bluuebunny/crossref_metadata_2025_split huggingface dataset:
Una propuesta metodológica innova el abordaje crítico del patrimonio cultural inmaterial en América Latina
Authors: Villamagua Ramiro 
Published: June 2022

Este trabajo enuncia la propuesta de un instrumento de análisis para la gestión integral del patrimonio cultural desde los elementos culturales del patrimonio cultural inmaterial (PCI) en territorios como los de América Latina, donde los procesos de occidentalización son el gran azote que atenta contra la diversidad cultural amerindia. Así, el Potencial Inmaterial Específico (PIE) surge a partir de un procedimiento cualitativo de análisis del devenir histórico-identitario y territorial de la localidad o zona, del análisis de los polos y de las capas culturales que yacen y subyacen en la localidad o zona estudiada (hegemonía-resistencia), y mediante la agrupación de los elementos culturales PCI en segmentos que permitan visualizar las distintas aristas con el que estas manifestaciones culturales están vinculadas en la gestión general del desarrollo desde la competencia de los Gobiernos Autónomos Descentralizados (GAD), para zanjar de una vez y por todas el vetusto abordaje sectorial que se sigue aplicando por inercia en la administración pública de nuestro país “modernizado”.
El PIE es un planteamiento crítico que cuestiona la idea de “diversidad” por tratarse de un término eurocentrista de la “otredad”, que se escuda ahora en “lo diverso”. Los términos de especificidad u originalidad acuden, en cambio, a la autonomía de la trayectoria cultural, y también a la resignificación interna (comunitaria o social) de los elementos culturales hegemónicos. Esta lectura analítica del territorio y su componente antrópico apunta a ponderar la ancestralidad y resistencia de las culturas amenazadas por la occidentalización, en aras de priorizar la gestión integral de su salvaguardia.
El PIE es un planteamiento crítico que cuestiona la idea de “diversidad” por tratarse de un término eurocentrista de la “otredad”, que se escuda ahora en “lo diverso”. Los términos de especificidad u originalidad acuden, en cambio, a la autonomía de la trayectoria cultural, y también, a la resignificación interna (comunitaria o social) de los elementos culturales hegemónicos. Esta lectura analítica del territorio y su componente antrópico apunta a ponderar la ancestralidad y resistencia de las culturas amenazadas por la occidentalización, en aras de priorizar la gestión integral de su salvaguardia.
El PIE es un planteamiento crítico que cuestiona la idea de “Diversidad” por tratarse de un término eurocentrista de la “otredad”, que se escuda ahora en “lo diverso”. Los términos de especificidad u originalidad acuden, en cambio, a la autonomía de la trayectoria cultural, y también, a la resignificación interna (comunitaria o social) de los elementos culturales hegemónicos. Esta lectura analítica del territorio y su componente antrópico apunta a ponderar la ancestralidad y resistencia de las culturas amenazadas por la occidentalización, en aras de priorizar la gestión integral de su salvaguardia.
EFEKTIVITAS MEDIA LAGU “RUANG RINDU” KARYA LETTO DALAM PEMBELAJARAN MENULIS PUISI DI MADRASAH ALIYAH NEGERI 2 PALEMBANG
Authors: Hidajati Enny , Ariska Iis 
Published: June 2022

This study aims to a difference in the ability to write poetry in the tenth
grade students of Madrasah Aliyah Negeri (MAN) 2 Palembang who participated in learning by using song media and without using song media. This study also aims to examine the effectiveness of song media in improving the ability to write poetry for students of class X in (MAN) 2 Palembang. The method used in this study is a quantitative experimental method. There are two variables in this research, namely the independent variable in the form of song media, and the dependent variable in the form of the abilityto writing poetry. Data analysis techniques were carried out using t-test and score gain. The results of the t-test on the posttest core between the control class and the experimental class resulted. . These results indicate that the song media proved effective in learning to write poetry.
Epigenetic DNA Methylation Signatures Associated With the Severity of Paget’s Disease of Bone
Authors: Diboun Ilhame , Wani Sachin , Ralston Stuart H. , Albagha Omar M. E. 
Published: June 2022

