bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential Role of 68Ga-NOTA-Duramycin PET/CT Imaging for Early Response Evaluation in a Lymphoma Patient
Authors: Kaur Gurvinder , Shukla Jaya , Sood Ashwani , Prakash Gaurav , Krishnaraju Venkata Subramanian , Rana Nivedita , Pandey Somit , Singh Harmandeep , Kumar Rajender , Bal Amanjit , Mittal Bhagwant Rai 
Published: December 2022

Abstract
Duramycin, a 19 amino acids peptide, is known for its potential to target phosphatidylethanolamine. During cell death (apoptosis), rearrangement of membrane phospholipids results in the externalization of phosphatidylethanolamine to the outer leaflet of the cell membrane, which can be imaged using 68Ga-NOTA-duramycin. We report 68Ga-NOTA-duramycin imaging in a 50-year-old man with biopsy-proven diffuse large B-cell lymphoma planned for anthracycline-based chemotherapy. 68Ga-NOTA-duramycin PET/CT imaging along with 18F-FDG PET/CT was performed before and after 2 cycles of chemotherapy. The tracer avidity in interim 68Ga-NOTA-duramycin PET/CT showed its diagnostic potential to assess early response to chemotherapy.
7T Small Animal MRI Research for Hepatic Alveolar Echinococcosis
Authors: Zhang Guanmi , Mou Yalin , Fan Haining , Li Weixia , Cao Yuntai , Bao Haihua 
Published: December 2022

Abstract:

Objectives:
7T small animal magnetic resonance imaging (MRI) was used to analyze the growth characteristics of hepatic alveolar echinococcosis (HAE).

Methods:
A mouse model of HAE was established by intraperitoneal injection of alveolar Echinococcus tissue suspension. Ten mouse models successfully inoculated by ultrasound screening were selected. The mouse model was scanned with T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), and diffusion-weighted imaging (DWI) sequence by 7T small animal MRI. Size, morphology, boundary, signal, and relationship with surrounding tissues of the lesions were recorded as characteristic alterations. Mice were killed at the end of the experiment, and the pathological specimens were taken for routine hematoxylin and eosin staining.

Results:
Lesions were mainly located in the right lobe of the liver. The multivesicular structure is the characteristic manifestation of this disease. In the liver, lesions invaded the portal vein and were mainly distributed at the hepatic hilum. The left branch of the portal vein was mainly invaded. The mean diameter of the lesions in the left lobe of the liver was larger than in other parts of the liver. The mean diameter of the cystic solid lesions was greater than the multilocular cystic lesions. HAE showed hypointense on T1WI, hyperintense on T2WI, and hypointense on DWI; the marginal zone of the lesion showed hyperintensity on DWI and grew toward the hilum. The MRI features of intraperitoneal lesions were similar to those of intrahepatic lesions. Intraperitoneal lesions increased faster than intrahepatic lesions in the same period.

Conclusion:
Polyvesicular structure is a characteristic manifestation of hepatic alveolar echinococcosis in mice. The noninvasive monitoring of liver HAE in mice by 7T small animal MRI provides a visual basis for the diagnosis and treatment integration of HAE.
Comparative Study on Nosocomial Biliary Tract Infection Rate Between Biliary Stent Loaded with Radioactive 125I Seeds and Conventional Biliary Stent in the Treatment of Distal Malignant Biliary Obstruction
Authors: An Jianli , Dong Yanchao , Niu Hongtao , Li Yanguo , Han Xiaoyu , Zou Zibo , Wu Jingpeng , Tian Ye , Chen Zhuo 
Published: December 2022

Background:
The purpose of this prospective randomized study was to compare the nosocomial biliary tract infection rate of biliary stent implantation with a biliary stent loaded with radioactive 125I seeds (radioactive biliary stent, RBS) and conventional biliary stent (CBS); additionally, to preliminary discuss the causes of postoperative cholangitis. Moreover, the results will provide clinical evidence for the prevention of postoperative biliary tract infection.

Materials and Methods:
We prospectively analyzed the nosocomial infection rate of the distal malignant biliary obstruction (MBO) treatment by stent implantation with RBS and CBS. All MBO patients who initially visited our tertiary hospital between July 2015 and December 2019 (n= 196) were evaluated, enrolled, and randomly divided into 2 groups, RBS (n=97) and CBS (n=99) group. χ2 test was used to evaluate the categorical data, and t test was used to evaluate the numerical data.

