bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exposure to a sublethal concentration of CdO nanoparticles impairs the vision of the fruit fly (Drosophila melanogaster) by disrupting histamine synthesis and recycling mechanisms
Authors: Kholy Samar El , Naggar Yahya Al 
Published: October 2022

Abstract
While there is substantial literature on potential risks associated with exposure to emerging nanomaterials, less is known about the potential effects of hazardous metallic nanoparticles on vision, as well as the mechanisms that underpin them. The fruit fly (Drosophila melanogaster) was used as an in vivo model organism to investigate the effects of exposure to a sublethal concentration (0.03 mg CdO NPs/mL, which was 20% of the LC50) on fly vision and compound eye ultrastructure. Frist, we observed a reduction in phototaxis response in treated flies but no change in locomotor activity. Because histamine (HA) has been linked to arthropod vision, we investigated HA synthesis, uptake, and recycling as a possible underlying mechanism for the observed adverse effect of CdO NPs on fly vision. This was accomplished by measuring the expression of the histamine decarboxylase (hdc) gene, which encodes the enzyme that converts the amino acid histidine to histamine (HA), as well as the expression of some genes involved in HA-recycling pathways (tan, ebony, Balat, CarT, and Lovit). The results showed that CdO NPs changed the expression levels of hdc, Lovit, tan, and eboney, indicating that HA synthesis, transport, and recycling were disrupted. Furthermore, less histamine immunolabelling was found in the head tissues of CdO NPs-treated flies, particularly in the optic lobes. We also observed and quantified CdO NP bioaccumulation in compound eye tissues, which resulted in a number of cytological changes. Phenotypic effects (undersized eyes) have also been observed in the compound eyes of F1 flies. Considering the significance of vision in an organism's survival, the findings of this study are extremely crucial, as long-term exposure to CdO NPs may result in blindness.
Mapping subsurface defects and surface deformation along the artificial levee of the Lower Tisza River, Hungary
Authors: SHEISHAH DIAA , KISS TÍMEA , BORZA TIBOR , FIALA KÁROLY , KOZÁK PÉTER , ABDELSAMEI ENAS , TÓTH CSABA , GRENERCZY GYULA , PÁLL DÁVID GERGELY , Sipos György 
Published: October 2022

Abstract
Artificial levees along alluvial rivers are major components of flood risk mitigation. This is especially true in the case of Hungary, where more than one-third of the country is threatened by floods and protected by an over 4200 km long levee system. Most of the levees were built in the 19th century. Since then, several natural and anthropogenic processes, such as compaction, erosion, Etc., could contribute to these earth structures' slow but steady deformation. Meanwhile, as construction works were scarcely documented, the structure and composition of artificial levees are not well known. Therefore, the present analysis aimed to map structural differences, possible compositional deficiencies, and sections where elevation decrease is significant along a 40 km section of the Lower Tisza River. Investigations were conducted by real-time kinematic GPS (RTK-GPS) and ground penetrating radar (GPR). Onsite data acquisition was complemented with an analysis using a Persistent Scatterer Synthetic Aperture Radar (PSI) to assess general surface deformation. GPR data have shown that levee structures can significantly vary even in a few km on sections with the same construction history. GPR profiles showed several anomalies, including structural and compositional discontinuities and local features. The penetration depth of GPR varied between 3 and 4 m. Based on height measurements, the mean elevation of the levee crown decreased by 8 cm in a 40-year time span. However, elevation decrease could reach up to 30 cm at some locations. Sections affected by structural anomalies, compositional changes, and increased surface subsidence are especially sensitive to floods when measurement results are compared to flood phenomena archives.
Metal(loid)s in aquatic products and their potential health risk
Authors: Hu Shi-Lin , Chen Xiao-Chen , Xue Ying-Xin , Zhi Li-Ying , Yang Yu-Han , Zhu Yong-Guan , Xue Xi-Mei 
Published: October 2022

