bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dissociative Model in Patients With Resistant Schizophrenia
Authors: Panov Georgi 
Published: February 2022

BackgroundSchizophrenia is a severe mental illness in which, despite the growing number of antipsychotics from 30 to 50% of patients remain resistant to treatment. Many resistance factors have been identified. Dissociation as a clinical phenomenon is associated with a loss of integrity between memories and perceptions of reality. Dissociative symptoms have also been found in patients with schizophrenia of varying severity. The established dispersion of the degree of dissociation in patients with schizophrenia gave us reason to look for the connection between the degree of dissociation and resistance to therapy.MethodsThe type of study is correlation analysis. 106 patients with schizophrenia were evaluated. Of these, 45 with resistant schizophrenia and 60 with clinical remission. The Positive and Negative Syndrome Scale (PANSS) and Brief Psychiatric Rating Scale (BPRS) scales were used to assess clinical symptoms. The assessment of dissociative symptoms was made with the scale for dissociative experiences (DES). Statistical methods were used to analyze the differences in results between the two groups of patients.ResultsPatients with resistant schizophrenia have a higher level of dissociation than patients in remission. This difference is significant and demonstrative with more than twice the level of dissociation in patients with resistant schizophrenia.The level of dissociation measured in patients with resistant schizophrenia is as high as the points on the DES in dissociative personality disorder.ConclusionPatients with resistant schizophrenia have a much higher level of dissociation than patients in clinical remission. The established difference between the two groups support to assume that resistance to the administered antipsychotics is associated with the presence of high dissociation in the group of resistant patients. These results give us explanation to think about therapeutic options outside the field of antipsychotic drugs as well as to consider different strategies earlier in the diagnostic process.
Influence of Demographic Factors on Long-Term Trends of Premature Mortality and Burden Due to Liver Cancer: Findings From a Population-Based Study in Shanghai, China, 1973–2019
Authors: Luo Zheng , Zou Yongbin , Xie Jiaxin , Cao Hui , Chen Yichen , Ding Yibo , Li Xiaopan , Deng Yang , Wu Lile 
Published: February 2022

ObjectiveLiver cancer is one of the most common causes of cancer-related death. Understanding how demographic factors influence mortality due to liver cancer is crucial for optimizing disease-control strategies. We aimed to characterize the long-term trends in the mortality and years of life lost (YLL) of liver cancer in Shanghai, China, 1973–2019, and quantitatively analyze the contributions of demographic and non-demographic factors on the mortality of liver cancer.MethodsUsing mortality data from the Mortality Registration System of Pudong New Area, the largest district of Shanghai with a population of permanent resident of 5.68 million, during 1973–2019, we analyzed the temporal trends for the mortality rates and YLL by Joinpoint Regression Program. The difference decomposition method was employed to estimate the increasing mortality rates related to demographic and non-demographic factors.ResultsA total of 21,530 deaths from liver cancer occurred from 1973 to 2019. The crude mortality rates (CMR) and age-standardized mortality rate by Segi's world standard population (ASMRW) of liver cancer were 26.73/105 person-years and 15.72/105 person-years, respectively. The CMR, ASMRW, and YLL rates of liver cancer showed significantly decreasing trends in males, females and the total population from 1973 to 2019, whereas the upward trends in the YLL were seen in males, females and the total population (all P &lt; 0.05). A significant upward trend was observed in the increased CMR caused by demographic factors, but the changing rate caused by non-demographic factors decreased.ConclusionsThe CMR and ASMRW of liver cancer continually decreased although YLL increased during 1973–2019 in Pudong New Area, Shanghai. The demographic factors, especially aging, might be responsible for the increase in the mortality of liver cancer. More effective prevention strategies tailored to liver cancer are needed to further reduce its disease burden in the elderly population.
Identifying Barriers and Facilitators to the Improvement of Healthcare Delivery and Ethics in Two Cameroonian Neurosurgical Centers
Authors: Ankeambom Tutuwan J. , Motah Mathieu , Ewane Mfouapon , Shlobin Nathan A. , Mbangtang Celestin Bilong , Dada Olaoluwa Ezekiel , Kabulo Kantenga Dieu Merci , Tetinou Francklin , Endalle Geneviève , Kanmounye Ulrick Sidney , Jokonya Luxwell , Esene Ignatius N. 
Published: February 2022

