bluuebunny/crossref_metadata_2025_split huggingface dataset:
FG-4592 protects the intestine from irradiation-induced injury by targeting the TLR4 signaling pathway
Authors: Feng Zhenlan , Xu Qinshu , He Xiang , Wang Yuedong , Fang Lan , Zhao Jianpeng , Cheng Ying , Liu Cong , Du Jicong , Cai Jianming 
Published: June 2022

Abstract
Background
Severe ionizing radiation (IR)-induced intestinal injury associates with high mortality, which is a worldwide problem requiring urgent attention. In recent years, studies have found that the PHD-HIF signaling pathway may play key roles in IR-induced intestinal injury, and we found that FG-4592, the PHD inhibitor, has significant radioprotective effects on IR-induced intestinal injury.

Methods
In the presence or absence of FG-4592 treatment, the survival time, pathology, cell viability, cell apoptosis, and organoids of mice after irradiation were compared, and the mechanism was verified after transcriptome sequencing. The data were analyzed using SPSS ver. 19 software.

Results
Our results show that FG-4592 had significant radioprotective effects on the intestine. FG-4592 improved the survival of irradiated mice, inhibited the radiation damage of intestinal tissue, promoted the regeneration of intestinal crypts after IR and reduced the apoptosis of intestinal crypt cells. Through organoid experiments, it is found that FG-4592 promoted the proliferation and differentiation of intestinal stem cells (ISCs). Moreover, the results of RNA sequencing and Western blot showed that FG-4592 significantly upregulated the TLR4 signaling pathway, and FG-4592 had no radioprotection on TLR4 KO mice, suggesting that FG-4592 may play protective role against IR by targeting TLR4.

Conclusion
Our work proves that FG-4592 may promote the proliferation and regeneration of ISCs through the targeted regulation of the TLR4 signaling pathway and ultimately play radioprotective roles in IR-induced injury. These results enrich the molecular mechanism of FG-4592 in protecting cells from IR-induced injury and provide new methods for the radioprotection of intestine.
Xeno-free protocol for GMP-compliant manufacturing of human fetal pancreas-derived mesenchymal stem cells
Authors: Jabbarpour Zahra , Aghayan Sajjad , Arjmand Babak , Fallahzadeh Khadijeh , Alavi-Moghadam Sepideh , Larijani Bagher , Aghayan Hamid Reza 
Published: June 2022

Abstract
Background
Mesenchymal stem cells (MSCs) have been suggested as an appropriate source for diabetes cell-based therapies. The high proliferation and differentiation capacity of fetal MSCs and the role of fetal pancreatic-derived MSCs (FPMSCs) in islet generation make them good candidates for diabetes treatment. To manufacture clinical-grade MSCs, animal-free culture protocols are preferred. The current study aimed to establish a xeno-free/GMP-compliant protocol for FPMSCs manufacturing. The focus was on the effects of fetal bovine serum (FBS) replacement with pooled human serum (HS).

Material and methods
FPMSCs were isolated and expanded from the pancreas of legally aborted fetuses with few modifications in our previously established protocol. The cells were expanded in two different culture media, including DMEM supplemented with 10% FBS or 10% pooled HS. A side-by-side comparison was made to evaluate the effect of each serum on proliferation rate, cell cycle, senescence, multi-lineage differentiation capacity, immunophenotype, and tumorigenesis of FPMSCs.

Results
Flow cytometry analysis and three-lineage differentiation ability demonstrated that fibroblast-like cells obtained from primary culture had MSCs’ characteristics. The FPMSCs displayed similar morphology and CD markers expression in both sera. HS had a higher proliferative effect on FPMSCs than FBS. In FBS, the cells reached senescence earlier. In addition to normal karyotypes and anchorage-dependent growth, in vivo tumor formation was not seen.

Conclusion
Our results demonstrated that HS was a better serum alternative than FBS for in vitro expansion of FPMSCs. Compared with FBS, HS increased FPMSCs’ proliferation rate and decreased their senescence. In conclusion, HS can effectively replace FBS for clinical-grade FPMSCs manufacturing.

