bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the design, conduct and reporting of randomised controlled trials in the haemodialysis population: a scoping review and interview study
Authors: Kaushal Prachi , Adenwalla Sherna F , Lightfoot Courtney J , March Daniel S , Gray Laura J , Burton James O 
Published: March 2022

BackgroundFewer trials are conducted in nephrology than any other specialty, often failing to recruit to target, resulting in unclear evidence affecting translation to clinical practice. This mixed-methods study aims to provide guidance for designing and reporting future randomised controlled trials (RCTs) in the haemodialysis population.MethodA scoping review was conducted. Five databases (MEDLINE, Cumulative Index to Nursing and Allied Health Literature, Embase, Cochrane Central Register of Controlled Trials and ClinicalTrials.gov) were searched for RCTs published between 2013 and 2019 involving prevalent adult haemodialysis patients. Reporting of sample size, recruitment, retention and statistical significance of primary outcome were assessed. Face-to-face semistructured interviews were conducted with individuals from a single centre during dialysis sessions. Interviews were analysed thematically.ResultsOf 786 RCTs identified, 636 (80.9%) were parallel-group, 139 (17.7%) were crossover and 11 (1.4%) were cluster (including one stepped-wedge) design. Sample size justification was reported in 73.1%, 53.8% and 45.5% of parallel-group, crossover and cluster trials, respectively.Target recruitment was achieved by 45.5% of cluster, 53.8% of crossover and 57.7% of parallel-group trials with patient retention at 75.6%, 83.1% and 87.8%, respectively. Primary outcome reached statistical significance in 81.8% of cluster trials, 69.2% of parallel-group and 38.5% of crossover trials.Themes identified from individual interviews: perceptions of the convenience of trial participation; group allocation; perceptions of the benefits and adverse effects of taking part in clinical trials.ConclusionThe recruitment and reporting of RCTs involving people on haemodialysis could be improved. Involvement of all stakeholders and especially participants in the trial design process may address issues around participant burden and ultimately improve the evidence base for clinical practice.
Ultrasound imaging measures of vertebral bony landmark distances are weakly to moderately correlated with intervertebral disc height as assessed by MRI
Authors: Mitchell Ulrike H , Johnson A Wayne , Adams Lauren , Sonnefeld Tayva , Owen Patrick J 
Published: March 2022

ObjectivesTo assess the validity and reliability of ultrasound-derived interbony landmark distances as a proxy for MRI-derived intervertebral disc (IVD) height.MethodsThis is a cross-sectional criterion validity study. Twelve college-aged participants without current low back pain completed both MRI and ultrasound imaging of the lumbar spine in a prone position. Single-segment and multisegment distances between the spinous and mammillary processes at the lumbar segments (L2/L3, L3/L4, L4/L5) were measured twice using ultrasound and analysed digitally. Sagittal slices of the lumbar spine were taken via T1-weighted MRI and IVD height, and the overall distance between IVDs L2/L3 and L4/L5 was imaged once and measured twice.ResultsThere was moderate correlation between multilevel-based measurements (overall distance between L2 and L5, r=0.677, p=0.016) and the average across three levels (r=0.596, p=0.041) when using the spinous processes as bony landmarks. Single-segment measures were not significantly correlated (all: p>0.092). Accuracy and precision were better for the overall MRI-derived distance between the three IVDs from L2 and L5 MRI and the distance measured between the spinous processes L2–L5. There was excellent reliability within multiple measurements at each location, with intraclass correlation coefficient, ICC(3,1), ranging from 0.93 to 0.99 (95% CI 0.82 to 0.99) for ultrasound and from 0.98 to 0.99 (95% CI 0.92 to 0.99) for MRI.ConclusionFindings do not support the use of ultrasound imaging for estimating single-segment IVD height, yet it may be used to measure the change in distance over time with a certain degree of precision based on its excellent reliability.
Multicenter, single-arm, phase II trial of camrelizumab and chemotherapy as neoadjuvant treatment for locally advanced esophageal squamous cell carcinoma
Authors: Liu Jun , Yang Yang , Liu Zhichao , Fu Xiaolong , Cai Xiaoyue , Li Hongxuan , Zhu Li , Shen Yan , Zhang Hong , Sun Yifeng , Chen Hezhong , Yu Bentong , Zhang Renquan , Shao Jinchen , Zhang Ming , Li Zhigang 
Published: March 2022

