bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is the Concept, Method, or Measurement to Blame for Testing Error? An Illustration Using the Force-Velocity-Power Profile
Authors: Samozino Pierre , Rivière Jean Romain , Jimenez-Reyes Pedro , Cross Matt R. , Morin Jean-Benoît 
Published: November 2022

When poor reliability of “output” variables is reported, it can be difficult to discern whether blame lies with the measurement (ie, the inputs) or the overarching concept. This commentary addresses this issue, using the force-velocity-power (FvP) profile in jumping to illustrate the interplay between concept, method, and measurement reliability. While FvP testing has risen in popularity and accessibility, some studies have challenged the reliability and subsequent utility of the concept itself without clearly considering the potential for imprecise procedures to impact reliability measures. To this end, simulations based on virtual athletes confirmed that push-off distance and jump-height variability should be <4% to 5% to guarantee well-fitted force–velocity relationships and acceptable typical error (<10%) in FvP outputs, which was in line with previous experimental findings. Thus, while arguably acceptable in isolation, the 5% to 10% variability in push-off distance or jump height reported in the critiquing studies suggests that their methods were not reliable enough (lack of familiarization, inaccurate procedures, or submaximal efforts) to infer underpinning force-production capacities. Instead of challenging only the concept of FvP relationship testing, an alternative conclusion should have considered the context in which the results were observed: If procedures’ and/or tasks’ execution is too variable, FvP outputs will be unreliable. As for some other neuromuscular or physiological testing, the FvP relationship, which magnifies measurement errors, is unreliable when the input measurements or testing procedures are inaccurate independently from the method or concept used. Field “simple” methods require the same methodological rigor as “lab” methods to obtain reliable output data.
Development of a core outcome set on Traditional Chinese Medicine andWestern Medicinefor rheumatic heart disease: a study protocol
Authors: Sheng Xiaodi , Chen Chao , Ji Zhaochen , Hu Haiyin , Zhang Mingyan , Wang Hui , Pang Bo , Zhai Jingbo , Zhang Dong , Zhang Junhua , Guo Liping 
Published: November 2022

IntroductionGlobally, rheumatic heart disease (RHD) is an important cause of acquired heart disease in children and adolescents. Clinical trials on RHD treatment with Traditional Chinese Medicine (TCM) or integrated medicine are gradually increasing in China. However, because the outcomes of clinical trials are subject to heterogeneity and selective reporting, similar studies cannot be merged and compared, complicating assessing the effectiveness and safety of TCM, and diminishing the value of clinical trials. Therefore, there is an urgent need to design a TCM or integrated medicine core outcome set (COS) for RHD.Methods and analysisThe development of this study will take place in four stages under the direction of a multidisciplinary advisory board. (1) Establishing a comprehensive outcomes checklist through a systematic review of previously published research, retrieval of clinical trial registration centres, patient’s semistructured interviews, and clinician’s questionnaire surveys; (2) Screen stakeholder groups from various fields to participate in the Delphi survey; (3) Two e-Delphi surveys will be conducted to determine the outcomes of various concerned stakeholder groups; (4) Hold a face-to-face consensus meeting to develop the COS-TCM-RHD.Ethics and disseminationThe ethical approval for this study has been obtained from the Tianjin University of Traditional Chinese Medicine Ethics Committee (TJUTCM-EC20210008). The findings will be disseminated in peer-reviewed journals and meetings.Trial registration numberThis study has been registered at the Core Outcome Measures in Effectiveness Trials (COMET) database (Registration #1743).
Assessment of sex-related differences and outcome in patients who underwent cryoballoon pulmonary vein isolation for atrial fibrillation: an observational cohort study
Authors: Ekrami Neda Khalilian , Magni Federico T , Dayalani Vijay , van Gelder Isabelle C , Groenveld Hessel F , Tieleman Robert G , Wiesfeld Ans CP , Tan Eng S , Rienstra Michiel , Blaauw Yuri , Mulder Bart A 
Published: November 2022

