bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of Religious Philosophy on Tapa Brata (Javanese Asceticism Practice) to Overcome the Social Anxiety During COVID-19 Pandemic Era
Authors: Suryosumunar John Abraham Ziswan 
Published: January 2022

<p><span lang="EN-US">The COVID-19 pandemic, which is global disaster, has an impact on all aspects of human life. Indonesia is one of the countries that has</span><span lang="EN-US"> </span><span lang="EN-US">a high rate of COVID-19</span><span lang="EN-US"> </span><span lang="EN-US">transmission,</span><span lang="EN-US"> </span><span lang="EN-US">this has an effect on various</span><span lang="EN-US"> </span><span lang="EN-US">policies</span><span lang="EN-US"> </span><span lang="EN-US">in suppressing transmission rates by limiting social mobility.</span><span lang="EN-US"> </span><span lang="EN-US">In the midst of this pandemic, people are faced with uncertain conditions that result in levels boredom, fear and even public anxiety increased.</span><span lang="EN-US"> </span><span lang="EN-US">The author is interested in exploring the realities of the COVID-19 pandemic by seeing that there is a relationship between public anxiety during the COVID-19 pandemic and awareness of the need for spirituality in facing the various changes that have occurred.</span><span lang="EN-US"> </span><span lang="EN-US">Using the philosophical hermeneutic method, this qualitative research was conducted by trying to discuss one of the spiritual practices of Javanese society, namely Tapa Brata, and to relate it to public anxiety that occurred during the COVID-19 pandemic.</span><span lang="EN-US"> </span><span lang="EN-US">The results of the discussion</span><span lang="EN-US"> </span><span lang="EN-US">carried out are: (1)</span><span lang="EN-US"> </span><span lang="EN-US">anxiety in the people during the pandemic period is caused by awareness of an uncertain and constantly changing reality.</span><span lang="EN-US"> </span><span lang="EN-US">(2)</span><span lang="EN-US"> </span><span lang="EN-US">Tapa brata is the mental practice of forming a self that is calm and wise in accepting all changes.</span><span lang="EN-US"> </span><span lang="EN-US">(3)</span><span lang="EN-US"> </span><span lang="EN-US">Tapa brata is an inner practice that is personal and</span><span lang="EN-US"> </span><span lang="EN-US">can overcome public anxiety during a pandemic and has a physiological effect in increasing immunity during the Covid-19 pandemic.</span></p>
Impact on Quality of Life of Laparoscopic Nerve-sparing Radical Treatment of Parametrial Deep Infiltrating Endometriosis (Postoperative Pain Assessment and Functional Outcomes)
Authors: Alboni Carlo , Sampogna Veronica , Airoud Mirvana , Malmusi Stefania , Farulla Antonino , Colucci Giuseppe , Mattos Ludovica Camacho , Pecchi Annarita , Marca Antonio La 
Published: January 2022

Abstract
Objective: Complete eradication of parametrial nodules of Deep Infiltrating Endometriosis (DIE) is associated with a high risk of iatrogenic nerves damage and pelvic organs dysfunction. The aim of this study is to evaluate via validated questionnaires the effect of laparoscopic excision of parametrial DIE on quality of life as first outcome and on pain symptoms and post- operative voiding function (bladder and rectal) as secondary outcome.Study design: All patients undergoing laparoscopic excision of posterior or lateral parametrial DIE by a single expert surgeon between January 2013 and March 2017 were included in the study. A nerve-sparing approach was adopted in all patients. Quality of life (QoL) and Functional outcomes were evaluated using validated questionnaires (EHP-30 for the health profile, NBD score for intestinal function, ICIQ-FLUTS for urinary function), administered preoperatively and after surgery. Pain scores were collected before and after surgery using Visual Analogue Scale (VAS).Results: During the study period a total of fifty-nine patients met the inclusion criteria. Fifty-one patients agreed to fill out questionnaires for post-operative outcomes. EHP-30 scores had a significant improvement in all the domains analyzed even in the relationship with children and fertility module despite to the small number of patients answering those questions. No differences were found in terms of urinary function between pre and post-operative questionnaires (ICIQ-FLUTS). Bowel function improved in patients’ subjective perception. The NBD score showed that intestinal dysfunction related only to constipation and was reported as very minor by 76.4% of patients, minor by 11.8%, moderate by 5.9% by and severe by 5.95% of patients. Pain symptoms (VAS score) decreased significantly after surgery with the exception of chronic pelvic pain. (p value < 0,05). Conclusions: Laparoscopic nerve-sparing radical excision of parametrial DIE is safe and effective when performed by an expert surgical equipe. This approach can favorably impact on patients QoL. Moreover, it has proved to result in pain score and voiding function improvements.
Cement Dust Effect from Bokajan Cement Factory on Residents of Vicinity Area: A Study in Assam, India
Authors: Chetia Darshana , Bhuyan Bijoylaxmi 
Published: January 2022

