bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Biomarker of Collagen Degradation Can Identify Patients Affected With Both Axial Spondyloarthritis and Crohn Disease
Authors: Nielsen Signe Holm , Stahly Andrew , Regner Emilie H. , Bay-Jensen Anne-Christine , Karsdal Morten A. , Kuhn Kristine A. 
Published: June 2022

ObjectiveChronic inflammatory arthritis is a hallmark of axial spondyloarthritis (axSpA), where coexistence of Crohn disease (CD) is prominent. We investigated the association between biomarkers of collagen degradation in healthy controls (HCs) and in patients with axSpA, CD, and CD and axSpA overlap (CD-axSpA), with the aim to investigate the ability of the biomarkers to identify patients with CD-axSpA.MethodsPatients with axSpA who fulfilled Assessment of Spondyloarthritis international Society criteria (n = 13), had biopsy-proven CD (n = 14), had CD-axSpA (n = 10), and HCs (n = 11) undergoing standard-of-care colonoscopies were included in the study. The collagen biomarkers measuring type III, IV, VI and X collagen (C3M, C4M, C6M, and C10C, respectively) were measured in plasma samples from all subject groups. Statistical analysis was performed using an ANCOVA adjusted for age, an area under the receiver-operating characteristic (AUROC) curve analysis, and Spearman correlation.ResultsC4M was significantly higher in patients with CD-axSpA overlap compared to axSpA, CD, and HCs (allP< 0.001). In an AUROC analysis, C4M showed a complete separation between the patients with CD-axSpA overlap compared to HC, axSpA and CD with an area under the curve (AUC) = 1.00 (P< 0.001). No differences were found between the patient groups for C3M, C6M, and C10C. No correlations were found between the collagen biomarkers and C-reactive protein, Bath Ankylosing Spondylitis Disease Activity Index, Simple Clinical Colitis Activity Index, or Harvey-Bradshaw Index scores.ConclusionDegradation of type IV collagen quantified by C4M showed a complete separation of patients with CD-axSpA overlap, compared to axSpA, CD, and HCs, and indicates excessive collagen degradation and epithelial turnover. This biomarker could potentially be used to identify patients affected by both manifestations and to guide treatment decisions.
Biological parameters, ecology and population trends of the Mediterranean endemic skate, Raja polystigma, in the Balearic Islands
Authors: Ferragut-Perello Francesca , Valls Maria , Cortes-Pujol Miquel A. , Ramirez-Amaro Sergio , Guijarro Beatriz , Ordines Francesc 
Published: June 2022

Elasmobranchs are a vulnerable group that has been overexploited for almost half a century in the Mediterranean. However, few elasmobranch species have been assessed because information on their basic biological parameters is lacking for most species. Raja polystigma is a poorly studied endemic skate in the Mediterranean. The aim of this work is to determine some basic life history parameters of this skate in the Balearic Islands. Data were collected from commercial catches and during MEDITS surveys. Total length varied from 17 to 59 cm for both sexes, with a higher proportion of females than males. Allometric and morphometric relationships differed between sexes, females being heavier for a given size. Females matured at a larger size than males (L50 47.7 cm and 38.4 cm, respectively). Potential fecundity ranged between 11 and 45 yolked oocytes per female, and spawning was observed mainly during winter and spring. Persistent hotspots of adults and juveniles were detected on the shallow shelf off the northwest of Mallorca and east of Menorca, with adults being found mainly in the shallow and juveniles in deeper areas. Time series of abundance and frequency of appearance showed stable trends throughout the study period (2003-2018).
Physical activity promotion in persons with spinal cord injuries: Barriers and facilitators in low-resource communities
Authors: Vermaak Candace , Ferreira Suzanne , Terblanche Elmarie , Derman Wayne 
Published: June 2022

