bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic cardiovascular nursing care in Spanish primary care: A qualitative study
Authors: Lizcano‐Álvarez Angel , Esteban‐Hernández Jesús , Alameda‐Cuesta Almudena , Cid‐Expósito Gema , Palacios‐Ceña Domingo 
Published: December 2022

AbstractAimsWe aimed to investigate the perspective of primary care nurses on their role with patients who have chronic cardiovascular disease and to identify cultural elements shared by nurses caring for people with chronic cardiovascular disease. In primary care, the role of the nurse is essential to promote self‐efficacy in cardiovascular self‐care. Individuals with chronic cardiovascular disease need to integrate the disease into their life, together with the health recommendations for management and follow‐up.MethodsA qualitative, focused ethnographic study was conducted. Purposeful sampling was used to include nurses who were working in primary care during the study. Data collection took place between 20 January and 20 May 2014 and consisted of semi‐structured interviews. A thematic analysis was applied using the data.ResultsEleven participants were included. Cardiovascular care forces nurses to reflect on their identity and role in primary care. The relationship between the nurse and people with chronic cardiovascular disease is a complex process, which may cause nurses to feel a sense of failure and monotony in their work.ConclusionsOur findings may help to understand the role of the nurse and the care provided in patients with chronic cardiovascular disease.
Correlation between extended pelvic lymph node dissection and urinary incontinence at early phase after robot‐assisted radical prostatectomy
Authors: Lee Ken , Shiota Masaki , Takamatsu Dai , Ushijima Miho , Blas Leandro , Okabe Ayami , Kajioka Shunichi , Goto Shunsuke , Kinoshita Fumio , Matsumoto Takashi , Monji Keisuke , Kashiwagi Eiji , Inokuchi Junichi , Oda Yoshinao , Eto Masatoshi 
Published: December 2022

ObjectivesTo investigate the impact of extended pelvic lymph node dissection (ePLND) on urinary incontinence (UI) at early post‐surgery robot‐assisted radical prostatectomy (RARP).MethodsPatients who underwent RARP without cavernous nerve sparing were included between 2014 and 2019. Patient data were obtained prospectively. The associations between ePLND and postoperative urinary continence were defined as a maximum of one daily pad use. International prostate symptom score (IPSS) was examined. Expression of synaptophysin and tyrosine hydroxylase (TH) in perilymph node adipose tissue (PLA) was evaluated by immunohistochemistry.ResultsIn total, 186 and 163 patients underwent RARP with and without ePLND. Urinary continence rate at 1 month postoperatively among patients with ePLND was lower than those without ePLND (24.1% vs. 35.1%, p < 0.05), however, not significantly different at 3, 6, and 12 months after RARP (57.4 vs. 62.6%, 73.1 vs. 74.2%, and 83.0 vs. 81.2%, respectively). Total and voiding plus postvoiding IPSS scores at 1 month were higher in patients with ePLND than in those without ePLND (14.5 ± 0.5 vs. 13.6 ± 0.6, 7.0 ± 0.3 vs. 6.2 ± 0.4, respectively, p < 0.05). In univariate and multivariate analyses, larger prostate volume and ePLND were factors associated with an increased UI rate. Among patients who underwent ePLND, synaptophysin and TH‐positive nerve fibers were detected in PLA.ConclusionsDetection of synaptophysin and TH‐immunopositive nerves suggested denervation of sympathetic and peripheral nerves caused by ePLND might be associated with a higher UI rate and poor urinary symptoms at an early stage after RARP.
Employment law and its contribution to labour market segmentation in Latin America
Authors: BENSUSÁN AREOUS Graciela 
Published: December 2022

AbstractThis article examines legal segmentation in five Latin American countries (Argentina, Brazil, Chile, Mexico and Uruguay) by drawing on the employment regulation typology developed by Dingeldey et al. (2022), based on three functions – standard‐setting, privileging and equalizing. The author distinguishes between three factors of inequality and precarity: lack of coverage (namely of self‐employed workers), discrimination and the circumvention of standards. Lack of enforcement, together with an unfavourable economic environment, results in informality. The analysis identifies different forms and levels of protection under standard and non‐standard employment, as well as compensatory rules and other regulations seeking to eliminate inequality.
Outcomes of transvenous lead extraction of very old leads using bidirectional rotational mechanical sheaths: Results of a multicentre study
Authors: Migliore Federico , Pittorru Raimondo , Dall'Aglio Pietro Bernardo , De Lazzari Manuel , Rovaris Giovanni , Piazzi Elena , Dentico Alessia , Ferrieri Alessandra , D'Angelo Giuseppe , Marzi Alessandra , Sawaf Basma El , Bertaglia Emanuele , Iliceto Sabino , Gerosa Gino , Tarzia Vincenzo , Carretta Domenico , Mazzone Patrizio 
Published: December 2022

