bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality 4.0 conceptualisation: an emerging quality management concept for manufacturing industries
Authors: Maganga Deusdedith Pastory , Taifa Ismail W.R. 
Published: February 2022

PurposeQuality 4.0 refers to a modern quality management approach that uses Industry 4.0 technologies, integration and digitalisation. This research explores the current understandings of Quality 4.0 in various publications. The focus is on Quality 4.0 concepts or explanations, available models, motivation and readiness factors for adoption, enablers and technologies that can be leveraged.Design/methodology/approachA qualitative approach was deployed to collect the findings. This paper employs bibliometric, scientometric and visual analytic tools to identify and analyse articles from Scopus, Web of Science (WOS), Google Scholar databases and other sources such as ScienceDirect and Taylor and Francis.FindingsThe bibliometric results revealed that Quality 4.0 publications began in 2016 and increased dramatically in 2020 and 2021, with India leading the way while scientometric analysis found no clear definition of Quality 4.0 hitherto. However, several authors have defined the concept of Quality 4.0, arguing that it is characterised by digitalisation and integration, Industry 4.0 technologies applications and big data management. Some of the Quality 4.0 models published in the theoretical underpinnings include total quality management (TQM) in the basis of Industry 4.0 model, the European Foundation for quality management model, Quality 4.0 model combining operational technology (OT) and information technology (IT) through digital transformation and the LSN Research eleven axes of Quality 4.0 model. The research highlights key enablers of Quality 4.0 adoption, such as enabling technologies, big data capability, skilled and competent workers, collaboration and leadership support.Research limitations/implicationsThe findings can benefit Quality 4.0 researchers and practitioners on the available Quality 4.0 models, motivation and readiness factors for Quality 4.0 adoption, enablers and leveraged technologies in Quality 4.0.Originality/valueThis study attempted to explore the current understandings of Quality 4.0 concepts to sediment these emerging quality management concepts for manufacturing industries.
The ethics of marriage in American evangelicalism
Authors: Brenner Suzanne 
Published: February 2022

AbstractThe idea that marriage should be treated as a site of pious ethical work is widespread in conservative Christian discourse. This article considers how and why conservative American evangelicals have come to regard the everyday routines of heterosexual marriage as potential forms of religious labour that can cultivate robust Christian subjectivities along with successful conjugal relationships. It argues that the notion of pious marital work was strongly shaped by the secular culture of therapeutic counselling and self‐help that developed during the twentieth century. While pious ethics and secular, everyday ethics are often seen as distinct, this historical perspective illuminates the modern coevolution of secular and conservative religious conceptions of marriage, revealing how each has linked marital work to personal as well as societal redemption.
Enhanced bioavailability and anti‐hyperglycemic activity of young apple polyphenols by complexation with whey protein isolates
Authors: Li Dan , Yang Yongli , Yang Xi , Wang Zichao , Yao Xiaolin , Guo Yurong 
Published: February 2022

AbstractThis study aims to evaluate the effects of complexation of whey protein isolate (WPI) and young apple polyphenols (YAP) on the bioavailability and anti‐hyperglycemic activity of YAP. Two types of WPI‐YAP complexes were fabricated by mixing WPI with YAP at 25℃ (WPI‐YAP) and 90℃ (WPI‐YAP‐H), respectively. The intermolecular interactions between WPI and YAP were investigated by fluorescence spectroscopy and circular dichroism analyses. The in vitro bioaccessibility and bioavailability of YAP were determined using a simulated gastrointestinal digestion and human Caco‐2 cells model. It was found that the total polyphenols transport efficiency was improved from 39.8% (YAP) to 48.2% (WPI‐YAP) and 56.1% (WPI‐YAP‐H), indicating that the bioavailability of YAP was improved by complexation with WPI. Besides, after complexation with WPI, YAP displayed an improved in vivo effect on alleviating the increase in postprandial blood glucose level than the pure YAP, with WPI‐YAP‐H showing a better effect. This finding indicates that co‐complexation of YAP with WPI is an effective way to improve the functionality of YAP, and the WPI‐YAP complexes are also expected to have potential application in designing YAP‐containing functional foods.Practical ApplicationThe research provided a method to improve the bioavavibility of polyphenols, and the WPI‐YAP complex can be developed in designing polyphenols related functional foods.
Pharmacological effects and safety of Andrographis paniculata (Burm.f.) Nees
Authors: Tian Jingzhuo , Li Chunying , Meng Jing , Wang Lianmei , Tong Yan , Zhao Yong , Yi Yan , Zhang Yushi , Xian Zhong , Pan Chen , Liu Suyan , Han Jiayin , Liang Aihua 
Published: February 2022