Results:
Our analysis of the study showed the incidence of postoperative infections of a biliary tract of the RBS group (23.7%) was significantly higher than the CBS group (11.1%). The difference was statistically significant (χ2=5.425, P=0.020). Our study also showed the most common pathogenic bacteria after surgery was Escherichia coli (26.5%).

Conclusion:
Treatment for distal MBO with biliary stent loaded with radioactive 125I seeds had a higher nosocomial infection rate, and the most common pathogenic bacteria was E coli., Supplemental Digital Content 1, http://links.lww.com/sle/A350
The Role of Intraoperative Indocyanine Green (ICG) and Preoperative 3-Dimensional (3D) Reconstruction in Laparoscopic Adrenalectomy: A Propensity Score-matched Analysis
Authors: Palomba Giuseppe , Dinuzzi Vincenza Paola , Pegoraro Francesca , Troisi Roberto Ivan , Montalti Roberto , De Palma Giovanni Domenico , Aprea Giovanni 
Published: December 2022

Background:
Laparoscopic adrenalectomy (LA) is considered the “gold standard” treatment of adrenal lesions that are often coincidentally diagnosed during the radiologic workup of other diseases. This study aims to evaluate the intraoperative role of indocyanine green (ICG) fluorescence associated with preoperative 3-dimensional reconstruction (3DR) in laparoscopic adrenalectomy in terms of perioperative outcomes. To our knowledge, this is the first prospective case-controlled report comparing these techniques.

Materials and Methods:
All consecutive patients aged≥18 and undergoing laparoscopic transperitoneal adrenalectomy for all adrenal masses from January 1, 2019 to January 31, 2022 were prospectively enrolled. Patients undertaking standard LA and those undergoing preoperative 3D reconstruction and intraoperative ICG fluorescence were matched through a one-on-one propensity score matching analysis (PSM) for age, gender, BMI, CCI score, ASA score, lesion histology, tumor side, and lesion diameter. Differences in operative time, blood loss, intraoperative and postoperative complications, conversion rate, and length of stay were analyzed.

Results:
After propensity score matching analysis, we obtained a cohort of 36 patients divided into 2 groups of 18 patients each. The operative time and intraoperative blood loss were shorter in patients of the 3DR group (P=0,004 and P=0,004, respectively). There was no difference in terms of length of stay, conversion rate, and intraoperative and postoperative complications between the 2 groups.

Conclusions:
The use of intraoperative ICG in LA and preoperative planning with 3DR images is a safe and useful addition to surgery. Furthermore, we observed a reduction in terms of operating time and intraoperative blood loss.
Single-balloon Enteroscopy for Evaluation of Small Bowel Crohn Disease Strictures: Peripheral Blood Lymphocytes As a Risk Factor for Strictures
Authors: Zhang Juanjuan , Qian Xiaoli , Yan Wei , Diao Yanqing , Da Binlin , Shen Juanhong , Wang Zhiming , Zhu Weiming 
Published: December 2022

Background:
Few reports have focused on single-balloon enteroscopy (SBE) for evaluation of small bowel Crohn disease (CD) strictures. The aim of this study was to analyze the relationships between peripheral blood inflammatory markers and small bowel CD strictures observed by SBE.

Materials and Methods:
CD patients who underwent SBE between January 2016 and December 2020 were enrolled. The clinical characteristics and peripheral blood inflammatory markers were collected and analyzed to screen for predictive factors significantly associated with small bowel CD strictures.

Results:
A total of 221 CD patients underwent SBE. The lymphocyte (LC) counts in peripheral blood were significantly lower in the active group (n=178) than in the inactive group (n=43) according to the simple endoscopic score for CD (SES-CD), P=0.011, and was correlated with the SES-CD (r=−0.134, P=0.047). The LC levels were significantly lower in the stricture group (n=116) than in the nonstricture group (n=105) based on whether small bowel strictures developed, P=0.000, and LC was a risk factor for strictures in the multivariate analysis [hazard ratio (HR), 2.332; 95% CI, 1.102-4.937; P=0.027]. In the subgroup analysis, LC levels notably decreased after stricture aggravation (P=0.000). Forty-seven patients who underwent small bowel resection underwent SBE at 6 to 12 months after surgery. The LC level was significantly lower in the postoperative patients with strictures (P=0.025), and LC (HR, 4.444; 95% CI, 1.265-15.617; P=0.020) was a risk of postoperative strictures by univariate analysis, but the age at diagnosis (HR, 6.462; 95% CI, 1.272-22.560; P=0.022) was an independent risk factor by multivariate analysis.

