bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of dosimetry and predictive somatotype parameters of prone and supine whole-breast irradiation among Chinese women after breast-conserving surgery
Authors: Gao Yi , Wang Li , Bai Han , Pan Xiang , Li Lan , Chang Li , Xia Yaoxiong , Li Wenhui , Hou Yu 
Published: November 2022

PurposeFinding a better treatment position (prone or supine) for whole-breast irradiation for Chinese female patients diagnosed with breast cancer by identify the associations between predictive somatotype parameters and dosimetric gains.Materials and methodsTwo volumetric-modulated arc therapy (VMAT) plans were deployed for whole-breast irradiation in supine and prone position with a total dose of 50 Gy in 25 fractions. Dose-volume parameters were compared and analysed both in the target volume and organs at risk, and equivalent uniform dose-based figure-of-merit (fEUD) models were further used to quantitatively evaluate the overall merits of the two plans. Body shape parameters, including body mass index (BMI), body surface area (BSA), breast shape, cup size, bust size and chest size, were collected. Anatomic features such as the central heart distance (CHD) were measured on supine CT. Spearman’s correlation analysis, receiver operating characteristic (ROC) curve analysis, and the linear regression models were conducted.ResultsDoses to the heart and left anterior descending coronary artery (LADCA) are greater in left-sided breast cancer (BC) patients in the prone position than in the supine position, and the opposite was true for right-sided BC patients (p&lt;0.001). 19 of 63 patients (5 left-sided and 14 right-sided BC) achieved greater benefit from the prone position according to the fEUD score. Right-sided BC patients with a bust size ≥92.25 cm, drop-type breasts and cup size ≥B are very likely to benefit from prone-position radiotherapy. The CHD is significantly positively associated with △fEUD among right-sided BC patients (rho=0.506, p=0.004). Using a cut-off point of 2.215, the CHD had 71.4% sensitivity and 81.2% specificity in predicting a successful prone plan.ConclusionsRight-sided BC patients had better dosimetric gain in the prone position than left-sided BC patients. The CHD is an especially good and novel predictor that could help to select prone-benefitting right-sided BC patients.
Survival benefit of primary tumor resection for gastric cancer with liver metastasis: A propensity score-matched, population-based study
Authors: Wu Jiayan , Yu Jiandong , Chen Zhiping , Zhu Hongquan , Zhong Chengrui , Liang Yongling , Mai Ziyan , Lin Zejin , Wan Yunle , Li Guolin 
Published: November 2022

ObjectivesGastric cancer with liver metastasis (GCLM) is highly aggressive and has a poor prognosis. This study aims to evaluate the survival benefit of primary tumor resection (PTR) for gastric cancer with liver metastasis.MethodsData on patients with GCLM was extracted from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. A 1:1 propensity score matching (PSM) analysis was performed to minimize the heterogeneity between the PTR and no-PTR groups. The Kaplan–Meier method and Cox regression analysis were used to assess the impact of primary tumor resection (PTR) on overall survival (OS) and cause-specific survival (CSS).ResultsA total of 3,001 patients with GCLM were included, with 328 patients treated with primary tumor resection (PTR), whereas the other 2,673 patients were not. Patients with PTR had a significantly higher OS and CSS rate than those without PTR in unmatched and PSM cohorts. In an unmatched cohort, the median OS was 12.0 months (95% CI, 10 months to 14 months) for those who underwent PTR and 4 months (95% CI, 4 months to 5 months) for those without PTR; the median CSS for those who underwent PTR was 12.0 months (95% CI, 10 months to14 months) and 4 months (95% CI, 4 months to 5 months) for those without PTR, respectively. After PMS, the median OS was 12.0 months (95% CI, 10 months to 17 months) for those who underwent PTR and 7 months (95% CI, 5 months to 10 months) for those without PTR, respectively; the median CSS for those who underwent PTR was 12.0 months (95% CI, 11 months to 17 months) and 7 months (95% CI, 5 months to 8 months) for those without PTR, respectively. In addition, multivariate Cox analysis in the PSM cohort showed that PTR, age, degree of tumor differentiation, and chemotherapy were independent prognostic factors for OS and CSS in GCLM. Specifically, PTR was a significant protective factor for OS (HR: 0.427; 95% CI, 0.325 to 0.561, P &lt;0.001) and CSS (HR: 0.419; 95% CI, 0.313 to 0.561, P &lt;0.001).ConclusionPrimary tumor resection improves the survival of gastric cancer patients with liver metastasis.
Study protocol for comparing the efficacy of left-open single-flap technique versus double-flap technique after proximal gastrectomy: A multicenter randomized controlled trial
Authors: Yang Qin Chuan , Wang Wei Dong , Mo Zhen Chang , Yue Chao , Zhou Hai Kun , Gao Rui Qi , Yu Juan , Dong Dan Hong , Liu Jin Qiang , Wei Jiang Peng , Yang Xi Sheng , Ji Gang , Li Xiao Hua 
Published: November 2022

