bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Surface Irrigation Potential Availability Using Gis in Gilgel Abbay Catchment; Ethiopia
Authors: Sintayehu Gashaw , Temesgen Edmealem , Akili Destaw 
Published: May 2022

Abstract
Irrigation is an important investment for improving rural income through increased
agricultural production. The expansion of irrigation and effectively manage agricultural water holds significant potential to enhance productivity and reduce vulnerability to the climactic
volatility in any country. Investigation of available water resources and potentially irrigable land is essential for the development of irrigated agriculture. This study was concerned with the assessment of surface irrigation potential availability in the Gilgel Abay watershed by implementing Arc GIS 10.1. Assessment of land suitability for irrigation is essential for the long production of crops and food security of the ever-growing population, as well as for the efficient use of limited physical land resources in the studied area. This research focuses on the possibilities for catchment surface irrigation and a water-saving sowing time scenario. The physical and chemical properties of the soil, slope, LULC, distance from water sources (Proximity to water), and surface water resource availability were all considered while determining land suitability for surface irrigation. According to the results of the land suitability evaluation ratings based on quantitative and qualitative land suitability for surface irrigation, 22.59 percent (86,747.19 ha) of lands in the research region were in the high to marginally suitable classes, while 77.41 percent were in the non-suitable class (297,252.4 ha). For November, December, January, and February sowing time scenarios, total irrigation water demand is 5,927.5Mm3, 370.2 Mm3, 455.4 Mm3, and 506.2 Mm3 respectively accordingly to irrigate 86961.24ha of irrigable land for 10 selected and dominating crops. The most favorable sowing starting month, according to sowing time scenarios, is in December, in order to save water or use less water to irrigate all available irrigable land and to fulfill all selected and dominating crops in the research area. Therefore, as a result, this research will assist all participants in making irrigation investment decisions and identifying long-term irrigation investment prospects in the study area.
The Quantitative Evaluation of Retinal Layers After Resolution of Subretinal Fluid in Acute Central Serous Chorioretinopathy
Authors: Dursun Erdem , Dursun Gamze Akyuz 
Published: May 2022

Abstract
Purpose: To evaluate the average retinal layer thicknesses in eyes with unilateral acute central serous chorioretinopathy (CSC) (with subretinal fluid (SRF)) and after complete resolution of SRF in these eyes and to compare the results with those obtained in healthy eyes.Methods: Fifty-four eyes of 27 patients with unilateral acute CSC who had complete resolution of SRF and 25 eyes of 25 healthy control subjects enrolled in this retrospective study. The average thicknesses of the retinal layers were measured by segmentation analysis of optical coherence tomography at baseline and 6 months after complete resolution of SRF.Results: The mean outer nuclear layer (ONL) thickness was significantly lower in eyes with CSC than in fellow eyes (p<0.001). The mean ONL thickness was increased after resolution of SRF, but still low compared to unaffected fellow eye and the increment was not statistically significant (p>0.05). There were significant correlations between visual acuity and ONL thicknesses at baseline and 6 months after complete resolution of SRF (p<0.001, r=-0.810; p<0.001, r=-0.705, respectively).Conclusion: ONL thickness is thinned in cases with acute CSC, and although there is some increment in ONL thickness 6 months after complete resolution of SRF, it is still thinner compared to unaffected fellow eyes.
A hybrid Latent Dirichlet Allocation - BERT approach for topic discovery of market places
Authors: Bouabdallaoui Ibrahim , Guerouate Fatima , Bouhaddour Samya , Saadi Chaimae , Sbihi Mohamed 
Published: May 2022

Abstract
The tourism industry is now intimately linked to the web, as It was one of the first industries to fit on digital transformation. The tourist is more autonomous in organizing and preparing his trip, and the possibilities of leaving at competitive prices are numerous. New technologies have an impact on tourism and it is now necessary to think about communication and marketing accordingly. Market places in Morocco are reached by millions of tourists each year. Tourists share their experiences in social medias to encourage or discourage other tourists who are interested in visiting such places. The main goal of this work is to propose a hybrid architecture based on Latent Dirichlet Allocation (LDA) and Bidirectional Encoder Representations from Transformers (BERT) with a latent space representation technique to perform topic modeling and have as a result an idea of each tourist's review and particularly what he thinks about a specific market place in Morocco.
Multi-organs toxicities induced by anti-tubercular drugs: A preclinical experimental study
Authors: Ahmed Akheruz Zaman , Bhat Nandini Prashanth , Kalthur Sneha Guruprasad 
Published: May 2022

