bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel molecular subtypes and risk model based on inflammatory response-related lncrnas for bladder cancer
Authors: Tang Fucai , Zhang Jiahao , Lu Zechao , Liao Haiqin , Hu Chuxian , Mai Yuexue , Lai Yongchang , Lu Zeguang , Tang Zhicheng , Li Zhibiao , He Zhaohui 
Published: August 2022

Abstract
Background
Inflammation and long noncoding RNAs (lncRNAs) are gradually becoming important in the development of bladder cancer (BC). Nevertheless, the potential of inflammatory response-related lncRNAs (IRRlncRNAs) as a prognostic signature remains unexplored in BC.

Methods
The Cancer Genome Atlas (TCGA) provided RNA expression profiles and clinical information of BC samples, and GSEA Molecular Signatures database provided 1171 inflammation-related genes. IRRlncRNAs were identified using Pearson correlation analysis. After that, consensus clustering was performed to form molecular subtypes. After performing least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression analyses, a risk model constructed based on the prognostic IRRlncRNAs was validated in an independent cohort. Kaplan–Meier (KM) analysis, univariate and multivariate Cox regression, clinical stratification analysis, and time-dependent receiver operating characteristic (ROC) curves were utilized to assess clinical effectiveness and accuracy of the risk model. In clusters and risk model, functional enrichment was investigated using GSEA and GSVA, and immune cell infiltration analysis was demonstrated by ESTIMATE and CIBERSORT analysis.

Results
A total of 174 prognostic IRRlncRNAs were confirmed, and 406 samples were divided into 2 clusters, with cluster 2 having a significantly inferior prognosis. Moreover, cluster 2 exhibited a higher ESTIMATE score, immune infiltration, and PD-L1 expression, with close relationships with the inflammatory response. Further, 12 IRRlncRNAs were identified and applied to construct the risk model and divide BC samples into low-risk and high-risk groups successfully. KM, ROC, and clinical stratification analysis demonstrated that the risk model performed well in predicting prognosis. The risk score was identified as an independently significant indicator, enriched in immune, cell cycle, and apoptosis-related pathways, and correlated with 9 immune cells.

Conclusion
We developed an inflammatory response-related subtypes and steady prognostic risk model based on 12 IRRlncRNAs, which was valuable for individual prognostic prediction and stratification and outfitted new insight into inflammatory response in BC.
Does swab type matter? Comparing methods for Mannheimia haemolytica recovery and upper respiratory microbiome characterization in feedlot cattle
Authors: Crosby William B. , Pinnell Lee J. , Richeson John T. , Wolfe Cory , Castle Jake , Loy John Dustin , Gow Sheryl P. , Seo Keun Seok , Capik Sarah F. , Woolums Amelia R. , Morley Paul S. 
Published: August 2022

Abstract
Background
Bovine respiratory disease (BRD) is caused by interactions among host, environment, and pathogens. One standard method for antemortem pathogen identification in cattle with BRD is deep-guarded nasopharyngeal swabbing, which is challenging, costly, and waste generating. The objective was to compare the ability to recover Mannheimia haemolytica and compare microbial community structure using 29.5 inch (74.9 cm) deep-guarded nasopharyngeal swabs, 16 inch (40.6 cm) unguarded proctology swabs, or 6 inch (15.2 cm) unguarded nasal swabs when characterized using culture, real time-qPCR, and 16S rRNA gene sequencing. Samples for aerobic culture, qPCR, and 16S rRNA gene sequencing were collected from the upper respiratory tract of cattle 2 weeks after feedlot arrival.

Results
There was high concordance of culture and qPCR results for all swab types (results for 77% and 81% of sampled animals completely across all 3 swab types for culture and qPCR respectively). Microbial communities were highly similar among samples collected with different swab types, and differences identified relative to treatment for BRD were also similar. Positive qPCR results for M. haemolytica were highly concordant (81% agreed completely), but samples collected by deep-guarded swabbing had lower amounts of Mh DNA identified (Kruskal–Wallis analysis of variance on ranks, P < 0.05; Dunn-test for pairwise comparison with Benjamini–Hochberg correction, P < 0.05) and lower frequency of positive compared to nasal and proctology swabs (McNemar’s Chi-square test, P < 0.05).

