bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infinite Coordination Polymer Polydopamine Nanocomposites Dual‐Pathway Multistep Induction of Long‐Term Hyperimmunity Combined With Photothermal‐Chemo Synergistic Therapy Colorectal Cancer
Authors: Zhang Xiaojiang , Zhang Yujie , Wang Pengqian , Shi Feiyu , Du Siyuan , Zhang Zhe , Wu Daocheng , She Junjun , Wang Ya 
Published: January 2025

ABSTRACTTo improve the long‐term therapeutic efficacy of colorectal cancer, we propose a synergistic treatment strategy involving dual‐pathway, multistep induction of long‐term hyperimmunity combined with photothermal‐chemotherapy. To implement this strategy, infinite coordination polymer nanoparticles (SN38‐Mn(II)‐EGCG ICP NPs) were prepared by coordinating SN38, EGCG, and Mn2+. These nanoparticles were then coated with polydopamine (PDA) and grafted with folate‐PEG‐thiol (FA‐PEG‐SH) onto their surfaces, producing tumor‐targeting folate‐modified PDA infinite coordination polymer nanocomposites (ICP@FA‐PDA nanocomposites). These nanocomposites exhibit a particle size of 94.9 ± 1.6 nm with a high drug loading capacity (83.3% ± 1.5%), drug release under acidic conditions while maintaining stability in physiological environments. Furthermore, each component within the nanocomposites serves multiple functions. Notably, the incorporation of multiple components triggers a powerful antitumor immune effect and establishes enduring immune memory through a dual‐pathway and multistep approach, which is produced with the activation of the cGAS‐STING pathway and immunogenic cell death (ICD) by a four‐component multistep process. Under a low‐dose regimen, this approach induces dual‐pathway hyperimmunity effect and generates ultra‐long immunological memory, marked by a ninefold increase in CD8+ T cell infiltration, a fourfold increase in CD4+ T lymphocytes, a fourfold reduction in Treg cells, and a fivefold increase in memory T cells. The remarkable therapy efficacy is achieved by hyperimmunity effect combination of SN38 and EGCG chemotherapy and photothermal therapy. In vivo studies demonstrated that mice treated with ICP@FA‐PDA nanocomposites achieved complete eradication of cancer within 21 days, with no recurrence observed within 60 days. These nanocomposites hold significant promise and potential for future clinical translation.
Correlation of the Sinonasal Outcome Test‐22 With the University of Washington Quality of Life in Assessing Quality of Life in Sinonasal Malignancy Utilizing a Multicenter Prospective Observational Cohort Registry
Authors: Fleseriu Cara M. , Wang Eric W. , Beswick Daniel M. , Maoz Sabrina L. , Hwang Peter H. , Kuan Edward C. , Adappa Nithin D. , Geltzeiler Mathew , Abuzeid Waleed M. , Pinheiro‐Neto Carlos D. , Getz Anne E. , Humphries Ian M. , Le Christopher H. , Traylor Katie S. , Chang Eugene H. , Jafari Aria , Kingdom Todd T. , Kohanski Michael A. , Lee Jivianne K. , Nayak Jayakar V. , Palmer James N. , Patel Zara M. , Smith Timothy L. , Snyderman Carl H. , St. John Maie A , Suh Jeffrey D. , Wang Marilene B. , Choby Garret 
Published: January 2025

Key points
In this multi‐center sinonasal malignancies (SNM) cohort, the Sino‐nasal Outcome Test has a correlation with the University of Washington Quality of Life (UWQOL) for assessing QOL.
The use of both instruments remains recommended to provide complete and complementary information.
Future design of an easy‐to‐use tool specific to SNM is needed to encompass all aspects of QOL.
Bidirectional Controlled Quantum State Preparation in High‐Dimensional Quantum System
Authors: Du Si‐Qi , Wei Hai‐Rui 
Published: January 2025

