bluuebunny/crossref_metadata_2025_split huggingface dataset:
The periodic review model with independent age‐dependent lifetimes
Authors: Clarkson Jake , Voelkel Michael A. , Sachs Anna‐Lena , Thonemann Ulrich W. 
Published: October 2022

A retailer places orders periodically for items that are shipped by a wholesaler. Items that are not sold perish randomly and independently of one another, with the perish probability depending on the age class. We consider a first‐in‐first‐out policy for depleting items. We model this problem as a Markov decision process with stochastic demand, unit holding, outdating and ordering costs, plus unit penalty costs for lost sales. We prove convexity for the penultimate period and show convexity may not hold any earlier. A dynamic program can be solved optimally for small instances. We introduce both a one‐stage‐lookahead heuristic and a heuristic which is a combination of two existing standard approaches, the newsvendor and periodic review models. For simulated data, we compare these heuristics to the optimal solution for small problem instances and to further lookahead policies for larger problem instances. We show that the two new heuristics achieve results close to optimal. Our numerical study, which includes real data from a large European retail chain, highlights that products perishing independently from each other strongly affect model behavior compared to existing approaches from the literature.
Effects ofOriganum majoranaessential oil and antibiotics on the quality of frozen thawed Beni Arouss buck semen
Authors: Kchikich Amr , Kirschvink Nathalie , El Kadili Sara , Raes Marianne , El Otmani Samira , Chebli Youssef , Bister Jean‐Loup , El Amiri Bouchra , Barrijal Said , Chentouf Mouad 
Published: October 2022

AbstractThis study aims to investigate the effects ofOriganum majorana(OM) essential oil (EO) at different concentrations and antibiotics on post‐thawed Beni Arouss buck semen quality. Semen collection was performed using artificial vagina from eight Beni Arouss bucks. Ejaculates were pooled, divided into 12 equal aliquots, washed and diluted to 400 × 106sperm/ml (with 7% of glycerol). Skim milk–based extender was supplemented with different concentrations of OM EO (0%; 0.01%; 0.02%; 0.03%; 0.04% and 0.05%) without antibiotics, marked as (CTR−), (M1−), (M2−), (M3−), (M4−) and (M5−), and with 50 mg of streptomycin and 50,000 IU of penicillin per 100 ml, marked as (CTR+), (M1+), (M2+), (M3+), (M4+) and (M5+), respectively. Aliquots were cooled to 4°C, then frozen in 0.25 ml straws with a programmable freezer and finally stored in liquid nitrogen for 48 h. Thawing was performed at 37°C for 30 s. Motility, live sperm, sperm abnormalities, membrane integrity, lipid peroxidation and bacterial growth were evaluated after thawing. Among the tested extenders, M2+ improved all semen quality parameters. Sperm motility, live sperm and membrane integrity increased significantly, while the number of abnormal sperm and bacterial growth decreased significantly. The toxic effect of OM EO, with and without antibiotics, appeared beyond 0.03%. In conclusion, M2+ is recommended to improve the cryopreservation of Beni Arouss buck semen.
It is not all about salary: a discrete-choice experiment to determine community health workers’ motivation for work in Nigeria
Authors: Ajisegiri Whenayon Simeon , Peiris David , Abimbola Seye , Odusanya Olumuyiwa O , Tesema Azeb Gebresilassie , Joshi Rohina , Angell Blake 
Published: October 2022

