bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERAN BADAN PERMUSYAWARATAN DESA DALAM PEMBUTAN ATURAN PENCEGAHAN COVID-19 DI DESA KALIWEDI KIDUL
Authors: Rahman Nur , Fadhli Harun , Sarip Sarip , Giyono Urip , Multahibun Multahibun 
Published: September 2022

This study has two issues of study in its discussion, the first is a study that is directed to find out and analyze the duties, functions and authorities of the Village Consultative Body (BPD) from the point of view of positive law in Indonesia, and secondly, this study will also discuss how the role and implementation of BPD functions in overcoming and preventing the spread of Covid-19 in their respective villages. This research is a juridical-empirical research that tries to explain the role of BPD in a predetermined research location, namely in Kaliwedi Kidul Village, Kaliwedi District, Cirebon Regency, this study uses primary data as the main data, the primary data as intended by the author is obtained through the data collection techniques used with unstructured observations and interviews, the results of the study show that legally the BPD has a function, namely the legislative function at the village level, the BPD and the village head have an obligation to make a policy in the form of village regulations, however, in Kaliwedi Village, the implementation of this function has not been able to implemented optimally, especially when it is associated with the formation of village regulations concerning the issue of preventing the spread of Covid-19, so it is necessary that in the future BPD can cooperate with village heads, to make policies to overcome Covid-19 in their villages, this is important so that prevention the spread of Covid-19 can have a strong legal basis down to the village level.
Keywords: BPD Function, Village Regulation, Covid-19 Prevention
KEWAJIBAN DINAS ATAS PUTUSAN KOMISI INFORMASI PUBLIK TERHADAP KELENGKAPAN DOKUMEN PUBLIK DI KABUPATEN CIREBON
Authors: Suhardi Heri - , Sarip Sarip 
Published: September 2022

This study aims to find out how the obligations of the Cirebon Regency Education Office on the decision of the Cirebon Regency Regional Information Commission Number 002/VI/KIKC-PS-A/2018 on the completeness of public documents in Cirebon Regency. The form of the completeness of the requested public documents in the form of a request for a hardcopy / official copy of the 2017 Budget Implementation Document at the Cirebon Regency Education Office is open information based on the KIP Law. The obligation of the Cirebon Regency Education Office in accordance with its duties and functions as a Public Agency does not carry out the mandate of the KIP Law. The methodology used is a type of normative juridical research, namely legal research that places the law as a building system of norms. The system of norms in question is to recognize the principles, norms, rules of laws and regulations, court decisions, agreements and doctrines (teachings). Meanwhile, from the nature of the core research, it is included in the type of descriptive research in the form of diagnostic and evaluative by using qualitative exposure. The findings in this study, First; the weak response and no guarantees as well as the existence of deliberate institutional actions by the Cirebon Regency Education Office, so that the rights of applicants for public information are ignored so that they must take the public information dispute resolution route at the Cirebon Regency Regional Information Commission. Second; that the obligation of the Cirebon Regency Education Office is not to provide, not to provide and/or not to publish public information under its authority to applicants for public information until an unspecified time limit, so that unclear public information will appear and cause a problem.
Keywords: Obligations of Public Bodies, Decisions on Information Disputes and UU KIP.
UMA ANÁLISE SOBRE A PRECARIZAÇÃO DO TRABALHO A PARTIR DA EMPRESA-APLICATIVO UBER.
Authors: Brandão Raquel Lins , Da Ponte Karina Furini 
Published: September 2022

RESUMOEste artigo tem como objetivo realizar uma discussão sobre a precarização dos trabalhadores por aplicativo vinculados à empresa Uber. Para isso, partimos de uma reflexão sobre a centralidade do trabalho e sua relação com a ciência geográfica, o que proporcionou realizamos uma análise das transformações sofridas no mundo do trabalho a partir da crise do capital da década de 1970 e, de seu processo de reestruturação produtiva e flexibilização das relações e formas de gestão do trabalho. Como metodologia partiu-se de leituras e sistematizações de obras para entender o capitalismo, e a crescente degradação do trabalho, buscando apontar como isso afeta os trabalhadores cotidianamente, além de textos, artigos e reportagens sobre a empresa-aplicativo Uber. Portanto, foi possível identificar as formas de precarização do trabalhador vinculado à empresa Uber, seu controle pelo algoritmo e também desmistificar o caráter de “empreendedor” propagado pela empresa. Palavras Chave – Capital; Trabalho; Uber.
MITIGASI UNTUK MENGHADAPI ANCAMAN BENCANA AKIBAT KEGAGALAN TEKNOLOGI NUKLIR DI REAKTOR SERBA GUNA GERRIT AUGUSTINUS SIWABESSY
Authors: Meiliasari Dewi Prima , Panjaitan Berton Suar , Widana I Dewa Ketut Kerta 
Published: September 2022

