bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-Wide characterization and expression in analysis of PRR gene family in Glycine max and Glycine soja
Authors: Wenli Wang , Xueyan Qian , Hongmei Qiu , Guangxun Qi , Yingnan Wang , Lingchao Dong , Xiaodong Liu , Yumin Wang , Hongkun Zhao , Cuiping Yuan , Ziye Song , Jiayue Liu , Meizhu Zheng , Yingshan Dong , Yuqiu Li 
Published: November 2022

Abstract
Background
The genes in the PRR family are key components of the transcription-translation circadian network in plants, and comprise the core genes in the central oscillator translation feedback loop of Arabidopsis sp. They play important roles in several physiological processes and environmental adaptation. However, there is little information regarding the PRR genes of soybean, which is an important food crop. A genome-wide study of the PRR genes of soybean was performed herein using the available complete genome sequences of Glycine max and Glycine soja.
Results
In total, 12 PRR genes of G. max (GmPRR) and 14 PRR genes of G. soja (GsPRR) were identified and labelled according to their chromosomal location. The sequence length, relative molecular weight, and subcellular localization of the encoded proteins were predicted, and fundamental information was obtained for the genes. GmPRR and GsPRR were further categorized into three main groups based on their phylogenetic characteristics. The gene structures and characteristics of protein motifs were similar in the same subfamily. Conserved domain analyses of the proteins revealed that the integrity of the conserved domains differed among proteins from different subfamilies. GmPRR genes were absent on chromosomes 11 and 12, contrary to GsPRR genes. The results indicated that fragment replication events played an important role in the amplification of GmPRR and GsPRR genes. Intergenomic collinearity analysis of G. max, G. soja, and A. sp. revealed that the PRR genes of soybean and A. sp. were highly homologous. Analysis of transcriptome data revealed that the expression patterns of GmPRR genes differed at different times. Quantitative polymerase chain reaction (qPCR) analyses determined the relative transcript abundances of the different GmPRR and GsPRR varied across the studied plant materials.
Conclusions
In this study, 12 PRR genes of G. max (GmPRR) and 14 PRR genes of G. soja (GsPRR) were identified, and the structure, evolution, and expression patterns of the encoded proteins were investigated. The results of systematic analysis provides a basis for the subsequent identification of the functions of PRR genes, and the preliminary data can be used for analyzing the specific functions of the PRR genes of soybean.
A large intra-abdominal desmoid tumor in a young male: A case report
Authors: Kim Sung Jung , Han Jung Woo , Han Yoon Dae 
Published: November 2022

Abstract
Desmoid tumor is a mesenchymal originating fibroblastic proliferation, with no metastasizing potential but is locally aggressive. Although recent consensus merge into observation and active surveillance for desmoid tumor, symptomatic tumors, tumors with persistent growth, and intra-abdominal or abdominal wall desmoid tumors may need prompt surgical treatment. Here we report a patient with 38cm-sized intra-abdominal desmoid tumor who were successfully treated with surgical resection due to nonresponsiveness of chemotherapy and progression of symptoms. The patient is recurrence-free for two years, and further follow up is expected. Surgical treatment still resides as an optimal treatment modality for large intra-abdominal desmoid tumors.
Acceptability of mandatory vaccination against influenza, measles, pertussis and varicella by workers in healthcare facilities: a national cross-sectional study, France, 2019.
Authors: Vaux Sophie , Fonteneau Laure , Pefau Muriel , Venier Anne-Gaëlle , Gautier Arnaud , Altrach Sophan Soing , Parneix Pierre , Levy-Bruhl Daniel 
Published: November 2022

