bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seven Epileptic Seizure Type Classification in Pre-Ictal, Ictal and Inter-Ictal Stages Using Machine Learning Techniques
Authors: Dutta Kusumika Krori , Manohar Premila , K Indira , Naaz Falalk , Lakhminarayanan Meenakshi , Rajagopalan Shwethaa 
Published: October 2022

Abstract
Background
Based on the symptoms experienced during the episode and the Electroencephalograph (EEG) recording made during the inter-ictal phase, the doctor makes the epileptic seizure type diagnosis. The fundamental issue, however, is that patients frequently struggle to explain their symptoms in the absence of an observer and identify traces in inter-ictal EEG patterns.
Aims
This study examines electroencephalographic (EEG) signals from epileptic seizures in order to diagnose seizures in pre-ictal, ictal, and inter-ictal stages and to categorize them into seven groups.
Methods
For the investigation, a licensed dataset from Temple University Hospital was used. Seven different seizure types are pre-processed from the seizure corpus and divided into pre-ictal, ictal, and inter-ictal stages. K-Nearest Neighbor (KNN), Random Forest, and other machine and deep learning techniques were used to perform the multi-class categorization.
Result
With 20 channels and an 80 − 20 train-test ratio, multiclass classification of seven different types of epileptic seizures was accomplished. For the pre-ictal, ictal, and inter-ictal stages, weighted KNN achieved accuracy levels of 94.7%, 94.7%, 69.0% during training and 94.46%, 94.46%, and 71.11% during testing.
Conclusion
Seven epileptic seizure type classification using machine learning techniques carried out with MATLAB software and weighted KNN shows better accuracy comparatively.
Early evolutionary branching across spatial domains predisposes to clonal replacement under chemotherapy in neuroblastoma
Authors: Gisselsson David , Karlsson Jenny , Yasui Hiroaki , Manas Adriana , Andersson Natalie , Hansson Karin , Aaltonen Kristina , Jansson Caroline , Durand Geoffroy , Yang Minjun , Chattopadhyay Subhayan , Paulsson Kajsa , Spierings Diana , Foijer Floris , Valind Anders , Bexell Daniel 
Published: October 2022

Abstract

Neuroblastoma (NB) is one of the most lethal childhood cancers due its propensity to treatment resistance. By spatial mapping of subclone geographies before and after chemotherapy across 89 tumor regions from 12 NBs, we find that densely packed territories of closely related subclones present at diagnosis are replaced under effective treatment by islands of distantly related survivor subclones, originating from a different most recent ancestor compared to lineages dominating before treatment. Conversely, in tumors that progressed under treatment, ancestors of subclones dominating later in disease are present already at diagnosis. Chemotherapy treated xenografts and cell culture models replicates these two contrasting scenarios and shows branching evolution to be a constant feature of proliferating NB cells. Phylogenies based on whole genome sequencing of 505 individual NB cells indicate that a rich repertoire of parallel subclones, emerges already with the first oncogenic mutations and lays the foundation for clonal replacement under treatment.
The synthesis and use of α-cellulose and cationic cellulose from Boehmeria nivea as bio-flocculants in flocculation of kaolin suspension
Authors: Fauzani Dinda , Notodarmojo Suprihanto , Handajani Marisa , Helmy Qomarudin , Kardiansyah Teddy 
Published: October 2022

Abstract

The synthesis and modification of α-cellulose from Boehmeria nivea into a cationic bioflocculant was performed. In the first stage of research, α-cellulose was isolated from the bast fiber of Boehmeria nivea. Second, the modification of α-cellulose into cationic cellulose was carried out by reaction using 3-chloro-2-hydroxypropyl-trimethylammonium chloride (CHPTAC). α-cellulose and cationic cellulose were tested as bioflocculants for their flocculation ability with synthetic water samples using 5 g/L of kaolin suspension with turbidity as the test parameter. Data analysis was performed by statistical analysis using one-way ANOVA and Duncan's multiple range test. Studies showed that the use of α-cellulose as a bioflocculant in the coagulation-flocculation process with polyaluminum chloride (PAC) as a coagulant statistically increased the efficiency of turbidity removal, up to 99.17%, whereas the direct flocculation process, i.e., without the use of coagulant, had a turbidity removal efficiency of 98.91% with 60 minutes of sedimentation time. The use of cationic cellulose showed promising results as a bioflocculant in the direct flocculation process compared to PAC, with a shorter sedimentation time.
Novel lncRNA-miRNA-mRNA Competing Endogenous RNA Triple Networks Associated Programmed Cell Death in atherosclerosis
Authors: Fan Jilin , Zhu Tingting , Tian Xiaoling , Liu Sijia , Zhang Shiliang 
Published: October 2022

