bluuebunny/crossref_metadata_2025_split huggingface dataset:
Willingness to use long-acting injectable PrEP among HIV- negative/unknown men who have sex with men in China: a national multicenter online survey
Authors: Fu Jiaqi , Wang Hao , Si Mingyu , Dai Zhenwei , Chen Xu , Wu Yijin , Xiao Weijun , Huang Yiman , Yu Fei , Mi Guodong , Su Xiaoyou 
Published: December 2022

AbstractBackground:Men who have sex with men (MSM) are at high risk of HIV acquisition. Long-acting injectable- (LAI-) PrEP, requiring less frequent dosing, is being studied as an alternative method to daily oral HIV PrEP. With the addition of this potential new prevention method, it expands the scope for a wider user choice and is expected to increase the acceptability and uptake of HIV prevention measures.Methods:Participants were recruited from December 2020 to March 2021through banner advertisements on web- and mobile app-based platforms on Blued, a large gay Chinese social media platform. A total of 969 HIV-negative/unknown participants were included in our study. Multivariate logistic regression was used to analyze the factors associated with the willingness to use LAI-PrEP.Results:In total, 969 participants met the inclusion criteria and finished the survey. 19.5% of participants had never tested for HIV, 66.8% of MSM had multiple male partners, and 51.6% of MSM engaged in the condomless sex with their partner. 66.3% of MSM were aware of PrEP, and only 3.9% of MSM had used PrEP before. The willingness to use daily oral PrEP and LAI-PrEP was 76.6% and 74.0%, respectively. MSM with higher education level were less likely to show willingness to use LAI-PrEP (AOR=0.561, 95%CI: 0.375-0.838). Participants who had the history of HIV test (AOR=1.684, 95%CI: 1.109-2.556), had the willingness to use daily oral PrEP (AOR=10.635,95%CI:7.434-15.214), had multiple male sexual partners (AOR=1.332, 95%CI:0.933-1.903), who used rush popper(AOR=1.494, 95%CI:1.047-2.131), and who were aware of PEP (AOR=1.659, 95%CI: 1.019-2.702) were more likely to show willingness to use LAI-PrEP.Conclusions:In our study, the study subjects had moderate awareness and low uptake of PrEP. The willingness to use daily oral PrEP and LAI-PrEP among the participants were both high. Education level, history of HIV test, multiple male sexual partnerships, rush popper use, PrEP awareness and willingness to use daily oral PrEP were factors associated with the willingness to use LAI-PrEP. This study provided some evidence for the further scale-up of PrEP among the MSM population.
Hemodynamics of thrombus formation in intracranial aneurysms: an in-silico observational study
Authors: Liu Qiongyao , Sarrami-Foroushani Ali , Wang Yongxing , MacRaild Michael , Kelly Christopher , Lin Fengming , Xia Yan , Song Shuang , Ravikumar Nishant , Patankar Tufail , Taylor Zeike A. , Lassila Toni , Frangi Alejandro F. 
Published: December 2022

Abstract
How prevalent is spontaneous thrombosis (ST) in intracranial aneurysms (IAs) for an all-size pop- ulation? How can we calibrate computational models of thrombosis based on published data from size-specific aneurysms cohorts? How does ST differ in normo- and hypertensive subjects? We ad- dress the first question by a thorough analysis of published that provide ST rates across different patient demographics and aneurysm characteristics. This analysis provides data for a subgroup of the gen- eral population, viz. large and giant aneurysms (>10 mm). Based on these observed ST rates, our novel computational modelling platform enables the first in-silico observational study of ST prevalence across a broader set of IA phenotypes. We generate 109 virtual patients and use a novel approach to calibrate two trigger thresholds: residence time (RT) and shear rate (SR), thus addressing the second question. We then address the third question by utilising this calibrated thrombosis model to provide new insights on the effects of hypertension on ST.
We demonstrate how a mechanistic ST model calibrated on a reduced IA cohort can help esti- mate ST prevalence in a broader IA population. This study was enabled through a comprehensive and fully automatic multi-scale modeling pipeline. We use an emerging property, viz. ST, as an indirect population-level validation of a complex computational modeling framework. Furthermore, our frame- work allows exploration of the influence of hypertension in ST. This lays the foundation for in-silico clinical trials of cerebrovascular devices in high-risk populations, e.g. assessing the performance of flow diverters in cerebral aneurysms for hypertensive patients.
Musculoskeletal Manifestations, Post-COVID Syndrome, Relationship with Laboratory Parameters in Hospitalized Patients Infected with COVID-19
Authors: Kuculmez Ozlem , Genctoy Gültekin , Arıkan Serap 
Published: December 2022

