bluuebunny/crossref_metadata_2025_split huggingface dataset:
N‐Allyl‐N‐ferrocenylmethylamines andansa‐Ferrocenylmethylamines: Synthesis, Structure, and Biological Evaluation
Authors: Mazur Maria , Ziemkiewicz Kamil , Rawiak Karol , Kisiel Kacper , Wińska Patrycja , Deresz Krystyna , Jarzembska Katarzyna N. , Buchowicz Włodzimierz 
Published: January 2022

AbstractReductive aminations of ferrocenecarboxaldehyde,ansa‐ferrocenecarboxaldehyde, and 1,1′‐ferrocene‐dicarboxaldehyde with allylamine,N‐allylmethylamine, orN‐allylaniline were investigated. In the case of the dialdehyde only one formyl group effectively reacted withN‐allylmethylamine orN‐allylaniline, thus providing a simple route to aminomethyl aldehydes and aminomethyl alcohol. 2‐Aza‐ansa[3] ferrocene was also obtained by reacting the dialdehyde with one equivalent of allylamine and subsequent deprotection of the nitrogen atom. The isolatedN‐allyl ferrocene derivatives were completely characterized by spectroscopic techniques, whereas crystal structures of four representative compounds were determined using single‐crystal X‐ray diffraction. MTT assays showed that these simpleN‐allyl ferrocene derivatives display anticancer activity (MCF‐7, A‐549 and PC‐3 cell lines) in the micromolar range.
Investigations into Supramolecular Lyotropic Liquid Crystals Based on 1,3,5‐Benzenetricarboxaramides by NMR Spectroscopy
Authors: Knoll Kevin , Kostner Tobias , Lorenz Christian , Thiele Christina M. 
Published: January 2022

AbstractNew supramolecular lyotropic liquid crystals (LLC) based on 1,3,5‐benzenetricarboxamides (BTAs) with n‐alkylaniline sidechains are described. Using NMR spectroscopy, we investigate the effects of different chain lengths along the homologous series and of non‐BTA additives on liquid crystalline behaviour. From this, we attempt to answer two questions: First, how aliphatic chain length and the addition of further aromatic rings affect the self‐assembly process in general and compared to previously reported systems with purely aliphatic sidechains. Second, whether these modifications are suitable to increases the resulting LLC phases’ resilience against disrupting effects of further, non‐BTA additives.
Fetch and distance from the bay control accretion and erosion patterns in Terrebonne marshes (Louisiana, USA)
Authors: Cortese Luca , Fagherazzi Sergio 
Published: January 2022

AbstractWetlands in the Mississippi River Delta are rapidly degrading. Sea level rise and low sediment supply are widely recognized as the two main factors contributing to land‐to‐water conversion. To determine what marsh areas are more resilient, it is fundamental to identify the drivers that regulate marsh accretion and degradation. In this study, a combination of field data and aerial images is used to determine these drivers in Terrebonne Bay, Louisiana, USA. We find that accretion and degradation patterns depend on whether the marsh is located inland in a sheltered area or facing open water. In the first case, the distance to the nearby channel is important, because during flooding of the marsh platform more sediment is deposited in the proximity of channel banks. The accretion rates of marshes facing open water are high and correlate to fetch, a proxy for the ability of waves to resuspend bottom sediment. These areas are more resilient to sea level rise, but waves are also the main mechanism of degradation, as these marshes tend to degrade by edge erosion. Consequently, we propose a bimodal evolution trajectory of the marshes in Terrebonne Bay: marshes close to the bay and facing open water accrete rapidly but are affected by lateral erosion due to waves, whereas sheltered marshes accrete slowly and degrade in large swathes due to insufficient sediment supply.
ERG amplification is a secondary recurrent driver event in myeloid malignancy with complex karyotype and TP53 mutations
Authors: Lee Winston Y. , Gutierrez‐Lanz Efrain A. , Xiao Hong , McClintock David , Chan May P. , Bixby Dale L. , Shao Lina 
Published: January 2022