BackgroundLow-and middle-income countries (LMICs) are disproportionately affected by neurosurgical burden of disease. This health inequity causes constraints in decision-making. Neurosurgical ethics helps us to assess the moral acceptability and effectiveness of clinical decisions. We aimed to assess ethical neurosurgical care and its effect on patient satisfaction in Cameroon.MethodsTwo questionnaires hosted on Google Forms were administered among inpatients and staff at two Cameroonian neurosurgery centers. The questionnaires covered the factors influencing health outcomes and ethics. Data were collected from November 11, 2020, to March 11, 2021 and analyzed with SPSS v 26 to generate non-parametric tests with a threshold of significance at 0.05.ResultsSeventy patients and twenty healthcare providers responded to the survey. Most patients faced financial hardship (57.1%; 95% CI = 45.7–68.6%), and felt that this affected the care they received (P= 0.02). Patients noticed changes in the care plan and care delivery attributable to the neurosurgical units' lack of resources. According to the patients and caregivers, these changes happened 31.0–50.0% of the time (42.9%, 95% CI = 5.7–21.4%). The majority of patients were pleased with their involvement in the decision-making process (58.6%; 95% CI = 47.1–70.0%) and felt their autonomy was respected (87.1%; 95% CI = 78.6–94.3%).ConclusionMultiple challenges to neurosurgical ethical care were seen in our study. Multimodal interventions based on the four ethical principles discussed are necessary to improve ethical neurosurgical decision-making in this low resource setting.
Analysis of Clinical Characteristics, Treatment, and Prognostic Factors of 106 Breast Cancer Patients With Solitary Pulmonary Nodules
Authors: He Lihong , Wang Xiaorui , Liu Xiaodong , Jia Yongsheng , Zhao Weipeng , Jia Xiaochen , Zhu Yuehong , Meng Wenjing , Tong Zhongsheng 
Published: February 2022

ObjectiveThe clinical features of solitary pulmonary nodules (SPN) in breast cancer patients were retrospectively analyzed, and the clinical features of primary lung cancer (PLC) and metastatic pulmonary breast cancer (MBC) in breast cancer patients were compared, and the treatment plan, curative effect and influencing factors were analyzed.MethodsThe clinical data of 106 patients of SPN combined with breast cancer surgery in our hospital from January 2015 to June 2020 were analyzed. There were 65 patients of PLC and 41 patients of MBC. Record the characteristics of the primary breast cancer lesion in our patient, the interval between the initial diagnosis of breast cancer and the appearance of SPN, the previous treatment history of our patient, and the characteristics and surgical method of SPN. The survival status of all patients during the follow-up period was recorded.ResultsThe onset age, interval, maximum nodule diameter, ER expression positive rate and radiotherapy history ratio of PLC patients were higher than those of MBC patients, and the lymph node positive rate and triple negative rate were lower than those of MBC patients (P &lt; 0.05). Median survival was 51 months in patients with PLC and 37 months in patients with MBC. The 1, 3, and 5 year overall survival rates in patients with PLC were higher than those in patients with MBC (P &lt; 0.05). Vascular tumor thrombus, SPN type and chemotherapy were all independent factors affecting the prognosis of patients with breast cancer combined with SPN (P &lt; 0.05).ConclusionPLC patients and MBC patients have significant differences in pathological characteristics, like the onset age, interval, maximum nodule diameter, ER expression positive rate, radiotherapy history ratio, the lymph node positive rate, and triple negative rate. Septum, vascular tumor thrombus, SPN type, and chemotherapy are all independent factors that affect the curative effect of breast cancer patients with SPN. Based on the nature of SPN, it can provide reference for clinicians to decide the treatment plan, improve patients' quality of life and prolong their survival time.
Primary Care Physicians’ Personal and Professional Attributes Associated With Forgoing Own Care and Presenteeism: A Cross Sectional Study
Authors: Cohidon Christine , Mahler Liv , Broers Barbara , Favrod-Coune Thierry , Moussa Amir , Sebo Paul 
Published: February 2022

