bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the expression levels of chemerin, ox‐LDL, MMP‐9, and PAPP‐A in ICVD patients and their relationship with the severity of neurological impairment
Authors: Jia Jianpu , Wang Lixuan , Zhang Liran , Hong Zhen , Xia Ruixue , Zhao Zeyu , Zhang Leguo 
Published: May 2022

AbstractObjectiveThe study aimed to analyze the relationship between expression levels of chemerin, oxidized low density lipoprotein (ox‐LDL), matrix metalloproteinase 9 (MMP‐9) and pregnancy associated plasma protein A (PAPP‐A) in ischemic cerebrovascular disease (ICVD) patients and the relationship between the mentioned indicators and the degree of neurological impairment.MethodsFrom January 2020 to February 2021, a total of 328 cases of ICVD patients were admitted to our hospital, and 240 cases of healthy people (control group) were prospectively recruited into this study. The 328 patients were divided into 2 ischemic subtypes, with 233 cases as acute cerebral infarction (ACI) and 95 cases as transient ischemic attack (TIA). Laboratory tests were compared among the groups. Spearman rank correlation was used to analyze the correlation between chemerin, ox‐LDL, MMP‐9, PAPP‐A levels and neurological deficit. Unconditional logisitic regression was used to analyze the risk factors for neurological deficits.ResultsThe high density lipoprotein cholesterol (HDL‐C), fasting plasma glucose (FPG), chemerin, ox‐LDL, MMP‐9, and PPAP‐A levels in the ACI group were significantly higher than those in the TIA group and control group (p < 0.05, respectively), while the levels of the mentioned indicators in the TIA group were significantly higher than those in control group (p < 0.05, respectively). The levels of the given indicators decreased successively in the severe, moderate, and mild neurological deficits population and control group, with statistical difference. Spearman rank correlation analysis showed that chemerin, ox‐LDL, MMP‐9, and PPAP‐A levels were positively correlated with the degree of neurological deficit in ICVD patients. Unconditional logistic regression analysis showed that chemerin, ox‐LDL, MMP‐9, and PPAP‐A were the independent risk factors for neurological deficit in patients with ICVD.ConclusionLDL‐C, FPG, chemerin, ox‐LDL, MMP‐9, and PPAP‐A were highly expressed in ACI and neurological deficit patients. Chemerin, ox‐LDL, MMP‐9, and PPAP‐A may be the independent risk factors for neurological deficit in patients with ICVD.
The links between active cooperation and eco‐innovation orientation of firms: A multi‐analysis study
Authors: Diez‐Martinez Ines , Peiro‐Signes Angel , Segarra‐Oña Marival 
Published: May 2022

AbstractThe environmental orientation of companies is key for firms to gain a competitive advantage against peers. However, the high level of novelty and uncertainty involved with eco‐innovations requires additional knowledge and capabilities that go beyond the firm and that can be achieved through cooperation. Thus, it is crucial to analyse how cooperation affects the elements that drive eco‐innovation. This study tests the impact of cooperation on the environmental orientation of companies while innovating using structural equation modelling with partial least squares and multigroup analysis and a fuzzy‐set qualitative comparative analysis for a sample of Spanish companies. Results suggest that companies that do not cooperate are less eco‐innovation‐oriented and show lower dependence on external information sources, although their impact on the orientation to product and process innovation is higher. This work leads to some theoretical conclusions and implications for researchers and practitioners.
A global design principle for polysulfide electrocatalysis in lithium–sulfur batteries—A computational perspective
Authors: Abraham Akhil M. , Boteju Thilini , Ponnurangam Sathish , Thangadurai Venkataraman 
Published: May 2022

