bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of COVID-19 Pandemic on Physical Activity, Pain, Mood, and Sleep in Adults With Knee Osteoarthritis
Authors: Rose Michael J. , LaValley Michael P. , Jafarzadeh S. Reza , Costello Kerry E. , Shah Nirali , Lee Soyoung , Borrelli Belinda , Messier Stephen P. , Neogi Tuhina , Kumar Deepak 
Published: September 2022

Objective: To examine changes in physical activity, sleep, pain, and mood in people with knee osteoarthritis during the ongoing COVID-19 pandemic by leveraging an ongoing randomized clinical trial. Methods: Participants enrolled in a 12-month parallel two-arm randomized clinical trial (NCT03064139) interrupted by the COVID-19 pandemic wore an activity monitor (Fitbit Charge 3) and filled out custom weekly surveys rating knee pain, mood, and sleep as part of the study. Data from 30 weeks of the parent study were used for this analysis. Daily step count and sleep duration were extracted from activity monitor data, and participants self-reported knee pain, positive mood, and negative mood via surveys. Metrics were averaged within each participant and then across all participants for prepandemic, stay-at-home, and reopening periods, reflecting the phased reopening in the state of Massachusetts. Results: Data from 28 participants showed small changes with inconclusive clinical significance during the stay-at-home and reopening periods compared with prepandemic for all outcomes. Summary statistics suggested substantial variability across participants with some participants showing persistent declines in physical activity during the observation period. Conclusion: Effects of the COVID-19 pandemic on physical activity, sleep, pain, and mood were variable across individuals with osteoarthritis. Specific reasons for this variability could not be determined. Identifying factors that could affect individuals with knee osteoarthritis who may exhibit reduced physical activity and/or worse symptoms during major lifestyle changes (such as the ongoing pandemic) is important for providing targeted health-care services and management advice toward those that could benefit from it the most.
Self-compassion, sleep quality and psychological well-being in type 2 diabetes: a cross-sectional study
Authors: Gunn Sarah , Henson Joseph , Robertson Noelle , Maltby John , Brady Emer M , Henderson Sarah , Hadjiconstantinou Michelle , Hall Andrew P , Rowlands Alex V , Yates Thomas , Davies Melanie J 
Published: September 2022

IntroductionLow self-compassion and poor sleep quality have been identified as potential key predictors of distress in type 2 diabetes (T2D). This study investigated relationships between sleep behaviors (sleep duration, social jetlag and daytime sleepiness), diabetes-related distress (DRD) and self-compassion in people with T2D.Research design and methodsThis cross-sectional study used data from 467 people with T2D derived from self-report questionnaires, accelerometer-assessed sleep measures and demographic information (clinicaltrials.gov registration:NCT02973412). All participants had a diagnosis of T2D and no comorbid sleep disorder (excluding obstructive sleep apnea). Hierarchical multiple regression and mediation analysis were used to quantify relationships between self-compassion, sleep variables and DRD.ResultsSignificant predictors of DRD included two negative subscales of the Self-Compassion Scale (SCS), and daytime sleepiness. The ‘overidentified’ and ‘isolation’ SCS subscales were particularly important in predicting distress. Daytime sleepiness also partially mediated the influence of self-compassion on DRD, potentially through self-care around sleep.ConclusionsDaytime sleepiness and negative self-compassion have clear associations with DRD for people with T2D. The specific negative subscale outcomes suggest that strengthening individuals’ ability to mindfully notice thoughts and experiences without becoming enmeshed in them, and reducing a sense of separateness and difference, might be key therapeutic targets for improving well-being in T2D. Psychological interventions should include approaches focused on reducing negative self-compassion and improving sleep behavior. Equally, reducing DRD may carry beneficial outcomes for sleep and self-compassion. Further work is however crucial to establish causation and long-term impact, and for development of relevant clinical resources.
‘Every patient, every day’: a daily ward round tool to improve patient safety and experience
Authors: Johnston Judith , Stephenson John , Rajgopal Anu , Bhasin Neeraj 
Published: September 2022

