bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mismatched perfusion defects on routine ventilation‐perfusion scans after lung transplantation
Authors: Li David , Abele Jonathan , Sunner Parveen , Varughese Rhea , Hirji Alim , Weinkauf Justin , Nagendran Jayan , Lien Dale , Halloran Kieran 
Published: March 2022

AbstractBackgroundIncidental pulmonary embolism (PE) is a challenging entity with unclear treatment implications. Our program performs routine ventilation‐perfusion (VQ) scans at 3‐months post‐transplant to establish airway and vascular function. We sought to determine the prevalence and prognostic implications of mismatched perfusion defects (MMPD) found on these studies, hypothesizing they would be associated with a benign prognosis.MethodsWe studied VQ scans obtained routinely at 3‐months post‐transplant from double lung transplant recipients 2005–2016 for studies with MMPD interpreted as high or intermediate probability for PE. We tested the relationship between MMPD and 1‐year survival via chi square testing, overall survival via Kaplan Meier analysis with log rank testing and peak forced expiratory volume in 1 second (FEV1) percent predicted via t‐testing.ResultsThree hundred and seventy‐three patients met inclusion criteria, of whom 35 (9%) had VQ scans with MMPDs interpreted by radiologists as high or intermediate probability for PE. Baseline recipient and donor characteristics were similar between groups. Seven patients (20%) in the MMPD group were treated with therapeutic anticoagulation. Patients with MMPD had similar 1‐year survival (100% vs. 98%, P = 1.00), overall survival (log rank P = .90) and peak FEV1% predicted (94% [SD 20%] vs. 92% [SD 21%]; P = .58). Anticoagulation did not affect these relationships.ConclusionMismatched perfusion defects on routine post‐transplant VQ scan were not associated with a difference in survival or lung function. A conservative approach to these changes may be a viable option in the absence of other anticoagulation indications.
Parental smoking, type 1 diabetes, and islet autoantibody positivity in the offspring: A systematic review and meta‐analysis
Authors: Edstorp Jessica , Lampousi Anna‐Maria , Carlsson Sofia 
Published: March 2022

AbstractAimsOur aim was to synthesize current evidence on the association between parental smoking and incidence of type 1 diabetes and islet autoantibody positivity (IA) in the offspring by conducting a systematic review and meta‐analysis.MethodsWe searched Medline, Embase, and Cochrane Library until January 21, 2021, for human studies with parental tobacco use as exposure, type 1 diabetes or IA as outcome, and hazard, risk, or odds ratios as effect estimates. Summary relative risks (RR) and 95% confidence intervals (CI) were estimated with random‐effects models. Heterogeneity was quantified with the I2 statistic, bias with the ROBINS‐I tool, and the certainty of evidence with the GRADE tool.ResultsWe identified 535 records of which 23 were eligible including 25 927 cases of type 1 diabetes. Maternal smoking during pregnancy was associated with a reduced risk of type 1 diabetes (n = 22, RR 0.78, CI 0.71–0.86,I2=69%). Including only studies with low to moderate risk of bias indicated similar results with less heterogeneity (n = 14, RR 0.73, CI 0.68–0.79,I2 = 44%). The certainty of evidence was graded as high. There was no clear association between type 1 diabetes and neither maternal (n = 6, RR 0.95, CI 0.78–1.14,I2 = 0%) nor paternal (n = 6, RR 0.90, 0.70–1.17,I2 = 68%) smoking during childhood. Furthermore, the association between maternal smoking during pregnancy and IA was weak (n = 4, RR 0.86, CI 0.44–1.65,I2 = 71%).ConclusionsMaternal smoking during pregnancy may reduce the risk of type 1 diabetes in the offspring. Further studies are needed to elucidate potential mechanisms underlying this association.RegistrationProspero CRD42021236717.
A Transitional Conception of Modernity for Education
Authors: Zrudlo Ilya 
Published: March 2022