AbstractERG is a transcription factor encoded on chromosome 21q22.2 with important roles in hematopoiesis and oncogenesis of prostate cancer. ERG amplification has been identified as one of the most common recurrent events in acute myeloid leukemia with complex karyotype (AML‐CK). In this study, we uncover three different modes of ERG amplification in AML‐CK. Importantly, we present evidence to show that ERG amplification is distinct from intrachromosomal amplification of chromosome 21 (iAMP21), a hallmark segmental amplification frequently encompassing RUNX1 and ERG in a subset of high‐risk B‐lymphoblastic leukemia. We also characterize the association with TP53 aberrations and other chromosomal aberrations, including chromothripsis. Lastly, we show that ERG amplification can initially emerge as subclonal events in low‐grade myeloid neoplasms. These findings demonstrate that ERG amplification is a recurrent secondary driver event in AML and raise the tantalizing possibility of ERG as a therapeutic target.
Risk factors associated with patient‐reported fatigue among long‐term oropharyngeal carcinoma survivors
Authors: Aggarwal Puja , Hutcheson Katherine A. , Goepfert Ryan P. , Garden Adam S. , Garg Naveen , Mott Frank E. , Fuller Clifton D. , Lai Stephen Y. , Gunn Gary Brandon , Chambers Mark S. , Hanna Ehab Y. , Sturgis Erich M. , Shete Sanjay 
Published: January 2022

AbstractBackgroundThe study objective is to identify risk factors associated with fatigue among long‐term OPC survivors.MethodsThis cross‐sectional study included disease‐free OPC survivors treated curatively between 2000 and 2013 who were surveyed from September 2015 to July 2016. The outcome variable was patient‐reported fatigue. Multivariable logistic regression was used to identify factors associated with moderate to severe fatigue.ResultsAmong 863 OPC survivors, 17.4% reported moderate to severe fatigue. Self‐reported thyroid problems (OR: 2.01;p = 0.003), current cigarette smoking at time of survey (OR: 3.85;p = 0.001), late lower cranial neuropathy (OR: 3.44;p = 0.002), and female sex (OR: 1.91;p = 0.010) were concurrent risk factors of reporting moderate to severe fatigue. Ipsilateral intensity‐modulated radiotherapy (OR: 0.18;p = 0.014) was associated with lower risk of reporting moderate to severe fatigue.ConclusionsOur study identified thyroid problems, smoking, and late lower cranial neuropathy as associated with moderate to severe fatigue. These findings should be further validated in prospective studies to address fatigue among OPC survivors.
Streamflow uncertainty due to the limited sensitivity of controls at hydrometric stations
Authors: Horner Ivan , Le Coz Jérôme , Renard Benjamin , Branger Flora , Lagouy Mickaël 
Published: January 2022

AbstractStreamflow data measured at hydrometric stations are affected by uncertainty due to water level (or stage) measurement errors. This uncertainty increases as the sensitivity of the stage‐discharge controls decreases. A recently proposed method is used to demonstrate the role of control sensitivity in propagating stage uncertainty to streamflow uncertainty among other error sources. The method is first applied to a fictitious hydrometric station with five alternative scenarios of controls with variable sensitivity. The fictitious controls are designed on a flat weir without or with triangular or rectangular notches. The method is also evaluated using a real hydrometric station where the initially flat weir was changed to a weir with a rectangular notch. Both applications confirm the importance of the sensitivity of the controls, showing that a narrow notch in a flat control substantially reduces the uncertainty of daily, monthly and yearly discharges as well as the uncertainty of a low flow index. Quantifying such uncertainty component is essential to optimize the design of hydrometric stations and to provide streamflow data with acceptable uncertainty, especially for low flows.
Difference matrices with four rows over generalized dihedral groups
Authors: Pan Rong , Abel R. Julian R. , Bunjamin Yudhistira A. , Feng Tao , Wang Xiaomiao , Zhang Menglong 
Published: January 2022

