bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying Youth with Anxiety Disorders in Pediatric Primary Care Setting: A Preliminary Report from Thailand
Authors: Ularntinon Sirirat , Nithiuthai Jinjutha 
Published: March 2022

Abstract
Background: Non-specific somatic symptoms are common chief complaints among the youths who have anxiety disorders, particularly in non-Western countries where childhood mental health needs are under-recognized. Screening for the youths at risk of anxiety disorders in pediatric medical setting, then can be an ample opportunity to identify this most prevalent but under-diagnosed mental health problem. Therefore, this study aims to determine the possibility of identifying the youths at risk of having anxiety disorders who visited a pediatric primary care clinic for the examination of physical symptoms in Thailand.Methods: The Screen for Child Anxiety and Related Emotional Disorders (SCARED - Thai Version), including youth self-report and parent forms, were completed by 92 pairs of youths andtheir parents. Data regarding associated factors, clinical characteristics, and general health status in the past year were obtained. Results: Anxiety disorder symptoms above the threshold for clinical diagnosis of the SCARED were identified in 39% of participants. Clinical variables associated with significantly elevated anxiety symptoms included female gender, having non-specific somatic pain as main complaints, and a number of medical visits greater than 6 times in the past year.Conclusions: Anxiety disorder in youths is frequently under-diagnosed and un-treated, hence, becoming a hidden burden in pediatric medical setting in non-Western countries where mental health movement is still evolving. Enhancing awareness of the possibility of anxiety disorder in the youths presenting with unexplained physical complaints is a crucial step toward reducing this load of unnecessary medical health care utilization and optimizing long-term outcomes of the affected youths.
Level IV neck dissection in cN0 HPV-negative oropharyngeal squamous cell carcinoma: A retrospective cohort study
Authors: Huo Zirong , Fu Shuiting , Ma Chunyue , Sheng Surui 
Published: March 2022

Abstract
Background: As opposed to observation of the neck, elective neck dissection has a survival benefit for cN0 oropharyngeal squamous cell carcinoma (OPSCC). However, there are limited date on level IV neck dissection in human papillomavirus (HPV)-negative OPSCC because most earlier studies did not stratify by P16 or HPV status. Thus, whether to exclude level IV from selective dissection (SND) of cN0 HPV-negative OPSCC remains controversial. Methods: In this single-center retrospective cohort study, disease-free survival (DFS) was estimated as the primary endpoint for 124 cN0 HPV-negative OPSCC patients who received SND of levels I-III (Group A) and I-IV (Group B). Overall survival (OS) and disease-specific survival (DSS) were considered secondary endpoints.Results: For the entire cohort, the 5-year DFS rates of Groups A and B were 55.0% and 60.1%, respectively. Five-year OS rates were 58.9% and 61.5%, and 5-year DSS rates were 74.0% and 64.8%, respectively. Group B did not show higher 5-year DFS, OS, or DSS than Group A.Conclusions: This retrospective cohort study validated that in cN0 HPV-negative OPSCC, SND including level IV does not have substantial benefits regarding DFS, OS or DSS.
Development of SSR markers and genetic diversity evaluation of Mycocentrospora acerina causing round spot of Panax notoginseng in Yunan province, China
Authors: He Xiahong , Wang Huiling , Yang Kuan , Guo Liwei , Luo Lifen , He Chi , Li Xiang , Liu Yixiang , Huang Huichuan , Yang Min , Zhu Shusheng , Zhu Youyong 
Published: March 2022

Abstract

Background: Sanqi round spot, which is caused by Mycocentrospora acerina, is a destructive disease limits the production of Panax notoginseng in Yunnan province of China. However, the disease has not been studied comprehensively. Results: In the current study, we identify M. acerina polymorphic microsatellite markers using CERVUS 3.0 and compare the genetic diversity of its isolates from P. notoginseng round spot using Simple Sequence Repeat (SSR) markers and polyacrylamide gel electrophoresis. Thirty-two SSR markers with good polymorphism were developed using MISA and CERVUS 3.0. The genetic diversity of 187 M. acerina isolates were evaluated using 14 representative SSR primers, and the polymorphic information content values of 14 sites ranged from 0.813 to 0.946, with a total of 264 alleles detected at 14 microsatellite loci. The average expected heterozygosity was 0.8967. Conclusion: 14 SSR primers of M.acerina can be used in diversity analysis and identification of M. acerina and its closely related species. Genetic diversity of M. acerina in Yunnan province does not reflect geographic specificity.
The Applicability of eVTOLs in Emergency Medical Care in Japan
Authors: Nakamoto Aki , Mihara Yusuke , Motomura Tomokazu , Matsumoto Hisashi , Nakano Masaru 
Published: March 2022

