bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data Access, Control, and Privacy Protection in the VODAN-Africa Architecture
Authors: Purnama Jati Putu Hadi , van Reisen Mirjam , Flikkenschild Erik , Oladipo Fransisca , Meerman Bert , Plug Ruduan , Nodehi Sara 
Published: August 2022

AbstractThe Virus Outbreak Data Network (VODAN)-Africa aims to contribute to the publication of Findable Accessible, Interoperable, and Reusable (FAIR) health data under well-defined access conditions. The next step in the VODAN-Africa architecture is to locally deploy the Center for Expanded Data Annotation and Retrieval (CEDAR) and arrange accessibility based on the ‘data visiting’ concept. Locally curated and reposited machine-actionable data can be visited by queries or algorithms, provided that the conditions of access are met. The goal is to enable the multiple (re)use of data with secure access functionality by clinicians (patient care), an idea aligned with the FAIR-based Personal Health Train (PHT) concept. The privacy and security requirements in relation to the FAIR Data Host and the FAIRification workspace (to produce metadata) or dashboard (for the patient) must be clear to design the IT architecture. This article describes a (first) practice, a reference implementation in development, within the VODAN-Africa and Leiden University Medical Center community.
Common Hamsters in and Outside the City: Some Reflections on Urban Biodiversity, Species Recovery and the EU Habitats Directive
Authors: Schoukens Hendrik 
Published: August 2022

Abstract
The Wild or Common hamster (Cricetus cricetus) is found across a broad swathe of Eurasia, stretching from Belgium in the West to the Altai Mountains in Russia. Once it was considered a farmland pest. In spite of being a strictly protected species under the EU Habitats Directive since 1994, its populations have continued to plummet throughout the past decades in many Member States such as France, the Netherlands, Belgium and Germany. This paper analyses the recent case law developments regarding this enigmatic rodent, which paradoxically has featured in no less than three rulings of the Court of Justice of the EU throughout the past decades. The two most recent rulings focus on the protected status of this species in a urban context, since one of the largest populations of common hamsters is currently situated in the Austrian capital of Vienna. There the presence of the protected species interfered with future urban development plans, which presented the Court of Justice of the EU with the opportunity to clarify certain key concepts that are entrenched in the system of strict species protection. This paper outlines the primary lessons that can be drawn from the recent jurisprudence and sketches the unlocked potential that is present in the recent judicial decisions for more effective species recovery, in general, and the future of the common hamster, in particular. The main thread throughout this article is the leeway available to better align the survival of protected species with urban development.
Criteria for Identifying Splitting of Projects (Salami-Slicing) Tactic in Light of the C-11/20 Regione Puglia Case and eia Practice in Greece
Authors: Pouikli Kleoniki , Tsakalogianni Ifigeneia 
Published: August 2022

Abstract
The aim of this paper is to assess the method of ‘salami-slicing’ or ‘project splitting’, which refers to the act of splitting of larger projects into smaller units before or during the environmental impact assessment procedure, as provided for in the eia Directive. To this end, emphasis is placed on the definition and key features of this concept as delineated by the Court of Justice of the European Union (cjeu). The debate is enriched by the recent cjeu Regione Puglia case as well as the analysis of the salami-slicing tactic in Greek case-law and public administrative practice. Subsequently, in light of the EU and Greek jurisprudence on this matter, the determination of certain criteria that can be used as rebuttable presumptions of identifying salami-slicing is attempted. Lastly, recognizing that salami-slicing practices go beyond (the scope of) a technical assessment, it is concluded that the emergence of standard salami-slicing criteria might be of added value both in safeguarding the legality of the entirety of the environmental permitting process and in ensuring the effective implementation of the precautionary principle.
cjeu (Case C-629/19: Sappi Austria Produktions-GmbH & Co. kg, Wasserverband ‘Region Gratkorn-Gratwein’ v Landeshauptmann von Steiermark: Suitable Recovery and Recycling Operations Surrounding Sludge in the EU)
Authors: Backes Chris , Kajić Matija 
Published: August 2022

