bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of eco‐friendly bio‐composite by reinforcing pineapple fruit waste crown fiber to ethylene‐propylene rubber modified polyethylene
Authors: Kumar Jitendra , Maurya Atul Kumar , Gupta Hariome Sharan , Singh Surendra Pal , Sharma Chhaya 
Published: August 2022

AbstractCurrent study discovers society's pineapple waste management issue a new approach. The pineapple crown fiber (PACF) has been used as reinforcement into a maleic anhydride (MAH) grafted ethylene‐propylene rubber (EPR) modified low‐density polyethylene (LDPE). The PACF reinforced composites with 10 wt% EPR content showed much better mechanical properties than the tensile and flexural properties demonstrated by the composites consisting of only PACF and LDPE only. The highest tensile strength (~29 MPa) and modulus of elasticity (~851 MPa) were obtained for the composite consisting of 30 wt% of PACF in the base matrix. Similarly, the highest flexural strength (~27 MPa) and modulus (~1814 MPa) were recorded for the same composition. Attenuated total reflection‐infrared spectroscopy confirmed a new bond between PACF and base matrix, establishing good compatibility between PACF and base matrix. The morphological analysis gives an insight of the microstructure and fracture behavior of the composites, which confirms an excellent wetting of the fibers by the base matrix. Thermogravimetry of the composites showed the increment in the PACF content decreased the thermal degradation temperature of the composites. DMA and differential scanning calorimetry demonstrated an increment into the storage modulus and crystallization temperature of all the composites compared to pristine LDPE.
Sustainable recycling technologies for thermoplastic polymers and their composites: A review of the state of the art
Authors: Jagadeesh Praveenkumara , Mavinkere Rangappa Sanjay , Siengchin Suchart , Puttegowda Madhu , Thiagamani Senthil Muthu Kumar , G. Rajeshkumar , Hemath Kumar Mohit , Oladijo Oluseyi Philip , Fiore Vincenzo , Moure Cuadrado Marta María 
Published: August 2022

AbstractThis review article discusses the environmental and economic effects of recycling, as well as sustainable thermoplastic polymer recycling technologies. Several researchers have utilized recycled thermoplastics as matrices in the production of a variety of natural and synthetic‐based composites, which is also the focus of this study. All of the industries (food and packaging, construction and building, transportation, and indoor usage) where recycled thermoplastics have a large market share (food and packaging, construction and building, transportation, and indoor usage) are covered in this review. The desirable properties of thermoplastic polymers, such as corrosion resistance, low density, and user‐friendliness, have caused plastic production to surpass aluminum and other metals in use over the past 60 years. Furthermore, recycling is one of the most important measures available to mitigate these effects and is one of the most dynamic segments of the plastics industry at present. Increased landfilling and incineration of plastics have a negative impact on the ecosystem, and the continued increase in the production of virgin fossil plastic also has a negative impact on the environment. Consequently, this continuous production could lead to the depletion of fossil fuel resources, an increase in environmental emissions during processing, and eventual incineration. Increasing numbers of nations are adopting the circular economy concept in an effort to avoid all of these problems. This concept emphasizes the reuse of products and resources, as well as the recycling of materials according to the waste hierarchy, rather than their cremation or disposal in the environment.
Innovation in fetal surgery: Use of vascular plugs in placental chorioangioma with fetal hydrops
Authors: Sanz Cortes Magdalena , Bechtold Hunter , Qureshi Athar M. , Justino Henri , Espinoza Jimmy , Nassr Ahmed A. , Donepudi Roopali , Castro Eumenia , Furtun Betul Yilmaz , Ayres Nancy , Belfort Michael , Shamshirsaz Alireza 
Published: August 2022

Key pointsWhat does this study add?

This study reports a novel approach for in utero treatment of chorioangiomas using a needle‐based ultrasound‐guided procedure to deploy vascular plugs to abolish tumoral flow in the placenta.

What is already known?

