bluuebunny/crossref_metadata_2025_split huggingface dataset:
Behavior of hydrogen defect and framework of Fe-bearing wadsleyite and ringwoodite at high temperature and high pressure
Authors: Jin Yang , Huang Weihua , Wang ZhongPing , Sun Wei , Liu Yan , Xia Qunke , Yang Yan 
Published: September 2022

Abstract
The transition zone is dominated by polymorphs of olivine, wadsleyite, and ringwoodite, which are to date considered the main water carriers in the Earth’s mantle. Despite considerable studies on water solubility and its impact on physical properties of the two minerals, knowledge of their hydrogen defects and framework behavior at high temperature and high pressure is still lacking. Here, we systematically assess this issue, by in situ high-temperature (20–800 °C) infrared spectroscopic studies, in situ high-temperature (20–800 °C) and high temperature-pressure (14.27 and 18.84 GPa, 20–400 °C) Raman spectroscopic studies on the iron-bearing wadsleyite and ringwoodite. The results show that dehydrogenation in wadsleyite happens at a higher temperature than in ringwoodite. The infrared absorption patterns of hydrogen defects in wadsleyite and ringwoodite are temperature sensitive, resulting from hydrogen defects transfer and site-specific stabilities. As for the framework, it is more sensitive to temperature and pressure for ringwoodite than wadsleyite. These results provide new knowledge about hydrogen defects and framework of wadsleyite and ringwoodite at high temperature and high pressure, which is indispensable for understanding water solubility and its impacts on physical properties of these two minerals.
Numerical modelling of breaking wave impact loads on a vertical seawall retrofitted with different geometrical configurations of recurve parapets
Authors: Ravindar R. , Sriram V. , Salauddin M. 
Published: September 2022

Abstract
Experiments are the traditional techniques used in coastal engineering to study complex wave structure interactions. However, with the advent of high-performance computing, even performing 1:1 scale numerical simulations has become a reality. The progress aids in extending the parametric investigation or repeating the procedure for comparable structures. In this study, a numerical model in OpenFOAM® with waves2Foam wave boundary conditions is used to simulate wave structure interactions at seawalls with varied geometrical configurations of recurved parapets. The numerical model is validated by employing ForschungsZentrum Küste (FZK)'s large-scale (1:1) experiments. The validated model is then applied to the plain parapet and vertical wall to understand better overtopping behaviour, pressure distribution, and structural loads. Numerical modelling is used in this study to visualise and assess intrinsic parameters such as the velocity profile, vorticity, air entrapment, and entrainment better to understand the dissipation characteristics of seawalls with recurved parapets.
Wound Healing: An Overview of Wound Dressings on Health Care
Authors: Sadeghi-Aghbash Mona , Rahimnejad Mostafa , Adeli Hassan , Feizi Farideh 
Published: September 2022

Abstract:
Chronic wound healing is a time-consuming and complicated process. Severe risk for
wound healing that can be life-threatening is bacterial invasion and wound during the healing process.
Therefore, it is necessary to use a sui barrier to create a controlled environment for wound healing.
Various wound dressings such as hydrocolloids, hydrogels, sponges, foams, films, and micro and nanofibers
have been explored in recent decades. High surface-to-volume ratio, high similarity to the
biological structure of the extracellular matrix, high porosity and very small pore size are some advantages
of nanofibers that have become potential candidates for wound healing applications. Different
methods are used to fabricate nanofibers like drawing-processing, template synthesis, self-assembly,
phase separation, force-spinning and electrospinning. Electrospinning is the most desirable method
due to the possibility of producing independent, accessible and controllable nanofibers. The fiberbased
wound dressings and their manufacturing methods have been extensively discussed.
Targeted Mitochondrial Drugs for Treatment of Ischemia-Reperfusion
Injury
Authors: Yi Guang-Hui , Peng Jin-Fu , Salami Oluwabukunmi Modupe , Habimana Olive , Xie Yu-Xin , Yao Hui 
Published: September 2022

