bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fibrotic remodeling and tissue regeneration mechanisms define the therapeutic potential of human muscular progenitors
Authors: Hsiao Ya‐Chuan , Wang I‐Han , Yang Tsung‐Lin 
Published: November 2022

AbstractFibrosis is an intrinsic biological reaction toward the challenges of tissue injury that is implicated in the wound‐healing process. Although it is useful to efficiently mitigate the damage, progression of fibrosis is responsible for the morbidity and mortality occurring in a variety of diseases. Because of lacking effective treatments, there is an emerging need for exploring antifibrotic strategies. Cell therapy based on stem/progenitor cells is regarded as a promising approach for treating fibrotic diseases. Appropriate selection of cellular sources is required for beneficial results. Muscle precursor cells (MPCs) are specialized progenitors harvested from skeletal muscle for conducting muscle regeneration. Whether they are also effective in regulating fibrosis has seldom been explored and merits further investigation. MPCs were successfully harvested from all human samples regardless of demographic backgrounds. The extracellular matrices remodeling was enhanced through the paracrine effects mediated by MPCs. The suppression effects on fibrosis were confirmed in vivo when MPCs were transplanted into the diseased animals with oral submucous fibrosis. The data shown here revealed the potential of MPCs to be employed to simultaneously regulate both processes of fibrosis and tissue regeneration, supporting them as the promising cell candidates for development of the cell therapy for antifibrosis and tissue regeneration.
Melanoma awareness and prevention among latinx and non‐latinx white adults in urban and rural California: A qualitative exploration
Authors: Mesia Rachel J. , Espinosa Patricia Rodriguez , Hutchison Hayden , Safaeinili Nadia , Finster Laurel J. , Muralidharan Vijaytha , Glenn Beth A. , Haile Robert W. , Rosas Lisa Goldman , Swetter Susan M. 
Published: November 2022

AbstractBackgroundMelanoma mortality rates in the US are highest among older men, individuals of lower socioeconomic status (SES), and people of color. To better understand these inequities, a qualitative exploratory study was conducted in Northern and Southern California to generate knowledge about barriers and facilitators of awareness, prevention, and early detection of melanoma in lower SES Latinx and non‐Latinx White (NLW) individuals living in urban and semi‐rural areas.MethodsNineteen focus groups were conducted (N = 176 adult participants), stratified by race/ethnicity (Latinx, low‐income NLW), geography (semi‐rural, urban), and language (English and Spanish). Inductive and deductive thematic analysis was conducted, and the findings were organized using the socioecological model framework: individual, interpersonal, community, and health system/policy levels.ResultsFour socioecological themes describe how key factors affect knowledge, perceived risk, preventive behaviors, and melanoma screening. Individual level findings revealed that many participants were not familiar with melanoma, yet were willing to learn through trusted sources. Having brown or darker skin tone was perceived as being associated with lower risk for skin cancer. Interpersonally, social relationships were important influences for skin cancer prevention practice. However, for several Latinx and semi‐rural participants, conversations about melanoma prevention did not occur with family and peers. At the community level, semi‐rural participants reported distance or lack of transportation to a clinic as challenges for accessing dermatology care. Healthcare systems barriers included burdens of additional healthcare costs for dermatology visits and obtaining referral.ConclusionsVarying factors influence the awareness levels, beliefs, and behaviors associated with knowledge, prevention, and early detection of melanoma among low‐income Latinx and NLW individuals and in semi‐rural areas. Results have implications for health education interventions. Navigation strategies that target individuals, families, and health care settings can promote improved prevention and early detection of melanoma in these communities.
Patterns of use of biological and genetic markers for chronic lymphocytic leukemia and acute myeloid leukemia in Puerto Rico
Authors: Ortiz‐Ortiz Karen J. , Torres‐Cintrón Carlos R. , Suárez Ramos Tonatiuh , Castañeda‐Avila Maira A. , Cotto Santana Luis A. , Tortolero‐Luna Guillermo 
Published: November 2022