Objective: The aim of this study was to describe the prevalence of forgoing care and forgoing sick leave among primary care physicians (PCPs) in Switzerland and to investigate associated factors.Methods: A random sample of 1,000 PCPs in French-speaking regions of Switzerland (participation rate: 50%) was asked whether they had forgone care and sick leave during the last year. Sociodemographic, personal and occupational characteristics were recorded. Logistic regressions were performed to study these behaviours.Results: 37% of respondents reported at least one episode of forgoing care and 29% reported an episode of forgoing sick leave. No associations were found between individual characteristics and forgoing care. A heavy workload was the most common reason evoked for forgoing care. Coming to work when sick (presenteeism) was associated with female sex, younger age, having a chronic illness, working in a suburban area and working full-time.Conclusion: A high proportion of PCPs in Switzerland is forgoing own care and continues to work despite sickness. New generations of PCPs should require careful monitoring, and specific solutions should be sought to reduce these harmful behaviours.
Prognostic Value of Glasgow Prognostic Score in Non-small Cell Lung Cancer: A Systematic Review and Meta-Analysis
Authors: Zhang Chuan-Long , Fan Kui , Gao Meng-Qi , Pang Bo 
Published: February 2022

Background: Systemic inflammation is a key factor in tumor growth. The Glasgow Prognostic Score (GPS) has a certain value in predicting the prognosis of lung cancer. However, these results still do not have a unified direction.Methods: A systematic review and meta-analysis were performed to investigate the relationship between GPS and the prognosis of patients with non-small cell lung cancer (NSCLC). We set patients as follows: GPS = 0 vs. GPS = 1 or 2, GPS = 0 vs. GPS = 1, GPS = 0 vs. GPS = 2. We collected the hazard ratio (HR) and the 95% confidence interval (CI).Results: A total of 21 studies were included, involving 7333 patients. We observed a significant correlation with GPS and poor OS in NSCLC patients (HRGPS=0 vs. GPS=1 or 2 = 1.62, 95% CI: 1.27–2.07, p ≤ .001; HRGPS=0 vs GPS=1 = 2.14, 95% CI:1.31–3.49, p ≤ .001; HRGPS=0 vs. GPS=2 = 2.64, 95% CI: 1.45–4.82, p ≤ .001). Moreover, we made a subgroup analysis of surgery and stage. The results showed that when divided into GPS = 0 group and GPS = 1 or 2 group, the effect of high GPS on OS was more obvious in surgery (HR = 1.79, 95% CI: 1.08–2.97, p = .024). When GPS was divided into two groups (GPS = 0 and GPS = 1 or 2), the III-IV stage, higher GPS is associated with poor OS (HR = 1.73, 95% CI: 1.43–2.09, p ≤ .001). In the comparison of GPS = 0 and GPS = 1 group (HR = 1.56, 95% CI: 1.05–2.31, p = .026) and the grouping of GPS = 0 and GPS = 2(HR = 2.23, 95% CI: 1.17–4.26, p = .015), we came to the same conclusion.Conclusion: For patients with NSCLC, higher GPS is associated with poor prognosis, and GPS may be a reliable prognostic indicator. The decrease of GPS after pretreatment may be an effective way to improve the prognosis of NSCLC.
Molecular Docking, Tyrosinase, Collagenase, and Elastase Inhibition Activities of Argan By-Products
Authors: Mechqoq Hicham , Hourfane Sohaib , El Yaagoubi Mohamed , El Hamdaoui Abdallah , da Silva Almeida Jackson Roberto Guedes , Rocha Joao Miguel , El Aouad Noureddine 
Published: February 2022

