bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influência da aplicação foliar de silício no desenvolvimento e produtividade do milho sob déficit hídrico no semiárido piauiense
Authors: Araújo Vinícius de Sousa , Sousa Thalma Katiani Rodrigues  de , Nobre Rafael de Sousa , Santos Cássio de Moura , Negreiros Katriny Kellen da Silva , Carvalho Ana Clara Caminha de , Veloso Fernanda de Sousa , Veloso Ronilson Carvalho , Rezende Jefrejan Souza 
Published: April 2022

O silício tem sido associado a efeitos benéficos para as plantas como tolerância a déficit hídrico, stress salinos e menor transpiração. Este trabalho objetivou-se avaliar o efeito da aplicação de silício no desenvolvimento e produtividade do milho submetido a diferentes períodos de déficit hídrico no Semiárido piauiense. O delineamento experimental utilizado foi o de blocos casualizados, em arranjo fatorial 4x2, formados pela combinação de quatro doses de silício (0, 50, 100 e 200% da dose recomendada) e duas condições de déficit hídrico (moderado e severo), com quatro repetições. A dose recomendada foi de 1,0 L ha-1 do silicato, conforme o fabricante. A variedade utilizada foi a super precoce BRS Gorutuba. Cada parcela consistiu em quatro fileiras de 4,0 m espaçadas a 0,80 m uma da outra, considerando área útil às fileiras centrais e as extremas como bordadura. Os dados foram submetidos à análise de variância pelo teste F. Para a verificação da dose ótima de silício, para cada intensidade de stress foi aplicada à análise de regressão polinomial (P<0,05). Houve efeito significativo da interação para as variáveis massa fresca da parte aérea, massa seca da parte aérea e produtividade. As doses de 0,84 e 0,55 L ha-1 de silício foram as mais indicadas para o déficit moderado e severo, respectivamente. Doses acima de 1L ha-1 proporcionaram redução do crescimento e produtividade do milho.
Magnetic Surface Molecularly Imprinted Polymer for Selective Adsorption of 4-Hydroxycoumarin
Authors: Kuang Yi , Xia Yunlong , Wang Xing , Rao Qingqing , Yang Shengxiang 
Published: April 2022

4-hydroxyl coumarin (HC), an important intermediate during the synthesis procedure of rodenticide and anti-cardiovascular drug, shows highly medicinal value and economic value. To achieve the efficient adsorption of HC from natural biological samples, a novel magnetic surface molecularly imprinted polymer (HC/SMIPs) was constructed by employing methacrylic acid (MAA) as functional monomer, organic silane modified magnetic particles as matrix carrier and HC as template molecule. Due to the numerous specific imprinted cavities on the HC/SMIPs, the maximum adsorption capacity of HC/SMIPs for 4-hydroxycoumarin could reach to 22.78 mg g−1 within 20 min. In addition, HC/SMIPs exhibited highly selective adsorption for 4-hydroxycoumarin compared with other active drug molecules (osthole and rutin) and showed excellent regeneration performance. After 8 cycles of adsorption-desorption tests, the adsorption capacity of HC/SMIPs just slightly decreased by 6.64%. The efficient selective removal and easy recycle of 4-hydroxycoumarin from biological samples by HC/SMIPs made a highly promising to advance the application of imprinting polymers in complex practical environments.
Robust α-Fe2O3@TiO2 Core–Shell Structures With Tunable Buffer Chambers for High-Performance Lithium Storage
Authors: Pian Chunyuan , Peng Weichao , Ren Haoyu , Ma Chao , Su Yun , Ti Ruixia , Chen Xiuyu , Zhu Lixia , Liu Jingjing , Sun Xinzhi , Wang Bin , Niu Bingxuan , Wu Dapeng 
Published: April 2022

