bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adult T-cells impair neonatal cardiac regeneration
Authors: Dolejsi Theresa , Delgobo Murilo , Schuetz Thomas , Tortola Luigi , Heinze Katrin G , Hofmann Ulrich , Frantz Stefan , Bauer Axel , Ruschitzka Frank , Penninger Josef M , Campos Ramos Gustavo , Haubner Bernhard J 
Published: March 2022

AbstractAimsNewborn mice and humans display transient cardiac regenerative potential that rapidly declines postnatally. Patients who survive a myocardial infarction (MI) often develop chronic heart failure due to the heart’s poor regeneration capacity. We hypothesized that the cardiac ‘regenerative-to-scarring’ transition might be driven by the perinatal shifts observed in the circulating T-cell compartment.Methods and resultsPost-MI immune responses were characterized in 1- (P1) vs. 7-day-old (P7) mice subjected to left anterior descending artery ligation. Myocardial infarction induced robust early inflammatory responses (36 h post-MI) in both age groups, but neonatal hearts exhibited rapid resolution of inflammation and full functional recovery. The perinatal loss of myocardial regenerative capacity was paralleled by a baseline increase in αβ-T cell (CD4+ and CD8+) numbers. Strikingly, P1-infarcted mice reconstituted with adult T-cells shifted to an adult-like healing phenotype, marked by irreversible cardiac functional impairment and increased fibrosis. Infarcted neonatal mice harbouring adult T-cells also had more monocyte-derived macrophage recruitment, as typically seen in adults. At the transcriptome level, infarcted P1 hearts that received isolated adult T-cells showed enriched gene sets linked to fibrosis, inflammation, and interferon-gamma (IFN-γ) signalling. In contrast, newborn mice that received isolated Ifng –/– adult T-cells prior to MI displayed a regenerative phenotype that resembled that of its age-matched untreated controls.ConclusionPhysiological T-cell development or adoptive transfer of adult IFN-γ-producing T-cells into neonates contributed to impaired cardiac regeneration and promoted irreversible structural and functional cardiac damage. These findings reveal a trade-off between myocardial regenerative potential and the development of T-cell competence.
Kidney transplantation and withdrawal rates among wait-listed first-generation immigrants in Italy
Authors: Grossi Alessandra Agnese , Puoti Francesca , Fiaschetti Pamela , Di Ciaccio Paola , Maggiore Umberto , Cardillo Massimo 
Published: March 2022

Abstract

Background
Multiple barriers diminish access to kidney transplantation (KT) in immigrant compared to non-immigrant populations. It is unknown whether immigration status reduces the likelihood of KT after wait-listing despite universal healthcare coverage with uniform access to transplantation.

Methods
We retrospectively collected data of all adult waiting list (WL) registrants in Italy (2010–20) followed for 5 years until death, KT in a foreign center, deceased-donor kidney transplant (DDKT), living-donor kidney transplant (LDKT) or permanent withdrawal from the WL. We calculated adjusted relative probability of DDKT, LDKT and permanent WL withdrawal in different immigrant categories using competing-risks multiple regression models.

Results
Patients were European Union (EU)-born (n = 21 624), Eastern European-born (n = 606) and non-European-born (n = 1944). After controlling for age, sex, blood type, dialysis vintage, case-mix and sensitization status, non-European-born patients had lower LDKT rates compared to other immigrant categories: LDKT adjusted relative probability of non-European-born vs. Eastern European-born 0.51 (95% CI: 0.33–0.79; P = 0.002); of non-European-born vs. EU-Born: 0.65 (95% CI: 0.47–0.82; P = 0.001). Immigration status did not affect the rate of DDKT or permanent WL withdrawal.

Conclusions
Among EU WL registrants, non-European immigration background is associated with reduced likelihood of LDKT but similar likelihood of DDKT and permanent WL withdrawal. Wherever not available, new national policies should enable coverage of travel and medical fees for living-donor surgery and follow-up for non-resident donors to improve uptake of LDKT in immigrant patients, and provide KT education that is culturally competent, individually tailored and easily understandable for patients and their potential living donors.
Implementing primary care diabetes prevention for women with previous gestational diabetes: a mixed-methods study
Authors: O’Reilly Sharleen L , May Carl R , Ford Dale , Dunbar James A 
Published: March 2022

Abstract

Background
The implementation of diabetes prevention for women with previous gestational diabetes (GDM) has been stymied by many barriers that are located within routine general practice (GP). We aimed to unpack the GP factors and understand the mechanisms that explain why a diabetes prevention intervention for this population succeeds or fails.

