bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revisiting Fara: Comparison of merged prospection results of diverse magnetometers with the earliest excavations in ancient Šuruppak from 120 years ago
Authors: Hahn Sandra E. , Fassbinder Jörg W. E. , Otto Adelheid , Einwag Berthold , Al‐Hussainy Abbas Ali 
Published: October 2022

AbstractAncient Šuruppak, today Fara, was one of the major Sumerian cities in Mesopotamia. It was situated along one of the ancient watercourses of the Euphrates River. Findings date it back to the Jemdet Nasr period around 3000 bcwith a continuous occupation until the end of the Ur III period around 2000 bc. Fara was first explored and excavated by the Deutsche Orient‐Gesellschaft in the years 1902 and 1903 under the direction of Walter Andrae. Multiple excavation trenches with lengths up to 900 m transect the 1 km2wide mound and are still visible today which enables us to georeference the excavation maps. Today, the 2.2 km2wide archaeological area is dry and without any vegetation. Thousands of deep looting pits are covering the majority of mound which not only destroyed its upper metres but also challenge the application of geophysical prospection methods and their interpretation. The magnetometer prospecting of selected areas on and around the mound was carried out with three devices, two total field magnetometers and one gradiometer. The individual survey areas were combined in post‐processing by applying a high‐pass filter on the total field data sets and multiplying the vertical gradiometer data sets by a factor of two. This approach provides visually uniform magnetograms, despite being obtained by different devices, which simplifies subsequent visual interpretation. These magnetograms enable us to review, and to extend the results of the old excavations. The comparison show a good correlation in accuracy to the old drawings and positive identification of the already excavated features with magnetometry. Highlights of the survey are the discovery of the city wall confirming its existence, the layout of a unique building complex in the centre of the mound, likely a temple, traces of canals inside the city and an evaluation of magnetometer prospection over a looted area.
Ni‐Catalyzed Regioselective C‐5 Halogenation of 8‐Aminoquinoline and Co‐Catalyzed Chelation Assisted C−H Iodination of Aromatic Sulfonamides with Molecular Iodine
Authors: Fernandes Rodney A. , Choudhary Priyanka 
Published: October 2022

AbstractA Ni(II)‐ and Co(II)‐catalyzed sequential iodination of sulfonamides using inexpensive and milder molecular iodine (I2) as an iodinating reagent is reported for the first time. The 8‐amino‐5‐iodoquinoline moiety prepared via nickel catalysis act as a directing group for second iodination by chelation assisted cobalt catalysis resulting in ortho‐iodinated arylsulfonamide products. This methodology has been elaborated to various value added products by coupling reactions.
Tuning the Red Emission to Instigate Intrinsic White‐Light Emission in Single‐Phase Phosphor with Excellent Color Rendering Index
Authors: Dehury Asish K. , Behera Santosh Kumar , Chirauri Satya Kamal , Basu Suddhasatwa , Chaudhary Yatendra S. 
Published: October 2022

AbstractThere is ever‐growing interest to develop intrinsic white light emitting single‐phase phosphors that have high CRI, devoid of bluish tinge, ease of synthesis and are scalable. Herein, manipulating vacuum pressure to instigate white light emission in Cu2+‐doped‐ZnS phosphors is reported. The detailed X‐ray diffraction and electron microscopy confirm the cubic phase of Cu2+‐doped‐ZnS phosphor having agglomerated particles (∼130–150 nm). The incorporation of Cu2+ in the ZnS lattice is substantiated by the anti‐Stokes shift of Raman peaks and shifting of XRD peaks to higher 2θ values. Upon increasing Cu2+ doping concentration, the resulted decrease in the FWHM of XRD peaks implies shrinkage of the ZnS lattice. Interestingly, by tailoring the excitation wavelength, the stoichiometry of dopant ion, and defect states by varying the vacuum pressure, the optimized ZSC‐3 (3% Cu2+‐doped‐ZnS) displays the origin of clear blue, green and red emission bands, consequently giving rise to white light emission (CIE values: 0.345:0398). The PLQY and average lifetime calculated for ZSC‐3 are 5.98% and 1.5 ms, respectively. Such intense white light emission prompted to fabricate a prototype using a 310 nm UV LED. It exhibits high CRI (97) and warm CCT (4538 K), meeting highly desired values for a white light‐emitting phosphor for different lighting and electroluminescence applications.
Determinants of firms' greenness towards sustainable development: A multi‐country analysis
Authors: Horbach Jens , Prokop Viktor , Stejskal Jan 
Published: October 2022

