bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating classifiers in SE research: the ECSER pipeline and two replication studies
Authors: Dell’Anna Davide , Aydemir Fatma Başak , Dalpiaz Fabiano 
Published: November 2022

Abstract
Context
Automated classifiers, often based on machine learning (ML), are increasingly used in software engineering (SE) for labelling previously unseen SE data. Researchers have proposed automated classifiers that predict if a code chunk is a clone, if a requirement is functional or non-functional, if the outcome of a test case is non-deterministic, etc.

Objective
The lack of guidelines for applying and reporting classification techniques for SE research leads to studies in which important research steps may be skipped, key findings might not be identified and shared, and the readers may find reported results (e.g., precision or recall above 90%) that are not a credible representation of the performance in operational contexts. The goal of this paper is to advance ML4SE research by proposing rigorous ways of conducting and reporting research.

Results
We introduce the ECSER (Evaluating Classifiers in Software Engineering Research) pipeline, which includes a series of steps for conducting and evaluating automated classification research in SE. Then, we conduct two replication studies where we apply ECSER to recent research in requirements engineering and in software testing.

Conclusions
In addition to demonstrating the applicability of the pipeline, the replication studies demonstrate ECSER’s usefulness: not only do we confirm and strengthen some findings identified by the original authors, but we also discover additional ones. Some of these findings contradict the original ones.
Depression, Anxiety, Stress and Distress Following Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Results of a Prospective Cohort Study
Authors: Oswald Amy , McBride Kate , Seif Susan , Koh Cherry , Ansari Nabila , Steffens Daniel 
Published: November 2022

AbstractThe aim of this study was to describe the levels of depression, anxiety, stress, and distress in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). The 21-item Depression, Anxiety and Stress Scale (DASS-21) and Distress Thermometer were administered preoperatively, postoperatively day 10, and at hospital discharge to 169 patients with peritoneal carcinomatosis undergoing CRS and HIPEC. The mean preoperative values for DASS-21 subscale scores were 4.7 (depression), 4.2 (anxiety), and 8.4 (stress), and the mean preoperative Distress Thermometer rating was 4.0. No significant changes in levels of depression, stress, or distress were noted thereafter. The DASS-21 anxiety subscale score significantly increased at hospital discharge (p = .005). Higher levels of preoperative psychological depression, anxiety, stress and distress were associated with worse mental component scores. Higher preoperative depression levels were associated with the provision of more clinical psychologist occasions of service, and higher preoperative distress levels were associated with younger age. Preoperative psychological measures are important for ensuring CRS and HIPEC patients that require additional support are identified and provided with ongoing psychological interventions.
Assessing Unique Risk Factors for COVID-19 Complications Among Cancer Patients: A Multi-ethnic Cohort Study
Authors: Borno Hala T. , Kim Mi-Ok , Tolstykh Irina , Lin Amy , Hong Julian C. , Yousefi Sasha , Zhang Sylvia , McKay Rana R. , Harismendy Olivier , Razavi Pedram , Cinar Pelin , Rugo Hope , Koshkin Vadim S. , Rabow Maya , Wang Christine , Bailey Adina , Small Eric J. 
Published: November 2022

AbstractA myriad of organ-specific complications have been observed with COVID-19. While racial/ethnic minorities have been disproportionately burdened by this disease, our understanding of the unique risk factors for complications among a diverse population of cancer patients remains limited. This is a multi-institutional, multi-ethnic cohort study evaluating COVID-19 complications among cancer patients. Patients with an invasive cancer diagnosis and confirmed SARS-CoV-2 infection were identified from March to November 2020. Demographic and clinical data were obtained and a multivariate logistic regression was employed to evaluate the impact of demographic and clinical factors on COVID-19 complications. The study endpoints were evaluated independently and included any complication, sepsis, pulmonary complications and cardiac complications. A total of 303 patients were evaluated, of whom 48% were male, 79% had solid tumors, and 42% were Hispanic/Latinx (Hispanic). Malignant hematologic cancers were associated with a higher risk of sepsis (OR 3.93 (95% CI 1.58–9.81)). Male patients had a higher risk of sepsis (OR 4.42 (95% CI 1.63–11.96)) and cardiac complications (OR 2.02 (95% CI 1.05–3.89)). Hispanic patients had a higher odds of any complication (OR 2.31 (95% CI 1.18–4.51)) and other race was associated with a higher odds of cardiac complications (OR 2.41 (95% CI 1.01–5.73)). Clinically, fever, cough, and ≥2 co-morbidities were independently significantly associated with any complication. This analysis evaluated covariates that can significantly predict a myriad of complications among a multi-ethnic cohort of cancer patients. The conclusions drawn from this analysis elucidate a mechanistic understanding of differential illness severity from COVID-19.
You have to let go sometimes: advances in understanding goal disengagement
Authors: Kappes Cathleen , Schattke Kaspar 
Published: November 2022

