bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution of micro-pores in Ni–Cr alloys via molten salt dealloying
Authors: Yu Lin-Chieh , Clark Charles , Liu Xiaoyang , Ronne Arthur , Layne Bobby , Halstenberg Phillip , Camino Fernando , Nykypanchuk Dmytro , Zhong Hui , Ge Mingyuan , Lee Wah-Keat , Ghose Sanjit , Dai Sheng , Xiao Xianghui , Wishart James F. , Chen-Wiegart Yu-chen Karen 
Published: December 2022

AbstractPorous materials with high specific surface area, high porosity, and high electrical conductivity are promising materials for functional applications, including catalysis, sensing, and energy storage. Molten salt dealloying was recently demonstrated in microwires as an alternative method to fabricate porous structures. The method takes advantage of the selective dissolution process introduced by impurities often observed in molten salt corrosion. This work further investigates molten salt dealloying in bulk Ni–20Cr alloy in both KCl–MgCl2 and KCl–NaCl salts at 700 ℃, using scanning electron microscopy, energy dispersive spectroscopy, and X-ray diffraction (XRD), as well as synchrotron X-ray nano-tomography. Micro-sized pores with irregular shapes and sizes ranging from sub-micron to several microns and ligaments formed during the process, while the molten salt dealloying was found to progress several microns into the bulk materials within 1–16 h, a relatively short reaction time, enhancing the practicality of using the method for synthesis. The ligament size increased from ~ 0.7 μm to ~ 1.3 μm in KCl–MgCl2 from 1 to 16 h due to coarsening, while remaining ~ 0.4 μm in KCl–NaCl during 16 h of exposure. The XRD analysis shows that the corrosion occurred primarily near the surface of the bulk sample, and Cr2O3 was identified as a corrosion product when the reaction was conducted in an air environment (controlled amount sealed in capillaries); thus surface oxides are likely to slow the morphological coarsening rate by hindering the surface diffusion in the dealloyed structure. 3D-connected pores and grain boundary corrosion were visualized by synchrotron X-ray nano-tomography. This study provides insights into the morphological and chemical evolution of molten salt dealloying in bulk materials, with a connection to molten salt corrosion concerns in the design of next-generation nuclear and solar energy power plants.
The influence of temperature on cellulose swelling at constant water density
Authors: Torstensen Jonathan , Ottesen Vegar , Rodríguez-Fabià Sandra , Syverud Kristin , Johansson Lars , Lervik Anders 
Published: December 2022

AbstractWe have in this paper investigated how water sorbs to cellulose. We found that both cellulose nanofibril (CNF) and cellulose nanocrystal (CNC) films swell similarly, as they are both mainly composed of cellulose. CNF/CNC films subjected to water at 0.018 kg/m3at 25 °C and 39 °C, showed a decrease in swelling from ~ 8 to 2%. This deswelling increased the tensile index of CNF-films by ~ 13%. By molecular modeling of fibril swelling, we found that water sorbed to cellulose exhibits a decreased diffusion constant compared to bulk water. We quantified this change and showed that diffusion of sorbed water displays less dependency on swelling temperature compared to bulk water diffusion. To our knowledge, this has not previously been demonstrated by molecular modeling. The difference between bulk water diffusion (DWW) and diffusion of water sorbed to cellulose (DCC) increased from DWW − DCC ~ 3 × 10–5 cm/s2at 25 °C to DWW − DCC ~ 8.3 × 10–5 cm/s2at 100 °C. Moreover, water molecules spent less successive time sorbed to a fibril at higher temperatures.
Conditioned medium of mesenchymal stem cells pretreated with H2O2 promotes intestinal mucosal repair in acute experimental colitis
Authors: Liu Peng , Xie Xiao-ran , Wu Hao , Li Huan , Chi Jing-shu , Liu Xiao-ming , Luo Ju , Tang Yu , Xu Can-xia 
Published: December 2022

