bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potensi Energi Listrik dari Microbial Fuel Cell (MFC) Menggunakan Substrat Molase dan Bakteri Pseudomonas sp.
Authors: Wahyuni Ilmi , Heriyono Heri , Aisyah Aisyah , Baharuddin Maswati , Patunrengi Iswadi Ibrahim 
Published: June 2022

Sugarcane molasses have been reported as potential biomass to produce electricity from its metabolic processes through the microbial fuel cell (MFC) system. However, it is important to improve electrical generation by using both appropriate and readily available substrates and microorganisms. This study aimed to determine the current and potential difference as well as the power density generated from the metabolic process of the molasses substrate. A dual-chamber of MFC was arranged in series to generate electrical current. The anode chamber contained a mixture of molasses substrate, potassium phosphate buffer pH 7, and Pseudomonas sp. The cathode chamber contained 0.2 M KMnO4 electrolyte solution. Measurement of current and potential differences was conducted every 4 hours for 36 hours. The results showed that the maximum current, potential difference, and power density were 1656 mV, 1582 µA, and 1794.37 mW/m2, respectively.Keywords: dual chamber, microbial fuel cell, molasses, Pseudomonas sp. Molase telah banyak dilaporkan sebagai salah satu sumber energi listrik yang potensial dengan menggunakan sistem microbial fuel cell (MFC). Namun demikian, produksi energi listriknya perlu ditingkatkan dengan menggunakan substrat dan mikroorganisme yang tepat dan mudah diperoleh. Tujuan dari penelitian ini adalah untuk mengetahui arus dan beda potensial serta nilai kerapatan daya yang dihasilkan dari proses metabolisme substrat molase menggunakan bakteri Pseudomonas sp. Penelitian ini menggunakan sistem MFC kompartemen ganda sebanyak dua sel yang dirangkai seri. Ruang anoda berisi campuran substrat molase, buffer kalium fosfat pH 7 dan bakteri Pseudomonas sp. Adapun ruang katoda berisi larutan elektrolit KMnO4 0,2 M. Pengukuran arus dan beda potensial dilakukan setiap 4 jam selama 36 jam. Berdasarkan hasil penelitian yang dilakukan didapatkan nilai arus, beda potensial maksimum dan kerapatan daya masing-masing sebesar 1656 mV, 1582 µA dan 1794,37 mW/m2.Kata kunci: dua sel, microbial fuel cell, molase, Pseudomonas sp
Studi In Silico Potensi Antikanker Senyawa Kaempferida
Authors: Fadlan Arif , Warsito Tri , Sarmoko Sarmoko 
Published: June 2022

Active compounds as therapeutic agents are mainly found in natural products. Kaempferia pandurata from Kaempferia Genus has been used for the treatment of diseases. K. pandurata contains kaempferol (KMP) which exhibits various biological activities such as anticancer. KMP correlates to death-associated protein kinase 1 (DAPK1) relates to tumor suppression and apoptotic and autophagy mediation. This research aims to evaluate the anticancer potential of kaempferide (a methylated KMP at the C4’ position) against DAPK1 in silico. The research was performed through molecular docking to DAPK1 (5AUX and 5AV3), anticancer activity prediction, drug-likeness analysis, and ADMET (absorption, distribution, metabolism, excretion, and toxicology) evaluation. The binding affinity of kaempferide was -8.0 kcal/mol for 5AUX and 5AV3, respectively. The highest anticancer activity of kaempferide was shown against the prostate carcinoma cell line CWR22R. Kaempferide showed no violation to Lipinski-Veber rule and had good ADMET profile. Keywords: in silico, anticancer, kaempferide Senyawa aktif dengan potensi terapeutik banyak ditemukan dalam bahan alam. Kaempferia pandurata dari genus Kaempferia telah digunakan dalam pengobatan berbagai penyakit. K. pandurata mengandung kaempferol (KMP) dengan aktivitas biologis beragam, salah satunya adalah antikanker. KMP juga dapat berikatan dengan death-associated protein kinase 1 (DAPK1) yang berhubungan dengan penekanan tumor dan mediasi apoptosis dan autofagi. Penelitian ini mempelajari potensi antikanker kaempferida (KMP yang termetilasi pada posisi C4’) terhadap DAPK1 secara in silico. Penelitian dilakukan melalui penambatan molekular terhadap DAPK1 (5AUX dan 5AV3), perkiraan aktivitas antikanker, analisis drug-likeness, dan prediksi ADMET (absorption, distribution, metabolism, excretion, and toxicology). Afinitas ikatan kaempferida masing-masing sebesar -8,0 kkal/mol untuk 5AUX dan 5AV3. Aktivitas antikanker tertinggi kaempferida ditunjukkan terhadap cell line karsinoma prostat CWR22R. Kaempferida tidak melanggar aturan Lipinski-Veber sesuai analisis drug-likeness dan memiliki profil ADMET yang cukup baik. Kata kunci: in silico, antikanker, kaempferida
The Effect of Work Culture and Personality Toward Teacher’S Organizational Commitment on Public Junior High School - Kei Kecil - Southeast Maluku
Authors: Elewarin Subhan 
Published: June 2022