Abstract
Aquatic products decrease environmental burdens and improve human health by supplying various essential nutrients, while their contamination with metal(loid)s could pose health risks to humans through food chain. In this study, the concentrations, trophic magnification and health risks of multiple metal(loid)s in various aquatic products were analyzed, including arsenic, cadmium, mercury, lead, cobalt, manganese, iron, copper, nickel and zinc. The results showed that the total concentrations of the metal(loid)s in aquatic foods were in the following order: seaweeds > shellfish > cephalopods > crustaceans > saltwater fish > freshwater fish. Arsenic speciation analysis indicated that high concentrations of arsenolipids were detected in lower trophic organisms. The maximum level of organoarsenic in seafood should be evaluated because of the potential toxicity of arsenolipids and arsenosugar metabolites. Weekly intake of metal(loid)s was far below the recommended provisional tolerable weekly intake even with excessive consumption of aquatic products. The hazard index was above 1 for excessive consumers, while our results also indicated that the health risks from aquatic products could be sharply decreased by reducing the ingestion of seaweeds and cephalopods. The study provided valuable guidance on the consumption of aquatic products by the general public.
A comprehensive methodology to support decision-making for additive manufacturing of short carbon-fiber reinforced polyamide 12 from energy, cost and mechanical perspectives
Authors: Gentil Thibault Le , Therriault Daniel , Kerbrat Olivier 
Published: October 2022

Abstract
Additive manufacturing (AM) technologies have transformed manufacturing, by providing greater control over material deposition and consumption. Thanks to greater customization and their high strength-to-mass ratio, AM with composite materials has grown significantly over the past few years. Main focus in research area are on improving printing precision and higher production rates. However there is a lack of thorough analysis on the energy consumption of Fused Filament Fabrication (FFF) machines for composite manufacturing. We designed an experimental method, based on flow analysis for measuring the impact of temperature parameters on total cost, energy consumption, and tensile resistance of composite parts made by FFF. As the user should be able to improve FFF efficiency regarding economic, energy and technical aspects and obtain recommendations for setting up and using the machine. This study confirms that combining traditional economic and technical indicators (total cost and tensile resistance) to emerging energy indicators (specific energy consumption) can be successfully applied to additive manufacturing to provide an overview of those impacts. Results are yielding information to support optimization investigations depending on the need and goal. For example, two tested parameter combinations that offer similar tensile properties (4% reduction in tensile resistance compared to best combination) show a 20% difference in energy consumption.
Comparison and Fusion Prediction Model for Lung Adenocarcinoma with Micropapillary and Solid Pattern Using Clinicoradiographic, Radiomics and Deep Learning Features
Authors: Wang Fen , Wang Cheng-Long , Yi Yin-Qiao , Zhang Teng , Zhong Yan , Zhu Jia-jia , Li Hai , Yang Guang , Yu Tong-Fu , Xu Hai , Yuan Mei 
Published: October 2022

Abstract
Purpose: To investigate whether the combination scheme of deep learning score (DL-score) and radiomics can improve preoperative diagnosis in the presence of micropapillary/ solid (MPP/SOL) patterns in lung adenocarcinoma (ADC).
Material and Methods: A retrospective cohort of 514 confirmed pathologically lung ADC in 512 patients after surgery was enrolled. The clinicoradiographic model (model 1) and radiomics model (model2) were developed with logistic regression. The deep learning model (model3) was constructed based on the deep learning score (DL-score). The combine model(model4) was based on DL-score and R-score and clincoradiographic variables. The performance of these models was evaluated with area under the receiver operating characteristic curve (AUC) and compared using DeLong's test. The prediction nomogram was plotted and clinical utility was depicted with decision curve.
Results: The performance of model1, model2, model3 and model4 was supported by AUCs of 0.848, 0.896,0.906, 0.921 in the Testing set, respectively. These models existed statistical significance (model4 vs model3, P=0.016; model4 vs model1, P=0.009, respectively). The decision curve analysis (DCA) demonstrated that model 4 predicting the lung ADC with MPP/SOL structure would be more beneficial than the model 1 but comparable with the model2 and model3.
Conclusion: The combined model can improve preoperative diagnosis in the presence of MPP/SOL pattern in lung ADC in clinical practice.
Integration of nutrition assessment counselling and support interventions in health service delivery and respective drivers: A case study of Tororo district, Uganda
Authors: Namukose Samalie , Wamani Henry , Makumbi Fredrick Edward , Maina Gakenia Wamuyu , Kiwanuka Suzanne N 
Published: October 2022

