bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Population-based Prospective Study on Obesity-related Non-communicable Diseases in Northern Iran
Authors: Motamed Nima , Zamani Farhad , Maadi Mansooreh , Ajdarkosh Hossein , Roozafzai Farzin , Keyvani Hossein , Poustchi Hossein , Shakeri Ramin , Ashrafi G. Hossein , Perumal Dhayaneethie , Rabiee Behnam , Moradi-Lakeh Maziar , Khoonsari Mahmoodreza , Ameli Mitra , Nikkhah Mehdi , Faraji Amir Hossein , Kheyri Zahedin , Sohrabi Masoud Reza , Amirkalali Bahare , Tameshkel Fahimeh Safarnezhad , Gholizadeh Esmaeel , Hosseini Seyed Hamzeh , Niya Mohammad Hadi Karbalaie 
Published: February 2022

Abstract
We conducted a population-based prospective study to assess prevalence and incidence rates of cardiovascular diseases (CVDs) and obesity-related metabolic disorders, and to evaluate predictive ability of various CVD risk assessment tools, in a population not represented in existing CVD cohorts. We enrolled 5,799 participants in Amol, a city in northern Iran, in 2009–2010, and carried out first repeated measurement (RM) after seven years (2016–2017). For all participants, demographic, anthropometric, laboratory, hepatobiliary imaging, and electrocardiography data have been collected in the enrollment and the first RM. At least two more RM phases, with 7-year intervals, are considered for a comprehensive evaluation of participants (commencing in 2023 and 2030). After enrollment, all participants have been and will be followed up annually for 20 years, both actively and passively. We adopted a multidisciplinary approach to overcome barriers to participation, and achieved a 7-year follow-up success rate of 93.0% with active follow-up of 5,394 participants aged 18–90 years. Of 160 deceased participants, 69 cases (43.1%) died due to CVDs during seven years. The study outcomes offer an evidence base for future researches, and inform policies regarding non-communicable diseases in Iran.
Effects of letrozole co-treatment on outcomes of gonadotropin releasing hormone antagonist cycles in POSEIDON group 3 and 4 expected poor responders
Authors: Kahraman Alper , Tulek Firat 
Published: February 2022

Abstract
Purpose: To evaluate the effects of adjuvant letrozole administration on outcomes of gonadotropin releasing hormone (GnRH) antagonist cycles with intracytoplasmic sperm injection in POSEIDON group 3 and 4 expected poor responder women. Methods: This study was conducted by retrospective analysis of patients with expected poor ovarian response (POSEIDON group 3 and 4) that underwent GnRH antagonist cycles with intra-cytoplasmic sperm injection between 2010 and 2020. A total of 488 patients with letrozole co-administration and 2564 patients without any adjuvant treatment that underwent GnRH antagonist cycles within the selected period of time were included in the study. Results: Implantation rates, clinical pregnancy rates and live birth delivery rates were significantly higher in letrozole administered patients in comparison to controls among POSEIDON group 3 women (0.39±0.46 vs 0.27±0.40, p=0.01; 46.1% vs 33%, p=0.014; 42.7% vs 31.5%, p=0.034, respectively). Mean total doses of gonadotropins required per cycle were significantly lower in letrozole administered patients among both POSEIDON group 3 and 4 women (2864.65±878.47 IU vs 3757.27±1088.89 IU, p<0.001; 3286.06±770.16 IU vs 3666.48±959.66 IU, p<0.001, respectively). Conclusion: Adjuvant letrozole co-administration in intracytoplasmic sperm injection cycles following GnRH antagonist protocol appears to improve implantation, clinical pregnancy and live birth delivery rates in women with POSEIDON group 3 expected poor ovarian response.
Mutated Processes Predict Immune Checkpoint Inhibitor Therapy Benefit in Metastatic Melanoma
Authors: Patterson Andrew , Auslander Noam 
Published: February 2022

