bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic therapeutic care pathway for pediatric food allergies and intolerances in Italy: a joint position paper by the Italian Society for Pediatric Gastroenterology Hepatology and Nutrition (SIGENP) and the Italian Society for Pediatric Allergy and Immunology (SIAIP)
Authors: Berni Canani Roberto , Caffarelli Carlo , Calvani Mauro , Martelli Alberto , Carucci Laura , Cozzolino Tommaso , Alvisi Patrizia , Agostoni Carlo , Lionetti Paolo , Marseglia Gian Luigi 
Published: June 2022

AbstractEpidemiologic data suggest an increased prevalence of pediatric food allergies and intolerances (FAIs) during the last decades. This changing scenario has led to an increase in the overall healthcare costs, due to a growing demand for diagnostic and treatment services. There is the need to establish Evidence-based practices for diagnostic and therapeutic intervention that could be adopted in the context of public health policies for FAIs are needed.This joint position paper has been prepared by a group of experts in pediatric gastroenterology, allergy and nutrition from the Italian Society for Pediatric Gastroenterology Hepatology and Nutrition (SIGENP) and the Italian Society for Pediatric Allergy and Immunology (SIAIP). The paper is focused on the Diagnostic Therapeutic Care Pathway (DTCP) for pediatric FAIs in Italy.
The effect of a probiotic on gastrointestinal symptoms due to menstruation in healthy adult women on oral contraceptives: randomized, double-blind, placebo-controlled trial protocol
Authors: Judkins Taylor C. , Oula Marie-Laure , Sims Shireen Madani , Langkamp-Henken Bobbi 
Published: June 2022

Abstract
Introduction
For many women, uncomfortable and stressful symptoms accompany the menstrual cycle each month, sometimes in a debilitating manner. Previous studies have reported that gastrointestinal symptoms in healthy women significantly differ by the day of the menstrual cycle, but few studies have assessed interventions intended to minimize these symptoms. Probiotics supplements have been shown to attenuate gastrointestinal symptom severity as well as self-reported feelings of stress in various populations. This study evaluates the effect of a probiotic on abdominal pain and gastrointestinal symptoms in healthy women who take an oral contraceptive, have regular menses, and typically experience these symptoms during menstruation with the primary aim being change in abdominal pain intensity related to the menstrual cycle with probiotic versus placebo supplementation.

Methods and analysis
In this randomized, double-blind, placebo-controlled parallel study, participants will receive either a probiotic or placebo supplement. Participants will begin answering questionnaires approximately 7 days before the start of menstruation (i.e., active bleeding), and 3 days later, they will begin consuming the study supplement for 8 weeks. The questionnaires administered will collect data about abdominal pain severity (primary outcome) and duration related to the menstrual cycle, digestive health, dietary intake, stress, and digestion-associated quality-of-life. A subgroup of women will provide weekly vaginal swabs and stool samples to examine the effect of the probiotic supplement on microbiota composition and diversity for exploratory purposes. Two-sided tests using a linear model and a type I error rate of α = 0.05 will be employed to test all hypotheses. Continuous variables will be presented as means with standard errors and categorical variables, as counts or proportions.

Ethics and dissemination
This study was reviewed and approved by the University of Florida Institutional Review Board 01. Written informed consent will be obtained from all participants prior to any study activities. Study findings will be disseminated at scientific conferences and publication in the trial registry or in a peer-reviewed journal. Any protocol amendments will be reported in the final manuscript of this study.

Trial registration
ClinicalTrials.gov NCT04457401. Registered prospectively on 07 July 2020. The trial was completed in December of 2021.

Protocol version
V4.0 (11-04-2020)

Trial status
Currently recruiting. Recruitment began in November 2020 and extend until December 2021.
Cellulose polymers with β-amino ester pendant group: design, synthesis, molecular docking and application in adsorption of toxic metals from wastewater
Authors: Nairat Noor , Hamed Othman , Berisha Avni , Jodeh Shehdeh , Algarra Manuel , Azzaoui Khalil , Dagdag Omar , Samhan Subhi 
Published: June 2022

