bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ameliorative effects of supranutritional selenium on TLR‐4‐NF‐kB‐TNF‐α‐mediated hepatic oxidative injury and inflammation in goats fed high concentrate diet
Authors: Shah Tahmina , Malhi Moolchand , Kachiwal Allah Bux , Bhutto Bachal , Shah Qurban Ali , Lei Yan , Soomro Saeed Ahmed , Soomro Jamila , Kalhoro Nazeer Hussain , Gui Hongbing 
Published: July 2022

AbstractWe examined whether surplus dietary selenium (Se) supply could alleviate high concentrate (HC) diet‐induced hepatic oxidative stress (OS) and inflammation. Eighteen young goats were distributed into three groups; were fed low (LC, concentrate: forage; 35: 65), high concentrate (HC, 65: 35), or Se‐supplemented HC (HCSe, 65: 35 + 0.5 mg Se kg−1 diet) diets for 10 weeks. Short chain fatty acids, OS markers and immunoinflammatory genes expressions were assessed through gas chromatograph, kits, and RT‐qPCR, respectively. Compared with LC, HC diet increased (p < .05) colonic and serum lipopolysaccharide (LPS) levels and induced hepatic oxidative injury by increasing (p < .05) malondialdehyde (MDA) levels and decreasing (p < .05) activities of glutathione peroxidase, superoxide dismutase, and catalase. HC diet altered hepatic mRNA expressions of toll‐like receptor‐4 (TLR‐4), cluster of differentiation‐14 (CD‐14), tumor necrosis factor‐α (TNF‐α), TNF receptor‐associated factor‐6 (TRAF‐6), nuclear factor kappa B (NF‐κB), interleukin‐1β (IL‐1β), IL‐10, IL‐13, LPS‐binding protein (LBP), serum amyloid A (SAA), α‐acid glycoprotein (AGP), and albumin (ALB). Conversely, extra‐Se supply lowered LPS and attenuated antioxidant status and inflammation in liver. In conclusion, HC diet induced oxidative lesions and TLR‐4 pathway‐mediated inflammation, whereas supranutritional Se alleviated oxidative and inflammatory lesions through TLR‐4 pathway regulation in goat liver.
Unilateral vulval edema as the presenting cutaneous manifestation of Crohn's disease
Authors: Ling Hua Yen , Lim Shi Yu Derek , Lim Hua‐Liang Joel 
Published: July 2022

SynopsisVulval edema is an archetypal manifestation of metastatic Crohn's disease, which may predate clinical presentation of gastrointestinal Crohn's disease.
CAR T cell therapy in advanced B‐ALL with heavy disease burden
Authors: Tang Kaiting , Ling Zhuojun , Pan Jing , Huang He 
Published: July 2022

AbstractIn recent years, CD19‐directed chimeric antigen receptor (CAR) T cell therapy has exhibited significant potency for treating pediatric relapsed or refractory B‐cell acute lymphoblastic leukemia (r/r B‐ALL). Nonetheless, many patients with disease progressing rapidly may not benefit from this therapy. Actually, 10%–20% of these patients with rapidly progressive disease failed in CAR T cell manufacturing. Besides, some patients died of disease progression earlier than CAR T cells expanding in vivo. How to deal with the fast progressive disease and ensure successful manufacturing and expansion of CAR T cells are still very important questions for the clinicians. In this brief report, some clinical experience to handle these tough situations in our center will be introduced. Bridging chemotherapy and post‐CAR antitumor managements help to control progressive blasts and contribute to the success of CAR T cell therapy. The optimal timing of apheresis and adjusted protocol for manufacturing CAR T cells are critical for advanced patients. Optimal treatment options and how they should be applied to advanced B‐ALL with heavy disease burden still need to be discussed.
Fused thiophene based materials for organic thin‐film transistors
Authors: Velusamy Arulmozhi , Afraj Shakil N. , Yau Shuehlin , Liu Cheng‐Liang , Ezhumalai Yamuna , Kumaresan Prabakaran , Chen Ming‐Chou 
Published: July 2022

