bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and risk factors for myocardial injury after laparoscopic adrenalectomy for pheochromocytoma: A retrospective cohort study
Authors: Lan Ling , Shu Qian , Yu Chunhua , Pei Lijian , Zhang Yuelun , Xu Li , Huang Yuguang 
Published: September 2022

BackgroundPheochromocytoma is a rare catecholamine-secreting tumor. Tumor resection remains a high-risk procedure due to intraoperative hemodynamic instability nowadays, which may lead to myocardial injury. We aimed to determine the incidence and associated risk factors for myocardial injury after laparoscopic adrenalectomy for pheochromocytoma.MethodsAdult patients (n=350, American Society of Anesthesiology physical status 1–3) who underwent elective laparoscopic adrenalectomy for pheochromocytoma under general anesthesia between January 31, 2013 and January 31, 2020 were included in this observational, retrospective, single-center, cohort study. Blood troponin I levels were measured before and during the first 2 days after surgery. Myocardial injury was defined as an elevated troponin I level exceeding the 99th percentile upper reference limit due to cardiac ischemic causes.ResultsMyocardial injury occurred in 42/350 patients (12.0%, 95% confidence interval: 9.0%–15.9%). In multivariable analysis (adjusted odds ratios [95% confidence intervals]), previous ischemic heart disease or stroke (5.04 [1.40–18.08]; P=0.013), intraoperative heart rate &gt;115 bpm (2.55 [1.06–6.12]; P=0.036), intraoperative systolic blood pressure &gt;210 mmHg (2.38 [1.00–5.66]; P=0.049), and perioperative decrease in hemoglobin level(1.74 [1.15–2.64] per g/dL decrease; P=0.008) were associated with an increased risk of myocardial injury. For the cumulative duration of dichotomized intraoperative hemodynamics, multivariable analysis showed that intraoperative heart rate &gt;115 bpm for &gt;1 minute (2.67 [1.08–6.60]; P=0.034) and systolic blood pressure &gt;210 mmHg for &gt;1 minute (3.78 [1.47–9.73]; P=0.006) were associated with an increased risk of myocardial injury. The risk of myocardial injury progressively increased with a longer cumulative duration of intraoperative tachycardia and hypertension.ConclusionsThere is a high incidence of myocardial injury after laparoscopic adrenalectomy for pheochromocytoma. The identified risk factors may assist physicians in detecting high-risk patients and providing guidance for intraoperative hemodynamics and perioperative hemoglobin management.
Proteomics unite traditional toxicological assessment methods to evaluate the toxicity of iron oxide nanoparticles
Authors: Han Junyuan , Tian Yongzhang , Wang Minghan , Li Yajuan , Yin Jiye , Qu Wensheng , Yan Changhui , Ding Rigao , Guan Yongbiao , Wang Quanjun 
Published: September 2022

Iron oxide nanoparticles (IONPs) are the first generation of nanomaterials approved by the Food and Drug Administration for use as imaging agents and for the treatment of iron deficiency in chronic kidney disease. However, several IONPs-based imaging agents have been withdrawn because of toxic effects and the poor understanding of the underlying mechanisms. This study aimed to evaluate IONPs toxicity and to elucidate the underlying mechanism after intravenous administration in rats. Seven-week-old rats were intravenously administered IONPs at doses of 0, 10, 30, and 90 mg/kg body weight for 14 consecutive days. Toxicity and molecular perturbations were evaluated using traditional toxicological assessment methods and proteomics approaches, respectively. The administration of 90 mg/kg IONPs induced mild toxic effects, including abnormal clinical signs, lower body weight gain, changes in serum biochemical and hematological parameters, and increased organ coefficients in the spleen, liver, heart, and kidneys. Toxicokinetics, tissue distribution, histopathological, and transmission electron microscopy analyses revealed that the spleen was the primary organ for IONPs elimination from the systemic circulation and that the macrophage lysosomes were the main organelles of IONPs accumulation after intravenous administration. We identified 197 upregulated and 75 downregulated proteins in the spleen following IONPs administration by proteomics. Mechanically, the AKT/mTOR/TFEB signaling pathway facilitated autophagy and lysosomal activation in splenic macrophages. This is the first study to elucidate the mechanism of IONPs toxicity by combining proteomics with traditional methods for toxicity assessment.
Topical nerve growth factor prevents neurodegenerative and vascular stages of diabetic retinopathy
Authors: Zerbini Gianpaolo , Maestroni Silvia , Leocani Letizia , Mosca Andrea , Godi Michela , Paleari Renata , Belvedere Arianna , Gabellini Daniela , Tirassa Paola , Castoldi Valerio , Viganò Ilaria , Galbiati Silvia , Turco Valentina , Lambiase Alessandro , Rama Paolo 
Published: September 2022

