bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Wave Telescope Technique
Authors: Narita Y. , Glassmeier K.‐H. , Motschmann U. 
Published: January 2022

AbstractUnambiguous determination of wavevectors (wavelengths and propagation directions) is one of the major challenges of space plasma observations, since conventional wave analysis methods for the single spacecraft data are limited to the time series data analysis and the wave properties are determined as a function of the frequencies in the spacecraft frame. The wave telescope technique overcomes the problem of wavevector determination by making extensive use of the multi‐spacecraft interferometric data. The wave telescope techniques do not assume any wave mode or plasma mode, and is suited to testing for the wave and turbulence theories against the multi‐spacecraft data. This article presents an updated report on the wave telescope technique on the basis of adaptive filtering (Capon's minimum variance projection), the construction of an estimator for the multi‐point magnetic field data, the performance and limits in the wavevector analysis (aliasing and low‐wavenumber behavior), the applications to the Cluster fluxgate magnetometer data (dispersion relations, phase velocity diagrams, propagation pattern, energy spectra, helicities, and higher‐order statistics), and possible extensions of the technique.
Loss of NFE2L3 protects against inflammation-induced colorectal cancer through modulation of the tumor microenvironment
Authors: Saliba James , Coutaud Baptiste , Makhani Kiran , Epstein Roth Noam , Jackson Jennie , Park Joo Yeoun , Gagnon Natascha , Costa Paolo , Jeyakumar Thiviya , Bury Marina , Beauchemin Nicole , Mann Koren K. , Blank Volker 
Published: January 2022

AbstractWe investigated the role of the NFE2L3 transcription factor in inflammation-induced colorectal cancer. Our studies revealed that Nfe2l3−/− mice exhibit significantly less inflammation in the colon, reduced tumor size and numbers, and skewed localization of tumors with a more pronounced decrease of tumors in the distal colon. CIBERSORT analysis of RNA-seq data from normal and tumor tissue predicted a reduction in mast cells in Nfe2l3−/− animals, which was confirmed by toluidine blue staining. Concomitantly, the transcript levels of Il33 and Rab27a, both important regulators of mast cells, were reduced and increased, respectively, in the colorectal tumors of Nfe2l3−/− mice. Furthermore, we validated NFE2L3 binding to the regulatory sequences of the IL33 and RAB27A loci in human colorectal carcinoma cells. Using digital spatial profiling, we found that Nfe2l3−/− mice presented elevated FOXP3 and immune checkpoint markers CTLA4, TIM3, and LAG3, suggesting an increase in Treg counts. Staining for CD3 and FOXP3 confirmed a significant increase in immunosuppressive Tregs in the colon of Nfe2l3−/− animals. Also, Human Microbiome Project (HMP2) data showed that NFE2L3 transcript levels are higher in the rectum of ulcerative colitis patients. The observed changes in the tumor microenvironment provide new insights into the molecular differences regarding colon cancer sidedness. This may be exploited for the treatment of early-onset colorectal cancer as this emerging subtype primarily displays distal/left-sided tumors.
Safety and activity of WX-0593 (Iruplinalkib) in patients with ALK- or ROS1-rearranged advanced non-small cell lung cancer: a phase 1 dose-escalation and dose-expansion trial
Authors: Shi Yuankai , Fang Jian , Hao Xuezhi , Zhang Shucai , Liu Yunpeng , Wang Lin , Chen Jianhua , Hu Yi , Hang Xiaosheng , Li Juan , Liu Chunling , Zhang Yiping , Wang Zhehai , Hu Yanping , Gu Kangsheng , Huang Jian’an , Zhang Liangming , Shan Jinlu , Ouyang Weiwei , Zhao Yanqiu , Zhuang Wu , Yu Yan , Zhao Jun , Zhang Helong , Lu Pei , Li Weidong , Si Meimei , Ge Mingjing , Geng Huaize 
Published: January 2022

