bluuebunny/crossref_metadata_2025_split huggingface dataset:
The sandwich effect in L3 acquisition: A look at the Catalan and Spanish grammars of highly advanced speakers of L3 English
Authors: Puig-Mayenco Eloi 
Published: November 2022

Aims and objectives: This study examines the extent to which the acquisition of a highly advanced third language (L3) will affect previously (early) acquired languages. We directly test the main tenets of the differential stability hypothesis. Design/method/approach: We test 72 Catalan–Spanish bilinguals divided across four groups using two dimensions: (a) order of acquisition and (b) proficiency/exposure in L3 English. We administered two self-paced reading tasks (one in Catalan and the other in Spanish) to explore their processing of negative concord items. Data analysis: Using generalized linear mixed-effects models, we analysed the effect English had on the processing of negative concord items in Catalan and Spanish in three different conditions of interest. Findings/conclusions: The results partially confirm the tenets of the differential stability hypothesis (DSH). We show that first language (L1) and second language (L2) are differentially affected by the acquisition of an L3. We further show that there are different degrees of vulnerability for different syntactic contexts in an L2. We propose a novel effect in the study of L3 regressive effects that can complement the tenets of the DSH: the sandwich effect in L3 acquisition. Originality: The study provides the first empirical investigation of the tenets of the DSH. Significance/implications: This study offers a new effect in L3 acquisition and we put forward how we can test it and propose new directions to explore regressive transfer effects.
Differences among physical activity actigraphy algorithms in three chronic illness populations
Authors: Alder Megan L , Still Carolyn H , Wierenga Kelly L , Pignatiello Grant A , Moore Shirley M 
Published: November 2022

Objectives In three chronic illness populations and in a combined sample, we assessed differences in two algorithms to determine wear time (WT%) and four algorithms to determine: Kilocalories, light physical activity (PA), moderate-to-vigorous PA (MVPA), and metabolic equivalents (METs). Methods Data were collected from 29 people living with HIV (PLHIV), 27 participants recovering from a cardiac event, and 15 participants with hypertension (HTN). Participants wore the ActiGraphTM wGT3X-BT for > 3 days on their hip. Analysis of variance (ANOVA) was used to assess differences among the algorithms. Results No differences were found between the two algorithms to assess WT% or among the four algorithms to assess kilocalories in each of the chronic illness populations or in the combined sample. Significant differences were found among the four algorithms for light PA ( p < .001) and METs ( p < .001) in each chronic illness population and in the combined sample. MVPA was significantly different among the four algorithms in the PLHIV ( p = .007) and in the combined sample ( p < .001), but not in the cardiac ( p = .064) or HTN samples ( p = .200). Discussion Our findings indicate that the choice of algorithm does make a difference in PA determination. Differences in algorithms should be considered when comparing PA across different chronic illness populations.
Performance of ICD-10-AM codes for quality improvement monitoring of hospital-acquired pneumonia in a haematology-oncology casemix in Victoria, Australia
Authors: Valentine Jake C , Gillespie Elizabeth , Verspoor Karin M , Hall Lisa , Worth Leon J 
Published: November 2022

Background The Australian hospital-acquired complication (HAC) policy was introduced to facilitate negative funding adjustments in Australian hospitals using ICD-10-AM codes. Objective The aim of this study was to determine the positive predictive value (PPV) of the ICD-10-AM codes in the HAC framework to detect hospital-acquired pneumonia in patients with cancer and to describe any change in PPV before and after implementation of an electronic medical record (EMR) at our centre. Method A retrospective case review of all coded pneumonia episodes at the Peter MacCallum Cancer Centre in Melbourne, Australia spanning two time periods (01 July 2015 to 30 June 2017 [pre-EMR period] and 01 September 2020 to 28 February 2021 [EMR period]) was performed to determine the proportion of events satisfying standardised surveillance definitions. Results HAC-coded pneumonia occurred in 3.66% ( n = 151) of 41,260 separations during the study period. Of the 151 coded pneumonia separations, 27 satisfied consensus surveillance criteria, corresponding to an overall PPV of 0.18 (95% CI: 0.12, 0.25). The PPV was approximately three times higher following EMR implementation (0.34 [95% CI: 0.19, 0.53] versus 0.13 [95% CI: 0.08, 0.21]; p = .013). Conclusion The current HAC definition is a poor-to-moderate classifier for hospital-acquired pneumonia in patients with cancer and, therefore, may not accurately reflect hospital-level quality improvement. Implementation of an EMR did enhance case detection, and future refinements to administratively coded data in support of robust monitoring frameworks should focus on EMR systems. Implications Although ICD-10-AM data are readily available in Australian healthcare settings, these data are not sufficient for monitoring and reporting of hospital-acquired pneumonia in haematology-oncology patients.
Sustained Impact of a Postgraduate Residency Training Program on Nurse Practitioners’ Careers
Authors: Hart Ann Marie , Seagriff Nicole , Flinter Margaret 
Published: November 2022

