bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinct contributions of ventral CA1/amygdala co-activation to the induction and maintenance of synaptic plasticity
Authors: Chong Yee Song , Wong Lik-Wei , Gaunt Jessica , Lee Yan Jun , Goh Cai Shan , Morris Richard G M , Ch’ng Toh Hean , Sajikumar Sreedharan 
Published: February 2022

Abstract
The amygdala is known to modulate hippocampal synaptic plasticity. One role could be an immediate effect of basolateral amygdala (BLA) in priming synaptic plasticity in the hippocampus. Another role could be through associative synaptic co-operation and competition that triggers events involved in the maintenance of synaptic potentiation. We present evidence that the timing and activity level of BLA stimulation are important factors for the induction and maintenance of long-term potentiation (LTP) in ventral hippocampal area CA1. A 100 Hz BLA co-stimulation facilitated the induction of LTP, whereas 200 Hz co-stimulation attenuated induction. A 100 Hz BLA co-stimulation also caused enhanced persistence, sufficient to prevent synaptic competition. This maintenance effect is likely through translational mechanisms, as mRNA expression of primary response genes was unaffected, whereas protein level of plasticity-related products was increased. Further understanding of the neural mechanisms of amygdala modulation on hippocampus could provide insights into the mechanisms of emotional disorders.
Ambroxol reverses tau and α-synuclein accumulation in a cholinergic N370S GBA1 mutation model
Authors: Yang Shi Yu , Taanman Jan-Willem , Gegg Matthew , Schapira Anthony H V 
Published: February 2022

Abstract
Cognitive impairment is a common non-motor complication of Parkinson’s disease (PD). Glucocerebrosidase gene (GBA1) variants are found in 10–15% of PD cases and are numerically the most important risk factor for PD and dementia with Lewy bodies. Accumulation of α-synuclein and tau pathology is thought to underlie cognitive impairment in PD and likely involves cholinergic as well as dopaminergic neurons. Neural crest stem cells were isolated from both PD patients with the common heterozygous N370S GBA1 mutation and normal subjects without GBA1 mutations. The stem cells were used to generate a cholinergic neuronal cell model. The effects of the GBA1 variant on glucocerebrosidase (GCase) protein and activity, and cathepsin D, tau and α-synuclein protein levels in cholinergic neurons were examined. Ambroxol, a GCase chaperone, was used to investigate whether GCase enhancement was able to reverse the effects of the GBA1 variant on cholinergic neurons. Significant reductions in GCase protein and activity, as well as in cathepsin D levels, were found in GBA1 mutant (N370S/WT) cholinergic neurons. Both tau and α-synuclein levels were significantly increased in GBA1 mutant (N370S/WT) cholinergic neurons. Ambroxol significantly enhanced GCase activity and decreased both tau and α-synuclein levels in cholinergic neurons. GBA1 mutations interfere with the metabolism of α-synuclein and tau proteins and induce higher levels of α-synuclein and tau proteins in cholinergic neurons. The GCase pathway provides a potential therapeutic target for neurodegenerative disorders related to pathological α-synuclein or tau accumulation.
Similar Clinical Improvement Rates Among Biologic Drug Classes in Crohn’s Disease: Systematic Review and Meta-Regression
Authors: Hanžel Jurij , Sedano Rocio , Jeyarajah Jenny , Zou Guangyong , McFarlane Stefanie C , Ma Christopher , Jairath Vipul 
Published: February 2022

Lay Summary
We conducted a systematic review and metaregression of pivotal Crohn’s disease trials to evaluate the rates of change in Crohn’s Disease Activity Index scores in patients receiving biologic treatments. The speed of clinical improvement was similar among biologic drug classes.
Prop of Ribbon Hypergraphs and Strongly Homotopy Involutive Lie Bialgebras
Authors: Merkulov Sergei 
Published: February 2022