Abstract
Background:
Vaccination of healthcare workers (HCW) aims to protect them and to reduce transmission to susceptible patients. Influenza, measles, pertussis, and varicella vaccinations are recommended but not mandatory for HCW in France. Insufficient vaccine coverage for these diseases in HCW has raised the question of introducing mandatory vaccination. We conducted a survey to estimate acceptability of mandatory vaccination for these four vaccines by HCW working in healthcare facilities (HCF) in France, and to identify associated determinants.
Methods:
In 2019, we performed a cross-sectional survey of physicians, nurses, midwives and nursing assistants working in HCF in France using a randomised stratified three-stage sampling design (HCF type, ward category, HCW category). Data were collected in face-to-face interviews using a tablet computer. We investigated the possible determinants of acceptability of mandatory vaccination using univariate and multivariate Poisson regressions, and estimated prevalence ratios (PR).
Results:
A total of 8594 HCW in 167 HCF were included. For measles, pertussis, and varicella, self-reported acceptability of mandatory vaccination (very or quite favourable) was 73.1% [CI95%: 70.9–75.1], 72.1% [69.8–74.3], and 57.5% [54.5–57.7], respectively. Acceptability varied according to i) HCW and ward category for these three vaccinations, ii) age group for measles and pertussis, and iii) sex for varicella. For mandatory influenza vaccination, acceptability was lower (42.7% [40.6–44.9]), and varied greatly between HCW categories (from 77.2% for physicians to 32.0% for nursing assistants).
Conclusion:
HCW acceptability of mandatory vaccination was high for measles, pertussis and varicella but not as high for influenza. Vaccination for COVID-19 is mandatory for HCW in France. Replication of this study after the end of the COVID-19 crisis would help assess whether the pandemic had an impact on their acceptability of mandatory vaccination, in particular for influenza.
An evolutionary ecomorphological perspective on the assembly of a Neotropical bat metacommunity
Authors: Acero-Murcia Adriana Carolina , Severgnini Marcos R. , Fischer Erich , Provete Diogo B. 
Published: November 2022

Abstract
The evolution of bat skull has been extensively studied at a broad scale. However, we know little about how phenotypes that evolved in response to selective pressure elsewhere interact with ecological pressures to determine species co-ocurrence in human-modified landscapes. Here, we test the influence of size, diet, and foraging strategy on the skull and jaw shape of 32 co-occurring bat species in an agroecological landscape from southwestern Brazil. We used 2D geometric morphometrics for skull and jaw and phylogenetic comparative methods to integrate morphology, ecology, and phylogeny data. Our results show that closely related species were clustered together in the morphospace. Likewise, ecology and phylogeny influenced the cranial and jaw shape. Groups with greater phenotypic disparity were animalivores and insectivores. The skull of frugivores and animalivores were larger than that of insectivores and had a common and positive allometric relationship, probably related to olfactory-visual senses. Apparently, coexistence in Stenodermatinae frugivores is possible because they have optimal phenotypes for exploration food resources related to the skull and jaw size. Conversely, insectivores that clustered together in the morphospace had differences in foraging strategy or size.
p130Cas is required for androgen-dependent postnatal development regulation of submandibular glands
Authors: Gao Jing , Li Aonan , Fujii Shinsuke , Huang Fei , Nakatomi Chihiro , Nakamura Ichiro , Honda Hiroaki , Kiyoshima Tamotsu , Jimi Eijiro 
Published: November 2022

Abstract
Salivary glands develop through epithelial-mesenchymal interactions and are formed through repeated branching. The Crk-associated substrate protein (p130Cas) serves as an adapter that forms a complex with various proteins via integrin and growth factor signaling, with important regulatory roles in several essential cellular processes. We found that p130Cas is expressed in ductal epithelial cells of the submandibular gland (SMG). We generated epithelial tissue-specific p130Cas-deficient (p130CasΔepi–) mice and aimed to investigate the physiological role of p130Cas in the postnatal development of salivary glands. Histological analysis showed immature development of granular convoluted tubules (GCT) of the SMG in male p130CasΔepi– mice. Furthermore, epidermal growth factor (EGF)-positive secretory granules contained in GCT cells were significantly reduced in p130CasΔepi– mice with downregulated androgen receptor signaling. Deficiency of p130Cas resulted in a decrease in Rab3D-positive vesicles, disturbed intracellular localization of the cis-Golgi matrix protein GM130, and decreased expression of endoplasmic reticulum (ER) markers such as Lys-Asp-Glu-Leu (KDEL) and calnexin in GCT cells. Thus, p130Cas plays a crucial role in androgen-dependent GCT development in SMG by regulating the formation of the ER-Golgi network.
STING mediates experimental osteoarthritis and the associated pain behavior in mouse
Authors: Shin Youngnim , Cho Deborah , Kim Seul Ki , Chun Jang-Soo 
Published: November 2022

