bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nomogram Predicts the Role of Primary Tumor Surgery on De Novo Stage-IV Breast Cancer Patients: A SEER-Based Competing Risk Analysis Model
Authors: Cui Hanxiao , Dai Luyao , Bao Yuanhang , Hu Liqun , Zhou Zhangjian , Wang Meng , Lin Shuai , Wu Hao , Ma Xiaobin , Kang Huafeng 
Published: May 2022

ObjectiveThe efficacy of primary tumor surgery on survival in female patients with de novo stage IV breast cancer (BC) remains unclear. Our study endeavored to develop comprehensive competing risk nomograms to predict clinical outcomes and guide precision treatment in these patients.Participants and MethodsA total of 12281 patients who had distant metastasis at initial BC diagnosis between 2010 and 2017 in the Surveillance Epidemiology and End Results (SEER) database, were enrolled in this study. First, we assessed the impacts of primary tumor surgery on overall survival (OS) and breast cancer-specific survival (BCSS) using the Kaplan-Meier curves. Then subgroup analyses stratified by different metastatic patterns were performed using Cox and competing risk models (CRM). Based on the filtered independent prognostic parameters by CRM, we established two nomograms to predict the probability of breast cancer-specific death (BCSD) at 1-,2- and 3-year intervals. Furthermore, calibration curves and area under the curves (AUC) were conducted for validation.ResultsKaplan-Meier analysis revealed that surgery was associated with better OS and BCSS (P&lt;0.001). Subgroup analyses demonstrated that in bone-only metastases pattern, relative to breast-conserving surgery (BCS), patients receiving mastectomy had worse prognosis and the poorest survival belonged to non-surgery individuals (BCSS: mastectomy: HR=1.35; 95%CI=1.15-1.60; non-surgery: 2.42; 2.08-2.82; OS: mastectomy: 1.44; 1.23-1.68; non-surgery: 2.40; 2.08-2.78). Additionally, no survival difference was observed between BCS and reconstruction recipients (BCSS: HR=1.10; 95%CI=0.85-1.43; OS: 1.11; 0.86-1.44). Furthermore, patients undergoing BCS possessed similar BCSS with mastectomy recipients as well as reconstruction recipients in viscera metastases pattern, whereas non-surgery individuals had a worse survival (mastectomy: HR=1.04; 95%CI=0.92-1.18; reconstruction: 0.86; 0.69-1.06; non-surgery: 1.83; 1.63-2.05). Two competing risk nomograms of distinct metastatic patterns were established to comprehensively predict the survival of patients. Calibration curves indicated the terrific consistency of the models. Moreover, the AUC values in the training and validation sets were in the range of 0.70–0.80, exhibiting good specificity and sensitivity.ConclusionThe surgery implementation was associated with a lower probability of BCSD in de novo stage-IV BC patients. Our nomograms could offer a relatively accurate and individualized prediction of the cumulative incidence rate of BCSD after primary tumor resection.
Deep Learning Model for Classifying Metastatic Epidural Spinal Cord Compression on MRI
Authors: Hallinan James Thomas Patrick Decourcy , Zhu Lei , Zhang Wenqiao , Lim Desmond Shi Wei , Baskar Sangeetha , Low Xi Zhen , Yeong Kuan Yuen , Teo Ee Chin , Kumarakulasinghe Nesaretnam Barr , Yap Qai Ven , Chan Yiong Huak , Lin Shuxun , Tan Jiong Hao , Kumar Naresh , Vellayappan Balamurugan A. , Ooi Beng Chin , Quek Swee Tian , Makmur Andrew 
Published: May 2022

