bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do pro-social video games promote moral activity?: an analysis of user reviews of Papers, Please
Authors: Cabellos Beatriz , Pozo Juan-Ignacio , Marín-Rubio Kevin , Sánchez Daniel L. 
Published: May 2022

AbstractVideo games are the digital entertainment resource most in demand by young people, which has led an increasing number of education experts to study their possible benefits. In particular, in this research, we set out to identify the potential of ‘Papers, Please’ to promote moral learning. Thus, we have tried to identify those objectives that go beyond the success in the video game and could favor moral learning. For this purpose, we have investigated what types of moral discourses arise from playing ‘Papers, Please’, a video game where you adopt the role of a customs inspector in a totalitarian state who must obtain the necessary money to fund their family. To do this, we analyzed the moral content of 1,560 player reviews. Results showed that only 4.94% of the reviews presented Moral Intuitions (moral content), which occurred more in the players who had played longer and had declared more Negative Emotions. As for the analysis of the Moral Intuitions, results showed that the players mainly made references to Care for both Family and Immigrants and point out the Authority of the State. However, Fairness/Cheating is less represented, despite the many events related to Immigrant discrimination. Through Exploratory Factor Analysis, we identified three dimensions, one of them pragmatic, oriented to success in the video game, and the others aimed at epistemic aspects beyond the objectives of the video game and that delve into the moral aspects of the game events. Hence, although spontaneous video game use is oriented toward pragmatic goals, ‘Papers, Please’ can guide players to think about the morality of the video game. Nevertheless, if we want to favor moral learning with ‘Papers, Please’, it is necessary to promote epistemic goals aimed at the explicitation of the morality that underlies the video game. To this end, we propose the application of scaffolding that favors these objectives.
Grounding and the Epistemic Regress Problem
Authors: Siscoe Robert Weston 
Published: May 2022

AbstractModal metaphysics consumed much of the philosophical discussion at the turn of the century, yielding a number of epistemological insights. Modal analyses were applied within epistemology, yielding sensitivity and safety theories of knowledge as well as counterfactual accounts of the basing relation. The contemporary conversation has now turned to a new metaphysical notion – grounding – opening the way to a fresh wave of insights by bringing grounding into epistemology. In this paper, I attempt one such application, making sense of the epistemic regress problem in terms of grounding. I argue that the relation that generates the epistemic regress is a grounding relation, showing that grounding can make sense of proposals by epistemic foundationalists and charting the course for similar applications to epistemic coherentism and epistemic infinitism. If it is right that grounding is involved in the epistemic regress, this points the way forward both for epistemologists and metaphysicians, revealing the prospects of solutions to the epistemic regress problem while providing grounding advocates with yet another example of grounding with which to theorize.
Social and emotional characteristics of girls and young women with DDX3X-associated intellectual disability: a descriptive and comparative study
Authors: Ng-Cordell Elise , Kolesnik-Taylor Anna , O’Brien Sinéad , Astle Duncan , Scerif Gaia , Baker Kate 
Published: May 2022

AbstractDDX3Xvariants are a common cause of intellectual disability (ID) in females, and have been associated with autism spectrum disorder and emotional-behavioural difficulties. In this study, we compared phenotypic data for 23 females withDDX3Xvariants, to 23 females with ID and other genetic diagnoses. We found a wide range of adaptive, social and emotional function within theDDX3Xgroup. Autism characteristics did not differ betweenDDX3Xand comparison groups, while levels of anxiety and self-injurious behaviour (SIB) were significantly higher in theDDX3Xgroup. Within theDDX3Xgroup, adaptive function, autism characteristics, anxiety and SIB scores were positively correlated, with evidence for group-specific associations with SIB. Future work is warranted to explore the multilevel mechanisms contributing to social and emotional development in individuals withDDX3Xvariants.
Presence of the Absent Father: Perceptions of Family among Peacekeeper-Fathered Children in the Democratic Republic of Congo
Authors: Wagner Kirstin , Glaesmer Heide , Bartels Susan A. , Weber Sanne , Lee Sabine 
Published: May 2022