AbstractBackgroundCellulose polymers with multidentate chelating functionalities that have high efficiency for toxic metal ions present in water were designed, synthesized, and analyzed. The synthesis was carried out by reacting microcrystalline cellulose extracted from the solid waste of the olive industry with tert-Butyl acetoacetate (Cell-AA), produced cellulose with β-ketoester functionality was then reacted with aniline and the amino acid glycine to produce Cell-β-AN and Cell-β-GL, respectively.ResultsThe adsorption efficiency of the three polymers toward Pb(II) and various toxic metal ions present in sewage was evaluated as a function of adsorbent dose, time, temperature, pH value, and initial ion concentration to determine optimum adsorption conditions. The three polymers showed excellent efficiency toward about 20 metal ions present in a sewage sample collected from the sewer. The adsorption process follows the Langmuir adsorption isotherm model with a second-order of adsorption rate, the calculated qe values (2.675, 15.252, 20.856 mg/g) were close to the experimental qe values (2.133, 13.91, 18.786 mg/g) for the three polymers Cell-AA, Cell-β-AG and Cell-β-AN, respectively. Molecular Dynamic (MD) and Monte Carlo (MC) simulations were performed on the three polymers complexed with Pb(II).ConclusionThe waste material of the olive industry was used as a precursor for making the target cellulose polymers with β-Amino Ester Pendant Group. The polymer was characterized by SEM, proton NMR, TGA, and FT-IR spectroscopy. The efficacy of adsorption was quantitative for metal ions present in a real sample of wastewater and the efficiency didn’t drop even after 7 cycles of use. The results indicate the existence of strong complexation. The thermodynamic study results showed a spontaneous bonding between of Pb(II) and the polymers pendant groups expressed by the negative value of the Gibbs free energy.
On Mann implicit composite subgradient extragradient methods for general systems of variational inequalities with hierarchical variational inequality constraints
Authors: Ceng Lu-Chuan , Yao Jen-Chih , Shehu Yekini 
Published: June 2022

AbstractIn a real Hilbert space, let the VIP, GSVI, HVI, and CFPP denote a variational inequality problem, a general system of variational inequalities, a hierarchical variational inequality, and a common fixed-point problem of a countable family of uniformly Lipschitzian pseudocontractive mappings and an asymptotically nonexpansive mapping, respectively. We design two Mann implicit composite subgradient extragradient algorithms with line-search process for finding a common solution of the CFPP, GSVI, and VIP. The suggested algorithms are based on the Mann implicit iteration method, subgradient extragradient method with line-search process, and viscosity approximation method. Under mild assumptions, we prove the strong convergence of the suggested algorithms to a common solution of the CFPP, GSVI, and VIP, which solves a certain HVI defined on their common solutions set.
The 2019 Mw 7.0 Banten, Indonesia, intraslab earthquake: investigation of the coseismic slip, tsunami modelling and Coulomb stress change
Authors: Gunawan Endra , Kongko Widjo , Kholil Munawar , Widyantoro Bayu Triyogo , Widiyantoro Sri , Supendi Pepen , Hanifa Nuraini Rahma , Anjasmara Ira Mutiara , Pratama Cecep , Gusman Aditya Riadi 
Published: June 2022

AbstractThe 2019 Mw 7.0 Banten, Indonesia, earthquake occurred at a 49 km depth in a relatively unknown region, where the geological structure did not clearly show the fault. In this study, we use the Global Navigation Satellite System data to analyse the fault source of the earthquake. Following the earthquake’s focal mechanism, we modelled a total of four fault models using two possible fault strikes, with each of the fault strikes investigated for shallow top depth and deeper top depth. This study also utilises the tide gauge data to confirm the tsunami waveform, modelled using the estimated coseismic slip. We present evidence of the shallow rupture of the 2019 Mw 7.0 Banten, Indonesia, intraslab earthquake from an ENE-WSW fault direction. The tsunami modelling of a shallow top depth of an ENE-WSW fault direction is a better fit in predicting the tide gauge waveform. We also present evidence that the 2019 Banten intraslab earthquake generated very few aftershocks for a magnitude 7-class earthquake. The stress transfer of a shallow rupture ENE- WSW fault model was able to explain the relocated two weeks of aftershocks.
Spontaneous subarachnoid hemorrhage caused by ruptured aneurysm of basilar trunk perforator: a case report and literature review
Authors: Wu Yao , Li Zhaoliang , Yang Dehong , Wu Tao , Chen Ailin , Dai Chungang , Zhu Qing 
Published: June 2022

Abstract
Background
Aneurysm of basilar perforator was rarely reported in the literature. It is difficult to treat due to its small size and deep-seated location. Excessive treatment may cause complications that resulted from ischemic events of parent perforators. Therefore, it is important to make clinical strategy for such patients to improve the prognosis.

