bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Multidisciplinary Opioid-Reduction Pathway for Robotic Prostatectomy: Outcomes at Year One
Authors: Manning Michael W. , Whittle John , Fuller Matthew , Cooper Sara H. , Manning Erin L , Chapman Joe , Moul Judd W , Miller Timothy E 
Published: October 2022

Abstract
Background: Opioid use has come under increasing scrutiny, driven in part by the opioid crisis and growing concerns that up to 6% of opioid-naïve patients may become chronic opioid users. This has resulted in a revaluation of perioperative practice. For this reason, we implemented a multidisciplinary pathway to reduce perioperative opioid usage through education and standardization of practice.
Methods: A single centre retrospective evaluation was performed after one year, comparing the outcomes to those of the two years prior to pathway implementation. Comparisons were made between pre- vs. post pathway change by 2:1 propensity matching between cohorts. Univariate linear regression models were created using demographic variables with those that were p<0.15 included in the final model and using post-operative opioid use (in oral morphine equivalents, OME) as the primary outcome.
Results: We found that intraoperative opioid use was significantly decreased 38.2mg(28.3) vs. 18.0mg(40.4) oral morphine equivalents (OME), p<.001, as was post-operative opioid use for the duration of the hospitalization, 46.3mg(49.5) vs. 35.49mg(43.7) OME, p=0.002. In subgroup analysis of those that received some intraoperative opioids (n= 152) and those that received no opioids (n=34), we found that both groups required fewer opioids in the post-operative period 47.0mg(47.7) vs. 32.4mg(40.6) OME; p=0.001; +intraoperative opioids ; 62.4mg(62.9) vs. 35.8mg(27.7) OME; p=0.13; -intraoperative opioids. Time to discharge from the PACU was reduced in both groups 215min(199) vs. 167min(122); p<0.003; +intraoperative opioids and 253min(270) vs. 167min(105); p=0.028; -intraoperative opioids. The duration of time until meeting discharge criteria from PACU was 221min(205) vs. 170min(120); p=0.001. Hospital length of stay (LOS) was significantly reduced 1.4 days(1.3) vs. 1.2 days(0.8); p=0.005. Both sub-groups demonstrated reduced hospital LOS 1.5 days(1.4) vs. 1.2 days(0.8); p=0.0047; +intraoperative opioids and 1.7 days(1.6) vs. 1.3 days(0.9); p=0.0583; -intraoperative opioids. Average pain scores during PACU admission and Post-PACU until discharge, were not statistically different between cohorts.
Conclusions: These findings underscore the effectiveness of a multidisciplinary approach to reduce opioids. Furthermore, it demonstrates improved patient outcomes as measured by both shorter PACU and hospital length of stay, in addition to almost 50% reduction in perioperative opioid use.
Picrate salts with bipyridine derivatives: Intra and intermolecular aspects
Authors: Moura Ana L. S. , Machado Pedro H. , Corrêa Rodrigo S. 
Published: October 2022

Abstract
Here, we present the preparation and characterization of two novel picrate salts. Compound 1 (DPK-PA) crystallizes in the triclinic system and centrosymmetric space group P\(\stackrel{-}{1}\), with unit cell parameters a = 9.378(17) Å, b = 9.790(15) Å, c = 10.141(16) Å, α = 99.63(7)°, β = 99.09(8)° and γ = 102.55(8)°, while the compound 2 (BBBPY-PA) crystallizes in the non-centrosymmetric P212121 space group, orthorhombic unit cell parameters a = 6.3902(6) Å, b = 23.416(3) Å and c = 16.7320(18) Å. Both crystal structures present an ion-pair in the asymmetric unit, one picrate anion, and one bipyridine derivative. In the compound 1 structure, the molecule of DPK presents one intramolecular N1-H…N Hbond that contributes to stabilizing the planar conformation of DPK. The absence of intramolecular Hbonding in compound 2 can be explained by the steric hindrance of the tert-butyl group. For 1 and 2, the crystal packing is stabilized N-H…O strong hydrogen bonding interactions, which could be identified by the Hirshfield Surface analysis and fingerprint plots. The compounds were also studied by UV-Vis and infrared analyses, which may support the statement of the formation of new material. Finally, as an attempt to obtain a molecular system to act as a chemical sensor, we studied the fluorescence of both compounds, in solution and in solid state, however, no fluorescence was observed.
Eeg Microstate Analysis in Patients With Disorders of Consciousness and Its Clinical Relevance
Authors: Toplutaş Eren , Aydın Fatma , Hanoğlu Lütfü 
Published: October 2022

