bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis, consultation, treatment, and impact of migraine in the US: Results of the OVERCOME (US) study
Authors: Lipton Richard B. , Nicholson Robert A. , Reed Michael L. , Araujo Andre B. , Jaffe Dena H. , Faries Douglas E. , Buse Dawn C. , Shapiro Robert E. , Ashina Sait , Cambron‐Mellott M. Janelle , Rowland John C. , Pearlman Eric M. 
Published: January 2022

AbstractObjectiveThe ObserVational survey of the Epidemiology, tReatment and Care of MigrainE (OVERCOME; United States) study is a multicohort, longitudinal web survey that assesses symptomatology, consulting, diagnosis, treatment, and impact of migraine in the United States.BackgroundRegularly updating population‐based views of migraine in the United States provides a method for assessing the quality of ongoing migraine care and identifying unmet needs.MethodsThe OVERCOME (US) 2018 migraine cohort involved: (I) creating a demographically representative sample of US adults using quota sampling (n = 97,478), (II) identifying people with active migraine in the past year via a validated migraine diagnostic questionnaire and/or self‐reported medical diagnosis of migraine (n = 24,272), and (III) assessing consultation, diagnosis, and treatment of migraine (n = 21,143). The current manuscript evaluated whether those with low frequency episodic migraine (LFEM; 0–3 monthly headache days) differed from other categories on outcomes of interest.ResultsAmong the migraine cohort (n = 21,143), 19,888 (94.1%) met our International Classification of Headache Disorders, 3rd edition‐based case definition of migraine and 12,905 (61.0%) self‐reported a medical diagnosis of migraine. Respondents’ mean (SD) age was 42.2 (15.0) years; 15,697 (74.2%) were women. Having at least moderate disability was common (n = 8965; 42.4%) and around half (n = 10,783; 51.0%) had consulted a medical professional for migraine care in the past year. Only 4792 (22.7%) of respondents were currently using a triptan. Overall, 8539 (40.4%) were eligible for migraine preventive medication and 3555 (16.8%) were currently using migraine preventive medication. Those with LFEM differed from moderate and high frequency episodic migraine and chronic migraine on nearly all measures of consulting, diagnosis, and treatment.ConclusionThe OVERCOME (US) 2018 cohort revealed slow but steady progress in diagnosis and preventive treatment of migraine. However, despite significant impact among the population, many with migraine have unmet needs related to consulting for migraine, migraine diagnosis, and getting potentially beneficial migraine treatment. Moreover, it demonstrated the heterogeneity and varying unmet needs within episodic migraine.
Interval appendicitis shows histological differences from acute appendicitis and may mimic Crohn disease and other forms of granulomatous appendicitis
Authors: Malvar Grace , Peric Masa , Gonzalez Raul S. 
Published: January 2022

AimsWhile patients presenting with clinical signs and symptoms of acute appendicitis (AA) often receive surgical intervention shortly after presentation, certain patients may instead receive non‐operative management initially, with appendectomy later. The histology of such interval appendicitis (IA) has only been described in small series. Also, we have noticed a recent increase in the incidence of IA specimens at our institution.Methods and resultsWe identified appendectomy specimens in our department during 2018 with available haematoxylin and eosin slides and electronic clinical data, and evaluated multiple histological findings. Cases were then divided into AA and IA, based on clinical history (AA if the patient presented to the hospital within 1 week of symptom onset and underwent appendectomy within 48 h; IA if appendectomy was delayed at least 1 week). Changes between groups were compared. The cohort included 165 cases (125 AA, 40 IA). Findings significantly more common in AA included mucosal acute inflammation, mural acute inflammation and acute serositis. Findings significantly more common in IA included Crohn‐like mural inflammation, mural fibrosis, goblet cell hyperplasia, granulomas, xanthogranulomatous inflammation, haemosiderin‐laden macrophages and granulation tissue. The rate of IA in 2018 (24%) was noticeably higher than in previous years.ConclusionAcute inflammatory changes are more common in AA but can remain present in IA. Mural fibrosis, serosal adhesions, haemosiderin‐laden macrophages and granulation tissue suggest IA. Granulomas and xanthogranulomatous inflammation can also be seen in IA, and Crohn‐like mural inflammation is not uncommon. These histological patterns can guide signout and prevent diagnostic errors, particularly when clinical information is unavailable.
Development and validation of a machine learning algorithm–based risk prediction model of pressure injury in the intensive care unit
Authors: Xu Jie , Chen Danxiang , Deng Xiaofang , Pan Xiaoyun , Chen Yu , Zhuang Xiaoming , Sun Caixia 
Published: January 2022

