bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-inflammatory activity of a novel steroid isolated from Ziziphus jujube (L.) Gaertn. var Hysudrica Edgew.
Authors: Shahwar Dure-E- , Shahzadi Naureen , Butt Saba Zia , Ahmad Maqsood , Saleem Mohammad , Bukhari Nadeem Irfan , Hussain Khalid 
Published: October 2022

Abstract
Inflammation is a hallmark in autoimmune diseases and cancer. The present study was carried out to evaluate antiinflammatory potential of a novel steroid isolated from chloroform extract of stem bark of Ziziphus jujube (L.) Gaertn. Var. hysudrica Edgew. (Family: Rhmanaceae). The dried material was extracted by maceration at room temperature using methanol, acetone, ethyl acetate, dichloromethane, and chloroform. All extracts were subjected to in vitro screening studies employed to assess their anti-inflammatory activity and extract that exhibited significant biological activity was subjected to column chromatography that yielded a crystalline compound. The structure of compound was elucidated using X-ray crystallography. The isolated compound as well as most active extract were also investigated for anti-inflammatory activity using carrageenan-induced paw ooedema model. Moreover, quantitative polymerase chain reaction was also done to evaluate inhibitory action on inflammatory biomarkers. Results revealed that chloroform extract showed higher anti-inflammatory activity in all in vitro models as compared to other extracts (p ˂ 0.05). The isolated compound-2 was found to be a novel steroid and showed comparable anti-inflammatory effects with dexamethasone. In addition, downregulation in concentrations of inflammatory biomarkers (e.g., TNF-α, IL-1β, NF-κβ, and COX-2) was also noted. Histopathological analysis showed intact structure of paws in all treatment groups. On the basis of findings, it is concluded that chloroform extract of Ziziphus jujube and isolated compound-2 possess good anti-inflammatory attributes and can be developed as drug to manage inflammatory conditions in future. Furthermore, long clinical trials and efficacy studies of compound-2 are still required to be elucidated.
Prognosis and stratification of breast cancer immune infiltration status based on a mitochondria-related gene signature.
Authors: Wang yang , Wang Ding-yuan , Bu Kena , Zhang Bai-lin , Gao Ji-dong 
Published: October 2022

Abstract
Background
Tumor metabolic reprogramming has attracted extensive attention, and mitochondria play a vital role in this process as a metabolic hub. Despite increasing evidence that mitochondria are involved in breast tumorigenesis, the impact of mitochondria-related genes on breast cancer remains unclear. In this study, we aimed to construct a novel mitochondria-related gene signature through bioinformatic strategies to predict and stratify the prognosis, immune infiltration, and treatment response of breast cancer patients.
Methods
The transcriptomic data and clinical features of breast cancer samples were extracted from The Cancer Genome Atlas and Molecular Taxonomy of Breast Cancer International Consortium databases. We constructed a mitochondria-related gene signature to predict survival, and Cox regression and receiver operating characteristic were used to evaluate the overall predictive performance. Subsequently, we combined the risk scores with corresponding clinical features to construct a nomogram model and evaluated the model’s accuracy by clinical calibration curve and decision curve analysis. After dividing patients based on risk scores, several immune-related analyses were performed to compare the immune infiltration status between different groups. Finally, we compared the mutation status and drug sensitivity to explore the treatment response and underlying mechanism of the difference in prognosis.
Results
We constructed an eight mitochondria-related gene risk signature by bioinformatic strategies and verified it by Cox regression, receiver operating characteristic, calibration curve and decision curve analyses. Patients with low-risk score have a better prognosis, enhanced immune infiltration, significantly different mutation landscapes, and a more sensitive response to antitumor drugs, which may account for the favorable survival.
Conclusion
The mitochondria-related gene signature is a novel prognostic risk signature that can be used as a predictor for patient stratification in breast cancer. In addition, this signature can effectively distinguish the immune infiltration and drug sensitivity status of patients. This may provide a new perspective for the treatment of breast cancer focusing on mitochondria.
Evaluation of the Relationship Between Sphenoid Sinus Morphology and Area and Volume by Computed Tomography
Authors: Serindere Mehmet , Belgin Ceren Aktuna 
Published: October 2022

