bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer-related Cognitive Impairment in Patients With Newly Diagnosed Aggressive Lymphoma Undergoing Standard Chemotherapy: a Longitudinal Feasibility Study
Authors: Gates Priscilla , Krishnasamy Meinir , Wilson Carlene , Hawkes Eliza A , Dore Vincent , Perchyonok Yuliya , Rowe Christopher C , Walker Adam K , Vardy Janette L , de Ruiter Michiel , Cushion Tania , Dhillon Haryana M , Gough Karla 
Published: January 2022

Abstract
PurposeCancer-related cognitive impairment (CRCI) is a recognised adverse consequence of cancer and its treatment. This study assessed the feasibility of collecting longitudinal data on cognition in patients with newly diagnosed, aggressive lymphoma undergoing standard therapy with curative intent via self-report, neuropsychological assessment, peripheral markers of inflammation and neuroimaging. An exploration and description of patterns of cancer-related cognitive impairment over the course of treatment and recovery was also explored. MethodsEligible participants completed repeated measures of cognition including self-report, neuropsychological assessment, blood cell–based inflammatory markers, and neuroimaging at three pre-specified time-points, Time 1 (T1) – pre-treatment (treatment naïve), Time 2 (T2) – mid-treatment, and Time 3 (T3) – six to eight weeks post-completion of treatment. ResultsOf 33 eligible participants, 30 (91%, 95% CI: 76%, 97%) were recruited over 10 months. The recruitment rate was 3 patients/month (95% CI: 2.0, 4.3 patients/month). Reasons for declining included feeling overwhelmed and rapid treatment commencement. Mean age was 57 years (SD=17 years) and 16/30 (53%) were male. Most patients (20/30, 67%) had diffuse large B cell lymphoma or Hodgkin lymphoma (4/30, 13%). The neuroimaging sub-study was optional, 11/30 participants (37%) were eligible to take part, and all agreed. Retention and compliance with all assessments was very high at all time-points. Only one patient was withdrawn from the study due to disease progression.ConclusionsFindings from this study demonstrate that it is feasible to longitudinally assess cognitive status and impairment in people with newly diagnosed aggressive lymphoma during their initial treatment and recovery and larger studies should be undertaken within other cancer groups.
Struggling With Extensive Informed Consent Procedures for Cancer Trails – Is There Even a Benefit for the Patients?
Authors: Tilch Marie-Kristin , Moringlane Alice , Schranz Melanie , Theobald Matthias , Hess Georg 
Published: January 2022

Abstract
PurposeInformed consent procedures in clinical trials often differ in length and complexity to those in clinical routine care. Little is known about the benefit of extensive procedures as intended in clinical trials compared to procedures in routine cancer treatment. MethodsIn two different clinical studies performed at a comprehensive cancer center, we compared patients’ comprehension and satisfaction of current informed consent procedures in routine clinical care with the level of comprehension and satisfaction of patients treated within clinical trials. Patients with a new cancer diagnosis and recent informed consent received a questionnaire about satisfaction, comprehension, time management and physician-patient relationship of the informed consent process. Patients in cohort 1 consented to cancer treatment within a clinical trial and were additionally interviewed in a structured way; patients in cohort 2 consented to “standard” chemotherapy and received a follow-up questionnaire after 6 months. ResultsIn cohort 1, 82 patients completed the questionnaire and had an additional structured interview. They were treated in 41 different trials, receiving up to 40 pages of educational material. In cohort 2, 89 patients completed the first and 52 completed the follow-up questionnaire after receiving a standard informed consent form of 6 pages. Subjective understanding and satisfaction with the information provided was equally very high. However, deficits in objective understanding were observed in both cohorts. ConclusionExtensive informed consent procedures for clinical cancer trials have not been associated with a higher level of satisfaction or measurable objective understanding, therefore the benefit seems to be limited.
Implementing The Multi Expression Programming, Nonlinear Regression, Artificial Neural Network, and M5P-Tree Models to Predict The Long-Term of Compressive Strength of Cement- Mortar Modified With Fly Ash
Authors: Abdalla Aso , Mohammed Ahmed 
Published: January 2022