α-Fe2O3 has high potential energy storage capacity and can serve as a green and low-cost anode material for lithium-ion batteries. However, α-Fe2O3 suffers large volume expansion and pulverization. Based on DFT calculations, TiO2 can effectively maintain the integrity of the crystal structure during the discharge/charge process. Well-defined cubic α-Fe2O3 is coated with a TiO2 layer using the hydrothermal method with the assistance of oxalic acid surface treatment, and then α-Fe2O3@TiO2 with tunable buffer chambers is obtained by altering the hydrochloric acid etching time. With the joint efforts of the buffer chamber and the robust structure of the TiO2 layer, α-Fe2O3@TiO2 alleviates the expansion of α-Fe2O3 during the discharge/charge process. The optimized sample (FT-1h) achieves good cycling performance. The reversible specific capacity remains at 893.7 mA h g-1, and the Coulombic efficiency still reaches up to 98.47% after 150 cycles at a current density of 100 mA g−1. Furthermore, the reversible specific capacity can return to 555.5 mA h g−1 at 100 mA g−1 after cycling at a high current density. Hence, the buffer chamber and the robust TiO2 layer can effectively improve the cycling stability and rate performance of α-Fe2O3.
Coronary Atherosclerotic Disease and Cancer: Risk Factors and Interrelation
Authors: Li Jinjing , Zhao Jieqiong , Lei Yonghong , Chen Yan , Cheng Miaomiao , Wei Xiaoqing , Liu Jing , Liu Pengyun , Chen Ruirui , Yin Xiaoqing , Shang Lei , Li Xue 
Published: April 2022

BackgroundIn our clinical work, we found that cancer patients were susceptible to coronary atherosclerotic heart disease (CAD). However, less is known about the relationship between CAD and cancer. The present study aimed to identify the risk factors for CAD and cancer, as well as the relationship between CAD and cancer.MethodsIn this retrospective study, 1600 patients between January 2012 and June 2019 were enrolled and divided into groups according to whether they had CAD or cancer. Single-factor and multivariate analysis methods were applied to examine the risk factors for CAD and cancer.Results(1) Cancer prevalence was significantly higher in patients with CAD than in patients without CAD (47.2 vs. 20.9%). The prevalence of CAD in cancer and non-cancer patients was 78.9 and 52.4%, respectively. (2) Multivariable logistic regression showed that patients with cancer had a higher risk of developing CAD than non-cancer patients (OR: 2.024, 95% CI: 1.475 to 2.778, p &lt; 0.001). Respiratory (OR: 1.981, 95% CI: 1.236–3.175, p = 0.005), digestive (OR: 1.899, 95% CI: 1.177–3.064, p = 0.009) and urogenital (OR: 3.595, 95% CI: 1.696–7.620, p = 0.001) cancers were significantly associated with a higher risk of CAD compared with no cancer. (3) Patients with CAD also had a higher risk of developing cancer than non-CAD patients (OR = 2.157, 95% CI: 1.603 to 2.902, p &lt; 0.001). Patients in the Alanine aminotransferase (ALT) level ≥ 40 U/L group had a lower risk of cancer than patients in the ALT level &lt; 20 U/L group (OR: 0.490, 95% CI: 0.333–0.722, p &lt; 0.001). (4) An integrated variable (Y = 0.205 × 10–1 age − 0.595 × 10–2 HGB − 0.116 × 10–1 ALT + 0.135 FIB) was identified for monitoring the occurrence of cancer among CAD patients, with an AUC of 0.720 and clinical sensitivity/specificity of 0.617/0.711.Conclusion(1) We discovered that CAD was an independent risk factor for cancer and vice versa. (2) Digestive, respiratory and urogenital cancers were independent risk factors for CAD. (3) We created a formula for the prediction of cancer among CAD patients. (4) ALT, usually considered a risk factor, was proven to be a protective factor for cancer in this study.
Determinants of Non-calcified Low-Attenuation Coronary Plaque Burden in Patients Without Known Coronary Artery Disease: A Coronary CT Angiography Study
Authors: Yamaura Hiroki , Otsuka Kenichiro , Ishikawa Hirotoshi , Shirasawa Kuniyuki , Fukuda Daiju , Kasayuki Noriaki 
Published: April 2022

