bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep compressed sensing-based accurate blade vibration reconstruction using sub-sampled tip-timing measurements
Authors: Chen Zhongsheng , Sheng Hao , Liu Chengwu , Xiong Yeping 
Published: March 2022

Abstract
Blade tip-timing (BTT) measurement is seriously sub-sampled due to the restricted number of BTT probes, so that true blade vibration characteristics can hardly be directly extracted. Blade vibration responses are always multi-band which can be considered to be sparse, so compressed sensing (CS) can be used to reconstruct blade vibrations. However, there is often less prior sparse information of multi-band blade vibrations, so that classical reconstruction algorithms are less effective. In order to deal with it, this paper presents an end-to-end deep compressed sensing (DCS)-based blade vibration reconstruction method which is composed of four key operations. First, angular-domain sampling is introduced to adapt complex operation conditions and a Multi-coset BTT measurement model is proposed in angular domain. Then a DCS model of BTT measurements is presented in order domain and a convolutional neural network (CNN) is specially designed. Next, a Simulink model is presented to simulate BTT sampling process under variable speeds and simulations are done to study the effects of the CNN architecture on the reconstruction accuracy. The results demonstrate that convolution layers with ReLU after BN are much beneficial for BTT vibration reconstruction and the proposed method is better than classical algorithms in terms of reconstruction accuracy and speed. In the end, experiments are carried out to validate the DCS-based reconstruction method and true vibration Engine Order can be recovered effectively without prior information. Thus the proposed method may set up a novel direction for BTT signal analysis and blade vibration monitoring.
A Genetic Programming-based Approach for Classifying Pancreatic Adenocarcinoma: the SICED Experience
Authors: D'Angelo Gianni , Scoppettuolo Maria Nunzia , Cammarota Anna Lisa , Rosati Alessandra , Palmieri Francesco 
Published: March 2022

Abstract
Ductal adenocarcinoma of the pancreas is a cancer with a high mortality rate. Among the main reasons for this baleful prognosis is that, in most patients, this neoplasm is diagnosed at a too advanced stage. Clinical oncology research is now particularly focused on decoding the cancer molecular onset by understanding the complex biological architecture of tumor cell proliferation. In this direction, Machine-Learning has proved to be a valid solution in many sectors of the biomedical field, thanks to its ability to mine useful knowledge by biological and genetic data. Since the major risk factor is represented by genetic predisposition, the aim of this study is to find a mathematical model describing the complex relationship existing between genetic mutations of the involved genes and the onset of the disease. To this end, an approach based on evolutionary algorithms (Evolutionary Algorithm) is proposed. In particular, Genetic Programming is used, which allows solving a Symbolic Regression problem through the use of Genetic Algorithms. The identification of these correlations is a typical objective of the diagnostic approach, and is one of the most critical and complex activities in the presence of large amounts of data that are difficult to correlate through traditional statistical techniques. The formula obtained highlights the importance of the complex relationship existing between the different gene's mutations present in the tumor tissue of the group of patients considered.
Evaluation of the Effects of Duloxetine Treatment on Anterior Segment Parameters by Optical Coherence Tomography
Authors: Özer Murat Atabey , Sarı İlker Fatih , koç hakan , yavuz nurçe çilesizoğlu , özen serkan , kulaklı fazıl 
Published: March 2022

Abstract
Purpose: To evaluate the effects of Duloxetine on anterior segment parameters and intraocular pressure(IOP) in open angle eyes.Methods: 38 eyes of 38 patients with fibromyalgia who had open or wide open angles according to the Shaffer classification. Anterior segment optic coherence tomography was performed before and after (month 3) Duloxetine treatment. IOP, central corneal thickness(CCT), corneal endothelial cell density(CECD) and anterior chamber depth(ACD) were also recorded and evaluated. Results: No statistically significant difference was determined in IOP, CCT and CECD(p > 0.05). However, a statistically significant increase was determined in both the temporal and nasal anterior chamber angle, angle opening distance, nasal trabecular-iris space area and ACD values between the baseline and month 3 (p < 0.001). Conclusion: We think that the short term use of Duloxetine does not lead to clinically significant changes despite their statistically significant effects on the anterior chamber parameters.
Performance Analysis of Downlink Multipath Multi-User NOMA-VLC System
Authors: Kumar Ajit , Ghorai Swapan Kumar , Sharan Nishant 
Published: March 2022

