bluuebunny/crossref_metadata_2025_split huggingface dataset:
A CO2‐Masked Carbene Functionalized Covalent Organic Framework for Highly Efficient Carbon Dioxide Conversion
Authors: He Chang , Si Duan‐Hui , Huang Yuan‐Biao , Cao Rong 
Published: July 2022

AbstractFree N‐heterocyclic carbenes (NHCs) are generally prepared by treatment of imidazolium precursors with strong alkali reagents, which usually produces inactive NHC dimers. This treatment would destroy porous supports and thus make supported NHC catalysts difficult to recovery and reuse. Herein, we report the first stable CO2‐masked N‐heterocyclic carbenes (NHCs) grafted on a porous crystalline covalent organic framework (COF). The stable NHC‐CO2moieties in the COF‐NHC‐CO2could be transformed in situ into isolated NHCs by heating, which exhibit superior catalytic performances in hydrosilylation and N‐formylation reactions with CO2. The NHC sites can reversibly form NHC‐CO2and thus can be easily recycled and reused while maintaining excellent catalytic activity. Density functional theory calculations revealed that NHC sites can be fully exposed after removal of CO2‐masks and rapidly react with silanes, which endows COF‐NHC with high catalytic activity.
Creating Frustrated Lewis Pairs in Defective Boron Carbon Nitride for Electrocatalytic Nitrogen Reduction to Ammonia
Authors: Lin Wenwen , Chen Hao , Lin Gaobo , Yao Siyu , Zhang Zihao , Qi Jizhen , Jing Meizan , Song Weiyu , Li Jing , Liu Xi , Fu Jie , Dai Sheng 
Published: July 2022

AbstractThe electrocatalytic nitrogen reduction reaction (NRR) on metal‐free catalysts is an attractive alternative to the industrial Haber–Bosch process. However, the state‐of‐the‐art metal‐free electrocatalysts still suffer from low Faraday efficiencies and low ammonia yields. Herein, we present a molecular design strategy to develop a defective boron carbon nitride (BCN) catalyst with the abundant unsaturated B and N atoms as Lewis acid and base sites, which upgrades the catalyst from a single “Lewis acid catalysis” to “frustrated Lewis pairs (FLPs) catalysis.” 14N2/15N2 exchange experiments and density functional theory (DFT) calculations reveal that FLPs can adsorb an N2 molecule to form a six‐membered ring intermediate, which enables the cleavage of N2 via a pull–pull effect, thereby significantly reducing the energy barrier to −0.28 eV. Impressively, BCN achieves a high Faraday efficiency of 18.9 %, an ammonia yield of 20.9 μg h−1 mg−1cat., and long‐term durability.
Regioselective Seeded Polymerization in Block Copolymer Nanoparticles: Post‐Assembly Control of Colloidal Features
Authors: Navarro Lucila , Thünemann Andreas F. , Yokosawa Tadahiro , Spiecker Erdmann , Klinger Daniel 
Published: July 2022

AbstractPost‐assembly modifications are efficient tools to adjust colloidal features of block copolymer (BCP) particles. However, existing methods often address particle shape, morphology, and chemical functionality individually. For simultaneous control, we transferred the concept of seeded polymerization to phase separated BCP particles. Key to our approach is the regioselective polymerization of (functional) monomers inside specific BCP domains. This was demonstrated in striped PS‐b‐P2VP ellipsoids. Here, polymerization of styrene preferably occurs in PS domains and increases PS lamellar thickness up to 5‐fold. The resulting asymmetric lamellar morphology also changes the particle shape, i.e., increases the aspect ratio. Using 4‐vinylbenzyl azide as co‐monomer, azides as chemical functionalities can be added selectively to the PS domains. Overall, our simple and versatile method gives access to various multifunctional BCP colloids from a single batch of pre‐formed particles.
Enhancing Li+ Transport in NMC811||Graphite Lithium‐Ion Batteries at Low Temperatures by Using Low‐Polarity‐Solvent Electrolytes
Authors: Nan Bo , Chen Long , Rodrigo Nuwanthi D. , Borodin Oleg , Piao Nan , Xia Jiale , Pollard Travis , Hou Singyuk , Zhang Jiaxun , Ji Xiao , Xu Jijian , Zhang Xiyue , Ma Lin , He Xinzi , Liu Sufu , Wan Hongli , Hu Enyuan , Zhang Weiran , Xu Kang , Yang Xiao‐Qing , Lucht Brett , Wang Chunsheng 
Published: July 2022