Abstract
Objective: Atherosclerosis (AS) is the main pathological basis of most cardiovascular diseases, numerous studies have shown that programmed cell death and lncRNA-miRNA-mRNA regulatory network play an important role in cardiovascular diseases. However, the crosstalk between the ceRNA network associated with programmed cell death and AS remains unclear. This article aims to explore the role of programmed cell death-related ceRNA network in the pathophysiological process of AS, in order to provide new targets for the diagnosis and treatment of AS.:
Methods: Firstly, the GSE97210 and GSE28858 datasets were screened from the GEO database, and the differentially expressed lncRNA, mRNA and miRNA were screened, and then the lncRNA-miRNA-mRNA regulatory network was constructed in Cytoscape 3.7.2 software based on ceRNA theory. Second, GO and KEGG enrichment analysis of mRNA in the ceRNA network was performed. Finally, the mRNAs in the ceRNA network were intersected with genes related to autophagy, pyroptosis and ferroptosis to construct a ceRNA network related to programmed cell death:
Results: According to the results of bioinformatics analysis, a total of 1208 DElncRNAs, 4723 DEmRNAs and 139 DEmiRNAs were obtained. A ceRNA network consisting of 64 lncRNAs, 8 miRNAs and 167 mRNAs was constructed. The mRNAs in the CeRNA network are mainly enriched in biological functions such as positive regulation of transcription and migration, protein binding, GTPase activity, and signaling pathways such as PI3K-Akt signaling pathway, ErbB signaling pathway, and mTOR signaling pathway. Validated by receiver operating characteristic (ROC) curves, 7 lncRNA-mediated ceRNA regulatory pathways for pyroptosis and 23 lncRNA-mediated regulatory pathways for ferroptosis and autophagy were constructed.:
Conclusion: This study screened and identified the lncRNA, miRNA and mRNA expression profiles specifically expressed in AS tissues based on bioinformatics analysis, and constructed a ceRNA network related to programmed cell death, which is helpful for us to understand that programmed cell death leads to AS The mechanism of action, while providing new insights into programmed cell death in AS.:
Outcomes of fatty liver disease with and without metabolic comorbidities and risk factors for mortality
Authors: Ogasawara Yuri , Kogiso Tomomi , Horiuchi Kentaro , Taniai Makiko , Tokushige Katsutoshi 
Published: October 2022

Abstract
Aims
Patients with fatty liver disease (FLD) frequently have metabolic risk factors; however, the clinical course of metabolic-associated FLD (MAFLD) in Asians is unclear. We compared the clinical courses of MAFLD and nonalcoholic FLD (NAFLD).
Methods
Asian FLD patients (n = 987) from 1991–2021 (biopsy-proven in 939, 497 males) were enrolled. The patients were divided into non-MAFLD/NAFLD (non-M/N, n = 92), both M/N (n = 785), and M/non-N (n = 90) groups. The clinical features, complications, and survival rates were compared among the three groups. Mortality risk factors were subjected to Cox regression analysis.
Results
1) Non-M/N patients were significantly younger (non-M/N, M/N, and M/non-N 50, 53, and 57 years, respectively), more frequently male (54.3, 52.6, and 37.8%), and had a low body mass index (BMI, 23.1, 27.1, and 26.7 kg/m2) and FIB-4 index (1.20, 1.46, and 2.10). Hypopituitarism (5.4%) and hypothyroidism (7.6%) were significantly observed in the non-M/N group. Hepatocellular carcinoma (HCC) developed in 0.0, 4.2, and 3.3% of the cases, and extrahepatic malignancies in 6.8, 8.4, and 4.7% of the cases, respectively, with no significant differences. The cardiovascular event rate was significantly higher in the M/non-N group (1, 37, and 11 cases, p < 0.01). Survival rates were not significantly different among the three groups. 2) The risk factors for mortality were age and BMI in the non-M/N group; age, HCC, alanine transaminase, and FIB-4 in the M/N group; and FIB-4 in the M/non-N group.
Conclusions
Although there was no significant difference in survival rates among the three groups of FLD, it should be considered that there would be different risk factors for mortality among the groups.
Two Steps Forwards, One Step Back? Party Competition, Cooperative Federalism, and Transport Policy Reforms in Germany
Authors: Souris Antonios , Stecker Christian , Jungjohann Arne 
Published: October 2022

