bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spread the word: Certifying sustainable behaviour for territorial development. A stakeholder engagement approach to assess financial performance
Authors: Manta Francesco , Stefanelli Valeria , Boscia Vittorio 
Published: October 2022

AbstractThe aim of the study is to understand the approach to certification from different perspectives, in order to appreciate how the stakeholders, enact processes of creation, implementation and decision‐making processes in establishing criteria for local development. We analysed the extant literature in order to assess the present knowledge and approach on the world of labelling for sustainable development and detect possible paths for future research in the field. A document search was conducted through Scopus and WoS databases. Sustainable certifications do not cover a univocal path of implementation, so it is made necessary to establish a network approach in order to involve all the stakeholders to boost new processes for implementation of bottom‐up strategies for sustainable development. The necessity to start a new approach to local development strategies recalls the opportunity of creating new local networks amongst different stakeholders to talk each other on a univocal perspective that looks with favour to sustainability issues and enhance the link to financial performance. The example of bio‐districts is carried on enforcing the theoretical aspects.
Autonomic nervous system reactivity and preschoolers’ social dominance
Authors: Lent Maria C. , Perry Kristin J. , Blakely‐McClure Sarah J. , Buck Casey , Murray‐Close Dianna , Ostrov Jamie M. 
Published: October 2022

AbstractThe purpose of this study was to investigate the role of skin conductance level reactivity (SCLR) and respiratory sinus arrhythmia reactivity (RSAR) in preschoolers’ social dominance, as well as potential gender differences in these associations. Reactivity was assessed in response to viewing videos of social exclusion and a post‐aggression discussion. In a community sample of 94 preschool children followed over one calendar year, reactivity to the post‐aggression discussion, but not exclusion, video was related to social dominance. Specifically, increased RSAR to the post‐aggression discussion video was positively associated with concurrent social dominance for both boys and girls. Longitudinally, for boys only, coactivation (i.e., increases in SCLR accompanied by increases in RSAR) to the post‐aggression discussion video, which may reflect dysregulated, emotionally labile reactions to stress, was associated with relatively low levels of social dominance across the course of the year. Overall, findings contribute to a growing literature documenting the role of autonomic reactivity in preschoolers’ social adjustment and extend this work to their capacity to achieve and maintain socially dominant positions with peers.
Medical treatment in infants and young children with epilepsy: Off‐label use of antiseizure medications. Survey Report of ILAE Task Force Medical Therapies in Children
Authors: Sourbron Jo , Auvin Stéphane , Arzimanoglou Alexis , Cross J. Helen , Hartmann Hans , Pressler Ronit , Riney Kate , Sugai Kenji , Wilmshurst Jo M. , Yozawitz Elissa , Lagae Lieven 
Published: October 2022

AbstractObjectiveAntiseizure medications (ASMs) remain the mainstay of epilepsy treatment. These ASMs have mainly been tested in trials in adults with epilepsy, which subsequently led to market authorization (MA). For treatment of – especially young – children with epilepsy, several ASMs do not have a MA and guidelines are lacking, subsequently leading to “off‐label” use of ASMs. Even though “off‐label” ASM prescriptions for children could lead to more adverse events, it can be clinically appropriate and rational if the benefits outweigh the risks. This could be the case if “on‐label” ASM, in mono‐ or polytherapy, fails to achieve adequate seizure control.MethodsThe Medical Therapies Task Force of the International League Against Epilepsy (ILAE) Commission for Pediatrics performed a survey to study the current treatment practices in six classic, early life epilepsy scenarios. Our aim was not only to study first‐ and second‐line treatment preferences but also to illustrate the use of “off‐label” drugs in childhood epilepsies.ResultsOur results reveal that several ASMs (e.g. topiramate, oxcarbazepine, benzodiazepines) are prescribed “off‐label” in distinct scenarios of young children with epilepsy. In addition, recent scientific guidelines were not always adopted by several survey respondents, suggesting a potential knowledge gap.SignificanceWe report the relatively common use of “off‐label” prescriptions that underlines the need for targeted and appropriately designed clinical trials, including younger patients, which will also result in the ability to generate evidence‐based guidelines.
Clinical correlates of late‐onset versus early‐onset bipolar disorder in a global sample of older adults
Authors: Lavin Paola , Buck Gabriella , Almeida Osvaldo P. , Su Chien‐Lin , Eyler Lisa T. , Dols Annemieke , Blumberg Hilary P. , Forester Brent P. , Forlenza Orestes V. , Gildengers Ariel , Mulsant Benoit H. , Tsai Shang‐Ying , Vieta Eduard , Schouws Sigfried , Briggs Farren B. S. , Sutherland Ashley , Sarna Kaylee , Yala Joy , Orhan Melis , Korten Nicole , Sajatovic Martha , Rej Soham ,   GAGE‐BD Investigators
Published: October 2022

