bluuebunny/crossref_metadata_2025_split huggingface dataset:
The COMT Genetic Factor Regulates Chemotherapy-Related Prospective Memory Impairment in Survivors With HER2−/+ Breast Cancer
Authors: Li Wen , Zhang Qianqian , Cai Yinlian , Chen Tingting , Cheng Huaidong 
Published: February 2022

BackgroundPrevious findings indicated that polymorphism in gene catechol-O-methyltransferase (COMT) had been linked to chemotherapy-related cognitive impairment (CRCI). Nevertheless, the motivation of COMT polymorphisms in regulating cognitive impairment in breast cancer survivors with disparate status of human epidermal growth factor receptor 2 (HER2) was still vague.ObjectiveThe current research aimed to evaluate the regulation of the risk by COMT genotype on CRCI in breast cancer survivors with disparate status of HER2.MethodsBreast cancer survivors (103 with HER2− and 118 with HER2+) underwent neuropsychological tests before and after chemotherapy, containing event- and time-based prospective memory (EBPM and TBPM). Three single-nucleotide polymorphisms (SNPs) were estimated by providing peripheral blood, containing COMT (rs165599, rs737865, and rs4680).ResultsThe EBPM and TBPM performances was lower as compared with these before chemotherapy (z = −7.712, z = −2.403, respectively, p &lt; 0.01). Furthermore, the EBPM and TBPM performances of HER2− group survivors were lower than those of HER2+ group survivors after chemotherapy (z = −7.181, p &lt; 0.01; z = −2.205 p &lt; 0.05, respectively). The survivors with COMT (rs165599) A/A genotype carriers had a meaningfully poorer chance of memory descend [dominant model: adjusted, OR = 2.21, CI (95%) = 1.156–4.225, p = 0.016] and showed better on TBPM test, relative to G/G genotype. Patients with the COMT (rs737865) A/G and G/G genotype showed protective function than the patients with the A/A and performed better on MMSE and TBPM tests.ConclusionThe types of HER2 may be correlated to chemotherapy-related prospective memory impairments in breast cancer survivors. Furthermore, the COMT (rs165599, rs737865) polymorphisms were correlated to the risk of TBPM decline scores and possibly be a potential genetic identifying for increasing risk of CRCI in breast cancer patients with disparate status of HER2.
Baseline Amide Proton Transfer Imaging at 3T Fails to Predict Early Response to Induction Chemotherapy in Nasopharyngeal Carcinoma
Authors: Liu Zhou , Zou Liyan , Yang Qian , Qian Long , Li Tianran , Luo Honghong , Che Canwen , Lei Yuanyuan , Chen Peng , Qiu Chunyan , Liu Xin , Wu Yin , Luo Dehong 
Published: February 2022

BackgroundEarly identification of nasopharyngeal carcinoma (NPC) patients with high risk of failure to induction chemotherapy (IC) would facilitate prompt individualized treatment decisions and thus reduce toxicity and improve overall survival rate. This study aims to investigate the value of amide proton transfer (APT) imaging in predicting short-term response of NPC to IC and its potential correlation with well-established prognosis-related clinical characteristics.Methods and MaterialsA total of 80 pathologically confirmed NPC patients receiving pre-treatment APT imaging at 3T were retrospectively enrolled. Using asymmetry analysis, APT maps were calculated with mean (APTmean), 90th percentile (APT90) of APT signals in manually segmented NPC measured. APT values were compared among groups with different histopathological subtypes, clinical stages (namely, T, M, N, and overall stages), EBV-related indices (EBV-DNA), or responses to induction chemotherapy, using Mann–Whitney U test or Kruskal–Wallis H test.ResultsNPC showed significantly higher APTmean than normal nasopharyngeal tissues (1.81 ± 0.62% vs.1.32 ± 0.56%, P &lt;0.001). APT signals showed no significant difference between undifferentiated and differentiated NPC subtypes groups, different EBV-DNA groups, or among T, N, M stages and overall clinical stages of II, III, IVA and IVB (all P &gt;0.05). Similarly, baseline APT-related parameters did not differ significantly among different treatment response groups after IC, no matter if evaluated with RECIST criteria or sum volumetric regression ratio (SVRR) (all P &gt;0.05).ConclusionNPC showed significantly stronger APT effect than normal nasopharyngeal tissue, facilitating NPC lesion detection and early identification. However, stationary baseline APT values exhibited no significant correlation with histologic subtypes, clinical stages and EBV-related indices, and showed limited value to predict short-term treatment response to IC.
Severe Retinopathy of Prematurity Associated With Neurodevelopmental Disorder in Children
Authors: Choi Young-Jin , Hong Eun Hee , Shin Yong Un , Bae Gi Hwan , Kim Inah , Cho Heeyoon 
Published: February 2022