AbstractMesenchymal stem cells (MSCs) are a new therapeutic strategy for inflammatory bowel disease (IBD), and their efficacy has been widely recognized. However, there are still some challenges in cell therapy, including stable cell passage, laboratory conditions for cell culture, high-cost burden, and poor transplantation. The conditioned medium (CM) of MSCs is considered be an excellent alternative to cell transplantation, but the paracrine group in MSC-CM is limited in variety and low in concentration, which cannot meet the therapeutic needs of injured tissues and needs to be optimized. Pretreatment with low concentration of hydrogen peroxide (H2O2) can not only protect cells from oxidative damage, but also play a role similar to growth factors and regulate the physiological function of stem cells, to obtain an improved conditioned medium. To determine the optimal protocol for pretreatment of MSCs with H2O2, and to study the efficacy and potential mechanism of MSC-CM pretreated with H2O2 on Dextran Sulfate Sodium (DSS)-induced acute experimental colitis. MSCs were exposed to different concentrations of H2O2, and the optimal H2O2 pretreatment conditions were determined by evaluating their critical cell functional properties. H2O2-pretreated MSC-CM was transplanted into experimental mouse colitis by enema at 2, 4, and 6 days in modeling, and the changes of colonic tissue structure, the levels of inflammation and oxidative stress, the molecular changes of Nrf2/Keap1/ARE axis, and the related indicators of apoptosis in colonic epithelial cells were observed in each group. In vitro, Pretreated MSCs with 25 μM H2O2 significantly enhanced cell proliferation, migration, and survival, but had no effect on apoptosis. In vivo, MSC-CM treatment decreased apoptosis and extracellular matrix deposition, and maintained the mechanical barrier and permeability of colonic epithelial cells in experimental mouse colitis. Mechanistically, H2O2-pretreated MSC-CM against reactive oxygen species (ROS) production and MDA generation, accompanied by increases in components of the enzymatic antioxidant system includes SOD, CAT, GSH-PX, and T-AOC, which is through the up-regulation of the Nrf2, HO-1, and NQO-1 antioxidant genes. Our data confirmed that 25 μM H2O2 pretreated MSC-CM treatment could effectively improve intestinal mucosal repair in experimental colitis, which may be achieved by activating Nrf2/Keap1/ARE pathway.
Concomitant immunity to M. tuberculosis infection
Authors: Joslyn Louis R. , Flynn JoAnne L. , Kirschner Denise E. , Linderman Jennifer J. 
Published: December 2022

AbstractSome persistent infections provide a level of immunity that protects against reinfection with the same pathogen, a process referred to as concomitant immunity. To explore the phenomenon of concomitant immunity during Mycobacterium tuberculosis infection, we utilized HostSim, a previously published virtual host model of the immune response following Mtb infection. By simulating reinfection scenarios and comparing with data from non-human primate studies, we propose a hypothesis that the durability of a concomitant immune response against Mtb is intrinsically tied to levels of tissue resident memory T cells (Trms) during primary infection, with a secondary but important role for circulating Mtb-specific T cells. Further, we compare HostSim reinfection experiments to observational TB studies from the pre-antibiotic era to predict that the upper bound of the lifespan of resident memory T cells in human lung tissue is likely 2–3 years. To the authors’ knowledge, this is the first estimate of resident memory T-cell lifespan in humans. Our findings are a first step towards demonstrating the important role of Trms in preventing disease and suggest that the induction of lung Trms is likely critical for vaccine success.
σ2R/TMEM97 in retinal ganglion cell degeneration
Authors: Wang Hua , Peng Zhiyou , Li Yiwen , Sahn James J. , Hodges Timothy R. , Chou Tsung-Han , Liu Qiong , Zhou Xuezhi , Jiao Shuliang , Porciatti Vittorio , Liebl Daniel J. , Martin Stephen F. , Wen Rong 
Published: December 2022

AbstractThe sigma 2 receptor (σ2R) was recently identified as an endoplasmic reticulum (ER) membrane protein known as transmembrane protein 97 (TMEM97). Studies have shown that σ2R/TMEM97 binding compounds are neuroprotective, suggesting a role of σ2R/TMEM97 in neurodegenerative processes. To understand the function of σ2R/TMEM97 in neurodegeneration pathways, we characterized ischemia-induced retinal ganglion cell (RGC) degeneration in TMEM97−/− mice and found that RGCs in TMEM97−/− mice are resistant to degeneration. In addition, intravitreal injection of a selective σ2R/TMEM97 ligand DKR-1677 significantly protects RGCs from ischemia-induced degeneration in wildtype mice. Our results provide conclusive evidence that σ2R/TMEM97 plays a role to facilitate RGC death following ischemic injury and that inhibiting the function of σ2R/TMEM97 is neuroprotective. This work is a breakthrough toward elucidating the biology and function of σ2R/TMEM97 in RGCs and likely in other σ2R/TMEM97 expressing neurons. Moreover, these findings support future studies to develop new neuroprotective approaches for RGC degenerative diseases by inhibiting σ2R/TMEM97.
Body composition variations between injured and non-injured professional soccer players
Authors: Martins Francisco , França Cíntia , Henriques Ricardo , Ihle Andreas , Przednowek Krzysztof , Marques Adilson , Lopes Hélder , Sarmento Hugo , Gouveia Élvio Rúbio 
Published: December 2022

