bluuebunny/crossref_metadata_2025_split huggingface dataset:
A quality‐of‐life meta‐analysis comparing pre‐ and postoperative symptoms in women undergoing colorectal resection for deep infiltrating endometriosis
Authors: Maguire Barry , DeMaio Alison , O'Neill Aoife , Clancy Cillian 
Published: February 2025

AbstractAimDeep infiltrating endometriosis (DIE) may involve the rectum or colon and is associated with pain, gastrointestinal dysfunction and reduced quality of life (QoL). While hormonal treatment may be effective, surgical intervention including colorectal resection can be required. Colorectal resection can result in functional changes and complications, which can also impair QoL. The aim of this study is to examine all available comparative pre‐ and postoperative data on QoL and symptom outcomes following colorectal resection for DIE.MethodAn electronic database search was conducted for studies reporting pre‐ and postoperative QoL and symptom outcomes following colorectal resection for DIE. The study was registered with PROSPERO and followed PRISMA (Preferred Reporting Items in Systematic Reviews and Meta‐analyses) guidelines. Data were combined using random‐effects models.ResultsFourteen studies including 1142 patients were included. Colorectal resection was associated with improved outcomes for all items in the SF‐36 QoL questionnaire as well as symptom outcomes including dysmenorrhoea, chronic pelvic pain and deep dyspareunia. Importantly, the gastrointestinal QoL index was significantly improved (mean difference 24.50, 95% CI 15.93–33.08, p < 0.0001) as was dyschezia (mean difference −4.1, 95% CI −4.77 to −3.42, p < 0.0001). There was no change in low anterior resection syndrome scores (mean difference −5.28, 95% CI −11.65 to 1.10, p = 0.1046).ConclusionThis study demonstrates a significant postoperative improvement in patient‐reported QoL, pain symptoms and gastrointestinal function following colorectal resection for endometriosis.
Lignocellulose‐based Stryphnodendron adstringens bark as a natural dye source for textiles: Extraction and dyeing studies
Authors: Silva Patricia Muniz dos Santos , Freeman Harold S. , da Costa Silgia Aparecida , Santos Douglas da Silva , de Lima Fernando Soares , de Queiroz Rayana Santiago , Rossi Fiaschitello Ticiane , da Costa Sirlene Maria 
Published: February 2025

AbstractNatural dyes are gaining interest as a more ecological approach to textile coloration, as well as for slow fashion and the bioeconomy. The use of local raw materials is a way of valuing small producers and recovering traditional knowledge. In this context, the current investigation was developed to study the use of lignocellulose‐based Stryphnodendron adstringens (Mart.) Coville (known as “barbatimão”) bark extract, from a native tree in Brazil, as a natural dye for textile dyeing. Physical–chemical analyses were performed on the reddish‐brown extract, the results of which showed an acidic pH and the likely presence of condensed tannins and flavanols. The optimised dyeing process was evaluated by a 23 factorial design. The fabrics dyed under optimised conditions were evaluated for colour fastness to laundering, rubbing, light and perspiration, and obtained good colour fastness ratings in most of these tests. Wastewaters from dyeings were characterised by physicochemical analyses. Because of the high turbidity and high biochemical oxygen demand and chemical oxygen demand levels, as well as the amount of residual metal ions from dyeing with mordants, the need for wastewater pretreatment was evident. Based on this research, S. adstringens extracts have significant potential for textile coloration.
“Milking the lions”: An analysis of conservation performance payments in eastern and southern Africa
Authors: Hamm Joseph , Holmes George , Mabele Mathew Bukhi , Martin‐Ortega Julia 
Published: February 2025