Abstract
Cement manufacturing industries are one of the most common reasons of air pollution, surface and ground water pollution and noise pollution and is also indirectly affecting the people residing near the cement plants. This study was carried out to quantify the cement dust emission from Bokajan Cement Corporation of India’s cement factory falling on the residences and to determine its effect on some selected household activities and general well-being of the people residing near it. An experimental method was carried out to estimate the accumulated cement dust in households. The findings showed that household activities performed by the residence were dependent upon the dust exposure, which means more the dusts are more are the cleaning and maintenance. It was also found that cement dust highly affected general wellbeing of the respondents living in southern direction and lowest affect was observed among the respondents of the east direction.
Identification of Key Genes Related to Immune Infiltration of Cirrhosis via Bioinformatics Analysis
Authors: Du Tong-Yue , Zheng Yi-Shan 
Published: January 2022

Abstract
BackgroundAccumulating researches have indicated that cirrhosis is a vital risk factor for morbidity and mortality worldwide. Nevertheless, the underlying immune-related molecular mechanism remains indistinct.MethodsGene expression profiles of GSE89377 and GSE139602 were investigated to identify differentially expressed genes (DEGs) related to cirrhosis. Enrichment analysis for DEGs was explored. CIBERSORT algorithm was used for evaluating DEGs immune infiltration. The String and Cytoscape database were utilized for analyses hub DEGs with a high tight connection, and the association between hub DEGs and immune cells infiltration was analyzed by Spearman method. Finally, the underlying molecular mechanism of the key DEGs was predicted via KEGG pathway analysis.ResultsIn all, 299 DEGs were attained among them 136 and 163 were up and down-regulated respectively. Then Enrichment function of DEGs and CIBERSORT algorithm showed that they are significant in immune and inflammatory responses. Four hub DEGs (ACTB, TAGLN, VIM, SOX9) were identified. Subsequently, the immune infiltration findings indicated that, the hub DEGs highly related immune cells. Finally, KEGGs pathways were predicted related with ACTB. ConclusionsThis study revealed key DEGs may implement inflammatory immune responses with cirrhosis, which could be used as biomarkers or therapeutic targets.
Object Based Modelling for the Irrigation Suitability using Hydrogeochemical Parameters and Land use Dynamics in the Lower Ganga
Authors: Hasan Mohd Sayeed Ul , Rai Abhishek Kumar 
Published: January 2022

Abstract
The north Indian Ganga basin is one of the densely populated basins of the world. Most agricultural and industrial contaminants drained throughout the river length are likely to be accumulated in the lower part of the Ganga basin. We used ten derived irrigation suitability parameters, which are obtained from 495 sampling points locations, besides using long term climate data (GLDAS_NOAH025_M) using “Technique for Order of Preference by Similarity to Ideal Solution” (TOPSIS) model to get the irrigation suitability map. Multi-Criteria Decision Making (MCDM) using TOPSIS helps make the best choices from the available finite number of alternatives based on their ranking. The obtained entropy weight for irrigation suitability parameters such as Electrical Conductivity (Ec), Sodium Adsorption Ratio (SAR), Magnesium Hardness (MH), Sodium Percent (Na%), Total Hardness (TH), Kelly’s ratio (KR), Permeability Index (PI), Chloride concentration (Cl−), Groundwater Level Fluctuation (GWLF), and lang factor (Df) are found to be 0.08, 0.14, 0.02, 0.02, 0.04, 0.08, 0.01, 0.32, 0.29 and 0.01 respectively. We find that SAR, Cl−, and GWLF controls the water quality for irrigation in the Lower Ganga basin since these parameters have relatively higher entropy weights (more than 0.10). The results obtained from the computed performance index or the closeness coefficient show that the area percent having very good, good, and very poor groundwater quality in the Lower Ganga basin is 34.67%,42.36%, and 22.97%, respectively. The LULC change pattern indicates that the percentage change of water and agricultural land was -11.96 and -0.86%, whereas an increase in the settlement area of 131.42% for the period between 2000 and 2015.
Proteasome Inhibitor Immunotherapy for the Epithelial to Mesenchymal Transition: Assessing the A549 Lung Cancer Cell Microenvironment and the Role of M1, M2a and M2c ‘Hydrocortisone-Polarised’ Macrophages
Authors: Öztürk Selin Engür , DİKMEN Miriş 
Published: January 2022

