bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of the Effect of High-Intensity Interval Training (HIIT) on the Expression of the Genes miR-126, miR-296, HGS and VEGF-A Protein Levels in Tumor Tissue in Female Mice
Authors: Farsi S , Ghaedi H , Nasiri Ivanaki M 
Published: February 2022

Background & Objective: The studies of the last two decades have shown that regular training is associated with the reduction of mortality among patients with breast cancer, and has an important role in inhibiting breast cancer progression as well as treatment of the disease. However, the micro-molecular mechanisms involved are not fully understood yet. However, the aim of the present study was to investigate the effect of a high-intensity interval training (HIIT) on the expression of miR-126, miR-296, HGS gene, and VEGF-A protein level in tumor tissue of the mice with breast cancer.
Materials & Methods: For this purpose, 12 BALB/c mice (6-8 weeks, weight 19 ± 1.05 g), after induction of cancer (MC4-L2 subcutaneous injection into the right side of the mice), were randomly divided into two groups with 6 in each group: HIIT and control. Each session of HIIT group program includes six intervals of three minutes and 20 seconds with an intensity of 85 to 90 percent of VO2max and 1-minute recovery with 30 to 35 percent VO2max intensity between each interval; and the animals were sacrificed 24 hours after the last training session and the expression of miR-126, miR-296, HBS gene and VEGF protein levels in tumor tissues were examined.
Results: The statistical results showed that the implementation of HIIT significantly reduced the expression of miR-296 and subsequently increased the HGS gene expression and led to increased expression levels of miR-126 and decreased levels of VEGF-A protein in the training group compared to the control group (p<0.05).
Conclusion: It seems that HIIT, by suppressing tumor angiogenesis signaling pathways, could be an effective intervention to inhibit the growth of breast tumors.
Using breakout rooms in online language teaching: Advantages and disadvantages
Authors: Mirzoeva Leila Yurievna 
Published: February 2022

Under the conditions of the pandemic, language teachers face a variety of challenges on effective ways of teaching. Current literature has purported the effectiveness of breakout rooms being an effective method of teaching language online. The purpose of this study was to identify whether online teaching tools help students to study language and keep them being motivated, or not. To study the impact of breakout rooms application, the following participants were chosen: 3 groups of second-year IT students whose level of English is considered as Pre-Intermediate; the total number of students was 34. The study conducted classes in 2 experimental groups using the breakout rooms option, and in 1 controlling group where breakout rooms were not used. Data was collected using semi-structured interviews. The findings of this study show that students’ opinion concerning breakout rooms application was rather positive; thus, they focus on the opportunities for brainstorming in breakout rooms.

Keywords: breakout rooms; business English; online learning; students’ motivation
Functional Limitations, Post-Traumatic Stress Disorder, and College Adjustment in Student Veterans: A Mediation Analysis Study
Authors: Umucu Emre , Rumrill Phillip , Chiu Chung-Yi , Ghosh Arpita 
Published: February 2022

PurposeThe purpose of this study was to examine whether functional limitations mediate the relation between PTSD symptoms and college life adjustment in student veterans with PTSD symptoms.MethodsA total of 232 student veterans with PTSD symptoms were recruited for this study. Participants were predominantly male (84.5%; females = 15.5%). Participants’ ages ranged from 18 to 54 years (M = 28.43, SD = 5.42). Correlational analyses were conducted to calculate the relationships among study variables. We also conducted a mediation analysis to examine whether functional limitations mediate the relationship between PTSD symptoms and college life adjustment.ResultsThe mediation analysis indicated that the effect of PTSD symptoms on college adjustment can be partially explained by functional limitations.ConclusionOur results have potentially important implications for rehabilitation counseling researchers and clinicians in the COVID-19 era.
Modeling the responses of Coffee (Coffea arabica L.) distribution to current and future climate change in Jimma Zone, Ethiopia
Authors: Chalchissa Fedhasa Benti , Diga Girma Mamo , Tolossa Alemayehu Regassa 
Published: February 2022

