bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcome of 177Lu-PSMA Radionuclide Treatment in Advanced Prostate Cancer and Its Association With Clinical Parameters
Authors: Has Simsek Duygu , Kuyumcu Serkan , Karadogan Seyfullah , Ozkan Zeynep Gozde , Isik Emine Goknur , Basaran Mert , Sanli Mehmet Oner , Sanli Yasemin 
Published: May 2022

Purpose
This study was set out to analyze the efficacy and safety of 177Lu-PSMA-617 (LuPSMA) treatment in metastatic castration-resistant prostate cancer (mCRPC) patients.

Patients and Methods
Progressive mCRPC patients who received at least 1 cycle of LuPSMA therapy were evaluated retrospectively. Demographic, clinic, and histopathological data were documented. Treatment efficacy was determined based on biochemical response criteria (Prostate Cancer Clinical Trial Working Group 3), and toxicity rates were defined based on CTCAE v4.03. The prognostic significance of laboratory/clinical data and 68Ga-PSMA PET/CT quantitative results were analyzed using SPSS Version 24.0.

Results
One hundred patients (median prostate-specific antigen [PSA] level, 75.7 ng/mL) who met the eligibility criteria were identified. The median number of cycles received per patient was 3 (range, 1–9). After the first cycles of LuPSMA, biochemical partial response, biochemical stable disease, and biochemical progressive disease were observed in 31%, 36%, and 33% of patients, respectively. Any PSA decline was determined in 60% of patients. After the fourth cycle of treatment, biochemical partial response, biochemical stable disease, and biochemical progressive disease were defined in 48%, 26%, and 26% of patients, respectively. The median overall survival (OS) from the first cycle of LuPSMA was 14 months. Patients who had any PSA response after the first cycle had significantly longer OS than nonresponders (median OS: 17 vs 9 months; P ≤ 0.001). Total PSMA-derived tumor volume (P = 0.004), total PSMA activity per lesion (P = 0.01), PSA (P = 0.007), alkaline phosphatase (P = 0.002), lactate dehydrogenase (P < 0.001), and hemoglobin (P < 0.001) were significant prognostic factors for OS in univariate Cox regression analysis.

Conclusions
LuPSMA therapy is a favorable treatment for mCRPC with remarkable therapeutic efficacy and low toxicity rates, even in progressive disease under standard therapies. Baseline PSMA-based tumor burden, PSA, alkaline phosphatase, lactate dehydrogenase, and hemoglobin were significant predictors of OS and can be useful for selection of the best candidate for LuPSMA therapy.
Coupling of Inflammation and Microcalcification in the Pathogenesis of Prostate Calculi
Authors: Park Peter Sang Uk , Khurana Navpreet , Werner Thomas J. , Høilund-Carlsen Poul F. , Alavi Abass 
Published: May 2022

Abstract
Prostatic calculi are common and usually asymptomatic calcified stones frequently found incidentally in imaging or during the evaluation of benign prostatic hyperplasia. Those associated with chronic prostatitis can lead to bacterial colonization, inflammation, and blockage of secretory ducts, resulting in pelvic pain and lower urinary tract symptoms. Although PET tracers such as 18F-NaF and 18F-FDG have been used to assess metastatic and benign bone disorders, their comparative avidity in the domain of extraosseous and prostate calcification remains to be fully explored. We present incidentally detected bilateral prostatic calcification in an asymptomatic 42-year-old man exhibiting coavidity of 18F-NaF and 18F-FDG, highlighting the molecular coupling of inflammation and microcalcification in the pathogenesis of prostate calculi.
Prostate Cancer With Solitary Bone Metastasis in the Mandible
Authors: Lu Yang 
Published: May 2022

Abstract
A 79-year-old man with prostate cancer found to have a solitary bone lesion in the mandible on initial staging bone scan. The sclerotic lesion had a sunburst appearance on CT. As biopsy was nondiagnostic, the patient underwent segmental mandibulectomy. Postoperative pathology results confirmed as metastasis from prostate cancer.
Simultaneous Detection of 2 Types of Malignancies in a Pediatric Patient on FDG PET/CT Led to Diagnosis of Li-Fraumeni Syndrome
Authors: Kan Ying , Si Yukun , Wang Wei , Yang Jigang 
Published: May 2022