BackgroundProximal gastrectomy has gradually gained more attention due to its superiority in retaining the function of part of the stomach. The inevitable loss of the antireflux barrier and postoperative complications resulting from proximal gastrectomy can severely affect the quality of life. Continuous improvements in digestive tract reconstruction after proximal gastrectomy have yielded the development of a variety of methods with antireflux functions. Recently, our center attempted the left-open single-flap technique and initiated a multicenter, prospective, randomized controlled trial for patients undergoing proximal gastrectomy to reduce the difficulty of surgical anastomosis and the incidence of perioperative complications compared with the double-flap technique. These findings will provide more evidence-based medical research for the development of clinical guidelines.Methods/designThis study is a prospective, multicenter, randomized controlled clinical trial. We plan to recruit 250 patients who are eligible for proximal gastrectomy. After informed consent is obtained, patients will be randomly assigned to the trial group (left-open single-flap technique) and the control group (double-flap technique) in a 1:1 allocation ratio.DiscussionIncreasingly, clinical studies have focused on the improvement of reconstruction modalities after proximal gastrectomy. Among these methods, the double-flap technique is a clinically effective method. The purpose of this study is to establish a prospective randomized controlled trial to compare the efficacy of the left-open single-flap technique versus the double-flap technique after proximal gastrectomy, aiming to provide more evidence-based medical studies for digestive tract reconstruction in proximal gastrectomy.Clinical Trial RegistrationClinicalTrials.gov, identifier [NCT05418920].
Energy metabolism in skeletal muscle cells from donors with different body mass index
Authors: Katare Parmeshwar B. , Dalmao-Fernandez Andrea , Mengeste Abel M. , Hamarsland Håvard , Ellefsen Stian , Bakke Hege G. , Kase Eili Tranheim , Thoresen G. Hege , Rustan Arild C. 
Published: November 2022

Obesity and physical inactivity have a profound impact on skeletal muscle metabolism. In the present work, we have investigated differences in protein expression and energy metabolism in primary human skeletal muscle cells established from lean donors (BMI&lt;25 kg/m2) and individuals with obesity (BMI&gt;30 kg/m2). Furthermore, we have studied the effect of fatty acid pretreatment on energy metabolism in myotubes from these donor groups. Alterations in protein expression were investigated using proteomic analysis, and energy metabolism was studied using radiolabeled substrates. Gene Ontology enrichment analysis showed that glycolytic, apoptotic, and hypoxia pathways were upregulated, whereas the pentose phosphate pathway was downregulated in myotubes from donors with obesity compared to myotubes from lean donors. Moreover, fatty acid, glucose, and amino acid uptake were increased in myotubes from individuals with obesity. However, fatty acid oxidation was reduced, glucose oxidation was increased in myotubes from subjects with obesity compared to cells from lean. Pretreatment of myotubes with palmitic acid (PA) or eicosapentaenoic acid (EPA) for 24 h increased glucose oxidation and oleic acid uptake. EPA pretreatment increased the glucose and fatty acid uptake and reduced leucine fractional oxidation in myotubes from donors with obesity. In conclusion, these results suggest that myotubes from individuals with obesity showed increased fatty acid, glucose, and amino acid uptake compared to cells from lean donors. Furthermore, myotubes from individuals with obesity had reduced fatty acid oxidative capacity, increased glucose oxidation, and a higher glycolytic reserve capacity compared to cells from lean donors. Fatty acid pretreatment enhances glucose metabolism, and EPA reduces oleic acid and leucine fractional oxidation in myotubes from donor with obesity, suggesting increased metabolic flexibility after EPA treatment.
Glycemic control and the risk of tuberculosis in patients with diabetes: A cohort study in a Mediterranean city
Authors: Antonio-Arques Violeta , Caylà Joan A. , Real Jordi , Moreno-Martinez Antonio , Orcau Àngels , Mauricio Didac , Mata-Cases Manel , Julve Josep , Navas Mendez Elena , Puig Treserra Rai , Millet Joan Pau , Del Val García Jose Luis , Vlacho Bogdan , Franch-Nadal Josep 
Published: November 2022

