bluuebunny/crossref_metadata_2025_split huggingface dataset:
effectiveness of Soderm® – forte gel and a new injectable dosage form of Rexod® in the complex treatment of experimental periodontitis in rats
Authors: Galenko-Yaroshevsky Pavel A. , Kristina V. Tseluiko , Leontev Valeriy K. , Zadorozhniy Mark A. , Popkov Viktor L. , Zelenskaya Anait V. , Babichev Sergey A. , Zadorozhniy Andrey V. , Meladze Sonya V. 
Published: April 2022

Introduction: Insufficient effectiveness of traditional drug therapy in a treatment of patients with chronic generalized periodontitis, as well as high social significance of this problem, determines the need to search for new drugs and their compositions aimed at solving it.
Aim of the study: To increase the efficacy of complex treatment of periodontitis with the administration of Soder­m®-Forte gel and a new injectable form of Rexod®.
Materials and methods: Experiments were performed in 50 male Wistar rats. Experimental periodontitis (EP) was simulated by ligation of the necks of lower incisors. We studied the animals with intact periodontium, untreated EP, and when traditional drug therapy (TDT), as well as the combinations of TDT with Soderm®-Forte gel and additionally with the new injectable dosage form (NIF) of Rexod® were administered. The general condition, behavior, nutrition and body weight of the animals were evaluated. The Schiller-Pisarev test and the Muhlemann-Cowell bleeding index were used, and the amount of crevicular fluid (CF) was measured. The contamination of the marginal gum with microorganisms was determined.
Results and discussion: The TDT in EP has a moderate therapeutic effect, which does not lead to a sufficiently high pharmacotherapeutic effect, whereas the combinations of TDT with Soderm®-Forte and, to a greater extent, TDT with Soderm®-Forte and NIF of Rexod® have high therapeutic efficacy, which is statistically confirmed by a sharp decrease in the amount of CF, the Schiller-Pisarev test and the Muhlemann-Cowell bleeding index, as well as absolute suppres­sion of pathogenic microorganisms.
Conclusion: The combinations of TDT with Soderm®-Forte gel and NIF of Rexod® in EP in rats can significant­ly increase the effectiveness of the treatment. The data obtained indicate the expediency of the administration of Soderm®-Forte gel, as well as its combination with NIF of Rexod® in dental practice in the complex therapy of patients with periodontitis.
Zeev Sternhell, Juif, historien, sioniste
Authors: Leschi Didier 
Published: April 2022

L’auteur retrace sommairement dans cet article la vie du grand historien israélien Zeev Strenhell, décédé au printemps 2020. Il y voit aussi bien dans son parcours d’historien attaché à la France que dans ses engagements civiques un exemple type du « juif hérétique », qui bouscule les pensées établies et permet de faire progresser notre savoir collectif.
« La bibliothèque la plus intelligente du monde »
Authors: Cœuré Sophie , Morder Robi , Rolland-Diamond Caroline 
Published: April 2022

À l’occasion du quarantième anniversaire de l’Association des amis de La contemporaine, fondée en 1981 comme Association des amis de la BDIC, l’article propose quelques réflexions sur son fonctionnement original. Il développe une comparaison avec d’autres groupes d’amis de bibliothèques ou de musées, en lien étroit avec le projet d’un « laboratoire d’histoire internationale contemporaine » unique pour mieux comprendre le monde contemporain. Des documents issus des archives de l’association sont publiés.
Des conditions d’application du règlement Bruxelles I bis
Authors: d’Ornano Antoine 
Published: April 2022

L’article 5, paragraphe 1, du règlement (UE) n o 1215/2012 du Parlement européen et du Conseil, du 12 décembre 2012, concernant la compétence judiciaire, la reconnaissance et l’exécution des décisions en matière civile et commerciale, lu en combinaison avec le considérant 3 de ce règlement, doit être interprété en ce sens que celui-ci s’applique aux fins de la détermination de la compétence internationale des juridictions d’un État membre pour connaître d’un litige opposant un travailleur d’un État membre n’exerçant pas de fonctions relevant de l’exercice de la puissance publique à une autorité consulaire de cet État membre située sur le territoire d’un autre État membre.
Les banques centrales au défi de la transition écologique
Authors: Scialom Laurence 
Published: April 2022

