bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategies and tools to aid the transition between paediatric and adult health services for young adults with neurodevelopmental disorders: a scoping review protocol
Authors: Thanalingam Yattheesh , Langridge Fiona , Gordon Iris , Russell Jin , Muir Colette , Hamm Lisa Marie 
Published: November 2022

IntroductionThe transition from paediatric to adult healthcare comes with risk and vulnerability for young adults with neurodevelopmental disorders and their carers. Deficits in health, social and disability systems and the fragmentation of services exacerbate problems during the transition period, leaving young people and their carers feeling disconnected with existing services. With advances in healthcare, the number of young adults with neurodevelopmental disorders requiring transition services is increasing. This scoping review aims to summarise the strategies and tools that help ease the transition to adult services for young adults with neurodevelopmental disorders.Methods and analysisSystematic searches of MEDLINE, EMBASE and PsychInfo on the OVID platform were performed on 28/05/2022. Studies that describe tools or strategies designed to ease the transition from child-centred to adult-orientated healthcare for young adults with neurodevelopmental disorders will be included. Two authors will independently review titles, abstracts and full-text articles against the inclusion criteria to determine eligibility. Data will be extracted and synthesised using descriptive stats and thematic analysis. The Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews guidelines will be followed.ConclusionThis scoping review will synthesise the published literature describing strategies and tools to improve the transition of young adults with neurodevelopmental disorders to adult services. The findings of the review may inform areas of future research to improve care for all involved in the transition process.Ethics and disseminationThis review will include published data; as such, ethics approval is not required. We will publish our findings in an open-access, peer-reviewed journal and summarise the results for dissemination to the wider community of clinicians, allied healthcare professionals, teaching professionals, policymakers, non-governmental organisations, impacted youth and parents.
Study protocol for Video Images about Decisions to Improve Ethical Outcomes with Palliative Care Educators (VIDEO-PCE): a pragmatic stepped wedge cluster randomised trial of older patients admitted to the hospital
Authors: Lakin Joshua R , Zupanc Sophia N , Lindvall Charlotta , Moseley Edward T , Das Sophiya , Sciacca Kate , Cabral Howard J , Burns Edith A , Carney Maria T , Itty Jennifer , Lopez Santiago , Emmert Kaitlin , Martin Narda J , Lambert Sherene , Polo Jennifer , Sanghani Shreya , Dugas Julianne N , Gomez Michele , Winter Michael R , Wang Na , Gabry-Kalikow Shira , Dobie Alexandra , Amshoff Meredith , Cucinotta Traci , Joel Milton , Caruso Lisa B , Ramirez Ana Maria , Salerno Kathleen , Ogunneye Qausarat , Henault Lori , Davis Aretha Delight , Volandes Angelo , Paasche-Orlow Michael K 
Published: November 2022

Introduction
Despite the known benefit to patients and families, discussions about goals, values and preferences for medical care in advancing serious illness often do not occur. Many system and clinician factors, such as patient and clinician reticence and shortage of specialty palliative care teams, contribute to this lack of communication. To address this gap, we designed an intervention to promote goals-of-care conversations and palliative care referrals in the hospital setting by using trained palliative care educators and video decision aids. This paper presents the rationale, design and methods for a trial aimed at addressing barriers to goals-of-care conversations for hospitalised adults aged 65 and older and those with Alzheimer’s disease and related Dementias, regardless of age.

Methods and analysis
The Video Image about Decisions to Improve Ethical Outcomes with Palliative Care Educators is a pragmatic stepped wedge, cluster randomised controlled trial, which aims to improve and extend goals-of-care conversations in the hospital setting with palliative care educators trained in serious illness communication and video decision aids. The primary outcome is the proportion of patients with goals-of-care documentation in the electronic health record. We estimate that over 9000 patients will be included.

Ethics and dissemination
The Institutional Review Board (IRB) at Boston Medical Center will serve as the single IRB of record for all regulatory and ethical aspects of this trial. BMC Protocol Number: H-41482. Findings will be presented at national meetings and in publications. This trial is registered at ClinicalTrials.gov.

