bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Agreement among Syringing, Dacryocystography, and Dacryoendoscopy in Lacrimal Duct Obstruction
Authors: Nakamura Jutaro , Kamao Tomoyuki , Mitani Arisa , Mizuki Nobuhisa , Shiraishi Atsushi 
Published: August 2022

Abstract

Purpose: To retrospectively investigate the agreement of diagnostic findings in syringing, dacryocystography (DCG), and dacryoendoscopy in the obstruction of the lacrimal drainage system (LDS).Design: Retrospective, analytical observational studyMethods: We examined 113 patients (211 LDS) who underwent syringing, DCG, and dacryoendoscopy to preoperatively evaluate LDS obstruction. Obstruction was compared by classifying the obstruction grade and site into three levels, respectively. The diagnostic agreement between tests was assessed by determining the weighted kappa value.Results: A total of 25 male (49 LDS) and 88 female patients (162 LDS) were included in this study. Obstruction was observed in 77.4%, 60.0%, and 81.3% of LDS by syringing, DCG, and dacryoendoscopy, respectively. Regarding the agreement in obstruction grade, Cohen’s kappa value for DCG and dacryoendoscopy was 0.65 (95% confidence interval [CI]: 0.56–0.74). DCG found no obstruction in 38.4% of all LDS, whereas 47.9% of them showed stenosis or obstruction by dacryoendoscopy. Meanwhile, DCG and dacryoendoscopy showed consistency in the obstruction site in 77.9% of LDS. When discrepancies were observed between syringing and dacryoendoscopy to detect the obstruction site, the combination of syringing and DCG reached dacryoendoscopy findings at the 99% level.Conclusions: “Substantial” agreements were found in the diagnostic findings among the three examinations. Then, the highest agreement was observed between syringing and dacryoendoscopy in determining the obstruction site. The lowest agreements were observed between syringing and DCG in diagnosing the obstruction grade and site.
Clinical and MRI analyses of dorsal spinal column function in compressive cervical myelopathy
Authors: Mizouchi Tatsuki , Urakawa Takaaki , Watanabe Kei , Matsuzawa Hitoshi , Yoshimura Norihiko , Inagawa Shoichi , Kanazawa Tsutomu , Saito Hiroaki , Kimura Shinji , Endo Naoto 
Published: August 2022

Abstract
This study aimed to evaluate whether the somatosensory functions of the upper (UE) and lower extremities (LE) were correlated with the degree of fasciculus cuneatus (FC) and fasciculus gracilis (FG) degeneration based on magnetic resonance imaging in patients with compressive cervical myelopathy (CCM). We prospectively recruited 32 patients with CCM. Median nerve somatosensory evoked potentials (SEPs) and the Semmes–Weinstein monofilament (SWM) test were employed to test UE somatosensory function. Tibial nerve SEPs, the foot SWM test, and Romberg ratio were used to evaluate LE somatosensory function. We imaged FC and FG using three-dimensional anisotropy contrast diffusion magnetic resonance axonography. Diffusion tensor invariant of fractional anisotropy (FA) was used to measure the degree of degeneration in FC and FG. FA values of FC degeneration were significantly correlated with the median nerve SEPs (Spearman’s rank correlation coefficient [rs] = − 0.66) and hand SWM tests (rs = − 0.52). FA values of FG degeneration were correlated with the tibial nerve SEPs (rs = − 0.66), foot SWM tests (rs = − 0.70), and Romberg ratio (rs = − 0.60). Our study demonstrates that in patients with CCM, UE and LE somatosensory examinations are correlated with the degree of degeneration in the FC and FG, respectively.
Developing A Central Analytic Repository To Improve Decision Making By Stakeholders
Authors: Asangansi Ime , Meribole Emmanuel , Adoghe Anthony , Ajaka Chiamaka , Noiki Ifeoluwa , Shiishi-Gyer Doosuur , Sanni Abdulqudus 
Published: August 2022

