bluuebunny/crossref_metadata_2025_split huggingface dataset:
Active electrochemical high-contrast gratings as on/off switchable and color tunable pixels
Authors: Moon Cheon Woo , Kim Youngji , Hyun Jerome Kartham 
Published: June 2022

AbstractTo be viable for display applications, active structural colors must be electrically tunable, on/off switchable, and reversible. Independently controlling the first two functions, however, is difficult because of causality that ties the real and imaginary parts of the optical constants or changing overlap of fields during structural variations. Here, we demonstrate an active reflective color pixel that encompasses separate mechanisms to achieve both functions reversibly by electrochemically depositing and dissolving Cu inside the dielectric grating slits on a Pt electrode with ΔV < 3 V. Varying the modal interference via Cu occupancy in the slits changes the CIE space coverage by up to ~72% under cross-polarized imaging. In the same pixel, depolarization and absorption by the dissolving porous Cu switches the color off with a maximum contrast of ~97%. Exploiting these results, we demonstrate an active color-switching display and individually addressable on/off pixel matrix that highlights their potential in reflective display applications.
Topological invariant and anomalous edge modes of strongly nonlinear systems
Authors: Zhou Di , Rocklin D. Zeb , Leamy Michael , Yao Yugui 
Published: June 2022

AbstractDespite the extensive studies of topological states, their characterization in strongly nonlinear classical systems has been lacking. In this work, we identify the proper definition of Berry phase for nonlinear bulk waves and characterize topological phases in one-dimensional (1D) generalized nonlinear Schrödinger equations in the strongly nonlinear regime, where the general nonlinearities are beyond Kerr-like interactions. Without utilizing linear analysis, we develop an analytic strategy to demonstrate the quantization of nonlinear Berry phase due to reflection symmetry. Mode amplitude itself plays a key role in nonlinear modes and controls topological phase transitions. We then show bulk-boundary correspondence by identifying the associated nonlinear topological edge modes. Interestingly, anomalous topological modes decay away from lattice boundaries to plateaus governed by fixed points of nonlinearities. Our work opens the door to the rich physics between topological phases of matter and nonlinear dynamics.
Anatomy of Omicron BA.1 and BA.2 neutralizing antibodies in COVID-19 mRNA vaccinees
Authors: Andreano Emanuele , Paciello Ida , Marchese Silvia , Donnici Lorena , Pierleoni Giulio , Piccini Giulia , Manganaro Noemi , Pantano Elisa , Abbiento Valentina , Pileri Piero , Benincasa Linda , Giglioli Ginevra , Leonardi Margherita , Maes Piet , De Santi Concetta , Sala Claudia , Montomoli Emanuele , De Francesco Raffaele , Rappuoli Rino 
Published: June 2022

AbstractSARS-CoV-2 vaccines, administered to billions of people worldwide, mitigate the effects of the COVID-19 pandemic, however little is known about the molecular basis of antibody cross-protection to emerging variants, such as Omicron BA.1, its sublineage BA.2, and other coronaviruses. To answer this question, 276 neutralizing monoclonal antibodies (nAbs), previously isolated from seronegative and seropositive donors vaccinated with BNT162b2 mRNA vaccine, were tested for neutralization against the Omicron BA.1 and BA.2 variants, and SARS-CoV-1 virus. Only 14.2, 19.9 and 4.0% of tested antibodies neutralize BA.1, BA.2, and SARS-CoV-1 respectively. These nAbs recognize mainly the SARS-CoV-2 receptor binding domain (RBD) and target Class 3 and Class 4 epitope regions on the SARS-CoV-2 spike protein. Interestingly, around 50% of BA.2 nAbs did not neutralize BA.1 and among these, several targeted the NTD. Cross-protective antibodies derive from a variety of germlines, the most frequents of which were the IGHV1-58;IGHJ3-1, IGHV2-5;IGHJ4-1 and IGHV1-69;IGHV4-1. Only 15.6, 20.3 and 7.8% of predominant gene-derived nAbs elicited against the original Wuhan virus cross-neutralize Omicron BA.1, BA.2 and SARS-CoV-1 respectively. Our data provide evidence, at molecular level, of the presence of cross-neutralizing antibodies induced by vaccination and map conserved epitopes on the S protein that can inform vaccine design.
Dynamic interaction of BRCA2 with telomeric G-quadruplexes underlies telomere replication homeostasis
Authors: Lee Junyeop , Sung Keewon , Joo So Young , Jeong Jun-Hyeon , Kim Seong Keun , Lee Hyunsook 
Published: June 2022

