bluuebunny/crossref_metadata_2025_split huggingface dataset:
ZBM‐H‐induced activation of GRP78 ATPase promotes apoptosis via annexin A7 in A549 lung cancer cells
Authors: Ning Junya , Wang Xiaotan , Li Nan , Cui Xiaoling , Li Na , Zhao Baoxiang , Miao Junying , Lin Zhaomin 
Published: February 2022

AbstractHypochlorous acid (HOCl) is an essential signal for the regulation of cancer cell fate, including autophagy and apoptosis. HOCl regulated autophagy by affecting the oxidation modification of glucose‐regulated protein 78 (GRP78) and the activity of GRP78 ATPase. The mechanism of GRP78 ATPase in cell apoptosis has however not yet been clarified. Here we reported that ZBM‐H, as a probe of HOCl, was able to directly bind to GRP78 in the presence or absence of ATP. Following ZBM‐H treatment, the interaction between GRP78 and annexin A7 (ANXA7) was promoted, and this was accompanied by increased phosphorylation of integrin β4 (ITGB4). In addition, ZBM‐H enhanced the phosphorylation of ANXA7. ABO, an inhibitor of ANXA7, inhibited ZBM‐H‐induced ITGB4 phosphorylation and apoptosis, while ANXA7 activator SEC had opposite effect. Collectively, these data provide new evidence for the mechanism by which ZBM‐H‐induced activation of GRP78 ATPase regulates apoptosis of A549 lung cancer cells.
Fearlessness about death and suicide planning predict lethality of adolescent suicide attempts during and following treatment
Authors: Krantz Savannah M. , Heerschap Jessica , Balzen Kennedy M. , Sachs Raney , Kennard Betsy D. , Emslie Graham J. , Stewart Sunita M. 
Published: February 2022

AbstractIntroductionThe rate of adolescent suicide attempt has increased drastically over the past 10 years. However, little is known regarding what predicts a more versus less lethal attempt, which is of critical interest to clinicians managing this at‐risk population. We sought to extend the study of lethality in adolescents by exploring its relationship with two recognized risk‐factors for suicide attempt: fearlessness about death (FAD) and suicide planning.MethodsParticipants (N = 254) were administered measures of FAD and depressive symptoms upon entering intensive outpatient treatment for adolescents exhibiting suicidal thoughts and behaviors. Attempts made between treatment entry and 6 months following discharge (n = 47) were scored on a 4‐point ordinal scale of lethality. The resulting continuum ranged from no attempt to attempts of low to moderate levels of lethality.ResultsFAD and suicide planning distinguished between levels of lethality of future attempt at the bivariate and multivariate level. FAD's predictive relationship with lethality while controlling for age, sex, depression, and prior attempt diminished when suicide planning was covaried.ConclusionFAD and suicide planning significantly predicted more versus less lethal future attempts in our sample of adolescents in a clinical setting. Our findings suggest that FAD influences the lethality of a future attempt by promoting planning for suicide. More studies are needed to assess whether the brief FAD scale might be a valuable adjunct in the clinical management of youth with suicidal thoughts and behaviors.
Safe to speak: Fostering psychological safety among incoming predoctoral dental students
Authors: Wolcott Michael D. , Kornegay Elizabeth C. , Brame Jennifer L. 
Published: February 2022

AbstractPurposeTo describe the implementation and impact of an introductory session on psychological safety for incoming first‐year Doctor of Dental Surgery (DDS) learners.MethodsIn August 2020, first‐year DDS students participated in a 2‐h online instructional session focused on defining psychological safety, the behaviors that promote and disrupt it, and setting expectations for learner and faculty behavior to foster it. Learners worked in small groups to discuss the various components of psychological safety and document their discussion in a collaborative workspace before a large group debriefs. Participants were requested to complete an electronic survey before and after the session to evaluate their change in knowledge, confidence in performing tasks to foster psychological safety, and perceptions about their level of control. Six months after the session, learners were requested to participate in a focus group for additional feedback and reflections.ResultsSeventy‐four participants completed the before and after experience survey. There was a statistically significant increase in knowledge of the components of psychological safety and perceptions of control. In addition, self‐reported measures of confidence to perform the tasks increased from an average rating of 36% confident before the session to 86% confident afterward. In the experience, learners were active in their discussion and generated many ideas about behaviors that promote and disrupt psychological safety, which informed the creation of learner and faculty classroom expectations.ConclusionEngaging learners in discussions about psychological safety can be a useful activity to establish expectations and create group norms that may support collaborative learning environments.
Tree embeddings and tree‐star Ramsey numbers
Authors: Yan Zilong , Peng Yuejian 
Published: February 2022

