bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantifying the changes in the tumour vascular micro-environment in spinal metastases treated with stereotactic body radiotherapy - a single arm prospective study
Authors: Vellayappan Balamurugan , Cheong Dennis , Singbal Salil , Tey Jeremy , Yang Soon Yu , Nang Leong Cheng , Wong Alvin , Lwin Sein , Hung Lee Chau , Periasamy Pravin , Lo Simon , Kumar Naresh 
Published: December 2022

Abstract

Background
The primary objective was to quantify changes in vascular micro-environment in spinal metastases (SM) patients treated with stereotactic body radiotherapy (SBRT) with multi-parametric dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI). The secondary objective was to study plasma biomarkers related to endothelial apoptosis.

Patients and methods
Patients were imaged with DCE-MRI at baseline/1-week/12-weeks post-SBRT. Metrics including normalised time-dependent leakage (Ktrans), permeability surface product (PS), fractional plasma volume (Vp), extracellular volume (Ve) and perfusion (F) were estimated using distributed parameter model. Serum acid sphingomyelinase (ASM) and sphingosine-1-phosphate (S1P) were quantified using ELISA. Clinical outcomes including physician-scored and patient-reported toxicity were collected.

Results
Twelve patients (with varying primary histology) were recruited, of whom 10 underwent SBRT. Nine patients (with 10 lesions) completed all 3 imaging assessment timepoints. One patient died due to pneumonia (unrelated) before follow-up scans were performed. Median SBRT dose was 27 Gy (range: 24–27) over 3 fractions (range: 2–3). Median follow-up for alive patients was 42-months (range: 22.3–54.3), with local control rate of 90% and one grade 2 or higher toxicity (vertebral compression fracture). In general, we found an overall trend of reduction at 12-weeks in all parameters (Ktrans/PS/Vp/Ve/F). Ktrans and PS showed a reduction as early as 1-week. Ve/Vp/F exhibited a slight rise 1-week post-SBRT before reducing below the baseline value. There were no significant changes, post-SBRT, in plasma biomarkers (ASM/S1P).

Conclusions
Tumour vascular micro-environment (measured by various metrics) showed a general trend towards downregulation post-SBRT. It is likely that vascular-mediated cell killing contributes to excellent local control rates seen with SBRT. Future studies should evaluate the effect of SBRT on primary-specific spinal metastases (e.g., renal cell carcinoma).
Dose-escalated radiotherapy with simultaneous integrated boost for bone metastases in selected patients with assumed favourable prognosis
Authors: Potkrajcic Vlatko , Mueller Arndt-Christian , Frey Bettina , Gani Cihan , Zips Daniel , Hoffmann Ruediger , Frantz Sandra , Warm Verena , Paulsen Frank , Eckert Franziska 
Published: December 2022

Abstract

Background
Stereotactic body radiotherapy (SBRT) concepts for dose escalation are increasingly used for bone metastases in patients with oligometastatic or oligoprogressive disease. For metastases that are not suitable for SBRT-regimens, a treatment with 30/40 Gy with simultaneous integrated boost (SIB) in 10 fractions represents a possible regimen. The aim of this study was to investigate the feasibility of this concept and the acute and subacute toxicities.

Patients and methods
Clinical records for dose-escalated radiotherapy of all consecutive patients treated with this regimen were evaluated retrospectively (24 patients with 28 target volumes for oncologic outcomes and 25 patients with 29 target volumes for treatment feasibility and dose parameters analysis). Analysis of radiotherapy plans included size of target volumes and dosimetric parameter for target volumes and organs at risk (OAR). Acute and subacute toxicities were evaluated according to Common Terminology Criteria for Adverse Events (CTCAE) V4.0.

Results
The most common localization was the spine (71.4%). The most common histology was prostate cancer (45.8%). Oligometastatic or oligoprogressive disease was the indication for dose-escalated radiotherapy in 19/24 patients (79.2%). Treatment was feasible with all patients completing radiotherapy. Acute toxicity grade 1 was documented in 36.0% of the patients. During follow up, one patient underwent surgery due to bone instability. The 1-year local control and patient-related progression-free survival (PFS) were 90.0 ± 6.7% and 33.3 ± 11.6%, respectively.