AbstractThis review highlights our recent efforts in the development of organic semiconductors based on anthradithiophene (ADT), dithienothiophene (DTT), tetrathienoacene (TTA), benzothienodithiophene (BTDT), benzothienothiophene (BTT), chalcogen‐planarized BT, and some quinoidal oligothiophenes for the application of organic thin‐film transistors (OTFTs). We visualized various strategies that have been employed in molecular architecture to improve the stability as well as solubility, and the energy levels are tuned for efficient hole/electron injection, thus leading to high‐performance solution processable OTFTs. The obtained mobility was correlated with the molecular stacking pattern and film morphology/microstructure of the semiconductors. Overall, this review presents information that aids reliable OTFT data analysis and provide guidelines for the development of next‐generation organic semiconductors. At present, the p‐type and n‐type OTFTs developed by our group are able to reach the mobilities of over 4.01 and 2.5 cm2V−1 s−1, respectively. In addition, we also demonstrated the utilization of these conjugated moieties in development of high performance dye‐sensitized solar cells (DSSCs) and hole transporting materials (HTM) as well as non‐fullerene acceptor (NFA) for perovskite solar cells (PSCs).
Percentile curves of normal echocardiographic measurements values for left heart structures in 1570 Han Chinese preterm and term infants
Authors: Wang Shanshan , Fu Jihe , Wu Lijun , Liu Xing‐Yuan , Zhang Yuqi 
Published: July 2022

AbstractObjectiveThis study was designed to evaluate echocardiographic measurements in Han Chinese preterm and term infants and to build percentile curves of normal echocardiographic measurements values related to the weight.MethodFrom December 2014 to December 2021, a total of 797 male infants and 773 female infants born in * were included in the study. The echocardiographic measurements of each subject were as follows: left ventricular internal diameter at end‐diastole (LVIDd), left ventricular internal diameter at end‐systole (LVIDs), left ventricular posterior wall thickness at end‐diastole (LVPWd), left ventricular posterior wall thickness at end‐systole (LVPWs), interventricular septal thickness at end‐diastole (IVSd), interventricular septal thickness at end‐systole (IVSs), ascending aorta diameter (AO), left atrium (LA) dimension, left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS) and left ventricular mass (LVM). The correlations between echocardiography measurements and birth weight (BW), length (L), gestational age (GA), and body surface area (BSA) were analyzed.ResultsThere was a good correlation between the echocardiographic measurements and birth weight and percentile curves of the echocardiographic measurements were established according to different birth weight. The echocardiographic measurements were not affected by gender. However, LVEF and LVFS did not change with BW or gender.ConclusionsThe percentile curves of normal values make it possible to classify echocardiographic measurements for left heart structures and function as normal or abnormal and is helpful for the diagnosis of neonatal heart disease in preterm and term infants.
Knowledge transfer for R&D‐sales cross‐functional cooperation: Unpacking the intersections between institutional expectations and human resource practices
Authors: Lindblom Jan , Martins Jorge Tiago 
Published: July 2022

AbstractThis article addresses the challenges of R&D–sales cross‐functional cooperation by exploring how HR practices encourage knowledge transfer, minimising peer‐to‐peer friction and maximising the effectiveness of the exchanges for performance innovation. We combined document analysis of professional HR management magazines and semi‐structured interviews at a Finnish digital media firm, in order to identify manifestations of institutional work expressing and legitimising knowledge transfer‐focused HR management practices, and how employees make sense of them. Our findings identify manifestations of institutional work expressing, sustaining and legitimising knowledge transfer and relate these manifestations to distinct dimensions of human resource management practices. We integrate prevailing institutional expectations and employees' attributions of knowledge transfer‐focused human resource practices, which highlights the connections between human resource management and the knowledge management field, as well as the dichotomy between the more humanist knowledge transfer strategies and those that are information technology‐oriented. Our original integration of institutional expectations and a case analysis of employees' attributions of knowledge transfer‐focused human resource practices contribute directly to management practice dealing with the effects of organising strategically for knowledge‐based innovation outcomes. This has implications in terms of the development of interpersonal skills, the engagement and development of cross‐team work; the design of participative mechanisms; and the implementation of knowledge transfer principles, practices and systems.
Filtration of Paint‐Contaminated Water by Electrospun Membranes
Authors: Müller Ann‐Kathrin , Xu Zhi‐Kang , Greiner Andreas 
Published: July 2022

