bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Exercise for the Prevention and Treatment of Cancer-Related Lymphedema: A Systematic Review with Meta-analysis
Authors: HAYES SANDRA CHRISTINE , SINGH BEN , REUL-HIRCHE HILDEGARD , BLOOMQUIST KIRA , JOHANSSON KARIN , JÖNSSON CHARLOTTA , PLINSINGA MELANIE LOUISE 
Published: March 2022

ABSTRACT

Introduction
The purpose of this systematic review and meta-analysis was to evaluate the effects of exercise on (i) the prevention of cancer-related lymphedema (CRL) and (ii) the treatment of CRL, lymphedema-associated symptoms, and other health outcomes among individuals with CRL.

Methods
An electronic search was undertaken for exercise studies measuring lymphedema and involving individuals at risk of developing or with CRL. The Effective Public Health Practice Project Quality scale was used to assess study quality, and overall quality of evidence was assessed using the Grading of Recommendation, Assessment, Development and Evaluation approach. Meta-analyses were performed to evaluate effects of exercise on CRL incidence, existing CRL status, lymphedema-associated symptoms, and health outcomes.

Results
Twelve studies (n = 1955; 75% moderate-high quality) and 36 studies (n = 1741; 58% moderate-high quality) were included in the prevention and treatment aim, respectively. Relative risk of developing CRL for those in the exercise group compared with the nonexercise group was 0.90 (95% confidence interval (CI), 0.72 to 1.13) overall and 0.49 (95% CI, 0.28 to 0.85) for those with five or more lymph nodes removed. For those with CRL in the exercise group, the standardized mean difference (SMD) before to after exercise of CRL was −0.11 (95% CI, −0.22 to 0.01), and compared with usual care postintervention, the SMD was −0.10 (95% CI, −0.24 to 0.04). Improvements after intervention were observed for pain, upper-body function and strength, lower-body strength, fatigue, and quality of life for those in the exercise group (SMD, 0.3–0.8; P < 0.05).

Conclusions
Findings support the application of exercise guidelines for the wider cancer population to those with or at risk of CRL. This includes promotion of aerobic and resistance exercise, and not just resistance exercise alone, as well as unsupervised exercise guided by symptom response.
Eccentric Exercise Causes Specific Adjustment in Pyruvate Oxidation by Mitochondria
Authors: HODY STÉPHANIE , WARREN BLAIR E. , VOTION DOMINIQUE-MARIE , ROGISTER BERNARD , LEMIEUX HÉLÈNE 
Published: March 2022

ABSTRACT

Introduction
The impact of eccentric exercise on mitochondrial function has only been poorly investigated and remains unclear. This study aimed to identify the changes in skeletal muscle mitochondrial respiration, specifically triggered by a single bout of eccentric treadmill exercise.

Methods
Male adult mice were randomly divided into eccentric (ECC; downhill running), concentric (CON; uphill running), and unexercised control groups (n = 5/group). Running groups performed 18 bouts of 5 min at 20 cm·s−1 on an inclined treadmill (±15° to 20°). Mice were sacrificed 48 h after exercise for blood and quadriceps muscles collection. Deep proximal (red) and superficial distal (white) muscle portions were used for high-resolution respirometric measurements.

Results
Plasma creatine kinase activity was significantly higher in the ECC compared with CON group, reflecting exercise-induced muscle damage (P < 0.01). The ECC exercise induced a significant decrease in oxidative phosphorylation capacity in both quadriceps femoris parts (P = 0.032 in proximal portion, P = 0.010 in distal portion) in comparison with the CON group. This observation was only made for the nicotinamide adenine dinucleotide (NADH) pathway using pyruvate + malate as substrates. When expressed as a flux control ratio, indicating a change related to mitochondrial quality rather than quantity, this change seemed more prominent in distal compared with proximal portion of quadriceps muscle. No significant difference between groups was found for the NADH pathway with glutamate or glutamate + malate as substrates, for the succinate pathway or for fatty acid oxidation.

