bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developmental changes in action-outcome regularity perceptual sensitivity and its relationship to hand motor function in 5–16-year-old children
Authors: Nobusako Satoshi , Wen Wen , Nagakura Yusuke , Tatsumi Mitsuyo , Kataoka Shin , Tsujimoto Taeko , Sakai Ayami , Yokomoto Teruyuki , Takata Emiko , Furukawa Emi , Asano Daiki , Osumi Michihiro , Nakai Akio , Morioka Shu 
Published: October 2022

AbstractAlong with the comparator model, the perception of action-outcome regularity is involved in the generation of sense of agency. In addition, the perception of action-outcome regularity is related to motor performance. However, no studies have examined the developmental changes in the perception of action-outcome regularity. The current study measured perceptual sensitivity to action-outcome regularity and manual dexterity in 200 children aged between 5 and 16 years. The results showed that perceptual sensitivity to action-outcome regularity was significantly lower in 5–6-year-old children than in 9–16-year-old children, and that it was significantly lower in children with low manual dexterity than in children with medium to high manual dexterity. Correlation analyses revealed significant correlations of age and perceptual sensitivity to action-outcome regularity, but no significant correlation of manual dexterity and perceptual sensitivity to action-outcome regularity, either overall or in any age band. The present study suggests that perceptual sensitivity to action-outcome regularity is immature at 5–6 years of age and that it may be impaired in 5–16-year-old children with poor manual dexterity.
Influencing factors of coking coal dust explosion pressure and flame and effect of inert dust on its explosion suppression
Authors: Liu Tianqi , Zhao Xuan , Tian Weiye , Jia Ruiheng , Wang Ning , Cai Zhixin 
Published: October 2022

AbstractCoking coal is a precious resource in the world and an important raw material for the production of steel, but it is easy to cause explosion accidents in the process of coking coal mining, which is very detrimental to safe production. In order to reveal the influencing factors of coking coal dust explosion intensity and the suppression effect of inert dust on coking coal dust explosion, an experimental study was carried out in this paper. The results show that the particle size and the mass concentration of coal dust have a great influence on the explosion pressure and flame. By analyzing the suppression effects of NaCl, KCl, and NH4H2PO4 on coking coal dust explosion, it is got that NH4H2PO4 has the best explosion suppression effect. When the mass percentage of NH4H2PO4 mixed into coking coal dust increases to 60%, the maximum explosion pressure decreases by 0.47 MPa, and the maximum flame length decreases by 0.50 m. As the particle size of NH4H2PO4 decreases, the explosion intensity continue to decrease. When the particle size of NH4H2PO4 is 0 ~ 25 μm, and the mass percentage of NH4H2PO4 mixed into coking coal dust is 50%, the explosion doesn’t occur anymore.
Sarcopenia and mortality risk in community-dwelling Brazilian older adults
Authors: Pereira Cristina Camargo , Pagotto Valéria , de Oliveira Cesar , Silveira Erika Aparecida 
Published: October 2022

AbstractWe estimated the impact of sarcopenia parameters on mortality risk and assessed its prevalence and associated factors in the older adults according to the European Working Group on Sarcopenia in Older People’s 2010 (EWGSOP1) and 2018 (EWGSOP2) criteria. This was a 10-year follow-up cohort study. Low muscle mass (MM) was defined as low skeletal muscle mass index (SMI) using dual-energy X-ray absorptiometry (DXA), and low calf circumference (CC). Cox regression and the Kaplan–Meier method were performed. The prevalence of sarcopenia and associated factors were influenced by the MM measurement method and diagnostic criteria used [6.8% (SMI and EWGSOP2), 12.8% (CC and EWGSOP2; and SMI and EWGSOP1) and 17.4% (CC and EWGSOP1)]. While a low BMI was associated with sarcopenia regardless of the sarcopenia definitions, diabetes, and high TGs were associated with sarcopenia only when using the EWGSOP1 criteria. Low SMI increased mortality risk (EWGSOP1: HR = 2.01, 95% CI 1.03–3.92; EWGSOP2: HR = 2.07, 95% CI 1.05–4.06). The prevalence of sarcopenia was higher according to EWGSOP1 than EWGSOP2. A low BMI, diabetes, and high TGs were associated with sarcopenia. A low SMI doubled the risk of mortality in community-dwelling older adults.
Sociodemographic characteristics and health-related quality of life of individuals undergoing antidepressant therapy
Authors: Alfaifi Abdullah A. , Althemery Abdullah U. 
Published: October 2022