ObjectivesPulmonary vein isolation (PVI) is widely accepted as an effective and safe treatment for symptomatic atrial fibrillation (AF). However, data on sex-related differences and associations with clinical outcome and safety of PVI with cryoballoon ablation are limited. We sought to compare sexrelated efficacy and safety of cryoballoon ablation and identify sex-related associations with clinical outcomes.Methods and resultsWe included 650 consecutive patients with AF undergoing PVI with cryoballoon ablation at our institution between 2013 and 2017. The efficacy outcome was the first documented recurrence (>30 s) of AF, atrial flutter or atrial tachycardia (AF/AT) or repeat ablation during follow-up, after a 90-day blanking period. The safety outcome was the incidence of periprocedural complications. Mean age of the population was 58±10, and 210 (32.3%) patients were women. Women were older, had a higher body mass index, had more renal dysfunction and less coronary artery disease as compared with men. The rate of AF/AT recurrence was similar between women and men at 12-month follow-up (27.6% vs 24.8%, p=0.445). The incidence of periprocedural complications was higher in women (12.9% vs 4.6%; p<0.001), specifically groin haematomas and phrenic nerve palsy. On multivariate analysis, left atrial volume index (adjusted OR 1.05, 95% CI 1.00 to 1.10; p=0.032) was associated with the incidence of procedural complications in women. For men, no relation with complications could be found.ConclusionThe efficacy of cryoballoon ablation was similar between women and men; however, women had a higher risk of procedural complications.
Gauge invariant massive vector Kaluza–Klein modes of U(1)gauge field in braneworld
Authors: Fu Chun-E 
Published: November 2022

AbstractIt was found that in a RS-like brane model the effective action for the massive vector KK modes of a U(1) gauge field was gauge invariant Fu et al., JHEP 2019(1) (2019). https://doi.org/10.1007/jhep01(2019)021. It is interesting to investigate the factors this gauge invariance maybe depend on, such as the geometry of the space-time, the number of the extra dimensions, and the dimension of the brane. We demonstrate that the three factors do not affect the gauge invariant formulation of the effective action, but influence the localization of the gauge invariant massive vector KK modes.
A conformally invariant Yang–Mills type energy and equation on 6-manifolds
Authors: Gover A. Rod , Peterson Lawrence J. , Sleigh Callum 
Published: November 2022

We define a conformally invariant action [Formula: see text] on gauge connections on a closed pseudo-Riemannian manifold [Formula: see text] of dimension 6. At leading order this is quadratic in the gauge connection. The Euler–Lagrange equations of [Formula: see text], with respect to variation of the gauge connection, provide a higher-order conformally invariant analogue of the (source-free) Yang–Mills equations. For any gauge connection [Formula: see text] on [Formula: see text], we define [Formula: see text] by first defining a Lagrangian density associated to [Formula: see text]. This is not conformally invariant but has a conformal transformation analogous to a [Formula: see text]-curvature. Integrating this density provides the conformally invariant action. In the special case that we apply [Formula: see text] to the conformal Cartan-tractor connection, the functional gradient recovers the natural conformal curvature invariant called the Fefferman–Graham obstruction tensor. So in this case, the Euler–Lagrange equations are exactly the “obstruction-flat” condition for 6-manifolds. This extends known results for 4-dimensional pseudo-Riemannian manifolds where the Bach tensor is recovered in the Yang–Mills equations of the Cartan-tractor connection.
Venice Was Flooding ... One Tweet at a Time
Authors: Lorini Valerio , Rufolo Paola , Castillo Carlos 
Published: November 2022