AbstractConservation performance payments (CPPs) aim to encourage coexistence between humans and large carnivores by tying payments to species presence or abundance. While there is growing interest in the development of these programs, they remain the subject of little empirical research. Furthermore, there is no literature on CPPs for carnivores in Africa, despite the continent's global importance in carnivore conservation and the fact that multiple such schemes are currently in operation. This research establishes where and how these schemes function and identifies recurring challenges associated with their implementation. We conducted semi‐structured interviews with representatives of nine conservation performance payment programs operating across five countries in eastern and southern Africa. We find that despite their theoretical simplicity, local complexities, and pragmatism mean there is significant variation in how CPPs operate. This includes differences in monitoring methods, governance, and all aspects of payments. The inclusion of input conditionality (i.e., fines or bonuses for certain actions) in a majority of schemes also challenges the prevailing conceptualization of CPPs as entirely results‐based. Recurring challenges include securing long‐term funding, setting suitable payment levels, and ensuring equitable governance. Practitioners view performance payments as a promising approach for carnivore conservation, but their roll‐out risks moving faster than our understanding of them.
Myocardial Perfusion Scintigraphy Provides Incremental Prognostic Value in Patients on the Kidney Transplant Waiting List
Authors: Reuter Stefan , Reiermann Stefanie , Stypmann Jörg , Bautz Joachim , Schütte‐Nütgen Katharina , Pavenstädt Hermann , Malyar Viola , Reinecke Holger , Kurosinski Marc‐Andre , Görlich Dennis , Hense Hans‐Werner , Suwelack Barbara , Schäfers Michael 
Published: February 2025

ABSTRACTThe approach to cardiovascular risk assessment before renal transplantation is still controversial. Therefore, we evaluated and compared the prognostic value of myocardial perfusion scintigraphy (MPS) and dobutamine stress echocardiography (DSE) in patients with end‐stage renal disease (ESRD) who are candidates for kidney transplantation (KTx). Methods: We prospectively enrolled 356 ESRD clinical transplantations for review, only patients (NCT01064674) admitted to our transplant center between August 2009 and July 2012. Cardiovascular risk assessment at the time of listing was based on the Münster Cardiovascular Risk Stratification Score (MCRSS), additionally including evaluation by DSE and MPS in all ESRD patients. Coronary angiography was conducted in patients at high risk according to the MCRSS and in those where noninvasive stress testing revealed stress‐induced ischemia or wall motion abnormalities. Results: During long‐term follow‐up until October 2020, 2.43 cardiovascular events/100 person‐years (nonfatal stroke, nonfatal myocardial infarction, and cardiovascular death) occurred, and the overall patient survival was 71.9%. Mild perfusion deficits identified by MPS, unlike wall motion abnormalities detected by DSE, showed incremental prognostic value for event‐free survival in patients with low MCRSS risk. Conclusion: We therefore propose a modified MCRSS‐based approach including MPS as a reasonable risk stratification approach for cardiovascular risk assessment of ESRD patients applying for KTx.
Low Proarrhythmic Risk of Imetelstat, a Novel Oligonucleotide Telomerase Inhibitor: A Translational Analysis
Authors: Lennox Ashley L. , Sun Libo , Huang Fei , Behrs Melissa Kelly , Kleiman Robert , Xue Hongqi , Bhise Neha , Wan Ying , Berry Tymara , Feller Faye , Morcos Peter N. 
Published: February 2025

ABSTRACTEvaluation of the proarrhythmic potential of imetelstat, a novel oligonucleotide telomerase inhibitor, in nonclinical and clinical studies is presented. In vitro, imetelstat sodium ≤ 750 μg/mL and negative (vehicle) and positive (cisapride) controls were evaluated for hERG channel current inhibition. In vivo, cynomolgus monkeys received a single vehicle control or imetelstat sodium (5 mg/kg [2‐h infusion], 10 mg/kg [6‐h infusion], or 15 mg/kg [6‐ or 24‐h infusion]); cardiovascular parameters were collected before and after drug administration. A ventricular repolarization substudy of the IMerge phase III study evaluated patients with lower‐risk myelodysplastic syndromes administered imetelstat 7.1 mg/kg active dose every 4 weeks; intensive electrocardiograms and pharmacokinetic samples were collected for concentration‐QTc and by‐time point analyses after a single dose. In vitro, imetelstat did not inhibit the hERG channel (IC50 > 750 μg/mL). In monkeys, imetelstat demonstrated no treatment‐related changes in cardiac parameters, including QTc using Fridericia correction (QTcF). In the IMerge QTc substudy, 45 patients received imetelstat (n = 29) or placebo (n = 16). The concentration‐QTc relationship was described by a linear mixed‐effects model; at the geometric mean maximum plasma concentration (Cmax) for imetelstat 7.1 mg/kg of 89.5 μg/mL, the predicted effect on placebo‐corrected change from baseline QTcF was 2.36 ms (90% confidence interval, −3.04 to 7.76), supporting no evidence of QTcF prolongation. By‐time point analysis demonstrated no clinically significant effect of imetelstat on QTc. Nonclinical studies demonstrated no proarrhythmic risk at > 140× (in vitro) and > 2.6× (in vivo) imetelstat 7.1 mg/kg Cmax. Clinical evaluations showed no significant effects on QTcF or other electrocardiogram parameters at 7.1 mg/kg. Collectively, this integrated risk assessment supports the low proarrhythmic potential of imetelstat.
The property of larval cells of the scleractinian coral, Acropora tenuis, deduced from in vitro cultured cells
Authors: Kawamura Kaz , Sekida Satoko , Nishitsuji Koki , Satoh Noriyuki 
Published: February 2025