Case presentation
One case, who presented as spontaneous subarachnoid hemorrhage, despite the negative result in computed tomography angiography firstly, was diagnosed angiographically as a ruptured aneurysm of the basilar perforator. A good clinical outcome of the case was achieved during the follow-up after conservative observation for 2 months, as well as the disappearance of previous lesion from angiography.

Conclusions
Aneurysm located at perforator of basilar trunk was rare and difficult to treat. Conservative observation for certain cases with periodic angiography follow-up was considered in order to prevent the patients from potential iatrogenic effects.
A nutraceutical product, extracted from Cannabis sativa, modulates voltage-gated sodium channel function
Authors: Milligan Carol J. , Anderson Lyndsey L. , Bowen Michael T. , Banister Samuel D. , McGregor Iain S. , Arnold Jonathon C. , Petrou Steven 
Published: June 2022

Abstract
Background
Purified cannabidiol (CBD), a non-psychoactive phytocannabinoid, has gained regulatory approval to treat intractable childhood epilepsies. Despite this, artisanal and commercial CBD-dominant hemp-based products continue to be used by epilepsy patients. Notably, the CBD doses used in these latter products are much lower than that found to be effective in reducing seizures in clinical trials with purified CBD. This might be because these CBD-dominant hemp products contain other bioactive compounds, including phytocannabinoids and terpenes, which may exert unique effects on epilepsy-relevant drug targets. Voltage-gated sodium (NaV) channels are vital for initiation of neuronal action potential propagation and genetic mutations in these channels result in epilepsy phenotypes. Recent studies suggest that NaV channels are inhibited by purified CBD. However, the effect of cannabis-based products on the function of NaV channels is unknown.

Methods
Using automated-planar patch-clamp technology, we profile a hemp-derived nutraceutical product (NP) against human NaV1.1–NaV1.8 expressed in mammalian cells to examine effects on the biophysical properties of channel conductance, steady-state fast inactivation and recovery from fast inactivation.

Results
NP modifies peak current amplitude of the NaV1.1–NaV1.7 subtypes and has variable effects on the biophysical properties for all channel subtypes tested. NP potently inhibits NaV channels revealing half-maximal inhibitory concentration (IC50) values of between 1.6 and 4.2 μg NP/mL. Purified CBD inhibits NaV1.1, NaV1.2, NaV1.6 and NaV1.7 to reveal IC50 values in the micromolar range. The CBD content of the product equates to IC50 values (93–245 nM), which are at least an order of magnitude lower than purified CBD. Unlike NP, hemp seed oil vehicle alone did not inhibit NaV channels, suggesting that the inhibitory effects of NP are independent of hemp seed oil.

Conclusions
This CBD-dominant NP potently inhibits NaV channels. Future study of the individual elements of NP, including phytocannabinoids and terpenes, may reveal a potent individual component or that its components interact to modulate NaV channels.
Spotlight on latent tuberculosis infection screening for juvenile idiopathic arthritis in two countries, comparing high and low risk patients
Authors: Piotto Daniela , Nicacio Aline , Neto Agna , Mourão Ana Filipa , Oliveira-Ramos Filipa , Campanilho-Marques Raquel , Guedes Margarida , Cabral Marta , Santos Maria José , Fonseca João Eurico , Canhão Helena , Aikawa Nádia Emi , Oliveira Sheila K. F. , Ferriani Virginia P. L. , Pileggi Gecilmara C. S. , Magalhães Claudia S. , Silva Clovis Artur , Terreri Maria Teresa 
Published: June 2022

Abstract
Background
Rheumatic diseases are associated with an increase in overall risks of tuberculosis (TB). The aim of this study was to evaluate the frequency of TB and the frequency of latent TB infection (LTBI), in clinical practice, for juvenile idiopathic arthritis (JIA) patients from high and low risk of TB incidence endemic countries.