AbstractLet be a finite group and let be an integer. A ‐difference matrix (DM) is a matrix with entries from , such that for all distinct rows and , the multiset of differences contains each element of exactly once. Let be a finite abelian group and let be the generalized dihedral group of . It is proved that a ‐DM exists if and only if is of even order and is not isomorphic to . Also for the nine non‐abelian groups of order 16, we obtain ‐DMs over five of them, ‐DMs over three of them and a ‐DM over one of them. No ‐DM exists for this last group, where .
Investigating the role of dystrophin isoform deficiency in motor function in Duchenne muscular dystrophy
Authors: Chesshyre Mary , Ridout Deborah , Hashimoto Yasumasa , Ookubo Yoko , Torelli Silvia , Maresh Kate , Ricotti Valeria , Abbott Lianne , Gupta Vandana Ayyar , Main Marion , Ferrari Giulia , Kowala Anna , Lin Yung‐Yao , Tedesco Francesco Saverio , Scoto Mariacristina , Baranello Giovanni , Manzur Adnan , Aoki Yoshitsugu , Muntoni Francesco 
Published: January 2022

AbstractBackgroundDuchenne muscular dystrophy (DMD) is caused by DMD mutations leading to dystrophin loss. Full‐length Dp427 is the primary dystrophin isoform expressed in muscle and is also expressed in the central nervous system (CNS). Two shorter isoforms, Dp140 and Dp71, are highly expressed in the CNS. While a role for Dp140 and Dp71 on DMD CNS comorbidities is well known, relationships between mutations expected to disrupt Dp140 and Dp71 and motor outcomes are not.MethodsFunctional outcome data from 387 DMD boys aged 4–15 years were subdivided by DMD mutation expected effects on dystrophin isoform expression; Group 1 (Dp427 absent, Dp140/Dp71 present, n = 201); Group 2 (Dp427/Dp140 absent, Dp71 present, n = 152); and Group 3 (Dp427/Dp140/Dp71 absent, n = 34). Relationships between isoform group and North Star ambulatory assessment (NSAA) scores, 10 m walk/run velocities and rise time velocities were explored using regression analysis.Western blot analysis was used to study Dp427, Dp140 and Dp71 production in myogenic cells (control and DMD human), control skeletal muscle, DMD skeletal muscle from the three isoform groups and cerebral cortex from mice (wild‐type and DMD models). Grip strength and rotarod running test were studied in wild‐type mice and DMD mouse models. DMD mouse models were mdx (Dp427 absent, Dp140/Dp71 present), mdx52 (Dp427/Dp140 absent, Dp71 present) and DMD‐null (lacking all isoforms).ResultsIn DMD boys, mean NSAA scores at 5 years of age were 6.1 points lower in Group 3 than Group 1 (P < 0.01) and 4.9 points lower in Group 3 than Group 2 (P = 0.05). Mean peak NSAA scores were 4.0 points lower in Group 3 than Group 1 (P < 0.01) and 1.6 points lower in Group 2 than Group 1 (P = 0.04).Mean four‐limb grip strength was 1.5 g/g lower in mdx52 than mdx mice (P = 0.003) and 1.5 g/g lower in DMD‐null than mdx mice (P = 0.002).Dp71 was produced in myogenic cells (control and DMD human) and skeletal muscle from humans in Groups 1 and 2 and mdx mice, but not skeletal muscle from human controls, myogenic cells and skeletal muscle from humans in Group 3 or skeletal muscle from wild‐type, mdx52 or DMD‐null mice.ConclusionsOur results highlight the importance of considering expected effects of DMD mutations on dystrophin isoform production when considering patterns of DMD motor impairment and the implications for clinical practice and clinical trials. Our results suggest a complex relationship between dystrophin isoforms expressed in the brain and DMD motor function.
Graphs with no induced house nor induced hole have the de Bruijn–Erdös property
Authors: Aboulker Pierre , Beaudou Laurent , Matamala Martı́n , Zamora José 
Published: January 2022