Abstract
Immune Checkpoint Inhibitor (ICI) therapy has revolutionized treatment for advanced melanoma; however, only a subset of patients benefit from this treatment. Despite considerable efforts, the Tumor Mutation Burden (TMB) is the only U.S. Food and Drug Administration (FDA) approved biomarker for ICI treatment in melanoma. However, the mechanisms underlying TMB association with prolonged ICI survival are not entirely understood and may depend on numerous confounding factors. To identify more interpretable ICI response biomarkers based on tumor mutations, we trained classifiers using mutations within distinct biological processes. We evaluated a variety of feature selection and classification methods, and identified key mutated biological processes that provide improved predictive capability compared to the TMB. The top mutated processes identified are leukocyte and T-cell proliferation regulation; importantly, these processes demonstrate stable predictive performance across different data cohorts of melanoma patients treated with ICI. This study provides new methodology to construct biologically interpretable genomic predictors for ICI response with substantially improved predictive performance over the TMB.
Gravitational Perturbations Correlated With The Asteroid Kinetic Impact Deflection Technique
Authors: Chagas B.S , Prado A. F. B. A. , Winter O. C. 
Published: February 2022

Abstract
We will present the use of the kinetic impact technique as a way to deflect asteroids that may present some risk of collision with Earth at any given time. Within the work to be developed here, we intend to evaluate in more detail the possibility to deflect the orbit of the asteroid 101955 Bennu, applying variations in its velocity (∆v) at different positions within its orbital period and measuring close encounters with planet Earth. We will see that, in a relatively long period of time, the asteroid has several close encounters with the planet, thus suffering a natural gravitational perturbation. With the application of the impulses, the relative distances change, causing variations in the energy of the asteroid and a large variation in the relative distance between the asteroid and Earth over a long period after the impulse. We present results in relation to the intensity of the applied impulse, which is important due to the size of the impactor to be considered and, for that, we mapped the positions of the impulses along a period of the orbit of the asteroid (M.I.O.A.). We finish by explaining what happens to the orbit of the asteroid during the periods of gravitational perturbation, since it undergoes to several “Swing Bys’ that intensify the variations of the relative distances between the bodies after the impulses.
Workstation Ergonomic Risk Factors and its associations with Common Musculoskeletal Complaints among Academic Staff of a Ghanaian Higher Institution: A survey
Authors: Bello Ajediran , Ahike Elaine , Ndaa Peter , Iyor Fidelis 
Published: February 2022

Abstract
Background: Despite the exposure of academic staff to the ergonomic risk factors associated with workstation seat, the prevalence of musculoskeletal complaints (MSCs) is under-reported in higher institutions of learning in Ghana. We therefore evaluated the workstation seat in relation to the academics’ body dimensions and the associations of the outcome with MSCs. Materials and Methods: Participants in this cross-sectional study were academic staff of a foremost health training institution in Ghana. They were enrolled into the study using convenience sampling method. We evaluated the body-chair dimension of the participants individually at each workstation using non-elastic 3-meter long tape measure. Nordic Musculoskeletal Questionnaire and ergonomics assessment checklist were used to determine the prevalence and ergonomic risk factors of MSC. Data analysis involved mean, frequency and standard deviation. We analyzed the association between body-chair dimensions and self-reported MSCs with Chi square test, at P < 0.05 level of significance. Results: Eighty-two (82) academic staff comprising 54, (65.9%) males and (28, 34.1) females participated fully in the study, of which 69 (84.2%) were Senior Lecturers. Thirty-four (41.5%) of the lecturers had worked between 5 and 10 years. The period and point prevalence of MSCs were 64.6% and 59.6% respectively. The body-chair mismatch and workstation ergonomic risk factors were significant associated with (P <0.001) MSCs.Conclusion: Our findings indicate moderate prevalence of MSCs among the participants with low back pain being the most reported complaint, which seemed to have a link with body-chair dimension mismatch. These findings are implicated for procurement policy, regarding workstation seat in higher institutions.
Do Not Resuscitate Orders and Outcomes for Patients with Pancreatic Cancer
Authors: Hao Qiang , Segel Joel E. , Gusani Niraj J. , Hollenbeak Christopher S. 
Published: February 2022