The argan tree (Argania spinosa (L.) Skeels) is one of the most important floristic resources in Morocco. This Moroccan endemic tree is known for its numerous therapeutic and medicinal uses. In addition to some medicinal and cosmetic uses, argan fruit pulp and press cake are traditionally used by the Berber population for heating and feeding livestock. Molecular docking is an in silico approach that predicts the interaction between a ligand and a protein. This approach is mainly used in chemistry and pharmacology of natural products as a prediction tool with the purpose of selecting plant extracts or fractions for in vitro tests. The aim of this research is to study the evaluation of potential tyrosinase, collagenase, and elastase inhibitory activities of argan fruit press-cake and pulp extracts. Extracts were evaluated for their total phenolic content (TPC), and the major polyphenols of both press-cake and pulp extracts were submitted to molecular docking in order to determine the mechanisms of action of these compounds. Obtained results revealed that fruit pulp had the strongest dermocosmetic activities, as well as the highest TPC, with values above 55 mg gallic-acid equivalent per gram of dry matter (mgeq AG/gDM). Moreover, those results were positively correlated with the docking findings, suggesting that the pulp lead compounds have higher affinity with tyrosinase, collagenase, and elastase action sites. The results here presented are very promising and open new perspectives for the exploitation of argan-tree by-products as cosmetic agents towards the development of new anti-aging products.
Regularity of Fractional Heat Semigroup Associated with Schrödinger Operators
Authors: Li Pengtao , Qian Tao , Wang Zhiyong , Zhang Chao 
Published: February 2022

Let L=−Δ+V be a Schrödinger operator, where the potential V belongs to the reverse Hölder class. By the subordinative formula, we introduce the fractional heat semigroup {e−tLα}t>0, 0<α<1, associated with L. By the aid of the fundamental solution of the heat equation: ∂tu+Lu=∂tu−Δu+Vu=0, we estimate the gradient and the time-fractional derivatives of the fractional heat kernel Kα,tL(·,·), respectively. This method is independent of the Fourier transform, and can be applied to the second-order differential operators whose heat kernels satisfy the Gaussian upper bounds. As an application, we establish a Carleson measure characterization of the Campanato-type space BMOLγ(Rn) via the fractional heat semigroup {e−tLα}t>0.
PENYULUHAN DAN PEMERIKSAAN KADAR HAEMOGLOBIN SERTA PEMERIKSAAN TELUR CACING SOIL TRANSMITTED HELMINTHS (STH) PADA ANAK SD N 105302 DI DESA TANGKAHAN KEC. NAMORAMBE KAB. DELI SERDANG
Authors: Mutia Liza , Br Surbakti Karolina , Riadi Selamat 
Published: February 2022