Les banques centrales ont dans l’histoire fait preuve d’une extrême plasticité quant à leur mandat, à leur doctrine et à leurs modalités d’interventions. Nous montrons que la prise en compte de la soutenabilité climatique s’inscrit dans la continuité de cette adaptation permanente aux évolutions du contexte macroéconomique et institutionnel dans lequel elles agissent. Nous présentons ensuite les principaux arguments en faveur de cette extension du mandat des banques centrales à la question climatique. Enfin, nous analysons les dispositions opérationnelles et les instruments que ce nouveau central banking « vert » pourrait promouvoir en matière de politique monétaire et de politique macroprudentielle. Classification JEL : N20, E58, Q58.
Les cash transfers à l’épreuve de l’intermédiation administrative en Ouganda
Authors: Jacquin Ronan 
Published: April 2022

Comment les modèles voyageurs sont-ils adaptés localement ? Quel rôle joue l’intermédiation administrative ? Quelle réception en font les publics cibles ? L’article propose des réponses à ces questions à travers l’étude d’un programme de pensions pour personnes âgées en Ouganda et d’une perspective de policy feedbacks. Les autorités politiques et administratives des districts occupent une place importante dans la mise en œuvre du programme, et entretiennent des rapports de domination paternaliste avec les bénéficiaires. Cette domination paternaliste influence la manière dont ces derniers perçoivent la pension, comme une faveur et non comme un droit. Les bénéficiaires se sentent ainsi redevables d’une dette morale, par laquelle les autorités parviennent à orienter, mais sans contraindre, leurs usages de la pension.
Circulations des travailleuses du sexe balkaniques autour de la Méditerranée
Authors: Tarrius Alain 
Published: April 2022

De 2007 à 2019, 47 000 femmes des Balkans ont migré vers le Levant espagnol pour le travail du sexe. À partir de 2013, 17 000 d’entre elles sont revenues dans leurs pays d’origine avec un capital global de 6,8 milliards d’euros. Cinq profils de femmes nous décrivent leurs investissements dans l’hôtellerie, la coiffure, l’esthétique, l’agriculture, après un séjour moyen de six années. Ces témoignages, parmi lesquels se détache celui de l’Albanaise Archangella, alias Sardinella, croisent des analyses menées par l’auteur depuis 1987 sur la construction de réseaux de circulation et commerce en poor to poor dans l’espace euro-méditerranéen. Partant des récits, les figures présentent la circulation de ces femmes, encadrée par des formations criminelles et mafieuses, puis leur retour et investissements dans les pays d’origine donnant lieu à un modèle paradoxal de développement.
L’IPC à l’épreuve du kéré
Authors: Enten François 
Published: April 2022

Cet article interroge les modalités et effets de mise en épreuve d’un dispositif international d’évaluation de sécurité alimentaire et de nutrition, le Cadre intégré de classification de la sécurité alimentaire (IPC) qui est un modèle voyageur basé sur un « consensus technique » dont les résultats sont diffusés par les médias. Il décrit les multiples distorsions qui surviennent dans le contexte institutionnel malgache face à la faim chronique (kéré) et à son aggravation dans la région du Grand Sud. Il montre comment sa gestion centralisée, son protocole standard et sa complexité freinent l’adoption de ses résultats et de ses diagnostics par les décideurs et les médias pour le déclenchement des réponses aux urgences.
Impact of COVID-19 on Patient-Provider Communication in Critical Care: Case Reports
Authors: Scibilia Stephanie J. , Gendreau Sarah K. , Towbin Rachel Toran , Happ Mary Beth 
Published: April 2022

Introduction
Communication impairment during mechanical ventilation and prolonged critical illness is extremely frustrating and frightening for patients and increases the risk for miscommunication, misinterpretation, and poor outcomes. The COVID-19 pandemic amplified patient communication impairment in intensive care units. This article presents 3 case examples from the experience of a team of hospital-based speech-language pathologists providing augmentative and alternative communication support resources and services to intensive care unit patients treated for COVID-19 during the first wave of the pandemic. Cases were selected to illustrate the protracted and complex in-hospital and rehabilitative recovery of critically ill patients with COVID-19, necessitating creative problem-solving and nursing collaborations with speech-language pathologists to support patient-provider communication.

