bluuebunny/crossref_metadata_2025_split huggingface dataset:
Suplementação de prebióticos e probióticos em crianças autistas: revisão integrativa
Authors: Brandão Thaynara Lays Sales , Silva Júlia Carolina Lopes , Campos Sarah Évelin Dias , Francelino Jakeline Olindina 
Published: January 2022

Objetivo: Avaliar o uso da suplementação de probióticos e prebióticos em crianças autistas. Metodologia: Foram identificados artigos nas bases de dados PubMed e SciELO. Para a localização dos estudos foram utilizados descritores em inglês cadastrados no Descritores em Ciências da Saúde (DeCS): Prebiotics. Probiotics. Autism Spectrum Disorder. Gut microbiota. Bifidobacterium. A busca limitou-se a artigos em inglês e compreendeu os anos de publicação entre 2015-2021. Resultados: Um total de 6 ensaios clínicos realizados em crianças com autismo foram revisados sistematicamente. Com relação aos tipos de suplementações utilizadas foram 3 estudos que utilizaram probióticos, 2 que utilizaram prebióticos e probióticos e 1 que fez apenas o uso de prebióticos. Apesar da quantidade escassa de estudos, os mesmos tiveram resultados notáveis com relação à suplementação de probióticos e prebióticos em crianças com Transtorno do Espectro Autista. Em alguns estudos foi possível observar a melhora na gravidade do autismo e melhorias com relação ao comportamento antissocial, já em outros houve o aumento de bactérias benéficas e diminuição das patogênicas no trato gastrintestinal levando a melhora de sintomas gastrointestinais recorrentes. Conclusão: O uso de prebióticos e probióticos apresentam resultados significativos em crianças com TEA, sendo uma terapia alternativa, promissora e complementar. Ainda assim, há a necessidade que mais ensaios clínicos sejam realizados acerca do assunto, pois são escassos e com amostras pequenas.
A importância da conciliação medicamentosa em hospitais brasileiros
Authors: Silva Weilla Patrícia Cordeiro , Ribeiro Aline Farias , Arruda José Eduardo Gomes 
Published: January 2022

A conciliação de medicamentos relaciona-se diretamente com a segurança das pessoas nos diferentes níveis de assistência à saúde em que os medicamentos são utilizados como principais tecnologias para a cura, diagnóstico e o controle de doenças. Foi realizada uma revisão integrativa da literatura com o objetivo de conhecer acerca da importância da conciliação medicamentosa para garantir a segurança do paciente hospitalizado. O levantamento bibliográfico abrangeu estudos somente em português, publicados entre 2016 a 2021, em periódicos científicos e que estivessem adequados ao tema proposto para o trabalho, a pesquisa foi realizada no mês de novembro de 2021 nas bases de dados PubMed, SCIELO, portal CAPES, LILACS, Google acadêmico e BVS, utilizando os seguintes descritores: “conciliação medicamentosa”, “hospital”, “Brasil” e “segurança do paciente”. Sendo identificados, após análise, 13 artigos que compuseram a amostra do estudo. Os resultados apontam que na maior parte dos artigos analisados, a conciliação medicamentosa em pacientes hospitalizados, apresenta-se como fundamental para a segurança do mesmo. Em todos conseguimos perceber a importância de se monitorar as prescrições e trabalhar em conjunto com a equipe multiprofissional. Portanto, foi de extrema relevância a realização desta revisão integrativa para a comprovação que o cuidado farmacêutico é uma ferramenta positiva para a saúde da população. Contudo, observou-se carência em estudos sobre a conciliação medicamentosa em hospitais brasileiros.
A reestruturação de um projeto odontológico para pessoas com TEA em tempos de Covid-19
Authors: Ferreira Fabiana Vargas , Ferreira Fernanda Vargas , Moura Rosa Núbia Vieira de , Carrer Juliana de Miranda , Andrade Júlia Rodrigues , Gaudêncio Laura Gismonti de Araújo , Silva Danielle Cristine Gonçalves da , Santos Dyorjenes Henrique Andrade , Souza Laura Beatriz de Jesus , Castilho Lia Silva de 
Published: January 2022