AbstractIntroductionLead dwell time >10 years is a recognized predictor for transvenous lead extraction (TLE) failure and complications. Data on the efficacy and safety of TLE using the bidirectional rotational mechanical sheaths in patients with very old leads are lacking. In this multicenter study, we reported the outcomes of transvenous rotational mechanical lead extraction in patients with leads implanted for ≥10 years.MethodsA total of 441 leads (median: 159 months [135–197]; range: 120–487) in 189 consecutive patients were removed with the Evolution RL sheaths (Cook Medical, Bloomingtom, IN, USA) and mechanical ancillary tools supporting the procedures.ResultsThe main indication for TLE was infection in 74% of cases. Complete procedural success rate, clinical success rate, per lead were 94.8% and 98.2%, respectively. Failure of lead extraction was seen in 1.8% of leads. The additional use of a snare via the femoral approach was required in 9% of patients. Lead dwell time was the only predictor of incomplete led removal (odds ratio: 1.009; 95% confidence interval [CI]: 1.003–1.014; p = .002). Four major complication (2%) were encountered. During a mean time follow‐up of 31 ± 27 months, 21 patients (11%) died. No procedure‐related mortality occurred. Predictors of mortality included severe left ventricular systolic dysfunction (hazard ratio [HR]: 8.06; 95% CI: 2.99–21.73; p = .001), TLE for infection (HR: 8.0; 95% CI: 1.04–62.5; p = .045), diabetes (HR: 3.7; 95% CI: 1.48–9.5; p = .005), and previous systemic infection (HR: 3.1; 95% CI: 1.17–8.24; p = .022). Incomplete lead removal or failure lead extraction did not impact on survival during follow‐up.ConclusionOur findings demonstrated that the use of bidirectional rotational TLE mechanical sheaths combined with different mechanical tools and femoral approach allows reasonable success and safety in patients with very old leads at experienced specialized centers.
Management and treatment outcome of DRESS patients in Europe: An international multicentre retrospective study of 141 cases
Authors: Kridin Khalaf , Brüggen Marie‐Charlotte , Walsh Sarah , Bensaid Benoit , Ranki Annamari , Oppel Eva , Meyersburg Damian , Chua Ser‐Ling , Seeli Corsin , Sandberg Heidi , French Lars E. , Vorobyev Artem , Ingen‐Housz‐Oro Saskia 
Published: December 2022

AbstractBackgroundDrug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially fatal drug hypersensitivity reaction.ObjectiveTo explore treatment approaches across Europe and their impact on the disease course, as well as prognostic factors and culprit drugs.MethodsIn this retrospective European multicentric study, we included patients with probable or certain DRESS (RegiSCAR score ≥ 4) between January 2016 and December 2020. Independent associations between clinical parameters and the risk of intensive care unit admission and mortality at three months were assessed using a multivariable‐adjusted logistic regression model.ResultsA total of 141 patients from 8 tertiary centres were included. Morbilliform exanthem was the most frequent cutaneous manifestation (78.0%). The mean affected body surface area (BSA) was 67%, 42% of the patients presented with erythroderma, and 24.8% had mucosal involvement. Based on systemic involvement, 31.9% of the patients had a severe DRESS. Anticonvulsants (24.1%) and sulphonamides (22.0%) were the most frequent causative agents. In all, 73% of the patients were treated with systemic glucocorticoids, and 25.5% received topical corticosteroids as monotherapy. Few patients received antiviral drugs or anti‐IL5. No patients received intravenous immunoglobulins. The overall mortality was 7.1%. Independent predictors of mortality were older age (≥57.0 years; fully adjusted OR, 9.80; 95% CI, 1.20–79.93; p = 0.033), kidney involvement (fully adjusted OR, 4.70; 95% CI, 1.00–24.12; p = 0.049), and admission in intensive care unit (fully adjusted OR, 8.12; 95% CI, 1.90–34.67; p = 0.005). Relapse of DRESS and delayed autoimmune sequelae occurred in 8.5% and 12.1% of patients, respectively.ConclusionsThis study underlines the need for diagnostic and prognostic scores/markers as well as for prospective clinical trials of drugs with the potential to reduce mortality and complications of DRESS.
Systematic review of newer agents for the management of alopecia areata in adults: Janus kinase inhibitors, biologics and phosphodiesterase‐4 inhibitors
Authors: Gupta Aditya K. , Wang Tong , Polla Ravi Shruthi , Bamimore Mary A. , Piguet Vincent , Tosti Antonella 
Published: December 2022

