bluuebunny/crossref_metadata_2025_split huggingface dataset:
Financial managers and organizational ambidexterity in the German Mittelstand: the moderating role of strategy involvement
Authors: Weigel Christine , Derfuss Klaus , Hiebl Martin R. W. 
Published: March 2022

AbstractRelying on the upper-echelons perspective, this paper investigates the effect of financial managers’ characteristics on the level of organizational ambidexterity reached in German Mittelstand firms. These firms are often depicted as highly innovative and able to compete on worldwide markets despite significant resource constraints. We theorize that skilled financial managers are very important in making the optimal use of Mittelstand firms’ scarce resources and, in particular, for balancing exploitation and exploration, thus reaching high levels of ambidexterity. Our findings from a survey of German Mittelstand firms broadly confirm our expectations and show that financial managers’ individual entrepreneurial behavior correlates positively with the firms’ level of organizational ambidexterity. In addition, we find that firms with financial managers having enjoyed business education are more likely to reach high levels of ambidexterity if these financial managers are heavily involved in strategy development. Overall, these results indicate that well-suited financial managers are an important human resource for Mittelstand firms. In addition, our findings are among the first to show that financial managers not only influence finance and accounting choices, but also innovation-related outcomes such as organizational ambidexterity.
Recent Advances in Anticancer Activity of Novel Plant Extracts and Compounds from Curcuma longa in Hepatocellular Carcinoma
Authors: Gull Nighat , Arshad Fareeha , Naikoo Gowhar A. , Hassan Israr Ul , Pedram Mona Zamani , Ahmad Arif , Aljabali Alaa A. A. , Mishra Vijay , Satija Saurabh , Charbe Nitin , Negi Poonam , Goyal Rohit , Serrano-Aroca Ángel , Al Zoubi Mazhar S. , El-Tanani Mohamed , Tambuwala Murtaza M. 
Published: March 2022

Abstract
Purpose
Among all forms of cancers, hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. There are several treatment options for HCC ranging from loco-regional therapy to surgical treatment. Yet, there is high morbidity and mortality. Recent research focus has shifted towards more effective and less toxic cancer treatment options. Curcumin, the active ingredient in the Curcuma longa plant, has gained widespread attention in recent years because of its multifunctional properties as an antioxidant, anti-inflammatory, antimicrobial, and anticancer agent.

Methods
A systematic search of PubMed, Embase and Google Scholar was performed for studies reporting incidence of HCC, risk factors associated with cirrhosis and experimental use of curcumin as an anti-cancer agent.

Results
This review exclusively encompasses the anti-cancer properties of curcumin in HCC globally and it’s postulated molecular targets of curcumin when used against liver cancers.

Conclusions
This review is concluded by presenting the current challenges and future perspectives of novel plant extracts derived from C. longa and the treatment options against cancers.
Association Between Antibiotic Overexposure and Adverse Outcomes in Very-Low-Birth-Weight Infants Without Culture-Proven Sepsis or Necrotizing Enterocolitis: A Multicenter Prospective Study
Authors: Hou Shanshan , Yu Yonghui , Wu Yanqiu , Cao Yangyang , Zhang Jinghui , Liu Zhijie , Guo Cheng , Chen Yao , Sun Xuemei , Li Min , Gao Yanling , Zhao Guoying , Niu Shiping , Zhou Zhiyuan , Wang Yu , Yang Zhenying , Huang Lei , Zhang Chengyuan , Chen Tong , Zhao Xinfeng , Li Xia , Zhang Yongfeng , Zhao Peng , Bi Meirong , Zhao Riming 
Published: March 2022

Abstract
Objectives
To explore the associations between higher antibiotic use rates (AURs) and adverse outcomes in very-low-birth-weight (VLBW) infants without culture-proven sepsis or necrotizing enterocolitis (NEC) in a multicenter of China.

Methods
A prospective cohort study was performed on VLBW infants admitted to 24 neonatal intensive care units from January 1, 2018, to December 31, 2018. AUR was calculated as calendar days of antibiotic therapy divided by total hospital days. The composite primary outcome was defined as mortality or severe morbidity, including any of the following: severe neurologic injury, bronchopulmonary dysplasia (BPD), and stage 3 or higher retinopathy of prematurity.