AbstractBRCA2-deficient cells precipitate telomere shortening upon collapse of stalled replication forks. Here, we report that the dynamic interaction between BRCA2 and telomeric G-quadruplex (G4), the non-canonical four-stranded secondary structure, underlies telomere replication homeostasis. We find that the OB-folds of BRCA2 binds to telomeric G4, which can be an obstacle during replication. We further demonstrate that BRCA2 associates with G-triplex (G3)-derived intermediates, which are likely to form during direct interconversion between parallel and non-parallel G4. Intriguingly, BRCA2 binding to G3 intermediates promoted RAD51 recruitment to the telomere G4. Furthermore, MRE11 resected G4-telomere, which was inhibited by BRCA2. Pathogenic mutations at the OB-folds abrogated the binding with telomere G4, indicating that the way BRCA2 associates with telomere is innate to its tumor suppressor activity. Collectively, we propose that BRCA2 binding to telomeric G4 remodels it and allows RAD51-mediated restart of the G4-driven replication fork stalling, simultaneously preventing MRE11-mediated breakdown of telomere.
Anomalous thermo-osmotic conversion performance of ionic covalent-organic-framework membranes in response to charge variations
Authors: Xian Weipeng , Zuo Xiuhui , Zhu Changjia , Guo Qing , Meng Qing-Wei , Zhu Xincheng , Wang Sai , Ma Shengqian , Sun Qi 
Published: June 2022

AbstractIncreasing the charge density of ionic membranes is believed to be beneficial for generating high output osmotic energy. Herein, we systematically investigated how the membrane charge populations affect permselectivity by decoupling their effects from the impact of the pore structure using a multivariate strategy for constructing covalent-organic-framework membranes. The thermo-osmotic energy conversion efficiency is improved by increasing the membrane charge density, affording 210 W m−2 with a temperature gradient of 40 K. However, this enhancement occurs only within a narrow window, and subsequently, the efficiency plateaued beyond a threshold density (0.04 C m−2). The complex interplay between pore-pore interactions in response to charge variations for ion transport across the upscaled nanoporous membranes helps explain the obtained results. This study has far-reaching implications for the rational design of ionic membranes to augment energy extraction rather than intuitively focusing on achieving high densities.
Optimising the classification of feature-based attention in frequency-tagged electroencephalography data
Authors: Renton Angela I. , Painter David R. , Mattingley Jason B. 
Published: June 2022

AbstractBrain-computer interfaces (BCIs) are a rapidly expanding field of study and require accurate and reliable real-time decoding of patterns of neural activity. These protocols often exploit selective attention, a neural mechanism that prioritises the sensory processing of task-relevant stimulus features (feature-based attention) or task-relevant spatial locations (spatial attention). Within the visual modality, attentional modulation of neural responses to different inputs is well indexed by steady-state visual evoked potentials (SSVEPs). These signals are reliably present in single-trial electroencephalography (EEG) data, are largely resilient to common EEG artifacts, and allow separation of neural responses to numerous concurrently presented visual stimuli. To date, efforts to use single-trial SSVEPs to classify visual attention for BCI control have largely focused on spatial attention rather than feature-based attention. Here, we present a dataset that allows for the development and benchmarking of algorithms to classify feature-based attention using single-trial EEG data. The dataset includes EEG and behavioural responses from 30 healthy human participants who performed a feature-based motion discrimination task on frequency tagged visual stimuli.
Using archaeological data for the understanding of Late-Holocene Sea of Galilee’s level fluctuations
Authors: Giaime Matthieu , Artzy Michal 
Published: June 2022

AbstractIn the Jordan Valley, reconstructed changes of the Sea of Galilee level have shown sharp fluctuations of the water elevation during the Holocene. In this paper, we provide new data originating from the excavations of Kursi Beach archaeological site located on the eastern shore of the Sea of Galilee and compare them with other data gathered from the archaeological site of Magdala, located on its western shore. Our data yield to constrain Sea of Galilee level changes between the Iron Age II (10th–9th centuries BCE) and the Crusader period (11th–12th centuries CE), a period of high interest for the archaeological community. We demonstrate that water level was around -212 to -210 m mean sea level (msl) for the Iron Age II period. Lake level rose to -208/-209 m msl during the Late Hellenistic/Early Roman period. Water level remained low (<-213/-214 m msl) from the Byzantine to the Crusader period (from 5th to 12th centuries CE). Our data provide new knowledge for the understanding of variations in the Sea of Galilee level in antiquity. We highlight that water level fluctuations must have been key factors taken into account in the habitation pattern.
Olfactory distortions in the general population
Authors: Olofsson Jonas K. , Ekesten Fredrik , Nordin Steven 
Published: June 2022