AbstractIn previous studies, we have established approximately 15 cultured cell‐lines derived from planula larvae of Acropora tenuis. Based on their morphology and behavior, these cells were classified into three types, flattened amorphous cells (FAmCs), vacuolated adherent cells (VAdCs), and small smooth cells (SSmCs). FAmCs include fibroblast‐like cells and spherical, brilliant brown cells (BBrCs), which are transformable to each other. To examine the larval origin of the three cell types, we raised antibodies: anti‐AtMLRP2 that appears to recognize FAmC, anti‐AtAHNAK for BBrC, anti‐AtSOMP5 and anti‐AtEndoG for SSmC, and anti‐AtGal and anti‐AtFat4 for VAdC, respectively. Anti‐AtMLRP2 antibody stained in vivo stomodeum and neuroblast‐like cells embedded in larval ectoderm around the aboral pole. Anti‐AtAHNAK antibody stained neuron‐like and neuroblast‐like cells, both of which were also stained with neuron‐specific tubulin β‐3 antibody. These results suggest that in vitro BBrCs and in vivo neuroblast‐like cells share neuronal properties in common. Two antibodies for SSmCs, anti‐AtSOMP5 and anti‐AtEndoG, stained larval ectoderm cells, suggesting that SSmCs have larval ectoderm properties. Two antibodies for VAdCs, anti‐AtGal and anti‐AtFat4, stained larval endoderm cells, suggesting that VAdCs have larval endoderm properties. Therefore, the in vitro cell lines appear to retain properties of the stomodeum, neuroblast, ectoderm, or endoderm. Each of them may be used in future investigations to reveal cellular and molecular properties of cell types of coral larvae, such as the potential for symbiosis.
Clinical Outcomes of Intracardiac Echocardiography‐Guided Radiofrequency Catheter Ablation for Atrial Fibrillation: A Retrospective Study
Authors: Long Weiying , He Qingsong , Chen Shi , Luo Xue , Yang Wucheng , Zheng Jia , Fu Hua 
Published: February 2025

ABSTRACTBackgroundRoutine radiofrequency catheter ablation relies on x‐ray imaging, which may increase the risk of radiation exposure to patients. With the rapid development of intracardiac echocardiography (ICE) technology, it provides a new guidance modality for radiofrequency catheter ablation and shows great potential for application in the treatment of atrial fibrillation (AF).ObjectiveTo assess the efficacy and safety of intracardiac echocardiography guided radiofrequency catheter ablation for the treatment of AF.MethodsA retrospective cohort study was used to collect 184 patients who underwent radiofrequency catheter ablation for the treatment of AF from January 2020 to September 2021 in the cardiovascular medicine department of our hospital. According to whether they used ICE or not, they were divided into the ICE group (30 cases) and the non‐ICE group (154 cases). The procedure of the intervention, complications during the intervention and follow‐up periods, use of early anticoagulation and antiarrhythmic medications, and the success rate of AF ablation 1 year after the intervention were compared between the two groups.ResultsIn comparison to the non‐ICE group, the septal puncture time (6.27 ± 1.91 min vs. 7.21 ± 2.08 min, p = 0.022), left atrial modeling time (4.93 ± 1.84 min vs. 5.75 ± 1.96 min, p = 0.035), and total ablation time (67.73 ± 2.64 min vs. 73.35 ± 1.96 min, p < 0.001) in the ICE group were significantly reduced. Radiation exposure time (5.09 ± 0.23 min vs. 13.17 ± 0.28 min, p < 0.001) and radiation exposure (33.13 ± 1.99 mGy/cm2 vs. 217.6 ± 15.17 mGy/cm2, p < 0.001) also were significantly less in the ICE group than in the non‐ICE group. The incidence of postintervention nausea and vomiting (3.33% vs. 19.48%, p = 0.032), and hypotension (3.33% vs. 18.83%, p = 0.033) was significantly lower in the ICE group than in the non‐ICE group. Furthermore, the proportion using amiodarone in the first 3 months during follow‐up was significantly lower for the ICE group than for the non‐ICE group (40.00% vs. 63.64%, p = 0.024), and the rate of late recurrence remained unchanged in the ICE group, while there was a trend toward an increase in the rate of late recurrence in the non‐ICE group. One year after the operation, the success rates of AF ablation in the ICE group and non‐ICE group were 80.00% and 77.92%, and the difference between the groups was not statistically significant (p = 0.825).ConclusionICE‐guided radiofrequency catheter ablation is safe and effective in the treatment of AF, and it has potential advantages in terms of ablation time, radiation exposure, complication occurrence, and patient prognosis.
From Awareness to Action: A Study of Capacity‐Building Engagement Techniques for Fostering Climate‐Adaptive Behaviours in Citizens
Authors: Baldelli Madeline , Mattera Marina , Renou‐Wilson Florence 
Published: February 2025

