bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penyuluhan Kesehatan Mengenai Teknik Menyusui Di Desa Liman Benawi Lampung Tengah
Authors: Utami Vida Wira , Evrianasari Nita , Lutfiana Vina 
Published: August 2022

Pendahuluan Pentingnya pengetahuan ibu mengenai teknik menyusui yang benar mempengaruhi keberhasilan dalam memberikan ASI. Faktor-faktor yang mempengaruhi keberhasilan ibu dalam menyusui ibu yaitu faktor psikologis, faktor fisik, pekerjaan, pengatahuan dan partisipasi suami/keluarga. Manfaat dari teknik menyusui yang benar yaitu putting susu tidak lecet, perlekatan menyusu pada bayi kuat, bayi menjadi tenang dan tidak terjadi gumoh. Menyusui dengan teknik yang tidak benar selain juga menyebabkan putting susu lecet dapat juga menyebabkan asi tidak keluar secara optimal sehingga produksi asi menurun dan bayi tidak mau menyusu kembali, Menurut berbagai penelitian pemberian ASI ekskulsif minimal 6 bulan. . Oleh karena itu sangat diperlukannya kesadaran akan pentingnya teknik menyusui.Tujuan untuk memberikan informasi mengenai teknik menyusui yang benar agar bayi mendapatkan asupan yang bergizi dan meningkatkan kedekatan ibu anak.Metode Kegiatan penyuluhan berupa presentasi dan praktik mengenai teknik menyusui yang benar. Hasil dari kegiatan ini peserta dapat mengaplikasikan materi presentasi melalui praktik yang dilakukan dengan baik dan benar.Kesimpulan Membuktikan bahwa penyuluhan telah berhasil dilakukan. Kata Kunci : Teknik menyusui, penyuluhan, kesehatan. ABSTRACT Introoduction The importance of mother's knowledge about the correct breastfeeding technique affects the success of breastfeeding. The factors that influence the success of mothers in breastfeeding mothers are psychological factors, physical factors, work, knowledge and participation of husband/family. The benefits of the correct breastfeeding technique are that the nipple does not blister, the attachment of breastfeeding to the baby is strong, the baby becomes calm and does not spit up. Breastfeeding with incorrect techniques, besides causing sore nipples, can also cause breast milk to not come out optimally so that milk production decreases and the baby does not want to breastfeed again, according to various studies of exclusive breastfeeding for at least 6 months. Therefore, it is very necessary to be aware of the importance of breastfeeding techniques. The Purpose to provide information on correct breastfeeding techniques so that babies get nutritious intake and increase the closeness of mothers to children. Methods Through counseling in the form of presentations and practices regarding correct breastfeeding techniques. Result of this activity, participants were able to apply the presentation material through good and correct practice. Conclusion Proving that the counseling has been carried out successfully. Keywords : Breastfeeding techniques, counseling, health
Representación de la mujer en la sociedad de Aguascalientes durante la época del Porfiriato
Authors: Olvera Trejo Laura 
Published: August 2022

El siguiente artículo tiene como objetivo analizar el rol y la representación de la mujer en la sociedad de la época porfiriana, particularmente a través del caso de Aguascalientes, a partir de documentos, periódicos y publicidad escritos por hombres y mujeres en el siglo XIX, que permiten entender cuál era el discurso de los roles y la representación de la mujer durante esa época. Además, de las fuentes bibliográficas sobre el tema, que brindan un panorama internacional y nacional. Al mismo tiempo, se buscó comprender las transformaciones de la representación de la mujer a partir del caso del Liceo de Niñas en Aguascalientes.
Las Exposiciones Universales: La participación de México a través del escultor Jesús F. Contreras en 1889
Authors: Rodríguez López María Guadalupe 
Published: August 2022

La presente investigación se centra en la participación del escultor Jesús F. Contreras en la Exposición Universal de París de 1889, el cual se encargó de realizar todo lo que se expuso en el pabellón presentado por México. El proyecto que se presentó fue El Palacio Azteca, propuesto por Anza y Peñafiel; mismo que incluía esculturas de dioses y reyes aztecas. Cabe destacar que los lineamientos para la creación de las figuras fueron establecidos por Contreras, desdeñando los planteados por Peñafiel.
Además Contreras apoyó al escultor José María Velasco como delegado del gobierno mexicano en uno de los congresos que se llevaron a cabo durante la exposición.
Fabrication of multifunctional alginate microspheres containing hydroxyapatite powder for simultaneous cell and drug delivery
Authors: Kim Jueun , Choi Yeong-Jin , Park Honghyun , Yun Hui-suk 
Published: August 2022