Abstract
Background:
This study aims to characterize the prevalence of musculoskeletal manifestations in hospitalized COVID-19 patients and the relationship between C-Reactive protein (CRP) and interleukin levels.
Methods:
A medical records review study was performed on patients at Baskent University between March 7 and December 31, 2020. The study included hospitalized patients above 18 years diagnosed with COVID-19 by polymerase chain reaction. Pregnant individuals, those with end-stage disease or missing documentation were excluded. Patient demographics and laboratory results were obtained from electronic health records and previous study performed in the same hospital. The relationship between musculoskeletal manifestations, CRP, and interleukin levels were determined. A Pvalue of less than .05 was consideredstatistically significant.
Results:
Totally, 109 patients were analyzed; 34.86% (n = 38) of the patients had arthralgia, 1.83% (n = 2) had arthritis, 41.28% (n = 45) underwentfatigue, and 32.11% (n = 35) experiencedpost-COVID syndrome. There was no correlation between musculoskeletal manifestations, CRP, and interleukin levels (P > .05). There was positive correlation between post-COVID syndrome, fatigue, duration of O2 support, duration of hospitalization (P < .05), and the patients were elderly. CRP levels were positively correlated with duration of hospitalization, duration of O2 support, history of intensive care, and duration of intensive care (P < .05). Interleukin 6 levels were positively correlated with CRP levels, duration of hospitalization, and O2 support duration (P < .05), but there was no correlation with interleukin 10 levels (P > .05).
Conclusion:
There was no correlation between musculoskeletal manifestations, CRP, and interleukin levels. Patients who are hospitalized, elderly, abnormally fatigued, or O2 supported should be followed for post-COVID syndrome.
SARS-CoV-2: gone with the evolution
Authors: Romeu Antonio R. 
Published: December 2022

Abstract
Starting at the end, evolution is erasing the imprinted CGG-CGG genetic footrprint on theSARS-CoV-2 acquired with the furin cleavage site. CGG-CGG is the original code ofthe arginine pair inthe polybasic furin cleavage site of the viralS protein. CGG-CGGis the heart of the 12nucleotide length sequence that properly inserted into the S gene encoded the PRRA motif in the early viruses. In Omicron it isHRRA. In terms of functionality, this arginine dimer in the SARS-CoV-2 S proteinis untouchable, but its code is very unfavourable for the virus. So it is plausiblethat asolution for the virus should go through an argininebias codon usage in the furin site. The aimof this study was to going onwith the longitudinal study on the evolution of this furin site arginine dimer, so essential for the virus. However, the surprise has been to discover that at least in the CQ.2 lineage, based on theavailable GISAID genomes, the original CGG-CGG arginine code has been lost and optimized in the 99.65 % of cases. It is worth noting thatthe new codon usage matches the arginine pair of the SARS-CoV-2 furin clevage site and arginine pairsof other viral proteins (e.g., nsp13, nucleocapsid) of both SARS-CoV-2and bat coronaviruses.
Practices of water, sanitation, and hygiene and its association with diarrheal infection among under-5 children in Chattogram, Bangladesh
Authors: Sujon Minhajul Abedin , Hossain Syed Billal , Chowdhury ABM Alauddin , BakiBillah Abul Hasan , Akter Nasima 
Published: December 2022