AbstractWX-0593 (Iruplinalkib) is a novel, highly selective oral ALK and ROS1 tyrosine kinase inhibitor (TKI). In this study, the safety, antitumor activity, and pharmacokinetics of WX-0593 were evaluated in advanced non-small cell lung cancer (NSCLC) patients with ALK or ROS1 rearrangement. In the dose-escalation phase and dose-expansion phase, patients were treated with WX-0593 until disease progression, unacceptable toxicity, or subject withdrawal. In the dose-escalation phase, the primary endpoints were maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and safety assessed by investigators. In the dose-expansion phase, the primary endpoint was objective response rate (ORR) assessed by investigators. Between September 25, 2017 and October 15, 2018, a total of 153 patients received WX-0593 treatment. Two dose-limiting toxicities (DLTs) including one grade 3 QT interval prolonged and one grade 2 chronic heart failure were reported at the dose of 300 mg in one patient. MTD was not reached. Overall, 140 of the 152 (92%) patients experienced treatment-related adverse events (TRAEs) and 35 of the 152 (23%) patients had TRAEs ≥grade 3. The overall ORR was 59.3% (32 of 54) for the dose-escalation phase and 56.6% (56 of 99) for the dose-expansion phase. For patients who were ALK-rearranged and ALK TKI naive, the ORR were 81.0% (17 of 21) in the dose-escalation phase and 76.3% (29 of 38) in the dose-expansion phase, and for patients who previously received crizotinib as the only ALK TKI, the ORR were 38.1% (8 of 21) and 45.7% (21 of 46) for the two phases, respectively. For patients who were ROS1-rearranged, the ORR were 30.0% (3 of 10) in the dose-escalation phase and 44.4% (4 of 9) in the dose-expansion phase. WX-0593 showed favorable safety and promising antitumor activity in advanced NSCLC patients with ALK or ROS1 rearrangement.
Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients
Authors: Song Zhiqi , Bao Linlin , Deng Wei , Liu Jiangning , Ren Erjun , Lv Qi , Liu Mingya , Qi Feifei , Chen Ting , Deng Ran , Li Fengdi , Liu Yunpeng , Wei Qiang , Gao Hong , Yu Pin , Han Yunlin , Zhao Wenjie , Zheng Junjun , Liang Xujian , Yang Fuhe , Qin Chuan 
Published: January 2022

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted on mink farms between minks and humans in many countries. However, the systemic pathological features of SARS-CoV-2-infected minks are mostly unknown. Here, we demonstrated that minks were largely permissive to SARS-CoV-2, characterized by severe and diffuse alveolar damage, and lasted at least 14 days post inoculation (dpi). We first reported that infected minks displayed multiple organ-system lesions accompanied by an increased inflammatory response and widespread viral distribution in the cardiovascular, hepatobiliary, urinary, endocrine, digestive, and immune systems. The viral protein partially co-localized with activated Mac-2+ macrophages throughout the body. Moreover, we first found that the alterations in lipids and metabolites were correlated with the histological lesions in infected minks, especially at 6 dpi, and were similar to that of patients with severe and fatal COVID-19. Particularly, altered metabolic pathways, abnormal digestion, and absorption of vitamins, lipids, cholesterol, steroids, amino acids, and proteins, consistent with hepatic dysfunction, highlight metabolic and immune dysregulation. Enriched kynurenine in infected minks contributed to significant activation of the kynurenine pathway and was related to macrophage activation. Melatonin, which has significant anti-inflammatory and immunomodulating effects, was significantly downregulated at 6 dpi and displayed potential as a targeted medicine. Our data first illustrate systematic analyses of infected minks to recapitulate those observations in severe and fetal COVID-19 patients, delineating a useful animal model to mimic SARS-CoV-2-induced systematic and severe pathophysiological features and provide a reliable tool for the development of effective and targeted treatment strategies, vaccine research, and potential biomarkers.
The impact of the COVID-19 pandemic on oral health inequalities and access to oral healthcare in England
Authors: Stennett Michelle , Tsakos Georgios 
Published: January 2022

