bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationships between satisfaction with life, posttraumatic growth, coping strategies, and resilience in cancer survivors: A network analysis approach
Authors: Adamkovič Matúš , Fedáková Denisa , Kentoš Michal , Bozogáňová Miroslava , Havrillová Dominika , Baník Gabriel , Dědová Mária , Piterová Ivana 
Published: May 2022

AbstractObjectiveCancer survivors' satisfaction with life should be seen through the psychological factors related to a person's capabilities to face and handle the situation. This study aimed to (1) examine the relationships of satisfaction with life, posttraumatic growth, resilience and coping strategies in a global network model, (2) find the bridge indicators between satisfaction with life and the other constructs, and (3) test for the invariance of the network structures across several moderating variables.MethodsIn a heterogeneous sample of 696 cancer survivors (69% female; mean age = 53.1 ± 15.44 years; median time from being diagnosed = 4 years; breast cancer was the most frequent type of cancer) their satisfaction with life, resilience, coping strategies and posttraumatic growth was measured. In order to account for their complexity, the relationships between the constructs were explored using a network analysis approach.ResultsThe network analysis shows that satisfaction with life is strongly connected to resilience, moderately connected to coping strategies, and has a weak connection with posttraumatic growth. In the separate networks, the relationships between the psychological constructs were examined in greater detail. Besides some exceptions observed in the degree of disability, the networks were invariant across gender, age, years since being diagnosed, cancer type and treatment type.ConclusionThe findings suggest that interventions focused on cancer survivors' coping strategies and resilience could help increase their satisfaction with life. However, further replication of the proposed and/or modified model is needed.
A descriptive study of commercial herbal dietary supplements used for dyslipidemia—Sales data and suspected adverse reactions
Authors: Allkanjari Olta , Menniti‐Ippolito Francesca , Ippoliti Ilaria , Di Giacomo Silvia , Piccioni Tito , Vitalone Annabella 
Published: May 2022

AbstractHerbal dietary supplements (HDS) used for dyslipidemia represent a category of concern in Italy for suspected adverse reactions (ARs). However, we cannot estimate their safety, as we do not know their commercial profile. Sales data of HDS, and particularly, those used for dyslipidemia, were monitored for 2 years in two pharmacies of Rome. Meanwhile, spontaneous reports of suspected ARs potentially related to dyslipidemia supplements were collected by the Italian Phytovigilance System. The 50% of the total dietary supplements are herbal‐derived; the 9% of HDS are recommended for dyslipidemia. From our data, 113 different brands have claims for improving lipids profile and 91% of them are multiingredient preparations. Fifteen spontaneous reports of suspected ARs concerned HDS used, for dyslipidemia. The most frequent ARs were joint, abdominal, and muscles pain; vomiting; erythema and hematological disorders; nausea; and rhabdomyolysis. Our findings point out the limited compliance of commercial dyslipidemia‐HDS and scientific research about their intrinsic safety. A wide range of ingredients could not support the risk/benefit profile of the supplement. The variable compositions of HDS do not assure the safety, as they do not support the reproducibility of their pharmacological activities. This study could contribute to optimize consumer guidance about what they purchase and consume.
CXCL10 levels in diagnosis and improved hemodynamics in patients with chronic thromboembolic pulmonary hypertension undergoing balloon pulmonary angioplasty
Authors: Hong Cheng , Lu Jianmin , Chen Riken , Liu Haimin , Chen Haiming , Wu Xiaofeng , Guo Wenliang , Huang Zijie , Liao Huizhao 
Published: May 2022