Conclusions
Though differences existed among different types of swabs collected from individual cattle, nasal swabs and proctology swabs offer comparable results to deep-guarded nasopharyngeal swabs when identifying and characterizing M. haemolytica by culture, 16S rRNA gene sequencing, and qPCR.
What is the best prophylaxis against venous thromboembolism in Asians following total knee arthroplasty? A systematic review and network meta-analysis
Authors: Wong Soon Yaw Walter , Ler Fen Li Stephanie , Sultana Rehena , Bin Abd Razak Hamid Rahmatullah 
Published: August 2022

Abstract
Purpose
Asians have a low venous thromboembolism (VTE) incidence following total knee arthroplasty (TKA). This systematic review and network meta-analysis was conducted to evaluate the best prophylaxis against VTE in Asians following total knee arthroplasty in current literature.

Materials and Methods
A systematic search of PubMed, Embase and CINAHL was conducted in adherence with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Prophylaxis types were separated into low-molecular-weight heparin (LMWH), novel oral anti-coagulants (NOAC), mechanical-only prophylaxis (MOP) and no prophylaxis (NP). The primary outcome was VTE incidence, grouped according to diagnosis modality (ultrasound, venography, clinical). The secondary outcome was bleeding incidence, grouped into minor and major bleeding.

Results
Fourteen eligible articles, totalling 4259 patients, were pooled with the following significant results: NOACs had lower venography-diagnosed VTE incidence than LMWH (12.77%, p = 0.02) and NP (20.64, p < 0.001). MOP had lower venography-diagnosed VTE incidence than LMWH (23.72%, p < 0.001), NOACs (10.95%, p < 0.001) and NP (31.59%, p < 0.001) but, interestingly, a statistically higher ultrasound-diagnosed VTE incidence than LMWH (6.56%, p = 0.024) and NP (4.88%, p = 0.026). No significant differences were observed between prophylaxis types for symptomatic VTE, pulmonary embolism (PE) or death. LMWH and NOACs had a higher minor bleeding incidence than NP (11.71%, p < 0.001 and 6.33%, p < 0.02, respectively). No significant differences were observed between prophylaxis types for major bleeding incidence.

Conclusion
NOACs are a superior form of chemoprophylaxis, compared with LMWH, in reducing venography-diagnosed VTE incidence with no added bleeding incidence. However, routine chemoprophylaxis may not be required as LMWH and NOACs do not appear to reduce symptomatic VTE incidence compared with MOP and NP with an increased minor bleeding incidence. Mechanical prophylaxis in the form of graduated compression stockings or intermittent pneumatic compression should be routinely considered with significantly lower rates of venography-diagnosed VTE compared with NP. On the basis of current evidence, we recommend an individualised approach to select the most appropriate prophylaxis type.
Wormhole attack detection techniques in ad-hoc network: A systematic review
Authors: Gupta Chitvan , Singh Laxman , Tiwari Rajdev 
Published: August 2022

AbstractMobile ad hoc networks (MANETs) are considered as decentralized networks, which can communicate without pre-existing infrastructure. Owning to utilization of open medium access and dynamically changing network topology, MANETs are vulnerable to different types of attacks such as blackhole attack, gray hole attack, Sybil attack, rushing attack, jellyfish attack, wormhole attack (WHA), byzantine attack, selfishness attack, and network partition attack. Out of these, worm hole attack is the most common and severe attack that substantially undermines the performance of the network and disrupts the most routing protocols. In the past two decades, numerous researchers have explored the number of techniques to detect and mitigate the effect of WHAs to ensure the safe operation of wireless networks. Hence, in this article, we mainly focus on the WHAs and present the different state of art methods, which have been employed in previous years to discern WHA in wireless networks. The existing WHA detection techniques are lacking due to usage of additional hardware, higher delay, and consumption of higher energy. Round trip time (RTT) based detection methods are showing better results as they do not require additional hardware. Machine learning (ML) techniques can also be applied to ad-hoc network for anomaly detection and has a great influence in future; therefore, ML techniques are also analyzed for WHA detection in this article. SVM technique is mostly used by the researchers for outstanding results. It has been analyzed that hybrid approach which uses the traditional detection technique and ML technique are showing better results for WHA detection. Finally, we have identified the areas where further research can be focused so that we can apply the WHA detection methods for larger topological area for more flexibility and accurate results.
A novel miniaturized V-shaped monopole antenna for GSM/WiMAX/WLAN applications
Authors: Fertas Khelil , Fertas Fouad , Challal Mouloud , Denidni Tayeb A. 
Published: August 2022

