bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor-associated immune cell infiltrate density in penile squamous cell carcinomas
Authors: Hladek Luca , Bankov Katrin , von der Grün Jens , Filmann Natalie , Demes Melanie , Vallo Stefan , Wild Peter J. , Winkelmann Ria 
Published: January 2022

AbstractPenile squamous cell carcinomas are rare tumor entities throughout Europe. Early lymphonodal spread urges for aggressive therapeutic approaches in advanced tumor stages. Therefore, understanding tumor biology and its microenvironment and correlation with known survival data is of substantial interest in order to establish treatment strategies adapted to the individual patient. Fifty-five therapy naïve squamous cell carcinomas, age range between 41 and 85 years with known clinicopathological data, were investigated with the use of tissue microarrays (TMA) regarding the tumor-associated immune cell infiltrate density (ICID). Slides were stained with antibodies against CD3, CD8 and CD20. An image analysis software was applied for evaluation. Data were correlated with clinicopathological characteristics and overall survival. There was a significant increase of ICID in squamous cell carcinomas of the penis in relation to tumor adjacent physiological tissue. Higher CD3-positive ICID was significantly associated with lower tumor stage in our cohort. The ICID was not associated with overall survival. Our data sharpens the view on tumor-associated immune cell infiltrate in penile squamous cell carcinomas with an unbiased digital and automated cell count. Further investigations on the immune cell infiltrate and its prognostic and possible therapeutic impact are needed.
Executive functioning and serum lipid fractions in Parkinson’s disease—a possible sex-effect: the PACOS study
Authors: Luca Antonina , Monastero Roberto , Cicero Calogero Edoardo , Baschi Roberta , Donzuso Giulia , Mostile Giovanni , Restivo Vincenzo , Di Giorgi Lucia , Caccamo Maria , Zappia Mario , Nicoletti Alessandra 
Published: January 2022

AbstractThe association between dyslipidemia and cognitive performance in Parkinson’s disease (PD) patients still needs to be clarified. Aim of the study was to evaluate the presence of possible associations between serum lipids fractions and executive dysfunction also exploring the sex-specific contribute of lipids level on cognition. Patients from the PACOS cohort, who underwent a complete serum lipid profile measures (total cholesterol-TC, low-density lipoprotein cholesterol-LDL, high-density lipoprotein cholesterol-HDL and triglycerides-TG) were selected. Adult Treatment Panel III guidelines of the National Cholesterol Education Program were used to classify normal/abnormal lipid fractions. Executive functioning was assessed with the Frontal Assessment Battery (FAB). Logistic regression was performed to assess associations between lipids fractions and FAB score. Correlations between lipids fractions and FAB score were explored. Sex-stratified analysis was performed. Three hundred and forty-eight PD patients (148 women; age 66.5 ± 9.5 years; disease duration 3.9 ± 4.9 years) were enrolled. Women presented significantly higher TC, LDL and HDL than men. In the whole sample, any association between lipid profile measures and FAB score was found. Among women, a positive association between hypertriglyceridemia and FAB score under cutoff was found (OR 3.4; 95%CI 1.29–9.03; p value 0.013). A statistically significant negative correlation was found between the FAB score and triglyceride serum levels (r = − 0.226; p value 0.005). Differently, among men, a statistically significant negative association between hypercholesterolemia and FAB score under cutoff (OR 0.4; 95%CI 0.17–0.84; p value 0.018) and between high LDL levels and FAB score under cutoff (OR 0.4; 95%CI 0.18–0.90; p value 0.027) were found. Our data suggest a sex-specific different role of lipids in executive functioning.
Lack of discrimination of sex and maturity of conspecifics in the copulation attempts of the male stalk-eyed fly, Sphyracephala detrahens (Diptera: Diopsidae)
Authors: Kudo Ayumi , Fujii Takeshi , Ishikawa Yukio 
Published: January 2022

