bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glucocorticoid Use and Misuse in a Rural Community of Kerala, India
Authors: Mulavelil Rachel , Finny Philip , David Alice , Samuel Preethy S. , Armstrong Lois J. 
Published: August 2022

Abstract

Background:
Glucocorticoids (GCs) are anti-inflammatory steroid medications prescribed globally by doctors for various illnesses and they are known to produce quick symptom relief. In India, they are among the cheapest and easily accessible over-the-counter medications. Thus, it can be misused, leading to many life-threatening illnesses such as diabetes mellitus, hypertension, overwhelming infections, Cushing’s syndrome, and hypo-adrenal crisis.

Objective:
This study reports the misuse of GCs in a rural community in the state of Kerala, India, and compares it with the only other community GC misuse study in India, from the state of Bihar.

Methods:
A community-based cross-sectional survey of 452 households comprising 1,734 people was conducted in rural Konni, Kerala, during June and July of 2019. In each house, people who had been taking medications over the previous 6 months were interviewed.

Results:
Almost 2% (n = 31) had consumed one or more GCs in the last 6 months (95% CI: 1.3–2.5%). Of these, 26% (n = 8) were taking oral GCs and 36% (n = 11) of them were inappropriately using them based on current clinical guidelines. 29% (n = 9) had used GCs for more than 1 month.

Conclusions:
GC misuse exists in Kerala but not to the extent seen in Bihar. In Kerala, inhaled GCs are more common than oral GCs, and the prescription is obtained predominantly from qualified medical practitioners. The prevalence of prolonged GC use could be implicated as an underlying factor for diabetes, hypertension, osteoporosis, and cataracts. It is possible that approximately 220,000 people in Kerala may have a suppressed hypothalamus-pituitary-adrenal axis which can predispose them to a fatal hypo-adrenal crisis.
The Comparison of the Effects of three Meals Feeding a Day and Four Meals Feeding a Day in Type 2 Diabetes Mellitus Hospitalised Patients in Thammasat University Hospital on Blood Sugar Control and Enteral Feeding Complications
Authors: Wongwatanasanti Kwansuphang , Wichansawakun Sanit 
Published: August 2022

Abstract

Background:
As malnutrition negatively impacts hospital outcomes, hospitalised patients should receive proper nutritional management. Enteral nutrition (EN) is the most common route for non-volitional dietary support, usually fed four times/day. It is different from patients with volitional feeding who receive only three meals/day. This practice may affect blood glucose (BG) control in enteral feeding diabetes patients and increase nursing care’s working burden. As a result, the study aimed to compare BG control and enteral feeding complications between 3 and 4 times feeding/day in hospitalised diabetes patients who require EN.

Methods:
A non-blind randomised controlled trial study was conducted in 37 types two diabetes hospitalised patients who required EN in Thammasat University hospital (TUH) from April 1 to December 31, 2019. The study patients were randomised and stratified by HbA1C at <8% or ≥8% to treat three meals or four meals/day. BG was controlled based on the insulin injection protocol of TUH. The study data was collected at least five days until the patients were stopped EN or discharged from the hospital. The primary outcome was a percentage of times BG was in controlled at ≤180mg/dl. The secondary outcomes were any feeding complications such as frequency of hypoglycemia, diarrhea and gastric residual volume over 100 ml before the next feeding time.

Results:
37 patients were included. 83% of the patients were female, and the mean age was 78.44 ± 8.14 and 74.11 ± 10.03 years old in three meals and four meals feeding group, respectively. There were none significant in mean percentage of BG control between three times and four times/day either in HbA1C <8% and HbA1C ≥8% (52.21% and 68.43%, P value = 0.192 and 54.29% and 55.10%, P value = 0.942, respectively). Percentage of hypoglycemic events were none significant in 3 vs 4 times feeding at 1.70% vs 0.99%, P value = 0.552 and 2.53% vs 2.00%, P value = 0.727 in HbA1C <8% and HbA1C ≥8%, respectively. However, other complications were not significant between two groups.