AbstractWidespread commercialization of high‐energy‐density lithium–sulfur (Li–S) batteries is difficult due to the lithium polysulfide, Li2Sn (n = 4, 6, 8), shuttle effect. Efficient adsorption/conversion of Li2Sn species on an electrocatalytic surface can suppress the shuttle effect. Modeling of the adsorption of Li2Sn species using density functional theory (DFT) calculations has contributed significantly toward an understanding of their anchoring mechanism at a surface. Different surfaces show a unique range of binding energies for faster Li2Sn adsorption/reaction kinetics. To predict the optimum binding energy zone, a systematic DFT study is performed on transition‐metal sulfide (TMS) surfaces including TiS2, VS2, NbS2, MoS2, WS2, and SnS2. The investigation revealed that the geometric properties at the anchoring site possibly regulate the adsorption energy of Li2Sn species. A geometry parameter, Gscore, is defined as a function of bond length and number of lithium‐atom interactions between the Li2Sn species and the binding surface. The design principle is extended to sulfur‐deficient (TMSs‐x) and edge‐exposed (TMS(100)) surfaces. The Gscore predicts the most effective binding energy zone distinctive to these materials—TMS (1.7–2.1 eV/Gscore ≥ 2.0), TMSs‐x (2.0–2.8 eV/Gscore ≥ 2.1), and TMS(100) (2.5–3.2 eV/Gscore ≥ 1.09).
Light‐intensity and moderate‐to‐vigorous intensity physical activity among older adult breast cancer survivors with obesity: A narrative review
Authors: Gordon Brett R. , Caru Maxime , Blair Cindy K. , Bluethmann Shirley M. , Conroy David E. , Doerksen Shawna E. , Hakun Jonathon G. , Sturgeon Kathleen M. , Potiaumpai Melanie , Sciamanna Christopher N. , Schmitz Kathryn H. 
Published: May 2022

AbstractBackgroundWith an aging population, rising incidence of breast cancer, improved survival rates, and obesity epidemic, there will be a growing population of older adult breast cancer survivors with obesity. This complex population, often with multimorbidity, is at risk for several poor health outcomes, including recurrence, cardiovascular disease, dementia, and diabetes, and a number of deleterious symptoms, including a worsened inflammatory profile, breast cancer‐ related lymphedema, mobility disability, cognitive impairment, anxiety, and depressive symptoms. A wealth of meta‐analytic and randomized controlled trial evidence show that adherence to World Health Organization and 2018 United States Physical Activity guidelines‐based levels of moderate‐to‐vigorous physical activity (MVPA) reduces risk of all‐cause mortality, and improves symptoms. However, few survivors engage in recommended levels of MVPA, and symptoms related to their multimorbidity may preclude engaging in sufficient levels of MVPA. Additional research of MVPA in this population is warranted; however, understudied light‐intensity physical activity (LIPA) may be a more pragmatic target than MVPA among this complex population facing extensive challenges meeting MVPA recommendations. Large benefits are likely to occur from increasing these survivors' total activity, and LIPA prescriptions may be a more pragmatic approach than MVPA to aid this transition.MethodsWe present a broad, narrative review of the evidence for MVPA and LIPA in this population on an array of health outcomes across the translational science spectrum (clinical, implementation, and public health), and identify a number of directions for future research focused on understanding the potential diverse health effects of LIPA.ConclusionAdditional LIPA research is warranted, as LIPA prescriptions may be a pragmatic strategy to effectively promote physical activity to this complex population.
Phytochemical, Chemotaxonomic and Bioinformatics Study on Laportea bulbifera (Urticaceae)
Authors: Lu Xuan , Zhao Yuxuan , Li Bo , Feng Weixing , Qi Junkai , Feng Baomin 
Published: May 2022

AbstractPhytochemical investigation of the aerial part of Laportea bulbifera (Siebold & Zucc.) Wedd. (L. bulbifera) showed the isolation of seventeen compounds, including five flavonoids (1–4 and 6), one terpenoid (5), five phenolic acids (7–11), one coumarin (12), two steroids (13–14), and three alkaloids (15–17). Structure elucidations of these compounds were performed on the basis of extensive NMR experiments and compared with the published data in the references. It is remarkable that compounds (3–5) were firstly isolated from the Urticaceae family, compounds (3–8, 11 and 15–17) were firstly obtained from genus Laportea. Furthermore, the result of the chemotaxonomic significance discussion showed that compounds (2–4) may can be served as compound fingerprints to distinguish between species of L. bulbifera and genus Urtica, and what’ more, we proposed a bold conjecture that isoflavones can distinguish between species of L. bulbifera and genus Urtica. At the same time, the molecular docking method was used to evaluate the inhibitory effect of these compounds on human steroid 5α‐reductase 2 (SRD5α2). The results showed that compounds (1–4 and 6) had better expected effects than the positive drug finasteride can by effectively binding to the active sites of SRD5α2. This study assisted in the future phytochemical and chemotaxonomic research on genus Laportea. Simultaneously, this research provided the theoretical evidence for the application of L. bulbifera in treating benign prostatic hyperplasia (BPH).
Suicidal attempt by disinfectant solution ingestion in case of opioid dependence
Authors: Koulaei Nejad Kiana , Ghasemzadeh Rahbardar Mahboobeh 
Published: May 2022

