bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bronquiolitis aguda: hospitalización, complicaciones y manejo terapéutico en menores de dos años atendidos en un centro de referencia en 2017 y 2018. Estudio descriptivo
Authors: Jaramillo-Cerezo Andrea , Cardona Laura Valentina , Arango Olga Isabel , Tamayo-González Nathalia Andrea , Rodriguez-Padilla Libia María , Parra-Buitrago Andrea 
Published: August 2022

Introducción: la bronquiolitis aguda se define como el primer episodio bronco-obstructivo en menores de dos años, precedida por signos de infección de las vías aéreas superiores. Su importancia radica en la alta prevalencia de la enfermedad, puesto que en Colombia es la primera causa de hospitalización en menores de un año. Si bien es una enfermedad con baja letalidad, hay grupos de pacientes que pueden desarrollar complicaciones graves.
Objetivo: describir la frecuencia de hospitalización y complicaciones, así como el manejo terapéutico de menores de dos años con bronquiolitis aguda en una institución de alta complejidad.
Métodos: se hizo un estudio observacional descriptivo retrospectivo. La población estudiada estuvo compuesta por lactantes con diagnóstico de bronquiolitis que ingresaron a la institución durante el 2017 y 2018. La información fue consignada en una base de datos y analizada utilizando el programa SPSS-24.0.
Resultados: se incluyeron 427 pacientes, de los cuales 266 eran mujeres (62,3 %); la mediana de edad fue de 2 meses (1-5 meses). Las retracciones estuvieron presentes en 242 de los lactantes (56,7 %). Requirieron hospitalización 268 (62,8 %), con una mediana de estancia de 4 días (2-7 días). Entre los hospitalizados, 32 (11,9 %) fueron ingresados a UCIP. El lavado nasal fue la terapia más usada, aplicada a 365 pacientes (85,5,1 %). A 259 (60,6 %) se les realizó panel viral, donde el VRS fue el principal agente encontrado.
Conclusiones: aunque más de la mitad de los pacientes requirieron hospitalización, la mayoría tuvo un curso benigno. Si bien el manejo fue diverso, el sintomático fue el predominante.
El reto diagnóstico de la enfermedad de Cushing en pediatría: reporte de casos
Authors: Medina-Paternina Olga , Villa-Delgado Rosmery , García-Bermejo Roberto 
Published: August 2022

Introducción: la enfermedad de Cushing (EC) se debe sospechar en el paciente pediátrico con retraso del crecimiento, aumento de peso y fenotipo característico. Se sugiere iniciar el protocolo diagnóstico, que consiste en: comprobación de hipercortisolemia, sitio de producción del cortisol e imágenes, para finalmente realizar el tratamiento quirúrgico curativo.
Reporte de casos: se presentan los casos de tres pacientes con alteración de la velocidad de crecimiento, aumento de peso y fenotipo característico. Se realiza la secuencia diagnóstica para demostrar el hipercortisolismo, posteriormente se confirma EC y se realiza imagen por resonancia magnética nuclear (RMN) de hipófisis. Finalmente se lleva a cabo el tratamiento quirúrgico curativo.
Conclusiones: la EC en pediatría sigue siendo un desafío diagnóstico. Un abordaje para su detección inicia con la sospecha clínica asociada a una adecuada interpretación de los estudios bioquímicos e imágenes, lo que permite realizar un diagnóstico oportuno y un tratamiento curativo definitivo.
English For Chemistry Book As A Learning Resource In University
Authors: Oktapianti Siska 
Published: August 2022

This study is a specified inspection of the development of the chemistry educational sources. The purposes of this study are: (1) to develop a book “English for Chemistry”, (2) to assess the quality of the book based on appraisement of lecturers and students. The type of the research is R & D. There many stages carried out in this investigation developed by Borg & Gall. The instrument used to assess the quality of this book is a set of quality having some aspects and criteria. The evaluations included 6 aspects with 33 criteria for lecturers and 4 aspects with 25 criteria for students. The evaluation result is in qualitative data and then the result is analyzed by the ideal evaluation criteria category guide to determine the quality of the book. Based on lecturers’ assessments, the book has a good quality, going to the score of 116 out of 165 and ideal percentage 70.3%. Meanwhile, in students’ side, the book is also classified as a good quality, whose score is 103 out of 125 and ideal percentage 82.4%. Development english for chemistry book, helping student understand scientific words of chemistry in english.
Thrombosis Mechanisms in Obese and Ischemic Stroke COVID-19 Patients: A Literature Review
Authors: Winanda Putri , Putri Natasya 
Published: August 2022

Highlight:

The ongoing Coronavirus disease 2019 also affects multiorgan, including cardiovascular disease with several factors.
Mechanism of thrombus in the patient that induces the subject such as obesity with increased BMI, thrombotic pathway modulator and pathophysiologist.
An increase in acute CVD incidence, including ischemic stroke in COVID-19 patients, has been a new concern in the ongoing pandemic.