Abstract
Background: The present study aims to elucidate the applicability of electric vertical takeoff and landing (eVTOL) aircraft that dispatch only a doctor to provide a solution to the operational challenges of utilizing a helicopter to transport a doctor to the patient/s, with such physician-staffed emergency medical helicopters being known as doctor heli (DH), in Japan.Methods: This study conducted interviews with 17 parties related to DHs in five prefectures in Japan to depict challenges of DHs and eVTOL requirements. Subsequently, this study analyzed the Hokusoh DH flight data, as an example, in terms of cases for which flight doctors consider condition assessment and initial treatment provision by a doctor would be particularly effective, to assess the hypothesis that a two-seater is applicable for emergency medical care (EMS) and that eVTOLs help reduce duplicate dispatch requests for DHs as well as the percentage and delayed dispatch time of duplicate requests.Results: Challenges of DHs and eVTOL requirements were identified and classified into six major categories. Data analysis results indicated that two-seater eVTOLs would be particularly effective for trauma, cardiac disease, brain disease cases, and pediatric patient cases and help solve duplicate requests.Conclusions: Two-seater eVTOLs are likely applicable in EMS in Japan.
Assessment of Type I Interferon Signatures in Undifferentiated Inflammatory Diseases: A Japanese Multicenter Experience
Authors: Miyamoto Takayuki , Honda Yoshitaka , Izawa Kazushi , Kanazawa Nobuo , Kadowaki Saori , Ohnishi Hidenori , Fujimoto Masakazu , Kambe Naotomo , Kase Naoya , Shiba Takeshi , Nakagishi Yasuo , Akizuki Shuji , Murakami Kosaku , Bamba Masahiro , Nishida Yutaka , Inui Ayano , Fujisawa Tomoo , Nishida Daisuke , Iwata Naomi , Otsubo Yoshikazu , Ishimori Shingo , Nishikori Momoko , Tanizawa Kiminobu , Nakamura Tomoyuki , Ueda Takeshi , Ohwada Yoko , Tsuyusaki Yu , Shimizu Masaki , Ebato Takasuke , Iwao Kousho , Kubo Akiharu , Kawai Toshinao , Matsubayashi Tadashi , Miyazaki Tatsuhiko , Kanayama Tomohiro , Isa-Nishitani Masahiko , Nihira Hiroshi , Abe Junya , Tanaka Takayuki , Hiejima Eitaro , Okada Satoshi , Ohara Osamu , Saito Megumu K , Takita Junko , Nishikomori Ryuta , Yasumi Takahiro 
Published: March 2022

Abstract
PurposeUpregulation of type I interferon (IFN) signaling has been increasingly detected in inflammatory diseases. Recently, upregulated IFN signature has been suggested as a potential biomarker to identify IFN-driven inflammatory diseases. Yet, it remains unclear to what extent type Ⅰ IFN is involved in the pathogenesis of undifferentiated inflammatory diseases. This study aimed to quantify the type Ⅰ IFN signature in clinically undiagnosed patients and assess clinical characteristics in those with a high IFN signature. Methods A type Ⅰ IFN signature was measured in patients’ whole blood cells. Clinical and biological data were collected retrospectively, and an intensive genetic analysis was performed in undiagnosed patients with a high IFN signature.ResultsA total of 113 samples from 94 patients with inflammatory diseases, including 37 undiagnosed cases, were analyzed. Increased IFN signaling was observed in 19 undiagnosed patients, with ten exhibiting clinical features commonly found in type Ⅰ interferonopathies. Skin manifestations, observed in eight patients, were macroscopically and histologically similar to those found in proteasome-associated autoinflammatory syndrome. Genetic analysis identified novel mutations in the PSMB8 gene of one patient, and rare variants of unknown significance, in genes linked to type Ⅰ IFN signaling, in four patients. A JAK inhibitor effectively treated the patient with the PSMB8 mutations. Patients with clinically quiescent idiopathic pulmonary hemosiderosis and A20 haploinsufficiency showed enhanced IFN signaling.ConclusionsHalf of the patients examined in this study, with undifferentiated inflammatory diseases, clinically quiescent A20 haploinsufficiency, or idiopathic pulmonary hemosiderosis, had an elevated type Ⅰ IFN signature.
Accuracy of SCORTEN in predicting mortality
Authors: Strużyna Jerzy , Surowiecka Agnieszka , Korzeniowski Tomasz , Korulczyk Patrycja , Drozd Lukasz , Stachura Aldona , Torres Kamil , Krajewski Andrzej 
Published: March 2022