BackgroundMetastatic epidural spinal cord compression (MESCC) is a devastating complication of advanced cancer. A deep learning (DL) model for automated MESCC classification on MRI could aid earlier diagnosis and referral.PurposeTo develop a DL model for automated classification of MESCC on MRI.Materials and MethodsPatients with known MESCC diagnosed on MRI between September 2007 and September 2017 were eligible. MRI studies with instrumentation, suboptimal image quality, and non-thoracic regions were excluded. Axial T2-weighted images were utilized. The internal dataset split was 82% and 18% for training/validation and test sets, respectively. External testing was also performed. Internal training/validation data were labeled using the Bilsky MESCC classification by a musculoskeletal radiologist (10-year experience) and a neuroradiologist (5-year experience). These labels were used to train a DL model utilizing a prototypical convolutional neural network. Internal and external test sets were labeled by the musculoskeletal radiologist as the reference standard. For assessment of DL model performance and interobserver variability, test sets were labeled independently by the neuroradiologist (5-year experience), a spine surgeon (5-year experience), and a radiation oncologist (11-year experience). Inter-rater agreement (Gwet’s kappa) and sensitivity/specificity were calculated.ResultsOverall, 215 MRI spine studies were analyzed [164 patients, mean age = 62 ± 12(SD)] with 177 (82%) for training/validation and 38 (18%) for internal testing. For internal testing, the DL model and specialists all showed almost perfect agreement (kappas = 0.92–0.98, p &lt; 0.001) for dichotomous Bilsky classification (low versus high grade) compared to the reference standard. Similar performance was seen for external testing on a set of 32 MRI spines with the DL model and specialists all showing almost perfect agreement (kappas = 0.94–0.95, p &lt; 0.001) compared to the reference standard.ConclusionA DL model showed comparable agreement to a subspecialist radiologist and clinical specialists for the classification of malignant epidural spinal cord compression and could optimize earlier diagnosis and surgical referral.
Osteoarticular Infections in Pediatric Hospitals in Europe: A Prospective Cohort Study From the EUCLIDS Consortium
Authors: Trobisch Andreas , Schweintzger Nina A. , Kohlfürst Daniela S. , Sagmeister Manfred G. , Sperl Matthias , Grisold Andrea J. , Feierl Gebhard , Herberg Jethro A. , Carrol Enitan D. , Paulus Stephane C. , Emonts Marieke , van der Flier Michiel , de Groot Ronald , Cebey-López Miriam , Rivero-Calle Irene , Boeddha Navin P. , Agapow Paul-Michael , Secka Fatou , Anderson Suzanne T. , Behrends Uta , Wintergerst Uwe , Reiter Karl , Martinon-Torres Federico , Levin Michael , Zenz Werner ,   The EUCLIDS consortium
Published: May 2022

BackgroundPediatric osteoarticular infections (POAIs) are serious diseases requiring early diagnosis and treatment.MethodsIn this prospective multicenter cohort study, children with POAIs were selected from the European Union Childhood Life-threatening Infectious Diseases Study (EUCLIDS) database to analyze their demographic, clinical, and microbiological data.ResultsA cohort of 380 patients with POAIs, 203 with osteomyelitis (OM), 158 with septic arthritis (SA), and 19 with both OM and SA, was analyzed. Thirty-five patients were admitted to the Pediatric Intensive Care Unit; out of these, six suffered from shock, one needed an amputation of the right foot and of four left toes, and two had skin transplantation. According to the Pediatric Overall Performance Score, 36 (10.5%) showed a mild overall disability, 3 (0.8%) a moderate, and 1 (0.2%) a severe overall disability at discharge. A causative organism was detected in 65% (247/380) of patients.Staphylococcus aureus(S. aureus) was identified in 57.1% (141/247) of microbiological confirmed cases, including 1 (0.7%) methicillin-resistantS. aureus(MRSA) and 6 (4.2%) Panton-Valentine leukocidin (PVL)-producingS. aureus, followed by Group AStreptococcus(18.2%) andKingella kingae(8.9%).K. kingaeand PVL production inS. aureuswere less frequently reported than expected from the literature.ConclusionPOAIs are associated with a substantial morbidity in European children, withS. aureusbeing the major detected pathogen. In one-third of patients, no causative organism is identified. Our observations show an urgent need for the development of a vaccine againstS. aureusand for the development of new microbiologic diagnostic guidelines for POAIs in European pediatric hospitals.
Investigation of the Uptake and Transport of Aspirin Eugenol Ester in the Caco-2 Cell Model
Authors: Tao Qi , Qin Zhe , Liu Xi-Wang , Zhang Zhen-Dong , Li Shi-Hong , Bai Li-Xia , Li Jian-Yong , Yang Ya-Jun 
Published: May 2022