Clinical Findings
The cases demonstrate (1) increased need for bilingual communication resources, (2) impaired cognitive and motor function associated with a variety of post–COVID-19 sequelae including severe critical illness myopathy, and (3) delayed transition to a speaking valve due to the secretion burden.

Diagnoses
COVID-19 and acute respiratory distress syndrome (all), cerebral microhemorrhage, multi-system organ failure, hypoxic brain injury, altered mental status, seizure, stroke.

Interventions
Multimodal and progressive augmentative and alternative communication interventions included low-technology strategies and simple communication boards, video language interpretation, tracheostomy speaking strategies, and a video intercom system.

Outcomes
All patients made progressive gains in communication ability.

Conclusion
Evaluation by augmentative and alternative communication specialists and progressive intervention from speech-language pathologists in collaboration with intensive care unit nurses can greatly improve patient-provider communication during treatment for and recovery from COVID-19 and other prolonged critical illnesses.
Heterogeneous Integration on 2.3D Hybrid Substrate Using Solder Joint and Underfill
Authors: Tsun-Sheng Chou Ricky , Lau John H. , Chang-Fu Chen Gary , Yu-Cheng Huang Jones , Cheng-Lin Yang Channing , Liu Hsing-Ning , Tseng Tzyy-Jang 
Published: April 2022

Abstract
In this study, the heterogeneous integration of two chips on a 2.3D hybrid substrate using solder joint and underfill is investigated. Emphasis is placed on the materials, design, process, fabrication, and reliability of the package. Drop test and results of the package are also provided.
IL CENTRO NAZIONALE DI ADROTERAPIA ONCOLOGICA: INNOVAZIONI TECNICO-SCIENTIFICHE E NUOVE PROSPETTIVE DELLA BNCT PER LA LOTTA AI TUMORI
Authors: Rossi Sandro , Vago Gianluca 
Published: April 2022

Protons and carbon ions (hadrons) have useful properties for the treatments of patients affected by oncological pathologies. They are more precise than conventional X-rays and possess radiobiological characteristics suited for treating radio-resistant or inoperable tumors. This paper gives an overview of the status of hadron therapy around the world. It focusses on the Italian National Centre for Oncological Hadron therapy (CNAO), describing the centre and the expansion projects. There is growing evidence that supports safety and effectiveness of hadron therapy for a variety of clinical situations. However, there is still a lack of high-level evidence directly comparing hadron therapy with modern conventional radiotherapy techniques. The results give an overview of pre-clinical and clinical research studies and of the treatments of 3700 patients performed at CNAO. The success and development of hadron therapy is strongly associated with the creation of networks among hadron therapy facilities, clinics, universities and research institutions.
Lipid-lowering effect of Oroxylum indicum (L.) Kurz extract in hyperlipidemic mice
Authors: Hengpratom Tanaporn , Kupittayanant Sajeera , Churproong Seekaow , Eumkeb Griangsak 
Published: April 2022

Objective:
To investigate the effect of Oroxylum indicum fruit extract on high-fat diet-induced hyperlipidemic mice.

Methods:
The phytochemical composition of Oroxylum indicum fruit extract was determined by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) and gas chromatography-mass spectrometry. Forty-two male mice were used. The mice were divided into six groups: normal control, high-fat diet control, simvastatin treatment (20 mg/kg BW/day), and Oroxylum indicum fruit extract (100, 200, 300 mg/kg BW/day) treatment groups. Food intake, body weight, serum parameters, lipid profile, and histopathological lesions of the kidney, liver, and epididymal fat were observed.

Results:
LC-MS/MS results revealed four major components of Oroxylum indicum fruit extract: luteolin, apigenin, baicalein, and oroxylin A. Twenty-seven volatile oils were identified from Oroxylum indicum fruit extract. Daily oral administration of Oroxylum indicum fruit extract at 100 to 300 mg/kg BW/day significantly reduced the body weight, total cholesterol, triglyceride, and low-density lipoprotein cholesterol level (P<0.05), whereas high-density lipoprotein cholesterol was higher than the high-fat diet control group. Treatment with 300 mg/kg BW/day Oroxylum indicum fruit extract reduced the pathological lesion and prevented fat accumulation in the kidney and liver.

