bluuebunny/crossref_metadata_2025_split huggingface dataset:
Online survey comparing coping responses to SARS-CoV-2 by people with and without existing health conditions in the UK
Authors: Hewitt Rachael Marie , Pattinson Rachael , Daniel Rhian , Carrier Judith , Sanders Oliver , Bundy Christine 
Published: February 2022

ObjectivesTo investigate the impact of SARS-CoV-2 on self-reported mood, coping and health behaviours of people living with existing health conditions in the UK to understand how to improve coping responses to the threat of SARS-CoV-2.DesignQuantitative design using a cross-sectional survey.SettingOnline survey in the UK.ParticipantsUK adults (18+ years) were eligible to participate. A total of 9110 people participated. Of these, 4377 (48%) reported at least one existing health condition, 874 (10%) reported having two or more existing conditions, and 715 (8%) reported having an existing mental health condition.Primary and secondary outcome measuresMultivariable linear regression and sequential multiple mediation analysis were used to estimate differences in average scores for active and avoidant coping response scores due to pre-existing health conditions, and to investigate the extent to which these differences are explained by differences in perceptions, beliefs, concerns and mood.ResultsPeople with pre-existing physical (+1.11 higher; 95% CI 0.88 to 1.34) and especially mental health conditions (3.06 higher; 95% CI 2.65 to 3.48) reported poorer health and used more avoidant coping compared with healthy participants. Under some strong untestable assumptions, we estimate that experiencing low mood or concern related to SARS-CoV-2 mostly explained the relationship between existing health conditions and avoidant coping.ConclusionPsychological support and interventions including behaviour change are required to mitigate the psychological burden of the SARS-CoV-2 pandemic and increase autonomy in people with and without pre-existing conditions during this highly uncertain time. Psychologists are well placed to support clinicians and people with existing health conditions to minimise the psychological impact of SARS-CoV-2, in order to alleviate the subsequent strain on healthcare services.
Risk of poor mental health and experience of violence among a young adult population with same-sex sexuality: a cross-sectional study in southern Sweden
Authors: Agardh Charlotte , Asamoah Benedict Oppong , Herder Tobias , Larsson Markus 
Published: February 2022

ObjectivesTo assess prevalence and correlates of same-sex sexuality and its relationship to poor mental health and experiences of violence among youth and young adults in Sweden. A secondary aim was to estimate the same-sex sexuality attributable fractions.DesignA population-based cross-sectional survey.SettingSouthern Sweden.Participants2968 respondents out of 7000 youth and young adults between 18 and 29 years old, resident in southern Sweden, selected randomly by the Swedish Central Population Registry (final sample=2931 respondents, 318 with same-sex sexuality and 2613 without).Outcome measuresThe outcome measures were self-reported poor mental health (depression and anxiety) and experience of violence (physical violence, sexual violence and sexual coercion).ResultsIncreased odd of high scores of depression (adjusted OR 1.8, 95% CI 1.39 to 2.26) and anxiety (adjusted OR 1.6, 95% CI 1.28 to 2.07) were observed among youth and young adults with same-sex sexuality. Similarly, increased odds of experience of physical violence (OR 1.8, 95% CI 1.23 to 2.51), sexual violence (OR 2.8, 95% CI 1.96 to 3.89) and sexual coercion (OR 2.5, 95% CI 1.95 to 3.30) were observed with same-sex sexuality. Within the entire young population, same-sex sexuality accounted for 4.7% and 4.1% of the self-reported experience of depression and anxiety, respectively. The estimated same-sex sexuality attributable fractions of violence within the entire population of young people were 4.5% for physical violence, 7.3% for sexual violence and 6.4% for sexual coercion.ConclusionsThis study findings suggest that same-sex sexuality is associated with poor self-rated mental health and experience of violence among youth and young adults in Sweden. Some differences were observed between males and females, indicating that the vulnerabilities and experiences vary between young males and females. Further research is needed in order to gain a deeper knowledge of the factors underlying these associations and the gender differences observed.
Global status of essential medicine selection: a systematic comparison of national essential medicine lists with recommendations by WHO
Authors: Piggott Thomas , Nowak Artur , Brignardello-Petersen Romina , Cooke Graham S , Huttner Benedikt , Schünemann Holger J , Persaud Nav , Magrini Nicola , Moja Lorenzo 
Published: February 2022