Conclusions
Our data suggest that ECC exercise specifically affects pyruvate mitochondrial transport and/or oxidation 48 h after exercise, and this alteration mainly concerns the distal white muscle portion. This study provides new perspectives to improve our understanding of the mitochondrial adaptation associated with ECC exercise.
Hydrogen production via aqueous-phase reforming for high-temperature proton exchange membrane fuel cells - a review
Authors: Lakhtaria Paranjeet , Ribeirinha Paulo , Huhtinen Werneri , Viik Saara , Sousa José , Mendes Adélio 
Published: March 2022

Aqueous-phase reforming (APR) can convert methanol and other oxygenated hydrocarbons to hydrogen and carbon dioxide at lower temperatures when compared with the corresponding gas phase process. APR favours the water-gas shift (WGS) reaction and inhibits alkane formation; moreover, it is a simpler and more energy efficient process compared to gas-phase steam reforming. For example, Pt-based catalysts supported on alumina are typically selected for methanol APR, due to their high activity at temperatures of circa 200°C. However, non-noble catalysts such as nickel (Ni) supported on metal-oxides or zeolites are being investigated with promising results in terms of catalytic activity and stability. The development of APR kinetic models and reactor designs is also being addressed to make APR a more attractive process for producing in situ hydrogen. This can also lead to the possibility of APR integration with high-temperature proton exchange membrane fuel cells. The integration can result into increased overall system efficiency and avoiding critical issues faced in the state-of-the-art fuel cells integrated with methanol steam reforming.
Educational analytics in distance learning: application features and development prospects
Authors: Car'kova Evgeniya 
Published: March 2022

The article discusses aspects of the application of educational analytics, which is currently an actual scientific and technical direction, to improve the effectiveness of the educational process in the professional training of university students. Due to the widespread use of modern information technologies, which continue to develop and become an important part of a person's daily life, it is natural to pay increasing attention to determining the areas of application of these technologies, including for improving the activities of educational organizations. The use of educational analytics in universities serves as an important prerequisite for building high-quality systems for analyzing "digital traces" of students in electronic educational environments (EE), allowing them to make reliable forecasts, solve problems of classification and clustering of EE users, establish non-obvious dependencies between events and phenomena, and offer recommendations for improving the methods and approaches used in the learning process.
Considerable attention is paid to the consideration of the specifics of the use of various types of data sources that can be used when analyzing the behavior of students in the learning process.
Along with the enumeration of the undeniable advantages of using educational analytics, the problem of staffing in educational organizations is identified, which prevents its widespread use. The author suggests ways to solve this problem, including through the development and implementation of special programs of additional professional education in the field of data analysis.
Based on the review of scientific literature and his own pedagogical experience, the author notes the barriers hindering the widespread introduction of educational analytics tools into the activities of educational organizations, and formulates recommendations on the selection and use of tools when conducting data mining in electronic educational environments.
Dynamic Relaxations for Online Bipartite Matching
Authors: Torrico Alfredo , Toriello Alejandro 
Published: March 2022

Online bipartite matching (OBM) is a fundamental model underpinning many important applications, including search engine advertisement, website banner and pop-up ads, and ride hailing. We study the independent and identically distributed (i.i.d.) OBM problem, in which one side of the bipartition is fixed and known in advance, whereas nodes from the other side appear sequentially as i.i.d. realizations of an underlying distribution and must immediately be matched or discarded. We introduce dynamic relaxations of the set of achievable matching probabilities; show how they theoretically dominate lower dimensional, static relaxations from previous work; and perform a polyhedral study to theoretically examine the new relaxations’ strength. We also discuss how to derive heuristic policies from the relaxations’ dual prices in a similar fashion to dynamic resource prices used in network revenue management. We finally present a computational study to demonstrate the empirical quality of the new relaxations and policies. Summary of Contribution: Online bipartite matching (OBM) is one of the fundamental problems in the area of online decision analysis with a wide variety of applications in operations research and computer science, for example, online advertising, ride sharing, and general resource allocation. Over the last decades, both communities have been interested in the design and analysis of new approaches. Our main contribution is to provide a polyhedral study that considers the problem’s sequential nature. Specifically, we achieve this via dynamic relaxations. We also discuss how to derive heuristic policies from the relaxations’ dual prices. We support our theoretical findings with a detailed computational study.
Lender Trust and Bank Loan Contracts
Authors: Hagendorff Jens , Lim Sonya , Nguyen Duc Duy 
Published: March 2022

