bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypofractionated radiation leads to more rapid bleeding cessation in women with vaginal bleeding secondary to gynecologic malignancy
Authors: Moradi Luke A. , Schneider Craig S. , Deshane Alok S. , Popple Richard A. , Kim Robert Y. , Marcrom Samuel R. 
Published: February 2022

Abstract
Background
Vaginal bleeding (VB) is common in women with gynecologic (GYN) malignancies. Radiation therapy (RT) is used for the definitive treatment of GYN cancers and palliation of bleeding. The historical dogma is that high dose-per-fraction radiation leads to more rapid bleeding cessation, yet there is scant data supporting this claim. We sought to examine the effect of RT fraction size on VB via retrospective analysis of patients receiving hypofractionated radiation (HFRT) compared to conventionally fractionated radiation (CFRT) for control of bleeding secondary to GYN malignancies.

Methods
We identified patients receiving external beam RT for continuous VB from GYN malignancy treated in our department from 2012 to 2020. RT was classified as HFRT (> 2.0 Gy/fx) or CFRT (1.8–2.0 Gy/fx). Demographic information, disease characteristics, and treatment details were collected. The primary endpoint was days from RT initiation until bleeding resolution. Characteristics between groups were compared via Fisher’s exact test. Time to bleeding cessation was assessed via Kaplan–Meier and log-rank test. Univariable and multivariable Cox-proportional hazards were used to identify factors associated with bleeding cessation.

Results
We identified 43 patients meeting inclusion criteria with 26 and 17 patients receiving CFRT and HFRT, respectively. Comparison of baseline characteristics revealed patients receiving HFRT were older (p = 0.001), more likely to be post-menopausal (p = 0.002), and less likely to receive concurrent chemotherapy (p = 0.004). Time to bleeding cessation was significantly shorter for patients receiving HFRT (log-rank p < 0.001) with median time to bleeding cessation of 5 days (HFRT) versus 16 days (CFRT). Stratification by dose-per-fraction revealed a dose–response effect with more rapid bleeding cessation with increased dose-per-fraction. While HFRT, age, recurrent disease, prior pelvic RT, and prior systemic therapy were associated with time to bleeding cessation on univariable analysis, HFRT was the only factor significantly associated with time to bleeding cessation in the final multivariable model (HR 3.26, p = 0.008).

Conclusions
Patients with continuous VB from GYN tumors receiving HFRT experienced more rapid bleeding cessation than those receiving CFRT. For patients with severe VB, initiation of HFRT to control malignancy related bleeding quickly may be warranted.
ZNF384 rearrangement in acute lymphocytic leukemia with renal involvement as the first manifestation is associated with a poor prognosis: a case report
Authors: Ma Jinlong , Guan Jiaheng , Chen Baoan 
Published: February 2022

Abstract
Background
Novel fusion genes such as ZNF384, have been identified in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) in recent years. Patients harboring ZNF384 rearrangements have a distinctive immunophenotype with weak CD10 and aberrant CD13 and/or CD33 expression. Thus, ZNF384-rearranged ALL is a unique subtype of BCP-ALL. However, research on the prognostic significance of ZNF384 rearrangements has been limited to date, especially in adolescents.

Case presentation
We described a 17-year-old adolescent who was diagnosed with ALL and had renal involvement as the first manifestation, which was very rare in the existing studies. FISH analysis indicated a rearrangement of ZNF384 according to its probe. The patient had a typical characteristic immunophenotype of ZNF384 rearrangement, with CD10 negativity and CD13 and CD33 positivity. She had an unfavorable prognosis because she responded poorly to chemotherapy and developed a relapse shortly after reaching CR.