Abstract
Disorders of Consciousness are divided into categories such as vegetative and minimally conscious states. Objective measures that allow correct identification of vegetative and minimally conscious state patients are required. EEG Microstate analysis is a promising approach that we believe has the potential to be effective in examining the resting state activities of the brain in different stages of consciousness by allowing the proper identification of vegetative and minimally conscious patients. As a result, we try to identify clinical evaluation scales and microstate characteristics with resting state EEGs from individuals with Disorders of Consciousness. Our prospective observational study included thirty individuals with a Disorder of Consciousness. As the control group, we included EEG data from 18 healthy individuals. We made clinical evaluations using patient behavior scales. We also analyzed the EEG data quantitatively and compared statistically using microstate analysis. In our study, microstate D coverage and occurrence differed substantially between vegetative and minimally conscious state patients. We performed microstate analysis on resting-state EEGs of patients with Disorders of Consciousness. There was a strong connection between microstate D characteristics and clinical scale scores. We also found significant relationships between microstate transition probabilities and clinical scale scores. We have shown that microstate D is the most potent parameter representing consciousness. Microstate analysis appears to be a strong option for future use in the diagnosis, follow-up, and treatment response of patients with Disorders of Consciousness.
Telemedicine in Healthcare Delivery: Knowledge, Attitude, and Skill Set of Medical Students in Selected Universities in Africa
Authors: Babatunde Abdulhammed Opeyemi , Paul Innocent Kitandu , Olawuyi Dimeji Abdulsobur , Brimmo Farida Oluwabukola , Adetoye Ezekiel Adedapo , Omotiti Abass , Udohchukwu Okereke Promise , Arama Umulkhairah Onyioiza , Uchenna Emmanuel Oranwusi , Ahmed Aisha Asila , Alawad Ragda , Dinga Bobga , Agboola Progress , Rabiu Aisha Temitope , Ogah Okechukwu 
Published: October 2022

Abstract
Background :Telemedicine is a rapidly expanding technology used in healthcare settings, especially since the emergence of COVID-19. For this intervention to be implemented successfully, important skills are required from health professionals. Hence, this study seeks to determine the preparedness of African medical students for the use of telemedicine in healthcare delivery by assessing their knowledge, attitude, and skill set ,
Methods: This was a descriptive cross-sectional study. Data were collected online through a 33-item pre-tested, self-administered questionnaire from three selected medical schools in Africa. Data were analysed using descriptive and analytical statistics with a significant level of 0.05. Data analysis was done on SPSS version 20,
Results : Only 559 respondents were eligible for the study. 338 (60.5%) were male and the most prevalent age range was 21-23 years (276, 49.4%). 346 (61.9%) had good knowledge while 461 (82.5%) expressed a good attitude toward telemedicine. Only 144 (25.8%) had a good skill set in using telemedicine. 513 (91.6%) respondents agreed and strongly agreed that the use of telemedicine should be included in medical training. There was a statistically significant association between the skill set of respondents and schools (p=0.001) and gender (p<0.001),
Conclusions: The respondents have a good attitude but average knowledge and poor skill set of telemedicine usage in healthcare delivery. However, the majority are interested in learning about telemedicine in medical training. This study shows the need to incorporate telemedicine within the curricula of African medical schools.
Systematic Analysis of GT1 Family Genes and Their Regulation in Anthocyanin Metabolism in Red Maple
Authors: Xu Hao , Zhu Qing , Lu Xiaoyu 
Published: October 2022

