bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with liver injury after intravenous gamma globulin treatment in children with Kawasaki disease
Authors: ZhiPeng Xu , Ren Yue , Yu Huan , Hang Biyao , Xia Yuhan , Li Jie , Wang Jianjie , Zhang Qihao , Zhao Xiaoshan , Chu Maoping 
Published: August 2022

Abstract
Background: The etiology of liver injury in children with Kawasaki disease(KD) is not yet clear.It is common for children who are responded to intravenous gamma globulin (IVIG) therapy to develop liver injury after IVIG treatment. This research is to explore related factors of liver injury after IVIG treatment in children with KD who responded retrospectively to IVIG.Methods: A total of 806 children with KD were included in this analysis. The clinical characteristics, laboratory findings, and drug use before IVIG were collected. Difference analysis, ROC curve analysis and logistic regression analysis were performed to obtain possible risk factors for liver injury after IVIG treatment.Results: Among the clinical symptoms of the two groups of children, children with lymphadenopathy had a lower risk of developing liver injury after IVIG treatment(p=0.040),while there were no significant differences in other symptoms. Among laboratory indicators, the liver injury group had higher levels of platelet(PLT),eosinophil(EO) and brain natriuretic peptide(BNP) levels and lower hemoglobin(HB),erythrocyte sedimentation rate(ESR) and prothrombin time(PT) levels before IVIG treatment (p<0.05).There were no significant difference in c-reactive protein(CRP) and Procalcitonin(PCT)(p>0.05).The use of antibiotics, dipyridamole and aspirin doses between two groups had statistically significant differences(p>0.05).Further ROC curve analysis of aspirin dose found the optimal cut-off point of aspirin was 34.7 mg/(k*d)(the 95% CI: 0.504-0.601,p=0.026).The logistic regression analysis showed high-dose aspirin (≥34.7mg/(kg*d))was a risk factor for liver damage after IVIG treatment in KD children. Further multivariate regression analysis prompted that the use of antibiotics and higher doses of aspirin(≥34.7mg/(kg*d))in the acute phase were independent risk factors for liver injury after IVIG treatment in children with KD(Antibiotic use: OR=2.195,95%CI:1.206-3.994,p=0.01;Aspirin use: OR=1.526,95%CI:1.083-2.151,p=0.016).Conclusions: For KD children with normal liver function in the acute phase, the younger the age of KD onset, the smaller the weight, the absence of lymphadenopathy, and more elevated PLT,EO, BNP, reduced HB,ESR and PT in acute stage, the more likely to develop liver injury after treatment. There was no significant correlation between the degree of systemic inflammation(levels of CRP and PCT)in the acute phase and liver damage after IVIG treatment. The use of antibiotics and high-dose aspirin in the acute phase may be the risk factors for liver function damage after IVIG treatment in KD children.
On the Singular Lowering Operator Du and Application to Connection Formulas
Authors: Sfaxi Ridha , Chefai Soumaya 
Published: August 2022

Abstract
In this paper, we establish an intertwining relation between the two singular lowering operators on polynomials Du and D−kδ, for every linear functional on polynomials u with canonical moment (u)0 = −k, for some integer k ≥ 1, (δ is the Dirac delta at point zero). We also build a Du-Appell polynomial sequence and we obtain the connection coefficients betweena Du-Appell polynomial sequence and the canonical basis. As application, we prove that the singular Laguerre-Hahn polynomial sequence with class zero of Hermite type is Du-Appell with (u)0 = −1. Finally, a new connection formulas between the Hermite polynomials and the singular Laguerre-Hahn polynomial sequence with class zero of Hermite type is obtained.
Regulation of CD8+ T cells infiltration and immunotherapy by circMGA/HNRNPL complex in bladder cancer
Authors: Zhang Xiaoping , Sun Jiayin , Zhang Hui , Wei Wenjie , Xiao Xingyuan , Huang Chao , Wang Liang , Zhong He , Jiang Yangkai , Zheng Fuxin , Yang Hongmei , Jiang Guosong 
Published: August 2022

