bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pyroptosis-Related Gene Markers Can Effectively Diagnose Endometriosis and Predict Prognosis
Authors: S. J.M. , S. T. , Liu Yang , C. J.S. , Y. X.L. , L. D.Y. , B. J. , S. Y. , M. Y.S. 
Published: August 2022

Abstract
Endometriosis (EM) is a chronic inflammatory disease, affecting 10% of women and girls of reproductive ages around the globe. Pyroptosis ,a type of pro-inflammatory programmed cell death (PCD), has been associated with EM in recent studies.However,the expression of pyroptosis-related genes (PRGs) in EM and its relationship with diagnosis and prognosis are not clear.In this study,it was discovered that 32 PRGs differed in expression between EM and normal tissues, which were related to diagnosis and prognosis. Firstly, ROC analysis of a single gene was performed based on PRGs ,and then subjected to the corresponding multiomics analysis, prognostic analysis and diagnostic analysis. Secondly,the gene expression profiles of EM group dataset were consistently grouped based on PRGs by the consencesClusterPlus package. Pheatmaps were used to construct a principal component analysis (PCA) diagram of the dataset to determine the potential diagnostic value of these genes and to determine their expression patterns in different subtypes.Thirdly,The Gene ontology (GO) and Kyoto Encylopedia of Genes and Genomes (KEGG) were used for functional enrichment analysis. The results suggested that the risk was related to immune response. In conclusion, PRGs have an important roles in tumour immunity and can be used to predict the prognosis of EM.
Biomass and Soil Carbon Stocks of Selected Agroforestry practice and cultivated land, in Tehuledere District, South Wollo Zone, Ethiopia
Authors: Seid Yesuf Mohammed 
Published: August 2022

Abstract
This study has examined biomass and soil carbon stocks potential of different agroforestry practice home garden and woodlot and cultivated land in Tehuledere District, south wollo Zone, Ethiopia. A total of 60 sample plots (20 plots each) of 20m x 20m were randomly selected. AGB and BGB were calculated using available allometric equations. A total of 120 Soil samples (0–20 and 20–40 cm) were also collected from selected cultivated lands. The results showed that the total ecosystem carbon stock in home garden and woodlot agroforestry practice was estimated 100.4 and 72.9 Mg C ha− 1 respectively. SOC stock was significantly different among the studied land uses. The highest SOC stock was recorded in home garden agroforestry practice (94.2 Mg C ha− 1) followed by cultivated land (73 Mg C ha− 1) and woodlot agroforestry practice (68 Mg C ha− 1).The total ecosystem carbon stock ranged between (55 MgC ha− 1 -140 MgC ha− 1). Home garden holds the highest contribution for both biomass and SOC for the mean total ecosystem carbon accounting 84.3% for total SOC and the remaining accounts for total biomass contribution. Home garden agroforestry practice has the highest SOC stock. The study revealed that agroforestry practice enhance carbon stocks accumulation both in the biomass and soil besides the socioeconomic benefits over cultivated land hence, Agroforestry practice can be taken as potential climate change mitigation strategies in central highland of Ethiopia.
Rothia santali sp. nov., endophytic bacteria isolated from sandalwood (Santalum album L.) seedling
Authors: Tuikhar Ngangyola , Kirdat Kiran , Nair Gayatri , N. Manjula K. , Thorat Vipool , P. Swetha , Gowda Kavya , Sathe Shivaji , Sundararaj R. , Yadav Amit 
Published: August 2022

Abstract
A novel, ‘mustard yellow’ pigmented aerobic bacterial strain designated AR01T was isolated from hypocotyl tissue of a sandalwood seedling from Bangalore, India. The 16S rRNA gene of strain AR01T had the highest 98.97% sequence similarity with Rothia halotolerans YIM 90716T (KCTC 19172) followed by Rothia kristinae PM 129T (NBRC 15354T) (97.31%) and Rothia koreensis P31T (JCM 15915) (97.11%), respectively. The strain AR01T was coccoid-shaped, non-motile, non-spore-forming, oxidase-negative, and catalase-positive. The strain AR01T has a genome size of 3.31 Mb containing 2993 protein-coding genes including 48 tRNA and 10 rRNAs spread across 84 contigs. The genomic DNA G + C content was 71.77 mol%. The calculated dDDH was 31.10%, and the OrthoANI value was 85.27% compared to its closest related type strain Rothia halotolerans YIM 90716T. The predominant cellular fatty acids were C16:0 iso (30.04%), C15:0 anteiso (37.42%), and C17:0 anteiso (21.78%). The strain AR01T contains major polar lipids including diphosphatidylglycerol and phosphatidylglycerol. Based on the distinct physiological, biochemical characteristics and genotypic relatedness indicated that AR01T represents a novel species of the genus Rothia, for which the name Rothia santali sp. nov. (Type strain AR01T = MCC 4800T = JCM 35593T) is proposed.The GenBank/EMBL/DDBJ accession number for the reference 16S rRNA gene sequences of the strain AR01T is OM838448. The accession number of the whole-genome of AR01T is JANAFB000000000
Phantom-based evaluation of yttrium-90 datasets using Biograph Vision Quadra
Authors: Zeimpekis Konstantinos , Mercolli Lorenzo , Contri Maurizio , Sari Hasan , Prenosil George , Shi Kuangyu , Rominger Axel 
Published: August 2022

