bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of Ulnar Neuropathic Pain with Peripheral Nerve Stimulation: Two Case Reports
Authors: Langford Brendan , D’Souza Ryan S , Pingree Matthew , Mauck William D 
Published: October 2022

Abstract
Ulnar neuropathy is a condition that manifests with symptoms of neuropathic pain, numbness, tingling, and even possible motor deficits in the ulnar distribution of the arm. This debilitating painful condition may be refractory to conservative, pharmacologic, and surgical interventions. Peripheral nerve stimulation (PNS) technology has advanced significantly in recent years allowing for conditions such as ulnar neuropathy to be treated in a minimally invasive manner. Here we report the first case reports in the literature (to our knowledge) of two patients with intractable ulnar neuropathy who underwent minimally invasive PNS Bioventus implants. Both patients experienced at least 75% pain relief based on NRS scores at 6 months after ulnar nerve PNS implantation. The patients also experienced significant improvement in functional outcomes, including return to employment, ability to perform activities of daily living without any impairment, and improved quality of life measures. While the results presented in our two case reports are promising, we only provide observational data over a 6 to 15-month period post-implantation. Future well-powered, large-scale, and long-term randomized controlled trials are warranted to determine efficacy and long-term pain and functional outcomes from PNS therapy for treatment of ulnar neuropathy.
Velocity of sound beyond the high-density relativistic limit from lattice simulation of dense two-color QCD
Authors: Iida Kei , Itou Etsuko 
Published: October 2022

Abstract
We obtain the equation of state (EoS) for two-color quantum chromodynamics (QCD) at low temperature and high density from the lattice Monte Carlo simulation. We find that the velocity of sound exceeds the relativistic limit ($c_s^2/c^2=1/3$) after BEC-BCS (Bose-Einstein condensation–Bardeen–Cooper–Schrieffer) crossover in the superfluid phase. Such an excess of the sound velocity is previously unknown from any lattice calculations for QCD-like theories. This finding might have a possible relevance to the EoS of neutron star matter revealed by recent measurements of neutron star masses and radii.
Bacterial antibiotic resistance among cancer inpatients in China: 2016–20
Authors: Ju Y , Liu K , Ma G , Zhu B , Wang H , Hu Z , Zhao J , Zhang L , Cui K , He X -R , Huang M , Li Y , Xu S , Gao Y , Liu K , Liu H , Zhuo Z , Zhang G , Guo Z , Ye Y , Zhang L , Zhou X , Ma S , Qiu Y , Zhang M , Tao Y , Zhang M , Xian L , Xie W , Wang G , Wang Y , Wang C , Wang D -H , Yu K 
Published: October 2022

SummaryBackgroundThe incidence of infections among cancer patients is as high as 23.2–33.2% in China. However, the lack of information and data on the number of antibiotics used by cancer patients is an obstacle to implementing antibiotic management plans.AimThis study aimed to investigate bacterial infections and antibiotic resistance in Chinese cancer patients to provide a reference for the rational use of antibiotics.DesignThis was a 5-year retrospective study on the antibiotic resistance of cancer patients.MethodsIn this 5-year surveillance study, we collected bacterial and antibiotic resistance data from 20 provincial cancer diagnosis and treatment centers and three specialized cancer hospitals in China. We analyzed the resistance of common bacteria to antibiotics, compared to common clinical drug-resistant bacteria, evaluated the evolution of critical drug-resistant bacteria and conducted data analysis.FindingsBetween 2016 and 2020, 216 219 bacterial strains were clinically isolated. The resistance trend of Escherichia coli and Klebsiella pneumoniae to amikacin, ciprofloxacin, cefotaxime, piperacillin/tazobactam and imipenem was relatively stable and did not significantly increase over time. The resistance of Pseudomonas aeruginosa strains to all antibiotics tested, including imipenem and meropenem, decreased over time. In contrast, the resistance of Acinetobacter baumannii strains to carbapenems increased from 4.7% to 14.7%. Methicillin-resistant Staphylococcus aureus (MRSA) significantly decreased from 65.2% in 2016 to 48.9% in 2020.ConclusionsThe bacterial prevalence and antibiotic resistance rates of E. coli, K. pneumoniae, P. aeruginosa, A. baumannii, S. aureus and MRSA were significantly lower than the national average.
Screening with Frames: Implementation in Extensive Form
Authors: Ostrizek Franz , Shishkin Denis 
Published: October 2022

