bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolomic Profile in Adolescents with PCOS vs. Transgender Males on Testosterone
Authors: Nokoff Natalie Jessica , Lo Jaclyn S , Alexander Keisha , D’Alessandro Angelo , Severn Cameron , Staggs Syd , Zeitler Philip S , Cree-Green Melanie 
Published: June 2022

Abstract
Background: Although there are sex differences in metabolomic profiles, little is known about the effects of testosterone on the metabolomic profile of people with a female sex. We evaluated the effect of endogenous versus exogenous testosterone on the plasma metabolomic profile. Methods: Participants included 20 individuals with a female sex designated at birth. Ten transgender male (TGM) adolescents [age 15.5 + 0.9 years, BMI percentile 74% (32, 94)] were evaluated at baseline and after one month of exogenous testosterone treatment (TGM-1M). TGM-1M were compared to 10 BMI-matched cisgender female adolescents with polycystic ovary syndrome [PCOS, age 15.8 + 1.8 years, BMI 85% (78, 98)]. All participants had fasting laboratory evaluation and targeted fasting plasma metabolomic analysis. Results: There were no significant differences in metabolomics after 1 month of testosterone therapy in the TGM group. There were significant differences in the targeted metabolomic analysis between the adolescents with PCOS and TGM-1M. Eight bile acids, 5 fatty acids and 2 amino acids were higher in the PCOS group (fold change>2) compared to TGM-1M. Five amino acids, 2 acylcarnitines, and one fatty acid were higher in TGM-1M compared to participants with PCOS. Participants with PCOS had more signs of metabolic syndrome, including higher waist/hip ratio, systolic blood pressure, and dyslipidemia compared to TGM-1M.Conclusions: Long-term endogenous testosterone exposure in PCOS is associated with an altered metabolic profile and changes in bile acid and fatty acid metabolism relative to short-term exogenous exposure in TGM-1M, suggesting other features, besides testosterone are responsible for the metabolic features of PCOS.
Retrospective evaluation of satisfaction levels of completely edentulous patients treated with implant supported prosthesis
Authors: Demir Esin , ozel gulsum , inan özgür , dolanmaz dogan 
Published: June 2022

Abstract
Aim: The purpose of this study is to evaluate and compare patient satisfaction levels in edentulous patients treated with implant­ supported overdentures and/or implant supported fixed prostheses. Material and Methods: A study population of 98 patients was identified. Patients seperated into three treatment types. Group I comprised 36 patients treated with implant supported maxillomandibular fixed restorations while group II comprised 43 patients treated with implant supported overdentures. Group III comprised 19 patients treated implant supported overdenture for mandible and fixed prosthesis for maxilla. A questionnaire consisting of specific issues about masticatory performance, aesthetics and comfort were used to evaluate treatment outcomes. Results: The sample comprised 59 female and 39 male patients with a mean age of 67.6 years (range between 40 and 78). The patients in Group II were significantly less satisfied with masticatory function, comfort and social ability. No significant differences were found for satisfaction as compared to educational status and economic status. Conclusions: It was found that treatment design of that implant supported fixed prosthesis on maxilla and implant overdenture on mandible provided comparable level of satisfaction for edentulous patients. Implant supported fixed prosthesis for maxilla and implant supported overdenture for mandible serve practical alternative to satisfy patients especially in mandibular atrophy patients who would demand extensive surgeries.
Performance of several types of beta-binomial models in comparison to standard approaches for meta-analyses with very few studies
Authors: Felsch Moritz , Beckmann Lars , Bender Ralf , Kuss Oliver , Skipka Guido , Mathes Tim 
Published: June 2022

