bluuebunny/crossref_metadata_2025_split huggingface dataset:
An assessment of prevalence of Type 1 CFI rare variants in European AMD, and why lack of broader genetic data hinders development of new treatments and healthcare access
Authors: Jones Amy V. , Curtiss Darin , Harris Claire , Southerington Tom , Hautalahti Marco , Wihuri Pauli , Mäkelä Johanna , Kallionpää Roosa E. , Makkonen Enni , Knopp Theresa , Mannermaa Arto , Mäkinen Erna , Moilanen Anne-Mari , Tezel Tongalp H. ,   on behalf of the SCOPE Study group, Waheed Nadia K. 
Published: September 2022

Purpose
Advanced age-related macular degeneration (AAMD) risk is associated with rare complement Factor I (FI) genetic variants associated with low FI protein levels (termed ‘Type 1’), but it is unclear how variant prevalences differ between AMD patients from different ethnicities.

Methods
Collective prevalence of Type 1 CFI rare variant genotypes were examined in four European AAMD datasets. Collective minor allele frequencies (MAFs) were sourced from the natural history study SCOPE, the UK Biobank, the International AMD Genomics Consortium (IAMDGC), and the Finnish Biobank Cooperative (FINBB), and compared to paired control MAFs or background population prevalence rates from the Genome Aggregation Database (gnomAD). Due to a lack of available genetic data in non-European AAMD, power calculations were undertaken to estimate the AAMD population sizes required to identify statistically significant association between Type 1 CFI rare variants and disease risk in different ethnicities, using gnomAD populations as controls.

Results
Type 1 CFI rare variants were enriched in all European AAMD cohorts, with odds ratios (ORs) ranging between 3.1 and 7.8, and a greater enrichment was observed in dry AMD from FINBB (OR 8.9, 95% CI 1.49–53.31). The lack of available non-European AAMD datasets prevented us exploring this relationship more globally, however a statistical association may be detectable by future sequencing studies that sample approximately 2,000 AAMD individuals from Ashkenazi Jewish and Latino/Admixed American ethnicities.

Conclusions
The relationship between Type 1 CFI rare variants increasing odds of AAMD are well established in Europeans, however the lack of broader genetic data in AAMD has adverse implications for clinical development and future commercialisation strategies of targeted FI therapies in AAMD. These findings emphasise the importance of generating more diverse genetic data in AAMD to improve equity of access to new treatments and address the bias in health care.
(Meta)Lexicografia e Terminografia
Authors: Galvão Patrícia Medeiros da Silva 
Published: September 2022

Trata-se de uma resenha da obra (Meta)Lexicografia e Terminografia, de autoria de Adja Balbino de Amorim Barbieri Durão, Aylton Barbieri Durão e María Àngeles Sastre Ruano, publicada em 2020 pela Pontes Editores.
RUSS, Jacqueline. Os Metodos em Filosofia. Tradução de Gentil Avelino Titton. Petrópolis: Vozes, 210
Authors: Piovezan Gustavo 
Published: September 2022

Discutir métodos em filosofia não é algo comumente promovido em cursos de graduação. O filosofar, tal como se faz na academia, exige um tipo de escrita e linguagem próprias, uma técnica. Os empecilhos que os alunos enfrentam é uma realidade que muitos professores verificam em salas de aula e avaliações, sobretudo nos primeiros anos de curso. Em geral, as dificuldades manifestam-se tanto na escrita da dissertação filosófica, como no comentário filosófico. Tais dificuldades, entretanto, são sanadas com o auxílio do método – que ensina ou indica possibilidades ao estudante – criando um percurso a ser efetuado para a elaboração, o desenvolvimento e a solução de um determinado problema. Assim, em Filosofia, o método apresentar-se-ia como uma proposta reflexiva e não dogmática ante um fenômeno observado no ensino e cuja importância é vital para a sobrevivência do filosofar: a reflexão e a escrita filosóficas.
Motivada por esse problema, Jacqueline Russ escreveu a obra Les méthodes en philosophie, traduzido para o português em 2010 sob o título de Os métodos em filosofia. É interessante destacar que a obra foi composta com base na docência efetuada pela autora na França. Deste modo, semelhante aos manuais didáticos, o texto de Russ faz uma apresentação daquilo que seria uma teoria do método em filosofia, fornecendo, inclusive, técnicas de pesquisa e escrita filosóficas. Para tanto, fundamenta-se no pensamento de Descartes, Hegel e, por fim, na teoria retórica. Em Descartes, o método da análise e síntese é evocado como meio para se pensar conceitos filosóficos. Deste modo, o encadeamento lógico torna-se evidente, apresentando o caráter demonstrativo do texto.
HUBUNGAN ANTARA INTERNET ESCAPISM DAN KECENDERUNGAN KECANDUAN INTERNET DENGAN RESILIENSI ONLINE SEBAGAI MODERATOR PADA REMAJA DI SMA N 4 KOTA BEKASI
Authors: Sukindro Sabastian Yustiano , Kaloeti Dian Veronika Sakti 
Published: September 2022

