bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective Comparison of Hypofractionated Versus Normofractionated Intensity-Modulated Radiotherapy in Breast Cancer: Late Toxicity Results of the Non-Inferiority KOSIMA Trial (ARO2010-3)
Authors: Sarria Gustavo R. , Welzel Grit , Polednik Martin , Wenz Frederik , Abo-Madyan Yasser 
Published: May 2022

PurposeTo compare the late toxicity profile of hypofractionation and normofractionation for whole-breast radiotherapy in breast cancer (BC) patients after conserving surgery.MethodsSixty-year-old or older patients with pTis-pT3, pN0-pN1a, M0 BC were recruited and stratified to hypofractionated (arm R-HF) or normofractionated (arm L-NF) intensity-modulated radiotherapy (IMRT), for right- and left-sided BC, respectively, in this single-center, non-randomized, non-inferiority trial. A boost was allowed if indicated. The primary outcome was the cumulative percentage of patients developing grade III fibrosis, grade I telangiectasia, and/or grade II hyperpigmentation after 2 years, with a pre-specified non-inferiority margin of 15% increase from an expected 2-year toxicity rate of 20%.ResultsThe Median follow-up was 4.93 (0.57–8.65) years for R-HF and 5.02 (0.65–8.72) years for L-NF (p=0.236). The median age was 68 (60–83 and 60–80) years, respectively. In total, 226 patients were recruited (107 for R-HF and 119 for L-NF), with 100 and 117 patients suitable for assessment, respectively. A boost was delivered in 51% and 53% of each arm, respectively. Median PTV volumes were 1013.6 (273–2805) cm3 (R-HF) and 1058.28 (315–2709) cm3 (L-NF, p=0.591). The 2-year primary endpoint rate was 6.1% (95% CI 1.3-11.7, n=5 of 82) and 13.3% (95% CI 7-20.2, n=14 of 105), respectively (absolute difference -7.2%, one-sided 95% CI ∞ to -0.26, favoring R-HF). No local recurrence-free- or overall-survival differences were found.ConclusionIn this prospective non-randomized study, hypofractionation did not have higher toxicity than normofractionated whole-breast IMRT.
Inhibition of Spleen Tyrosine Kinase Restores Glucocorticoid Sensitivity to Improve Steroid-Resistant Asthma
Authors: Liu Qian , Hua Lijuan , Bao Chen , Kong Luxia , Hu Jiannan , Liu Chao , Li Ziling , Xu Shuyun , Liu Xiansheng 
Published: May 2022

Background: Regulation or restoration of therapeutic sensitivity to glucocorticoids is important in patients with steroid-resistant asthma. Spleen tyrosine kinase (Syk) is activated at high levels in asthma patients and mouse models, and small-molecule Syk inhibitors such as R406 show potent anti-inflammatory effects in the treatment of immune inflammatory diseases. Several downstream signaling molecules of Syk are involved in the glucocorticoid response, so we hypothesized that R406 could restore sensitivity to dexamethasone in severe steroid-resistant asthma.Objective: To discover the role of the Syk inhibitor R406 in glucocorticoid resistance in severe asthma.Methods: Steroid-resistant asthma models were induced by exposure of C57BL/6 mice to house dust mite (HDM) and β-glucan and by TNF-α administration to the bronchial epithelial cell line BEAS-2B. We evaluated the role of the Syk inhibitor R406 in dexamethasone (Dex)-insensitive airway inflammation. Pathological alterations and cytokines in the lung tissues and inflammatory cells in BALF were assessed. We examined the effects of Dex or R406 alone and in combination on the phosphorylation of MAPKs, glucocorticoid receptor (GR) and Syk, as well as the transactivation and transrepression induced by Dex in mouse lung tissues and BEAS-2B cells.Results: Exposure to HDM and β-glucan induced steroid-resistant airway inflammation. The Syk inhibitor R406 plus Dex significantly reduced airway inflammation compared with Dex alone. Additionally, TNF-α-induced IL-8 production in BEAS-2B cells was not completely inhibited by Dex, while R406 markedly promoted the anti-inflammatory effect of Dex. Compared with Dex alone, R406 enhanced Dex-mediated inhibition of the phosphorylation of MAPKs and GR-Ser226 induced by allergens or TNF-α in vivo and in vitro. Moreover, R406 also restored the impaired expression and nuclear translocation of GRα induced by TNF-α. Then, the activation of NF-κB and decreased HDAC2 activity in the asthmatic model were further regulated by R406, as well as the expression of GILZ.Conclusions: The Syk inhibitor R406 improves sensitivity to dexamethasone by modulating GR. This study provides a reference for the development of drugs to treat severe steroid-resistant asthma.
Measurement of Anomalous Forces From a Cooper-Pair Current in High-Tc Superconductors With Nano-Newton Precision
Authors: Tajmar M. , Neunzig O. , Kößling M. 
Published: May 2022

