bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with physical activity reduction in Swedish older adults during the first COVID-19 outbreak: a longitudinal population-based study
Authors: Sjöberg Linnea , Triolo Federico , Saadeh Marguerita , Dekhtyar Serhiy , Calderón-Larrañaga Amaia , Welmer Anna-Karin 
Published: April 2022

Abstract
Background
Physical activity (PA) decreased during the COVID-19 pandemic, especially among older adults, potentially leading to adverse consequences for their health. However, factors associated with reductions of PA during the pandemic have not been examined in a population-based sample of older adults. Thus, the aim of this study was to explore the association of pre-pandemic physical, mental, social and lifestyle factors with reductions in PA in older adults during the first wave of COVID-19, and whether the associations differed by age and sex.

Methods
A population-based sample of 624 participants aged 65-99 years were identified from the Swedish National study on Aging and Care in Kungsholmen (SNAC-K) COVID19 Study. Information on pre-pandemic factors was collected through clinical examinations, interviews, and self-administered questionnaires in 2016-2019. Changes in light and intense PA during the first wave of the pandemic (May-September 2020) were self-reported. Data were analyzed using multiple logistic regression models, stratified by age (<70 vs. >80 years) and sex.

Results
There was an association between pre-pandemic levels of higher depressive symptom burden (Odds Ratio (OR): 2.6, 95% Confidence Interval (CI): 1.1-6.4, <70 years), and impaired balance (OR: 1.7, 95% CI: 1.0-2.8, >80 years old) with reductions in light-intensity PA. Furthermore, the presence of musculoskeletal disease (OR: 1.8, 95% CI: 1.1-2.9, <70 years; OR: 2.3, 95% CI: 1.2-4.4, men), moderate/high levels of neuroticism (OR: 1.6, 95% CI: 1.0-2.6, <70 years; OR: 2.2, 95% CI: 1.3-3.5, women), and poor levels of social support (OR: 2.2, 95% CI: 1.2-4.3, >80 years) were related to reductions in higher-intensity PA. Those who were current smokers (OR: 0.3, 95% CI: 0.1-0.8, <70 years; OR: 0.2, 95% CI: 0.06-0.7, women), or had impaired balance (OR: 0.4, 95% CI: 0.2-0.8, >80 years) were less likely to reduce their levels of higher-intensity PA.

Conclusions
For future pandemics or waves of COVID-19, development of strategies is warranted for older individuals with psychiatric- or physical illness/dysfunction, as well as those with poor social support to counteract reductions in physical activities.
The impact of direct challenges to student endorsement of teleological reasoning on understanding and acceptance of natural selection: an exploratory study
Authors: Wingert Jason R. , Bassett Gennie M. , Terry Caitlin E. , Lee Jimin 
Published: April 2022

Abstract
Background
Teleological reasoning is a cognitive bias purported to disrupt student ability to understand natural selection. Few studies have described pedagogical efforts to decrease student endorsement of teleological reasoning and measure the effects of this attenuation on the understanding and acceptance of evolution. This exploratory study examined the influence of explicit instructional activities directly challenging student endorsement of teleological explanations for evolutionary adaptations on their learning of natural selection over a semester-long undergraduate course in evolutionary medicine. In a convergent mixed methods design this study combined pre- and post-semester survey data (N = 83) on understanding natural selection, student endorsement of teleological reasoning, and acceptance of evolution, with thematic analysis of student reflective writing on their understanding and acceptance of natural selection and teleological reasoning.

Results
Student endorsement of teleological reasoning decreased and understanding and acceptance of natural selection increased during a course on human evolution with teleological intervention (p ≤ 0.0001), compared to a control course. Endorsement of teleological reasoning was predictive of understanding of natural selection prior to the semester. Thematic analysis revealed that prior to the course students were largely unaware of the concept of teleological reasoning and their own tendency to think about evolution in a purpose-directed way, but perceived attenuation of their own teleological reasoning by the end of the semester.