Background: Aspirin eugenol ester (AEE) is a novel medicinal compound synthesized by esterification of aspirin with eugenol using the prodrug principle. AEE has the pharmacological activities of being anti-inflammatory, antipyretic, analgesic, anti-cardiovascular diseases, and anti-oxidative stress However, its oral bioavailability is poor, and its intestinal absorption and transport characteristics are still unknown.Objective: The purpose of this study was to investigate the uptake and transport mechanisms of AEE in Caco-2 cells.Methods: The effects of time, concentration, and temperature on the transport and uptake of AEE were studied.Results: The results showed that a higher concentration of salicylic acid (SA) was detected in the supernatant of cell lysates and cell culture medium, while AEE was not detected. Therefore, the content change of AEE was expressed as the content change of its metabolite SA. In the uptake experiment, when the factors of time, concentration, and temperature were examined, the uptake of SA reached the maximum level within 30 min, and there was concentration dependence. In addition, low temperature (4°C) could significantly reduce the uptake of SA in Caco-2 cells. In the transport experiment, under the consideration of time, concentration, and temperature, the transepithelial transport of SA from AP-BL and BL-AP sides was time-dependent. The amount of SA transported in Caco-2 cells increased with the increase of concentration, but the transmembrane transport rate had no correlation with the concentration. This phenomenon may be due to the saturation phenomenon of high concentration. The efflux ratio (ER) was less than 1, which indicated that their intestinal transport mechanism was passive transport. Moreover, the temperature had a significant effect on the transport of AEE.Conclusion: In summary, intestinal absorption of AEE through Caco-2 cell monolayers was related to passive transport. The uptake and transport of AEE were concentration-dependent, and temperature significantly affected their uptake and transport. The absorption and transport characteristics of AEE may contribute to the exploration of mechanisms of absorption and transport of chemosynthetic drugs in vitro.
Reliability and Validation of the Child Eating Behavior Questionnaire in 3- to 6-Year-Old Spanish Children
Authors: Jimeno-Martínez Andrea , Maneschy Ivie , Moreno Luis A. , Bueno-Lozano Gloria , De Miguel-Etayo Pilar , Flores-Rojas Katherine , Jurado-Castro Jose Manuel , de Lamas Carmela , Vázquez-Cobela Rocio , Martinez-Lacruz Raúl , Portoles Olga , Martínez J. Alfredo , Navas-Carretero Santiago , Schröder Helmut , Fitó Montserrat , Babio Nancy , Salas-Salvadó Jordi , Leis Rosaura , Gil-Campos Mercedes , Rupérez Azahara I. 
Published: May 2022

IntroductionEating behavior is often established during the first years of life. Therefore, it is important to make a research on it to understand the relationships that children have with food and how this can contribute to prevent the development of childhood obesity. An appropriate assessment of eating behavior can be achieved using the “Child Eating Behavior Questionnaire” (CEBQ). This questionnaire has been validated in several populations and languages, but it has never been translated, adapted, and validated for Spanish children.AimTo evaluate the reliability and internal consistency of the CEBQ questionnaire, culturally adapted and translated into Spanish (Spain), in Spanish families with children aged 3 to 6 years, as well as its association with children’s body mass index (BMI) to test its construct validity.Materials and MethodsChildren between 3 and 6 years old were recruited from the ongoing MELI-POP randomized controlled clinical trial, as well as from public schools located in middle class neighborhoods of Zaragoza, Spain, to complete the sample. Sociodemographic characteristics and anthropometric measures were obtained according to standardized methods. The 35-item CEBQ questionnaire was completed twice with a time difference of 3 weeks between each response. Statistical analyses included the evaluation of internal consistency and reliability of the questionnaire, a confirmatory factor analysis, and the association between the different CEBQ scales and the children’s BMI.ResultsA total of 197 children completed variables; 97 of them were boys (49.2%) and 100 girls (50.8%). Mean age of the total sample was 4.7 ± 0.9 years. There was a high test-re-test reliability of the questionnaire with values close to 1, with an average of 0.66 and a good internal consistency (Cronbach alpha with values above 0.7), so that a high reliability is established between the items in each scale. A gradual positive association was found between the score of different “pro-intake” scales of the CEBQ: “Food Responsiveness,” “Emotional Overeating,” and “Enjoyment of food” and the children’s BMI; at the opposite, negative associations were observed between BMI and the score of anti-intake scales “Satiety Responsiveness,” “Slowness in Eating,” and “Emotional Undereating.”ConclusionThe Spanish version of the CEBQ is a useful tool to assess the eating behavior of Spanish children because the high reliability and internal validity. There is a significant association between eating behavior and BMI in Spanish children.
Language Entropy Relates to Behavioral and Pupil Indices of Executive Control in Young Adult Bilinguals
Authors: van den Berg Floor , Brouwer Jelle , Tienkamp Thomas B. , Verhagen Josje , Keijzer Merel 
Published: May 2022

