bluuebunny/crossref_metadata_2025_split huggingface dataset:
La institucionalización académica de la Didáctica General en España
Authors: Heredia Manrique Alfonso 
Published: July 2022

The aim of this study is to show the path that General Didactics followed for its institutionalization as an academic discipline in the syllabus of teacher education in Spain, since it appeared in 1898 until the 1960s. The empirical framework is based on historical research: on the one hand, we reviewed the study programs of the School of Higher Education for Teaching, the Schools of Teaching and the Pedagogy Section of the Faculty of Philosophy and Letters from the Central University of Madrid, during the period studied to detect the presence of General Didactics. On the other hand, we consulted the legal provisions on the administrative development of the first Didactics chair in Spain, from when it was projected until it was occupied, after a long journey that lasted more than eight years. The most outstanding results are that this academic discipline, representative of a whole wide area of pedagogical knowledge, is not present in the School of Higher Education for Teaching, due to its difficulties for its institutional recognition in Teaching Schools. However, it is present from the beginning in the Section of Pedagogy, where it is institutionally consolidated with the endowment of the Didactics chair. The conclusion reached is that the main hurdle for General Didactics to become an autonomous pedagogical field of knowledge sits at the fact that the trajectory of the academic institutionalization of General Didactics is temporarily expensive and epistemologically difficult because of denomination problems
Este estudio tiene como objetivo mostrar la trayectoria de la institucionalización de la Didáctica General como disciplina académica, desde que aparece como tal en 1898 hasta los años sesenta del siglo veinte. La metodología utilizada ha consistido en indagar tres vías por las cuales se atisba claramente dicho proceso. Las dos primeras comprobando su presencia como asignatura en los planes de estudio de las Escuelas de Magisterio y de la Sección de Pedagogía de la Facultad de Filosofía y Letras de la Universidad de Madrid, durante el periodo estudiado. Y la tercera vía, más de consolidación, haciendo el seguimiento oficial de la primera cátedra de Didáctica en España, desde que se dota hasta que se cubre, tras un largo recorrido que duró más de ocho años. Como resultado al que se llega se observa el dificultoso camino que sigue esa institucionalización; por un lado para mantenerse presente como asignatura en algunos planes de estudio; y por otro, dado el entorpecimiento siempre presente, por cuestiones epistemológicas de denominación. Actualmente existe mucho interés investigador sobre disciplinas, por eso sorprende ver la escasez de estudios en relación a la Didáctica General cuando fue parte sustancial en el surgimiento de la Pedagogía.
La educación social en la escuela: una revisión actualizada
Authors: Díez Gutiérrez Enrique Javier , Muñiz-Cortijo Lucía-María 
Published: July 2022

This review article tries to answer the question of whether there is the need to incorporate social education professionals into the educational system, as has already been done in some Autonomous Communities in Spain. For this purpose, a systematic review of the literature (SLR) of 56 articles published in open access, from January 2000 to August 2020, has been carried out in the databases: Scopus, Dialnet, Web of Science, Redalyc and Scielo. The validation was based on the extended criteria of the University of York. The findings reflect that, in a changing society, where the interaction of the school with its social environment is increasingly decisive in the development and training of students, the role of social education professionals is essential from the approach of inclusive and comprehensive education in the educational system. The conclusions and discussion show that their role and tasks are fundamental and that, following the recent Organic Law for the comprehensive protection of children and adolescents against violence, which incorporates the figure of the welfare and protection coordinator in schools, it would be necessary to integrate the role of these professionals in all schools by means of this figure.
En este artículo de revisión se trata de responder a la pregunta sobre la necesidad de incorporar a todo el sistema educativo a los profesionales de la educación social, tal como ya se ha realizado en algunas Comunidades Autónomas en España. Para ello se ha realizado una revisión sistemática de la literatura (SLR) de 56 artículos publicados en acceso abierto, de enero de 2000 a agosto de 2020, en las bases de datos: Scopus, Dialnet, Web of Science, Redalyc y Scielo. La validación se dio con los criterios ampliados de la Universidad de York. Los hallazgos reflejan que, en una sociedad cambiante, donde la interacción de la escuela con su entorno social es cada vez más determinante en el desarrollo y formación del alumnado, el papel de los profesionales de la educación social se hace imprescindible desde un planteamiento de educación inclusiva e integral en el sistema educativo. Las conclusiones y discusión reflejan que su función y tareas son actualmente necesarias y que la reciente Ley Orgánica de protección integral a la infancia y la adolescencia frente a la violencia, que incorpora la figura del coordinador o coordinadora de bienestar y protección en los centros educativos, sería una necesidad integrar el papel de estos profesionales en todos los centros escolares a través de esta figura.
The Cultural Embedding of Foreknowledge in Modern Society
Authors: Daye Christian 
Published: July 2022