Trial registration number

NCT04857060
; ClinicalTrials.gov
Pain predict genetics: protocol for a prospective observational study of clinical and genetic factors to predict the development of postoperative pain
Authors: Li Song , van Boekel Regina L M , van den Heuvel Sandra A S , Coenen Marieke J H , Vissers Kris C P 
Published: November 2022

IntroductionPostoperative pain remains a challenging medical condition impacting the quality of life of every patient. Although several predictive factors for postoperative pain have been identified, an adequate prediction of postoperative pain in patients at risk has not been achieved yet.The primary objective of this study is to identify specific genetic risk factors for the development of acute and chronic postoperative pain to construct a prediction model facilitating a more personalised postoperative pain management for each individual. The secondary objectives are to build a databank enabling researchers to identify other risk factors for postoperative pain, for instance, demographic and clinical outcome indicators; provide insight into (genetic) factors that predict pharmacological pain relief; investigate the relationship between acute and chronic postoperative pain.Methods and analysisIn this prospective, observational study, patients who undergo elective surgery will be recruited to a sample size of approximately 10 000 patients. Postoperative acute and chronic pain outcomes will be collected through questionnaires at different time points after surgery in the follow-up of 6 months. Potential genetic, demographic and clinical risk factors for prediction model construction will be collected through blood, questionnaires and electronic health records, respectively.Genetic factors associated with acute and/or chronic postoperative pain will be identified using a genome-wide association analysis. Clinical risk factors as stated in the secondary objectives will be assessed by multivariable regression. A clinical easy-to-use prediction model will be created for postoperative pain to allow clinical use for the stratification of patients.Ethics and disseminationThe Institutional Review Board of the Radboud university medical centre approved the study (authorisation number: 2012/117). The results of this study will be made available through peer-reviewed scientific journals and presentations at relevant conferences, which will finally contribute to personalised postoperative pain management.Trial registration numberNCT02383342.
Protocol for a collaborative randomised effectiveness trial of lay-delivered versus clinician-delivered behavioural activation in senior centres
Authors: Raue Patrick J , Sirey Jo Anne , Gum Amber , Hawrilenko Matt , Fisher Dylan M 
Published: November 2022

IntroductionDepression is common among community-dwelling older adults who make use of senior centre services yet remains undertreated due to a lack of acceptable and available treatments. Emerging evidence suggests that lay health providers can offer psychosocial interventions for mental health disorders experienced by older adults. We developed a streamlined Behavioural Activation intervention (called ‘Do More, Feel Better’; DMFB) to be delivered by older adult volunteers and propose to compare its effectiveness to that of clinician-delivered behavioural activation (BA).Methods and analysisThis study is a type I collaborative randomised effectiveness trial testing the effect of DMFB in comparison to BA among 288 senior centre clients (aged 60+). Participant clients will be recruited from 6 Seattle, 6 New York City and 6 Tampa area senior centres serving economically and ethnically diverse communities. Primary outcomes will be increased activity level (target) and decreased depressive symptoms. Secondary outcomes will be functioning and client satisfaction, and an exploratory outcome will be treatment fidelity.Ethics and disseminationThe study received ethics approval from the University of Washington Institutional Review Board (STUDY00011434). Client, volunteer and clinician participants will all provide informed consent for study procedures through in-person or remote contact with investigators. Results of this study will be presented in peer-reviewed journals and at professional conferences.Trial registration numberNCT04621877; ClinicalTrials.gov.
Prevalence and risk factors of work-related contact dermatitis symptoms among healthcare cleaners during the COVID-19 pandemic in Northwest Ethiopia: a multicentre cross-sectional survey
Authors: Tesfaye Amensisa Hailu , Engdaw Garedew Tadege , Aragaw Fantu Mamo , Kabito Gebisa Guyasa 
Published: November 2022