AbstractA higher greenness of firms is crucial for the mitigation of climate change and other environmental pollution problems. This paper analyses the drivers of a greening of firms from a theoretical and empirical perspective. Three theoretical concepts—the stakeholder theory, the institutional theory and the resource‐based view—contribute to identifying the determinants of firms' greenness. In our empirical analysis based on recent World Bank data, greenness is measured by different environmentally related measures firms adopted over the preceding 3 years, such as more climate‐friendly energy generation, waste minimisation and the improvement of lighting systems. The results of probit and negative binomial regressions show that a high affectedness by environmental regulation triggers firms' greenness. In addition to this ‘forced greenness’, the results demonstrate that innovative firms are more likely to realise environmentally related measures. This finding also holds for firms affected by extreme weather events. A highly competitive environment is negatively connected with greenness. The corporate social responsibility of family‐owned firms seems to be higher than non‐family‐owned firms.
Ultrasound‐guided injection of the long head of the biceps tendon sheath with concomitant subacromial bursa injection through the same needlestick
Authors: Pujalte George , Hudspeth Loren J. , Troyer Wesley D. , Shapiro Shane A. 
Published: October 2022

AbstractSonography and specific shoulder positions allow for injections into both the long head of the biceps tendon sheath (LHBTS) and the subacromial space (SS) with one needlestick. We validated this technique using cadavers. An experienced proceduralist injected latex solution into 12 unembalmed cadaveric shoulders, aiming for the LHBTS and SS, using an ultrasound‐guided injection technique that employs a single‐needle entry point. An experienced surgeon dissected each specimen and graded latex location as: (1) completely accurate (in both the SS and LHBTS); (2) partially accurate (in either the SS or LHBTS); (3) accurate with overflow (in both locations, but also elsewhere); (4) partially accurate with overflow (in either location, but also somewhere else); or (5) completely inaccurate (no latex in either location). All 12 ultrasound‐guided injections using the technique accurately placed latex into both LHBTS and SS (100% accuracy). Latex was also found in adjacent regions after two (17%) injections: one within the shoulder joint and one within the deltoid musculature. This newly described technique allows highly accurate access to the LHBTS and SS with single‐needle entry. This technique could become a favored alternative to subjecting patients to two needlesticks and preparing separate injections to address often concomitant pathologies.
Increasing equitable access to telehealth oncology care in the COVID‐19 National Emergency: Creation of a telehealth task force
Authors: Worster Brooke , Waldman Lauren , Garber Gregory , Zhan Tingting , Lopez AnaMaria , Trachtenberg Olivia , Handley Nathan , Rising Kristin L. , Csik Valerie , Leader Amy 
Published: October 2022

AbstractIntroductionTelehealth (TH) utilization in cancer care prior to COVID‐19 was variable. Research highlights disparities in access determined by socioeconomic factors including education, income, race, and age. In response to COVID‐19 and these disparities, we assessed the impact of a personalized digital support structure, the Telehealth Task Force (TTF), to reduce disparities in TH.MethodsWe performed a retrospective review of cohorts between January 1, 2020 and August 30, 2020: Pre (TH use with basic telephone support), Intervention (TH access with TTF), and Post (TH access after TTF initiation and educational material dissemination). Data collected included successful TH access, health literacy (HL), and Area Deprivation Index, a ranking of neighborhoods by socioeconomic disadvantage (ADI). The data were analyzed in univariate ordinary least squares model and adjacent categories ratio model using statistical software R to understand the relationship between TTF, HL, ADI, and TH access.ResultsWe included 555 patients from January 1, 2020 to August 30, 2020 (90 preintervention, 194 intervention, and 271 postintervention), excluding patients without ADI/HL. TTF support successfully engaged older, racially, and socioeconomically diverse patients in TH; ADI is significantly higher in the postintervention group vs. preintervention (mean difference = 7.66, 95% CI 1.00–4.32, p = 0.024) and more patients had low HL during intervention compared with preintervention (adjacent categories ratio = 0.62, 95% CI 0.41–0.93, p = 0.021).DiscussionCOVID‐19 created an immediate need for TH. Implementation of the TTF helped close the digital divide, increasing TH access for vulnerable patients. Attention to digital readiness can mitigate disparities in access to care. Future research should explore the implementation of widespread routine digital support initiatives.
Long noncoding RNA HULC regulates the NF‐κB pathway and represents a promising prognostic biomarker in liver cancer
Authors: Liu Shihai , Huttad Lakshmi , He Guifang , He Weitai , Liu Changchang , Cai Duo , Chen Hao , Qiu Jing 
Published: October 2022

