bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Development of German Monologies in the Pandemic Time Based on Short Stories into Prose Anthologies as Teaching Materials of German Literature
Authors: Harahap Ahmad Bengar , Hafniati  , Aini Indah 
Published: October 2022

Monologue is a literary work that is included as a prose study which was created not only to be understood, but more than that monologue must be enjoyed, lived and interpreted. The study of monologue is part of literary learning that can be performed in a stage or performance through the process of show a single drama with various sources as a script, one of which is a short story. During the current phenomenal Covid 19 pandemic, the impact is very significant in affecting all aspects of life, but there are many prose literary works that can be performed by literary actors, including students, in appreciating the pandemic atmosphere. Short stories in German literature can be performed through monologue performances both online and offline as a concept for the study of prose studies during a pandemic. The output can produce an anthology of monologues as an interesting prose literature teaching material to be discussed and investigated in research. Therefore, this study aims to; (1) to develop teaching materials for German literature or literature to improve the skills of German-language students in prose studies, (2) to become learning models or practical learning models in German literature or literature courses. The model used in this study is Model Richey and Klein (2007). From the results of the research, it will be obtained that the German monologue anthology book during the covid19 pandemic time as teaching materials and digital media for learning literary practice and its output also becomes an indexed journal article or proceedings on a national and international scale.
OMNICHANNEL: UM ESTUDO EM CAÇADOR/SC
Authors: Moreira Fernando , Hupalo Leandro 
Published: October 2022

A emergência nas novas formas de chegar ao consumidor e os novos modelos organizacionais faz com que as organizações cada vez mais passem a buscar novas formas de evidenciar os seus produtos e serviços elaborando estratégias na área de vendas. O presente estudo tem como objetivo geral analisar os impactos da prática do omnichannel nas relações de consumo no município de Caçador/SC. Como objetivos específicos apresentam-se: (a) identificar o perfil do consumidor; (b) identificar o canal padrão de consumo; e (c) identificar os impactos nas relações de consumo. O estudo caracteriza-se como predominantemente quantitativo quanto à sua abordagem, como uma pesquisa aplicada em relação à sua natureza, possui características de pesquisa descritiva quanto aos seus objetivos e, em relação aos procedimentos, trata-se de uma pesquisa de levantamento. As análises apontam para um público com pré-disposição para o comércio online, sobretudo, em virtude da qualidade, variedade e preço competitivo em relação ao comércio físico.
Palavras-Chave: Consumidor. Globalização. Marketing. Vendas.

Abstract: The emergence of new ways of reaching the consumer and the new organizational models makes organizations increasingly look for new ways to highlight their products and services by developing strategies in the sales area. The present study has the general objective of analyzing the impacts of the omnichannel practice on consumer relations in the city of Caçador/SC. The specific objectives are: (a) to identify the consumer's profile; (b) identify the standard consumption channel; and (c) identify the impacts on consumer relations. The study is characterized as predominantly quantitative in its approach, as an applied research in relation to its nature, it has characteristics of a descriptive research in relation to its objectives and, in relation to the procedures, it is a survey research. The analyzes point to a public with a predisposition for online commerce, mainly due to the quality, variety and competitive price in relation to physical commerce.
Keywords: Consumer. Globalization. Marketing. Sales.
Pelatihan dan Sosialisasi Penanggulangan Bencana Alam Bagi Guru PJOK MGMP Kabupaten Seluma
Authors: Sugihartono Tono , Nevitasari Dwi , Yarmani Yarmani 
Published: October 2022