Abstract

BackgroundThe rise in data analytics has resulted in the need for data to be pooled into centralized large-scale repositories to support more organized analytics. In the health sector, housing health data in a central analytic repository makes it easier for policymakers to access and make faster, more efficient informed decisions that impact the population, especially in cases of emergencies and disease outbreaks. Our study aimed to develop a centralized health data analytics repository for Nigeria called the Multi-Source Data Analytics and Triangulation (MSDAT) platform to improve decision-making by stakeholders.MethodsThe MSDAT design and development was a data and user-centred process guided and informed by the perspectives and requirements of analysts and stakeholders from the Federal Ministry of Health, Nigeria. The inclusion of health indicators and data sources on the platform was based on: (1) national relevance (2) global health interest (3) availability of datasets and (4) specific requests from stakeholders. The first version of the platform was developed and iteratively revised based on stakeholder feedback.ResultsWe developed the MSDAT for the purpose of consolidating health-related data from various data sources. It has 4 interactive sections for; (1) indicator comparison across routine and non-routine data sources (2) indicator comparison across states and local government areas (3) geopolitical zonal analysis of indicators (4) multi-indicator comparisons across states.ConclusionThe MSDAT is a revolutionary platform essential to the improvement of health data quality. By transparently visualizing data and trends across multiple sources, data quality and use are brought to focus to reduce variations between different data sources over time and improve the overall understanding of key trends and progress within the health sector. Hence, the platform should be fully adopted and utilized at all levels of governance. It should also be expanded to accommodate other data sources and indicators that cut across all health system areas.
Current femoral stem fixation in hip arthroplasty for hip fractures after the revised national guidelines in Japan: a questionnaire survey in a super-aging prefectural area
Authors: Miura Takanori , Kijima Hiroaki , Tazawa Hiroshi , Miyakoshi Naohisa 
Published: August 2022

Abstract
BackgroundThe Japanese guidelines for the management of hip fractures were most recently revised in 2021 to recommend the use of cemented stems in cases of bone fragility. However, the selection of cementless or cemented stem fixations remains controversial. This study aimed to examine the current stem selection strategy in bipolar hemiarthroplasty, concerns about using cemented stems, and factors affecting the ability to instruct cemented stems.MethodsThis study included 94 orthopedic surgeons from 27 facilities who answered a web-based questionnaire survey of 15 questions in the super-aging prefectural area in Japan from January to February 2022. Multiple logistic regression analysis was used to identify the factors associated with the ability to instruct the cemented stem. The cutoff value for the number of cemented stem usage experiences that can be used to instruct cemented stems was determined using the receiver operating characteristic (ROC) curve.ResultsA total of 97.8% of doctors answered that the cementless stem was the current first choice, and 83.0% of doctors had only 0–10 cases of the cemented stem. Meanwhile, only 14.9% of doctors are expected to increase the use of cemented stems in the future. The cement technique was the greatest concern regarding the use of cement stems (60.6%). On multivariate analysis, the number of surgeries of the cemented stem was the factor most affecting the ability to instruct the cemented stem (odds ratio: 8.42, p=0.001). In the ROC curve analysis for the capability of instructing cemented stems and the number of surgeries using cemented stems, the best cutoff value was 1–10 cases (sensitivity, 94.4%; specificity, 58.6%), with an area under the curve of 0.8448 (95% confidence interval: 0.7754–0.9142). When the cut-off value was 11–50 cases, the specificity was higher (sensitivity, 41.7%; specificity, 98.3%).ConclusionsA few doctors still select cemented stems as the first choice. The number of surgeries on the cemented stem was the factor most affecting the ability to instruct the cemented stem, and more than 11 cases are desirable.
Health-Related Quality of Life scores among low-income patients on Social Welfare Programs in Japan: A repeated cross-sectional study
Authors: Wakata Satoshi , Nishioka Daisuke , Takaki Yukio 
Published: August 2022