BackgroundDiabetes mellitus (DM) is one of the leading chronic diseases globally and one of the most common causes of death, morbidity, and poor quality of life. According to the WHO, DM is also one of the main risk factors for developing active tuberculosis (TB). Subjects with DM are at a higher risk of infections, in addition to frequent micro and macrovascular complications, and therefore sought to determine whether poor glycemic control is linked to a higher risk of developing TB.MethodsWe used a retrospective cohort of diabetic subjects to predict the incidence of TB. All DM patients were recruited from Ciutat Vella (the inner-city of Barcelona) from January 2007 until December 2016, with a follow-up period until December 2018 (≥2 years). Data were extracted from Barcelona's Primary Care medical record database - SIDIAP, and linked to the Barcelona TB Control Program. The incidence of TB and the impact of glycemic control were estimated using time-to-event curves analyzed by Cox proportional hazard regression. Hazard ratios (HRs) and 95% confidence intervals (CIs), unadjusted and adjusted by potential confounding variables, were also assessed, which included age, sex, diabetes duration, macrovascular and microvascular signs, BMI, smoking habit, alcohol consumption and geographical origin.ResultsOf 8,004 DM patients considered for the study (equating to 68,605 person-years of follow-up), 84 developed TB [incidence rate = 70 (95% CI: 52–93) per 100,000 person-years]. DM subjects with TB were younger (mean: 52.2 vs. 57.7 years old), had higher values of glycosylated hemoglobin (HbA1c) (7.66 vs. 7.41%) and total triglycerides (122 vs. 105 mg/dl), and had twice the frequency of diabetic nephropathy (2.08 vs. 1.18%). The calculated incidence rate increased with increasing HbA1c: 120.5 (95% CI 77.2–179.3) for HbA1c ≥ 7.5%, 143 (95% CI 88.3–218.1) for HbA1c ≥ 8% and 183.8 (95% CI 105–298) for HbA1c ≥ 9%. An increase in the risk of TB was also observed according to a poorer optimization of glycemic control: adjusted HR 1.80 (95% CI 0.60–5.42), 2.06 (95% CI 0.67–6.32), and 2.82 (95% CI 0.88–9.06), respectively.ConclusionDiabetic subjects with worse glycemic control show a trend toward a higher risk of developing TB.
The rate of acute kidney injury (AKI) alert detection by the attending physicians was associated with the prognosis of patients with AKI
Authors: Shi Yu , Wang Hai , Bai Ling , Wu Yuan , Zhang Li , Zheng Xin , Lv Jun-hua , Pei Hong-hong , Bai Zheng-hai 
Published: November 2022

IntroductionEarly identification of AKI was always considered to improve patients' prognosis. Some studies found that AKI early warning tools didn't affect patients' prognosis. Therefore, additional studies were necessary to explore the reasons.MethodsThis study was a secondary analysis of a multicenter randomized controlled trial that found electronic health record warnings for AKI did not influence patients' prognoses. Univariate, multivariate, subgroup, curve fitting, and threshold effect analysis were used to explore the association between AKI warnings detected by attending physicians and the patient's prognosis.ResultsA total of 6,030 AKI patients were included in the study. The patients were classified into two groups based on the rate of AKI alerts detected by attending physicians: the partial group (n = 5,377), and the complete group (n = 653). In comparison to the partial group, the complete group significantly decreased 14-day AKI progression, 14-day dialysis, and 14-day mortality, with adjusted ORs of 0.48 (0.33, 0.70), 0.26 (0.09, 0.77), and 0.53 (0.33, 0.84) respectively, and the complete group significantly improve the discharge to home, with an OR value of 1.50 (1.21, 1.87). When the rate of AKI alerts detected by the attending physicians as a continuity variable, we found that the rate of alerts seen by attending physicians was associated with 14-day mortality and the discharge to home, with adjusted ORs of 1.76 (1.11, 2.81) and 1.42 (1.13, 1.80). The sensitivity analysis, curve-fitting analysis, and threshold effect analysis also showed that the rate of alert seen by the attending physician was correlated with the patient's prognosis.ConclusionThe rate of AKI alert detection by attending physician were related to the patient's prognosis. The higher the rate of AKI alert detection by attending physicians, the better the prognosis of patients with AKI.
Characterization of Phytochemical and Nutrient Compounds from the Leaves and Seeds of Moringa oleifera and Moringa peregrina
Authors: Abdalla Heba A. M. , Ali Mohammed , Amar Mohamed Hamdy , Chen Lingyun , Wang Qing-Feng 
Published: November 2022

