bluuebunny/crossref_metadata_2025_split huggingface dataset:
(Invited, Digital Presentation) Application of Polyacid Clusters in Modifying Single-Walled Carbon Nanotubes
Authors: Li Yan 
Published: July 2022

Phosphotungstic acids (PTAs) are a typical family of polyacids with tunable composition, structure and morphology. Relying on their super strong acidity and moderate oxidizability, they may take different roles when interacting with single walled carbon nanotubes (SWCNTs).
We found that PTA could be used as stable dopants for SWCNT films to reduce the resistance without damaging the transparency. By simply dipping the SWCNT films in the solution of PTAs and drying afterwards, the sheet resistance was cut in half with long term stability. The doped films showed excellent flexibility. Both Raman spectroscopic studies and Kelvin probe force microscopy measurements revealed that the strong acidity of PTAs plays a key role in the doping effect by increasing the redox potential of the ambient O2 and thus the Fermi level of the SWCNTs is brought down.
The PTA clusters can be encapsulated into the inner cavity of SWCNTs when their diameters are compatible. Such a host-guest molecular interaction between SWCNTs and inner clusters with designed size was applied to separate large-diameter s-SWCNTs. When a kind of PTA of ~1 nm in size were filled within SWCNT cavities, s-SWCNTs with diameters concentrated at ~1.3–1.4 nm were selectively extracted with the purity of ~98% by a commercially available polyfluorene derivative. The sorting mechanisms associate with oxidation effect of PTA and the size-dependent electron transfer from nanotubes to inner PTA clusters. The flexible regulation of interaction between the nanotube and clusters, thus tuning the diameter of sorted s-SWCNTs.
PTAs have shown great power in tuning the properties of SWCNTs, presenting amazing potentials in the applications of SWCNTs.
(Invited) Synthesis and Application of One-Dimensional Van Der Waals Heterostrucures Based on Single-Walled Carbon Nanotubes
Authors: Maruyama Shigeo 
Published: July 2022

A typical one-dimensional (1D) van der Waals (vdW) heterostructure consists of single-walled carbon nanotubes (SWCNT), boron nitride nanotube (BNNT), and molybdenum disulfide nanotube (MoS2NT), can be grown coaxially by successive chemical vapor deposition (CVD) steps [1]. The coaxially nested structure based on SWCNTs can expand the board application possibilities of 1D vdW heterostructures [2]. Semiconductor SWCNT wrapped with BNNT can be regarded as the ideal building blocks of field-effect transistors (FET) [3]. We have demonstrated the radial semiconductor–insulator–semiconductor (S-I-S) tunneling heterojunction diode by using a micrometer long 1D vdW heterostructure SWCNT@BNNT@MoS2NT [4]. By comparing optical properties of films of BNNT@MoS2NT and SWCNT@BNNT@MoS2NT, we found strong photoluminescence (PL) from monolayer MoS2NT and quenching of PL by coupling to SWCNT through thin BNNT [5]. The remarkable population of free charges and inter-tube excitons are demonstrated by ultrafast optical spectroscopy [6]. The inter-tube excition is regarded as the inter-layer excition for 2D heterostructures. Precise control of the chemical vapor deposition (CVD) process of each layer is essential since the mechanical exfoliation & stacking technique for 2D counterpart is not possible for 1D vdW heterostructures. The surprisingly sharp edge of BNNT grown on SWCNT is the signature of preference of nitrogen terminated zig-zag edge of h-BN common to 2D counterpart [7]. The next challenge is the CVD growth of various transition metal dichalcogenides on BNNTs. In addition to MoS2 nanotubes [1], we will discuss the growth control of WS2 nanotubes and NbS2 nanotubes. A general strategy we can tune the CVD condition from 2D flake to 1D tube is proposed [8].
Part of this work was supported by JSPS KAKENHI Grant Number JP20H00220, and by JST, CREST Grant Number JPMJCR20B5, Japan.
References
[1] R. Xiang, et al., Science, 367 (2020) 537.
[2] S. Cambré, et al., Small, 17 (2021) 2102585.
[3] R. Xiang, S. Maruyama, Small Sci., 1 (2021) 2000039.
[4] Y. Feng, et al., ACS Nano, 15 (2021) 5600.
[5] M. Liu, et al., ACS Nano, 15 (2021) 8418.
[6] M. G. Burdanova, et al., Adv. Funct. Mater., 9 (2021) 2104969.
[7] Y. Zheng, et al, P. Natl. Acad. Sci., 118 (2021) e2107295118.
[8] Y. Zheng, et al, to be submitted.
(Invited) Kinetics and Thermodynamics of Swcnts and Bnnts Encapsulation with α-Sexithiophene in Liquid Phase
Authors: Allard Charlotte , Desjardins Patrick , Gaufres Etienne , Martel Richard 
Published: July 2022

