bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability of respiratory-gated real-time two-dimensional cine incorporating deep learning reconstruction for the assessment of ventricular function in an adult population
Authors: Orii Makoto , Sone Misato , Osaki Takeshi , Kikuchi Kei , Sugawara Tsuyoshi , Zhu Xucheng , Janich Martin A. , Nozaki Atsushi , Yoshioka Kunihiro 
Published: October 2022

Abstract
This study aimed to assess the image quality and accuracy of respiratory-gated real-time two-dimensional (2D) cine incorporating deep learning reconstruction (DLR) for the quantification of biventricular volumes and function compared with those of the standard reference, that is, breath-hold 2D balanced steady-state free precession (bSSFP) cine, in an adult population. Twenty-four patients (15 men, mean age 50.7 ± 16.5 years) underwent cardiac magnetic resonance for clinical indications, and 2D DLR and bSSFP cine were acquired on the short-axis view. The image quality scores were based on three main criteria: blood-to-myocardial contrast, endocardial edge delineation, and presence of motion artifacts throughout the cardiac cycle. Biventricular end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejection fraction (EF), and left ventricular mass (LVM) were analyzed. The 2D DLR cine had significantly shorter scan time than bSSFP (41.0 ± 11.3 s vs. 327.6 ± 65.8 s; p < 0.0001). Despite an analysis of endocardial edge definition and motion artifacts showed significant impairment using DLR cine compared with bSSFP (p < 0.01), the two sequences demonstrated no significant difference in terms of biventricular EDV, ESV, SV, and EF (p > 0.05). Moreover, the linear regression yielded good agreement between the two techniques (r ≥ 0.76). However, the LVM was underestimated for DLR cine (109.8 ± 34.6 g) compared with that for bSSFP (116.2 ± 40.2 g; p = 0.0291). Respiratory-gated 2D DLR cine is a reliable technique that could be used in the evaluation of biventricular volumes and function in an adult population.
Application of Time Series Analysis to Supplier Selection Problem: A Problem of Multi-Objective Decision Making
Authors: Gupta Srikant , Gupta Neha , Kamal Murshid 
Published: October 2022

Abstract
In today’s competitive environment, markets have made the purchasing function an ever more necessary action in supply chain management while in the same manner the survival of a business, for the most part, depends largely on its supplier’s. An effective and efficient supplier can give a competitive edge to a business. In general, the supplier selection is a multi-objective decision-making problem that involves several quantitative and qualitative factors that helps in minimizing the net ordering cost, minimizing the transportation cost, and minimizing the late deliveries. If we look at the different circumstances of life, we cannot predict anything in advanced. Therefore, we have taken the case of ambiguity in input parameters. Interval type-2 trapezoidal fuzzy numbers have been used to present the ambiguity in the input parameters, and crisp equivalent form has been obtained by taking the expected value. We also have used exponential smoothing forecasting analysis for getting the specific demand for the product to avoid the losses of shortages. Finally, we have used an efficient fuzzy goal programming approach for obtaining the compromise solution. A numerical example has been given to illustrate the concepts of the proposed methodology.
Characterization of the transcriptional responses of Armillaria gallica 012m to GA3
Authors: Cao Yapu , Cai Guolei , Tian Menghua , Mo Haiying , Chen Xin , Li Zhihao , Ji Qiaolin , He Kaixiang , Du Gang , Yang Haiying 
Published: October 2022

Abstract
Gastrodia elata needs to establish a symbiotic relationship with Armillaria strains in order to obtain nutrients and energy. However, the signaling crosstalk between G. elata and Armillaria strains is still unclear. During our experiment, we found that the vegetative mycelium of Armillaria gallica 012m grew significantly better in the media containing gibberellic acid (GA3) than the blank control group (BK). In order to explore the response mechanism, we performed an RNA-sequencing experiment to profile the transcriptome changes of A. gallica 012m cultured in the medium with exogenous GA3. The transcriptome-guided differential expression genes (DEGs) analysis of GA3 and BK showed that a total of 1309 genes were differentially expressed, including 361 upregulated genes and 948 downregulated genes. Some of those DEGs correlated with biological process, including positive regulation of chromosome segregation, mitotic metaphase/anaphase transition, attachment of mitotic spindle microtubules to kinetochore, mitotic cytokinesis, and nuclear division. These analyses explained that GA3 actively promoted the growth of A. gallica to some extent. Further analysis of protein domain features showed that deduced polypeptide contained 49 candidate genes of GA receptor, and 28 of them expressed in our samples. We speculate that GA receptors exist in A. gallica 012m. Comparative studies of proteins showed that the postulated GA receptor domains of A. gallica 012m have a higher homologous correlation with fungi than others based on cluster analysis.
Ester-Functionalised Ferrocene based Polyvinylbenzyl Chloride Nanofibre as a Decyanidating Agent
Authors: Adesoji A. O. , Shotonwa I. O. , Tshentu Z. R. , Adewuyi S. 
Published: October 2022