Introduction: In 2007, the first formal postgraduate nurse practitioner (NP) residency program was launched at Community Health Center, Inc., a large Federally Qualified Health Center in Connecticut, and focused on primary care and community health. There are numerous post-graduate nurse practitioner training programs across the nation, and many more are under development. Although the literature describes the impact of postgraduate residency training programs on new NPs’ early practice transition, to date, no studies have examined the long-term impact of postgraduate NP training programs on alumni’s career choices, practice, and satisfaction. This study sought to understand the impact over time of Community Health Center Inc.’s postgraduate NP residency program on the subsequent career paths of alumni who completed the program between 2008 and 2019. Additionally, it explored alumni’s current reflections on the impact of their postgraduate residency training on their transition to the post-residency year and beyond, as well as their professional development and career choices. Moreover, it sought to identify any previously undocumented elements of impact for further exploration in subsequent studies. Methods: This was a retrospective cohort study that used an electronic survey and interviews. All 90 of the alumni who had completed Community Health Center Inc.’s residency between 2008 and 2019 were invited to participate. Results: The survey’s response rate was 72%. Most (74%) of the participating alumni indicated they were still practicing as primary care providers. Of these, 57% were practicing at FQHCs. Nine subthemes were identified from the interviews, with an overarching theme that the program was foundational to a successful career in community-based primary care and that the impact of the program continues to evolve. Conclusion: Community Health Center Inc.’s postgraduate NP residency program had a long-standing impact on alumni’s commitment to continuing in primary care practice, as well as their engagement in leadership activities to ensure quality care.
Durability and Safety of Deep Peroneal Nerve Neurectomy for Midfoot Arthritis at Midterm Follow Up
Authors: Iturregui Jose M. , Haupt Edward T. , Wilke Benjamin , Kraus Jonathan C. , Shi Glenn G. 
Published: November 2022

Category: Midfoot/Forefoot Introduction/Purpose: Midfoot osteoarthritis affects up to 12% of the adult population greater than 50 years old. Arthrodesis is the traditional surgical procedure performed when nonoperative management fails but is a technically demanding procedure that requires prolonged postoperative immobilization and is not uncommonly complicated by nonunion or deep infection. The deep peroneal nerve (DPN) plays a significant role in afferent nociceptive midfoot joint pain perception, most consistently in the second and third tarsometatarsal joints and the naviculocuneiform joint. Early outcomes following DPN neurectomy have demonstrated promising results as a safe and effective treatment that allows early mobilization and weight bearing. The purpose of our study was to evaluate the mid-term patient satisfaction and pain relief after DPN neurectomy for treatment of chronic midfoot pain due to osteoarthritis. Methods: In this retrospective IRB-approved questionnaire-based study, we evaluated 49 out of 95 patients identified (56 feet) with an average follow-up of 34.6 (range, 9 to 51) months, who underwent DPN neurectomy (Figure 1) at our institution between September 2017 and February 2021. There were 39 women and 10 men, 42 unilateral (23 right, 19 left) and 7 bilateral procedures, with an average age of 67.9 (range, 35 to 88) years at the time of surgery. A questionnaire which included questions regarding post-surgical dorsal midfoot pain relief, surgical result satisfaction, and current functional limitations was administered via telephone. Demographic information, patient responses, and complications were recorded. Results: There was an 81.2% patient satisfaction with the result of the surgery in relieving their dorsal midfoot pain. Of the 49 patients, 84.9% would repeat the surgery under the same circumstances, 84.1% would recommend the surgery to a friend, 10.2% reported they wish they had undergone arthrodesis, 8.2% reported no pain relief in the first 6 months, and 55.8% reported current activity limitations because of dorsal midfoot pain. Six feet (10.7%) underwent a second procedure with an average postoperative time of 20.5 (range, 1 to 36) months. Complications include one patient with deep wound infection, one DPN neurectomy revision and burial into bone, one DPN neuroma excision, one midfoot exostosis excision, and two conversions to arthrodesis. Theoretic complications of neuroarthropathy, midfoot collapse, and development of lesser toe deformities were not observed. Conclusion: DPN neurectomy is a safe and effective surgical option for the management of chronic dorsal midfoot pain due to midfoot osteoarthritis after failed nonoperative management. At midterm follow-up, patients who underwent dorsal midfoot denervation reported acceptable satisfaction rates, similar to those reported for arthrodesis, with associated improved functional outcomes and few complications.
Outcome of Conversion to Fusion for a Failed Ankle Replacement: A Data Linkage Study using the National Joint Registry and NHS Digital
Authors: Jennison Toby , Sharpe Ian T. , Goldberg Andrew J. 
Published: November 2022