Abstract
Lung cancer is a leading cause of cancer-related deaths, primarily as a result of metastases. In this metastasis, the epithelial-to-mesenchymal transition (EMT) is essential. Interaction with the cancer cell microenvironment is primarily dependent on M1- and M2-polarized macrophage. In this study, we revealed the EMT-associated activity of M1, M2a and M2c macrophages in A549 lung cancer cells. We established a co-culture model of A549 lung cancer cells utilizing THP-1-derived M1/M2 polarised macrophages to explore the involvement of macrophages in the immune response, apoptosis, and EMT in lung cancer. Although multiple polarising agents are routinely used for M1 and M2 conversion, we assessed a new possible polarising agent, hydrocortisone. M1 increased A549 cell sensitivity to proteasome inhibitors and decreased A549 cell viability by inducing apoptosis. EMT was induced in the presence of M2c macrophages in A549 cells by the levels of vimentin, fibronectin, E-cadherin, NF-kB, CCL-17. We also revealed the antiproliferative effects of bortezomib and ixazomib on A549 cells in both 2D and 3D cultures. Our findings could help develop an immunotherapeutic strategy by shedding light on a previously undiscovered part of the EMT pathway. Furthermore, additional investigation may reveal that polarising tumour-associated macrophages to M1 and eliminating the M2a or particularly the M2c subtype are effective anti-cancer strategies.
Online Symptoms Self-Assessment During Covid-19 Pandemic: an Analysis of a Covid-19 Portal Responses from Canada.
Authors: Egbujie Bonaventure , Francisco Krizia , Alarakhia Mohamed , Hirdes John 
Published: January 2022

Abstract
Background: Covid-19 case was first identified in Canada on January 25, 2020, on a Toronto resident who had travelled to Wuhan China, and not long after, the WHO declared the viral infection a pandemic. Ontario health West created an online self-assessment portal that allowed individuals in the health region and adjourning areas to report any covid related symptoms.Method: Record level data obtained the Ontario Health West self-assessment portal were analyzed. Descriptive statistics using charts and graphs were used to characterize the distribution of responses to the portal. In-depth analysis using correlation, lead-lag analysis, and trend comparison with actual Public Health Canada covid-19 cases for the region were also conducted.Results: A total of 34,144 distinct responses were recorded on the portal between April 10 and July 29, 2020, with 1,250 (3.7%) responding positively to one of the emergency symptoms questions. Trend analysis showed a peak portal response in May 2020 with a smaller rise subsequently in July 2020, coinciding with actual covid-19 peak in the region. The five most reported symptoms on the portal were sore throat (17.2%), headache (12.9%), fatigue (12.3%), digestive problems (12.2%) and cough (9.1%). For four sub-regions, trend of self-report on the portal positively lagged actual public health covid-19 cases, while for one sub-region, the trend positively led the actual public health covid-19 cases for the area.Conclusion: We found correlation between online covid-19 self- assessment data and the confirmed covid-19 cases in the Southwestern region of Ontario. Trends in the covid-19 associated emergency symptoms reported on the portal also tracked confirmed covid-19 cases in the community. Peak response to the portal coincided with the peak volume of confirmed cases in Ontario during the first wave of covid-19 pandemic in Canada, suggesting some consistency between the experiences of portal users and patterns of COVID-19 illness in the community. The portal was a useful tool at the person-level because it provided guidance to individuals about how to access appropriate health services according to the symptoms that they reported and connected them with primary care, reducing unnecessary visit to health facilities for covid-19 related care.
Assessment of Activity of Chalcone Compounds as Inhibitors of 3-Chymotrypsin Like Protease (3CLPro) of SARS-CoV-2: in Silico Study
Authors: Mathpal Shalini , Joshi Tushar , Sharma Priyanka , Pande Veena , Chandra Subhash 
Published: January 2022