Abstract
We study a decision-framing design problem: a principal faces an agent with frame-dependent preferences and designs an extensive form with a frame at each stage. This allows the principal to circumvent incentive compatibility constraints by inducing dynamically inconsistent choices of the sophisticated agent. We show that a vector of contracts can be implemented if and only if it can be implemented using a canonical extensive form, which has a simple high–low–high structure using only three stages and the two highest frames, and employs unchosen decoy contracts to deter deviations. We then turn to the study of optimal contracts in the context of the classic monopolistic screening problem and establish the existence of a canonical optimal mechanism, even though our implementability result does not directly apply. In the presence of naive types, the principal can perfectly screen by cognitive type and extract full surplus from naifs.
Social Media and Financial News Manipulation
Authors: Kogan Shimon , Moskowitz Tobias J , Niessner Marina 
Published: October 2022

Abstract
We examine an undercover Securities and Exchange Commission (SEC) investigation into the manipulation of financial news on social media. While fraudulent news had a direct positive impact on retail trading and prices, revelation of the fraud by the SEC announcement resulted in significantly lower retail trading volume on all news, including legitimate news, on these platforms. For small firms, volume declined by 23.5% and price volatility dropped by 1.3%. We find evidence consistent with concerns of fraud causing the decline in trading activity and price volatility, which we interpret through the lens of social capital, and attempt to rule out alternative explanations. The results highlight the indirect consequences of fraud and its spillover effects that reduce the social network’s impact on information dissemination, especially for small, opaque firms.
Digital power resources (DPR): the political economy of structural and infrastructural business power in digital(ized) capitalism
Authors: Kemmerling Michael , Trampusch Christine 
Published: October 2022

Abstract
Studies on digitalization and business power tend to focus on digital platform firms. In contrast, we argue that data, digital technologies and digital infrastructures create novel digital power resources (DPR) for firms throughout sectors. DPR can be structural, that is, rooted in data and digital technologies, and infrastructural, that is, rooted in digital infrastructure. We propose indicators and apply them to a sample of 120 large firms from the USA, UK, France and Germany, active in five sectors. We find that firms from all sectors control DPR but the sectoral distribution varies depending on the national political–economic context. Lastly, we demonstrate the analytical value added of our concept by explaining variation in business preferences and strategies toward data sovereignty and data-sharing regulation in the German automotive sector. Our DPR concept improves our understanding of why and how business seeks to influence (digital) policies and politics in digital(ized) capitalism in general.
Endogenous giant viruses contribute to intraspecies genomic variability in the model green alga Chlamydomonas reinhardtii
Authors: Moniruzzaman Mohammad , Erazo-Garcia Maria P , Aylward Frank O 
Published: October 2022

Abstract
Chlamydomonas reinhardtii is a unicellular eukaryotic alga that has been studied as a model organism for decades. Despite an extensive history as a model system, phylogenetic and genetic characteristics of viruses infecting this alga have remained elusive. We analyzed high-throughput genome sequence data of C. reinhardtii field isolates, and in six we discovered sequences belonging to endogenous giant viruses that reach up to several 100 kb in length. In addition, we have also discovered the entire genome of a closely related giant virus that is endogenized within the genome of Chlamydomonas incerta, the closest sequenced relative of C. reinhardtii. Endogenous giant viruses add hundreds of new gene families to the host strains, highlighting their contribution to the pangenome dynamics and interstrain genomic variability of C. reinhardtii. Our findings suggest that the endogenization of giant viruses may have important implications for structuring the population dynamics and ecology of protists in the environment.
Endothelial CYP2J2 overexpression restores the BRB via METTL3‐mediated ANXA1 upregulation
Authors: Zhao Bowen , Huang Jingqiu , Lou Xiaotong , Yao Ke , Ye Meng , Mou Qianxue , Wen Zheng , Duan Qiming , Zhang Hong , Zhao Yin 
Published: October 2022