AbstractAndrographis paniculata (Burm.f.) Nees (AP) is widely used in most Asian and some Western countries. However, its main effects and underlying pharmacological mechanism have not been thoroughly characterized, and its safety has not been sufficiently investigated. The present study aimed to predict and visualize the potential targets and pathways, clarify the main pharmacological effects, and investigate the toxicological properties of AP extract (APE).First, ingenuity pathway analysis (IPA) was performed to directly predict AP's therapeutic targets and pathways; main pharmacological effects of AP were speculated based on IPA results and confirmed by pharmacodynamics experiments. Rodent toxicity studies were then performed through administration of a single dose of 10 g/kg or daily doses of 2, 1, or 0.5 g/kg for 8 weeks to evaluate the safety of APE, and a similar repeated‐dose study was performed using dogs with doses equal to half of the above‐mentioned doses. Thus, repeated‐dose toxicity studies were performed with both rodents and nonrodents.The IPA analysis and confirmatory pharmacodynamics experiments revealed that the main pharmacological effect of APE was anti‐inflammation, which might be achieved by influencing various targets (e.g., AR, AKT, and BAX) and pathways (IL‐8). In the single‐dose toxicity test, no death or abnormal consequences were observed, and maximum tolerated dose of APE was 10 g/kg. Results from the repeated‐dose toxicity tests did not reveal any obvious toxic effects from the repeated daily intragastric administration of APE at 1 g/kg for 8 weeks.In conclusion, APE at a dose of 1 g/kg did not exert any adverse effects, and administration of APE could be beneficial for the inflammatory diseases’ treatment.Practical ApplicationAndrographis paniculata (Burm.f.) Nees is a plant that exerts clearing and detoxification effects and is widely used around the world, but a comprehensive analysis of its efficacy and safety is needed.
Immunization with a combination of recombinant Brucella abortus proteins induces T helper immune response and confers protection against wild‐type challenge in BALB/c mice
Authors: Li Zhiqiang , Wang Shuli , Wei Shujuan , Yang Guangli , Zhang Chunmei , Xi Li , Zhang Jinliang , Cui Yanyan , Hao Junfang , Zhang Huan , Zhang Hui 
Published: February 2022

SummaryProtective efficiency of a combination of four recombinant Brucella abortus (B. abortus) proteins, namely, ribosomal protein L7/L12, outer membrane protein (OMP) 22, OMP25 and OMP31, was evaluated as a combined subunit vaccine (CSV) against B. abortus infection in RAW 264.7 cell line and murine model. Four proteins were cloned, expressed and purified, and their immunocompetence was analysed. BALB/c mice were immunized subcutaneously with single subunit vaccines (SSVs) or CSV. Cellular and humoral immune responses were determined by ELISA. Results of immunoreactivity showed that these four recombinant proteins reacted with Brucella‐positive serum individually but not with Brucella‐negative serum. A massive production of IFN‐γ and IL‐2 but low degree of IL‐10 was observed in mice immunized with SSVs or CSV. In addition, the titres of IgG2a were heightened compared with IgG1 in SSV‐ or CSV‐immunized mice, which indicated that SSVs and CSV induced a typical T‐helper‐1‐dominated immune response in vivo. Further investigation of the CSV showed a superior protective effect in mice against brucellosis. The protection level induced by CSV was significantly higher than that induced by SSVs, which was not significantly different compared with a group immunized with RB51. Collectively, these antigens of Brucella could be potential candidates to develop subunit vaccines, and the CSV used in this study could be a potential candidate therapy for the prevention of brucellosis.
Assessment of the iliocapsularis muscle on magnetic resonance imaging
Authors: Baker Kael S , Vesey Renuka M , Clark Barnaby , Billington Karen , Woodward Rebecca M 
Published: February 2022