IntroductionMany essential interventions are required to ensure in-patients receive safe and effective care with a good experience. In addition, healthcare organisations are assessed on numerous performance indicators, including the aforementioned interventions, where underperformance can lead to lower publicly reported ratings, loss of income and reputational damage. Most importantly, underperformance can lead to compromised patient experience and outcomes. We created a prompt card as a service improvement tool to be used on the daily ward rounds at the bedside of every patient, entitled ‘every patient, every day’ to improve documentation, antibiotic prescribing, venous thromboembolism (VTE) prophylaxis, coding and patient communication.MethodPreimplementation data around these interventions and patient experience factors were collected by shadowing ward rounds. The ‘every patient, every day’ tool was then implemented. The ward rounds were shadowed by the same individual to collect post-implementation data. Effect of implementation was assessed via Poisson regression models conducted on the documentation, antibiotics and VTE measures, and logistic regression models conducted on the communication and coding measures.ResultsThe corresponding rate ratios for the effect of the implementation of the service improvement tool were found to be 1.53 (95% CI 1.38 to 1.69) for improved documentation. Antibiotics prescribing improved by 1.44 (95% CI 1.06 to 1.94). VTE prescribing and documentation improved by a rate ratio 1.25 (95% 1.04 to 1.50). For communication, the effect of the implementation was significant at the 5% significance level (p<0.001), with an OR of 18.6 (95% CI 8.41 to 41.09). Coding effect was non-significant at the 5% significance level (p=0.113) but was substantive. Implementation of the tool resulted in substantive improvements in all outcomes and shows corrected significance with the documentation and communication outcomes.ConclusionThe ‘every patient, every day’ ward round prompt card is an extraordinarily simple tool shown to increase compliance with a number of safety and quality indicators to improve an organisation’s performance, and hopefully be a facet contributing to enhanced patient experience and outcomes.
Compliance to donning and doffing of personal protective equipment among dental healthcare practitioners during the coronavirus pandemic: a quality improvement plan, do, study and act (PDSA) Initiative
Authors: Qabool Hafsa , Ali Faiza , Sukhia Rashna Hoshang , Badruddin Naila 
Published: September 2022

IntroductionWith the emergence of SARS-Cov-2, the Centers for Disease Control and Prevention (CDC) defined mandatory guidelines for donning and doffing personal protective equipment (PPE) among dental healthcare professionals. The study’s objective was to improve the compliance of the donning and doffing protocols for PPE among dental practitioners by the Plan, Do, Study, and Act (PDSA) cycle.Materials and methodsA quasi-experimental study was conducted on a sample of dental healthcare professionals using the non-probability purposive technique. In the first planning stage, compliance with CDC-approved donning and doffing was assessed on the clinical premises. In the second stage, an educational session was arranged with all the healthcare professionals to explain stepwise guidelines of donning and doffing to improve the quality of donning and doffing compliance. In the third stage, improvement in the quality outcome was then assessed after the session. Data were normally distributed. Qualitative variables for all the steps of donning and doffing are reported as frequency and percentages. Pareto charts were made to assess the non-compliance rate for donning and doffing protocols among dental healthcare professionals.ResultsThere was an improvement of 44.55% in the hand hygiene practices before wearing the PPE after the second step of the PDSA cycle. A percentage improvement of 7.4% was recorded for removing jewellery, wearing the gown and wearing a surgical cap. No improvement was seen in securing the mask/ respirator ties, washing hands after wearing the respirator, placing the goggles or face shield practices.ConclusionsPDSA cycle improved the overall compliance to PPE donning and doffing practices. Most of the protocols were followed by the dental healthcare professionals; however, some of them remained the same or worsened due to ease in SARS-CoV 2 restrictions.
Safety and efficacy of drug coated balloon angioplasty for intracranial atherosclerotic disease
Authors: Qiao Hanzi , Chang Chien-Hung , Wang Alvin Yi-Chou , Li Shaoxue , Yang Weilin , Li Guoming , Cen Xuecheng , Wang Rongfei , Lin Hao 
Published: September 2022