Abstract
In the recent decade, supplementary cementing ingredients have become an essential part of various strength ranges of concrete and cement-mortar mix design. Examples are natural materials, by-products, industrial wastes, and materials that require less energy and time to generate. Fly ash is one of the most widely utilized additional cementing ingredients. Fly ash is a by-product substance produced by coal combustion. It's being used in cement mortar and concrete as a pozzolanic substance. It has demonstrated significant influence in improving liquid and solid properties of cement mortar, such as compressive strength. Multi Expression Programming (MEP) is employed in this study to estimate the compressive strength (CS) of cement mortar modified with fly ash. The outcomes of this model were compared and evaluated with several other models such as the Nonlinear Regression model (NLR), Artificial Neural Network (ANN), and M5P-tree models that have been used in the construction fields. The input parameters included water/cement ratio (w/c), curing time (t days), and fly ash content (FA %), while the target property was compressive strength up to 360 days of curing. Four hundred fifty (450) data are collected from previous literature on modifying cement mortar with fly ash for that purpose. The water/cement ratio ranged from 0.24 to 1.2, and the fly ash was used to replace cement up to 55% (%wt. of dry cement). Based on the Coefficient of Determination (R2), Root Mean Squared Error (RMSE), Scatter Index (SI), Objective (OBJ), Mean Absolute Error (MAE), t-test value, the uncertainty of 95%, Performance Index (ρ), and boxplot for actual and predicted compressive strength. The MEP model performed better than other developed models according to evaluation tools. The compressive strength was also correlated with flexural and splitting tensile strengths using different nonlinear models.
Inflammatory Cytokines Response to Isometric Handgrip Exercise and the Effects of Duration and Intensity of the Isometric Effort in Prehypertensive Subjects
Authors: OGBUTOR GODSDAY UDOJI , Nwangwa Eze Kingsley , Ogbeivor Collins , Ezeonu Nkemakonam , Chukwuemeka Ephraim , Ugoeze Chinedu Francis , Ezunu Emmanuel , Nwabueze Zuwaira Odegua , John Igweh Chukwuka 
Published: January 2022

Abstract
BACKGROUND

Chronic low grade systemic inflammation has been identified as a major risk factor for chronic diseases. The potential for physical exercise to induce anti-inflammatory effect is now increasingly being explored but there is paucity of data regarding the effects isometric exercise on inflammatory cytokines. The objective of this study was to investigate the responses of selected inflammatory cytokines to isometric handgrip exercise and identify possible effects of intensity and duration of the isometric effort on these variables. CASE PRESENTATION: A total of one hundred and ninety two (N=192) sedentary pre-hypertensive subjects, aged between 30-50years were recruited into the study and randomly distributed into three groups of 64 subjects each. The subjects performed a 24 consecutive day’s isometric hand grip exercise at 30% Maximum Voluntary Contraction. At the end of the 24 days, the group one (GP1) discontinued with the exercise protocol while the group two (GP2) continued the exercise protocol for another 24 consecutive days and the group three (GP3) continued with the exercise protocol for another 24 consecutive days but at 50%MVC. The parameters used to assess for the inflammatory cytokine variables included interleukin 10, interleukin 6 and tumor necrotic factor. At the end of the study, there was an increase in the resting values of interleukin 10 across the three groups while the resting values of interleukin 6 and tumor necrotic factor reduced significantly across groups. CONCLUSIONS: The reductions noted in the pro-inflammatory cytokines and increase in the anti-inflammatory cytokines could have a positive impact in the management of chronic diseases. It was also found that increase in intensity and/or duration produced more proportionate effect.
Bibliometric Analysis of Research Trends Related to Carbon Sources for Nitrogen Removal in Wastewater Treatment
Authors: Li Yuan , Ni Jin , Liu Feng , Zhu Wenbin , Wu Chuanfu , Wang Qunhui , Gao Ming 
Published: January 2022