Moringa oleifera and M. peregrina are robust and fast-growing trees. These trees are considered some of the most highly valued trees worldwide because of their properties and uses. This study aimed to investigate and determine the content of phytochemical and nutrient compounds in the fresh leaves and the mature seeds of both M. oleifera and M. peregrina. The experimental data analysis showed that all four extracts were rich in proximate minerals, fatty acids (FA), and un-saponified and polyphenolic components. The total percentages of saturated and unsaturated fatty acids compounds obtained from the leaves and seeds of M. oleifera and M. peregrina were (45.02 and 54.93%), (10.80 and 89.19%), (37.13 and 62.8%), and (11.95 and 88.03%), respectively. The major polyphenols compositions were identified as gallic acid, chlorogenic acid, methyl gallate, and coffeic acid. The outcomes of the present study indicate that the leaves and seeds of Egyptian Moringa (M. oleifera and M. peregrina) contain various phytochemical and nutrient compounds, which can provide several health advantages and play an important role in the metabolism of the human body, especially in diseases such as atherosclerosis, heart disease, obesity, and high cholesterol and triglycerides.
Nematicidal Metabolites from the Actinomycete Micromonospora sp. WH06
Authors: Ran Yuan , Zhang Yu , Wang Xin , Li Guohong 
Published: November 2022

A nematicidal actinomycete strain WH06 was isolated from soil samples and was identified using 16S rRNA as Micromonospora sp. Through medium screening and fermentation, 10 metabolites were isolated from the ethyl acetate extract of its fermentation broth using Sephadex LH-20 and silica gel column chromatography. These compounds were identified as N-acetyltyramine (1), N-acetyltryptamine (2), 1-methylhydantoin (3), benzenepropanoic acid (4), cyclo-(L-Pro-L-Tyr) (5), cyclo(L-Phe-Gly) (6), catechol (7), methyl (4-hydroxyphenyl)acetate (8), 3-hydroxybenzoic acid (9), and 4-hydroxybenzoic acid (10). In an in vitro assay against Meloidogyne incognita, a root-knot nematode, compounds 1, 4, 9, and 10 show nematicidal activity. Among them, benzenepropanoic acid (4) causes 99.02% mortality of nematode at 200 μg mL−1 after 72 h. Moreover, compound 4 also displays activity in inhibiting egg hatching of M. incognita. This suggests that Micromonospora sp. WH06 is a promising candidate for biocontrol of M. incognita.
Implementasi Undang-Undang Cipta Kerja dalam Memberikan Kemudahan Untuk Berinvestasi di Indonesia
Authors: Dinda Karina Aisyah 
Published: November 2022