IntroductionIt has been proposed that bilinguals’ language use patterns are differentially associated with executive control. To further examine this, the present study relates the social diversity of bilingual language use to performance on a color-shape switching task (CSST) in a group of bilingual university students with diverse linguistic backgrounds. Crucially, this study used language entropy as a measure of bilinguals’ language use patterns. This continuous measure reflects a spectrum of language use in a variety of social contexts, ranging from compartmentalized use to fully integrated use.MethodsLanguage entropy for university and non-university contexts was calculated from questionnaire data on language use. Reaction times (RTs) were measured to calculate global RT and switching and mixing costs on the CSST, representing conflict monitoring, mental set shifting, and goal maintenance, respectively. In addition, this study innovatively recorded a potentially more sensitive measure of set shifting abilities, namely, pupil size during task performance.ResultsHigher university entropy was related to slower global RT. Neither university entropy nor non-university entropy were associated with switching costs as manifested in RTs. However, bilinguals with more compartmentalized language use in non-university contexts showed a larger difference in pupil dilation for switch trials in comparison with non-switch trials. Mixing costs in RTs were reduced for bilinguals with higher diversity of language use in non-university contexts. No such effects were found for university entropy.DiscussionThese results point to the social diversity of bilinguals’ language use as being associated with executive control, but the direction of the effects may depend on social context (university vs. non-university). Importantly, the results also suggest that some of these effects may only be detected by using more sensitive measures, such as pupil dilation. The paper discusses theoretical and practical implications regarding the language entropy measure and the cognitive effects of bilingual experiences more generally, as well as how methodological choices can advance our understanding of these effects.
Liver Transplantation for Hepatocellular Carcinoma With Bile Duct Tumor-Associated Thrombi: A Systematic Review and Pooled Analysis
Authors: Kim Steven C. , Bolognese Alexandra C. , Little Christopher J. , Hitchcock Mary E. , Leverson Glen E. , Al-Adra David P. 
Published: May 2022

IntroductionThe significance of bile duct tumor-associated thrombi in patients undergoing transplantation for hepatocellular carcinoma (HCC) is controversial. Therefore, we performed a systematic review of the literature with pooled analysis to investigate the impact of biliary invasion on HCC recurrence and patient survival.MethodsOf 1,584 references screened, eight were included for analysis. Demographics, patient and tumor factors, recurrence, and survival data were analyzed. Time to recurrence and death were extracted from each paper by cross-referencing survival curves.ResultsA total of 35 patients across eight studies were pooled for analysis when follow-up data were available. At 1 year, 92.9% of patients undergoing transplantation for HCC with bile duct thrombi were alive. Overall survival at 3 and 5 years was 65.5 and 49.6%, respectively. At 1 year, 21.6% of patients had recurrence of their disease, while at 3 years, 50.4% of patients had recurrence. Of those patients with recurrence in the first year, 71.4% recurred within the first 3 months after transplantation.ConclusionOverall patient survival decreased within the first 5 years, but then stabilized. The 5-year survival rate of 49.6% in this pooled analysis is lower than that reported for patients undergoing transplantation for HCC within the Milan criteria (50–78%) or recent reports in patients with portal vein involvement (63.6%), though data is limited by a lack of long-term follow-up in this understudied population. Transplantation for patients with HCC with bile duct involvement may be a viable treatment option, warranting further investigation.
Influence of Psychological Nursing Procedure on Negative Emotion, Stress State, Quality of Life and Nursing Satisfaction in Patients with Lung Cancer Radical Operation
Authors: Yu Yizhi , Xia You , Fan Xiaoyan , Chen Yong , Li Chengjuan , Zhang Jing 
Published: May 2022

ObjectiveTo discuss the influence of psychological nursing procedure on negative emotion, stress state, quality of life and nursing satisfaction in patients with lung cancer radical operation.Methods106 patients with lung cancer who underwent radical resection in our hospital from September 2019 to September 2021 were selected. According to the intervention time, patients were divided into Group A and Group B, with 53 cases in each group. Group A received routine nursing, Group B used psychological nursing procedure on the basis of Group A. The negative emotions, stress state, quality of life and nursing satisfaction of patient were observed.ResultsSelf-rating anxiety scale and self-rating depression scale scores of Group B were lower than Group A (P &lt; 0.05). The levels of norepinephrine, epinephrine and cortisol in Group B were lower than Group A (P &lt; 0.05). Generic quality of life inventory-74 scores of Group B were higher than Group A (P &lt; 0.05). The nursing satisfaction of Group B (88.68%) was higher than Group A (73.58%) (P &lt; 0.05).ConclusionPsychological nursing procedure is conducive to reducing the negative emotion, relieving stress reaction, improving the quality of life, increasing nursing satisfaction of patients with lung cancer radical operation.
Associations of COVID-19-Related Health, Healthcare and Economic Factors With Prenatal Depression and Anxiety
Authors: Avalos Lyndsay A. , Nance Nerissa , Badon Sylvia E. , Young-Wolff Kelly , Ames Jennifer , Zhu Yeyi , Hedderson Monique M. , Ferrara Assiamira , Zerbo Ousseny , Greenberg Mara , Croen Lisa A. 
Published: May 2022

