bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ancestral area analyses reveal Pleistocene‐influenced evolution in a clade of coastal plain endemic plants
Authors: Naranjo Andre A. , Folk Ryan A. , Gitzendanner Matthew A. , Soltis Douglas E. , Soltis Pamela S. 
Published: December 2022

AbstractAimThe North American Coastal Plain is currently recognized as a global biodiversity hotspot. However, the mechanisms driving high levels of species richness in a region with relatively low topographic relief and homogeneous climate are unclear. We investigated the evolutionary processes driving ancestral area evolution and diversification in a biodiversity hotspot from both a systematic and biogeographical context using a clade endemic to the hotspot.LocationNorth American Coastal Plain.TaxonThe Scrub Mint clade (SMC) comprises Dicerandra, Conradina, Piloblephis, Stachydeoma and four species of Clinopodium (Mentheae; Lamiaceae), almost all of which are endemic to the North American Coastal Plain.MethodsWe generated a dated phylogeny using a target enrichment/capture dataset and then calculated ancestral area using biogeographical models. We uncovered neo‐ and palaeo‐endemism hotspots and inferred ancestral potential ranges at each node based on ancestral niche reconstructions and palaeoclimatic data to understand the geographical range evolution of subclades.ResultsAncestral area for the SMC was inferred to be the Florida Panhandle/Apalachicola River basin. A diversification event likely happened around the mid‐Pleistocene Transition. Endemism hotspots were recovered in NE Florida, the Atlantic Coastal Ridge, and along the Lake Wales Ridge. Reconstructions of potential ranges support biogeographical findings, with the ancestor of the SMC likely located in the vicinity of the northeastern Gulf Coast during interglacial and glacial periods.Main ConclusionsThe timing of diversification events and colonization of new areas by ancestors of the SMC are consistent with the timing of major geological events in the region. The presence of multiple types of endemism highlights the complexity of evolutionary and ecological processes that foster the large number of endemic taxa found in this region. Efforts to identify hotspots in this region will be critical to preserving the remaining pockets of biodiversity threatened by global change.
Low voltage area guided substrate modification in nonparoxysmal atrial fibrillation: A systematic review and meta‐analysis
Authors: Moustafa Abdelmoniem , Karim Saima , Kahaly Omar , Elzanaty Ahmed , Meenakshisundaram Chandramohan , Abi‐Saleh Bernard , Eltahawy Ehab , Chacko Paul 
Published: December 2022

AbstractBackgroundLow voltage areas (LVAs) on left atrial (LA) bipolar voltage mapping correlate with areas of fibrosis. LVAs guided substrate modification was hypothesized to improve the success rate of atrial fibrillation (AF) ablation particularly in nonparoxysmal AF population. However, randomized controlled trials (RCTs) and observational studies yielded mixed results.MethodsThe databases of Pubmed, EMBASE and Cochrane Central databases were searched from inception to August 2022. Relevant studies comparing LVA guided substrate modification (LVA ablation) versus conventional AF ablation (non LVA ablation) in patients with nonparoxysmal AF were identified and a meta‐analysis was performed (Graphical Abstract image). The efficacy endpoints of interest were recurrence of AF and the need for repeat ablation at 1‐year. The safety endpoint of interest was adverse events for both groups. Procedure related endpoints included total procedure time and fluoroscopy time.ResultsA total of 11 studies with 1597 patients were included. A significant reduction in AF recurrence at 1‐year was observed in LVA ablation versus non LVA ablation group (risk ratio [RR] 0.63 (27% vs. 36%),95% confidence interval [CI] 0.48–0.62, p < .001]. Also, redo ablation was significantly lower in LVA ablation group (RR 0.52[18% vs. 26.7%], 95% CI 0.38–0.69, p < .00133). No difference was found in the overall adverse event (RR 0.7 [4.3% vs. 5.4%], 95% CI 0.36–1.35, p = .29).ConclusionLVA guided substrate modification provides significant reduction in recurrence of all atrial arrhythmias at 1‐year compared with non LVA approaches in persistent and longstanding persistent AF population without increase in adverse events.
Predictors of response to axicabtagene‐ciloleucel CAR T cells in aggressive B cell lymphomas: A real‐world study
Authors: Iovino Lorenzo , Wu Qian Vicky , Voutsinas Jenna , Panaite Lorena , Mullane Erin , Lynch Ryan C. , Ujjani Chaitra , Smith Stephen D. , Gopal Ajay K. , Till Brian G. , Milano Filippo , Chow Victor , Gauthier Jordan , Turtle Cameron J. , Maloney David G. , Shadman Mazyar 
Published: December 2022