AbstractBackgroundThe use of markers has stimulated the development of more appropriate targeted therapies for chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). We assessed the use and prevalence of biological and genetic markers of CLL and AML in the homogeneous Hispanic population of Puerto Rico.MethodsWe used the Puerto Rico CLL/AML Population‐Based Registry, which combines information from linked databases. Logistic regression models were used to examine factors associated with biological and genetic testing.ResultsA total of 926 patients 18 years or older diagnosed with CLL (n = 518) and AML (n = 408) during 2011–2015 were included in this analysis. Cytogenetic testing (FISH) was reported for 441 (85.1%) of the CLL patients; of those, 24.0% had the presence of trisomy 12, 9.5% carried deletion 11q, 50.3% carried deletion 13q, and 6.3% carried deletion 17p. Regarding AML, patients with cytogenetics and molecular tests were considered to determine the risk category (254 patients), of which 39.8% showed poor or adverse risk. Older age and having more comorbidities among patients with CLL were associated with a lower likelihood of receiving a FISH test.ConclusionsAlthough prognostic genetic testing is required for treatment decisions, the amount of testing in this Hispanic cohort is far from ideal. Furthermore, some tests were not homogeneously distributed in the population, which requires further exploration and monitoring. This study contributes to the field by informing the medical community about the use and prevalence of biological and genetic markers of CLL and AML. Similarly, it has the potential to improve the management of CLL and AML through benchmarking.
Examining a community intervention to help White people understand race and racism and engage in anti‐racist behaviours
Authors: Banks Kira Hudson , Desdune Jasmine , Johnson Tanesha R. , Green Kyara 
Published: November 2022

AbstractUprisings over the past decade have accelerated the search for interventions to support White people in increasing their capacity to understand historical and present‐day racial dynamics. This study investigates the impacts and effectiveness of a community‐led intervention developed to prime White individuals to challenge injustice through increasing knowledge, confidence, and competence related to race, racism, intragroup dialogue, and colour‐blind racial attitudes. Five hundred and thirty seven participants were recruited from four cohorts of community‐led groups, which read, reflected, journaled, and completed activities related to race and racism for a total of 40 hr over 10 sessions. Participants were given pre‐ and post‐measures to assess their White racial capacity, and colour‐blind racial attitudes. Participants also completed a follow‐up assessment on anti‐racist behaviours. The results indicated that participants were able to increase their racial capacity in terms of their understanding and knowledge of race and racism. They also indicated that they felt more confident and competent to have racial discussions in an intergroup context. The possibilities and limitations of interventions to shift attitudes and behaviours are discussed.
Death by 1000 ‘true fans’: Do marketing laws apply to music listening?
Authors: Anesbury Zachary William , Davies Callum , Driesener Carl , Page Bill , Greenacre Luke , Yang Song , Bruwer Johan 
Published: November 2022

AbstractThe advice to musicians and marketers is to focus on what they love: a truism for practitioners is to find 1000 ‘true fans’ and make $100 from each of them (Kelly, 2008.1000 True fans. The Technium). If this advice is correct, we should see musicians with loyal user bases engaging more with their favourite artists and less with other music, suggesting a narrow targeting strategy would suffice. On the other hand, the established marketing laws indicate that the listeners of very different genres should overlap more than conventional wisdom would suggest, supporting the need for a much broader approach to targeting potential audiences. Given these conflicting views, musicians need to know if they should market to their existing listeners, the listeners of music similar to theirs (i.e., the same genre), or if they should try to reach a much wider audience. We turn to established choice patterns from the marketing literature to address these questions in the music context. This study examines 84,000,000 observations of music listening from 27,000 unique global users between 2013 and 2014 and survey data from 2019 containing music listening from over 1000 representative respondents in the United States. The results show that listening follows the Duplication of Purchase law for genres, artists, albums, and songs, at an annual, 6‐months, 3‐months, 1‐month, and 1‐week period, with no indication of partitioned music listening. The implication is that musicians should try to reachallpotential listeners, regardless of what they already listen to. These findings contribute to the theoretical knowledge about duplication analyses of various durations, extend the contexts of choice behaviour that exhibit this pattern, and managerially, to knowledge about the extent of potential audiences and ‘share of ear’ competition.
Hybrid approach for harmony transcatheter pulmonary valve replacement
Authors: Shibbani Kamel , Aboulhosn Jamil , Levi Daniel , Mohammad Nijres Bassel , Blais Benjamin , Karimi Mohsen , Van Arsdell Glen , Aldoss Osamah 
Published: November 2022

