bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Pengaruh Digital Marketing Terhadap Keputusan Pembelian Grabfood Di Kecamatan Kebon Jeruk
Authors: Aji Kelvin Bayu 
Published: January 2022

Grab perusahaan jasa terkenal yang berasal dari singapura yang memiliki layanan pesan antar makanan yakni Grabfood yang berkembang pesat. Pesatnya perkembangan dari Grabfood masih kalah jika bersaing di Indonesia terutama dengan pesaing sejenisnya. Tujuan dari penelitian yakni untuk menganalisis dan membuktikan pengaruh search engine marketing, social media marketing, online public relation terhadap keputusan pembelian konsumen Grabfood. Jenis data yang digunakan adalah jenis data kuantitatif dengan populasi yakni konsumen Grabfood di Kecamatan Kebon Jeruk. Dengan sampel 75 responden yang pernah menggunakan jasa layanan Grabfood dan non purposive sampling sebagai metodenya. teknik analisis menggunakan Partial Least Square (PLS). Hasil yang didapatkan yaitu variabel search engine marketing, social media marketing, online public relation berpengaruh dan signifikan terhadap keputusan pembelian konsumen. Berdasarkan nilai koefisien determinasi dijelaskan bahwa search engine marketing, social media marketing dan online public relation mempengaruhi keputusan pembelian pada konsumen Grabfood di wilayah Kecamatan Kebon Jeruk sebesar 0.446 atau 44.6%.
Does Cultural Hofstede dimension "Indulgence versus Restraint" impact the Corporate Performance
Authors: Aleqedat Houda Qasim 
Published: January 2022

Jordan, as an Arab country located in the Middle East, began to pay attention to change. Jordanian society began to move from an old-style state to a contemporary state. Where globalization had a significant impact on culture, either in terms of individual culture and organizational culture. On the other hand, many studies emphasized that culture through its dimensions has an important role in influencing the corporate atmosphere or corporate social responsibility, as well as affecting the financial performance of companies. Moreover, the literature indicates that cultural dimensions influence the conduct of individuals and the performance of firms. .
The literature indicated that there are different dimensions of culture, including Hofstede's dimensions of culture, which are Power Distance Index; Individualism versus collectivism; Masculinity versus Femininity; Uncertainty Avoidance index; Long-versus Short- Term Orientation; Indulgence versus Restraint. This study focused on the Indulgence versus Restraint dimension, as a recent dimension, where through the literature it can be predicted the existence of a critical role for the indulgence dimension on performance. After reviewing the literature related to the Indulgence dimension, it was found that there is a shortage and almost no local studies conducted in Jordan regarding the Indulgence versus Restraint dimension. Since this dimension is new, this paper stresses the importance of more research on this subject to expand the local literature on Indulgence and its impact on the performance in the Jordan context and compare it with other countries in order to provide important and useful results for the policymakers.
Peningkatan Pengetahuan Masyarakat Cikupa Terhadap Tuberkulosis
Authors: Atzmardina Zita 
Published: January 2022

Latar belakang Tuberkulosis (TB) masih menjadi salah satu masalah kesehatan di masyarakat yang dapat menimbulkan kesakitan, kecacatan dan kematian yang tinggi sehingga perlu dilakukan upaya penanggulangan. Tuberkulosis merupakan penyakit menular yang disebabkan oleh Mycobacterium tuberculosis yang dapat menyerang paru dan organ lainnya. Infeksi akan terjadi ketika orang lain secara sengaja maupun tidak sengaja menghirup udara yang mengandung percikan dahak infeksius tersebut.
Tujuan Kegiatan pengabdian yang kami lakukan ini bertujuan bisa meningkatkan pengetahuan masyarakat di Cikupa sehingga dapat mengubah sikap dan perilaku masyarakat yang akhirnya diharapkan dapat menurunkan angka kejadian tuberkulosis.
Metode Kegiatan pengabdian yang kami lakukan ini dengan memberikan penyuluhan kepada warga yang datang ke Puskesmas Cikupa. Sebelum kegiatan berlangsung, kami melakukan pre-test kepada warga yang hadir, kemudian penyuluhan dilakukan dengan media Power Point yang berisikan pengertian, penyebab, faktor risiko, cara penularan, gejala, pengobatan, dan cara pencegahan tuberkulosis. Setelah penyuluhan dibagikan leaflet dan dilakukan demonstrasi cara etika batuk serta penggunaan masker yang baik dan benar, kemudian kegiatan ditutup dengan post-test
Hasil Hasil pada 30 responden didapatkan adanya perbedaan rata-rata yang signifikan (P<0.001) antara nilai pretest dan postest dengan nilai mean difference sebesar 16,00 (SD 12,76). Hasil dari demonstrasi yang dilakukan juga baik dengan dilihat dari warga yang terpilih untuk melakukan demonstrasi ulang dapat mengulang cara etika batuk serta penggunaan masker yang baik dan benar.
Kesimpulan Kegiatan intervensi yang kami lakukan berjalan dengan baik dan sesuai rencana karena didapatkan peningkatan hasil nilai pre test dan post test sehingga kegiatan seperti ini dapat terus berlangsung untuk memberikan dampak khususnya penurunan kasus Tuberkulosis.
Kata kunci Tuberkulosis, Etika Batuk, Masker
The Economic Effects of Free Trading Policies Within an Integrated Economy Between Philippines and the Asean-6 Member States
Authors: Pagco Moises Louis , VALERA Aeron John , Buot Lance David , Camaro Peter Jeff 
Published: January 2022