Category: Ankle Arthritis Introduction/Purpose: There are limited studies on the outcomes of conversion to fusion following a failed ankle replacement. The primary aim of this NJR data linkage study is to determine the outcomes of conversion to fusion following a failed ankle replacement. Methods: A data linkage study combined National Joint Registry Data and NHS Digital data. The primary outcome of failure is defined as a further fusion procedure or amputation. Life tables and Kaplan Meier survival charts demonstrated survivorship. Cox proportional hazards regression models with the Breslow method used for ties were fitted to compare failure rates. Results: 131 patients underwent conversion to fusion. The mean time from primary replacement was 33.8 months (range 1-100). The mean age was 63.3 (range 33-85), there were 73 males (55.7%). The mean BMI was 30.7 (SD 5.3) mean ASA was 2.0 and the mean Charlson co-morbidity score was 2.5. The most commonly revised implant was the Mobility in 45.0%, Zenith in 16.8% and Box in 11.5%.105 (80.2%) were as a single stage and 26 (19.8%) as a 2 stage procedure. The 1 year survivorship was 96.0% (95% CI 90.6%-98.3%), 2 year survivorship was 83.8% (95% CI 75.4%-89.5%) and 5 year survivorship was 72.4% (95% CI 62.0%-80.4%) A Cox regression model adjusting for individual factors did not find any risk factor significantly increased the risk of failure. Conclusion: Conversion to fusion following a failed ankle replacement has high rates of further surgery. Further prospective studies are required to determine risk factors for failure to improve outcomes for these patients.
Histone deacetylase-6 modulates the effects of 4°C platelets on vascular endothelial permeability
Authors: Miyazawa Byron , Trivedi Alpa , Vivona Lindsay , Lin Maximillian , Potter Daniel , Nair Alison , Barry Mark , Cap Andrew P. , Pati Shibani 
Published: November 2022

AbstractPlatelets (PLTs) stored at 4°C exhibit equivalent or superior hemostatic function compared with 22°C PLTs, but have shorter circulation times and a decreased ability to modulate vascular permeability. These differences may be due to morphological changes and storage-induced activation. Using a proteomics-based approach, we found that 4°C-stored PLTs express decreased α-tubulin, a key PLT structural protein. PLT activation is characterized by α-tubulin deacetylation, which is regulated by histone deacetylase-6 (HDAC-6). We hypothesized that inhibition of HDAC-6 in stored PLTs will improve their ability to regulate vascular permeability through reduced activation and α-tubulin deacetylation. In an in vivo model of vascular permeability, treatment of 4°C PLTs with the HDAC-6 inhibitor tubacin enhanced the vasculoprotective properties of untreated 4°C PLTs. 4°C PLT circulation, however, was unchanged by tubacin treatment, suggesting that circulation time may not be a critical factor in determining the vasculoprotective effects of PLTs. Assessing the factor content of stored PLTs revealed that angiopoietin-1 (Ang-1) increased in 4°C PLTs over time, which was further enhanced by tubacin treatment. In addition, angiopoietin-2, an inducer of vascular leak and antagonist of Ang-1, inhibited PLT barrier protection, suggesting involvement of the Tie-2 pathway. This study demonstrates that HDAC-6 inhibition with tubacin attenuates the diminished vasculo-protective properties of 4°C PLTs, and these properties may be independent of PLT circulation time.
Grace-AKO: a novel and stable knockoff filter for variable selection incorporating gene network structures
Authors: Tian Peixin , Hu Yiqian , Liu Zhonghua , Zhang Yan Dora 
Published: November 2022

