bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of Catalase Enzyme from Leaf Tissue of Aronia (Aronia melanocarpa) Plant
Authors: Taş Ömer , Mitrovica Betül , Ekinci Deniz 
Published: November 2022

Abstract
Aronia is among the most antioxidant containing plants which is found commonly around the worls. Aronia cultivation started in Turkey for the first time in 2012 at the Atatürk Central Research Institute of Garden Cultures, and a plantation was constructed in the experimental area. Since antioxidants help to preserve food by blocking oxidation processes and contributing to the health promotion provided by numerous dietary supplements, nutraceutical and functional food additives, antioxidant capacity of these plants should be well characterized. To assess and evaluate the antioxidant content of foods and plant products, many approaches are utilized. In this study, catalase enzyme was partially purified from aronia plant leaf tissue and characterization was carried out. Purification process consisted of homogenate preparation, ammonium sulfate precipitation and dialysis. The optimal ionic strength, pH, substrate concentration and enzyme quantity were examined. These values were found to be 300 mM TRIS, pH:8, 12 mM H2O2 and 75 µl, respectively, for the catalase enzyme of the Aronia plant leaf tissue. This study is the first in the literature dealing with the characterization of antioxidant enzyme from Aronia plant.
CXCL family-related classification predicts prognosis and response to immunotherapy in patients with head and neck squamous cell carcinoma
Authors: Gao Shun , Tang Xuemei , Gao Chao , Gao Xinrui , Guo Xuanzhu , Luo Yuyao , Li Sijie , Gong Guotao , Zhang Yan , Lin Sheng 
Published: November 2022

Abstract
Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent malignant cancer worldwide. The cysteine X cysteine (CXC) chemokine family contains 17 members. Increasing evidence supports that CXC chemokines are crucial for the growth, invasion, metastasis, and microenvironment of tumour cells. Although the precise functions of CXC ligands (CXCLs) in HNSCC are unclear, these proteins are considered to play important roles in controlling tumour growth and forming the tumour immune environment.
Results: We identified two subtypes of HNSCC associated with the CXCL family through consensus clustering, named as clusters 1 and 2. Patients with the cluster 1 subtype showed favourable clinical outcomes, considerable immune cell infiltration, and improved immune response signalling pathway modulation. We developed a nomogram of CXCL family scores for therapeutic use and CXCL family scores to predict the overall survival of patients with HNSCC. Patients with lower CXCL family scores showed longer overall survival and higher immune cell infiltration in their tissues.
Conclusion: We developed a new classification method for HNSCC using the CXCL family genes. This method can be used clinically to evaluate the prognosis and response to immunotherapy in patients with HNSCC.
Vaginal health and quality of sexual life of postmenopausal women on hyaluronic acid and Biosaccharide Gum-1 vaginal gel
Authors: Caruso Salvatore , Pasqua Salvatore Di , Bambili Elisa , Palermo Gaia , Mazza Gabriele , Caruso Giuseppe 
Published: November 2022

Abstract
Background: To evaluate the efficacy of daily vaginal gel containing hyaluronic acid (HA) and Biosaccharide Gum-1 (BG-1) on vulvovaginal atrophy (VVA) and on sexual function and quality of life (QoL).
Methods: One hundred-four postmenopausal women with VVA were enrolled in the nonrandomized comparison cohort study. Of them, 50 women on HA/BG-1 participated in the study group and 54 women on lubricants/moisturizers on-demand as a control group.
The primary endpoint was the efficacy of the vaginal gel on VVA evaluated by the Vaginal Health Index (VHI) score. Secondary endpoints included sexual behavior by the self-administered female sexual function index (FSFI) questionnaire and quality of life (QoL) by the Short Form-36 questionnaire (SF-36).
Results: All symptoms of AVV improved after 12 weeks of treatment in women on HA/BG-1. The VMI, although improved at the 12-week follow-up compared to baseline, indicated a low estrogenic stimulation value. Sexual function improved significantly in women on HA/BG-1. Moreover, women reported a significant improvement in the somatic aspects of QoL. No benefits were obtained by the women in the study group.
Conclusions: Treatment with HA/BG-1 could be used in postmenopausal women who complain of vaginal dryness. The amelioration of VVA-related signs could improve sexual function and QoL.
Innovative technology to solve the problems of automation of mining and geological works
Authors: Kaimov Aidarkhan , Aimbetov Nurzhan , Saurova Zarina 
Published: November 2022

