bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Diversity-Aware Memetic Algorithm for the Linear Ordering Problem: Improving Best-Known Solutions for Standard Benchmarks
Authors: Lugo Lázaro , Segura Carlos , Miranda Gara 
Published: January 2022

Abstract

The Linear Ordering Problem (LOP) is a very popular NP-hard combinatorial optimization problem with many practical applications that may require the use of large instances. The Linear Ordering Library (LOLIB) gathers a set of standard benchmarks widely used in the validation of solvers for the LOP. Among them, the xLOLIB2 collects some of the largest and most challenging instances in current literature. In this work, we present new best-known solutions for each of the 200 complex instances that comprises xLOLIB2. Moreover, the proposal devised in this research is able to achieve all current best-known solutions in the rest of instances of LOLIB and improve them in other 93 cases out of 485, meaning that important advances in terms of quality and robustness are attained. This important advance in the field of the LOP has been possible thanks to the development of a novel Memetic Algorithm (MA) that was designed by taking into account some of the weaknesses of state-of-the-art LOP solvers. One of the keys to success is that the novel proposal allows for a gradual shift from exploration to exploitation, which is done by taking into account the stopping criterion and elapsed period of execution to alter the internal decisions taken by the optimizer. The novel diversity-aware proposal is called the Memetic Algorithm with Explicit Diversity Management (MA-EDM) and extensive comparisons against state-of-the-art techniques provide insights into the reasons for the superiority of MA-EDM.
Slug and Vimentin Downregulation at the Metastatic Site Is Associated With Skip-N2 Metastasis of Lung Adenocarcinoma
Authors: SAYGIDEGER Yasemin , AVCI Alper , BAGIR Emine , DEMİR Burcu SAYGIDEĞER , Ms Aycan SEZAN , EKICI Mucahit , BAYDAR Oya , ERKIN Ozgur Cem 
Published: January 2022

Abstract
Objective: Lung cancer displays heterogeneity both in the tumor itself and in its metastatic regions. One interesting behavior of the tumor is known as Skip N2 metastasis, which N2 lymph nodes contain tumor cells while N1 are clean. In this study, mRNA levels of epithelial mesenchymal transition (EMT) related genes in skip N2 and normal N2 involvements of non-small cell lung cancer tissues were investigated to evaluate the possible molecular background that may contribute to the pathogenesis of Skip N2 metastasis. Materials and Methods: Eighty-three surgically resected and paraffin embedded lymph node samples of lung cancer patients were analyzed in this study, which 40 of them were Skip N2. N2 tissues were sampled from 50% tumor containing areas and total RNA was extracted. mRNA levels for 18S, E-cadherin, Vimentin, ZEB1 and SLUG were analyzed via qPCR and E-cadherin and vimentin protein levels via immunohistochemistry (IHC). Bioinformatic analysis were adopted using online datasets to evaluate significantly co-expressed genes with SLUG in lung cancer tissue samples.Results: Skip-N2 patients who had adenocarcinoma subtype had better survival rates. Comparative analysis of PCR results indicated that Skip N2 tumor tissues had increased E-Cadherin/Vimentin ratio and ZEB1 mRNA expression, and significantly decreased levels of SLUG. E-cadherin IHC staining were higher in Skip N2 and Vimentin were in Non-Skip N2. TP63 had a strong correlation with SLUG expression in the bioinformatics analyses.Conclusion: The results indicate that, at molecular level, Skip N2 pathogenesis has different molecular background and regulation of SLUG expression may orchestrate the process.
Measured distribution of cloud chamber tracks from radioactive decay: a new empirical approach to investigating the quantum measurement problem
Authors: Schonfeld Jonathan 
Published: January 2022

Abstract
Using publicly available video of a diffusion cloud chamber with a very smallradioactive source, I measure the spatial distribution of where tracks start, and consider possibleimplications. This is directly relevant to the quantum measurement problem and its possibleresolution, and appears never to have been done before. The raw data are relatively uncontrolled,leading to caveats that should guide future, more tailored experiments. Results may suggest amodification to Born’s rule at very small wavefunction, with possibly profound implications forthe detection of extremely rare events such as proton decay. I introduce two candidate smallwavefunctionBorn rule modifications, a hard cutoff and an offset model; the data may favor theoffset model, which has a stronger underlying physical rationale. Track distributions from decaysin cloud chambers represent a previously unappreciated way to probe the foundations of quantummechanics, and a novel case of wavefunctions with macroscopic signatures.
Discrete Approximate Solution of Differential Inclusion with Normal Cone and Prox-Regular Set.
Authors: Beddani Abdallah , Sahraoui Rahma 
Published: January 2022

