bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extended infusion of cephalosporins, penicillins and carbapenems: a cost-effective point-of-view and critical appraisal of Surviving Sepsis Campaign guidelines
Authors: Decker Sérgio Renato da Rosa , Marzzani Lucas Emanuel , Ferreira Pedro Rotta de 
Published: November 2022

Narrative/ introduction. In the last edition of the Surviving Sepsis Campaign guidelines - SSC guidelines - recommendations regarding the optimization of antibiotics pharmacokinetics and pharmacodynamics (PK/PD) were made. Among these, the use of extended infusion of beta-lactams (penicillins, cephalosporins and carbapenems), are proposed to improve clinical and microbiological outcomes. However, according to the authors, studies of the economic implications of extended infusion – cost-effectiveness studies – are needed for these recommendations.
Caveats. Sepsis represents a huge economic burden around the world due to the need for hospital and ICU beds, qualified staff and therapies for the treatment of the pathology, whereas it is known that antibiotics are the mainstay therapy. The basic research question for cost-effectiveness studies is to understand the superiority of a new and more expensive intervention over the "standard" therapy and, then, the implications of this in a health system and time perspective. However, extended infusion of antibiotics has shown a benefit in clinical outcomes and its use can reduce direct costs since is less expensive than the standard approach, considering that smaller amounts of the antibiotic are needed to reach the same PK/PD and clinical effect. Moreover, additional costs to do an extended infusion would not be significant, and more effective therapy could also reduce the indirect economic burden on the health systems. Therefore, it is beyond the scope of cost-effectiveness analyses, and should be incorporated by health systems.
Alelopathic activity of extracts of Ocotea puberula (Rich.) Nees on the germination and initial growth of lettuce
Authors: Bonini Edicléia Aparecida , Jungbluth Daiana , Ascari Jociani 
Published: November 2022

The interest in the exploration of compounds from the secondary metabolism is seen as a strategic alternative in agriculture, even for the control of invasive plants. The objective of this work was to measure the allelopathic activity of extracts CHCl3 and AcOEt from the leaves of O. puberula on the germination of lettuce. The ethanolic extract was obtained from the dried and milled leaves. The crude extract was solubilized in ethanol and acidified (hydroalcoholic fraction). The C6H14 fraction was obtained by liquid-liquid extraction of the hydroalcoholic fraction, the same procedure was used to extract the AcOEt fraction. The hydroalcoholic fraction was basified and extracted with CHCl3. The chemical profile of the obtained fractions was analyzed by Thin Layer Chromatography using specific revelators that confirmed the presence of alkaloids as majority compounds in AcOEt and CHCl3 fractions. The fractions were evaluated for allelopathic potential on lettuce cypselas at 0.8 g mL‑1, 0.4 g mL-1 and 0.2 g mL-1. In germination tests the germination parameters analyzed were: germination percentage (% G) and germination speed index (IVG). The results indicated significant changes in the %G, IVG and root growth (CR) of the lettuce seeds and seedlings. The ethanolic extract of leaves of O. puberula showed allelopathic influence on the species L. sativa. Both the AcOEt and CHCl3 fractions reduced the germination rates evaluated, and the latter indicated a dose-response inhibition between the treatments applied.
Nederlandbeelden in Oorlog met het kleine Nederland (1965). Een nooit opgevoerde twee-akter van Rudolf Sloboda
Authors: Bossaert Benjamin 
Published: November 2022

De Slowaakse schrijver Rudolf Sloboda geldt als een van de meest vooraanstaande auteurs van Slowaakse literatuur na de Tweede Wereldoorlog. Zijn oeuvre valt uiteen in proza dat volgens Sloboda-kenner Zora Prušková uiterst autobiografisch te noemen valt, maar hij schreef naast enkele gedichtenbundels, essays en kinderboeken ook diverse filmscenario´s en twee toneelstukken. De meeste biografen vergeten daarbij dikwijls nog een twee-akter te vermelden die in 1965 in twee nummers van het literaire tijdschrift Slovenské pohľady kon verschijnen als Vojna s malým Holandskom (Oorlog met het kleine Nederland), omdat dit toneelstuk nooit werd opgevoerd.
In deze bijdrage worden enkele opvallende kenmerken van het stuk uiteengezet. Daarbij wordt de ontstaanscontext van het stuk geschetst, die gepaard ging met de censuur van het communistische regime. Er wordt uiteindelijk betoogd dat, als de geografische benamingen en de personages goed onder de loep genomen worden, hier een imagologische en chronotopische tegenvoeter gecreëerd werd van het absurde toneelstuk Ubu roi van Alfred Jarry, met Nederland als een abstract genoeg begrip.
Boventitelen als vorm van audiovisueel vertalen en de receptie ervan in moderne operavoorstellingen in Nederland
Authors: Van der Horst Pim 
Published: November 2022

