bluuebunny/crossref_metadata_2025_split huggingface dataset:
El agente secreto de Torrijos Francisco de Unzaga Saint Maxent (1788-1849), presidente de la Junta Liberal
Authors: Cazorla Granados Frank J. , García Baena Rosa María 
Published: March 2022

El coronel malagueño Francisco de Unzaga, hijo del gobernador Luis de Unzaga, se había formado en la Escuela de Pajes, donde coincidió con los futuros generales masones Van Halen, Manzanares y López Pinto, todos de su misma edad, y con Torrijos, que era de la generación de su hermano. Unzaga fue uno de los que recibieron al rey José I a su entrada en Málaga. Tras la persecución que sufrieron sus familiares —entre ellos su hermano Mariano, quien marchó a Estados Unidos exiliado acompañando al monarca masón José Bonaparte—, Francisco será de los pocos que sobrevivan y, además de ser comandante de las milicias urbanas de Málaga, ocupará la presidencia de la Junta Liberal clandestina, convirtiéndose, por tanto, en corresponsal secreto de primer orden que participará en varios de los intentos por lograr la democracia, tales como la expedición del general Manzanares en Estepona y poco después del general Torrijos. Años más tarde, Francisco pudo escaparse de la represalia absolutista y acabó luchando contra los carlistas en defensa de Isabel II, restableciéndose así su servicio a una corona borbónica más parlamentaria. Su vida es paradigmática de un liberal de la primera mitad del siglo XIX digno de ser recordado.
La cosmopolita Isabel Saint Maxent de Unzaga, filántropa y mecenas de la educación ilustrada
Authors: García Baena Rosa , Cazorla Granados Frank J. 
Published: March 2022

Perfilar la biografía de Isabel Saint Maxent de Unzaga es adentrarse en el devenir vital público y privado de una mujer criolla, proveniente de una acaudalada e influyente familia de origen francés en la Luisiana española, en el contexto general de las revoluciones atlánticas y del nacimiento de los Estados Unidos de América en 1776. Isabel ocupará una posición privilegiada como consorte de un destacado hombre de Estado que representaba a la corona española, Luis de Unzaga, gobernador de Luisiana y que luego va a seguir ocupando cargos muy importantes en Nueva España. En Cuba, en el intermedio entre el fin de la guerra de la Independencia y la firma del Tratado de Paz con Inglaterra en 1783, Isabel, junto a su marido, capitán general, con dotes de diplomacia internacional, recibirá la visita del príncipe William, futuro rey de Inglaterra. Como esposa de un gobernante ilustrado, Isabel desarrollará una labor filantrópica en pro de la educación no solo en el ámbito familiar, sino también promoviendo la creación de las primeras escuelas públicas bilingües, la Sociedad de Damas de Málaga y la del cuidado de niños expósitos; además, una vez que enviudó, administró el importante patrimonio familiar.
Evaluation of the tRNA-Leu (UUR) gene haplotype profile observed in canine mammary gland tumours based on comparative analysis with the MT-TL1 human gene
Authors: Kowal Krzysztof , Tkaczyk-Wlizło Angelika , Pierzchała Mariusz , Ślaska Brygida 
Published: March 2022

Abstract
The aetiology and pathogenesis of many canine tumours are likely to be similar to cancers found in humans. This study aimed to evaluate a plausible link between changes in the tRNA-Leu (UUR) gene and the carcinogenesis process in dogs with mammary gland tumours. The whole mitochondrial DNA (mtDNA) isolated from blood and tumour tissues of 13 dogs with malignant mammary gland tumours was sequenced. The present work is the first report showing that some polymorphisms might occur at the corresponding positions in the human and canine mtDNA genome, which in turn may provoke similar deleterious effects. The homology between the human MT-TL1 and canine tRNA-Leu (UUR) genes was 84%. After resequencing of the whole mitochondrial DNA genome with the use of the NGS technology, two polymorphisms in two haplotypes were identified: m.2683G>A (observed in 18 out of 27 samples) and m.2678_2679insG (27 out of 27 samples). The m.2683G>A polymorphism corresponded to a deleterious change at m.3243A>G, which is linked with MELAS (Mitochondrial Encephalomyopathy, Lactic Acidosis, Stroke-like episodes) syndrome and with different types of cancers in humans as well. The comparative analysis of MT-TL1 and tRNA-Leu (UUR) led us to hypothesise that the m.2678_2679insG and m.2683G>A polymorphisms might influence the dog’s condition and might be linked with tumourigenesis, as observed in humans.
Analysis of modern wood processing techniques in timber terminals
Authors: Kunickaya Oľga , Pomiguev Aleksandr , Kruchinin Igor , Storodubtseva Tamara , Voronova Anna , Levushkin Dmitry , Borisov Vyacheslav , Ivanov Viktor 
Published: March 2022

