bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Validation of a UHPLC–MS/MS Method for Quantitation of Almonertinib in Rat Plasma: Application to an in vivo Interaction Study Between Paxlovid and Almonertinib
Authors: Tang Peng-fei , Bao Su-su , Gao Nan-yong , Shao Chuan-feng , Xie Wei-fei , Wu Xue-meng , Zhao Le-ping , Xiao Zhong-xiang 
Published: July 2022

Almonertinib was approved for the first-line treatment of advanced NSCLC patients with EGFR-TKI-sensitive genetic mutations by National Medical Products Administration (NMPA) in 2021.The purpose of this study was to establish and validate a fast, accurate, stable and facile ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of almonertinib in rat plasma, it was employed to explore the effect of Paxlovid on the pharmacokinetics of almonertinib in rats. Zanubrutinib was used as an internal standard (IS), and the plasma samples were prepared by the protein precipitation method using acetonitrile. Chromatographic separation was carried out on a Shimadzu LC-20AT ultra-performance liquid chromatography system using a Shim-pack velox C18 (2.1× 50 mm, 2.7 μM) column. The mobile phase consisted of methanol and 0.1% formic acid-water. Mass spectrum analysis was executed using Shimadzu 8040 Triple quadrupole mass spectrometry. The precursor and product ions of the analyte and internal standard were detected in multiple reaction monitoring (MRM) mode. The typical fragment ions were m/z 526.20 → 72.10 for almonertinib and m/z 472.15 → 290.00 for zanubrutinib (IS). The method was validated to have good linearity for quantifying almonertinib in rat plasma from 0.1–1000 ng/ml (R2 = 0.999), and the LLOQ was 0.1 ng/ml. The validity of this method was sufficiently verified for selectivity, specificity, extraction recovery, matrix effect, accuracy, precision and stability. The validated UHPLC–MS/MS method was successfully applied to the drug interaction study of almonertinib with Paxlovid in rats. Paxlovid significantly inhibits the metabolism of almonertinib and increased the exposure of almonertinib. This study can help us to understand the metabolic profile of almonertinib better, and further human trials should be conducted to validate the results.
Impact of the Addition of a Centrifugal Pump in a Preterm Miniature Pig Model of the Artificial Placenta
Authors: Charest-Pekeski Alex J. , Cho Steven K. S. , Aujla Tanroop , Sun Liqun , Floh Alejandro A. , McVey Mark J. , Sheta Ayman , Estrada Marvin , Crawford-Lean Lynn , Foreman Celeste , Mroczek Dariusz , Belik Jaques , Saini Brahmdeep S. , Lim Jessie Mei , Moir Olivia J. , Lee Fu-Tsuen , Quinn Megan , Darby Jack R. T. , Seed Mike , Morrison Janna L. , Haller Christoph 
Published: July 2022

The recent demonstration of normal development of preterm sheep in an artificial extrauterine environment has renewed interest in artificial placenta (AP) systems as a potential treatment strategy for extremely preterm human infants. However, the feasibility of translating this technology to the human preterm infant remains unknown. Here we report the support of 13 preterm fetal pigs delivered at 102 ± 4 days (d) gestation, weighing 616 ± 139 g with a circuit consisting of an oxygenator and a centrifugal pump, comparing these results with our previously reported pumpless circuit (n = 12; 98 ± 4 days; 743 ± 350 g). The umbilical vessels were cannulated, and fetuses were supported for 46.4 ± 46.8 h using the pumped AP versus 11 ± 13 h on the pumpless AP circuit. Upon initiation of AP support on the pumped system, we observed supraphysiologic circuit flows, tachycardia, and hypertension, while animals maintained on a pumpless AP circuit exhibited subphysiologic flows. On the pumped AP circuit, there was a progressive decline in umbilical vein (UV) flow and oxygen delivery. We conclude that the addition of a centrifugal pump to the AP circuit improves survival of preterm pigs by augmenting UV flow through the reduction of right ventricular afterload. However, we continued to observe the development of heart failure within a matter of days.
Post-Hatch Performance of Broilers Following Hypoxic Exposure During Incubation Under Suboptimal Environmental Temperature
Authors: Haron A. , Shinder D. , Ruzal M. , Druyan S. 
Published: July 2022