Conclusion
The importance of ZNF384 rearrangements in terms of prognosis remains unclear. We reported an adolescent who was diagnosed with ZNF384-rearranged ALL with renal involvement. She underwent different therapies, but her prognosis remained poor. Since ZNF384 rearrangements may act as a prognostic predictor in children or adolescents, early detection based on its characteristic immunophenotype is of great necessity.
The effects of learning with various noise on Gait Kinematics in 3-to-5-year-old children: a randomized controlled trial
Authors: Ghorbani Maryam , Yaali Rasoul , Schöllhorn Wolfgang I. , Letafatkar Amir , Sadeghi Hassan 
Published: February 2022

Abstract
Background
Lack of the neuromuscular control during locomotion in the knee joint leads to an increased risk of anterior cruciate ligament (ACL) injury in children. Hence, we aimed to explore the effects of a repetitive, model-oriented, and self-organized approach on lower limb kinematics during gait in children.

Methods
In randomized controlled trial, 36 children with 4 ± 0.79 years of age from the children gym were randomly (a lottery method) allocated into three groups, including (1) the model-oriented (n = 10), (2) Differential Learning (n = 11), and (3) control (n = 10) groups. Kinematic data of hip, knee, and ankle joints in the sagittal plane were recorded by a GoPro camera at the moments of heel-ground contact and toe-off the ground before and after a 6-week intervention (two sessions per week).

Results
The results indicate a 35% post-intervention increase of ankle dorsiflexion (95% CI: − 5.63 _ − 0.96) in the moment of heel-ground contact in the model-oriented group; however, knee flexion (95% CI: − 1.05 _ 8.34) and hip flexion (95% CI: 3.01 _ 11.78) were respectively decreased by 20% and 20%. After the intervention, moreover, ankle plantar flexion (95% CI: − 9.18 _ − 2.81) and hip extension (95% CI: − 12.87 _ − 3.72) have respectively increased by 37% and 37%, while knee flexion (95% CI: 3.49 _ 11.30) showed a %16 decrease in the moment of toe off the ground. As for the Differential Learning group, ankle dorsiflexion (95% CI: − 5.19 _ − 1.52) increased by 33%, and knee (95% CI: 0.60 _ 5.76) and hip flexion (95% CI: 2.15 _ 7.85) respectively decreased by 17% and 17% at the moment of the heel-ground contact following the intervention. At toe lifting off the ground, the plantar flexion (95% CI: − 7.77 _ − 2.77) increased by 35%, knee flexion (95% CI: 2.17 _ 7.27) decreased to 14%, and hip extension (95% CI: − 9.98 _ − 4.20) increased by %35 following the intervention for the Differential Learning group subjects. Based on the results obtained from the one-way ANOVA, there was a significant difference between these groups and the control group in all kinematic gait variables (p ≤ 0.05). However, no statistically significant differences were found between the two experimental groups.

Conclusions
The results implied that the model-oriented repetitive and the self-organized Differential Learning approach were both appropriate to alter the kinematic gait pattern in the 3–5-year-old children. Previous research has almost exclusively recommended a model-oriented approach to change kinematic patterns and preventing non-contact motor injuries. However, the present study showed that the Differential Learning approach can help children to achieve the same goal by continuously changing environments and stimulating challenges.
Trial registration: Current Controlled Trials using the IRCT website with ID number of, IRCT20130109012078N5 “Prospectively registered” at 14/5/2021.
Role of ammonia for brain abnormal protein glycosylation during the development of hepatitis B virus-related liver diseases
Authors: Yang Jiajun , Yin Mengqi , Hou Yao , Li Hao , Guo Yonghong , Yu Hanjie , Zhang Kun , Zhang Chen , Jia Liyuan , Zhang Fan , Li Xia , Bian Huijie , Li Zheng 
Published: February 2022

Abstract
Background
Ammonia is the most typical neurotoxin in hepatic encephalopathy (HE), but the underlying pathophysiology between ammonia and aberrant glycosylation in HE remains unknown.

Results
Here, we used HBV transgenic mice and astrocytes to present a systems-based study of glycosylation changes and corresponding enzymes associated with the key factors of ammonia in HE. We surveyed protein glycosylation changes associated with the brain of HBV transgenic mice by lectin microarrays. Upregulation of Galβ1-3GalNAc mediated by core 1 β1,3-galactosyltransferase (C1GALT1) was identified as a result of ammonia stimulation. Using in vitro assays, we validated that upregulation of C1GALT1 is a driver of deregulates calcium (Ca2+) homeostasis by overexpression of inositol 1,4,5-trisphosphate receptor type 1 (IP3R1) in astrocytes.