AbstractWhile research on tenacious goal pursuit and persistence has evoked a myriad of research efforts, research on goal disengagement has rather been neglected and has been focusing mainly on positive consequences of individual differences in goal disengagement capacities. In recent years, however, research on goal disengagement has seen an upsurge in studies, specifically addressing the conceptualization of goal disengagement, the processes involved, and factors facilitating or undermining it. However, many questions remain unanswered or only partly answered providing numerous opportunities for further investigation.With this special issue of Motivation and Emotion, we aim to stimulate such progress in research on goal disengagement. To this end, this special issue includes empirical studies with cross-sectional, prospective, longitudinal, and experimental designs with a wide range of personal and experimentally induced goals as well as invited commentaries from scholars across different psychological sub disciplines.In this introductory essay, we provide a brief review of the current state of goal disengagement research. We also provide an overview about the contributions to this special issue with reflections related to the current state of research and areas where further advancement in conceptualization and empirical studies is needed.
Trends in extracellular matrix biology
Authors: Kyriakopoulou Konstantina , Piperigkou Zoi , Tzaferi Kyriaki , Karamanos Nikos K. 
Published: November 2022

AbstractExtracellular matrixes (ECMs) are intricate 3-dimensional macromolecular networks of unique architectures with regulatory roles in cell morphology and functionality. As a dynamic native biomaterial, ECM undergoes constant but tightly controlled remodeling that is crucial for the maintenance of normal cellular behavior. Under pathological conditions like cancer, ECM remodeling ceases to be subjected to control resulting in disease initiation and progression. ECM is comprised of a staggering number of molecules that interact not only with one another, but also with neighboring cells via cell surface receptors. Such interactions, too many to tally, are of paramount importance for the identification of novel disease biomarkers and more personalized therapeutic intervention. Recent advances in big data analytics have allowed the development of online databases where researchers can take advantage of a stochastic evaluation of all the possible interactions and narrow them down to only those of interest for their study, respectively. This novel approach addresses the limitations that currently exist in studies, expands our understanding on ECM interactions, and has the potential to advance the development of targeted therapies. In this article we present the current trends in ECM biology research and highlight its importance in tissue integrity, the main interaction networks, ECM-mediated cell functional properties and issues related to pharmacological targeting.
Persistence in firm growth: inference from conditional quantile transition matrices
Authors: Bottazzi Giulio , Kang Taewon , Tamagni Federico 
Published: November 2022

Abstract
We introduce a new methodology to investigate the degree of persistence in firm growth dynamics, based on Conditional Quantile Transition Probability Matrices (CQTPMs) and exact inferential tests derived from two well-known mobility indexes. We apply the methodology to study manufacturing firms in the UK and four major European economies over the period 2010–2017. We find that CQTPMs display more persistence than under a fully independent firm growth process, albeit considerable turbulence and significant bouncing effects are detected. Exploiting the inferential statistics within a regression framework, we show that productivity, openness to trade, and business dynamism are the primary sources of firm growth persistence across sectors, while country-specific and time-specific factors play a second-order role.
Untargeted metabolomics of human keratinocytes reveals the impact of exposure to 2,6-dichloro-1,4-benzoquinone and 2,6-dichloro-3-hydroxy-1,4-benzoquinone as emerging disinfection by-products
Authors: Meintani Dimitra G. , Chatzimitakos Theodoros G. , Kasouni Athanasia I. , Stalikas Constantine D. 
Published: November 2022

Abstract
Introduction
The 2,6-dichloro-1,4-benzoquinone (DCBQ) and its derivative 2,6-dichloro-3-hydroxy-1,4-benzoquinone (DCBQ-OH) are disinfection by-products (DBPs) and emerging pollutants in the environment. They are considered to be of particular importance as they have a high potential of toxicity and they are likely to be carcinogenic.