Does a supercurrent drag space-time or generate a gravitational field that can be measured in a laboratory environment? A number of theories suggest that space-time itself could be modeled as a superfluid, so a current of Cooper-pairs might couple to its surroundings differently compared to non-quantum matter. On the other hand, experiments appeared in the literature suggesting that a discharge through a high-Tcsuperconductor generates a force beam, which can be picked up by external sensors. We developed a unique facility to investigate if such a link exists with unprecedented accuracy. Instead of measuring with sensors far away from the superconductor, we built a very precise thrust balance that features a cryostat allowing to measure any anomalous force directly from the superconducting source. An onboard battery and a wireless-controllable power supply as well as strict coaxial current leads ensure that any magnetic interaction with its surroundings is below the measurement noise. Our tests were done for both BSCCO and YBCO superconductors with and without the presence of a magnetic field parallel to the current flow. No force was seen within our resolution of around 100 nN for currents up to 15 A. This puts strong limits on all proposed theories and experimental claims.
GNSS NLOS Signal Classification Based on Machine Learning and Pseudorange Residual Check
Authors: Ozeki Tomohiro , Kubo Nobuaki 
Published: May 2022

Global navigation satellite system (GNSS) positioning has recently garnered attention for autonomous driving, machine control, and construction sites. With the development of low-cost multi-GNSS receivers and the advent of new types of GNSS, such as Japan’s Quasi-Zenith Satellite System, the potential of GNSS positioning has increased. New types of GNSS directly increase the number of line-of-sight (LOS) signals in dense urban areas and improve positioning accuracy. However, GNSS receivers can observe both LOS and non-line-of-sight (NLOS) signals in dense urban areas, and more NLOS signals are observed under static conditions than under dynamic conditions. The classification of LOS and NLOS signals is important, and various methods have been proposed, such as C/N0, using three-dimensional maps, fish-eye view, and GNSS/inertial navigation system integration. Multipath detection based on machine learning has also been reported in recent years. In this study, we propose a method for detecting NLOS signals using a support vector machine (SVM) classifier modeled with unique features that are calculated by receiver independent exchange format-based information and GNSS pseudorange residual check. We found that using both the SVM classifier and GNSS pseudorange residual check effectively reduced the error due to NLOS signals. Several static tests were conducted near high-rise buildings that are likely to receive some NLOS signals in downtown Tokyo. For all static tests, the percentage of positioning errors within 10 m in the horizontal positioning error was improved by &gt;80% by detecting and eliminating satellites receiving NLOS signals.
Relevance between Proximal Humeral Migration and Rotator Cuff Tears
Authors: Zhang Yichong , Chen Jianhai , Ma Mingtai , Ju Jiabao , Jiang Baoguo , Zhang Peixun 
Published: May 2022