AbstractIntroductionMorphologic features of Iliocapsularis (IC) may aid clinical decision‐making in the symptomatic hip. The relationship between IC muscle size and underlying hip pathology is emerging; however, research is limited in the imaging literature. The purpose of this study was to determine the reliability and reproducibility of measurements of the IC muscle and its MRI appearances. It also looked for any association between IC dimension and axial levels, side, gender and bony features of hip instability.MethodsRetrospective study of 37 MRI scans were assessed by four observers. MRI axial T1 images were used to define the IC anatomy, measure the IC and rectus femoris at the femoral head centre (FHC) and adjacent levels and calculate the iliocapsularis‐to‐rectus femoris (IR) ratio. Measurements were repeated at least 2 weeks later. Radiographic assessment of the lateral centre edge angle, acetabular index and femoral neck‐shaft angle were also conducted.ResultsThe IC was always present, but was well‐defined in only 4% of cases with fair agreement. The intraclass correlation coefficient for reliability and reproducibility was the highest for IC width 0.94 (0.91–0.96). No significant correlation was identified between the IR ratio and radiographic parameters.ConclusionIliocapsularis is visible and reliably measured on MRI despite observers considering the muscle to be not well‐defined. Despite gender differences in muscle size, the IR ratio was unchanged. There is a significant difference in the IR ratio above and below the FHC; therefore, clinicians need to be aware of how this may impact the clinical use when utilising the IR ratio.
Cisplatin resistance and malignant behaviors of lung cancer cells are promoted by circ_0002360 via targeting miR‐6751‐3p to regulate the expression of ZNF300
Authors: Ding Lingyan , Li Lizhi , Tang Zhaohui 
Published: February 2022

AbstractBackgroundCircular RNAs (circRNAs) are key regulators in oncogenesis and chemoresistance of human cancers. Herein, we focused on the roles of circ_0002360 in regulating lung cancer progression and cisplatin (DDP) resistance.MethodsThe detection of circ_0002360, microRNA‐6751‐3p (miR‐6751‐3p) and zinc finger protein 300 (ZNF300) was conducted via reverse transcription‐quantitative polymerase chain reaction assay. Cell sensitivity was determined using cell counting kit‐8 assay. Proliferation detection was performed by colony formation assay and EdU assay. The migrated cells were examined via transwell assay. Cell apoptosis analysis was carried out through flow cytometry and caspase 3 activity assay. Western blot was used to examine the protein levels. Target interaction was confirmed through dual‐luciferase reporter assay and RNA immunoprecipitation assay. Circ_0002360 function in vivo was performed via xenograft tumor assay.ResultsCirc_0002360 was overexpressed in DDP‐resistant lung cancer tissues and cells. Silencing circ_0002360 inhibited DDP resistance, proliferation and migration but enhanced apoptosis of DDP‐resistant cells. Circ_0002360 could elevate ZNF300 expression. DDP resistance and lung cancer progression were also impeded by ZNF300 downregulation. ZNF300 overexpression reversed the function of circ_0002360 knockdown in DDP‐resistant lung cancer cells. The regulation of circ_0002360 for ZNF300 was achieved by sponging miR‐6751‐3p. Circ_0002360 promoted DDP resistance in xenograft mice through mediating the miR‐6751‐3p/ZNF300 axis.ConclusionCirc_0002360 targeted miR‐6751‐3p to regulate ZNF300 level, thus elevating DDP resistance and promoting the malignant progression of lung cancer cells.
Microwave ablation via a flexible catheter for the treatment of nonsurgical peripheral lung cancer: A pilot study
Authors: Xie Fangfang , Chen Junxiang , Jiang Yifeng , Sun Jiayuan , Hogarth D. Kyle , Herth Felix J. F. 
Published: February 2022