Abstract
This study aims to address the association between the practices of water, sanitation & hygiene, and diarrheal infection among Under-5 Children in Chattogram, Bangladesh. This cross-sectional survey study was conducted among 182 mothers of children under five years of age living in Chattogram City, Bangladesh. The probability proportional sampling (PPS) technique was applied to interview the study participants. The study found that 37.4% of participants had toilets with ideal sanitary facilities. Mothers' estimates of toilet cleanliness demonstrated a Pearson association with their child's diarrheal count in the previous 12 months (P = 0.007), whereas variations in toilet usage (P = 0.024), toilet cleaning frequency each week (P = 0.014) and availability of sewage channel with toilet (P = 0.012) evidence significant association with diarrheal infection frequency in the last 12 months. Washing hands after using the toilet (P = 0.002), washing fruits/vegetables before eating or cooking (P < 0.000), washing hands before and after food consumption (P < 0.012) & types of soap uses to wash hands (P = 0.017) were found significantly associated with diarrheal infection. 41.8% participants were found, who use no filtration method to purify their drinking water, however, the study found no significant association between water consumption practices with diarrheal infection frequency among respondents’ children under five years of age.
Dawki pochodzące z obrazowania w radioterapii sterowanej obrazem
Authors: Graczyk Kinga , Kruszyna-Mochalska Marta 
Published: December 2022

Współczesnym złotym standardem leczenia nowotworów z wykorzystaniem radioterapii, jest wykorzystanie do pozycjonowania pacjenta na stole terapeutycznym, obrazowania wiązką promieniowania jonizującego o kilowoltowym lub megawoltowym efektywnym potencjale przyspieszającym - wobec tego pacjent narażony jest na dodatkową dawkę. Zgodnie z zasadą ALARA, ważne jest, aby osiągnąć pożądany efekt kliniczny przy zastosowaniu możliwie najmniejszej dawki promieniowania i odnosi się to również do obrazowania.
Celem poniższego artykułu była analiza problemu jakim jest szacowanie poziomu dawek pochodzących z obrazowania różnymi technikami w radioterapii sterowanej obrazem (ang. Image-Guided Radiation Therapy - IGRT).
Porównanie technik planowania radioterapii w nowotworze piersi
Authors: Paluszyńska Marta , Bąk Olga , Borowska Patrycja , Styś Sara 
Published: December 2022