ObjectivesExamining the availability of essential medicines is a necessary step to monitor country-level progress towards universal health coverage. We compared the 2017 essential medicine lists (EML) of 137 countries to the WHO Model List to assess differences by drug class and country setting.MethodsWe extracted all medicines prioritised at country level from most recently available national EMLs and compared each national EML with the 2017 WHO Model List of Essential Medicines (MLEM) as the reference standard. We assess EMLs by WHO region and for different types of medicine subgroups (eg, cancer, anti-infectives, cardiac, psychiatric and anaesthesia medicines) using within second-level anatomical therapeutic class (ATC) drug classes of the ATC Index.ResultsWe included 406 medicines from WHO’s 2017 MLEM to compare to 137 concurrent national EMLs. We found a median of 315 (range from 44 to 983) medicines listed on national EMLs. The global median F1 score was 0.59 (IQR 0.47–0.70, maximum possible score indicating alignment with MLEM is 1). The F1 score was the highest (ie, most similar to MLEM) in the South-East Asia region and the lowest in the European region (ie, most dissimilar to MLEM). The F1 score was highest for stomatological preparations (median: 1.00), gynaecological—anti-infectives and antiseptics (median: 1.00), and medicated dressings (median: 1.00), and lowest for 9 anatomical or pharmacological groups (median: 0.00, eg, treatments for bone diseases, digestive enzymes).ConclusionsMost countries are expected to improve their national health coverage by 2030 offering access to essential medicines, but our results revealed substantial gaps in selection of medicines at the national level compared with those recommended by WHO. It is crucial that governments consider investing in those effective medicines that are now neglected and continue monitoring progress towards essential medicine access as part of universal health coverage.
Protocol for a prospective open-label clinical trial to investigate the utility of concurrent TBS/fNIRS for antidepressant treatment optimisation
Authors: Kan Rebecca L D , Mak Arthur D P , Chan Sherry K W , Zhang Bella B B , Fong Kenneth N K , Kranz Georg S 
Published: February 2022

IntroductionRepetitive transcranial magnetic stimulation (rTMS) with theta burst stimulation (i.e. TBS) of the dorsolateral prefrontal cortex (DLPFC) is an innovative treatment for major depressive disorder (MDD). However, fewer than 50% of patients show sufficient response to this treatment; markers for response prediction are urgently needed. Research shows considerable individual variability in the brain responses to rTMS. However, whether differences in individual DLPFC modulation by rTMS can be used as a predictive marker for treatment response remains to be investigated. Here, we present a research programme that will exploit the combination of functional near-infrared spectroscopy (fNIRS) with brain stimulation. Concurrent TBS/fNIRS will allow us to systematically investigate TBS-induced modulation of blood oxygenation as a proxy for induced brain activity changes. The findings from this study will (1) elucidate the immediate effects of excitatory and inhibitory TBS on prefrontal activity in TBS treatment-naïve patients with MDD and (2) validate the potential utility of TBS-induced brain modulation at baseline for the prediction of antidepressant response to 4 weeks of daily TBS treatment.Methods and analysisOpen-label, parallel-group experiment consisting of two parts. In part 1, 70 patients and 37 healthy controls will be subjected to concurrent TBS/fNIRS. Intermittent TBS (iTBS) and continuous TBS (cTBS) will be applied on the left and right DLPFC, respectively. fNIRS data will be acquired before, during and several minutes after stimulation. In part 2, patients who participated in part 1 will receive a 4 week iTBS treatment of the left DLPFC, performed daily for 5 days per week. Psychometric evaluation will be performed periodically and at 1 month treatment follow-up. Statistical analysis will include a conventional, as well as a machine learning approach.Ethics and disseminationEthics approval was obtained from the Institutional Review Board. Findings will be disseminated through scientific journals, conferences and university courses.Trial registration numberNCT04526002.
Drag and pressure pulsation reduction of a low-specific-speed centrifugal pump by employing bionic structure
Authors: Cui Bao-Ling , Wang Zhen , Zhang Ying-Bin , Han Xiao-Tian 
Published: February 2022