BackgroundProximal humeral migration is common in patients with rotator cuff tears. In this study, we aimed to evaluate the relevance between proximal humeral migration and some rotator cuff tear-related factors.MethodsA total of 75 patients with unilateral rotator cuff tears were retrospectively included from August 2016 to January 2018 who underwent magnetic resonance imaging and X-ray examinations before enrollment. We introduced the upward migration index (UMI) to stratify the patients into three groups, Group A: 1 &lt; UMI ≤ 1.3; Group B: 1.3 &lt; UMI ≤ 1.4; and Group C: UMI &gt; 1.4. Pearson correlation analysis and logistic regression analysis were used to evaluate the relationship between UMI and age, sex, body mass index, pain, fatty degeneration grade, tear size, and thickness of ruptured tendon. Then, the χ2 test and receiver operator characteristic curve were applied to measure the diagnostic value of UMI.ResultsThe average UMI was 1.34 ± 0.07, ranging from 1.16 to 1.48. For the Pearson correlation analysis, there was a negative correlation between UMI and tear size (R = −0.68, p &lt; 0.01), and also, there was a negative correlation between UMI and the visual analogue scale score (R = 0.342, p &lt; 0.01). What is more, there was a negative correlation between UMI and the fatty degeneration grade (R = −0.373, p &lt; 0.01). Ordinal multinomial logistic regression analysis indicated that tear size (β = −1.825, p &lt; 0.001) was the independent predictor of UMI, which was a risk factor for humeral upward migration. The cutoff points of UMI were 1.38 and 1.3 to determine tears and distinguish large tears from small ones.ConclusionsUMI is a good predictor for humeral upward migration, which is related to the tear size of posterosuperior cuff tears. When the UMI is &lt;1.3, a large tear should be alerted. Combining physical examination and X-ray is helpful for evaluating rotator cuff tears.
Experimental Optimization of Metal Foam Structural Parameters to Improve the Performance of Open-Cathode Proton Exchange Membrane Fuel Cell
Authors: Wang Zixuan , Fan Linhao , Wu Siyuan , Tongsh Chasen , Zhang Yanyi , Yang Zirong , Du Qing , Hao Dong , Zhou Feikun , Jiao Kui 
Published: May 2022

Using metal foam as a flow field structure is an attractive route to improve the performance of open-cathode PEMFC. Metal foam has shown great potential in improving the uniformity of reactants, but optimized structure parameters that can more effectively transfer gas and remove excess water are needed. Here we experimentally investigate the effect of metal foam structure parameters on cell performance using polarization curves, power density curves, and electrochemical impedance spectrum (EIS) measurements. By optimizing the pore density, thickness, and compression ratio of the metal foam, the performance of the fuel cell is improved by 49.8%, 42.1%, and 7.3%, respectively. The optimum structure value of metal foam is the pore density of 40 PPI, the thickness of 2.4 mm, and the compression ratio of 4:2.4. In this configuration, the cell could achieve a maximum power density of 0.485 W cm−2. The findings of this work are beneficial for the application of metal foams in open-cathode PEMFC.
Ensayos
Authors: Autores Varios 
Published: May 2022

Durante los días miércoles 25 y jueves 26 de agosto del 2021, se realizó la décimo cuarta versión del Encuentro Departamental de Semilleros de Investigación de la Red Regional de Semilleros de Investigación -RREDSI, Nodo Quindío.
En esta nueva versión, la Universidad del Quindío lideró la organización de este tradicional encuentro departamental, el cual acogió, de manera virtual, a estudiantes de todas las instituciones de educación del Departamento, entre las que se encuentran las universidades Remington, La Gran Colombia Armenia, Alexander von Humboldt, Corporación Universitaria Unificada Nacional de Educación Superior, Antonio Nariño, Institución Universitaria EAM y el SENA.
Un total de 9 trabajos de investigación socializados en la modalidad de ensayos, las cuales fueron resultado de la interacción con comunidades y el sector productivo a partir de sus proyectos de semilleros de investigación.
Proportion of Hemodialysis Treatments with High Ultrafiltration Rate and the Association with Mortality
Authors: Navarrete José E. , Rajabalan Ajai , Cobb Jason , Lea Janice P. 
Published: May 2022

Key Points

Episodes of hemodialysis (HD) with high ultrafiltration rates (>13 ml/kg per hour) occurred frequently in 1050 incident dialysis patients.Younger age, diabetes, heart failure, higher albumin, being a man, shorter treatment time, and lower weight were associated with high UFR.Increasing numbers of dialysis sessions with high ultrafiltration rates were associated with higher all-cause and cardiovascular mortality.

