bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selectively Coupling Ru Single Atoms to PtNi Concavities for High‐Performance Methanol Oxidation via d‐Band Center Regulation
Authors: Kong Fanpeng , Liu Xiaozhi , Song Yajie , Qian Zhengyi , Li Junjie , Zhang Lei , Yin Geping , Wang Jiajun , Su Dong , Sun Xueliang 
Published: August 2022

AbstractSingle atom tailored metal nanoparticles represent a new type of catalysts. Herein, we demonstrate a single atom‐cavity coupling strategy to regulate performance of single atom tailored nano‐catalysts. Selective atomic layer deposition (ALD) was conducted to deposit Ru single atoms on the surface concavities of PtNi nanoparticles (Ru‐ca‐PtNi). Ru‐ca‐PtNi exhibits a record‐high activity for methanol oxidation reaction (MOR) with 2.01 A mg−1Pt. Also, Ru‐ca‐PtNi showcases a significant durability with only 16 % activity loss. Operando electrochemical Fourier transform infrared spectroscopy (FTIR) and theoretical calculations demonstrate Ru single atoms coupled to cavities accelerate the CO removal by regulating d‐band center position. Further, the high diffusion barrier of Ru single atoms in concavities accounts for excellent stability. The developed Ru‐ca‐PtNi via single atom‐cavity coupling opens an encouraging pathway to design highly efficient single atom‐based (electro)catalysts.
Study on the coating material of hexamethylol melamine modified phenolic resin for casting filter
Authors: Tang Yaoji , Huang Renhe , Yuan Zhenfei 
Published: August 2022

AbstractIn this article, hexamethylol melamine (HMM) modified phenolic resin (PF) coating material was prepared by using thermoplastic PF wastewater. Using alcohol soluble PF, the thermoplastic PF wastewater (containing oxalic acid catalyst), methanol and HMM as raw materials, HMM was methyl etherified by oxalic acid and then modified PF was synthesized. By determination of carbon residue, thermogravimetric analysis (TGA) and differential scanning calorimetry, the influences on the heat resistance of modified PF by the composition of wastewater, composition of melamine formaldehyde (MF) resin, and composition of MF resin modified PF were analyzed. The results showed that the phenol content in wastewater had no effect on the heat resistance. The MF resin modified by HMM with the highest molar ratio of formaldehyde and melamine had the highest heat resistance. And the nitrogen content of the highest thermostable modified PF was 5 wt%. Additional curing agent was not required for HMM modified PF. The possible pyrolysis process was discussed. As a filter coating material, the heat resistance of HMM modified PF was better than that of PF cured with traditional urotropine (HMTA).
Stable nebulization and muco‐trapping properties of regdanvimab/IN‐006 support its development as a potent, dose‐saving inhaled therapy for COVID‐19
Authors: McSweeney Morgan D. , Stewart Ian , Richardson Zach , Kang Hyunah , Park Yoona , Kim Cheolmin , Tiruthani Karthik , Wolf Whitney , Schaefer Alison , Kumar Priya , Aurora Harendra , Hutchins Jeff , Cho Jong Moon , Hickey Anthony J. , Lee Soo Young , Lai Samuel K. 
Published: August 2022

AbstractThe respiratory tract represents the key target for antiviral delivery in early interventions to prevent severe COVID‐19. While neutralizing monoclonal antibodies (mAb) possess considerable efficacy, their current reliance on parenteral dosing necessitates very large doses and places a substantial burden on the healthcare system. In contrast, direct inhaled delivery of mAb therapeutics offers the convenience of self‐dosing at home, as well as much more efficient mAb delivery to the respiratory tract. Here, building on our previous discovery of Fc‐mucin interactions crosslinking viruses to mucins, we showed that regdanvimab, a potent neutralizing mAb already approved for COVID‐19 in several countries, can effectively trap SARS‐CoV‐2 virus‐like particles in fresh human airway mucus. IN‐006, a reformulation of regdanvimab, was stably nebulized across a wide range of concentrations, with no loss of activity and no formation of aggregates. Finally, nebulized delivery of IN‐006 resulted in 100‐fold greater mAb levels in the lungs of rats compared to serum, in marked contrast to intravenously dosed mAbs. These results not only support our current efforts to evaluate the safety and efficacy of IN‐006 in clinical trials, but more broadly substantiate nebulized delivery of human antiviral mAbs as a new paradigm in treating SARS‐CoV‐2 and other respiratory pathologies.
Definition and verification of novel metastasis and recurrence related signatures of ccRCC: A multicohort study
Authors: Jiang Aimin , Pang Qingyang , Gan Xinxin , Wang Anbang , Wu Zhenjie , Liu Bing , Luo Peng , Qu Le , Wang Linhui 
Published: August 2022