Objectives
In this study, human epidermal keratinocyte cells (HaCaT) were exposed to the DCBQ and its derivative DCBQ-OH, at concentrations equivalent to their IC20 and IC50, and a study of the metabolic phenotype of cells was performed.

Methods
The perturbations induced in cellular metabolites and their relative content were screened and evaluated through a metabolomic study, using 1H-NMR and MS spectroscopy.

Results
Changes in the metabolic pathways of HaCaT at concentrations corresponding to IC20 and IC50 of DCBQ-OH involved the activation of cell membrane α-linolenic acid, biotin, and glutathione and deactivation of glycolysis/gluconeogenesis at IC50. The changes in metabolic pathways at IC20 and IC50 of DCBQ were associated with the activation of inositol phosphate, pertaining to the transfer of messages from the receptors of the membrane to the interior as well as with riboflavin. Deactivation of biotin metabolism was recorded, among others. The cells exposed to DCBQ exhibited a concentration-dependent decrease in saccharide concentrations. The concentration of steroids increased when cells were exposed to IC20 and decreased at IC50. Although both chemical factors stressed the cells, DCBQ led to the activation of transporting messages through phosphorylated derivatives of inositol.

Conclusion
Our findings provided insights into the impact of the two DBPs on human keratinocytes. Both chemical factors induced energy production perturbations, oxidative stress, and membrane damage.
Distance mapping in three-dimensional virtual surgical planning in hand, wrist and forearm surgery: a tool to avoid mistakes
Authors: Honigmann Philipp , Keller Marco , Devaux-Voumard Noémie , Thieringer Florian M. , Sutter Damian 
Published: November 2022

Abstract
Purpose
Three-dimensional planning in corrective surgeries in the hand and wrist has become popular throughout the last 20 years. Imaging technologies and software have improved since their first description in the late 1980s. New imaging technologies, such as distance mapping (DM), improve the safety of virtual surgical planning (VSP) and help to avoid mistakes. We describe the effective use of DM in two representative and frequently performed surgical interventions (radius malunion and scaphoid pseudoarthrosis).

Methods
We simulated surgical intervention in both cases using DM. Joint spaces were quantitatively and qualitatively displayed in a colour-coded fashion, which allowed the estimation of cartilage thickness and joint space congruency. These parameters are presented in the virtual surgical planning pre- and postoperatively as well as in the actual situation in our cases.

Results
DM had a high impact on the VSP, especially in radius corrective osteotomy, where we changed the surgical plan due to the visualization of the planned postoperative situation. The actual postoperative situation was also documented using DM, which allowed for comparison of the VSP and the achieved postoperative situation. Both patients were successfully treated, and bone healing and clinical improvement were achieved.

Conclusion
The use of colour-coded static or dynamic distance mapping is useful for virtual surgical planning of corrective osteotomies of the hand, wrist and forearm. It also allows confirmation of the correct patient treatment and assessment of the follow-up radiological documentation.
Surface Degradation of Oil-Immersed Nomex Paper Caused by Partial Discharge of High-Frequency Voltage
Authors: Li Xiaonan , Zhang Wenxu , Wang Hong , Ma Xiping , Zhang Hongliang , Li Kangle , Qin Tong , Liu Kai , Yang Yan , Wu Guangning 
Published: November 2022

