bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of slip boundary conditions, magnetic force, and porous medium on blood flow of Jeffrey fluid
Authors: Nazeer Mubbashar , Ahamdi Ahmad Aziz Al , Alzaed Ali Nasser , Alwetaishi Mamdooh , Nazir Muhammad Waqas , Khan Muhammad Ijaz 
Published: July 2022

AbstractIn this study, the comparative study of the peristaltic flow of Newtonian and non‐Newtonian fluids under the consideration of the magnetic field in the porous inclined channel is investigated. The effects of velocity slip and convective boundary conditions are also considered. Moreover, the variable liquid properties are also taken. The mathematical model is developed with the help of the Jeffrey fluid model in the form of partial differential equations. After that, convert them into dimensional form by using the dimensionless quantities. The resultant system of equations is solved through the perturbation method and presented the solution of velocity, temperature, and concentration in analytical form. The impact of physical parameters on the velocity, temperature, and concentration profiles are highlighted with the help of the graphs. The outcomes revealed that the magnetic parameter slows down the velocity of the fluid while the Darcy number enhanced the velocity and temperature distribution and suppressed the concentration profile.
Bullöse Arzneimittelreaktion nach Gabe von Pembrolizumab – 2 Fallberichte
Authors: Golle L. , Michl C. , Kreft B. 
Published: July 2022

ZusammenfassungZu den schweren, blasenbildenden Arzneimittelreaktionen an der Haut gehören das Stevens-Johnson-Syndrom (SJS) und die toxisch epidermale Nekrolyse (TEN). Allopurinol, Antikonvulsiva, Sulfonamidantibiotika und nichtsteroidale Antirheumatika vom Oxicam-Typ sind wiederholt als Auslöser beschrieben. Zunehmend rücken auch Immuntherapien als Auslöser schwerer Hautreaktionen in den Fokus. Vorgestellt werden 2 Patienten mit bullösen Hauterscheinungen nach Gabe des Checkpointinhibitors Pembrolizumab. Da das klinische Bild nicht immer eine zweifelsfreie Einordnung zulässt, ist eine histologische Mitbeurteilung vielfach unverzichtbar.
Soy product intake and risk of incident disabling dementia: the JPHC Disabling Dementia Study
Authors: Murai Utako , Sawada Norie , Charvat Hadrien , Inoue Manami , Yasuda Nobufumi , Yamagishi Kazumasa , Tsugane Shoichiro ,   For the JPHC Study Group
Published: July 2022

Abstract
Purpose
We evaluated the association between total soy, soy product (natto, miso and tofu) and isoflavone intake and incident disabling dementia in a Japanese population.

Methods
We conducted a population-based prospective study in 18,991 men and 22,456 women. Intake of soy products and isoflavone was calculated using a validated food frequency questionnaire when participants were 45–74 years old (1995 and 1998). Incident disabling dementia was defined by the daily living disability status related to dementia in the long-term care insurance program of Japan from 2006 to 2016. Multivariate hazard ratios (HRs) and 95% confidence intervals (CIs) of disabling dementia were calculated by quintiles of total soy, individual soy product and isoflavone intake, using Cox proportional hazard regression models.

Results
Total soy product intake was not associated with disabling dementia risk in both men and women. By individual soy products, natto intake was marginally inversely associated with disabling dementia in women (trend P = 0.050). When we stratified by age, this inverse association was clearer in women aged under 60 years (multivariate HR for the highest versus lowest quintile was 0.78, 95% CI 0.59–1.04, trend P = 0.020 for those aged under 60 years and 0.90, 95% CI 0.77–1.05, trend P = 0.23 for those aged 60 years and older, respectively). Any soy product or isoflavone intake was not associated with disabling dementia risk in men.

Conclusions
Although total soy product intake was not associated with disabling dementia risk, natto intake may contribute to reducing the risk of disabling dementia in women, especially in those aged under 60 years.
Dissociation of liner from cup in THA: does liner damage affect the risk of dissociation?
Authors: Beckmann Nicholas Andreas , Schonhoff Mareike , Bastian Johannes Dominik , Renkawitz Tobias , Jaeger Sebastian 
Published: July 2022

Abstract
Introduction
A rare catastrophic failure of modular component Total Hip Arthroplasty is dissociation between liner and cup, which has been associated with component malposition and/or impingement and seems to be more frequently associated with the Pinnacle system. The goal of this study was to evaluate the resistance of a polyethylene liner to lever-out-forces of the Pinnacle locking mechanism and the locking mechanisms of two other current cup/liner systems using a standardized testing method (ASTM).