AbstractBackgroundCancer metastasis and recurrence remain major challenges in renal carcinoma patient management. There are limited biomarkers to predict the metastatic probability of renal cancer, especially in the early‐stage subgroup. Here, our study applied robust machine‐learning algorithms to identify metastatic and recurrence‐related signatures across multiple renal cancer cohorts, which reached high accuracy in both training and testing cohorts.MethodsClear cell renal cell carcinoma (ccRCC) patients with primary or metastatic site sequencing information from eight cohorts, including one out‐house cohort, were enrolled in this study. Three robust machine‐learning algorithms were applied to identify metastatic signatures. Then, two distinct metastatic‐related subtypes were identified and verified; matrix remodeling associated 5 (MXRA5), as a promising diagnostic and therapeutic target, was investigated in vivo and in vitro.ResultsWe identified five stable metastasis‐related signatures (renin, integrin subunit beta‐like 1, MXRA5, mesenchyme homeobox 2, and anoctamin 3) from multicenter cohorts. Additionally, we verified the specificity and sensibility of these signatures in external and out‐house cohorts, which displayed a satisfactory consistency. According to these metastatic signatures, patients were grouped into two distinct and heterogeneous ccRCC subtypes named metastatic cancer subtype 1 (MTCS1) and type 2 (MTCS2). MTCS2 exhibited poorer clinical outcomes and metastatic tendencies than MTCS1. In addition, MTCS2 showed higher immune cell infiltration and immune signature expression but a lower response rate to immune blockade therapy than MTCS1. The MTCS2 subgroup was more sensitive to saracatinib, sunitinib, and several molecular targeted drugs. In addition, MTCS2 displayed a higher genome mutation burden and instability. Furthermore, we constructed a prognosis model based on subtype biomarkers, which performed well in training and validation cohorts. Finally, MXRA5, as a promising biomarker, significantly suppressed malignant ability, including the cell migration and proliferation of ccRCC cell lines in vitro and in vivo.ConclusionsThis study identified five robust metastatic signatures and proposed two metastatic probability clusters with stratified prognoses, multiomics landscapes, and treatment options. The current work not only provided new insight into the heterogeneity of renal cancer but also shed light on optimizing decision‐making in immunotherapy and chemotherapy.
Long term follow‐up after balloon expandable covered stents implantation for management of transcatheter aortic valve replacement related vascular access complications
Authors: Maurina Matteo , Condello Francesco , Mangieri Antonio , Sanz‐Sanchez Jorge , Stefanini Giulio Giuseppe , Bongiovanni Dario , Cozzi Ottavia , Leone Pier Pasquale , Baggio Sara , Gasparini Gabriele , Pagnotta Paolo , Civilini Efrem , Colombo Antonio , Reimers Bernhard , Regazzoli Damiano 
Published: August 2022

AbstractObjectivesTo report the experience of a high‐volume center with balloon‐expandable (BE) stents implantation to manage vascular complications after transcatheter aortic valve replacement (TAVR).BackgroundDespite increased operator experience and better devices, vascular complications after TAVR are still a major issue and covered stent implantation is often required.MethodsWe retrospectively collected baseline and procedural data about 78 consecutive patients who underwent BE stent implantation to manage a vascular complication after transfemoral TAVR. Primary endpoints were technical success, incidence of new‐onset claudication and need for vascular interventions during long‐term follow‐up. Secondary endpoints included length of hospitalization, in‐hospital and 30‐day mortality, and major postoperative complications.ResultsBE stents implantation to manage vascular complications after TAVR was successfully performed in 96.2% of the cases, with bailout surgery required in two cases. One patient suffered in‐hospital death. Predischarge Doppler Ultrasound revealed no cases of in‐stent occlusion or fracture. At a median follow‐up of 429 days (interquartile range, 89−994 days), no cases of symptomatic leg ischemia were reported and only one patient experienced new‐onset claudication.ConclusionsOur experience showed good periprocedural and long‐term results of BE covered stent implantation to manage vascular complication after TAVR. Their great radial outward force may guarantee effective hemostasis without necessarily being associated with stent deformation/fracture resulting in restenosis or further interventions. More research is needed to define the role of BE covered stents in this setting.
Kinetic Studies of Immobilized Wheat‐Based Alpha‐Naphthyl Acetate Esterase in the Detection of Organophosphate Pesticides
Authors: Nageib Adilah Mohamed , Jameel Ahmad Tariq , Ahmad Farah B. 
Published: August 2022

