bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cortico-Striatal Control over Adaptive Goal-Directed Responding Elicited by Cues Signaling Sucrose Reward or Punishment
Authors: Hamel Laurie , Cavdaroglu Bilgehan , Yeates Dylan , Nguyen David , Riaz Sadia , Patterson Dylan , Khan Nisma , Kirolos Nardin , Roper Katherine , Ha Quynh An , Ito Rutsuko 
Published: March 2022

The medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) have been associated with the expression of adaptive and maladaptive behavior elicited by fear-related and drug-associated cues. However, reported effects of mPFC manipulations on cue-elicited natural reward-seeking and inhibition thereof have been varied, with few studies examining cortico-striatal contributions in tasks that require adaptive responding to cues signaling reward and punishment within the same session. The current study aimed to better elucidate the role of mPFC and NAc subdivisions, and their functional connectivity in cue-elicited adaptive responding using a novel discriminative cue responding task. Male Long–Evans rats learned to lever-press on a VR5 schedule for a discriminative cue signaling reward, and to avoid pressing the same lever in the presence of another cue signaling punishment. Postacquisition, prelimbic (PL) and infralimbic (IL) areas of the mPFC, NAc core, shell, PL-core, or IL-shell circuits were pharmacologically or chemogenetically inhibited while animals performed under (1) nonreinforced (extinction) conditions, where the appetitive and aversive cues were presented in alternating trials alone or as a compound stimulus; and (2) reinforced conditions, whereby cued responding was accompanied by associated outcomes. PL and IL inactivation attenuated nonreinforced and reinforced goal-directed cue responding, whereas NAc core and shell inactivation impaired nonreinforced responding for the appetitive, but not aversive cue. Furthermore, PL-core and IL-shell inhibition disinhibited nonreinforced but not reinforced cue responding. Our findings implicate the mPFC as a site of confluence of motivationally significant cues and outcomes, and in the regulation of nonreinforced cue responding via downstream NAc targets.SIGNIFICANCE STATEMENTThe ability to discriminate and respond appropriately to environmental cues that signal availability of reward or punishment is essential for survival. The medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) have been implicated in adaptive and maladaptive behavior elicited by fear-related and drug-associated cues. However, less is known about the role they play in orchestrating adaptive responses to natural reward and punishment cues within the same behavioral task. Here, using a novel discriminative cue responding task combined with pharmacological or chemogenetic inhibition of mPFC, NAc and mPFC-NAc circuits, we report that mPFC is critically involved in responding to changing cued response-outcomes, both when the responses are reinforced, and nonreinforced. Furthermore, the mPFC coordinates nonreinforced discriminative cue responding by suppressing inappropriate responding via downstream NAc targets.
El trabajo con textos publicitarios en las escuelas para promover el desarrollo de la lectura crítica
Authors: Fernández Martha Liliana 
Published: March 2022

El presente artículo de reflexión es producto de una investigación elaborada en el 2021 para la Facultad de Ciencias Sociales, Humanidades y Artes de la Universidad Autónoma de Bucaramanga, cuyo objetivo fue diseñar una propuesta pedagógica para promover el mejoramiento de los procesos de comprensión de lectura y de lectura crítica a través del análisis del discurso publicitario en los estudiantes de quinto de primaria del colegio San Luis del municipio de Aratoca. La propuesta partió de un diagnóstico sobre las problemáticas que limitan la comprensión de lectura, y de un proceso de revisión de literatura para orientar estrategias concretas de solución a la problemática.
En este artículo se plantea como objetivo esencial profundizar el conocimiento de las cualidades, usos y funciones de los textos publicitarios, como herramientas que pueden no solo ayudar a mejorar los procesos de comprensión de lectura, sino también a formar ciudadanos más críticos y reflexivos, que tengan la capacidad de diferenciar la realidad de las representaciones que se presentan en la publicidad.
Se parte de reconocer que, a nivel general, existe una marcada polarización entre la escuela y los medios de comunicación, pues obedecen a finalidades distintas: la primera dirigida a la formación de ciudadanos, y la segunda a la creación de hábitos de consumo. Sin embargo, es preciso superar dicha polarización a través de prácticas reflexivas que les permitan a los estudiantes entender mejor la intención de los textos publicitarios y potenciar además capacidades asociadas a la lectura y el pensamiento crítico.
Discurso de interacción social de Teun Van Dijk y desarrollo de competencia oral en estudiantes de bachillerato de la Escuela industrial 20 de julio, Puerto Wilches
Authors: Vargas Reyes Deysi Johanna 
Published: March 2022

