bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of the immune system in posttraumatic stress disorder
Authors: Katrinli Seyma , Oliveira Nayara C. S. , Felger Jennifer C. , Michopoulos Vasiliki , Smith Alicia K. 
Published: August 2022

AbstractPosttraumatic stress disorder (PTSD) develops in a subset of individuals upon exposure to traumatic stress. In addition to well-defined psychological and behavioral symptoms, some individuals with PTSD also exhibit elevated concentrations of inflammatory markers, including C-reactive protein, interleukin-6, and tumor necrosis factor-α. Moreover, PTSD is often co-morbid with immune-related conditions, such as cardiometabolic and autoimmune disorders. Numerous factors, including lifetime trauma burden, biological sex, genetic background, metabolic conditions, and gut microbiota, may contribute to inflammation in PTSD. Importantly, inflammation can influence neural circuits and neurotransmitter signaling in regions of the brain relevant to fear, anxiety, and emotion regulation. Given the link between PTSD and the immune system, current studies are underway to evaluate the efficacy of anti-inflammatory treatments in those with PTSD. Understanding the complex interactions between PTSD and the immune system is essential for future discovery of diagnostic and therapeutic tools.
Directing HIV-1 for degradation by non-target cells, using bi-specific single-chain llama antibodies
Authors: Stam Jord C. , de Maat Steven , de Jong Dorien , Arens Mathia , van Lint Fenna , Gharu Lavina , van Roosmalen Mark H. , Roovers Rob C. , Strokappe Nika M. , Wagner Ralf , Kliche Alexander , de Haard Hans J. , van Bergen en Henegouwen Paul M. , Nijhuis Monique , Verrips C. Theo 
Published: August 2022

AbstractWhile vaccination against HIV-1 has been so far unsuccessful, recently broadly neutralizing antibodies (bNAbs) against HIV-1 envelope glycoprotein were shown to induce long-term suppression in the absence of antiretroviral therapy in patients with antibody-sensitive viral reservoirs. The requirement of neutralizing antibodies indicates that the antibody mediated removal (clearance) of HIV-1 in itself is not efficient enough in these immune compromised patients. Here we present a novel, alternative approach that is independent of a functional immune system to clear HIV-1, by capturing the virus and redirecting it to non-target cells where it is internalized and degraded. We use bispecific antibodies with domains derived from small single chain Llama antibodies (VHHs). These bind with one domain to HIV-1 envelope proteins and with the other domain direct the virus to cells expressing epidermal growth factor receptor (EGFR), a receptor that is ubiquitously expressed in the body. We show that HIV envelope proteins, virus-like particles and HIV-1 viruses (representing HIV-1 subtypes A, B and C) are efficiently recruited to EGFR, internalized and degraded in the lysosomal pathway at low nM concentrations of bispecific VHHs. This directed degradation in non-target cells may provide a clearance platform for the removal of viruses and other unwanted agents from the circulation, including toxins, and may thus provide a novel method for curing.
Single-phase transformerless nine-level inverter with voltage boosting ability for PV fed AC microgrid applications
Authors: Almakhles Dhafer J. , Sathik M. Jagabar 
Published: August 2022

AbstractThis letter presents a new single-stage common ground type nine-level (9L) switched-capacitor inverter topology with single-phase operation. The primary objective of this topology is to reduce the leakage current, voltage boosting, and maintain the voltage across the switched capacitors. The output voltage (vo) can be boosted up to two times the input voltage (vin). The various modes of operations are explained in detail, and the simulation results are provided to illustrate the effectiveness of the proposed topology. Next, the experimental results are obtained from a 500 W prototype setup and tested under different scenarios such as load variations, input voltage, and modulation index. Both simulation and experimental results have a good agreement regarding efficiency and performance. Finally, a detailed comparative study is performed with other recent 9L switched-capacitor inverters to prove the merits of the proposed topology.
Neutrophil extracellular traps are involved in enhanced contact hypersensitivity response in IL-36 receptor antagonist-deficient mice
Authors: Hasegawa Yurie , Iwata Yohei , Fukushima Hidehiko , Tanaka Yoshihito , Watanabe Soichiro , Saito Kenta , Ito Hiroyuki , Sugiura Mizuki , Akiyama Masashi , Sugiura Kazumitsu 
Published: August 2022