Objetivo: este estudo descreve as estratégias adotadas por um Projeto de Extensão Odontológico para pessoas com Transtorno do Espectro Autista na Universidade Federal de Minas Gerais, abordando a introdução de mídias sociais e as tecnologias assistivas empregadas durante a pandemia do COVID 19 na interlocução com estes pacientes. Método: foi analisado o registro no SIEX deste projeto (403506) em relação aos resultados atingidos e aos produtos efetivamente entregues ao público alvo e à comunidade científica. Resultados: Foram encontrados vídeos institucionais e oficinas participativas demonstrando como elaborar materiais motivacionais para higiene bucal, alimentação e postagens em Instagram para a comunidade em geral e comunidade acadêmica, participações em eventos científicos, elaboração de cartilhas, redação de artigos científicos e dissertação de mestrado. Conclusão: A relação dialógica com a sociedade e o impacto e transformação social só poderão ser mensurados com o retorno presencial às clínicas. O emprego da comunicação remota pode ter prejudicado a interação entre a equipe multidisciplinar e está população tão singular em termos de interação social. O projeto de extensão “Atendimento odontológico à pessoa com TEA” se esforçou em manter estes canais de relacionamento abertos com esta população e espera que este esforço possa mitigar os efeitos do isolamento social na promoção de saúde bucal da pessoa com TEA.
PENGEMBANGAN KAWASAN EKOWISATA DALAM ROADMAP SISTEM INOVASI DAERAH (SIDA) KABUPATEN LABUHANBATU MELALUI PARIWISATA BERBASIS MASYARAKAT
Authors: Doni Sefri , Prasetyo Andjar 
Published: January 2022

Penelitian ini dilatarbelakangi oleh upaya Pemerintah kabupaten Labuhanbatu meningkatakan daya saing daerah melalui ekowisata. Tujuan penelitian ini adalah memetakan potensi lokus kajian dalam pengembangan ekowisata, menganalisis kesiapan ekowisata melalui pariwisata berbasis masyarakat, mengevaluasi potensi pengembangan ekowisata dalam Roadmap SIDa Kabupaten Labuhanbatu tahun 2021-2026. Penelitian ini menjadi sangat penting mengingat adanya objek wisata berbasais alam yang potensial untuk dikembangkan. Metode deskriptif digunakan untuk menarasikan penelitian secara kualitatif. Lokus kajian terdiri dari delapan desa/kelurahan yaitu Sei Berombang, Sei Lumut, Sei Sakat, Sei Penggantungan, Sei Tawar, Sirondorung, Kampung Dalam dan Lobusona di Kabupaten Labuhan Batu Provinsi Sumatera Utara dengan waktu penelitian bulan Januari sampai Mei 2021. Sumber utama data sekunder berasal dari Naskah Akademik Rencana Induk Pembangunan Pariwisata Kabupaten Labuhanbatu tahun 2019-2025 dan Badan Pusat Statistik Kabupaten Labuhanbatu berupa kuantitas data berkaitan dengan lokus penelitian, sedangkan data primer berasal dari hasil wawancara dan kuisioner terhadap responden di lokus kajian. Analisis menggunakan tahapan pariwisata berbasis masyarakat dengan implementasi pada Roadmap SIDa. Hasil penelitian menunjukan bahwa lokus kajian memiliki potensi pengembangan ekowisata berdasarkan pemetaan, tahapan dalam pariwisata berbasis masyarakat masih membutuhkan berbagai pendukung baik dari sisi kelembagaan, SDM, maupun proses ekowisata. Kebutuhan dalam pengembangan ekowisata ini dapat diintervensi melalui Roadmap SIDa Kabupaten Labuhanbatu tahun 2021-2026. Di samping itu terdapat potensi partisipasi masyarakat secara berkelanjutan dan menimbulkan peningkatan daya saing daerah.
Kata Kunci: Ekowisata, Roadmap Sistem Inovasi Daerah, Pemberdayaan Masyarakat, Pariwisata Berbasis Masyarakat
FACTORS THAT INFLUENCE THE DECISION TO ELECT YOUNG VOTERS IN THE 2020 ELECTIONS
Authors: Citrayanti Sherly Alifah , Yuhertiana Indrawati 
Published: January 2022

