bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Postpartum Depression, Associated Factors, Social Support, and Professional Assistance: A Cross-Sectional Study in Port Said, Egypt
Authors: Elkashif Mirfat Mohamed Labib 
Published: March 2022

INTRODUCTIONPostpartum depression is a mental illness that affects post-childbirth mothers. It is associated with psychological and social risk factors such as negative childhood experiences and pregnancy and childbirth problems. Postpartum depression has not been a focus of concern in Egypt. Therefore, this study aimed to identify the prevalence of postpartum depression, its associated factors, social support, and professional assistance in Port Said, Egypt.METHODOLOGYA random sampling strategy was used to select 540 women ten weeks postpartum. Data were collected using a questionnaire during an interview to identify potential risk factors for postpartum depression. The modified Arabic version of the Edinburgh Postpartum Depression Scale was used to assess symptoms of postpartum depression which is a multidimensional measure of social communication. Statistical analysis was completed using SPSS 25.0. software.RESULTSIt was found that 24.4% of women were at risk for postpartum depression. Social support from family and friends was significantly associated with mitigation of postpartum depression.CONCLUSIONThis study affirmed postpartum depression was a common health problem among 540 women who gave birth in Port Said, Egypt. Early detection and efficient screening methods to detect postpartum depression should be applied, especially in areas with a high risk for this condition. Early detection may prevent complications for mothers, babies, and families.
Challenges and Suggestions to Promote Maternal Service Provision and Utilization Under the Free Maternal Health Policy in Ghana: Perspectives of Health Directors and Facility Managers
Authors: Dalinjong Philip Ayizem , Wang Alex Y. , Homer Caroline S. E. 
Published: March 2022

INTRODUCTIONTo promote service uptake and reduce maternal deaths, a policy was implemented under Ghana’s National Health Insurance Scheme in 2008. This study explored the benefits and limitations of the policy, health system challenges, and community-level challenges resulting in suggestions to mitigate the challenges.METHODSThe study design was cross-sectional, utilizing qualitative data collection. It was carried out in the Kassena-Nankana East Municipality, Ghana, involving in-depth interviews (IDIs) with directors of Ghana Health Service and facility managers. A total of eight IDIs were conducted. Data were transcribed, read, and analyzed based on themes which were presented using key quotes.RESULTSThe policy promoted the use of services. Nonetheless, challenges existed as a result of limited service coverage, inadequate human resources and infrastructure, lack of medications and equipment, lack of transport, and the influence of religion, culture, and family members. There was a need to strategize so that women with a low socioeconomic status would receive service over those of a high socioeconomic status. Other suggestions included the inclusion of family planning services, accreditation of private facilities, provision of a shift system for specialists to move to rural areas, and provision of incentives for health personnel in rural areas. It was also suggested that health personnel make known their challenges as well as to provide education on women’s rights and service expectations. The provision of transport vouchers to women as well as alternative arrangements to be made with private transport owners were also suggested.CONCLUSIONImplementing the suggestions may improve service provision and utilization leading to the reduction of maternal deaths and contributing towards achieving universal health coverage.
Episiotomy at Public Health Institutions in Hosaena Town, Southern Ethiopia: An Institution-Based Cross-Sectional Study
Authors: Wassie Semahegn Tilahun , Gultie Ketema Teklemariam , Gendisha Ukke Gebresilasea , Hiwot Aynalem Yetwale , Mamo Desalegn Girma 
Published: March 2022

