bluuebunny/crossref_metadata_2025_split huggingface dataset:
Specific histamine regulating activity of surface‐modified yeast vacuoles by histamine‐ binding protein and its immune‐enhancing effect
Authors: Jang Hyeweon , Kim Yang‐Hoon , Min Jiho 
Published: August 2022

AbstractWe aimed to develop a biocompatible material that could enhance weakened immunity and control histamine in vivo. Histamine‐binding protein (HBP) vacuoles have a mechanism of action that directly binds to the histamine molecule. It is designed to eliminate the side effects of antihistamine caused by binding to other receptors. HBP vacuoles were designed to produce a material that was biocompatible, and could enhance immunity. First, a recombinant vector was designed so that HBP was located on the vacuole surface, and expressed towards the cytoplasm. The vector was transformed into yeast, and protein expression was induced. Then, the vacuole was isolated by centrifugation to complete HBP vacuoles. Cytotoxicity test was conducted for application to RAW 264.7 cells. In addition, immune enhancement reaction and histamine inhibition were confirmed through phagocytosis assay and histamine ELISA. RAW 264.7 cells were pre‐treated with HBP vacuoles to confirm the immune enhancement of HBP vacuoles. As a result, it was confirmed that the immunostimulatory effect of the vacuole was increased in a concentration‐dependent manner. In addition, the reduction of histamine was confirmed by treating the HBP vacuoles. As a result, HBP vacuoles reduced the histamine secreted from RAW 264.7 cells by about 75%.
Systemic lupus erythematosus following human papillomavirus vaccination: A case‐based review
Authors: He Nan , Leng Xiaomei , Zeng Xiaofeng 
Published: August 2022

AbstractSystemic lupus erythematosus (SLE) is a heterogeneous systemic autoimmune diseases (AIDs) with many pathogenic factors, ranging from genetic to epigenetic to environmental. The human papillomavirus (HPV), a viral infectious agent, is a common contributor to the onset and exacerbation of SLE. HPV infections are more prevalent among SLE patients than healthy individuals, bringing about a substantial need for treatment. While HPV recombinant gene vaccines are accepted as a universal method for infection prevention, they pose a risk for adverse events such as fever, joint pain, and rashes. In rare cases, they might even trigger AIDs such as SLE, especially in patients with a personal or family history of such diseases. In this article, we provide a report of a case of SLE onset following HPV vaccination and a review of 11 similar cases. An analysis of 12 patients revealed that 7 cases of SLE developed between 3 weeks and 2 months post‐vaccination. Symptoms of SLE generally manifest as fatigue, fever, joint pain, and myalgia. Two patients had lupus nephritis, 2 showed central nervous system involvement, including abnormal behavior and epileptic seizures, and 1 had intestinal pseudo‐obstruction. All patients showed rapid remission with glucocorticoid and immunosuppressive therapy and remained stable during several months of follow‐up.
Immune checkpoint inhibitors and tyrosine kinase inhibitors in patients with advanced hepatocellular carcinoma: Does the sequence matter?
Authors: Ng Kennedy Yao Yi , Wong Lawrence Wen Jun , Ang Andrea Jing Shi , Lee Ailica Wan Xin , Tay Desiree Shu Hui , Tan Jack Jie En , Tan Sze Huey , Choo Su Pin , Tai David Wai‐Meng , Lee Joycelyn Jie Xin 
Published: August 2022