RSG-GAS has a fairly large thermal power of 30 megawatts, besides being useful for health, industry, research, it also has a potential radioactive releases nearby to the Serpong Nuclear Area about a 5 km radius. The existence of the RSG-GAS in the administrative area of South Tangerang City based on the 2019 Disaster Risk Index has a high risk class for earthquakes and extreme weather, as well as population growth that continues to increase within a radius of 1 km from RSG-GAS, resulting in external hazards from outside the RSG-GAS becoming a threat. in the operation of the RSG-GAS. To be able to reduce potential risk, structural and nonstructural mitigation efforts are needed. This study aims to analyze structural and nonstructural mitigation in the RSG-GAS. The research method used was qualitative with exploratory descriptive research design. The results of the study indicate that structural mitigation has begun to be carried out on the evaluation of site characteristics from the determination of prospective sites to the operation stage for internal and external hazards, the evaluation results are taken into consideration in the design of the RSG-GAS. The RSG-GAS design is capable of both internal and external hazards. Early detection systems can reduce the risk of disaster due to failure of nuclear technology. Nuclear emergency training has been carried out and it is necessary to coordinate the preparation of nuclear preparedness programs at the provincial and national levels. In conclusion, a chain of mitigation efforts has been executed in RSG-GAS in relation to the 2020-2024 National Plan on Disaster Management in order to support the national security.
CASOS DE INTOXICAÇÃO POR AGROTÓXICOS EM MALEICULTORES E ANÁLISE DOS RESPECTIVOS PRONTUÁRIOS DE ATENDIMENTO
Authors: Da Cruz Nogueira Tiago , Vassem de Oliveira Simone , Morello Larissa , Scherer de Oliveira Kelly , Da Silva Bruna Fernanda , Siegloch Ana Emília , Agostinetto Lenita 
Published: September 2022

Atualmente, o Brasil é líder mundial no consumo de agrotóxicos. O aumento do uso e manuseio desses produtos químicos pode provocar o aumento nos casos de intoxicações humanas, oferecendo risco à saúde do trabalhador rural e ao próprio ambiente. A expansão crescente da agricultura na Região da Serra Catarinense provoca o consequente incremento do uso de agrotóxicos, que pode culminar com o aumento dos casos de intoxicações e colocar em risco à saúde do trabalhador rural. O objetivo desse estudo foi levantar possíveis casos de intoxicação por agrotóxicos em maleicultores de um município da Serra Catarinense e comparar as informações coletadas com seus respectivos prontuários de atendimento médico na Unidade Básica de Saúde (UBS) que atende a região estudada. Foram entrevistados 66 maleicultores dos quais 11 manifestaram intoxicação por agrotóxicos. Os resultados demonstraram que os indivíduos que informaram ter sofrido intoxicação por agrotóxicos apresentaram no mínimo dois sintomas, sendo que os mais comuns foram cefaleia e irritação da pele, relacionados principalmente, ao uso de Mancozebe, Fenitrotiona e Difenoconazol. Na UBS, Foram encontrados quatro prontuários referentes a esses indivíduos, entretanto em nenhum deles o diagnóstico foi descrito como intoxicação, apesar de alguns sintomas descritos no prontuário remetessem a sintomas de intoxicação por agrotóxicos. Conclui-se que há casos de intoxicação na região, entretanto, os respectivos prontuários de atendimento não associam o caso à intoxicação por agrotóxicos.
Investigating the anticancer efficacy of biogenic synthesized MgONPs: An in vitro analysis
Authors: Tabrez Shams , Khan Azhar U. , Hoque Mehboob , Suhail Mohd , Khan Mohammad Imran , Zughaibi Torki A. 
Published: September 2022

