bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three versus 12‐month dual antiplatelet therapy duration in patients with acute coronary syndrome undergoing percutaneous coronary intervention: A meta‐analysis of randomized controlled trials
Authors: Selvaraj Vijairam , Chatterjee Saurav , Hirai Taishi , Abbott J. Dawn , Bavishi Chirag 
Published: November 2022

AbstractIntroductionThe American Heart Association/American College of Cardiology guidelines on dual antiplatelet therapy (DAPT) recommend at least 12 months of a P2Y12 inhibitor and low dose aspirin in patients with an acute coronary syndrome (ACS) treated with a stent. Since that recommendation, several randomized controlled trials (RCTs) have studied an abbreviated duration of DAPT in ACS. Therefore, we sought to perform a meta‐analysis of RCTs comparing 3‐ versus 12‐month DAPT in patients presenting with ACS undergoing percutaneous coronary intervention (PCI).MethodsPubMed, Embase, and Cochrane Central databases were searched until July 31, 2022, for RCTs comparing 3‐ versus 12‐month DAPT in patients with ACS undergoing PCI. Outcomes assessed were major adverse cardiovascular events (MACE), cardiovascular mortality, all‐cause mortality, myocardial infarction (MI), stent thrombosis (ST) and bleeding. A random‐effects model was used to calculate pooled relative risk (RR) and 95% confidence intervals (CI).ResultsWe included 5 trials comprising 16,781 patients with an ACS that underwent PCI. There was no significant difference in MACE (RR: 0.92; 95% CI: 0.76–1.11), cardiovascular mortality (RR: 1.26; 95% CI: 0.38–4.17), or all‐cause mortality (RR: 0.92; 95% CI: 0.48–1.77) between the 2 groups. In addition, there was no difference in rates of MI (RR: 0.98; 95% CI: 0.74–1.30), or ST (RR: 1.30; 95% CI: 0.55–3.05) between 3‐ and 12‐month DAPT. However, compared with 12‐month DAPT, 3‐month DAPT significantly reduced risk of major bleeding (RR: 0.53; 95% CI: 0.43–0.64).ConclusionsIn patients with ACS undergoing PCI, 3‐month DAPT reduced risk of bleeding without evidence of harm.
Metal‐Ligand Cooperativity in MnI‐Catalysed N‐Formylation of Secondary Amides and Lactams Using CO2 at Room Temperature
Authors: Chakraborty Soumi , Nath Rounak , Kumar Ray Anuj , Paul Ankan , Mandal Swadhin K. 
Published: November 2022

AbstractA MnI catalyst featuring redox‐active tridentate phenalenyl (PLY) ligand has been used for catalytic N‐formylation of secondary amides and lactams under 1 atm CO2 as a C1 source at room temperature for the first time. The protocol is applicable to a wide range of secondary amides including heterocycles, bio‐active cinnamide derivatives and the diversification of therapeutic molecules. In‐depth mechanistic investigations based on experimental outcomes and DFT calculations suggested an unconventional metal‐ligand cooperation, where a ligand‐centred radical plays a crucial role in initiating the reaction process.
Comparative study on inhibitory performance of an ionic liquid on corrosion of 6061 Al‐10(vol.%) SiC(P) composite material and base alloy
Authors: Kedimar Namitha , Rao Padmalatha , Rao Suma A. 
Published: November 2022

AbstractInhibitive performance of 1,3 dimethyl imidazolium dimethyl phosphate (DIDP) towards the corrosion of 6061‐Al (10 vol.%) SiC(P) composite (Al‐CM) and base alloy in 0.1 M HCl medium was studied using electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization techniques at different temperatures. Optimization of inhibitor concentration was done to get maximum inhibition efficiency. Thermodynamic parameters were calculated by fitting the results into a suitable adsorption isotherm. Scanning electron microscope (SEM), energy‐dispersive X‐ray (EDX), and atomic force microscope (AFM) analyses were performed to understand surface morphology, elemental mapping, and surface roughness before and after the addition of DIDP. UV–visible and X‐ray diffraction (XRD) tests were performed to confirm the adsorption of inhibitor on the surfaces of materials. Studies revealed an increased rate of corrosion for Al‐CM than for the base alloy. The maximum inhibition efficiency for the base alloy was found to be 80.48% for the addition of 1000 ppm, and for Al‐CM, it was found to be 87.38% for the addition of 1400 ppm at 303 K. As the temperature increased, the inhibition efficiency decreased. The inhibitor was adsorbed physically on the surface of the metal by obeying the Freundlich adsorption isotherm. Surface studies confirmed the adsorption of DIDP on the surfaces of both Al‐CM and the base alloy.
Mobility prediction for uneven distribution of bikes in bike sharing systems
Authors: Shir Bhargav , Prakash Verma Jai , Bhattacharya Pronaya 
Published: November 2022

