bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between mission and performance of Christian faith-based hotels in Kenya
Authors: Muriithi Ruth Wanjiku 
Published: June 2022

The purpose of this study was to determine the relationship between the mission and Performance of Christian Faith-Based Hotels (CFBHs) in Kenya. Mission defines a significant long-term direction for the organization. There is little research that has been done on the relationship between the Mission and Performance of CFBHs in developing countries like Kenya. The objective of the study was to assess the relationship between the mission and Performance of Christian Faith-Based Hotels in Kenya. The study was guided by Denison’s organizational model and used the mixed methods approach guided by a cross-sectional survey research design. The population of this study was 1950 staff members, (72 managers and 1878 subordinate staff) from 24 Christian Faith-Based Hotels in Kenya. Stratified sampling was used where 322 subordinate staff were selected proportionate to the strata size while all the 72 managers were included in the study yielded a total of 394 respondents. Simple random sampling was used to select respondents in each stratum. Data were analyzed using descriptive and inferential statistics. The findings revealed that the dimensions of the mission had a significant influence on the performance of CFBHs in Kenya with a coefficient estimate of 0.325 and a critical ratio of 5.412 which is greater than the 1.96 Z score at a 5% level of significance. This study concluded that there is the relationship between mission and the performance of Christian Faith-Based Hotels in Kenya and recommends that more studies on Christian Faith-based Hotels be done.
A Hybrid Approach Based Diet Recommendation System using ML and Big Data Analytics
Authors: Lambay Muhib Anwar , Mohideen S.Pakkir 
Published: June 2022

Abstract
Recommendations are useful suggestions used by people from all walks of life. However, the usage of recommender systems became indispensable in modern applications. They are found in different domains such as E-commerce. Concerning the health care industry, recommendations play a very crucial role. This industry has significance as it is linked to the lives of people and their well-being. Human health depends on the diet followed. Keeping this fact in mind, in this paper, we investigated healthy diet recommendations. The recommender systems that are existing in healthcare-focused a little in this area. As food decides health, it is to be given paramount importance. In this paper, we proposed a hybrid mechanism based on Artificial Intelligence (AI) for big data analytics. Particularly we used Machine Learning (ML) for generating healthy diet recommendations. The proposed system is known as Hybrid Recommender System (HRS). It involves a hybrid approach with Natural Language Processing (NLP) and machine learning. An algorithm named Intelligent Recommender for Healthy Diet (IR-HD) is proposed to analyze data and provide healthy diet recommendations. IR-HD could generate recommendations on a healthy diet and outperform existing models. Python data science platform is used to implement the recommender system. The results of experiments showed that the system is capable of providing quality recommendations and it has performance improvement over the state of the art.
Rapid evidence synthesis to enable innovation and adoption in health and social care
Authors: Norman Gill , Wilson Paul , Dumville Jo , Bower Peter , Cullum Nicky 
Published: June 2022

Abstract
BackgroundThe rapid identification and adoption of effective innovations in healthcare is a known challenge. The strongest evidence base for innovations can be provided by evidence synthesis, but this is frequently a lengthy process and even rapid versions of this can be time-consuming and complex. In the UK, the Accelerated Access Review and Academic Health Science Network (AHSN) have provided the impetus to develop a faster pathway for identification and adoption of high value innovations in the English NHS. MethodsThe Greater Manchester Applied Research Collaboration (ARC-GM) developed a framework for a rapid evidence synthesis (RES) process, which is highly integrated within the innovation pipeline of the Greater Manchester AHSN and the associated health care and research ecosystem. The RES uses evidence synthesis approaches and draws on the GRADE Evidence to Decision framework to provide rapid assessments of the existing evidence and its relevance for the decision-making process. We implemented this in a real-time context of decision-making around adoption of innovative health technologies.ResultsKey stakeholders in the Greater Manchester decision-making process for healthcare innovations have found that our approach is both timely and flexible, making it a useful input to considerations of innovation for adoption. The RES also identifies limitations of the evidence base for innovations subsequently adopted for roll-out, informing the evaluations planned subsequent to implementation. There is substantial interest from other ARCs and AHSNs in implementing a similar process.ConclusionsThe RES framework we have implemented aims to combine transparency and consistency with flexibility and rapidity, to maximise utility in a real-time decision-making context for healthcare innovations.
A report of short term spontaneous regression of herniated lumbar disc.
Authors: UNNITHAN AJAYA KUMAR AYYAPPAN 
Published: June 2022