Graphical abstract
Are there employment and income gains of a national breast cancer screening program?
Authors: Kambourova Zornitza , Kalwij Adriaan 
Published: June 2022

Abstract
Background
The Dutch national breast cancer screening program invites women aged 50–75 for screening. By detecting the disease in an early phase, the program aims to achieve lower breast cancer mortality and improve breast cancer survivors’ health. Arguably, the latter also improves the employability of diagnosed women.

Objective
This study investigates the effects of the Dutch national breast cancer screening program on diagnosed women’s employment and income.

Methods
The empirical analysis uses data of 229,357 women aged 40–59, of whom 10,515 were diagnosed with breast cancer at an age in the range 47–53. A regression-based difference-in-differences estimator is used to identify program effects by comparing outcomes for women diagnosed at ages 47–49 with the outcomes for those diagnosed at ages 50–53. The empirical models account for individual fixed effects, and for age and year fixed effects by using a control group of women who were not diagnosed with breast cancer.

Results
Women’s employment rates declined in the six-year period after a breast cancer diagnosis with, on average, about 3 percentage points and their incomes declined with, on average, about 5% over this period. The empirical evidence, based on a comparison of outcomes for women diagnosed at ages 47–49 with the outcomes for those diagnosed at ages 50–53 when covered by the breast cancer screening program, does not support that these declines in employment and income were affected by the program. The evidence also does not support short or medium-term survival gains of the program.

Conclusions
The findings of this study suggest that the Dutch national breast cancer screening program yields no discernible short or medium-term employment and income gains for women diagnosed with breast cancer.
Incidence of acute myocardial injury and its association with left and right ventricular systolic dysfunction in critically ill COVID-19 patients
Authors: Jansson Saga , Blixt Patrik Johansson , Didriksson Helen , Jonsson Carina , Andersson Henrik , Hedström Cassandra , Engvall Jan , Aneq Meriam Åstrom , Chew Michelle S. 
Published: June 2022

AbstractBackgroundPrevious studies have found an increase in cardiac troponins (cTns) and echocardiographic abnormalities in patients with COVID-19 and reported their association with poor clinical outcomes. Whether acute injury occurs during the course of critical care and if it is associated with cardiac function is unknown.The purpose of this study was to document the incidence of acute myocardial injury (AMInj) and echocardiographically defined left ventricular (LV) and right ventricular (RV) systolic dysfunction in consecutive patients admitted to an intensive care unit (ICU) for COVID-19. The relationship between AMInj and echocardiographic abnormalities during the first 14 days of ICU admission was studied. Finally, the association between echocardiographic findings, AMInj and clinical outcome was evaluated.MethodsSeventy-four consecutive patients (≥18 years) admitted to the ICU at Linköping University Hospital between 19 Mar 2020 and 31 Dec 2020 for COVID-19 were included. High-sensitivity troponin-T (hsTnT) was measured daily for up to 14 days. Transthoracic echocardiography was conducted within 72 h of ICU admission. Acute myocardial injury was defined as an increased hsTnT > 14ng/l and a > 20% absolute change with or without ischaemic symptoms. LV and RV systolic dysfunction was defined as at least 2 abnormal indicators of systolic function specified by consensus guidelines.ResultsIncreased hsTnT was observed in 59% of patients at ICU admission, and 82% developed AMInj with peak levels at 8 (3–13) days after ICU admission. AMInj was not statistically significantly associated with 30-day mortality but was associated with an increased duration of invasive mechanical ventilation (10 (3–13) vs. 5 days (0–9),p=0.001) as well as ICU length of stay (LOS) (19.5 (11–28) vs. 7 days (5–13),p=0.015). After adjustment for SAPS-3 and admission SOFA score, the effect of AMInj was significant only for the duration of mechanical ventilation (p=0.030).The incidence of LV and RV dysfunction was 28% and 22%, respectively. Only indices of LV and RV longitudinal contractility (mitral and tricuspid annular plane systolic excursion) were associated with AMInj. Echocardiographic parameters were not associated with clinical outcome.ConclusionsMyocardial injury is common in critically ill patients with COVID-19, with AMInj developing in more than 80% after ICU admission. In contrast, LV and RV dysfunction occurred in approximately one-quarter of patients. AMInj was associated with an increased need for mechanical ventilation and ICU LOS but neither AMInj nor ventricular dysfunction was significantly associated with mortality.
Stress and strain among veterinarians: a scoping review
Authors: Pohl Robert , Botscharow Julia , Böckelmann Irina , Thielmann Beatrice 
Published: June 2022

