bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term health-related quality of life in patients with ruptured arteriovenous malformations treated in childhood
Authors: Oulasvirta Elias , Pohjola Anni , Koroknay-Pál Päivi , Hafez Ahmad , Roine Risto , Sintonen Harri , Laakso Aki 
Published: June 2022

OBJECTIVE
The aim of this study was to reveal the long-term health-related quality of life (HRQOL), educational level, and impact on occupation in 55 patients who experienced ruptured brain arteriovenous malformations (AVMs) that were treated during childhood.

METHODS
In 2016, questionnaires including the 15D instrument were sent to all living patients older than 18 years (n = 432) in the Helsinki AVM database. The cohort was further specified to include only patients with ruptured AVMs who were younger than 20 years at the time of diagnosis (n = 55). Educational level was compared with the age-matched general population of Finland. The mean 15D scores were calculated for independent variables (Spetzler-Ponce classification, admission age, symptomatic epilepsy, and multiple bleeding episodes) and tested using the independent-samples t-test or ANCOVA. Linear regression was used to create a multivariate model. Bonferroni correction was used with multiple comparisons.

RESULTS
The mean follow-up time from diagnosis to survey was 24.2 (SD 14.7) years. The difference in the mean 15D scores between Spetzler-Ponce classes did not reach statistical significance. The youngest age group (< 10 years at the time of diagnosis) performed less well on the dimension of usual activities than the older patients. Symptomatic epilepsy significantly reduced the long-term HRQOL. Multiple hemorrhages significantly reduced the scores on three dimensions: mobility, speech, and sexual activity. In the regression model, symptomatic epilepsy was the only significant predictor for a lower 15D score. The educational level of the cohort was for the most part comparable to that of the general population in the same age group. AVM was the reason for early retirement in 11% of the patients, while lowered performance because of the AVM was reported by 37% of the patients.

CONCLUSIONS
Patients with ruptured AVMs treated in childhood can live an independent and meaningful life, even in the case of the highest-grade lesions. Symptomatic epilepsy significantly reduced the long-term HRQOL, highlighting the need for continuing support for these patients.
ADYGHE (CIRCASSIAN) DIASPORA IN THE POLITICAL AND SOCIOCULTURAL SPACE OF THE NEAR AND MIDDLE EAST: TO THE ISSUE OF IMMANENT POLITICAL CONFORMISM
Authors: Kudaeva Svetlana G. 
Published: June 2022

Currently, the North-Caucasian diaspora consists mainly of Adyghe people (Circassians) and, according to unofficial data, numbers from 3 to 5 million people; at the same time, their number in their historical homeland slightly exceeds 700,000 people. Such state of the Adyghe ethic group was the result of events of the Caucasian War, when most of its population had to flee from their historical land and settle in the countries of the Near and Middle East. Naturally, a historical phenomenon of this magnitude could not but attract interest from the scientific community. To date, we possess enough works on the theory of diasporas, based on the experience of studying Jewish diaspora. This makes it possible to single out key criteria, typical for “classical” (historical) diasporas and extrapolate them on the Adyghe dispersion. The present paper studies one such criteria – immanent political conformism, i.e. a specific attitude of a diaspora to the political system of the country of residence, the opportunity to be productive within the receptive state. This process can be considered in the dynamics, which allows to trace the transformation of the status of the Adyghe community on different stages in connection with the fluctuations of the socio-political situation in the countries of their new residence. The specificity of the issue under question has led to the use of a wide range of methods and principles of historical research. These are retrospective, systematic and problem-chronological methods, which, coupled with the principles of historicism and objectivity, allowed for reconstruction of a full picture of the past and present in the context of interrelations and interdependence. During our study, we have come to a well-grounded conclusion that Adyghe people (Circassians) today represent high-status, integrated groups within the countries of their residence.
THE SIEMENS’ “GADABAY POSSESSION” IN TRANSCAUCASIA
Authors: Neklyudov Evgeny G. 
Published: June 2022