AbstractChronic thromboembolic pulmonary hypertension (CTEPH) is a progressive pulmonary vascular disease characterized by pulmonary artery stenosis or obstructions resulting from insufficient thrombus resolution. Chemokine (C‐X‐C motif) ligand 10 (CXCL10) is a chemokine that contributes to the pathogenesis of many autoimmune diseases and cancers. The present study aims to investigate the levels of CXCL10 in patients with CTEPH throughout balloon pulmonary angioplasty (BPA) and its correlation with the improvement of pulmonary hemodynamics. Plasma CXCL10 levels were measured in 38 CTEPH patients with 100 BPA sessions and in 28 healthy controls. Correlations between CXCL10 and pulmonary hemodynamics were investigated. Receiver operating characteristic (ROC) curves were plotted to display the diagnostic value and the predictive ability for perioperative complications of CXCL10 and CXCL10‐related models. Nomograms were plotted to visualize the diagnostic value and the predictive ability for perioperative complications of CXCL10 and CXCL10‐related models. CXCL10 levels are higher in CTEPH patients compared with healthy controls (36.5 [95% confidence interval {CI}: 25.0–51.1] vs. 14.8 [95% CI: 11.1–30.9], p < 0.0001) and decreased significantly after BPA treatment (36.5 [95% CI: 25.0–51.1] vs. 24.7 [95% CI: 17.2–36.6], p < 0.0005). Preoperative CXCL10 levels positively correlated with mean right atrial pressure (r = 0.25), systolic pulmonary artery pressure (PAP; r = 0.28), diastolic PAP (r = 0.33), mean PAP (r = 0.36), pulmonary vascular resistance (r = 0.31), and N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP; r = 0.46). Furthermore, plasma CXCL10 levels adjusting for age and sex displayed a sensitivity of 86.0% and a specificity of 67.9% for discriminating CTEPH patients from healthy controls. Preoperative CXCL10 levels, in combination with NT‐proBNP, predicted perioperative complications with a sensitivity of 100.0% and a specificity of 46.9% as displayed in ROC analysis. In conclusion, circulating CXCL10 might contribute to the evaluation of disease severity in CTEPH patients and be useful to evaluate the treatment effect of BPA. Future studies are warranted to further study the relationship between pulmonary hemodynamics and circulating CXCL10.
Adaptive event‐triggered H∞ state estimation of semi‐Markovian jump neural networks with randomly occurred sensor nonlinearity
Authors: Lu Hongqian , Xu Yao , Song Xingxing , Zhou Wuneng 
Published: May 2022

AbstractThis article mainly discusses the problem for adaptive event‐triggered H state estimation of semi‐Markovian jump neural networks (s‐MJNNs) subject to random sensor nonlinearity. To reduce the communication load, adaptive event‐triggered scheme (AETS) is introduced to decide whether to transmit sampled data or not. Also, considering the possible sensor nonlinearity, a new estimation error model is established under the framework of AETS. An appropriate Lyapunov–Krasovskii functional (LKF) containing the proposed adaptive event trigger condition is constructed, and sufficient conditions are obtained to guarantee the asymptotic stability of the estimation error system. Then, through a set of feasible linear matrix inequalities (LMIs), the co‐design method of estimator and AETS is proposed. Finally, the feasibility of this paper is proved by three numerical examples.
Effects of different management measures on soil conservation and the influence of environmental conditions: a case study involving UAV remote sensing on the Loess Plateau
Authors: Guo Xingjian , Shao Quanqin , Luo Ying 
Published: May 2022

AbstractTo curb further deterioration due to soil erosion, the Chinese government has successively implemented a series of ecological improvement projects across the Loess Plateau (LP). This study used unmanned aerial vehicle remote sensing combined with the revised universal soil loss equation to quantitatively evaluate the soil conservation rate (SR) under 10 management measures and further incorporated the topographic slope into the analysis to describe the impacts of terrain changes. The results showed that the average SR of plots under artificial management measures was 61.24 ± 0.004% (P < 0.01), whereas that under non‐artificial measures was 47.90 ± 0.007% (P < 0.01), which showed that human activities on the LP beneficially improved the SR. In addition, benefiting from the Grain to Green Project, cultivated fields, and economic forests exist only in areas with gentle slopes, and both these areas experience almost no threat of soil loss. A terraced structure exerts an obvious effect on extremely steep slopes (>40°), and a greater slope is associated with a more evident effect. However, the risk of structural failure also increases. In addition, due to restricted water conditions, the effects of existing soil and water conservation measures that use tree planting as the main method have the characteristics of horizontal and vertical zonation differentiation. Valley bottom and semi‐humid areas are more profitable, and other areas are more suitable for planting drought‐tolerant shrubs. In addition to guiding the deployment of future soil and water conservation measures, this study can provide a theoretical basis for adjusting the existing low‐efficiency measures.
Catch me if you can? Staggered inevitable disclosure doctrine (IDD) rejection and entrepreneurial activity in the US
Authors: Patel Pankaj C. , Devaraj Srikant 
Published: May 2022