Abstract
BackgroundTEN patients require multi-directional and multi-disciplinary treatment. In most cases, they are hospitalised at intensive care units and require multi-directional, burn-complication preventive care. Choosing the most appropriate treatment option might be troublesome even when predicting scores are used. SCORTEN is the most renowned prognostic score for TEN patients, however, there are some data indicating that the accuracy of this test may be limited. The credibility of not just the predicted mortality risk, but also componential laboratory results and clinical features subject to debate. The aim of this study was to evaluate the efficacy and credibility of SCORTEN in clinical practice, on proprietary material. Methods: A retrospective analysis of 35 patients with diagnosed in histopathology TEN was performed. The inclusion criteria were as follows: day of submission before 5th day from the onset of the symptoms, full protocol of plasmaphereses and IVIGs according to our scheme.Results:The sensitivity of SCORTEN for the analysed cohort was 100%, with a specificity of 24%. The estimated death was 41,9%, while the actual death rates were 12,5%. Our protocol improved the survival, OR=26,57, RR=6,34, p=0,022. Decrease in mortality was caused by a combined treatment protocol we use- plasmaphereses with IVIGs. No independent risk factor was significant in death evaluation. Conclusions:Our data suggest that the scoring system for predicting death among TEN patients are reliable when they are high. New prognostic factors should be found to improve the evaluation of patients with low SCORTEN.
Obtaining A Unified Picture of Heterogeneous and Homogeneous Crystallization with Kinetic Transition Rate
Authors: Chen Zhen , Xu Lei 
Published: March 2022

Abstract
Heterogeneous and homogeneous crystallization exhibit distinct phase transition kinetics. However, due to the difficulty of realizing both heterogeneous and homogeneous crystallization under an identical thermodynamic condition, an independent comparison of the two remains lacking. In this work, we experimentally realize a continuous tuning from heterogeneous to homogeneous crystallization under an identical thermodynamic condition, capture the entire colloidal crystallization process of each particle, and discover a universal picture of the two modes. In the heterogeneous crystallization regime, we reveal an unexpected variation of critical nucleus size with boundary disorderness instead of contact angle, which violates the classical nucleation theory but enables the system tuning. Moreover, analogous to reaction rates in chemical reactions, we propose and measure the kinetic transition rates of crystallization, which quantify the transition probabilities between any two intermediate structures. To our surprise, regardless of heterogeneous or homogeneous crystallization, all 42 kinetic transition rates fall onto universal master curves, which unifies the two distinct crystallization modes into a universal picture.
P-selectin in pregnant women with vein thrombosis and compare the predictive value of this biomarker with Wells criteria
Authors: tabrizian shervin , ghobadi hasan , khorrami yadollah , rostamnejhad masoomeh , safarzadeh elham , matin somaieh 
Published: March 2022

Abstract
Background: The diagnosis of venous thromboembolism (VTE) during pregnancy is a challenging task. Due to its naturally high level during pregnancy, D-Dimer concentration is not reliable diagnostic. P-selectin is another diagnostic biomarker that can aid the diagnosis of VTE. In the present study, an attempt was made to determine the relationship between P-selectin and acute VTE in pregnant women and compare it’s predictive value with Wells criteria.Materials and methods: In this case-control study, 29 pregnant women with pulmonary thromboembolism (PTE), 33 pregnant women with deep vein thrombosis (DVT), and 32 matched healthy pregnant women were investigated. After obtaining informed written consent, 3 cc of venous blood sample was taken from each of the participants. The samples were then assessed for P-selectin and D-Dimer concentrations via the use of ELISA tests. Finally, statistical analyses were performed. Findings: Significant differences were observed between all of the groups under investigation in terms of both mean P-selectin and mean D-Dimer concentrations (P<0.05). The mean P-selectin concentration in patients with high Wells score was significantly higher than that of the patients with moderate and low Wells score (P<0.05). Moreover, week positive correlation was observed between P-selectin and D-Dimer concentrations (r=0.3, P=0.003). Logistic regression also revealed that both P-selectin and D-dimer were predictive factors of thrombosis in pregnant women. Conclusion: The increase in P-selectin concentration during pregnancy is associated with high incidence of VTE. Compared with D-Dimer, P-selectin is a predictor of thrombosis, especially in patients with high clinical probability based on Wells score.
A Reexamination of How National Culture Influences Environmental Performance: Based on Neo-Configurational Perspective
Authors: Xu Ting , Chen Di , Lv Zhike 
Published: March 2022