AbstractThe United Nations Missions in the Democratic Republic of Congo have faced heavy allegations of peacekeeper-perpetrated sexual exploitation and abuse. Reports indicate that sexual encounters between members of peacekeeping forces and female civilians have resulted in the birth of children; however, no conclusive information on these children exists to date. This is the first study to explore the perspectives of youth who were fathered and abandoned by peacekeepers. We analysed semi-structured interviews with 35 peacekeeper-fathered children (PKFC) regarding their perceptions of family in light of their fathers’ absence. The results show that PKFC’s lack of knowledge about their fathers significantly impacts their self-conception and social identity. Not relying on paternal support was perceived to exacerbate poverty while the inability to uncover paternal roots and family ties presented a barrier to cultural integration. Although increasingly reliant on their maternal family, PKFC received limited care from their mothers’ kin networks, causing some to compare their upbringing to that of orphans. The resulting divergence between participants’ ideals of family and their subjective life experiences created cognitive dissonance which was reduced through a situational attribution of neglect. PKFC without support mechanisms engaged in wishful thinking about relationships to their unknown fathers and increased the value of searching for them. Derived from their hope to overcome hardship, they saw the pursuit of ideal-typical family relations as the route to happiness and financial security. Based on the emotional presence of their absent fathers, we discuss family and identity-related challenges for PKFC and make recommendations for positive change.
Performance and acute procedural outcomes of the EnSite Precision™ cardiac mapping system for electrophysiology mapping and ablation procedures: results from the EnSite Precision™ observational study
Authors: Hsu Jonathan C. , Darden Douglas , Glover Benedict M. , Colley B. Judson , Steinberg Christian , Thibault Bernard , Jewell Coty , Bernard Michael , Tabereaux Paul B. , Siddiqui Usman , Li Jingyun , Horvath Eric E. , Cooper Daniel , Lin David 
Published: May 2022

Abstract
Background
The EnSite Precision™ cardiac mapping system (Abbott) is a catheter navigation and mapping system capable of displaying the three-dimensional (3D) position of conventional and sensor-enabled electrophysiology catheters, as well as displaying cardiac electrical activity as waveform traces and dynamic 3D maps of cardiac chambers. The EnSite Precision™ Observational Study (NCT-03260244) was designed to quantify and characterize the use of the EnSite Precision™ cardiac mapping system for mapping and ablation of cardiac arrhythmias in a real-world environment and evaluate procedural outcomes.

Methods
A total of 1065 patients were enrolled at 38 centers in the USA and Canada between 2017 and 2018 and were followed for 12 months post procedure for arrhythmia recurrence, medication use, and quality-of-life changes. Eligible subjects were adults undergoing a cardiac electrophysiology mapping and radiofrequency ablation procedure using the EnSite Precision™ System.

Results
A final cohort of 925 patients (64.3 years of age, 30.2% female) were analyzed. The primary procedural indication was atrial flutter in 48.1% (445/925), atrial fibrillation in 46.5% (430/925), and other arrhythmias in 5% (50/925). Electroanatomic mapping was performed in 81.5% (754/925) of patients. Mapping was stable throughout 79.8% (738/925) of procedures with initial mapping time of 8.6 min (IQR 4.7–15.0). Average mapping efficiency created with AutoMap or TurboMap was 164.9 ± 365.7 used points per minute. Median number of mapping points collected and used was 1752.5 and 811.0, respectively. Only 335/925 (36.2%) required editing and 66.0% (221/335) of these patients required editing of less than 10 points. Fluoroscopy was utilized in most cases (n = 811/925, 87.4%) with fluoroscopy time of 11.0 min (IQR 6.0–18.0). Overall median procedure time was 101.0 min (IQR 59.0–152.0). Acute procedural success was high for both atrial fibrillation (n = 422/430, 98.1%) and atrial flutter (n = 434/445, 97.5%).