Methods
This is an international, multicenter, cross-sectional, observational study of data collection from Brazil and Registry of Portugal at REUMA.PT. The inclusion criteria were patients with Juvenile Idiopathic Arthritis (JIA) with age ≤ 18 years who underwent screening for Mycobacterium tuberculosis infection [tuberculin skin test (TST) and/or interferon gamma release assay (IGRA)]. Chest X-rays and history of exposure to TB were also assessed.

Results
292 JIA patients were included; mean age 14.3 years, mean disease duration 7.5 years, 194 patients (66.4%) performed only TST, 14 (4.8%) only IGRA and 84 (28.8%) both. The frequency of LTBI (10.6%) and TB was similar between the two countries. The reasons for TB screening were different; in Brazil it was performed more often at JIA onset while in Portugal it was performed when starting Disease Modified Anti-Rheumatic Drugs (DMARD) treatment (p < 0.001). Isoniazid therapy was prescribed in 40 (13.7%) patients (31 with LTBI and 9 with epidemiologic risks and/or due to contact with sick people). Only three patients (1%) developed active TB.

Conclusion
We found nearly 10% of patients with LTBI, a small percentage of patients with treatment due to epidemiologic risks and only 1% with active TB. Distinct reasons and screening methods for LTBI were observed between the two countries.
Anisotropic three-term amplitude-variation-with-offset projections: A case study
Authors: Asaka Michinori 
Published: June 2022

A seismic amplitude-variation-with-offset (AVO) analysis is an important element in seismic reservoir characterization and has been successfully applied in many fields. Traditionally, AVO studies are based on AVO intercept ([Formula: see text]) and gradient ([Formula: see text]) only; curvature ([Formula: see text]) is neglected because it is very sensitive to noise and avoiding noisy [Formula: see text] is very difficult in practice. The recently introduced concept of three-term (3T) AVO projections, combined with continuous improvements in seismic data acquisition and processing, allows interpreters to effectively use [Formula: see text] by optimizing projection angles based not only on rock physics but also on seismic noise. The effectiveness of the 3T AVO projection, in which [Formula: see text], [Formula: see text], and [Formula: see text] are used as the triplet of reflectivities that are summed in the projection, and the impact of random noise on the 3T AVO projection have been investigated using data from an offshore Western Australian field. The 3T AVO projection is used in the framework of the extended elastic impedance. Because the study area is known to have nonnegligible differences in anisotropy parameters between the various lithologies, its impact on [Formula: see text] and [Formula: see text] is taken into account. First, the 3T projection angle targeting lithology fraction logs is optimized using well-log data. Analyses using synthetic seismograms are then performed to investigate the impact of seismic noise. Finally, the method is applied to field data. The results find that (1) [Formula: see text] is an important component of seismic reservoir characterization even if it appears unusable and (2) seismic noise must be taken into account when optimizing the projection angle.
Searching for bridges between psychopathology and real-world functioning in first-episode psychosis: A network analysis from the OPTiMiSE trial
Authors: Dal Santo Francesco , Fonseca-Pedrero Eduardo , García-Portilla María Paz , González-Blanco Leticia , Sáiz Pilar A. , Galderisi Silvana , Giordano Giulia Maria , Bobes Julio 
Published: June 2022

AbstractBackgroundNetwork analysis has been used to explore the interplay between psychopathology and functioning in psychosis, but no study has used dedicated statistical techniques to focus on the bridge symptoms connecting these domains. The current study aims to estimate the network of depressive, negative, and positive symptoms, general psychopathology, and real-world functioning in people with first-episode schizophrenia or schizophreniform disorder, focusing on bridge nodes.MethodsBaseline data from the OPTiMiSE trial were analyzed. The sample included 446 participants (age 40.0 ± 10.9 years, 70% males). The network was estimated with a Gaussian graphical model, using scores on individual items of the positive and negative syndrome scale (PANSS), the Calgary depression scale for schizophrenia, and the personal and social performance scale. Stability, strength centrality, expected influence (EI), predictability, and bridge centrality statistics were computed. The top 20% scoring nodes on bridge strength were selected as bridge nodes.ResultsNodes from different rating scales assessing similar psychopathological and functioning constructs tended to cluster together in the estimated network. The most central nodes (EI) were Delusions, Emotional Withdrawal, Depression, and Depressed Mood. Bridge nodes included Depression, Conceptual Disorganization, Active Social Avoidance, Delusions, Stereotyped Thinking, Poor Impulse Control, Guilty Feelings, Unusual Thought Content, and Hostility. Most of the bridge nodes belonged to the general psychopathology subscale of the PANSS. Depression (G6) was the bridge node with the highest value.ConclusionsThe current study provides novel insights for understanding the complex phenotype of psychotic disorders and the mechanisms underlying the development and maintenance of comorbidity and functional impairment after psychosis onset.
Developing and deploying an efficient genotyping workflow for accelerating maize improvement in developing countries
Authors: Offornedo Queen , Menkir Abebe , Babalola Deborah , Gedil Melaku 
Published: June 2022