Background: A spinal cord injury is a devastating and life-changing event that presents the affected individual with multiple challenges throughout life. Physical activity can help mitigate some of these challenges; however, in low-resource communities where opportunities for physical activity are scarce, these challenges are often exacerbated and multiple.Objective: This study aimed to identify the barriers and facilitators to physical activity, specifically in individuals with spinal cord injuries, in low-resourced communities.Methods: A total of 57 adults ( 20 years) with a spinal cord injury living in the Western Cape, South Africa completed the self-developed research questionnaire.Results: A total of 289 barriers and 290 facilitators were reported. The most frequently reported barriers were lack of transport (n = 35), impairment type (n = 32), lack of trained volunteers and appropriate programmes (n = 19 each) and lack of information received from therapists following discharge (n = 10). The most frequently reported facilitators were support from family (n = 38), the ‘enjoyment’ of physical activity and the fact that ‘it made me feel good’ (n = 37); safe and accessible facilities were reported by 25 participants and 12 participants reported that higher-quality programmes and better-trained staff would help them to be more physically active.Conclusion: Individuals with a spinal cord injury face many barriers in being physically active. Yet it is evident that people with spinal cord injuries in low-resourced communities are eager to participate and improve their health and physical function. However, this will only realise if practitioners reduce the barriers to access, provide relevant training to staff and volunteers, educate their patients about the importance of physical activity post discharge, and create tailored programmes in safe and accessible community facilities.
La proyección social de las instituciones de educación superior y el fortalecimiento del liderazgo comunitario
Authors: Pico Macías Malena Elizabeth , Lorenzo Jaramillo Gustavo Alberto , Bello Sabado Borisse Javier , Chaves Franco Jorge Alberto 
Published: June 2022

La Proyección Social como función sustantiva de las Instituciones de Educación Superior (IES) es la vía para desarrollar y fortalecer el trabajo en las comunidades, para formar a sus líderes comunitarios y establecer un adecuado y efectivo vínculo de la institución con su entorno. En la relación de las IES con la comunidad cobra especial atención el papel de los líderes comunitarios, los cuales tiene un rol de gran relevancia en sus comunidades, este recurso humano puede ser abordado por estas instituciones a través de programas de formación, asesorías, capacitación en la formulación de proyectos sociales, de emprendimiento y técnicos que solvente problemáticas sociales. Por lo expuesto, la Proyección Social se constituye en la función que permite la interacción de las IES con las comunidades y sus líderes comunitarios, esto constituye la motivación del presente trabajo que tiene como objetivo hacer un abordaje teórico y formular una serie de recomendaciones para la formación de líderes comunitarios y la ejecución de proyectos mancomunados para de esta manera lograr las grandes transformaciones en la sociedad.
INFLUENCE OF STAFFING LEVELS ON QUALITY OF EDUCATION IN PUBLIC SECONDARY SCHOOLS IN MURANG’A COUNTY, KENYA
Authors: Mwaniki Wilson , Nyerere Jackline , Ogola Martin 
Published: June 2022