Abstract
Background: Uganda embraced the Nutrition Assessment Counselling and Support (NACS) approach since 2009 as a health system strengthening approach to deliver quality nutrition services for better health and nutrition outcomes of the population. Whilst government and partners provided support for NACS, the extent of its integration in Uganda is unknown. Using Tororo district as a case study, we assessed the extent of NACS assimilation into the health system functions and the respective drivers to inform NACS scale up.
Methods: This study used a mixed method design to assess the extent of NACS integration in the health system and the respective drivers. We conducted facilitated panel discussions in 17 health facilities with 4-8 health staff per facility guided by a semi-structured questionnaire. Through consensus, final scores were allotted to each of the health system functions on a five point scoring scale ranging from 1 if not done nor integrated to 5 if NACS was fully integrated. Data were captured and mean scores analysed in excel. Findings were presented in bar and spider charts. Drivers for integration were deductively extracted from the key informant interviews, in-depth interviews and focus group discussions using Atlas.ti 9 and thematic analysis to complement the quantitative data.
Results: NACS integration in the health system functions was partial with a mean score of 2.9. The best integrated function was service delivery (3.8) followed by health work force (3.7), health information (3.3), community support system (3.0) and governance and leadership (3.0). Health financing (2.2) and health supplies functions (1.5) were least integrated. Hospitals (3.0) had better integration than HCIV (2.4) and HCIII (2.6). The key drivers for integration were; good leadership, increased funding, competent staff, quality improvement approaches, availability of nutrition logistics and supplies, health and nutrition education talks, and community dialogues.
Conclusion: NACS integration in the health system functions was sub-optimal suggestive of a weak nutrition integrated system. Good leadership, capacity building in all health system functions, increased funding, recruitment of nutritionists, nutrition supplies and logistics are important for a fully integrated nutrition service delivery.
Injection partnership characteristics and HCV status associations with syringe and equipment sharing among people who inject drugs
Authors: Mackesy-Amiti Mary Ellen , Boodram Basmattee , Page Kimberly , Latkin Carl 
Published: October 2022

Abstract
Background. Sharing of syringes is the leading transmission pathway for hepatitis C (HCV) infections. The extent to which HCV can spread among people who inject drugs (PWID) is largely dependent on syringe-sharing network factors. Our study aims to better understand partnership characteristics and syringe and equipment sharing with those partners, including measures of relationship closeness, sexual activity, and social support, as well as self and partner HCV status to better inform interventions for young urban and suburban PWID.
Methods. Baseline interviews from a longitudinal network-based study of young (aged 18-30) PWID participants (egos) and their injection, sexual, and support network members (alters) (n=276 egos and 929 injection alters) in metropolitan Chicago. All participants completed a baseline computer-assisted interviewer-administered questionnaire and an egocentric network survey.
Results. Correlates of syringe and ancillary equipment sharing were found to be similar. Sharing was more likely to occur in mixed-gender dyads. Participants were more likely to share syringes and equipment with alters who lived in the same household, who they saw every day, who they trusted, who they had an intimate relationship with that included condomless sex, and who provided emotional or informational support. PWID who had tested HCV negative within the past year were less likely to share syringes with an HCV positive partner compared to those who did not know their status.
Conclusion. PWID regulate their syringe and other injection equipment sharing to some extent by sharing preferentially with injection partners with whom they have a close personal or intimate relationship, and whose HCV status they are more likely to know. Our findings underscore the need for risk interventions and HCV treatment strategies to consider the social context of syringe and equipment sharing within partnerships.
Metal surfaces catalyze polarization-dependent hydride transfer from H2
Authors: Wang Hai-Xu , Toh Wei Lun , Tang Bryan , Surendranath Yogesh 
Published: October 2022