Abstract
This study was aimed to observe the multiple organ toxicities induced by different anti-tubercular drug resistant groups like isoniazid resistance, rifampicin resistance, multidrug resistance including drug susceptible anti-tubercular drugs and their time of recovery from the toxicities induced by these drugs. Wistar Albino mice were treated with drug susceptible anti-tubercular drug (Isoniazid, Rifampicin, Ethambutol & Pyrazinamide), Isoniazid resistance anti-tubercular drugs (Kanamycin, Levofloxacin, Rifampicin, Pyrazinamide & Ethambutol), Rifampicin resistance anti-tubercular drugs (Kanamycin, Levofloxacin, Ethionamide, Cycloserine, Isoniazid, Pyrazinamide & Ethambutol), Multidrug resistance anti-tubercular drug (Kanamycin, Levofloxacin, Ethionamide, Cycloserine, Pyrazinamide & Ethambutol). Animals were sacrificed after giving two weeks recovery gap from the last drug treatment. To understand the late effects, mice were sacrificed after giving two months recovery gap from the last drug treatment. Histopathology of internal organs was done by H & E and PAS. Bone marrow cells were stained with Acridine Orange dye to detect micronucleus and apoptotic cells. Expression of γ-H2AX in bone marrow cells were done by immunohistochemistry. In liver moderate to severe type of toxicities were observed in all groups in the form of nuclear alteration, sinusoidal dilation, vacuolization, necrosis, WBC infiltration. In kidney we had observed mesangial cell proliferation, vacuolization, WBC infiltration, dilation of Bowman’s space. The severity of toxicity was more at short term recovery group than long term recovery groups. Drug susceptible anti-tubercular drugs (INH, RIF, and EMB & PZA) had shown more toxic in compared to other anti-tubercular drugs.
Assessment of the Informed Consent Process in the Provision of Dental Care in Mulagohospital, Uganda
Authors: Nono- David , Mapley Edward , Rwenyonyi Charles Mugisha , Okullo Isaac 
Published: May 2022

Abstract
Background: Informed consent is grounded in the principle of autonomy and represents patients’ rights to participate in clinical decisions regarding their treatment. It is equally an ethical and legal requirement in dental care. The dental practitioner must offer appropriate information about all aspects of the treatment and ensure that a patient understands and makes an informed decision. There is limited literature on informed consent for dental care in Uganda. The aim of the study was to assess patients’ comprehension of the informed consent process and dental practitioners’ practices in obtaining informed consent.Methods: This was a cross-sectional descriptive study conducted in the Dental Outpatient Department of Mulago Hospital. Two separate questionnaires were employed to collect data from dental patients and dental practitioners, respectively. Data were entered into Epi-data, coded and imported into STATA 14 for statistical analysis.Results: Overall, the level of patients’ comprehension of the informed consent process was 91.1%, with 96.3% who felt the dental practitioners satisfactorily explained to them the treatment received and, 65.1%understood very well the information given to them. About 93.5% of the patients confessed that they were given other options of treatment while 98.5% consented before the dental practitioners started treatment. Most (94.7%) dental practitioners followed good clinical practices in obtaining informed consent and 98.7% gave information before initiation of treatment while 85.3% obtained consent from patients before starting any procedures. However, only 4 (5.3%) of the dental practitioners obtained written informed consent from patients. Conclusion: There is a need to devise ways of improving patients' understanding of the treatment information given to them to support them make better and informed decisions regarding their care. Dental practitioners need to put more emphasis on the use of written consent in dental care because documentation helps in providing accountability and protects dentists from medical litigation in case the patients were to sue them for any treatment-related complications.
Application of Analytic Hierarchy Process: Key Factors of an Environment-related Gender Assessment Project
Authors: Chen You-Ning , Tseng Chao-Heng , Hsieh Ming-Lun 
Published: May 2022

