bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relevancy of Serum SuPAR, PAI-1, MMP-9 Level, And Prognosis Of Metastatic Colorectal Cancer During Diagnosis
Authors: Kalender Mehmet Eren , Demir Leyla , Oflazoğlu Utku , Küçükzeybek Yüksel , Salman Tarık , Varol Umut , Yıldız Yaşar , Güc Zeynep Sevgen , Taşkaynatan Halil , Alacacıoğlu Ahmet 
Published: June 2022

Abstract
Introduction:
Serum suPAR, PAI-1, and MMP-9 biomarkers have been associated with the progression of the disease in many cancers, including the CRC.
Objectives
It aimed to determine the relation of serum suPAR, PAI-1, and MMP-9 levels with the prognosis of the disease in patients with mCRC.
Materials and Methods
Nonmetastatic CRC patients who had not yet been treated with the oncology polyclinic in İKCU and blood samples were taken from the patients with metastatic CRC before and after treatment, and the obtained serum was preserved. PAI-1, suPAR, and MMP-9 levels were studied by ELISA. The results were used to establish the relation with prognosis.
Results
When the metastatic group and non-metastatic group were compared before treatment for biomarkers; PAI-1 (p-value: 0.030), suPAR (p-value: 0.009) and MMP-9 (p-value: 0.003) were found to be highly significant. PAI-1 (p-value: 0.003), suPAR (p-value: 0.007), and MMP-9 (p-value: 0.001) in the pretreatment metastatic group and the control group after the treatment were statistically significant. ROC was performed and cut-off values were determined as (pai: 71.4 ng / ml; supar: 1.97 ng / ml; mmp: 812.5 ng / ml). PFS and OS were evaluated to the cut-offs of markers using the Kaplan-Meier method. Cut off values were significant in terms of PFS (pai p-value, 0.008; supar p-value 0.019, mmp p-value 0.017) and OS (pai p-value, 0.03; supar p-value 0.059, mmp p-value 0.081).
Conclusion
Serum PAI-1, suPAR, and MMP-9 levels reveal the prognosis of patients with metastatic CRC
Dynamic analysis and experiment of wheeled mobile robot system with a flexible manipulator based on MS-DT-TMM
Authors: Chen Wei , Tong Jiaqi , Du Changquan 
Published: June 2022

Abstract
In recent years, robots based on fixed base cannot meet the increasingly prominent application needs such as in service and industry. Compared with traditional robots, the mobile flexible manipulator has wider workspace and more flexible characteristics. Therefore, it is gradually becoming the focus of attention. In this paper, the dynamic modeling, analysis and experimental research are investigated by employed MS-DT-TMM (Discrete Time Transfer Matrix Method for Multibody System) for a wheeled mobile robot system with a flexible manipulator. Firstly, the discrete-time transfer matrix method and its solution process are overviewed. Then, the 3-joint flexible manipulator mounted on the wheeled mobile robot is divided into 8 components. According to the idea of modeling method, the system dynamic model is integrated by using the transfer matrix equations of 8 components. Moreover, based on the existing experimental conditions, the dynamic simulation and experimental research of single degree of freedom planar flexible manipulator are carried out. The data results validate the correctness and feasibility of the proposed model. Finally, the numerical simulation research of whole mobile flexible robot is completed. The effectiveness of the model is verified by analyzing the data of wheel forces, links and joints motion, the displacements of the end effector and so on. Further, the comparison of the end errors of the mobile robot carrying rigid link and flexible link in the simulation results demonstrates the necessity of modeling the flexible component in the system.
Health behaviours the month prior to COVID-19 infection and the development of self-reported long COVID and specific long COVID symptoms: A longitudinal analysis of 1,811 UK adults
Authors: Paul Elise , Fancourt Daisy 
Published: June 2022

