bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental health professionals’ awareness of the parental functioning of persons with severe mental disorders: a retrospective chart study
Authors: Eliezer Shahar , Efron Martin , Mendlovic Shlomo , Gal Gilad , Lurie Ido 
Published: October 2022

AbstractBackground:The proportion of persons with severe mental illness (SMI) who are parents has increased in recent decades. Children of parents with SMI are at increased risk for medical, behavioral, emotional, developmental, academic, and social problems. They also have an increased risk for injuries, accidents, and mortality, addictions, and various psychiatric disorders compared to children of parents with no such diagnoses. We aimed to examine the extent to which mental health professionals (MHPs) who treat adult patients with SMI in ambulatory settings are aware of these individuals’ functioning in three parenting domains: parental functioning, familial support system and children’s conditions. We also compared psychiatrists’ awareness with that of psychologists and social workers.Methods:In this retrospective practice-oriented study, we reviewed 80 clinical files of individuals diagnosed with schizophrenia, affective disorder or personality disorder treated in a mental health outpatient clinic, using the Awareness of Family’s Mental Health Checklist (AFMHC) developed for this study. Thus, awareness was determined on the basis of what was recorded in the patient file.Results:Almost half of the MHPs were unaware to their patients’ parental functioning as only 44% of files contained records relating to this issue. Awareness to other domains was even lower: 24% of files contained information on patient’s support system and 12% had information about their children’s mental and/or physical health. No statistically significant differences between psychiatrists and other MHPs were found with regards to awareness to the various domains. Positive correlations were found among MHP’s for awareness in the three domains.Conclusion:Lack of awareness among MHPs to their patients’ parental functioning is not specific to a certain profession and may be attributed to patients (e.g., reluctance to disclose relevant information) or to MHPs (e.g., lack of training). Awareness of family and parental functioning by MHPs working with persons with SMI should be part of a standard procedure, integrated into policy and training.
Efficacy and safety of Tripterygium wilfordii polyglycosides for diabetic kidney disease: an overview of systematic reviews and meta-analyses
Authors: Wang Ying , Han Mei , Li Yao-Tan , Wang Zhen , Liu Jian-Ping 
Published: October 2022

Abstract
Background
Recently, several systematic reviews (SRs) and meta-analyses (MAs) of Tripterygium wilfordii polyglycoside (TWP) have reported significant benefits on diabetic kidney disease (DKD). However, the adoption of TWP for DKD remains uncommon. This study aimed to evaluate and summarize the current evidence on TWP for DKD.

Methods
We searched PubMed, Web of Science, SINOMED, Embase, Cochrane Library, CNKI database, Wan Fang database, and VIP database, up to June 4, 2022. SRs of TWP on DKD were included. Two authors independently assessed eligibility, extracted data, and graded the quality of evidence. We appraised the reporting and methodological quality of the included studies based on the PRISMA statement and AMSTAR 2.

Results
We included 19 SRs and MAs. Seventeen MAs of proteinuria were identified; all suggested TWP exhibited anti-proteinuria function on DKD. Of these, only 2 were graded as moderate quality of evidence. Eighteen MAs estimated the reno-protective effect of TWP; nine of them showed that TWP improved renal function, including 2 MAs rated as moderate quality of evidence. Eleven SRs showed the serum albumin level was elevated in the TWP group. Of those, four were rated as moderate quality of evidence. Fourteen MAs of the incidence of adverse events were included. Twelve MAs indicated TWP increased the risk of adverse events, of which 4 were graded with moderate quality of evidence. Twenty of the 27 items in the PRISMA checklist were adequately reported with more than 75% compliance among the included SRs, while five of the 12 items in the PRISMA checklist for abstract were found to have less than 50% compliance. The overall reporting quality of SRs published in English was higher than that in Chinese. The methodological quality of the included SRs appraised by AMSTAR-2 ranged from critically low to moderate.

Conclusion
TWP appears effective for DKD on improving proteinuria and increasing the level of serum albumin, accompanied by a higher risk of adverse events. The evidence would be more credible and valuable to guide decision if the quality of the SRs and primary studies is improved.