BackgroundAlthough epicardial adipose tissue (EAT) is associated with coronary artery disease (CAD), it is unclear whether EAT volume (EAV) can be used to diagnose high-risk coronary plaque burden associated with coronary events. This study aimed to investigate (1) the prognostic impact of low-attenuation non-calcified coronary plaque (LAP) burden on patient level analysis, and (2) the association of EAV with LAP volume in patients without known CAD undergoing coronary computed tomography angiography (CCTA).Materials and MethodsThis retrospective study consisted of 376 patients (male, 57%; mean age, 65.2 ± 13 years) without known CAD undergoing CCTA. Percent LAP volume (%LAP, &lt;30 HU) was calculated as the LAP volume divided by the vessel volume. EAT was defined as adipose tissue with a CT attenuation value ranging from −250 to −30 HU within the pericardial sac. The primary endpoint was a composite event of death, non-fatal myocardial infarction, and unstable angina and worsening symptoms requiring unplanned coronary revascularization &gt;3 months after CCTA. The determinants of %LAP (Q4) were analyzed using a multivariable logistic regression model.ResultsDuring the follow-up period (mean, 2.2 ± 0.9 years), the primary endpoint was observed in 17 patients (4.5%). The independent predictors of the primary endpoint were %LAP (Q4) (hazard ratio [HR], 3.05; 95% confidence interval [CI], 1.09–8.54; p = 0.033] in the Cox proportional hazard model adjusted by CAD-RADS category. Cox proportional hazard ratio analysis demonstrated that %LAP (Q4) was a predictor of the primary endpoint, independnet of CAD severity, Suita score, EAV, or CACS. The independent determinants of %LAP (Q4) were CACS ≥218.3 (p &lt; 0.0001) and EAV ≥125.3 ml (p &lt; 0.0001). The addition of EAV to CACS significantly improved the area under the curve (AUC) to identify %LAP (Q4) than CACS alone (AUC, EAV + CACS vs. CACS alone: 0.728 vs. 0.637; p = 0.013).ConclusionsCCTA-based assessment of EAV, CACS, and LAP could help improve personalized cardiac risk management by administering patient-suited therapy.
A Novel Risk Score to Predict In-Hospital Mortality in Patients With Acute Myocardial Infarction: Results From a Prospective Observational Cohort
Authors: Li Lulu , Zhang Xiling , Wang Yini , Yu Xi , Jia Haibo , Hou Jingbo , Li Chunjie , Zhang Wenjuan , Yang Wei , Liu Bin , Lu Lixin , Tan Ning , Yu Bo , Li Kang 
Published: April 2022