Abstract
In the present paper, the performance of non-orthogonal multiple access (NOMA) in a downlink multipath multi-user Visible Light Communication (VLC) system has been evaluated w.r.t bit-error rate (BER), sum rate & outage probability. The results show that the sum rate and BER performance improve with the increase in semi-angle of the LED using both Line-of-sight (LOS) and LOS plus first reflection (L-R1) signals. The simulation results display that there is optimal value of at which minimum BER is achieved. However, the optimal angle of semi-angle varies with the number of users and order of reflection of signal. In case of two-user system with LOS signal, the optimal angle is and for user-1 & user-2 respectively, whereas, for three-user system the optimal angle is for user-1 and it is for each user-2 and user-3. The BER simulation results for L-R1 signal reveal that the successive interference cancellation (SIC) efficiently decodes the signal for two-user system with optimum performance at equals to but as the number of users increases to three, it fails to decode the signal. The results of sum rate vs. offset using LOS signal show that sum rate for two-user system monotonically increases & then decreases with the increase in semi-angle. The optimal angle is for the maximum sum rate which also supports the BER results. The effect of shadowing (blocked LOS signal) shows that the sum rate is zero for lower values of semi-angle of LED. Finally, the outage probability against target rate of far user confirms the key finding results of shadowing.
Naturally aligned cell delivery platform to augment post-infarction neovasculature and ventricular remodeling
Authors: Shin Hye , Thakore Akshara , Tada Yuko , Pedroza Albert , Ikeda Gentaro , Chen Ian , Chan Doreen , Jaatinen Kevin , Kawamura Masashi , Yang Phillip , Wu Joseph , Appel Eric , Fischbein Michael , Woo Y Joseph , Shudo Yasuhiro 
Published: March 2022

Abstract
We demonstrated that joint delivery of human-derived endothelial progenitor cell (EPC) and smooth muscle cell (SMC) sheets mimics the native architecture of structurally mature blood vessels and contributes to limiting ventricular remodeling using a confluent SMC-EPC bi-level cell sheet engineered by cell-sheet technology and transplanted into an athymic rodent model of myocardial infarction. Enhanced vasculogenic potential was observed in vitro when EPCs were stimulated with SMC-conditioned culture medium, augmenting angiogenesis in vivo. Increased structurally mature vessel density, myocardial upregulation of biological adhesion, and vasculature developmental genes in the ischemic border zone myocardium showed interaction between cells and the extracellular matrix. Cell fate tracking experiments featuring xenogeneic transplantation showed transplanted EPCs and SMCs to have elements of the newly formed vasculature. Specialized magnetic resonance imaging of the cell-sheet-transplanted rodents suggested prolonged cell retention. The robust angiogenic effect of the transplanted cell sheets induced reverse ventricular remodeling of the ischemic heart. Bioinformatic analyses indicated that these cell sheets promote transcriptome-wide changes in the left ventricular response to acute ischemia, promote productive remodeling, and prevent pathological ventricular dilation. Thus, the human-derived, spatially arranged SMC-EPC bi-level cell sheet is a promising therapy for increasing myocardial viability and limiting adverse ventricular remodeling after myocardial infarction.
Impact Of Early Supportive Care Assessment On Treatment Decision In Head And Neck Cancer Before Concomitant Chemoradiotherapy
Authors: Cherifi François , Villemin Maud , Bisiaux Frederique , Johnson Alison , Laviec Heidi Solem , Rambeau Audrey 
Published: March 2022