Background: Molecular breeding is an essential tool for accelerating genetic gain in crop improvement, towards meeting the need to feed an ever-growing world population. Establishing low-cost, flexible genotyping platforms in small, public and regional laboratories can stimulate the application of molecular breeding in developing countries. These laboratories can serve plant breeding projects requiring low- to medium-density markers for marker-assisted selection (MAS) and quality control (QC) activities. Methods: We performed two QC and MAS experiments consisting of 637 maize lines, using an optimised genotyping workflow involving an in-house competitive allele-specific PCR (KASP) genotyping system with an optimised sample collection, preparation, and DNA extraction and quantitation process. A smaller volume of leaf-disc size plant samples was collected directly in 96-well plates for DNA extraction, using a slightly modified CTAB-based DArT DNA extraction protocol. DNA quality and quantity analyses were performed using a microplate reader, and the KASP genotyping and data analysis was performed in our laboratory. Results: Applying the optimized genotyping workflow expedited the QC and MAS experiments from over five weeks (when outsourcing) to two weeks and eliminated the shipping cost. Using a set of 28 KASP single nucleotide polymorphisms (SNPs) validated for maize, the QC experiment revealed the genetic identity of four maize varieties taken from five seed sources. Another set of 10 KASP SNPs was sufficient in verifying the parentage of 390 F1 lines. The KASP-based MAS was successfully applied to a maize pro-vitamin A (PVA) breeding program and for introgressing the aflatoxin resistance gene into elite tropical maize lines. Conclusion: This improved workflow has helped accelerate maize improvement activities of IITA's Maize Improvement Program and facilitated DNA fingerprinting for tracking improved crop varieties. National Agricultural Research Systems (NARS) in developing countries can adopt this workflow to fast-track molecular marker-based genotyping for crop improvement.
Validation of a lithium-ion commercial battery pack model using experimental data for stationary energy management application
Authors: Foles Ana , Fialho Luís , Horta Pedro , Collares-Pereira Manuel 
Published: June 2022

Background: A cost-effective solution for the design of distributed energy storage systems implies the development of battery performance models yielding a suitable representation of its dynamic behaviour under realistic operation conditions.Methods: In this work, a lithium-ion battery (LIB) is tested to be further modelled and integrated into an existing energy management control system. This specific LIB (5.0 kW /9.8 kWh) is integrated with a commercial inverter and solar photovoltaic (PV) system (3.3 kWp) as part of a microgrid that is also encompassing other energy storage technologies at the University of Évora, Pole of INIESC – National Research Infrastructure for Solar Energy Concentration. A testing protocol fully characterizes the battery and the inverter efficiency to describe their performance better. Then, a battery model is built upon both the existent LIB description and experimental fitting regression. The model allows obtaining the voltage curve, the internal resistance (i.e., to describe instantaneous voltage drop/rise and transients), and the state of charge (SOC) and/or energy capacity based on the current input. The developed model is validated through the comparison with the experimental results.Results: The model approach presented a higher voltage RMSE (root mean square error) of 5.51 V and an MRE (maximum relative error) of 5.68 % in the discharge state. Regarding SOC, the MRE obtained was approximately 6.82 %. In the charge state, the highest RMSE voltage was 5.27 V, with an MRE of 6.74 %. Concerning SOC, the MRE obtained was approximately 6.53 %. Conclusions: The developed model is validated through the comparison with experimental results. Based on computational effort, simplicity of use and the associated model error, the approach is validated to the regular conditions of the commercial battery pack to be incorporated in the next research step, following a bottom-up modelling approach for an increasingly more complex smart grid.