The analysis of the effects that free trade has within the context of the Philippines and its fellow co-members within the Association of Southeast Asian Nations was purposed as a conduit for greater insight on trade relations between the nations of what is being considered as a fast-growing unified economy. In a more specific lens, the paper identifies how the Philippines and its fellow nations within the bloc conduct free trade while also carefully examining the number of goods that are being imported and exported. The study will use a Quantitative research design to find the changes in exports and imports as well as to point out the association between the dependent and independent variables. The study also determines the effect of trade policy. The research is a cross-country study exclusive to ASEAN-6, namely Brunei, Indonesia, Malaysia, Singapore, Thailand and the Philippines, and the period of the study is from the year 1993 – 2015. The researchers used Ordinary Least Squares and showed a high degree of predictability between the dependent and independent variables. The findings confirm that there exists a significant degree of negative correlation between the import and inflation, tariff and FDI. On the other hand, there is a significant positive correlation between the FDI and import of 4 ASEAN countries, namely Brunei, Singapore, Thailand, and Indonesia, besides a negative correlation between FDI and import of Malaysia. While the tariff and inflation of the Philippines and imports come up with a negative relationship, so this brings us to the conclusion that the independent variables are affected by the policy of free trade but for the good of the economies of the countries involved. With the result of the study, it is expected that further examination of this topic will expound more as the zeitgeist affecting the ASEAN bloc continues to tentatively change. The policy-makers should build an inclusive and sustainable trading system by identifying priorities for improvement and clarifying the design of new trade rules. The policy-makers should also come up with indicators, trade facilitation performance of different countries, information on the level of trade in services restrictiveness, and also records on export restrictions.
Evaluación de infográficos durante el primer año de pandemia en 'El País Digital' (2020-2021)
Authors: Muñoz Fernández Natalia , Lucas Barcia Elisa 
Published: January 2022

La comunicación eficaz de los riesgos es indispensable para gestionar los brotes epidémicos; consecuentemente, las noticias y cifras sobre la COVID-19 se convirtieron en una necesidad constante desde principios de 2020. En este sentido, los infográficos suponen una poderosa herramienta para transmitir este tipo de información. El presente trabajo analiza el primer año de pandemia a través de los infográficos publicados por El País Digital para evaluar su uso en la comunicación de esta crisis sanitaria. Mediante el análisis de contenido, se estudian temas y enfoques de los artículos, el peso de los infográficos respecto al texto, los tipos y subtipos de infográficos utilizados, y sus grados y tipos de interacción, así como la evolución de estas variables a lo largo del periodo de estudio. Los resultados determinan que el contenido tipo del periodo analizado es un artículo de temática basada en datos, abordado desde un enfoque analítico/interpretativo, con protagonismo compartido entre infográficos y texto, y que incluye gráficos de líneas sin ningún tipo de interactividad.
Identification and Validation of Constructing the Prognostic Model With Four DNA Methylation-Driven Genes in Pancreatic Cancer
Authors: Chen Guangyu , Long Junyu , Zhu Ruizhe , Yang Gang , Qiu Jiangdong , Zhao Fangyu , Liu Yuezhe , Tao Jinxin , Zhang Taiping , Zhao Yupei 
Published: January 2022

