bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time to non-adherence to iron and folic acid supplementation and associated factors among pregnant women in Hosanna town, South Ethiopia: Cox-proportional hazard model
Authors: Bancha Belay , Lajore Bereket Abrham , Petros Legese , Hassen Habtamu , Jemal Admasu 
Published: September 2022

Backgrounds
Micronutrient deficits in women of reproductive age have been linked to poor pregnancy outcomes. The most common micronutrient deficits in women are iron and folate. The World Health Organization recommends daily oral iron and folic acid supplementation (IFAS) as part of routine antenatal care to lower the risk of maternal anemia and adverse pregnancy outcomes. However, the effectiveness of the supplementation relies on client’s strict adherence. The aim of this study was to determine time- to- non-adherence to IFAS and associated factors among pregnant women in Hosanna Town, South Ethiopia.

Methods
A community based cross sectional study design was employed from May 15-June11, 2021. Data were entered into Epi-Data version 3.1 and exported to SPSS version 23 for analysis. The Cox regression hazard model was applied. The threshold of statistical significance was declared at a p-value <0.05 and adjusted hazard ratios (AHRs) with corresponding 95% confidence intervals were used to report.

Result
The median time-to-non-adherence was 74 days (95 percent CI: 65.33–82.67). After adjusting for the confounders, age (AHR = 1.05, 95% CI: 1.01–1.09), education status (AHR = 2.43 95%CI 1.34–4.40, AHR 3.00, 95% CI: 2.09–4.31, AHR 1.91, 95% CI: 1.32–2.77), household’s wealth index (AHR = 1.73, 95% CI: 1.19–2.51, AHR = 1.64, 95% CI:1.15–2.35), and counseling at service delivery (AHR = 2.53, 95% CI: 1.88–3.41) were independent predictors of time to non-adherence to IFAS among pregnant women.

Conclusion
The median time to non-adherence was short and women became non-adherent before the recommended duration. Improving women’s education and counseling pregnant women on IFAS during pregnancy would make a change.
Clinical Prediction Models for Pancreatic Cancer in General and At-Risk Populations: A Systematic Review
Authors: Santos Ralph , Coleman Helen G. , Cairnduff Victoria , Kunzmann Andrew T. 
Published: September 2022

INTRODUCTION:
Identifying high-risk individuals using a risk prediction model could be a crucial first stage of screening pathways to improve the early detection of pancreatic cancer. A systematic review was conducted to critically evaluate the published primary literature on the development or validation of clinical risk prediction models for pancreatic cancer risk.

METHODS:
MEDLINE, Embase, and Web of Science were searched for relevant articles from the inception of each database up to November 2021. Study selection and data extraction were conducted by 2 independent reviewers. The Prediction model Risk Of Bias Assessment Tool (PROBAST) was applied to assess risk of bias.

RESULTS:
In total, 33 studies were included, describing 38 risk prediction models. Excluding studies with an overlapping population, this study consist of 15,848,100 participants, of which 58,313 were diagnosed with pancreatic cancer. Eight studies externally validated their model, and 13 performed internal validation. The studies described risk prediction models for pancreatic cancer in the general population (n = 14), patients with diabetes (n = 8), and individuals with gastrointestinal (and other) symptoms (symptoms included abdominal pain, unexplained weight loss, jaundice, and change in bowel habits and indigestion; n = 11). The commonly used clinical risk factors in the model were cigarette smoking (n = 27), age (n = 25), diabetes history (n = 22), chronic pancreatitis (n = 18), and body mass index (n = 14). In the 25 studies that assessed model performance, C-statistics ranged from 0.61 to 0.98. Of the 33 studies included, 6 were rated as being at a low risk of bias based on PROBAST.

DISCUSSION:
Many clinical risk prediction models for pancreatic cancer had been developed for different target populations. Although low risk-of-bias studies were identified, these require external validation and implementation studies to ensure that these will benefit clinical decision making.
Sleep Disturbances, Bowel Movement Kinetics, and Travel Interruption With Bowel Preparation: A Bowel CLEANsing National Initiative Substudy
Authors: Tse Carmen , Barkun Alan , Martel Myriam , Nugent Zoann , Epstein Ian , Sey Michael , Richard Sultanian , von Renteln Daniel , Singh Harminder 
Published: September 2022

INTRODUCTION:
We investigated sleep disturbances, bowel movement (BM) kinetics, and travel experience with different bowel preparation regimens in a substudy of patients enrolled in a randomized multicenter Canadian clinical trial.