Systematic review registration
PROSPERO CRD42021249560
Screening for Fabry’s disease in a high-risk subpopulation of FMF
Authors: Maller Tomer , Ben-Zvi Ilan , Lidar Merav , Livneh Avi 
Published: October 2022

AbstractBackgroundFamilial Mediterranean fever (FMF) is an autosomal recessive disease associated with mutations in the Mediterranean fever gene (MEFV) that manifests with recurrent episodes of febrile serositis. Fabry’s disease (FD) is an X-linked lysosomal storage disease caused by mutations in thealpha-galactosidase Agene and presents with a wide range of gastrointestinal, skin, vascular, renal and neurological manifestations. FMF and FD share similar manifestations, which may lead to misdiagnosis of one as the other; mostly FD is misdiagnosed as FMF. Moreover, various overlapping manifestations may stem from comorbidities, commonly coupled to FMF (such as Behcet's disease, inflammatory bowel disease, glomerulonephritis, fibromyalgia, and multiple sclerosis), as well as from colchicine adverse effects, which may add to the diagnostic confusion. Thus, we postulated that screening FMF for FD will lead to the identification of patients falsely diagnosed with FMF or who, in addition to FMF, suffer from FD that was previously missed.MethodsTo identify missed FD among the FMF population, we performed chemical and genetic analyses for FD in blood samples obtained from a cohort of FMF patients followed in the specialized FMF center of our institution. To increase the likelihood of detecting patients with FD, we enriched the surveyed FMF population with patients exhibiting manifestations shared by patients with FD or who deviate from the typical FMF presentation.Results and conclusionsOf 172 surveyed FMF patients in a cohort derived from a clinic dedicated to FMF, none had FD. Thus, the postulation of increased odds for detecting FD in patients with FMF was not confirmed. Further exploration for FD in FMF population, is nevertheless recommended.
rs2013278 in the multiple immunological-trait susceptibility locus CD28 regulates the production of non-functional splicing isoforms
Authors: Hitomi Yuki , Aiba Yoshihiro , Ueno Kazuko , Nishida Nao , Kawai Yosuke , Kawashima Minae , Tsuiji Makoto , Iwabuchi Chisato , Takada Sanami , Miyake Noriko , Nagasaki Masao , Tokunaga Katsushi , Nakamura Minoru 
Published: October 2022

AbstractBackgroundLigation of CD28 with ligands such as CD80 or CD86 provides a critical second signal alongside antigen presentation by class II major histocompatibility complex expressed on antigen-presenting cells through the T cell antigen receptor for naïve T cell activation. A number of studies suggested that CD28 plays an important role in the pathogenesis of various human diseases. Recent genome-wide association studies (GWASs) identifiedCD28as a susceptibility locus for lymphocyte and eosinophil counts, multiple sclerosis, ulcerative colitis, celiac disease, rheumatoid arthritis, asthma, and primary biliary cholangitis. However, the primary functional variant and molecular mechanisms of disease susceptibility in this locus remain to be elucidated. This study aimed to identify the primary functional variant from thousands of genetic variants in theCD28locus and elucidate its functional effect on the CD28 molecule.ResultsAmong the genetic variants exhibiting stronger linkage disequilibrium (LD) with all GWAS-lead variants in theCD28locus, rs2013278, located in the Rbfox binding motif related to splicing regulation, was identified as a primary functional variant related to multiple immunological traits. Relative endogenous expression levels ofCD28splicing isoforms (CD28i and CD28Δex2) compared with full-length CD28 in allele knock-in cell lines generated using CRISPR/Cas9 were directly regulated by rs2013278 (P < 0.05). Although full-length CD28 protein expressed on Jurkat T cells showed higher binding affinity for CD80/CD86, both CD28i and CD28Δex2 encoded loss-of-function isoforms.ConclusionThe present study demonstrated for the first time thatCD28has a shared disease-related primary functional variant (i.e., rs2013278) that regulates the CD28 alternative splicing that generates loss-of-function isoforms. They reduce disease risk by inducing anergy of effector T cells that over-react to autoantigens and allergens.
Intervention during wait time: identification and referral of individuals non-adherent for colorectal cancer screening
Authors: Abar Beau , Park Chanjun Syd , Dalawari Preeti , Klausner Howard , Ogedegbe Chinwe , Valassis Steven , Koneswaran Haran , Adler David , Bradley Keith 
Published: October 2022

Abstract
Background
Despite unanimous recommendations from numerous specialty societies on regular colorectal cancer screening, a substantial proportion of eligible adults are non-adherent with screening. The current study investigated whether research associates (RAs) in the emergency department (ED) can adequately assess patients’ adherence with colorectal cancer screening recommendations, outlined by the US Preventive Services Task Force (USPSTF), and provide referrals to individuals who are found to be non-adherent.