The object of research relates to the field of control systems for mining and transportation machinery in the development of solid mineral deposits in open-cut mining. The problem of reducing the cost of transporting 1 ton of rock mass and increasing the efficiency of these machines is solved. The article develops an expert system for the disposition of mining vehicles with a subsystem for the selection of their innovative appearance with the ability to control their operating parameters, taking into account the stochastic conditions of the developed sections of the rock. The mathematical model for the construction of the future appearance of a mining and transportation machine, based on its functional and economic evaluation, reduces to the solution of the problem of optimization of the generalized criterion of required efficiency. As an example of private indicators of their effectiveness in operation, there is an expert analysis of the evaluation of options for solutions, for example, structural-kinematic and operational parameters of these machines, etc. Innovative designs of a trough body of any size of the carrying capacity of single-rope and multi-rope steep elevators for highly profitable mining in quarries are justified unlimited values of their depth and annual productivity. In the proposed study, the values of the resistance forces to the destruction of a section of a rock mass, determined by analytical and experimental methods, are refined by finding the optimal Kalman coefficient, which increases the efficiency of the use of mining and transport machines. The proposed methods allow the development of innovative mining and transport machines with the ability to control their operating parameters taking into account the stochastic conditions of the mined rock section
Nascent Nanoformulations as an Insight into the Limitations of the
Conventional Systemic Antifungal Therapies
Authors: Jain Subheet Kumar , Kaur Manjot , Shivgotra Riya , Bhardwaj Nitish , Saini Shagun , Thakur Shubham 
Published: November 2022

Abstract:
More than 150 million people have significant fungal diseases that greatly impact health care and economic expenditures. The expansion of systemic fungal infections and invasive mycoses is being driven by an increase in the number of immunocompromised patients and the recent COVID-19 patients, especially severely ill. There have been numerous cases of fungal infections linked to COVID-19, with pulmonary aspergillosis dominating at first but with the subsequent ap-pearance of mucormycosis, candidiasis, and endemic mycoses. Candida spp. is the most frequent pathogen, with approximately 1 billion infections yearly, among other species causing the most prevalent invasive fungal infections. The importance of recognizing the epidemiological shifts of invasive fungal infections in patient care cannot be overstated. Despite the enormous antifungal therapies available, these infections are difficult to diagnose and cause high morbidity and mortality rates. Treatment choices for systemic fungal infections are severely limited due to the limitations of conventional therapy effectiveness and drug toxicities. So the researchers are still looking for novel therapeutic options, such as carrier-based approaches that are convenient and cost-effective with high and long-lasting fungal infection cure rates with reduced toxicities. The focus of this study is on summarizing the nanotechnology, immunotherapy methods and the drugs under clinical trials that have been employed in treatment as carrier-based antifungal formulations. Most of these have been reported to be promising strategies with broad-spectrum antifungal action and the potential to overcome antibiotic resistance mechanisms. We speculate that this review summarized the current knowledge to its best that will help the future developments of new antifungal therapies.
Current Drug Delivery Strategies for Buccal Cavity Ailments using Mouth
Dissolving Wafer Technology: A Comprehensive Review on the Present
State of the Art
Authors: Jana Bani Kumar , Singh Mohini , Dutta Rajat Subhra , Mazumder Bhaskar 
Published: November 2022

Background:
Mouth-dissolving wafer is polymer-based matrice that incorporates various
pharmaceutical agents for oral drug delivery. This polymeric wafer is ingenious in the way that it needs
not be administered with water, like in conventional tablet dosage form. It has better compliance among
the pediatric and geriatric groups owing to its ease of administration.

Objective:
The polymeric wafer dissolves quickly in the oral cavity and is highly effective for a targeted
local effect in buccal-specific ailments. It is a safe, effective, and versatile drug delivery carrier for a
range of drugs used to treat a plethora of oral cavity-specific ailments that inflict common people, like
thrush, canker sores, periodontal disease, benign oral cavity tumors, buccal neoplasm, and malignancies.
This review paper focuses thoroughly on the present state of the art in mouth-dissolving wafer
technology for buccal drug delivery and targeting. Moreover, we have also addressed present-time limitations
associated with wafer technology to aid researchers in future developments in the arena of buccal
drug delivery.