ABSTRACT
Coronavirus disease 2019 (COVID-19), despite being a respiratory infection, also causes neurological manifestations such as stroke due to thrombosis formation. Prior investigations have examined the correlation between COVID-19 and ischemic stroke, as well as COVID-19 and obesity. However, the mechanism of thrombosis in obese COVID-19 patients remains elusive. This review aims to examine the mechanism of thrombosis in COVID-19 patients with ischemic stroke and obesity. Chronic inflammation and impaired fibrinolysis are two major pathways responsible for thrombosis in people with obesity. Chronic inflammation activates prothrombic signaling pathways in vascular cells, resulting in procoagulant factors and adhesion molecules upregulation, anticoagulant proteins downregulation, platelet activation enhancement, and increased thrombin generation. SARS-CoV-2 enters human cells utilizing the angiotensin-converting enzyme 2 (ACE-2) receptors, which results in inflammation, which has been suggested as one of the factors contributing to thrombotic complications in COVID-19 patients. The infection also causes cytokine storm that induces atherosclerosis, plaque rupture, and superimposed thrombosis leading to brain damage. Together with endothelial injury, the cytokine storm might increase the expression of tissue factors and further promote a prothrombic state. In conclusion, the mechanisms of thrombosis in COVID-19 patients are related to direct infection of SARS-CoV-2 into the ACE-2 receptor and the cytokine storm that results in chronic inflammation and thrombosis formation. Obesity will further boost the inflammation process that leads to the formation of thrombosis and increase the risk of ischemic stroke among individuals with COVID-19 with obesity.
PENGEMBANGAN MODUL PEMBUATAN TES ASESMEN KOMPETENSI MINIMUM PADA PLATFORM E-LEARNING BERBASIS MOODLE UNTUK GURU SEKOLAH
Authors: Mutoharoh M , Muliyati Dewi , Simanjuntak Bintang Ronauli 
Published: August 2022

One of the objectives of implementing the Minimum Competency Assessment (AKM) is to show how to master the essential competencies needed in various subjects. At the same time, digital formats must be integrated at every level of education, including the assessment process. Responding to the latest regulations regarding assessment and advances in digital technology requires teachers to have a combination of content and support skills. This study aims to develop an integrated media and environment for in-service teachers to improve their skills in creating AKM tests. The resulting test is designed according to variations in Moodle-based e-learning. This platform was chosen because many schools use Moodle as a Learning Management System (LMS). The study was conducted using the research and development method of the Thiagarajan 4D model, with the steps of define, design, develop, and disseminate. The development results include products, skills improvement, and a portfolio of user implementation results.
Preperitoneal Pelvic Packing for Hypotension Has a Greater Risk of Venous Thromboembolism Than Angioembolization
Authors: Patterson Joseph T. , Wier Julian , Gary Joshua L. 
Published: August 2022

Background:
Patients with traumatic pelvic ring injury may present with hypotension secondary to hemorrhage. Preperitoneal pelvic packing (PPP) and angioembolization (AE) are alternative interventions for management of hypotension associated with pelvic ring injury refractory to resuscitation and circumferential compression. We hypothesized that PPP may be independently associated with increased risk of venous thromboembolism (VTE) compared with AE in patients with hypotension and pelvic ring injury.

Methods:
Adult patients with pelvic ring injury and hypotension managed with PPP or AE were retrospectively identified in the Trauma Quality Improvement Program (TQIP) database from 2015 to 2019. Patients were matched on a propensity score for receiving PPP based on patient, injury, and treatment factors. The primary outcome was the risk of VTE after matching on the propensity score for treatment. The secondary outcomes included inpatient clinically important deep vein thrombosis, pulmonary embolism, respiratory failure, mortality, unplanned reoperation, sepsis, surgical site infection, hospital length of stay, and intensive care unit (ICU) length of stay.

Results:
In this study, 502 patients treated with PPP and 2,439 patients treated with AE met inclusion criteria. After propensity score matching on age, smoking status, Injury Severity Score, Tile B or C pelvic ring injury, bilateral femoral fracture, serious head injury, units of plasma and platelets given within 4 hours of admission, laparotomy, and level-I trauma center facility designation, 183 patients treated with PPP and 183 patients treated with AE remained. PPP, compared with AE, was associated with a 9.8% greater absolute risk of VTE, 6.5% greater risk of clinically important deep vein thrombosis, and 4.9% greater risk of respiratory failure after propensity score matching.

