bluuebunny/crossref_metadata_2025_split huggingface dataset:
The associations of physical incapacity and wealth with remaining in paid employment after age 60 in five middle-income and high-income countries
Authors: Lu Wentian , Stefler Denes , Sanchez-Niubo Albert , Haro Josep Maria , Marmot Michael , Bobak Martin 
Published: March 2022

AbstractPrevious studies on health and socio-economic determinants of later-life labour force participation have mainly come from high-income European countries and the United States of America (USA). Findings vary between studies due to different measures of socio-economic status and labour force outcomes. This study investigated longitudinal associations of physical incapacity and wealth with remaining in paid employment after age 60 in middle- and high-income countries. Using harmonised cohort data in the USA, England, Japan, Mexico and China (N = 32,132), multilevel logistic regression was applied for main associations. The age-related probabilities of remaining in paid employment by physical incapacity and wealth were estimated using marginal effects. This study found that physical incapacity predicted lower odds of remaining in paid employment in each country. Wealth was associated with higher odds of remaining in paid employment in the USA, England and Japan, but not in Mexico. Probabilities of remaining in paid employment were high in Mexico but low in China. The absolute difference in the probability of remaining in paid employment between the richest and the poorest groups was greater in the USA than that in any other country. In the USA, England and Japan, the inverse association between physical incapacity and remaining in paid employment could be partially compensated by wealth only when physical incapacity was not severe. National policies, including considering older adults’ changing capacities for job placement and prioritising the provision of supportive services for socio-economically disadvantaged older adults, developing pathways for informal workers to access social security and pension coverage, and encouraging employers to hire socio-economically disadvantaged older workers and enhancing their employability, could be facilitated. Future studies, such as exploring health and socio-economic determinants of remaining in part-time and full-time paid employment separately in more countries, and the moderating effects of relevant policies on these associations, are needed.
Adjustable whole-body dynamics for adaptive locomotion: the influence of upper body movements and its interactions with the lower body parts on the stable locomotion of a simple bipedal robot
Authors: Ahmad Huthaifa , Nakata Yoshihiro , Nakamura Yutaka , Ishiguro Hiroshi 
Published: March 2022

AbstractThis paper investigates the influence of adding an upper body to a bipedal robot on its stable walking behavior. The robot’s parts are mutually interconnected through an actuator network system. Therefore, the movement pattern of the upper body depends on the type of interactions created with other limbs. Throughout the experiments, various interactions among the different body parts were tested. The results showed that a robot with a motionless upper body exhibited unstable walking behavior. However, once the same upper body was involved and interacted properly, with other body parts, its movement significantly helped to stabilize the behavior of the robot.
Facilitating More Efficient Negotiations for Innovative Therapies: A Value-Based Negotiation Framework
Authors: Whittal Amanda , Jommi Claudio , De Pouvourville Gérard , Taylor David , Annemans Lieven , Schoonaert Lies , Vermeersch Sebastian , Hutchings Adam , Patris Julien 
Published: March 2022

AbstractObjectivesAn increasing number of innovative therapies (e.g., gene- and cell-based treatments) have been developed in the past 20 years. Despite the significant clinical potential of these therapies, access delays may arise because of differing perspectives of manufacturers and payers regarding issues such as the value of the product, clinical and financial uncertainties, and sustainability.Managed entry agreements (MEAs) can enable access to treatments that would not be reimbursed by conventional methods because of such concerns. However, although MEA typologies exist, there is currently no structured process to come to agreements on MEAs, which can be difficult to decide upon and implement.To facilitate more structured MEA negotiations, we propose a conceptual “value-based negotiation framework” with corresponding application tools.MethodsThe framework was developed based on an iterative process of scientific literature review and expert input.ResultsThe framework aims to (i) systematically identify and prioritize manufacturer and payer concerns about a new treatment, and (ii) select a mutually acceptable combination of MEA terms that can best address priority concerns, with the lowest possible implementation burden.ConclusionsThe proposed framework will be tested in practice, and is a step toward supporting payers and manufacturers to engage in more structured, transparent negotiations to balance the needs of both sides, and enabling quicker, more transparent MEA negotiations and patient access to innovative products.
Optimal management and valuation of a natural resource: the case of optimal harvesting
Authors: Gaïgi M'hamed , Kharroubi Idris , Lim Thomas 
Published: March 2022