Abstract

Background
As part of the Verkehrswende, the extensive transition towards sustainable transport and mobility in Germany, the federal government proposed the reform of two key ordinances to implement provisions at the expense of car drivers and, at the same time, in favor of cycling and walking. Due to cooperative federalism, the Bundesrat as the de facto second chamber had to adopt the reform. In the legislative process, the reform ultimately failed in its original scope. Using it as a particularly instructive case study, we show how and why party competition and cooperative federalism hamper comprehensive transport policy reforms in Germany.
Results
Based on our process-tracing approach, we find that political parties make use of their power in the Bundesrat to influence legislative procedures in accordance with their agenda. Moreover, the political majority constellations in the Bundesrat hinder major transportation reforms and allow for only incremental steps based on the lowest common denominator among decision-makers.
Conclusions
The case study provides novel empirical evidence for a ‘traditional’ critique of cooperative federalism in Germany, namely that it is prone to blockades and hence political standstill if partisan encroach on federal decision-making. Transport policy has become re-politicized in German party competition. Compromises on the lowest common denominator thwart major reforms and allow for only incremental change.
A Hybrid CUDA, OpenMP, and MPI parallel TCA-based Domain Adaptation for Classification of Very High-Resolution Remote Sensing Images
Authors: Garea Alberto Suarez , Heras Dora Blanco , Pedreira Francisco Arguello , Demir Begüm 
Published: October 2022

Abstract
Domain Adaptation (DA) is a technique that aims at extracting information from a labeled remote sensing image to allow classifying a different image obtained by the same sensor but at a different geographical location. This is a very complex problem from the computational point of view, specially due to the very high-resolution multispectral images. TCANet is a deep learning neural network for DA classification problems that has been proven as very accurate for solving it. TCANet consists of several stages based on the application of convolutional filters obtained through Transfer Component Analysis (TCA) computed over the input images. It does not require training, in contrast to the usual CNN-based networks. In this paper, a hybrid parallel TCA-based domain adaptation technique for solving the classification of very high-resolution multispectral images is presented. It is designed for efficient execution on a multi-node computer by using message passing interface (MPI), exploiting the available Graphical Processing Units (GPUs), and making efficient use of each multicore node by using Open Multiprocessing (OpenMP). As a result, an accurate DA technique from the point of view of classification and with high speedup values over the sequential version is obtained, increasing the applicability of the technique to real problems.
Study on strength characteristics and failure mechanism of hard rock containing cracks with different dip angles
Authors: jia baoxin , liu fengpu , chen guodong 
Published: October 2022

Abstract
To further study the strength characteristics and failure mechanism of hard rock containing open prefabricated cracks, uniaxial compression tests of green sandstone containing open prefabricated cracks of different inclination angles were carried out. The results show that the peak strength of the unclosed prefabricated cracked green sandstone is lower than that of the intact green sandstone, and the peak strength increases and then decreases with increasing β, with the highest strength at β = 75 and the lowest strength at β = 0.The characteristics of acoustic emission (AE) signals are roughly divided into two stages a stable period and an active period. When 0 ≤ β ≤ 30, the proportion of the active period is large; when 45 ≤ β ≤ 90, the proportion of the active period is small. When β increases from 0 to 90, the failure modes mainly include four types, which are slab crack failure caused by tensile stress, type I tensile failure caused by type II shear stress, shear failure along the shear slip surface and splitting failure caused by tensile stress. When β = 0, 15,a small-scale strain burst occurs, and the ejected fragments are of medium size and in the shape of 'plate'. When β = 30,45, the ejection of local small fragments occurs. When β = 60, 75, a high-strength strain burst dominated by large fragments occurs. When β = 90, the rock is mostly stripped on the surface without obvious rockburst.
Outpatient management of acute uncomplicated appendicitis after laparoscopic appendectomy – A Randomized Controlled Trial
Authors: Lopez Jordi Elvira , Mallafré Ricard Sales , Zegarra Erlinda Padilla , Luna Luis Carrillo , Serafini Joan Ferreres , Tully Roisin , Ikuga Robert Memba , Martin Rosa Jorba 
Published: October 2022