Abstract
Diazotization-esterification mechanism was employed to synthesize 1-(2-pyridylazo)-2-naphthyl-bis(ƞ5-cyclopentadienyl)ironcarboxylate, FePNCp, [Fe(C5H5)(C5H4CO2C15H10N3)] which was further embedded on synthesized electrospun polyvinylbenzylchloride (ePVBC) to form a functionalized nanofibre composite of poly(ferrocenyl-l-(2-pyridylazo)-2-naphthylvinylbenzylchloride, (FePNCp-PVBC). FePNCp and ePVBC were characterized using spectroscopic (1H NMR, FT-IR, GC/MS, UV-vis) and scanning electronic microscopic techniques. The polymeric solution of PVBC was pumped via a spinneret at a flow rate of 1.2 mL/h with an applied 30 kV for nanofibres collection. The morphology of the functionalized nanofibre showed smooth fibrous and porous assembled structure with average particle size of 19.92 nm. Owing to the intrinsic properties of the newly produced material, it was applied in the entrapping of cyanide ions from an aqueous medium. Using a sorbent dosage of 0.01g in 8 mg/L CN− concentration, 92.2% decyanidation capacity was observed within 45 minutes for FePNCp-PVBC while 65.83% was obtained for the unfunctionalized ePVBC. The obvious improvement recorded by FePNCp-PVBC for the entrapment of CN− ions could be attributed to coordinative interaction between ferrocenyl molecule and cyanide ligand. By comparing with similar nanofibre materials, this new FePNCp-PVBC gave higher performance efficiency, thus could serve as a better alternative to cyanide detoxification.
Low-frequency variability enhancement of the midlatitude climate in an eddy-resolving, coupled ocean-atmosphere model. Part II: Mechanisms
Authors: Kurashina Ryosuke , Berloff Pavel 
Published: October 2022

Abstract
This paper investigates the spatial inhomogeneity of the time-averaged, quasigeostrophic, double-gyre circulation response to fixed, realistic, large-scale modes of wind-stress forcing. While the companion paper of this study focused on understanding the anatomy of the low-frequency midlatitude climate variability in the coupled configuration of the same model, this paper looked at understanding the nature of the wind-induced ocean gyre response in an ocean-only configuration of the same model. Our analysis revealed two time-averaged responses to an east-west dipole wind-stress curl anomaly in the ocean basin. Firstly, wind-stress anomalies in the western ocean basin led to changes in relative strength of the inertial recirculation zones and jet-axis tilt which is consistent with an advection-dominated, nonlinear adjustment of the ocean gyres to anomalous forcing. Secondly, wind-stress curl anomalies in the eastern ocean basin was found to induce a largely independent response involving meridional shifts of the eastward jet extension. The effects of time-averaged advection in this region were weak and the discovery of westward-propagating Rossby waves along the eastward jet revealed the response is more akin to a baroclinic Rossby wave adjustment.
Long-term outcomes of nasopharyngeal carcinoma by Epstein-Barr virus status in the Chinese population: a multicenter investigation
Authors: Xiong Yudi , Yuan Mengting , Liu Zhigang , Huang Jing , Bi Jianping , Pi Guoliang , Li Ying , Li Yanping , He Hanping , Verma Vivek , Tian Suqing , Han Guang 
Published: October 2022

