bluuebunny/crossref_metadata_2025_split huggingface dataset:
Untargeted metabolomic analyses reveal the diversity and plasticity of the specialized metabolome in seeds of different Camelina sativa genotypes
Authors: Boutet Stéphanie , Barreda Léa , Perreau François , Totozafy Jean‐Chrisologue , Mauve Caroline , Gakière Bertrand , Delannoy Etienne , Martin‐Magniette Marie‐Laure , Monti Andrea , Lepiniec Loïc , Zanetti Federica , Corso Massimiliano 
Published: January 2022

SUMMARYDespite the essential role of specialized metabolites (SMs) in the interaction of plants with the environment, studying the ability of crop seeds to produce these protective compounds has been neglected. Furthermore, seeds produce a myriad of SMs, providing an interesting model to investigate their diversity and plasticity. Camelina sativa gained a lot of interest in the past few years as a rustic oilseed crop. A characterization of seed SM landscapes in six camelina genotypes grown in the field and harvested during five growing seasons has been undertaken in this work. This allowed a comprehensive annotation of seed SMs combining analyses that cluster SMs based on their chemical structures and co‐accumulation patterns. These data showed broad effects of the environment on the stimulation of the seed SM. Among well‐annotated compounds, flavonols were identified as the metabolic class characterized by high plasticity, revealing significant variable accumulation according to the year and/or the genotype. Lastly, a deeper characterization of primary metabolites and lipids in two selected genotypes has been performed. We showed that, in addition to flavonols, alkaloids and glucosinolates displayed a higher phenotypic plasticity with respect to most of the primary metabolites, including some sugars and major storage compounds such as fatty acids, proteins and most lipid classes (e.g. diacylglycerols, triacylglycerols), but similar plasticity compared with free amino acids and carboxylic acids. This work highlighted major and unexplored effects of the environment on the seed SM, demonstrating that seeds exhibit a dynamic and plastic metabolism, with an impact on seed quality.
Economic implications of FDA platelet bacterial guidance compliance options: Comparison of single‐step strategies
Authors: Prioli Katherine M. , Abersone Ilze , Kopko Patricia M. , Herman Jay H. , Custer Brian , Pizzi Laura T. 
Published: January 2022

AbstractBACKGROUNDBloodborne pathogens pose a major safety risk in transfusion medicine. To mitigate the risk of bacterial contamination in platelet units, FDA issues updated guidance materials on various bacterial risk control strategies (BRCS). This analysis presents results of a budget impact model updated to include 5‐ and 7‐day pathogen reduced (PR) and large volumed delayed sampling (LVDS) BRCS.STUDY DESIGN AND METHODSModel base‐case parameter inputs were based on scientific literature, a survey distributed to 27 US hospitals, and transfusion experts' opinion. The outputs include hospital budget and shelf‐life impacts for 5‐ and 7‐day LVDS, and 5‐ and 7‐day PR units under three different scenarios: (1) 100% LVDS, (2) 100% PR, and (3) mix of 50% LVDS ‐ and 50% PR.RESULTSTotal annual costs from the hospital perspective were highest for 100% LVDS platelets (US$2.325M) and lowest for 100% PR‐7 units (US$2.170M). Net budget impact after offsetting annual costs by outpatient reimbursements was 5.5% lower for 5‐day PR platelets as compared to 5‐day LVDS (US$1.663 vs. US$1.760M). A mix of 7‐day LVDS and 5‐day PR platelets had net annual costs that were 1.3% lower than for 100% 7‐day LVDS, but 1.3% higher than for 100% 5‐day PR. 7‐day PR platelets had the longest shelf life (4.63 days), while 5‐day LVDS had the shortest (2.00 days).DISCUSSIONThe model identifies opportunities to minimize transfusion center costs for 5‐ and 7‐day platelets. Budget impact models such as this are important for understanding the financial implications of evolving FDA guidance and new platelet technologies.
Impact of Engaging the Nonthrowing Arm on Maximal Ball Velocity From an Overhand Throw With Both the Dominant and Nondominant Arms: A Pilot Study
Authors: Weisberg Alanna , Suk Lee Hyun , Fung Tak , Katz Larry 
Published: January 2022