ABSTRACTRising threats from climate change have demanded the creation of effective adaptation strategies and frameworks to help prepare communities against adverse environmental impacts. While successful climate adaptation requires support and cooperation between governments and the public, many governments lack the capacity or support necessary to gain public trust and effectively enforce adaptation strategies. Capacity‐building strategies can aid governments and the public in this regard. Through a thematic literature review and Delphi study, this research reports on the most effective capacity‐building methods for citizen engagement to create behavioural change towards climate adaptation. Results show that effective citizen engagement can lead to increased climate adaptation support as well as behavioural change in citizens and that multiple capacity‐building methods (i.e., education/training, youth empowerment, etc.) are needed for effective citizen engagement in climate adaptation. Hence, governments should focus on bottom‐up communication and facilitation techniques when engaging with citizens and communities on climate adaptation.
Effect of Trace Sc Addition on Aging Precipitation and Fatigue Crack Propagation Behavior of 7085 Alloy
Authors: Ren Qianqian , Deng Xianjing , Ru Zhiqiang , Liu Ming , Pi Zhimin , Wei Lili , Huang Hongfeng , Li Degui 
Published: February 2025

ABSTRACTIn this work, the effects of Sc‐alloying and aging treatments, including T6 peak‐aging and retrogression with reaging (RRA) on the fatigue crack propagation (FCP) behavior of 7085 alloy, were investigated. The results show that the RRA‐treated alloy exhibits high volume fraction of larger sharable η′ phases, wider precipitate free zone (PFZ), and high Schmid factor. These microstructures contribute to frequent transgranular propagation, increasement of ΔKth, and higher FCP resistance than T6‐treated alloy. Sc alloying can significantly refine grain structure, inhibit recrystallization, and accelerate the nucleation of η′ strengthening phase, thus improving the mechanical properties of 7085 alloy. However, Sc alloying also tends to induce the occurrence of intergranular propagation due to presence of microscale AlZnMgCuSc phase and fine grain structure with high grain boundary volume fraction. Therefore, Sc alloying plays a negative role in improving the FCP resistance of 7085 alloy.
Characterization of TiN−HA nanocomposite developed through rapid microwave sintering route at high temperature
Authors: Kumar Chintam Suresh , Gupta Shivani , Sharma Apurbba Kumar 
Published: February 2025

AbstractTitanium is one of the most suitable metals used in medical implants. Titanium alloys and titanium‐based ceramics are widely used in orthodontics and orthopedic applications. In addition, titanium‐based composites are preferred biomaterials for orthopedic applications and bioactive coatings. This work focuses on using relatively stable TiN material for the fabrication of TiN−HA composite through a rapid sintering technique at a process temperature of ∼1400–1450°C in a modified domestic microwave applicator at 800 W power. Microwave sintered nanocomposites were characterized in terms of density, measurement of microhardness, analysis of microstructures, and indentation fracture toughness. Sintered nanocomposites (with 15 wt% and 25 wt% HA) achieved ∼95% densification with comparable microhardness with respect to bulk TiN. However, the fracture toughness of the nanocomposites was compromised with the addition of the brittle HA phase when compared with pure TiN. The XRD results revealed an interaction between the constituent phases resulting in the formation of calcium titanate (CaTiO3) and α‐tri calcium phosphate (α‐Ca3(PO4)2) due to high processing temperature. Furthermore, microstructures clearly show good bonding between particles. The developed nanocomposites exhibited reasonable properties with biocompatible phases; consequently, the nanocomposites can be candidates for coating other metals and inert biomaterials.
High‐transparency AlON ceramics fabricated by pressureless sintering method
Authors: Zhao Yanan , Meng Xiangzhao , Li Yuanlin , Han Lin , Lei Xiaoping , Yang Xiao , An Ziyu , Kong Zhenzhu , Peng Bin , Liu Ming 
Published: February 2025