Abstract
Background
Because the vast majority of nasopharyngeal carcinoma (NPC) in Chinese patients is a direct result of Epstein–Barr virus (EBV) infection, there is a dearth of data for EBV-negative patients in this population. This multicenter study sought to examine the clinical characteristics of this population and compare long-term outcomes with a propensity-matched (1:1.5) EBV-positive cohort.
Methods
NPC patients with known EBV status from four hospitals were collated (2013–2021). A logistic regression model was conducted to evaluate the relationship between patient characteristics and EBV status. The Kaplan–Meier method and Cox regression analysis were used to analyze survival data.
Results
This study analyzed 48 (40%) EBV-negative and 72(60%)EBV-positive patients. The median follow-up time was 63.5 months. Most EBV-negative NPC patients (77.1%) were diagnosed in the advanced stages, and no significant prognostic factors were discerned in this subpopulation. EBV-negative disease was more associated with the keratinizing subtype (18.8% vs. 1.4%, P < 0.05), whereas nearly all EBV-positive cases were non-keratinizing. Compared to EBV-negative NPC patients, EBV-positive NPC patients were more likely to develop local recurrence (9.7% vs. 0%, P = 0.026). There was no statistical difference in mortality (8.3% vs. 4.2%, P = 0.34) during the follow-up period.
Conclusions
These multicenter data suggest that in the Chinese population, EBV-negative disease have similar survival outcomes as EBV-positive cases, despite the increased local recurrence in the latter. Further work is required to corroborate these conclusions.
Trial registration:
retrospectively registered (Permit Number: LLHBCH2022YN-037). This retrospective study followed the principles of the Helsinki Declaration and was approved by the Ethics Committee of Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China.
A rapid plant regeneration system by using stem and leaf explants of Olea europea L. cv. Koroneiki; a multipurpose bioenergy tree
Authors: Khalid Laraib , Jamil Iqra , Sajid Zahoor Ahmad , Aftab Faheem 
Published: October 2022

Abstract
Olea europea L. cv. koroneiki is a multipurpose tree which belongs to family Oleaceae. Koroneiki is famous for its virgin oil production and suitable for high density growing system around the world. Being grafted and recalcitrant in nature, Koroneiki demands an efficient in vitro protocol for its propagation and conservation. The aim of the present study was to set up an efficient protocol for in vitro regeneration of this beneficial olive cultivar. Three different basal media, Murashige and Skoog (MS), Olive Medium (OM) and Woody Plant Medium (WPM) were tested for two types of explants, leaf and nodal segments for callus induction and shoot regeneration. To find out the best explant disinfestation method during this study, explants were soaked in detergent for 15 minutes with continuous agitation. After washing, explants were rinsed with 70% ethanol for 10 seconds and finally treated with 0.1% mercuric chloride for 3 minutes and rinsed 4–5 times with autoclaved distilled water under the laminar air flow cabinet considered as most suitable for cv. Koroneiki. Media were either used alone or supplemented with 6-benzylaminopurine (BAP) (8.8 and 17.7 µM) and zeatin (4.56 and 9.12 µM) to find out suitable PGR for callus induction and shoot proliferation. Maximum callus induction (70%) on nodal explants was observed on OM medium containing 9.12 µM zeatin + 17.7 µM BAP under both dark and light conditions. The WPM containing the combination of BAP and zeatin showed 67% callus induction under light by using nodal explants. However, in case of leaf explants, 50% callus induction response was observed under dark conditions, but no callus was observed under light. The OM supplemented with combination of BAP (17.7 µM) and zeatin (9.12 µM) induced highest shoot length (1.5) and maximum number of leaves (3.5). This study might helpful for commercial propagation of cv. Koroneiki at mass scale under in vitro conditions to fulfill the virgin oil demand for rapidly growing population.
Online interventions and virtual day centres for young people who use drugs – potential for harm reduction?
Authors: Sande Matej , Dekleva Bojan , Razpotnik Špela , Tadič Darja , Rozman Mija Marija Klemenčič , Pavel Jana Rapuš 
Published: October 2022