IntroductionCommunity health workers (CHWs) constitute the majority of primary healthcare (PHC) workers in Nigeria, yet little is understood about their motivations or the most effective interventions to meet their needs to ensure quality health coverage across the country. We aimed to identify factors that would motivate CHWs for quality service delivery.MethodsA discrete-choice experiment was conducted among 300 CHWs across 44 PHC facilities in the Federal Capital Territory, Abuja Nigeria. Based on the literature review and qualitative research, five attributes, namely: salary, educational opportunities, career progression and in-service training, housing and transportation, were included in the experiment. CHWs were presented with 12 unlabelled choice sets, using tablet devices, and asked to choose which of two hypothetical jobs they would accept if offered to them, or whether they would take neither job. Mixed multinomial logistic models were used to estimate stated preferences for the attributes and the likely uptake of jobs under different policy packages was simulated.ResultsAbout 70% of the respondents were women and 39% worked as volunteers. Jobs that offered career progression were the strongest motivators among the formally employed CHWs (β=0.33) while the ‘opportunity to convert from CHW to another cadre of health workers, such as nursing’ was the most important motivator among the volunteers’ CHWs (β=0.53). CHWs also strongly preferred jobs that would offer educational opportunities, including scholarship (β=0.31) and provision of transport allowances (β=0.26). Policy scenario modelling predicted combined educational opportunities, career progression opportunities and an additional 10% of salary as incentives was the employment package that would be most appealing to CHWs.ConclusionCHWs are motivated by a mix of non-financial and financial incentives. Policy interventions that would improve motivation should be adequate to address various contexts facing different CHWs and be flexible enough to meet their differing needs.
Does lactate enhance the prognostic accuracy of the quick Sequential Organ Failure Assessment for adult patients with sepsis? A systematic review
Authors: Gill Angus , Ackermann Khalia , Hughes Clifford , Lam Vincent , Li Ling 
Published: October 2022

ObjectivesTo investigate whether adding lactate to the quick Sequential (sepsis-related) Organ Failure Assessment (qSOFA) improves the prediction of mortality in adult hospital patients, compared with qSOFA alone.DesignSystematic review in accordance with Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies guidelines.Data sourcesEmbase, Medline, PubMed, SCOPUS, Web of Science, CINAHL and Open Grey databases were searched in November 2020.Eligibility criteriaOriginal research studies published after 2016 comparing qSOFA in combination with lactate (LqSOFA) with qSOFA alone in adult patients with sepsis in hospital. The language was restricted to English.Data extraction and synthesisTitle and abstract screening, full-text screening, data extraction and quality assessment (using Quality Assessment of Diagnostic Accuracy Studies-2) were conducted independently by two reviewers. Extracted data were collected into tables and diagnostic test accuracy was compared between the two tests.ResultsWe identified 1621 studies, of which 11 met our inclusion criteria. Overall, there was a low risk of bias across all studies. The area under the receiver operating characteristic (AUROC) curve for qSOFA was improved by the addition of lactate in 9 of the 10 studies reporting it. Sensitivity was increased in three of seven studies that reported it. Specificity was increased in four of seven studies that reported it. Of the six studies set exclusively within the emergency department, five published AUROCs, all of which reported an increase following the addition of lactate. Sensitivity and specificity results varied throughout the included studies. Due to insufficient data and heterogeneity of studies, a meta-analysis was not performed.ConclusionsLqSOFA is an effective tool for identifying mortality risk both in adult inpatients with sepsis and those in the emergency department. LqSOFA increases AUROC over qSOFA alone, particularly within the emergency department. However, further original research is required to provide a stronger base of evidence in lactate measurement timing, as well as prospective trials to strengthen evidence and reduce bias.PROSPERO registration numberCRD42020207648.
What is the impact of introducing a non-clinical community health advice and navigation service on the demand for primary care in socially deprived areas? Evidence from an observational panel study with difference-in-differences design
Authors: Wild Eva-Maria , Winter Vera , Ress Vanessa , Golubinski Veronika 
Published: October 2022

ObjectivesTo examine the effect of introducing a non-clinical community health advice and navigation service on the demand for primary care in a socially deprived area.DesignObservational panel study with difference-in-differences design. We conducted fixed-effects negative binomial regressions to compare changes in the number of visits to general practitioners (GPs) in individuals who visited the health advice and navigation service and a matched control group of individuals who did not visit the service. In addition, we analysed the effects of visiting the service multiple times.Setting and participantsOur empirical setting is a socially deprived urban area in Germany with a multicultural population of about 110 000 people. Our analyses are based on patient data (N=1044) from a non-clinical community health advice and navigation service and from two statutory health insurers.Outcome measuresPatient demand for primary care measured as the number of visits to GPs before and after the first visit to the health advice and navigation service.ResultsVisiting the service for the first time significantly decreased the number of GP visits compared with the control group (β=−0.113, p<0.1). Each additional visit to the service, however, significantly decreased the effect of the first visit (β=0.037, p<0.05).ConclusionsOur findings suggest that non-clinical community health advice and navigation services can serve as a low-threshold first point of contact. As first point contact, such services might possibly reduce the burden of primary care physicians in socially deprived areas. At the same time, such services might function as a gateway to accessing the health system, reducing unmet care needs and stimulate demand. Ongoing counselling in the service can identify medical needs that require a physician visit. Our findings may be useful for policymakers and healthcare leaders seeking to reduce the demand on the primary care workforce and can stimulate further research in this area.
Comprehensive geriatric assessment (CGA) in perioperative care: a systematic review of a complex intervention
Authors: Miller Rachael Lucia , Barnes Jonathan David , Mouton Ronelle , Braude Philip , Hinchliffe Robert 
Published: October 2022