AbstractLiNixCoyMnzO2 (x+y+z=1)||graphite lithium‐ion battery (LIB) chemistry promises practical applications. However, its low‐temperature (≤ −20 °C) performance is poor because the increased resistance encountered by Li+ transport in and across the bulk electrolytes and the electrolyte/electrode interphases induces capacity loss and battery failures. Though tremendous efforts have been made, there is still no effective way to reduce the charge transfer resistance (Rct) which dominates low‐temperature LIBs performance. Herein, we propose a strategy of using low‐polarity‐solvent electrolytes which have weak interactions between the solvents and the Li+ to reduce Rct, achieving facile Li+ transport at sub‐zero temperatures. The exemplary electrolyte enables LiNi0.8Mn0.1Co0.1O2||graphite cells to deliver a capacity of ≈113 mAh g−1 (98 % full‐cell capacity) at 25 °C and to remain 82 % of their room‐temperature capacity at −20 °C without lithium plating at 1/3C. They also retain 84 % of their capacity at −30 °C and 78 % of their capacity at −40 °C and show stable cycling at 50 °C.
Revisiting the Dithienophthalimide Building Block: Improved Synthetic Method Yielding New High‐Performance Polymer Donors for Organic Solar Cells
Authors: Li Lianghui , Meng Fei , Zhang Ming , Zhang Zhi‐Guo , Zhao Dongbing 
Published: July 2022

AbstractImide‐functionalized arenes have been one of the most promising acceptor (A) units in organic solar cells (OSCs). However, dithienophthalimide (DPI), a hybrid of thieno‐[3,4‐c]pyrrole‐4,6‐dione (TPD) and bithiophene imide (BTI) units, has not been revisited since its first synthesis, likely owing to the high synthetic cost of the reported method. In this work, we simplified the synthetic procedure of the DPI skeleton with a significant reduction of the synthetic cost by using chromium‐mediated cyclization as the key chemistry. Using this method, two DPI‐based nonhalogenated D–A copolymers are synthesized. The binary OSCs based on pBDTT‐DPI‐Me : Y6 achieves a power conversion efficiency as high as 16.55 %, highlighting DPI as an attractive A‐unit for further exploration in OSCs.
Unusual Electron Donor‐Acceptor Sequenced NIR AIEgen for Highly Efficient Mitochondria‐Targeted Cancer Cell Photodynamic Therapy
Authors: Yu Kaiwu , Pan Jiayue , Tian Mei , Zhang Haoke , Jin Chentao , Zhang Hong , Mao Zhengwei , He Qinggang 
Published: July 2022

AbstractPhotodynamic therapy (PDT) is recognized to be a promising strategy for anticancer treatment. Considering the progressive application of PDT in clinical trials, highly efficient and photostable photosensitizers (PSs) are in strong demand. Aggregation‐induced emission (AIE) based PSs are promising phototheranostic materials for tumor imaging and PDT due to their high fluorescence efficiency and photostability. Herein, a mitochondria‐targeted PS, TPA‐2TCP with AIE characteristics is developed by adopting an acceptor‐π‐donor‐π‐acceptor (A‐π‐D‐π‐A) structure. The untypical sequence of the electron donors and electron acceptors endows the derived AIE PS with evident redshift of the absorption and emission, and efficient generation of reactive oxygen species. With the positively charged pyridinium groups, nanoparticulated AIE PS (TPA‐2TCP NPs) exhibits high cell binding efficiency towards 4T1 breast cancer cells, leading to the massive cell death via the apoptotic pathway under white light irradiation, demonstrating its potential application in cancer imaging and PDT.
Distributed adaptive generalized Nash equilibrium seeking algorithm with event‐triggered communication
Authors: Cai Xin , Nan Xinyuan , Gao Bingpeng 
Published: July 2022

AbstractA class of aggregative games with coupled constraints is considered in this paper. The problem of seeking generalized Nash equilibrium (GNE) for the game with double‐integrator multi‐agent systems on weight‐balanced directed graphs is studied. To remove the convergence conditions related to the Laplacian matrix of the communication graph, adaptive parameters are introduced in the designed seeking algorithm. Moreover,an event‐triggered broadcasting scheme is designed to reduce communication loads when agents execute the seeking algorithm. It is shown that the designed algorithm can globally asymptotically converge to the GNE of the game and the proposed event‐triggered scheme is free of the Zeno behavior. A numerical example is illustrated to validate the proposed methods.
Framing the evolution of the “environmental strategy” concept: Exploring a key construct for the environmental policy agenda
Authors: Martín‐de Castro Gregorio , Amores‐Salvadó Javier , Díez‐Vial Isabel 
Published: July 2022