AbstractThis paper presents a novel miniaturized triple band V-shaped antenna (VSA). The miniaturization and the triple-band operation are obtained by performing two V-shaped turns on the metallic strip. The proposed antenna is printed on a single FR4 substrate and fed using the coplanar waveguide (CPW) technique. It operates in three frequency bands, [1.6–1.95 GHz], [2.8–4.4 GHz] and [5.4–5.8 GHz], with stable bidirectional radiation patterns in both E- and H-planes. A prototype of the designed antenna is fabricated and tested where the observed good agreement between simulated and experimental results indicates that the proposed structure, having a reasonably compact size of 0.0166λ02$\text{0}{\text{.}0166\lambda }_{0}^{2}$, is suitable for GSM [1800 MHz], WiMAX [3.4–3.77 GHz] and WLAN [5.725–5.825 GHz] applications.
Hybrid Indo-Trinidadian identities and tasty food: a multimodal critical discourse analysis of ‘Doubles with Slight Pepper’
Authors: Nacchia Francesco 
Published: August 2022

AbstractThe purpose of the proposed paper – which places itself within the field of Postcolonial Critical Discourse Studies (see Esposito, E. (2021).Politics, ethnicity and the postcolonial nation – a critical analysis of political discourse in the Caribbean. John Benjamins Publishing Company) – is to analyse the multi-semiotic practices contributing to the characterisation of the protagonist of Trinidadian short-film “Doubles with Slight Pepper” as a cinematic portrayal of the hybrid Indo-Trinidadian identity. By way of a Multimodal Critical Discourse Analysis (Kress, G. and van Leeuwen, T. (1996).Reading images: the grammar of visual design. Routledge, London, Kress, G. and van Leeuwen, T. (2001).Multimodal discourse. The modes and media of contemporary communications discourse. Hodder Educations, London, Kress, G. and van Leeuwen, T. (2006).Reading images: the grammar of visual design, 2nd ed. London: Routledge; O’Halloran, K.L. (2004).Multimodal discourse analysis. Continuum, London), the study aims to cast light on the strategies exploited by the filmmaker (1) to depict the protagonist (Dhani) as an in-betweener whose ambitions are inhibited by his social status stemming from generations of subjugation and misuse by colonialists; and (2) to promote Indo-Trinidadian cultural specificities. Following an introduction to the key concept of individual and collective identity with a focus on Trinidad and Tobago, and an outline of diasporic cinema as applied to the Indo-Trinidadian community, the Multimodal Critical Discourse Analysis is carried out on the verbal, non-verbal, and visual sub-corpora gathered up in sequences according to the main three identitarian traits exhibited in the short-film: ‘religion/folklore’, ‘food’, and ‘lineage’.
Ongoing oxidative stress in individuals with post-acute sequelae of COVID-19
Authors: Saleh Muhammad G. , Chang Linda , Liang Huajun , Ryan Meghann C. , Cunningham Eric , Garner Jonathan , Wilson Eleanor , Levine Andrea R. , Kottilil Shyamasundaran , Ernst Thomas 
Published: August 2022

Abstract

Objectives
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is associated with lower plasma glutathione (GSH) levels due to oxidative stress. However, plasma levels may not reflect brain GSH levels. Individuals with post-acute sequelae of COVID-19 (PASC) have a higher prevalence of cognitive fatigue, which might be related to altered brain γ-aminobutyric-acid (GABA) levels. Hence, our study aims to measure the brain GSH and GABA levels in PASC.

Methods
29 PASC participants and 24 uninfected controls were recruited for this study. Each was evaluated with detailed neuropsychiatric assessments and an edited proton MRS (Hadamard Encoding and Reconstruction of Mega-Edited Spectroscopy, HERMES) method to measure GABA and GSH concentrations in predominantly grey matter (GM) and predominantly white matter (WM) brain frontal voxels.

Results
PASC participants were 219 ± 137 days since their COVID-19 diagnosis. Nine individuals with PASC were hospitalized. Compared to controls, individuals with PASC had similar levels of GABA in both brain regions, but lower GSH and greater age-related GSH decline in the frontal GM region.

