bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Hölder Regularity of a Linear Stochastic Partial-Integro-Differential Equation with Memory
Authors: McKinley Scott A. , Nguyen Hung D. 
Published: February 2022

AbstractIn light of recent work on particles fluctuating in linear viscoelastic fluids, we study a linear stochastic partial-integro-differential equation with memory that is driven by a stationary noise on a bounded, smooth domain. Using the framework of generalized stationary solutions introduced in McKinley and Nguyen (SIAM J Math Anal 50(5):5119–5160, 2018), we provide conditions on the differential operator and the noise to obtain the existence as well as Hölder regularity of the stationary solutions for the concerned equation. As an application of the regularity results, we compare to analogous classical results for the stochastic heat equation. When the 1d stochastic heat equation is driven by white noise, solutions are continuous with space and time regularity that is Hölder$$(1/2-\epsilon )$$(1/2-ϵ)and$$(1/4-\epsilon )$$(1/4-ϵ)respectively. When driven by colored-in-space noise, solutions can have a range of regularity properties depending on the structure of the noise. Here, we show that the particular form of colored-in-time memory that arises in viscoelastic diffusion applications, satisfying what is called the Fluctuation–Dissipation relationship, yields sample paths that are Hölder$$(1/2-\epsilon )$$(1/2-ϵ)and$$(1/2-\epsilon )$$(1/2-ϵ)in space and time.
Geometric design of friction ring dampers in blisks using nonlinear modal analysis and Kriging surrogate model
Authors: Sun Yekai , Denimal Enora , Yuan Jie , Salles Loïc 
Published: February 2022

AbstractIntegrally bladed disks (blisk) have been widely used in the turbo-machinery industry due to its high aerodynamic performance and structural efficiency. A friction ring damper (FRD) is usually integrated in the system to improve its low damping. However, the design of the geometry of this FRD become complex and computationally expensive due to the strong nonlinearities from friction interfaces. In this work, we propose an efficient modelling strategy based on advanced nonlinear modal analysis and Kriging surrogate models to design and optimize the geometry of a 3D FRD attached to a high fidelity full-scale blisk. The 3D ring damper is parametrised with a few key geometrical parameters. The impact of each geometric parameter and their sensitivities to nonlinear dynamic response can be efficiently assessed using Kriging meta-modelling based on a few damped nonlinear normal modes. Results demonstrate that the damping performances of ring dampers can be substantially optimized through the proposed modelling strategy whilst key insights for the design of the rings are given. It is also demonstrated that the distribution of the contact normal load on the contact interfaces has a strong influence on the damping performances and can be effectively tuned via the upper surface geometry of the ring dampers.
A clinical scoring tool validated with machine learning for predicting severe hand–foot syndrome from sorafenib in hepatocellular carcinoma
Authors: Abuhelwa Ahmad Y. , Badaoui Sarah , Yuen Hoi-Yee , McKinnon Ross A. , Ruanglertboon Warit , Shankaran Kiran , Tuteja Anniepreet , Sorich Michael J. , Hopkins Ashley M. 
Published: February 2022

Abstract
Purpose
Sorafenib is an effective therapy for advanced hepatocellular carcinoma (HCC). Hand–foot syndrome (HFS) is a serious adverse effect associated with sorafenib therapy. This study aimed to develop an updated clinical prediction tool that allows personalized prediction of HFS following sorafenib initiation.

Methods
Individual participant data from Phase III clinical trial NCT00699374 were used in Cox proportional hazard analysis of the association between pre-treatment clinicopathological data and grade ≥ 3 HFS occurring within the first 365 days of sorafenib treatment for advanced HCC. Multivariable prediction models were developed using stepwise forward inclusion and backward deletion and internally validated using a random forest machine learning approach.

Results
Of 542 patients, 116 (21%) experienced grades ≥ 3 HFS. The prediction tool was optimally defined by sex (male vs female), haemoglobin (< 130 vs ≥ 130 g/L) and bilirubin (< 10 vs 10–20 vs ≥ 20 µmol/L). The prediction tool was able to discriminate subgroups with significantly different risks of grade ≥ 3 HFS (P ≤ 0.001). The high (score = 3 +)-, intermediate (score = 2)- and low (score = 0–1)-risk subgroups had 40%, 27% and 14% probability of developing grade ≥ 3 HFS within the first 365 days of sorafenib treatment, respectively.

