bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and associated factors of neonatal mortality in Ethiopia
Authors: Alamirew Walelgn Gete , Belay Denekew Bitew , Zeru Melkamu A. , Derebe Muluwerk Ayele , Adegeh Senait Cherie 
Published: July 2022

AbstractNeonatal mortality is the death of a live-born baby within the first 28 days of birth. For the selected households, neonatal mortality was collected from children aged 0–28 days and women aged 15–49. The neonatal period is a significant 4-week period in human life because it carries a greater mortality risk. To identify the determinant factors of neonatal mortality in Ethiopia based on EDHS 2016 data with the application of count regression models. In this study, all neonates in Ethiopia were born within the 5 years preceding EDHS 2016 of the source population in the selected EAs from September to December 2015. Count regression models were used to analyze the data. A total of 10,641 live-born neonates within the previous 5 years of EDHS 2016 had neonatal mortality of women aged 15–49, which was considered in the study to be 7193. The data were found to have excess zeros (96.6%), and the variance (0.052) was higher than its mean (0.04). The count regression model (ZINB) was best fitted to the data with maximum likelihood parameter estimation methods. The average neonatal mortality difference in multiple births was increased by IRR = 8.53 times compared with a single birth. The average number of neonatal deaths experienced during breastfeeding was lower (IRR = 0.38) than that experienced by mothers who did not experience breastfeeding their child. The average neonatal mortality difference in rural residences was increased by IRR = 3.99 times compared to urban mothers' residences. In this study, the prevalence of Neonatal mortality in Ethiopia was higher. For selected ZINB count regression models of explanatory variables, such as multiple birth types, having rural residence factors of neonatal mortality increased the risk of death. However, having early breastfeeding, a female household head, and antenatal visits (1–4) and (5–10) during pregnancy decrease the risk of neonatal death.
A Mach-Zehnder Fabry-Perot hybrid fiber-optic interferometer operating at the thermal noise limit
Authors: Hoque Nabil Md Rakinul , Duan Lingze 
Published: July 2022

AbstractA new type of interferometric fiber sensor based on a Mach-Zehnder Fabry-Perot hybrid scheme has been experimentally demonstrated. The interferometer combines the benefits of both a double-path configuration and an optical resonator, leading to record-high strain and phase resolutions limited only by the intrinsic thermal noise in optical fibers across a broad frequency range. Using only off-the-shelf components, the sensor is able to achieve noise-limited strain resolutions of 40 f$$\varepsilon $$
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at 10 Hz and 1 f$$\varepsilon $$
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at 100 kHz. With a proper scale-up, atto-strain resolutions are believed to be within reach in the ultrasonic frequency range with such interferometers.
Repeated ketamine anesthesia during neurodevelopment upregulates hippocampal activity and enhances drug reward in male mice
Authors: Cui Jianchen , Ju Xianshu , Lee Yulim , Hong Boohwi , Kang Hyojin , Han Kihoon , Shin Won-Ho , Park Jiho , Lee Min Joung , Kim Yoon Hee , Ko Youngkwon , Heo Jun Young , Chung Woosuk 
Published: July 2022

AbstractEarly exposures to anesthetics can cause long-lasting changes in excitatory/inhibitory synaptic transmission (E/I imbalance), an important mechanism for neurodevelopmental disorders. Since E/I imbalance is also involved with addiction, we further investigated possible changes in addiction-related behaviors after multiple ketamine anesthesia in late postnatal mice. Postnatal day (PND) 16 mice received multiple ketamine anesthesia (35 mg kg−1, 5 days), and behavioral changes were evaluated at PND28 and PND56. Although mice exposed to early anesthesia displayed normal behavioral sensitization, we found significant increases in conditioned place preference to both low-dose ketamine (20 mg kg−1) and nicotine (0.5 mg kg−1). By performing transcriptome analysis and whole-cell recordings in the hippocampus, a brain region involved with CPP, we also discovered enhanced neuronal excitability and E/I imbalance in CA1 pyramidal neurons. Interestingly, these changes were not found in female mice. Our results suggest that repeated ketamine anesthesia during neurodevelopment may influence drug reward behavior later in life.
Insulating materials for realising carbon neutrality: Opportunities, remaining issues and challenges
Authors: Li Chuanyang , Yang Yang , Xu Guoqiang , Zhou Yao , Jia Mengshuo , Zhong Shaolong , Gao Yu , Park Chanyeop , Liu Qiang , Wang Yalin , Akram Shakeel , Zeng Xiaoliang , Li Yi , Liang Fangwei , Cui Bin , Fang Junpeng , Tang Lingling , Zeng Yulin , Hu Xingtao , Gao Jiachen , Mazzanti Giovanni , He Jinliang , Wang Jianxiao , Fabiani Davide , Teyssedre Gilbert , Cao Yang , Wang Feipeng , Zi Yunlong 
Published: July 2022