Abstract
BackgroundMeta-analyses are used to summarize the results of several studies to a specific research question. Standard methods for meta-analyses, namely inverse variance random effects models have unfavourable properties if only very few (2-4) studies are available. Therefore, alternative meta-analytic methods are needed. In case of binary data, the “common-rho” beta-binomial model has shown good results in situations with spare data or few studies. The major concern of this model is that it ignores the fact that each treatment arm is paired with a respective control arm from the same study. Thus, the randomisation to a study arm of a specific study is disrespected, which may lead to compromised estimates of the treatment effect. Therefore, we extended this model to a version that respects randomisation. The aim of this simulation study was to compare “common-rho” beta-binomial model and several other beta-binomial models to standard meta-analyses models including generalised linear mixed models and several inverse variance random effects models.MethodsWe conducted a simulation study in which beta-binomial models and various standard meta-analysis methods were compared. The design of the simulation aimed to consider meta-analytic situations occurring in practice. ResultsIn summary, no method performed well in scenarios with only 2 studies in the random effects scenario. In this situation, a fixed effect model or a qualitative summary of the study results may be preferable. In scenarios with 3 or 4 studies the “common-rho” beta-binomial model performed at least slightly better than other models, whereas performance was not improved by the beta-binomial model respecting randomisation. ConclusionThe “common-rho” beta-binomial appears to be a good option for meta-analyses of very few studies. Because residual concerns about the consequences of disrespecting the randomisation may still exist, we recommend a sensitivity analysis with a standard meta-analysis method that respects randomisation.
Assessing the performance of the satellite-based precipitation products (SPPs) in the data-sparse Himalayan terrain
Authors: Kumar Sonu , Amarnath Giriraj , Ghosh Surajit , Park Edward , Baghel Triambak , Jingyu Wang , Belbase Devesh 
Published: June 2022

Abstract
Located on the south-facing slope of the Himalayas, Nepal receives intense, long-lasting precipitation during the Asian summer monsoon, making Nepal one of the most susceptible countries to flood and landslide hazards in the region. However, sparse gauging and irregular measurement constrain the vulnerability assessments of floods and landslides which rely highly on the accuracy of precipitation. Therefore, this study evaluates the performance of Satellite-based Precipitation Products (SPPs) in the Himalayas region by comparing different datasets and identifying the best alternative of gauge-based precipitation for hydro-meteorological applications. We compared eight SPPs using statistical metrics and then used the Multi-Criteria Decision-Making (MCDM) technique to rank them. Secondly, we assessed the hydrological utility of SPPs by simulating through the GR4J hydrological model. We found a high POD (0.60–0.80) for all SPPs except CHIRPS and PERSIANN; however, a high CC (0.20–0.40) only for CHIRPS, IMERG_Final, and CMORPH. Based on MCDM, CMORPH and IMERG_Final rank first and second. While SPPs could not simulate daily discharge (NSE < 0.28), they performed better for monthly streamflow (NSE > 0.54). Overall, this study recommends CMORPH and IMERG_Final and improves the understanding of data quality to better manage hydrological disasters in the data-sparse Himalayas. This study framework can also be used in other Himalayan regions to systematically rank and identify the most suitable datasets for hydro-meteorological applications.
Evaluation of Base Slding Response and Effective Slab Width in the Ten-story Tests
Authors: Kabeyasawa Toshikazu , Kabeyasawa Toshimi , Xiongjie Cheng , Kang Jae-do , Nagae Takuya , Kajiwara Koichi 
Published: June 2022

Abstract
The ten-story full-scale shaking table tests conducted in 2015 and 2018 are simulated by analytical models such as being used in design practice or proposed in recent research and compared with the test data to simulate 1) the effective slab width on the beam capacities and 2) the base sliding and uplifting behavior. Three-dimensional pushover analysis used in the design practice of Japan was applied for the shake table tests with fixed base by varying the effective slab width on the beam to simulate the load-displacement relations and the lateral load carrying capacity in the tests. The effectiveness of slab and transverse beams was also evaluated in detail by the analysis with Timoshenko fiber beam element model applied partially for an outer span end in the wall direction. The analytical strains of slab reinforcement at the outer span end were compared with the measured in the tests. Three-dimensional nonlinear dynamic frame analyses with sliding base foundation models were carried out to simulate the responses of the superstructure and the sliding drift. Different types of simple base models were used where the two-way sliding and axial-shear interaction were considered at the center of the specimen while the horizontal base rotation was neglected. The response reduction of the superstructure owing to the sliding base could be approximated by either of base models, while still large discrepancy was observed in the sliding drifts among the test and the analyses.
A Low-Cost Physiological Monitoring Interface for Intensive Care Unit
Authors: Lin Ke-Feng , Lin Shih-Sung , Chen Ping-Nan 
Published: June 2022

