bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review of nutritional approaches to fibromyalgia
Authors: Kadayifci Fatma Z , Bradley Madelyn J , Onat Ahmet M , Shi Hai Ning , Zheng Shasha 
Published: April 2022

Abstract

Context
A multidisciplinary approach has been suggested to be the optimal form of treatment of fibromyalgia (FM). A research focus on nutritional therapy has developed in recent years, and this approach has been more frequently integrated into the recovery plan of patients with FM.

Objectives
The interaction between the nutritional status and health of patients with FM is highlighted in this review, and possible dietary approaches to ameliorating the disease’s effects are discussed.

Data sources
FM research studies containing a nutrition or diet focus with a publication date between 2000 and 2021 were scanned broadly through a computerized search of the MEDLINE, PubMed, and Web of Science databases.

Study selection
Studies that included the following criteria were eligible for inclusion: (1) original research and case studies that evaluated obesity and nutritional approaches as a therapeutic intervention for FM, and (2) patients older than 18 years who were diagnosed withFM according to the 1990 American College of Rheumatology criteria.

Data Extraction
Interventions included nutritional supplementation, nutrient- and obesity-related blood analyses, prescribed diets, body mass index or obesity and quality-of-life assessments, weight reduction, food-additive elimination, and evaluation of food perception and food sensitivity.

Results
After the literature search, 36 studies (N = 5142 individuals) were identified as relevant, and their full texts were assessed for inclusion in the review. Conditions such as obesity, food allergies, nutritional deficiencies, and food additives were revealed to be risk factors that correlated with complications of FM. Several studies showed beneficial effects for patients with FM of high-antioxidant, high-fiber foods such as fruits and vegetables, low processed foods, high-quality proteins, and healthy fats.

Conclusion
There is no specific diet therapy for the treatment of FM. However, overall, studies indicated that weight control, modified high-antioxidant diets, and nutritional supplementation are beneficial in alleviating symptoms in patients with FM.
Impact of Endoscopic Surgical Skill Qualification on Laparoscopic Resections for Rectal Cancer in Japan: The EnSSURE Study
Authors: Ichikawa Nobuki , Homma Shigenori , Hida Koya , Akagi Tomonori , Kamada Yasuyuki , Yamaguchi Tomohiro , Ito Masaaki , Ishida Fumio , Watanabe Jun , Yamamoto Daisuke , Iijima Hiroaki , Yamaguchi Shigeki , Inomata Masafumi , Sakai Yoshiharu , Naitoh Takeshi , Taketomi Akinobu ,   EnSSURE study group collaboratives in Japan Society of Laparoscopic Colorectal Surgery
Published: April 2022

Objective:
This cohort study investigated short- and long-term postoperative outcomes of laparoscopic procedures for rectal cancer performed with versus without certified surgeons.

Background:
In Japan, the Endoscopic Surgical Skill Qualification System (ESSQS) evaluates surgical skills deemed essential for laparoscopic surgery; however, it is unknown whether this certification contributes to procedural safety.

Methods:
Outcomes of laparoscopic rectal resections for cStage II and III rectal cancer performed from 2014 to 2016 at 56 Japanese hospitals were retrospectively reviewed. The impact of having versus not having certified surgeons on postoperative complications and other short- and long-term outcomes were assessed. In cases with ESSQS-certified surgeons, surgeons attended surgery in the capacity of an operator, assistant, scope operator, or advisor.

Results:
Overall, 3188 procedures were analyzed, with 2644 procedures performed with and 544 without ESSQS-certified surgeons. A multivariate logistic regression model showed that the adjusted odds ratio of postoperative complications after procedures performed with ESSQS-certified surgeons was 0.68 (95% confidence interval, 0.51–0.91; P = 0.009). The adjusted odds ratios for conversion and pathological R0 resection rates with ESSQS-certified surgeons were 0.20 (P < 0.001) and 2.10 (P = 0.04), respectively. Multiple linear regression analyses showed significantly shorter surgical duration and more harvested lymph nodes for operations performed with ESSQS-certified surgeons. Multivariate Cox regression showed that the adjusted hazard ratios for poor overall and recurrence-free survival after operations performed with ESSQS-certified surgeons were 0.88 (P = 0.35) and 1.04 (P = 0.71), respectively.