AbstractThe 2050 carbon‐neutral vision spawns a novel energy structure revolution, and the construction of the future energy structure is based on equipment innovation. Insulating material, as the core of electrical power equipment and electrified transportation asset, faces unprecedented challenges and opportunities. The goal of carbon neutral and the urgent need for innovation in electric power equipment and electrification assets are first discussed. The engineering challenges constrained by the insulation system in future electric power equipment/devices and electrified transportation assets are investigated. Insulating materials, including intelligent insulating material, high thermal conductivity insulating material, high energy storage density insulating material, extreme environment resistant insulating material, and environmental‐friendly insulating material, are categorised with their scientific issues, opportunities and challenges under the goal of carbon neutrality being discussed. In the context of carbon neutrality, not only improves the understanding of the insulation problems from a macro level, that is, electrical power equipment and electrified transportation asset, but also offers opportunities, remaining issues and challenges from the insulating material level. It is hoped that this paper envisions the challenges regarding design and reliability of insulations in electrical equipment and electric vehicles in the context of policies towards carbon neutrality rules. The authors also hope that this paper can be helpful in future development and research of novel insulating materials, which promote the realisation of the carbon‐neutral vision.
Transoral incisionless fundoplication is cost-effective for treatment of gastroesophageal reflux disease
Authors: McCarty Thomas R. , Jirapinyo Pichamol , James Lyndon P. , Gupta Sanchit , Chan Walter W. , Thompson Christopher C. 
Published: July 2022

Abstract
Background and study aims Given the sizable number of patients with symptomatic gastroesophageal reflux disease (GERD) despite proton pump inhibitor (PPI) therapy, non-pharmacologic treatment has become increasingly utilized. The aim of this study was to analyze the cost-effectiveness of medical, endoscopic, and surgical treatment of GERD.
Patients and methods A deterministic Markov cohort model was constructed from the US healthcare payer’s perspective to evaluate the cost-effectiveness of three competing strategies: 1) omeprazole 20 mg twice daily; 2) transoral incisionless fundoplication (TIF 2.0); and 3) laparoscopic Nissen fundoplication [LNF]. Cost was reported in US dollars with health outcomes recorded in quality-adjusted life years (QALYs). Ten-year and lifetime time horizons were utilized with 3 % discount rate and half-cycle corrections applied. The main outcome was incremental cost-effectiveness ratio (ICER) with a willingness-to-pay threshold of $ 100,000 per QALY. Probabilistic sensitivity analyses were also performed.
Results In our base-case analysis, the average cost of TIF 2.0 was $ 13,978.63 versus $ 17,658.47 for LNF and $ 10,931.49 for PPI. Compared to the PPI strategy, TIF 2.0 was cost-effective with an incremental cost of $ 3,047 and incremental effectiveness of 0.29 QALYs, resulting in an ICER of $ 10,423.17 /QALY gained. LNF was strongly dominated by TIF 2.0. Over a lifetime horizon, TIF 2.0 remained the cost-effective strategy for patients with symptoms despite twice-daily 20-mg omeprazole. TIF 2.0 remained cost-effective after varying parameter inputs in deterministic and probabilistic sensitivity analyses and for scenario analyses in multiple age groups.
Conclusions Based upon this study, TIF 2.0 was cost-effective for patients with symptomatic GERD despite low-dose, twice-daily PPI.
Early prediction of post-ERCP pancreatitis by post-procedure amylase and lipase levels: A systematic review and meta-analysis
Authors: Goyal Hemant , Sachdeva Sonali , Sherazi Syed Ali Amir , Gupta Shweta , Perisetti Abhilash , Ali Aman , Chandan Saurabh , Tharian Benjamin , Sharma Neil , Thosani Nirav 
Published: July 2022