Abstract
Purpose
The image quality characteristics of a NEMA body phantom with yttrium-90 were evaluated on a total body PET/CT. The purpose of the study is to identify the optimized reconstruction setup for the imaging protocol of yttrium-90 radioembolization treatment on patients with malignant liver tumors.
Methods
Two NEMA IEC NU2 body phantoms were used for the study. One was filled with activity concentrations of 0.13 MBq/ml and 1.3 MBq/ml for the background and spheres respectively (ratio 1:10). The second one did not have any background concentration but had similar concentration for the spheres. Scan time was 50 minutes and the phantoms were positioned on the same bed and scanned simultaneously. The number of iterations varied from 2 up to 8 (5 subsets), the Gaussian filter from 2mm up to 6mm full-width-at-half-maximum. Images were reconstructed with a matrix of 440 x 440 and 220 x 220, with high sensitivity (HS) and ultra-high sensitivity (UHS) modes with the improved 3D scatter correction method. We simulated shorter acquisition times based on the list-mode data with 40, 30, 20, 10 and 5-minutes. The measurements included contrast recovery coefficients, signal-to-noise ratio, background variability and lung error. List mode data of a patient were rebinned in 1, 5, 10 and 20 minute time frames and evaluated.
Results
The recovery coefficient (RC) for the hot phantom was 0.36, 0.45, 0.53, 0.63, 0.68 and 0.84 for the spheres with diameters of 10, 13, 17, 22, 28, 37 mm respectively for UHS 2 iterations and a 220x220 matrix. The SNR was highest for 2 iterations, measured 11.7, 16.6, 17.6, 19.4, 21.9 and 27.7 and the lung error was 18%. The SNR was 19%, 20%, 24% and 31% higher for 2 iterations compared to 4 iterations for 20, 10, 5 and 1 minutes time frames respectively.
Conclusions
The long AFOV delivers images of Y-90 with the smallest sphere well visualized with a high RC. SNR for the patient data was maximum for 2 iterations and for 20-minutes acquisition while even 5-minutes acquisition time delivers images with no great loss of SNR (-20%). Further clinical investigation is recommended to check also the effects on post-treatment dosimetry validation.
HOAP: Node attribute completion of knowledge graph based on high-order neighbor attribute propagation
Authors: Xu Jiuyun , Zhang Wenjie , Duan Qiang , Li Shibao 
Published: August 2022

Abstract
Knowledge graph is the structural representation of the real-world facts, it mainly divides the knowledge into two forms of triples: (head entity, relation, tail entity) and (node, attribute, value). Thus, the attribute of entity is an indispensable part of knowledge graph, it plays an important role in enriching the concepts of entity and revealing entity characteristics. The existing research mostly focuses on mining the limited information contained in relations based on the low-order structure, ignoring the semantic information contained in attributes as well as the possible interaction and transitivity between nodes, and uses all neighbors in prediction, which involves nodes that have no contribution to the target node. In this paper, we study the problem of node attribute completion , and propose a method named High-Order Attribute Propagator (HOAP). This method aggregates the attribute information contains in the high-order neighbors of nodes, uses regression functions to calculate the interaction between each pair of attributes on different relationships. Moreover, we investigate the effect of the different strategies to select second-order neighbor on node attribute completion. Experiments on two general datasets show that the proposed method can predict the missing value of node attribute more accurately and effectively than the existing methods that only focus on low-order structure.
High prevalence of pre-diabetes and diabetes in asymptomatic patients attending an endocrine clinic in a tertiary care institute in Colombo
Authors: Ranathunga Ishara , Naveenkumar JP , Athukorala TG , Sumanatilleke M , Somasundaram NP 
Published: August 2022