AbstractAn important factor for averting depression and creating awareness about clinical treatment is patient preference. Therefore, investigating health-related quality of life associated with different antidepressants is necessary. A retrospective cohort study was performed using the 2018 Medical Expenditure Panel Survey. The MEPS is a nationally representative database of the civilian and noninstitutionalized population spanning different ages, both sexes, and a wide range of sociodemographic and economic backgrounds. Differences in clinical and sociodemographic characteristics among patients using different antidepressant classes were explored. The differences in Veterans RAND 12-Item Health Survey (VR-12) results among groups were examined. The VR-12 metric was used since it measures a patient’s overall perspective of their health. Approximately 34.6 million of the patients reported using at least one antidepressant during 2018. Most patients receiving tricyclic therapy reported substantially better mental HRQoL than patients receiving selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), or combination therapy. Patients receiving atypical antidepressants reported substantially better mental HRQoL than those receiving other types of antidepressants. Most patients reported a substantial decline in HRQoL after SNRIs or combination therapy. This study found that HRQoL varied across antidepressant users. Thus, health care providers could benefit from taking into consideration quality of life when prescribing antidepressant agents. Moreover, further research is needed to explore other factors that could contribute to the quality of care for patients with depression.
Recapitulation of the embryonic transcriptional program in holometabolous insect pupae
Authors: Ozerova Alexandra M. , Gelfand Mikhail S. 
Published: October 2022

AbstractHolometabolous insects are predominantly motionless during metamorphosis, when no active feeding is observed and the body is enclosed in a hardened cuticle. These physiological properties as well as undergoing processes resemble embryogenesis, since at the pupal stage organs and systems of the imago are formed. Therefore, recapitulation of the embryonic expression program during metamorphosis could be hypothesized. To assess this hypothesis at the transcriptome level, we have performed a comprehensive analysis of the developmental datasets available in the public domain. Indeed, for most datasets, the pupal gene expression resembles the embryonic rather than the larval pattern, interrupting gradual changes in the transcriptome. Moreover, changes in the transcriptome profile during the pupa-to-imago transition are positively correlated with those at the embryo-to-larvae transition, suggesting that similar expression programs are activated. Gene sets that change their expression level during the larval stage and revert it to the embryonic-like state during the metamorphosis are enriched with genes associated with metabolism and development.
A comprehensive evaluation of polygenic score and genotype imputation performances of human SNP arrays in diverse populations
Authors: Nguyen Dat Thanh , Tran Trang T. H. , Tran Mai Hoang , Tran Khai , Pham Duy , Duong Nguyen Thuy , Nguyen Quan , Vo Nam S. 
Published: October 2022

AbstractRegardless of the overwhelming use of next-generation sequencing technologies, microarray-based genotyping combined with the imputation of untyped variants remains a cost-effective means to interrogate genetic variations across the human genome. This technology is widely used in genome-wide association studies (GWAS) at bio-bank scales, and more recently, in polygenic score (PGS) analysis to predict and stratify disease risk. Over the last decade, human genotyping arrays have undergone a tremendous growth in both number and content making a comprehensive evaluation of their performances became more important. Here, we performed a comprehensive performance assessment for 23 available human genotyping arrays in 6 ancestry groups using diverse public and in-house datasets. The analyses focus on performance estimation of derived imputation (in terms of accuracy and coverage) and PGS (in terms of concordance to PGS estimated from whole-genome sequencing data) in three different traits and diseases. We found that the arrays with a higher number of SNPs are not necessarily the ones with higher imputation performance, but the arrays that are well-optimized for the targeted population could provide very good imputation performance. In addition, PGS estimated by imputed SNP array data is highly correlated to PGS estimated by whole-genome sequencing data in most cases. When optimal arrays are used, the correlations of PGS between two types of data are higher than 0.97, but interestingly, arrays with high density can result in lower PGS performance. Our results suggest the importance of properly selecting a suitable genotyping array for PGS applications. Finally, we developed a web tool that provides interactive analyses of tag SNP contents and imputation performance based on population and genomic regions of interest. This study would act as a practical guide for researchers to design their genotyping arrays-based studies. The tool is available at:https://genome.vinbigdata.org/tools/saa/.
Sugar-terminated carbon-nanodots stimulate osmolyte accumulation and ROS detoxification for the alleviation of salinity stress in Vigna radiata
Authors: Sarkar Mahima Misti , Pradhan Nibedita , Subba Rewaj , Saha Puja , Roy Swarnendu 
Published: October 2022

