bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autistic Parents’ Personal Experiences of Parenting and Support: Messages from an Online Focus Group
Authors: Hwang Se Kwang , Heslop Philip 
Published: July 2022

Abstract
Social work with autistic adults should be operated within principles of personalisation and strength-based approach. Whilst many parents are diagnosed on the autistic spectrum as adults, their needs, different parenting styles and capabilities have been often misunderstood, or seldom respected by professionals. To address this gap, this study explored autistic parents’ experiences of parenting and support. In order to examine ‘real-life’ through the parent’s own points of view, an online focus group was used to explore seven autistic parents’ own perspectives and experiences. Data were analysed via thematic techniques. This study found that the parents claimed that autism may not impact always on their parenting capacity, and, when it does, they can succeed in raising their children, especially their autistic children, if they are provided with appropriate support services. But their parenting style and capabilities were misunderstood by professionals who used traditional pathologising assumptions on parental capacity. This study concluded that dismantling stereotypical norms of autism and lack of knowledge of autism within professionals is needed to change to properly assess autistic parent’s needs and their capacity using strength-based approach.
A novel framework to estimate cognitive impairment via finger interaction with digital devices
Authors: Holmes Ashley A , Tripathi Shikha , Katz Emily , Mondesire-Crump Ijah , Mahajan Rahul , Ritter Aaron , Arroyo-Gallego Teresa , Giancardo Luca 
Published: July 2022

Abstract
Measuring cognitive function is essential for characterizing brain health and tracking cognitive decline in Alzheimer’s Disease and other neurodegenerative conditions. Current tools to accurately evaluate cognitive impairment typically rely on a battery of questionnaires administered during clinical visits which is essential for the acquisition of repeated measurements in longitudinal studies. Previous studies have shown that the remote data collection of passively monitored daily interaction with personal digital devices can measure motor signs in the early stages of synucleinopathies, as well as facilitate longitudinal patient assessment in the real-world scenario with high patient compliance. This was achieved by the automatic discovery of patterns in the time series of keystroke dynamics, i.e. the time required to press and release keys, by machine learning algorithms. In this work, our hypothesis is that the typing patterns generated from user-device interaction may reflect relevant features of the effects of cognitive impairment caused by neurodegeneration. We use machine learning algorithms to estimate cognitive performance through the analysis of keystroke dynamic patterns that were extracted from mechanical and touchscreen keyboard use in a dataset of cognitively normal (n = 39, 51% male) and cognitively impaired subjects (n = 38, 60% male). These algorithms are trained and evaluated using a novel framework that integrates items from multiple neuropsychological and clinical scales into cognitive subdomains to generate a more holistic representation of multifaceted clinical signs. In our results, we see that these models based on typing input achieve moderate correlations with verbal memory, non-verbal memory and executive function subdomains [Spearman’s ρ between 0.54 (P &lt; 0.001) and 0.42 (P &lt; 0.001)] and a weak correlation with language/verbal skills [Spearman’s ρ 0.30 (P &lt; 0.05)]. In addition, we observe a moderate correlation between our typing-based approach and the Total Montreal Cognitive Assessment score [Spearman’s ρ 0.48 (P &lt; 0.001)]. Finally, we show that these machine learning models can perform better by using our subdomain framework that integrates the information from multiple neuropsychological scales as opposed to using the individual items that make up these scales. Our results support our hypothesis that typing patterns are able to reflect the effects of neurodegeneration in mild cognitive impairment and Alzheimer’s disease and that this new subdomain framework both helps the development of machine learning models and improves their interpretability.
A financial straitjacket? Côte d’Ivoire’s National Development Banks
Authors: Quist Georges 
Published: July 2022