Conclusions
This exploratory study provides initial evidence that class activities to directly challenge student endorsement of unwarranted design teleological reasoning reduces the level and effects of teleological reasoning in an evolution course. Students were unaware of their high levels of endorsement of teleological reasoning upon entrance into the undergraduate human evolution course, which is consequential because teleological reasoning is a predicter of natural selection understanding. As a result of developed anti-teleological pedagogy, students had decreased unwarranted teleological reasoning and increased acceptance and understanding of natural selection over the course of the semester. The data presented show that students are receptive to explicit instructional challenges to their teleological reasoning and that attenuation of this bias is associated with gains in natural selection understanding and acceptance.
Configuring user information by considering trust threatening factors associated with automated vehicles
Authors: Yun Hanna , Yang Ji Hyun 
Published: March 2022

Abstract
Background
The accelerated development of automated driving technology has raised the expectation that commercially available automated vehicles will be increasingly become ubiquitous. It has been claimed that automated vehicles are safer than conventional manual vehicles, leading to the expectation of fewer accidents. However, people expect not only better but also near-perfect machines. Given that accidents involving automated vehicle do occur and are highlighted by the media, negative reactions toward automated vehicles have increased. For this reason, it is critical to research human–machine interaction to develop suitable levels of trust between human users and newly introduced automated vehicle systems.

Method
We start this study by defining user distrust toward automated vehicles in terms of four types of trustthreatening factors (TTFs) along with trust-threatening situations. Next, with 30 volunteer participants, we conduct a survey and a humanin-the-loop experiment involving riding in a simulated automated vehicle and experiencing 21 distrust scenarios.

Result
In terms of the information configuration type suitable for alleviating the TTFs, the participants preferred to receive information on external object recognition for all TTFs in general with an average necessity level score of 24.2, which was 8.0 points higher on average than the scores of the other information configuration types. The haptic modality-based method was the least preferred compared to the other information configuration methods, namely visual and auditory.

Conclusion
In this study, we focused on participants’ subjective responses and complementary quantitative studies, and the results of these studies put together are expected to serve as a foundation for designing a user interface that can induce trust toward automated vehicle among users.
Olfactory function and discrimination ability in the elderly: a pilot study
Authors: Uchida Sae , Shimada Chiho , Sakuma Naoko , Kagitani Fusako , Kan Akiko , Awata Shuichi 
Published: April 2022

AbstractWe recently reported that subjects with a higher olfactory identification threshold for rose odor declined more in attentional ability in the elderly. This study focuses on discrimination ability and olfactory identification threshold in twelve elderly subjects living in a community (age: 80.9 ± 1.6). Olfactory function was assessed by the rose odor identification threshold. We assessed the discrimination ability by distinguishing 5 similar odor pairs. Our results showed that the subjects with a higher olfactory identification threshold (≥ 5) declined more in discrimination ability (14% ± 14%, p = 0.03) compared to those with a lower threshold (≤ 4) (averaged value set at 100%). As discrimination ability is related to the basal forebrain cholinergic system, our results suggest that olfactory impairment links to the decline in cognitive function relating the cholinergic system.
Chromatin-remodeling factor CHR721 with non-canonical PIP-box interacts with OsPCNA in Rice
Authors: Zhang Yushun , Chen Qiong , Zhu Guanlin , Zhang Dechun , Liang Weihong 
Published: April 2022

Abstract
Background
Proliferating cell nuclear antigen (PCNA) is one of the key factors for the DNA replication process and DNA damage repair. Most proteins interacting with PCNA have a common binding motif: PCNA interacting protein box (PIP box). However, some proteins with non-canonical PIP-box have also been reported to be the key factors that interacted with PCNA.

Results
Here we discovered the C terminal of a chromatin-remodeling factor CHR721 with non-canonical PIP-box was essential for interacting with OsPCNA in rice. Both OsPCNA and CHR721 were localized in the nuclei and function in response to DNA damages.