AbstractBackgroundLong noncoding RNAs (lncRNAs) are involved in a diverse array of biological processes. While lncRNAs are commonly upregulated in hepatocellular carcinoma (HCC), the specific regulatory roles they play in this oncogenic context require further study and clarification. Although HULC (lncRNA highly upregulated in liver cancer) is involved in disease pathogenesis, its precise role in this context remains unclear.MethodsHere, we have explored the mechanistic relevance of HULC expression by assessing its expression in patient samples. The importance of this lncRNA in the onset and progression of HCC was investigated through in vitro approaches including Western blotting, quantitative PCR, Transwell assays, electron microscopy, wound healing assays, and real‐time cell analysis (RTCA). Additionally, the in vivo functions of this lncRNA were assessed using an orthotopic HCC xenograft in nude mouse model system.ResultsHULC was identified as a lncRNA that is highly upregulated in human liver tumors. In vitro, HULC was able to promote HCC malignancy, although its excess overexpression also led robust autophagic induction, promoting the increased expression of autophagy‐associated genes including LC3 and Beclin‐1. At a mechanistic level, HULC was able to promote the phosphorylation of p65 and IkBkB thus enhancing autophagy by increasing LC3II levels in a manner dependent upon the NF‐κB pathway. HULC downregulation was also linked to impaired orthotopic HCC tumor growth in vivo. The link between HULC and autophagy may play a role in disease progression.ConclusionsThese results suggest that HULC is an oncogenic lncRNA, and may thus offer value as a prognostic biomarker and promoter of HCC development, in addition to being a potential therapeutic target in this cancer type.
Preoperative systemic inflammation response index is an independent prognostic marker for BCG immunotherapy in patients with non‐muscle‐invasive bladder cancer
Authors: Ye Kun , Xiao Ming , Li Zitaiyu , He Kancheng , Wang Jinhua , Zhu Liang , Xiong Wei , Zhong Zhaohui , Tang Yuxin 
Published: October 2022

AbstractBackgroundThe Systemic Inflammatory Response Index (SIRI) is a novel prognostic biomarker based on peripheral blood counts of neutrophils, monocytes, and lymphocytes. Recent evidence suggests that it is associated with poor prognosis in various cancers. However, the predictive value of the SIRI in non‐muscle‐invasive bladder cancer (NMIBC) patients treated with intravesical Bacillus Calmette‐Guerin (BCG) immunotherapy remains elusive. Therefore, this study aimed to evaluate the potential of SIRI as a prognostic factor in these patients.MethodsA total of 540 patients with NMIBC who underwent BCG immunotherapy following transurethral resection of bladder tumor (TURBT) were enrolled in this study. Using receiver operating characteristic (ROC) curves and the Youden index, patients were divided into high and low SIRI groups based on the cutoff values. Univariable and multivariable logistic regression analyses were performed to identify independent predictors of BCG non‐response. Thereafter, propensity score matching (PSM) was used to eliminate bias due to confounding factors between the low and high SIRI groups. Finally, the Kaplan–Meier method was used to compare recurrence‐free survival (RFS) and progression‐free survival (PFS) between the two groups.ResultsMultivariable logistic regression analysis revealed that high SIRI (p = 0.001), high MLR (p = 0.015), and high tumor pathological T stage (p = 0.015) were significantly correlated with non‐response to BCG therapy. In addition, both RFS and PFS were shorter in the high SIRI group than in the other group before and after PSM (both p < 0.05). Collectively, our results indicate that the combination of tumor pathological T staging and the SIRI can enhance the predictive power of BCG response.ConclusionPretreatment peripheral blood SIRI can be employed to predict the response to BCG immunotherapy and the prognosis of NMIBC patients. Taken together, the combination of T stage and SIRI demonstrated robust performance in predicting the response to BCG immunotherapy in NMIBC patients.
Variability in the Essential Oil Composition ofAchillea erba‐rottasubsp.moschata(Wulfen) I. Richardson Growing in the Eastern Italian Alps
Authors: Fusani Pietro , Aiello Nicola , Biazzi Elisa , Tava Aldo 
Published: October 2022