Ancaman bencana alam di Bengkulu mulai dari banjir, tanah longsor, cuaca ekstrem, gelombang ekstrem dan abrasi, gempa bumi, kebakaran hutan, kekeringan, letusan gunung, dan tsunami. Berkaitan dengan kondisi wilayah tersebut, masyarakat Bengkulu sebaiknya mempunyai sikap, pengetahuan, dan keterampilan dalam menghadapi bencana alam, sehingga resiko secara moril maupun materil yang ditanggung masyarakat menjadi rendah. Maka, perlu diadakan pelatihan dan sosialisasi penanggulangan bencana alam bagi guru PJOK MGMP kabupaten Seluma. Tujuan dari kegiatan ini adalah memberikan pengetahuan, dan keterampilan bagi guru PJOK MGMP kabupaten Seluma sehingga akan terbentuk sikap tanggap dalam penanggulangan bencana alam. Kegiatan pelatihan dan sosialisasi dilaksanakan di SMP Negeri 1 Seluma yang beralamat di Jalan Pajar Bulan, Semidang Alas, Kabupaten Seluma, Bengkulu. Mitra dalam kegiatan ini adalah guru PJOK MGMP Kabupaten Seluma, yang berjumlah 20 guru PJOK. Kegiatan ini dilaksanakan pada 12 Oktober 2019. Bentuk kegiatan yang dilakukan adalah sosialisasi dan pelatihan. Kegiatan ini dilakukan dengan model ceramah, small group discussion, dan pelatihan. Berdasarkan hasil kegiatan dapat disimpulkan bahwa pelatihan dan sosialisasi penanggulangan bencana alam bagi guru PJOK MGMP kabupaten Seluma dapat meningkatkan pengetahuana dan keterampilan peserta mengenai penanggulangan bencana alam.
METHOD OF EVALUATION OF TRANSFER NUMBERS IN ION-EXCHANGE MATERIALS
Authors: Koshel Mykola , Koshel Sergiy , Korpach Svitlana 
Published: October 2022

A new method of differential itn-metry has been developed for accurate determination of ion transfer numbers in materials with ion-exchange properties. Such materials include ion exchange membranes, liquid phase ion exchangers and ionic liquids, industrial ion exchange resins. The method is intended as an alternative simplified assessment of the functional properties of ion-exchange resins used in industrial technologies of water purification, water treatment, and extraction at enterprises of various industries. Such accurate information is obtained in special laboratories at enterprises by long-term and expensive physical and chemical methods. Transfer numbers give an indirect assessment of the quality of ion exchangers, but the method of differential itn-metry gives a result in a short 30-minute experiment on the electrolysis of a NaOH or NaCl solution in a three-chamber electrolyzer reactor. The electrolyzer-reactor contains an electrolyte volume of up to 40 cm3. The middle chamber of the electrolyzer-reactor has a variable width from 0.05 to 0.2 cm and an area of 10 cm2 perpendicular to the direction of the electric current.
The primary result of each experiment was the functions of the electrolyte concentration dynamics C(τ) in the extreme cathode and anode chambers of the electrolyzer- reactor, where the dynamics of the readings of the flow resistometric sensor developed by us were recorded during the electrolysis process. The effective transfer number itn* was determined by mathematical data processing using a system of approximation functions.
The method of differential itn-metry will be effective for other resins with amphoteric properties. The use of such a method could be used in works for the study of a wide range of problems in environmental monitoring and management of environmental projects.
Associations between body mass index and pubertal development based on the outcomes of girls with early breast development
Authors: Zhao Manman , Liu Meijuan , Cao Bingyan , Gong Chunxiu 
Published: October 2022

ObjectiveTo investigate the associations between physical and pubertal development based on the breast development outcomes in girls.MethodsThis was a retrospective study. A total of 452 girls aged 6~8 years were included. Based on their breast development outcomes, the patients were divided into an idiopathic central precocious puberty (ICPP) group and a premature thelarche (PT) group. Anthropometry included measurements of height, weight, and BMI. ICPP was diagnosed when five diagnostic criteria from the current guidelines were met.ResultsThe girls with breast development at initial evaluation had a median age of 6.9 years. In total, 31.4% of patients were diagnosed with ICPP, and ICPP was rare in girls &lt;7 years old (19%). Patients who presented with recurrence of breast development in the PT group accounted for 38.4%. At initial evaluation, the height, weight, BMI and bone age (BA) of the girls in the PT group corresponded to those of a normally developing girl at ages 7.8 years, 8.2 years, 8.6 years and 7.6 years, respectively. The girls in the ICPP group had a mean age of 7.3 years, and their mean height, weight, and BMI were 129.6 cm, 28.4 kg, and 17.0 kg/m2, which corresponded to the mean of a normally developing girl at ages 8.5 years, 9.1 years, and 10.5 years, respectively; these patients had BA of 9.2 years. Additionally, based on receiver operating characteristic (ROC) curve analysis, when the basal luteinizing hormone (LH) level was 0.32 IU/L and BMI reached 16.4 kg/m2, CPP was diagnosed in patients meeting all five diagnostic criteria for CPP, and the specificity and sensitivity were 71.9% and 88.2%, respectively.ConclusionsGirls with breast development before 8 years old had a high proportion of recurrence of breast development. The physical development of these girls at the time of breast development preceded that of normally developing girls by 1-2 years. BMI is an independent risk factor for early pubertal development, and is a simple and clear predictor of ICPP. In addition to the five classic diagnostic criteria, CPP is diagnosed when physical development corresponds to the mean for a 10.5 years old girl.
Climate-driven scrub typhus incidence dynamics in South China: A time-series study
Authors: Li Wen , Niu Yanlin , Ren Hongyan , Sun Wanwan , Ma Wei , Liu Xiaobo , Li Guichang , Wang Jun , Liu Qiyong , Lu Liang 
Published: October 2022

