bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of a 5-Gene-Based Signature to Predict Prognosis and Correlate Immunomodulators for Rectal Cancer
Authors: Lin Yi , Ji Qiang , Peng Yichen , Yu Chunna , Zheng Yi , Kang Xun , Zheng Jianwei , Bai Rixing , Yan Wenmao , Wang Xiaomin , Li Wenbin 
Published: March 2022

Abstract
Background
Specific tumour markers that are similar to the 21-gene assay in breast cancer, have yet to be identified in rectal cancer. The objective of this study is to identify a novel genetic signature in rectal cancer to help predict survival and provide clues for immunotherapy.
Methods
Differentially Expressed Genes were obtained from two GEO datasets of rectal cancer. By using data from TCGA and GSE133057, two cohorts of rectal cancer were applied to establish and evaluate the prognostic signature. Then, a nomogram was constructed to estimate survival predictability in both training and validation cohorts. Subsequently, we integrated the risk-score with clinicopathological features and assessed its interplay with immune cells and molecules. Finally, our study performed functional annotations, gene-targeted miRNAs, and single-cell analysis to reveal potential functions and relevant mechanisms.
Results
A total of 468 DEGs were identified between rectal cancer and normal tissues, and a signature consisting of 5 genes (CLIC5, ENTPD8, PACSIN3, HGD, and GNG7) was selected for further analyses in a prognostic model. According to the risk-score calculated by the model, results showed that overall survival was significantly worse in the high-risk group (P = 0.0044). The model exhibited high performance in time-dependent ROC as well as a nomogram. Notably, as an independent prognostic factor, the risk-score was associated with vascular invasion (P = 0.038). Furthermore, there was a dramatic difference in nonregulatory CD4 + and CD8 + T cells between the high and low-risk groups. Strikingly, the Heat map plot showed that genes in our model were correlated with immune inhibitors. Moreover, there was also a big difference in autophagy-, immune-, cell cycle-, infection-, and apoptosis-associated terms and pathways between high and low-risk groups by GO and KEGG enrichment. Then, hsa-miR-6887 was predicted to be a common microRNA of 5 genes, which was only correlated with GNG7 in expression. Markedly, the functional states of differentiation, apoptosis, and quiescence were highly related to the 5-gene signature in single-cell analysis.
Conclusion
Our results suggest that the 5-gene-based signature could serve as a novel prognostic biomarker in rectal cancer, which could be of benefit for decision-making in rectal cancer immunotherapy.
Vinpocetine restores cognitive and motor functions in Traumatic brain injury challenged rats
Authors: Deshmukh Rahul , Kajal Kajal 
Published: March 2022

Abstract
Traumatic brain damage is common worldwide and the treatments are not defined. Vinpocetine is PDE1 inhibitor and reported to protect brain damage following various neurptoxic insults. Here in the current study we have investigated the neuroprotective potential of vinpocetine against traumatic brain injury. TBI was induced by Marmarou weight drop method in rats. Brain damage was evaluated using cognition, motor functions and alterations in biomolecules. Injured rats were treated with different doses of vinpocetine for four weeks. Traumatic brain injury in rats produced significant deteriotation of cognition and motor functions. Elevation in markers of oxidative stress, alterations in other monoamines were observed in injured rats, whereas vinpocetine treated rats showed significant recovery with improved alterations in cognitive and motor functions and also restored traumatic brain injury induced biochemical alterations. The observed neuroprotective potential of vinpocetine could be related to its antioxidant potential and its ability to frestore brain neurohemical alterations under stressful conditions.
Pancreatic stones formation in the pancreatic stent after central pancreatectomy: A case report
Authors: Gai Ying-Wen , Wang Huai-Tao , Tan Xiao-Dong 
Published: March 2022