AbstractAlumina nitride (AlON) ceramics have the advantages of wide transmission ranges, high‐strength, and high‐hardness, and these characteristics make it have potential applications in the fields of national defense and aerospace. However, the prolonged high‐temperature (≥1900°C) sintering process severely reduces of its mechanical and optical properties far below the theoretical value in practice. In this work, we successfully fabricated AlON transparent ceramics exhibiting superior mechanical (bending strength of 293 MPa and hardness of 18 GPa) and optical properties (76.2% at 2100 nm), and the sintering temperature is approximately 50°C lower than that of conventional methods. Here, the first obtained high‐activity and high‐purity AlON powders through solid‐state reaction method with secondary ball milling process, could effectively reduce both the sintering temperatures and durations. Subsequently, by optimizing the doping content of Y2O3, AlON ceramics were sintered at 1850°C, in which represent the minimal porosity at the grain boundaries and fine grains of uniform size, still keeping the superior mechanical and optical properties. The methods developed in this work are not only suitable for the large‐scale production of high‐activity and high‐purity AlON powders but also for the preparation of large‐scale AlON ceramics by using the casting process in future.
Preparation of CaSiO3 porous scaffold via DLP 3D printing and its surface modification through in situ growth of HAp
Authors: Liu Yang , Sun Ruixue , Han Jianmin 
Published: February 2025

AbstractCalcium silicate (CaSiO3, CS) bioceramic has received widespread attention in the field of bone repair due to its excellent bone conductivity, osteoinductivtiy, and degradability. In this study, the porous CS scaffold was firstly prepared by digital light processing (DLP) 3D printing. The effects of solid loading, pore size, and sintering temperature on the compressive strength, porosity and shrinkage of the CS scaffold were thoroughly investigated. When the solid loading is 35 vol.%, the pore size is 500 µm, and the sintering temperature is 1200°C, the prepared CS scaffold has high porosity (48.96 %) and high compressive strength (32.13 MPa). To solve the problems caused by the rapid degradation of CS, surface modification of the prepared CS scaffold was further conducted through in situ growth of hydroxyapatite (HAp) on its surface. A large amount of HAp nanorods homogeneously grow on the surface of the CS porous scaffold when the concentration of KH2PO4 in hydrothermal solution is 0.01 mol/L. Moreover, the phase composition and morphology of HAp grown on the surface of the CS scaffold can be controlled through controlling the concentration of KH2PO4.
Sticky Objects and Places: Entangled Emotions in an English‐Medium University Educationscape
Authors: Hopkyns Sarah 
Published: February 2025

ABSTRACTThis paper explores entangled emotions in an Abu Dhabi English‐medium university educationscape in relation to sticky objects and sticky places, which are objects/places saturated in affect through familiarity and repetition. Moving away from a lingua‐centric approach to linguistic landscape research, this ethnographic study explores Emirati students’ emotions not only in relation to language as discourses but also in relation to semiotics, objects, and geopolitical meanings. Students’ interpretations of their semiotic and linguistic landscapes (LL) as “intertextual products” connected to emotions, identities, and levels of belonging were gained via virtual bulletin board posts and essays. Data were analyzed through thematic analysis and nexus analysis. Key findings revealed emotions of belonging in familiar and sentimental cultural and linguistic spaces and around sticky objects, comfort in “hidden places” as an escape from emotions of stress and pressure in the English‐medium instruction university, and the importance of critical awareness in the educationscape. Based on the findings, the article provides practical suggestions for ways to enhance linguistic and cultural belonging in English‐medium educationscapes and recognize emotional entanglements within multilingual university ecosystems.