AbstractHigh‐dimensional quantum system exhibits unique advantages over the qubit system in some quantum information processing tasks. A program is presented for implementing deterministic bidirectional controlled remote quantum state preparation (BCRSP) in arbitrary ‐dimensional (quNit) system. By introducing two generalized Greenberger–Horne–Zeilinger (GHZ) states as quantum channels, two communication parties can simultaneously prepare a single‐particle high‐dimensional state at each other's site under the control of Charlie. Compared with the previous counterparts, the significant advantage of our scheme is that the high‐dimensional CNOT operations are not required. Moreover, the performance of this scheme is evaluated. The evaluation of the performance shows that if the quNit is encoded in the spatial mode of single photons, this scheme can be accomplished solely using only linear optical elements.
Structure‐Activity Relationships for s‐Block Metal/Co(III) Heterodinuclear Catalysts in Cyclohexene Oxide Ring‐Opening Copolymerizations
Authors: Butler Frederica , Fiorentini Francesca , Eisenhardt Katharina H. S. , Williams Charlotte K. 
Published: January 2025

AbstractIn homogeneous catalysis, uncovering structure–activity relationships remains very rare but invaluable to understand and rationally improve performances. Here, generalizable structure–activity relationships apply to a series of heterodinuclear polymerization catalysts featuring Co(III) and s‐block metals M(I/II) (M=Na(I), K(I), Ca(II), Sr(II), Ba(II)). These are shown to apply to polycarbonate production by the ring‐opening copolymerizations (ROCOP) of cyclohexene oxide (CHO) and carbon dioxide (CO2), conducted at high (20 bar) and low (1 bar) CO2 pressures, and to polyester production by copolymerization of cyclohexene oxide and phthalic anhydride (PA). For the CHO/PA and high‐pressure CHO/CO2 copolymerizations, activity increases exponentially with s‐block metal acidity peaking at the Co(III)K(I) catalyst, whilst for the low‐pressure CHO/CO2 copolymerization it increases linearly to the same metal combination. The polymerization kinetics fit second order rate laws and the correlations support dinuclear metallate mechanistic hypotheses. These relationships help understand and identify key metal complex structural features in synergic polymerization catalysis.
Solvent‐Free Preparation of Reactive Flame‐Retardant Polyurethane Resin for Synthetic Leather Applications
Authors: Zhao Jinbiao , Duan Huimin , Yang Hao , Huang Zhichao , Qi Dongming 
Published: January 2025

ABSTRACTIn order to reduce the high pollution and flammability of polyurethane in high‐performance automotive synthetic leather, the development of a solvent‐free flame‐retardant reactive polyurethane (RPU) coating material has become a research focus. However, solvent‐free environments not only place higher requirements on the fluidity and processability of materials but also present significant technical challenges in achieving a balance between strength and flame retardancy. In this paper, inorganic ionic polymer particle ammonium polyphosphate (APP) was used as filler and reactive polyurethane resin as a carrier to prepare a flame‐retardant modified polyurethane composite membrane with a foaming structure through a two‐step method. The results showed that adding 4% APP could extend the molding time of reactive polyurethane to 550 s—an increase by about 53%—and increase its mechanical strength to 23.01 MPa. Thermal analysis verified that the cross‐linking degree of reactive polyurethane resin was increased due to APP, and its thermal stability could be effectively improved. The reactive polyurethane modified with 4% APP had a residual carbon content exceeding 12% after heat treatment, and its limiting oxygen index can reach 23.7%. Additionally, the peak value of heat release rate (PHRR) was reduced by 10.7% and total heat release rate (THR) by 25.1%, enhancing the flame retardant effect. This method was of great significance to the production of polyurethane for automotive leather.
Differences in motivation for biology learning: A measurement invariance testing and latent mean comparison approach
Authors: Dai Ting , Xing Kuan , Kaplan Avi , Cromley Jennifer G. , Mara Kyle R. , Perez Tony 
Published: January 2025

AbstractEducational and psychological research often involves comparing motivation across groups. It is critical to ensure that observed differences in motivation are true variations by group, not due to measurement biases. With a diverse sample of undergraduate students (N = 2200), this study measured internal consistency and gathered validity evidence based on the internal structure of five motivation scales. To compare motivation for biology between groups of undergraduate students, this study tested for measurement scalar invariance by group and, accordingly, conducted latent factor mean comparisons to understand true group differences. On average, female students held lower expectancy beliefs and self‐efficacy for biology learning than males. Female students perceived higher attainment value and utility value for biology learning and higher psychological cost. First‐generation college students held lower expectancy beliefs and self‐efficacy but perceived higher attainment value for biology learning than continuing‐generation students. No differences in average motivation for biology learning were found between underrepresented racial minority (URM) and non‐URM students. The implications of these findings and future research directions are also discussed.
Distributed control for automated vehicle groups using control barrier and control Lyapunov functions
Authors: Hayashi Yuzuki , Cao Wenjing , Mukai Masakazu 
Published: January 2025