AbstractWe say that a graph can be embedded into a graph if contains an isomorphic copy of as a subgraph. Guo and Volkmann conjectured that if is a connected graph with at least vertices and minimum degree at least , then any tree with vertices and maximum degree at most can be embedded into . In this paper, we give a result slightly stronger than this conjecture and obtain a sufficient and necessary condition that a tree with vertices and maximum degree at most can be embedded into a connected graph G with at least vertices and minimum degree at least . Our result implies that the conjecture of Guo and Volkmann is true with one exception. We also give an application to the Ramsey number of a tree versus a star.
Japanese Lead EXtraction (J‐LEX) registry: Annual report 2019
Authors: Shoda Morio , Kusano Kengo , Goya Masahiko , Nishii Nobuhiro , Imai Katsuhiko , Okamoto Yoji , Takegami Misa , Nakao Yoko M. , Miyamoto Yoshihiro , Nogami Akihiko , Shimizu Wataru ,   J‐LEX registry investigators
Published: February 2022

AbstractAlong with the incremental cases of cardiac implantable electronic devices implantation or upgrade, the lead‐related complications are also in rise year after year. The most common and serious lead‐related complication is infection that needs a transvenous lead extraction (TLE) as the first‐line therapy. TLE is also performed for abandoned leads in case of lead failure or device upgrade, and for lead‐related trouble such as pain, vessel stenosis or occlusion, too many leads, tricuspid valve regurgitation, and difficulty of radiation therapy. This registration has been performed by the Japanese Heart Rhythm Society and started in July 2018. The first reported data of the Japanese Lead Extraction (J‐LEX) from July 2018 to December 2019 were underestimated since the number of patients and hospitals increased gradually because of the approval process of each hospital’s IRB. The TLE procedure was attempted to 1253 leads among 661 patients. Complete removal was achieved in 96.7% of the target leads and the clinical success was obtained in 98.9% of the patients. Perioperative complications were observed in 4.1% of the patients. The annual J‐LEX report reflects a real‐world TLE medicine in Japan and demonstrates that the clinical outcome is similar to former reports from high‐volume centers in North America and European countries.
A self‐verification perspective on customer mistreatment and customer‐directed organizational citizenship behaviors
Authors: Amarnani Rajiv K. , Restubog Simon Lloyd D. , Shao Ruodan , Cheng David C. , Bordia Prashant 
Published: February 2022

SummaryCustomer mistreatment events play a major role in employees' subsequent customer service behaviors, and is believed to have implications for employees' sense of self. We extend this line of research by developing a self‐verification account of the relationship between customer mistreatment and customer‐directed OCBs (OCB‐Cs) by examining theoretically prescribed novel mechanisms (i.e., self‐verification) and boundary conditions (i.e., self‐esteem and entity customer appreciation) for this relationship. We conducted a programmatic series of studies using daily diary (Study 1), audio vignette (Study 2), and behavioral experiment (Study 3) designs to test the proposed model. The overall pattern of results showed that customer mistreatment led employees to feel less self‐verified, especially among those with higher trait self‐esteem. These employees in turn were more likely to withhold OCB‐Cs, especially among those perceiving lower levels of entity customer appreciation. Overall, these results deepen our understanding of the role of the self‐concept in how employees experience and react to customer mistreatment‐‐depending on how employees see themselves and how they see their customers in general.
A novel bone registration method using impression molding and structured‐light 3D scanning technology
Authors: He Guangyu , Ricca Jacob M. , Dai Amos Z. , Mustahsan Vamiq M. , Cai Yanming , Bielski Michael R. , Kao Imin , Khan Fazel A. 
Published: February 2022