AbstractManagement options for moderate‐to‐severe alopecia areata (AA) are limited owing to a lack of safe and effective treatments suitable for long‐term use. However, newer agents have the potential to induce and maintain hair regrowth in patients with a better side‐effects profile compared to systemic steroids or conventional systemic agents. In this article, we conducted a systematic review of newer agents, including Janus kinase (JAK) inhibitors, biologics and phosphodiesterase‐4 (PDE‐4) inhibitors, for the treatment of AA in adult patients evaluated in randomized controlled trials (RCTs) using the Severity of Alopecia Tool score. A literature search was performed on PubMed and ClinicalTrials.gov, which identified 106 items with 12 RCTs eligible for review. Information regarding the treatment regimen, duration, endpoints, efficacy and adverse events were extracted; product monograph information was also summarized for approved agents with or without indications for AA. Overall, current data suggest the oral JAK inhibitors (baricitinib, ritlecitinib, deuruxolitinib, brepocitinib) as a promising new class of agents that can induce significant hair regrowth, with mild to moderate adverse effects. Baricitinib recently received US FDA approval for the treatment of severe AA, while ritlecitinib and deuruxolitinib have received the breakthrough therapy designation for AA. In contrast, PDE‐4 inhibitors (apremilast) and the biologics (dupilumab, secukinumab and aldesleukin) appear to have limited efficacy thus far. Results from ongoing and future long‐term studies could shed light on the utility of the newer agents in altering the progression of AA.
Patient‐reported outcome measures focusing on the esthetics of implant‐compared to tooth‐supported single crowns—A systematic review and meta‐analysis
Authors: Wittneben Julia‐Gabriela , Yilmaz Burak , Wismeijer Daniel , Shahdad Shakeel , Brägger Urs , Abou‐Ayash Samir 
Published: December 2022

AbstractObjectivesTo report a summary of published patient‐reported esthetic outcome measures (PROMs) of implant‐supported single crowns (SCs) compared with those of tooth‐supported SCs.Materials and MethodsCochrane, Medline (PubMed), and EMBASE database search was performed by three reviewers on reports with patient‐reported esthetic outcomes of tooth‐ and implant‐supported SCs. Clinical studies with at least 12 months of mean follow‐up period and a minimum of 10 patients, and English, French, or German reports were included. To compare the subgroups, for aggregate‐level data, random‐effects meta‐regression was used.ResultsTwo thousand fifteen titles were identified (initial search) and screened independently concluding 53 full‐text articles to include in data extraction. Twenty‐two studies with 29 study cohorts were included. Patients were satisfied with the esthetics of implant‐ and tooth‐ supported crowns Mean visual analogue scale (VAS) value from the PROMs data of 1270 implant‐supported SCs evaluated by 1051 patients was 89.6% (80.0%–94.1%). The mean VAS value of patients (n = 201), who evaluated the esthetic outcome of 486 tooth‐supported SCs was 94.4% (92.3%–96.0%). VAS scores of patients regarding their perception of esthetics did not show any difference among different crown materials or type of implant used. The patients' perception of esthetics focusing on SC had a tendency to be higher when the crowns were supported by teeth, however, no statistical difference was found when compared with implant‐supported crowns (p = 0.067).ConclusionsPatient perception of esthetics in SCs was not affected by the type of support, crown material, implant, and presence of provisional crown for both implant‐ and tooth‐supported SCs.Clinical SignificanceDespite that patient's expectations are increasing overall Patients are satisfied with with esthetic outcome of implant‐ and tooth‐supported crowns.
Efficient genotype‐independent cotton genetic transformation and genome editing
Authors: Ge Xiaoyang , Xu Jieting , Yang Zhaoen , Yang Xiaofeng , Wang Ye , Chen Yanli , Wang Peng , Li Fuguang 
Published: December 2022