AbstractChimeric antigen receptor T‐cell (CAR T) therapy has shown promising efficacy in relapsed and refractory diffuse large B cell lymphoma (DLBCL). While most patients undergo CAR T infusion with active disease, the impact of some clinical variables, such as responsiveness to the pre‐CAR T chemotherapy on the response to CAR T, is unknown. In this single‐institution study, we studied the impact of several pre‐CAR T variables on the post‐CAR outcomes. Sixty patients underwent apheresis for axicabtagene‐ciloleucel (axi‐cel) and 42 of them (70.0%) had primary refractory disease. Bridging therapy between apheresis and lymphodepletion was given in 34 patients (56.7%). After axi‐cel, the overall response rate was 63.3%. Responsiveness to the immediate pre‐CAR T therapy did not show a significant association with response to axi‐cel, progression‐free (PFS) or overall (OS) survival. Multivariable analysis determined that bulky disease before lymphodepletion was independently associated with inferior outcomes, and patients that presented with high‐burden disease unresponsive to immediate pre‐CAR T therapy had a dismal outcome. This data supports proceeding with treatment in CAR T candidates regardless of their response to immediate pre‐CAR T therapy. Interim therapeutic interventions should be considered in patients who have known risk factors for poor outcomes (bulky disease, high LDH).
Antiparasitic effect of copper alloy mesh on tomont stage of Cryptocaryon irritans in aquaculture
Authors: Zahid Aysha , Yu Youbin , Bushra  , Zhou Suming , Xie Xiao , Yin Fei 
Published: December 2022

AbstractCopper alloy sheets have been shown to prevent cryptocaryoniasis. Therefore, we studied the potential efficiency of copper alloy mesh (CAM) in aquaculture tanks to prevent cryptocaryoniasis outbreaks. The effectivenesses of CAM against the tomont stage of Cryptocaryon irritans and in protecting fish from cryptocaryoniasis were tested both in vitro and in vivo. The mortality rate of C. irritans tomonts increased as the contact time with CAM rose and peaked at 70 min (100% of mortality). Morphological changes were observed such as the shrinking of the protoplasm of the treated tomonts, resulting in a larger gap between the cytoplasm and the cyst wall. Mitochondrial dysfunction due to shrinkage in the inner portion, outer and inner mitochondrial membrane damage and cytoplasmic vacuolation was revealed by ultrastructural analysis. The use of CAM effectively preventing reinfection was also provided. In comparison with group B (infected fish without CAM), both groups A (uninfected fish as a control group) and C (infected fish treated with CAM) had a 100% survival rate until the end of the trial. CAM has the same anticryptocaryoniasis effect as copper alloy sheets but is more advantageous due to its lightweight, reduced labor cost and lower purchase cost. It is noticeable that CAM exposure also prevents the excessive accumulation of copper ions in aquaculture sea water.
Liquidity shocks and intraday price reaction
Authors: Chen Tao 
Published: December 2022

AbstractUsing a global sample of high‐frequency data, I investigate how liquidity shocks affect intraday price movements. I find a negative association between liquidity shocks and price impact. This finding remains robust after considering the exogeneity of liquidity shocks, using alternative windows to measure liquidity shocks, and controlling for volume shocks and volatility shocks. Additional tests show that the documented relation stems from idiosyncratic shocks and sell‐order shocks. Moreover, I find that liquidity shocks are likely driven by uninformed traders. My evidence suggests that the market requires 30 min to accomplish price adjustments when meeting liquidity shocks.
From molecular basics to agronomic benefits: Insights into noncoding RNA‐mediated gene regulation in plants
Authors: Wang Yuqiu , Deng Xing Wang , Zhu Danmeng 
Published: December 2022

