bluuebunny/crossref_metadata_2025_split huggingface dataset:
AbobotulinumtoxinA is effective in patients with urinary incontinence due to neurogenic detrusor overactivity regardless of spinal cord injury or multiple sclerosis etiology: Pooled analysis of two phase III randomized studies (CONTENT1 and CONTENT2)
Authors: Denys Pierre , Castaño Botero Juan Carlos , Vita Nunes Ricardo Luis , Wachs Barton , Mendes Gomes Cristiano , Krivoborodov Grigory , Tu Le Mai , Del‐Popolo Giulio , Thompson Catherine , Vilain Claire , Volteau Magali , Kennelly Michael ,   Dysport CONTENT program group
Published: November 2022

AbstractBackgroundNeurogenic detrusor overactivity incontinence (NDOI) is often inadequately managed with oral therapy.ObjectiveTo assess efficacy and safety of abobotulinumtoxinA (aboBoNT‐A; Dysport®; Ipsen Ltd.) according to etiology of NDOI.Design, Setting, and ParticipantsTwo phase III, randomized, double‐blind studies (CONTENT1 [NCT02660138] conducted in Asia, Europe and North America; CONTENT2 [NCT02660359] conducted in the Americas, Asia, Europe and Oceania) both included patients with spinal cord injury (SCI) or multiple sclerosis (MS), with inadequately managed NDOI, regularly performing clean intermittent catheterization (CIC).InterventionPatients in CONTENT1 and CONTENT2 received aboBoNT‐A injections 600 U (n = 162)/800 U (n = 161), or placebo (n = 162) into the detrusor muscle.Outcome Measurements and Statistical AnalysisPrimary endpoint: mean change from baseline in number of NDOI episodes/week at Week 6. Secondary endpoints: proportion of patients with no NDOI episodes; incontinence‐related quality of life (I‐QoL); urodynamic parameters; and time‐to‐retreatment. Safety was also assessed. Statistical analyses were conducted for pooled populations by etiology (aboBoNT‐A doses vs. placebo).Results and LimitationsOf 485 randomized patients, 341 (70%) and 144 (30%) had SCI and MS etiologies, respectively. A significant reduction was observed in mean NDOI episodes/week at Week 6 with both aboBoNT‐A doses versus placebo in the SCI (all p < 0.001) and MS (all p < 0.01) groups, as well as significant improvements in I‐QoL and urodynamic parameters. Median time‐to‐retreatment was longer in patients with MS (48–62 weeks across doses) than those with SCI (39–44 weeks). Safety data were similar between etiologies. Urinary tract infection was the most frequent adverse event; similar numbers were reported across treatment groups.ConclusionsAboBoNT‐A was well tolerated and significantly improved continence and bladder function, and QoL, in patients with SCI or MS with NDOI performing regular CIC.Patient SummaryAboBoNT‐A injections improved QoL, symptoms, and bladder function in patients with SCI or MS with bladder muscle overactivity that causes incontinence.
Nongovernmental organizations' leaders' attitude toward social innovation: The validation of a research tool
Authors: Pasikowski Sławomir , Zajda Katarzyna Karolina 
Published: November 2022

AbstractThis paper presents the results of a validation study of an inventory to measure the attitude of leaders of nongovernmental organizations (NGOs) toward social innovation related to solving local social problems. The study was conducted using a cross‐validation model and an innovative item cluster analysis method to analyze the data, assessing factor structure, the internal consistency of the test, criterion validity, and stability over time. The results indicate a one‐factor structure for the phenomenon and satisfactory psychometric properties for the inventory. The tool makes possible a study of NGO leaders' attitudes toward social innovation to facilitate the design of educational programs related to solving social problems through social innovation.
Monoacylglycerol O‐acyltransferase 1 lowers adipocyte differentiation capacity in vitro but does not affect adiposity in mice
Authors: Singer Jason M. , Shew Trevor M. , Ferguson Daniel , Renkemeyer M. Katie , Pietka Terri A. , Hall Angela M. , Finck Brian N. , Lutkewitte Andrew J. 
Published: November 2022