Abstract
Background. This study was performed to develop therapeutic targets of osteoarthritis (OA) that can be targeted to alleviate OA development (i.e., cartilage destruction) and relieve the OA-associated joint pain.
Methods: The candidate molecule, STING (stimulator of interferon genes, encoded by Sting1), was identified by microarray analysis of OA-like mouse chondrocytes. Experimental OA in mice was induced by destabilization of the medial meniscus (DMM). STING functions in OA and joint pain were evaluated by gain-of-function (intra-articular injection of a STING agonist) and loss-of-function (Sting1-/- mice) approaches.
Results: DNA damage was observed in OA-like chondrocytes. Cytosolic DNA sensors, STING and its upstream molecule, cGAS (cyclic GMP-AMP synthase), were upregulated in OA chondrocytes and cartilage of mouse and human. Genetic ablation of STING in mice (Sting1-/-) alleviated OA manifestations (cartilage destruction and subchondral bone sclerosis) and OA-associated pain behavior. In contrast, stimulation of STING signaling in joint tissues by intra-articular injection of cGAMP exacerbated OA manifestations and pain behavior. Mechanistic studies on the regulation of OA pain revealed that STING regulates the expression of peripheral sensitization molecules in the synovium and meniscus of mouse knee joints.
Conclusion: Our results indicated that the cGAS-STNG pathway in chondrocytes, which senses damaged cytosolic DNA and accordingly activates the innate immune response, regulates OA pathogenesis and joint pain. Therefore, inhibition of STING could be a therapeutic approach to inhibit OA cartilage destruction and relieve the associated pain in model mice.
Investigating the effect of PAMAM-G2 nanostructures dendrimer on the performance of polycarbonate thin film nanocomposite membranes for water treatment
Authors: Khezraqa Homayun , Etemadi Habib , Salami-Kalajahi Mehdi 
Published: November 2022

Abstract
For the first time, thin film nanocomposite membranes (TFN) were fabricated using polyamidoamine polymer nanostructures(PAMAM-G2) through the use of the dip-coating method that polyvinyl alcohol (PVA)/PAMAM-G2 solution was applied to polycarbonate (PC) support membranes. The Fourier transform infrared (FTIR) and thermal gravimetric analysis (TGA) confirmed the synthesis PAMAM dendritic structure. At vacuum trans-membrane pressures (TMP) of 0.4 and 0.6 bar, all fabricated membranes were utilized to remove humic acid (HA) from submerged membrane filtration. PVA/ PAMAM-G2 top active layer formed on the PC support membrane was verified by images obtained using field-emission scanning electron microscopy (FESEM) and attenuated total reflectance-Fourier transform infrared (ATR-FTIR) equipment. FESEM images show that a PVA-PAMAM.G2 top layer with a thickness of 201.85 nm was developed on the PC support layer. TFN membranes' hydrophilicity and surface roughness increased and decreased respectively as a result of the incorporation of PAMAM-G2. The TFN with 0.1 weight percent of PAMAM-G2 nanostructures demonstrated increased permeation flux at lower vacuum TMP, according to the results of HA filtration. However, TMP permeate flow significantly decreased at higher vacuum conditions. The rejection rate for TFC membranes was about 97.9% while for TFN membranes in the presence of PAMAM-G2 polymeric nanostructure it reached 98.5%.
Plasmonic Dielectric Response of Finite Temperature Electron Gas
Authors: Akbari-Moghanjoughi Massoud 
Published: November 2022