Conclusion:
There was no clinically significant outcome on BG control and other complications between three and four times feeding/day in type 2 diabetes hospitalised patients. Therefore, three times feeding can be implied in clinical practice to reduce the burden of nursing care.
Induction of Endometrial HOXA 10 Gene Expression by Vitamin D and its Possible Influence on Reproductive Outcome of PCOS Patients Undergoing Ovulation Induction Procedure
Authors: Shilpasree AS , Kulkarni Vinuta B. , Shetty Praveenkumar , Bargale Anil , Goni Mallikarjun , Oli Ajaykumar , Sarathkumar E , Patil Vidya S. , Desai Rathnamala M. 
Published: August 2022

Abstract

Background and Objectives:
Polycystic ovarian syndrome (PCOS) is one of the most common endocrinopathies in women frequently presenting with anovulatory infertility. Low successful pregnancy and live birth rates even after successful ovulation induction (OI) and in vitro fertilization (IVF) in these patients indicate that endometrial dysfunction may be another important factor contributing to infertility. Vitamin D acting through nuclear receptors induces the expression of various genes required for cell growth and differentiation and plays a crucial role in reproduction. Homeobox 10 (HOXA10) may be one of the potential targets for vitamin D action. HOXA10 gene product promotes the differentiation of endometrial cells, making the endometrium receptive for implantation. The present study was undertaken to determine the effect of circulating vitamin D levels on HOXA10 gene expression in endometrial tissues and its possible influence on the reproductive outcome of PCOS patients undergoing OI procedure.

Materials and Methods:
A prospective cohort study was conducted on 110 infertile PCOS patients. The patients were divided into two groups: Group 1: Vitamin D ³20 ng/ml, Group 2: Vitamin D <20 ng/ml. Endometrial samples were obtained from 22 patients using pipelle biopsy, used to determine HOXA10 mRNA (messenger ribonucleic acid) expression by quantitative RT-PCR (reverse transcription-polymerase chain reaction) and protein expression by Western blotting. OI was performed using Clomiphene citrate or Letrozole from the 3rd day of the cycle, and patients were followed up for a maximum of five cycles. Attainment of successful pregnancy was considered a positive outcome.

Results:
Both the groups were similar in mean age and other endocrine parameters. Serum vitamin D levels were significantly low (P < 0.001), and BMI (body mass index) was significantly high (P = 0.032) in group 2 compared to group 1. Endometrial HOXA10 mRNA (by quantitative rtPCR) and protein expression (by western blotting) were significantly low in group 2 compared to group 1. The clinical pregnancy rate was low in group 2 (28.6%) compared to group 1 (42.3%), but this difference was not significant (P = 0.22). On regression analysis adjusted for age and BMI, vitamin D was an independent predictor of successful pregnancy after OI (P = 0.09).

Conclusion:
Circulating vitamin D levels influence the endometrial HOXA10 gene expression, and this may be reflected on the reproductive outcome of infertile PCOS patients undergoing OI.
Implications of Cell Adhesion Molecules in Autism Spectrum Disorder Pathogenesis
Authors: Sindi Ikhlas A. 
Published: August 2022

Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental illness that leads to repetitive behavior and debilitates social communication. Genetic changes such as susceptible genes and environmental factors promote ASD pathogenesis. Mutations in neuroligins (NLGNs) and neurexin (NRXNs) complex which encode cell adhesion molecules have a significant part in synapses formation, transcription, and excitatory–inhibitory balance. The ASD pathogenesis could partly, at the least, be related to synaptic dysfunction. Here, the NRXNs and NLGNs genes and signaling pathways involved in the synaptic malfunction that causes ASD have been reviewed. Besides, a new insight of NLGNs and NRXNs genes in ASD will be conferred.
Oral Mucous Membrane Pemphigoid
Authors: Babu Cathy , Tamgadge Sandhya , Vidhale Rutuja Gajanan , Pereira Treville 
Published: August 2022

Abstract
Pemphigoid is a group of rare autoimmune diseases affecting the skin and the mucous membrane in which the autoantibodies are directed against the basement membrane zone target antigens causing subepithelial blistering. Oral health professionals are usually the first to identify as more than 90% of cases show oral lesions initially. A lack of diagnostic criteria can lead to misdiagnosis and delay in treatment. We report a unique case of mucous membrane pemphigoid devoid of ocular or cutaneous involvement.
Association between polymorphic <i>eNOS</i> gene markers and risk of primary open-angle glaucoma in the Perm Region population
Authors: Gavrilova Tatyana V. , Kinkulkina Aliya R. , Avagyan Hasmik S. , Svitich Oksana A. 
Published: August 2022