Abstract
Purpose
The aim of this retrospective study is to evaluate the relationship between sphenoid sinus volume and surface area measurements and its morphology by computed tomography (CT).
Methods
In this study, CT images of 150 patients were evaluated retrospectively. Sphenoid sinus pneumatization types, Onodi cell (OC) prevalence, protrusion and dehiscence of internal carotid artery (ICA) and optic nerve (ON) were evaluated. The volume and area of the sphenoid sinus were calculated using the manual segmentation module using InVesalius software program.
Results
Out of the 150 sinuses, 58 (38.66%), 47 (31.33%), 22 (33%), 4 (2.66%) and 8 (5.33%) were postsellar a, postsellarb,sellar type,conchal and presellar type, respectively. OC was found in 43 (28.7%) of 150 patients. ICA protrusion was observed in a total of 61 CTs (40.7%), 23 (15.3%) were unilateral and 38 (25.3%) were bilateral. Out of 61 CTs (40.7%) who showed ICA dehiscence, 51 (34.0%) were unilateral, and 10 (6.7%) were bilateral. ON protrusion was observed in a total of 43 CTs (28.7%), 14 (9.3%) were unilateral and 29 (19.3%) were bilateral. Out of 28 CTs (18.7%) who showed ON dehiscence, 17 (11.3%) were unilateral, and 11 (7.3%) were bilateral. The mean volume and area of sinus were 9949.4 ± 351.0 mm3 and 4570.9 ± 1604.9 mm2, respectively.
Conclusions
Sinus volume and area were significantly higher in patients with bilateral protrusion of ICA compared to patients without protrusion of ICA. In patients with bilateral dehiscence of ICA, sinus volume and area were found to be significantly higher than those without ICA dehiscence. Sinus volume and area were significantly higher in patients with bilateral protrusion of ON compared to patients without ON protrusion. Sinus volume and area in males were found to be significantly higher than in females.There was a negative correlation between age and sinus volume and area.Sphenoid sinuses are in different variations with the important surrounding neurovascular structures. It is important to examine these relationships in detail before the operation in order to prevent complications.
Edge emotion recognition: applying fast Fourier transform on speech Mel spectrograms to classify emotion on a Raspberry Pi for near real-time analytics
Authors: de Andrade Dominik Esteves , Buchkremer Rüdiger 
Published: October 2022

Abstract
Many people and machines are inherently unable to interpret socio-affective cues such as tone of voice. Thoughtful adoption of intelligent technologies may improve the conversation. Since direct communication often occurs via edge devices, where an additional network connection is often not guaranteed, we now describe a real-time processing method that captures and evaluates emotions in a speech via a terminal device such as the Raspberry Pi computer. In this article, we also present the current state of research on speech emotional recognition. We examine audio files from five important emotional speech databases and visualize them in situ with dB-scaled Mel spectrograms using TensorFlow and Matplotlib. Audio files are transformed using the fast Fourier transform method to generate spectrograms. For classification, a support vector machine kernel and a CNN with transfer learning are selected. The accuracy of this classification is 70% and 77%, respectively, a good value related to the execution of the algorithms on an edge device instead of on a server. On a Raspberry Pi, it took less than one second to evaluate pure emotion in speech using machine learning and the corresponding visualization, suggesting the speaker's emotional state.
Assessment of the factors associated with the performance of the National Immunization Days during Covid-19 Vaccines introduction in Cameroon
Authors: AMANI Adidja , DIA Mariette , NJOH Andreas ATEKE , GUIEDEM Elise , NDOULA Shalom , EFOUBA Gisele , MENGUE Annie , CHEUYEM Fabrice Zobel LEKEUMO , BAMA Solange NGO , TAMBASHO Afizu , NGUEFACK-TSAGUE Georges , KAMGNO Joseph , GAHONGANO Gervais 
Published: October 2022