Conclusions
Based on the results and previous work, we proposed a working model that CHR721 with non-canonical PIP-box interacted with OsPCNA and both of them probably participate in the DNA damage repair process.
Low irrigation water minimizes the nitrate nitrogen losses without compromising the soil fertility, enzymatic activities and maize growth
Authors: Muhammad Ihsan , Lv Ju Zhi , Yang Li , Ahmad Shakeel , Farooq Saqib , Zeeshan Muhammad , Zhou Xun Bo 
Published: April 2022

AbstractNitrate nitrogen (NO3−_N) leaching increased with nitrogen (N) fertilization under high water supply to the field negatively affected the maize growth and performance. This study aimed to understand the mechanisms of NO3−_N leaching on a biochemical basis and its relationship with plant performance with 5 different doses (0, 200, 250, 300, 350 kg N ha− 1) of N fertilizers under low (60%; LW) and high (80%; HW) water holding capacity. Soil and plant enzymes were observed at different growth stages (V9, R1, R3, and R6) of the maize, whereas the leachates were collected at 10-days intervals from the sowing date. The LW had 10.15% lower NO3−_N leachate than HW, with correspondence increases in grain yield (25.57%), shoot (17.57%) and root (28.67%) dry matter. Irrespective of the irrigation water, RubisCo, glutamine synthase (GS), nitrate reductase (NR), nitrite reductase (NiR), and glutamate synthase (GOGAT) activities increased with increasing N fertilizer up to the V9 growth stage and decreased with approaching the maturity stage (R6) in maize. In HW irrigation, soil total N, GOGAT, soil nitrate (NO3−_N), leached nitrate (LNO3−_N), root N (RN), leaf N (LN) were positively correlated with N factors suggesting the higher losses of N through leaching (11.3%) compared to LW irrigation. However, the malondialdehyde (MDA), hydrogen peroxide (H2O2), superoxide (O2−), and proline were negatively correlated with the other enzymatic activities both under LW and HW irrigation. Thus, minimizing the NO3−_N leaching is possibly correlated with the LW and N300 combination without compromising the yield benefit and improving enzyme activities.
Impact of a dementia-friendly program on detection and management of patients with cognitive impairment and delirium in acute-care hospital units: a controlled clinical trial design
Authors: Weldingh NM , Mellingsæter MR , Hegna BW , Benth J Saltyte , Einvik G , Juliebø V , Thommessen B , Kirkevold M 
Published: March 2022

Abstract
Background
Frail older persons with cognitive impairment (CI) are at special risk of experiencing delirium during acute hospitalisation. The purpose of this study was to investigate whether a dementia-friendly hospital program contributes to improved detection and management of patients with CI and risk of delirium at an acute-care hospital in Norway. Furthermore, we aimed to explore whether the program affected the detection of delirium, pharmacological treatment, 30-day re-hospitalisation, 30-day mortality and institutionalisation afterwards.

Methods
This study was part of a larger quality improvement project aiming at developing and implementing a new program for early screening and management of patients with CI. This study, evaluating the program are designed as a controlled clinical trial with a historical control group. It was conducted at two different medical wards at a large acute-care hospital in Norway from September 2018 to December 2019. A total of 423 acute hospitalised patients 75 years of age or older were included in the study. Delirium screening and cognitive tests were recorded by research staff with the 4 ‘A’s Test (4AT) and the Confusion Assessment Measure (CAM), while demographic and medical information was recorded from the electronic medical records (EMR).

Results
Implementation of the dementia-friendly hospital program did not show any significant changes in the identification of patients with CI. However, the share of patients screened with 4AT within 24 h increased from 0% to 35.5% (P < .001). The proportion of the patients with CI identified by the clinical staff, who received measures to promote “dementia-friendly” care and reduce the risk for delirium increased by 32.2% (P < .001), compared to the control group. Furthermore, the number of patients with CI who were prescribed antipsychotic, hypnotic or sedative medications was reduced by 24.5% (P < .001). There were no differences in delirium detection, 30-day readmission or 30-day mortality.

Conclusions
A model for early screening and multifactorial non-pharmacological interventions for patients with CI and delirium may improve management of this patient group, and reduce prescriptions of antipsychotic, hypnotic and sedative medications. The implementation in clinical practice of early screening using quality improvement methodology deserves attention.

