bluuebunny/crossref_metadata_2025_split huggingface dataset:
An improved teaching-learning-based optimization with multi-learning strategy and ranking-based selection for multitask optimization problems
Authors: Guo Wei , Zou Feng , Chen Debao 
Published: June 2022

Abstract
In recent years, evolutionary multitask optimization (EMTO) has gained enough attention in the research community. Multitask optimization (MTO) makes full use of the potential parallelism of population search-based efforts to achieve cross-domain optimization of multiple optimization problems and make knowledge migration between different optimization problems possible. Whether from the angle of convergence speed or quality, it shows better ability than single task optimization. However, we note that the current EMTO algorithm uses only a single crossover for knowledge transfer, which can’t reduce the impact of negative information in the process of knowledge transfer. There are some limitations in solving available tasks. This paper presents a new multitask teaching-learning-based optimization with multi-learning strategies and ranking-based selection strategy (MTTLBO-MR). In the teaching stage, there are three learning strategies for students to choose. In the learning stage, each student chooses the learning strategy from two strategies according to their own situation. Different from the greedy selection strategy of the original TLBO, the new offspring is selected on the basis of the rank based on the factorial rank and diversity rank of each individual. The test result states clearly that MTTLBO-MR updates knowledge through suitable learning strategies at different optimization stages and has outstanding performance on dealing with multitask optimization tasks.
Wideband Polarization-insensitive Metamaterial Microwave Absorber for S and C Band Application
Authors: Barde Chetan , Ranjan Prakash , Choubey Arvind , Sinha Rashmi , Das Debolina , Roy Komal 
Published: June 2022

Abstract
The designing and development of wideband polarization insensitive Metamaterial Microwave Absorber (MMA) is presented in this paper. The proposed unit cell consists of four trapezoidal which is connected to concentric square and cantered square via lumped resistors. The absorber is designed on FR-4 substrate with permittivity 4.3 and thickness 0.256 mm (λ/144). The wideband absorptivity with more than 90 % absorption is obtained from 2.21 GHz to 6.61 GHz having bandwidth of 4.40 GHz. Two distinct absorptivity peaks have been perceived in the range of interest having frequencies at 2.49 GHz and 5.68 GHz with maximum magnitude of 92.50% and 92.14%. The designed absorber is also found to be polarisation insensitive for both TE and TM polarised Electromagnetic (EM) wave up to oblique incidence of about 60°. These two peaks arise because of plasmonic resonance. The fabricated structure is measured inside the Anechoic Chamber, the simulated and measured results are almost similar to each. The proposed absorber structure finds applications for S (2-4 GHz) and C (4-8 GHz) band particularly in defence applications for wideband stealth applications and RCS reductions.
Hydrogen gas treatment improves postoperative delirium and cognitive dysfunction in elderly noncardiac patients
Authors: Lin Hua , Du Jian , Su Yanchao , Tian Zhigang , Yu Yonghao , Cui Yan , Xie Ke-liang 
Published: June 2022

Abstract
Background: Postoperative delirium, a common complication after surgery in elderly individuals, is a state of acute brain dysfunction characterized by fluctuating mental status that affects millions of patients each year. We used prophylactic inhalation of hydrogen gas with elderly patients undergoing elective surgery to compare their occurrence of postoperative delirium with that of controls.Methods: A total of 184 patients were enrolled and randomized into a control group and a hydrogen inhalation group. All the patients were >= 65 years of age. The quality of sleep was assessed 1 day before surgery and 1, 3, and 7 days after surgery at 8 AM. The Confusion Assessment Method (CAM) was used as a screening tool for delirium. The patients' postoperative state of consciousness was assessed using the CAM 1-7 days after surgery. If delirium was diagnosed, the time of onset and duration of delirium were recorded.Results: Postoperative delirium happened in 17 (24%) of 70 elderly noncardiac patients and in 10 (12%) of 83 patients after hydrogen inhalation. The incidence of delirium was decreased in the hydrogen group. No significance differences were found in length of stay in the hospital after surgery between the two groups. For additional outcomes, there was no significant difference in sleep quality between the two groups at 1, 3, and 7 days postoperatively, and the sleep quality gradually recovered over 7 days postoperatively. The numerical rating scale (NRS) pain scores were higher in the hydrogen group (4.08±1.77) than in the control group (3.54±1.77) on day 1 (P<0.05); however, the mean difference in NRS pain scores between the two groups was small (1 to 1.6). There was no significant difference on day 3 or 7. The postoperative C-reactive protein level was significantly lower in the hydrogen group than in the control group.Conclusions: This study suggests that hydrogen inhalation can prevent postoperative delirium in elderly noncardiac patients by reducing the inflammatory response.
Approximately Local Derivations on $\ell^{1}$-Munn algebras with applications to Semigroup Algebras
Authors: Essmaili Morteza , Vahdati Hatam , Alinejad Ahmad 
Published: June 2022