ObjectivesComprehensive geriatric assessment (CGA) is a complex intervention applied to older people with evidence of benefit in medical populations. The aim of this systematic review was to describe how CGA is applied to surgical populations in randomised controlled trials. This will provide a basis for design of future studies focused on optimising CGA as a complex intervention.SettingA systematic review of randomised controlled trials.ParticipantsA systematic search was performed for studies of CGA in the perioperative period across Ovid MEDLINE, Ovid EMBASE, CINAHL and Cochrane CENTRAL, from inception to March 2021.InterventionsAny randomised controlled trials of perioperative CGA versus ‘standard care’ were included.Outcome measuresQualitative description of CGA.Results12 121 titles and abstracts were screened, 68 full-text articles were assessed for eligibility and 22 articles included, reporting on 13 trials. 10 trials focused on inpatients with hip fracture, with 7 of these delivering CGA on a geriatric medicine ward, 3 on a surgical ward. The remaining three trials were in elective general surgery all delivering CGA on a surgical ward. CGA components, duration of intervention and personnel delivering the intervention were highly variable across the different studies. Trials favoured postoperative delivery of CGA (11/13). Only four trials reported data on adherence to the CGA intervention.ConclusionsCGA as an intervention is variably described and delivered in randomised controlled trials in the perioperative setting. The reporting of both the intervention and standard care is often poor with little focus on adherence. Future research should focus on clearly defining and standardising the intervention as well as measuring adherence within trials.PROSPERO registration numberCRD42020221797.
Use of a bDMARD or tsDMARD for the management of inflammatory arthritis under checkpoint inhibitors: an observational study
Authors: De La Fuente Fanny , Belkhir Rakiba , Henry Julien , Nguyen Chi Duc , Pham Thao , Germain Vincent , Gavand Pierre Edouard , Labadie Céline , Briere Claire , Lauret Ambre , Cardon Thierry , Mouterde Gael , Bonnet Isabelle , Rouxel Léa , Truchetet Marie-Elise , Schaeverbeke Thierry , Richez Christophe , Kostine Marie 
Published: October 2022

ObjectiveThere is limited experience regarding the use of biological disease-modifying antirheumatic drug (bDMARD) and JAK inhibitor (JAKi) for the management of immune checkpoint inhibitors (ICI)-induced inflammatory arthritis. We aimed to assess their efficacy and safety in this setting.MethodsUsing the Club Rhumatismes and Inflammation French network, we conducted a multicentre, retrospective, observational study of patients with cancer diagnosed with inflammatory arthritis under ICI(s) and treated with bDMARD or JAKi. Clinical data were collected using a standardised case report form.ResultsTwenty patients (60% men, median age 69.5 years) were included, with rheumatoid arthritis (RA)-like (n=16), polymyalgia rheumatica-like (n=2) or psoriatic arthritis-like (n=2) clinical presentation. Two patients had pre-existing RA. 90% were treated with glucocorticoids as first-line therapy and 60% received methotrexate prior to bDMARD or JAKi. Anti-interleukin-6 receptor (IL-6R) therapy was used in 13/20 patients (65%), leading to clinical improvement in 11/13 patients (85%), but one patient experienced intestinal perforation and cancer progression was noticed in 6/13 patients (46%). Tumour necrosis factor inhibitors were used in 5/20 patients (25%), with improvement in 4/5 patients (80%) and cancer progression was observed in 3/5 patients (60%). Two infections (diverticulitis and pneumonitis) were reported. Anakinra, baricitinib and ustekinumab were each used in one patient. Median duration of the bDMARD or JAKi was 17 weeks.ConclusionAnti-IL-6R therapy is currently the most common strategy in patients with ICI-induced inflammatory arthritis and insufficient response to glucocorticoids and methotrexate, leading to improvement in >80%. Overall, cancer progression occurred in about half of patients and whether the bDMARD/JAKi impacted the tumour response remains to be determined.
Comparative study of the effects of high- versus low-dose zinc oxide in the diet with or without probiotic supplementation on weaning pigs' growth performance, nutrient utilization, fecal microbes, noxious gas discharges, and fecal score
Authors: Biswas Sarbani , Kim Min Hee , Park Jae Hong , Kim Yangseon , Kim In Ho 
Published: October 2022