AbstractIn recent times, nanotechnology has emerged as an efficient tool to manage the adverse effect of environmental stresses on plants. In this connection, carbon-nanodots (CNDs) have been reported to ameliorate the negative impacts of salinity stress. Further, surface modification of CNDs is believed to augment their stress-alleviating potential, however, very little has been known about the potential of surface-functionalized CNDs. In this purview, two sugar (trehalose and glucose) terminated CNDs (CNPT and CNPG) have been synthesized and assessed for their stress-alleviating effects onVigna radiata(a salt-sensitive legume) seedlings subjected to different concentrations of NaCl (0, 50, and 100 mM). The synthesized CNDs (CNPT and CNPG) exhibited a hydrodynamic size of 20–40 nm and zeta potential of up to − 22 mV with a 5–10 nm core. These water-soluble nanomaterials exhibited characteristic fluorescence emission properties viz.orange and greenish-yellow for CNPT and CNPG respectively. The successful functionalization of the sugar molecules on the CND cores was further confirmed using FTIR, XRD, and AFM. The results indicated that the application of both the CNDs improved seed germination, growth, pigment content, ionic and osmotic balance, and most importantly, the antioxidant defense which decreased ROS accumulation. At the same time, CNPT and CNPG exhibited no toxicity in theAllium ceparoot tip bioassay. Therefore, it can be concluded that sugar-terminated CNDs improved the plant responses to salinity stress by facilitating sugar uptake to the aerial part of the seedlings.
Attention neuroenhancement through tDCS or neurofeedback: a randomized, single-blind, controlled trial
Authors: Rêgo Gabriel Gaudencio , Gonçalves Óscar F. , Boggio Paulo Sérgio 
Published: October 2022

AbstractNeurofeedback and transcranial Direct Current Stimulation (tDCS) are promising techniques for neuroenhancement of attentional performance. As far as we know no study compared both techniques on attentional performance in healthy participants. We compared tDCS and neurofeedback in a randomized, single-blind, controlled experiment assessing both behavioral (accuracy and time reaction) and electrophysiological (N1, P1, and P3 components) data of participants responding to the Attention Network Task (ANT). Eighty volunteers volunteered for this study. We adopted standard protocols for both techniques, i.e., a Sensorimotor Rhythm (SMR) protocol for neurofeedback and the right DLPFC anodal stimulation for tDCS, applied over nine sessions (two weeks). We did not find significant differences between treatment groups on ANT, neither at the behavioral nor at the electrophysiological levels. However, we found that participants from both neuromodulation groups, irrespective of if active or sham, reported attentional improvements in response to the treatment on a subjective scale. Our study adds another null result to the neuromodulation literature, showing that neurofeedback and tDCS effects are more complex than previously suggested and associated with placebo effect. More studies in neuroenhancement literature are necessary to fully comprehend neuromodulation mechanisms.
A critical path to producing high quality, reproducible data from quantitative western blot experiments
Authors: Taylor Sean C. , Rosselli-Murai Luciana K. , Crobeddu Bélinda , Plante Isabelle 
Published: October 2022

AbstractWestern blotting experiments were initially performed to detect a target protein in a complex biological sample and more recently, to measure relative protein abundance. Chemiluminescence coupled with film-based detection was traditionally the gold standard for western blotting but accurate and reproducible quantification has been a major challenge from this methodology. The development of sensitive, camera-based detection technologies coupled with an updated technical approach permits the production of reproducible, quantitative data. Fluorescence reagent and detection solutions are the latest innovation in western blotting but there remains questions and debate concerning their relative sensitivity and dynamic range versus chemiluminescence. A methodology to optimize and produce excellent, quantitative western blot results with rigorous data analysis from membranes probed with both fluorescent and chemiluminescent antibodies is described. The data reveal when and how to apply these detection methods to achieve reproducible data with a stepwise approach to data processing for quantitative analysis.
Multiomics analysis reveals that hepatocyte nuclear factor 1β regulates axon guidance genes in the developing mouse kidney
Authors: Shao Annie , Gearhart Micah D. , Chan Siu Chiu , Miao Zhen , Susztak Katalin , Igarashi Peter 
Published: October 2022