Results
A total of 1,034 VLBW infants who received antibiotics without culture-proven sepsis or NEC were included in this study. The overall AUR of eligible VLBW infants was 55%, and the AUR of each eligible VLBW infant ranged from 3 to 100%, with a median of 56% (IQR 33%, 86%). After generalized propensity score and logistic regression analysis of 4 groups of VLBW infants with different AUR range, infants in the higher quartile AUR, (Q3, 0.57~0.86) and (Q4, 0.87~1.00), had higher odds of composite primary outcome (adjusted OR: 1.81; 95% CI: 1.23–2.67; adjusted OR 2.37; 95% CI: 1.59–3.54, respectively) and BPD (adjusted OR: 3.09; 95% CI: 1.52–6.57; adjusted OR 3.17; 95% CI: 1.56–6.57, respectively) than those in the lowest AUR (Q1).

Conclusions
Antibiotic overexposure in VLBW infants without culture-proven sepsis or NEC was associated with increased risk of composite primary outcome and BPD. Rational empirical antibiotic use in VLBW infants is urgently needed in China.
Effect of fire on viability and germination behaviour of Cistus ladanifer and Cistus salvifolius seeds
Authors: Aguayo-Villalba Antonio Ángel , Álvarez-Gómez Concepción María , Aisa-Ahmed Mimunt , Barroso-Rodríguez Laura María , Camacho-López Samuel , Cocero-Ramírez Agustín , Sánchez-Romero Carolina 
Published: March 2022

AbstractFire is a natural phenomenon that is very frequent in ecosystems of the Mediterranean basin.Cistus ladaniferandC. salvifolius(Cistaceaefamily) are evergreen shrubs and components of plant communities found in this region. The objective of this study was to evaluate the effect of fire on the germination ofC. ladaniferandC. salvifoliusseeds. For this purpose, seeds of both species were subjected to different heat-shock treatments simulating natural fire conditions (50–175°C for 1 and 5 min). To elucidate the ecological significance of the effects of fire, viability and different traits informative about the dynamics of the germination process, such as final germination percentage (FGP), first day of germination (FDG), last day of germination (LDG), time spread of germination (TSG) and coefficient of velocity of germination (CVG), were determined. Seeds of both species exhibited fire-related behaviour, as they showed seed heat resistance and heat-stimulated germination. Germination in control, untreated seeds was very low, with 10 and 0% FGP forC. ladaniferandC. salvifolius, respectively. Thermal treatments significantly increased germination in both cases, with optimal results achieved at 100–125°C for 1 min and 75–100°C for 5 min. Under these conditions, greater germination percentages were obtained inC. salvifolius(92–95%) than inC. ladanifer(64–68%). Temperature proved to have a greater influence on seed viability and germination than the accumulated heat dose. The pattern of seed germination varied depending on the species and the heat shock treatments. In general,C. ladaniferexhibited earlier and faster germination. These characteristics, along with the high number of seeds produced per plant, makeC. ladanifera more competitive species for colonizing empty spaces after fire.
Changes in processing characteristics and microstructural evolution during friction extrusion of aluminum
Authors: Halak Ricardo M. , Rath Lars , Suhuddin Uceu F. H. R. , dos Santos Jorge F. , Klusemann Benjamin 
Published: March 2022

AbstractThis study focuses on characterizing the microstructural evolution of the aluminum alloy 7075 in the friction extrusion process under different extrusion forces and die angles. Depending on these conditions, two fundamentally different extrusion types are found, showing significant differences in the process characteristics and microstructural evolution. One of the two extrusion types is associated with high extrusion force and low die angle, leading to fully recrystallized wires with average grain size around 1.2 $$\upmu$$
μ
m. The microstructural analysis indicates that the microstructure present in the wires is generated in the charge material by the combination of tool geometry, load induced material flow and friction conditions in the initial stages of the friction extrusion process. The identified processing conditions and influencing factors introduce an alternative route for friction extrusion at low extrusion ratios, capable of producing completely refined wires.
Ru-functionalized Ni-doped dual phases of α/γ-Fe2O3 nanosheets for an optimized acetone detection
Authors: Tian Ruonan , Gao Zeyuan , Lang Ruifeng , Li Na , Gu Huilin , Chen Gang , Guan Hongtao , Comini Elisabetta , Dong Chengjun 
Published: March 2022