BACKGROUNDEpisiotomy was first suggested about two centuries back to prevent perineal tear as well as a fetal head injury. However, there have been controversies about its benefits over its side effects. The magnitude of episiotomy varies across the world. No study was conducted in the study area. This study was aimed at assessing the magnitude and factors associated with episiotomy at public health institutions.SUBJECTS AND METHODSInstitutional-based cross-sectional study design was employed in four public health institutions in Hosaena Town. Data were collected through interviews administered structured questionnaires and supplemented with maternal chart review and anthropometric measurement from May 1st to June 30th, 2019. Study participants were selected using a systematic random sampling technique. EpiData 3.02 and SPSS version 21 software were used for data entry, and analysis, respectively. Descriptive statistics, bivariate and multivariable logistic regression analysis were done. Variables at p-value < 0.2 were transferred to multivariable logistic regression analysis. Then variables at p-value <0.05with 95% CI were considered as statistically significant and AOR was used to interpret factors associated with episiotomy. Tables and graphs have been used to present the results.RESULTSA total of 410 delivered mothers were included in the study and the magnitude of episiotomy was 57.6%with a mean of 95% CI = 0.53–0.63.Being primiparous (AOR = 16.96, 95% CI: 9.26, 31.05), meconium-stained amniotic fluid (AOR = 3.82, 95% CI: 1.84, 7.96), Second stage of labor lasting more than 2 hours (AOR = 2.43, 95% CI: 1.11, 5.32), births attended by non-midwife professionals (AOR = 2.26, 95% CI: 1.24, 4.14) and newborns head circumference >35 cm (AOR = 5.73, 95% CI: 3.29, 10.00) were factors significantly associated with episiotomy.CONCLUSIONSEpisiotomy was performed in more than half of the mothers included in the study. All the responsible bodies from the administrative to clinical practitioners should be in action to lower the magnitude of episiotomy by assuring that it is practiced restrictively with scientific indications.
Hubungan Pasang Surut Air Laut terhadap Pergerakan Transportasi Kapal di Pelabuhan Trisakti Banjarmasin Provinsi Kalimantan Selatan
Authors: Efendi Muhammad , Hasadi Hasa Noor , Rukmana Ananta Dandy 
Published: March 2022

Abstrak: Penelitian ini berjudul “Hubungan Pasang Surut air laut terhadap Pergerakan transportasi Kapal di Pelabuhan Trisakti Banjarmasin”. Tujuan dalam penelitian ini adalah untuk mengetahui pola pasang surut, pergerakan kapal dan hubungannya. Hubungan pasang surut dengan pergerakan kapal di Pelabuhan Trisakti Banjarmasin menunjukkan pergerakan Transportasi kapal di pelabuhan tersebut, bermanfaat untuk perencanaan segala sesuatu yang berkaitan dengan kemajuan dan kesejahteraan penduduk, misalnya dengan lancarnnya transportasi kapal maka sirkulasi barang yang masuk ke Propinsi Kalimantan Selatan akan mengalami kelancaran juga. Hasil penelitian berdasarkan perhitungan dengan menggunakan rumus Korelasi menunjukkan bahwa hubungan pasang surut air laut dengan pergerakan transportasi Kapal di Pelabuhan Trisakti Banjarmasin mempunyai hubungan yang relatif sangat lemah antara tinggi pasang dengan pergerakan kapal yang merapat ke dermaga dalam periode 5 tahun dari tahun 2007 sampai 2011 dengan persentase tiap tahunnya sebagai berikut; (1) 51% ditahun 2007. (2) 0.4% ditahun 2008. (3) 1% ditahun 2009. (4) 1.1% ditahun 2010. (5) 1% ditahun 2011. Hal ini menunjukkan bahwa pasang surut tidak terlalu besar mempengaruhi pergerakan transportasi kapal di Pelabuhan Trisakti Banjarmasin. Kata Kunci: Hubungan, Pasang surut, Kapal, Pelabuhan
A Comparative Study of Two Robotic Thyroidectomy Procedures: Transoral Vestibular Versus Bilateral Axillary-Breast Approach
Authors: he qingqing , Zhu Jian , Li Xiaolei , Wang Meng , Wang Gang , Zhou Peng , Wang Dan , Liu Changrui , Zheng Luming , Zhuang Dayong , Fan Ziyi , Yu Fang , Ma Yunhan , Cao Xianjiao , Wang Shuai , Yue Tao , Hu Jinzhi 
Published: March 2022