Conclusions:
This study showed the superiority of the short-term postoperative results for laparoscopic rectal procedures performed with ESSQS-certified surgeons.
Effect of Body Mass Index on Femur Fracture Location: A Retrospective Database Study
Authors: Manirajan Aaditya , Seidel Henry , Bhattacharjee Sarah , Dillman Daryl , Shi Lewis , Strelzow Jason 
Published: April 2022

Objectives:
Use a large database design and multivariable analyses to assess the associations between body mass index (BMI) and femur fracture patterns after controlling for other risk factors.

Design:
Retrospective cohort study.

Setting:
National insurance claims database of patient records from 2010 to 2018.

Patients/Participants:
Patients with femur fracture diagnoses were identified. Patients with multiple fractures within 1 week (polytrauma patients), patients without a BMI diagnosis code within 6 months of fracture, and patients with multiple BMI diagnosis codes (implying a substantial change in weight) were excluded.

Intervention:
N/A.

Main Outcome Measurements:
Patients were divided into groups based on fracture location: proximal (OTA/AO 31), shaft (OTA/AO 32), or distal (OTA/AO 33). The distribution of femur fractures was compared across BMI categories.

Results:
A total of 57,042 patients with femur fracture were identified: 45,586 proximal fractures, 4216 shaft fractures, and 7240 distal fractures. Patients with BMI <29.9 have increased odds (P < 0.0001) of proximal fracture and decreased odds (P < 0.0001) of shaft or distal fractures. Patients with BMI >30.0 have decreased odds (P < 0.0001) of proximal fracture and increased odds (P < 0.0001) of distal fractures.

Conclusions:
Increasing BMI is associated with a decreased proportion of proximal femur fractures and a corresponding increase in the proportion of shaft and distal fractures. Regression analyses determined that age, sex, osteoporosis, diabetes, and tobacco use are not the cause of this trend.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Prenatal exposure to multiple organochlorine compounds and childhood body mass index
Authors: Colicino Elena , Margetaki Katerina , Valvi Damaskini , Pedretti Nicolo Foppa , Stratakis Nikos , Vafeiadi Marina , Roumeliotaki Theano , Kyrtopoulos Soterios A. , Kiviranta Hannu , Stephanou Euripides G. , Kogevinas Manolis , McConnell Rob , Berhane Kiros T. , Chatzi Leda , Conti David V. 
Published: April 2022

Background:
Prenatal exposure to organochlorine compounds (OCs) has been associated with increased childhood body mass index (BMI); however, only a few studies have focused on longitudinal BMI trajectories, and none of them used multiple exposure mixture approaches.

Aim:
To determine the association between in-utero exposure to eight OCs and childhood BMI measures (BMI and BMI z-score) at 4 years and their yearly change across 4–12 years of age in 279 Rhea child-mother dyads.

Methods:
We applied three approaches: (1) linear mixed-effect regressions (LMR) to associate individual compounds with BMI measures; (2) Bayesian weighted quantile sum regressions (BWQSR) to provide an overall OC mixture association with BMI measures; and (3)Bayesian varying coefficient kernel machine regressions (BVCKMR) to model nonlinear and nonadditive associations.

Results:
In the LMR, yearly change of BMI measures was consistently associated with a quartile increase in hexachlorobenzene (HCB) (estimate [95% Confidence or Credible interval] BMI: 0.10 [0.06, 0.14]; BMI z-score: 0.02 [0.01, 0.04]). BWQSR results showed that a quartile increase in mixture concentrations was associated with yearly increase of BMI measures (BMI: 0.10 [0.01, 0.18]; BMI z-score: 0.03 [0.003, 0.06]). In the BVCKMR, a quartile increase in dichlorodiphenyldichloroethylene concentrations was associated with higher BMI measures at 4 years (BMI: 0.33 [0.24, 0.43]; BMI z-score: 0.19 [0.15, 0.24]); whereas a quartile increase in HCB and polychlorinated biphenyls (PCB)-118 levels was positively associated with BMI measures yearly change (BMI: HCB:0.10 [0.07, 0.13], PCB-118:0.08 [0.04, 012]; BMI z-score: HCB:0.03 [0.02, 0.05], PCB-118:0.02 [0.002,04]). BVCKMR suggested that PCBs had nonlinear relationships with BMI measures, and HCB interacted with other compounds.