Abstract
In this research we report the dielectric response of a finite temperature electron gas, electrostatically interacting with both external and self-induced plasmonic fields, in the well-known random phase approximation. The generalized energy dispersion relation which incorporates the plasmonic band structure is used to calculate the Lindhard dielectric response of homogenous electron gas from which many important physical functionals, such as the structure factor, loss function, screening potential, optical reflectivity and electronic stopping power are deduced. The present dual length-scale theory of dielectric response incorporates both single electron as well as collective electrostatic oscillation of electrons which, due to the Van-Hove-like singularity at plasmon wavenumber, shows distinct features of plasmonic response to electromagnetic interactions of the electron gas with arbitrary degree of electron degeneracy. It is shown that the static impurity charge screening potential is oscillatory Lennard-Jones-type attractive potential which is quite different from both predicted by the Conventional noninteracting Lindhard theory and the Shukla-Eliasson attractive potential obtained from quantum hydrodynamic approach. It is also revealed that due to resonant electron-plasmon interactions and multi-pole structure of the electronic response function the Landau damping region is scattered. The findings of current research may have important implications for a wide range of physical phenomena relevant to a broad nonrelativistic electron density-temperature regime, from the laboratory scale semiconductors and nanoelectronic technology to the warm dense matter state.
The Contribution of the Single-knot Fascia Closure as a New Technique in Reducing Postoperative Cesarean Section Pain
Authors: Atilgan Remzi , Pala Şehmus , Halisçelik Mesut Ali , Şenocak Ahmet , Çim Bünyamin 
Published: November 2022

Abstract
Introduction: After cesarean section, many women complain of postoperative incision site and abdominal pain. Surgical techniques can be effective in relieving this pain to some extent. We compared the effects of single-knot fascia closure technique and classical fascia closure technique on postoperative pain in fascia closure.
Methods: A total of 80 cases were included in this prospective, randomized, single-center study. Classical fascia closure method was applied to one group and single-knot fascia closure method was applied to the other group. Pain was evaluated with Visual Analogue Scala (VAS) at 8 and 24 hours postoperatively. The cases were followed up for the development of infection, hematoma, seroma and hernia at the wound site within 3 months postoperatively.
Results: Wound infection, seroma, hematoma and hernia did not develop in the postoperative period in both groups. However, VAS values ​​at the 8th and 24th hours were significantly lower in the group in which the single knot fascia closure method was applied.
Conclusion: Single-knot fascia closure method is an effective and reliable method in reducing postoperative pain after cesarean section.
Strategies for Reducing Communication Latency in 6G Networks
Authors: Das Satya Ranjan , Mukherjee Nandini , Sinha Bhabani P 
Published: November 2022

Abstract
Design of computer networks usually aims at optimizing the network performance through efficient network communication protocols to maximize resource utilization and network throughput. Over the different generations of wireless cellular network staring from first (1G) to fifth generation (5G), end-to-end communication latency, bandwidth and energy required for communication have turned out to be the most significant performance parameters to be considered for the design process. Although a significant amount of research has been done in this direction over the last few decades, still lot more attention needs to be given to explore the techniques for improving the end-to-end communication latency specifically in the context of recent 5G and 6G networks. This paper initially presents the expected goals of the 6G networks and the potential smart services to be enabled by 6G. In the later sections, it provides a concise survey of strategies for managing latency-related issues in the literature. Next we focus on the types and sources of delays that affect latency, the enabling technologies for 6G implementation and the potential strategies for reducing latency. Finally, we discuss about some significant challenges and identify a few open research problems to achieve ultra-low end-to-end latency in 6G communication.
Enhanced production of falcarinol-type polyacetylenes in hairy roots of cultivated carrot (Daucus carota subsp. sativus)
Authors: Dunemann Frank , Böttcher Christoph 
Published: November 2022

