bluuebunny/crossref_metadata_2025_split huggingface dataset:
Water resistant soil stabilization via a mussel mimicry ultra-low swelling hydrogel
Authors: Zhao Zhi , Shan Yupeng , Wang Haibin , Lu Hao , Liu Xuemei , Wang Bowen , Song Xiaoyan 
Published: April 2022

Abstract
Employing hydrogels as a substitute for cement in soil stabilization is believed to have great environmental benefits. However, current hydrogel soils stabilizers cannot function properly in wet conditions due to swelling induced structural deformation and mechanical weakening, which significantly limits their applications. Inspired by the mussel byssal, we developed a water resistant hydrogel soil stabilizer that worked under all environments. The synergic effect of intermolecular hydrogen bonding and hydrophobic interactions led to the formation of heterogeneous mussel mimicry microstructures that possessed superior toughness and ultra-low swelling ratio. Soils strengthened with such hydrogels maintained great strength in water, which had never been achieved before. The intrinsic water affinity of hydrogels also ensured a decent permeability and retention ability of water, which was critical to ecosystems. The present work holds great promise for developing the next generation environment-insensitive and ecofriendly soil stabilizers.
Glucagon-like peptide-1 receptor PET/CT in patients with and without post gastric bypass hypoglycemia – a prospective, matched case-control study
Authors: Hepprich Matthias , Antwi Kwadwo , Wiesner Patricia , Cavelti-Weder Claudia , Donath Marc Y. , Christ Emanuel R. , Wild Damian 
Published: April 2022

Abstract
Purpose The aim of this pilot study is to prospectively compare in vivo glucagon-like peptide-1 (GLP-1) receptor expression in the duodenum and pancreas of patients with and without postprandial hypoglycemia after gastric bypass using GLP-1 receptor imaging with 68Ga-DOTA-exendin-4 PET/CT.MethodsFive patients after Roux-Y-gastric bypass (RYGB) surgery with postprandial hypoglycemia (PGBH) and five patients after RYGB without PGBH matched for sex, age, operative procedure and postoperative interval underwent 68Ga-DOTA-exendin-4 PET/CT. Total 68Ga-DOTA-exendin-4 uptake in the duodenum and pancreas, defined as the sum of the standard uptake value (SUVsum) for each voxel in the volume of interest (VOI) was measured by two independent readers who were blinded for the clinical information. Additionally, three further patients with PGBH who received 68Ga-DOTA-exendin-4 PET/CT at our center were added to the analysis. Clinical follow-up data was collected for all patients with PGBH.Results68Ga-DOTA-exendin-4 PET/CT exhibited a greater range of total duodenal and pancreatic uptake (SUVsum) for matched hypoglycemic patients (2144-7802, median 3022) than for matched normoglycemic patients (5104-7507, median 7072), with no statistical significant difference of total uptake = total in vivo GLP-1 receptor expression (p-value of 0.187). In one patient with PGBH a focal tracer uptake in the pancreatic tail was identified. Four patients with PGBH required ultimately a reversal of their gastric bypass surgery due to insufficient dietary and medical therapy of their hypoglycemic episodes.Conclusion68Ga-DOTA-exendin-4 uptake appears not to be significantly different in patients with PGBH compared to matched normoglycemic patients but may reflect varying stages of the complex pathophysiology of postbariatric hypoglycemia.
Adamts-1 may be a compensatory factor to regulate the brain vascular permeability in hyperemesis gravidarum
Authors: Timur Burcu , Guney Gurhan 
Published: April 2022

Abstract
Background: We aimed to investigate the levels of ADAMTS-1, which is secreted from the extracellular matrix during trophoblastic invasion in hyperemesis gravidarum (HEG).Methods: In this cross-sectional study, we compared 45 HEG patients aged between 21 and 34 in terms of ADAMTS-1 levels with a control group consisting of 44 healthy pregnant women. The demographic characteristics and several laboratory parameters of the patients were recorded. Both groups were also compared in terms of ketonuria. We evaluated the correlation between ADAMTS-1 levels and ketonuria.Results: The 2 groups were matched in terms of age, gestational age, gravidity, parity, and body mass index. Some inflammatory markers, such as neutrophil count, MPV, PDW, and PCT levels, were significantly higher in the HEG groups compared to the control group (all p<0.05). However, mean MCV and serum TSH levels were statistically significantly lower in this group (both p<0.001). ADAMTS-1 levels were 12.6±1.4 ng/ml in the HEG group and 6.2±1.6 ng/ml in the control group (p<0.001). It was significantly and positively correlated with urine ketone, neutrophil count, and PDW, whereas negatively correlated with MCV and TSH value in the HEG group. ROC analysis showed that a threshold value of 11.275 ng/ml for ADAMTS-1 predicted HEG patients with a sensitivity of 60% and specificity of 95.5%.Conclusion: ADAMTS-1 levels are increased in HEG patients, and there is a positive correlation between ADAMTS-1 levels and ketonuria.
Whole-genome and Phylogenetic analysis of Porcine Epidemic Diarrhea Virus Strain CH/JSXZ /2015
Authors: Huan Changchao , Guo Xinyue , Chen Pengxiang , Ni Bo , Zhang Wei , Yao Jingting , Jiang Luyao , Gao Song 
Published: April 2022