Background
Rapid fluid removal during hemodialysis has been associated with increased mortality. The limit of ultrafiltration rate (UFR) monitored by the Centers for Medicare & Medicaid Services is 13 ml/kg per hour. It is not clear if the proportion of treatments with high UFR is associated with higher mortality. We examined the association of proportion of dialysis treatments with high UFR and mortality in end stage kidney failure patients receiving hemodialysis.

Methods
This was a retrospective study of incident patients initiating hemodialysis between January 1, 2010, and December 31, 2019, at Emory dialysis centers. The proportion of treatments with high UFR (>13 ml/kg per hour) per patient was calculated using data from the initial 3 months of dialysis therapy. Patients were categorized on the basis of quartiles of proportion of dialysis sessions with high UFR. Risk of death and survival probabilities were calculated and compared for all quartiles.

Results
Of 1050 patients eligible, the median age was 59 years, 56% were men, and 91% were Black. The median UFR was 6.5 ml/kg per hour, and the proportion of sessions with high UFR was 5%. Thirty-one percent of patients never experienced high UFR. Being a man, younger age, shorter duration of hemodialysis sessions, lower weight, diabetic status, higher albumin, and history of heart failure were associated with a higher proportion of sessions with high UFR. Patients in the higher quartile (26% dialysis with high UFR, average UFR 9.8 ml/kg per hour, median survival of 5.6 years) had a higher risk of death (adjusted hazard ratio 1.54; 95% CI, 1.13 to 2.10) compared with those in the lower quartile (0% dialysis with high UFR, average UFR 4.7 ml/kg per hour, median survival 8.8 years).

Conclusions
Patients on hemodialysis who did not experience frequent episodes of elevated UFR during the first 3 months of their dialysis tenure had a significantly lower risk of death compared with patients with frequent episodes of high UFR.
Exacerbation of Racial Disparities in Living Donor Kidney Transplantation During the COVID-19 Pandemic
Authors: Singh Neeraj , Li Ruixin , Alhamad Tarek , Schnitzler Mark A. , Mannon Roslyn B. , Doshi Mona D. , Woodside Kenneth J. , Hippen Benjamin E. , Cooper Matthew , Snyder Jon , Axelrod David A. , Lentine Krista L. 
Published: May 2022

Key Points

The coronavirus disease 2019 (COVID-19) pandemic profoundly impacted transplant services, with a particularly strong impact on living donor kidney transplantation.The COVID-19 pandemic appears to have disproportionately impacted Black patients’ access to living donor kidney transplantation.As the pandemic evolves through surges and vaccine acceptance disparities persist, ongoing attention to transplant disparities is needed.
Pelatihan Pengemasan Rumput Laut Caulerpa Pasca Panen Pada Kelompok Pembudidaya Rumput Laut Caulerpa Organik Di Kabupaten Takalar
Authors: Darmawati Darmawati , Murni Murni , Andayaningsih Sri , Anwar Asni , Hamsah Hamsah , Malik Abdul 
Published: May 2022