Review essay of:
Andersson, Jenny. The Future of the World: Futurology, Futurists, and the Struggle for the Post-Cold War Imagination. Oxford, New York: Oxford University Press, 2018.
Pietruska, Jamie L. Looking Forward: Prediction & Uncertainty in Modern America. Chicago: University of Chicago Press, 2018.
Pinch Strength Measurements in Adolescents With Pediatric Multiple Sclerosis
Authors: Squillace Mary , Krupp Lauren , Ray Sharon , Muratori Lisa M. 
Published: July 2022

ABSTRACT

BACKGROUND
Multiple sclerosis (MS) is a degenerative disease with typical onset between 20 and 50 years of age. An increase in MS cases has been found in the adolescent US population. Adolescents require fine motor manipulation skills for their functional and academic performance. Deficits in the major components of manipulation skills may result in insufficient function. This study examined the 2-point, 3-point, and lateral pinch strength of adolescents diagnosed as having MS.

METHODS
Seventy-four adolescents, 37 with a diagnosis of relapsing-remitting MS and a control group of 37 age-matched peers, participated in this study. Data on 2-point, 3-point, and lateral pinch strength in both hands were collected using a pinch meter. Analyses of covariance were used to describe differences across the 2 groups, and effect sizes (Cohen d) were calculated by finding the mean difference between the study groups divided by the pooled SD.

RESULTS
A significant difference was found in the 2-point pinch strength of the right hand of participants with pediatric MS compared with age- and sex-matched control participants. There were no significant differences in 2-point pinch strength of the left hand or in 3-point or lateral pinch strength of the right and left hands.

CONCLUSIONS
Pinch grasp strength was differentially affected in adolescents with MS. Pinch strength should be assessed and considered in adolescents with MS for a better understanding of their functional performance of fine motor tasks in activities of daily living and academics.
Genomic landscape of lymphatic malformations: a case series and response to the PI3Kα inhibitor alpelisib in an N-of-1 clinical trial
Authors: Shaheen Montaser F , Tse Julie Y , Sokol Ethan S , Masterson Margaret , Bansal Pranshu , Rabinowitz Ian , Tarleton Christy A , Dobroff Andrey S , Smith Tracey L , Bocklage Thèrése J , Mannakee Brian K , Gutenkunst Ryan N , Bischoff Joyce , Ness Scott A , Riedlinger Gregory M , Groisberg Roman , Pasqualini Renata , Ganesan Shridar , Arap Wadih 
Published: July 2022

Background:Lymphatic malformations (LMs) often pose treatment challenges due to a large size or a critical location that could lead to disfigurement, and there are no standardized treatment approaches for either refractory or unresectable cases.Methods:We examined the genomic landscape of a patient cohort of LMs (n = 30 cases) that underwent comprehensive genomic profiling using a large-panel next-generation sequencing assay. Immunohistochemical analyses were completed in parallel.Results:These LMs had low mutational burden with hotspot PIK3CA mutations (n = 20) and NRAS (n = 5) mutations being most frequent, and mutually exclusive. All LM cases with Kaposi sarcoma-like (kaposiform) histology had NRAS mutations. One index patient presented with subacute abdominal pain and was diagnosed with a large retroperitoneal LM harboring a somatic PIK3CA gain-of-function mutation (H1047R). The patient achieved a rapid and durable radiologic complete response, as defined in RECIST1.1, to the PI3Kα inhibitor alpelisib within the context of a personalized N-of-1 clinical trial (NCT03941782). In translational correlative studies, canonical PI3Kα pathway activation was confirmed by immunohistochemistry and human LM-derived lymphatic endothelial cells carrying an allele with an activating mutation at the same locus were sensitive to alpelisib treatment in vitro, which was demonstrated by a concentration-dependent drop in measurable impedance, an assessment of cell status.Conclusions:Our findings establish that LM patients with conventional or kaposiform histology have distinct, yet targetable, driver mutations.Funding:R.P. and W.A. are supported by awards from the Levy-Longenbaugh Fund. S.G. is supported by awards from the Hugs for Brady Foundation. This work has been funded in part by the NCI Cancer Center Support Grants (CCSG; P30) to the University of Arizona Cancer Center (CA023074), the University of New Mexico Comprehensive Cancer Center (CA118100), and the Rutgers Cancer Institute of New Jersey (CA072720). B.K.M. was supported by National Science Foundation via Graduate Research Fellowship DGE-1143953.Clinical trial number:NCT03941782
G6PD and HBB polymorphisms in the Senegalese population: prevalence, correlation with clinical malaria
Authors: Thiam Fatou , Diop Gora , Coulonges Cedric , Derbois Céline , Mbengue Babacar , Thiam Alassane , Nguer Cheikh Momar , Zagury Jean Francois , Deleuze Jean-Francois , Dieye Alioune 
Published: July 2022

