bluuebunny/crossref_metadata_2025_split huggingface dataset:
Análise comparativa dos modos ventilatórios Ventilação Controlada a Volume (VCV), Ventilação a Pressão Controlada (PCV) e Ventilação com Pressão Regulada e Volume Controlado (PRVC) sobre mecânica ventilatória, tempo de ventilação mecânica, internação em UTI e sobrevida em pacientes neurológicos
Authors: Mourão Maryéla Neves , Liano Mariely Souto , Malheiros Rafael Tamborena , Fausto Daniela Martins de , Castro Antonio Adolfo Mattos de 
Published: October 2022

Objetivos: Comparar o desfecho dos modos ventilatórios VCV, PCV e PRVC em relação a mecânica ventilatória, o tempo de ventilação mecânica, tempo de internação em UTI e sobrevida em pacientes neurológicos. Métodos: Estudo de coorte randomizado comparando três modalidades ventilatórias VCV, PCV e PRVC em pacientes neurológicos com diagnóstico de AVC isquêmico ou hemorrágico e TCE, ventilados mecanicamente e internados em UTI. O ventilador mecânico era ajustado conforme modo sorteado e com parâmetros ventilatórios ajustados para manter volume corrente de 6 a 8 ml/Kg e parâmetros gasométricos dentro da normalidade. Foram coletados dados demográficos, parâmetros hemodinâmicos, gasométricos e ventilatórios e as escalas APACHE II, RASS e Glasgow. Ao final do protocolo foram registrados os dados de mortalidade/sobrevida, tempo de internação em UTI e alta da unidade. Resultados: O grupo PVC apresentou maior tempo de permanência em ventilação assisto controlada em relação aos grupos VCV e PRVC (p=0,04). Além disso, o grupo PCV apresentou maior tempo de ventilação mecânica (p=0,002), maior tempo de internação em UTI (p=0,01). Ainda, não houve diferença entre os grupos quanto a sobrevida, o grupo VCV e PRVC apresentou uma tendência a sobrevida quando comparado ao PCV (p=0,4). Por fim, não houve diferença entre os grupos em relação às características clínicas, mecânica ventilatória e gasométricas. Conclusão: Pacientes neurológicos devem ser ventilados mecanicamente preferencialmente em modo VCV e PRVC, pois estes modos apresentam vantagens sobre o modo PCV em pacientes neurológicos.
Produtos Naturais e o ensino de Ciências: Tubérculo Amazônico como alternativa de indicador Ácido e Base
Authors: Peres Eldrinei Gomes , Oliveira Edriely Vilena de , Gonçalves Tiago Maretti , Yamaguchi Klenicy Kazumy de Lima 
Published: October 2022

O presente artigo descreve a análise de um indicador natural de pH obtido a partir do tubérculo do cará-roxo (Dioscorea trifida), espécie muito conhecida na região Norte e nordeste do Brasil. O objetivo foi testar o potencial do extrato como indicador natural de substâncias ácidas e básicas e otimizar seu método de extração por meio de maceração utilizando diferentes solventes de extração. A amostra utilizada no presente estudo foi obtida no município de Coari, Amazonas. Diferentes parâmetros de extração foram utilizados: o material seco e in natura, macerados em temperatura ambiente, e o solvente etanol e hidroalcoólico. A capacidade indicadora dos extratos foi testada com soluções com pH de 1 a 14 e analisada pela absorbância na região UV (300 à 700 nm), por meio de espectrofotômetro. Os resultados evidenciaram uma significativa eficiência dos extratos como indicador natural, com coloração característica conforme a acidez do meio (ácido – vermelho violeta, básico – azul violeta e neutro - violeta). O extrato hidroalcoólico a partir da amostra seca e triturada apresentou melhor desempenho, com uma maior absorção no comprimento de onda característico. Conclui-se que o cará-roxo é uma alternativa para ser utilizada nas aulas de Ciências, em razão do processo de extração simples, com materiais de baixo custo, sendo uma técnica reprodutível e ambientalmente adequada, somado a um bom desempenho de mudança de coloração em soluções com diferentes valores pH. Assim, esse extrato se apresenta uma possibilidade de substituição dos indicadores tradicionais disponíveis no mercado.
REBRANDING COFFEE SHOP 12BARS UNTUK MENINGKATKAN BRAND AWARENESS MELALUI SOSIAL MEDIA INSTAGRAM
Authors: Pratama Aditya , Rahmadianto Sultan Arif , P Bintang Pramudya P 
Published: October 2022