Conclusions
The lower-than-normal frontal GM GSH level in participants with PASC suggest that they have ongoing oxidative stress in the brain, and that older individuals may be even more vulnerable to oxidative stress.
Solution blow spinning polysulfone-Aliquat 336 nanofibers: synthesis, characterization, and application for the extraction and preconcentration of losartan from aqueous solutions
Authors: Montesinos-Vázquez Tanese , Pérez-Silva Irma , Galán-Vidal Carlos A. , Ibarra Israel S. , Rodríguez José A. , Páez-Hernández M. Elena 
Published: August 2022

Abstract
Nanofibers are materials used in a wide range of applications due to their unique physicochemical properties. As an alternative to the most common method of its manufacturing (electrospinning) blow spinning has been used since it has greater production efficiency and simplicity. A wide variety of polymers is used for its preparation and can be modified to improve the interaction and selectivity toward specific analytes. Thereby nanofibers have been used for the extraction or removal of organic compounds such as drugs but there are still few reports of drug extractions like losartan. In this work polysulfone-Aliquat 336 nanofibers were prepared using the blow spinning method to extract and preconcentrate losartan. The studies showed that Aliquat 336 incorporation significantly improve the extraction of losartan with polysulfone fibers. Adsorption process was thermodynamically favorable with an adsorption capacity of 15.45 mg·g−1. Thus, it was possible to extract more than 92% of initial losartan using 10 mg of polysulfone-Aliquat 336 fibers (9 and 3.5% (w/v)), at pH 6 from deionized water and synthetic wastewater. Finally, losartan preconcentration was evaluated to facilitate its quantification using ultraviolet–visible spectrometry (UV-Vis), which allowed the determination of this drug at concentrations below the detection limit.
Havana syndrome: a scoping review of the existing literature
Authors: Asadi-Pooya Ali A. 
Published: August 2022

Abstract
Since 2016, numerous American and Canadian diplomats and secret (intelligence) agents in Cuba, China, and other places in the world have experienced an abrupt onset of unusual clinical symptoms including, tinnitus, visual problems, vertigo, and cognitive difficulties, after they encountered strange sounds; this has been called “Havana syndrome” (HS). MEDLINE, Scopus, and Ovid databases from 2016 until 24 September 2021 were systematically searched for the related published manuscripts. The following search strategy was implemented: “Havana syndrome” OR “Neurological Symptoms and US Diplomats”. The primary search yielded 120 publications. Only five original studies and 18 non-original articles were considered to be relevant. While these studies provided a constellation of signs and symptoms for HS, none provided a good level of evidence. In conclusion, Havana syndrome is a nonspecific neurological illness with an unidentified causative factor(s), an acute phase of auditory-vestibular symptoms and a chronic phase of nonspecific neurobehavioral symptoms. This syndrome should be considered and investigated as a health concern, and not as a political issue.
Evaluation of hemolysis interference and possible protective effect of N-phenyl maleimide on the measurement of small peptides
Authors: Durmaz Mustafa , Erguder Imge 
Published: August 2022

Abstract

Objectives
This study aims to demonstrate that proteolytic enzymes released as a result of hemolysis decrease the small peptide hormones, whereas N-phenyl maleimide (NPM) can be used to prevent hemolysis interference.

Methods
The serum/plasma pools were prepared at two different concentrations and divided into two equal volumes. NPM solution was added to one sample. The erythrocyte package was washed five times and then centrifuged after each wash. Hemolysis was induced by the osmotic shock method upon adding distilled water. 100 µL of hemolysate stock solutions were added over 400 µL of serum/plasma pool. Repeated five times.

Results
Negative interference was demonstrated on ACTH at 200 hemolysis index (HI) for low concentration, at 100 HI and 200 HI for high concentration, and insulin at 100 HI and 200 HI for high concentration. Addition of NPM which inactivates protease enzymes prevented the reduction of ACTH and insulin. No interference was observed at C-peptide and IGF-1 concentration until 200 HI.