Boventitels zijn bijna niet meer weg te denken uit hedendaagse operavoorstellingen. Dankzij boventitels worden opera’s die in een vreemde taal worden opgevoerd toegankelijker voor een breder publiek en krijgen operagezelschappen meer keuze bij het samenstellen van hun repertoire. Dankzij de nauwe band met de opvoering van een opera wijkt boventitelen enigszins af van andere vormen van audiovisueel vertalen zoals ondertitelen. Bovendien zijn er bij boventitelen in het vertaalproces andere spelers die een stempel op de vertaling drukken, zoals regisseurs en dirigenten. In het eerste deel van dit artikel wordt boventitelen nader uitgelegd en in de bredere context van het audiovisueel vertalen geplaatst.
De introductie van boventiteling is echter niet zonder slag of stoot gegaan. Vooral in de operawereld was er sprake van weerstand tegen boventitels. In het tweede deel van dit artikel zal nader worden ingegaan op de redenen voor deze weerstand en zal aan de hand van recente recensies van operavoorstellingen worden getracht vast te stellen hoe er in Nederland op dit moment wordt aangekeken tegen boventitels in de opera.
La vida de Higinio de la Luz en Murcia (sureste de España): Una posible imitación de modelos hagiográficos tardo-romanos
Authors: Molina Gómez José Antonio 
Published: November 2022

El erudito decimonónico Javier Fuentes y Ponte afirmó haber leído en un manuscrito ahora desparecido la historia de un anacoreta llamado Higinio, que era discípulo de San Ginés, y que llegó desde el monasterio de su maestro situado en San Ginés de la Jara (Campo de Cartagena, en pie hasta tiempos modernos, actualmente en ruinas y a la espera de la protección oficial) hasta el sur de Murcia en el siglo IX y fundó allí los eremitorios y monasterios rupestres existentes de las montañas de la Luz. Esta información fue considerada como una falsificación por el propio Fuentes y muy dudosa por los historiadores posteriores. Pero si el manuscrito fue escrito en tiempos modernos todavía permanece sin resolver por qué el anónimo escritor sabía que existía en la población cercana La Alberca una capilla romana emplazada en un cementerio donde se supone que Higinio acudía a crear y cuya existencia era completamente desconocida por los arqueólogos hasta época reciente (el llamado “martyrium de La Alberca”).
Además de que la historia de Higinio, tal y como la conocemos parcialmente a través del resumen que de ella hace Fuentes y Ponte, comparte muchos tópicos literarios que forman parte de las hagiografías tradicionales, nuestra hipótesis es que la vida perdida de Higinio fue escrita originariamente en el entorno del monasterio de San Ginés y formaba parte de algunas informaciones tardía sobre San Ginés y sus discípulos que todavía existían para uso de los peregrinos que acudían y que todavía existían en el siglo XVI.
Stance Expressions in Introduction of English Research Articles written by Cambodian Authors
Authors: Chenda Soeurn , Safnil Safnil , Syafryadin Syafryadin 
Published: November 2022

Stance Expression indicates feelings, certainty or uncertainty, and interests of the authors. As the increasing needs of the readers on significant findings from the introduction section of Research Articles, a study on Stance Expression of introduction section in the English research articles written by Cambodian authors has been conducted to employ crucial aims of the study: (1) examine stance expression types and the categories of each type; (2) compare the similarities and differences of stance expression types used in the introduction section of English RAs written by Cambodian authors published in local and international journals. Thirty research articles written by Cambodian authors published in local and international journals were used in this study. To fulfill these research objectives, the mixed-method research design was utilized in this study. All the four stance features, such as Hedges, Boosters, Attitude Markers, and Self-expression, proposed by Hyland (2005) were used as a Lexical analysis framework model in this study. The results revealed that four stance expression types were found in this study. The hedge was the most frequently employed among the other types of stances. There is a significantly different in terms of the frequencies of hedge used within both RA journals, but there is no for booster, attitude marker, and self-mention. Local Cambodian authors should follow the international authors as models in applying stance in their RAs. A comparison study of the stance expression and engagement between Cambodian and international authors in the introduction should be expanded more different articles from available journals.Keywords: English research article, introduction section, stance expression, local journals, international journals
ACESSIBILIDADE NO ENSINO MUSICAL DE PESSOAS COM TRANSTORNO DO ESPECTRO DO AUTISMO ATRAVÉS DE RECURSOS DE TECNOLOGIA ASSISTIVA
Authors: Cunha Roger Vieira , Asnis Valéria Peres , Mendes Adriana Do Nascimento Araújo 
Published: November 2022