AbstractLoss-of-function homozygous or compound heterozygous mutations in IL36RN, which encodes interleukin-36 receptor antagonist (IL-36Ra), have been implicated in the pathogenesis of skin disorders. We previously reported that Il36rn−/− mice exhibit an enhanced contact hypersensitivity (CHS) response through increased neutrophil recruitment. In addition, Il36rn−/− mice show severe imiquimod-induced psoriatic skin lesions and enhanced neutrophil extracellular trap (NET) formation. We hypothesized that NETs may play an important role in the CHS response. To confirm this, we examined the CHS response and NET formation in Il36rn−/− mice. Il36rn−/− mice showed enhanced CHS responses, increased infiltration of inflammatory cells, including neutrophils, CD4+ T cells, and CD8+ T cells, NET formation, and enhanced mRNA expression of cytokines and chemokines, including IL-1β, C-X-C motif chemokine ligand (CXCL)1, CXCL2, and IL-36γ. Furthermore, NET formation blockade improved the CHS response, which consequently decreased inflammatory cell infiltration and NET formation. Consistently, we observed decreased expression of these cytokines and chemokines. These findings indicate that IL-36Ra deficiency aggravates the CHS response caused by excessive inflammatory cell recruitment, NET formation, and cytokine and chemokine production, and that NET formation blockade alleviates the CHS response. Thus, NET formation may play a prominent role in the CHS response.
Parameter estimation on multivalent ITC data sets
Authors: Erlekam Franziska , Zumbansen Maximilian , Weber Marcus 
Published: August 2022

AbstractThe Wiseman fitting can be used to extract binding parameters from ITC data sets, such as heat of binding, number of binding sites, and the overall dissociation rate. The classical Wiseman fitting assumes a direct binding process and neglects the possibility of intermediate binding steps. In principle, it only provides thermodynamic information and not the kinetics of the process. In this article we show that a concentration dependent dissociation constant could possibly stem from intermediate binding steps. The mathematical form of this dependency can be exploited with the aid of the Robust Perron Cluster Cluster Analysis method. Our proposed extension of the Wiseman fitting rationalizes the concentration dependency, and can probably also be used to determine the kinetic parameters of intermediate binding steps of a multivalent binding process. The novelty of this paper is to assume that the binding rate varies per titration step due to the change of the ligand concentration and to use this information in the Wiseman fitting. We do not claim to produce the most accurate values of the binding parameters, we rather present a novel method of how to approach multivalent bindings from a different angle.
Galerkin finite element analysis for the augmentation in thermal transport of ternary-hybrid nanoparticles by engaging non-Fourier’s law
Authors: Sohail Muhammad , Nazir Umar , El-Zahar Essam R. , Park Choonkil , Jamshed Wasim , Mukdasai Kanit , Galal Ahmed M. 
Published: August 2022

AbstractBoosting of thermal transportation is the demand of current era. Several techniques have been used to do so. One of an important way is the mixing of nanoparticles to boost thermal performance. Current investigation has been prepared to study the inclusion of tri hybrid nanoparticles in Prandtl fluid model past over a stretched heated sheet. Modelling of consider problem has been done due to consideration of movement in flow in Cartesian coordinates which results coupled partial differential equation system thermal transport in presented by considering generalized heat flux model and heat generation/absorption. The derived coupled complex partial differential equations (PDEs) system is simplified by engaging boundary layer theory. Such developed model is used in coolants regarding automobiles, dynamics in fuel and production of solar energy, fuel cells, optical chemical sensors, automotive parts, dental products, cancer therapy, electrical insulators and dental products. Handling of complex PDEs for the solution is a challenging task. Due to complexity in computational work these PDEs have been transformed into ordinary differential equations (ODEs) after applying similarity transformation afterwards converted ODEs have been approximated via finite element algorithm coded in MAPLE 18.0 symbolic computational package. Comparative study has been presented for the validity of code and authenticity of obtained result. It is observed that fluid velocity for tri-hybrid nanoparticles is higher than fluidic motion for pure fluid, nanofluid and hybrid nanomaterial.
Association between central obesity and incident diabetes mellitus among Japanese: a retrospective cohort study using propensity score matching
Authors: Cao Changchun , Hu Haofei , Zheng Xiaodan , Zhang Xiaohua , Wang Yulong , He Yongcheng 
Published: August 2022