Background
Host genetic factors contribute to the variability of malaria phenotypes and can allow a better understanding of mechanisms involved in susceptibility and/or resistance to Plasmodium falciparum infection outcomes. Several genetic polymorphisms were reported to be prevalent among populations living in tropical malaria-endemic regions and induce protection against malaria. The present study aims to investigate the prevalence of HBB (chr11) and G6PD (chrX) deficiencies polymorphisms among Senegalese populations and their associations with the risk for severe Plasmodium falciparum malaria occurrence.

Methods
We performed a retrospective study with 437 samples, 323 patients recruited in hospitals located in three different endemic areas where malaria episodes were confirmed and 114 free malaria controls. The patients enrolled were classified into two groups: severe malaria (SM) (153 patients) and uncomplicated malaria (UM) (170 patients). PCR and DNA sequencing assessed host genetic polymorphisms in HBB and G6PD. Using a multivariate regression and additive model, estimates of the impact of human HBB and G6PD polymorphisms on malaria incidence were performed.

Results
Six frequent SNPs with minor allele frequencies (MAF) > 3% were detected in the HBB gene (rs7946748, rs7480526, rs10768683, rs35209591, HbS (rs334) and rs713040) and two in the G6PD gene (rs762515 and rs1050828 (G6PD-202 G > A). Analysis of selected HbS polymorphism showed significant association with protective effect against severe malaria with a significant p-value = 0.033 (OR 0.38, 95% CI [0.16–0.91]) for SM vs. UM comparison. Surprisingly, our study did not identify the protective effect of variant HbC polymorphism against severe malaria. Finally, we found some of the polymorphisms, like HbS (rs334), are associated with age and biological parameters like eosinophils, basophils, lymphocytes etc.

Conclusion
Our data report HBB and G6PD polymorphisms in the Senegalese population and their correlation with severe/mild malaria and outcome. The G6PD and HBB deficiencies are widespread in West Africa endemic malaria regions such as The Gambia, Mali, and Burkina Faso. The study shows the critical role of genetic factors in malaria outcomes. Indeed, genetic markers could be good tools for malaria endemicity prognosis.
The roles of trait and process resilience in relation of BIS/BAS and depressive symptoms among adolescents
Authors: Masuyama Akihiro , Kubo Takahiro , Shinkawa Hiroki , Sugawara Daichi 
Published: July 2022

Background
Extensive literature revealed the relations of depression with behavioral inhibition system (BIS) and behavioral activation system (BAS) as vulnerability and with resilience separately. Besides, the concept of resilience is still broad and ambiguous. Thus, this study aimed to reveal the mediation of two aspects of resilience: trait and process, in the relations of BIS and BAS to depression among adolescents.

Methods
The data set used in this study was a cross-sectional survey among 965 adolescents. The obtained data from the self-reported questionnaires used in this study were as below: Depression Serf-Rating Scale for Children (DSRS-C), Behavioral Inhibition and Behavioral Activation System Scale (BIS/BASS), and Bidimensional Resilience Scale (BRS). Structural equation modeling (SEM) was conducted to verify the hypothesized relations among BIS/BAS, trait and behavior resilience, and depressive symptoms.