AbstractParosmia, distorted smell sensations, is a common consequence of respiratory virus infections. The phenomenon is not well understood in terms of its impact and long-term outcomes. We examined self-reported experiences of parosmia in a population-based sample from the Betula study that was conducted in Umeå in northern Sweden (baseline data collected in 1998–2000). We used a baseline sample of 2168 individuals aged 35–90 years and with no cognitive impairment at baseline. We investigated the prevalence of parosmia experiences and, using regression analyses, its relationship to other olfactory and cognitive variables and quality of life. Benefitting from the longitudinal study design, we also assessed the persistence of parosmia over 5 and 10 years prospectively. Parosmia experiences were prevalent in 4.8% of the population and it often co-occurred with phantosmia (“olfactory hallucinations”), but was not associated with lower self-rated overall quality of life or poor performance on olfactory or cognitive tests. For some individuals, parosmia was retained 5 years (17.0%) or even 10 years later (10.3%). Thus, parosmia experiences are commonly reported in the population, and can be persistent for some individuals, but might be mostly benign in nature. Our work complements research on clinical-level parosmia, which is typically more severe, and recent parosmia reports during the COVID-19 pandemic, where long-term outcomes are still unknown.
Early dexamethasone use as a protective measure in non-mechanically ventilated critically ill patients with COVID-19: a multicenter, cohort study
Authors: Al Sulaiman Khalid , Korayem Ghazwa B. , Eljaaly Khalid , Altebainawi Ali F. , Al Harbi Omar , Badreldin Hisham A. , Al Harthi Abdullah , Al Yousif Ghada , Vishwakarma Ramesh , Albelwi Shorouq , Almutairi Rahaf , Almousa Maha , Alghamdi Razan , Alhubaishi Alaa , Alissa Abdulrahman , Alharbi Aisha , Algarni Rahmah , Al Homaid Sarah , Al Qahtani Khawla , Akhani Nada , Al Atassi Abdulaleam , Al Ghamdi Ghassan , Aljuhani Ohoud 
Published: June 2022

AbstractDexamethasone showed mortality benefits in patients with COVID-19. However, the optimal timing for dexamethasone initiation to prevent COVID-19 consequences such as respiratory failure requiring mechanical ventilation (MV) is debatable. As a result, the purpose of this study is to assess the impact of early dexamethasone initiation in non-MV critically ill patients with COVID19. This is a multicenter cohort study including adult patients with confirmed COVID-19 admitted to intensive care units (ICUs) and received systemic dexamethasone between March 2020 and March 2021. Patients were categorized into two groups based on the timing for dexamethasone initiation (early vs. late). Patients who were initiated dexamethasone within 24 h of ICU admission were considered in the early group. The primary endpoint was developing respiratory failure that required MV; other outcomes were considered secondary. Propensity score matching (1:1 ratio) was used based on the patient’s SOFA score, MV status, prone status, and early use of tocilizumab within 24 h of ICU admission. Among 208 patients matched using propensity score, one hundred four patients received dexamethasone after 24 h of ICU admission. Among the non-mechanically ventilated patients, late use of dexamethasone was associated with higher odds of developing respiratory failure that required MV (OR [95%CI]: 2.75 [1.12, 6.76], p = 0.02). Additionally, late use was associated with longer hospital length of stay (LOS) (beta coefficient [95%CI]: 0.55 [0.22, 0.88], p = 0.001). The 30-day and in-hospital mortality were higher in the late group; however, they were not statistically significant. In non-mechanically ventilated patients, early dexamethasone use within 24 hours of ICU admission in critically ill patients with COVID-19 could be considered a proactive protective measure.
Tracing the introduction history of the tulip that went wild (Tulipa sylvestris) in sixteenth-century Europe
Authors: Stefanaki Anastasia , Walter Tilmann , van Andel Tinde 
Published: June 2022