AbstractAchillea erba‐rottasubsp.moschata(Wulfen) I. Richardson is endemic of the Central Alps and distributed in several Italian Regions, where is used for its medicinal and aromatic properties. Nine wild populations of the species were characterized for their essential oil content and composition. In total 45 components were detected of which 40 were identified, accounting from 96.3 % to 98.8 % of the total oil. Monoterpenes represented the main class of compounds (from 84 % to 90.9 %), beingcis‐thujone (from 1.1 % to 48.4 %), camphor (from 1.8 % to 36.9 %), 1,8‐cineole (from 4.9 % to 23.4 %),trans‐thujone (from 2.2 % to 33.9 %) andp‐cymene (from 1.8 % to 4.8 %) the most abundant ones. The relative amount of chamazulene, detected in some accessions, was here reported for the first time in this species. High variability in the essential oil composition resulted among the investigated accessions, which were grouped by multivariate analysis into four main clusters, in some cases according to their site of origin. Beyond their possible chemo‐systematic significance, the obtained results represent useful indications for the selection of interesting chemotypes within the species, especially in the perspective of its future cultivation.
Painful shoulder and scapula as initial presentation of advanced lung adenocarcinoma
Authors: Cabrera‐Cardozo Fernando , Martínez‐Ávila María Cristina , Hernández‐Blanquisett Abraham , Quintero‐Carreño Valeria , Álvarez‐Londoño Angelina 
Published: October 2022

AbstractLung adenocarcinoma is a common cancer; even though it has a strong association with previous smoking, there has been described nonsmokers‐related cases. Symptoms varies from asymptomatic to hemoptysis or pleural effusion. We describe a case of a patient who presented with painful scapula as primary manifestation of advanced pulmonary malignancy.
G‐type Halohydrin Dehalogenases Catalyze Ring Opening Reactions of Cyclic Epoxides with Diverse Anionic Nucleophiles**
Authors: Solarczek Jennifer , Kaspar Felix , Bauer Pia , Schallmey Anett 
Published: October 2022

AbstractHalohydrin dehalogenases are promiscuous biocatalysts, which enable asymmetric ring opening reactions of epoxides with various anionic nucleophiles. However, despite the increasing interest in such asymmetric transformations, the substrate scope of G‐type halohydrin dehalogenases toward cyclic epoxides has remained largely unexplored, even though this subfamily is the only one known to display activity with these sterically demanding substrates. Herein, we report on the exploration of the substrate scope of the two G‐type halohydrin dehalogenases HheG and HheG2 and a newly identified, more thermostable member of the family, HheG3, with a variety of sterically demanding cyclic epoxides and anionic nucleophiles. This work shows that, in addition to azide and cyanide, these enzymes facilitate ring‐opening reactions with cyanate, thiocyanate, formate, and nitrite, significantly expanding the known repertoire of accessible transformations.
Catalyst‐Free Regio‐ and Diastereoselective Synthesis of Heterocyclic Nucleosides in the Eco‐friendly Solvent 2‐Methyltetrahydrofuran†
Authors: Gu Xiaodong , Du Qingwei , Song Weijian , Wang Jun Joelle 
Published: October 2022

Comprehensive SummaryAn efficient and practical synthesis of heterocyclic nucleosides is developed by a catalyst‐free highly regioselective and diastereoselective [3+2] annulation of α‐purine‐substituted acrylates with nitrones. The reaction operates with excellent functional group tolerance, very mild reaction conditions, and with the green, sustainable, and eco‐friendly 2‐methyltetrahydrofuran (2‐MeTHF) as solvent. Compared with other reactions of electron‐deficient olefin dipolarophiles with nitrones, different regioselective cycloaddition products were observed in this work. This 1,3‐dipolar cycloaddition reaction gives a series of isoxazolidinyl nucleosides in good to excellent yields with promising applications in biochemistry and medicinal chemistry.
The burden of chronic rhinosinusitis with nasal polyps and its relation to asthma in Finland
Authors: Toppila‐Salmi Sanna , Hällfors Jenni , Aakko Juhani , Mannerström Bettina , Nieminen Kaisa , Telg Gunilla , Lehtimäki Lauri 
Published: October 2022

AbstractBackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is commonly associated with asthma. Treatment of CRSwNP includes intranasal and systemic corticosteroids, with non‐responsive patients commonly considered for endoscopic sinus surgery (ESS). This nationwide register‐based study evaluated the incidence, prevalence, and treatment burden of CRSwNP in Finland, and their association with the presence and severity of comorbid asthma.MethodsElectronic health records of patients diagnosed with CRSwNP between 1.1.2012 and 31.12.2018 in Finnish specialty and primary care were included in the study. The patients were divided into subgroups based on presence, severity, and control of asthma: no asthma, mild to moderate asthma, severe controlled asthma, and severe uncontrolled asthma. A mean cumulative count of ESS was calculated over time per subgroup.ResultsThe prevalence of CRSwNP increased from 602.2 to 856.7 patients per 100,000 population between years 2012 and 2019 (p < 0.001). A total of 18,563 patients (59.9% male) had incident CRSwNP between 2012 and 2019, with 27% having asthma, 6% having severe asthma, and 1.5% having severe uncontrolled asthma. In the no asthma, severe controlled asthma, and severe uncontrolled asthma subgroups, systemic corticosteroids were used by 54.1%, 94.9% and 99.3% (p < 0.001), respectively, while the ESS count 3 years post diagnosis was 0.49, 0.68 and 0.80, respectively.ConclusionsThe prevalence of CRSwNP showed a significant increase in the recent decade in Finland. Comorbid asthma, and in particular severe asthma, increased the probability of receiving systemic corticosteroids and undergoing ESS. Thus, improved management of CRSwNP in patients with comorbid asthma is urgently needed.
Ab Initio Study of H‐Bond Dynamics in Three‐Component Crystals Comprising (DABCOH+)nPolycationic Chains
Authors: Malec Leszek M. , Brela Mateusz Z. , Stadnicka Katarzyna M. 
Published: October 2022

AbstractIn this work, the dynamic character of hydrogen‐bond (H‐bond) networks in two three‐component crystals comprising polycationic chains was described. The first studied system was 1,4‐diazabicyclo[2.2.2]octan‐1‐ium (DABCOH+) sulfamate monohydrate, known for its large negative linear compressibility. The second analyzed material was the newly obtained polar salt co‐crystal: 1,4‐diazabicyclo[2.2.2]octan‐1‐ium sulfamate urea. X‐ray diffraction measurements enabled us to study the H‐bond systems in both crystals using the graph set analysis. Obtained structures served as the initial models for Born‐Oppenheimer molecular dynamics computations. A detailed study of intermolecular interactions and power spectra was conducted. The analysis of time and space correlations between the changes in H‐bonds enabled the detection of proton transfer occurring in both systems at 300 K. Further study of those dynamic phenomena was done using the Energy Decomposition Analysis for selected trajectory fragments. Our work should improve the understanding of dielectric and ferroelectric properties of hybrid organic‐inorganic materials.
Informed consent for psychotherapy: Ethical illusion or clinical reality? A survey about psychotherapists' attitudes and practices in Germany
Authors: Gerke Leonie , Meyrose Ann‐Katrin , Nestoriuc Yvonne 
Published: October 2022

AbstractObjectiveThis study aimed to assess clinicians' attitudes and their current clinical practices regarding informed consent for psychotherapy.MethodA convenience sample of N = 530 clinicians in Germany (n = 418 licensed psychotherapists and n = 112 postgraduate psychotherapy trainees) took part in an online survey.ResultsMost clinicians (84%) reported obtaining informed consent for psychotherapy in their daily routine. However, many psychotherapists felt unsure about satisfactorily fulfilling the legal (63%) and ethical obligations (52%). The two most frequently reported components of information disclosure related to explaining the terms and conditions of psychotherapy (96%) and the psychotherapeutic approach (91%). Providing information about mechanisms of psychotherapy (33%) and the role of expectations (30%) were least practiced. One in five psychotherapists reported not informing clients about potential risks and side effects. A considerable proportion reported concern about inducing anxiety in patients by disclosing information about risks and side effects (52%).ConclusionsAlthough obtaining informed consent for psychotherapy seems to be the rule rather than the exception in clinical practice, the quality of its implementation in terms of legal, ethical and clinical demands remains questionable. Training psychotherapists in providing comprehensive informed consent enables informed decision‐making and might have a positive influence on treatment expectations and outcomes.