AbstractMicro‐ and nanosized plastics as persistent anthropogenic pollutants have attracted more and more attention in recent years. A source of nanoparticles is, for example, water‐borne dispersion paint, which consists of a variety of different materials with potential adverse effects on living systems. Therefore, a rising challenge becomes apparent to investigate remediation strategies for environmental media. This problem is addressed by utilizing electrospun membranes for filtration applications because of their outstanding properties, such as their high surface‐to‐volume ratio and ease of functionalization. The electrospun membranes are able to successfully filter different paint components, such as titanium dioxide and polyacrylate nanoparticles, as well as dispersed polymers and calcium carbonate microparticles. Besides the known size‐exclusion mechanism, the membranes featured extraordinary properties, such as effective separation of components smaller than the pore size of the electrospun membranes. This property occurs due to the fiber surface functionalization and enables not only filtration of nanosized or dissolved mater at high filtration efficiencies up to 100% but also at a very low operating pressure. This combination of filter material properties cannot be achieved by conventional nanofiltration membranes and thus, demonstrates the high potential of electrospun membranes for the application in filtration for future environmental pollutants.
Molecular and expressional characterization of tumor heterogeneity in pulmonary carcinosarcoma
Authors: Ohtaki Yoichi , Kawabata‐Iwakawa Reika , Nobusawa Sumihito , Goto Yusuke , Shimizu Kimihiro , Yajima Toshiki , Nakazawa Seshiru , Kawatani Natsuko , Yoshida Yuka , Sano Takaaki , Shirabe Ken 
Published: July 2022

AbstractThe genetic concordance and heterogeneity of the two components of pulmonary carcinosarcoma (PCS), carcinoma, and sarcoma, have not been fully elucidated because of its rare occurrence. We performed targeted sequencing of the carcinoma and sarcoma components of four PCSs to identify genetic similarities and differences. Formalin‐fixed paraffin‐embedded tissue samples were macroscopically or microscopically dissected. DNA was extracted from each component, and genetic alterations were analyzed separately. Moreover, we performed RNA‐seq analysis on both components of one PCS to compare differences in gene expression profiles. The carcinoma part consisted of adenocarcinoma in two cases, squamous cell carcinoma in one, and adenosquamous carcinoma in the last. TP53 mutation was observed in three samples from the trunk, although it was detected only in the sarcoma part in one case. No specific driver gene mutation was observed; however, KRAS mutations were observed in one case in the trunk. RNA‐seq analysis revealed that the rhabdomyosarcoma component expressed various genes related to muscle development, whereas the carcinoma component did not; and that gene expression overall was completely different between the two components. Our study revealed that the two different components of PCS shared common gene mutations in most cases. Although gene expression was different among components, if driver genes such as KRAS were detected in PCS, molecular targeted therapy could be beneficial even when the tumor contains a sarcoma component.
T2′ mapping of the brain from water‐unsuppressed 1H‐MRSI and turbo spin‐echo data
Authors: Zhang Tianxiao , Guo Rong , Li Yudu , Zhao Yibo , Li Yao , Liang Zhi‐Pei 
Published: July 2022

PurposeTo obtain high‐quality maps of brain tissues from water‐unsuppressed magnetic resonance spectroscopic imaging (MRSI) and turbo spin‐echo (TSE) data.Methods mapping can be achieved using mapping from water‐unsuppressed MRSI data and mapping from TSE data. However, mapping often suffers from signal dephasing and distortions caused by field inhomogeneity; measurements may be biased due to system imperfections, especially for ‐weighted image with small number of TEs. In this work, we corrected the field inhomogeneity effect on mapping using a subspace model‐based method, incorporating pre‐learned spectral basis functions of the water signals. estimation bias was corrected using a TE‐adjustment method, which modeled the deviation between measured and reference decays as TE shifts.ResultsIn vivo experiments were performed to evaluate the performance of the proposed method. High‐quality maps were obtained in the presence of large field inhomogeneity in the prefrontal cortex. Bias in measurements obtained from TSE data was effectively reduced. Based on the and measurements produced by the proposed method, high‐quality maps were obtained, along with neurometabolite maps, from MRSI and TSE data that were acquired in about 9 min. The results obtained from acute stroke and glioma patients demonstrated the feasibility of the proposed method in the clinical setting.ConclusionsHigh‐quality maps can be obtained from water‐unsuppressed 1H‐MRSI and TSE data using the proposed method. With further development, this method may lay a foundation for simultaneously imaging oxygenation and neurometabolic alterations of brain disorders.
Factors associated with hand bone changes in early rheumatoid arthritis
Authors: Valner Annika , Kirsimägi Ülle , Müller Raili , Kull Mart , Põlluste Kaja , Kumm Jaanika , Lember Margus , Kallikorm Riina 
Published: July 2022

