bluuebunny/crossref_metadata_2025_split huggingface dataset:
Substance Use Disorder Risk Assessment: Preventing Use Disorder
Authors: Arscott Karen E. , Eget Donna M. , Marcos Maria C. , Piper Brian J. 
Published: December 2022

AbstractImportanceCurrent screening tools for Alcohol Use Disorder (AUD) or Substance Use Disorder (SUD) discover this disease at a late stage.ObjectiveThe goal of this study was to develop a simple prevention screening tool for patients who may be prone to develop AUD and/or SUD prior to the development of addiction.DesignThe study involved a self-administered survey type study using a cross-sectional design and was carried out in the spring of 2020 over a one-month period.SettingThis study was completed at an urgent care facility which supports a separate Medication Assisted Treatment (MAT) clinic. Those patients who presented to the MAT clinic (SUD group) were seen in a separate area that the patients presenting for urgent care (Control group).ParticipantsParticipants (N = 259) were voluntarily recruited from MAT and Urgent care patients: Patients receiving acute care were assigned to the Control group (N = 126, 50.8% female, 5.7% non-white, 27.2 age < 34)) and those receiving treatment for SUD were assigned to the MAT group (N =133, 40.8% female, 4.8% non-white, 36.8% <34)).Main Outcome and MeasureThe survey questioned demographics (4 items), risk factors for AUD/SUD (6 items), information about first alcohol/opioid experiences (16 items), and factors for seeking AUD/SUD treatment and recovery (2 items). Feelings were categorized as positive (e.g., euphoria, happiness, self-confident), neutral (e.g., nothing, normal), or negative (e.g., depressed, sad, sick).ResultsThe MAT group felt more positive feelings with first usage of alcohol and opioids compared to the control group (p<.001). With first usage of opioids specifically, MAT (0.13 + 0.04) and Control (0.29 + 0.07, p <.001) groups differed. Over half (55.3%), of the MAT participants reported feeling self-confident with first use of alcohol while only 29.7% of the Control reported this (p<.001). Over three-fifths (63.7%)of the MAT group reported feeling of euphoria with the first usage of opioids compared to one-tenth (9.8%) in the Control group (p<.001).ConclusionsThis retrospective cross-sectional report shows the first affective responses to substances may predict risk for future SUD and could be used as a prevention screening tool. Reporting positive feelings with first usage of alcohol and opioids could be used as a screening tool for patients who may be more prone to developing AUD and SUD.Key PointsQuestionIs there a way to identify a person at risk for developing a substance use disorder?FindingsIn this retrospective cross-sectional study involving 259 participants it was significantly demonstrated that the first affective responses to recreational drugs may predict risk for future drug misuse potentially leading to SUD. The MAT group felt more positive feelings with first usage of alcohol and opioids compared to the comparison group (p < .001).MeaningIf a patient develops a euphoric response to initial experience with a substance, they are significantly more likely to develop a substance use disorder.
Metatranscriptome of infected root canals in teeth with apical periodontitis
Authors: Pinheiro Ericka T. , Russo Giancarlo , Candeiro George T. M. , Vilela Bruna G. , Gomes Brenda P. F. A. , Attin Thomas , Karygianni Lamprini , Thurnheer Thomas 
Published: December 2022