Abstract
The low organic carbon content of municipal wastewater weakens the effectiveness of biological nitrogen removal. Here, we review recent trends in carbon sources for nitrogen removal during wastewater treatment. A bibliometric analysis, using the Science Citation Index Expanded database from the Web of Science, was performed to analyze articles published in this field from 2000 to 2019. The major points are the following: (1) the publications from China ranked 1st, followed by the USA and Japan during the statistical period. In terms of research institutions, the Chinese Academy of Sciences was the largest contributor with the most publications. (2) Based on the trend analysis of keywords, future research hotspots are discussed, showing that of the related research on external carbon sources, the research focus on traditional carbon sources (methanol, ethanol, etc.) has decreased. The research focused on alternative carbon sources, such as sludge hydrolytic acidification liquid, fermentation liquid of food waste, agricultural waste, and biodegradable polymers, has increased. (3) New nitrogen removal technologies without external carbon sources, such as anammox is becoming increasingly popular. (4) In the study of nitrogen removal, more attention is paid to the change in the microbial community, and the biological mechanism of nitrogen removal is discussed from a microscopic perspective.
Mapping the Forest Fire Risk Zones Using Artificial Intelligence with Risk Factors Data
Authors: Sevinç Volkan 
Published: January 2022

Abstract
Geographical information system data has been used in forest fire risk zone mapping studies commonly. However, forest fires are caused by many factors, which cannot be explained only by geographical and meteorological reasons. Human-induced factors also play an important role in occurrence of forest fires and these factors depend on various social and economic conditions. This article aims to prepare a fire risk zone map by using a data set consisting of nine human-induced factors, three natural factors, and a temperature factor causing forest fires. Moreover, an artificial intelligence method, k-means, clustering algorithm was employed in preparation of the fire risk zone map. Turkey was selected as the study area as there are social and economic varieties among its zones. Therefore, the forestry zones in Turkey were separated into three groups as low, moderate, and high-risk categories and a map was provided for these risk zones. The map reveals that the forestry zones on the west coast of Turkey are under high risk of forest fire while the moderate risk zones mostly exist in the southeastern zones. The zones located in the interior parts, in the east, and on the north coast of Turkey have comparatively lower forest fire risks.
A Patient With Femoral Osteitis Fibrosa Cystica Due To Hyperparathyroidism: A Case Report
Authors: Xu Xiaolong , Yang Cuiping , Lu Shengjun , Pei Hong , Chen Shunguang , Liao Quanming 
Published: January 2022

Abstract
Background: Osteitis fibrosa cystica is a rare benign, lytic bone lesion attributed to hyperparathyroidism. The high level of parathyroid hormone cause rapid bone loss.Case presentation: The patient is a 50-year-old male complaining of severe sustained pain of the right knee joint. Imaging studies were suspicious for a benign tumor of the right distal femur. Biopsy under CT guidance showed numerous osteoclast aggregation and hemosiderin deposition around the bone trabeculae. Blood tests disclosed significantly elevated parathyroid hormone, serum calcium, serum alkaline phosphatase. Parathyroid ultrasonography and CT scan showed a solid mass in front of the trachea at the thoracic entrance plane. After resection of the mass, the clinical symptoms were relieved and the radiological findings were significantly improved, which further confirmed the diagnosis.Conclusions: Metabolic diseases-associated bone lesions require a comprehensive diagnosis of multiple inspection items.An interprofessional team approach to the diagnosis and treatment of Osteitis fibrosa cystica will provide the best outcome.
Local Tsunamigenic Sources In Greece, Identified By Pattern Recognition
Authors: O.V Novikova , A.I. Gorshkov 
Published: January 2022

