bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of a single-dose denosumab on semen quality in infertile men (the FITMI study): study protocol for a randomized controlled trial
Authors: Yahyavi Sam Kafai , Holt Rune , Juel Mortensen Li , Petersen Jørgen Holm , Jørgensen Niels , Juul Anders , Blomberg Jensen Martin 
Published: June 2022

Abstract
Background
Infertility is a common problem globally and impaired semen quality is responsible for up to 40% of all cases. Almost all infertile couples are treated with either insemination or assisted reproductive techniques (ARTs) independent of the etiology of infertility because no medical treatment exists. Denosumab is an antibody that blocks RANKL signaling and inhibition of testicular RANKL signaling has been suggested to improve semen quality in a pilot study. This RCT aims to assess whether treatment with denosumab can improve spermatogenesis in infertile men selected by serum AMH as a positive predictive biomarker. This paper describes the design of the study.

Methods/design
FITMI is a sponsor-investigator-initiated, double-blinded, placebo-controlled 1:1, single-center, randomized clinical trial. Subjects will be randomized to receive either a single-dose denosumab 60 mg subcutaneous injection or placebo. The study will be carried out at the Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen. The primary outcome of the study is defined as the difference in sperm concentration (millions pr. mL) one spermatogenesis (80 days) after inclusion.

Discussion
We describe a protocol for a planned RCT aimed at evaluating whether treatment with denosumab can improve the semen quality in infertile men selected by using serum AMH as a positive predictive biomarker. The results will provide evidence crucial for future treatment in a patient group where there is a huge unmet need.

Trial registration
Clinical Trials.gov NCT05212337. Registered on 14 January 2022.
EudraCT 2021–003,451-42. Registered on 23 June 2021.
Ethical committee H-21040145. Registered on 23 December 2021.
Maternal epigenetic clocks measured during pregnancy do not predict gestational age at delivery or offspring birth outcomes: a replication study in metropolitan Cebu, Philippines
Authors: Ryan Calen P. , Rege Raviraj J. , Lee Nanette R. , Carba Delia B. , Kobor Michael S. , MacIsaac Julie L. , Lin David S. , Atashzay Parmida , Kuzawa Christopher W. 
Published: June 2022

AbstractAdverse birth outcomes, such as early gestational age and low birth weight, can have lasting effects on morbidity and mortality, with impacts that persist into adulthood. Identifying the maternal factors that contribute to adverse birth outcomes in the next generation is thus a priority. Epigenetic clocks, which have emerged as powerful tools for quantifying biological aging and various dimensions of physiological dysregulation, hold promise for clarifying relationships between maternal biology and infant health, including the maternal factors or states that predict birth outcomes. Nevertheless, studies exploring the relationship between maternal epigenetic age and birth outcomes remain few. Here, we attempt to replicate a series of analyses previously reported in a US-based sample, using a larger similarly aged sample (n = 296) of participants of a long-running study in the Philippines. New pregnancies were identified prospectively, dried blood spot samples were collected during the third trimester, and information was obtained on gestational age at delivery and offspring weight after birth. Genome-wide DNA methylation was assessed with the Infinium EPIC array. Using a suite of 15 epigenetic clocks, we only found one significant relationship: advanced age on the epigenetic clock trained on leptin predicted a significantly earlier gestational age at delivery (β = − 0.15, p = 0.009). Of the other 29 relationships tested predicting gestational age and offspring birth weight, none were statistically significant. In this sample of Filipino women, epigenetic clocks capturing multiple dimensions of biology and health do not predict birth outcomes in offspring.
Evaluating a pre-surgical health optimisation programme: a feasibility study
Authors: McLaughlin Joanna , Scott Lauren J. , Owens Lucie , McLeod Hugh , Sillero-Rejon Carlos , Reynolds Rebecca , Owen-Smith Amanda , Hill Elizabeth M. , Jago Russell , Donovan Jenny L. , Redwood Sabi , Kipping Ruth 
Published: June 2022

Abstract
Background
Health optimisation programmes are increasingly popular and aim to support patients to lose weight or stop smoking ahead of surgery, yet there is little published evidence about their impact. This study aimed to assess the feasibility of evaluating a programme introduced by a National Health Service (NHS) clinical commissioning group offering support to smokers/obese patients in an extra 3 months prior to the elective hip/knee surgery pathway.

