bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perbandingan kadar Thyroid Stimulating Hormone (TSH) dan kadar Free T4 (FT4) antara metode Fluorescence Immunoassay (FIA) dan metode Electrochemiluminescence Immunoassay (ECLIA) di RSUP Sanglah, Bali, Indonesia
Authors: Nabu Ekarini Katharina Yunarti , Herawati Sianny , Mulyantari Ni Kadek , Lestari Anak Agung Wiradewi , Prabawa I Putu Yuda 
Published: February 2022

Background: Diagnostic and therapeutic cases of hyperthyroidism can be identified by examining the levels of Thyroid Stimulating Hormone (TSH) and Free T4 (FT4). There are several examination methods, namely the Fluorescence Immunoassay (FIA) and the Electro-Chemiluminescence Immunoassay (ECLIA) method. This study aims to evaluate the difference in TSH and FT4 level in the FIA method and ECLIA method.Method: This study used observational analytic methods cross sectional design, with 45 samples serum patient with hyperthyroid in January-March 2019. Examine level TSH and FT4 levels with FIA methods (NANO ENTEK FRENDTM) and ECLIA method (Cobas e601 ROCHE). Data were analyzed using SPSS version 17 for Windows.Results: Most of the respondents were aged 25-34 years (28.8%) and female (86.7%). There was no significant difference in the mean TSH level on examination using the ECLIA method (0.60±0.79 mIU/L) and the FIA method (0.63±0.76 mIU/L) (p=0.639). In addition, there was no significant difference in FT4 both in the examination using the ECLIA method (1.67±1.05 ng/dl) and the FIA method (1.69±1.72 ng/dl) (p=0.745).Conclusions: There was no significant difference between TSH and FT4 in both ECLIA and FIA methods. Latar Belakang: Diagnosis maupun pemantauan terapi kasus hipertiroid dapat diketahui dengan pemeriksaan kadar hormon Thyroid Stimulating Hormone (TSH) dan Free T4 (FT4). Terdapat beberapa metode pemeriksaan yaitu metode Fluorescence Immunoassay (FIA) dan metode Electro-Chemiluminescence Immunoassay (ECLIA). Penelitian ini bertujuan untuk mengevaluasi perbedaan kadar TSH dan FT4 metode FIA dan metode ECLIA.Metode: Penelitian ini menggunakan metode observasional analitik dengan desain potong lintang pada 45 sampel serum penderita hipertiroid selama periode Januari-Maret 2019. Dilakukan pemeriksaan kadar TSH dan FT4 dengan metode FIA (NANO ENTEK FRENDTM) dan metode ECLIA (Cobas e601 Roche). Data dianalisis dengan SPSS versi 17 untuk Windows.Hasil: Sebagian besar responden berusia 25-34 tahun (28,8%) dan berjenis kelamin perempuan (86,7%). Tidak terdapat perbedaan bermakna rerata kadar TSH pada pemeriksaan menggunakan metode ECLIA (0,60±0,79 mIU/L) maupun metode FIA (0,63±0,76 mIU/L) (p=0,639). Disamping itu, tidak juga terdapat perbedaan bermakna rerata kadar FT4 baik pada pemeriksaan menggunakan metode ECLIA (1,67±1,05 ng/dl) maupun metode FIA (1,69±1,72 ng/dl) (p=0,745).Kesimpulan: Tidak ada perbedaan yang bermakna antara kadar TSH dan FT4 pada metode ECLIA dan FIA.