Abstract
The transportation of forestry products is performed over long distances and is quite expensive, which limits the development of biofuel plants in Russia and around the world. The use of timber terminals contributes to transportation cost reduction and mitigates negative environmental impacts. This work aims to analyze various technological solutions for optimization of forestry products processing at temporary terminals and cost reduction of transportation, shipping, and wood treatment. The work presents a discussion on the technological and economic possibilities of the mobile pellet plant, the mobile essential oil production plant, and an enhanced autonomous electric generator system. It is shown that the use of mobile plants for obtaining pellets and essential oils allows processing wood residues at the terminal, which reduces the cost of transportation and shipment of raw materials and improves the quality of the finished products. The current study also examines some of the modern scanning technologies used to detect log defects and obtain complete biometric information in real time while assessing the productivity of wood processing operations. The results of the study can be used to develop efficient movable timber terminals.
Impact of interest rates on forest management planning based on multi-criteria decision analysis
Authors: Merganič Ján , Merganičová Katarína , Výbošťok Jozef , Valent Peter , Bahýľ Ján 
Published: March 2022

Abstract
The fulfilment of forest functions is significantly affected by forest management, especially the applied harvest regeneration systems. The interest rate can significantly influence forest regeneration planning but was rarely tested. We examined how different interest rates (0%, 0.5%, 1%, 1.5%, 2%, 2.5% and 3%) affect the fulfilment of multiple forest functions and hence, the decision on the optimal forest regeneration system for multiple criteria. The analysis was performed based on the simulation of 450 different harvest-regeneration systems applied to a secondary spruce dominated forest stand and the multi-criteria a posteriori decision analysis. The outputs from the growth simulator were used to quantify the fulfilment of timber production and non-production functions. Three selected indicators (Soil expectation value, Shannon index of species diversity, and height to diameter ratio) were analysed on the base of single-criteria optimisation based on maximising a single indicator and the methods of multi-criteria optimisation of the weighted sum method and Pareto front with the goal to harmonise the fulfilment of three different functions. The results indicated that lower interest rates favoured single tree cutting systems with relatively long rotation cycles (140–160 years), while higher interest rates favoured strip cutting with shorter rotation cycles (90–100 years).
Influence of water supply on cork increment and quality in Quercus suber L.
Authors: Poeiras Ana Patrícia , Oliveira Teresa , Reis Joana , Surový Peter , Silva Maria Emília , de Almeida Ribeiro Nuno 
Published: March 2022

Abstract
Cork oak (Quercus suber L.) grows in the Mediterranean basis including Portugal and is the main species producing cork which is used prevailingly in stopper industry. In our paper, cork from Quercus suber L. over three consecutive harvests from a traditional rainfed plot, between 1999 and 2017, and cork from an irrigated plot, harvested in 2017, were studied. We applied two X–ray image analysis technologies – X–ray micro-computed tomography and X–ray microdensitometry. Cork development, related with intern porosity, growth and density was studied with the objective of understanding the cork characteristics evolution over the years and with a different water regime. The outcomes of this study suggested an increase in density and porosity over harvests and a slight decrease of the cork growth. Cork samples from the irrigated plot, compared with cork from the same year of extraction in the rainfed plot, showed higher growth rate and higher porosity. The results demonstrated the contribution of climatic factor of precipitation as well as the silviculture model in cork characteristics, showing the relevance of the present work for the definition of the management practices. These may be determinant for enhancing cork quality and quantity production through silviculture measures. Our findings can be particularly useful for stakeholders especially under the conditions of Portugal in terms of increasing the value of the industrial chain of cork.
Anno, M. (2021). "Los viajes. Europa". Traductor: Gabriel Álvarez Martínez, Kalandraka. 64pp.
Authors: Escrig Aparicio José Antonio 
Published: March 2022