Conclusion:
This dynamic novel formulation has tremendous future implications for designing drug
delivery systems to target pernicious ailments and diseases specific to the buccal mucosa. In a nutshell,
this review paper aims to summarize the present state of the art in buccal targeted drug delivery.
Ultramicronized N-palmitoylethanolamine Contributes to Morphine
Efficacy Against Neuropathic Pain: Implication of Mast Cells and Glia
Authors: Micheli Laura , Lucarini Elena , Nobili Stefania , Bartolucci Gianluca , Pallecchi Marco , Toti Alessandra , Ferrara Valentina , Ciampi Clara , Ghelardini Carla , Di Cesare Mannelli Lorenzo 
Published: November 2022

Background::
In the current management of neuropathic pain, in addition to antidepressants
and anticonvulsants, the use of opioids is wide, despite their related and well-known issues.

Objective::
N-palmitoylethanolamine (PEA), a natural fatty-acid ethanolamide whose anti-inflammatory,
neuroprotective, immune-modulating and anti-hyperalgesic activities are known, represents a promising
candidate to modulate and/or potentiate the action of opioids.

Methods::
This study was designed to evaluate if the preemptive and morphine concomitant administration
of ultramicronized PEA, according to fixed or increasing doses of both compounds, delays
the onset of morphine tolerance and improves its analgesic efficacy in the chronic constriction injury
(CCI) model of neuropathic pain in rats.

Results::
Behavioral experiments showed that the preemptive and co-administration of ultramicronized
PEA significantly decreased the effective dose of morphine and delayed the onset of morphine tolerance.
The activation of spinal microglia and astrocytes, commonly occurring both on opioid treatment and neuropathic
pain, was investigated through GFAP and Iba-1 immunofluorescence. Both biomarkers were
found to be increased in CCI untreated or morphine treated animals in a PEA-sensitive manner. The increased
density of endoneural mast cells within the sciatic nerve of morphine-treated and untreated CCI
rats was significantly reduced by ultramicronized PEA. The decrease of mast cell degranulation, evaluated
in terms of reduced plasma levels of histamine and N-methyl-histamine metabolite, was mainly
observed at intermediate-high doses of ultramicronized PEA, with or without morphine.

Conclusion::
Overall, these results show that the administration of ultramicronized PEA in CCI rats
according to the study design fully fulfilled the hypotheses of this study.
Pharmacological and Pathological Relevance of S100 Proteins in Neurological Disorders
Authors: Goswami Deepali , Anuradha Urati , Angati Anok , Kumari Nisha , Singh Rakesh Kumar 
Published: November 2022

Abstract:The S100 protein is one of the calcium-binding proteins associated with Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. S100 proteins are expressed in the central nervous system by oligodendrocytes, astrocytes and neurons during both normal and disease conditions. Although amyloid-beta aggregation and hyperphosphorylated tau plaques are the main pathological hallmarks of Alzheimer’s disease, the S100 protein family is closely associated with neuroinflammation in several neurodegenerative disorders, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis in addition to various types of cancer and other brain diseases. This review aims to present the key role of S100 proteins and their different relevant isoforms, along with the various approaches used for the regulation of these proteins in several neurodegenerative disorders.
Examining the Influence of Self-compassion Education and Training Upon Parents and Families When Caring for their Children: A Systematic Review
Authors: Othman Shwikar , Steen Mary , Wepa Dianne , McKellar Lois 
Published: November 2022

Background:
It is well-recognized that early parenting significantly influences the health and well-being of children. However, many parents struggle with the daily demands of being a parent and feel overwhelmed and exhausted psychologically and physically. Encouraging self-care practices is essential for parents, and self-compassion may be a potential strategy to utilize.

Objectives:
The review aims to assess the influence and impact of providing self-compassion education for parents and families when caring for their children.