AbstractThe development of plants is largely dependent on their growth environment. To better adapt to a particular habitat, plants have evolved various subtle regulatory mechanisms for altering gene expression. Non
coding
RNAs (ncRNAs) constitute a major portion of the transcriptomes of eukaryotes. Various ncRNAs have been recognized as important regulators of the expression of genes involved in essential biological processes throughout the whole life cycles of plants. In this review, we summarize the current understanding of the biogenesis and contributions of
small
nucle
olar RNA (snoRNA)‐ and regulatory
long
non
coding RNA (lncRNA)‐mediated gene regulation in plant development and environmental responses. Many regulatory ncRNAs appear to be associated with increased yield, quality and disease resistance of various species and cultivars. These ncRNAs may potentially be used as genetic resources for improving agronomic traits and for molecular breeding. The challenges in understanding plant ncRNA biology and the possibilities to make better use of these valuable gene resources in the future are discussed in this review.
Third‐generation sequencing‐selected Scardovia wiggsiae promotes periodontitis progression in mice
Authors: Chen Yi‐Wen , Wu Guan‐Hua , Lee Bor‐Shiunn , Liu Chung‐Te , Li Huei‐Ying , Cheng Shih‐Jung , Kuo Wei‐Ting , Jeng Jiiang‐Huei , Chang Po‐Chun , Lin Chun‐Pin , Chou Han‐Yi E. , Hou Hsin‐Han 
Published: December 2022

AbstractBackgroundsPeriodontitis is an oral‐bacteria‐directed disease that occurs worldwide. Currently, periodontal pathogens are mostly determined using traditional culture techniques, next‐generation sequencing, and microbiological screening system. In addition to the well‐known and cultivatable periodontal bacteria, we aimed to discover a novel periodontal pathogen by using DNA sequencing and investigate its role in the progression of periodontitis.ObjectiveThis study identified pathogens from subgingival dental plaque in patients with periodontitis by using the Oxford Nanopore Technology (ONT) third‐generation sequencing system and validated the impact of selected pathogen in periodontitis progression by ligature‐implanted mice.MethodsTwenty‐five patients with periodontitis and 25 healthy controls were recruited in this study. Subgingival plaque samples were collected for metagenomic analysis. The ONT third‐generation sequencing system was used to confirm the dominant bacteria. A mouse model with ligature implantation and bacterial injection verified the pathogenesis of periodontitis. Neutrophil infiltration and osteoclast activity were evaluated using immunohistochemistry and tartrate‐resistant acid phosphatase assays in periodontal tissue. Gingival inflammation was evaluated using pro‐inflammatory cytokines in gingival crevicular fluids. Alveolar bone destruction in the mice was evaluated using micro‐computed tomography and hematoxylin and eosin staining.ResultsScardovia wiggsiae (S. wiggsiae) was dominant in the subgingival plaque of the patients with periodontitis. S. wiggsiae significantly deteriorated ligature‐induced neutrophil infiltration, osteoclast activation, alveolar bone destruction, and the secretion of interleukin‐6, monocyte chemoattractant protein‐1, and tumor necrosis factor‐α in the mouse model.ConclusionOur metagenome results suggested that S. wiggsiae is a dominant flora in patients with periodontitis. In mice, the induction of neutrophil infiltration, proinflammatory cytokine secretion, osteoclast activation, and alveolar bone destruction further verified the pathogenic role of S. wiggsiae in the progress of periodontitis. Future studies investigating the metabolic interactions between S. wiggsiae and other periodontopathic bacteria are warranted.
Powerless, Stupefied, and Repressed Actors Cannot Challenge Climate Change: Real Helplessness as a Barrier Between Environmental Concern and Action
Authors: Gunderson Ryan 
Published: December 2022

AbstractThere is a gap between concern about environmental degradation such as climate change and effective action taken against the forces that drive degradation. This paper argues that real helplessness, a social condition producing powerless, stupefied, and repressed actors, is a fortified barrier between climate concern and effective climate action. Political‐economic analysis has theoretical and methodological implications for environmental social science and helps explain a current conundrum in critical sociology: Why are alternatives to a system that drives climate change and other catastrophic risks still seen as unrealistic? We suffer from a political‐economic system impervious to transformation before we suffer from a lack of alternative ideas.
Investigating Orthographic Versus Auditory Cross‐Situational Word Learning With Online and Laboratory‐Based Testing
Authors: Escudero Paola , Smit Eline A. , Angwin Anthony J. 
Published: December 2022