SummaryUser mobility represents the movement of either individual or group. In smart cities, detection and prediction of mobility patterns are required for numerous applications like resource distribution, traffic management, and user behavioral analysis. With the increase in the number of smart vehicles, urban mobility detection and prediction have become a critical problem for study. Bike‐sharing ecosystems (BSS) form an integral part of such ecosystems, as it supports the green revolution, ease of access, and solves traffic problems. However, recent schemes have suggested that BSS are challenged by issues of high density, mobility complexity of bikes (stations), large commute cost, uneven distribution, and route imbalances. To address the critical issues, the article proposes a hybrid scheme that combines rebalancing using clustering that addresses the mobility complexity. Once rebalancing is done, we address the uneven distribution among clusters using prediction models. This article is presented a comparative analysis of algorithms like fuzzy C‐means clustering, linear regression, decision tree, and random forest classifiers for predictive analysis performed on weather data and nonweather data. The presented results indicate the viability of the proposed model in real‐world scenarios.
An electric vehicle integrated battery charger with high utilization rate of the three‐phase open‐winding permanent‐magnet‐synchronous‐motor
Authors: Lei Yanxiong , Du Guiping , Li Tuhuan , Yang Zijiang 
Published: November 2022

AbstractThis paper proposes an integrated battery charger for electrical vehicles (EVs) employing a three‐phase open‐winding permanent magnet synchronous motor (3p OW‐PMSM), which can be simply modified from a typical star‐connected PMSM. It reutilizes the existing propulsion components to achieve fast charging and vehicle to grid (V2G) operations. Only one nonintegrated inductor is added to realize torque cancelation so that no rotation or vibration is generated. In the fast‐charging and the V2G modes, the current flowing through the inductor is half of one phase grid current, namely, one in six of the total grid currents. The rest five in six of the grid currents flow through the stator windings of the motor. Hence, the proposed integrated system has a high utilization rate of the motor and possesses high power density. In addition, an individual inner current controller for each leg of the AC‐DC converter is employed to ensure the unity power factor, low current harmonics, and torque elimination. In the motor‐drive mode, the equivalent circuit is consistent with the conventional 3p star‐connected motor driver. Therefore, it does not increase the complexity of the motor‐drive control strategy. Finally, simulation and experimental results for fast‐charging, V2G, and propulsion operations verify the feasibility of the proposed scheme.
Desalination using solar stills: A review
Authors: Shelake Amit , Kumbhar Dnyaneshwar , Sutar Kailasnath 
Published: November 2022

AbstractPurified drinking water is the basic need of human beings. Purification of water assisted by freely available solar energy can be the best alternative compared with other water purification techniques available in the market today which consume nonrenewable energy. Distillation, which is the most ancient method, is being used for water purification. The device in which solar thermal energy converts brackish water into pure drinkable form is known as a solar still. Present article reports an extensive study of numerous designs of solar stills. The article also includes a review of effect of each parameter that influences the water productivity that is, pure water. Considerations of thermodynamics, heat transfer, and mass transfer are also explained in brief. The reviews of various kinds of analysis namely, theoretical, experimental, computational, cost, and water quality have been reported.
CropBooster‐P: Towards a roadmap for plant research to future‐proof crops in Europe
Authors: Baekelandt Alexandra , Saltenis Vandasue L. R. , Pribil Mathias , Nacry Philippe , Harbinson Jeremy , Rolland Norbert , Wilhelm Ralf , Davies Jessica , Inzé Dirk , Parry Martin A. J. , Klein Lankhorst René 
Published: November 2022