AbstractResearch SummaryInevitable disclosure doctrine (IDD) refers to a legal doctrine where an employer can claim, without the need for proof or evidence, misappropriation of trade secrets to seek an injunction against an employee. Based on entrepreneurial spawning literature, for employees seeking to start their ventures, IDD rejection by state courts could therefore be a potential catalyst to entrepreneurial activity. In a sample of neighbor‐counties across state borders with and without IDD rejection, the two‐way fixed‐effects difference‐in‐differences estimates show positive effects for county‐level entrepreneurial outcomes. However, when applying more recently developed methods for testing staggered implementation, we find no support for county‐level entrepreneurial outcomes across multiple specifications and heterogeneities. The findings have implications for the limited efficacy of IDD rejection on regional entrepreneurial activity.Managerial SummaryThe value of protecting trade secrets is important for employers, and the role of laws in preventing employees from potentially disclosing their trade secrets is widely studied. One such legal doctrine is the inevitable disclosure doctrine (IDD) where an employer can claim, without the need for proof or evidence, misappropriation of trade secrets to seek an injunction against an employee. We find that IDD rejections by courts have a limited effect on the formation of startups in a county. The findings imply that investors are less encumbered by IDD rejections by courts and that policymakers may not find IDD rejections as a useful mechanism to prime local entrepreneurship.
Orthogonal array composite designs for drug combination experiments with applications for tuberculosis
Authors: Luna Jose , Jaynes Jessica , Xu Hongquan , Wong Weng Kee 
Published: May 2022

AbstractThe aim of this article is to provide an overview of the orthogonal array composite design (OACD) methodology, illustrate the various advantages, and provide a real‐world application. An OACD combines a two‐level factorial design with a three‐level orthogonal array and it can be used as an alternative to existing composite designs for building response surface models. We compare the ‐efficiencies of OACDs relative to the commonly used central composite design (CCD) when there are a few missing observations and demonstrate that OACDs are more robust to missing observations for two scenarios. The first scenario assumes one missing observation either from one factorial point or one additional point. The second scenario assumes two missing observations either from two factorial points or from two additional points, or from one factorial point and one additional point. Furthermore, we compare OACDs and CCDs in terms of ‐optimality for precise predictions. Lastly, a real‐world application of an OACD for a tuberculosis drug combination study is provided.
Time‐Resolved SAXS Study of Polarity‐ and Surfactant‐Controlled Superlattice Transformations of Oleate‐Capped Nanocubes During Solvent Removal
Authors: Lv Zhong‐Peng , Kapuscinski Martin , Járvás Gábor , Yu Shun , Bergström Lennart 
Published: May 2022

AbstractStructural transformations and lattice expansion of oleate‐capped iron oxide nanocube superlattices are studied by time‐resolved small‐angle X‐ray scattering (SAXS) during solvent removal. The combination of conductor‐like screening model for real solvents (COSMO‐RS) theory with computational fluid dynamics (CFD) modeling provides information on the solvent composition and polarity during droplet evaporation. Evaporation‐driven poor‐solvent enrichment in the presence of free oleic acid results in the formation of superlattices with a tilted face‐centered cubic (fcc) structure when the polarity reaches its maximum. The tilted fcc lattice expands subsequently during the removal of the poor solvent and eventually transforms to a regular simple cubic (sc) lattice during the final evaporation stage when only free oleic acid remains. Comparative studies show that both the increase in polarity as the poor solvent is enriched and the presence of a sufficient amount of added oleic acid is required to promote the formation of structurally diverse superlattices with large domain sizes.
Interface Coordination Stabilizing Reversible Redox of Zinc for High‐Performance Zinc‐Iodine Batteries
Authors: Chen Song , Chen Qianwu , Ma Jizhen , Wang Jianjun , Hui Kwan San , Zhang Jintao 
Published: May 2022

AbstractAqueous Zn batteries (AZBs) have attracted extensive attention due to good safety, cost‐effectiveness, and environmental benignity. However, the sluggish kinetics of divalent zinc ion and the growth of Zn dendrites severely deteriorate the cycling stability and specific capacity. The authors demonstrate modulation of the interfacial redox process of zinc via the dynamic coordination chemistry of phytic acid with zinc ions. The experimental results and theoretical calculation reveal that the in‐situ formation of such inorganic–organic films as a dynamic solid‐electrolyte interlayer is efficient to buffer the zinc ion transfer via the energy favorable coordinated hopping mechanism for the reversible zinc redox reactions. Especially, along the interfacial coating layer with porous channel structure is able to regulate the solvation structure of zinc ions along the dynamic coordination of the phytic acid skeleton, efficiently inhibiting the surface corrosion of zinc and dendrite growth. Therefore, the resultant Zn anode achieves low voltage hysteresis and long cycle life at rigorous charge and discharge circulation for fabricating highly robust rechargeable batteries. Such an advanced strategy for modulating ion transport demonstrates a highly promising approach to addressing the basic challenges for zinc‐based rechargeable batteries, which can potentially be extended to other aqueous batteries.
H2‐Inhibited Organic Anodes for Fast and Long‐Life Aqueous Aluminum Ion Batteries with a 3.5‐Month Calendar Life
Authors: Wang Donghong , Li Qing , Ying Wang , Han Cuiping , Wang Yu , Zhao Yuwei , Li Hongfei , Zhi Chunyi 
Published: May 2022