AbstractAmong insects, males have evolved the ability to discriminate potential mates to avoid vain mating attempts. In Diptera, courtship and mating behaviors of species that do not discriminate potential mates have rarely been studied. In this study, we investigated copulation attempts of the stalk-eyed fly, Sphyracephala detrahens males, which do not engage in any observable pre-copulatory courtship behavior. We found that sexually mature males attempted to copulate with mature males and immature adults of both sexes, as frequently as with mature females. Successful copulation only occurred with mature females. Immature females rejected mounting males by vibrating their bodies and immature and mature males by incurving their abdomen downward. Comparison of the cuticular hydrocarbon components of individuals of different sexes and maturity levels indicated that the cuticular hydrocarbon profiles were similar regardless of the sex and sexual maturity. Therefore, we suggest that visual or chemical information are of little use for males S. detrahens in discriminating receptive conspecific mates. Since elaborate mate discrimination behaviors lead to additional time and energy costs when discrimination is difficult, S. detrahens may increase reproductive success simply by increasing the number of copulation attempts. Digital video images related to this article are available at http://www.momo-p.com/showdetail-e.php?movieid=momo211123sd01a, http://www.momo-p.com/showdetail-e.php?movieid=momo211123sd02a, http://www.momo-p.com/showdetail-e.php?movieid=momo211123sd03a, and http://www.momo-p.com/showdetail-e.php?movieid=momo211123sd04a.
Silicon fertilisation affects morphological and immune defences of an insect pest and enhances plant compensatory growth
Authors: Islam Tarikul , Moore Ben D. , Johnson Scott N. 
Published: January 2022

AbstractHerbivorous insects have evolved various anti-predator defences, including morphological, behavioural, and immune defences, which can make biocontrol of herbivorous pests challenging. Silicon (Si) accumulation in plants is a potent physical defence against mandibulate insects. However, it remains uncertain how Si affects the anti-predator defences of insect herbivores and plant defences following herbivory. We grew the model grass, Brachypodium distachyon, hydroponically with (+Si) or without (–Si) Si and investigated the plant-mediated effects of Si on the anti-predator defences of the cotton bollworm, Helicoverpa armigera, integrating morphological (i.e. integument resistance and thickness), behavioural, and immune defences. We also examined the effects of Si on plant compensatory growth and leaf trichome production. Larval growth, leaf consumption, and integument resistance were lower when feeding on +Si plants compared to when feeding on –Si plants. Larval integument thickness, defensive behaviours, haemocyte density, and lysozyme-like activity in the haemolymph were unaffected by Si. Larvae fed on +Si plants had higher haemolymph phenoloxidase (PO) and total-PO activities than larvae fed on –Si plants, although this did not enhance the melanisation response of larvae. Furthermore, Si supplies increased plant compensation for herbivory and constitutive trichome production, whereas herbivory induced trichome production only on –Si plants. We provide the first evidence for plant-mediated effects of Si on anti-predator defences of an insect herbivore. We suggest that the lower integument resistance of larvae when feeding on Si-supplemented plants could contribute to their vulnerability to natural enemies and that high PO activity may impose fitness costs (e.g. delayed development).
Longitudinal strain by speckle tracking and echocardiographic parameters as predictors of adverse cardiovascular outcomes in chronic Chagas cardiomyopathy
Authors: Echeverría Luis Eduardo , Rojas Lyda Z. , Rueda-Ochoa Oscar L. , Gómez-Ochoa Sergio Alejandro , Mayer Miguel A. , Becerra-Motta Lisbeth Paola , Luengas Carlos , Chaves Angel M. , Rodríguez Jaime A. , Morillo Carlos A. 
Published: January 2022