Abstract
Our aim is to calculate the discrete approximate solution of di⁄erential inclusion with normal cone and prox-regular set, the question is how to calculate this solution? We use the discrete approximation property of a new variant of nonconvex sweeping processes involving normal cone and a nite element method. Knowing that The majority of mathematicians have proved only the existence and uniqueness of the solution for this type of inclusions, like: Mordukhovich, Thibault, Aubin, Messaoud, ...etc.
Use of Dexmedetomidine in a Patient Allergic to Clonidine Presenting for an Awake Craniotomy: A Case Report
Authors: Srita Yasmin , Cornell Brett , Maggard Brittany 
Published: January 2022

Abstract
Introduction: The use of dexmedetomidine with concurrent scalp block is increasingly being utilized as an effective and safe anesthetic approach for awake craniotomy (AC). Dexmedetomidine is an alpha-2 adrenergic receptor (α2-AR) agonist with dose-dependent sedative, analgesic, and anxiolytic properties while preserving respiratory function. The challenge with the use of dexmedetomidine arises when the patient in question has a clonidine allergy that is also an α2-AR agonist. Currently there aren’t any published literature regarding the use of dexmedetomidine in a patient allergic to clonidine. Case Presentation: A 48-year-old male with chronic obstructive pulmonary disease, obstructive sleep apnea, and body mass index of 54 with clonidine allergy presents for an AC. Given the goals of the surgery and patient comorbidities, we planned for monitored anesthesia care with intravenous (IV) dexmedetomidine, remifentanil, and propofol. We discussed the use of dexmedetomidine with the patient and the potential risk of allergic reaction given his allergy to clonidine. Patient understood the risk and consented to the anesthetic plan. AC was successfully performed with IV dexmedetomidine, remifentanil, and propofol.Conclusion: Although both dexmedetomidine and clonidine have some functional similarities in terms of acting on the central and peripheral nervous system, there are marked differences between the two based on chemical structure, receptor affinity, and metabolism of the drug. This case highlights the successful use of dexmedetomidine in a patient with known allergy of rash to clonidine.
Engineering and Fermenter Optimization of Fungi GLA Productions in Pichia Pastoris GS115 Using Oil Waste
Authors: Firoozabad Maryam Sadat Mirbagheri , Akhbariyoon Hamidreza 
Published: January 2022

Abstract
γ-Linolenic acid (GLA) is an important n-6 polyunsaturated fatty acid (PUFA) that has received considerable attention in both levels in human and animal feed. GLA is used in many nutritional and medicinal applications such as the treatment of cancer, inflammatory disorders, and diabetes. Currently, plant seed is the main dietary source of GLA that is not enough to utilize on an industrial scale. To generate a sustainable novel source of GLA, the gene of delta-6 desaturase, which is one of the important enzymes in the GLA production pathway was isolated from Mucor rouxii DSM1194 and expressed in Pichia pastoris GS115 by pPICZC vector. The recombinant yeast expressed the GLA up to 19.2% (72 mg/g) of total fatty acids. GLA production of recombinant yeast was studied in fermenter by oil waste along 5 days and results detected 6.3 g / l lipid and 103 mg/g GLA was produced in 72 hours. The present study may provide an opportunity for the development of an alternative host for manufacturing GLA on an industrial scale.
LITERASI DIGITAL DALAM PENGUATAN STUDI KEISLAMAN MAHASISWA FTIK IAIN TULUNGAGUNG
Authors: Suwanto Suwanto 
Published: January 2022