Conclusions:
PPP for the management of hypotension associated with pelvic ring injury is associated with higher rates of inpatient VTE events and sequelae compared with AE.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Competent and Employed: STEM alumni perspectives on undergraduate research and NACE career-readiness competencies
Authors: Newell Mi'Kayla , Ulrich Paul 
Published: August 2022

There have been large increases in the number of STEM graduates in the United States, but the majority of growth in non-healthcare, career opportunities are limited to computer specialists and engineering. Thus, two challenges await STEM students upon graduation: strong competition and employer concerns that applicants lack general competencies and work experience. Universities have responded to employer concerns with initiatives to enhance career readiness by embedding sets of competencies throughout curricula. However, these competencies have not been situated in STEM contexts and are derived largely from surveys of representatives from large companies who are unfamiliar with the job requirements specific to STEM positions. The current study uses a mixed methods approach as a first step to investigate the National Association of Colleges and Employers Career-Readiness Competencies in STEM with alumni who have participated in UREs and are currently employed in STEM careers. We propose that institutions can simultaneously situate skill development in STEM and provide meaningful, work-like experience through undergraduate research experiences (UREs). Findings demonstrate that UREs provide a fertile ground for the integration of career related competencies into undergraduate curricula and suggest institutions should strategically implement career-readiness competencies that reflect the priorities of STEM employers.
Keywords: STEM, career readiness, NACE competencies, alumni, undergraduate research experiences, employment
Easy Life with Automated Digitalised Analytic Tools for Well Integrity Management for Unstructured Brown Field
Authors: Wejwittayaklung Kittipat , Nadoon Apiwat , Hnuruang Kittithuch , Pirom Pavin , Promwikorn Potchara , Jirajindakul Prasert , Chandakaew Rossawan , Singsa-Nga Supoth , Kunpitaktakun Takonpran , Toempromraj Wararit , Yokrat Yaovanart , Konganuntragul Pornchuda 
Published: August 2022

Abstract
To ensure all wells are in good and safe condition and can be operated as designed, the well integrity of individual wells must be maintained. However, lack of utilization and analysis of the well integrity status in brownfields with lots of qualitative data, the different well integrity standards, especially in newly acquired assets with unconsolidated well integrity database, and limited resources. The Well Integrity Management project was then proposed, and the Visualization Management Platform (VMP) was created.
The VMP will centralize the well integrity database for all operating assets, develop a "Well Failure Model" for better classification of well integrity problems with the right actions to be taken, and develop a visualization of well integrity status using the business intelligent application in Power BI, for mapping well integrity status with other critical related key information i.e. production performance, remaining reserves, and integrity records. It will automatically generate a work plan based on the priority to be executed, well location distance, and weather forecast, automatically generate a work program to reduce the engineer's task, and automatically send an alert notification to the related person to prevent overdue tracking.
More than 3,000 wells have been effectively monitored and managed thru this platform with limited resources. The VMP defines and provides the operating standards and guidelines to maintain well integrity, ensuring safe well operations. The system can provide real-time monitoring for better planning and minimizing backlog, better decision making on well utilization management, set the priority for well maintenance, and create an efficient Workplan for well services working team, as well as minimize routine tasks for an engineer in issuing well integrity work program. Moreover, the system will send an auto alert to the responsible person when there is any issue about well integrity to reduce work process cycle time which will reduce the potential risks to well equipment and personnel. The system is also useful for plug and abandonment when wells have come to the end of their lives because it contains information about the history well activities and current well status. Not only do the existing operating asset get benefits from this platform but also the management and the asset team.
Digital technologies were used for real-time extracting information from several types of data formats, integrating it into the data lake in Google Cloud Platform, and demonstrating in the Business intelligent tools. This was the showcase to apply the digital tools supporting the brown field's well integrity management to improve the well assurance and make your wells safe for everyday operations.
Understanding Thermo-Poroelastic Mechanical Stress Induced Damages in Network of Pre-Existing Fractures During Drilling Operation
Authors: Gomar Mostafa , Elahifar Behzad 
Published: August 2022