AbstractThe study aimed to establish a machine learning–based scoring nomogram for early recognition of likely pressure injuries in an intensive care unit (ICU) using large‐scale clinical data. A retrospective cohort study design was employed to develop and validate a top‐performing clinical feature panel accessibly in the electronic medical records (EMRs), which was in the mode of a quantifiable nomogram. Clinical factors regarding demographics, admission cause, clinical laboratory index, medical history and nursing scales were extracted as risk candidates. The performance improvement was based on the application of the machine learning technique, comprising logistic regression, decision tree and random forest algorithm with five‐fold cross‐validation (CV) technique. The comprehensive assessment of sensitivity, specificity and the area under the receiver operating characteristic curve (AUROC) was considered in the evaluation of predictive performance. The receiver operating characteristic curves revealed the top performance for the logistic regression model in respect to machine learning improvement, achieving the highest sensitivity and AUC among three types of classifiers. Compared against the 23‐point Braden scale routinely recorded online, an incorporated nomogram of logistic regression model and Braden scale achieved the best performance with an AUC of 0.87 ± 0.07 and 0.84 ± 0.05 in training and test cohort, respectively. Our findings suggest that the machine learning technique potentiated the limited predictive validity of routinely recorded clinical data on pressure injury development during ICU hospitalisation. Easily accessible electronic records held the potentials to substitute the traditional Braden score in the prediction of pressure injury in intensive care unit. Preoperative prediction of pressure injury facilitates the exemption from the severe consequences.
Invasion dynamics and potential future spread of sea spurge across Australia’s coastal dunes
Authors: Giulio Silvia , Cao Pinna Luigi , Carboni Marta , Marzialetti Flavio , Acosta Alicia Teresa Rosario , Garbolino Emmanuel , Jucker Tommaso 
Published: January 2022

AbstractAimInvasive species provide an opportunity to study biogeography in action, allowing us to observe how species adapt and fill their environmental niche when introduced to new ecological settings. Here we use sea spurge—a foredune specialist plant species native to Europe which has recently spread across Australia’s southern coasts—as a model system to explore species' environmental niches adaptations and potential for future spread following introduction outside their native range.LocationEurope and Australia.TaxonSea spurge, Euphorbia paralias, Euphorbiaceae.MethodsWe compiled presence‐absence data of E. paralias from >190,000 vegetation surveys in the native and invaded range. We combined presence‐absence data with information on climate, soil, coastal morphology and human pressure, to test whether E. paralias’ environmental niche has shifted following invasion and used species distributions models (SDMs) to map its invasion potential under current and future climatic conditions.ResultsThe environmental niche of E. paralias has shifted since reaching Australia, expanding into areas further away from people, closer to the shoreline and with higher temperatures. SDMs revealed that alongside broad‐scale gradients in temperature and rainfall, the distribution of E. paralias is also constrained by soil substrate and dune morphology—highlighting the importance of these fine‐scale drivers in shaping invasion dynamics in coastal environments. Moreover, SDMs suggest that future expansion in Australia will result from continued niche filling, not changes in climatic suitability.Main conclusionsDespite its impressive dispersal ability, E. paralias has not yet reached equilibrium in its invaded range and is likely to continue to expand its distribution in Australia regardless of climate change. E. paralias’ key to success has been its ability to suit novel environments. We provide one of the first examples of how to leverage distribution data and SDMs to test hypotheses about niche conservatism and expansion in coastal dune invasive plant species.
Single ring isolation for atrial fibrillation ablation: Impact of the learning curve
Authors: Thiyagarajah Anand , Mahajan Rajiv , Iwai Shinsuke , Gupta Aashray , Linz Dominik , Chim Ivana , Emami Mehrdad , Kadhim Kadhim , O'Shea Catherine , Middeldorp Melissa E. , Lau Dennis H. , Sanders Prashanthan 
Published: January 2022