The overhand throw is a complex whole-body motor skill that is fundamental to many sports and activities. When throwing properly, the momentum generated to complete the movement begins in the lower body and transfers through the trunk to the throwing arm. This proof-of-concept study’s primary purpose was to evaluate the impact of the nonthrowing arm on the ball speed during an overhand throw with both the dominant and nondominant arms. Eighteen participants (age: 20.20 ± 2.90 years, nine women) were divided into two intervention groups: a pulling group taught to engage the nonthrowing arm through a pull toward the body and a nonpulling group taught the overhand throw using a component-based physical education curriculum. Each participant completed 12 total throws, six for each side (dominant and nondominant arm). Ball speed and kinematic data were collected using an eight-camera motion analysis system and were assessed using a pre–post study design. The two groups showed significant improvements pre–post when throwing with both the dominant and nondominant arms. Based on effect size comparisons, engaging the nonthrowing arm makes a meaningful difference in maximal ball velocity.
Maternal Physical Activity at Term and Spontaneous Labor: A Case-Crossover Study
Authors: Nulty Alison K. , Bovbjerg Marit L. , Savitz David A. , Herring Amy H. , Bradley Chyrise B. , Evenson Kelly R. 
Published: January 2022

Background: This study assessed associations between antenatal physical activity and the onset of spontaneous labor (SL). Methods: Data were taken from 541 participants in the third pregnancy, infection, and nutrition study who had no contraindications to antenatal physical activity. An interviewer-administered questionnaire assessed labor triggers, gestational age at birth, and physical activity within the week (24 h to 7 d) and the 24-hour period (0–24 h) prior to SL. A case-crossover design examined the association between physical activity (recreational, occupational, or any) and the risk of onset of SL within the subsequent 24 hours. Results: Overall, 21% (any), 26% (recreational), and 14% (occupational) of participants reported physical activity during the week; whereas 5% (any), 7% (recreational), and 3% (occupational) reported physical activity during the 24-hour period, prior to SL onset. Participants who reported any or occupational physical activity during the 24-hour period had a decreased likelihood of SL within the subsequent 24 hours, while participants who reported at least 30 minutes of recreational physical activity had an increased likelihood. Results remained consistent among early, full, or postterm participants. Conclusion: Recreational, but not occupational, physical activity at term may increase the likelihood of SL; however, the authors cannot rule out reverse causality.
Kinesiology’s Social Justice Imperative
Authors: Cardinal Bradley J. 
Published: January 2022

Kinesiology is a field focused on physical activity and its impact on health, society, and quality of life. But do all people have equal opportunities to access and experience physical activity? Do physical activity settings allow people to freely express themselves? Are the benefits of physical activity universally shared by all people? If the answer to any of these questions is “no,” then these questions demand not only our immediate attention, but also our collective action. During the National Academy of Kinesiology’s 90th anniversary meeting, September 22–24, 2021, these questions and others were explored through presentations devoted to the theme “Kinesiology’s Social Justice Imperative.” This essay overviews the meeting, its purpose, and the organizers and introduces the 11 thematic papers in the “Proceedings of the National Academy of Kinesiology’s 2021 Meeting: Kinesiology’s Social Justice Imperative” issue, plus a 12th essay commemorating the National Academy of Kinesiology’s 90th anniversary meeting.
MODELING AND MULTI-RESPONSE OPTIMIZATION OF ABRASIVE WATER JET MACHINING USING ANN COUPLED WITH NSGA-II
Authors: CHANDGUDE ABHIMANYU K. , BARVE SHIVPRAKASH B. 
Published: January 2022

This paper aims to develop a predictive model and optimize the performance of the abrasive water jet machining (AWJM) during machining of carbon fiber-reinforced plastic (CFRP) epoxy laminates composite through a unique approach of artificial neural network (ANN) linked with the nondominated sorting genetic algorithm-II (NSGA-II). Initially, 80 AWJM experimental runs were carried out to generate the data set to train and test the ANN model. During the experimentation, the stand-off distance (SOD), water pressure, traverse speed and abrasive mass flow rate (AMFR) were selected as input AWJM variables and the average surface roughness and kerf width were considered as response variables. The established ANN model predicted the response variable with mean square error of 0.0027. Finally, the ANN coupled NSGA-II algorithm was applied to determine the optimum AWJM input parameters combinations based on multiple objectives.
Compression of Deep Learning Models for Text: A Survey
Authors: Gupta Manish , Agrawal Puneet 
Published: January 2022