Abstract
The limited success of immunotherapies targeting immune checkpoint inhibitors is largely ascribed to the lack of infiltrating CD8+ T lymphocytes. Circular RNAs (circRNAs) are a novel type of prevalent noncoding RNA that have been implicated in tumorigenesis and progression, while their roles in modulating CD8+ T cells infiltration and immunotherapy in bladder cancer have not yet been investigated. Herein, we uncover circMGA as a tumor-suppressing circRNA triggering CD8+ T cells chemoattraction and boosting the immunotherapy efficacy. Mechanistically, circMGA functions to stabilize CCL5 mRNA by interacting with HNRNPL. In turn, HNRNPL increases the stability of circMGA, forming a feedback loop that enhances the function of circMGA/HNRNPL complex. Intriguingly, therapeutic synergy between circMGA and anti-PD-1 could significantly suppress xenograft bladder cancer growth. Taken together, the results demonstrate that circMGA/HNRNPL complex may be targetable for cancer immunotherapy and the study advances our understanding of the physiological roles of circRNAs in antitumor immunity.
Effects of transfusing older red blood cells on patient outcomes in critical illness: a retrospective cohort study
Authors: Obonyo Nchafatso G. , Sela Declan P. , White Nicole , Tunbridge Matthew , Sim Beatrice , Hoe Louise E. See , Bassi Gianluigi Li , Fanning Jonathon P. , Tung John-Paul , Suen Jacky Y. , Fraser John F. 
Published: August 2022

Abstract
Randomised controlled trials have demonstrated critically ill patients do not benefit from receiving fresh (<7 days old) packed red blood cells (pRBCs), however there is limited evidence regarding transfusion with pRBCs nearing expiry (35-42 days). In this retrospective observational study, we analysed data obtained from 7-years of centralised electronic medical records (2007–2013), sourced from hospitals in the Australian state of Queensland, to investigate whether transfusion with pRBCs nearing expiry contributed to increased morbidity and mortality in critically ill patients. 10,350 critically ill adults (>12 years) patients transfused ≥1 unit of non-irradiated pRBCs (64,594 pRBCs units transfused) were included in this study. Receiving at least 1-unit pRBCs ≥35 days old was associated with increased mortality (OR 1.21 [95% CI 1.06–1.38]; p=0.005), decreased discharge to usual residence (OR 0.81 [95% CI 0.73–0.89]; p<0.0001) and increased hospital LOS (Estimate 2.55 [95% CI 1.60–3.49]; p<0.0001). There was also association with increased sepsis (OR 1.27 [95% CI 1.13–1.42]; p<0.0001) and delirium (OR 1.25 [95% CI 1.06–1.49]; p=0.01).Transfusion of ≥1-unit pRBCs ≥35 days old was associated with evidence of increased mortality and morbidity in critically ill patients. Further prospective studies are required to validate findings and overcome limitations of retrospective analysis.
Macroeconomic Factors and the Prospects of Economic Prosperity in a Developing Economy: Evidence from Dynamic ARDL Simulations and KRLS Techniques
Authors: Aladejare Samson Adeniyi 
Published: August 2022

AbstractPolicymakers have continued to be fascinated with the combinations of macroeconomic indicators that can drive long-term wealth in different countries. Consequently, this study investigated the effects of inflation and exchange rates, deficit financing, foreign investment, and financial development on economic prosperity measured by GDP per capita for Nigeria from 1970 to 2020. Empirical inferences were derived by applying the autoregressive distributed lag (ARDL), dynamic ARDL (DYNARDL), and the Kernel-based regularised least squares (KRLS) models. It was observed that inflation rate and deficit financing adversely impacted economic wealth in the short and long term. At the same time, the exchange rate and financial development only benefited economic prosperity in the long term. In contrast, foreign investment was reported to be prosperity-decelerating in the long term. Applying the DYNARDL and KRLS techniques enabled the response of economic prosperity to future counterfactual shocks to the inflation and exchange rate variables. While inflationary shocks may have long-term beneficial effects on economic prosperity, shocks to the exchange rate will slightly erode these benefits. The study proposed several policy measures.
Resistin promotes nasopharyngeal carcinoma metastasis through TLR4-mediated activation of p38 MAPK/NF-κB signaling pathway
Authors: Zhang Zongmeng , Du Jinlin , Xu Qihua , Li Yuyu , Zhou Sujin , Zhao Zhenggang , Mu Yunping , Zhao Allan Zijian , Cao Sumei , Li Fanghong 
Published: August 2022