Novel alginate-hydroxyapatite hybrid microspheres were developed for simultaneous delivery of drugs and cells as a multifunctional bone substitute for osteoporotic bone tissue regeneration. The microspheres were used to enhance osteogenesis and to carry and deliver quercetin, a representative phytoestrogen that controls bone tissue regeneration metabolism in osteoporosis patients, through sustained release over a long period. To overcome quercetin’s hydrophobicity and low solubility in aqueous environments, we added it to the surface of hydroxyapatite (HAp) nanoparticles before mixing them with an alginate solution. The homogeneous distribution of the HAp nanoparticles in the alginate solution was essential for preventing nozzle clogging and achieving successfully fabricated hybrid microspheres. To this end, a 3D ultrasonic treatment was applied. Electrostatic microencapsulation was then used to fabricate hybrid alginate-HAp microspheres containing quercetin and cells. The microspheres were approximately 290.7 ± 42.5 μm (aspect ratio of 1). The sustained release of quercetin was confirmed during a test period of 20 weeks. The cells in the hybrid microspheres maintained good cell viability during the entire testing period, and their osteogenic differentiation behavior was boosted by the presence of HAp. Thus, osteogenic differentiation could be greatly improved by adding quercetin. These novel multi-biofunctional hybrid microspheres have great potential for the regeneration of osteoporotic bone tissue at indeterminate defect sites.
Assessment of Serum Free Light Chains as a Marker of Diabetic Nephropathy; A Cross-Sectional Study in the Kumasi Metropolis
Authors: Sorvor Elizabeth , Owiredu William K. B. A. , Okyere Perditer , Annani-Akollor Max Efui , Donkor Sampson , Bannor Richard , Sorvor Felix B.K. , Ephraim Richard K.D. 
Published: August 2022

AimsAlthough traditional tests such as serum urea, creatinine, and microalbuminuria have been widely employed in the diagnosis of diabetic nephropathy, their sensitivity and accuracy are limited because kidney damage precedes the excretion of these biomarkers. This study investigated the role of serum free light chains in the disease manifestation of diabetic nephropathy.Materials and MethodsUsing a cross-sectional design we recruited 107 diabetes mellitus out-patients who visited the Diabetes and Renal Disease Clinics at the Komfo Anokye Teaching Hospital, Manhyia District Hospital, and Suntreso Government Hospital all in Ghana from November 2019 to February 2020. Five (5) mls of blood was collected from each participant and analyzed for fasting blood glucose (FBG) urea, creatinine, immunoglobulin free light chains. Urine samples were obtained and analyzed for albumin. Anthropometric characteristics were also measured. Data were analyzed using descriptive analysis, analysis of variance (ANOVA) test, Tukey HSD post hoc, and Kruskal Wallis test. Chi-squared test was used to examine if there are significant associations with the indicators of interest. In addition, Spearman’s correlation was used to test for associations between appropriate variables. Receiver operating characteristic analysis (ROC) was also performed to assess the diagnostic performance of free light chains.ResultsThe mean age of studied participants was 58.2 years (SD: ± 11.1), 63.2% were females and most of the participants were married (63.0%). The mean FBG of the studied participants was 8.0mmol/L (SD: ± 5.86), and the average duration of diabetes mellitus (DM) was 11.88 years (SD: ± 7.96). The median serum Kappa, Lambda, and Kappa: Lambda ratios for the studied participants were 18.51 (15.63-24.18), 12.19(10.84-14.48), and 1.50(1.23-1.86) respectively. A positive correlation was observed between albuminuria and; Kappa (rs=0.132; p=0.209), and Lambda (rs=0.076; p=0.469). However, a negative correlation was observed between albuminuria and K: L ratio (rs=-0.006; p=0.956).ConclusionsThe current study observed an increasing trend in the levels of free light chains and degree of diabetic nephropathy, although not statistically significant. The exploration of serum free light chains as a better marker of diabetic nephropathy showed very promising results but further studies are required to elucidate its predictive value as a diagnostic tool for diabetic nephropathy.
Key ferroptosis-related genes in abdominal aortic aneurysm formation and rupture as determined by combining bioinformatics techniques
Authors: Ren Jinrui , Lv Yanze , Wu Lianglin , Chen Siliang , Lei Chuxiang , Yang Dan , Li Fangda , Liu Changzheng , Zheng Yuehong 
Published: August 2022

