bluuebunny/crossref_metadata_2025_split huggingface dataset:
Financial Leverage, Information Quality, and Efficiency*
Authors: Nan Lin , Wen Xiaoyan 
Published: December 2022

ABSTRACTWe examine information quality and financial leverage when an entrepreneur needs financing to undertake a risky project and his effort input affects the project's outcome. We show that information quality and financial leverage interact to play active roles in both investment and effort decisions. Our analysis shows a positive association between leverage and optimal information quality—when leverage is low (high), low (high) information quality is optimal. This is because with low leverage, the entrepreneur is already motivated by his large share of the outcome to exert effort, and high information quality is not efficient as a precise bad signal discourages the entrepreneur's effort. In contrast, when leverage is high and thus the entrepreneur is less motivated by his residual cash flows, high information quality is optimal, because a precise good signal encourages the entrepreneur's effort. Our study highlights the joint effect of information quality and financial leverage on overall efficiency through firms' effort inputs as well as on defining investment efficiency.
Sampling as ethnographic method/remixing Gulu City
Authors: Bitter Joella 
Published: December 2022

AbstractThis article describes the process of producing Gulu SoundTracks, a digital sonic ethnographic project accessible at gulusoundtracks.org, with four Ugandan music producers based in Gulu. The album comprises eight digital audio tracks that tell stories about Gulu musically through the compositional mixing of field soundscape recordings. Using field recordings as samples opened up sampling as a multimodal method for ethnographic storytelling which entails listening that is “vexed” (Weheliye 2005), archival, multiple, and generative. Pointing to insights from the project's creative process, the author explores sound praxis as a modality for amplifying fruitful connections between ethnographic and Afrodiasporic arts traditions. In conversation with others using sound methods in anthropology, ethnomusicology, and digital sound studies, this article stages a dialogue between sound‐based work, critical treatments of Black and Afrosonic cultural production, and experimental ethnography. Sampling as method centers ethnographic imagination and points to critical possibilities field recording holds for anthropological knowledge production.
Impact of farmer group participation on the adoption of sustainable farming practices—spatial analysis of New Zealand dairy farmers
Authors: Yang Wei , Wang Le 
Published: December 2022

AbstractThis paper analyzes the impact of participation in farmer groups on dairy farmers’ adoption of sustainable farming practices in New Zealand. A spatial propensity score matching method is used to consider the spatial dependence and social connections between farmers in the decision‐making of farmer group participation and adoption of sustainable farming practices. The results show that farmers’ decisions of farmer group participation are affected by their neighbors’ choices, and participation in farmer groups has a positive effect on farmers’ adoption of sustainable farming practices. The findings indicate the important role of social interactions in farmers’ voluntary uptake of sustainable agricultural practices. Overall, the positive effect of farmer group participation on the adoption of sustainable agricultural practices highlights learning and knowledge spillover among farmers, which emerges as important to the formulation of sustainable farming policy.
Oncological impact of cystoscopic findings in non‐muscle‐invasive bladder cancer: a meta‐analysis
Authors: Yanagisawa Takafumi , Quhal Fahad , Kawada Tatsushi , Mostafaei Hadi , Motlagh Reza Sari , Laukhtina Ekaterina , Rajwa Pawel , von Deimling Markus , Bianchi Alberto , Pallauf Maximilian , Majdoub Muhammad , Pradere Benjamin , Abufaraj Mohammad , Moschini Marco , Karakiewicz Pierre I. , Iwatani Kosuke , Miki Jun , Kimura Takahiro , Shariat Shahrokh F. 
Published: December 2022