Abstract
Background and study aims Post-ERCP pancreatitis (PEP) is the most common complication attributed to the procedure, its incidence being approximately 9.7 %. Numerous studies have evaluated the predictive efficacy of post-procedure serum amylase and lipase levels but with varied procedure-to-test time intervals and cut-off values. The aim of this meta-analysis was to present pooled data from available studies to compare the predictive accuracies of serum amylase and lipase for PEP.
Patients and methods A total of 18 studies were identified after a comprehensive search of various databases until June 2021 that reported the use of pancreatic enzymes for PEP.
Results The sample size consisted of 11,790 ERCPs, of which PEP occurred in 764 (6.48 %). Subgroups for serum lipase and amylase were created based on the cut-off used for diagnosing PEP, and meta-analysis was done for each subgroup. Results showed that serum lipase more than three to four times the upper limit of normal (ULN) performed within 2 to 4 hours of ERCP had the highest pooled sensitivity (92 %) for PEP. Amylase level more than five to six times the ULN was the most specific serum marker with a pooled specificity of 93 %.
Conclusions Our analysis indicates that a lipase level less than three times the ULN within 2 to 4 hours of ERCP can be used as a good predictor to rule out PEP when used as an adjunct to patient clinical presentation. Multicenter randomized controlled trials using lipase and amylase are warranted to further evaluate their PEP predictive accuracy, especially in high-risk patients.
Clinical application and diagnostic accuracy of artificial intelligence in colonoscopy for inflammatory bowel disease: systematic review
Authors: Yang Linda S. , Perry Evelyn , Shan Leonard , Wilding Helen , Connell William , Thompson Alexander J. , Taylor Andrew C. F. , Desmond Paul V. , Holt Bronte A. 
Published: July 2022

Abstract
Background and aims Artificial intelligence (AI) technology is being evaluated for its potential to improve colonoscopic assessment of inflammatory bowel disease (IBD), particularly with computer-aided image classifiers. This review evaluates the clinical application and diagnostic test accuracy (DTA) of AI algorithms in colonoscopy for IBD.
Methods A systematic review was performed on studies evaluating AI in colonoscopy of adult patients with IBD. MEDLINE, Embase, Emcare, PsycINFO, CINAHL, Cochrane Library and Clinicaltrials.gov databases were searched on 28th April 2021 for English language articles published between January 1, 2000 and April 28, 2021. Risk of bias and applicability were assessed with the Quality Assessment of Diagnostic Accuracy Studies-2 tool. Diagnostic accuracy was presented as median (interquartile range).
Results Of 1029 records screened, nine studies with 7813 patients were included for review. AI was used to predict endoscopic and histologic disease activity in ulcerative colitis, and differentiation of Crohn’s disease from Behcet’s disease and intestinal tuberculosis. DTA of AI algorithms ranged between 52–91 %. The sensitivity and specificity for AI algorithms predicting endoscopic severity of disease were 78 % (range 72–83, interquartile range 5.5) and 91 % (range 86–96, interquartile range 5), respectively.
Conclusions AI has been primarily used to assess disease activity in ulcerative colitis. The diagnostic performance is promising and suggests potential for other clinical application of AI in IBD colonoscopy such as dysplasia detection. However, current evidence is limited by retrospective data and models trained on still images only. Future prospective multicenter studies with full-motion videos are needed to replicate the real-world clinical setting.
Bowel preparation prior to colonoscopy with a new colonic irrigation device: Results of a prospective observational study
Authors: Teich Niels , Klecker Chris , Klugmann Tobias , Dietel Peter 
Published: July 2022

Abstract
Background and study aims The success of colonoscopy is mainly dependent on the effectiveness of prior bowel preparation (BP). Patients often consider BP to be the most burdensome part of colonoscopy, which might be a main barrier to the procedure. The aim of this study was to evaluate safety and effectiveness of colonic irrigation with a new colon hydrotherapy (CHT) device as an alternative to traditional oral BP.
Patients and methods A prospective, non-randomized observational study was conducted to evaluate the quality of BP. A BP was considered effective if a score of 6 or better through the Boston Bowel Preparation Scale (BBPS) could be reached. Colonoscopy was performed immediately following colonic irrigation. For safety analysis, data on adverse events (AEs) were collected. Among the secondary outcomes, the BBPS assessed in each bowel segment and cecal intubation rate were analyzed.
Results Twenty-eight consecutive patients (11 male [39.3%] and 17 [60.7 %] female) undergoing screening/surveillance or diagnostic colonoscopy were enrolled. Mean age was 54 ± 12.4 years (range 19–80). The evaluated mean BBPS was 7.8 ± 1.5. Twenty-five patients (89.3 %) had a BBPS score of 6 or above. Colonic irrigation was performed without any complications and no AEs were reported within 30 days. The cecal intubation rate was 100 %.
Conclusions Colonic irrigation with a new CHT device is an effective and low-risk alternative to traditional oral preparation prior to colonoscopy.
Investigating the Genetic Etiology of Pediatric Patients with Peripheral Hypotonia Using the Next-Generation Sequencing Method
Authors: Eker Damla , Gurkan Hakan , Karal Yasemin , Yalcintepe Sinem , Demir Selma , Atli Engin , Karasalihoglu Serap T. 
Published: July 2022