AbstractWith the increasing demands for courier services, economic losses and environmental problems resulting from driver shortages, traffic accidents, and congestion continue to plague the logistics industry. Consequently, many studies of platooning exist to solve the above problems. This paper presents a procedure for the composition of automated vehicle groups required for platooning in real‐world vehicle control. In particular, adaptive cruise control is considered, and each automated vehicle is equipped with velocity, intervehicular distance, relative velocity, and slope monitoring sensors. Distributed control is performed using the controllers installed on each vehicle. The adopted control method uses quadratic programming with a control barrier function and a control Lyapunov function formulated as constraints. On solving the optimization problem, we discover that the driving forces can be optimized, and a group of vehicles maintaining a constant convergence intervehicular distance can be configured using mathematical equations and simulations.
Asymptotic stability of fractional order switching nonlinear system based on short memory principle
Authors: Mu Qianqian , Long Fei , Wang Qixiang 
Published: January 2025

AbstractFractional order derivatives have memory effects and are widely used in real world applications. However, they require large storage space and lead to low computational efficiency. Therefore, fractional order systems based on the short memory principle have gradually attracted the scholars' attention. In this paper, the asymptotic stability of Caputo fractional order switching nonlinear systems is investigated based on the Markov process and short memory principle. Firstly, a model of Caputo fractional order Markovian switching nonlinear systems (CFMNSs) based on the short memory principle is constructed so that the lower bound initial time and the corresponding initial state values are updated synchronously with switching. Secondly, the stability of the system is investigated based on the probabilistic analysis method and stochastic multi‐Lyapunov functions and the sufficient conditions for the asymptotic stability of the system are given. Using a similar method, we also study the asymptotic stability of CFMNs with variable fractional order. Finally, the simulation results show that the proposed stability scheme is effective and reasonable.
Made With Love: Examining Consumer Engagement With Handmade Versus Machine‐Made Production Cues
Authors: Degirmenci Tuba , Mathmann Frank , Mortimer Gary 
Published: January 2025

ABSTRACTAdvancing technologies have led to structural change in production methods, influencing not only business practices but also significantly reshaping consumer mindsets. Businesses increasingly utilise production cues, such as ‘handmade’, to differentiate their products and foster consumer engagement. While prior studies demonstrate that production cues can affect consumer responses, it remains unclear how the impact of these cues (e.g., handmade vs. machine‐made) differs between consumer segments. Marketers remain uncertain about how to strategically leverage these effects across consumer profiles and product portfolios. Addressing this gap, this research applies regulatory mode theory, providing a nuanced understanding of production cues' impact on consumer engagement, with a focus on locomotion regulatory mode. Study 1, an online survey experiment, presents a moderated mediation analysis: while the effect of production cues on willingness to pay is mediated through love, this impact significantly varies with consumers' locomotion regulatory mode (low vs. high). Study 2 extends these findings through an automated text analysis of social media data (n = 9380), validating the moderating role of locomotion in a real‐world context by analysing the marketer‐generated content of Facebook posts. The findings of both studies confirm our predictions that production cues elicit distinct engagement responses depending on consumer segments: high‐locomotion consumers, who value efficiency, show diminished engagement with production cues. This research advances the theory of production cue effects by offering novel insights and provides marketers with actionable implications for segmentation and targeted communication.
Circadian clock gene BMAL1 is involved in transforming growth factor β1‐induced fibrotic response in NRK‐49F cells
Authors: Takaguri Akira , Noro Ryuta , Shinohe Sari , Murayama Reina , Sakuraba Mei , Nomura Reo , Satoh Kumi 
Published: January 2025