AbstractThe Harmony™ Transcatheter Pulmonary Valve (Medtronic) was recently approved by the Food and Drug Administration for transcatheter pulmonary valve replacement in native right ventricular outflow tracts. Despite this milestone, some patients have main pulmonary arteries that are severely dilated and continue to require surgical pulmonary valve replacement. The hybrid approach combines surgical creation of a landing zone, transcatheter valve deployment, and suture stabilization of the implanted valve. In this case series, we report the first use of a hybrid approach for Harmony™ transcatheter pulmonary valve replacement. Two cases are reported with varying approaches for surgical creation of a landing zone followed by successful placement of a Harmony™ valve.
Clinicopathological characteristics, treatments, and prognosis of breast ductal carcinoma in situ with microinvasion: A narrative review
Authors: Song Ge , Zhang Yongqiang 
Published: November 2022

AbstractBackgroundDuctal carcinoma in situ with microinvasion (DCIS‐MI) is defined as ductal carcinoma in situ (DCIS) with a microscopic invasive focus ≤1 mm in the longest diameter. The current literature is controversial concerning the clinical prognostic features and management of DCIS‐MI. This narrative review described recently reported literature regarding the characteristics, treatment, and prognosis of it.MethodsSearching PubMed for relevant articles covering the period of 1982 to 2021 using the following terms by MeSH and free‐word: breast cancer, microinvasion, DCIS, DCIS‐MI, and invasive ductal carcinoma (IDC).ResultsDCIS‐MI tends to express more aggressive pathological features such as necrosis, HER2+, ER‐ or PR‐, and high nuclear grade. The overall prognosis of DCIS‐MI is typically good, however, some indicators such as young age, HR‐, HER2+ and multimicroinvasive lesions, were associated with worse prognoses. And there are also conflicting results on the differences between the prognoses of DCIS‐MI and DCIS or T1a‐IDC. Postoperative chemotherapy and anti‐HER2 therapy still have uncertain benefits and are more likely to be used to treat high‐risk patients who are HR‐ orHER2+ to improve the prognosis.ConclusionDCIS‐MI has more aggressive pathological features, which may suggest its biological behavior is worse than that of DCIS and similar to early IDC. Although the overall prognosis of DCIS‐MI is good, when making decisions about adjuvant therapy clinicians need to give priority to the hormone receptor status, HER2 expression and axillary lymph node status of patients, because these may affect the prognosis and treatment response.
The effects of grazing cover crops on animal performance and soybean production
Authors: Rushing J. Brett , Bass Bronson S. , Lemus Rocky W. , Maples Joshua G. , Lyles Johnson C. 
Published: November 2022

AbstractGrazing cover crops has the potential to offset costs incurred with cover crop establishment, thus incentivizing management adoption. Information regarding cover crop species in combination with grazing and their subsequent effects on soybean production is limited. A field trial was conducted in Newton, MS from 2019 to 2021 to assess these effects. Cover crop treatments included oats (Avena sativa L.; O), O + crimson clover (Trifolium incarnatum L.; OC), and OC + radish (Raphanus sativus L.; OCR) and were applied in a randomized complete block design with three replications. Cover crops differed in nutritive analysis; O had significantly lower mean crude protein (CP), but greater total digestible nutrients (TDN). Weaned beef steers (Bos spp.) grazing cover crops had lower average daily gain (ADG) on the OCR treatment (3.03 lb hd−1 d−1), compared to O (3.52 lb hd−1 d−1) and OC (3.55 lb hd−1 d−1). No significant difference was observed in soybean (Glycine max L.) grain yield between cover crop treatments. Mean yields were 51.1, 46.1, and 38.7 bu ac−1 for the O, OC, and OCR treatments, respectively. Total net returns above crop production costs were significantly lower in the OCR ($475.98 ac−1), compared to the O ($706.29 ac−1) and OC ($651.83 ac−1) treatments. Findings suggest grazing oats or a combination of oats and crimson clover as a cover crop with subsequent soybean production has the potential to increase net returns for livestock–row crop producers though other costs associated with grazing will still need to be considered.
Modelling of catalytic reactors containing core–shell pellets with various morphologies for series reactions
Authors: Cho Young‐Sang 
Published: November 2022