AbstractWhile the impact of the coronavirus disease (COVID-19) pandemic on health inequalities is documented, oral health has been absent from this discussion. This commentary highlights the potential impacts of the COVID-19 pandemic on oral health inequalities in England in February 2021. It includes a literature review, Public Health England and Kantar Worldpanel sales data on health behaviours and analysis of NHS dental services data. Purchasing data indicate, except for smoking, increases in health-compromising behaviours. Since the resumption of dental services, NHS general dental service use modestly recovered among adults but not children by October 2020. There are clear inequalities among children and older adults, with more deprived groups having lower uptake of dental service use than more affluent groups. Oral cancer referrals and hospital admissions for tooth extractions in children dramatically declined, with the latter primarily affecting children in more deprived areas. Many oral health programmes in schools and care homes were disrupted or suspended throughout this period. All these indicate that oral health inequalities have widened due to the COVID-19 pandemic. An oral health plan of action requires prioritising long-term investment in public health programmes and transforming commissioning pathways to support those with the greatest needs to access oral healthcare services.
From inputs to outputs: an analysis of the changes to learning outcomes for dental undergraduate education in the UK
Authors: Mather Helen , Bateman Heidi , Taylor John , Vernazza Christopher , Rothwell Charlotte , McCracken Giles , Ellis Janice 
Published: January 2022

AbstractIntroduction/aims Preparing for practice (PfP) was thought to represent a significant shift in the expectations of dental undergraduates compared to its predecessor, The first five years (TFFY). This project aimed to explore requirement changes by comparing learning outcomes for undergraduate dentists in these two documents. Changes in curriculum requirements defining clinical, professional, or a blend of these skills were also investigated.Methods Curriculum mapping was used to compare learning outcomes in PfP to requirements in TFFY.Results The total number of learning outcomes increased from 101 to 149 in PfP compared to TFFY. There was a proportional reduction in outcomes describing clinical skills and an increase in the proportion of outcomes describing professional and blended skills. Three TFFY requirements did not appear in PfP and a further 23 learning outcomes in PfP were absent in TFFY.Conclusions In the transition from TFFY to PfP, there has been an overall increase in the number of outcomes graduates must attain before they can register with the General Dental Council. There are more outcomes defining professionalism which subsequently has resulted in proportional but not actual decrease in outcomes related to clinical skills. While there is uncertainty over how schools have managed curricula to incorporate these changes and thus whether the perception of graduate preparedness can be directly attributable to these changes, it is timely to consider any changes within dental learning outcomes in the context of preparedness concerns.
LncRNA XR_596701 protects H9c2 cells against intermittent hypoxia-induced injury through regulation of the miR-344b-5p/FAIM3 axis
Authors: Chen Qingshi , Lin Guofu , Lin Lanlan , Huang Jiefeng , Chen Lida , Lian Ningfang , Chen Mengxue , Zeng Aiming , Lin Qichang 
Published: January 2022

AbstractLong noncoding RNAs (lncRNAs) participate in various biological processes and cardiovascular diseases. Recently, a novel lncRNA XR_596701 was found to be differentially expressed in obstructive sleep apnea (OSA)-induced myocardial tissue compared to normal myocardial tissues. However, the pathological effect and regulatory mechanism of XR_596701 in intermittent hypoxia (IH)-mediated cardiomyocytes damage have not been studied. The subcellular localization of XR_596701 was determined by fluorescence in situ hybridization (FISH). Gene expressions of XR_596701 and miR-344b-5p were detected by quantitative real-time polymerase chain reaction (qRT-PCR) in IH-induced H9c2 cells. Cell proliferation was measured by 5-ethynyl-2′-deoxyuridine (EdU) staining assay. Cell apoptosis was detected by Hoechst 33342/PI staining and immunofluorescence (IF). Apoptotic protein of H9c2 cells was measured by western blot. The direct interaction between XR_596701 and miR-344b-5p as well as miR-344b-5p and Fas apoptotic inhibitory molecule 3 (FAIM3) were examined using dual-luciferase reporter assay. The significance of XR_596701 and miR-344b-5p on cell proliferation and apoptosis was evaluated by using gain-of-function and loss-of-function approaches. XR_596701 was upregulated, while miR-344b-5p downregulated in IH-induced H9c2 cells. Functionally, suppression of XR_596701 and overexpression of miR-344b-5p inhibited cell proliferation and promoted cell apoptosis in H9c2 cells. The roles of XR_596701 were achieved by sponging miR-344b-5p. And the function of miR-344b-5p was reversed by targeting FAIM3. Additionally, FAIM3 mediated IH-induced H9c2 cells damage by XR_596701. XR_596701 was serve as a novel lncRNA that indicated protective roles on proliferation and apoptosis of IH-induced H9c2 cells through the miR-344b-5p/FAIM3 axis.
Optical detection of the density-wave instability in the kagome metal KV3Sb5
Authors: Uykur Ece , Ortiz Brenden R. , Wilson Stephen D. , Dressel Martin , Tsirlin Alexander A. 
Published: January 2022