AbstractThe transcription factor hepatocyte nuclear factor 1β (HNF-1β) is essential for normal development of the kidney and other epithelial organs. In the developing mouse kidney, HNF-1β is required for the differentiation and patterning of immature nephrons and branching morphogenesis of the ureteric bud (UB). Here, we used ChIP-sequencing (ChIP-seq) and RNA sequencing (RNA-seq) to identify genes that are regulated by HNF-1β in embryonic mouse kidneys. ChIP-seq revealed that HNF-1β binds to 8284 sites in chromatin from E14.5 mouse kidneys. Comparison with previous ATAC-seq and histone modification studies showed that HNF-1β binding peaks colocalized with open chromatin and epigenetic marks of transcriptional activation (H3K27 acetylation, H3K4 trimethylation, H3K4 monomethylation), indicating that the binding sites were functional. To investigate the relationship between HNF-1β binding and HNF-1β-dependent gene regulation, RNA-seq was performed on UB cells purified from wild-type and HNF-1β mutant embryonic kidneys. A total of 1632 genes showed reduced expression in HNF-1β-deficient UB cells, and 485 genes contained nearby HNF-1β binding sites indicating that they were directly activated by HNF-1β. Conversely, HNF-1β directly repressed the expression of 526 genes in the UB. Comparison with snATAC-seq analysis of UB-derived cells showed that both HNF-1β-dependent activation and repression correlated with chromatin accessibility. Pathway analysis revealed that HNF-1β binds near 68 axon guidance genes in the developing kidney. RNA-seq analysis showed thatNrp1,Sema3c,Sema3d,Sema6a, andSlit2were activated by HNF-1β, whereasEfna1,Epha3,Epha4,Epha7,Ntn4,Plxna2,Sema3a,Sema4b,Slit3,Srgap1,Unc5candUnc5dwere repressed by HNF-1β. RNAscope in situ hybridization showed thatNrp1,Sema3c,Sema3d,Sema6a, andSlit2were expressed in wild-type UB and were dysregulated in HNF-1β mutant UB. These studies show that HNF-1β directly regulates the expression of multiple axon guidance genes in the developing mouse kidney. Dysregulation of axon guidance genes may underlie kidney defects in HNF-1β mutant mice.
Spontaneous instrumental avoidance learning in social contexts
Authors: Mennella Rocco , Bavard Sophie , Mentec Inès , Grèzes Julie 
Published: October 2022

AbstractAdaptation to our social environment requires learning how to avoid potentially harmful situations, such as encounters with aggressive individuals. Threatening facial expressions can evoke automatic stimulus-driven reactions, but whether their aversive motivational value suffices to drive instrumental active avoidance remains unclear. When asked to freely choose between different action alternatives, participants spontaneously—without instruction or monetary reward—developed a preference for choices that maximized the probability of avoiding angry individuals (sitting away from them in a waiting room). Most participants showed clear behavioral signs of instrumental learning, even in the absence of an explicit avoidance strategy. Inter-individual variability in learning depended on participants’ subjective evaluations and sensitivity to threat approach feedback. Counterfactual learning best accounted for avoidance behaviors, especially in participants who developed an explicit avoidance strategy. Our results demonstrate that implicit defensive behaviors in social contexts are likely the product of several learning processes, including instrumental learning.
Fully controllable multichannel waveguides induced by counterpropagating Bessel beams
Authors: Chai Yue , Marsal Nicolas , Wolfersberger Delphine 
Published: October 2022