Abstract
Background: The impact of do-not-resuscitate (DNR) order on patients with pancreatic cancer remains uncertain. In this study, we evaluated whether DNR status was associated with in-hospital mortality and costs for the inpatient stay among patients hospitalized with pancreatic cancer.Methods: Data were from the National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), and included 40,246 pancreatic cancer admissions between 2011 and 2016. Mortality was modeled using a logistic regression model; costs for the inpatient stay were modeled using a multivariable generalized linear regression model.Results: The sample included 6,041 (15%) patients with a documented DNR. After controlling for covariates, patients with a DNR order had approximately 6 times greater odds of mortality compared to patients without a DNR order (OR 5.90, p<0.0001). Compared to patients without a DNR order who survived during the hospital stay, patients with a DNR order who died during the hospital stay had significantly lower costs (-US$983; p=0.0270), and patients without a DNR order who died during the hospital stay had significantly higher costs (US$5,638; p<0.0001). Patients with a DNR order who survived had costs that were not significantly different from patients without a DNR order who survived.Conclusions: The presence of a DNR order among patients with pancreatic cancer was significantly associated with higher mortality risk, as well as lower costs for the patients who died during the hospital stay. However, DNR status was not significantly associated with costs for patients with pancreatic cancer who were discharged alive.
Factors Associated With Non-Participation In Cervical Cancer Screening In Yaoundé: A Mixed Quantitative And Qualitative Study
Authors: Ngassam Anny , Kemfang Jean Dupont , Wafeu Sadeu Guy , Meka Esther Ngo Um , Tsuala Jovany Fouogue , Kasia Jean Marie 
Published: February 2022

Abstract
Background: The weak participation of women to cervical cancer screening is a major obstacle to the fight against that disease. This work had as objective to determine associated factors to the lack of cervical cancer screening in women in Cameroon, a middle-income country of Central Africa.Methods: We conducted a cross-sectional analytic study both quantitative and qualitative on 1000 sexually active women aged 25 years old and above coming to the gynecology department of the Centre hospitalier de recherche et d’application en chirurgie endoscopique et reproduction humaine from March to December 2017. Results: The mean age of the studied women was 37.1 ±10.1 years old, among them 733 (73.3%) had never been screened. Associated factors to the absence of previous screening were : age lower than 35 years old (OR=5.0 ; 95% CI : 3.6 – 6.9), Islam (OR=3.3 ; 95% CI :1.6 – 6.7), unemployment (OR=2 ; 95% CI : 1.5-2.7) and bachelorhood (OR=1.5 ; 95% CI: 1.1 – 2.1). The main evoked barriers to screening were: fear of cancer, inadequate sensitization, the lack of screening prescription by the medical staff and ignorance about the usefulness of screening. Conclusion: It is important to diversify the means of communication on cervical cancer while focusing specifically on groups associated with the greatest lack of screening participation. Increased screening prescriptions by healthcare workers could also increase screening participation of women.
The return of RET GateKeeper mutations? An In-silico exploratory analysis of potential resistance mechanisms to novel RET macrocyclic inhibitor TPX-0046
Authors: Repetto Matteo , Crimini Edoardo , Ascione Liliana , Bielo Luca Boscolo , Belli Carmen , Curigliano Giuseppe 
Published: February 2022

Abstract
Purpose: TPX-0046 is designed to overcome resistance to FDA approved RET inhibitors Selpercatinib and Pralsetinib. Early prediction of resistance mechanisms to investigational drugs may facilitate subsequent drug and trial designs. This study aims to predict potential mutations inducing resistance to TPX-0046.Materials and methods: We conducted an in-silico analysis of TPX-0046 macrocyclic structure and predicted the binding mode on RET. We used as reference literary examples of resistance mechanisms to other macrocyclic inhibitors (Lorlatinib on ALK/ROS1) to construct RET secondary resistance mutations. We conducted docking simulations to evaluate impact of mutations on TPX-0046 binding.Results: TPX-0046 binding mode on RET appears to not be influenced by Solventfront G810X mutation presence. Bulky Gatekeeper V804X mutations affect predicted TPX-0046 binding mode. Mutations in Beta 7 strand region L881F and xDFG S891L impair TPX-0046 docking.Conclusions: Our findings suggest that development of second generation RET inhibitors focused mainly on Solventfront G810X mutations granting resistance to selective RET inhibitors Selpercatinib and Pralsetinib. If these findings are confirmed by identification of Gatekeeper V804X mutations in patients progressing to TPX-0046, explanation of acquired resistance and loss of benefit will be easier These findings might accelerate development of third generation RET inhibitors, as well as clinical trial design in precision oncology settings.
Triiodothyronine Treatment Reverses Depression-Like Behavior in a Triple-Transgenic Animal Model of Alzheimer’s Disease.
Authors: Maglione Andrea , Nascimento Bruna , Ribeiro Miriam , Souza Talytha , Silva Renata , Sato Monica , Penatti Carlos , Britto Luiz , Souza Janaina , Maciel Rui , Conceição Rodrigo Rodrigues da , Melo Roberto Laureano - , Giannocco Gisele 
Published: February 2022