AbstractModelling of series reactions was performed for core–shell catalysts. Mathematical solutions of concentrations inside the pellets were derived from reaction–diffusion equations considering inert‐core thickness (ξc) for first‐order kinetics. Transient behaviours of catalytic reactors containing core–shell pellets were predicted, assuming pseudo‐steady state approximation. In a batch reactor, the removal rate of reactants increased with increasing Thiele modulus and decreasing ξc in the order of sphere > cylinder > slab. The transient concentration of the intermediate product was maximum and affected by the distribution coefficient, diffusivity ratio, particle shape, and ξc. In a continuously stirred tank reactor, the concentration was affected by feed rate and catalyst loading, and conversion could be enhanced by a cascade connection. In a fixed‐bed reactor, the concentration increased with increasing ξc due to an insufficient catalyst volume. Péclet number and particle shape also affected the concentration, implying that axial dispersion and interfacial area are important design parameters.
Risk of subsequent primary lymphoma in a cohort of 69,460 five‐year survivors of childhood and adolescent cancer in Europe: The PanCareSurFup study
Authors: Dudley Isabelle M. , Sunguc Ceren , Heymer Emma J. , Winter David L. , Teepen Jop C. , Belle Fabiën N. , Bárdi Edit , Bagnasco Francesca , Gudmundsdottir Thorgerdur , Skinner Roderick , Michel Gisela , Byrne Julianne , Øfstaas Hilde , Jankovic Momcilo , Mazić Maja Česen , Mader Luzius , Loonen Jaqueline , Garwicz Stanislaw , Wiebe Thomas , Alessi Daniela , Allodji Rodrigue S. , Haddy Nadia , Grabow Desiree , Kaatsch Peter , Kaiser Melanie , Maule Milena M. , Jakab Zsuzsanna , Gunnes Maria Winther , Terenziani Monica , Zaletel Lorna Zadravec , Kuehni Claudia E. , Haupt Riccardo , de Vathaire Florent , Kremer Leontien C. , Lähteenmäki Päivi M. , Winther Jeanette F. , Hjorth Lars , Hawkins Michael M. , Reulen Raoul C. 
Published: November 2022

AbstractBackgroundSurvivors of Hodgkin lymphoma (HL) are at risk of developing non‐Hodgkin lymphoma (NHL) after treatment; however, the risks of developing subsequent primary lymphomas (SPLs), including HL and NHL, after different types of childhood cancer are unknown. The authors quantified the risk of SPLs using the largest cohort of childhood cancer survivors worldwide.MethodsThe Pan‐European Network for Care of Survivors After Childhood and Adolescent Cancer (PanCare) Survivor Care and Follow‐Up Studies (PanCareSurFup) cohort includes 69,460 five‐year survivors of childhood cancer, diagnosed during 1940 through 2008, from 12 European countries. Risks of SPLs were quantified by standardized incidence ratios (SIRs) and relative risks (RRs) using multivariable Poisson regression.ResultsOverall, 140 SPLs, including 104 NHLs and 36 HLs, were identified. Survivors were at 60% increased risk of an SPL compared with the general population (SIR, 1.6; 95% confidence interval [CI], 1.4–1.9). Survivors were twice as likely to develop NHL (SIR, 2.3; 95% CI, 1.9–2.8), with the greatest risks among survivors of HL (SIR, 7.1; 95% CI, 5.1–10.0), Wilms tumor (SIR, 3.1; 95% CI, 1.7–5.7), leukemia (SIR, 2.8; 95% CI, 1.8–4.4), and bone sarcoma (SIR, 2.7; 95% CI, 1.4–5.4). Treatment with chemotherapy for any cancer doubled the RR of NHL (RR, 2.1; 95% CI, 1.2–3.9), but treatment with radiotherapy did not (RR, 1.2; 95% CI, 0.7–2.0). Survivors were at similar risk of developing a subsequent HL as the general population (SIR, 1.1; 95% CI, 0.8–1.5).ConclusionsIn addition to HL, the authors show here for the first time that survivors of Wilms tumor, leukemia, and bone sarcoma are at risk of NHL. Survivors and health care professionals should be aware of the risk of NHL in these survivors and in any survivors treated with chemotherapy.
An efficient underground water prediction using optimal deep neural network
Authors: Sureshkumar V. , Rajasomashekar S. , Sarala B. 
Published: November 2022