AbstractObjectiveMonoacylglycerol O‐acyltransferase 1 (Mogat1), a lipogenic enzyme that converts monoacylglycerol to diacylglycerol, is highly expressed in adipocytes and may regulate lipolysis by re‐esterifying fatty acids released during times when lipolytic rates are low. However, the role of Mogat1 in regulating adipocyte fat storage during differentiation and diet‐induced obesity is relatively understudied.MethodsHere, adipocyte‐specific Mogat1 knockout mice were generated and subjected to a high‐fat diet to determine the effects of Mogat1 deficiency on diet‐induced obesity. Mogat1 floxed mice were also used to develop preadipocyte cell lines wherein Mogat1 could be conditionally knocked out to study adipocyte differentiation in vitro.ResultsIn preadipocytes, it was found that Mogat1 knockout at the onset of preadipocyte differentiation prevented the accumulation of glycerolipids and reduced the differentiation capacity of preadipocytes. However, the loss of adipocyte Mogat1 did not affect weight gain or fat mass induced by a high‐fat diet in mice. Furthermore, loss of Mogat1 in adipocytes did not affect plasma lipid or glucose concentrations or insulin tolerance.ConclusionsThese data suggest Mogat1 may play a role in adipocyte differentiation in vitro but not adipose tissue expansion in response to nutrient overload in mice.
Cost‐effectiveness of a motivational interviewing obesity intervention versus usual care in pediatric primary care offices
Authors: Woolford Susan J. , Resnicow Kenneth , Davis Matthew M. , Nichols Lauren P. , Wasserman Richard C. , Harris Donna , Gebremariam Achamyeleh , Shone Laura , Fiks Alexander G. , Chang Tammy 
Published: November 2022

AbstractObjectiveThis study aimed to assess the incremental cost‐effectiveness ratio (ICER) of a 2‐year motivational interviewing (MI) intervention versus usual primary care.MethodsA national trial was implemented in the Pediatric Research in Office Settings (PROS) network of the American Academy of Pediatrics to evaluate MI versus usual care for children (2‐8 years old; baseline BMI 85th‐97th percentiles). Health care use, food costs, provider fees, and training costs were assessed, and sensitivity analyses were conducted. Primary outcome was the ICER, calculated as cost per unit change in BMI percentile for intervention versus usual care.ResultsAt 2 years, 72% of enrolled parent/child dyads were retained; 312 children were included in the analysis. Mean BMI percentile point change was −4.9 and −1.8 for the intervention and control, respectively, yielding an incremental reduction of 3.1 BMI percentile points (95% CI: 1.2‐5.0). The intervention cost $1051 per dyad ($658 for training DVD development). Incorporating health care and non‐health care costs, the intervention ICER was $363 (range from sensitivity analyses: cost saving, $3159) per BMI percentile point decrease per participant over 2 years.ConclusionsTraining pediatricians, nurse practitioners, and registered dietitians to deliver MI‐based interventions for childhood obesity in primary care is clinically effective and acceptably cost‐effective. Future work should explore this approach in broader dissemination.
Proteomics, dietary intake, and changes in cardiometabolic health within a behavioral weight‐loss intervention: A pilot study
Authors: Hill Emily B. , Siebert Janet C. , Yazza Deaunabah N. , Ostendorf Danielle M. , Bing Kristen , Wayland Liza , Scorsone Jared J. , Bessesen Daniel H. , MacLean Paul S. , Melanson Edward L. , Catenacci Victoria A. , Borengasser Sarah J. 
Published: November 2022

