bluuebunny/crossref_metadata_2025_split huggingface dataset:
A transient increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in human neural progenitors at early stages of neuronal differentiation.
Authors: Ferretti Gabriella , Romano Alessia , Sirabella Rossana , Serafini Sara , Maier Throsten , Matrone Carmela 
Published: July 2022

Abstract
BackgroundSemaphorins (Sema) belong to a large family of repellent guidance cues instrumental in guiding axons during development. In particular, Class 3 Sema (Sema 3) are among the best characterized Sema family members and are the only produced as secreted proteins in mammals, thereby exerting both autocrine and paracrine functions. Intriguingly, an increasing number of studies supports the crucial role of the Sema 3A in hippocampal and cortical neurodevelopment, meaning that alterations in Sema 3A signaling might compromise hippocampal and cortical circuits and predispose to disorders such as autism and schizophrenia. Consistently, increased Sema 3A levels have been detected in brain of patients with schizophrenia and many polymorphisms in Sema 3A or in the Sema 3A receptors, Neuropilins (Npn 1 and 2) and Plexin As (Plxn As), have been associated to autism. ResultsHere we present data indicating that when overexpressed, Sema 3A causes human neural progenitors (NP) axonal retraction and an aberrant dendritic arborization. Similarly, Sema 3A, when overexpressed in human microglia, triggers proinflammatory processes that are highly detrimental to themselves as well as NP. Indeed, NP incubated in microglia overexpressing Sema 3A media retract axons within an hour and then start suffering and finally die. Sema 3A mediated retraction appears to be related to its binding to Npn 1 and Plxn A2 receptors, thus activating the downstream Fyn tyrosine kinase pathway that promotes CDK5 phosphorylation at the Tyr15 residue and the CDK5 processing to generate the active fragment p35. ConclusionsAll together this study identifies Sema 3A as a critical regulator of human NP differentiation thus implying that an insult due to Sema 3A overexpression during the early phases of neuronal development might compromise neuronal organization and connectivity and make neurons perhaps more vulnerable to other insults across their lifespan.
Indications for resection of recurrent lesions in patients with distal cholangiocarcinoma based on prognostic factors: A single-institute retrospective study and brief literature review
Authors: Mashiko Taro , Ogasawara Toshihito , Masuoka Yoshihito , Ei Shigenori , Takahashi Shinichiro , Mori Masaki , Koyanagi Kazuo , Yamamoto Seiichiro , Nakagohri Toshio 
Published: July 2022

Abstract
Background
To evaluate the effectiveness of surgery for recurrent distal cholangiocarcinoma and determine surgical indications based on prognostic factors of primary and recurrent distal cholangiocarcinoma.
Methods
We analysed the outcomes of 101 patients who underwent surgical resection for distal cholangiocarcinoma during 2000–2018 and investigated the clinicopathological factors and prognosis of primary and recurrent distal cholangiocarcinoma.
Results
Of the 101 patients with resected distal cholangiocarcinoma, 52 (51.5%) had relapsed. Seven (13.5%) and 45 patients (86.5%) underwent resection of recurrent lesions and palliative therapy, respectively. There were no major complications requiring therapeutic intervention after metastasectomy. The median overall survival in patients with and without surgery for recurrent lesions was 83.0 (0.0–185.6) and 34 months (19.0–49.0), respectively. Therefore, patients who had undergone surgery for recurrent lesions had a significantly better prognosis (p = 0.022). Multivariate analyses of primary distal cholangiocarcinoma revealed that positive lymph node metastasis, positive portal vein invasion, and recurrence within one year were independent predictors of poor survival. Multivariate analyses of recurrent distal cholangiocarcinoma revealed that recurrence within one year were independent predictors of poor survival. Resection of recurrent lesions improved prognosis.
Conclusions
Radical resection in recurrent distal cholangiocarcinoma may improve the prognosis in selected patients. In particular, patients with negative lymph node metastases, negative portal vein invasion at the time of the first surgery, and where recurrence is more than a year are considered good candidates for metastasectomy.
Tri-level Framework for Realistic Estimation of Concrete Strength using Bayesian Data Fusion of UPV and Guided Coring
Authors: Faroz Sharvil Alex , Ghosh Siddhartha , Faroz Alex Michael 
Published: July 2022