AbstractAqueous aluminum ion batteries are rarely constructed due to the unworkable Al metal and the preferential H2 evolution. Herein, organic anode with H2‐inhibition is optimized through tuning the polymerization degree and displays a high‐rate and reversible storage of Al ions based on an enolation between Al ions and the carbonyl double bonds on the conjugated structures. The superiority of the optimal sample is researched, which is attributed to the raised state of lowest unoccupied molecule orbital (LUMO) with the doner N–N bridge and relatively small steric hindrance of the dimmer. When paired with active carbon, a high cycling life of 5000 cycles with a retention of 99.2% is obtained. A full battery constructed by this dimer and δ‐MnO2 cathode delivers an average voltage of 1.0 V, high capacity of 263.8 mAh g‐1 based on the mass of δ‐MnO2, and high‐capacity retention of 88.8% after cycling for 300 cycles. More importantly, with a fully eliminated corrosion and passivation in AlCl3 and Al2(SO4)3 electrolytes, a long calendar stability of 104 days is achieved.
Gold‐Nanoparticle‐Mediated Assembly of High‐Order DNA Nano‐Architectures
Authors: Yin Jue , Xie Mo , Wang Junke , Cui Meirong , Zhu Dan , Su Shao , Fan Chunhai , Chao Jie , Li Qian , Wang Lianhui 
Published: May 2022

AbstractConstructing high‐order DNA nano‐architectures in large sizes is of critical significance for the application of DNA nanotechnology. Robust and flexible design strategies together with easy protocols to construct high‐order large‐size DNA nano‐architectures remain highly desirable. In this work, the authors report a simple and versatile one‐pot strategy to fabricate DNA architectures with the assistance of spherical gold nanoparticles modified with thiolated oligonucleotide strands (SH‐DNA‐AuNPs), which serve as “power strips” to connect various DNA nanostructures carrying complementary ssDNA strands as “plugs”. By modulating the plug numbers and positions on each DNA nanostructure and the ratios between DNA nanostructures and AuNPs, the desired architectures are formed via the stochastic co‐assembly of different modules. This SH‐DNA‐AuNP‐mediated plug‐in assembly (SAMPA) strategy offers new opportunities to drive macroscopic self‐assembly to meet the demand of the fabrication of well‐defined nanomaterials and nanodevices.
Atomically Dispersed Fe–N3C Sites Induce Asymmetric Electron Structures to Afford Superior Oxygen Reduction Activity
Authors: Tong Miaomiao , Yu Peng , Xie Ying , Wang Lei , Wang Ying , Fu Honggang 
Published: May 2022

AbstractIntroducing heteroatoms into atomically dispersed Fe–N4 sites with symmetric electron distribution can adjust the imperfect oxygenated adsorption‐activation and promote oxygen reduction reaction (ORR) activity. However, the relevant design synthesis and deeply understanding the electrocatalytic mechanism of such an asymmetric structure by introducing Fe–C coordination remains challenging. Herein, the structural stability of Fe–NxCy (x = 0 ≈ 4, y = 4–x) is first theoretically predicted and indicates that the energy of Fe–N4 in the two most stable structures is greater than that of Fe–N3C. Subsequently, Fe–N4 and Fe–N3C configurations are controlled synthesized by adjusting pyrolytic temperature. The Fe–N3C‐based electrocatalyst displays a boosted ORR activity with a half‐wave potential of 0.91 V and superior long‐term stability, outperforming Fe–N4, Pt/C, and state‐of‐the‐art noble metal‐free electrocatalysts. Density functional theory calculations unveil that Fe–N3C is much more favorable for electron delocalization than Fe–N4. Furthermore, the residual Zn atom derived from ZIF‐8 would give its d‐orbit electron to the Fe atom, so the synergy between Fe–N3C and Zn–N4 makes an enhanced ORR activity.
Extension of the fib MC 2010 for basic and drying shrinkage of alkali‐activated slag concretes
Authors: Caron Richard , Patel Ravi A. , Dehn Frank 
Published: May 2022