The objective of this causal research was to obtain information concerning: (1) the effect of work culture toward organizational commitment; (2) the effect of personality toward organizational commitment; and (3) the effect of work culture toward personality. The research was conducted by using a survey method with path analysis ini testing hypothesis. Ini this research, teachers on Public Junior High School – Kei Kecil-Southeast Maluku has been choosen as a unit analysis and 112 samples of teachers were selected in random. The results of the research are as follows: (1) there is a direct positive effect of work culture toward organizational commitment; (2) there is a direct positive effect of personality toward organizational commitment; and (3) there is a direct positive effect of work culture toward personality.
PENGARUH MODEL PEMBELAJARAN CORE (CONNECTING ORGANIZING REFLECTING EXTENDING) UNTUK MENINGKATKAN KETERAMPILAN BERPIKIR KRITIS SISWA
Authors: Wati Karlina , Hidayati Yunin , Wulandari Ana Yuniasti Retno , Ahied Mochamad 
Published: June 2022

Model CORE merupakan model pembelajaran yang dirancang untuk membangun keaktifan siswa sehingga siswa dapat lebih mudah menemukan pengetahuannya sendiri. Penelitian menggunakan model CORE bertujuan untuk mengetahui pengaruh model CORE (Connecting Organizing Reflecting Extending) untuk meningkatkan keterampilan berpikir kritis siswa dalam pembelajaran IPA khususnya materi cahaya. Metode penelitian dalam penelitian ini menggunakan pre experimental design dengan one group pretest posttest design. Sampel penelitian adalah siswa kelas VIII F. Teknik analisis data menggunakan uji t sampel berpasangan dan uji N-gain. Berdasarkan hasil penelitian dapat disimpulkan bahwa; 1) Ada pengaruh model pembelajaran CORE (Connecting Organizing Reflecting Extending) terhadap keterampilan berpikir kritis siswa yang dibuktikan nilai uji t sampel berpasangan, nilai –thitung ttabel thitung yakni 23,013 ˂ 2,05553 23,013 maka H1 diterima, 2) Keterampilan Berpikir kritis siswa setelah diterapkan model CORE mengalami peningkatan yang dibuktikan dari rata-rata nilai N-Gain sebesar 0,55 dengan kriteria sedang.
IDENTIFIKASI MISKONSEPSI SISWA SMP DENGAN CERTAINTY OF RESPONSE INDEX (CRI) PADA KONSEP SUHU DAN KALOR
Authors: Zayyinah Zayyinah , Munawaroh Fatimatul , Rosidi Irsad 
Published: June 2022

Tujuan dari penelitian ini adalah untuk mengidentifikasi miskonsepsi siswa pada konsep suhu dan kalor serta mendeskripsikan profil miskonsepsi yang terjadi. Subjek penelitian yang digunakan adalah siswa SMP Negeri 1 Ketapang kelas VII D sebanyak 30 orang. Instrumen penelitian yang digunakan adalah tes diagnostik dengan metode CRI (Certainty of Response Index) berbentuk pilihan ganda. Berdasarkan hasil tes, siswa dikelompokkan menjadi 3 kategori, yaitu paham konsep (PK), tidak paham konsep (TPK), dan miskonsepsi (M). Persentase siswa yang paham konsep sebesar 15,33%, tidak paham konsep sebesar 30,67%, miskonsepsi sebesar 54,00%. Persentase miskonsepsi tertinggi terjadi pada sub konsep perbedaan suhu dan kalor yaitu sebesar 57%.
Mengembangkan Kemampuan Sosial Melalui Pendekatan Project Based Learning
Authors: Puspitasari Ratna Nila , Al Baqi Safiruddin 
Published: June 2022