Abstract
We report here the complete genome sequence of porcine epidemic diarrhea virus (PEDV) strain CH/JSXZ/2015, from natural onset piglets in Xuzhou, Jiangsu Province, China. The gene sequence of isolate CH/JSXZ/2015 (JSXZ) consists of 42% G + C and 58% A + T. The total length excluding the poly(A) tail is 28,044 nucleotides (nt). At the whole-genome level, CH/JSXZ/2015 showed the highest nucleotide identity (99.5%) with CH/GDZHDM/1401 strain (KR153326.1 and KR153326.1), and the lowest similarity (93.5%) to 85 − 7-mutant1 strain. CH/JSXZ/2015 S amino acid identity was 90.8%‐99.8% compared with other strains. CH/JSXZ/2015 ORF3 amino acid identity was 91.2%‐100.0% compared with other PEDV strains. Phylogenetic analysis based on the whole genome, S and ORF3 revealed that CH/JSXZ /2015 is most genetically close to CH/GDZHDM/1401 strain (KR153326.1 and KR153326.1) isolated in China in 2014. It will assist to understand the trend of popularity and evolution of PEDV in China.
Synergistic effects of Nrf2 inhibitor, brusatol treatment in combination with lapatinib, a selective HER2 tyrosine kinase inhibitor in HER2-positive cancers
Authors: Tian Ziyin , Yang Yan , Wu He , Chen Yongye , Jia Hao , Zhu Lei , He Runjia , Jin Yibo , Zhou Bei , Ge Chunpo , Sun Yanxia , Yang Yun 
Published: April 2022

Abstract
Overexpression of human epidermal growth factor receptor 2 (HER2), a member of the HER family of receptor tyrosine kinases (RTKs), is found in many solid tumors. The dual tyrosine kinase (EGFR/HER2) inhibitor lapatinib is currently used to clinically treat HER2-positive breast cancer. However, a majority of patients do not respond to lapatinib therapy within 6 months when using lapatinib alone. Therefore, potentiating the anti-tumor effect of lapatinib by combination treatment has a great potential to overcome the obstacle. Our findings revealed that brusatol potently enhanced the anti-tumor effect of lapatinib against SK-BR-3, SK-OV-3 and AU565 cancer cells in a synergistic manner. Furthermore, we found that lapatinib plus brusatol more effectively decreased Nrf2 level and induced ROS generation in both SK-BR-3 and SK-OV-3 cells. Moreover, we also observed a significant reduction on the phosphorylation of HER2, EGFR, AKT and ERK1/2 in SK-BR-3 and SK-OV-3 cells when treated with lapatinib plus brusatol compared to either agent alone. More importantly, brusatol significantly augmented the anti-tumor effects of lapatinib in the SK-OV-3 xenograft model. In summary, these data provide a potential rationale for the combination of brusatol and lapatinib on the treatment of HER2-positive cancers.
Effect of Behavioral Therapy Counseling on Infantile Colic in Infants of Anxious Mothers: A Randomized Controlled Clinical Trial
Authors: Montazeri Reihaneh , Hasanpour Shirin , Mirghafourvand Mojgan , Gharehbaghi Manizheh Mostafa , Tehrani Mohammad Mehdi Ghods , Rezaei Shiva Mohajjel 
Published: April 2022