AbstractThe transcription factor brain and muscle Arnt‐like protein‐1 (BMAL1) is a clock protein involved in various diseases, including atherosclerosis and cancer. However, BMAL1's involvement in kidney fibrosis and the underlying mechanisms remain largely unknown, a gap addressed in this study. Analysis through Masson's trichrome and Sirius red staining revealed that all groups exposed to unilateral ureteral obstruction showed increased BMAL1 protein expression accompanied by increased TGF‐β1 expression and elevated key fibrosis markers, including α‐SMA, compared with sham groups. Although TGF‐β1 induced BMAL1 protein expression accompanied by increased α‐SMA expression in NRK‐49F cells, the REV‐ERBα agonist GSK4112, a transcriptional repressor of BMAL1, or siRNA targeting BMAL1 significantly inhibited TGF‐β1‐induced α‐SMA expression. Furthermore, BMAL1 knockdown significantly suppressed TGF‐β1‐induced NOX4/ROS/p38 pathways in NRK‐49F cells. Thus, BMAL1 positively regulates TGF‐β1‐induced signaling associated with fibrotic responses via the NOX4/ROS/p38 pathway. Overall, this study uncovers BMAL1 as a promising therapeutic target for preventing and treating kidney fibrosis, potentially preventing renal failure.
Paclitaxel‐Coated Balloon for the Management of In‐Stent Coronary Restenosis: An Updated Meta‐Analysis and Trial Sequential Analysis
Authors: Oliveira Vinícius M. R. , Paiva Arthur Marot , Alencar Pedro Lucas Alves , Oliveira Izadora Caiado , Alencar João Victor Alves , Zalaf Felipe Schmaltz , Piai Ricardo Figueiredo Paro , de Sousa André Maroccolo , Moreira Humberto Graner 
Published: January 2025

ABSTRACTBackgroundDrug‐coated balloons present a potentially advantageous therapeutic approach for managing coronary in‐stent restenosis (ISR). However, the comparative benefits of paclitaxel‐coated balloons (PCBs) over uncoated balloons (UCBs) remain unclear.AimsWe conducted a systematic review and meta‐analysis to evaluate and compare the clinical outcomes of patients treated with PCBs and UCBs.MethodsWe systematically searched PubMed, Embase, and Cochrane for studies comparing PCBs and UCBs in managing coronary ISR. We used a random‐effects model to pool risk ratios (RRs) and their 95% confidence intervals (CIs). Statistical analyses were conducted using Review Manager 5.4.1. Heterogeneity was assessed using I2 statistics. Quality and risk of bias were evaluated using the Cochrane Collaboration's tool.ResultsWe included seven randomized controlled trials with 1349 patients, of whom 840 underwent percutaneous coronary intervention with PCB. In our pooled analysis, patients treated with PCB had lower risks of target lesion revascularization (RR 0.31, 95% CI 0.18–0.52; p < 0.01), target vessel revascularization (0.53, 0.42–0.67; p < 0.01), major adverse cardiac events (MACEs) (0.25, 0.16–0.38; p < 0.01), and myocardial infarction (MI) (0.59, 0.37–0.95; p = 0.03). However, there were no significant differences in all‐cause mortality (0.79, 0.37–1.70; p = 0.54), cardiac death (0.46, 0.03–8.12; p = 0.60), while tendencies for a significant difference were found for target lesion failure (0.39, 0.13–1.11; p = 0.08), or stent thrombosis (0.21, 0.03–1.35 p = 0.10).ConclusionThese findings suggest that PCBs are superior to UCBs regarding the occurrence of target lesion revascularization, target vessel revascularization, MACEs, and MI, but they do not differ in all‐cause mortality, and cardiac death, while trends to significant differences favoring PCB were found to stent thrombosis and target lesion failure.
Valve Thrombosis Following Transcatheter Aortic Valve Replacement: State‐of‐the‐Art Review
Authors: Duarte Fabiana , Aguiar‐Neves Inês , Guerreiro Cláudio Espada , Silva Mariana , Ferreira Nuno D. , Fontes‐Carvalho Ricardo 
Published: January 2025