Abstract
Introduction: Although Cameroon has been declared free of wild polio virus since 2020 by the Africa Regional Certification Commission (ARCC), in order to sustain the polio response and to continue achieving the goals of the Global Polio Eradication Initiative, the National Response Plan conducted the National Polio Immunization Days. The aim of these immunization activities was to enhance polio immunization in vulnerable populations, with the goal of increasing immunization coverage to at least 95% in children 0-59 months.
Methods: A vaccination campaign was carried out from 7-9 May 2021 throughout the country with strategies; door to door, fixed and temporary fixed points, priority transit points and markets.
Results: The target population was 6,042,816 children aged 0-59 months. Of these, 5,262,468 (87%) were vaccinated; 936,764 (75%) aged 0-11 months. Factors associated to missed vaccination were: refusal (Center: OR = 1.026; p=0.001, East: OR = 1.10; p = 0.002, Littoral: OR = 1.033; p = 0.04), Refugee status (South-west: OR = 1.022; p <0.0001, Extreme-North: OR = 1.022; p = 0.012), the nomadic status (Extreme-North: OR = 1.059; p = 0.007; West region: OR = 1.069, p < 0.0001).
Conclusion: Increasing vaccination campaigns is potent to eradicate polio virus; however, the target population must fully adhere for optimal results.
Soil Water Deficit Reduced Root Hydraulic Conductivity of common reed (Phragmites australis) by Regulating ABA-related Genes
Authors: Wang Ruiqing , Zhang Zhenming , Wang Haoyue , Chen Yinglong , Zhang Mingxiang 
Published: October 2022

Abstract
Background and Aims Root system is the main organ for absorbing water and nutrients, and the first contact to sense soil and environmental stresses. Plant root morphology and internal physiological characteristics are affected by soil moisture content, leading to differences in the rate of plant water uptake.
Methods The common reeds (Phragmites australis) were treated for 45 days at four different soil moisture content. Harvesting starts after 30 days of the treatment and the morphological characteristics, anatomical characteristics and hydraulic conductivity of the common reed root system are measured using pressure chambers and paraffin sections And common reed root transcriptomic profiles were assessed using next-generation RNA sequencing.
Results The root system shrinks morphologically and anatomically during a drought. Decrease in soil moisture significantly reduced hydraulic conductivity of both the whole and single root of the common reed. RNA-seq results implicated abscisic acid (ABA) related genes in the regulation of hydraulic conductivity, with the expression profiles of ABA1, 9-cis-epoxycarotenoid dioxygenase (NCED), ABA2, and abscisic-aldehyde oxidase 3(AAO3) showing an overall decreasing trend as drought conditions intensified. Plasma membrane intrinsic proteins (PIPs) contents varied under different soil water treatments with up-regulated expression under 60% field capacity treatment indicating that PIP genes were regulated by drought stress to some extent.
Conclusion Soil moisture contents significantly influenced root morphological, anatomical characteristics, and induced the expression of root-sourced ABA and aquaporins in common reed, which in turn altered root hydraulic conductivity.
Single-Molecule Discrimination and the Specific Binding Properties of the Lipopolysaccharides with a Solid-State Nanopore sensor
Authors: Zhu Rui , Liang Liyuan , Zheng xinchuan , Wang Zhong , Wu Ji , Qin Fupeng , Gui Xiaoyu , Fang Shaoxi , Ding Jianjun , Li Pei , Wang Deqiang 
Published: October 2022

Abstract
Lipopolysaccharides (LPS) are the major constituent on the cell envelope of all gram-negative bacteria. They are ubiquitous in water, air, and food, and are toxic inflammatory stimulators and optimal biomarkers for some urinary
disorders and sepsis. A good many optical, electrical, thermal, and electrochemical sensors based on the intermolecular interplay of LPS with proteins, peptides, and aptamers are reported, they are generally complicated methods. We demonstrate the single-molecule nanopore approach for the identification of LPS from distinct bacteria as well as the discrimination of serotypes from the same bacterium. With a 4 nm nanopore, we achieve a LOD of 10 ng/mL and a linear response up to 10,000 ng/mL. Both the antibiotic PMB and DNA aptamer display good binding affinity to LPS, and the complexes exhibit distinct nanopore translocation behaviors compared with the individual LPS. The real sample tests in both human serum and tap water show good performance characteristics in the identification of LPS in complicated media with a nanopore platforms. Our work shows a highly-sensitive and easy-to-handle scheme for clinical and environmental biomarkers determination and provides a promising screening tool for early warning of contamination in food, water, and medical supplies.
Interindividual variation of the organism - as an indicator for assessing the severity of heat stroke in an experimental study of Wistar rats
Authors: Dervisevic Emina , Dervisevic Lejla , Ajanović Zurifa , Salihbegović Adis , Mujarić Ekrema , Katica Muhamed 
Published: October 2022

Abstract
Introduction

Autopsies are often performed, but the evidence is insufficient and non-specific. The aim of the research was to determine the core temperature values of rats exposed to different water temperatures (37°C, 41°C, 44°C), before the start of the experiment (Tb), after immersion in water (Tu), after 20 minutes of exposure (Tu) and at death. (Ts) rats for the purpose of hyperthermia and heat stroke.