AbstractIn this paper, we develop a quantitative review of the evolution of the concept of environmental strategy. We show how it has formed the backbone of the development of firm strategy and the natural environment as a research tradition and how consensus regarding it has evolved in the academic community during the stages of its historical evolution. We us co‐word analyses to address changes in the structure of its definitional landscape and how it has evolved through the analysis of centrality of its core and periphery keywords. Furthermore, we develop, by the first time, a cluster analysis to identify the main definitional factors behind definitions along the two periods analyzed. Finally, four propositions for future development and a consensual definition of environmental strategy are proposed.
The effect of distance on the moral judgment of environmental wrongdoings
Authors: Grolleau Gilles , Ibanez Lisette , Mzoughi Naoufel 
Published: July 2022

AbstractEnvironment‐related decisions can be taken in situ or remotely. We discuss theoretically why and how this seemingly irrelevant factor, that is, the distance between the place of decision and the place where it is applied, affects the moral judgment by external third parties. We mobilize the out‐group bias and the construal level theory to predict that distant decisions will be judged more severely than close equivalent ones. Using an experimental survey, we test whether an identical decision regarding an environmental wrongdoing is judged differently when observers are informed that the decision has been taken in situ or remotely. The findings support that the distance between decision centers and application places matters. An increase in spatial distance leads to a more severe judgment of an otherwise identical decision. We draw implications for business environmental strategy and suggest the existence of a liability of distance in the moral domain.
Real‐world KINDLE‐Latin America subset data on treatment patterns and clinical outcomes in patients with stage III non‐small‐cell lung cancer
Authors: Martin Claudio Marcelo , Puello‐Guerrero Adrián , Mas‐Lopez Luis Alberto , Campos‐Gómez Saul , Orlando‐Orlandi Francisco J. , Tejado Gallegos Luis Fernando , Huggenberger Reto 
Published: July 2022

AbstractIntroductionStage III non‐small‐cell lung cancer (NSCLC) management is challenging given the heterogeneous nature of the disease. The LATAM subset of the real‐world, global KINDLE study reported the treatment patterns and clinical outcomes for LATAM from the pre‐immuno‐oncology era.MethodsThe study was conducted in seven countries (Argentina, Chile, Colombia, Dominican Republic, Mexico, Peru and Uruguay) in stage III NSCLC (American Joint Committee on Cancer, 7th edition) diagnosed between January 2013 and December 2017. Retrospective data from patients' medical records (index date to the end of follow‐up) were collected. Summary statistics, Kaplan–Meier survival estimates and a two‐sided 95% confidence interval (CI) were provided. Cox proportional hazard model was used for univariate and multi‐variate analyses.ResultsA total of 231 patients was enrolled, the median age was 65.0 years (range 21.0–89.0), 60.6% were males, 76.6% had smoking history, 64.0% had adenocarcinoma and 28.7% underwent curative resection. Multiple treatment regimens (>25) were used; chemotherapy alone was the most common (24.8%). The overall median progression‐free survival (mPFS) and median overall survival (mOS) were 14.8 months (95% CI, 12.1–18.6) and 48.6 months (95% CI, 34.7 to not calculable). Significantly better mPFS and mOS were observed for stage IIIA with curative surgery and resectable tumours and stage IIIB with an Eastern Cooperative Oncology Group score of 0/1, female gender, resectable tumours, adenocarcinoma and curative surgery (p < 0.05).ConclusionResults show diversity in treatment practices and the corresponding clinical outcomes in stage III NSCLC. There is a need to streamline treatment selection and sequencing to decrease relapse rates after initial therapy.
Identification and functional analysis of N6‐methyladenine (m6A)‐related lncRNA across 33 cancer types
Authors: Xu Dahua , Xu Zhizhou , Bi Xiaoman , Cai Jiale , Cao Meng , Zheng Dehua , Chen Liyang , Li Peihu , Wang Hong , Wu Deng , Yang Jun , Li Kongning 
Published: July 2022