Abstract:
Ischemia-reperfusion injury is a complex hemodynamic pathology that is a leading cause of death worldwide and occurs in many body organs. Numerous studies have shown that mitochon-dria play an important role in the occurrence mechanism of ischemia-reperfusion injury and that mi-tochondrial structural abnormalities and dysfunction lead to the disruption of the homeostasis of the whole mitochondria. At this time, mitochondria are not just sub-organelles to produce ATP but also important targets for regulating ischemia-reperfusion injury; therefore, drugs targeting mitochondria can serve as a new strategy to treat ischemia-reperfusion injury. Based on this view, in this review, we discuss potential therapeutic agents for both mitochondrial structural abnormalities and mito-chondrial dysfunction, highlighting the application and prospects of targeted mitochondrial drugs in the treatment of ischemia-reperfusion injury, and try to provide new ideas for the clinical treatment of the ischemia-reperfusion injury.
Simvastatin Upregulates Lipoxin A4 and Accelerates Neuroinflammation
Resolution After Intracerebral Hemorrhage
Authors: Wu Yao , Shi Xia , Zhang Jianbo , Hao Na , Li Wei , Chen Qianwei , Chen Zhi , Feng Hua 
Published: September 2022

Background:
Previous studies have demonstrated that statins have the effect of relieving inflammatory brain injury after intracerebral hemorrhage (ICH), but the mechanisms remain poorly characterized. This study aims to test whether simvastatin exerts an anti-inflammatory effect through regulating the pro-resolving mediators.

Methods:
First, male Sprague–Dawley rats had an injection of 200 μL autologous blood. Then, rats were randomly divided into groups treated with simvastatin (i.p. 2 mg/kg) or vehicle. Next, all rats underwent pro-resolving mediator lipoxin A4 (LXA4) level detection, flow cytometric, immunofluorescence, brain edema measurement, neurological scoring and western blot analysis.

Results:
We found that simvastatin significantly increased the plasma level of LXA4, an endogenous formyl-peptide receptor 2 (FPR2) agonist, in the early stage of ICH. Consistent with the effect of simvastatin, exogenous LXA4 administration also promoted apoptosis of the circulating neutrophils, reduced neutrophils brain-infiltration, and ameliorated inflammatory brain injury after ICH. In addition, similar to simvastatin, exogenous LXA4 markedly decreased the level of phosphorylated p38 mitogen-activated protein kinase (MAPK) and the apoptosis-related proteins myeloid cell leukemia 1(Mcl-1)/Bax ratio (a decreased ratio represents the induction of apoptosis) in circulating neutrophils isolated from ICH rats. Notably, all of the aforementioned effects of simvastatin on ICH were significantly abolished by Boc-2, a selective antagonist of FPR2. Moreover, simvastatin led to a similar Mcl-1/Bax ratio reduction as SB203580 (a p38 MAPK inhibitor), but it was abolished by P79350 (a p38 MAPK agonist).

Conclusion:
Collectively, these results suggest that simvastatin ameliorates ICH-mediated inflammatory brain injury, possibly in part by upregulating the level of pro-resolving mediator LXA4 and further stimulating the FPR2/p38 MAPK signaling pathway.
DFT and In-silico Investigations, along with In-vitro Antitumor and Antimicrobial
Assessments of Pharmacological Molecules
Authors: Afifi Tarek H. , Naqvi Arshi , Alsehli Mosa H. , Seth Daya S. , El-Gaby Mohamed S.A. , Okasha Rawda M. , Hagar Mohamed 
Published: September 2022

Background:
Molecules, bearing an active methylene bridge, are deemed to be one of the most fruitful and remarkable precursors that have been incorporated in the synthetic strategy of an assortment of bioactive compounds.

Objective:
The reactive methylene derivatives have been endowed with multiple reactions, which target biological and medicinal applications and are resultant from their structural multiplicity and discrete reactivity.

Methods:
The present report endeavors to synthesize, characterize, and in-vitro evaluate several novel propanoic acid, coumarin, and pyrazole derivatives as antimicrobial and antiproliferative agents. The in-silico molecular docking, physicochemical, pharmacokinetic/ADMET, bioactivity, and drug likeness predictions were conducted for all the synthesized compounds.