AbstractObjectivesLate‐onset bipolar disorder (LOBD) represents a significant subgroup of bipolar disorder (BD). However, knowledge for this group is mostly extrapolated from small studies in subjects with early/mixed age of illness onset. In this global sample of older adults with BD (OABD: ≥50 years old) we aim to characterize the sociodemographic and clinical presentation of LOBD (≥40 years at BD onset) compared to early‐onset BD (EOBD: <40 years at BD onset).MethodsThe Global Aging and Geriatric Experiments in Bipolar Disorder consortium provided international data on 437 older age bipolar disorder participants. We compared LOBD versus EOBD on depression, mania, functionality, and physical comorbidities. Exploratory analyses were performed on participants with BD onset ≥50 years old.ResultsLOBD (n = 105) did not differ from EOBD (n = 332) on depression, mania, global functioning, nor employment status (p > 0.05). Late‐onset bipolar disorder was associated with higher endocrine comorbidities (odds ratio = 1.48, [95%CI = 1.0,12.1], p = 0.03). This difference did not remain significant when subjects with BD onset ≥50 years old were analyzed.LimitationsThis study is limited by the retrospective nature of the variable age of onset and the differences in evaluation methods across studies (partially overcame by harmonization processes).ConclusionThe present analysis is in favor of the hypothesis that LOBD might represent a similar clinical phenotype as classic EOBD with respect to core BD symptomatology, functionality, and comorbid physical conditions. Large‐scale global collaboration to improve our understanding of BD across the lifespan is needed.
Outcomes of subjects who are lean, overweight or obese with nonalcoholic fatty liver disease: A cohort study in China
Authors: Lan Yanqi , Lu Ying , Li Jinfeng , Hu Shiqi , Chen Shuohua , Wang Yanhong , Yuan Xiaojie , Liu Hongmin , Wang Xiaomo , Wu Shouling , Wang Li 
Published: October 2022

Abstract
The ability to determine the prognosis of lean nonalcoholic fatty liver disease (NAFLD) is essential for decision making in clinical settings. Using a large community‐based Chinese cohort, we aimed to investigate NAFLD outcomes by body mass index (BMI). We used the restricted cubic splines method to investigate the dose–response relationship between BMI and outcomes in subjects with NAFLD and those without NAFLD. We included 73,907 subjects from the Kailuan cohort and grouped all subjects into four phenotypes by using NAFLD and BMI (<23 kg/m2). The probability of developing outcomes for individuals with lean NAFLD (LN), overweight/obese NAFLD (ON), overweight/obese non‐NAFLD (ONN), and lean non‐NAFLD (LNN) was estimated. We found a U‐shaped association between BMI and death but a linear positive association concerning cardiovascular disease (CVD) after adjusting for age and other covariates. Compared with the LNN group, the adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of the LN, ON, and ONN groups were 1.30 (1.14–1.49), 0.86 (0.80–0.91), 0.84 (0.80–0.89) for all‐cause death, 2.61 (1.13–6.03), 0.74 (0.44–1.26), 1.10 (0.70–1.74) for liver‐related death, 2.12 (1.46–3.08), 1.23 (0.99–1.54), 1.19 (0.98–1.43) for digestive system cancers, and 2.04 (1.40–2.96), 1.30 (1.05–1.61), 1.21 (1.01–1.46) for obesity‐related cancers. Subjects with LN had a significantly higher risk of colorectal cancer and esophagus cancer. However, the ON group had the highest CVD risk (HR, 1.39; 95% CI, 1.27–1.52). The LN group with hypertension had a higher risk of adverse outcomes, and those without hypertension had a similar risk compared to LNN. Conclusion: Subjects with LN may experience a higher risk of all‐cause death, digestive system cancers, and obesity‐related cancers than the other three groups but a lower risk of CVD than ON subjects. LN with hypertension may be a high‐risk phenotype.
Quantifying and comparing the effects of human and organizational factors in electric maloperation accidents with HFACS–CatBoost and SHAP
Authors: Lin Chuan , Xu Qifeng , Huang Yifan 
Published: October 2022