Masyarakat di wilayah pesisir Desa Laikang Kecamatan Magrabombang Kabupaten Takalar memanfaatkan lahan tambak sebagai tempat budidaya rumput laut caulerpa. Sampai saat ini kelompok pembudidaya masih memiliki berbagai macam kendala untuk meningkatkan hasil panennya. Kendala utama yang sering dialami oleh kelompok pembudidaya rumput laut“Bahagia Bersama” adalah rendahnya tingkat pemahaman mengenai tehnik pengemasan dan penanganan pasca panen sehingga mempengaruhi masa simpan Caulerpa racemossa setelah dipanen. Salah satu upaya yang dilakukan untuk menyikapi masalah tersebut adalah menerapkan penggunaan metode dehidrasi dengan penggunaan kadar garam yang tinggi untuk memperpanjang masa simpan Caulerpa yang dapat dikonsumsi dalam bentuk segar. Metode pelaksanaan kegiatan dilakukan dengan menggunakan metode diskusi, koordinasi,penyuluhan, pelatihan dan pendampingan kepada mitra. Berdasarkan hasil kegiatan pengabdian kepada masyarakat yang dilaksanakan pada kelompok Bahagia Bersama, dapat disimpulkan bahwa selama ini kelompok petani rumput laut Bahagia Bersama menggunakan tehnik pengemasan Caulerpa sebelum dijual tanpa diolah terlebih dahulu, tanpa pemanfaatan teknologi tepat guna. Melalui kegiatan pelatihan ini, kelompok mitra menjadi mengetahui dan terampil menggunakan tehnik dehidrasi sebelum dijual, sehingga dapat memperpanjang masa simpan caulerpa. Saran yang diberikan dalam kegiatan ini adalah sebaiknya dilakukan pendampingan lanjutan terkait penggunaan pengemasan serta pelatihan manajemen usaha untuk meningkatkan kualitas sumberdaya manusia sebagai pengelola pada produksi Caulerpa organk di Desa Laikang,Kabupaten Takalar.
Manajemen Risiko Keselamatan Dan Kesehatan Kerja Pada Pembangunan Jembatan Warnaf Di Kabupaten Raja Ampat
Authors: Pagoray Gebion Lysje 
Published: May 2022

Pembangunan Jembatan Warnaf di Kabupaten Raja Ampat Provinsi Papua. Pembangunan Jembatan merupakan konstruksi yang sangat beresiko dalam hal kecelakaan kerja. Kondisi lingkungan, penggunaan peralatan dan metode pelaksanaan yang tidak akurat serta kurang teliti dapat mengakibatkan kecelakaan kerja. Untuk itu diperlukan penanganan terhadap risiko K3 (Keselamatan dan Kesehatan Kerja). Penelitian ini bertujuan Mengidentifikasi risiko K3 (Keselamatan dan Kesehatan Kerja) yang dapat terjadi pada kegiatan proyek Jembatan, Memberikan penilaian atas risiko-risiko K3 yang terjadi pada proyek jembatan, Memberikan penanganan/solusi dari risiko-risiko K3. Hasil Penelitian menunjukkan bahwa teridentifikasi teridentifikasi 37 variabel potensi risiko yaitu 3 risiko yang menempati peringkat kategori risiko Ekstrim, 6 risiko yang menempati peringkat kategori risiko Tinggi / High Risk, dan 28 risiko yang menempati peringkat risiko sedang/ Medium Risk. Potensi kecelakaan akibat Pemasangan Bekesting pada Pekerjaan Beton dan Pemasangan dan Penempatan pada pekerjaan Pemasangan Unit Pracetak adalah risiko paling Ekstrim yaitu 15 %.
The construction of the Warnaf Bridge in Raja Ampat Regency, West Papua Province. Bridge construction is a very risk construction in terms of work accidents. Environmental conditions, use of equipment and methods of implementation that are not accurate and less precise can result in work accidents. For this reason, it is necessary to handle K3 (Occupational Health and Safety) risks.This study aims to identify OHS risks (Occupational Health and Safety) that can occur in Bridge project activities, Provide an assessment of OHS risks that occur in bridge projects, Provide solution of OHS risks. The results showed that 37 potential risk variables were identified, namely 3 risks ranked in the Extreme risk category, 6 risks ranked in the High Risk category, and 28 risks ranked in the Medium Risk category. The potential for accidents due to Formwork Installation on Concrete Works and Installation and Placement on Precast Unit Installation work is the most extreme risk, which is 15%.
An Ultra-Scalable Blockchain Platform for Universal Asset Tokenization: Design and Implementation
Authors: Buldas Ahto , Draheim Dirk , Gault Mike , Laanoja Risto , Nagumo Takehiko , Saarepera Märt , Shah Syed Attique , Simm Joosep , Steiner Jamie , Tammet Tanel , Truu Ahto 
Published: May 2022