Conclusion:
Peripheral blood LC levels were correlated with SES-CD and gradually decreased as the intestinal stricture increased in small bowel CD patients. The LC level was also significantly lower in the postoperative CD patients with strictures. The level of LC was a risk factor for small bowel strictures. These results suggest that peripheral blood LC could be a novel marker of small bowel CD strictures to guide CD diagnosis and therapy.
Role of quantum fluctuation in inducing ergodicity in the spin glass phase and its effect in quantum annealing
Authors: Mukherjee Sudip 
Published: December 2022

We review the numerical studies on the critical behaviour of the quantum Sherrington–Kirkpatrick (SK) spin glass model, which indicate that a quantum critical behaviour is observed up to a low but non-zero value of temperature. We revisit the numerical investigations on the spin glass order parameter distributions, which identify a low temperature along with high transverse field spin glass phase where the order parameter distribution becomes a delta function in the thermodynamic limit indicating the restoration of replica symmetry and ergodic nature of the system. In the remaining spin glass phase associated with high temperature and low transverse field, the observed distribution is broad akin to the Parisi order parameter distribution. This essentially indicates the non-ergodic behaviour of the system. We further discuss the annealing dynamics studies on the quantum SK model. Such investigations reveal the system size independence of annealing time when the annealing paths go through the ergodic spin glass region. Interestingly, when such dynamics are performed in the non-ergodic spin glass phase the annealing time becomes an increasing function of the system size. Spin autocorrelation shows faster relaxation in the ergodic spin glass region compared with that found in the non-ergodic spin glass region.
This article is part of the theme issue ‘Quantum annealing and computation: challenges and perspectives’.
Understanding domain-wall encoding theoretically and experimentally
Authors: Berwald Jesse , Chancellor Nicholas , Dridi Raouf 
Published: December 2022

We analyse the method of encoding pairwise interactions of higher-than-binary discrete variables (these models are sometimes referred to as discrete quadratic models) into binary variables based on domain walls on one-dimensional Ising chains. We discuss how this is relevant to quantum annealing, but also many gate model algorithms such as VQE and QAOA. We theoretically show that for problems of practical interest for quantum computing and assuming only quadratic interactions are available between the binary variables, it is not possible to have a more efficient general encoding in terms of number of binary variables per discrete variable. We furthermore use a D-Wave Advantage 1.1 flux qubit quantum annealing computer to show that the dynamics effectively freeze later for a domain-wall encoding compared with a traditional one-hot encoding. This second result could help explain the dramatic performance improvement of domain wall over one-hot, which has been seen in a recent experiment on D-Wave hardware. This is an important result because usually problem encoding and the underlying physics are considered separately, our work suggests that considering them together may be a more useful paradigm. We argue that this experimental result is also likely to carry over to a number of other settings, we discuss how this has implications for gate-model and quantum-inspired algorithms.
This article is part of the theme issue ‘Quantum annealing and computation: challenges and perspectives’.
Development of research network on Quantum Annealing Computation and Information using Google Scholar data
Authors: Sinha Antika 
Published: December 2022

We build and analyse the network of 100 top-cited nodes (research papers and books from Google Scholar; the strength or citation of the nodes range from about 44 000 up to 100) starting in early 1980 until last year. These searched publications (papers and books) are based on Quantum Annealing Computation and Information categorized into four different sets: (A) Quantum/Transverse Field Spin Glass Model, (B) Quantum Annealing, (C) Quantum Adiabatic Computation and (D) Quantum Computation Information in the title or abstract of the searched publications. We fitted the growth in the annual number of publication (np) in each of these four categories, A–D, to the formnp∼exp⁡(t/τ),wheretdenotes the time in years. We found the scaling timeτto be of the order of about 10 years for categories A and C, whereasτis of the order of about 5 years for categories B and D.This article is part of the theme issue ‘Quantum annealing and computation: challenges and perspectives’.
Is the Public Ready for a Tobacco-Free Ireland? A National Survey of Public Knowledge and Attitudes to Tobacco Endgame in Ireland
Authors: Cosgrave Ellen , Blake Martina , Murphy Edward , Sheridan Aishling , Doyle Frank , Kavanagh Paul 
Published: December 2022