Kemampuan sosial anak penting untuk dikembangkan dikarena kemampuan sosial adalah kemampuan seorang anak untuk berinterkasi. Kemampuan sosial pada kelompok B masih rendah hal ini terlihat ketika anak diminta untuk melakukan kerjasama, mandiri dan bertanggung jawab anak masih belum mampu, dan berbagi dengan temannya pun belum mampu. Tujuan dari penelitian ini untuk mengembangkan kemampuan sosial dengan pendekatan project based learning kelompok B RA Muslimat Nu 050 Subulul Huda. Metode penelitian yang digunakan adalah penelitian tindakan kelas dengan model Kurt Lewin. Subjek dalam penelitian adalah semua anak di kelompok B sebesar 21 anak. Penelitian ini dilakukan dengan menggunakan 2 siklus yang terdiri dari 6 kali pertemuan, sehingga keseluruhan ada 12 kali pertemuan. Teknik analisis data adalah analisis data kualitatif dan kuantitatif. Hasil penelitian menunjukkan bahwa ada peningkatan kemampuan sosial anak yakni kemampuan sosial dalam hal bekerjasama, kemandirian, bertanggung jawab, dan anak berbagi dengan temannya. Hal ini dapat diketahui dari nilai prasiklus sampai dengan nilai siklus II, yang mana mengalami kenaikan sebesar 32. Berdasarkan hasil penelitian maka dapat disimpulkan bahwa pendekatan project based learning dapat mengembangkan kemampuan sosial anak. Kemampuan sosial anak dapat dikembangkan dengan pendekatan student center sesuai dengan prinsip Pendidikan anak usia dini yang mana pusat pembelajaran adalah anak.
Numerical Simulation of the Straight-Swirling Integrated Jet and Its Application in Natural Gas Hydrate Drilling
Authors: Zhang Yiqun , Wu Xiaoya , Zhao Shuai , Hui Chengyu , Li Gensheng , Li Jingbin , Lu Jingsheng , Zhang Bo 
Published: June 2022

Summary
Natural gas hydrate (NGH) is a potential clean energy source and is buried abundantly in seafloor sediments. Waterjet is a key technology involved in both the marine NGH solid fluidization exploitation method and the integrated radial jet drilling and completion method. To improve the efficiency of breaking and extracting NGH through a waterjet, a straight-swirling integrated jet (SSIJ) nozzle is designed based on the convergent-divergent geometry and impeller in this study. With a computational fluid dynamics method, the 3D model of SSIJ is constructed, and the characteristics of velocity field, pressure field, cavitation cloud distribution, and turbulence kinetic energy are analyzed, the results of which are compared with conical jet (CJ), convergent-divergent jet (CDJ), and swirling jet (SJ). Laboratory experiments of gas hydrate-bearing sediments (GHBS) erosion by the four kinds of jets mentioned above are conducted to evaluate the jet erosion performance based on the in-house experimental apparatus for NGH generation and cavitating jet erosion. Results indicate that the SSIJ can significantly enhance the breaking volume and efficiency of waterjet erosion on GHBS compared with the other three methods. The most important driving force for improved efficiency is the 3D velocity, which can induce axial impact stress, radial tensile stress, and circumferential shear stress on the impinged GHBS. Additionally, the insertion of an impeller with the center hole greatly improves the cavitation erosion performance of SSIJ. This paper illustrates the erosion performance of four kinds of waterjets in breaking GHBS and provides preliminary insights into the potential field applications in NGH exploitation.
Long-term follow-up of intrahepatic biliary cystadenoma and cystadenocarcinoma following hepatectomy
Authors: Chen Jiangming , Geng Wei , Zhao Yi-jun , Xie Kun , Wang Guo-bin , Geng Xiao-ping , Liu Fu-bao 
Published: June 2022

Abstract
Backgroud: We present our experiences, particularly long term followup, of 20 patients who underwent operations for BCA or BCAC over the last 15 years in an effort to formulate more effective management strategiesMethods: Clinical data on patients with pathologically confirmed BCA or BCAC between June 2002 and May 2017 were retrospectively analyzed.Results: Twenty patients were pathologically diagnosed with intrahepatic BCA (12) or BCAC (8); the mean ages for these 2 groups were 46.3 years and 62.0 years, respectively (P = 0.000). The main imaging feature for most BCA patients (83.3%) was cystic mass with septations. The main imaging features for BCAC were unilocular or unilocular cysts with papillary projections or solid portions. All BCAC patients received surgical treatment. No BCA patients developed recurrent cystadenoma after complete excision. Six (75 per cent) of the 8 BCAC patients died during a median follow-up time of 70.1months. Three deaths were due to metastasis. The median follow-up of BCAC patients without a recurrence was 116.5months (range 61–152).Conclusions: Factors associated with a higher likelihood of BCA or BCAC include being a middle-aged or older woman, having elevated serum CA19-9 levels, showing high-risk features on imaging, and having recurrent liver cyst(s). Radical excision is recommended to obtain long-term tumor-free survival.
Sources of Primary Bloodstream Infections in Internal Medicine Patients – a Cohort Study
Authors: Ben-Yosef Yonatan , Oster Yonatan , Cohen Matan J , Schwartz Carmela , Benenson Shmuel 
Published: June 2022

