bluuebunny/crossref_metadata_2025_split huggingface dataset:
A survey of cone beam computed tomography use amongst endodontic specialists in the United Kingdom
Authors: Patel Shanon , Brown Jackie , Foschi Federico , Al‐Nuaimi Nassr , Fitton James 
Published: February 2025

AbstractIntroductionThe aim of this study was to investigate the applications of cone beam computed tomography (CBCT) amongst endodontic specialists in the United Kingdom (UK) via an online survey.MethodsAn online invitation to take part in the survey was sent out to 306 specialist endodontists registered on the UK specialist register. The survey consisted of a series of questions associated with demographics, access and use of CBCT, utilization of dose optimization parameters, and frequency of use in different clinical scenarios.ResultsIn total, 202 respondents completed the survey (a response rate of 66.3%), 128 were male (63.4%), and 74 were female (36.6%). Of the 202 respondents, 174 (85.7%) used CBCT for diagnosis and/or management of endodontic problems. A CBCT scanner was on‐site in 71.3% (n = 124) and 28.7% (n = 50) being off‐site. A small field of view (FOV) was the prescribed scan in most cases (88.5%, n = 154/174). The cost of the CBCT scan was included in the assessment/treatment fee in 21.8% (38/174) of cases, with 78.2% (136/174) charged a separate fee for the scan. In total, 89.1% (155/174) respondents used CBCT ‘often or always’ for management of complex root canal anatomy, 87.4% (152/174) for root resorption, 84.5% (147/174) for periapical microsurgery, only 20.7% (36/174) of respondents would use CBCT to assess the outcome of treatment. Only 35.1% (61/174) of respondents would prescribe a CBCT scan for a pregnant patient and 78.2% (136/174) would take a CBCT scan for a paediatric patient. In total, 22.4% (39/174) of respondents did not report or request reports of their CBCT scans. Respondents chose to alter the exposure parameters depending on the patient's age or if the dentition was deemed extensively restored. Of the clinicians who incorporate CBCT into their practice, 93.7% (164/174) believe it improves the quality of the care they provide, and 93.6% (163/174) felt that the use of CBCT improves confidence in their diagnosis.ConclusionsThe use of CBCT amongst specialist endodontists in the UK is commonplace. However, usage does not appear to completely follow best practice guidance for certain clinical scenarios and highlights the need for further training in CBCT.
The emotional politics of return migration: Negotiating im/mobilities across borders and generations
Authors: Sampaio Dora 
Published: February 2025

AbstractIn this article, I engage with the return migration and ageing nexus from an intergenerational vantage point. I build on the analytical power of emotions to argue for paying careful attention to the salient emotional dimensions of migration and what I term the emotional politics of return migration. I discuss the relationality, multiple temporalities and elusiveness of return by drawing on in‐depth interviews and ethnographic observations with transnational families: specifically, the adult offspring who have emigrated to the United States – where they experience legal uncertainty – and their ageing parents in Brazil. The article contributes to scholarship on return migration and ageing in two ways. First, by emphasizing a temporal dimension where the emotional politics of return migration take shape through uneven rhythms, frequencies and intensities of contact, and second, by underscoring an intersubjective, familial component, where the return is mediated through bodily interaction, digital technologies and discourses of emotivity.
Validity and Reliability of the Self‐Care of Chronic Illness Inventory and Self‐Care Self‐Efficacy Scale in Patients Living With Cancer
Authors: Di Nitto Marco , Durante Angela , Torino Francesco , Bolgeo Tatiana , Damico Vincenzo , Ghizzardi Greta , Zerulo Sipontina Rita , Alvaro Rosaria , Vellone Ercole , Biagioli Valentina 
Published: February 2025