Abstract
Background and importance:Spontaneous regression of herniated lumbar discs over a course of time is well documented in literature. But the concomitant relief of symptoms is not seen always. The reports of regression within 3 months are a few. Kim ES et al reported about the peroperative identification of regression of an extruded disc fragment, during microdiscectomy 2 months after the magnetic resonance imgaging(MRI).Clinical presentation:A 58-year lady presented with backache, left leg pain, and weakness for 3 months. A magnetic resonance imaging ( MRI) scan of lumbosacral spine, taken three months back, showed L3-4 disc extrusion and canal stenosis and grade 1 listhesis at L5-S1. She had improvement with conservative treatment. But she had recurrence of symptoms 10 days back. Straight leg raising test was positive at 40 degree on left side. Dorsiflexion was grade 4 on left side. Sensations of touch and vibration were reduced in L4 dermatomal region.A repeat MRI scan was done to plan surgery. The disc extrusion at L3-4 had shrunk, with the residual listhesis at L5-S1. She was given gabapentin, methylcobolamine, and physiotherapy. She improved over 1 week.Conclusion:Spontaneous regression of herniated lumbar disc can occur within three months, without corresponding symptomatic relief. So it is better to do a repeat imaging before planning surgery for a patient with a prior diagnosis of disc herniation. Thus an unnecessary surgery can be avoided.
Key role for mitochondrial complex I assembly factor ECSIT and mitochondrial metabolism in controlling intestinal homeostasis and tumorigenesis by regulation of translation of YAP protein
Authors: Yang Shuo , Wang Bingwei , Moynagh Paul , Wen Shuang , Liu Lu , Wu Chunyan , Chen Min , Ma Chanyuan , Yang Yongbing , Hu Yingchao , Ma Chunmei , Jiang Yuying 
Published: June 2022

Abstract
The intestinal epithelium is the fastest renewing tissue in mammals and has extensive flexibility to adapt to different types of damage. The orderly expression and activation of the YAP protein is the initial step in driving intestinal development and crucial for intestinal regenerative responses and regulating intestinal homeostasis[1–4]. However, the regulatory mechanisms controlling this process are still unknown. Mitochondria are enriched in the intestinal epithelium and particularly along the crypt-villus axis [5]. But we have little known about the role of mitochondria in maintaining intestinal homeostasis and regulating cell fate determination. In this study, we discovered that mitochondrial complex I assembly was the top enriched mitochondrial gene ontology (GO) along the crypt-villus axis, and ECSIT, the core subunit of Mitochondrial Complex I Intermediate Assembly (MCIA) complex [6, 7], was the top up-regulated mitochondrial factor I factor among this ontology. Intestinal cell-specific ablation of ECSIT results in the dysregulation of intestinal epithelial cell (IEC) differentiation and the development of a spontaneous intestinal inflammation phenotype. Single-cell RNA sequencing also revealed that mice lacking ECSIT in intestinal cells displayed a distinct, early proliferation- type signature in all the major intestinal cells, which we term “-like” cells. The “-like” cells are marked by high YAP protein and downstream YAP transcriptional programs but have no alteration in Yap mRNA level. Mechanistically, we show that the absence of ECSIT in intestinal cells promotes YAP translation initiation through the upregulation of the eIF4F complex. This upregulation is due to the reduced DNA methylation in genes encoding eIF4A1 and eIF4G2. Such DNA methylation reduction is caused by the increased a-ketoglutarate (a-KG): succinate ratio activating Ten-eleven translocation (TET)-dependent DNA demethylation in ECSIT deficient cells. Moreover, decreased ECSIT expression in intestinal cells enhanced susceptibility to tumorigenesis in the context of dysregulated WNT signaling, and the expression of ECSIT is positively correlated with the survival of patients with colorectal cancer. Together, our results reveal a novel and important role of the mitochondrial complex I assembly factor ECSIT and mitochondrial metabolism in maintaining optimal intestinal homeostasis and controlling the development of tumorigenesis by critical regulation of the eIF4F-YAP signalling axis.
Uncertainty analysis in probabilistic design of detention rockfill dams using Monte-Carlo Simulation model and probabilistic frequency analysis of stability factors
Authors: Riyahi Mohammad Mehdi , Riahi-Madvar Hossien 
Published: June 2022