Material and Method

Forty rats were divided into five groups depending on the temperature and length of exposure to water: control group-CG37, G41-hyperthermia- group which exposure time was a 20 minutes on 41°C, G41-heat stroke- group exposed until death on 41°C, G44- hyperthermia- group which exposure time was a 20 minutes on 44°C, G44- heat stroke- group exposed until death on 44°C. A RET-4 probe was used to measure the core temperature of rats.

Results

Significant changes in the body temperature of rats were observed during the lethal outcome, p < 0.0005. A significant difference was also observed in postmortem temperature of groups G41 and G44, p = 0.01. a significant difference between body temperatures in groups CG37, G41-hyperthermia, G41- heat stroke, G44-hyperthermia and G44-heat stroke (p < 0.0005), and the significance of the differences in the CG37 group was p = 0.044.

Conclusion

Exposure of albino rats to different water temperatures also led to a change in the internal temperature; normothermia was established through thermoregulation in the control group, and in the other groups, hyperthermia and heat stress occurred.
Distinguishing characteristics of equiform Hasimoto surfaces in Minkowski 3-space
Authors: Mahmoud W. M. , ElHafez S. M. Abd , Solouma E. M. , Soliman M. A. 
Published: October 2022

Abstract
We investigate the equiform Hasimoto surfaces P(σ, ℓ) in Minkowski 3-space in this paper. In E 3 1 , in different three cases, the geometric properties of equiform Hasimoto surfaces are discussed. For each case, the equiform Gaussian and mean curvatures of the equiform Hasimoto surface are determined. Then, in E 3 1 , we characterize the parameter equiform Bishop curves of equiform Hasimoto surfaces. Keywords— Hasimoto surface, Minkowski geometry, equiform Bishop frame, smoke ring equation.
Predictors of antepartum maternal sepsis and effects on neonatal outcomes: a population-based cohort study
Authors: Ozarslan Nida , Gaw Stephanie , Cassidy Arianna , Caughey Aaron 
Published: October 2022

Abstract
Objective

To examine the relationship between maternal sepsis, type of infection, and short-term neonatal outcomes.

Study Design

We conducted a retrospective cohort study investigating pregnancies between 2005 and 2008 in California with antepartum maternal sepsis diagnosis. Comparisons were made between sepsis cases and all other births without sepsis, using chi-squared or Fisher’s exact test. Multivariable logistic regression (MLR) was performed, adjusting for maternal characteristics.

Results

MLR analyses indicated that specific maternal characteristics increased the odds of maternal sepsis. Chorioamnionitis, pneumonia, pyelonephritis, listeriosis, and fungal infection were all significantly associated with maternal sepsis (p < 0.001). Neonates born to patients with maternal sepsis had a higher risk of developing certain neonatal complications.

Conclusion

Maternal sepsis was associated with neonatal complications. Efforts to reduce maternal sepsis may improve neonatal outcomes. Further studies are required for a better understanding of these associations and whether prevention or more rapid diagnosis and treatment can lower these risks.
Coalition and contradiction in managing Brahmaputra: Opportunities for more hydropower?
Authors: Xu Hongzhang , Pittock Jamie , Kamruzzaman Md , Acharya Sagar 
Published: October 2022