There is limited experience with in utero treatment of placental chorioangiomas. Different strategies have been proposed with different risks and benefits. Interventions with coils have yielded mixed results but are nonetheless promising, given the simplicity and relative safety of the procedure.
Longitudinal investigation of suicidal ideation and associated factors during pediatric acute lymphoblastic leukemia chemotherapy
Authors: Raghubar Kimberly P. , Chambers Tiffany , Hill Ryan M. , Taylor Olga , Hockenberry Marilyn , Hooke M. Casey , Mitby Pauline , Moore Ida Ki , Brown Austin L. , Scheurer Michael E. 
Published: August 2022

AbstractObjectiveThis study describes the prevalence of suicidal ideation (SI) during acute lymphoblastic leukemia (ALL) therapy and investigates the influence of clinical factors and physical symptoms on SI.MethodsThe Children's Depressive Inventory (CDI‐2) was administered to ALL patients (diagnosed 2012–2017) at start of consolidation, delayed intensification (DI), maintenance cycle 1 (MC1), and maintenance cycle 2 (MC2) in a multi‐site study. SI was present if patients endorsed the item “I want to kill myself.” Logistic regression models evaluated associations between SI and sociodemographic factors; depressive symptoms; and below average, average, and above average symptom clusters identified using latent class analysis of pain, nausea, fatigue, and sleep.ResultsParticipants (n = 175) were 51% male, 75% high‐/very high‐risk disease, with a median age of 11.2 years at diagnosis (range: 7–18 years). Overall, 14.9% of patients (75% under age 12 years) endorsed SI during treatment, including 4% at start of consolidation, 9% at DI, 8% at MC1, and 4% at MC2. Non‐Hispanic Other patients were 10.9‐times (95% CI: 2.30–53.40) more likely than non‐Hispanic Whites to endorse SI (p = 0.003). The frequency of SI was higher in patients experiencing above average (53.3%) compared to below average (4.1%, p = 0.003) symptoms. Depressive symptoms were consistently associated with SI.ConclusionsSI during the initial year of childhood ALL was more prevalent in children under the age of 12 years, from ethnic groups not typically associated with increased risk, and who endorsed increased physical and depressive symptoms. Findings highlight the need for improved screening of mental health problems to mitigate symptoms of distress.
Perceived psychosexual dimensions of cervical cancer survivors in India—An exploratory study
Authors: Rajkumar Divya , Veeraiah Surendran , Sudhakar Revathy , Ganeshrajah Selvaluxmy 
Published: August 2022

AbstractObjectiveCervical cancer is the second most common cancer among women in India. Medical advancements have led to increased survival. However, sexuality and sexual concerns remain as major worries of patients after treatment. This study aims to understand the psychosexual experiences of cervical cancer survivors.MethodsCervical cancer survivors (n = 30) aged 35–55 years were interviewed using a semi‐structured interview schedule, after obtaining consent. The audio‐recorded in‐depth interviews were transcribed and analysed using thematic analysis.ResultsThree major themes in each group namely sexually active and sexually inactive evolved on analysis. Three themes were derived under sexually active group namely (i) Enablers of active sexual functioning (ii) Impediments of active sexual functioning (iii) Sexual health communication. The three themes under sexually inactive include (i) Attributes of sexual abstinence (ii) Impact of sexual abstinence (iii) Barriers of sexual health communication.ConclusionsBoth sexually active and inactive survivors in India experience various psychosexual concerns post cancer treatment indicating a strong need for psychosocial care and focused clinical interventions.
Antifungal mechanism of isothiocyanates against Cochliobolus heterostrophus
Authors: Yu Huilin , Jia Wantong , Zhao Meixi , Li Le , Liu Jinliang , Chen Jingyuan , Pan Hongyu , Zhang Xianghui 
Published: August 2022