Before urban flooding actually happens, weather forecasts with varying degrees of precision are available to emergency managers. In the aftermath of the event, authoritative information including Earth Observation (EO) data can be used to estimate precisely the flood extent, possibly after several hours. This study aims to determine how social media information can reduce the inherent uncertainty of the information in the immediate aftermath of an urban flood event. Specifically, the study investigates how to collect relevant social media images and to interpolate such data in order to create a map.
The premise of the study is that social media platforms, when combined with digital surface models, can provide control points for creating a reliable near real-time estimate of the flood extent. In the study, we compared a flood extent map derived from social media with that derived from authoritative altimetry data during one of the worst floods to hit Venice, which occurred in November 2019.
The results of the experiments show a good overall accuracy using several digital surface models. Given the global coverage of such models and the low resources required, we think the methodology proposed could be beneficial for emergency managers. Specifically, we describe how a flood extent map can be made available within 24 h, or even less, after urban flooding strikes a densely inhabited area, where data generated by the public are available.
Plasma Concentrations of Gut Hormones Acyl Ghrelin and Peptide YY and Subsequent Risk of Colorectal Cancer and Molecular Tumor Subtypes
Authors: Bodén Stina , Harbs Justin , Sundkvist Anneli , Fuchs Klara , Myte Robin , Gylling Björn , Zingmark Carl , Löfgren Burström Anna , Palmqvist Richard , Harlid Sophia , Van Guelpen Bethany 
Published: November 2022

Abstract

Obesity and metabolic dysfunction are implicated in colorectal cancer development. Appetite-regulating gut hormones might have a role in colorectal cancer risk. We investigated whether circulating levels of the gut hormones ghrelin (analyzed as acyl ghrelin) and Peptide YY (PYY) were associated with subsequent colorectal cancer risk, including clinical and molecular tumor subtypes. We also provide descriptive data on these hormones in relation to background participant characteristics and metabolic biomarkers. This population-based study included 1,010 matched case–control pairs with a median of 12.3 years of follow-up. Acyl ghrelin and PYY were measured by multiplex immunoassay. Data on KRAS and BRAF mutations and microsatellite instability (MSI) status were available for 704 and 708 cases, respectively. Conditional logistic regression models estimated association to colorectal cancer risk. Partial correlation and linear regression were used to investigate relationships between background and metabolic variables and variation in plasma gut hormone concentrations. Acyl ghrelin was not clearly associated with colorectal cancer risk (multivariable OR per 1 SD increase: 1.11; 95% CI, 1.00–1.23). Positive associations were observed for specific subtypes, in particular BRAF-mutated colorectal cancer and right-sided colon cancer, although with nonsignificant heterogeneity. PYY was not related to colorectal cancer risk (multivariable OR per 1 SD: 1.04; 95% CI, 0.95–1.14) or any tumor subtype. In the control participants, ghrelin was inversely correlated with BMI, and PYY was positively correlated with C-peptide and insulin levels. These findings provide limited support for a possible role for ghrelin in colorectal cancer development, primarily in specific anatomical and molecular tumor subtypes.

Prevention Relevance:
The findings of this study do not support a major role for the metabolic gut hormones ghrelin and PYY in colorectal cancer development but suggest the possibility of an involvement for ghrelin in specific tumor subtypes. Elucidating subtype-specific risk factors and mechanisms of carcinogenesis may have implications for precision prevention.
Description of two new species of Xenocona Gilmour (Coleoptera, Cerambycidae, Lamiinae) from Ecuador
Authors: Vlasak Josef , Santos-Silva Antonio 
Published: November 2022

Xenocona Gilmour, 1960 (Acanthocinini) includes seven species distributed through Central America and northern South America. Here we describe two new species from Ecuador: X. audureaui (differing from other species of the genus by the presence of large dark macula on dorsal surface of the basal ⅔ of the elytra combined with the absence of narrow white pubescent lines on other areas of the elytra) and X. uniformis (differing from the other species of the genus by the spiniform outer elytral angle).
A taxonomic review of the vampire catfish genus Paracanthopoma Giltay, 1935 (Siluriformes, Trichomycteridae), with descriptions of nine new species and a revised diagnosis of the genus
Authors: De Pinna Mário César Cardoso , Dagosta Fernando Cesar Paiva 
Published: November 2022