Abstract
A 17-month-old girl underwent FDG PET/CT to evaluate a right adrenal lesion, which showed abnormal 18F-FDG avidity. In addition, an unexpected lesion with mild 18F-FDG uptake was noted in the right anterior thoracic wall. Pathology demonstrated adrenocortical carcinoma in the right adrenal and rhabdosarcoma in both the left forearm and right anterior thoracic wall. Gene analysis confirmed the diagnosis of Li-Fraumeni syndrome. The present case emphasized FDG PET/CT value of showing simultaneously multiple lesions in Li-Fraumeni syndrome, especially in the early stage without the gene analysis result.
Surgeon Attitudes Toward Concurrent Urogynecologic and Gynecologic Oncology Procedures: A Cross-sectional Survey
Authors: Lai Erica , Goldberg Gary L. , Shalom Dara 
Published: May 2022

Importance
There is increasing overlap in the urogynecologic and gynecologic oncologic patient populations. To improve patient advocacy and access to care, a collaborative surgical approach may benefit this cohort.

Objective
The aim of the study was to evaluate surgeon attitudes toward performing concurrent urogynecologic and gynecologic oncology procedures. We hypothesized that most surgeons are amenable to collaboration.

Study Design
We conducted a cross-sectional questionnaire of members of the Society of Gynecologic Oncology and the American Urogynecologic Society from August to November 2020. A 23-item online survey was created to assess surgeon demographics, practice and screening patterns, and attitudes toward surgical collaboration. We also evaluated obstacles to performing joint procedures and assessed whether attitudes could be influenced by new information.

Results
A total of 338 surveys were included in the analysis, including 158 urogynecologists and 226 gynecologic oncologists (GOs). Most surgeons (77.8%) will recommend concurrent procedures with another specialty, and 97.8% of urogynecologists and 95.7% of oncologists currently perform joint surgical procedures. Male surgeons, regardless of specialty, were more likely to recommend staged procedures (44% vs 31%, P < 0.001), as were GOs (28% vs 10.1%, P < 0.001). However, oncologists were more likely than urogynecologists to initiate referrals for surgical collaboration (33.3% vs 14.4%, P < 0.001).

Conclusions
A total of 22.2% of urogynecologists and oncologists prefer staging surgical procedures. The most common barrier to a combined procedure was logistics. Urogynecologists were more concerned about the effects of cancer treatments on healing, the use of mesh implants, and financial reimbursements as compared with GOs. Treatment delay was a significantly greater concern for the oncologists.
Analysis of the operation principle for tubular flux-switching permanent magnet linear machine
Authors: Zhang Guozhen , Nie Rui , Si Jikai , Feng Xiaohui , Wang Changli 
Published: May 2022

Purpose
This study aims to unveil the generation mechanism of the thrust force in a tubular flux-switching permanent magnet (PM) linear (TFSPML) machine; the operation principle of the TFSPML machine is analyzed.

Design/methodology/approach
First, the air-gap flux density harmonic characteristics excited by PMs and armature windings are investigated and summarized based on a simple magnetomotive force (MMF)-permeance model. Then, the air-gap field modulation theory is applied in analyzing the air-gap flux density harmonics that contribute to the electromagnetic force. In addition, a simple method for separating the end force of the TFSPML machine is proposed, which is a significant foundation for the comprehensive analysis of this type of machine. As a result, the operation principle of the TFSPML machine is thoroughly revealed.

Findings
The analysis shows that the average electromagnetic force is mainly contributed by the air-gap dominant harmonics, and the thrust force ripple is mainly caused by the end force.