AbstractProfessional soccer is characterized by its physical demands, making players’ exposure to high injury risks a growing problem. It is crucial to study the factors associated with injuries in professional soccer. This study aimed to investigate the relationship between age, body composition, and others variables related with the injury profile of professional soccer players of a specific Portuguese team. Also, it analyzed the impact of the injury profile on soccer’s variations in body fat (BF%), skeletal muscle mass (SMM) and total body water (TBW) throughout the season. The sample comprised 31 male professional soccer players competing in the First Portuguese Soccer League. Older players had a higher prevalence of muscular injuries. Midfielders and forwards showed the highest number of muscular injuries during the season being quadriceps the most affected zone. Considering players’ BF% [Wilks’ Lambda = 0.42, F (7, 23) = 4.61, p = 0.002, r = 0.58], SMM [Wilks’ Lambda = 0.59, F (6, 23) = 2.70, p = 0.039, r = 0.41] and TBW [Wilks’ Lambda = 0.54, F (7, 23) = 2.80, p = 0.029, r = 0.46] there was a substantial main effect for the assessments performed throughout the season and the injury status. Age assumes relevance in explaining the injury profile. The impact of the injury profile on soccer's variations in BF%, SMM and TBW throughout the season must be analyzed considering the clinical relevance.
Non-inversion conservation tillage as an underestimated driver of tillage erosion
Authors: Öttl L. K. , Wilken F. , Hupfer A. , Sommer M. , Fiener P. 
Published: December 2022

AbstractTillage erosion is a widely underestimated process initiating soil degradation especially in case of large agricultural fields located in rolling topography. It is often assumed that, conservation, non-inversion tillage causes less tillage erosion than conventional inversion tillage. In this study, tillage erosion was determined on three paired plots comparing non-inversion chisel versus inversion mouldboard tillage. The experiments were performed at three sites in Northeast Germany with gentle, moderate, and steep slope, while tillage depth (0.25 m) and speed (≈ 6 km h−1) were kept constant during all experiments. The results indicate that non-inversion tillage produces significantly more soil movement compared to inversion tillage. The soil translocation distance was by a factor of 1.3–2.1 larger in case of chisel tillage. The largest difference in translocation distance and tillage transport coefficient (ktil) was found on the gentle slope exhibiting the lowest soil cohesion. Our results together with an evaluation of ktil values derived from literature and standardised for 0.25 m tillage depth contradict the general assumption that non-inversion tillage reduces tillage erosion. In tillage erosion dominated areas, non-inversion tillage applied with high tillage speed and depth potentially increases tillage erosion and fails its purpose to serve as soil conservation measure.
Computer-aided diagnosis through medical image retrieval in radiology
Authors: Silva Wilson , Gonçalves Tiago , Härmä Kirsi , Schröder Erich , Obmann Verena Carola , Barroso María Cecilia , Poellinger Alexander , Reyes Mauricio , Cardoso Jaime S. 
Published: December 2022