Glaucoma is widely known to have a progressive course and occupy a leading place among the causes of vision loss and blindness. Increased intraocular pressure is the key harmful factor among the causes of glaucoma occurrence. In some cases, however, the progressive disease is also observed at normal values of ophthalmic tonus. Early diagnosis of glaucoma will allow for timely therapy, which in turn will reduce the risk of complications and prevent neuroopticopathy progression. According to the literature data, the pathogenesis of primary open-angle glaucoma is associated with nitric oxide (NO), due to imbalance between endothelium-produced vasoconstrictors and vasodilators, especially, endotelin-1 and nitric oxide. Decreased NO level combined with endotelin-1 hyperproduction is associated with development and progression of a number of ocular disorders including glaucomatous atrophy of the optic nerve. Since nitric oxide is produced by endothelial NO-synthase (eNOS), one may assume that eNOS is involved in pathogenesis of neurodegenerative changes in primary open-angle glaucoma. However, despite numerous studies on the pathogenesis of glaucoma, the distinct factors of innate immune response remain poorly studied. The purpose of the present study was a search for association between polymorphic markers (C774T, T786C, Glu298Asp) of the eNOS gene and the risk of primary open-angle glaucoma among the Perm Region residents.
Peripheral blood of patients with primary open-angle glaucoma (the main group) and cataract without glaucoma (a comparison group) was used as initial biomaterial. In comparison group, arterial hypertension was most often encountered as concomitant pathology. Genomic DNA was first isolated from the blood samples, followed by rt-PCR using reagent kits for determining C774T, T786C, Glu298Asp polymorphic markers in the eNOS gene.
The prevalence of polymorphic variants of the innate immunity genes T786C, C774T and Glu298Asp of the eNOS gene was analyzed in patients with primary open-angle glaucoma. There were no significant differences in the distribution of genotypes and alleles of eNOS gene for the C774T and Glu298Asp polymorphic markers. An increased frequency of homozygous TT genotype was found, along with decreased occurrence of C allele at the polymorphic T786C locus of the eNOS gene, as well as a trend for decreased frequency of the TC and CC genotypes. Arterial hypertension potentiated the negative effect of increased intraocular pressure upon the glaucoma-associated optic neuropathy. Conclusions. The studied changes in genotypes and allelic frequencies of eNOS gene may be regarded as risk factors that increase probability of the primary open-angle glaucoma and predict severity of the disease.
Pengaruh Kompetensi Sumber Daya Manusia, Penerapan Standar Akuntansi Pemerintahan dan Sistem Pengendalian Intern Terhadap Kualitas Laporan Keuangan
Authors: Adhillah Mona Nur 
Published: August 2022

Penelitian ini bertujuan untuk mengetahui pengaruh Kompetensi Sumber Daya Manusia, Penerapan Standar Akuntansi Pemerintahan dan Sistem Pengendalian Intern terhadap Kualitas Laporan Keuangan Provinsi Sumatera Selatan. Populasi dalam penelitian ini adalah Organisasi Perangkat Daerah (OPD) di Provinsi Sumatera Selatan. Jenis penelitian ini adalah penelitian kuantitatif dengan teknik pengambilan sampel menggunakan purposive sampling. Metode pengumpulan data melalui kuesioner yang disebarkan kepada 105 responden yaitu Kasubbag Keuangan, Bendahara Pengeluaran dan pegawai/staf yang melaksanakan fungsi akuntansi di Organisasi Perangkat Daerah (OPD) Provinsi Sumatera Selatan. Penelitian ini menggunakan alat analisis regresi linier berganda dengan SPSS. Berdasarkan hasil penelitian diketahui bahwa Kompetensi Sumber Daya Manusia, Penerapan Standar Akuntansi Pemerintahan, Sistem Pengendalian Intern secara parsial berpengaruh positif dan signifikan terhadap Kualitas Laporan Keuangan pemerintah daerah Provinsi Sumatera Selatan
Profesionalización de la administración para la sucesión generacional en empresas familiares
Authors: García Román Alberto Quijano , Cortés Roger Manuel Patrón , Chuc Giselle Guillermo , Blum Fernando Medina 
Published: August 2022