AbstractThe oil-paper insulation of high-frequency (HF) transformers frequently withstands high-frequency over-voltages at frequencies of several kHz and above. This leads to the occurrence of partial discharge (PD), which causes premature insulation failure in HF transformers. In order to investigate the effect of PD under high-frequency stresses on oil-impregnated Nomex paper, this paper analyzes the surface morphology, bond-broken types of the molecular chain, and product types formed for oil paper after PD degradation. Then, the damage mechanism of oil-immersed Nomex paper between high-frequency and AC stress is explored. The experimental results show that the branches of creepage do not exist in the oil-paper insulation during the entire discharge process under high-frequency stresses, and that their damage degree is higher than that of AC stress. This is mainly because the benzene ring of oil-impregnated Nomex paper is destroyed and opened caused by high-energy particles, the heating effect in HF discharge, and the bulk effect. These results help to improve the design theory of insulation structures and to develop PD-resistant insulation materials in HF transformers.
Delivering forestry courses online: experiences, lessons learned, and future of forestry online education in the Asia Pacific
Authors: Shrestha Anil , Crawford Jodi , Chen Hailan , Zhang Shiyi , Zhong Na , Zeng Michelle , Wang Guangyu 
Published: November 2022

AbstractInnovation in forestry education is needed to address changing contexts of the positionality of forests. This is particularly significant in the Asia–Pacific region, where deforestation and degradation are high. However, the accessibility of high-quality forestry education to address changing regional and global contexts is lacking. A series of innovative sustainable forest management (SFM) open education resource (OER) courses were developed and implemented to improve the accessibility of SFM education to enhance teaching quality, curriculum, and research capacity of universities in the Asia-Pacific Region. To evaluate the SFM-OER program in terms of student experiences, this study investigated student achievement, perceived success of the pedagogical approach and instructional design, and perceived effectiveness of the learning activities in promoting active and transformative learning through the assessment of a 1,191-course feedback survey between 2018 and 2020, including the global pandemic. This study revealed that the program attracted diverse student demographics, including a higher proportion of female students majoring in forestry, ecology, and other environmental studies. Their primary motivation to participate in the courses was to gain international experience, followed by the flexibility of online learning, mandatory course requirements, and earning course credits. Students were satisfied with the Canvas learning management system. Most students spent less than 5 to 10 h of their weekly time in the course and agreed or strongly agreed that the workloads were manageable. Students reflected positively on various learning activities and assignments, such as watching lecture videos, taking quizzes, reading and summarizing, having discussions, and peer review writing. However, they did not clearly prefer specific learning activities, signifying the importance of using diverse learning activities to satisfy diverse individual learning styles in online settings. This analysis contributes to the further development of student-centered pedagogical development for online learning and provides insight into the ways forward for online higher forestry education, while repurposing existing OER courses in a post-Covid-19 era.
Going public: evidence from stock and bond IPOs in Belgium, 1839–1935
Authors: Deloof Marc , de Jong Abe , Legierse Wilco 
Published: November 2022

AbstractWe investigate firms' initial stock and bond issues in public capital markets and explain fluctuations in these IPOs over time. We study Belgium from 1839 to 1935, which provides a setting with poor investor protection, no tax distortions, and changing regulations. We find that economic growth induces stock and bond IPOs and that the issuers time offerings such that they coincide with favorable market conditions. Even though in 1873, regulation was abruptly relaxed, we find no evidence of increases in the number of IPOs. Finally, we show that stock and bond IPOs do not interact when controlling for the determinants of these IPOs.
Basal Forebrain Cholinergic Innervation Induces Depression-Like Behaviors Through Ventral Subiculum Hyperactivation
Authors: Yu Nana , Song Huina , Chu Guangpin , Zhan Xu , Liu Bo , Mu Yangling , Wang Jian-Zhi , Lu Yisheng 
Published: November 2022