AbstractIn this paper, we consider the problem of sustainable harvesting. We explain how the manager maximizes his/her profit according to the quantity of natural resource available in a harvesting area and under the constraint of penalties and fines when the quota is exceeded. We characterize the optimal values and some optimal strategies using a verification result. We then show by numerical examples that this optimal strategy is better than naive ones. Moreover, we define a level of fines which insures the double objective of the sustainable harvesting: a remaining quantity of available natural resource to insure its sustainability and an acceptable income for the manager.
Variability in native and nonnative language: An ERP study of semantic and grammar processing
Authors: Grey Sarah 
Published: March 2022

AbstractThis study examined individual-level variability in N400 and P600 ERP correlates of native and nonnative language sentence processing of semantic and grammar information. Twenty-six native English-speaking learners of Spanish as a second language were tested. Participants completed sentence reading tasks in English and Spanish during EEG recording. The group-level results for grammar showed P600s in the native and nonnative language. For semantics, there was an N400 only in the native language. Individual-level ERP patterns revealed that, for native language semantics, about two thirds of participants showed N400s, but approximately one-third showed P600s. For native language grammar, approximately one third of participants exhibited N400s instead of P600s. Individual-level ERPs showed similar variability in the nonnative language for semantics and grammar, and N400/P600 variability in Spanish related to Spanish verbal fluency and grammar knowledge. This contributes knowledge of how nonnative and native language neurocognition compare regarding the processing routes that individuals use during comprehension.
Transmission of COVID-19 among healthcare workers-an epidemiological study during the first phase of the pandemic in Sweden
Authors: Mathabire Rücker Sekai Chenai , Gustavsson Catharina , Rücker Fredrik , Lindblom Anders , Hårdstedt Maria 
Published: March 2022

Abstract
During the first phase of the COVID-19 pandemic in 2020, concerns were raised that healthcare workers (HCWs) were at high risk of infection. The aim of this study was to explore the transmission of COVID-19 among HCWs during a staff outbreak at an inpatient ward in Sweden 1 March to 31 May 2020. A mixed-methods approach was applied using several data sources. In total, 152 of 176 HCWs participated. The incidence of COVID-19 among HCWs was 33%. Among cases, 48 (96%) performed activities involving direct contact with COVID-19 patients. Contact tracing connected 78% of cases to interaction with another contagious co-worker. Only a few HCW cases reported contact with a confirmed COVID-19 case at home (n = 6; 12%) or in the community (n = 3; 6%). Multiple logistic regression identified direct care of COVID-19 patients and positive COVID-19 family contact as risk factors for infection (adjusted OR 8.4 and 9.0 respectively). Main interventions to stop the outbreak were physical distancing between HCWs, reinforcement of personal hygiene routines and rigorous surface cleaning. The personal protective equipment used in contact with patients was not changed in response to the outbreak. We highlight HCW-to-HCW transmission of COVID-19 in a hospital environment and the importance of preventing droplet and contact transmission between co-workers.
Perfluoroalkyl acid and bisphenol-A exposure via food sources in four First Nation communities in Quebec, Canada
Authors: Dubeau Claudelle , Aker Amira , Caron-Beaudoin Élyse , Ayotte Pierre , Blanchette Caty , McHugh Nancy Gros-Louis , Lemire Mélanie 
Published: March 2022

