bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rare pediatric tumors in Germany – not as rare as expected: a study based on data from the Bavarian Cancer Registry and the German Childhood Cancer Registry
Authors: Achajew Aisana , Brecht Ines B. , Radespiel-Tröger Martin , Meyer Martin , Metzler Markus , Bremensdorfer Claudia , Spix Claudia , Erdmann Friederike , Schneider Dominik T. , Abele Michael 
Published: April 2022

AbstractVery rare pediatric tumors (VRTs) pose a challenge for treating physicians as little is known about the best diagnostic assessment and therapeutic decision-making in these malignancies. A large proportion of these cancers occur in adolescence. Therefore, the established structures of pediatric oncology including cancer registration may partly be circumvented. This may lead to an underregistration in clinical cancer registries of yet unclear extent. The aim of this study is to increase the knowledge on the occurrence of VRTs in pediatric patients in Germany. Pseudonymized data of cases recorded in the Bavarian Cancer Registry (BCR) between 2002 and 2014 were retrieved. VRTs according to the definition of the European Cooperative Study Group for Pediatric Rare Tumors were identified using the ICD and ICD-O classification. The numbers of registered patients were compared to those reported to the German Childhood Cancer Registry (GCCR). 6.3% (n = 290) of all malignancies (n = 4615) in the age below 18 years were classified as VRTs. Median age at diagnosis was 15 years (range 0–17 years). The most common tumor types included malignant melanoma, skin carcinoma, and gonadal tumors. During the same period, 49 pediatric patients from Bavaria with matchable VRTs were reported to the GCCR, accounting for 17% of cases reported to the BCR.Conclusions: The frequency of VRTs in Germany is underestimated in the national GCCR. With this study, we present population-based data on the incidence of VRTs in Germany for the first time. In order to gain additional knowledge about these malignancies, registration of VRTs must be improved through enhanced data exchange between the GCCR, the public cancer registries, and the clinical Registry for Rare Pediatric Tumors (STEP).

What is Known:• Rare pediatric tumors pose a challenge for treating physicians as limited knowledge is available on these malignancies for diagnostic and therapeutic decision-making.• Little is known about the frequency of these rare tumors in pediatric patients.

What is New:• The frequency of rare pediatric tumors in Germany is distinctly underestimated in the German Childhood Cancer Registry.• We present population-based data on the incidence of these rare pediatric cancers for the first time.
Allergic airway inflammation induces upregulation of the expression of IL-23R by macrophages and not in CD3 + T cells and CD11c+F4/80− dendritic cells of the lung
Authors: Leitner Maximilian , Heck Sebastian , Nguyen Kenny , Nguyen Phu Quyen , Harfoush Shaza , Rosenkranz Eva , Bals Robert , Dinh Quoc Thai 
Published: April 2022

AbstractInterleukin 23 and the interleukin 23 receptor (IL-23-IL23R) are described as the major enhancing factors for Interleukin 17 (IL-17) in allergic airway inflammation. IL-17 is considered to induce neutrophilic inflammation in the lung, which is often observed in severe, steroid-resistant asthma-phenotypes. For that reason, understanding of IL-23 and IL-17 axis is very important for future therapy strategies, targeting neutrophil pathway of bronchial asthma.This study aimed to investigate the distribution and expression of IL-23R under physiological and inflammatory conditions. Therefore, a house dust mite (HDM) model of allergic airway inflammation was performed by treating mice with HDM intranasally. Immunofluorescence staining with panel of antibodies was performed in lung tissues to examine the macrophage, dendritic cell, and T cell subpopulations. The allergic airway inflammation was quantified by histopathological analysis, ELISA measurements, and airway function.HDM-treated mice exhibited a significant allergic airway inflammation including higher amounts of NE+ cells in lung parenchyma. We found only a small amount of IL-23R positives, out of total CD3+T cells, and no upregulation in HDM-treated animals. In contrast, the populations of F4/80+ macrophages and CD11c+F4/80− dendritic cells (DCs) with IL-23R expression were found to be higher. But HDM treatment leads to a significant increase of IL-23R+ macrophages, only. IL-23R was expressed by every examined macrophage subpopulation, whereas only Mϕ1 and hybrids between Mϕ1 and Mϕ2 phenotype and not Mϕ2 were found to upregulate IL-23R. Co-localization of IL-23R and IL-17 was only observed in F4/80+ macrophages, suggesting F4/80+ macrophages express IL-23R along with IL-17 in lung tissue.The study revealed that macrophages involving the IL-23 and IL-17 pathway may provide a potential interesting therapeutic target in neutrophilic bronchial asthma.
The changing face of head and neck cancer: are patients with human papillomavirus-positive disease at greater nutritional risk? A systematic review
Authors: Edwards Anna , Brown Teresa , Hughes Brett G. M. , Bauer Judy 
Published: April 2022

Abstract
Purpose
Human papillomavirus (HPV) is now the primary cause of oropharyngeal head and neck cancer (OPC) worldwide; yet limited research has examined the effect of HPV-positive status (OPC+) on nutrition outcomes. This study aims to determine the impact of HPV status on nutritional outcomes for adult patients with OPC undergoing any treatment modality.