AbstractIn this article, Ilya Zrudlo unpacks the educationally limiting effects of conflicting visions of the good embedded in Western modernity and offers a developmental vision of modernity for education that is more coherent and productive of student agency. Drawing on Charles Taylor's work, Zrudlo disarticulates four aspects of Western modernity — economic modernization, the struggle for justice, individualism, and naturalism — and highlights the internal contradictions to which they give rise that limit student agency. Harry Brighouse's On Education is then examined in order to illustrate how one influential account attempts to bring together the different educational goods of Western modernity. Despite its strengths, Brighouse's account struggles to comprehensively integrate the different goods of Western modernity and also implies a claim to historical finality, both of which hamper student agency. To overcome these obstacles, Zrudlo suggests that we distinguish between Western modernity and modernity tout court, and that the latter can be conceived of as a period of transition, akin by analogy to a period of adolescence moving toward maturity. The purpose of education from this developmental perspective would be to foster in students the kind of agency required to transition toward maturity as individuals, as well as to contribute to a movement toward maturity at the collective level, in their own communities. Drawing on the work of Lewis Mumford, Zrudlo suggests that individuals on their way to maturity strive to comprehensively and coherently develop their capacities to contribute the greater share of their powers to the development of diverse and unified communities that are organically integrated into a new, global civilization.
Tree species diversity increases with conspecific negative density dependence across an elevation gradient
Authors: LaManna Joseph A. , Jones F. Andrew , Bell David M. , Pabst Robert J. , Shaw David C. 
Published: March 2022

AbstractElevational and latitudinal gradients in species diversity may be mediated by biotic interactions that cause density‐dependent effects of conspecifics on survival or growth to differ from effects of heterospecifics (i.e. conspecific density dependence), but limited evidence exists to support this. We tested the hypothesis that conspecific density dependence varies with elevation using over 40 years of data on tree survival and growth from 23 old‐growth temperate forest stands across a 1,000‐m elevation gradient. We found that conspecific‐density‐dependent effects on survival of small‐to‐intermediate‐sized focal trees were negative in lower elevation, higher diversity forest stands typically characterised by warmer temperatures and greater relative humidity. Conspecific‐density‐dependent effects on survival were less negative in higher elevation stands and ridges than in lower elevation stands and valley bottoms for small‐to‐intermediate‐sized trees, but were neutral for larger trees across elevations. Conspecific‐density‐dependent effects on growth were negative across all tree size classes and elevations. These findings reveal fundamental differences in biotic interactions that may contribute to relationships between species diversity, elevation and climate.
Absence of myofibrillar myopathy in Quarter Horses with a histopathological diagnosis of type 2 polysaccharide storage myopathy and lack of association with commercial genetic tests
Authors: Valberg Stephanie J. , Henry Marisa L. , Herrick Keely L. , Velez‐Irizarry Deborah , Finno Carrie J. , Petersen Jessica L. 
Published: March 2022

AbstractBackgroundGenetic tests for variants in MYOT (P2; rs1138656462), FLNC (P3a; rs1139799323 or P3b; rs1142918816) and MYOZ3 (P4; rs1142544043) genes are offered commercially to diagnose myofibrillar myopathy (MFM) and type 2 polysaccharide storage myopathy (PSSM2) in Quarter Horses (QH).ObjectivesTo determine if PSSM2‐QH has histopathological features of MFM. To compare genotype and allele frequencies of variants P2, P3, P4 between control‐QH and PSSM2‐QH diagnosed by histopathology.Study designRetrospective cross‐sectional.MethodsThe study includes a total of 229 healthy control‐QH, 163 PSSM2‐QH GYS1 mutation negative. Desmin stains of gluteal/semimembranosus muscle were evaluated. Purported disease alleles P2, P3a, P3b, P4 were genotyped by pyrosequencing. Genotype, allele frequency and total number of variant alleles or loci were compared between phenotypes using additive/genotypic and dominant models and quantitative effects evaluated by multivariable logistic regression.ResultsHistopathological features of MFM were absent in all QH. A P variant allele at any locus was not associated (P > .05) with a histopathological diagnosis of PSSM2 and one or more P variants were common in control‐QH (57%) and PSSM2‐QH (61%). Allele frequencies (control/PSSM2) were: 0.24/0.21 (P2), 0.07/0.12 (P3a), 0.07/0.11 (P3b) and 0.06/0.08 (P4). P3a and P3b loci were not independent (r2 = 0.894); and not associated with PSSM2 histopathology comparing the haplotype of both P3a and P3b variants to other haplotypes. A receiver operator curve did not accurately predict the PSSM2 phenotype (AUC = 0.67, 95% CI 0.62‐0.72), and there was no difference in the total number of variant loci or total variant allele count between control‐QH and PSSM2‐QH.Main limitationsP3a and P3b were not in complete linkage disequilibrium.ConclusionsThe P2, P3 and P4 variants in genes associated with human MFM were not associated with PSSM2 in 392 QH. Their use would improperly diagnose PSSM2/MFM in 57% of healthy QH and fail to diagnose PSSM2 in 40% of QH with histopathological evidence of PSSM2.
Lessons for a COVID‐19 era: Barriers and facilitators to court ordered online parenting programs for divorcing and separating parents
Authors: Tomlinson Claire S. , Rudd Brittany N. , Applegate Amy G. , Diaz Anjolii , Holtzworth‐Munroe Amy 
Published: March 2022