Conclusions
Dose-escalated hypofractionated radiotherapy with simultaneous integrated boost for bone metastases resulted in good local control with limited acute toxicities. Only one patient required surgical intervention. The regimen represents an alternative to SBRT in selected patients.
Citrullus colocynthis (L.) Schrad (Bitter Apple): An Overview of its Traditional Uses, Phytochemistry and Pharmacological Potential
Authors: Kamboj Anil , Dahiya Randhir Singh 
Published: December 2022

Abstract
Citrullus colocynthis (L.) Schrad is an important cucurbit plant, commonly distributed in the sandy areas of the world. In the Indian continent it is mainly found in the North West, the Punjab and in Central and southern India. The Citrullus colocynthis plant is usually known for its traditional uses as a remedy in the treatment of asthma, diabetes, common cold, leprosy, cough, bronchitis, joint pain, jaundice, cancer, toothache, mastitis, and in gastrointestinal disorders such as gastroenteritis, indigestion, dysentery, constipation, colic pain and other microbial infections. Phytochemicaly the compounds like glycosides, alkaloids, flavonoids, phenolic acids fatty acids, carbohydrates and essential oils were reported from the plant and the main components isolated from the Citrullus colocynthis plant are Cucurbitacins. The plant has been studied extensively for its wide range of pharmacological activities, which include anticancer, antidiabetic, antioxidant, cytotoxic, antimicrobial, anti-inflammatory antilipidemic, and insecticide but the therapeutic potential for cardiovascular, gut, airways and many other diseases remain to be explored.
Non-Archimedean Koksma Inequalities, Variation, and Fourier Analysis
Authors: Petsche Clayton , Somasunderam Naveen 
Published: December 2022

Abstract
We examine four different notions of variation for real-valued functions defined on the compact ring of integers of a non-Archimedean local field, with an emphasis on regularity properties of functions with finite variation, and on establishing non-Archimedean Koksma inequalities. The first version of variation is due to Taibleson, the second due to Beer, and the remaining two are new. Taibleson variation is the simplest of these, but it is a coarse measure of irregularity and it does not admit a Koksma inequality. Beer variation can be used to prove a Koksma inequality, but it is order-dependent and not translation invariant. We define a new version of variation which may be interpreted as the graph-theoretic variation when a function is naturally extended to a certain subtree of the Berkovich affine line. This variation is order-free and translation invariant, and it admits a Koksma inequality which, for a certain natural family of examples, is always sharper than Beer’s. Finally, we define a Fourier-analytic variation and a corresponding Koksma inequality which is sometimes sharper than the Berkovich-analytic inequality.
Performance Differences between ESG Indices and Conventional Market Indices: a Multivariate Analysis of Indices
Authors: Kurnoga Nataša , Šimurina Nika , Fučkan Filip 
Published: December 2022

Abstract
This paper aims to identify performance differences between conventional European equity indices and ESG indices. Conventional European equity indices are tools both institutional and retail investors use to understand the overall state of the market, as well as a benchmark for comparing investment decisions. ESG indices or sustainability indices are different from conventional market indices and can provide information to investors about the firm’s sustainability performance, they are new and constantly developing stock market indices taking into account environmental, social, and governance considerations. The indices were analysed by multivariate analysis. Since we could collect data by country only for conventional indices, cluster analysis based only on those indices was performed. The following variables of conventional indices were analysed: year-to-date price return, annualized 3-year price return, annualized 5-year price return, and annualized 10-year price return. The paper also compares ESG indices and conventional indices, and in most cases, they have no significant performance differences.
Analisis Keamanan Aplikasi Android Dengan Metode Vulnerability Assessment
Authors: Ardita I Kadek Aldy Oka , Anom Cahyadi Putra I Gusti Ngurah , Kustiadie Mohammad Rizky , Dika Varuna Gusti Ngurah Made , Eka Prananda Made Yayang 
Published: December 2022