AbstractThe world needs more than double its current agricultural productivity by 2050 to produce enough food and feed, as well as to provide feedstock for the bioeconomy. These future increases will not only need to be sustainable but without comprommising the nutritional quality, and ideally also need to decrease greenhouse gas emissions and increase carbon sequestration to help mitigate the consequences of global climate change. These challenges could be tackled by developing and integrating new future‐proof crops into our food system. The H2020 CropBooster‐P project sets out plant‐centered breeding approaches guided by a broad socio‐economic and societal support. First, the potential approaches for breeding crops with sustainably increased yields adapted to the future climate of Europe are identified. These crop‐breeding options are subsequently prioritized and their adoption considered by experts across the agri‐food system and the wider public, taking into account environmental, economic and other technical criteria. In this way, a specific research agenda to future‐proof our crops was developed, supported by an eventual implementation plan.
What can COVID‐19 pandemic reveal about public purpose of a University? A case study
Authors: Mohebali Milad 
Published: November 2022

AbstractThis case study examines institutional communication of purpose to stakeholders through Facebook during the COVID‐19 pandemic. The findings show that the institution attempted to reduce the negative impacts of the pandemic on campus life and student experiences while using the pandemic as an opportunity to re‐iterate the importance of its scientific knowledge production, training of professionals, and service to communities. In doing so, it established relationships with multiple publics at a time of crisis, but has run the risk of further losing public trust in science and university as the COVID‐19 pandemic has persisted.
A scoping review on the relationship between race/ethnicity and the receipt of supportive care medications during cancer treatment: Implications for the clinical pharmacist
Authors: Awunti MegCholack , DeRemer David L. , Rogers Sherise , Scarton Lisa , Adkins Lauren , WIlkie Diana J. , Allen John M. 
Published: November 2022

AbstractThere is surmounting levels of evidence on the health disparities within cancer treatment in the United States (US). Most of the research focused on cancer specific factors including anticancer incidence, screening, treatment and follow‐up, and clinical outcomes such as overall survival (OS). Less is known about the disparities present with supportive care medication use in cancer patients. Supportive care utilization during cancer treatment has been linked to improved quality of life (QoL) and OS among patients. The goal of this scoping review is to summarize findings of current literature on the relationship between race and ethnicity and the receipt of supportive care medications during cancer treatment for pain and chemotherapy‐induced nausea and vomiting (CINV). This scoping review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA‐ScR) guidelines. Our literature search included quantitative studies, qualitative studies, and grey literature written in the English language with clinically relevant outcomes pertaining to pain and CINV management in cancer treatment published from 2001 to 2021. Articles that met the predefined inclusion criteria were considered for inclusion in the analysis. The initial search yielded 308 studies. Following deduplication and screening, 14 studies met the predefined inclusion criteria, with majority of the studies being quantitative studies (n = 13). Collectively, results were mixed results regarding the presence of racial disparities for supportive care medication use. Half of the studies (n = 7) supported this finding whereas, the other half (n = 7) did not identify any racial disparities. In our review, multiple studies illustrate the existence of disparities in the use of supportive care medications in some cancer types. Clinical pharmacists should strive to eliminate supportive medication use disparities as part of a multidisciplinary team. In order to develop strategies to prevent supportive care medication use disparities in this population, further research and analysis of external factors that influence them are needed.
What compliance commitments tell us about U.S. banks?
Authors: Semenenko Igor 
Published: November 2022

AbstractThis paper examines three levels of regulation and compliance imposed by the Federal Reserve, the Securities and Exchange Commission (SEC), and stock exchanges, on risk profile of banking institutions in the United States. SEC‐registered and exchanged‐listed bank holding companies have more concentrated and lower quality loan portfolios; they grow faster through acquisitions and are more likely to execute M&A exit strategy themselves. Also, bank holding companies that commit to higher levels of compliance are better capitalized but have lower return on equity capital. Lower profitability is partially compensated with higher payout ratio, suggesting that regulatory frameworks to some extent ameliorate agency issues.Multi‐tiered regulation of banking institutions yields a separating equilibrium, in which banks choose level of compliance to match their business strategies. Three‐tiered regulatory framework enables market segmentation and matching of capital providers with desired risk profile. Switch to higher levels of compliance is accompanied by risk profile increase without a better risk‐return tradeoff, suggesting managerial agency cost explanation. SEC‐compliant banks are likely to migrate to exchanges or downshift to FDIC disclosure only. Both SEC and exchange‐listed banks are likely to execute growth‐by‐acquisitions but listed bank holding companies are only marginally more likely to default, suggesting more efficient risk‐taking or reliance on government support when market conditions decline. SEC compliance is the most volatile of three disclosure regimes.My study does not conclude that excessive regulation yields negative effects. It does not address assessment of changes in systematic risk and externalities focusing instead on firm‐level effects. Finally, it suggests the need to regulate the market for corporate control, which appears to be one major risk‐taking transmission mechanism in the US private banking market.
The performance of ANI‐ML potentials for ligand‐n(H2O) interaction energies and estimation of hydration free energies from end‐point MD simulations
Authors: Temel Mütesir , Tayfuroglu Omer , Kocak Abdulkadir 
Published: November 2022