Abstract
Objective: To assess the impact on oncological treatment and supportive care interventions in patients treated with chemoradiation (CRT) for advanced head and neck cancer (HNC) of a global pretherapeutic comprehensive supportive care assessment performed in an outpatient supportive care clinic (OSCC). Methods: In this monocentric prospective observational study, we included all patients considered for CRT (exclusive or post-operative) for advanced HNC from February 2019 to March 2020. The following frailty indicators were assessed: comorbidities (Charlson Index), nutritional status, altered functional ability (ADL and IADL), social precarity (EPICES score), cognitive impairment (MoCA score), addictive habits and pain.Results: OSCC led to a change in treatment for 13.7% of patients, mainly de-escalations. Ninety-three percent of patients had at least one altered domain, including 50% with three or more altered domains. Cognitive function was the most frequently altered domain (66.7%). Altered functional ability was significantly associated with treatment de-escalation after OSCC. Treatment interruptions were significantly associated with treatment de-escalation and social precarity. De-escalation was also associated with a significantly poorer PFS (median of 23.2 mos. vs 8.8 mos., HR=2.18 95%IC[1.02- 4.63] p=0.037)) and a non-significant trend towards worse OS (median 23.3mos. vs not reached (HR = 2.16 95%CI[0.88-5.31] p=0.0836).Conclusion: We strongly encourage the creation of OSCC for patients treated with chemoradiation for HNC. This practice, through an exhaustive assessment, favors therapeutic adaptation, personalized follow-up and optimization of supportive care.
Relationships Among Attitude Toward Leisure, Satisfaction With Leisure Policies, Satisfaction With Leisure Activities, And Happiness In Korean Caregivers For Young Children
Authors: Yoo Jieun 
Published: March 2022

Abstract
This study investigated the effect of attitude toward leisure and satisfaction with leisure policy on satisfaction with leisure activities and level of happiness in Korean caregivers for young children. Data were collected from 864 participants (397 men and 467 women) using the 2018 National Leisure Activity Survey (NLAS). The results showed that there were no significant differences between male and female caregivers in terms of satisfaction with leisure policy, satisfaction with leisure activities, and level of happiness. Women had more positive attitudes toward leisure. Satisfaction with leisure activities mediated the relationship between attitude toward leisure, satisfaction with leisure policy, and level of happiness; there were no significant differences between men and women with regard to the variables. The study suggests that attitude toward leisure and satisfaction with leisure policy promote the happiness of Korean caregivers for young children.
Phenotypic Divergences in Growth and Reproduction Underpin The Invasion of Suckermouth-Amored Catfishes to Lotic and Limnic Habitats in Vietnam
Authors: Duc Dien Tran , Ha Vo Thi , Dang Mai , Sang Huynh Minh , Dinh Khuong V. , Hieu Nguyen Trinh Duc , I.A Stolbunov 
Published: March 2022

Abstract
Suckermouth-amored catfishes (Pterygoplichthys spp.) is one of the most widespread invasive species in Vietnam. However, it is relatively unknown how these species have evolved in divergent adaptations to local conditions varying in habitat types, which is essential for managing their invasion in Vietnam. We addressed this by analyzing a large number of fish (766 phenotypes) collected in lotic (Dinh River) and limnic (Suoi Trau Resevoir) habitats in southern Vietnam during one year. Allometric growth patterns estimated by von Bertalanffy growth functions were \({L}_{t}= 500\left(1-{e}^{-0.71(t-0.44)}\right)\) in Dinh River and \({L}_{t}= 346\left(1-{e}^{-1.01(t-0.62)}\right)\) in Suoi Trau Resevoir. Estimated fish age was 2.9 to 4.2 years old. The percentage of fish with matured ovaries peaked in August (100%) and was lowest in February (< 10%), indicating that these fish breed all year round. The main reproductive season is April-October, with a peak in July-August as indicated by gonado-somatic indices index and monthly changes in the percentage of matured fish. The length at 50% maturity 22.93 and 17.51 cm for females from lotic and limnic habitats, respectively. Lotic fish had the fecundity (5830 ± 546 oocytes/ind.) which was five times larger than that of limnic fish (1042 ± 107 oocytes/ind.). This result was consistent with the larger oocytes of females: 2.94 ± 0.03 and 2.58 ± 0.01 mm for fish from Dinh River and Suoi Trau Resevoir, respectively. The faster growth and bigger fish with higher fecundity in the lotic habitats suggest they can accelerate greater population growth, potentially affecting local communities more than those from limnic habitats. Our study sheds light on substantial phenotypic divergences in reproduction and growth of the armored catfish between lotic and limnetic habitats in Vietnam, which is fundament for arriving at an effective management plan.
Comparison of bedside ultrasonography and bedside chest radiography in neonatal peripherally inserted central catheters：a before and after self-control study
Authors: Wu Liping , Liu Xuexiu , Tao Xiaojun , Xu Ye , Zhang Xianhong , Chen Yanhan 
Published: March 2022

