bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes in emergency versus electively scheduled cases of placenta accreta spectrum disorder managed by cesarean‐hysterectomy within a multidisciplinary care team
Authors: Flores‐Mendoza Homero , Chandran Anjana Ravi , Hernandez‐Nieto Carlos , Murji Ally , Allen Lisa , Windrim Rory C. , Kingdom John C. , Hobson Sebastian R. 
Published: January 2022

AbstractObjectiveCompare maternal and perinatal outcomes between emergency and electively scheduled cesarean‐hysterectomy for placenta accreta spectrum (PAS) disorders.MethodSingle‐center retrospective cohort study including 125 cases of antenatally suspected and pathologically confirmed PAS disorders. Maternal and perinatal outcomes were analyzed. Multivariate logistic regression was used to test associations. Survival curves exploring risk factors for emergency birth were sought.Results25 (20%) and 100 (80%) patients had emergency and electively scheduled birth, respectively. Emergency birth had a higher estimated blood loss (2772 [2256.75] vs. 1561.19 [1152.95], P < 0.001), with a higher rate of coagulopathy (40% vs. 6%; P < 0.001) and bladder injury (44% vs. 13%; P < 0.001); and was associated with increased rates of blood transfusion (aOR 4.9, CI95% 1.3–17.5, P = 0.01), coagulopathy (aOR 16.4, CI95% 2.6–101.4, P = 0.002) and urinary tract injury (aOR 6.96, CI95% 1.5–30.7, P = 0.01). Gestational age at birth was lower in the emergency group (31.55 [4.75] vs. 35.19 [2.77], P = 0.001), no difference in perinatal mortality was found. A sonographically short cervix and/or history of APH had an increased cumulative risk of emergency birth with advancing gestational age.ConclusionPatients with PAS disorders managed in a tertiary center by a multidisciplinary team requiring emergency birth have increased maternal morbidity and poorer perinatal outcomes than those with electively scheduled birth.
The association between gestational weight gain and perinatal outcomes among underweight women with twin pregnancy in Japan
Authors: Maeda Yuto , Ogawa Kohei , Morisaki Naho , Sago Haruhiko 
Published: January 2022

AbstractObjectiveTo clarify the association between gestational weight gain (GWG) and pregnancy outcomes in underweight women with twin pregnancies in Japan.MethodsThis retrospective study derived data from the Japan Society of Obstetrics and Gynecology perinatal database between 2007 and 2015. We included 5049 underweight (pre‐pregnancy body mass index [BMI] <18.5 kg/m2) and 20 812 (BMI ≥18.5 and <25 kg/m2) normal‐weight, twin‐pregnant women. Weekly GWG was stratified into 10 categories. Logistic regression was used to assess the effects of GWG on pregnancy. The primary outcomes evaluated were small‐for‐gestational age (SGA), preterm birth, preeclampsia, and cesarean delivery.ResultsIn underweight group, high GWG was associated with significant risk reductions in both twins being SGA, at least one twin being SGA, very preterm birth, and extreme preterm birth, while a risk increase was observed in preeclampsia. Compared to women with GWG of 0.25–0.30 kg/week, the risk of preeclampsia was significantly higher in women with GWG >0.35 kg/week. No association was observed between GWG and cesarean delivery. These associations were similar in the normal‐weight group.ConclusionUnderweight women with twin pregnancies showed an inverse association between GWG and SGA or preterm birth. The risk of preeclampsia was higher in women who gained >0.35 kg/week.
Effects of polyethylene glycol on root and shoot production in zoysiagrasses
Authors: Cox Katherine D. , Kenworthy Kevin E. , Erickson John , Rios Esteban , Unruh Joseph B. 
Published: February 2022

