bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time-resolved laser-induced incandescence on metal nanoparticles: Effect of nanoparticle aggregation and sintering
Authors: Robinson-Enebeli S. , Talebi-Moghaddam S. , Daun K. J. 
Published: August 2022

Abstract
This work examines the excessive absorption and anomalous cooling phenomena reported in laser-induced incandescence measurements on metal nanoparticles by considering the effects of aggregate structure and sintering. Experimental investigations are conducted on iron and molybdenum aerosols, which have different melting points and thus respond differently to the laser pulse. Although aggregation enhances the absorption cross-section of the nanoparticles and allows for higher peak temperatures, this enhancement does not fully explain the observed excessive absorption. Furthermore, as the aggregates of refractory metals such as molybdenum cool, they may sinter through gradual grain boundary diffusion; this change in structure alters their absorption cross-section, manifesting as a rapid drop in the pyrometric temperature, which could explain the anomalous cooling reported for this metal.
7-Geranyloxcycoumarin enhances radiosensitivity in human prostate cancer cells
Authors: Abolhassani Yasaman , Nejabat Masoud , Talebian Seyedehsaba , Gholamhosseinian Hamid , Rassouli Fatemeh B. , Jamialahmadi Khadijeh 
Published: August 2022

Abstract
Background: Prostate cancer is the second most prevalent and the sixth deadliest cancer among men worldwide. To improve the efficacy of radiotherapy on prostate cancer cells, we investigated the apoptosis-inducing effects of ionizing radiation (IR) in combination with auraptene (AUR). Methods and Results: PC3 cells were pretreated with various concentrations of the synthesized AUR and then were exposed to IR. After recovery, the viability of cells was determined by alamarBlue assay. Flow cytometric analysis with annexin V and propidium iodide was performed to assess apoptosis induction. Cell viability assay indicated that the toxicity of IR was enhanced by AUR, which was also confirmed by an increased number of apoptotic cells. The expression of P53, BAX, BCL2, GATA6, and CCND1 was analyzed by quantitative polymerase chain reaction (qPCR). qPCR demonstrated significant overexpression of P53 and BAX, while the expression of BCL2, GATA6, and CCND1 was significantly downregulated. Conclusion: These findings suggest that AUR is able to improve the apoptosis-inducing effects of IR in prostate cancer cells. Thus, this combinatorial treatment could be considered as a potential approach for further investigations.
DYNLL1 transcript abundance decreases during oocyte and follicular growth and is associated with fertility in mice
Authors: BERKEL Caglar , CACAN Ercan 
Published: August 2022

Abstract
DNA repair efficiency is an important determinant of oocyte quality and female fertility. DYNLL1 (Dynein light chain 1) plays a part in DNA double-strand break (DSB) repair choice by promoting t error-prone non-homologous end joining (NHEJ) repair and in contrast by limiting accurate and error-free homologous recombination (HR) repair. Here, we showed that DYNLL1 transcript abundance decreases gradually during oocyte and follicular growth in mice. In parallel,DYNLL1 mRNA transcript levelsdeclinesin the course of oocyte meiotic maturation in mice. Furthermore, our in silico analysis showed that ovaries from high-fertility mice with increased ovulation have decreased DYNLL1 transcript abundance compared to that of control mice. Similarly, we found that the induction of ovulation with human chorionic gonadotropin (hCG) decreases DYNLL1 mRNA transcript levels in cumulus oocyte complexes in mice. We hypothesize that this decrease in DYNLL1 transcript abundance during oocyte and follicular growth and in ovulation might lead to relatively higher error-free HR repair and lower error-prone NHEJ repair events in mice, resulting in increased genome stability. Increased genome stability in mice with lower DYNLL1 levels might also contribute to better fertility performance. This paper highlights the need for further in vivo and mechanistic studies to better understand the role of DYNLL1 in the maintenance of oocyte reserve and in oocyte quality and fertility.
Comorbidities in patients with uterine adenosarcoma. A single-center case series of 12 patients
Authors: Du Hui , Jiang Jingjing , Wang Zhu , Peng Hongfa 
Published: August 2022