Abstract
The study is a prospective before and after self-control clinical trial.To compare the applications of bedside ultrasonography (US) and bedside chest radiography (CR) in positioning peripherally inserted central venous catheter (PICC) at Neonatal Intensive Care Units (NICUs). A consecutive series of 181 neonate patients were finally enrolled for PICC placement. CR, followed by US, was used to evaluate and readjust the sites of catheter tips. The imaging capability for PICC key structures, fluctuation of the measured data, measurement of tip-to-atrium distance, operation time, infants’ body temperature changes and direct expenses of the two imaging modalities were obtained and compared.The following results are obtained:1.Comparison in viewing PICC key structures: the display rate of catheter tip, SVC-and-right-atrium junction, IVC-and-right-atrium junction and tip-to-atrium distance is 99.47%, 100%, 100% and 99.47% for US and 100%, 98.42%, 97.37% and 95.79% for CR, respectively. 2. Fluctuation of the measured data by US and CR: the tip-to-atrium distance measured by US is 0.631 (0.435-0.820) cm; and that measured by CR is 0.593 (0.210-0.825) cm. US showed narrower range of datum variance. 3. Consistency and correlation between US and CR: for consistency analysis, Kappa coefficient (κ) was 0.843 (P < 0.05), showing their favorable consistency; for correlation analysis, Pearson correlation coefficient (r) was 0.739 (P < 0.05), suggesting a close correlation. 4. Comparison of operation time and infants’ body temperature drop: for a CR exam, the time period taken was significantly longer than that of US（59.7±26.33min vs79.6±28.06min, P < 0.001); and CR operations caused a significant babies’ body temperature drop compared to US (0.14 ± 0.11℃ vs 0.34 ± 0.19℃, P < 0.001). 5. Comparison of the direct expenses: the total cost for CR positioning was significantly higher than that for US (¥153.99 yuan vs. ¥143 yuan, P = 0.026).It can be inferred that US positioning of PICC tip exhibited superior traits to CR. We suggest that US can be used routinely for the neonates’ PICC placement at NICU.
Mapping the contours of an emerging phase out science
Authors: Trencher Gregory , Rinscheid Adrian , Rosenbloom Daniel , Koppenborg Florentine , Truong Nhi , Temocin Pinar 
Published: March 2022

Abstract
Phase-out has emerged as a policy approach to confront multiple sustainability crises. From ozone-depleting substances and hazardous chemicals to fossil fuels and transport technologies, phase-out experiences have been documented by diverse scientific communities. To consolidate this dispersed knowledge and inspire more systematic research, we map the evolution of scientific discussions about phase-out through a systematic literature review. Examining 870 papers published since 1970, we trace the evolving nature of phase-out strategies in terms of targets, geographic and industrial contexts, policy instruments and drivers. This provides a multi-faceted overview of an emerging and rapidly growing ‘phase-out science’ rooted across the full spectrum of scientific enquiry. Evolution of this science is marked by broadening engagement with a growing diversity of targets, contexts, and policies. Our analysis also shows how phase-out policies have recently gained momentum as a tool to tackle climate change, with a particular focus on fossil fuels and associated technologies.
Analysis of the Diversity of Yeast Communities in Xinjiang Honey
Authors: Wei Yumei , Lei Yonghui , Liu Ailing , Zhu Shanshan , Li Yang , Cai Yanli , Sun Yanfei 
Published: March 2022