Abstract
BackgroundPancreatic stenting is a common method to prevent pancreatic anastomosis stricture and pancreatic fistula after pancreaticoduodenectomy, pancreatectomy, and other pancreatic surgeries. Since the decomposition and digestive ability of pancreatic juice is strong, there is reportedly a low risk of stone formation in the tube. Case presentationA 68-year old female patient who was diagnosed with a pancreatic space occupying lesion was admitted to our department. Central pancreatectomy was performed with the insertion of an internal pancreatic stent, and the patient recovered well postoperatively. However, she was hospitalized again 1 year later with complains of exudation from the abdominal incision. Detailed clinical, imaging, and laboratory examinations revealed multiple stones in the pancreatic stent, which was the major cause of a pancreatic pseudocyst and pancreatitis. During the operation, we anastomosed the cyst to the jejunum and inserted another pancreatic stent without fixation in case of an anastomosis stricture or recurrence of pancreatic stones occurs. The patient was discharged 7 days postoperatively and no other complications were reported during the patient’s follow-up visit half a year later.ConclusionWe described a rare case of postoperative pancreatic stent stones complicated by chronic pancreatitis and pancreatic pseudocyst after central pancreatectomy. Application of pancreatic stent should be carefully evaluated considering its potential complication presented in this report.
CPT-Based Liquefaction Resistance of Clean and Silty Sands: A Drainage conditions Based Approach
Authors: Ecemis Nurhan , Monkul Mehmet Murat , Tütüncü Yunus Emre , Arik Mustafa Sezer 
Published: March 2022

Abstract
The cone penetration test-based simplified liquefaction triggering evaluations are largely based on linking liquefaction manifestations in the field to cone penetration resistance. These relationships are interpreted in such a way that for given penetration resistance, the liquefaction resistance increases as non-plastic fines content (FC) increases. However, several studies have indicated discrepancies in this relationship. Hence, there is a lag in rational scientific understanding of this observation. In this study, an experimental research program was undertaken to investigate the CPT-based liquefaction assessment by considering the effects of drainage conditions on the relationship between CPT resistance and liquefaction resistance. First, clean sand and silty sands having 5, 15, and 35% FC were tested at different relative densities by stress-controlled cyclic direct simple shear (CDSS) tests to investigate cyclic resistance of silty sand with varying amounts of non-plastic fines. Then, a set of tests involving piezocone penetration (CPTu), seismic CPTu (SCPTu), and direct push permeability (DPPT) were undertaken in a large-scale box filled with the same soils used in the CDSS tests. The large-scale test results quantified the effect of drainage conditions (coefficient of consolidation) on cone penetration resistance. Finally, by combining the CDSS and CPTu test results, an alternative CPT-based liquefaction resistance relationship was proposed by considering the effects of drainage conditions.
Combination Treatment with Histone Deacetylase and Carbonic Anhydrase 9 Inhibitors Shows Therapeutic Potential in Experimental Diffuse Intrinsic Pontine Glioma
Authors: Fujita Naohide , Bondoc Andrew , Ishida Joji , Taccone Michael S. , Riemenshneider Alexandra , Luck Amanda , Srikant Dilakshan , Siddaway Robert , Kondo Akihide , Arai Hajime , Smith Christian , McDonald Paul , Hawkins Cynthia , Dedhar Shoukat , Rutka James 
Published: March 2022

Abstract
Purpose: Despite extensive research, an effective and safe treatment for diffuse intrinsic pontine glioma (DIPG) has not been established. In this study, we investigate the therapeutic potential of combination therapy with histone deacetylase (HDAC) and carbonic anhydrase 9 (CA9) inhibitors against DIPG.Methods: We used RNA sequencing data from DIPG patient samples to evaluate the expression of the carbonic anhydrase family and the activity of the hypoxia signaling pathway. Next, we performed a synergy screen using CA9 inhibitor SLC-0111 and the HDAC inhibitors panobinostat, vorinostat, entinostat, and pyroxamide. We selected the SLC-0111/HDACi combination showing the highest synergy, and its effects on cell proliferation, invasion, and migration were evaluated. We also measured changes in histone acetylation, apoptosis, cell cycle, and intracellular pH.Results: CA9 was significantly upregulated in human DIPG samples. Furthermore, pathways downstream of CA9 were found to be activated when compared to normal brain tissue. The synergy screen revealed that the combination of SLC-0111 and pyroxamide was most effective at inhibiting DIPG cell proliferation. Furthermore, this combination reduced cell migration and invasion potential while enhancing histone acetylation with subsequent reduction of cell population in S Phase. Finally, the SLC-0111 and pyroxamide combination showed greater reduction of intracellular pH as compared to each agent alone.Conclusion: Our in vitro data suggest that the combination of SLC-0111 and pyroxamide shows promise in the treatment of experimental DIPG. Based on these findings, further investigation of this combination therapy in preclinical models is warranted.
Paneth cell maturation is related to epigenetic modification during neonatal–weaning transition
Authors: Baba Ryoko , Kokubu Keiji , Nakamura Kenta , Fujita Mamoru , Morimoto Hiroyuki 
Published: March 2022