ABSTRACTCotton (Gossypium spp.) is one of the most important fiber crops worldwide. In the last two decades, transgenesis and genome editing have played important roles in cotton improvement. However, genotype dependence is one of the key bottlenecks in generating transgenic and gene‐edited cotton plants through either particle bombardment or Agrobacterium‐mediated transformation. Here, we developed a shoot apical meristem (SAM) cell‐mediated transformation system (SAMT) that allowed the transformation of recalcitrant cotton genotypes including widely grown upland cotton (Gossypium hirsutum), Sea island cotton (Gossypium barbadense), and Asiatic cotton (Gossypium arboreum). Through SAMT, we successfully introduced two foreign genes, GFP and RUBY, into SAM cells of some recalcitrant cotton genotypes. Within 2–3 months, transgenic adventitious shoots generated from the axillary meristem zone could be recovered and grown into whole cotton plants. The GFP fluorescent signal and betalain accumulation could be observed in various tissues in GFP‐ and RUBY‐positive plants, as well as in their progenies, indicating that the transgenes were stably integrated into the genome and transmitted to the next generation. Furthermore, using SAMT, we successfully generated edited cotton plants with inheritable targeted mutagenesis in the GhPGF and GhRCD1 genes through CRISPR/Cas9‐mediated genome editing. In summary, the established SAMT transformation system here in this study bypasses the embryogenesis process during tissue culture in a conventional transformation procedure and significantly accelerates the generation of transgenic and gene‐edited plants for genetic improvement of recalcitrant cotton varieties.
Factors related to indecisive attitudes toward non‐invasive prenatal testing among women of reproductive age in Japan
Authors: Katada Chihiro , Ohashi Kazutomo , Okada Kimie , Sawai Hideaki 
Published: December 2022

AbstractAimThis study aimed to investigate the factors related to indecisive attitudes toward noninvasive prenatal testing (NIPT) among nonpregnant women of reproductive age.MethodsWe conducted an online survey involving nonpregnant Japanese women aged 20–49 years. The questionnaires consisted of a hypothetical question about whether they would decide to undergo NIPT if they were to become pregnant, and responses with “unsure” were defined as indecisive attitudes.ResultsOf 1250 participants, 412 (33%) held indecisive attitudes on whether to undergo NIPT. Multivariable logistic regression analysis demonstrated indecisive attitudes were related to a low level of knowledge about prenatal testing (adjusted odds ratio [AOR] 3.89) and preferences for family‐driven decisions (AOR 1.44) instead of provider‐driven.ConclusionEven though the NIPT is widespread, many nonpregnant women of reproductive age are unable to decide whether to undergo the NIPT or not. Hence, indecisive women toward NIPT require adequate information and communication about future NIPT among their families prior to conception. Therefore, preconception support of providing adequate information about testing and facilitating communication regarding future NIPT among women and their family members may help indecisive women make autonomous decisions on NIPT.
Association between masticatory dysfunction and gastroesophageal reflux disease: A population‐based study in the elderly
Authors: Kuze Luana Soares , Fornari Fernando , Collares Kauê , Della Bona Alvaro 
Published: December 2022

AbstractBackgroundCaries and periodontal disease may cause tooth losses and chewing difficulty, especially in the elderly. Ingesting poorly chewed food may delay gastric emptying and favour the development of gastroesophageal reflux disease (GERD).ObjectiveThis study investigated the association between masticatory dysfunction and GERD in the elderly from a rural area in southern Brazil.MethodsThis census invited all 489 elderly from a city to participate. The study used a GERD symptoms questionnaire, followed by an oral examination. Masticatory dysfunction was analysed based on the chewing difficulty for some food groups. Tooth loss and chewing self‐perception were also considered as exposure variables. Poisson regression determined the association among variables by calculating the prevalence ratio [PR (95% confidence interval)].ResultsThe response rate was 93.1% (n = 455, average age of 70.9 years, 50.5% men). The prevalence of GERD in this population was 36.9%. GERD was associated with chewing difficulty for vegetables (PR = 1.54), meats (PR = 1.34) and cereals (PR = 1.43) but not with poor chewing self‐perception (PR = 0.80) and tooth loss (PR = 1.22). GERD was also associated with xerostomia (PR = 1.63) and the female gender (PR = 1.35).ConclusionElderly people from a rural area with a reduced number of teeth present chewing difficulty and a high prevalence of GERD, indicating an association between GERD and masticatory dysfunction.
Leadership in the eye of the beholder: Follower self‐esteem is associated with divergent perceptions of leadership ability for dominant and prestigious leaders
Authors: Mercadante Eric J. , Heine Steven J. , Aquino Karl 
Published: December 2022

