bluuebunny/crossref_metadata_2025_split huggingface dataset:
SORA: Stellar occultation reduction and analysis
Authors: Gomes-Júnior A R , Morgado B E , Benedetti-Rossi G , Boufleur R C , Rommel F L , Banda-Huarca M V , Kilic Y , Braga-Ribas F , Sicardy B 
Published: January 2022

ABSTRACT
The stellar occultation technique provides competitive accuracy in determining the sizes, shapes, astrometry, etc., of the occulting body, comparable to in-situ observations by spacecraft. With the increase in the number of known Solar system objects expected from the LSST, the highly precise astrometric catalogs, such as Gaia, and the improvement of ephemerides, occultations observations will become more common with a higher number of chords in each observation. In the context of the Big Data era, we developed sora, an open-source python library to reduce and analyse stellar occultation data efficiently. It includes routines from predicting such events up to the determination of Solar system bodies’ sizes, shapes, and positions.
IL-37 blocks gouty inflammation by shaping macrophages into a non-inflammatory phagocytic phenotype
Authors: Zhao Li , Zhao Tianyi , Yang Xue , Cao Ling , Xu Rui , Liu Jiyu , Lin Cong , Yu Yiyun , Xuan Dandan , Zhu Xiaoxia , Liu Lei , Hua Yinghui , Deng Chunhui , Wan Weiguo , Zou Hejian , Xue Yu 
Published: January 2022

Abstract

Objective
Interleukin (IL)-37 is a natural suppressor of inflammation. Macrophages play an important role in acute gout flare by dominating the inflammation and spontaneous relief. We have reported that IL-37 could limit runaway inflammation in gout. Here we focus on whether IL-37 inhibits gouty inflammation by altering macrophage functions, and how it does so.

Methods
Macrophage functions were evaluated in terms of phagocytosis, pyroptosis, polarization and metabolism. Phagocytosis and polarization of macrophages were detected by side scattering and double-labelling induced nitrogen monoxide synthase (iNOS)/arginase-1 (Arg-1) using flow cytometry, respectively. Transcription of pyroptosis-related molecules was detected by qPCR. Metabolomics was performed by liquid chromatograph mass spectrometer. Human IL-37 knock-in mice and a model with point mutation (S9A) at mouse Gsk3b locus were created by CRISPR/Cas-mediated genome engineering. MSU was injected into the paws and peritoneal cavity to model acute gout. Vernier calliper was used to measure the thickness of the paws. The mice paws and human synovium tissues or tophi were collected for pathological staining. Peritoneal fluid of mice was used to enrich macrophages to detect polarization.

Results
IL-37 promoted non-inflammatory phagocytic activity of macrophages by enhancing phagocytosis of MSU, reducing transcription of pyroptosis-related proteins and release of inflammatory cytokines, protecting mitochondrial function, and mediating metabolic reprogramming in MSU-treated THP-1 cells. These multifaceted roles of IL-37 were partly depended on the mediation of glycogen synthase kinase-3β (GSK-3β).

Conclusions
Our study revealed that IL-37 could shape macrophages into a ‘silent’ non-inflammatory phagocytic fashion. IL-37 may become a potentially valuable treatment option for patients of chronic gout, especially for those with tophi.
Outpatient Cervical Ripening with Balloon Catheters
Authors: Pierce-Williams Rebecca , Lesser Henry , Saccone Gabriele , Harper Lorie , Chen Vicky , Sciscione Anthony , Kuper Spencer , Subramaniam Akila , Ehsanipoor Robert , Berghella Vincenzo 
Published: January 2022

OBJECTIVE:
To evaluate whether outpatient cervical ripening with a balloon catheter results in a shorter amount of time in the labor and delivery unit when compared with use in the inpatient setting.

DATA SOURCES:
PubMed, Scopus, Cochrane Library, and ClinicalTrials.gov were searched from their inception until December 2020. No restrictions for language or geographic location were applied.

METHODS OF STUDY SELECTION:
Using a predefined protocol and search strategy, 1,152 titles were identified and screened. Randomized controlled trials that compared outpatient and inpatient cervical ripening with balloon catheters were included.