AbstractThe proportion of electric maloperation accidents (EMAs) in substations caused by human and organizational factors (HOFs) has gradually increased. Although there has been some research into the factors affecting EMAs in substations, the available results are insufficient to support the interpretation of HOFs in EMAs. This article explores the relationships between the HOFs and EMAs using Human Factors Analysis and Classification System‐gradient boosting with categorical features support (HFACS–CatBoost) and Shapley Additive exPlanation (SHAP) methods. First, the HFACS framework was introduced to identify 135 EMAs in the Southern Power Grid risk causation. CatBoost was used to construct an accident classification model to analyze the important relationship between accidents and HOFs and to compare and analyze with the extreme gradient boosting (XGBoost) and the binary logistic regression (BLR) to verify the superiority of CatBoost. Finally, to solve the problem of inadequate interpretation of the CatBoost black‐box model, the SHAP value plot was applied to express the contribution degree relationship between accidents and HOFs. The results show that the above method can explore and explain the importance and contribution of HOFs in EMAs. And from this, it is concluded that poor psychological state, poor communication and coordination, inadequate supervision, and inadequate training and education are highly correlated with the occurrence of EMAs. The findings will help substation operations and maintenance staff to develop safety measures to address the confusion of HOFs in substations and prevent the occurrence of EMAs.
Prehospital medicine learning experience for pharmacy residents
Authors: Acquisto Nicole M. , Cushman Jeremy T. , Johnston Melinda , Sensenbach Benjamin 
Published: October 2022

AbstractPharmacist collaboration with medical directors and practitioners operating in the emergency medical services (EMS) system can improve overall care, optimize the medication formulary, and decrease medication‐related risk. However, to achieve this, pharmacists must have a fundamental understanding of the prehospital medicine environment. We describe a comprehensive prehospital medicine postgraduate training experience for postgraduate year two (PGY2) emergency medicine (EM) pharmacy residents. A detailed description of the prehospital medicine learning experience (LE) is provided that includes an immersive schedule with diverse EMS exposure, attendance at dedicated EMS‐specific medical resident conferences, didactic and self‐learning requirements, and a scholarly EMS project. Information regarding how this LE is organized and evaluated, as well as challenges and future directions are provided. Program success is highlighted with the reporting of 20 scholarly projects completed by PGY2 EM pharmacy residents from 2006 through 2022 in collaboration with EMS and the Division of Prehospital Medicine. A collaborative and immersive prehospital medicine LE for PGY2 EM pharmacy residents can be mutually beneficial for the training of the pharmacy resident, scholarly productivity supporting regional and statewide change, and EMS personnel.
Pharmacist involvement in sepsis response and time to antibiotics: A systematic review
Authors: Atkins Payton E. , Thompson Bastin Melissa L. , Morgan Rebecca J. , Laine Melanie E. , Flannery Alexander H. 
Published: October 2022

AbstractIntroductionSepsis is a life‐threatening medical emergency and a leading cause of morbidity and mortality worldwide. Reductions in time to antibiotics in patients presenting with sepsis or septic shock are associated with reduced mortality, and Surviving Sepsis Campaign guidelines recommend antibiotics within 1 h of recognition. Pharmacists are well‐equipped to help navigate the therapeutic and operational challenges associated with achieving this goal.ObjectivesTo assess the association of pharmacist involvement in sepsis response with time to antibiotics in hospitalized patients with sepsis and septic shock.MethodsA systematic review of the following databases was conducted: PubMed/MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science. Studies must have included a designated role of an individual pharmacist in the management of sepsis or septic shock and not be considered an operational change. The primary outcome of interest was time to antibiotic administration, with secondary outcomes including intensive care unit (ICU) and hospital length of stay as well as in‐hospital mortality.ResultsWe identified 10 studies including 1772 patients with sepsis or septic shock that evaluated a sepsis response in which a pharmacist was included. Studies included patients in the ICU, emergency department, and hospital ward setting. Seven studies demonstrated a significant reduction in time to antibiotics, with two other studies supporting this conclusion in extrapolation or sensitivity analysis. There was not a consistent reduction in ICU or hospital length of stay nor in‐hospital mortality between those interventions involving a pharmacist compared with their defined control groups.ConclusionPharmacist involvement in sepsis response, often as part of a multiprofessional team‐based approach to sepsis care, is associated with a reduced time to antibiotic administration for hospitalized patients with sepsis or septic shock.
Morbidity of colectomy during pancreatoduodenectomy: An analysis of the pancreas‐targeted American College of Surgeons National Surgical Quality Improvement Program Registry
Authors: Harris Larkin B. , Osborn Tamara A. , Bennett Judy L. , Jensen Hanna K. , Giorgakis Emmanouil , Mavros Michail N. 
Published: October 2022