Methods
A systematic literature review was conducted up to and including July 2021 of PubMed, Embase, CENTRAL, CINAHL, and Web of Science to identify studies conducted in adults (>18 years) with known OPC reporting on any outcome(s) related to nutrition, according to HPV status (OPC+ versus OPC−). Bias was assessed using QUIPS tool, with certainty of evidence assessed using GRADE system.

Results
Six studies (total n = 635) all at moderate-high risk of bias were included. Three studies reported on weight change (n = 255), three feeding tube dependency (n = 380), three feeding tube timing of placement (prophylactic or reactive) and/or utilisation (n = 255), two nutritional (energy and/or protein) intake (n = 230), and one nutritional status (n = 83). Patients with OPC+ may experience greater weight loss, may have higher utilisation of reactive feeding tubes (both GRADE low certainty, downgraded due to serious bias and imprecision), and may have lower feeding tube dependency rates (GRADE low certainty, downgraded due to serious bias and inconsistency) versus OPC− . It is uncertain whether nutritional intake and nutritional status differed between populations (GRADE very low certainty, downgraded due to serious bias and very serious imprecision).

Conclusion
Further, high-quality research is needed to understand optimal nutritional care practices for patients with OPC + to achieve positive health outcomes into survivorship.
Livestock displace European mouflon from optimal foraging sites
Authors: Brivio Francesca , Ciuti Simone , Pipia Anna , Grignolio Stefano , Apollonio Marco 
Published: April 2022

AbstractThe conflict between free-ranging livestock and wildlife is a serious conservation concern across rural communities worldwide. Livestock may affect wild herbivores via direct competition for resources due to spatial and diet overlap or via behavioural interference. It is imperative that we disentangle the effects of livestock on wildlife behaviour to obtain an empirical basis able to stir management and conservation decisions. Here, we studied the effect of livestock presence on the habitat selection in a free-ranging European mouflon (Ovis aries musimon) population in Sardinia, where the species is under strict protection. We collected spatial data on mouflon and livestock during two consecutive years to investigate whether the mouflon selection of key feeding grassland sites was negatively impacted by the livestock presence. We found that mouflon preferably selected grassland, and its selection significantly increased when grass was of better quality (greener). We showed that livestock presence led to the displacement of mouflon from such preferred feeding sites, an effect clearly exacerbated by livestock proximity. We indeed found that the selection of grassland by mouflon dropped significantly when the distance between livestock and mouflon was below ~ 650 m, providing a useful management threshold indication. Livestock presence in close proximity displaced mouflon to sub-optimal habitat, and its effects may have negative impact on the population dynamic of this species which is already characterized by low female productivity within harsh Mediterranean environment. Our results give clear management indications aimed at better managing livestock grazing within natural areas to ultimately improve wildlife conservation.
Simulation-based training as a continuous means of vascular surgical education—a roadmap
Authors: Siegl Gregor , Ott Thomas , Cohnert Tina 
Published: April 2022

Summary
Background
Simulation-based training has become an important part of the educational approach in many professions. Over the past decades it has slowly found recognition in the medical field and in surgery in particular. Research has clearly shown the advantages of learning and honing skills on simulators in safe environments, especially for junior doctors. For this purpose, a number of models and methods have been developed to enable open vascular surgery training.

Methods
Extensive research was performed for the development of simulation-based training for vascular surgery. Different types of models and techniques were investigated. Aspects of specific theoretical and practical means of education and training were considered. This initiated the development of a simulation center for open vascular surgery.

Results
Perfused simulators and necessary surgical instruments were acquired for open vascular surgery training at the Simulation Center of the Styrian state hospitals, located at the University Hospital, Graz Medical University, in Graz. A fully equipped mock operating room is available for simulation. In-house junior and senior doctors from the Department of Vascular Surgery have the monthly opportunity to perform simulation-based training. Courses for all state hospitals are planned twice per year.