Seiring berkembangnya beragam aplikasi maka sistem Android haruslah tahan terhadap bebagai serangan malware dengan mengamati izin akses yang diberikan oleh pengguna. Penyerang dapat menggunakan kerentanan dalam aplikasi untuk mencuri berbagai informasi penting. Informasi merupakan aset penting dan berharga berupa rekaman suara, rekaman video, catatan, dll. Oleh karena itu, diperlukan suatu analisis keamanan. dari aplikasi yang digunakan dengan tes / tindakan pada tingkat keamanan aplikasi. Dalam melakukan Vulnerability test atau proses identifikasi celah keamanan pada aplikasi android dilakukan dua teknik yaitu dengan MobSF dan dengan frida. Hasil dari Analisis MobSF sangat terlihat perbedaannya antara mendownload aplikasi melalui pihak ketiga dengan mendownload aplikasi melalui Play Store. Dimana nilai hash yang didapat sangat berbeda baik dari md5, sha1, atau sha256, dari hasil tersebut dapat diketahui bahwa ada perubahan pada file yang disediakan oleh penyedia pihak ketiga. Pada security score didapatkan bahwa aplikasi yang di download melalui pihak ketiga terdapat banyak server dan aktivitas mencurigakan, sedangkan aplikasi yang terdapat di playstore terdapat 2 server yang asli. Pada size, ukuran file yang disediakan oleh pihak ketiga, ukuran file asli hanya 20.37MB sedangkan file yang di sediakan oleh pihak ketiga berukuran 61.33MB. Pada analisis menggunakan frida dilakukan proses penyerangan yaitu bypass login. Dimana pada aplikasi pihak ketiga sudah memiliki email yang telah diinputkan oleh penyedia aplikasi.
Dari hasil analisis yang dilakukan maka lebih baik untuk mendownload aplikasi melalui playstore agar lebih aman. Karena sebagai pengguna awam tidak akan tahu perubahan file apa yang dilakukan dan beresiko atau tidaknya perubahan tersebut terhadap perangkat tersebut
HỌC TIẾNG ANH DI ĐỘNG: THANH THIẾU NIÊN VIỆT NAM ĐÃ TỰ CHỦ HỌC CHƯA?
Authors: Phạm Ngọc Thạch , Nguyễn Hoàng Dương , Đặng Đình Quân , Hoàng Quý , Nguyễn Xuân Thắng , Trần Minh Thành , Đinh Thị Hải 
Published: December 2022

Bài viết trình bày kết quả thử nghiệm một ứng dụng học tiếng Anh di động có tên

M-learning với hơn 300 người học là học sinh phổ thông và sinh viên đại học. Sử dụng phương pháp thống kê mô tả và suy diễn để phân tích dữ liệu thu được từ hai đợt thử nghiệm ứng dụng, nghiên cứu cho thấy có sự khác biệt rất lớn về mức độ tham gia và hoàn thành các bài luyện có trong ứng dụng và tính tự chủ của đối tượng tham gia thử nghiệm còn hạn chế. Tuy nhiên, kết quả phân tích dữ liệu cho thấy có mối tương quan giữa số lần đăng nhập vào ứng dụng, hoàn thành bài luyện, hoàn thành câu hỏi, thời gian học và kết quả làm bài luyện. Nghiên cứu có ý nghĩa thực tế trong việc xây dựng và thử nghiệm ứng dụng di động học tiếng Anh cho thanh thiếu niên Việt Nam, đặc biệt là tầm quan trọng của việc hình thành, nuôi dưỡng và duy trì tính tự chủ của nhóm người học này.
Bayesian approach to the tomographic problem with constraints from geodynamic modeling: Application to a synthetic subduction zone
Authors: Magali John Keith , Bodin Thomas 
Published: December 2022