Abstract
At the present paper, we investigate bounded approximately local derivations of ℓ1-Munn algebra MI (A); where I is an arbitrary non-empty set and A is an approximately locally unital Banach algebra. Indeed, we show that if AB(A,A*) and BA(A,A*) are reflexive, then bounded approximately local derivations from MI (A) into any Banach MI (A)-bimodule X are derivations. Finally, we apply this result to study bounded approximately local derivations of the semigroup algebra ℓ1(S); where S is a uniformly locally finite inverse semigroup.
Genetic characteristics of platinum-sensitive ovarian clear cell carcinoma
Authors: Saito Ryosuke , Kuroda Takafumi , Yoshida Hiroshi , Sudo Kazuki , Saito Motoaki , Tanabe Hiroshi , Takano Hirokuni , Yamada Kyosuke , Kiyokawa Takako , Yonemori Kan , Kato Tomoyasu , Okamoto Aikou , Kohno Takashi 
Published: June 2022

Abstract
BackgroundMost ovarian clear cell carcinomas (OCCCs) are resistant to platinum-based chemotherapy, while a small subset shows a positive response. The aim of this study was to clarify the clinical, pathological, and genetic characteristics of platinum-sensitive OCCCs.MethodsThe study included 53 patients with stage III–IV OCCC who had residual tumors after primary surgery and received platinum-based therapy between 2009 and 2018. A retrospective examination of platinum sensitivity was performed using the criterion of ≥6 months from the last day of first-line platinum therapy until recurrence/progression. Cases determined to be platinum-sensitive were subjected to immunohistochemical staining, genomic analyses using target sequencing (i.e., NCC Oncopanel) and homologous recombination deficiency (HRD) (myChoice® HRD Plus) assays. ResultsOf the 53 stage III–IV OCCC cases, 11 (21%) were platinum-sensitive. These cases showed better progression-free and overall survival than platinum-resistant cases (hazard ratio = 0.16, P < 0.001). Among the seven sensitive cases whose tumor tissues were available for molecular profiling, five were pure OCCC based on pathological and genetic features, whereas the remaining two cases were re-diagnosed as HGSOC (high-grade serous ovarian carcinoma). The pure OCCCs lacked BRCA1 and BRCA2 mutations, consistent with the absence of the HRD phenotype, whereas two cases (40%) had ATM mutations. By contrast, the two HGSOC cases had BRCA1 or BRCA2 mutations associated with the HRD phenotype. ConclusionsThe subset of platinum-sensitive OCCCs includes a majority with pure OCCC features that lack the HRD phenotype.
The difference in the surface coverage ratio by an adapted hand rubbing technique and the WHO technique; a randomized group comparison
Authors: Suzuki Yumi , Morino Motoko , Morita Ichizo , Ohiro Sumie 
Published: June 2022

Abstract
Background
The adapted 6-step without interlock (A6Sw/oI) hand rub technique, commonly practised in Japan, adds the “wrist” but omits the “interlock” step compared to the WHO 6-step technique (WHO6S). The first objective of this study was to assess the differences in the efficacy of the two techniques regarding surface coverage, considering hand size. The second objective was to analyse the coverage differences between hand sizes.
Methods
Participants were randomly assigned to either one of the WHO6S or the A6Sw/oI. The coverage ratios of the anatomically divided sections of the hands were evaluated by a digital device using artificial intelligence technology.
Results
The mean dorsum coverage by WHO6S and A6Sw/oI was 90.6% vs 88.4% (p < 0.01), and the ratio of the participants with insufficient coverage of the dorsum of the four fingers was 0.0%-7.4% vs 28.2–51.4% (p < 0.001). Dorsum coverage varied largely between hand size for both techniques, and significant differences were found between small and large hands.
Discussion and Conclusion
The WHO6S was superior to the locally adapted technique regarding hand surface coverage. Hand size should be considered when assessing coverage differences between procedures.
Flavokawain B inhibits the growth and metastasis of hepatocellular carcinoma through the suppression of UCK2 mediated downregulation of STAT3/Hif-1α/VEGF signalling pathway
Authors: Malami Ibrahim , Alhasan Alhasan Muhammad , Adamu Adamu Ahmed , Bello Muhammad Bashir , Muhammad Aliyu , Imam Mustapha Umar 
Published: June 2022