Abstract
Even with extensive case law before the cjeu on the notion of ‘waste’, questions remain around classification of substances as waste and end-of-waste status of certain waste streams. This uncertainty hampers the transition to a circular economy. In the case at hand, a mixture of sludge from paper production and sludge from a municipal wastewater treatment plant was used as fuel for the paper plant. Although the majority (97%) of the mixture came from the paper production process and therefore would be a by-product (and hence not waste), and only 3% of the mixture stemming from the municipal waste water facility qualify waste, the mixture as a whole is assumed to be waste. Whether the ‘end of waste-criteria’ of Article 6(1) Waste Framework Directive can successfully be applied to the case, is up to the national court to decide. In addition, the case is interesting as an affirmation of the ‘Rheinmühlen/Elchinov-doctrine’.
Contribution of Masticatory Muscle Pattern in Craniofacial Morphology: A Systematic Review
Authors: Agrawal Ashish , Nandini Aishwarya , Das Manami 
Published: August 2022

Context: The objective of this systematic review is to analyze the pattern of masticatory muscle and its effects on craniofacial structures. Method: Electronic search was conducted for relevant studies in last 20 years (from January 1, 2002 to December 31, 2021) on the following databases: PubMed, Google scholar, Web of Science, Cochrane Library, and Wiley Library database. Hand searching of selected orthodontic journals was also undertaken. The selected studies were assessed for the risk of bias in Cochrane collaboration risk of bias tool. The “traffic plot” and “weighted plot” risk of bias distribution are designed in the RoB 2 tool. Two authors extracted the data which was then analyzed by another reviewer to obtain the final data. Results: Six studies fulfilled inclusion criteria. The risk of bias was high for all the studies. The sample size of the studies, methodologies used, muscles under study, parameters of muscles, and statistical analysis performed were extracted. The methodologies and results of the studies were found to be heterogenous. Conclusions: It is found that the vertical craniofacial dimensions can be better appreciated by masseter than by medial pterygoid. The volume of masseter is superior predictor than its cross-sectional area. The volume of the medial pterygoid affects the ramus of the mandible and the length and width of the lateral pterygoid are significantly correlated with transverse skeletal dimensions.
Impact of mesenchymal stromal cell–derived vesicular cargo on B-cell acute lymphoblastic leukemia progression
Authors: Karantanou Christina , Minciacchi Valentina R. , Kumar Rahul , Zanetti Costanza , Bravo Jimena , Pereira Raquel S. , Tascher Georg , Tertel Tobias , Covarrubias-Pinto Adriana , Bankov Katrin , Pfeffermann Lisa-Marie , Bonig Halvard , Divieti-Pajevic Paola , McEwan David G. , Giebel Bernd , Münch Christian , Dikic Ivan , Krause Daniela S. 
Published: August 2022

Abstract
Leukemia cells reciprocally interact with their surrounding bone marrow microenvironment (BMM), rendering it hospitable to leukemia cell survival, for instance through the release of small extracellular vesicles (sEVs). In contrast, we show here that BMM deficiency of pleckstrin homology domain family M member 1 (PLEKHM1), which serves as a hub between fusion and secretion of intracellular vesicles and is important for vesicular secretion in osteoclasts, accelerates murine BCR-ABL1+ B-cell acute lymphoblastic leukemia (B-ALL) via regulation of the cargo of sEVs released by BMM-derived mesenchymal stromal cells (MSCs). PLEKHM1-deficient MSCs and their sEVs carry increased amounts of syntenin and syndecan-1, resulting in a more immature B-cell phenotype and an increased number/function of leukemia-initiating cells (LICs) via focal adhesion kinase and AKT signaling in B-ALL cells. Ex vivo pretreatment of LICs with sEVs derived from PLEKHM1-deficient MSCs led to a strong trend toward acceleration of murine and human BCR-ABL1+ B-ALL. In turn, inflammatory mediators such as recombinant or B-ALL cell–derived tumor necrosis factor α or interleukin-1β condition murine and human MSCs in vitro, decreasing PLEKHM1, while increasing syntenin and syndecan-1 in MSCs, thereby perpetuating the sEV-associated circuit. Consistently, human trephine biopsies of patients with B-ALL showed a reduced percentage of PLEKHM1+ MSCs. In summary, our data reveal an important role of BMM-derived sEVs for driving specifically BCR-ABL1+ B-ALL, possibly contributing to its worse prognosis compared with BCR-ABL1− B-ALL, and suggest that secretion of inflammatory cytokines by cancer cells in general may similarly modulate the tumor microenvironment.
Preconception mental health and the relationship between antenatal depression or anxiety and gestational diabetes mellitus: a population-based cohort study
Authors: Thiele Grace A. , Ryan Deirdre M. , Oberlander Tim F. , Hanley Gillian E. 
Published: August 2022