AbstractHere, we investigate the performance of “Accurate NeurAl networK engINe for Molecular Energies” (ANI), trained on small organic compounds, on bulk systems including non‐covalent interactions and applicability to estimate solvation (hydration) free energies using the interaction between the ligand and explicit solvent (water) from single‐step MD simulations. The method is adopted from ANI using the Atomic Simulation Environment (ASE) and predicts the non‐covalent interaction energies at the accuracy of wb97x/6‐31G(d) level by a simple linear scaling for the conformations sampled by molecular dynamics (MD) simulations of ligand‐n(H2O) systems. For the first time, we test ANI potentials' abilities to reproduce solvation free energies using linear interaction energy (LIE) formulism by modifying the original LIE equation. Our results on ~250 different complexes show that the method can be accurate and have a correlation of R2 = 0.88–0.89 (MAE <1.0 kcal/mol) to the experimental solvation free energies, outperforming current end‐state methods. Moreover, it is competitive to other conventional free energy methods such as FEP and BAR with 15‐20 × fold reduced computational cost.
Female income generation and intimate partner violence: Evidence from a representative survey in Turkey
Authors: Kibris Arzu , Nelson Phillip 
Published: November 2022

AbstractEconomic empowerment of women is a central strategy to foster economic growth and reduce gendered discrimination. However, it is not yet certain whether the positive impacts extend into domestic violence as theoretical and empirical evidence indicate the possibility of unintentional adverse consequences. We present and analyse new survey data from Turkey. Our results indicate higher risk of intimate partner violence for income‐earning women and point to forced rent extraction by male partners as the mechanism. Organizations promoting such empowerment in development contexts should be aware of these potential negative consequences and should plan for steps to mitigate them.
Patients With “Gray Zone” PSA Levels: Application of Prostate MRI and MRS in the Diagnosis of Prostate Cancer
Authors: Li Xue , Li Chunmei , Chen Min 
Published: November 2022

Improving the detection rates of prostate cancer (PCa) and avoiding unnecessary prostate biopsies in men with prostate‐specific antigen (PSA) levels within the gray zone require urgent attention. In this context, rapid advances in MR technology in recent years may offer a promising possibility. A systematic review to evaluate the applications of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) in detecting PCa and clinically significant PCa (csPCa) in men with PSA levels within the gray zone. The study type is defined as systematic review. In July 2022, out of 229 studies identified by the database search and from other sources, 23 articles related to the selected topic of interest were included in this review. No field strength or sequence restrictions. The data including the study population, study characteristics, as well as basic MRI characteristics, from the final studies included in this review, were extracted independently by two reviewers. The major results of the original study were summarized and no additional statistical analysis was performed. Among the 23 studies included in this review, 17 focused on the applications of MRS and MRI for the prebiopsy diagnosis of PCa. Nine of these 17 articles used Prostate Imaging Reporting and Data System (PI‐RADS) score to interpret MRI results, thereby confirming the practicality of the PI‐RADS score in predicting PCa and csPCa. The remaining six articles evaluated the applications of MRI and MRS in guiding prostate biopsy. Although there was a variation in the biopsy modalities used in these studies, both MRI‐ and MRS‐guided prostate biopsies were observed to improve the detection rates of PCa and csPCa in patients with PSA levels within the gray zone. MRS and MRI showed good performance in the detection of PCa and csPCa before biopsy. In addition, MRS‐ or MRI‐guided prostate‐targeted biopsies were able to improve the detection rates of PCa and csPCa.Evidence Level3Technical EfficacyStage 2
Integrating Postradiotherapy MRI‐Detected Lymph Node Necrosis and Pre‐ and Posttreatment Epstein–Barr Virus‐DNA for Risk Stratification in Nasopharyngeal Carcinoma
Authors: Cao Di , Li Shaolong , Li Haojiang , Liu Lizhi , Wang Xiaoyi , Quan Tingting 
Published: November 2022

