bluuebunny/crossref_metadata_2025_split huggingface dataset:
"CANDIDE" OU LA QUÊTE DU BONHEUR
Authors: Ferreira Lima Andrei Fernando 
Published: February 2022

Organisé autour d’un problème philosophique et littéraire bien déterminé, cet article vise à réévaluer la question du bonheur dans le récit Candide ou l’Optimisme (1759), de Voltaire. À partir de cette proposition, la présente analyse a pour objet la coordination de ce texte de Voltaire avec l’histoire des idées au siècle des Lumières, donc à renforcer les rapports entre l’oeuvre indiquée et d’autres textes – littéraires ou non – qui portent sur le thème du bonheur. La recherche récente en histoire intellectuelle, surtout les discussions autour de ce concept, montre l’importance de la pensée des Lumières dans la construction de grands idéaux modernes tels que la valeur de l’individu et les droits de l’homme, ce qui met en évidence un enjeu plus profond et plus vaste de la production voltairienne, notamment dans son conte Candide.
ALGUMAS TEMPESTADES ADENTRAM O PALÁCIO: CRISE, LEITURA E HISTORICIDADE EM TRÊS TRADUÇÕES DE MALLARMÉ
Authors: Micaelia Caroline 
Published: February 2022

Entre os últimos anos 1990 e os primeiros anos 2000 o curso interpretativo ligado à obra do francês Stéphane Mallarmé sofre uma leve perturbação: a valorização pela qual sua obra crítica passou nos últimos anos remodela, de certa maneira, não apenas o caminho percorrido pela recepção e pela tradução de seus trabalhos no Brasil, mas as próprias leituras que tem sido feitas, por toda parte, sobre o poeta. Em meio ao considerável fluxo de produções – nacionais e internacionais – que tocam essa reformulação crítica, os leitores brasileiros veem serem produzidas três traduções do mesmo texto mallarmeano, "Crise de vers" (1987), com brevíssimo intervalo entre publicações. Este trabalho pretende produzir, a partir de uma leitura historicizante da obra de Mallarmé e de uma concepção do texto que o compreende como construção movente, uma breve análise-comparada entre os projetos tradutórios envolvidos na transposição do referido poema-crítico ao português, sugerindo as possibilidades de interpretação depreendidas de cada tradução, com o objetivo de propor um indicativo de reflexão acerca do interesse que a crítica brasileira tem demonstrado à propósito da crise de vers.
«Le passeur d’eau» d’Émile Verhaeren: l’appel d’une poétique nouvelle
Authors: Cabral Maria de Jesus 
Published: February 2022

Dans l’itinéraire poétique d’Emile Verhaeren (1855-1916), « Le Passeur d’eau » – ainsi que toute la série des Villages illusoires – apparaît à plusieurs égards comme poème de transition, entre les premières œuvres du poète – la célèbre « Trilogie noire » toute empreinte du pessimisme schopenhauerien – et la poésie « sociale » des Campagnes hallucinées, nouveau pan d’une œuvre dorénavant ouverte à une humanité en pleine « révolution ». En partant d’une annotation de l’écrivain, l’article se propose d’analyser comment la thématique de l’eau, source de vie, associée à l’effort quotidien du passeur, à l’énergie humaine et à l’espoir sans cesse renouvelés, acquiert une dimension fortement symbolique. L’eau, reflet de la création où le geste du batelier au gouvernail de sa barque et celui du poète ne font qu’un, associe de façon prégnante la poétique et l’éthique, configurant une œuvre « follement » tournée vers l’avenir, au moment charnière du premier grand essor de la littérature et des arts en Belgique francophone.
Entrevista sobre o Simbolismo e o Decadentismo com Jean-Nicolas Illouz
Authors: Matangrano Bruno Anselmi , Illouz Jean-Nicolas 
Published: February 2022