AbstractIntroductionCombination therapy with immune checkpoint inhibitor (ICI) and antivascular endothelial growth factor (anti‐VEGF) is currently the first line treatment for advanced hepatocellular carcinoma (aHCC). However, there are many patients who may not be able to receive combination therapy due to underlying comorbidities or resource limitations. For these patients, systemic treatment options include single agent tyrosine kinase inhibitors (TKIs) or ICI monotherapy. However, whether an optimal sequence of systemic therapy exists remains unknown. We aim to explore the impact of sequencing of TKI and ICI therapy in terms of response rates and to examine the safety of their use in sequential order.MethodsPatients with aHCC treated with both ICI and TKI between December 30, 2013 and June 13, 2018 were retrospectively identified. Patients were classified into two groups: those who received TKI in the first‐line (TKI1), followed by ICI (ICI2) and those who received ICI (ICI1) in the first‐line followed by TKI (TKI2). The primary objective of the study was to identify differences in objective response rate (ORR) and disease control rate (DCR), as evaluated based on response evaluation criteria in solid tumor v1.1 for TKI1, TKI2, ICI1, and ICI2. Secondary objectives included comparison of progression free survival (PFS) for each line of therapy, overall survival (OS) and adverse events (AEs).ResultsTwenty‐seven and 23 patients were classified into group 1 and 2, respectively. Objective response rates of TKI1 and TKI2 were 3.8% and 17.6%, respectively (p = .28); DCR to TKI1 versus TKI2 was 23.1% versus 35.3% (p = .49). ORRs of ICI1 and ICI2 were 8.7% and 14.3%, respectively (p = .66); DCR to ICI2 versus ICI1 was 56.5% versus 42.9% (p = .37). Median PFS was not significant between TKI1 and TKI2 (PFS 3.06 versus 1.61 months, p = .097) as well as between ICI2 and ICI1 (PFS 1.84 versus 2.37 month, p = .32). Median OS was also not significantly different between both groups (OS 20.63 versus 13.93 months, p = .20) on univariable and multivariable analysis (OS adjusted hazard ratio [HR] 2.07, 95% CI .83–5.18, p = .118). The proportion of patients who experienced adverse events of any grade was similar in both groups (TKI1 59.3% versus TKI2 52.2%; ICI1 78.3% versus ICI2 70.4%).ConclusionOur study suggests that the sequence of TKI versus ICI therapy in patients with aHCC may not matter, given similar efficacy and toxicity profile when either agent is received in the first or second‐line setting. This finding is of value in the real‐world setting, where patients may be frail or have comorbidities that render them unable to tolerate combination therapy (ICI and TKI/anti‐VEGF). For these patients, sequential exposure to both classes of drugs (ICI and TKI) may be a suitable option.
Can magnetic resonance imaging enhance the assessment of potential new treatments for cognitive impairment in mood disorders? A systematic review and position paper by the International Society for Bipolar Disorders Targeting Cognition Task Force
Authors: Miskowiak Kamilla W. , Yalin Nefize , Seeberg Ida , Burdick Katherine E. , Balanzá‐Martínez Vicent , Bonnin Caterina del Mar , Bowie Christopher R. , Carvalho Andre F. , Dols Annemieke , Douglas Katie , Gallagher Peter , Hasler Gregor , Kessing Lars V. , Lafer Beny , Lewandowski Kathryn E. , López‐Jaramillo Carlos , Martinez‐Aran Anabel , McIntyre Roger S. , Porter Richard J. , Purdon Scot E. , Schaffer Ayal , Sumiyoshi Tomiki , Torres Ivan J. , Van Rheenen Tamsyn E. , Yatham Lakshmi N. , Young Allan H. , Vieta Eduard , Stokes Paul R. A. 
Published: August 2022

AbstractBackgroundDeveloping treatments for cognitive impairment is key to improving the functioning of people with mood disorders. Neuroimaging may assist in identifying brain‐based efficacy markers. This systematic review and position paper by the International Society for Bipolar Disorders Targeting Cognition Task Force examines the evidence from neuroimaging studies of pro‐cognitive interventions.MethodsWe included magnetic resonance imaging (MRI) studies of candidate interventions in people with mood disorders or healthy individuals, following the procedures of the Preferred Reporting Items for Systematic reviews and Meta‐Analysis 2020 statement. Searches were conducted on PubMed/MEDLINE, PsycInfo, EMBASE, Cochrane Library, and Clinicaltrials.gov from inception to 30th April 2021. Two independent authors reviewed the studies using the National Heart, Lung, Blood Institutes of Health Quality Assessment Tool for Controlled Intervention Studies and the quality of neuroimaging methodology assessment checklist.ResultsWe identified 26 studies (N = 702). Six investigated cognitive remediation or pharmacological treatments in mood disorders (N = 190). In healthy individuals, 14 studies investigated pharmacological interventions (N = 319), 2 cognitive training (N = 73) and 4 neuromodulatory treatments (N = 120). Methodologies were mostly rated as ‘fair’. 77% of studies investigated effects with task‐based fMRI. Findings varied but most consistently involved treatment‐associated cognitive control network (CCN) activity increases with cognitive improvements, or CCN activity decreases with no cognitive change, and increased functional connectivity. In mood disorders, treatment‐related default mode network suppression occurred.ConclusionsModulation of CCN and DMN activity is a putative efficacy biomarker. Methodological recommendations are to pre‐declare intended analyses and use task‐based fMRI, paradigms probing the CCN, longitudinal assessments, mock scanning, and out‐of‐scanner tests.
Tractable Bayes of Skew-Elliptical Link Models for Correlated Binary Data
Authors: Zhang Zhongwei , Arellano-Valle Reinaldo B. , Genton Marc G. , Huser Raphaël 
Published: August 2022