AbstractObjective:To document perfluoroalkyl acids (PFAA) and bisphenol-A (BPA) exposure in four First Nation communities in northern Quebec compared with the Canadian Health Measures Survey (CHMS Cycle 5 2016–2017) and examine the associations between dietary consumption and chemical exposure.Design:We used cross-sectional data from the JES-YEH! project conducted in collaboration with four First Nation communities in 2015. A FFQ collected information on diet, and PFAA and BPA were measured in biological samples. We used generalised linear models to test the associations between food intake and chemical biomarkers.Setting:Northern Quebec.Participants:Youth aged 3–19 years (n 198).Results:Mean perfluorononanoic acid (PFNA) levels were significantly higher in JES-YEH! than CHMS, and BPA levels were higher among those aged 12–19 years compared with CHMS. Dairy products were associated with PFNA among Anishinabe and Innu participants (geometric mean ratio 95 % CI: 1·53 (95 % CI 1·03, 2·29) and 1·52 (95 % CI 1·05, 2·20), respectively). PFNA was also associated with ultra-processed foods (1·57 (95 % CI 1·07, 2·31)) among Anishinabe, and with wild fish and berries (1·44 (95 % CI 1·07, 1·94); 1·75 (95 % CI 1·30, 2·36)) among Innu. BPA was associated with cheese (1·72 (95 % CI 1·19, 2·50)) and milk (1·53 (95 % CI 1·02, 2·29)) among Anishinabe, and with desserts (1·71 (95 % CI 1·07, 2·74)), processed meats (1·55 (95 % CI 1·00, 2·38)), wild fish (1·64 (95 % CI 1·07, 2·49)) and wild berries (2·06 (95 % CI 1·37, 3·10)) among Innu.Conclusions:These results highlight the importance of better documenting food-processing and packaging methods, particularly for dairy products, and their contribution to endocrine disruptors exposures as well as to promote minimally processed and unpackaged foods to provide healthier food environments for youth in Indigenous communities and beyond.
Malariology and decolonization: Eastern European experts from the League of Nations to the World Health Organization
Authors: Iacob Bogdan C. 
Published: March 2022

AbstractThe article de-centres the global history of disease by examining the agency of Eastern European expertise at international organizations and during decolonization. It challenges accounts of anti-malaria policies at the League of Nations Health Organization and at the World Health Organization written from a Western, particularly North American perspective, or on the basis of local reactions to Western interventions. The contribution proposes an analysis of circulations and ideas across multiple cultural, social and political spaces: post-imperial European states, (post)colonial territories and bureaucracies of international organizations. From the 1920s to the 1960s, Eastern European experts played a crucial role in the transformation of malaria from an imperial disease that tested governance over ‘tropical’ peoples into an issue of global health and nation-state building. However, regional representatives reproduced civilizational hierarchies intrinsic to North–South biomedical relations. The global entanglements of Eastern European malariology show that liberation from disease was less about communism or liberalism, and more about national renewal, statehood and world hierarchies.
The choice between organic and inorganic farming: lessons from Pakistan
Authors: Sabir Muhammad , Ali Yousaf , Abdullah  , Ali Amjad , Khan Jehangir , Ur Rehman Zia- 
Published: March 2022

AbstractThe choice between organic and inorganic farming is an exciting debate in scholarly literature. A large number of studies has enriched the discussion. However, this particular study adds to this debate in unique ways. This study uses a hybrid model based on analytic hierarchy process (AHP) and Technique for Order Preference by Similarity to Ideal Solution (TOPSIS), a methodological contribution to the debate of organic and inorganic farming by using multicriteria decision analysis. Also, this study uses several conflicting criteria (such as health benefits, environmental benefits, soil fertility, consumer awareness, etc.) that have not been combined in a single research study earlier to consider the choice of organic and inorganic farming. The study is based on a questionnaire survey undertaken by consumers, farmers and agriculture experts. After the application of the AHP-TOPSIS based hybrid model, several interesting results have been founded that have important policy implications for farming in Pakistan and other developing countries.
Animals in war: At the vanishing point of international humanitarian law
Authors: Peters Anne , de Hemptinne Jérôme 
Published: March 2022

AbstractAnimals are the unknown victims of armed conflict. They are regularly looted, slaughtered, bombed or starved on a massive scale during such hostilities. Their preservation should become a matter of great concern. However, international humanitarian law (IHL) largely ignores this issue. It only indirectly, and often ambiguously, provides animals with the minimum protection afforded to civilian objects, the environment, and specially protected objects such as medical equipment, objects indispensable for the survival of civilian population or cultural property. This regime neither captures the essence of animals as sentient beings experiencing pain, suffering and distress, nor takes into account their particular needs during wartime. To address these challenges, two strategies are possible: the first strategy would be to apply existing IHL more effectively to animals, if necessary by creative interpretation in line with the animals’ needs. This strategy comprises two options: animals could be included into the categories of combatant/prisoners of war or of civilians. Animals would thus benefit from many guarantees given to human beings in armed conflict. Alternatively, and perhaps more realistically, animals could be equated with “objects” under IHL, while the relevant rules would be reinterpreted to cater for the fact that animals are living beings, experiencing pain, suffering and distress. The second strategy, which could be envisaged as a long-term objective, would be to adopt a new international instrument specifically aimed at granting rights to animals, notably in relation to prohibiting the use of animals as weapons of war.
Protective effect of antioxidants on cardiac function in adult offspring exposed to prenatal overnutrition
Authors: Zhang Jialing , Cao Li , Wang Wenji , Huo Yu , Zheng Yuanzheng , Wu Fang , Gui Yonghao 
Published: March 2022