Abstract
The COVID-19 is still pandemic due to emerging of the various variant of concern of SARS-CoV2. Hence it is devastating the world, causing significant economic as well as social chaos. This needs great effort to search and develop effective alternatives along with vaccination. Therefore to continue drug discovery endeavors, we used chalcone derivatives to find an effective drug candidate against SARS-CoV2. Chalcone is a common simple scaffold that exists in many diets as well as in traditional medicine. Natural as well as synthetic chalcones have shown numerous interesting biological activities and are also effective in fighting various diseases. Hence various computational methods were applied to find out potential inhibitors of 3CLPro using a library of 3000 compounds of chalcones. Firstly the screening by structure-based pharmacophore model yielded 84 hits that were subjected to molecular docking. The top 10 docked compounds were characterized for stability by using 100 nanoseconds (ns) molecular dynamic (MD) simulation approach. Further, the binding free energy calculation by MMPBSA showed that four compounds bind to 3CLPro enzyme with high affinity i.e., -87.962(KJ/mol), -66.125 (KJ/mol), -59.589(KJ/mol), and -66.728(KJ/mol) respectively. Since chalcone is a common simple scaffold that is present in many diets as well as in traditional medicine, we suggest that screened compounds may emerge as promising drug candidates for SARS-CoV-2. These compounds may be investigated in vitro to evaluate the efficacy againstSARS-CoV-2.
SorCS2 Dynamically Interacts with TrkB and GluN2B to Control Neurotransmission and Huntington’s Disease Progression
Authors: Salašová Alena , Degn Niels Sanderhoff , Paveliev Mikhail , Madsen Niels Kjærgaard , Benito Saray López , Casarotto Plinio , Ovesen Peter Lund , Vestergaard Benedicte , Udrea Andreea Cornelia , Kisiswa Lilian , Woloszczuková Lucie , Faress Islam , Nabavi Sadegh , Castrén Eero , Arévalo Juan Carlos , Holm Mai Marie , Kjølby Mads Fuglsang , Bølcho Ulrik , Nykjaer Anders 
Published: January 2022

Abstract
Background: Huntington’s disease (HD) is a fatal neurodegenerative disorder characterized by progressive motor dysfunction and loss of medium spiny neurons (MSNs) in dorsal striatum. Brain-derived neurotrophic factor (BDNF) sustains functionality and integrity of MSNs, and thus reduced BDNF signaling is integral to the disease. Mutations in BDNF receptor SorCS2 were recently identified in HD patients. Our study investigates the role of SorCS2 in MSNs biology and in HD progression. Methods: We derived a double transgenic line by crossbreeding SorCS2 deficient (KO) mice with the HD mouse model R6/1. Subsequently, we characterized the SorCS2 KO; R6/1 line by a set of behavioral and biochemical studies to evaluate phenotypes related to HD. Moreover, in combination with electrophysiology and super resolution microscopy techniques, we addressed the molecular mechanism by which SorCS2 controls synaptic activity in MSNs neurons. Results: We show that SorCS2 is expressed in MSNs with reduced levels in R6/1 HD model, and that SorCS2 deficiency exacerbates the disease progression in R6/1 mice. Furthermore, we find that SorCS2 binds TrkB and the NMDA receptor subunit GluN2B, which is required to control neurotransmission in corticostriatal synapses. While BDNF stimulates SorCS2-TrkB complex formation to enable TrkB signaling, it disengages SorCS2 from GluN2B, leading to enrichment of the subunit at postsynaptic densities. Consequently, long-term potentiation (LTP) is abolished in SorCS2 deficient mice, despite increased striatal TrkB and unaltered BDNF expression. However, the addition of exogenous BDNF rescues the phenotype. Finally, GluN2B, but not GluN2A, currents are also severely impaired in the SorCS2 KO mice. Conclusions: We formulate a novel molecular mechanism by which SorCS2 acts as a molecular switch. SorCS2 targets TrkB and GluN2B into postsynaptic densities to enable BDNF signaling and NMDAR dependent neurotransmission in the dorsal striatum. Remarkably, the binding between SorCS2 and TrkB or GluN2B, respectively, is mutually exclusive and controlled by BDNF. This mechanism provides an explanation why deficient SorCS2 signaling severely aggravates HD progression in mice. Moreover, we provide evidence that this finding might represent a general mechanism of SorCS2 signaling found in other brain areas, thus increasing its relevance for other neurological and psychiatric impairments.
Command-Filtered Adaptive Neural Network Backstepping Quantized Control for Fractional-order Nonlinear Systems with Asymmetric Actuator Dead-zone via Disturbance Observer
Authors: Yu Jinzhu , Li Shenggang , Liu Heng 
Published: January 2022