Abstract
This study investigates the effects of Flavokawain B (FKB) on the growth and development of metastatic hepatocellular carcinoma. HepG2 cells were used in this study and a neutral red assay was performed to determine the anti-proliferation effects of FKB at varying concentrations. Cell scratch and exclusion zone assays were performed to assess the inhibitory effects of FKB on the cell migration and invasion and relative mRNA levels were quantified using the RT-qPCR. FKB inhibited the proliferation of HepG2 cells at an IC50 value of 28 µM, which conforms to its apoptosis-inducing effects. Cell migration and invasion were significantly inhibited at 7, 14 and 28 µM of FBK. UCK2 expression was significantly downregulated after FKB treatments. Inhibition of STAT3 expression subsequently induced the downregulation of VEGF and HIF-1α expressions. Our data suggest that FKB inhibits HepG2 proliferation and suppresses its metastasis abilities, thus providing a potential alternative and viable strategy against HCC.
Failed insertion of ureteral access sheath during flexible ureterorenoscopy: A randomized controlled trial comparing second session flexible ureterorenoscopy or same session mini percutaneous nephrolithotomy
Authors: Caglar Ufuk , Erbin Akif , Ucpinar Burak , Ayranci Ali , Sarilar Omer , Yanaral Fatih , Baykal Murat , Ozgor Faruk , Akbulut Fatih 
Published: June 2022

Abstract
We aimed to compare different treatment approaches in patients with failed ureteral access sheath placement during first flexible ureterorenoscopy (f-URS) session. Patients with kidney stones measuring 1-2 cm, presented to our urology clinic between April 2019 and April 2021, were included in the study for evaluation. Patients were randomized into two groups, in case of a failed ureteral access sheath placement during the first f-URS session. In group 1, ureteral JJ stent was placed for dilation and second session of f-URS was planned 4-6 weeks later. In group 2, mini percutaneous nephrolithotomy (mPNL) was performed in the same session. Pre-operative demographic data, operative and post-operative characteristics including complications and success rates were compared. Patients were assessed by Short-Form-36 (SF-36) questionnaires to compare overall life quality after each procedure. Twenty-four patients were included in each group. Pre-operative demographic data and stone characteristics of the patients in each group were comparable. Operation time, fluoroscopy time, and hospital stay were significantly higher in the mini-PNL group (p:0.001, p:0.001 and p:0.001, respectively). When SF-36 values were compared, physical function, pain, role limitation, and general health value scores were improved in both groups after treatment. The improvement in physical function and pain parameters was statistically significant in the mPNL group (p:0.026 and p:0.017).In patients with failed ureteral access sheath placement, placing a JJ stent for dilation and postponing f-URS for 4-6 weeks provides the advantages of low hospitalization time for each admission, shorter fluoroscopy and operation time. Performing mPNL in the same session, results in better improvements in SF-36 parameters such as pain and physical function compared to f-URS. The success and complication rates of the two procedures were comparable.
Influence Maximization using Community Detection aided with Adaptive β Coral Reefs Optimization
Authors: Ahmed Shameem , Maulik Ujjwal 
Published: June 2022