Conclusions:
All analyses consistently demonstrated detrimental associations between prenatal OC exposures and childhood BMI measures.
Latent Neuropsychological Profiles to Discriminate Mild Traumatic Brain Injury and Posttraumatic Stress Disorder in Active-Duty Service Members
Authors: Esopenko Carrie , de Souza Nicola L. , Jia Yuane , Parrott J. Scott , Merkley Tricia L. , Dennis Emily L. , Hillary Frank G. , Velez Carmen , Cooper Douglas B. , Kennedy Jan , Lewis Jeffrey , York Gerald , Menefee Deleene S. , McCauley Stephen R. , Bowles Amy O. , Wilde Elisabeth A. , Tate David F. 
Published: April 2022

Objective:
To determine whether cognitive and psychological symptom profiles differentiate clinical diagnostic classifications (eg, history of mild traumatic brain injury [mTBI] and posttraumatic stress disorder [PTSD]) in military personnel.

Methods:
US Active-Duty Service Members (N = 209, 89% male) with a history of mTBI (n = 56), current PTSD (n = 23), combined mTBI + PTSD (n = 70), or orthopedic injury controls (n = 60) completed a neuropsychological battery assessing cognitive and psychological functioning. Latent profile analysis was performed to determine how neuropsychological outcomes of individuals clustered together. Diagnostic classifications (ie, mTBI, PTSD, mTBI + PTSD, and orthopedic injury controls) within each symptom profile were examined.

Results:
A 5-profile model had the best fit. The profiles differentiated subgroups with high (34.0%) or normal (21.5%) cognitive and psychological functioning, cognitive symptoms (19.1%), psychological symptoms (15.3%), and combined cognitive and psychological symptoms (10.0%). The symptom profiles differentiated participants as would generally be expected. Participants with PTSD were mainly represented in the psychological symptom subgroup, while orthopedic injury controls were mainly represented in the high-functioning subgroup. Further, approximately 79% of participants with comorbid mTBI and PTSD were represented in a symptomatic group (∼24% = cognitive symptoms, ∼29% = psychological symptoms, and 26% = combined cognitive/psychological symptoms). Our results also showed that approximately 70% of military personnel with a history of mTBI were represented in the high- and normal-functioning groups.

Conclusions:
These results demonstrate both overlapping and heterogeneous symptom and performance profiles in military personnel with a history of mTBI, PTSD, and/or mTBI + PTSD. The overlapping profiles may underscore why these diagnoses are often difficult to diagnose and treat, but suggest that advanced statistical models may aid in identifying profiles representing symptom and cognitive performance impairments within patient groups and enable identification of more effective treatment targets.
Traumatic Brain Injury History Among Individuals Using Mental Health and Addictions Services: A Scoping Review
Authors: Davies Julia , Dinyarian Camellia , Wheeler Anne L. , Dale Craig M. , Cleverley Kristin 
Published: April 2022

Objective:
Traumatic brain injury (TBI) has been increasingly linked in population research to psychiatric problems as well as substance use and related harms, suggesting that individuals with TBI may also present more frequently to mental health and addictions (MHA) services. Little is known, however, about TBI history among MHA service users. The objectives of this review were to understand (i) the prevalence of TBI history among MHA service users; (ii) how TBI history is identified in MHA service settings; and (iii) predictors or outcomes of TBI that have been reported in MHA service users.

Methods:
A scoping review was conducted in accordance with PRISMA Scoping Review Extension guidelines. A search for relevant literature was conducted in MEDLINE, PsycINFO, SPORTDiscus, CINAHL, and Embase as well as various gray literature sources.

Results:
Twenty-eight relevant studies were identified. TBI was defined and operationalized heterogeneously between studies, and TBI history prevalence rates ranged considerably among the study samples. The included studies used varied methods to identify TBI history in MHA settings, such as clinical chart audits, single-item questions, or structured questionnaires (eg, Brain Injury Screening Questionnaire or Ohio State University TBI Identification Method). TBI history was most consistently associated with indicators of more severe substance use problems and mental health symptoms as well as increased aggression or risk to others. Studies reported less consistent findings regarding the relationship of TBI to physical health, cognitive impairment, functioning, risk to self, and type of psychiatric diagnosis.

