bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-powered broadband photodetector based on MoS2/Sb2Te3 heterojunctions: a promising approach for highly sensitive detection
Authors: Wang Hao , Gui Yaliang , Dong Chaobo , Altaleb Salem , Nouri Behrouz Movahhed , Thomaschewski Martin , Dalir Hamed , Sorger Volker J. 
Published: October 2022

Abstract
Topological insulators have shown great potential for future optoelectronic technology due to their extraordinary optical and electrical properties. Photodetectors, as one of the most widely used optoelectronic devices, are crucial for sensing, imaging, communication, and optical computing systems to convert optical signals to electrical signals. Here we experimentally show a novel combination of topological insulators (TIs) and transition metal chalcogenides (TMDs) based self-powered photodetectors with ultra-low dark current and high sensitivity. The photodetector formed by a MoS2/Sb2Te3 heterogeneous junction exhibits a low dark current of 2.4 pA at zero bias and 1.2 nA at 1V. It shows a high photoresponsivity of >150 mA W−1 at zero bias and rectification of 3 times at an externally applied bias voltage of 1V. The excellent performance of the proposed photodetector with its innovative material combination of TMDs and TIs paves the way for the development of novel high-performance optoelectronic devices. The TIs/TMDs transfer used to form the heterojunction is simple to incorporate into on-chip waveguide systems, enabling future applications on highly integrated photonic circuits.
Dysfunctional microglia and tau pathology in Alzheimer’s disease
Authors: Ayyubova Gunel 
Published: October 2022

Abstract
Extensive human studies and animal models show that chronic immune system stimulation involving microglia, inflammasome, complement activation, synthesis of cytokines, and reactive oxygen species exacerbates neurodegeneration in Alzheimer’s disease (AD) and other tauopathies. Abnormalities in tau, Aβ, and microglial activation are frequently observed in dementia patients and indicate that these elements may work in concert to cause cognitive impairment. Contradicting reports from postmortem studies demonstrating the presence of Aβ aggregates in the brains of cognitively healthy individuals, as well as other investigations, show that tau aggregation is more strongly associated with synapse loss, neurodegeneration, and cognitive decline than amyloid pathology. Tau association with microtubules’ surface promotes their growth and maintains their assembly, dynamicity, and stability. In contrast, the reduced affinity of hyperphosphorylated and mislocalized tau to microtubules leads to axonal deficits and neurofibrillary tangles (NFTs). Loss of microglial neuroprotective and phagocytic functions, as indicated by the faulty clearance of amyloid plaques, as well as correlations between microglial activation and tau tangle spread, all demonstrate the critical involvement of malfunctioning microglia in driving tau propagation. This review discusses the recent reports on the contribution of microglial cells to the development and progression of tau pathology. The detailed study of pathogenic mechanisms involved in interactions between neuroinflammation and tau spread is critical in identifying the targets for efficacious treatment strategies in AD.
Allocation of Visuospatial Attention Indexes Evidence Accumulation for Reach Decisions
Authors: Schonard Carolin , Heed Tobias , Seegelke Christian 
Published: October 2022

AbstractVisuospatial attention is a prerequisite for the performance of visually guided movements: perceptual discrimination is regularly enhanced at target locations before movement initiation. It is known that this attentional prioritization evolves over the time of movement preparation; however, it is not clear whether this build-up simply reflects a time requirement of attention formation or whether, instead, attention build-up reflects the emergence of the movement decision. To address this question, we combined behavioral experiments, psychophysics, and computational decision-making models to characterize the time course of attention build-up during motor preparation. Participants (n = 46, 29 female) executed center-out reaches to one of two potential target locations and reported the identity of a visual discrimination target (DT) that occurred concurrently at one of various time-points during movement preparation and execution. Visual discrimination increased simultaneously at the two potential target locations but was modulated by the experiment-wide probability that a given location would become the final goal. Attention increased further for the location that was then designated as the final goal location, with a time course closely related to movement initiation. A sequential sampling model of decision-making faithfully predicted key temporal characteristics of attentional allocation. Together, these findings provide evidence that visuospatial attentional prioritization during motor preparation does not simply reflect that a spatial location has been selected as movement goal, but rather indexes the time-extended, cumulative decision that leads to the selection, hence constituting a link between perceptual and motor aspects of sensorimotor decisions.
Entorhinal–Hippocampal Circuit Integrity Is Related to Mnemonic Discrimination and Amyloid-β Pathology in Older Adults
Authors: Adams Jenna N. , Kim Soyun , Rizvi Batool , Sathishkumar Mithra , Taylor Lisa , Harris Alyssa L. , Mikhail Abanoub , Keator David B. , McMillan Liv , Yassa Michael A. 
Published: October 2022