BackgroundCamrelizumab and chemotherapy demonstrated durable antitumor activity with a manageable safety profile as first-line treatment in patients with advanced esophageal squamous cell carcinoma (ESCC). This study aimed to evaluate the safety and efficacy of camrelizumab plus neoadjuvant chemotherapy, using pathologically complete response (pCR) as primary endpoint, in the treatment for locally advanced ESCC.MethodsPatients with locally advanced but resectable thoracic ESCC, staged as T1b-4a, N2-3 (≥3 stations), and M0 or M1 lymph node metastasis (confined to the supraclavicular lymph nodes) were enrolled. Eligible patients received intravenous camrelizumab (200 mg, day 1) plus nab-paclitaxel (100 mg/m2, day 1, 8, 15) and carboplatin (area under curve of 5 mg/mL/min, day 1) of each 21-days cycle, for two cycles before surgery. The primary endpoint is pCR rate in the per-protocol population. Safety was assessed in the modified intention-to-treat population that was treated with at least one dose of camrelizumab.ResultsFrom November 20, 2019 to December 22, 2020, 60 patients were enrolled. 55 (91.7%) patients completed the full two-cycle treatment successfully. 51 patients underwent surgery and R0 resection was achieved in 50 (98.0%) patients. pCR (ypT0N0) was identified in 20 (39.2%) patients and 5 (9.8%) patients had complete response of the primary tumor but residual disease in lymph nodes alone (ypT0N+). 58 patients (96.7%) had any-grade treatment-related adverse events (TRAEs), with the most common being leukocytopenia (86.7%). 34 patients (56.7%) had adverse events of grade 3 or worse, and one patient (1.7%) occurred a grade 5 adverse event. There was no in-hospital and postoperative 30-day as well as 90-day mortality.ConclusionsThe robust antitumor activity of camrelizumab and chemotherapy was confirmed and demonstrated without unexpected safety signals. Our findings established camrelizumab and chemotherapy as a promising neoadjuvant treatment for locally advanced ESCC.Trial registration numberChiCTR1900026240.
Parenchymal lung abnormalities following hospitalisation for COVID-19 and viral pneumonitis: a systematic review and meta-analysis
Authors: Fabbri Laura , Moss Samuel , Khan Fasihul A , Chi Wenjie , Xia Jun , Robinson Karen , Smyth Alan Robert , Jenkins Gisli , Stewart Iain 
Published: March 2022

IntroductionPersisting respiratory symptoms in COVID-19 survivors may be related to development of pulmonary fibrosis. We assessed the proportion of chest CT scans and pulmonary function tests consistent with parenchymal lung disease in the follow-up of people hospitalised with COVID-19 and viral pneumonitis.MethodsSystematic review and random effects meta-analysis of proportions using studies of adults hospitalised with SARS-CoV-2, SARS-CoV, MERS-CoV or influenza pneumonia and followed up within 12 months. Searches performed in MEDLINE and Embase. Primary outcomes were proportion of radiological sequelae on CT scans; restrictive impairment; impaired gas transfer. Heterogeneity was explored in meta-regression.ResultsNinety-five studies (98.9% observational) were included in qualitative synthesis, 70 were suitable for meta-analysis including 60 SARS-CoV-2 studies with a median follow-up of 3 months. In SARS-CoV-2, the overall estimated proportion of inflammatory sequelae was 50% during follow-up (0.50; 95% CI 0.41 to 0.58; I2=95%), fibrotic sequelae were estimated in 29% (0.29; 95% CI 0.22 to 0.37; I2=94.1%). Follow-up time was significantly associated with estimates of inflammatory sequelae (−0.036; 95% CI −0.068 to –0.004; p=0.029), associations with fibrotic sequelae did not reach significance (−0.021; 95% CI −0.051 to 0.009; p=0.176). Impaired gas transfer was estimated at 38% of lung function tests (0.38 95% CI 0.32 to 0.44; I2=92.1%), which was greater than restrictive impairment (0.17; 95% CI 0.13 to 0.23; I2=92.5%), neither were associated with follow-up time (p=0.207; p=0.864).DiscussionSequelae consistent with parenchymal lung disease were observed following COVID-19 and other viral pneumonitis. Estimates should be interpreted with caution due to high heterogeneity, differences in study casemix and initial severity.PROSPERO registration numberCRD42020183139.
ChiliPDF: Chebyshev interpolation for parton distributions
Authors: Diehl Markus , Nagar Riccardo , Tackmann Frank J. 
Published: March 2022