Abstract
Background Hypotonia occurs as a result of neurological dysfunction in the brain, brainstem, spinal cord, motor neurons, anterior horn cells, peripheral nerves, and muscles. Although the genotype–phenotype correlation can be established in 15 to 30% of patients, it is difficult to obtain a correlation in most cases.
Aims This study was aimed to investigate the genetic etiology in cases of peripheral hypotonia that could not be diagnosed using conventional methods.
Methods A total of 18 pediatric patients with peripheral hypotonia were included. They were referred to our genetic disorders diagnosis center from the Pediatric Neurology Department with a prediagnosis of hypotonia. A custom designed multigene panel, including ACTA1, CCDC78, DYNC1H1, GARS, RYR1, COL6A1, COL6A2, COL6A3, FKRP, FKTN, IGHMBP2, LMNA, LAMA2, LARGE1, MTM1, NEM, POMGnT1, POMT1, POMT2, and SEPN1, was used for genetic analysis using next-generation sequencing (NGS).
Results In our study, we found 13 variants including pathogenic (two variants in LAMA2) and likely pathogenic variants (three variants in RYR1 and POMGnT1) and variants of uncertain clinical significance (eight variants in RYR1, COL6A3, COL6A2, POMGnT1 and POMT1) in 11 (61%) out of 18 patients. In one of our patients, a homozygous, likely pathogenic c.1649G > A, p.(Ser550Asn) variant was defined in the POMGnT1 gene which was associated with a muscle–eye–brain disease phenotype.
Conclusion The contribution of an in-house designed gene panel in the etiology of peripheral hypotonia with a clinical diagnosis was 5.5%. An important contribution with the clinical diagnosis can be made using the targeted multigene panels in larger samples.
Severity of Pediatric COVID-19: Role of Vitamin D
Authors: Nassar May Fouad , Allam Mohamed Farouk , ElKhayat Samer Hamed , Darwish Yasser Wagih , Shata Mennatallah Osama 
Published: July 2022

Abstract
Objective Vitamin D has many immune benefits and because its deficiency impacts most age groups, it became a nutrient of interest in the coronavirus disease 2019 (COVID-19) era. The objective of this study was to highlight the contribution of vitamin D status to the disease severity of hospitalized pediatric patients suffering from COVID-19 infection.
Methods This was a cross-sectional study that was conducted on 42 children with documented positive polymerase chain reaction for COVID-19 infection. Detailed history taking and thorough clinical examination were done for each recruited patient. Besides the laboratory and radiological assessment done for COVID-19 patients, 25 hydroxy vitamin D levels [25(OH) D] in the serum were estimated using enzyme linked immunosorbent assay.
Results Using the cutoff level of 10 ng/mL, only 40% of the patients were below this level and 60% had their vitamin D level more than or equal to 10 ng/mL. Significantly more patients of the first group needed oxygen support (denoting more severe COVID-19 infection and lung involvement). The older the patients, the more evident was vitamin D deficiency among them, and 25(OH) D values were not correlated to weight for length nor weight categories in the studied series of patients suffering from COVID-19.
Conclusion Vitamin D deficiency affects the severity of pediatric COVID-19 infection in hospitalized patients. It is prudent to advise vitamin D level assessment in such cases and promptly manage the patients accordingly. We recommend further studies to assess the effect of vitamin D supplementation on the clinical outcome of COVID-19 in the pediatric population and other vulnerable groups.
Evolution of Surgical Outcomes in Endoscopic Endonasal Resection of Craniopharyngiomas
Authors: Yu Siyuan , Taghvaei Mohammad , Reyes Maikerly , Collopy Sarah , Piper Keenan , Karsy Michael , Prashant Giyarpuram N. , Kshettry Varun R. , Rosen Marc R. , Farrell Christopher J. , Evans James J. 
Published: July 2022