AbstractIncreasing urban growth has placed a strain on limited potable water resources. Therefore, improved drought tolerance in turfgrass is important to reduce the need for supplemental irrigation to maintain the aesthetic value and functionality of turfgrass areas. Field evaluations are subject to variability in irrigation patterns, wind, soil, and drainage patterns within an experimental area. The objectives were to evaluate the effect of polyethylene glycol (PEG) on root and shoot production in species of Zoysia and determine if PEG is suitable for screening genotypes for drought responses. Two experiments were conducted, each arranged as a randomized complete block design. Experiments used plants grown in conetainers with and without PEG in hydroponic culture. Plants were evaluated for root length density, root surface area, root diameter, leaf mass, leaf wilting, and turfgrass quality. The PEG treatment produced minimal differences. The results indicated that higher PEG concentrations are needed to elucidate drought responses and observe differential drought responses among zoysiagrasses.
Four models of pharmacist‐integrated office‐based opioid treatment
Authors: Caron Olivia , Fay Allison E. , Pressley Haley , Seamon Gwen , Taylor Shawn Riser , Wilson Courtenay Gilmore 
Published: January 2022

AbstractPurposeIn 2019, one point six million Americans had opioid use disorder (OUD), yet only 18% of those patients received treatment with evidence‐based medications. Office‐based opioid treatment (OBOT) is the provision of care for OUD with buprenorphine, in various formulations including combination with naloxone, and naltrexone. Currently, there are few reports of physician‐pharmacist collaborative practice models for OBOT. The purpose of this study was to identify common roles, clinical backgrounds, and barriers of pharmacists within four pharmacist‐integrated OBOT services in one community.MethodsFour pharmacists implemented OBOT services in a family medicine (FM) residency, obstetrics‐gynecology residency, a physician‐owned FM practice, and a Federally Qualified Health Center. Each pharmacist detailed the evolution of OBOT models at their respective sites. Using a 21‐item questionnaire comprised of closed and open‐ended questions, the four pharmacists describe: the setting's OBOT; the pharmacist's OUD‐related training; pharmacist‐related OBOT activities; and barriers to implementation.ResultsOne pharmacist spends 10 to 20 h/wk on OBOT, while the others spend less than 10 h. In terms of patient care, two pharmacists conducted intake, group visits, collected vitals, and ensured naloxone access. All pharmacists counseled patients and conducted follow‐up visits. For nonpatient care activities, three pharmacists developed OBOT policies/procedures, and four coordinated care and consulted on OBOT cases. To prepare for this, two pharmacists learned about OUD in pharmacy school, two pharmacists completed the buprenorphine waiver‐training course, two pharmacists learned about OUD in residency, and three pharmacists attended continuing education. Barriers identified were lack of designated time, funding, and ability to prescribe buprenorphine.ConclusionPharmacists can effectively integrate into many OBOT settings. Future work should standardize the optimal role of the pharmacist, expand OUD pharmacy education, and advocate for pharmacists as waivered providers.
Clinical features and outcomes of duodenal‐type follicular lymphoma: A single‐center retrospective study
Authors: Kamijo Kimimori , Shimomura Yoshimitsu , Yoshioka Satoshi , Yamashita Daisuke , Hara Shigeo , Ishikawa Takayuki 
Published: February 2022

AbstractDuodenal‐type follicular lymphoma (FL) is a rare and newly recognized disease. Few data are available on the outcomes and treatment strategies for patients with duodenal‐type FL. We aimed to investigate the clinical features and outcomes of duodenal‐type FL. We defined duodenal‐type FL as involvement of the duodenum, without nodal or extranodal lesions other than intestinal lesions, pathologically diagnosed as FL. We reviewed 26 patients with duodenal‐type FL between January 2011 and December 2020 at Kobe City Hospital Organization, Kobe City Medical Center General Hospital. In particular, patients were selected for the watch and wait (WW) strategy and followed up with regular esophagogastroduodenoscopy about once a year at our institution. The patient characteristics were as follows: median age 63.5 years (range: 42–78), sex (male, 15; female, 11), stage (I, 26), and grade (I, 26). Regarding treatment strategies, 23 patients were selected for the WW strategy, and three patients received initial rituximab therapy. The median follow‐up period was 65.5 months (range: 0.2–109). Five‐year progression‐free survival and 5‐year overall survival rates were 86.3% and 100%, respectively. Among the 23 patients selected for the WW strategy, six had spontaneous complete regression, and 14 had stable disease, and three had progressive disease, including one with histologic transformation. The WW strategy for patients with duodenal‐type FL could be an appropriate and safe treatment option. However, in several cases, disease progression was documented, and regular follow‐up is important.
Endoscopic ultrasound‐guided hepaticogastrostomy versus hepaticogastrostomy with antegrade stenting for malignant distal biliary obstruction
Authors: Ishiwatari Hirotoshi , Ishikawa Kazuma , Niiya Fumitaka , Matsubayashi Hiroyuki , Kishida Yoshihiro , Yoshida Masao , Kawata Noboru , Imai Kenichiro , Hotta Kinichi , Ono Hiroyuki 
Published: January 2022