ObjectiveThis study was aimed to explore the prevalence and risk factors of work-related contact dermatitis (WRCD) symptoms among cleaners working in healthcare institutions in Gondar city, Northwest Ethiopia, during the COVID-19 pandemic.DesignA multicentre cross-sectional study was conducted from September to October 2021. An interviewer-administered standardised Nordic Occupational Skin Questionnaire, V.2002 (NOSQ-2002) was used to assess WRCD. The collected data were entered into EpiData V.4.6 and analysed using Stata V.14 software. The association between dependent and independent variables was computed with a binary logistic regression. The association was determined using an adjusted OR (AOR) with a 95% CI at a p value of <0.05.SettingThe study was conducted in Gondar city healthcare institutions, Northwestern Ethiopia.ParticipantsA total of 409 cleaners participated in this study.Outcome measuresThe primary outcome is the prevalence of WRCD symptoms, which was measured using the NOSQ-2002.ResultsThe response rate was 95.6%. The majority, 302 (73.8%), of the study participants were female. The mean age (±SD) was 31 (±7.87) years old. The overall prevalence of self-reported WRCD during the last 12 months was 213 (52.1%) (95% CI (47.1% to 57.0%)). The highest symptoms reported were skin redness, 51.6% (n=110), and the most affected skin body sites were hands (hand dermatitis), 74.2% (n=158). Hand washing frequency more than 20 times per day (AOR=1.73, 95% CI (1.03 to 2.92)), personal history of eczema (AOR=1.46, 95% CI (1.01 to 2.42)) and lack of training on skin hazards (AOR=2.06, 95% CI (1.16 to 3.63)) were factors influencing the occurrence of WRCD.ConclusionsThis study revealed the prevalence of WRCD is common during the COVID-19 pandemic. Adjusting hand washing frequency per day, educating people with atopy about the avoidance of exposure to skin irritants and providing training on skin hazards were recommended to minimise the condition.
The Fusion-by-Diffusion model as a tool to calculate cross sections for the production of superheavy nuclei
Authors: Cap T. , Kowal M. , Siwek-Wilczyńska K. 
Published: November 2022

AbstractThis article summarizes recent progress in our understanding of the reaction mechanisms leading to the formation of superheavy nuclei in cold and hot fusion reactions. Calculations are done within the Fusion-by-Diffusion (FBD) model using the new nuclear data tables by Jachimowicz et al. (At Data Nucl Data Tables 138, 101393, 2021). The synthesis reaction is treated in a standard way as a three-step process (i.e., capture, fusion, and survival). Each reaction step is analysed separately. Model calculations are compared with selected experimental data on capture, fissionlike and fusion cross sections, fusion probabilities, and evaporation residue excitation functions. The role of the angular momentum in the fusion step is discussed in detail. A set of fusion excitation functions with corresponding fusion probabilities is provided for cold and hot synthesis reactions.
Population transfer under local dephasing
Authors: Huang Wei , Zhang Wentao , Du Xinwei , Guo Chu 
Published: November 2022

AbstractStimulated Raman adiabatic passage is a well-known technique for quantum population transfer due to its robustness again various sources of noises. Here we consider quantum population transfer from one spin to another via an intermediate spin which is under dephasing noise. We obtain an analytic expression for the transfer efficiency under a specific driving protocol, showing that dephasing could reduce the transfer efficiency, but the effect of dephasing could also be suppressed with a stronger laser coupling or a longer laser duration. We also consider another commonly used driving protocol, which shows that this analytic picture is still qualitatively correct.
Quantum algorithm for calculating risk contributions in a credit portfolio
Authors: Miyamoto Koichi 
Published: November 2022