ObjectivesThe aim of this study was to develop and validate a novel risk score to predict in-hospital mortality in patients with acute myocardial infarction (AMI) using the Heart Failure after Acute Myocardial Infarction with Optimal Treatment (HAMIOT) cohort in China.MethodsThe HAMIOT cohort was a multicenter, prospective, observational cohort of consecutive patients with AMI in China. All participants were enrolled between December 2017 and December 2019. The cohort was randomly assigned (at a proportion of 7:3) to the training and validation cohorts. Logistic regression model was used to develop and validate a predictive model of in-hospital mortality. The performance of discrimination and calibration was evaluated using the Harrell’s c-statistic and the Hosmer-Lemeshow goodness-of-fit test, respectively. The new simplified risk score was validated in an external cohort that included independent patients with AMI between October 2019 and March 2021.ResultsA total of 12,179 patients with AMI participated in the HAMIOT cohort, and 136 patients were excluded. In-hospital mortality was 166 (1.38%). Ten predictors were found to be independently associated with in-hospital mortality: age, sex, history of percutaneous coronary intervention (PCI), history of stroke, presentation with ST-segment elevation, heart rate, systolic blood pressure, initial serum creatinine level, initial N-terminal pro-B-type natriuretic peptide level, and PCI treatment. The c-statistic of the novel simplified HAMIOT risk score was 0.88, with good calibration (Hosmer–Lemeshow test: P = 0.35). Compared with the Global Registry of Acute Coronary Events risk score, the HAMIOT score had better discrimination ability in the training (0.88 vs. 0.81) and validation (0.82 vs. 0.72) cohorts. The total simplified HAMIOT risk score ranged from 0 to 121. The observed mortality in the HAMIOT cohort increased across different risk groups, with 0.35% in the low risk group (score ≤ 50), 3.09% in the intermediate risk group (50 &lt; score ≤ 74), and 14.29% in the high risk group (score &gt; 74).ConclusionThe novel HAMIOT risk score could predict in-hospital mortality and be a valid tool for prospective risk stratification of patients with AMI.Clinical Trial Registration[https://clinicaltrials.gov], Identifier: [NCT03297164].
Hyperuricemia Is Associated With the Risk of Atrial Fibrillation Independent of Sex: A Dose-Response Meta-Analysis
Authors: Xiong Jianhua , Shao Wen , Yu Peng , Ma Jianyong , Liu Menglu , Huang Shan , Liu Xiao , Mei Kaibo 
Published: April 2022

Background:Conflicting findings of the association between serum uric acid (SUA) and atrial fibrillation (AF) have been reported in both men and women. The sex-specific associations between SUA and the risk of AF are unclear, although hyperuricemia is independently associated with the risk of AF. We performed this meta-analysis to assess the sex-specific effect of SUA on the risk of AF.MethodsThe PubMed, EMBASE, and Cochrane Library databases were searched up to October 3, 2021, for studies that reported sex-specific associations of SUA levels with AF. Linear relationships were assessed by the generalized least squares trend estimation. This study was registered with PROSPERO (42020193013).ResultsTen eligible studies with 814,804 participants (415,779 men and 399,025 women) were identified. In the category analysis, high SUA was associated with an increased risk of AF in both men (OR: 1.42; 95% CI, 1.18–1.71, I2 = 34%) and women (OR: 2.02; 95% CI, 1.29–3.16, I2 = 70%). In the dose-response analysis, for each 60 μmol/L (1 mg/dL) increase in the SUA level, the risk of AF increased by 15% (OR: 1.15; 95% CI, 1.07–1.25, I2 = 74%) in men and 35% (OR: 1.35; 95% CI, 1.18–1.53, I2 = 73%) in women. There was a borderline difference in the impact of SUA on the risk of AF between men and women (P for interaction = 0.05). A significant linear relationship between SUA and the risk of AF was observed in men (P for non-linearity = 0.91) and women (P for non-linearity = 0.92).ConclusionsThis study suggested that there was a significant linear relationship between SUA and the risk of AF among men and women, with a higher risk estimate for women. Additional trials are required to assess the effect of reduced SUA therapy on AF incidence.Systematic Review Registrationhttps:www.crd.york.ac.uk/PROSPERO/, identifier: CRD 42020193013.
Establishment and Validation of a Non-invasive Diagnostic Nomogram to Identify Heart Failure in Patients With Coronary Heart Disease
Authors: Tan Juntao , He Yuxin , Li Zhanbiao , Xu Xiaomei , Zhang Qinghua , Xu Qian , Zhang Lingqin , Xiang Shoushu , Tang Xuewen , Zhao Wenlong 
Published: April 2022