Trial registration
The protocol of this study was retrospectively registered in the ClinicalTrials.gov Protocol Registration and Results System with the registration number: NCT04737733 and date of registration: 03/02/2021.
Reliability and validity of the fall risk self-assessment scale for community-dwelling older people in China: a pilot study
Authors: Wang Zhizhuo , Rong Yuetong , Gu Li , Yang Yanyan , Du Xinmin , Zhou Mouwang 
Published: April 2022

Abstract
Background
Falls are a common and serious public health issue among older adults, contributing to the loss of independence, psychological distress, and incapability to engage in meaningful occupations, etc. However, there is a lack of abundant information about the fall risk self-evaluation scale for community-dwelling older people. Therefore, this study aimed to evaluate the preliminary reliability and validity of the fall risk self-assessment scale (FRSAS) among community-dwelling older adults.

Methods
A cross-sectional study was conducted. A total of 230 individuals aged 65 years and over were recruited by a convenience sampling between October and December 2020 from three communities in Haidian district, Beijing. Eligible participants were required to fill in the general condition questionnaire and the fall risk self-assessment scale. The reliability and validity were analyzed by using SPSS 20.0.

Results
Two hundred twenty-two participants completed the assessment as required (the completion rate was 96.52%). The most items of FRSAS were understood by older adults, which was completed in 10 min. Cronbach’s α and intraclass correlation coefficient ICC (2,1) of the scale were 0.757 and 0.967 respectively, suggesting good internal consistency and test-retest reliability. Exploratory factor analysis yielded 14 factors that explained 61.744% of the variance. Five items failed to be categorized into any factors because the factor loading of these items was less than 0.4. A future large-sample study needs to be conducted to explore its construct validity. The total scores and dimensional scores except for C-dimension showed significant differences between participants who had experienced a fall in the previous 6 months and those who had not (P < 0.05), indicating good discriminant validity.

Conclusions
The fall risk self-assessment scale including 41 items demonstrated relatively high feasibility as well as satisfactory results in the internal consistency, test-retest reliability, and discriminant validity.

Trial registration
Registration number: ChiCTR2000038856; Date of registration: 7 Oct 2020.
Distribution of FFRCT in single obstructive coronary stenosis and predictors for major adverse cardiac events: a propensity score matching study
Authors: Jin Xianglan , Jin Xiangyu , Wu Xiaoyun , Chen Luguang , Wang Tiegong , Zang Wangfu 
Published: March 2022

Abstract
Background
Fractional flow reserve derived from computed tomography (FFRCT) has been demonstrated to improve identification of lesion-specific ischemia significantly compared with coronary computed tomography angiography (CCTA). It remains unclear whether the distribution of FFRCT values in obstructive stenosis between patients who received percutaneous coronary intervention (PCI) or not in routine clinical practice, as well as its association with clinical outcome. This study aims to reveal the distribution of FFRCT value in patients with single obstructive coronary artery stenosis and explored the independent factors for predicting major adverse cardiac events (MACE).

Methods
This was a retrospective study of adults with non-ST-segment elevation acute coronary syndrome undergoing FFRCT assessment by using CCTA data from January 1, 2016 to December 31, 2020. Propensity score matching (PSM) method was used to account for patient selection bias. The risk factors for predicting MACE were evaluated by a Cox proportional hazards regression analysis.

Results
Overall, 655 patients with single obstructive (≥ 50%) stenosis shown on CCTA were enrolled and divided into PCI group (279 cases) and conservative group (376 cases) according to treatment strategy. The PSM cohort analysis demonstrated that the difference in history of unstable angina, Canadian Cardiovascular Society Class (CCSC) and FFRCT between PCI group (188 cases) and conservative group (315 cases) was statistically significant, with all P values < 0.05, while the median follow-up time between them was not statistically significant (24 months vs. 22.5 months, P = 0.912). The incidence of MACE in PCI group and conservative group were 14.9% (28/188) and 23.5% (74/315) respectively, P = 0.020. Multivariate analysis of Cox proportional hazards regression revealed that history of unstable angina (adjusted odds ratio (adjOR), 3.165; 95% confidence interval (CI), 2.087–4.800; P < 0.001), FFRCT ≤ 0.8 (OR, 1.632;95% CI 1.095–2.431; P = 0.016), and PCI therapy (OR 0.481; 95% CI 0.305–0.758) were the independent factors for MACE.