AbstractThe current study presents a rare case of an opioid dependence (46‐year‐old man) ingesting a disinfectant solution (Wavicide‐01; 2.65% glutaraldehyde solution, pH:6). The doctor intubated the patient and ordered bicarbonate for systemic acidosis, anti‐proton‐pump inhibitors (PPIs), and mechanical ventilation because the patient's breathing was irregular and the endoscopy revealed grade 1 and grade 2 burns all the way through the gastrointestinal tract up to the duodenum. As a result, ingestion of glutaraldehyde compounds should be closely monitored for laryngeal edema and metabolic acidosis, which can result in upper airway obstruction requiring immediate airway stabilization. Furthermore, a better understanding of the clinical epidemiology of suicide attempts could aid in the early identification of people that use opioids and are at high risk of suicide, as well as the development of suicide prevention strategies for this vulnerable population.
Molecular Ln(III)−H−E(II) Linkages (Ln=Y, Lu; E=Ge, Sn, Pb)
Authors: Widemann Max , Aicher Frederik S. W. , Bonath Martin , Eichele Klaus , Maichle‐Mössmer Cäcilia , Schubert Hartmut , Sirsch Peter , Anwander Reiner , Wesemann Lars 
Published: May 2022

AbstractFollowing the alkane‐elimination route, the reaction between tetravalent aryl tintrihydride Ar*SnH3 and trivalent rare‐earth‐metallocene alkyls [Cp*2Ln(CH{SiMe3}2)] gave complexes [Cp*2Ln(μ‐H)2SnAr*] implementing a low‐valent tin hydride (Ln=Y, Lu; Ar*=2,6‐Trip2C6H3, Trip=2,4,6‐triisopropylphenyl). The homologous complexes of germanium and lead, [Cp*2Ln(μ‐H)2EAr*] (E = Ge, Pb), were accessed via addition of low‐valent [(Ar*EH)2] to the rare‐earth‐metal hydrides [(Cp*2LnH)2]. The lead compounds [Cp*2Ln(μ‐H)2PbAr*] exhibit H/D exchange in reactions with deuterated solvents or dihydrogen.
Synthesis of 2,2‐Disubstituted 2H‐Chromenes through Carbon‐Carbon Bond Formation Utilizing a [1,2]‐Phospha‐Brook Rearrangement under Brønsted Base Catalysis
Authors: Kondoh Azusa , Terada Masahiro 
Published: May 2022

AbstractA new methodology for the synthesis of 2,2‐disubstituted 2H‐chromenes was developed by utilizing the [1,2]‐phospha‐Brook rearrangement under Brønsted base catalysis. Phosphazene P2‐tBu efficiently catalyzed the addition reaction of 4H‐chromen‐4‐ols containing a diethoxyphosphoryl group with α,β‐unsaturated ketones, which involved the catalytic generation of a carbanion through the [1,2]‐phospha‐Brook rearrangement and subsequent conjugate addition at the 2‐position to afford adducts possessing an alkenylphosphate moiety in a highly diastereoselective manner. Further transformation of the adducts based on a nickel‐catalyzed cross‐coupling reaction with arylzinc reagents provided densely functionalized 2,2‐disubstituted 2H‐chromenes.
Ammonia Borane, NH3BH3: A Threshold Photoelectron–Photoion Coincidence Study of a Potential Hydrogen‐Storage Material
Authors: Schleier Domenik , Gerlach Marius , Pratim Mukhopadhyay Deb , Karaev Emil , Schaffner Dorothee , Hemberger Patrick , Fischer Ingo 
Published: May 2022

AbstractWe have investigated the photoionization of ammonia borane (AB) and determined adiabatic ionization energy to be 9.26±0.03 eV for the X+ 2E←X 1A1 transition. Although the threshold photoelectron spectrum appears at first glance to be similar to the one of the isosteric ethane, the electronic situation differs markedly, due to different orbital energies. In addition, an appearance energy AE0K(NH3BH3, NH3BH2+)= 10.00±0.03 eV has been determined, corresponding to the loss of a hydrogen atom at the BH3‐site. From the data, a 0 K bond dissociation energy for the B−H bond in the cation of 71.5±3 kJ mol−1 was derived, whereas the one in the neutral compound has been estimated to be 419±10 kJ mol−1.
Prognostic value of RDW alone and in combination with NT‐proBNP in patients with heart failure
Authors: Liang Lin , Huang Liyan , Zhao Xuemei , Zhao Lang , Tian Pengchao , Huang Boping , Feng Jiayu , Zhang Jian , Zhang Yuhui 
Published: May 2022

