bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic and Predictive Value of Liquid Biopsy-Derived Androgen Receptor Variant 7 (AR-V7) in Prostate Cancer: A Systematic Review and Meta-Analysis
Authors: Khan Tanzila , Becker Therese M. , Scott Kieran F. , Descallar Joseph , de Souza Paul , Chua Wei , Ma Yafeng 
Published: March 2022

In advanced prostate cancer, access to recent diagnostic tissue samples is restricted and this affects the analysis of the association of evolving biomarkers such as AR-V7 with metastatic castrate resistance. Liquid biopsies are emerging as alternative analytes. To clarify clinical value of AR-V7 detection from liquid biopsies, here we performed a meta-analysis on the prognostic and predictive value of androgen receptor variant 7 (AR-V7) detected from liquid biopsy for patients with prostate cancer (PC), three databases, the Embase, Medline, and Scopus were searched up to September 2021. A total of 37 studies were included. The effects of liquid biopsy AR-V7 status on overall survival (OS), radiographic progression-free survival (PFS), and prostate-specific antigen (PSA)-PFS were calculated with RevMan 5.3 software. AR-V7 positivity detected in liquid biopsy significantly associates with worse OS, PFS, and PSA-PFS (P &lt;0.00001). A subgroup analysis of patients treated with androgen receptor signaling inhibitors (ARSi such as abiraterone and enzalutamide) showed a significant association of AR-V7 positivity with poorer OS, PFS, and PSA-PFS. A statistically significant association with OS was also found in taxane-treated patients (P = 0.04), but not for PFS (P = 0.21) or PSA-PFS (P = 0.93). For AR-V7 positive patients, taxane treatment has better OS outcomes than ARSi (P = 0.01). Study quality, publication bias and sensitivity analysis were integrated in the assessment. Our data show that liquid biopsy AR-V7 is a clinically useful biomarker that is associated with poor outcomes of ARSi-treated castrate resistant PC (CRPC) patients and thus has the potential to guide patient management and also to stratify patients for clinical trials. More studies on chemotherapy-treated patients are warranted.Systematic Review RegistrationPROSPERO, CRD42021239353.
Medication Use and Costs Among Older Adults Aged 90 Years and Older in Italy
Authors: Zazzara Maria Beatrice , Cangini Agnese , Da Cas Roberto , Ippoliti Ilaria , Marengoni Alessandra , Pierantozzi Andrea , Poluzzi Elisabetta , Zito Simona , Onder Graziano , the Italian Working Group on Medication Use in the Elderly  
Published: March 2022

Older adults are often affected by multiple chronic conditions and experience geriatric syndromes that may affect the risk/benefit profile of medications. Little is known about the use of such medications in the older population. This article describes medication use and costs in Italian adults aged ≥90 years. Data from the 2019 Pharmaceutical Prescriptions database, concerning data on medications reimbursed by the Italian National Health Service, were analyzed in terms of prevalence and amount of use expressed as defined daily dose/1,000 users (DDD/1,000 users/day), accounting for different age-groups and sex. All individuals aged ≥90 years used at least one medication, with a mean number of 3128 DDD/1,000 users/day corresponding to an annual cost of 683 euros per user. Both use and costs linearly decreased with increasing age, with men accounting for a higher amount of DDD/1,000 users and costs than women across all age-groups. Antihypertensives (1330 DDD/1,000 inhabitants), antiplatelet agents (337 DDD/1,000 inhabitants), medications for peptic ulcer and gastroesophageal reflux (328 DDD/1,000 inhabitants), and lipid-lowering agents (166 DDD/1,000 inhabitants) were the most frequently used medications. We observed a progressive decrease in the usage of the majority of medications with increasing age, with the exception of antibiotics and antipsychotics. Individuals aged ≥90 years used a lower DDD/1,000 users, with an associated decrease in annual costs. The persistent use of preventive medications highlights the potential lack of awareness regarding medication rationalization and guidance for optimizing prescriptions. Our findings highlight the need for further initiatives to improve medications’ appropriateness in these older age-groups.
PENGARUH DOSIS LIMBAH KULIT PISANG (Musa paradisiaca) TERHADAP BERAT PADA CACING TANAH (Lumbricus terrestris) SEBAGAI PANDUAN PRAKTIKUM PADA PEMBELAJARAN BIOLOGI
Authors: Selpianara Amelia , Lestari Mega Ayu , Sari Mirna Novita , Martjianto Fadli 
Published: March 2022