Abstract
Background: Low-income is one of the well-established determinants of people’s health and health-related behavior including susceptibility to coronavirus disease 2019 (COVID-19) infection. To support financial access to medical care among low-income patients, there are two social welfare services in Japan: Public Assistance (PA) which provide both minimum income and medical costs, and Free/Low-Cost Medical Care (FLCMC) in which only medical costs were covered. The purpose of this study was to describe and compare the changes in Health-Related Quality of Life (HRQOL) scores before and after the COVID-19 pandemic among low-income patients on PA, FLCMC, and the general population, to examine if the social welfare services contributed to protect low-income people’s HRQOL during the pandemic.Methods: We used repeated cross-sectional data obtained from adult patients on FLCMC or PA and those without social welfare services who regularly visit the Kamigyo clinic in Kyoto, Japan. We collected the data from 2018 and 2021 using a questionnaire about patients’ socioeconomic attributes and Medical Outcomes Study 12-Item Short Form Health Survey (SF-12).Results: We analyzed data of 200 individuals in 2018 and 174 individuals in 2021. Low-income patients on social welfare services had lower physical health component summary (PCS) score, and the role-social component summary (RCS) score than general population in each year. The results of multiple linear regression analyses with robust standard estimator showed that the decline in Mental Component Summary (MCS) score was significantly larger among FLCMC recipients than patients without welfare services (coefficient: -4.71, 95% Confidence Interval: -8.92 to -0.51), while the decline in MCS scores among PA recipients were not significant when compared to the general population.Conclusions: Low-income patients on social welfare services especially on FLCMC experienced the significant decline in MCS scores during COVID-19 pandemic. To maintain mental health of low-income patients on social welfare services in the pandemic, need to be provided with not only social care, but financial livelihood support may also be required.Trial registration: N/A
Delphi Study to Develop Training Materials to Detect Maternal Mental Disorder for Health Cadres
Authors: Surjaningrum Endang Retno , Leonardi Tino , Mujahadah Husnul 
Published: August 2022

Abstract

Background: This study aims to obtain themes and constructs to develop modules and training curricula for posyandu cadres for the detection of mental disorders in pregnant and breastfeeding mothers in Surabaya, Indonesia. Method: The Delphi method through three stages was applied: (1) searching for academic and non-academic references, (2) compiling themes and constructs based on the findings of the first phase and distributing them to expert panel, and (3) concluding a consensus according to the guidelines. Results: The panel approved two training objectives, five training materials, six training methods, two training time, two training duration, two training evaluation method, and six trainer qualifications. Conclusions: The findings can be the basis for developing modules and curricula to detect mental disorders in pregnant and breastfeeding women for cadres in Indonesia.
Constructing high-density tissue microarrays with a novel method and a self-made tissue-arraying instrument
Authors: Qin Ping , Zhao Li , Bian Piaopiao , Xiong Zhongtang 
Published: August 2022

Abstract
Tissue microarrays (TMAs), also called tissue chips, contain hundreds to thousands of tissue cores obtained from different tissue donor blocks. By using TMA technology, a molecular marker, such as protein, RAN or DNA, can be simultaneously examined in hundreds of different specimens under the same experimental conditions. A growing number of previous studies have introduced different methods for constructing TMAs. Many authors tried to use various methods to implant more tissue cores in a single recipient block, and most of these methods involved reducing the diameter of the tissue cores and/or the spacing between adjacent tissue cores. However, when creating TMAs, it is difficult to reduce the distance between tissue cores to zero except with extremely expensive automatic TMA arrayers. Here, we introduce a novel method to construct a high-density TMA that does not have spacing between the tissue cores. We also introduce a method for preparing a self-made tissue‑arraying instrument. With this method and the tissue‑arraying instrument, we successfully created a TMA containing 126 tissue cores that were 2 mm in diameter. H&E staining, immunohistochemical staining and fluorescence in situ hybridization were performed on the sections cut from the TMA without any tissue spot loss. This method is easy to operate, and the materials for creating the tissue‑arraying instrument are inexpensive and can be purchased anywhere. Therefore, this high-density method can be applied in all laboratories.
Mapping Effective Connectivity of Human Amygdala Subdivisions with Intracranial Stimulation
Authors: Sawada Masahiro , Adolphs Ralph , Dlouhy Brian , Jenison Rick , Rhone Ariane , Kovach Christopher , Greenlee Jeremy , Howard Matthew , Oya Hiroyuki 
Published: August 2022