Este artigo apresenta um estudo sobre o processo de ensino-aprendizagem na educação musical de pessoas com Transtorno do Espectro do Autismo (TEA) tendo como auxílio a utilização de Tecnologia Assistiva (TA). O objetivo geral desta pesquisa foi estudar como a Educação Musical, com auxílio de recursos de Tecnologia Assistiva, pode contribuir para o desenvolvimento de pessoas com o TEA. Seus objetivos específicos são: a) investigar como se dá o ensino-aprendizagem musical dos estudantes com TEA; b) elencar, através de levantamento bibliográfico, atividades musicais adaptadas para pessoas com TEA e c) indicar de que forma os recursos de TA podem auxiliar na acessibilidade dessas atividades. A partir de uma pesquisa bibliográfica de autoras e autores estudados como LOURO (2018; 2021), ASNIS e ELIAS (2019), HAMMEL e HOURIGAN (2020) e SOARES (2020), que se debruçam em estudos e pesquisas acerca dos processos de ensino-aprendizagem musical de pessoas com deficiência - com destaque nas especificidades para pessoas com o TEA, chegou-se a uma lista de atividades adaptadas para esse público. Através da combinação das palavras-chave Tecnologia Assistiva e Educação Musical e de práticas pedagógicas já realizadas pelos autores, selecionamos dois recursos de TA utilizados em processos de ensino-aprendizagem musicais: os softwares GenVirtual e o AUMI, e um terceiro recurso que possui grande potencial para ser utilizado com estudantes com TEA: a plataforma Chrome Music Lab. Ao final, elencamos esses recursos de Tecnologia Assistiva com as atividades, discutindo e propondo uma prática pedagógica que pode gerar, assim, acessibilidade e autonomia de estudantes com TEA.
Estresse e burnout em enfermeiros da emergência de um hospital referência em urgência e trauma
Authors: Ferreira Maria Clara Leandro , Silva Silmar Maria , Souza Sandra 
Published: November 2022

Objetivo: investigar o estresse e Burnout nos enfermeiros da emergência de um pronto-socorro referência em trauma em Belo Horizonte. Método: estudo transversal, descritivo, quantitativo, com 46 enfermeiros da emergência, realizado a partir da Job Stress Scale, do Maslach Burnout Inventory e de uma ficha de dados sociodemográficos. Resultados: 65,22% dos enfermeiros possuíam alta demanda psicológica. No Modelo Demanda-Controle, 34,78% dos enfermeiros estavam trabalhando ativamente e 30,43% em alto desgaste, ocasionando efeitos nocivos à saúde. Quanto ao Burnout, 23,91% apresentaram alto desgaste emocional, 21,74% alta despersonalização e 28,26% baixa realização profissional, sendo que três enfermeiras já estavam em Burnout. Conclusão: existe correlação entre estresse e Burnout. Os enfermeiros estão expostos a um ambiente laboral altamente estressante, propício ao desenvolvimento de Burnout. É preciso implementar estratégias objetivando o enfrentamento do estresse e a prevenção de Burnout, além de tratar os já adoecidos.
Implicações do cuidado informal à saúde de pessoas dependentes assistidas no domicílio pós-alta hospitalar
Authors: Rodrigues Thamires Fernandes Cardoso da Silva , Dos Santos Fernanda Gatez Trevisan , Silva Eraldo Shunck , Bernardino Elizabeth , Salci Maria Aparecida , Radovanovic Cremilde Aparecida Trindade 
Published: November 2022