Penelitian ini bertujuan untuk mengetahui pengaruh dosis limbah kulit pisang terhadap berat cacing tanah. Cacing tanah merupakan hewan yang cukup potensial sebagai hewan budidaya, dan cacing tanah ini sangat cepat untuk berkembang biak. Cacing yang digunakan sebanyak 90 ekor cacing, tiap wadah diisi dengan 3 ekor cacing, dengan menggunakan 5 perlakukan dan 5 kali pengulangan. Dosis limbah kulit pisang yang digunakan berbeda-beda yaitu 60gr, 70gr ,80gr ,90gr, dan 100gr, dalam penelitian ini hal yang paling utama diukur adalah berat awal cacing dan berat akhir cacing. Penelitian menggunakan pendekatan penelitian dan pengembangan. Hasil penelitian dikembangkan menjadi panduan praktikum. Model pengembangan menggunakan model 4-D dan hanya sampai tahap pengembangan pada validasi ahli. Terkait pengaruh pemberian limbah kulit pisang didapatkan hasil pada uji anava 1 jalan nilai signifikansi 0,000 0,05 yang berarti terdapat perbedaan rata-rata pada tiap perlakuan dosis limbah kulit pisang. Pada uji lanjut menggunakan Duncan didapatkan hasil semua perlakuan memiliki perbedaan secara nyata, dimana perlakuan 100 gr mendapat rata-rata nilai tertinggi. Hasil pengembangan panduan praktikum berdasarkan validasi dari ahli materi mendapatkan nilai sebesar 87,6 dengan kriteria valid. Hasil penilaian dari ahli media mendapakan nilai persentase sebesar 91,7% dengan kriteria valid.Keywords: Kulit Pisang, Cacing Tanah, Panduan Praktikum
UJI ORGANOLEPTIK KERUPUK BERBAHAN DASAR BAWANG DAYAK (Eleutherine bullbosa) SERTA KAJIANNYA DALAM PENINGKATAN NILAI TAMBAH BAHAN PANGAN LOKAL KOTA TARAKAN DAN SUMBER BELAJAR BIOLOGI
Authors: Setyawan Fajar , Hazliza Hazliza , Dewi Septiana Sari , Qohar Zaenuri Abdul 
Published: March 2022

Pengembangan produk lokal berbahan dasar bawang dayak masih sangat jarang. Berdasarkan hal ini, maka dilakukan pengolahan bawang dayak dalam bentuk krupuk. Penelitian ini menggunakan pendekatan mixed method (kuantitatif dan kualitatif). Pendekatan kuanitatif menggunakan uji organoleptik pada berbagai perlakuan dosis bawang dayak. Sementara, pendekatan kualitatif melalui analisis kesuaian hasil penelitian dengan pembelajaran biologi. Hasil penelitian berdasarkan uji organoleptik pada responden tidak terlatih dan semi terlatih didapatkan hasil bahwa dosis bawang dayak sebesar 2 sdt merupakan dosis paling optimal dalam campuran kerupuk. Hasil penelitian dapat dijadikan konten atau contoh projek dalam matakuliah gastronomi, terkait dengan materi pengolahan makan berbasis potensi lokal. Kata Kunci: Uji Organoleptik, Bawang Dayak, Biologi
INVENTARISASI SPESIES PADA SUKU POACEAE DI TARAKAN SEBAGAI PANDUAN IDENTIFIKASI
Authors: Hayutiasti Galuh Utari , Fitriani Riska Audina , Ningsih Nurul Setia 
Published: March 2022