Statement of the Research Problem: Teaching staff is crucial in the provision of quality education in public secondary schools. However, in Murang’a County, many public secondary schools registering a low quality of education.
Purpose of the Study: This study aimed at determining the influence of staffing levels on quality of education in public secondary schools in Murang’a County, Kenya.
Methodology: The study adopted a correlation research design. This study targeted 292 principals and 3206 teachers totaling 3498 from which a sample of 360 respondents (10.3%) was determined using Yamane’s Formula. Using stratified sampling, eight strata considering sub-counties were created. From every sub-county, three principals were selected using purposive sampling. However, from each sub-county, 42 teachers (14 teachers per school) were selected using simple random sampling to avoid bias. Questionnaires were used to gather information from principals and teachers whereas a documentary checklist guide was used by the researcher. Quantitative data were analyzed using descriptive statistics such as frequencies and percentages and inferentially using Pearson’s Product Moment Correlation Analysis with the help of Statistical Packages for Social Sciences (SPSS 23) and presented by using tables.
Research Findings: The study established that students’ academic performance in national examinations (KCSE) is low, students’ completion rates with quality grades (C+ and above) are on a decreasing trend and levels and frequency of participation in co-curricular activities are low. From the study findings, the student-teacher ratio in public secondary schools is high owing to the high number of students enrolled courtesy of the Free Day Secondary Education Policy. This implies that, by having an inadequate number of teachers, it is difficult to attend to academic and other delegated duties and thus, not possible to accord students individual attention, which is the essential aspect of quality education.
Unique Contribution to Theory, Policy and Practice: The findings of this study lend credence to the premise of the Education Production Function Theory since it revealed that there is a correlation between instruction resources and quality of education. As a practice, secondary schools should engage in alternative income-generating activities to acquire more financial resources to hire more teachers to supplement government’s efforts to bridge the gap in the student-teacher ratio. As a policy, the government should ensure adherence to the policy on fair distribution of teachers based on the number of students.
Malpraktis ve Sağlık Profesyonellerinin Sorumlulukları
Authors: ŞAHBAZ Gamze , YÜCESOY Hüsne , AKIN Özlem , ERBİL Nülüfer 
Published: June 2022

Malpraktis, “sağlık hizmeti sunumu sırasında uygun ve etik olmayan davranış, bilgisizlik, ilgisizlik, özensizlik, deneyimsizlik veya yanlış tedavi nedeniyle hastanın zarara uğraması” anlamına gelir ve sağlık hizmeti sunumunun her aşamasında ortaya çıkabilir. Tıbbi uygulama hataları, tıbbi işleme, ihmale ve uygulamaya bağlı olarak tanı, tedavi, koruyucu tedavi ve diğer hatalar ya da medikasyon ve cerrahi hatalar gibi farklı gruplara ayrılarak incelenebilir. Yasal düzenlemelerde geçen mesleki etik kurallar gereğince, sağlık profesyonelleri, ilgili yasalardaki genel tanımlar çerçevesinde cezai ve hukuki açıdan sorumlu hale gelmektedir. Sağlık profesyonelleri tarafından tıbbi hatalar kasti ve taksirli olarak ortaya çıkabilir. Sağlık profesyonellerinin gerekli tıbbi yardımı zamanında yapmaması halinde tıbbi sorumlulukları vardır. Bu durumda hasta ve hasta yakınlarının tazminat talep etme hakları vardır. Sağlık profesyoneli ile diğer vatandaşların bir insanın hayatı kaybına karşı aynı şekilde sorumludur. Sağlık profesyoneli hapis ya da adli para cezası ile yargılanır. Sorumsuzluk anlaşmasının yapılması, hastanın rızasının alınması sorumluluğu ortadan kaldıran durumlardandır. Sağlık profesyonelleri, tıbbi hatalar konusunda bilgili olmalıdır. Hasta güvenliği kültürü değerlendirilmeli ve geliştirilmeli, hasta güvenliği için iş birliği yapılmalı, hasta güvenliği kurumsal bir sorumluluk olarak benimsenmelidir. Sağlık profesyonelleri bağımsız, yarı bağımlı ve bağımlı rollerini yasa ve yönetmeliklere dikkate alarak görevlerini icra etmelidir. Sağlık profesyonelleri sağlık hizmeti verirken aksaklıklara dikkat etmeli ve tıbbi hataların en aza indirilmesi için önlemler almalıdır.
THE CONCEPT OF SCIENCES IN ISLAM
Authors: Rohmatullah Niam 
Published: June 2022

This research discusses about the concept of science in Islamic perspective. The research was motivated by the fact that the concepts and the definitions of science in Islam is still influenced by the concepts of Greek philosophy. It caused that science is derived from the Greek, not Islam. And it is dangerous for Muslim students. Using comparative analysis. The results of this study concluded that the science in the Islamic view is synchronization between ideals and reality. The experts have different opinions in defining science. However, all the definitions and the terms are materialistic, and very secular. Then, we take the notion expressed by the muslim scholars. The purpose of science is actually should be proportional to the objectives of Islamic education. Thus, the orientation of the knowledge-seeker will be hereafter, not merely pursue to the world.
PEMETAAN HASIL ASSESMENT DAN INTERVENSI PROBLEM KELUARGA BERENCANA
Authors: Nur Fajriah Zubaedah , Sa’adah Nurus 
Published: June 2022