AbstractIntroduction Wide variations exist in the management of craniopharyngiomas, including pituitary stalk preservation/sacrifice. This study examines the practice patterns over 16 years using the endoscopic endonasal approach for the resection of craniopharyngiomas and it examines the effects of stalk preservation.Methods Retrospective analysis was conducted for 66 patients who underwent endoscopic transsphenoidal surgery for resection of craniopharyngiomas. Patients were stratified into three epochs: 2005 to 2009 (N = 20), 2010 to 2015 (N = 23), and 2016 to 2020 (N = 20), to examine the evolution of surgical outcomes. Subgroup analysis between stalk preservation/stalk sacrifice was conducted for rate of gross total resection, anterior pituitary function preservation, and development of new permanent diabetes insipidus.Results Gross total resection rates across the first, second, and third epochs were 20, 65, and 52%, respectively (p = 0.042). Stalk preservation across epochs were 100, 5.9, and 52.6% (p = 0.0001). New permanent diabetes insipidus did not significantly change across epochs (37.5, 68.4, 71.4%; p = 0.078). Preservation of normal endocrine function across epochs was 25, 0, and 23.8%; (p = 0.001). Postoperative cerebrospinal fluid (CSF) leaks significantly decreased over time (40, 4.5, and 0%; [p = 0.0001]). Stalk preservation group retained higher normal endocrine function (40.9 vs. 0%; p = 0.001) and less normal-preoperative to postoperative panhypopituitarism (18.4 vs. 56%; p = 0.001). Stalk sacrifice group achieved higher GTR (70.8 vs. 28%, p = 0.005). At last follow-up, there was no difference in recurrence/progression rates between the two groups.Conclusion There is a continuous evolution in the management of craniopharyngiomas. Gross total resection, higher rates of pituitary stalk and hormonal preservation, and low rates of postoperative CSF leak can be achieved with increased surgical experience.
Evaluating the effectiveness of the Kidogo model in empowering women and strengthening their capacities to engage in paid labor opportunities through the provision of quality childcare: a study protocol for an exploratory study in Nakuru County, Kenya
Authors: Okelo Kenneth , Nampijja Margaret , Ilboudo Patrick , Muendo Ruth , Oloo Linda , Muyingo Sylvia , Mwaniki Elizabeth , Langat Nelson , Onyango Silas , Sipalla Florence , Kitsao-Wekulo Patricia 
Published: July 2022

AbstractWorldwide, there is a wide gap between what women can contribute to the economy and what they actually contribute. One of the main barriers to women’s engagement in the labor market and productivity at work is the societal expectation that they should take care of their children in addition to meeting the demands of employment. Furthermore, those in informal employment face difficulties due to long working hours and environments that are not appropriate for childcare. To address this, Kidogo runs an innovative “Hub & Spoke” model for low-income communities. Here, we present a study protocol aimed at evaluating whether the provision of quality childcare opportunities for working women through the Kidogo model is feasible and acceptable and whether it contributes to improvements in their incomes and productivity at work. The study reported in this protocol which is currently ongoing, employed a quasi-experimental design with two study arms: primary caregivers who use childcare services were recruited into the intervention (n = 170) and comparison groups (n = 170). Both groups are being followed up for one year. We are using a mixed-methods approach. Appropriate statistical methods including a difference-in-differences (DID) estimator will be used to analyze the effects of the intervention. We expect that the intervention will improve the quality of childcare services which in turn will improve the incomes of the center providers. We expect that providing improved childcare services will enhance women’s economic empowerment.Trial registration: PACTR202107762759962.
Cascade GaN-based micro-photodiodes for photonic integration
Authors: Wang Bin , Liang Shihao , Yu Junchi , Xu Feifan , Zhang Dongqi , Tao Tao , Zhi Ting , Liu Xiaoyan , Zhuang Zhe , Xie Zili , Liu Bin , Zhang Rong 
Published: July 2022

Abstract
Photonic integrated circuit have attracted increasing attentions in many applications, such as visible light communication (VLC), optical on-chip interconnects, etc. In this work, we focus the study on photonic integration of GaN-based light-emitting diode (LED) and photodiode (PD). Integrated LED and multi-stage cascade PDs were designed and fabricated. Experimental results have demonstrated that the equivalent capacitance decreases continuously as the number of PD stages increasing. Compared to a single PD, the four-stage cascade PD can reduce the equivalent capacitance by 60%, making the cut-off frequency increased by 37%. Meanwhile, the cascade technique greatly reduces the dark current down to 20 pA and further improves the photo-to-dark current ratio up to 1.2 × 106 under a negative 5 V bias. Thus, the finding and experimental results in this work could enable a noval method to further improve VLC performances of photonic integrated devices.