AbstractMetatranscriptomics has not yet been applied to the study of the endodontic microbiome. Therefore, this study investigated the microbial composition and patterns of gene expression in teeth with asymptomatic apical periodontitis. We performed next-generation, microbiomewide RNA-sequencing in eight root canal samples, including five primary and three secondary endodontic infections. Proteobacteria, Bacteroidetes, Firmicutes and Actinobacteria represented the dominant phyla, whereas Fusobacteria, Spirochaetes and Synergistetes were among the non-dominant phyla. At species level, the microbiome was dominated by Gram-negative and Gram-positive anaerobes. In particular,Prevotellaspp. andOlsenella uliwere more abundant in primary than in secondary infections. Transcripts encoding moonlighting proteins were abundant, including glycolytic proteins, translational elongation factors, chaperonin, and heat shock proteins.Fusobacteriumwas highly active in primary infections, showing upregulation of genes involved in protein synthesis, responses to oxidative stress and resistance to antibiotics, especially tetracycline. In addition, other members of the community expressed high numbers of antimicrobial resistance genes. Overall, metatranscriptomics revealed the expression of putative virulence factors and the activity of potential endodontic pathogens, represented mainly by obligate anaerobes. In particular, the functional role ofFusobacteriumin primary infections was highlighted. Furthermore, antimicrobial resistance, especially to tetracycline, was a common feature in endodontic samples.
Neuron- and microglia-specific immunoexpression in steroid-independent male sexual behaviour in castrated B6D2F1 male mice
Authors: Chiang Vic Shao-Chih , Lipkin Sophie , McCusker Catherine D , Park Jin Ho 
Published: December 2022

AbstractSexual behaviour is necessary for procreation for several species and is traditionally viewed to be regulated by sex steroid hormones. However, several species exhibit steroid-independent sexual behaviour, and its molecular understanding is only beginning to be uncovered. The main goal of our experiment was to provide new insight into cell-specific roles that both neuronal and non-neuronal cells may play in steroid-independent male sexual behaviour. Forty B6D2F1 hybrid male mice underwent orchidectomy and were tested for reinstatement of steroid-independent male sexual behaviour after an extended period of social isolation caused by the COVID-19-mandated laboratory shutdown. After 62 weeks post-orchidectomy, 20.59% demonstrated reinstatement of steroid-independent male sexual behaviour (identified as ‘steroid-independent persistent maters’), while 23.53% of the males did not display steroid-independent male sexual behaviour (identified as ‘steroid-independent non-maters’). Using flow cytometry, we compared the preoptic area immunoexpression in NeuN+ neurons and Iba1+ microglia between steroid-independent persistent maters and steroid-independent non-maters (N = 5-6 per group). We found neuronal immunoexpression up-regulated for amyloid precursor protein and androgen receptor, as well as down-regulated for glucocorticoid receptor in steroid-independent persistent maters compared to steroid-independent non-maters. In conjunction, microglial immunoexpression of amyloid precursor protein was up-regulated in steroid-independent persistent maters compared to steroid-independent non-maters. These data suggest there are cell-specific immunoexpression differences, including the role of non-neuronal cells in steroid-independent male sexual behaviour.
The role of Macao's universities in the education and training development of Hengqin
Authors: Wang Wanli , Johnny F.I.Lam , Li Jiagui , Yang Zhenjie 
Published: December 2022

PurposeThis study intends to explore the opportunities and roles of Macao's universities in the education and training development of Hengqin under the General Plan of the Development of the Guangdong–Macao In-Depth Cooperation Zone in Hengqin promulgated in August 2021.Design/methodology/approachThis study is intended to analyze the role of Macao’ universities in Hengqin development, based on data collected through interviewing with dozens of scholars and government officials from Macao and Hengqin, and government reports, news reports and other relevant data.FindingsThe General Plan provides Macao's universities with opportunities to develop education and training in Hengqin. On the one hand, Hengqin can be the locus of Macao's tertiary education diversification; Macao's universities can jointly establish technological research institutions and set up postdoctoral research centers and university branches to enroll master's and doctoral students from Mainland China. On the other hand, Macao's universities can set up a branch of professional training and open training courses in Hengqin. These efforts are designed to promote technological innovation and cultural diffusion in Macao.Originality/valueThis study analyses the potential role of Macao's universities in developing education and training in Hengqin since the central policy was announced last August. This study will be of interest to scholars as well as policymakers.
Vertical line extensions: consumers' preferences for downward and upward extensions
Authors: Shirai Miyuri 
Published: December 2022