Abstract
Background:During the COVID-19 pandemic, which emerged in 2020, many patients were treated in isolation wards because of the high infectivity and long incubation period of COVID-19. Therefore, monitoring systems have become critical to patient care and to safeguard medical professional safety. Objective:The user interface is very important to the surveillance system; therefore, we use web technology to develop a system that can create an interface based on user needs. When the surveillance scene needs to be changed, the surveillance location can be changed at any time, effectively reducing costs and time required, so that patients can achieve timely and appropriate goals of treatment.Methods:ZigBee was employed to develop a monitoring system for intensive care units (ICUs). Unlike conventional GUIs, the proposed GUI enables monitoring of various aspects of a patient, and the monitoring interface can be modified according to user needs. A simulated ICU environment monitoring system is designed to test the effectiveness of the system. The simulated environment and monitoring nodes were set up at positions consistent with the actual clinical environments to measure the time required to switch between monitoring scenes or targets on the GUI. Results:A low-cost system that can construct ZigBee-simulated graphical monitoring interfaces on demand was proposed in this study. The system can effectively overcome the limitations of conventional design methods for monitoring interfaces.Conclusion:This system can be used to simultaneously monitor the basic physiological data of numerous patients, enabling nursing professionals to instantly determine patient status and provide appropriate treatments. The proposed monitoring system can be applied to remote medical care after official adoption.
Screening and characterization of vaginal Lactobacillus as probiotic candidates
Authors: Zhu Chennuo , Huang Baoqi , Yu Changhao , Che Yuqing , Wu Dan , Wu Yue , Song Ping , Zhao Ye 
Published: June 2022

Abstract
Lactobacillus iners is often associated with vaginal dysbiosis and bacterial vaginosis (BV), which are risk factors for adverse gynecological and obstetric outcomes. Lactobacillus strains from the vagina of healthy women were screened for inhibitory activity against L. iners. Four active strains were identified, whereby L. gasseri H87 exhibited the highest inhibitory activity against L. iners, followed by L. rhamnosus H23. All four strains inhibited the growth of potential pathogens of the gastrointestinal, urogenital and reproductive tract, and were capable of co-aggregating with the cells of the tested pathogens to varying degrees. H23 and H78 were viable under in vitro conditions simulating the vaginal, gastric and intestinal environment, with survival rates > 80%. The four strains exhibited good auto-aggregation of more than 30%. H23 and H87 also exhibited good co-aggregation with Listeria monocytogenes and Escherichia coli, with values of more than 30%. Safety assessment showed that the four strains had the usual antibiotic susceptibility profile and did not produce hemolysins. Considering that H87 exhibited a better performance as a probiotic, we investigated the antibacterial substance produced by H87, and identified a bacteriocin with 6.5 kDa. Based on strain characteristics and beneficial properties, we believe that H87 is promising candidate for human trials to confirm its ability to prevent/treat vaginal dysbiosis and maintain a healthy vaginal ecosystem.
Risk Factors for COVID-19 Mortality in Pediatric Populations: A Scoping Review
Authors: Wijaya Jane Theophillia , Varshney Karan , Browning Samuel Dean , Fatima Syeda Zaheer , Shahrin Lubaba 
Published: June 2022

Abstract
Background Pediatric populations are generally considered to be at a lower risk of mortality from COVID-19 infection in comparison to adult populations. Regardless, a significant number of deaths from COVID-19 have been reported in pediatric populations internationally. We conducted a scoping review of the literature assessing the risk factors for COVID-19 mortality among pediatric patients. Methods A scoping review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR). Searches were performed in PubMed, Scopus, medRxiv, and WHO Coronavirus Database. There were no restrictions placed for searches based on date. Papers that were published in English, included at least one pediatric death from COVID-19, and described at least one risk factor for the death and/or clinical presentation of the child(ren) were eligible for inclusion. The pediatric population was defined as children aged 18 years and younger. Results Searches generated a total of 5787 papers and, 78 papers were eligible for analysis. There was a pooled total of 837 pediatric deaths. The presence of at least one comorbidity was a major risk factor; malignancies, cardiovascular diseases and overweight/obesity were the most frequently associated with mortality. The development of Pediatric Multisystem Inflammatory Syndrome (PMIS) was also consistently demonstrated to be a risk factor. Common clinical complications associated with pediatric COVID-19 infection resulting in mortality were sepsis, acute respiratory distress syndrome, and acute kidney injury. Conclusions Our review has identified prominent risk factors for mortality from COVID-19 infection amongst pediatric patients. Knowledge of these risk factors can assist prognostication and clinical decision-making for severe pediatric COVID-19 infections. Our findings will help shape public health guidelines and guide new treatment regimens for high-risk individuals.
Association of Lipid Composition and Unsaturated Fatty Acids of VLDL with Atrial Remodeling in Metabolic Syndrome
Authors: Lee Hsiang-Chun , Cheng Wei-Chung , Ma Wen-Lung , Lin Yu-Hsun , Shin Shyi-Jang 
Published: June 2022