AbstractBlood–retinal barrier (BRB) breakdown is responsible for multiple ocular diseases, such as diabetic retinopathy, age‐related macular degeneration, and retinal vascular occlusive diseases. Increased vascular permeability contributes to vasogenic edema and tissue damage, with consequent adverse effects on vision. Herein, we found that endothelial CYP2J2 overexpression maintained BRB integrity after ischemia–reperfusion injury and consequently protected against retinal ganglion cell loss. Oxidative stress repressed endothelial ANXA1 expression in vivo and in vitro. CYP2J2 upregulated methyltransferase‐like 3 (METTL3) expression and hence promoted ANXA1 translation via ANXA1 m6A modification in endothelium under oxidative stress. CYP2J2 maintained the distribution of endothelial tight junctions and adherens junctions in an ANXA1‐dependent manner. Endothelial ANXA1 plays an indispensable role in vascular homeostasis and stabilization during development. Endothelial ANXA1 deletion disrupted retinal vascular perfusion as well as BRB integrity. CYP2J2 metabolites restored BRB integrity in the presence of ANXA1. Our findings identified the CYP2J2–METTL3–ANXA1 pathway as a potential therapeutic target for relieving BRB impairments.
Nurses' Perceptions of the Clinical Nurse Specialist Role Implemented in a Highly Specialized University Hospital in Spain
Authors: Vázquez-Calatayud Mónica , Oroviogoicoechea Cristina , Rumeu-Casares Carmen , Goñi-Viguria Rosana 
Published: October 2022

Purpose/Aims
To explore nurses' perceptions of clinical nurse specialist practice as implemented in a highly specialized university hospital in Spain.

Design
A descriptive qualitative study was carried out in 3 inpatient wards, with a clinical nurse specialist within the team, at a high specialized university hospital in Spain.

Method
Semistructured interviews were conducted by purposive sampling with 17 selected nurses with at least 2 years of professional experience who voluntarily agreed to participate and signed the informed consent form. Analysis of the qualitative data was conducted according to Burnard's method of content analysis. The Consolidated Criteria for Reporting Qualitative Research checklist was used.

Results
Four main categories emerged from the analysis of the data: “qualities of the role-holder,” “role competencies in practice,” “integration with the team,” and “impact of the role” on nursing, the patient, and the organization.

Conclusions
The findings of this study have interesting implications for the development and implementation of clinical nurse specialist practice in healthcare organizations. They also provide evidence of the benefit of implementing clinical nurse specialist practice for improving the quality of care, patient outcomes, and healthcare efficiency.
Nurses' Knowledge Regarding Nursing Surveillance of the Septic Patient
Authors: LeBlanc Paul , Kabbe Angela , Letvak Susan 
Published: October 2022

Purpose
Sepsis remains a life-threatening condition and leading cause of death in the United States despite vast efforts to understand and treat it. Successful sepsis treatment requires the timely implementation of the sepsis bundle to avoid multiple organ system failure; a key component of sepsis care is nursing surveillance. The purpose of this study was to explore nurses' knowledge of nursing surveillance related to the patient with sepsis and to describe barriers to the implementation of nursing surveillance for sepsis and the sepsis bundle.

Design
A qualitative descriptive design study used focus groups to elicit responses to open-ended questions.

Methods
Focus group interviews with 28 registered nurses were conducted. All focus group participants had a minimum of 6 months' experience caring for patients with sepsis.

Results
Five themes emerged from the study: (1) knowledge deficit of the sepsis bundle and nursing surveillance, (2) uncertain and overwhelmed, (3) lack of resources, (4) in the dark, and (5) lack of partnership/respect. The notion of fearing the patient with sepsis and knowledge deficits of nursing surveillance and sepsis bundle were unique findings.

Conclusions
Findings highlight the need for increased attention on the importance of nurse surveillance of the patient with sepsis.
Pregnant Through the COVID-19 Chaos
Authors: McNamee Lucy C. , Liu Xiaoyu , Phan Kim , Johnson Teresa , Talsma AkkeNeel 
Published: October 2022

Purpose/Aims
To gain insights in how women use technology to address health information needs during the prenatal and postpartum time frame.

Design
An exploratory qualitative study recruited pregnant and recent postpartum women to share their perspectives on information they needed and how they obtained it.

Methods
Women who were pregnant or <90 days postpartum (n = 26) were recruited via social media and invited to share their experiences. Design thinking methodology was used to develop questions to understand information needs in the perinatal period as well as in context of the COVID-19 pandemic. Verbatim transcripts were coded by the research team according to Braun and Clarke's reflexive thematic analysis.

Results
Five themes explain the experience of seeking information to support the perinatal period. Women explained the need for the following: (1) information and relationships are inseparable, (2) current practices leave needs unmet, (3) the pandemic exposes vulnerability in prenatal care, (4) left to figure it out alone, and (5) bridging the gap through technology.