Abstract
Background: Given the possible effect of maternal anxiety on the severity of colic pain in infants, this study aimed to investigate the effects of behavioral therapy counseling on infantile colic (primary outcome), maternal anxiety, and mother-infant attachment (secondary outcomes) in anxious mothers with colicky infants.Method: In this randomized controlled clinical trial, the researcher enrolled 46 anxious mothers of 2­­­­­–6-weeks-old exclusively breastfed colicky infants with Postpartum Specific Anxiety Scale (PSAS) scores ≥ 112 admitted to the pediatric clinics of Al-Zahra, Taleghani and Children Hospitals of Tabriz, Iran. The participants were randomly assigned to the intervention (n = 23) and control (n = 23) groups using randomized block design. Mothers in the intervention group attended 8 systematic desensitization counseling sessions (2-3 sessions per week). Those in the control group received routine care. The researcher completed the Postpartum Specific Anxiety Scale (PSAS), Mother-Infant Attachment Questionnaire (MIAQ), and Infant Colic Scale (ICS) by interviewing the participants before and two weeks after the intervention.Results: There was no significant difference between the two groups in terms of socio-demographic characteristics (P < 0.05). After the intervention, the mean postpartum anxiety score of women in the intervention group was significantly lower than that of those in the control group (MD = 22.5, 95% CI = 2.3 to 42.7; p = 0.029). The mean infant colic score of the infants of mothers in the intervention group was insignificantly lower than that of those in the control group (MD = -2.9, 95% CI = -8.3 to 2.4; p = 0.271). In addition, no significant difference was observed between the two groups in terms of their mean mother-infant attachment scores (MD = -0.04, 95% CI = -3.1 to 0.3; p = 0.976).Conclusion: Behavioral therapy counseling effectively reduced postpartum anxiety in women with colicky infants; however, this reduction did not lead to a significant decrease in the infants’ colic pain. Therefore, health care providers are recommended to use this counseling method in combination with other effective counseling approaches to promote mental health of these mothers.Trial Registration: IRCT Registration Number: IRCT20111219008459N14, registered on October 08, 2020. https://irct.ir/user/trial/45949/view
Abnormal patellar pressure may lead to femoral trochlear dysplasia: an experimental study of patellar hypermobility and patellar dislocation in growing rats
Authors: Tang Shiyu , Li Weifeng , Wang Shengjie , Xu Chenyue , Zhao Chao , Wang Fei 
Published: April 2022

Abstract
Background: This animal study aimed to explore the effects of patellar hypermobility and patellar dislocation on the developing femoral trochlea.Methods: Seventy-two 3-week-old Wistar rats were randomly divided into three groups. The sham group (SG) underwent simple incision and suture of the skin and subcutaneous tissue; the patellar hypermobility group (PHG) underwent medial and lateral retinacular release; the patellar dislocation group (PDG) underwent plication of the medial patellofemoral retinaculum. Twelve rats in each group were euthanized at 3 and 6 weeks postoperatively, respectively, and specimens were collected. The bony sulcus angle (BSA), cartilaginous sulcus angle (CSA), trochlear sulcus depth (TSD), and thickness of the cartilage on the lateral facet (CTL), medial facet (CTM), and center (CTC) of the trochlea were measured on hematoxylin and eosin-stained sections.Results: In the PHG and PDG, the femoral condyles became blunt, the trochlear groove became shallower, and cartilage became thicker compared with the SG. Compared with the SG, the PHG and PDG had significantly larger BSA and CSA values at 3 (p < 0.05) and 6 weeks (p < 0.005), and a significantly shallower TSD (p < 0.05). At 3 weeks, all cartilage thicknesses in the PHG and the CTC and CTM in the PDG were significantly thinner than in the SG (PHG vs SG: p = 0.009 for CTL, p < 0.001 for CTM, p = 0.003 for CTC; PDG vs SG: p = 0.028 for CTC, p = 0.048 for CTM). At 6 weeks, the CTC was thicker in the PHG and PDG than the SG (PHG vs SG: p = 0.044; PDG vs SG: p = 0.027), and the CTL was thinner in the PDG than the SG (p = 0.044).Conclusion: Patellar hypermobility and patellar dislocation may result in trochlear dysplasia that worsens with age. Excessive or insufficient stress leads to trochlear dysplasia.
A novel synthesis method of cyclopentadecanone and cyclopentadecanolide from vegetable oil
Authors: Liu Pin , Li Weiguang , Liu Xiongmin 
Published: April 2022