Abstract
Gender issues have become a sustainable development goal under the UN auspices. Gender assessment projects are more likely to face gender differences and create corresponding policies, legislations, or treatments. Shortcomings in gender assessment projects include the impact of environmental issues on gender studies. Recently, natural disasters and air pollution incidents have been frequent. The environmental field has gradually focused on gender and environmental issues. However, domestic and foreign environment-related gender assessment projects primarily use organisational gender structure, gender income, and political participation rates as the primary assessment items. They lack environment-related gender assessment projects. This study collected 100 related studies, which were filtered into 89 articles, comprehensively integrating four assessment dimensions, eight perspectives, and 16 assessment projects. Further, through a questionnaire survey and analytic hierarchy process AHP) analysis, the study determined the key factors of an environmental-related gender assessment project. The key factors were working environments and climate change, especially related to occupational disease and high-temperature disease, emphasising mortality and prevalence rates. Therefore, gender assessment projects should prioritise establishing assessment projects and statistical indicators of the working environment and climate change perspectives and implement them in corresponding gender and environmental policies, legislations, or disposals.
Insect-mediated pollination improves fruit quality of strawberries in an urban environment
Authors: Blareau Elsa , Sy Pauline , Daoud Karim , Requier Fabrice 
Published: May 2022

Abstract
Pollination services provided by a diversity of pollinators are critical in agriculture since they enhance the yield of many crops. However, few studies have assessed pollination services in urban agricultural systems. We performed flower-visitor observations and pollination experiments on strawberries, Fragaria × ananassa, in an urban area of Paris, France, in order to assess the effects of (i) insect-mediated pollination service and (ii) potential pollination deficit on fruit set and fruit quality (size, weight, malformation and seed set). Flower-visitor observations revealed that the pollinator community was solely comprised of unmanaged pollinators, despite the presence of apiaries in the surrounding landscape. Based on the pollination experiments, we found that the pollination service mediated by wild insects improved fruit size as a qualitative value of production, but not fruit set. We also found no evidence for pollination deficit in our urban environment. These results suggest that the local community of wild urban pollinators is able to support strawberry crop production, and thus plays an important role in providing high quality, local and sustainable crops in urban areas.
Epidemiology and Survival Analysis of Patients with Brainstem Cavernous Hemangioma: A Population-Based Study Using the SEER Database
Authors: Zhan Zhixin , He Ding , Yang Zedi , Liu Ziqiang , Chen Yong , Huang Haiyan 
Published: May 2022

Abstract
This population-based study determined the epidemiology, incidence, and outcomes of brainstem cavernous hemangioma. Data on patients with brainstem cavernous hemangioma were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Descriptive analysis assessed the distribution and tumor-related characteristics of patients with brainstem cavernous hemangioma. The Kaplan–Meier method and Cox proportional hazard model were used to analyzed the possible prognostic indicators. The age-adjusted incidence rate between 2000 and 2019 was 0.0236 cases per 100,000 person-years. A total of 283 cases of brainstem cavernous hemangioma were identified between 2000 and 2019. The median patient age was 45 years (range, 0–87 years). Most patients were diagnosed between 40–44 and 55–59 years of age. Middle-aged adults (40–59 years old) accounted for 41.34% of all patients. White patients accounted for 82.6% of all patients. All patients diagnosed with brainstem cavernous hemangioma had benign lesions. Surgery was performed in 105 (37.1%) cases, radiation therapy in 5 (1.7%) cases, and chemotherapy in 1(0.4%) case. The median survival time was 71 months (range: 0–189 months). Age at diagnosis and surgery were two strong factors affecting occurrence and prognosis. Incidence did not differ between sexes and was higher in white patients. Tumor size had little impact on early prognosis; however, for late prognosis, smaller tumors (< 3 cm) had a better prognosis. No significant differences were observed in the outcomes between surgery and conservative treatment. We suggest that more attention should be paid to the treatment of patients with brainstem cavernous hemangioma.
Significance of postoperative serum carcinoembryonic antigen combined with tumor deposition in Stage II-III Colon Cancer Patients: a retrospective multicenter cohort study
Authors: Pu Hongjiang , Pang Xiaolin , Chen Yaxue , Ma Jianguo , Wu Runhong , Li Liyan , Liu Lizhu , You Ruimin , Fu Jiangping , Dong Xingxiang , Xiong Qiuxia 
Published: May 2022