Abstract
Background
Uterine adenosarcoma is a rare low-grade tumor that commonly affects elderly women and is associated with a generally good, although sometimes poor, prognosis. This study investigates the effect of comorbidities in old patients with uterine adenosarcoma.
Methods
A review of patients who had been diagnosed with uterine adenosarcoma at our institution between 2010 and 2020 was conducted. All patients underwent a specialist pathological review and were re-staged according to the International Federation of Gynecology and Obstetrics 2009 criteria. Patient demographics, staging, histologic features, primary and adjuvant therapy, disease recurrence, and survival time were collected.
Results
Twelve patients with confirmed uterine adenosarcomas were identified. Their mean age at diagnosis was 58.3 years (range, 31–83 years). Eight patients had pre-existing chronic diseases at the time of diagnosis. All 12 patients underwent surgical therapy. Of these, 10 (83.3%) were stage I, 1 (8.3%) was stage II, and 1 (8.3%) was stage III. Postoperative adjuvant therapies included chemotherapy (n = 1), radiation (n = 1), or no further therapy (n = 10). The mean follow-up duration was 39.2 months (range, 7–104 months). The recurrence and mortality rates were 16.7% (2/12) and 41.7% (5/12), respectively. Five recurrence-free patients died of comorbidities. The mean postoperative survival of these 5 patients was 22.6 months. The remaining seven patients were free of recurrence at the time of this report.
Conclusions
Comorbidities with age is a significant factor leading to poor prognosis in uterine adenosarcomas. Greater attention should be paid to elderly patients with comorbidities. Targeted interventions, including multi-professional management, tailored assessment, and follow-up, may contribute to improved well-being.
Gamma-delta T cells modulate the microbiota and fecal micro-RNAs to maintain mucosal tolerance
Authors: Rezende Rafael , Cox Laura , Moreira Thais , Liu Shirong , Boulenouar Selma , Dhang Fyonn , Leserve Danielle , Nakagaki Brenda , Lopes Juliana , Tatematsu Bruna , Lemos Luisa , Mayrink Julia , Lobo Eduardo , Guo Lydia , Kuhn Chantal , Weiner Howard 
Published: August 2022

Abstract
BackgroundGamma-delta (γδ) T cells are a major cell population in the intestinal mucosa and are key mediators of mucosal tolerance and microbiota composition. Little is known about the mechanisms by which intestinal γδ T cells interact with the gut microbiota to maintain tolerance.ResultsWe found that antibiotic treatment depleted intestinal γδ T cells and impaired oral tolerance, suggesting that the gut microbiota is necessary to maintain γδ T cells. We also found that mice deficient for γδ T cells (γδ−/−) developed a microbial dysbiosis that led to small intestine (SI) inflammation and impaired tolerance. Accordingly, colonizing WT mice with γδ−/− microbiota resulted in SI inflammation and loss of tolerance whereas colonizing γδ−/− mice with WT microbiota ameliorated inflammation and restored mucosal tolerance. Moreover, we found that SI γδ T cells shaped the gut microbiota and regulated intestinal homeostasis by secreting the fecal micro-RNA let-7f. Importantly, oral administration of let-7f to γδ−/− mice decreased inflammation and rescued mucosal tolerance by promoting the growth of the γδ−/− microbiota depleted microbe Ruminococcus gnavus.ConclusionsTaken together, we demonstrate that γδ T cell-selected microbiota is necessary and sufficient to promote mucosal tolerance, which is mechanistically linked to γδ T cell secretion of fecal micro-RNAs.
On the fractal properties of Cosmic Rays and Sun Dynamics Cross-Correlations
Authors: Porta David Sierra 
Published: August 2022

Abstract
We investigate the cosmic rays and ten physical parameters of heliosphere behavior considering the scaling features of their temporal evolution. Our analysis start with the cosmic rays measurements by a neutron monitor station located in Moscow, as well sunspot, Ap index, Na/Np, Alfven mach number, DST index, Kp index, Plasma beta β, Proton temperature, F10.7 index and Field magnitude B (Interplanetary Magnetic Field, IMF), for the period 1976 to early 2020. Each of these datasets was analyzed by using the Multifractal Detrended Fluctuation Analysis and Multifractal Detrended Cross-Correlation Analysis in order to investigate intrinsic properties, like self-similarity and the spectrum of singularities. The main result obtained is that the cosmic rays time series as well the 10 hiospheric parameters exhibit positive long-range correlations with multifractal behavior.
Rubric co-construction in medical and allied health education: Students’ and teachers' perceptions
Authors: Kilgour Andrew , Morton Jason , Cloete Linda , Dawson Sonja , Northcote Maria 
Published: August 2022