Specific and effective preventive treatment for diabetic retinopathy (DR) is presently unavailable, mostly because the early stages of the complication have been, until recently, poorly understood. The recent demonstration that the vascular phase of DR is preceded and possibly caused by the neurodegeneration of retinal ganglion cells suggests that DR could, at least theoretically, be prevented through an early neuroprotective approach. The aims of our study were to clarify the natural history of diabetes-driven retinal neurodegeneration and to verify the possibility to prevent DR using topical nerve growth factor (NGF). The results of the study show that retinal neurodegeneration, characterized by the loss of retinal ganglion cells represents a relatively early phenomenon of diabetes (between 5 and 16 weeks of age), which tends to be self-limiting in the long run. Neurodegeneration is followed by the development of DR-related vascular dysfunctions, as confirmed by the development of acellular capillaries and the loss of retinal pericytes. Both retinal neurodegeneration and subsequent vascular dysfunction can be successfully prevented by topical NGF administration. These findings suggest that: 1) The first stage of DR consists in a self-limiting retinal neurodegeneration 2) The demonstrated effectiveness of topical NGF in the prevention of DR could be rapidly translated into clinical practice.
GamReg Sweden—Protocol for a systematic cohort data collection for improved clinical knowledge in specialized gambling disorder treatment
Authors: Håkansson Anders , Åkesson Gunny 
Published: September 2022

BackgroundGambling disorder is the first non-substance-related addiction which is recognized as a diagnostic entity and assessed in treatment settings. However, in many clinical settings, assessment, and structured treatment for this condition is severely under-developed, and treatment seeking in many settings is low. This is a protocol paper describing the rationale and structure of a recently established quality register, allowing for structured monitoring of treatment seeking, treatment needs and treatment provision in Swedish health care settings, for gambling disorder and associated conditions.MethodsSince 2019, a Swedish quality register is in use for the systematic data collection from patients receiving treatment in specialized health care. The register is held by Region Skåne, and approved for national use. Swedish quality registers allow for the clinical monitoring of treatment uptake and needs, for quality improvement purposes, and collect systematic cohort data for these purposes. In addition, these quality registers potentially allow for future research projects, after separate ethics applications, allowing for clinical follow-up studies based on non-identified quality register data. Clinical challenges and research knowledge gaps are addressed in the present register, including mental health comorbidity, history of suicidal behavior, comorbid alcohol, drugs and gaming behaviors, and fundamental psycho-social variables such as violence victimization, concerned significant others including children's situation in families of problem gamblers, and main income and involvements with social services and enforcement agency. In addition, patient flows, including rates of referral from primary care and other treatment settings, can be followed. The overall quality register project is registered at clinicaltrials.gov (NCT05276193).DiscussionThe present protocol paper will allow for systematic reporting and future projects addressing knowledge gaps in clinical treatment for gambling disorder, and highlight the importance for evidence-based treatment in a behavioral addiction. Importantly, the current data will contribute to a better understanding of which patient groups may be less likely to seek or to be referred to treatment, and thereby may shape future initiatives to increase screening and referral in targeted, vulnerable groups.
Development and Evaluation of Strategies to Support Rural Secondments for Junior Physiotherapists
Authors: Van Balen Gabrielle , Smith Mitchell , Parish Laura , Gallagher Ryan Mark 
Published: September 2022

AbstractPurposeRural workforce shortages are a national issue. One strategy is the use of secondments from larger healthcare sites to staff rural sites on a rotational basis. The purpose of this evaluation is to explore the impact of the development, implementation of an educational, training and supervision package for junior Physiotherapists undertaking rural secondments in Northern NSW.Design/methodology/approachPre post evaluation of a training, education and supervision package to support junior Physiotherapists undertaking rural secondments across Northern NSW. A baseline survey of Physiotherapists who had undertaken a secondment in the previous 12 months defined current practice and limitations. From this a targeted education, training and supervision package was developed. Post implementation surveying for a period of 12 months was undertaken to evaluate the packages implementation.FindingsStatistically significant improvements in staff reporting they felt supported and were aware of escalation processes for patients under their care were reported. Additionally improvements were seen in staff reported access to and completing competencies relevant to their secondment.Research implicationsThese findings provide guidance in regards to junior Physiotherapists working on rural secondments and the importance of structured education, training and support mechanisms.Practical implicationsThe findings from this work support the development and implementation of structured education, training and supervision plans prior to undertaking rural secondments.Originality/valueThese findings provide evidence and support the need for structured and target training, education and supervision for staff undertaking rural secondments to ensure staff are confident to work in a rural setting.LimitationsLarger response rates for post implementation survey results may result in different outcomes being reported in comparison to pre implementation results.
MANAJEMEN KEUANGAN UMKM (USAHA MIKRO KECIL DAN MENENGAH) DI KOTA MEDAN
Authors: Faisal Faisal akbar 
Published: September 2022