Results
The obtained indices of fit from SEM were good or sufficient (χ2 = 562.911, df = 96, p < 0.001; CFI = 0.925; NFI = 0.913; RMSEA = 0.073, 90% CI [0.067, 0.079]; SRMR = 0.066). And the modeling showed that both BIS/BAS directly and indirectly influenced to depression. The indirect effects of BIS/BAS were mediated only trait resilience except the indirect effect of BIS via behavioral resilience.

Discussion
Our results suggested that trait resilience played a significant mediation role in the relationships between BIS/BAS and depression. Trait but not process resilience could be considered suitable as an intervention target in line with decreasing depression.
Toxic Masculinities in Post-9/11 Islam-Themed French Novels: Plateforme and Syngué Sabour. Pierre de Patience
Authors: Udasmoro Wening 
Published: July 2022

ABSTRACT
This article aims to explore the concept of toxic masculinities in two French literary works, namely Plateforme by Michel Houellebecq and Syngué Sabour. Pierre de Patience by Atiq Rahimi, whose stories are related to Islam after the September 11, 2001 tragedy. Toxic masculinities are suspected to be present in both works, namely by placing women in the position of objects of sexual gaze and symbolic violence. This article dredges the concept of toxic masculinities, which is a derivation of the concept of hegemonic masculinities introduced by Raewyn Connell. This paper employs a critical discourse analysis method by examining the language used by the authors at levels of linguistic practice, discursive practice, and social practice with corpus data taken from the wordings and rewordings of the texts. This paper concludes that sexual gaze and symbolic violence are toxic because they can be drivers of physical violence.
Keywords: toxic, masculinities, French literature, Islam
Bioengineering Extracellular Vesicles for the Treatment of Cardiovascular Diseases
Authors: Ramasubramanian Lalithasri , Du Shixian , Gidda Siraj , Bahatyrevich Nataliya , Hao Dake , Kumar Priyadarsini , Wang Aijun 
Published: July 2022

AbstractCardiovascular diseases (CVD) remain one of the leading causes of mortality worldwide. Despite recent advances in diagnosis and interventions, there is still a crucial need for new multifaceted therapeutics that can address the complicated pathophysiological mechanisms driving CVD. Extracellular vesicles (EVs) are nanovesicles that are secreted by all types of cells to transport molecular cargo and regulate intracellular communication. EVs represent a growing field of nanotheranostics that can be leveraged as diagnostic biomarkers for the early detection of CVD and as targeted drug delivery vesicles to promote cardiovascular repair and recovery. Though a promising tool for CVD therapy, the clinical application of EVs is limited by the inherent challenges in EV isolation, standardization, and delivery. Hence, this review will present the therapeutic potential of EVs and introduce bioengineering strategies that augment their natural functions in CVD.
Mechanical Manipulation of Archimedean Spirals of an Achiral Pyrazinacene for Chiral Assemblies
Authors: Mondal Pramita , Manna Gouranga , Kamilya Tapas , Das Mrinmay , Ariga Katsuhiko , Richards Gary J. , Hill Jonathan P. , Acharya Somobrata 
Published: July 2022

AbstractThe fabrication of chiral assemblies from achiral molecules has attracted considerable interest since it provides insight into the structures of biological systems. It is also of general importance from the point‐of‐view of the various factors affecting self‐assembly processes especially supramolecular chirality. Here, the dynamic interfacial assembly strategy is used to obtain unusual chiral assemblies from achiral linear nitrogen‐rich acene derivatives, the pyrazinacenes. 1D supramolecular J‐aggregate tapes of homogeneous width are coiled to form Archimedean spirals. Moreover, the dynamic assembly process further permits the controlled transformation of the Archimedean spirals into tightly coiled toroids and chiral concentric vortices. Grazing incidence X‐ray diffraction study using synchrotron radiation reveals that J‐aggregate monolayer deposited using the layer‐by‐layer technique forms a lamellar columnar oblique mesophase‐like structure. Molecular packing in J‐aggregates provides a significant channel for the occurrence of charge transport exhibiting carrier mobility of 0.045 cm2 V−1 s−1 due to enhanced electronic coupling. This study illustrates an intriguing approach for achieving chiral supramolecular assemblies from achiral molecules and also reveals the potential of the pyrazinacenes as charge transport materials for molecular electronics.
Single‐Step Wet‐Process Formation of Dual‐Layer Superslippery Coating with Transparency and Robust Omniphobicity
Authors: Tenjimbayashi Mizuki , Hayase Gen , Hiroi Takashi , Ueki Takeshi 
Published: July 2022