AbstractBackgroundEndobronchial microwave ablation via flexible catheter offers the potential for local therapy for inoperable peripheral lung cancer. The study aimed to evaluate the feasibility and safety of navigation bronchoscopy‐guided water‐cooled microwave ablation catheter for nonsurgical peripheral lung cancer.MethodsThis was a prospective single arm pilot study. Patients with early stage or multiple primary peripheral lung cancer who were nonsurgical candidates for surgery were enrolled in the study. Bronchoscopic microwave ablation was performed via a flexible water‐cooled microwave ablation antenna under the guidance of navigation bronchoscopy. Radial probe endobronchial ultrasound combined with fluoroscopy was used to confirm the position. Treatment outcomes were evaluated based on follow‐up chest CT and positron emission tomography scans. Primary endpoints were technical success and safety. Secondary endpoints were complete ablation rate, 2‐year local control rate, and progression‐free survival.ResultsThirteen patients were enrolled in the study from April 2018 to July 2019. A total of 19 sessions of microwave ablation were performed on 14 tumors under the guidance of navigation bronchoscopy. The technical success was 100%. Treatment‐related complications occurred in two patients. The complete ablation rate was 78.6% (11/14). The 2‐year local control rate was 71.4%. Median progression‐free survival was 33 months for all patients.ConclusionsIn this pilot study, bronchoscopic microwave ablation appears to be feasible with acceptable occurrence of complication in the treatment of peripheral lung cancer under the guidance of navigation bronchoscopy.
Hematopoietic progenitor cell liabilities and alarmins S100A8/A9‐related inflammaging associate with frailty and predict poor cardiovascular outcomes in older adults
Authors: Bonora Benedetta Maria , Palano Maria Teresa , Testa Gianluca , Fadini Gian Paolo , Sangalli Elena , Madotto Fabiana , Persico Giuseppe , Casciaro Francesca , Vono Rosa , Colpani Ornella , Scavello Francesco , Cappellari Roberta , Abete Pasquale , Orlando Patrizia , Carnelli Franco , Berardi Andrea Giovanni , De Servi Stefano , Raucci Angela , Giorgio Marco , Madeddu Paolo , Spinetti Gaia 
Published: February 2022

AbstractFrailty affects the physical, cognitive, and social domains exposing older adults to an increased risk of cardiovascular disease and death. The mechanisms linking frailty and cardiovascular outcomes are mostly unknown. Here, we studied the association of abundance (flow cytometry) and gene expression profile (RNAseq) of stem/progenitor cells (HSPCs) and molecular markers of inflammaging (ELISA) with the cardiorespiratory phenotype and prospective adverse events of individuals classified according to levels of frailty. Two cohorts of older adults were enrolled in the study. In a cohort of pre‐frail 35 individuals (average age: 75 years), a physical frailty score above the median identified subjects with initial alterations in cardiorespiratory function. RNA sequencing revealed S100A8/A9 upregulation in HSPCs from the bone marrow (>10‐fold) and peripheral blood (>200‐fold) of individuals with greater physical frailty. Moreover higher frailty was associated with increased alarmins S100A8/A9 and inflammatory cytokines in peripheral blood. We then studied a cohort of 104 more frail individuals (average age: 81 years) with multidomain health deficits. Reduced levels of circulating HSPCs and increased S100A8/A9 concentrations were independently associated with the frailty index. Remarkably, low HSPCs and high S100A8/A9 simultaneously predicted major adverse cardiovascular events at 1‐year follow‐up after adjustment for age and frailty index. In conclusion, inflammaging characterized by alarmin and pro‐inflammatory cytokines in pre‐frail individuals is mirrored by the pauperization of HSPCs in frail older people with comorbidities. S100A8/A9 is upregulated within HSPCs, identifying a phenotype that associates with poor cardiovascular outcomes.
Loss of heterochromatin and retrotransposon silencing as determinants in oocyte aging
Authors: Wasserzug‐Pash Peera , Rothman Rachel , Reich Eli , Zecharyahu Lital , Schonberger Oshrat , Weiss Yifat , Srebnik Naama , Cohen‐Hadad Yaara , Weintraub Amir , Ben‐Ami Ido , Holzer Hananel , Klutstein Michael 
Published: February 2022

AbstractMammalian oocyte quality reduces with age. We show that prior to the occurrence of significant aneuploidy (9M in mouse), heterochromatin histone marks are lost, and oocyte maturation is impaired. This loss occurs in both constitutive and facultative heterochromatin marks but not in euchromatic active marks. We show that heterochromatin loss with age also occurs in human prophase I‐arrested oocytes. Moreover, heterochromatin loss is accompanied in mouse oocytes by an increase in RNA processing and associated with an elevation in L1 and IAP retrotransposon expression and in DNA damage and DNA repair proteins nuclear localization. Artificial inhibition of the heterochromatin machinery in young oocytes causes an elevation in retrotransposon expression and oocyte maturation defects. Inhibiting retrotransposon reverse‐transcriptase through azidothymidine (AZT) treatment in older oocytes partially rescues their maturation defects and activity of the DNA repair machinery. Moreover, activating the heterochromatin machinery via treatment with the SIRT1 activating molecule SRT‐1720, or overexpression of Sirt1 or Ezh2 via plasmid electroporation into older oocytes causes an upregulation in constitutive heterochromatin, downregulation of retrotransposon expression, and elevated maturation rates. Collectively, our work demonstrates a significant process in oocyte aging, characterized by the loss of heterochromatin‐associated chromatin marks and activation of specific retrotransposons, which cause DNA damage and impair oocyte maturation.
Major adverse cardiac event rates in moderate‐risk patients: Does prior coronary disease matter?
Authors: McGinnis Henderson D. , Ashburn Nicklaus P. , Paradee Brennan E. , O'Neill James C. , Snavely Anna C. , Stopyra Jason P. , Mahler Simon A. 
Published: February 2022