TABULATION, INTEGRATION, AND RESULTS:
Data extraction and risk of bias assessments were performed by two reviewers. Meta-analysis was performed to produce mean difference for continuous data and risk ratio (RR) for dichotomous data, both with a 95% CI. The primary outcome was the amount of time from admission to the labor ward until delivery. Additional secondary maternal and neonatal outcomes were evaluated. Eight trials (740 patients) were included; six studies (571 patients) reported on our primary outcome. Compared with the inpatient group, outpatient balloon cervical ripening was associated with significantly less time in the labor and delivery unit (outpatient 16.3±9.7 hours vs inpatient 23.8±14.0 hours; mean difference −7.24 hours, 95% CI −11.03 to −3.34). There were no differences in total induction time or total hospital admission. The outpatient group was significantly less likely than the inpatient group to undergo cesarean delivery (21% vs 27%), RR 0.76 (95% CI 0.59–0.98). There were no differences in other maternal or neonatal outcomes. There were no deliveries outside of the hospital and no stillbirths.

CONCLUSION:
Outpatient balloon cervical ripening in low-risk patients is associated with a decreased amount of time from admission to labor and delivery until delivery by more than 7 hours and a significant 24% decreased risk of cesarean delivery. Outpatient balloon cervical ripening is a safe alternative for low-risk patients and has the potential for significant benefits to patients, and labor and delivery units.

SYSTEMATIC REVIEW REGISTRATION:
PROSPERO, CRD42019140503.
Variations in Low-Risk Cesarean Delivery Rates in the United States Using the Society for Maternal-Fetal Medicine Definition
Authors: Ouyang Lijing , Cox Shanna , Ferre Cynthia , Xu Likang , Sappenfield William M. , Barfield Wanda 
Published: January 2022

OBJECTIVE:
To assess variations in low-risk cesarean delivery rates in the United States using the Society for Maternal-Fetal Medicine (SMFM) definition of low-risk for cesarean delivery and to identify factors associated with low-risk cesarean deliveries.

METHODS:
From hospital discharge data in the 2018 National Inpatient Sample and State Inpatient Databases, we identified deliveries that were low-risk for cesarean delivery using the SMFM definition based on the International Classification of Diseases, Tenth Revision, Clinical Modification codes. We estimated national low-risk cesarean delivery rates overall and by patient characteristics, clinically relevant conditions not included in the SMFM definition, and hospital characteristics based on the nationally representative sample of hospital discharges in the National Inpatient Sample. Multivariate logistic regressions were estimated for the national sample to identify factors associated with low-risk cesarean delivery. We reported low-risk cesarean delivery rates for 27 states and the District of Columbia based on the annual state data that represented the universe of hospital discharges from participating states in the State Inpatient Databases.

RESULTS:
Of an estimated 3,634,724 deliveries in the 2018 National Inpatient Sample, 2,484,874 low-risk deliveries met inclusion criteria. The national low-risk cesarean delivery rate in 2018 was 14.6% (95% CI 14.4–14.8%). The rates varied widely by state (range 8.9–18.6%). Nationally, maternal age older than 40 years, non-Hispanic Black or Asian race, private insurance as primary payer, admission on weekday, obesity, diabetes, or hypertension, large metropolitan residence, and hospitals of the South census region were associated with low-risk cesarean delivery.

CONCLUSION:
Approximately one in seven low-risk deliveries was by cesarean in 2018 in the United States using the SMFM definition and the low-risk cesarean delivery rates varied widely by state.
Surgical Removal of Midurethral Sling in Women Undergoing Surgery for Presumed Mesh-Related Complications
Authors: Doyle Paula Jaye , Grimes Cara L. , Balk Ethan M. , Wieslander Cecilia , Richardson Monica , Mamik Mamta M. , Sleemi Ambereen , Alas Alexandriah , Kudish Bela , Walter Andrew J. , Aschkenazi Sarit , Mama Saifuddin , Foda Mohamed , Meriwether Kate V. 
Published: January 2022

OBJECTIVE:
To assess whether some, or all, of the mesh needs to be removed when a midurethral sling is removed for complications.

DATA SOURCES:
A systematic review and meta-analysis was conducted. MEDLINE, Cochrane, and ClinicalTrials.gov databases from January 1, 1996, through May 1, 2021, were searched for articles that met the eligibility criteria with total, partial, or a combination of anti-incontinence mesh removal.