ObjectiveThis study aimed to investigate whether severe retinopathy of prematurity (ROP) could be an association factor for neurodevelopmental disorders in premature infants without other risk factors—such as congenital anomalies, birth injuries, and neurological diseases—that may cause developmental delay.MethodsWe used health claims data recorded between 2007 and 2018 in the Korean National Health Insurance Service (KNHIS) database. We recruited a total of 18,256 premature infant born between 2007 and 2008 without congenital anomaly or birth injury (with ROP 6,995, without ROP 11,261) and divided them into four groups as follows: Group A, 209 extremely premature infants [gestational age (GA) &lt; 28] with mild ROP; Group B, 75 extremely premature infants (GA &lt; 28) with severe ROP; Group C, 6,510 other premature infants (28 ≤ GA &lt;37)with mild ROP; and Group D, 201 other premature infants (28 ≤ GA &lt; 37) with severe ROP. Using regression analysis, we analyzed whether there was a correlation between ROP prevalence, severity, and developmental delay in premature infants without other risk factors.ResultsThe prevalence of developmental delay, according to GA and ROP severity, was higher in patients with severe ROP than in the other patients. The prevalence gradually decreased after birth. Among extremely premature infants with ROP, those with severe ROP had a 3.082-fold higher association with neurodevelopmental complications than those with mild ROP (p &lt; 0.001). Compared with other premature infants with ROP, those with severe ROP had a 3.269-fold higher association with neurodevelopmental complications than those with mild ROP.ConclusionThe severity of ROP may be associated with neurodevelopmental disorders in premature infants.
Research Progress on the Antiemetic Effect of Traditional Chinese Medicine Against Chemotherapy-Induced Nausea and Vomiting: A Review
Authors: Zhao Yao-Zhong , Dai Yong-Zhao , Nie Ke 
Published: February 2022

Chemotherapy-induced nausea and vomiting (CINV), a common side effect in antineoplastic treatment, dramatically decreases the quality of life as well as the compliance of cancer patients. Although numerous antiemetic agents have been used for CINV treatment, its adverse reactions as well as its inadequate control toward delayed emesis still limit its clinical usage. Traditional Chinese medicine (TCM), with more than 3,000 years of practical history in Asia, has been successfully applied to mitigate chemotherapy-induced side effects. Growing attention is drawn to the antiemetic effect of TCM against CINV due to its promising therapeutic property and higher safety recently. In this review, we summarize the classic antiemetic TCM-based treatment and its mechanisms, so as to provide a theoretical basis for further investigations of TCM against CINV in the future.
Impact of Pharmacist-Led Diabetes Self-Care Education on Patients With Type 2 Diabetes in Pakistan: A Randomized Controlled Trial
Authors: Bukhsh Allah , Khan Tahir Mehmood , Phisalprapa Pochamana , Duangjai Acharaporn , Saokaew Surasak , Nawaz Muhammad Sarfraz , Ahmed Hafiz Sajjad , Goh Bey-Hing 
Published: February 2022

Introduction: There is a little evidence on efficacy of pharmacy-based interventions on clinical outcomes of type 2 diabetes mellitus (T2DM) patients in Pakistan.Objective: To appraise the impact of pharmacist-led self-care education on glycemic control, self-care practices and disease knowledge of T2DM patients with poor glycemic control (HbA1c ≥ 7%).Methods: In this 6-months, randomized controlled trial (RCT), n = 75, T2DM patients seeking care at a diabetes clinic were randomized in to two groups. Intervention group (n = 38) received two face-to-face educational sessions (at enrollment and on week 12), whereas control group (n = 37) received usual care. Outcome measures such as glycemic control, self-care practices and disease knowledge were assessed at the time of enrollment and after 6-months in both groups.Results: Thirty-three intervention and thirty-three participants from the control group completed the study. Mean glycated hemoglobin (% HbA1c) significantly reduced in the intervention group from 9.00 ± 1.43 to 8.09 ± 1.16 (p &lt; .01). However, no significant change was observed in the control group (9.20 ± 1.24 to 8.93 ± .97; p = .06). Cohen’s d effect size of the intervention on HbA1c was .78. Percentage of participants achieving glycemic control (HbA1c &lt; 7%) were significantly higher (p &lt; .05) in the intervention group as compared to the control group (twenty-four vs. six), after 6 months of the trial. A significant (p &lt; .01) improvement in mean scores for disease knowledge and self-care activities was also observed in the intervention group participants, whereas no significant improvements (p &gt; .05) were observed in the control group.Conclusion: The study demonstrated an improvement in glycemic control, disease knowledge and self-care activities of T2DM patients who received pharmacist-led educational intervention. The study findings support clinical significance of integrating pharmacy-based interventions in diabetes management.
Effect of Ibandronate Therapy on Serum Chemerin, Vaspin, Omentin-1 and Osteoprotegerin (OPG) in Postmenopausal Osteoporotic Females
Authors: Tariq Saba , Tariq Sundus , Abualhamael Shahad Abduljalil , Shahzad Muhammad 
Published: February 2022