En el presente artículo de reflexión se exponen aspectos importantes sobre la incidencia de la teoría del discurso de interacción social de Teun Van Dijk, en el desarrollo de la competencia oral de los estudiantes de noveno grado. El trabajo partió de la identificación del problema, el cual está centrado en fortalecer la oralidad de los estudiantes, además de optimizar la interacción social mediante el uso adecuado del discurso. Con base en ello, se procedió a una documentación amplia que fue plasmada en el marco teórico en el que se tuvieron en cuenta aspectos tales como: La teoría del discurso de interacción social, la competencia oral y la expresión oral que serán la base para el proceso metodológico, y que se ejecutará mediante un enfoque cualitativo, método Investigación – Acción, en el que participarán cinco docentes del área de lengua castellana que responderán preguntas planteadas de acuerdo a las categorías de análisis referente al discursos de interacción social, dimensiones del habla y discurso y sociedad. Asimismo, entrarán al escenario nueve estudiantes del grado noveno que desarrollarán una prueba diagnóstica en el que se tendrán en cuenta las categorías ya mencionadas. Es preciso señalar que la información recolectada será registrada en un diario de campo que permitirá un análisis minucioso de los fenómenos detectados. En cuanto a los resultados, se espera que la estrategia didáctica ayude al desarrollo de habilidades orales de los estudiantes y mejorando sus procesos comunicativos entre estudiante – estudiante y estudiante – docente.
Report of RILEM TC 267-TRM phase 2: optimization and testing of the robustness of the R3 reactivity tests for supplementary cementitious materials
Authors: Avet François , Li Xuerun , Ben Haha Mohsen , Bernal Susan A. , Bishnoi Shashank , Cizer Özlem , Cyr Martin , Dolenec Sabina , Durdzinski Pawel , Haufe Johannes , Hooton Doug , Juenger Maria C. G. , Kamali-Bernard Siham , Londono-Zuluaga Diana , Marsh Alastair T. M. , Marroccoli Milena , Mrak Marusa , Parashar Anuj , Patapy Cédric , Pedersen Malene , Provis John L. , Sabio Serge , Schulze Simone , Snellings Ruben , Telesca Antonio , Thomas Michael , Vargas Felipe , Vollpracht Anya , Walkley Brant , Winnefeld Frank , Ye Guang , Zhang Shizhe , Scrivener Karen 
Published: March 2022

AbstractThe results of phase 1 of an interlaboratory test, coordinated by the RILEM TC 267-TRM “Tests for Reactivity of Supplementary Cementitious Materials” showed that the R3 (rapid, relevant, reliable) test method, by measurement of heat release or bound water, provided the most reliable and relevant determination of the chemical reactivity of supplementary cementitious materials (SCMs), compared to other test methods. The phase 2 work, described in this paper aimed to improve the robustness of the test procedure and to develop precision statements for the consolidated test procedure. The effect of the pre-mixing and mixing conditions, and the impact of the mix design on the test method robustness were assessed and fixed for optimal conditions to carry out the R3 heat release test. The effect of the drying step was evaluated to define the R3 bound water test procedure in more detail. Finally, the robustness of the consolidated final test methods was determined by an interlaboratory study to define the precision statements.
The Structure of Space-time and the Emergence of Complex Life
Authors: Serpa Nilo 
Published: March 2022