AbstractFinance is one of the promising field for industrial application of quantum computing. In particular, quantum algorithms for calculation of risk measures such as the value at risk and the conditional value at risk of a credit portfolio have been proposed. In this paper, we focus on another problem in credit risk management, calculation of risk contributions, which quantify the concentration of the risk on subgroups in the portfolio. Based on the recent quantum algorithm for simultaneous estimation of multiple expected values, we propose the method for credit risk contribution calculation. We also evaluate the query complexity of the proposed method and see that it scales as$\widetilde{O} (\sqrt{N_{\mathrm{gr}}}/\epsilon )$O˜(Ngr/ϵ)on the subgroup number$N_{\mathrm{gr}}$Ngrand the accuracyϵ, in contrast with the classical method with$\widetilde{O} (\log(N_{\mathrm{gr}})/\epsilon^{2} )$O˜(log(Ngr)/ϵ2)complexity. This means that, for calculation of risk contributions of finely divided subgroups, the advantage of the quantum method is reduced compared with risk measure calculation for the entire portfolio. Nevertheless, the quantum method can be advantageous in high-accuracy calculation, and in fact yield less complexity than the classical method in some practically plausible setting.
Dexamethasone Coanalgesic Administration in Steroid Naïve and Steroid Non-Naïve Patients for the Prevention of Pain Flares after Palliative Radiotherapy for Bone Metastases
Authors: Tonev Dimitar G. , Lalova Silvia A. , Petkova-Lungova Elena P. , Timenov Nikolay V. , Radeva Gabriela M. , Kundurzhiev Todor G. 
Published: November 2022

Objective. Dexamethasone could be an effective prophylactic agent for the prevention of pain flares after palliative radiotherapy (RT) for uncomplicated bone metastases. To date, there are no data on its prophylactic coanalgesic (opioid-sparing) effect after RT in patients with complicated bone metastases compared to uncomplicated ones, which is the aim of our study. Methods. Twenty-nine American Society of Anaesthesiologists (ASA) III-IV patients, aged ≥18, treated with single-fraction 8 Gy/1 or multi-fraction 20 Gy/5 RT for painful uncomplicated bone metastases (steroid naïve patients, n = 14) or complicated ones (steroid non-naïve patients, n = 15), were examined retrospectively. All patients received parenteral dexamethasone (4 mg or 8 mg daily, 1 hour before RT, followed by the same dose for the next 4 days) along with their background and breakthrough pain opioid intake (morphine equivalents) during their 5-day in-hospital stay. Pain severity (numeric rating scale) and analgesic consumption were recorded at admission, daily during the hospital stay, and for 10 days following treatment. Binary logistic regression was used to determine predictive factors for pain flare occurrence. Results. A higher ASA score is the only determinant positively influencing opioid consumption (

P

= 0.018) and pain flare as well (OR = 15.00; 95% CI: 2, 24–100, 48;

P

= 0.005). Lower dose 4 mg dexamethasone was revealed as a moderate analgesic agent in steroid naïve patients with no side effects, whereas in steroid non-naïve patients the predominantly higher dose 8 mg dexamethasone had minimal impact on pain flares prevention at the expense of more pronounced immunosuppression (

P

= 0.039). Conclusions. Irrespective of the supporting evidence of dexamethasone potential for prevention of RT-induced pain flare, our data failed to reveal its efficacy in the real practice world (a case mix of uncomplicated and complicated bone metastases). Further dose-effect bigger studies are needed, identifying optimal doses of dexamethasone intake and its optimal duration in high-risk patients.
LZTR1Mutation Mediates Oncogenesis through Stabilization of EGFR and AXL
Authors: Ko Aram , Hasanain Mohammad , Oh Young Taek , D'Angelo Fulvio , Sommer Danika , Frangaj Brulinda , Tran Suzanne , Bielle Franck , Pollo Bianca , Paterra Rosina , Mokhtari Karima , Soni Rajesh Kumar , Peyre Matthieu , Eoli Marica , Papi Laura , Kalamarides Michel , Sanson Marc , Iavarone Antonio , Lasorella Anna 
Published: November 2022