Abstract
Background
Nasopharyngeal carcinoma (NPC) is a malignant tumor with a high risk of local invasion and early distant metastasis. Resistin is an inflammatory cytokine predominantly produced from the immunocytes in humans. Accumulating evidence suggested clinical association of circulating resistin with the risk of tumorigenesis, the relationship between blood resistin levels and the risk of cancer metastasis. In this study, we explored the blood levels and the role of resistin in NPC.
Methods
A hospital-based case control study was used to assess the association of circulating resistin level with the risk of NPC and clinicopathological characteristics. Wound-healing and Transwell assays were applied to confirm the effects of resistin on NPC cell invasion and migration. A mouse model for lung metastasis was used to explore the role of resistin in NPC tumor metastasis. We also investigated the underlying signaling mechanisms with various specific pharmacological inhibitors and biochemistry analysis.
Results
High resistin levels in NPC patients positively association with lymph node metastasis, and resistin promoted the migration and invasion of NPC cells in vitro. These findings were also replicated in the mouse model of NPC tumor metastasis. We further showed that activation of p38 MAPK pathway was critical for resistin-induced migration and invasion through interaction with TLR4 with NF-κB as the primary mediator of resistin induced epithelial-mesenchymal transition in NPC cells.
Conclusion
Taken together, our results suggests that resistin promotes NPC metastasis through activating the TLR4/p38 MAPK/NF-κB signaling pathway.
Simultaneous space and phase resolved X-ray
polarimetry of the Crab Pulsar and Nebula
Authors: Bucciantini Niccolò 
Published: August 2022

Abstract
The Crab pulsar and its nebula are among the most studied astrophysical systems, and constitute one of the most promising environments where high energy processes and particle acceleration can be investigated. They are the only objects for which previous X-ray polarisation has been reported. We present here the first Imaging X-ray Polarimetry Explorer (IXPE) observation of the Crab pulsar and nebula. The total pulsar pulsed emission in the [2–8] keV energy range is unpolarised. Significant polarisation up to 15% is detected only in the core of the main peak. The nebula has a total space integrated polarised degree of 20% and polarisation angle of 145◦. The polarised maps show a large level of asymmetry, and regions with polarised degree up to 45-50%. The polarisation pattern suggests a predominantly toroidal magnetic field.
Forced Social Isolation and Lockdown during the COVID-19 Pandemic: Depression, Anxiety, and Trauma-distress in a Greek sample
Authors: LIOZIDOU ATHANASIA , VARELA VASILIKI , VLASTOS DIMITRIOS , GIOGKARAKI ERASMIA , ALZUETA ELIZABET , PERRIN PAUL , RAMOS-USUGA DANIELA , ARANGO-LASPRILLA JUAN CARLOS 
Published: August 2022

Abstract
Purpose
The COVID-19 outbreak escalated into a global pandemic, forcing governments around the world to impose measures affecting all aspects of life. Like other countries, Greece adopted social restriction, lockdowns, and quarantines to reduce transmission from person-to-person. This cross-sectional study investigated the impact of social restriction measures on mental health in a Greek adult sample.
Method
An online questionnaire collected data during the second national lockdown (February to May 2021). A total of 650 participants (M age: 33.13, 71.5% female) comprised the final sample.
Results
21.3% of respondents reported moderate-to-extremely severe anxiety, 33% moderate-to-extremely severe depression, 31.8% moderate-to-severe stress, and 38% clinically significant trauma-related distress. Hierarchical linear regression analyses revealed that the strongest contributors to adverse mental health outcomes were being female, younger age, experiencing increases in verbal arguments at home, being separated from family and close friends, and being unable to afford enough or healthy food. Lastly, participants moved away from social support and into more individual strength and resilience-based coping strategies to cope with challenges.
Conclusion
These findings suggest that in addition to the detrimental effects on physical health, COVID-19 also imposed a heavy psychological burden on the population via forced social isolation, which, by design, increased not only physical distancing but also psychological distancing between people.
Evaluation of On-Board Sensor-Based NOx emissions from the heavy-duty vehicles in an inspection and Maintenance program
Authors: Li Chengguo , Ma Tianyi , Karavalakis Georgios , Johnson Kent C , Durbin Thomas D 
Published: August 2022

Abstract
Heavy-duty diesel vehicles (HDDVs) are important sources of urban nitrogen oxides (NOx) in an actual application for environmental compliance. The remote on-board sensing (OBS) is a cost-effective emission reduction approach for HDDVs. NOx emissions from fifty-four sediment hauling trucks were evaluated in a construction area and this information was utilized to make changes to the hauling trucks being used on the project. Approximately1/3 of the trucks had emissions that were comparable to or below 0.2 g/bhp-hr level. The fleet average NOx emissions were 0.38 g/bhp-hr for non-credit engines and 0.77 g/bhp-hr for credit engines, with 2013 and newer credit engines averaging 0.29 g/bhp-hr. The overall NOx conversion efficiencies of the selective catalytic reduction (SCR) system on many vehicles were in the 80–90%, and SCR efficiencies for some high emitter vehicles were down to approximately 60%. This is due to high engine operation fractions at the lowest SCR inlet temperature zone (> 200 ℃). This study also found that the NOx emissions for non-2010-2012 Family Emission Limit (FEL) trucks were well below the California Clean Idle certification of 30 g/hour. Recommendation was provided to efficiently maintain the emission levels in the reservoir.
Flexural Performance of Reinforced Concrete (RC) Beam Strengthened by UHPC Layer
Authors: Mirdan Dhafer , Saleh Abdul Ridah 
Published: August 2022