AbstractResearch has shown that novel words can be learned through the mechanism of statistical or cross‐situational word learning (CSWL). So far, CSWL studies using adult populations have focused on the presentation of spoken words. However, words can also be learned through their written form. This study compared auditory and orthographic presentations of novel words with different degrees of phonological overlap using CSWL in a laboratory‐based and an online‐based approach. In our analyses, we first compared accuracy across modalities, with our findings showing more accurate recognition performance for CSWL when novel words were presented through their written forms (orthographic condition) rather than through their spoken forms (auditory condition). Bayesian modeling suggested that accuracy for the orthographic condition was higher in the laboratory compared to online, whereas performance in the auditory condition was similar across both experiments. We discuss the implications of our findings for presentation modality and the benefits of our online testing protocol for future research.
Retracted: Features of the Development of Future Teachers‐Psychologists' Ability to a Narrative
Authors: Mailybayeva Zhazira , Yermentayeva Ardakh R. , Aikinbayeva Gulden K. , Akhmadiyeva Zhanna K. , Bekova Zhanat K. 
Published: December 2022

Abstract
Mailybayeva, Z., Yermentayeva, A. R., Aikinbayeva, G. K., Akhmadiyeva, Z. K., Bekova, Z. K. (2022) “” Mind, Brain, and Education (https://onlinelibrary.wiley.com/doi/10.1111/mbe.12343).The above article, published online on 30 November 2022 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor, Paul Matusz, and Wiley Periodicals LLC. Following publication, concerns were raised by a third party. Further investigation by the Editor and the publisher revealed concerns about the validity of the data. The peer review process was found to be compromised and the authors were not able to provide underlying data to support the conclusions. As a result, the findings reported in the article are not considered reliable. The authors did not respond when informed about the decision to retract.
Redirecting tropane alkaloid metabolism reveals pyrrolidine alkaloid diversity in Atropa belladonna
Authors: Parks Hannah M. , Cinelli Maris A. , Bedewitz Matthew A. , Grabar Josh M. , Hurney Steven M. , Walker Kevin D. , Jones A. Daniel , Barry Cornelius S. 
Published: December 2022

Summary
Plant‐specialized metabolism is complex, with frequent examples of highly branched biosynthetic pathways, and shared chemical intermediates. As such, many plant‐specialized metabolic networks are poorly characterized.
The N‐methyl Δ1‐pyrrolinium cation is a simple pyrrolidine alkaloid and precursor of pharmacologically important tropane alkaloids. Silencing of pyrrolidine ketide synthase (AbPyKS) in the roots of Atropa belladonna (Deadly Nightshade) reduces tropane alkaloid abundance and causes high N‐methyl Δ1‐pyrrolinium cation accumulation. The consequences of this metabolic shift on alkaloid metabolism are unknown. In this study, we utilized discovery metabolomics coupled with AbPyKS silencing to reveal major changes in the root alkaloid metabolome of A. belladonna.
We discovered and annotated almost 40 pyrrolidine alkaloids that increase when AbPyKS activity is reduced. Suppression of phenyllactate biosynthesis, combined with metabolic engineering in planta, and chemical synthesis indicates several of these pyrrolidines share a core structure formed through the nonenzymatic Mannich‐like decarboxylative condensation of the N‐methyl Δ1‐pyrrolinium cation with 2‐O‐malonylphenyllactate. Decoration of this core scaffold through hydroxylation and glycosylation leads to mono‐ and dipyrrolidine alkaloid diversity.
This study reveals the previously unknown complexity of the A. belladonna root metabolome and creates a foundation for future investigation into the biosynthesis, function, and potential utility of these novel alkaloids.
Erythema nodosum after COVID‐19 vaccine: Report of two pediatric cases
Authors: Gonzalez‐Canete Marta , Pinto‐Pulido Elena Lucia , Vega‐Diez David , Rodriguez‐Villa Ana , Moreno‐Artero Ester , Andina Martinez David , Torrelo Antonio 
Published: December 2022

AbstractWith the introduction of large‐scale COVID‐19 vaccination programs, a variety of cutaneous manifestations have been described. We present two girls (ages 12 and 5 years) who developed erythema nodosum (EN) 3 and 14 days after Pfizer‐BioNTech COVID‐19 vaccination, respectively. While EN after COVID‐19 vaccination has been reported in adults, it is can also occur in children.
A longitudinal study of “we‐talk” as a predictor of marital satisfaction
Authors: Ouellet‐Courtois Catherine , Gravel Catherine , Gouin Jean‐Philippe 
Published: December 2022