Abstract
For any integer $d$, we introduce a prop ${{\mathcal {R}}}{{\mathcal {H}}} ra_d$ of oriented ribbon hypergraphs (in which “edges” can connect more than two vertices) and prove that it admits a canonical morphism of props, $$ \begin{align*} & {\mathcal{H}}\textit{olieb}_{d}^\diamond \longrightarrow {{\mathcal{R}}}{{\mathcal{H}}} ra_d, \end{align*}$$${\mathcal {H}}\textit {olieb}_{d}^\diamond $ being the (degree shifted) minimal resolution of prop of involutive Lie bialgebras, which is nontrivial on every generator of ${\mathcal {H}}\textit {olieb}_{d}^\diamond $. We obtain two applications of this general construction. First we show that for any graded vector space $W$ equipped with a family of cyclically (skew)symmetric higher products, $$ \begin{align*} & \Theta_n: (\otimes^n W[d])_{{{\mathbb{Z}}}_n} \longrightarrow {{\mathbb{K}}}[1+d], \ \ \ \ \ n\geq 1, \end{align*}$$the associated vector space of cyclic words $Cyc(W)=\oplus _{n\geq 0} (\otimes ^n W)_{{{\mathbb {Z}}}_n} $ has a combinatorial ${\mathcal {H}}\textit {olieb}_{d}^\diamond $-structure. As an illustration, we construct for each natural number $N\geq 1$ an explicit combinatorial strongly homotopy involutive Lie bialgebra structure on the vector space of cyclic words in $N$ graded letters, which extends the well-known Schedler’s necklace Lie bialgebra structure from the formality theory of the Goldman–Turaev Lie bialgebra in genus zero. Second, we introduced new (in general, nontrivial) operations in string topology. Given any closed connected and simply connected manifold $M$ of dimension $\geq 4$. We show that the reduced equivariant homology $\bar {H}_{\bullet }^{S^1}(LM)$ of the spacej $LM$ of free loops in $M$ carries a canonical representation of the dg prop ${\mathcal {H}}\textit {olieb}^\diamond _{2-n}$ on $\bar {H}_{\bullet }^{S^1}(LM)$ controlled by four ribbon hypergraphs explicitly shown in this paper.
Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Against SARS-CoV-2 After Natural Infection Is More Potent Than After Vaccination
Authors: Rieke Gereon J , van Bremen Kathrin , Bischoff Jenny , ToVinh Michael , Monin Malte B , Schlabe Stefan , Raabe Jan , Kaiser Kim M , Finnemann Claudia , Odainic Alexandru , Kudaliyanage Anushka , Latz Eicke , Strassburg Christian P , Boesecke Christoph , Schmidt Susanne V , Krämer Benjamin , Rockstroh Jürgen K , Nattermann Jacob 
Published: February 2022

Abstract
We compared the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-specific antibodies to induce natural killer cell-mediated antibody-dependent cellular cytotoxicity (ADCC) in patients with natural infection and vaccinated persons. Analyzing plasma samples from 39 coronavirus disease 2019 (COVID-19) patients and 11 vaccinated individuals, significant induction of ADCC could be observed over a period of more than 3 months in both vaccinated and recovered individuals. Although plasma antibody concentrations were lower in recovered patients, we found antibodies elicited by natural infection induced a significantly stronger ADCC response compared to those induced by vaccination, which may affect protection conferred by vaccination.
Omadacycline pharmacokinetics and soft-tissue penetration in diabetic patients with wound infections and healthy volunteers using in vivo microdialysis
Authors: Gill Christian M , Fratoni Andrew J , Shepard Ashley K , Kuti Joseph L , Nicolau David P 
Published: February 2022

Abstract

Objectives
We assessed the plasma and soft-tissue pharmacokinetic exposure of omadacycline in infected patients with diabetic foot infection (DFI) and healthy volunteers using in vivo microdialysis.

Methods
Eight patients and six healthy volunteers were enrolled and received an omadacycline IV loading dose (200 mg) followed by two oral doses (300 mg) every 24 h. Microdialysis catheters were placed in the soft tissue near the infected diabetic foot wound (patients) or thigh (healthy volunteers). Plasma and dialysate fluid samples were collected, starting immediately prior to the third dose and continued for 24 h post-dose. Protein binding was determined by ultracentrifugation.

Results
The mean ± SD omadacycline pharmacokinetic parameters in plasma for infected patients and healthy volunteers were: Cmax, 0.57 ± 0.15 and 1.14 ± 0.26 mg/L; t½, 16.19 ± 5.06 and 25.34 ± 12.92 h; and total omadacycline AUC0–24, 6.27 ± 1.38 and 14.06 ± 3.40 mg·h/L, respectively. The omadacycline mean plasma free fraction was 0.21 and 0.20 for patients and healthy volunteers, corresponding to free plasma AUC0–24 of 1.13 ± 0.37 and 2.78 ± 0.55 mg·h/L, respectively. Omadacycline tissue AUC0–24 was 0.82 ± 0.38 and 1.37 ± 0.48 mg·h/L for patients and volunteers, respectively.