To improve the performance of a low-specific-speed centrifugal pump, the bionic structure extracted from the dung beetle was distributed on the blade surface to reduce the drag. The flow fields in the centrifugal pumps with and without the bionic structure blade were calculated based on the RNG [Formula: see text]–[Formula: see text] turbulence model. The results showed that the bionic structure can reduce the energy loss and improve the hydraulic efficiency of the centrifugal pump, with a maximum increase of 5%. The bionic structure can affect the turbulence structure of the boundary layer near the wall and reduce the blade outlet velocity gradient and wall shear, thereby improving the pressure pulsation characteristics of the centrifugal pump. With the increase in flow, the drag reduction gradually becomes evident for the impeller with a bionic structure.
Impact of statin use on major adverse cardiovascular events in patients with normal stress myocardial perfusion imaging and elevated coronary artery calcium score
Authors: To Yi Hui , Tan Xi Min , Low Cher-Lyn , Min Htet Htet , Yew Min Sen 
Published: February 2022

Introduction:
Normal stress myocardial perfusion imaging (MPI) carries a favourable prognosis. Conversely, elevated coronary artery calcium (CAC) is associated with increased major adverse cardiovascular events (MACE). There is limited information on the prognosis and management of patients with elevated CAC and normal MPI. We aimed to assess the outcomes of patients with elevated CAC and normal MPI in relation to post-MPI statin use.

Methods:
A retrospective review of normal MPI with CAC score >300 was performed between 1 March 2016 and 31 January 2017 in a Singapore tertiary hospital. Patients with known atherosclerotic cardiovascular disease or left ventricular ejection fraction <50% on MPI were excluded. Patient demographics, prescriptions and MACE (cardiac death, nonfatal myocardial infarction and/or ischaemic stroke) at 24 months after MPI were traced using electronic records. Binary logistic regression was used to evaluate for independent predictors of MACE.

Results:
We included 311 patients (median age 71 years, 56.3% male), of whom 65.0% were on moderate to high-intensity statins (MHIS) after MPI. MACE was significantly lower in the post-MPI MHIS group (3.5% vs. 9.2%, P = 0.035). On univariate binary logistic regression, post-MPI MHIS use was the only significant predictor for MACE (odds ratio [OR] 0.355 [95% confidence interval (CI) 0.131–0.962], P = 0.042), even after multivariate adjustment (adjusted OR 0.363, 95% confidence interval 0.134–0.984, P = 0.046).

Conclusion:
Post-MPI MHIS use is associated with lower MACE and is an independent negative predictor for 24-month MACE among patients with normal MPI and CAC >300.
Calculated parameters for the diagnosis of Wilson disease
Authors: Zulkufli Nada Syazana , Sthaneshwar Pavai , Chan Wah-Kheong 
Published: February 2022

Introduction:
The diagnosis of Wilson disease (WD) is plagued by biochemical and clinical uncertainties. Thus, calculated parameters have been proposed. This study aimed to: (a) compare the diagnostic values of non-caeruloplasmin copper (NCC), NCC percentage (NCC%), copper-caeruloplasmin ratio (CCR) and adjusted copper in WD; and (b) derive and evaluate a discriminant function in diagnosing WD.

Methods:
A total of 213 subjects across all ages who were investigated for WD were recruited. WD was confirmed in 55 patients, and the rest were WD free. Based on serum copper and caeruloplasmin values, NCC, NCC%, CCR and adjusted copper were calculated for each subject. A function was derived using discriminant analysis, and the cut-off value was determined through receiver operating characteristic analysis. Classification accuracy was found by cross-tabulation.

Results:
Caeruloplasmin, total copper, NCC, NCC%, CCR, adjusted copper and discriminant function were significantly lower in WD compared to non-WD. Discriminant function showed the best diagnostic specificity (99.4%), sensitivity (98.2%) and classification accuracy (99.1%). Caeruloplasmin levels <0.14 g/L showed higher accuracy than the recommended 0.20 g/L cut-off value (97.7% vs. 87.8%). Similarly, molar NCC below the European cut-off of 1.6 umol/L showed higher accuracy than the American cut-off of 3.9 umol/L (80.3% vs. 59.6%) (P < 0.001). NCC%, mass NCC, CCR and adjusted copper showed poorer performances.