The biogenic approach of synthesizing metal nanoparticles is an exciting and interesting research area with a wide range of applications. The present study reports a simple, convenient, low-cost method for synthesizing magnesium oxide nanoparticles (MgONPs) from pumpkin seed extracts and their anticancer efficacy against ovarian teratocarcinoma cell line (PA-1). The characteristic features of biogenic MgONPs were assessed by UV–visible spectrophotometry (UV–vis), X-ray powder diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The formation of spherical NPs with an average size of 100 nm was observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Moreover, MgONPs exhibit considerable cytotoxicity with an IC50 dose of 12.5 μg/ml. A dose-dependent rise in the induction of apoptosis, ROS formation, and inhibition in the migration of PA-1 cells was observed up to 15 μg/ml concentration, reflecting their significant anticancer potential against ovarian teratocarcinoma cell line. However, additional work, especially in different in vitro and in vivo models, is recommended to find out their real potential before this environment-friendly and cost-effective nanoformulation could be exploited for the benefit of humankind.
Immunological response and temporal associations in myocarditis after COVID-19 vaccination using cardiac magnetic resonance imaging: An amplified T-cell response at the heart of it?
Authors: Vago Hajnalka , Szabo Liliana , Szabo Zsofia , Ulakcsai Zsuzsanna , Szogi Emese , Budai Gizella , Toth Attila , Juhasz Vencel , Dohy Zsofia , Hoffer Krisztina , Becker David , Kiss Robert Gabor , Nagy Gergely Gyorgy , Nagy Gyorgy , Merkely Bela 
Published: September 2022

IntroductionAlthough myocarditis after anti-SARS-CoV-2 vaccination is increasingly recognized, we have little data regarding the course of the disease and, consequently, the imaging findings, including the tissue-specific features. The purpose of this study is to describe the clinical, immunological, and cardiac magnetic resonance (CMR) features of myocarditis after COVID-19 immunization in the acute phase and during follow-up. We aimed to compare the trajectory of the disease to myocarditis cases unrelated to COVID-19.MethodsWe assembled a CMR-based registry of potentially COVID-19 vaccination-related myocarditis cases. All patients who experienced new-onset chest pain and troponin elevation after COVID-19 vaccination and imaging confirming the clinical suspicion of acute myocarditis were enrolled in our study. Participants underwent routine laboratory testing and testing of their humoral and cellular immune response to COVID-19 vaccination. Clinical and CMR follow-up was performed after 3–6 months. We included two separate, sex- and age-matched control groups: (1) individuals with myocarditis unrelated to COVID-19 infection or vaccination confirmed by CMR and (2) volunteers with similar immunological exposure to SARS-CoV-2 compared to our group of interest (no difference in the number of doses, types and the time since anti-SARS-CoV-2 vaccination and no difference in anti-nucleocapsid levels).ResultsWe report 16 CMR-confirmed cases of myocarditis presenting (mean ± SD) 4 ± 2 days after administration of the anti-SARS-CoV-2 vaccine (male patients, 22 ± 7 years), frequently with predisposing factors such as immune-mediated disease and previous myocarditis. We found that 75% received mRNA vaccines, and 25% received vector vaccines. During follow-up, CMR metrics depicting myocardial injury, including oedema and necrosis, decreased or completely disappeared. There was no difference regarding the CMR metrics between myocarditis after immunization and myocarditis unrelated to COVID-19. We found an increased T-cell response among myocarditis patients compared to matched controls (p &lt; 0.01), while there was no difference in the humoral immune response.ConclusionIn our cohort, myocarditis occurred after both mRNA and vector anti-SARS-CoV-2 vaccination, frequently in individuals with predisposing factors. Upon follow-up, the myocardial injury had healed. Notably, an amplified cellular immune response was found in acute myocarditis cases occurring 4 days after COVID-19 vaccination.
Geological occurrence and productivity prediction for coalbed methane of central Hunan depression, China
Authors: Cai Ningbo , Wang Keying , Du Jiang 
Published: September 2022

