bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multifunctional DNA Hydrogel Enhances Stemness of Adipose‐Derived Stem Cells to Activate Immune Pathways for Guidance Burn Wound Regeneration
Authors: Zhou Liping , Zeng Zehua , Liu Songyang , Min Tiantian , Zhang Wenmin , Bian Xiaochun , Du Hongwu , Zhang Peixun , Wen Yongqiang 
Published: September 2022

AbstractA grade 3 burn is a nonstatic fatal injury, which can lead to complete damage to the skin structure, accompanied by a series of symptoms such as persistent inflammation, pain, pruritus, ulcer, and peripheral neuropathy. Although the primary clinical burn treatment is skin grafting, it cannot comprehensively solve burn symptoms. Here, a multifunctional DNA hydrogel integrated system is conveniently obtained through dynamic cross‐linking of the DNA unit, polyacrylamide, and l‐ascorbate 2‐phosphate (l‐A2P) formation of dense hydrogen bonds. The DNA hydrogel is doped with borneol for pain and itch relief. The obtained DNA hydrogel provides a hotbed similar to the extracellular matrix structure in vivo for the growth and development of stem cells, which can regulate cell proliferation, maintain cell viability, and achieve perfect release in a suitable environment. Additionally, the pharmacological wound dressing shell features excellent mechanical behavior, tissue adhesion, and antibacterial properties. Beyond that, the multifunctional DNA hydrogel integrated system can promote macrophage transformation, angiogenesis, and neurogenesis. Notably, the system activates the phosphatidylinositol 3′‐kinase (PI3K)‐Akt signaling pathway, which helps to promote tissue regeneration. Therefore, the DNA hydrogel integrated system opens the cascade mode of effective integrated treatment of burn wounds, further driving the in‐depth study of clinical transformation mechanisms in the future.
Surface Structure Evolution and its Impact on the Electrochemical Performances of Aqueous‐Processed High‐Voltage Spinel LiNi0.5Mn1.5O4 Cathodes in Lithium‐Ion Batteries
Authors: He Jiarong , Melinte Georgian , Darma Mariyam Susana Dewi , Hua Weibo , Das Chittaranjan , Schökel Alexander , Etter Martin , Hansen Anna‐Lena , Mereacre Liuda , Geckle Udo , Bergfeldt Thomas , Sun Zhipeng , Knapp Michael , Ehrenberg Helmut , Maibach Julia 
Published: September 2022

AbstractLiNi0.5Mn1.5O4 (LNMO) is a promising cathode in lithium‐ion batteries (LIBs) due to its high operating voltage and open Li+ diffusion framework. However, the instability of the electrode–electrolyte interface and the negative environmental impact of electrode fabrication processes limit its practical application. Therefore, switching electrode processing conditions to aqueous and understanding the accompanying surface structural evolution are imperative. Here, water‐treated, poly(acrylic acid) (PAA)‐treated, and H3PO4‐treated LNMO, labeled as W‐LNMO, A‐LNMO, and H‐LNMO, are studied systematically. W‐LNMO shows a high concentration of Mn3+ induced by Li loss while a conformal PAA layer formed on A‐LNMO reduces this phenomenon. H‐LNMO displays a second MnPO4∙H2O phase. Upon cycling, a fast capacity decay is observed in W‐LNMO while an extra plateau at ≈2.7 V appears in the initial charging, corresponding to a two‐phase transition. A surface reconstruction layer from a spinel to a rock‐salt phase with a reductive Mn2+ segregation is observed in W‐LNMO after 105 cycles. The PAA layer persists on A‐LNMO and alleviates the capacity decay. H‐LNMO delivers a relatively low capacity due to the formation of a MnPO4∙H2O phase. This study provides new insights into manipulating the surface chemistry of LNMO cathodes to enable aqueous, large‐scale processingin LIBs.
Liquid Confine‐Induced Gradient‐Janus Wires for Droplet Self‐Propelling Performances in High Efficiency
Authors: Zhong Lieshuang , Chen Huan , Zhu Lingmei , Zhou Maolin , Zhang Lei , Wang Shaomin , Han Xuefeng , Hou Yongping , Zheng Yongmei 
Published: September 2022