Abstract
Correlated binary response data with covariates are ubiquitous in longitudinal or spatial studies. Among the existing statistical models, the most well-known one for this type of data is the multivariate probit model, which uses a Gaussian link to model dependence at the latent level. However, a symmetric link may not be appropriate if the data are highly imbalanced. Here, we propose a multivariate skew-elliptical link model for correlated binary responses, which includes the multivariate probit model as a special case. Furthermore, we perform Bayesian inference for this new model and prove that the regression coefficients have a closed-form unified skew-elliptical posterior with an elliptical prior. The new methodology is illustrated by an application to COVID-19 data from three different counties of the state of California, USA. By jointly modeling extreme spikes in weekly new cases, our results show that the spatial dependence cannot be neglected. Furthermore, the results also show that the skewed latent structure of our proposed model improves the flexibility of the multivariate probit model and provides a better fit to our highly imbalanced dataset.
Impacts of abiotic and biotic factors on terrestrial leeches in Indonesian Borneo
Authors: Nelaballi Swapna , Finkel Benjamin J. , Bernard Andrew B. , Estrada Gene R. , Setiawan Endro , Setia Tatang Mitra , Susanto Tri Wahyu , Rhanda Raden , Surya  , Jakaria  , Andika Dika , Lemoine Sylvain , Jaffe Sarah M. , Barrow Elizabeth J. , Justinek Živa , Wittmer Heiko U. , Marshall Andrew J. 
Published: August 2022

AbstractHaemadipsid leeches are ubiquitous inhabitants of tropical and sub‐tropical forests in the Indo‐Pacific region. They are increasingly used as indicator taxa for biomonitoring, yet very little is known about their basic ecology. For example, to date no study has assessed the occurrence and distribution of haemadipsid leeches across naturally occurring gradients within intact habitats. We analyzed a long‐term data set (2012–2020) on the closely related tiger (Haemadipsa picta) and brown (Haemadipsa spp.) leech species to investigate if and how abiotic and biotic factors influence their occurrence across a gradient of forest types at an undisturbed tropical rainforest site in Indonesian Borneo. We compared a series of negative binomial mixed models and found that, of the abiotic factors, soil moisture had the largest positive effect on encounter rates of both leech species. Among biotic factors, forest type had differential effects on counts of the two species: while tiger leech counts were greater in low elevation forest types, brown leech counts were greater in high elevation forest types. Additionally, we found that the presence of one species had a positive effect on the presence of the other species. Finally, our results show that the tiger leech has a narrower distribution, being restricted to lower elevation forest types with higher water retention, suggesting that the tiger leech could be more sensitive to lower soil moisture levels.Abstract in Indonesian is available with online material.
Rapid generation of genetically engineered T cells for the treatment of virus‐related cancers
Authors: Jiang Jinxing , Xia Ming , Zhang Lijie , Chen Xi , Zhao Yue , Zeng Chenquan , Yang Haiyan , Liang Peng , Li Guanghe , Li Ning , Qi Hui , Wei Teng , Ren Lili 
Published: August 2022

AbstractAdoptive transfer of T cell receptor (TCR)‐engineered T cells targeting viral epitopes represents a promising approach for treating virus‐related cancers. However, the efficient identification of epitopes for T cells and the corresponding TCR remains challenging. Here, we report a workflow permitting the rapid generation of human papillomavirus (HPV)‐specific TCR‐T cells. Six epitopes of viral proteins belonged to HPV16 or HPV18 were predicted to have high affinity to A11:01 according to bioinformatic analysis. Subsequently, CTL induction were performed with these six antigen peptides separately, and antigen‐specific T cells were sorted by FACS. TCR clonotypes of these virus‐specific T cells were determined using next‐generation sequencing. To improve the efficiency of TCRαβ pair validation, a lentiviral vector library containing 116 TCR constructs was generated that consisted of predominant TCRs according to TCR repertoire analysis. Later, TCR library transduced T cells were simulated with peptide pool‐pulsed antigen‐presenting cells, then CD137‐positive cells were sorted and subjected to TCR repertoire analysis. The top‐hit TCRs and corresponding antigen peptides were deduced and validated. Through this workflow, a TCR targeting the E692–101 of HPV16 was identified. These HPV16‐specific TCR‐T cells showed high activity towards HPV16‐positive human cervical cancer cells in vitro and efficiently repressed tumor growth in a murine model. This study provides a HPV16‐specific TCR fitted to the HLA‐A11:01 population, and exemplifies an efficient approach that can be applied in large‐scale screening of virus‐specific TCRs, further encouraging researchers to exploit the therapeutic potential of the TCR‐T cell technique in treating virus‐related cancers.
A Glance into Public Memory: Which Public? Whose Memory? The Demise of Red Location Cultural Precinct
Authors: Kadi Palesa 
Published: August 2022