Abstract
Identification of \textit{in situ} concrete characteristic strength (CCS) of deteriorating RC structures directly affects their rehabilitation. Contemporary practices lack the ability to yield CCS or at most produce an unrealistic estimate, because: (i) core tests are few due to technical and economic constraints and their positioning is random, inducing bias in the strength estimate, (ii) non-destructive tests (NDT) are themselves not good estimators of project specific strength, (iii) tests are only local indicators and most practising engineers are unaware of how to process the spatial variability. This paper overcomes these limitations with a novel and implementable framework, for an asset manager to make scientific estimates of CCS. This is a tri-level framework: (1) NDT are performed to capture the spatial variability of the investigated concrete; (2) core extractions are guided by the prior NDT information, to avoid bias in test location selection; (3) NDT and coring results are fused via Bayesian NDT test calibration and updating of the probability distribution of the concrete strength. The proposed framework is implemented for the assessment and rehabilitation of a critical hospital complex in India.
A novel bi-directional heterogeneous network selection method for disease and microbial association prediction
Authors: Guan Jian , Zhang Zhao Gong 
Published: July 2022

Abstract
Microorganisms in the human body have a great impact on human health. Therefore, mastering the potential relationship between microorganisms and diseases is helpful to understand the pathogenesis of diseases and is of great significance to the prevention, diagnosis and treatment of diseases.In order to predict the potential microbial disease relationship, we propose a new computational model. Firstly, a bi-directional heterogeneous microbial disease network is constructed by integrating multiple similarities, including Gaussian kernel similarity, microbial function similarity, disease semantic similarity and disease symptom similarity. Secondly, the neighbor information of the network is learned by random walk; Finally, the selection model is used for information aggregation, and the microbial disease node pair is analyzed. Our method is superior to the existing methods in leave-one-out cross-validation and five-fold cross-validation. Moreover, in case studies of different diseases, our method is effective.
Nanocellulose/chitosan biohybrid aerogel bead adsorbent for removal of diclofenac sodium from wastewater: preparation, characterization, and adsorption mechanism
Authors: Tang Qi , Qiu Chongpeng , Zhang You , Zhang Xuefeng , Yuan Zihui , Tan Hailu , Wang Lei , Hoop Cornelis F. , Qi Jinqiu , Huang Xingyan 
Published: July 2022

Abstract
In this work, a novel nanocellulose/chitosan biohybrid aerogel (NCBA) bead adsorbent was successfully prepared from oxidized bamboo nanocellulose and chitosan to remove diclofenac sodium (DS) from wastewater. Fourier transform infrared spectroscopy, scanning electron microscopy, and X-ray photoelectron spectroscopy were used to characterize the preparation of NCBA bead adsorbent. The results demonstrated that the adsorption kinetics were well described by the pseudo-second-order model, and the adsorption isotherms were well fitted by the Sips isotherm model with the maximum adsorption capacity of 321.26 mg/g on DS, which is much higher than most of the previously reported works. The absorption mechanism was governed by electrostatic interaction and hydrogen bond interaction. Moreover, the resulting bead remained a high removal efficiency after 5 regeneration cycles. In summary, it had been proved that the aerogel bead was an efficient bio-sorbent for removing DS from aqueous solutions.
Sounds with high-frequency components above the human audible range improve glucose tolerance: A quasi-experimental crossover study
Authors: Kawai Norie , Honda Manabu , Nishina Emi , Ueno Osamu , Fukushima Ariko , Ohmura Rikka , Fujita Nahiko , Oohashi Tsutomu 
Published: July 2022