METHODS:
Patients scheduled to have a colonoscopy between 7:30 am and 10:30 am (early morning) were randomized to (i) 4-L single-dose polyethylene glycol (PEG) given in the evening before, (ii) 2-L split-dose PEG (+bisacodyl 15 mg), or (iii) 4-L split-dose PEG. Patients scheduled to undergo a colonoscopy between 10:30 am and 4:30 pm (afternoon) were randomized to (iv) 2-L single-dose PEG (+bisacodyl 15 mg) in the morning, (v) 2-L split-dose PEG (+bisacodyl 15 mg), or (vi) 4-L split-dose PEG. Patients were asked to record information on BM kinetics, sleep, and travel to the endoscopy unit. Continuous and categorical variables were compared between groups using a Kruskal-Wallis test or χ2 test, respectively. Intention-to-treat analyses were performed.

RESULTS:
Overall, 641 patients were included in this substudy. Patients undergoing early morning colonoscopies reported the most awakenings in the night when assigned to 4-L single-dose day-before PEG and the highest reduction in sleep hours when assigned to 4-L split-dose PEG. There were no significant between-group differences in urgent BMs, fecal incontinence episodes, or travel interruptions. Overall, 17% of those traveling for more than an hour had to stop for a BM during travel, with no significant difference between groups.

DISCUSSION:
Day-before and split-dose high-volume PEG regimens for colonoscopies scheduled before 10:30 am lead to the greatest sleep disturbance.
Problems in Cross-Cultural Legal Discourse: U.S. Federal and Native American Tribal Criminal Law
Authors: Brewer Janet 
Published: September 2022

Abstract
Through examination of conflict of laws as to U.S. federal courts and tribal law, this study highlights the impact of culture upon legal meaning. Disparities stem from long-standing norms which underpin legal concepts. These terms which give rise to legal philosophy and the judicial process defy clear English interpretation. Examples include the Latin term mens rea which serves as the foundation for Anglo-American punishment theory, and the Navajo term hózhó from which all conceptualizations of social order emanate. An exploration of these examples in the context of a recent case underscores the close link between law and culture.
“Mines in the Classroom”: Black student’s safety with general and special educators
Authors: Smith R. Kweku Akyierfi 
Published: September 2022

AbstractHow Black learners are made to feel in the classroom by their general and special education professionals affect how they learn and navigate their world. An historical account of American education for the Black mind can be viewed as dull, dangerous, and deadly. It is imperative that each child feels physical and psychological safety in every educational environment. This is the premise of this article.
Multifunctional croconaine nanoparticles for efficient optoacoustic imaging of deep tumors and photothermal therapy
Authors: Liu Nian , O’Connor Patrick , Gujrati Vipul , Anzenhofer Pia , Klemm Uwe , Kleigrewe Karin , Sattler Michael , Plettenburg Oliver , Ntziachristos Vasilis 
Published: September 2022

Abstract
The proper design of near-infrared light-absorbing agents enables efficient optoacoustic imaging-guided phototherapy. In particular, several croconaine-based organic agents with excellent optical properties have been recently reported for this purpose. However, most of them absorb light below 800 nm, limiting deep-tissue imaging applications. To this end, we utilized a recently described novel croconaine derivative (CR880) to develop CR880-based nanoparticles (CR880-NPs) for effective in vivo delivery, deep tissue optoacoustic imaging and photothermal therapy applications. Radicals and strong π–π stacking in CR880 result in an 880 nm absorption peak with no blue-shift upon condensing to the solid phase. DSPE-PEG2000-formulated CR880-NPs exhibited high optoacoustic generation efficiency and photostability, and could be visualized in the tumors of three different mouse tumor models (breast, brain, and colon tumor) with high image contrast. The high photothermal conversion efficiency of CR880-NPs (∼58%) subsequently enabled efficient in vivo tumor elimination using a low energy laser, while remaining biocompatible and well-tolerated. This work introduces a promising novel agent for cancer theranostics of challenging deep-seated tumors.
Crystal structure of tetrasodium-bis(μ
2-oxido)-hexafluoro-didioxo-molybdenum(V), Na2(Mo2O4F6)
Authors: Wu-Hua Chen , Zhu-Sen Zhang , Ze-Hai Qiu , Li-Ting Wen , Hong Xu 
Published: September 2022