Abstract
BackgroundThe aim of this study was to examine whether specific health behaviours in the month preceding infection with COVID-19 act as upstream risk factors long COVID as well and three specific long COVID symptoms.Methods1,811 UK adults from the UCL COVID-19 Social Study and who had previously been infected with COVID-19 were analysed. Health behaviours in the month before infection were weekly exercise frequency, days of fresh air per week, sleep quality, smoking, consuming more than the number of recommended alcoholic drinks per week (>14), and the number of mental health care behaviours (e.g., online mental health programme). Logistic regressions controlling for covariates (e.g., COVID-19 infection severity and pre-existing health conditions) examined the impact of health behaviours on long COVID and three long COVID symptoms (difficulty with mobility, cognition, and self-care).Results In the month before infection with COVID-19, poor quality sleep increased the odds of long COVID (odds ratio [OR]: 3.53; (95% confidence interval [CI]: 2.01 to 6.21), as did average quality sleep (OR: 2.44; 95% CI: 1.44 to 4.12). Having smoked (OR: 8.39; 95% CI: 1.86 to 37.91) increased and meeting recommended weekly physical activity guidelines (3+ hours) (OR: 0.05; 95% CI: 0.01 to 0.39) reduced the likelihood of difficulty with self-care (e.g., washing all over or dressing) amongst those with long COVID. Conclusions Results point to the importance of sleep quality for long COVID, potentially helping to explain previously demonstrated links between stress and long COVID. Results also suggest that exercise and smoking may be modifiable risk factors for preventing the development of difficulty with self-care.
Research on the crystallization blockage law and blockage classification of mixed solution in dolomite tunnel drainage system
Authors: Rao Junying , Peng Xing , Tao Yonghu 
Published: June 2022

Abstract
Tunnel seepage is one of the most common pathological disasters in tunnel engineering. Drainage pipes (ditch) caused by crystallization blockage emerge in an endless stream, especially in tunnels built in soluble rock areas such as dolomite and limestone, which it is one of the causes of water leakage, so it is of theoretical and practical significance to explore the factors and mechanisms of crystallization in the drainage system of dolomite tunnels. To study the crystallization blockage law of mixed solution in the drainage system of dolomite tunnels, based on the on-site geological survey, water quality inspection, and indoor model test, the crystallization blockage law of mixed solution in the drainage system was explored, and the classification of crystallization blockage was proposed based on the test. The test shows that: First, the crystallization blockage of the water outlet of the vertical drainage pipe (longitudinal pipe) and the horizontal drainage pipe (horizontal pipe) is more serious, while the crystallization blockage of the annular drainage pipe (ring pipe) is less. Second, the Cl–K+-Na+ ion coupling concentration will affect the crystallization, and the pipe crystallization is also positively correlated with the CO32--SO42--Ca2+-Mg2+-Al3+ ion coupling concentration. The higher the concentration, the more crystallization, and the crystal growth law The performance is fast and then slow. Third, the evaluation of the blockage degree of the vertical tube, the horizontal tube, and the ring tube shows that the amount of crystallization per linear meter of the horizontal tube is more, and the degree of crystal blockage is higher, while the degree of crystallization of the vertical tube is between the horizontal tube and the ring tube. Fourth, after preliminary construction of the classification model and classification theory of crystallization blockage in drainage pipes, indexes such as classification coefficient l, blockage height H, and surrounding rock pressure σ are calculated. Based on the quantitative indexes, the classification of crystallization blockage degree is proposed. The crystal blockage of the tunnel drainage pipe is divided into four grades: complete blockage, severe blockage, moderate blockage, and mild blockage.
Erratic and Blood Vessel-Guided Dispersion of Astrocyte Progenitors in the Cerebral Cortex
Authors: Tabata Hidenori , Sasaki Megumi , Agetsuma Masakazu , Sano Hitomi , Hirota Yuki , Hayashi Kanehiro , Honda Takao , Nishikawa Masashi , Inaguma Yutaka , Ito Hidenori , Takebayashi Hirohide , Ema Masatsugu , Ikenaka Kazuhiro , Nabekura Junichi , Nagata Koh-ichi , Nakajima Kazunori 
Published: June 2022

Abstract
Astrocytes are one of the most abundant cell types in the mammalian brain. They play essential roles in synapse formation, maturation, and elimination. However, how astrocytes migrate into the gray matter to accomplish these processes is poorly understood. Here, we show that, by combinational analyses of in vitro and in vivo time-lapse observations and lineage traces, astrocyte progenitors move rapidly and irregularly within the developing cortex, which we call erratic migration. Astrocyte progenitors also adopt blood vessel-guided migration. These highly motile progenitors are generated in the restricted prenatal stages and differentiate into protoplasmic astrocytes in the gray matter, whereas postnatally generated progenitors do not move extensively and differentiate into fibrous astrocytes in the white matter. We found Cxcr4/7, and integrin β1 regulate the blood vessel-guided migration, and their functional blocking disrupts their positioning. This study provides fundamental principles of astrocyte development and can contribute to understanding the pathogenesis caused by their defects.
Long-term Benefits in Emergency Admissions, Hospitalization and Metabolic Control of an Integrated Continuous Glucose Monitoring and Insulin Pump System in a Cohort of Diabetic Patients
Authors: O´Meara Miguel Augusto , Mateus Juan Camilo , Uribe Andrea 
Published: June 2022