AbstractBackgroundRed blood cell distribution width (RDW) and N‐terminal pro brain natriuretic peptide (NT‐proBNP) may predict the prognosis of heart failure (HF). However, the impact of combined RDW and NT‐proBNP levels as a prognostic marker of HF remains unclear and the significance of this combination at various time‐points has not been sufficiently studied.HypothesisRDW can predict prognosis in HF at various time‐points and combination with NT‐proBNP improves the prognostic value.MethodsPatients admitted to HF care unit of Fuwai Hospital CAMS&PUMC (Beijing, China) with a diagnosis of HF from November 2008 to November 2018 were analyzed retrospectively.ResultsIn total, 3231 patients with available RDW data at admission were evaluated (median age 58 years, 71.9% males, 39.7% coronary heart disease, 68.6% New York Heart Association [NYHA] III or IV). Median RDW and NT‐proBNP at admission were 13.4% (interquartile range [IQR]: 12.7%–14.5%), and 1723.00 pg/ml (IQR: 754.00–4006.25 pg/ml), respectively. During 2.9‐year median follow‐up, all‐cause death occurred in 1075 (33.27%) patients. Kaplan–Meier survival curve and Cox proportional‐hazard models, showed patients in the top quarter RDW had a 32.0% increased mortality compared to the bottom quarter (hazard ratio: 4.39, 95% confidence interval: 3.59–5.38; p <.001). The top quarter RDW retained independent prognostic value across HF with reduced ejection fraction [HFrEF], HF with mid‐range ejection fraction [HFmrEF], and HF with preserved ejection fraction [HFpEF] subgroups. Patients were subsequently divided into four groups by median RDW and NT‐proBNP. Comparison of Kaplan–Meier survival curves for various groups showed good risk stratification (p < .001).ConclusionsRDW is an independent predictor of mortality among patients with HF in the short‐, medium‐, and long‐term. Combination of RDW and NT‐proBNP improves the prognostic value. This is true across all clinical subtypes of heart failure (HFrEF, HFmrEF, HFpEF), and among most subgroups of patients with various comorbidities (infection, diabetes, hypertension).
The brain of the tree pangolin (Manis tricuspis). IX. The pallial telencephalon
Authors: Imam Aminu , Bhagwandin Adhil , Ajao Moyosore S. , Manger Paul R. 
Published: May 2022

AbstractA cyto‐, myelo‐, and chemoarchitectonic analysis of the pallial telencephalon of the tree pangolin is provided. As certain portions of the pallial telencephalon have been described previously (olfactory pallium, hippocampal formation, and amygdaloid complex), we focus on the claustrum and endopiriform nuclear complex, the white matter and white matter interstitial cells, and the areal organization of the cerebral cortex. Our analysis indicates that the organization of the pallial telencephalon of the tree pangolin is similar to that observed in many other mammals, and specifically quite similar to the closely related carnivores. The claustrum of the tree pangolin exhibits a combination of insular and laminar architecture, while the endopiriform nuclear complex contains three nuclei, both reminiscent of observations made in other mammals. The population of white matter interstitial cells resembles that observed in other mammals, while a distinct laminated organization of the intracortical white matter was revealed with parvalbumin immunostaining. The cerebral cortex of the tree pangolin presented with indistinct laminar boundaries as well as pyramidalization of the neurons in both layers 2 and 4. All cortical regions typically found in mammals were present, with the cortical areas within these regions often corresponding to what has been reported in carnivores. Given the similarity of the organization of the pallial telencephalon of the tree pangolin to that observed in other mammals, especially carnivores, it would be reasonable to assume that the neural processing afforded the tree pangolin by these structures does not differ dramatically to that of other mammals.
Plasmon Mediated Electron Transfer and Temperature Dependent Electron‐Phonon Scattering in Gold Nanoparticles Embedded in Dielectric Films
Authors: Ghorai Nandan , De Goutam , Ghosh Hirendra N. 
Published: May 2022