Background: Paget’s disease of bone (PDB) is characterized by focal areas of dysregulated bone turnover resulting in increased bone loss and abnormal bone formation with variable severity. PDB has a complex etiology and both genetics and environmental factors have been implicated. A recent study has identified many differentially methylated loci in PDB compared to healthy subjects. However, associations between DNA methylation profiles and disease severity of PDB have not been investigated.Objectives: To investigate the association between DNA methylation signals and PDB severity.Methods: Using 232 well-characterized PDB subjects from the PRISM trial, a disease severity score was devised based on the clinical features of PDB. DNA methylation profiling was performed using Illumina Infinium HumanMethylation 450K array.Results: We identified 100 CpG methylation sites significantly associated with PDB severity at FDR &lt;0.05. Additionally, methylation profiles in 11 regions showed Bonferroni-significant association with disease severity including six islands (located in VCL, TBX5, CASZ1, ULBP2, NUDT15 and SQSTM1), two gene bodies (CXCR6 and DENND1A), and 3 promoter regions (RPL27, LINC00301 and VPS29). Moreover, FDR-significant effects from region analysis implicated genes with genetic variants previously associated with PDB severity, including RIN3 and CSF1. A multivariate predictor model featuring the top severity-associated CpG sites revealed a significant correlation (R = 0.71, p = 6.9 × 10−16) between observed and predicted PDB severity scores. On dichotomizing the severity scores into low and high severity, the model featured an area under curve (AUC) of 0.80, a sensitivity of 0.74 and a specificity of 0.68.Conclusion: We identified several CpG methylation markers that are associated with PDB severity in this pioneering study while also highlighting the novel molecular pathways associated with disease progression. Further work is warranted to affirm the suitability of our model to predict the severity of PDB in newly diagnosed patients or patients with family history of PDB.
Low-Voltage Area at the Anterior Wall of the Left Atrium Is Associated With Thromboembolism in Atrial Fibrillation Patients With a Low CHA2DS2-VA Score
Authors: Ding Xiangwei , Li Mingfang , Chen Hongwu , Yang Gang , Zhang Fengxiang , Ju Weizhu , Gu Kai , Li Jianqing , Chen Minglong 
Published: June 2022

BackgroundNon-valvular atrial fibrillation (NVAF) in patients at low risk of thromboembolism (TE) does not mean “no risk.” We sought to assess the risk factors associated with TE in clinically low-risk AF patients with a non-gender CHA2DS2-VASc score (CHA2DS2-VA score) of 0 or 1.MethodsIn this single-center cross-sectional study, NVAF patients with a CHA2D-VA score of 0 or 1 who underwent index high-density bipolar voltage mapping of the left atrium (LA) and AF ablation were consecutively enrolled from 2017 to 2020. The population was divided into patients with and without TE history before voltage mapping. AF patients with CHA2DS2-VA score of 0 to 1 before TE (TE group) were analyzed and compared with clinically low-risk AF patients without TE history (non-TE group). The association among LA low voltage area (LVA), other clinical factors and TE history was analyzed with logistic regression.ResultsIn the TE group, LVA was more prevalent [15/25 (60%) vs. 105/359 (29.2%), p = 0.003] and more preferentially located at the anterior wall [8/15 (53%) vs. 24/105 (23%), p = 0.025]. Among patients with LVA, the activation time from the sinus node to the left atrial appendage was significantly longer in the TE group (77.09 ± 21.09 vs. 57.59 ± 15.19 ms, p &lt; 0.001). Multivariate analysis demonstrated that LVA at the anterior wall of the LA [OR: 4.17 (95% CI: 1.51 to 11.51); p = 0.006] and being female [OR: 3.40 (95% CI: 1.36 to 8.51); p = 0.009] were associated with TE history.ConclusionsLVA at the anterior wall of the LA is associated with TE history in NVAF patients with a low CHA2DS2-VA score.
Trends in Ezetimibe Prescriptions as Monotherapy or Fixed-Dose Combination in Germany 2012–2021
Authors: Katzmann Julius L. , Kieble Marita , Enners Salka , Böhm Michael , Mahfoud Felix , Laufs Ulrich , Schulz Martin 
Published: June 2022