The Covid-19 pandemic has made the government work harder to adapt to conditions that are still critical. All areas of life have undergone very significant changes so that the government pays special attention to immediately make new policies by innovating so that everything returns to normal. In times like today, the government needs an update that brings changes for the better. Brilliant thoughts and ideas are needed to be able to lift Indonesia to adapt to the situation. One of them can start by improving human resources in the government sector with the implementation of the simultaneous Regional Head Elections in 2020 later, the elected people will become the channel for public aspirations to work together in synergy to overcome the current pandemic situation. Public participation is needed to choose which candidates are ready to devote their bodies and mind to Indonesia. Therefore, it is important to know the track record of regional head candidates because it will impact their performance in the next leadership period. In addition, social political culture can shape the personality and thoughts of a group. The purpose of this study is to find out and empirically test the influence of the track record of regional head candidates, government financial information, and political culture on the decision to choose young voters in the 2020 Pilkada. The method used in this research is quantitative with a questionnaire technique and analyzed by Smart PLS. The population used active students class 2017 at UPN "Veteran" East Java. The results show that work experience, education level, socio-economic background of regional head candidates, government financial information, and political culture positively and significantly impact the decision to choose young voters in the 2020 simultaneous elections.
Keywords: Track Record, Financial Information, Political Culture, Regional Head Election 2020, Luder Contingency Model
REBRANDING BADAN KEPENDUDUKAN DAN KELUARGA BERENCANA NASIONAL DALAM MENYASAR GENERASI MILLENIAL DAN ZILLENIAL
Authors: Fauzia Rizky 
Published: January 2022

Penelitian ini bertujuan untuk mendeskripsikan proses rebranding Badan Kependudukan dan Keluarga Berencana Nasional (BKKBN) dengan menggunakan metode penelitian deskriptif kualitatif. Teknik pengumpukan data dilakukan dengan cara studi dokumen dan observasi dengan terjun langsung di lapangan. Hasil penelitian menunjukkan bahwa rebranding BKKBN sudah dimulai pada tahun 2009 pascareformasi atau setelah diterapkannya Otonomi Daerah di Indonesia. Namun pada tahun 2019 BKKBN menginisiasikan formalitas rebranding dalam peraturan lembaga. Penelitian ini menjelaskan secara detail pelaksanaan rebranding BKKBN dengan melakukan empat elemen rebranding yaitu repositioning, renaming, redesign, dan relaunch. Hasil penelitian menunjukkan bahwa repositioning BKKBN dilakukan dengan menentukan target segmentasi audiens BKKBN yang berfokus pada generasi millenial dan zillenial serta mengubah posisi BKKBN dari isu fertilitas menjadi “Sahabat Keluarga”. Pada proses renaming BKKBN tidak mengubah namanya karena UU No. 52 Tahun 2009 masih relevan sehingga yang diganti hanyalah visi dan misi BKKBN agar lebih relatable dengan kondisi saat ini. Pada tahap redesign BKKBN melibatkan publik dengan mengadakan lomba logo, tagline, dan jingle, expert meeting serta pre-testing hasil lomba. Logo baru BKKBN berbentuk hati, kupu-kupu dan berwarna biru, tagline BKKBN adalah “Berencana itu Keren”. Proses relaunch menemui banyak hambatan dari pengunduran karena pematangan konsep logo, tagline, dan theme song serta pandemi Covid-19. Soft launching pemenang jingle lomba dan aransemen ulang Mars KB diadakan pada 19 Desember 2019. Peluncuran logo baru BKKBN dilakukan di internal BKKBN, seluruh media sosial @BKKBNOfficial dan penyebarluasan siaran pers. Terakhir Grand launching rebranding diadakan berbarengan dengan Hari Keluarga Nasional ke-XXVI pada 29 Juni 2020.
Kata kunci: rebranding, komunikasi, BKKBN, brand image
Single-Atom Fe-Anchored Nano-Diamond With Enhanced Dual-Enzyme Mimicking Performance for H2O2 and Glutathione Detection
Authors: Liu Ying , Yan Jianghong , Huang Yu , Sun Zhiheng , Zhang Huijing , Fu Lihaoyuan , Li Xuwen , Jin Yongri 
Published: January 2022