Abstract
Purpose: This study aimed to investigate postoperative CEA combined with tumor deposition for risk stratification of postoperative recurrence of stage II-III colon cancer.Methods: A retrospective analysis of 761 patients who underwent radical surgery for stage II-III colon cancer from April 2008 to January 2019. Patients were grouped into 3 cohorts: normal postoperative CEA without tumor deposits（TD）, normal postoperative CEA with TD, and elevated postoperative CEA. Cox proportional hazards regression model was used to analyze the independent recurrence prognostic factors of patients with recurrence-free survival (RFS). The Kaplan-Meier method was used to draw the patient's RFS curve.Results: The median follow-up period of all patients was 49.73 months. A total of 761 patients (452 [59.4%] male; median [IQR] age, 69 [50-67] years) were identified. The 3-year RFS of 60 patients with normal postoperative CEA and positive TD was 51.1% (95% CI, 39.8%-65.5%), and the 3-year RFS of 103 patients with elevated postoperative CEA was 47.7% (95% CI, 38.5%-58.3%). (Patients with normal postoperative CEA and positive TD vs Patients with elevated postoperative CEA: HR, 1.04; 95% CI, 0.67-1.60; P = 0.877). Multivariate analysis of the COX proportional hazards model showed that normal postoperative CEA with TD (HR, 2.0; 95% CI, 1.1-3.5) is independently associated with shorter RFS.Conclusion: Patients with normal postoperative CEA still have a higher risk of recurrence if combined with tumor deposits. It is necessary to incorporate postoperative CEA and tumor deposition into high-risk factors for postoperative recurrence of colon cancer for management.
Genetic predisposition and cardiovascular risk factors: an unusual case of aortic regurgitation and LVOT obstruction
Authors: Balducci Anna , Molisana Michela , Palleri Daniela , Ciuca Cristina , Bartolacelli Ylenia , Careddu Lucio , Angeli Emanuela , Donti Andrea , Gargiulo Gaetano Domenico 
Published: May 2022

Abstract
This case describes a peculiar aetiology of severe aortic regurgitation and LVOT obstruction in a young adult with bilateral congenital cataract and uncontrolled hypertension, who presented with heart failure and was found to suffer from aortic valve degeneration with fibromuscular metaplasia and cusp delamination.
Theoretical derivation and clinical validation of the resolution limit of human eye to spherical lens change：A Self-controlled Study
Authors: Yi Zhen , Jie Gao , Kai Cao , Shen Jing , wei Zhang , Yun Dai 
Published: May 2022

Abstract
Purpose: The aim of this study was to deduce theoretically and verify the resolution limit of human eye to spherical lens change for more reasonable design of the trial lenses. Methods: A total of 119 normal subjects with different myopia (not more than -6D) were included . First, the resolution limit of discernible change in spherical power was derived based on the optical model. Then, the subjects were observed to see if they could perceive the changes in spherical power as per the resolution limit and compare the difference in the best corrected visual acuity obtained with the resolution limit and interval of 0.25D. Results: Assuming that the cone cell diameter is 3 μm and the pupil diameter of 4 mm, the theoretically resolution limit was 0.05D. When the diopter of spherical power was increased, the ratios of ability to perceive 0.05D spherical lens change were 98.3% and 96.7% in right and left eyes. When the diopter of spherical power was decreased, the ratios of ability to perceive 0.05D spherical lens change were 78.9% and 83.2% in right and left eyes. The best corrected visual acuity obtained with the 0.05 D interval trial lens was significantly better than in the 0.25 D interval on both eyes (Right eye -0.04±0.07 vs -0.02±0.06, p<0.001; Left eye -0.07±0.06 vs -0.04±0.06, t=8.825, p <0.001). Conclusion: The resolution limit of human eye to spherical lens change was about 0.05D and the better corrected visual acuity can be obtained by adjusting the spherical power at an interval of 0.05D. Trial registration number: ChiCTR2100047074
Application of a hybrid model based on GA–ELMAN neural networks and VMD double processing in water level prediction
Authors: Xing Wen Yan , Bai Yu Long , Ding Lin , Yu Qing He , Song Wei 
Published: May 2022