Originality/value
In this paper, the operation principle of the TFSPML machine is analyzed from the perspective of air-gap field modulation.
Ten years on: a post-occupancy evaluation of classrooms for pupils with severe autism
Authors: Irish Julie E.N. 
Published: May 2022

Purpose
There is currently a lack of research describing the best way to design learning environments for increasing numbers of children with autism. The purpose of this study was to determine the impact of classroom design on the learning and behaviour of pupils with severe autism. The research variables of interest were classroom layout; furniture, fittings and equipment (FFE); materials; colour scheme; wayfinding; lighting; acoustics; and security.

Design/methodology/approach
This study conducted a post-occupancy evaluation of classrooms for pupils with severe autism aged 3–19 in a school ten years after its completion. Data collection included a visual assessment of the building and an online survey to educators and administrators asking how satisfied they were that the research variables benefited pupils with severe autism.

Findings
Key findings were that zoned areas for different activities met students’ needs. Withdrawal rooms off the classroom, access to shared hygiene facilities and a secure outdoor area received high ratings. The main criticisms were the lack of robustness of FFE and the inability to control temperature. Results were collated into a table of recommendations for classroom design for severely autistic pupils.

Originality/value
The findings demonstrate classroom features that support the needs of pupils with severe autism, an area with limited prior research. Some findings support previous research and some adds new knowledge to our understanding of design for this population. The results provide empirical evidence for professionals involved in designing classrooms for pupils with severe autism.
Physicians' experiences of challenges in working conditions related to the provision of care during the initial response to the COVID-19 pandemic in Sweden
Authors: Nilsson Karin , Landstad Bodil J. , Ekberg Kerstin , Nyberg Anna , Sjöström Malin , Hagqvist Emma 
Published: May 2022

PurposeThis aim of this study was to explore how hospital-based physicians in Sweden experienced the challenges in working conditions related to the provision of care during the initial response to the COVID-19 pandemic in 2020 when hospitals transitioned to pandemic care.Design/methodology/approachThe study has a qualitative design. Twenty-five hospital-based physicians were interviewed about their experiences from working in a hospital while healthcare organisations initially responded to COVID-19 pandemic in 2020. A thematic analysis was used to analyse the empirical material.FindingsThe analysis resulted in four themes: involuntary self-management, a self-restrictive bureaucracy, passive occupational safety and health (OSH) management, and information overload. These themes reflect how the physicians perceived their work situation during the pandemic and how they tried to maintain quality care for their patients.Practical implicationsThe study gives valuable insights for formulating preparedness in regard to crisis management plans that can secure the provision of care for future emergencies in the healthcare services.Originality/valueThis paper shows that a crisis management plans in the healthcare services should include decision structures and management, measures of risk assessment and OSH management, and the maintenance of personnel wellbeing. A prepared healthcare management can preserve quality care delivery while under crisis.
Digital marketplace for tourism resilience in the pandemic age: voices from budget hotel customers
Authors: Huda Miftachul 
Published: May 2022

Purpose
This paper aims to examine the initiative of low-price hotels, budget hotels, in Malaysia, to restore the financial sustainability through empowering the digital marketplace strategy in the tourism resilience sector. Giving an open accessibility to customers for achieving their venue with a low price and have a friendly service comes from initiating the digital marketplace arrangement.

Design/methodology/approach
This study focuses on what is the importance of the digital marketplace strategy for tourism resilience in the pandemic age and how is it important. The data come from qualitative interview from one couple, husband and wife, regarding the budget hotel operation practice in the city of Sri Iskandar, the Perak state of Malaysia.

Findings
The findings revealed the importance of initiating the strategy of digital marketplace in enabling the customers’ personalised decision towards the tourism destination they prefer based on their needs of low-cost and proper service. There are three main points, namely the importance of digital marketplace for tourism market enhancement, readiness of digital marketplace for tourism market enhancement and continued capacity to strategize digital marketplace for tourism market enhancement. The initiative to commit with applying for the resilience for tourism sustainability in the pandemic age is important to ensure they can take a small advantage continually with the frequent customers’ sustainability.

