidity transverse momentum distributions of the charged pions, kaons, protons, and antiprotons, measured by ALICE Collaboration at ten centrality classes of Pb + Pb collisions at snn = 5.02 TeV in the Large Hadron Collider (LHC, CERN, Switzerland), are successfully analyzed using combined minimum χ2 fits with a thermodynamically non-consistent, as well as thermodynamically consistent, Tsallis function with transverse flow. The extracted non-extensivity parameter q decreases systematically for all considered particle species with increasing Pb + Pb collision centrality, suggesting an increase in the degree of system thermalization with an increase in collision centrality. The results for q suggest quite a large degree of thermalization of quark–gluon plasma (QGP) created in central Pb + Pb collisions at snn = 5.02 TeV with the average number of participant nucleons ⟨Npart⟩ > 160. The obtained significantly different growth rates of transverse flow velocity, ⟨βT⟩, in regions ⟨Npart⟩ < 71 ± 7 and ⟨Npart⟩ > 71 ± 7 with the temperature parameter T0 remaining constant within uncertainties in region ⟨Npart⟩ > 71 ± 7 probably indicates that ⟨Npart⟩ ≈ 71 ± 7 (corresponding to ⟨dNch/dη⟩ ≈ 251 ± 20) is a threshold border value for a crossover transition from a dense hadronic state to the QGP phase (or mixed phase of QGP and hadrons) in Pb + Pb collisions at snn = 5.02 TeV. The threshold border value for transverse flow velocity ⟨βT⟩ ≈ 0.46 ± 0.03 (corresponding to ⟨Npart⟩ ≈ 71 ± 7), estimated by us in Pb + Pb collisions at snn = 5.02 TeV, agrees well with the corresponding border value ⟨βT⟩ ≈ 0.44 ± 0.02, recently obtained in Xe + Xe collisions at snn = 5.44 TeV, and with almost constant ⟨βT⟩ values extracted earlier in the Beam Energy Scan (BES) program of the Relativistic Heavy-Ion Collider (RHIC, Brookhaven, GA, USA) in central Au + Au collisions in the snn = 7.7 − 39 GeV energy range, where the threshold for QGP production is achieved. The correlations between extracted T0 and ⟨βT⟩ parameters are found to be greatly different in regions ⟨βT⟩ < 0.46 and ⟨βT⟩ > 0.46, which further supports our result obtained for the threshold border value in Pb + Pb collisions at snn = 5.02 TeV.
Safety and Efficacy of Patiromer in Hyperkalemic Patients with CKD: A Pooled Analysis of Three Randomized Trials
Authors: Haller Hermann , Bianchi Stefano , McCafferty Kieran , Arthur Susan , Quinn Carol Moreno , Budden Jeffery , Weir Matthew R. 
Published: August 2022

Key Points

Hyperkalemia is frequently observed in patients with CKD, and its frequency and severity increase as CKD progresses.Patiromer is an effective and well-tolerated treatment option for hyperkalemia in patients with advanced or mild/ moderate CKD on RAASi.

Background
Hyperkalemia is a common electrolyte abnormality in patients with CKD, which is associated with worse outcomes and limits use of renin–angiotensin–aldosterone system inhibitors (RAASi). This post hoc subgroup analysis of three clinical trials evaluated the efficacy and safety of the sodium-free, potassium-binding polymer, patiromer, for the treatment of hyperkalemia in adults with nondialysis CKD.

Methods
Data from the 4-week treatment periods of AMETHYST-DN, OPAL-HK, and TOURMALINE studies were combined. Patients had baseline diagnosis of CKD, hyperkalemia (serum potassium >5.0 mEq/L), and received patiromer 8.4–33.6 g/day. Patients were stratified by baseline eGFR into two subgroups: severe/end-stage CKD (stage 3b–5; eGFR <45 ml/min per 1.73 m2) and mild/moderate CKD (stage 1–3a; eGFR ≥45 ml/min per 1.73 m2). Efficacy was assessed by the change in serum potassium (mean±SE) from baseline to week 4. Safety assessments included incidence and severity of adverse events (AEs).