AbstractThe aim of this review is to systematically review studies on work-related stress that may affect the mental health of veterinarians. Studies have indicated a high prevalence of various risk factors for mental disorders among practicing veterinarians. In addition to a high risk of suicide, there is increasing evidence of burnout and depression. A scoping review was conducted using the PubMed, MEDLINE, Scopus, Cochrane Library, Web of Science, PubPsych and PSYNDEX databases. Twenty-one studies (plus seven studies with nonstandardized questionnaires) published between 2000 and 2021 were found that presented data on the effect of workload on the mental wellbeing of veterinarians. All of the included studies indicate a high prevalence of psychological stressors in veterinary practice. The risks of burnout, anxiety and depressive disorders are higher in this occupational group than in the general population and other occupational groups. Subjectively, female veterinarians perceive their psychological workload to be higher than that of their male counterparts. Working hours and ethical dilemmas stand out as major sources of stress. There is a need to improve overall psychological wellbeing of veterinarians. Organizational support services and developing personal strategies for coping with work-related stress can prove helpful.
Low-complexity signal detection networks based on Gauss-Seidel iterative method for massive MIMO systems
Authors: Yao Haifeng , Li Ting , Song Yunchao , Ji Wei , Liang Yan , Li Fei 
Published: June 2022

AbstractIn massive multiple-input multiple-output (MIMO) systems with single- antenna user equipment (SAUE) or multiple-antenna user equipment (MAUE), with the increase of the number of received antennas at base station, the complexity of traditional detectors is also increasing. In order to reduce the high complexity of parallel running of the traditional Gauss-Seidel iterative method, this paper proposes a model-driven deep learning detector network, namely Block Gauss-Seidel Network (BGS-Net), which is based on the Gauss-Seidel iterative method. We reduce complexity by converting a large matrix inversion to small matrix inversions. In order to improve the symbol error ratio (SER) of BGS-Net under MAUE system, we propose Improved BGS-Net. The simulation results show that, compared with the existing model-driven algorithms, BGS-Net has lower complexity and similar the detection performance; good robustness, and its performance is less affected by changes in the number of antennas; Improved BGS-Net can improve the detection performance of BGS-Net.
Blockchain-based multi-skill mobile crowdsourcing services
Authors: Xu Weize , Duan Hongyue , Chen Xiao , Huang Jie , Liu Deyong , Chen Yichao 
Published: June 2022

AbstractWith the boom in 5G technology, mobile spatial crowdsourcing has shown great dynamism in industrial mobile communications and edge computing node management. But the traditional crowdsourcing system is not advanced enough to adapt to the new environment. Typically, traditional crowdsourcing workflow is hosted by a centralized crowdsourcing platform. However, the centralized crowdsourcing platform faces the following problems: (1) single point of failure, (2) user privacy leakage, (3) subjective arbitration, (4) additional service fee, and (5) non-transparent task assignment process. To improve those problems, we replaced the centralized crowdsourcing platform with a decentralized blockchain infrastructure. And we analyzed the challenge problems of multi-skilled spatial crowdsourcing tasks in the blockchain crowdsourcing system. In addition, a crowdsourcing task allocation algorithm has been proposed, which implements a transparent task distribution process and can adapt to the computing-constrained environment on the blockchain. Compared with the TSWCrowd blockchain-based crowdsourcing model, our system has a higher task allocation rate under the same conditions. And the experimental result shows our work has good economic feasibility, which decentralizes the crowdsourcing process and significantly reduces the additional consumption of the crowdsourcing process.
Cloud accounting adoption in Thai SMEs amid the COVID-19 pandemic: an explanatory case study
Authors: Sastararuji Dalinee , Hoonsopon Danupol , Pitchayadol Pongsakorn , Chiwamit Pimsiri 
Published: June 2022