AbstractBackgroundN6‐methyladenosine (m6A) plays an essential role in tumorigenesis and cancer progression. Long noncoding RNAs (lncRNAs) are discovered to be important targets of m6A modification, and they play fundamental roles in diverse biological processes. However, there is still a lack of knowledge with regards to the association between m6A and lncRNAs in human tumors.MethodsThe relationship between lncRNAs and 21 m6A regulators was comprehensively explored, through the integration of multi‐omics data from M6A2Target, m6A‐Atlas, and TCGA (The Cancer Genome Atlas). In order to explore the potential roles of m6A‐related lncRNAs in human tumors, three applicable methods were introduced, which include the construction of ceRNA networks, drug sensitivity estimation, and survival analysis.ResultsA substantial number of positive correlation events across 33 cancer types were found. Moreover, cancer‐specific lncRNAs were associated with tissue specificity, and cancer‐common lncRNAs were conserved in cancer‐related biological function. In particular, the m6A‐related lncRNA FGD5‐AS1 was found to be associated with cancer treatment, through its influence on cisplatin resistance in breast cancer patients. Finally, a user‐friendly interface Lnc2m6A, which is enriched with various browsing sections resource for the exhibition of relationships and putative biogenesis between lncRNAs and m6A modifications, is offered in http://hainmu‐biobigdata.com/Lnc2m6A.ConclusionsIn summary, the results from this paper will provide a valuable resource that guides both mechanistic and therapeutic roles of m6A‐related lncRNAs in human tumors.
Establishment of a risk model by integrating hypoxia genes in predicting prognosis of esophageal squamous cell carcinoma
Authors: Xiao Wanyi , Tang Peng , Sui Zhilin , Han Youming , Zhao Gang , Wu Xianxian , Yang Yueyang , Zhu Ningning , Gong Lei , Yu Zhentao , Zhang Hongdian 
Published: July 2022

AbstractBackgroundEsophageal squamous cell carcinoma (ESCC) has a dismal prognosis, and hypoxia plays a key role in metastasis and proliferation of ESCC. Thus, we aimed to develop a hypoxia‐based gene signature to assist in the treatment decisions and prognosis.MethodsWe performed consensus clustering analysis on samples from GSE53625 dataset from the Gene Expression Omnibus (GEO) database and used weighted gene co‐expression network analysis to filter out candidate modules, which were then intersected with differentially expressed genes from clustered subgroups to obtain hypoxia‐related genes (HRGs). After that, the aforementioned genes were used to construct risk score models and validated in The Cancer Genome Atlas (TCGA) database and Cox regression analysis were used to construct a nomogram. Immunohistochemical was used to detect protein expression levels of relevant genes. Moreover, the relationship between risk scores and tumor microenvironment was explored.ResultsA hypoxia risk model containing six genes (PNPLA1, CARD18, IL‐18, SLC37A2, ADAMTS18, and FAM83C) was constructed by screening key HRGs. Poorer prognosis in the high‐risk group than in the low‐risk group. And Cox regression analysis showed that risk score was an independent prognostic factor. The nomogram based on risk scores could well predict 1‐, 3‐, and 5‐year survival. P53, Wnt, and hypoxia signaling pathways may be some regulatory mechanisms of hypoxia associated with the tumor microenvironment. In addition, we confirmed the high expression of BGN and low expression of IL‐18 in ESCC tissues.ConclusionsOur study determined the prognostic value of a 6‐hypoxia gene signature and a prognostic model, providing potential prognostic predictors and therapeutic targets for ESCC.
Oral administration of botryosphaeran [(1 → 3)(1 → 6)‐β‐d‐glucan] reduces inflammation through modulation of leukocytes and has limited effect on inflammatory nociception
Authors: Silva Nubia A. , Pereira Bianca G. , Santos Joyce A. , Guarnier Flávia A. , Barbosa‐Dekker Aneli M. , Dekker Robert F. H. , Kassuya Cândida A. L. , Bernardes Sara S. 
Published: July 2022

