bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tracking control a twin-rotor helicopter used for building measuring with PID-MPC controller
Authors: Guo F 
Published: May 2022

Abstract
In recent years, due to the development of UAV (Unmanned aerial vehicle) technology, UAVs have been used in an increasingly wide range of applications, including the architecture industry. In the field of architecture, the technologies of capturing images of building conditions with UAVs have a huge development, such as architectural planning, remote terrain detection, construction safety supervision and so forth. In general, the applications can be expanded widly, owing to the convenient operation of UAVs for the flyers and that does not require a high degree of precision for the control. However, when it comes to penetration between and within buildings. The lack of flight vision and signal interference often leads to collisions and crashes. Hence, this paper studies how to further optimise the control accuracy of construction measurement UAVs. The aim is to reduce the difficulty of operating the UAV when it faces to interference during architecture measurement. In this paper, a three DOFs two-rotor UAV is selected as the object of study. A mathematical model of the UAV is constructed, which is followed by the designing of an advanced controller based on a PID controller and an MPC (model predictive controller) controller, used for realising offset free reference tracking when changing elevation, pitch and travel angles. The usage of this controller can significantly reduce the cost of control during flight to reduce control bias in the presence of disturbing factors. The application of the controller to UAVs allows for automated and intelligent UAV control.
Verification of elastic wave velocity tomography based on compressive sampling
Authors: Qiao X , Kobayashi Y , Oda K , Nakamura K 
Published: May 2022

Abstract
This paper verifies the compressive sampling(CS)-based elastic wave velocity tomography(EWT) technique. Conventional elastic wave velocity tomography necessitates the quantity of effort and time. Nevertheless, because the central premise of CS algorithm is to recover the original velocity distribution from random measurement subsampling, compressive sampling is adopted at overcoming this challenge. CS algorithm chose fewer paths from entire measurements during the measurement stage. After that, the L1-minimization optimization method adopts to recover the damage area and magnitude in the visualization stage. Because of hugely reduces the measurement workload and a high level of accuracy reconstruction, CS algorithm is more effective in comparison with the conventional algorithms of elastic wave velocity tomography.
Improving the properties of mortars by using recycled paper ash flakes
Authors: Tintisan M L , Siomin A C , Zaharie A , Manea D L 
Published: May 2022

Abstract
This study addresses the need to improve life on earth by finding a way to reintroduce ubiquitous waste back into the system. On a hand, there is the amount of cellulosic waste that can no longer be reintroduced into the paper recycling process. On the other hand, the amount of cement used globally, is growing alarmingly. My study seeks the balance of a mix of these two materials, which would generate desirable effects both from an engineering and ecological point of view. Paper ash, is a material made of particles of various sizes and can play various roles in the composition of mortars. The efficacy of particles up to 0.025 mm in size (powder ash) as a cement substitute and the efficiency of particles in size between 0.025 and 8 mm (flakes) as a pozzolanic additive are demonstrated. The results of the mechanical tests to which the samples were subjected show the possibility of reducing the amount of cement used in standard recipes by adding ash from recycled paper, without compromising the physical and mechanical properties of the mortars. The cement economy can rise up to 20 percent while the mechanical strength increases by 5-10 percent compared to the basic recipe.
Experimental research of main characteristics in a complex multi-layer plate heat exchanger
Authors: Yezhov V S , Semicheva N E , Burtsev A P , Brezhnev A V , Perepelitsa N S 
Published: May 2022

Abstract
The objective of this paper is research of main heat exchange characteristics in a complex multi-layer heat-exchanger with the purpose of determining heat exchanging process intensification dependencies and conditions during utilization of ventilation gas and emission low-grade heat with associated recovery of thermoelectricity.
The network makeup artist (NORMA-2.0): distinguishing annotated groups in a network using innovative layout strategies
Authors: Karatzas Evangelos , Koutrouli Mikaela , Baltoumas Fotis A , Papanikolopoulou Katerina , Bouyioukos Costas , Pavlopoulos Georgios A 
Published: May 2022

Abstract

Motivation
Network biology is a dominant player in today’s multi-omics era. Therefore, the need for visualization tools which can efficiently cope with intra-network heterogeneity emerges.

Results
NORMA-2.0 is a web application which uses efficient layouts to group together areas of interest in a network. In this version, NORMA-2.0 utilizes three different strategies to make such groupings as distinct as possible while it preserves all of the properties from its first version where one can handle multiple networks and annotation files simultaneously.