Materials and methods
Five of each of the following cups were evaluated with their corresponding polyethylene liners: Pinnacle Multihole cup with and without intact anti-rotation tabs (ART’s); Allofit-S-Alloclassic and Plasmafit Plus7 cups. The ASTM test set-up was used to evaluate the lever-out force resulting in liner dissociation for each construct.

Results
The Pinnacle construct with intact ARTs required the greatest force (F) to achieve dissociation (263.2 ± 79.2 N) followed by the Plasmafit Plus7 (185.8 ± 36.9 N) and the Allofit-S (101.4 ± 35.3 N) constructs, respectively. However, after removal of the ARTs, the Pinnacle system required the least force to achieve dissociation (75.1 ± 22.2 N) (p < 0.001).

Conclusions
The intact Pinnacle system appeared the most stable in lever-out tests when compared to the other systems. However, after removal of the ARTs, the Pinnacle system required the least force for dissociation, consistent with locking mechanism failure, and suggesting that the ARTs are a critical component of the locking mechanism. Our findings are consistent with the clinical experience of dissociated Pinnacle constructs displaying damaged or missing ARTs, and that damage to these may increase risk of liner dissociation.
A link between age, affect, and predictions?
Authors: Trapp Sabrina , Guitart-Masip Marc , Schröger Erich 
Published: July 2022

AbstractThe prevalence of depressive symptoms decreases from late adolescence to middle age adulthood. Furthermore, despite significant losses in motor and cognitive functioning, overall emotional well-being tends to increase with age, and a bias to positive information has been observed multiple times. Several causes have been discussed for this age-related development, such as improvement in emotion regulation, less regret, and higher socioeconomic status. Here, we explore a further explanation. Our minds host mental models that generate predictions about forthcoming events to successfully interact with our physical and social environment. To keep these models faithful, the difference between the predicted and the actual event, that is, the prediction error, is computed. We argue that prediction errors are attenuated in the middle age and older mind, which, in turn, may translate to less negative affect, lower susceptibility to affective disorders, and possibly, to a bias to positive information. Our proposal is primarily linked to perceptual inferences, but may hold as well for higher-level, cognitive, and emotional forms of error processing.
Community-based accompaniment for adolescents transitioning to adult HIV care in urban Peru: a pilot study
Authors: Vargas Valentina , Wong Milagros , Rodriguez Carly A. , Sanchez Hugo , Galea Jerome , Ramos Alicia , Senador Liz , Kolevic Lenka , Matos Eduardo , Sanchez Eduardo , Errea Renato A. , Ramos Karen , Beckhorn Catherine , Lindeborg Andrew , Benites Carlos , Lecca Leonid , Shin Sonya , Franke Molly F. 
Published: July 2022

AbstractWe piloted a community-based intervention to improve outcomes among adolescents living with HIV who were transitioning to adult-oriented care in Lima, Peru. We assessed feasibility and potential effectiveness, including within-person changes in self-reported adherence, psychosocial metrics (NIH Toolbox), and transition readiness (“Am I on TRAC” questionnaire, “Got Transition” checklist). From October 2019 to January 2020, we enrolled 30 adolescents (15–21 years). The nine-month intervention consisted of logistical, adherence and social support delivered by entry-level health workers and group sessions to improve health-related knowledge and skills and social support. In transition readiness, we observed within-person improvements relative to baseline. We also observed strong evidence of improvements in adherence, social support, self-efficacy, and stress, which were generally sustained three months post-intervention. All participants remained in treatment after 12 months. The intervention was feasible and potentially effective for bridging the transition to adult HIV care. A large-scale evaluation, including biological endpoints, is warranted.
Benevolent Sexism and the Traditional Sexual Script as Predictors of Sexual Dissatisfaction in Heterosexual Women from the U.S.
Authors: Bonell Sarah , Lee Harrison , Pearson Samuel , Harris Emily , Barlow Fiona Kate 
Published: July 2022