Seiring berjalannya waktu banyak sekali industri makanan dan minuman yang dibuka oleh banyak pengusaha. Salah satu peluang usaha yang digemari adalah kafe. Banyak sekali kafe-kafe yang dibuka di Indonesia dan juga di kota Malang. Setiap kafe memiliki keunikan dan ciri khas nya masing-masing. Oleh karena itu persaingan antara masing-masing kafe sangatlah ketat. Salah satu kafe yang memiliki potensi untuk bertahan dalam persaingan ini adalah 12Bars. 12Bars adalah sebuah kafe yang menjual minuman berbahan dasar kopi dan juga non kopi. Kopi yang digunakan oleh 12Bars adalah kopi yang sangat segar, karena pemiliknya membeli biji kopi segar langsung dari petani kopi. Namun, 12Bars masih kurang dikenali oleh masyarakat kota Malang karena kurangnya identitas visual yang kuat dan promosi yang dilakukan. Oleh karena itu, dibutuhkan brand identity yang dapat menarik perhatian konsumen dan calon konsumen 12Bars. Tujuan dari perancangan ini adalah membuat brand identity baru dan buku GSM yang berguna sebagai panduan dalam mengaplikasikan logo dan elemen visual lainnya untuk menjaga konsistensi brand. Penelitian ini menggunakan metode kualitatif, untuk mendapatkan data-data yang dibutuhkan. Kemudian data tersebut akan diolah menggunakan metode analisis SWOT, dan creative brief. Selain itu juga akan dirancang media promosi sosial media berupa feeds Instagram dan packaging yang akan berguna sebagai media promosi.
Perancangan Webtoon Happy Girls bagi Remaja Usia 15 hingga 19 Tahun sebagai Edukasi Moral terhadap Kepedulian dalam Kehidupan Berkeluarga
Authors: Mintodihardjo Milka Theophilia , Sukmaraga Ayyub Anshari , Nirwana Aditya 
Published: October 2022

Perancangan Webtoon "Happy Girls" Bagi Remaja Usia 15-19 Tahun Sebagai Edukasi Moral Terhadap Kepedulian dalam Kehidupan Berkeluarga. Milka Theophilia Mintodihardjo. 331810011@student.machung.ac.id. Kemajuan teknologi menghasilkan budaya baru pada kehidupan manusia bagi seluruh kalangan. Orang tua, remaja, dan anak-anak mendapatkan dampak dari berkembangnya teknologi tanpa terkecuali. Dampak dari berkembangnya teknologi juga mempengaruhi hubungan antara orang tua dengan anaknya terutama anak remaja yang aktif menggunakan gawai pada keseharian mereka. Penulis merancang webtoon "Happy Girl" agar dapat memberikan edukasi moral terhadap kepedulian dalam kehidupan berkeluarga bagi remaja secara menarik dan lebih mudah diterima bagi remaja. Hasil dari perancangan penulis telah berhasil mendapatkan komentar positif dan memenuhi target penulis yaitu webtoon dengan 7 episode dengan minimal 150 panel. Pendukung dari webtoon yang penulis rancang adalah kaos, stiker, totebag, tas serut, gantungan kunci, dan pouch agar dapat menarik minat para remaja usia 15-19 tahun.