METHODS OF STUDY SELECTION:
All study designs were included (N≥10), and a priori criteria were used for acceptance standards. Studies were extracted for demographics, operative outcomes, and adverse events. Meta-analysis was performed when possible.

TABULATION, INTEGRATION, AND RESULTS:
We double-screened 11,887 abstracts; 45 eligible and unique studies were identified. Thirty-five were single-group studies that evaluated partial mesh removal, five were single-group studies that evaluated total mesh removal, and five were studies that compared partial mesh removal with total mesh removal. All of the studies were retrospective in nature; there were no randomized controlled studies. Comparative studies demonstrated that partial mesh removal had lower rates of postoperative stress urinary incontinence (SUI) than total mesh removal (odds ratio 0.46, 95% CI 0.22–0.96). Single-group studies supported lower rates of postoperative SUI with partial mesh removal compared with total mesh removal (19.2% [95% CI 13.5–25.7] vs 48.7% [95% CI 31.2–66.4]). Both methods were similar with respect to associated pain, bladder outlet obstruction, mesh erosion or exposure, and lower urinary tract symptoms. Adverse events were infrequent.

CONCLUSION:
Postoperative SUI may be lower with partial mesh removal compared with total mesh removal. Other outcomes were similar regardless of the amount of mesh removed.

SYSTEMATIC REVIEW REGISTRATION:
PROSPERO, CRD 42018093099.
Association of Medicaid Expansion Under the Affordable Care Act With Perinatal Care Access and Utilization Among Low-Income Women
Authors: Sun Eric P. , Guglielminotti Jean , Chihuri Stanford , Li Guohua 
Published: January 2022

OBJECTIVE:
To synthesize the empirical research evidence about the association between Medicaid expansion under the Affordable Care Act (ACA) and increasing perinatal care access and utilization among low-income women.

DATA SOURCES:
We searched MEDLINE through PubMed (1966–present), EMBASE (Ovid), the Cumulative Index to Nursing and Allied Health (1982–present), PAIS Index (ProQuest), Web of Science (1900–present), and the Cochrane Central Register of Controlled Trials. Our review focuses on the association between Medicaid expansion under the ACA and perinatal care access and utilization, which cannot be subjected to randomized controlled trials, therefore ClinicalTrials.gov was not included in our search.

METHODS OF STUDY SELECTION:
A comprehensive search of the research literature was performed using Covidence. Studies were eligible if they were based on population data and research designs ensuring that the exposure (ie, Medicaid expansion under the ACA) preceded the perinatal care access or utilization outcome, had an appropriate comparison group, presented quantitative data, and examined pregnant or postpartum women. The search in six bibliographic databases returned 1,243 records, with 855 abstracts reviewed, 34 full-text articles screened for eligibility, and nine eligible studies included in the systematic review.

TABULATION, INTEGRATION, AND RESULTS:
Stata 16 software was used to generate summary estimates, forest plots, funnel plots, and heterogeneity statistics. Random effects modeling based on pooled data revealed that Medicaid expansion was associated with a 6.1% increase in Medicaid enrollment for pregnant women (95% CI 1.3–10.9%) and a 3.3% increase in perinatal care utilization (95% CI 0.2–6.3%).

CONCLUSION:
Medicaid expansion under the ACA is associated with a modest and statistically significant increase in perinatal care access and utilization among low-income women.
Impact of Glutathione S-Transferase Polymorphisms on Busulfan Pharmacokinetics and Outcomes of Hematopoietic Stem Cell Transplantation
Authors: Al-Riyami Intisar , Al-Khabori Murtadha , Al Balushi Khalid , Al-Zadjali Shoaib , Al-Rawahi Mohammed , Dennison David , Al-Hunaini Mohammed , Al-Rawas Abdulhakeem , Al-Moundhri Mansour 
Published: January 2022

Background:
Busulfan (Bu) is an alkylating drug used in many preparative regimens before hematopoietic stem cell transplantation (HSCT). It is conjugated in the liver mainly by glutathione S-transferase isoenzyme A1-1 (GSTA1). Genetic polymorphisms in these isoenzymes may affect the pharmacokinetics of Bu and the clinical outcomes of HSCT. This study aimed to assess the impact of glutathione S-transferase (GST) genetic polymorphisms on the clearance of Bu and the clinical outcomes of patients undergoing HSCT.