AbstractObjectiveIdentifying associations among circulating proteins, dietary intakes, and clinically relevant indicators of cardiometabolic health during weight loss may elucidate biologically relevant pathways affected by diet, allowing for an incorporation of precision nutrition approaches when designing future interventions. This study hypothesized that plasma proteins would be associated with diet and cardiometabolic health indicators within a behavioral weight‐loss intervention.MethodsThis secondary data analysis included participants (n = 20, mean [SD], age: 40.1 [9.5] years, BMI: 34.2 [4.0] kg/m2) who completed a 1‐year behavioral weight‐loss intervention. Cardiovascular disease‐related plasma proteins, diet, and cardiometabolic health indicators were evaluated at baseline and 3 months. Associations were determined via linear regression and integrated networks created using Visualization Of LineAr Regression Elements (VOLARE).ResultsA total of 16 plasma proteins were associated with ≥1 diet or health indicator at baseline (p < 0.001); changes in 42 proteins were associated with changes in diet or health indicators from baseline to 3 months (p < 0.005). Baseline tumor necrosis factor receptor superfamily member 10C (TNFRSF10C) was associated with intakes of dark green vegetables (r = −0.712), and fatty acid‐binding protein 4 (FABP4) was associated with intakes of unsweetened coffee (r = −0.689). Changes in refined‐grain intakes were associated with changes in scavenger receptor cysteine‐rich type 1 protein M130 (CD163; r = 0.725), interleukin‐1 receptor type 1 (IL1R‐T1; r = 0.624), insulin (r = 0.656), and triglycerides (r = 0.648).ConclusionsCirculating cardiovascular disease‐related proteins were associated with diet and cardiometabolic health indicators prior to and in response to weight loss.image
Muscle fat contents rather than muscle mass determines nonalcoholic steatohepatitis and liver fibrosis in patients with severe obesity
Authors: Han Eugene , Kim Mi Kyung , Lee Hye Won , Ryu Seungwan , Kim Hye Soon , Jang Byoung Kuk , Suh Youngsung 
Published: November 2022

AbstractObjectiveThis study aimed to investigate the association of muscle fat contents, nonalcoholic steatohepatitis (NASH), and liver fibrosis in patients with severe obesity.MethodsPatients with severe obesity who underwent bariatric surgery were evaluated for NASH and liver fibrosis. Skeletal muscle was assessed by dual energy x‐ray absorptiometry, and muscle fat contents (skeletal muscle fat index [SMFI]) were evaluated by computed tomography‐based psoas muscle mass and density.ResultsA total of 104 patients with severe obesity were enrolled (57 with nonalcoholic fatty liver disease activity score <5 and 47 with NASH with nonalcoholic fatty liver disease activity score ≥5). SMFI was higher in patients with NASH than those without NASH (mean [SD], 39.0 [14.5] vs. 46.5 [14.2] for without NASH vs. with NASH; p = 0.009). SMFI was also correlated with hepatic steatosis grade, ballooning severity, and fibrosis stage. Multiple logistic regression analysis showed that SMFI was associated with higher risk of NASH and liver fibrosis (odds ratio = 2.37, 95% CI: 1.13‐4.98, p = 0.022 for NASH; odds ratio = 2.93, 95% CI: 1.32‐6.48, p = 0.008 for significant liver fibrosis).ConclusionsMuscle fat infiltration rather than muscle mass reflects the severities of hepatic steatosis and fibrosis in patients with severe obesity.
An investigation of crystallization kinetics of polyoxymethylene in processing conditions
Authors: Volpe Valentina , Speranza Vito , Schrank Theresia , Berer Michael , Pantani Roberto 
Published: November 2022

AbstractIn this work, a very wide set of quiescent isothermal and non‐isothermal calorimetric experiments are carried out in order to analyze POM crystallization kinetics also under cooling rates comparable to those experienced by the polymer during processing. To investigate the effect of flow on the POM crystallization behavior, also some Linkam shearing tests are conducted. An enhancement of the POM crystallization process is observed under flow. A Kolmogoroff–Avrami–Evans (KAE) model for quiescent crystallization is proposed. It is based on nucleation (considering both a homogeneous and a heterogeneous process) and growth mechanisms. Model parameters of nucleation and growth are determined, and the overall model is able to describe the POM crystallization process in the whole cooling rate range adopted for the experiments. This allows to obtain a reliable description of the POM crystallization evolution during processing and provides important knowledge for managing the POM injection molding process and the final physical properties of POM products.
Worry and fear during the COVID‐19 epidemic normalization: Analyzing prevalence and risk factors among 182,991 high school students in China
Authors: Xu Qingqing , Fan Keliang , Wei Dandan , Liu Pengling , Wang Juan , Wang Xian , Lou Xiaomin , Lin Hualiang , Wang Chongjian , Wu Cuiping , Mao Zhenxing 
Published: November 2022