Inflammation after corneoscleral rupture and traumatic cataract due to blunt trauma in a child: a case report
Authors: Suhardi Clara Verlina , Bungaran Graecia , Ihsan Nashrul 
Published: February 2022

Background: Ocular trauma is the most common cause of acquired monocular blindness in children. It is because of the inflammation following corneoscleral rupture and traumatic cataracts due to blunt trauma. This case study aims to evaluate the corneoscleral rupture and traumatic cataracts due to blunt trauma in a child.Case Presentation: We present a 5-year-old male who sustained blunt trauma to his right eye. He presented with blurry vision, mild pain and watering from the affected eye. His examination revealed visual acuity of 6/60 in the right eye (RE), corneal laceration extending from 3 o’clock towards 11 o’clock with possible extension to the sclera, and cortical lens matter in the anterior chamber. The patient underwent globe rupture repair under general anesthesia immediately. Postoperative day one revealed 2 mm hypopyon thick inflammation cells and fibrin. He was on topical steroids and topical antibiotics. The fourth postoperative day showed reduced inflammation, wound sutures in place and absence of hypopyon, thick membranous in the pupil. The patient is then referred to the Pediatric Ophthalmology department for a follow-up operation of clearing lens particle remnants to reduce inflammation and IOL insertion. Conclusion: Management of the injury and traumatic cataract is crucial to prevent vision loss and amblyopia, to maintain binocularity, prevent strabismus or even phthisis bulbi. Along with early management, routine follow-up examination for prevention of other unwanted complications is advised.
Peran sirkumsisi sebagai pencegahan infeksi herpes genetalis: suatu studi kohort retrospektif
Authors: Wardhana Made , Windari Martina , Sadeli Marrietta Sugiarti , Wiraguna Anak Agung Gde Putra , Puspawati Ni Made Dwi , Indira I Gusti Ayu Agung Elis , Mahariski Pande Agung 
Published: February 2022

Background: Recurrent genital herpes (RGH) is a sexually transmitted infection that is a serious public health problem and is quite prominent in most countries worldwide. Management for this infection is antiviral and circumcision. Male circumcision significantly reduces human immunodeficiency virus (HIV) infection and other sexually transmitted infections. This research aims to evaluate circumcision efficacy as the prevention for herpes simplex virus type 2 (HSV-2) infection compared with oral acyclovir.Methods: This research is an experimental study with a retrospective cohort approach. We included 45 males, 24 subjects circumcised and 21 subjects without circumcision and took oral acyclovir as standard treatment. RGH was diagnosed based on typical clinical manifestation. Follow up treatment every two weeks and continued to 2 months after circumcised and given with oral acyclovir. Successful treatment was stated without recurrent genital herpes.Results: Of 24 circumcised subjects, 19 were cured, and five non-circumcised subjects suffered recurrent genital herpes (not cured). Among 21 subjects without circumcision was cured, and 12 subjects were not cured. Based on these results, the value of NNT= 2.7.Conclusion: Circumcision can be considered effective in reducing the incidence of HGR and prevent recurrence of HGR with the NNT value of 2.7. Latar Belakang: Herpes genetalis rekuren (HGR) merupakan infeksi menular seksual menjadi masalah kesehatan masyarakat yang serius dan cukup menonjol pada sebagian besar negara di dunia. Penanganannya adalah oral dengan antivirus dan tindakan sirkumsisi. Sirkumsisi pada pria secara signifikan mengurangi insiden infeksi human immunodeficiency virus (HIV) dan penyakit infeksi menular lainnya. Penelitian ini mengevaluasi efikasi sirkumsisi sebagai pencegahan infeksi virus herpes simpleks tipe 2 (HSV-2) dibandingkan dengan pemberian obat asiklovir.Metode: Studi ekperimental dengan pendekatan retrospektif kohort dengan mengikutsertakan 45 subjek pria dewasa, 24 subjek disirkumsisi dan 21 tanpa sirkumsisi dan hanya diberikan asiklovir sebagai obat standar. Diagnosis HGR dilakukan secara klinis dengan yang manifestasi klinis yang khas da pemeriksaan Tzanck. Setelah pemberian terapi dilakukan kontrol setiap 2 minggu sampai 2 bulan. Terapi dinyatakan berhasil bila tidak ada kekambuhan.Hasil: Dari 24 subjek disirkumsisi, 19 subjek dinyatakan sembuh dan 5 subjek mengalami kekambuhan (tidak sembuh). Dari 21 subjek tanpa sirkumsisi, 9 subjek dinyatakan sembuh dan 12 subjek dinyatakan tidak sembuh. Berdasarkan hasil ini didapatkan nilai NNT=2,7.Simpulan: Sirkumsisi dapat dinilai cukup efektif mengurangi angka kejadian HGR dan dapat mencegah kekambuhan HGR dengan nilai NNT 2.7.