AbstractLately novel strategies to enhance the sensing properties on iron oxide have been proposed to achieve high performance gas sensors for acetone detection. In this working report, the synthesis of iron-glycerate (Fe-Gly) using glycerol to combine with Fe3+ is first presented. Depending on the thermal treatment, this compound can evolve into γ-Fe2O3, α/γ-Fe2O3 and α-Fe2O3. α/γ-Fe2O3 shows better sensing performance as far as acetone detection is concerned. Using the dual phases of α/γ-Fe2O3 as a fundamental building block, their sensing properties were further improved using Ni doping and Ru nanoparticles functionalization. The high response and selectivity to acetone detection was ascribed to the synergistic effects of unique nanosheets, mixed phases, rich oxygen vacancies and excellent catalytic activity of Ru nanoparticles.
Graphical abstract
Isotype Heterojunction-Boosted CO2 Photoreduction to CO
Authors: Ban Chaogang , Duan Youyu , Wang Yang , Ma Jiangping , Wang Kaiwen , Meng Jiazhi , Liu Xue , Wang Cong , Han Xiaodong , Cao Guozhong , Gan Liyong , Zhou Xiaoyuan 
Published: March 2022

AbstractPhotocatalytic conversion of CO2 to high-value products plays a crucial role in the global pursuit of carbon–neutral economy. Junction photocatalysts, such as the isotype heterojunctions, offer an ideal paradigm to navigate the photocatalytic CO2 reduction reaction (CRR). Herein, we elucidate the behaviors of isotype heterojunctions toward photocatalytic CRR over a representative photocatalyst, g-C3N4. Impressively, the isotype heterojunctions possess a significantly higher efficiency for the spatial separation and transfer of photogenerated carriers than the single components. Along with the intrinsically outstanding stability, the isotype heterojunctions exhibit an exceptional and stable activity toward the CO2 photoreduction to CO. More importantly, by combining quantitative in situ technique with the first-principles modeling, we elucidate that the enhanced photoinduced charge dynamics promotes the production of key intermediates and thus the whole reaction kinetics.
Prospective-randomized study comparing clinical outcomes of IVF treatments where embryos were cultured individually or in a microwell group culture dish
Authors: Fancsovits Peter , Pribenszky Csaba , Lehner Adam , Murber Akos , Kaszas Zita , Nemes Annamaria , Urbancsek Janos 
Published: March 2022

AbstractCulturing embryos together in a microdrop of media may improve embryo quality, based on the results of animal studies, however individual identification of the embryos in such a system is not possible. The microwell group culture dish contains 9 or 16 microwells with a minimal well-to-well distance and a specific well morphology that facilitates paracrine and autocrine effects. The microwell group culture dish enables individual identification of the embryos while providing the environment that comes with similar benefits as group culture. Our aim was to investigate whether embryo culture in the microwell group culture dish (Primo Vision Dish, Vitrolife) improves IVF outcomes compared to individual culture in human IVF treatment. Five hundred thirty-two IVF-ET cycles were enrolled in this prospective randomized study in a university hospital. IVF cycles were randomized into microwell group culture and individual culture groups. Primary outcome measure was clinical pregnancy rate and secondary outcome measures were embryo quality, fertilization, implantation, delivery and embryo utilization rates. Fertilization rate in ICSI cycles was significantly higher in the microwell group culture group (70.6% vs. 64.9%, P = 0.001). Clinical pregnancy rate was 50.8% in the group culture and 40.6% in the individual culture (P = 0.022). Live birth rate was 41.5% in microwell and 32.9% in individual culture (P = 0.0496). Embryo utilization rate was higher in microwell group culture than in individual culture (80.6% vs. 75.0%; P < 0.001). Microwell group culture has a beneficial effect on IVF outcome and it also allows following up individual embryo development.ClinicalTrials.gov: NCT01774006.
DeepCAGE: Incorporating Transcription Factors in Genome-Wide Prediction of Chromatin Accessibility
Authors: Liu Qiao , Hua Kui , Zhang Xuegong , Wong Wing Hung , Jiang Rui 
Published: March 2022