Geodynamic tomography, an imaging technique that incorporates constraints from geodynamics and mineral physics to restrict the potential number of candidate seismic models down to a subset consistent with geodynamic predictions, is applied to a thermal subduction model. The goal is to test the ability of geodynamic tomography to recover structures harbouring complex deformation patterns. The subduction zone is parameterised in terms of four unknown parameters namely the slab length L, thickness R, temperature Tc, and dip angle θ that define its thermal structure. A temperature-dependent viscosity is then prescribed with an activation coefficient E controlling the sensitivity. Using the full forward approach to geodynamic tomography, we generate anisotropic surface wave dispersion measurements as synthetic data. We then attempt to retrieve the five unknown parameters by inverting the synthetics corrupted with random uncorrelated noise. The final output is an ensemble of models of L, R, θ, Tc and E cast in terms of a posterior probability distribution and their uncertainty limits. Results show that the parameters are tightly constrained with the apparent existence of a single misfit minima in each of them, which implies the implicit retrieval of the complete patterns of upper mantle deformation, and correspondingly, the 21-independent coefficients defining elastic anisotropy. Each model realisation however fails to swarm around its true value. Such results are attributed to the inability of the surrogate model to accurately replicate the correct forward model for computing anisotropy due to the inherent complexity of the deformation patterns considered. Nevertheless, this proof of concept shows a self-consistent method that incorporates mantle flow modeling in a seismic inversion scheme.
PENYELESAIAN PEMBIAYAAN MACET DENGAN JAMINAN HAK TANGGUNGAN DI KOPERASI SIMPAN PINJAM DAN PEMBIAYAAN SYARIAH (KSPPS) HUDATAMA CABANG SEMARANG BARAT
Authors: Nugroho Ari , Astanti Dhian Indah , Septiandani Dian 
Published: December 2022

<p>Koperasi Simpan Pinjam dan Pembiayaan Syariah (KSPPS) diatur dalam Peraturan Menteri Koperasi dan Usaha Kecil dan Menengah Republik Indonesia Nomor 11 Tahun 2017 tentang Pelaksanaan Kegiatan Usaha Simpan Pinjam dan Pembiayaan Syariah oleh Koperasi. Salah satu kegiatan usahanya yaitu penyaluran pembiayaan. Pembiayaan yang diberikan oleh pihak KSPPS kepada debitur berdasarkan perjanjian baik perjanjian pokok maupun perjanjian tambahan berupa pemberian jaminan oleh debitur kepada kreditur disertai pemberian bagi hasil dengan jangka waktu pengembalian yang sudah ditentukan. Dalam penelitian ini membahas terkait penyelesaian pembiayaan macet dengan jaminan hak tanggungan, kendala dalam penyelesaian pembiayaan macet dan upaya mengatasinya. Jenis penelitian ini adalah yuridis empiris, spesifikasi penelitian deskriptif analitis, data yang dipergunakan yaitu data primer didukung data sekunder dengan analisa data kualitatif. Hasil penelitian menunjukkan penyelesaian pembiayaan macet dengan jaminan hak tanggungan, sebagai sumber pelunasan sudah sesuai dengan peraturan yang berlaku yaitu <em>parate eksekusi </em>dan <em>title eksekutorial </em>namun KSPPS Hudatama perlu memaksimalkan upaya penyelesaian penjualan bawah tangan sebagai upaya alternatif. Penyelesaian pembiayaan macet terdapat kendala yang dihadapi yaitu kendala interal dan eksternal, kendala dari internal yaitu kurang telitinya analis is pembiyaan dan upaya mengatasinya manajemen dapat melakukan pelatihan berkaitan dengan analisis pembiyaan, kendala eksternal yaitu anggota tidak kooperatif, upaya mengatasinya dengan memperhatikan peraturan yang berlaku.</p>
IMPLEMENTASI UNDANG-UNDANG PERLINDUNGAN KONSUMEN TERHADAP PENUMPANG JASA TRANSPORTASI PT.KAI DAERAH OPERASI 4 SEMARANG
Authors: Kurniawan Denata , Heryanti Rini , Triasih Dharu 
Published: December 2022