Abstract
The detention rockfill dams are of crucial significance in engineering flood control projects due to their minimal technical requirement, low cost, minimal environmental effects, self-automotive operation process. However, the reliable design of detention rockfill dams is a challenging topic because of the complex interaction between the coarse porous rockfill material and the flow, the non-Darcian flow in rockfills, their stability encountered with floods, reliable flood peak reduction, and safe flood discharge release to the downstream. The present study aims to investigate and evaluate the influence of aleatory uncertainties (i.e., rockfill material, hydrologic, hydraulic and geometric uncertainties) in the reliable design of detention rockfill dams. In this study a reliable design framework of detention rockfill dams is developed with a focus on the importance of stability of rockfill dams against the floods. The developed framework is used to acquire future detention rockfill dam design and modeling requirements. The stability analysis, neglected in previous literature of rockfill dams, is performed under the uncertain design parameters. The uncertainty of input parameters in model design consideration is investigated including the uncertainties of inlet hydrograph, volume-elevation relation of reservoir, non-Darcian stage-discharge equation in coarse rockfill material, non-linear flood routing in detention rockfill dams. The effects of design uncertainty sources on the stability of dam, safety factors of overturning, sliding and bearing, along with the hydraulic performance of the dam were tested. The results in the present study revealed that the uncertainties in the input parameters of the model can effectively produce uncertainties in the hydraulic performance of detention rockfill dams ranges from − 53.54 to + 110.11 percent. Finally, the effects of input uncertainties on the structural stability and safety factors in detention rockfill dams is investigated. The results revealed the safety factor against the sliding (SFS) has maximum dependencies with the uncertainties ranging − 32.63 to 87.81 percent. Using the Monte-Carlo Simulation (MCS) and fitting probability distribution functions to the safety factor histograms, the best PDF is selected by the goodness of fitting tests to determine the improvement percentages in safety factors. The MCS and uncertainty quantifications results in 88.3 percent in increasing the safety factors as a reliable methodology for stability design of detention rockfill dams. Thus, the study calls for reliable, certain and safe design of flood protection rockfill ponds.
The effect of Mir-181a-5p on the prognosis of LUAD patients through targeted regulation of GTSE1 expression
Authors: Yang Xitong 
Published: June 2022

Abstract
Studying the regulatory mechanism and clinical application of target genes in LUAD can further provide theoretical basis. LUAD expression data were downloaded from the UCSC database, miRNA data were obtained from the TCGA database, and DEGs were derived by analyzing expression data using R software. The genes associated with LUAD were then obtained by survival analysis, and among them, clear LUAD target genes were screened. In-depth analysis of the GEPIA database yielded differences in normal and tumor tissues of LUAD patients, while comparing DFS and OS of target genes in LUAD. The Relevant IncRNA was derived from mRNA and miRNA analysis, and the correlation between immune cell content and target gene copy number, as well as the correlation between target genes and immune checkpoint-related genes CD274, PDCD1 and CTLA4 were analyzed by Timer database. The results indicated that GTSE1 expression was significantly higher in LUAD tumor tissues than normal tissues, and the survival rates of OS and DFS were significantly lower in patients with high GTSE1 expression than in the low expression group. GSEA analysis of GTSE1 was mainly involved in LUAD through Biocarta ranms pathway. According to the R software, mir-181a-5p was the GTSE1 target miRNA and GTSE1 gene expression was negatively correlated with mir-181a-5p expression. In addition, GTSE1 was positively correlated with CD274, PDCD1, and CTLA4 immune checkpoints. The mir-181a-5p is a target miRNA of GTSE1 and mir-181a-5p expression is positively correlated with patient survival.
Coupling relationship between financial inclusion and agricultural green total factor productivity: Mechanism analysis and empirical research
Authors: Liu Guibo , Liang Chenglei , Gong Xiaoxian 
Published: June 2022