Radioterapia jest integralną częścią kompleksowego leczenia raka piersi, który stanowi ponad 20% wszystkich zachorowań na nowotwory wśród kobiet w Polsce. Wraz z postępem technologicznym, rozwijane są metody zarówno poprawiające skuteczność leczenia i komfort pacjentek jak i ograniczające toksyczność terapii. Najpopularniejszą techniką napromieniania w przypadku nowotworu piersi jest trójwymiarowa radioterapia konformalna (3DCRT, ang. Three-Dimensional Conformal Radiotherapy), gdyż zapewnia najniższe dawki promieniowania zaabsorbowane przez narządy kontrlateralne. Techniki dynamiczne, w porównaniu ze statycznymi, zapewniają w przypadku nowotworów piersi bardziej jednorodny rozkład dawki w objętości tarczowej (PTV, ang. Planning Target Volume), ale wyższe dawki w narządach krytycznych (OAR, ang. Organ at Risk). Coraz większą popularnością cieszy się metoda hybrydowa łącząca zalety planów statycznych i dynamicznych.
Celem pracy było porównanie czterech technik napromieniania piersi: 3DCRT, obrotowej z modulacją intensywności dawki (VMAT, ang. volumetric modulated arc therapy), B-VMAT (ang. Butterfly VMAT) tzw. motyl, w którym emisja wiązki terapeutycznej w pewnym zakresie kątowym łuku jest zablokowana oraz techniki hybrydowej łączącej w jednym planie leczenia pola realizowane techniką 3D i VMAT.
Dla grupy 11 pacjentek przygotowano w systemie planowania leczenia (TPS, ang. Treatment Planning System) Eclipse (Varian Medical Systems, Palo Alto, USA) i porównano plany leczenia dla każdej z omawianych technik. Oceniono rozkłady dawek, histogramy dawka-objętość (DVH, ang. Dose Volume Histogram) oraz dawki średnie w narządach krytycznych: płucach, płucu kontrlateralnym, sercu oraz zdrowej piersi.
Na podstawie analizy DVH, stwierdzono, że wszystkie analizowane plany leczenia były klinicznie akceptowalne. Za najkorzystniejsze pod względem dawek deponowanych w OAR można uznać plany leczenia techniką 3DCRT. Jednocześnie należy zauważyć, że w technice hybrydowej dawki te są jedynie nieznacznie wyższe. Dla planów VMAT zaobserwowano zwiększenie procentowych objętości narządów krytycznych objętych izodozami niskich dawek, zwłaszcza dla narządów kontrlateralnych. Zablokowanie emisji wiązki w części łuku, tj. zastosowanie techniki B-VMAT częściowo zniwelowało ten efekt, jednakże w ograniczonym zakresie. Dla tzw. „motyli”, podobnie jak w przypadku standardowych planów VMAT, objętości OAR, w których deponowane są niskie dawki promieniowania są zauważalnie wyższe niż dla planów 3DCRT i hybrydowych.
Hybrydowa technika napromieniania piersi stanowi dobrą alternatywę dla planów 3DCRT i może zostać wdrożona do zastosowania klinicznego, skracając czas realizacji planów leczenia na aparacie terapeutycznym i poprawiając tym samym komfort leczonych pacjentek.
Therapeutic Role of Desmodium Species on its Isolated Flavonoids
Authors: Singh Vedpal , Singh Rohit , Singh Manish Pal , Katrolia Archita 
Published: December 2022

Abstract:
Secondary metabolites are an important part to play a major role in society
and it was isolated from plant flavonoids and useful in the treatment of various kinds of
diseases in the human race. They are widely used as food and nutrition supplements
as well as antioxidants. Traditionally, the Desmodium species are an important tool for
the secondary metabolites to treat various diseases. Desmodium triquetrum (Fabaceae)
one of the Indian medicinal plants is widely used in the treatment of asthma and
inflammation. Three flavonoids isolated from Desmodium triquetrum Linn namely Baicalein,
Naringin and Neohesperidin are useful as antioxidants, food and nutrition
supplements, that help the body to function efficiently while protecting it against toxins
as well stressors. The role of flavonoids may be due to the presence of the phenolic
compound. Similarly, the flavonoids such as gangetin, gangetinin, desmocarpin and
desmodin isolated from the species Desmodium gangeticum are responsible for antileishmanial,
antioxidant, anti-arthritic, and immunomodulatory activities. Additionally,
isolated flavanoids from the species Desmodium triflorum show antibacterial, antiepileptic,
antifungal, and radioprotective activities. So, the aim of the present study, based
on the literature miming from the desmodium species is to acknowledge the importance
of flavonoids in human health as dietary food supplements and therapeutic uses.
The Genetic Diversity of Proteasome Genes in the T1DM Polish Population
Authors: Strózik Tadeusz , Jędrychowska-Dańska Krystyna , Zamerska Alicja , Stoczyńska-Fidelus Ewelina , Wasiak Tomasz 
Published: December 2022

Background:
Autoimmune metabolic diseases generate numerous healthy and social problems. The possible association of SNPs in the ubiquitin-proteasome system (UPS) with human pathology is under intensive study.

Objective:
In the present study, the genetic variations in PSMB5 (rs11543947), PSMA6 (rs2277460, rs1048990), PSMC6 (rs2295826, rs2295827) and PSMA3 (rs2348071) UPS gene cluster was investigated in type 1 diabetes and healthy donors in the Polish population.

Methods:
The study comprised 105 patients with type 1 diabetes mellitus (T1DM) and 214 controls. All were genotyped by PCR and restriction digestion analysis or Sanger sequencing.