Conclusions
We demonstrated that silencing C1GALT1 could depress the IP3R1 expression, an effective strategy to inhibit the ammonia-induced upregulation of Ca2+ activity, thereby C1GALT1 and IP3R1 may serve as therapeutic targets in hyperammonemia of HE.
Identity-based remote data checking with a designated verifier
Authors: Ji Yanyan , Shao Bilin , Chang Jinyong , Xu Maozhi , Xue Rui 
Published: February 2022

AbstractTraditional remote data possession auditing mechanisms are usually divided into two types: private auditing and public auditing. Informally, private auditing only allows the original data owner to check the integrity of its outsourced data, whereas anyone is allowed to perform the checking task in public auditing. However, in many practical applications, the data owner expects some designated verifier (instead of others) to audit its data file, which cannot be covered by the existing private or public auditing protocols. Thus, in a recent work, Yan et al. proposed a new auditing technique with a designated verifier [IEEE Systems Journal, 12(4): 1788-1797, 2020]. Nevertheless, we note that this protocol suffers from complicated management of certificates and hence heavily relies on public key infrastructure. To overcome this shortcoming, in this paper, we propose an identity-based auditing protocol with a designated verifier, which not only avoids the introduction of certificates, but also has the desired property of only allowing specific verifier to audit. Its security is based on the classical computational Diffie-Hellman and Weil Diffie-Hellman assumptions. Finally, performance analysis shows that our proposed protocol is very efficient and suitable for some real-life applications.
Regional health care profiles – an improved method for generating case studies on the catchment areas of envisaged primary health care units in Austria: a report to the InfAct Joint Action
Authors: Mathis-Edenhofer Stefan , Röthlin Florian , Wachabauer David , Haneef Romana , Ventura Ilana , Fülöp Gerhard 
Published: February 2022

Abstract
Background
The recent Austrian Primary Care Act established new primary health care units (PHCUs) and obliged them to draw up a “care strategy” specifying their focal care tasks and objectives and emphasizing the health care needs of the population in their catchment area with its specific local health and epidemiological profile. The main purpose of these care strategies is thus to ensure that care-providers meet the local needs, but they also provide a rationale for evaluation and organizational development. To assist new PHCUs in establishing care strategies it was necessary to develop a method for automatically generating comprehensive local case studies for any freely definable location in Austria.

Results
We designed an interactive report generator capable of producing location-specific regional health care profiles for a PHCU located in any of Austria’s 2122 municipalities and of calculating the radius of its catchment area (defined by different levels of maximum car-travelling times). The reports so generated, called “regional health care profiles for primary health care” (RHCPs/PHC), are in comprehensive PDF report format. The core of each report is a set of 35 indicators, classified under five health and health service domains. The reports include an introductory text, definitions, a map, a graphic and tabular presentation of all indicator values, including information on local, supra-regional and national value distribution, a ranking, and numbers of service providers (e.g. pharmacies, surgeries, nursing homes) located within the catchment area.

Conclusions
The RHCPs/PHC support primary health care planning, efforts to improve care-effectiveness, and strategic organizational development by providing comprehensive information on the health of the population, the utilization of health services and the health care structures within the catchment area. In addition to revealing the scope and nature of the health care needed, they also provide information on what public health approaches are necessary. RHCPs/PHC for different locations have already been distributed to numerous stakeholders and primary health care providers in Austria.
Small hydropower plants in Western Balkan countries: status, controversies and a proposed model for decision making
Authors: Pavlakovič Barbara , Okanovic Andrea , Vasić Bojana , Jesic Jelena , Šprajc Polona 
Published: February 2022

Abstract
Background
As the countries of the Western Balkans (WB) have committed to sustainable development, the process of regulatory and economic adjustment is underway. As part of the aforementioned fact, the WB countries have commenced exploitation of energy from renewable sources, among which hydropower is the most important. The main objective of the study is to analyse the status of renewable energy transition in the WB region, focusing on the construction and exploitation of small hydropower plants (SHPPs), as well as a proposal for an original model for decision making in this field, based on a multidimensional decision-making space. Namely, in most cases, there is resistance to the construction of SHPPs in the WB territory, as well as divided opinion among investors, companies, environmental movements, academia, and citizens on this issue. This shows that the entire decision-making process has to be reviewed and re-designed.