AbstractThe lack of financing options for African firms has led to a reappraisal of the role National Development Banks (NDBs) can play in promoting structural transformation the region. Through an analysis of bank data and policy reports, I argue that the focus on corruption by the mainstream to explain the lacklustre performance of NDBs in developing and emerging economies is overemphasised. Specifically, such arguments fail to account for underlying structural and relational asymmetries between financial sector participants, which make it difficult for NDBs to accomplish their mission. In Côte d’Ivoire, these constraints are characterised by a monetary system inherited from the colonial period that prioritises exchange rate stability over credit creation. The increasing push by International Financial Institutions to commercialise state banking is also causing the main Ivorian NDB (the Banque Nationale d’Investissement) to prioritise financial intermediation over the provision of credit to enterprises in productive sectors.
Connecting financialisation and structural change: a critical appraisal regarding Brazil
Authors: Corrêa Mariana Finello , Feijo Carmem 
Published: July 2022

Abstract
The contribution of this paper is to discuss the particularities of financialisation in peripheral economies, emphasising the channels through which financialisation contributes to redefining their trajectory of structural change. This paper has, as a reference, the structural regression of the Brazilian case, which is characterised by the deindustrialisation and trade specialisation marked by export reprimarisation. The aspects covered are the financialisation of non-financial corporations, of the exchange rate and of the determination of the commodity prices, which are associated with the Dutch disease.
From novel discovery tools and biomarkers to precision medicine—basic cardiovascular science highlights of 2021/22
Authors: Evans Paul C , Davidson Sean M , Wojta Johann , Bäck Magnus , Bollini Sveva , Brittan Mairi , Catapano Alberico L , Chaudhry Bill , Cluitmans Matthijs , Gnecchi Massimiliano , Guzik Tomasz J , Hoefer Imo , Madonna Rosalinda , Monteiro João P , Morawietz Henning , Osto Elena , Padró Teresa , Sluimer Judith C , Tocchetti Carlo Gabriele , Van der Heiden Kim , Vilahur Gemma , Waltenberger Johannes , Weber Christian 
Published: July 2022

AbstractHere, we review the highlights of cardiovascular basic science published in 2021 and early 2022 on behalf of the European Society of Cardiology Council for Basic Cardiovascular Science. We begin with non-coding RNAs which have emerged as central regulators cardiovascular biology, and then discuss how technological developments in single-cell ‘omics are providing new insights into cardiovascular development, inflammation, and disease. We also review recent discoveries on the biology of extracellular vesicles in driving either protective or pathogenic responses. The Nobel Prize in Physiology or Medicine 2021 recognized the importance of the molecular basis of mechanosensing and here we review breakthroughs in cardiovascular sensing of mechanical force. We also summarize discoveries in the field of atherosclerosis including the role of clonal haematopoiesis of indeterminate potential, and new mechanisms of crosstalk between hyperglycaemia, lipid mediators, and inflammation. The past 12 months also witnessed major advances in the field of cardiac arrhythmia including new mechanisms of fibrillation. We also focus on inducible pluripotent stem cell technology which has demonstrated disease causality for several genetic polymorphisms in long-QT syndrome and aortic valve disease, paving the way for personalized medicine approaches. Finally, the cardiovascular community has continued to better understand COVID-19 with significant advancement in our knowledge of cardiovascular tropism, molecular markers, the mechanism of vaccine-induced thrombotic complications and new anti-viral therapies that protect the cardiovascular system.
Percutaneous drainage of a localized biatrial haematoma causing regional tamponade in a patient with prior coronary artery bypass graft surgery: a case report
Authors: Achim Alexandru , Toia Damien , Leibundgut Gregor 
Published: July 2022

Abstract

Background
Regional cardiac tamponade presented as posterior extrapericardial haematomas compressing both atria, with cardiogenic obstructive shock due to inflow abolition is a rare cause of post-percutaneous coronary intervention vascular collapse.

Case summary
We present such a case where computed tomography-guided anterior pericardiocentesis decompressed the atria and restored cardiac output.