Jean-Nicolas Illouz é professor de Literatura francesa do século XIX na Universidade Paris VIII, onde fez seu doutorado (1994). Autor dos livros Nerval. Le « rêveur en prose ». Imaginaire et écriture [Nerval. O “sonhador em prosa”. Imaginário e escritura] (1997) et Le Symbolisme (2004, réd. 2014), também coordenou várias edições críticas da obra de Gérard de Nerval e de obras científicas coletivas. Suas pesquisas são dedicadas aos estudos oitocentistas, sobre quatro eixos principais: trabalhos voltados para as questões da literatura simbolista e às obras de Nerval, aqueles que concernem as crises da prosa e do verso na modernidade e que dizem respeito às relações entre a literatura e as outras artes. Seu artigo « Nerval, poète renaissant » (2010) foi traduzido para o português por Marta Kawano, e publicado sob o título « Nerval, poeta do renascimento », no número 17-18 da revista Literatura e Sociedade (2012), da Universidade de São Paulo (USP). No presente número da revista Non Plus, dedicado ao tema “O Simbolismo na Literatura e nas Outras Artes”, o artigo « Les Impressionnistes et Stéphane Mallarmé » (2016) foi publicado em português, em tradução de Maria de Jesus Cabral (Universidade de Lisboa) e Bruno Anselmi Matangrano (Universidade de São Paulo) sob o título “Os Impressionistas e Stéphane Mallarmé”.
Do palco à flora, a pregnância de um imaginário - “A Inteligência das flores” de Maurice Maeterlinck
Authors: Quaghebeur Marc 
Published: February 2022

Tradução de Cristina Robalo Cordeiro (Universidade de Coimbra - FLUC)
Considera-se com frequência como um aparte a produção de Maurice Maeterlinck dedicada aos fatos naturais. A coerência dos livros deste ciclo, no interior do conjunto da obra, merece, no entanto, um olhar atento. Publicado na metade da vida do futuro Prêmio Nobel, L’Intelligence des fleurs [A Inteligência das Flores] (1907) prova ser assim bem mais que uma pura descrição botânica. O que o torna singular é o emaranhado de uma tal descrição natural com as assombrações do imaginário maeterlinckiano, que são além disso aquelas do idealismo finissecular. Este estudo faz surgir numerosos exemplos de descrições que se acreditaria tiradas dos dramas do autor de Pelléas.
Pesquisar (n)o crime: A transformação das dificuldades pragmáticas em prazer analítico
Authors: Biondi Karina 
Published: February 2022

Fazer pesquisa junto a pessoas que se dedicam a atividades criminosas tem certas particularidades e impõe algumas dificuldades. Neste artigo, abordarei duas delas a partir de situações vivenciadas em campo, a primeira relacionada com os riscos envolvidos na vida (e na pesquisa) do crime e a segunda, com minha condição de mulher pesquisando um universo povoado em grande parte por homens. No decorrer da exposição, apresentarei desafios, dilemas, reflexões, escolhas e tratamentos oferecidos em cada uma delas. Como espero deixar claro no decorrer do artigo, adversidades, situações de risco e percalços envolvendo relações de gênero podem, para além da produção de constatações ou de denúncias, dizer muito sobre as questões formuladas pelos interlocutores e os métodos que acionam para enfrentá-las, trazendo rendimentos analíticos importantes para a pesquisa.
Quando duas epidemias se encontram
Authors: Matos Silvana Sobreira de , Da Silva. Ana Cláudia Rodrigues 
Published: February 2022

Este artigo analisa os impactos da COVID-19 na vida das mulheres e crianças atingidas pelo Zika. Embora a emergência em Zika tenha finalizado, estas mulheres precisam lidar com uma “eterna emergência” para garantir sua sobrevivência e dos filhos. A partir de relatos enviados pelas mulheres construímos um panorama sobre a situação destas e das crianças em tempos de COVID-19, aprofundando questões como a dificuldade em fazer isolamento; efeitos da suspensão das terapias de reabilitação nas crianças; e a morte de crianças. Destacamos ainda que a Antropologia contribui para entendermos que epidemias globais são vivenciadas distintamente por grupos específicos, como nas mulheres e seus filhos com Síndrome Congênita do Zika Vírus que foram expostos à ansiedade, angústia, incerteza, medo, empobrecimento, adoecimento e morte em duas epidemias em menos de cinco anos.
Impacts of the Lagrangian Data Assimilation of Surface Drifters on Estimating Ocean Circulation during the Gulf of Mexico Grand Lagrangian Deployment
Authors: Sun Luyu , Penny Stephen G. , Harrison Matthew 
Published: February 2022

