bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health, Mental Health, and Time Use: A Canadian Study
Authors: Latif Ehsan 
Published: August 2022

Abstract
Using data from Canadian General Social Survey (Time Use- 2015), the study examined how physical health and mental health are related to individuals' time use in sleep, personal care, non-market work, market work, and leisure. The study used Seemingly Unrelated Regression (SUR) and Tobit methods to estimate models. The study found that physical and mental health are negatively correlated with market hours and positively correlated with sleep and leisure. These results are consistent for both the male sample and the female sample. The study also focused on prime-age individuals and found that physical health and mental health significantly reduced time spent on work and significantly increased leisure time for both males and females.
Effect of heterologous platelet-rich plasma (PRP) on liver and modulation of glucose metabolism and Wnt signaling pathways in diabetic mice
Authors: Arif Amin , Farooq Adil , Abbasi Muddasir Hassan , Khawar Muhammad Babar , Akhter Tasleem , Ali Humaira Allay , Anjum Mehreen , Mahmood Rabia , Saleem Tayyaba , Sheikh Nadeem 
Published: August 2022

Abstract
Platelet-rich plasma (PRP) is proven a cost-effective therapeutic choice for different ailments. The current study was designed to highlight the effects of heterologous platelet-rich plasma (PRP) on deteriorated hepatic tissues and impaired glucose metabolism in alloxan-induced diabetic mice. A total of thirty (30) male mice were selected and grouped as control (CG), PRP group (PG), diabetic group (DG), treated group 1 (T1G), and treated group 2 (T2G). PG was given a subcutaneous dose of PRP (0.5 ml/kg body weight) twice a week for four weeks. DG, T1G, and T2G were first given a single dose of alloxan intraperitoneally (150 mg/kg) to induce diabetes. PRP (0.5 ml/kg body weight) was given twice a week to T1G and T2G for two and four weeks respectively. After four weeks, all the mice were sacrificed to excise liver for histological observations and gene expression analysis. Hepatic histo-morphological analysis revealed ballooning of hepatocytes, dilatation of sinusoids, and collagen deposition in the alloxan-induced diabetic group (DG) and it was significantly reduced in both T1G and T2G. Additionally, a significant change in the expression of several hepatic genes was observed. Fbp1, G6pc, and Pklr showed an upregulation while a downregulation was detected in the expression of Pck1 in DG. A significant restoration was observed in Fbp1, and G6pc after PRP treatment but no change was observed in Pklr expression. Genes of glycolytic pathway, Hk1 and Gck, were downregulated significantly in DG compared to CG and PRP treatment restore the expression in both treated groups T1G and T2G. Moreover, Wnt2, Wnt4, and Wnt9a genes of the Wnt signaling pathway were also upregulated in DG, conversely, downregulate in T1G and T2G. No significant change in expression of Wnt5b and Wnt9b was observed in DG compared to control. Current study revealed that PRP anticipates a reduction in glucose production and glucose consumption by ameliorating hepatic tissue and modulating the glucose metabolism. So, it may use as one of the adjunctive therapies to treat T2DM in future but further more detailed investigations are suggested.
The Wandering Spleen: Laparoscopic Splenectomy in a Pregnant Woman. Case Report and Review of the Literature
Authors: Crepaz Lorenzo , Leo Alberto Di , Borzellino Giuseppe , Pomini Paola , Genna Michele 
Published: August 2022

Abstract
Introduction: Wandering spleen (WS) is a rare condition, which is characterized by an augmented mobility of the spleen, due to congenital or acquired causes. It’s more frequent in multiparous women, but only a few cases are reported during pregnancy. WS is usually asymptomatic until the onset of ìts possible complications, and this can mislead clinicians in reaching the correct diagnosis.Case Report: We report the case of WS with acute splenic infarction in a pregnant woman and its mininvasive surgical treatment, focusing on the clinical and radiological findings that could mislead or drive clinicians to the right diagnosis, or to a potential disaster.Conclusion: Splenic preservation in WS where it’s safe and possible and is the main goal of the treatment. Clinical and radiological findings are the most relevant elements to drive surgical treatment.WS is an insidious condition, and must be included in differential diagnosis in determined cases, to reach the best and opportune treatment for the patient.
Comprehensive analysis of the expression and prognostic value for SNRP members in hepatocellular carcinoma
Authors: Guo Ziwei , Liang Jun 
Published: August 2022