AbstractFamily courts are increasingly interested in online parenting programs for divorcing and separating parents, particularly during the COVID‐19 pandemic. To our knowledge, no previous study has evaluated the barriers to and facilitators of parent participation in these programs for family law cases. We interviewed 61 parents in the midst of family law cases regarding their perspectives. While many parents viewed online parent programs positively (e.g., convenient), they also reported barriers to participation (e.g., technology problems). We offer recommendations (e.g., communication about program benefits) to support courts as they decide whether to continue ordering online parent programs following the pandemic.
Marine‐climate interactions with the blue shark (Prionace glauca) catches in the western coast of Baja California Peninsula, Mexico
Authors: Godínez‐Padilla Carlos Javier , Castillo‐Géniz José Leonardo , Hernández de la Torre Benigno , González‐Ania Luis Vicente , Román‐Verdesoto Marlon H. 
Published: March 2022

AbstractFishery and size data by sex of 28,110 blue sharks (Prionace glauca) from 2162 longline sets documented by observers on board 204 fishery trips from the industrial fleet based in Ensenada, Mexico during 2006–2016, were used to conduct a spatial–temporal analysis of the catch‐per‐unit‐effort (CPUE) and its relationship with climate indices along the west coast of the Baja California Peninsula. Catch length analysis by maturity groups indicated catches were composed mainly by juvenile females (58–199 cm TL) and males (60–179 cm TL). Relationships of seasonal CPUE with sea surface temperature (SST) and Chlorophyll‐a (Chl) were analyzed determining aggregations were in areas characterized by oceanographic physical processes. From the exploratory analysis of annual correlations of climate indices with CPUE, the local climate SanDiAs Index explained most variation in CPUE. A generalized additive model (GAM) with 13 predictor variables was applied to gain insight on their relationship with the total CPUE by size and sex groups. The model explained 50.5% of the total blue shark CPUE and 65.5% for juvenile females. The GAM results revealed blue shark CPUE is influenced by five relevant factors: SST, NPGO, year, latitude with distance to coast and quarter interactions, and hooks set. There is a trend to increase or decrease of CPUE when compared with the delay of NEI and SanDiAs indices in more than 1 year. Local and regional climate indices can be successful tools for forecasting blue shark catches in the Northwestern Mexican Pacific.
Mapping the socially responsible consumption gap research: Review and future research agenda
Authors: Falcão Diana , Roseira Catarina 
Published: March 2022

AbstractThis paper provides a wide‐ranging view of the literature that is relevant to study the gaps in socially responsible consumption (SRC). The research design follows a three‐stage analytical procedure. First, we critically review the main concepts and vocabularies used in the field and propose a framework that organizes existing studies into four major types according to their approaches and focus: gap prediction, willingness ‘to go responsible’, gap understanding and barriers to SRC. Second, a qualitative content analysis provided a set of words and semantic categories for text searches in bibliographic databases. Findings showed that the Anglo‐Saxon countries lead the field, and that patterns are changing, such as the rise of China as a contributor. Finally, a bibliometric analysis of 3,367 articles, retrieved from the Scopus and Web of Science databases, identified the intellectual structure of the SRC gap literature, top contributors (countries, publications and authors), mature and emerging themes and the main barriers to SRC adoption. The 25 top journals published almost 50% of the articles and citations. TheInternational Journal of Consumer Studies (IJCS) stands out as the only journal focused on consumer behaviour among the most prolific publications in the SRC gap literature. This finding makes theIJCSthe benchmark for researchers in the field. The SRC gap research addresses five domains: clean energy, biodiversity, public safety, food‐related issues and consumer marketing research. These domains share six reasons for the SRC gaps: economic and financial factors, information and knowledge barriers, sense of effort, lack of feelings of responsibility, contextual and social factors and supply aspects. Overall, this study provides clarity into the relevant literature that helps the SRC gaps’ understanding and identifies directions for future research.
Structural characterisation, gastrointestinal digestion stability and transepithelial transport study of casein peptide–zinc chelate
Authors: Wang Bo , Xiao Shan , Chen Xiangyu , Wang Jihui 
Published: March 2022