Conclusion
In a real-world study analysis, use of the EnSite Precision™ mapping system was associated with high procedural stability, short mapping times, high point density requiring infrequent editing, low fluoroscopy time, and high prevalence of acute procedural success.
Prevalence and Impact of Fatigue in Children with Primary Immunodeficiency Disorders: a Quantitative Single-Center Study
Authors: Visser Eline , Fraaij Pieter , Hoogenboom Annemieke , Witkamp Erica , van der Knaap Linda , van Rossum Annemarie , Stol Kim , Vermont Clementien 
Published: May 2022

AbstractAlthough fatigue is a common symptom in adult patients with primary immunodeficiencies (PID), data in pediatric patients are limited. The goal of this study is to estimate the prevalence and impact of fatigue in children with PID as reported by patients, parents, and health-care providers. A retrospective single-center observational study was performed. Prevalence of fatigue was measured by reviewing medical charts of 54 children in our department who are on immunoglobulin replacement therapy. Both prevalence and impact were also measured by the PedsQL-Multidimensional Fatigue Scale (MFS) in 27 patients and 32 of their parents. This is an age-appropriate questionnaire for self-report of fatigue symptoms in patients aged 5–18 years and for parent proxy reports for patients aged 2–18 years. General, cognitive, and sleep-rest fatigue was measured, and a total fatigue score was calculated. Means, standard deviation and Z scores were calculated using age-specific reference values. Intraclass correlation coefficients (ICC) were calculated for comparison of scores provided by parents vs children’s self-reported scores. Both chart review data and PedsQL-MFS showed fatigue rates of 65%. Pediatric PID patients of all ages had significantly lower scores on all subscales and total score of the PedsQL-MFS compared to healthy children, indicating greater perceived symptoms of fatigue. General fatigue was the most affected subscale in PID patients, suggesting that fatigue in these patients is mainly physical. Seventy-four percent of PID patients had a Z score lower than − 1 on the general fatigue subscale indicating severe fatigue. Child-parent concordance varied between 0.24 and 0.93. Our results show the feasibility of the PedsQL-MFS survey to evaluate the prevalence and severity of fatigue in children with PID and underscore the importance of this issue in our patient care.
Physicochemical and Antioxidant Properties of White (Fiano cv) and Red (Negroamaro cv) Grape Pomace Skin Based Films
Authors: Gorrasi Giuliana , Viscusi Gianluca , Gerardi Carmela , Lamberti Elena , Giovinazzo Giovanna 
Published: May 2022

AbstractGrape pomace, as by-product of wine making, is a source of polyphenols, fibers, fatty acids, metals, and organic acids, which could be used as raw component for the production of sustainable materials. Novel biodegradable films based on pomaces, from Negroamaro (red) and Fiano (white), Italian grape cultivars, were fabricated. Physical, chemical and antioxidant properties of material produced were characterized. In particular, migration tests of phenols from pomace films to aqueous food simulant medium were investigated. Data obtained allowed to evaluate the antioxidant activity in terms of total phenol assay and Trolox Equivalent Antioxidant Capacity assay and phenols profile. The characterization of phenolic composition confirmed the peculiarity of some compounds such as anthocyanins (191.17 ± 10.3 μg/g film) in red skin pomace film (NPF) and a great amount of flavanols (76.36 ± 1.72 μg/g film) in white skin pomace film (FPF). Antioxidant activity of polyphenols resulted in active films and was confirmed in migration test with aqueous food simulants. Physical properties of produced films were then studied in terms of morphological, thermal, mechanical and barrier properties. Finally, in the framework of sustainability and circular economy, the presented data paves the way to the design and production of active materials for packaging application starting from a widely available by-product derived from wine-making chain.
Developing a knowledge ecosystem for large-scale research infrastructure
Authors: Rådberg Kamilla Kohn , Löfsten Hans 
Published: May 2022

AbstractLarge-scale research infrastructures (RIs), such as MAX IV and European Spallation Source in Lund, Sweden, are considered critical for advancing science and addressing social challenges. These research facilities are central to research, innovation, and education; in playing a key role in developing and disseminating knowledge and technology. In this study, we develop a conceptual framework of a knowledge ecosystem for large-scale RIs. The study is explorative, with primary data from 13 interviews with key informants from different stakeholders in academia, industry, and policy. Secondary data were obtained from reports from national agencies that develop and operate research facilities and from industrial and regional governmental reports, internal reports, newsletters, and information from the facilities’ websites. We find that academia, industry, and policy, together with four themes, have an effect on the value proposition of these facilities, on geographical distances (nodes), catalysts, platforms, and hubs. Therefore, they will affect the structure and design of a knowledge ecosystem. Our framework explains knowledge ecosystem structure and design.
Recent progress in drug development for fibrodysplasia ossificans progressiva
Authors: Meng Xinmiao , Wang Haotian , Hao Jijun 
Published: May 2022