AbstractConstructing surface wetting gradients usually involves complex physical or chemical methods. Here, a novel Gradient‐Janus wire (GJW) can be designed based on the theory of newly Liquid Confined Modification (LCM). In LCM theory, reaction difference will be generated by the confinement of reaction solution, which constructs wettability discrepancy on the same curve surface. Thus a unique continuous Gradient‐Janus wetting region can be constructed in a long range on a 1D wire. It is demonstrated that GJW can propel water droplets to transport the distance of ≈73 mm in 0.9 s, and liquid bridge to 85 mm (the longest among this kind of study) in 0.79 s with peak velocity high up to 237 mm s−1 (over 20 times faster than droplet transport on surface of Sarracenia trichome). The mechanism is attributed to cooperation between imbalanced Laplace pressure and surface tension force to generate the driving force act on droplet, liquid bridge, or column transport, respectively. LCM directs the large‐scale facile fabrication of GJWs within 20 s. A large‐scale GJW array can achieve the high‐efficient transport of water droplet in a wide volume range (few µL to 1 mL), making it potential in fogwater harvesting.
Biofabrication of Human Skin with Its Appendages
Authors: Hosseini Motaharesadat , Koehler Karl R. , Shafiee Abbas 
Published: September 2022

AbstractMuch effort has been made to generate human skin organ in the laboratory. Yet, the current models are limited due to the lack of many critical biological and structural features of the skin. Importantly, these in vitro models lack appendages and fail to recapitulate the whole human skin construction. Thus, engineering a human skin with the capacity to generate all components, including appendages, is a major challenge. This review intends to provide an update on the recent efforts underway to regenerate appendage‐bearing skin organs based on scaffold‐free and scaffold‐based bioengineering approaches. Although the mouse skin equivalents containing hair follicles, sebaceous glands, and sweat glands have been established in vitro, there has been limited success in humans. A combination of biofabricated matrices and cell aggregates, such as organoids, can pave the way for generating skin substitutes with human‐like biological, structural, and physical features. Accordingly, the formation of human skin organoids and reconstruction of vascularized skin equipped with immune cells prompt calls for more scientific research. The generation of appendage‐bearing skin substitutes can be applied in practice for wound healing, hair restoration, and scar treatment.
Nonequilibrium Lattice Dynamics in Photoexcited 2D Perovskites
Authors: Cuthriell Shelby A. , Panuganti Shobhana , Laing Craig C. , Quintero Michael A. , Guzelturk Burak , Yazdani Nuri , Traore Boubacar , Brumberg Alexandra , Malliakas Christos D. , Lindenberg Aaron M. , Wood Vanessa , Katan Claudine , Even Jacky , Zhang Xiaoyi , Kanatzidis Mercouri G. , Schaller Richard D. 
Published: September 2022

AbstractInterplay between structural and photophysical properties of metal halide perovskites is critical to their utility in optoelectronics, but there is limited understanding of lattice response upon photoexcitation. Here, 2D perovskites butylammonium lead iodide, (BA)2PbI4, and phenethylammonium lead iodide, (PEA)2PbI4, are investigated using ultrafast transient X‐ray diffraction as a function of optical excitation fluence to discern structural dynamics. Both powder X‐ray diffraction and time‐resolved photoluminescence linewidths narrow over 1 ns following optical excitation for the fluence range studied, concurrent with slight redshifting of the optical bandgaps. These observations are attributed to transient relaxation and ordering of distorted lead iodide octahedra stimulated mainly by electron–hole pair creation. The c axis expands up to 0.37% over hundreds of picoseconds; reflections sampling the a and b axes undergo one tenth of this expansion with the same timescale. Post‐photoexcitation appearance of the (110) reflection in (BA)2PbI4 would suggest a transient phase transition, however, through new single‐crystal XRD, reflections are found that violate glide plane conditions in the reported Pbca structure. The static structure space group is reassigned as P212121. With this, a nonequilibrium phase transition is ruled out. These findings offer increased understanding of remarkable lattice response in 2D perovskites upon excitation.
Local Diverse Polarization Optimized Comprehensive Energy‐Storage Performance in Lead‐Free Superparaelectrics
Authors: Chen Liang , Wang Na , Zhang Zhifei , Yu Huifen , Wu Jie , Deng Shiqing , Liu Hui , Qi He , Chen Jun 
Published: September 2022