Single-Walled Carbon Nanotubes (SWNTs) and Boron Nitride Nanotubes (BNNTs) come with hollow 1D centers, which can serve to define narrow spaces for encapsulating small organic dyes. The encapsulation process is of scientific interest because it can be used to tailor the optical properties of the resulting dyes@NTs nanohybrids. Past works have shown that the dyes@SWCNT exhibits a strongly enhanced Raman scattering cross section, while the dyes@BNNTs do emit robust, generally red-shifted, luminescence at wavelengths down to the near-IR. In both cases, the nanotube protects the encapsulated dyes from photobleaching, provides high confinement, and reinforces intermolecular interactions between dyes into specific aggregation states.
Here, we compare the liquid phase encapsulation process of α-sexithiophene (6T), which is a conjugated rod-like dye, inside SWCNTs and BNNTs. Raman and luminescence imaging experiments are used to monitor the 6T encapsulation process of a large ensemble of individual nanotubes in liquid-phase. This method probes statistically the encapsulation kinetics using hundreds of individual nanotubes according to various parameters (dye concentration and temperature). The results highlight a kinetic model in which single and double aggregates is formed sequentially. This kinetics and the associated thermodynamic parameters for the 6T encapsulation will be presented and discussed so as to gain a better control over the emission properties of the nanohybrids.
(Invited) Quantum Emission Assisted By Energy Landscape Modification in Pentacene-Decorated Carbon Nanotubes
Authors: Li Zhen , Otsuka Keigo , Yamashita Daiki , Kozawa Daichi , Kato Yuichiro K. 
Published: July 2022

Photoluminescent carbon nanotubes are expected to become versatile room-temperature single-photon sources that have applications in quantum information processing. Quantum emission from carbon nanotubes is often induced by localization of excitons or exciton-exciton annihilation. Here, we modify the local energy landscape of excitons by decorating nanoscale pentacene particles onto air-suspended single-walled carbon nanotubes [1]. Directional exciton diffusion from the undecorated region to the decorated site is demonstrated, suggesting exciton trapping induced by local dielectric screening from pentacene particles. Photoluminescence and photon correlation measurements on a representative carbon nanotube reveal enhanced exciton-exciton annihilation and single-photon emission at room temperature. Pentacene particles are shown to promote strong photon antibunching at the decorated site, indicating that noncovalent functionalization using molecules can be an effective approach for energy landscape modification and quantum emission in carbon nanotubes.
Work supported in part by MIC (SCOPE 191503001), JSPS (KAKENHI JP20H02558, JP19J00894, JP20J00817, JP20K15121, JP20K15137, JP20K15112 and JP20K15199), and MEXT (Nanotechnology Platform JPMXP09F19UT0079). K.O. and D.Y. are supported by the JSPS Research Fellowship. D.K. is supported by the RIKEN Special Postdoctoral Researcher Program. We acknowledge RIKEN Materials Characterization Team for access to the transmission electron microscope, and RIKEN Advanced Manufacturing Support Team for technical assistance.
[1] Z. Li, K. Otsuka, D. Yamashita, D. Kozawa, Y. K. Kato, ACS Photonics 8, 2367 (2021).
(Invited) Nanoelectronics Based on Assembled High-Density and High-Semiconducting-Purity Carbon Nanotube Films
Authors: Zhou Chongwu 
Published: July 2022