Originality/value
This paper is supposed to contribute in developing the resilience practice through advancing the strategy of digital marketplace in raising the tourism sector, budget hotel operators. The main occupation aims to empower resilience for tourism sustainability in the pandemic age, in order to recover the market in online platform.
Covid-related educational policies in action: a system dynamics view
Authors: Costanza Francesca 
Published: May 2022

PurposeThe purpose of this paper is to adopt a learning-based approach to portray the impact of Covid-19 on state school services in Italy, with a specific focus on the role of street-level bureaucrats and the triggering of co-creative processes.Design/methodology/approachThe study proposes a qualitative system dynamics (or SD) approach describing the implementation of Covid-related educational policies in Italy. An insight model, made of causal loop diagrams, integrates the selected multi-disciplinary literature and institutional sources, secondary data from national and local reports (about Palermo, the fifth largest metropolitan city in Italy) and insights from a panel of school street–level bureaucrats.FindingsThe study provides an insight into the impacts of governmental decisions (school closures and the subsequent need to activate distance learning during the first wave of Covid-19) at a local level. Specifically, it portrays the influences of managerial and professional discretion, infrastructural equipment and socio-economic factors favouring/deterring co-creative educational processes.Practical implicationsThe SD model highlights vicious/virtuous circles in policy implementation and suggests new managerial paths for education, more routed towards public value creation and less attached to bureaucratic procedures and the unquestioning application of performance culture.Originality/valueThe paper proposes an original and holistic approach to dealing with policy making in education and its managerial features. The research findings are considered important, not only to face the current emergency, but also to pro-actively think about the post-Covid era.
The super engagers of freemium gamified services: using multimethod approach to examine why highly interactive consumers become paying consumers
Authors: Gupta Keshav , Su Yiran , Kunkel Thilo , Funk Daniel 
Published: May 2022

PurposeOnline services are increasingly utilizing gamification techniques to encourage consumer loyalty and engagement. However, the majority of the gamified services fail to be financially sustainable. Existing freemium and gamified services literature provides scant knowledge on behavioral predictors of in-app purchases in freemium gamified services. The research examines highly interactive consumers' in-app behaviors using competition-based motivational affordances, daily usage behavior and social competition motivation that convert them into super engagers.Design/methodology/approachThe authors applied a multimethod approach by using Multivariate Logistic Regression (n = 685) to analyze in-app behavioral data and Qualitative Comparative Analysis (n = 94) to examine survey and in-app behavioral data of highly interactive consumers of a freemium gamified service to explain paying behaviors.FindingsResults reveal highly interactive consumers that elicit heavy daily usage of the application or excel at in-app challenges are less likely to convert to super engagers. Among super engagers, some are socially competitive, and their inability to advance in the leaderboard corresponds to in-app purchases, while non-socially competitive consumers make purchases to collect extrinsic rewards. Additionally, highly interactive consumers who possess more knowledge about the gamified service become super engagers to increase their chances to be socially competitive.Originality/valueThis research examines in-app behaviors of highly interactive consumers of a freemium gamified service that lead to in-app purchases following varying levels of daily usage behavior and social competition motivation. The authors contribute to the previous literature by defining and examining a new consumer segment – super engagers – that is financially beneficial for freemium services because of their in-app purchases. The authors provide insight on in-app behaviors that convert highly interactive consumers to super engagers and demonstrate that the reason for highly interactive consumers to make in-app purchases is a function of acquiring specific internal and external rewards based on their level of social competition.
I cannot be creative due to my exploitative leader! A moderated mediation interplay of leader–member exchange quality and knowledge hiding
Authors: Feng Yanchao , Ayub Arslan , Fatima Tehreem , Irfan Saira , Sarmad Muhammad 
Published: May 2022