<p><strong>Abstract</strong>. This article is a continuation of the work started in 2016 by Serpa and Steiner on the structure of space-time. The original theory proposes an alternative to the idea of direct quantization of gravity through a semi-classical evolutionary model, now associated with an entropic principle applied to the accelerated expansion of the universe. This principle relates the emergence of intelligent life to an expectation value of the expansion rate of space-time. The theory is consistent with general relativity and observational cosmology at its current stage of technological development, making a test program plausible in the relatively near future.</p><p><strong>Key words</strong>: space-time, gravity, entropy, general relativity.</p><p>=====================================================================</p><p><strong>Resumo</strong>. Este artigo é uma continuação do trabalho iniciado por Serpa e Steiner em 2016 sobre a estrutura do espaço-tempo. A teoria original propõe uma alternativa à ideia de quantização direta da gravidade por meio de um modelo evolutivo semiclássico, agora associado a um princípio entrópico aplicado à expansão acelerada do universo. Este princípio relaciona o surgimento de vida inteligente a um valor de espera da taxa de expansão do espaço-tempo. A teoria é consistente com a relatividade geral e com a cosmologia observacional em seu estágio atual de desenvolvimento tecnológico, tornando plausível um programa de teste em futuro relativamente próximo.</p><p><strong>Palavras-chave</strong>: espaço-tempo, gravidade, entropia, relatividade geral.</p>
A case of acquired thrombotic thrombocytopenic purpura (TTP) mimicking transient ischemic attack (TIA)
Authors: Bose Some Suvra , Sen Bonny , Roy Debapriya , Shaikh Alamgir 
Published: March 2022

TTP is a rare multisystem disease among children due to dysfunction of ADAMTS 13 enzyme in plasma causing defective vWF cleavage, thus giving rise to platelet aggregation, micro thrombi formation, platelet consumption, capillary blockage and finally organ dysfunction leading to a severe life-threatening condition with mortality around 90% if untreated. It can be congenital (5%) or acquired (95%) and Plasmapheresis works wonder for both the subtypes.: Here we have described a case of acquired TTP masquerading TIA in an 8-year-old girl child who had attacks of sudden onset aphasia and upper limb weakness lasting for few hours with spontaneous recovery. On detailed examination we found pallor and few petechial spots on face and upper limbs with a peripheral blood picture suggestive of thrombocytopenia with microangiopathic hemolytic anemia but a normal renal function. We sent blood for ADAMTS 13 activity which reported a critically low level of ADAMTS 13 enzymatic activity with presence of inhibitors and absent genetic mutation. Immediate Plasmapheresis was started along with oral prednisolone therapy for a span of one month which resulted both clinical and hematological recovery. Platelet count acted as a good indicator of clinical remission. A high degree of clinical suspicion is required to make a prompt diagnosis of this life threatening disease (TTP) since this carries a very high mortality rate and can mimic a more common disease HUS.
Evaluation of Self-Care and its Association with Quality of Life in Patients with Type 2 Diabetes
Authors: Gholizadeh Masoumeh , Heydari Somayeh , Mir Nazanin , Taghipour Havjin , Hatamzadeh Nasser , Jalilian Habib 
Published: March 2022

Background: Diabetes is a chronic illness which requires continuous self-care. Appropriate self-care can reduce the risks of developing complications and improve the Quality of Life (QoL). This study aimed to examine self-care and its association with quality of life in patients with type 2 diabetes (T2DM) in East Azerbaijan, Iran, in 2018.
Methods: This was a cross-sectional study. The statistical population included all patients with type 2 diabetes in East Azerbaijan, in 2018. 310 patients were included using consecutive sampling. The summary of Diabetes Self-Care Activities Questionnaire (SDSCA) and the 12-Item Short Form Health Survey questionnaire (SF-12) were used for data collection. Data were analyzed using SPSS22. Descriptive statistics such as mean, Standard Deviation (SD), frequency, and percentage were applied to describe the characteristics of the respondents. The Spearman correlation, Mann Whitney U and Kruskal–Wallis tests were applied for statistical analysis.
Results: The mean scores of self-care and QoL were estimated to be 42.14 ± 61.63 and 53.25 ± 51.73, respectively. The highest mean of self-care and QoL was related to medications and social functioning which were 96.03 and 68.34. There was no correlation between the total mean score of self-care and QoL (P-value = 0.65). Moreover, a significant correlation was found between medication (insulin), exercise, blood-glucose testing and the total score of QoL (P-value < 0 .05).
Conclusion: The results indicated that self-care in patients with diabetes is poor, and the patients’ QoL is moderate. Therefore, it is suggested that managers of health centres take appropriate measures such as educational programs and executive interventions to enhance self-care in patients with diabetes. Moreover, to increase QoL, more attention should be paid to promote exercise and diet behaviours.
Conocimientos, actitudes y prácticas basadas en evidencias de fisioterapeutas docentes en una universidad del Perú
Authors: Mayhua Ramírez Shelley Jiroshi , Ortiz Ruiz María Inés , Bahamonde Vílchez Elva , Rojas-Vilca José Luis 
Published: March 2022