AbstractParton distribution functions (PDFs) are an essential ingredient for theoretical predictions at colliders. Since their exact form is unknown, their handling and delivery for practical applications relies on approximate numerical methods. We discuss the implementation of PDFs based on a global interpolation in terms of Chebyshev polynomials. We demonstrate that this allows for significantly higher numerical accuracy at lower computational cost compared with local interpolation methods such as splines. Whilst the numerical inaccuracy of currently used local methods can become a nontrivial limitation in high-precision applications, in our approach it is negligible for practical purposes. This holds in particular for differentiation and for Mellin convolution with kernels that have end point singularities. We illustrate our approach for these and other important numerical operations, including DGLAP evolution, and find that they are performed accurately and fast. Our results are implemented in the C++ library ChiliPDF.
Bidirectional Association between Hypertension and NAFLD: A Systematic Review and Meta-Analysis of Observational Studies
Authors: Li Gerui , Peng Yuanyuan , Chen Ze , Li Hang , Liu Danli , Ye Xujun 
Published: March 2022

An increasing body of evidence connects non-alcoholic fatty liver disease (NAFLD) to hypertension. The objective of this systematic review and meta-analysis was to estimate the nature and magnitude of the association between NAFLD and hypertension. We systematically searched PubMed, Embase, Cochrane Library, and Web of Science for observational studies published up to May 1, 2021. Cohort studies that reported data on the association between NAFLD and incident hypertension or between hypertension and incident NAFLD were included. We used random-effects models to conduct meta-analysis on the measures of association from individual studies. A total of 11 studies were eligible for inclusion, among which 4 studies including 25,260 participants reported the association between hypertension and new-onset NAFLD. The presence of hypertension was significantly associated with an increased risk of incident NAFLD (HR 1.63, 95% CI: 1.41–1.88; I2 = 37.6%). On the other hand, 9 studies with data on 46,487 participants analyzed the effects of NAFLD on incident hypertension. Pooled analysis showed that the presence of NAFLD was significantly associated with an increased incidence of hypertension (HR 1.55, 95% CI: 1.29–1.87; I2 = 80.5%). There was significant heterogeneity among the studies in this analysis (

p

< 0.01). Sensitivity analyses showed that the magnitude of the association was significantly different in subgroups stratified by a mean age of participants and geographical location, which explains part of the heterogeneity. In conclusion, this meta-analysis indicates the existence of a bidirectional relationship between NAFLD and hypertension independent of traditional cardiometabolic risk factors.
Dose Escalation Data from the Phase 1 Study of the Liposomal Formulation of Eribulin (E7389-LF) in Japanese Patients with Advanced Solid Tumors
Authors: Sato Jun , Shimizu Toshio , Koyama Takafumi , Iwasa Satoru , Shimomura Akihiko , Kondo Shunsuke , Kitano Shigehisa , Yonemori Kan , Fujiwara Yutaka , Tamura Kenji , Suzuki Takuya , Takase Takao , Nagai Reiko , Yamaguchi Kohei , Semba Taro , Zhao Zi-Ming , Ren Min , Yamamoto Noboru 
Published: March 2022

Abstract

Purpose:
We report the dose-escalation part of a phase I study of liposomal eribulin (E7389-LF) in Japanese patients with advanced solid tumors and no alternative standard therapy.

Patients and Methods:
Patients ≥20 years old were enrolled. E7389-LF doses of 1.0 to 1.5 mg/m2 once every two weeks (Q2W) or 1.0 to 2.5 mg/m2 once every three weeks (Q3W) were planned. The primary objective was to determine the MTD by evaluating dose-limiting toxicities (DLT). Secondary objectives included safety/tolerability assessments, objective response rate (ORR), and progression-free survival; serum biomarker assessment was an exploratory objective.