Methods
We performed a mixed-methods study with a Normalization Process Theory framework that included clinical audits, semistructured interviews, and focus groups within mixed urban and rural primary care practices in Victoria, Australia. Staff of primary care practices and external support staff who provide services to women with previous GDM participated in a 12-month quality improvement collaborative intervention. We compared diabetes screening and prevention activity planning with the strategies and factors identified through a process evaluation of full-, moderate-, and low-active participating practices.

Results
The intervention doubled screening rates (26%–61%) and 1-in-10 women received a diabetes prevention planning consultation. Critical improvement factors were: mothers being seen as participants in the quality improvement work; staff collectively building care strategies; staff taking a long-term care of a community perspective rather than episodic service delivery; and feedback processes being provided and acted on across the practice. The observable factors from the external perspective were: leadership by identified practice staff, reminder systems in action and practice staff driving the process collectively.

Conclusions
Successful engagement in diabetes prevention for women with previous GDM requires proactive building of the critical improvement factors and audit feedback into routine GP.
Predictors, Types of Internet Use, and the Psychological Well-Being of Older Adults: A Comprehensive Model
Authors: Rosell Javiera , Vergés Alvaro , Miranda-Castillo Claudia , Sepúlveda-Caro Sofía , Gómez Macarena 
Published: March 2022

AbstractObjectivesThis study aims to evaluate a comprehensive model that includes predictors of use, types of Internet use, and psychological well-being outcomes in the older population.MethodsThe total sample comprised 650 older Internet users. Structural equation modeling was used to estimate the effect of predictors (i.e., effort expectancy, performance expectancy, social influence, and ageism) on types of Internet use (i.e., information seeking, communication, instrumental use, and leisure) and the impact of the type of use on the psychological well-being of older adults (i.e., depressive and anxious symptomatology). In addition, the indirect effect of different types of Internet use was evaluated, that is, they were considered as mediator variables.ResultsEffort expectancy, social influence, and ageism predicted different types of Internet use. The relationship between effort expectancy and anxious symptomatology had an indirect effect via information seeking, whereas the relationship between ageism and anxious symptomatology showed an indirect effect via leisure.DiscussionThe findings support the importance of differentiating the types of Internet use to understand its impact on psychological well-being. Information seeking is associated with anxious symptomatology and is predicted by effort expectancy. On the contrary, leisure is crucial because of its relationship with anxious symptomatology, and less ageism can promote it. This information is useful for developing effective interventions that promote the well-being of older adults through the Internet, including strategies to cope with some online challenges that could lead to negative consequences, such as information overload.
‘A cloister of curious workmanship’: the patronage of St. Stephen’s cloisters within the Palace of Westminster in the early sixteenth century
Authors: Biggs Elizabeth 
Published: March 2022

Abstract
A beautiful set of early sixteenth-century cloisters survive today within the nineteenth-century houses of parliament. Built for St. Stephen’s College, they have survived fire and bombs to become one of just three pre-modern survivals within the modern palace. Unlike the better-known Westminster Hall, the cloisters have received little attention because they have been offices for M.P.s and parliamentary staff. As there are no surviving building accounts, this article uses the institutional context and history that produced the cloisters, the design of the surviving vaulting and possible patronages to reassess a significant ecclesiastical project on the eve of the Reformation.
Crown-Presidentialism
Authors: Partlett William 
Published: March 2022