Abstract

The ability and knowledge of small businesses to management science is very lacking, especially in the financial sector. Although most of these entrepreneurs have had formal education, not all of them have a financial management background. The purpose of this study was to find out ways to manage finances well by MSME actors (Micro, Small and Medium Enterprises). This study uses a descriptive and qualitative approach by means of documentation. The results obtained are that the first is mastery of financial statements by means of financial management by separating business finance and personal finance, determining the amount of financial percentage, carrying out financial records (bookkeeping), reducing the risk of accounts payable, and controlling the smooth flow of business cash, controlling the smooth flow of cash. business. And the financial reports required by MSMEs are certainly different from the financial reports for large companies. Seeing the complexity and smaller size of the business, the financial statements that need to be prepared become simpler both financial literacy in the form of financial skills as a technique for making decisions in financial management behavior and financial tools as a means used in making financial management decisions.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PENGAMBILAN KEPUTUSAN MENGGUNAKAN JASA OJEK ONLINE (GO-JEK)
Authors: Syahmanta Arbana 
Published: September 2022

Penelitian ini bertujuan untuk mengetahui pengaruh faktor-faktor yang mempengaruhi pengambilan keputusan menggunakan jasa ojek online (GO-JEK). Subjek penelitian yaitu pengguna go-jek di kawasan Sun plaza, Kampung Aur, Kecamatan Medan Polonia, teknik pengambilan semple menggunakan accidental sampling yang berjumlah 100 responden. Alat ukur yang digunakan adalah skala pengambilan keputusan yang disusun oleh peneliti berdasarkan faktor-faktor pengambilan keputusan yang terdiri dari 38 aitem dengan skor reliabilitas (α = 0.903). Berdasarkan analisis data, diperoleh hasil bahwa analisis faktor-faktor yang mempengaruhi pengambilan keputusan menggunakan jasa ojek online (GO-JEK). Pengambilan keputusan pengguna go-jek di kawasan Sun plaza, Kampung Aur, kecamatan Medan polonia, Berdasarkan hasil analisis faktor pengambilan keputusan pengguna GO-JEK didapatkan kontribusi faktor budaya terhadap pengambilan keputusan sebesar 0.879, faktor sosial sebesar 0.824, faktor pribadi sebesar 0.711 dan faktor psikologi sebesar 0.744. Ini menunjukan kontribusi faktor-faktor pengambilan keputusan yang ada dikategorikan memiliki kontribusi yang baik.
EFEKTIFITAS LAYANAN KONSELING INDIVIDUAL MENGGUNAKAN PENDEKATAN EKLEKTIK UNTUK MENGATASI EMOSIONAL SISWA KELAS X SMK BINA SATRIA MEDAN TAHUN PEMBELAJARAN 2016/2017
Authors: Nauli Fauziah Harahap Sri Ngayomi Yudha Wastuti 
Published: September 2022

Konseling individual merupakan pertemuan konselor dengan konseli secara individual, dimana terjadi hubungan konseling yang bernuansa rapport, dan konselor berupaya memberikan bantuan untuk mengembangkan pribadi konseli serta konseli dapat mengantisipasi masalah-masalah yang dihadapinya. Konseling individual yang di berikan kepada peserta didik (konseli) difokuskan kepada sikap dan tingkah lakunya yang kemudian setelah pelaksanaannya peserta didik (konseli) mengalami perubahan positif yang diharapkan sebagai hasil dari pelaksanaan konseling individual. Emosional merupakan setiap kegiatan atau pengelolaan pikiran, perasaan, nafsu, setiap keadaan mental yang hebat dan meluap-luap yang dialami individu. Penelitian ini dilaksanakan di SMK Bina Satria Medan yang beralamat di Jalan Marelan IX, No. 1, Kel. Tanah Enam Ratus, Kec. Medan Marelan, Kota Medan, Provinsi Sumatera Utara. Subjek dalam penelitian ini adalah Kepala Sekolah, Guru Bimbingan dan Konseling, Guru Bidang Studi, Wali Kelas, dan Siswa yang berjumlah 5 orang sesuai dengan rekomendasi dari Guru Bimbingan dan Konseling. Adapun Objek dalam penelitian ini adalah Efektifitas Layanan Konseling Individual Menggunakan Pendekatan Eklektik Untuk Mengatasi Emosional Siswa Kelas X SMK Bina satria Medan. Penelitian ini merupakan penelitian Kualitatif. Berdasarkan hasil data dan interpretasi data yang peneliti lakukan dapat disimpulkan bahwa konseling individual dapat mengatasi emosional siswa kelas X mengingat pada usia remaja siswa masih mengalami ketidakstabilan emosi. Oleh karena itu untuk mengatasi hal tersebut perlu perhatian khusus dan mendalam melalui konseling individual.
TENDENCY OF VICTIM BULLYING BASED ON ASSERTIVE BEHAVIOR BY STUDENTS OF SMA SWASTA RAKSANA MEDAN
Authors: Ngalem Dwi Ezra 
Published: September 2022

