bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of sensory preference and frequency of carbohydrate bar consumption by physically active people
Authors: Kiciak Agata , Czaderna Ewa , Staśkiewicz Wiktoria , Piątek Małgorzata , Bielaszka Agnieszka , Kardas Marek 
Published: October 2022

Introduction: Active lifestyles are causing an increase in interest directed toward foods, many athletes use specially formulated food products that concentrate large amounts of nutrients in a small volume, while also being easily digestible and quickly absorbed. The main objective of the study was to compare selected commercially available products prepared for physically active people with those prepared based on proprietary recipes and natural, commonly available ingredients. Material and method: The material used in the comparative study was energy bars from three sources: popular market bars from the leading manufacturers in the Polish market and available in most grocery stores, specialized bars, and bars made according to the author's recipe in imitation of the above snacks using natural ingredients. The evaluation of the use of supplements was based on the author's survey questionnaire on consumer preferences and frequency of consumption of carbohydrate products, using energy bars as an example. Results: Bars prepared according to the author's recipe received scores of 2 and 3 for taste and texture and scores of 1 and 2 for the input of basic raw materials. Evaluation of the use of supplements was carried out in a group of 147 people, the study group was dominated by people who train in cycling and running. About 65% of the respondents declared that they use energy bars. Among those who use energy bars, the largest number of respondents declared that they use specialty bars (20%), 15% of respondents use market bars and 8% make the bars themselves. Conclusions: The results of the sensory evaluation of bars prepared according to the author's recipe indicate the need to modify their composition, especially in terms of improving the texture. Carbohydrate supplements are used by respondents, especially if it is justified in the case of practicing endurance and endurance sports characterized by high intensity of training, i.e. cycling and running.
GIFAIR-FL: A Framework for Group and Individual Fairness in Federated Learning
Authors: Yue Xubo , Nouiehed Maher , Al Kontar Raed 
Published: October 2022

In this paper, we propose GIFAIR-FL, a framework that imposes group and individual fairness (GIFAIR) to federated learning (FL) settings. By adding a regularization term, our algorithm penalizes the spread in the loss of client groups to drive the optimizer to fair solutions. Our framework GIFAIR-FL can accommodate both global and personalized settings. Theoretically, we show convergence in nonconvex and strongly convex settings. Our convergence guarantees hold for both independent and identically distributed (i.i.d.) and non-i.i.d. data. To demonstrate the empirical performance of our algorithm, we apply our method to image classification and text prediction tasks. Compared with existing algorithms, our method shows improved fairness results while retaining superior or similar prediction accuracy. History: Kwok-Leung Tsui served as the senior editor for this article. Funding: This work was supported by NSF CAREER [Grant 2144147]. Data Ethics & Reproducibility Note: The code capsule is available on Code Ocean at https://codeocean.com/capsule/2590027/tree/v1 and in the e-Companion to this article (available at https://doi.org/10.1287/ijds.2022.0022 ).
Multiple health-related behaviours among Fly-In Fly-Out workers in the mining industry in Australia: A cross-sectional survey during the COVID-19 pandemic
Authors: Asare Bernard Yeboah-Asiamah , Thomas Elizabeth , Affandi Jacquita S. , Schammer Myles , Harris Chris , Kwasnicka Dominika , Powell Daniel , Reid Christopher M. , Robinson Suzanne 
Published: October 2022

Background
Fly-In-Fly-Out (FIFO) workers travel to work at isolated locations, and rotate continuous workdays with leave periods at home, and such work practice is common in the offshore oil and gas and onshore mining industry worldwide. The COVID-19 pandemic and accompanying public health actions appear to have had a negative impact on several health-related behaviours among the general population. However, little is known about the impact of the COVID-19 pandemic on the health behaviours of FIFO workers, who have shown higher pre-pandemic rates of risky behaviours than the general population in Australia. This study examined the health-related behaviours of FIFO workers in the mining industry during the COVID-19 pandemic.

Methods
A descriptive cross-sectional study was conducted. FIFO workers from an Australian mining company who underwent COVID-19 screening between May and November 2020 completed an online survey about their regular health-related behaviours. The independent sample t-test and Pearson’s chi-square test where appropriate were conducted to examine the differences between males and females for the behavioural outcomes.