ABSTRAK
Infeksi STH (Soil transmitted helmiths) biasanya tidak menyebabkan kematian, tetapi menyebabkan infeksi kronis dan morbiditas yang berkepanjangan terutama pada anak SD karena pada usia SD anak beresiko tinggi terinfeksi kecacingan, hal ini disebakan pada usia SD belum mengerti untuk menjaga kebersihan dirinya dan juga pada usia ini anak lebih banyak beraktifitas dengan tanah. Metode pelaksanan pengabdian maasyarakaat ini adalah dengan metode pembelajaran bercerita yang dapat mengundang rasa ingin tahu dan ketertarikan anak terhadap sesuatu yang menjadi materi pembelajaran. Metode ini diharapakan menarik minat anak dengan menunjukkan ekspresi anak SD Negeri 105302 Desa Tangakahan Kecamatan Namorambe Kabupaten Deli serdang.
Peserta berjumlah 76 siswa SD dengan rincian siswa kls IV berjumlah 24 orang (31 %), Kelas V berjumlah 21 orang (28 %) dan kelas VI berjumlah 31 orang (41%), Setelah dilakukan pemeriksaan telur cacing STH pada faeces/ tinja ditemukan 3 siswa (4 %) Siswa terinfeksi kecacingan dan sebanyak 73 siswa 96%) siswa tidak terinfeksi kecacingan. Pada pemeriksaan kadar Haemoglobin seluruh siswa memiliki kadar Haemoglobin (Hb)normal. Dari hasil pengabdian masyarakat dapat disimpulkan bahwa siswa SD tersebut sudah dapat meningkatkan pengetahuan tentang manfaat kebersihan diri dan bahaya kecacingan
Magnetically Driven Soft Continuum Microrobot for Intravascular Operations in Microscale
Authors: Liu Dan , Liu Xiaoming , Chen Zhuo , Zuo Zhaofeng , Tang Xiaoqing , Huang Qiang , Arai Tatsuo 
Published: February 2022

Remotely controlled soft continuum robots with active steering capability have broad prospects in medical applications. However, conventional continuum robots have the miniaturization challenge. This paper presents a microscale soft continuum microrobot with steering and locomotion capabilities based on magnetic field actuation. The magnetically driven soft continuum microrobot is made of NdFeB particles and polydimethylsiloxane (PDMS), and it can be as small as 200
μ
m in diameter. Moreover, a hydrogel layer is covered on the surface of the microrobot, which not only overcomes the adhesion force between the microobjects and the soft tip but also reduces the friction between the microrobot and substrate. The performance test indicates the soft continuum microrobot featured excellent control and steering capabilities. The experimental results demonstrate that the soft continuum microrobot can travel through the microfluidic channel by its own vibration and flexibly steer in a bifurcation environment. Moreover, the micromanipulation of microbeads in the microfluidic channels proves that the proposed microscale soft continuum microrobot has a great potential for intravascular manipulation.
Atención triaje y gestión de calidad del servicio de emergencia. Caso: Hospital Luis Fernando Martínez de Cañar
Authors: Molina-Narváez José Ricardo , Castillo-Galvis Sergio Hernando 
Published: February 2022

Objetivo: Analizar la atención Triaje y gestión de calidad del servicio de emergencia en el Hospital Luis Fernando Martínez de Cañar del Ecuador. Método: Descriptiva observacional no experimental. Resultados: La confianza que el usuario tiene al ser atendido en la unidad de emergencia se encuentra en un 48%, todos estos elementos analizados se enfocan en fenómeno de inseguridad con la que la colectividad acude, afectando la credibilidad, confianza y seguridad del hospital. Conclusión: Se evidencia la necesidad urgente de implementar una propuesta de cambio del sistema asistencial de servicio, con la incorporación de aspectos adecuados de información objetiva y redistribución de los servicios dentro de la unidad de emergencia, todo esto enlazado en la propuesta de la gestión de calificación de Manchester.
Mucormicosis en pacientes inmunodeprimidos por el uso de esteroides en pacientes covid-19
Authors: Alonzo-Pico Olga Mireya , Guerrero-Morán Paola Estefanía , Córdova-Vizcaino Josselyn Belén , Guepud-Guapaz Anderson Ramiro 
Published: February 2022