Availability and implementation
The web resource is available at http://norma.pavlopouloslab.info/. The source code is freely available at https://github.com/PavlopoulosLab/NORMA.
ReadItAndKeep: rapid decontamination of SARS-CoV-2 sequencing reads
Authors: Hunt Martin , Swann Jeremy , Constantinides Bede , Fowler Philip W , Iqbal Zamin 
Published: May 2022

AbstractSummaryViral sequence data from clinical samples frequently contain contaminating human reads, which must be removed prior to sharing for legal and ethical reasons. To enable host read removal for SARS-CoV-2 sequencing data on low-specification laptops, we developed ReadItAndKeep, a fast lightweight tool for Illumina and nanopore data that only keeps reads matching the SARS-CoV-2 genome. Peak RAM usage is typically below 10 MB, and runtime less than 1 min. We show that by excluding the polyA tail from the viral reference, ReadItAndKeep prevents bleed-through of human reads, whereas mapping to the human genome lets some reads escape. We believe our test approach (including all possible reads from the human genome, human samples from each of the 26 populations in the 1000 genomes data and a diverse set of SARS-CoV-2 genomes) will also be useful for others.Availability and implementationReadItAndKeep is implemented in C++, released under the MIT license, and available from https://github.com/GenomePathogenAnalysisService/read-it-and-keep.Supplementary informationSupplementary data are available at Bioinformatics online.
Building alternative consensus trees and supertrees usingk-means and Robinson and Foulds distance
Authors: Tahiri Nadia , Fichet Bernard , Makarenkov Vladimir 
Published: May 2022

AbstractMotivationEach gene has its own evolutionary history which can substantially differ from evolutionary histories of other genes. For example, some individual genes or operons can be affected by specific horizontal gene transfer or recombination events. Thus, the evolutionary history of each gene should be represented by its own phylogenetic tree which may display different evolutionary patterns from the species tree that accounts for the main patterns of vertical descent. However, the output of traditional consensus tree or supertree inference methods is a unique consensus tree or supertree.ResultsWe present a new efficient method for inferring multiple alternative consensus trees and supertrees to best represent the most important evolutionary patterns of a given set of gene phylogenies. We show how an adapted version of the popular k-means clustering algorithm, based on some remarkable properties of the Robinson and Foulds distance, can be used to partition a given set of trees into one (for homogeneous data) or multiple (for heterogeneous data) cluster(s) of trees. Moreover, we adapt the popular Caliński–Harabasz, Silhouette, Ball and Hall, and Gap cluster validity indices to tree clustering with k-means. Special attention is given to the relevant but very challenging problem of inferring alternative supertrees. The use of the Euclidean property of the objective function of the method makes it faster than the existing tree clustering techniques, and thus better suited for analyzing large evolutionary datasets.Availability and implementationOur KMeansSuperTreeClustering program along with its C++ source code is available at: https://github.com/TahiriNadia/KMeansSuperTreeClustering.Supplementary informationSupplementary data are available at Bioinformatics online.
Tau accelerates α-synuclein aggregation and spreading in Parkinson’s disease
Authors: Pan Lina , Li Chunrui , Meng Lanxia , Tian Ye , He Mingyang , Yuan Xin , Zhang Guoxin , Zhang Zhaohui , Xiong Jing , Chen Guiqin , Zhang Zhentao 
Published: May 2022

Abstract
The aggregation and prion-like propagation of α-synuclein are involved in the pathogenesis of Parkinson’s disease. However, the underlying mechanisms regulating the assembly and spreading of α-synuclein fibrils remain poorly understood. Tau co-deposits with α-synuclein in the brains of Parkinson’s disease patients, suggesting a pathological interplay between them.
Here we show that tau interacts with α-synuclein and accelerates its aggregation. Compared with pure α-synuclein fibrils, the tau-modified α-synuclein fibrils show enhanced seeding activity, inducing mitochondrial dysfunction, synaptic impairment and neurotoxicity in vitro. Injection of the tau-modified α-synuclein fibrils into the striatum of mice induces more severe α-synuclein pathology, motor dysfunction and cognitive impairment when compared with the mice injected with pure α-synuclein fibrils. Knockout of tau attenuates the propagation of α-synuclein pathology and Parkinson’s disease-like symptoms both in mice injected with α-syn fibrils and α-syn A53T transgenic mice.
In conclusion, tau facilitates α-synuclein aggregation and propagation in Parkinson’s disease.
Genetic mechanisms underlying gray matter volume changes in patients with drug-naive first-episode schizophrenia
Authors: Xu Xiaotao , Li Qian , Qian Yinfeng , Cai Huanhuan , Zhang Cun , Zhao Wenming , Zhu Jiajia , Yu Yongqiang 
Published: May 2022