Conclusions
History of unstable angina and FFRCT value of ≤ 0.8 were the independent risk factors for MACE, while PCI therapy was the independent protective factor for MACE.
Coping with Covid-19: stress, control and coping among pregnant women in Ireland during the Covid-19 pandemic
Authors: Crowe Sarah , Sarma Kiran 
Published: April 2022

Abstract
Background
The aim of the current study is to investigate the relationship between perceived control, coping and psychological distress among pregnant women in Ireland during the Covid-19 pandemic. It is hypothesised that lower levels of perceived control, greater use of avoidant coping and greater Covid-19 related pregnancy concern will be associated with psychological distress. In addition, it is hypothesised that the relationship between Covid-19 related pregnancy concern and psychological distress will be moderated by perceived control and avoidant coping.

Method
The study is cross-sectional, utilizing an online questionnaire, which was completed by 761 women in January 2021. The questionnaire includes measures of perceived control, coping style, perceived stress, anxiety and depression.

Results
Correlation analyses found that lower levels of perceived control were associated with higher levels of avoidant coping and psychological distress. There was also a significant positive relationship between avoidant coping and psychological distress. Using multiple regression, perceived control, avoidant coping and Covid-19 related pregnancy concern were found to predict 51% of the variance in psychological distress. However, in the moderation analysis, perceived control and avoidant coping were not found to moderate the relationship between Covid-19 related pregnancy concern and psychological distress.

Conclusion
The results from this study suggest that pregnant women in Ireland are experiencing increased levels of psychological distress during the Covid-19 pandemic. The findings also suggest that perceptions of control and avoidant coping are associated with psychological distress in this group and could be used as intervention targets.
Ninjinyoeito ameliorated cigarette smoke extract-induced apoptosis and inflammation through JNK signaling inhibition in human lung fibroblasts
Authors: Murata Kenta , Fujita Nina , Takahashi Ryuji 
Published: March 2022

Abstract
Background
Cigarette smoke is a major risk factor for various lung diseases, such as chronic obstructive pulmonary disease (COPD). Ninjinyoeito (NYT), a traditional Chinese medicine, has been prescribed for patients with post-illness or post-operative weakness, fatigue, loss of appetite, rash, cold limbs, and anemia. In addition to its traditional use, NYT has been prescribed for treating frailty in gastrointestinal, respiratory, and urinary functions. Further, NYT treatment can ameliorate cigarette smoke-induced lung injury, which is a destructive index in mice; however, the detailed underlying mechanism remains unknown. The purpose of this study was to investigate whether NYT ameliorates cigarette smoke-induced cell injury and inflammation in human lung fibroblasts and determine its mechanism of action.

Methods
We prepared a cigarette smoke extract (CSE) from commercially available cigarettes to induce cell injury and inflammation in the human lung fibroblast cell line HFL1. The cells were pretreated with NYT for 24 h prior to CSE exposure. Cytotoxicity and cell viability were measured by lactate dehydrogenase (LDH) cytotoxicity assay and cell counting kit (CCK)-8. IL-8 level in the cell culture medium was measured by performing Enzyme-Linked Immuno Sorbent Assay (ELISA). To clarify the mechanisms of NYT, we used CellROX Green Reagent for reactive oxygen species (ROS) production and western blotting analysis for cell signaling.

Results
Exposure of HFL1 cells to CSE for 24 h induced apoptosis and interleukin (IL)-8 release. Pretreatment with NYT inhibited apoptosis and IL-8 release. Furthermore, CSE exposure for 24 h increased the production of ROS and phosphorylation levels of p38 and JNK. Pretreatment with NYT only inhibited CSE-induced JNK phosphorylation, and not ROS production and p38 phosphorylation. These results suggest that NYT acts as a JNK-specific inhibitor.

Conclusion
NYT treatment ameliorated CSE-induced apoptosis and inflammation by inhibiting the JNK signaling pathway. Finally, these results suggest that NYT may be a promising therapeutic agent for patients with COPD.