Abstract
Background and ObjectivesThe prevalence of pre-diabetes and diabetes has risen exponentially in the recent past. Though the symptomatic patients frequently undergo testing for the diagnosis of the disease, asymptomatic individuals are not routinely subjected to diagnostic testing. Thus, data on asymptomatic people are still lacking. We have studied the prevalence of pre-diabetes and diabetes in asymptomatic subjects attending the Endocrinology clinic in a tertiary care institute in Sri Lanka. MethodsA descriptive cross sectional study was conducted from January to August 2020 at the Endocrinology Unit of the National Hospital of Sri Lanka. Systematic sampling was done recruiting non diabetic patients aged more than 40 years, attending the clinic for other endocrine diseases. After obtaining informed written consent, the data was collected using an interviewer administered questionnaire. Pre-diabetes or diabetes was diagnosed according to the ADA-2020 diagnostic criteria.ResultsThe study enrolled hundred and nine patients. The mean age was 53.9 years (range 40-76) and 90.8% were females. The mean weight was 62.1 (SD=11.3) kg and BMI was 26.6 (SD=4.6) kg/m-2. Forty six percent had a family history of first degree relative being affected with type 2 diabetes. All the patients were asymptomatic of classic symptoms of hyperglycemia. Patients were evaluated with fasting blood glucose levels and HbA1c values. Forty nine patients (45%) were diagnosed with diabetes or pre-diabetes with either one or both values being impaired range. Out of that, six patients (5.5%) were diagnosed with type 2 diabetes and 43 patients (39.4%) were diagnosed with pre-diabetes. Out of the patients diagnosed with pre-diabetes and diabetes (n=49), sixty four percent did not had a family history of first degree relative being affected with type 2 diabetes. Out of the pre-diabetes and diabetes patients 32% had their BMI < 25 kgm-2. ConclusionsThe prevalence of pre-diabetes and diabetes are much higher than expected in asymptomatic individuals. Hence, the likely patients should be regularly screened to diagnose asymptomatic phase of the disease. This is important as the prevalence has escalated in the immediate past, and diagnosing and treating early will improve long term outcome of the disease. Further large scale studies including community studies are needed to recognize the current prevalence and the rising trend both in urban and rural regions.
GSK-3β/β-catenin Pathway Played Curial Roles in the Regulation of NK Cell Cytotoxicity against Myeloma Cells
Authors: Jiang Yang , Zheng Chengyun , Ren Jing , Feng Xiumei , Kong Dexiao , Wang Yongjing , Xiao Juan , Jiang Wen , Feng Xiaoli , Liu Xiaoli , Li Ai , Sun Congcong , He Mingming , Li Bingen , Wang Juandong 
Published: August 2022

Abstract
The plasma cell malignancy multiple myeloma (MM) has been improved significantly by new drugs application and autologous hemopoietic stem transplantation. However, MM remains incurable. A number of studies have revealed an anti-MM effect of Nature killer (NK) cells, but their clinical efficacy was rather limited. Glycogen synthase kinase (GSK)-3β has been shown to have an antitumor function. To evaluate potential roles of GSK-3β inhibitor (TWS119) in the regulation of NK cell cytotoxicity against MM, we analyzed killing effect of NK cells on MM cells. Our results showed that in the presence of TWS119, NK cell line (NK-92) and in vitro expanded primary NK cells exhibited a significantly higher degranulation activity, expression of activating receptors, cellular cytotoxicity and cytokine secretion when they were exposed to MM cells. Mechanistic studies indicated that TWS119 treatment markedly upregulated RAB27A expression, a key molecule for NK cell degranulation, and induced colocalization of β-catenin with NF-κB in the nucleus of NK cells. More importantly, adoptive transfer of NK-92 cells significantly prolonged survival time of myeloma-bearing mice. In summary, our current novel findings suggest that targeting on GSK-3β through activation of β-catenin/NF-κB pathway maybe an important approach to improve therapeutic efficacy of NK cells transfusion for MM.
Rapid degradation of two antifouling agents in seawater as affected by plankton and dissolved oxygen
Authors: Xu Yongjian , Wang Yongshuai , Lu Guangming , Yang Chengxue 
Published: August 2022