ABSTRACTTranscatheter aortic valve replacement (TAVR) is a well‐established treatment for severe aortic stenosis, especially in patients over 75 or those at high surgical risk. While these prosthetic valves have a lower thrombogenic profile than mechanical heart valves, leaflet thrombosis in transcatheter aortic valves (TAV) occurs in an estimated 5%–40% of cases. Most TAV thromboses are subclinical and can be detected via cardiac computed tomography (CCT), which reveals hypo‐attenuating leaflet thickening and reduced leaflet motion in asymptomatic patients without elevated transprosthetic gradients on echocardiography. The mechanisms behind TAV thrombosis involve local mechanical triggers, patient predisposing factors, and device and procedure‐related aspects. The ideal antithrombotic therapy post‐TAVR depends on individual patient characteristics, balancing bleeding risks with the need for oral anticoagulants. Data on the optimal management of TAV thrombosis and the routine use of CT post‐TAVR are limited. While anticoagulation effectively resolves clinically significant prosthesis thrombosis, its benefit in subclinical cases is unclear. There is an ongoing debate about whether subclinical leaflet thrombosis precedes clinical valve thrombosis, making the ideal follow‐up after valve implantation uncertain. This article aims to provide a comprehensive review, summarizing current data on the incidence of TAVR thrombosis, underlying mechanisms, clinical and imaging diagnosis, management strategies, preventive measures, and long‐term follow‐up.
The Impact of Cardiac Damage on In‐Hospital Outcomes for Patients With Aortic Stenosis in the United States: An Analysis From The National Inpatient Sample
Authors: Kwok Chun Shing , Bennett Sadie , Joshi Mithilesh , Qureshi Adnan I. , Elsayed Khaled , Appaji Anikethana , Holroyd Eric , Pibarot Philippe , Redfors Bjorn , Genereux Philippe 
Published: January 2025

ABSTRACTIntroductionThe objective of this study is to determine if cardiac damage based on hospital discharge codes is associated with in‐hospital outcomes in patients with aortic stenosis (AS).MethodsWe conducted a retrospective cohort study of hospital admissions between 2016 and 2021 with a diagnosis of AS in the National Inpatient Sample (NIS). The cardiac damage stages 0−4 were determined based on hospital discharge codes. Logistic and linear regressions were used to determine the association between cardiac stage and in‐hospital mortality, length of stay (LoS) and cost.ResultsA total of 2,980,150 hospital admissions were included in the analysis (82.5% conservative management, 11.2% transcatheter aortic valve replacement [TAVR], 6.3% surgical aortic valve replacement [SAVR]). The association between cardiac damage stage and in‐hospital outcome was most significant for patients who had SAVR treatment (stage 4 vs. stage 0: mortality OR 27.70 95% CI 17.35−35.17, LoS 7.34 95% CI 6.34−8.35, cost 70,710 95% CI 65,110−76,310) compared to TAVR treatment (stage 4 vs. stage 0: mortality OR 9.15 95% CI 5.52−15.15, LoS 6.27 95% CI 5.63−6.90, cost 28,384 25,084 to 31,684) and conservative treatment (stage 4 vs. stage 0: mortality OR 3.55 95% CI 3.13−4.04, LoS 2.09 95% CI 1.87 to 2.31, cost 6362 95% CI 5642−7083).ConclusionsCardiac damage can be evaluated using diagnostic codes in patients with AS and it is associated with in‐hospital mortality, LoS and cost, and has more impact on these outcomes in patients treated with SAVR versus those treated with TAVR.
The effect of main component interactions on the rheological and pasting properties of naked oat flour during Sanshu thermal processing of oat‐based food
Authors: Peng Pai , Rafique Hamad , Wang Xiaolong , Dong Rui , Zou Liang , Hu Xinzhong 
Published: January 2025

AbstractBackground and ObjectivesThe molecular interactions in naked oat flour are crucial to its processing quality. To investigate interaction mechanisms during oat‐food Sanshu thermal processing, this study analyzed starch structure properties, rheological properties, and interactions between starch and other components in naked oat flour.FindingsThe rheological and pasting properties of oat starch were closely related to its structure during different thermal stages. X‐ray diffraction revealed the formation of amylose–lipid complexes, and the starch–lipid/starch–protein interactions were confirmed by specific functional groups from Fourier transform infrared spectra. The formation of complexes during roasting thermal treatment significantly increased G′ and G″, while the decomposition of starch during boiling and steaming thermal treatment reduced the rheological properties. SEM showed the dispersion and decomposition of starch, which further provided evidence for the interaction of starch and other components during Sanshu processing. The digestibility increased gradually, as the starch gelatinized during Sanshu processing. During steaming thermal treatment, RDS did not change significantly, while SDS transformed into RS (RS content increased to 9.36%).ConclusionsThe interaction of starch–lipids/starch–protein occurred during oat‐food Sanshu thermal processing. The alterations in the rheological and pasting properties of naked oat flour were observed to be intimately linked to these complexes.Significance and NoveltyThe structure of naked oat flour is closely related to its processing quality. The observed changes in starch short‐range order and the formation of a microcrystalline structure are closely related to RS, which can be used as a signal of interaction‐resistant starch formation.