Methods:
This single-center retrospective study included patients who received IV Bu before HSCT at Sultan Qaboos University Hospital (SQUH), Oman from January 2003 to October 2016. Genotyping for polymorphisms was performed for GSTM1, GSTT1, GSTA1, and GSTP1. Each GST polymorphism was analyzed for its impact on Bu clearance and HSCT outcomes.

Results:
A total of 135 patients were included. The mean Bu clearance was 3.7 ± 0.98 mL/min/kg. Patients with GSTA1 A-513G heterozygosity (AG) were found to have a higher incidence of graft loss (P = 0.006). Homozygous double null of GSTM1 and GSTT1 was associated with a higher incidence of acute graft versus host disease (P = 0.04). Double non-null GSTM1 and GSTT1 and non-null GSTM1 increased the risk of mortality (P = 0.034 and 0.021, respectively).

Conclusions:

GST genotyping before HSCT may predict HSCT outcomes. The results of this preliminary retrospective study need to be confirmed in a larger prospective study.
Plasma and Platelet Transfusion Strategies in Critically Ill Children Following Severe Trauma, Traumatic Brain Injury, and/or Intracranial Hemorrhage: From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding
Authors: Russell Robert , Bauer David F. , Goobie Susan M. , Haas Thorsten , Nellis Marianne E. , Nishijima Daniel K. , Vogel Adam M. , Lacroix Jacques ,   for the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
Published: January 2022

Objectives:
To present consensus statements and supporting literature for plasma and platelet transfusions in critically ill children with severe trauma, traumatic brain injury, and/or intracranial hemorrhage from the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding.

Design:
Systematic review and consensus conference of international, multidisciplinary experts in platelet and plasma transfusion management of critically ill children.

Setting:
Not applicable.

Patients:
Critically ill neonates and children with severe trauma, traumatic brain injury, and/or intracranial hemorrhage.

Interventions:
None.

Measurements and Main Results:
A panel of eight experts developed expert-based statements for plasma and platelet transfusions in critically ill neonates and children with severe trauma, traumatic brain injury, and/or intracranial hemorrhage. These statements were reviewed and ratified by the 29 Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding experts. A systematic review was conducted using MEDLINE, EMBASE, and Cochrane Library databases, from inception to December 2020. Consensus was obtained using the Research and Development/University of California, Los Angeles Appropriateness Method. Results were summarized using the Grading of Recommendations Assessment, Development, and Evaluation method. We developed one good practice statement and six expert consensus statements.

Conclusions:
The lack of evidence precludes proposing recommendations on monitoring of the coagulation system and on plasma and platelets transfusion in critically ill pediatric patients with severe trauma, severe traumatic brain injury, or nontraumatic intracranial hemorrhage.
Oral Aversion in Infants With Congenital Heart Disease: A Single-Center Retrospective Cohort Study*
Authors: Goldstein Stephanie A. , Watkins Kimberly J. , Lowery Ray E. , Yu Sunkyung , Knight Rachel M. , Drayton Amy K. , Sayers Laura , Gaies Michael 
Published: January 2022

OBJECTIVES:
Neonates undergoing cardiac surgery are at risk for oral aversion (OA). OA is not well described outside of the index hospitalization and impacts patients and families. We evaluated the prevalence of OA at 1 year old after neonatal cardiopulmonary bypass (CPB) surgery.

DESIGN:
Retrospective cohort study.

SETTING:
Single quaternary care hospital.

SUBJECTS:
Our cohort included 157 neonates who underwent CPB surgery from 2014 to 2017 and had follow-up data available at 1 year old.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Three feeding experts reviewed the medical record to define children with OA; 30% of charts were evaluated in triplicate for validation. Neonates with and without OA were compared in univariate analysis, and risk factors for OA were explored in a limited multivariable analysis. OA was present at 1 year in 37 patients (23.6%) and other feeding difficulties were present in an additional 29 patients (18.5%). Thirty-eight patients (24.2%) had a feeding tube, including 12 (7.6%) with a gastrostomy tube. Factors associated with OA at 1 year included total ICU days, duration of mechanical ventilation, total number of nil per os days, and number of postoperative days (PODs) until oral feeding initiation (all p < 0.0001). Number of POD until oral feeding initiation remained independently associated with OA at 1 year in multivariable analysis (adjusted odds ratio, 1.08; 95% CI, 1.04–1.12; p < 0.0001). Infants with any oral intake at discharge had lower odds of OA at 1 year (0.21; 95% CI, 0.08–0.5; p = 0.0003). At hospital discharge, 132 patients (84.1%) were taking some oral feeds, and 128 patients (81.5%) received tube feeding.