Glutathione (GSH) is an important antioxidant and free radical scavenger that converts harmful toxins into harmless substances and excretes them out of the body. In the present study, we successfully prepared single-atom iron oxide-nanoparticle (Fe-NP)-modified nanodiamonds (NDs) named Fe-NDs via a one-pot in situ reduction method. This nanozyme functionally mimics two major enzymes, namely, peroxidase and oxidase. Accordingly, a colorimetric sensing platform was designed to detect hydrogen peroxide (H2O2) and GSH. Owing to their peroxidase-like activity, Fe-NDs can oxidize colorless 3,3′,5,5′-tetramethylbenzidine (TMB) into blue with sufficient linearity at H2O2 concentrations of 1–60 μM and with a detection limit of 0.3 μM. Furthermore, using different concentrations of GSH, oxidized TMB can be reduced to TMB, and the color change from blue to nearly colorless can be observed by the naked eye (linear range, 1–25 μM; detection limit, 0.072 μM). The established colorimetric method based on oxidase-like activity can be successfully used to detect reduced GSH in tablets and injections with good selectivity and high sensitivity. The results of this study exhibited reliable consistency with the detection results obtained using high-performance liquid chromatography (HPLC). Therefore, the Fe-NDs colorimetric sensor designed in this study offers adequate accuracy and sensitivity.
Evaluation of Analytical Performances of Magnetic Force-Assisted Electrochemical Sandwich Immunoassay for the Quantification of Carcinoembryonic Antigen
Authors: Hwang Boo Young , Kim Eunsoo , Kim Seung-ha , Hwang Hyundoo 
Published: January 2022

Carcinoembryonic antigen (CEA) is a biomarker indicated in different cancers, targeted for quantitative analysis via immunoassay. Here we introduce a new technique called magnetic force-assisted electrochemical sandwich immunoassay (MESIA) for determination of CEA level in a drop of human serum using a fully automated point-of-care testing (POCT) device. The analytical performances of the assay are assessed based on precision, accuracy, limit of blank (LoB), limit of detection (LoD) and limit of quantitation (LoQ), linearity, Hook effect, interference, cross-reactivity, and method comparison following the guidelines of the Clinical Laboratory Standards Institute (CLSI). The LoD is 0.50 ng/ml. A linear relationship is shown in the range of 0.5–200 ng/ml. A high dose effect is not seen up to approximately 500,000 ng/ml. The recovery range is from 94.7 to 108.9%. The %CV of run-to-run and within-lab variations are less than 2.04 and 4.41% across the CEA concentrations, respectively, whereas reproducibility is 4.45–6.24%. Method comparison shows that the assay correlates well with the reference device (R2 = 0.9884). The assay demonstrates acceptable precision, accuracy, LoB, LoD and LoQ, hook effect, linearity, interference, cross-reactivity, and high correlation with its reference device. Thus, the system is suitable for the quantification of CEA in clinical practices with a POCT manner.
The Clock Takes Shape—24 h Dynamics in Genome Topology
Authors: Tartour Kévin , Padmanabhan Kiran 
Published: January 2022