Conclusion
A clinical prediction tool defined by female sex, high haemoglobin and low bilirubin had high discrimination for predicting HFS risk. The tool may enable improved evaluation of personalized risks of HFS for patients with advanced HCC initiating sorafenib.
Minifragment plating of the fibula in unstable ankle fractures
Authors: Penning D. , Jonker C. A. L. , Buijsman R. , Halm J. A. , Schepers T. 
Published: February 2022

Abstract
Introduction
Only 6.4–17% of the load is transmitted through the fibula when weight-bearing. Plate fixation of distal fibular fractures using minifragments (≤ 2.8 mm) could lead to similar reduction with less implant removal (IR) rates, compared to small-fragment plates (3.5 mm). We hypothesized that the use of minifragment plates is at least similar in unscheduled secondary surgery.

Materials and methods
In this retrospective cohort study, all patients with surgically treated distal fibular fractures between October 2015 and March 2021 were included. Patients treated with plate fixation using minifragments and patients treated with small-fragment plates were compared regarding the following outcomes: secondary dislocation, malreduction, implant malposition, nonunion, surgical site infections (SSI) and IR.

Results
Sixty-five patients (54.2%) received a minifragment implant (≤ 2.8 mm) and 55 patients (45.8%) received a small-fragment implant (3.5 mm). There were no patients needing secondary surgery in the minifragment group compared to 9 patients following fixation using small-fragment implants (3 with secondary dislocation, 5 with malreduction and 1 with malposition, p = 0.001). SSI rates were 3.1% for minifragment and 9.1% for small-fragment implants (p = 0.161). Implant removal was performed significantly less often following use of minifragment implants (17.8% and 53.2%, p < 0.001).

Conclusions
In this cohort, minifragment plate fixation for distal fibular fractures is an adequate fixation method offering stable fixation with significant lower need for implant removal and comparable complications to small-fragment plates, although an adequately powered randomized controlled study is needed for implementation in a clinical setting.

Level of evidence
Therapeutic, III.
Tissue levels of suppressor of cytokine signaling-3 (SOCS-3) in mycosis fungoides
Authors: Nada Hanan R. , Rashed Laila A. , Salman Ola Ouda , Abdallah Nermeen M. A. , Abdelhady Mohamed M. 
Published: February 2022

AbstractMycosis fungoides (MF) is a type of cutaneous T-cell lymphoma with proposed multifactorial etiology. Suppressor of cytokine signaling-3 (SOCS-3) is one of the proteins expressed in MF. Its exact role in disease pathogenesis has not yet been thoroughly investigated. This study aimed to assess the expression of SOCS-3 in patients’ skin with mycosis fungoides to elucidate their possible role in the pathogenesis in MF. 30 patients with mycosis fungoides and 30 age and sex-matched healthy controls were included. After clinical examination, tissue levels of SOCS-3 were measured by ELISA. The level of expression of SOCS-3 was significantly upregulated in the lesional tissue compared to perilesional SOCS-3 level in patients’ group (P < 0.001), and both levels were higher than the SOCS-3 level in control group (P < 0.001). In addition, there was a statistically significant positive correlation between lesional SOCS-3 level and itching in patients’ group (P < 0.001). Regarding lesional and perilesional SOCS-3 levels in each stage, there was a significant increase in lesional SOCS-3 levels in comparison to perilesional level whether in stage Ia, Ib, and IIa; (P < 0.001), (P < 0.001) and (P < 0.001), respectively. Increased tissue levels of SOCS-3 patients with mycosis fungoides point to a role that SOCS-3 could play in its pathogenesis. Also, high levels of SOCS-3 in MF patients with itching suggest a role in the pathogenesis of this symptom. These findings may prove helpful in formulating a new treatment modality in addition to the current treatment of MF.
Outcome and management in neonates with gastroschisis in the third millennium—a single-centre observational study
Authors: Räsänen Lotta , Lilja Helene Engstrand 
Published: February 2022