Abstract
The inconsistencies and conflicts in the relationship between national culture and environmental performance imply the need for more fine-grained research. Our study advanced existing research by identifying the configurational effect of the six cultural dimensions that lead to high or low environmental performance with the support of the fuzzy-set Qualitative Comparative Analysis (fsQCA). Our results demonstrate that there is no national recognized as a necessary condition for high environmental performance, but high power distance and collectivism are identified as necessary conditions for low environmental performance. And we also summarize four configurations leading to high environmental performance and one configuration leading to low environmental performance. This study contributes to the field of cultural factors and environmental performance from the perspective of method and content.
Birt-Hogg-Dubé Syndrome Encountered At Rare Lung Disease Clinic In Anhui Province, China
Authors: Zhang Guofeng , Liu Jinli , Wang Yushuo , Wang Yue , Jiang Xianliang , Peng Yan , Xiao Jun , Wei Wei , Shen Bing , Yi Long , Ryu Jay H. , Hu Xiaowen 
Published: March 2022

Abstract
Background: Diagnosis of rare diseases remains a challenge in China. We describe our experience with Birt-Hogg-Dubé syndrome (BHDS) encountered at a Rare Lung Disease Clinic recently established in China.Methods: After the first patient with BHDS was recognized in 2017, a Rare Lung Disease Clinic with a multidisciplinary team of specialists was established. We retrospectively analyzed the data of consecutive patients with BHDS encountered from inception to December 2021.Results: There were 1, 1, 15, 12 and 21 cases with BHDS diagnosed from year 2017 to 2021, respectively. All 50 patients (34 women) were of Han race with a mean age of 47.3 years. The common manifestations were pulmonary cysts (98%), pneumothorax (54%) and skin lesions (68%). Renal cancer was detected in two patients and renal angiomyolipoma in four other patients. The main presentations leading to diagnosis were pneumothorax (42%), family screening (36%) and lung cysts identified on radiologic imaging (20%). The average delay in diagnosis was 8.3 years, and 4.7 years in patients with only pulmonary cysts. The most frequent pathogenic variant was c.1285del/dup on exon 11 (23%) among 44 patients confirmed by genetic testing. Renal cancer has not been found on follow-up surveillance thus far.Conclusions: There has been increasing number of patients with BHDS recognized in China, facilitated by establishment of a Rare Lung Disease Clinic. Pulmonary cysts and pneumothorax were commonly encountered features, but skin lesions appeared to be more prevalent in Chinese subjects than previously reported in other Asian countries.
Introduced Galliforms As Seed Predators And Dispersers In Hawaiian Forests
Authors: Case Samuel , Postelli Katherine , Drake Donald R. , Vizentin-Bugoni Jeferson , Foster Jeffrey T. , Sperry Jinelle H. , Kelley J. Patrick , Tarwater Corey E. 
Published: March 2022

Abstract
In altered communities, novel species’ interactions may critically impact ecosystem functioning. One key ecosystem process, seed dispersal, often requires mutualistic interactions between frugivores and fruiting plants, and functional traits, such as seed width, may affect interaction outcomes. Forests of the Hawaiian Islands have experienced high species turnover, and introduced galliforms, the largest of the extant avian frugivores, consume fruit from both native and non-native plants. We investigated the impact of two galliform species on seed dispersal processes in Hawaiian forests. Using captive Kalij Pheasants (Lophura leucomelanos) and Erckel’s Francolins (Pternistis erckelii), we measured the probability of seed survival during gut passage and seed germination following gut passage. We also examined which seeds are being dispersed in forests on the islands of O‘ahu and Hawai‘i. We found that galliforms are major seed predators for both native and non-native plants, with less than 5% of seeds surviving gut passage for all plants tested and in both bird species. Gut passage by Kalij Pheasants significantly reduced the probability of seeds germinating, especially for the native plants. Further, larger-seeded plants were both less likely to survive gut passage and to germinate. In the wild, galliforms dispersed native and non-native seeds at similar rates. Overall, our results suggest the introduced galliforms are a double-edged sword in conservation efforts; they may help reduce the spread of non-native plants, but they also reduce seed dispersal of native plants. Broadly, we show mutualism breakdown may occur following high species turnover, and that functional traits can be useful for predicting outcomes from novel species’ interactions.
Impairment Strained Analytical Modeling Evaluation and Cross-talk Analysis of Symmetric and Coexistent Channels for Extended Class-1 NG-PON2 Access Network
Authors: Pagare Rajendraprasad , Mishra Abhilasha , Kumar Santosh 
Published: March 2022