ABSTRACTAimThis study aimed to test the psychometric properties of the Self‐Care of Chronic Illness Inventory and the Self‐Care Self‐Efficacy scale in patients with cancer.DesignA multisite cross‐sectional validation study was conducted.MethodsBetween November 2022 and July 2023, a convenience sample of 318 patients with cancer were enrolled in five Italian inpatient and outpatient facilities. Confirmatory factor analysis was performed on the three scales of the Self‐Care of Chronic Illness Inventory and the Self‐Care Self‐Efficacy scale. Internal consistency was tested using Cronbach's alpha for unidimensional scales and McDonald's Omega for multidimensional scales. Construct validity was assessed with the global health status by Pearson's correlation. The COnsensus‐based Standards for the selection of health Measurement INstruments reporting guidelines were followed for the reporting process.ResultsThree hundred fourteen patients were included (median age: 55.5 years; male: 53.82%). Confirmatory factor analysis showed supportive fit indices for the three Self‐Care of Chronic Illness Inventory scales (CFI: 0.977–1.000; SRMR: 0.004–0.78) and the Self‐Care Self‐Efficacy scale (CFI: 1.000; SRMR: 0.014). All scales demonstrated adequate internal consistency (0.89–0.99) and test–retest reliability (0.85–0.95). Construct validity was confirmed through correlations between Self‐Care Self‐Efficacy, each Self‐Care of Chronic Illness Inventory scale, and global health status.ConclusionThe Self‐Care of Chronic Illness Inventory and Self‐Care Self‐Efficacy scales demonstrated excellent psychometric qualities and construct validity when administered to patients with cancer. Future research should explore self‐care behaviours across different diseases and cultural contexts.Implications For the ProfessionThese tools can help develop targeted educational programs, improving patient outcomes.ImpactCurrently, there is a lack of knowledge regarding self‐care behaviours in patients with cancer. These tools enable healthcare professionals to identify patient needs, design personalised interventions, and monitor their effectiveness over time.Patient or Public ContributionNo patient or public contribution.
Supporting Parents of Adolescents With Intellectual Disabilities: A Systematic Review of Interventions
Authors: Scripps Emma , Sutherland Daniel , Langdon Peter E. , Hastings Richard P. , Gray Kylie M. 
Published: February 2025

ABSTRACTBackgroundThis review aimed to synthesise the literature about interventions for parents of adolescents with intellectual disability, including parental experience of receiving interventions and intervention effectiveness.MethodsEligible interventions aimed to improve parenting skills and/or parent–adolescent relationships, adolescent behavioural/emotional problems and/or parent well‐being. ASSIA, EMBASE, Medline, PsycINFO and Web of Science were last searched on 11 July 2024. The TIDieR checklist and the MMAT were used for quality appraisal. A narrative synthesis was conducted. (Pre‐registration: PROSPERO CRD42022384409).ResultsTwelve studies with 1041 families were included. Intervention descriptions were detailed; however, study quality was mixed. Nearly all studies reported the intervention was associated with positive effects on parenting, parent–adolescent relationships, adolescent behaviour/emotional problems or parent well‐being. Three randomised controlled trials (RCTs) offer the strongest evidence but are limited in quality. All studies investigating parent experiences reported positive responses.ConclusionsHigh‐quality studies (e.g., RCTs) are needed to enable conclusions about efficacy and effectiveness.
Geomorphological River Characteristics Explain Species Turnover in Amphibians, Reptiles and Lemurs in Madagascar's Eastern Rainforests
Authors: Schüßler Dominik , Bremer Jonas , Sauerwein Martin , Radespiel Ute 
Published: February 2025

ABSTRACTAimThe riverine barrier hypothesis is often tested as a driver for allopatric speciation. Rivers are usually treated as static landscape features characterised by their width and elevation of their headwaters. We aim to investigate the role of rivers as barriers using a comprehensive database of geomorphological characteristics by assessing their influence on species turnover rates.LocationEastern Madagascar.TaxonSixty‐two taxa from 11 genera of lemurs, amphibians and reptiles.MethodsWe compiled 21 geomorphological variables for 45 major rivers, estimated species turnover rates from species assemblages on either side and modelled the influence of river characteristics on species diversity. Topographic depressions, identified from longitudinal river profiles, and landscape heterogeneity were further analysed as potential palaeoclimatic refugia and alternative speciation drivers.ResultsA total of 24 rivers acted as species barriers. Three of these had disproportionately high species turnover rates and shared a set of distinct geomorphological features like the maximum elevation of the watershed, high flow accumulation values at the outlet and at an elevation of 800 m and a high concavity of the longitudinal river profile. Other variables like landscape heterogeneity along the main river channel and length of the coastal plain further helped to differentiate between rivers with intermediate turnover rates. Species richness peaked in northeastern Madagascar, a region with the highest abundance of topographic depressions and inferred palaeo‐wetlands.Main ConclusionsGeomorphological river characteristics effectively explained variations in species turnover rates. However, it remains uncertain whether rivers functioned as secondary dispersal barriers and thereby maintainers of species diversity, rather than as primary drivers of allopatric speciation. Additionally, we emphasise the role of refugia during palaeoclimatic oscillations, which are often associated with topographic depressions. Overall, integrating rivers as dynamic fluvial systems through space and time into biogeographic studies offers valuable insights into speciation, dispersal and the persistence of taxa.
Understanding the swimming performance, behaviour and metabolism of the rare juvenile Kaluga sturgeon (Huso dauricus) for its conservation and management
Authors: Zhu Guanyu , Ma Bo 
Published: February 2025