Abstract
The primate amygdala is a complex consisting of over a dozen nuclei, each with distinct connectivity patterns that have been implicated in a host of cognitive functions, individual differences, and psychiatric illnesses. The most robust functional distinction in humans is between medial and lateral nuclei, but connectivity profiles of these subdivisions are based primarily on correlations observed in blood oxygenation-level dependent functional MRI (BOLD-fMRI), limiting spatiotemporal resolution and causal conclusions. Here we conducted concurrent focal bipolar electrical stimulation through depth electrodes with intracranial electroencephalography (electrical stimulation tract-tracing; es-TT), and with fMRI (electrical stimulation fMRI; es-fMRI) in 25 neurosurgical patients (13 es-TT, 16 es-fMRI).

es-TT (51 sessions recorded over 3000 intracranial electrodes) produced profiles of effective connectivity with characteristic latencies of 15 ms (N/P15) and 150 ms (P150) that distinguished medial from lateral amygdala. Whereas lateral stimulation induced greater N/P15 potentials in anterior cingulate, sensorimotor cortex, superior temporal sulcus (STS) and superior parietal lobe (SPL), medial amygdala stimulation produced greater N150 responses in orbitofrontal cortex (OFC), superior temporal gyrus (STG), middle temporal gyrus (MTG) and prefrontal cortex (PFC). es-fMRI confirmed a similar spatial segregation of responses. Orbitofrontal cortex and anterior cingulate cortex were the key components of an amygdala network and received rapid signal propagation from the amygdala, which then continued to PFC and lateral temporal lobe, before reaching to sensorimotor and parietal cortices. Second-order effects of stimulation engaged network over broad areas of cortex, further distinguishing the site of amygdala stimulation. The findings provide a uniquely detailed characterization of human amygdala functional connectivity that will inform functional neuroimaging studies in healthy and clinical populations.
Factors Influencing the Students’ Perception of Lecturing Skills in Saudi Dental Schools
Authors: Al Kuwaiti Ahmed 
Published: August 2022

Introduction:
Students' feedback is vital in improving the teaching and learning process in dental schools across the globe, including Saudi Arabia.

Objective:
This study explores the factors influencing the students' perception of faculty members' lecturing skills in Saudi dental schools. It also determines whether there is any gender difference in their perception of lecturing skills.

Methods:
The exploratory study design was utilized to evaluate the factors influencing the dental students' perception of lecturing skills at the selected Saudi dental schools (n=4). This study included the complete student population (n=530) of the undergraduate dental program at those schools during the academic year 2020-2021. A questionnaire titled “Students Survey of Lecturing Skills (SSLS)” was distributed to the students through an online tool. The data of the completed questionnaires (n=426) was subjected to statistical analysis using statistical software.

Results:
The structural equation modeling (SEM) analysis revealed that five factors of SSLS, namely, Organization and Structure of the lectures (OS)”, “Lectures Effectiveness on Learning and Understanding (LEL)”, “Interest and Motivation (IM)”, “Professional Interaction (PI)”, and “Presentation and Classroom Atmosphere (PC)” are vital to evaluate the dental students' perception towards lecturing skills. Also, these five factors have significantly influenced the students' perception of faculty members' lecturing skills in Saudi dental schools. Overall, female dental students are highly satisfied than the male students in regard to their faculty members' lecturing skills.

Conclusion:
OS, LEL, IM, PI, and PC are the significant factors influencing dental students' perception of lecturing skills. These factors can be considered while assessing teaching quality and framing effective strategies for enhancing it at Saudi dental schools.
The Influence of Provaping “Gatewatchers” on the Dissemination of COVID-19 Misinformation on Twitter: Analysis of Twitter Discourse Regarding Nicotine and the COVID-19 Pandemic
Authors: Silver Nathan , Kierstead Elexis , Kostygina Ganna , Tran Hy , Briggs Jodie , Emery Sherry , Schillo Barbara 
Published: August 2022

Background
There is a lot of misinformation about a potential protective role of nicotine against COVID-19 spread on Twitter despite significant evidence to the contrary. We need to examine the role of vape advocates in the dissemination of such information through the lens of the gatewatching framework, which posits that top users can amplify and exert a disproportionate influence over the dissemination of certain content through curating, sharing, or, in the case of Twitter, retweeting it, serving more as a vector for misinformation rather than the source.