<p>Kereta api merupakan salah satu alat transportasi darat yang paling diminati karena menghemat waktu dan menghemat uang. Dalam tugasnya memberikan pelayanan kepada konsumen, tentunya PT. KAI sebagai penyelenggara harus memperhatikan dan melindungi hak-hak konsumen agar dapat terselenggaranya pelayanan yang terbaik dan tidak merugikan konsumen. Pada penelitian kali ini, penulis akan menganalisis Undang-Undang Perlindungan Konsumen Terhadap Penumpang Jasa Transportasi PT. KAI Daerah Operasi 4 Semarang. Dengan perumusan masalah yang akan dibahas yaitu produk hukum perlindungan konsumen yang diimplementasikan dalam pelayanan jasa transportasi kereta api, bentuk tanggung jawab penyedia jasa kereta api (PT.KAI) bila terjadi kerugian yang dialami penumpang dan upaya yang ditempuh penumpang jasa transportasi kereta api apabila tidak dipenuhi haknya sebagai konsumen yang ditinjau dengan UU Perlindungan Konsumen. Penelitian kali ini termasuk kedalam penelitian yuridis sosiologis dengan spesifikasi penelitian deskriptif analitis, penulis juga menggunakan teknik non random dalam <em>purposive sampling </em>kemudian dianalisa dengan analisa kualitatif. Hasil penelitian yang dilakukan yaitu produk hukum terdapat dalam Undang-Undang Nomor 8 Tahun 1999 tentang Perlindungan Konsumen dan Undang-Undang Nomor 23 Tahun 2007 tentang Perkeretaapian. Selain produk hukum, tanggung jawab penyelenggara sarana dan prasarana perkeretaapian yaitu dengan standar pelayanan minimum penumpang baik di stasiun maupun di dalam perjalanan kereta api mencakup keselamatan, keamanan, kehandalan, kenyamanan, kemudahan dan kesetaraan dan dalam mengatasi keluhan dan ketidaknyamanan penumpang dalam hal pelayanan yang diberikan, baik itu dalam masalah sarana dan prasarana perkeretaapian. Pengguna jasa juga dapat melakukan upaya agar pemenuhan hak-haknya dapat didapatkan sesuai peraturan yang berlaku dengan cara menempuh jalur hukum melalui pengadilan atau non pengadilan.</p>
Implementasi Mesin Peras Santan Tipe Screw Guna Meningkatkan produktivitas Minyak Kelapa Di IKM-Al Iffah
Authors: Muanah Muanah , Yanti Sandra Dewi Novi , Ghazali Mursal , Azhari  , Kusuma Wardi Hasri , Nurhayati Nurhayati 
Published: December 2022

Pemerasan Santan merupakan salah satu elemen kerja dalam pembuatan minyak kelapa. Proses pemerasan santan ini membutuhkan waktu dan kebutuhan kerja yang banyak sehingga diperlukan impelementasi mesin untuk efisiensi waktu dan tenaga kerja serta peningkatan produksi minyak kelapa. Tujuan kegiatan ini adalah untuk meningkatkan pengetahuan dan keterampilan serta produktivitas minyak kelapa yang dihasilkan. Metode pengabdian ada dua yaitu penyuluhan dan pelatihan. Penyuluhan untuk mengenalkan kepada mitra secara teori dan juga sebagai bekal untuk melakukan pelatihan. Sedangkan pelatihan dilakukan untuk belajar mengoperasikan mesin secara langsung. Berdasarkan hasil dan pembahasan menunjukkan bahwa kegiatan pendampingan mampu meningkatkan pengetahuan Mitra IKM-Al Iffah sebesar 75%, keberadaan mesin ini juga mampu meningkatkan 80% efisiensi tenaga kerja dan efisiensi waktu serta meningkatnya jumlah produksi minyak kelapa yang dihasilkan
Problem Focused Coping Pada Mahasiswa Yang Sedang Mengerjakan Skripsi: Apakah Terkait dengan Efikasi Diri Akademik?
Authors: El Roy Belga Grace , Soetjiningsih Christiana Hari 
Published: December 2022

The purpose of this study was to determine the relationship between academic self-efficacy and coping with stress, which focused on the problem of students working on their thesis. This research is quantitative research with a correlational design. Participants accepted 52 students who are working on a thesis at the SWCU Psychology Faculty. Data analysis using Pearson's product-moment correlation technique shows a value of r = 0.831 and a significance value of 0.000 (p≤0.05), which means that there is a positive relationship between academic self-efficacy and problem-focused coping in students who are working on their thesis. The higher the academic self-efficacy of students who are working on their thesis, the higher/better the problem-focused coping, and vice versa.Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara academic self-efficacy dengan coping stress yang berfokus pada masalah (Problem Focused Coping) pada mahasiswa yang sedang mengerjakan skripsi. Penelitian ini merupakan penelitian kuantitatif dengan desain korelasional. Partisipan berjumlah 52. mahasiswa yang sedang mengerjakan skripsi di Fakultas Psikologi UKSW. Analisis data dengan teknik korelasi product moment dari Pearson menunjukkan nilai r = 0,831 dan nilai signifikansi sebesar 0,000 (p≤0,05). Hasil hipotesis menunjukan terdapat hubungan positif antara Academic self-efficacy dengan problem focused coping pada mahasiswa yang sedang mengerjakan skripsi. Sehingga makin tinggi self-efficacy akademik mahasiswa yang sedang mengerjakan skripsi maka makin tinggi/baik problem focused coping nya, dan sebaliknya
Frequency and nature of thyroid pathology in children and adolescents with type 1 diabetes mellitus and its influence on sexual development
Authors: Kostenko T.P. 
Published: December 2022