AbstractExcitation of localized surface plasmon resonance in metal nanoparticles (NPs) embedded in a glassy matrix generates hot electrons, which can be extracted for different optoelectronic applications. The insights of plasmon relaxation dynamics with varying surrounding dielectric environments and temperature dependence electron‐phonon scattering process in gold (Au) NPs are still not very clear. Here, we have employed ultrafast transient absorption (TA) spectroscopy to explore the hot plasmon mediated electron transfer (PMET) and electron‐phonon dynamics of photo‐excited Au NPs in glassy film matrix with variable SiO2/TiO2 compositions at cryogenic (5 K) to room temperature (300 K). Herein, we have chosen two pump excitation wavelengths (400 and 700 nm). The 400 nm excitation (d→sp) generates hot electron and the 700 nm excitation (sp→sp) provide information of direct plasmon relaxation. Drastic reduction of the transient signal of Au NPs in the high TiO2 content film as compared to pure SiO2 confirm hot electron transfer (HET) from Au plasmon to TiO2. Electron‐phonon scattering time constant (τe‐ph) of Au NPs in the glassy film is found to be faster in presence of TiO2 due to facile electron transfer/injection. Temperature dependent TA studies suggest that electron‐phonon scattering time decreases with temperature. These findings would assist to develop more advanced photo‐voltaic, opto‐electronic and quantum optic‐based devices using the plasmonic metal NPs.
A Study of the Functionalisation of BOPYIN Dyes: Synthesis and Photophysical Properties**
Authors: Liu Debao , Wang Xuan , Zhou Yongzhu , Hu Cong , Su Peng , Yan Jiaying , Zhang Nuonuo 
Published: May 2022

AbstractBorondifluoride‐3,3‐dimethyl‐2‐[2‐(2‐pyrrolyl) ethenyl] indole (BOPYIN), a seven‐membered, nonplanar boron complex, features typical photophysical properties, such as relatively large Stokes shift. Herein, a series of BOPYINs are prepared by a two‐step, one‐flask synthesis. Based on the modification position, these derivatives could be divided into three sections, including withdrawing substituted dyes, dyes with donating substitution on the pyrrole unit, and dyes with further π‐enlarged substitution on indole unit. The relationship between diverse modified structures and photophysical properties are systematically discussed by experiments and DFT calculations. This work illustrates that donating‐group modifications on pyrrole and π‐enlargement on the indole unit may promote the red shift of the photophysical spectra synergistically.
Preparation and Characterization of Orthorhombic AgMn Alloys by the Pulsed Laser Welding Technique
Authors: Khanfar Hazem K. , Qasrawi A. F. 
Published: May 2022

AbstractHerein, AgMn alloys are prepared by the pulsed laser welding technique in an argon atmosphere. The effect of the laser pulses width and stoichiometric composition of the alloys on the structural, compositional, morphological, and electrical properties are investigated. In contrast to the traditional preparation techniques which reveal cubic structure of AgMn alloys, the pulsed laser welding technique reveals the orthorhombic phase of the alloys. The lattice parameters of the orthorhombic phase of AgMn are . It is observed that pulse widths of 50 ms are the optimum from preparing these alloys. From an electrical point of view, the AgMn alloys exhibit negative dielectric constant and negative conductance effect in the microwave frequency domain. The impedance spectroscopy analyses in the frequency domain of 0.01–1.80 GHz have shown that AgMn alloys can be employed as band filters with return loss value of ≈16 dB. The features of the AgMn alloys which are achieved by the pulsed laser welding technique nominate them for use as negative capacitance and negative conductance transistors. These devices are suitable for noise reduction and parasitic capacitance cancellation.
Fgf8 dosage regulates jaw shape and symmetry through pharyngeal‐cardiac tissue relationships
Authors: Zbasnik Nathaniel , Dolan Katie , Buczkowski Stephanie A. , Green Rebecca M. , Hallgrímsson Benedikt , Marcucio Ralph S. , Moon Anne M. , Fish Jennifer L. 
Published: May 2022

AbstractBackgroundAsymmetries in craniofacial anomalies are commonly observed. In the facial skeleton, the left side is more commonly and/or severely affected than the right. Such asymmetries complicate treatment options. Mechanisms underlying variation in disease severity between individuals as well as within individuals (asymmetries) are still relatively unknown.ResultsDevelopmental reductions in fibroblast growth factor 8 (Fgf8) have a dosage dependent effect on jaw size, shape, and symmetry. Further, Fgf8 mutants have directionally asymmetric jaws with the left side being more affected than the right. Defects in lower jaw development begin with disruption to Meckel's cartilage, which is discontinuous. All skeletal elements associated with the proximal condensation are dysmorphic, exemplified by a malformed and misoriented malleus. At later stages, Fgf8 mutants exhibit syngnathia, which falls into two broad categories: bony fusion of the maxillary and mandibular alveolar ridges and zygomatico‐mandibular fusion. All of these morphological defects exhibit both inter‐ and intra‐specimen variation.ConclusionsWe hypothesize that these asymmetries are linked to heart development resulting in higher levels of Fgf8 on the right side of the face, which may buffer the right side to developmental perturbations. This mouse model may facilitate future investigations of mechanisms underlying human syngnathia and facial asymmetry.