Abstract
Although computational approaches have been complementing high-throughput biological experiments for the identification of functional regions in the human genome, it remains a great challenge to systematically decipher interactions between transcription factors (TFs) and regulatory elements to achieve interpretable annotations of chromatin accessibility across diverse cellular contexts. To solve this problem, we propose DeepCAGE, a deep learning framework that integrates sequence information and binding statuses of TFs, for the accurate prediction of chromatin accessible regions at a genome-wide scale in a variety of cell types. DeepCAGE takes advantage of a densely connected deep convolutional neural network architecture to automatically learn sequence signatures of known chromatin accessible regions and then incorporates such features with expression levels and binding activities of human core TFs to predict novel chromatin accessible regions. In a series of systematic comparisons with existing methods, DeepCAGE exhibits superior performance in not only the classification but also the regression of chromatin accessibility signals. In a detailed analysis of TF activities, DeepCAGE successfully extracts novel binding motifs and measures the contribution of a TF to the regulation with respect to a specific locus in a certain cell type. When applied to whole-genome sequencing data analysis, our method successfully prioritizes putative deleterious variants underlying a human complex trait and thus provides insights into the understanding of disease-associated genetic variants. DeepCAGE can be downloaded from https://github.com/kimmo1019/DeepCAGE.
Forgiveness, Repentance, and Diachronic Blameworthiness
Authors: KHOURY ANDREW C. 
Published: March 2022

AbstractMany theorists have found the notion of forgiveness to be paradoxical, for it is thought that only the blameworthy can be appropriately forgiven but that the blameworthy are appropriately blamed, not forgiven. Some have appealed to the notion of repentance to resolve this tension. But others have objected that such a response is explanatorily inadequate in the sense that it merely stipulates and names a solution leaving the transformative power of repentance unexplained. Worse still, others have objected that such a response cannot succeed because no amount of repentance can render the blameworthy not blameworthy. I argue that this latter objection is based on a mistaken assumption, the acknowledgement of which has the power to resolve the paradox in a way that meets the explanatory adequacy challenge and, more generally, has significant implications with which any full theory of forgiveness must engage.
A Neo-Searlean Theory of Intentionality
Authors: Georgalis Nicholas 
Published: March 2022

AbstractI present Searle’s theory of intentionality and defend it against some objections. I then significantly extend his theory by exposing and incorporating an ambiguity in the question as to what an intentional state is about as between a subjective and an objective reading of the question. Searle implicitly relies on this ambiguity while applying his theory to a solution to the problem of substitution in propositional attitudes, but his failure to explicitly accommodate the ambiguity undermines his solution. My extension of his theory succeeds. I also indicate how the new theory can be deployed to resolve other outstanding problems.
Characterising englacial R-channels using artificial moulins
Authors: Pohle Annegret , Werder Mauro A. , Gräff Dominik , Farinotti Daniel 
Published: March 2022

AbstractThe englacial and subglacial drainage systems exert key controls on glacier dynamics. However, due to their inaccessibility, they are still only poorly understood and more detailed observations are important, particularly to validate and tune physical models describing their dynamics. By creating artificial glacier moulins – boreholes connected to the subglacial drainage system and supplied with water from surface streams – we present a novel method to monitor the evolution of an englacial hydrological system with high temporal resolution. Here, we use artificial moulins as representations for vertical, pressurised, englacial R-channels. From tracer and pressure measurements, we derive time series of the hydraulic gradient, discharge, flow speed and channel cross-sectional area. Using these, we compute the Darcy–Weisbach friction factor, obtaining values which increase from 0.1 to 13 within five days of channel evolution. Furthermore, we simulate the growth of the cross-sectional area using different temperature gradients. The comparison to our measurements largely supports the common assumption that the temperature follows the pressure melting point. The deviations from this behaviour are analysed using various heat transfer parameterisations to assess their applicability. Finally, we discuss how artificial moulins could be combined with glacier-wide tracer experiments to constrain parameters of subglacial drainage more precisely.
MODEL THEORY OF FIELDS WITH FINITE GROUP SCHEME ACTIONS
Authors: HOFFMANN DANIEL MAX , KOWALSKI PIOTR 
Published: March 2022