AbstractThe COVID-19 pandemic has altered the way small and medium-sized businesses (SMEs) function. To maintain business efficiency and reduce operating costs in the context of the constraints imposed by the pandemic, SMEs have been forced to embrace new digital technologies. Cloud accounting is becoming an increasingly important business operating tool for SMEs. By adopting cloud-based accounting, SMEs can become more efficient, financially organized, and flexible. This study aims to investigate the factors that have a pervasive influence on cloud accounting adoption among SMEs in Thailand, following the pandemic's effects. This study integrates three technology adoption theories—the Technology–Organization–Environment framework, Diffusion of Innovation theory, and Institutional Theory—and studies them alongside SMEs' unique characteristics. The research employs a qualitative case study method and triangulated sources of evidence. The findings provide important implications for the research community, policymakers, cloud accounting vendors, and SME owners aiming to formulate better approaches to cloud accounting adoption after the pandemic. The results suggest that vendors should focus on SMEs' particular characteristics and needs. By contrast, SMEs should determine the organizational fit of the cloud accounting platform and integrate cloud accounting with other aspects of their operations.
Relational capital and strategic orientations as antecedents of innovation: evidence from Mexican SMEs
Authors: Ramírez-Solis Edgar R. , Llonch-Andreu Joan , Malpica-Romero Alberto D. 
Published: June 2022

AbstractQuestions "Where does innovation initiate in a company?" and "How can a small and medium-sized enterprise (SME) leverage its different resources to enhance its innovation capabilities to outperform its competitors?" remain unanswered to date. Accordingly, this study examined the relationship between the firm's relational capital and fundamental strategic orientations that a firm can adopt and how these different orientations affect innovation and organizational performance. The target sample included 360 Mexican SMEs who completed a pen-and-pencil questionnaire conducted at the four main cities of this country. Structural equation modeling was performed, and results revealed a strong positive effect of relational capital over all four strategic orientations considered in this study. However, mixed findings of strategic orientations and innovation were obtained. Although market and entrepreneurial orientation positively influenced innovation, a negative relationship was found between learning orientation and innovation and a nonsignificant relationship between technology orientation and innovation. As expected, innovation positively influenced the performance of SMEs. This study offers essential academic contributions and interesting managerial insights to improve performance using relational capital through innovation and strategic orientations. Therefore, we propose relational capital as an underexploited resource and a source of innovation for SMEs.
Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients
Authors: Baier Claas , Huang Jiabin , Reumann Kerstin , Indenbirken Daniela , Thol Felicitas , Koenecke Christian , Ebadi Ella , Heim Albert , Bange Franz-Christoph , Haid Sibylle , Pietschmann Thomas , Fischer Nicole 
Published: June 2022

Abstract
Background
Respiratory syncytial virus (RSV) causes community-acquired respiratory tract infections during winter. However, outbreaks in hospitals also occur repeatedly. In particular, patients with hematologic malignancies are at an increased risk for a severe and potentially fatal course of RSV infection. Here we present the investigation of an RSV outbreak in a hematology ward for adults following the ORION statement.

Methods
An epidemiologic and molecular outbreak analysis was performed. We developed and employed a minimal oligonucleotide probe set in target capture probe sequencing that allows cost-effective RSV-A or -B capturing to reconstruct RSV genomes from clinical samples.

Results
Four adult patients were involved in the outbreak caused by RSV-B in March 2019. The enforcement of the pre-existing infection control measures by effective training of hospital staff contributed to a successful containment. PCR-based RSV screening on the ward enabled early detection of new cases and rapid isolation measures. The molecular analysis demonstrated that the outbreak sequences were highly related and distinct to other RSV-B strains circulating at the same time.