AbstractLZTR1 is the substrate-specific adaptor of a CUL3-dependent ubiquitin ligase frequently mutated in sporadic and syndromic cancer. We combined biochemical and genetic studies to identify LZTR1 substrates and interrogated their tumor-driving function in the context of LZTR1 loss-of-function mutations. Unbiased screens converged on EGFR and AXL receptor tyrosine kinases as LZTR1 interactors targeted for ubiquitin-dependent degradation in the lysosome. Pathogenic cancer-associated mutations of LZTR1 failed to promote EGFR and AXL degradation, resulting in dysregulated growth factor signaling. Conditional inactivation of Lztr1 and Cdkn2a in the mouse nervous system caused tumors in the peripheral nervous system including schwannoma-like tumors, thus recapitulating aspects of schwannomatosis, the prototype tumor predisposition syndrome sustained by LZTR1 germline mutations. Lztr1– and Cdkn2a-deleted tumors aberrantly accumulated EGFR and AXL and exhibited specific vulnerability to EGFR and AXL coinhibition. These findings explain tumorigenesis by LZTR1 inactivation and offer therapeutic opportunities to patients with LZTR1-mutant cancer.Significance:EGFR and AXL are substrates of LZTR1-CUL3 ubiquitin ligase. The frequent somatic and germline mutations of LZTR1 in human cancer cause EGFR and AXL accumulation and deregulated signaling. LZTR1-mutant tumors show vulnerability to concurrent inhibition of EGFR and AXL, thus providing precision targeting to patients affected by LZTR1-mutant cancer.This article is highlighted in the In This Issue feature, p. 517
Effects of Carotid Artery Stiffness on Cerebral Small‐Vessel Disease and Cognition
Authors: Robert Caroline , Ling Lieng‐Hsi , Tan Eugene S. J. , Gyanwali Bibek , Venketasubramanian Narayanaswamy , Lim Shir Lynn , Gong Lingli , Berboso Josephine Lunaria , Richards Arthur Mark , Chen Christopher , Hilal Saima 
Published: November 2022

Background
Carotid artery stiffness is associated with cognitive impairment and dementia, but the underlying mechanisms remain unknown. We examined the associations of carotid artery stiffness with cerebral small‐vessel disease markers, cognition, and dementia subtypes in a memory clinic cohort.

Methods and Results

A total of 272 participants underwent carotid ultrasonography, 3 Tesla brain magnetic resonance imaging, and neuropsychological assessment. Carotid ultrasonography was used to assess β‐index, pressure‐strain elastic modulus, and pulse‐wave velocity‐β. Brain magnetic resonance images were graded for cerebral small‐vessel disease markers, including white matter hyperintensities, lacunes, and cerebral microbleeds. Participants were classified as having no cognitive impairment, cognitive impairment and no dementia, or dementia subtyped as Alzheimer disease and vascular dementia. Cognition was assessed using National Institute of Neurological Disorders and Stroke–Canadian Stroke Network harmonization battery. After adjusting for age, sex, cardiovascular risk factors, and diseases, multivariable models showed that β‐index (
β
=0.69;
P
=0.002), elastic modulus (
β
=0.78;
P
<0.001), and pulse‐wave velocity‐β (
β
=0.80;
P
<0.001) were associated with white matter hyperintensities, and elastic modulus (odds ratio [OR], 1.39 [95% CI, 1.04–1.85]) and pulse‐wave velocity‐β (OR, 1.47 [95% CI, 1.10–1.98]) were independently associated with lacunes. Similarly, β‐index (OR, 2.04 [95% CI, 1.14–4.13]), elastic modulus (OR, 2.22 [95% CI, 1.25–4.42]), and pulse‐wave velocity‐β (OR, 2.50 [95% CI, 1.36–5.18]) were independently associated with vascular dementia. Carotid stiffness measures were independently associated with worse performance in global cognition, visuomotor speed, visuospatial function, and executive function. These associations became largely nonsignificant after further adjusting for cerebral small‐vessel disease markers.

Conclusions
In memory clinic patients, carotid artery stiffness was associated with white matter hyperintensities and lacunes, impairment in global and domain‐specific cognition, and causative subtypes of dementia, particularly vascular. The effects of carotid stiffness on cognition were not independent of, and were partially mediated by, cerebral small‐vessel disease.