Objective: This study evaluated whether COVID-19 pandemic-related health, healthcare and economic factors during pregnancy are associated with prenatal depression and anxiety.Methods: We conducted a cross-sectional study of 6,628 pregnant members of Kaiser Permanente Northern California who responded to a survey between 22 June and 30 September 2020. The survey included questions about depression (Patient Health Questionnaire) and anxiety (Generalized Anxiety Disorder) symptoms and COVID-19-related health and healthcare (e.g., had COVID-19) and economic (e.g., food insecurity) factors.Results: Over one third of individuals reported depression (25% mild, 8% moderate, 3% severe) or anxiety (22% mild, 8% moderate, 5% severe) symptoms. In multivariable analyses, COVID-19 during pregnancy, employment with greater risk of COVID-19, distress over changes in prenatal care, job loss, changes in childcare and food insecurity were associated with greater odds of prenatal depression or anxiety.Conclusion: Findings suggest the COVID-19 pandemic may have severe mental health repercussions for pregnant individuals. Support services for pregnant individuals experiencing these COVID-19-related factors and monitoring of those who had moderate/severe prenatal depression and anxiety symptoms during the COVID-19 pandemic is warranted.
Perilaku Masyarakat Bantaran Sungai Percut Dalam Aktivitas Membuang Sampah Rumah Tangga Di Desa Percut Kecamatan Percut Sei Tuan
Authors: Sridaryanti Wahyu Novi , Pinem Mbina 
Published: May 2022

Penelitian ini bertujuan untuk:(1) mengetahui karakteristik masyarakat bantaran sungai Percut, (2)mengetahui sikap dan tindakan masyarakat bantaran sungai Percut terhadap aktivitas membuang sampah rumah tangga ke sungai, dan(3) pengaruh karakteristik masyarakat terhadap perilaku masyarakat membuang sampah rumah tangga. Penelitian ini dilaksanakan di Desa Percut Kecamatan Percut Sei Tuan Kabupaten Deli Serdang tahun 2020. Populasi penelitian ini adalah seluruh masyarakat yang tinggal dibantaran sungai Percut berjarak 100meter dari sungai yaitu 120 KK.yang sekaligus dijadikan sebagai sampel. Tehnik pengambil data dilakukan dengan komunikasi langsung (wawancara).dan data dianalisis dengan regresi sederhana. Hasil penelitan menunjukan bahwa: 1)Karakteristik responden menurut umur mayoritas responden adalah usia produktip dan pendidikan responden umumnya adalah pendidikan rendah (SMP) yakitu 35%. Responden pada umumnya berpendapatan < Rp 2.499.423 berjumlah 97 responden. 2) Sikap membuang sampah rumah tangga masyarakat bantaran Sungai Percut secara umum adalah kategori sikap kurang yaitu 50,8 %. Sedangkan tindakan masyarakat pada umumnya masuk dalam kategori tindakan kurang dalam membuang sampah rumah tangga adalah 41,6 %. 3) hasil uji-t diperoleh nilai thitung> ttabel (2,483 > 1,980) serta nilai sig < 0,05 = 0,004 < 0,05. Bahwa hal ini hubungan antara karakteristik masyarakat bantaran sungai Percut dengan perilaku masyarakat dalam aktivitas pembuangan sampah rumah tangga.
Efektifitas Kebijakan Operasi Ketupat Semeru 2021 dalam Mengendalikan Penularan Covid-19 di Kabupaten Sidoarjo
Authors: Sopah Fidianing , Arif Lukman 
Published: May 2022

This article aims to analyze the effectiveness of the 2021 Ketupat Semeru Operational Policy in the of Covid-19. The problem is focused on the results of the policy operation that has been carried out by the Indonesian National Police with the code "Ketupat Jaya 2021" in Sidoarjo Regency, it is found that there is still a spike in psitive cases of Covid-19. To approach this problem, Sutrisno's 2017 effectiveness theory reference is used with five focuses, namely understanding the program, being on target, being on time, achieving goals, and real change. The data were collected through interviews, observation, documentation and others, and analyzed descriptively qualitatively. This study concludes that the 2021 Ketupat Semeru Operational Policy in Sidoarjo Regency is considered not yet effective in dealing with Covid-19 transmission.