Abstract
Background
The methodological part of the large-scale study on the psychosocial distress of young people in Slovenia focused on vulnerable young people who use drugs and explored the potential of online interventions in harm reduction programmes. We looked at the needs of young people who, at the time of the research, were attending a virtual Discord day centre hosted by the DrogArt NGO or were involved in the organisation's other programmes. We explored young people's knowledge of online interventions, their satisfaction with them, and the opportunities they offer for harm reduction programmes.
Methods
The study used a qualitative methodology with a combination of deductive and inductive coding, and relied on framework analysis. 18 young people who had used drugs or had stopped using participated in the study. The inclusion criterion was a minimum age of 25 years. In-depth interviews were conducted with the young people, which lasted on average between one and a half and two hours.
Results
The study showed the potential of online interventions, specifically the virtual day centre, which provide a safe and relaxed space for young people in the sample to meet and talk, which is accessible and where they feel welcome. Online interventions have also enabled some of the sample to engage in the "offline" support types offered within the organisation. The main advantages of online interventions are seen by young people as being more "geographically" accessible and more available during the COVID-19 epidemic. Online support suits some people because they can leave sessions more quickly and it is more informal, while others prefer it because of specific problems or difficulties, such as social anxiety.
Conclusions
The results show the relatively high potential of online interventions in harm reduction programmes, as well as more broadly for young people with various psychosocial difficulties and who, for example, do not use drugs. These types of support allow quick contact with a professional or peer and facilitate contact with a support programme. Young people are still poorly informed about the support programmes available in Slovenia and would like more information. Thus, in addition to developing and upgrading the network of programmes, we need to focus on providing information to young people through channels that are close to them and can reach them.
A pan-cancer analysis of the oncogenic role of ribonucleotide reductase subunit M2 in human tumors
Authors: Wang Yong , Chen Rong , Zhang Jing , Zeng Peng 
Published: October 2022

Abstract
Although there is evidence that ribonucleotide reductase subunit M2 (RRM2) is associated with many cancers, no pan-cancer analysis is available. This study aims to explore the potential oncogenic role of RRM2 in pan-cancer based on the datasets of TCGA (The cancer genome atlas). RRM2 was highly expressed in most cancers and obvious correlation existed between RRM2 expression and prognosis of tumor patients. RRM2 expression was associated with infiltration level of diverse immune cell as well as endothelial cells, immune checkpoint, tumor mutational burden (TMB) and microsatellite instability (MSI). Moreover, the cell cycle pathway was involved in the functional mechanisms of RRM2. Our pan-cancer study provides a fairly comprehensive understanding of the oncogenic roles of RRM2 across different tumors.
Meiotic abnormalities in sugarcane (Saccharum spp.): Evidence for peri- and paracentric inversions
Authors: Oliveira Gleicy Kelly , Soares Nina Reis , Costa Zirlane Portugal , Almeida Carmelice Boff , Machado Raquel Moura , Mesquita Amanda Teixeira , Carneiro Monalisa Sampaio , Forni-Martins Eliana R. , Mondim Mateus , Vieira Maria Lucia Carneiro 
Published: October 2022

Abstract

The modern cultivars of sugarcane (Saccharum spp.) are highly polyploid and accumulate aneuploidies due to their history of domestication, genetic improvement and interspecific hybrid origin involving the domesticated sweet species S. officinarum ('noble cane') and the wild S. spontaneum, both with an evolutionary history of polyploidy. The first hybrids were backcrossed with S. officinarum, and selection from progenies in subsequent generations established the genetic basis of modern cultivars. Saccharum genome complexity has inspired several molecular studies that have elucidated aspects of sugarcane genome constitution, architecture and cytogenetics. Herein, we conducted a comparative analysis of the meiotic behavior of representatives of the parentals S. officinarum and S. spontaneum, and the commercial variety, SP80-3280. S. officinarum, an octoploid species, exhibited regular meiotic behavior. In contrast, S. spontaneum and SP80-3280 exhibited several abnormalities from metaphase I to the end of division. We reported and typified, for the first time, the occurrence of peri- and paracentric inversions. Using in-situ hybridization techniques, we were able to determine how pairing association occurred at diakinesis and, in particular, the chromosome composition of SP80-3280. Our findings have implications for sugarcane genetic mapping, genomics, and for studies on resynthesized polyploids.
Impact of Deccan Volcanism on Reorganization of the Indian plate kinematics
Authors: Bhagat Amarjeet Ramesh , Sangode S. J. , Dongre Ashish 
Published: October 2022