BackgroundDrug coated balloon (DCB) angioplasty can provide sustained anti-restenotic efficacy without the limitations of permanent vascular implantation and is presumably ideal for treating intracranial atherosclerotic disease. However, the safety of paclitaxel in the neurovasculature remains a concern.Methods242 patients with angiographically verified symptomatic stenosis >70% in intracranial arteries treated with DCB angioplasty were reviewed divided into two groups: group A, patients with stenotic intracranial arteries; and group B, patients with acute, subacute, or chronic occluded intracranial arteries. The primary endpoint was any stroke or death within 30 days. The secondary endpoint was arterial restenosis of >50% during follow-up.Results16 major and 12 minor complications occurred among 245 procedures (6.5% and 4.9%, respectively). Five patients died within 30 days after the procedure (2.1%, 5/242). 12 major and 12 minor complications occurred among 211 procedures in group A (5.7% and 5.7%). In group B, four major complications occurred among 34 procedures (11.8%). Hyperperfusion and perforator stroke accounted for half of all complications (53.6%, 15/28). Restenosis >50% was present in eight lesions during the follow-up period (4.8%, 8/167).ConclusionsAfter treatment with DCB angioplasty, complications were no different from those after standard balloon angioplasty or stenting. This study suggests that DCB angioplasty may be a safe and effective procedure for intracranial arterial stenosis.
Effect of bleeding risk prediction on decision making of intravenous thrombolysis before thrombectomy: a subgroup analysis of DIRECT-MT
Authors: Yan Shenqiang , Zhang Minmin , Zhou Huan , Zhou Ying , Chen Yi , Zhang Xuting , Chen Zhicai , Yang Pengfei , Zhang Yongwei , Zhang Lei , Li Zifu , Xing Pengfei , Sun Jun , Lou Min , Liu Jianmin 
Published: September 2022

BackgroundThe major concern for bridging intravenous thrombolysis (IVT) before endovascular thrombectomy (EVT) is the potentially increased risk of symptomatic intracerebral hemorrhage (sICH). Thus we conducted this study to clarify whether evaluation of individual bleeding risk could assist in the decision to perform IVT before EVT.MethodsThe study was a subgroup analysis of a randomized trial evaluating the safety and efficacy of IVT before EVT. The SEDAN (blood Sugar, Early infarct signs and (hyper) Dense cerebral artery sign, Age, and National Institutes of Health Stroke Score) score, GRASPS (Glucose, Race, Age, Sex, systolic blood Pressure, and Severity of stroke) score, and SITS-SICH (Safe Implementation of Thrombolysis in Stroke-Symptomatic Intracerebral Hemorrhage) score were used to evaluate individual bleeding risk. The primary outcome was functional independence, defined as a modified Rankin Scale (mRS) score of 0–2 at 90 days. Binary logistic regression with an interaction term was used to estimate treatment effect modification to clarify whether direct EVT was more beneficial in patients with a higher sICH risk, while adjunctive IVT before EVT was more beneficial in patients with a lower sICH risk.ResultsAmong 658 randomized patients, 639 (361 men, 56.5%; median age 69 (IQR 61–76) years) were included in the study. With the SITS-SICH score as an example, adjusted OR for functional independence with EVT alone was 1.12 (95% CI 0.68 to 1.82) in patients with a lower sICH risk (SITS-SICH score 0–4) and 0.92 (0.53 to 1.60) in those with a higher sICH risk (SITS-SICH score 5–15). There were no treatment-by-bleeding-risk interactions for all dichotomized mRS outcomes based on the three scores (all p>0.05).ConclusionsWe found no evidence that clinicians can decide whether to omit IVT before EVT based on an individualized assessment of bleeding risk.
Prevalence and clinical significance of arrhythmias during labour in women with structurally normal hearts
Authors: Sharma Nikhil , Coleman Kristie , Ma Rosaline , Gurciullo Dillon , Bimal Tia , Ansari Umair , Wolf Elliot , Liu Yan , Hentz Roland , Mountantonakis Stavros E 
Published: September 2022

ObjectivesExamine the association between arrhythmias and adverse maternal outcomes in women with structurally normal hearts.MethodsThis was a case–control study of women admitted in labour to one of eight hospitals of Northwell Health from January 2015 to June 2021. After excluding women with structurally abnormal hearts, we identified women with an arrhythmic event and randomly subsampled the rest of the cohort to create a control group of 1025 patients. Multivariate analysis was performed to examine the association between arrhythmias and the incidence of caesarean section (CS), preterm labour (PTL), admission to the neonatal intensive care unit and longer length of stay (LOS).ResultsOf 1 41 769 women admitted in labour with a structurally normal heart, 137 had at least one arrhythmic event (0.097%). Supraventricular tachycardia (SVT), atrial fibrillation/flutter (AF) and frequent premature ventricular complexes or non-sustained ventricular tachycardia (VA) were present in 65 (0.046%), 22 (0.016%) and 46 (0.032%) women, respectively. Arrhythmia was previously diagnosed in 58.0% SVT cases but only in 9.7% AF and 8.1% VA cases. After adjusting for age, parity and comorbidities, the presence of any arrhythmia was an independent predictor of CS (OR 1.7 95% CI 1.2 to 2.5), PTL (OR 1.8, CI 1.1 to 3.0) and LOS (mean ratio 1.6, CI 1.4 to 1.8). This association was driven by presence of SVT and AF, whereas VAs were not associated with adverse outcomes.ConclusionsArrhythmias, specifically SVT and AF, during labour in women with structurally normal heart are independently associated with adverse obstetrical outcomes.
A Methylation Diagnostic Model Based on Random Forests and Neural Networks for Asthma Identification
Authors: Li Dong-Dong , Chen Ting , Ling You-Liang , Jiang YongAn , Li Qiu-Gen 
Published: September 2022

