bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness and safety of ibuprofen and acetylsalicylic acid in acute rheumatic fever
Authors: Yılmaz Münevver , Gürses Dolunay , Tükenmez Gizem 
Published: January 2022

AbstractBackgroundAcetylsalicylic acid (ASA) is a non‐steroidal anti‐inflammatory drug used in the treatment of acute rheumatic fever (ARF) and it can cause serious adverse effects. This study aimed to evaluate the clinical efficacy and side effects of ibuprofen in the treatment of ARF compared to the classic treatment, ASA.MethodsChildren who were hospitalized for the treatment of ARF with isolated arthritis and mild carditis between October 2015 and October 2018 and who received non‐steroidal anti‐inflammatory therapy were evaluated in the study. We compared the demographic data, clinical findings, efficacy, and side effects of the treatments of the children, who were divided into ASA and ibuprofen groups.ResultsOf the 38 patients included in the study, 21 were treated with ASA (ASA group), and 17 were given ibuprofen (IBU group). There was no difference between the groups regarding the length of hospital stay, total treatment time, time to resolution of clinical symptoms, and normalization of acute‐phase reactants. Liver enzymes increased during treatment in 13 patients (62%) in the ASA group and three patients (18%) in the IBU group (P = 0.009). In the ASA group, 69% of patients with increased liver enzymes were under 11 years of age during treatment. Clinical side effects were observed in three patients in the ASA group while none were observed in the IBU group.ConclusionThe results of this study suggest that ibuprofen can be a safe alternative in the treatment of ARF, especially in young children. Although ibuprofen can be a safe and effective alternative to ASA, studies including larger series are needed on this subject.
Improved Spectral Purity of 222‐nm Irradiation Eliminates Detectable Cyclobutylpyrimidine Dimers Formation in Skin Reconstructs even at High and Repetitive Disinfecting Doses
Authors: Ivanova Irina , Svilenska Teodora , Kurz Bernadett , Grobecker Sonja , Maisch Tim , Berneburg Mark , Kamenisch York 
Published: January 2022

AbstractUVC222 nm has germicidal effects with potential clinical applications. However, UVC irradiation is capable of inducing DNA damage like cyclobutylpyrimidine dimers (CPD). Although new devices have emission peaks in the short‐wavelength region of UVC (~222 nm), the remaining “collateral” radiation at longer wavelengths could be harmful to human health. We investigated the DNA damage caused by far‐UVC 222 nm KrCl exciplex radiation on human skin reconstructs after additional filtering using silica filters. The skin reconstructs were irradiated with 100 mJ cm−2, 500 mJ cm−2, and 3 × 500 mJ cm−2 unfiltered and filtered (230–270 nm suppressed) far‐UVC or UVB (308 nm) radiation. UVB and non‐filtered UVC irradiation induced a significant amount of CPDs, compared with the background. Filtered far‐UVC lowered the CPD amount compared with unfiltered UVC and UVB treatments. Repetitive UVC irradiation did not result in the accumulation of CPDs compared with UVB treatment. Reduction in excess of 99.9% of E. coli, S. aureus and C. albicans was detected after applying far‐UVC radiation. This identifies a therapeutic window in which microorganisms are killed but tissue is still alive and not damaged, which could give rise to new clinical applications.
The Intersectionality of Deservingness for State Support
Authors: Assouline Michaela , Gilad Sharon 
Published: January 2022

AbstractStudies of the ramifications of client race and ethnicity for bureaucrats' judgments treat minority status as homogenous. Yet, individual identity does not boil down to race or ethnicity. Members of racial and ethnic minority groups likely vary in their experiences and capacity to overcome the negative sentiments and stereotypes that burden their inherited group. To transcend unidimensional explanations, we combine Van Oorschot's deservingness framework and a gendered lens to study how the intersection of group identity and gender, as well as individuals' work history, co‐shape bureaucrats' categorization of clients. Empirically, we analyze Israeli professionals' categorization of applicants for state benefits, comparing their assessments of men and women of three social groups: the Jewish majority, ultra‐orthodox Jews, and Muslims. Interpreting the empirical findings, we offer that underlying the effect of applicants' group demographics are perceived cultural affinity to the majority and social contributions that vary with gender.Evidence for Practice

Minority status, based on race, ethnicity, or nationality, and the perceived contributions of different groups, shape bureaucrats' judgments of individuals' deservingness for state support.
Minorities' workforce opportunities and interactions with members of the majority likely vary with gender roles.
If traditional gender roles among some minority communities provide men with greater opportunities for workforce participation and for interaction with members of the majority, bureaucrats may perceive women as less deserving than men. Depending on the task at hand, this could hamper women's likelihood of attaining benefits for which they are entitled.
COVID‐19 infection and the broader impacts of the pandemic on healthcare workers
Authors: Smallwood Natasha , Harrex Warren , Rees Megan , Willis Karen , Bennett Catherine M. 
Published: January 2022