AbstractThe Kaluga sturgeon, Huso dauricus, is a rare fish species found in the Heilongjiang River basin of China, primarily within the mainstream of the Heilongjiang River. However, recent years have witnessed the degradation of its wild population due to factors such as overfishing, water pollution and water conservancy construction. To safeguard the genetic diversity of H. dauricus, it is essential to investigate its swimming capabilities, behaviour and metabolic rate during physical activity. This research yields fundamental insights and technical support for fishery enhancement, release strategies, artificial breeding and fishway design. In this study, we assessed critical swimming speed, burst swimming speed and oxygen consumption of H. dauricus. High‐speed cameras recorded H. dauricus' swimming behaviour at various speeds, enabling a detailed analysis of tail beat frequency, tail beat amplitude and motion step length (LS). This study contributes crucial baseline data for not only understanding fish behaviour in the Heilongjiang basin but also being a vital technical support for fish stocking initiatives and the design of fish passage facilities in water conservancy projects. These findings hold significant implications for protecting and restoring H. dauricus germplasm resources in the region.
Lymphocystis Disease Virus Infection in Cultured Three‐Spot Gourami (Trichogaster trichopterus) in Brazil
Authors: Marcelino Sóstenes A. C. , Gorza Leonardo L. , Carneiro Sarah P. , Oliveira Ellen C. , Nogueira Luiz F. F. , Figueiredo Henrique C. P. , Ramirez Matheus A. , Armien Anibal G. , Tavares Guilherme C. , Pierezan Felipe 
Published: February 2025

ABSTRACTLymphocystis disease virus (LCDV) infection induces massive hypertrophy of dermal cells with intracellular accumulation of virions, resulting in skin nodules that are observed to the naked eye. In September 2022, an ornamental fish producer noted white spots and nodules on the skin and fins of a three‐spot gourami (Trichogaster trichopterus) population, which compromised the aesthetic of the fish. The disease only affected this fish species in the farm and was intermittent. Ten diseased and four apparently healthy fish were collected during the first sampling, and 20 diseased fish were collected approximately 1 year after for a follow‐up examination. Macroscopically, the fish presented isolated or small clusters of white to grey nodules, measuring 0.1–0.5 mm, concentrated on the fins and caudal peduncle. Histologically, nodules in the skin and internal viscera were composed of numerous hypertrophied cells with nucleolar components and karyomegaly and thick hyaline cell walls. Virions, with a diameter of approximately 180 nm, were visualised in infected interstitial cells in the skin through transmission electron microscopy. The presence of LCDV in the skin, spleen, and kidney was confirmed by specific PCR. Phylogenetic analysis of the MCP gene revealed that the isolates from Brazilian gouramis belonged to the cluster of LCDV genogroup VI, similar to an unclassified virus identified in a population of gouramis in Korea. This report describes the pathological and molecular findings of LCDV infection in cultured three‐spot gourami in Brazil.
The Deubiquitinase USP2 Modulates Photic Entrainment of the Circadian Clock at the Level of the Suprachiasmatic Nucleus
Authors: Srikanta Shashank B. , Brown Thomas W. , Malescot Antoine , Cloutier Marie‐Ève , Zhu Lei , Coutanson Christine , Malki Maryam , Storch Kai‐Florian , Rungta Ravi , Cayouette Michel , Dkhissi‐Benyahya Ouria , Cermakian Nicolas 
Published: February 2025