AbstractWomen report lower sexual satisfaction than men. Given that sexual dissatisfaction adversely impacts health and well-being, it is imperative that we investigate why women are sexually dissatisfied. In the present study, we explored whether women’s benevolently sexist attitudes might predict their sexual dissatisfaction. In a sample of 308 (Mage = 38.09) heterosexual American women who had previously had sex with a man, we hypothesized that women’s benevolent sexism would be associated with an increased adoption of the traditional sexual script (i.e., an increased propensity for submissiveness and passivity during sex) and that this, in turn, would be associated with increased sexual dissatisfaction. We also hypothesized that the relationship between the adoption of the traditional sexual script and sexual dissatisfaction would be moderated by the degree to which participants enjoy submissiveness. Overall, we did not find support for our model: benevolent sexism did not predict sexual dissatisfaction. However, we did find that adopting the traditional sexual script was predictive of sexual dissatisfaction for women who do not enjoy submissiveness. These findings contribute to an emerging literature pertaining to women’s sexual health. Specifically, results suggest that benevolent sexism does not contribute to women’s experiences of sexual dissatisfaction. Instead, they suggest that sexual dissatisfaction in women may (in part) be driven by their engagement in sexual roles that do not align with their sexual preferences. Theoretical and clinical implications for these findings are discussed.
Manipulation at optimum locations for maximum force transmission with mobile robots under environmental disturbances
Authors: Tugal Harun , Cetin Kamil , Petillot Yvan , Dunnigan Matthew , Erden Mustafa Suphi 
Published: July 2022

AbstractRemote manipulation plays a key role for applications in hazardous conditions, yet designing a robust controller enabling safe interaction with unknown environment and under the influence of disturbances is a challenge. In this study, we propose effective control and optimization methods for mobile robotic manipulator systems that can increase effort transmission to a task in desired directions. The vehicle position is optimized by utilizing constrained particle swarm optimization where the objective is to enhance directional manipulability of the robotic arm within the system. A forward dynamic controller is implemented to eliminate undesired excessive motions near singular joint configurations. A reset control algorithm along with an admittance type controller are developed for stable interaction with an unknown object under environmental disturbances. The experimentally validated results show that the proposed method phase out undesired position disturbances and increase the directional manipulability for the required task enabling augmented effort transmission for the task execution.
Teacher Autonomy Support and Internalizing Problems of Adolescents from Divorced and Intact Families: Moderation by Personality Typologies
Authors: Lan Xiaoyu , Mastrotheodoros Stefanos 
Published: July 2022

AbstractThe present research compared internalizing problems of adolescents who experienced parental divorce with those of adolescents who remained in intact families. Furthermore, this research investigated the association of teacher autonomy support with adolescents’ internalizing problems for the whole sample and further ascertained whether this association was moderated by distinctive personality profiles using a person-centered approach and family structures (divorced vs. intact families). A sample of 2756 Chinese adolescents (8.5% from divorced families), aged 13–18 years, participated in the present research. They completed a set of self-reported questionnaires during school hours. Results based on ANCOVA showed that adolescents who experienced parental divorce reported higher internalizing problems than did those who remained in intact families. Moreover, latent profile analysis revealed three personality profiles: psychopathic (22.7%), normative (56.4%), and resilient (20.9%). In addition, teacher autonomy support was negatively related to adolescents’ internalizing problems in the overall sample. However, interaction analyses further exhibited that this association was insignificant for psychopathic adolescents who experienced parental divorce. The current findings indicate that although teacher autonomy support may protect adolescents from internalizing problems, psychopathic adolescents whose parents got divorced should be paid exceptional attention by mental health professionals and school counselors.
Alendronate-loaded gelatin microparticles as templating agents for macroporous magnesium phosphate-based bone cements
Authors: Gelli Rita , Sforzi Lucrezia , Montanari Francesco , Ridi Francesca , Baglioni Piero 
Published: July 2022