Osteoporosis is a condition in which bone mineral density is reduced due to altered bone microstructure, which results in increased skeletal fragility and incidence of various types of fractures. Adipokines such as chemerin, vaspin, omentin-1 and osteoprotegerin are involved in bone remodeling. The current study was designed to determine the changes in circulating chemerin, vaspin, omentin-1, and osteoprotegerin levels after treatment with oral ibandronate 150 mg in postmenopausal osteoporotic females. The present study enrolled 107 postmenopausal osteoporotic females from a tertiary care hospital in Faisalabad, Pakistan, based on stringent inclusion and exclusion criteria. Sixty-six healthy postmenopausal, non-osteoporotic females with no systemic illness were chosen from the general population. The assessment of bone mineral density (BMD) was done using a DEXA scan. Serum levels of chemerin, vaspin, omentin-1 and osteoprotegerin were estimated using commercially available enzyme-linked immunosorbent assay kits. The collected data were analyzed with the Statistical Package for Social Sciences (SPSS) version 24. Following 6 months of ibandronate treatment, there was a significant decrease of 24.24% (p &lt; .033) in serum chemerin levels, as well as a significant increase in serum vaspin levels 343.32% (p &lt; .001) and osteoprotegerin levels 19.57% (p &lt; .001), with no significant change in omentin-1 levels. Thus, an increase in serum chemerin levels and a decrease in serum vaspin and osteoprotegerin levels could be implicated in osteoporosis.
Association Between Hormonal Birth Control, Substance Use, and Depression
Authors: Newman Sharlene D. 
Published: February 2022

ObjectiveThe current study examined the impact of the use of hormonal birth control, cannabis (CB), and alcohol on depression symptoms.Study DesignSurvey data from 3,320 college-aged women collected over a 2-year period. Depression symptoms were assessed using the PHQ-9.ResultsIndividuals taking hormonal birth control (N = 998; age = 19.1 ± 1.6 years) had lower overall depression scores than did those not taking birth control (N = 2,322; age = 19.1 ± 1.8 years) with 15.2% of those not taking hormonal birth control had depressive symptoms while 12.1% of those in the birth control group had depressive symptoms. Additionally, those taking hormonal birth control had higher scores on the alcohol and CB use assessment. A between-subjects ANOVA with depression score as the dependent variable found significant effects hormonal birth control use, CB and alcohol use, as well as a significant interaction between CB use and hormonal birth control use.ConclusionsWhile there are some limitations (e.g., the between subjects design makes it such that there may be uncontrolled differences between groups), the results suggest that hormonal birth control use may help to reduce depressive symptoms.ImplicationsMore studies examining the impact of hormonal birth control and substance use on depression are required. The results suggest a potential interaction between CB and hormonal birth control use on depression symptoms that is not observed for alcohol. This implies that alcohol and CB may be linked to depression via different mechanisms.
The Effect of Total Cholesterol Variability on Clinical Outcomes After Percutaneous Coronary Intervention
Authors: Liang Yanting , Wang Haochen , Liu Fengyao , Yu Xueju , Liang Yan , Yin Han , Liu Yuting , Jiang Cheng , Wang Yu , Bai Bingqing , Liu Anbang , Shi Xiaohe , Li Weiya , Liu Quanjun , Chen Yilin , Guo Lan , Ma Huan , Geng Qingshan 
Published: February 2022