MITSUMASA ANNO: JUEGO E IDILIO
Reseña de José Antonio Escrig Aparicio, Anno, M. (2021). "Los viajes. Europa". Traductor: Gabriel Álvarez Martínez, Kalandraka. 64pp
Oversampling Approach Using Radius-SMOTE for Imbalance Electroencephalography Datasets
Authors: Wardoyo Retantyo , Wirawan I Made Agus , Pradipta I Gede Angga 
Published: March 2022

Several studies related to emotion recognition based on Electroencephalogram signals have been carried out in feature extraction, feature representation, and classification. However, emotion recognition is strongly influenced by the distribution or balance of Electroencephalogram data. On the other hand, the limited data obtained significantly affects the imbalance condition of the resulting Electroencephalogram signal data. It has an impact on the low accuracy of emotion recognition. Therefore, based on these problems, the contribution of this research is to propose the Radius SMOTE method to overcome the imbalance of the DEAP dataset in the emotion recognition process. In addition to the EEG data oversampling process, there are several vital processes in emotion recognition based on EEG signals, including the feature extraction process and the emotion classification process. This study uses the Differential Entropy (DE) method in the EEG feature extraction process. The classification process in this study compares two classification methods, namely the Decision Tree method and the Convolutional Neural Network method. Based on the classification process using the Decision Tree method, the application of oversampling with the Radius SMOTE method resulted in the accuracy of recognizing arousal and valence emotions of 78.78% and 75.14%, respectively. Meanwhile, the Convolutional Neural Network method can accurately identify the arousal and valence emotions of 82.10% and 78.99%, respectively. Doi: 10.28991/ESJ-2022-06-02-013 Full Text: PDF
The Effect of 5E-Learning Cycle Model Using Animation Media on the Learning Activity and Learning Outcomes of Students in Senior High School Class XI on Salt Hydrolysis Material
Authors: Iqbal M , Mawardi Mawardi 
Published: March 2022

The aim of this study is to determine the effect of learning model 5E learning cycle on learning activities and student learning outcomes on salt hydrolysis material. The research was conducted at Senior High School (SMA) Negeri 10 Medan. This research used research design of Pretest-posttest control group design. The sample was taken by purposive sampling technique and the obtained sample consist of 2 class which is: XI IPA 2 as an experimental class and XI IPA I as a control class. In the experimental class was taught used learning model 5E learning cycle using animation media and in control, class was taught using direct instruction model using animation media. The research instrument used the objective test in form of multiple choice questions as many as 25 questions, which previously passed through validation test, difficulty test, the test of different power, and reliability test with reliability value 0,91. Data analysis in this study used parametric inferential statistical analysis method, which the pretest and normalized score data had to pass normality and homogeneity test. X2count the pretest and gain score in the two study classes is greater than X2table and F-count the pretest and gain score in both the research class is greater than F-table. The research hypothesis was tested using statistical right-tailed t-test. Based on the calculation of t-statistical using right-tailed t-test obtained t-count results 4.29 and t-table at the 0.05 significance level 1.99. Furthermore, by t-count> t-table implied that the results of this study indicate there is influence of learning model of learning cycle 5E using animation media to the student learning outcomes in SMA of class XI on salt hydrolysis and student learning activity taught by learning model 5E learning cycle using animation media equal to 64,88%, higher than the student learning activity taught by direct instruction model using animation media that is equal to 55,72%.
Using Pixton to Improve Students’ Creativity on Creating Dialogue
Authors: Nurhaliza Nisrina , Khairunnisa Rana 
Published: March 2022

Pixton is an interesting comic creation site that can for the teacher and the students on creating dialogue during the teaching and learning process. This research was aimed at revealing the use of Pixton to improve students’ creativity on creating dialogue. This is a descriptive study in which the data from the field was analyzed descriptively. One teacher and three students participated in this research. To investigate the use of Pixton whether it affected the positive roles or not, observation and interview were used. The observation showed that the teacher gave the procedure in using Pixton clearly and the students understand it easily. On the other hand, the interview provided a result that a teacher and a student some ideas about Pixton such as can improve the creativity, easy to access, enjoyable application, etc. Furthermore, there are some, using Pixton also as a way to create a dialogue efficiently and effectively.
KAJIAN KERENTANAN SOSIAL TERHADAP BENCANA BANJIR
Authors: Puspitotanti Endah , Karmilah Milla 
Published: March 2022