A taxonomic revision is presented of the genus Paracanthopoma, probably the least-known vandelliine genus at present. The work is based on most of the material available in museums worldwide and includes a major expansion in the knowledge about the genus. Paracanthopoma is circumscribed as a monophyletic group on the basis of nine putatively synapomorphic characters. Evidence is provided for Paracanthopoma and Paravandellia as sister groups and the two genera are comparatively diagnosed. A total of 13 species are recognized in Paracanthopoma, of which nine are new and one is transferred from Paravandellia: Pc. ahriman, new species, Pc. alleynei (Henschel et al., 2021), Pc. carrapata, new species, Pc. cangussu Henschel et al., 2021, Pc. capeta, new species, Pc. daemon, new species, Pc. irritans, new species, Pc. malevola, new species, Pc. parva Giltay, 1935, Pc. saci Dagosta & de Pinna, 2021, Pc. satanica, new species, Pc. truculenta, new species, and Pc. vampyra, new species. Different species display a high degree of phenotypic divergence and are diagnosed on the basis of traditional as well as new morphological characters of both external and internal anatomy. Geographical distributions are mapped for each species and an identification key is provided. Preliminary evidence suggests the existence of four main subclades within Paracanthopoma. The first one includes Pc. ahriman, Pc. cangussu, and Pc. irritans. A second subclade comprises Pc. carrapata, Pc. daemon, Pc. parva, and Pc. truculenta. A third clade includes Pc. malevola and Pc. satanica and a fourth comprises Pc. alleynei and Pc. vampyra. The last clade lacks some putative synapomorphies of all other members of Paracanthopoma and seems to be the sister group to the rest of the genus. Relationships of Pc. capeta and Pc. saci are not as clear, but some evidence exists for the former being related to the first subclade and the latter to the second subclade.
RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function
Authors: Akerberg Alexander A. , Trembley Michael , Butty Vincent , Schwertner Asya , Zhao Long , Beerens Manu , Liu Xujie , Mahamdeh Mohammed , Yuan Shiaulou , Boyer Laurie , MacRae Calum , Nguyen Christopher , Pu William T. , Burns Caroline E. , Burns C. Geoffrey 
Published: November 2022

Background:
RBPs (RNA-binding proteins) perform indispensable functions in the post-transcriptional regulation of gene expression. Numerous RBPs have been implicated in cardiac development or physiology based on gene knockout studies and the identification of pathogenic RBP gene mutations in monogenic heart disorders. The discovery and characterization of additional RBPs performing indispensable functions in the heart will advance basic and translational cardiovascular research.

Methods:

We performed a differential expression screen in zebrafish embryos to identify genes enriched in
nkx2.5
-positive cardiomyocytes or cardiopharyngeal progenitors compared to
nkx2.5
-negative cells from the same embryos. We investigated the myocardial-enriched gene RNA-binding protein with multiple splicing (variants) 2 [
RBPMS2
)] by generating and characterizing
rbpms2
knockout zebrafish and human cardiomyocytes derived from
RBPMS2
-deficient induced pluripotent stem cells.

Results:

We identified 1848 genes enriched in the
nkx2.5
-positive population. Among the most highly enriched genes, most with well-established functions in the heart, we discovered the ohnologs
rbpms2a
and
rbpms2b
, which encode an evolutionarily conserved RBP. Rbpms2 localizes selectively to cardiomyocytes during zebrafish heart development and strong cardiomyocyte expression persists into adulthood. Rbpms2-deficient embryos suffer from early cardiac dysfunction characterized by reduced ejection fraction. The functional deficit is accompanied by myofibril disarray, altered calcium handling, and differential alternative splicing events in mutant cardiomyocytes. These phenotypes are also observed in RBPMS2-deficient human cardiomyocytes, indicative of conserved molecular and cellular function. RNA-sequencing and comparative analysis of genes mis-spliced in RBPMS2-deficient zebrafish and human cardiomyocytes uncovered a conserved network of 29 ortholog pairs that require
RBPMS2
for alternative splicing regulation, including
RBFOX2, SLC8A1
, and
MYBPC3
.