Keluarga berencana merupakan salah satu usaha dalam meningkatkan kesejahteraan masyarakat melalui pemberian nasehat perkawinan, pengobatan kemandulan, penjarangan kelahiran hingga yang baru-baru ini adalah pencegahan stunting. Pemerintah mengupayakan kesejahteraan keluarga melalui berbagai program. Tujuan dalam penelitian ini yakni untuk memberikan peta intervensi berbagai permasalahan yang berorientasi keluarga untuk menuju keluarga berencana. Metode dalam penelitian ini yakni menggunakan metode studi literatur yang mengkaji berbagai artikel dalam jurnal nasional. Proses pengkajian artikel dilaksanakan dengan tujuan mencari sesuatu yang dianggap sebagai sebuah kebaruan (novelty). Pengumpulan data menggunakan metode studi pustaka terhadap publikasi jurnal. Hasil dari penelitian ini yakni bahwa program orientasi kehidupan berkeluarga yang sudah ada bersumber dari pemerintah dan masyarakat. Program yang bersumber dari pemerintah yang diterapkan dalam organisasi masyarakat misalnya program Generasi Berencana, PIK-R, INCAR, Duta Genre, BKR, dan berbagai layanan yang diterapkan baik dalam lembaga pemerintahan maupun lembaga sosial. Program yang diimplementasikan di lingkungan sekolah dengan sasaran peserta didik usia remaja seperti kegiatan layanan orientasi, PKBR, Layanan info klasikal serta layanan bimbingan remaja kelompok antar siswa. Kegiatan yang dihasilkan dari kreativitas masyarakat salah satunya yakni majlis ta’lim yang menyisipkan kegiatan bimbingan dan konseling bagi para jamaahnya
Pengaruh Leverage dan Profitabilitas Terhadap Nilai Perusahaan (Studi Empiris 16 Perusahaan Sektor Konsumsi yang Terdaftar di Bursa Efek Indonesia
Authors: Riswanto Aris 
Published: June 2022

The manufacturing industry is showing very promising developments, especially in the aspect of manufacturing value added in the consumer goods sector. Because the products are needed by the wider community. This study aims to analyze how the influence of leverage and profitability on company value, the Food and Beverages Sector Companies listed on the Indonesia Stock Exchange. The research method used is descriptive method and verification method. The sampling technique was carried out using the purposive sampling method, and a sample of 14 Sector Food and Beverages Companies listed on the Indonesia Stock Exchange, in 2015 - 2019. Data analysis used in this study was multiple regression analysis.
Statistical test results show that the leverage variable has a relationship with firm value, with a moderate level, while the profitability variable has a very strong relationship with company value. From the results of the research, solvency and profitability have a significant positive effect on firm value. This means that the higher the leverage and profitability, the higher the value of the company. Leverage variables and profitability variables have a significant positive effect on the value of the company, meaning that together the higher the leverage and profitability the higher the value of the company.
Pengaruh Promosi Online Terhadap Keputusan Pembelian Jasa Transportasi Online Grab di Kota Pagar Alam
Authors: Elvera  , Mico Sastra 
Published: June 2022