AbstractBackgroundDespite negative troponins and nonischemic electrocardiograms (ECGs), patients at moderate risk for acute coronary syndrome (ACS) are frequently admitted. The objective of this study was to describe the major adverse cardiac event (MACE) rate in moderate‐risk patients and how it differs based on history of coronary artery disease (CAD).MethodsA secondary analysis of the HEART Pathway implementation study was conducted. This prospective interrupted time‐series study accrued adults with possible ACS from three sites (November 2013–January 2016). This analysis excluded low‐risk patients determined by emergency providers' HEART Pathway assessments. Non–low‐risk patients were further classified as high risk, based on elevated troponin measures or ischemic ECG findings or as moderate risk, based on HEAR score ≥ 4, negative troponin measures, and a nonischemic ECG. Moderate‐risk patients were then stratified by the presence or absence of prior CAD (MI, revascularization, or ≥70% coronary stenosis). MACE (death, myocardial infarction, or revascularization) at 30 days was determined from health records, insurance claims, and death index data. MACE rates were compared among groups using a chi‐square test and likelihood ratios (LRs) were calculated.ResultsAmong 4,550 patients with HEART Pathway assessments, 24.8% (1,130/4,550) were high risk and 37.7% (1715/4550) were moderate risk. MACE at 30 days occurred in 3.1% (53/1,715; 95% confidence interval [CI] = 2.3% to 4.0%) of moderate‐risk patients. Among moderate‐risk patients, MACE occurred in 7.1% (36/508, 95% CI = 5.1% to 9.8%) of patients with known CAD versus 1.4% (17/1,207, 95% CI = 0.9% to 2.3%) in patients without known prior CAD (p < 0.0001). The negative LR for 30‐day MACE among moderate‐risk patients without prior CAD was 0.08 (95% CI = 0.05 to 0.12).ConclusionMACE rates at 30 days were low among moderate‐risk patients but were significantly higher among those with prior CAD.
Fertility preservation in gynaecology oncology patients: Experience from an Australian tertiary oncology centre
Authors: Robson Danielle , de Vries Bradley , Pather Selvan , Marren Anthony 
Published: February 2022

BackgroundManagement for gynaecological cancers often includes removal of the reproductive organs and/or the use of gonadotoxic therapies resulting in sub‐fertility. Oncofertility and discussion of fertility preservation in these patients is critical.AimTo determine the rate of fertility preservation discussion among a cohort of patients with a gynaecological cancer and what determinants impact likelihood of a discussion.Materials and MethodsA seven‐year quantitative retrospective study was conducted at a single oncology centre, including 15–45 year old patients with a gynaecological cancer. The primary outcome was if a fertility preservation discussion occurred during a consultation. Secondary outcomes included if a referral was made and what fertility preservation services were undertaken. Determinants that impacted the likelihood of a fertility preservation discussion were analysed.ResultsOne hundred and twenty‐one patients were analysed. There were 84 (69%) patients who had a documented fertility preservation discussion, and 46% were referred to a fertility specialist for consultation. Age was a significant determinant, with patients aged 30–39 years of age more commonly having a fertility preservation discussion. Patients with a high‐grade cancer compared to patients with a lower‐grade cancer (grade one or two) were only a third as likely to have a discussion surrounding their fertility (odds ratio: 0.33, 95% CI: 0.13–0.86; P = 0.02).ConclusionWe conclude that rates of discussion around fertility options for patients with cancer are lower than the recommended guidelines. Oncofertility is an important discipline which we believe needs to be emphasised within the gynaecology oncology community and management of patients should include a multi‐disciplinary team.