Abstract
Polyacetylenes (PAs) are a large group of bioactive phytochemicals, which are primarily produced by higher plants of the families Apiaceae and Araliaceae. Especially aliphatic C17-polyacetylenes of the falcarinol-type such as falcarinol (FaOH) and falcarindiol (FaDOH) are known for their numerous biological functions including positive effects on human health. In this study we investigate the potential of carrot hairy root (HR) cultures for accumulation of PAs in vitro. Three individual plants of seven differently colored carrot cultivars were used for the development of HR cultures by transformation of root discs with the wild-type Rhizobium rhizogenes strain 15834. A total of 51 individual HR lines were established and quantitatively analysed by HPLC/DAD together with root, petiole and leaf tissue samples for their FaOH and FaDOH levels. Among the five tissues sampled from the donor plants, root periderm samples generally exhibited the highest PA levels with FaDOH as prevailing PA and large differences between cultivars. Compared with the periderm, FaOH levels were highly increased in HRs of all investigated carrot cultivars, whereas the FaDOH levels were only slightly enhanced. Considering the low to moderate PA concentration in root and leaf tissues of the orange cultivars there was an up to 30-fold increase of the FaOH concentration in HRs derived from orange genotypes. In this study, we demonstrate, that carrot HRs are able to produce large amounts of PAs. Hence, we suggest that HRs might be a suited tool to assess the function of candidate genes involved in the biosynthesis of major PAs.
Sustainable Synthesis of Benzylidenemalononitrile Compounds Under Microwave-
Irradiation
Authors: Jimenez David E.Q. , Zanin Lucas L. , Ferreira Irlon M. , Deflon Victor M. , Diniz Luan F. , Ellena Javier , Haiduke Roberto L.A. , Porto André L. M. 
Published: November 2022

Abstracts:
A green methodology was developed to obtain a large scope of Knoevenagel adducts with high yields (77-95%). The compounds were synthetized in 30 min, using aromatic aldehyde derivatives, malononitrile, water as a solvent, microwave irradiation as a heating source and in free-catalyst conditions. In a particular case, in the synthesis of the adduct derived from the α-methyl-trans-cinnamaldehyde, a [2+2] photochemical cycloaddition product was observed, a tetrasubstituted cyclobutane dimeric compound 3w’. Its complex structure was confirmed by X-ray diffraction (first time), nuclear magnetic resonance analysis and electronic structure calculations. Theoretical results suggest that the thermal decomposition of 3w’ back to 3w can occur by means of a biradical intermediate.
The Flavonoid Components of Scutellaria baicalensis: Biopharmaceutical
Properties and their Improvement using Nanoformulation Techniques
Authors: Pi Jiaxin , Wang Jilin , Feng Xiaojiao , Li Ziwei , Liu Yiting , Yang Wenzhuo , Zhang Tingen , Guo Pan , Liu Zhidong , Qi Dongli 
Published: November 2022

Abstract:
Scutellaria baicalensis georgi, known as “Huangqin” in its dried root form, is a herb widely used in traditional Chinese medicine for “clearing away heat, removing dampness, purging fire and detoxification”. Baicalin, baicalein, wogonin, and wogonoside are the main flavonoid com-pounds found in Scutellaria baicalensis. Scutellaria baicalensis flavonoid components have the po-tential to prevent and treat a host of diseases. The components of S. baicalensis have limited clinical application due to their low water solubility, poor permeability, and microbial transformation in vi-vo. Nanopharmaceutical techniques can improve their biopharmaceutical properties, enhance their absorption in vivo, and improve their bioavailability. However, due to the limited number of clinical trials, doubts remain about their toxicity and improvements in human absorption as a result of nanoformulations. This review summarizes the latest and most comprehensive information regard-ing the absorption, distribution, metabolism, and excretion of the Scutellaria baicalensis compo-nents in vivo. We examined the main advantages of nanodrug delivery systems and collected de-tailed information on the nanosystem delivery of the Scutellaria baicalensis components, including nanosuspensions and various lipid-based nanosystems. Lipid-based systems including liposomes, solid lipid nanoparticles, nanoemulsions, and self-micro emulsifying drug delivery systems are in-troduced in detail. In addition, we make recommendations for related and future research directions. Future research should further examine the absorption mechanisms and metabolic pathways of nanoformulations of the components of Scutellaria baicalensis in vivo, and accurately track the in vivo behavior of these drug delivery systems to discover the specific reasons for the enhanced bioa-vailability of nanoformulations of the scutellaria baicalensis components. The development of tar-geted oral administration of intact nanoparticles of Scutellaria baicalensis components is an excit-ing prospect.