Penelitian ini bertujuan untuk mengetahu pengaruh promosi online terhadap keputusan pembelian jasa transportasi online grab di Kota Pagar Alam. Populasi dalam penelitian ini adalah masyarakat Kota Pagar Alam yang berjumlah 75 responden. Penelitian ini menggunakan penelitian asosiatif dengan pendekatan kuantitatif. Teknik pengambilan sampel adalah Simple random sampling yang artinya pengambilan anggota sample dan populasi dilakuakan secara acak tanpa memperhatikan strata yang ada dalam populasi itu. Analisis data menggunakan analisis regresi linear sederhana dan uji t. Hasil dari uji regresi linier sederhana pada penelitian ini menunjukan bahwa promosi online berpengaruh positif dan signifikan terhadap keputusan pembelian jasa transportasi online grab di Kota Pagar Alam sehingga dapat diketahui persamaan regresi linear sederhana yaitu Y = 7.789 + 0,277 X. Dimana nilai konstanta sebesar 7.789 dan nilai koefisien regresi linier promosi online mempunyai pengaruh yang positif. Jika promosi online meningkat sebesar satu satuan maka keputusan pembelian akan meningkat sebesar 0,277 satuan. Hasil dari uji t dimana nilai signifikannya sebesar 0,000 yang berarti lebih kecil dari 0,05 sehingga hipotesis diterima.
Kontekstualisasi Misi Terhadap Budaya Bakar Batu Suku Lani dan Implementasinya bagi Gereja Injili di Indonesia (GIDI) Jemaat Jigunikime Puncak Jaya Papua
Authors: Manafe Debertje Setriani , Morib Tekies , Pelamonia Risart 
Published: June 2022

Bakar Batu merupakan adat istiadat memasak makanan menggunakan batu panas. Bakar Batu berfungsi sebagai tradisi makan bersama, berkumpul, mengungkapkan rasa syukur, saling berbagi, dan damai. Bakar Batu merupakan warisan nenek moyang suku Lani yang dilakukan apabila merasa bingung, takut, lemah dan sakit. Ritual ini dilakukan untuk` mencari petunjuk sehingga mereka terlibat dalam kuasa gelap. Kontekstualisasi misi tehadap budaya Bakar Batu Suku Lani bukanlah Bakar Batu yang bertujuan makan bersama melainkan Bakar Batu yang mengadakan ritual gaib yang bertentangan dengan Alkitab. Rumusan masalahnya adalah Bagaimana implementasi kontekstualisasi misi terhadap budaya Bakar Batu Suku Lani bagi jemaat Jigunikime? Tujuan penelitian untuk menjelaskan bahwa dengan memakai model kontekstualisasi misi yang tepat, maka jemaat Jigunikime dapat memberitakan Injil melalui kontekstualisasi budaya Bakar Batu. Metode yang digunakan adalah metode penelitian studi kasus dan analisis isi dengan pendekatan kualitatif. Respondennya adalah 60 jemaat dari usia 25 tahun ke atas. Dari 60 jemaat yang aktif ke gereja hanya 35 orang, Jadi, sampel yang diambil 35 orang jemaat. Instrumen pengumpulan informasi yang dipakai dalam riset ini adalah angket dan wawancara. Hasil yang didapat dalam riset ini yaitu jemaat Jigunikime dapat memakai 3 model kontekstualisasi misi yakni transformasi: Melalui kebudayaan, Allah berhubungan dengan seseorang saat seseorang diperbaharui Allah, hingga budayanya pula diperbaharui (2 kor 5:17). dan model akomodasi: tindakan menghormati serta keterbukaan kepada budaya asli yang dilakukan di dalam tindakan, sikap, dan pendekatan praktis kontekstualisasi misi. Serta model transendental, menjadi tekanan utamanya adalah pengalaman individu sehingga praktisi kontekstualisasi harus orang dari budaya itu sendiri.
Perbedaan Ekstraksi Daun Teratai (Nymphaea Pubescens Willd) Sebagai Fungsi Aktivitas Antioksidan
Authors: Chandra Boy , Asra Ridho , Mevia Nadya Arta 
Published: June 2022