AbstractGastroschisis is one of the most common congenital malformations in paediatric surgery. However, there is no consensus regarding the optimal management. The aims of this study were to investigate the management and outcome and to identify predictors of outcome in gastroschisis. A retrospective observational study of neonates with gastroschisis born between 1999 and 2020 was undertaken. Data was extracted from the medical records and Cox regression analysis was used to identify predictors of outcome measured by length of hospital stay (LOS) and duration of parenteral nutrition (PN). In total, 114 patients were included. Caesarean section was performed in 105 (92.1%) at a median gestational age (GA) of 36 weeks (range 29–38) whereof (46) 43.8% were urgent. Primary closure was achieved in 82% of the neonates. Overall survival was 98.2%. One of the deaths was caused by abdominal compartment syndrome and one patient with intestinal failure–associated liver disease died from sepsis. None of the deceased patients was born after 2005. Median time on mechanical ventilation was 22 h. Low GA, staged closure, intestinal atresia, and sepsis were independent predictors of longer LOS and duration on PN. In addition, male sex was an independent predictor of longer LOS.Conclusion: Management of gastroschisis according to our protocol was successful with a high survival rate, no deaths in neonates born after 2005, and favourable results in LOS, duration on PN, and time on mechanical ventilation compared to other reports. Multicentre registry with long-term follow-up is required to establish the best management of gastroschisis.

What is Known:• Gastroschisis is one of the most common congenital malformations in paediatric surgery with increasing incidence.• There is no consensus among clinicians regarding the optimal management of gastroschisis.

What is New:• Although primary closure was achieved in 82% of the patients, mortality rate was very low (1.8%) with no deaths in neonates born after 2005 following the introduction of measurement of intraabdominal pressure at closure.• Low gestational age, staged closure, intestinal atresia, sepsis, and male sex were independent predictors of longer length of hospital stay.
Current Research on Theory and Practice of Digital Libraries: Best Papers from TPDL 2019 & 2020
Authors: Aalberg Trond , Duchateau Fabien , Hall Mark , Merc̆un Tanja , Risse Thomas 
Published: February 2022

AbstractThis volume presents a special issue on selected papers from the 2019 & 2020 editions of the International Conference on Theory and Practice of Digital Libraries (TPDL). They cover different research areas within Digital Libraries, from Ontology and Linked Data to quality in Web Archives and Topic Detection. We first provide a brief overview of both TPDL editions, and we introduce the selected papers.
Planfeststellung und Plangenehmigung im Wasserhaushaltsrecht
Authors: Kümper Boas 
Published: February 2022

ZusammenfassungPlanfeststellung und Plangenehmigung sind etablierte Instrumente der Vorhabenzulassung und für
den Gewässerausbau bereits seit langem auch im Wasserhaushaltsrecht vorgesehen, nehmen dort aber eine
Sonderstellung ein, weil sie aufgrund der Vielfältigkeit der als Gewässerausbau zu qualifizierenden
Vorhaben teilweise eine andere Funktion haben als in den Materien der klassischen Infrastrukturplanung.
Sie haben dementsprechend im WHG eine spezifische gesetzliche Regelung erfahren. Die Besonderheiten resultieren
vor allem aus der in diesem Beitrag erörterten Reichweite des wasserhaushaltsrechtlichen Planfeststellungsvorbehalts
und kommen zudem in der wasserhaushaltsrechtlichen Ausformung alternativer Verfahrensgestaltungen –
der Plangenehmigung sowie der Freistellung von der Planfeststellungspflicht – zum Ausdruck.
A Canadian national guideline on the neoadjuvant treatment of invasive breast cancer, including patient assessment, systemic therapy, and local management principles
Authors: Gandhi Sonal , Brackstone Muriel , Hong Nicole J. Look , Grenier Debjani , Donovan Elysia , Lu Fang-I. , Skarpathiotakis Mia , Lee Justin , Boileau Jean-Francois , Perera Francisco , Simmons Christine , Joy Anil A. , Tran William T. ,   The Canadian National Neoadjuvant Breast Cancer Consortium, Tyono Ivan , Van Massop Althea , Khalfan Shelyna 
Published: February 2022

Abstract
Purpose
The neoadjuvant treatment of breast cancer (NABC) is a rapidly changing area that benefits from guidelines integrating evidence with expert consensus to help direct practice. This can optimize patient outcomes by ensuring the appropriate use of evolving neoadjuvant principles.