Carbon nanotubes hold great promise for high-performance electronics but also face significant challenges in terms of assembly and integration. On one hand, aligned carbon nanotubes are proposed as an alternative to III-V semiconductor technologies in radio frequency (RF) applications because of their high linearity as amplifiers and compatibility with CMOS electronics. We will first report high-performance RF transistors with operation frequencies beyond 100 GHz. These devices are built upon high-density (~50 nanotubes / micron) and high semiconducting purity (> 99.99%) aligned single-wall carbon nanotube films assembled at wafer scale. With gate length ~110 nm and T-shaped gate to reduce the gate charging resistance, the devices showed an extrinsic cutoff frequency and maximum oscillation frequency of over 100 GHz. The performance surpasses the 90 GHz cutoff frequency of radio-frequency CMOS transistors with gate length of 100 nm and is close to the performance of GaAs technology. [1] On the other hand, Carbon nanotubes are ideal candidates for beyond-silicon nanoelectronics because of their high mobility and low-cost processing; however, n-type transistors based on assembled aligned nanotubes has not been reported yet. Fabrication of n-type behavior field effect transistors (FETs) based on assembled aligned CNT arrays is needed for advanced CNT electronics. We will report a scalable process to make n-type transistors based on assembled aligned CNT arrays. Air-stable and high-performance n-type CNT FETs are achieved with high yield by combining atomic layer deposition dielectric and Ti contacts with gold overcoating, which are stable in air and widely used for III-V semiconductors. We also systematically studied the contribution of metal contacts and atomic layer deposition passivation in determining the transistor polarity. [2] Based on these experimental results, we report the successful demonstration of complementary metal-oxide-semiconductor inverters with good performance, which paves the way to realizing the promising future of carbon nanotube nanoelectronics.
[1] “Wafer-scalable, aligned carbon nanotube transistors operating at frequencies of over 100 GHz”, C. Rutherglen, A. A. Kane, P. F. Marsh, T. A. Cain, B. I. Hassan, M. R. AlShareef, C. Zhou and K. Galatsis, Nature Electronics, volume 2, pages 530–539, 2019.
[2] “Air-Stable n-Type Transistors based on Assembled Aligned Carbon Nanotube Arrays and Their Application in CMOS Electronics”, Z. Li, K. R. Jinkins, D. Cui, M. Chen, Z. Zhao, M. S. Arnold and C. Zhou, Nano Res. (2021). https://doi.org/10.1007/s12274-021-3567-9.
Genetic Risk of Second Primary Cancer in Breast Cancer Survivors: The Multiethnic Cohort Study
Authors: Chen Fei , Park Sungshim L. , Wilkens Lynne R. , Wan Peggy , Hart Steven N. , Hu Chunling , Yadav Siddhartha , Couch Fergus J. , Conti David V. , de Smith Adam J. , Haiman Christopher A. 
Published: July 2022