Kata kunci: Webtoon, Happy Girls, Orang Tua, Remaja, Kepedulian, Keluarga
Perancangan Buku Ilustrasi Lift the Flap sebagai Media Edukasi Fauna Endemik di Indonesia untuk Anak Usia 6 9 Tahun
Authors: Putri Sicilia Anita Dewi Endra , Rahmadianto Sultan Arif , P Bintang Pramudya P 
Published: October 2022

Abstrak
Indonesia dikenal negara yang kaya akan keanekaragaman hayati tertinggi di dunia selain itu juga termasuk dalam tingkat endemisme yang tinggi menurut IUCN. Untuk itu perlu adanya tingkat kesadaran tinggi untuk mengetahui dan melestarikan fauna-fauna yang tergolong langka dalam menjaga keseimbangan ekosistem Indonesia, khususnya bagi anak-anak. Maka dari itu, perlu dibuat buku ilustrasi interaktif sebagai edukasi mengenai fauna endemik di Indonesia. Tujuannya adalah untuk memberi pengetahuan kepada anak usia 6-9 tahun mengenai fauna endemik di Indonesia yang terancam punah. Buku ini dibuat interaktif dengan lift the flap agar anak-anak aktif ikut serta sehingga informasi dapat tersampaikan dengan baik. Dalam penelitian ini metode yang digunakan adalah metode kualitatif dengan pengumpulan data secara observasi dan studi pustaka. Media pendukung dalam perancangan ini adalah gantungan kunci, totebag, kaos, sticker dan tumbler.
Kata kunci: Fauna Indonesia, buku interaktif, ilustrasi, fauna endemik.
Perancangan Aset Gamified Learning Management System Game Klasster dengan Metode Myerson untuk Meningkatkan Ketertarikan Terhadap Education Game Bagi Siswa Sekolah Dasar
Authors: Brandon Brandon , Rahmadianto Sultan Arif , P Bintang Pramudya P 
Published: October 2022

Semakin bertambahnya perkembangan tekonologi khususnya dalam hal game, game sendiri telah menunjukkan eksistensinya dalam bidang edukasi dan telah banyak game yang ada pada saat ini memiliki tujuan untuk kemajuan edukasi para penggunanya. Di sisi lain, masa pandemi dari Covid-19 sendiri telah menjadi sebuah hambatan besar dalam dunia pendidikan dimana semua hal edukasi harus berakhir dengan sistem daring. Hal ini sendiri menjadi permasalahan dikarenakan para murid tidak dapat mengikuti kegiatan belajar secara maksimal dan tidak banyak juga yang menilai bahwa sistem pendidikan secara daring sangatlah tidak efektif dan membosankan. Peran dari game Klasster ialah pemaksimalan kegiatan belajar mengajar agar lebih mudah disukai oleh anak-anak dan memiliki kesan seru dan penuh interaktif walau tetap dalam sistem daring. Perancangan ini dilakukan dengan menggunakan metode perancangan yang didasarkan dengan hasil wawancara dan metode Myerson untuk didapatkannya data valid dalam perancangan. Tujuan dari perancangan ini ialah merancang aset-aset yang dapat memberi kesan visual menarik dan seru bagi para pengguna agar secara keseluruhan game Klasster ini sendiri dapat memenuhi visi misinya. Selain itu dirancang juga media promosi cetak berupa buku concept art dari perancangan aset game Klasster serta ada juga tote bag, baju, serta masker yang bertujuan sebagai media promosi untuk meningkatkan brand awareness orang-orang terhadap game Klasster.
PERANCANGAN MEDIA PROMOSI BERBASIS VIDEOGRAFI UNTUK LUGO COFFEE DI TULUNGAGUNG
Authors: Dewi Yustika , Nugroho Didit Prasetyo , Rahmadianto Sultan Arif 
Published: October 2022