ObjectiveTo assess the association between cystoscopic findings and oncological outcomes in patients with non‐muscle‐invasive bladder cancer (NMIBC) given that the oncological impact of quantity and quality assessment of tumours with cystoscopy has not been well verified.MethodsMultiple databases were queried in May 2022 for studies investigating the association of oncological outcomes, such as recurrence‐free (RFS), progression‐free (PFS), and cancer‐specific survival (CSS), with cystoscopic findings, including multiplicity, size, and gross appearance of tumours in patients with NMIBC.ResultsOverall, 73 studies comprising 28 139 patients were eligible for the meta‐analysis. Tumour multiplicity was associated with worse RFS (pooled hazard ratio [HR] 1.61, 95% confidence interval [CI] 1.48–1.74) and PFS (pooled HR 1.44, 95% CI 1.18–1.76) in NMIBC patients (including both Ta and T1). Tumour size (≥3 cm) was associated with worse RFS (pooled HR 1.97, 95% CI 1.69–2.30) and PFS (pooled HR 1.81, 95% CI 1.52–2.15) in NMIBC patients. In patients with T1 bladder cancer (BCa), tumour multiplicity and size (≥3 cm) were also associated with worse RFS, PFS and CSS. By contrast, among patients treated with bacillus Calmette‐Guérin (BCG), tumour multiplicity was not associated with worse RFS, and tumour size (≥3 cm) was not associated with worse PFS. Sessile tumours were associated with worse RFS (pooled HR 2.14, 95% CI 1.52–3.01) and PFS (pooled HR 2.17, 95% CI 1.42–3.32) compared to pedunculated tumours. Compared to papillary tumours, solid tumours were associated with worse RFS (pooled HR 1.84, 95% CI 1.25–2.72) and PFS (pooled HR 3.06, 95% CI 2.31–4.07) in NMIBC patients, and CSS in T1 BCa patients (pooled HR 2.32, 95% CI 1.63–3.30).ConclusionsCystoscopic findings, including tumour multiplicity, size, and gross appearance, strongly predict oncological outcomes in NMIBC patients. Cystoscopic visual features can help in the decision‐making process regarding the timeliness and extent of tumour resection as well as future management such as intravesical therapy.
The sigma‐1 receptor curtails endogenous opioid analgesia during sensitization of TRPV1 nociceptors
Authors: Ruiz‐Cantero M. Carmen , Cortés‐Montero Elsa , Jain Aakanksha , Montilla‐García Ángeles , Bravo‐Caparrós Inmaculada , Shim Jaehoon , Sánchez‐Blázquez Pilar , Woolf Clifford J. , Baeyens José M. , Cobos Enrique J. 
Published: December 2022

AbstractBackground and PurposePeripheral sensitization contributes to pathological pain. While prostaglandin E2 (PGE2) and nerve growth factor (NGF) sensitize peptidergic C‐nociceptors (TRPV1+), glial cell line‐derived neurotrophic factor (GDNF) sensitizes non‐peptidergic C‐neurons (IB4+). The sigma‐1 receptor (sigma‐1R) is a Ca2+‐sensing chaperone known to modulate opoid analgesia. This receptor binds both to TRPV1 and the μ opioid receptor, although the functional repercussions of these physical interactions in peripheral sensitization are unknown.Experimental ApproachWe tested the effects of sigma‐1 antagonism on PGE2‐, NGF‐, and GDNF‐induced mechanical and heat hyperalgesia in mice. We used immunohistochemistry to determine the presence of endomorphin‐2, an endogenous μ receptor agonist, on dorsal root ganglion (DRG) neurons. Recombinant proteins were used to study the interactions between sigma‐1R, μ‐ receptor, and TRPV1. We used calcium imaging to study the effects of sigma‐1 antagonism on PGE2‐induced sensitization of TRPV1+ nociceptors.Key ResultsSigma1 antagonists reversed PGE2‐ and NGF‐induced hyperalgesia but not GDNF‐induced hyperalgesia. Endomorphin‐2 was detected on TRPV1+ but not on IB4+ neurons. Peripheral opioid receptor antagonism by naloxone methiodide or administration of an anti‐endomorphin‐2 antibody to a sensitized paw reversed the antihyperalgesia induced by sigma‐1 antagonists. Sigma‐1 antagonism transfers sigma‐1R from TRPV1 to μ receptors, suggesting that sigma‐1R participate in TRPV1‐μ receptor crosstalk. Moreover, sigma‐1 antagonism reversed, in a naloxone‐sensitive manner, PGE2‐induced sensitization of DRG neurons to the calcium flux elicited by capsaicin, the prototypic TRPV1 agonist.Conclusion and ImplicationsSigma‐1 antagonism harnesses endogenous opioids produced by TRPV1+ neurons to reduce hyperalgesia by increasing μ receptor activity.
Phase 1 trial of zolbetuximab in Japanese patients with CLDN18.2+ gastric or gastroesophageal junction adenocarcinoma
Authors: Shitara Kohei , Kawazoe Akihito , Hirakawa Akihiro , Nakanishi Yuka , Furuki Satomi , Fukuda Musashi , Ueno Yoko , Raizer Jeffrey , Arozullah Ahsan 
Published: December 2022