Background. Asthma significantly impacts human life and health as a chronic disease. Traditional treatments for asthma have several limitations. Artificial intelligence aids in cancer treatment and may also accelerate our understanding of asthma mechanisms. We aimed to develop a new clinical diagnosis model for asthma using artificial neural networks (ANN). Methods. Datasets (GSE85566, GSE40576, and GSE13716) were downloaded from Gene Expression Omnibus (GEO) and identified differentially expressed CpGs (DECs) enriched by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Random forest (RF) and ANN algorithms further identified gene characteristics and built clinical models. In addition, two external validation datasets (GSE40576 and GSE137716) were used to validate the diagnostic ability of the model. Results. The methylation analysis tool (ChAMP) considered DECs that were up-regulated (

n

=121) and down-regulated (

n

=20). GO results showed enrichment of actin cytoskeleton organization and cell-substrate adhesion, shigellosis, and serotonergic synapses. RF (random forest) analysis identified 10 crucial DECs (cg05075579, cg20434422, cg03907390, cg00712106, cg05696969, cg22862094, cg11733958, cg00328720, and cg13570822). ANN constructed the clinical model according to 10 DECs. In two external validation datasets (GSE40576 and GSE137716), the Area Under Curve (AUC) for GSE137716 was 1.000, and AUC for GSE40576 was 0.950, confirming the reliability of the model. Conclusion. Our findings provide new methylation markers and clinical diagnostic models for asthma diagnosis and treatment.
Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets
Authors: Shah Urvi A. , Maclachlan Kylee H. , Derkach Andriy , Salcedo Meghan , Barnett Kelly , Caple Julia , Blaslov Jenna , Tran Linh , Ciardiello Amanda , Burge Miranda , Shekarkhand Tala , Adintori Peter , Cross Justin , Pianko Matthew J. , Hosszu Kinga , McAvoy Devin , Mailankody Sham , Korde Neha , Hultcrantz Malin , Hassoun Hani , Tan Carlyn R. , Lu Sydney X. , Patel Dhwani , Diamond Benjamin , Shah Gunjan , Scordo Michael , Lahoud Oscar , Chung David J. , Landau Heather , Usmani Saad Z. , Giralt Sergio , Taur Ying , Landgren C. Ola , Block Gladys , Block Torin , Peled Jonathan U. , van den Brink Marcel R.M. , Lesokhin Alexander M. 
Published: September 2022

Abstract

Purpose:
Sustained minimal residual disease (MRD) negativity is associated with long-term survival in multiple myeloma. The gut microbiome is affected by diet, and in turn can modulate host immunity, for example through production of short-chain fatty acids including butyrate. We hypothesized that dietary factors affect the microbiome (abundance of butyrate-producing bacteria or stool butyrate concentration) and may be associated with multiple myeloma outcomes.

Experimental Design:
We examined the relationship of dietary factors (via a food frequency questionnaire), stool metabolites (via gas chromatography–mass spectrometry), and the stool microbiome (via 16S sequencing - ±-diversity and relative abundance of butyrate-producing bacteria) with sustained MRD negativity (via flow cytometry at two timepoints 1 year apart) in myeloma patients on lenalidomide maintenance. The Healthy Eating Index 2015 score and flavonoid nutrient values were calculated from the food frequency questionnaire. The Wilcoxon rank sum test was used to evaluate associations with two-sided P &lt; 0.05 considered significant.

Results:
At 3 months, higher stool butyrate concentration (P = 0.037), butyrate producers (P = 0.025), and ±-diversity (P = 0.0035) were associated with sustained MRD negativity. Healthier dietary proteins, (from seafood and plants), correlated with butyrate at 3 months (P = 0.009) and sustained MRD negativity (P = 0.05). Consumption of dietary flavonoids, plant nutrients with antioxidant effects, correlated with stool butyrate concentration (anthocyanidins P = 0.01, flavones P = 0.01, and flavanols P = 0.02).