AbstractBrain structural damage is a typical feature of schizophrenia. Investigating such disease phenotype in patients with drug-naive first-episode schizophrenia (DFSZ) may exclude the confounds of antipsychotics and illness chronicity. However, small sample sizes and marked clinical heterogeneity have precluded definitive identification of gray matter volume (GMV) changes in DFSZ as well as their underlying genetic mechanisms. Here, GMV changes in DFSZ were assessed using a neuroimaging meta-analysis of 19 original studies, including 605 patients and 637 controls. Gene expression data were derived from the Allen Human Brain Atlas and processed with a newly proposed standardized pipeline. Then, we used transcriptome–neuroimaging spatial correlations to identify genes associated with GMV changes in DFSZ, followed by a set of gene functional feature analyses. Meta-analysis revealed consistent GMV reduction in the right superior temporal gyrus, right insula and left inferior temporal gyrus in DFSZ. Moreover, we found that these GMV changes were spatially correlated with expression levels of 1,201 genes, which exhibited a wide range of functional features. Our findings may provide important insights into the genetic mechanisms underlying brain morphological abnormality in schizophrenia.
Radicalising Global IR: Modernity, Capitalism, and the Question of Eurocentrism
Authors: Duzgun Eren 
Published: May 2022

Abstract
Theorising a non-Eurocentric “global international relations” has been a main preoccupation of scholars associated with international political sociology (IPS). In this article, I argue that scholars within the IPS tradition have provided a powerful critique of, but no clear alternative to, Eurocentrism. This is partly attributable to their insufficient problematisation of the historical narratives that propel capitalism backwards into history. By problematising “presentist” conceptions of capitalism, I show that a critical dialogue between IPS and “political Marxism” helps to introduce an alternative foundation for anti-Eurocentrism, which shifts our focus from “capitalist modernity” to “radical modernity”. Radical modernity resists hierarchical colonial ontologies by emphasising the universality of egalitarian social patterns rooted in our common, non-capitalist past. I contend that radical modernity is an enduring legacy that is found universally, transmitted interactively, and revitalised continuously across time and space, hence providing an alternative base on which to theorise and globalise the “international” in a non-Eurocentric way.
NKG2D signaling regulates IL-17A-producing γδT cells in mice to promote cancer progression
Authors: Curio Sophie , Edwards Sarah C , Suzuki Toshiyasu , McGovern Jenny , Triulzi Chiara , Yoshida Nagisa , Jonsson Gustav , Glauner Teresa , Rami Damiano , Wiesheu Robert , Kilbey Anna , Violet Purcell Rachel , Coffelt Seth B , Guerra Nadia 
Published: May 2022

Abstract
γδT cells are unconventional T cells particularly abundant in mucosal tissues that play an important role in tissue surveillance, homeostasis, and cancer. γδT cells recognize stressed cells or cancer cells through the NKG2D receptor to kill these cells and maintain normality. Contrary to the well-established anti-tumor function of these NKG2D-expressing γδT cells, we show here that, in mice, NKG2D regulates a population of pro-tumor γδT cells capable of producing IL-17A. Germline deletion of Klrk1, the gene encoding NKG2D, reduced the frequency of γδT cells in the tumor microenvironment and delayed tumor progression. We further show that blocking NKG2D reduced the capability of γδT cells to produce IL-17A in the pre-metastatic lung and that co-culture of lung T cells with NKG2D ligand-expressing tumor cells specifically increased the frequency of γδT cells. Together, these data support the hypothesis that, in a tumor microenvironment where NKG2D ligands are constitutively expressed, γδT cells accumulate in an NKG2D-dependent manner and drive tumor progression by secreting pro-inflammatory cytokines, such as IL-17A.
A report from the Irish women in cardiology survey, exploring Europe’s largest gender gap in cardiology
Authors: Wong Bethany , Brennan Alice , James Stephanie , Brandon Lisa , Ranganathan Deepti , Dalton Barbra , McDonald Ken , Ward Deirdre 
Published: May 2022

Abstract

Aims
In Ireland, 8% of public cardiology consultants are female; this is the lowest proportion in Europe. We sought to understand perceptions amongst Irish trainees and consultants regarding aspects of working in cardiology in order to identify areas that can be targeted to improve gender equality.