AbstractOrganophosphate pesticides could inhibit the activity of alpha‐naphthyl acetate esterase (ANAE), which could be the fundamental for biosensor applications. k‐carrageenan was used for immobilization of ANAE extracted from wheat‐based sources. The activity of ANAE was assessed for optimum activity at a range of temperature and pH. Enzyme kinetic studies were performed using Michaelis‐Menten kinetic parameters from Lineweaver‐Burk, Langmuir, and Eddie‐Hofstee. The optimization studies showed that the relative activity of the enzyme remained high, even above 50 °C. kd obtained was very low, which indicates the high sensitivity of ANAE towards pesticides. The kinetic reaction of ANAE showed the promising application of biosensors in the detection of pesticide.
Effect of Particle Size and Coke Formation on n‐Octane Dehydrogenation
Authors: Prucker Tobias , Lamberty Aliena , Thiessen Johannes , König Matthias , Jess Andreas 
Published: August 2022

AbstractThe effect of particle size as well as of coke formation on conversion of intermediate chain length paraffins (C6–C9) to the corresponding olefins was investigated on a promoted Pt catalyst with the model substance n‐octane. Increasing the particle size leads to pore diffusion limitations and thus to a reduction of the activity for paraffin conversion and of the octene selectivity caused by more pronounced formation of consecutive products (aromatics, octadienes). Both effects are adequately predicted by the developed kinetic model. The activity of dehydrogenation declines with the content of coke, but to a lesser extent than the rate of coke formation, which is beneficial regarding the catalyst lifetime. The initial activity is fully recovered by mild coke burn‐off (T < 470 °C).
Survival estimates of childhood malignancies treated at the Mexican telethon pediatric oncology hospital
Authors: Monárrez‐Espino Joel , Romero‐Rodriguez Lourdes , Escamilla‐Asiain Gabriela , Ellis‐Irigoyen Andrea , Cubría‐Juárez María del Pilar , Sematimba Douglas , Rodríguez‐Galindo Carlos , Vega‐Vega Lourdes 
Published: August 2022

AbstractBackgroundPediatric cancer incidence in Mexico is ~160/million/year with leukemias making 49.8% of the cases. While survival rates have been reported in various Mexican studies, no data is available from the Telethon Pediatric Oncology Hospital‐HITO, a nonprofit private institution specialized exclusively in comprehensive pediatric oncology care in the country that closely follows high‐income countries' advanced standards of cancer care.AimTo determine overall survival (OS) and relapse‐free survival (RFS) in patients treated at HITO between December 2013 and February 2018.Methods and resultsSecondary analysis of data extracted from medical records. It included 286 children aged 0–17 years diagnosed with various cancers grouped into three categories based on location: (1) Acute lymphoblastic leukemia (ALL), (2) tumors within the central nervous system (TWCNS), and (3) tumors outside the CNS (TOCNS). OS and RFS rates for patients who completed 1 (n = 230) and 3 (n = 132) years of follow‐up after admission were computed by sex, age, and cancer location, and separately for a subsample (1‐year = 191, 3‐years = 110) who fulfilled the HITO criteria (no prior treatment, underwent surgery/chemotherapy when indicated, and initiated therapy). TOCNS accounted for 45.1%, but ALL was the most frequent single diagnosis with 28%. Three‐year OS for patients with ALL, TWCNS, and TOCNS who fulfilled the HITO criteria were 91.9%, 86.7%, and 79.3%, respectively; for 3‐year RFS these were 89.2%, 60%, and 72.4%. Boys showed slightly higher OS and RFS, but no major differences or trends were seen by age group.ConclusionThis study sets a relevant reference in terms of survival and relapse for children with cancer in Mexico treated at a private oncology center that uses a comprehensive and integrated therapeutic model.
A hybrid soft computing technique for intrusion detection in web and cloud environment
Authors: Maheswari K. G. , Siva C. , Nalinipriya G. 
Published: August 2022