Abstract
This study is an attempt to determine potential tsunamigenic morphostructural nodes in mainland Greece using pattern recognition algorithms. The earthquakes that have produced local tsunamis in the region were confined to morphostructural nodes whose locations were found by morphostructural zoning. The recognition problem consisted in separating all nodes in the region into the tsunamigenic class and the non-tsunamigenic class based mainly on the geomorphologic parameters of the nodes. The data on tsunamigenic earthquakes in Greece for training the Cora-3 algorithm were taken from the GHTD global historical catalog of tsunamigenic events (http://www.ngdc.noaa.gov/hazard/tsu_db.shtml). The recognition procedure resulted in determining 27 tsunamigenic nodes, with most of these being situated in the southern tip of the Peloponnese Peninsula, as well as in the gulfs of Corinth and Patras. Three tsunamigenic nodes were identified in the area of the Malian Gulf on the Aegean coast of Greece. According to the relevant literature, most local tsunamis in Greece were initiated by submarine slides and slumps due to earthquakes. According to the characteristic geomorphologic features derived in this study, the tsunamigenic nodes are situated in settings of contrasting relief characterized by steep slopes. This favors submarine landslides when subjected to earthquake excitation. The results reported in this paper form a basis for developing a methodology to be used in long-term tsunami hazard assessment, supplying information on local potential tsunamigenic sources required for tsunami regionalization of coastal areas in Greece.
How Do People with Late Bedtimes use Social Media?
Authors: Wang Shixiong , Xu Yajuan , Tian Xianyun , Song Yu , Luo Yanyu , Zhu Mingmin 
Published: January 2022

Abstract
Background: The use of social media before bedtime usually results in late bedtimes, which is a prevalent cause of insufficient sleep among the general population of most countries. However, it is still unclear how people with late bedtimes use social media, which is crucial for adopting targeted behavior interventions to prevent insufficient sleep. Methods: In this study, we randomly selected 100000 users from Sina Weibo and collected all their posting through web crawling. The posting time was proposed as a proxy to identify nights on which a user stays up late. A text classifier and topic model were developed to identify the emotional states and themes of their posts. We also analyzed their posting/reposting activity, time-use patterns, and geographical distribution. Results: Our analyses show that habitually late sleepers express fewer emotions and use social media more for entertainment and getting information. People who rarely stay up late feel worse when staying up late, and they use social media more for emotional expression. People with late bedtimes mainly live in developed areas and use smartphones more when staying up late. Conclusion: This study depicts the online behavior of people with late bedtimes, which helps understand them and thereby adopt appropriately targeted interventions to avoid insufficient sleep.
Impact of Salvage Cytotoxic Chemotherapy on Prognosis in Patients with Recurrence After Radical Cystectomy: A Multi-Institutional Retrospective Study
Authors: Koguchi Dai , Matsumoto Kazumasa , Ikeda Masaomi , Taoka Yoshinori , Hirayama Takahiro , Murakami Yasukiyo , Utsunomiya Takuji , Matsuda Daisuke , Okuno Norihiko , Irie Akira , Iwamura Masatsugu 
Published: January 2022

Abstract
Background

In patients experiencing disease recurrence after radical cystectomy (RC) for bladder cancer, data about the impact of clinicopathologic factors, including salvage treatment using cytotoxic chemotherapy, on the survival are scarce. We investigated the prognostic value of clinicopathologic factors and the treatment effect of salvage cytotoxic chemotherapy (SC) in such patients.
Methods

In this retrospective study, we evaluated the clinical data for 86 patients who experienced recurrence after RC. Administration of SC or of best supportive care (BSC) was determined in consultation with the urologist in charge and in accordance with each patient’s performance status, wishes for treatment, and renal function. Statistical analyses explored for prognostic factors and evaluated the treatment effect of SC compared with BSC in terms of cancer-specific survival (CSS).
Results

Multivariate analyses showed that liver metastasis after RC (hazard ratio [HR]: 2.13; 95% confidence interval [CI]: 1.17 to 3.85; P = 0.01) and locally advanced disease at RC (HR: 1.92; 95% CI: 1.06 to 3.46; P = 0.03) are independent risk factors for worse CSS in patients experiencing recurrence after RC. In a risk stratification model, patients were assigned to one of two groups based on liver metastasis and locally advanced stage. In the high-risk group, which included 68 patients with 1–2 risk factors, CSS was significantly better for patients receiving SC than for those receiving BSC (median survival duration: 9.4 months vs. 2.4 months, P = 0.005). The therapeutic effect of SC was not related to a history of adjuvant chemotherapy.
Conclusions