Teratai (Nymphaea pubescens Willd.) adalah salah satu tumbuhan yang mengandung banyak senyawa kimia yang bermanfaat bagi kesehatan manusia. Daun teratai mengandung senyawa flavonoid, tanin, fenol dan asam galat yang diketahui memiliki aktivitas antioksidan. Tujuan penelitian ini untuk menentukan kandungan senyawa kimia dan aktivitas antioksidan yang terdapat pada daun teratai (Nymphaea pubescens Willd.) berdasarkan perbedaan metode ekstraksi. Metode yang digunakan yaitu metode maserasi dengan pelarut etanol 70% dan rebusan dengan aquadest. Dari hasil ekstraksi yang diperoleh, dilakukan skrining fitokimia dan aktivitas antioksidan dengan metode 1,1-difenil-2- pikrilhidrazil (DPPH). Pada metode maserasi menggunakan etanol terdapat kandungan kimia seperti alkaloid, flavonoid, saponin, tannin dan fenol, sedangkan dari metode rebusan dengan air didapatkan kandungan kimia seperti flavonoid, tanin dan fenol. Pada pengujian aktivitas antioksidan, didapatkan nilai IC50 56,4088 μg/mL (kuat) dan 375,4779 μg/mL (lemah) untuk masing-masing ekstrak etanol dan ekstrak air. Dari penelitian ini dapat disimpulkan bahwa ekstrak etanol mengandung lebih banyak senyawa kimia dan memiliki aktivitas antioksidan yang lebih kuat dibandingkan dengan ekstrak air.
A Priori Justification in Nietzsche
Authors: Remhof Justin 
Published: June 2022

Abstract
This paper argues there are crucial points in Nietzsche's texts where he offers a priori epistemic justification for views he believes are correct, contrasting with the dominant view that Nietzsche's philosophical naturalism is incompatible with a priori justification. My aim is to develop Nietzsche's brand of a priori justification, show that he employs this account of justification in the texts, and suggest how it might be compatible with naturalism.
Differences of Search Engine Digital Footprints Between Podiatrists and Foot and Ankle Orthopaedic Surgeons: A Need to Join the Digital Era
Authors: Chiang Benjamin J. , Malik Zeeshan , Laubach Logan , Minchu Prem , Gu Alex , Chodos Marc D. 
Published: June 2022

Background:
Search engines generate lists of the most relevant websites using a keyword or phrase query and are integral in guiding consumer preferences. Digital information is important in the field of medicine, influencing what patients learn about their conditions and who they choose as providers. When two types of healthcare providers, such as podiatry and foot and ankle orthopaedic surgeons (FAOSs), share an overlapping consumer market, whichever group has a larger digital footprint receives increased digital engagement.

Methods:
The Google search engine was used to query nine common foot and ankle–associated terms using a “search term + zip code” format for 150 zip codes divided into urban, suburban, and rural population densities. The first 10 results of each search were classified into one of five categories. Site content was classified as podiatry-oriented, other MD/DO-oriented, or FAOS-oriented. Separately, a ratio between podiatrists and FAOSs was calculated for each population density group. Data were then normalized using this ratio and reanalyzed with the Wilcoxon signed-rank test with significance at P < 0.05.

Results:
Of 13,500 total search results, 4,992 (36.9%) were podiatry-oriented, 2,109 (15.6%) were other MD/DO-oriented, and 436 (3.2%) were FAOS-oriented. All geographic areas featured a higher number of podiatry than FAOS-oriented sites. FAOSs have more results per provider in urban areas (P < 0.001), although podiatrists had more in suburban and rural areas (P < 0.001, P < 0.001). Podiatrists have greater digital engagement in descriptive search terms. “Ankle replacement” has greater FAOS engagement in all three geographic areas.

Discussion:
Foot and ankle–related Internet search terms results are overwhelmingly composed of podiatry-oriented sites. Per provider, regional differences are demonstrated, with FAOS having more sites in urban areas only. FAOS scope-of-practice terms such as “ankle replacement” still retain greater engagement by FAOSs. Search engine optimization and saturation strategies should be considered.

Level of evidence:
Level 3 (observational study).