AbstractMagnesium phosphate-based cements (MPCs) have recently attracted great attention as materials for bone repair. However, the lack of macroporosity, fundamental for cells permeation and bone ingrowth, is one of the main limitations hampering MPCs full exploitation. In this work gelatin microparticles are exploited as templating agents for the creation of macroporosities in MPCs. In addition, gelatin particles were loaded with a well-recognized drug for the treatment of osteoporosis, alendronate, to locally release the therapeutic agent. Gelatin microparticles of different size were prepared with a simple water-in-oil emulsion method and included in MPCs at various concentrations. The properties of both the MPCs and the final material were characterized by assessing the composite in terms of injectability, setting time, infrared spectroscopy, scanning electron microscopy and confocal Raman microscopy. The MPC-gelatin composites were then incubated in water at physiological temperature, to promote the dissolution of the gelatin, obtain a macroporous cement, and release gelatin and alendronate. The obtained results show that gelatin microparticles have a twofold action as they allow for the formation of MPC with an interconnected and hundreds of µm-sized porosity and the local release of alendronate, resulting in a material with ideal features for bone repair.Graphical abstract
Striving for Personal Perfection: Rudolf Allers’s Psycho-Ethic-Metaphysical Approach to Character and Self-Improvement
Authors: García-Alandete Joaquín 
Published: July 2022

AbstractThe Viennese psychiatrist Rudolf Allers was one of the principal authors that studied character and contributed to understanding its development and education, including the neurotic character. His psychological observations were based on his own clinical experience, his individual psychology, phenomenological and existential philosophies, and, above all, the doctrine of the Fathers of the Catholic Church and Thomas Aquinas. This paper presents Allers’s main ideas about self-improvement as a process of personal changing toward self-perfection, that is, toward the best version of oneself. For Allers, self-perfection implies the modification of insane aspects of character such as egocentricity, pride, and untidy love for oneself, which are the most important impediments to self-improvement.
50 Years of the steric-blocking mechanism in vertebrate skeletal muscle: a retrospective
Authors: Parry David A. D. 
Published: July 2022

AbstractFifty years have now passed since Parry and Squire proposed a detailed structural model that explained how tropomyosin, mediated by troponin, played a steric-blocking role in the regulation of vertebrate skeletal muscle. In this Special Issue dedicated to the memory of John Squire it is an opportune time to look back on this research and to appreciate John’s key contributions. A review is also presented of a selection of the developments and insights into muscle regulation that have occurred in the years since this proposal was formulated.
Histone demethylase KDM5B catalyzed H3K4me3 demethylation to promote differentiation of bone marrow mesenchymal stem cells into cardiomyocytes
Authors: Wang Zhen , Zhong Chenlu , Li Hongxiao 
Published: July 2022

Abstract
Background
Studies have shown that histone H3 methylation is involved in regulating the differentiation of Bone Marrow Mesenchymal Stem Cells (BMSCs). KDM5B can specifically reduce the level of histone 3 lysine 4 trimethylation (H3K4me3), thereby activating the expression of related genes and participating in biological processes such as cell differentiation, embryonic development and tumor formation. Whether KDM5B is involved in the regulation of BMSCs differentiation into cardiomyocytes through the above manner has not been reported.

Objective
To investigate the effect of KDM5B on the induction and differentiation of swine BMSCs into myocardial cells in vitro.

Methods
Swine bone marrow BMSCs were isolated and cultured, and the overexpression, interference expression and blank vector of KMD5B were constructed and transfected by lentivirus. BMSCs was induced to differentiate into cardiomyocytes by 5-azacytidine (5-AZA) in vitro, and the differentiation efficiency was compared by immunofluorescence, RT-PCR, Western Blot and whole-cell patch clamp detection.

Result
Compared with the control group, the expression levels of histone H3K4me3 and pluripotency gene Nanog in KDM5B overexpression group were significantly decreased, while the expression level of key myocardial gene HCN4 and myocardial marker gene α-Actin and cTNT were significantly increased, and the Na+ current density on the surface of differentiated myocardial cell membrane was significantly increased. Meanwhile, the corresponding results of the KDM5B silent expression group were just opposite.