Results:
Twenty-one patients were enrolled and treated; 12 in the Q3W group (1.0 mg/m2, n = 3; 1.5 mg/m2, n = 3; 2.0 mg/m2, n = 6) and 9 in the Q2W group (1.0 mg/m2, n=3; 1.5 mg/m2, n = 6). The Q3W and Q2W MTDs were 2.0 mg/m2 and 1.5 mg/m2, respectively. One patient receiving 2.0 mg/m2 Q3W had a DLT of grade 3 febrile neutropenia. The most common grade 3 treatment-emergent adverse events were neutropenia (66.7% in Q3W and Q2W) and leukopenia (Q3W, 58.3%; Q2W, 33.3%). One patient in the Q3W group (2.0 mg/m2) and 3 in the Q2W group (1.0 mg/m2, n = 1; 1.5 mg/m2, n = 2) achieved a partial response [overall ORR, 19.0%; 95% confidence interval (CI), 5.4–41.9]. Endothelial [TEK receptor tyrosine kinase (TEK), intercellular adhesion molecule 1 (ICAM1), vascular endothelial growth factor receptor 3 (VEGFR3), platelet/endothelial cell adhesion molecule 1 (PECAM1)], vasculature (collagen IV), and immune-related [interferon gamma (IFNγ), C-X-C motif chemokine ligand 11 (CXCL11), C-X-C motif chemokine ligand 10 (CXCL10)] biomarker levels were increased.

Conclusions:
E7389-LF was well tolerated at 2.0 mg/m2 Q3W and 1.5 mg/m2 Q2W. Considering the toxicity profile of both regimens, the recommended dose was 2.0 mg/m2 Q3W. Expansion cohorts are ongoing.
O ensino da leitura literária na escola básica: perspectivas e desafios a partir da BNCC
Authors: Portolomeos Andrea , Nepomuceno Susana Vieira Rismo 
Published: March 2022

Antonio Candido, no texto O direito à literatura, defende que a leitura do texto literário promove uma experiência humanizadora à medida que o indivíduo tende a se tornar mais empático diante das mais diferentes realidades. A Base Nacional Comum Curricular (BNCC) é homologada em 2017, oferecendo aos professores da educação básica orientações que dialogam com o posicionamento de Candido. Todavia, entra em contradição em suas diretrizes, se distanciando da compreensão do texto literário enquanto material estético. Assim, este artigo promove uma discussão sobre a especificidade do texto e da leitura literária que auxilie o professor na sua prática de sala de aula e ainda reflete sobre as perspectivas e desafios presentes na BNCC no que se refere ao ensino da leitura literária como forma de promover aulas de literatura mais emancipadoras.
When Work Moves: Job Suburbanization and Black Employment
Authors: Miller Conrad 
Published: March 2022

Abstract
This paper examines whether job suburbanization caused declines in black employment rates from 1970 to 2000. I find that black workers are less likely than white workers to work in observably similar jobs that are located further from the central city. Using evidence from establishment relocations, I find that this relationship reflects at least in part the causal effect of job location. At the local labor market level, I find that job suburbanization is associated with substantial declines in black employment rates relative to white employment rates. Evidence from nationally planned highway infrastructure corroborates a causal interpretation.
Strategic or Confused Firms? Evidence from “Missing” Transactions in Uganda
Authors: Almunia Miguel , Hjort Jonas , Knebelmann Justine , Tian Lin 
Published: March 2022

Abstract
Are firms sophisticated maximizers, or do they appear to make mistakes? Using transaction data from Ugandan value-added tax returns, we show that sellers and buyers report different amounts 79% of the time, despite invoices being easily cross-checked. Our estimates suggest that most firms are “advantageous misreporters,” but that 25% are “disadvantageous misreporters” who systematically overreport own sales minus purchases such that their tax liability increases. Similarly, many firms—especially disadvantageous misreporters—fail to VAT-report imported inputs they themselves reported at Customs, increasing their liability. On net, unilateral VAT misreporting cost Uganda about US$384 million in foregone 2013–2016 tax revenue.
Energetics and Mixing of Stratified, Rotating Flow over Abyssal Hills
Authors: Zemskova Varvara E. , Grisouard Nicolas 
Published: March 2022

