bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of awareness of coronary artery disease patients regarding lifestyle modifications at Khartoum state
Authors: Hassan Wadeda , Jarelnape Ahmed , Elbasheer Albagier 
Published: April 2022

Abstract
Background: Coronary Artery Disease (CAD) is the leading cause of mortality and disability worldwide. An estimated 17.5 million people died globally due to Coronary Artery Disease (CAD) in 2020, representing 31% of all global deaths. Methods: A Descriptive cross-sectional study was conducted in a Sudan heart institute at Khartoum State- Sudan during a period from January 2020 to March 2020, aimed to assess the awareness of patient with Acute Coronary Syndrome (ACS) regarding life style modification. The study population consisted of 100 consecutive Coronary Artery Disease (CAD) patients aged less than 70 years who visit the outpatient clinic during the period of study. Physical examination, a careful medical interview with assessment for lifestyle habits, adherence to pharmacological therapy were performed. Results: Overall, patients had a high level of awareness about coronary artery disease (CAD) (68%), its risk factors, including obesity (95%), smoking (91%), hypertension (84%), DM (69%). Also, there was a relationship between the level of education and the definition of Coronary Artery Disease (CAD). However, the patients face the diﬃculty of modifying their lifestyle habits.Conclusions: There were substantial disparities in the confidence levels associated with lifestyle modification and recognition/response to heart attack. These gaps need to be studied further and disseminated to improve cardiovascular care.
A cross-sectional survey on the clinical management of emergence delirium in adults: knowledge, attitude, and practice in mainland China
Authors: Yuan Yi , Lei Bao , Li Zhengqian , Wang Xiaoxiao , Zhao Huiling , Gao Meng , Xue Yingying , Zhang Wenchao , Xiao Rui , Meng Xue , Zheng Hongcai , Zhang Jing , Wang Geng , Guo Xiangyang 
Published: April 2022

Abstract
Background: Emergence delirium (ED) occurs immediately after emergence from general anesthesia and is defined by restlessness, confusion, and combative or violent actions, which may cause several adverse consequences. To decrease its incidence, the anesthesia-related staff including anesthesiologists and anesthesia nurses are both essential for the early identification and intervention of ED in potential risky patients. However, the current management status for ED among Chinese anesthesiologists and anesthesia nurses is unknown. This cross-section survey aimed to assess Chinese physicians’ and nurses’ knowledge of, attitude and practice towards ED in adults. Methods: Electronic questionnaires were sent to 93 major academic hospitals across mainland China. One attending anesthesiologist and one anesthesia head nurse were recommended to complete the questionnaire. Results: 81 anesthesiologists and 71 anesthesia nurses participated in the survey. Most of the participants considered it as a very important issue and over 80% emphasized the essential role of anesthesia nurses during its management. However, less than 1/3 of participants routinely assessed ED. Specifically, anesthesiologists assessed patients only when presenting with delirium symptoms (46.9% of anesthesiologists vs. 26.8% anesthesia nurses, P=0.01), while anesthesia nurses did in all patients (25.4% of anesthesia nurses 8 vs.6% of anesthesiologists, P=0.006). Most participants preferred to diagnose ED based on symptoms. In terms of screening tools, anesthesiologists preferred Confusion Assessment Method, while anesthesia nurses reported multiple screening tools. Divergence also appeared in terms of monitoring the depth of anesthesia. Although the bispectral index was the most common monitoring tool, anesthesiologists monitored only in high-risk patients (60.5% of anesthesiologists vs. 36.6% anesthesia nurses, P =0.003), while the nurses did in all patients routinely (50.7% anesthesia nurses vs 29.6% of anesthesiologists, P=0.008). No unified treatment strategy nor medication was reported for ED treatment during the recovery period. Conclusions: This study illustrated that there are high awareness levels in both Chinese anesthesiologists and anesthesia nurses regarding the importance of ED. However, the specific practice in terms of routine delirium assessment, anesthesia depth monitoring, and a standardized treatment algorithm need to be implemented to improve ED management. Trial registration: not applicable.
Discovery, Isolation, Heterologous Expression and Mode-of Action Studies of the Antibiotic Polyketide Tatiomicin from Amycolatopsis sp. DEM30355
Authors: Kepplinger Bernhard , Mardiana Lina , Cowell Joseph , Morton-Laing Stephanie , Dashti Yousef , Wills Corinne , Marrs Emma , Perry John , Gray Joe , Goodfellow Michael , Errington Jeff , Probert Michael , Clegg William , Bogaerts Jonathan , Herrebout Wouter , Allenby Nick , Hall Michael 
Published: April 2022