Conclusion:
Discriminant function differentiates WD from non-WD with excellent specificity, sensitivity and accuracy. Performance of serum caeruloplasmin <0.14 g/L was better than that of <0.20 g/L. NCC, NCC%, CCR and adjusted copper are not helpful in diagnosing WD.
ORDER VS JUSTICE IN THE MIDDLE EAST
Authors: Hama Hawre Hasan 
Published: February 2022

This article analyzes the Kurdish question in the Middle East from the English School perspective in international relations. The central argument is that the international community consistently deals with the Kurdish question through the principle of order rather than justice. It has respected the sovereignty of those nation‐states hosting the Kurds rather than protecting the Kurdish population from grave human rights violations. Consequently, the Kurds have failed to achieve a semblance of autonomy, let alone independence. However, I argue that while the implementation of the no‐fly‐zone over northern Iraq in 1991 by the international community is a case for justice, it is not necessarily a case against the principle of order. In other words, the international community only dealt with the Kurdish issue using the principle of justice when implementing the 1991 no‐fly‐zone—but, notably, this was not against the principle of order.
Comparison between Del Nido and conventional blood cardioplegia in pediatric open-heart surgery
Authors: Floh Alejandro A , Das Shubhadeep , Haranal Maruti , Laussen Peter C , Crawford-Lean Lynn , Fan Chun-Po S , Mertens Luc L , Runeckles Kyle , Honjo Osami 
Published: February 2022

Background Del Nido cardioplegia (DNc) was designed for superior myocardial protection during cardiopulmonary bypass (CPB). We conducted a retrospective review to explore if DNc was associated with increase in systemic ventricle dysfunction (sVD) following pediatric CPB. Methods and Results This single-center, retrospective study included 1534 patients undergoing CPB between 2013 and 2016, 997 prior to center-wide conversion to DNc and 537 following. The primary outcome was new postoperative ≥moderate sVD by echocardiogram. Secondary outcomes included sVD of any severity and right ventricular dysfunction. Data was evaluated by interrupted time-series analysis. Groups had similar cardiac diagnoses and surgical complexity. Del Nido cardioplegia was associated with longer median (IQR) CPB [117 (84–158) vs 108 (81–154), p = 0.04], and aortic cross-clamp [83 (55–119) vs 76 (53–106), p = 0.03], and fewer cardioplegia doses [2 (1–2) vs 3 (2–4), p < 0.0001]. Mortality was similar in both groups. Frequency of sVD was unchanged following DNc, including predetermine subgroups (neonates, infants, and prolonged cross-clamp). Logistic regression showed a significant rise in right ventricular dysfunction (OR 5.886 [95% CI: 0.588, 11.185], p = 0.03) but similar slope. Conclusions Use of DNc was not associated with increased in reported sVD, and provided similar myocardical protection to the systemic ventricle compared to conventional cardioplegia but may possibly impact right ventricular function. Studies evaluating quantitative systolic and diastolic function are needed.
Improved sintering performance of β-SiAlON–Si3N4 and its osteogenic differentiation ability by adding β-SiAlON
Authors: Mu Jinghua , Zhang Liguo , Zhang Can , Xu Enxia , Wang Lulu , Liu Xinhong , Chang Guanglei , Sun Xu , Ma Chengliang , Yuan Huiyu , Zhao Fei , Gao Jinxing 
Published: February 2022

To improve the sintering performance of silicon nitride bioceramics, we explored the effect of β-SiAlON’s Z-value on the physical, chemical, and biological properties of β-SiAlON–Si3N4 composites. Results showed that the phase product was β-Si3N4. As the Z-value increased, the X-ray diffraction peaks gradually shifted to a smaller angle, the material grains were more tightly packed, and the bulk density and compressive strength increased, reaching the highest values (2.71 g/cm3 and 1157 MPa, respectively) at Z = 4. Soaking and ion-release experiments show that in an aqueous environment, a small amount of Al and Si ions were released, and no obvious decomposition occurred on the surface of the material. The biological performance showed that the growth of cultured cells in each group was in good condition, there was no obvious difference in morphology and adhesion, and the materials had good biological performance. An increase in the Z-value promotes the formation of mineralized nodules and osteogenic differentiation of MC3T3-E1 cells, which may be because the release of Si can promote osteogenic differentiation. Therefore, the addition of β-SiAlON could improve the sintering performance of β-Si3N4 without degrading its biological properties. The prepared β-SiAlON–Si3N4 composite ceramic is a latent bioceramic material.
The Macroeconomic Impact of Fiscal Policy Shocks: What do the Indian Data Say?
Authors: Sobti Riddhima 
Published: February 2022