AimExploring the risk factors of prognosis in patients undergoing percutaneous coronary intervention (PCI) is of great importance. Our aim of the study is to investigate the association between variability in total cholesterol (TC) level and major adverse cardiovascular and cerebrovascular events (MACCE) in patients after PCI.MethodsBetween April 2004 and December 2009, 909 patients who underwent primary PCI and with at least three TC values were included in the final study. TC variability was calculated using four indices: standard deviation (SD), coefficient of variation (CV), the average successive variability (ASV), variability independent of the mean (VIM). MACCE comprised all-cause mortality, non-fatal myocardial infarction (MI), unplanned revascularization, hospitalization for heart failure, and non-fatal stroke.ResultsThere were 394 cases of MACCE during the follow-up period. When the subjects were divided into quartile groups by CV of TC, high CV groups were associated with a higher hazard ratio of MACCE than for lower CV groups. In multivariable adjusted models, TC variability and MACCE remained correlated [HR (95% CI): Q2, 1.17 (0.86–1.58); Q3, 1.38 (1.03–1.85); Q4, 1.63 (1.22–2.17)]. Similar patterns of MACCE were noted by quartiles of SD, ASV, and VIM.ConclusionVisit-to-visit TC variability is positively correlated with MACCE in patients after PCI.
Comparison of Race Time-Differences Between and Within Para and Able-Bodied Cross-Country Skiers
Authors: Carlsen Camilla H. , Severin Cecilia , Sandbakk Øyvind , Baumgart Julia K. 
Published: February 2022

PurposeTo compare differences in race time (i.e., the average percent difference in race time for each skier compared to the winner, RTdiffs) between female and male Para and able-bodied (AB) skiers, and to examine whether RTdiffs change across seasons.MethodsRace data from World Cups (WCs), World Championships (WCHs), and Paralympic/Olympic Winter Games (PWG/OWGs) of the 2011–2020 seasons was extracted from the website of the International Paralympic Committee and the International Ski Federation. All individual distance races for female and male visually impaired standing (VI), physically impaired sitting (SIT) and standing (STAND), and AB skiers with ≥10 competitors were included in the analyses. We investigated the main effect of skiing groups (i.e., VI, STAND, SIT, and AB skiers) and sex on RTdiffs for top-3 and top-8 skiers. Furthermore, the main effect of season and skiing group on RTdiffs for top-3 and top-8 skiers were investigated. All models were adjusted for distance, skiing style (classical- and freestyle), and event type (WC, WCH, and PWG/OWG).ResultsRTdiffs were significantly larger in Para compared to AB skiers (top-3: 2.1 vs. 0.9%; top-8: 6.2 vs. 2.1%, all p &lt; 0.01), and in female compared to male skiers (top-3: 1.8 vs. 1.3%; top-8: 4.9 vs. 3.5%, all p &lt; 0.05). For top-3 skiers, RTdiffs did not significantly differ between the Para categories (all p &gt; 0.2), while for top-8 skiers RTdiffs were significantly larger for VI compared to SIT and STAND (7.0 vs. 5.5 and 5.6%, respectively, all p &lt; 0.05). RTdiffs were stable across the 2011–2020 seasons for top-3 skiers (VI: 1.7–3.6%, STAND: 1.1–2.2%, SIT: 1.0–3.9%, AB: 0.4–1.1%; all p &gt; 0.1) and top-8 skiers (VI: 3.4–12.0%, STAND: 2.6–5.7%, SIT: 1.9–5.9%, AB: 0.1–1.7%; all p &gt; 0.1).ConclusionThe larger RTdiffs in Para compared to AB skiers indicate larger variability in performance, which are in part disability related. Female skiers displayed larger RTdiffs than their male counterparts, indicating larger variability in performance among the female skiers. Our results provide insights about performance demands in Para cross-country skiing, which is of relevance for coaches and skiers.
Amputation Predisposes to Higher Cancer-Specific Mortality Than Limb Salvage Surgery in Pediatric Patients With Osteosarcoma of the Limbs: A Propensity Matching Analysis
Authors: Wang Jinkui , Tang Jie , Tan Xiaojun , Zhanghuang Chenghao , Jin Liming , Li Mujie , Zhang Zhaoxia , Mi Tao , He Dawei 
Published: February 2022