Abstract
This article will theorize a previously unidentified type of constitutional design that I call “crown-presidentialism.” Crown-presidential design combines constitutional powers exercised by elected presidents in both presidential and semi-presidential systems. First, as in presidentialism, crown-presidential constitutions grant the elected president final management power over the makeup of the executive-branch government. Second, as in a semi-presidentialism, crown-presidential constitutions afford the elected president guardian powers to control the legislative branch as well as important judicial, prosecutorial, and integrity institutions. This formal design has provided presidents an important tool for dominating both formal and informal politics while claiming fidelity to democratic constitutional design. Crown-presidentialism is therefore an important tool in the super-presidentialism of many new authoritarian regimes. This finding is a reminder of the importance of formal design rules in shaping political behavior—even in some forms of authoritarian governance.
Total arch replacement with the frozen elephant trunk technique for a right-sided aortic arch with a Kommerell diverticulum and aberrant right vertebral artery
Authors: Nagata Tomoki , Iwakoshi Shinichi , Yamada Takashi , Johno Hiroyuki 
Published: March 2022

Abstract
The best treatment for a right-sided aortic arch (RAA) and Kommerell diverticulum (KD) has not been determined due to the rarity of these conditions. The current trend in the treatment of this disease is to increase the endovascular approach without a sternotomy. We describe a rare condition with an association of an RAA with a KD of an aberrant left subclavian artery and an anomalous right vertebral artery originating from the aortic arch (AVA). The left vertebral artery was missing. Also, there was an incomplete circle of Willis due to the absence of the left and right posterior communication arteries. Therefore, the AVA was the only artery to supply the vertebral-basilar system. In our case, a simple thoracic endovascular aortic repair was not suitable because of the sharply curved arch and short landing zone. Also, a debranching thoracic endovascular aortic repair was not appropriate because that approach would not permit reconstruction of the AVA. The patient successfully underwent a total arch replacement with the frozen elephant trunk technique. This procedure could be an effective option for patients with RAAs with KDs associated with another arch vessel anomaly.
Kerler–Lyubashenko Functors on 4-Dimensional 2-Handlebodies
Authors: Beliakova Anna , De Renzi Marco 
Published: March 2022

Abstract
We construct a braided monoidal functor $J_4$ from Bobtcheva and Piergallini’s category $4\textrm {HB}$ of connected 4-dimensional 2-handlebodies (up to 2-deformations) to an arbitrary unimodular ribbon category $\mathscr {C}$, which is not required to be semisimple. The main example of target category is provided by ${H}\textrm{-mod}$, the category of left modules over a unimodular ribbon Hopf algebra $H$. The source category $4\textrm {HB}$ is freely generated, as a braided monoidal category, by a Bobtcheva--Piergallini Hopf (BPH) algebra object, and this is sent by the Kerler–Lyubashenko functor $J_4$ to the end $\int _{X \in \mathscr {C}} X \otimes X^*$ in $\mathscr {C}$, which is given by the adjoint representation in the case of ${H}\textrm{-mod}$. When $\mathscr {C}$ is factorizable, we show that the construction only depends on the boundary and signature of handlebodies and thus projects to a functor $J_3^{\sigma }$ defined on Kerler’s category $3\textrm {Cob}^{\sigma }$ of connected framed 3-dimensional cobordisms. When $H^*$ is not semisimple and $H$ is not factorizable, our functor $J_4$ has the potential of detecting diffeomorphisms that are not 2-deformations.
Effect of Plastic Mulch Colors on Anasa tristis (Hemiptera: Coreidae) Population Dynamics in Summer Squash, Cucurbita pepo (Cucurbitales: Cucurbitaceae)
Authors: Boyle Sean M , Alford Adam M , McIntyre Kelly C , Weber Donald C , Kuhar Thomas P 
Published: March 2022

Abstract
The squash bug, Anasa tristis (De Geer), is a serious pest of cucurbit crops across the United States, especially within summer squash (Cucurbita pepo L.) systems. Using their piercing sucking mouthparts, squash bugs feed on both leaf tissue and fruits, often leading to leaf necrosis, marketable fruit loss, and even plant death. To date, the relationship between squash bug presence and plasticulture has not been adequately investigated. This 2-yr study evaluated the effects of white, black, and reflective plastic mulch colors on the occurrence of all squash bug life stages and marketable zucchini yield in Virginia. In both years, A. tristis adults and egg masses were more numerous on zucchini plants grown in white and reflective plastic mulch compared to bare ground plants. Greater nymphal densities and marketable fruit yield were observed in certain plastic mulch treatments versus the bare ground treatment, yet these differences were not consistent in both years. Contrary to the repellency effects reflective mulches have on other cucurbit insect pests, our research suggests that reflective and other plastic mulch colors can negatively impact squash bug management, especially in regions with high A. tristis pressure. Our study offers new insights for cucurbit growers to use when considering whether they should implement plasticulture in their growing systems.
Fertility Effects on Blueberry Gall Midge (Diptera: Cecidomyiidae) in Wild Blueberry (Vaccinium angustifolium; Ericales: Ericaceae)
Authors: Gumbrewicz R , Calderwood L 
Published: March 2022