Abstract
Background
Heterogeneity and epigenetic modifications lead to differences among treatment strategies, management and prognosis in hepatocellular carcinomas. The family of small nuclear ribonucleoprotein polypeptides (SNRPs) plays a crucial role in tumorigenesis and progression. However, the expression profile and prognostic impact of these family members are not clear. Here, we discuss the expression levels and prognosis of SNRPs. family members
Methods
We compared the transcript levels of each SNRPs member in pan-cancerous tissues by ONCOMINE and further analyzed the expression levels and tumor staging of these markers in hepatocellular carcinoma using UALCAN and GEPIA online databases, while assessing the prognostic value of their mRNA expression and performing functional enrichment analysis by Metascape software using Kaplan–Meier plotter database.
Results
These results showed that mRNA levels of each member of SNRP (B, D1, D2, D3, E, F, G) were significantly upregulated in hepatocellular carcinoma compared to normal tissue and were more highly expressed in patients with advanced hepatocellular carcinoma. mRNA expression of SNRPB, SNRPD1 and SNRPG was associated with poorer overall survival (OS), recurrence-free survival (RFS) and progression-free survival (PFS), which was considered to be statistically significant.
Conclusion
We systematically analyzed the mRNA expression and prognostic significance of each member of SNRPs in HCC and demonstrated the correlation, interaction network, gene alteration and functional enrichment among SNRPs members. Our data suggest that SNRPs members as oncogenes may be a potential indicator of HCC.
Ultra-high-resolution CT features of pulmonary nodules correlate with visceral pleural invasion in early stage lung adenocarcinoma
Authors: Li Lu , Li Huimin , Chen Xiaorong , Pan Jiangfeng , Wang Lixia , Shu Jiner , wu xiaoming 
Published: August 2022

Abstract
Background
visceral pleural invasion (VPI) is an important prognostic factor in early stage lung adenocarcinoma, which can affect the TNM Classification of Tumors.To investigate whether ultra-high-resolution computed tomography (U-HRCT) features can predict VPI of early stage pulmonary nodules contacting the interlobar pleura.
Methods
A total of 126 patients with lung adenocarcinoma (age, 24–77 years) confirmed by surgical pathology were retrospectively enrolled. All patients underwent U-HRCT scan and were divided into two groups according to pulmonary nodular type: pure (pGGN) and mixed (mGGN). Clinical features were recorded, and U-HRCT features were manually measured using PHILIPS EBW V4.5.5. Univariate and multivariate logistic regression were used to determine factors that can significantly predict VPI.
Results
U-HRCT and three-dimensional orthogonal post-processing method could better display the relationship between GGNs and interlobar fissures. Among all patients, fifteen patients (12%) had VPI. None of the patients with pGGN had VPI. In the mGGN group, the solid ratio (odds ratio [OR] = 1.275, 95% CI 1.1-1.478; P = 0.001) and solid diameter (OR = 1.139, 95% CI 1.06–2.346; P = 0.046) were independent risk factors for VPI in early stage lung adenocarcinoma. For VPI diagnosis, the area under the curve, sensitivity, and specificity of the solid ratio and solid diameter were 0.803, 80%, and 75% and 0.807, 80%, and 80.36%, respectively.
Conclusion
U-HRCT can display GGNs and interlobar fissures in detail. VPI was not detected in patients with pGGN. In patients with mGGNs, a solid diameter > 6mm and solid ratio > 38% can be independent predictors of VPI, which may be helpful in surgical decision-making.
Analysis of GPON capacity by hybrid splitting-ratio base on customer segmentation for Indonesian market during the Covid-19 pandemic
Authors: Hantoro Gunadi Dwi , Priambodo Purnomo S. , Wibisono Gunawan 
Published: August 2022