AimsAddition of ezetimibe to statin therapy is recommended by current guidelines when low-density lipoprotein cholesterol (LDL-C) targets are not achieved with statin monotherapy. Fixed-dose combinations (FDC) improve medication adherence and facilitate risk factor control. We assessed prescription trends of ezetimibe as monotherapy or FDC with statins.MethodsData from the German Institute for Drug Use Evaluation (DAPI) containing dispensing data of &gt;80% of community pharmacies were analyzed. Prescriptions over time of lipid-lowering agents at the expense of the statutory health insurance (SHI) were extrapolated to all SHI-insured persons, representing approximately 88% of the total German population. Drug utilization was expressed as defined daily doses per 1,000 SHI-insured persons per day (DID).ResultsOf all lipid-lowering drug prescriptions in 2021, 91.2% were statin monotherapy. Ezetimibe was prescribed as monotherapy or FDC with statin in 4.4 and 2.9%, respectively. DID steadily increased for statin (69%) and ezetimibe (424%) monotherapies between 2012 and 2021. In contrast, statin-ezetimibe FDC prescriptions exhibited only a minor increase (29%). The proportion of statin-ezetimibe FDC among all statin prescriptions was stable over time at approximately 3%. FDC prescription rates by specialists were higher compared to general practitioners and varied considerably between geographic areas.ConclusionCombination lipid-lowering therapy is prescribed to a minority of patients. Prescriptions of ezetimibe as monotherapy increased to a much greater extent than statin-ezetimibe FDC. Considering the low proportion of patients achieving their LDL-C target and improved adherence to FDC compared to separate pills, statin-ezetimibe FDC may be utilized to improve the management of dyslipidemia.
Mapping of the Subglacial Topography of Folgefonna Ice Cap in Western Norway—Consequences for Ice Retreat Patterns and Hydrological Changes
Authors: Ekblom Johansson Fanny , Bakke Jostein , Støren Eivind Nagel , Gillespie Mette Kusk , Laumann Tron 
Published: June 2022

Folgefonna consists of three ice caps which are rapidly retreating in response to warmer temperatures. The melting of Folgefonna has implications for meltwater drainage and hydropower production, as well as the potential for geohazards and impacts to tourism, the communities and infrastructures surrounding the glacier. To support future adaptation strategies, we need to know the subglacial topography of the ice caps to identify water divides and possible areas for geohazards. Therefore, we mapped the subglacial topography at Sørfonna, the largest of the Folgefonna ice caps, using an ice-penetrating radar (2.5 MHz antennas; 1,000 × 500 m grid). The results show a highly irregular subglacial landscape, with deep valleys and high mountain peaks. The maximum ice thickness is 570 m and the mean ice thickness is 190 m. We examined the retreat pattern of Sørfonna using the subglacial topography map in combination with a simple ice flow model and simulated the ice retreat 150 years into the future. We used two climate scenarios (one with a 1.5°C warming and a 3% increase in precipitation, and a second with a 3.5°C warming together with 15% increase in precipitation) and focused on how the glacial retreat will cause hydrological changes in the catchments surrounding the glacier. The main drainage pattern shifts during glacial retreat, with a larger proportion of southward drainage compared to the present day. The ice flow modelling also reveals that the southern part of Sørfonna is more durable during climate change whereas the thinner part of the ice cap, in the north, melts faster. We suggest that increased winter precipitation in a future warmer climate makes the southern part of Sørfonna more resilient than many other glaciers in southern Norway. The subglacial topography map and the retreat pattern also reveal areas that may accumulate water and could potentially generate a future glacial outburst flood. Sediments from distal glacier-fed lakes around Sørfonna have been used to constrain the thresholds identified on the subglacial topography map. Combining sedimentological evidence from distal glacier-fed lakes with the new subglacial topography map confirms that the retreat of specific outlet glaciers, such as Bondhusbreen, Buerbreen, and Møsevassbreen, will have a large impact on meltwater routing, as they are situated behind bedrock thresholds in the upper part of the glacier’s catchment area.
Overriding Lithospheric Strength Affects Continental Collisional Mode Selection and Subduction Transference: Implications for the Greater India–Asia Convergent System
Authors: Li Qian , Li Zhong-Hai , Zhong Xinyi 
Published: June 2022