Methods
Feasibility study mapping routinely collected data sources, availability and completeness for 502 patients referred to the hip/knee pathway in February–July 2018.

Results
Data collation across seven sources was complex. Data completeness for smoking and ethnicity was poor. While 37% (184) of patients were eligible for health optimisation, only 28% of this comparatively deprived patient group accepted referral to the support offered. Patients who accepted referral to support and completed the programme had a larger median reduction in BMI than those who did not accept referral (− 1.8 BMI points vs. − 0.5). Forty-nine per cent of patients who accepted support were subsequently referred to surgery, compared to 61% who did not accept referral to support.

Conclusions
Use of routinely collected data to evaluate health optimisation programmes is feasible though demanding. Indications of the positive effects of health optimisation interventions from this study and existing literature suggest that the challenge of programme evaluation should be prioritised; longer-term evaluation of costs and outcomes is warranted to inform health optimisation policy development.
Islamic copper-based metal artefacts from the Garb al-Andalus. A multidisciplinary approach on the Alcáçova of Mārtulah (Mértola, South of Portugal)
Authors: Bottaini Carlo , Martínez Susana Gómez , Bordalo Rui , Beltrame Massimo , Mirão José , Rafael Lígia , Schiavon Nick 
Published: June 2022

Abstract
A multidisciplinary approach has been applied to investigate the production technology of a collection of copper-based artefacts found during archaeological excavation campaigns carried out in the Almohad neighbourhood of Mārtulah, the Islamic name of modern Mértola (South of Portugal). In stark contrast to other Islamic materials found in the same site such as common and finely decorated pottery, glass, and bone artefacts, metal objects have received less attention despite the high number of artefacts recovered.
This study focuses on the chemical characterisation of 171 copper-based artefacts dating back to the 12th and the first half of the thirteenth centuries. The artefacts are daily use objects and consist of personal ornaments (earrings, rings, and casket ornaments), tools (spindles, spatulas, and oil lamp sticks) and artefacts with unknown functions. The analytical results by X-ray fluorescence Spectroscopy (XRF) provided information not only about technological issues but infer as well on the socio-economic implications of metal consumption in Islamic Mértola. Results revealed that metals were produced using a variety of Cu-based alloys, namely unalloyed copper, brasses (Cu + Zn), bronzes (Cu + Sn), and red brasses (Cu + Sn + Zn), with a variable concentration of Pb, without any apparent consistency, as a likely result of recurrent recycling and mixing scrap metals practices or use of mineral raw materials available locally.
Noninvasive identification of Benign and malignant eyelid tumors using clinical images via deep learning system
Authors: Hui Shiqi , Dong Li , Zhang Kai , Nie Zihan , Jiang Xue , Li Heyan , Hou Zhijia , Ding Jingwen , Wang Yue , Li Dongmei 
Published: June 2022

AbstractEyelid tumors accounts for 5–10% of skin tumors. It is important but difficult to identify malignant eyelid tumors from benign lesions in a cost-effective way. Traditional screening methods for malignancy in eyelid tumors require laborious and time-consuming histopathological process. Therefore, we aimed to develop a deep learning (DL)-based image analysis system for automatic identification of benign and malignant eyelid tumors. Using a common digital camera, we collected clinical images from patients who were histopathologically diagnosed with eyelid tumors. We trained 8 convolutional neural network (CNN) models to identify benign and malignant eyelid tumors, including ResNet-50, ResNet-101, InceptionV3, and InceptionResNetV2. Another group of patients with eyelid tumors were also collected as the prospective validation dataset. Performance of DL models and human clinicians in prospective validation dataset were evaluated and compared. A total of 309 images from 209 patients were used for training DL system, all eight models reached an average accuracy greater than 0.958 in the internal cross-validation. 36 images from 36 patients were included for the prospective validation, the models reached the best performance in accuracy, sensitivity, specificity, and area under curve (AUC) of 0.889 (95% CI 0.747–0.956), 0.933 (95% CI 0.702–0.988), 0.857 (95% CI 0.654–0.950), and 0.966 (95% CI 0.850–0.993), respectively. DL system had a similar performance as the senior ophthalmologists, and outreached the performance of junior ophthalmologists and medical students. DL system can identify benign and malignant tumors through common clinical images, with a better performance than most ophthalmologists. Combining DL system with smartphone may enable patients’ self-monitoring for eyelid tumors and assist in doctors’ clinical decision making.
Geotechnical modelling and subsurface analysis of complex underground structures using PLAXIS 3D
Authors: Hemeda Sayed 
Published: June 2022