Tujuan dalam penelitian ini adalah untuk mengetahuai jenis-jenis Suku Poaceae di Hutan Penelitian Universitas Borneo Tarakan dan untuk mengembangkan hasil penelitan menjadi buku panduan identifikasi. Penelitian menggunakan model pengembangan Borg and Gall yang diadaptasi sampai pada tahap ke tiga. Hasil penelitian Suku Poaceae telah ditemukan sebanyak 12 Marga yang terdiri dari 15 jenis. Jenis terbanyak pada marga Erangrotis sebanyak 3 jenis, dan Panicum sebanyak 2 jenis. Sementara, untuk marga yang lainnya hanya ditemukan 1 jenis saja. Hasil penelitian kemudian dikembangkan menjadi buku panduan identifikasi. Hasil validasi ahli materi dan ahli media mendapatkan persentase masing-masing sebesar 86,3% dan 92,9% dengan kriteria valid. Kata Kunci: Poaceae, Panduan Identifikasi
PENERAPAN LESSON STUDY UNTUK MENINGKATKAN KEMAMPUAN PENGELOLAAN KELAS DAN HASIL BELAJAR KOGNITIF DIKELAS VIII-J SMPN 2 TARAKAN PADA MATERI STRUKTUR DAN FUNGSI JARINGAN TUMBUHAN SERTA PEMANFAATANYA DALAM TEKNOLOGI
Authors: Silaban Lisdawati , Hayati Rita 
Published: March 2022

Abstract: The implementation of the 2013 Curriculum at SMP Negeri 2 Tarakan requires teaching staff to always be active and creative in class processing with the aim that students' cognitive learning outcomes increase in accordance with predetermined minimum grade completeness standards. Based on this, the existence of teachers to manage an optimal and conducive classroom is needed. One of the efforts made by the teacher in improving the ability to manage the class and students' cognitive knowledge is by implementing lesson study activities. The type of research used is lesson study-based action research using a qualitative descriptive approach. The class used as research was VIII-J which was observed by 3-5 observers using 4 cycles. Based on the data analysis and discussion that has been done, the results obtained are: 1) the implementation of lesson study from the plan, do, and see stages has increased from lesson study I to IV with an average of 93% in the very accomplished category; 2) The ability to manage the classroom by the model teacher through the implementation of lesson study obtained an average score of 76.5% in the good category; 3) The development of the ability to manage the classroom by the model teacher through the implementation of lesson study in relation to student learning outcomes has increased. Keywords: lesson study, manage the class, cognitive knowledge
PENGEMBANGAN MEDIA PEMBELAJARAN MONOPOLI BERBASIS GAME HAGO PADA MATERI VIRUS KELAS X SMA
Authors: Anggraini Bella , Vlorensius Vlorensius , Zulfadli Zulfadli 
Published: March 2022

The purpose of this study is to analys the quality of monopoly based on Game Hago. The Hago Game-based monopoly on virus material for class X SMA is very feasible as a learning medium with the percentage of material experts being 84% (very feasible), media experts being 96% (very feasible). Game-based monopoly Hago gets a response from expert practitioners who are teachers of Biology subjects at the Hang Tuah Tarakan High School of 94% (very feasible) and student responses using Hago Game-based Monopoly learning media are 92% (very good). Keywords: Monopoly based on Hago Game, Quality
EKSPLORASI TUMBUHAN OBAT DI HUTAN PENELITIAN UNIVERSITAS BORNEO TARAKAN SEBAGAI BAHAN AJAR BERUPA BOOKLET UNTUK SISWA KELAS X SMK KESEHATAN KALTARA TARAKAN
Authors: Alfrida Alfrida , Rupa Darius , Nugroho Endik Deni 
Published: March 2022