Abstract
Based on the panel data of 30 provinces in China from 2006 to 2019, this paper measures the coupling coordination degree of financial inclusion and agricultural green total factor productivity (AGTFP), and uses Dagum Gini coefficient and spatial feature analysis method to study the regional difference and spatial agglomeration state of coupling coordination degree. On this basis, it further discusses the impact of the improvement of the coupling co scheduling of financial inclusion and AGTFP on the urban-rural income gap. The results show that the overall level of financial inclusion and AGTFP is low, but both show a slow upward trend, and the degree of coupling and coordination between the two continues to improve, which has developed from the very low coordination stage to the primary coordination stage. The two show the characteristics of alternating changes of the relative lag of AGTFP and the relative lag of financial inclusion. At present, the main performance is the relative lag of financial inclusion. There are great regional differences in the coupling coordination degree of financial inclusion and AGTFP, but this regional difference is gradually narrowing; And its spatial pattern presents the characteristics of global positive autocorrelation and local spatial pattern evolution. Further discussion found that the improvement of the coupling and co scheduling of financial inclusion and AGTFP is conducive to narrowing the income gap between urban and rural areas. Therefore, in order to realize the sustainable development of agriculture, it is suggested to coordinate the relationship between financial inclusion and AGTFP.
Influence of temperature on fouling removal for pipeline based on eco-friendly ultrasonic guided wave technology
Authors: Huang Mingkun , Han Cong , An Yang , Qu Zhigang , Chen Chuanxian , Yin Wuliang 
Published: June 2022

Abstract
When industrial pipelines are used to transport production materials, the scale can easily form on the inner wall of a pipeline due to long-term contact with the liquid medium. Scaling in industrial pipelines is a common problem that poses a great threat to the production process and environmental protection. In this paper, the influence of temperature on the fouling removal process in pipes is studied. A finite element simulation model was established for guided wave propagation in pipes with different temperatures to obtain the acoustic pressure distribution along the pipes, showing that when the temperature increases, the acoustic pressure value on the solid-liquid surface of the pipes increases, and the cavitation threshold decreases. The experimental system for pipe descaling at different temperatures was established, when the temperature is from 20°C to 60°C, the descaling rate in the inner wall of the pipe far from the transducer is increased from 77.49–93.71%, the descaling rate in the inner wall of the pipe near the transducer is increased from 87.01–97.02%. The experimental results showed that the descaling performance is better when the pipeline temperature is higher.
Ultrafine Fully Vulcanized Natural Rubber Modified by Graft-Copolymerization with Styrene and Acrylonitrile Monomers
Authors: Longsiri Krittaphorn , Mora Phattarin , Peeksuntiye Watcharapong , Jubsilp Chanchira , Hemvichian Kasinee , Karagiannidis Panagiotis , Rimdusit Sarawut 
Published: June 2022

Abstract
This research aims to modify ultrafine fully vulcanized powdered natural rubber (UFPNR) prepared by emulsion graft-copolymerization with styrene (St) and acrylonitrile (AN) monomers onto deproteinized natural rubber (DPNR). The effects of monomer content and St/AN weight ratio on grafting efficiency and thermal stability of the developed DPNR-g-(PS-co-PAN) were investigated. The results showed that grafting efficiency was enhanced up to 87% with weight ratio St:AN 80:20. The obtained DPNR-g-(PS-co-PAN) was radiated by an electron beam at various doses, followed by a spray drying process to produce UFPNR. The obtained modified UFPNR particles irradiated at dose up to 300 kGy were relatively spherical with a particle size of approximately 4.4 µm. Furthermore, the degradation temperature of 5wt% loss (Td5) of UFPNR was found in the range of 349–356°C. The results revealed that the modified UFPNR is suitable as a toughening filler for a broader spectrum of polymers.
The Compilation and Analysis of the 2015 Input-output Table of Kyoto Prefecture for the Cultural Industry
Authors: Zhang Heming , Ishiro Taku 
Published: June 2022