PurposeResearch on vertical line extensions shows that consumers tend to evaluate upward extensions higher than downward ones. This paper examines the opposite situation. It also investigates the process underlying consumer responses by identifying a moderator and mediators.Design/methodology/approachTwo studies were conducted to assess the effect of extension direction (upward vs downward) on consumers' extension evaluations. Study 1 incorporated implicit theories of relationships (the growth belief) as a moderator and inferred motives for launching a vertical line extension as mediators in the effect. Study 2 presented a firm's rationale for undertaking the extension to examine whether it influenced evaluations.FindingsConsumers' preferences for downward over upward extensions appeared in markets where the exclusivity of luxury brands had been reduced. However, the resistance to upward extensions was weaker when consumers endorsed stronger growth beliefs in human relationships. Consumers inferred customer- and selling-oriented motives more strongly from downward than upward extensions, enhancing the evaluations. Finally, when presenting a rationale for launching an extension in the launch announcement, customer-oriented reasoning raised the evaluations higher than selling-oriented reasoning but did not elevate the evaluations higher than the announcement showing no reason.Originality/valueThis study advances the literature on vertical line extensions and shows that consumers' preference for upward over downward extensions is not universal. The opposite pattern exists in markets with a lower distinction between high- and low-end brands. It supports the theoretical notion that responses are driven by the differences in growth belief and in cognitive inferences vis-à-vis motives.
Strategic internal communication for effective internal employer branding
Authors: Pološki Vokić Nina , Tkalac Verčič Ana , Sinčić Ćorić Dubravka 
Published: December 2022

PurposeAlthough internal communication is perceived as one of the crucial elements for favorable internal evaluation of an employer brand (EB), the importance of internal communication for EB advocacy has been insufficiently theoretically problematized and related empirical evidence is almost non-existent. In this paper, the relationship between employees' satisfaction with internal communication and their perceptions of their employers' attractiveness is explored.Design/methodology/approachA questionnaire-based field research study was conducted on a sample of 3,457 Croatian employees. The Internal Communication Satisfaction Questionnaire (ICSQ) (Tkalac Verčič et al., 2009) and the Employer Attractiveness (EmpAt) Scale (Berthon et al., 2005) were used for assessing internal communication satisfaction (ICS) and employer attractiveness (EA).FindingsFindings reveal that respondents' overall satisfaction with internal communication in their organizations is significantly positively related with the overall attractiveness they assign to their employers, that all explored ICS dimensions are significant for the overall EA, and that each ICS dimension is significant for at least one EA dimension. The most relevant ICS dimensions for EA are “satisfaction with feedback” and “satisfaction with communication climate”.Originality/valueA conducted large sample study is among the first quantitative empirical studies that proved that employees who are satisfied with internal communication are likely to see their employers as attractive. Moreover, findings point toward internal communication endeavors which add more value to developing an attractive internal EB.
Untangling operational performance implication of ambidextrous blockchain initiatives: an empirical investigation of Chinese manufacturers
Authors: Tse Ying Kei , Wang Shiyun , Liu Xiaohong , Wu Chun Ho 
Published: December 2022

PurposeBlockchain has been considered as a disruptive technology and every industry stands to benefit from it. According to Deloitte, increasing number of managers claim that their firms will suffer loss in competitive advantage if they do not adopt blockchain. Despite this motivation, insufficient knowledge on how can blockchain add value inhibits the commitment to its adoption. To better understand the possible influence of blockchain, two dimensions (exploitation and exploration) of blockchain initiatives are distinguished. This research aims to examine the impact of ambidextrous blockchain initiatives on firms' operational efficiency, as well as the moderating role of unabsorbed slack and environmental munificence.Design/methodology/approachIn this paper, secondary panel data were collected from multiple sources to test the proposed hypotheses. Content analysis was adopted to operationalise ambidextrous blockchain initiatives from firms' official announcements.FindingsThe authors find that firms' ambidexterity in blockchain initiatives have significantly positive impact on operational efficiency. Furthermore, when firms have lower unabsorbed slack or in more munificent environments, they may benefit from managing a balance between exploration and exploitation.Originality/valueThis research offers some insightful theoretical and managerial implications of ambidextrous blockchain initiatives. The findings of this study contribute to blockchain literature by providing theory-driven empirical research.
The value co-creation journey: a longitudinal process unfolding in a network through collaboration
Authors: Perna Andrea , O’Toole Thomas , Baraldi Enrico , Gregori Gian Luca 
Published: December 2022

Purpose
This study aims to develop our understanding of the value co-creation process in business networks. This study identifies four key sub-processes that characterize the value co-creation journey as it unfolds across an inter-organizational network. These four sub-processes are opportunity co-creation, solution co-creation, complementary co-creation and activated co-creation.