Results
A total of 768 FIFO workers (633 males and 135 females) participated in the study. Prevalence of smoking was high (32%). Males smoked more cigarettes per day than females (15.2±7.0 vs 13.1±7.1, p = .174). Most participants (74.7%) drank alcohol on more than two days per week. Compared to females, more males (20.2% vs 8.0%) consumed alcohol at short-term harmful levels (p = .010). About a third (34.4%) of the workers (33.5% of males and 38.5% of females, p = .264) engaged in inadequate moderate-vigorous exercises/physical activity. About a third (33.1%) of workers (33.7% of males and 30.4% of females; p = .699) had multiple risk behaviours.

Conclusions
Prevalence of multiple risk behaviours was high. Interventions aimed at the prevention of risky health-related behaviours should target the different behavioural patterns and may require emphasis on gender-informed techniques particularly when addressing alcohol consumption.
Percutaneous transhepatic or endoscopic ultrasound-guided biliary drainage in malignant distal bile duct obstruction using a self-expanding metal stent: Study protocol for a prospective European multicenter trial (PUMa trial)
Authors: Schmitz Daniel , Valiente Carlos T. , Dollhopf Markus , Perez-Miranda Manuel , Küllmer Armin , Gornals Joan , Vila Juan , Weigt Jochen , Voigtländer Torsten , Redondo-Cerezo Eduardo , von Hahn Thomas , Albert Jörg , vom Dahl Stephan , Beyna Torsten , Hartmann Dirk , Franck Franziska , García-Alonso Francisco Javier , Schmidt Arthur , Garcia-Sumalla Albert , Arrubla Amaia , Joerdens Markus , Kleemann Tobias , Tomo José Ramón Aparicio , Grassmann Felix , Rudi Jochen 
Published: October 2022

Background
Endoscopic ultrasound-guided biliary drainage (EUS-BD) was associated with better clinical success and a lower rate of adverse events (AEs) than fluoroscopy-guided percutaneous transhepatic biliary drainage (PTBD) in recent single center studies with mainly retrospective design and small case numbers (< 50). The aim of this prospective European multicenter study is to compare both drainage procedures using ultrasound-guidance and primary metal stent implantation in patients with malignant distal bile duct obstruction (PUMa Trial).

Methods
The study is designed as a non-randomized, controlled, parallel group, non-inferiority trial. Each of the 16 study centers performs the procedure with the best local expertise (PTBD or EUS-BD). In PTBD, bile duct access is performed by ultrasound guidance. EUS-BD is performed as an endoscopic ultrasound (EUS)-guided hepaticogastrostomy (EUS-HGS), EUS-guided choledochoduodenostomy (EUS-CDS) or EUS-guided antegrade stenting (EUS-AGS). Insertion of a metal stent is intended in both procedures in the first session. Primary end point is technical success. Secondary end points are clinical success, duration pf procedure, AEs graded by severity, length of hospital stay, re-intervention rate and survival within 6 months. The target case number is 212 patients (12 calculated dropouts included).

Discussion
This study might help to clarify whether PTBD is non-inferior to EUS-BD concerning technical success, and whether one of both interventions is superior in terms of efficacy and safety in one or more secondary endpoints. Randomization is not provided as both procedures are rarely used after failed endoscopic biliary drainage and study centers usually prefer one of both procedures that they can perform best.

Trial registration
ClinicalTrials.gov ID: NCT03546049 (22.05.2018).
The lymphocyte-specific protein tyrosine kinase-specific inhibitor A-770041 attenuates lung fibrosis via the suppression of TGF-β production in regulatory T-cells
Authors: Kagawa Kozo , Sato Seidai , Koyama Kazuya , Imakura Takeshi , Murakami Kojin , Yamashita Yuya , Naito Nobuhito , Ogawa Hirohisa , Kawano Hiroshi , Nishioka Yasuhiko 
Published: October 2022