Abstract
Although stress has a significant impact on various metabolic syndrome, including diabetes mellitus, most stress management techniques are psychological and subjective approaches. We previously reported that sounds rich in inaudible high-frequency component (HFC) activate deep-brain structures such as midbrain, thalamus and hypothalamus, which are closely related to stress reactions. The present study examined how the presence or absence of the inaudible HFC of sounds affects glucose tolerance in healthy subjects using oral glucose tolerance test (OGTT). Sounds containing HFC suppressed the increase in blood glucose levels in the OGTT compared with the otherwise same sounds without HFC. The suppression effect of HFC was more prominent in the older age group and the group with high HbA1c. This suggests that sounds with HFC are more effective in improving glucose tolerance in individuals who have potentially impaired glucose tolerance. This study provides a proof of concept for future investigation that sounds rich in HFC may be an effective nonpharmacological alternative for people with abnormal glucose tolerance function.
Whole genome sequence of mulberry crinivirus (MuCV), an uncommon crinivirus containing a tRNA-like structure at the 5'- and 3'-ends of RNA1
Authors: Lu Quan-You , Zhang Peng , Han Tao-Tao , Tang Jia-Xuan , Zhong Kui , Ma Yu , Smith William-Kojo , Zhao Wei-Guo 
Published: July 2022

Abstract
The whole genome sequence of mulberry crinivirus (MuCV), a novel member of the genus Crinivirus (family Closteroviridae) identified from mulberry (Morus alba L), was determined. The bipartite genome of MuCV consists of RNA1, which contains 8571 nucleotides (nt) with four putative open reading frames (ORFs), and RNA2, which contains 8082 nt with eight putative ORFs. The most striking features exhibited by MuCV are tRNA-like structures at the 5'- and 3' -ends of RNA1, which have not been reported for all known members of the family Closteroviridae. Phylogenetic analysis based on RdRp amino acid sequences of criniviruses placed MuCV in “Group 1”.
The Improved X-ray Detector (iXRD) on Sharjah-Sat-1, design principles, tests and ground calibration
Authors: Kalemci Emrah , Altingun Ali M. , Bozkurt Ayhan , Aslan Alim Rustem , Yalcin Refik , Gokalp Kaya , Veziroglu Kaan , Fernini Ilias , Manousakis Antonios , Yasar Ali , Diba Milad , Karabulut Bogac , Catal Egemen , Oztekin Onur 
Published: July 2022

Abstract
The ixRD is the primary science payload on Sharjah-Sat-1, a 3U CubeSat expected to be launched in Q4, 2022. Its main scientific goal is monitoring bright hard X-ray sources and transients in 20 - 200 keV band. The iXRD consists of a CdZnTe crystal (6.45 cm2 area, 5 mm thickness), a Tungsten collimator with square holes with an opening angle of 4.26o, readout and control electronics and power circuitry, a back-shield and mechanical structures.
Some of the design elements of iXRD have been inherited from the XRD on BeEagleSat with significant improvements in terms of collecting area, X-ray background and electronic noise. In this article, the design of the iXRD is discussed in detail taking into account mechanical, electronics, control software and data handling aspects. Its expected performance is determined after ground calibration. Depending on the pixel size, the energy resolution is 4 - 7 keV at 60 keV and the minimum detectable energy is 19 - 23 keV.
A composite blockchain associated event traceability method for financial activities
Authors: Wang Junlu , Li Su , Ji Wanting , Li Dong , Song Baoyan 
Published: July 2022

Abstract
The existing blockchain system mostly adopts the equal mining mode. All bookkeepers (entities) record the ledger books on a single master chain. The data storage is random. Moreover, in complex or classified financial scenarios, master chain data is difficult to be correlated or stored regularly, resulting in low efficiency of storage and query; At the same time, in the existing blockchain system, event traceability is mostly only found in the source block, and the implicit association between entities cannot be identified. To solve these problems, this paper proposes a composite blockchain associated event traceability method. This method firstly constructs the blockchain composite chain storage structure model, proposes the concept of private chain and alliance chain, and realizes the adaptive data association storage in complex or classified scenarios. Secondly, on the basis of obtaining the entity block of event source, auxiliary storage space is established to transfer storage relevant data. A query method of associated entity block based on Apriori algorithm is proposed, and the obtained traceability entity block is constructed to construct the source event association diagram, so as to describe the association relationship between event entities. Finally, a risk assessment system based on reinforcement learning is proposed to realize the risk assessment of traceability entity. Experiments show that the composite blockchain associated event traceability method proposed in this paper can reduce 60% of the storage overhead, improve 90% of the query accuracy and 50% of the security.
Fitness, body composition and metabolic syndrome score in children and adolescents: The UP&amp;DOWN study
Authors: Sánchez-Delgado Alejandro , Pérez-Bey Alejandro , Izquierdo-Gómez Rocío , Jiménez-Iglesias José , Marcos Ascensión , Gómez-Martínez Sonia , Girela-Rejón María José , Veiga Oscar L , Castro-Piñero José 
Published: July 2022