AbstractBackgroundIsothiocyanates (ITCs) generated from the ‘glucosinolates‐myrosinase’ defense system in the Brassicaceae exhibit broad antagonistic activity to various fungal pathogens. Nevertheless, the antifungal activity of ITCs to non‐adapted fungi of Brassicaceae plants were seldom determined. The inhibitory effects of ITCs on Cochliobolus heterostrophus were evaluated and the antagonistic mechanism was explored.ResultsThe mycelium growth of C. heterostrophus was hindered significantly by allyl, 4‐(methylthio)‐butyl, and phenyethyl ITCs, 4MTB‐ITC exhibited the highest inhibitory effect on mycelium growth with an IC50 value of 53.4 μmol L−1. In addition, ITCs exhibited obvious inhibitory effect on conidia germination and pathogenicity of C. heterostrophus. Proteomic analysis indicated that the inhibition of C. heterostrophus by A‐ITC downregulated the expression of genes related to energy metabolism, oxidoreductase activity, melanin biosynthesis, and cell wall‐degrading enzymes. Furthermore, mutants ΔChtrx2 and ΔChnox1 showed increased sensitivity to ITCs, and melanin biosynthesis was inhibited significantly in C. heterostrophus in response to A‐ITC. Interestingly, unlike other pathogens that infected Brassicaceae plants, the SaxA in C. heterostrophus displayed no function in ITC degradation. In addition, the ITCs also exhibited obvious inhibitory effect on mycelium growth of Setosphaeria turcica, Fusarium graminearum, and Magnaporthe oryzae.ConclusionThis study indicated that non‐Brassicaceae‐adapted pathogens are more sensitive to ITCs, and ITCs could have applications in protecting non‐Brassicaceae crops in future. In addition, loss of ChNOX1 and ChTRX2 increased the sensitivity of C. heterostrophus to ITCs. Our results provided potential utilization of ITCs to control diseases caused by non‐Brassicaceae pathogenic fungi. © 2022 Society of Chemical Industry.
Deconvolution of overlapping peaks in ion mobility spectrometry based on a multiobjective dynamic teaching‐learning‐based optimization
Authors: Tang Xu , Yu Jiangcheng , Xie Zhijun , Tang Keqi , Hu Shifu , Li Jun , Wu Yong 
Published: August 2022

RationaleBecause of its powerful analytical ability, ion mobility spectrometry (IMS) plays an important role in the field of mass spectrometry. However, one of the main defects of IMS is its low structural resolution, which leads to the phenomenon of peak overlap in the analysis of compounds with similar mass charge ratio.MethodsA multiobjective dynamic teaching‐learning‐based optimization (MDTLBO) method was proposed to separate IMS overlapping peaks. This method prevents local optimization and identifies peak model coefficients efficiently. In addition, the position information of particles largely reflects the half‐peak width of IMS, which makes single peaks difficult to appear and coefficient identification easier.ResultsThe performance comparison of MDTLBO with other deconvolution methods (genetic algorithm, improved particle swarm optimization algorithm, and dynamic inertia weight particle swarm optimization algorithm) shows that the maximum deconvolution error of MDTLBO is only 0.7%, which is much lower than that for the other three methods. In addition, robustness is a performance index that reflects the advantages and disadvantages of the algorithm.ConclusionMBTLBO is more robust than other algorithms for separating overlapping peaks. The algorithm can separate the heavily overlapped mobility peaks, produce better analysis results, and improve the resolution of IMS.
Micro‐punches versus micro‐slices for serial sampling of human dentine: Striking a balance between improved temporal resolution and measuring additional isotope systems
Authors: Cheung Christina , Fernández‐Crespo Teresa , Mion Leïa , Di Giusto Marina , Goude Gwenaëlle , Macdonald Rebecca A. , Richards Michael P. , Herrscher Estelle 
Published: August 2022

RationaleThe last decade has seen a dramatic increase in the application of serial sampling of human dentine in archaeology. Rapid development in the field has provided many improvements in the methodology, in terms of both time resolution as well as the ability to integrate more isotope systems in the analysis. This study provides a comparison of two common sampling approaches, allowing researchers to select the most suitable approach for addressing specific research questions.MethodsTwo common approaches for sequential sampling of human dentine (micro‐punches and micro‐slices) are compared in terms of viability and efficacy. Using archaeological deciduous second molars and permanent first molars, this study demonstrates how the two approaches capture aspects of the weaning process in different ways. In addition, different aspects related to the extraction protocols, such as the thickness of the central slide and the solubilisation step, are also evaluated.ResultsWhile both approaches show similar intra‐tooth isotopic patterns, the micro‐punches approach is preferable for research that requires a very fine temporal resolution, while the micro‐slices approach is best for research where δ34S values are needed, or when the samples are poorly preserved. In addition, the solubilisation step has a large effect on collagen yield, and, to a lesser extent, on isotopic compositions. Therefore, it is important to ensure that only samples that have undergone the same pre‐treatment protocol are directly compared.ConclusionsWe present the pros and cons of the two micro‐sampling approaches and offer possible mitigation strategies to address some of the most important issues related to each approach.
Safety and immunogenicity of Zika virus vaccine: A systematic review of clinical trials
Authors: Yeasmin Mahmuda , Molla Md. Maruf Ahmed , Masud H. M. Abdullah Al , Saif‐Ur‐Rahman K. M. 
Published: August 2022