Abstract

Women who have had breast cancer in the past are at increased risk of developing a second primary cancer (SPC), including second primary breast cancer (SPBC) or a second primary non-breast cancer (SPNBC). In the Multiethnic Cohort (MEC) Study, we conducted a prospective cohort analysis in 3,223 female breast cancer survivors from five racial/ethnic populations (White, African American, Japanese American, Latino, and Native Hawaiian) to assess the association of rare pathogenic variants (PV) in 37 known cancer predisposition genes with risk of SPC. A total of 719 (22.3%) women developed SPC, of which, 323 (10.0%) were SPBC. Germline PVs in BRCA1 (HR, 2.28; 95% CI, 1.11–4.65) and ERCC2 (HR, 3.51; 95% CI, 1.29–9.54) were significantly enriched in women with SPC. In the subtype analysis for SPBC, a significant association of ERCC2 PVs (HR, 5.09; 95% CI, 1.58–16.4) and a suggestive association of BRCA2 PVs (HR, 2.24; 95% CI, 0.91–5.55) were observed. There was also a higher risk of SPNBC in carriers of BRCA1 PVs (HR, 2.98; 95% CI, 1.21–7.36). These results provide evidence that germline PVs in BRCA1, BRCA2, and ERCC2 contribute to the development of SPC in breast cancer survivors. These findings also suggest that compromised DNA repair mechanisms could be a predisposition factor for SPC in patients with breast cancer, supporting the need for closer monitoring of SPC in women carrying PVs in these genes.

Significance:
This multiethnic study links germline pathogenic variants in BRCA1, BRCA2, and ERCC2 to the development of second primary cancer in breast cancer survivors, providing biological insights and biomarkers to guide patient monitoring.
Comprehensive Serum Proteome Profiling of Cytokine Release Syndrome and Immune Effector Cell–Associated Neurotoxicity Syndrome Patients with B-Cell ALL Receiving CAR T19
Authors: Diorio Caroline , Shraim Rawan , Myers Regina , Behrens Edward M. , Canna Scott , Bassiri Hamid , Aplenc Richard , Burudpakdee Chakkapong , Chen Fang , DiNofia Amanda M. , Gill Saar , Gonzalez Vanessa , Lambert Michele P. , Leahy Allison Barz , Levine Bruce L. , Lindell Robert B. , Maude Shannon L. , Melenhorst J. Joseph , Newman Haley , Perazzelli Jessica , Seif Alix E. , Lacey Simon F. , June Carl H. , Barrett David M. , Grupp Stephan A. , Teachey David T. 
Published: July 2022

Abstract

Purpose:
To study the biology and identify markers of severe cytokine release syndrome (CRS) and immune effector cell–associated neurotoxicity syndrome (ICANS) in children after chimeric antigen receptor T-cell (CAR T) treatment.

Experimental Design:
We used comprehensive proteomic profiling to measure over 1,400 serum proteins at multiple serial timepoints in a cohort of patients with B-cell acute lymphoblastic leukemia treated with the CD19-targeted CAR T CTL019 on two clinical trials.

Results:
We identified fms-like tyrosine kinase 3 (FLT3) and mast cell immunoglobulin-like receptor 1 (MILR1) as preinfusion predictive biomarkers of severe CRS. We demonstrated that CRS is an IFNγ-driven process with a protein signature overlapping with hemophagocytic lymphohistiocytosis (HLH). We identified IL18 as a potentially targetable cytokine associated with the development of ICANS.

Conclusions:
We identified preinfusion biomarkers that can be used to predict severe CRS with a sensitivity, specificity, and accuracy superior to the current gold standard of disease burden. We demonstrated the fundamental role of the IFNγ pathway in driving CRS, suggesting CRS and carHLH are overlapping rather than distinct phenomena, an observation with important treatment implications. We identified IL18 as a possible targetable cytokine in ICANS, providing rationale for IL18 blocking therapies to be translated into clinical trials in ICANS.
Anticancer Activity of the Combination of Cabozantinib and Temozolomide in Uterine Sarcoma
Authors: Noh Joseph J. , Cho Young-Jae , Ryu Ji-Yoon , Choi Jung-Joo , Hwang Jae Ryoung , Choi Ju-Yeon , Lee Jeong-Won 
Published: July 2022

Abstract

Purpose:
To evaluate the anticancer effects of cabozantinib, temozolomide, and their combination in uterine sarcoma cell lines and mouse xenograft models.