Background: Scrub typhus (ST) is a climate-sensitive infectious disease. However, the nonlinear relationship between important meteorological factors and ST incidence is not clear. The present study identified the quantitative relationship between ST incidence and meteorological factors in southern China.Methods: The weekly number of ST cases and simultaneous meteorological variables in central Guangdong Province from 2006 to 2018 were obtained from the National Notifiable Infectious Disease Reporting Information System and the Meteorological Data Sharing Service System, respectively. A quasi-Poisson generalized additive model combined with a distributed lag nonlinear model (DLNM) was constructed to analyze the lag-exposure-response relationship between meteorological factors and the incidence of ST.Results: A total of 18,415 ST cases were reported in the study area. The estimated effects of meteorological factors on ST incidence were nonlinear and exhibited obvious lag characteristics. A J-shaped nonlinear association was identified between weekly mean temperature and ST incidence. A reversed U-shaped nonlinear association was noted between weekly mean relative humidity and ST incidence. The risk of ST incidence increased when the temperature ranged from 24°C to 28°C, the relative humidity was between 78% and 82%, or the precipitation was between 50 mm and 150 mm, using the medians as references. For high temperatures (75th percentile of temperature), the highest relative risk (RR) was 1.18 (95% CI: 1.10–1.27), with a lag effect that lasted 5 weeks. High relative humidity (75th percentile of relative humidity) and high precipitation (75th percentile of precipitation) could also increase the risk of ST.Conclusion: This study demonstrated the nonlinear relationship and the significant positive lag effects of temperature, relative humidity, and precipitation on the incidence of ST. Between particular thresholds, temperature, humidity, and levels of precipitation increased the risk of ST. These findings suggest that relevant government departments should address climate change and develop a meteorological conditions-depend strategy for ST prevention and control.
The integrated landscape of fatty acid metabolism subtypes reveals with prognostic and therapeutic relevance in pancreatic cancer
Authors: Dai Peng , Feng Jing , Dong Yanyan , Zhang Shujing , Cui Xiaopeng , Qin Xueliang , Yang Shiming , Fan Daguang 
Published: October 2022

BackgroundPancreatic Cancer (PAAD) is one of the most commonly diagnosed malignancies and the leading cause of cancer-related death worldwide. Aberrantly expressed long noncoding RNAs (lncRNAs) are involved in tumourigenesis of PAAD, and associated with the overall survival and tumor fatty acid metabolism in PAAD patients.MethodsThe data on gene expression and corresponding clinical characteristics of PAAD patients in TCGA-PAAD (N=177) and GSE62452 (N=65) are taken from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Consensus cluster analysis to identify distinct fatty acid metabolism subtypes in PAAD based on 62 fatty acid metabolism gene. The single sample GSEA (ssGSEA) algorithm was developed for evaluation of tumor infiltrating immune cells between fatty acid metabolism subtypes. As well, the R package “pRRophetic” was used to predict chemotherapeutic response in PAAD patients. Tumor Immune Dysfunction and Exclusion (TIDE) was used to predict immunotherapy response in PAAD patients. Univariate and multivariate Cox analysis were utilized to calculate the prognostic-related lncRNAs.ResultsTotally, three fatty acid metabolism subtypes were obtained in PAAD based on 62 fatty acid metabolism gene. Kaplan-Meier (K-M) analysis showed that the overall survival rate of cluster3 group was significantly higher than the other two groups. Significant differences were seen between the three subtypes in immune cell infiltration characteristics and the immunotherapy response indicators, including Tumor mutational burden (TMB), immunophenoscore (IPS), and immune checkpoint molecules. The cluster1 group and cluster3 group were speculated to have the higher response to immunotherapy patients in cluster2 gains more benefit from chemotherapy than other groups. A 4-lncRNA signature was constructed based on the value of gene expression and regression coefficients which stratified patients into two risk groups. Patients in the higher-risk group had lower survival probabilities than those in the lower-risk group, based on the Kaplan-Meier analysis and Cox regression analysis. Receiver operating characteristic (ROC) curve analysis confirmed the predictive capability. In GO and KEGG analysis, genes in the high-risk group were linked to PAAD development.ConclusionsWe constructed a signature that could predict prognosis of PAAD and provide certain theory guidance for novel therapeutic approaches of PAAD.
Prediction and prevention of preeclampsia by physicians in Brazil: An original study
Authors: Cunha Filho Edson Vieira da , Rodrigues Tamara Cristina Gomes Ferraz , Sandrim Valeria Cristina , Veiga Eduardo Carvalho de Arruda , Cavalli Ricardo Carvalho 
Published: October 2022