AbstractCurrently, radiologists face an excessive workload, which leads to high levels of fatigue, and consequently, to undesired diagnosis mistakes. Decision support systems can be used to prioritize and help radiologists making quicker decisions. In this sense, medical content-based image retrieval systems can be of extreme utility by providing well-curated similar examples. Nonetheless, most medical content-based image retrieval systems work by finding the most similar image, which is not equivalent to finding the most similar image in terms of disease and its severity. Here, we propose an interpretability-driven and an attention-driven medical image retrieval system. We conducted experiments in a large and publicly available dataset of chest radiographs with structured labels derived from free-text radiology reports (MIMIC-CXR-JPG). We evaluated the methods on two common conditions: pleural effusion and (potential) pneumonia. As ground-truth to perform the evaluation, query/test and catalogue images were classified and ordered by an experienced board-certified radiologist. For a profound and complete evaluation, additional radiologists also provided their rankings, which allowed us to infer inter-rater variability, and yield qualitative performance levels. Based on our ground-truth ranking, we also quantitatively evaluated the proposed approaches by computing the normalized Discounted Cumulative Gain (nDCG). We found that the Interpretability-guided approach outperforms the other state-of-the-art approaches and shows the best agreement with the most experienced radiologist. Furthermore, its performance lies within the observed inter-rater variability.
Non‑small cell lung cancer carrying PBRM1 mutation suggests an immunologically cold phenotype leading to immunotherapy failure even with high TMB
Authors: Miao Xia-ye , Wu Hao , Ye Bi-cheng , Yi Qian-wen , Lin Fang-nan , Wang Yi-lin , Ren Chuan-li , Jiang Yan-fang , Li Ang 
Published: December 2022

AbstractHigh tumor mutation load (TMB-H, or TMB ≥ 10) has been approved by the U.S. FDA as a biomarker for pembrolizumab treatment of solid tumors, including non‑small cell lung cancer (NSCLC). Patients with cancer who have immunotherapy-resistant gene mutations cannot achieve clinical benefits even in TMB-H. In this study, we aimed to identify gene mutations associated with immunotherapy resistance and further informed mechanisms in NSCLC. A combined cohort of 350 immune checkpoint blockade-treated patients from Memorial Sloan Kettering Cancer Center (MSKCC) was used to identify genes whose mutations could negatively influence immunotherapy efficacy. An external NSCLC cohort for which profession-free survival (PFS) data were available was used for independent validation. CIBERSORT algorithms were used to characterize tumor immune infiltrating patterns. Immunogenomic features were analysed in the TCGA NSCLC cohort. We observed that PBRM1 mutations independently and negatively influence immunotherapy efficacy. Survival analysis showed that the overall survival (OS) and PFS of patients with PBRM1 mutations (MT) were significantly shorter than the wild type (WT). Moreover, compared with PBRM1-WT/TMB-H group, OS was worse in the PBRM1-MT/TMB-H group. Notably, in patients with TMB-H/PBRM1-MT, it was equal to that in the low-TMB group. The CIBERSORT algorithm further confirmed that the immune infiltration abundance of CD8+ T cells and activated CD4+ memory T was significantly lower in the MT group. Immunogenomic differences were observed in terms of immune signatures, T-cell receptor repertoire, and immune-related genes between WT and MT groups. Nevertheless, we noticed an inverse relationship, given that MT tumors had a higher TMB than the WT group in MSKCC and TCGA cohort. In conclusion, our study revealed that NSCLC with PBRM1 mutation might be an immunologically cold phenotype and exhibited immunotherapy resistance. NSCLC with PBRM1 mutation might be misclassified as immunoresponsive based on TMB.
Relationship among surface electric double layer of cardiomyocyte membrane and toxicology of digoxin and opening of ion channels
Authors: Zhou Ying , Hao Yanfei , Sun Pei , Chen Ming , Zhang Ting , Wu Hong 
Published: December 2022

AbstractWe applied a new idea that the potential effect can change the ion adsorption structure on the cell surface to explore the mechanism of digoxin poisoning and the regulation of ion channels. The effects of digoxin on the electrophoretic mobility and behaviors (non-contraction or contraction or autorhythmicity) of cardiomyocytes were observed by single-cell electrophoresis technique (imitate the opening method of in vivo channel) and the method of decomposing surface potential components on the cells. As well as affect the association with electrical activity. The results suggested that the increase of cardiomyocytes transmembrane potential and the Na+–K+ exchange on the cell surface of the action potential phase 4 caused by the poisoning dose of digoxin, leading to the oscillation of adsorbed ions on the cell surface and the incomplete channel structure, which were the mechanism of cardiac ectopic beats. The results revealed that the opening of ion channels is regulated by the surface electric double layer of the cell membrane.
Study on fracture development and progressive failure characteristics of downstream dam-type expansion tailings reservoir
Authors: Zhang Hongyue , Jin Jiaxu , Xu Yihong 
Published: December 2022