AbstractPrevious evidence revealed that central obesity played a vital role in the development of diabetes mellitus (DM). However, because of imbalanced confounding variables, some studies have not wholly established the association between central obesity and diabetes. Propensity score matching (PSM) analysis can minimize the impact of potential confounding variables. Therefore, the aim of the present study was to explore the relationship between central obesity and diabetes in the Japanese population by using PSM analysis. This retrospective cohort study included 15,453 Japanese adults who were free of diabetes at baseline between 2004 and 2015, which provided all medical records for individuals participating in the physical exam. Central obesity at baseline was an independent variable, and incident diabetes during follow-up was an outcome variable. Using a 1:1 PSM analysis, the present retrospective cohort study included 1639 adults with and without central obesity. Additionally, we employed a doubly robust estimation method to identify the association between central obesity and diabetes. Subjects with central obesity were 92% more likely to develop DM (HR = 1.65, 95%CI 1.12, 2.41). After adjusting for covariates, subjects with central obesity had a 72% increased risk of developing DM compared with subjects with non-central obesity in the PSM cohort (HR = 1.72, 95% CI 1.16, 2.56). Central obesity individuals had a 91% higher risk of DM than non-central obesity individuals, after adjustment for propensity score (HR = 1.91, 95% CI 1.29, 2.81). In sensitivity analysis, the central obesity group had a 44% (HR = 1.44, 95% CI 1.09, 1.90) and 59% (HR = 1.59, 95% CI1.35, 1.88) higher risk of DM than the non-central obesity group in the original and weighted cohorts after adjusting for confounding variables, respectively. Central obesity was independently associated with an increased risk of developing diabetes. After adjustment for confounding covariates, central obesity participants had a 72% higher risk of development of diabetes than non-central obesity individuals in the PSM cohort.
Mechanisms of photoinduced toxicity of AgNPs to the microalgae Chlorella pyrenoidosa in the presence of hematite nanoparticles: insights from transcriptomics, metabolomics and the photochemical index
Authors: Cao Manman , Wang Fei , Zhou Beihai , Chen Huilun , Yuan Rongfang , Ma Shuai , Geng Huanhuan , Xing Baoshan 
Published: August 2022

AgNPs attachment to HemNPs have caused photoinduced cytotoxicity, elevating the AgNPs toxicity to C. pyrenoidosa by producing free radicals and improving photocatalytic activity under illumination.
Shaping Hox gene activity to generate morphological diversity across vertebrate phylogeny
Authors: Mallo Moisés 
Published: August 2022

Abstract
The importance of Hox genes for the development and evolution of the vertebrate axial skeleton and paired appendages has been recognized for already several decades. The steady growth of genomic sequence data from an increasing number of vertebrate species, together with the improvement of methods to analyze genomic structure and interactions, as well as to control gene activity in various species has refined our understanding of Hox gene activity in development and evolution. Here, I will review recent data addressing the influence of Hox regulatory processes in the evolution of the fins and the emergence of the tetrapod limb. In addition, I will discuss the involvement of posterior Hox genes in the control of vertebrate axial extension, focusing on an apparently divergent activity that Hox13 paralog group genes have on the regulation of tail bud development in mouse and zebrafish embryos.
Supporting Emergent Bilinguals Who Use Augmentative and Alternative Communication and Their Families: Lessons in Telepractice From the COVID-19 Pandemic
Authors: King Marika , Ward Hannah , Soto Gloria , Barrett Tyson S. 
Published: August 2022

Purpose:
The purpose of this project was to examine the effect of the COVID-19 pandemic on speech-language pathologist (SLP) service provision for emergent bilinguals who use augmentative and alternative communication (AAC). One prominent issue in AAC service delivery is the efficacy and feasibility of providing AAC services via telepractice. The COVID-19 pandemic intensified this issue as most providers, clients, and families adjusted to remote service delivery models. While emerging evidence supports telepractice in AAC, little is known about the potential benefits and challenges of telepractice for emergent bilinguals who use AAC and their families.