Abstract
Objective: To compare the surgical outcomes between the transoral-vestibular robotic thyroidectomy (TOVRT) and bilateral axillo-breast approach robotic thyroidectomies (BABART).Methods: A total of 99 patients with papillary thyroid carcinoma without distant metastasis were enrolled in this study from May 2020 to April 2021. 99 patients had received an ultrasound guided fine needle aspiration prior to surgical intervention so the appropriate procedure can be planned. 49 patients underwent TOVRT, and another 50 patients underwent BABART. We performed TOVRT using three intraoral ports or adding the right axillary fold incision to enhance fine countertraction of tissue for radical oncological dissection. The clinical data such as age, gender, height, weight, BMI, primary tumor size, number of central lymph node removed, central lymph node metastasis, operating time, total hospital stays, postoperative hospital stays, total postoperative drainage volume, postoperative pain score, cosmetic effect and complications were observed and analyzed. Results: There were no significant differences in gender, height, weight, BMI and removed central lymph nodes between the two groups (all P > 0.05). Lobectomy or total thyroidectomy with central lymph node dissection using two different robotic thyroidectomy approaches were performed in 99 cases. In all cases, we used intraoperative neuro-monitoring system and confirmed that all RLNs were preserved. All patients had papillary thyroid carcinomas (PTC)． Patients accepted TOVRT were younger than who accepted BABART and patients who accepted TOVRT had smaller primary tumor size. The TOVRT group had a longer surgical time than the BABART group, and was superior in postoperative drainage volume and cosmetic effect (visual analogue scale, VAS)(all P < 0.05). There was no significant difference in lymph node metastasis, hospital stay and postoperative pain score (numerical rating scale, NRS) between the two groups (P > 0.05). However, there were some peculiar complications such as paresthesia of the lower lip and the chin (one case), surgical site infection (one case) and skin burn (one case) in transoral thyroidectomy. Conclusion: Transoral-vestibular robotic thyroidectomy is safe and feasible for selected patients, which is a potential alternative approach for patients who require no scarring of the neck.
Analysis of the miRNA expression profile of laboratory red crucian carp under low-dose caesium-137 irradiation
Authors: Wang Yude , Liao Xiaoli , Chen kejie , Zhang Zhaohui , Liu Yuxin , Yang JingPing , Wu Duansheng 
Published: March 2022

Abstract
Radiation can cause the differential expression of biological miRNA molecules, but research on miRNAs and biological radiation damage is insufficient. This research was based on the development of the experimental animal resource laboratory red crucian carp (LRCC) to explore the feasibility of its application in the detection of low-dose ionizing radiation-induced biological damage in aquatic environments and the development of related molecular markers. Adult LRCC were irradiated with caesium-137 at 0.3 Gy, while RNA-seq and bioinformatics techniques were used to identify miRNAs that were differentially expressed relative to their levels in the nonirradiation group. Analysis of liver sections showed that liver cells in the radiation group showed nuclear pyknosis. In this study, 34 miRNAs differentially expressed in the liver of LRCC after irradiation were identified, among which seven were new crucian carp miRNAs; the prediction analysis of their target genes showed that a total of 632 target genes were predicted. The results of comprehensive GO enrichment and KEGG pathway analyses showed that these target genes were mainly involved in energy transfer and material catabolism, especially malonyl-CoA biosynthesis, acetyl-CoA carboxylase activity, fatty acid biosynthesis and metabolism, and pyruvate metabolism; in addition, the AMPK signalling pathway was the most active pathway. This study shows that LRCC have a certain sensitivity to radiation, and the miRNAs identified may be used as preselected biomarkers for radiation damage detection.
QKI Degradation in Macrophage by RNF6 Protects Mice from MRSA Infection Via Enhancing PI3K P110β Dependent Autophagy.
Authors: Zhai Dongsheng , Wang Wenwen , Ye Zichen , Xue Ke , Chen Guo , Hu Sijun , Yan Zhao , Guo Yanhai , Wang Fang , Li Xubo , Xiang An , Li Xia , Lu Zifan , Wang Li 
Published: March 2022