AbstractTo analyze the prognostic value of left ventricular global longitudinal strain (LV-GLS) and other echocardiographic parameters to predict adverse outcomes in chronic Chagas cardiomyopathy (CCM). Prospective cohort study conducted in 177 consecutive patients with different CCM stages. Transthoracic echocardiography measurements were obtained following the American Society of Echocardiography recommendations. By speckle-tracking echocardiography, LV-GLS was obtained from the apical three-chamber, apical two-chamber, and apical four-chamber views. The primary composite outcome (CO) was all-cause mortality, cardiac transplantation, and a left ventricular assist device implantation. After a median follow-up of 42.3 months (Q1 = 38.6; Q3 = 52.1), the CO incidence was 22.6% (95% CI 16.7–29.5%, n = 40). The median LV-GLS value was − 13.6% (Q1 =  − 18.6%; Q3 =  − 8.5%). LVEF, LV-GLS, and E/e′ ratio with cut-off points of 40%, − 9, and 8.1, respectively, were the best independent CO predictors. We combined these three echocardiographic markers and evaluated the risk of CO according to the number of altered parameters, finding a significant increase in the risk across the groups. While in the group of patients in which all these three parameters were normal, only 3.2% had the CO; those with all three abnormal parameters had an incidence of 60%. We observed a potential incremental prognostic value of LV-GLS in the multivariate model of LVEF and E/e′ ratio, as the AUC increased slightly from 0.76 to 0.79, nevertheless, this difference was not statistically significant (p = 0.066). LV-GLS is an important predictor of adverse cardiovascular events in CCM, providing a potential incremental prognostic value to LVEF and E/e′ ratio when analyzed using optimal cut-off points, highlighting the potential utility of multimodal echocardiographic tools for predicting adverse outcomes in CCM.
Use of GIS and machine learning to predict disease in shrimp farmed on the east coast of the Mekong Delta, Vietnam
Authors: Khiem Nguyen Minh , Takahashi Yuki , Yasuma Hiroki , Oanh Dang Thi Hoang , Hai Tran Ngoc , Ut Vu Ngoc , Kimura Nobuo 
Published: January 2022

AbstractDiseases in shrimp farms in the Mekong Delta of Vietnam cause significant crop losses and are therefore of great concern to producers. Once a pond becomes infected, it is difficult to prevent spread of the disease to nearby shrimp farming areas. Thus, predicting the occurrence of disease is an essential part of reducing the risk for shrimp farmers. In this study, we applied an integrated geographic information system and machine learning system to predict three serious diseases of shrimp, namely, acute hepatopancreatic necrosis, white spot syndrome disease, and Enterocytozoon hepatopenaei infection, based on data collected from shrimp farms in the Tra Vinh, Bac Lieu, Soc Trang, and Ca Mau provinces of Vietnam. We first constructed a map showing the distribution of these diseases using the locations of affected farms, and then we conducted spatial analysis to acquire the geographical features of the affected locations. This latter information was combined with environmental factors and clinical signs to form the set of independent variables affecting the outbreak of diseases. The neural network model outperformed the logistic regression, random forest, and gradient boosting methods in terms of predicting infection to estimate the probability of disease occurrence in farmed areas. Acute hepatopancreatic necrosis disease infected farms downstream of the Co Chien and Hau Rivers of Tra Vinh and west of Ca Mau. Enterocytozoon hepatopenaei infection is distributed in Soc Trang Province, while white spot syndrome virus has spread to the coastal districts of Soc Trang and Bac Lieu Provinces, where it is highly associated to water from a complex canal system.
Conceptual design of sonic boom stealth supersonic transports
Authors: Sun Yicheng , Smith Howard 
Published: January 2022

AbstractThis paper introduces a supersonic transport aircraft design model developed in the GENUS aircraft conceptual design environment. A conceptual design model appropriate to supersonic transports with low-to-medium-fidelity methods are developed in GENUS. With this model, the authors reveal the relationship between the sonic boom signature and the lift and volume distributions and the possibility to optimise the lift distribution and volume distribution together so that they can cancel each other at some region. A new inspiring design concept—sonic boom stealth is proposed by the authors. The sonic boom stealth concept is expected to inspire the supersonic aircraft designers to design low-boom concepts through aircraft shaping and to achieve low ground impacts. A family of different classes of supersonic aircraft, including a single-seat supersonic demonstrator (0.47 psf), a 10-passenger supersonic business jet (0.90 psf) and a 50-seat supersonic airliner (1.02 psf), are designed to demonstrate the sonic boom stealth design principles. Although, there are challenges to balance the volume with packaging and control requirements, these concepts prove the feasibility of low-boom low-drag design for supersonic transports from a multidisciplinary perspective.
An approach for comparing agricultural development to societal visions
Authors: Helfenstein Julian , Diogo Vasco , Bürgi Matthias , Verburg Peter H. , Schüpbach Beatrice , Szerencsits Erich , Mohr Franziska , Siegrist Michael , Swart Rebecca , Herzog Felix 
Published: January 2022