AbstractTobacco-Free Ireland (TFI) policy sets a tobacco endgame goal to reduce smoking prevalence to less than 5% by 2025. However, public opinion on this goal, an important policy lever, is uncharted in Ireland. This study aimed to inform policy planning by measuring public knowledge and attitudes to tobacco endgame.A telephone-administered cross-sectional survey of 1,000 randomly-dialled members of the general public was conducted. Prevalence of awareness, perceived achievability, and support for the TFI goal and potential tobacco endgame measures was calculated and compared across tobacco/e-cigarette user status. Logistic regression identified factors independently associated with TFI goal support.Although TFI goal awareness was low (34.0%), support was high (74.6%), albeit most (60.2%) believed it achievable beyond 2025. Goal support was higher among non-tobacco/e-cigarette users (adjusted Odds Ratio (aOR) 2.68, 95%CI 1.83-3.90), women (aOR 1.55, 95%CI 1.13-2.14) and higher social class members (aOR 1.48, 95%CI 1.03-2.12). Product-focused measures were popular while views on user-focused measures were mixed: e.g. 86.1% supported nicotine content reduction while 40.3% supported user licensing. Phasing-out tobacco sales was highly-supported (82.8%); however, for most, this was contingent on support for currently addicted users.Despite low awareness, there is strong support for tobacco endgame in Ireland and views on achievability are more realistic than the current goal of 2025. Supporting currently addicted tobacco users and engaging groups with lower support will be important policy planning and communication considerations. The Irish public are ready for tobacco endgame. These findings should re-invigorate policy planning to translate endgame ambition into action.
Bucillamine use for rheumatoid arthritis and type 2 diabetes mellitus are associated with neural epidermal growth factor-like 1 (NELL1)-associated membranous nephropathy
Authors: Tsuji Takahiro , Iwasaki Sari , Makita Keishi , Furukawa Shota , Watanabe-Kusunoki Kanako , Takeda-Otera Sayo , Itoh Takahito , Shimamoto Mamiko , Yamaji Hiroaki , Yoshimura Tomomasa , Yamamoto Junya , Kudo Takashi , Kondo Makoto , Kataoka Hiroshi , Mukai Masaya , Kaga Yukito , Yoshinari Miku , Nishibata Yuka , Masuda Sakiko , Tomaru Utano , Ishizu Akihiro , Fukasawa Yuichiro , Hashimoto Seiji , Nishio Saori 
Published: December 2022

AbstractMembranous nephropathy (MN) is a disease characterized by deposition of immune complexes on the glomerular basement membrane. More than 10 specific antigens for MN including M-type phospholipase A2 receptor (PLA2R), thrombospondin type-1 domain-containing 7A (THSD7A), exostosin 1/exostosin 2 (EXT1/EXT2) and neural epidermal growth factor-like 1 (NELL1) have so far been identified. Since the clinicopathologic characteristics of each type of MN in Japanese are not well understood, we first examined 107 cases of MN by immunohistochemistry for four antigens (PLA2R, THSD7A, EXT1, and NELL1) (MN-cohort). Of those 107 cases, 40% were PLA2R-positive, 13% were NELL1-positive, 11% were THSD7A-positive, 5% were EXT1-positive, 2% were PLA2R and NELL1-double-positive, and 29% were quadruple-negative. In one case of PLA2R and NELL1-double-positive, the first biopsy showed PLA2R-positive and the second biopsy showed PLA2R and NELL1-double-positive. Of the 16 cases of NELL1-positive, 12.5% had colon cancer, 18.8% had rheumatic diseases treated with bucillamine, and 63% had type 2 diabetes mellitus (T2DM). Next, 34 patients diagnosed with MN who had rheumatoid arthritis (RA) were examined (RA-MN cohort). Of those 34 patients, 79% were NELL1-positive, 6% were PLA2R-positive, and 15% were quadruple-negative. In the RA-MN cohort, 56% had a history of bucillamine use. In conclusion, NELL1-associated MN is a common MN in patients with RA using bucillamine and may also be associated with T2DM.
The vascular geneApold1is dispensable for normal development but controls angiogenesis under pathological conditions
Authors: Fan Zheng , Ardicoglu Raphaela , Batavia Aashil A. , Rust Ruslan , von Ziegler Lukas , Waag Rebecca , Zhang Jing , Desgeorges Thibaut , Sturman Oliver , Dang Hairuo , Weber Rebecca , Moor Andreas E. , Schwab Martin E. , Germain Pierre-Luc , Bohacek Johannes , Bock Katrien De 
Published: December 2022