Conclusions
It indicated that enhanced KDM5B expression could promote the differentiation of BMSCs into cardiomyocytes and improve the differentiation efficiency by controlling H3K4 methylation levels.
Mothers’ Domestic Responsibilities and Well-Being During the COVID-19 Lockdown: The Moderating Role of Gender Essentialist Beliefs About Parenthood
Authors: Thorsteinsen Kjærsti , Parks-Stamm Elizabeth J. , Kvalø Marie , Olsen Marte , Martiny Sarah E. 
Published: July 2022

AbstractThe present work investigates how the increased domestic responsibilities created by the Spring 2020 lockdown of the COVID-19 pandemic in Norway and gender ideologies relate to the well-being of mothers with elementary school children. In June 2020, we conducted a cross-sectional online study including current and retrospective measures with 180 mothers (Mage = 39.96 years,SD = 6.11) of elementary school children across Norway. First, in line with earlier research on the strain of the pandemic on parents, and especially mothers, we found that Norwegian mothers’ well-being during the lockdown significantly declined compared to before the lockdown (both measured retrospectively). Furthermore, mothers’ well-being after the Spring 2020 lockdown did not immediately return to pre-lockdown levels. Finally, we predicted that gender ideologies (i.e., essentialist beliefs about parenthood) would exacerbate the negative impact of increased domestic responsibilities (i.e., childcare and housework) on mothers’ well-being (i.e.,higher standard-higher stresshypothesis). As predicted, for mothers who more strongly endorsed the belief that mothers are instinctively and innately better caretakers than fathers, perceptions of increased domestic responsibilities were associated with lower well-being post-lockdown. These findings point to the specific challenges mothers face in times of crisis, and the importance of addressing and confronting seemingly benevolent ideologies about motherhood that place additional burdens on women.
Rate of Change of Large-Scale Solar-Wind Structure
Authors: Owens Mathew J. , Chakraborty Nachiketa , Turner Harriet , Lang Matthew , Riley Pete , Lockwood Mike , Barnard Luke A. , Chi Yutian 
Published: July 2022

AbstractQuantifying the rate at which the large-scale solar-wind structure evolves is important for both understanding the physical processes occurring in the corona and for space-weather forecast improvement. Models of the global corona and heliosphere typically assume that the ambient solar-wind structure is steady and corotates with the Sun, which is generally expected to be more valid at solar minimum than solar maximum, but this has not been well tested. Similarly, assimilation of solar-wind observations into models requires quantitative knowledge of how the reliability of the observations changes with age. In this study we examine 25 years of near-Earth in situ solar-wind observations and 45 years of observation-constrained solar-wind simulations to determine how much the 1-AU solar-wind speed, $V$
V
, and radial magnetic-field component, $B_{R}$

B
R

, vary between consecutive Carrington rotations (CRs). For the in situ spacecraft observations, we find the rate of change of $V$
V
and $B_{R}$

B
R

is similar during solar maximum and minimum, particularly when transient interplanetary coronal mass ejections are removed from the data. This is somewhat counter to expectations. Conversely, the rate of change in $V$
V
and $B_{R}$

B
R

obtained from global heliospheric simulations is strongly correlated with the solar cycle, with the corona and heliosphere being more variable at solar maximum, as expected. Limiting the analysis of the simulations to the solar equatorial region, however, strongly reduces the difference between solar maximum and minimum, bringing the result into close agreement with the in situ observations. This latitudinal sensitivity is explained in terms of the global solar-wind structure over the solar cycle. For the purposes of assimilating in-ecliptic solar-wind observations, we suggest the uncertainty in $V$
V
should increase by around 3 km s−1 per day since the observation was made and 0.1 nT per day for $B_{R}$

B
R

. For observations made at higher latitude, the effect of observation age will be solar-cycle dependent.
Belief merging in absence of reliability information
Authors: Liberatore Paolo 
Published: July 2022

AbstractMerging beliefs depends on the relative reliability of their sources. When this is information is absent, assuming equal reliability is unwarranted. The solution proposed in this article is that every reliability profile is possible, and only what holds according to all of them is accepted. Alternatively, one source is completely reliable, but which one is not specified. These two cases motivate two existing forms of merging: maxcons-based merging and disjunctive merging.