Abstract
Purpose: We aimed to analyse the longitudinal association between physical fitness (PF) and body composition (BC) with metabolic syndrome score (MetS) in children and adolescents, and to elucidate whether the association between PF and MetS differs when using relativized or absolute fitness variables. Methods: A total of 188 children (86 females) and 195 adolescents (97 females) were included. Cardiorespiratory fitness (CRF) was determined by the 20-m shuttle run test and muscular fitness (MF) was determined by hand grip and standing long jump tests. Height and weight were measured, and body mass index (kg/m2) was calculated. Triceps and subscapular skinfolds were assessed to compute body fat percentage. MetS was computed from: waist circumference, systolic blood pressure, triglycerides, high-density lipoprotein cholesterol and glucose levels.Results: Relative CRF was longitudinally and negatively associated with MetS in female children (β=-0.031,p=0.025), while absolute CRF was positively associated with MetS in male children and adolescents (β=0.000,p<0.05). Relative upper and lower-body MF were longitudinally and negatively associated with MetS in female adolescents (β=-1.347,β=-0.005,p<0.05), while absolute lower-body MF was positively associated with MetS in male children (β=0.000,p=0.019). BC was longitudinally and positive associated with MetS in male children (β-ranging from 0.011-0.055,all p<0.05) and male adolescents (β-ranging from 0.011-0.046,all p<0.05).Conclusion: BC is more strongly associated with MetS than PF in children and adolescents. An optimal body weight status should be considered the main objective of health promoting programs at childhood and adolescence. Furthermore, the way of expressing the fitness variables determines the direction of the association with MetS.
P-metric: a multi-factor publication metric
Authors: Datta Dilip 
Published: July 2022

Abstract
Currently the h-index is a widely used metric for measuring the impacts of publications of individual authors. However, many limitations of this metric have been reported over the years since its introduction. Other proposals have also been made to overcome such limitations, but none could get a better acceptance. A new metric, namely $P$-metric, is proposed here by incorporating multiple factors, including the author-wise amount of contribution, citation count, quality of each publication, and quality of each journal from which citations are received. The P-metric will not only overcome many limitations of the existing metrics by rewarding authors separately for every individual publication and its citation count, but it is also likely to reduce drastically the number of gift and guest authors. Moreover, the P-metric with a little modification can be used to measure the impacts of journals also.
Treatment, outcome and re-vaccination of patients with SARS-CoV-2 vaccine-associated immune thrombocytopenia
Authors: Ruzicka Michael , Wurm Sonja , Lindner Lars , Dreyling Martin , von Bergwelt-Baildon Michael , Boeck Stefan , Giessen-Jung Clemens , Milani Valeria , Stemmler Hans Joachim , Subklewe Marion , Weigert Oliver , Spiekermann Karsten 
Published: July 2022

Abstract
Purpose:Following the emergency use authorization of BNT162b2 by the Food and Drug administration (FDA) in early December 2020, mRNA- and vector-based vaccines became an important means of reducing the spread and mortality of the COVID-19 pandemic. The European Medicines Agency labelled immune thrombocytopenia (ITP) as a rare adverse reaction of unknown frequency after vector-, but not mRNA-vaccination. Here, we report on the long-term outcome of 6 patients who were diagnosed with de-novo, vaccine-associated ITP (VA-ITP), and on the outcome of subsequent SARS-CoV-2 re-vaccinations.Methods: Patients were included after presenting to our emergency department. Therapy was applied according to ITP guidelines. Follow-up data were obtained from outpatient departments. Both mRNA- or vector-based vaccines were each used in 3 cases, respectively.Results:In all patients, the onset of symptoms occurred after the 1st dose of vaccine was applied. 5 patients required treatment, 3 of them 2nd line therapy. All patients showed a complete response eventually. After up to 359 days of follow-up, 2 patients were still under 2nd line therapy with thrombopoietin receptor agonists. 5 patients have been re‑vaccinated with up to 3 consecutive doses of SARS-CoV-2 vaccines, 4 of them showing stable platelet counts hereafter. Conclusion:Thrombocytopenia after COVID-19 vaccination should trigger a diagnostic workup to exclude vaccine-induced immune thrombotic thrombocytopenia (VITT) and, if confirmed, VA-ITP should be treated according to current ITP guidelines. Re-vaccination of patients seems feasible under close monitoring of blood counts and using a vaccine that differs from the one triggering the initial episode of VA-ITP.
Evaluation of F1 Hybrid Tomato Cultivars for Earliness, Fruit Size, and Yield Using Diallel Analysis1
Authors: Gibrel Gomaa , Boe A. A. , Simpson W. R. , Everson D. O. 
Published: July 2022