AbstractThe molecular mechanisms of angiogenesis have been intensely studied, but many genes that control endothelial behavior and fate still need to be described. Here, we characterize the role ofApold1(Apolipoprotein L domain containing 1) in angiogenesisin vivoandin vitro. Single-cell analyses reveal that - across tissues - the expression ofApold1is restricted to the vasculature, and thatApold1expression in endothelial cells (ECs) is highly sensitive to environmental factors. UsingApold1-/-mice, we find thatApold1is dispensable for development and does not affect postnatal retinal angiogenesis nor alters the vascular network in adult brain and muscle. However, when exposed to ischemic conditions following photothrombotic stroke as well as femoral artery ligation,Apold1-/-micedisplay dramatic impairments in recovery and revascularization. We also find that human tumor endothelial cells express strikingly higher levels ofApold1,and thatApold1deletion in mice stunts the growth of subcutaneous B16 melanoma tumors, which have smaller and poorly perfused vessels. Mechanistically,Apold1is activated in ECs upon growth factor stimulation as well as in hypoxia, andApold1intrinsically controls EC proliferation but not migration. Our data demonstrate thatApold1is a key regulator of angiogenesis in pathological settings, whereas it does not affect developmental angiogenesis, thus making it a promising candidate for clinical investigation.
Microbial symbionts are shared between ants and their associated beetles
Authors: Valdivia Catalina , Newton Justin A. , O’Donnell Sean , von Beeren Christoph , Kronauer Daniel J. C. , Russell Jacob A. , Łukasik Piotr 
Published: December 2022

AbstractThe transmission of microbial symbionts across individuals and generations can be critical for animal development and survival. Likewise, the transmission of microbes across closely interacting species could also affect host biology. Army ants (Formicidae: Dorylinae) and their hundreds of closely associated insect species (myrmecophiles) can provide a unique insight into interspecific symbiont sharing. Here, we compared the microbiota of workers and larvae of the army antEciton burchelliiwith those of 13 myrmecophile beetle species using 16S rRNA amplicon sequencing. We found that the previously characterized symbionts of army ant workers (Unclassified Firmicutes and Unclassified Entomoplasmatales) were largely absent from ant larvae and from myrmecophiles, whose microbial communities were usually dominated byRickettsia, Wolbachia, Rickettsiella, and/orWeissella. Strikingly, different species of myrmecophiles and ant larvae often shared identical 16S rRNA genotypes of common bacteria. In particular, army ant larvae, some workers, and several myrmecophile species often hosted identicalWeissella(Lactobacillales), based on 16S rRNA and also protein-coding gene sequences. Also, we found high relatedness between some newly characterizedWeissellaand animal-associated strains from aquatic and marine habitats. Looking more broadly, we foundWeissellaOTUs in 11.6% of samples from nearly all habitats and environments characterized by the Earth Microbiome Project. Together, our data show that unrelated but closely interacting species can share much of their microbiota. The high relatedness of strains found across such disparate hosts as ants, beetles, trout, and whales suggests that some versatile microbes move between hosts and habitats despite few opportunities for direct interaction.
Clinical andIn SituCharacterization of Hepatitis Delta Virus in Sjogren’s Syndrome
Authors: Hesterman Matthew C. , Furrer Summer V. , Fallon Braden S. , Weller Melodie L. 
Published: December 2022

AbstractHepatitis delta virus (HDV) has been detected in the minor salivary gland (MSG) tissue of Sjogren’s Syndrome (SjS) patients in the absence of an HBV co-infection. HDV antigen expression was previously shown to trigger an SjS-like phenotype in vivo, demonstrating a cause-and-effect association. We hypothesize that if HDV regulates SjS development, then HDV profiles may correlate with disease manifestations. This retrospective study characterized HDV in a cohort of 48 SjS MSG between 2014-2021. Analyses of HDV antigen (HDAg) expression, including cell type and subcellular localization,in situhybridization of HDV RNA, and comparative analyses with associated SjS and viral hepatitis clinical features were conducted. HDAg was detected in MSG acinar, ductal, and adipose cells. HDAg localized with nuclei and mitochondria. HDV genomic RNA localized to the nucleus. A significant negative correlation was noted between HDAg intensity and focal lymphocytic inflammation. No significant associations were detected between MSG-localized HDAg and liver enzymes, or an evident HBV co-infection. This study has identified a non-hepatic reservoir for chronic HDV persistence in SjS-affected MSG and a unique mitochondrial localization for HDV antigen. Detection of non-hepatic HDV-mediated disease in the absence of an evident current or past HBV co-infection warrants further investigation.