AbstractA set of points in the plane which are not all collinear defines at least distinct lines. Chen and Chvátal conjectured in 2008 that a similar result can be achieved in the broader context of finite metric spaces. This conjecture remains open even for graph metrics. In this article we prove that graphs with no induced house nor induced cycle of length at least 5 verify the desired property. We focus on lines generated by vertices at distance at most 2, define a new notion of 'good pairs' that might have application in larger families, and finally use a discharging technique to count lines in irreducible graphs.
Diagnosis of inborn errors of metabolism within the expanded newborn screening in the Madrid region
Authors: Martín‐Rivada Álvaro , Palomino Pérez Laura , Ruiz‐Sala Pedro , Navarrete Rosa , Cambra Conejero Ana , Quijada Fraile Pilar , Moráis López Ana , Belanger‐Quintana Amaya , Martín‐Hernández Elena , Bellusci Marcello , Cañedo Villaroya Elvira , Chumillas Calzada Silvia , García Silva María Teresa , Bergua Martínez Ana , Stanescu Sinziana , Martínez‐Pardo Casanova Mercedes , Ruano Miguel L. F. , Ugarte Magdalena , Pérez Belén , Pedrón‐Giner Consuelo 
Published: January 2022

AbstractWe present the results of our experience in the diagnosis of inborn errors of metabolism (IEM) since the Expanded Newborn Screening was implemented in our Region. Dried blood samples were collected 48 h after birth. Amino acids and acylcarnitines were quantitated by mass spectrometry (MS)/MS. Newborns with alterations were referred to the clinical centers for follow‐up. Biochemical and molecular genetic studies for confirmation of a disease were performed. In the period 2011 to 2019, 592 822 children were screened: 902 of them were referred for abnormal results. An IEM was confirmed in 222 (1/2670): aminoacidopathies: 89 hyperphenylalaninemia (HPA) (51 benign HPA, 32 phenylketonuria, 4 DNAJC12 defect, and 2 primapterinuria), 6 hypermethioninemia, 3 tyrosinemia type 1 (TYR‐1), 1 TYR‐3, 4 maple syrup urine disease (MSUD), 2 branched‐chain amino acid transferase 2 deficiency, 2 homocystinuria, 1 cystinuria, 2 ornithine transcarbamylase (OTC) deficiency, 2 citrullinemia type I (CTLN1); FAO defects: 43 medium‐chain acyl‐CoA dehydrogenase deficiency (MCADD), 13 very long‐chain acyl‐CoA dehydrogenase deficiency, 2 long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency (LCHADD), 1 multiple acyl‐coA dehydrogenation deficiency, 11 systemic primary carnitine deficiency, 2 carnitine palmitoyltransferase type 2 (CPT‐II) deficiency, 1 CPT‐I deficiency; organic acidurias: 12 glutaric aciduria type 1 (GA‐1), 4 methylmalonic acidemia (MMA), 7 MMA including combined cases with homocystinuria (MMAHC), 6 propionic acidemia (PA), 7 3‐methylcrotonyl‐CoA carboxylase, 1 3‐hydroxy‐3‐methylglutaryl‐CoA lyase deficiency lyase deficiency. Only 19 infants (8.5%) were symptomatic at newborn screening result (1 LCHADD, 5 PA, 1 CPT‐II deficiency, 1 MMA, 3 MMAHC, 2 MSUD, 2 OTC deficiency, 1 CTLN1, 1 MCADD, 2 TYR‐1). No false negative cases were identified. Genetic diagnosis was conclusive in all biochemically confirmed cases, except for two infants with HPA, identifying pathogenic variants in 32 different genes. The conditions with the highest incidence were HPA (1/6661) and MCAD deficiencies (1/13 787).
Hypermagnesemia and feeding intolerance in preterm infants: A cohort study
Authors: Junqueira Elibene Orro , Marba Sergio Tadeu Martins , Caldas Jamil Pedro de Siqueira 
Published: January 2022