PurposeWith an emphasis on displaced aggression theory and social exchange theory, this study aims to investigate the harmful effects of exploitative leadership (EL) on employee creativity (EC) through the mediating role of knowledge hiding (KH). Moreover, this study examines the boundary effects of leader–member exchange (LMX) to explore conditions under which KH is more or less likely to occur.Design/methodology/approachThe study employed time-lagged (i.e. three-wave), multisource (i.e. self-rated and peer-rated) research design to collect data from employees working in Pakistani service sector organizations. The study analyzed 323 responses using SMART PLS (v 3.3.3) to assess the measurement model and the structural model.FindingsThe findings reveal that EL is positively related to KH and negatively related to EC. The results also show partial mediating role of KH in the indirect relationship between EL and EC. Besides, the study also found that LMX moderates the positive relationship between EL and KH, and the negative relationship between EL and EC.Practical implicationsThe study divulges interesting findings that subordinates at high-quality LMX relationships (i.e. in-group members) are more susceptible to the harmful effects of supervisory unjust treatment than at low-quality LMX relationships (i.e. out-group members). Thus, occurrence context of KH, i.e. EL should be minimized through appropriate organizational interventions.Originality/valueThis study contributes to the leadership and knowledge management literature by testing a hitherto unexplored moderated mediation model.
Leading in a time of crisis: exploring early experiences of health facility leaders during the COVID-19 pandemic in Nigeria’s epicentre
Authors: Balogun Mobolanle , Dada Festus Opeyemi , Oladimeji Adetola , Gwacham-Anisiobi Uchenna , Sekoni Adekemi , Banke-Thomas Aduragbemi 
Published: May 2022

Purpose
The COVID-19 pandemic has had a disruptive effect on the health system. Health facility leaders were at the forefront of maintaining service delivery and were exposed to varied stressors in the early phase of the pandemic. This study aims to explore the leadership experiences of health facility leaders during the early phase of the COVID-19 pandemic in Nigeria’s epicentre.

Design/methodology/approach
This study conducted an exploratory descriptive qualitative study. To achieve this, 33 health facility leaders of different cadres across primary, secondary, and tertiary levels of the public health care system in Lagos, Nigeria, were remotely interviewed. The key informant interviews were transcribed verbatim and were analysed by using thematic analysis.

Findings
The health facility leaders experienced heightened levels of fear, anxiety and stressors during the early phase of the pandemic. They also had genuine concerns about exposing their family members to the virus and had to manage some health-care workers who were afraid for their lives and reluctant. Coping mechanisms included psychological and social support, innovative hygiene measures at health facility and at home, training and staff welfare in more ways than usual. They were motivated to continue rendering services during the crisis because of their passion, their calling, the Hippocratic oath and support from the State government.

Originality/value
The experiences of health facility leaders from different parts of the world have been documented. However, to the best of the authors’ knowledge, this is one of the first studies that specifically report multi-layer leadership experiences of health facility leaders during the early phase of the COVID-19 pandemic in sub-Saharan Africa.
“To our health!” Perceived benefits offset privacy concerns in using national contact-tracing apps
Authors: Nguyen Tin Trung , Tran Hoang Minh Tu , Phung Minh Tuan 
Published: May 2022

PurposeCommunity health is placed under the limelight during the COVID-19 crisis, providing a unique context for investigating citizens' health-privacy tradeoff in accepting social surveillance technology. To elucidate this tradeoff dilemma, an extended privacy calculus framework integrated with the Health Belief Model, legislative protection, and individual collectivism was examined using the case of national contact-tracing apps.Design/methodology/approachThe hypotheses were tested through PLS-SEM analysis with data collected from a survey on Bluezone – a national app in Vietnam.FindingsThe results indicated the negative impact of privacy concerns, which was offset by the positive effect of perceived benefits in using contact-tracing apps. The effect size of perceived benefits on usage frequency was twice as large as that of privacy concerns. Individual collectivism was revealed as a mitigator of the tradeoff dilemma, as it was positively associated with perceived benefits, whereas legislative protection had no such role. Citizens may perceive legislation protection as invalid when the technologies are developed, implemented, and monitored by the authorities.Originality/valueThe theoretical contributions lie in the extension of the privacy calculus model as well as its application in the context of mobile health apps and surveillance technology. The study empirically corroborated that the privacy calculus theory holds when technologies move along the pervasiveness spectrum. This study also provided actionable insights for policymakers and developers who advocate the mass acceptance of national contact-tracing apps.