Abstract
One of the proposed mechanisms for energy loss in the ocean is through dissipation of internal waves, in particular above rough topography where internal lee waves are generated. Rates of dissipation and diapycnal mixing are often estimated using linear internal wave generation theory and a constant value for mixing efficiency. However, previous oceanographic measurements found that nonlinear dynamics may be important close to topography. To investigate the role of nonlinear interactions, we conduct idealized 3D direct numerical simulations (DNS) of steady flow over 1D topography and vary the topographic height, which correlates to the degree of flow nonlinearity. We analyze the spatial distribution of energy transfer rates between internal waves and the nongeostrophic portion of the time-mean flow, and of dissipation and diapycnal mixing rates. In our simulations with taller, more nonlinear topographies, energy transfer rates are similar to previously unexplained oceanographic observations near topography: internal waves gain energy from time-mean flow through horizontal straining and lose energy through vertical shearing. In the tall topography simulations, buoyancy fluxes also play a significant role, consistent with observations but contrary to linear wave theory, suggesting that quasigeostrophy-based approximations and linear theory may not hold in some regions above rough topography. Both dissipation and mixing rates increase with topographic height, but their vertical distributions differ between topographic regimes. As such, the vertical profile of mixing efficiency is different for linear and nonlinear topographic regimes, which may need to be incorporated into parameterizations of small-scale processes in models and estimates of ocean energy loss.
Economic Viability and Emissions of Multimodal Transportation Infrastructure in a Changing Arctic
Authors: Goldstein Michael A. , Lynch Amanda H. , Yan Ruitian , Veland Siri , Talleri William 
Published: March 2022

Abstract
As Arctic open water increases, shipping activity to and from mid- and western Russian Arctic ports to points south has notably increased. A number of Arctic municipalities hope increased vessel traffic will create opportunities to become a major transshipment hub. However, even with more traffic passing these ports, it might still be economically cheaper to offload cargo at a more southern port, which may also result in lower emissions. Ultimately, the question of whether to use a transshipment in the Arctic versus an established major European port is determined by the relative costs (or emissions) of sea versus land travel. This study calculates the relative competitiveness of six Norwegian coastal cities as multimodal hubs for shipments. We quantify the relative prices and CO2 emissions for sea and land travel for routes starting at the Norwegian–Russian sea border with an ultimate destination in central Europe and find that all existing routes are not competitive with routes using the major existing Port of Rotterdam (Netherlands); even with investments in port expansion and modernization, they would be underutilized regardless of an increase in vessel traffic destined for central Europe. We then examine under what relative prices (emissions) these routes become economically viable or result in lower emissions than using existing southern ports. Notably, the cheapest routes generally produce the lowest emissions, and the most expensive routes tend to have the largest emissions. Communities should consider relative competitiveness prior to making large infrastructure investments. While some choices are physically possible, they may not be economically viable.

Significance Statement
Climate change, while disruptive, can also create new opportunities. Many Arctic cities hope to become a major transshipping hub as declining sea ice opens new shipping routes from western and mid-Russian Arctic ports to European ports. This paper quantifies the relative competitiveness of six Norwegian coastal cities as multimodal transportation hubs and finds that they are uncompetitive with the more southern port in Rotterdam (Netherlands). We also show that the most economically competitive routes have lower direct emissions. Thus, while Arctic ports provide critical services in support of local and regional economic activity, even with year-round Arctic navigation Arctic ports’ development into major transshipment hubs for cargo destined for more distant locations may be neither economically viable nor desirable.
Learning About Communication Disorders: Comparison of Two Instructional Methods With Multimedia for Preservice Teachers
Authors: Allen Abigail A. 
Published: March 2022

Content acquisition podcasts (CAPs) are a popular tool in special educator preparation but little is known about their application to communication disorders. This quasi-experimental study investigated the effectiveness of two instructional methods: lecture plus video and a content acquisition podcast (CAP). Participants were undergraduates in early childhood education and special education programs ( N = 62). Participants were assessed on their knowledge and application of communication development and disorders at four time points. Results indicated that the lecture plus video condition was more effective at producing knowledge gains compared to the CAP condition, but both conditions were equally effective at producing gains in application ability at post-test. Neither group maintained their knowledge gains 8 weeks after instruction. Learning condition did not affect participants in the two education programs differently. Implications for teacher preparation are discussed.