BackgroundLymphocyte-specific protein tyrosine kinase (Lck) is a member of the Src family of tyrosine kinases. The significance of Lck inhibition in lung fibrosis has not yet been fully elucidated, even though lung fibrosis is commonly preceded by inflammation caused by infiltration of T-cells expressing Lck. In this study, we examined the effect of Lck inhibition in an experimental mouse model of lung fibrosis. We also evaluated the effect of Lck inhibition on the expression of TGF-β1, an inhibitory cytokine regulating the immune function, in regulatory T-cells (Tregs).MethodsLung fibrosis was induced in mice by intratracheal administration of bleomycin. A-770041, a Lck-specific inhibitor, was administrated daily by gavage. Tregs were isolated from the lung using a CD4+CD25+Regulatory T-cell Isolation Kit. The expression ofTgfbon Tregs was examined by flow cytometry and quantitative polymerase chain reaction. The concentration of TGF-β in bronchoalveolar lavage fluid (BALF) and cell culture supernatant from Tregs was quantified by an enzyme-linked immunosorbent assay.ResultsA-770041 inhibited the phosphorylation of Lck in murine lymphocytes to the same degree as nintedanib. A-770041 attenuated lung fibrosis in bleomycin-treated mice and reduced the concentration of TGF-β in BALF. A flow-cytometry analysis showed that A-770041 reduced the number of Tregs producing TGF-β1 in the lung. In isolated Tregs, Lck inhibition by A-770041 decreased theTgfbmRNA level as well as the concentration of TGF-β in the supernatant.ConclusionsThese results suggest that Lck inhibition attenuated lung fibrosis by suppressing TGF-β production in Tregs and support the role of Tregs in the pathogenesis of lung fibrosis.
Comparing the cobas Influenza A/B Nucleic acid test for use on the cobas Liat System (Liat) with rapid antigen tests for clinical management of Japanese patients at the point of care
Authors: Mikamo Hiroshige , Koizumi Yusuke , Yamagishi Yuka , Asai Nobuhiro , Miyazono Yuko , Shinbo Toshikazu , Horie Michiko , Togashi Kenichi , Robbins Elissa M. , Hirotsu Nobuo 
Published: October 2022

Background
Rapid diagnosis of influenza is critical in preventing the spread of infection and ensuring patients quickly receive antiviral medication to reduce the severity and duration of influenza symptoms, whilst controlling the spread of the causative virus. In Japan patients are often administered anti-influenza medication following a positive rapid antigen detection test (RADT) result. However, the sensitivity of RADTs can lead to false negative results. The cobas® Influenza A/B Nucleic acid test for use on the cobas Liat® System (Liat) is a molecular point-of-care method that can provide a more sensitive alternative to RADTs for rapid influenza diagnosis and treatment.

Methods
In this prospective multicenter study, diagnostic performance of the Liat test was compared with RADTs in patients presenting with influenza-like-illness. Test performance was also assessed by time since symptom onset.

Results
Of 419 patients enrolled, 413 were evaluable for all designated tests. Most patients had type-A infection, and only one patient had influenza type B. In 413 patients, the sensitivity and specificity (95% CI) of the Liat test were 99.5% (97.2–99.9%) and 99.5% (97.4–99.9%), respectively, and were 79.7% (73.5–84.7%) and 95.4% (91.7–97.5%) for RADTs. For patients tested <12 hours from symptom onset, the Liat test had significantly higher sensitivity than RADTs (p<0.0001).

Conclusion
Overall, compared with standard of care RADTs, the Liat test was more sensitive and specific in children and adults, particularly in the early stages of infection. Greater sensitivity can enable earlier diagnosis and may better inform appropriate antiviral treatment decisions.
Clinical and histopathological study of renal biopsy in Nepalese children: A single center experience
Authors: Amatya Manim , Pant Anil Dev 
Published: October 2022

BackgroundGlomerular diseases are important causes of morbidity and mortality among children in developing countries. Renal biopsy is the gold standard for determining histological diagnosis, prognosis, and therapy options. This study aimed to investigate the clinical, histopathological, and direct immunofluorescence findings of renal biopsy results in Nepalese children under 18 years old.MethodsIn this retrospective cross-sectional study, the available data from children who had undergone kidney biopsy between 2016 and the end of 2020 were evaluated. Demographic data, indications of biopsy, histopathologic findings, and direct immunofluorescence findings were collected and presented.ResultsThe mean age of the patients was 12.14 ± 4.07 years. Male/female ratio was 1:1. The majority of biopsy cases were aged between 11–15 years of age. The most common indication for biopsy in children was nephrotic syndrome (68.25%). Lupus nephritis with 28 cases (22.22%) had the highest frequency in overall renal biopsies. Minimal change disease (MCD) with 22 cases (17.46%) followed by Ig A nephropathy with 16 cases (12.69%) were the most frequent primary glomerulonephritis. Lupus nephritis showed full house positivity, and MCD showed full house negativity in all Direct immunofluorescence (DIF) parameters, whereas immunoglobulin A nephropathy showed 100% positivity in Ig A in DIF.ConclusionsNephrotic syndrome was the most common indication for renal biopsy. The most common primary glomerulonephritis was MCD, while secondary glomerulonephritis was lupus nephritis. Clinical data, light microscopy, and direct DIF played an integral role in the overall final diagnosis.
Ameliorative effects of half-dose saffron and chamomile combination on Psycho-endocrinological changes in a diabetic murine model
Authors: Ahmad Saara , Rafiq Hamna , Khan Asra , Tikmani Prashant , Batool Zehra , Tabassum Saiqa , Arain Fazal , Siddiqi Salman , Khaliq Saima , Amin Faiq , Wasim Muhammad , Haider Saida 
Published: October 2022