AbstractLead‐free dielectric ceramics with ultrahigh energy‐storage performance are the core components used in next‐generation advanced pulse power capacitors. However, the low energy storage density largely hinders their development towards miniaturization, lightweight, and integration. Here, an effective strategy of constructing local diverse polarization is designed in superparaelectrics to realize an ultrahigh energy storage density of ≈10.59 J cm−3 as well as a large efficiency of ≈87.6%. The excellent comprehensive energy‐storage performance is mainly attributed to the design of ultrasmall polar nanoregions with local diverse polarization configuration, confirmed by scanning transmission electron microscopy, leading to the reduced heat loss, substantially enhanced polarization, and breakdown electric field compared to ceramics with single polarization configuration. Benefiting from these features, outstanding temperature/frequency/cycling stability and superior charge/discharge performance (power density ≈187.5 MW cm−3, discharge energy density ≈3.52 J cm−3, discharge rate ≈77 ns) are also achieved. This work demonstrates that local diverse polarization is a super strategy to design new dielectric materials with high energy‐storage performance.
Multifunctionality of Li2SrNb2O7: Memristivity, Tunable Rectification, Ferroelasticity, and Ferroelectricity
Authors: Xu Xianghan , Huang Fei‐Ting , Du Kai , Cheong Sang‐Wook 
Published: September 2022

AbstractLayered Li2SrNb2O7, an inorganic oxide in its bulk single‐crystalline form, is experimentally demonstrated to exhibit multiple structural facets such as ferroelasticity, ferroelectricity, and antiferroelectricity. The transition from a room temperature (RT) centrosymmetric structure to a low‐temperature out‐of‐plane ferroelectric and in‐plane antiferroelectric structure and the low‐temperature (LT) ferroelectric domain configuration are unveiled in TEM, piezoresponse force microscopy, and polarization loop studies. Li2SrNb2O7 also exhibits highly tunable ferroelasticity and excellent Li+ in‐plane conduction, which leads to a giant in‐plane memristor behavior and an in‐plane electronic conductivity increase by three orders of magnitude by electric poling at room RT). The accumulation of Li+ vacancies at the crystal–electrode interface is visualized using in situ optical microscopy. The Li‐ionic biased state shows a clear in‐plane rectification effect combined with a significant relaxation upon time at RT. Relaxation can be fully suppressed at LTs such as 200 K, and utilizing an electric field cooling, a stable rectification can be achieved at 200 K. The results shed light on the selective control of multifunctionalities such as ferroelasticity, ferroelectricity, and ionic‐migration‐mediated effects (a memristor effect and rectification) in a single‐phase bulk material utilizing, for example, different directions, temperatures, frequencies, and magnitudes of electric field.
Minimizing the Programming Power of Phase Change Memory by Using Graphene Nanoribbon Edge‐Contact
Authors: Wang Xiujun , Song Sannian , Wang Haomin , Guo Tianqi , Xue Yuan , Wang Ruobing , Wang HuiShan , Chen Lingxiu , Jiang Chengxin , Chen Chen , Shi Zhiyuan , Wu Tianru , Song Wenxiong , Zhang Sifan , Watanabe Kenji , Taniguchi Takashi , Song Zhitang , Xie Xiaoming 
Published: September 2022

AbstractNonvolatile phase‐change random access memory (PCRAM) is regarded as one of the promising candidates for emerging mass storage in the era of Big Data. However, relatively high programming energy hurdles the further reduction of power consumption in PCRAM. Utilizing narrow edge‐contact of graphene can effectively reduce the active volume of phase change material in each cell, and therefore realize low‐power operation. Here, it demonstrates that the power consumption can be reduced to ≈53.7 fJ in a cell with ≈3 nm‐wide graphene nanoribbon (GNR) as edge‐contact, whose cross‐sectional area is only ≈1 nm2. It is found that the polarity of the bias pulse determines its cycle endurance in the asymmetric structure. If a positive bias is applied to the graphene electrode, the endurance can be extended at least one order longer than the case with a reversal of polarity. In addition, the introduction of the hexagonal boron nitride (h‐BN) multilayer leads to a low resistance drift and a high programming speed in a memory cell. The work represents a great technological advance for the low‐power PCRAM and can benefit in‐memory computing in the future.
Performance of turf‐type bermudagrass cultivars in the upper and lower limits of the European transition zone
Authors: Gómez de Barreda Diego , Azcárraga Carlos , Pornaro Cristina , Macolino Stefano 
Published: September 2022