Abstract
Background
To describe the sources of bloodstream infections (BSIs) in internal-medicine patients, on admission and during hospitalization, and to determine the proportion of BSIs in which no secondary cause could be defined (i.e. primary-BSI).
Methods
We analyzed all BSIs at the internal-medicine wards of the two campuses of the Hadassah Hebrew-University Medical Center, during 2017–2018. We defined the BSI source of each event (secondary, Central-line associated BSI (CLABSI) or primary non-CLABSI) and compared BSIs present on admission (POA) to hospital acquired (HA).
Results
There were 595 patient-unique BSI events, 316 (53.1%) POA-BSI and 279 (46.9%) HA-BSI. Overall, 309 (51.9%) were secondary, 194 (32.6%) primary non-CLABSI and 92 (15.5%) CLABSI. Primary non-CLABSI in the POA-BSI group was 20.6% vs. 46.2% in the HA-BSI group (p = 0.001). The length of hospital stay (LOS) from culture to discharge of the HA-BSI group was longer than in the POA-BSI group (mean LOS, 19 days vs. 13.6 days, p = 0.01) and the mortality rate was higher (48.7% vs. 19%, p = 0.001). Staphylococcus aureus was more common in primary non-CLABSI than in CLABSI and secondary BSI (29.5%, 12.8% and 16.2%, respectively).
Conclusions
The proportion of primary non-CLABSI among HA-BSI events is very high (46.2%). The absence of any plausible source for these BSIs, and the fact that most patients in Internal-medicine wards have peripheral lines, suggests that the peripheral catheter is a probable source for primary non-CLABSIs. Measures to prevent peripheral line associated BSI (PLABSI), similar to those implemented successfully for the prevention of CLABSI, should be considered.
Multivariate statistical analysis and Geospatial approach for evaluating Hydro-geochemical characteristics of meltwater from Shaune Garang Glacier, Himachal Pradesh, India
Authors: Kumar Ramesh , Kumar Rajesh , Bhardwaj Anshuman , Singh Atar , Singh Shaktiman , Kumari Anupma , Sinha Ravindra Kumar 
Published: June 2022

Abstract
The study focuses on the hydro-geochemistry of Shaune Garang glacier's meltwater concerning glacial geomorphology. Seventy-nine water samples (53 in 2016 and 26 in 2017) of ablation season were analyzed. The cations were dominant in the order Ca2+ > Mg2+ > Na+ > K+, and the anions in the order HCO3− > SO42− > Cl− > NO3−. Ca2+. The result demonstrated that HCO3− were the abundant ions, accounting for 41.03 and 34.84% of the total ionic budget (TZ). The high ionic proportions of (Ca2++Mg2+) versus TZ+ and (Ca2++Mg2+) versus (Na++K+) were identified as the primary factors influencing dissolved ion chemistry in meltwater. Piper diagram shows that Ca2+– HCO3− type water is the most common, followed by Mg2+– HCO3−. In addition, a remote sensing approach has been used to find the possible source of the chemical constituents in the meltwater. The catchment geology has been mapped on various scales, including diverse rocks and unconsolidated surface materials containing "quartz and carbonate minerals". Layered silicates (LS) and "hydroxyl-bearing minerals" are not as common as they used to be, but their availability varies greatly in the area where they are found. The distribution of Layered silicate (LS) minerals within the catchment are majorly found at lower altitudes, which implies the weathering mechanism due to the interaction of meltwater and parental rock. Multivariate analysis revealed that CO3 and SiO2 weathering, sulphate dissolution, and pyrite oxidation dominate dissolved ion concentrations. Chemometric analysis of meltwater hydro-geochemistry through Principal Component Analysis (PCA) explains 72.1% of the total variance of four PCs. PCs 1, 2, 3 and 4 explain 39.21%, 12.91%, 10.24% and 9.74% of variance respectively in 2016. Similarly, in 2017, four PCs explain 69.9.1% of the total variance. PC 1, 2, 3 and 4 can explain 26.62%, 20.12%, 12.64% and 10.52% of variance.
Electrodeposited Magnetic Nanoporous Membrane (MNM) with a Multi-Edge Superparamagnetic Heterogeneous Wedge Junction for High-Yield and High-Throughput Immunocapture of Specific Extracellular Vesicles and Lipoproteins
Authors: Zhang Chenguang , Huo Xiaoye , Zhu Yini , Higginbotham James , Lu Xin , Franklin Jeffrey , Vickers Kasey , Coffey Robert , Senapati Satyajyoti , Wang Ceming , Chang Hsueh-Chia 
Published: June 2022