Methods
An expert panel formulated evidence-based practice recommendations spanning the entire neoadjuvant breast cancer treatment journey. These were sent for practice-based consensus across Canada using the modified Delphi methodology, through a secure online survey. Final recommendations were graded using the GRADE criteria for guidelines. The evidence was reviewed over the course of guideline development to ensure recommendations remained aligned with current relevant data.

Results
Response rate to the online survey was almost 30%; representation was achieved from various medical specialties from both community and academic centres in various Canadian provinces. Two rounds of consensus were required to achieve 80% or higher consensus on 59 final statements. Five additional statements were added to reflect updated evidence but not sent for consensus.

Conclusions
Key highlights of this comprehensive Canadian guideline on NABC include the use of neoadjuvant therapy for early stage triple negative and HER2 positive breast cancer, with subsequent adjuvant treatments for patients with residual disease. The use of molecular signatures, other targeted adjuvant therapies, and optimal response-based local regional management remain actively evolving areas. Many statements had evolving or limited data but still achieved high consensus, demonstrating the utility of such a guideline in helping to unify practice while further evidence evolves in this important area of breast cancer management.
Sexual activity and functioning in long-term breast cancer survivors; exploring associated factors in a nationwide survey
Authors: Smedsland Solveig K. , Vandraas Kathrine F. , Bøhn Synne K. , Dahl Alv A. , Kiserud Cecilie E. , Brekke Mette , Falk Ragnhild S. , Reinertsen Kristin V. 
Published: February 2022

Abstract
Purpose
Sexual health is a key quality of life issue. Knowledge concerning sexual health in long-term breast cancer survivors (BCSs) is limited. Within a nationwide sample, we aimed to assess the prevalence of sexual inactivity and to explore factors associated with sexual inactivity and reduced sexual functioning among long-term BCSs.

Methods
Long-term BCSs aged 20–65 years when diagnosed with early-stage breast cancer in 2011–2012 were identified by the Cancer Registry of Norway in 2019 (n = 2803) and invited to participate in a nationwide survey. Sexual health was measured using the multidimensional Sexual Activity Questionnaire. Factors associated with sexual inactivity and reduced sexual functioning were explored using multivariable logistic- and linear regression analyses with adjustments for relevant sociodemographic, health-, and cancer-related variables.

Results
The final sample consisted of 1307 BCSs with a mean age of 52 years at diagnosis. Fifty-two percent of the BCSs were sexually inactive. Lack of interest was the most common reason for sexual inactivity. Treatment with aromatase inhibitor (OR 1.73, 95% CI 1.23, 2.43) and poor body image (OR 0.99, 95% CI 0.99, 0.995) were associated with sexual inactivity. Among sexually active BCSs, depression (B − 1.04, 95% CI − 2.10, − 0.02) and physical inactivity (B − 0.61, 95% CI − 1.21, − 0.02) were inversely related to sexual pleasure. Treatment with aromatase inhibitor (B 0.61, 95% CI 0.20, 1.01), sleep problems (B 0.37, 95% CI 0.04, 0.70), breast symptoms (B 0.01, 95% CI 0.003, 0.02), and chronic fatigue (B 0.43, 95% CI 0.05, 0.81) were associated with sexual discomfort. Chemotherapy (OR 1.91, 95% CI 1.23, 2.97), current endocrine treatment (OR 1.98, 95% CI 1.21, 3.25), and poor body image (OR 0.98, 95% CI 0.98, 0.99) were associated with less sexual activity at present compared to before breast cancer.

Conclusion
Treatment with aromatase inhibitor seems to affect sexual health even beyond discontinuation. Several common late effects were associated with sexual inactivity and reduced sexual functioning. To identify BCSs at risk of sexual dysfunction, special attention should be paid to patients treated with aromatase inhibitor or suffering from these late effects.
Multiscale evaluation of CMIP5 models using wavelet-based descriptive and diagnostic techniques
Authors: Gallegati Marco 
Published: February 2022