Abstract
Glycosyltransferases (GTs) have a crucial role in the glycosylation of secondary metabolites, detoxification of endogenous or exogenous substances, body defense, and hormone regulation in plants. The GT1 family has the largest number of characterized enzymes in 111 GT families that are known for their excellent glycosylation capacities toward numerous valued small molecules. The colorful foliage of red maple is a vital agronomic trait, and studies have confirmed that massive anthocyanin accumulation led to the redness of leaves. In red maple, glycosylation is the essential step of anthocyanin biosynthesis and the prerequisite of further modifications, which usually enhances stability. Here, a genome-wide characterization analysis of the GT1 family in red maple was performed. A total of 560 GT genes were identified in the red maple genome; among them, 122 members belonged to the GT1 family. All these members were unevenly distributed across 19 chromosomes, with most located in the chloroplast. These GT1 genes had 1–16 exons. Most 122 GT1 proteins in red maple contained GT-GTB-type domain and GT1-Gtf-like domain. In total, 18 GT1 proteins might have played pivotal evolutionary roles in red maple. The network analysis revealed that the regulatory effect of GT1 family genes on anthocyanin in red maple leaves could be divided into direct and indirect regulation. The study results not only clarified the roles of the GT1 family in red maple but also laid a cornerstone for further functional analysis of this gene family in Acer plants.
Novel ionic liquid 4,4ʹ-trimethylenedipiperidine phosphate catalysed greener and efficient synthesis of dihydro pyrano [2,3-c] pyrazole
Authors: Tanpure Sagar , Mulik Abhijeet , Rajmane Mohan , Lawande Shamrao 
Published: October 2022

Abstract
A novel robust acidic ionic liquid 4,4ʹ-trimethylenedipiperidine phosphate was synthesised from 4, 4ʹ-trimethylenedipiperidine and phosphoric acid. The prepared catalyst was characterized by FTIR, 1H-NMR, 13C NMR and Mass Spectroscopy. The synthesized novel catalyst was found to be competent for synthesis of pyranopyrazole derivatives through one-pot multicomponent condensation of diverse aryl aldehyde with malononitrile, ethyl acetoacetate, and hydrazine hydrate in presence of a catalytic amount of dihydrogen 4,4ʹ-trimethylenedipiperidine phosphate [H2-TMDP][HPO4] as an efficient and inexpensive catalyst at room temperature. Merit of this meticulously designed protocol are the use of novel ionic liquid, easy work-up process, good to excellent yields, short reaction time, and purification without column chromatography.
HIV-1 infection results in upregulation of Sphingosine-1-phosphate receptor 1 in the human thymus
Authors: Resop Rachel S. , Salvatore Bradley , Kim Shawn J. , Gordon Brent , Blom Bianca , Vatakis Dimitrios N. , Uittenbogaart Christel H. 
Published: October 2022

Abstract
Regeneration of functional naïve T lymphocytes following the onset of infection remains a crucial issue for HIV + individuals, even while adhering to Antiretroviral Therapy (ART). Thus far, reports on the impact of HIV-1 infection on the entry of thymic precursors and the egress of functional naïve T lymphocytes are limited. Therefore, we examined the impact of HIV-1 on Sphingosine-1-phosphate (S1P) signaling, which governs the egress of functional naïve thymocytes from the thymus to the periphery. Using in vitro experiments with primary human thymocytes and in vivo and ex vivo studies with humanized mice, we demonstrate that HIV-1 infection upregulates the expression of S1P receptor 1 (S1PR1) in the human thymus. Intriguingly, this upregulation occurs both during intrathymic infection (direct infection of the human thymic implant) as well as systemic infection in humanized mice. Moreover, the increase in pro-inflammatory cytokines in infected thymi and the upregulation of S1PR1 in response to in vitro exposure to Interferon-Beta (IFN-β) and Tumor Necrosis Factor-Alpha (TNF-α) indicate that the cytokine dysregulation following HIV infection may contribute to upregulation of S1PR1. Finally, an increased presence of CD3hiCD69- (fully mature) as well as CD3hiCD69+ (less mature) T cells in the spleen during HIV infection in humanized mice, as well as an earlier expression during thymocyte development, indicate that the upregulation of this receptor translates to increased and accelerated egress from the thymus. The egress of thymocytes that are not functionally mature from the thymus to peripheral blood and lymphoid organs may have implications for the immune function of people living with HIV (PLWH).
Exact solution for time sequence optimization of road reconstruction projects considering network capacity limitation
Authors: Chen Qun , Ye Shi , Wang Yan 
Published: October 2022