SummaryIn this study, a promising nanoparticle of casein peptide–zinc chelate (CNP‐Zn) for zinc supplementation was obtained. The structure properties and transepithelial transport mechanism were investigated. The amino acid composition, particle size, zeta potential and microstructure were significantly changed after chelation with zinc ions. The results of fourier‐transform infrared spectroscopy suggested that the oxygen atoms from both the carboxyl and carbonyl groups, amides, were responsible for zinc chelation. After gastrointestinal digestion, over 40% of zinc remained bound in CNP–Zn. The transepithelial transport results showed that paracellular route and PepT1 transporter were involved in the absorption of CNP–Zn, and almost 50% of the bound zinc was co‐transported with peptides. These findings would provide a relatively comprehensive cognition for developing efficient dietary zinc carriers.
Insights from proteome to phosphorylated proteome: deciphering different regulatory mechanisms in goat muscles with high‐ and low‐meat quality
Authors: Gu Minghui , Wei Yanchao , Jiao Yang , Zhang Dequan , Liu Yongfeng 
Published: March 2022

SUMMARYTo investigate the inner mechanisms of meat quality differences between high‐quality (HQ) and low‐quality (LQ), a comparative quantitative study between longissimus thoracis and external intercostals of goat muscle was performed from proteome to phosphorylated proteome using RP‐HPLC in combination with the ‘isobaric tag’ for relative and absolute quantitation (iTRAQ) labelling strategy. Altogether, 1441 proteins were identified in our study, of which 673 were phosphoproteins, and a total of twenty were common differentially expressed proteins. Myosin, carbonic anhydrase, and phosphoglucomutase could be used as proteins marker for HQ and LQ meat. Bioinformatics analysis showed that these proteins exhibited different rates for glycolysis and oxidative phosphorylation reaction, thus causing the different pH and NADH change rates, and resulting in better colour, tenderness, and water retention in HQ meat. The release of Ca2+ and adenosine triphosphate changed the meat quality through calcium signalling. Our finding provides a comprehensive view of proteome changes and their phosphorylation levels in goat muscle, involved in producing meats of different muscle parts. It also gives a better understanding of the regulation of protein on various biological processes that determine the final meat quality attributes.
Takotsubo syndrome in New Zealand: current knowledge and future challenges
Authors: Looi Jen‐Li , Chan Christina , Bridgman Paul , Kerr Andrew J. 
Published: March 2022

AbstractTakotsubo syndrome (TS), also known as apical ballooning syndrome, is a transient stress‐related cardiomyopathy characterised by acute but reversible left ventricular dysfunction. The condition tends to occur in postmenopausal women after a stressful event. At presentation, TS typically mimics acute myocardial infarction (MI) and the incidence of TS has been increasing worldwide. This is likely a consequence of an improved awareness of the existence of this syndrome and easier access to early echocardiography and coronary angiography. However, its aetiology remains poorly understood and it is probably still underdiagnosed. Similar to other countries, TS is being increasingly recognised in New Zealand. In this review, we discuss the demographics, clinical features and outcomes of patients with TS in New Zealand. Doing so informs us not only of the pattern of disease in New Zealand but it also provides insights into the condition itself.
Vaccine literacy: A concept analysis
Authors: Badua Avie Rotsen , Caraquel Krystelle Joy , Cruz Marjorie , Narvaez Roison Andro 
Published: March 2022