The article presents the history of the so-called “Gadabay possession”, which was the allotment of public lands and forests to the Gadabay and Kalakend copper smelters in Transcaucasia in the second half of the 19th – early 20th centuries. With its help, one of the largest mining enterprises in the region was organized, which belonged to the famous entrepreneurs of the Prussian origin – the Siemens. Forest allotments were required for the procurement of wood fuel for metallurgical furnaces. Using the example of business correspondence between owners and directors of enterprises with regional and central mining authorities, we demonstrate how the conditions of possession, which form the basis of the relationship between owners and the state, influenced the progressive development of the region’s largest mining enterprise. At a certain stage, the rigid connection of the size of forest allotments to the annual productivity of enterprises began to restrict the growth of production, which, in the context of falling market prices, was the only way for the plants to survive. The severity of the fuel problem, on the one hand, caused difficulties in relations with the regional mining administration and an increase in overhead costs, but on the other hand, it pushed the plant management to introduce the latest methods of copper smelting and the use of fossil fuels. Possessional legal relations turned out to be one of the factors that forced the owners to abandon not only forest allotments, but also the further exploitation of a large industrial business, established by many years of hard work.
SENI PERTUNJUKAN TRADISIONAL (JAWA) ERA REFORMASI
Authors: Suparno T. Slamet 
Published: June 2022

The aim of this study is to obtain a more in-depth explanation regarding the prob- lems in the life of classical Javanese performance from a sociological-artistic angle, in the face of changes that have occurred in the environment during the postÂ Orde BaruÂ era.Â Â Nevertheless, in order to gain a clear picture about the changes during each era, this study also covers the life of classical Javanese performance during the two previous era, namely the era preceding theÂ Orde BaruÂ and theÂ Orde BaruÂ era itself. Â This problem includes a general picture of the life of classical Javanese performance during these three periods, in particular at the time of this research. The next problem is concerned with the possibility of change occurring in the pat- tern of classical Javanese performances during the same period, and the nature of these new patterns, including which aspects, and with Â what substance.Â Â Likewise, to what extent are the aspects related to social change and Â social phenomena re- flected in classical Javanese performance a response from the artist, in connection with preserving his existence.In accordance with its goal, this study uses a sociological-artistic approach, from the Â result of Arnold Hauserâ€™s ideas in his bookÂ The Sociology of Art.Â Â This ap- proach principally looks at the relation between a community and its art. Â Classical Javanese performance is made up of a number of different elements, including its group, equipment, and audience. Â Arnold Hauser explains that social changes in a given area will result in a unique artistic style, in accordance with the form of the community at that particular time. Â An art form which in a certain period may be considered as a ritual art, Â may have the potential to be used as a tool of propa- ganda by the authority or even emerge as a form of popular art.Based on the results of the research, classical Javanese performance has a ten- dency Â to Â stand alone in each of the three eras, according to the changes in its environment.Â Â During the era prior to theÂ Orde Baru,Â classical Javanese was en- joyed mainly by the Â agrarian community, who were influenced by arts from the court.Â Â During theÂ Orde Â BaruÂ era, performances were not only enjoyed by the agrarian community but also by the urban community as it spread to towns outside the court territory. At the present time, classical Javanese performances are coloured by government development policies and for Â this reason are often used as a gov- ernment tool for conveying messages about Â development.Â Â In addition, during theÂ Orde BaruÂ era, other art forms began to penetrate and influence the form of clas- sical Javanese performance. Â In the postOrde BaruÂ era, its form has become moreopen, as a result of the euphoria created by an excess of reformation, and it has become difficult to identify. Â Furthermore, it is evident that audiences can no longer respond to the Â moral messages conveyed in a classical Javanese performance.Â Key words:Â classical Javanese performance, group, audience.
SIMBOLISME PATUNG LORO BLONYO
Authors: Sulistyo Edy Tri , Wiwoho Jamal 
Published: June 2022

The objectives of research are to find out: (1) the cosmology form ofÂ loro blonyoÂ sculpture in Javanese cultural context, (2) placement system of loro blonyoÂ sculp- ture in Â â€œjogloâ€Â house structure relating to the concept of Javanese social-cultural environment Â balance, (3)Â loro blonyoÂ sculpture as the most important element in its position in Â â€œpasrÃ¨nâ€Â room in Javanese custom house, and (4) the symbolic- philosophical meaning ofÂ loro blonyoÂ sculpture art in Javanese cultural cosmology. Based on the result of Â research and discussion, it can be concluded: (1) The cos- mology form ofÂ loro blonyo Â sculpture in the Javanese cultural context relating to the Javanese society particularly the one with rice planting as the earning; (2) The placement system ofÂ loro blonyoÂ sculture in theÂ â€œjogloâ€Â house structure relating to the concept of Javanese social-cultural environment balance; (3)Â Loro blonyoÂ sculp- ture is the most important element in its position in theÂ â€œpasrÃ¨nâ€Â room in Javanese custom house;.Â Â (4) The symbolic-philosophical meaning of Â loro blonyoÂ sculpture art in Javanese cultural cosmology is as the symbol of fertility (Dewi Sri) and pros- perity (Sadana).Key words:Â loro blonyo, krobongan, pasrÃ¨n or petanÃ¨n, joglo, Dewi Sri, Sadana.
TRANSFORMASI SERAT PARTAWIGENA DALAM LAKON WAHYU PAKEM MAKUTHARAMA
Authors: Masturoh Titin 
Published: June 2022