In recent years, the fields of natural language processing (NLP) and information retrieval (IR) have made tremendous progress thanks to deep learning models like Recurrent Neural Networks (RNNs), Gated Recurrent Units (GRUs) and Long Short-Term Memory (LSTMs) networks, and Transformer [
121
] based models like Bidirectional Encoder Representations from Transformers (BERT) [
24
], Generative Pre-training Transformer (GPT-2) [
95
], Multi-task Deep Neural Network (MT-DNN) [
74
], Extra-Long Network (XLNet) [
135
], Text-to-text transfer transformer (T5) [
96
], T-NLG [
99
], and GShard [
64
]. But these models are humongous in size. On the other hand, real-world applications demand small model size, low response times, and low computational power wattage. In this survey, we discuss six different types of methods (Pruning, Quantization, Knowledge Distillation (KD), Parameter Sharing, Tensor Decomposition, and Sub-quadratic Transformer-based methods) for compression of such models to enable their deployment in real industry NLP projects. Given the critical need of building applications with efficient and small models, and the large amount of recently published work in this area, we believe that this survey organizes the plethora of work done by the “deep learning for NLP” community in the past few years and presents it as a coherent story.
Atualidade/necessidade do pensamento de Paulo Freire: a experiência da prática docente em um cursinho popular
Authors: De Luca Angélica , Infante-Malachias María Elena 
Published: January 2022

Neste artigo, apresentamos uma interpretação à luz do pensamento de Paulo Freire sobre a prática de um cursinho popular localizado na cidade de Itapevi, região periférica da grande São Paulo. As práticas desses cursinhos podem reatualizar o pensamento de Paulo Freire e preservá-lo do esquecimento ou da ruína de leituras distorcidas e equivocadas. O estudo realizado a partir de um grupo focal com quatro professores voluntários revelou que estes professores, embasados em uma concepção de educação para além do que é “possível”, propõem e oferecem uma formação humana crítica aos seus estudantes, questionam a própria prática educativa e o vestibular. A educação popular desenvolvida nos cursinhos populares, além de atualizar a relevância políticopedagógica do pensamento de Paulo Freire,torna-se cada vez mais urgente e necessária para que se consolide uma verdadeira cultura democrática.
Associations Between Blood Pressure and Accelerated DNA Methylation Aging
Authors: Xiao Lili , Zan Gaohui , Liu Chaoqun , Xu Xia , Li Longman , Chen Xing , Zhang Zhiyong , Yang Xiaobo 
Published: January 2022

Background
Individuals of the same chronological age may exhibit diverse susceptibilities to death. However, few studies have investigated the associations between blood pressure and the accelerated aging.

Methods and Results

A cross‐sectional study was conducted in 288 adults aged ≥50 years. We assessed the DNA methylation‐based measures of biological age using CpG sites on the Illumina HumanMethylationEPIC BeadChip. Epigenetic age acceleration metrics were derived by regressing residuals (ΔAge) and ratios (aging rate) of DNA methylation age on chronological age. Dose‐response relationships between blood pressure and epigenetic age acceleration were quantified using multiple linear regression and restricted cubic regression models. We found that each 10–mm Hg increase in systolic blood pressure was associated with 0.608 (95% CI, 0.231–0.984) years increase in ΔAge and 0.007 (95% CI, 0.002–0.012) increase in aging rate; meanwhile, for pulse pressure, the increase was 1.12 (95% CI, 0.625–1.61) years for ΔAge and 0.013 (95% CI, 0.007–0.020) for aging rate. Subgroup analysis showed that the significant associations of systolic blood pressure and pulse pressure with epigenetic age acceleration appeared to be limited to women, although interactions between blood pressure and sex were not significant (
P
values for interaction >0.05). The combination of women and hypertension was associated with a much higher increase in ΔAge (β [95% CI], 4.05 [1.07–7.02]) and aging rate (β [95% CI], 0.047 [0.008–0.087]), compared with male participants without hypertension.