Abstract
Satellite-tracked in situ surface drifters, providing measurements of near-surface ocean quantities, have become increasingly prevalent in the global ocean observation system. However, the position data from these instruments are typically not leveraged in operational ocean data assimilation (DA) systems. In this work, the impact of an augmented-state Lagrangian data assimilation (LaDA) method using the local ensemble Kalman transform filter is investigated within a realistic regional ocean DA system. Direct positioning data of surface drifters released by the Consortium for Advanced Research on Transport of Hydrocarbon in the Environment during the summer 2012 Grand Lagrangian Deployment Experiment are assimilated using a Gulf of Mexico (GoM) configuration of the Modular Ocean Model, version 6, of the Geophysical Fluid Dynamics Laboratory. Multiple cases are tested using both 1/4° eddy-permitting and 1/12° eddy-resolving model resolutions: 1) a free running model simulation, 2) a conventional assimilation of temperature and salinity profile observations, 3) an assimilation of profiles and Lagrangian surface drifter positions, and 4) an assimilation of the profiles and derived Eulerian velocities. LaDA generally produces more accurate estimates of all fields compared to the assimilation of derived Eulerian velocities, with estimates of surface currents notably improving, when transitioning to 1/12° model resolution. In particular, LaDA produces the most accurate estimates of sea surface velocities under tropical cyclone conditions when Hurricane Isaac (2012) impacted the GoM. Further experiments applying a vertical localization while assimilating surface drifter positions improve the estimates of temperature and salinity below the mixed layer depth. Cases including the surface drifter positions in the DA show better Lagrangian predictability than the conventional DA.
Adoption of Technology Applications in Organized Retail Outlets in India:A TOE Model
Authors: Kumar Anil , Singh Rohit Kumar , Swain Swapnarag 
Published: February 2022

Purpose: The major intent of this study is to empirically explore the technology–organization–environment (TOE) factors that influence retail outlets’ adoption of technology applications in India. Methodology: In line with the objectives of the study, a conceptual model based on the TOE framework was proposed. A quantitative survey was conducted with organized retail outlets in Madhya Pradesh, India to validate the proposed model. The survey generated 134 valid responses. Partial least squares-structural equation modeling (PLS-SEM) was used to assess the research model. Findings: The findings elucidated that factors of the TOE framework significantly influence the technology adoption intention in the organized retail sector. It could be recommended that this framework is a robust instrument to envisage the adoption of technology applications in the retail sector. Research implications: The conceptual framework can be used by the retail sector in framing strategies for marketing that can enhance their potential customer base. It can also help to formulate policies which can act as a catalyst in adopting the technology applications. Practical implications: Retail vendors can use this model to increase their prospective customer base. Originality: The research contributes to the diversifying academic literature on technology application adoption by using factors within the TOE framework to explain organized retail outlets’ intention to adopt such technologies.
The Online Strength-Informed Acceptance and Commitment Therapy Among COVID-19-Affected Adolescents
Authors: Duan Wenjie , Kong Yansi , Bu He , Guan Qiujie , Chen Zheng , Luo Qiansheng , Zhang Jing 
Published: February 2022

Purpose: This study develops and investigates the changes in anxiety symptoms and quality of life (QoL) among participants of the online Strength-informed Acceptance and Commitment Therapy (SACT) across three tests. Methods: A small-scale, quasi-experiment with no control group was conducted. Repeated-measures analysis was employed to assess the changes of the three tests, which were the pre-experimental, post-test, and 3-month follow-up test. A total of 47 adolescents (ages 10–12) completed the 45-min intervention that lasted 10 weeks. Results: Compared with the pre-experimental, the post-test indicated significant anxiety symptoms reduction but not a statistically significant increase in QoL. The 3-month follow-up test indicated reduced anxiety symptoms and improved QoL compared with the pre-experimental. The with-in subject changes were substantial. Conclusions: The online SACT is a promising model to reduce anxiety symptoms and promote QoL among adolescents during the current COVID-19 pandemic, which show both short- and long-term benefit to the participants.
Development of a clinician guide for electronic medication adherence products in older adults
Authors: Patel Tejal , Ivo Jessica , McDougall Aidan , Lee Catherine , Chang Feng , Bauer Jillian , Pritchard Sarah 
Published: February 2022