Background: Pancreatic cancer (PC) is a highly aggressive gastrointestinal tumor and has a poor prognosis. Evaluating the prognosis validly is urgent for PC patients. In this study, we utilized the RNA-sequencing (RNA-seq) profiles and DNA methylation expression data comprehensively to develop and validate a prognostic signature in patients with PC.Methods: The integrated analysis of RNA-seq, DNA methylation expression profiles, and relevant clinical information was performed to select four DNA methylation-driven genes. Then, a prognostic signature was established by the univariate, multivariate Cox, and least absolute shrinkage and selection operator (LASSO) regression analyses in The Cancer Genome Atlas (TCGA) dataset. GSE62452 cohort was utilized for external validation. Finally, a nomogram model was set up and evaluated by calibration curves.Results: Nine DNA methylation-driven genes that were related to overall survival (OS) were identified. After multivariate Cox and LASSO regression analyses, four of these genes (RIC3, MBOAT2, SEZ6L, and OAS2) were selected to establish the predictive signature. The PC patients were stratified into two groups according to the median risk score, of which the low-risk group displayed a prominently favorable OS compared with the high-risk group, whether in the training (p &lt; 0.001) or validation (p &lt; 0.01) cohort. Then, the univariate and multivariate Cox regression analyses showed that age, grade, risk score, and the number of positive lymph nodes were significantly associated with OS in PC patients. Therefore, we used these clinical variables to construct a nomogram; and its performance in predicting the 1-, 2-, and 3-year OS of patients with PC was assessed via calibration curves.Conclusion: A prognostic risk score signature was built with the four alternative DNA methylation-driven genes. Furthermore, in combination with the risk score, age, grade, and the number of positive lymph nodes, a nomogram was established for conveniently predicting the individualized prognosis of PC patients.
Characterization of m6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Infiltration in Ovarian Cancer
Authors: Luo Yihong , Sun Xiang , Xiong Jian 
Published: January 2022

Introduction: Studies have demonstrated the epigenetic regulation of immune responses in various cancers. However, little is known about the RNA N6-methyladenosine (m6A) modification patterns of the microenvironment (TME) cell infiltration in ovarian cancer (OC).Methods: We evaluated the correlation between m6A modification patterns and TME cell infiltration based on 459 OC samples from the Cancer Genome Atlas and Gene-Expression Omnibus database. We constructed an m6Ascore system to quantify m6A modification patterns using principal component analysis.Results: Based on unsupervised clustering, three m6A modification patterns were identified. Gene set variation analysis showed that the antigen presentation signal pathway, the NOTCH signaling pathway, and the metabolism-related pathway differed significantly across m6A modificaiton patterns. The m6Ascore is closely correlated with TME cell infiltration. OC patients with lower m6Ascores had worse outcomes. There was better risk stratification with combined m6Ascore and tumor mutation burden. The responses to immune checkpoint inhibitor treatment significantly differed between high and low m6Ascore groups.Conclusion: M6A modification plays an essential role in TME cell infiltration in OC. Evaluating the m6A modification patterns in OC patients could enhance our understanding of TME infiltration characterization and guide immunotherapy strategies.
Multistep Structural and Chemical Evaluation of Sugarcane Baggase, Pretreated With Alkali for Enhancing the Enzymatic Saccharification by Cellulase and Xylanase of the Pseudomonas sp. CVB-10 (MK443365) and Bacillus paramycoides T4 (MN370035) Mix-Culture System
Authors: Tiwari Soni , Yadav Janardan , Gaur Rajeeva , Singh Ranjan , Verma Tuhina , Yadav Jay Shanker , Pandey Prabhash Kumar , Rath Srikanta Kumar 
Published: January 2022