AbstractWe theoretically analyze the waveguiding structures photo-induced by two incoherent counter-propagating Bessel beams (BBs) in a biased photorefractive crystal. We demonstrate that the cross-coupling of two BBs enables adressable channels and tunability of the forming guiding structures. The truncation parameter of the BBs, their Bessel orders and the misalignment between the two beams are all key parameters for tailoring the characteristics of the photo-induced waveguides such as the number of outputs, the output intensity levels and the distance between each output channel. Accordingly, we optimized the different parameters for designing not only a fully tunable Y-coupler but also optical splitters with up to five outputs and even more complex star couplers for all-optical interconnect applications. Finally, we report on the stability behavior of the photo-induced platform. The stability threshold depends on the nonlinearity parameter beyond which the beams display time-periodic, quasi-periodic and turbulent dynamics where spatially localized instabilities can be observed. All these results suggest more opportunities for fully controllable complex waveguiding structures and new all-optical solutions for active components in optical telecommunication and innovative ways of performing optical computing based on spatiotemporal chaos.
Diversity of myxozoans parasitizing the catfish Rhamdia quelen (Siluriformes: Heptapteridae), in southeastern Brazil, based on morphological and molecular evidence
Authors: Mirandola Dias Vieira Diego Henrique , Bravin Narciso Rodrigo , da Silva Reinaldo José 
Published: October 2022

AbstractRhamdia quelen is a commercially important fish in South America. During the survey of myxozoan infections in fishes from Pardo River, Paranapanema River basin, São Paulo State, Brazil, we describe three new species of Henneguya found parasitizing gills of R. quelen: Henneguya bagre n. sp., Henneguya breviscauda n. sp and Henneguya novaerae n. sp. The descriptions were based on myxospores morphology and small subunit ribosomal DNA partial sequences. Phylogenetic analysis showed a clade formed by species that parasitize Siluriformes, with Henneguya jundiai as a sister species of Henneguya bagre n. sp., Henneguya breviscauda n. sp and Henneguya novaerae n. sp. Our study indicates that the parasites infecting R. quelen belong to a lineage of myxozoans infecting Heptapteridae fishes. Using molecular and morphological characterization, the species were identified as new species for the genus Henneguya. Based on our analysis we recommend monitoring the presence of these parasites in farmed fishes, to analyze possible pathologies caused by them.
Hyperspectral imaging for chemicals identification: a human-inspired machine learning approach
Authors: Kendler Shai , Mano Ziv , Aharoni Ran , Raich Raviv , Fishbain Barak 
Published: October 2022

AbstractData analysis has increasingly relied on machine learning in recent years. Since machines implement mathematical algorithms without knowing the physical nature of the problem, they may be accurate but lack the flexibility to move across different domains. This manuscript presents a machine-educating approach where a machine is equipped with a physical model, universal building blocks, and an unlabeled dataset from which it derives its decision criteria. Here, the concept of machine education is deployed to identify thin layers of organic materials using hyperspectral imaging (HSI). The measured spectra formed a nonlinear mixture of the unknown background materials and the target material spectra. The machine was educated to resolve this nonlinear mixing and identify the spectral signature of the target materials. The inputs for educating and testing the machine were a nonlinear mixing model, the spectra of the pure target materials (which are problem invariant), and the unlabeled HSI data. The educated machine is accurate, and its generalization capabilities outperform classical machines. When using the educated machine, the number of falsely identified samples is ~ 100 times lower than the classical machine. The probability for detection with the educated machine is 96% compared to 90% with the classical machine.
Do open data impact citizens’ behavior? Assessing face mask panic buying behaviors during the Covid-19 pandemic
Authors: Shibuya Yuya , Lai Chun-Ming , Hamm Andrea , Takagi Soichiro , Sekimoto Yoshihide 
Published: October 2022

AbstractData are essential for digital solutions and supporting citizens’ everyday behavior. Open data initiatives have expanded worldwide in the last decades, yet investigating the actual usage of open data and evaluating their impacts are insufficient. Thus, in this paper, we examine an exemplary use case of open data during the early stage of the Covid-19 pandemic and assess its impacts on citizens. Based on quasi-experimental methods, the study found that publishing local stores’ real-time face mask stock levels as open data may have influenced people’s purchase behaviors. Results indicate a reduced panic buying behavior as a consequence of the openly accessible information in the form of an online mask map. Furthermore, the results also suggested that such open-data-based countermeasures did not equally impact every citizen and rather varied among socioeconomic conditions, in particular the education level.