Abstract
Western Indian Ocean basin shows one of the most complex signatures of the ocean floor anomalies by juxtaposition of the rapidly evolving, multiple spreading ridges, subduction systems and microcontinental slivers. This study based on ocean floor magnetic anomalies, gravity gradient map, tomographic profiles and geometrical kinematic models reports a significant westward drift of the Central Indian Ridge (CIR) segments. Documented precisely between the latitudes 17°S and 21°S the drift is coincident with the Deccan volcanism at ~ 65 ± 2 Ma and we further explain its bearing on the Indian plate kinematics. The progressive stair-step trend of the ridge segments towards NE is marked by anomalous deflection to NW for a brief distance of ~ 217 km between these latitudes represented by the anomalies C30n-C29n. The observed length of the ridge segments moving NW at 17°S match the calculated NW drift rates of Indian plate (Bhagat et al., 2022). We infer that the NW drift and its restoration towards NE triggered short Plume Induced Subduction Initiation along the Amirante trench. Further a plume induced lithospheric tilt of the Indian plate (Sangode et al 2022) led to restoration of subduction along the Sunda trench at ~ 65 Ma imparting new slab pull force over the Indian subcontinent besides the NE trend for CIR. This episode resulted into anticlockwise rotation of the Indian plate along with accelerated drift rates due to vector addition of the plume push and the slab pull forces from Eurasian as well as Sunda subduction systems after 65 Ma. The Deccan eruption thus resulted in major geodynamic reorganization that altered the kinematics of Indian plate; and the signatures of which are well preserved over the ocean floor.
In silico bioprospecting of receptors for Doderlin: an antimicrobial peptide isolated from Lactobacillus acidophilus
Authors: Seif Elias Jorge Muniz , Icimoto Marcelo Yudi , Junior Pedro Ismael da Silva 
Published: October 2022

Abstract

Background
The emergence of resistant bacterial strains against traditional antibiotics and treatments increases each year. Doderlin is a cationic and amphiphilic peptide active against gram-positive, gram-negative and yeast stains. The aim of the present work was to identify potential receptors associated with the antimicrobial activity of Doderlin using in silico bioinformatics tools.
Methods
To search for potential targets of Doderlin, PharmMapper software was used. Molecular docking between Doderlin and the receptor was performed by PatchDock. Additional interaction and ligand site prediction for each receptor was performed by I-TASSER software.
Results
Those PDB, 1XDJ (11746), 1JMH (11046), 1YR3 (10578), and 1NG3 (10082), showed the highest dock score. Doderlin was found to be predicted/co-localized with A and B, enzymes accountable for nitrogenic bases.
Conclusion
The resulting receptor bioprospecting is highly correlated and suggests that Doderlin might act by interfering with DNA metabolism/production of bacteria, altering microorganism homeostasis and growth impairment.
Association between PTPN1 polymorphisms and obesity-related phenotypes in European adolescents: influence of physical activity
Authors: Salazar-Tortosa Diego F. , Labayen Idoia , González-Gross Marcela , Seral-Cortes Miguel , Moreno Luis A. , Zapico Augusto G. , Widhalm Kurt , Meirhaeghe Aline , Enard David , Ruiz Jonatan R 
Published: October 2022

Abstract

Background To study the associations ofProtein Tyrosine Phosphatase-N1(PTPN1) polymorphisms with obesity-related phenotypes in European adolescents, and the influence of physical activity on these relationships. Methods Five polymorphisms ofPTPN1were genotyped in 1,057 European adolescents (12–18 years old). We measured several phenotypes related to obesity, such as adiposity markers, and biochemical and clinical parameters. Physical activity was objectively measured by accelerometry. Results The T, A, T, T and G alleles of the rs6067472, rs10485614, rs2143511, rs6020608 and rs968701 polymorphisms, respectively, were associated with lower levels of obesity-related phenotypes (i.e., body mass index, body fat percentage, hip circumference, fat mass index, systolic blood pressure and leptin) in European adolescents. In addition, the TATTG haplotype was associated with lower body fat percentage and fat mass index compared to the AACCA haplotype. Finally, when physical activity levels were considered, alleles of the rs6067472, rs2143511, rs6020608 and rs968701 polymorphisms were only associated with lower adiposity in active adolescents. ConclusionsPTPN1polymorphisms were associated with adiposity in European adolescents. Specifically, alleles of these polymorphisms were associated with lower adiposity only in physically active adolescents. Therefore, meeting the recommendations of daily physical activity may reduce obesity risk by modulating the genetic predisposition to obesity.