BackgroundResidual lymphadenopathy and detectable Epstein–Barr virus (EBV) DNA after radiotherapy (RT) are known negative prognostic factors for nasopharyngeal carcinoma (NPC). However, there is a need to distinguish between patients with residual disease that will metastasize and those who will not.PurposeTo develop a prognostic model to improve the risk stratification of NPC patients after RT.Study TypeRetrospective.PopulationThree hundred eighty‐seven NPC patients treated with RT between January 2010 and January 2013.Field Strength/SequenceT1‐, T2‐weighted and enhanced T1‐weighted imaging at 1.5 or 3.0 T pretreatment and 3–4 months post‐RT.AssessmentPost‐RT central nodal necrosis (CNN) and other nodal characteristics on MRI were assessed by three radiologists independently. EBV DNA was measured by quantitative polymerase chain reaction. The association between these variables and the primary endpoint (5‐year distant metastasis‐free survival [DMFS], time from the day of diagnosis to any distant metastasis) was analyzed. Nomograms A (pre‐/posttreatment EBV‐DNA + N stage + post‐RT retropharyngeal lymph node [RLN] CNN), B (tumor‐node‐metastasis [TNM] stage + pretreatment EBV‐DNA), and C (TNM stage + post‐RT EBV‐DNA) were developed.Statistical TestsUnivariate and multivariate analyses were performed with the Cox regression model. Nomograms were developed based on the Cox regression model and two prognostic models. The concordance index (C‐index) and calibration curve were used to evaluate the discriminative ability of the nomograms and TNM stage. P‐values < 0.05 were considered statistically significant.ResultsPost‐RT RLN CNN was an independent prognostic factor for 5‐year DMFS (hazard ratio, 2.88 [1.48–5.62]). Nomogram A (C‐index 0.728 [0.660–0.797]) demonstrated better risk discrimination than nomogram B (0.638 [0.571–0.705]), nomogram C (0.707 [0.636–0.778]), and the TNM stage (0.587 [0.515–0.659]) for 5‐year DMFS in NPC.Data ConclusionNomogram A combining pretreatment EBV‐DNA and N stage with post‐RT EBV‐DNA and RLN CNN improved the prognostic risk stratification for DMFS in NPC.Evidence Level4Technical EfficacyStage 2
Oropharyngeal samples versus lesion specimens at diagnosis in patients infected with monkeypox virus in Northern France
Authors: Ouafi Mahdi , Regueme Alexandre , Alcaraz Isabelle , Riviere Pierre , Bazus Helène , Salmon‐Rousseau Arnaud , Cappeliez Bertrand , Cartier Noémie , Guigon Aurélie , Lazrek Mouna , Bocket Laurence , Faure Emmanuel , Robineau Olivier , Hober Didier , Alidjinou Enagnon Kazali 
Published: November 2022

AbstractThe ongoing outbreak of monkeypox virus (MPXV) is the largest one in historically non‐endemic countries. Early reports described atypical epidemiological and clinical presentations. We investigated MPXV DNA detection in oropharyngeal samples (OPS), and compared the viral load to that in lesion samples at diagnosis in patients infected with MPXV. We retrospectively included patients suspected to have monkeypox in Northern France, who underwent a MPXV PCR in the Virology Laboratory, University Hospital of Lille, from May 23 to August 18, 2022. Overall, a total of 228 patients (376 samples) were included. A positive result in at least one sample was found in 138 patients (60.5%). We compared PCR results between OPS and lesion samples (i.e., cutaneous or anal/rectal samples) in patients with both samples. A positive result in OPS was observed in 54 out of 60 patients (90%). The viral load in OPS (median Ct value = 29.5; interquartile range [IQR] = 24.7−34) was significantly lower than that in lesion samples (median Ct value = 17.8; IQR = 16.3 and 19.7) (p < 0.0001). This report shows that pharyngeal sampling does not bring additional information for the initial diagnosis in patients presenting with typical lesions.