Abstract
A genomic and bioactivity informed analysis of the metabolome of the extremophile Amycolatopsis sp. DEM30355 has allowed for the discovery and isolation of the polyketide antibiotic tatiomicin. Identification of the biosynthetic gene cluster was confirmed by heterologous expression in Streptomyces coelicolor M1152. Structural elucidation, including absolute stereochemical assignment, was performed using complementary crystallographic, spectroscopic and computational methods. Tatiomicin shows antibiotic activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Cytological profiling experiments suggest a putative antibiotic mode-of-action, involving membrane depolarisation and chromosomal decondensation of the target bacteria.
Gorham-Stout syndrome: a chylothorax disease with massive bony destruction
Authors: Hong Ping-Yang , Zhang Xiao-Bin , Zhao Yi-Lin , Huang Mao-Hong , Zeng Hui-Qing 
Published: April 2022

Abstract
Gorham–Stout syndrome is a sporadic condition characterized by a tumor-like lesion with extensive osteolysis, severe symptoms, and a poor prognosis. Poor prognostic indicators include osteolytic lesions of the spine and pleura effusion. We presented a case in which the condition first manifested itself at the age of 67, with exacerbated shortness of breath. The patient's imaging studies (CT scan, MRI, and PET/CT) revealed osteolytic lesions (the skull, several spines, several ribs, both shoulder blades, and the pelvis). After a tissue biopsy of the spine, postoperative pathology revealed that a portion of the bone had been replaced by lymphatic-derived endothelial cells that stained positive for D2-40. The tests permitted parasitosis, thyroid or parathyroid disease, parasitosis, lymphoma, neoplasia, or an autoimmune problem to be ruled out. On the patient, we performed a superior vena cava angiography. There was an abnormal expansion of the azygos vein into the superior vena cava, as well as local contrast agent retention. The injection of zoledronic acid was used to prevent bone loss. After the therapy, his shortness of breath was greatly reduced. He experienced ongoing shortness of breath alleviation during the 2-month follow-up visit.
Immunogenicity evaluation after BNT162b2 booster vaccination in healthcare workers
Authors: Zurac Sabina , Vladan Cristian , Dinca Octavian , constantin Carolina , Neagu Monica 
Published: April 2022

Abstract
Waning of the immune response upon vaccination in SARS-CoV-2 infection is an important subject of evaluation in this pandemic, mostly in healthcare workers (HCW) that are constantly in contact with infected samples and patients. Therefore, our study aimed to establish the specific humoral response of specific IgG and IgA antibodies upon vaccination, during the second year of pandemic and evaluating the booster shot with the same vaccine type. A group of 103 HCW with documented exposure to the virus were monitored for specific IgG and IgA levels prior to vaccination, after the first vaccination round, during the following 8 months and after the booster shot with the same vaccine type. After 8 months post-vaccination the humoral response in both IgG and IgA decreased, 2.4 times for IgG, and 2.7 times for IgA. Although the antibodies levels significantly decreased, no documented infection was registered in the group. After the booster shot, the entire group, displayed IgG increased levels, immediately after booster followed by the increase in specific IgA. IgG levels post-second round of vaccination are statistically higher compared to the first round, while IgA is restored at the same levels. Within the vaccination or booster routine for a multiple waves’ pandemic that is generating new virus variants, populational immunity remains an important issue for future implementation of prevention/ control measures.
Intelligent 4G Cellular Network Fault Prediction Model
Authors: N Geethu , M. Rajesh 
Published: April 2022