Tujuan dari penelitian ini adalah mengkaji hubungan antara internet escapism dengan kecenderungan kecanduan internet serta menguji apakah resiliensi online dapat berperan sebagai moderator. Penelitian ini melibatkan 219 remaja dari SMA N 4 Kota Bekasi kelas X, XI, dan XII sebagai partisipan penelitian. Metode pengumpulan data menggunakan Skala Kecenderungan Kecanduan Internet (27 butir, = 0,896), Skala Internet Escapism (9 butir, = 0,835), dan Skala Resiliensi Online (12 butir, = 0,707). Teknik analisis data menggunakan analisis regresi linier sederhana dan analisis regresi moderasi. Hasil uji menunjukkan bahwa internet escapism memiliki hubungan positif dengan kecenderungan kecanduan internet (rxy = 0,525) dan dapat menjadi prediktor yang signifikan, b = 1,240, t(217) = 9,077, p < 0,05; F(1, 217) = 82,391, p < 0,05. Internet escapism dapat menjelaskan variasi kecenderungan kecanduan internet sebanyak 27,5%. Resiliensi online tidak dapat menjadi moderator pada hubungan antara internet escapism dan kecenderungan kecanduan internet (p = 0,843, p > 0,05), namun berperan signifikan secara independen sebagai faktor promotif dalam model compensatory, b = -0,693, t(216) = -5,233, p < 0,05. Model compensatory adalah model di mana faktor promotif berperan negatif dan signifikan secara independen terhadap luaran negatif. Kesimpulan dari penelitian ini adalah internet escapism memiliki hubungan dengan kecenderungan kecanduan internet dan resiliensi online tidak signifikan berperan sebagai moderator.
Sintesis Elektroda Lapis Tipis Sn–Zno/FTO Secara Elektrodeposisi dan Aplikasi pada Degradasi Remazol Black B (RBB
Authors: Fardhani Dea Ayu , Haris Abdul , Suyati Linda , Widodo Didik Setiyo 
Published: September 2022

Elektroda Lapis Tipis yang telah berhasil disintesis pada penelitian ini melalui elektrodeposisi menghasilkan ZnO terdoping Sn pada kaca FTO yang diharapkan dapat berfungsi sebagai fotokatalis. Prekursor yang digunakan merupakan larutan elektrolit yang dapat menghasilkan ZnO sebagai semikondutor dan Sn sebagai doping logam yang dapat menurunkan band gap ZnO. Elektroda hasil sintesis dikarakterisasi menggunakan Difraksi Sinar-X (XRD) untuk mengetahui struktur dan ukuran kristal serta keberadaan senyawa secara kualitatif yang dibandingkan dengan literatur. Pada Aplikasi, •OH yang dihasilkan pada permukaan elektroda setelah penyinaran foton dapat mendegradasi zat warna RBB yang terdapat pada limbah tekstil secara fotokatalisis maupun fotoelekroktalisis. Penurunan konsentrasi serta absorbansi RBB dianalisis menggunakan spektrofotometer UV-Vis.
Kualitas Air dan Sedimen di Pusat Informasi Mangrove (PIM), Pekalongan
Authors: Pratiwi Fransiska Krisna Wahyu Nanda , Maslukah Lilik , Sugianto Denny Nugroho 
Published: September 2022