Experimental Design:
Human uterine sarcoma cell lines (SK-LMS-1, SK-UT-1, MES-SA, and SKN) were used to evaluate the anticancer activity of cabozantinib, temozolomide, and their combination. The optimal dose of each drug was determined by MTT assay. Cell proliferation and apoptosis were assessed 48 and 72 hours after the drug treatments. The tumor weights were measured in an SK-LMS-1 xenograft mouse model and a patient-derived xenograft (PDX) model of leiomyosarcoma treated with cabozantinib, temozolomide, or both.

Results:
Given individually, cabozantinib and temozolomide each significantly decreased the growth and viability of cells. This inhibitory effect was more pronounced when cabozantinib (0.50 μmol/L) and temozolomide (0.25 or 0.50 mmol/L) were co-administered (P &lt; 0.05). The combination of the drugs also significantly increased apoptosis in all cells. Moreover, this effect was consistently observed in patient-derived leiomyosarcoma cells. In vivo studies with SK-LMS-1 cell xenografts and the PDX model with leiomyosarcoma demonstrated that combined treatment with cabozantinib (5 mg/kg/d, per os administration) and temozolomide (5 mg/kg/d, per os administration) synergistically decreased tumor growth (both P &lt; 0.05).

Conclusions:
The addition of cabozantinib to temozolomide offers synergistic anticancer effects in uterine sarcoma cell lines and xenograft mouse models, including PDX. These results warrant further investigation in a clinical trial.
GITR Antibodies in Cancer: Not Ready for Prime Time
Authors: Hernandez-Guerrero Tatiana , Moreno Victor 
Published: July 2022

Summary
Glucocorticoid-induced TNF receptor (TNFR)-related protein (GITR) agonistic antibodies are expected to increase the antitumor response mainly by reducing the effect of Foxp3+ T-regulatory cells. TRX-518 is a novel GITR agonist that has shown good pharmacodynamic activity by depleting regulatory T cells (Tregs) in preclinical models, with limited clinical activity demonstrated in patients with advanced solid tumors.
See related article by Davar et al., p. 3990
EPAC Regulates Melanoma Growth by Stimulating mTORC1 Signaling and Loss of EPAC Signaling Dependence Correlates with Melanoma Progression
Authors: Krishnan Aishwarya , Bhasker Aishwarya I. , Singh Mithalesh K. , Rodriguez Carlos. I. , Pérez Edgardo Castro , Altameemi Sarah , Lares Marcos , Khan Hamidullah , Ndiaye Mary , Ahmad Nihal , Schieke Stefan M. , Setaluri Vijayasaradhi 
Published: July 2022

Abstract

Exchange proteins directly activated by cAMP (EPAC) belong to a family of RAP guanine nucleotide exchange factors (RAPGEF). EPAC1/2 (RAPGEF3/4) activates RAP1 and the alternative cAMP signaling pathway. We previously showed that the differential growth response of primary and metastatic melanoma cells to cAMP is mediated by EPAC. However, the mechanisms responsible for this differential response to EPAC signaling are not understood. In this study, we show that pharmacologic inhibition or siRNA-mediated knockdown of EPAC selectively inhibits the growth and survival of primary melanoma cells by downregulation of cell-cycle proteins and inhibiting the cell-cycle progression independent of ERK1/2 phosphorylation. EPAC inhibition results in upregulation of AKT phosphorylation but a downregulation of mTORC1 activity and its downstream effectors. We also show that EPAC regulates both glycolysis and oxidative phosphorylation, and production of mitochondrial reactive oxygen species, preferentially in primary melanoma cells. Employing a series of genetically matched primary and lymph node metastatic (LNM) melanoma cells, and distant organ metastatic melanoma cells, we show that the LNM and metastatic melanoma cells become progressively less responsive and refractory to EPAC inhibition suggesting loss of dependency on EPAC signaling correlates with melanoma progression. Analysis of The Cancer Genome Atlas dataset showed that lower RAPGEF3, RAPGEF4 mRNA expression in primary tumor is a predictor of better disease-free survival of patients diagnosed with primary melanoma suggesting that EPAC signaling facilitates tumor progression and EPAC is a useful prognostic marker. These data highlight EPAC signaling as a potential target for prevention of melanoma progression.