This study aimed to determine the types of medicinal plants in the forest area of the Borneo Tarakan University and produce a product in the form booklet that are suitable for use. The type of this research was Research and Development (R D) which uses the development model of Borg and Gall (1983) and is only carried out up to the fifth stage. The results showed that 15 species were found, Kayu putih (Melaleuca leucadendron L.), Paku picisan (Drymoglossum pilloselloides L.), Karamunting (Melastoma malabathricum L.), Resam (Dicronopteris linearis L.), Pandan (Pandanus Sp.), Paku kawat (Lycopodium cernuum L. ), Congkok (Molineria capitulate L.), Jintan (Plectranthus amboinicus L.), Kantong semar (Nepenthes ampullaria), Anggrek tanah (Bromheadia finlaysoniana L.), Hiring-Hiring (Scleria sumatrensis Retz.), Lengkuas (Alpinia galangal L.), Paku tanduk (Platycerium bifurcatum), Paku sarang burung (Asplenium nidus L.), Paku kasak (Blechnum orientale L.). The result of research development in the form booklet were resulted scores validation from that are 86.6% (very feasible), material experts at 80% (feasible), practitioners at 100% (very feasible) and the percentage of student response tests at 94.5% (very interesting. The concluded of this research is the medicinal booklet with medicinal properties in the Borneo Forest Tarakan Research Forest Area is feasible to be used as teaching material for grade X SMK students.Keywords: Medicinal Plants, Booklet
PENGARUH MODEL STUDENT TEAMS-ACHIEVEMENT DIVISIONS (STAD) BERBANTUAN MEDIA MIND MAPPING TERHADAP KEMAMPUAN BERPIKIR KRITIS SISWA SEKOLAH DASAR
Authors: Ningsih Jumeiti Tiku , Andari Kadek Dewi Wahyuni 
Published: March 2022

This research aims to determine the effect by application Student Teams-Achievement Divisions (STAD) type cooperative learning models assisted by Mind Mapping media on the critical thinking skills of Grade IV SD Citra Tarakan students. This research is a quantitative type of quasi-experimental research. This research was conducted in January-February 2020. With a population of fourth grade students at Citra Bangsa Tarakan Elementary School and the sample consisted of one class, namely class IV A which was given treatment. The technique in taking the sample used is Purposive Sampling. The research data were processed with SPSS V.21 for Windows Software. The results of this study indicate that there is an influence on the application of Student Teams-Achievement Divisions (STAD) type cooperative learning models assisted by Mind Mapping media on students' critical thinking abilities. This study shows that the correlation results obtained that the effect of the learning model is very strong with the results of the correlation coefficient of 0.888 and the coefficient of determination of 0.789 or 78.9% and the submission of the hypothesis obtained tcount of 8.638 at a significant level α = 0.05 with df = 20 obtained table of 2,085 means tcount ttable. Keywords: Cooperative learning model type Student Teams-Achievement Divisions (STAD), Critical Thinking Ability,Media Mind Mapping
PENGARUH PEMBELAJARAN DARING MENGGUNAKAN WHATSAPP GRUP TERHADAP HASIL BELAJAR MAHASISWA PENDIDIKAN BIOLOGI IAIN KENDARI DITINJAU DARI KESADARAN METAKOGNITIF
Authors: Syam Andi Nurannisa , Rizalia Syarif 
Published: March 2022

This study aims to determine the effect of online learning through WhatsApp on student’s learning outcome of biology education IAIN Kendari considering metacognitive awareness. This study is a quantitative type of quasi-experimental research with a 1x3 experimental design. This research was conducted in October 2020, with a population of fifth-semester students of biology education, and the sample consisted of one class, namely class B, which was given treatment. The data were analyzed using SPSS for Windows Software. The technique in taking the sample was Cluster Random Sampling. The results revealed a positive influence on the application of online learning through WhatsApp on student’s learning outcome consideration of metacognitive awareness. The finding also proves that high metacognitive awareness students have better learning outcomes than students with middle and low metacognitive awareness. Keywords: online learning, WhatsApp, learning outcome. metacognitive awareness.
HUBUNGAN PRAKTIKUM TERHADAP HASIL BELAJAR PESERTA DIDIK PADA PRA PANDEMI DAN SELAMA PANDEMI COVID-19: POTENSI LEARNING LOSS
Authors: Fatmawati Fatmawati 
Published: March 2022