Abstract
Paneth cells are antimicrobial peptide-secreting epithelial cells located at the bottom of the intestinal crypts of Lieberkühn. Crypts begin to form around day 7 of postnatal mice (P7), and Paneth cells usually appear within the first 2 weeks. Paneth cell dysfunction has been reported to correlate with Crohn’s disease-like inflammation, showing narrow crypts or loss of crypt architecture in mice. The morphology of dysfunctional Paneth cells is similar to that of a Paneth/goblet intermediate cell. However, it remains unclear whether the formation of the crypt is related to the maturation of Paneth cells. In this study, we investigated the histological changes in the mouse ileum postnatally and assessed the effect of the methyltransferase inhibitor on epithelium development using organoid culture. The morphological and functional maturation of Paneth cells occurred in the first 2 weeks and was accompanied by histone H3 lysine 27 (H3K27) trimethylation. Inhibition of H3K27 trimethylation suppressed crypt formation and Paneth cell maturation on organoids derived from ileum of early second postnatal mouse. Overall, our data show that post-transcriptional modification of histones, particularly H3K27 trimethylation, leads to the structural and functional maturation of Paneth cells during postnatal development.
Private car or public transport? - what effects does the service accessibility have on public transport utilisation in the City of London
Authors: J Aleksandra 
Published: March 2022

Abstract
In recent years there have been an increased drive globally to reduce private car journeys and increase the public transport use, cycling or walking. To support the shift in behavioural change and enable transition to more sustainable transport choices, many researches have been carried out to identify factors that may influence commuters’ decisions in relation to their transport mode selection. Number of those have shown that good quality public transport services can lead to its improved attractiveness. This study examines public transport accessibility levels across the City of London and its effects on the public transport utilisation and car ownership in the city.
One-pot synthesis of Au-M@SiO2 (M = Rh, Pd, Ir, Pt) core-shell nanoparticles as highly efficient catalysts for the reduction of 4-nitrophenol
Authors: Hao Junfang , Liu Bin , Maenosono Shinya , Yang Jianhui 
Published: March 2022

Abstract
The conversion of p-nitrophenol (4-NP) to p-aminophenol (4-AP) is of great significance for pharmaceutical and material manufacturing. In this work, Au-M@SiO2 (M = Rh, Pd, Ir, Pt) nanoparticles (NPs) with core-shell structures, which are expected to be excellent catalysts for the transformation of 4-NP to 4-AP, were synthesized by a facile one-pot one-step method. The structure and composition of the NPs were characterized through transmission electron microscopy (TEM), X-ray powder diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). Au-M@SiO2 (M = Rh, Pd, Ir, Pt) core-shell NPs showed excellent catalytic activity in the reduction of 4-NP, which is superior to most catalysts reported in the previous literature. The enhanced catalytic activity of Au-M@SiO2 core-shell NPs is presumably related to the bimetallic synergistic effect. This study provides a simple strategy to synthesize core-shell bimetallic NPs for catalytic applications.
Cognitive Functional Therapy (CFT) compared with a combined Core Training Exercise and Manual Therapy in patients with non-specific chronic low back pain: a study protocol for a randomized controlled trial
Authors: Castro Julia , Donato Bruno de Sousa , Arruda Bruno , Pellegrini Marina Jacobucci , de Souza Cíntia Pereira , Fernandez Jessica , Reis Felipe José Jandre , Correa Luis Claudio Lemos , Meziat-Filho Ney 
Published: March 2022