This research aims to find some answers to the questions: (1) what are the intrin- sic elements ofÂ Serat PartawigenaÂ written by KPA. Kusumadiningrat like? (2) how wasÂ Serat Â PartawigenaÂ transformed intoÂ Lakon Wahyu Pakem MakutharamaÂ us- ing reception and inter-textual approaches and the intrinsic and extrinsic elements as well as their transformation were analyzed.The result of the research shows that the text contains an ethic education message to the Â descendants and the next generation, especially future leaders.Â Â The intrin- sic elements Â ofÂ Serat PartawigenaÂ contains the element of plot, characterizing, setting, theme and Â message.Â Â The setting element covers place, time and atmo- sphere aspect. Â The theme element includes the main theme and additional theme. The extrinsic element inSerat Â PartawigenaÂ contains ethiceducation values which are the requirements for being a leader. Â In addition to that, the element also con- tains seven darkness of the world which Â have to be avoided by leader and seven darkness which make the body dirty. Â The transformation from ofSerat PartawigenaÂ inÂ Lakon Wahyu Pakem MakutharamaÂ exists in the pattern of plot, characterizing, characterization, setting and ethic education values.Â Keywords:Â Serat Partawigena, transformation
PERUBAHAN PARADIGMA TEOLOGI GEREJA KRISTEN JAWA (GKJ) PITURUH PURWOREJO DAN DAMPAKNYA TERHADAP MUSIK IBADAH
Authors: Labeti Uri Christian Sakti 
Published: June 2022

Artikel ini merupakan hasil analisis pandangan teologi gereja yang termanifestasikan dalam dogma maupun praktik kehidupan gereja. Dalam sejarah, Gereja Kristen Jawa (GKJ) terhegemoni oleh pandangan teologi Zending, yang mengakibatkan tercerabutnya gereja dari akar budayanya. GKJ Pituruh unik dibandingkan GKJ lain, karena budaya menjadi bagian integral kehidupan gereja, oleh karena itu muncul pertanyaan dalam penelitian yang menyangkut latar belakang perubahan paradigma teologi GKJ Pituruh, alasan mengapa Kentrung digunakan sebagai musik ibadah, bagaimana kekuatan Kentrung dalam menciptakan atmosfir ibadah, dan dampak Kentrung terhadap perilaku gereja, serta pandangan masyarakat. Hasilnya, pertama, teologi lokal GKJ Pituruh menjadi dasar penerimaan Kentrung sebagai musik ibadah. Kedua, Kentrung menjadi simbol identitas gereja yang kontekstual dan berbasis budaya Jawa. Ketiga, Kentrung berdampak terhadap perilaku gereja dan pandangan masyarakat. Pandangan teologi lokal GKJ Pituruh membawa pengaruh terhadap identitasnya sebagai gereja Jawa.Â Kata kunci:Â teologi lokal, Kentrung, musik ibadah, pandangan gereja.
Sukellus syväsivistykseen
Authors: Lang Tarja 
Published: June 2022

Syväsivistys tulee tarpeeseen. Mikä olisi tärkeämpää kuin ihmiskunnan ekologisen arvopohjan vahvistaminen ja syvyyden hakeminen nykyiseen, välillä pinnalliseen, sivistyskeskusteluun? Björn Wallén käsittelee aihepiiriä lavealla ja persoonallisen luovalla otteella. Lopputulos on maailman taloudellista ja teknistä kehitystä kritisoiva pamfletti. Sen syntyyn ovat vaikuttaneet kirjoittajan syvä henkilökohtainen luontoyhteys, pitkä työkokemus kansansivistyksestä ja kiinnostus sivistysfilosofian traditioihin.
Processo de adesão do adolescente à assistência odontológica na atenção primária, sob a perspectiva de seus familiares
Authors: Rodrigues Adriana Guimarães , Faria Daniela Aparecida de , Pedras Ana Clara Rios Pimenta , Milagre Natália Marques Resende , Henrique Rocha Gonçalves Ferreira Emílio , Rosas Cesar Perini , Araújo Alisson 
Published: June 2022