AbstractBackgroundRecurrent biliary obstruction (RBO) is a possible complication of endoscopic ultrasound‐guided hepaticogastrostomy (EUS‐HGS) in patients with malignant distal biliary obstruction (MDBO). Therefore, adding antegrade stenting across MDBO, followed by EUS‐HGS (EUS‐HGAS), may prolong the time to RBO (TRBO). We aimed to compare the outcomes of EUS‐HGS and HGAS.MethodsWe retrospectively evaluated consecutive patients who underwent EUS‐HGS or HGAS between July 2016 and November 2020. The TRBO, overall survival (OS), and adverse event (AE) rate were compared between the groups. The risk factors for RBO were determined using a multivariable Cox proportional hazards model.ResultsThis study included 96 patients (EUS‐HGS, n = 58; HGAS, n = 38). There was a significant difference in the cause of endoscopic retrograde cholangiopancreatography failure and the HGS stent type between the groups. A significant difference was found in TRBO (234 days vs not reached, P = .036), whereas no significant difference was found in the OS (123 vs 126 days, P = .76). The AE rate was not significantly different. Multivariable analysis revealed that EUS‐HGS was an independent risk factor for RBO (hazard ratio: 4.01, 95% confidence interval: 1.16‐13.9).ConclusionsEndoscopic ultrasound‐guided hepaticogastrostomy prolonged the TRBO compared with EUS‐HGS for biliary drainage in patients with MDBO.
The male reproductive system in whip spiders (Arachnida: Amblypygi)
Authors: Löscher Andreas , Krenn Harald W. , Schwaha Thomas , Seiter Michael 
Published: January 2022

AbstractWhip spiders (Arachnida, Amblypygi), like many other soil arthropods, transfer their spermatozoa indirectly via a stalked spermatophore. While the complex courtship behavior as well as the morphological differences of spermatophores and corresponding female genitalia between taxa have received great attention in the past, comparative research on the internal reproductive system is lacking so far. In this study, the morphology of the male whip spiders of four neoamblypygid taxa has been comparatively studied via computer tomography and subsequent 3D reconstruction. We investigated four species belonging to the Neoamblypygi, that is, the phrynichid species Damon medius (Damoninae), and Euphrynichus bacillifer (Phrynichidae), the phrynid species Phrynus hispaniolae (Phrynidae), and the charontid species Charon grayi (Charontidae). The male reproductive organs consist of paired testes and two pairs of accessory glands, the ventral and lateral glands, which project their ducts anteriorly into the ventrally located unpaired spermatophore producing organ where the respective seminal and secretory reservoirs are located. While this general organization of the male reproductive system is similar among all investigated taxa, there are some notable differences in some structures. The most surprising findings include the complete absence of ventral glands in D. medius, the presence of unique spherical ventral gland reservoirs in C. grayi as well as differences in the organization of the seminal and secretory reservoirs and their connections to the inner genital slit. In addition, the secretory products of both, ventral and lateral glands, are stored in combined secretory reservoirs in E. bacillifer and P. hispaniolae. This study is the first to show that there is some morphological variation in the male reproductive system in Neoamblypygi. These results are the basis for the reconstruction of the Bauplan for the reproductive organs of the whip spiders.
Improving Nasopharyngeal Swab Technique via Simulation for Frontline Workers
Authors: Instrum Ryan S. , Koch Robert W. , Rocha Taciano , Rohani Seyed Alizera , Ladak Hanif , Agrawal Sumit K. , Sowerby Leigh J 
Published: February 2022