AbstractTulipa sylvestris, commonly called the “wild tulip”, was introduced from the Mediterranean to northern Europe in the sixteenth century and became widely naturalized. Research has focused on tulips that came from the Ottoman Empire, but the introduction path of this native European, early ornamental tulip is unclear, and so is its taxonomic status: three subspecies are provisionally accepted, sometimes treated as species. Here we elucidate the history of introduction ofT. sylvestrisand discuss its taxonomy based on our historical findings. The first bulbs came from Bologna (northern Italy) and Montpellier (southern France) in the 1550–1570 s. Several renowned botanists were involved in their introduction, namely Gessner, Wieland, Aldrovandi, De Lobel, Clusius, and Dodoens. There were various introduction routes, including one from Spain which was apparently unsuccessful. The strong sixteenth-century Flemish botanical network facilitated the introduction and naturalization ofT. sylvestrisacross Europe. Based on the latest tulip taxonomy, the diploid subspeciesaustralisis native in the Mediterranean, and the tetraploidsylvestrisis naturalized over Europe, but our historical findings show that bothsylvestrisandaustraliswere introduced to northern Europe. This underlines the need to reconsider the taxonomic status ofT. sylvestris, highlighting the importance of botanical history in understanding the complex taxonomy of naturalized cultivated plants.
Predictive factors for the presence and long-term persistence of SARS-CoV-2 antibodies in healthcare and university workers
Authors: Grégoire Céline , Huynen Pascale , Gofflot Stéphanie , Seidel Laurence , Maes Nathalie , Vranken Laura , Delcour Sandra , Moutschen Michel , Hayette Marie-Pierre , Kolh Philippe , Melin Pierrette , Beguin Yves 
Published: June 2022

AbstractWhile patient groups at risk for severe COVID-19 infections are now well identified, the risk factors associated with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) transmission and immunization are still poorly understood. In a cohort of staff members of a Belgian tertiary academic hospital tested for SARS-CoV-2 antibodies during the early phase of the pandemic and followed-up after 6 weeks, 3 months and 10 months, we collected personal, occupational and medical data, as well as symptoms based on which we constructed a COVID-19 score. Seroprevalence was higher among participants in contact with patients or with COVID-19 confirmed subjects or, to a lesser extent, among those handling respiratory specimens, as well as among participants reporting an immunodeficiency or a previous or active hematological malignancy, and correlated with several symptoms. In multivariate analysis, variables associated with seropositivity were: contact with COVID-19 patients, immunodeficiency, previous or active hematological malignancy, anosmia, cough, nasal symptoms, myalgia, and fever. At 10 months, participants in contact with patients and those with higher initial COVID-19 scores were more likely to have sustained antibodies, whereas those with solid tumors or taking chronic medications were at higher risk to become seronegative.
Assessment of self-doped poly (5-nitro-2-orthanilic acid) as a scaling inhibitor to control the precipitation of CaCO3 and CaSO4 in solution
Authors: Hassan Hammed H. A. M. , Abd-El-Khalek Dalia E. , Abdel Fattah Marwa 
Published: June 2022

AbstractSelf-doped- and nitro-polyanilines have become a widely used strategy to optimize the electronic and vibratory spectra of polymeric building blocks in various applications. We report the synthesis of poly (5-nitro-2-orthanilic acid) by an aniline-initiated oxidative polymerization reaction. The polymer is characterized by spectroscopic techniques, elemental shapes, cyclic voltammetry, electrical conductivity, and microscopic and thermal measurements. The hydrophilic and hydrophobic nature of the supports provided the formation of amphiphilicity as judged by SEM. Thermogravimetric measurements reveal thermal stability up to 500 °C and glass temperature (Tg) observed at 240 °C. Electrical conductivity decreases as the temperature rises at the different frequencies used, reflecting the semiconducting nature in the extrinsic range, which is characterized by high carriers and low mobility. The presence of these electron residues causes a decrease in efficiency and increases the thermal conductivity. Dielectric measurements have shown that permittivity decreases gradually at lower levels, mainly due to the transport of charging carriers, resulting in higher performance. The testing of the copolymer as a new scale blocker has resulted in moderate to fairly high performance. This effect is attributed to the change in polymer geometry using intramolecular H-bonding group -SO3H and a chain polymer in an aqueous medium.
Large-magnitude (VEI ≥ 7) ‘wet’ explosive silicic eruption preserved a Lower Miocene habitat at the Ipolytarnóc Fossil Site, North Hungary
Authors: Karátson Dávid , Biró Tamás , Portnyagin Maxim , Kiss Balázs , Paquette Jean-Louis , Cseri Zoltán , Hencz Mátyás , Németh Károly , Lahitte Pierre , Márton Emő , Kordos László , Józsa Sándor , Hably Lilla , Müller Samuel , Szarvas Imre 
Published: June 2022