ABSTRACTFlood is a natural phenomenon that occurs due to high rainfall intensity which causes excess water that is not accommodated by the drainage network of an area (Rachmat & Pamungkas, 2014). Based on the 2015 BNPB disaster risk assessment in (BNPB, 2016), the number of people exposed to flood risk in all regions of Indonesia is more than 170 million people with an exposed asset value of more than IDR 750 trillion. Floods are disasters that always occur every year in several places. The composition of the population greatly affects the level of social vulnerability to floods. Therefore, this research needs to be carried out with the aim of identifying social vulnerability to flood disasters as one of the disaster management efforts to reduce disaster risk.The method used in this research is qualitative method with a literature review approach. The results showed that the level of social vulnerability in Baleendah District, East Tondano District, and the coastal villages of Demak Regency is influenced by several factors. These factors are population, population according to sex, population according to age group, population density, poverty level, population with disabilities, level of dependency, number of family members, population growth, education level, and health insurance.Keywords: Social Vulnerability, Flood Disaster, Vulnerability Factors ABSTRAKBanjir adalah fenomena alam yang terjadi akibat intensitas curah hujan yang tinggi yang menyebabkan kelebihan air yang tidak tertampung oleh jaringan pematusan suatu wilayah (Rachmat & Pamungkas, 2014). Berdasarkan kajian risiko bencana BNPB tahun 2015 dalam (BNPB, 2016), jumlah jiwa terpapar risiko bencana banjir di seluruh wilayah Indonesia yaitu lebih dari 170 juta jiwa dengan nilai aset terpaparnya lebih dari Rp750 triliun. Banjir merupakan bencana yang selalu terjadi setiap tahun di beberapa tempat. Komposisi penduduk sangat mempengaruhi tingkat kerentanan sosial terhadap bencana banjir. Oleh karena itu, penelitian ini perlu dilakukan dengan tujuan untuk mengidentifikasi kerentanan sosial terhadap bencana banjir sebagai salah satu upaya penanggulangan bencana untuk mengurangi risiko bencana.Metode yang digunakan dalam penelitian ini yaitu metode kualitatif dengan pendekatan kajian literatur. Hasil penelitian menunjukkan bahwa tingkat kerentanan sosial di Kecamatan Baleendah, Kecamatan Tondano Timur, dan pedesaan pesisir Kabupaten Demak dipengaruhi oleh beberapa faktor. Faktor-faktor tersebut yaitu jumlah penduduk, penduduk menurut jenis kelamin, penduduk menurut kelompok umur, kepadatan penduduk, tingkat kemiskinan, penduduk penyandang disabilitas, tingkat ketergantungan, jumlah anggota keluarga, pertumbuhan penduduk, tingkat pendidikan, dan jaminan kesehatan.Kata kunci: Kerentanan Sosial, Bencana Banjir, Faktor Kerentanan
Comparison of in vitro, in vivo, and in silico bioavailability results of different prednisone tablet formulations to assess the feasibility of possible biowaiver
Authors: Toehwé Leonardo Henrique , Da Silva Honorio Thiago , Rodrigues Pereira da Silva Luiz Claudio , Da Silva Thalita Martins , Da Rocha Pitta Luciana , Deris Prado Livia , Mendes Cabral Lucio , Antunes Rocha Helvécio Vinícius 
Published: March 2022

Introduction: The immediate-release solid oral products containing very soluble and permeable drugs are candidates for the biowaiver process. This work aims to compare in vitro, in silico, and in vivo data to establish if previously published prednisone oral tablet formulations are biowaiver candidates.
Method: To achieve this goal, permeation studies were conducted on Caco-2 cells. A previous bioequivalence study between the test and the reference drug product was applied on an in silico evaluation using Gastroplus® to assess the bioequivalence of two other previously proposed formulations.
Results: The apparent permeability coefficient for prednisone presented a value of 3.69 x 10-5 cm/s in 180 minutes. The bioequivalence study shows that the tested and reference product was equivalent. The in silico simulations successfully predicted the pharmacokinetics of the tested and the other two formulations since they were validated with the in vivo study. Both exhibit the same plasma concentration vs. time profiles.
Conclusions: Through the in silico results, it is possible to infer that the other two formulations tested may be bioequivalent concerning the reference product. This result may be helpful in biowaiver requesting. Toward to reduce costs and the use of human beings in bioequivalence studies, this approach could be an essential way to work in the pharmaceutical industry.
La farmacéutica Milagro Almenara Pérez, del olvido a su reconocimiento
Authors: Núñez Valdés Juan , Ramos Carrillo Antonio 
Published: March 2022