Methods
RAs at seven heterogeneous hospitals in the USA queried non-emergent adult patients and visitors between the ages of 50 and 75. After obtaining verbal consent, the participant’s adherence with USPSTF guidelines for colorectal cancer screening was assessed. Participants found due for screening were provided with referrals to obtain these recommended screenings.

Results
A total of 8258 participants were surveyed on their colorectal cancer screening status, with RAs identifying 2063 participants who were not adherent with USPSTF guidelines for colorectal cancer screening and 67 for whom adherence could not be determined (total 27%).

Conclusions
Our study demonstrates that RAs can identify a large volume of eligible adults who would benefit from colorectal cancer screening across a variety of emergency department settings.
The microdistribution of fluid and its effect on pore structure in shale: A case study of lacustrine Chang 7 shale, Ordos Basin
Authors: Wu Chenhui , Tang Xuan , Li Xiaoguang , Zhang Bin , Li Pei , Jiang Zaixing , Liu Yang , Kong Xiangfei , Du Kefeng , Zhang Jinchuan 
Published: October 2022

The pore fluid distribution in nanosized pores in shale cannot be observed directly with the current observation equipment which makes it difficult to study the fluid behavior in the shale pore system. To better understand pore fluid evolution and distribution in shale and its effect on pore structure with increasing maturity from immature to oil windows, a serial of samples with different maturity have been collected from the Lower Triassic lacustrine clay-rich Chang 7 shale in the Ordos Basin and treated with oven drying and sequential extraction to remove water, mobile oil, and asphaltene. We have measured the pore-size distributions in the presence of different pore fluids by using the mercury intrusion and N2 adsorption and desorption testing. The results indicate that (1) the pores in the clay-rich samples are mostly slit-shaped mineral pores, consist of a small number of macropores (pore size >50 nm) and a large number of mesopores (pore sizes between 7 and 36 nm), and also including a small amount of poorly developed organic matter-hosted pores. (2) Different types of pore fluids appear to occupy different pore-size ranges. Water prefers to occupy the mineral mesopores. Mobile oil (extracted by n-hexane) is mostly distributed in 2–10 nm-sized organic-matter-hosted mesopores. Asphaltenes are mostly distributed in mesopores in the range of 25–36 nm. (3) The presence of pore fluid significantly impacts the pore structures of shale. The pore volume and specific surface area decrease due to pore fluid occupation, even for low-maturity samples in which the organic matter pores also are developed but cannot be observed under a scanning electron microscope. (4) Organic matter abundance and thermal maturity have significant effects on the pore fluid composition and distribution. With increasing maturity, water is gradually displaced by oil due to hydrocarbon generation and accumulation in large mineral pores.
Architectural Element Analysis of Nonmarine Oil and Gas Reservoir in China, the Research History, Progress and Future Trend: A Review
Authors: Zhang Changmin , Yin Taiju , Wu Shenghe , Yin Yanshu , Feng Wenjie , Li Yang , Jia Ailin , Lin Chengyan , Ma Shizhong , Hu Guangyi 
Published: October 2022