<em>Coffee arabica</em> species have already been affected by climate change, with socioeconomic implications. Smallholder farmers have encountered and will continue to confront issues in maintaining their coffee plants' productivity. This study aimed to determine which bio-climatic characteristics are most beneficial to coffee production in current and future climate change scenarios. The responses of coffee distribution to climatic conditions were studied under the current, moderate representative concentration (RCP4.5), and worst representative concentration (RCP8.5) pathways using a bioclimatic modelling approach or the Maxent model. Multiple regression models (path and response optimizers) were used to parameterize and optimize the logistic outputs of plant distribution. Results showed that climatic factors such as total precipitation, precipitation seasonality, and mean temperature are the most important climatic factors in determining the success of <em>C. arabica</em> farming. Under the current conditions, total precipitation significantly benefits <em>C. arabica</em> whereas precipitation seasonality significantly affects it (P &lt; 0.001). In the current condition, coffee responded neither negatively nor positively to the mean temperature, but positively in RCP4.5 and RCP8.5. It would also respond positively to increased total precipitation under RCP4.5 but negatively to rising precipitation under the RCP8.5. The average five top-optimal multiple responses of <em>C. arabica</em> were 75.8, 77, and 70% for the present, RCP4.5, and RCP8.5, respectively. The positive response of <em>C. arabica</em> to bioclimatic variables in the RCP4.5 scenario is projected to be much bigger than in the present and RCP4.5 scenarios (P &lt; 0.001). As precipitation and temperature-related variables increase, the cultivation of <em>C. arabica</em> will increase by 1.2% under RCP4.5 but decrease by 5.6% under RCP8.5. A limited number of models and environmental factors were used in this study, suggesting that intensive research into other environmental aspects is needed using different models.
Hubungan Antara Efikasi Diri (Self Efficacy) dengan Kepuasan Hidup (Life Satisfaction) Mahasiswa
Authors: Nabila Tessa , Wahyuni Eka 
Published: February 2022

Penelitian ini bertujuan untuk melihat apakah ada hubungan positif antara efikasi diri dan kepuasan hidup pada mahasiswa Fakultas Ilmu Pendidikan Universitas Negeri Jakarta. Penelitian ini menggunakan metode penelitian kuantitatif dengan teknik pengambilan sample yaitu incidental sampling. Sample penelitian berjumlah 361 mahasiswa Fakultas Ilmu Pendidikan Universitas Negeri Jakarta. Penelitian ini menggunakan alat ukur dalam bentuk kuesioner yaitu General Self Efficacy Scale untuk variabel efikasi diri dan Multidimensional Students’ Life Satisfaction Scale untuk variabel kepuasan hidup. Pada variabel efikasi diri mahasiswa Fakultas Ilmu Pendidikan Universitas Negeri Jakarta memiliki tingkat efikasi diri sedang dan ditandai dengan jumlah persentase 64% dengan aspek tertinggi yaitu pada aspek effort dengan persentase 32%. Sedangkan pada variabel kepuasan hidup berada pada kategori sedang dan digambarkan dengan persentase 50% dan aspek tertinggi ada pada family dengan persentase sebesar 23%. Semua uji coba dalam penelitian ini menggunakan tingkat signifikansi .05. Secara umum terdapat hubungan antara efikasi diri dengan kepuasan hidup dengan hasil uji korelasionel yaitu hasil .398 uji korelasi ini masuk pada kategorisasi rendah sehingga hubungan antara kedua variabel tidak begitu signifikan. Dapat disimpulkan bahwa terdapat hubungan positif yang tidak signifikan antara efikasi diri dengan kepuasan hidup mahasiswa Fakultas Ilmu Pendidikan
Pengaruh Model Pembelajaran Creative Problem Solving dalam Pembelajaran Jarak Jauh terhadap Kemampuan Pemecahan Masalah Matematis Siswa SMP Negeri 3 Jakarta
Authors: Naila Nur Fadhila  
Published: February 2022

Tujuan dari penelitian ini adalah untuk menguji pengaruh model pembelajaran Creative Problem Solving dalam pembelajaran jarak jauh terhadap kemampuan pemecahan masalah matematis siswa SMP Negeri 3 Jakarta. Penelitian ini mempergunakan metode quasi-experiment dengan posttest-only control group design. Teknik pengambilan sampel dengan two stage random sampling menggunakan cluster random sampling dan simple random sampling. Instrumen yang dipergunakan ialah tes kemampuan pemecahan masalah matematis pada materi perbandingan berupa 4 soal uraian yang telah diuji validitas dan reliabilitasnya. Berdasar pada hasil analisis data mempergunakan uji-t didapatkan sebesar 3,765 dan sebesar 1,665 sehingga tolak H0 dengan taraf signifikansi dengan nilai Cohen’s effect size senilai 0,858 yang terhimpun pada kategori besar dengan persentase 79%. Dengan demikian, dapat dipaparkan bahwa terdapat pengaruh signifikan dari model pembelajaran Creative Problem Solving terhadap kemampuan pemecahan masalah matematis siswa dalam PJJ di SMP Negeri 3 Jakarta pada materi perbandingan.
Pengaruh Model Pembelajaran CORE (Connecting, Organizing, Reflecting, Extending) terhadap Kemampuan Koneksi Matematis Siswa di SMP Negeri 206 Jakarta
Authors: Nugroho Sigit Galih 
Published: February 2022