Abstrak
Lugo Coffee adalah salah satu kedai kopi yang ada di Kota Tulungagung. saat ini kedai kopi sudah sangat banyak di beberapa tempat di Jawa timur sehingga semakin banyak kedai kopi yang mengalami penurunan dalam penjualannya dikarenakan kuranganya informasi yang disampaikan kepada masyarakat. Maka dari itu dibutuhkan media promosi yang dapat menarik para pemuda melenial yang gemar nongkrong. Oleh karena itu dibuatlah perancangan dengan bertujuan mendapatkan visualisasi konsep melaui media video promosi menggunakan dua teknik yaitu teknik Stop Motion dan B-Roll yang berisi informasi tentang kedai kopi tersebut bertujuan dapat meningkatkan minat masyarakat dan penghasilan dari Lugo Coffee. Metode perancangan yang digunakan adalah metode perancangan komunikasi kreatif yang dipadukan dengan metode pengumpulan data kualitatif. Video promosi ini akan menjadi dua jenis video yang berbeda namun memiiki tujuan yang sama, yang pertama adalah video promosi menggunakan Teknik Stop Motion berdurasi 1 menit 41 detik dan video promosi menggunakan Teknik B-Roll berdurasi 47 detik. Kesimpulan dari perancangan ini adalah mendapatkan visualisasi konsep video promosi untuk memberikan informasi kepada masyarakat dan menarik generasi milineal melalui media video promosi dan media pendukung lainya yaitu Glass, tote beg, paper bag,, cup, poster

Kata kunci: Video Promosi, Teknik Video, Kedai Kopi, Kota Tulungagung
How Should Complainer Anonymity for Sexual Offences be Introduced in Scotland? Learning the International Lessons of #Letherspeak
Authors: Tickell Andrew 
Published: October 2022

It is often claimed that complainers in sexual offence cases have an “automatic right to lifelong anonymity in UK law.” While this is true in England, Wales and Northern Ireland – Scots law currently imposes no automatic restrictions on the identification of people who say they have been victims of rape and other sexual offences. Underpinned by a comparative analysis of twenty common law jurisdictions – including Ireland, India, Bangladesh, Singapore, Hong Kong, Canada, New Zealand and Australia – this article considers how complainer anonymity could and should be introduced in Scotland. This article is in three main parts. The first considers the reasons for granting anonymity to complainers in sexual cases. The second explores how complainer anonymity is realised in the laws of the twenty comparator jurisdictions considered in this study, and the key similarities and differences in their approaches to imposing reporting restrictions. Drawing on the experience of the # LetHerSpeak campaign in Australia, the third section considers critical design choices the Scottish Government faces in legislating for complainer anonymity, including decisions on when a right to anonymity accrues, what offences it applies to, and in what circumstances – and by whom – it can be waived or set aside.
Los judíos en Olisipo (Lisboa). Reflexiones a partir de un posible sello de panadero
Authors: Ávila Ribeiro Ricardo , Neto Nuno , Rebelo Paulo , Bustamante álvarez Macarena 
Published: October 2022

Se presenta un sello circular cerámico con iconografía hebraica localizado en Lisboa en un contexto de época tardorromana. En él aparece una menorah esquematizada. En el presente trabajo, además de realizar un análisis iconográfico, tipológico y funcional del mismo se indaga sobre otros paralelos en clave diacrónica. También el sello ha servido de excusa para reflexionar sobre la presencia de la comunidad judaica en la Hispania romana.
A rapid One-Pot RNA isolation method for simplified clinical detection of SARS-COV-2 infection in India
Authors: Jain Sonia , Bhowmick Arghya , Pandey Anil Kumar 
Published: October 2022

BackgroundWith the rapid increase in COVID-19 cases and the discovery of new viral variants within India over multiple waves, the expensive reagents and time-consuming sample pretreatment required for qPCR analysis have led to slower detection of the disease. The vast Indian population demands an inexpensive and competent sample preparation strategy for rapid detection of the disease facilitating early and efficient containment of the disease.MethodsIn this study, we have surveyed the spread of COVID-19 infection over Faridabad, Haryana, India for 6 months. We also devised a simple single-step method for total RNA extraction using a single tube and compared its efficacy with the commercially available RNA isolation kits.FindingsOur findings suggest that determining Ct values for samples subjected to the One Pot RNA extraction method was as efficient as the commercially available kits but delivers a subtle advantage in a way, by minimizing the cost, labor and sample preparation time.ConclusionThis novel crude RNA extraction method is stable and capable of operating in developing countries like India for low resource settings, without the use of expensive reagents and instruments. Additionally, this method can be further adapted to pooling samples strategies owing to its high sensitivity.
Contemporary learning techniques for healthcare professionals: A narrative review
Authors: Pandit Anand S. 
Published: October 2022