AbstractThere is broad agreement that agriculture has to become more sustainable in order to provide enough affordable, healthy food at minimal environmental and social costs. But what is “more sustainable”? More often than not, different stakeholders have opposing opinions on what a more sustainable future should look like. This normative dimension is rarely explicitly addressed in sustainability assessments. In this study, we present an approach to assess the sustainability of agricultural development that explicitly accounts for the normative dimension by comparing observed development with various societal visions. We illustrate the approach by analyzing farm- and landscape-scale development as well as sustainability outcomes in a Swiss case study landscape. Observed changes were juxtaposed with desired changes by Avenir Suisse, a liberal think tank representing free-market interests; the Swiss Farmers Association, representing a conservative force; and Landwirtschaft mit Zukunft, an exponent of the Swiss agroecological movement. Overall, the observed developments aligned most closely with desired developments of the liberal think-tank (72%). Farmer interviews revealed that in the case study area farms increased in size (+ 57%) and became more specialized and more productive (+ 223%) over the past 20 years. In addition, interpretation of aerial photographs indicated that farming became more rationalized at the landscape level, with increasing field sizes (+ 34%) and removal of solitary field trees (− 18%). The case study example highlights the varying degrees to which current developments in agriculture align with societal visions. By using societal visions as benchmarks to track the progress of agricultural development, while explicitly addressing their narratives and respective systems of values and norms, this approach offers opportunities to inform also the wider public on the extent to which current developments are consistent with different visions. This could help identify mismatches between desired and actual development and pave the way for designing new policies.
Exploring the political pulse of a country using data science tools
Authors: Folgado Miguel G. , Sanz Veronica 
Published: January 2022

AbstractIn this paper we illustrate the use of Data Science techniques to analyse complex human communication. In particular, we consider tweets from leaders of political parties as a dynamical proxy to political programmes and ideas. We also study the temporal evolution of their contents as a reaction to specific events. We analyse levels of positive and negative sentiment in the tweets using new tools adapted to social media. We also train a Fully-Connected Neural Network (FCNN) to recognise the political affiliation of a tweet. The FCNN is able to predict the origin of the tweet with a precision in the range of 71–75%, and the political leaning (left or right) with a precision of around 90%. This study is meant to be viewed as an example of how to use Twitter data and different types of Data Science tools for a political analysis.
Forschungspartizipation von Kindern zwischen Minimalbeteiligung und Entscheidungsmacht: Forschungsethische Herausforderungen und Perspektiven der Forschungssubjekte auf Forschung in Kindertagesstätten
Authors: Rupprecht Beatrice , Lattner Katrin 
Published: January 2022

ZusammenfassungDer Beitrag geht der Frage nach, in wieweit Kinder im Rahmen von Forschungsprojekten in Kitas beteiligt werden. Zur Beantwortung der Frage werden die Daten von zwei Studien herangezogen, die im Projekt „Forschung trifft Kita“ erhoben wurden. Die Ergebnisse der Interviews mit Kindern und die Ergebnisse der deutschlandweiten Befragung von pädagogischen Fach- und Leitungskräften zeigen, dass die Mitwirkungsmöglichkeiten von Kindern derzeit noch stark eingeschränkt werden. Im Kontext der Bewertung der ethischen Strenge der in Kitas durchgeführten Forschungsprojekte wird für Partizipation als ergänzendes Ethikkriterium plädiert.
Violent Resistance
Authors: Jentzsch Corinna 
Published: January 2022