AbstractIntroductionAlthough single ring isolation is an accepted strategy for undertaking pulmonary vein (PV) and posterior wall isolation (PWI) during atrial fibrillation (AF) ablation, the learning curve associated with this technique as well as procedural and clinical success rates have not been widely reported.Methods and ResultsProspectively collected data from 250 consecutive patients undergoing de novo AF ablation using single ring isolation. PWI was achieved in 212 patients (84.8%) and PV isolation without PWI was achieved in 37 patients (14.4%). Thirty‐one cases (12.4%) demonstrated inferior line sparing where PWI was achieved without a continuous posterior wall inferior line. A learning curve was observed, with higher rates of PWI (98% last 50 vs. 82% first 50 cases, p = .016), higher rates of inferior line sparing (20% last 50 vs. 8% first 50 cases, p = .071) and lower ablation times (43.8 min (interquartile range [IQR]: 34.6–57.0 min) last 50 versus. 96.5 min (IQR: 80.8–115.8 min) first 50 cases; p < .001). Three (1.3%) major procedure‐related complications were observed. Twelve‐month, single‐procedure freedom from atrial arrhythmia without drugs was 70.5% (95% confidence interval [CI]: 61.5%–77.7%) and 60.0% (95% CI: 50.2%–68.4%) for paroxysmal and persistent/longstanding persistent AF. Twelve‐month multi‐procedure freedom from atrial arrhythmia was 92.2% (95%CI: 85.6%–95.9%) and 85.6% (95%CI: 77.2%–91.0%) for paroxysmal and persistent/longstanding persistent AF.ConclusionEmploying a single ring isolation approach, PWI can be achieved in most cases. There is a substantial learning curve with higher rates of PWI, reduced ablation times, and higher rates of inferior line sparing as procedural experience grows. Long‐term freedom from arrhythmia is comparable to other AF ablation techniques.
Enhanced effect of recombinant adenoviruses co‐expression of ING4 and OSM on anti‐tumour activity of laryngeal cancer
Authors: Cheng Fuwei , Zhao Shuangping , Li Jiachen , Niu Yuyu , Huang Haiping , Yang Jicheng , Ma Shiyin , Liu Jisheng , Sun Peng 
Published: January 2022

AbstractThe inhibitor of growth family member 4 (ING4) is one of the ING family genes, serves as a repressor of angiogenesis or tumour growth and suppresses loss of contact inhibition. Oncostatin M (OSM) is a multifunctional cytokine that belongs to the interleukin (IL)‐6 subfamily with several biological activities. However, the role of recombinant adenoviruses co‐expressing ING4 and OSM (Ad‐ING4‐OSM) in anti‐tumour activity of laryngeal cancer has not yet been identified. Recombinant Ad‐ING4‐OSM was used to evaluate their combined effect on enhanced anti‐tumour activity in Hep‐2 cells of laryngeal cancer in vivo. Moreover, in vitro function assays of co‐expression of Ad‐ING4‐OSM were performed to explore impact of co‐expression of Ad‐ING4‐OSM on biological phenotype of laryngeal cancer cell line, that is Hep‐2 cells. In vitro, Ad‐ING4‐OSM significantly inhibited the growth, enhanced apoptosis, altered cell cycle with G1 and G2/M phase arrest, and upregulated the expression of P21, P27, P53 and downregulated survivin in laryngeal cancer Hep‐2 cells. Furthermore, in vivo functional experiments of co‐expressing of Ad‐ING4‐OSM demonstrated that solid tumours in the nude mouse model were significantly suppressed, and the co‐expressing Ad‐ING4‐OSM showed a significant upregulation expression of P21, P53, Bax and Caspase‐3 and a downregulation of Cox‐2, Bcl‐2 and CD34. This study for the first time demonstrated the clinical value and the role of co‐expressing Ad‐ING4‐OSM in biological function of laryngeal cancer. This work suggested that co‐expressing Ad‐ING4‐OSM might serve as a potential therapeutic target for laryngeal cancer patients.
Completing Banking Union? The Role of National Deposit Guarantee Schemes in Shifting Member States' Preferences on the European Deposit Insurance Scheme
Authors: Tümmler Mario 
Published: January 2022