AbstractSeveral phase‐1 clinical trials have been performed to evaluate the safety and efficacy of candidate anti‐Zika vaccines. In this systematic review, we systematically evaluated the safety and immunogenicity of candidate vaccines, which would aid researchers in formulating an effective vaccination strategy for phase‐2 trials based on current evidence. A literature search was conducted using the electronic databases MEDLINE through Pubmed, Web of Science, and Cochrane Database for relevant studies on candidate anti‐zika vaccines. Studies on animal models were excluded from our study. Healthy individuals who were administered candidate Zika vaccines to evaluate the immune response and adverse events (AEs) compared to placebo were considered. Data were extracted, tabulated, and analysed using Microsoft Excel, while the risk of bias plots were generated using tidyverse and Robvis packages in R‐studio. A total of five phase‐1 clinical trials were included in our analysis comprising of studies on inactivated, viral vector, and DNA vaccines. Immunogenicity ranged from 10% to 100% after vaccination with the lowest seroconversion rate (10%) and geometric mean titre (GMT) (6.3; 95% confidence interval (CI):3.7–10.8) observed among recipients of single‐dose inactivated anti‐zika vaccine (ZPIV). For DNA vaccines, the seroconversion rate ranged from 60% to 100% with the highest seroconversion rate (100%) and GMT (2871; 95% CI:705.3–11688) observed among recipients of three shots of high dose GLS‐5700 vaccine. For viral vector vaccine (Ad26.ZIKV.001) seroconversion rate (100%) and GMT peaked after two shots with both low and high‐dose vaccines. In all those studies AEs were mostly local including injection site pain, erythema, and itching. The most common systemic AEs included fever, myalgia, nausea, and fatigue. In phase‐1 clinical trials, all candidate vaccines were found to be highly immunogenic and relatively safe, especially when administered in higher doses and with the help of needle‐free devices.
Command filter and dynamic surface control technology based adaptive optimal control of uncertain nonlinear systems in strict‐feedback form
Authors: Zhang Tianping , Wang Shixiong , Hua Yu , Xia Meizhen 
Published: August 2022

AbstractIn this article, the problem of command filter and event‐triggered mechanism based adaptive neural optimal control is discussed for a class of nonlinear systems in the presence of unmodeled dynamics in strict‐feedback form. The overall controller design is composed of feedforward controller and feedback controller as well as event‐triggered controller design. In the first part, the feedforward controller is constructed by exploiting command filter and introducing the compensation error, and the first‐order filter in the classical dynamic surface control technology is replaced by utilizing the second‐order filter. In the second part, adaptive dynamic programming algorithm is used to estimate the unknown optimal index function and optimal control signal by the aid of the capability of neural networks. In the third part, based on the feedforward and feedback controllers, an adaptive event‐triggered control is developed to avoid the occurrence of Zeno behavior. All the signals in the controlled system are proved to be semi‐globally uniformly ultimately bounded through theoretical analysis. Two numerical examples are employed to verify the availability of the proposed method.
Low‐carbon tourism for island destinations: A crucial alternative for sustainable development
Authors: Fakfare Pipatpong , Wattanacharoensil Walanchalee 
Published: August 2022

AbstractThe impact of climate change has been evidenced in several tourist destinations, and triggered concerns on the destination development. Low‐carbon tourism has become a national, if not, global agenda that can be used to mitigate the climate change impact caused by the tourist destinations. To respond to this timely agenda and the United Nation World Tourism Organisation's (UNWTO) callout, this study establishes and verifies important components and attributes of low‐Carbon destinations, particularly on island destination, which are still unexamined in the literature. Taking on the perspective of tourists, this study is driven by Stimulus–Organism–Response (S‐O‐R) theory which is a consolidative theoretical framework that integrates environmental input (external), emotional status (internal) and behavioural responses to explain actual behaviours of low‐carbon tourists. Integrated generalised structured component analysis (IGSCA) and multigroup analysis were performed on 1808 travellers who posed different degrees of psychological fear of the COVID‐19 pandemic. During COVID‐19, health and safety risks have become a critical concern; therefore, this study further explores the moderating effect of risk from the perspective of the low‐ and high‐perceived risk travellers, before identifying the attitude‐behaviour gaps of these two groups. The study provides theoretical insights into low‐carbon tourism experience at the island destinations and offers useful managerial implications on low‐carbon destination development.
Synthesis, Antibacterial Evaluation and Molecular Docking Studies of 1,3,4‐Oxadiazole‐2(3H)‐Thione‐Norfloxacin Hybrids as Potent Antibacterial Agents
Authors: Luo Jia‐Bao , Yang Ping , Wang Zi‐Zhou , Zhang Li‐Lei , Zhang Xin‐Guo , Xie Xiao‐Bao 
Published: August 2022