AbstractMalfunction of the ventral subiculum (vSub), the main subregion controlling the output connections from the hippocampus, is associated with major depressive disorder (MDD). Although the vSub receives cholinergic innervation from the medial septum and diagonal band of Broca (MSDB), whether and how the MSDB-to-vSub cholinergic circuit is involved in MDD is elusive. Here, we found that chronic unpredictable mild stress (CUMS) induced depression-like behaviors with hyperactivation of vSub neurons, measured by c-fos staining and whole-cell patch-clamp recording. By retrograde and anterograde tracing, we confirmed the dense MSDB cholinergic innervation of the vSub. In addition, transient restraint stress in CUMS increased the level of ACh in the vSub. Furthermore, chemogenetic stimulation of this MSDB-vSub innervation in ChAT-Cre mice induced hyperactivation of vSub pyramidal neurons along with depression-like behaviors; and local infusion of atropine, a muscarinic receptor antagonist, into the vSub attenuated the depression-like behaviors induced by chemogenetic stimulation of this pathway and CUMS. Together, these findings suggest that activating the MSDB-vSub cholinergic pathway induces hyperactivation of vSub pyramidal neurons and depression-like behaviors, revealing a novel circuit underlying vSub pyramidal neuronal hyperactivation and its associated depression.
The Evolution of Blue Carbon Science
Authors: Duarte de Paula Costa Micheli , Macreadie Peter I. 
Published: November 2022

Abstract‘Blue carbon’ was coined over a decade ago to describe the contribution of mangroves, seagrasses, and tidal marshes to carbon drawdown in coasts and oceans, concomitantly attracting attention of policy-makers and resource managers to their potential as a natural climate solution. Here, we explore the emergence and evolution of this relatively new research field through bibliometrics approaches to investigate patterns and trends in scientific publications through time. Our aim was to understand the evolution of blue carbon science, from where we came from and where we are now. We analysed 1,729 papers from 5,763 authors. Overall, the carbon-sink capacity of these ecosystems has been recognised long before the term ‘blue carbon’ was coined; with an annual percentage growth rate of 20% y− 1. Research attention was highest for mangroves (~ 38% of publications), followed by saltmarshes (~ 22%), and seagrasses (~ 18%); while ~ 16% of the studies included two or more blue carbon ecosystems and 5% of the studies focused on other ecosystems. The citation burst analysis showed that, in the 1990s, the hot topic (i.e., fast-growing topic) was related to the overall flux and dynamics of carbon, with a recent transition to the role of coastal vegetation to climate change mitigation from 2009. The term ‘blue carbon’ became a hot topic in 2017, with the strongest citation burst between 2017 and 2020. This bibliometric study draws the patterns and trends of blue carbon science and indicate that this field is evolving through time to focus more on the blue carbon role as nature climate solutions.
Advanced shifted first-kind Chebyshev collocation approach for solving the nonlinear time-fractional partial integro-differential equation with a weakly singular kernel
Authors: Atta A. G. , Youssri Y. H. 
Published: November 2022

AbstractThis research apparatuses an approximate spectral method for the nonlinear time-fractional partial integro-differential equation with a weakly singular kernel (TFPIDE). The main idea of this approach is to set up a new Hilbert space that satisfies the initial and boundary conditions. The new spectral collocation approach is applied to obtain precise numerical approximation using new basis functions based on shifted first-kind Chebyshev polynomials (SCP1K). Furthermore, we support our study by a careful error analysis of the suggested shifted first-kind Chebyshev expansion. The results show that the new approach is very accurate and effective.
The Puzzle of Architecture and Bureaucracy
Authors: Agarez Ricardo Costa , Floré Fredie , Devos Rika 
Published: November 2022

ABSTRACTArchitecture and bureaucracy: indissociable and irreconcilable? The two spheres are often seen in opposition — the latter curtailing the former’s creative power — yet might they not also overlap, partake and occasionally coincide in their processes? Dismissing the role of bureaucracy in architecture as extraneous or detrimental seems to hinder our capacity, as thinkers and producers of architecture, to work through this relationship and explore ways of dealing with a pervasive tool of contemporary societal organisation; whereas understanding the fraught relationship might help us bridge the gap that, in many contexts, separates architecture and the communities it exists to serve. This special collection explores how architecture and bureaucracy have negotiated their stances in the twentieth century. In particular, it aims to shed light on instances where knowledge of architecture was an element in, and a product of, the machinery of bureaucracy. Beyond the notion of bureaucracy in architecture as a site of imposition and control — and the vivid sentiments of frustration and deception it prompts — lies a terrain where less contrasted, more fine-grained actions and exchanges occur. The ways in which these two spheres relate are diverse and merit scholarly attention, as the articles that follow demonstrate.