Conclusions
The present study describes the plasma and soft-tissue exposure of omadacycline in patients with DFI and healthy volunteers. Integrating these data with the microbiological, pharmacokinetic/pharmacodynamic and clinical efficacy data is foundational to support clinical assessments of omadacycline efficacy specifically for DFI. This, coupled with the once-daily oral administration, suggests omadacycline could be an advantageous translational therapy for the hospital and outpatient setting.
Effects of α-glycerol monolaurate on intestinal morphology, nutrient digestibility, serum profiles, and gut microbiota in weaned piglets
Authors: Li Longxian , Wang Huakai , Zhang Nan , Zhang Tuan , Ma Yongxi 
Published: February 2022

Abstract
This experiment was conducted to investigate the effects of dietary supplementation of α-glycerol monolaurate (α-GML) on the growth performance, nutrient digestibility, serum profiles, intestinal morphology, and gut microbiota of weaned piglets. A total of 96 healthy 28-d-old (Duroc × Landrace × Yorkshire) weaned piglets with body weight of 8.34 ± 0.05 kg were randomly divided into 2 treatment groups with 6 replicate pens and 8 piglets per pen. The control group was fed a basal diet and the experimental group was fed the basal diet supplemented with 1,000 mg/kg α-GML. The experiment lasted for 28 d. Dietary supplementation with α-GML had no effect on average daily gain, average daily feed intake, or gain to feed ratio in piglets (P &gt; 0.05); however, it reduced (P &lt; 0.05) diarrhea rate of piglets on days 15 to 28. The apparent total tract digestibility of dry matter (DM), crude protein (CP), ether extract (EE), and gross energy (GE) on day 14, and DM, organic matter, CP, EE, and GE on day 28 increased (P &lt; 0.05) with α-GML supplementation. Moreover, higher (P &lt; 0.05) glutathione peroxidase activity and interleukin-10 (IL-10) concentration, and lower (P &lt; 0.05) malondialdehyde and tumor necrosis factor-α concentrations were observed in piglets supplemented with α-GML compared with the control group on day 14. Compared with the control group, the villus height/crypt depth in the duodenum and villus height in the jejunum and ileum were significantly greater (P &lt; 0.05) in the α-GML group. Dietary α-GML supplementation significantly increased (P &lt; 0.05) the relative abundance of Firmicutes, while decreasing (P &lt; 0.05) Bacteroidota and Campilobacterota in the cecal contents; significantly increased (P &lt; 0.05) the relative proportion of Lactobacillus and Blautia species, reduced (P &lt; 0.05) Eubacterium_rectale_ATCC_33656, Campylobacter, and uncultured_bacterium_Alloprevotella species. Thus, dietary α-GML supplementation at 1,000 mg/kg reduces diarrhea rate, improves intestinal morphology, nutrient digestibility, antioxidant capacity, and immune status, and ameliorates gut microbiota in weaned piglets.
Direct and indirect roles of GRWD1 in the inactivation of p53 in cancer
Authors: Ichikawa Mai Koizumi , Saitoh Masao 
Published: February 2022

Abstract
Glutamate-rich WD40 repeat containing 1 (GRWD1), also known as WDR28, interacts with various proteins through its WD domain and is involved in transcription, translation, cell cycle progression, ubiquitin-mediated degradation and DNA replication and repair. Ribosomal protein L11 (RPL11), which directly interacts with MDM2, inhibits MDM2 ubiquitin ligase activity, thus promoting p53 stabilization. Binding of GRWD1 to RPL11 disrupts the interaction between RPL11 and MDM2 and promotes p53 ubiquitination by MDM2. In addition, a recent report by Fujiyama et al. found that GRWD1 also directly interacts with wild-type p53 and suppresses its transcriptional activity. They propose that GRWD1 is a novel tumor-promoting molecule that negatively regulates wild-type p53 via both indirect and direct mechanisms.
Streaming big time series forecasting based on nearest similar patterns with application to energy consumption
Authors: Jiménez-Herrera P , Melgar-GarcÍa L , Asencio-Cortés G , Troncoso A 
Published: February 2022