Abstract
Introduction: Alzheimer disease’s (AD) is a neurodegenerative disorder and it is known that the central nervous system (CNS) is an important target of thyroid hormones (TH). Moreover, an inverse association between serum triiodothyronine (T3) levels and the risk of AD was reported. Aim: To evaluate the effects of T3 treatment on the depression-like behavior observed in male transgenic 3xTg-AD mice. Main methods: Animals were divided into 2 groups, one group received daily intraperitoneal injections of L-T3 (T3 group), and the other received an equivalent volume of 0.9% saline (Control group). The experimental protocol lasted 21 days, and behavioral tests were conducted on days 15-19. At the conclusion of the experiment, the TH profile and hippocampal gene expression were evaluated. Key findings: It was observed that the T3-treated group presented significantly increased serum T3 and decreased thyroxine (T4) levels. When compared to control hippocampal samples, the T3 group exhibited attenuated glycogen synthase kinase-3 (GSK3), metalloproteinase 10 (ADAM10), amyloid-beta precursor-protein (APP), serotonin transporter (SERT), 5HT1a receptor, monocarboxylate transporter 8 (MCT8) and bone morphogenetic protein 7 (BMP-7) gene expression levels and augmented superoxide dismutase 2 (SOD2) and Hairless gene expression levels. Additionally, T3-treated animals displayed reduced immobility time in both the tail suspension and forced swim tests, and in the latter presented a higher latency time when compared to the control group. Significance: Taken together, our results demonstrate that in an AD mouse model, T3 supplementation promotes improvements in depression-like behavior, likely through the modulation of the serotonergic pathway, and also attenuated disease progression.
Direct identification of interfacial degradation in blue phosphorescent OLEDs using nanoscale chemical depth profiling
Authors: Sul Soohwan , Trindade Gustavo , Kim Joonghyuk , Havelund Rasmus , Park Sungjun , Shin Youngsik , Bae Hyejin , Sung Young Mo , Matjacic Lidija , Jung Yongsik , Won Jung Yeon , Jeon Woo Sung , Choi Hyeonho , Lee Hyo Sug , Lee Jae-Cheol , Kim Jung-Hwa , Gilmore Ian 
Published: February 2022

Abstract
Understanding the degradation mechanism of organic light-emitting diodes (OLED) is essential to improve device performance and stability. OLED failure, if not process-related, arises mostly from chemical instability. However, the challenges of sampling from nanoscale organic layers and interfaces with enough analytical information has hampered identification of degradation products and mechanisms. Here, we present a high-resolution diagnostic method of OLED degradation using an Orbitrap mass spectrometer equipped with a gas cluster ion beam to gently desorb nanometre levels of materials, providing unambiguous molecular information with 7-nm depth resolution. We measured blue phosphorescent OLED devices and showed that dominant chemical degradation occurred at the interface between electron transport and emission layers (EML/ETL) where exciton distribution was maximised. We also show an approximately two orders of magnitude increase in lifetime of a device with slightly modified host material, which presented negligible EML/ETL interfacial degradation. Our results provide insight for material and device architecture development.
Autophagy Inhibits Renal Tubule Inflammation in Diabetic Kidney Disease Mice Via Inhibition of NLRP3 Inflammasome
Authors: Xinxin Pang , Zhang Ya-ge , Zhang Li-jie , Zhu Qing , Shang Hai-tao , Wang Zhen-tao 
Published: February 2022