Conclusion:
Screening for TBI history in MHA settings may contribute important information for risk assessment and care planning. However, to be clinically useful, assessment of TBI history will require consistent operationalization of TBI as well as use of validated screening methods.
The Association Between Payer Source and Traumatic Brain Injury Rehabilitation Outcomes: A TBI Model Systems Study
Authors: Lequerica Anthony H. , Sander Angelle M. , Pappadis Monique R. , Ketchum Jessica M. , Jaross Marissa , Kolakowsky-Hayner Stephanie , Rabinowitz Amanda , Callender Librada , Smith Michelle 
Published: April 2022

Objective:
To examine the relationship between payer source for acute rehabilitation, residential median household income (MHI), and outcomes at rehabilitation discharge after traumatic brain injury (TBI).

Setting:
Acute inpatient rehabilitation facilities.

Participants:
In total, 8558 individuals enrolled in the Traumatic Brain Injury Model Systems (TBIMS) National Database who were admitted to inpatient rehabilitation between 2006 and 2019 and were younger than 64 years.

Design:
Secondary data analysis from a multicenter longitudinal cohort study.

Main Measures:
Payer source was divided into 4 categories: uninsured, public insurance, private insurance, and workers' compensation/auto. Relationships between payer source with residential MHI, rehabilitation length of stay (RLOS), and the FIM Instrument at discharge were examined. Covariates included age, injury severity, FIM at admission, and a number of sociodemographic characteristics including minority status, preinjury limitations, education level, and employment status.

Results:
Individuals with workers' compensation/auto or private insurance had longer RLOS than uninsured individuals or those with public insurance after controlling for demographics and injury characteristics. An adjusted model controlling for demographics and injury characteristics showed a significant main effect of payer source on FIM scores at discharge, with the highest scores noted among those with workers' compensation/auto insurance. The main effect of payer source on FIM at discharge became nonsignificant after RLOS was added to the model as a covariate, suggesting a mediating effect of RLOS.

Conclusion:
Payer source was associated with preinjury residential MHI and predicted RLOS. While prior studies have demonstrated the effect of payer source on long-term outcomes due to lack of inpatient rehabilitation or quality follow-up care, this study demonstrated that individuals with TBI who are uninsured or have public insurance may be at risk for poorer functional status at the point of rehabilitation discharge than those with private insurance, particularly compared with those with workers' compensation/auto insurance. This effect may be largely driven by having a shorter length of stay in acute rehabilitation.
Clinicopathological features and management of colonic lipomas
Authors: Erginoz Ergin , Uludag Server Sezgin , Cavus Gokce Hande , Zengin Kagan , Ozcelik Mehmet Faik 
Published: April 2022

Abstract

Introduction:
Colonic lipomas are benign tumors of adipose tissue that are often asymptomatic, but they may present with rectal bleeding or obstructive symptoms. These tumors are unique in that they are rarely encountered within the gastrointestinal system and can mimic malignant tumors in appearance. Surgical resection and endoscopic removal of tumors have been shown to be successful in their management.

Patient concerns:
In this report, we present 3 cases of colonic lipomas, 2 of which are located in the cecum and the other within the sigmoid colon. The presenting symptoms of the patients included abdominal pain, constipation, and dyspepsia.

Diagnosis:
Patients typically presented with anemia and an elevated C-reactive protein count. Colonoscopic and computerized tomography findings were used for diagnosis.

Interventions:
Hemicolectomy was performed, depending on the localization, and the pathologic specimens were consistent with lipoma.

Outcomes:
Surgical resection was curative in all patients. The postoperative period was uneventful in all patients and all patients are symptom-free and alive at 3 years follow-up.