AbstractIt is worth paying attention to the level of worry and fear of students during the normalization of the epidemic. We conducted the cross‐sectional study that included 182,991 high school students using an online survey to assess worry and fear levels and its influencing factors in three cities in Henan Province, China, from May 21 to May 27, 2021. Worry and fear levels were measured using a five‐item Likert‐type scale. Multinomial logistic regression was used to analyze the risk factors. Approximately 65.42% of students reported being high worry about the coronavirus disease 2019 (COVID‐19) epidemic, and about 41.44% of students reported being high fear about the COVID‐19 epidemic. In addition, compared with female, male had lower odds of suffering from a high worry, and compared with senior high school students, junior high school students were more likely to suffer from a high worry. Students lived in rural had highest odds increased likelihood of high worry. Similar results in fear levels. During the normalization period of the COVID‐19 epidemic, many students have high levels of worry and fear. This study has implications for potential influencers of worry and fear levels in follow‐up work.
Registration of seven powdery mildew‐resistant wild hop germplasm lines
Authors: Havill Joshua S. , Wiseman Michele S. , Henning John A. , Gent David H. , Muehlbauer Gary J. 
Published: November 2022

AbstractCultivation of common hop (Humulus lupulus L.) has increased dramatically during the past decade, with the primary growth occurring in the Pacific Northwest of the United States. A major limitation to hop production is hop powdery mildew [caused by Podosphaera macularis (Wallr.) Braun & Takam]. To date, a comprehensive evaluation of wild hop germplasm resources for resistance to hop powdery mildew has yet to be conducted. Herein, we report the first extensive powdery mildew resistance screening of 244 wild H. lupulus populations (6,732 individuals) collected from North America and Eurasia. We used an elimination screening approach by sequentially inoculating four P. macularis isolates containing virulence on all previously described R genes. We detected the presence of powdery mildew resistance to isolates representing extant pathogenic diversity in seven germplasms (UMN‐PMR‐002 Male [Reg. no. GP‐38, PI 699936], UMN‐PMR‐005 [Reg. no. GP‐39, PI 699937], UMN‐PMR‐006 Female [GP‐40, PI 699938], UMN‐PMR‐007 Male [Reg. no. GP‐41, PI 699939], UMN‐PMR‐008 [Reg. no. GP‐042, PI 699940], UMN‐PMR‐010 Male [Reg. no. GP‐43, OU 699941], UMN‐PMR‐013 Female [Reg. no. GP‐44, PI 699942]). Based upon genotypic profiling, the seven germplasms were identified in H. lupulus var. lupulus originating from Eurasia. These accessions could be used to introgress broad‐spectrum powdery mildew resistance in hop breeding programs worldwide.
Integrating machine learning, remote sensing and citizen science to create an early warning system for biodiversity
Authors: Antonelli Alexandre , Dhanjal‐Adams Kiran L. , Silvestro Daniele 
Published: November 2022

Societal Impact StatementThe development and implementation of conservation actions that address urgent threats to biodiversity across the globe require large amounts of historic and current data. Machine learning approaches offer the tools to process, analyse and interpret large data sets, giving insights into trends and guiding evidence‐based allocation of limited resources to maximise positive biodiversity outcomes. Here we describe how data acquired from remote sensing, citizen science and other monitoring approaches could feed in near‐real time into an early warning system for biodiversity that integrates automated red‐listing of species with the identification of priority areas for conservation.SummaryApplication of machine learning approaches is aiding biodiversity conservation and research at a time of rapid global change. Two emerging topics and their data requirements are presented. First, to identify areas of priority protection for preventing biodiversity loss, reinforcement learning is used by training models that take into account human disturbance and climate change under recurrent monitoring schemes. Second, neural networks are used to approximate classification of species into Red List categories of the International Union for Conservation of Nature, offering the possibility of real‐time re‐classification after events such as widespread fires and deforestation. We discuss how the identification of areas and species most at risk could be integrated into an ‘early warning system’ based on climatic monitoring, remotely sensed land‐use changes and near‐real time biological and threat data from citizen science initiatives. Such system would help guide actions to prevent biodiversity loss at the speed required for effective conservation.
Prognostic potential and mechanism of SORT1 and its co‐expressed genes in hepatocellular carcinoma based on integrative analysis of multiple database
Authors: Lin Minjie , Zhu Mengying , Ge Tingqiu , Lu Naiying , Fu Xiling , Chang Jiabao 
Published: November 2022