Abstract
The purpose of influence maximization in a cascade model is to extricate a group of hubs from underlying network that can maximize propagation. Greedy methods may be used to perform influence maximization. However, as it has ahigh computational cost, it becomes inefficient. Centrality-based heuristic methods can be considered as a replacement. But it gets trapped in local optima. To address these issues, a framework has been introduced which uses community detection, tries to find the most significant nodes from each community using closeness centrality. Then, it employs Coral Reefs Optimization to determine the best solutions, i.e., the most important nodes that maximize propagation. Adaptive β-Hill Climbing has been used. It acts as a local search to avoid getting caught in local optima. A few datasets were used to evaluate the proposed framework’ scalabilities. Moreover, the outcomes were compared to several state-of-the-art techniques based on 2-hop influence spread and Monte-Carlo simulations.
Prognostic significance of high-level PIM1 and is related to tumor microenvironment in Low-grade Glioma
Authors: Chen Fan , Huang Tao , Zhong Ying , Xie Xuan , Wang Liang 
Published: June 2022

Abstract
PIM1 has been shown to be associated with the development of multiple human cancers, but the biological mechanisms of PIM1 in glioma development, particularly the role of TME immune cell infiltration, remain unclear. We analyzed clinical information and gene expression data of all glioma samples and evaluated the relationship with overall survival by univariate and multivariate Cox regression. We also analyzed genes and downstream signaling pathways associated with PIM1 by gene set enrichment analysis. And we analyzed characterized oncogenic pathways, biological pathways, and TME immune cell infiltration in glioma samples with different PIM1 expressions, and validated it by in vitro experiments. The results of Cox regression analysis confirmed that overexpression of PIM1 was significantly associated with malignant progression and poorer survival of gliomas. Using PIM1 and other clinical features, we successfully constructed a nomogram to predict the prognosis of glioma, and Gene Set Enrichment Analysis revealed the association between PIM1 overexpression with cell cycle, cAMP signaling pathway, et al. Meanwhile, overexpression of PIM1 was significantly associated with increased expression of many immune checkpoints and immune cell infiltration. In conclusion, our study confirmed that overexpression of PIM1 is a potential molecular marker of poor prognosis in glioma and that PIM1 plays an important role in TME immune cell infiltration. By identifying PIM1-regulated signaling pathways and immune checkpoints enhances our understanding of the TME immune cell infiltration characteristics of glioma and contributes to the development of immunotherapeutic strategies.
A Secure and Robust Trust-Based Task Allocation Model for Batch-of-Tasks (BoT) in Cloud Computing
Authors: Haidri Raza Abbas , Alam Mahfooz , Mahak - , Shahid Mohammad , Prakash Shiv 
Published: June 2022

Abstract
Security is emerging as an essential issue in the design of infrastructure-as-a-service (IaaS) cloud environment applications, which are broadly used in micro-system reliability, transaction processing system, e-commerce services, digital computers for government and medical electronics. Here, the security-driven allocation of Batch of Tasks (BoT) in cloud system is a challenging issue and has been reported as a well-known NP-complete problem. So, many models have been developed, however, existing trust-based models do not factor in security demand properly when making the decision and assigning the cloudlets/tasks. To design a trust-based task allocation model, evaluation and computation of security overhead are needed. The proposed model is negotiating the cipher suite between the task and computing resource in the form of security demand. Furthermore, this paper proposes Security Aware Efficient Static Task Allocation (SA-ESTA) and Security Prioritized Efficient Static Task Allocation (SP-ESTA) algorithms which integrate security demands and trust level into allocation for the IaaS Cloud environment. The proposed algorithms schedule a BoT, on virtual machines (VMs) in order to optimize the flowtime, security overhead, and system failure probability. To evaluate the performance of SA-ESTA and SP-ESTA, the experimental study based on random test-bed trace has been conducted and compared with four other existing baselines and three traditional algorithms on account of flowtime, security overhead and failure probability. Our meticulous performance simulation results clearly show that the proposed algorithms perform better than the peer algorithms under various test conditions.
The Bayesian approach to analysis of financial operational risk
Authors: Levenchuk Liudmyla 
Published: June 2022