AbstractDuring Earth’s history, geosphere-biosphere interactions were often determined by momentary, catastrophic changes such as large explosive volcanic eruptions. The Miocene ignimbrite flare-up in the Pannonian Basin, which is located along a complex convergent plate boundary between Europe and Africa, provides a superb example of this interaction. In North Hungary, the famous Ipolytarnóc Fossil Site, often referred to as “ancient Pompeii”, records a snapshot of rich Early Miocene life buried under thick ignimbrite cover. Here, we use a multi-technique approach to constrain the successive phases of a catastrophic silicic eruption (VEI ≥ 7) dated at 17.2 Ma. An event-scale reconstruction shows that the initial PDC phase was phreatomagmatic, affecting ≥ 1500 km2 and causing the destruction of an interfingering terrestrial–intertidal environment at Ipolytarnóc. This was followed by pumice fall, and finally the emplacement of up to 40 m-thick ignimbrite that completely buried the site. However, unlike the seemingly similar AD 79 Vesuvius eruption that buried Pompeii by hot pyroclastic density currents, the presence of fallen but uncharred tree trunks, branches, and intact leaves in the basal pyroclastic deposits at Ipolytarnóc as well as rock paleomagnetic properties indicate a low-temperature pyroclastic event, that superbly preserved the coastal habitat, including unique fossil tracks.
Signature of weak-antilocalization in sputtered topological insulator Bi2Se3 thin films with varying thickness
Authors: Gautam Sudhanshu , Aggarwal V. , Singh Bheem , Awana V. P. S. , Ganesan Ramakrishnan , Kushvaha S. S. 
Published: June 2022

AbstractWe report a low-temperature magneto transport study of Bi2Se3 thin films of different thicknesses (40, 80 and 160 nm), deposited on sapphire (0001) substrates, using radio frequency magnetron sputtering technique. The high-resolution x-ray diffraction measurements revealed the growth of rhombohedral c-axis {0003n} oriented Bi2Se3 films on sapphire (0001). Vibrational modes of Bi2Se3 thin films were obtained in the low wavenumber region using Raman spectroscopy. The surface roughness of sputtered Bi2Se3 thin films on sapphire (0001) substrates were obtained to be ~ 2.26–6.45 nm. The chemical and electronic state of the deposited Bi2Se3 was confirmed by X-ray photoelectron spectroscopy and it showed the formation of Bi2Se3 compound. Resistivity versus temperature measurements show the metallic nature of Bi2Se3 films and a slight up-turn transition in resistivity at lower temperatures < 25 K. The positive magneto-resistance value of Bi2Se3 films measured at low temperatures (2–100 K) confirmed the gapless topological surface states in Bi2Se3 thin films. The quantum correction to the magnetoconductivity of thin films in low magnetic field is done by employing Hikami–Larkin–Nagaoka theory and the calculated value of coefficient ‘α’ (defining number of conduction channels) was found to be 0.65, 0.83 and 1.56 for film thickness of 40, 80 and 160 nm, respectively. These observations indicate that the top and bottom surface states are coupled with the bulk states and the conduction mechanism in Bi2Se3 thin films varied with the film thicknesses.
Effect of piston texture at inclination and eccentricity work conditions on damping characteristics of a hydraulic shock absorber
Authors: Yu Yangyang , Zhang Junhong , Meng Xiangde , Wang Dan , Ma Shasha 
Published: June 2022

AbstractIn order to accurately predict the damping characteristics of a hydraulic shock absorber under piston inclination and eccentricity conditions, especially, considering effects of piston surface construction. In present work, taking account of piston slight inclination and eccentricity, a more detailed mathematical model was developed to estimate effects of piston texture on damping characteristics. Based on the mathematical models of reservoir and compression stroke coupled with Reynolds equation, a new damping force model was developed, which analyzed effects of piston structure on damping characteristics. The mathematical models of piston texture, piston slight inclination, piston eccentricity and combinations of three cases are developed to analyzed in detailed effects of piston texture at different work conditions on damping characteristics. The results shown that the friction force of piston increases parabolically with increasing depth ratio, and that of piston increases linearly with increasing area ratio. Piston textures have little effects on damping characteristics at specific structural parameters conditions when piston normal operation, however, textures of slight inclined and eccentric piston have great effects. As a result, piston textures might cause high damping force, destroyed comfort and safety. Therefore, it is necessary that effects of piston surface construction were precisely predicted on damping characteristics under different work conditions. The results might provide a new insight for the design of hydraulic shock absorber and investigation of vehicle system dynamics.