AbstractAccurate bone registration is critical for computer navigation and robotic surgery. Existing registration systems are expensive, cumbersome, limited in accuracy and/or require intraoperative radiation. We recently reported a novel method of registration utilizing an inexpensive, compact, and X‐ray‐free structured‐light 3D scanner. However, this technique is not always practical in a real surgical setting where soft tissue and blood can obstruct the continuous line‐of‐sight required for structured‐light technology. We sought to remedy these limitations using a novel technique using rapid‐setting impression molding to capture bone surface features and scan the undersurface of the mold with a structured‐light scanner. The photonegative of this mold is compared to the preoperative computed tomography (CT)‐scan to register the bone. A registration accuracy study was conducted on 36 CT‐scanned femur sawbones, simulating typical exposure in hip/knee arthroplasty and bone tumor surgery. A cadaver experiment was also conducted to evaluate the feasibility of using the impression molding in a more realistic operating room setting. The registration accuracy of the proposed technique was 0.50 ± 0.19 mm. This was close to the reported accuracy of 0.43 ± 0.18 mm using a structured‐light scanner without impression molding (p = 0.085). In comparison, historical values for “paired‐point” and intraoperative CT image‐based registration methods currently used in modern robotic/computer‐navigation systems were 0.68 ± 0.14 mm (p = 0.004) and 0.86 ± 0.38 mm, respectively. The registration accuracy of the cadaver experiment was consistent with that of sawbone experiments. Although future studies are needed to extend to human subjects, this study shows that the impression molding method can produce comparable or better registration accuracy than the existing techniques.
Postharvest quality of ‘Cripps Pink’ apple fruit influenced by ethylene antagonists during controlled atmosphere storage with photocatalytic oxidation
Authors: Tokala Vijay Yadav , Singh Zora , Kyaw Poe Nandar 
Published: February 2022

AbstractBACKGROUNDThe present study investigated the efficacy of 1H‐cyclopropa[b]naphthalene (NC) and 1H‐cyclopropabenzene (BC) with respect to antagonizing ethylene action and maintaining postharvest fruit quality in ‘Cripps Pink’ apple stored in a controlled atmosphere comprising 3.45 ± 0.45% oxygen and 2.40 ± 0.36% carbon dioxide with photocatalytic oxidation (PCO) at 0 ± 1 °C and 90 ± 5% relative humidity.RESULTSThe BC, NC, and 1‐methylcyclopropene (1‐MCP) fumigation treatments delayed the climacteric peaks onset and retarded ethylene production rates compared to control fruit. Treatments with ethylene antagonist also maintained fruit firmness (up to 1.12 times), titratable acidity (up to 1.08 times), malic acid (up to 1.23 times), ascorbic acid (up to 1.12 times) and total phenol levels (up to 1.19 times) higher compared to that in control fruit. The 1‐MCP was more efficient in reducing the rates of ethylene production compared to NC and BC, but, in the case of all other fruit quality parameters investigated, the effect of NC and BC treatments were on a par with 1‐MCP.CONCLUSIONThe NC and BC have the potential to be used as ethylene antagonists in ‘Cripps Pink’ apple fruit stored in a controlled atmosphere with PCO. The efficacy of different concentrations of NC and BC in downregulating ethylene action, as well as interactive effects of PCO on the performance of ethylene antagonists, still warrants further investigation. © 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Phenolic Hydroxyl‐Functionalized Covalent–Organic Frameworks for Formal [3+2] Reaction
Authors: Ma Baiwei , Xu Yimeng , Hu Fujia , Zhang Guangci , Zheng Xiaofei , Wang Zhuo , Qiao Huijie , Yang Dehong , Mi Liwei 
Published: February 2022

AbstractCovalent–organic frameworks (COFs) are rarely used as heterogeneous catalysts for cycloaddition reactions, especially in [3+2] reactions. In this study, 4,4′,4″,4‴‐(pyrene‐1,3,6,8‐tetrayl) tetra‐aniline, 2,5‐dihydroxyterephthalaldehyde, and 2,5‐dimethylterephthalaldehyde are used to construct COFs with high porosity, crystallinity, and chemical stability. The phenolic and methyl groups on the pore channel of the COFs are precisely tuned to effectively serve as heterogeneous catalysts for the formal [3+2] reaction between 5‐alkoxyoxazoles and azodicarboxylate or nitrosobenzene compounds. The resultant COFs that are assembled from adjustable building unit ratios exhibit excellent catalytic performance for the targeted [3+2] reaction.
Multi‐bands antenna for metal‐rimmed handset terminals
Authors: Qiu Peiyi , Feng Quanyuan , Miyahara Koto , Kanaya Haruichi 
Published: February 2022