This article examines the impact of fiscal policy shocks on a set of macroeconomic variables in India, using a seasonally adjusted quarterly dataset for the period 2003–2019. The Gregory-Hansen residual-based test for cointegration and the vector error correction model (VECM) are applied, and impulse responses based on a recursive identification scheme (Cholesky decomposition) is used to assess the effects of a gross tax revenue shock and a government spending shock on economic activity, while accounting for the possibility of structural breaks. The findings indicate that an unexpected fiscal policy shock has an immediate expansionary impact on real GDP and a sudden positive effect on inflation (WPI) and the repo rate; and that the impact is permanent and away from the zero equilibrium. The careful design of policies by the central bank and the government as crucial macroeconomic stabilisation tools is imperative. JEL Classification: E6, H20, H30
Efficacy of excision versus ablation for improving endometriosis related pain: A systematic review and meta-analysis
Authors: Ouyang Chensi , Fitch Amy , Cho Kelly S , Driscoll Jenna , Wang Alexander , Lamvu Georgine 
Published: February 2022

Background: Surgical treatment of superficial peritoneal endometriosis includes excision or ablation. Controversy exists about which method is better for providing pain relief. We performed a meta-analysis of randomized control trials (RCTs) comparing the efficacy of excision versus ablation for improving the most frequently encountered endometriosis pain symptoms: dysmenorrhea, dyspareunia, non-cyclic pelvic pain, and dyschezia. Methods: A search from inception to May 2020 was conducted in PubMed, MEDLINE, Clinicaltrials.gov, Cochrane Central Register of Controlled Trials, and Web of Science. RCTs comparing excision versus ablation for peritoneal endometriosis were included if they assessed dysmenorrhea, dyspareunia, dyschezia, and pelvic pain/non-menstrual pain. Exclusion criteria included extra-peritoneal endometriosis or endometriomas, and non-English publications. Publications were assessed for risk of bias and quality of evidence using Cochrane risk of bias tool (RoB 2) and GradePro. Results: Of the 2025 records identified initially, four met inclusion criteria. The sample sizes of the included studies ranged from 24 to 133 participants. The excision and ablation groups included 204 participants each. There was no difference after excision or ablation for dysmenorrhea when comparing the mean change in pain scores from baseline to 12 months after surgery (−0.31, 95% CI −1.66, 1.04, p = 0.65), dyspareunia (−0.24, 95% CI −1.78, 1.30, p = 0.76), dyschezia (−0.72, 95% CI −1.94, 0.50, p = 0.25), or non-cyclic pain (−0.78, 95% CI −2.47, 0.91, p = 0.37). Conclusions: We found low to moderate quality evidence suggesting that neither excision nor ablation is superior in reduction of endometriosis-related pain up to 12 months after surgery.
Measuring circularity: evaluation of the circularity of construction products using the ÖKOBAUDAT database
Authors: Dräger Philipp , Letmathe Peter , Reinhart Linda , Robineck Florian 
Published: February 2022

Abstract
Background
Owing to the large amounts of energy, greenhouse gases, and waste that it generates, the construction industry is fundamental to the transition towards a circular economy. Indicators which show the circularity of products—and thus make them comparable with each other—can be used to support the implementation of such an economy. In this article, we have adapted the material circularity indicator of the Ellen MacArthur Foundation in order to analyze the circularity of construction products available in the German environmental database ÖKOBAUDAT.

Results
The adapted indicator is applied to 89 building products from the categories of insulation materials, plastics, metals, and mineral building materials. More than half of the products receive the lowest score of 0.10, indicating poor implementation of circular strategies in the German construction industry to date.

Conclusion
Circular material flows are most likely to be employed for metals. However, the overall low circularity scores indicate a big need for better implementing circularity strategies.