This study was conducted to determine the effects of high- versus low-dose (3000 vs. 300) zinc oxide (ZnO) in combination with or without a probiotic complex (0.1%) on weaned piglet production efficiency, nutrient absorption, fecal bacterial counts, noxious gas emissions, and fecal score. A 42-day experiment included 180 crossbred weaned piglets [Duroc × (Yorkshire × Landrace); 28 days old; 6.61 ± 1.29 kg] and four dietary treatments. An HZ (high ZnO) diet increased body weight at week 6, average daily gain at week 3, week 6, and overall period, and gain-to-feed ratio (G:F) at week 3 compared with an LZ (low ZnO) diet. G:F tended to increase with the LZP (LZ with probiotic) diet compared with the HZP (HZ with probiotic) diet at week 1. Escherichia coli count decreased by HZ diet compared with the LZ diet. In addition, E. coli count decreased and Lactobacillus count increased with the HZP diet compared with the LZP diet. There was no effect of treatment on nutrient digestibility, noxious gas emission, and fecal score. No interactive effect was seen between ZnO and probiotic. Therefore, high-dose ZnO inclusion improved growth performance and probiotic addition improved fecal microbiota, but no synergistic effect was found from ZnO and probiotic complex interaction.
Immunomodulatory Cell Therapy Using αGalCer-Pulsed Dendritic Cells Ameliorates Heart Failure in a Murine Dilated Cardiomyopathy Model
Authors: Ikeda Masataka , Ide Tomomi , Matsushima Shouji , Ikeda Soichiro , Okabe Kosuke , Ishikita Akihito , Tadokoro Tomonori , Sada Masashi , Abe Ko , Sato Midori , Hanada Akiko , Arai Shinobu , Ohtani Kisho , Nonami Atsushi , Mizuno Shinichi , Morimoto Sachio , Motohashi Shinichiro , Akashi Koichi , Taniguchi Masaru , Tsutsui Hiroyuki 
Published: October 2022

Background:
Dilated cardiomyopathy (DCM) is a life-threatening disease, resulting in refractory heart failure. An immune disorder underlies the pathophysiology associated with heart failure progression. Invariant natural killer T (iNKT) cell activation is a prospective therapeutic strategy for ischemic heart disease. However, its efficacy in nonischemic cardiomyopathy, such as DCM, remains to be elucidated, and the feasible modality for iNKT cell activation in humans is yet to be validated.

Methods:

Dendritic cells isolated from human volunteers were pulsed with α-galactosylceramide ex vivo, which were used as α-galactosylceramide-pulsed dendritic cells (αGCDCs). We treated DCM mice harboring mutated troponin T
ΔK210/ΔK210
with αGCDCs and evaluated the efficacy of iNKT cell activation on heart failure in DCM mice. Furthermore, we investigated the molecular basis underlying its therapeutic effects in these mice and analyzed primary cardiac cells under iNKT cell-secreted cytokines.

Results:

The number of iNKT cells in the spleens of DCM mice was reduced compared with that in wild-type mice, whereas αGCDC treatment activated iNKT cells, prolonged survival of DCM mice, and prevented decline in the left ventricular ejection fraction for 4 weeks, accompanied by suppressed interstitial fibrosis. Mechanistically, αGCDC treatment suppressed TGF (transforming growth factor)-β signaling and expression of fibrotic genes and restored vasculature that was impaired in DCM hearts by upregulating angiopoietin 1 (
Angpt1
) expression. Consistently, IFNγ (interferon gamma) suppressed TGF-β-induced Smad2/3 signaling and the expression of fibrotic genes in cardiac fibroblasts and upregulated
Angpt1
expression in cardiomyocytes via Stat1.