Objetivo: identificar as implicações do cuidado informal à saúde de pessoas dependentes assistidas no domicílio após a alta hospitalar. Método: estudo transversal realizado com 41 díades cuidadores informais-pessoas dependentes que receberam alta para o domicílio. Coletaram-se os dados por meio de questionários. Realizou-se Regressão Logística Binomial. Resultados: deixar as atividades laborais eleva em 55,79 as chances de cuidar de pessoa com lesão por pressão. O uso de medicamentos contínuos associou-se ao desenvolvimento de lesões por pressão (OR=37,80), eventos adversos (OR=40,39) e óbito (OR=54,68). O tempo em horas dedicado ao cuidado reduz a chance de lesão por pressão (OR=0,81), a idade do cuidador diminui os eventos adversos (OR=0,91) e o óbito após a desospitalização (OR=0,91). Conclusão: as implicações foram as lesões por pressão, eventos adversos e o falecimento da pessoa dependente após a alta hospitalar, as quais se associaram à necessidade de deixar o emprego e ao uso de medicações contínuas.
Caracterização dos incidentes notificados envolvendo o uso de medicamentos em unidades de internação adulto
Authors: Terra Igor , De Oliveira Riboldi Caren , Silveira Pasin Simone , Terezinha Rotta Eloni , Muller de Magalhães Ana Maria , Wegner Wiliam 
Published: November 2022

Objetivo: caracterizar os incidentes notificados envolvendo o uso de medicamentos em unidades de internação adulto de um hospital universitário. Método: estudo observacional do tipo transversal, em um hospital universitário de grande porte no sul do país. Utilizaram-se 1896 notificações do sistema eletrônico da instituição referente aos erros de medicação, entre 2015 e 2017, em 13 unidades de internação adulto clínica e cirúrgica. Para análise das variáveis utilizou-se um instrumento próprio e estatística descritiva. Resultados: os incidentes de medicação estiveram relacionados à prescrição (85,9%) e administração (10,1%) e envolviam o atraso da prescrição (77%) e a dose errada (7,9%), respectivamente. Os erros concentraram-se no ano de 2015 (70,2%), em unidades de internação cirúrgica (90%) e verificou-se informações preenchidas parcialmente e/ou incompletas nas notificações (70%). Conclusão: a caracterização dos incidentes subsidiou a implementação de estratégias pelos gestores da instituição, voltadas para a problemática, reduzindo as ocorrências e melhorando o cuidado ao paciente.
ANALISIS PERBANDINGAN PRODUKSI BIOGAS CAMPURAN KOTORAN AYAM DAN KOTORAN SAPI DENGAN STARTER RUMEN SAPI
Authors: Suanggana Doddy , Manta Faisal , Hanifudin Reza Naufal 
Published: November 2022

Biogas is a combustible gas produced by anaerobic activity or the fermentation of organic matter by microorganisms. This study produces biogas made from chicken manure and cow manure with a ratio of mass composition D1 (25%: 75%), mass composition D2 (50%: 50%), and mass composition D3 (75%: 25%) with a combined mixture that is 75% of the digester capacity and the addition of beef rumen by 1 kg in all variations as a starter. The purpose of this study was to examine the effect of composition on pressure, mass, temperature, and flame quality of the biogas production of chicken manure and cow manure with a mixture of cow rumen. Data were collected every 06.00 WITA and 18.00 WITA and temperature measurements were every 6 hours for 20 consecutive days. The results showed that the temperature at 18.00 WITA was better than at 06.00 WITA with the highest temperature occurring in the D2 variation of 29.85oC. The results of the measurement of biogas mass and pressure showed that the highest value was in the D3 variation at 18.00 WITA on the day to -9 with values ​​of 68.32 grams and 0.054 bar, respectively, with the total mass and pressure of biogas in the D3 variation of 401.14 grams and 0.391 bar.

Keywords: Biogas, Chicken Manure, Cow Manure, and Cow Rumen.
Evaluación de Políticas de Integridad Pública y Anticorrupción: Los Desafíos de una Iniciativa Nacional para Gobiernos Locales en Brasil
Authors: De Bona Rodrigo da Silva 
Published: November 2022