Results:
The highest docking score is -9.9 and -8.3 kcal/mol respectively for compound 9 (azo-coumarin) and 13 (acrylic acid derivative) with the target proteins E. coli topoisomerase II, DNA gyrase subunit B and PI3K p110α domain, respectively. Moreover, this study predicts the synthesized molecules that may inhibit the novel COVID-19, obtained through virtual screenings only, where compounds 9, 13, 14, 17, and 19 came to the limelight with good docking scores i.e more than 8 Kcal/mol. Safety profiling of the most potent compound 9 was utilized against normal cell line and hemolytic effect on RBCs.

Conclusion:
The in-silico ADMET studies of the synthesized compounds revealed moderate to good drug likeness, high gastro intestinal (GI) absorption, inhibits the Cytochrome CYP2C19 and CYP2C9 and all the derivatives possess non-cancerous nature. The in-vitro screening demonstrated that several of the novel molecules are promising drug candidates. The density function theory (DFT) theoretical calculations were performed to calculate the energy levels of the FMOs and their energy gabs, dipole moment as well as the molecular electrostatic potential. Such parameters along with the physicochemical parameters could be good tool to confirm the biological activity.
Recent Patents of Pharmaceutical Co-Crystals: Product Development on
Anti-Cancer Drugs and Beyond
Authors: Tharik Abdul Azeeze Mohamed Sheik , Meyyanathan Subramania Nainar 
Published: September 2022

Background:
Scientists, academicians, and researchers from academics and the pharmaceutical
industries have all expressed interest in the design and production of pharmaceutical
cocrystals in recent years. The development of novel drug products with enhanced physicochemical
and pharmacological characteristics is aided by the cocrystallization of drug substances.

Objective:
The major problem with drug candidates is their solubility and bioavailability, which
may be solved with the appropriate molecular modifications. The failure of most drug candidates
in earlier clinical trials is also reawakening interest. In that connection, pharmaceutical cocrystals
are vital in the development of dosage forms in the field of pharmaceutical technology. The goal
of this manuscript is to provide a comprehensive overview of cocrystal synthesis methods and
characterization techniques.

Conclusion:
In this review, it is evident that the solvent-free technique has several benefits over
solvent-based approaches in the design and production of pharmaceutical cocrystals, and that these
methodologies can also open opportunities for further advancement in the field of cocrystal synthesis.
This manuscript provides a brief overview of each technique for manufacturing pharmaceutical
cocrystals and an analysis of cocrystals. This manuscript has highlighted points on whether
cocrystals comply with the requirements for intellectual property rights and how they will impact
the current pharmaceutical industry. The impact of recent patents on pharmaceutical cocrystals is
examined in depth with relevant examples.
mHealth Technologies for Managing Problematic Pornography Use: Content Analysis
Authors: Henry Nathan , Donkin Liesje , Williams Matt , Pedersen Mangor 
Published: September 2022

Background
Several mobile apps are currently available that purportedly help with managing pornography addiction. However, the utility of these apps is unclear, given the lack of literature on the effectiveness of mobile health solutions for problematic pornography use. Little is also known about the content, structure, and features of these apps.

Objective
This study aims to characterize the purpose, content, and popularity of mobile apps that claim to manage pornography addiction.

Methods
The phrase “pornography addiction” was entered as a search term in the app stores of the two major mobile phone platforms (Android and iOS). App features were categorized according to a coding scheme that contained 16 categories. Apps were included in the analysis if they were described as helpful for reducing pornography use, and data were extracted from the store descriptions of the apps. Metrics such as number of user ratings, mean rating score, and number of installations were analyzed on a per-feature basis.

Results
In total, 170 apps from both app stores met the inclusion criteria. The five most common and popular features, both in terms of number of apps with each feature and minimum possible number of installations, were the ability to track the time since last relapse (apps with feature=72/170, 42.4%; minimum possible number of installations=6,388,000), tutorials and coaching (apps with feature=63/170, 37.1%; minimum possible number of installations=9,286,505), access to accountability partners or communities (apps with feature=51/170, 30%; minimum possible number of installations=5,544,500), content blocking or content monitoring (apps with feature=46/170, 27.1%; minimum possible number of installations=17,883,000), and a reward system for progress (apps with feature=34/170, 20%; minimum possible number of installations=4,425,300). Of these features, content-blocking apps had the highest minimum possible number of installations. Content blocking was also the most detected feature combination in a combinatorial analysis (with 28 apps having only this feature), but it also had the lowest mean consumer satisfaction rating (4.04) and second-lowest median rating (4.00) out of 5 stars. None of the apps reviewed contained references to literature that provided direct evidence for the app’s efficacy or safety.