Penelitian ini bertujuan untuk mengetahui apakah terdapat pengaruh signifikan penerapan model pembelajaran CORE (Connecting, Organizing, Reflecting, Extending) terhadap kemampuan koneksi matematis siswa. Penelitian ini dilakukan pada siswa kelas delapan di SMP Negeri 206 Jakarta semester genap tahun ajaran 2019/2020 pada materi Pythagoras. Metode penelitian yang digunakan adalah quasi experimental design (eksperimen semu). Pengambilan sampel menggunakan teknik simple random sampling. Teknik simple random sampling dilakukan dengan memilih secara acak dua dari empat kelas berdistribusi normal, homogeny, dan memiliki kesamaan rata-rata untuk dijadikan sebagai kelas eksperimen (model pembelajaran CORE (Connecting, Organizing, Reflecting, Extending)) dan kelas kontrol (model pembelajaran konvensional). Instrument penelitian yang digunakan adalah tes kemampuan koneksi matematis pada materi Pythagoras sebanyak 4 soal uraian. Sebelum digunakan, instrument tersebut telah melalui uji validitas isi, validitas konstruk, dan validitas empiris. Perhitungan reliabilitas dilakukan menggunakan rumus Alpha Cronbach dan diperoleh koefisien reabilitas sebesar yang termasuk dalam kategori tinggi. Berdasarkan perhitungan data hasil penelitian, data kedua kelas berasal dari populasi berdistribusi normal dan memiliki varians yang sama atau homogen. Oleh karena itu, pengujian hipotesis statistik dilakukan menggunakan statistik uji-t dengan varians yang sama. Berdasarkan hasil pengujian hipotesis diperoleh nilai , yang artinya tolak pada taraf signifikansi . Dengan demikian dapat disimpulkan bahwa terdapat pengaruh signifikan model pembelajaran CORE (Connecting, Organizing, Reflecting, Extending) terhadap kemampuan koneksi matematis siswa SMP Negeri 206 Jakarta pada materi Pythagoras dengan taraf signifikansi 0,05.
ANALYSIS OF MATHEMATIC HIGH ORDER THINKING SKILLS (HOTS) PROBLEMS BASED ON COGNITIVE LEVEL INDICATORS ON BLOOM TAXONOMY
Authors: LIA AMALIA  
Published: February 2022

Abstract. This study aims to analyse the questions of high order thinking skills in the Statistics chapter in 2013 curriculum Mathematics textbook which are measured based on indicators of cognitive levels in Bloom's taxonomy. The object of this study is the questions in the Statistics chapter in the Mathematics textbook which is 3 questions. The question analysis technique is based on problem solving with details of competency standards, question indicators, HOTS indicators, Questions and Answer Keys.

Keywords: High Order Thinking Skills, Statistics, Bloom's Taxonomy
Exposure to Inclusive Language and Well-Being at Work Among Transgender Employees in Australia, 2020
Authors: Perales Francisco , Ablaza Christine , Elkin Nicki 
Published: February 2022

Objectives. To provide empirical evidence of the positive effects of exposure to inclusive language on trans employees’ well-being. Methods. We leveraged unique data from a large Australian national survey of workplace diversity and inclusion (2020 Australian Workplace Equality Index Employee Survey), focusing on a subset of trans respondents (n = 453). We derived self-reported and aggregate-level measures of exposure to trans-inclusive language and created a multidimensional index of employee well-being. We examined their relationships using fully adjusted random-intercept multilevel regression models. Results. We found strong, positive, and statistically significant associations between different indicators of exposure to inclusive language at work and trans employees’ well-being. These relationships were large in magnitude and emerged in the presence of an encompassing set of sociodemographic and workplace controls, including other markers of workplace diversity and inclusion (e.g., victimization experiences and identity disclosure). Conclusions. Our results provide robust evidence indicating that efforts to foster inclusive language at work can yield substantial, positive effects on trans people’s feelings of belonging and inclusion, thereby contributing to their overall socioeconomic integration. (Am J Public Health. 2022;112(3):482–490. https://doi.org/10.2105/AJPH.2021.306602 )
Shoulder Periprosthetic Joint Infection and All-Cause Mortality: A Worrisome Association
Authors: Austin Daniel C. , Townsley Sarah H. , Rogers Thomas H. , Barlow Jonathan D. , Morrey Mark E. , Sperling John W. , Sanchez-Sotelo Joaquin 
Published: February 2022