AbstractObjectiveDrawing from dual‐strategies theory, leader‐member exchange theory, and several theories of self‐esteem, we develop and test hypotheses about how followers' self‐esteem predicts their perceptions of dominant and prestigious leaders' leadership ability.MethodAcross four studies (N = 1568), we tested the association between self‐esteem and perceptions of leadership ability for dominant and prestigious leaders.ResultsIndividuals with high self‐esteem perceived greater leadership ability in prestigious leaders than did those with low self‐esteem and individuals with low self‐esteem perceived greater leadership ability in dominant leaders than did those with high self‐esteem. These results emerged across ratings of leaders from hypothetical vignettes (Studies 1 and 4), abstract beliefs about what constitutes good leadership (Study 1), past personal experiences with leaders (Study 2) and clips of leaders from reality television (Study 3). In Study 4, we also tested potential mechanisms. Compared with followers with low self‐esteem, followers with high self‐esteem found prestigious leaders more trustworthy, and they anticipated feeling inauthentic around a dominant leader.ConclusionsSelf‐esteem is reliably and robustly related to perceived leadership ability of dominant and prestigious leaders, and these differences might stem from differences in trust in prestigious leaders and anticipated authenticity around dominant leaders.
A prototype regional stock‐flow consistent model
Authors: Zezza Francesco , Zezza Gennaro 
Published: December 2022

AbstractWhen considering a regional context, most adjusting mechanisms at work in open economy Stock‐Flow Consistent models—such as exchange rate movements, or changes in interest on public debt—are not present, as they are in control of “external” authorities. So, how does a regional system with “current account” imbalances adjust? To answer this question, we adapt the framework suggested in Godley‐Lavoie (2007a) to consider two regions that share the same monetary, fiscal, and exchange rate policies. The model—loosely calibrated over Italian data, with the introduction of a fragmented labour market—replicates some key features of the Italian economy, and sheds light on the interactions between financial and real markets in regional economies.
Sanctions, Deterrence, Regime Change: A New Look at US‐Iran Relations
Authors: Monshipouri Mahmood , Boggio Giorgio Davide 
Published: December 2022

AbstractOver the past four decades, the United States has managed its foreign policy toward Iran through a combination of sanctions, diplomatic incentives, and threats of military intervention. This approach has come down to two choices: war or sanctions. Clearly, sanctions have deprived Iran of access to foreign investment in its oil and energy sectors, caused many oil companies to withdraw from Iran, and dramatically reduced Iran's oil revenue. However, sanctions have had a more damaging effect on ordinary people than on the targeted leaders of the country. Sanctions have neither altered Iran's foreign‐policy conduct nor led to regime change. Before Iran is completely pushed into the arms of China and Russia, the third option—diplomacy with a potentially new regime—deserves attention. The next few years will likely answer the question of how these difficult and explosive US‐Iranian relations will be managed: through diplomacy, ongoing sanctions, or by escalatory deterrence.
Lp‐pPG‐611.1‐LPS as an immune enhancer provides effective protection against Aeromonas veronii infection in Carassius auratus
Authors: Zhao Tong , Yang Bintong , Li Hongjin , Hao Zhipeng , Cong Wei , Kang Yuanhuan 
Published: December 2022

AbstractAeromonas veronii (A. veronii) is an important zoonotic pathogen that causes substantial economic losses in aquaculture. In this study, we aimed to develop a safe and effective immune enhancer to protect Carassius auratus (C. auratus) from A. veronii infections. With recognized safety, lactic acid bacteria are used as antigen delivery vehicles to present antigens. Lipopolysaccharide (LPS), a protective antigen, induces immune responses in animals. Therefore, we created recombinant Lactobacillus plantarum (L. plantarum) with surface‐displayed LPS of A. veronii TH0426 and tested its effects on immune responses in C. auratus. The results showed that recombinant L. plantarum Lp‐pPG‐611.1‐LPS, as an immune enhancer, could improve the innate and adaptive immune responses of C. auratus when it was added to the diet of C. auratus. The challenge test showed that the survival rate of C. auratus fed with L. plantarum Lp‐pPG‐611.1‐LPS was higher than that of the control groups, indicating that the recombinant L. plantarum Lp‐pPG‐611.1‐LPS increased the resistance of C. auratus to A. veronii infection. The present results provide a theoretical basis for the development of recombinant L. plantarum Lp‐pPG‐611.1‐LPS as an immune enhancer in aquaculture.