Problem diagnostik seorang penderita endokarditis infektif dengan komplikasi perdarahan intrakranial: Sebuah laporan kasus
Authors: Simarmata Franky , Nugraha Ida Bagus Aditya , Wita I Wayan , Sindhughosa Dwijo Anargha 
Published: February 2022

Introduction: Infective Endocarditis (IE) is a disease frequently affecting heart valves. The diagnosis is relatively simple, however it could be difficult in unspecific symptoms. Intracranial complications of patients with IE rarely happen.Case: The case was a 64 years-old male with sudden decrease of consciousness 12 hours prior to admission and diagnosed as a hemorrhagic stroke. He had a history of heavy smoking for about 10 years. Infective Endocarditis (IE) was diagnosed by Duke Criteria, and from this patient we found the vegetation at mitral valve with diameter 1.09 x 0.73 cm. Treatment for the patient is antibiotic according to sensitivity test of blood culture. The patient was discharged with improvement of condition. However, in approximately three months after discharge, the patient got hospitalized again due to the same condition and passed away.Conclusion: Infective endocarditis is a relatively rare disease. In our case we had a definite IE patient with a spectrum of neurological events complicating this disease. The presence of cerebral hemorrhage complications makes the patient's prognosis worse. Pendahuluan: Endokarditis Infektif (IE) merupakan penyakit yang umumnya menyerang katup jantung. Diagnosis pada umumnya relatif sederhana, namun dapat menjadi sulit gejala yang ditemukan tidak spesifik. Komplikasi intrakranial pasien dengan IE jarang terjadi.Laporan Kasus: Seorang laki-laki 64 tahun dengan penurunan kesadaran mendadak 12 jam sebelum masuk rumah sakit (MRS) dan didiagnosis sebagai stroke hemoragik. Pasien memiliki riwayat perokok berat selama kurang lebih 10 tahun. Endokarditis infektif (IE) di diagnosis dengan kriteria Duke, dan dari pasien ini ditemukan vegetasi pada katup mitral dengan diameter 1,09 x 0,73 cm. Pengobatan untuk pasien adalah antibiotik berdasarkan uji sensitivitas kultur darah. Pasien dipulangkan dengan kondisi perbaikan. Namun, sekitar tiga bulan setelah keluar, pasien kembali dirawat di rumah sakit karena kondisi yang sama dan meninggal dunia.Simpulan: Endokarditis infektif merupakan penyakit yang relatif jarang. Dalam laporan kasus ini, pasien dengan spektrum kejadian neurologis yang menyulitkan penyakit IE. Adanya komplikasi perdarahan otak membuat prognosis pasien semakin buruk.
Mikrobiota usus pada dermatitis atopik
Authors: Gotama Dewi , Wardhana Made , Santoso Adeline , Sissy Sissy 
Published: February 2022

Atopic dermatitis (AD) is a multifactorial disease caused by immune dysregulation, genetic susceptibility, environmental factors, and impaired barrier function. The health burden caused by this disease is significant and can impact psychological, social and financial costs, along with systemic comorbidities. Several studies have reported the gut microbiota in AD patients. Several studies have reported the gut microbiota in AD patients. The gut microbiota is thought to play an important role in the development of AD by regulating the immune system's maturation. Intestinal microbiota alteration affects the balance of the immune system through metabolites' production, which will cause the microenvironment to become inflamed. Currently, the close relationship between the gut microbiota and the development of the immune system, especially in maintaining the balance of Th-1 and Th-2 responses, is the rationale for providing probiotic supplements to prevent or treat allergic and atopic diseases. Dermatitis atopik (DA) merupakan penyakit multifaktorial yang diakibatkan disregulasi imun, suseptibilitas genetik, faktor lingkungan, dan gangguan fungsi barier. Beban kesehatan yang diakibatkan penyakit ini bersifat signifikan dan dapat berdampak pada kerugian psikologis, sosial, dan finansial, disertai komorbiditas sistemik. Terdapat beberapa studi yang telah melaporkan mikrobiota usus pada pasien DA. Mikrobiota usus diduga memainkan peran penting dalam perkembangan DA dengan meregulasi maturasi sistem imun. Alterasi mikrobiota usus mempengaruhi keseimbangan sistem imun melalui produksi metabolit, yang akan menyebabkan lingkungan mikro mengalami inflamasi. Saat ini hubungan erat antara mikrobiota usus dan perkembangan sistem imun, khususnya dalam menjaga keseimbangan respon Th-1 dan Th-2 menjadi dasar pemikiran pemberian suplemen probiotik untuk mencegah atau mengatasi penyakit alergi dan atopi.