Objective — to assess the frequency and nature of thyroid gland pathology in children and adolescents with type 1 diabetes mellitus (DM 1) and to determine its impact on somatic and sexual development.
Materials and methods. Investigation involved 117 children and adolescents with DM 1, aged from 9 to 18 years (54 boys and 63 girls), who were under observation in the clinic of the Institute of Children and Adolescents Health Care. All children underwent thyroid gland (TG) ultrasound examination. The assessments included physical and sexual development of patients, the state of carbohydrate metabolism according to the glycosylated hemoglobin (HbA1c) levels. Creation of the database and statistical processing of the results were carried out using the packages of Microsoft Excel and SPSS 17.0 statistical methods.
Results and discussion. Thyropathies were diagnosed in 41.0 % of DM 1 patients (from the, 20.5 % had diffuse nontoxic goiter, 17.1 % autoimmune thyroiditis (AIT), 3.4 % nodules, cysts). AIT was mostly often determined in girls (22.2 %), and diffuse nontoxic goiter in boys (31.5 %). Among boys with harmonious physical development, 51.6 % had thyroid pathology. In case of sexual development abnormalities, almost half of girls (46.7 %) and a third of boys (33.3 %) had thyropathies. Thyropathies were significantly more often identified in adolescents with the DM 1 onset in childhood (71.4 %) and early puberty (80.0 %), duration of diabetes from 5 to 10 years (48.3 %), and suboptimal compensation (63.3 % in boys and 50.0 % in girls).
Conclusions. The high frequency of thyroid pathology has been established among children and adolescents in whom DM 1 developed at the age of 4—5 years (71.4 %). It has been shown that the increased AIT risk exists in both girls and boys. A significant percentage of thyropathies among children in the early puberty period (80.0 %) was established. The obtained results confirmed the need for careful monitoring of the thyroid gland in children and adolescents with DM1, especially in the period of puberty.
علم الفقه في المشرق الإسلامي (132-656 هـ/ 749-1258م)
Authors: AbdulAmeer Maha Waddah 
Published: December 2022

عنوان البحث: علم الفقه في المشرق الإسلامي (132-656 ﮬ/ 749-1258م).
محتويات الدراسة:
المبحث الأول: علم الفقه والفقهاء في المشرق الإسلامي.
المبحث الثاني: علم الفقه والمذاهب الفقهية في المشرق الإسلامي.
المبحث الثالث: اعلام الفقه في المشرق الإسلامي.
يُعد علم الفقه من أهم العلوم الإنسانية التي عرفها العرب المسلمون لارتباطه بالشريعة الإسلامية وبالتالي ارتباطه بحياة الناس اليومية فأصبحوا بحاجة إلى معرفة احكام شريعتهم وذلك لا يتم الا بالرجوع إلى علم الفقه.
لقد ظهرت في المشرق الإسلامي عدة مذاهب ارتبطت بعلم الفقه مثل المذهب الشيعي والحنفي والشافعي وكان المذهب الشافعي أكثر تلك المذاهب انتشاراً في المشرق الإسلامي وقد تأثر علم الفقه تلك المذاهب إذ كان يتراوح بين الخلفاء والقادة العباسيين بين مد وجزر.
من الجدير بالذكر ظهور طائفة من أشهر العلماء في مجال علم الفقه في المشرق الإسلامي في ذلك العصر مثل الغزالي والماتريدي والشاشي وغيرهم قاموا بالدراسة وتولوا التدريس في المدارس الكبرى، كما الفوا المصنفات الكبرى التي شكلت مورداً مهماً من موارد التراث الإنساني.