Abstract

Objective: To confirm the safety and efficacy of outpatient management of laparoscopic appendectomy, with an Enhanced Recovery After Surgery (ERAS) protocol, in adult patients with uncomplicated acute appendicitis. Summary Background Data: Outpatient laparoscopic appendectomy is feasible and secure in selected patients in observational studies. The benefits include reduced length of stay (LOS) and post-operative complications. This is the first Randomized Controlled Trial (RCT) of outpatient management following ERAS protocol.
Methods: Patients admitted from the emergency department with acute appendicitis randomized into one of two groups. Standard care within the hospital (HG) or the outpatient group (OG). An ERAS protocol was followed for both groups. Patients in the HG were admitted to the surgical ward. Patients in the OG were referred to the day-surgery unit. The primary endpoint was length of stay.
Results: Ninety-seven patients were included, 49 in the OG and 48 in the HG. LOS was significantly shorter in the OG (mean 8.82h) than the HG (mean 43.53h), p<0.001. There was no difference in readmission rates (p = 0.320), we observed only one readmission in the OG. No further emergency consultations or complications were observed. The cost saving was $516.52/patient as a result of the intervention.
Conclusion: Outpatient management of appendectomy is safe and feasible procedure in selected patients. This approach could become the standard of care for patients with uncomplicated appendicitis, showing fewer complications, lower LOS and cost. Trial registration: Clinical Trial ID: NCT05401188 Keywords: Appendicitis, Acute Appendicitis, uncomplicated Acute Appendicitis, outpatient management, laparoscopic appendectomy, ERAS protocol
Warm and harsh parenting, self-kindness and self-judgment, adolescent well-being: An examination of developmental differences
Authors: Ren Yizhen , Bu He , Huang Liuyue , Wang Shaofan , Zhang Ying , Zeng Di , Shan Hao , Chi Xinli 
Published: October 2022

Abstract
Objectives
This study aimed to examine the associations between warm and harsh parenting and adolescent well-being and the mediating effects of self-kindness and self-judgment in the relationships. Moreover, this study investigated different developmental across three adolescence stages (early, middle, and late).
Methods
Totally 14776 Chinese adolescents (mean age = 13.53 ± 2.08, 52.3% males) participated in this study. All adolescents rated the levels of warm parenting and harsh parenting, self-kindness and self-judgment, and well-being.
Results
Both warm and harsh parenting were related to adolescent well-being through the mediating effects of self-kindness and self-judgment. But warm parenting exerted a more substantial impact on adolescent well-being. Self-kindness demonstrated a more robust mediating effect compared to self-judgment in the relationships. Moreover, harsh parenting in late adolescence had a weaker impact on adolescent well-being than those in early and middle adolescence. Warm parenting had a more significant impact on adolescent well-being in early adolescence than in middle and late adolescence.
Conclusions
Overall, warm parenting had a more substantial effect on adolescent well-being than harsh parenting. The findings also highlighted the crucial mediating effect of self-kindness in the relationships between parenting and adolescent well-being. Moreover, this study also indicated the importance of warm parenting in early adolescence.
Analysis of clinical factors in olaparib-related anemia using adverse drug event reporting databases
Authors: Shiraishi Chihiro , Hirai Toshinori , Ogura Toru , Iwamoto Takuya 
Published: October 2022