Abstract: This study aimed to analyze the relationship between practicum and student learning outcomes in the pre-pandemic and during the Covid-19 pandemic. The research method applied is descriptive quantitative research which is supported by data collection techniques in the form of interviews, observations, and documentation. The research subjects are students of Biology Education, University of Borneo Tarakan. The results of data analysis showed that most of the practicums were carried out in the pre-covid-19 pandemic but only a few practicums were carried out during the pandemic with different practicum forms. This indicates the occurrence of learning loss in learning that practices science. Practicum is closely related to student learning outcomes. The relationship tends to be linear where student learning outcomes can increase in line with the quantity and quality of the practicum. Keywords: Learning Outcomes, Learning Loss, Practicum
ANALISIS KEMAMPUAN LITERASI SAINS SISWA SMP KELAS VIII DI KOTA TARAKAN
Authors: Alisha Irma , Listiani Listiani , Vlorensius Vlorensius 
Published: March 2022

Abstract: This research is motivated by the low achievement of scientific literacy in Indonesia in the Program for International Student Assessment (PISA) study participation held every three years by the Organization for Economic Co-operation and Development (OECD). This study aims to determine the scientific literacy ability of Class VIII Junior High School students in Tarakan City, which was taken using the Purposive Sampling technique. The data was taken using a test method in the form of a description question. The test given was adopted from the PISA questions published by the National Assessment Program (NAP) published in 2009 and translated into Indonesian. The results showed that the Science Literacy Ability of Class VIII Junior High School Students in Tarakan City was categorized as less with a percentage of 44.04%. At each level, students can only answer questions with levels 1 and 2, while for questions with levels 3 and 4, they are still very lacking. So it was concluded that the scientific literacy skills of class VIII junior high school students in Tarakan City were still lacking. Keywords: scientific literacy, student, PISA
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS PERMAINAN CONGKLAK PADA MATERI ZAT ADITIF & ZAT ADIKTIF KELAS VIII DI SMP ISLAM TERPADU (IT) IBNU ABBAS TARAKAN
Authors: Ningsih Rika Yulianti , Wijarini Fitri , Fatmawati Fatmawati 
Published: March 2022

Abstract: The purpose of the research was to analyze the feasibility of congklak learning media on materials of additives of addictive substances for the eighth-graders at SMP Islam Terpadu (IT) Ibnu Abbas Tarakan based on material expert, media expert, and practitioners. The research design was Research and the Development (RD), which refers to the 4-D (four D) model developed by Thiagarajan et al. 1974. This model includes the stages of defining, designing, developing and disseminating. However, in this research, the researcher developed the learning media to the third stage D, the development stage. It was caused by the limitation of time and budget. The material expert validation analysis result was 80% in a feasible category. The media expert validation analysis result was 82% in a very feasible category. In addition, The result of the practitioners was 86% in a very feasible category. Based on the analysis results, it was concluded that the developed media had met the media eligibility standards. It was used as learning media. Keywords: : Learning Media, Congklak, Additives and Addictive Substances
L’autofiction, médium artistique interdisciplinaire
Authors: Péron-Douté Eugénie 
Published: March 2022

Le lien entre littérature contemporaine et arts contemporains semble particulièrement fécond en étudiant l’autofiction. Tout d’abord genre littéraire, l’autofiction semble avoir dépassé ce seul cadre pour s’épanouir dans une relation symbiotique jumelant les nouvelles formes de littératures et de performances que nous renommons « néo-littérature » et « néo-performance ». L’étude de trois écrivains (Paul Beatriz Preciado, Éric Chevillard et Chloé Delaume) nous permet de mener à bien notre analyse. Cette pluralité (a contrario d’un cas isolé) nous permet de montrer la systématisation de ce lien s’épanouissant au sein de l’autofiction devenue un médium artistique interdisciplinaire.
The Black Veil de Rick Moody, roman ventriloque
Authors: Chapuis Sophie 
Published: March 2022