Abstract
The rise of cultural industry is in the part facilitated by the rise of leisure and entertainment in the advanced industrialized economies. Recently western countries have been attaching importance to cultural industry and developing it as one of the growth strategies. Japan has also made numerous efforts to its cultural industry. Kyoto prefecture, as the ancient capital of Japan, is famous for its traditional culture, promoting the development of its cultural industry positively in these years. This paper is to analyze the impact and development status of Kyoto’s cultural industry, based on the compilation of the 2015 Input-output table of Kyoto prefecture with 110 sectors. First, the writer modified the 2015 IO table of Kyoto prefecture with 105 sectors to 110 sectors IO table. Second, some important IO analysis indexes derived from the matrix such as specialization coefficient, influence coefficient and sensitivity coefficient to show the characteristics of Kyoto’s cultural industry. Third, the writer compares the model of endogenization of consumption expenditure of household with the basic model of equivalence of the outputs, in order to analyze the impact on the more complex economic circle of cultural industry.
Numerical investigation and experimental validation of convective heat transfer in air square duct
Authors: Mhamdi Aymen , Driss Zied , Belghar Nourredine , Reis Paulo , Bezazi Abderazak , Guerira Belhi , Kchaou Hedi 
Published: June 2022

Abstract
The present paper introduces the impact of the turbulence model and the meshing effect on the airflow characteristics inside a square duct. The analysis in this study is done with the commercial software "ANSYS FLUENT 17.0" using the finite volume method. In this application, several numerical parameters such as the convective heat gain, the magnitude velocity, the temperature, the static pressure and the turbulence characteristics are analysed in order to select the most appropriate model. To ensure the accuracy of the numerical findings, we investigated the influence of meshing on CFD results in order to select the most appropriate mesh with the shortest calculated time. We also looked on the impact of the turbulence model on the aerodynamics properties of the considered square air duct.
Ultrasound-Targeted Microbubble Destruction-Mediated Bax Silencing Inhibits Acute Rejection Following Heart Transplantation
Authors: Xu Jing , Jin Jia Mei , Li Gang , Zong Ming , Tao Yi Rao , Chen Ming , Zhang Yu Hui , Cao Hao 
Published: June 2022

Abstract
Background: Ultrasound‑targeted microbubble destruction (UTMD) has been developed as a promising approach for organ‑ and tissue‑specific gene or drug delivery. The aim of the present study was to explore the role of UTMD‑mediated Bax gene silencing in acute rejection(AR) response after heart transplantation(HT).Methods: Bax-short hairpin RNA (shRNA) bound with polyethyleneimine (PEI) and microbubbles(MBs) were synthesized and effective ultrasound-targeted delivery of Bax-shRNA/PEI into rat cardiomyocyte H9c2 confirmed in vitro. Based on these observations, three transplant rat models were tested： ①Allograft (ALLO); ② ALLO+cyclosporine(CsA); and ③ALLO+UTMD+Bax-shRNA/PEI. The protein expression of Bax gene was detected through Western blot analysis. The pathological examination and survival time of cardiac allografts were also evaluated.Results: Bax protein expression was significantly inhibited in ALLO+UTMD+Bax-shRNA/PEI group compared to the other two groups(p<0.01). At 6 days post HT, the ALLO+UTMD+Bax-shRNA/PEI group had Grade II rejection or less inflammatory infiltration and myocyte damage using International Society For Heart and Lung Transplantation grading, compared to Grade IIIB or IV in ALLO group and Grade II or III in ALLO+CsA group.The survival time of allografts in ALLO+UTMD+Bax-shRNA/PEI group was(16.21±5.01)days, which was obviously longer than that in ALLO (p < 0.05) and ALLO+CsA(p < 0.01) group.Conclusions: UTMD mediated Bax gene inhibition with shRNA/PEI can prevent acute cellular rejection and improve survival time of the grafted heart in the early post-transplant period. These findings may provide a new strategy for gene therapy in patients after HT.