Abstract
Hydride transfer is a critical elementary reaction step that spans biological catalysis, organic synthesis, and energy conversion. Conventionally, hydride transfer reactions are carried out using (bio)molecular hydride reagents under homogeneous conditions. Herein, we report a conceptually distinct heterogeneous hydride transfer reaction via the net electrocatalytic hydrogen reduction reaction (HRR) which reduces H2 to hydrides. The reaction proceeds by H2 dissociative adsorption on a metal electrode to form surface M−H species, which are then negatively polarized to drive hydride transfer to molecular hydride acceptors with up to 95% Faradaic efficiency. We find that the hydride transfer reactivity of surface M−H species is highly tunable and its thermochemistry depends on the applied potential in a Nernstian fashion. Thus, depending on the electrode potential, we observe that the thermodynamic hydricity of Pt−H on the same Pt electrode can continuously span a range of >40 kcal mol−1. This work highlights the critical role of electrical polarization on heterogeneous hydride transfer reactivity and establishes a sustainable strategy for accessing reactive hydrides directly from H2.
Depression and 24 Gastrointestinal Diseases: A Mendelian Randomization Study
Authors: Yuan Shuai , Ruan Xixian , Chen Jie , Sun Yuhao , Zhang Yao , Zhao Jianhui , Wang Xiaoyan , Li Xue , Larsson Susanna 
Published: October 2022

Abstract
The causality of the association between depression and gastrointestinal diseases is undetermined. We conducted a Mendelian randomization (MR) investigation to systematically explore the associations of depression with 24 gastrointestinal diseases. Independent genetic variants associated with depression at the genome-wide significance level were selected as instrumental variables. Genetic associations with 24 gastrointestinal diseases were obtained from the UK Biobank study, the FinnGen study, and large consortia. Multivariable MR analysis was conducted to explore the mediation effects of body mass index, cigarette smoking, and type 2 diabetes. After multiple-testing corrections, genetic liability to depression was associated with increased risk of irritable bowel syndrome, non-alcohol fatty liver disease, alcoholic liver disease, gastroesophageal reflux, chronic pancreatitis, duodenal ulcer, chronic gastritis, gastric ulcer, diverticular disease, cholelithiasis, acute pancreatitis, and ulcerative colitis. The associations of genetic liability to depression with non-alcoholic fatty liver disease was largely mediated by body mass index. Genetic liability to smoking initiation mediated half of association of depression with acute pancreatitis. This MR investigation suggests that depression may have a causal role in the development of several gastrointestinal diseases.
Oxytocin vs. placebo effects on intrusive memory consolidation using a trauma film paradigm: a randomized, controlled experimental study in healthy women
Authors: Maslahati Tolou , Wingenfeld Katja , Hellmann-Regen Julian , Kraft Julia , Lyu Jing , Keinert Marie , Voß Aline , Cho An Bin , Ripke Stephan , Otte Christian , Schultebraucks Katharina , Roepke Stefan 
Published: October 2022

Abstract
Oxytocin administration during a trauma analogue has been shown to increase intrusive memories, which are a core symptom of Post-Traumatic Stress Disorder (PTSD). However, it is unknown whether oxytocin influences the acquisition or the consolidation of the trauma. The current study investigates the effect of the activation of the oxytocin system during the consolidation of an analogue trauma on the formation of intrusive memories over four consecutive days and whether this effect is influenced by individual neurobiological, genetic, or psychological factors. We conducted a randomized double-blind placebo-controlled study in 217 healthy women. They received either a single dose of intranasal oxytocin (24 IU) or placebo after exposure to a trauma film paradigm, which reliably induces intrusive memories. We used a general random forest to examine a potential heterogeneous treatment effect of oxytocin on the consolidation of intrusive memories. Furthermore, we used a poisson regression to examine whether salivary alpha amylase activity (sAA) as a marker of noradrenergic activity and cortisol response to the film, polygenic risk score (PRS) for psychiatric disorders, and psychological factors influence the number of intrusive memories. We found no significant effect of oxytocin on the formation of intrusive memories (t(-0.85) = 201.72, p = 0.40, Cohen’s d = 0.12, 95% CI -0.02–0.26) and identified no heterogeneous treatment effect. We replicated previous associations of the PRS for PTSD, sAA and the cortisol response on intrusive memories. We further found a positive association between high trait anxiety and intrusive memories, and a negative association between the emotion regulation strategy reappraisal and intrusive memories. Data of the present study suggest that the consolidation of intrusive memories is modulated by genetic, neurobiological and psychological factors, but is not influenced by oxytocin.
Trial registration: NCT03875391.
Prognostic factors and clinical outcomes of breast cancer patients with disease progression during neoadjuvant systemic therapy
Authors: Ling Yun-Xiao , Xie Yi-Fan , Wu Huai-Liang , Wang Xiao-Fang , Ma Jin-Li , Fan Lei , Liu Guang-Yu 
Published: October 2022