Conclusions
Aggregated findings suggest how usual care can be modified to improve support for women through personalized care, improved information support, and use of technology. The study findings inform innovative strategies using current technologies to improve health promotion in a dynamic health environment.
Implementation of a Standardized Protocol for Telehealth Provider in Triage to Improve Efficiency and ED Throughput
Authors: Fleming Adam , Whitty Kristin 
Published: October 2022

There has been a significant rise in the number of emergency department (ED) visits over the past 15 years despite the number of ED providers and treatment spaces remaining fixed (M. P. Lin et al., 2018). A hospital's need to quickly initiate care upon patient arrival is of paramount importance to combat these ED overcrowding trends. A teleprovider in triage (TPIT) program without a standardized operating protocol leads to significant provider practice variations and limits effectiveness of a TPIT program. The intention of this health care project was to reduce ED time metrics and reduce the number of patients who left before evaluation by implementing a standardized TPIT protocol. This standardization allowed for a more predictable experience for the patient and ED staff. This quality improvement project involved developing and implementing a standardized TPIT protocol to improve TPIT efficiency and throughput. Patient ED visit metrics were collected during the pre- and postimplementation periods to evaluate for any improvement in throughput due to the TPIT protocol. The TPIT advanced practice providers (APPs) showed significant improvement in knowledge following the TPIT protocol education with an increase in provider comfort (p < 0.05). Time spent by the TPIT provider on each patient encounter was reduced by 23%, demonstrating increased provider efficiency. Improvements in discharge lengths of stay (LOS) (p = 0.68) and room to discharge LOS (p < 0.05) were noted following the implementation of the TPIT protocol.

Conclusions:
The implementation of the TPIT protocol provided improvements in APP knowledge and understanding of the process while increasing provider efficiency. Improvements were identified in specific ED patient metrics demonstrating the significance of the TPIT protocol on patient care.
<xhtml:span xmlns:xhtml="http://www.w3.org/1999/xhtml" xml:lang="en">Purpura fulminans secondary to <em>Capnocytophaga canimorsus</em>&#160;bacteraemia following a dog bite: A case report and review of literature.
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Authors: Killington Kieran , Lee Nathaniel , Asher Radha , Farrant Olivia , Stone Neil 
Published: October 2022

Introduction. Infection due to Capnocytophaga canimorsus may result in a wide variety of clinical presentations. We present a case of life-threatening Capnocytophaga canimorsus infection with evolution of ecchymosis to purpura fulminans.
Case description. We present a case of a 43-year-old male with a significant history of alcohol use who presented with features of sepsis following a dog bite. This was associated with a striking, widespread purpuric rash. A causative pathogen, C. canimorsus was identified through blood culture and 16S RNA sequencing. His initially purpuric rash underwent bullous change and was diagnosed clinically as purpura fulminans, confirmed on skin biopsy. He made a full recovery with prompt antimicrobial therapy, initially with amoxiclav/clavulanic acid but escalated to clindamycin and meropenem due to clinical deterioration and concerns of beta-lactamase resistance.
Discussion . b-lactamase producing Capnocytophaga strains are of increasing concern. This particular concern is reflected in our case as five days into treatment with b-lactamase inhibitor combination therapy the patients clinical condition deteriorated but demonstrably improved on switching to a carbapenem.
The development of biopsy proven purpura fulminans in this immunocompetent case is a rare severe manifestation of the previously reported manifestation of DIC in Capnocytophaga septicaemia. The case reported describes characteristics common with other DIC presentations such as the presence of clinical risk factors (history of alcohol excess) and symmetrical involvement. However, an unusual feature in that initial purpuric lesions were followed by the development of a bullous appearance and peripheral necrotic features concerning for purpura fulminans and confirmed with skin biopsy.
Roseovarius carneus sp. nov., a novel bacterium isolated from a coastal phytoplankton bloom in Xiamen
Authors: Sun Xueqiong , Lin Dan , Han Yu , Sun Jia , Ye Jianing , Chen Beihan , Tang Kai 
Published: October 2022