Background/objectives: The ability to manage medications independently may be affected in older adults due to physical and cognitive limitations. Numerous electronic medication adherence products (eMAPs) are available to aid medication management. Unfortunately, there are no available guidelines to support clinicians in recommending eMAPs. The objective of this study was to create and validate a clinician tool to guide use of eMAPs. Methods: Pharmacists who previously tested the usability of the eMAPs participated in a focus group to provide feedback on 5 metrics of the clinician guide: unassisted task completion, efficiency, usability, workload and an overall eMAP score. Participants were asked semistructured questions on how they would use the tool to inform recommendations of medication aids to patients. The discussions were audio-recorded and transcribed verbatim and qualitatively analyzed. The clinician guide was modified to reflect feedback. Results: Five pharmacists (80% female, mean years of practice: 15.8) participated in the focus group. The clinician guide was modified by removing 2 metrics and adding an additional 8 metrics: maximum number of alarms, number of days the product can accommodate for based on a daily dosing regimen, price, monthly subscription, portability, locking feature, average time to set the device and number of steps required to set the device. The definition and calculation for unassisted task completion were modified. Additional instructions and specific patient case examples were also included in the final clinician guide. Conclusion: Since significant variability exists between eMAPs, it is imperative to have a tool for frontline clinicians to use when appropriately recommending the use of these products for medication management in older adults.
Osteochondral Allograft for Unsalvageable Osteochondritis Dissecans in the Skeletally Immature Knee
Authors: Tisano Breann , Ellis Henry B. , Wyatt Chuck , Wilson Philip L. 
Published: February 2022

Background: While an excellent option for osteochondral defects in the adult knee, fresh osteochondral allograft (FOCA) in the skeletally immature adolescent knee has been infrequently studied. Purpose: To compare radiographic and patient-reported outcomes (PROs) in skeletally mature and immature adolescents after FOCA in the knee for treatment of unsalvageable osteochondritis dissecans (OCD). Study Design: Cohort study; Level of evidence, 3. Methods: Included were 34 patients (37 knees) who underwent size-matched FOCA of the knee for unsalvageable OCD lesions. All patients were aged ≤19 years and had a minimum of 12 months of follow-up. Patient characteristics, lesion characteristics, reoperations, and PROs were evaluated and compared between patients with open physes (skeletally immature; n = 20) and those with closed physes (skeletally mature; n = 17). Graft failure was defined as the need for revision osteochondral grafting. Postoperative radiographs were analyzed at 1 year and the final follow-up for graft incorporation and classified as A (complete), B (≥50% healed), or C (<50% healed). Results: The mean patient age was 15.4 years (range, 9.6-17.6 years), and the mean follow-up was 2.1 years (range, 1-5.3 years). The mean graft size was 5.0 cm2 and did not differ significantly between the study groups. Patients with open physes were younger (14.7 vs 16.2 years; P = .002) and more commonly male (80% vs 35%; P = .008). At the 1-year follow-up, 85% of immature patients and 82% of mature patients had radiographic healing grades of A or B. Patients with open physes were more likely to achieve complete radiographic union at 1 year (65% vs 15%; P = .007) and demonstrated better Knee injury and Osteoarthritis Outcome Score (KOOS) Daily Living (96.8 vs 88.5; P = .04) and KOOS Quality of Life (87.0 vs 56.8; P = .01) at the final follow-up. Complications were no different in either group, and graft failure occurred in only 1 skeletally mature patient with a trochlear lesion. Conclusion: FOCA treatment for unsalvageable OCD in the young knee may be expected to yield excellent early results. Despite the presence of open physes and immature epiphyseal osteochondral anatomy, equivalent or improved healing and PRO scores compared with those of skeletally mature patients may be expected.
Oral anticoagulation versus antiplatelet therapy for secondary stroke prevention in patients with embolic stroke of undetermined source: A systematic review and meta-analysis
Authors: Hariharan Nikhil Nair , Patel Kashyap , Sikder Omaike , Perera Kanjana S , Diener Hans-Christoph , Hart Robert G , Eikelboom John W 
Published: February 2022