The modern broiler is selected to exploit its full genetic potential, to sustain a rapid growth rate, and to lower the feed conversion rate (FCR). Recently reported reductions in FCR have been associated with augmented tissue formation at the expense of physiological functions such as thermoregulation. In turn, modern broilers exhibit a relatively low capability to balance energy expenditure under suboptimal ambient temperature. Hypoxic conditions at late incubation stages play a role in reforming metabolic plasticity. This work examined the effect of exposure to 12-h hypoxia (12H; 17% O2) for three consecutive days (from E16 through E18), or continuous hypoxia exposure for 48 h (48H), from E16 through E17, as compared to standard incubation (21% O2) on post-hatch performance of broilers maintained under suboptimal ambient temperatures (cold, hot, and diurnal cyclic ambient temperature). 12H chicks kept under hot ambient temperature had significantly lower body temperature (Tb) as compared to the control chicks. On day 42, both 12H and 48H chicks grown in the cyclic temperature room had significantly lower Tbs than controls. In parallel, from week 4, onward, 12H chicks had a significantly lower FCR than controls, and the 48H chicks demonstrated a lower FCR from week 5 and on. 12H and 48H broilers maintained under diurnal cyclic ambient temperature, exhibited significantly greater relative breast muscle weight, and a similar pattern was found in hypoxic broilers raised under standard and hot ambient temperatures. Hypoxic manipulation affects and create an adaptive bias in allocating metabolic energy between maintenance and growth, thus resulting in improved broiler performance, thermoregulation, and rearing under suboptimal environmental temperature.
“Your Ovaries Are Expired, Like an Old Lady” Metaphor Analysis of Saudi Arabian Women’s Descriptions of Breast Cancer: A Qualitative Study
Authors: Almegewly Wafa Hamad , Alsoraihi Maha Hamed 
Published: July 2022

BackgroundAssessing and understanding the language that women use to express physical, emotional, and social concerns of breast cancer experiences can often be overlooked, even though there is evidence that effective communication between cancer patients and health care providers improves quality of life. This study aims to assess the use of metaphors in conceptualizing breast cancer experience lived by Saudi Arabian women.Materials and MethodsThis is an interpretative phenomenological qualitative study, a purposeful sample of 18 breast cancer patients at an oncology outpatient’s clinic in Saudi Arabia were invited to engage in face-to-face interviews. Data was analyzed using Metaphor Identification Procedure (MIP).ResultsFour themes were constructed: dark hidden force, battling imminent death, dreaming and awakening calls, and inner and outer transformation.ConclusionIdentifying metaphors may be beneficial toward improving communication between health care providers and breast cancer patients, who often experience difficulties expressing their needs.
Patterns of adverse childhood experiences and depressive symptom trajectories in young adults: A longitudinal study of college students in China
Authors: Li Shuqin , Wang Rui , Thomas Erica , Jiang Zhicheng , Jin Zhengge , Li Ruoyu , Qian Yan , Song Xianbing , Sun Ying , Zhang Shichen , Chen Ruoling , Wan Yuhui 
Published: July 2022

BackgroundAdverse childhood experiences (ACEs) tend to cluster together in daily life, and most studies focus on the level of depression at certain points, but the dynamic process of depression is often neglected. Thus, research is urgently needed to explore the relationship between ACEs pattern and trajectory of depressive symptom levels at multiple time points in order to provides early targeted interventions to those who are most at risk.ObjectiveWe aimed to explore patterns of ACEs, including types and timing, associated with depression trajectories in college students.MethodsA school-based health survey was used to collect data as part of a longitudinal study in two medical college in Anhui province, China. Questionnaires were issued to 3,662 participants aged 17–22 and recorded details of ACEs (types and timing) and depression. Latent class analysis (LCA) was used to identify “patterns” of ACEs type and timing. Depressive symptom trajectories employed latent class growth analysis (LCGA). Multiple logistic regressions were employed to evaluate the relationships between ACEs patterns and depressive symptom trajectories.ResultsWe identified five ACEs patterns: “High neglect/emotional abuse/community violence,” “High neglect/emotional abuse,” “High neglect/family dysfunction,” “High neglect,” “Low ACEs.” We traced three depression trajectories: “High depressive symptom” “Moderate depressive symptom,” “Low depressive symptom.” “High neglect/emotional abuse/community violence,” “High neglect/emotional abuse” and “High neglect/family dysfunction” demonstrated a high risk for “High depressive symptom” and “Moderate depressive symptom.” “High neglect” showed a high risk for “Moderate depressive symptom” but not for “High depressive symptom” (P &lt; 0.05).ConclusionsThe findings address the need for a comprehensive consideration of exposure to childhood adversity associated with the risk of depression in young adults through identifying more problematic ACEs patterns amongst exposed children.
Translating and Evaluating a Physical Activity Program for Aboriginal Elders on Noongar Boodjar (Country) — A Longitudinal Study
Authors: Gidgup Margaret J. R. , Kickett Marion , Jacques Angela , Weselman Tammy , Hill Keith D. , Coombes Julieann , Ivers Rebecca , Bowser Nicole , Palacios Vilma , Hill Anne-Marie 
Published: July 2022