El caso abordado presenta uno de los problemas generalizados en las empresas familiares directamente relacionado con los directivos (sean familiares o no), que toman las decisiones para su sobrevivencia y permanencia. Es sabido de acuerdo a la literatura, que, en este tipo de organizaciones, los puestos gerenciales son asignados a los miembros del núcleo familiar con base a lazos filiales y no derivado de un análisis exhaustivo de su capacidad profesional para colaborar con los objetivos de la organización. El estudio incluye aspectos teóricos sobre estrategias de sucesión, profesionalización y posicionamiento en el mercado con un diseño metodológico de caso anidado de tipo ilustrativo pues cuenta con más de una unidad de análisis. Entre los resultados destaca el emprendedurismo del socio fundador y la estrategia que siguió para redefinir el equipo de colaboradores al frente de las áreas que integran la organización, lo cual lleva implícitos costos de operación. Se concluye de acuerdo con la evolución de la empresa que profesionalizar la dirección de la organización es una decisión adecuada y respetada aún por los demás miembros del núcleo familiar; sin embargo, ante la actitud de estos, y a pesar de los resultados financieros, no se garantiza la continuidad de la estructura administrativa implementada cuando el líder fundador deje de ser quien tiene la última palabra en el destino de la empresa.
Sistem Informasi Pengolahan Data Anggota Sanggar Senam Cantik Kerinci Menggunakan Bahasa Pemrograman Java Netbeans
Authors: Hamsiah Hamsiah 
Published: August 2022

Sanggar Senam Cantik merupakan suatu organisasi yang bergerak dalam bidang olahraga. Sistem yang sedang berjalan di Sanggar Senam Cantik saat ini masih terkendala pada proses pengentrian data, pengolahan data, pencarian data dan pembuatan kartu tanda anggota. Pencatatan masih dilakukan secara manual, sehingga laporan yang dihasilkan kurang efektif dan efisien. Sistem Informasi Pengolahan Data Sanggar Senam Cantik Kerinci bertujuan untuk memudahkan admin/petugas dalam pengentiran data, pengolahan data, pencarian dan pembuatan kartu tanda anggota, sehingga tidak membutuhkan waktu yang lama dalam proses pengolahan data.
Dengan dirancangnya sistem informasi ini, diharapkan segala kendala yang ada dapat teratasi dengan baik dan bisa lebih meningkatkan pelayanan terhadap anggota sanggar senam cantik sehingga terwujud sistem yang efektif dan efisien
Implementasi Extreme Programming pada Website Sekolah Tinggi Ilmu Tarbiyah (STIT) Daarul Fatah Tangerang
Authors: Maulana Asep Erlan 
Published: August 2022

Sekolah Tinggi Ilmu Tarbiyah (STIT) Daarul Fatah Tangerang dalam menyebarkan informasi kegiatan kampusnya masih terbatas. Hal ini membuat susahnya masyarakat yang akan mengakses informasi tersebut. Untuk itu penelitian ini bertujuan melakukan perancangan dan implementasi website yang bisa membuat mudahnya akses dan penyebaran informasi kegiatan kampus secara efektif. Metode Extreme Programming digunakan didalam melakukan pengembangan website kampus. Proses pengembangan website dimulai perancangan, desain, pengkodean dan pengujian. Hasil dari perancangan website dapat diimplementasikan secara baik dengan dibuktikan program dan informasi kegiatan pada kampus STIT Daarul Fatah dapat dimasukkan pada website. Dan penyebaran informasi berhasil dengan dibuktikan banyaknya pengunjung yang berkirim pesan pada menu Pesan.
Sosialisasi Penggunaan Media Sosial Tiktok Untuk Meningkatkan Penjualan Di Kampung Akrilik Padang
Authors: Afdhal Muhammad , Prawiro Radius , Fenia Selvi Zola 
Published: August 2022

Abstract
Acrylic Village is a small business that uses TikTok as a promotional medium.Based on the pre-observations that have been carried out by the researchers, Kampung Acrylic suggests that TikTok is very helpful in promoting its products.Based on this, we are interested in conducting community service (PKM) related to Promotional Strategies by utilizing socialization on the use of Tiktok social media to increase sales.
Anticatholicisme au Royaume-Uni et antiprotestantisme en France à la fin du XIXe siècle
Authors: Vaughan Géraldine 
Published: August 2022