Abstract
Background: Chronic non-specific low back pain (CNSLBP) is a public health issue associated with a complex interaction of biopsychosocial factors. Cognitive Functional Therapy is a multidimensional approach for CNSLBP which targets negative cognitions and maladaptive functional behaviors (via body relaxation, control and extinction of protective and safety behaviors). Since the evidence about the efficacy of CFT is still limited, it is important to perform clinical trials with the aim of comparing CFT with other interventions commonly used in clinical practice of physiotherapy. The current study will investigate the efficacy of Cognitive Functional Therapy (CFT) compared to combined Core Training exercise and manual therapy (CORE-MT) on pain and disability in patients with CNSLBP. Methods: Two-group, randomized controlled trial with blinded assessors. We will recruit 148 patients with CNSLBP in a private clinic in the city of Campinas, Brazil. The experimental group will receive five one-hour individualized sessions of CFT within a period of two months. The control group will receive five one-hour individualized sessions of CORE-MT within a period of two months. Patients will be assessed pre-intervention, post-intervention and after six and twelve months. The primary outcomes will be pain intensity and disability two months after first intervention session; secondary outcomes will be pain intensity and disability at six and twelve months, as well as global perceived effect and patient satisfaction at two, six and twelve months after the first intervention session. Non-specific predictors, moderators and mediators of outcomes will also be analyzed. Discussion: The result of a high-quality randomized controlled clinical trial involving CFT will assist physiotherapists in the clinical decision-making process. The present study will have a sample size capable of detecting relevant clinical effects of treatment with a low risk of bias. Trial registration: The protocol has been written according to the SPIRIT statement to enhance transparency of content and completeness, has been approved by the Augusto Motta University Center Ethics Committee (research protocol number 2.219.742) and the findings of the trial will be reported following the CONSORT statement and the TIDieR checklist. Trial registration number: NCT03273114
Plasmon-induced flexibility and refractive index measurement in a sensor designed by a cavity, two rings, two teeth and two plasmonic waveguides.
Authors: HamidAbbasi  
Published: March 2022

Abstract
In this research, we design a plasmonic refractive index sensor and examine it numerically, using transparency, refractive index, sensitivity, FOM fit shape and Q quality factor, to optimize and improve performance quality. We will be. To design the structure of this sensor, we use two plasmonic waveguides, a cavity, two rings and two teeth. The resonant wavelengths and refractive index of the resonators are investigated and simulated by the finite difference time domain (FDTD) method, and we draw the obtained diagrams using MATLAB software. After completing the sensor design, due to the fact that the amplifiers are very sensitive to changes in the refractive index, so by changing the refractive index and changing the dimensions of the structure, we can weaken or strengthen the passage coefficient in the resonant modes. These plasmonic sensors with a simple frame and high optical resolution can be used to measure refractive index in the medical, chemical and food industries.
The crystal structure and chemistry of natural giniite and implications for Mars
Authors: Adcock Christopher T. , Hausrath Elisabeth M. , Rampe Elizabeth B. , Yang Hexiong , Downs Robert T. 
Published: March 2022

AbstractInvestigations of planetary processes using phosphate minerals often focus on igneous, recrystallized, or potentially metasomatized minerals, likely as a result of the minerals commonly available for study within meteorites and lunar samples. However, Mars is a relatively phosphorus-rich planet and possesses abundant evidence of past aqueous surface interactions. Therefore, secondary phosphate phases may be important on the martian surface. Giniite [Fe2+Fe43+(PO4)4(OH)2·2H2O] is a secondary phosphate mineral that has been suggested as a potentially significant phase at locations in Gusev Crater and Meridiani Planum on Mars. Although relatively rare as a natural mineral on Earth, giniite has gained attention as an important mineral in industry and technology, especially the lithium battery industry, and the ferrian version of the mineral is often synthesized. This suggests giniite may be important as an in situ resource utilization (ISRU) target for future extended human missions to Mars. Despite this, there are few data available on the natural mineral and the last characterization of the structure was over 40 years ago. There has also been confusion in the literature as to whether giniite is orthorhombic or monoclinic. In this work we revisit and document the chemistry and crystal structure of natural giniite from the type locality at the Sandamab pegmatite in Namibia using updated techniques. Our results refine and update what was previously known regarding the structure and chemistry of giniite and support the potential of the mineral as a possible martian scientific and resource target for further study to aid future missions.
Factors Affecting Early Intrauterine Device Expulsion Inserted Immediately
After Voluntary Termination of Pregnancy
Authors: Aksan Alperen , Dilbaz Berna , Dilbaz Serdar , Özdemir Ece 
Published: March 2022

Background:
Post-abortion insertion of an intrauterine device (IUD) is recommended for
the prevention of repetitive voluntary termination of pregnancy (VTOP) in women who choose to
have a reliable contraceptive method.