Abstract
Background
Antenatal depression and anxiety are highly prevalent conditions that have been associated with increased risk for myriad adverse outcomes. Current literature exploring the connection between antenatal mental health and gestational diabetes mellitus (GDM) is limited, presenting conflicting evidence. We sought to evaluate the association between antenatal depression/anxiety (DEP-ANX) and GDM using population-based, administrative data, accounting for aspects of preconception mental health.

Methods
In this population-based retrospective cohort study, we included all singleton births in British Columbia, Canada from April 1, 2000, to December 31, 2014. We identified instances of DEP-ANX from outpatient and inpatient records that included relevant diagnostic codes and stratified our cohort by preconception DEP-ANX persistence. Logistic regression models were run to estimate odds of GDM given antenatal DEP-ANX. Models were adjusted for the birthing person’s socio-demographics and pregnancy characteristics. Using an expanded cohort, we ran conditional logistic regression models that matched birthing people to themselves (in a subsequent pregnancy) based on discordance of exposure and outcome.

Results
Out of the 228,144 births included in this study, 43,664 (19.1%) were to birthing people with antenatal health service use for DEP-ANX. There were 4,180 (9.6%) cases of GDM among those antenatal exposure to DEP-ANX compared to 15,102 (8.2%) among those without exposure (SMD 0.049). We observed an unadjusted odds ratio (OR) of 1.19 (95% CI: 1.15 – 1.23) and fully adjusted OR of 1.15 (95% CI: 1.11 – 1.19) overall. Apparent risk for GDM given antenatal DEP-ANX was highest among the no DEP-ANX history stratum, with a fully adjusted OR of 1.24 (95% CI: 1.15 – 1.34). Associations estimated by matched sibling analysis were non-significant (fully adjusted OR 1.19 [95% CI: 0.86 – 1.63]).

Conclusions
Results from this population-based study suggest an association between antenatal DEP-ANX and GDM that varied based on mental health history. Our analysis could suggest that incident cases of DEP-ANX within pregnancy are more closely associated with GDM compared to recurring or chronic cases.
Does nail size or difference between canal and nail diameter influence likelihood of union or time to union of femoral shaft fractures treated with intramedullary nailing? A retrospective cohort study
Authors: Shih Chiu-Yu , Kor Chew-Teng , Hsieh Cheng-Pu , Chen Chiu-Liang , Lo Yu-Cheng 
Published: August 2022

Abstract
Background
This study aims to determine whether nail size or the difference between canal and nail diameter (CN difference) affects the union rate and time of femoral shaft fracture treated with an interlocking intramedullary nail (IMN).

Methods
This was a retrospective review of 257 patients with femoral shaft fractures treated with IMN at a tertiary trauma medical center. All the IMN inserted were the same (Stryker T2 Femoral Nail). The patients were divided into groups based on nail size (10-, 11-, 12-, or 13-mm) and CN difference (< 1, 1–2, or > 2 mm), and union rate and time to union were compared.

Results
The 10-, 11-, 12-, and 13-mm groups based on nail size had 113, 74, 54, and 16 patients, respectively. The overall union rate was 97% (257/265). No significant differences in union rate or time to union were observed among these 4 groups. The groups based on CN differences of < 1-, 1 to 2, and > 2 mm comprised 143, 79, and 35 patients, respectively. Again, no significant differences were noted in union rate or mean time to union among the groups.

Conclusions
Similar union rate and time to union were observed, regardless of nail size or CN difference. This finding indicates that most simple femoral shaft fractures can be treated with a standard, reamed 10-mm IMN. A larger nail insertion is unnecessary and presents more risks; comparatively, the use of a small nail with less reaming is simpler, requires shorter operative times, results in less blood loss, and is less expensive.
Factors that influence breast cancer screening among women of reproductive age in the Nandom Municipality, Ghana
Authors: Wuur Margaret Mary , Duodu Dillys Adomakoa , Tarkang Elvis Enowbeyang 
Published: August 2022

Abstract
Background
In Ghana, breast cancer is a major public health concern and the most common type of cancer among women in terms of mortality and incidence. This study determined the factors influencing breast cancer screening among women of reproductive age in Nandom Municipality, Ghana using the Health Belief Model as the conceptual model.