Abstract
Reinforced concrete (RC) structures may be subjected to an increase in load, severe environmental attack, and other factors that may lead to deterioration. Strengthening/repair techniques are typically used to upgrade the strength or enhance the durability which extends the service life of the structures. In the current study, the behavior of reinforced concrete beam strengthening by the UHPC layer with/without construction joints was investigated. The effect of the steel/GFRP bars across the construction joints was also performed and the results were compared with control specimens. The results indicate that the inclusion of UHPC layers at the tensile side of the RC beams significantly increased their stiffness and delayed the crack initiation. Meanwhile, the presence of the construction joint in the UHPC overlay decreased the efficiency of the strengthening method. Furthermore, utilizing steel /GFRP bar in UHPC overlay across the construction joints showed a significant increase in loading carrying capacity and had a significant effect on the modes of failure. The results also demonstrated that the UHPC overlay experienced a sufficient bond to concrete as no separation was observed.
Early life histories of Great Moravian children – carbon and nitrogen isotopic analysis of dentine serial sections from the Early Medieval population of Mikulčice (9th-10th centuries AD, Czechia)
Authors: Kaupová Sylva Drtikolová , Brůžek Jaroslav , Hadrava Jiří , Mikšík Ivan , Morvan Marine , Poláček Lumír , Půtová Lenka , Velemínský Petr 
Published: August 2022

Abstract
In order to compare the early life experiences of different population subgroups from the Early Medieval centre of Mikulčice, carbon and nitrogen isotopic values were measured in dentine serial sections from the first permanent molar of 78 individuals. Age-at-death, sex (estimated in subadults with the help of proteomics) and socio-economic status were considered as explicative variables. Average values of both nitrogen and carbon maximal isotopic offset within the isotopic profile were higher than the recommended range for weaning under healthy circumstances: 3.1 ± 0.8‰ for Δ15Nmax and 1.6 ± 0.8‰ for Δ13Cmax. Individuals who died during the first decade of life showed earlier ages at the final smoothing of the nitrogen isotopic curve (suggesting complete weaning) than older individuals. Most individuals (n = 43) showed positive covariance between δ15N and δ13C values during the period of breastfeeding. The average δ15N values from the post-weaning period were similar to those of bone, while post-weaning δ13C values were significantly higher. Though an increased Δ15Nmax suggests a common presence of physiological stress, the intra-population comparison of early life experiences does not suggest that individuals who died during their first decade experienced greater levels of environmental stress during infancy. The predominance of positive covariance between carbon and nitrogen isotopic values during the breastfeeding period, together with an increased Δ13Cmax and increased post-weaning δ13C, suggest that millet was either a part of a special diet preferred during lactation or was introduced as a first dietary supplement.
Sequential Correction Using Satellite Rod for the Treatment of Severe Rigid Spinal Deformity: A Retrospective Study of 19 Cases
Authors: Yin Huipeng , Wang Kun , Li Shuai , Song Yu , Feng Xiaobo , Hua Wenbin , Wu Xinghuo , Zhang Yukun , Yang Cao 
Published: August 2022

Abstract
Objective: The aim of this study was to access the efficacy of sequential correction using satellite rod in patients with severe rigid spinal deformity undergoing posterior-only PVCR.Methods: 19 patients with severe rigid spinal deformity who underwent PVCR at our center from January 2014 to December 2019 were reviewed. Radiographic measurements, including major coronal Cobb angle, kyphotic curve angle, coronal and sagittal balance were measured. Clinical outcomes, including Oswestry Disability Index score, SRS-22 questionnaire, and complications were recorded.Results: Total 19 patients were followed at least 2 years. The mean coronal Cobb angle was decreased from 122.7° ± 13.17° to 57.89° ± 8.65° postoperatively, and to 58.42° ± 8.98° at final follow-up. Correction rate is 52.8%. The kyphotic curve angle improved from 102.2° ± 17.05° preoperatively to 39.68° ± 13.67° postoperatively, and to 37.74° ± 12.14° at final follow-up. Correction rate is 61.2%. The apex vertebral translation, ODI and SRS-22 scores were improved significantly at the final follow-up compared with preoperative.Conclusions: Sequential correction with auxiliary satellite rod can effectively reduce the surgical difficulty and achieve a well deformity correction rate for patients with severe rigid spinal deformity.
Antibody response to variants during Omicron outbreak after BNT162b2 booster in Korean healthcare workers
Authors: Lim Sung Hee , Kim Han Jo , Kim Se Hyung , Choi Seong Hyeok , Kim Bora , Kim Ji Youn , Ji Young Sok , Kim Tark , Choo Eun Ju , Jung Jung Chan , Kim Chan Kyu , Park Seong Kyu , Yun Jina 
Published: August 2022