Abstract
Background: Subjects with metabolic syndrome (MetS) commonly have atrial remodeling, which indicates a risk for atrial fibrillation. Objective: This study determined MetS-related changes in lipid components in very-low-density lipoprotein (VLDL), which has been shown causing atrial remodeling, and the effect of statins on these changes, and the correlation between atrial remodeling and VLDL lipid compositions. Methods: Blood samples were collected from 12 non-MetS and 27 sex- and age-matched MetS subjects. Fourteen patients with MetS (MetS­–off statin) discontinued statin therapy 14 days before the study, while the remaining 13 remained on it (MetS–on statin). The VLDLs were isolated and processed for mass-based lipid profiling. Lipidomic analyses were performed and associated with atrial remodeling markers measured using standard echocardiography and electrocardiography. Results: Compared with the VLDL components of the non-MetS group, glucosyl/galactosyl ceramide, lyso-phosphatidylcholine, lyso-phosphatidylethanolamine, and triglycerides were enriched in the MetS–off statin group. The statin therapy attenuated all abnormally abundant lipid classes in MetS, except for triglycerides. In addition, lyso-phosphatidylcholine, lyso-phosphatidylethanolamine, and triglycerides were significantly correlated with atrial dilatation, and the latter two were also correlated with the PR interval. Enrichment of double bonds, which indicates unsaturated fatty acids, was also significantly correlated with atrial remodeling, and P-wave duration. Conclusion: This study suggests that the pathological lipid payload of MetS-VLDL may contribute to atrial remodeling in patients.
Graded compression stockings significantly decreased the risk of deep vein thrombosis after total knee arthroplasty
Authors: Fu Kai , Qin Jianghui , Yao Yao , Zhen Liming , Zhang Yu , Wang Yexian , Shen Ying , Chen Dongyang , Jiang Qing 
Published: June 2022

Abstract
Objectives: To evaluate the effect of GCS on decreasing the incidence of postoperative DVT in patients after primary total knee arthroplasty.Method: A total of 226 patients who received primary TKA in Nanjing Drum Tower Hospital from Jan 1, 2018, to Jan 1, 2021 were enrolled. Depending on the presence of postoperative DVT, we divided the patients into 2 groups: the non-DVT group (n=192) and the DVT group (n=34). Parameters were compared using χ2 or t test between two groups. Binary logistic regression analysis was used to determine risk factors.Results: The incidence of postoperative DVT was 15% (n=34) in patients after TKA. Age, preoperative D-dimer and GCS usage were all associated with postoperative DVT. Compared to the non-DVT group, there was a significant increase in age (71.06±7.25 vs. 67.82±7.61, p=0.022) and preoperative D-dimer (1.51±2.21 vs. 0.92±1.39, p=0,042) in the DVT group. Moreover, the rate of GCS usage in the DVT group was significantly lower than that in the non-DVT group (23.5% vs. 48.4%, p=0.007). After adjusting for age, gender, preoperative D-dimer, and GCS usage by binary logistic regression analysis, GCS usage (OR = 2.950, 𝑃 = 0.013, 95% CI [1.261-6.901]) was an independent risk factor for postoperative DVT in patients after TKA.Conclusion: The overall prevalence of DVT was 15% in the current study, with 20.8% in non-GCS usage patients and 7.9% in GCS usage patients. GCS usage was an independent risk factor and could significantly decrease DVT risk in patients after TKA.
Acute Headache Management for Patients with Subarachnoid Hemorrhage: An International Survey of Healthcare Providers
Authors: Maciel Carolina B. , Barlow Brooke , Gobinathan Arravintha , Abu-Mowis Zaid , Peethala Mounika Mukherjee , Merck Lisa H. , Aspide Raffaele , Dickinson Katie , Miao Guanhong , Shan Guogen , Bilotta Federico , Morris Nicholas , Citerio Giuseppe , Busl Katharina M. , Lucke-Wold Brandon 
Published: June 2022