Satu Kasus Langka: Harlequin Ichthyosis
Authors: Pramita I Gusti Ayu Sattwika , Karna Ni Luh Putu Ratih Vibriyanti 
Published: February 2022

Introduction: Harlequin ichthyosis is a genetic skin disease due to mutations in the ABCA12 gene inherited in an autosomal recessive manner. It is a severe form of ichthyosis characterized by a distinct clinical appearance of a thick stratum corneum. Harlequin ichthyosis is rarely found, and patients generally die a few days after birth.Case description: We reported a baby girl aged one day with thick and cracked skin since birth. Physical examination revealed eclabium, ectropion, microtia, hyperflexion of the arms and legs, and hypoplasia of the fingers and toes. Dermatological examination showed thick yellowish-white scales separated by deep and erythematous fissures. The patient was placed in an incubator and was given supportive care, including nutrition and fluid through an orogastric tube, oleum olivarum as a moisturizer, gentamicin cream 0.1%, and gentamicin eye ointment 0.3%. The patient died after 21 days of treatment.Conclusion: Harlequin ichthyosis has a poor prognosis and a high mortality rate due to impaired skin barrier functions that lead to dehydration, impaired thermoregulation, respiratory problems, and infections. Management of harlequin ichthyosis needs a multidisciplinary team and supportive care, consisting of fluid, electrolyte, and nutrition management, maintaining skin hydration, eye care, and preventing respiratory failure or sepsis. Pendahuluan: Harlequin ichthyosis adalah penyakit kulit genetik yang diturunkan secara resesif autosomal dan merupakan bentuk berat dari iktiosis akibat adanya mutasi pada gen ABCA12. Penyakit ini ditandai dengan adanya gambaran klinis yang khas berupa penebalan stratum korneum. Harlequin ichthyosis jarang ditemukan dan umumnya pasien meninggal beberapa hari setelah kelahiran.Kasus: Dilaporkan seorang bayi perempuan berumur 1 hari dengan keluhan kulit tebal dan pecah-pecah sejak lahir. Pada pemeriksaan fisik ditemukan eklabium, ektropion, mikrotia, hiperfleksi lengan dan kaki, serta hipoplasia jari-jari tangan dan kaki. Berdasarkan pemeriksaan status dermatologikus didapatkan skuama tebal berwarna putih kekuningan yang dipisahkan fisura. Pasien diberikan perawatan suportif berupa perawatan dalam inkubator, pemberian nutrisi melalui OGT, pelembab topikal oleum olivarum, antibiotik topikal gentamisin krim 0,1 %, dan salep mata gentamisin 0,3%. Pasien meninggal setelah perawatan selama 21 hari. Simpulan: Harlequin ichthyosis memiliki prognosis yang buruk dan angka kematian yang tinggi akibat gangguan dari barier kulit yang menyebabkan dehidrasi, gangguan termoregulasi, gangguan nafas dan infeksi. Penatalaksanaan pasien harlequin ichthyosis adalah multidisiplin dan bersifat suportif, terdiri atas manajemen cairan dan elektrolit, perawatan secara intensif dalam inkubator, pemberian nutrisi, menjaga hidrasi kulit, perawatan mata, dan pencegahan terjadinya gangguan napas, atau sepsis.