AbstractThe severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) disease or COVID‐19 pandemic is associated with more than 230 million cases and has challenged healthcare systems globally. Many healthcare workers (HCWs) have acquired the infection, often through their workplace, with a significant number dying. The epidemiology of COVID‐19 infection in HCWs continues to be explored, with manifold exposure risks identified, leading to COVID‐19 being recognised as an occupational disease for HCWs. The physical illness due to COVID‐19 in HCWs is similar to the general population, with some HCWs experiencing a long‐term illness, which may impact their ability to return to work. HCWs have also been affected by the immense workplace and psychosocial disruption caused by the pandemic. The impacts on the psychological well‐being of HCWs globally have been profound, with high prevalence estimates for mental health symptoms, including emotional exhaustion. Globally, governments, healthcare organisations and employers have key responsibilities, including: to be better prepared for crises with comprehensive disaster response management plans, and to protect and preserve the health workforce from the physical and psychological impacts of the pandemic. While prioritising HCWs in vaccine rollouts globally has been critical, managing exposures and outbreaks occurring in healthcare settings remains challenging and continues to lead to substantial disruption to the health workforce. Safeguarding healthcare workforces during crises is critical as we move forward on the new path of ‘COVID normal’.
Description of a low‐cost picture archiving and communication system based on network‐attached storage
Authors: Costanza Dario , Coluccia Pierpaolo , Castiello Erica , Greco Adelaide , Meomartino Leonardo 
Published: January 2022

AbstractHigh costs for installing, maintaining, and updating a standard picture archiving and communication system (PACS) can be prohibitive for small/medium‐sized veterinary facilities. The aims of this prospective, exploratory study were to describe the design, implementation, and author experiences for 1 year's use of a low‐cost PACS based on network‐attached storage. The system described here was easily installed and resiliently stored redundant copies of data. It excellently balanced data recovery, system speed, security, and available memory for storage. A virtual private network also allowed off‐site data review. This system can also be used for future off‐site backup of data in the cloud.
COVID-19 Pandemic and Individuals With Intellectual Disability: Special Olympics as an Example of Organizational Responses and Challenges
Authors: Temple Viviene A. 
Published: January 2022

The COVID-19 pandemic is a worldwide crisis. It has been, and is, an extreme challenge for our health care and prevention systems, and for society as a whole. Among many facets of life, physical activity and sport has been heavily impacted. The aim of this viewpoint article is to highlight the effect of the COVID-19 pandemic on individuals with an intellectual disability, with a particular focus on physical activity and Special Olympics. Specific objectives are (a) to share what the literature reveals about the impact of COVID-19 on the health and well-being of individuals with an intellectual disability, (b) to examine what is known about the impact of the pandemic on physical activity of individuals with an intellectual disability, (c) to describe Special Olympics program responses during the pandemic, and (d) to recommend areas for future research.
Aqueous Level of ANGPTL4 Correlates with the OCTA Metrics of Diabetic Macular Edema in NPDR
Authors: Xu Qing , Gong Chaoju , Qiao Lei , Feng Ruifang , Liu Haiyang , Liu Yalu , Ji Sujuan , Zhang Yipeng , Wu Shuang , Li Suyan 
Published: January 2022

Purpose. To investigate the aqueous levels of angiogenic factors in nonproliferative diabetic retinopathy (NPDR) patients with diabetic macular edema (DME) and to ascertain their association with optical coherence tomography angiography (OCTA) metrics. Methods. This study enrolled 21 NPDR eyes with DME (NPDR/DME+), 17 NPDR eyes without DME (NPDR/DME-), and 16 diabetic eyes without retinopathy (DWR). Luminex bead-based multiplex array was used to measure the levels of 25 cytokines. OCTA system with a scan area of

3
×
3

mm

was used to measure retinal thickness (RT), retinal volume (RV), superficial vessel density (SVD), deep vessel density (DVD), foveal avascular zone (FAZ) area, perimeter and acircularity index. Results. The levels of ANGPTL4 were significantly different among the three groups (

P
<
0.05

), in which NPDR/DME+ group had the highest level and NPDR/DME- group had a higher level than the DWR group (all,

P
<
0.0167

). OCTA examination showed that, compared with DWR and NPDR/DME- group, RT and RV increased and the whole/parafoveal DVD decreased in NPDR/DME+ group (all,