Abstract
Environment-friendly antifouling agents are the key research and development directions for marine antifouling paints. The characteristics for excellent performance by an antifouling agent are a good antifouling effect, long-period function, and little impact on the aquatic environment. Based on comparison with 4,5-dichloro-2-octyl-4-isothiazolin-3-ketone (DCOIT), the degradation of bio-based 2,5-furandiformaldehyde oxime (E-DFFD) and bio-based 2,5-furandimedoxime copper (II) complex (E-DFFD-Cu), which are two new antifouling agents developed by our laboratory, was analysed in seawater environment, and their environment-friendly characteristics were investigated via biodegradation experiments. The results showed that the presence of plankton and a high concentration of dissolved oxygen (DO) could greatly promote their degradation rate and amount, resulting in rapid degradation in seawater, i.e., with aeration, 12.23% and 32.23% of the agents degraded in natural seawater after 7 days, respectively, (as compared to 5.50 and 14.81% without aeration), the contrast was similarly apparent in sterile seawater which shows 9.93% and 29.61% decrease after filtration and sterilization. The half-life periods of E-DFFD-Cu and E-DFFD in natural seawater at 22°C were 12.4 and 34.7 days, respectively. Furthermore, the influence of the structure and composition of different plankton groups on their degradation amount and rate was significantly different, and the dominant biological groups for biodegradation changed when the antifouling agent was modified and derived. Zooplankton was the main contributor to degradation of E-DFFD, accounting for 80.84% of its biodegradation and 68.35% of its total degradation. Phytoplankton was the main contributor to E-DFFD-Cu degradation, accounting for 53.24% of the total biological contribution, followed by bacteria (31.47%). Bacteria accounted for 50.56% of the total biological contribution to DCOIT degradation followed by zooplankton (27.23%), and abiotic factors accounted for more than 10% of its total degradation. Nonetheless, abiotic factors had little effect on the degradation of E-DFFD-Cu and E-DFFD. This study evaluated the contribution of marine organisms to the biodegradation and the influence of DO to degradation of two environment-friendly antifouling agents in natural sweater.
Effect of thermo-mechanical properties of concrete on the temperature field in mass concrete
Authors: Pham Duc-Phong , Nguyen Trong-Chuc , Vu Kim-Dien 
Published: August 2022

Abstract
Massive concrete structures' fissures are affected by the heat of hydration. There are many factors affecting the formation of temperature and stress fields such as construction technology, the materials used, and the surrounding environment. In this study, the author investigates how the volumetric weight, thermal conductivity, and specific heat capacity of concrete affect the maximum temperature in massive concrete buildings. The study's findings and suggestions were then presented.
Removal of Pb (II) and Cd (II) Ions by MnFe2O4@SiO2@VTMS Nanocomposites Hydrogel from Aqueous Solutions
Authors: Ghobadifar Vahid , Marandi Gholam Bagheri , Kurdtabar Mehran , Bardajee Ghasem Rezanejade 
Published: August 2022

Abstract
In this work, magnetic nanocomposite hydrogel was produced via grafting copolymerization of acrylic acid (AA) and acrylamide (AAm) in the presence of MnFe2O4@SiO2@Vinyltrimethylsilane (VTMS) as a cross-linking agent. To effectively absorb Pb (II) and Cd (II) from an aqueous solution, the prepared magnetic nanocomposite hydrogel was applied. XRD, VSM, FT-IR, SEM, EDS, and TEM VSM, SEM, TEM, EDS, FT-IR, and XRD spectroscopic methods validated the structure of the prepared nanocomposite hydrogel. In addition, thermal characteristics were evaluated by TGA and DTG. The features that influence the absorption of heavy metal ions include pH solution, treatment time, starting concentration of ions, temperature, and sorbent quantity experimented. Employing Langmuir, Freundlich, and Temkin, the adsorption isotherm was investigated at various temperatures. The adsorption data best fitted The Langmuir isotherm model. The absorption kinetics models such as intraparticle, pseudo-first-order, pseudo-second-order in metal ion solutions of 25, 50, 100, and 150 mg/L-1 were studied. The absorption results were well explained by pseudo-first-order model. The maximal absorption capacities of magnetic nanocomposite hydrogel for Pb (II) and Cd (II) elimination from a 150 mg/L-1 metal solution were 131 and 126 mg/g, respectively. The absorbent was employed effectively for four cycles of adsorption and desorption. Therefore, the nanocomposite hydrogel examined in this work may be used for various water filtration purposes, notably for the elimination of toxic metals.
The novel strategy for enhancing growth and lipid accumulation in C.vulgaris microalgae cultured in dairy wastewater by monochromatic LEDs and melatonin
Authors: Samani Mohammad Sadegh Maleki , Mansouri Hakimeh 
Published: August 2022