Abstract
The problem is often encountered in road network reconstruction: there are multiple road sections (each road section is defined as a project or work zone) that need to be reconstructed in a period and how to arrange the time sequence of these projects to minimize the total construction duration under the premise of meeting the capacity constraints of the road network. This paper proposes an exact solution algorithm based on the branch-and-bound approach to solve the problem. The methods for estimating the upper and lower bounds of the duration of the project combination represented by each node are proposed, and the pruning rules and search principles are defined. The optimality of the solution obtained by the proposed algorithm is proved. Finally, an example is presented to demonstrate the search process and the effectiveness of the algorithm.
Study on proportion-making and stability of surrounding rock model test of water-inrush roadway
Authors: Li Jiwei , Li Jianguang , Li Qingkun , Cheng Zhongyue , Zhou Ziyi 
Published: October 2022

Abstract
Groundwater is one of the key problems that must be faced and solved in underground engineering. Under special conditions, large-scale water damage accidents will be formed. Therefore, it is of great engineering significance to study the stability of surrounding rock of water-inrush roadway. This study focuses on laboratory experiments to study the preparation of similar materials, establish multiple linear regression equations of the ratio and physical parameters, analyze the influence law of roadway depth of roadway, water inrush height and water inrush time on the stability of surrounding rock of water-inrush roadway, and verify and expand it with numerical simulation. The experimental results show that the sensitivity of each factor to roadway stability is as follows: water inrush height > water inrush time > depth of roadway; In the test within 24 hours after water inrush, the sensitivity of each factor to roadway stability is also the height of water inrush > the time of water inrush > the depth of burial. This conclusion can provide an important basis for the rescue work after roadway water inrush and enrich the relevant test simulation after roadway water inrush.
General inertial proximal stochastic variance reductiongradient for nonconvex nonsmooth optimization
Authors: Sun shuya , He lulu 
Published: October 2022

Abstract
In this paper, motivated by the competitive performance of proximal stochasticvariance reduction gradient (Prox-SVRG) method, a novel general inertial Prox-SVRG (GIProx-SVRG) algorithm is proposed for solving a class of nonconvexfinite sum problem. More precisely, the Nesterov’s momentum trick based ex-trapolation accelerated step is incorporated into the framework of Prox-SVRG.In contrast to Prox-SVRG, GIProx-SVRG possesses more general accelerate ex-pression and thus can potentially achieves accelerated convergence. Moreover,based on the supermartling convergence theory and the error bound condition,we establish a linear convergence rate for the iterate sequence generated byGIProx-SVRG algorithm. We observe that there is no theory exists in whichthe general extrapolation technique is combined in Prox-SVRG, whereas weestablish such a theory in this paper. Experimental results demonstrate thesuperiority of our method over the-state-of-the-art methods.
A novel ZnS-CdS nanocomposite as a visible active photocatalyst for degradation of synthetic and real wastewaters
Authors: Khodamorady Minoo , Bahrami Kiumars 
Published: October 2022

Abstract
In this study, new magnetic nanocomposites with shell core structure with different molar ratios of ZnS-CdS were synthesized and their photocatalytic activity in dye removal from synthetic and real effluents in the presence of mercury high pressure lamp as a visible light source was investigated. Optimal photocatalyst with molar ratio of ZnS-CdS 0.25:0.75 showed the best performance in dye removal. Based on the particle distribution histogram of Fe3O4@BNPs@ZnS-CdS (ZnS/CdS: 0.25:0.75), particles with 60 to 100 nm have the highest abundance. According to the DRS results, hybridization of zinc sulfide with cadmium sulfide reduced the gap and as a result, light absorption was successfully extended to the visible area. The PL results confirm that the optimal photocatalyst (Fe3O4@BNPs@ZnS-CdS) has the lowest electron-hole recombination compared to Fe3O4@BNPs@ZnS and Fe3O4@BNPs@CdS. It should be noted that according to the DLS results, the charge on the optical photocomposite surface is negative at all acidic, alkaline and neutral pHs. One of the significant advantages in this study is the use of high-pressure mercury lamps as a light source, so that these lamps are very economical in terms of economy and also have a long life and excellent efficiency. The optimal photocatalyst not only showed excellent photocatalytic activity for the removal of methylene blue (96.6%) and methyl orange (70.9%) but also for the dye removal of textile effluents (Benton 98.5% and dark olive 100%). Introduced magnetic heterostructures are suitable options for dye removal from textile and spinning wastewaters.
Tailoring the hollow structure within CoSn(OH)6 nanocubes for advanced supercapacitors
Authors: Yang Zhiyong , Li Chunxia , Liu Fangfang , Lv Xiaowei , Zhang Lei , Wang Hui 
Published: October 2022