AbstractWe study model theory of fields with actions of a fixed finite group scheme. We prove the existence and simplicity of a model companion of the theory of such actions, which generalizes our previous results about truncated iterative Hasse–Schmidt derivations [13] and about Galois actions [14]. As an application of our methods, we obtain a new model complete theory of actions of a finite group on fields of finite imperfection degree.
Antarctic representation in print media during the emergence of COVID-19
Authors: Alexander Karen A. , Marx Katie , Hunt Linda , Zhang Mengzhu 
Published: March 2022

AbstractLike every other continent in the world, Antarctica has been affected by the COVID-19 pandemic, in an imagined as well as a practical sense. Antarctica is a mediated experience; that is, most of us experience the place through films, novels, music, visual arts and the media. We present an analysis of media articles from eight countries over three time periods - pre-COVID-19 outbreak (October–December 2019), shortly after the pandemic hit the headlines (March–May 2020) and when the virus was established (October–December 2020) - to discover how COVID-19 may have changed Antarctic discourse. Our study shows that representations of Antarctica have been affected by the pandemic, in some instances reinforcing existing ideas and in other cases bringing new ideas to the fore. Based on our findings, we believe that COVID-19 has begun to change representations of Antarctica, stepping us away from the prevailing Antarctic hero narrative and providing a more contemporary understanding of the Antarctic experience. We argue that this may increase our motivation to engage with Antarctic issues, with associated implications for future global stewardship of the region.
Asymptomatic latent Wolff–Parkinson–White syndrome detected during school heart screening: a case Report
Authors: Aoki Hisaaki , Nakamura Yoshihide 
Published: March 2022

AbstractIn latent Wolff–Parkinson–White syndrome, ventricular pre-excitation is inapparent during sinus rhythm but carries the same possibility of sudden cardiac death and palpitations as overt Wolff–Parkinson–White syndrome. It is difficult to diagnose latent Wolff–Parkinson–White syndrome when a patient does not have syncope or palpitations. We report the case of an asymptomatic patient with latent Wolff–Parkinson–White syndrome detected on school heart screening using subtle electrocardiography findings.
Kant on Common Sense and Empirical Concepts
Authors: Sethi Janum 
Published: March 2022

AbstractKant’s notion of common sense (Gemeinsinn) is crucial not only for his account of judgements of beauty, but also for the link he draws between the necessary conditions of such judgements and cognition in general. Contrary to existing interpretations which connect common sense to pleasure, I argue that it should be understood as the capacity to sense the harmony of the cognitive faculties through asui generissensation distinct from pleasure. This sensed harmony of the faculties is not only the ground of judgements of beauty and the basis of pleasure in the beautiful, but is also essential, I argue, for the reflecting judgements through which we acquire empirical concepts.
SET THEORY AND A MODEL OF THE MIND IN PSYCHOLOGY
Authors: TÖRNQUIST ASGER , MAMMEN JENS 
Published: March 2022

AbstractWe investigate the mathematics of a model of the human mind which has been proposed by the psychologist Jens Mammen. Mathematical realizations of this model consists of what the first author (A.T.) has called Mammen spaces, where a Mammen space is a triple
$(U,\mathcal S,\mathcal C)$
, where U is a non-empty set (“the universe”),
$\mathcal S$
is a perfect Hausdorff topology on U, and
$\mathcal C\subseteq \mathcal P(U)$
together with
$\mathcal S$
satisfy certain axioms.We refute a conjecture put forward by Hoffmann-Jørgensen, who conjectured that the existence of a “complete” Mammen space implies the Axiom of Choice, by showing that in the first Cohen model, in which ZF holds but AC fails, there is a complete Mammen space. We obtain this by proving that in the first Cohen model, every perfect topology can be extended to a maximal perfect topology.On the other hand, we also show that if all sets are Lebesgue measurable, or all sets are Baire measurable, then there are no complete Mammen spaces with a countable universe.Further, we investigate two new cardinal invariants
$\mathfrak u_{M}$
and
$\mathfrak u_{T}$
associated with complete Mammen spaces and maximal perfect topologies, and establish some basic inequalities that are provable in ZFC. Then we show
$\mathfrak u_{M}=\mathfrak u_{T}=2^{\aleph _{0}}$
follows from Martin’s Axiom, and, contrastingly, we show that
$\aleph _{1}=\mathfrak u_{M}=\mathfrak u_{T}<2^{\aleph _{0}}=\aleph _{2}$
in the Baumgartner–Laver model.Finally, consequences for psychology are discussed.