Mahasiswa memiliki intensitas tinggi dalam mengakses internet. Sedangkan pemanfaatan dibidang pendidikan baru 55,30%. Pada sisi lain pada laman sinta2.ristekdikti.go.id terdapat artikel yang berkaitan dengan studi keislaman. Sehingga kajian studi keislaman perlu merespon baik hal tersebut. Penelitian yang dilakukan bertujuan 1) mengetahui strategi dosen membangun kompetensi berliterasi E-Jurnal mahasiswa FTIK IAIN Tulunggung, 2) mengetahui kompetensi berliterasi dengan E-Jurnal mahasiswa FTIK IAIN Tulunggung, dan 3) mengetahui pemanfaatan E-jurnal dalam studi keislaman mahasiswa FTIK IAIN Tulungagung. Penelitian ini menggunakan penelitian kualitatif dengan pendekatan studi kasus. Penentuan narasumber menggunakan teknik purposive sampling. Sumber data berasal dari dosen, mahasiswa, dan pengelola program studi. Pengumpulan data menggunakan teknik observasi partisipatif, wawancara mendalam dan dokumentasi. Analisis data menggunakan teorinya Miles dan Huberman dengan 4 tahapan. Sedangkan uji keabsahan data dengan perpanjangan kehadiran peneliti di tempat penelitian, melakukan pengamatan terus menerus dan trianggulasi. Hasil dari penelitian ini 1) Dosen telah melakukan strategi membangun kompetensi berliterasi E-Jurnal mahasiswa FTIK IAIN Tulunggung. Sudah menunjukkan adanya sasaran yang terpenting yang akan dicapai, ada kebijakan-kebijakan yang mengarah kepada pelaksanaan dan langkah-langkah yang mewujudkan sasaran tersebut, 2) Mahasiswa telah memiliki kompetensi berliterasi E-jurnal sebab mereka baru dapat melakukan searching bebas dan dapat memahami arah hipertex tetapi belum mampu melakukan content evaluation dan knowledge Assembly, 3) Sudah ada pemanfaatan E-jurnal dalam studi keislaman mahasiswa FTIK IAIN Tulungagung Referensi yang digunakan tidak hanya buku dan dan jurnal cetak.
Technology and Theory of Mechanically Activated Water in Bakery Industry
Authors: Rudnev Sergey , Shevchenko Tatyana , Ustinova Yulia , Kryuk Roman , Ivanov Viktor , Chistyakov Andrey 
Published: January 2022

Introduction. Bakery products are an important part of traditional Russian menu. Activated water helps to improve the quality of flour products. The present research objective was (1) to activate water with mechanical energy to change the physicochemical properties of the dough; (2) to evaluate the energy efficiency of the new technological process, and (3) to determine the quality indicators of bread.
Study objects and methods. The research featured high quality wheat flour, drinking water, and pressed baking yeast (Saccharomyces cerevisiae). Standard research methods were used to assess the physical and chemical properties of water, namely acidity index (pH), surface tension coefficient, and biological activity. The physico-chemical properties of the dough were studied by maximum shear stress and adhesion.
Results and discussion. The samples of activated water demonstrated the following technological properties. Its acidity due decreased as pH fell down to 6.05. With a total mixing time of 10 min, the surface tension decreased by about 10%; after 5 min, it decreased by 4%, while the biological activity of activated water increased by 1.5 times. Mechanically treated water used for bread production contributed to the overall energy saving during kneading and increased its water-binding ability. Moisture removal was by 30–40% more intensive than in the control dough sample. Also, the quality of gluten changed as a result of higher shear stress, which gave the experimental dough better forming properties necessary for the production of high-quality bread. The mechanically activated water increased the specific volume of bread from 2.05 to 2.38 cm3/g.
Conclusion. The activated water improved the physico-chemical and rheological properties of dough, as well as the main sensory indicators of bread, e.g. porosity and bread crumb elasticity.
Effect of Berry Extracts on Saccharomyces cerevisiae Yeast
Authors: Kuzmina Svetlana , Kozubaeva Lyudmila , Egorova Elena , Kulushtayeva Botakoz , Smolnikova Farida 
Published: January 2022

Introduction. Fruit and berry extracts contain biologically active components and acids that can inhibit or activate Saccharomyces cerevisiae. The research objective was to study the effect of berry extracts on the activity of baking yeast S. cerevisiae and the biochemical properties of wheat dough.
Study objects and methods. The experiment featured baking yeast Extra and dry berry extracts of raspberries, aronia, sea buckthorn, and rosehip (LLC Wisterra, Altai Region). The study involved standard and industry-specific control methods of raw materials and semi-finished bakery products, as well as som e standard methods of microbiological analysis.
Results and discussion. The raspberry extract (3–4%) suppressed the growth and reproduction of the yeast: after 1 h of exposure, the yeast cell count dropped by 1.5–2 times compared to the control sample. The stimulating effect of the sea buckthorn extract increased the growth rate of yeast cells (up to 40% compared to the control). The extracts of aronia and rosehip had practically no effect on the growth rate of yeast cells. However, 2–3% aronia extract increased the fermentation of the dough, as evidenced by a higher dough fermentation property, which was 2 min versus 3 min at the control after 150 min of exposure. Fruit and berry extracts caused a natural increase in the acidity of the dough, which affected the growth rate of yeast cells. Sea buckthorn extracts increased the acidity so much (up to 4.24 pH units) that it could be regarded as acid stress, which increased the growth rate of yeast cells (1.53×106–1.55×106 vs. 1.10×106 in 1 mL of control sample). The lowest growth rate was detected in the samples with the raspberry extract, which is known to have a strong fungistatic effect: the count of yeast cells decreased by 1.5–2 times after an hour of fermentation.
Conclusion. Berry extracts can be of practical interest to bakery enterprises as they help to control yeast fermentation and dough maturation time.
Contemporary Biological Methods of Mine Reclamation in the Kemerovo Region – Kuzbass
Authors: Fotina Natalya , Emelianenko Vladislav , Vorob’eva Ekaterina , Burova Nadezhda , Ostapova Elena 
Published: January 2022