AbstractThe 2019 Coronavirus Disease (COVID‐19) is dubbed as one of the deadliest and worst global pandemics. Many pandemic policies and programs were implemented in different countries across the globe, including the creation of vaccines that would enhance human immunity against the symptoms caused by the virus. Since then, debates on vaccines have emerged, citing vaccine hesitancy often associated with certain factors like socioeconomic status, beliefs, and vaccine awareness. This birthed to an intensive call for vaccine literacy as an effective means of encouraging people to get vaccinated against viruses. This paper uses the Walker and Avant’s (2019, Strategies for theory construction in nursing, 6th edn. New York, NY: Pearson) approach of concept analysis with the help of its eight systematic stages. Results showed that vaccine literacy was adopted after the concept of health literacy. It is defined as a process of providing vaccine information, building communication, and increasing people's engagement about vaccines. The identified defining attributes of vaccine literacy include ‘health literacy’, ‘disease prevention’, ‘education’, and ‘immunization’. Vaccine literacy is considered relevant in the nursing practice as knowledge on vaccine literacy easily advances nurses' practice roles through vaccination education, creating developmental policies about vaccines, and prescribing immunization to patients.
Research Review: The effect of school‐based suicide prevention on suicidal ideation and suicide attempts and the role of intervention and contextual factors among adolescents: a meta‐analysis and meta‐regression
Authors: Walsh Eibhlin H. , McMahon Jennifer , Herring Matthew P. 
Published: March 2022

BackgroundGlobally, suicide is the fourth highest cause of adolescent mortality (Suicide: https://www.who.int/news‐room/fact‐sheets/detail/suicide). The effects of post‐primary school‐based suicide prevention (PSSP) on adolescent suicidal thoughts and behaviours (STBs) have not been comprehensively synthesised. We aim to estimate the population effect for PSSP interventions on adolescent STBs and explore how intervention effects vary based on intervention and contextual moderators.MethodsSearches of PsycINFO, Medline, Education Source, ERIC, Web of Science, and the Cochrane Central Register of Controlled Trials identified cluster randomised trials examining the effectiveness of PSSP on adolescent STBs. The Cochrane Risk of Bias tool assessed bias. Crude and adjusted back‐transformed odds ratios (ORs) were calculated. Multilevel random‐effects models accounted for dependencies of effects. Univariate meta‐regression explored variability of intervention and contextual moderators on pooled effects.ResultsThere were 19 and 12 effects for suicidal ideation (SI) and suicide attempts (SA). Compared with controls, interventions were associated with 13% (OR = 0.87, 95%CI [0.78, 0.96]) and 34% (OR = 0.66, 95%CI [0.47, 0.91]) lower crude odds reductions for SI and SA, respectively. Effects were similar for adjusted SI (OR = 0.85, 95%CI [0.75, 0.95]) and SA (OR = 0.72, 95%CI [0.59, 0.87]) models. Within‐study (0.20–9.10%) and between‐study (0–51.20%) heterogeneity ranged for crude and adjusted SA models and SI heterogeneity was 0%. Moderator analyses did not vary SA effects (ps > .05).ConclusionsThis meta‐analysis contributes to the PSSP evidence‐base by demonstrating that PSSP targeting STBs as both primary intervention outcomes and with other health and well‐being outcomes reduced SI and SA among 33,155 adolescents attending 329 schools, compared to controls. The number needed to treat estimates suggests the potential of reducing the incidence of SA and SI in one adolescent by implementing PSSP in 1–2 classrooms, supporting PSSP as a clinically relevant suicide prevention strategy. Although moderator analyses were nonsignificant and contained a small number of trials, larger SA effect sizes support particular effectiveness for interventions of a duration of ≤1 week, involving multiple stakeholders and with a 12‐month follow‐up.
Environment dependence of the expression of mutational load and species’ range limits
Authors: Perrier Antoine , Sánchez‐Castro Darío , Willi Yvonne 
Published: March 2022

AbstractTheoretical and empirical research on the causes of species’ range limits suggest the contribution of several intrinsic and extrinsic factors, with potentially complex interactions among them. An intrinsic factor proposed by recent theory is mutational load increasing towards range edges because of genetic drift. Furthermore, environmental quality may decline towards range edges and enhance the expression of load. Here, we tested whether the expression of mutational load associated with range limits in the North American plant Arabidopsis lyrata was enhanced under stressful environmental conditions by comparing the performance of within‐ versus between‐population crosses at common garden sites across the species’ distribution and beyond. Heterosis, reflecting the expression of load, increased with heightened estimates of genomic load and with environmental stress caused by warming, but the interaction was not significant. We conclude that range‐edge populations suffer from a twofold genetic Allee effect caused by increased mutational load and stress‐dependent load linked to general heterozygote deficiency, but there is no synergistic effect between them.