Abstract
O4F6Na2Mo2, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 6.6154(6) Å, b = 7.8572(8) Å, c = 9.3588(11) Å, α = 95.257(9)°, β = 90.753(9)°, γ = 113.426(10)°, V = 443.83(9) Å3, Z = 2, R

gt
(F) = 0.0431, wR

ref
(F
2) = 0.1125, T = 293(2) K.
Biofuel as an alternative energy source for environmental sustainability
Authors: Ganesan Subbulakshmi , Padmapriya Gopalakrisnan , De Zoys Sanduni Anupama , Omoikhoje Izegaegbe Daniel 
Published: September 2022

Abstract
Organic carbon fixation is the primary source of biofuels energy. Plant biomass and municipal and industrial waste are used to make gasoline that is renewable and biodegradable. Biofuel could be beneficial due to the reduced dependency on fuel, to lower the reliance on overseas oil, to lower the emissions of greenhouse gases and it provides job opportunities for the rural people. Moreover, due to the very high demand for fuel, because most of the machines, vehicles use fuel to conduct day today activities. Due to this high demand, the price is also very high. Not only that, the burning of fossil fuel normally release carbon dioxide, carbon monoxide and nitrogen dioxide which are the greenhouse gases. But although biogas too releases those gases, they are released in very lower amounts. Therefore, fuel can act as a good solution for the problems that occur due to global warming and many other environmental problems.
A meta-analytical review of transcranial direct current stimulation parameters on upper limb motor learning in healthy older adults and people with Parkinson’s disease
Authors: Siew-Pin Leuk Jessie , Yow Kai-En , Zi-Xin Tan Clenyce , Hendy Ashlee M. , Kar-Wing Tan Mika , Hock-Beng Ng Tommy , Teo Wei-Peng 
Published: September 2022

Abstract
Current literature lacks consolidated evidence for the impact of stimulation parameters on the effects of transcranial direct current stimulation (tDCS) in enhancing upper limb motor learning. Hence, we aim to synthesise available methodologies and results to guide future research on the usage of tDCS on upper limb motor learning, specifically in older adults and Parkinson’s disease (PD). Thirty-two studies (Healthy older adults, N = 526, M = 67.25, SD = 4.30 years; PD, N = 216, M = 66.62, SD = 6.25 years) were included in the meta-analysis. All included studies consisted of active and sham protocols. Random effect meta-analyses were conducted for (i) subjects (healthy older adults and PD); (ii) intensity (1.0, 1.5, 2 mA); (iii) electrode montage (unilateral anodal, bilateral anodal, unilateral cathodal); (iv) stimulation site (cerebellum, frontal, motor, premotor, SMA, somatosensory); (v) protocol (online, offline). Significant tDCS effect on motor learning was reported for both populations, intensity 1.0 and 2.0 mA, unilateral anodal and cathodal stimulation, stimulation site of the motor and premotor cortex, and both online and offline protocols. Regression showed no significant relationship between tDCS effects and density. The efficacy of tDCS is also not affected by the number of sessions. However, studies that reported only single session tDCS found significant negative association between duration with motor learning outcomes. Our findings suggest that different stimulation parameters enhanced upper limb motor learning in older adults and PD. Future research should combine tDCS with neuroimaging techniques to help with optimisation of the stimulation parameters, considering the type of task and population.
Exploration des systèmes de signes dans quatre jeux sportifs : analyse comparative du football, du handball, de la balle assise et du jeu des trois camps
Authors: Oboeuf Alexandre , Collard Luc , Buffet Josephine 
Published: September 2022