Kualitas perairan berkaitan dengan kondisi lingkungan setempat ditambah adanya peranan dari ekosistem mangrove di Pusat Informasi Mangrove (PIM), Pekalongan yang mampu menyimpan karbon lebih tinggi, sehingga perlu dilakukan uji parameter kualitas perairan dan uji sedimen. Penelitian ini bertujuan untuk membandingkan nilai dari kualitas perairan berupa salinitas, suhu, pH, DO, TSS, total fosfat, dan nitrat dengan nilai baku mutu, serta menghitung kandungan Karbon Organik Total (KOT) dan ukuran butir sedimennya. Titik sampel ditentukan secara purposive. Pengujian total fosfat menggunakan metode SNI 06.6989.31.2005, nitrat menggunakan metode SNI 06.2480.1991, TSS menggunakan metode SNI 06.6989.3.2004, dan parameter lainnya merupakan parameter sedangkan KOT sedimen menggunakan metode %LOI dan ukuran butir sedimen menggunakan metode dry sieving dan wet sieving. Hasil penelitian ini menunjukkan nilai-nilai dari kualitas perairan masih batas aman untuk kawasan mangrove, sedangkan untuk KOT berkisar antara 2,8% - 10,5% dengan ukuran butir sedimen dominan berupa pasir dan lanau. Kata kunci : Kualitas air; Sedimen, Karbon Organik Total, Pusat Informasi Mangrove, Pekalongan AbstractWater quality is related to the surrounding environmental condition. The role of the mangrove ecosystem in Pusat Informasi Mangrove (PIM), Pekalongan, is to store carbon in high numbers. Thus, a water quality parameter and sediment examination are necessary.This research aims to compare water quality values in terms of salinity, temperature, pH, DO, TSS, total phosphate, nitrate, with existing quality standards and calculate Total Organic Carbon (TOC) content and grain size of the sedimentThe sample point was determined purposively. The total phosphate examination applied SNI 06.6989.31.2005 method, nitrate examination applied SNI 06.2480.1991 method, and TSS examination applied SNI 06.6989.3.2004 method. The other parameters are located in-site, while TOC used the %LOI method and grain size of sediment used dry sieving and wet sieving method. The result confirmed that the water quality values in the mangrove area are still within the safe limits, while the TOC ranged from 2,8% to 10,5%, with the dominant sediment grain size in the form of sand and silt.Keywords : Water quality; sediment, Total Organic Carbon, Mangrove Information Center, Pekalongan
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN ANGKA KUMAN PADA PERALATAN MAKAN DI RUMAH MAKAN WILAYAH PERIMETER DAN BUFFER AREA PELABUHAN SAMPIT
Authors: Cholid Khafid Anwar , Darundiati Yusniar Hanani , Sulistiyani Sulistiyani 
Published: September 2022

Sampit Seaport is a berth for various kinds of ships, including passenger ships, cargo ships, Crude Palm Oil ships. In 2019 of 15 eating utensil that was inspected the number of germs as many as 13 eating utensil unqualified of health and there are reports 1 prospective ship passenger who experienced diarrhea during Lebaran homecoming. Monitoring the bacteriological quality of eating utensil is one of the keys to prevent foodborne diseases. This study aims to determine the factors associated to the number of bacteria on eating utensil including washing water, eating utensil materials, eating utensil washing techniques, eating utensil drying techniques and eating utensil storage at Sampit Seaport. This was an observational study with a cross-sectional design. The population in this study were all of the eating utensil in 10 restaurants located in the perimeter and buffer area of the Sampit Seaport. The number of samples in this study were 60 eating utensil. Data analysis was univariate and statistical test using the Pearson Chi Square. The results showed that 28 (46.67%) did not meet the bacteriological requirements. The results of statistical analysis showed that there was a association between washing water (p=0.013), The results showed that 46.67% is unqualified the bacteriological requirements storage (p=0.001) to the total plate number on eating utensil. In addition, there was no association between eating utensil material (p=0.560), washing technique (p=0.174), and drying technique (p=0.174) with the Total Plate Number on eating utensil. It can be concluded that there was a associationbetween washing water and storage of eating utensil to total palre count on eating utensil. Suggestions for restaurants is to pay attention of sanitation hygiene to eating utensil that used in the restaurant.
GAMBARAN PERBEDAAN KARATERISTIK PETUGAS PUSKESMAS DENGAN CAKUPAN PENEMUAN PNEUMONIA BALITA TERTINGGI DAN TERENDAH (STUDI 10 PUSKESMAS KABUPATEN TEMANGGUNG)
Authors: Hasyanah Uswatun , Yuliawati Sri , Hestiningsih Retno 
Published: September 2022