AbstractCoexisting density-wave and superconducting states along with the large anomalous Hall effect in the absence of local magnetism remain intriguing and enigmatic features of the AV3Sb5 kagome metals (A = K, Rb, Cs). Here, we demonstrate via optical spectroscopy and density-functional calculations that low-energy dynamics of KV3Sb5 is characterized by unconventional localized carriers, which are strongly renormalized across the density-wave transition and indicative of electronic correlations. Strong phonon anomalies are prominent not only below the density-wave transition, but also at high temperatures, suggesting an intricate interplay of phonons with the underlying electronic structure. We further propose the star-of-David and tri-hexagon (inverse star-of-David) configurations for the density-wave order in KV3Sb5. These configurations are strongly reminiscent of p-wave states expected in the Hubbard model on the kagome lattice at the filling level of the van Hove singularity. The proximity to this regime should have intriguing and far-reaching implications for the physics of KV3Sb5 and related materials.
Integrated molecular and behavioural data reveal deep circadian disruption in response to artificial light at night in male Great tits (Parus major)
Authors: Dominoni Davide M. , de Jong Maaike , van Oers Kees , O’Shaughnessy Peter , Blackburn Gavin J. , Atema Els , Mateman A. Christa , D’Amelio Pietro B. , Trost Lisa , Bellingham Michelle , Clark Jessica , Visser Marcel E. , Helm Barbara 
Published: January 2022

AbstractGlobally increasing levels of artificial light at night (ALAN) are associated with shifting rhythms of behaviour in many wild species. However, it is unclear whether changes in behavioural timing are paralleled by consistent shifts in the molecular clock and its associated physiological pathways. Inconsistent shifts between behavioural and molecular rhythms, and between different tissues and physiological systems, disrupt the circadian system, which coordinates all major body functions. We therefore compared behavioural, transcriptional and metabolomic responses of captive great tits (Parus major) to three ALAN intensities or to dark nights, recording activity and sampling brain, liver, spleen and blood at mid-day and midnight. ALAN advanced wake-up time, and this shift was paralleled by advanced expression of the clock gene BMAL1 in all tissues, suggesting close links between behaviour and clock gene expression across tissues. However, further analysis of gene expression and metabolites revealed that clock shifts were inconsistent across physiological systems. Untargeted metabolomic profiling showed that only 9.7% of the 755 analysed metabolites followed the behavioural shift. This high level of desynchronization indicates that ALAN disrupted the circadian system on a deep, easily overlooked level. Thus, circadian disruption could be a key mediator of health impacts of ALAN on wild animals.
Reduced rainfall and resistant varieties mediate a critical transition in the coffee rust disease
Authors: Li Kevin , Hajian-Forooshani Zachary , Su Chenyang , Perfecto Ivette , Vandermeer John 
Published: January 2022

AbstractCritical transitions, sudden responses to slow changes in environmental drivers, are inherent in many dynamic processes, prompting a search for early warning signals. We apply this framework to understanding the coffee rust disease, which experienced an unprecedented outbreak in Mesoamerica in 2012–2013, likely a critical transition. Based on monthly infection data from 128 study quadrats in a 45-ha plot in southern Mexico from 2014 to 2020, we find that the persistent seasonal epidemic following the initial outbreak collapses in an evident subsequent critical transition. Characteristic signals of “critical slowing down” precede this collapse and are correlated with reduced rainfall, as expected from climate change, and planting of rust-resistant varieties, an ongoing management intervention. Recoveries from catastrophes may themselves be experienced as a critical transition and managers should consider the larger dynamical landscape for the possibility of subsequent transitions. Early warning signals could therefore be useful when evaluating mitigation effectiveness.
Age-adjusted interpretation of biomarkers of renal function and homeostasis, inflammation, and circulation in Emergency Department patients
Authors: Candel Bart G. J. , Khoudja Jamèl , Gaakeer Menno I. , ter Avest Ewoud , Sir Özcan , Lameijer Heleen , Hessels Roger A. P. A. , Reijnen Resi , van Zwet Erik , de Jonge Evert , de Groot Bas 
Published: January 2022