Objectives/HypothesisNasopharyngeal swabs currently remain the gold standard for COVID‐19 sample collection. A surge in testing volume has resulted in a large number of health care workers who are unfamiliar with nasal anatomy performing this test, which can lead to improper collection practices culminating in false‐negative results and complications. Therefore, we aimed to assess the accuracy and educational potential of a realistic 3D‐printed nasal swab simulator to expedite health care workers' skill acquisition.Study DesignProspective pre‐post interventional study.MethodsA nasal swab task trainer (NSTT) was developed to scale from computed tomography data with a deviated septum. Frontline workers at COVID‐19 testing sites in Ontario, Canada, were recruited to use the NSTT for nasopharyngeal swab training. Integrated video recording capability allowed participants to self‐evaluate procedure accuracy. A five‐point Likert scale was collected regarding the NSTT's educational value and procedural fidelity.ResultsSixty‐two frontline workers included in the study were primarily registered nurses (52%) or paramedics (16%). Following simulator use, self‐assessed accuracy improved in 77% of all participants and 100% of participants who expressed low confidence before training. Ninety‐four percent reported that the NSTT provided a complete educational experience, and 82% regarded the system as a more effective training approach than what is currently available. Eighty‐one indicated that the simulator should be used at all COVID‐19 testing sites, with 77% stating province‐wide implementation was warranted.ConclusionsThe nasal swab task trainer is an effective educational tool that appears well‐suited for improved skill acquisition in COVID‐19 testing and may be useful for training other nasal swab applications.Level of Evidence3 Laryngoscope, 133:38–42, 2023
Excellent dispersion stability and enhanced tribological properties of biocarbon‐based magnesium silicate hydroxide modified with oleylamine
Authors: Gao Rongqin , Chang Qiuying , Wang Kai 
Published: January 2022

AbstractBiocarbon‐based magnesium silicate hydroxide (M@C‐ON) was synthesised by hydrothermal method with synthesised magnesium silicate hydroxide (MSH) as the template, glucose as carbon source and oleylamine (ON) as the modified agent. The outstanding dispersion stability of M@C‐ON as lubricant additives in PAO10 with ON as dispersant was proved by accelerated centrifugation and static sedimentation tests. The tribological properties of M@C‐ON as lubricant additive were tested under different concentrations and working conditions, and it was found that oil samples containing M@C‐ON as additive showed enhanced tribological properties than that containing MSH under 600 N, 600 RPM. At the same time, the anti‐wear performance was thought to be affected by the external energy acted on nano‐additives. When M@C‐ON as additive fully functioned, a continuous carbon layer formed on the contact area and the repairing effect of inner MSH of M@C‐ON were considered as the factors to play an anti‐wear role.
An investigation into the tribological behaviour of cutting fluid additives on Ti‐6Al‐4V alloy
Authors: Ma Junhui , Gali Olufisayo A. , Riahi Reza A. 
Published: January 2022

AbstractThe performance of polymer‐based and phosphorus‐based cutting fluid additives have been shown to depend on the machining conditions employed. This study investigated the tribological behaviour behind the previously reported machining performance of polymer‐based and phosphorus‐based additives on Ti‐6Al‐4V using ball‐on‐disc tests. The coefficient of friction (COF) was evaluated using ball‐on‐disc tests, surface characterisation was performed on the Ti‐6Al‐4V and steel ball counterfaces to investigate the wear and friction reduction mechanisms. The tribological performance of the phosphorus‐based additive was observed to be influenced by the applied load and temperature. The activation of this additive resulted in a reduction in COF at elevated temperatures. However, the activation temperature was observed to be influenced by the applied load. The COF associated with the polymer‐based additive was noted to increase as the temperature increased, regardless of the applied load. The formation of tribolayers from the additives was related to the COF behaviour as well as the surface damage on Ti‐6Al‐4V and lower material transfer to the steel counterfaces.
Criticality of Schrödinger forms and Liouville‐type property
Authors: Takeda Masayoshi 
Published: February 2022

AbstractPinchover [23] proved Liouville‐type property for Schrödinger operators by applying the criticality theory. We extend in [28] the criticality theory to Schrödinger forms. Employing this result, we show Liouville‐type property for Schrödinger forms with non‐local part.
Flavanol Consumption in Healthy Men Preserves Integrity of Immunological‐Endothelial Barrier Cell Functions: Nutri(epi)genomic Analysis
Authors: Milenkovic Dragan , Rodriguez‐Mateos Ana , Lucosz Margarete , Istas Geoffrey , Declerck Ken , Sansone Roberto , Deenen René , Köhrer Karl , Corral‐Jara Karla Fabiola , Altschmied Joachim , Haendeler Judith , Kelm Malte , Berghe Wim Vanden , Heiss Christian 
Published: January 2022