To analyze the geological occurrence and predict the drainage performance of coalbed methane in the central Hunan depression of China, coal samples were collected to conduct physical experiments and numerical simulations. The following conclusions were reached. The vitrinite ranges from 54.37 to 87.80%, the inertinite is between 11.14–25.89%, and exinite is less than 1%. The inorganic components are mainly clay minerals and vary from 0.71 to 5.66%. The major porosity ranges from 7 to 9%, and it is influenced by organic/inorganic components and maturity. Both the vertical and horizontal permeabilities are at a relatively low level, mostly below 0.05 mD, indicating the reservoir is low permeable or non-permeable. The reservoir pressure ranges from 3.74 to 11.58 MPa, which has significant and positive linear correlations with closure pressure and burial depth. Gas content varies from 5 m3/t to 20 m3/t. The theoretical recovery ratio in the Hongshandian mining area is about 61.7%, while the values of the two spots in the Duanpiqiao mining area are 49.1 and 54.5%. Production predictions show that under the permeability of 0.01 mD, 0.05 mD, and 0.10 mD, cumulative gas productions in 10 years for a single well range from 1.7 × 106 m3 to 3.2 × 106 m3, and those for a well group consisting of five wells vary from 10.5 × 106 m3 to 19.2 × 106 m3. Thus, this area will have a high value for coalbed methane exploitation after stimulating the reservoir to increase permeability successfully.
Maternal lipid profile during early pregnancy and birth weight: A retrospective study
Authors: Zhu Si-Meng , Zhang Han-Qiu , Li Cheng , Zhang Chen , Yu Jia-Le , Wu Yan-Ting , Huang He-Feng 
Published: September 2022

IntroductionElevated maternal serum lipid concentrations have been related to an adverse intrauterine environment and lead to abnormal birth weight.ObjectiveIn this study, we aimed to explore the association between maternal lipid profiles during early pregnancy and birth weight with stratified pre-pregnancy body mass index (BMI).MethodsThis retrospective cohort study was based on a large population from two major maternity centers in Shanghai, China. We included 57,516 women with singleton live birth between January 2018 and October 2020. All of the enrolled women had fasting lipid concentrations measured in early pregnancy. The primary outcomes were birth weight and risks of adverse birth outcomes, including macrosomia, large for gestational age (LGA), low birth weight (LBW), and small for gestational age (SGA).ResultsHigher maternal concentrations of total cholesterol (TC), triglyceride (TG), and low-density cholesterol (LDL-c) in early pregnancy were associated with increased birth weight. Ln transformed TG and levels exhibited a positive association with LGA and macrosomia (OR = 1.33, 95% CI: 1.25, 1.42 and OR = 1.37, 95% CI: 1.24, 1.52) and showed a negative relationship with SGA (OR = 0.73, 95% CI: 0.62, 0.85). High TG (&gt;75th percentile, 1.67 mmol/L) group also showed higher risks of LGA and macrosomia (OR = 1.21, 95% CI: 1.15, 1.28 and OR = 1.20, 95% CI: 1.10, 1.31) and decreased prevalence of SGA (OR = 0.71, 95% CI: 0.61, 0.83). Moreover, significant combined effects of pre-pregnancy BMI and lipid profiles on LGA and macrosomia were identified.ConclusionsElevated maternal lipid profiles in early pregnancy are associated with higher birth weight and increased risks of LGA and macrosomia. We propose that serum lipid profiles in early pregnancy and pre-pregnancy BMI could serve as screening indexes for high-risk women.
The associations of muscle mass with glucose and lipid metabolism are influenced by body fat accumulation in children and adolescents
Authors: Gao Liwang , Cheng Hong , Yan Yinkun , Liu Junting , Shan Xinying , Wang Xi , Mi Jie 
Published: September 2022

ObjectiveTo evaluate the prevalence of hyperglycemia and dyslipidemia among different body composition and investigate the associations of body composition indicators, especially the muscle mass, with glucose and lipids metabolism in children and adolescents.MethodsThis nationwide cross-sectional study included 8,905 children and adolescents aged 6 to 18 years. All participants underwent dual-energy x-ray absorptiometry and their blood-concentrated glucose and lipids (including TC, TG, LDL-C and HDL-c) were measured. Mixed model, hierarchical analysis, and piecewise regression were used to study the effect of body composition indicators, especially the muscle mass, on glucose and lipids metabolism.ResultsThe greatest prevalence of high total cholesterol (TC, 6.9% and 6.9%) and high triglyceride (22.3% and 6.6%) was found in both boys and girls with high muscle mass and high fat mass, and girls with high muscle mass and high fat mass also had the highest prevalence of hyperglycemia (7.1%). After fat stratification, higher muscle mass was associated with lower odds of hyperglycemia (OR = 0.62; 95%CI: 0.46,0.84; P = 0.002) and muscle mass was inversely associated with TC (β = −0.07; 95%CI: -0.12,-0.03; P &lt; 0.001) in boys with normal fat mass, but high muscle mass was not significantly associated with hyperglycemia and TC in high-fat-mass group (P = 0.368 and 0.372).ConclusionsThe body composition phenotype of high muscle and high fat mass have the highest prevalence of dysglycemia and dyslipidemia. Higher muscle mass was associated with a lower risk of hyperglycemia and TC levels in individuals only with normal fat mass.
Transarterial chemoembolization combined with metformin improves the prognosis of hepatocellular carcinoma patients with type 2 diabetes
Authors: Chen Miao-Ling , Wu Chun-Xue , Zhang Jian-Bo , Zhang Hao , Sun Yuan-Dong , Tian Shi-Lin , Han Jian-Jun 
Published: September 2022