The enzymatic saccharification of sugarcane bagasse was significantly increased by alkali pretreatment under mild conditions. The effectiveness of different concentrations of alkali and acid pretreatment of sugarcane bagasse for improving the enzymatic saccharification of lignocellulose has been evaluated. The sugarcane bagasse was characterized to contain 39.52% celluloses, 25.63% hemicelluloses, and 30.36% lignin. After that, sugarcane bagasse was pretreated with 5 and 10% of H2SO4 and NaOH at 121°C for 60 min. FTIR, XRD, and SEM analyses also showed significant molecular and surface structure changes of the sugarcane bagasse with 10% NaOH. Maximum saccharification was 489.5 mg/g from 10% NaOH pretreatment followed by 322.75, 301.25, and 276.6 mg/g from 10% H2SO4, 5% NaOH, and 5% H2SO4, respectively, which were 55.1, 32.0, 27.1, and 20.6 times higher than the that of the control. Cellulase and xylanase produced by Pseudomonas sp. CVB-10 (MK443365) and Bacillus paramycoides T4 (MN370035) were used to hydrolyze the pretreated bagasse, and the optimal condition was determined to be 30 h of the enzymatic reaction with the 3:1 ratio of enzymes under the temperature of 55°C, pH 5.0, and substrate concentration of 3%, leading to celluloses and hemicelluloses conversion in the enzymatic hydrolysis/saccharification that is more proficient.
Age-Related Risk Factors and Complications of Patients With COVID-19: A Population-Based Retrospective Study
Authors: Zhang Han , Wu Yingying , He Yuqing , Liu Xingyuan , Liu Mingqian , Tang Yuhong , Li Xiaohua , Yang Guang , Liang Gang , Xu Shabei , Wang Minghuan , Wang Wei 
Published: January 2022

Objective: To study the differences in clinical characteristics, risk factors, and complications across age-groups among the inpatients with the coronavirus disease 2019 (COVID-19).Methods: In this population-based retrospective study, we included all the positive hospitalized patients with COVID-19 at Wuhan City from December 29, 2019 to April 15, 2020, during the first pandemic wave. Multivariate logistic regression analyses were used to explore the risk factors for death from COVID-19. Canonical correlation analysis (CCA) was performed to study the associations between comorbidities and complications.Results: There are 36,358 patients in the final cohort, of whom 2,492 (6.85%) died. Greater age (odds ration [OR] = 1.061 [95% CI 1.057–1.065], p &lt; 0.001), male gender (OR = 1.726 [95% CI 1.582–1.885], p &lt; 0.001), alcohol consumption (OR = 1.558 [95% CI 1.355–1.786], p &lt; 0.001), smoking (OR = 1.326 [95% CI 1.055–1.652], p = 0.014), hypertension (OR = 1.175 [95% CI 1.067–1.293], p = 0.001), diabetes (OR = 1.258 [95% CI 1.118–1.413], p &lt; 0.001), cancer (OR = 1.86 [95% CI 1.507–2.279], p &lt; 0.001), chronic kidney disease (CKD) (OR = 1.745 [95% CI 1.427–2.12], p &lt; 0.001), and intracerebral hemorrhage (ICH) (OR = 1.96 [95% CI 1.323–2.846], p = 0.001) were independent risk factors for death from COVID-19. Patients aged 40–80 years make up the majority of the whole patients, and them had similar risk factors with the whole patients. For patients aged &lt;40 years, only cancer (OR = 17.112 [95% CI 6.264–39.73], p &lt; 0.001) and ICH (OR = 31.538 [95% CI 5.213–158.787], p &lt; 0.001) were significantly associated with higher odds of death. For patients aged &gt;80 years, only age (OR = 1.033 [95% CI 1.008–1.059], p = 0.01) and male gender (OR = 1.585 [95% CI 1.301–1.933], p &lt; 0.001) were associated with higher odds of death. The incidence of most complications increases with age, but arrhythmias, gastrointestinal bleeding, and sepsis were more common in younger deceased patients with COVID-19, with only arrhythmia reaching statistical difference (p = 0.039). We found a relatively poor correlation between preexisting risk factors and complications.Conclusions: Coronavirus disease 2019 are disproportionally affected by age for its clinical manifestations, risk factors, complications, and outcomes. Prior complications have little effect on the incidence of extrapulmonary complications.
Nomogram to Predict Intensive Care Following Gastrectomy for Gastric Cancer: A Useful Clinical Tool to Guide the Decision-Making of Intensive Care Unit Admission
Authors: Pan Tao , Chen Xiao-long , Liu Kai , Peng Bo-qiang , Zhang Wei-han , Yan Meng-hua , Ge Rui , Zhao Lin-yong , Yang Kun , Chen Xin-zu , Hu Jian-kun 
Published: January 2022