Abstract
Background: Severe headaches are common after subarachnoid hemorrhage (SAH). Guidelines recommend treatment with acetaminophen and opioids, but patient data show that headaches often persist despite multimodal treatment approaches. Considering an overall slim body of data for a common complaint affecting SAH patients during their intensive care stay, we set out to assess practice patterns in headache management among clinicians who treat patients with SAH.Methods: We conducted an international cross-sectional study through a 37-question web-based survey distributed to members of 5 professional societies relevant to intensive and neurocritical care from 11/2021-1/2022. Responses were characterized through descriptive analyses; Fisher’s exact test was used to test associations.Results: Of 516 responses, 329/497 (66%) were from North America and 121/497 (24%) from Europe. 379/435 (87%) reported headache as major management concern for SAH patients. Intensive-care-teams were primarily responsible for analgesia during hospitalization (249/435, 57%), while responsibility shifted to neurosurgery at discharge (233/501, 47%). Most used medications were acetaminophen (90%), opioids (66%), corticosteroids (28%) and antiseizure medications (28%). Opioids or medication combinations including opioids were most frequently perceived as most effective, by 169/433 (39%, predominantly intensivists), followed by corticosteroids or combinations with corticosteroids (96/433, 22%, predominantly neurologists). Of medications prescribed at discharge, acetaminophen was most common (303/381, 80%), followed by opioids (175/381 [46%]), and antiseizure medications (173/381, 45%). Opioids during hospitalization were significantly more prescribed by intensivists, by providers managing higher numbers of SAH patients, and in Europe. At discharge, opioids were more frequently prescribed in North America. 299/435 (69%) indicated no change in prescription practice of opioids with the opioid crisis. Additional differences in prescription patterns between continents and providers, and inpatient versus discharge were found. Conclusions: Post-SAH headache in the intensive care setting is a major clinical concern. Analgesia heavily relies on opioids both in utilization and in perception of efficacy, with no reported change in prescription patterns for opioids for most providers despite the significant drawbacks of opioids. Responsibility for analgesia shifts between hospitalization and discharge. International and provider-related differences are evident. Novel treatment strategies and alignment of prescription between providers are urgently needed.
Albumin mRNA and filamin-A are helpful for differentiating intrahepatic cholangiocarcinoma from extrahepatic origins
Authors: Chung Yeon Seung , Jeon Youngsic , Yoo Jeong Eun , Chung Taek , Rhee Hyungjin , Ryu Hyang Joo , Kim Hyunki , Park Young Nyun 
Published: June 2022

Abstract
Background: The differential diagnosis of intrahepatic cholangiocarcinomas (iCCAs) from metastatic adenocarcinomas from organs adjacent to the liver is difficult due to histopathological similarity and a lack of specific markers. This study evaluates the performance of albumin mRNA in situ hybridization (ISH) and immunohistochemistry (IHC) of filamin-A and cytokeratin 19 (CK19) for differential diagnosis.Methods: A total of 181 iCCAs and 116 adenocarcinomas from extrahepatic organs (30 gallbladder, 28 pancreas, and 58 stomach) were collected, and albumin ISH and IHC for filamin-A and CK19 were performed. The sensitivity, specificity, and the area under the curve (AUC) on the receiver operating characteristic (ROC) curve analysis of each marker were evaluated for the diagnosis of iCCA over extrahepatic adenocarcinoma.Results: Albumin ISH showed 23.2% sensitivity and 100% specificity for iCCAs, including both the small-duct and large-duct types. The expression of filamin-A and CK19 in albumin ISH-negative iCCAs was compared with that in extrahepatic adenocarcinomas. Filamin-A showed 71.1% sensitivity, 87.5% specificity, and 0.79 AUC on the ROC in small-duct-type iCCAs, whereas it had 27.5% sensitivity, 87.5% specificity, and 0.58 AUC on the ROC in large-duct-type iCCAs. CK19 showed 87.9% sensitivity, 59.4% specificity, and 0.74 AUC on the ROC in large-duct-type iCCAs, whereas it had 44.7% sensitivity, 59.4% specificity, and 0.52 AUC on the ROC in small-duct-type iCCAs.Conclusion: Albumin ISH and IHC for filamin-A and CK19 showed distinct expression patterns according to iCCA type. Albumin ISH positivity supports the possibility of iCCA, and filamin-A IHC is helpful for differentiating small-duct-type iCCA from extrahepatic adenocarcinomas.