Results
The results of the study show that the construction of SHPPs caused damage to environmentally protected areas, living conditions of local communities, touristic and agricultural potential. All of the foregoing matters have led to mass protests by citizens and a high degree of mistrust so that the future of SHPPs in the WB is extremely uncertain. The assessment of the acceptability of existing SHPPs through the proposed model showed that 74% of SHPPs cannot be considered acceptable from the aspect of the location where they were built, and from the aspect of the impact on the quality of life of the local population. Accordingly, this paper provides suggestions for much-needed improvements.

Conclusions
The construction of SHPPs is causing numerous controversies, opposition, and resistance. To find the right solution, and contribute to sustainable energy and economic development, it is necessary to develop a fully transparent and objective policy system in this field, and to use contemporary models for decision making with emphasis on the involvement local communities in the decision-making process.
How public health crises expose systemic, day-to-day health inequalities in low- and-middle income countries: an example from East Africa
Authors: Davis Alicia , Lembo Tiziana , Laurie Emma , Mutua Edna , Loosli Kathrin , Nthambi Mary , Nimegeer Amy , Mnzava Kunda , Msoka Elizabeth F. , Nasuwa Fortunata , Melubo Matayo , Shirima Gabriel , Matthews Louise , Hilton Shona , Mshana Stephen E. , Mmbaga Blandina T. 
Published: February 2022

AbstractBackgroundThe current Coronavirus disease pandemic reveals political and structural inequities of the world’s poorest people who have little or no access to health care and yet the largest burdens of poor health. This is in parallel to a more persistent but silent global health crisis, antimicrobial resistance (AMR). We explore the fundamental challenges of health care in humans and animals in relation to AMR in Tanzania.MethodsWe conducted 57 individual interviews and focus groups with providers and patients in high, middle and lower tier health care facilities and communities across three regions of Tanzania between April 2019 and February 2020. We covered topics from health infrastructure and prescribing practices to health communication and patient experiences.ResultsThree interconnected themes emerged about systemic issues impacting health. First, there are challenges around infrastructure and availability of vital resources such as healthcare staff and supplies. Second, health outcomes are predicated on patient and provider access to services as well as social determinants of health. Third, health communication is critical in defining trusted sources of information, and narratives of blame emerge around health outcomes with the onus of responsibility for action falling on individuals.ConclusionEntanglements between infrastructure, access and communication exist while constraints in the health system lead to poor health outcomes even in ‘normal’ circumstances. These are likely to be relevant across the globe and highly topical for addressing pressing global health challenges. Redressing structural health inequities can better equip countries and their citizens to not only face pandemics but also day-to-day health challenges.
The effectiveness of the early orthodontic correction of functional unilateral posterior crossbite in the mixed dentition period: a systematic review and meta-analysis
Authors: Alsawaf Danya Hassan , Almaasarani Salam Ghazwan , Hajeer Mohammad Y. , Rajeh Nada 
Published: February 2022

Abstract
Objective
This systematic review and meta-analysis aimed to critically appraise the available evidence of the effectiveness of early intervention of functional unilateral posterior crossbites (FPXB) between the ages of 6 and 12 years.

Materials and methods
Electronic search in four databases (PubMed, Scopus, Embase, and Google Scholar) for randomized controlled trials (RCTs) and controlled clinical trials (CCTs) was performed between 1st January 1990 and 31st October 2021. Methodological index for non-randomized studies (MINORS) for CCTs and Cochrane's risk of bias tool for RCTs were applied. The certainty of the evidence was evaluated according to the grading of recommendations, assessment, development, and evaluation (GRADE) approach.