BackgroundHeart failure (HF) is an end-stage manifestation of and cause of death in coronary heart disease (CHD). The objective of this study was to establish and validate a non-invasive diagnostic nomogram to identify HF in patients with CHD.MethodsWe retrospectively analyzed the clinical data of 44,772 CHD patients from five tertiary hospitals. Univariate logistic regression analyses and least absolute shrinkage and selection operator (LASSO) regression analyses were used to identify independent factors. A nomogram based on the multivariate logistic regression model was constructed using these independent factors. The concordance index (C-index), receiver operating characteristic (ROC) curves, calibration curves, decision curve analysis (DCA), and clinical impact curves (CIC) were used to evaluate the predictive accuracy and clinical value of this nomogram.ResultsThe predictive factors in the multivariate model included hypertension, age, and the total bilirubin, uric acid, urea nitrogen, triglyceride, and total cholesterol levels. The area under the curve (AUC) values of the nomogram in the training set, internal validation set, external validation set1, and external validation set2 were 0.720 (95% CI: 0.712–0.727), 0.723 (95% CI: 0.712–0.735), 0.692 (95% CI: 0.674–0.710), and 0.655 (95% CI: 0.634–0.677), respectively. The calibration curves indicated that the nomogram had strong calibration. DCA and CIC indicated that the nomogram can be used as an effective tool in clinical practice.ConclusionThe developed predictive model combines the clinical and laboratory factors of patients with CHD and is useful in individualized prediction of HF probability for clinical decision-making during treatment and management.
Environmental Flows to Estuaries and Coastal Lagoons Shape the Salinity Gradient and Generate Suitable Fish Habitat: Predictions From the Coorong, Australia
Authors: Brookes Justin D. , Huang Peisheng , Zhai Sherry Y. , Gibbs Matthew S. , Ye Qifeng , Aldridge Kane T. , Busch Brendan , Hipsey Matthew R. 
Published: April 2022

Freshwater flows to estuaries shape habitat, transport nutrients to drive productivity, and generate a salinity gradient that impacts water quality and provides spawning cues for fish. The aim of this study was to quantify how environmental flows improved outcomes for a coastal lagoon system (the Coorong, South Australia), considering the export, and prevention of ingress, of salt from the system, and the increased available habitat for key fish biota. A hydrodynamic model was used to simulate salinity and water temperature, and to determine the salt exchange between the Coorong and ocean for the observed conditions with environmental water release included. Scenario simulations showed that maintaining river flow is shown to arrest salt intrusion from the ocean into the Coorong. Without environmental water, the net import of salt into the Coorong would have been considerably greater, ranging between 1.86 million tonnes in 2018–19 to approximately 2.33 million tonnes in 2019–20. The fresher conditions created by environmental water provision supported a considerable expansion of suitable fish habitat area, derived from a simple habitat index based on salinity and water temperature. Without environmental water the habitat suitable for mulloway would have contracted by 38% over the 3 year investigation period. A similar trend is evident for black bream, Tamar goby, greenback flounder, yelloweye mullet, congolli and smallmouth hardyhead. The results highlighted the importance of cumulative benefits from delivering environmental water over multiple years, with different results obtained if the environmental water provided regularly or just focused over a single year. The approach used in this work to relate hydrological changes from water management to indicators of habitat suitability through changes to physical attributes provides information to inform the evaluation of environmental watering, as well as a tool to support future decision making to maximise the benefits from this precious resource.
Novel Silane Crosslinked Chitosan Based Electrospun Nanofiber for Controlled Release of Benzocaine
Authors: Naz Mehwish , Jabeen Sehrish , Gull Nafisa , Ghaffar Abdul , Islam Atif , Rizwan Muhammad , Abdullah Huda , Rasool Atta , Khan Shahzad , Khan Rafi 
Published: April 2022