Abstract
Malania oleifera Chum is a unique renewable plant resource in China, its fruit oil has a high content of 15-tetracosenic acid, and it is a good raw material for the synthesis of cyclopentadecanone and cyclopentadecanolide. A Novel synthesis method of cyclopentadecanone and cyclopentadecanolide from vegetable oil was designed, and the synthesis yields of c cyclopentadecanone and cyclopentadecanolide were 38.5% and 63.0%, respectively. The effect of different ester groups on cyclization of α, ω-difatty acid alkyl ester in cyclopentadecanone synthesis, and effect of catalysts on cyclization of ω-hydroxycarboxylic acid triglyceride in cyclopentadecanolide synthesis were investigated. The designed synthesis strategy has the characteristics of less synthesis steps and high utilization efficiency of 15-tetracosenic acid, which has simple and economic.
Social Capital and Community Resilience in Tōhoku-Oki: Lessons from the 2011 Great East Earthquake and Tsunami Disaster in Japan
Authors: Siawsh Nidam Marcus , Peszynski Konrad , Vo-tran Huan , Young Leslie 
Published: April 2022

Abstract
In crisis and disaster management research, social capital is often examined to understand the impacts of disasters and crises on society. This paper investigates experiences of how local cultural norms and social capital influenced the disaster relief process following the 2011 Great East Japan Earthquake and Tsunami (GEJET) disaster. To underline social capital’s multiple‐influence aspects, this paper draws from field research that focuses on collective and individual social capital in disaster relief to systematise the findings according to the social capital framework. The paper analyses the 2011 GEJET to uncover new effects of individual social capital and collective capital in a mega-disaster context, thus contributing to pushing the research agenda toward a more critical appraisal of individual social capital and collective capital. This research contributes to the nascent but growing literature that clarifies the relationship between social capital and disaster resilience. A qualitative study using in-depth interviews with eight humanitarian professionals was conducted to capture the essence of their shared experiences. Using a thematic analysis, findings from the study revealed three main themes capturing the essence of the research participants’ disaster experiences. First, disaster response relied mostly on locally driven relief due to a clear understanding of the local culture. Second, there was an urgency to establish a sense of normalcy by providing quality supplies that would help survivors. Third, Japanese gender roles and expectations were reflected in the disaster relief process. The three themes establish a wide array of lived experiences that are important to reflect on the role social capital plays in the policy-making and needs assessment processes in post-disaster relief and response efforts. The findings provide insights for integrating social dimensions into a humanitarian aid culture as citizens work towards a sense of normalcy. The findings present new knowledge on humanitarian workers’ experiences concerning social capital influence and disaster relief. Comparing the emerging themes of the research to the framework of social capital, the study provides a broader and deeper understanding of the application of culture and social capital to disaster relief in the aftermath of a major disaster
Forest fire influence on Tomicus piniperda-associated fungal communities and phloem nutrient availability of colonized Pinus sylvestris
Authors: Kluting Kerri , Strid Ylva , Six Diana , Rosling Anna 
Published: April 2022

Abstract
Forest fire is known to positively affect bark beetle populations by providing fire-damaged trees with impaired defenses for infestation. Tomicus piniperda, the common pine shoot beetle, breeds and lays eggs under the bark of stressed pine trees and is considered a serious forest pest within its native range. Wood-colonizing fungi have been hypothesized to improve substrate quality and detoxify tree defensive chemistry to indirectly facilitate tree colonization by beetles. While some bark beetle species form symbiotic associations with fungi and actively vector their partners when colonizing new trees, T. piniperda does not have mycangia or body hairs for specific vectoring of fungi. To explore the T. piniperda-associated fungal community for signs of specific association, we used ITS metabarcoding to separately characterize fungal communities associated with surface and gut of male and female beetles. We also characterized the temporal changes in fungal community and nutrient status of pine phloem with and without beetle galleries. Sampling was performed two years after a natural forest fire and included both burnt and unburnt sites. In our study system, we find that forest fire significantly impacts the fungal community composition associated with T. piniperda and that fire may also indirectly change nutrient availability in phloem to beetle galleries. We conclude that T. piniperda can vector fungi to newly colonized trees but the absence of positive effects on substrate quality and minimal effects of sex indicate that vectoring of associated fungal communities is not a strategy associated with the T. piniperda life cycle.
B7-H3 targeted CAR-T cells show highly efficient anti-tumor function against osteosarcoma both in vitro and in vitro
Authors: Zhang Qian , Zhang Zhiqiang , Liu Guodi , Li Dehua , Gu Zhangjie , Zhang Linsong , Pan Yingjiao , Cui Xingbing , Wang Lu , Liu Guoping , Tian Xiaoli , Zhang Ziming 
Published: April 2022