Implications:
This study establishes loss of dependency on EPAC-mTORC1 signaling as hallmark of primary melanoma evolution and targeting this escape mechanism is a promising strategy for metastatic melanoma.
Suppressed Cellular Senescence Mediated by T-box3 in Aged Gastric Epithelial Cells may Contribute to Aging-related Carcinogenesis
Authors: Takeuchi Akio , Asano Naoki , Imatani Akira , Saito Masashi , Jin Xiaoyi , Saito Masahiro , Kanno Takeshi , Hatta Waku , Uno Kaname , Koike Tomoyuki , Masamune Atsushi 
Published: July 2022

Aging is a risk factor for cancers in various organs. Recent advances in the organoid culturing system have made it viable to investigate the influence of aging utilizing these mini organs. In this study, we aimed to examine the implications of aging for gastric carcinogenesis. Gastric organoids established from aged mice grew larger, proliferated vigorously, and survived longer than that from young mice. Because Wnt/β-catenin signaling was intensified in the aged organoids and because removal of Wnt-related factors diminished their proliferation, we investigated for Wnt target gene that contributed to enhanced proliferation and discovered that the aged organoids expressed the transcription factor T-box3 (Tbx3), which has been reported to suppress cellular senescence. Indeed, cellular senescence was suppressed in the aged organoids, and this resulted from enhanced G2–M transition. As for the mechanism involved in the intensified Wnt/β-catenin signaling, we identified that Dickkopf3 (Dkk3) expression was reduced in the aged organoids due to methylation of the Dkk3 gene. Finally, the expression of TBX3 was enhanced in human atrophic gastritis and even more enhanced in human gastric cancers. In addition, its expression correlated positively with patients’ age. These results indicated that the emergence of antisenescent property in aged gastric organoids due to enhanced Tbx3 expression led to accelerated cellular proliferation and organoid formation. Because the enhanced Tbx3 expression seen in aged gastric organoids was also observed in human gastric cancer tissues, this Dkk3-Wnt-Tbx3 pathway may be involved in aging-related gastric carcinogenesis.Significance:This work provides an insight into the mechanism involved in aging-related gastric carcinogenesis through studies utilizing organoids established from young and aged murine stomachs.
Limited Effect of Y Chromosome Variation on Coronary Artery Disease and Mortality in UK Biobank—Brief Report
Authors: Timmers Paul R.H.J. , Wilson James F. 
Published: July 2022

Background:The effect of genetic variation in the male-specific region of the Y chromosome (MSY) on coronary artery disease and cardiovascular risk factors has been disputed. In this study, we systematically assessed the association of MSY genetic variation on these traits using a kin-cohort analysis of family disease history in the largest sample to date.Methods:We tested 90 MSY haplogroups against coronary artery disease, hypertension, blood pressure, classical lipid levels, and all-cause mortality in up to 152 186 unrelated, genomically British individuals from UK Biobank. Unlike previous studies, we did not adjust for heritable lifestyle factors (to avoid collider bias) and instead adjusted for geographic variables and socioeconomic deprivation, given the link between MSY haplogroups and geography. For family history traits, subject MSY haplogroups were tested against father and mother disease as validation and negative control, respectively.Results:Our models find little evidence for an effect of any MSY haplogroup on cardiovascular risk in participants. Parental models confirm these findings.Conclusions:Kin-cohort analysis of the Y chromosome uniquely allows for discoveries in subjects to be validated using family history data. Despite our large sample size, improved models, and parental validation, there is little evidence to suggest cardiovascular risk in UK Biobank is influenced by genetic variation in MSY.