Methods
The study was cross-sectional in design. A pretested structured questionnaire was administered to 243 womens of reproductive age in the Nandom Municipality. Descriptive and inferential statistics were performed using STATA version 16 at a 0.05 level of significance.

Results
The uptake of breast cancer screening was 51.9%. Respondents who had a tertiary level of education were less likely to be screened for breast cancer [AOR = 0.10 (95% CI = 0.02–0.54); p = 0.008]. Respondents who perceived high susceptibility to breast cancer were more likely to get screened [AOR = 1.97 (95% CI = 1.12–3.47), p = 0.019]. Respondents who perceived the high severity of breast cancer were more likely to be screened for breast cancer [AOR = 4.55 (95% CI = 1.32–15.76), p = 0.017]. Also, respondents who perceived high barriers to breast cancer screening were more likely to be screened for breast cancer [AOR = 0.15(95% CI = 1.42–4.22), p < 0.001].

Conclusion
The uptake of screening among women of reproductive age in the Nandom Municipality is low. Health promotion interventions to improve breast cancer screening should target women with a tertiary level of education and should focus on heightening the perceived threat of breast cancer and minimizing barriers to breast cancer screening.
The short-term effect of a myofascial protocol versus light touch applied to the cervical spine towards the prevention of balance disorders in the elderly: protocol of a randomised controlled trial
Authors: Pinloche Laurianne , Souvignet Solène , Germain Michèle , Monteil Karine , Hautier Christophe 
Published: August 2022

Abstract
Background
Falling is a major trauma that can occur with aging, leading to very significant psychological and physical health effects with financial and societal consequences. It is therefore essential to explore therapeutic treatments that can reduce this risk. Some recognized effective treatments exist, concerning in particular the re-education of the muscles of the lower limbs. However, to our knowledge, none of them focus on the cervical spine although the latter is located at an essential physiological crossroads. Manual therapy, which has already demonstrated its impact on pain and balance parameters in the elderly, could be a painless and non-invasive tool of choice in addressing this problem.

Methods
Interventional study (not related to a health product), monocentric, prospective, controlled, randomized double-blind (patient and evaluator performing the measurements). The experiment will take place over three measurement periods on D0, D7 and D21. On D0 subjects will be randomized in 2 groups: experimental and placebo group. Both groups will be assessed on: Short Physical Performance Battery test score, walking speed, lower limb strength, balance, heart rate variability and cervical spine strength and mobility. Then the experimental group will receive a myofascial release protocol applied to the cervical spine and the placebo group will receive a placebo light touch protocol. The intervention will be followed by the same measurements as before. This schedule will be reproduced on D7. On D21, only one assessment will be done.

Discussion
This study started in 2020 but could not go beyond the inclusion phase due to the COVID pandemic. It is envisaged that recruitment could resume during 2022.
Trial registration: Registered by the Comité de Protection des Personnes—Sud Méditerranée; under the title “Prévention des troubles de l’équilibre chez le senior: influence de la thérapie manuelle appliquée au rachis sur les paramètres statiques et dynamiques», n° 19.12.27.47.259 in date of February 4, 2020.
Registered by ClinicalTrials.gov ID: NCT05475652; under the title « The Influence of Manual Therapy Applied to the Cervical Spine in the Prevention of Balance Disorders in the Elderly (ManEq)”.
Respect for illiterate or unconscious patient’s autonomy as a requirement for the legality of medical procedures in the polish healthcare system: a case report and review of the literature
Authors: Kocańda K. , Głuszek S. , Szerla M. K. , Domagała M. 
Published: August 2022