Methods:
This systematic review utilized Joanna Briggs Institute (JBI) methodology. A three-stage search approach was undertaken that included seven electronic databases, registries and websites. These databases are Medline, Embase, PsycINFO, Emcare, Cochrane library, Scopus, and ProQuest. The included studies were appraised using the standardized critical appraisal instruments for evidence of effectiveness developed by JBI.

Results:
Ten studies met the inclusion criteria. Overall, the studies confirmed improved psychological well-being, and higher levels of self-compassion, kindness towards oneself and others, and mindfulness were reported. In addition, there were improvements in psychological well-being, decreased parental distress and perceived distress, lower levels of anxiety, and avoidance of negative experiences.

Conclusion:
The findings provide evidence to guide further research on developing, designing, facilitating, and evaluating self-compassion education programs and workshops for parents and families.

PROSPERO registration
This systematic review title is registered at the International Prospective Register of Systematic Reviews: CRD42021225021.
Advantages of a Training Course for Surgical Planning in Virtual Reality for Oral and Maxillofacial Surgery: Crossover Study
Authors: Ulbrich Max , Van den Bosch Vincent , Bönsch Andrea , Gruber Lennart Johannes , Ooms Mark , Melchior Claire , Motmaen Ila , Wilpert Caroline , Rashad Ashkan , Kuhlen Torsten Wolfgang , Hölzle Frank , Puladi Behrus 
Published: November 2022

Background
As an integral part of computer-assisted surgery, virtual surgical planning (VSP) leads to significantly better surgery results, such as for oral and maxillofacial reconstruction with microvascular grafts of the fibula or iliac crest. It is performed on a 2D computer desktop screen (DS) based on preoperative medical imaging. However, in this environment, VSP is associated with shortcomings, such as a time-consuming planning process and the requirement of a learning process. Therefore, a virtual reality (VR)–based VSP application has great potential to reduce or even overcome these shortcomings due to the benefits of visuospatial vision, bimanual interaction, and full immersion. However, the efficacy of such a VR environment has not yet been investigated.

Objective
This study aimed to demonstrate the possible advantages of a VR environment through a substep of VSP, specifically the segmentation of the fibula (calf bone) and os coxae (hip bone), by conducting a training course in both DS and VR environments and comparing the results.

Methods
During the training course, 6 novices were taught how to use a software application in a DS environment (3D Slicer) and in a VR environment (Elucis) for the segmentation of the fibula and os coxae, and they were asked to carry out the maneuvers as accurately and quickly as possible. Overall, 13 fibula and 13 os coxae were segmented for each participant in both methods (VR and DS), resulting in 156 different models (78 fibula and 78 os coxae) per method (VR and DS) and 312 models in total. The individual learning processes in both environments were compared using objective criteria (time and segmentation performance) and self-reported questionnaires. The models resulting from the segmentation were compared mathematically (Hausdorff distance and Dice coefficient) and evaluated by 2 experienced radiologists in a blinded manner.

Results
A much faster learning curve was observed for the VR environment than the DS environment (β=.86 vs β=.25). This nearly doubled the segmentation speed (cm3/min) by the end of training, leading to a shorter time (P<.001) to reach a qualitative result. However, there was no qualitative difference between the models for VR and DS (P=.99). The VR environment was perceived by participants as more intuitive and less exhausting, and was favored over the DS environment.

Conclusions
The more rapid learning process and the ability to work faster in the VR environment could save time and reduce the VSP workload, providing certain advantages over the DS environment.
Big Data and Infectious Disease Epidemiology: Bibliometric Analysis and Research Agenda
Authors: Amusa Lateef Babatunde , Twinomurinzi Hossana , Phalane Edith , Phaswana-Mafuya Refilwe Nancy 
Published: November 2022

Background
Infectious diseases represent a major challenge for health systems worldwide. With the recent global pandemic of COVID-19, the need to research strategies to treat these health problems has become even more pressing. Although the literature on big data and data science in health has grown rapidly, few studies have synthesized these individual studies, and none has identified the utility of big data in infectious disease surveillance and modeling.

Objective
The aim of this study was to synthesize research and identify hotspots of big data in infectious disease epidemiology.