L’histoire de l’antiprotestantisme en France sous la IIIe République a été renouvelée notamment par les travaux de Jean Baubérot et de Valentine Zuber qui ont montré comment l’antiprotestantisme confessionnel « traditionnel », animé par des milieux laïques et catholiques, s’était mué en un antiprotestantisme « politique » aux accents parfois racistes. Or, les expressions de haine vis-à-vis des minorités religieuses trouvent leur pendant au Royaume-Uni à la même époque. Dans un contexte britannique protestant majoritaire, ce sont les catholiques, en situation de minorité, qui sont visés par les invectives ultra-protestantes. Le présent article s’attache à étudier dans une perspective comparatiste les manifestations de deux mouvements « anti » diamétralement opposés dans leurs objets de haine – les catholiques outre-Manche, les protestants côté français – mais semblables par leurs méthodes et leurs desseins. Méthodologiquement, il s’appuie notamment sur la typologie dressée par le politiste Anatole Leroy-Beaulieu dans son ouvrage Les doctrines de haine, paru en 1902.
Contaminación Ambiental en hospitales de Latinoamérica en tiempos de Pandemia 2019
Authors: Herrera Robles Corina Gladis , Cumpa López Winston Francesc , Silva Sánchez Oshin , Ramírez Carranza Krisbel María , Tarmeño Bernuy Luis Edgar 
Published: August 2022

La pandemia por COVID-19 o coronavirus, fue notificada inicialmente en China en la ciudad de Wuhan, de fecha 31 mes de diciembre del año 2019. Este virus SARS-CoV-2 tiene como definición un be¬tacoronavirus, comparándose con el MERS-CoV y el SARS-CoV, perteneciendo a la familia de coronavirus cuya característica es tener picos o conocido como espigas teniendo una forma particular de corona ubicada en su superficie, son virus ARN monocatenarios los cuales tienen sentido positivo. La naturaleza de esta revisión sistemática es indicar la problemática de la contaminación ambiental en hospitales de Latinoamérica determinando las causas de dicha problemática; este trabajo tiene un enfoque cualitativo el cual siguió un procedimiento de revisión sistemática PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analysis), cabe mencionar lo siguiente, se utilizaron repositorios de banco de datos de buscadores como GOOGLE ACADEMICO, SPRINGER LINK, REDALYC, PROQUEST, MEDIGRAPHIC y SCIELO, se tuvo en cuenta criterios para su demarcación: años 2019 al 2022 y en dos idiomas: español e inglés.
POLIGAMI TANPA IZIN PENGADILAN DITINJAU DARI HUKUM ISLAM DAN UU NO 1 TAHUN 1974
Authors: ALI SIBRA MALISI  
Published: August 2022

The word polygamy comes from the Greek, polus which means many and gamein or gamos which means marriage. So polygamy is a lot of marriage. Polygamy is a form of marriage where a man at the same time has more than one womanâ€™s wife. As for the reasons Poligami, basically a man can only have a wife. A husband who is married to more than one may be permitted by the parties concerned and the Religious Court has granted permission (Article 3 paragraph (2) of Act Number 1 of 1974). The basis for the granting of polygamy permits by the Religious Courts is set forth in Article 4 paragraph (2) of the Marriage Act (UUP) and also in Chapter IX KHI Article 57. The provisions of polygamy, stipulated in Article 5 of Law Number 1 of 1974 provide conditions against a husband who will be married more than one. Polygamy Procedures. The polygamous procedure under Article 40 of Government Regulation No. 9 of 1974 states that if a husband intends to marry more than one, he is obliged to apply in writing to the court. This is further regulated in Articles 56, 57, and 58 of the Compilations of Islamic Law
KONFIGURASI POLITIK HUKUM PERTANAHAN INDONESIA DALAM PERSPEKTIF TEORI HUKUM RESPONSIF
Authors: Budi Handoyo SH.,MH  
Published: August 2022

The Constitution has mandated the provisions governing agrarian problems, namely in Article 33 paragraph (3) of the 1945 Constitution states â€œEarth and water and the natural resources contained therein are controlled by the State and used for the greatest prosperity of the peopleâ€. Number 5 of 1960 Basic Agrarian Regulations as a juridical basis for national land law. But in subsequent developments many laws and regulations that were never requested by the agrarianlaw were issued. The character of land law products is always in line with the development of political configurations though. Responsive characters emerge during democratic political configurations, while conservative characters emerge during a bureaucratic authoritarian political configuration. To realize democratic political configuration characterized by a responsive legal product, the Government and the legislative body must inevitably pay attention to and implement the implicit values contained in regulations and policies.