Conclusions
Our findings suggested that high systolic blood pressure and pulse pressure were associated with the epigenetic age acceleration, providing important clues for relationships between blood pressure and epigenetic aging.
Dóra Maurer: Proportions & Timing
Authors: Gabrí Carla 
Published: January 2022

Abstract
This paper aims at re-evaluating two of Hungarian artist Dóra Mauer’s films, the video work Proportions (1979) and the 16mm film Timing (1973/80). Both films follow a rigid structure. In Proportions, Maurer uses a paper roll to compare her own body measures repeatedly; in Timing, she repeatedly folds a white linen to compare the rhythm of her arm movements. Through her use of paper and the gesture of folding, the two films can be read as references to the very origin of the term format, as coined in early letterpress printing. When the notion of format is understood as a determination of a ratio and, as such, as an indexical reference to given social relationships (Summers, 2003), these films unfold sociocultural and political meanings. The present paper traces this spectrum of meaning through the pointed inclusion of historical discourses surrounding early motion studies, the art scene in socialist Hungary in the 1970s, and early time experiments before the advent of precision clocks.
Longitudinal assessment of disability amongst patients of bipolar and unipolar depressive disorders presenting to a tertiary care center in North India
Authors: Sagar Rajesh , Sen Mahadev Singh , Kumar Nand , Chawla Nishtha 
Published: January 2022

Objectives: To assess and compare the changes in disability scores associated with Bipolar Depression (BD) and Unipolar Depression (UD) over 1 year. Methods: A longitudinal study was taken up in adults diagnosed with unipolar or bipolar depressive disorder with current depressive episode. Diagnosis was made according to Schedule for Clinical Assessment in Neuropsychiatry. Severity scoring was done using Hamilton’s Depression (HAM-D) rating scale and Hamilton’s Anxiety (HAM-A) rating scale. Disability was assessed using Indian Disability Evaluation and Assessment Scale (IDEAS) and London handicap Scale (LHS) at baseline, 6 and 12 months. Results: Sixty participants were recruited (42 UD and 18 BD). No significant differences were seen in socio-demographic parameters, except higher education levels and males being overrepresented in UD. Significant differences at baseline were seen in HAM-D ( p = .001) and HAM-A ( p = .003) scores. The extent of disability was seen to correlate with severity of illness only in case of BD at baseline. No significant differences were seen in the IDEAS scores at baseline. IDEAS score improved at each follow-up assessment ( p < .001). LHS showed significant improvement over time in UD ( p < .001), but not BD ( p = .076). Percentage individuals meeting cut-off for benchmark disability (>40%) were comparable at baseline but were significantly more in the BD at 12-months ( p = .049). Conclusion and implications: Disability in psychiatry occurs equally amongst unipolar and bipolar depressive disorders and tends to improve over time, although the level of improvement may differ. It may not always correspond to severity of illness. These factors should be considered while certifying disability.
Adaptive obstacle climbing and hydrodynamic performance analyses of the amphibious robot with wheels and flexible undulating fins
Authors: Yin Qian , Xia Minghai , Luo Zirong , Shang Jianzhong 
Published: January 2022

In this paper, an amphibious robot with flexible undulating fins and self-adaptive climbing wheels are proposed for satisfying the needs of industrial applications. The structure of the climbing mechanism and undulating fin are firstly designed. Then, the adaptive obstacle climbing and the hydrodynamic characteristics are investigated through numerical simulations by using the Adams and Fluent, respectively. Finally, the experimental measurements of the land walking and underwater propulsion are studied. The numerical results illustrate that the amphibious robot could climb the vertical obstacle adaptively. In the underwater marching pattern, the underwater velocity could reach 1 m/s. In the rotating and yawing patterns, the angular velocity increases to the certain value while the rotating angle keeps increasing. The robot moves forward and turns around with the difference frequency of the undulating fins. The underwater propulsion and land-walking experiments show good swimming performance and the obstacle crossing ability of the amphibious robot, respectively, which verify the numerical simulation.
Aripiprazole in young people with early psychosis: a systematic review and meta-analysis of weight gain
Authors: Parmar Arti , Hulme Donald , Hacking Daniel , Shymko Gordon , Dragovic Milan , Terina Grace , Waters Flavie 
Published: January 2022