AbstractThe gridlock on the European deposit insurance scheme (EDIS), the missing pillar of the banking union, is most commonly attributed to moral hazard concerns on the side of Germany. However, Member State preferences on EDIS cannot be understood solely based on concerns over pre‐emptive risk reduction. Instead, banking sector interests connected to the institutional setup and legal status of national deposit guarantee schemes (DGSs) have also informed these preferences. This article examines the development of preference formation on EDIS for the cases of Germany, Italy and France after the initial 2015 proposal failed. National preferences on the institutional setup of EDIS have become more aligned with a reinsurance system that maintains existing DGS. Hence, current trajectories point to a discussion over how national DGSs are to be linked in a reinsurance system, instead of a discussion about whether it should be abandoned or not.
Impact of newly diagnosed diabetes on coronavirus disease 2019 severity and hyperglycemia
Authors: Uchihara Masaki , Bouchi Ryotaro , Kodani Noriko , Saito Sho , Miyazato Yusuke , Umamoto Kotaro , Sugimoto Hirofumi , Kobayashi Michi , Hikida Sayaka , Akiyama Yutaro , Ihana‐Sugiyama Noriko , Ohsugi Mitsuru , Tanabe Akiyo , Ueki Kohjiro , Takasaki Jin , Hojo Masayuki , Kajio Hiroshi 
Published: January 2022

ABSTRACTAims/IntroductionDiabetes is associated with poor clinical outcomes of coronavirus disease 2019 (COVID‐19). However, the impact of newly diagnosed diabetes on prognosis has not been clarified. The objective of this study was to show the features and outcome of COVID‐19 patients with newly diagnosed diabetes in Japan.Materials and MethodsWe retrospectively analyzed 62 patients with diabetes hospitalized for COVID‐19 between 1 April and 18 August 2021 at the National Center for Global Health and Medicine in Tokyo, Japan. We evaluated the worst severity of COVID‐19 and plasma blood glucose levels in patients with newly diagnosed diabetes or pre‐existing diabetes.ResultsThis study included 62 confirmed COVID‐19 patients with diabetes, including 19 (30.6%) patients with newly diagnosed diabetes and 43 (69.4%) patients with pre‐existing diabetes. Patients with newly diagnosed diabetes significantly progressed to a critical condition more frequently during hospitalization than patients with pre‐existing diabetes (52.6% vs 20.9%, P = 0.018). In addition, patients with newly diagnosed diabetes had significantly higher average plasma blood glucose levels for the first 3 days after admission than those with pre‐existing diabetes.ConclusionsOur study suggests that the proportion of COVID‐19 patients who are newly diagnosed with diabetes is high, and they have an increased risk of developing severe disease than those with pre‐existing diabetes. It might be advisable that at the point of COVID‐19 diagnosis, blood glucose and glycated hemoglobin levels be assessed in all patients.
Drying kinetics, performance, and quality assessment for banana slices using heat pump–assisted drying system (HPADS)
Authors: Kushwah Anand , Kumar Anil , Gaur Manoj Kumar 
Published: January 2022

AbstractIn the present work, fresh banana slices were dehydrated at various drying air temperatures (35, 40, and 45°C) using novel heat pump–assisted drying system (HPADS) operating in a close loop. Drying air temperature significantly influences the drying time; as the drying temperature increases, drying time is reduced linearly. Increase in slice thickness of the sample increases drying time. Verma et al.'s model was considered to select the best fit model and describe the actual data. Effective moisture diffusivity varied from 1.05 × 10−10 to 1.56 × 10−10 m2/s at temperatures 35 and 45°C, respectively. Arrhenius equation was used to correlate the dependency of moisture diffusivity with temperature and activation energy found to be 42.58 kJ/mol. Water activity (Aw) varied from 0.750 to 0.577 at temperatures 35 and 45°C, respectively. Hence, for Aw < 0.6 at 45°C drying temperature, micro‐organisms can no longer extract water for their growth, and enzymes become inactive. Specific moisture removal ratio and coefficient of performance of system were found to be 0.230 kg/kWh and 3.168, correspondingly, at maximum temperature (45°C). Therefore, a developed novel HPADS is recommended for small farmers and cottage industries.Practical ApplicationsIt is more reliable to dry agricultural products with high moisture content inside the novel heat pump assisted drying system. The developed drying system is recommended for small farmers or cottage industries. This study will be constructive for further research work on such drying systems.
Efficacy of ablative fractional carbon dioxide laser combined with autologous platelet‐rich plasma versus ablative fractional carbon dioxide laser and placebo in the treatment of striae gravidarum: A randomized clinical trial
Authors: Preclaro Ivan Arni C. , Tianco Elizabeth Amelia V. , Buenviaje‐Beloso Mercedes 
Published: January 2022