Abstract
From 1G to 5G and beyond cellular network technologies evolve in terms of technical advancement, efficiency, and traffic. Increase in accessibility and data utilization are the notable factors that are causing high network traffic. Higher the connectivity and mobility of cellular devices, higher will be the network traffic. As the transmission rate increases, the possibility of fault occurrence also increases. Continuous monitoring of network parameters and finding the fault on time are the key factors in determining consistency of network. Cellular network which is highly dynamic than usual networks needs intelligent way of fault handling. The monitoring and fault identification human overhead are unpredictable and very high and can cause errors as well. The research in modelling intelligent network fault identification system can simplify human efforts and improve efficiency. The research is on real time data of 4G cellular network including various network parameters like uplink threshold and identify the behaviour of data usual or unusual to predict the fault occurrence. The numerical dataset on various network parameters on usual and unusual behaviours helps to simplify the feature extraction part and to reduce the complexity of the model. The model is finalized based on various machine learning-deep learning model analysis.
A Rapid Tigecycline and Polymyxin B Susceptibility Test for Klebsiella pneumoniae Using Direct-on-Target Micro-droplet Growth Assay
Authors: Xia Zhaoxin , Yang Wensu , Zhu Yi , Xu Huaming , Tang Hao , Lu Guoping , Liu Zhen , Hu Xinyi , Lin Chunhui , Jiang Tong , Shen Jilu 
Published: April 2022

Abstract
Background
Tigecycline (TGC) and polymyxin B (PMB)are important antibiotics for the treatment of multidrug-resistant bacterial infections. However, with the widespread applications, the resistant strains have been isolated. To optimize the use of TGC and PMB, there is an urgent need to develop a rapid detection method for the antibiotics. In recent years, a novel Direct-on-Target Micro-droplet Growth Assay (DOT-MGA) has been developed that can detect antibiotic resistance within hours. The study aims to verify the feasibility and accuracy of DOT-MGA in rapidly identification of TGC and PMB-susceptible and non-susceptible bacteria.
Methods
A total of 67 strains of Klebsiella pneumoniae were collected for DOT-MGA. According to FDA/EUCAST breakpoint concentrations, 6 µL droplets with or without TGC or PMB were added in triplicate into the wells of the MALDI plate with four incubation time points (3 h, 4 h, 6 h, and 8 h). The results were compared with standard databases using Bruker Biotyper software and classified as susceptible and non-susceptible based on the scores.
Results
Compared with the micro-broth dilution method, the DOT-MGA achieved the best detection performance after 4 h of incubation. The results showed that the growth efficiency of TGC and PMB were both 100%, and the classification agreement rates were 98.15% and 96.15%, respectively.
Conclusion
With the 4h incubation time, DOT-MGA can accurately identify the resistance of TGC and PMB, which has good consistency compared with the micro-dilution method. DOT-MGA can provide rapid and reliable drug susceptibility diagnosis, which is of great significance for the clinical anti-infective treatment.
Curcumin piperidone derivatives induce anti-proliferative and anti-migratory effects in LN-18 human glioblastoma cells
Authors: Chan Kok Meng , Razali Nur Syahirah Che , Lam Kok Wai , Rajab Nor Fadilah , Jamal A Rahman A , Kamaluddin Nurul Farahana 
Published: April 2022