Circadian rhythms orchestrate organismal physiology and behavior in order to anticipate daily changes in the environment. Virtually all cells have an internal rhythm that is synchronized every day by Zeitgebers (environmental cues). The synchrony between clocks within the animal enables the fitness and the health of organisms. Conversely, disruption of rhythms is linked to a variety of disorders: aging, cancer, metabolic diseases, and psychological disorders among others. At the cellular level, mammalian circadian rhythms are built on several layers of complexity. The transcriptional-translational feedback loop (TTFL) was the first to be described in the 90s. Thereafter oscillations in epigenetic marks highlighted the role of chromatin state in organizing the TTFL. More recently, studies on the 3D organization of the genome suggest that genome topology could be yet another layer of control on cellular circadian rhythms. The dynamic nature of genome topology over a solar day implies that the 3D mammalian genome has to be considered in the fourth dimension-in time. Whether oscillations in genome topology are a consequence of 24 h gene-expression or a driver of transcriptional cycles remains an open question. All said and done, circadian clock-gated phenomena such as gene expression, DNA damage response, cell metabolism and animal behavior—go hand in hand with 24 h rhythms in genome topology.
Alterations of Gut Microbiome and Serum Metabolome in Coronary Artery Disease Patients Complicated With Non-alcoholic Fatty Liver Disease Are Associated With Adverse Cardiovascular Outcomes
Authors: Hu Xiaomin , Zhou Ruilin , Li Hanyu , Zhao Xinyue , Sun Yueshen , Fan Yue , Zhang Shuyang 
Published: January 2022

Rationale: Patients suffering from coronary artery disease (CAD) complicated with nonalcoholic fatty liver disease (NAFLD) present worse cardiovascular outcomes than CAD patients without NAFLD. The progression of CAD is recently reported to be associated with gut microbiota and microbe-derived metabolites. However, it remains unclear how the complication of NAFLD will affect gut microbiota and microbe-derived metabolites in CAD patients, and whether or not this interplay is related to the worse cardiovascular outcomes in CAD-NAFLD patients.Methods: We performed 16S rRNA sequencing and serum metabolomic analysis in 27 CAD patients with NAFLD, 81 CAD patients without NAFLD, and 24 matched healthy volunteers. Predicted functional profiling was achieved using PICRUSt2. The occurrence of cardiovascular events was assessed by a follow-up study. The association of alterations in the gut microbiome and metabolome with adverse cardiovascular events and clinical indicators was revealed by Spearman correlation analysis.Results: We discovered that the complication of NAFLD was associated with worse clinical outcomes in CAD patients and critical serum metabolome shifts. We identified 25 metabolite modules that were correlated with poor clinical outcome in CAD-NAFLD patients compared with non-NAFLD patients, represented by increased cardiac-toxic metabolites including prochloraz, brofaromine, aristolochic acid, triethanolamine, and reduced potentially beneficial metabolites including estradiol, chitotriose, palmitelaidic acid, and moxisylyte. In addition, the gut microbiome of individuals with CAD-NAFLD was changed and characterized by increased abundances of Oscillibacter ruminantium and Dialister invisus, and decreased abundances of Fusicatenibacter saccharivorans, Bacteroides ovatus and Prevotella copri. PICRUSt2 further confirmed an increase of potential pathogenic bacteria in CAD-NAFLD. Moreover, we found that variations of gut microbiota were critically correlated with changed circulating metabolites and clinical outcomes, which revealed that aberrant gut microbiota in CAD-NAFLD patients may sculpt a detrimental metabolome which results in adverse cardiovascular outcomes.Conclusions: Our findings suggest that CAD patients complicated with NAFLD result in worse clinical outcomes possibly by modulating the features of the gut microbiota and circulating metabolites. We introduce “liver-gut microbiota-heart axis” as a possible mechanism underlying this interrelationship. Our study provides new insights on the contribution of gut microbiota heterogeneity to CAD-NAFLD progression and suggests novel strategies for disease therapy.
Assessing the Geothermal Resource Potential of an Active Oil Field by Integrating a 3D Geological Model With the Hydro-Thermal Coupled Simulation
Authors: Huang Yonghui , Cheng Yuanzhi , Ren Lu , Tian Fei , Pan Sheng , Wang Ke , Wang Jianwei , Dong Yuexia , Kong Yanlong 
Published: January 2022