Discussion
Prior coronary artery bypass grafting should not be considered protective from cardiac tamponade in patients in whom perforation occurs, because loculated effusions can develop beneath adhesions of the pericardium and compress various cardiac structures (such as the left atrium or the right ventricle); they appear several hours after the intervention and cause atypical haemodynamic manifestations.
Patiromer for the management of hyperkalemia in heart failure with reduced ejection fraction: the DIAMOND trial
Authors: Butler Javed , Anker Stefan D , Lund Lars H , Coats Andrew J S , Filippatos Gerasimos , Siddiqi Tariq Jamal , Friede Tim , Fabien Vincent , Kosiborod Mikhail , Metra Marco , Piña Ileana L , Pinto Fausto , Rossignol Patrick , van der Meer Peter , Bahit Cecilia , Belohlavek Jan , Böhm Michael , Brugts Jasper J , Cleland John G F , Ezekowitz Justin , Bayes-Genis Antoni , Gotsman Israel , Goudev Assen , Khintibidze Irakli , Lindenfeld Joann , Mentz Robert J , Merkely Bela , Montes Eliodoro Castro , Mullens Wilfried , Nicolau Jose C , Parkhomenko Aleksandr , Ponikowski Piotr , Seferovic Petar M , Senni Michele , Shlyakhto Evgeny , Cohen-Solal Alain , Szecsödy Peter , Jensen Klaus , Dorigotti Fabio , Weir Matthew R , Pitt Bertram 
Published: July 2022

Abstract

Aims
To investigate the impact of patiromer on the serum potassium level and its ability to enable specified target doses of renin–angiotensin–aldosterone system inhibitor (RAASi) use in patients with heart failure and reduced ejection fraction (HFrEF).

Methods and results
A total of 1642 patients with HFrEF and current or a history of RAASi-related hyperkalemia were screened and 1195 were enrolled in the run-in phase with patiromer and optimization of the RAASi therapy [≥50% recommended dose of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker/angiotensin receptor-neprilysin inhibitor, and 50 mg of mineralocorticoid receptor antagonist (MRA) spironolactone or eplerenone]. Specified target doses of the RAASi therapy were achieved in 878 (84.6%) patients; 439 were randomized to patiromer and 439 to placebo. All patients, physicians, and outcome assessors were blinded to treatment assignment. The primary endpoint was between-group difference in the adjusted mean change in serum potassium. Five hierarchical secondary endpoints were assessed. At the end of treatment, the median (interquartile range) duration of follow-up was 27 (13–43) weeks, the adjusted mean change in potassium was +0.03 mmol/l in the patiromer group and +0.13 mmol/l in the placebo group [difference in the adjusted mean change between patiromer and placebo: −0.10 mmol/l (95% confidence interval, CI −0.13, 0.07); P &lt; 0.001]. Risk of hyperkalemia &gt;5.5 mmol/l [hazard ratio (HR) 0.63; 95% CI 0.45, 0.87; P = 0.006), reduction of MRA dose (HR 0.62; 95% CI 0.45, 0.87; P = 0.006), and total adjusted hyperkalemia events/100 person-years (77.7 vs. 118.2; HR 0.66; 95% CI 0.53, 0.81; P &lt; 0.001) were lower with patiromer. Hyperkalemia-related morbidity-adjusted events (win ratio 1.53, P &lt; 0.001) and total RAASi use score (win ratio 1.25, P = 0.048) favored the patiromer arm. Adverse events were similar between groups.

Conclusion
Concurrent use of patiromer and high-dose MRAs reduces the risk of recurrent hyperkalemia (ClinicalTrials.gov: NCT03888066).
Relationship between patient-centred care and advance care planning among home medical care patients in Japan: the Zaitaku evaluative initiatives and outcome study
Authors: Hayashi Shinu , Shirahige Yutaka , Fujioka Satoshi , Tsugihashi Yukio , Iida Hidezaku , Hirose Misaki , Yasunaka Masakazu , Kurita Noriaki ,   ZEVIOUS Group
Published: July 2022