The India–Asia collision, starting from 55 ± 5 Ma, leads to the formation of the Himalayas and Tibetan Plateau with great gravity potential energy and large forces acting on the surrounding blocks. However, the subduction transference/jump does not occur in the southern Indian continental margin or the northern Indian oceanic plate as supposed to happen repeatedly during the preceding Tethys evolution. Instead, the continental collision and orogeny continues until present day. The total amount of convergence during the India–Asia collision has been estimated to be ∼2,900–4,000 km and needs to be accommodated by shortening/extrusion of the Tibetan plate and/or subduction of the Greater Indian plate, which is a challenging issue. In order to study the collision mode selection, deformation partition, and continental mass conservation, we integrate the reconstruction-based convergence rate of the India–Asia collision into a large-scale thermomechanical numerical model and systematically investigate the effects of overriding Tibetan lithospheric strength and the amount of convergence. The model results indicate that the absence of subduction transference during the India–Asia collision may be attributed to strain localization and shortening of the rheologically weak Tibetan plate. In case of the India–Asia collision for ∼50 Myr with a total convergence of ∼2,900 km, the model with the intermediately weak Tibetan plate could reconcile the general deformation partition and continental mass balance of the Himalayan–Tibetan system. However, the longer period of India–Asia collision for ∼55 Myr leads to significant shortening of the overriding plate that is not consistent with the Tibetan observations, in which case an oceanic basin may be required for the Greater Indian continent.
Management of Hypothyroidism in Internal Medicine: Patient Profile and Effects of an Educational Programme in the Cluster-Randomized FADOI TIAMO Study
Authors: Brancato D. , Biondi B. , Attardo T. M. , Fierro A. , Nizzoli M. , Vettor R. , Monaco E. , Romano R. , Ariete V. , Usai C. , Zagarrì E. , Campanini M. 
Published: June 2022

Background and aimsThere is still limited knowledge regarding the clinical profile and appropriateness of treatment in patients with hypothyroidism hospitalized in Internal Medicine (IM) Departments in Italy. The aim of this study is to evaluate: 1) the characteristics of patients and possible deviations from national and international clinical practice recommendations (CPRs) in evidence-based guidelines (EBGs); 2) the improvement of patient management by means of a standardized educational programme (EP).MethodsA nationwide multicentre study, comprising two replications of a retrospective survey (phases 1 and 3) with an intervening EP (phase 2) in half of the centres and no EP in the other half, was conducted. The EP was based on outreach visits. Centres were assigned to the two arms of the study, labelled the training group (TG) and control group (CG) respectively, by cluster randomization. Four EBGs and 39 CPRs provided the basis on which 22 treatment management indicators were identified (7 referring to the time of hospital admission, 15 to post-admission).ResultsThe 21 participating centres recruited 587 hospitalized patients with hypothyroidism, 421 of which were females (71.7%, mean age 74.1 + 14.4 yrs): 318 in phase 1 and 269 in phase 3. The cause of hypothyroidism was unknown in 282 patients (48%). Evaluation at the time of admission identified satisfactory adherence to CPRs (&gt;50%) for 63.6% of the indicators. In the phase 3, TG centres showed significant improvement vs CG in 4 of the 15 post-admission indicators, while 1 out of 15 was significantly worse.ConclusionsThe EP based on outreach visits significantly improved some indicators in the management of patients with hypothyroidism, with specific reference to appropriateness of TSH dosage and levothyroxine (LT4) treatment modality.Clinical Trial RegistrationClinicalTrials.gov, identifier NCT05314790.
Vitamin D Effects on Selected Anti-Inflammatory and Pro-Inflammatory Markers of Obesity-Related Chronic Inflammation
Authors: Krajewska Maria , Witkowska-Sędek Ewelina , Rumińska Małgorzata , Stelmaszczyk-Emmel Anna , Sobol Maria , Majcher Anna , Pyrżak Beata 
Published: June 2022

BackgroundObesity is related to changes in adipokine secretion, activity of adipose tissue macrophages, helper T cells, and regulatory T cells. It has been confirmed that vitamin D has potent anti-inflammatory properties. It contributes to reduction in pro-inflammatory mediators and an increase in anti-inflammatory cytokines. There is also evidence that vitamin D could decrease C-reactive protein (CRP) and affect selected haematological indices.Aim of the StudyWe aimed to evaluate the effect of vitamin D on interleukin (IL)-10, IL-17, CRP, blood leukocyte profile, and platelet (PLT) count in overweight and obese children before and after six months of vitamin D supplementation.Material and MethodsThe study group consisted of 67 overweight and obese children aged 9.08-17.5 years. The control group included 31 normal weight peers age- and sex-matched. None of the studied children had received vitamin D supplementation before the study. Data were analyzed at baseline and after vitamin D supplementation.ResultsThe study group had lower baseline 25(OH)D (p&lt;0.001) and higher white blood cell (WBC) (p=0.014), granulocyte (p=0.015), monocyte (p=0.009) and CRP (p=0.002) compared to the control group. In the study group, vitamin D levels were related negatively to nutritional status. Leukocyte profile parameters, PLT, CRP, IL-10 or IL-17 were not related to baseline 25(OH)D. Baseline IL-17 levels correlated with monocytes (R= 0.36, p=0.003) independently on 25(OH)D deficit. In children with vitamin D &lt;15ng/ml, the baseline 25(OH)D was related to CRP (R=-0.42, p=0.017). After six months of vitamin D supplementation, we noticed a decrease in CRP levels (p=0.0003). Serum 25(OH)D correlated with IL-10 in that period (R=0.27, p=0.028). Moreover, we noticed that IL-10 correlated with monocyte (R=-0.28, p=0.023). We did not find any significant associations between 25(OH)D and leukocyte profile parameters, PLT, or IL-17. The multivariable stepwise regression analysis identified IL-10 as the parameter positively associated with 25(OH)D.ConclusionsOur study confirmed beneficial effects of vitamin D supplementation in overweight and obese paediatric populations. Vitamin D intake seems to exert its anti-inflammatory effect mainly via decreasing the CRP level and protecting stabile values of IL-10, rather than its impact on pro-inflammatory factors such as lL-17 and leukocyte profile parameters.
Factors Related to Metabolic Syndrome Development and Recovery in Chinese Adults: A Prospective Longitudinal Study
Authors: Zhang Chenyu , Fang Sisi , Wang Haoyu , Shan Zhongyan , Lai Yaxin 
Published: June 2022