Conclusions:

Our study identifies
RBPMS2
as a conserved regulator of alternative splicing, myofibrillar organization, and calcium handling in zebrafish and human cardiomyocytes.
Mechanical Thrombectomy in Basilar Artery Stroke Attributable to Persistent Primitive Proatlantal Intersegmental Artery: A Case Report
Authors: Sharma Pankaj , Kandregula Sandeep , Barry James , Cuellar Hugo 
Published: November 2022

ObjectiveThis clinical note describes a patient who presented with acute basilar artery occlusion and a persistent primitive proatlantal artery.Case PresentationWe present the case of an 82‐year‐old woman who presented with sudden onset of left‐sided weakness. Cross‐sectional imaging revealed occlusion of the basilar artery with a persistent primitive proatlantal artery. She then underwent successful mechanical thrombectomy. Complete reperfusion was achieved; thereafter, she recovered well from the ischemic stroke and was discharged home. Discharge modified Rankin Scale score was <2.ConclusionThis is the first case report of mechanical thrombectomy in a patient with persistent primitive proatlantal artery. Embryonic carotid vertebral anastomosis rarely persists in adult patients. Prompt and accurate recognition of these persistent embryonic anastomoses is of paramount importance in interpreting cross‐sectional imaging and planning revascularization procedures.
Ordained Ministry: Divine Calling or Career Choice? Is there Anything Distinctive About a Vocation to Ordained Ministry?
Authors: Lovell Cara 
Published: November 2022

Abstract
This article addresses current ambiguities and potential confusion around the language and nature of vocation to ordination, focusing specifically on the process by which that vocation is discerned by the individual and by the church. It suggests that the particular shape of ordained ministry differentiates the process of vocational discernment to ordination from career choice. Drawing on the Ordination rite of the Church of England, the distinctive Christological, pneumatological and ecclesial elements of ordained ministry are expounded and offered as a theological framework for articulating and discerning a call to ordained ministry. Although the focus of this article is on vocational discernment for ordained ministry within the Church of England, the theological framework presented will be of wider relevance as churches reflect on how they identify those whom God is calling to ordained ministry and on how this may be constructively communicated with those who are discerning this vocation.
Primitive Model of Partitive Division: A Replication of the Fischbein et al. Study
Authors: Giberti Chiara , Maffia Andrea 
Published: November 2022

Abstract
We present a replication study of one of the most renowned seminal works in the field of mathematics education, i.e., the Fischbein et al. (1985) study on implicit models of multiplication and division in solving word problems. The original instrument was administered to a sample of 902 grade 7 students, proposing some methodological variations. The discussion focuses on four items involving partitive division of integer numbers, and results are compared to the original study: the main results of the original study are confirmed, but we contribute further with considerations on the statistical significance of differences observed in item difficulty. Finally, through our new methodological approach, we broaden the results of the original study by analysing students’ behaviour on the basis of their general arithmetical problem-solving ability. Students with medium-level ability are more influenced by the primitive model than those with lower ability.
“Dove terra ha cielo”. Il teatro di Enrico Pea e la favola del Cristo incantatore
Authors: Golia Francesca 
Published: November 2022

Questo articolo intende esplorare la dimensione del sacro nell’ambito della produzione teatrale di Enrico Pea, colmando, in tal modo, una lacuna negli studi dedicati all'autore toscano. Tale tema sarà affrontato attraverso il prisma della rappresentazione di Gesù Cristo, conferendo un rilievo particolare alla dimensione dello scandalo, al fine di far emergere la presenza di una duplice dialettica: tra conoscenza e immaginazione, tra dogma della fede e libertà della favola. This article aims to explore the dimension of the sacred within the theatrical production of Enrico Pea, fulfilling, as a result, a lacuna in the studies dedicated to the Tuscan author. This theme will be approached through the prism of the representation of Jesus Christ, with special emphasis on the dimension of scandal, in order to bring out the presence of a dual dialectic: between knowledge and imagination, between the dogma of faith and the freedom of fable.