During the Covid-19 pandemic, the impact on internet demand is very high throughout the world. In Indonesia, through a survey conducted, broadband users recorded 175 million people or equivalent to 64 % of the population. Based on field observations, the Passive Optical Network (PON) port utility in the Optical Line Terminal (OLT) is presently below 75 %, as opposed to the initial value, which was more than 95 % [1]. Furthermore, it was also found that more than 80 % of IndiHome customers use a maximum bandwidth of 20 Mbps with majority using 10 Mbps, which is very ineffective, especially related to network capacity. Generally, passive Optical Distribution Network (ODN) devices are not optimally used, therefore this research aims to determine the optimization level of the FTTH network by maximizing the available infrastructure capacity. This process was carried out by increasing the associate ratio of 1:32 to 1:64 while taking into account the Optical Line Terminal (OLT) capacity factor and the standard link budget with schemas A, B and C used to obtain adequate efficiency. Scheme A consists of a 1:2 passive splitter in the Optical Distribution Cabinet (ODC) & 1:32 at the Optical Distribution Point (ODP). Scheme B consists of a 1:4 (ODC) & 1:16 (ODP) passive splitter, while scheme C consists of a 1:8 (ODC) & 1:8 (ODP) passive splitter intended for the use of different customer area types. The result showed an increase in network capacity from 32 to 64 per PON port while taking into account the technical quality of the Link Budget. In conclusion, to ensure this solution functions properly, both simulation and direct measurement tests are carried out using the existing network
GOOGLE TRENDS “ALTIN” ARAMALARI İLE ALTIN FİYATLARI ARASINDAKİ İLİŞKİNİN ANALİZİ
Authors: YÜRÜK Muhammed Fatih , KAYA Zekayi 
Published: July 2022

With the rapid development of information technologies, the coverage area of the internet network is also growing. The development of information technologies has brought with it the concept of "big data". Those who use this data will have an advantage over their competitors. Use of big data; From science to industry, from the private sector to the public, it is now important in many fields. In this study, the causality connection of the course of gold prices was examined by using the data obtained from Google Trends, which presents the search frequency of the keyword searched in the Google search engine. The data set includes monthly data between 01.01.2004-01.12.2021. The scope of the study is on the search frequency of the "gold" keyword in the Google search engine within the borders of Turkey. In the study, the stationarity of the data was analyzed, and then the Johansen cointegration test was used to determine the long-term balance between the variables. The last step was Granger Causality Analysis. As a result of the study, one-way Granger causality towards gold prospecting was determined.
Keywords: Google, Google Trends, Big Data, Granger
Optical property of dissolved organic matter and its correlation with heavy metals in surface water around metal mines to be exploited in southern Anhui Province, China
Authors: Yu Hao , Feng Songbao 
Published: August 2022

Abstract
In this study, we aimed to clarify the optical characteristics of dissolved organic matter (DOM) in the surface water around the metal mine to be exploited and its relationship with heavy metals. In total 11 pond water samples and 21 river water samples were collected around the typical to be exploited metal mine in southern Anhui Province, China. The optical properties of DOM in surface water were studied using ultraviolet-visible (UV-Vis) spectroscopy and excitation-emission matrix (EEM) spectroscopy. Co-occurrence network analysis revealed the intrinsic relationship among UV-Vis spectral parameters, fluorescent components, and heavy metals. The results showed that the DOM in the river had higher content, but its molecular weight was smaller than in the pond. EEM coupled with parallel factor analysis (EEM-PARAFAC) revealed humic-like components (C1 and C2) and protein-like components (C3), and the average content of each fluorescent component in the river was higher than that in the pond. However, except for As, the average content of other heavy metals (Cr, Cu, Cd, Pb, and Zn) in ponds was more significant than in rivers. The co-occurrence network analysis result revealed that there might be different relationships between heavy metals and the DOM due to the various land use.
A Systematic Review and Meta-Analysis on the Effect of Flavonoids
on Insulin-like Growth Factor and Insulin-like Growth Factor
Binding Protein and Incidence of Breast Cancer
Authors: Nasr Shiva , Nakisa Athar , Jandaghian Setareh , Kouhi Monireh , Sadeghi Erfan , Varshosaz Jaleh 
Published: August 2022

Background:
Insulin-like growth factor (IGF-1) is associated with breast cancer
in menopausal women. Naturally occurring biomolecules found in common dietary
protocols, such as flavonoids, play a key role in the inhibition and treatment of cancer.
In-vitro/in-vivo studies showed that treatment involving flavonoids led to a reduced risk
of breast cancer due to the decrease of IGF-1 level in addition to an increased insulin-like
growth factor binding protein (IGFBP)-3. However, clinical studies did not show conclusive
results in this regard because they are contradictory.