Nanofibers mats of chitosan (CTS)/polyvinyl alcohol (PVA)/halloysite nanoclay and drug loaded CTS/PVA/halloysite nanoclay//3-glycidyoxypropyl trimethoxysilane were fabricated using the electrospinning method. Electrospun nanofiber samples were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). FTIR confirmed the chemical and physical bonding among ingredients such as CTS, PVA, nanoclay and crosslinker in the nanofibers. SEM images showed the development of uniform nanofibers. The average nanofiber diameter was observed in the range of 50–200 nm. Antimicrobial activity was examined againstE. coliandS. aurusbacteria. The results obtained indicated that all nanofiber samples showed significant antimicrobial activity against the Gram-positive as well as Gram-negative bacteria. TGA results indicated that the thermal stability of nanofibers increased with the addition of the crosslinker. The drug release was studied in phosphate buffer saline (PBS) solution (pH 7.4) at 37°C and was released from nanofibers in 2.5 h. Hence, these prepared nanofibers can be used in medication where the drug is required for a long duration.
Fluorescence Quenching of Graphene Quantum Dots by Chloride Ions: A Potential Optical Biosensor for Cystic Fibrosis
Authors: Ifrah Zahid , Shah Rukh Abbas , Muhammad Nauman Sharif , Maryam Shahid , Rahat Ullah 
Published: April 2022

Cystic fibrosis is a genetic disorder caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that encodes an ABC transporter-class ion channel protein, resulting in sticky and thick mucus secretion which clogs the airways and leads to respiratory failure and other complications. It also results in higher chloride ions (Clˉ) in body fluids. Cystic fibrosis is generally detected using the sweat chloride test and ion exchange chromatography, which are lab restricted. Therefore, there is a dire need to develop portable assays to monitor circulatory changes (Clˉ ion detection) to detect CF at the point of care. In this work, fluorescence quenching of graphene quantum dots (GQDs) was used as a property of the optical sensor for chloride ion detection. GQDs were synthesized by varying the carbonizing temperature and time, and then their optical and fluorescence (FL) quenching was investigated upon exposure to chloride ions in comparison with different ionic species. GQDs synthesized at 160°C for 50 min were chosen as they displayed the highest fluorescence. The morphological and optical characterization confirmed the preparation of 12–15 nm GQDs, which were amorphous in nature with the peak emission observed at 462 nm when excited at 370 nm. The fluorescence quenching response of GQDs with Clˉ ions displayed linearity up to 100 mM with a correlation coefficient of 0.98 and the lowest detection limit of approximately 10 mM Clˉ ions.
Global Research Status and Trends in Venous Thromboembolism After Hip or Knee Arthroplasty From 1990 to 2021: A Bibliometric Analysis
Authors: Song Wei , Ma Tao , Cheng Qianyue , Wen Pengfei , Wu Jiayuan , Hao Linjie , Zhang Binfei , Wang Yakang , Wang Qiuyuan , Zhang Yumin 
Published: April 2022

BackgroundVenous thromboembolism (VTE) after hip or knee arthroplasty has attracted increasing attention over the past few decades. However, there is no bibliometric report on the publications in this field. The purpose of this study was to analyze the global research status, hotspots, and trends in VTE after arthroplasty.MethodsAll articles about VTE research after hip or knee arthroplasty from 1990 to 2021 were retrieved from the Web of Science Core Collection database. The information of each article including citation, title, author, journal, country, institution, keywords, and level of evidence was extracted for bibliometric analysis.ResultsA total of 1,245 original articles from 53 countries and 603 institutions were retrieved. The USA contributed most with 457 articles, followed by England and Canada. McMaster University in Canada was the leading institution for publications. The journals with the highest output and citation were the Journal of Arthroplasty and the Thrombosis and Haemostasis, respectively. The median number of citations was significantly different among the levels of evidence (F = 128.957, P &lt; 0.001). The research hotspots switched from VTE diagnosis and heparin to factor Xa inhibitors (fondaparinux, rivaroxaban, apixaban) and direct thrombin inhibitors (dabigatran etexilate, ximelagatran), and finally to aspirin, risk factor studies, which can be observed from the keyword analysis and co-cited reference cluster analysis.ConclusionsThis study observed an increasing trend of research articles on VTE after arthroplasty. Publications with higher levels of evidence gained further popularity among researchers and orthopedic surgeons. Additionally, individualized VTE prevention and the development of new, safe, effective, and inexpensive oral agents would be emerging trends in the future.