Assessment of available geothermal resources in the deep oil field is important to the synergy exploitation of oil and geothermal resources. A revised volumetric approach is proposed in this work for evaluating deep geothermal potential in an active oil field by integrating a 3D geological model into a hydrothermal (HT)-coupled numerical model. Based on the analysis of the geological data and geothermal conditions, a 3D geological model is established with respect to the study area, which is discretized into grids or elements represented in the geological model. An HT-coupled numerical model was applied based on the static geological model to approximate the natural-state model of the geothermal reservoir, where the thermal distribution information can be extracted. Then the geothermal resource in each small grid element is calculated using a volumetric method, and the overall geothermal resource of the reservoirs can be obtained by making an integration over each element of the geological model. A further parametric study is carried out to investigate the influence of oil and gas saturations on the overall heat resources. The 3D geological model can provide detailed information on the reservoir volume, while the HT natural-state numerical model addressed the temperature distribution in the reservoir by taking into account complex geological structures and contrast heterogeneity. Therefore, integrating the 3D geological modeling and HT numerical model into the geothermal resource assessment improved its accuracy and helped to identify the distribution map of the available geothermal resources, which indicate optimal locations for further development and utilization of the geothermal resources. The Caofeidian new town Jidong oil field serves as an example to depict the calculation workflow. The simulation results demonstrate in the Caofeidian new town geothermal reservoir that the total amount of geothermal resources, using the proposed calculation method, is found to be 1.23e+18 J, and the total geothermal fluid volume is 8.97e+8 m3. Moreover, this approach clearly identifies the regions with the highest potential for geothermal resources. We believe this approach provides an alternative method for geothermal potential assessment in oil fields, which can be also applied globally.
CO2 Mass Transfer and Oil Replacement Capacity in Fractured Shale Oil Reservoirs: From Laboratory to Field
Authors: Qiao Runwei , Li Fengxia , Zhang Shicheng , Wang Haibo , Wang Fei , Zhou Tong 
Published: January 2022

CO2-based fracturing is widely introduced to stimulate shale oil reservoirs for its multiple advantages. However, the range of CO2 entering the matrix around fractures and CO2-oil replacement capacity between matrix and fractures cannot be fully explained. To address this issue, a radial constant volume diffusion experiment on shale cores was designed in this study, and the pressure drop curve history was matched through numerical model to determine the composition effective diffusion coefficient. A field-scale numerical model was established, in which a series of certain grids were used to explicitly characterize fracture and quantify the prosess of CO2 mass transfer and oil replacement. Based on the field-scale numerical model, the process of shut-in, flow back, and oil production was simulated. The distribution of CO2 in fractured shale oil formation and its impact on crude oil during shut-in stage and flow back stage were investigated. This study concludes that CO2 gradually exchanges the oil in matrix into fractures and improve the fluidity of oil in matrix until the component concentrations of the whole reservoir reaches equilibrium during the shut-in process. Finally, about 30∼35 mole % of CO2 in fractures exchanges for oil in matrix. The range of CO2 entering the matrix around fractures is only 1.5 m, and oil in matrix beyond this distance will not be affected by CO2. During the process of flow back and production, the CO2 in fracture flows back quickly, but the CO2 in matrix is keeping dissolved in oil and will not be quickly produced. It is conclued that the longest possible shut-in time is conducive to making full use of the CO2-EOR mechanism in fractured shale oil reservoirs. However, due to the pursuit of economic value, a shut-in time of 10 days is the more suitable choice. This work can provide a better understanding of CO2 mass transfer mechanism in fractured shale oil reservoirs. It also provides a reference for the evaluation of the shut-in time and production management after CO2 fracturing.