Abstract
Blueberry gall midge, Dasineura oxycoccana (Johnson) (Diptera: Cecidomyiidae) is a pest in American cranberry, Vaccinium macrocarpon Aiton (Ericales: Ericaceae) and wild blueberry, Vaccinium angustifolium Aiton (Ericales: Ericaceae), and has been observed in areas of high soil and foliar nutrient levels. New management strategies, including fertilization, will need to be altered to sustain wild blueberry production under climate change and, in turn, may impact the occurrence of this pest. The purpose of this study was to measure the effect of diammonium phosphate (DAP) fertilizer application on density of infested stems and the combined effects of fertilizer application with and without infestation on wild blueberry systems. This study was conducted at two field sites in Jonesboro and Washington, ME during 2020 and 2021. Despite increases in habitat availability (blueberry cover) for the gall midge and greater infestation density, wild blueberry production benefited from DAP application. This was shown in the number of buds per stem at both sites, as well as in stem height, flowers, green fruit, blue fruit per stem, and total yield at the Washington site. Foliar nitrogen and phosphorus levels had a significant positive linear relationship with infestation density. Growers applying fertilizers should monitor blueberry gall midge field infestation levels due to our findings that DAP fertilizer impacted infestation density and the interaction of DAP fertilizer with infestation impacted wild blueberry production.
Causation and the Legal Character of Command Responsibility after Bemba at the International Criminal Court
Authors: Jackson Miles 
Published: March 2022

Abstract
This article concerns the issue of causation under Article 28 of the Rome Statute of the International Criminal Court and the related foundational question of the legal character of command responsibility under that provision. It has two aims. First, it notes that across the proceedings in Bemba, judges were united in understanding command responsibility as a mode of liability. It then sets out four different positions on the question of causation in Bemba and argues that none is convincing — that none is able to escape the tensions that follow from that understanding of the legal character of command responsibility. Second, it suggests that the Court revisit that foundational understanding itself: it proposes that the Court interprets Article 28 as establishing a separate offence of omission and argues that such a reading of the Statute is plausible and attractive in principle and policy terms.
Choledochal cysts type VI: biliary cyst of the cystic duct with connecting to right anterior sectoral bile duct: a case report
Authors: Maneepairoj Nattaporn , Burasakarn Pipit , Thienhiran Anuparp , Fuengfoo Pusit , Linananda Sutdhachit , Hongjinda Sermsak 
Published: March 2022

Abstract
Type VI choledochal cysts or cystic duct dilatation cysts are a relatively new and rare condition. We report the case of a 35-year-old man who presented with a history of recurrent episodes of epigastrium pain. Magnetic resonance cholangiography revealed a cyst lodged between the cystic duct and the right anterior sectoral bile duct. He underwent a laparoscopic right anterior sectorectomy with cholecystectomy. Pathological examination revealed a cyst with a fibrous wall, dense chronic inflammatory infiltration, lined by columnar epithelium. Due to its rarity, the diagnosis is often made intraoperatively. The treatment of cystic duct cysts includes cholecystectomy, complete cyst excision, recontinuity of the common bile duct. Type VI choledochal cysts are extremely rare. Preoperative diagnosis, using either magnetic resonance cholangiopancreatography or endoscopic retrograde cholangiopancreatography, is vital to prevent postoperative complications. Treatment of this type of cysts includes cholecystectomy and complete cyst excision and biliary-enteric reconstruction if necessary.
Genetic analysis of early phenology in lentil identifies distinct loci controlling component traits
Authors: Rajandran Vinodan , Ortega Raul , Vander Schoor Jacqueline K , Butler Jakob B , Freeman Jules S , Hecht Valerie F G , Erskine Willie , Murfet Ian C , Bett Kirstin E , Weller James L 
Published: March 2022