Abstract
Transboundary sharing of river water is not just an international problem, and it also cascades down to regional, state and local levels. Water cooperation in the Brahmaputra River basin among China, India, Bhutan and Bangladesh has long been contested. Better transboundary management of Brahmaputra requires a new direction from the current situation of fragmented cooperation, conflicts and disputes in the region and increasing threats of climate change. However, it is unclear how the four countries can cooperate and what the cornerstones for their cooperation might be. To explore possible consensus, we conducted an advocacy coalition assessment of the four countries based on the heterogeneous ecosystem services valued by each nation. While China and India are focused on politics, Bangladesh and Bhutan are primarily concerned about the basin in physical terms. Although each nation values the Brahmaputra in different ways, it is possible to initiate strong collaboration based on shared beliefs. We find that developing hydropower sustainably meets the needs and expectations of all nations, especially under the threats of climate change. A sustainable hydropower coalition can help to reduce carbon emissions, acquire green energy, irrigate land in dry seasons, and manage disasters and increasing runoffs from melting glaciers. We conclude our paper with insights for each nation and hydropower development as a whole that might help the nations to manage the Brahmaputra River more sustainably by overcoming their unmatched or mismatched values and interest, and achieving a win-win solution to manage the Brahmaputra River more sustainably.
The Effect of AI-based Techniques on Photovoltaic Power Generation under Shaded Environments
Authors: Ncir Noamane , Akchioui Nabil El 
Published: October 2022

Abstract
Due to the current emphasis on applying Artificial Intelligence (AI) techniques to Renewable Energy (RE) systems, particularly Photovoltaic (PV), a thorough study of Maximum Power Point Tracking (MPPT) control techniques-based AI approaches, particularly Fuzzy Logic Controller (FLC), Artificial Neural Network (ANN), and Adaptive Neural Fuzzy Inference System (ANFIS), is performed under various climatic conditions to demonstrate the best AI approach for the goal of maximizing the power generated by the PV panel. Consequently, the training performance of the Artificial Neural Network based Bayesian Regularization (ANN-BR) technique is compared in the first section of this study using a variety of ANN configurations. Applying 13 neurons in the hidden layer of the neural model provides for better convergence while reducing the fitness function's value to 3.9935E-14 within only 128 epochs, which demonstrate its efficiency and speed above alternative ANN designs. The second simulation in this study compares the benefits and limitations of the aforementioned AI algorithms in order to establish the optimum way for locating the Maximum Power Point (MPP) under Partial Shading (PS) conditions. As a result, the ANN-BR strategy shown its fastness in tracking the MPP, while the ANFIS approach demonstrated an excellent energy efficiency by outperforming the other strategies in three of four situations. The effectiveness of the proposed technique is investigated using flow simulations in the MATLAB ®program.
Gastroblastoma mimics the embryonal mesenchyme of the foregut: A case report.
Authors: Sugimoto Ryo , Uesugi Noriyuki , Yamada Noriyuki , Osakabe Mitsumasa , Baba Shigeaki , Yanagawa Naoki , Akiyama Yuji , Habano Wataru , Sasaki Akira , Oda Yoshinao , Sugai Tamotsu 
Published: October 2022

Abstract
Background

Gastroblastoma is a rare gastric tumor composed of epithelial and spindle cell components. Identification of the characteristic MALAT–GLI1 fusion gene has only been reported in 5 cases. We report the morphological characterization of gastroblastoma with the MALAT1–GLI1 fusion gene in a young Japanese woman.

Case presentation

A 29-year-old Japanese woman visited Iwate Medical University Hospital with upper abdominal pain. Computed tomography revealed a tumor in the expansive lesions involving the gastric antrum. Histologically, we observed a biphasic morphology composed of epithelial and spindle cell components. The epithelial components appeared as slit-like glandular structures and tubular or rosette-like differentiation. The spindle cell components consisted of short spindle-shaped oval cells. Immunohistochemical (IHC) analysis revealed that the spindle cell component was positive for vimentin, CD10, CD56, GLI1, HDAC2 and focally positive for PD-L1. The epithelial component was positive for CK AE1AE3, CAM5.2, CK7, and negative for CK20 and EMA. Both components were negative for KIT, CD34, DOG1, SMA, desmin, S100 protein, chromogranin A, synaptophysin, CDX2, and SS18-SSX. Finally, MALAT-GLI1 fusion gene was molecularly detected.

Conclusions

We report the following new findings with this case: (i) gastric tumors mimic the gastrointestinal mesenchyme in the embryonic period; (ii) nuclear expression of PD-L1 and HDAC2 were observed in the spindle cell component of gastroblastoma. We speculate that HDAC (Histone Deacetylase) inhibitors may offer a promising treatment option for gastroblastoma.