Abstract
An adaptive neural network (NN) backstepping quantized control based on command filter and disturbance observer is proposed for fractional-order nonlinear systems with asymmetric actuator dead-zone and unknown external disturbance in this paper. An adaptive NN mechanism is designed to estimate unknown functions, and a command filter is introduced to estimate the virtual control variable as well as its derivative, so the ``explosion of complexity" issue can be avoided existed in the classical backstepping method. To handle the unknown external disturbance, a fractional-order disturbance observer is developed. Moreover, a hysteresis-type quantizer is used to quantify the final input signal to overcome the system performance damage caused by the actuator dead-zone. The quantized input signal can ensure that all the involved signals keep bounded and the tracking error converges to an arbitrarily small region of the origin. Finally, two examples are presented to verify the effectiveness of the proposed method.
Attributes Inequality in Multidimensional Poverty MeasuresFuzzy Modeling
Authors: Belhadj Besma 
Published: January 2022

Abstract
Poverty is recently considered to be a multidimensional one. That is to say the poor can suffer multiple disadvantages at the same time. This paper aims to further develop and refine the multidimensional poverty measure using Fuzzy Sets Theory (FST). The application of FST starts with the choice of membership functions and the rules to manipulate to integrate attributes inequality in multidimensional poverty measure. An application based on individual well-being data from Tunisian households in 2015 is presented to illustrate use proposed concepts. JEL classification: P46; I32; D81; C00;
Hounsfield Units Value is a Better Predictor of Bone Mineral Density Than the Vertebral Bone Quality Score of Magnetic Resonance Imaging in Patients with Lumbar Degenerative Diseases
Authors: Li Wenshuai , Zhu Houze , Tong Tong , Hua Zijian , Zhao Xuan , Shen Yong , Wang Linfeng 
Published: January 2022

Abstract
Background: Computed tomography Hounsfield unit (HU) and magnetic resonance imaging (MRI)-based vertebral bone quality (VBQ) score are both alternative tool to the dual energy x-ray absorptiometry(DEXA) scan T-score to quantify the bone quality. However, it is not known which method more accurately reflects vertebral bone mineral density. Purpose: To evaluate the best method for evaluating vertebral bone mineral density in patients undergoing lumbar spine surgery.Methods: Eighty-five patients who had at most two vertebrae with severe degeneration at L1–L4 were retrospectively reviewed.HU value was measured by axial CT image, VBQ score was calculated by T1-weighted lumbar MRI image, and L1-L4 T-score and bone mineral density (BMD) were measured by DEXA.The correlation of the vertebral HU value and VBQ score to the T-score was analyzed.Results: There were 52 female and 33 male patients. The average age was 57.18±9.65 years . HU values had a positive correlation with BMD and T-score. The correlation coefficients between HU and T-score was 0.751(<0.001) for L1; 0.699(<0.001) for L2; 0.618(<0.001) for L3; 0.543(<0.001) for L4; and 0.677(<0.001) for L1-4.However,VBQ score had a negative correlation with BMD and T-score. The correlation coefficients between VBQ score and T-score was -0.231(<0.05) for L1; -0.246(<0.05) for L2; -0.268(<0.05) for L3; -0.252(<0.05) for L4; and -0.346(<0.01) for L1-4. The correlation coefficients of HU value at L1–L4 were higher than the correlation coefficients of VBQ score . Conclusions: HU value was a better predictor of vertebral bone mineral density than VBQ score in patients with lumbar degenerative disease.