AbstractMotivationVariable selection is a common statistical approach to identifying genes associated with clinical outcomes of scientific interest. There are thousands of genes in genomic studies, while only a limited number of individual samples are available. Therefore, it is important to develop a method to identify genes associated with outcomes of interest that can control finite-sample false discovery rate (FDR) in high-dimensional data settings.ResultsThis article proposes a novel method named Grace-AKO for graph-constrained estimation (Grace), which incorporates aggregation of multiple knockoffs (AKO) with the network-constrained penalty. Grace-AKO can control FDR in finite-sample settings and improve model stability simultaneously. Simulation studies show that Grace-AKO has better performance in finite-sample FDR control than the original Grace model. We apply Grace-AKO to the prostate cancer data in The Cancer Genome Atlas program by incorporating prostate-specific antigen (PSA) pathways in the Kyoto Encyclopedia of Genes and Genomes as the prior information. Grace-AKO finally identifies 47 candidate genes associated with PSA level, and more than 75% of the detected genes can be validated.
The role of subjective cognitive complaints in self-management among haemodialysis patients: a cross-sectional study
Authors: Chan Frederick H. F. , Newman Stanton , Khan Behram A. , Griva Konstadina 
Published: November 2022

Abstract
Background
Subjective cognitive complaints refer to self-experienced difficulties with everyday cognitive tasks. Although there has been a fair amount of research on cognitive impairments and cognitive complaints in end-stage renal disease, the practical implications of these complaints remain unclear. The current study aims to examine the associations of cognitive complaints with sociodemographic and clinical variables, mood, as well as key patient-reported outcomes, i.e., self-efficacy, self-management skills, and treatment adherence.

Methods
A total of 305 haemodialysis patients (mean age = 53.97 years, 42.6% female) completed the Kidney Disease Quality of Life Cognitive Function subscale, a brief measure of cognitive complaints. The recommended cut-off point of 60 was used to identify probable cognitive impairment. Measures of self-efficacy, self-management skills (i.e., symptom coping, health monitoring, health service navigation), treatment adherence, and mood symptoms were also administered. Between-group comparisons and correlational analyses were performed to examine associations of cognitive complaints with sociodemographic, clinical, and health behaviour variables. Mediation analyses were also conducted to investigate the mediating role of self-efficacy on the relationship between cognitive complaints and treatment adherence.

Results
Nearly a quarter (23.0%) of haemodialysis patients reported cognitive complaints indicative of clinical impairments. Risk of probable impairments was higher for patients with hypertension, diabetes, those diagnosed with end-stage renal disease at an older age, and those with shorter time on dialysis. Subjective cognitive complaints (both rates of probable impairments as per cut-off and continuous scores) were significantly associated with lower disease and treatment self-efficacy, poorer self-management skills, lower treatment adherence, as well as higher symptoms of distress. Mediation analysis indicated that treatment self-efficacy mediated the relationship between cognitive complaints and treatment adherence.

Conclusions
The current study demonstrated the clinical characteristics of haemodialysis patients who report cognitive complaints indicative of probable cognitive impairments and showed the associations of these complaints with self-management outcomes. Future studies should adopt more comprehensive measures of cognitive complaints and longitudinal designs to confirm the current findings.
Autoimmune encephalitis after BBIBP-CorV (Sinopharm) COVID-19 vaccination: a case report
Authors: Vences Miguel A. , Araujo-Chumacero Mary M. , Cardenas Edu , Canales Diego , Alvarez Arturo , Barja Ebelin , Albujar Maria Fe , Urrunaga-Pastor Diego 
Published: November 2022

Abstract
Background
Vaccination is an important public health strategy; however, many neurological adverse effects are associated with COVID-19 vaccination, being encephalitis a rare manifestation.