AbstractFibrodysplasia Ossificans Progressiva (FOP) is a rare genetic disease caused by heterozygous missense mutations in Activin A receptor type I which is also known as Activin-like kinase 2 (ALK2), a type I receptor of Bone Morphogenetic Proteins(BMP). Patients with FOP usually undergo episodic flare-ups and the heterotopic ossification in soft and connective tissues. Molecular mechanism study indicates that Activin A, the ligand which normally transduces Transforming Growth Factor Beta signaling, abnormally activates BMP signaling through ALK2 mutants in FOP, leading to heterotopic bone formation. To date, effective therapies to FOP are unavailable. However, significant advances have recently been made in the development of FOP drugs. In this article, we review the recent advances in understanding the FOP mechanism and drug development, with a focus on the small-molecular and antibody drugs currently in the clinical trials for FOP treatment.
The Deception of Certainty: how Non-Interpretable Machine Learning Outcomes Challenge the Epistemic Authority of Physicians. A deliberative-relational Approach
Authors: Funer Florian 
Published: May 2022

AbstractDevelopments in Machine Learning (ML) have attracted attention in a wide range of healthcare fields to improve medical practice and the benefit of patients. Particularly, this should be achieved by providing more or less automated decision recommendations to the treating physician. However, some hopes placed in ML for healthcare seem to be disappointed, at least in part, by a lack of transparency or traceability. Skepticism exists primarily in the fact that the physician, as the person responsible for diagnosis, therapy, and care, has no or insufficient insight into how such recommendations are reached. The following paper aims to make understandable the specificity of the deliberative model of a physician-patient relationship that has been achieved over decades. By outlining the (social-)epistemic and inherently normative relationship between physicians and patients, I want to show how this relationship might be altered by non-traceable ML recommendations. With respect to some healthcare decisions, such changes in deliberative practice may create normatively far-reaching challenges. Therefore, in the future, a differentiation of decision-making situations in healthcare with respect to the necessary depth of insight into the process of outcome generation seems essential.
Adjustable robust treatment-length optimization in radiation therapy
Authors: ten Eikelder S. C. M. , Ajdari A. , Bortfeld T. , den Hertog D. 
Published: May 2022

AbstractTraditionally, optimization of radiation therapy (RT) treatment plans has been done before the initiation of RT course, using population-wide estimates for patients’ response to therapy. However, recent technological advancements have enabled monitoring individual patient response during the RT course, in the form of biomarkers. Although biomarker data remains subject to substantial uncertainties, information extracted from this data may allow the RT plan to be adapted in a biologically informative way. We present a mathematical framework that optimally adapts the treatment-length of an RT plan based on the acquired mid-treatment biomarker information, while accounting for the inexact nature of this information. We formulate the adaptive treatment-length optimization problem as a 2-stage problem, wherein the information about the model parameters gathered during the first stage influences the decisions in the second stage. Using Adjustable Robust Optimization (ARO) techniques we derive explicit optimal decision rules for the stage-2 decisions and solve the optimization problem. The problem allows for multiple worst-case optimal solutions. To discriminate between these, we introduce the concept of Pareto Adjustable Robustly Optimal solutions. In numerical experiments using lung cancer patient data, the ARO method is benchmarked against several other static and adaptive methods. In the case of exact biomarker information, there is sufficient space to adapt, and numerical results show that taking into account both robustness and adaptability is not necessary. In the case of inexact biomarker information, accounting for adaptability and inexactness of biomarker information is particularly beneficial when robustness (w.r.t. organ-at-risk (OAR) constraint violations) is of high importance. If minor OAR violations are allowed, a nominal folding horizon approach (NOM-FH) is a good performing alternative, which can outperform ARO. Both the difference in performance and the magnitude of OAR violations of NOM-FH are highly influenced by the biomarker information quality.
Spatiotemporal Distribution of Precipitates and Mineral Phase Transition During Biomineralization Affect Porosity–Permeability Relationships
Authors: Weinhardt Felix , Deng Jingxuan , Hommel Johannes , Vahid Dastjerdi Samaneh , Gerlach Robin , Steeb Holger , Class Holger 
Published: May 2022