Conclusion
Simulation-based training is a safe, efficient, and well-manageable possibility for improving the education of future experts in open vascular surgery. It can help hone simple skills such as suture techniques as well as prepare for complex surgical procedures. In time we hope to further integrate simulation-based training in the existing curriculum.
Simplification of genetic programs: a literature survey
Authors: Javed Noman , Gobet Fernand , Lane Peter 
Published: April 2022

AbstractGenetic programming (GP), a widely used evolutionary computing technique, suffers from bloat—the problem of excessive growth in individuals’ sizes. As a result, its ability to efficiently explore complex search spaces reduces. The resulting solutions are less robust and generalisable. Moreover, it is difficult to understand and explain models which contain bloat. This phenomenon is well researched, primarily from the angle of controlling bloat: instead, our focus in this paper is to review the literature from an explainability point of view, by looking at how simplification can make GP models more explainable by reducing their sizes. Simplification is a code editing technique whose primary purpose is to make GP models more explainable. However, it can offer bloat control as an additional benefit when implemented and applied with caution. Researchers have proposed several simplification techniques and adopted various strategies to implement them. We organise the literature along multiple axes to identify the relative strengths and weaknesses of simplification techniques and to identify emerging trends and areas for future exploration. We highlight design and integration challenges and propose several avenues for research. One of them is to consider simplification as a standalone operator, rather than an extension of the standard crossover or mutation operators. Its role is then more clearly complementary to other GP operators, and it can be integrated as an optional feature into an existing GP setup. Another proposed avenue is to explore the lack of utilisation of complexity measures in simplification. So far, size is the most discussed measure, with only two pieces of prior work pointing out the benefits of using time as a measure when controlling bloat.
The Process Linking Child-Invested Contingent Self-Esteem and Conditional Regard: The Roles of Maternal Anger and its Regulation
Authors: Steffgen Sarah Teresa , Otterpohl Nantje , Wessing Franziska , Schwinger Malte , Assor Avi , Kanat-Maymon Yaniv , Gueta Bat El , Stiensmeier-Pelster Joachim 
Published: April 2022

AbstractParents whose self-esteem is contingent on their children’s achievements tend to exert more control over their children by displaying decreased affection and regard after failure in school (parental academic conditional negative regard). The current study examined parental anger and dysregulated anger expression as possible mechanisms in the respective association. In total, 221 mothers reported their child-invested contingent self-esteem, habitual dysregulated anger expression, anticipated anger after child failure, and their explicit use of conditional negative regard; their 12- to 14-year-old adolescent children reported perceived conditional negative regard. The moderated mediation analysis revealed that anger after child failure partially mediated the effect of child-invested contingent self-esteem on maternal explicit use of conditional negative regard, which, in turn, predicted adolescents’ perception of conditional negative regard. The effect of anger was moderated by dysregulated anger expression, and anger was only positively related to conditional negative regard when expressed as medium- to highly-dysregulated. The results support our hypotheses and provide an explanation for parental application of conditional negative regard apart from socialization goals or a lack of knowledge about its suboptimal nature. Furthermore, our results underscore the importance of parents’ self-esteem concerns and strategies for anger regulation. We discuss the practical implications of an anger-driven, reactive type of conditional regard.
Development of two common dragonfly species with diverging occupancy trends
Authors: Hogreve Jolan , Suhling Frank 
Published: April 2022

Abstract
The two sibling and syntopic odonate species Sympetrum striolatum and Sympetrum vulgatum are common and widespread in Central Europe. While S. striolatum has strong positive population trends, declines of S. vulgatum are observed. The aim of this study was to identify possible drivers of these diverging trends. We presumed that differences in egg development may lead to differences in survival until hatching. First, eggs laid in non-permanent or shrinking waterbodies may suffer of increasing drought periods. Second, differences in developement may cause increased size-mediated intraguild predation, a common cause of reduced survival in odonate larvae. Egg development time and hatching rates were recorded of eleven egg clutches of S. vulgatum and ten clutches of S. striolatum under simulated drought vs. water and direct vs. delayed development treatments. Hatching rates were reduced under drought conditions, and particularly so in S. vulgatum. We did not observe obligate winter diapause in any of the egg clutches. But, S. vulgatum varied widely in development between clutches, while the eggs of S. striolatum developed much faster and hatched highly synchronously. This would provide S. striolatum with a temporal advantage that may lead to a size-advantage over most S. vulgatum. We also found that S. vulgatum grew faster. Faster larval growth would only compensate for those S. vulgatum with fast egg development. The current population trends may be partly attributed to lowered survival of S. vulgatum under drought and by phenological and, thus, size benefits of S. striolatum.

Implications for insect conservation
Our results show that population dynamics of two closely related dragonfly species can be explained by climatically induced changes in their interactions. Understanding the causes and processes of behavioural changes resulting in differing population trends is fundamental for the protection of species.
Inequalities in Tobacco Retailer Compliance Violations Across the State of Oklahoma, 2015–2019
Authors: Sedani Ami E. , Chen Sixia , Beetch Jessica E. , Martinez Sydney A. , Dao Hanh Dung N. , Campbell Janis E. 
Published: April 2022

Abstract
Objective
To evaluate the relationship between compliance check violations, and characteristics of the tobacco retailer and neighborhood social vulnerability in Oklahoma.