The Black Veil est un texte dont l’ambiguïté générique nous invite à repenser le paradigme autobiographique car en lieu et place d’un récit de soi, Rick Moody livre une autofiction reposant sur une imposture qui n’est révélée au lecteur qu’au terme du roman. La parenté entre la famille Moody et le révérend Joseph Moody, pasteur puritain qui aurait inspiré à Nathaniel Hawthorne son personnage du pasteur au voile noir, s’avère totalement infondée. Cet article envisage la mise en échec systématique de l’élan autobiographique comme principe central présidant à l’écriture d’un texte qui privilégie la dissimulation à la confession. Parcouru par de multiples voix, ce récit est celui d’un « je » associatif, qui se déploie en réseau et substitue à la quête identitaire individuelle une quête d’identité nationale. Ne se dévoilant qu’à mots couverts, Moody s’inclut dans une première personne plurielle et redéfinit le récit de soi comme étant nécessairement le récit d’une communauté.
Kanker Paru: Laporan Kasus
Authors: Joseph Junita , Rotty Linda W. A. 
Published: March 2022

Abstract: In general, lung cancer is all kinds of malignancy of the lung. It consists of malignancy derived from the lung itself (primary) and from out of the lung (metastasis). Clinically, primary lung cancers are malignant tumors derived from bronchial epithelium (bronchial carcinoma). Lung cancer is the main cause of death due to malignancy worldwide. We reported a male of 55-year-old male diagnosed as lung cancer. Diagnosis was based on anamnesis, physical examination, and supporting investigations. Anamnesis included smoking for 10 years ±15 cigarettes/day and complaints of shortness of breath, coughing, chest pain radiating to the back, and significant weight loss. Physical examination revealed enlargement of the right supraclavicular gland and decreased breath sounds in the right lung at the fifth intercostal space. Thorax photo, thorax CT-scan, and histopathological examination confirmed the diagnosis of lung cancer (adeno-carcinoma). Chemotherapy was administered with a combination of gemcitabine-cisplatin regimens for 12 cycles. The prognosis of this patient was poor because the disease had reached stage 4. However, the patient felt some clinical improvement after one month of chemotherapy.Keywords: lung cancer Abstrak: Kanker paru dalam arti luas adalah semua penyakit keganasan di paru, mencakup keganasan yang berasal dari paru sendiri (primer) maupun keganasan dari luar paru (metastasis). Dalam pengertian klinis yang dimaksud dengan kanker paru primer adalah tumor ganas yang berasal dari epitel bronkus (karsinoma bronkus). Kanker paru merupakan penyebab utama kematian akibat keganasan di dunia Kami melaporkan sebuah kasus kanker paru pada seorang laki-laki berusia 55 tahun. Diagnosis ditegakkan berdasarkan anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang yang meliputi adanya riwayat merokok (sigaret) selama 10 tahun sebanyak ±15 batang rokok/hari, dengan sesak nafas, batuk, nyeri dada menjalar sampai ke punggung, dan penurunan berat badan yang nyata. Pada pemeriksaan fisik didapatkan pembesaran kelenjar supraklavikular kanan dan suara nafas menurun pada paru kanan setinggi sela iga V. Pada pemeriksaan penunjang foto toraks, thorax CT-scan, dan histopatologik didapatkan hasil yang menyokong diagnosis kanker paru (adenokarsinoma). Pada pasien ini, telah diberikan penata-laksanaan kemoterapi dengan kombinasi regimen gemcitabine-cisplatin selama 12 siklus. Progno-sis pasien ini buruk karena sudah sampai pada stadium 4, namun dengan kemoterapi yang dijalani sampai saat ini selama 1 bulan, pasien merasakan adanya perbaikan secara klinis.Kata kunci: kanker paru