AbstractCloud computing environment contains important, essential, or confidential information; therefore, a security solution is needed to prevent this environment from potential attacks. In short, cloud computing has become one of the most sought after technologies in the field of information technology, and among the most dangerous threats. In this article, we propose a hybrid soft computing technique for intrusion detection in web and cloud environment (ST‐IDS). In ST‐IDS, we illustrate whale integrated slap swarm optimization algorithm for pre‐processing which remove the unwanted/repeated data's in dataset. We introduce new clustering technique based on modified tug‐of‐war optimization algorithm which groups the data in different segments. Then, we develop hybrid machine learning technique that is, capsule learning based neural network which categorize the attack in cloud environment. Finally, the proposed ST‐IDS technique can evaluate through standard open source datasets are KDD cup'99 and NSL‐KDD. The performance comparison of the proposed ST‐IDS technique using existing innovative technologies in terms of accuracy, precession, recall, specificity, F measure, false positive rate, and false negative rate.
Vertebrae localization and spine segmentation on radiographic images for feature‐based curvature classification for scoliosis
Authors: Fatima Joddat , Mohsan Mashood , Jameel Amina , Akram Muhammad Usman , Muzaffar Syed Adeel 
Published: August 2022

SummarySpinal cord is the one of the most important organs in the central nervous system (CNS). It acts as the main processing hub which serves as the main passage line for information transfer from brain to the rest of the body. It supports the whole skeleton structure along with mobility, bending, turning, twisting and so forth. Several factors may result in the deformity of spine such as a major injury, fracture or a defect by birth. In this research, we have discussed two modules: one is for vertebrae localization and spine segmentation and the second one is for analysis of spine dis‐proportionality. A recent approach of YOLOv5 is used for the localization of vertebrae in combination with Mask RCNN for segmentation of spinal column. The combined results from both these modules are used for feature extraction which supports our classification‐based shape analysis module. The AASCE 2019 challenge dataset is used to evaluate the experimental results and the value of mAP achieved is 0.94 at 0.5 IOU threshold of YOLOv5 model. The proposed technique with novel feature set achieved an average classification accuracy of 94.69%.
Enabling green supply chain integration via green entrepreneurial orientation: Does environmental leadership matter?
Authors: Wang Gang , Feng Taiwen , Zhu Zhanguo , Jiang Yisa 
Published: August 2022

AbstractAlthough both scholars and practitioners have recognized the crucial role of green supply chain integration (GSCI), our understanding of how green entrepreneurial orientation (GEO) may affect GSCI is scarce. Based on stakeholder theory and upper echelons theory, we examine whether GEO affects GSCI via environmental corporate strategy, and the moderating role of environmental leadership. We test the research hypotheses using multi‐sourced survey data from 264 Chinese firms. The results reveal that environmental corporate strategy partially mediates the impacts of GEO on green internal and external integration. Moreover, environmental leadership reinforces the impact of GEO on environmental corporate strategy while lessens the impact of environmental corporate strategy on green internal integration. However, the moderating effect of environmental leadership on the relationship between environmental corporate strategy and green external integration is not significant. This article provides theoretical contributions and managerial implications for the research on green entrepreneurship and GSCI.
Pituicytoma with pleomorphism: A case report with cytological findings
Authors: Shimizu Ayako , Nonami Yuji , Kanamuro Toshiko , Masui Kenta , Yamamoto Tomoko , Amano Kosaku , Kawamata Takakazu , Ichihara Atsuhiro , Nagashima Yoji 
Published: August 2022

AbstractPituicytoma is a rare neoplasm, arising in the posterior pituitary or in the hypophyseal stalk, and its cytological findings have not yet been well‐described. We have experienced a case of pituicytoma, which was difficult to diagnose intraoperatively, because of its cellular pleomorphism. A tumor measuring 18 mm in maximum diameter was found at the sella turcica in a Japanese woman in her forties. Both intraoperative crush cytology and histology of the resected tumor showed pleomorphic spindle or round cells, including multinucleated cells. Tumor cells were positive for TTF‐1, S‐100 protein, and vimentin, partially positive for glial fibrillary acidic protein and epithelial membrane antigen, and negative for synaptophysin, hormones of the anterior pituitary gland, CD34, Olig2, PAX8, and napsin A. Ki‐67 labeling index was 2.0%. Tumors included in the differential diagnosis in general are pituitary adenoma, craniopharyngioma, germinoma, and metastatic tumor on the radiological standpoint, and pilocytic astrocytoma and meningioma on the cytological standpoint. However, our case was difficult to differentiate especially from high‐grade glioma only by morphology, and immunohistochemistry including TTF‐1 was helpful.
Large flowers can be short‐lived: Insights from a high Andean cactus
Authors: Cuartas‐Domínguez Marcela , Robles Valeria , Arroyo Mary T. K. 
Published: August 2022