Methods and Results
In September 2021, the Irish Cardiac Society distributed a questionnaire to trainees and consultants in the Republic and Northern Ireland. Ethical approval was obtained from the University College Dublin, Ireland. There were 94 respondents (50% male, 50% consultants) which equates to ∼30% of all trainees and consultants in all Ireland. Although females were more likely to be single, overall, they had additional child-care responsibilities compared with male counterparts. Despite 53% of the respondents preferring to work less than full time, 64% reported a perceived lack of support from their departments. Males were significantly more likely to go into procedural/high radiation sub-specialities. Bullying was reported by 53% of females. Almost 80% of females experienced sexism and 30% reported being overlooked for professional advancement based on their sex. Females also rated their career prospects lower than males. Key challenges for women were: sexism, maternity leave/child-care responsibilities, cardiology as a ‘boys club’ and lack of flexible training. There was interest from both males and females in a mentorship programme and support for women in leadership positions.

Conclusion
Discrimination including sexism, bullying, and equal opportunity for professional advancement are key aspects that need to be addressed to improve gender balance in cardiology within Ireland and Northern Ireland.
Paradoxical prolongation of QT interval during exercise in patients with hypertrophic cardiomyopathy: cellular mechanisms and implications for diastolic function
Authors: Coppini Raffaele , Beltrami Matteo , Doste Ruben , Bueno-Orovio Alfonso , Ferrantini Cecilia , Vitale Giulia , Pioner Josè Manuel , Santini Lorenzo , Argirò Alessia , Berteotti Martina , Mori Fabio , Marchionni Niccolò , Stefàno Pierluigi , Cerbai Elisabetta , Poggesi Corrado , Olivotto Iacopo 
Published: May 2022

Abstract

Aims
Ventricular cardiomyocytes from hypertrophic cardiomyopathy (HCM) patient hearts show prolonged action potential duration (APD), impaired intracellular Ca2+ homeostasis and abnormal electrical response to beta -adrenergic stimulation. We sought to determine whether this behaviour is associated with abnormal changes of repolarization during exercise and worsening of diastolic function, ultimately explaining the intolerance to exercise experienced by some patients without obstruction.

Methods and results
Non-obstructive HCM patients (178) and control subjects (81) underwent standard exercise testing, including exercise echocardiography. Ventricular myocytes were isolated from myocardial samples of 23 HCM and eight non-failing non-hypertrophic surgical patients. The APD shortening in response to high frequencies was maintained in HCM myocytes, while β-adrenergic stimulation unexpectedly prolonged APDs, ultimately leading to a lesser shortening of APDs in response to exercise. In HCM vs. control subjects, we observed a lesser shortening of QT interval at peak exercise (QTc: +27 ± 52 ms in HCM, −4 ± 50 ms in controls, P &lt; 0.0001). In patients showing a marked QTc prolongation (&gt;30 ms), the excessive shortening of the electrical diastolic period was linked with a limited increase of heart-rate and deterioration of diastolic function at peak effort.

Conclusions
Abnormal balance of Ca2+- and K+-currents in HCM cardiomyocytes determines insufficient APD and Ca2+-transient shortening with exercise. In HCM patients, exercise-induced QTc prolongation was associated with impaired diastolic reserve, contributing to the reduced exercise tolerance. Our results support the idea that severe electrical cardiomyocyte abnormalities underlie exercise intolerance in a subgroup of HCM patients without obstruction.
Evaluation of the atrial fibrillation better care pathway in the ENGAGE AF-TIMI 48 trial
Authors: Patel Siddharth M , Palazzolo Michael G , Murphy Sabina A , Antman Elliot M , Braunwald Eugene , Lanz Hans-Joachim , Lip Gregory Y H , Giugliano Robert P , Ruff Christian T 
Published: May 2022

Abstract

Aims
The Atrial fibrillation Better Care (ABC) pathway is endorsed by guidelines to improve care of patients with atrial fibrillation (AF). However, whether the benefit of ABC pathway-concordant care is consistent across anticoagulants remains unclear. We assessed the association between ABC-concordant care and outcomes in this post hoc analysis from the ENGAGE AF-TIMI 48 trial, which was reported prior to the initial description of the ABC pathway.