AbstractBackgroundPancreatoduodenectomy is a complex operation with considerable morbidity and mortality. Locally advanced tumors may require concurrent colectomy. We hypothesized that a concurrent colectomy increases the risk associated with pancreatoduodenectomy.MethodsThis retrospective review of the 2014–2019 pancreas‐targeted American College of Surgeons National Surgical Quality Improvement Program registry classified operations as pancreatoduodenectomy (PD) versus pancreatoduodenectomy/colectomy (PD+C). The two groups were compared with respect to demographics, comorbidities, disease characteristics, intraoperative variables, and postoperative outcomes. Main effect models were developed to examine the effect of concurrent colectomy on outcomes after adjusting for potential confounders.ResultsOf 24 421 pancreatoduodenectomies, 430 (1.8%) involved concurrent colectomy. PD + C patients had less comorbidities (obesity 19% vs. 27%, hypertension 43% vs. 53%, diabetes 20% vs. 26%) and were associated with malignant diagnosis (94% vs. 83%), vascular resection (28% vs. 18%), and longer operative time (median 6.9 vs. 6 h). On multivariable analysis, concurrent colectomy was independently associated with serious morbidity (adjusted odds ratio [OR] 2.62, 95% confidence interval [CI]: 1.94–3.54) but not mortality (OR 1.44 [0.63–3.31]).ConclusionsConcurrent colectomy at the time of pancreatoduodenectomy significantly increased the odds of serious morbidity but did not affect mortality. This should be considered in operative planning, preoperative counseling, and sequencing of cancer‐directed treatments.
Inhibition of CGRP signaling impairs fracture healing in mice
Authors: Wee Natalie K. Y. , Novak Sanja , Ghosh Debolina , Root Sierra H. , Dickerson Ian M. , Kalajzic Ivo 
Published: October 2022

AbstractCalcitonin gene‐related peptide (CGRP) is a neuropeptide produced by sensory nerves and functions as a pain sensor. It acts by binding to the calcitonin‐like receptor (CLR, protein; Calcrl, gene). CGRP inhibition has been recently introduced as therapeutic treatment of migraine‐associated pain. Previous studies have shown that CGRP stimulates bone formation. The aim of our study is to determine whether the inhibition of CGRP signaling negatively impacted fracture healing. Using α‐smooth muscle actin (αSMA) Cre animals crossed with Ai9 reporter mice, we showed that CGRP‐expressing nerves are near αSMA + cells in the periosteum. In vitro experiments revealed that periosteal cells express Calcrl and receptor activity modifying protein 1; and CGRP stimulation increased periosteal cell proliferation. Using a tamoxifen‐inducible model αSMACre/CLRfl/fl, we targeted the deletion of CLR to periosteal progenitor cells and examined fracture healing. Microcomputed tomography of fractured femurs showed a reduction in bone mass in αSMACre+/CLRfl/fl female mice relative to controls and callus volume in males. Pharmacological CGRP–CLR inhibition was achieved by subcutaneous delivery of customized pellets with small molecule inhibitor olcegepant (BIBN‐4096) at a dose of 10 μg/day. BIBN‐4096‐treated C57BL/6J mice had a higher latency toward thermal nociception than placebo‐treated mice, indicating impaired sensory function through CGRP inhibition. CGRP inhibition also resulted in reduced callus volume, bone mass, and bone strength compared to placebo controls. These results indicate that inhibiting CGRP by deleting CLR or by using BIBN‐4096, contributes to delayed bone healing.
Density functional theory demonstrates orientation effects in the Raman spectra of hydroxy‐ and carbonated apatite
Authors: Gemeri Dejan , Živković Aleksandar , Lukačević Igor , Bahmann Hilke , King Helen E. 
Published: October 2022