AbstractIn this study, analysis of complicated underground structure of Horemheb tomb (KV57) at Luxor, Egypt by using the software PLAXIS 3D is adopted and the deformation that occurs in the body of the underground structure after applied the failure load detected; the failure loads are obtained from the series of laboratory tests. Then, the structure is modelled by using finite element code to perform accurate three-dimensional analysis of deformation and stability in complex geotechnical engineering and rock mechanics. These underground monumental structures have been analyzed by finite element method FEM to obtain the deformation that accrued into the structure and so beneath of the surface and calculated the effective stress, shear stress and horizontal displacements. In order to modeling requires the soil parameters obtained from laboratorial tests. In the analysis elastic–plastic Mohr–Coulomb model is used as material model. It involves five parameters namely, Young’s Modulus (E) and poison’s ratio (ν) for soil elasticity, friction angle (φ) and cohesion (c) for soil plasticity. To set up the boundary condition, the standard fixities option is used. As a result a full fixity at the base and free condition at the horizontal side of geometry are generated. Numerical Engineering analysis for Horemheb tomb (KV57) in the valley of kings at the west bank of Luxor was carried out through the following four main steps: (1) Evaluation of surrounding rocks (marl limestone and marl shale) by experimental research and Roclab program to obtain the Hoek Brown and Mohr- Coulomb fit classification criterion and rock mass standards in particular the global strength and deformation coefficient. Also to specify the main characteristics of the Esna Shale using different methods such as swelling test, swelling potential, swelling pressure, in addition, discussion of the role of the expansive Esna Shale in the deterioration of archaeological buildings and sites. (2) Quantitative and qualitative estimates of the relevant factors affecting the stability of the tomb, especially overloading, fixed, geographic, and dynamic. (3) Integrated 3D geotechnical modeling of the cemetery environment for stress and displacement analysis and identification of volumetric strains and plastic points using advanced symbols and programs such as PLAXIS 3D. (4) The rapeutic and retrofit policies and techniques and the fixed monitoring and control systems needed to strengthen and stabilize the cemetery, where the rock mass classification refers to the rock mass where KV57 is excavated and it is poor rocks. The mechanical behavior of the rocks is simulated by assuming a foundational model to soften the elastic stress of the flexible plastic that captures fragile failure and the mechanisms of progressive substrate failure. In addition, rock pillar treatments and ground support strategies are discussed. This article represents the second phase of the numerical analysis of KV57 using PLAXIS 3D.
Emergency open drainage of massive hemoperitoneum and early stage left hepatectomy for abdominal compartment syndrome due to hepatocellular carcinoma rupture: a case report
Authors: Kurimoto Makoto , Yamanaka Kenya , Hirata Masaaki , Umeda Makoto , Yamashita Tokuyuki , Aoki Hikaru , Hanabata Yusuke , Shinkura Akina , Tamura Jun 
Published: June 2022

Abstract
Background
Spontaneous rupture is one of the most life-threatening complications of hepatocellular carcinoma (HCC). Transcatheter arterial embolization (TAE) effectively achieves hemostasis in patients with hemodynamic instability. However, there have been no reports of abdominal compartment syndrome (ACS) caused by massive intra-abdominal hematoma after TAE. We report emergency open drainage of a massive hematoma for abdominal decompression and early stage left hepatectomy at the same time.