BackgroundAs medical knowledge continues to expand at an accelerated rate, healthcare professionals face a significant challenge in remaining up-to-date. The goal of this narrative review was to present evidence-based learning strategies that could aid postgraduate clinical education.DesignArticles were sought for using PubMed, Ovid, PsychINFO, ERIC databases and only included if relevant to the review objective.ResultsA total of 103 articles, chapters, and books were used to compose this narrative review. An additional 135 articles and chapters were examined in full for context. The review is divided into two sections: (1) strategies that can help foster a learning mind-set; and (2) high-yield practical tools that are effective in formal or informal learning domains.ConclusionIndividual learning is a cornerstone of clinical performance, which influences the quality of care that one can deliver. This review offers a comprehensive set of learning tools for individuals across a variety of settings.
Endogenous GLP-1 levels play an important role in determining the efficacy of DPP-IV Inhibitors in both prediabetes and type 2 diabetes
Authors: Chong Shiau Chin , Sukor Norlela , Robert Sarah Anne , Ng Kim Fong , Kamaruddin Nor Azmi 
Published: October 2022

BackgroundIn contrast to Western population, glucagon-like peptide-1 (GLP-1) levels are preserved in some East Asian population with type 2 diabetes (T2D), explaining why dipeptidyl peptidase-IV (DPP-IV) inhibitors are more effective in East Asians. We assessed whether differences in endogenous GLP-1 levels resulted in different treatment responses to DPP-IV inhibitors in prediabetes and T2D.MethodsA prospective 12-week study using linagliptin 5mg once daily in 50 subjects (28 prediabetes and 22 T2D) who were stratified into high versus low fasting GLP-1 groups. A 75-g oral glucose tolerance test (OGTT) was performed at week 0 and 12. Primary outcomes were changes in HbA1c, fasting and post-OGTT glucose after 12 weeks. Secondary outcomes included changes in insulin resistance and beta cell function indices.ResultsThere was a greater HbA1c reduction in subjects with high GLP-1 compared to low GLP-1 levels in both the prediabetes and T2D populations [least-squares mean (LS-mean) change of -0.33% vs. -0.11% and -1.48% vs. -0.90% respectively)]. Linagliptin significantly reduced glucose excursion by 18% in high GLP-1 compared with 8% in low GLP-1 prediabetes groups. The reduction in glucose excursion was greater in high GLP-1 compared to low GLP-1 T2D by 30% and 21% respectively. There were significant LS-mean between-group differences in fasting glucose (-0.95 mmol/L), 2-hour glucose post-OGTT (-2.4 mmol/L) in the high GLP-1 T2D group. Improvement in insulin resistance indices were seen in the high GLP-1 T2D group while high GLP-1 prediabetes group demonstrated improvement in beta cell function indices. No incidence of hypoglycemia was reported.ConclusionsLinagliptin resulted in a greater HbA1c reduction in the high GLP-1 prediabetes and T2D compared to low GLP-1 groups. Endogenous GLP-1 level play an important role in determining the efficacy of DPP-IV inhibitors irrespective of the abnormal glucose tolerance states.
TCF7L2 gene associated postprandial triglyceride dysmetabolism- a novel mechanism for diabetes risk among Asian Indians
Authors: Madhu Sri Venkata , Mishra Brijesh Kumar , Mannar Velmurugan , Aslam Mohd , Banerjee Basudev , Agrawal Vivek 
Published: October 2022