AbstractSeveral biological activities of the fungal exopolysaccharide (1 → 3)(1 → 6)‐β‐d‐glucan (botryosphaeran) have been described in the literature, but its effects on inflammation have not been evaluated. This study aimed to investigate the action of botryosphaeran on experimental mice models of carrageenan‐induced acute pleurisy and acute paw edema, and complete Freund's adjuvant‐induced persistent paw edema. All botryosphaeran doses tested (1.0, 2.5, 5.0, and 10.0 mg/kg birth weight [b.w.], orally administered) reduced leukocyte recruitment, nitric oxide (NO) levels, and protein extravasation in the pleural cavity. Botryosphaeran (5 mg/kg b.w.) did not diminish edema and mechanical hyperalgesia in the paw within 4 h; however, cold allodynia was alleviated within the first 2 h. In the persistent paw inflammation model, the effects of daily oral administration of botryosphaeran (5 mg/kg b.w.) were evaluated over 3 and 7 days. The fungal β‐glucan significantly reduced the levels of the cytokines, tumor necrosis factor(TNF)‐α, interleukin (IL)‐6), and IL‐10, in the paw homogenates in both protocols, while paw edema and the levels of advanced oxidation protein products (AOPP) only diminished on Day 7. No effect in mechanical hyperalgesia was observed. Oral treatment for 3 or 7 days also decreased the plasma levels of NO, AOPP, TNF‐α, and IL‐10. On Day 7, the number of leukocytes in the blood was also reduced by this treatment. Importantly, botryosphaeran did not induce inflammation in mice when administered alone over 7 days. This study demonstrated the anti‐inflammatory and antinociceptive potential of botryosphaeran in these experimental models, making this fungal β‐glucan a new possibility for complementary treating acute and chronic inflammation.
HDACs regulate the differentiation of endothelial cells from human iPSCs
Authors: Li Tao , Wu Haopeng , Wang Pingping , Kim Amy M. , Jia Junjing , Nolta Jan A. , Zhou Ping 
Published: July 2022

AbstractHuman induced pluripotent stem cells (hiPSCs) possess the potential to differentiate toward vascular cells including endothelial cells (ECs), pericytes, and smooth muscle cells. Epigenetic mechanisms including DNA methylation and histone modification play a crucial role in regulating lineage differentiation and specification. Herein, we utilized a three‐stage protocol to induce differentiation of mesoderm, vascular progenitors, and ECs from hiPSCs and investigated the regulatory effects of histone acetylation on the differentiation processes. We found that the expression of several histone deacetylases (HDACs), including HDAC1, HDAC5, and HDAC7, were greatly upregulated at the second stage and downregulated at the third stage. Interestingly, although HDAC1 remained in the nucleus during the EC differentiation, HDAC5 and HDAC7 displayed cytosol/nuclear translocation during the differentiation process. Inhibition of HDACs with sodium butyrate (NaBt) or BML210 could hinder the differentiation of vascular progenitors at the second stage and facilitate EC induction at the third stage. Further investigation revealed that HDAC may modulate the stepwise EC differentiation via regulating the expression of endothelial transcription factors ERG, ETS1, and MEF2C. Opposite to the expression of EC markers, the smooth muscle/pericyte marker ACTA2 was upregulated at the second stage and downregulated at the third stage by NaBt. The stage‐specific regulation of ACTA2 by HDAC inhibition was likely through regulating the expression of TGFβ2 and PDGFB. This study suggests that HDACs play different roles at different stages of EC induction by promoting the commitment of vascular progenitors and impeding the later stage differentiation of ECs.
RETRACTED: High‐Resolution Imaging of Human Cancer Proteins Using Microprocessor Materials
Authors: Solares Maria J. , Jonaid G. M. , Luqiu William Y. , Berry Samantha , Khadela Janki , Liang Yanping , Evans Madison C. , Pridham Kevin J. , Dearnaley William J. , Sheng Zhi , Kelly Deborah F. 
Published: July 2022

AbstractMutations in tumor suppressor genes, such as Tumor Protein 53 (TP53), are heavily implicated in aggressive cancers giving rise to gain‐ and loss‐of‐function phenotypes. While individual domains of the p53 protein have been studied extensively, structural information for full‐length p53 remains incomplete. Functionalized microprocessor chips (microchips) with properties amenable to electron microscopy permitted us to visualize complete p53 assemblies for the first time. The new structures revealed p53 in an inactive dimeric state independent of DNA binding. Residues located at the protein‐protein interface corresponded with modification sites in cancer‐related hot spots. Changes in these regions may amplify the toxic effects of clinical mutations. Taken together, these results contribute advances in technology and imaging approaches to decode native protein models in different states of activation.
Modeling Thermophysical Properties of Carbon Dioxide: Performance Comparison and Assessment
Authors: Ding Lu , Zhao Bingtao , Hao Xiaohong 
Published: July 2022

AbstractAlthough many mathematical models have been developed for predicting the density, viscosity, and thermal conductivity of CO2, their accuracy and applicability have not been sufficiently established in the gas/liquid and supercritical regions and, in particular, in the region around the critical point. To understand their performances, the models are compared and analyzed, including (i) the cubic equations of state, multi‐parameter equations, and the Helmholtz free energy‐based model for density, (ii) residual theory‐ and regression‐based models for viscosity and thermal conductivity, and (iii) artificial intelligence‐based models (neural networks/machine learning) for these properties. A technical assessment is then performed. The results may provide a positive reference for determining the thermophysical properties of CO2.