AbstractBackgroundFeeding intolerance (FI) is a common clinical problem in preterm infants often caused by some neonatal disorders and drugs, including antenatal exposure to magnesium sulfate (MgSO4).ObjectiveTo evaluate the association between hypermagnesemia at birth and FI in preterm infants during the first 72 h of life.MethodThis was a cohort study conducted with preterm infants aged <34 weeks' gestation. Infants presenting at least two of the following signs were considered as having FI: vomiting, abdominal distension, the need for continuous intermittent feeding, and delayed meconium passage. Hypermagnesemia was characterized by umbilical serum Mg levels > 2.5 mEq/L.ResultsA total 251 infants were evaluated. The median birth weight and gestational age were 1390 g (IQR, 1020–1070) and 31 weeks (IQR, 28–32). The FI rate was 17.5%. The exposure rate to MgSO4 was similar in the tolerant and intolerant groups (53.1% × 63.6%; P = 0.204), but hypermagnesemia was more frequent in the FI group (40.9% × 24.2%; P = 0.024). The univariate analysis showed that infants with hypermagnesemia were twofold more likely to present FI (odds ratio [OR], 2.16; 95% CI, 1.09–4.26). In the multiple logistic regression analysis, we found that hypermagnesemia was independently associated with FI (OR, 2.51; 95% CI, 1.06–5.91), as well as maternal diabetes mellitus (OR, 2.56; 95% CI, 1.07–6.14), Score for Neonatal Acute Physiology‐Perinatal Extension II (OR, 1.051; 95% CI, 1.025–1.078), and brain hemorrhage (OR, 3.61; 95% CI, 1.31–9.91).ConclusionIn addition to other factors, hypermagnesemia at birth was independently associated with early FI in preterm infants.
Application of Raman spectroscopy technology based on deep learning algorithm in the rapid diagnosis of glioma
Authors: Tian Xuecong , Chen Cheng , Chen Chen , Yan Ziwei , Wu Wei , Chen Fangfang , Chen Jiajia , Lv Xiaoyi 
Published: January 2022

AbstractMedical diagnosis technology based on convolutional neural networks (CNNs) has achieved good performance. In this study, we collected serum samples from 38 glioma patients and 45 healthy controls and used partial least squares (PLS) analysis to reduce the dimension of the data. Different levels of noise were added to the reduced data onto data augmentation, and the AlexNet, ResNet, and GoogLeNet fine‐tuning models were applied for classification. To evaluate the performance of the models, we used five‐fold cross‐validation. The accuracy rates of the AlexNet, ResNet, and GoogLeNet fine‐tuning models were 98.50%, 98.24%, and 99.50%, respectively. The model with the best classification effect was GoogLeNet. The specificity and sensitivity of this model were 98.98% and 98.48%, respectively. In addition, the area under the receiver operating characteristic (ROC) curve (AUC) of the established diagnostic model was 0.9949. The results showed that the combination of serum Raman spectroscopy and the PLS‐Gaussian‐GoogLeNet model achieved a good diagnostic effect for glioma. This method has high clinical application value and is worthy of further popularization.
Type‐1 Laryngeal Cleft and Pathogenic Bacterial Growth in the Lower Airway in Children
Authors: Ha Tu‐Anh N. , Ongkasuwan Julina , Spielberg David R. , Zhu Huirong , Das Shailendra 
Published: January 2022

Objectives/HypothesisThe purpose of this study is to evaluate the association between type‐1 laryngeal clefts and pathogenic bacterial growth in the lower airway in children.Study DesignRetrospective chart review.MethodsA retrospective chart review was conducted for all children who underwent direct laryngoscopy, flexible bronchoscopy with bronchoalveolar lavage (BAL), and esophagogastroduodenoscopy, under a single anesthetic event from 2015 until 2018 at an academic tertiary referral center. Type‐1 laryngeal clefts were diagnosed as an interarytenoid depth at or below the level of the vocal folds, on direct laryngoscopy, via palpation by a fellowship‐trained pediatric otolaryngologist. Pathogenic bacterial growth in the lower airway was defined as presence of BAL culture growth of nonrespiratory flora.ResultsA total of 217 patients were identified. Type‐1 laryngeal cleft was significantly associated with chronic cough (P = .0016) and cough with feeds (P < .0001). However, an abnormal video fluoroscopic swallow study was not found to be significantly associated with type‐1 laryngeal cleft (P = .92) or pathogenic bacterial growth in the lower airway (P = 0.19).Overall, 122 (56%) patients were diagnosed with type‐1 laryngeal cleft, 75 (35%) had pathogenic bacterial growth in the lower airway and 50 (23%) had both type‐1 laryngeal cleft and pathogenic bacterial growth in the lower airway. Type‐1 laryngeal cleft was significantly associated with pathogenic bacterial growth in the lower airway on both univariate analysis (P = .0307) and multivariate analysis (P = .0298, odds ratio 1.922, 95% confidence interval 1.066–3.467).ConclusionChildren with type‐1 laryngeal clefts are at higher risk of having pathogenic bacterial growth in the lower airway.Level of Evidence4 Laryngoscope, 132:1825–1828, 2022
Reply to comment: Controls on turnover of marine dissolved organic matter—testing the null hypothesis of purely concentration‐driven uptake
Authors: Shen Yuan , Benner Ronald 
Published: January 2022