Abstract
Background: Sepsis is a fatal condition commonly caused by Methicillin-resistant Staphylococcus aureus (MRSA) with a high death rate. Macrophages can protect the host from various microbial pathogens by recognizing and eliminating them. Earlier we found that Quaking (QKI), an RNA binding protein (RBP), was involved in differentiation and polarization of macrophages. However, the role of QKI in sepsis caused by pathogenic microbes, specifically MRSA, is unclear. This study aimed to investigate the role of QKI in regulation of host-pathogen interaction in MRSA-induced sepsis and explored the underlying mechanisms.Methods: Transmission electron microscope and immunoﬂuorescence were used to observe the autophagy level in macrophages. Real-time PCR and western blot were used to analyzed the expression of mRNA and protein respectively. The potential protein interaction was analyzed by iTRAQ mass spectrometry and Immunoprecipitation. RNA fluorescence in situ hybridization, dual-luciferase reporter assay and RNA immunoprecipitation were used to explore the mechanism of QKI regulating mRNA of PI3K-p110β.Results: The mRNA level of QKI was aberrantly decreased in monocytes and PBMCs of septic patients with the increasing level of plasma procalcitonin (PCT). Then the mice with myeloid specific knockout of QKI was challenged with MRSA or Cecal Ligation and Puncture (CLP). Mice in these two models displayed higher survival rates and lower bacterial loads. Mechanistically, QKI deletion promoted phagocytosis and autophagic degradation of MRSA via activating p110β (a member of Class IA phosphoinositide 3-kinases) mediated autophagic response. QKI expression in macrophages led to the sequestration of p110β in mRNA processing (P) bodies and translational repression. Upon infection, the direct interaction of RNF6, a RING-type E3 ligase, mediated QKI ubiquitination degradation and facilitated PI3K-p110β related autophagic removal of pathogen. The administration of nanoparticles with QKI specific siRNA significantly protected mice from MRSA infection. Conclusions: This study disclosed the novel function of QKI in the P body mRNA regulation during infection. QKI degradation in macrophage by RNF6 protects mice from MRSA infection via enhancing PI3K-p110β dependent autophagy. It suggested that QKI may serve as a potential theranostic marker in MRSA-induced sepsis.
Optimal Multiple Echo Recombined Gradient Echo Imaging Conditions for the Triangular Fibrocartilage Complex
Authors: Hori Hiroki , Naka Takanori , Minami Hiroaki , Hondera Tetsuichi , Takahashi Toshiyuki , Takahashi Mitsuyuki 
Published: March 2022

Abstract
This study investigated the optimal scan conditions of multiple echo recombined gradient echo to obtain high signal and contrast-to-noise ratio in the triangular fibrocartilage complex. The triangular fibrocartilage complexes of 10 healthy volunteers were imaged with varying repetition times and flip angles. The signal value and contrast-to-noise ratio were measured at the disk proper, lunar bone, and synovial fluid. Data expressed as means ± standard deviation were compared by Student’s t-tests. The significance level was set at P < 0.05. The tendency for contrast-to-noise ratio change was similar to that of the average signal value and peaked at 600 ms repetition time and 50˚ flip angle. Therefore, a repetition time of 600 ms and a flip angle of 50° were the optimal multiple echo recombined gradient echo scan conditions to obtain high signal and a contrast-to-noise ratio for the triangular fibrocartilage complex.
The extent and nature of television food and non-alcoholic beverage advertising to children during Chinese New Year in Beijing, China
Authors: Lei Nan , Liu Zechen , Xiang Lin , Ye Lihong , Zhang Juan 
Published: March 2022

Abstract
Background: Exposure to food and non-alcoholic beverage advertisements (F&B ads) on television, which can affect children’s nutrition knowledge, food consumption, diet quality, and purchasing preferences, is one aspect of the obesogenic environment. This aspect has been well-studied and assessed in many countries. In China, however, only few studies have been done in earlier years and all of them were focus on regular days. This study aimed to assess the extent and nature of F&B ads on TV during the public holiday directed towards children aged 4-14 years in Beijing.Method: Top 3 channels viewed by children aged 4–14 years in Beijing were selected by TV viewership data, survey, and expert consultation. Each channel was recorded for 7 days (24 hours) during the public holiday of the Chinese New Year. F&B ads were coded and analyzed following the adapted food promotion module of INFORMAS protocol. Three nutrient profile models were used to classify F&B ads as healthy or unhealthy F&B.Results: Of the 10,082 ads in 504-hour recorded programs, 42.9% were F&B ads. The hourly average ads and F&B ads per channel were 19.8 (SD=15.32) and 8.6 (SD=9.84), while that was higher on the national children’s channel (17.15 (SD=12.25), P＜0.05) than other channels. Of F&B ads classified with the three nutrient profile models, more than 55% were unhealthy for children. The categories most frequently advertised were savory snacks, milk drinks, nonpermitted milk drinks, cakes/sweet biscuits, and beverages. Unhealthy F&B ads were more likely to use promotional characters, brand benefit claims, and health claims than permitted F&B ads (P＜0.05).Conclusion: Children in Beijing were exposed to a high proportion of unhealthy F&B ads during the Chinese New Year holiday. Our findings support the need to assess and regulate TV F&B ads marketing for children.
Expression of the Interferon Regulatory Factor Family and Its Prognostic Value in Acute Myeloid Leukemia
Authors: Zeng Jiawei , Yu Lian , Zhong Mengya , Zhang Li , Zheng Huijian , Li Guowei , Zhou Yong , Xu Bing 
Published: March 2022