ABSTRACTUbiquitin‐specific peptidase 2 (USP2) is a deubiquitinase (DUB) with a diversity of functions in physiology. One of these functions is the regulation of circadian rhythms, which are physiological rhythms with a period of ~24 h. Previous studies have indicated a role for USP2 in photic entrainment, the process by which circadian clocks synchronize to environmental light cues. Here, we investigated the implication of USP2 in this process, using Usp2 knockout (KO) mice. Using different light treatments and running wheel recordings, we established that USP2 controls entrainment of the clock to light cues at dusk. Further, we showed that Usp2 is expressed throughout the suprachiasmatic nucleus (SCN), the site of the central clock, and in the retina. This raised the question of where USP2 acts on circadian photoreception. We found that it is not within the retina, as retinas of Usp2 KO mice have an intact structure and unaltered photoreception through intrinsically photosensitive retinal ganglion cells. Moreover, KO of Usp2 within the retina does not alter clock entrainment to light. In contract, KO of Usp2 in the SCN causes a light entrainment phenotype similar to full‐body KO mice, showing that the action of USP2 in modulating photic entrainment predominantly takes place in the SCN. Finally, within the SCN, we found that induction of clock gene Per1 and activation of MAPK/ERK pathway in response to light were blunted in Usp2 KO mice. Altogether, we established a key role for USP2 in regulating photic entrainment by modulating light‐responsive pathways within the SCN.image
Unique Nerve Tissue‐Restricted T‐Cell Clones in Chronic Inflammatory Demyelinating Polyneuropathy
Authors: van Lieverloo G. G. A. , Anang D. C. , Adrichem M. E. , Coert B. A. , Aronica A. E. , Wieske L. , van Schaik I. N. , de Vries N. , Eftimov F. 
Published: February 2025

ABSTRACTBackground and AimsChronic inflammatory demyelinating polyneuropathy (CIDP) is an immune‐mediated disorder characterized by peripheral nerve damage. Although T lymphocytes (T‐cells) are implicated in the pathogenesis of CIDP, we previously observed that the frequency of highly expanded T‐cell clones (HECs) in peripheral blood of CIDP patients was not different from healthy controls. To investigate if local T‐cells might be pathogenic, we employed next‐generation sequencing to compare the TCRβ repertoire between peripheral blood and nerve tissue of CIDP patients.MethodsAdaptive immune receptor repertoire sequencing (AIRR‐Seq) of the TCRβ chain was conducted on peripheral blood and nerve tissue obtained from three newly diagnosed CIDP patients.ResultsAll patients showed high numbers of highly expanded TCRβ clones in nerve tissue that were not detected or detected only in very low frequencies in blood, whereas in blood other HECs were found. Clustering analysis based on CDR3‐similarity showed that these nerve tissue‐restricted TCRβ clones were distinct from blood clones, as evidenced by the absence of prominent clusters.InterpretationUnique nerve tissue‐restricted TCRβ clones may indicate a highly localized immune response with localized expansion and/or retention of T‐cells that could contribute to the pathomechanism of CIDP.Further characterization of the phenotype, antigen target and functionality of these T‐cells is essential to determine their pathogenic role.
The Efficacy of 308‐nm Excimer Laser With TopicalBimatoprost 0.03% for Facial Vitiligo
Authors: Ghiasi Maryam , Isazade Ahdie , Marhamati Tahereh , Lajevardi Vahideh , Shakoei Safoura 
Published: February 2025

ABSTRACTBackgroundVitiligo is a commonly acquired autoimmune pigmentary disorder. Some patients resist conventional treatments, leading to the search for combination therapies.AimsThis study aimed to compare the efficacy of 308‐nm excimer laser monotherapy versus combined treatment with topical bimatoprost 0.03% in patients with facial vitiligo.Patients and MethodsA single‐blind randomized clinical trial was conducted at Razi Hospital, Tehran, on 38 patients with facial vitiligo who had at least one facial vitiligo patch and had not undergone treatment in the past 3 months. The patients were randomly allocated to either the intervention group (n = 18) or the control group (n = 20). Both groups received 308‐nm EL therapy twice weekly for 15 weeks, while the intervention group additionally applied 0.03% bimatoprost solution daily. The patients were visited at the end of every 5 weeks and after the 15th week. Efficacy was evaluated using the scale for improvement assessment (SAI), visual analog scale satisfaction (VASS), and visual analog scale improvement (VASI). Data analysis was performed using the Mann–Whitney and t‐tests, with a significance level set at p < 0.05.ResultsOf the total patients, 27 (71.05%) were female and 11 (28.95%) were male. The male‐to‐female ratio was 50% in the intervention group and 33.33% in the control group. The mean VASI score, as the primary outcome, showed a significant increase over time in the intervention group (p ≤ 0.001), increasing from 4.53 to 7.20 (an increase of 2.67 units). Additionally, the intervention had a significant effect on the VASI outcome compared to the control (p ≤ 0.001; mean difference: 2.55 [1.63 to 3.47]). As the secondary outcomes, the mean VASS and SAI scores significantly decreased over time in the intervention group (p ≤ 0.05). The intervention also significantly affected the VASS and SAI outcomes compared to the control (p ≤ 0.001). The side effects of the intervention group were hypertrichosis in three patients and erythema burning in one patient.ConclusionsAdding bimatoprost 0.03% to the treatment regimen may improve the outcomes of patients with facial vitiligo who are resistant to conventional treatments.
Do You Drink Coffee, or Brand? Brand Effect on Consumers' Liking and Emotional Responses to Instant Coffee Among Korean Consumers
Authors: Park Seyeong , Hwang In‐Seo , Yoon Gyeonghye , Lim Manyoel , Park Min Kyung , Oh Jungmin , Kwak Han Sub 
Published: February 2025