AbstractThis article proposes a compact hepta‐band antenna for unbroken metal‐rimmed mobile applications. The proposed antenna includes a vertical copper plate, an open slot and printed multi‐branches on both sides of the substrate. The 1‐λ bezel mode is employed to cover the GSM850/900 operating bands. By combining the different modes of the multiple branches, the proposed antenna is capable of covering GSM1800/1900, UMTS, GSM2300/2500 bands. Besides, a design strategy for enhancing the bandwidth of lower and higher bands is introduced. The mentioned structures are combined on the 122 × 60 mm2 substrate board without lumped elements. The measured results show our proposed antenna achieves three‐wide bandwidths, which typically agree with the simulation results. Meanwhile, the performances of radiation patterns, efficiencies, and gains are also obtained.
Pilot study on the impact of a carbohydrate loading drink on postprandial glycemic responses and gastric emptying in adults with prediabetes and type 2 diabetes mellitus
Authors: Cassady Bridget A. , McDonald Joshua D. , Yalawar Menaka , Baggs Geraldine E. , Maki Kevin C. 
Published: February 2022

AbstractBackgroundPreoperative carbohydrate (CHO) loading improves patient outcomes but is not extensively studied in individuals with diabetes mellitus (DM), resulting in limited professional recommendations. This study examined postprandial glycemic responses and gastric emptying rates following consumption of a CHO drink in adults with and without DM.MethodsA single‐arm, nonrandomized pilot trial was conducted in adults without DM (non‐DM) (47.5 ± 2.5 years), with pre‐DM (55.8 ± 3.0 years), and with type 2 DM (56.2 ± 2.5 years). Following an overnight fast, participants consumed a 50 g CHO drink followed by 1.5 g liquid paracetamol. Venous blood samples were collected at baseline (ie, t = 0 min) and 15, 30, 45, 60, 90, 120, 150, 180, 210, and 240 min for plasma glucose and serum insulin and paracetamol concentrations to assess gastric emptying.ResultsParticipants with DM were older and had a higher body mass index than non‐DM participants (31.2 ± 0.9 vs 28.2 ± 0.9). Fasting glucose and hemoglobin A1c levels differed significantly across groups (non‐DM: 95.4 ± 3.6 mg/dl and 5.2% ± 0.1%; pre‐DM: 111.6 ± 3.6 mg/dl and 5.8% ± 0.1%; DM: 167.4 ± 3.6 mg/dl and 7.2% ± 0.1%). Compared with the non‐DM group, DM had increased glucose responses at 30–180 min. Glucose returned to baseline at 150 min in the non‐DM and pre‐DM groups compared with 210 min in the DM group. Paracetamol concentrations were not significantly different between the non‐DM and DM groups.ConclusionBlood glucose returned to baseline within ~2.5 h in non‐DM and pre‐DM groups and ~3.5 h in participants with DM following ingestion of a CHO drink. No consistent differences in gastric emptying rates were observed between participants with and without DM.
Alfaxalone improved in acute stress‐induced tactile hypersensitivity and anxiety‐like behavior in mice
Authors: Yoshizawa Kazumi , Ukai Saki , Kuroda Junpei , Yamauchi Tsugumi , Yamada Daisuke , Saitoh Akiyoshi , Iriyama Satoshi , Nishino Shoichi , Miyazaki Satoru 
Published: February 2022

AbstractStress has been shown to affect brain activity and exert potent and complex modulatory effects on pain. Several behavioral tests have shown that acute stress produces hyperalgesia, depending on the stress conditions. In the present study, we investigated the effects of single restraint stress on the tactile threshold and anxiety sensitivity in mice. Mice were evaluated for the tactile threshold using von Frey filaments and for anxiety sensitivity using the elevated plus maze (EPM) test. Tactile thresholds were lowered by both 2 and 4 hour of restraint stress, but anxiety‐like behaviors were observed only after 4 hour of restraint stress in the EPM test. In addition, we found that alfaxalone, which is a positive allosteric modulator of the γ‐aminobutyric acid (GABA)A receptor, prevented restraint stress‐induced hyperalgesia‐like and anxiety‐like behaviors. These results indicate that GABAergic function appears to be critical in the regulation of physical stress‐induced hyperalgesia and anxiety.
The effects of the COVID‐19 pandemic on weight loss in participants in a behavioral weight‐loss intervention
Authors: Zaman Adnin , Sloggett Kelsey J. , Caldwell Ann E. , Catenacci Victoria A. , Cornier Marc‐Andre , Grau Laura , Vetter Céline , Rynders Corey A. , Thomas Elizabeth A. 
Published: February 2022