AbstractRobust coatings that fully repel liquids have a broad range of applications. However, it remains challenging to have an easy, scalable, and substrate‐independent preparation method for these coatings. Here, a coating solution that forms stable lubricant surface‐to‐solid substrates simply by casting, dipping, or spraying without specific limitation in the substrate, is synthesized. Moreover, the coating is formed inside the long narrow tube by flowing the solution. The solution constitutes nanoparticles, a silicone binder, and a binary mixture of a lubricant and a suitable solvent. The coating is transparent (>90%), self‐healable, mechanically robust, and repels immiscible liquid droplets, including water, oil, solvent, and fluorinated polymers, with negligible sliding angle. The coating comprises two layers: a lubricant stabilizing base layer and a top lubricant layer. Generally, two‐step coating processes require two layers; however, the coating solution solely forms the two layers by the interplay between a solvent evaporation triggered surface lubrication and the interfacial clogging of nanoparticles. This straightforward and universal coating approach for robust omniphobic surface preparation is widely applicable for applications.
Room‐Temperature Printing of Ultrathin Quasi‐2D GaN Semiconductor via Liquid Metal Gallium Surface Confined Nitridation Reaction
Authors: Li Qian , Du Bang‐Deng , Gao Jian‐Ye , Xing Bao‐Yu , Wang Dian‐Kai , Ye Ji‐Fei , Liu Jing 
Published: July 2022

AbstractOutstanding wide‐bandgap semiconductor material such as gallium nitride (GaN) has been extensively utilized in power electronics, radiofrequency amplifiers, and harsh environment devices. Due to its quantum confinement effect in enabling desired deep‐ultraviolet emission, excitonic impact, and electronic transport features, 2D or ultrathin quasi‐2D GaN semiconductors have been one of the most remarkable candidates for future growth of microelectronic devices. Here, for the first time, the authors report a large area, wide bandgap, and room‐temperature quasi‐2D GaN synthesis and printing strategy through introducing the plasma medicated liquid metal gallium surface‐confined nitridation reaction mechanism. The developed direct fabrication and compositional process is consistent with various electronics manufacturing approaches and thus opens an easy going way for cost‐effective growth of the third‐generation semiconductor. In particular, the fully printed field‐effect transistors relying on the GaN thus made show p‐type switching with an on/off ratio greater than 105, maximum field‐effect hole mobility of 53 cm2 V−1 s−1, and a small sub‐threshold swing. As demonstrated, the present method allows to produce at room temperature the GaN with thickness spanning from 1 nanometer to nanometers. This basic method can be further extended, generalized, and utilized for making various electronic and photoelectronic devices in the coming time.
Sterilization of Drug‐Resistant Influenza Virus through Genetic Interference Inspired by Unnatural Amino Acid‐Engineered Particles
Authors: Wu Xuesheng , Zheng Zhetao , Chen Hongmin , Lin Haishuang , Yang Yuelin , Bai Yachao , Xia Qing 
Published: July 2022

AbstractThe frequent emergence of drug resistance during the treatment of influenza A virus (IAV) infections highlights a need for effective antiviral countermeasures. Here, this work presents an antiviral method that utilizes unnatural amino acid‐engineered drug‐resistant (UAA‐DR) virus generated through genetic code expansion to combat emerging drug‐resistant viruses through genomic segment reassortment to produce sterilized progenies due to artificial amber codons in the viral genome. This work validates in vitro that UAA‐DR can provide a broad‐spectrum antiviral strategy for several H1N1 strains, different DR‐IAV strains, multidrug‐resistant (MDR) strains, and even antigenically distant influenza strains (e.g., H3N2). Moreover, a minimum dose of neuraminidase (NA) inhibitors for influenza virus can further enhance the sterilizing effect when combating inhibitor‐resistant strains, partly due to the promoted superinfection of unnatural amino acid‐modified virus in cellular and animal models. The fact that the antiviral effect of UAA‐DR virus cannot be attributed to interferon stimulation and interferon stimulating genes is also investigated. It is anticipated that UAA‐engineered virus‐like particle can be extended to combat emerging drug‐resistant influenza virus and other segmented RNA viruses.