A adolescência é uma fase de crescimento rápido e de transformações físicas, sociais e psicológicas pelas quais o indivíduo passa da infância ao estado adulto. Nessa fase os adolescentes podem apresentar comportamentos que impactam negativamente a sua saúde geral e bucal, como alimentação inadequada, sedentarismo, o uso de álcool e drogas, entre outros. Um grande desafio para as equipes da atenção primária a saúde é a adesão do paciente adolescente ao tratamento. Sabe-se também que a família exerce grande influência sobre os hábitos e comportamento do adolescente. Dessa forma, o propósito deste trabalho é compreender o processo de adesão do adolescente à assistência odontológica na atenção primária, sob a perspectiva de seus familiares, com suas implicações na saúde bucal. Este é um estudo qualitativo fundamentado na Fenomenologia de Martin Heidegger. Os autores identificaram com a pesquisa fatores que dificultam o acesso ao serviço odontológico, e fatores relacionados à chegada da adolescência que influenciam na adesão e acompanhamento odontológico.
Variante no gene receptor da vitamina D e sua relação com a fibromialgia
Authors: Zanatta Grazielle , Muller Lara Cassemiro , Sella Ana Luísa Berti Guimarães , Frederico Regina Celia Poli 
Published: June 2022

Objetivo: Compreender a relação da fibromialgia com a variante genética, Cdx2, do gene VDR que codifica receptor de vitamina D e avaliar a associação das características clínicas dos participantes do estudo com as variantes genotípicas e alélicas do gene VDR. Métodos: é um estudo caso-controle, quantitativo e experimental que recrutou 65 indivíduos, porém pelos fatores de exclusão aplicados somente 62 participaram efetivamente, sendo 33 com FM e 29 do grupo controle. Foram aplicados 5 questionários para aqueles com a doença e somente 1 para aqueles sem. O polimorfismo estudado, do cdx2, promove uma troca de G/A, no cromossomo 12q13.11, encontrado por meio da técnica de qPCR. Resultados: Pela análise dos genótipos 54,8% (34/62) dos participantes eram GG, 32,3% (20/62) GA e o genótipo AA estava presente em 12,9% (8/62). Dos participantes, 83,9% (52/62) eram do sexo feminino e 74,2% (46/62) brancos. A variante genética, Cdx2, se correlacionou estatísticamente com a FM (p= 0,004), onde 66.7% dos pacientes com FM apresentaram o genótipo GG, sendo que os portadores do genótipo GG/GA apresentaram 12,6 vezes mais chances de desenvolver a FM (OR=12,57; IC95%: 1,465-107,889; p = 0,001) em relação aos indivíduos com o genótipo AA. Conclusão: O polimorfismo do Cdx2 (AA) aumenta a expressão do receptor e assim, inibe a resposta Th1 e ativa a Th2 melhorando a resposta a vitamina D, atuando como um fator protetor para o individuo sem a doença.
Bioengineered Human Stromal Lenticule for Recombinant Human Nerve Growth Factor Release: A Potential Biocompatible Ocular Drug Delivery System
Authors: Mastropasqua Leonardo , Nubile Mario , Acerra Giuseppina , Detta Nicola , Pelusi Letizia , Lanzini Manuela , Mattioli Simone , Santalucia Manuela , Pietrangelo Laura , Allegretti Marcello , Dua Harminder S. , Mehta Jodhbir S. , Pandolfi Assunta , Mandatori Domitilla 
Published: June 2022