AbstractObjectiveThis study aimed to assess the effects of the COVID‐19 pandemic on weight loss, physical activity, and sleep in adults with overweight or obesity participating in a 39‐week weight‐loss intervention.MethodsParticipants (n = 81, 85% female, mean [SD] age 38.0 [7.8] years, BMI 34.1 [5.7] kg/m2) were enrolled in 3 separate cohorts. Cohorts 1 and 2 were studied prior to the pandemic (pre‐COVID cohorts). Cohort 3 (COVID cohort) transitioned to a virtual intervention at week 6, when “stay‐at‐home” orders were implemented in Colorado. Weight was assessed at baseline, week 12, and week 39 with clinic scales before the pandemic and home scales during the pandemic. Diet was assessed with Likert scales at weeks 4, 8, and 12. Physical activity and sleep were assessed at baseline and week 12 with actigraphy.ResultsParticipants in the COVID cohort reported greater dietary adherence (p = 0.004) and lost more weight than those in the pre‐COVID cohorts at week 12 (−7.7 [3.3] kg vs. −3.7 [3.0] kg, p < 0.001) and week 39 (−8.5 [4.4] kg vs. −2.8 [4.6] kg, p < 0.001). Energy intake did not differ between cohorts (p = 0.51). The COVID cohort increased both sedentary time while awake and time in bed at night.ConclusionsAlthough the pandemic caused disruptions for the COVID cohort, participants still achieved weight loss with continued behavioral support.
Rational design of in‐situ‐modified resorcinol formaldehyde aerogels for removing chlortetracycline antibiotics from aqueous solutions
Authors: Behzadi Alireza , Hashemi Motlagh Ghodratollah , Raef Mohammad , Motahari Siamak 
Published: February 2022

AbstractOrganic resorcinol formaldehyde aerogels with distinct pore sizes/surface areas in different ratios of (resorcinol/catalyst) R/C = 300, 400, 600 and (resorcinol/water) R/W = 2 were prepared utilizing sol–gel technique and in‐situ modified by incorporating 1 wt% meta‐phenylenediamine. The porous nanostructure, surface area, and pore size of the aerogels were characterized by scanning electron microscopy, Brunauer–Emmett–Teller, and Barrett–Joyner–Halenda techniques. Raman spectroscopy, Fourier transform infrared spectroscopy, and X‐ray diffraction were employed to get understanding into the chemical structure. Furthermore, we investigated the removal percentage of antibiotic via UV–vis spectroscopy. The ability of modified aerogels in removing chlortetracycline (CTC) at different pH values (2–12), contact times (2–24 h), initial concentrations of CTC (50–100 mg L−1), and the adsorbent dose (2–10 mg) was evaluated. Consequently, the adsorption optimum conditions were found, the adsorption isotherms were measured, and isotherm models were fitted to the results to interpret the kinetics of adsorption. The obtained fitting parameters using the pseudo‐second‐order model revealed a well alignment with the experimental data. Finally, we demonstrated that the modified‐aerogels have a high capacity in CTC antibiotics removal up to 90% and an adsorption capacity of 440 mg g−1 as well as an efficient regeneration capacity for five consecutive cycles without significant degradation of the adsorption properties.
A machine learning approach for the design of hyperbranched polymeric dispersing agents based on aliphatic polyesters for radiation‐curable inks
Authors: Vanpoucke Danny EP , Delgove Marie AF , Stouten Jules , Noordijk Jurrie , De Vos Nils , Matthysen Kamiel , Deroover Geert GP , Mehrkanoon Siamak , Bernaerts Katrien V 
Published: February 2022

AbstractPolymeric dispersing agents were prepared from aliphatic polyesters consisting ofδ‐undecalactone (UDL) andβ,δ‐trimethyl‐ε‐caprolactones (TMCL) as biobased monomers, which were polymerized in bulk via organocatalysts. Graft copolymers were obtained by coupling of the polyesters to poly(ethylene imine) (PEI) in the bulk without using solvents. Various parameters that influence the performance of the dispersing agents in pigment‐based UV‐curable matrices were investigated: chemistry of the polyester (UDL or TMCL), polyester/PEI weight ratio, molecular weight of the polyesters and of PEI. The performance of the dispersing agents was modelled using machine learning in order to increase the efficiency of the dispersant design. The resulting models were presented as analytical models for the individual polyesters and the synthesis conditions for optimally performing dispersing agents were indicated as a preference for high‐molecular‐weight polyesters and a polyester‐dependent maximum polyester/PEI weight ratio. © 2022 The Authors.Polymer Internationalpublished by John Wiley & Sons Ltd on behalf of Society of Industrial Chemistry.