A Gram-stain-negative, non-motile, ovoid or short rod shaped and aerobic marine bacterium, designated as strain LXJ103T, was isolated from a coastal phytoplankton bloom in Xiamen, PR China. Cells were oxidase- and catalase-positive. Strain LXJ103T grew at 4–40 °C (optimum, 28–37 °C), at pH 6–10 (optimum, pH 8.5) and with 1–15 % (w/v) NaCl (optimum, 3 %). The major cellular fatty acids (>10 %) were iso-C18 : 1
ω7c/iso-C18 : 1
ω6c (70.2 %) and C16 : 0 (10.3 %). The following polar lipids were found to be present: phosphatidylglycerol, phosphatidylethanolamine, two unidentified phospholipids and five unknown glycolipids. The predominant respiratory quinone was ubiquinone-10. Strain LXJ103T exhibited the highest 16S rRNA gene sequence similarity to

Roseovarius litorisediminis

D1-W8T (96.97 %). The phylogenetic trees based on 16S rRNA gene sequences showed that strain LXJ103T was a member of the genus

Roseovarius

. The draft genome size of strain LXJ103T is 3.05 Mb with a genomic G+C content of 61.22 mol%. The digital DNA–DNA genome hybridization value of strain LXJ103T compared with the most similar type strain

R. litorisediminis

CECT 8287T was 18.80 %. The average nucleotide identity value between strain LXJ103T and

R. litorisediminis

CECT 8287T was 72.60 %. On the basis of polyphasic data, strain LXJ103T represents a novel species of the genus

Roseovarius

, for which the name Roseovarius carneus sp. nov. is proposed. The type strain is LXJ103T (=CGMCC 1.19168T=MCCC 1K06527T=JCM 34778T).
Gordonia zhenghanii sp. nov. and Gordonia liuliyuniae sp. nov., isolated from bat faeces
Authors: Huang Yuyuan , Gong Jian , Dong Lingzhi , Yang Jing , Lu Shan , Lai Xin-He , Pu Ji , Jin Dong , Xu Jianguo 
Published: October 2022

Four mesophilic actinobacteria (HY002T, HY442, HY366T and HY285) isolated from the faeces of bats collected in southern China were found to be strictly aerobic, non-motile, rod-shaped, oxidase-negative, Gram-stain-positive and catalase-positive. Strains HY002T and HY366T contained meso-diaminopimelic acid as the diagnostic diamino acid and MK-9(H2) the sole respiratory quinone. Arabinose, galactose and ribose were detected in the whole-cell hydrolysates of both type strains. The main cellular fatty acids (> 10.0%) of all strains were C16 : 0, C18 : 1
ω9c, 10-methyl-C18 : 0 and summed feature 3. Strains HY002T and HY366T contained diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylinositol and phosphatidyl inositol mannosides as the major polar lipids. The phylogenetic/phylogenomic analyses based on 16S rRNA gene and genomic sequence comparison revealed that the four strains belong to the genus

Gordonia

, most closely related to

G. neofelifaecis

NRRL B-59395T(98.2–98.3% sequence similarity) on the EzBioCloud database. The G+C contents of strains HY002T and HY366T based on genomic DNA were 66.5 and 66.9%, respectively. The DNA–DNA relatedness values between the two types strains and members of the genus

Gordonia

were far below 70 % (18.6–23.1 %). All genotypic and phenotypic data indicated that the four strains are representatives of two novel separate species, for which the names Gordonia zhenghanii sp. nov. and Gordonia liuliyuniae sp. nov. are proposed, with HY002T (=CGMCC 4 7757T=JCM 34 878T) and HY366T (=CGMCC 1 19146T=JCM 34 879T) as the respective type strains.
Microbial Gene Ontology informed deep neural network for microbe functionality discovery in human diseases
Authors: Liu Yunjie , Zhang Yao-zhong , Imoto Seiya 
Published: October 2022

BackgroundThe human microbiome plays a crucial role in human health and is associated with a number of human diseases. Determining microbiome functional roles in human diseases remains a biological challenge due to the high dimensionality of metagenome gene features. However, existing models were limited in providing biological interpretability, where the functional role of microbes in human diseases is unexplored. Here we propose to utilize a neural network-based model incorporating Gene Ontology (GO) relationship network to discover the microbe functionality in human diseases.ResultsWe use four benchmark datasets, including diabetes, liver cirrhosis, inflammatory bowel disease, and colorectal cancer, to explore the microbe functionality in the human diseases. Our model discovered and visualized the novel candidates’ important microbiome genes and their functions by calculating the important score of each gene and GO term in the network. Furthermore, we demonstrate that our model achieves a competitive performance in predicting the disease by comparison with other non-Gene Ontology informed models.ConclusionsThe discovered candidates’ important microbiome genes and their functions provide novel insights into microbe functional contribution.