AbstractAbnormal SORT1 expression has been reported in various cancers. However, the expression and function of SORT1 in hepatocellular carcinoma (HCC) remain to be explored. This study aims to explore the expression and function of SORT1 and to identify its co‐expressed genes in HCC. Various gene expression databases were applied in our analysis. We found SORT1 was up‐regulated in HCC tumor tissues and high SORT1 expression level was associated with worse overall survival (OS). Co‐expressed genes with SORT1 and its potential regulators were explored using LinkedOmics. Functional network analysis of co‐expressed genes by Metascape revealed that they participated in aberrant lipid metabolism, AMPK signaling pathway, and PPAR signaling pathway which were all strongly linked to the pathogenesis of HCC. In addition, co‐expression genes were analyzed by Cytoscape to identify their hub genes, which included CYB5A, CYP2C9, CYP3A5, CYP4A11, and POR. The mRNA expression level of CYP2C9, CYP3A5, and CYP4A11 were down‐regulated in HCC tumor tissues via GEPIA. High hub genes expression level was associated with better OS and progression free survival (PFS) in HCC. The correlations between SORT1 and hub genes with cancer immune infiltrates were investigated by TIMER. Notably, SORT1 and hub genes expression was positively correlated with infiltrating levels of different immune cells. Our findings suggested that high SORT1 expression level predicted dismal prognosis in HCC and its possible mechanism was immune‐related.
Inline small‐angle X‐ray scattering‐coupled chromatography under extreme hydrostatic pressure
Authors: Miller Robert C. , Cummings Cody , Huang Qingqiu , Ando Nozomi , Gillilan Richard E. 
Published: November 2022

AbstractAs continuing discoveries highlight the surprising abundance and resilience of deep ocean and subsurface microbial life, the effects of extreme hydrostatic pressure on biological structure and function have attracted renewed interest. Biological small‐angle X‐ray scattering (BioSAXS) is a widely used method of obtaining structural information from biomolecules in solution under a wide range of solution conditions. Due to its ability to reduce radiation damage, remove aggregates, and separate monodisperse components from complex mixtures, size‐exclusion chromatography‐coupled SAXS (SEC‐SAXS) is now the dominant form of BioSAXS at many synchrotron beamlines. While BioSAXS can currently be performed with some difficulty under pressure with non‐flowing samples, it has not been clear how, or even if, continuously flowing SEC‐SAXS, with its fragile media‐packed columns, might work in an extreme high‐pressure environment. Here we show, for the first time, that reproducible chromatographic separations coupled directly to high‐pressure BioSAXS can be achieved at pressures up to at least 100 MPa and that pressure‐induced changes in folding and oligomeric state and other properties can be observed. The apparatus described here functions at a range of temperatures (0°C–50°C), expanding opportunities for understanding biomolecular rules of life in deep ocean and subsurface environments.
Israeli‐Jewish immigrants in Germany: An assessment of the destination‐language acquisition model and the role of Holocaust memory
Authors: Rebhun Uzi 
Published: November 2022

AbstractSince its reunification in 1990, Germany has been the destination of a large number of immigrants from Israel. They chose to settle in a country that is associated with the greatest tragedy in Jewish history, the Holocaust. Furthermore, they were raised in a country in which Holocaust memory and commemoration are major component of group identity. Within this context, the present study uses data from a survey carried out in 2014/2015 among Israeli‐Jewish immigrants in Germany (N = 510) to assess their linguistic adjustment in the new country. Incorporating factors of Holocaust memory (noneconomic incentives) into the model of destination‐language acquisition (MDLA), I ran similar equations for the three uses of language: speaking, reading and writing. Results from the multivariate analysis suggest that Holocaust memory does not inhibit the immigrants' proficiency in the German language. Accordingly, I adapt the indifference hypothesis, centring on maximizing gains and pleasure, and refute the two competing hypotheses, disruption and heightening. Variables of the MDLA—exposure, efficiency and economic incentives, and, especially, duration in the host country and young age at immigration—are significantly associated with proficiency in German; they were able to explain much of the variation in each of the uses of language. In the Discussion, I venture a proposal as to how fluency in German may help to attenuate intergroup tensions.