AbstractBermudagrass [Cynodon dactylon (L.) Pers.] is one of the most widely cultivated turfgrass species throughout the world. It has several important attributes, such as heat and drought tolerance, and one big disadvantage, which is susceptibility to cold temperatures. Although many seeded bermudagrass cultivars are widely used in Europe, research is warranted on new varieties released in recent decades. Two identical field studies were conducted in Valencia, Spain (39° N lat) and Legnaro, Italy (45° N lat) to evaluate the turfgrass quality, winter dormancy, and spring green‐up of two new bermudagrass releases in Europe (‘Arden 15’ and ‘MBG 002’) and three older bermudagrasses (‘Blackjack’, ‘Common’, and ‘Paul 1’). Even though bermudagrasses were successfully cultivated in the cooler temperature zone (45° N lat), cultivars exhibited poorer establishment and longer winter dormancy as a consequence of the lower temperatures compared with those grown in the warmer temperature zone (39° N lat). Cultivars Arden 15 and MBG 002 were able to mitigate the effects of low temperature that affected the older cultivars, especially during spring green‐up, which is an essential characteristic when growing bermudagrass in the upper limit of the transition zone.
Deep vicariance and frequent transoceanic dispersal shape the evolutionary history of a globally distributed fern family
Authors: Testo Weston L. , de Gasper André L. , Molino Sonia , Galán José María Gabriel y , Salino Alexandre , Dittrich Vinícius Antonio de Oliveira , Sessa Emily B. 
Published: September 2022

AbstractPremiseThe historical biogeography of ferns is typically expected to be dominated by long‐distance dispersal due to their minuscule spores. However, few studies have inferred the historical biogeography of a large and widely distributed group of ferns to test this hypothesis. Our aims were to determine the extent to which long‐distance dispersal vs. vicariance have shaped the history of the fern family Blechnaceae, to explore ecological correlates of dispersal and diversification, and to determine whether these patterns differ between the northern and southern hemispheres.MethodsWe used sequence data for three chloroplast loci to infer a time‐calibrated phylogeny for 154 of 265 species of Blechnaceae, including representatives of all genera in the family. This tree was used to conduct ancestral range reconstruction and stochastic character mapping, estimate diversification rates, and identify ecological correlates of diversification.ResultsBlechnaceae originated in Eurasia and began diversifying in the late Cretaceous. A lineage comprising most extant diversity diversified principally in the austral Pacific region around the Paleocene–Eocene Thermal Maximum. Land connections that existed near the poles during periods of warm climates likely facilitated migration of several lineages, with subsequent climate‐mediated vicariance shaping current distributions. Long‐distance dispersal is frequent and asymmetrical, with New Zealand/Pacific Islands, Australia, and tropical America being major source areas.ConclusionsAncient vicariance and extensive long‐distance dispersal have shaped the history of Blechnaceae in both the northern and southern hemispheres. The exceptional diversity in austral regions appears to reflect rapid speciation in these areas; mechanisms underlying this evolutionary success remain uncertain.
Elements of morphology: Standard terminology for the trunk and limbs
Authors: Biesecker Leslie G. , Adam Margaret P. , Chung Brian Hon‐Yin , Kosaki Kenjiro , Menke Leonie A. , White Susan M. , Carey John C. , Hennekam Raoul C. M. 
Published: September 2022

AbstractAn international group of clinicians working in the field of dysmorphology has initiated the standardization of terms used to describe human morphology. The goals are to standardize these terms and reach consensus regarding their definitions. In this way, we will increase the utility of descriptions of the human phenotype and facilitate reliable comparisons of findings among patients. Additional discussions with other workers in dysmorphology and related fields, such as developmental biology and molecular genetics, will become more precise. Here we introduce the anatomy of the trunk and limbs and define and illustrate the terms that describe the major characteristics of these body regions.
Copper‐catalyzed C(sp3)−H/N−H Cross Dehydrogenative Coupling Between Toluene Derivatives and Picolinamides
Authors: Ji Huihui , Zhan Hongju , Chen Shumin , Fang Zeguo , Zhang Qian , Li Dong 
Published: September 2022

AbstractAn efficient C−N bond formation method through copper‐catalyzed C(sp3)−H/N−H cross dehydrogenative coupling between toluene derivatives and picolinamides was developed. The N−H bond of picolinamides was activated by the direction of pyridyl group without influence of remote C−H bonds. The method was applicable to a broad range of substrates with good functional group compatibility, which provided a novel route to prepare N‐benzyl tertiary amides from cheap and readily available starting materials.
Young Australians' labour market engagement and job aspiration in the wake of the COVID‐19 pandemic
Authors: Dinku Yonatan , Yap Mandy 
Published: September 2022