AbstractZolbetuximab is a chimeric monoclonal antibody that targets claudin‐18.2, a candidate biomarker in patients with advanced gastric/gastroesophageal cancer. This nonrandomized phase 1 study (NCT03528629) enrolled previously treated Japanese patients with claudin‐18.2–positive locally advanced/metastatic gastric/gastroesophageal cancer in two parts: Safety (Arms A and B, n = 3 each) and Expansion (n = 12). Patients received intravenous zolbetuximab 800 mg/m2 on cycle 1, day 1 followed by 600 mg/m2 every 3 weeks (Q3W; Safety Part Arm A and Expansion) or 1000 mg/m2 Q3W (Safety Part Arm B). For the Safety Part, the primary endpoint was safety (i.e., dose‐limiting toxicities [DLTs]) and a secondary endpoint was objective response rate (ORR) by investigator. For the Expansion Part, the primary endpoint was ORR by investigator and secondary endpoints included ORR by central review and safety. Additional secondary endpoints for both the Safety and Expansion Parts were disease control rate (DCR), overall survival (OS), progression‐free survival (PFS), duration of response, pharmacokinetics, and immunogenicity. In 18 patients, no DLTs (Safety Part) or drug‐related treatment‐emergent adverse events (TEAEs) grade ≥3 were observed. Most TEAEs were gastrointestinal. In 17 patients with measurable lesions, best overall response was stable disease (64.7%) or progressive disease (35.3%). The DCR was 64.7% (95% confidence interval 38.3–85.8). In Arm A and Expansion combined (n = 15), median OS was 4.4 months (2.6–11.4) and median PFS was 2.6 months (0.9–2.8). In Arm B (n = 3), median OS was 6.4 months (2.9–6.8) and median PFS was 1.7 months (1.2–2.1). Zolbetuximab exhibited no new safety signals with limited single‐agent activity in Japanese patients.
A prospective study comparing itraconazole alone versus systemic steroids alone as adjuncts to topical steroids in the post‐operative management of allergic fungal rhinosinusitis
Authors: Salil Amala , Joy Nedha , Faizal Bini 
Published: December 2022

AbstractObjectivesThe objective of this study was to compare the efficacy of itraconazole and systemic steroids as an adjuvant to topical steroids in post‐operative patients with allergic fungal rhinosinusitis (AFRS) using both subjective and objective outcome measurements.DesignA prospective comparative study.SettingA tertiary care centre.ParticipantsSixty patients diagnosed with AFRS were included. Patients with chronic systemic illness and those undergoing revision surgery were excluded. Post‐operative patients were divided into two groups of 30 each which received itraconazole 400 mg OD or methylprednisolone in tapering doses over 6 weeks.Main outcome measuresThe outcomes were measured at the end of 6 weeks—Kupferberg endoscopic staging, absolute eosinophilic count (AEC), serum immunoglobulin (IgE), and Sino Nasal Outcome Test‐20 scores.ResultsOur study showed no statistical significance in outcomes between the two groups treated with itraconazole and methylprednisolone regarding recurrence, AEC, IgE and quality of life assessment (p < 0.01).ConclusionItraconazole was comparable to methylprednisolone in preventing disease recurrence in the post‐operative management of AFRS. It may be a viable alternative to replacing systemic steroids where the latter may be contraindicated. Itraconazole given at a dose of 400 mg once daily for 6 weeks was a safe dose.
Faecal immunochemical testing reduces demand and improves yield of Leicester's 2‐week pathway for change in bowel habit
Authors: Khasawneh Farah , Osborne Timothy , Danaher Paul , Barnes Daniel , Chapman Caroline J. , Stephenson James A. , Singh Baljit 
Published: December 2022

AbstractAimWe look at the effect of introducing the faecal immunochemical test (FIT) in the straight‐to‐test 2‐week pathway for change in bowel habit (CIBH).MethodThe FIT in primary care triages 2‐week wait (2WW) colorectal referrals for patients aged 60 years and above for straight‐to‐test CT colonography (CTC). We compare the impact of the FIT on numbers of 2WW CTCs, in the year before and after FIT, in both colorectal cancer (CRC) detection and cost‐effectiveness at both 4 μg Hb/g faeces and 10 μg Hb/g faeces.ResultsAt a threshold of 4 μg Hb/g faeces, the positive predictive value of the FIT for diagnosis of CRC is 5.0% with a negative predictive value of 99.8% and a polyp detection rate of 25.5%. The introduction of the FIT resulted in a reduction in the number of CTCs performed through the CIBH pathway from a mean of 143.9 per month prior to the FIT to 66.8 CTCs per month once the FIT was well established. Given a FIT threshold of 10 μg Hb/g the number of CTCs would be predicted to fall by 70.4% to 42.6 CTCs per month resulting in higher CRC and polyp detection rate, and an estimated annual cost saving of £238 258 in our institution.ConclusionThe FIT use in primary care improves the yield of 2WW referrals for CIBH alone and reduces the burden and cost of investigations to exclude CRC. Improvements may be possible by increasing the cut‐off employed, without adversely affecting the risk of missing a cancer.
Chromic textiles: Colour fastness properties and irreversible colour change behaviour of textiles screen printed with thermochromic, photochromic and hydrochromic colourants
Authors: Cabral Isabel , Santiago Diana , Steffens Fernanda 
Published: December 2022