Why do communities form militias to defend themselves against violence during civil war? Using original interviews with former combatants and civilians and archival material from extensive fieldwork in Mozambique, Corinna Jentzsch's Violent Resistance explains the timing, location and process through which communities form militias. Jentzsch shows that local military stalemates characterized by ongoing violence allow civilians to form militias that fight alongside the government against rebels. Militias spread only to communities in which elites are relatively unified, preventing elites from coopting militias for private gains. Crucially, militias that build on preexisting social conventions are able to resonate with the people and empower them to regain agency over their lives. Jentzsch's innovative study brings conceptual clarity to the militia phenomenon and helps us understand how wartime civilian agency, violent resistance, and the rise of third actors beyond governments and rebels affect the dynamics of civil war, on the African continent and beyond. This title is available as open access on Cambridge Core.
Beamforming Seizures from the Temporal Lobe Using Magnetoencephalography
Authors: Garcia Dominguez Luis , Tarazi Apameh , Valiante Taufik , Wennberg Richard 
Published: January 2022

ABSTRACT:Background:Surgical treatment of drug-resistant temporal lobe epilepsy (TLE) depends on proper identification of the seizure onset zone (SOZ) and differentiation of mesial, temporolimbic seizure onsets from temporal neocortical seizure onsets. Noninvasive source imaging using electroencephalography (EEG) and magnetoencephalography (MEG) can provide accurate information on interictal spike localization; however, EEG and MEG have low sensitivity for epileptiform activity restricted to deep temporolimbic structures. Moreover, in mesial temporal lobe epilepsy (MTLE), interictal spikes frequently arise in neocortical foci distant from the SOZ, rendering interictal spike localization potentially misleading for presurgical planning.Methods:In this study, we used two different beamformer techniques applied to the MEG signal of ictal events acquired during EEG-MEG recordings in six patients with TLE (three neocortical, three MTLE) in whom the ictal source localization results could be compared to ground truth SOZ localizations determined from intracranial EEG and/or clinical, neuroimaging, and postsurgical outcome evidence.Results:Beamformer analysis proved to be highly accurate in all cases and was able to identify focal SOZs in mesial, temporolimbic structures. In three patients, interictal spikes were absent, too complex for dipole modeling, or localized to anterolateral temporal neocortex distant to a mesial temporal SOZ, and thus unhelpful in presurgical investigation.Conclusions:MEG beamformer source reconstruction is suitable for analysis of ictal events in TLE and can complement or supersede the traditional analysis of interictal spikes. The method outlined is applicable to any type of epileptiform event, expanding the information value of MEG and broadening its utility for presurgical recording in epilepsy.
Expression and Prognostic Value of CD80 and CD86 in the Tumor Microenvironment of Newly Diagnosed Glioblastoma
Authors: Ahmed Mohammed H. , Hernández-Verdin Isaias , Bielle Franck , Verreault Maïté , Lerond Julie , Alentorn Agusti , Sanson Marc , Idbaih Ahmed 
Published: January 2022

ABSTRACT:Background:Strategies to modulate the tumor microenvironment (TME) have opened new therapeutic avenues with dramatic yet heterogeneous intertumoral efficacy in multiple cancers, including glioblastomas (GBMs). Therefore, investigating molecular actors of TME may help understand the interactions between tumor cells and TME. Immune checkpoint proteins such as a Cluster of Differentiation 80 (CD80) and CD86 are expressed on the surface of tumor cells and infiltrative tumor lymphocytes. However, their expression and prognostic value in GBM microenvironment are still unclear.Methods:In this study, we investigated, in a retrospective local discovery cohort and a validation TCGA dataset, expression of CD80 and CD86 at mRNA level and their prognostic significance in response to standard of care. Furthermore, CD80 and CD86 at the protein level were investigated in the discovery cohort.Results:Both CD80 and CD86 are expressed heterogeneously in the TME at mRNA and protein levels. In a univariate analysis, the mRNA expression of CD80 and CD86 was not significantly correlated with OS in both local OncoNeuroTek dataset and TCGA datasets. CD80 and CD86 mRNA high expression was significantly associated with shorter progression free survival (PFS) (p < 0.05). These findings were validated using the TCGA cohort; higher CD80 and CD86 expressions were correlated with shorter PFS (p < 0.05). In multivariate analysis, CD86 mRNA expression was an independent prognostic factor for PFS in the TCGA dataset only (p < 0.05).Conclusion:CD86 could be used as a potential biomarker for the prognosis of GBM patients treated with immunotherapy; however, additional studies are needed to validate these findings.