ObjectivesAbdominal aortic aneurysm (AAA) is a cardiovascular disease with high mortality and pathogenesis closely related to various cell death types, e.g., autophagy, apoptosis and pyroptosis. However, the association between AAA and ferroptosis is unknown.MethodsGSE57691 and GSE98278 dataset were obtained from the Gene Expression Omnibus database, and a ferroptosis-related gene (FRG) set was downloaded from the FerrDb database. These data were normalized, and ferroptosis-related differentially expressed genes (FDEGs, AAA vs. normal samples) were identified using the limma package in R. FRGs expression was analyzed by Gene Set Expression Analysis (GSEA), and FDEGs were analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes (KEGG) pathway enrichment analyses using the clusterProfiler package in R and ClueGO in Cytoscape. Protein–protein interaction networks were assembled using Cytoscape, and crucial FDEGs were identified using CytoHubba. Critical FDEG transcription factors (TFs) were predicted with iRegulon. FDEGs were verified in GSE98278 set, and key FDEGs in AAA (compared with normal samples) and ruptured AAA (RAAA; compared with AAA samples) were identified. Ferroptosis-related immune cell infiltration and correlations with key genes were analyzed by CIBERSORT. Key FEDGs were reverified in Ang II-induced AAA models of ApoE–/– and CD57B/6J mice by immunofluorescence assay.ResultsIn AAA and normal samples, 40 FDEGs were identified, and the expression of suppressive FRGs was significantly downregulated with GSEA. For FDEGs, the GO terms were response to oxidative stress and cellular response to external stimulus, and the KEGG pathways were the TNF and NOD-like receptor signaling pathways. IL6, ALB, CAV1, PTGS2, NOX4, PRDX6, GPX4, HSPA5, HSPB1, and NCF2 were the most enriched genes in the crucial gene cluster. CEBPG, NFAT5, SOX10, GTF2IRD1, STAT1, and RELA were potential TFs affecting these crucial genes. Ferroptosis-related immune cells involved in AAA formation were CD8+ T, naive CD4+ T, and regulatory T cells (Tregs); M0 and M2 macrophages; and eosinophils. Tregs were also involved in RAAA. GPX4, SLC2A1, and PEBP1 expression was downregulated in both the RAAA and AAA samples. GPX4 and PEBP1 were more important in AAA because they influenced ferroptosis-related immune cell infiltration, and SLC2A1 was more important in RAAA.ConclusionsThis is the first study to show that ferroptosis is crucial to AAA/RAAA formation. The TNF and NOD-like signaling pathways and ferroptosis-related immune cell infiltration play key roles in AAA/RAAA. GPX4 is a key ferroptosis-related gene in AAA. Ferroptosis and related genes might be promising targets in the treatment of AAA/RAAA.
Coronary computed tomography angiography as a screening tool for moderate-high risk asymptomatic type 2 diabetes mellitus patients
Authors: Liu Qiaolu , Qiu Jianfeng , Sun Shuxin , Wang Xiaoqiang , Sun Zhanguo , Zhao Huihui 
Published: August 2022

BackgroundThere are few data on the clinical significance of coronary computed tomography angiography (CCTA) in asymptomatic type 2 diabetes mellitus (T2DM) patients. We performed a retrospective study to evaluate coronary heart disease (CHD) screening in asymptomatic patients with T2DM using CCTA and CHD risk stratification prediction.Materials and methodsData from 141 T2DM patients (58 ± 8 years, 57% males) without known symptoms suggestive of CHD who underwent CCTA were retrospectively analyzed. The patients were classified into three subgroups based on United Kingdom prospective diabetes study (UKPDS) CHD risk stratification prediction. Seventy-four patients without diabetes mellitus and CHD who underwent CCTA successively were chosen as the control group. The segment involvement score (SIS), segment stenosis score (SSS), stenosis coefficient (SC), severe proximal plaque (SPP) positive ratio and CCTA-adapted Leaman score (CT-LeSc) based on CCTA data were evaluated and compared among the groups.ResultsCompared with the patients in the control group, patients in the moderate-high risk DM groups had higher scores on the SIS, SSS, SC, CT-LeSc, and a higher SPP positive ratio (all p-values &lt; 0.001), and no difference was observed between the low-risk group and the control group (p = 0.136, p = 0.088, p = 0.0.067, p = 0.225, p = 1.000, respectively). Compared with patients in the control group, the patients in the moderate-high risk DM groups had increased odds of SIS &gt; 3 [odds ratio (OR) = 6.557, p &lt; 0.001; OR = 4.455, p &lt; 0.001, respectively], SSS &gt; 5 (OR = 5.727, p &lt; 0.001; OR = 5.144, p &lt; 0.001, respectively), CT-LeSc &gt; 8.7 (OR = 3.780, p = 0.001; OR = 2.804, p = 0.007, respectively), and obstructive stenosis (OR = 7.233, p &lt; 0.001; OR = 5.787, p &lt; 0.001, respectively).ConclusionThe moderate-high CHD risk patients had increased odds of obstructive coronary artery stenosis, and the distribution of coronary artery stenosis was more extensive and more severe in that group compared to the patients without diabetes mellitus and CHD. CHD can be effectively screened in moderate-high risk asymptomatic T2DM patients using CCTA.
Exploring the role of uterine fibroids in promotion of cardiovascular diseases by diabetes exposure: Findings from national health and nutrition examination survey 1999–2006
Authors: Li Bin , Yuan Zhen , Zhang Yizhi , Li Feng , Huang Lin , Yang Zhihui , Liu Haiyue , Liu Zuheng 
Published: August 2022