Small incision lenticule extraction (SMILE), is a surgical procedure for the myopia correction, during which a corneal stromal lenticule is extracted. Given that we have previously demonstrated how this discarded tissue could be repurposed as a bio-scaffold for stromal engineering, this study aimed to explore its use as an ocular drug delivery system of active molecules, using neurotrophic factor Nerve Growth Factor (NGF). We employed human stromal lenticules directly collected from healthy donors undergoing SMILE. Following a sodium dodecylsulfate (SDS) treatment, decellularized lenticules were incubated with a suspension of polylactic-co-glycolic-acid (PLGA) microparticles (MPs) loaded with recombinant human NGF (rhNGF-MPs). Fluorescent MPs (Fluo-MPs) were used as control. Data demonstrated the feasibility to engineer decellularized lenticules with PLGA-MPs which remain incorporated both on the lenticules surface and in its stromal. Following their production, the in vitro release kinetic showed a sustained release for up to 1 month of rhNGF from MPs loaded to the lenticule. Interestingly, rhNGF was rapidly released in the first 24 h, but it was sustained up to the end of the experiment (1 month), with preservation of rhNGF activity (around 80%). Our results indicated that decellularized human stromal lenticules could represent a biocompatible, non-immunogenic natural scaffold potential useful for ocular drug delivery. Therefore, combining the advantages of tissue engineering and pharmaceutical approaches, this in vitro proof-of-concept study suggests the feasibility to use this scaffold to allow target release of rhNGF in vivo or other pharmaceutically active molecules that have potential to treat ocular diseases.
Isolating the Effect of Arch Architecture on Aortic Hemodynamics Late After Coarctation Repair: A Computational Study
Authors: Goodarzi Ardakani Vahid , Goordoyal Harshinee , Ordonez Maria Victoria , Sophocleous Froso , Curtis Stephanie , Bedair Radwa , Caputo Massimo , Gambaruto Alberto , Biglino Giovanni 
Published: June 2022

ObjectivesEffective management of aortic coarctation (CoA) affects long-term cardiovascular outcomes. Full appreciation of CoA hemodynamics is important. This study aimed to analyze the relationship between aortic shape and hemodynamic parameters by means of computational simulations, purposely isolating the morphological variable.MethodsComputational simulations were run in three aortic models. MRI-derived aortic geometries were generated using a statistical shape modeling methodology. Starting from n = 108 patients, the mean aortic configuration was derived in patients without CoA (n = 37, “no-CoA”), with surgically repaired CoA (n = 58, “r-CoA”) and with unrepaired CoA (n = 13, “CoA”). As such, the aortic models represented average configurations for each scenario. Key hemodynamic parameters (i.e., pressure drop, aortic velocity, vorticity, wall shear stress WSS, and length and number of strong flow separations in the descending aorta) were measured in the three models at three time points (peak systole, end systole, end diastole).ResultsComparing no-CoA and CoA revealed substantial differences in all hemodynamic parameters. However, simulations revealed significant increases in vorticity at the site of CoA repair, higher WSS in the descending aorta and a 12% increase in power loss, in r-CoA compared to no-CoA, despite no clinically significant narrowing (CoA index &gt;0.8) in the r-CoA model.ConclusionsSmall alterations in aortic morphology impact on key hemodynamic indices. This may contribute to explaining phenomena such as persistent hypertension in the absence of any clinically significant narrowing. Whilst cardiovascular events in these patients may be related to hypertension, the role of arch geometry may be a contributory factor.
Theophylline Use to Prevent Permanent Pacing in the Contemporary Era of Heart Transplantation: The Rotterdam Experience
Authors: Kooij Claudette , Szili-Torok Tamas , Roest Stefan , Constantinescu Alina A. , Brugts Jasper J. , Manintveld Olivier , Caliskan Kadir 
Published: June 2022

IntroductionSinus node dysfunction and atrioventricular conduction disorders occur increasingly after orthotopic heart transplantation (HTX) due to aging donors and may require permanent pacemaker (PM) implantation. Theophylline has been used in the past in selected cases as an alternative to PM implantation.PurposeThe aim of this study was to investigate the rate and success of oral theophylline administration after orthotopic heart transplantation preventing permanent PM implantation.MethodsWe included all patients treated with theophylline post HTX due to bradyarrhythmia's in our center from January 1985 to January 2020. Data was obtained retrospectively through electronic patient files. Re-transplants and patients who died within 1 month post HTX were excluded from the analysis.ResultsOf the total of 751 heart transplant recipients, 73 (9,7%) patients (mean age 46 ± 15.2 years; 73% male) were treated with theophylline for bradyarrhythmia's early post HTX. Of these patients, 14 (19%) patients needed a permanent PM during hospitalization and 10(14%) patients stopped using theophylline because of adequate heart rhythm. In the end, 49 (6.5% of the total) patients were discharged with a theophylline (mean maintenance doses of 354 ± 143 mg). At the outpatient clinics, additional 6 (12%) patients needed a PM within 7 months after discharge, with the rest stable sinus rhythm.ConclusionIn this retrospective data analyses oral theophylline remained a viable alternative to permanent PM implantations in patients post HTX with increased heart rates, facilitating the withdrawal of chronotropic support and avoiding the need of permanent PM implantation.