Conclusion:
Colonic lipomas are benign mesenchymal tumors of the gastrointestinal system with a male predominance and are observed within the fourth to sixth decades of life. Various genetic abnormalities have been reported and they have been linked to the formation of intussusception. The squeeze sign on radiological imaging, cushion sign and tenting sign in colonoscopy, and naked fat sign during pathologic examination is helpful towards reaching a diagnosis. Surgical resection is the treatment of choice but minimally invasive endoscopic approaches have also been shown to be successful.
Minimally invasive pedicle screw fixation, including the fractured vertebra, combined with percutaneous vertebroplasty for treatment of acute thoracolumbar osteoporotic compression fracture in middle-age and elderly individuals
Authors: Liu Hong , Xu Jin-wei , Sun Guan-Rong , Shi Wei-Feng , Xiang Li-Ming , Chen Shan 
Published: April 2022

Abstract
To evaluate the feasibility, efficacy, and safety of minimally invasive pedicle screw (MIPS) fixation, including the fractured vertebra, combined with percutaneous vertebroplasty (PVP) for the treatment of acute thoracolumbar osteoporotic compression fracture in middle-age and elderly individuals.
Between January 2016 and August 2019, a total of 30 patients, with a mean age of 69.4 years (range, 58–75 years), who experienced thoracic or lumbar fracture without neurological deficits, underwent the MIPS procedure combined with PVP. Preoperative and postoperative pain were assessed using a visual analog scale and Oswestry Disability Index. Cobb angles and anterior column height were measured on lateral radiographs before surgery and at 3 days, 1, 3, and 6 months, and 1 and 2 years at final follow-up after surgery.
All patients underwent surgery successfully, with a mean follow-up of 18.2 ± 5.7 months (range, 12–45 months). Mean preoperative visual analog scale score decreased from 7.3 ± 2.2 to 1.4 ± 0.3 at the final follow-up (P < .05). Mean preoperative Oswestry Disability Index decreased from 84.2 ± 10.3 to 18.8 ± 7.5 (P < .05) at the final follow-up. The Kyphosis angle of operative segment was improved from preoperative (21.38 ± 1.68)° to (4.01 ± 1.38)° 3 days postoperatively and (5.02 ± 1.09)° at final follow-up (P < .05). The anterior vertebral height was improved from preoperative (49.86 ± 6.50)% to (94.01 ± 1.79)% 3 days postoperatively and (91.80 ± 1.88)% at final follow-up (P < .05). No significant changes in vertebral body height restoration were observed during 2 years of follow-up after surgery. In addition, there were no instrumentation failures or complications in any of the patients.
MIPS, including the fractured vertebra, combined with PVP, was a reliable and safe procedure, with satisfactory clinical and radiological results for the treatment of thoracolumbar osteoporotic compression fracture in patients without neurological deficits.
Traumatic trigeminal neuropathy after whiplash injury
Authors: Jang Sung Ho , Seo Jeong Pyo , Kwon Young Hyeon 
Published: April 2022

Abstract

Rationale:
Many studies using diffusion tensor tractography (DTT) have reported trigeminal neuropathy in various neurological diseases. However, no study on traumatic trigeminal neuropathy following whiplash has been reported.

Patient concerns:
A 51-year old female suffered an indirect head trauma resulting from a flexion-hyperextension injury. At approximately 30 minutes after onset, she began to sense a headache in the left frontal area and sensory changes in the left facial area, signs that intensified with the passage of time. At 7 days after onset, she visited the rehabilitation department of our university hospital and described the characteristics and severity of pain as follows: headache on the left frontal area including the forehead with intermittent squeezing and numbness sensations. Her visual analog scale pain score was 6 with her left cheek having a continuous, dull, swelling sensation (visual analog scale score: 1). On neurological examination, she revealed mild allodynia without hyperalgesia or somatosensory change on the head, cheek, tongue, and oral cavity.

Diagnosis:
Diffusion tensor imaging data were acquired 7 days after onset. On DTT, the left trigeminal nerve showed discontinuation in the middle portion compared to that of the right trigeminal nerve. Traumatic trigeminal neuropathy was diagnosed based on her clinical features and DTT findings.

Intervention:
She was prescribed carbamazepine (200 mg/day) and pregabalin (150 mg/day), and her facial pain was well-controlled to a tolerable level.

Outcomes:
These drugs were stopped after approximately 7 month's administration, however, she did not complain of facial pain.

Lessons:
By using DTT, we demonstrated traumatic trigeminal neuropathy in a patient with whiplash. We suggest that DTT would be a useful tool for detection of traumatic trigeminal neuropathy in patients who show clinical features of trigeminal neuropathy following whiplash.