Methods and results
Patients were retrospectively classified as receiving ABC-concordant care based on optimal anticoagulation, adequate rate control, management of co-morbidities and lifestyle measures. Associations between ABC-concordance and outcomes were assessed with adjustment for components of the CHA2DS2-VASc and HAS-BLED scores. Of 20 926 patients, 7915 (37.8%) satisfied criteria of ABC-concordant care, which was associated with significantly lower incidence of stroke or systemic embolic event [stroke/SEE: hazard ratio (HRadj): 0.54; 95% confidence interval (CI): 0.47–0.63], major bleeding (HRadj 0.66; 95% CI: 0.58–0.75), major adverse cardiac events (HRadj 0.53; 95% CI: 0.48–0.58), primary net clinical outcome (composite of stroke/SEE, major bleeding or death; HRadj 0.61; 95% CI: 0.56–0.65), cardiovascular (CV) hospitalization (HRadj 0.78; 95% CI: 0.74–0.83), CV death (HRadj 0.52; 95% CI: 0.46–0.58), and all-cause mortality (HRadj 0.56; 95% CI: 0.51–0.62), P &lt; 0.001 for each. These associations were qualitatively consistent for both edoxaban and warfarin and across patient subgroups.

Conclusion
Atrial fibrillation Better Care pathway-concordant care is associated with reductions across multiple CV endpoints and all-cause mortality, with benefit in edoxaban- and warfarin-treated patients and across patient subgroups. Increasing implementation of ABC-concordant care may improve clinical outcomes of patients with AF irrespective of anticoagulant.
Antibiotic prescribing for upper respiratory tract infections and acute bronchitis: a longitudinal analysis of general practitioner trainees
Authors: Baillie Emma J , Merlo Gregory , Magin Parker , Tapley Amanda , Mulquiney Katie J , Davis Joshua S , Fielding Alison , Davey Andrew , Holliday Elizabeth , Ball Jean , Spike Neil , FitzGerald Kristen , van Driel Mieke L 
Published: May 2022

Abstract

Background
Most antibiotic prescribing for upper respiratory tract infections (URTIs) and acute bronchitis is inappropriate. Substantive and sustained reductions in prescribing are needed to reduce antibiotic resistance. Prescribing habits develop early in clinicians’ careers. Hence, general practice (GP) trainees are an important group to target.

Objectives
We aimed to establish temporal trends in antibiotic prescribing for URTIs and acute bronchitis/bronchiolitis by Australian GP trainees (registrars).

Methods
A longitudinal analysis, 2010–2019, of the Registrars Clinical Encounters in Training (ReCEnT) dataset. In ReCEnT, registrars record clinical and educational content of 60 consecutive consultations, on 3 occasions, 6 monthly. Analyses were of new diagnoses of URTI and acute bronchitis/bronchiolitis, with the outcome variable a systemic antibiotic being prescribed. The independent variable of interest was year of prescribing (modelled as a continuous variable).

Results
28,372 diagnoses of URTI and 5,289 diagnoses of acute bronchitis/bronchiolitis were recorded by 2,839 registrars. Antibiotic prescribing for URTI decreased from 24% in 2010 to 12% in 2019. Prescribing for acute bronchitis/bronchiolitis decreased from 84% to 72%. “Year” was significantly, negatively associated with antibiotic prescribing for both URTI (odds ratio [OR] 0.90; 95% confidence interval [CI]: 0.88–0.93) and acute bronchitis/bronchiolitis (OR 0.92; 95% CI: 0.88–0.96) on multivariable analysis, with estimates representing the mean annual change.

Conclusions
GP registrars’ prescribing for URTI and acute bronchitis/bronchiolitis declined over the 10-year period. Prescribing for acute bronchitis/bronchiolitis, however, remains higher than recommended benchmarks. Continued education and programme-level antibiotic stewardship interventions are required to further reduce registrars’ antibiotic prescribing for acute bronchitis/bronchiolitis to appropriate levels.