Conclusions:
Immunomodulatory cell therapy with αGCDCs is a novel therapeutic strategy for heart failure in DCM.
A Generalised Dropout Mechanism for Distributed Systems
Authors: Bull Larry , Liu Haixia 
Published: October 2022

AbstractThis letter uses a modified form of the NK model introduced to explore aspects of distributed control. In particular, a previous result suggesting the use of dynamically formed subgroups within the overall system can be more effective than global control is further explored. The conditions under which the beneficial distributed control emerges are more clearly identified, and the reason for the benefit over traditional global control is suggested as a generally applicable dropout mechanism to improve learning in such systems.
Culturescape: Environment, Science, and Art at Bundanon
Authors: Helyer Nigel , Potts John 
Published: October 2022

Abstract
This article describes the website Culturescape: An Environmental Portrait of Bundanon. This online portrait, a collaboration combining environmental science and art, includes an interactive environmental map of the Bundanon region in New South Wales, Australia, and documentation of environmental artworks by Nigel Helyer, all initially installed at Bundanon. The interactive map displays soil quality data at Bundanon in sonified and visualized form. The user hears a sonification of environmental data, represented as a musical piece, and sees a visualization of mineral data as a graphic display.
Inferior vena cava perforation during percutaneous filter removal
Authors: Hicks Adam C , Sangroula Daisy , Dwivedi Amit J , Wayne Erik J , Sigdel Abindra 
Published: October 2022

Background Percutaneous Inferior Venacava (IVC) filter retrieval can be challenging when the filter is grossly angulated, embedded in the wall or penetrates through the IVC. When conventional filter removal technique fails, the use of advanced retrieval techniques often improves the chances of percutaneous filter retrieval. These techniques, however, are associated with a high rate of complications. Methods We report a case of 26-year-old female who had IVC filter placed on postpartum day 4. Attempted percutaneous filter retrieval 3 weeks later with loop snare technique and endobronchial forceps assisted filter removal technique resulted in gross filter deformity, malposition, and IVC perforation. Result Open IVC filter removal was performed with midline laparotomy and cavotomy with lateral venorrhapy. The deformed filter along with adherent thrombus was completely removed. The patient had an uneventful recovery with no immediate or long-term complications. Conclusion Use of advanced endovascular IVC filter retrieval techniques could result in serious complications like filter fracture, migration and IVC perforation. Since excessive tilt of the filter at the time of placement often results in difficult retrieval, it is important to ensure proper deployment of the filter with minimal tilt. If encountered with excessively tilted or embedded filter, one should refrain from excessive manipulation of the filter and consider open filter removal.
The effect of cognitive-behavioral therapy on stress and anxiety of women with premature ovarian insufficiency: A randomized controlled trial
Authors: Shabani Fatemeh , Farvareshi Mahmoud , Hamdi Kobra , Sadeghzadeh Oskouei Behnaz , Montazeri Maryam , Mirghafourvand Mojgan 
Published: October 2022

The aim of this study was to determine the effect of cognitive-behavioral therapy (CBT) on stress and anxiety (primary outcomes) and self-esteem and depression (secondary outcomes) in women with premature ovarian insufficiency (POI). This randomized controlled trial was performed on 50 women known with POI in Tabriz, Iran, in 2021. Participants were randomly assigned to CBT and control groups. CBT was provided in eight sessions of 45–60 min once a week with five to seven people. The Spielberger State-Trait Anxiety Inventory, Cohen Perceived Stress Scale, Beck Depression Inventory, and Rosenberg Self-Esteem Scale were used to collect data. After intervention, based on ANCOVA test by adjusting the baseline values, mean scores of stress (AMD: −10.97; 95% CI: −11.64 to −10.29), state anxiety (AMD: −14.76; 95% CI: −15.77 to −13.74), trait anxiety (AMD: −14.41; 95% CI: −15.47 to −13.74), and depression (AMD: −7.44; 95% CI: −8.41 to −6.46) were significantly lower in the CBT group compared to the control group. Also, mean score of self-esteem (AMD: 1.49; 95% CI: 1.06–1.92) was significantly higher in the CBT group compared to the control group. Regarding the effectiveness of CBT in promoting of mental health, it is suggested that healthcare providers use this method to improve mental health of women with POI. Trial registration Iranian Registry of Clinical Trials (IRCT): IRCT20120718010324N64. Date of registration: 14/02/2021. URL: https://en.irct.ir/user/trial/52024/view; date of first registration: 17/02/2021.