Mnemonic discrimination, a cognitive process that relies on hippocampal pattern separation, is one of the first memory domains to decline in aging and preclinical Alzheimer's disease. We tested whether functional connectivity (FC) within the entorhinal–hippocampal circuit, measured with high-resolution resting state fMRI, is associated with mnemonic discrimination and amyloid-β (Aβ) pathology in a sample of 64 cognitively normal human older adults (mean age, 71.3 ± 6.4 years; 67% female). FC was measured between entorhinal–hippocampal circuit nodes with known anatomical connectivity, as well as within cortical memory networks. Aβ pathology was measured with18F-florbetapir-PET, and neurodegeneration was assessed with subregional volume from structural MRI. Participants performed both object and spatial versions of a mnemonic discrimination task outside of the scanner and were classified into low-performing and high-performing groups on each task using a median split. Low object mnemonic discrimination performance was specifically associated with increased FC between anterolateral entorhinal cortex (alEC) and dentate gyrus (DG)/CA3, supporting the importance of this connection to object memory. This hyperconnectivity between alEC and DG/CA3 was related to Aβ pathology and decreased entorhinal cortex volume. In contrast, spatial mnemonic discrimination was not associated with altered FC. Aβ was further associated with dysfunction within hippocampal subfields, particularly with decreased FC between CA1 and subiculum as well as reduced volume in these regions. Our findings suggest that Aβ may indirectly lead to memory impairment through entorhinal–hippocampal circuit dysfunction and neurodegeneration and provide a mechanism for increased vulnerability of object mnemonic discrimination.SIGNIFICANCE STATEMENTMnemonic discrimination is a critical episodic memory process that is performed in the dentate gyrus (DG) and CA3 subfield of the hippocampus, relying on input from entorhinal cortex. Mnemonic discrimination is particularly vulnerable to decline in older adults; however, the mechanisms behind this vulnerability are still unknown. We demonstrate that object mnemonic discrimination impairment is related to hyperconnectivity between the anterolateral entorhinal cortex and DG/CA3. This hyperconnectivity was associated with amyloid-β pathology and neurodegeneration in entorhinal cortex, suggesting aberrantly increased network activity is a pathological process. Our findings provide a mechanistic explanation of the vulnerability of object compared to spatial mnemonic discrimination in older adults and has translational implications for choice of outcome measures in clinical trials for Alzheimer's disease.
Job retention opportunities in a pandemic crisis based on the example of three countries in the Asia-Pacific region
Authors: Tóth Arnold , Kálmán Botond Géza , Engle Allen D. , Poór József 
Published: October 2022

AbstractOur study examines the development of unemployment data from three strong Asian economies, China, Korea, and Japan. The focus is on the impact of the economic crisis caused by COVID-19, as well as an overview of the possible solutions to combat the impact of similar future crises on the labour market, in the hope of mitigating future economic dislocations. Following an overview of the region's economy and the pandemic, we use stochastic modelling of unemployment data of ten years prior to the pandemic, to estimate counterfactual future data without the pandemic. We then compare this estimate with real data during the pandemic. We did this in order to explore ideas and new solutions that could possibly be applied in Hungary, which is presently burdened by a very significant labour shortage.
Clinical approach and diagnosing bladder stone in a 74-year-old man patient: a case report
Authors: Nurcahya I G. N. M. , Suryana K. 
Published: October 2022

This article reports a 74-year-old man came to the emergency department with complaint blood in urine, urinary tract symptom such as nocturia, frequency urgency, and cloudy urine. Physical examination showed suprapubic area was hard on palpation. The abdominal X-ray of the patient showed an opaque stone in the bladder. An ultrasound scan showed a multiple bladder stone with the longest stone 1.59 cm in size. Bilateral kidney cyst and the prostate was enlarged with volume ±123.85 cc, IPP 2.29 cm. Entire stone elimination and eradication related BPH and urinary tract infections (UTIs) are the principal goal of the remedy. The patient was treated with Lithotripsy, antibiotics, alpha-blockers, antihypertension medications and showed clinical remission.
Nonsurgical management of class II division 1 malocclusion in an adult patient using fixed functional appliance: A case report
Authors: Rastogi Shikha , Gohilot Avinash , Singh Gurkeerat 
Published: October 2022