AbstractMaternal overnutrition-induced fetal programming predisposes offspring to cardiovascular health issues throughout life. Understanding how these adverse cardiovascular effects are regulated at the maternal–fetal crosstalk will provide insight into the mechanisms of these cardiovascular diseases, which will help in further identifying potential targets for intervention. Here, we uncover a role of oxidative stress caused by prenatal overnutrition in governing cardiac damage. Mice exposed to maternal obesity showed remarkable pathological cardiomyocyte hypertrophy (pmale < 0.001, Cohen’s dmale = 1.77; pfemale < 0.001, Cohen’s dfemale = 1.94), increased collagen content (pmale < 0.001, Cohen’s dmale = 2.13; pfemale < 0.001, Cohen’s dfemale = 2.71), and increased levels of transforming growth factor β (TGF-β) (pmale < 0.001, Cohen’s dmale = 3.02; pfemale < 0.001, Cohen’s dfemale = 4.52), as well as left ventricular dysfunction in adulthood. To cope with increased oxidative stress in the myocardial tissue of offspring from obese mothers, we sought to decrease the effect of oxidative stress and prevent the development of these cardiovascular conditions with use of the antioxidant N-acetylcysteine during pregnancy. As predicted, after treatment with the antioxidant, there was greatly mitigated cardiomyocyte hypertrophy (pmale < 0.001, Cohen’s dmale = 1.31; pfemale < 0.001, Cohen’s dfemale = 0.82) and cardiac fibrosis, including decreased composition of collagen fibers (pmale < 0.01, Cohen’s dmale = 1.45; pfemale < 0.05, Cohen’s dfemale = 1.23) and reduced levels of TGF-β (pmale < 0.05, Cohen’s dmale = 1.83; pfemale < 0.01, Cohen’s dfemale = 3.81). We also observed improved left ventricle contractile function together with the alleviation of enhanced oxidative stress in the myocardial tissue of offspring. Collectively, these results established a crucial role of oxidative stress in prenatal overnutrition-associated ventricular remodeling and cardiac dysfunction. Our findings provided an important target for intervention of cardiovascular disease in overnutrition-related fetal programming.
Study of Positive and Negative Affect and Neurocognitive Functioning in Adolescents
Authors: Aritio-Solana Rebeca , Fonseca-Pedrero Eduardo , Pérez-Albéniz Alicia , Mason Oliver , Ortuño-Sierra Javier 
Published: March 2022

Abstract
The main purpose of the present work was to study neurocognitive performance of adolescents at risk for emotional difficulties. The sample included a total of 1,509 adolescents from stratified random cluster sampling. Derived from this sample, a group of high-risk (n = 92) and a comparison group (n = 92) were selected based on the short version of the Positive and Negative Affect Schedule (PANAS) for comparison on the University of Pennsylvania computerized neuropsychological test battery for children (PENN). A Multivariate analysis of covariance (MANCOVA) was performed taking the scores on the PENN as dependent variables and the two groups derived from the scores of the PANAS (at risk vs. comparison) as a fixed factor. Adolescents at high risk of presenting affectivity problems showed statistically significant differences in several different neurocognitive domains, in accuracy, λ = .820, F(9, 160,000) = 3.913, p < .01, partial η² = .180; speed, λ = .502, F(5, 88,000)= 17.493, p < .01, partial η² = .498; and efficiency, λ = .485, F(4, 89,000) = 23.599, p <.01, partial η² = .515. The high risk group showed lower neurocognitive performance than the comparison group. In addition, a positive statistically significant correlation was found between all the neurocognitive competences (p < .05). Results found in this study reveal that neurocognitive impairments can be shown in adolescents at psychometric high risk for emotional problems before transition to more severe psychological problems.
Geostatistics of the Borden Aquifer: High‐Resolution Characterization Using Direct Groundwater Velocity Measurements
Authors: Osorno T. C. , Devlin J. F. , Bohling G. C. 
Published: March 2022