AbstractYoung people tend to bear the brunt of adverse employment consequences of a crisis due mainly to the precarious nature of their job and their over‐representation among jobseekers who are having to find employment when jobs are scarce. Using quarterly welfare payment data for the period 2019–2021 from the Department of Social Services, we noted a marked increase in the percentage of 16‐ to 21‐year‐olds who received youth allowance (other) payments. While a greater proportion of Indigenous youth than non‐Indigenous youth received the payments from 2019 to 2021, the gap widened following the outbreak of the pandemic. Further, applying regression analysis to data from the 2019 and 2020 waves of the 2015 Cohort of the Longitudinal Study of Australian Youth (LSAY), we find no statistically significant change in individual‐level labour force status between 2019 and 2020. However, pandemic‐induced labour market crises appear to have been associated with reduced work hours, heightened career concerns and sustained nonemployment, where potential impacts are larger among traditionally vulnerable youth groups such as female, Indigenous and overseas‐born young persons. The study highlights the need for recognising the intersectionality of youth and other forms of identity (such as gender, Indigenous status and nativity) while designing labour market policies.
Dearomative (3+2) Cycloadditions between Indoles and Vinyldiazo Species Enabled by a Red‐Shifted Chromium Photocatalyst
Authors: Gall Bradley K. , Smith Avery K. , Ferreira Eric M. 
Published: September 2022

AbstractA direct dearomative photocatalyzed (3+2) cycloaddition between indoles and vinyldiazo reagents is described. The transformation is enabled by the development of a novel oxidizing CrIII photocatalyst, its specific reactivity attributed to increased absorptive properties over earlier Cr analogs and greater stability than Ru counterparts. A variety of fused indoline compounds are synthesized using this method, including densely functionalized ring systems that are feasible due to base‐free conditions. Experimental insights corroborate a cycloaddition initiated by nucleophilic attack at C3 of the indole radical cation by the vinyldiazo species.
Affinity Bioorthogonal Chemistry (ABC) Tags for Site‐Selective Conjugation, On‐Resin Protein‐Protein Coupling, and Purification of Protein Conjugates
Authors: Scinto Samuel L. , Reagle Tyler R. , Fox Joseph M. 
Published: September 2022

AbstractThe site‐selective functionalization of proteins has broad application in chemical biology, but can be limited when mixtures result from incomplete conversion or the formation of protein containing side products. It is shown here that when proteins are covalently tagged with pyridyl‐tetrazines, the nickel‐iminodiacetate (Ni‐IDA) resins commonly used for His‐tags can be directly used for protein affinity purification. These Affinity Bioorthogonal Chemistry (ABC) tags serve a dual role by enabling affinity‐based protein purification while maintaining rapid kinetics in bioorthogonal reactions. ABC‐tagging works with a range of site‐selective bioconjugation methods with proteins tagged at the C‐terminus, N‐terminus or at internal positions. ABC‐tagged proteins can also be purified from complex mixtures including cell lysate. The combination of site‐selective conjugation and clean‐up with ABC‐tagged proteins also allows for facile on‐resin reactions to provide protein‐protein conjugates.
Quantum dots in the biomedical world: A smart advanced nanocarrier for multiple venues application
Authors: Singh Siddharth , Raina Deepika , Rishipathak Dinesh , Babu Kamesh R. , Khurana Riya , Gupta Yogesh , Garg Kartik , Rehan Farah , Gupta Shraddha M. 
Published: September 2022

AbstractQuantum dots (QDs) are semiconducting nanoparticles having different optical and electrical properties when compared to larger particles. They exhibit photoluminescence when irradiated with ultraviolet light, which is due to the transition of an excited electron from the valence band to the conductance band followed by the return of the exciting electron back into the valence band. The size and material of QDs can affect their optical and other properties too. The QDs possess special attributes like high brightness, protection from photobleaching, photostability, color tunability, low toxicity, low production cost, a multiplexing limit, and a high surface‐to‐volume proportion, which make them a promising tool for biomedical applications. Here, in this study, we summarize the utilization of QDs in different applications including bioimaging, diagnostics, immunostaining, single‐cell analysis, drug delivery, and protein detection. Moreover, we discuss the advantages and challenges of using QDs in biomedical applications when compared with other conventional tools.