Objective:
The aim of the present study was to find the effect of flavonoids on IGF-1 and
IGFBP-3 and the incidence of breast cancer.

Methods:
This systematic review was performed using PubMed, Scopus, ISI Web of Science,
and EMBASE databases to collect results about the clinical use of flavonoids and
their effects on breast cancer. After eliminating duplicate articles, the title and abstract of
the remaining articles were examined in thematic communication, and related clinical articles
were selected and studied based on inclusion criteria. The data were extracted from
each article, and then statistical analysis was subsequently carried out by Comprehensive
Meta-Analysis.

Results:
The results showed that the effect of flavonoids on changes in IGF1 and
IGFBP-3 was not statistically significant. No significant heterogeneity was detected
across the studies. Pooled effect size also indicated that the mean change was not statistically
significant. No significant heterogeneity was detected across the studies. There was
no evidence of publication bias for IGF1 and IGFBP-3.

Conclusion:
This meta-analysis study suggests that flavonoid supplementations have no
significant effect on IGF-1 and IGFBP-3, and a high soy diet has beneficial effects on
IGF system components, which might be useful in breast cancer.
Lyophilization of Molecular Biology Reactions: A Review
Authors: Aoki Mateus Nóbrega , Prado Nayra Oliveira , Lalli Larissa Araújo , Blanes Lucas , Zanette Dalila Lucíola 
Published: August 2022

Abstract:
Molecular biology is a widely used and widespread technique in research and as a laboratory
diagnostic tool, aiming to investigate targets of interest from the obtainment, identification,
and analysis of genetic material. In this context, methods, such as Polymerase Chain Reaction
(PCR), Reverse Transcription Polymerase Chain Reaction (RT-PCR), real-time PCR, loopmediated
isothermal amplification (LAMP), and loop-mediated isothermal amplification with reverse
transcription (RT-LAMP), can be cited. Such methods use enzymes, buffers, and thermosensitive
reagents, which require specific storage conditions. In an attempt to solve this problem,
the lyophilization procedure (dehydration process by sublimation) can be applied, aiming to preserve
and prolong the useful life of the reaction components in cases of temperature variation. In
this review, we present a synthesis of the lyophilization process, describing the events of each step
of the procedure and providing general information about the technique. Moreover, we selected
lyophilization protocols found in the literature, paying attention to the conditions chosen by the
authors for each step of the procedure, and structured the main data in tables, facilitating access to
information for researchers who need material to produce new functional protocols.
Modified Risk Tobacco Products and Cardiovascular Repair: Still Very
“Smoky”
Authors: Cozzolino Claudia , Picchio Vittorio , Floris Erica , Pagano Francesca , Saade Wael , Peruzzi Mariangela , Frati Giacomo , Chimenti Isotta 
Published: August 2022

Abstract:
Smoking habits represent a cardiovascular risk factor with a tremendous impact on health.
Other than damaging differentiated and functional cells of the cardiovascular system, they also negatively
affect reparative mechanisms, such as those involved in cardiac fibrosis and in endothelial progenitor cell
(EPC) activation. In recent years, alternative smoking devices, dubbed modified tobacco risk products
(MRPs), have been introduced, but their precise impact on human health is still under evaluation. Also,
they have not been characterized yet about the possible negative effects on cardiovascular reparative and
regenerative cells, such as EPCs or pluripotent stem cells. In this perspective, we critically review the still
scarce available data on the effects of MRPs on molecular and cellular mechanisms of cardiovascular
repair and regeneration.
Adiciones al listado de plantas ornamentales urbanas de Tunja (Boyacá-Colombia)
Authors: Díaz Pita Mónica Patricia , Álvaro Alba Wilson Ricardo , Porras Flórez Daniela , Lagos López Mayer Isnardo 
Published: August 2022