Abstract

The interferon regulatory factor (IRF) family was correlated to diverse diseases. However, systematic studies of the IRF gene family in acute myeloid leukemia (AML) have not been reported yet. We analyzed the different transcripts of the IRF family associated with the survival and clinical data of patients with AML via the GEPIA, LinkedOmics, and TCGA databases. The results revealed that the expression levels of IRF1/2/4/5/7/8/9 were up-regulated while those of IRF3/6 were down-regulated in AML patients compared with normal donors. Moreover, high expression levels of IRF1/7/9 were significantly correlated with poor overall survival (OS). We further collected the clinical and survival data of newly diagnosed AML patients from the First Affiliated Hospital of Xiamen University from April 2018 to September 2020. In consistent with the outcomes from bioinformatics, the results from analysis of the biospecimens in our center showed that high expression levels of IRF1 and IRF7 predicted a poor prognosis. Overall, our study highlighted that the overexpression of IRF1/7/9 may be related with adverse prognosis and dismal survival in AML patients, indicating that the IRF family might serve as potential therapeutic targets.
Comprehensive Analysis of the PD-L1 and Immune Infiltrates of N6-Methyladenosine Related Long Non-Coding RNAs in Bladder Cancer
Authors: Xue MQ , Wang YL , Wang JC , Wang XD , Wang XJ , Zhang YQ 
Published: March 2022

Abstract
Background & Aim:Bladder cancer (BLCA) is one of the most frequent genitourinary cancers, with a high rate of morbidity and mortality. The connection of m6A-related lncRNAs with PD-L1 and tumor immune microenvironment (TIME) in BLCA prognosis was extensively investigated in this study, which could suggest novel therapeutic targets for further investigation. Results:30 m6A-associated lncRNAs with predictive values from the TCGA data set were identified with co-expression analysis. Cluster2 was correlated with a poor prognosis,upregulated PD-L1 expression, and higher immune ratings. Cluster2 had larger amounts of resting CD4 memory-activated T cells, M2 macrophages, neutrophils, and NK cells infiltration. “CHEMOKINE SIGNALING PATHWAY” was the most significantly enriched signaling pathway according to GSEA，which may play an important role in the diffrent immune cell infiltrates between cluster1/2. The risk model for m6A-related lncRNAs could be employed in a prognostic model to predict BLCA prognosis, regardless of other clinical features. Collectively, m6A-related lncRNAs were linked to PD-L1 and TIME, which would dynamically affect the number of tumor-infiltrating immune cells. Conclusion:m6A-related lncRNAs may be key mediators of PD-L1 expression and immune cells infiltration and may strongly affect the TIME of BLCA.
Corrosion-resistant and high-entropic non-noble metal bifunctional electrodes for PEM-type water electrolyser
Authors: Tajuddin Aimi , Wakisaka Mitsuru , Ohto Tatsuhiko , Yu Yue , Fukushima Haruki , Tanimoto Hisanori , Elumalai Ganesan , Misu Yoshitatsu , Jeong Samuel , Fujita Jun-ichi , Tada Hirokazu , Fujita Takeshi , Takano Kaori , Matsuoka Koji , Sato Yasushi , Ito Yoshikazu 
Published: March 2022

Abstract
To realise sustainable hydrogen economy, corrosion-resistant non-noble metal catalysts are needed to replace catalysts based on noble metals. The combination of passivation elements and catalytically active elements is crucial for simultaneously achieving high corrosion resistance and high catalytic activity. Here, we investigated the self-selection/reconstruction characteristics of multi-element (nonary) alloys that could automatically redistribute suitable elements and rearrange surface structures under the target reaction conditions. We found the following synergetic effect (i.e. cocktail effect) among the elements: Ti, Zr, Nb, and Mo significantly contribute to passivation, whereas Cr, Co, Ni, Mn, and Fe enhance the catalytic activity. Practical water electrolysis experiments showed that the self-selected/reconstructed multi-element alloy demonstrates high performance in proton exchange membrane (PEM)-type water electrolysis without obvious degeneration during stability tests, verifying the alloy’s resistance to corrosion in a practical PEM electrolyser.