Abstract
Superparamagnetic nanobeads offer several advantages over microbeads for immunocapture of specific molecular nanocarriers (extracellular vesicles, lipoproteins, and viruses) in a bioassay: high-yield capture, reduction in incubation time, and higher capture capacity. However, nanobeads are difficult to “pull-down” because their superparamagnetic feature requires high nanoscale magnetic field gradients in addition to high magnetic fields. Here, an electroplated track-etched membrane is shown to produce a unique superparamagnetic nano edge ring with multiple edges around each nanopore. With a uniform external magnetic field, the induced monopole and dipole of this nano edge junction combine to produce a 10x higher nanobead trapping force. A dense nanobead suspension can be filtered through the magnetic nanoporous membrane (MNM) at high throughput with a 99% bead capture rate. The capture yield of specific nanocarriers in heterogeneous media (filtered plasma and conditioned cell media) by nano-beads/MNM exceeds 80%. Quantification of RNA cargo in captured extracellular vesicles demonstrates a 60x increase in the capture rate of a specific microRNA relative to magnetic bead columns. Reproducibility, low loss, and concentration-independent capture rates are also demonstrated. This new MNM material hence significantly expands the application of nanobead immunocapture to heterogeneous physiological samples, such as plasma and saliva.
Associative gene networks reveal novel candidates important for ADHD and dyslexia comorbidity
Authors: He Hongyao , Gao Xiaoyan , Liu FangFang , Zhang Jing , Zhong Lin , Zuo Pengxiang , Song Ranran 
Published: June 2022

Abstract
Background
Attention deficit hyperactivity disorder (ADHD) is in a close correlation with developmental dyslexia (DD), which are both prevalent and complicated pediatric neurodevelopmental disorders that significantly affect the learning and development of children. Clinically, the comorbidity incidence of DD and ADHD is between 25 and 48%. Children with DD and ADHD may have more severe cognitive deficiencies, a poorer level of schooling, and a higher risk of social and emotional management disorders. Furthermore, patients with this comorbidity are frequently treated for a single condition in clinical settings, and the therapeutic outcome is poor. The development of efficient therapies for the diseases turns sophisticated due to their comorbidity characteristics. It has long been a critical issue in diagnosis and treatment. In the current research, bioinformatical methodology was developed to analyze the comorbidity of the two diseases. Therefore, finding candidate genes associated with comorbid conditions of ADHD and DD contributes to interpretation of the molecular mechanisms in comorbid conditions, genotype and identification of novel drug targets.
Results
With the ANDSystem tool, gene networks related to ADHD and dyslexia were reconstructed and analyzed. The gene network for ADHD contained 599 genes/proteins and 148978 interactions, and that for dyslexia contained 167 genes/proteins and 27083 interactions. When the ANDSystem and GeneCard data were combined, a total of 213 genes/proteins for ADHD and dyslexia were found. A method that could rank genes in comorbid conditions of these two diseases was presented. This method followed 10 criteria of ranking genes based on importance, such as relevance scores of association between disease and genes, standard gene prioritization methods, and original criteria considering the features in an associative gene network and known polymorphisms of the analyzed genes. With the presented method, genes OPRM1, CHRNA4 and SNCA were found to have the highest priority in developing comorbidity of the two diseases. In addition, research showed the involvement of the most relevant genes in biological processes associated with signal transduction, positive regulation of transcription from RNA polymerase II promoters, chemical synaptic transmission, response to drugs, ion transmembrane transport, nervous system development, cell adhesion, as well as neuron migration.
Conclusions
Gene network reconstruction and analysis methods can be used in the study on the molecular mechanisms in comorbid conditions. The proposed method ranking genes based on importance in comorbid conditions of ADHD and dyslexia was used to predict genes that play key roles in the development of the comorbid condition. The findings provide a reference for experiments conducted to identify new candidate genes and find new pharmacological targets.