IntroductionDiabetes mellitus is a chronic metabolic disorder with an increasing prevalence worldwide. Reduction in blood insulin level alters brain function by inducing oxidative stress with changes in dopamine and norepinephrine neurotransmission, ultimately leading to neuropsychological symptoms. The efficacy of currently available psychotropic drugs is not satisfactory. Therefore, this study was conducted to explore the beneficial effects of a combination of the natural herbs, saffron and chamomile, in treating diabetes and its resultant neuropsychological effects using a rodent model of diabetes mellitus.MethodThe rats were randomly divided in to eight groups (n = 10), healthy control (HC), diabetic control (DC) and six groups of diabetic rats treated with various concentrations and combinations of saffron and chamomile. Diabetic treatment groups individually received methanolic extract and water decoction of chamomile (30 mg/kg) and saffron (10mg/kg) and their combined half doses (saffron 5mg/kg and chamomile 15mg/kg) for two weeks. Open field test (OFT) and forced swim test (FST) were used to measure the anxiolytic and antidepressant effects of herbs, respectively. Finally, biochemical, and neurochemical estimations were made.ResultsThe present study suggests the therapeutic effects of herbs especially in co-administrated decoction, against diabetes with improved antioxidant profile and enhanced levels of dopamine and norepinephrine. Anxiolytic and antidepressant effects were evident with improvements in the OFT and FST. Examination of the cortex of the diabetic group revealed cellular damage and tangle formation, which indicates advanced stages of dementia.ConclusionThis study shows that the use of a combination of saffron and chamomile improves diabetes control and reduces its related psychiatric effects.
Healthcare utilization in children across the care continuum during the COVID-19 pandemic
Authors: Schroeder Alan R. , Dahlen Alex , Purington Natasha , Alvarez Francisco , Brooks Rona , Destino Lauren , Madduri Gayatri , Wang Marie , Coon Eric R. 
Published: October 2022

ObjectivesHealthcare utilization decreased during the COVID-19 pandemic, likely due to reduced transmission of infections and healthcare avoidance. Though various investigations have described these changing patterns in children, most have analyzed specific care settings. We compared healthcare utilization, prescriptions, and diagnosis patterns in children across the care continuum during the first year of the pandemic with preceding years.Study designUsing national claims data, we compared enrollees under 18 years during the pre-pandemic (January 2016 –mid-March 2020) and pandemic (mid-March 2020 through March 2021) periods. The pandemic was further divided into early (mid-March through mid-June 2020) and middle (mid-June 2020 through March 2021) periods. Utilization was compared using interrupted time series.ResultsThe mean number of pediatric enrollees/month was 2,519,755 in the pre-pandemic and 2,428,912 in the pandemic period. Utilization decreased across all settings in the early pandemic, with the greatest decrease (76.9%, 95% confidence interval [CI] 72.6–80.5%) seen for urgent care visits. Only well visits returned to pre-pandemic rates during the mid-pandemic. Hospitalizations decreased by 43% (95% CI 37.4–48.1) during the early pandemic and were still 26.6% (17.7–34.6) lower mid-pandemic. However, hospitalizations in non-psychiatric facilities for various mental health disorders increased substantially mid-pandemic.ConclusionHealthcare utilization in children dropped substantially during the first year of the pandemic, with a shift away from infectious diseases and a spike in mental health hospitalizations. These findings are important to characterize as we monitor the health of children, can be used to inform healthcare strategies during subsequent COVID-19 surges and/or future pandemics, and may help identify training gaps for pediatric trainees. Subsequent investigations should examine how changes in healthcare utilization impacted the incidence and outcomes of specific diseases.
ICD-10 based machine learning models outperform the Trauma and Injury Severity Score (TRISS) in survival prediction
Authors: Tran Zachary , Verma Arjun , Wurdeman Taylor , Burruss Sigrid , Mukherjee Kaushik , Benharash Peyman 
Published: October 2022

Background
Precise models are necessary to estimate mortality risk following traumatic injury to inform clinical decision making or quantify hospital performance. The Trauma and Injury Severity Score (TRISS) has been the historical gold standard in survival prediction but its limitations are well-characterized. The present study used International Classification of Diseases 10th Revision (ICD-10) injury codes with machine learning approaches to develop models whose performance was compared to that of TRISS.