BackgroundWe aimed to generate and validate a nomogram to predict patients most likely to require intensive care unit (ICU) admission following gastric cancer surgery to improve postoperative outcomes and optimize the allocation of medical resources.MethodsWe retrospectively analyzed 3,468 patients who underwent gastrectomy for gastric cancer from January 2009 to June 2018. Here, 70.0% of the patients were randomly assigned to the training cohort, and 30.0% were assigned to the validation cohort. Least absolute shrinkage and selection operator (LASSO) method was performed to screen out risk factors for ICU-specific care using the training cohort. Then, based on the results of LASSO regression analysis, multivariable logistic regression analysis was performed to establish the prediction nomogram. The calibration and discrimination of the nomogram were evaluated in the training cohort and validated in the validation cohort. Finally, the clinical usefulness was determined by decision curve analysis (DCA).ResultsAge, the American Society of Anesthesiologists (ASA) score, chronic pulmonary disease, heart disease, hypertension, combined organ resection, and preoperative and/or intraoperative blood transfusions were selected for the model. The concordance index (C-index) of the model was 0.843 in the training cohort and 0.831 in the validation cohort. The calibration curves of the ICU-specific care risk nomogram suggested great agreement in both training and validation cohorts. The DCA showed that the nomogram was clinically useful.ConclusionsAge, ASA score, chronic pulmonary disease, heart disease, hypertension, combined organ resection, and preoperative and/or intraoperative blood transfusions were identified as risk factors for ICU-specific care after gastric surgery. A clinically friendly model was generated to identify those most likely to require intensive care.
Early Postoperative Serum Carcinoembryonic Antigen Is a Stronger Independent Prognostic Factor for Stage II Colorectal Cancer Patients Than T4 Stage and Preoperative CEA
Authors: Fenqi Du , Yupeng Liu , Qiuju Zhang , Chao Yuan , Wenjie Song , Tianyi Xia , Junnan Guo , Weinan Xue , Xiufeng Jiang , Junge Bai , Chenyang Jia , Hua Xi , Yien Li , Xuefeng Bai , Yanlong Liu 
Published: January 2022

BackgroundSerum carcinoembryonic antigen (CEA) is an important biomarker for diagnosis, prognosis, recurrence, metastasis monitoring, and the evaluation of the effect of chemotherapy in colorectal cancer (CRC). However, few studies have focused on the role of early postoperative CEA in the prognosis of stage II CRC.MethodsPatients with stage II CRC diagnosed between January 2007 and December 2015 were included. Receiver operating characteristic (ROC) curves were used to obtain the cutoff value of early postoperative CEA, CEA ratio and CEA absolute value. The areas under curves (AUCs) were used to estimate the predictive abilities of the CEA and T stage. The stepwise regression method was used to screen the factors included in the Cox regression analysis. Before and after propensity score (PS) - adjusted Cox regression and sensitivity analysis were used to identify the relationship between early postoperative CEA and prognosis. Meta-analysis was performed to verify the results. Kaplan-Meier survival curves were used to estimate the effects of CEA on prognosis.ResultsWe included 1081 eligible patients. ROC curves suggested that the cutoff value of early postoperative CEA was 3.66 ng/ml (P &lt;0.001) and the AUC showed early postoperative CEA was the most significant prognostic marker in stage II CRC (P = 0.0189). The Cox regression and sensitivity analysis before and after adjusting for PS both revealed elevated early postoperative CEA was the strongest independent prognostic factor of OS, DFS, and CSS (P &lt; 0.001). Survival analysis revealed that patients with elevated early postoperative CEA had lower OS (53.62% VS 84.16%), DFS (50.03% VS 86.75%), and CSS (61.77% VS 90.30%) than patients with normal early postoperative CEA (P &lt; 0.001). When the postoperative CEA was positive, the preoperative CEA level showed no significant effect on the patient’s prognosis (all P-values were &gt; 0.05). Patients with a CEA ratio ≤0.55 or CEA absolute value ≤-0.98 had a worse prognosis (all P-values were &lt; 0.001). Survival analysis suggested that adjuvant chemotherapy for stage II CRC patients with elevated early postoperative CEA may improve the CSS (P = 0.040).ConclusionsEarly postoperative CEA was a better biomarker for prognosis of stage II CRC patients than T stage and preoperative CEA, and has the potential to become a high-risk factor to guide the prognosis and treatment of stage II CRC patients.