Results:
Rs1048990 and rs2348071 were found to be neutral to T1DM (p-value: 0.499 and 0.656, respectively). According to the multiple loci genotype (MLG) analysis, the major homozygote of the tested polymorphisms had a protective effect. The most common MLG in the T1DM group was characterised by simultaneous risk factors at rs11543947, rs2277460, rs2295826 and rs2295827 (p-value: <0.0001 vs. MGL1). Multiple locus haplotype analysis revealed a similar dependence, with common alleles at all tested loci demonstrating a protective effect, and the rare alleles increasing T1DM risk (p-value: <0.0001 vs. MLH1).

Conclusion:
Our study suggests that the proteasome gene polymorphisms rs11543947, rs2277460, rs2295826, and rs2295827 could be potential markers for T1DM susceptibility in the Polish population.
Consequences of Concurrent Myomectomy and Caesarean Section versus
Caesarean Section Alone in the Last Two Decades: Systematic Review and
Meta-Analysis
Authors: Youshanloie Maryam Mohammadi , Vaezi Maryam , Pashazadeh Fariba 
Published: December 2022

Background:
Performing myomectomy concurrently with a caesarean section has been
controversial for many decades.

Objective:
The present study mainly aims to evaluate the consequences of concurrent myomectomy
and caesarean section versus caesarean section alone.

Methods:
In this systematic review, we have followed the Preferred Reporting Items for Systematic
Reviews and Meta-analyses (PRISMA) guidelines. Electronic resources, such as MEDLINE,
Cochrane, EMBASE, Scopus, and PubMed, were searched. A total of 3057 articles were reviewed. Of
these, 33 met the inclusion criteria and were included in the final analysis. The reviewed outcomes
were hemoglobin (Hb) before and after the operation, blood transfusion rate, hemorrhage, operation
time, duration of hospitalization, and complications, such as fever.

Results:
A meta-analysis of 33 articles with 5586 participants in the caesarean myomectomy (CM)
group and 2935 participants in the caesarean section (CS) group showed a statistically significant Hb
decrease in the CM group [MD = 0.26, CI=95%(-0.33 to -0.19)]. The transfusion rate was higher in
the CM group [OR=0.39(0.42-0.67)], and intraoperative hemorrhage was higher in the CM group
[OR=0.56 (0.45 - 0.75) CI=95%]. The mean operation time [MD=1.17(1.10 -1.24) CI=95] and hospitalization
time [MD=0.41 (0.34-0.48) CI=95%] were significantly higher in the CM group. There was
no significant difference in the incidence of fever between the two groups [MD =1.06, CI=95%,
p=0.923(0.78-1.43)].

Conclusion:
Concurrent CM is associated with a reduction in mean Hb and an increase in operation
time and hospitalization time; however, it prevents additional surgery and costs; it is worthwhile to
perform myomectomy at the time of caesarean section, especially by experienced surgeons with necessary
preparations.
Malignant Progression of a Superior Cerebellar Tentorium Solitary
Fibrous Tumor in the Pineal Region with Intracranial Metastases: A Case
Report and a Literature Review
Authors: Demir Mustafa Kemal , Yapıcıer Ozlem , Ozdamarlar Umut , Ertem Onder , Kılıc Turker 
Published: December 2022

Background:
Pineal region solitary fibrous tumors (SFT) incorporate a histologic spectrum
of rarely metastasizing mesenchymal neoplasms that include tumors formerly classified as hemangiopericytoma.

Case Report:
Here, we describe a rare case of SFT of the pineal region in a 25-year-old man with a
literature review. After the first surgery, the tumor reappeared as a local low-grade recurrence, followed
by metastasis to the right parietal lobe, and then hyperacute intraparenchymal hematoma at the
metastatic site, and later presentation of widespread intracranial intra-axial and extra-axial metastases
during the follow-up period. Systemic metastases were not detected. The histopathological evaluation
of the resected tissues confirmed the malignant progression of the tumor.