Résumé
Dans les situations sociomotrices, l’engagement des participants n’est pas seulement réductible aux communications directes (impliquant un rapport à l’objet ou un corps-à-corps). Il est surtout lié à l’émergence de systèmes de signes assurant la dynamique globale du jeu. Nous proposons d’appréhender la communication comme un système d’interaction global constitué de plusieurs canaux. On y retrouve les communications directes mais aussi quatre systèmes de signes : celui des praxèmes, des gestèmes, des gestes et des communications verbales. Ce travail interroge la place de chaque canal communicationnel dans deux sports (football, handball) et deux jeux traditionnels (Balle assise et Trois camps). Nous recrutons trois groupes de 20 étudiants pour participer aux jeux mentionnés. Les communications sont filmées, décryptées, triées et catégorisées. On constate une forte prévalence des praxèmes dans les sports collectifs, tandis que la répartition des communications est plus équilibrée dans les jeux traditionnels (p < 0.01). La quantité, la variabilité et l’organisation des signes sont sensibles à la logique interne. Globalement, cette recherche tend à montrer que les jeux sont un formidable laboratoire in vivo pour comprendre l’organisation des systèmes de signes. Spécifiquement, elle apporte des informations sur le pouvoir socialisant de la sémiotricité de chaque jeu et sur le renouvellement des pédagogies qu’elle peut engendrer.
Altered Behavioral Responses Show GABA Sensitivity in Muscleblind-Like 2-Deficient Mice: Implications for CNS Symptoms in Myotonic Dystrophy
Authors: Edokpolor Kamyra S. , Banerjee Anwesha , McEachin Zachary T. , Gu Jingsheng , Kosti Adam , Arboleda Juan D. , García Paul S. , Wang Eric T. , Bassell Gary J. 
Published: September 2022

AbstractConsiderable evidence from mouse models and human postmortem brain suggests loss of Muscleblind-like protein 2 (MBNL2) function in brain is a major driver of CNS symptoms in Myotonic dystrophy type 1 (DM1). Increased hypersomnia, fatigue, and surgical complications associated with general anesthesia suggest possible sensitivity to GABAergic inhibition in DM1. To test the hypothesis that MBNL2 depletion leads to behavioral sensitivity to GABAAreceptor (GABAA-R) modulation,Mbnl2knock-out (KO) and wild-type (WT) littermates were treated with the anesthetic sevoflurane, the benzodiazepine diazepam, the imidazopyridine zolpidem, and the benzodiazepine rescue agent, flumazenil (Ro 15-1788), and assessed for various behavioral metrics.Mbnl2KO mice exhibited delayed recovery following sevoflurane, delayed emergence and recovery from zolpidem, and enhanced sleep time at baseline that was modulated by flumazenil. A significantly higher proportion ofMbnl2KO mice also loss their righting reflex [loss of righting reflex (LORR)] from a standard diazepam dose. We further examined whether MBNL2 depletion affects total GABAA-R mRNA subunit levels and validated RNA-sequencing data of mis-splicedGabrg2, whose isoform ratios are known to regulate GABA sensitivity and associated behaviors. While no other GABAA-R subunit mRNA levels tested were altered inMbnl2KO mouse prefrontal cortex,Gabrg2S/LmRNA ratio levels were significantly altered. Taken together, our findings indicate that loss of MBNL2 function affects GABAergic function in a mouse model of myotonic dystrophy (DM1).
Atom probe tomography and correlative microscopy: Key techniques for future planetary science studies
Authors: McCarroll Ingrid E. , Daly Luke , White Lee F. , Cairney Julie M. 
Published: September 2022

AbstractOur Galaxy is vast and awe-inspiring. The stars, planets, and our sun capture our imagination as children. For many of us, that wonder never ceases. It continues to inspire us throughout our careers and prompts us to question the evolution of our Solar System, to question what our place is within it, and how we may maintain longevity in a relatively volatile environment. To answer these questions planetary scientists turn to the study of extraterrestrial material. They analyze meteorites, impact craters, and materials returned by sample return missions for the evidence of events that are known to induce crystallographic and/or elemental changes, or for evidence of extraterrestrial isotopic abundances that point to the age and the original source of the material. Through these studies, we can constrain timelines of events that have occurred throughout the Solar System’s extensive history. Recently, atom probe tomography (APT) has been applied to the study of these materials. APT in correlation with larger-scale analysis techniques has provided insights into isotopic ratios or nanoscale distribution of elements, enriching our knowledge, and minimizing uncertainties in the time frame of critical cosmic events. The continued use of correlative microscopy with APT for the study of planetary science, including studies of small amounts of pristine materials delivered to the Earth by exciting sample return missions, promises to provide key information into the history of our Solar System. Here, we highlight the implications of correlative microscopy with APT for the future pursuits of planetary science, we reflect on the groundbreaking research already achieved, the challenges that have been overcome to achieve these outcomes and the challenges yet to come.
Graphical abstract
Relapse or worsening of chronic spontaneous urticaria during SARS-CoV-2 infection and vaccination in children: A telemedicine follow-up
Authors: Lascialfari Giulia , Sarti Lucrezia , Barni Simona , Liccioli Giulia , Paladini Erika , Guarnieri Valentina , Ricci Silvia , Giovannini Mattia , Mori Francesca 
Published: September 2022