AbstractOur recent bioassay experiments indicate that molecular properties are a primary control on the microbial utilization of dissolved organic matter in the ocean. This finding is questioned by Lennartz and Dittmar who modeled our experiments and concluded that our observations could be largely explained by concentration‐driven uptake independent from molecular properties. We suggest the authors' models are deficient for establishing the relative roles of molecular properties and concentration‐driven uptake. Our conclusion is consistent with earlier and recent experimental results and biogeochemical observations, supporting a unified theory with molecular properties as a more prominent control than concentration‐driven uptake on marine organic carbon accumulation.
Preparation and performance evaluation of an ester‐bridged antioxidant used as multifunctional additive in ester oil
Authors: Jin Yongliang , Li Jian , Lee Weimin , Cheng Bingxue , Jia Dan , Tu Jiesong , Zhan Shengpeng , Yang Tian , Duan Haitao 
Published: January 2022

AbstractThis study aims to investigate a novel high‐efficient antioxidant for synthetic ester oils. An ester‐bridged antioxidant, phloroglucinol tris (3‐[3,5‐di‐tert‐butyl‐4‐hydroxyphenyl]) propionate (PTP), was successfully synthesised in high yield under relatively mild reaction conditions. Thermal stability and oxidation resistance of diisooctyl adipate (DOA) ester oil were determined and compared to the typical commercial phenol antioxidants, including its tribological properties. The results indicate that the prepared PTP antioxidant exhibits considerably higher thermal stability than commercial antioxidants, and it also improves the oxidation resistance of the synthetic ester oil more effectively. Moreover, the addition of PTP antioxidant enhanced the wear protection of DOA ester oil without deteriorating its lubricating performance. The ester‐bridged antioxidant can be used as a multifunctional additive, which not only exerts excellent thermal stability and oxidation resistance, but can also act as an efficient anti‐wear agent in synthetic ester oils.
Programmable Anisotropic Hydrogel Composites for Soft Bioelectronics
Authors: Fu Linzheng , Gao Tinghao , Zhao Weiwei , Hu Sanming , Liu Li , Shi Zhijun , Huang Jin 
Published: January 2022

AbstractFabrication of hydrogel composites embedded with aligned 1D nanoparticles has shown substantial growth over the past 5 years. Direct ink printing technology (DIW) has been used in this work to create the alignment of the 1D nanoparticles due to the shear gradient of the pseudoplastic precursor (2‐hydroxyethyl methacrylate (HEMA) with thickening agents). Orderly distributed 1D particles constructing anisotropic nanostructures endow the hydrogel composite with unique mechanical, electric, or electromechanical coupling properties. Quasi‐static uniaxial tensile test, electric resistivity, and piezoresistivity measurements have been conducted for investigating the mechanical, electric, and electromechanical coupling properties of the hydrogel composites, respectively. Based on the experimental results, it can be speculated that the developed printing process is able to fabricate hydrogel composites with programmable anisotropic mechanical, electric, and electromechanical properties. The products pumped out from this work have the potential of being substrates for soft devices and may have a great impact on the fields of flexible bioelectronics.