The present study indicated the potential value of 1st-line SC in patients experiencing recurrence after RC even with advanced features, such as liver metastasis after RC and locally advanced disease at RC.
Transcutaneous Electrical Acupoint Stimulation (Teas) In The Treatment of Dry Eye Disease
Authors: Ren Xiaotong , Yang Jiarui , Yuan Hao , Zhang Rong , Li Xuemin 
Published: January 2022

Abstract
Purpose: To assess effectiveness and safety of the Transcutaneous Electrical Acupoint Stimulation (TEAS) treatment in alleviating symptoms and signs of dry eye disease (DED).Methods: Patients diagnosed with DED at the Peking University Third Hospital Eye Center from December 2020 to February 2021 were randomly assigned in a 1:1:1 ratio to 5mA, 3mA, or 0mA Group respectively. DED signs and symptoms were evaluated before and 30min after treatment. We compared the clinical improvement among the three groups and between each two groups. Results: A total of 63 patients were included. 5mA Group had best efficacy in all the signs and most of symptoms (P<0.05), and the symptoms scores in 3mA Group were also significantly improved after treatment except pain, watering and increased secretions (P<0.05). In the comparisons between before and after treatment between each two groups, 5mA Group showed greater improvement in the signs and most of symptoms than other two groups(P<0.05). In addition, 3mA Group had greater improvement than 0mA Group in the symptoms of asthenopia (P=0.018) and blurred vision (P=0.001). During the treatment, we hadn’t gotten any adverse events from patients.Conclusions: TEAS treatment was effective in the treatment of DED, and 5mA provided greater signs and symptoms relief. TEAS might be a new therapeutic option for the treatment of DED.
East Asian Monsoon Forcing And North Atlantic Subtropical High Modulation of Summer Great Plains Low-Level jet
Authors: Malloy Kelsey , Kirtman Ben P. 
Published: January 2022

Abstract
Dynamic influences on summertime seasonal United States rainfall variability are not well understood. A major cause of moisture transport is the Great Plains low-level jet (LLJ). Using observations and a dry atmospheric general circulation model, this study explored the distinct and combined impacts of two prominent atmospheric teleconnections – the East Asian monsoon (EAM) and North Atlantic subtropical high (NASH) – on the Great Plains LLJ in the summer. Separately, a strong EAM and strong western NASH are linked to a strengthened LLJ and positive rainfall anomalies in the Plains/Midwest. Overall, NASH variability is more important for considering the LLJ impacts, but strong EAM events amplify western NASH-related Great Plains LLJ strengthening and associated rainfall signals. This occurs when the EAM-forced Rossby wave pattern over North America constructively interferes with low-level wind field, providing upper-level support for the LLJ and increasing mid- to upper-level divergence.
Analysis of Influence Factors of Quality of Life of Lung Cancer Patients with Skin Adverse Drug Reactions Under Targeted Therapy
Authors: Du Ruofei , Wang Xin , Zhou Huiyue , Ma Lixia , Larcher Leon M. , Chen Changying , Wang Tao 
Published: January 2022

Abstract
Purpose

This study was to assess the status of quality of life and explore the possible factors correlated with quality of life among non-small cell lung cancer (NSCLC) patients with skin adverse drug reactions under targeted therapy.
Methods

We performed a cross-sectional study including 536 NSCLC patients with skin adverse drug reactions by targeted therapy in cancer outpatient clinics of three hospitals in China between May 2020 and May 2021. And we collected data with structured questionnaires and identified the relationships among coping style, self-management and quality of life by Pearson correlation analysis and multiple linear regression algorithm.
Results

The total score of quality of life was 46±12.84 in 536 NSCLC patients with skin adverse drug reactions undergoing targeted therapy. In multiple linear regression analysis, we identified the significant factors associated with quality of life including age, education level, combination of medicine, Charlson Comorbidity Index (CCI), stages of disease, facing, yield, symptom management, daily activity management, psychological and emotional management, self-efficacy and self-management (P < 0.05).
Conclusions

NSCLC patients with skin adverse drug reactions undergoing targeted therapy generally had a compromised quality of life. And the critical factors that affected the status of quality of life were age, education level, co-morbidity, the combinatorial application of drugs and stage of disease, self-management and coping styles.