Design/methodology/approach
Reflecting the exploratory nature of this research, the methodology relies on an in-depth case study, which is analyzed through the lens of the resource interaction occurring within the specific business relationships and collaborative episodes that affected the nine-year long development of Deko, a new architectural lighting solution.

Findings
The main contribution of the paper is identifying the sub-processes comprising the value co-creation journey of a technology development solution based on resource combining, re-combining and un-combining across a business network. That value co-creation occurs through a time-consuming journey requiring multiple episodes of collaboration can also inspire the practice of handling this process for instance for a small business such as the one featured in this case study.

Originality/value
This paper highlights that the value co-creation journey process has the potential to frame the unfolding of collaboration in practice for a small business.
How augmented reality can improve e-commerce website quality through interactivity and vividness: the moderating role of need for touch
Authors: Kim Seeun , Park Hyejune , Kader Mohammad Shahidul 
Published: December 2022

PurposeThis paper aims to propose a conceptual model to examine the effect of an augmented reality (AR)–based product display (vs a picture-based product display) on interactivity, vividness, website quality and consumer responses. In addition, the moderating role of the need for touch (NFT) in the effect of AR on media features is identified.Design/methodology/approachHypotheses are tested using a one-factor between-subjects design for both a student sample (Study 1, N = 120) and a nonstudent sample (Study 2, N = 272). Data are analyzed using a series of analyses of variance, multivariate analyses of covariance and structural equation modeling.FindingsStudy 1 shows that an AR-based product display generates greater website quality, interactivity and vividness than a picture-based product display. Moreover, an AR-based product display improves interactivity and vividness only for high-NFT consumers; however, no significant difference emerged for low-NFT consumers. Study 2 replicates and extends our findings by identifying the specific processes that consumers go through when evaluating a website.Originality/valueThe current research advances the understanding of how product presentation technologies can attract customers with different haptic orientations and provides practical implications for online retailers interested in improving their customers' e-commerce experience.
Supply chain integration and firm performance in the COVID-19 era: the mediating role of resilience and robustness
Authors: Hendijani Rosa , Norouzi Mahdis 
Published: December 2022

Purpose
In recent years, the COVID-19 pandemic has become one of the most impactful disruptions which has imposed high levels of uncertainty on supply chains around the world. Supply chain integration (SCI) is highly recommended as an underlying mechanism that can facilitate the development of resilience and robustness as two dynamic capabilities. They can in turn positively influence firm performance and success during the disruptive conditions of COVID-19 era. The study aims to examine whether SCI as an enabler of resilience and robustness can improve firm performance during COVID-19 pandemic.

Design/methodology/approach
A theoretical model is developed to elaborate the relationship between SCI dimensions, resilience and robustness and firm’s operational and financial performance during the COVID-19 pandemic. A survey method is then used to empirically examine the model using a sample of 94 companies in the food industry in the province of Tehran, Iran, during the COVID-19 pandemic. This study makes several contributions. It provides a novel theoretical model on the relationship between SCI, resilience and robustness and firm performance and tests this model in a less-studied yet critical context (i.e. Iranian food industry) and during a disruptive era (i.e. COVID-19 pandemic).

Findings
The results support the positive effect of three SCI dimensions of internal, product and process integration on operational and financial performance during corona virus pandemic. Furthermore, internal and process integration have positive effects on resilience. Internal, product and process integration have positive effects on robustness. In addition, resilience mediates the effects of internal and product integration on both operational and financial performance, whereas robustness mediates the effect of internal and product integration on financial performance.