AbstractAccording to the Polish law, each patient has the right to refuse to consent to a medical procedure, even if the refusal concerns a life-saving procedure. It may be difficult for a physician to accept this kind of decision. In each case, however, medical intervention requires patient’s consent. Its lack makes physician’s actions illegal. Such a situation becomes more complicated when the patient who is intellectually incompetent, unconscious or illiterate is unable to express a consent to a medical procedure. Then, the possibility and the need to document and prove the patient’s consent becomes crucial from the point of view of the legality of medical personnel’s conduct. In this article, two representative clinical cases are discussed in the context of the legal assessment of the physician’s conduct in the event of legal complications related to the process of consenting to medical treatment. The authors analyze ethical dilemmas and legal risks that doctors may face in the process of consenting to risky medical procedures by unconscious and illiterate patient.
Direct and indirect savings from parallel imports in Sweden
Authors: Granlund David 
Published: August 2022

AbstractBackgroundThe aim was: i) to quantify the direct and indirect savings from parallel imports in Sweden during a period when sellers were forbidden from giving discounts to pharmacies, and ii) to study if the effects of competition from parallel imports on list prices became smaller in absolute size when sellers were allowed to give discounts to pharmacies.MethodsWe analyzed the monthly prices for 3068 products during 61 months when discounts were forbidden and for 2504 products during 84 months when discounts were allowed. The price effects were estimated using dynamic models that rendered lagged numbers of competitors into valid and strong instruments for the current values.ResultsWhen discounts were forbidden, parallel imports had a market share of 16% and were on average 9% cheaper than locally sourced drugs, which yielded a direct saving of 231 million Swedish kronor (SEK) (24 million EUR) per year. Also, parallel imports reduced the prices of products with the same substance by, on average, 6% in the long-term, which yielded indirect savings of 421 million SEK (44 million EUR) per year. In total, parallel imports reduced the cost for on-patent pharmaceuticals by 4%. When discounts were allowed, the average gap in list price between parallel imports and locally sourced products was reduced to 0.8%, and the list prices of locally sourced products were no longer significantly affected by competition from parallel imports.ConclusionWhen discounts were allowed, the savings of parallel imports through lower list prices were replaced by savings of pharmacies through secret discounts.
Predicting the cost of COVID-19 treatment and its drivers in Indonesia: analysis of claims data of COVID-19 in 2020-2021
Authors: Nugraha Ryan R. , Pratiwi Mutia A. , Al-Faizin Ruli Endepe , Permana Ardian Budi , Setiawan Ery , Farianty Yuli , Komaryani Kalsum , Thabrany Hasbullah 
Published: August 2022

Abstract
Background
Recent Coronavirus Disease-19 (COVID-19) pandemic shows that health system, particularly hospital care, takes the highest toll on COVID-19. As hospital gets to manage the surge of COVID-19 cases, it is important to standardize treatment standard and package for COVID-19. Until recently, in Indonesia, COVID-19 curative package in hospital is paid using a retrospective payment system (claims system) using a per-diem rate. Quantifying standard cost using an established retrospective claims dataset is important as a basis for standard formulation for COVID-19 package treatment, should COVID-19 be accommodated into the benefit package for Universal Health Coverage (UHC) under the National Health Insurance.

Methods
We estimated a standard cost for COVID-19 treatment using provider’s perspective. The analysis was conducted retrospectively using established national COVID-19 claims dataset during January 2020 until 2021. Utilizing individual-or-patient level analysis, claims profile were broken down per-patient, yielding descriptive clinical and care-related profile. Estimate of price and charge were measured in average. Moreover, indicators were regressed to the total charged price (in logarithmic scale) so as to find the predictors of cost.

Results
Based on the analysis of 102,065 total claims data received by MOH in 2020-2021, there is an average claim payment for COVID-19 in the amount of IDR 74,52 million (USD$ 5175). Significant difference exists in hospital tariffs or price to the existing claims data, indicating profit for hospital within its role in managing COVID-19 cases. Claim amount predictors were found to be associated with change of claim amount, including high level of severity, hospital class, intensive care room occupancy and ventilator usage, as well as mortality.

Conclusion
As COVID-19 pandemic shifts towards an endemic, countries including Indonesia need to reflect on the existing payment system and move towards a more sustainable payment mechanism for COVID-19. The COVID-19 payment system needs to be integrated into the existing national health insurance allowing bundled payment to become more sustainable, which can be achieved by comprehensively formulating the bundled payment package for COVID-19.