Results
Efficacy analyses (n=626; 62% male, mean age 66 years) included 417 (67%) patients with severe/end-stage CKD and 209 (33%) with mild/moderate CKD. Most patients were receiving RAASi therapy at baseline (severe/end-stage CKD 92%; mild/moderate CKD 98%). The mean±SE change in serum potassium (baseline to week 4) was −0.84±0.03 in the severe/end-stage CKD subgroup, and −0.60±0.04 mEq/L in the mild/moderate CKD subgroup. AEs were reported for 40% and 27% patients in the severe/end-stage and mild/moderate CKD subgroups, respectively, with 16% and 12% reporting AEs considered related to patiromer. The most frequent AEs were mild-to-moderate constipation (8% and 3%) and diarrhea (4% and 2%). AEs leading to patiromer discontinuation occurred in 6% and 2% of patients with severe/end-stage CKD, and mild/moderate CKD, respectively.

Conclusions
Patiromer was effective for treatment of hyperkalemia and well tolerated in patients across stages of CKD, most of whom were receiving guideline-recommended RAASi therapy.
PEDIATRICS IN THE REFLECTION OF FALERISTICS
Authors: Бугаевский К.А. , Бугаевская Н.А. 
Published: August 2022

В статье представлены результаты проведённого исследования, касающиеся представлению педиатрии в таких видах коллекционирования, как фалеристика. В работе представлены настольные и памятные медали, знаки участников конференций и съездов по педиатрии периода СССР и другой фалеристический материал, посвящённый различным разделам и направлениям современной педиатрии, и известным врачампедиатрам. Статья представляет интерес для широкого круга читателей.
The article presents the results of the research conducted on the presentation of pediatrics in such types of collectibles as faleristics. The work presents table and commemorative medals, signs of participants of conferences and congresses on pediatrics of the USSR period and other faleristic material devoted to various sections and directions of modern pediatrics and wellknown pediatricians.The article is of interest to a wide range of readers
Síndrome de Burnout y funcionamiento familiar
Authors: Delgado-Cevallos Daniela Vanessa , Cañizares-Medina Andrés Ernesto , Fernández-Aucapiña Nancy Yolanda 
Published: August 2022

El presente estudio se enfocó en determinar el Síndrome de Burnout y su incidencia en el funcionamiento familiar en docentes de la Unidad Académica de Ciencias Sociales de la UCACUE, Cuenca, Ecuador; el proceso metodológico es de tipo descriptivo con un enfoque cuantitativo. Las herramientas de recolección de información que se utilizaron fueron el cuestionario de Maslash Burnout Inventory (MBI). la funcionalidad familiar está comprendida por la interacción entre cada uno de los miembros de la familia, mediante el test FF-SIL que evalúa varias categorías que permiten determinar un diagnóstico de la funcionalidad familiar, mediante la evaluación del mismo se identifica que la funcionalidad familiar no está correlacionada con el síndrome de Burnout puesto que se identifica que el 84.38% y 12.5% de docentes tienen una familia funcional y moderadamente funcional y tan solo el 3,12% presenta a familia severamente disfuncional.
Measuring anxiety among young English language learners: Application of digital games for evaluation
Authors: Amoroso-Vivanco María Paulina , Vega-Auquilla Melita Vanessa 
Published: August 2022

The purpose of the following study was to evaluate how the impact of technology affects the anxiety of elementary school students in English classes in a private school in Cuenca, Ecuador. Through a mixed method approach using the Beck Anxiety Inventory (BAI). Results showed that students experienced a statistically significant decrease in anxiety after being assessed through Quizizz games compared to traditional pencil-and-paper assessments. It was also found that students' anxieties regarding assessments were primarily triggered by fear of consequences, failure, and not achieving perfect scores. Further research over longer periods is recommended.
Gestión ambiental del proceso minero metalúrgico. Caso: Región la Libertad, Perú
Authors: Morón-Paredes Gerardo 
Published: August 2022

La investigación tuvo como objetivo general determinar la manera en que influye la gestión ambiental en el proceso minero metalúrgico de Perú; La investigación fue de paradigma positivista de un enfoque cuantitativo, de diseño no experimental y nivel correlacional, en la cual se analizó a una muestra de 200 individuos: En cuanto a los resultados, los cuales fueron calculados de manera estadística a través de modelos descriptivos de frecuencias y de correlación, con un CH2, previo análisis de normalidad, lo cual permitió desarrollar el análisis correlativo de R de Pearson, entre ambas variables, alcanzando de esta manera un margen de significancia de 0.01 puntos, siendo esta significante, a su vez se encontró un nivel o índice de correlación del 0.965 puntos, lo cual determina la validez de la hipótesis general, que establece que la influencia de la gestión ambiental es positiva en el proceso minero metalúrgico de Perú.