Research limitations/implications
This study was conducted in the Province of Tehran. To test and generalize the results, it is recommended to conduct this study in other places and countries.

Originality/value
These results highlight the importance of SCI dimensions as vital enablers of resilience and robustness and their consequent impact on firm’s performance during the COVID-19 pandemic.
Asynchronous learning: a general review of best practices for the 21st century
Authors: Varkey Thomas Chandy , Varkey John A. , Ding Jack B. , Varkey Philip K. , Zeitler Colton , Nguyen Anne M. , Merhavy Zachary I. , Thomas Charles Ryan 
Published: December 2022

PurposeThe purpose of this paper is to create a “go-to-guide” of best practices in the creation of asynchronous courses. Due to the global pandemic, millions of students around the world transitioned from in-class instruction to online programs, which ranged from completely synchronous classrooms to completely asynchronous classrooms. Students were forced to learn how to engage within an online classroom environment with minimal notice and instructors were abruptly thrusted into a different operational environment, with many required to construct educational ecosystems in an unfamiliar and digitized interface. This led to several actions and the utilization of a multitude of different teaching techniques, many of which were poorly implemented.Design/methodology/approachKey words, “Asynchronous learning”, “Learning”, “Feedback”, “Online Instruction”, and “Classroom Design” were searched in online data bases (Google Scholar, PubMed, EBSCO and Data Base of Open Access Journals). These then were read by the authorial team and authoritative papers were selected by the team based on the frequency of utilization by other papers in the field and the utility of these papers for the design of asynchronous courses.FindingsThis paper explores asynchronous learning from the perspective of how instructional science and learning science can be applied to create the best classroom for both pupil and instructor.Originality/valueIt looks to provide a go-to-guide for best practices in asynchronous learning and the development of K-12 classrooms, graduate and medical school classrooms and finally continuous medical education classrooms. Finally, this guide looks to facilitate the development of master instructors through statements on how to properly provide feedback to students.
Review: Monitoring of land cover changes and plant phenology by remote‐sensing in East Asia
Authors: Shin Nagai , Saitoh Taku M. , Takeuchi Yayoi , Miura Tomoaki , Aiba Masahiro , Kurokawa Hiroko , Onoda Yusuke , Ichii Kazuhito , Nasahara Kenlo Nishida , Suzuki Rikie , Nakashizuka Tohru , Muraoka Hiroyuki 
Published: December 2022

AbstractTo achieve a sustainable society and solve the problems caused by climate change and socioeconomic activities, it is necessary to monitor the spatial and temporal variability of ecosystem functions, services, and biodiversity at both regional and global scales. During the last decade, we have seen rapid and significant improvement in satellite and near‐surface remote‐sensing technologies. In this review, we describe how remote‐sensing observations are being used to effectively evaluate the spatial and temporal variability of land use and cover types and of plant phenology in East Asia. We discuss the current status, uncertainties, problems, and future perspectives for terrestrial ecosystem and biodiversity monitoring, and we address the multidisciplinary research by incorporating in situ and satellite observations for East Asia. Recent satellites with advanced optical sensors, such as MultiSpectral Instrument/Sentinel‐2A/2B, Advanced Himawari Imager/Himawari‐8, and PlanetScope, and satellites with synthetic aperture radar, such as Advanced Land Observing Satellite‐2, allow detailed monitoring of land use and cover type changes and plant phenology. These satellite sensors can provide images with high spatial (3–10 m) and high temporal (10 min to 5 days) resolution, at both large (≥1 km2) and small (<1 km2) scales. In particular, researchers are expected to develop discrimination techniques that will enable these advanced satellite technologies to detect evergreen broadleaf trees and ways to estimate the geographic distribution of leaf traits. We encourage more collaborations among ecologists, engineers, and remote‐sensing scientists to share their abundant knowledge and experience and thereby improve the monitoring capabilities.