Pneumonia is a process of acute infection associated with lung tissue (alveoli), which is one of the biggest causes of child death in the world. One of the efforts made by the government is to reduce the incidence of toddler pneumonia by carrying out a program of finding toddler pneumonia. Toddler pneumonia discovery program has a target that has been set nationally. Community Health Centers in Temanggung Regency have very significant differences in coverage of toddler pneumonia findings between primary healthcare that have reached and have not yet reached the target.The purpose of this study was to describe the diferences officer factors in public health centers with high and low coverage of infant pneumonia findings in Temanggung Regency.This type of research uses observational analytics using cross sectional methods. The sample of this study was 10 primary Healthcare Temanggung District. The results of the study the difference between high and low coverage health centers, the knowledge factor of officers was 72.0% and 62.0%, the motivation of the officers was 64.0% and 73.0%, the activeness of officers was 64.0% and 73.0%, work officers are 80.0% and 100.0%. Published to the Health Office to refresh knowledge about toddler pneumonia to harmonize understanding of toddler pneumonia and how to detect toddler pneumonia.
ANALISIS STRATEGI PELAKSANAAN PROGRAM RUMAH SAKIT TANPA DINDING (HOSPITAL WITHOUT WALLS) DI RSJD DR. AMINO GONDOHUTOMO PROVINSI JAWA TENGAH MENGGUNAKAN MATRIKS SWOT DAN QSPM
Authors: Pratiwi Cika Hanjani , Jati Sutopo Patria , Arso Septo Pawelas 
Published: September 2022

The variety of health problems in Central Java is that there are not yet optimal public health efforts held in primary healthfacilities, like as Puskesmas in promotive and preventive services. According to this problem, the Governor of Central Java for the 2018-2023 period launched an innovation program, namely the Hospital Without Walls (HWW) which aims to strengthen public health efforts and empower the community. RSJD Dr. Amino Gondohutomo is one of the seven provincial hospitals that implemented the HWW. In two years of implementing HWW, an evaluation and improvement strategy is needed. So the purpose of this study is to describe and analyze strategies in an effort to optimize the implementation of HWW. This research is a qualitative research using descriptive method through in-depth interviews, informants were selected based on purposive sampling technique. The main informants are the Director, Deputy Director of Services, Head of Medical Services, Manager of Patient Services, and Head of Planning and Education Division. Triangulation informants are the health promotion leader and members of the HWW coordinating team. The results showed that internal factors in the form of strengths and weaknesses, as well as external factors such as opportunities and threats in the implementation of the HWW. The implementation of the HWW is in quadrant 3, which is a turn around strategy. Where this strategy minimizes internal weaknesses to take advantage of existing opportunities. Alternative strategies that can be implemented is to equate perceptions of understanding and positive mental attitudes for directors, managerial, and hospital staff.
FAKTOR YANG BERHUBUNGAN DENGAN PERILAKU SEKSUAL REMAJA AWAL DI LINGKUNGAN PROSTITUSI BANDUNGAN KABUPATEN SEMARANG
Authors: Maulidya Isnaini , Musthofa Syamsulhuda Budi , Indraswari Ratih 
Published: September 2022

Adolescents who lived in prostitution complex have unhealthy condition of environment that can affect their development, morality, and form improperly behavior. This study aimed to determine factors correlated with early adolescent sexual behavior in prostitution complex of Bandungan. This was an analytic-descriptive study with cross sectional study design. This study included 60 samples of early adolescents in Bandungan (10-14 years old) who were selected using proportional random sampling technique. Data were obtained from interview and online survey. Chi square analysis showed parents’ job (p=0,037), environment (p=0,025), and quality of sexuality communication with parents (p=0,002) had significant correlation with adolescent sexual behavior. Knowledge about sexuality (p=0,750) and frequency of sexuality communication with parents (p=0,768) were not significantly correlated with adolescent sexual behavior.Therefore, findings suggest local government and community to create a healthy environment by holding positive activities and enacting regulations that support children protection as well as parents should improve the quality of sexuality communication with their children.
PERENCANAAN KEHAMILAN SEHAT PADA CALON PENGANTIN PEREMPUAN YANG BERNIAT MENIKAH USIA DINI DI KABUPATEN SEMARANG TAHUN 2020
Authors: Kusumaning Pertiwi Niki Ayu , Indraswari Ratih , Husodo Besar Tirto 
Published: September 2022