Abstract
Modern-day domesticated lentil germplasm is generally considered to form three broad adaptation groups: Mediterranean, South Asian, and northern temperate, which correspond to the major global production environments. Reproductive phenology plays a key role in lentil adaptation to this diverse ecogeographic variation. Here, we dissect the characteristic earliness of the pilosae ecotype, suited to the typically short cropping season of South Asian environments. We identified two loci, DTF6a and DTF6b, at which dominant alleles confer early flowering, and we show that DTF6a alone is sufficient to confer early flowering under extremely short photoperiods. Genomic synteny confirmed the presence of a conserved cluster of three florigen (FT) gene orthologues among potential candidate genes, and expression analysis in near-isogenic material showed that the early allele is associated with a strong derepression of the FTa1 gene in particular. Sequence analysis revealed a 7.4 kb deletion in the FTa1–FTa2 intergenic region in the pilosae parent, and a wide survey of &gt;350 accessions with diverse origin showed that the dtf6a allele is predominant in South Asian material. Collectively, these results contribute to understanding the molecular basis of global adaptation in lentil, and further emphasize the importance of this conserved genomic region for adaptation in temperate legumes generally.
Genome-wide association mapping identifies an SNF4 ortholog that impacts biomass and sugar yield in sorghum and sugarcane
Authors: Upadhyaya Hari D , Wang Lihua , Prakash Chudamani Sharma , Liu Yanlong , Gao Li , Meng Ruirui , Seetharam Kaliyamoorthy , Gowda C L Laxmipathi , Ganesamurthy Kulandaivelu , Singh Shailesh Kumar , Kumar Rajendra , Li Jieqin , Wang Yi-Hong 
Published: March 2022

Abstract
Sorghum is a feed/industrial crop in developed countries and a staple food elsewhere in the world. This study evaluated the sorghum mini core collection for days to 50% flowering (DF), biomass, plant height (PH), soluble solid content (SSC), and juice weight (JW), and the sorghum reference set for DF and PH, in 7–12 testing environments. We also performed genome-wide association mapping with 6 094 317 and 265 500 single nucleotide polymorphism markers in the mini core collection and the reference set, respectively. In the mini core panel we identified three quantitative trait loci for DF, two for JW, one for PH, and one for biomass. In the reference set panel we identified another quantitative trait locus for PH on chromosome 6 that was also associated with biomass, DF, JW, and SSC in the mini core panel. Transgenic studies of three genes selected from the locus revealed that Sobic.006G061100 (SbSNF4-2) increased biomass, SSC, JW, and PH when overexpressed in both sorghum and sugarcane, and delayed flowering in transgenic sorghum. SbSNF4-2 encodes a γ subunit of the evolutionarily conserved AMPK/SNF1/SnRK1 heterotrimeric complexes. SbSNF4-2 and its orthologs will be valuable in genetic enhancement of biomass and sugar yield in plants.
Phytomelatonin as a central molecule in plant disease resistance
Authors: Zeng Hongqiu , Bai Yujing , Wei Yunxie , Reiter Russel J , Shi Haitao 
Published: March 2022

Abstract
Melatonin is an essential phytohormone in the regulation of many plant processes, including during plant development and in response to stress. Pathogen infections cause serious damage to plants and reduce agricultural production. Recent studies indicate that melatonin plays important roles in alleviating bacterial, fungal, and viral diseases in plants and post-harvest fruits. Herein, we summarize information related to the effects of melatonin on plant disease resistance. Melatonin, reactive oxygen species, and reactive nitrogen species form a complex loop in plant–pathogen interaction to regulate plant disease resistance. Moreover, crosstalk of melatonin with other phytohormones including salicylic acid, jasmonic acid, auxin, and abscisic acid further activates plant defense genes. Melatonin plays an important role not only in plant immunity but also in alleviating pathogenicity. We also summarize the known processes by which melatonin mediates pathogenicity via negatively regulating the expression levels of genes related to cell viability as well as virulence-related genes. The multiple mechanisms underlying melatonin influences on both plant immunity and pathogenicity support the recognition of the essential nature of melatonin in plant–pathogen interactions, highlighting phytomelatonin as a critical molecule in plant immune responses.