Method:

Data were collected via a nationwide survey. Licensed SLPs (
N
= 160) completed an online questionnaire with Likert-type, multiple-choice, and open-ended questions, analyzed using mixed methods.

Results:
Findings illustrated a shift in service delivery from in-person to telepractice and hybrid (both telepractice and in-person) models. Overall, child intervention outcomes declined for emergent bilinguals who used AAC during the COVID-19 pandemic, regardless of service delivery format. However, collaboration increased for many providers and families. Qualitative analyses highlighted barriers to AAC service provision for emergent bilinguals who use AAC that were exacerbated by the COVID-19 pandemic, as well as factors that facilitated collaboration and family engagement.

Conclusion:
These findings suggest that, despite challenges, telepractice or hybrid services may be a promising approach to provide more culturally responsive, family-centered care for emergent bilinguals who use AAC.

Supplemental Material:

https://doi.org/10.23641/asha.20405673
Derivation of chest‐lead ECG from limb‐lead using temporal convolutional network in variational mode decomposition domain
Authors: Chuang Yu‐Hung , Huang Yu‐Chieh , Chang Wen‐Whei , Chien Jen‐Tzung 
Published: August 2022

AbstractStandard 12‐lead electrocardiography (ECG) is the primary tool for detection and diagnosis of cardiovascular diseases (CVDs). Most wearable ECG devices only provide single limb‐lead measurement, limiting their practical use in CVD diagnosis. This study proposes a method of chest‐lead ECG reconstruction from a single limb lead using a temporal convolutional network (TCN). The TCN is learned in the variational mode decomposition domain to reduce the non‐stationary characteristics of ECG data. Experiments on two public databases suggested that automated diagnosis of CVDs in wearable ECG devices is likely to achieve through the proposed approach.
Scattering properties of protoplanetary dust analogs with microwave analogy: Aggregates of fractal dimensions from 1.5 to 2.8
Authors: Tobon Valencia Vanesa , Geffrin Jean-Michel , Ménard François , Milli Julien , Renard Jean-Baptiste , Tortel Hervé , Eyraud Christelle , Litman Amélie , Rannou Pascal , Maalouf Azar , Laur Vincent 
Published: August 2022

Context. The growth of dust grains in protoplanetary disks is not understood in detail. Several studies have proposed the presence of aggregates and irregular grains to overcome the physical barriers in grain growth models. In order to understand the scattering properties of these aggregates, laboratory measurements of light scattering and microwave scattering have been developed over the last 50 years.
Aims. We aim to measure the scattering properties of different protoplanetary analog aggregates with fractal dimensions of 1.5, 1.7, 2.0, 2.5, and 2.8.
Methods. We used the microwave scattering technique (microwave analogy) for the measurements. The analog particles were virtually generated and fabricated by 3D printing with a controlled size (scaling factor), geometry, and refractive index. The seven analogs were measured at wavelengths ranging from 16.7 mm to 100 mm, leading to aggregate size parameters ranging from Xagg = 1 to Xagg = 20. The results were compared to finite element method calculations of the same analogs for cross-validation.
Results. The phase function and the degree of linear polarization were deduced from the scattered field measurements of the different aggregates. These scattering properties are compared and discussed as a function of the fractal dimension.
Conclusions. The scattering properties of aggregates with different fractal dimensions are different. Three different realizations of aggregates with the same fractal dimension but different monomer configurations yield the same phase functions. We verified that the maximum degree of linear polarization is higher for porous aggregates than for compact aggregates. Furthermore, the maximum polarization occurs at larger scattering angles for high fractal dimensions, while the half width at half maximum of the phase functions present larger values for small fractal dimensions.
Nephrologische Versorgung in der freien Dialysepraxis
Authors: Weinreich Thomas 
Published: August 2022