CONCLUSIONS:
OA and other feeding difficulties are common at 1 year old in neonates undergoing CPB surgery. Delayed exposure to oral intake may be a modifiable risk factor for OA and efforts to improve early oral feeding could lead to better functional outcomes.
Evaluating Clinician Attitudes After Local Implementation of the Veterans Affairs Predictive Analytic Model for Suicide Prevention
Authors: Piccirillo Marilyn L. , Pruitt Larry D. , Reger Mark A. 
Published: January 2022

Objective:
The Recovery Engagement and Coordination for Health—Veterans Enhanced Treatment (REACH VET) program was launched in 2017 to identify Veterans at high risk for suicide and other adverse outcomes using predictive analytics. This quality improvement study evaluated the sustainment of the REACH VET program at a large Veterans Affairs health care system by assessing clinician attitudes.

Methods:
A mixed-methods approach was used to collect anonymous survey (N=35) and qualitative interview (n=12) data from Veterans Affairs REACH VET providers.

Results:
Survey findings demonstrated largely neutral to negative attitudes towards REACH VET, with the most notable responses indicating that REACH VET identified Veterans who were already perceived to be engaged in care. Interview findings reflected a variety of attitudes, including perceived lack of added value and pessimism regarding successful outreach. Clinicians reported that the program was values-consistent and had the potential to improve the quality of care.

Conclusions:
Results demonstrate the need for educational interventions and improved communication between local coordinators and clinicians. Clinicians rarely discussed fears about the algorithmic approach, but they highlighted concerns about the value that this approach added to their role. Future evaluations are needed to examine additional sustainment issues.
A Plausible Explanation of Increased Suicidal Behaviors Among Transgender Youth Based on the Interpersonal Theory of Suicide (IPTS): Case Series and Literature Review
Authors: Phillip Antonia , Pellechi Ashabari , DeSilva Roshi , Semler Keith , Makani Ramkrishna 
Published: January 2022

Background:
Growing data on suicidal behavior among members of the lesbian, gay, bisexual, transgender, queer, questioning, and other sexual/gender minority (LGBTQ+) communities, particularly in the transgender subgroup, demonstrate that there is a stark elevation in suicidality compared with rates in their cisgender counterparts. Among the available theories of suicide, the interpersonal theory of suicide (IPTS) is a plausible explanation for the increased suicidal behaviors among transgender youths.

Objective:
The objective of this study was to examine the pathologic basis of treatment-resistant suicidality in transgender youth despite favorable environments using the theoretical framework of the IPTS, supported by a literature review and case series.

Methods:
We conducted a literature review using PubMed and PsycInfo with key words suicidal ideation, suicidality, transgender, transgender youth, gender dysphoria, and interpersonal theory of suicide. Seventy-eight articles were retrieved, which were then narrowed down to 30 articles after non-English articles and irrelevant topics were excluded. The clinical presentations of 5 transgender youths, 11 to 17 years of age, were found to be correlated with relevant reports in the research literature, implying a plausible rationale for elevated rates of suicide. All patients and families supplied verbal consent for these case reports to be published.

Results:
Reasons for suicidal behavior among the patients included thwarted belongingness and perceived burdensomeness leading to perpetual suicidal behavior. The presence in these cases of the following contributing factors in the IPTS—thwarted belongingness, perceived burdensomeness, and acquired capability for suicide—suggests that such a basis exists. Perceived burdensomeness appears to have a greater correlation with developing suicidal behavior than thwarted belongingness alone, but the presence of both demonstrates the highest risk of suicidality in transgender youth. Transgender children and adolescents are at extremely high risk of suicidal behavior, but little research has been devoted to the etiology and plausible explanations for this elevated risk, despite growing awareness of and support for the problem. This review suggests further research is required on the triadic factor interactions of the IPTS model that could help us to better understand and intervene with this high-risk population.