AbstractAppropriate interpretation of blood tests is important for risk stratification and guidelines used in the Emergency Department (ED) (such as SIRS or CURB-65). The impact of abnormal blood test values on mortality may change with increasing age due to (patho)-physiologic changes. The aim of this study was therefore to assess the effect of age on the case-mix adjusted association between biomarkers of renal function and homeostasis, inflammation and circulation and in-hospital mortality. This observational multi-center cohort study has used the Netherlands Emergency department Evaluation Database (NEED), including all consecutive ED patients ≥ 18 years of three hospitals. A generalized additive logistic regression model was used to visualize the association between in-hospital mortality, age and five blood tests (creatinine, sodium, leukocytes, C-reactive Protein, and hemoglobin). Multivariable logistic regression analyses were used to assess the association between the number of abnormal blood test values and mortality per age category (18–50; 51–65; 66–80; > 80 years). Of the 94,974 included patients, 2550 (2.7%) patients died in-hospital. Mortality increased gradually for C-reactive Protein (CRP), and had a U-shaped association for creatinine, sodium, leukocytes, and hemoglobin. Age significantly affected the associations of all studied blood tests except in leukocytes. In addition, with increasing age categories, case-mix adjusted mortality increased with the number of abnormal blood tests. In summary, the association between blood tests and (adjusted) mortality depends on age. Mortality increases gradually or in a U-shaped manner with increasing blood test values. Age-adjusted numerical scores may improve risk stratification. Our results have implications for interpretation of blood tests and their use in risk stratification tools and acute care guidelines.Trial registration number Netherlands Trial Register (NTR) NL8422, 03/2020.
Inner wall temperature distribution measurement of the ladle based on cavity effective emissivity correction
Authors: Liu Jun , Huang Yan-hui , Ci Ying , Fang Jiang-xiong , Yang Feng , David Nobes 
Published: January 2022

AbstractInner wall temperature of ladle is closely related to the quality of steelmaking and control of steel-making tapping temperature. This article adopts a rotating platform to drive an infrared temperature sensor and a laser sensor to scan the temperature field distribution of the ladle inner wall at the hot repair station, where the scanning laser sensor obtains coordinates of each measured point. Because of measuring errors of infrared thermal radiation caused by emissivity uncertainty of the ladle inner wall surface, this article proposes a method for temperature measurement based on Monte Carlo model for effective emissivity correction of each measured point. In the model, we consider the ladle and fire baffle as a cavity. By calculation of the model, the effect of distance from the fire baffle to the ladle and the material surface emissivity of the ladle inner wall on the effective emissivity of the cavity are obtained. After that, the effective emissivity of each measured point is determined. Then the scanning temperature of each measured point is corrected to real temperature. By field measuring test and verification contrast, the results show that: the maximum absolute error of the method in this article is 4.7 °C, the minimum error is 0.6 °C, and the average error is less than 2.8 °C. The method in this article achieves high measurement accuracy and contributes to the control of metallurgical process based on temperature information.
The mediating roles of demand and satisfaction in formation process of physical exercise habits among college students
Authors: Wang Kun , Qian Jiali , Yang Jiayi , Ge Tianyi , Li Zhizhong 
Published: January 2022

AbstractConsidering the situation and disadvantages of being physically inactive as well as the nature and advantages of doing physical exercise regularly, there is a need to explore how physical exercise habits are cultivated and formed. The study was to examine the formation process of physical exercise habits. According to the Model of Physical Exercise and Habit, It was speculated that satisfaction, demand or chain from satisfaction to demand could mediate the relationship between physical exercise behavior and physical exercise habit. Cross-sectional design with 3202 college or university students from China was employed. Data about physical exercise habits, physical exercise behaviors as well as related questions was measured by the Self-Report Exercise Habits Index and direct questions. Structural Equation Modeling (SEM) was constructed to evaluate the mediating effects of demand and/or satisfaction by Asymptotically Distribution-Free and BOOTSTRAP. The inferential statistics was to estimate path coefficient and mediation effect. Findings suggested physical exercise behaviors could develop into physical exercise habits through a direct path, single mediators of demand or satisfaction, or a chain mediator from demand to satisfaction.