Since Miall’s architectural element analysis (AEA) was introduced to China in 1986, the method has been widely applied to studying the heterogeneity of oil and gas reservoirs in China. The development history, research field, research progress, and potential limitations of AEA in China have been reviewed based on 601 Chinese documents retrieved from the China National Knowledge Infrastructure (CNKI) database and some English documents retrieved from various databases. The development of sedimentary AEA in China experienced four stages: (1) the conceptual and introduction stage (1985–1995), (2) the test and trial stage (1995–2005), (3) the popularization and application stage (2005–2015), and (4) the innovative stage (2015 to present). The research field covers all reservoir types of continental petroliferous basins in China. Papers published on AEA were distributed in the fields of (1) alluvial fan reservoirs, (2) braided channel reservoirs, (3) meandering channel reservoirs, (4) fan delta reservoirs, (5) braided river delta reservoirs, (6) shallow-water delta reservoirs, (7) large-scale delta reservoirs, (8) beach and bar reservoirs, and (9) lacustrine deepwater gravity flow reservoirs. Among all these fields, the architecture of alluvial fans, braided channels, meandering channels, braided river delta, and fan delta reservoirs was mainly researched. AEAs in China have made outstanding innovations in hierarchical sedimentary boundary surface classification, depositional architectural models, and quantitative reservoir architectural modeling. Combining the hierarchical AEA with geostatistical modeling, big data, and artificial intelligence technology and comprehensively using geology, geophysics, and production information to realize the hierarchical integrated reservoir architectural characterization are the development directions of the AEA in China and around the world.
Analysis of processes leading to explosive phenomena on the surface of a liquid cathode at the time of the dc electric arc ignition
Authors: Tereshonok D. V. , Sargsyan M. A. , Gadzhiev M. Kh. , Karchugaeva Z. G. 
Published: October 2022

Abstract
The paper considers various causes of explosions on the cathodes surface in the region of arc attachment in a direct current arc discharge. Estimates of the characteristic times of the development of instabilities during the passage of current through the liquid tip of the cathode are made. As a result, an assumption was put forward that, starting from the moment of formation of the stretched tip and up to the explosion, at different stages of the stretches development, various instabilities alternately play the main roles.
China-Russia Bilateral Security and Military Partnership in Changing World Order: Security Challenges for the United States of America in Asia and Beyond
Authors: Bharti Mukesh Shankar 
Published: October 2022

The objective of this research is to assess the defence partnership of Russia and China after the Cold War period. This study analyses the military cooperation and strategic relation of Russia and China in the post-Cold War period. Further, the article highlights the main contradicting areas between the United States of America (USA) and the Russia-China alliance in international politics. It also elucidates the Russia-China relationship across the diplomatic paradigm and economic aspects in the global economic system. China’s flagship economic New Silk Road Initiative is a challenging concept for the US on land and maritime across the world. Thus, the study uses the research question: how do China and Russia compete with the US challenges in the new world order? The qualitative comparative method is used to investigate answers to the research questions and objectives of this study. This article attempts to use an analytical framework to describe the countries’ vision for joint development in the area of security issues. Russia and China have deep military cooperation and commit to working together against the US domination in the Asia Pacific and other parts of the world. In a conclusion it is stated that Russia and China have been accelerating bilateral military cooperation in a positive direction, which is a success story between both countries, and the US is facing stiff competition in Asia as well as in the Asia Pacific Region (APR).
Quality of death and its related factors in terminally ill patients, as perceived by nurses
Authors: Matchim Yaowarat , Thongthawee Borwarnluck , Raetong Parinya , Kanhasing Ruankwan 
Published: October 2022

Background:Little is known about the quality of death of terminally ill patients in hospitals in Thailand.Aim:To examine the quality of death of terminally ill patients and investigate correlations between the quality of death and the organisational climate; nurses' palliative care knowledge; nurses' palliative care practice; and nurses' perceptions of barriers in providing palliative care.Methods:A cross-sectional survey design was used. Data collected among 281 nurses were analysed by descriptive statistics, Pearson correlation and Spearman's rank correlation.Results:The overall quality of death of terminally ill patients in the hospital was moderate. Organisational climate and nurses' palliative care practice positively correlate with terminally ill patients' quality of death. Nurses' difficulty in providing palliative care negatively correlates with terminally ill patients' quality of death.Conclusion:Promoting an organisational climate and enhancing nurses' palliative care practice may improve the quality of death of terminally ill patients in this hospital.
Influenza vaccination coverage among an urban pediatric asthma population: Implications for population health
Authors: Parker Sarah J. , DeLaroche Amy M. , Hill Alex B. , Arora Rajan , Gleason-Comstock Julie 
Published: October 2022

Introduction
Asthma is the most common chronic disease in children. Children with asthma are at high risk for complications from influenza; however annual influenza vaccination rates for this population are suboptimal. The overall aim of this study was to describe the characteristics of a high-risk population of children with asthma presenting to an urban pediatric emergency department according to influenza vaccination status.