This case report highlights the effective and efficient usage of fixed functional appliance in the management of class II div 1 malocclusion with retrognathic mandible and deep overbite in an adult individual. Orthognathic surgery and Orthodontic camouflage with premolar extraction were not considered in the present case. The Mandibular Protraction Appliance (MPA type 2) was considered due to ease of fabrication, placing it simultaneously along with fixed mechanotherapy.
Toxicity of new monophenolic synthetic activator of Keap1/Nrf2/ARE redox-sensitive signaling system <i>in vitro</i> and <i>in vivo</i>
Authors: Khrapova M. V. , Khrapov S. E. , Chechushkov A. V. , Kozhin P. M. , Romakh L. P. , Serykh A. E. , Kholshin S. V. , Kandalintseva N. V. , Menshchikova E. B. 
Published: October 2022

One of the promising areas of modern pharmacology is the development of «indirect antioxidants» capable of activating redox-sensitive signaling systems, primarily the Keap1/Nrf2/ARE system. Among its chemical inductors is the hydrophilic monosubstituted monophenol (3’-tert-butyl-4’-hydroxyphenyl)sodium propylthiosulfonate (TS-13) in development. The aim of the study was to investigate TS-13 antiproliferative activity against tumor cell line BT-474 in vitro and acute oral toxicity in mice in vivo. Material and methods. The relationship between TS-13 concentration and proliferative activity of human breast ductal carcinoma cell line BT-474 was determined using the MTT test, the IC<sub>50</sub> was calculated and compared to the previously obtained for MCF-7 line; results were correlated with the functional properties of cells based on gene expression (in silico GSEA). In vivo acute toxicity was studied in 50 female C57Bl/6J mice, who received a TS-13 solution in distilled water at various doses by intragastric gavage. LD<sub>50</sub> obtained experimentally and predicted in silico using the GUSAR web service were compared. Results and discussion. TS-13 inhibited the proliferation of BT-474 cells in a concentration-dependent manner (exponential approximation, IC<sub>50</sub> = 59.5 μM) and was 2.2 times more toxic than for MCF-7 cells. This may be due to functional differences between the BT-474 and MCF-7 lines, as evidenced by the GSEA results. The LD<sub>50</sub> value established in the in vivo experiment was 936 mg/kg body weight, the obtained value satisfactorily corresponds to the predicted in silico (561 mg/kg), although in reality the compound turned out to be somewhat less toxic than could be expected based on its structure. Conclusions. A study of the acute toxicity of the new water-soluble monophenol TC-13 allows the classification of it as slightly toxic (toxicity rating level 4) according to the Hodge – Sterner scale) or as moderately hazardous (hazard class 3) according to GOST 12.1.007-76.
The effect of silver-containing sorbent on red blood cells during hemosorption: an <i>in vitro</i> study
Authors: Rachkovskaya L. N. , Smagin A. A. , Nimaev V. V. , Demura A. Yu. , Rachkovsky E. E. , Yastrebova E. S. , Maltsev V. P. , Korolev M. A. , Letyagin A. Yu. 
Published: October 2022