Design
This cross-sectional study utilized the US Food and Drug Administration (FDA) Compliance Check Inspections of Tobacco Product Retailers database for 2015–2019. These data were combined with Neighborhood social vulnerability variables using the Centers for Disease Control and Prevention (CDC) Social Vulnerability Index.

Setting
The setting of this study is the state of Oklahoma, USA.

Outcome measures
The outcome variable for this analysis was whether a sale was made to the youth during the compliance check (e.g., violation; yes/no) regardless of the outcome of the violation, and number of violations per a retailer.

Results
We observed a strong association between having a violation and retailer store type, after controlling for socioeconomic vulnerability and percentage of mobile homes. The proportion of a tobacco retailer’s violations also varied by store type.

Conclusions
More targeted enforcements and retailer education by store type may be necessary to increase compliance.
Reference publication year spectroscopy (RPYS) in practice: a software tutorial
Authors: Haunschild Robin , Bornmann Lutz 
Published: April 2022

AbstractIn course of the organization of Workshop III entitled “Cited References Analysis Using CRExplorer” at the International Conference of the International Society for Scientometrics and Informetrics (ISSI2021), we have prepared three reference publication year spectroscopy (RPYS) analyses: (i) papers published in Journal of Informetrics; (ii) papers regarding the topic altmetrics; and (iii) papers published by Ludo Waltman (we selected this researcher because he received the Derek de Solla Price Memorial Medal during the ISSI2021 conference). The first RPYS analysis has been presented live at the workshop and the second and third RPYS analyses have been left to the participants for undertaking after the workshop. Here, we present the results for all three RPYS analyses. The three analyses have shown quite different seminal papers with a few overlaps. Many of the foundational papers in the field of scientometrics (e.g., distributions of publications and citations, citation network and co-citation analyses, and citation analysis with the aim of impact measurement and research evaluation) were retrieved as seminal papers of the papers published in Journal of Informetrics. Mainly papers with discussions of the deficiencies of citation-based impact measurements and comparisons between altmetrics and citations were retrieved as seminal papers of the topic altmetrics. The RPYS analysis of the paper set published by Ludo Waltman mainly retrieved papers about network analyses, citation relations, and citation impact measurement.
Structuralism, indiscernibility, and physical computation
Authors: Doherty F. T. , Dewhurst J. 
Published: April 2022

AbstractStructuralism about mathematical objects and structuralist accounts of physical computation both face indeterminacy objections. For the former, the problem arises for cases such as the complex rootsiand$$-i$$-i, for which a (non-trivial) automorphism can be defined, thus establishing the structural identity of these importantly distinct mathematical objects (see e.g. Keränen in Philos Math 3:308–330, 2001). In the case of the latter, the problem arises for logical duals such as AND and OR, which have invertible structural profiles (see e.g. Shagrir in Mind 110(438):369–400, 2001). This makes their physical implementations indeterminate, in the sense that their structural profiles alone cannot establish whether a given physical component is an AND-gate or an OR-gate. Doherty (PhilPapers,https://philpapers.org/rec/DOHCI-3, 2021) has recently shown both problems to be analogous, and has argued that computational structuralism is threatened with the absurd conclusion that computationaldigitsmight be indiscernible, such that, if structural properties are all that we have to go on, the binary digit 0 must be treated as identical to the binary digit 1 (rendering pure structuralism absurd). However, we think that a solution to the indiscernibility problem for mathematical structuralists, drawing on the work of David Hilbert, can be adapted for the analogous problem in the computational case, thereby rescuing the structuralist approach to physical computation.
User-centred design of clinical dashboards for guided iCBT
Authors: Dugstad Wake Jo , Rabbi Fazle , Inal Yavuz , Nordgreen Tine 
Published: April 2022

AbstractAs Internet-based technology spreads to most areas of life, it becomes a challenge to grasp opportunities arising from enormous amounts of data being generated from various sources such as smart homes, smart cities, health care systems and industries. Efficient utilization of these data can enable us to improve many human practices, including those connected to health care. In the present study, we focus on the health care sector, as it consists of large-scale organizations that rely on the processing of big data and complex processing of information. Due to the dynamic nature and complexity of this domain, it is essential to develop sophisticated technologies for the efficient processing of vast amounts of information. There is, for example, a need for interactive tools that can visualise actual care processes being executed in the hospital. A tool visualising real-time data could give a dynamic view of the processes, with accurate quantitative information, which can be used to improve the quality and efficiency of health care provision. These tools should be built on the requirements of practitioners needs and requirements, to ensure their relevance and practical utility. In this paper, we present a user-driven design process for developing therapy data visualisation components of guided Internet-based cognitive behaviour therapy (iCBT) and their evaluation. In order to ensure the reusability of the visual components, we propose to utilise a model-based approach which allows data analysts to adapt domain models by means of model transformation and transform them into visualization.