AbstractThis work presents a novel approach to forecast streaming big time series based on nearest similar patterns. This approach combines a clustering algorithm with a classifier and the nearest neighbours algorithm. It presents two separate stages: offline and online. The offline phase is for training and finding the best models for clustering, classification and the nearest neighbours algorithm. The online phase is to predict big time series in real time. In the offline phase, data are divided into clusters and a forecasting model based on the nearest neighbours is trained for each cluster. In addition, a classifier is trained using the cluster assignments previously generated by the clustering algorithm. In the online phase, the classifier predicts the cluster label of an instance, and the proper nearest neighbours model according to the predicted cluster label is applied to obtain the final prediction using the similar patterns. The algorithm is able to be updated incrementally for online learning from data streams. Results are reported using electricity consumption with a granularity of $10$ minutes for 4-hour-ahead forecasting and compared with well-known online benchmark learners, showing a remarkable improvement in prediction accuracy.
MDL+ a manufacturing description language to describe and control assembling tasks in industry 4.0
Authors: Zamora-Hernandez Mauricio-Andres , Andrez Chaves Ceciliano Jose , Villalobos Granados Alonso , Alejandro Castro Vargas John , Garcia-Rodriguez Jose , Azorin-Lopez Jorge 
Published: February 2022

Abstract
The assembly of products or components by operators in industries is a complex task with recurring problems. In these processes, operators often make errors that can lead to defective products. Therefore, they need to be inspected later to verify their correct assembly. The main problems are caused by several reasons including high employee turnover, lack of experience in manufacturing specific products or confusion in interpreting instructions to assemble similar components. In this paper, a novel structured language aimed to describe the required actions to manufacture a product in industrial assembly environments is presented. The main contribution is to provide a formal language to feed automatic systems that can verify through visual control whether the actions performed by the operator are carried out following the standard described by this language. In general, the use of this formal language will allow to minimize the negative impact of errors during assembly and to reduce waste in many forms in the industry.
Time-Transformed Test for Bubbles under Non-stationary Volatility
Authors: Kurozumi Eiji , Skrobotov Anton , Tsarev Alexey 
Published: February 2022

Abstract
This paper is devoted to testing for bubbles under time-varying non-stationary volatility. Because the limiting distribution of the seminal Phillips, Wu, and Yu (2011) test depends on the variance function and usually requires a bootstrap implementation under heteroskedasticity, we construct the test based on a deformation of the time domain. The proposed test is asymptotically pivotal under the null hypothesis and its limiting distribution coincides with that of the standard test under homoskedasticity, so that the test does not require computationally extensive methods for inference. Appealing finite sample properties are demonstrated through Monte-Carlo simulations. An empirical application demonstrates that the upsurge behavior of cryptocurrency time series in the middle of the sample is partially explained by the volatility change.
Infection by Moniliophthora perniciosa reprograms tomato Micro-Tom physiology, establishes a sink, and increases secondary cell wall synthesis
Authors: Paschoal Daniele , Costa Juliana L , da Silva Eder M , da Silva Fábia B , Capelin Diogo , Ometto Vitor , Aricetti Juliana A , Carvalho Gabriel G , Pimpinato Rodrigo F , de Oliveira Ricardo F , Carrera Esther , López-Díaz Isabel , Rossi Mônica L , Tornisielo Valdemar , Caldana Camila , Riano-Pachon Diego M , Cesarino Igor , Teixeira Paulo J P L , Figueira Antonio 
Published: February 2022

Abstract
Witches’ broom disease of cacao is caused by the pathogenic fungus Moniliophthora perniciosa. By using tomato (Solanum lycopersicum) cultivar Micro-Tom (MT) as a model system, we investigated the physiological and metabolic consequences of M. perniciosa infection to determine whether symptoms result from sink establishment during infection. Infection of MT by M. perniciosa caused reductions in root biomass and fruit yield, a decrease in leaf gas exchange, and down-regulation of photosynthesis-related genes. The total leaf area and water potential decreased, while ABA levels, water conductance/conductivity, and ABA-related gene expression increased. Genes related to sugar metabolism and those involved in secondary cell wall deposition were up-regulated upon infection, and the concentrations of sugars, fumarate, and amino acids increased. 14C-glucose was mobilized towards infected MT stems, but not in inoculated stems of the MT line overexpressing CYTOKININ OXIDASE-2 (35S::AtCKX2), suggesting a role for cytokinin in establishing a sugar sink. The up-regulation of genes involved in cell wall deposition and phenylpropanoid metabolism in infected MT, but not in 35S::AtCKX2 plants, suggests establishment of a cytokinin-mediated sink that promotes tissue overgrowth with an increase in lignin. Possibly, M. perniciosa could benefit from the accumulation of secondary cell walls during its saprotrophic phase of infection.
The progenitor of the Vela pulsar
Authors: Kochanek C S 
Published: February 2022