Abstract

[100 to 250 words] The process of constructing assessment rubrics has traditionally been the responsibility of academic staff who teach into undergraduate university degrees. While many educational researchers and theorists have long recommended the need for students and teachers to work together to co-construct assessment rubrics, few empirical studies have explored the reality of such partnerships. Furthermore, past studies have recommended engaging higher education students in various stages of assessment. Many have focused particularly on the mid and latter stages of the assessment process, including the preparation of assessment submissions and the distribution and interpretation of assessment feedback, but neglect earlier involvement. To address this gap, this study engaged students and teachers in the early stage of assessment design, at the point where assessment rubrics are created. Using a mixed methods approach, students and teachers from three health-related cohorts were surveyed and interviewed after rubric co-construction, and again after use of the co-constructed rubric, to document their experiences. Overall, students and teachers recommended the practice of co-construction, valued the experience, and in the process, gained more insight into each others’ needs. Students benefited by understanding what was required of them in their assessment tasks, and teachers were provided with opportunities to clarify their learning expectations.
Expression of complexes I, II and IV in the SGNs of noise-stimulated rats was decreased, and mitochondrial energy metabolism was disturbed, mediating the damage and degeneration of SGNs
Authors: Ding Zhong-Jia , Wang Yin , Wang Ren-Feng , Mi Wen-Juan , Qiu Jian-Hua , Zha Ding-Jun 
Published: August 2022

Abstract
Noise-induced hearing impairment can mediate delayed injury of spiral neurons (SGNs), resulting in degeneration of nerve fibers, synaptic degeneration and even death of SGNs. We believe that delayed injury is related to mitochondrial energy metabolism disorders. Therefore, we investigated ATP and the electron transport chain (ETC) in rat SGNs after noise injury and found that with prolonged injury time, ATP synthesis and the expression of complexes II and IV decreased, indicating the functional decline of the ETC. The maintenance of ETC function is related to subunit import and assembly of the complex. The disulfide relay mechanism controlled by the apoptosis inducing factor/coiled-coil-helix-coiled-coil-helix domain-containing protein 4(AIF/CHCHD4) pathway can regulate mitochondrial protein import. The results showed that AIF expression in SGNs decreased after noise exposure, indicating that noise damage to SGNs can restore intramitochondrial protein input by downregulating the AIF/CHCHD4 pathway, hindering ETC function; insufficient ETC function is a possible reason for the delayed injury of SGNs.
Neurally adjusted ventilatory assist improves respiratory mechanics in patients with intra-abdominal hypertension
Authors: Kang Xiuwen , Zhang Chenying , Wang Wan , Hu Rong , Mu Zhifang , Li Yong , Shen Yeju , Liu Suxia , Gu Caihong , Xu Huiling 
Published: August 2022

Abstract
Neurally Adjusted Ventilatory Assist (NAVA) is a new ventilator mode, which collects the electrical activity of diaphragm (EAdi) and provides proportional pressure. The relationship between intra-abdominal hypertension (IAH) and EAdi still needs to be elucidated. The aim of our study was to investigate the effect of EAdi on IAH and to assess whether NAVA is a suitable ventilation mode for patients with IAH.The patients were divided into non-IAH-NAVA (NIAH-NAVA) group (10 cases), IAH-NAVA group (10 cases), and IAH-PSV group (10 cases). The asynchrony index was also recorded for 30 minutes after enrollment. After 24 hours, the intra-abdominal pressure (IAP), EAdi, NAVA level, positive end-expiratory pressure (PEEP), static lung compliance (CSt), plateau pressure (Pplat), airway pressure (Paw), driving pressure (Pdriv), respiratory rate (RR), tidal volume (VTi), pH, PaO2, PaCO2, and oxygenation index (OI) values were monitored. We also recorded the duration of mechanical ventilation and the length of ICU stay. Patients with IAH had lower EAdi values, and there was a negative correlation between them. In patients with IAH, the NAVA level values were higher, the CSt value was lower, and the Pplat, Paw, PEEP and Pdriv values were increased. Compared with the PSV group, the CSt value was increased and the Pplat, Paw, PEEP and Pdriv values were reduced in the NAVA group. RR value was higher in patients with IAH, while VTi value was reduced. In the NAVA group, the asynchrony index was lower than that in the PSV group. In patients with IAH, the duration of mechanical ventilation in the NAVA group was shorter than that time in the PSV group, however, the length of ICU stay had no differences between the two groups. Our study found a negative correlation between IAP and EAdi. the NAVA level values were higher, the CSt value was lower, and the Pplat, Paw, PEEP and Pdriv values were increased in patients with IAH.However, NAVA could be used to improve respiratory mechanics and reduce the duration of mechanical ventilation in patients with IAH, also improve the asynchrony. Trial registration: Registered in Clinical Trials under number ChiCTR1900022218 and approved by the Ethics Committee of The First' People’s Hospital of Lianyungang, protocol number ky20180520001.
Towards the sustainable decommissioning of fixed platforms by aligning ecosystem services and wind generation: a Brazilian case
Authors: Barboza Douglas Vieira , Meiriño Marcelo Jasmim , Barros Sérgio Ricardo da Silveira 
Published: August 2022