ObjectiveThe study aims to investigate the effect of metformin on Hepatocellular carcinoma (HCC) patients with type 2 diabetes mellitus (T2DM) who received transarterial chemoembolization (TACE) for the first time.MethodsFrom January 2016 to December 2019, T2DM patients diagnosed with HCC in Shandong Cancer Hospital and treated with TACE were included in this retrospective study. Overall survival (OS) and Progression-free survival (PFS) were compared between patients treated with metformin and other antidiabetics. Univariate and multivariate Cox regression models were used to evaluate the independent risk factors associated with OS and PFS. And sub-analysis was performed to investigate whether metformin could give a survival advantage in each Barcelona Clinic Liver Cancer (BCLC) stage of HCC. Propensity score matched (PSM) analyses based on patient and tumor characteristics were also conducted.ResultsA total of 123 HCC patients with T2DM underwent TACE, of which 50 (40.65%) received treatment with metformin. For the whole cohort, the median OS (42 vs 32 months, p=0.054) and PFS (12 vs 7 months, P=0.0016) were longer in the metformin group than that in the non-metformin group. Multi-analysis revealed that BCLC stage, BMI (Body Mass Index), and metformin use were independent predictors of OS. Metformin use was independently associated with recurrence. After PSM, 39 matched pairs were identified. The use of metformin was associated with a numerically longer m OS (43 vs 35 months, P=0.183) than the use of other anti-diabetics. And the difference in median PFS (13 vs 7 months, p=0.018) between the metformin group and non-metformin group remained significant.ConclusionThe combination of transarterial chemoembolization and metformin may be associated with better OS and PFS in HCC patients with T2DM.
A single-center analysis of genotype–phenotype characteristics of Chinese patients with autosomal dominant polycystic kidney disease by targeted exome sequencing
Authors: Yan Ziyan , Wang Yuchen , Deng Wenfeng , Zhou Yi , Hu Yangcheng , Qi Ka , Liu Ding , Xia Renfei , Liu Rumin , Zeng Wenli , Zhang Wei , Xu Jian , Xiong Fu , Miao Yun 
Published: September 2022

Background: Autosomal dominant polycystic kidney disease (ADPKD) is mainly caused by PKD1 and PKD2 mutations. However, only a few studies have investigated the genotype and phenotype characteristics of Asian patients with ADPKD. This study aimed to investigate the relationship between the natural course of ADPKD genotype and phenotype.Methods: Genetic studies of PKD1/2 genes of Chinese patients with ADPKD in a single center were performed using targeted exome sequencing and next-generation sequencing on peripheral blood DNA.Results: Among the 140 patients analyzed, 80.00% (n = 112) harbored PKD1 mutations, 11.43% (n = 16) harbored PKD2 mutations, and 8.57% (n = 12) harbored neither PKD1 nor PKD2 mutations. The average age at dialysis was 52.60 ± 11.36, 60.67 ± 5.64, and 52.11 ± 14.63 years, respectively. The renal survival rate of ADPKD patients with PKD1 mutations (77/112) was significantly lower than that of those with PKD2 mutations (9/16), leading to an earlier onset of end-stage renal disease (ESRD). Renal prognosis was poor for those with nonsense mutations, and they required earlier renal replacement therapy.Conclusions: The genotype and phenotype characteristics of ADPKD patients potentially vary across ethnic groups. Our findings supplement the genetic profiles of Chinese ADPKD patients, could serve as a guide for therapy monitoring and prognosis assessment of ADPKD, and may improve the clinical diagnosis.