Abstract
Hollow structure is benefited for various application of the materials owing to it makes the materials the large surface area with more active sites. In this work, hollow structure was engineered into dense CoSn(OH)6 nanocube precursors by alkaline etching, resulting in both increased surface area and mesopores with large size. Hollow CoSn(OH)6 nanocubes as the active component of the cathode electrode exhibited a highly electrochemical capacitance of 1.136 mAh cm-2 at 2 mA cm-2 , larger than that of corresponding dense precursor. Meanwhile, good rate capability for hollow CoSn(OH)6 nanocubes was achieved by increasing 4-fold current density. Considering its facile fabrication and highly electrochemical performance, the obtained CoSn(OH)6 nanocubes are a promising material for use in energy storage.
Pendap as a Bengkulu Culinary Treasure
Authors: Iktarastiwi Nasfati , Marwanti M.Pd. Prof. Dr. 
Published: October 2022

Abstract
Pendap is currently the tourism potential of the Bengkulu area. However, the local wisdom of Pendap is still rarely studied. This study aims to determine Pendap as a culinary treasure typical of Bengkulu. This study uses a qualitative research design with the research subjects of Pendap producers and Bengkulu typical restaurant owners, data collection using observation, interviews, and documentation techniques. Data analysis used an interactive analysis model of data collection, reduction, data display, and conclusion drawing. The results of Pendap research have been around for a long time and are passed down from generation to generation and are often presented at community events. The treasure of Pendap can also be seen from the 8-hour cooking process, and has become a part of Bengkulu culinary. Pendap is successfully traded as a Bengkulu typical side dish because it lasts for 2 days without preservatives and for 2 weeks if packaged using a vacuum. Hopefully the results of this research can increase the understanding of people who are involved in the Bengkulu traditional culinary world to pay more attention and know about local wisdom, because few studies discuss related topics.
Keywords: Pendap, Local Cuisine, Bengkulu, Indonesia
Combined analysis of cytokines and neurofilaments improves differentiation and prognostication in ALS
Authors: Behzadi Arvin , Olesen Mads Nikolaj , Forsberg Karin , Pujol-Calderón Fani , Tjust Anton E. , Wuolikainen Anna , Madsen Jonna Skov , Brandslund Ivan , Blennow Kaj , Zetterberg Henrik , Asgari Nasrin , Andersen Peter Munch 
Published: October 2022

Abstract
Background
Amyotrophic lateral sclerosis (ALS) is a heterogeneous neurodegenerative syndrome hallmarked by adult-onset degeneration of upper and lower motor neurons and their associated tracts. ALS may be difficult to differentiate from some other neurological disorders termed ALS mimics and to estimate prognosis.
Methods
We retrospectively measured the concentrations of neurofilaments (NFs) and cytokines in cerebrospinal fluid (CSF) and plasma in ALS patients (n = 234) and ALS mimics (n = 44), to assess their association to diagnosis and prognosis in ALS. Two in-house developed enzyme-linked immunosorbent assays were used to measure NF light chain (NFL) and phosphorylated NF heavy chain (pNFH) in CSF. Single-molecule array was used to measure NFL in plasma and cytokines in CSF and plasma.
Results
Significantly higher concentrations of CSF tumor necrosis factor (TNF)-α and lower concentrations of plasma interleukin (IL)-1β were found in bulbar-onset ALS compared with ALS mimics. Plasma IL-6, plasma IL-17A and plasma TNF-α concentrations in ALS patients were significantly negatively correlated with the ALS functional rating scale revised and significantly positively correlated with King’s ALS clinical staging. Furthermore, plasma IL-6 and plasma TNF-α concentrations were significantly negatively correlated with the disease duration and significantly positively correlated with the disease progression rate in ALS patients. In both CSF and plasma in ALS patients, TNF-α was significantly positively correlated with NFL. ALS patients having plasma NFL or plasma IL-6 concentrations equal to or higher than the upper quartile (≥ Q3) showed a shorter disease duration compared with ALS patients having plasma NFL or plasma IL-6 equal to or lower than the median (≤ Q2).
Conclusions
Combined analysis of inflammatory and neurodegenerative biomarkers may be useful in differentiation between ALS and ALS-mimics. Such analysis may also provide useful prognostic information and facilitate stratification of less heterogeneous groups in clinical drug trials.