Abstract
Brazilian legislation, as well as others around the world, determines that oil platforms, mainly fixed, must be decommissioned at the end of the feasibility of exploring the oil field, however, it is not common to consider the loss of ecosystem services that sustain life, the biodiversity and make resources available to humans. Considering the importance of the ecosystems that developed in the substructures of platforms, this work proposes a solution to maintain ecosystem services together with the development of clean, economically viable wind energy generation. For this, a proposal is built based on climatological, geographic, and wind power generation market data that seeks to demonstrate the financial viability of the specific case of the Robalo 1 Platform, which is located about 50 kilometers from other platforms to be decommissioned, in the Sergipe-Alagoas Basin, Brazil. It was found that when minimally valuing ecosystem services such as artificial reefs and integrating wind generation for the sustainable decommissioning of the fixed platform substructure. From the point of view of net present value, the project proves to be viable.
Patient engagement in balanced scorecard and the influence of patient experiences on their attitudes- An implication at Palestinian hospitals
Authors: Amer Faten , Neiroukh Haroun , Abuzahra Sa’ed Enan , AlHabil Yazan , Afifi Mufeeda , Shellah Duha , Boncz Imre , Endrei Dóra 
Published: August 2022

Abstract
Introduction
The balanced scorecard (BSC) was implemented to improve hospitals’ performance evaluations (PE) in the last 30 years. BSC consists of six perspectives: financial, customer, internal, external, knowledge and growth, and managerial. However, patients were seldom engaged in such implementations. This research aims to engage Palestinian patients in BSC implementations.
Methodology
This is a cross-sectional study. We collected data between January and October 2021 using the printed BSC-PATIENT survey. We evaluated the patients’ experiences and attitudes toward BSC dimensions (BSCP ATT). The differences in evaluations based on admission status were also analyzed using the Mann‒Whitney U test. Additionally, we analyzed the causal relationships between patients’ experiences and attitudes using multiple linear regression, and the multicollinearity of the model was tested. Finally, the path analysis was performed to understand the BSC strategic maps based on the Palestinians’ evaluations.
Results
The mean scores for Palestinian patient experiences evaluation showed that the services experience factor had the highest score (87.7 ± 17.7), and the patient care experience factor had the lowest score (57 ± 34.5). The patient experiences collectively predicted 56.4% of the variance in the BSCP ATT. The experiences factors of information (β = 0.400, t = 13.543, P < 0.001), patient care (β = 0.241, t = 8.061, P < 0.001), services (β = 0.176, t = 6.497, P < 0.001), and building (β = 0.177, t = 6.308, P < 0.001) had the highest impact on BSCP ATT. The price had only a weak negative influence (β=-0.051, t=-2.040, P = 0.042). Accessibility to hospitals did not have any impact on BSCP ATT. Significant differences between inpatient and outpatients’ evaluations in regard to experiences related to patient care (P = 0.042), services (P < 0.001), accessibility (P < 0.001), and BSCP ATT (P = 0.003) were found.
Conclusion
Managers of Palestinian hospitals should prioritize enhancing the patient experience, particularly the information experience. The importance of patient education programs and information sharing with patients cannot be overstated. Other experiences as patient care, services, and building are also significant. By focusing on separate evaluations of patients' experiences and attitudes, the BSC strategic maps will be easier to understand from the patients' point of view. BSC-PATIENT survey may assist hospitals managers in achieving this objective and enhancing their action plans. Palestinian hospitals must enhance patients’ feedback and engagement culture.
Host or pathogen primed bacterial consortia alters microbial community structures in Arabidopsis roots and suppresses Fusarium oxysporum
Authors: Kudjordjie Enoch Narh , Sapkota Rumakanta , Nicolaisen Mogens 
Published: August 2022