Abstract
Background

There is evidence in the literature that the use of sensor-augmented insulin pumps in patients with type 1 diabetes improves metabolic control. However, there is no long-term information on clinical outcomes such as hospitalization or admission to the emergency room.
Our paper describes the outcomes of metabolic control, incidence of hospitalizations and emergency room visits in a Colombian population using this technology.

Methods

A retrospective cohort study was carried out in patients with diabetes being treated with an intensive insulin regimen at a specialized diabetes treatment center in Bogotá, Colombia, who required sensor-augmented insulin pumps due to poor metabolic control. Glycated hemoglobin, severe hypoglycemic episodes, non-severe hypoglycemic episodes, perception of hypoglycemia, and the incidence of emergency room visits and hospitalizations before and after treatment were evaluated.

Results

Sixty-four patients with a median age of 36 years (interquartile range 2746) were included in the study. We found better long-term management in terms of glycated hemoglobin (8.35% vs. 7%), non-severe hypoglycemic episodes (95.9% vs. 87.7%), emergency room visits (57.5% to 6.45%) and hospitalization (50% vs. 13.79%).

Conclusions

The use of sensor-augmented insulin pumps coupled with a strict follow up program for patients with type 1 diabetes leads to a significant and sustained reduction in glycated hemoglobin and hypoglycemic episodes, as well as in the rate of emergency room visits and hospitalizations. These results incentivize the adoption of this technology in patients who do not achieve metabolic control with optimal management of type 1 diabetes.
Risk factors for postoperative cognitive dysfunction in elderly patients undergoing surgery for oral malignancies
Authors: Wu Yujia , Yu Cong , Gao Feng 
Published: June 2022

Abstract
We aimed to analyze postoperative cognitive dysfunction (POCD) incidence and risk factors in elderly adults who underwent surgery for oral malignancies. A total of 112 elderly patients (aged ≥ 55 years) were selected for extended resection of descending oral malignancies at our institution from December 2020 to December 2021. Participants were cognitively evaluated using the neuropsychological test scale 1 day preoperatively and 7 days postoperatively to determine whether they had developed POCD. Based on whether POCD occurred 7 days postoperatively, patients were classified into the POCD and non-POCD groups. Logistic regression was applied to perioperative factors to analyze the risk factors for POCD onset. Seven days postoperatively, there were 37 (33.1%) POCD morbidities. Multiple factor logistic regression analysis revealed that venerable age (odds ratio [OR]=1.269, 95% confidence interval [CI] 1.056−1.525, P<0.05), low education levels (OR=0.792, 95%CI 0.644−0.974, P<0.05), hypertension (OR=4.153, 95%CI 1.335−12.732, P<0.05), dyssomnia (OR=1.272, 95%CI 1.001−1.617, P<0.05), prolonged anaesthesia (OR=1.009, 95%CI 1.001−1.018, P<0.05), and intraoperative hypotension (OR=5.512, 95%CI 1.240−24.506, P<0.05) increased the POCD risk in elderly patients who underwent surgery for oral malignancies. Venerable age, low knowledge reserve, hypertension, dyssomnia, prolonged anaesthesia, and intraoperative hypotension are independent risk factors for POCD in elderly patients with oral malignancies.
Network-specific metabolic and hemodynamic effects elicited by non-invasive brain stimulation
Authors: Eldaief Mark , McMains Stephanie , Izquierdo-Garcia David , Braga Rodrigo 
Published: June 2022