P
<
0.05

). Meanwhile, NPDR/DME- group had lower parafoveal DVD than the DWR group (

P
<
0.05

). Correlation analysis showed that the levels of ANGPTL4 were positively correlated with foveal/parafoveal RT and RV and negatively correlated with whole/parafoveal DVD in NPDR patients (all,

P
<
0.05

). As the influencing factor of RT, RV, and DVD, every additional 103 pg/ml of ANGPTL4 was associated with an increase in foveal and parafoveal RT of 4.299 μm and 3.598 μm, respectively. Every additional 106 pg/ml of ANGPTL4 was associated with an increase in foveal and parafoveal RV of 3.371 mm3 and 17.705 mm3, respectively. Every additional 104 pg/ml of ANGPTL4 was associated with a decrease in whole and parafoveal DVD of 1.705% and 1.799%, respectively. Conclusions. The level of ANGPTL4 in aqueous humor of NPDR patients with DME was significantly increased and ANGPTL4 might predict RT, RV, and parafoveal DVD of DME in NPDR patients.
The Pellino1–PKCθ Signaling Axis Is an Essential Target for Improving Antitumor CD8+ T-lymphocyte Function
Authors: Park Jihyun , Lee Si-Yeon , Jeon Yoon , Kim Kyung-Mo , Lee Jin-Kwan , Ko Jiwon , Park Eun-Ji , Yoon Joon-Sup , Kang Baeki E. , Ryu Dongryeol , Lee Ho , Shin Su-Jin , Go Heounjeong , Lee Chang-Woo 
Published: January 2022

Abstract

CD8+ T cells play an important role in the elimination of tumors. However, the underlying mechanisms involved in eliciting and maintaining effector responses in CD8+ T cells remain to be elucidated. Pellino1 (Peli1) is a receptor signal-responsive ubiquitin E3 ligase, which acts as a critical mediator for innate immunity. Here, we found that the risk of developing tumors was dependent on Peli1 expression. Peli1 was upregulated in CD8+ T cells among tumor-infiltrating lymphocytes (TIL). In contrast, a deficit of Peli1 enhanced the maintenance and effector function of CD8+ TILs. The development of Peli1-deficient CD8+ TILs prevented T-cell exhaustion and retained the hyperactivated states of T cells to eliminate tumors. We also found that Peli1 directly interacted with protein kinase C-theta (PKCθ), a central kinase in T-cell receptor downstream signal transduction, but whose role in tumor immunology remains unknown. Peli1 inhibited the PKCθ pathway by lysine 48–mediated ubiquitination degradation in CD8+ TILs. In summary, the Peli1–PKCθ signaling axis is a common inhibitory mechanism that prevents antitumor CD8+ T-cell function, and thus targeting Peli1 may be a useful therapeutic strategy for improving cytotoxic T-cell activity.
Impact of Chronic Kidney Disease on the Associations of Cardiovascular Biomarkers With Adverse Outcomes in Patients With Suspected or Known Coronary Artery Disease: The EXCEED‐J Study
Authors: Wada Hiromichi , Shinozaki Tsuyoshi , Suzuki Masahiro , Sakagami Satoru , Ajiro Yoichi , Funada Junichi , Matsuda Morihiro , Shimizu Masatoshi , Takenaka Takashi , Morita Yukiko , Yonezawa Kazuya , Matsubara Hiromi , Ono Yujiro , Nakamura Toshihiro , Fujimoto Kazuteru , Ninomiya Akiyo , Kato Toru , Unoki Takashi , Takagi Daisuke , Wada Kyohma , Wada Miyaka , Iguchi Moritake , Yamakage Hajime , Kusakabe Toru , Yasoda Akihiro , Shimatsu Akira , Kotani Kazuhiko , Satoh‐Asahara Noriko , Abe Mitsuru , Akao Masaharu , Hasegawa Koji ,   for the EXCEED‐J Study Investigators
Published: January 2022

Background
The impact of chronic kidney disease (CKD) on the prognostic utility of cardiovascular biomarkers in high‐risk patients remains unclear.