ObjectiveThe relationship between uterine fibroids (UF) and cardiovascular diseases (CVDs) in the diabetes population seemed to remain undetermined in previous studies. This study aims to explore the association between UF and CVDs by using the database from the National Health and Nutrition Examination Survey (NHANES). To further evaluate the connection between UF and CVDs we also tested the potential differences due to diabetes exposure.Materials and methodsNational Health and Nutrition Examination Survey data (1999–2006) were collected and used in this study. A total of 5,509 individuals were included and analyzed. The student’s t-test and the chi-squared test were used to explore the demographic characteristic between UF and non-UF groups. Logistic regression analysis was performed to determine the odds ratios of UF and covariates.ResultsFemale participants were divided into UF (n = 694, 12.60%) and non-UF (n = 4,815, 87.40%) groups. The incidence of CVDs in UF patients (n = 245, 35.30%) were higher than non-UF individuals (n = 776, 16.12%) (p &lt; 0.001). In addition, each subtype of CVDs were also different, which contains hypertension (33.29 vs. 15.31%, p &lt; 0.001), heart failure (1.59 vs. 0.52%, p &lt; 0.01), angina (2.59 vs. 0.62%, p &lt; 0.001), heart attack (1.73 vs. 0.58%, p &lt; 0.01) and coronary heart disease (1.44 vs. 0.54%, p &lt; 0.01). The odds ratios of CVDs according to logistic regression were 2.840 (95% CI: 2.387–3.379) for UF patients (p &lt; 0.001), while the odds ratios (ORs) were 1.438 (95% CI: 1.175–1.760) after taking account for the age, body mass index (BMI), diabetes, race, education, and annual family income (p &lt; 0.001). In addition, secondary analysis indicated more adverse effects in by UF exposure on CVDs risk among non-diabetes individuals (OR = 1.389, 95% CI = 1.124–1.718, p &lt; 0.01) than diabetes patients (p = 0.063).ConclusionOverall, UFs were positively associated with CVDs, and this effect seems blunted by diabetes exposure.
Mechanical properties and instability analysis of concrete specimens with horizontal holes of different diameters
Authors: Fang Juejing , Yang Ke , Lyu Xin , Tang Jinzhou , Zhang Jiqiang 
Published: August 2022

Uniaxial compression tests were carried on 12 concrete specimens with six different diameter holes using a rigid test machine, and the stress–strain relationship was analyzed in different hole diameter specimens. The effects of different hole diameters on specimen compression strength, elastic modulus, and Poisson’s ratio were studied, and the failure form and instability mode of concrete specimens with holes of different diameters were evaluated. The results show that the larger the compression strength of the specimen, the larger the axial and horizontal strains. As the hole diameter increased from 0 to 50 mm, the compression strength and elastic modulus reduced. The decreasing trend slowed down, and the relationships between the hole diameter and compression strength, and elastic modulus could be represented by negative liner functions. The Poisson ratio of the specimen increased in waves with the increase in hole diameter from 0 to 50 mm. A crack in the concrete specimen with 0–20 mm diameter hole started at the upper and lower diagonal angles of the hole wall; a crack in the concrete specimen with 30–50 mm diameter hole started at the left and right parts of the hole wall. The instability mode of concrete specimens with horizontal holes of different diameters was divided into shear dislocation instability and planar splitting instability.
Increased plasma ANGPTL7 levels with increased obstructive sleep apnea severity
Authors: Leentjens M. , Alterki Abdulmohsen , Abu-Farha Mohamed , Bosschieter P. F. N. , de Raaff CAL. , de Vries CEE. , Al Shawaf Eman , Thanaraj Thangavel Alphonse , Al-Khairi Irina , Cherian Preethi , Channanath Arshad , Kavalakatt Sina , van Wagensveld B. A. , de Vries N. , Abubaker Jehad 
Published: August 2022