Results
Nine studies (6 RCTs and 3 CCTs) were included in this review, and six of them were appropriate for quantitative synthesis. The meta-analysis revealed that the quad-helix (QH) was more effective than expansion plates (EP) in increasing the intermolar width (WMD = 1.25; 95% CI 0.75, 1.75; P < 0.001), and decreasing treatment time (WMD = − 3.36; 95% CI − 4.97, − 1.75; P < 0.001). The relapse rate at 5.6 years post-treatment was greater in the QH group than in the EP group (RR = 3.00); however, the difference was statistically insignificant. There was no significant difference between the QH and the EP in other outcome measures. When assessing the rapid maxillary expansion (RME), only one RCT compared the RME with an untreated control group and reported a significant increase in the maxillary intermolar and intercanine width (P < 0.001, P = 0.002, respectively) and a significant decrease in lower midline deviation (P < 0.001).

Conclusion
There is weak to moderate evidence that the treatment of functional posterior crossbite (FPXB) by the QH increased the maxillary intermolar width and the success rate and decreased the treatment duration compared to the EP. The relapse percentage was greater in the QH group. There is very weak evidence that the mandibular midline correction rate did not differ significantly between the QH and the EP modalities. The RME using the Hyrax appliance corrected the FPXB successfully; however, the strength of evidence in this regard is very low. As the quality of evidence ranged from very low to moderate in this review, we confirm the need for more RCTs with different expansion appliances in the early treatment of FPXB.
Social network data analysis to highlight privacy threats in sharing data
Authors: Cerruto Francesca , Cirillo Stefano , Desiato Domenico , Gambardella Simone Michele , Polese Giuseppe 
Published: February 2022

AbstractSocial networks are a vast source of information, and they have been increasing impact on people’s daily lives. They permit us to share emotions, passions, and interactions with other people around the world. While enabling people to exhibit their lives, social networks guarantee their privacy. The definitions of privacy requirements and default policies for safeguarding people’s data are the most difficult challenges that social networks have to deal with. In this work, we have collected data concerning people who have different social network profiles, aiming to analyse privacy requirements offered by social networks. In particular, we have built a tool exploiting image-recognition techniques to recognise a user from his/her picture, aiming to collect his/her personal data accessible through social networks where s/he has a profile. We have composed a dataset of 5000 users by combining data available from several social networks; we compared social network data mandatory in the registration phases, publicly accessible and those retrieved by our analysis. We aim to analyse the amount of extrapolated data for evaluating privacy threats when users share information on different social networks to help them be aware of these aspects. This work shows how users data on social networks can be retrieved easily by representing a clear privacy violation. Our research aims to improve the user’s awareness concerning the spreading and managing of social networks data. To this end, we highlighted all the statistical evaluations made over the gathered data for putting in evidence the privacy issues.
Image captioning model using attention and object features to mimic human image understanding
Authors: Al-Malla Muhammad Abdelhadie , Jafar Assef , Ghneim Nada 
Published: February 2022

AbstractImage captioning spans the fields of computer vision and natural language processing. The image captioning task generalizes object detection where the descriptions are a single word. Recently, most research on image captioning has focused on deep learning techniques, especially Encoder-Decoder models with Convolutional Neural Network (CNN) feature extraction. However, few works have tried using object detection features to increase the quality of the generated captions. This paper presents an attention-based, Encoder-Decoder deep architecture that makes use of convolutional features extracted from a CNN model pre-trained on ImageNet (Xception), together with object features extracted from the YOLOv4 model, pre-trained on MS COCO. This paper also introduces a new positional encoding scheme for object features, the “importance factor”. Our model was tested on the MS COCO and Flickr30k datasets, and the performance is compared to performance in similar works. Our new feature extraction scheme raises the CIDEr score by 15.04%. The code is available at: https://github.com/abdelhadie-almalla/image_captioning