Objective
This research examines the Twitter discourse at the intersection of COVID-19 and tobacco (1) to identify the extent to which the most outspoken contributors to this conversation self-identify as vaping advocates and (2) to understand how and to what extent these vape advocates serve as gatewatchers through disseminating content about a therapeutic role of tobacco, nicotine, or vaping against COVID-19.

Methods
Tweets about tobacco, nicotine, or vaping and COVID-19 (N=1,420,271) posted during the first 9 months of the pandemic (January-September 2020) were identified from within a larger corpus of tobacco-related tweets using validated keyword filters. The top posters (ie, tweeters and retweeters) were identified and characterized, along with the most shared Uniform Resource Locators (URLs), most used hashtags, and the 1000 most retweeted posts. Finally, we examined the role of both top users and vape advocates in retweeting the most retweeted posts about the therapeutic role of nicotine, tobacco, or vaping against COVID-19.

Results
Vape advocates comprised between 49.7% (n=81) of top 163 and 88% (n=22) of top 25 users discussing COVID-19 and tobacco on Twitter. Content about the ability of tobacco, nicotine, or vaping to treat or prevent COVID-19 was disseminated broadly, accounting for 22.5% (n=57) of the most shared URLs and 10% (n=107) of the most retweeted tweets. Finally, among top users, retweets comprised an average of 78.6% of the posts from vape advocates compared to 53.1% from others (z=3.34, P<.001). Vape advocates were also more likely to retweet the top tweeted posts about a therapeutic role of nicotine, with 63% (n=51) of vape advocates retweeting at least 1 post compared to 40.3% (n=29) of other top users (z=2.80, P=.01).

Conclusions
Provaping users dominated discussions of tobacco use during the COVID-19 pandemic on Twitter and were instrumental in disseminating the most retweeted posts about a potential therapeutic role of tobacco use against the virus. Subsequent research is needed to better understand the extent of this influence and how to mitigate the influence of vape advocates over the broader narrative of tobacco regulation on Twitter.
TARGET – Real-World-Evidence study on the long-term benefits of MCT ® -associated pollen allergoid SCIT on AR and asthma
Authors: Kruppert Silvia , C Vogelberg , Klimek Ludger , Becker Sven 
Published: August 2022

Background: Allergen immunotherapy (AIT) may have a long-term disease
modifying effect. The aim of this study is to demonstrate the long-term
benefit of MCT®-associated allergoid pollen SCIT (MCT®-associated -AIT)
on allergic rhinitis (AR) and asthma in clinical practice. Methods: In
this retrospective Real-World-Evidence (RWE) study the impact of AIT on
the progression of AR and onset of need for asthma medication was
analyzed using a German longitudinal database. Anonymized prescription
data of AR patients and exactly matched control patients aged from 5-65
years were analyzed. Results: Significantly less patients treated with
MCT®-associated-AIT did receive prescriptions for symptomatic AR
medication in the follow up period vs. control group (OR: 0.27;
p < 0.001). Further, significantly less asthmatic patients
under MCT®-associated-AIT did receive prescriptions for asthma
medications (OR: 0.48; p = 0.004). In addition, the prescriptions of AR
and asthma medication for MCT®-associated-AIT patients were
significantly reduced in the follow-up vs. baseline and control group
(24.2% and 35.6%, respectively, p < 0.001).The probability
of asthma medication onset in non-asthmatic patients during follow-up
was significantly reduced for AIT patients compared to controls (OR:
0.77, p = 0.001). All endpoints were significant for
children/adolescents and adults in the individual analyses. Conclusions:
This study gives evidence for long-term benefits up to 9.5 years of
MCT®-associated-AIT on the need for AR and new-onset asthma medication
in AR patients and asthma medication in asthmatics in an RWE setting.