Methods and Results
We performed a multicenter, prospective cohort study of 3255 patients with suspected or known coronary artery disease (CAD) to investigate whether CKD modifies the prognostic utility of cardiovascular biomarkers. Serum levels of cardiovascular and renal biomarkers, including soluble fms‐like tyrosine kinase‐1 (sFlt‐1), N‐terminal pro‐brain natriuretic peptide (NT‐proBNP), high‐sensitivity cardiac troponin‐I (hs‐cTnI), cystatin C, and placental growth factor, were measured in 1301 CKD and 1954 patients without CKD. The urine albumin to creatinine ratio (UACR) was measured in patients with CKD. The primary outcome was 3‐point MACE (3P‐MACE) defined as a composite of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke. The secondary outcomes were all‐cause death, cardiovascular death, and 5P‐MACE defined as a composite of 3P‐MACE, heart failure hospitalization, and coronary/peripheral artery revascularization. After adjustment for clinical confounders, sFlt‐1, NT‐proBNP, and hs‐cTnI, but not other biomarkers, were significantly associated with 3P‐MACE, all‐cause death, and cardiovascular death in the entire cohort and in patients without CKD. These associations were still significant in CKD only for NT‐proBNP and hs‐cTnI. NT‐proBNP and hs‐cTnI were also significantly associated with 5P‐MACE in CKD. The UACR was not significantly associated with any outcomes in CKD. NT‐proBNP and hs‐cTnI added incremental prognostic information for all outcomes to the model with potential clinical confounders in CKD.

Conclusions
NT‐proBNP and hs‐cTnI were the most powerful prognostic biomarkers in patients with suspected or known CAD and concomitant CKD.
Computational approaches to treatment response prediction in major depression using brain activity and behavioral data: A systematic review
Authors: Karvelis Povilas , Charlton Colleen E. , Allohverdi Shona G. , Bedford Peter , Hauke Daniel J. , Diaconescu Andreea O. 
Published: January 2022

Abstract
Major depressive disorder is a heterogeneous diagnostic category with multiple available treatments. With the goal of optimizing treatment selection, researchers are developing computational models that attempt to predict treatment response based on various pretreatment measures. In this paper, we review studies that use brain activity data to predict treatment response. Our aim is to highlight and clarify important methodological differences between various studies that relate to the incorporation of domain knowledge, specifically within two approaches delineated as data-driven and theory-driven. We argue that theory-driven generative modeling, which explicitly models information processing in the brain and thus can capture disease mechanisms, is a promising emerging approach that is only beginning to be utilized in treatment response prediction. The predictors extracted via such models could improve interpretability, which is critical for clinical decision-making. We also identify several methodological limitations across the reviewed studies and provide suggestions for addressing them. Namely, we consider problems with dichotomizing treatment outcomes, the importance of investigating more than one treatment in a given study for differential treatment response predictions, the need for a patient-centered approach for defining treatment outcomes, and finally, the use of internal and external validation methods for improving model generalizability.
Optimization of the image contrast for the developing fetal brain using 3D radial VIBE sequence in 3 T magnetic resonance imaging
Authors: Liao Yi , Li Xuesheng , Jia Fenglin , Ye Zhijun , Ning Gang , Liu Sai , Li Pei , Fu Chuan , Li Qing , Wang Shaoyu , Zhang Huapeng , Qu Haibo 
Published: January 2022

Abstract
Background
Faster and motion robust magnetic resonance imaging (MRI) sequences are desirable in fetal brain MRI. T1-weighted images are essential for evaluating fetal brain development. We optimized the radial volumetric interpolated breath-hold examination (VIBE) sequence for qualitative T1-weighted images of the fetal brain with improved image contrast and reduced motion sensitivity.

Materials and methods
This was an institutional review board-approved prospective study. Thirty-five pregnant subjects underwent fetal brain scan at 3 Tesla MRI. T1-weighted images were acquired using a 3D radial VIBE sequence with flip angles of 6º, 9º, 12º, and 15º. T1-weighted images of Cartesian VIBE sequence were acquired in three of the subjects. Qualitative assessments including image quality and motion artifact severity were evaluated. The image contrast ratio between gray and white matter were measured. Interobserver reliability and intraobserver repeatability were assessed using intraclass correlation coefficient (ICC).

Results
Interobserver reliability and intraobserver repeatability universally revealed almost perfect agreement (ICC > 0.800). Significant differences in image quality were detected in basal ganglia (P = 0.023), central sulcus (P = 0.028), myelination (P = 0.007) and gray matter (P = 0.023) among radial VIBE with flip angles 6º, 9º, 12º, 15º. Image quality at the 9º flip angle in radial VIBE was generally better than flip angle of 15º. Radial VIBE sequence with 9º flip angle of gray matter was significantly different by gestational age (GA) before and after 28 weeks (P = 0.036). Quantified image contrast was significantly different among different flip angles, consistent with qualitative analysis of image quality.