AbstractThe objective of this work was to study how ultraviolet (UV) light exposure, washing and rubbing can influence colour and dynamic qualities of chromic textiles, and to explore how the results attained can be applied by designers for the development of colour changing palettes. The experimental work was conducted with 74% polyamide and 26% elastane elastics screen printed with thermochromic, photochromic and hydrochromic pigments in diverse colours. Initially, colourfastness properties of each pigment type versus colour were assessed. Although washing and rubbing can interfere in samples' colours by becoming lighter at different degrees, the results attained highlight the poor stability to lighting of thermochromic and photochromic pigments, which also present changes between hues along exposure time. For conventional textile applications, poor colour fastness commonly represents a limitation. This work proposes that the way textile colours and behaviour are permanently affected by the studied conditions can be interpreted as a creative variable in the design process. Research samples with a combination of pigments were developed and tested with a combination of cycles of different fastness tests, namely one washing cycle for every 4 h of UV light exposure, totalling 48 h and 12 washing cycles. Results demonstrate the possibility of creating interactive surfaces capable of displaying a wide range of colours that evolve to static within different hues, over stimuli conditions.
Fluoride detection with a colorimetric and fluorescent dual‐mode chemosensor
Authors: Song Chanwoo , Gil Dongkyun , Lee Jae Jun , Jung Sumin , Kim Cheal 
Published: December 2022

AbstractWe designed a colorimetric and fluorescent dual‐mode chemosensor ADM ((E)‐2‐(((2‐amino‐4,5‐dichlorophenyl)imino)methyl)‐6‐methoxyphenol) for detecting fluoride (F−). The sensor ADM can detect F− by colour and fluorescence changes. The colour change is from colourless to yellow, and the fluorescence change is a yellow turn‐on. With the results of Job plot and electrospray ionisation mass spectrometry, the reaction of F− and ADM turned out to be a 1:1 binding. The detection limits for F− of ADM were 5.00 μM in ultraviolet–visible and 4.16 μM in fluorescence. The detecting process of F− by ADM was demonstrated by ultraviolet–visible and fluorescent titrations, electrospray ionisation mass spectrometry, proton nuclear magnetic resonance titration and theoretical calculations.
CDT1 is the major functional regulatory subunit of the pre‐replication complex in zygotes
Authors: Li Chao , Tan Yong‐Peng , Ma Xue‐Shan , Wang Zhen‐Bo , Meng Tie‐Gang , Sun Qing‐Yuan 
Published: December 2022

AbstractPre‐replication complex (pre‐RC) is critical for DNA replication initiation. CDT1 and MCM2 are the subunits of pre‐RC, and proper regulation of CDT1 and MCM2 are necessary for DNA replication and cell proliferation. The present study aimed to explore the role of CDT1 and MCM2 in oocyte meiotic maturation and early embryonic development. The depletion and overexpression of Cdt1 and Mcm2 in oocyte and zygote were achieved by microinjecting specific siRNA and mRNA to explored their functions in oocyte meiotic maturation and embryonic development. Then, we examined the effect of CDT1 and MCM2 on other signal pathways by immunostaining the expression of related maker genes. We showed that neither depletion nor overexpression of Cdt1 affected oocyte meiotic progressions. The CDT1 was degraded in S phase and remained at a low level in G2 phase of zygote. Exogenous expression of Cdt1 in G2 phase led to embryo attest at zygote stage. Mechanistically, CDT1 overexpression induced DNA re‐replication and thus DNA damage check‐point activation. Protein abundance of MCM2 was stable throughout the cell cycle, and embryos with overexpressed MCM2 could develop to blastocysts normally. Overexpression or depletion of Mcm2 also had no effect on oocyte meiotic maturation. Our results indicate that pre‐RC subunits CDT1 and MCM2 are not involved in oocyte meiotic maturation. In zygote, CDT1 but not MCM2 is the major regulator of DNA replication in a cell cycle dependent manner. Furthermore, its' degradation is essential for zygotes to prevent from DNA re‐replication in G2 stage.
Effectiveness and safety of early insulin glargine administration in combination with continuous intravenous insulin infusion in the management of diabetic ketoacidosis: A randomized controlled trial
Authors: Thammakosol Kitti , Sriphrapradang Chutintorn 
Published: December 2022