We examine the contractual implications of a lender’s trust for corporate loans. We measure how trusting a lender is using the average trust attitude in the chief executive officer’s ancestral country of origin. We find that banks with trusting CEOs charge lower interest rates in U.S. syndicated loans. This effect is identified within existing lender–borrower relationships and similar types of loans. Further analyses indicate that trust reduces the cost of credit by boosting the perceived credibility of borrower information and by mitigating contracting problems. We corroborate our findings by conducting a survey of loan officers with experience in loan syndication. This paper was accepted by Gustavo Manso, finance. Supplemental Material: The internet appendix and data are available at https://doi.org/10.1287/mnsc.2022.4371 .
Explaining the Failure of the Unconditional CAPM with the Conditional CAPM
Authors: Hasler Michael , Martineau Charles 
Published: March 2022

When the cost of hedging is nil, the conditional capital asset pricing model (CAPM) holds. We empirically test the conditional CAPM by regressing asset returns onto the product of their conditional betas and market returns. Estimated intercepts are not statistically different from zero, implying that the conditional CAPM successfully explains the conditional level of asset returns. Yet, unconditional betas do not explain the cross section of average asset returns; the unconditional CAPM fails. We show why and how the success of the conditional CAPM actually explains the failure of the unconditional CAPM, thereby rationalizing the coexistence of these two intriguing results. This paper was accepted by Gustavo Manso, finance. Funding: The University of Texas at Dallas and the University of Toronto provided financial support. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2022.4381 .
Is Adopting Mass Customization a Path to Environmentally Sustainable Fashion?
Authors: Alptekinoğlu Aydın , Örsdemir Adem 
Published: March 2022

Problem definition: In high-product-variety businesses like fashion, mass production (MP) systems create environmental waste in the form of overproduction on a colossal scale. Mass customization (MC) has been proposed—without solid evidence—as a solution. In this paper, we analyze whether MC can indeed offer a win-win solution that helps both the bottom line and the environment. We also study the impact of three real policy options: promoting MC, charging a disposal fee for overproduction, and recycling. Academic/practical relevance: There is increasing interest in mass-customizing fashion goods, not only because consumers value customization, but also because MC is perceived to be environmentally friendly. Our paper puts this advocacy for MC to the test. We contribute to the literature, which has been largely silent on the issue, by uncovering when MC offers a win-win and relating such market outcomes to policy ideas. Methodology: We develop an analytical model of an MP firm adopting MC (going hybrid). The firm’s profit-maximizing variety, price, and inventory decisions then form the basis of our understanding the environmental impact of adopting MC and assessing various policy options. Results: Adopting MC can be a win-win, but it can also increase overproduction and hurt the environment. Our policy analyses reveal two kinds of insights. The first kind is about whether a policy expands win-win outcomes—encouraging sustainable adoption of MC. Among the policy ideas we explore, only promoting MC so as to increase consumers’ tolerance for waiting for mass-customized products can do that unambiguously. The second kind of insight is about whether a policy reduces the hybrid firm’s environmental impact. Only a disposal fee and costly recycling programs can do that unambiguously. Managerial implications: For MC adoption to be a win-win, policy makers must (1) work on convincing consumers to wait for bespoke fashion; (2) target MP firms with low cost of variety (high product-mix flexibility) with disposal fees or costly recycling programs; and (3) encourage those with relatively higher cost of variety to develop/acquire technology that would make recycling profitable. History: This paper has been accepted for the Manufacturing & Service Operations Management Special Section on Responsible Research in Operations Management. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2022.1088 .
3D time-lapse imaging of a mouse embryo using intensity diffraction
tomography embedded inside a deep learning framework
Authors: Pierré William , Hervé Lionel , Paviolo Chiara , Mandula Ondrej , Remondiere Vincent , Morales Sophie , Grudinin Sergei , Ray Pierre F. , Dhellemmes Magali , Arnoult Christophe , Allier Cédric 
Published: March 2022