Methods
The study was a retrospective chart review of 4355 patients aged 2 to 18 years evaluated in a Michigan pediatric emergency department (PED) between November 1, 2017 and April 30, 2018 with an ICD-10-CM code for asthma (J45.x). Eligible patient PED records were matched with influenza vaccination records for the 2017–2018 influenza season from the Michigan Care Improvement Registry. Geospatial analysis was employed to examine the distribution of influenza vaccination status.

Results
1049 patients (30.9%) with asthma seen in the PED had received an influenza vaccine. Influenza vaccination coverage varied by Census Tract, ranging from 10% to >99%. Most vaccines were administered in a primary care setting (84.3%) and were covered by public insurance (76.8%). The influenza vaccination rate was lowest for children aged 5–11 years (30.0%) and vaccination status was associated with race (p<0.001) and insurance type (p<0.001).

Conclusions
Identification of neighborhood Census Tract and demographic groups with suboptimal influenza vaccination could guide development of targeted public health interventions to improve vaccination rates in high-risk patients. Given the morbidity and mortality associated with pediatric asthma, a data-driven approach may improve outcomes and reduce healthcare-associated costs for this pediatric population.
Consequences of the Corona crisis on outpatient oncological care – a qualitative study among nurses and medical assistants
Authors: Kaiser Ulrich , Vehling-Kaiser Ursula , Schmidt Jörg , Hoffmann Ana , Kaiser Florian 
Published: October 2022

Introduction
The Covid-19 pandemic has caused great personal stress for medical staff. To ensure adequate outpatient care for cancer patients, extensive safety and hygiene measures must be taken. This interview-based study examines the effects–both personal and professional–of the pandemic on the work routine of outpatient hematology/oncology nurses and medical assistants.

Patients, materials and methods
Half a year after the outbreak of Covid-19 and the introduction of infection control regulations in three outpatient hematological/oncological centers, the affected medical staff (n = 15) were surveyed about the consequences for patient care and clinical work using audio-recorded telephone interviews. The interviews were transcribed and analyzed using a qualitative content analysis.

Results
The Covid-19 pandemic has complicated the medical care of cancer patients, but only a slight deterioration of medical and psycho-oncological care was observed. The level of stress experienced by medical staff is moderate, with hygiene and safety measures at the workplace helping to reduce stress.

Conclusion
From the point of view of medical staff, the Covid-19 pandemic has had a moderate impact on the outpatient care of cancer patients. Safety measures against Covid-19 are decisive for ensuring the continuation of therapy and for motivating employees.
Wahrnehmungen der Fluchtmigration aus postmigrantischer Perspektive – Allianzen, Antagonisten und Ambivalenzen in Everswinkel
Authors: Schrobenhauser Maximilian , Leszczynski Nora , Mertens Leonard , Mlejnek Marius , Lütke Petra 
Published: October 2022

For this paper, the perception of the integration of refugees in the community of Everswinkel (North Rhine-Westphalia) was traced from a post-migrant perspective. For this purpose, representatives of the community, volunteers and residents of suburban neighbourhoods were asked about the changed situation of refugee migration since 2015. In order to arrive at a broader perspective on migration, which no longer sees immigration as a downstream problem affecting only migrants, but rather as a condition to be negotiated for the entire host society, the conceptual triad of alliances, antagonists and ambivalences of Naika Foroutan was operationalized. The results of the surveys turned out to be very heterogeneous and some contradicting views of integration were observed. On the one hand, diverse pro-plural alliances have emerged in Everswinkel, which materialize in particular in the offers and institutions of the community. On the other hand, these are accompanied by anti-plural antagonists who are, for example, strongly conveyed through topics such as neighbourhood coexistence or the topic of living. In addition, a third perspective, that of the ambivalence and contradictions in the perception of the integration of refugees, comes into focus.