AbstractWith the economic development and industrialization, the increasingly accumulated tailings ponds in China have become a great risk. Due to the difficulty of selecting proper site for a new reservoir in Yunnan, a sub-dam was built at the downstream original reservoir. This study explored the fracture development and progressive failure characteristics of the tailings reservoir area after capacity expansion based on a similarity experiment and the numerical simulation. The results showed that the primary cracks in the reservoir area were more than those at the top of the sub-dam. With the increase of the upper load, the primary cracks further developed and penetrated the whole sub-dam top, and the sub-cracks were then produced under the concentrate stress of the primary cracks. After the further development of the sub-cracks, the secondary cracks parallel to the primary cracks were formed on the outer slope of the sub-dam. The progressive failure of a tailings dam can be summarized as: the maximum shear stress was firstly generated at the toe of the slope or the top of the dam which then extended to the top of the sub-dam in the form of a curve and finally formed the failure surface by connecting with the primary fracture of the tensile plastic zone at the top of the dam. The study also found that in the process of tailings accumulation in the new reservoir area, tailings would form "back pressure slope protection" at the initial dam of the original reservoir, which not only effectively delayed the occurrence of shear failure, but also inhibited the generation and penetration of tensile plastic zone.
Auditory Pitch Perception in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis
Authors: Chen Yu , Tang Enze , Ding Hongwei , Zhang Yang 
Published: December 2022

Purpose:
Pitch plays an important role in auditory perception of music and language. This study provides a systematic review with meta-analysis to investigate whether individuals with autism spectrum disorder (ASD) have enhanced pitch processing ability and to identify the potential factors associated with processing differences between ASD and neurotypicals.

Method:
We conducted a systematic search through six major electronic databases focusing on the studies that used nonspeech stimuli to provide a qualitative and quantitative assessment across existing studies on pitch perception in autism. We identified potential participant- and methodology-related moderators and conducted metaregression analyses using mixed-effects models.

Results:

On the basis of 22 studies with a total of 464 participants with ASD, we obtained a small-to-medium positive effect size (
g
= 0.26) in support of enhanced pitch perception in ASD. Moreover, the mean age and nonverbal IQ of participants were found to significantly moderate the between-studies heterogeneity.

Conclusions:
Our study provides the first meta-analysis on auditory pitch perception in ASD and demonstrates the existence of different developmental trajectories between autistic individuals and neurotypicals. In addition to age, nonverbal ability is found to be a significant contributor to the lower level/local processing bias in ASD. We highlight the need for further investigation of pitch perception in ASD under challenging listening conditions. Future neurophysiological and brain imaging studies with a longitudinal design are also needed to better understand the underlying neural mechanisms of atypical pitch processing in ASD and to help guide auditory-based interventions for improving language and social functioning.

Supplemental Material:

https://doi.org/10.23641/asha.21614271
The Low Emission Oil and Gas Open reference platform—An off‐grid energy system for renewable integration studies
Authors: Svendsen Harald G. , Vrana Til Kristian , Holdyk Andrzej , Schümann Heiner 
Published: December 2022

AbstractThis article introduces and describes the integrated energy system of the Low Emission Oil and Gas Open reference platform. It is a hypothetical case meant to represent a typical oil and gas installation in the North Sea. The aim of this detailed specification is to serve as an open reference case where all the information about it can be publicly shared, facilitating benchmarking and collaboration. The relevance of this reference case of an off‐grid energy system is not limited to the oil and gas industry, since it can also be seen as a special kind of electrical micro grid. The remote offshore location makes it especially relevant for studying offshore wind power and ocean energy sources like wave power. The specification has an emphasis on the energy system and electrical configuration, but also includes a basic description of the oil field and processing system. The intention is that it will serve as a basis for energy system studies and relating power system stability analyses regarding the integration of renewable energy sources. This allows for comparisons of a base case with different design modifications, new operational planning methods, power management strategies and control concepts. Examples of possible modifications are the replacement of gas turbines by wind turbines, addition of energy storage systems, a more variable operation of loads etc. The last part of the article demonstrates the behaviour of the reference platform implemented in two software tools: one for operational planning and one for dynamic power system analyses.