Abstract
Background

Diabetic kidney disease (DKD) has become the leading cause of chronic kidney disease and numerous reports have validated that renal tubule inflammation participate in DKD progression. However, the molecular mechanism underlying renal tubular inflammatory damage in DKD remains to be completely elucidated. The aim of this study is to investigate the effect of rapamycin-induced autophagy on Nod-like receptor family protein 3 (NLRP3) inflammasome and inflammation of renal tubular epithelial cells in DKD.
Methods

We collected kidney tissue specimens from patients with DKD and transplanted kidney donors for histopathological examination and performed urine and blood samples. The STZ-induced DKD mice model was established for in vivo study. The mice were divided into three groups: Ctrl, DKD, DKD+Rapa. Collected the serum for 24 h protein quantification, blood glucose, C-peptide and insulin level investigations. PAS staining and electron microscopy were used to visualize the pathological changes in the kidney and the expressions of Beclin1, P62, NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) protein, interleukin (IL)-1β, IL-18, β2-microglobulin (β2-MG); 24 urine protein, and creatinine in the kidney tissue were detected. Moreover, human renal proximal tubule cells (HK-2) were cultured in vitro, and high glucose was used to induce the model, followed by rapamycin treatment. The protein expression of Beclin1, P62, ASC protein, IL-1β, IL-18, 24 urine protein, and creatinine were analyzed.
Results

Compared with the model group mice, after rapamycin treatment, urinary protein decreased quantitatively, blood glucose decreased, C-peptide and insulin levels increased (P<0.01), glomerular basement membrane did not thicken obviously, and the expressions of P62, NLRP3, ASC protein, IL-1β and IL-18 protein in renal tissue decreased, while Beclin-1 level increased (P<0.05). After high glucose intervention in vitro, the expression of NLRP3, ASC protein, IL-1β and IL-18 protein in HK-2 cells increased, while the level of Beclin-1 decreased. The expression of NLRP3, ASC, IL-1β and IL-18 decreased and Beclin-1 level increased after rapamycin intervention (P<0.05).
Conclusion

The findings of the present study indicated that the NLRP3 inflammasomemediated inflammatory response was activated in DKD. Rapamycin can inhibit the activation of NLRP3 inflammasome in DKD by enhancing autophagy.
An Intrinsically Glassy Metallic Coordination Polymer Showing Thermally and Aerobically Robust Conductivity
Authors: Anderson John , Xie Jiaze , Ewing Simon , Boyn Jan-Niklas , Cheng Baorui , Filatov Alexander , Ma Tengzhou , Zhao Norman , Itani Ram , Sun Xiaotong , Cho Himchan , Patel Shrayesh , Talapin Dmitri , Park Jiwoong , Mazziotti David 
Published: February 2022

Abstract
Conducting organic materials, such as doped organic polymers, (1) molecular conductors, (2,3) and emerging coordination polymers, (4) underpin technologies ranging from displays to flexible electronics. (5) Realizing high electrical conductivity in traditionally insulating organic materials necessitates tuning their electronic structure through chemical doping. (6) Furthermore, even materials that are intrinsically conductive, such as single-component molecular conductors, (7,8) require crystallinity for metallic behavior. However, commercial conducting polymers are often purposefully amorphous to aid in durability and processability. (9,10) Using molecular design to engender high conductivity in undoped amorphous materials would enable tunable and robust conductivity in many applications, but there are no intrinsically conducting organic materials which maintain high conductivity when disordered. Here we show that the completely amorphous coordination polymer Ni tetrathiafulvalene tetrathiolate (NiTTFtt) displays intrinsic metallic conductivity. Despite its disordered structure, NiTTFtt exhibits remarkably high electronic conductivity (1280 S/cm) and intrinsically glassy metallic behavior. Analysis with advanced theory shows that these properties are enabled by strong molecular overlap and correlation that are robust to structural perturbations. This unusual set of structural and electronic features results in remarkably stable organic conductivity which is maintained in air for weeks and at temperatures up to 140 °C. Our results demonstrate that molecular design can enable metallic conductivity even in heavily disordered materials. This both raises fundamental questions about how band-like transport can exist in the absence of periodic structure as well as suggests exciting new applications for these materials.