AbstractBackgroundThere is a growing need to realize high-quality end-of-life care at home that respects the patient’s wishes.ObjectiveTo examine the association between the quality of primary care and advance care planning (ACP) participation among patients receiving home-based medical care.MethodsIn this multicentre, cross-sectional study, 29 home medical care clinics in Japan were included. Adult Japanese patients receiving home medical care were surveyed to assess their consideration of ACP. The quality of primary care, which reflects patient-centredness, was assessed with the Japanese version of the Primary Care Assessment Tool-Short Form (JPCAT-SF). Information on the clinical conditions that require home medical care was collected from physicians.ResultsOf the 194 patients surveyed from 29 home medical services, 62 patients (32%) showed signs of ACP participation. Lack of opportunities was the most common reason for not participating in the ACP. In a multivariable-adjusted generalized estimating equation, primary care quality was associated with ACP participation (per 10-point increase, adjusted odds ratio: 1.96, 95% confidence interval: 1.51–2.56). In addition, all domains of the JPCAT-SF were associated with ACP participation.ConclusionsPatient-centredness in home medical care facilitates the initiation of ACP participation.
Preliminary investigation of the student-delivered Community Outreach teleheAlth program for Covid education and Health promotion (COACH)
Authors: Yang Michelle C , Clayton Cam , Harris Devin , Pelletier Chelsea , Schmidt Julia , Zwicker Jill G , Sakakibara Brodie M 
Published: July 2022

Abstract

Background
COVID-19 public health restrictions (i.e. physical distancing) compromise individuals’ ability to self-manage their health behaviours and may increase the risks of adverse health events.

Objectives
To evaluate the student-delivered Community Outreach teleheAlth program for Covid education and Health promotion (COACH) on health-directed behaviour (self-management) among older adults (≥65 years of age, n = 75). Secondary objectives estimated the influence of COACH on perceived depression, anxiety, and stress; social support; health-related quality of life; health promotion self-efficacy; and other self-management domains.

Methods
COACH was developed to provide chronic disease management and prevention support among older adults via telephone or videoconferencing platforms (i.e. Zoom). In this single-group, pre-post study, our primary outcome was measured using the health-directed behaviour subscale of the Health Education Impact Questionnaire. Secondary measures included the Depression, Anxiety and Stress Scale, Medical Outcomes Study: Social Support Survey, MOS Short Form-36, and Self-Rated Abilities for Health Practices Scale. Paired sample t-tests were used to analyse outcome changes.

Results
Mean age of participants was 72.4 years (58.7% female; 80% ≥2 chronic conditions). Health-directed behaviour significantly improved after COACH (P &lt; 0.001, d = 0.45). Improved health promotion self-efficacy (P &lt; 0.001, d = 0.44) and decreased mental health were also observed (P &lt; 0.001, d = −1.69).

Discussion
COACH likely contributed to improved health-directed behaviour and health promotion self-efficacy despite the diminished mental health-related quality of life during COVID-19. Our findings also highlight the benefits of using health professional students for the delivery of virtual health promotion programs.

Clinical Trial Information
ClinicalTrials.gov ID: NCT04492527
Role of pressure and pore microstructure on seismic attenuation and dispersion of fluid-saturated rocks: laboratory experiments and theoretical modelling
Authors: He Yan-Xiao , Wang Shangxu , Xi Bo , Tang Genyang , Yin Hanjun , Zhao Liming , Sun Chao , Ma Xiaoyi 
Published: July 2022

SUMMARY
Understanding the effects of pressure and rock microstructure on seismic elastic properties of fully saturated rocks is of considerable importance in a range of geophysical applications, especially at seismic frequency range. A recently proposed theoretical model of squirt attenuation and dispersion can be used to interpret the stress and frequency dependence of elastic properties on the basis of a triple porosity structure. The poroelastic model requires the knowledge of a variety of pore microstructure parameters, in particular, the compliant pores with a discrete distribution of aspect ratio. We performed laboratory measurements of (compressional and shear wave) velocity dispersion and attenuation, associated with the pressure-related closure of compliant pores on three dry and wet sandstones, to verify the effects of squirt flow arising from compressibility heterogeneities in the rock microstructure on the pressure dependence of dynamic elastic moduli and attenuation. Ultrasonic velocities experimentally measured on dry rocks were applied to extract pressure-dependent pore aspect distribution of compliant pores and the effective porosity of three types of pores with distinct aspect ratios, via fitting of the poroelastic model to the pressure dependence of elastic compressibilities. Under the assumption of frequency-independent dry elastic properties, inferred velocities and the associated attenuation of the saturated rocks from the forced oscillation experiments, which are still scarcely investigated, are in fairly good agreement with the predictions of the squirt model of three porosity types at seismic frequencies. The Gassmann's relation was found, nevertheless, underpredicts the ultrasonic saturated velocity measurements. The results validate applicability of the recently developed squirt model to account for dispersion and attenuation of phase velocities at varying effective pressures.
Competitiveness anddynamiccumulative causation in an export-led growing economy
Authors: Dávila-Fernández Marwil J , Oreiro Jose Luis 
Published: July 2022