AbstractEnzymatically induced calcium carbonate precipitation is a promising geotechnique with the potential, for example, to seal leakage pathways in the subsurface or to stabilize soils. Precipitation of calcium carbonate in a porous medium reduces the porosity and, consequently, the permeability. With pseudo-2D microfluidic experiments, including pressure monitoring and, for visualization, optical microscopy and X-ray computed tomography, pore-space alterations were reliably related to corresponding hydraulic responses. The study comprises six experiments with two different pore structures, a simple, quasi-1D structure, and a 2D structure. Using a continuous injection strategy with either constant or step-wise reduced flow rates, we identified key mechanisms that significantly influence the relationship between porosity and permeability. In the quasi-1D structure, the location of precipitates is more relevant to the hydraulic response (pressure gradients) than the overall porosity change. In the quasi-2D structure, this is different, because flow can bypass locally clogged regions, thus leading to steadier porosity–permeability relationships. Moreover, in quasi-2D systems, during continuous injection, preferential flow paths can evolve and remain open. Classical porosity–permeability power-law relationships with constant exponents cannot adequately describe this phenomenon. We furthermore observed coexistence and transformation of different polymorphs of calcium carbonate, namely amorphous calcium carbonate, vaterite, and calcite and discuss their influence on the observed development of preferential flow paths. This has so far not been accounted for in the state-of-the-art approaches for porosity–permeability relationships during calcium carbonate precipitation in porous media.
Derjaguin and the DMT Theory: A Farewell to DMT?
Authors: Greenwood J. A. 
Published: May 2022

AbstractThere is a widespread belief that in the 1970s, two conflicting theories of the adhesion of a spherical particle to a substrate were published: the JKR and DMT theories. And that the dispute was resolved when Tabor introduced a parameter $$\mu$$
μ
, such that for small $$\mu$$
μ
, DMT was correct, while for large $$\mu$$
μ
, JKR was correct. We point out that there never were two theories of contact: the dispute was about the magnitude of the pull-off force (with an implication that since the DMT value was obtained by a thermodynamic method, it must be correct). And what Tabor actually said was simply that for large $$\mu$$
μ
, the neglect of surface forces in the JKR theory was acceptable, and that he distrusted the neglect of deformation by the large surface forces immediately outside the Hertzian contact in the DMT theory. We point out the errors in both the DMT/MDT thermodynamic method and the MDT force method (preferred by MDT) but also argue that once Derjaguin and his collaborators (MYD) established that Hertzian geometry does not occur, no theory based on that geometry should be taken seriously. Derjaguin’s well-merited fame rests on more important contributions.
Bayesian Inversion with Open-Source Codes for Various One-Dimensional Model Problems in Computational Mechanics
Authors: Noii Nima , Khodadadian Amirreza , Ulloa Jacinto , Aldakheel Fadi , Wick Thomas , François Stijn , Wriggers Peter 
Published: May 2022

AbstractThe complexity of many problems in computational mechanics calls for reliable programming codes and accurate simulation systems. Typically, simulation responses strongly depend on material and model parameters, where one distinguishes between backward and forward models. Providing reliable information for the material/model parameters, enables us to calibrate the forward model (e.g., a system of PDEs). Markov chain Monte Carlo methods are efficient computational techniques to estimate the posterior density of the parameters. In the present study, we employ Bayesian inversion for several mechanical problems and study its applicability to enhance the model accuracy. Seven different boundary value problems in coupled multi-field (and multi-physics) systems are presented. To provide a comprehensive study, both rate-dependent and rate-independent equations are considered. Moreover, open source codes (https://doi.org/10.5281/zenodo.6451942) are provided, constituting a convenient platform for future developments for, e.g., multi-field coupled problems. The developed package is written in MATLAB and provides useful information about mechanical model problems and the backward Bayesian inversion setting.