Conclusions
There are several apps with the potential to provide low- or zero-cost real-time interventions for people struggling to manage problematic pornography use. Popular app features include blockers of pornographic content, behavior monitoring, and tutorials that instruct users how to eliminate pornography use. However, there is currently no empirical evidence to support the effectiveness and safety of these apps. Further research is required to be able to provide recommendations about which apps (and app features) are safe for public consumption.
The Practicality of Geometry Learning Media based on Augmented Reality
Authors: Munir Nilam Permatasari , Anas Aswar , Suryani Lilis , Munir Fairus Suryani 
Published: September 2022

Abstract:Augmented reality geometry applications are developed based on today's learning needs, AR is able to present visualizations of building spaces from the virtual world to the real world through the android camera to the marker. The purpose of this study was to determine the practicality of geometry learning media assisted by the AR android application. This type of research is descriptive quantitative, with a practical questionnaire research instrument. The population of this study were all students of the mathematics study program, 408 students with a simple random sampling technique of 30 students. The technique of analyzing the practicality test data is descriptive statistical analysis. The results show that geometry learning media based on AR android by paying attention to the 6 (six) practical aspects, namely aspects of learning design, media display, software, materials, and benefits are in the very practical category, with a percentage of 94 %. This shows that AR media is very practical for learning.Abstrak:Aplikasi geometri augmented reality dikembangkan berdasarkan kebutuhan pembelajaran dimasa kini. AR mampu menghadirkan visualisasi bangun ruang dari dunia maya ke dunia nyata melalui kamera android ke marker. Penelitian ini bertujuan untuk mengetahui praktikalitas media pembelajaran bangun ruang sisi datar berbantuan aplikasi android AR. Jenis penelitian ini adalah deskriptif kuantitatif, dengan instrumen penelitian angket praktikalitas, populasi dalam penelitian ini adalah seluruh mahasiswa program studi pendidikan matematika sebanyak 408 orang dengan teknik pengambilan sampel simple random sampling sebanyak 30 orang. Teknik analisis data uji praktikalitas yaitu analisis statistic deskriptif. Hasil penelitian ini menunjukkan bahwa media pembelajaran bangun ruang sisi datar berbantuan aplikasi Android AR dengan memperhatikan ke-6 (enam) aspek praktikalitas yaitu aspek desain pembelajaran, tampilan media, software, materi, dan manfaat, berada pada kategori sangat praktis, dengan persentase sebesar 94%. Hal ini menunjukkan media AR ini sangat praktis digunakan dalam pembelajaran.
Identifikasi Kemampuan Literasi Matematika Ditinjau Dari Perspektif Kecerdasan Logis Matematis
Authors: Allo Nursia Manu , Yusuf Munir , Arifanti Dwi Risky , Naflatunnisa Winayati , Syaifullah M 
Published: September 2022