One of the factors of the high-risk pregnancy complication is caused by the young age of pregnant women (<20 years old). Lack of knowledge about complications of high-risk pregnancy caused the high number of complication pregnancy cases of adolescent girls in Sumowono, Bandungan, Bergas, and Jambu districts. This research aimed to describe how the practice of healthy pregnancy planning in adolescent girls who get early married. The method of this research was analytic quantitative with a cross-sectional design. The populations were 50 women bride-to-be that less than 19 years old who registered in KUA Sumowono, KUA Bandungan, KUA Bergas, dan KUA Jambu and will marry in August and September 2020. The samples were 50 women bride-to-be were selected using total population sampling. This research used univariate and bivariate analysis. The result of univariate analysis showed that most of the respondents were aged 18 years old, respondent’s education are a senior high school, respondent’s income is low income, and respondent’s occupation is laborer. The result of the chi-Square test showed that there is a relation between knowledge (p=0.000), attitude (p-value=0.013), and access to information (p-value=0.007) with the practice of healthy pregnancy planning. Meanwhile, there is no relation between family support (p=0.661), health worker support (p=0.490), future husband support (p=0.793), respondents’s age (p=0.302), respondent’s occupation (p=0.058), respondent’s education (p=0.963), respondent’s income (p=0.851), father’s education (p=0.011), mother’s education (p=0.960), father’s occupation (p=0.413), mother’s occupation (p=0.485), father’s income (p=0.902), and mother’s income (p=0.767).
LITERATUR REVIEW : APA SAJA FAKTOR RISIKO KEBERADAAN BAKTERI ESCHERICHIA COLI PADA ES BATU?
Authors: Dipta Mahotama Kumara , Budiyono Budiyono , Yunita Dewantii Nikie Astorina 
Published: September 2022

Es merupakan hasil pembekuan air yang sering di temukan pada pedagang kaki lima hingga restoran, tetapi es yang dikonsumsi dapat menjadi sumber kontaminasi oleh mikoorganisme patogen Escherichia coli atau coliform. Keberadaan bakteri pada es ini dapat menyebabkan penyakit diare. Tujuan penelitian ini yaitu mengetahui faktor keberadaan bakteri Escherichia coli pada es yang dijual pedagang. Penelitian ini menggunakan metode literatur review. Penelusuran artikel dilakukan melalui database Google Scholar, Mendeley, DOAJ, dan Jurnal Kesehatan Masyarakat, pada bulan Mei 2020. Artikel yang digunakan adalah artikel dengan desain penelitian obsevasional. Hasil penelitian menemukan 12 artikel yang dikaji. Terdapat 83% yang menyatakan bahan baku air yang tidak matang dan 67% hygiene sanitasi juga dapat berpengaruh bakteri Escherichia coli pada es. Bahan baku menjadi faktor utama dalam mempengaruhi keberadaan Bakter Escherichia coli pada es.
An Evaluation of Psychometric Properties of Needs Assessment Instruments in Patients with Coronary Artery Disease Undergoing Cardiac Rehabilitation Programs: A Systematic Review
Authors: Zarea Kourosh , Mohammadi Eesa , Alteren Johanne , Sayadi Neda 
Published: September 2022

Background: Coronary Artery Disease is the foremost reason of illnesses and death in the world. Assessment of the needs is a priority in these patients. However, there is a paucity of tools for the evaluation of needs, with the controversy surrounding their validity.Purpose: This review aimed to evaluate the psychometric properties of tools used to assess needs of patients with CAD undergoing cardiac rehabilitation (CR) plans.Methods: An online literature search combined with manual search was carried out on 11 databases to identify relevant articles. The terms used in the search were: cardiac rehabilitation AND coronary artery disease, cardiac rehabilitation AND acute coronary syndrome, and questionnaires OR need assessment OR tool OR scale. Articles from 1989 to 2021 were selected using some inclusion criteria and no validation studies were excluded. The quality of the questionnaires was evaluated by researchers using consensus-based standards for the selection of health status measurement instruments (COSMIN) list. Data analysis had been done by calculating overall methodological quality scores per study on a measurement property using COSMIN checklist. A methodological quality score per box was obtained by taking the lowest rating of any item in a box (‘worse score counts’).Results: Of 653 articles, 15 papers were involved in the study. Six studies reported cross-cultural validity, nine studies for criterion validity, and none reported measurement error, hypothesis testing, and responsiveness. There is no vigorous and valid single scale for the measurement of needs in CAD patients Overall, the CADEQ questionnaire was good and a patient self-assessment tool for cardiac rehabilitation was poor based on psychometric properties.Conclusions: The findings of this study disclosed that even though it has been more than 32 years, from 1989 to 2021, of the development in need assessment instruments; each instrument has as a minimum of one “poor” psychometric property according to the COSMIN checklist. So, it is recommended for the next studies to design and develop instruments with better psychometric validities for clinical environment.