Abstract
In drilling the reservoir sections of a well, one of the most challenging issues is reducing damage to the reservoir by controlling downhole pressure. Many drilling techniques such as underbalanced drilling (UBD) and managed pressure drilling (MPD) are employed to minimize the risks associated with drilling as well as to minimize damage to the porous rock. Even though chemical and physical damages may be short-term and could be repaired by some stimulation techniques, the long-term effects of mechanical damages in porous and fractured reservoirs have received insufficient attention. Accordingly, not only could the above drilling techniques be applied to solve downhole drilling problems, but they also may be used to reduce induced mechanical damages in fractured rocks.
This article presents a new method for modeling changes in fracture permeability caused by drilling in fractured rocks. As part of the approach, the finite element method (FEM) is employed to conduct a thermo-poroelastic analysis of stress distributions around the borehole and the displacement discontinuity method (DDM) is used to model fracture deformations. Based on different fracture spacings and fracture inclination angles, we have considered models of regular fracture networks in the present study. This study focuses on the differences in permeability in underbalanced and overbalanced drilling operations that are compared together in different models.
Effective stress differences (over 40 MPa) were found along and around borehole periphery. Shear stresses in the oblique fracture network also governed aperture change. Short-term mechanical stresses and long-term thermal and fluid pressures determine the fracture aperture. In the long run, fluid pressure and thermal stresses contribute to long term permeability change of fractures while mechanical stresses cause a short-term change. Underbalanced drilling was simulated to reduce fracture permeability, while cooling and pressurizing of rock encouraged fracture permeability without considering solid particle plugging. Fracture aperture adopts a seesaw pattern in a small-spaced fracture network. When the fracture aperture increases in a fracture, the neighboring fractures experience decreased apertures. Despite the drilling method, fractures intersecting boreholes have reduced permeability after drilling for a long time, as they choked in a few locations along the fracture length.
At present, the industry considers managed pressure and underbalanced drilling to be the priority for resolving drilling problems. This paper investigates stress-induced damages in fractured rocks under overbalanced and underbalanced drilling conditions. It is also of significant interest in geothermal reservoirs, where the temperature difference between the rock and the well bore fluid is large. Furthermore, such an analysis would provide the optimal well location from a geomechanical and reservoir engineering standpoint.
InSight: Corrosion-Wise Monitoring Tool Empowered by Robot Process Automation
Authors: Wejwittayaklung Kittipat , Piyakunkiat Nuttapon 
Published: August 2022

Abstract
InSight is the corrosion-wise monitoring tool that aims for facilitating the engineers in input data consolidation and corrosion analysis. By using the Robot Process Automation (RPA) digital tool and Business Intelligent (BI) tools, this time-consuming process will be dramatically expedited. Now, the project scope is only to analyze and monitor field integrity e.g., surface piping and downhole well tubing. However, it can be scaled up to other applications and business areas.
RPA on the engineering software requires detailed steps and layers of commands. Developing the new RPA engine is a more flexible and generic way to manipulate the engineering software. The well test data stored in the database was linked to the on-premises server in which the RPA engine and corrosion simulation were deployed and installed. After daily data arrived, the RPA will be automatically run and transfer the result of the corrosion analysis back into the database. BI tool then pulls the data from the database and visualizes the analysis result, also has an alarm function to responded parties.
InSight has been developed by PTTEP since 2020. RPA engine for two corrosion simulations was completely deployed namely PRECORR and OLI. Now running corrosion simulation is easy with just one click and over a thousand cases can be run within a day. Generally, this corrosion simulation via RPA is 9 times faster than the human. The engineers will then have more time to focus on data quality verification and the data analytics of the simulation result. The tool is quite flexible for the users. The data pulled from the daily database can be manually selected and corrected. In addition, a sensitivity analysis can be designed. Likewise, the result visualization can be customized. Subsequently, the actual field corrosion logging data or the laboratory corrosion tests can be tied in for the model calibration. Moreover, the tool can add more corrosion simulation software with additional effort. However, the main users are still improving the tool performance throughout the real use cases.
This RPA engine will change the world of routine corrosion simulation and monitoring. Also, it can be supplied to any routine engineering simulations. For this project, the well will be produced safely with close monitoring of corrosion and an alarm system.
Study on 4D Geomechanical Application in Fault Sealing Capacity Evaluation of Underground Gas Storage
Authors: Luo Yu , Li Longxin , Zhou Yuan , Li Limin , Zhao Yuchao , Wei Hua , Liu Qiyao , Liu Xiao , Huang Xingning , Singjaroen Thanapol 
Published: August 2022

Abstract
In order to ensure the national demand for peak shaving and supply guarantee, the project of Xiangguosi underground gas storage capacity expansion for target productivity has been proposed and being carried out. For the purpose of effectively guiding the optimization of the operation upper limit pressure of the gas storage and ensuring its long-term safe operation, it is urgently needed to carry out the assessment of the integrity of the cap rock of the gas storage and the stability of its faults. Based on geological, seismic, logging, dynamic monitoring data and core experimental data, this paper established static and dynamic geomechanical models of the gas storage and analyzed the characteristics of the in-situ stress of different layers of it to simulate and evaluate the stability of the cap rock, underpinning layer and faults of reservoir under different pore pressure. The results showed that 5 reservoir-controlling faults had no risk of fault activation in the early operation of the gas storage and the current stress conditions, with good sealing performance, and when the reservoir pressure was 6MPa higher than the original formation pressure, there was a risk of instability in the integrity of the gas storage. The research results finely and quantitatively evaluated the operation safety of the gas storage under the influence of the dynamic stress field, and had important guiding significance for the optimization of the operation plan of the gas storage.