Aim:
This study aimed to analyze the incidence of IUD dislocation and its factors in patients who
had an IUD immediately inserted after VTOP.

Methods:
In this retrospective study, 288 consequent patients who came to our hospital for VTOP
between August 1st, 2018 to August 26th, 2019, and had given signed consent for immediate IUD insertion
were taken as the study group. The demographic characteristics, obstetric history, and gestational
age at the time of the procedure were obtained from the patient records. On the 10th day of
post-abortion, the localization of the IUD was evaluated by speculum examination and transvaginal
ultrasonography. The effects of obstetric history and gestational age at the time of termination on
IUD dislocation rates were analyzed statistically.

Results:
The overall incidence of IUD dislocation was 16.3 % at the 10th-day follow-up visit. The
incidence of IUD dislocation was similar in patients with gestational age < 5w, 5-7w, and 7-10w (21
%, 14.5 %, and 13 %, respectively, p=0.36). However, the incidence increased with high gravity and
parity. The gravity, parity, number of vaginal deliveries, and cesarean section were higher in patients
with an IUD dislocation than the ones with an IUD in place.

Conclusion:
The IUD insertion after voluntary legal termination of pregnancy is suitable for all gestational
ages. A high number of previous pregnancies and deliveries are risk factors for IUD expulsion
after immediate IUD insertion.
Leigh Gilmore and Elizabeth Marshall, Witnessing Girlhood. Toward an Intersectional Tradition of Life Writing
Authors: Davis Kathy 
Published: March 2022

This compact and elegantly composed volume brings together and analyses autobiographical narratives of girlhood in which adult women return to their own childhood and write about experiences of suffering, trauma, violence and abuse. These narratives range from slave narratives from the mid-nineteenth century, to comic books from the twenty-first century. While most of them are situated in the US context, several memoirs from other parts of the world are included, most notably, the testimonio of a Latin American indigenous woman, Rigoberta Menchú, a memoir in comic form of a young girl growing up in post-revolution Iran (Persepolis), and a children’s picture book My Hiroshima about the author’s relationship to the horrors of the atomic bombing on Hiroshima by the US in 1945. Other texts included are survivor memoirs on sexual violence (Girl, Interrupted by Susanna Kaysen), on debilitating illness (Autobiography of a Face by Lucy Grealy), and the comedian Hannah Gadsby’s stand-up performance about abuse and homophobia (Nanette). What these diverse narratives have in common is the desire to represent the child as witness without resorting to sentimental ideas about childhood innocence. The child is not only treated as a witness whose account needs to be taken seriously, but she also often emerges as an activist who calls on her audience to take an ethical stance against sexual violence, exploitation, or war.
Economic burden of lives lost due to COVID-19 in California State
Authors: Zheng Michelle , Lui Briana , Komlan Axell-Giovanni A , Bonaparte Christina R , White Robert S , Hoyler Marguerite M 
Published: March 2022

Aim:
To examine the economic impact of lives lost due to the coronavirus pandemic across California and Los Angeles (LA) County.
Patients & methods:
Years of potential life lost (YPLL) and the value of statistical life (VSL) were calculated using mortality data from the California Department of Public Health, the LA County Department of Public Health and the Social Security Administration websites.
Results:
In California and LA County, the average YPLL per person were 14.3 and 14.7 and the VSLs were approximately US$219.9 billion and $82.7 billion, respectively. YPLL and VSL were greatest for Latinos aged 50–64.
Conclusion:
The economic burden of lives lost due to the coronavirus across California and LA County is substantial. Latinos aged 50–64 were most affected.