Introduction. Coal mining is the main source of anthropogenic impact on the landscapes of the Kemerovo Region – Kuzbass. The current mine reclamation rate lags far behind the annual increase in disturbed lands. A reclamation fund can be a perfect solution to this relevant issue. The present research objective was to analyze and structure the available data on the anthropogenic impact of coal mining in Kuzbass. The article reviews new effic ient methods of reclamation and resoiling.
Study objects and methods. The study featured ten years of research publications that were registered in the PubMed database of the National Center for Biotechnology Information (USA), Elsevier (Scopus, ScienceDirect), the Web of Science, and the Russian Electronic Library (eLibrary.ru).
Results and discussion. The research revealed the following Kuzbass districts that experience the greatest mining impact: Novokuznetsk, Prokopyevsk, Kemerovo, Belovo, and Leninsk-Kuznetskiy. The authors also identified the most common pollutants associated with coal mining. Polycyclic aromatic hydrocarbons (PAHs) appeared to be the most dangerous pollutants: as waste coal burns, these substances cover considerable distances with the wind. Biodegradation seems to be the optimal solution because PAHs are known to be carcinogenic, and most mine tips are located near settlements. The article also features mine reclamation laws and introduces a list of plants with a high absorption capacity recommended for biological reclamation, as well as microorganisms and their consortia used for bioremediation.
Conclusion. The authors identified the most promising methods of mine reclamation in the Kemerovo region, i.e. bioremediation with pollutant-binding microbial consortia and plants.
Prospects of Using Soil Microbiome of Mine Tips for Remediation of Anthropogenically Disturbed Ecosystems
Authors: Faskhutdinova Elizaveta , Osintseva Maria , Neverova Olga 
Published: January 2022

Introduction. Coal industry increases soil pollution with heavy metals and polycyclic aromatic hydrocarbons. Therefore, resoiling is an urgent problem that requires an immediate solution. The present research objective was to substantiate the use of microorganisms from mine tips in order to decrease soil pollution with heavy metals and oil compounds.
Study objects and methods. The review featured five years of publications in Scopus, Web of Science, and Elibrary, which were subjected to analysis, systematization, and generalization.
Results and discussion. Coal industry changes landscapes, flora, fauna, and soil microbiome. Bioremediation uses various microorganisms as means of resoiling. Some microorganisms isolated from coal mining waste are resistant to heavy metals and polycyclic aromatic hydrocarbons and are able to utilize them. For instance, such bacteria as Bacillus and Pseudomonas aeruginosa are capable of degrading oil pollutants. Microorganisms of Enterobacter and Klebsiella species were found to be resistant to copper, iron, lead, and manganese. Bacteria of the genera Bacillus, Arthrobacter, Pseudoarthrobacter, and Sinomonas are now to be resistant to nickel, arsenic, and chromium. Arbuscular mycorrhizal fungi increase the activity of soil enzymes, improve soil fertility, and decompose various organic compounds.
Conclusion. Sequencing methods make it possible to determine the species composition of soils in mine tips in order to search for new strains capable of restoring former mining areas.
Review on Natural Bioactive Products as Radioprotective Therapeutics: Present and Past Perspective
Authors: Bhandari Meena , Raj Seema , Manchanda Romila , Alam Md. Sabir 
Published: January 2022