Abstract
Accurate water level prediction is of great importance for water infrastructures such as dams, embankments, and agriculture. However, the water level has nonlinear characteristics, which make it very challenging to accurately predict the water level. This study proposes a combined model based on variational mode decomposition (VMD), a genetic algorithm–the ELMAN neural network–VMD–the autoregressive integrated moving average (ARIMA) model (GA–ELMAN–VMD–ARIMA). Firstly, VMD preprocesses the original water level and predicts each subsequence with the GA–ELMAN model. Then the error sequence is decomposed by VMD and predicted by the ARIMA model. Finally, the predicted water level is corrected. Using three groups of data from different sites, 10 models are established to compare the performance of the model. The results show that the combination of the VMD algorithm and the GA–ELMAN model can improve the performance of prediction on datasets. In addition, it also shows that the VMD double processing can greatly improve the prediction accuracy.
Mechanistic Involvement of Inflammation in Bortezomib-induced Peripheral
Neuropathy
Authors: Gupta Pooja , Goel Lavisha , Pahuja Monika 
Published: May 2022

Aim:
To establish the role of inflammation in bortezomib induced peripheral neuropathy (BIPN).

Background:
Peripheral neuropathy is the dose-limiting toxicity of bortezomib which can lead to discontinuation of the treatment. There are multiple mechanisms involved in the disposition of BIPN. However, the role of inflammatory mediators is still under investigation. The complete understanding of inflammatory markers in relation to BIPN can lead to the development of effective therapy for prophylaxis and treatment of peripheral neuropathy.

Objective:
Based on the available data, postulate the role of inflammatory mediators in the development of peripheral neuropathy due to bortezomib.

Method:
The “Pubmed” and “Google Scholar” were used as the search engines with terms like “peripheral neuropathy”, “bortezomib induced peripheral neuropathy” and “inflammation”. Original research, case reports and review articles were considered.

Results:
Bortezomib use is associated with the development of peripheral neuropathy. This effect is due to the damage to Schwann cells and dorsal root ganglion neurons; mitochondrial damage; increased ion channel susceptibility; and higher infiltration of macrophages in the spinal cord. All these factors collectively increase the secretion of inflammatory mediators and lead to the development of neuropathic pain.

Conclusion:
Targeting inflammatory mediators may be helpful in the treatment of bortezomib-induced peripheral neuropathy.
Dual Drug Loaded Potassium-contained Graphene Oxide as a Nanocarrier
in Cocktailed Drug Delivery for the Treatment of Human Breast Cancer
Authors: Tiwari Himani , Karki Neha , Tewari Chetna , Pandey Neema , Rana Anita , Rana Sravendra , Pal Mintu , Sahoo Nanda Gopal 
Published: May 2022

Background:
In particular, combinatorial use of anticancer drugs, dual or multiple, onto a specific nanocarrier is one of the most hopeful attempts in the field of drug delivery. The current work reports potassium contained graphene oxide (K-GO) as a nanocarrier in the drug delivery system of two anticancer drugs, gefitinib (GEF) and camptothecin (CPT), simultaneously.

Methods:
To characterize K-GO, K-GO-related single and combined drug systems, different techniques has been performed and studied using spectroscopic tools (Thermo gravimetric Analysis (TGA 4000), UV–visible spectroscopy, Raman spectroscopy, Transmission electron microscopy (TEM)). The in vitro cytotoxicity tests of K-GO, single drug system and the combined drug system were also performed in the human breast cancer MDA-MB-231 cells.

Results:
The release profile of the dual drug conjugates grafted on to the surface of K-GO was found up to 38% in PBS solution over 72hr. The percentage of MDA-MB-231 cell viability were about 18% when treated with K-GO-GEF-CPT combined system, for K-GO, K-GO-GEF, and K-GO-CPT that were only 79 %, 31% and 32 % respectively.

Conclusion:
We studied the loading, release, and delivery of two anticancer drugs onto the fluorescent nanocarrier i.e. K-GO. Due to superb aqueous solubility, excellent biocompatibility and richness of potassium in it make them a promising nanocarrier for single or multiple drug delivery. With this, our novel findings revealed that the loading capacity and cytotoxicity of combined drug loaded system superior then that of individual drug system towards human breast cancer cells.