The aim of the study was to investigate the influence of the original porous silver–containing sorbent on the morphofunctional parameters of red blood cells during in vitro hemoperfusion. Material and methods. Donor blood was perfused through glass columns filled with a sorbent based on porous aluminum oxide, polydimethylsiloxane and silver nanoclusters and a sorbent without silver. The effect of a silver-containing sorbent on the change in morphofunctional parameters of red blood cells after perfusion through sorbents was determined by scanning flow cytometry. Results and their discussion. Due to the uniformity of the distribution of silver (0.1 %) over the sorbent granules, the parameters of the porous structure – the specific surface area and pore volume – practically do not change compared to the sorbent without silver. Morphological parameters of original donor blood and after hemoperfusion are within the norm. The functional parameters are also normal, although the introduction of silver in to the sorbent slightly increases the number of active band 3 (B3) proteins on erythrocyte membranes, both in comparison with the donor red cell mass as a control and in comparison with the sorbent without silver. There is also an increase in the ultimate extensibility of the erythrocyte membrane compared to the original blood (2.2 times) and the sorbent without silver (1.4 times). Conclusions. A sorbent modified with silver and a sorbent without silver does not have a damaging toxic effect on the morphofunctional parameters of blood under perfusion conditions. The mechanisms affecting the indicators of the ultimate extensibility of the erythrocyte membrane after blood perfusion through a silver-containing sorbent require further research.
Evaluation of deadspace effects created by heat and moisture exchange filter during artificial lung ventilation in newborns
Authors: Shmakov A. N. , Budarova K. V. , Elizar’eva N. L. , Kokhno V. N. 
Published: October 2022

Heat and moisture exchange filters create additional dead space, comparable in volume to physiological, in premature newborns. It makes carbon dioxide remove difficultу. Reducing the dead space volume by increasing the flow in the ventilator circuit can lead to the hypocapnia. Aim of the study was to determine the safety and efficiency of gas flow boost in the ventilator circuit to hypercapnia compensation created by the additional dead space. Material and methods. The effect of the additional dead space created by a heat and moisture exchange filter on hemoglobin saturation and partial pressure of carbon dioxide at the end of expiration in premature newborns at flows of 5 and 6 l/min was studied. Results and discussion. It has been demonstrated that flows of 5–6 l/min satisfactorily compensate for the effect of additional deadspace without hypocapnia. Conclusions. It is possible to recommend the widespread use of heat and moisture exchange filters in newborn weighing at least 1.0 kg during long-term transportation.
Identification of existing tools and workflows for solar neighborhood planning
Authors: Baker Nicholas , Belmonte Monteiro Rafaella , Boccalatte Alessia , Bouty Karine , Brozovsky Johannes , Caliot Cyril , Campamà Pizarro Rafael , Compagnon Raphaël , Czachura Agnieszka , Desthieux Gilles , Formolli Matteo , Giroux-Julien Stéphanie , Guillot Victor , Govehovitch Benjamin , Hachem-Vermette Caroline , Herman Ellis , Alarcon Herrera Olivia , Kämpf Jérôme , Lobaccaro Gabriele , Ménézo Christophe , Peronato Giuseppe , Jonas Petersen Arnkell , Rodler Auline , Singh Kuljeet , Sjöberg Viktor , Snow Mark , Tjetland Joar , Wang Yupeng , Thebault Martin 
Published: October 2022

Planning for sustainable neighborhoods is a high priority for many cities. It is therefore important to take the right decisions during the planning phase to ensure that important aspects are considered. One of these important aspects is to consider the harvesting of solar energy in the best possible way. It is however difficult to define the best ways to exploit the incoming solar energy. Solar energy can be used by means of active solar energy production, passively by means of daylighting buildings or outside buildings on the ground for direct solar access or thermal comfort. This different usage can sometimes be conflicting (for example at a building level, in order to maximize the photovoltaic production, it may be necessary to use all the surfaces, therefore preventing the access to daylight). The access to daylight in the street is appreciated during cold days, but shading is preferred during the hotter days.
Protections and Social Support of Exclusive Breastfeeding for Mothers with COVID-19: Message for Health Promotion during The Pandemic
Authors: Khairunnisaa Khairunnisaa , Ayubi Dian 
Published: October 2022

Introduction: The COVID-19 pandemic is a concern regarding the potential failure of exclusive breastfeeding in mothers with COVID-19. This study reviews previous research describing the protective and social support practices of exclusive breastfeeding in mothers with COVID-19.Methods: A systematic search was conducted in March-June 2021 using databases such as Scopus and PubMed with a deadline of 2020-2021 that met the inclusion criteria. 462 articles which were then entered in the elimination stage until the final 16 articles were eligible for a full text review. Study quality was assessed using the Newcastle-Ottawa Scale (NOS).Results: We identified 16 studies reporting 1,865 cases of maternal infection with COVID-19. An overview of breastfeeding protection practices is carried out through rooming-in and post-delivery skin contact. This practice includes implementing strict precautions such as wearing a mask, social distancing, and maintaining hand and breast hygiene. All babies born to mothers who practice breastfeeding protection are not infected with COVID-19. Social support from health workers, families and health care management cannot be overlooked in ensuring breastfeeding continues and precautions are followed. Conclusion: In mothers with COVID-19 breastfeeding is still recommended but must be supported by strict health protocols. Social support cannot be neglected to protect exclusive breastfeeding practices and ensure that COVID-19 precautions are adhered to.
ENSINO DE GEOGRAFIA E O ESTUDO DA POPULAÇÃO BRASILEIRA
Authors: Manfio Vanessa 
Published: October 2022