AbstractIn 1986, a seminal data set from the Canadian Forces Base (C.F.B.) Borden aquifer, Ontario, Canada, was published, illustrating, in unprecedented detail, the spatial distribution of hydraulic conductivity (K). Among many contributions attached to that data set was a geostatistical examination of field‐based data for comparison with theoretical predictions of macro‐dispersivity. However,that work treatedKas a static parameter and the sole source of flow variability. Here, point velocity probes (PVPs) are used to extend the earlier work by collecting a novel high‐resolution data set of groundwater velocity (v) measurements in the C.F.B. Borden aquifer. Velocity is a dynamic parameter of fundamental importance, closely tied to solute dispersion. Over 400 velocity measurements were collected along a transect perpendicular to flow, analyzed geostatistically, and compared with the analysis of the B‐B′ cross‐section ofKreported by Sudicky (1986),https://doi.org/10.1029/wr022i013p02069. The PVP measurements exhibited geostatistics similar to those previously estimated by Sudicky (1986),https://doi.org/10.1029/wr022i013p02069. This finding suggests, as implicitly assumed in the previous work, the distribution ofvis primarily controlled byK. PVPs also provided a novel, high‐resolution data set of groundwater flow directions. Since the ultimate objective of aquifer characterization includes the definition of velocity fields, this work not only extends the 1986 work, but also demonstrates a viable alternative for characterizing flow patterns in aquifers—with the advantage thatdirect vmeasurements reflect variability in porosity and hydraulic gradient, as well asK. This could ultimately be advantageous at sites with greater heterogeneity or other dynamic hydrogeological variabilities more pronounced than those at the Borden site.
Attribution of Space‐Time Variability in Global‐Ocean Dissolved Inorganic Carbon
Authors: Carroll Dustin , Menemenlis Dimitris , Dutkiewicz Stephanie , Lauderdale Jonathan M. , Adkins Jess F. , Bowman Kevin W. , Brix Holger , Fenty Ian , Gierach Michelle M. , Hill Chris , Jahn Oliver , Landschützer Peter , Manizza Manfredi , Mazloff Matt R. , Miller Charles E. , Schimel David S. , Verdy Ariane , Whitt Daniel B. , Zhang Hong 
Published: March 2022

AbstractThe inventory and variability of oceanic dissolved inorganic carbon (DIC) is driven by the interplay of physical, chemical, and biological processes. Quantifying the spatiotemporal variability of these drivers is crucial for a mechanistic understanding of the ocean carbon sink and its future trajectory. Here, we use the Estimating the Circulation and Climate of the Ocean‐Darwin ocean biogeochemistry state estimate to generate a global‐ocean, data‐constrained DIC budget and investigate how spatial and seasonal‐to‐interannual variability in three‐dimensional circulation, air‐sea CO2 flux, and biological processes have modulated the ocean sink for 1995–2018. Our results demonstrate substantial compensation between budget terms, resulting in distinct upper‐ocean carbon regimes. For example, boundary current regions have strong contributions from vertical diffusion while equatorial regions exhibit compensation between upwelling and biological processes. When integrated across the full ocean depth, the 24‐year DIC mass increase of 64 Pg C (2.7 Pg C year−1) primarily tracks the anthropogenic CO2 growth rate, with biological processes providing a small contribution of 2% (1.4 Pg C). In the upper 100 m, which stores roughly 13% (8.1 Pg C) of the global increase, we find that circulation provides the largest DIC gain (6.3 Pg C year−1) and biological processes are the largest loss (8.6 Pg C year−1). Interannual variability is dominated by vertical advection in equatorial regions, with the 1997–1998 El Niño‐Southern Oscillation causing the largest year‐to‐year change in upper‐ocean DIC (2.1 Pg C). Our results provide a novel, data‐constrained framework for an improved mechanistic understanding of natural and anthropogenic perturbations to the ocean sink.