<p>Since its introduction with Bitcoin in 2009, blockchain technology has received tremendous attention by academia, industry, politics and media alike, in particular, through extended blockchain-based visions such as smart contracts, decentralized finance, and, most recently, Web3. The critical prerequisite for any such blockchain-based vision to be turned into reality is uncapped scalability. Furthermore, and equally important, blockchain technology needs to transcend the stage of specialized tokens into an adaptive, heterogeneous tokenization platform. In this paper, we explain the Alphabill family of technologies that addresses both unlimited scalability and unrestricted adaptivity. We deliver a sharded blockchain technology with unlimited scalability and performance, called KSI Cash, which is based on a new form of electronic money scheme, the bill scheme. We present performance tests of KSI Cash that we have conducted with the European Central Bank and a group of eight national central banks from the Eurosystem in order to assess the technological feasibility of a digital euro, showing the system operating with 100 million wallets and 15 thousand transactions per second (under simulation of realistic usage), having an estimated carbon footprint of 0.0001g CO2 per transaction (Bitcoin = 100 kg and more); furthermore, showing the system operating with up to 2 million payment orders per second, an equivalent of more than 300.000 transactions per second (in a laboratory setting with the central components of KSI Cash), scaling linearly in terms of the number of deployed shards. We explain, in detail, the key concepts that unlock this performance (i.e., the concepts of the bill money scheme). The results provide evidence that the scalability of our technology is unlimited in both permissioned and permissionless scenarios, resulting into the Alphabill Money technology. Next, we contribute the architecture of a universal tokenization platform that allows for universal asset tokenization, transfer and exchange as a global medium of exchange, called Alphabill platform. We reveal the crucial conceptual and technical contributions of the platform's architecture and their interplay, including the data structures of KSI Cash and Alphabill Money, the dust collection solution of Alphabill Money, and the atomic swap solution of the Alphabill platform.</p>
Rethinking the didactic-educational space: suggestions for promoting school inclusion
Authors: Galdieri Michela , Di Gennaro Diana Carmela 
Published: May 2022

The central role played by space within the educational field, considered as a prerequisite for action, redefines the didactic experience through the meanings of design and organization, implying a systemic relationship between teacher, learner and contexts. The aim of this paper is to reflect upon the meanings of space, spatiality, accessibility and the opportunity to prepare educational and didactic places in which the inclusion of each and every one can be promoted, including pupils with complex communication needs. Indeed, for those pupils the absence of language, a partial or not very functional use of language can represent a limitation to well-being, an obstacle to activity and an impediment to participation to school context.

Ripensare lo spazio didattico-educativo: suggestioni per promuovere l’inclusione scolastica.
Il ruolo centrale dello spazio in ambito educativo, inteso come presupposto dell’azione, riconfigura l’esperienza didattica nei significati di progettazione e di organizzazione, implicando una relazione sistemica tra docente, discente e ambiente. L’obiettivo di questo lavoro è di riflettere sui significati di spazio, spazialità, accessibilità e sull’opportunità di predisporre luoghi dell’educazione e della didattica nei quali favorire l’inclusione di tutti e di ciascuno, ivi compresi, gli alunni con bisogni comunicativi complessi (BCC) nei quali l’assenza del linguaggio, un uso parziale o poco funzionale può costituire una limitazione al benessere, un ostacolo all’attività e un impedimento alla partecipazione nel contesto scolastico.