AbstractBackgroundThe aim of this research was to assess if hand bone mineral density (HBMD) changes associated with the appearance of erosions in early rheumatoid arthritis (ERA), compared with the population‐based control group. Additionally, we tried to identify if there are novel factors that associate with HBMD and erosive changes (EC), and if they are dissimilar. The study was conducted as the data are limited.MethodsThe study group consisted of 83 ERA patients and 321 controls. Dual‐Energy X‐Ray Absorptiometry (DXA) machine was used to measure HBMD. EC of RA (rheumatoid arthritis) were assessed in X‐rays of hands using Sharp scores. Life‐style habits, inflammation markers were assessed to evaluate the effects of different factors.ResultsThe presence of ERA was associated with lower HBMD compared with controls (adjusted for age, gender, height and weight; b −0.01, p = 0.045). 76% (95% CI 65.3–84.6) of ERA patients had EC in hand X‐ray. Smoking habits and higher BMI (body mass index) were associated with an increased likelihood of having RA specific EC. In ERA, decreasing of HBMD was associated with the elevation of interleukin‐6 (IL‐6) and rheumatoid factor (RF) positivity.ConclusionsIn ERA, HBMD changes were not associated with the appearance of erosions. Factors that associate in ERA with HBMD changes and appearance of erosions differ. HBMD assessment together with serum IL‐6 level could be useful in everyday clinical practice for better surveillance of ERA patients who do not have EC in hand X‐rays.
Taking Time to Unwind
Authors: Atwood Stephen P. 
Published: July 2022

AbstractSummer has arrived, and the busy season of Display Week is in the rearview mirror. I'm writing this at a picnic table from our summer camp in the Berkshire mountains, where (for a little while) I can escape the demands and sounds of civilization. We have marginal internet and some radio reception, but mostly the background soundtrack is birds and breezes in the trees.
An application of a fuzzy system for solving time delay fractional optimal control problems with Atangana–Baleanu derivative
Authors: Mortezaee Marzieh , Ghovatmand Mehdi , Nazemi Alireza 
Published: July 2022

AbstractIn this article, a new approach based on fuzzy systems is used for solving time delay fractional order optimal control problems. The fractional derivatives are considered in the Atangana–Baleanu sense that is a new derivative with the nonsingular and nonlocal kernel. By means of the calculus of variations and the formula for fractional integration by parts, the necessary optimality conditions associated to the time delay problem is derived. In order to solve the obtained optimality system, the solution of the system is first approximated by fuzzy solutions with adjustable parameters. The optimality system is then reduced to an unconstrained optimization problem by using appropriate error function. A learning algorithm is also presented to achieve the parameters of these fuzzy solutions. The efficiency and accuracy of the proposed approach are assessed through some illustrative examples of the time delay fractional optimal control problems.
An open‐source image classifier for characterizing recreational activities across landscapes
Authors: Winder Samantha G. , Lee Heera , Seo Bumsuk , Lia Emilia H. , Wood Spencer A. 
Published: July 2022