AbstractWe‐talk, the use of first‐person plural pronouns over the use of singular pronouns when describing relationship events, is regarded as a linguistic indicator of marital relationship functioning. A meta‐analysis revealed that we‐talk is positively associated with relationship satisfaction. However, this literature is based mostly on cross‐sectional studies. This study tested the hypothesis that we‐talk would be associated with greater marital satisfaction over time. The sample comprised 77 couples enrolled in a longitudinal study of parents of preschool‐aged children. We‐talk was assessed at baseline during a marital discussion task about parenting challenges. Couples completed a measure of marital satisfaction at baseline, 6‐ and 12‐month follow‐ups. An actor–partner interdependence model examined the effects of spouses' we‐talk on their own marital satisfaction (actor effects), and their partners' marital satisfaction (partner effects). Results indicated a positive partner effect of we‐talk at baseline, but not over time. Moreover, there was an actor effect of we‐talk on changes in marital satisfaction over time, whereby low actor we‐talk was associated with a reduction in marital satisfaction, but high actor we‐talk was not associated with such a decrease. These findings suggest that greater cognitive interdependence, as indicated by we‐talk, may protect from declines in marital satisfaction over time.
A Computational Complexity Perspective on Segmentation as a Cognitive Subcomputation
Authors: Adolfi Federico , Wareham Todd , van Rooij Iris 
Published: December 2022

AbstractComputational feasibility is a widespread concern that guides the framing and modeling of natural and artificial intelligence. The specification of cognitive system capacities is often shaped by unexamined intuitive assumptions about the search space and complexity of a subcomputation. However, a mistaken intuition might make such initial conceptualizations misleading for what empirical questions appear relevant later on. We undertake here computational‐level modeling and complexity analyses of segmentation — a widely hypothesized subcomputation that plays a requisite role in explanations of capacities across domains, such as speech recognition, music cognition, active sensing, event memory, action parsing, and statistical learning — as a case study to show how crucial it is to formally assess these assumptions. We mathematically prove two sets of results regarding computational hardness and search space size that may run counter to intuition, and position their implications with respect to existing views on the subcapacity.
Adverse events caused by cord blood infusion in Japan during a 5‐year period
Authors: Hashimoto Shiho , Kato Koji , Kai Shunro , Sekimoto Tatsuya , Minemoto Mutsuko , Ishii Hiroyuki , Mori Tetsuo , Azuma Fumihiro , Ishimaru Fumihiko , Kimura Takafumi , Miyata Shigeki , Satake Masahiro , Takanashi Minoko 
Published: December 2022

AbstractBackground and ObjectivesIn Japan, cord blood is used for more than half of all unrelated stem cell transplantations. The public cord blood banks (CBBs) have been collecting information on cord blood transplantation‐related adverse events from physicians on a voluntary basis, without common definitions of the adverse reactions. The aims of this study were to compare two classification systems to improve the reporting system and to clarify the actual risk from cord blood infusion, which can then provide the impetus to take appropriate measures to reduce adverse events.Materials and MethodsWe classified the reports according to existing criteria; one is the Proposed Standard Definitions for Surveillance of Non‐Infectious Adverse Transfusion Reactions by the International Society of Blood Transfusion (ISBT) Working Party on Haemovigilance, and the other is the Common Terminology Criteria for Adverse Events (CTCAE). There were 140 cases with adverse events reported from April 2014 through March 2019.ResultsTwelve cases, such as donor‐derived leukaemia/myelodysplastic syndromes (MDS) and chromosomal aberrations reported after engraftment, were excluded from this analysis. Of the 128 cases with adverse events at cord blood infusion, the CTCAE and ISBT criteria could not classify 6 cases and 68 cases, respectively. Classifying by the CTCAE, the most common side effect was hypertension in 35 cases, followed by anaphylaxis, allergic reactions, nausea, urticaria, etc. Serious adverse events (grades 4 and 5) were mainly anaphylaxis, with a frequency of 0.23%.ConclusionIt is necessary not only to provide information on adverse events but also to standardize the reporting of adverse events to support measures to reduce them.