Abstract
Repetitive transcranial magnetic stimulation (TMS), when applied to dorsolateral prefrontal cortex (dlPFC), is an effective treatment for depression. Therapeutic effects are believed to arise from propagation of dlPFC stimulation effects across distributed corticolimbic networks. However, the mechanisms of the local and distributed effects of TMS are unresolved, and studies have yielded variable results. One possible explanation for this variability is that dlPFC contains representations of different, closely juxtaposed, large-scale networks. As such, TMS may exert different effects depending on the network being stimulated. If true, targeting networks non-specifically may account for the large number of TMS treatment failures in depression. To test this, we used TMS to stimulate two nearby dlPFC targets in the same individuals. The two targets were functionally embedded in distinct anticorrelated networks: the default network and the salience network. Local and distributed effects of TMS were measured with combined whole-brain 18fluorodeoxyglucose positron emission tomography (FDG-PET) and functional magnetic resonance imaging (fMRI). Identical TMS patterns caused opposing effects on local glucose metabolism, with metabolism increasing at the salience target and decreasing at the default target. At the distributed level, both conditions reduced FC anticorrelation between the default and salience networks. However, FC effects were dramatically larger following default TMS. Metabolic and hemodynamic effects were also linked: across subjects, the magnitude of local metabolic changes correlated with the degree of FC changes. These results suggest that TMS effects upon dlPFC are network-specific. They also invoke putative mechanisms of TMS in depression, specifically the de-coupling of large-scale networks.
A Qualitative Study of Barriers to Care-Seeking for Diabetic Foot Ulceration Across Multiple Levels of the Healthcare System
Authors: Tan Tze-Woei , Crocker Rebecca M. , Palmer Kelly N.B. , Gomez Chris , Armstrong David G. , Marrero David G. 
Published: June 2022

Abstract
IntroductionThe mechanisms for the observed disparities in diabetes-related amputation are poorly understood and could be related to access for diabetic foot ulceration (DFU) care. This qualitative study aimed to understand patients’ personal experiences navigating the healthcare system and the barriers they faced. MethodsFifteen semi-structured interviews were conducted over the phone between June 2020 to February 2021. Participants with DFUs were recruited from a tertiary referral center in Southern Arizona. The interviews were audio-recorded and analyzed according to the NIMHD Research Framework, focusing on the health care system domain. ResultsAmong the 15 participants included in the study, the mean age was 52.4 years (67% male), 10 participants were from minority racial groups, and 11 were Medicaid or Indian Health Service beneficiaries. Participants frequently reported barriers at various levels of the healthcare system. On the individual level, themes that arose included health literacy and inadequate insurance coverage resulting in financial strain. On the interpersonal level, participants complained of fragmented relationships with providers and experienced challenges in making follow-up appointments. On the community level, participants reported struggles with medical equipment. On the societal level, participants also noted insufficient preventative foot care and education before DFU onset, and many respondents experienced initial misdiagnoses and delays in receiving care.ConclusionsPatients with DFUs face significant barriers in accessing medical care at many levels in the healthcare system and beyond. These data highlight opportunities to address the effects of diabetic foot complications and the inequitable burden of inadequately managed diabetic foot care.
A Comparative Study of Freehand Technique and A Novel Laser Guiding Navigation in Distal Locking of Femoral Intramedullary Nails
Authors: Gao Hua , Liu Zhenyu , Bai Xiaodong , Xu Guoqiang , Chen Wentao , Ma Ji , Wang Yijun , Wang Jiatian , Wang Gang , Wang Baojun 
Published: June 2022

Abstract
Background
Intramedullary nail(IMN) is one of the key essential minimally invasive "weapons" in orthopaedic trauma, while the distal locking is still challenging for surgeons. Although there are various inventions and technologies to improve the locking procedure, there are still problems such as inaccurate positioning, excessive radiation exposure, low first success rate and long learning curve. Therefore, a new laser guiding navigation device was designed and compared with the traditional freehand (FH) technique in the distal locking of femoral IMN.
Methods
The Self-designed laser navigation device (laser group) and freehand technique (FH group) were used in the distal locking of the IMNs in the patients with femoral diaphyseal fracture. All operations were performed by two surgeons of the same level. The differences between the two groups were compared in terms of radiation exposure time, operative time, first success rate, blood loss, visual analogue score(VAS), Harris score and healing time.
Results
32 patients were enrolled and16 patients in each group. The results showed that the laser group was better than the FH group in terms of distal locking time (10(9/11)vs19.5(17.25/21)minutes, Z = 4.83, P < 0.001), distal locking radiation exposure time (46.5(41.25/51.75)vs105(88.25/140) seconds, Z = 4.807, P < 0.001), first success rate (30/32 vs 20/32, χ2 = 9.143, P = 0.002) and blood loss(60(50–100) vs 150(105-192.5) mL, Z = 3.610, P = 0.0003). There was no difference in Harris score, VAS score, or fracture healing time between the two groups.
Conclusion
Compared with the FH technique, the novel laser guiding navigation device for distal locking of femoral IMN has the advantages of shorter operative time, less radiation exposure and higher first success rate.
Formation of FeS Tribofilm from Unsymmetrical Disulfides as Effective Extreme Pressure and Antiwear Additives
Authors: Ong Chiu Ling , Lim Shi Teng , Lai Yew Chong , Chong Kim Fong , Khaligh Nader Ghaffari , Heidelberg Thorsten , Juan Joon Ching 
Published: June 2022