ObjectiveThe primary aim of the study was to translate and evaluate the impact of a Physical Activity (PA) program on the physical function of older Aboriginal Elders on Noongar Boodjar (Country).MethodsA longitudinal design framed within an Indigenous methodology. Two groups, one metropolitan and one regional, of Aboriginal Elders, aged ≥45 years, participated in the Ironbark PA program. This comprised weekly strength and balance exercises followed by yarning circles. Physical function (primary outcome) and functional ability, cardiovascular risk factors (weight, waist circumference), falls efficacy and health-related quality of life were measured at baseline 6, 12 and 24 months. Data were analyzed using generalized linear mixed effects modeling.ResultsFifty-two Elders initially enrolled and of those, n = 23 (44.2%) Elders participated regularly for 24 months. There was a 6-month gap in program delivery due to the COVID-19 pandemic. Participants made significant improvement in physical function at 12 months compared to baseline: [short physical performance battery (SPPB) at baseline, 8.85 points (95% CI 8.10, 9.61); 12 months 10.28 (95% CI 9.44, 11.13), p = 0.001: gait speed at baseline 0.81 ms−1 (95% CI 0.60, 0.93); 12 months 1.14 (95% CI 1.01, 1.27), p &lt; 0.001]. Some sustained improvement compared to baseline was still evident at 24 months after the 6-month gap in attendance [SPPB 9.60 (8.59, 10.60) p = 0.14, gait speed 1.11 (0.95, 1.26) p &lt; 0.001]. Cardiovascular risk factors showed a non-significant improvement at 12 and 24 months compared to baseline. All participants reported that they enjoyed the program, found it culturally appropriate and would recommend it to others.ConclusionOlder Aboriginal people showed sustained improvements in physical function after engaging in a culturally appropriate PA program. Culturally appropriate PA programs provide safety, security and choice for older Aboriginal people to engage in evidence-based PA.
Effectiveness of school-based child sexual abuse intervention among school children in the new millennium era: Systematic review and meta-analyses
Authors: Che Yusof Ruhana , Norhayati Mohd Noor , Mohd Azman Yacob 
Published: July 2022

IntroductionSchool-based child sexual abuse intervention programs were developed to educate the school children to protect them from sexual abuse. The programs were evaluated to make sure the interventions were effective in reducing child sexual abuse cases (CSA). This review aimed to determine the effectiveness of the school-based child sexual abuse intervention programs in the new millennium era (2000–2021) in improving the knowledge, skills, and attitude of school children under 18 years old toward child sexual abuse.MethodsA systematic search was conducted through MEDLINE (PubMed), EBSCO, and SCOPUS databases to collect full English articles related to school-based CSA intervention programs published from 2000 to 2021.ResultsA total of 29 studies from randomized control trial and quasi-experimental from several countries was analyzed. Comparisons within group of pre-post intervention for knowledge, skills, and attitude were measured by standardized mean difference (SMD) and 95% CI of −1.06 (95% CI: −1.29, −0.84), −0.91 (95% CI: −1.2, −0.61), and −0.51 (95% CI: −3.61, 0.58), respectively. Meanwhile for between intervention and control group comparisons, the SMD of knowledge was 0.9 (95% CI: 0.63, 1.18), skills was 0.39 (95% CI: 0.07, 0.71), and attitude was 1.76 (95% CI: 0.46, 3.07).ConclusionThe programs were found to be effective in improving the knowledge, skills, and attitude of the students from pre-intervention to post-intervention and between the intervention and control groups.Systematic Review Registration:www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022312383, identifier: CRD42022312383.
The impact of the COVID-19 pandemic on the prevalence and risk factors of workplace violence among healthcare workers in China
Authors: Qi Miao , Hu Xiuli , Liu Jun , Wen Jing , Hu Xue , Wang Zhizhong , Shi Xiuquan 
Published: July 2022