Conclusions:

Oroxylum indicum fruit extract has hypolipidemic effect in hyperlipidemic mice, and the active ingredients of Oroxylum indicum fruit extract, both flavonoids and volatile oils, should be further explored as an antihyperlipidemic agent.
Anti-obesity effect and UHPLC-QTOF-MS/MS based metabolite profiling of Solanum nigrum leaf extract
Authors: Aabideen Zain Ul , Mumtaz Muhammad Waseem , Akhtar Muhammad Tayyab , Raza Muhammad Asam , Mukhtar Hamid , Irfan Ahmad , Raza Syed Ali , Nadeem Muhammad , Ling Yee Soon 
Published: April 2022

Objective:
To evaluate the antioxidant potential and pancreatic lipase inhibitory action of optimized hydroethanolic extracts of Solanum nigrum.

Methods:
Optimized extraction for maximum recovery of metabolites was performed using a combination of freeze-drying and ultrasonication followed by determination of antioxidant and antiobesity properties. The ultra-high performance liquid chromatography equipped with mass spectrometry was used to analyze metabolite profiling of Solanum nigrum. Computational studies were performed using molecular docking and electrostatic potential analysis for individual compounds. The hypolipidemic potential of the most potent extract was assessed in the obese mice fed on fat rich diet.

Results:
The 80% hydroethanolic extract exhibited the highest extract yield, total phenolic contents, total flavonoid contents along with the strongest 2,2-diphenyl-1-picrylhydrazyl scavenging activity, total antioxidant power, and pancreatic lipase inhibitory properties. The 80% hydroethanolic extract not only regulated the lipid profile of obese mice but also restricted the weight gain in the liver, kidney, and heart. The 80% hydroethanolic extract also reduced alanine transaminase and aspartate transaminase concentrations in serum. The effects of plant extract at 300 mg/kg body weight were quite comparable with the standard drug orlistat.

Conclusions:

Solanum nigrum is proved as an excellent and potent source of secondary metabolites that might be responsible for obesity mitigation.
ENDOTRAKEAL TÜP VEYA TRAKEOTOMİ İLE MEKANİK VENTİLASYON UYGULANAN HASTALARIN AĞIZ HİJYENLERİNİN KARŞILAŞTIRILMASI
Authors: SARAÇ Nalan , MEHEL Dursun Mehmet , KARAÇUHA SÜRÜCÜ Rümeysa , MEHEL Asuman 
Published: April 2022