Purpose We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy and safety of direct oral anticoagulation (DOAC) compared with antiplatelet therapy for secondary stroke prevention in adult patients with embolic stroke of undetermined source (ESUS). Method We searched major databases (Embase, MEDLINE, CINAHL, CENTRAL, and Web of Science) for RCTs published until March 2021. The primary outcome was recurrent stroke, and the main safety outcomes were major bleeding and clinically relevant non-major bleeding (CRNB). We assessed risk of bias using the Cochrane Risk of Bias tool. We used a random-effects model to determine pooled risk ratios and 95% confidence intervals in the datasets and key subgroups. Findings Our search identified two RCTs, involving a total of 12,603 patients with ESUS. Anticoagulation with dabigatran or rivaroxaban compared with aspirin did not reduce the risk of recurrent stroke (RR, 0.96 [0.76–1.20]) or increase major bleeding (RR, 1.77 [0.80–3.89]) but significantly increased the composite of major or clinically relevant non-major bleeding (RR, 1.57 [1.26–1.97]). Prespecified subgroup analysis demonstrated consistent results according to age and sex. Additional post-hoc subgroup analyses demonstrated consistent results according to prior stroke and presence of a patent foramen ovale but suggested that DOACs reduced recurrent stroke in patients with an estimated glomerular filtration rate (eGFR) <50 and 50-80 ml/min but not in those with eGFR >80 ml/min (interaction P = 0.0234). Discussion/conclusion Direct oral anticoagulations are not more effective than aspirin in preventing stroke recurrence in patients with ESUS and increase bleeding. Registration PROSPERO ID: CRD42019138593
Cerebral vasculature exhibits dose-dependent sensitivity to thrombocytopenia that is limited to fetal/neonatal life
Authors: Farley Alison M. , Dayton Merle , Biben Christine , Stonehouse Olivia , Terreaux Antoine , Taoudi Samir 
Published: February 2022

Abstract
Whether increasing platelet counts in fetal and neonatal alloimmune thrombocytopenia (FNAIT) is effective at preventing intracerebral hemorrhage (ICH) has been a subject of debate. The crux of the matter has been whether thrombocytopenia is the major driver of ICH in diseases such as FNAIT. We recently demonstrated in mice that severe thrombocytopenia was sufficient to drive ICH in utero and in early neonatal life. It remains unclear what degree of thrombocytopenia is required to drive ICH and for how long after birth thrombocytopenia can cause ICH. By inducing a thrombocytopenic range, we demonstrate that there is a large buffer zone of mild thrombocytopenia that does not result in ICH, that ICH becomes probabilistic at 40% of the normal platelet number, and that ICH becomes fully penetrant below 10% of the normal platelet number. We also demonstrate that although the neonatal mouse is susceptible to thrombocytopenia-induced ICH, this sensitivity is rapidly lost between postnatal days 7 and 14. These findings provide important insights into the risk of in utero ICH with varying degrees of thrombocytopenia and into defining the developmental high-risk period for thrombocytopenia-driven ICH in a mouse model of FNAIT.
Mapping the prothrombin-binding site of pseutarin C by site-directed PEGylation
Authors: Üstok Fatma Işık , Huntington James A. 
Published: February 2022

Abstract
The prothrombinase complex processes prothrombin to thrombin through sequential cleavage at Arg320 followed by Arg271 when cofactor, factor (f) Va, protease, fXa, and substrate, prothrombin, are all bound to the same membrane surface. In the absence of the membrane or cofactor, cleavage occurs in the opposite order. For the less favorable cleavage site at Arg320 to be cleaved first, it is thought that prothrombin docks on fVa in a way that presents Arg320 and hides Arg271 from the active site of fXa. Based on the crystal structure of the prothrombinase complex from the venom of the Australian eastern brown snake, pseutarin C, we modeled an initial prothrombin docking mode, which involved an interaction with discrete portions of the A1 and A2 domains of fV and the loop connecting the 2 domains, known as the a1-loop. We interrogated the proposed interface by site-directed PEGylation and by swapping the a1-loop in pseutarin C with that of human fV and fVIII and measuring the effect on rate and pathway of thrombin generation. PEGylation of residues within our proposed binding site greatly reduced the rate of thrombin generation, without affecting the pathway, whereas those outside the proposed interface had no effect. PEGylation of residues within the a1-loop also reduced the rate of thrombin generation. The sequence of the a1-loop was found to play a critical role in prothrombin binding and in the presentation of Arg320 for initial cleavage.