Abstract

Purpose: Anemia is one of the dose-limiting toxicities of olaparib. The global phase Ⅲ trial confirmed that anemia occurrence in Japanese was relatively high. The factors related to anemia in different nationalities remain unknown. Therefore, this study investigated the factors of olaparib-related anemia in real-world settings using an adverse event reporting system database.
Methods: We used data from FDA Adverse Events Reporting System (FAERS) and Japanese Adverse Drug Event Report database (JADER) between 2018 and 2021. FAERS reports from Japan were collected to conduct subgroup analyses, which was defined as FAERS-Japan. The endpoint was the occurrence of olaparib-related anemia. Disproportionality analysis was conducted to calculate reporting odds ratio (ROR), with a confidence interval of 95%. Adjusted ROR (aROR) was calculated to control for gender differences.
Results: In FAERS and JADER, the daily olaparib dose per body weight (DPBW) ≥12 mg/kg was detected to be a positive signal for anemia occurrence (aROR; FAERS, 4.483 [3.009–6.680], p<0.001, FAERS-Japan, 1.834 [1.091–3.063], p=0.009, and JADER, 1.628 [1.039–2.551], p=0.034). Furthermore, FAERS reports confirmed that females with body weight <50kg, reports from Japan, concomitant use of drugs suppressing vitamin B12, and previous platinum treatment history were positive signals of olaparib-related anemia. FAERS-Japan also showed that body weight <50kg and previous platinum treatment history were positive signals for the anemia occurrence.
Conclusion: High DPBW poses a significant risk of anemia. The co-administration of drugs suppressing vitamin B12 and previous platinum treatment history are also important information to evaluate the risk of olaparib-related anemia.
Convective Drying of Chokeberry (Aronia melanocarpa Michx. Elliot)) cv. ‘Viking’
Authors: Suslu Ahmet , Kulcu Recep , Dincer Cuneyt , Yavuzlar Eda Elif , Ertekin Can , Unal Nafiye 
Published: October 2022

Abstract

The effects of drying air temperatures (50, 60, 70 and 80°C) and velocities (0.5, 0.8, 1.2 m.s− 1) used for the convective drying of chokeberry on fruit quality were quantified. The drying air temperature rise shortened the drying time from 2660 min at 50 oC to 185 min at 80 oC. Drying time was 220 min at the drying air velocity of 1.2 m.s− 1. An increase in the temperature from 50 to 80°C and the air velocity from 0.5 m·s− 1 to 1.2 m·s− 1 enhanced fruit color quality index. All the drying treatments enriched the biochemical fruit content. 70°C and the air velocity between 0.5 m.s− 1 and 1.2 m.s− 1 achieved the highest antioxidant activity, total anthocyanin content and total phenolic content.
The relevance of fish in the summer diet of the Antarctic fur seal (Arctocephalus gazella) at Hope Bay, Antarctic Peninsula and Stranger Point, South Shetland Islands
Authors: Descalzo Mariana , Daneri Gustavo A. , Harrington Ana , Negrete Javier , Negri Agustina , Corbalán Aldo , Barrera-Oro Esteban 
Published: October 2022

Abstract

The fish incidence, particularly notothenioids and myctophids, in the diet of non-breeding male Arctocephalus gazella in the western Antarctic Peninsula (AP) region is scarcely known. We made a comparative diet analysis on 158 faecal samples collected in summer 2005 at Hope Bay (HB), AP and at Stranger Point (SP), South Shetland Islands (SSI). The occurrence of Antarctic krill Euphausia superba and fish as prey was similar at HB, whereas krill was predominant at SP. For each fish species identified based on the otoliths found, their relative importance in the diet was evaluated using the IRI index. Notothenioid fish prevailed at HB: Pleuragramma.antarctica was the most important prey followed by Chaenodraco wilsoni. Contrarily, myctophids predominated at SP: Gymnoscopelus nicholsiand Electrona antarctica were the dominant prey. Both benthopelagic and pelagic fish species were represented at HB, while the latter were more important at SP; we suggest that seals from SP are foraging in pelagic strata, while at HB their habitat includes benthic and pelagic environments. Demersal nototheniid species were scarcely represented and only at HB, which might be related to a preference of fur seals on the more abundant pelagic prey there. At SP, the absence of demersal nototheniid otoliths in the faeces could be linked to the historical finfish fisheries that took place in the SSI area. On fish species consumption, there was a higher diversity at SP in comparison with HB but a low overlap between these sites. Our findings are compared with studies from localities of the AP and the Scotia Arc.