BackgroundConsidering the worldwide importance of preeclampsia, especially in Brazil, the screening of pregnant women at greater risk of developing the disease and the application of preventive measures are essential. This study aimed to assess the medical performance in this context in Brazil.MethodsA survey was developed to quantify the number of physicians who prescribe acetylsalicylic acid (ASA) and/or calcium for preeclampsia prevention. The survey was sent to all Brazilian obstetricians affiliated to the Brazilian Federation of OBGYN by email and WhatsApp. The survey remained opened for 6 months and included questions about the use of ASA and calcium, as well as about the use of a complementary test to predict preeclampsia.ResultsThe sample consisted of 360 responding physicians and 100% coverage of responses from physicians from the five different regions of Brazil was obtained. The vast majority of respondents (94.72%) prescribe ASA to prevent preeclampsia, with 80.3% prescribing a dose of 100 mg/day. Calcium is prescribed by 83.9% of the respondents. The majority of the interviewed sample (58.6%) requests uterine artery Doppler imaging to predict preeclampsia and 31.7% do not request any additional test. When the analysis was performed by region, only the northern region differed from the other Brazilian regions regarding the use of ASA and calcium for preeclampsia prevention. While more than 90% of physicians in the other regions prescribe ASA, 40% in the northern region do not use it (p &lt; 0.0001). Regarding calcium, 30% of physicians in northern Brazil do not use the drug for preeclampsia prevention, a percentage that also differs from the other regions where the medication is prescribed by 80 to 90% of physicians (p = 0.021).ConclusionsThe vast majority of Brazilian physicians prescribe low-dose aspirin and calcium carbonate to prevent preeclampsia in high-risk pregnant women. In addition to the identification of clinical risk factors, most doctors use Doppler of the uterine arteries as a predictive method. In the northern region of Brazil, physicians use aspirin and calcium less frequently for preventing preeclampsia compared to the rest of the country.
Risk of COVID-19 infection, hospitalization and mortality in psoriasis patients treated with interleukin-17 inhibitors: A systematic review and meta-analysis
Authors: Liu Meitong , Wang Huijuan , Liu Lu , Cui Saijin , Huo Xiangran , Xiao Zhuoyun , Zhao Yaning , Wang Bin , Zhang Guoqiang , Wang Na 
Published: October 2022

BackgroundCoronavirus disease 2019 (COVID-19) have brought great disaster to mankind, and there is currently no globally recognized specific drug or treatment. Severe COVID-19 may trigger a cytokine storm, manifested by increased levels of cytokines including interleukin-17 (IL-17), so a new strategy to treat COVID-19 may be to use existing IL-17 inhibitors, which have demonstrated efficacy, safety and tolerability in the treatment of psoriasis. However, the use of IL-17 inhibitors in patients with psoriasis during the COVID-19 pandemic remains controversial due to reports that IL-17 inhibitors may increase the risk of respiratory tract infections.ObjectivesThe systematic review and meta-analysis aimed to evaluate the effect of IL-17 inhibitors on the risk of COVID-19 infection, hospitalization, and mortality in patients with psoriasis.MethodsDatabases (including Embase, PubMed, SCI-Web of Science, Scopus, CNKI, and the Cochrane Library) were searched up to August 23, 2022, for studies exploring differences in COVID-19 outcomes between psoriasis patients using IL-17 inhibitors and those using non-biologics. Two authors independently extracted data and assessed the risk of bias in a double-blind manner. The risk ratios (RRs) and 95% confidence intervals (CIs) were calculated and heterogeneities were determined by the Q test and I2 statistic. And the numbers needed to treat (NNTs) were calculated to assess the clinical value of IL-17 inhibitors in preventing SARS-CoV-2 infection and treating COVID-19.ResultsNine observational studies involving 7,106 participants were included. The pooled effect showed no significant differences in the rates of SARS-CoV-2 infection (P = 0.94; I2 = 19.5%), COVID-19 hospitalization (P = 0.64; I2 = 0.0%), and COVID-19 mortality (P = 0.32; I2 = 0.0%) in psoriasis patients using IL-17 inhibitors compared with using non-biologics. Subgroup analyses grouped by age and COVID-19 cases, respectively, revealed consistent results as above. Meanwhile, the pooled NNTs showed no significant differences between the two groups in the clinical value of preventing SARS-CoV-2 infection and treating COVID-19.ConclusionThe use of IL-17 inhibitors in patients with psoriasis does not increase the risk of SARS-CoV-2 infection or worsen the course of COVID-19.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022335195.
Clinical characteristics of combined rosacea and migraine
Authors: Wienholtz Nita K. F. , Christensen Casper E. , Zhang Ditte G. , Rechnagel Anne-Sofie A. , Byrnel Helene V. S. , Haugaard Jeanette H. , Ashina Messoud , Thyssen Jacob P. , Egeberg Alexander 
Published: October 2022