Objetivo: Investigar como se puede evaluar cualitativamente la eficacia de políticas de integridad y anticorrupción en gobiernos locales, analizando un programa federal implementado experimentalmente, entre el 2018 y el 2020, en una muestra de 12 de entre 25 municipios brasileños voluntarios.
Encuadramiento teórico: Análisis de la política y evaluación basada en un modelo de gestión de integridad organizacional publicado por la OCDE.
Metodología: Investigación evaluativa y exploratoria con procedimientos de observación participante, análisis de contenido y estadística descriptiva.
Resultados: Fueron evidenciados 26 tipologías de productos, 15 clases de instrumentos, 17 procesos y 16 estructuras (actores) centrales del programa. La eficacia cuantitativa del periodo fue de solamente un 65 %, pero la política es sujeta a gaps de implementación que pueden impactar su eficacia, y principalmente su eficiencia y efectividad. El Time carece de un modelo de cambio definido (theory of change), con objetivos mensurables e indicadores de desempeño. Cualitativamente, cuanto a la coherencia del modelo y balanceo de las medidas, muchas dependen de interacción con el contexto externo y son del tipo rule-based. A pesar de sus límites, la política es innovadora y puede tener rol fundamental para el desarrollo de capacidades institucionales en gobiernos locales brasileños, que tienen elevada ocurrencia de corrupción y sistemas de integridad muy frágiles.
Originalidad: Casi no existen trabajos teórico-empíricos sobre políticas de integridad en gobiernos locales de Brasil.
Contribuciones teóricas y prácticas: La política está en desarrollo y se puede ajustarla, incluyendo énfasis a la creación de una agenda local e inclusión de medidas value-based. Como contribución teórica, fueron añadidos nuevos elementos al modelo utilizado.
A New Modeling Method for the Sandbody Architecture of Braided River Reservoirs: A Case Study from HG Formation, N Gas Field
Authors: Jiang Lei , Li Shaohua , Duan Dongping , Ding Fang , Yu Siyu 
Published: November 2022

Abstract
A new modeling method is proposed to address the shortcomings of conventional geological modeling methods in simultaneously characterizing the geometry, stacking patterns, and well data of the channel bar in braided river. The channel bar model is reconstructed based on the target body, which is defined by the channel bar’s geometric parameters points, lines, and surfaces. In the simulation process, the distributions of sandstone and mudstone are simulated first. Then, the channel bars at the well are simulated based on the channel bars identified on the well and the thickness of the sandstone, the priori geometries, and sizes of the channel bars. It is judged whether the proportion of the simulated channel bars has reached the global proportion. If not, a randomly selected point between wells is used as a virtual well, and the sandstone thickness is used to determine whether it is a single or composite channel bar. The process is repeated until the proportion of channel bars reaches the set proportion. Take the N gas field as an example. The analysis of the geometry, variance function, thickness distribution histogram, and volume distribution histogram of the simulation results shows that the new method can better characterize the channel bar’s geometry, sizes, and stacking patterns than the multipoint geostatistical modeling method Snesim.
Spatial embryo profiling (STEP) of primate implantation stages
Authors: Sophie Bergmann , Christopher Penfold , Erin Slatery , Thorsten Boroviak 
Published: November 2022

Abstract
Spatial embryo profiling (STEP) combines laser capture microdissection (LCM)-assisted sample collection for Smart-Seq2 profiling with virtual reconstruction of stereological immunofluorescence images of implanted primate embryos. Frozen, unfixed embryos O.C.T.-embedded in utero are cryosectioned, with every second to third embryo-containing section subjected to LCM for collection of tissue samples of one-to-three cells and processed individually for full-length transcriptome profiling. Remaining sections are fixed and processed for immunofluorescence staining, followed by stereological confocal microscopy, image registration, tissue segmentation and surface generation to create virtual 3D embryo models. Gaussian process regression following the integration of discrete, spatially defined transcriptome samples allows modelling of 3D gene expression patterns across the entire embryo model.
Gastric Pneumatosis in a Preterm Infant: a Case Report and Review of Literature
Authors: Bonitatibus Giacomo , Paterlini Giuseppe Luigi , Zanzucchi Matteo , Perotti Valentina , Villani Paolo Ernesto 
Published: November 2022

Abstract
Background: gastric pneumatosis is a rare sign with a primarily radiological diagnosis. In newborn infants, this finding should raise the suspicion of necrotizing enterocolitis, which represents a serious clinical condition with high morbidity and mortality. However, other causes of gastric pneumatosis are reported in literature, including intramural displacement of a feeding tube. In this report we present a case of gastric pneumatosis in a preterm boy admitted to our NICU.
Case presentation: the baby appeared pale and poor responsive during the first days of life on positive pressure ventilation and gavage feeding. A distended upper abdomen with bloody and biliary gastric aspirates was noted; no bloody stools were reported. Blood cultures, cerebrospinal fluid culture and blood cell count were normal; acute phase proteins were negative on serial determinations. Abdominal X-Ray showed gastric pneumatosis with displacement of the feeding tube and no other pathological findings in the rest of the bowel. After few days of conservative management, the baby improved dramatically.
Conclusions: we suggest that the cause of this clinical picture could have been a mechanical lesion in gastric mucosa caused by the feeding tube; positive pressure ventilation then could have raised intragastric pressure, leading air to diffuse between the layers of the gastric wall.