AbstractLong‐lived and large flowers signify high floral maintenance costs. Species of arid/semiarid climates with large flowers are expected to have short flower life spans and pollination‐induced flower longevity in order to curb high floral water and other maintenance costs. We explored the context‐dependent large flower/short flower longevity hypothesis in Eriosyce curvispina (Cactaceae), a large‐flowered species of the semiarid central Chilean Andes. We determined breeding system, flower visitation rates, and open‐pollination fruit set and quantified floral water content. In a temperature‐controlled field manipulative experiment, we measured potential flower longevity and tested for the presence of pollination‐induced floral senescence. We measured the time span of the complete flower cycle defined as from when the flowers began to open to when they were totally closed, and the time span of fully open flowers defined as from when they were totally open until they began to close. The potential flower life span averaged 2.8 days (complete flower cycle) to 2.3 days (fully open flower). The complete flower cycle lasted 21.5 h, but flowers were fully open for only 10.1 h across days. Flower longevity in days was far shorter than reported for a large sample of species in the area. No evidence was found for pollination‐induced flower senescence as a complementary means for reducing floral maintenance costs. Eriosyce curvispina is self‐incompatible and abundantly pollinated by two megachilid bees. The level of pollen limitation (L = 0.36) was lower than the average reported for self‐incompatible angiosperms. Thus, the short flower life span in E. curvispina is not an impediment for high fruit set. Flowers contain >5 g of water of which >2 reside in >40 petaloid tepals. The amount of water is far higher than in another large‐flowered, non‐cactus species in the area, but only about 15% of that reported in the giant saguaro cactus which has larger flowers than E. curvispina.
Bioinspired NC Coated BM‐ZIF for Electrochemical Monitoring of Adrenaline from Blood and Pharmaceutical Samples
Authors: Shakeel Faria , Asad Muhammad , Zafar Farhan , Abdelwahab Adel A. , Akhtar(s) Naeem , Badaruddin Ahmad Hafiz , Shafiq Zahid , Shenashen Mohamed A. 
Published: August 2022

AbstractHerein, we have developed highly sensitive and selective non‐enzymatic bioinspired polydopamine derived nitrogen rich carbon (NC) coated bimetallic zeolitic imidazolate framework (BM‐ZIF) electrochemical sensor via simple hydrothermal approach for monitoring adrenaline (AD) from COVID‐19 quarantined person blood and pharmaceutical sample. The designed NC‐BM‐ZIF electrode shows excellent sensitive and selective performance towards AD monitoring with detection limit (LOD) of 0.01 nM and 0.1931 μA/nM/cm2 sensitivity over a wide linear range of 50–1625 nM. To the best of our knowledge, this is the first study of using of NC‐BM‐ZIF electrode for the electrochemical sensing of AD from quarantined person blood and pharmaceutical sample.
Electrocatalytic Behavior of Manganese and Cobalt Porphyrins Attached to Graphene Quantum Dots: Applied in the Oxidation of Hydrazine
Authors: Jokazi Mbulelo , Mpeta Lekhetho S. , Nyokong Tebello 
Published: August 2022

AbstractManganese and cobalt metalated 5, 10, 15‐tris(aminophenyl)‐20‐(4‐carboxyphenyl) porphyrins (ClMnTA3CPP and CoTA3CPP) were synthesized and attached to graphene quantum dots (GQDs) via π‐π interaction and electrostatic interaction. The electrochemical oxidation of hydrazine was performed via cyclic voltammetry and chronoamperometry. The CoTA3CPP showed good electrocatalytic activity towards the oxidation of hydrazine in terms of catalytic rate constants and limits of detection (LoD). ClMnTA3CPP showed lower overpotential 0.60 V. The introduction of GQDs improved the electrocatalytic ability when combined with CoTA3CPP and ClMnTA3CPP with the lowest LoD (0.0025 mM CoTA3CPP–GQDs) followed by ClMnTA3CPP–GQDs with 0.0033 mM.