AbstractRaman spectroscopy is widely used to examine the carbonate content within bone apatite, but Raman spectra are also sensitive to orientation effects between the polarisation of the incoming laser light and the sample orientation. This may lead to discrepancies when using Raman spectroscopy to evaluate the carbonate content as the extent of crystal organisation can change depending on the type of bone, age, and presence of mineralisation disorders in the organism. It is experimentally very challenging to evaluate the effect of orientation using individual bone crystals. Therefore, we have used density functional theory to examine the effect of orientation in apatitic materials. We examined hydroxyapatite and three different types of carbonated apatite: A‐type where the carbonate ion substitutes the two OH groups in the unit cell, B‐type where co‐substitution occurs between carbonate in a phosphate position and Na+ for Ca2+ to maintain charge balance, and AB‐type where carbonate sits in both A‐site and B‐site. Our simulations show that the OH group in hydroxyapatite has a strong orientation dependence, consistent with previous literature. In addition, the phosphate and carbonate bands of the apatitic structures are predicted to be orientation dependent, where the maximum scattering efficiency occurs in configurations in which the laser polarisation is parallel to the crystallographic axes of the material. The intensity changes of the phosphate and carbonate bands are not consistent upon changing orientations and thus may lead to an underestimation of carbonate contents if insufficient sampling points are used during bone analysis.
Application of Molecularly Imprinted Polymers in Plant Natural Products: Current Progress and Future Perspectives
Authors: Zuo Jiale , Ma Peirong , Li Zheng , Zhang Yanling , Xiao Douxin , Wu Haixia , Dong Alideertu 
Published: October 2022

AbstractPlants, as a large and complex system, are rich in a variety of natural bioactive constituents. It is crucial to enrich, isolate, purify and detect these natural products. Molecularly imprinted polymers (MIPs) are a class of polymers prepared by molecularly imprinted technology (MIT) that have specific recognition sites and are complementary to templates in shape, size, and binding groups. The synthesis and polymerization mechanism of MIPs are introduced. A variety of preparation methods for MIPs have been developed. MIPs can be classified into three types: non‐covalent molecularly imprinted, covalent molecularly imprinted, and semi‐covalent molecularly imprinted. MIPs usually consists of five parts: template, functional monomer, cross‐linker, initiator, and solvent/reagent. With the advantages of high‐specificity binding ability, MIPs have shown excellent efficacy in the separation, enrichment, and purification of plant active products, such as flavonoids, polyphenols, terpenoids, and other components, especially as specific adsorbent materials. Due to the high selectivity to target the analytes, MIPs have also been used as sensors to detect the bioactive constituents in plants. Undeniably, MIPs still face undeniable limitations in the application of plant natural products. The development of MIPs with high selectivity, strong affinity, cost‐effectiveness, sensitivity, and environmental friendliness are valuable and promising.
Association of Coffee and Tea Consumption with Cardiovascular Disease, Chronic Respiratory Disease, and their Comorbidity
Authors: Chen Yanchun , Zhang Yuan , Yang Hongxi , Ma Yue , Zhou Lihui , Lin Jing , Hou Yabing , Yu Bin , Wang Yaogang 
Published: October 2022

ScopeSince associations between coffee and tea consumption with cardiovascular disease (CVD) and chronic respiratory disease (CRD) remain controversial. This study aims to investigate the separate and combined associations of coffee and tea consumption with CVD, CRD, and their comorbidity.Methods and resultsWithin the UK Biobank, 390 039 participants (56.2 ± 8.1 years) free of CVD and CRD are included. Coffee and tea consumption are self‐reported at baseline. During a median follow‐up of 12.1 years, 31126 CVD, 34132 CRD, and 6071 CVD‐CRD comorbidity cases are identified. J‐shaped associations between coffee and tea consumption with CVD, CRD, and CVD‐CRD comorbidity are observed (p for nonlinearity <0.001). Compared with neither coffee nor tea consumption, hazard ratios (HRs) and 95% confidence intervals (CIs) of combined consumption of moderate coffee and tea (each 2–3 cups per day) are 0.88 (0.81–0.96) for CVD, 0.78 (0.72–0.84) for CRD, and 0.74 (0.61–0.91) for CVD‐CRD comorbidity.ConclusionModerate consumption of coffee and tea separately or in combination are associated with lower risks of CVD, CRD, and their comorbidity.