Abstract
Purpose
Disease progression during neoadjuvant systemic therapy for breast cancer indicates poor prognosis, while predictors of the clinical outcomes of these patients remain unclear. By comparing the clinical outcomes of patients with different patterns of salvage treatment strategies, we try to evaluate the factors predicting distant failure and explore the favourable treatment for them.
Methods
Patients with PD during NST for stage I–III breast cancer diagnosed between 1 January 2008 and 31 July 2021 in Fudan University Shanghai Cancer Center were enrolled. Kaplan-Meier, univariate and multivariate Cox proportional hazard regressions were utilized to compare survival outcomes between different ST strategies.
Results
Among 3775 patients treated with NST, 60 (1.6%) patients encountered disease progression. A significant difference between the outcomes of patients receiving direct surgery and other salvage modalities was found (p = 0.007). Triple-negative breast cancer (p = 0.012) and not receiving direct surgery (p = 0.013) were independently associated with distant disease-free survival on multivariate analysis.
Conclusions
Predictors of distant failure in patients with PD include triple-negative breast cancer and not receiving direct surgery. We suggest that direct surgery should be considered first for operable patients. For inoperable patients, neoadjuvant radiation can increase their operability but not improve their prognosis.
The usefulness of serum tumor markers for the differential diagnosis of ACTH-dependent Cushing’s syndrome
Authors: Noriega Paulo Enrique Peinado , de Oliveira Rafael , Guerrero Diana Gabriela Zuñiga , Carrijo Marcia de Pinho , Musolino Nina Rosa Castro , Cescato Valter Angelo Sperling , Silva Gilberto Ochman da , Fragoso Maria Candida Barisson Villares , Bronstein Marcello Delano , Machado Marcio Carlos 
Published: October 2022

Abstract
Purpose. The aim of this study was to evaluate the role of serum tumor markers for the differential diagnosis of ACTH-dependent Cushing’s syndrome (ADCS).
Methods. This study included 185 patients with ADCS, 153 with Cushing’s disease (CD) and 32 with ectopic ACTH syndrome (EAS) who were evaluated between 1991 and 2019 and had at least one tumor marker measured at the time of diagnosis.
Results. At least one elevated tumor sample was verified in 33% of CD and in 72% of EAS patients. Two or more elevated tumor samples were found in 9% of CD and 44% of EAS. In CD, gastrin was the most common abnormality in 21% of cases. In EAS, urinary 24-h 5-hydroxy indol acetic acid was the most frequent alteration in 80%, followed by chromogranin in 67%. Higher concentrations and a higher percentage of patients with changes in the tumor markers gastrin, CEA and chromogranin were found in patients with EAS in relation to CD. Analyzing the best values of tumor markers to differentiate patients with EAS and CD, significant differences were found in gastrin, calcitonin, CEA and chromogranin but with an overlap between subgroups. A positive direct correlation between hormonal parameters and tumor marker data was commonly verified in patients as a whole group.
Conclusion. Abnormalities in serum tumor markers at the time of diagnosis were more common in EAS than CD patients. However, due to significant overlap between the subgroups, no single tumor marker presented high applicability for the differential diagnosis of ADCS.