AbstractTime–frequency localization of model-data discrepancies may provide useful information for climate models inter-comparison, and especially for the goals of climate model refinement and improvement. CMIP5 models of the long-term historical (1850–2005) run experiment are compared using wavelet-based multiscale descriptive and diagnostic techniques with interesting results. Wavelet coherence maps can visualize the ability of alternative CMPI5 models to capture the observed climate variability at different time scales, while the performance of each CMIP5 model is assessed using goodness of fit relative measures on a scale-by-scale basis. Finally, the plots of wavelet decompositions of CMIP5 models and observed temperature series at different scales can detect and locate model/data disagreements across frequencies and over time, thus providing useful information to researchers for model diagnostic refinement and improvement.
Reading a Duty to Provide Accessible Pre-Contractual Information for Consumers with Disabilities into EU Consumer Protection Law
Authors: Waddington L. 
Published: February 2022

AbstractThis paper considers whether a duty to provide consumers with disabilities with pre-contractual information in an accessible format, or in an otherwise personalised format, can be read into EU consumer protection law. Such a duty could be regarded as a particular form of reasonable accommodation. The paper explores this issue in the context of three key consumer protection instruments: the Unfair Commercial Practices Directive, the Consumer Credit Directive, and the Consumer Rights Directive. The paper argues that the Directives should be interpreted in light of the EU’s obligations under the UN Convention on the Rights of Persons with Disabilities (CRPD) which addresses,inter alia, the accessibility of information. Whilst consumer protection is an area of shared competence between the EU and its Member States, the three Directives examined in the paper largely provide for “full harmonisation,” thereby limiting the scope Member States have for taking action in these fields. In light of this, the paper argues that the EU has, to a large degree, taken on responsibility for complying with the CRPD in these fields, and that the Directives should be interpreted in light of those obligations. The EU Charter of Fundamental Rights can further bolster a human rights compatible interpretation of EU consumer protection directives. The paper also considers the extent to which the Directives allow Member States some residual competences to set requirements concerning pre-contractual information for persons with disabilities. To the extent that such competences exist, the paper argues that CRPD-compatible minimum requirements for pre-contractual information provided to consumers with disabilities should be read into the Directives by the European Court of Justice. Establishing CRPD-compatible minimum requirements in this field would reduce the need for individual Member States to take action to comply with the CRPD, and therefore reduce the risk of divergent national standards which could undermine the internal market goals of the relevant Directives. The paper concludes that a duty to provide a de facto reasonable accommodation, in terms of accessible and additional information, can be read into the Consumer Credit Directive and the Consumer Rights Directive. A more limited duty, concerning only the provision of additional information for persons with disabilities, can be read into the Unfair Commercial Practices Directive. It is unclear whether case law of the Court of Justice can be interpreted as requiring the provision of accessible information under this last Directive.
Reducing carbon emissions in Egyptian roads through improving the streets quality
Authors: Moussa Rania Rushdy 
Published: February 2022

AbstractThe streetscape of any city reflects the natural built fabric of the street and adds to the experiential quality of that space. A sustainable streetscape ensures that the spaces are long-lasting and functional as a part of the greater sustainable eco-system. Over the past two centuries, mankind has increased the concentration of carbon dioxide (CO2) in the atmosphere from 280 to more than 380 parts per million by volume, and it is still increasing every day. If Earth continues to emit carbon without control, the surface temperature is expected to rise by 3.4 °C by the end of this century. Climate change of that magnitude would likely have serious, long-lasting, and, in many cases, devastating consequences for the planet Earth. Egypt has become one of the biggest emitters of atmospheric pollutants from the transportation sector. The level of carbon emissions and its effect on air quality are placed high on the research agenda. The transportation sector has a great impact on increasing CO2 emissions. The transportation and traffic sectors produce a quarter of the global CO2 emissions due to the heavy use of fossil fuels. This research aims to study the effects of street shape and design on CO2 production. This paper presents an analysis of road transportation in Egypt, taking Helmiet EL-Zaitoun as the main case study, with a focus on energy demand and carbon dioxide (CO2) emissions. Carbon emissions are measured using “Testo 315-3” as a measuring instrument to identify the relationship between street design and quality on the amount of carbon emissions produced. The results of this research suggest that street quality affects the amount of CO2 emissions produced. A car moving at a constant speed will produce fewer CO2 emissions than a car forced to start–stop every while because of external factors such as cracks in the roads occurring from bad streetscape elements. The presented research provides a set of guidelines to enhance the quality of the streetscape and design in order to reduce the amount of CO2 produced in the streets.