AimTCF7L2 gene is believed to increase the risk of T2DM by its effects on insulin secretion. However, the exact mechanism of this enhanced risk is not clearly known. While TCF7L2 gene has been shown to affect lipid metabolism, these effects have remained largely unexplored in the context of diabetes risk.MethodsPostprandial lipid responses to a standardized fat challenge test were performed in 620 Asian Indian subjects (310 with NGT and 310 with T2DM/prediabetes) and compared between the risk and wild genotypes of the rs7903146 TCF7L2 gene. In 30 subjects scheduled to undergo abdominal surgery (10 each with NGT, Prediabetes and T2DM), adipocyte TCF7L2 gene expression was also performed by real time qPCR and confirmed by protein expression in western blot.ResultsT allele of rs7903146 TCF7L2 gene was confirmed as the risk allele for T2DM (OR=1.8(1.2-2.74), p=0.005). TT+CT genotypes of rs7903146 TCF7L2 gene showed significantly higher 4hrTg (p&lt;0.01), TgAUC (p&lt;0.01), peakTg (p&lt;0.01) as well as higher postprandial plasma glucose (p=.006) levels and HOMA-IR (p=0.03) and significantly lower adiponectin levels (p=0.02) as compared to CC genotype. The expression of TCF7L2 gene in VAT was 11-fold higher in prediabetes group as compared to NGT (P&lt;0.01) and 5.7-fold higher in T2DM group as compared to NGT group(P=0.003) and was significantly associated with PPTg and glucose levels.ConclusionThere is significant PPTg dysmetabolism associated with the risk allele of rs7903146 polymorphism as well as adipocyte expression of TCF7L2 gene. Significant upregulation of TCF7L2 gene expression in VAT that correlates with PPTg and glycaemia is also seen in Asian Indians with glucose intolerance. Modulation of PPTg metabolism by TCF7L2 gene and the resultant PPHTg may be a novel mechanism that contributes to its diabetes risk in them.
Using Bayesian networks to map winter habitat for mountain goats in coastal British Columbia, Canada
Authors: Wilson Steven F. , Nietvelt Cliff , Taylor Shawn , Guertin Daniel A. 
Published: October 2022

The mountain goat (Oreamnos americanus) is an iconic wildlife species of western North America that inhabits steep and largely inaccessible terrain in remote areas. They are at risk from human disturbance, genetic isolation, climate change, and a variety of other stressors. Managing populations is challenging and mountain goats are particularly difficult and expensive to inventory. As a result, biologists often rely on models to estimate the species’ abundance and distribution in remote areas. We used landscape characteristics evident at point locations of mountain goat visual observations, tracks, and telemetry locations, along with random locations, to learn the structure and parameters of a Bayesian network that predicted the suitability of habitats for mountain goats. We then used the model to map habitat suitability across 285,000 km2 of potential habitat in mountain ranges of the south and central Canadian Pacific coast. Steep slopes, forest cover characteristics, and snow depth were the important drivers. Modeling the system as a Bayesian network provided several advantages over more common regression methods because input variables were heterogenous (i.e., a mix of discrete and continuous), autocorrelated, and animals exhibited non-linear responses to landscape conditions. These common characteristics of ecological data routinely violate the assumptions of parametric linear models, which are commonly used to map habitat suitability from animal observations.
Role of copper ionophore–induced death in immune microenvironment and clinical prognosis of ccRCC: An integrated analysis
Authors: Xia Shunyao , Jia Haixing , Qian Zhipeng , Xiu Youcheng 
Published: October 2022

Background: Clear cell renal cell carcinoma (ccRCC) is a malignancy with a high incidence rate and poor prognosis worldwide. Copper ionophore–induced death (CID) plays an important role in cancer progression.Methods: One training and three validation datasets were acquired from TCGA, GEO and ArrayExpress. K-means clustering was conducted to identify the CID subtypes. The ESTIMATE and CIBERSORT algorithms were employed to illustrate the immune microenvironment of ccRCC. LASSO Cox regression was applied to construct the CID feature-based prognostic model. The immunotherapy cohort was acquired from the literature to explore the potential risk scores for predicting immunotherapy responsiveness.Results: Two CID-related cancer subtypes of ccRCC were identified that performed different immune microenvironment characteristics and prognosis. Based on the identified subtypes, we analyzed the biological heterogeneity and constructed a gene prognostic model. The prognostic model performed well in one training dataset, three validation datasets, and different clinical pathological groups. The prognostic model has a good potential for predicting cancer immune features and immunotherapy responsiveness.Conclusion: CID plays an important role in the tumor microenvironment progression of ccRCC. The robust gene prognostic model developed can help predict cancer prognosis, immune features, and immunotherapy responsiveness.