Amaç: Çalışmanın amacı, yoğun bakım ünitelerinde endotrakeal entübasyonlu şekilde mekanik ventilatöre bağımlı yatan ve akabinde cerrahi trakeotomi açılarak trakeotomi kanülünden mekanik ventilatöre devam edilen hastaların oral kavitelerini trakeotomi öncesi ve sonrasında Eilers Oral Değerlendirme Ölçeğini kullanarak karşılaştırmaktır.
Yöntem: Aralık 2019-Nisan 2020 tarihleri arasında hastanemiz yoğun bakım ünitelerinde endotrakeal entübayon ile mekanik ventilatöre bağlı yatan hastalara cerrahi trakeotomi açılmadan önce ve açıldıktan 7- 12 gün sonra ağız hijyenleri Eilers Ağız Değerlendirme Ölçeği kullanılarak değerlendirildi. Ölçek ses, yutma, dudaklar, dil, tükrük, mukoza, diş eti ve diş değerlendirilmesini içeren sekiz bölümden oluşmaktadır. Ölçeğin her bölümündeki sorulara iyiden kötüye 1,2,3 puan verilmektedir. Yoğun bakımda mekanik ventilatöre bağlı hastalarda ses ve yutma değerlendirilemediğinden diğer altı bölümün değerlendirilmesi yapıldı.
Bulgular: Çalışmaya 20 (%54.0) erkek, 17 (%46.0) kadın toplam 37 hasta dahil edildi. Hastaların yaşları 18 ile 86 arasında değişmekte olup ortalama 68.28±13.6 idi. Hastaların tamamında trakeotominin uzamış entübasyon nedeniyle açıldığı saptandı. Trakeotomi açılan hastaların ilk trakeotomi kanül değişimlerinin 7 ile 12 gün arasında ortalama 7.4’üncü günde yapıldığı tespit edildi. Trakeotomi sonrası takip edilen hastaların 5’inin ilk 10 gün içinde kaybedildiği saptandı. Eilers ölçeği ile trakeotomi öncesi ve sonrası oral hijyenleri değerlendirilen hastalarda oral hijyende iyileşme olmasına rağmen bu iyileşme istatistiksel olarak anlamlı bulunmadı.
Sonuç: Yoğun bakımlarda, endotrakeal entübasyonla mekanik ventilatöre bağlı hastalarda düzenli ağız bakımına ilaveten mekanik ventilasyona trakeotomi açılarak devam edilmesi oral hijyende iyileşmeye mahal vermektedir. Bunun desteklenmesi için geniş katılımlı, prospektif çalışmalar gerekmektedir.
COVİD-19 PANDEMİSİNDE ÜNİVERSİTE ÖĞRENCİLERİNİN DEĞİŞEN YAŞAMLARI VE ONLİNE (ÇEVRİMİÇİ) EĞİTİMLERİ ÜZERİNE BİR ARAŞTIRMA
Authors: ÇAMUR Gülsüm , ERSANLI Ercümend , ABUKAN Bilge , CANIM Fatma 
Published: April 2022

Amaç: Covid-19 pandemisine bağlı olarak ortaya çıkan değişimlerin üniversite öğrencilerinin eğitim yaşamlarına doğrudan etkileri olmuştur. Bu kapsamda eğitim süreci ağırlıklı olarak online / çevrimiçi devam etmiştir. Bu nedenle üniversite öğrencilerinin bu süreci nasıl değerlendirildiğinin anlaşılması önemli görülmektedir.
Yöntem: Bu araştırmada Covid-19 pandemisinin üniversite öğrencilerinin yaşamlarına, duygu ve düşüncelerine, aile ilişkilerine yansımaları ve online derslerin verimliliği/etkililiği betimsel tarama modeli kullanılarak incelenmiştir. Araştırmaya pandemi sürecinde online eğitime devam eden 185 sosyal hizmet lisans öğrencisi dahil edilmiştir. Verilerin istatistiksel çözümlemelerinde sayı ve yüzdelik incelenmiş; açık uçlu sorularda içerik analizi yapılmıştır.
Bulgular: Araştırma bulgularında öğrencilerin Covid-19 sürecinde sağlık sorunlarına ilişkin bilgilere, öğrencilerin pandemi ile yaşamlarında karşılaştıkları değişimlere, pandemi ile ortaya çıkan duygu tanımlarına, pandemi sürecinde yaşamı anlamlandırma biçimlerine, değişen aile ilişkilerine ve online derslere yönelik öğrencilerin görüşlerine yer verilmiştir.
Sonuç ve Öneriler: Araştırma sonuçları pandemi sürecinde öğrencilerin sadece eğitim yaşamlarının değil, psikososyal yaşamlarının, aile yaşamlarının ve aile içi ilişki yapılarının, ekonomik yaşamlarının da etkilendiğini ortaya koymaktadır. Bu sonuçlar öğrencilerin karşılaştıkları sorunların çözümü için çeşitli desteklere gereksinim duyduklarını göstermektedir. Diğer yandan hem öğrencilerin hem de öğretim elemanlarının teknolojik yeterliliklerinin ve olanaklarının geliştirilmesi ve eğitim kurumlarının işlevlerinin yeniden değerlendirilmesi önemli görülmektedir.
Types of 3D Printers Applied in Industrial Pharmacy and Drug Delivery
Authors: Al-Gawhari Fatima Jalal , Mohammed Ali Ali A. 
Published: April 2022