BackgroundThe pandemic of COVID-19 has significantly increased the burden on healthcare workers and potentially affect their risk of workplace violence (WPV). This study aimed to explore the prevalence and risk factors of WPV among healthcare workers during the peaking and the remission of the COVID-19 pandemic in China.MethodsUsing the snowball method, a repeated online questionnaire survey was conducted among Chinese healthcare workers from March 27th to April 26th in 2020 and 2021, respectively. Data included healthcare workers' socio-demographic and occupational characteristics, psychological status, and workplace violence.ResultsA total of 3006 samples in 2020 and 3465 samples in 2021 were analyzed. In 2020, the prevalence of WPV and witnessing colleagues suffering from WPV among healthcare workers were 64.2% and 79.7% respectively. Compared with 2020, the prevalence decreased by 11.0% and 14.4% in 2021, respectively. Logistic regression showed that WPV in 2020 was influenced by males, long working experience, working in the psychiatric department, direct contact with COVID-19 patients, self-discovery of medical errors, moral injury, depression, and anxiety (minimum OR = 1.22, maximum OR = 2.82). While risk factors of WPV in 2021 included males, working in psychiatric departments, self-discovery of medical errors, moral injury, depression, and anxiety (minimum OR = 1.33, maximum OR = 3.32); and protective factors were holding a master's degree (OR = 0.78) and working in other departments (OR = 0.54).ConclusionThis study retains the common effects of WPV among healthcare workers, though after the baptism of the COVID-19 pandemic, the prevalence of WPV among healthcare workers decreased; however, part of the influencing factors changed. In addition, COVID-19 has seriously affected the mental health of healthcare workers, and the effect of mental health problems on WPV should also attract more attention.
A novel prognostic model based on three clinic-related miRNAs for prostate cancer
Authors: Che Ping , Jiang Shihao , Zhang Weiyang , Zhu Huixuan , Hu Daorong , Wang Delin 
Published: July 2022

BackgroundProstate cancer (PCa) is the second most common malignant tumor in men worldwide. MiRNAs have been reported to play significant roles in prognosis prediction for patients with malignant tumors.MethodsThe survival-related miRNAs (sDMIRs) were identified by Cox regression analysis. A risk score model (RSM) was established based on three sDMIRs. The expression levels of sDMIRs in cell lines and clinical samples were detected via quantitative polymerase chain reaction. The correlations between sDMIRs and clinicopathological characteristics of PCa patients were evaluated using the chi-square test and Fisher's exact probability method.ResultsFour sDMIRs were remarkably related to the prognosis of PCa patients based on univariate Cox analysis, of which miR-10a-5p, miR-20a-5p, and miR-508-3p were used to establish the RSM. The OS in the low-risk group was better than that in the high-risk group. In the verification of various prostate cell lines and clinical samples from 162 PCa patients, the prominently higher expression of miR-10a-5p and miR-20a-5p and lower expression of miR-508-3p were detected in PCa cell lines and tumor tissues, especially the more advanced T-stage. Besides, the higher expression of miR-20a-5p and miR-10a-5p was significantly correlated to the higher level of PSA, Gleason score, more advanced T-stage, and distant metastasis status.ConclusionWe identify and validate the clinical significance of three sDMIRs and establish a verified RSM to evaluate the prognosis for PCa patients. The findings not only provide a reliable tool for clinical decision-makers to evaluate patients' prognosis but also offer a novel perspective into the field of biomarker identification.
Inteligencia social y convivencia escolar en una institución pública del Perú
Authors: VILLAVICENCIO FLORES JULIA MAXIMINA , BOCANEGRA MORALES MIRTHA Betty , CORDERO SARMIENTO Lisset Ketty , MORÁN ESPINO Cindy ELIZABETH 
Published: July 2022

La investigación se realizó en el distrito de Los Olivos, tuvo como objetivo general determinar la relación entre la inteligencia social y la convivencia escolar en los estudiantes del V ciclo de una institución educativa. El estudio se encuentra bajo el paradigma cuantitativo, método hipotético-deductivo, de diseño no experimental- transversal. La población estuvo conformada por 198 estudiantes y la muestra fue de 131. La técnica empleada para recolectar la información fue la encuesta y los instrumentos de recolección de datos fueron dos cuestionarios. Los resultados de la investigación dan una correlación de Rho de Spearman de ,978 entre la variable inteligencia social y la variable convivencia escolar, lo que indica que existe correlación fuerte entre las variables mencionadas y la significancia de p= ,000 es menor a ? = ,05 por lo cual se acepta la hipótesis del investigador. Concluyendo que existe una relación directa y significativa entre la variable: inteligencia social y los componentes de la variable: convivencia escolar.
Demotivasi Dalam ESP Classroom: Pembelajaran Bahasa Inggris Teologi Pada Perguruan Tinggi Agama Kristen
Authors: Palimbunga Theo Dedy 
Published: July 2022