ABSTRACTWith Gaia parallaxes, it is possible to study the stellar populations associated with individual Galactic supernova remnants (SNRs) to estimate the mass of the exploding star. Here, we analyse the luminous stars near the Vela pulsar and SNR to find that its progenitor was probably ($\mathrel {\raise.3ex\rm{\gt }\lower0.6ex\rm{\sim }}90\rm \,per\,cent$) low mass (8.1–$10.3\, {\rm M}_\odot$). The presence of the O star γ2 Vel a little over 100 pc from Vela is the primary ambiguity, as including it in the analysis volume significantly increases the probability (to 5 per cent) of higher mass ($\gt 20\, {\rm M}_\odot$) progenitors. However, to be a high-mass star associated with γ2 Vel’s star cluster at birth, the progenitor would have to be a runaway star from an unbound binary with an unusually high velocity. The primary impediment to analysing large numbers of Galactic SNRs in this manner is the lack of accurate distances. This can likely be solved by searching for absorption lines from the SNR in stars as a function of distance, a method which yielded a distance to Vela in agreement with the direct pulsar parallax. If Vela was a $10\, {\rm M}_\odot$ supernova in an external galaxy, the 50-pc search region used in extragalactic studies would contain only $\simeq 10\rm \,per\,cent$ of the stars formed in a 50-pc region around the progenitor at birth and $\simeq 90\rm \,per\,cent$ of the stars in the search region would have been born elsewhere.
Deep optical study of the mixed-morphology supernova remnant G 132.7+1.3 (HB3)
Authors: Boumis P , Chiotellis A , Fragkou V , Akras S , Derlopa S , Kopsacheili M , Leonidaki I , Alikakos J , Palaiologou E V , Harvey E , Souropanis D 
Published: February 2022

ABSTRACT
We present optical CCD images of the large supernova remnant (SNR) G 132.7+1.3 (HB3) covering its full extent for the first time, in the emission lines of Hα +[N ii], [S ii], and [O iii], where new and known filamentary and diffuse structures are detected. These observations are supplemented by new low-resolution long-slit spectra and higher resolution images in the same emission lines. Both the flux-calibrated images and spectra confirm that the optical emission originates from shock-heated gas since the [S ii]/Hα &gt; 0.4. Our findings are also consistent with the recently developed emission-line ratio diagnostics for distinguishing SNRs from H ii regions. A multiwavelength comparison among our optical data and relevant observations in radio, X-rays, gamma-rays and CO bands, provided additional evidence on the interaction of HB3 with the surrounding clouds and clarified the borders of the SNR and the adjacent cloud. We discuss the supernova (SN) properties and evolution that led to the current observables of HB3 and we show that the remnant has most likely passed at the pressure driven snowplow phase. The estimated SN energy was found to be (3.7 ± 1.5) × 1051 erg and the current SNR age (5.1 ± 2.1) × 104 yr. We present an alternative scenario according to which the SNR evolved in the wind bubble cavity excavated by the progenitor star and currently is interacting with its density walls. We show that the overall mixed morphology properties of HB3 can be explained if the SN resulted by a Wolf−Rayet progenitor star with mass $\sim \! 34 \rm ~M_{\odot }$.
Hard X-ray luminosity functions of cataclysmic variables: joint Swift/BAT and Gaia data
Authors: Suleimanov Valery F , Doroshenko Victor , Werner Klaus 
Published: February 2022

ABSTRACT
Cataclysmic variables (CVs) are the most numerous population among the Galactic objects emitting in hard X-rays. Most probably, they are responsible for the extended hard X-ray emission of the Galactic ridge and the central Galactic regions. Here, we consider the sample of CVs detected in the all-sky hard X-ray Swift/BAT survey, which were also detected by Gaia and thus have reliable distance estimates. Using these data, we derive accurate estimates for local number density per solar mass ($\rho _{\rm M} = 1.37^{+0.3}_{-0.16}. \times 10^{-5}\, {\rm M}_\odot ^{-1}$) and luminosity density per solar mass ($\rho _{\rm L} = 8.95^{+0.15}_{-0.1}\times 10^{26}$ erg s−1 M$_\odot ^{-1}$) for objects in the sample. These values appear to be in good agreement with the integrated Galactic ridge X-ray emission and nuclear stellar cluster luminosities. Analysis of the differential luminosity functions dρM/d(log10Lx) and dρL/d(log10Lx) confirms that there are two populations of hard X-ray-emitting CVs. Intermediate polars dominate at luminosities L &gt; 1033 erg s−1, whereas non-magnetic CVs and polars are much more numerous but have lower luminosities on average. As a consequence, the contribution of these populations to the observed hard X-ray luminosity is almost equivalent.