BackgroundWeight-loss surgery is one of the recommended methods for treating obstructive sleep apnea (OSA) in obese patients. While weight reduction is critical to relieve symptoms of OSA, the biochemical factors involved in post-surgery improvement are still unknown. We aimed to explore the link between ANGPTL7 and OSA in patients with different OSA severity. Furthermore, we examined the effect of treating OSA with bariatric surgery on ANGPTL7 level.MethodsWe quantified levels of circulating ANGPTL7 in fasting plasma and adipose tissue samples of 88 participants before and after bariatric surgery. Confocal microscopy analyses were also performed to assess the ANGPTL7 expression in subcutaneous white adipose tissue biopsies obtained from people with moderate-to-severe OSA compared to those with none or mild OSA. The study involved 57 individuals with none or mild OSA and 31 patients with moderate-to-severe OSA.ResultsLevels of circulating ANGPTL7 were significantly higher in people with moderate-to-severe OSA (1440 ± 1310 pg/ml) compared to the none or mild OSA group (734 ± 904 pg/ml, p = 0.01). The increase in ANGPTL7 correlated significantly and positively with the apnea-hypopnea index (AHI, r = .226, p = .037), and AHI-supine (r = .266, p = .019) in participants with moderate-to-severe OSA. Multivariate logistic regression analysis demonstrated an association between ANGPTL7 and OSA severity (log2 ANGPTL7; OR =1.24, p = 0.024). ANGPTL7 levels exhibited significant positive correlations with the levels of TG and oxLDL (p-value = 0.002 and 0.01 respectively). Bariatric surgery reduced the levels of both ANGPTL7 and AHI significantly.ConclusionHere we report significantly increased levels of ANGPTL7 both in the circulation and in adipose tissue of patients with OSA, which concurred with increased inflammation and OSA severity. Levels of ANGPTL7 decreased significantly as OSA showed a significant improvement post-surgery supporting a potential role for ANGPTL7 in either OSA progression or a role in an OSA-related mechanism.
Influence of dipeptidyl peptidase-4 inhibitors on glycemic variability in patients with type 2 diabetes: A meta-analysis of randomized controlled trials
Authors: Chai Shangyu , Zhang Ruya , Zhang Ye , Carr Richard David , Zheng Yiman , Rajpathak Swapnil , Yu Miao 
Published: August 2022

ObjectiveThe influence of dipeptidyl peptidase-4 (DPP4) inhibitors on glycemic variability compared to other oral antidiabetic drugs (OADs), measured based on the mean amplitude of glycemic excursions (MAGE), has not been comprehensively analyzed. The aim of the study was to perform a meta-analysis to compare the effects of DPP4 inhibitors on MAGE with other OADs in type 2 diabetes mellitus (T2DM) patients without concurrent insulin treatments.MethodsThe Medline (PubMed), Embase (Ovid), and CENTER (Cochrane Library) databases were searched for relevant randomized controlled trials (RCTs). Study characteristics and outcome data were independently extracted by two authors. A random-effect model was used to combine the results.ResultsFourteen studies with 855 patients were included. Compared to other OADs, DPP4 inhibitors significantly reduced MAGE (mean difference [MD]: -0.69 mmol/L, 95% confidence interval [CI]: -0.95 to -0.43, P&lt;0.001) with mild heterogeneity (I2 = 28%). Predefined subgroup analyses suggested that DPP4 inhibitors were more effective in reducing MAGE compared to insulin secretagogues (MD: -0.92 mmol/L, P&lt;0.001) and non-secretagogues (MD: -0.43 mmol/L, P=0.02), as well as compared to sulfonylureas (MD: -0.91 mmol/L, P&lt;0.001) and sodium glucose cotransporter 2 inhibitors (MD: -0.67 mmol/L, P=0.03).ConclusionsDPP4 inhibitors may significantly reduce glycemic variability compared to other oral anti-diabetic drugs, as evidenced by MAGE in T2DM patients with no concurrent insulin treatment.Systematic review registrationINPLASY, registration number: INPLASY2021120113.