ObjectiveWith the development of osteosarcoma treatment, limb salvage surgery is gradually replacing amputation as the primary surgical option. Most pediatric osteosarcomas of the limbs undergo limb-salvage surgery. We aimed to use propensity score matching (PSM) analysis test the difference in cancer-specific mortality (CSM) between amputation and limb-salvage surgery in pediatric patients with Osteosarcoma of the limbs. PSM is a statistical method used to deal with data from an Observational Study. The PSM method is designed to reduce the influence of biases and confounding variables to make a more reasonable comparison between experimental and control groups.MethodsPatient information was downloaded from the SEER (surveillance, epidemiology, and End Results) database from 2004 to 2018. We included all primary pediatric osteosarcoma patients who underwent limb salvage or amputation. Multivariate logistic regression models were used to explore the factors influencing patient choice of amputation. Differences in CSM and other causes of mortality (OSM) between limb salvage and amputation were analyzed using cumulative incidence plots and competitive risk regression tests after 1:1 proportional propensity score matching.ResultsA total of 1,058 pediatric patients with limbs Osteosarcoma were included. Patients who underwent amputations were more likely to be male (OR 1.4, P = 0.024) and more likely to have distant metastasis (OR 2.1, P &lt; 0.001). Before propensity matching, CSM was 1.4 times higher in patients undergoing amputation than in patients undergoing limb salvage (P = 0.017) and 3.4 times higher in OSM (P = 0.007). After adjustment for propensity matching, CSM was 1.5 times higher in patients undergoing amputation than in patients undergoing limb salvage (P = 0.028), but there was no significant difference in OSM (HR 3.2, P = 0.078).ConclusionsOur results suggested that amputation is associated with a 1.5-fold increase in CSM in pediatric patients with limbs Osteosarcoma. Therefore, in the surgical selection of pediatric patients with Osteosarcoma, limb salvage surgery should be the first choice in the absence of other contraindications.
Features of the Clinical Course of Fungal Maxillary Sinusitis
Authors: Кока К.Е. , Меркулова Е.П. , Саврасова Н.А. , Кобахидзе А.Г. , Колесникова С.Н. 
Published: February 2022

Введение. Статья посвящена анализу особенностей клинических и рентгенологических проявлений грибкового поражения верхнечелюстных пазух по данным историй болезни 27 пациентов оториноларингологического отделения УЗ «11-я ГКБ» с различными формами грибкового риносинусита. Цель. Повышение эффективности диагностики и лечения пациентов с грибковым риносинуситом на основании анализа особенностей клинических, рентгенологических и лабораторных данных. Материалы и методы. Проанализированы результаты диагностических мероприятий 27 пациентов с различными формами грибкового риносинусита. Результаты. Установлены малосимптомность заболевания, агрессивное поражение слизистой оболочки пазухи, вовлечение других околоносовых пазух, закрытый остеомеатальный комплекс, разрушение латеральной стенки полости носа. Выводы. Пациенты с подозрением на грибковое поражение верхнечелюстной пазухи требуют междисциплинарного подхода с анализом рентгенологических исследований, осмотром челюстно-лицевого хирурга и врача-стоматолога для определения последовательности и объемов хирургического лечения.
Introduction. The article is devoted to the analysis of the features of clinical and radiological manifestations of fungal infections of the maxillary sinuses. Purpose. Improving the efficiency of diagnostics and treatment of patients with fungal rhinosinusitis based on the analysis of clinical, radiological and laboratory data. Materials and methods. There were analyzed the results of diagnostic procedures in 27 patients with various forms of fungal rhinosinusitis. Results. The following was found: low-symptom disease, aggressive damage to the sinus mucosa, involvement of other paranasal sinuses, closed osteomeatal complex, destruction of the lateral wall of the nasal cavity. Conclusions. Patients with suspected fungal infection of the maxillary sinus require interdisciplinary approach with the analysis of X-ray examinations, examination of the maxillofacial surgeon and dentist to determine the sequence and scope of surgical treatment.
Modern Antidepressants in the Treatment of Mental Disorders in Post-COVID Conditions
Authors: Кирпиченко А.А. 
Published: February 2022

В статье приведены данные о психических нарушениях при коронавирусной инфекции и постковидном синдроме (U09.9). Сделан литературный обзор эффективности антидепрессантов различных групп в лечении коронавирусной инфекции. Описаны особенности мультимодального антидепрессанта вортиоксетин как в рамках коронавирусной инфекции, так и при изолированных расстройствах депрессивного спектра. Сделаны выводы о потенциале антидепрессантов в терапии депрессий при инфекции COVID-19.
The article provides data on mental disorders in coronavirus infection and COVID syndrome (U09.9). A literature review about the effectiveness of antidepressants of various groups in the treatment of coronavirus infection was made. The features of the multimodal antidepressant vortioxetine are described both within the framework of coronavirus infection and in isolated disorders of the depressive spectrum. The conclusions are drawn about the potential of antidepressants in the treatment of depression in COVID-19 infection.