Abstract
Honey is widely produced in China as a natural health food with high nutritional value. In this study, high-throughput sequencing (HTS) and culture-dependent methods were used to assess the yeast diversity of wild honey from three different regions of Xinjiang. The analysis of HTS data of 26S rDNA NL1F and NL2R region genes revealed the highest number of operational taxonomic units (OTUs) of the yeast genus Zygosaccharomyces in honey, followed by the genera Aureobasidium and Clavispora. Multifloral honey is not only different in yeast structure and composition from monofloral honey, but also more diverse than monofloral honey. Thirty-five yeast strains were obtained by traditional isolation and culture methods, and morphological, physiological and biochemical, and 26S rDNA D1/D2 domain genes were sequenced to identify 11 yeast species, including Zygosaccharomyces siamensis, Aureobasidium pullulans, Naganishia albida, Saccharomyces cerevisiae, Wickerhamomyces anomalus, Rhodotorula glutinis, Pichia kluyveri, Barnettozyma californica, Rhodotorula kratochvilovae, Candia tropicalis, Pichia terricola, and these results are not entirely consistent with those obtained using high-throughput sequencing methods. Different species of honey may have contributed to the diversity of yeast. The results of this study provide basic information on the yeast diversity of native honey in Xinjiang, which will help to develop germ plasm resources of yeast in honey.
lncRNA CHROMR promotes the expression of the CNNM1 gene by adsorbing hsa-miR-1299 to obtain drug resistance in diffuse large B lymphoma cells
Authors: Wei Changyuan , Wang Mingyue , Miao Zhichao 
Published: March 2022

Abstract
Background: Long-chain non-coding RNA (LncRNA) is differentially expressed in diffuse large B cell lines with varying degrees of resistance to rituximab, which plays a regulatory role in the cell cycle, and has a cancer-promoting effect. Methods: This study investigated the role of lncRNA CHROMR in the diffuse large B lymphoma cells producing rituximab resistance and explored its underlying mechanism. We searched the GEO database for lncRNA-related expression data of rituximab resistance in the diffuse large B lymphoma cell line and tested it in cell lines. It was found that CHROMR was differentially expressed in different types of samples, and then the effect of CHROMR in the acquisition of drug resistance of cells was verified through experiments such as cell cycle, cell apoptosis, and cell proliferation. We use bioinformatics analysis to predict that there may be a CHROMR/miR-1299/CNNM1 signaling pathway that enables the diffuse large B lymphoma cells to acquire drug resistance. We first use dual-luciferase analysis to verify the interaction between pathway molecules. We use bioinformatics analysis to predict that there may be a CHROMR/miR-1299/CNNM1 signaling pathway that enables the diffuse large B lymphoma cells to acquire drug resistance. We first use dual-luciferase analysis to verify the interaction between pathway molecules. The cells were co-transfected with or without sh-CHROMR and miR-1299 inhibitor, CHROMR -over and miR-1299 mimic, whose proliferation, apoptosis, and cell cycle were determined subsequently. Results: The results show that restoring the expression of miR-1299 can offset the effects of changes in CHROMR expression. Conclusions: CHROMR promotes the expression of CNNM1 by adsorbing miR-1299 to cause changes in the cell cycle of the diffuse large B lymphoma cells to produce drug resistance.
Development of composite thin-film nanofiltration membranes based on polyethersulfone for water purification
Authors: El-Zahhar Adel , Alghamdi Majed M. , Alshahrani Norah M. , Awwad Nasser S. , Idris Abubakr M. 
Published: March 2022

Abstract
Composite thin-film nanofiltration membranes were prepared by interfacial polymerization of trimesoyl chloride (TMC), polyvinyl pyrolidone (PVP) and montmorilonite (MMT) composite on the porous polyethersulfone (PES) membrane. The effect of preparation parameters were studied as; reaction time, PVP concentration and MMT content. The properties of the prepared composite thin film membranes were analyzed in terms of their chemical structure, surface morphological features, pure water contact angel, zeta potential, pure water permeation flux (PWP) and solutes rejections. The composite thin film membranes had smoother surfaces, different surface functionality and amphoteric surafce with point of zero charges within pH 7-7.5. The PWP was found to increase with increasing MMT content up to 0.10 wt. %. The rejection of crystal violet dye (CV) was studied using the prepared membranes, where the membrane with 0.5 % PVP, 0.10% MMT at reaction time 6 min showed PWP of 18.1 (L/m2.h.bar) and CV rejection of 80.01 %. The rejection of Na2SO4 and MgCl2 was found to increase with MMT content and reached 96% and 35.4 %, respectively. The steady state flux was decreased by 5% with increasing MMT content from 0.10 to 0.12 wt. % reflecting antifouling improvement with MMT.