Conclusions
Hemolysis was detected to degrade ACTH and insulin, which demonstrated how important the effect of hemolysis can be utilized in deciding whether to accept or reject samples. The addition of NPM can increase accuracy in clinical decisions as well as treatment.
Prediction of Six Products from the Cucurbitaceae Family Using Visible/Near-Infrared Spectroscopic Data
Authors: Aydemir Onder 
Published: August 2022

Abstract
Recently, visible/near-infrared (Vis/NIR) spectroscopy has been used in the agricultural field, especially in the food industry, for monitoring food quality, postharvest handling of products, and identification of contamination on animal feeds, as well as prediction of a variety of fruits or vegetables. In this study, six products of the cucurbitaceous commodity, including zucchini, bitter gourd, ridge gourd, melon, chayote, and cucumber, were classified using Vis/NIR spectral data. After testing spectral data as feature, we also extracted statistical features and tested them with k-nearest neighbor, Bayes, decision tree, and support vector machines classifiers. We obtained a classification accuracy rate of 99 % on the test data by applying standard normal variate technique as a preprocessing stage. The results showed that cucurbitaceous commodity could be successfully classified using Vis/NIR spectra data.
СОЦИАЛЬНЫЕ РИСКИ ЭКОНОМИЧЕСКОГО ПОВЕДЕНИЯ СЕМЬИ В УСЛОВИЯХ ПАНДЕМИИ
Authors: Каменева Татьяна Николаевна , Селюков Максим Викторович , Шалыгина Наталья Петровна 
Published: August 2022

Целью исследования является изучение рисков реализации экономической функции современной семьи в условиях нестабильности общества.
Источники информации и методология исследования. При подготовке данной статьи были использованы результаты всероссийского социологического исследования методом онлайн-опроса «Отношение молодежи к здоровью в условиях новой коронавирусной инфекции» (руководитель — д. соц. н., профессор Ю. А. Зубок), регионального социологического исследования методом онлайн-опроса «Роль семьи в формировании отношения к здоровью» (руководитель — д. соц. н., доцент Т. Н. Каменева), регионального мониторингового исследования методом анкетирования «Трансформация семейно-брачных отношений в условиях социокультурных рисков», осуществленным в период 2014, 2017, 2020 гг. (руководитель — д. соц. н., доцент Т. Н. Каменева).
Для выделения рисков экономического поведения семьи в период пандемии COVID-19 был применен комплексный анализ полученных социологических данных.
Результаты исследования. Складывающаяся ситуация, обусловленная пандемией, поставила семью в новые непростые условия, существенным образом изменив уклад жизнедеятельности ее членов во всех сферах, но прежде всего повлияла на экономическое поведение. Влияние социальных рисков на экономическое поведение семьи в условиях пандемии достаточно противоречиво. Меры государственной поддержки позволили стабилизировать ситуацию с доходами населения. Вынужденная самоизоляция, страх потери работы, а, следовательно, и доходов повлияли на экономическое поведение семей. Результаты исследования позволили выявить новые «специфические» факторы социальных рисков, связанные с вынужденным дистанционным форматом работы и обучения и информационным давлением. Около 1/3 части респондентов высказали мнение, что их доходы снизились, а основные траты связаны с покупкой лекарств, медицинским обслуживанием, приобретением IT-техники, продуктов питания и первой необходимости, коммунальными расходами.
Перспективы исследования. Полученные результаты могут быть использованы в рамках курсов «Социология семьи» и «Финансовая социология».
ДЕНАЦИФИКАЦИЯ УКРАИНЫ: ПОЛИТИКО-ФИЛОСОФСКИЙ КОНТЕКСТ
Authors: Гурба Владимир Николаевич 
Published: August 2022

Целью статьи является анализ содержания и перспектив денацификации Украины как системного процесса «оздоровления» общества, государства и массового сознания на основе преодоления рецидивов нацизма и национализма, критики старых и новых мифов, связанных со становлением украинского государства и нации, а также преодоление культурной травмированности массового сознания под влиянием постмодернистского либерального дискурса декоммунизации и дерусификации украинского общества. На основе реализации методологического принципа единства исторического и логического в статье определяются концептуальные и социально-практические параметры денацификации. Делается вывод о том, что денацификация украинского общества является длительным процессом, связанным с результатами демилитаризации правовых и политических процедур, направленных на формирование ответственного гражданского общества, развития системы самоуправления, реформированием сферы медиа, культуры и образования.