Methods
The 2015–2017 National Trauma Data Bank was used to identify patients following trauma-related admission. Injury codes from ICD-10 were grouped by clinical relevance into 1,495 variables. The TRISS score, which comprises the Injury Severity Score, age, mechanism (blunt vs penetrating) as well as highest 24-hour values for systolic blood pressure (SBP), respiratory rate (RR) and Glasgow Coma Scale (GCS) was calculated for each patient. A base eXtreme gradient boosting model (XGBoost), a machine learning technique, was developed using injury variables as well as age, SBP, RR, mechanism and GCS. Prediction of in-hospital survival and other in-hospital complications were compared between both models using receiver operating characteristic (ROC) and reliability plots. A complete XGBoost model, containing injury variables, vitals, demographic information and comorbidities, was additionally developed.

Results
Of 1,380,740 patients, 1,338,417 (96.9%) survived to discharge. Compared to survivors, those who died were older and had a greater prevalence of penetrating injuries (18.0% vs 9.44%). The base XGBoost model demonstrated a greater receiver-operating characteristic (ROC) than TRISS (0.950 vs 0.907) which persisted across sub-populations and secondary endpoints. Furthermore, it exhibited high calibration across all risk levels (R2 = 0.998 vs 0.816). The complete XGBoost model had an exceptional ROC of 0.960.

Conclusions
We report improved performance of machine learning models over TRISS. Our model may improve stratification of injury severity in clinical and quality improvement settings.
Preference of homebirth and associated factors among pregnant women in Arba Minch health and demographic surveillance site, Southern Ethiopia
Authors: Alemu Solomon Seyife , Ketema Teklemariam Gultie , Tessema Kassahun Fikadu , Feyisa Jira Wakoya , Yimer Awol Arega , Kebede Birhanu Negese 
Published: October 2022

Background
Home birth preference is the need of pregnant women to give birth at their home with the help of traditional (unskilled) birth attendants. Homebirth with unskilled birth attendants during childbirth is the main leading indicator for maternal and newborn death. In Ethiopia, numbers of women prefer homebirth which is assisted by unskilled personal. However, there is no information regarding the problem in the Arba Minch zuria woreda. Therefore, it is important to identify prevalence of preference of homebirth and associated factors.

Objectives
This study aimed to assess the preference of home birth and associated factors among pregnant women in Arba Minch health and demographic surveillance site.

Method and materials
A community-based cross-sectional study was conducted among pregnant women in Arba Minch health and demographic surveillance site, from May 1 to June 1, 2021. Using simple random sampling technique, 416 study samples were selected. Data were collected by interviewer-administered questionnaire. Data were coded and entered into Epi-Data version 4.4.2.1 computer software and exported to Statistical Package for Social Sciences software version 25 for analysis. Bi-variable binary logistic regression for the selection of potential candidate variables at p-value < 0.25 for multivariable analysis and multivariable binary logistic regression to identify the association between homebirth preference and independent variables were carried out. The level of statistical significance was declared at a p-value < 0.05.

Result
In this study, in Arba Minch demographic health surveillance site, the prevalence of preference of pregnant women to give birth at their home was 24% [95%CI: (19.9%-28.2%)] The factors significantly associated with the preference of home birth were husband involvement in decision making [AOR: 0.14 (0.05–0.38)], no access of road for transportation [AOR: 2.4 (1.2–5.18)], not heard about the benefit of institutional birth [AOR: 5.3 (2.3–12.2)], poor knowledge about danger signs [AOR: 3 (1.16–7.6)], negative attitude toward services [AOR: 3.1 (1.19–8.02)], and high fear to give birth at institution [AOR: 5.12 (2.4–10.91)].

Conclusions
In Arba Minch demographic health surveillance site, the prevalence of preference of pregnant women to give birth at their home was 24%. Husband involvement in decision making, no access of road for transportation, not heard about the benefit of institutional birth, poor knowledge about danger signs, negative attitude toward services, and high fear to give birth at health institutions were factors significantly associated with the preference of home birth.