The promising technology depend on using 3D printers' machines (3DPs) might be considered a modern approach in drug industry and delivery. A 3D printer may define as a machine which fabricates 3D models or products using computer aided design (CAD) software programs. These printers can create a single copy of an item that is too complicated and very difficult to produce by using traditional manufacturing methods. Moreover, it has ability to make products with complex internal structure geometries with lower cost and time. Recently, 3D printers have been involved into printing bio-products, custom pills and organs for transplant. This review presents the types of 3DPs suitable for drug industry and delivery. There are several types of 3DPs are used in pharmaceutical fields including inkjet (IK) printers, fused filament (FF) type printers, extrusion and hot melt extrusion 3D printing, sintering by selective kind of laser (SLS), Stereolithography (SLA), melting by micro selective laser (SLM), binder applied jetting printing (BJ) and the laminated object engineering manufacturing (LOM).
THE ROLE OF DYNAMIC LUMBAR SPINE X-RAY IN THE DIAGNOSIS OF TYPE 1 SPONDYLOLISTHESIS IN PATIENTS WHO HAVE PREVIOUSLY DONE LUMBAR SPINAL SURGERY.
Authors: Shah Syed Nasir , Shah Walayat , Ali Saad , Khan Sajid , Jamal Bakth , Ullah Imran , Qazi Zia Ullah , Ul Haq Naeem 
Published: April 2022

Objective: To determine the role of dynamic lumbar spine x-ray in the diagnosis of type 1 spondylolisthesis in patients who have previously done lumbar spinal surgery.
Materials and Methods: The study was carried out at neurosurgery department, Lady Reading Hospital Peshawar, KPK from July 2015 to June 2017. He study employed prospective observational) study and a total of 1440 patients were studied.
Results: A total of 1440 patients were studied in which 974 (67.7%) were females and the remaining 464 (33.3%) were males. Mean age of the patients was between 20 to 50 years. These patients had underwent lumbar spinal surgery about 1 year ago for PIVD and Stenosis. Proper history was taken and relevant examination was done. These patients were suggested dynamic lumbar spinal x-ray .After dynamic lumbar spinal x-ray (flexion extension view) was done, it was revealed that around 672 (46.6 %) of the total 1440 patients had type 1 spondylolisthesis. This percentage of patients with type 1 spondylolisthesis is prove of how dynamic lumbar spinal x-ray plays a role in the diagnosis of type 1 spondylolisthesis in patients who have had underwent lumbar spinal surgery.
Recommendation: Dynamic lumbar spinal x-ray is recommended as a standard technique in the diagnosis of type 1 spondylolisthesis in patients who had previously underwent lumbar spinal surgery.
Pelaksanaan Supervisi Kepala Sekolah dalam Meningkatkan Kinerja Guru di Sekolah Dasar
Authors: Silfatman Yusril , Lilianti Lilianti , Nurzaima Nurzaima 
Published: April 2022

Rumusan masalah dalam penelitian ini yaitu bagaimanakah pelaksanaan kepala sekolah dalam meningkatkan kinerja guru di SD Negeri 39 Pulau Tambako Kabupaten Bombana, bertujuan untuk mengetahui dan menghasilkan pelaksanaan supervisi kepala sekolah untuk meningkatkan kinerja guru di SD Negeri 39 Pulau Tambako. Teknik pengumpulan data dengan menggunakan observasi, wawancara dan dokumentasi. Teknik analisis data yaitu: pengumpulan data, reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukan bahwa program supervisi dan instrumen dalam melaksanakan supervisi yang dimiliki SD Negeri 39 Pulau Tambako dibuat secara bersama-sama antara kepala sekolah dengan para guru. Pelaksanaan supervisi dimulai dengan memeriksa program pembelajaran yang dimiliki guru. Selanjutnya kepala sekolah memberi jadwal kapan beliau akan melaksanakan supervisi dalam melaksanakan tugas mengajarnya didalam kelas. Selain itu diadakan pertemuan individual antara kepala sekolah dan guru untuk mendiskusikan hasil supervisi. Lebih lanjut dalam pertemuan tersebut kepala sekolah memberikan saran dan solusi terbaik untuk memperbaiki dan meningkatkan kualitas guru kelas yang bersangkutan.