Objetivo: analizar la relación de pacientes críticos por Covid-19 y la relación con la murcomicosis. Método: Descriptiva documental con diseño bibliográfico. Resultados: La mucormicosis puede afectar la nariz, los senos nasales, la órbita, el sistema nervioso central (SNC), los pulmones (pulmonar), el tracto gastrointestinal (GIT), la piel, los huesos de la mandíbula, las articulaciones, el corazón, los riñones y el mediastino (tipo invasivo), pero la ROCM es la más común variedad observada en la práctica clínica en todo el mundo. Conclusión: Los médicos deben estar atentos a la posible aparición de mucormicosis en los pacientes que se recuperan de la enfermedad por COVID-19, especialmente que han sido tratados con esteroides u otros medicamentos para reducir la inflamación pulmonar y posibles manifestaciones clínicas de dolor facial u orbitario o secreción nasal negra o teñida de sangre.
Factores asociados a la anemia infantil. Caso: Ex Micro Red de Salud San Bartolo. Perú
Authors: Céspedes-Ayala Asunta 
Published: February 2022

Objetivo: Identificar los factores asociados a la anemia infantil en la Ex Micro Red de Salud San Bartolo, 2018. Metodología: Se realizó un estudio observacional, prospectivo y retrospectivo. Transversal diseño no experimental con enfoque de investigación cuantitativa, siendo un estudio analítico. La población de estudio estuvo constituida por niños de 6 a 35 meses de edad con anemia y sin anemia. Se aplicó un Instrumento validado por el centro de investigación de Salud Pública. Resultados: La prevalencia de anemia en menores de 6 a 35 meses fue 39.2% y la anemia leve representa un 89.7% del total de anemia. La media de concentración sérica de Hemoglobina en niños anémicos en la Ex Micro Red de Salud de San Bartolo fue 10.19 mg/dl (p=0.0001). Conclusión: La anemia a temprana edad está asociada a la poca reserva de hierro que le provee la madre directamente y el déficit control prenatal gestante.
IMPLEMENTASI MEDIA VIDEO PEMBELAJARAN DALAM PEMBELAJARAN JARAK JAUH PADA MATA PELAJARAN MATEMATIKA KELAS IV DI SD NEGERI 1 CIBANGKONG
Authors: Aristiya Maulani Eka , Muslim Arifin 
Published: February 2022

Penelitian ini dilakukan di SD Negeri 1 Cibangkong Kabupaten Banyumas. Penelitian ini bertujuan untuk mengetahui cara guru mengimplementasikan media video pembelajaran dalam pembelajaran jarak jauh pada mata pelajaran matematika kelas IV di SD Negeri 1 Cibangkong. Berdasarkan observasi yang dilakukan di kelas IV dalam proses mengimplementasikan media video sebagian besar siswa antusias saat pembelajaran jarak jauh dilakukan oleh guru dengan mengimplementasikan media video pembelajaran matematika . Penelitian yang akan dilaksanakan oleh peneliti adalah penelitian kualitatif. Keabsahan data menggunakan triangulasi. Teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Pengujian triangulasi dilakukan peneliti menggunakan triangulasi sumber dan triangulasi teknik. Hasil penelitian menunjukan bahwa mengimplementasikan media video pembelajaran dalam pembelajaran jarak jauh pada mata pelajaran matematika kelas IV di SD Negeri 1 Cibangkong dapat membantu untuk proses pembelajaran siswa. Pelaksanaan implementasi media video pembelajaran matematika sudah berjalan dengan baik sehingga sebagian besar siswa dapat mengikuti pembelajaran jarak jauh. Mengimplementasikan media video untuk pembelajaran matematika di kelas IV dilakukan oleh guru kelas sendiri dengan cara video dibagikan oleh guru, guru memberi petunjuk untuk menggunakan video, setelah itu guru meminta siswa untuk menyimak video dan mencatat hal-hal penting yang berkaitan dengan isi materi dari video, kemudian yang terakhir adanya pemberian tugas. Adanya implementasi media video sebagai fasilitas untuk proses pembelajaran. Meskipun pada saat mengimplementasikan media video pembelajaran dalam pembelajaran jarak jauh pada mata pelajaran matematika di kelas IV SD Negeri 1 Cibangkong tidak lepas dari beberapa faktor pendukung dan penghambat. Kata Kunci: Implementasi, Media video, Pembelajaran Jarak Jauh (PJJ).