BackgroundAn overlap between the skin disease rosacea and the headache disease migraine has been established; however, the magnitude of this overlap and the distribution between subtypes/phenotypes remains unclear.ObjectiveThe aim was to determine the magnitude of the overlap between rosacea and migraine, and to determine which subtypes/phenotypes were present in patients with concomitant rosacea and migraine.MethodsIn this cross-sectional study, 604 patients with a diagnosis of either rosacea or migraine were phenotyped through a face-to-face interview with clinical examination, to determine prevalence and phenotype of rosacea, and prevalence and subtype of migraine.ResultsWe found a prevalence of migraine of 54% in patients with rosacea, and a prevalence of rosacea of 65% in patients with migraine. Concomitant migraine was significantly associated with the rosacea features flushing (odds ratio = 2.6, 95% confidence interval = 1.4–4.7, p = 0.002), ocular symptoms (odds ratio = 2.4, 95% confidence interval = 1.5–3.9, p &lt; 0.001), and burning (odds ratio = 2.1, 95% confidence interval = 1.3–3.4, p = 0.002), whereas papules/pustules were inversely related with concomitant migraine (odds ratio = 0.5, 95% confidence interval = 0.3–0.8, p = 0.006). No association was found between concomitant migraine and centrofacial erythema, rhinophyma, telangiectasia, edema, or dryness. Concomitant rosacea was not associated with any specific migraine subtype in patients with migraine.ConclusionThis study highlights a substantial overlap between rosacea and migraine, particularly in patients with certain rosacea features. Individuals with rosacea should be asked about concomitant migraine, and comorbidities should be considered when choosing between treatments.
Association of metastatic nodal size with survival in non-surgical non-small cell lung cancer patients: Recommendations for clinical N staging
Authors: Zhang Yanan , Liu Zhehui , Wang Hongmin , Liang Fengfan , Zhu Liqiong , Liu Haifeng 
Published: October 2022

BackgroundThis study aims to analyze the prognostic significance of the metastatic lymph node (mLN) size in non-small cell lung cancer (NSCLC) patients receiving chemoradiotherapy (CRT) to provide some information for the optimization of clinical nodal (cN) staging.MethodsA retrospective study with 325 NSCLC patients was conducted between January 2011 and December 2018 at two participating institutes. We evaluated the potential relationship between the mLN size and the survival to propose a potential revised nodal (rN) staging.ResultsKaplan–Meier analyses showed significant differences in the overall survival (OS) based on the cN staging and the size of mLNs (N0, ≤2 cm, and &gt;2 cm). We found that the nodal size correlated statistically with the response to CRT. The HRs of OS for patients with bulky mLNs increase significantly compared with patients in the non-bulky mLNs group in the cN2-3 group. Interestingly, the HRs of patients with bulky cN2 disease and non-bulky cN3 disease were similar to each other. We classified the patients into five subsets: N0, rN1(cN1), rN2(non-bulky cN2), rN3a(bulky cN2, and non-bulky cN3), and rN3b(bulky cN3). In our study, the rN stage showed better prognostic discrimination than the 8th IASLC cN staging and was an independent prognostic factor for survival.ConclusionsIn addition to the anatomic location, the size of mLNs correlated statistically with the response to CRT and should be incorporated into the cN staging system to predict survival more accurately.