Na contemporaneidade, cada vez mais, o ensino de Geografia tem por desafio motivar os alunos a aprender, partindo da contextualização do conteúdo com a realidade dos estudantes. Não é possível oferecer um ensino bancário como diz Paulo Freire, isto é, de repetição de conceitos, pois este não agrada mais os educandos. A Geografia tem na essência uma interconexão com o local e pode ser trabalhada em diferentes abordagens. Pensando no ensino da diversidade regional da cultura da população brasileira, buscou-se propor uma prática didática que dialoga com o conteúdo e as festas juninas, sendo proposta a construção de maquetes, para sinalizar o conhecimento e trazer o aluno para aula, para sua aprendizagem por meio de metodologias ativas. A intervenção pedagógica aconteceu em junho de 2020, com os alunos do 7º ano do Ensino Fundamental da Escola Municipal de Ensino Fundamental Professora Cândida Zasso de Nova Palma - RS. Com a atividade foi possível observar o interesse e participação dos alunos, a criatividade e conteúdo das produções e, por fim, articular o ensino de Geografia a realidade dos mesmos.
WITHDRAWN: Temperature modeling and experimental analysis of high speed milling titanium alloy
Authors: Zhao Na , Su Yingxin , Liu Jianping , Liu Kuo , Liu Changfu 
Published: October 2022

Abstract
Titanium alloy is widely used in aerospace and other fields because of its high strength, low density, good corrosion resistance and high temperature resistance. In high speed milling titanium alloy, due to the poor thermal conductivity of titanium alloy and the change of cutting mechanism caused by high speed machining, it is great significance to study the cutting temperature in high speed milling process. Based on the moving heat source method, the temperature field model of milling workpiece considering spiral edge was established, and the influence of milling speed on workpiece temperature was analyzed through the change of heat flux during milling. The thermocouple wireless temperature acquisition system was used to record the change of workpiece surface temperature in the milling process, and MATLAB was used for the simulation analysis of milling temperature. The results showed that the cutting speed mainly affected the heat flux of the heat source, thereby caused temperature rise of the workpiece. The peak temperature and response speed of measuring point are different in varying spindle speeds and measuring point positions.
Bioconcentration and Tolerance Mechanism of a Trichoderma Strain Exposed to Cobalt, Strontium, and Uranium
Authors: Li Jian , Lai Jinlong , Li Zhanguo , Xi Hailing 
Published: October 2022

Abstract
Microbial enrichment of radionuclides has the advantages of low cost, simple operation, and no secondary pollution, but the enrichment abilities of radionuclides differ. In this study, a Trichoderma fungus with high tolerance to a variety of radionuclides [i.e., cobalt (Co), strontium (Sr), and uranium (U)] was screened from radioactive contaminated soil by analyzing the enrichment characteristics. Combined with non-targeted metabolomics technology, the physiological response mechanism of Trichoderma fungus metabolism to cobalt, strontium and uranium exposure was revealed from the metabolic level. The results showed that the Trichoderma grew well under multi-nuclides exposure, and the Co, Sr, and U accumulated on the mycelium surface of the strain. Their enrichment reached 36.4–96.6 mg/kg, 76.7–239.7 mg/kg, and 268.5–667.0 mg/kg, respectively. With the increase in the multi-nuclides exposure concentration, the element metabolism of the strain changed, and U, Co, and Sr showed a cooperative absorption relationship. The gas chromatograph-mass spectrometer (GC-MS) non-targeted metabolome analysis showed that the amino acid metabolic pathway and the carbohydrate pathway of the strain changed when the Co, Sr, and U concentrations were 100 mg/L. The results showed that Trichoderma has strong enrichment potential and tolerance to Co, Sr, and U and can be used for radionuclide removal.