AbstractThe role of the real exchange rate (RER) in explaining long-run processes of catching-up and falling-behind continues to be a question of central importance among alternative theories of growth and distribution. Existing empirical evidence suggests a positive association between exchange rates in levels and growth, especially in developing countries, though a currency depreciation has adverse effects. While these two elements have been separately incorporated into demand-led growth theories, a comprehensive assessment of the dynamic interaction between them is still missing. This article attempts to fill such a gap in the literature by developing an export-led growth model in which price and non-price competitiveness respond to the level and variation of the RER. In equilibrium, relative prices and the fundamentals of the productive structure are simultaneously determined. A more depreciated exchange rate and higher non-price competitiveness are associated with a higher rate of growth. It is shown that the interplay between a destabilizing force from the goods market, and a stabilizing mechanism from the labor market, might give rise to persistent and endogenous long-run cycles of structural change. The model is used to revisit the historical experience of East Asia (EA) and Latin America (LA) in the post-war period. We show our system fits crucial stylized facts, particularly the tendency of LA to have a more appreciated RER, its lower non-price competitiveness and dynamic economies of scale, and stronger distributive conflict, resulting in less growth and greater volatility.
Generalized Minors and Tensor Invariants
Authors: Le Ian , Luo Sammy 
Published: July 2022

Abstract
In the paper [1], the authors define functions on double Bruhat cells, which they call generalized minors. By relating certain double Bruhat cells to the spaces $\operatorname {Conf}_3 {\mathcal {A}}_G$ and $\operatorname {Conf}_4 {\mathcal {A}}_G$, we give formulas for these generalized minors as tensor invariants. This allows us to verify certain weight identities conjectured in [7]. We then show that the grading of these tensor invariants is equivalent information to the quiver for the cluster structure on $\operatorname {Conf}_3 {\mathcal {A}}_G$. This leads to a simple combinatorial construction of cluster structures on the moduli space of framed local systems ${\mathcal {X}}_{G^{\prime},S}$ and ${\mathcal {A}}_{G,S}$.
Comparative biological network analysis for differentially expressed proteins as a function of bacilysin biosynthesis in Bacillus subtilis
Authors: Kutnu Meltem , İşlerel Elif Tekin , Tunçbağ Nurcan , Özcengiz Gülay 
Published: July 2022

Abstract
The Gram-positive bacterium Bacillus subtilis produces a diverse range of secondary metabolites with different structures and activities. Among them, bacilysin is an enzymatically synthesized dipeptide that consists of L-alanine and L-anticapsin. Previous research by our group has suggested bacilysin’s role as a pleiotropic molecule in its producer, B. subtilis PY79. However, the nature of protein interactions in the absence of bacilysin has not been defined. In the present work, we constructed a protein–protein interaction subnetwork by using Omics Integrator based on our recent comparative proteomics data obtained from a bacilysin-silenced strain, OGU1. Functional enrichment analyses on the resulting networks pointed to certain putatively perturbed pathways such as citrate cycle, quorum sensing and secondary metabolite biosynthesis. Various molecules, which were absent from the experimental data, were included in the final network. We believe that this study can guide further experiments in the identification and confirmation of protein–protein interactions in B. subtilis.