Objetivo: Describir los conocimientos, actitudes y prácticas basadas en la evidencia de fisioterapeutas docentes de una universidad del Perú. Material y métodos: Estudio observacional, descriptivo y transversal. El instrumento utilizado fue el cuestionario diseñado por Jette et al., modificado y validado por Conislla et al. Resultados: Se invitó a 56 fisioterapeutas docentes, de los cuales 46 (82,1%) contestaron y retornaron la encuesta. La mayoría estaba familiarizada con los motores de búsqueda bibliográfica (82,7%). El 95,7% reportó interés en aprender o mejorar habilidades necesarias para incorporar una PBE en su labor diaria. En un mes habitual, el 69,5% leen de 5 o menos artículos y el 69,6% usa la literatura científica 2-10 veces por mes para la toma de decisiones. La barrera principal fue tiempo insuficiente (56,5%). Conclusiones: Los fisioterapeutas docentes reportaron conocer los fundamentos en PBE y sistemas de búsqueda. Además, interés hacia aprender o mejorar sus habilidades; sin embargo, reconocen la necesidad de aumentar el uso de la evidencia en su práctica habitual.
Diagnostic value of a new cryoprobe for peripheral pulmonary lesions: a prospective study
Authors: Tanaka Midori , Matsumoto Yuji , Imabayashi Tatsuya , Kawahara Takuya , Tsuchida Takaaki 
Published: March 2022

Abstract
Background: Cryobiopsy is an established technique that yields larger and higher-quality samples than does a forceps biopsy. However, it remains underutilised in the diagnosis of peripheral pulmonary lesions (PPLs), mainly because of difficulties in handling conventional cryoprobes. A recently introduced single-use cryoprobe with a smaller diameter and more flexibility than conventional ones may improve its diagnostic ability for PPLs. We conducted this prospective study to evaluate the feasibility of transbronchial cryobiopsy in the diagnoses of PPLs, using a new 1.7-mm cryoprobe. Methods: The study included patients with PPLs less than 30 mm in diameter scheduled to undergo bronchoscopy. All the procedures were performed using a combination of virtual bronchoscopic navigation, radial endobronchial ultrasound (R-EBUS) and X-ray fluoroscopy, and all the samples were collected using the cryoprobe alone. Thereafter, we assessed the diagnostic outcomes and safety profiles.Results: A total of 50 patients were enrolled and underwent cryobiopsy. The median lesion size was 20.8 mm (range, 8.2–29.6 mm), and the negative bronchus sign was seen in 34% of lesions. The diagnostic yield was 94% (95% confidence interval, 83.5–98.8%). A positive bronchus sign had a significantly higher diagnostic yield than did a negative bronchus sign (100% vs. 82.4%; P=0.035). The yield was achieved regardless of other variables, including lesion size, location, and R-EBUS findings. The major complications were mild and moderate bleeding in 28% and 62% of patients, respectively. Pneumothorax was identified in one patient.Conclusion: Transbronchial cryobiopsy using the new 1.7-mm cryoprobe is a feasible procedure that has the potential to increase the diagnostic accuracy for PPLs.Trial Registration: Japan Registry of Clinical Trials, jRCT1032200065. Registered July 8 2020, https://jrct.niph.go.jp/en-latest-detail/jRCT1032200065
The use of novel liquid mulching formulations (hydromulching) increases yield and quality of artichoke (Cynara cardunculus var. scolymus) by improving soil physicochemical and biological properties
Authors: Romero-Muñoz Miriam , Gálvez Amparo , Amor Francisco M. del , Albacete Alfonso , López-Marín Josefa 
Published: March 2022