Abstract
The present study investigated the effects of melatonin hormone and monochromatic light-emitting diodes (LEDs) on the biomass productivity and lipid accumulation of C.vulgaris green microalgae. Four monochromatic LEDs were applied individually or simultaneously with melatonin in dairy wastewater. For reducing the cultivation costs dairy wastewater is utilized for the culture medium. In free melatonin samples, the maximum biomass productivity was observed under red, blue, green and white LEDs. The biomolecules including protein, carbohydrate, lipid and pigment increased by monochromatic LEDs application compared to white LEDs. Melatonin application in culture medium increased parameters compared to free melatonin samples. The simultaneous treatment of red LED with concentration of 10 µM melatonin increased the biomass productivity and biomolecules by approximately 200% compared to control samples. In addition, the fatty acid profile improved under simultaneous treatment. The MUFAs and PUFAs increased by 22% and 8% compared to control. The SFAs decreased from 85.58% in control samples to 56.93 under red wavelength and melatonin hormone. These findings demonstrated that the monochromatic LEDs application and exogenous melatonin is the novel economical treatments for C.vulgaris microalgae cultivation, which increase biomass production and biomolecules accumulation.
Mechanical Properties and Micro-Structure of Expansive Soil Stabilized by Graphene Oxide Modified Cement
Authors: Zhang Chen , Zhu Zhiduo , Wang Wei , Shao Li , Wan Yu , Huo Wangwen 
Published: August 2022

Abstract
It is essential to improve the swelling-shrinkage properties and mechanical strength of expansive soil in engineering. A series of unconsolidated-undrained triaxial tests were conducted to investigate the stabilization of graphene oxide (GO) modified cement in expansive soil, the GO contents were 0.05%, 0.1%, 0.15% and 0.2%, respectively. Results showed that (1) With the addition of GO, the deviatoric stress-strain curve of cement-stabilized expansive soil (CSS) change from weak softening to strong softening. (2) The compressive strength, shear strength, toughness and stiffness of GOCS were significantly better than CSS. (3) Microscopic tests showed that GO as a template promoted the hydration of cement and filled the pores of soil sample, making the internal structure of CSS more compact. Consequently, GO modified cement can better improve the mechanical properties and micro-structure of expansive soil, and it is feasible to apply GOCS to the engineering construction.
Association between Prebiotics, Probiotics and Changes in Body Composition, Physique and Metabolic Products in a Longitudinal Intervention Study
Authors: Hassan Nayera E. , El-Masry Sahar A. , Shebini Salwa M. El , Ahmed Nihad H. , Mehanna Nayra Sh. , Magdy Mai , Amine Darine , Hashish Adel , Selim Mohamed , Afify Mahmoud A.S. , Alian Khadija 
Published: August 2022

Abstract

Background The relationship between gut microbiota and obesity has recently been an important subject for research as the gut microbiota is thought to affect body homeostasis including body weight and composition, making the intervention with pro and prebiotics an intelligent possible way for obesity management. Aim To evaluate the effect of hypo caloric high fiber regimen, physical exercise and probiotic supplementation on the improvement of health, body composition and physique among obese Egyptian women. Methods The enrolled 58 women, in this longitudinal follow up intervention study; followed a weight loss eating regimen (prebiotic), included low-carbohydrate high-fiber high-protein dietary pattern with decreased energy intake. They additionally received daily probiotic supplement in form of yogurt, and were instructed to exercise regularly for 3 months. Anthropometric measurements, body composition, laboratory investigations and microbiota analysis were obtained before and after the 3 months weight loss program. Results Statistically highly significant differences in the anthropometry, body composition parameters: and obesity-related biomarkers (Leptin, ALT and AST) between the pre and post follow up measurements at the end of the study as they were all decreased. The prebiotic and probiotic supplementation induced statistically highly significant alterations in the composition of the gut microbiota with increased relative abundance of Lactobacillus, Bifidobacterium and Bacteroidetes and decreased relative abundance of Firmicutes and Firmicutes/ Bacteroidetes Ratio. Conclusion Hypo caloric high fiber regimen diet with probiotics has a positive impact on body composition and is effective for weight loss normalizing serum Leptin and AST.