Diagnosis dan penatalaksanaan nodul tiroid tunggal: Sebuah laporan kasus
Authors: Pramudita Nyoman , Kusuma Anak Agung Gede Budhi 
Published: February 2022

Background: Thyroid nodules are abnormal lesions in the form of masses or nodules found in thyroid tissue. Thyroid nodules have a prevalence of about 8% in the adult population. A single thyroid nodule is asymptomatic and is generally discovered incidentally on physical examination or imaging. Diagnosis is made by physical examination, imaging examination and cytopathological examination. The management of a single thyroid nodule can be done by providing interventional therapy and surgery. The purpose of this case report is to describe the diagnosis and management of a single thyroid nodule case in Wangaya General Hospital.Case description: A 52-year-old male patient came to the Surgical Clinic at Wangaya General Hospital with complaints of a lump on the left neck in the past eight months. The lump is felt to be enlarged and painless. The patient's diagnosis was confirmed by cytologic examination, which revealed a follicular nodule with a benign tendency. The patient was given surgical therapy in the form of left thyroidectomy.Conclusion: Single thyroid nodule is quite rare. Treatment of a single thyroid nodule was adjusted according to the results of the cytologic examination. The prognosis for a single thyroid nodule with benign cytology results is generally reasonable. However, it is necessary to follow-up the patient considering the false negative value of the cytological examination. Latar belakang: Nodul tiroid adalah lesi abnormal berupa massa atau nodul yang terdapat dalam jaringan tiroid. Nodul tiroid memiliki prevalensi sekitar 8% pada populasi dewasa. Nodul tiroid tunggal bersifat asimtomatik dan umumnya ditemukan secara tidak sengaja saat pasien melakukan pemeriksaan fisik atau pencitraan. Penegakan diagnosis dilakukan dengan pemeriksaan fisik, pemeriksaan pencitraan dan pemeriksaan sitopatologi. Penatalaksanaan nodul tiroid tunggal dapat dilakukan dengan pemberian terapi intervensi dan pembedahan. Tujuan pelaporan kasus ini adalah untuk menjabarkan diagnosis dan penatalaksanaan pada salah satu kasus nodul tiroid tunggal di RSUD Wangaya.Deskripsi kasus: Seorang pasien laki-laki berusia 52 tahun datang ke Poli Bedah RSUD Wangaya dengan keluhan benjolan pada leher kiri sejak 8 bulan yang lalu. Benjolan dirasakan membesar dan tidak nyeri. Diagnosis pasien ini dikonfirmasi melalui pemeriksaan sitologi yang menunjukkan suatu nodul folikular dengan kecenderungan ke arah jinak. Pasien diberikan terapi pembedahan berupa tiroidektomi sinistra.Simpulan: Nodul tiroid tunggal cukup jarang terjadi. Terapi nodul tiroid tunggal disesuaikan dengan hasil pemeriksaan sitologi. Prognosis nodul tiroid tunggal dengan hasil sitologi jinak umumnya baik, namun perlu dilakukan follow-up terhadap pasien menimbang nilai negatif palsu dari pemeriksaan sitologi.
Laporan kasus: demam rematik akut pada anak
Authors: Melinda Fitriana , Sucipta Anak Agung Made 
Published: February 2022

Background: Acute rheumatic fever is an autoimmune sequelae caused by group A streptococcal infection. Acute rheumatic fever causes a systemic inflammatory response followed by disorders of the brain, heart, skin, and joints. This disease tends to recur and begins with Streptococcus beta-hemolytic group A infection in the respiratory tract.Case description: A boy aged 9 years 7 months with complaints of pain in both legs so that his legs are difficult to move since one day before being admitted to the hospital. The patient also had a fever for about 1 week, cough and sore throat before complaining of joint pain but the patient did not seek treatment. The patient had a history of recurrent sore throat and was rarely treated. Physical examination revealed that both knees were erythematous, warm and there was tenderness and limited leg movement due to pain. On examination of the tonsils found T2-T2 is not hyperemic. Laboratory examination showed positive ASTO. The diagnosis was made as acute rheumatic fever and treated with erythromycin and aspirin.Conclusion: Acute rheumatic fever can be established using the Jones criteria and modified WHO. In patients with typical symptoms or manifestations according to the major and minor criteria, it will be easier to establish the diagnosis. Latar belakang: Demam rematik akut adalah suatu sekuele autoimun akibat infeksi streptokokus grup A. Kondisi demam rematik akut menyebabkan suatu respon inflamasi sistemik yang diikuti oleh adanya gangguan pada organ otak, jantung, kulit, dan sendi. Penyakit ini cenderung terjadi berulang dan diawali dengan infeksi Streptococcus beta hemolyticus grup A pada saluran napas.Deskripsi kasus: Anak laki-laki berusia 9 tahun 7 bulan dengan keluhan nyeri pada kedua kaki sehingga kaki sulit untuk digerakkan sejak satu hari sebelum masuk RS. Pasien juga mengalami demam sekitar 1 minggu, batuk dan nyeri tenggorok sebelum mengalami keluhan nyeri sendi namun pasien tidak berobat. Pasien memiliki riwayat nyeri tenggorok berulang dan jarang diobati. Pemeriksaan fisik didapatkan kedua lutut eritema, teraba hangat dan terdapat nyeri tekan serta gerakan kaki terbatas karena nyeri. Pada pemeriksaan tonsil didapatkan T2-T2 tidak hiperemis. Pemeriksaan laboratorium menunjukkan ASTO positif. Diagnosis ditegakkan sebagai demam reumatik akut dan diberikan terapi eritromisin dan aspirin.Simpulan: Demam rematik akut dapat ditegakkan menggunakan kriteria Jones dan modifikasi WHO. Pada pasien dengan gejala khas atau manifestasi sesuai dengan kriteria mayor dan minor akan mempermudah penegakkan diagnosis.