AbstractAlkali‐activated slag is an alternative to ordinary Portland cement that has been studied for the past 20 years. One of the main challenges for its practical use is understanding and controlling its shrinkage behavior. In this study, new experimental results for two alkali‐activated slag concrete mixes are presented under both sealed and unsealed conditions. The results show that basic shrinkage increases with increased sodium silicate ratio. Under unsealed conditions, the age to exposure to drying has a most significant impact on the final drying shrinkage. Finally, the mechanisms explaining shrinkage of such materials are discussed and thefib Model Code 2010 is extended for alkali‐activated slag concrete using the new experimental results. The extended model consists of four parameters influencing the final values and the speed of both basic shrinkage and drying shrinkage. It is extensively compared with experimental datasets from the literature and improves significantly predictions compared with the original models for both basic and drying shrinkage. This demonstrates clearly the feasibility to extend it for predicting shrinkage of alkali‐activated slag concrete.
Long noncoding RNA TDRG1 aggravates doxorubicin‐induced cardiomyopathy by binding with miR‐873‐5p to upregulate PRKAR2
Authors: Liu Yihang , Tan Linlin , Zhang Ming , Yang Chuang 
Published: May 2022

AbstractDoxorubicin‐induced cardiomyopathy (DCM) is a life‐threatening event. The long noncoding RNAs (lncRNAs) have been reported with close associations with DCM, which may provide novel insight into pathophysiological mechanisms of DCM. DCM rat model and cell models were established using doxorubicin. Echocardiography analyses were performed to assess cardiac function. We found that testis developmental‐related gene 1 (TDRG1) expression was upregulated in DCM rats and in doxorubicin‐treated human umbilical vein endothelial cells (HUVECs). TDRG1 knockdown enhanced cell viability, promoted tube formation, and inhibited apoptosis of doxorubicin‐treated HUVECs. Additionally, knockdown of TDRG1 alleviated cardiac injury in DCM rats. Mechanistically, miR‐873‐5p was identified to bind with TDRG1. In addition, protein kinase cAMP‐dependent type II regulatory subunit alpha (PRKAR2) was confirmed to bind with miR‐873‐5p as a target mRNA. MiR‐873‐5p negatively regulated PRKAR2 mRNA and protein levels. At last, rescue assays indicated that the overexpression of PRKAR2 restored the effect of TDRG1 knockdown on doxorubicin‐treated HUVEC angiogenesis and apoptosis. To conclude, TDRG1 aggravates DCM progression by binding with miR‐873‐5p to upregulate PRKAR2. This work suggested the potential of TDRG1 as a target for DCM treatment.
Antitumor activity of pachymic acid in cervical cancer through inducing endoplasmic reticulum stress, mitochondrial dysfunction, and activating the AMPK pathway
Authors: Yang Ting , Tian Sijuan , Wang Yaohui , Ji Jing , Zhao Juan 
Published: May 2022

AbstractPachymic acid has various pharmacological effects, including anti‐inflammatory, antioxidant, immunomodulatory, and antitumor. However, the role of pachymic acid in cervical cancer remains unclear. So, we investigated the effects of pachymic acid in cervical cancer and elucidated the underlying mechanisms. We treated HeLa cells and normal cervical epithelial cells (HUCECs) with pachymic acid (0, 10, 20, 40, 80, or 160 μM) for 72 h, and found the cell activity was decreased in cells treated with 160 μM pachymic acid for 48 h or 80 μM pachymic acid for 72 h, while HUCECs viability without effect. Next, we observed that endoplasmic reticulum (ER) related gene expression, mitochondrial membrane potential (MMP) changes, ATP depletion, reactive oxygen species (ROS) generation and apoptosis were increased. Moreover, we observed that cytochrome C (Cytc) expression was increased and apoptosis‐inducing factor (AIF) was decreased in the cytoplasm of pachymic acid‐treated HeLa cells. Tauroursodeoxycholic acid (TUDCA) of ER stress inhibitor reversed the effects of pachymic acid on HeLa cells. Phosphorylation of AMPK and acetyl‐CoA carboxylase (ACC) of the AMPK pathway key protein was upregulated in pachymic acid‐induced HeLa cells. Finally, we subcutaneously implanted HeLa cells into female nude mice and treated them with pachymic acid (50 mg/kg) for 3 weeks (5 days/week), and observed in pachymic acid induced xenograft mice, tumor growth was suppressed, cell apoptosis, ER‐related gene expression, and ROS levels in tumor tissues were increased. Therefore, these findings demonstrated that pachymic acid plays an anti‐tumor activity in cervical cancer through inducing ER stress, mitochondrial dysfunction, and activating the AMPK pathway.