AbstractBackgroundStriae gravidarum (SG) is a connective tissue disorder seen commonly in primigravidas. It is associated with impairment in the quality of life.ObjectiveTo determine the efficacy of ablative fractional carbon dioxide (CO2) laser combined with autologous platelet‐rich plasma (PRP) versus ablative fractional CO2 laser and placebo in the treatment of SG.Study designRandomized, double‐blinded, and placebo‐controlled trial.MethodologyThe study was conducted in 16 patients with SG. The assigned treatment area (abdomen) was divided into two sides and was randomly assigned to the PRP side and the control side. All patients received ablative fractional CO2 laser. Immediately after each laser procedure, the PRP side received autologous PRP, while the control side received plain normal saline solution (pNSS) as a placebo. The study was done for three sessions, at intervals of 4 weeks. An independent assessor used the photographs taken at Weeks 6, 10, 14, and 16 to assess the clinical improvement. The patient satisfaction was reported at the same intervals. A quartile grading scale was used to measure both the clinical improvement and patient satisfaction. Data were analyzed using the Jonckheere–Terpstra test. Histopathology was done before treatment and at the end of the study period.ResultsThe combination of ablative fractional CO2 laser and autologous PRP had better clinical improvement and patients’ satisfaction compared with ablative fractional CO2 laser and placebo. However, both outcome measures were not statistically significant.ConclusionAblative fractional CO2 laser combined with autologous PRP appears to be an effective treatment in SG.
Impact of IPL treatments on parameters of acne skin
Authors: Zdrada Julita , Stolecka‐Warzecha Anna , Odrzywołek Wiktoria , Deda Anna , Błońska‐Fajfrowska Barbara , Wilczyński Sławomir 
Published: January 2022

AbstractBackgroundIn the treatment of acne, skin parameters such as sebum secretion, hydration, and the content of hemoglobin and melanin are very important. The values of these parameters at the appropriate level show the maintenance of good functionality of the epidermal barrier and the impact of a given treatment procedure on the condition and physiology of the epidermis.AimsThe aim of the study was to evaluate the effectiveness of anti‐acne therapy with IPL by volunteers, as well as to quantify parameters such as sebum secretion, hydration level, and the content of melanin and hemoglobin in the skin.Patients/MethodsThe study involved 27 volunteers with moderate acne. A series of 4 treatments was performed with intense pulse light at weekly intervals. The secretion of sebum, skin hydration, and the content of melanin and hemoglobin was measured.ResultsA decrease in sebum secretion in the forehead area after light treatments was observed, the level of hydration remained the same in all areas examined, as did the levels of melanin and hemoglobin. The volunteers were asked about the satisfaction with the effects of the treatment: 100% answered that they were satisfied with the effects of the treatment to a degree of 7.8 ± 1.5.ConclusionsDuring anti‐acne therapy, therapists usually focus only on reducing acne lesions, forgetting that proper care has a large impact on the success of dermatological therapies. It is very important to know the influence of treatment procedures on the parameters of the skin in order to choose the right care for the best treatment effect.
Factors Related to Concussion Knowledge, Attitudes, and Reporting Behaviors in US High School Athletes: A Systematic Review
Authors: Beran Krista M. , Scafide Katherine N. 
Published: January 2022

ABSTRACTBACKGROUNDSport‐related concussions are a major public health problem with only 50% of concussed teens reporting their symptoms. The purpose of this systematic review was to identify individual and institutional factors that contribute to concussion knowledge, attitude, and reporting behaviors among US high school athletes.METHODSThe Preferred Reporting Items for Systematic Reviews and Meta‐Analysis protocol was used to direct the process of this systematic review. A search for English, peer‐reviewed, quantitative studies published between 2010 and 2020 was conducted in 5 scholarly databases. The Joanna Briggs Critical Appraisal Tools were used to assess study quality.RESULTSTwenty‐two studies met criteria for inclusion in this systematic review. The study designs were mostly cross‐sectional (N = 18). Synthesis revealed individual factors including gender, age, race/ethnicity, grade level, and concussion history were associated with differences in concussion knowledge, attitude, and/or reporting behaviors. Institutional factors identified included school location, concussion education, access to an athletic trainer, sport played, and team climate. Six studies found concussion education had a positive impact on knowledge and reporting behaviors.CONCLUSIONThis systematic review identified certain populations which may be more vulnerable to underreporting concussion symptoms; therefore, a targeted approach to education and management may be more effective.