Temuan radiologi dalam kelainan kongenital atresia jejunum: serial kasus
Authors: Gunawan Listyani , Anandasari Pande Putu Yuli , Patriawan Putu 
Published: February 2022

Background: Jejunoileal atresia is an emergency due to mechanical gastrointestinal obstruction, a rare case with a prevalence rate of 1-3 per 10,000 births. There is no difference in incidence by gender. Delay in treatment results in huge losses in terms of malnutrition, failure to thrive, and even death. These case series aim to evaluate radiological findings in congenital jejunal atresia.Case Presentation: There were 3 patients with the main complaint of bilious vomiting. These three patients underwent a plain abdominal x-ray examination, obtained a picture of a high total obstruction with a triple bubble picture, or had a dilated picture of the proximal obstruction. Partial obstruction based on plain radiographs in one of the patients was found, followed by an examination of contrast meal which filled smoothly up to the jejunum segment with a windsock appearance. The three cases have been proven through surgery, various types of jejunal atresia were obtained. Intestinal resection was performed, followed by an end-to-end jejunal anastomosis.Conclusion: Correct diagnosis determines the appropriate treatment for the patient. Plain abdominal radiograph as an initial examination in assessing total or partial obstruction in the jejunum, with a typical triple bubble or dilated bowel segment proximal to the obstruction. The windsock appearance of the jejunal segment on the contrast meal confirms the diagnosis of the jejunal web. Latar Belakang: Atresia jejunoileal merupakan kegawatdaruratan akibat obstruksi mekanik gastrointestinal, yang merupakan kasus jarang dengan angka prevalensi 1-3 per 10000 kelahiran, tidak ada perbedaan insiden berdasarkan gender. Terlambatnya tatalaksana mengakibatkan kerugian yang besar baik malnutrisi, gagal tumbuh, hingga kematian. Laporan kasus ini bertujuan untuk mengevaluasi temuan radiologi dalam kelainan kongenital atresia jejunum.Laporan Kasus: Terdapat 3 pasien dengan keluhan utama muntah bilosa. Kemudian dari pemeriksaan foto polos abdomen didapatkan gambaran obstruksi total letak tinggi dengan gambaran triple bubble atau memiliki gambaran dilatasi dari proksimal obstruksi. Obstruksi parsial berdasarkan foto polos pada salah satu pasien, dilanjutkan pemeriksaan contrast meal yang mengisi lancar hingga segmen jejunum dengan windsock appearance. Ketiga kasus tersebut telah terbukti melalui hasil operasi, didapatkan atresia jejunum berbagai tipe. Dilakukan reseksi usus dilanjutkan anastomosis end-to-end jejunal.Kesimpulan: Diagnosis yang tepat, menentukan tatalaksana yang sesuai bagi pasien. Foto polos abdomen sebagai pemeriksaan inisial dalam menilai obstruksi total atau parsial pada jejunum, dengan gambaran khas triple bubble atau dilatasi segmen usus proksimal dari obstruksi. Windsock appearance segmen jejunum pada contrast meal mempertajam diagnosis jejunal web.