This study aims to determine the relationship between assertive behavior and tendency of victim bullying. The hypothesis of this study states that there is a negative relationship between assertive behavior and tendency of victim bullying, with the assumption that the higher the assertive behavior, the lower tendency of victim bullying, and conversely the lower the assertive behavior, the higher tendency of victim bullying. The subjects of this study were high school 105 students of SMA Swasta Raksana Medan. Data were obtained from a scale to measure assertive behavior and tendency of victim bullying.. The calculation was performed using test requirements analysis (assumption), which consists of normality distribution test and linearity relationship test. Data were analyze by Product Moment Correlation with SPSS 19 for windows. The results of data analysis showed that the correlation coefficient was -0.209 (p <0.05). It showed that there is a negative relationship between assertive behavior and tendency of victim bullying. These results indicate that the contributions of assertive behavior variable to tendency of victim bullying was at 4,4 percent, while the remaining 95,6 percent is influenced by other factors not examined. From these results it is concluded that the hypothesis stating there is a negative relationship between assertive behavior and tendency of victim bullying is acceptable.
KOMUNIKASI, DISIPLIN DAN LINGKUNGAN KERJA MEMPENGARUHI KINERJA PEGAWAI
Authors: Ariani Misna , Tamara Dwinda , Misnah Misnah 
Published: September 2022

ABSTRAK

Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh komunikasi, disiplin, dan lingkungan kerja terhadap kinerja Pegawai Badan Keuangan dan Aset Daerah Kabupaten Penajam Paser Utara. Jumlah pegawai 62 orang, dengan motode sensus maka semua pegawai menjadi responden. Pengumpulan data dilakukan dengan penyebaran kuesioner. Data diuji dengan regresi linier berganda.
Hasil uji menunjukkan bahwa secara simultan komunikasi, displin dan lingkungan kerja berpengaruh positif dan signifikan. Secara parsial komunikasi, disiplin dan lingkungan kerja berpengaruh positif dan signifikan. Namun, lingkungan kerja berpengaruh positif tapi tidak signifikan terhadap kinerja pegawai. Dan, disiplin berpengaruh dominan terhadap kinerja Pegawai Badan Keuangan dan Aset Daerah Kabupaten Penajam Paser Utara.
ANALISIS DETERMINAN KEMISKINAN DI JAWA TIMUR TAHUN 2018
Authors: Yuwono Yudo Nugroho Ris , Janahtul Isnaini Sofia Janahtul Isnaini 
Published: September 2022

Poverty is a multidimensional concept that includes dimensions as lack of opportunity, lack of empowerment, and lack of security. This study aims to analyze the determinants of poverty and their effects on poverty in East Java Province. This research uses quantitative methods, and the data used are data from the Central Statistics Agency of East Java Province. The type of data used is a cross-section in 2018. This study uses multiple linear analysis (OLS) with poverty as the dependent variable, economic growth (GRDP), labor force, and APBD as independent variables. It uses regional dummy variables to see the effect of poverty enclaves on poverty in East Java. Dummy 1 for the “tapal kuda” area, and dummy 2 for the Madura island area. The results showed that the GRDP and regional budget had a negative and significant effect on poverty. Labor force variables have a positive and significant impact on poverty in East Java Province in 2018. Dummy 1 (D1) has a probability of 0.6532 (> 0.05), which means that the D1 variable is not significant to poverty in East Java. Then for the D2 variable or region on the island of Madura has a probability level of 0.0233 (<0.05), which means significant for poverty in East Java in 2018
ANALISIS PENERAPAN MODEL PURCHASING POWER PARITY UNTUK MEMPREDIKSI NILAI TUKAR RUPIAH TERHADAP US DOLLAR (Periode Januari 2016 – Desember 2018)
Authors: Tamonsang Matheous , Arochman Maqbulla 
Published: September 2022