AbstractIn 2021, the international award‐winning South African Red Location Museum (RLM), situated within the Red Location Cultural Precinct and termed a ‘national site of struggle’ by Noero Wolff Architects, remains derelict. This paper is about the continuing narrative of state‐built infrastructure being held hostage to community protests. It focuses on the museum and its depiction of the public/s that made Red Location. The intensity of community protest has had a significant impact on the Red Location Cultural Precinct with the museum's closure in 2013. As I shall argue in the paper, more attention should be paid to the questions of museum public/s and whose memory heritage projects intend to document. Furthermore, the place of cultural institutions such as township museums requires a review of the idea itself. Given this context, I discuss two intertwined narratives, one, the concept of the promise of infrastructure, and the second, the impact of politics on heritage.
MOHOA Considering the Curious Case of the Satyagraha House, Johannesburg. A Curatorial Critique
Authors: McKay Harriet 
Published: August 2022

AbstractWhat can the case of Satyagraha House, the luxury guesthouse and museum complex established on the site of a domestic building briefly inhabited by Mohandas Gandhi from 1908 to 1909, suggest about the complexities attached to heritage and preservation in the contemporary South African context? What can this hybrid museum and guesthouse space offer to advance dialogue around the heritage of modern Africa, which will allow alternatives to the ‘traditional’ museum to emerge? Equally, when innovative modes of presenting heritage arise as a result of initiatives from outside the country, the need to pay due diligence to local memory and understanding is considered here as being of paramount importance. Failure to do this, as, I argue, has inadvertently taken place at Satyagraha House, will place modern museum practice in South Africa as belonging to the past rather than to the present and future of modern African heritage.
The Modern Architecture of Arieh Sharon's Obafemi Awolowo University Campus, Ile‐Ife, Nigeria
Authors: Jaiyeoba Emmanuel Babatunde , Efrat Zvi 
Published: August 2022

AbstractThe Obafemi Awolowo University (formerly the University of Ife) campus in Nigeria is one of the identifiable modern heritage sites of Africa. It is significant to the history of tertiary education and the political history of Nigeria and especially to the global history of modern architecture as an exemplar of buildings shorn of ornamental colonial ostentation, emphasizing lightness and green vegetation and aspirational for the newly independent African states. Its manifestation is often labeled “tropical architecture”, interpreted as the adaptation of modern architecture to the tropical climate. This paper presents an argument for the importance of this work to Modern Heritage of Africa.
Housing trajectories and the risk of homelessness among new mental health service users: Protocol for the AMONT study
Authors: Roy Laurence , Abdel‐Baki Amal , Bérubé Félix‐Antoine , Crocker Anne , de Benedictis Luigi , Dostie Mathieu , Latimer Eric , Roy Marc‐André 
Published: August 2022

AbstractAimsHigh rates of mental illness among individuals experiencing homelessness, as well as documented contacts with psychiatric services prior to episodes of homelessness, indicate that early intervention could play a key role in homelessness prevention. Decision‐makers and clinical teams need longitudinal data on housing trajectories following initial contact with psychiatric services, as well as on predictors of risk of housing instability and homelessness. This paper describes the AMONT study, a mixed‐methods naturalistic longitudinal cohort study of individuals identified as new psychiatric service users in seven clinical sites across the province of Québec (Canada).MethodsThe goal of AMONT is to examine the housing situations of individuals over 36 months after their initial contact with psychiatric services, and to identify environmental and individual correlates and predictors of housing outcomes. Participants complete a broad battery of instruments at baseline and follow‐up assessments after 24 and 36 months. We explore housing stability following an initial episode of psychiatric service use from the perspective of service users, family members, and service providers, through qualitative interviews.Results and ConclusionsThe findings from the AMONT study will yield a better understanding of the residential pathways of individuals with mental illness, from their first contact with psychiatric services and for 3 years subsequently. This will inform service providers, decision‐makers and managers on the specific housing concerns and issues that affect first‐time mental health service users. This in turn can lead to the development and implementation of evidence‐informed practices and policies that aim to prevent instability and homelessness.
Gendering of care and care inequalities in couple therapy
Authors: Smoliak Olga , Rice Carla , LaMarre Andrea , Tseliou Eleftheria , LeCouteur Amanda , Davies Adam 
Published: August 2022