Abstract
The analytical modeling for channel linear and non-linear impairments (LNI) and simulative analysis of extended power budget class-1 i.e. E1-class of next generation passive optic network-2 (NG-PON2) delivering symmetric 2.5 point-to-multi point (PtM) representing time and wavelength division multiplexing (TWDM) XGS-PON along with 10 Gbps point-to-point (PtP) wavelength division multiplexing (WDM) symmetric and coexistent channels in worst-case scenario is presented in the paper. Channel modelling of LNI is carried out under the incremental and aggregate strain of estimated chromatic dispersion CD, selfphase modulation (SPM), cross-phase modulation (XPM) of single mode fiber (SMF) channel deployed in optical distributing network (ODN) between 20 – 50 km link lengths. Downlink (D/L) and uplink (U/L) ODN is optimized to PTODN = 7.1 dBm and 4.09 dBm respectively and corresponding channel imparities including Kerr parameter γ, corresponding SPM, XPM, CD, four-wave mixing (FWM) analysis and corresponding component power and efficiency, interchange crosstalk (Cc) attracting power penalties (Pc) are estimated and incorporated in the simulation for the real response of lossy SMF channel. Further, splitter power budget (SP) and slitter configuration for respective PtM and PtP D/L channels are estimated under the aggregate impact of CD, SPM, XPM and FWM. Analytical modeling of LNI and simulative analysis has confirmed the configuration delivered rise in receiver sensitivity (Rxs) of -39.75/-33.45 dBm and -29/-35.34 dBm for D/L and U/L channels respectively. The estimated power of FWM element is between 1.34x10-52 to 2.15x10-53 and 3.87x10-52 to 2.41x10-51 contributing crosstalk between channels (Cc) of -31.97/-30.12 dB for down/up spectrum under the impact of SPM and XPM respectively accommodating splitter configuration of 768 at 40 km.
Wellness on Wheels (WoW): Iterative evaluation and refinement of mobile computer-assisted chest x-ray screening for TB improves efficiency, yield, and outcomes in Nigeria
Authors: Mitchell Ellen , Abdur-Razzaq Hussien , Anyebe Victor , Lawanson Adebola , Onyemaechi Simeon , Chukwueme Nkemdilim , Scholten Jerod , Nongo Debby , Ogbudebe Chidubem , Aboki Danjuma , Dimkpa Chimezie , Egbule Daniel , Nsa Bassey , Eneogu Rupert , Grinten Emmy van der , Useni Sani , Festus O. Soyinka , Nwadike Peter , Gidado Mustapha , Ubochioma Emperor 
Published: March 2022

Abstract
Background: Wellness on Wheels (WoW) is a model of mobile systematic TB screening of high-risk populations combining digital chest radiography with computer-aided automated interpretation and chronic cough screening to identify presumptive TB in communities, health facilities and prisons in Nigeria. Understanding how models are designed and refined over time helps others to anticipate technical and political challenges, replicate successful strategies, and avoid common mistakes.Methods: We piloted and refined approaches in phased evaluations, recalibrating CAD4TB thresholds to balance TB yield and feasibility. Iterative data monitoring of screening volumes, risk mix, number needed to screen (NNS), number needed to test (NNT), sample loss, TB treatment initiation and outcomes. Risk factors for loss along the diagnostic cascade were identified and mitigation plans were implemented. Participants with high likelihood on CAD4TB (≥80) who tested negative on a single spot GeneXpert were followed-up.Results: Gradual improvements included: achieving screening targets (64.0% to 70.5%), risk group inclusion (91.5% to 92.9%), on-site sample processing (84.3% to 86.1%), treatment initiation (86.7% to 90.8%), treatment success (70.6% to 83.2%), and NNT (8.2 to 7.6). However, expectoration by asymptomatic presumptive participants (≈85%) and HIV testing coverage (64.9%) remained suboptimal.Conclusion: Mobile computer-assisted digital chest x-ray and chronic cough screening with GeneXpert MTB/RIF testing is feasible, acceptable, efficient and high-yield when highest risk groups and key stakeholders are engaged, and operations evolve in real time to fix problems. CAD4TB scores should be used to identify people who need clinical diagnosis and/or longer-term follow-up for progression to TB disease.