Se adicionan 89 nuevos registros de especies al listado de plantas ornamentales urbanas de Tunja (Boyacá). Esta contribución se presenta a manera de catálogo con tres grupos taxonómicos, Pteridophyta (2 familias, 2 géneros y 2 especies), Eudicotiledónea (21 familias con 47 géneros, 72 especies y 1 cultivar) y Monocotiledónea (7 familias, 12 géneros y 15 especies). Dentro de las familias, la más importantes a nivel de riqueza fueron Cactaceae (con 13 géneros y 21 especies) y Crassulaceae (con 8 géneros y 21 especies); por consiguiente, el hábito de crecimiento que predominó fueron las suculentas. Se proporciona información como nombre común y origen de cada especie y adicionalmente se incluyen fotografías.
Utilizing Real-time Technology to Assess the Impact of Home Environmental Exposures on Asthma Symptoms: Protocol for an Observational Pilot Study
Authors: Nyenhuis Sharmilee , Cramer Emily , Grande Matthew , Huntington-Moskos Luz , Krueger Kathryn , Bimbi Olivia , Polivka Barbara , Eldeirawi Kamal 
Published: August 2022

Background
It is estimated that over 60% of adults with asthma have uncontrolled symptoms, representing a substantial health and economic impact. The effects of the home environment and exposure to volatile organic compounds (VOCs) and fine particulate matter (PM2.5) on adults with asthma remain unknown. In addition, methods currently used to assess the home environment do not capture real-time data on potentially modifiable environmental exposures or their effect on asthma symptoms.

Objective
The aims of this study are to (1) determine the feasibility and usability of ecological momentary assessment (EMA) to assess self-report residential environmental exposures and asthma symptoms, home monitoring of objective environmental exposures (total VOCs and PM2.5), and lung function in terms of forced expiratory volume in 1 second (FEV1%); (2) assess the frequency and level of residential environmental exposures (eg, disinfectants/cleaners, secondhand smoke) via self-reported data and home monitoring objective measures; (3) assess the level of asthma control as indicated by self-reported asthma symptoms and lung function; and (4) explore associations of self-reported and objective measures of residential environmental exposures with self-reported and objective measures of asthma control.

Methods
We will recruit 50 adults with asthma who have completed our online Global COVID-19 Asthma Study, indicated willingness to be contacted for future studies, reported high use of disinfectant/cleaning products, and have asthma that is not well controlled. Participants will receive an indoor air quality monitor and a home spirometer to measure VOCs, PM2.5, and FEV1%, respectively. EMA data will be collected using a personal smartphone and EMA software platform. Participants will be sent scheduled and random EMA notifications to assess asthma symptoms, environmental exposures, lung function, and mitigation strategies. After the 14-day data collection period, participants will respond to survey items related to acceptability, appropriateness, and feasibility.

Results
This study was funded in March 2021. We pilot tested our procedures and began recruitment in April 2022. The anticipated completion of the study is 2023.

Conclusions
Findings from this feasibility study will support a powered study to address the impact of home environmental exposures on asthma symptoms and develop tailored, home-based asthma interventions that are responsive to the changing home environment and home routines.

Trial Registration
ClinicalTrials.gov NCT05224076; https://clinicaltrials.gov/ct2/show/NCT05224076

International Registered Report Identifier (IRRID)
DERR1-10.2196/39887
Harmonisasi Antar Etnis dan Implikasinya terhadap Ketahanan Wilayah di Kalimantan Barat Pada Era Society 5.0
Authors: Nuryadi Muhammad Hendri , Widiatmaka Pipit 
Published: August 2022

ABSTRACT This study aimed to found out the challenges of ethnic diversity in West Kalimantan in the era of society 5.0; found out strategies for implementing tolerance values in the era of society 5 in West Kalimantan; and found out the implications of regional resilience in West Kalimantan.This study used a qualitative approach and used a descriptive method. The data collection techniques used were in-depth interviews and random sampling techniques, and) literature review (journal articles, proceedings articles, online news accessed on the internet, magazines and books). The data analysis technique in this study had several stages, namely collecting data, condensing data, presenting data, and conclusion.The results of the study showed that the era of society 5.0 was a challenge for ethnic diversity in West Kalimantan, due to the rapid flow of information (hoax) that developed on social media. The response was to implemented the values of tolerance in the life of the nation and state (both in the real and virtual worlds). People in West Kalimantan must be able to realized that it was very important to established a harmonious life for the sake of unity and integrity. The attitudes that must be applied were working together and not looking at differences, realizing that everyone had the same rights, respecting and respecting each other, and accepting other people's opinions, even though they had different opinions. This had implications for strong regional resilience in West Kalimantan, because it affected the existence of ideology, political stability, economic growth, harmonious socio-cultural life, good defense and security.