Conclusions
A multimodal infection control concept is essential for the timely detection and control of RSV outbreaks in patients with hematological disease. Among other measures, preventive screening for respiratory viruses is recommended. Furthermore, the integration of conventional and molecular epidemiology, such as whole-genome sequencing and variant calling, significantly contributes to the understanding of transmission pathways. Based on this, appropriate conclusions can be drawn for targeted prevention measures that have prepared us for the COVID-19 pandemic beyond the RSV approach described here.
Say NOPE to social disorganization criminology: the importance of creators in neighborhood social control
Authors: Linning Shannon J. , Olaghere Ajima , Eck John E. 
Published: June 2022

AbstractDespite decades of research into social disorganization theory, criminologists have made little progress developing community programs that reduce crime. The lack of progress is due in part to faulty assumptions in the theory: that neighborhoods are important; that residents are the primary source of control; and that informal social controls are emergent. In this paper we propose an alternative: the neighborhoods out of places explanation (NOPE). NOPE starts with property parcels (i.e., proprietary places), rather than neighborhoods. It focuses on the power and legal authority of people and institutions that own property, rather than on residents. It posits that control is intentional and goal driven, rather than emergent. We refer to those who own and control as creators. This small group of elites shape city areas and residents must adapt to the environments that suppress or facilitate crime. We discuss how shifting our focus to creators provides important new implications for theory, research, and policy in criminology.
Geometry aware physics informed neural network surrogate for solving Navier–Stokes equation (GAPINN)
Authors: Oldenburg Jan , Borowski Finja , Öner Alper , Schmitz Klaus-Peter , Stiehm Michael 
Published: June 2022

AbstractMany real world problems involve fluid flow phenomena, typically be described by the Navier–Stokes equations. The Navier–Stokes equations are partial differential equations (PDEs) with highly nonlinear properties. Currently mostly used methods solve this differential equation by discretizing geometries. In the field of fluid mechanics the finite volume method (FVM) is widely used for numerical flow simulation, so-called computational fluid dynamics (CFD). Due to high computational costs and cumbersome generation of the discretization they are not widely used in real time applications. Our presented work focuses on advancing PDE-constrained deep learning frameworks for more real-world applications with irregular geometries without parameterization. We present a Deep Neural Network framework that generate surrogates for non-geometric boundaries by data free solely physics driven training, by minimizing the residuals of the governing PDEs (i.e., conservation laws) so that no computationally expensive CFD simulation data is needed. We named this method geometry aware physics informed neural network—GAPINN. The framework involves three network types. The first network reduces the dimensions of the irregular geometries to a latent representation. In this work we used a Variational-Auto-Encoder (VAE) for this task. We proposed the concept of using this latent representation in combination with spatial coordinates as input for PINNs. Using PINNs we showed that it is possible to train a surrogate model purely driven on the reduction of the residuals of the underlying PDE for irregular non-parametric geometries. Furthermore, we showed the way of designing a boundary constraining network (BCN) to hardly enforce boundary conditions during training of the PINN. We evaluated this concept on test cases in the fields of biofluidmechanics. The experiments comprise laminar flow (Re = 500) in irregular shaped vessels. The main highlight of the presented GAPINN is the use of PINNs on irregular non-parameterized geometries. Despite that we showed the usage of this framework for Navier Stokes equations, it should be feasible to adapt this framework for other problems described by PDEs.
Decision-making and the trajectories of young Europeans in the London region: the planners, the dreamers, and the accidental migrants
Authors: Koikkalainen Saara , Lulle Aija , King Russell , Leon-Himmelstine Carmen , Szkudlarek Aleksandra 
Published: June 2022

AbstractThis paper focuses on the intra-EU movement of young adults from Finland, Poland, and Spain who have settled, short- or long-term, in London and its wider region. In our comparative analysis, we find that the 46 interviewees differ in the way in which they took the original decision to move to the UK. Study, work, career, life goals, and lifestyle are the main variables shaping, in various combinations, migration decisions and plans. We categorize the decision-making and subsequent trajectories into three groups based on migrants’ life-stories. The first group, the planners, had a long-term plan to move abroad with well-defined objectives of what they hoped to achieve. The second group, the dreamers, had the idea to move abroad someday, but then decided to activate the idea rather suddenly. The third group, the accidental migrants, moved abroad almost by accident, having had no prior plans, but responded to the opportunity when it arose out of a chance event, and had no specific plans as to what they would do abroad. The boundaries between these groups are somewhat blurred and the mobile individual’s attitudes and motivation towards migration may change over time. Examining the decision-making process of current migrants helps to estimate how inbound mobility to the UK from the EU might change in the new post-Brexit migration scenario.