Abstract
Curcumin has demonstrated potential cytotoxicity across various cell lines despite its poor bioavailability and rapid metabolism. Therefore, our group have synthesized curcuminoid analogues with piperidone derivatives, FLDP-5 and FLDP-8 to overcome these limitations. In this study, the analogues were assessed on human glioblastoma LN-18 cells in comparison to curcumin. Results from cytotoxicity assessment showed that FLDP-5 and FLDP-8 curcuminoid analogues caused death in LN-18 cells in a concentration-dependent manner after 24-h treatment with much lower IC50 values of 2.5 µM and 4 µM respectively, which were more potent compared to curcumin with IC50 of 31 µM. Moreover, a significant increase (p<0.05) in the level of superoxide anion and hydrogen peroxide upon 2-h and 6-h treatment confirmed the oxidative stress involvement in the cell death process induced by these analogues. These analogues also showed potent anti-migratory effects through inhibition of LN-18 cells’ migration and invasion. In addition, cell cycle analysis showed that these analogues are capable of inducing S-phase cell cycle arrest during the 24-hour treatment, which explained the reduced proliferation indicated by MTT assay. In conclusion, these curcuminoid analogues exhibit potent anti-cancer effects with anti-proliferative and anti-migratory properties towards LN-18 cells as compared to curcumin.
Green Intellectual Capital and Green Supply Chain Performance: Does Big Data Analytics Capabilities matter?
Authors: AL-Khatib Ayman , Shuhaiber Ahmed 
Published: April 2022

Abstract
The current study aimed to identify the impact of the components of green intellectual capital (green human capital, green structural capital and green relational capital) on green supply chain performance in the manufacturing sector in Jordan as well as the moderating role of big data analytics capabilities. Structural equation modelling was used through the Smart-PLS program on a sample of 438 participants. The results showed that each component of the green intellectual capital and big data analytics explains 71.1% of the variance in green supply chain performance and that all components of green intellectual capital have a statistically significant impact on green supply chain performance. The results also revealed that the relationship between green relational capital and green supply chain performance is moderated through big data analytics capabilities. In general, this study made a theoretical and managerial contribution to the supply chain literature.
The presence of EcPV-2 DNA in aborted samples is evidence for vertical transmission of EcPV
Authors: Xie Jinxin , Tong Panpan , Tian Shuyao , Song Xiaozhen , Yang Enhui , Ma Wanpeng , Kuang Ling , Wang Jinquan 
Published: April 2022

Abstract
Nine different species of Equus caballus papillomavirus (EcPV) and three bovine papillomaviruses (BPV) have been reported to infect horses, however, there are so far no describing such infections in China. In our pioneer study with Chinese horses, we first found EcPV-2 in the nasal swabs (4/230, 1.7%) of Yili horses, and semen (3/18, 16.7%) of the Thoroughbred horses. This indicated that EcPV can be indeed hosted by horses in China, and that EcPV-2 might be transmitted though breeding. Further detection of EcPVs and BPVs in the aborted fetal lung tissues of Yili mares, which were originally negative for equid herpesviruses, demonstrated that EcPV-2 was positive in 19 out of 50 samples, thereby indicating this finding is first evidence for vertical transmission of EcPV, simultaneous suggesting that EcPV-2 might be a new pathogen causing of responsible for abortions. Thereafter, the sequence analyses for L1 genes sequences of 26 China’s EcPV-2 were performed which indicated that EcPV-2, that primarily infected the horses in China, shared 98.3%-99.9% nt identity with the already published sequences for EcPV-2. These observations indicated that EcPV-2 identified in the current study were highly similar variants of the previously identified strains of EcPV-2. Phylogenetic analysis based on L1 genes in GenBank showed that EcPV-2, found in the Chinese horses, was closely related to and clustered together with an already known EcPV-2a lineage. Our study provides the early evidence related to EcPV-2 infection in the Chinese horses, and describes the vertical transmission of EcPV for the first time, which can act as a causative agent for Yili horse abortions. Overall, the findings might lay the foundation for a systematic and detailed epidemiological study of this infection in the Chinese horses.
Prognosis of Gestational Trophoblastic Neoplasia with Uterine Arteriovenous Malformation
Authors: Zhou Qing , Liu Yuantao , Lu Xin , Zhang He , Ma Fenghua , Zhang Guofu 
Published: April 2022