AbstractEnvironmental management increasingly relies on information about ecosystem services for decision‐making. Compared with regulating and provisioning services, cultural ecosystem services (CES) are particularly challenging to characterize and measure at management‐relevant spatial scales, which has hindered their consideration in practice.Social media are one source of spatially explicit data on where environments support various types of CES, including physical activity. As tools for automating social media content analysis with artificial intelligence (AI) become more commonplace, studies are promoting the potential for AI and social media to provide new insights into CES. Few studies, however, have evaluated what biases are inherent to this approach and whether it is truly reproducible.This study introduces and applies a novel and open‐source convolutional neural network model that uses computer vision to recognize recreational activities in the content of photographs shared as social media. We train a model to recognize 12 common recreational activities to map one aspect of recreation in a national forest in Washington, USA, based on images uploaded to Flickr.The image classifier performs well, overall, but varies by activity type. The model, which is trained with data from one region, performs nearly as well in a novel region of the same national forest, suggesting that it is broadly applicable across similar public lands. By comparing the results from our CNN model with an on‐site survey, we find that there are apparent biases in which activities visitors choose to photograph and post to social media.After considering potential issues with underlying data and models, we map activity diversity and find that natural features (such as rivers, lakes and higher elevations) and some built infrastructure (campgrounds, trails, roads) support a greater diversity of activities in this region.We make our model and training weights available in open‐source software, to facilitate reproducibility and further model development by researchers who seek to understand recreational values at management‐relevant scales—and more broadly provide an example of how to build, test and apply AI to understand recreation and other types of CESs.Read the freePlain Language Summaryfor this article on the Journal blog.
Experimental investigation on mechanical properties and free vibration characteristics of epoxy‐based glass/flax laminates
Authors: Ganesan Gnanakumar , Muthunadar Selvaraj , Ramasamy Murugan 
Published: July 2022

AbstractIn the present study, an attempt is made to replace the synthetic glass fiber used in the FRP structures in terms of natural flax fibers without much sacrifice on static and dynamic stability of the structure. Three types of glass/flax hybrid composite laminates were prepared with different fiber volume fraction of glass and flax fibers. For better understanding purpose, a dedicated glass and dedicated flax laminates were also fabricated. All the laminates were fabricated by vacuum bag molding method with uniform laminate thickness. The mechanical properties of the fabricated laminates, such as tensile strength and flexural strength, were evaluated in accordance with ASTM standards. The impulse excitation technique was used to assess the free vibration characteristics of glass/flax laminates such as modal frequency and material damping. Based on experimentally evaluated mechanical and vibration characteristics a suitable fiber volume fraction for the preferred laminate thickness was suggested to achieve optimum static and dynamic stability.
A surface modification of polylactic acid composites for additive manufacturing with modified chopped carbon fiber and modified nano‐hydroxyapatite
Authors: Wang Yanqing , Wang Xin , Xie Minghui , Zhou Zheng , Xu Huan 
Published: July 2022

AbstractPolylactic acid (PLA) composites parts obtained by fused deposition modeling (FDM) three‐dimensional (3D) printing have obvious fusion interfaces. The printed parts have low strength and poor plastic toughness, limiting their application in clinical degradable load‐bearing implants. In this article, first, the nano‐hydroxyapatite (n‐HA) was modified by PLA to obtain a core‐shell structure with PLA coating. The micron chopped carbon fiber (CF) was modified by nitric acid to obtain a rich oxygen‐containing functional group structure. Second, the above two modified materials of n‐HA and CF were coated on the surface of the PLA filament by ultrasonic impregnation to obtain the PLA/n‐HA/CF composite filament. Finally, tensile samples were manufactured by FDM 3D printing with the PLA/n‐HA/CF composite filament, and the tensile test was conducted. The results show that the surface‐modified n‐HA particles form a regular spherical core‐shell structure with good dispersibility. It can be combined with a matrix of PLA filament by the PLA coating layer, while a silane coupling agent combines the PLA coating layer and the core of n‐HA. The modified chopped CF treated with 68% nitric acid for 6 h has an ideal etch pits with moderate depth and distribution producing firm combination with the PLA matrix. The surface of modified chopped CF has abundant –COOH and –OH functional groups. It can be combined with a matrix of PLA filament through an esterification reaction. Among all the tensile samples, PLA_5% n‐HA_6% CF, with 5% modified n‐HA and 6% modified chopped CF, respectively, improves the bonding strength between the fused interfaces with the two reinforcement materials well‐distributed in the fuse interface area.