Abstract
Twelve cultivars and one breeding line of tomatoes, (Lycopersicon esculentum Mill.) which varied in maturity from early to late cultivars, were crossed in a diallel to estimate general and specific combining ability for earliness, fruit size, and yield using Griffing's method II, model II. General combining ability mean squares for earliness at 3 stages expressed as growing degree days (GDD) (10–32°C); and for number of days were larger than specific combining ability mean squares except for the index of first flowering stage to first fruit set. Days from seeding to first flowering and of first fruit set to first ripe fruit were positively correlated with each other and with total earliness. However, days from first flowering to first fruit set was not correlated either with the period from first fruit set to first ripe fruit or with total earliness. Fruit sizes, measured at the 3 different times were positively correlated with each other and with overall average size. A positive correlation resulted between the September 1st and October 1st yields and total yield. There was no significant correlation between fruit size and yield. General and specific combining ability mean squares were estimated on August 1st, September 1st, and October 1st for fruit size and yield. Broad sense heritability estimates were high and narrow sense heritability estimates were low, for both fruit size and yield.
Effects of Mechanical and Hand Pruning, Tree Spacing, and Limb Bending on Tree Development and Yield of Hedgerow ‘Delicious’ Apples on Mailing Merton 106 Rootstock1
Authors: Dozier W. A. , Carlton C. C. , Short K. C. 
Published: July 2022

Abstract
A combination of mechanical and hand pruning each year from 1971-1976 reduced pruning time over that of hand pruning alone for ‘Delicious’ apple (Malus domestica Borkh.). Yield was not significantly affected by pruning method with one exception in 1975. The use of the mechanical pruner destroyed the framework of the tree by inducing a thick canopy and reducing light penetration. Yield was increased by limb positioning at both the 2.3- and 3.0-m spacings. In 1974, higher yields were obtained with the 1.5-m spaced trees and in 1979 with the 3.0-m spaced trees. Average fruit weight was less for the 1.5-m spaced trees than for the 3.0-m spaced trees.
Impact of Wheat Cultivars on Establishment and Suppression of Summer Annual Weeds1
Authors: Wicks G. A. , Ramsel R. E. , Nordquist P. T. , Schmidt J. W. , Challaiah  
Published: July 2022

AbstractDifferences in weed interference among winter wheat (Triticum aestivumL.) cultivars have been observed in farmer fields. Identifying cultivars that are more competitive would be useful in weed control programs. Twenty cultivars of winter wheat were grown with spring germinating weeds during 1979 and 1980 and eight cultivars were grown in 1981 at North Platte, NE on a Typic Argiustoll soil. Cultivars included semi‐dwarf through normal statured types and were adapted to a wide geographic area of the Central Great Plains. ‘Lancota’ selections (NE 78939, NE 78906, NE 78895, NE 78892, and NE 78925) and sister lines NE 78742 and NE 78743 were good weed competitors. ‘Centurk 78’, ‘Buckskin’, ‘Vona’, and ‘Sage’ were intermediate, while ‘Homestead’ and several lines with Homestead germplasm were relatively poor annual weed competitors. Several cultivars that were 73 to 78 cm tall were poor competitors with weeds, while most cultivars that were 83 cm or taller were good competitors. NE 78742 (75 cm) and NE 78743 (72 cm) were among the shortest cultivars but were among the best in competitiveness with weeds. Cultivar selection can reduce summer annual weed growth in winter wheat