We present a compact 3D diffractive microscope that can be inserted directly in a cell incubator for long-term observation of developing organisms. Our setup is particularly simple and robust, since it does not include any moving parts and is compatible with commercial cell culture containers. It has been designed to image large specimens (

>

100
×
100
×
100

µ

m

3

) with subcellular resolution. The sample’s optical properties [refractive index (RI) and absorption] are reconstructed in 3D from intensity-only images recorded with different illumination angles produced by an LED array. The reconstruction is performed using the beam propagation method embedded inside a deep-learning network where the layers encode the optical properties of the object. This deep neural network is trained for a given multiangle intensity acquisition. After training, the weights of the neural network deliver the 3D distribution of the optical properties of the sample. The effect of spherical aberrations due to the sample holder/air interfaces are taken into account in the forward model. Using this approach, we performed time-lapse 3D imaging of preimplantation mouse embryos over six days. Images of embryos from a single cell (low-scattering regime) to the blastocyst stage (highly scattering regime) were successfully reconstructed. Due to its subcellular resolution, our system can provide quantitative information on the embryos’ development and viability. Hence, this technology opens what we believe to be novel opportunities for 3D label-free live-cell imaging of whole embryos or organoids over long observation times.
Cantilevered adaptive fiber-optics collimator based on piezoelectric bimorph actuators
Authors: Ma Yanxing , Luo Gen , He Shuyue , Chen Zilun , Su Rongtao , Ma Pengfei , Zhou Pu , Si Lei 
Published: March 2022

A novel, to the best of our knowledge, cantilever construction design of an adaptive fiber-optics collimator (AFOC) based on piezoelectric bimorph actuators for tip/tilt control is introduced. With this new cantilever structure, an AFOC with a diameter of only 6 mm was developed, and the output laser beam deviation angle and resonance frequency of the device were measured. The experimental results show that this new AFOC can provide more than 1 mrad deflection angle at a 20 V driving voltage, and the first resonance frequency is about 500 Hz. Further, in order to verify whether the cantilever structure can be used in a high-power fiber collimator, a high-power

X

−

Y

positioner with an 8 mm diameter fiber end cap was developed. The experimental results show that the high-power

X

−

Y

positioner can output more than 2 kW laser power and provide about 330 µm displacement of the fiber end cap in the

X

direction and about 770 µm in the

Y

direction at a 150 V driving voltage.
Development of a dual antigen lateral flow immunoassay for detecting Yersinia pestis
Authors: Hau Derrick , Wade Brian , Lovejoy Chris , Pandit Sujata G. , Reed Dana E. , DeMers Haley L. , Green Heather R. , Hannah Emily E. , McLarty Megan E. , Creek Cameron J. , Chokapirat Chonnikarn , Arias-Umana Jose , Cecchini Garett F. , Nualnoi Teerapat , Gates-Hollingsworth Marcellene A. , Thorkildson Peter N. , Pflughoeft Kathryn J. , AuCoin David P. 
Published: March 2022

Background
Yersinia pestis is the causative agent of plague, a zoonosis associated with small mammals. Plague is a severe disease, especially in the pneumonic and septicemic forms, where fatality rates approach 100% if left untreated. The bacterium is primarily transmitted via flea bite or through direct contact with an infected host. The 2017 plague outbreak in Madagascar resulted in more than 2,400 cases and was highlighted by an increased number of pneumonic infections. Standard diagnostics for plague include laboratory-based assays such as bacterial culture and serology, which are inadequate for administering immediate patient care for pneumonic and septicemic plague.