Background: Chronic urticaria (CU), characterized by daily wheals and/or angioedema lasting more than 6 weeks, is a common skin disease. CU is classified as spontaneous or inducible. Because of Coronavirus Disease-19 (COVID-19) pandemic, face-to-face visits were reduced, and many centers started remote consultations to minimize hospital admissions and risk for viral diffusion. Telemedicine became a valuable tool for evaluating and monitoring patients with chronic diseases, such as CU. This study aims to evaluate the effectiveness of telemedicine as a means for the follow-up of patients with chronic spontaneous urticaria (CSU) during the COVID-19 pandemic. In particular, we collected data related to CSU evolution and treatment by remote consultation. Moreover, we specifically investigated the impact of SARS-CoV-2 infection or vaccination on CSU in relapsing or worsening of such a disease.
Methods: The electronic charts were reviewed for patients diagnosed with CSU, who were referred to the allergy unit of Meyer Children’s Hospital, Florence. For each patient, a review of demographic characteristics, diagnostic workup, efficacy, and tolerability of the treatment was performed. Patients with a physical agent triggering CU were excluded from the study. Disease activity was monitored using the Urticaria Activity Score (UAS7). In addition, when the COVID-19 pandemic started, follow-up continued through telemedicine after an initial face-to-face visit when possible. Approximately 1 year after the diagnosis of CSU, patients were recontacted to investigate whether they had experienced a relapse or worsening of urticaria during a possible COVID-19 or immediately after receiving a COVID-19 vaccine.
Results: From January 2020 to March 2021, 84 cases of CSU were identified, with 71 (84.5%) of these being evaluated via televisit (remote consultation). During the remote follow-up period, 38/71 (53.5%) patients who were evaluated via televisit recovered completely from CSU, while 24 (33.8%) made therapy adjustments, and 9 (12.7%) had to discontinue follow-up through remote visits and return to face-to-face visits. In February 2022, we recontacted the 71 patients with CSU, and 50 (70.4%) of them answered by phone call interview. Four (19.2%) of the 26 patients who had COVID-19 showed CSU relapse, while 1 (3.8%) had a CSU worsening. Instead, 1 (3.8%) patient of the 26 who were vaccinated had a relapse of CSU, and 1 (3.8%) had a worsening of CSU, both after the first dose.
Conclusion: Our data showed that telemedicine can be an effective tool for the follow-up of patients with CSU. Moreover, COVID-19, as well as COVID-19 vaccination, may trigger CSU relapse or worsening, but both are unspecific triggers, and urticaria shows a very short duration in most cases.
Distance Learning: Does it Have an Impact on the Readiness of Physical Education Teachers in Coastal Areas?
Authors: Susanto Ermawan , Mulyaningsih Farida , Mujriah Mujriah , Satriawan Rabwan , Sulfandi Sulfandi 
Published: September 2022

Study purpose. The purpose of this study was to determine whether there is an effect of distance learning on the readiness of physical education teachers in coastal areas.
Materials and methods. This study used an experimental method with one group pre-test-post-test design. The research participants were physical education teachers in junior high schools in coastal areas (n = 60). Primary data collection to measure teacher readiness was the Online Teaching Readiness Survey consisting of 41 questions with a validity level of 0.76 and a reliability of 0.91. Secondary data collection was performed using literature study.
Results. The results of the paired sample t-test showed 0.754 > 0.01, indicating the data variance was the same. By looking at the assumed equal variances, the significance result shows that .000 < .01 (confidence interval = 99%), then H0 is rejected. Based on the data, there are 10 teachers or 16% who are ready to carry out distance learning, 36 teachers or 60% are not ready, and 14 teachers or 24% are unprepared.
Conclusions. There is an impact of distance learning on the readiness of PE teachers in coastal areas. The effect in question shows the unpreparedness of PE teachers in implementing distance learning. The recommendation from the findings is that teachers need virtual learning training and adequate support to succeed in distance learning.