ScopeWhile cocoa flavanol (CF) consumption improves cardiovascular risk biomarkers, molecular mechanisms underlying their protective effects are not understood.ObjectiveTo investigate nutri(epi)genomic effects of CF and identify regulatory networks potential mediating vascular health benefits.Methods and ResultsTwenty healthy middle‐aged men consume CF (bi‐daily 450 mg) or control drinks for 1 month. Microarray analysis identifies 2235 differentially expressed genes (DEG) involved in processes regulating immune response, cell adhesion, or cytoskeleton organization. Distinct patterns of DEG correlate with CF‐related changes in endothelial function, arterial stiffness, and blood pressure. DEG profile negatively correlates with expression profiles of cardiovascular disease patients. CF modulated DNA methylation profile of genes implicates in cell adhesion, actin cytoskeleton organization, or cell signaling. In silico docking analyses indicate that CF metabolites have the potential of binding to cell signaling proteins and transcription factors. Incubation of plasma obtained after CF consumption decrease monocyte to endothelial adhesion and dose‐dependently increase nitric oxide‐dependent chemotaxis of circulating angiogenic cells further validating the biological functions of CF metabolites.ConclusionIn healthy humans, CF consumption may mediate vascular protective effects by modulating gene expression and DNA methylation towards a cardiovascular protective effect, in agreement with clinical results, by preserving integrity of immunological‐endothelial barrier functions.
A reconstruction approach for proton computed tomography by modeling the integral depth dose of the scanning proton pencil beam
Authors: Chen Xinyuan , Medrano Maria , Sun Baozhou , Hao Yao , Reynoso Francisco J. , Darafsheh Arash , Yang Deshan , Zhang Tiezhi , Zhao Tianyu 
Published: February 2022

AbstractPurposeTo present a proton computed tomography (pCT) reconstruction approach that models the integral depth dose (IDD) of the clinical scanning proton beam into beamlets. Using a multilayer ionization chamber (MLIC) as the imager, the proposed pCT system and the reconstruction approach can minimize extra ambient neutron dose and simplify the beamline design by eliminating an additional collimator to confine the proton beam.MethodsMonte Carlo simulation was applied to digitally simulate the IDDs of the exiting proton beams detected by the MLIC. A forward model was developed to model each IDD into a weighted sum of percentage depth doses of the constituent beamlets separated laterally by 1 mm. The water equivalent path lengths (WEPLs) of the beamlets were determined by iteratively minimizing the squared L2‐norm between the forward projected and simulated IDDs. The final WEPL values were reconstructed to pCT images, that is, proton stopping power ratio (SPR) maps, through simultaneous algebraic reconstruction technique with total variation regularization. The reconstruction process was tested with a digital cylindrical water‐based phantom and an ICRP adult reference computational phantom. The mean of SPR within regions of interest (ROIs) and the WEPL along a 4 mm‐wide beam () were compared with the reference values. The spatial resolution was analyzed at the edge of a cortical insert of the cylindrical phantom.ResultsThe percentage deviations from reference SPR were within ±1% in all selected ROIs. The mean absolute error of the reconstructed SPR was 0.33%, 0.19%, and 0.27% for the cylindrical phantom, the adult phantom at the head and lung region, respectively. The corresponding percentage deviations from reference were 0.48 ± 0.64%, 0.28 ± 0.48%, and 0.22 ± 0.49%. The full width at half maximum of the line spread function (LSF) derived from the radial edge spread function (ESF) of a cortical insert was 0.13 cm. The frequency at 10% of the modulation transfer function (MTF) was 6.38 cm–1. The mean signal‐to‐noise ratio (SNR) of all the inserts was 2.45. The mean imaging dose was 0.29 and 0.25 cGy at the head and lung region of the adult phantom, respectively.ConclusionA new pCT reconstruction approach was developed by modeling the IDDs of the uncollimated scanning proton beams in the pencil beam geometry. SPR accuracy within ±1%, spatial resolution of better than 2 mm at 10% MTF, and imaging dose at the magnitude of mGy were achieved. Potential side effects caused by neutron dose were eliminated by removing the extra beam collimator.