Conclusions
Three-dimensional radial VIBE with 9º flip angle provides optimal, stable T1-weighted images of the fetal brain. Fetal brain structure and development can be evaluated using high-quality images obtained using this angle. However, different scanners will achieve different TRs and so the FA should be re-optimized each time a new protocol is employed.
Phenotypic diversity among juvenile polyposis syndrome patients from different ethnic background
Authors: Katz Lior Haim , Gingold-Belfer Rachel , Vainer Elez , Hegger Shani , Laish Ido , Derazne Estela , Weintraub Ilana , Reznick-Levi Gili , Goldberg Yael , Levi Zohar , Cohen Shlomi , Half Elizabeth E. 
Published: January 2022

Abstract
Juvenile polyposis syndrome (JPS), has diverse phenotypes. Aim: To assess mutation rate, clinical features and genotype-phenotype correlation among Israeli JPS kindreds from different ethnicities.

Methods
Patients’ data were extracted retrospectively from 5 centers.

Results
Thirty five kindreds (49 patients) were included. Thirty one (89%) Jewish [10 (32%) Ashkenazi; 9 (29%) Sephardi; 11 (35%) non-Russia former Soviet-Union countries (NRFSU), one (3%) unknown]. 40/49 individuals from 27 families underwent genetic testing. Among them 34, from 21 families (85, 78%, respectively) had a pathogenic mutation: BMPR1A n = 15 (71%), SMAD4 n = 6 families (29%). While no SMAD4 mutation was described among Jewish families from NRFSU, 7 NRFSU families carried a founder mutation comprising a large genomic deletion of BMPR1A. GI involvement was reported in 42 patients (86%): colonic polyps (n = 40, 95%, > 50 polyps n = 14, 35%) and 12 underwent colonic resection. Fourteen patients (34%) had gastric or small bowel involvement (n = 5) and 4\14 underwent gastrectomy due to polyp burden. Families from NRFSU had more gastric involvement (66.7% vs. 22.2%- Sephardic and 20%- Ashkenazi Jews; p = 0.038), with more gastric polyps (p = 0.017).

Conclusions
We demonstrated a high rate of mutation detection in the heterogeneous population of Israel. Patients from NRFSU with BMPR1A mutation had high rate of gastric involvement.
COVID-19 with peripartum cardiomyopathy: a case report
Authors: Karna Sunaina Tejpal , Thaware Pooja , Singh Pooja 
Published: January 2022

Abstract
Background
The world has been facing the novel coronavirus SARS-CoV-2 pandemic. The novel coronavirus primarily affects the lungs but also affects multiple organ systems including the cardiovascular system causing myocarditis, cardiomyopathy, and arrhythmias. Cardiomyopathy has been reported in patients with COVID-19; however, prognosis of peripartum cardiomyopathy in a patient with COVID-19 is still unexplored. More knowledge is required to understand the incidence of cardiomyopathy due to novel coronavirus SARS-CoV-2.

Case presentation
We report a case of peripartum cardiomyopathy gravida 2 parity 2 COVID-19 confirmed patient who underwent an emergency preterm lower segment caesarean section (LSCS) for severe pre-eclampsia and intra-uterine growth retardation (IUGR) and landed up in acute congestive cardiac failure with pulmonary oedema. A postpartum 32 years female presented to our institute, a dedicated COVID-19 hospital with tachycardia, hypertension, anasarca, tachypnea with desaturation on room air. She had undergone emergency caesarean section for severe preeclampsia with intrauterine growth retardation. On post-operative day 2 (POD2), she complained of shortness of breath. On POD 3 she tested positive RT-PCR for COVID-19 infection. She responded to treatment with steroids. However, on POD6, She developed severe pulmonary oedema with poor ejection fraction necessitating endotracheal intubation and pressure control ventilation. Congestive cardiac failure was managed with diuretics and digoxin. Gradually oxygenation improved. She was electively ventilated for 3 days. Gradually, ejection fraction improved with the resolution of B lines. On the 9th POD, after a successful spontaneous breathing trial, she was extubated and non-invasive ventilation with bi-level positive airway pressure was attached. The patient was gradually tapered off of the non-invasive ventilation over 2 days. On the 11th post-operative day, she was maintaining oxygen saturation on nasal prongs and was sent to the ward.

Conclusions
We recommend early use of bedside lung ultrasonography; echocardiography and close cardiovascular monitoring in severe COVID-19 infected pregnant patients who present with shortness of breath, tachypnea, and hypertensive disorders of pregnancy and previous cardiac abnormalities for expedite management and improved prognosis. An ideal case scenario for extubation may not be present, non-invasive ventilation with bi-level positive airway pressure post-extubation helps in patients with peripartum cardiomyopathy.