Introducción: Milagro Almenara Pérez se licenció en la Facultad de Farmacia de la Universidad de Granada en 1921. Sin embargo, tras la Guerra Civil, parece que ella nunca existió, y no solo su persona, sino también su expediente universitario e incluso la farmacia de Granada en la que trabajó. En este artículo se muestra una breve biografía suya, con el doble objetivo de ponerla como referente ante la sociedad y también de ilustrar las muchas similitudes existentes entre su vida y la del conocido poeta granadino Federico García Lorca.
Método: Búsqueda de información sobre Milagro Almenara Pérez en fuentes archivísticas, bibliográficas, digitales e incluso periodísticas, que ha permitido completar con datos nuevos y recientes algunos aspectos biográficos que no se encuentran en los no muy abundantes trabajos de investigación ya publicados sobre ella.
Resultados: Como resultado del estudio realizado se han añadido datos originales recientes a la biografía de Milagro Almenara Pérez y se justifica la hipótesis de la existencia de una determinada similitud entre su vida y la del poeta andaluz Federico García Lorca.
Conclusiones: Durante la Guerra Civil Española se destruyeron, por parte de ambos bandos, muchos documentos, tanto personales como institucionales, que atañían a aquellas personas a las que cada bando consideraba desafectas. Entre ellas, la farmacéutica Milagro Almenara, cuya vida presenta muchas coincidencias con la del poeta Federico García Lorca.
THE ROLE OF MARKETING MIX STRATEGIES IN CONSUMER CONVENIENCE OF RURAL BANKS IN NORTH SUMATERA
Authors: Sihombing Nikous Soter , Sitorus Sunday Ade 
Published: March 2022

<p>Rural Banks has the opportunity to increase third party fund in the form of saving and pension credit distribution. Both purposes can be achieved by increasing pensioner customers who make Rural Banks the paymaster of their pension fund. If this problem did not meet the solution or the right handling, it might increase the stagnant customers so that Rural Banks would lose the opportunity to increase third party fund and profit from loan distributed. The purpose of this study was to find out the marketing mix factor that most influence to the customer convenience at the Rural Banks . This is intended to help formulate a marketing strategy to attract customer to become product customer and increase Rural Banks, saving and credit volume. In this study, the method used was survey approach. The type of this study was quantitative descriptive and the nature of this study was descriptive explanatory. Data collection method was carried out using questionnaire and documentation. The data analysis used was multiple regression. Simultaneously, the result showed that the price variable had no effect on the customer convenience to become a customer at the Rural Banks, but the location variable had a strong influence on the decision to become a product customer at the Rural Banks. Product, location, promotion, price, person, and process variables simultaneously had a positive and significant effect on the increase the number of retirees at Rural Banks. This showed that with product offered according to need, location that was easy to reach, attractive promotion, employees who were friendly and working well, a fast process and affordable credit interest rates could boost the positive impact on increasing the number of customers at the Rural Banks, .</p>
Preparation and Characterization of Biodegradable Microspheres Containing Sertraline Hydrochloride
Authors: H. Samein Laith , A. Hussein Ahmed , A. Abdulrasool Alaa , A. Faraj Jabar 
Published: March 2022

Four batches of sertraline HCl microspheres were prepared using a poly (D-L-lactide-co-glycolide) (PLGA) polymer ( Mw. 9, 27, 30 and 83 KDa) as a delivery system. The microspheres were prepared by a dispersion/solvent extraction-evaporation method and characterized for drug loading by UV, particle size by laser diffractometry and surface morphology by scanning electron microscopy (SEM). The in vitro sertraline HCl release was studied. Spherical microspheres with a mean diameter of 21 to 26 Âµm loaded with 24.6 â€“ 38.2% were produced. The in vitro drug release was shown to be depend on polymer molecular weight and also on the drug loading. Differential scanning calorimetry (DSC) was employed to investigate the physical state of sertraline HCl inside the microspheres and stability and polymer interaction study were performed in solution.
Key words: Sertraline HCl , Microspheres , PLGA polymer