Abstract
Sulfur-based additives have excellent extreme pressure (EP) performance. However, a high amount of sulfur causes metal corrosion. The non-corrosive and ashless organo-disulfides have been synthesized via Bunte salt method. The unsymmetrical dodecyl octyl disulfide (DDODS) with good oil-solubility provides better EP and anti-wear (AW) properties. The DDODS shows outstanding EP value (1961 N) and small WSA (9 mm²) in naphthenic base oil (NBO), respectively. This performance is superior compared to symmetrical didodecyl disulfide (DDDS). The outstanding performance of DDODS is due to the good solubility in NBO and the formation of a sulfur film on the metal surface. The formation of iron sulfide (FeS) under EP conditions provides excellent tribofilm compared to iron (III) oxide (Fe2O3) and iron sulfate (FeSO4).
Convolutional Neural Network (CNN) with Randomized Pooling
Authors: Imran Hafiz , Aamir Khalid , Ilyas Muhammad 
Published: June 2022

Abstract
Convolutional Neural Network (CNN) is a deep learning approach to solve complex problems, and it has been widely used in image processing for image classification, object identification, semantic segmentation etc. It has overcome the constraint of traditional machine learning approaches. There has been a lot of effort done to improve the accuracy of CNN in many application areas, but there has been a lesser amount of work done to reduce the computational complexity of this model. There is a need to improve CNN's complexity problem. Here we have introduced randomized pooling (RANDpool) to CNN. Randomized pooling has reduced the computational complexity cost of CNN. We used MNIST dataset to demonstrate CNN with randomized pooling. This paper used randomization technique to reduce the dimensions of image instead of max, min or average pooling that have very extensive computations.
The emergence of Human Metapneumovirus G gene duplication in hospitalized patients with respiratory tract infection, India, 2016 ‐2018.
Authors: Parida Preetiparna , N SUDHEESH , R Sanjay E , Jagadesh Anitha , Marate Srilatha , Arunkumar Govindakaranavar 
Published: June 2022

Abstract
Background: Human metapneumovirus (HMPV) belongs to the family Pneumoviridae. It is one of the emerging respiratory viruses causing both upper and lower respiratory tract illnesses. HMPV has two genotypes: A and B. These genotypes are classified into lineage A1, A2, B1 and B2. Lineage-A2 is further classified as A2a, A2b and A2c. Similarly, B2 is classified as B2a and B2b. Studies have shown the circulation of A2b, B1 and B2 lineages in India. However, a limited amount of data is available on the current circulating genotypes of HMPV in India. Methods: Throat swab samples positive for HMPV by real-time PCR, archived at Manipal Institute of Virology as a part of a hospital-based acute febrile illness surveillance study, were used from April 2016 to August 2018 by purposive sampling method. We performed the conventional reverse transcriptase-polymerase chain reaction for twenty samples targeting the G gene and then subjected them to sequencing. Phylogenetic analysis was done using MEGA X software by the Maximum Likelihood method. Results: All the twenty sequences belonged to the A2c subgroup. Phylogenetic analysis showed that strains from the study have genetic relation with circulating strains in Japan, China and Croatia. Seven out of the twenty sequences showed 180 nucleotide duplication, and eleven sequences showed 111 nucleotide duplication. Two sequences did not show any duplications. Conclusion: In the current study, we report that A2c is the sub-lineage in India from April 2016 to August 2018. This study is the first retrospective study reporting the circulation of the A2c sub-lineage among adults in India with 180 and 111 nucleotide duplications in the G gene of human metapneumovirus.