Abstract: Generally, researches about motivation in learning English were more focused on the positive influences that encourage interest in language learning and efforts to maintain the interest. Whereas, there is also another side of motivation. This condition is a loss of motivation which is then referred as demotivation. In English for Theology classroom, there were some students who are not enthusiastic in the learning process. The learning objectives will not be achieved if the students are demotivated. Considering these problems, then, the purpose of this study was to explore the demotivation factors in learning English for Theology. The research was conducted using descriptive qualitative research methods. The data were collected through semi-structured interviews with 12 students as research’s informants.The results showed that there were two demotivation factors in learning English for Theology, namely external factors dan internal factors. External factors consist of learning environment and facilities, characteristics of English for Theology, teaching and learning methods and assessment of learning achievement. Internal factors consist of negative attitudes towards English for Theology and intelligence.

Keywords: Demotivation, ESP Classroom, English for Theology

Abstrak: Pada umumnya, fokus penelitian tentang motivasi pembelajaran bahasa Inggris lebih banyak membahas pengaruh-pengaruh positif yang mendorong minat belajar dan upaya untuk memelihara minat tersebut. Padahal, terdapat juga sisi lain motivasi yang dialami oleh setiap mahasiswa. Kondisi tersebut adalah kehilangan motivasi yang kemudian disebut sebagai demotivasi. Apabila demotivasi muncul dalam diri para mahasiswa maka tentunya akan menghambat proses belajar dan mengajar. Hal ini juga terjadi pada mahasiswa yang mempelajari Bahasa Inggris Teologi. Terdapat mahasiswa yang tidak bersemangat dalam proses pembelajaran. Jika hal seperti ini dibiarkan maka tentunya tujuan pembelajaran tidak akan tercapai. Melihat permasalahan tersebut maka tujuan penelitian ini adalah untuk mengetahui faktor-faktor demotivasi dalam pembelajaran Bahasa Inggris Teologi yang dialami oleh mahasiswa. Penelitian dilaksanakan dengan menggunakan metode deskriptif kualitatif. Data dikumpulkan melalui wawancara semi terstruktur dan melibatkan sebanyak 12 mahasiswa sebagai informan penelitian. Hasil penelitian menunjukkan bahwa terdapat dua faktor demotivasi pada pembelajaran Bahasa Inggris Teologi yaitu: faktor eksternal dan faktor internal. Faktor eksternal terdiri dari lingkungan dan fasilitas belajar, karakteristik Bahasa Inggris Teologi, metode pembelajaran dan penilaian prestasi belajar. Faktor internal terdiri dari sikap negatif terhadap Bahasa Inggris Teologi dan inteligensi.
Kata Kunci: Demotivasi, ESP Classroom, Bahasa Inggris Teologi
Return on Asset pada Perusahaan Sub Sektor Farmasi: Studi Pengaruh Sales Growth, Current Ratio dan Net Profit Margin
Authors: Nurfitria Nurfitria , Pakpahan Rosma , Laksana Banter 
Published: July 2022

This research aims to explain the effect of Sales Growh, Current Ratio, and Net Profit Margin on Return On Asset in pharmaceutical sub-sector companies listed on BEI in 2015-2020. The research method used is associative method with a quantitative approach. The source of data used is secondary data in the form of annual reports of pharmaceutical companies. Sampling technique is using porposive sampling technique and obtained a total sample of 6 pharmaceutical companies from 11 pharmaceutical companies listed on BEI in 2015-2020. The type of data used is panel dataa. Data analysis in this research is multiple linear regression using IBM SPSS Statisticss25 Software. The result showed that Sales Growth, Current Ratio (CR) and Net Profit Margin (NPM) Simultaneously have a significant effect on ROA. Partially, Sales Growth has a negative and insinigficant effect on ROA. While the Current Ratio(CR) and Net Profit Margin (NPM) have a positive and significant effect on ROA.