ObjectiveThis study was a prospective assessment of the epidemiological characteristics of metabolic syndrome (MetS) in cities in Northeast China. We explored the factors that affect the occurrence and outcome of MetS according to sex.Design and MethodsThis was a longitudinal survey assessing MetS status among 750 urban community residents in China. At baseline, the intra-abdominal fat area was measured by MRI, simple anthropometric parameters (body mass index (BMI), waist circumference (WC), etc.) were used to evaluate fat distribution; blood pressure and blood lipid profile were measured; an oral glucose tolerance test (OGTT) was used to detect blood glucose; questionnaires were used to investigate lifestyles. Follow-up was conducted after 1.5 years (follow-up rate was 66.93%) to analyze the incidence of MetS and the influencing factors of MetS outcomes according to sex.ResultsThe 1.5-year cumulative incidence of MetS in the survey area was 25.40%. Men with visceral obesity were more likely to develop MetS than those with subcutaneous obesity (OR=9.778, p&lt;0.05). Increased BMI (OR=1.379) and blood uric acid (BUA)&gt;416 mmol/L (OR=2.318) were associated with the occurrence of MetS in men (all p&lt;0.05). At the initial visit, BUA&gt;356.9 mmol/L (OR=3.538), increased BMI (OR=1.212), and increased HbA1c (OR=2.577) were associated with the occurrence of MetS in women (all p&lt;0.05). After 1.5 years, 25.37% of MetS patients no longer had MetS. Elevated diastolic blood pressure (DBP) (OR=1.097) and increased visceral fat (OR=1.023) at the initial visit made men with MetS less likely to recover from MetS (all p&lt;0.05). Higher High-density lipoprotein cholesterol (HDL-C) at the initial visit made women with MetS more likely to recover from MetS (β: -3.509, OR=0.003, p&lt;0.05).ConclusionThere are different risk factors for MetS in different genders. Hyperuricemia is a risk factor for the onset of MetS in both men and women.
Cu/Fe Bimetallic Treatment Performance on Organophosphorus Pesticides
Authors: Wu Xianpei , Wang Yanqiong , Xu Jing , Wang Hongwu 
Published: June 2022

Typical organophosphorus pesticides, such as glyphosate, trichlorfon, and ethephon, are widely used nowadays, and the treatment of their production wastewater is difficult to achieve by conventional water treatment methods. A Cu/Fe bimetallic system has been proposed as a viable technology to treat toxic and refractory pollutants. The performance of the system with different pH, Cu/Fe molar ratios, Cu/Fe dosages, and initial glyphosate concentrations was analyzed to investigate the operational factors affecting glyphosate removal by the Cu/Fe bimetallic system. Acidic pH (2.0), 250 g/L Cu/Fe dosage, 0.25% Cu/Fe, and 60 mg/L initial glyphosate concentration were the appropriate conditions for glyphosate removal, in which the efficiency of the system was in accordance with the pseudo–second-order kinetic model. Under this condition, the removal efficiencies of total phosphorus and total organic carbon reached 99 and 65%, respectively. The Fe/Cu bimetal surface was characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, and Fourier transform infrared spectroscopy. The optimal conditions for glyphosate decomposition were applied to the treatment of trichlorfon and ethephon. The removal efficiency of the system was poor, but its toxicity to luminescent bacteria Q67 was remarkably reduced.