Background:
Periprosthetic joint infection (PJI) can be a devastating complication following shoulder arthroplasty. PJI following hip and knee arthroplasties has been found to increase mortality. However, anatomical and bacteriologic differences could potentially result in a different trend after shoulder arthroplasties. Thus, the purpose of the present study was to determine whether there is an association between shoulder PJI and all-cause mortality.

Methods:
Our institutional Total Joint Registry Database was queried to identify patients who underwent revision shoulder arthroplasty procedures between 2000 and 2018. A total of 1,160 procedures were then classified as either septic (21.8%) or aseptic (78.2%). Septic revisions were further subdivided into (1) debridement, antibiotics, irrigation, and implant retention (9.1%); (2) 2-stage reimplantation for deep infection (61.3%); (3) implant resection without reimplantation (3.6%); and (4) unexpected positive cultures at revision surgery (26.1%). The most common bacterium isolated was Cutibacterium acnes (64.4%). All-cause patient mortality was determined with use of our registry and confirmed with use of a nationwide mortality database. All-cause crude and adjusted mortality rates were then compared between groups.

Results:
The 1-year crude mortality rate was 1.8% (95% confidence interval [CI], 0.9% to 2.6%) for the aseptic group and 2.8% (95% CI, 0.7% to 4.8%) for the septic group (p = 0.31). Multivariate Cox regression analysis demonstrated an elevated but statistically similar adjusted hazard ratio for 1-year all-cause mortality of 1.9 (95% CI, 0.8 to 4.6) when comparing the septic to the aseptic group (p = 0.17). The risk of 2-year all-cause mortality was significantly higher in the septic group, with a hazard ratio of 2.2 (95% CI, 1.1 to 4.5; p = 0.029). In univariate analyses, increased 5-year mortality in the septic revision group was associated with age, Charlson Comorbidity Index, and methicillin-resistant Staphylococcus aureus infection, whereas C. acnes infection was associated with lower mortality.

Conclusions:
Shoulder PJI is associated with an adjusted 2-year all-cause mortality rate that is double that of aseptic patients. The results of the present study should be utilized to appropriately counsel patients who are considered to be at risk for infection following shoulder arthroplasty.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Improving high school students’ conceptual understanding of electricity and magnetism using scaffold analogy instructions
Authors: Mengistu Aysheshim , Assefa Shimels , Gebeyehu Desta 
Published: February 2022

Simulated analogical teaching model has a novel contribution in enhancing students’ learning. This study aims to analyze effect of simulated analogies scaffold by group discussion model in improving students’ conceptual understanding of some selected contents of electricity and magnetism at high school level. The study involved 75 grade 10th students from two different high schools, namely Dagmawi Twodros and Fert high schools found in Debre Tabor Town, South Gondar, Amhara region, Ethiopia. A quasi-experimental method with pretest posttest design was used in the study. An adapted standardized test of electricity and magnetism conceptual understanding test (EMCUT) was used to collect data. The reliability of EMCUT was checked using KR-20 and found to be at about .81. After checking all necessary assumptions, an independent sample t-test was used to analyze the mean difference on students EMCUT scores between groups. From the result analysis, we found that experimental group who used simulated analogies scaffold by group discussion method in learning of electricity and magnetism showed a higher mean score of EMCUT than the control group. Thus, it can be concluded that the use of simulated analogies scaffold by group discussion model improved high school students’ conceptual understanding of electricity and magnetism.
Antenna Engineering for Various Applications with Low-Cost Product Manufacturing
Authors: M SURESH CHINNATHAMPY , Marzla Ancy 
Published: February 2022