Case presentation
A 75-year-old woman was transported to our emergency department with hypovolemic shock. Dynamic contrast-enhanced computed tomography revealed extravasation of contrast medium from a HCC lesion in the medial segment of the liver and a large amount of high-density ascites. TAE was immediately performed to achieve hemostasis. Three hours after the first TAE, we decided to perform a second TAE for recurrent bleeding. After the second TAE, the patient’s intra-abdominal pressure increased to 35 mmHg, her blood pressure gradually decreased, and she had anuria. Thus, she was diagnosed with ACS due to spontaneous HCC rupture. Twenty-seven hours after her arrival to the hospital, we decided to perform open drainage of the massive hematoma and left hepatectomy for ACS relief, prevention of re-bleeding, tumor resection, and intraperitoneal lavage. The operative duration was 225 min, and the blood loss volume was 4626 g. Postoperative complications included pleural effusion and grade B liver failure. She was discharged on postoperative day 33. The patient survived for more than 3 years without functional deterioration.

Conclusions
Even after hemostasis is achieved by TAE for hemorrhagic shock due to spontaneous rupture of HCC, massive hemoperitoneum may lead to ACS, particularly in cases of re-bleeding. Considering the subsequent possibility of ACS and the recurrence of bleeding, early stage hepatectomy and removal of intra-abdominal hematoma after hemodynamic stabilization could be a treatment option for HCC rupture.
Mechanical behavior of stretchable conductive materials based on elastomeric core: experimental and theoretical simulation
Authors: Bar Avia J. , Mead Joey , Dodiuk Hanna , Kenig Samuel 
Published: June 2022

AbstractThe mechanical behavior of braided carbon nanotube yarns (CNTYs) on an elastomeric core to produce stretchable conductive materials were theoretically modeled and experimentally studied under tension. The elastomeric core served as the stretchable spring and the CNTYs braiding, with shape changing capabilities, as the conductive shell. A variety of samples were produced having various braiding angles on an elastomeric core and subsequently loaded in tension, and their stress–strain behavior was characterized. The model predicts the stress–strain behavior of the composite as a function of the initial braiding angle and the number of pitches. The innovative aspect was included in the model related to the friction between the braid and the core. Results indicated good agreement between the theoretical simulations and the experimental results which was not discussed in previous studies. Since the rate of the diameter decrease of the CNTYs braid was higher than that of the elastomeric core diameter, squeezing out of the core through the braid inter yarn space occurred. This limited the maximum potential extension of the braid. Thus, a critical strain was defined where the braid came into contact with the core. The addition of the friction stresses made a significant contribution to the overall stresses and the accuracy of the theoretical simulation, and its agreement with the experimental results. An apparent friction coefficient was proposed to account for the effect of the elastomer core/braid interactive restriction and squeezing out of the elastomer through the braiding, as observed in experimental results. As the CNTYs are conductive, a stretchable conductive composite was obtained having a resistivity of 9.05 × 10–4 Ohm*cm, which remained constant throughout the tensile loading until failure and under cyclic loading.
Curve intersection based on cubic hybrid clipping
Authors: Wu Yaqiong , Li Xin 
Published: June 2022

AbstractThis study presents a novel approach to computing all intersections between two Bézier curves using cubic hybrid clipping. Each intersection is represented by two strip intervals that contain an intersection. In each step, one curve is bounded by two fat lines, and the other is bounded by two cubic Bézier curves, clipping away the domain that does not contain the intersections. By selecting the moving control points of the cubic hybrid curves, better cubic polynomial bounds are obtained to make the proposed method more efficient. It was proved that the two strip intervals have second- and fourth-order convergence rates for transversal intersections. Experimental results show that the new algorithm is the most efficient among all existing curve/curve intersection approaches.
Mental disorders into adulthood among adolescents placed in residential care: A prospective 10-year follow-up study
Authors: Seker Süheyla , Boonmann Cyril , d’Huart Delfine , Bürgin David , Schmeck Klaus , Jenkel Nils , Steppan Martin , Grob Alexander , Forsman Hilma , Fegert Jörg M. , Schmid Marc 
Published: June 2022