ABSTRACT

This study aims to test the ability of the purchasing power parity model used to predict the exchange rate of the rupiah against the US dollar based on differences in inflation in the two countries. Determination of the sample in this study using purposive sampling method by time series per month during the period January 2016 - December 2018 as many as 36 months. The results of this study are that first, the difference in inflation rates in Indonesia and the United States has a significant effect on changes in the US Dollar exchange rate. Second, the purchasing power parity model is still feasible to be used to predict the rupiah exchange rate against the US dollar. These results are shown by the significant effect of differences in inflation in the two countries on changes in exchange rates, supported by the regression results of purchasing power parity that meet the requirements of the assumption test.

Keywords: Purchasing Power Parity, Rupiah, Dollar, Inflation
ANALISIS STRUKTUR MODAL PERUSAHAAN MAKANAN DAN MINUMAN MELALUI PERTUMBUHAN PENJUALAN DAN TARIF PAJAK
Authors: Linda Marlindawaty 
Published: September 2022

ABSTRAK
Struktur modal merupakan suatu hal yang sangat penting bagi suatu perusahaan terutama untuk keuangan dan nilai perusahaan sehingga manajer keuangan harus memahami faktor-faktor yang mempengaruhi struktur modal agar dapat memaksimalkan kemakmuran para pemegang saham perusahaan. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana pengaruh pertumbuhan penjualan dan tarif pajak terhadap struktur modal pada perusahaan makanan dan minuman yang terdaftar di Bursa Efek Indonesia (BEI) periode 2013-2017. Penelitian ini menggunakan leverage sebagai proksi dari struktur modal. Analisis regresi yang digunakan adalah analisis regresi linier berganda. Berdasarkan pembahasan hasil penelitian, pertumbuhan penjualan berpengaruh signifikan terhadap struktur modal dan tarif pajak tidak berpengaruh terhadap struktur modal pada perusahaan makanan dan minuman.
Kata Kunci : Struktur Modal, Pertumbuhan Penjualan, Tarif Pajak
ABSTRACT
Capital structure is a very important for a company, especially for finance and company value, so that financial managers must understand the factors that influence the capital structure in order to maximize the prosperity of the company’s shareholders. The purpose of this research was to find out how the effect of sales growth and tax rate on the capital structure of food and beverages companies listed on the Indonesia Stock Exchange for the period 2013-2017. This research uses leverage as a proxy of the capital structure. The regression analysis used is multiple linear regression analysis. Based on the discussion of the results of the research, the sales growth has a significant effect on the capital structure and the tax rate has no effect on the capital structure of the food and beverages companies.
Keywords : Capital Structure, Sales Growth, Tax Rate
EVALUASI KINERJA TENAGA PENDIDIK MELALUI CLASSROOM ACTION RESEARCH
Authors: Ariani Hj. Misna Ariani 
Published: September 2022

Artikel ini, merupakan penelitian/evaluasi terhadap kinerja tenaga pendidik (dosen) ditinjau dari action research. Evaluasi dosen dilakukan terhadap kegiatan belajar mengajar mahasiswa A1 Program Studi Manajemen Fakultas Ekonomi Universitas Balikpapan, selama 1 semester (6 bulan). Tujuan dari penelitian/evaluasi ini adalah untuk mengetahui kinerja dosen melalui: 1. Kegiatan belajar mengajar, 2. Kehadiran dosen. 3. Kemampuan mahasiswa dalam mengimplementasikan dalam bentuk presentasi di kelas. Data untuk mengevaluasi merupakan aktivitas belajar mengajar selama 16 kali pertemuan selama 1 semester. Data berupa kegiatan mahasiswa dalam perkuliahan dan kehadiran dosen di dalam kelas. Perkuliahan saat pandemic covid-19 berbeda dengan saat sebelum ada pandemic. Sebelum pandemic perkuliahan dilakukan dikelas dengan cara tatap muka dan aksi kelas, sedangkan pada saat pandemic perkuliahan tetap dengan cara tatap muka tetapi tidak di dalam kelas langsung, namun menggunakan aplikasi Zoom. Hasil penelitian menunjukkan bahwa kehadiran mahasiswa tetap tinggi (rata-rata, 15 kali tatap muka) jumlah kehadirannya, Kehadiran dosen tetap seperti saat tatap muka di kelas secara langsung, Mahasiswa mampu menyerap materi kuliah, dengan bukti mampu mempresentasikan matakuliah yang ditempuh, yaitu Seminar MSDM.