Objective: Aripiprazole is often prescribed to young people, although there remain unanswered questions about its effects on weight gain. This study undertook a meta-analysis of weight gain occurring in young people with early psychosis who were prescribed aripiprazole. Method: A systematic search was conducted for studies reporting on aripiprazole and weight change in young people with a psychotic disorder. A meta-analysis integrated the data into an estimate of effect size. Results: Eleven studies met the inclusion criteria amounting to 886 participants (mean age 18 years). The results showed significant weight gain averaging 2.7 kg. These increases were associated with a longer duration of exposure to aripiprazole but not a higher dosage. Conclusions: The results highlight the importance of regular patient monitoring and the early implementation of interventions to manage antipsychotic-related weight gain.
The Role of Education in Breast Cancer Beliefs and Screening Practices Among Korean Women – A quantitative study
Authors: Kwok Cannas , Lee Mi-Joung , Lee Chun Fan 
Published: January 2022

Introduction: Cultural beliefs are influential factors that affect breast cancer screening practices among Korean women. The aim of this study was to examine the role of educational levels and compare the cultural beliefs associated with breast cancer screening practices among immigrant Korean women in Australia with those of their counterparts in Korea. Methods: A secondary analysis based on data from convenience samples of 245 and 249 Korean women living in Australia and Korea, respectively. Data were collected by the Korean version of Breast Cancer Screening Beliefs Questionnaire. Results: Educational level has a significant association with Korean women’s cultural beliefs about breast cancer and breast cancer screening practices regardless of country of residence. Discussion: Nurses working in multicultural societies should take cultural beliefs and the role of education into account while designing strategies to promote breast cancer screening practices among immigrant Korean women.
Sero-Prevalence of HBV and its Associated Factors Among Healthcare Providers in Public Health Facilities in Eastern Ethiopia
Authors: Abate Degu , Tolera Abebe , Hawulte Behailu , Tesfa Tewodros , Geleto Ayele 
Published: January 2022

Background: Healthcare providers are in high occupational risk of Hepatitis B virus infection than that of the general population because of the high risk of occupational exposure to patients’ body fluids and accidental sharp injuries. There are no large facility-based studies conducted on the prevalence of HBV infection and its associated factors among health care providers in eastern Ethiopia. Objective: This study aimed at investigating the seroprevalence of Hepatitis B Virus and its associated factors among the healthcare providers in public health facilities in eastern Ethiopia. Methods: A facility-based cross-sectional study was conducted among 438 randomly selected healthcare providers in eastern Ethiopia from March to June 2018. Pretested structured questionnaire was used to collect data on socio-demographic characteristics and other risk factors. In addition, a 2.5 ml blood was collected and the serum was analyzed for Hepatitis B surface antigen using the Instant Hepatitis B surface antigen kit. Data were entered using Epidata version 3.1 and analyzed using SPSS statistical packages version 22. Descriptive summary measures were used. Bivariate and multivariable logistic regression was conducted at 95% CI. An association at P-value <.05 was considered statistically significant. Results: A total of 438 (92.02% response rate) health care providers have participated in this study. The prevalence of hepatitis B virus infection was 9.6%. There were no significant differences in the HBV infection rates among healthcare providers with respect to socio-demographic characteristics ( P-value >.05). After adjusting for some variables, the following variables remained statistically significantly associated with HBsAg positive result in the multivariable analysis: exposure to body fluids (AOR = 3.0; 95% CI [1.25, 7.05]), history of needle stick injury (AOR = 4.70; 95% CI [2.10, 10.55]), history of operation/surgery (AOR = 4.88, 95% CI [1.43, 16.62]), history of multiple sexual partner (AOR = 7.48; 95% CI [2.08, 26.96]), and being unvaccinated (AOR = 6.09; 95% CI [2.75, 13.51]). Conclusion: This study showed a high prevalence of HBV infection among health care providers in eastern Ethiopia. This is significant because health professionals may be at increased risk of chronic complications and may also be source of infection for their clients and general population during their healthcare practice. Management commitment that should focus on occupational safety and health promotions is necessary.