Abstract
Purpose: We hypothesized that organic liquid mulching formulations called hydromulching can be used in sustainable agricultural production through its direct influence on soil physicochemical and biological properties to improve crop yield and quality. Methods: Artichoke plants were grown using three hydromulching treatments, rice hulls (RH), wheat straw (WS), and mushroom substrate (MS), and two control treatments, soil covered with polyethylene (PE) and bare soil (BS). Soil quality-related parameters and artichoke head physical and chemical properties were measured for each mulching treatment.Results: Soil organic matter and soil organic carbon increased in all hydromulching treatments, especially with the RH cover. Soil moisture and the contents of K+, P, Cu2+, Mn2+, and Zn2+ enhanced in hydromulched soils, particularly in MS-covered soil. The WS treatment produced the highest crop yield, while the lowest yield was obtained in bare soil. Importantly, plant water relationships were superior in all mulching treatments giving rise to the improvement of crop yield and the most important physical quality parameters in artichoke, namely color, firmness, and size. Furthermore, the content of some important nutrient elements in artichoke (K+ and N) were greater in RH and MS treatments, while sugar concentrations were higher in bare soil with respect to the other treatments. Conclusion: Hydromulching is a sustainable alternative to plastic mulching through the regulation of plant hydric status and soil moisture and fertility, thus improving yield and physical quality characteristics of artichoke heads, and maintaining their chemical and nutritional quality over bare soil.
Mechanism of novel enoxaparin sodium high viscosity bone cement reducing thrombosis by regulating the expression of CD40 in endothelial cells
Authors: Sang Linchao , Hao Kangning , Ding luobin , Shen Xiaoyu , Fu Dehao , Qi Xiangbei , Sun Hui 
Published: March 2022

Abstract
Objective: PMMA bone cement develop local thrombi, to solve that,our study found that ES-PMMA bone cement,a new kind of material,could reduce local thrombosis.We took a simple and reproducible animal model to confirm the reducing and preliminarily explored the molecular mechanism. Methods: On the basis of carotid artery vein extracorporeal shunt, the New Zealand rabbits were modeled into three groups: Sham group, PMMA group and ES-PMMS group. There were 10 rabbits in each group. Four hours after modeling,collecting the experimental samples,and comparing the amount of thrombosis between those groups. The collected vascular tissue samples were quantitatively detected for endothelial cell related thrombomodulin.Results: There were thrombosis in PMMA group and ES-PMMA grounp,which didn't exist in Sham group. The weight of thrombosis in PMMA group was 0.00732±0.00089g/cm, The weight of thrombosis in the ES-PMMA group was 0.00554±0.00077g/cm，P < 0.001. We found that the expression of CD40, a related protein that can regulate thrombosis in vascular endothelial cells, was significantly lower in the ES-PMMA group than that in the PMMA group using RT-qPCR as well as Western blot.Conclusion: Compared with PMMA bone cement, ES-PMMA bone cement can reduce local thrombosis by decreasing the expression of thrombus associated regulatory protein CD40 in vascular endothelial cells.
Early-stage colon cancer with high MALAT1 expression is associated with the 5-Fluorouracil resistance and future metastasis
Authors: Aksoy Secil Ak , Berrin Tunca , Tezcan Gulcin , Ozturk Ersin , Cecener Gulsah , UGRAS Nesrin , Yilmazlar Tuncay , YERCI Omer 
Published: March 2022

Abstract
Background: This study aimed to investigate the role of long noncoding RNA (LncRNA) expression profiles to predict relapse and 5-FU response in patients with stage I/II colon cancer (CC).Methods and Results: The expression level of 15 LncRNA was analyzed in stage I/II colon tumors of 126 CC patients. To confirm the findings in-vitro, 5FU-resistant HT29 cells were generated by subjecting HT-29 cells to the increasing concentrations of 5FU for 6 months. The 5FU resistance was observed in WST-1 and Annexin V analyses. The colony formation and wound healing assays were assessed to determine the metastatic properties of the cells. Expression levels of LncRNAs and mRNA of EMT-related genes were determined by RT-PCR. The role of LncRNA on metastasis and 5FU sensitivity were confirmed in pcDNA3.0-PTENP1 and si-MALAT1 expressed 5FU-resistant HT29 cell lineages.Results: High MALAT1 (p=0.0002) and low PTENP1 (p= 0.0044) expressions were significantly associated with 5-FU resistance and tumor relapse in stage I/II CC. The invasiveness and colony-forming characteristics of 5-FU-resistant cell lineages were higher as compared to the parent HT-29. Moreover, the expression of MALAT1 (p=0.0009) was increased while the expression of PTENP1 (p=0.0158) decreased in 5FU-resistant-HT-29 cells. Si-MALAT1 treatment increased cell sensitivity to 5FU, whereas it decreased invasive behaviors of 5 FU-resistant-HT-29 cells.Conclusion: MALAT1 may be a biomarker in predicting recurrence in early-stage CC. Our findings suggest that a cell-based therapy to target MALAT1 could be established for these patients to prevent metastasis and 5-FU resistance.