Case presentation
We present the case of a 33-year-old woman who received the first dose of the BBIBP-CorV vaccine against COVID-19 on April 4 and the second dose on April 28, 2021. Three days after receiving the second dose, she experienced a subacute episode of headache, fever, insomnia, and transient episodes of environment disconnection. We obtained negative results for infectious, systemic, and oncological causes. Brain magnetic resonance imaging showed lesions in the bilateral caudate nucleus and nonspecific demyelinating lesions at the supratentorial and infratentorial compartments. The results of the neuronal autoantibodies panel were negative. She had an adequate response to immunoglobulin and methylprednisolone; however, she experienced an early clinical relapse and received a new cycle of immunosuppressive treatment followed by a satisfactory clinical evolution.

Conclusions
We report the first case of severe encephalitis associated with BBIBP-CorV (Sinopharm) vaccination in Latin America. The patient had atypical imaging patterns, with early clinical relapse and a favorable response to corticosteroid therapy.
Formation and evolution of idiopathic lamellar macular hole-a pilot study
Authors: Lee Cheng-Yung , Hsia Yun , Yang Chung-May 
Published: November 2022

AbstractBackgroundThe developmental pathways and subsequent evolutional processes of idiopathic lamellar macular hole (LMH) were studied with spectrum domain optical coherence tomography (SD-OCT).MethodsTwenty-seven eyes of 26 patients of idiopathic LMH with pre-LMH SD-OCT available were retrospectively reviewed. Relevant OCT parameters and best-corrected visual acuity (BCVA) were collected and analyzed.ResultsFour types of developmental pathways of idiopathic LMH were noted. Type 1 (5 cases), involved disruption of a foveal cyst from vitreomacular traction. Type 2 (10 cases), demonstrated rupture of parafoveal cysts or schisis mainly from epiretinal membrane (ERM). In type 3 pathway (5 cases), a central intraretinal cyst formed under tight ERM with subsequent cyst roof dehiscence. Type 4 (7 cases), showed gradual loss of foveal tissue without cystic lesions from ERM traction. There was no statistically significant change in BCVA during LMH formations or subsequent evolutional processes in any types of the developmental pathways. Three cases developed epiretinal proliferation (EP) during evolution, which showed tendency of decrease in BCVA. Among the three cases, one later developed the degenerative configuration.ConclusionsIn summary, four types of tractional developmental pathways of idiopathic LMH were identified. BCVA was relatively stable during LMH formation and follow-up. Deterioration of visual acuity were found in cases that developed EP during evolution. Transformation into degenerative configuration might be possible after LMH formation.
Effect of the rho-kinase inhibitor ripasudil in needling with mitomycin C for the failure of filtering bleb after trabeculectomy: a cross-sectional study
Authors: Mizuno Yu , Okada Naoki , Onoe Hiromitsu , Tokumo Kana , Okumichi Hideaki , Hirooka Kazuyuki , Kiuchi Yoshiaki 
Published: November 2022

Abstract
Background
Rho-kinase inhibitors can inhibit fibrosis after glaucoma surgery. This study aimed to evaluate the effect of rho-kinase inhibitor after needling procedure with mitomycin C for the failure of filtering bleb with trabeculectomy.

Methods
This retrospective single-center study examined the effects of rho-kinase inhibitor after the needling procedure. We included 27 eyes of 27 patients with glaucoma who underwent needling procedure using mitomycin C and were subsequently treated with ripasudil—a rho-associated protein kinase inhibitor (ripasudil group)—or without ripasudil (control group). The ripasudil and control groups were compared in terms of intraocular pressure (IOP) and the number of antiglaucoma medications. Success at 12 months after the needling procedure was defined as a > 20% decrease in IOP from the preoperative period without surgical reintervention.

Results
At 12 months after the needling procedure, the mean IOP decreased from 16.9 ± 4.5 to 12.6 ± 1.1 mmHg in the control group and from 16.0 ± 5.3 to 12.2 ± 1.2 mmHg in the ripasudil group (p = 0.77). The 12-month success rates were 60.00% and 56.25% in the control and ripasudil groups (p = 0.98), respectively. In the preoperative period, the numbers of antiglaucoma drugs were 0.27 ± 0.46 and 0.92 ± 0.91 in the control and ripasudil groups (p = 0.022), respectively, and at 12 months after the needling procedure, they were 1.07 ± 1.44 and 0.73 ± 1.10 (p = 0.52), respectively.

Conclusions
Treatment with ripasudil (a rho-associated protein kinase inhibitor) after the needling procedure with mitomycin C did not show better results than treatment with the mitomycin C needling procedure alone at 12 months after the procedure.