Abstract
Background
Osteosarcoma(OS)is one of the foremost common dangerous bone tumors, which mainly happens in children and youths. The combination of surgery, radiotherapy and chemotherapy are the common therapies for osteosarcoma treatment. Unfortunately, many patients still experience recurrence or lung metastasis after the current treatments against osteosarcoma. Thus, developing new therapies is urgently needed for improving the current osteosarcoma treatment effect. CAR-T, a cellular immunotherapy with genetically engineered T cells bearing chimeric antigen receptor targeting specific tumor-associated antigen, has been proved to be an effective therapy against acute lymphoblastic leukemia Thus, CAR-T is a potentially effective therapy for osteosarcoma treatment.
Methods
A CAR gene targeting B7-H3 antigen was constructed into lentiviral vector through molecular biology techniques. Then, the CAR gene is transferred to T cells through lentiviral delivery system and the CAR-T cells were largely expanded using in vitro culture technology. The in vitro anti-tumor effect of CAR-T cells was evaluated through Real Time Cell Analysis system (RTCA) and ELISA assay. The in vivo anti-tumor capabilities of CAR-T cells were evaluated using the patient-derived xenografts (PDX) model of osteosarcoma.
Results
The third-generation CAR-T cells we constructed could target the B7-H3 antigen, and the T cell phenotype was also consistent with normal T cells; In vitro levels had a clear antitumor effect; The in vivo level embodied the superior antitumor effect in the osteosarcoma PDX model.
Conclusion
Our study showed that B7-H3 targeted CAR-T cells had high anti-tumor efficacy against osteosarcoma both in vitro and in vivo, which proved that B7-H3 targeted CAR-T is an potentially effective treatment for osteosarcoma.
Efficient integrated photo-charging storage device operating at 3 V
Authors: Han Juyeon , Lee Junyeong , Kim Myeongjin , Cha Hyojung , Jo Sungjin , Yoo Jeeyoung 
Published: April 2022

Abstract
We propose a high-voltage driven photo-charging storage device by integrating series-connected perovskite solar cell and an supercapacitor. The photo-charging storage device exhibits superior overall efficiency of 13.17% at 1 mA cm− 2 and 9.87% at 20 mA cm− 2, attributed to high storage efficiency over ~ 70% at all discharge current densities. This high discharge current density is the record value in all the integrated solar cell and electric double layer capacitor system. Moreover, the photo-charging storage device is maintained at 78.6% of its overall efficiency after 100 cycles under AM 1.5 G illumination and exhibits remarkable cycle performance under indoor light illumination. By impedance analysis, interfacial behavior of photo-charging storage device is demonstrated at the first time. In addition, to avoid the decomposition of perovskite solar cell active layer with moisture, the encapsulation process is conducted. These results underline the high potential of this photo-charging storage device as a distributed power source.
Pulsed Electric Field Effect Pretreatment on the Behavior of Microwave-assisted Pomegranate Arils (Punica granatum L.) Hot air Drying
Authors: Amiali Malek , BRIKI Samia , BECHAA Besma , Zitouni Bariza , Raghavan G.S. Vijaya 
Published: April 2022

Abstract
Pulsed electric field treatment is a new, non-thermal pretreatment method that preserves foods forexcellent sensory, nutritional and long-life quality. In this study, the impact of pulsed electric field pretreatment on drying kinetics and the quality of dried pomegranate arils was evaluated. The pomegranate arils samples were subjected to pulsed electric field treatment at different intensities of the electric field of 0.5, 1 and 1.5 kV/cm with application of exponentialpulses of 700 µsduration followed by Microwave-assisted Hot air drying. the samplesweredried at 50, 60 and 70°C with a drying times varying from 65 to 190 minutes, while, for untreated arils, the drying time was varying from 90 to 250 minutes. The highest water diffusion coefficient of 8.25 × 10− 8 m2/s was calculated for samples subjected to electric field intensity of 1.5 kV/cm and 70°C treatment temperature. The greatest Hardness was 39.35 ± 4.81 N. The pulsed electric field arils treatments resulted in better electroporation ofthe tissues. The Pulsed electric field -treated dried arils had higher red (a*) and yellow (b*) and (L*) values compare to untreated dried arils.These dried arils are characterized by a high content of total polyphenols 3350.28 mg GAE/kg DM and high antioxidant capacity (0.6 mg eqTrolox g− 1).The drying kinetics were modeled by different models. The models that best fit the drying data was Midilli et al., followed by Logarithmic and modified logistic model.