Conclusions:
This is the first study to demonstrate an association between a plant-based dietary pattern, stool butyrate production, and sustained MRD negativity in multiple myeloma, providing rationale to evaluate a prospective dietary intervention.
Watch the interview with Urvi A. Shah, MD, recipient of the inaugural Clinical Cancer Research Early Career Award: https://vimeo.com/992991936
The Origin of the Phenomenology of Attention
Authors: Byrne Thomas 
Published: September 2022

Abstract
This paper accomplishes two tasks. First, I unpack Husserl’s analysis of interest from his 1893 manuscript, “Notes Towards a Theory of Attention and Interest” to demonstrate that it comprises his first rigorous genetic analysis of attention. Specifically, I explore Husserl’s observations about how attentive interest is passively guided by affections, moods, habits, and cognitive tensions. In doing so, I reveal that the early Husserl described attention as always pulled forward to new discoveries via the rhythmic recurrence of tension and pleasure. Second, I demonstrate that “Notes” is the germ of Husserl’s mature genetic phenomenology of attention. The 1893 analysis provides Husserl with all of the philosophical reasons and tools for the construction of his genetic account of attention in his late works. I then discuss how the disclosure of this novel subterranean link can prompt a rethinking of the development of phenomenology.
Advancing Interdisciplinary and Convergent Science for Communities: Lessons Learned through the NCAR Early-Career Faculty Innovator Program
Authors: Bukvic Anamaria , Mandli Kyle , Finn Donovan , Mayo Talea , Wong-Parodi Gabrielle , Merdjanoff Alexis , Alland Joshua , Davis Christopher , Haacker Rebecca , Morss Rebecca , O’Lenick Cassandra , Wilhelmi Olga , Lombardozzi Danica 
Published: September 2022

Abstract
The authors introduce the National Center for Atmospheric Research’s Early-Career Faculty Innovator Program and present lessons learned about advancing interdisciplinary and convergent science with and for society. The Innovator Program brings together faculty and students from the social sciences with NCAR researchers to conduct interdisciplinary and convergent research on problems motivated by societal challenges in the face of climate change and environmental hazards. This article discusses aspects of program structure and the research being conducted. The article also emphasizes the challenges and successes of the research collaborations within the Innovator Program, along with lessons learned about engaging in highly interdisciplinary, potentially convergent work, particularly from the early-career perspective. Many projects involve faculty PIs from racially, ethnically, or otherwise minoritized groups, and minority serving institutions (MSIs), or those who engage with marginalized communities. Hence, the Innovator Program is contributing to the development of a growing research community pursuing science with and for society that also broadens participation in research related to the atmospheric sciences.
Incidence of Red Cell Antibody Formation Following Massive Transfusion Protocol: Experience of a Single Institution
Authors: Hairston Hayden C. , Ipe Tina S. , Burdine Lyle , Sexton Kevin , Reif Rebecca , Jensen Hanna , Kalkwarf Kyle J. 
Published: September 2022

Background Injured patients in hemorrhagic shock have a survival benefit with massive transfusion protocol (MTP). While there are many published studies on the transfusion management of massively bleeding patients, the risk of alloimmunization in patients that have received products during an MTP activation is relatively unknown. Therefore, we sought to determine the frequency of new antibody formation in MTP patients that received blood products from an uncrossmatched megapack. Materials and Methods We conducted a retrospective data review of patients who underwent an MTP activation for trauma resuscitation between May 2014 and July 2020. Data were collected from patients who met the following criteria: MTP was activated, the patients received at least one unit of packed red blood cells, one unit of fresh frozen plasma, one unit of platelets, and had a repeat type and screen within 6 weeks of transfusion. These inclusion criteria resulted in 28 patients over the 6-year timeframe. Results Overall, the risk of alloimmunization secondary to MTP is 3.6% in our trauma patient population. The newly developed antibodies post-MTP are considered clinically significant, meaning they can cause hemolysis if exposed to donor red blood cells containing those antigens. Discussion Blood products should be given preferentially over crystalloids to acutely bleeding patients to prevent ischemic injury during an MTP activation despite the risk of alloimmunization. In our single-institution study, the alloimmunization rate in massive transfusions where patients receive uncrossmatched red blood cells is similar to those receiving crossmatched red blood cells.