Pengesahan Undang-Undang Nomor 11 Tahun 2020 tentang Cipta Kerja mendorong investasi dengan sistem perizinan yang sederhana. Proses perizinan kegiatan usaha kini telah diubah dari berbasis izin menjadi berbasis risiko. Sistem yang disebut Perizinan Berbasis Risiko bisa didapatkan secara daring melalui Online Single Submission Risk untuk Approach (OSS-RBA). Pemerintah terus berupaya untuk mempermudah arus investasi, diantaranya dengan menginisiasikan lahirnya Undang-Undang (UU) Cipta Kerja. Masyarakat pun mengapresiasi implementasi UU Cipta Kerja yang diharapkan dapat segera mendorong pemulihan ekonomi terdampak pandemi Covid-19. Menteri Investasi/Kepala Badan Koordinasi Penanaman Modal (BKPM) Bahlil Lahadalia mengatakan, Undang undang (UU) Cipta Kerja memiliki dampak positif untuk perekonomian Indonesia khususnya dalam upaya peningkatan realisasi investasi yang ada pada sistem perekonomian Indonesia. Sebab salah satu poin penting yang diatur dalam regulasi ini adalah mempermudah perizinan berusaha. Pada kesempatan Economic Outlook 2022, dikatakan bahwa, salah satu substansi undang-undang Cipta Kerja adalah perizinan untuk investasi. Jadi Undang-Undang Cipta Kerja merupakan pintu jalan untuk meningkatkan realisasi investasi di tahun 2022. Kata kunci : Undang-Undang Cipta Kerja; Investasi; PerizinanABSTRACT The ratification of Law Number 11 of 2020 concerning Job Creation encourages investment with a simple licensing system. The business activity licensing process has now been changed from permit-based to risk-based. A system called Risk-Based Licensing can be obtained online through the Online Single Submission Risk for Approach (OSS-RBA). The government continues to strive to facilitate the flow of investment, including by initiating the birth of the Job Creation Law. The public also appreciates the implementation of the Job Creation Act which is expected to immediately encourage economic recovery affected by the Covid-19 pandemic. The Minister of Investment/Head of the Investment Coordinating Board (BKPM) stated that the Job Creation Act has a positive impact on the Indonesian economy, especially in efforts to increase the realization of existing investments in the Indonesian economic system. Because one of the important points regulated in this regulation is to facilitate business licensing. On the occasion of the 2022 Economic Outlook, it was said that, one of the substances of the job creation law is licensing for investment. So the Job Creation Act is a gateway to increase investment realization in 2022. Keyword : Job Creation Law; Investation; Permission
ECONOMIC ASPECTS OF THE USE OF SINGLE-MODE FIBER OPTIC TECHNOLOGY IN THE INFORMATION SYSTEM OF THE DATA CENTER'S COMPUTER ROOM
Authors: Зубилевич А.Л. , Семенов А.Б. , Сиднев С.А. , Царенко В.А. 
Published: November 2022

Рассмотрена проблема выбора типа волоконно-оптической элементной базы для построения канального и физического уровней информационной инфраструктуры машинного зала центра обработки данных (ЦОД) с учетом ее модернизации в процессе текущей эксплуатации. Показана целесообразность выбора показателя экономической эффективности NPV как основного критерия принятия решения. Адекватность предлагаемой модели усилена учетом фактора неопределенности по показателю Гурвица. Представлены аналитические выражения и результаты расчета.
The problem of choosing the type of fiber-optic element base for building the channel and physical levels of the information infrastructure of the data center's computer room, taking into account its modernization in the course of day-to-day operation, is considered. The expediency of choosing the NPV economic efficiency indicator as the main criterion for decision-making is shown. The adequacy of the proposed model is enhanced by taking into account the uncertainty factor in the Hurwitz indicator. Analytical expressions and calculation results are presented.
Thermal expansion coefficient and bulk modulus of silicides
Authors: Imai Motoharu , Hiroto Takanobu 
Published: November 2022

Abstract
The volumetric thermal expansion coefficient α
V is discussed in relation to the bulk modulus B
0 for transition-metal disilicides (TrSi2), alkaline-Earth metal disilicides (AeSi2), Mg2Si, and Si clathrates. For this purpose, the α
V of CoSi2 at 300 K is determined to be 3.1 × 10−5 K−1 using powder X-ray diffraction measurements at temperatures ranging from 300 to 835 K. AeSi2 and Mg2Si have B
0 values ranging from 27.9 to 52.9 GPa, while the values for α
V range from 3.2 × 10−5 to 4.8 × 10−5 K−1. TrSi2 including CoSi2 has larger B
0 values ranging from 148.9 to 243 GPa and smaller α
V values ranging from 2.3 × 10−5 to 3.3 × 10−5 K−1 than AeSi2. Si clathrates have intermediate values of α
V and B
0, which are in between those of TrSi2 and AeSi2. Thus, the silicides with small B
0 values tend to have large α
V values.