AbstractAimTo determine the effectiveness and safety of early combination of insulin glargine with intravenous (IV) insulin infusion compared with IV insulin infusion alone in the management of diabetic ketoacidosis (DKA).MethodsThis was a single‐centre, open‐label, randomized controlled trial of adults aged 18 years or older diagnosed with DKA. The ‘early glargine’ group was given subcutaneous insulin glargine 0.3 units/kg within the first 3 hours of DKA diagnosis, in addition to the standard IV insulin infusion. The control group received standard IV insulin treatment only. The primary outcome was the time to DKA resolution. The other outcomes included rebound hyperglycaemia, mortality, hypoglycaemia and hypokalaemia, as well as the length of hospital stay (LOS).ResultsA total of 60 patients (30 patients per group) were enrolled. Most patients (76.7%) had type 2 diabetes. Both groups were similar in baseline characteristics, except for higher serum beta‐hydroxybutyrate and lower pH levels in the early glargine group. The mean ± standard deviation time to DKA resolution in the early glargine group was significantly faster than the control group (9.89 ± 3.81 vs. 12.73 ± 5.37 hours; P = .022). The median (interquartile range) LOS was significantly shorter in the early glargine group than in the control group (4.75 [3.53‐8.96] vs. 15.25 [5.71‐26.38] days; P = .024). The incidence of rebound hyperglycaemia, all‐cause mortality, hypoglycaemia and hypokalaemia was similar between the groups.ConclusionsEarly combination of insulin glargine with IV insulin infusion led to a faster DKA resolution and a shorter LOS, without increasing hypoglycaemia and hypokalaemia.
Female labour, status and decision power
Authors: Bros Catherine , Gille Véronique , Maniquet François 
Published: December 2022

AbstractThis paper investigates the role of (perceived or own) norm cost in the relationship between female labour supply and decision power, which we define as the say that women have in major household decisions. We propose a model where female labour supply and decision power are set jointly following a bargaining process. Taking into account the fact that men may lose status when having a working wife, we show that decision power and female labour supply can be negatively correlated. We test the predictions of our model using Indian panel data. We find that the relationship is negative in contexts where the norm cost of having a working wife is high.
Culture and the labor supply of female immigrants
Authors: Bredtmann Julia , Otten Sebastian 
Published: December 2022

AbstractThis paper analyzes the impact of source‐country culture on the labor supply of female immigrants in Europe. We find that the labor supply of immigrant women is positively associated with the female‐to‐male labor force participation ratio in their source country, which serves as a proxy for the country's preferences and beliefs regarding women's roles. This suggests that the culture and norms of their source country play an important role for immigrant women's labor supply. However, contradicting previous evidence for the US, we do not find evidence that the cultural effect persists through the second generation.
Community structure and antifungal activity of actinobacteria in a fungus‐growing termite
Authors: Chen Siqi , Cheng Daifeng , Liu Zhen , Hassan Babar , Xu Yijuan 
Published: December 2022

Abstract
Fungus‐growing termites cultivate the fungal mutualist Termitomyces as their main food source; however, how fungus‐growing termites protect Termitomyces from threats is still unclear. In this study, we investigated the actinobacterial communities in Odontotermes formosanus individuals and their fungal combs.
Moreover, the antifungal activities of the isolated actinobacteria were tested. 16 S rRNA gene sequencing results indicated that the actinobacteria in O. formosanus and its fungal combs belong to 5 classes, 17 orders, 40 families, and 84 genera.
The relative abundance of Coriobacteriia in the nymphs, young workers, old workers, and soldiers was higher than that in the queens and fungal combs, and the relative abundance of class Actinobacteria in the queens and the fungal combs was higher than that in the nymphs, young workers, old workers, and soldiers.
Based on antifungal bioassays, 3 strains of Amycolatopsis and 2 strains of Streptomyces isolated from old workers had strong inhibitory activity against Xylaria angulosa but weak inhibitory activity against Termitomyces sp.
These results indicated that the actinobacteria of O. formosanus may contribute to protecting termite fungal food via their asymmetric antifungal activities.