Methods
Bibliometric data from 3054 documents that satisfied the inclusion criteria retrieved from the Web of Science database over 22 years (2000-2022) were analyzed and reviewed. The search retrieval occurred on October 17, 2022. Bibliometric analysis was performed to illustrate the relationships between research constituents, topics, and key terms in the retrieved documents.

Results
The bibliometric analysis revealed internet searches and social media as the most utilized big data sources for infectious disease surveillance or modeling. The analysis also placed US and Chinese institutions as leaders in this research area. Disease monitoring and surveillance, utility of electronic health (or medical) records, methodology framework for infodemiology tools, and machine/deep learning were identified as the core research themes.

Conclusions
Proposals for future studies are made based on these findings. This study will provide health care informatics scholars with a comprehensive understanding of big data research in infectious disease epidemiology.
KOMUNIKASI ORANG TUA DAN ANAK DALAM MENCEGAH KECANDUAN GADGET
Authors: Fitri Siti Maghfirah 
Published: November 2022

The growth of information technology provides various influences in human life, both positive and negative influences. The negative influence of technological developments will cause problems in human life. Among these negative impacts is gadget addiction for children. Parents must play an active role in limiting and protecting children from addiction. One way that parents can do is through a communication approach to children. This study aims to find out how communication between parents and children prevents gadget addiction. The research method uses a qualitative approach with a phenomenological study with research subjects being informants who have children aged 12-15 years. The theory in this research is the Dialogue theory from Martin Burber. The results of this study are that of the three families studied using dialogue as a form of communication within the family to prevent gadget addiction for children. these parents consider dialogue to be more effective than other forms of communication. The obstacles that occur in children are that at the beginning of the dialogue it is not easy to give understanding to children to limit gadgets, and children tend to be silent when having dialogue.Keywords: Comunication, preventing, gadget, Dialogue, Parents
Fast Curing with High-power Curing Lights Affects Depth of Cure and Post-gel Shrinkage and Increases Temperature in Bulk-fill Composites
Authors: Odum NC , Ross JT , Citrin NS , Tantbirojn D , Versluis A 
Published: November 2022

SUMMARY

Objectives
High-power LED curing lights and bulk-fill resin composites are intended to reduce chair time. This study investigated depth of cure, post-gel shrinkage (responsible for shrinkage stress), and heat generation in bulk-fill composites when cured according to minimum curing times recommended by manufacturers of curing lights and composites.

Methods
A regular LED curing light (Demi Ultra, 1350 mW/cm2, Kerr Dental) and two LED curing lights with high-power modes (VALO Grand, 3117 mW/cm2 Xtra Power, Ultradent; and Bluephase PowerCure, 2435 mW/cm2 Turbo and 3344 mW/cm2 3sCure, Ivoclar Vivadent) were tested on three bulk-fill composites (Filtek One Bulk Fill, 3M Oral Care Solutions; Tetric EvoCeram Bulk Fill, Ivoclar Vivadent; Tetric Powerfill, Ivoclar Vivadent). Using minimum times recommended by manufacturers (3, 5, 6, 10, or 20 seconds), depth of cure was determined by Vickers hardness of specimens cured in a slot (n=10). Post-gel polymerization shrinkage was measured using a strain gauge (n=10) and temperature with a thermocouple (n=5). Results were analyzed using two- and one-way analysis of variance (ANOVA) followed by pairwise comparisons or Student-Newman-Keuls post hoc tests (α=0.05).

Results
Curing lights and curing protocols significantly affected depth of cure, post-gel shrinkage, and temperature rise (p&lt;0.001). Cure decreased with depth whereby best overall curing performance was achieved by the 20 second exposure at lowest irradiance (Demi Ultra). Fast curing (3–5 seconds) at high irradiance resulted in lesser depth-of-cure performance, except for the BluePhase-Tetric PowerFill combination. Post-gel shrinkage was higher in all composites when cured at high irradiance (p&lt;0.001), while heat generated also tended to be higher.

Conclusions
Although the high-power LED curing lights advertise time savings, not all manufacturer recommended minimum curing times cured bulk-fill materials to the same extent. Moreover, these time savings came at a cost of higher post-gel shrinkage and generated more heat in the bulk-fill composites than the lower irradiance curing protocol.