AbstractBackground: The plant-associated microbiota confers beneficial traits to the plant host that promote growth and prevents disease. It is, however, not fully understood how the host, and pathogens, modulate the assembly of the associated microbiota. In this work, we investigated the effects of inoculation with bacterial consortia (BCs) that had been primed with either the host plantArabidopsis thalianaalone or by a combination of the host and the pathogenFusarium oxysporumf. sp.mathioli(FOM), on the root-associated microbiota and FOM. We used 16S rRNA and ITS amplicon sequencing for profiling root bacterial and fungal communities, respectively. qPCR was employed for the assessmentof FOM quantities in the shoots ofArabidopsis.Results:Our results showed distinct effects of host or pathogen primed BCs on microbial community structures and networks. The host-primed BCs inhibited FOM proliferation in shoots, distinctively affected rhizo-microbial community structures and further enhanced the connectivity of the microbial networks. Beneficial bacterial genera includingFlavobacterium,Azospirillum,MassiliaandPedobacterwere significant biomarkers in the samples inoculated with host-primed BCs and could potentially be involved in FOM antagonism. Likewise, FOM-primed BCs reduced FOM in the shoots ofArabidopsisand altered microbial networks. Bacterial taxa Bacteriodetes,Flavobacteriumand Chthoniabacteraceae and the fungal,Exophialaand Phaeosphaeriaceae were the most enriched biomarker taxa in the samples treated with FOM-primed BCs. Moreover, the host genotype effect was significant in overall microbial community network structuring and could contribute to resistance to FOM pathogens.Conclusions:Altogether, these findings deepen our understanding of both host- and pathogen-priming on plant-associated microbiomes, thus, revealing pivotal engineering routes in exploring microbiomes to manage plant diseases.
Security Enhancement and PaaS platform Authentication in Cloud Computing based On SBA
Authors: Vankdothu Ramdas , Hameed Mohd Abdul 
Published: August 2022

Abstract
One of the most challenging security requirements in a PaaS platform setting is authentication. We provide a new signature-based authenticated key establishment approach for PaaS platform security improvement in this study. It adds a feature to increase confidentiality and non-repudiation by requiring the sender to sign a specific action while sending data from one user to another. It’s signed with the transaction’s private key and a public-key value-based signature generated with the transaction’s public key. Use the public key value-based signature that was generated to authenticate this operation, and the hashing process assures that the operation is immutable. Our proposed solution delivers improved data security, throughput, reaction speed, and a reduction in end-to-end delay and overhead when compared to existing methodologies. The results of the experiments reveal that the proposed system achieves a superior outcome to the existing methods. This project makes use of the MATLAB platform.
Jurisprudence and the Emergence of the Auxiliary Sciences of History in the 16th-18th Centuries
Authors: Логинов А.В. , Щекочихина М.А. 
Published: August 2022

В статье рассматривается возникновение метода критики источников в Раннее Новое время. Поскольку возникновение критики грамот было вызвано необходимостью определять юридическую подлинность документов, она испытала сильнейшее влияние права. Делается вывод о влиянии норм Corpus Iuris Civilis на дискуссии об определении подлинности документов в трактатах юристов и учёных-эрудитов, занимавшихся определением подлинности грамот как исторических источников.
The article focuses on the emergence of the method of historical criticism in the Early Modern Age. Since the emergence of criticism was caused by the need to determine authenticity of documents, it experienced the strongest influence of law. The article concludes about the influence of the Corpus Iuris Civilis norms on the discussions regarding the determination of the authenticity of documents in the treatises of lawyers and scholars, who were specifically engaged in determining the authenticity of letters as historical sources.