AbstractBackgroundChild welfare and juvenile justice placed youths show high levels of psychosocial burden and high rates of mental disorders. It remains unclear how mental disorders develop into adulthood in these populations. The aim was to present the rates of mental disorders in adolescence and adulthood in child welfare and juvenile justice samples and to examine their mental health trajectories from adolescence into adulthood.MethodsSeventy adolescents in shared residential care, placed by child welfare (n = 52, mean age = 15 years) or juvenile justice (n = 18, mean age = 17 years) authorities, were followed up into adulthood (child welfare: mean age = 25 years; juvenile justice: mean age = 27 years). Mental disorders were assessed based on the International Classification of Diseases 10th Revision diagnoses at baseline and at follow-up. Epidemiological information on mental disorders was presented for each group. Bivariate correlations and structural equation modeling for the relationship of mental disorders were performed.ResultsIn the total sample, prevalence rates of 73% and 86% for any mental disorder were found in adolescence (child welfare: 70%; juvenile justice: 83%) and adulthood (child welfare: 83%; juvenile justice: 94%) respectively. General psychopathology was found to be stable from adolescence into adulthood in both samples.ConclusionsOur findings showed high prevalence rates and a high stability of general psychopathology into adulthood among child welfare and juvenile justice adolescents in Swiss residential care. Therefore, continuity of mental health care and well-prepared transitions into adulthood for such individuals is highly warranted.
Burden of Long-Term Morbidity Borne by Survivors of Acute Myeloid Leukemia Treated With Blood or Marrow Transplantation: The Results of the BMT Survivor Study
Authors: Armenian Saro H. , Chen Yanjun , Hageman Lindsay , Wu Jessica , Landier Wendy , Bosworth Alysia , Francisco Liton , Schlichting Elizabeth , Bhatia Ravi , Salzman Donna , Wong F. Lennie , Weisdorf Daniel J. , Forman Stephen J. , Arora Mukta , Bhatia Smita 
Published: June 2022

PURPOSE Blood or marrow transplantation (BMT) is an integral part of consolidation and/or salvage therapy for patients with acute myeloid leukemia (AML). With the growing population of AML survivors, there is a need to understand the quality of their survival. MATERIALS AND METHODS This multisite study included 1,369 2-year survivors who underwent BMT for AML between 1974 and 2014 at age ≥ 21 years and 1,310 siblings. Using Common Terminology Criteria for Adverse Events, severe/life-threatening and fatal chronic health conditions were identified. Multivariable regression analysis was used to compare the risk of severe/life-threatening conditions and health status between survivors and siblings, and to identify risk factors for health conditions among BMT survivors. RESULTS The prevalence of severe/life-threatening conditions was 54.9% in BMT survivors compared with 28.5% in siblings ( P < .001), yielding 3.8-fold higher odds of severe/life-threatening conditions (95% CI, 3.1 to 4.7) among the BMT survivors. The most prevalent conditions included subsequent neoplasms, diabetes, cataracts, venous thromboembolism, and joint replacement. Survivors were more likely to report poor general health (odds ratio [OR], 3.8; 95% CI, 2.8 to 5.1), activity limitation (OR, 3.7; 95% CI, 3.0 to 4.5), and functional impairment (OR, 2.9; 95% CI, 2.3 to 3.6). Among BMT recipients, the 20-year cumulative incidence of severe/life-threatening/fatal conditions was 68%. History of chronic graft-versus-host disease was associated with a higher risk of pulmonary disease (hazard ratio [HR], 3.1; 95% CI, 1.0 to 9.3), cataract (HR, 2.6; 95% CI, 1.4 to 3.8), and venous thromboembolism (HR, 2.3; 95% CI, 1.3 to 4.7). Relapse-related mortality (RRM) plateaued at 30%, whereas non-RRM increased to 50% at 30 years. CONCLUSION The burden of severe/life-threatening conditions is substantially higher in BMT recipients when compared with an unaffected comparison group, contributing to an increasing incidence of non-RRM over time. Chronic graft-versus-host disease was an important risk factor for severe/life-threatening/fatal conditions among BMT recipients, informing the need for close monitoring to anticipate and manage morbidity.