Conclusion:
The diagnosis of SFT of the pineal region through clinical and imaging features can be
considerably challenging. Large size, intratumoral cystic areas, and intense contrast enhancement are
the main conventional imaging characteristics of the tumor. Surgery is the first preferential treatment.
All recurrent or metastatic cases were grade II or grade III tumors. Adjuvant radiotherapy should be
added to surgical treatment in high-grade tumors. Gamma knife radiosurgery is a treatment option for
intracranial metastases.
Deforestación en el municipio de Bacalar, Quintana Roo, México durante el período 1993-2017
Authors: Huchin Ochoa Saida Aglae , Navarro-Martínez Angélica , Ellis Edward Alan , Hernández Gómez Irving Uriel 
Published: December 2022

La deforestación por cambios en el uso del suelo forestal a otro no forestal ha sido considerada una de las principales causas de pérdida de diversidad biológica, incremento de emisiones de bióxido de carbono y otros gases de efecto invernadero. En las últimas décadas se han manifestado importantes cambios en la cobertura forestal del municipio de Bacalar. Con la finalidad de contribuir a la gestión sostenible de las selvas de dicho municipio, a través del análisis de imágenes de satélite y sistemas de información geográfica, se estudió la dinámica de cambio en la cobertura forestal durante el periodo 1993-2017; además se determinaron los principales impulsores de la deforestación con la integración de información ecológica, socioeconómica e institucional georreferenciadas a escala de comunidad y aplicando la prueba estadística ANOVA. Los resultados muestran que durante el periodo de estudio se perdió un total de 75 263 hectáreas de cobertura forestal, lo que representa una tasa anual de deforestación de 0.7%. La mayor deforestación ocurrió en la región suroeste de Bacalar. La deforestación en comunidades ejidales fue asociada con la urbanización, parcelación de tierras comunales, número de terrenos bajo producción, así como la antigüedad y población total. Ejidos con mayor porcentaje de vegetación secundaria y madura, y menor número de ejidatarios y avecindados, tienden a deforestar menos. Esta información es de gran utilidad para orientar las políticas públicas relacionadas con la planeación del territorio en la región.
Recolección de productos forestales no maderables en el Parque Nacional Cofre de Perote y zonas adyacentes: estudio de caso en El Escobillo, Veracruz, México
Authors: Isidro-Vázquez María Antonieta , Lascurain-Rangel Maite , Ramírez Fernando , González-Hernández Citlalli Alhelí , Gómez-Díaz Jorge Antonio , López-Acosta Juan Carlos 
Published: December 2022

Se presenta un estudio sobre recolección de productos forestales no maderables (PFNM) en la población de El Escobillo, Veracruz, México, y zonas adyacentes del Parque Nacional Cofre de Perote (PNCP). Se registraron 70 especies (45 plantas vasculares, dos briofitas y 23 hongos), clasificadas en siete categorías de uso, destacando el comestible (31) con el mayor ingreso por venta, seguido por el medicinal (21), el de leña y el ceremonial por volumen recolectado para autoconsumo y el artesanal para la venta. De acuerdo con la normatividad mexicana (NOM-059-SEMARNAT-2010), en el área de estudio el hongo pananaca, los hongos cochinitos y la palma chimale se encuentran en la categoría de amenazada y el hongo de perfume está sujeto a protección especial. Se identificaron 33 sitios de recolección ubicados en tres zonas del PNCP y cinco sistemas de manejo. El sistema “montaña” representa la mayoría de los sitios de recolección y especies silvestres, principalmente hongos para venta y autoconsumo. La recolección de PFNM representa un ingreso (sin considerar los egresos) estimado en MXN 943 624 anuales. Es necesario promover la participación de los habitantes del PNCP, como custodios y manejadores de los PFNM en estrategias sustentables, con especial énfasis en la integración de sus conocimientos y formas de organización, así como considerar la colaboración con las organizaciones de la sociedad civil, gobierno, empresas y academia.