ZUSAMMENFASSUNGDie Versorgung chronisch nierenkranker Patient*innen mit und ohne Dialysetherapie erfolgt zu weiten Teilen ambulant. Die Versorgungslandschaft in Deutschland wird dabei, im Unterschied zu den meisten Ländern weltweit, von frei niedergelassenen Fachärzt*innen geprägt. Die Tätigkeit niedergelassener Ärzt*innen bietet wie in kaum einem anderen Setting die Möglichkeit, das Arbeitsumfeld unternehmerisch frei und eigenverantwortlich zu gestalten. Eine Herausforderung, aber auch eine Chance für eine motivierende, erfüllende berufliche Tätigkeit. Der Verband Deutsche Nierenzentren e. V. (DN e. V.) mit vielfältigen Angeboten rund um Ein- und Ausstieg in eine Praxis, Praxisorganisation und wirtschaftliches Management unterstützt seine Mitglieder und setzt sich berufspolitisch für die Belange der niedergelassenen Nephrolog*innen ein.
Artificial intelligence-based diagnosis of abnormalities in small-bowel capsule endoscopy
Authors: Ding Zhen , Shi Huiying , Zhang Hang , Zhang Hao , Tian Shuxin , Zhang Kun , Cai Sicheng , Ming Fanhua , Xie Xiaoping , Liu Jun , Lin Rong 
Published: August 2022

Background Further development of deep learning-based artificial intelligence (AI) technology to automatically diagnose multiple abnormalities in small-bowel capsule endoscopy (SBCE) videos is necessary. We aimed to develop an AI model, to compare its diagnostic performance with doctors of different experience levels, and to further evaluate its auxiliary role for doctors in diagnosing multiple abnormalities in SBCE videos.
Methods The AI model was trained using 280 426 images from 2565 patients, and the diagnostic performance was validated in 240 videos.
Results The sensitivity of the AI model for red spots, inflammation, blood content, vascular lesions, protruding lesions, parasites, diverticulum, and normal variants was 97.8 %, 96.1 %, 96.1 %, 94.7 %, 95.6 %, 100 %, 100 %, and 96.4 %, respectively. The specificity was 86.0 %, 75.3 %, 87.3 %, 77.8 %, 67.7 %, 97.5 %, 91.2 %, and 81.3 %, respectively. The accuracy was 95.0 %, 88.8 %, 89.2 %, 79.2 %, 80.8 %, 97.5 %, 91.3 %, and 93.3 %, respectively. For junior doctors, the assistance of the AI model increased the overall accuracy from 85.5 % to 97.9 % (P  < 0.001, Bonferroni corrected), comparable to that of experts (96.6 %, P > 0.0125, Bonferroni corrected).
Conclusions This well-trained AI diagnostic model automatically diagnosed multiple small-bowel abnormalities simultaneously based on video-level recognition, with potential as an excellent auxiliary system for less-experienced endoscopists.
Nrf2 Mediated Heme Oxygenase-1 Activation Contributes to Diabetic
Wound Healing – an Overview
Authors: Ramachandran Vadivelan , Mohanasundaram Tharani , Tiwari Ruchi , Tiwari Gaurav , Vijayakumar Putta , Bhongiri Bhargav , Xavier Rinu Mary 
Published: August 2022

AbstractDiabetic wound healing is a complicated procedure because hyperglycemia changes
the various stages of wound healing. In type 2 diabetes mellitus (T2DM),
oxidative stress is proven to be a critical factor in causing non-healing wounds
and aggravating the inflammatory phase, resulting in the amputation of lower
limbs in T2DM patients. This makes scientists figure out how to control
oxidative stress and chronic inflammation at the molecular level. Nuclear factor
erythroid 2- related factor 2 (Nrf2) releases antioxidant proteins to suppress
reactive oxygen species (ROS) activation and inflammation. The current review
discusses the role of Nrf2 in improving diabetic wound healing by reducing the
production of ROS and thus reducing oxidative stress, as well as inhibiting
nuclear factor kappa B (NF-kB) dissociation and nuclear translocation, which
prevents the release of inflammatory mediators and increases antioxidant protein
levels, thereby improving diabetic wound healing. As a result, the researcher
will be able to find a more effective diabetic wound healing therapy.