AbstractNovel 1,3,4‐oxadiazole‐2(3H)‐thione‐norfloxacin hybrids were rationally designed based on the pharmacophore hybridization concept and yielded ten potent hybrids. All attained compounds were characterized applying electrospray ionization‐mass spectrometry, nuclear magnetic resonance, and Fourier‐transform infrared spectrophotometry. Compounds 3 c and 3 g were also characterized by single‐crystal X‐ray diffraction techniques. In vitro antibacterial activity of the attained hybrids was evaluated against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. All hybrids exhibited potent antibacterial activity against the test strains with MIC values between ≤0.125 and 1 μg/mL, which were more potent than the parent drug norfloxacin against P. aeruginosa. In particular, compounds 3 a, 3 e, and 3 f were more potent against S. aureus. The hybrid 3 e, with the smallest MIC and MBC against the test strains, showed rapid bactericidal activity in the time‐kill assays and eliminated S. aureus and E. coli <2 h of treatment. Meanwhile, cytotoxicity and hemolysis assays revealed low toxicity of the synthesized hybrids. Molecular docking studies indicated an improved receptor‐hybrid affinity towards DNA topoisomerase IV, showing a least binding energy of −9.4 to −10.0 kcal/mol. Among all the synthesized hybrids, 3 e can be a potential candidate for further antibiotic development.
Copper Hexacyanoferrate Solid‐State Electrolyte Protection Layer on Zn Metal Anode for High‐Performance Aqueous Zinc‐Ion Batteries
Authors: Liu Yu , Li Yuanxia , Huang Xiaomin , Cao Heng , Zheng Qiaoji , Huo Yu , Zhao Jingxin , Lin Dunmin , Xu Bingang 
Published: August 2022

AbstractZinc (Zn) metal possesses broad prospects as an anode for aqueous zinc‐ion batteries (AZIBs) due to its considerable theoretical capacity of 820 mAh g‐1. However, the Zn anode suffers from dendrite growth and side reactions during Zn stripping/plating. Herein, a Prussian blue analog of copper hexacyanoferrate (CuHCF) with a 3D open structure and rich polar groups (CN) is coated on Zn foil as a solid‐state electrolyte (SSE) protection layer to protect the Zn anode. The CuHCF protection layer possesses low activation energy of 26.49 kJ mol‐1, the high ionic conductivity of 7.6 mS cm‐1, and a large Zn2+transference number of 0.74. Hence, the Zn@CuHCF||Zn@CuHCF symmetric cell delivers high cycling stability over 1800 h at 5 mA cm‐2, an excellent depth of discharge of 51.3%, and the accumulative discharge capacity over 3000 mAh cm‐2. In addition, the Zn//Ti@CuHCF asymmetric cell achieves the coulombic efficiency (CE) of 99.87% after 2000 cycles. More importantly, the Zn@CuHCF//V2O5full cell presents outstanding capacity retention of 87.6% at 10 A g‐1after 3000 cycles. This work develops a type of material to form an artificial protection layer for high‐performance AZIBs.
Using simulation modelling and systems science to help contain COVID‐19: A systematic review
Authors: Zhang Weiwei , Liu Shiyong , Osgood Nathaniel , Zhu Hongli , Qian Ying , Jia Peng 
Published: August 2022

AbstractThis study systematically reviews applications of three simulation approaches, that is, system dynamics model (SDM), agent‐based model (ABM) and discrete event simulation (DES), and their hybrids in COVID‐19 research and identifies theoretical and application innovations in public health. Among the 372 eligible papers, 72 focused on COVID‐19 transmission dynamics, 204 evaluated both pharmaceutical and non‐pharmaceutical interventions, 29 focused on the prediction of the pandemic and 67 investigated the impacts of COVID‐19. ABM was used in 275 papers, followed by 54 SDM papers, 32 DES papers and 11 hybrid model papers. Evaluation and design of intervention scenarios are the most widely addressed area accounting for 55% of the four main categories, that is, the transmission of COVID‐19, prediction of the pandemic, evaluation and design of intervention scenarios and societal impact assessment. The complexities in impact evaluation and intervention design demand hybrid simulation models that can simultaneously capture micro and macro aspects of the socio‐economic systems involved.