Abstract
In South Korea, the booster shot for COVID-19 was carried out amid concerns about the effectiveness of the existing vaccine. The virus neutralization test (sVNT) inhibition (%) score for the wild-type and delta variant significantly and uniformly increased (97%, 98%; p < 0.001) but it was decreased for the omicron after the BNT162b2 booster dose (75%; p < 0.001). In 41 HCWs (39.0%), infected with the omicron, no difference in immunogenicity, adverse events, and effectiveness between homogeneous and heterogeneous boosters were observed. In cohort 2, 58 HCWs included, at the fourth month of the booster dose, sVNT inhibition to omicron was significantly increased in the omicron-infected group (95.13%) compared to the non-omicron-infected (mean of 48.44%; p < 0.001). It is difficult to respond to the current vaccines to the Omicron variant adequately. Developing a variant-response vaccine should be prioritized, especially for the additional vaccination for HCW or previously infected persons.
Diagnostic and prognostic nomograms for Distal Metastasis in Intrahepatic cholangiocarcinoma: A SEER-Based Study
Authors: Nie Guole , Yan Jun , Zhang Honglong , Zhu Xingwang , Li Xun 
Published: August 2022

Abstract
Background and objectives: Intrahepatic cholangiocarcinoma (ICC) is a malignant tumor originating from the bile duct epithelium above the confluence of the left and right hepatic ducts, in which distant metastases (DM) continue to result in a worse prognosis. This study systematically extracted the clinical-pathological data for ICC patients from the Surveillance, Epidemiology, and End Results (SEER) database, aiming to detect prognostic and predictive factors for DM in ICC patients and to generate two nomograms to assess the DM risk and prognosis in patients with ICC.Methods: From 2010 to 2015, the SEER database was used to extract clinical and treatment information of individuals with a pathological diagnosis of ICC. Multivariate and univariate logistic analyses were assessed to detect the risk factors related to the occurrence of DM in patients with ICC. Multivariate and univariate analyses of Cox regression were assessed to detect prognostic risk factors for DM in ICC patients, and two nomograms were formed.Results: This study included 2089 participants with ICC. Stage T, stage N, and gender were all risk factors that are related to the development of DM in ICC patients. Age, gender, stage T, surgery, and chemotherapy were found to be related prognostic factors in individuals with ICC who had DM. Among the training group, the area under the curve (AUC) for the diagnostic nomogram was 0.705, and the AUC was 0.670 in the testing group. At 6, 9, and 12 months, the AUCs for the prognostic nomogram were 0.778, 0.759, and 0.721 in the training group, and 0.792, 0.755, and 0.730 in the testing group, respectively. The calibration curves and decision curve analysis (DCA) showed that the two nomograms have good calibrate performance and clinic clinical application values. Finally, the Kaplan-Meier (K-M) curves showed a significant difference in prognostic survival between patients in the high-risk and low-risk groups.Conclusion: Based on the SEER database we successfully constructed two nomograms for assessing the risk of DM in ICC patients and the prognosis of ICC patients with DM, which will assist clinicians in decision-making and personalized clinical care.
Exceptionally robust magnetism and structure of SrFeO2 above 100 GPa
Authors: Balédent Victor , Nataf Lucie , Rueff Jean-Pascal 
Published: August 2022

Abstract
We report the exceptional structural and magnetic stability of SrFeO2 under pressure by X-Ray Magnetic Circular Dichroism (XMCD) and X-ray Diffraction (XRD) up to the Mbar range. The XMCD data confirms the onset of ferromagnetism above 30 GPa and its stability up to 102 GPa while XRD shows that SrFeO2 structure remains unchanged from 30 GPa up to 111 GPa without any sign of structural transition. Our results demonstrate the robustness of Fe properties under extreme conditions in the square planar environment.