Abstract
Antenna means for radiating radio waves, Generally the type of antenna that are used in cell phone handsets in the form of Sleeve dipoles, Whip antennas. In the sleeve dipoles we have a coaxial transmission line, dielectric insert, metal sleeve and line braid. The balancing mode can be achievable with metal sleeve also the stability of the radiation pattern. The role of the dielectric and sleeve are not only maintaining the radiation pattern stable but also walk on the matching. Whenever we have the roll over mobile it is used for getting signal as well as receive signal. Capturing of signal is possible when the mobile starts working. The system represents the capturing of omni directional signal through radiation pattern measurements. The coaxial line inner conductor is along the Z- direction, the signal is symmetric along X-Y plane.
In this chapter it is proposed to develop an antenna which can be used as low-cost product in various fields. The construction of the whip antenna must be compact. A spring in the whip antenna plays a vital role as small compact antenna systems which is usually implemented for cell phones. The small compact antenna used for transmitting and receiving signals in an omni-directional system. From the cell phone perspective technology, the printed technology made a significant role which helps in use meandered monopoles used in MEMS. In historical perspective, this complicated design has to concentrate on the types of frequency ranges covered with radiation pattern also we cannot estimate current in the antenna since it is an integrated device, the placement of the other things like a battery also carries power and we have to look into the arrangements in a design in such a way that we must estimate the power dissipation throughout the antenna circuit, we have to rectify if the current which flows through the conductor carries any additional effects. The overall structure of the mobile also affects the radiation pattern. The parasitic effects, nearby circuits, placement of the other devices in a mobile affects the electromagnetic energy distribution. Similarly in all the fields the antenna can be developed with low-cost product manufacturing.
Micro-Line Investigation in Titanium Dioxide Thin Film Coated on TiNi Alloy by Indirect Microscopy
Authors: Yadav Nagendra Prasad , Hu Guozhen , Xu Bin 
Published: February 2022

Abstract
Titanium Dioxide thin film was synthesized on Titanium Nickelide alloy by using sol-gel spin coating method. Nowadays, it is a big issue to investigate the micro crack line in any thin film through the optical microscope for character the adhesion. The super-resolution microscope is better for evaluating the adhesion. The surface morphology of the film was studied using Scanning Electron Microscopy (SEM). Recently, only expensive and inconvenient non-optical method such as SEM (Scanning Electron Microscope) and TEM (Transmission Electron Microscope) are available for high resolution services. Here, we are reporting on the investigations of the crack line in titanium dioxide thin film coated on titanium nickelide alloy by Superresolution Parameter Indirect Microscopy Imaging. Furthermore, we found that the crack line can be seen in PIMI images whereas in SEM the crack line not seen clearly even the magnification of SEM is 10000X, which have been demonstrated by comparing the line intensity across the crack.
Impact of klotho on the expression of SRGAP2a in podocytes in diabetic nephropathy
Authors: Jin Donghua , Jia Miao , Xie Yuxian , Lin Lihua , Qiu Hong , Lu Guoyuan 
Published: February 2022

Abstract
Background Diabetic nephropathy (DN) is the major cause of renal failure, and glomerular podocytes play critical roles in the pathogenesis of DN by maintaining the glomerular structure and filtration barrier. Klotho and Slit-Robo GTP activating protein 2a (SRGAP2a) have been indicated to play protective roles in reducing renal injury, but whether there is an internal relationship between these two factors is unclear. Methods In this study, we cultured differentiated rat podocytes in vitro and measured the SRGAP2a expressions by immunofluorescence staining, quantitative real-time PCR (qRT-PCR) and western blotting, after siRNA-mediated transforming growth factor β1 (TGF-β1) silencing, TGF-β1 overexpression and in the presence of a reactive oxygen species (ROS) inhibitor. And we detected the expressions of SRGAP2a, small mother against decapentaplegic (Smad)2/3, phosphorylated-Smad2/3 (p-Smad2/3), Smad7, and NAD(P)H oxidase 4 (NOX4), ROS levels and podocyte cytoskeletal remodelling under high glucose (HG) and exogenous klotho conditions. In addition, we performed haematoxylin-eosin (HE) staining and immunohistochemistry with diabetic rat models to confirm the in vitro results. Results The results indicated that SRGAP2a expression was significantly upregulated under siRNA-mediated TGF-β1 silencing conditions or after adding a ROS inhibitor, but significantly downregulated with TGF-β1 overexpression, in the presence of HG. The supplementation of exogenous klotho under HG conditions significantly increased the SRGAP2a expression, remodelled the actin cytoskeleton and altered the expressions of Smad2/3, p-Smad2/3, Smad7 and NOX4 and reduced the ROS generation in podocytes. Moreover, klotho administration protected renal injury in DN rats. Conclusions This study indicated that klotho may modulate the expression of SRGAP2a by regulating the ROS and TGF-β1 signalling pathways and provided theoretical support for klotho protein as a novel therapeutic strategy for treating DN patients.