ABSTRACTThe impact of correct and incorrect brand information on consumer preferences and emotional responses to premium and budget instant coffee products was investigated. Acceptance ratings, just‐about‐right scale for sensory attributes, and emotion response profiles were used to explore product quality and brand information influence on sensory evaluations. A significantly stronger brand effect was noted for premium products, compared with that of intrinsic attributes on consumer preference and emotions. Premium product showed high acceptance ratings and positive emotional responses when brand information was correct. Budget products showed a strong reliance on intrinsic qualities. The penalty analysis indicated that the products had different attributes requiring improvement based on brand information, highlighting the association between premium brand expectations and product quality. Leveraging brand information for premium brands is important to enhance consumer satisfaction and emotional engagement. Economic brands should focus on improving their intrinsic qualities.
S‐Allyl‐Cysteine Ameliorates Cirrhotic Portal Hypertension by Enhancing Lymphangiogenesis via a VEGF‐C‐Independent Manner
Authors: Luo Guqing , Wu Zhenghao , Fan Qiang , Zhang Chihao , Lin Jiayun , Li Hongjie , Zhao Jinbo , Huo Haizhong , Qi Xiaoliang , Wu Guangbo , Chen Min , Yu Jiwei , Zheng Lei , Luo Meng 
Published: February 2025

ABSTRACTBackground and AimsLymphangiogenesis is enhanced during the development of liver cirrhosis and portal hypertension (PHT). However, hepatic lymphatic vascular system is understudied in liver cirrhosis and PHT. Hydrogen sulfide (H2S) and related compounds have potential prolymphangiogenic effects besides its previously reported vascular‐protective effects. Therefore, we aimed to investigate the effects of endogenous H2S donor S‐allyl‐cysteine (SAC) on bile duct ligation (BDL)‐induced liver cirrhosis and PHT.MethodsBDL rats with cholestatic liver cirrhosis and PHT were orally administrated with SAC at 100 or 200 mg/kg/day, as well as DL‐propargylglycine (PAG) or MAZ‐51 injections. Hemodynamic parameters were determined, and subsequent evaluations of liver fibrosis, intrahepatic vascular resistance (IHVR) and lymphangiogensis were performed. Human lymphatic endothelial cells (hLECs) were used for in vitro verification of prolymphangiogenic effects of SAC.ResultsSAC treatment significantly decreased PP and promoted endogenous H2S production. Liver fibrosis and IHVR were also ameliorated. Hepatic and mesenteric lymphangiogenesis were enhanced in BDL rats and further promoted by SAC despite a significant downregulation of hepatic VEGF‐C. Inhibition of H2S production by PAG significantly reduced lymphatic vessels, while inhibition of lymphangiogensis by MAZ‐51 reversed the protective effects of SAC against PHT. SAC enhanced lymphangiogenic functions in vitro by promoting cellular H2S production and activating Akt phosphorylation without altering VEGF‐C/D, which were reversed by PAG and MAZ‐51.ConclusionsSAC significantly alleviated BDL‐induced liver cirrhosis and PHT. Meanwhile, elevated H2S induced by SAC facilitated lymphangiogenesis via a VEGF‐C‐independent manner, which contributed to the alleviation of PHT.