SummaryFor the humanity to the whole and all the creatures of this world, the underground water is the greatest resource to rely upon that highly forms an indispensable factor toward augmented livelihood. In spite of the lack of detailed knowledge, global warming is found to profoundly influence underground water resources through changes in underground water recharge. Prediction of the underground water under a changing climate is essential to living beings. In this article, underground water prediction using optimal deep neural networks (optimal DNN) has been attempted. Initially, the features of temperature and rainfall among the input data have been selected and after which, the chosen data have been fed to the DNN to predict the underground water. In DNN, weight parameters are optimally selected with the help of fish swarm optimization (FSO). The implementation has been done on MATLAB. The simulation results found that the proposed FSO‐DNN prediction approach outperforms the existing prediction approaches by 78.9% accuracy, 83% sensitivity, 88% specificity, 95.8% positive predictive values, 52.3% negative predictive values, and 95.8% F‐measure.
A multikey fully homomorphic encryption privacy protection protocol based on blockchain for edge computing system
Authors: Liao Junguo , Wang Haifeng , Wu June 
Published: November 2022

SummaryIn order to protect private data in edge computing system and ensure that ciphertexts encrypted under different keys can be processed in the cloud, we propose a privacy protection protocol for edge computing, which is based on blockchain technology and multikey fully homomorphic encryption (MFHE). By constructing a Merkle hash tree and saving the Merkle root node to the blockchain, the integrity of the data in edge nodes is protected. For the data with high computational complexity in edge nodes, the GSW fully homomorphic encryption scheme is employed to process the encrypted private data of a single edge node by the CMS. The LinkAlgo algorithm is applied to link different keys by the relation between them, which enables the CMS to process the encrypted private data of multiple edge nodes. The security analysis and performance evaluation of the proposed privacy protection protocol show that our protocol has high security and good efficiency.
Secondary caries in fixed dental prostheses: Long‐term clinical evaluation
Authors: Alenezi Ali , Alkhudhayri Omar , Altowaijri Fahad , Aloufi Lina , Alharbi Fatimah , Alrasheed Maha , Almutairi Hind , Alanazi Abdulltif , Yehya Mohammed , Al Asmari Dhafer 
Published: November 2022

AbstractObjectivesEven with excellent fixed dental prostheses (FDPs), there will be a substantial risk of biological complications, such as caries, if proper oral hygiene is not maintained. This study aimed to evaluate the risks of developing secondary caries with FDPs in relation to the patient oral hygiene status.Material and MethodsClinical and radiographic examinations were performed for patients to collect data related to their FDP complications and oral hygiene status. The main clinical parameter analyzed was secondary caries. Complications such as a fracture, debonding, or the need for endodontic therapy were also analyzed. The interval survival rate and the cumulative survival rate of FDPs from the time of treatment to the time of follow‐up were analyzed.ResultsA total of 423 patients (with a total of 1116 FDPs) were examined in this study, with a mean age of 43.7 years and a mean follow‐up time of 7 years. Regarding complications, secondary caries was detected in 94 FDPs (8.4%), fracture (or chipping) in 85 (7.6%) cases, need for endodontic treatment in 42 cases (3.7%), and debonding in four (0.3%) cases. Secondary caries was found in nine out of 219 FDPs (4%) in patients with good oral hygiene, 35 out of 634 FDPs (5.5%) in patients with fair oral hygiene, and 50 out of 272 FDPs (18.4%) in patients with poor oral hygiene (p ≤ .001).ConclusionsGood oral hygiene has a great influence on reducing the risk of secondary caries in patients with FDPs. The occurrence of secondary caries is a common complication in patients with poor oral hygiene.