Abstract
Objective: This study investigated the prognosis of gestational trophoblastic neoplasia (GTN) with uterine arteriovenous malformation (UAVM) using contrast-enhanced magnetic resonance angiography(CE-MRA) as well as the correlation between UAVM and the prognosis for GTN to determine how to treat these diseases more effectively. Methods: Forty-four patients with GTN at Obstetrics & Gynecology Hospital of Fudan University from December 2015 to December 2020 were selected. Imaging characteristics of conventional magnetic resonance imaging and contrast-enhanced magnetic resonance angiography (CE-MRA) before treatment, treatment methods, and the prognosis were followed-up. Results: A total of 44 cases were included, including five cases of placental site trophoblastic tumor (PSTT) and 39 cases of GTN. There were two cases of PSTT combined with UAVM and 23 cases of GTN combined with UAVM. Thirty-nine cases of GTN were divided into two groups according to the presence or absence of UAVM. Data regarding the β-human chorionic gonadotropin value (<10,000 mIU/mL and ≥10,000 mIU/mL) were evaluated using Chi-square test (P = 0.001); the difference was statistically significant (P < 0.05). There was no significant difference in the International Federation of Gynecology and Obstetrics (FIGO) stage between groups (P > 0.05). The average FIGO scores of the two groups were 4.19 (±3.69) and 6. 70 (±3.39) (P = 0.035); the difference was statistically significant (P < 0.05). Conclusion: The use of CE-MRA is helpful when diagnosing UVAM. The formation of UVAM is related to the prognosis score. The higher the prognosis score, the greater the possibility of UAVM.
Automated external defibrillators and basic life support practices in secondary schools: A nationwide study
Authors: Abela Mark , Grech Victor , Sammut Mark Adrian 
Published: April 2022

Abstract
AimCardiac arrest prevention in schools has recently gained momentum. The survival benefit in schools who have access to defibrillators is clear, with far better survival outcomes in children or adults who sustain a cardiac arrest on school grounds. The main objectives of this study were to assess sudden cardiac arrest (SCA) prevention in Maltese schools, specifically the availability of defibrillators and staff competence in delivering resuscitation.Methodology and resultsAn online based questionnaire was distributed to all secondary schools across the Maltese archipelago. Data was collected, tabulated, and analysed using SPSS V.23. Most schools (n=40, 74.1%) completed the questionnaire. Two schools documented a SCA in the past 10 years. 87.5% agreed that SCA prevention is an important health topic. Most have a defibrillator on the premises (n=37, 92.5%). Only 1 defibrillator is usually available (n=27, 75.0%). Despite the majority claiming its ease of accessibility (n=35, 97.2%), most where not available on every floor (n=37, 97.2%). Only a third were close to a sporting facility (n=11, 30.6%). Schools do not organise regular resuscitation courses (n=21, 58.3%), with 8 schools having five or more certified staff members (23.5%). The number of defibrillators did not influence the frequency of CPR courses at school (p=0.607) and there was no association with the number of certified individuals (p=0.860). ConclusionDefibrillators are not readily available at secondary schools and are often installed in low risk areas. Most schools have only one staff member certified in resuscitation. These factors should be addressed with urgency.
Performance Evaluation and GGEbiplot Analysis of Sesame (Sesamum indicum L.) Genotypes in Eastern Ethiopia
Authors: Hassen Mohammed 
Published: April 2022

Abstract
Background
Sesame is an oil, a food source and cash crop. Even though, there is a lot of potential for sesame production in Ethiopia, the average seed yield of sesame is very low due to a lack of high yielder improved sesame variety/ies. As a result, the goals of this study were to assess the performance of sesame genotypes and GGEbiplot analysis.
Materials and Methods
in a randomized complete block design with three replications, fifteen sesame genotypes, including check (Adi), were tested during the main cropping season (2014, 2015 and 2016) at three sesame growing locations: Werer, Bonta (Arage), and Miesso.
Results and Discussion
Serkamo white (G12) and Acc-44(1) (G14) performed better than the other genotypes. As a result, its main advantages over the other genotypes tested were its higher grain yield and white seed color.
Conclusion
Serkamo white (G12)genotype are expected to grasp high external market preferences and prices due to their seed yield and white seed color, contributing to the future sesame export market.