Abstract:Among conventional treatment methodologies, surgery, hyperthermia, radiation, and chemotherapy have become integral components of treatment for most cancers. Radiation therapy in the treatment of many malignancies is always the better choice over surgery and chemotherapy. Ionizing radiation produced as a consequence of using these radiations has always been a concern in these treatment methods. Synthetic radio-protectors with their inherent limitations are being used to date to reduce the mortality of these radiations; still, it compromises the clinical efficacy of these administrations. Hence, investigations for alternative methods, including natural resources such as plant and fruit extracts, are being explored to treat radiation-mediated ailments. The present review article endeavors to provide a comprehensive, updated, and chronological account of these promising plants and fruit extracts and their bioactive principles as radio-protectors. We present the merits and demerits of radiation therapy and cell stress generation of reactive oxygen species (ROS) associated with radiation need and availability of radio-protectors. Finally, we discuss green-based bioactive compounds that have radioprotective properties.
Synthesis and Antimicrobial Activity of Functional Derivatives of thiazolo[ 2,3-c][1,2,4]triazoles
Authors: Slivka Mikhailo , Fizer Maksym , Mariychuk Ruslan , Ostafin Marek , Moyzesh Olexander , Koval Galyna , Holovko-Kamoshenkova Oksana , Rusyn Ivan , Lendel Vasyl 
Published: January 2022

Background:Condensed triazoles are a well-known class of heterocyclic compounds due to a wide range of biological activities. The study is dedicated to the evaluation of the antimicrobial potential of new functional derivatives of thiazolo[2,3-c][1,2,4]triazoles.Methods:Effective, easy-to-implement and low-cost routes for production of title compounds via electrophilic intramolecular heterocyclization are reported. Bactericidal and fungicidal activities against Gram-positive and Gram-negative bacteria and fungus were studied. The influence of functional groups on the biological activity of tested thiazolo[2,3-c][1,2,4]triazoles is discussed.Results:Microbiological evaluation shows that 6-[(trichlorotellanyl)methyl]-[1,3]thiazolo[2,3- c][1,2,4]triazol-3-amine hydrogen chloride 2a and 3-(2-hydroxyphenyl)-6-[(trichloro-λ4-tellanyl)methyl]- 5,6-dihydro-[1,3]thiazolo[2,3-c][1,2,4]triazole 2g have a high bactericidal activity and Cu (I) salts of 3-(2- hydroxyphenyl)-6-iodomethyl/6-methylidene-5,6-dihydro-[1,3]thiazolo-[2,3-c][1,2,4]triazoles 5a,c have a high fungicidal activity.Conclusion:It is concluded that these products or their derivatives may be of practical benefit as bactericidal and fungicidal agents.
Review on Synthesis of (S)-5-Benzylpyrrolidine-2,4-dione Derivatives with
Substitution at C-3 Position by Employing Functional Groups Interconversion
Authors: Pungot Noor Hidayah , Zulkifli Munirah , Abdullah Noraishah , Ash’ari Nur Ain Nabilah , Shaameri Zurina 
Published: January 2022

Abstract:
5-benzylpyrrolidine-2,4-dione 9 are versatile scaffolds with a unique structural feature responsible
for the diversity of its biological importance. Over the past years, many researchers have
reported the synthesis of various bio-active (S)-5-benzylpyrrolidine-2,4-dione derivatives due to their
simplicity yet exhibiting promising bioactivities. This review focuses on the synthesis of core structure
9 and its derivatives based on the substitution at carbon-3 position of (S)-5-benzylpyrrolidine-
2,4-dione 9. This review also reported the effective method for the synthesis of core structure 9 with a
98% yield. Biological evaluations of various prepared derivatives by various researchers were described.
Natural Products from Octocorals of the Genus Verrucella (Milne Edwards
& Haime, 1857)
Authors: Liaw Chia-Ching , Sung Ping-Jyun , Wu Yu-Jen , Neoh Choo-Aun , Tsai Yu-Chi , Lo Yi-Hao , Wu Yang-Chang , Wen Zhi-Hong 
Published: January 2022

Abstract:
In this review, we summarize the diverse marine natural compounds obtained from the genus Verrucella and their pharmacological effects and present a survey of the natural products taxonomy according to species. Sixty-six natural substances, including fifty-three steroids, six briarane-type diterpenoids, five nitrogenous bases, one amide, and one glycerol derivative, were obtained from Verrucella spp., which were mainly collected from the South China Sea and the Bay of Bengal, India. Steroids were the major constituents found in Verrucella spp. Moreover, anticancer, antimicrobial, and immunomodulatory activities of those steroids and other compounds are also presented. This review reveals the chemical diversity, chemotaxonomy, and multiple pharmacological effects of the Verrucella genus. It will be helpful for further research and exploration of new steroid analogs and other components with prospective biological activities from this marine organism.