The article provides a short overview of methods for constructing mathematical models in the form of Bayesian Networks for modeling operational risks under conditions of uncertainty. Let’s provide the sequence of actions necessary for creating a model in the form of the network, methods for computing a probabilistic output in BN, and give examples of using the tool to solve practical problems of operational financial risk estimation. The study results can be used by financial institutions as a tool for resolving specific practical issues of risk estimation.
The object of research: methods for constructing Bayesian Networks for modeling operational risk in financial institutions.
Investigated problem: modeling operational risk under conditions of uncertainty.
The main scientific results: overview of methods for constructing Bayesian Networks for modeling operational risk under conditions of uncertainty; the methodology in the form of sequence of actions necessary for creating the model in the form of the network; methods for computing a probabilistic output in BN; examples of applying such approaches to solve practical problems of operational financial risk estimation.
The area of practical use of the research results: The research results can be used in the following financial institutions: banking system, insurance and investment companies.
Innovative technological product: computer based decision support system, allowing for high quality modeling and estimation of operational risks.
Scope of the innovative technological product: the practice of usage the proposed models in financial organizations provides an evidence of their high efficiency in terms of formal description and estimation of operational risk
Aminopeptidases in Cancer, Biology and Prospects for Pharmacological
Intervention
Authors: Lehmann Fredrik , Holstein Sarah A. , Heckman Caroline A. , Davies Faith E. , Morgan Gareth J. , Gelius Stefan Svensson 
Published: June 2022

Abstract:
Aminopeptidases, which catalyze the cleavage of amino acids from the amino terminus of
proteins, are widely distributed in the natural world and play a crucial role in cellular processes and
functions, including metabolism, signaling, angiogenesis, and immunology. They are also involved
in the homeostasis of amino acids and proteins that are required for cellular proliferation. Tumor
cells are highly dependent on the exogenous supply of amino acids for their survival, and overexpression
of aminopeptidase facilitates rapid tumor cell proliferation. In addition, clinical studies have
demonstrated that patients with cancers with high aminopeptidase expression often have poorer outcomes.
Emerging evidence supports the rationale of inhibiting aminopeptidase activity as a targeted
approach for novel treatment options, as limiting the availability of amino acids can be selectively lethal
to tumor cells. While there are agents that directly target aminopeptidases that demonstrate potential
as cancer therapies, such as bestatin and tosedostat, more selective and more targeted therapeutic
approaches are needed. This article specifically looks at the biological role of aminopeptidases
in both normal and cancer processes, and their potential as a biological target for future therapeutic
strategies.
When examining previous publications, most do not cover aminopeptidases and their role in cancer
processes. Aminopeptidases play a vital role in cell processes and functions; however, their overexpression
may lead to a rapid proliferation of tumor cells. Emerging evidence supports the rationale of
leveraging aminopeptidase activity as a targeted approach for new oncological treatments. This article
specifically looks at the biological role of aminopeptidases in both normal and cancer processes,
and their potential as a biological target for future therapeutic strategies.
Association of Inflammatory Biomarkers and Cardiovascular Risk Scores
in an Italian Cohort of HIV Positive Patient Undergoing Antiretroviral
Therapy
Authors: Katia Falasca , Claudio Ucciferri , Antonio Auricchio , Marcella Reale , Erica Costantini , Jacopo Vecchiet 
Published: June 2022

Background:
Several algorithms have been developed to predict cardiovascular risk (CVR) over time, however none of them seem to be accurate when applied to HIV patients.

Objective:
The aim of this study was to assess plasma inflammatory biomarkers in relation to multiple CVR scores (FRS, ASCVD, PROCAM and the DAD-5 Years-Estimated-Risk) in an Italian cohort of HIV patients undergoing a combined Antiretroviral Therapy (cART).

Methods:
We enrolled HIV patients undergoing cART without any change in the HIV-related pharmacological therapy over the last 48 weeks Demographic and anamnestic data were collected, and a biochemical panel including the following biomarkers was collected: CRP, Cystatin-C, microalbuminuria, IL-18, IL-2, IL-4, IL-6, IL-10, TNF-α and IFN- γ. CVR scores were obtained for each patient and compared to the biochemical panel to assess statistical correlation.

Results:
90 Caucasian HIV patients were enrolled. Assessment of CVR scores showed FRS values of 6.98±6.11%, ASCVD 7.18±6.25%, PROCAM 6.7±7.4% and DAD-5 Years Estimated Risk 3.10±3.41%. We found correlations between the levels of circulating cytokines measured and the cardiovascular risk prediction scores.

Conclusions:
Our data showed that the values of selected inflammatory biomarkers strongly correlate with the CVR scores, suggesting that they can be employed as reliable predictors of cardiovascular disease in HIV patients. The routine use of selected biomarkers associated with systemic inflammation could be a valid and readily available tool for clinicians to assess and monitor cardiovascular risk in HIV patients.