Abstract:Mathematical literacy skills and mathematical logical intelligence are essential things that students must have to be able to use mathematics in everyday life. This study aims to identify mathematical literacy skills from the perspective of logical-mathematical intelligence of junior high school students in Towuti, East Luwu. This type of research is descriptive qualitative with data collection techniques for mathematical logical intelligence tests and tests of mathematical literacy skills and interview guidelines. The indicators used adopt indicators developed by Stecey and Turner. The research subjects used were three categories of students from class VIII room 2 who had high, medium, and low mathematical logical intelligence. The results showed that students with high mathematical logical intelligence were able to identify all indicators of mathematical literacy ability so that they had high mathematical literacy skills. It is different for students with moderate and low logical intelligence, who have low and high literacy abilities. The results of this identification are still possible to continue by an analytical study. Abstrak:Kemampuan literasi matematika dan kecerdasan logis matematis merupakan hal yang penting dimiliki siswa agar mampu menggunakan matematika dalam kehidupan sehari-hari. Penelitian ini bertujuan mengidentifikasi kemampuan literasi matematika ditinjau dari perspektif kecerdasan logis matematis siswa tingkat SMP di Towuti Kabupaten Luwu Timur. Penelitian ini bersifat kualitatif deskriptif dengan instrumen tes kecerdasan logis matematis, tes kemampuan literasi matematika, dan pedoman wawancara. Indikator yang digunakan mengadopsi teori Stecey dan Turner. Subjek penelitian adalah siswa dari kelas VIII ruangan 2 dengan kecerdasan logis matematis tinggi, sedang dan rendah. Hasil penelitian menunjukkan siswa dengan kecerdasan logis matematis tinggi mampu mengidentifikasi semua indikator kemampuan literasi matematika dengan baik dan memiliki kemampuan literasi matematika tinggi. Hal berbeda untuk siswa dengan kecerdasan logis sedang dan rendah. Hasil identifikasi ini masih memungkinkan untuk ditindaklanjuti dengan suatu penelitian yang bersifat analisis.
АКСІОЛОГІЧНИЙ ПІДХІД ДО ПРОФЕСІЙНОЇ ПІДГОТОВКИ МАЙБУТНІХ ФАХІВЦІВ У ГАЛУЗІ КУЛЬТУРИ І МИСТЕЦТВ
Authors: Шетеля Наталія 
Published: September 2022

Формуванню ціннісно-смислової сфери й аксіологічної культури особистості сприяє її залучення до аксіологічного знання й світу цінностей. Вказане визначає наукову цікавість до практичного залучення в систему професійної підготовки аксіологічного підходу. Запропоноване авторське бачення щодо концептуальних перспектив звернення до вказаного підходу для формування професійної культури (зокрема, аксіологічної) майбутніх фахівців галузі культури і мистецтв.
У роботі обстоюється думка, що професійна підготовка майбутніх фахівців відповідного профілю повинна включати цілеспрямоване формування у них системи внутрішніх, емоційно освоєних професійних цінностей, які допоможуть їм впоратися зі складними соціокультурними проблемами під час здійснення професійної діяльності.
THE PROBLEM OF THE RUSSIAN WORLD IN RUSSIAN SOCIAL PHILOSOPHY OF THE XI-XXI CENTURIES
Authors: Теплых Никита Валерьевич 
Published: September 2022

Духовная ситуация времени в современной системе отношений «человек - общество» является критической. Обращение к истокам российской духовно-нравственной культуры, отечественным историко-культурным традициям, духовно-нравственным ценностям, которые унаследовали современные граждане России, способно преодолеть этот кризис. Осмысление традиций и ценностей не только оптимизирует и систематизирует современный процесс развития русской национальной культуры самосознания, но и способствует выработке продуктивного алгоритма к формированию диалога энотрадиций. Исторический опыт взаимодействия разных народов, осуществляющийся мирным путем, характерный для многих регионов нашей страны, имеет глобальное, общечеловеческое значение. Возможно, столь долго искомое «высшее предназначение России», о котором задумывались многие выдающиеся мыслители, состоит именно в поиске и нахождении формулы гармоничного взаимосвязанного и взаимообуславливающего существования разных этносов.
The spiritual situation of time in the modern system of relations «man - society» is critical. Appeal to the origins of Russian spiritual and moral culture, domestic historical and cultural traditions, spiritual and moral values that modern citizens of Russia have inherited, can overcome this crisis. Comprehension of traditions and values not only optimizes and systematizes the modern process of development of the Russian national culture of self-consciousness, but also contributes to the development of a productive algorithm for the formation of a dialogue of ethnic traditions. The historical experience of interaction between different peoples, carried out in a peaceful way, characteristic of many regions of our country, is of global, universal significance. Perhaps the long-sought «higher destiny of Russia», which many prominent thinkers thought about, consists precisely in the search and finding a formula for a harmonious interconnected and mutually conditioning existence of different ethnic groups.