AbstractReciprocal partner or spousal caregiving in romantic relationships has been identified as a key determinant of the quality of couple relationships. In this article, we interrogate this premise concerning the presumed reciprocity of caregiving in romantic relationships, focusing on cisgender heterosexual relationships and offering implications for relationships of all genders and sexualities. Looking beyond the conventional focus on individual or dyadic processes, we theorize imbalances in care as gendered. Feminists have repeatedly critiqued gender ideology that devalues caring labor and allocates it to women. Gendered power dynamics can lead to imbalances in care‐seeking and care provision. We discuss how the gendering of care and care inequalities can manifest in couple therapy, illustrating with examples from recorded interactions. Implications for therapy practice are discussed.
An evaluation of the quality of COVID‐19 websites in terms of HON principles and using DISCERN tool
Authors: Safdari Reza , Gholamzadeh Marsa , Saeedi Soheila , Tanhapour Mozhgan , Rezayi Sorayya 
Published: August 2022

AbstractBackgroundAs many people relied on information from the Internet for official scientific or academically affiliated information during the COVID‐19 pandemic, the quality of information on those websites should be good.ObjectiveThe main purpose of this study was to evaluate a selection of COVID‐19‐related websites for the quality of health information provided.MethodUsing Google and Yahoo, 36 English language websites were selected, in accordance with the inclusion criteria. The two tools were selected for evaluation were the Health on the Net (HON) Code and the 16‐item DISCERN tool.ResultsMost websites (39%) were related to information for the public, and a small number of them (3%) concerned screening websites in which people could be informed of their possible condition by entering their symptoms. The result of the evaluation by the HON tool showed that most websites were reliable (53%), and 44% of them were very reliable. Based on the assessment results of the Likert‐based 16‐item DISCERN tool, the maximum and minimum values for the average scores of each website were calculated as 2.44 and 4.25, respectively.ConclusionEvaluation using two widely accepted tools shows that most websites related to COVID‐19 are reliable and useful for physicians, researchers and the public.
Family structure in relation to body mass index and metabolic score in European children and adolescents
Authors: Stahlmann Katharina , Lissner Lauren , Bogl Leonie H. , Mehlig Kirsten , Kaprio Jaakko , Klosowska Joanna C. , Moreno Luis A. , Veidebaum Toomas , Solea Antonia , Molnár Dénes , Lauria Fabio , Börnhorst Claudia , Wolters Maike , Hebestreit Antje , Hunsberger Monica ,   IDEFICS/I.Family consortia
Published: August 2022

SummaryBackgroundLiving in single parent and blended families or as an only child—compared to living in two‐parent biological families or with siblings, respectively—is associated with a higher body mass index (BMI) in cross‐sectional studies. However, longitudinal research addressing the children's BMI in this context is scarce. Further, little is known about the association between family structure and metabolic health.ObjectivesThis study aimed at investigating the association between both aspects of family structure with BMI and a metabolic score (MetS).MethodsCross‐sectional data from 7804 children participating in the European multi‐center I.Family study (2013/2014) and longitudinal data from 5621 children who also participated previously in the IDEFICS study (2007–2010) were used. Family structure was assessed by a detailed interview. BMI z‐score and the MetS were based on measured anthropometry, blood pressure, high‐density lipoprotein, blood glucose, and triglycerides. Linear regressions were performed to model associations between family structure with BMI and MetS.ResultsChildren from single‐parent families had higher BMI z‐scores in the cross‐sectional (β = 0.09, 95% confidence interval [CI]: 0.001 to 0.18) and longitudinal analyses compared to those from two‐parent families. Cross‐sectionally, the number of siblings was associated with lower BMI z‐scores (β = −0.07, 95% CI: −0.10 to −0.03) and lower MetS (β = −0.14, 95% CI: −0.26 to −0.01). Longitudinally, only children between baseline and follow‐up had higher BMI z‐scores at follow‐up (β = 0.07, 95% CI: 0.01 to 0.14) compared to stable siblings.ConclusionObesity prevention measures should focus on single‐parent households and families with an only child.