Principal findings
The goal of this study was to develop a sensitive rapid plague prototype that can detect all virulent strains of Y. pestis. Monoclonal antibodies (mAbs) were produced against two Y. pestis antigens, low-calcium response V (LcrV) and capsular fraction-1 (F1), and prototype lateral flow immunoassays (LFI) and enzyme-linked immunosorbent assays (ELISA) were constructed. The LFIs developed for the detection of LcrV and F1 had limits of detection (LOD) of roughly 1–2 ng/mL in surrogate clinical samples (antigens spiked into normal human sera). The optimized antigen-capture ELISAs produced LODs of 74 pg/mL for LcrV and 61 pg/mL for F1 when these antigens were spiked into buffer. A dual antigen LFI prototype comprised of two test lines was evaluated for the detection of both antigens in Y. pestis lysates. The dual format was also evaluated for specificity using a small panel of clinical near-neighbors and other Tier 1 bacterial Select Agents.

Conclusions
LcrV is expressed by all virulent Y. pestis strains, but homologs produced by other Yersinia species can confound assay specificity. F1 is specific to Y. pestis but is not expressed by all virulent strains. Utilizing highly reactive mAbs, a dual-antigen detection (multiplexed) LFI was developed to capitalize on the diagnostic strengths of each target.
Care-seeking and health insurance among pregnancy-related deaths: A population-based study in Jember District, East Java Province, Indonesia
Authors: Anggondowati Trisari , Deviany Poppy E. , Latief Kamaluddin , Adi Annis C. , Nandiaty Fitri , Achadi Anhari , Kalter Henry D. , Weaver Emily H. , Rianty Tika , Ruby Mahlil , Wahyuni Sri , Riyanti Akhir , Lisnawati Naintina , Kusariana Nissa , Achadi Endang L. , Setel Philip W. 
Published: March 2022

Background
Despite the increased access to facility-based delivery in Indonesia, the country’s maternal mortality remains unacceptably high. Reducing maternal mortality requires a good understanding of the care-seeking pathways for maternal complications, especially with the government moving toward universal health coverage. This study examined care-seeking practices and health insurance in instances of pregnancy-related deaths in Jember District, East Java, Indonesia.

Methods
This was a community-based cross-sectional study to identify all pregnancy-related deaths in the district from January 2017 to December 2018. Follow-up verbal and social autopsy interviews were conducted to collect information on care-seeking behavior, health insurance, causes of death, and other factors.

Findings
Among 103 pregnancy-related deaths, 40% occurred after 24 hours postpartum, 36% during delivery or within the first 24 hours postpartum, and 24% occurred while pregnant. The leading causes of deaths were hemorrhage (38.8%), pregnancy-induced hypertension (20.4%), and sepsis (16.5%). Most deaths occurred in health facilities (81.6%), primarily hospitals (74.8%). Nearly all the deceased sought care from a formal health provider during their fatal illness (93.2%). Seeking any care from an informal provider during the fatal illness was more likely among women who died after 24 hours postpartum (41.0%, OR 7.4, 95% CI 1.9, 28.5, p = 0.049) or during pregnancy (29.2%, OR 4.4, 95% CI 1.0, 19.2, p = 0.003) than among those who died during delivery or within 24 hours postpartum (8.6%). There was no difference in care-seeking patterns between insured and uninsured groups.

Conclusions
The fact that women sought care and reached health facilities regardless of their insurance status provides opportunities to prevent deaths by ensuring that every woman receives timely and quality care. Accordingly, the increasing demand should be met with balanced readiness of both primary care and hospitals to provide quality care, supported by an effective referral system.