bluuebunny/crossref_metadata_2025_split huggingface dataset:
pyhiiextractor: a tool to detect and extract physical properties of H ii regions from integral field spectroscopic data
Authors: Lugo-Aranda A Z , Sánchez S F , Espinosa-Ponce C , López-Cobá C , Galbany L , Barrera-Ballesteros J K , Sánchez-Menguiano L , Anderson J P 
Published: July 2022

Abstract
We present a new code named pyhiiextractor, which detects and extracts the main features (positions and radii) of clumpy ionized regions, i.e. candidate H ii regions, using $\rm {H}\,\alpha$ emission line images. Our code is optimized to be used on the dataproducts provided by the pipe3d pipeline (or dataproducts with such a format), applied to high-spatial resolution integral field spectroscopy data (like that provided by the AMUSING++ compilation, using muse). The code provides the properties of both the underlying stellar population and the emission lines for each detected H ii candidate. Furthermore, the code delivers a novel estimation of the diffuse ionized gas (DIG) component, independent of its physical properties, which enables a decontamination of the properties of the H ii regions from the DIG. Using simulated data, mimicking the expected observations of spiral galaxies, we characterize pyhiiextractor and its ability to extract the main properties of the H ii regions (and the DIG), including the line fluxes, ratios, and equivalent widths. Finally, we compare our code with other such tools adopted in the literature, which have been developed or used for similar purposes: pyhiiexplorer, sourceextractor, hiiphot, and astrodendro. We conclude that pyhiiextractor exceeds the performance of previous tools in aspects such as the number of recovered regions and the distribution of sizes and fluxes (an improvement that is especially noticeable for the faintest and smallest regions). pyhiiextractor is therefore an optimal tool to detect candidate H ii regions, offering an accurate estimation of their properties and a good decontamination of the DIG component.
Consumer Search and Prices in the Automobile Market
Authors: Moraga-González José Luis , Sándor Zsolt , Wildenbeest Matthijs R 
Published: July 2022

Abstract
This article develops a discrete choice model of demand with optimal sequential consumer search. Consumers first choose a product to search; then, once they learn the utility they get from the searched product, they choose whether to buy it or to keep searching. We characterize the search problem as a standard discrete choice problem and propose a parametric search cost distribution that generates closed-form expressions for the probability of purchasing a product. We propose a method to estimate the model that supplements aggregate product data with individual-specific data which allows for the separate identification of search costs and preferences. We estimate the model using data from the automobile industry and find that search costs have non-trivial implications for elasticities and markups. We study the effects of exclusive dealing regulation and find that firms benefit at the expense of consumers, who face higher search costs and higher prices than would be the case if multi-brand dealerships were used.
Prevalence of non-coeliac gluten sensitivity and assessment of the response to gluten-free diet in a cohort of patients with fibromyalgia
Authors: Almirall Miriam , Casellas Francesc , Dot Joan , de Torres Inés , Segurola Hegoi , Marsal Sara 
Published: July 2022

AbstractObjectivesTo establish the prevalence of non-coeliac gluten sensitivity (NCGS) in a cohort of fibromyalgia patients and to evaluate their clinical response to a six-week gluten-free diet (GFD), the improvement in their symptoms, the percentage of diet responders who did not fulfil the diagnostic criteria for NCGS and the baseline characteristics that were associated with diet response and diagnostic criteria fulfilment.MethodsUncontrolled prospective experimental study in a cohort of patients with fibromyalgia from a specialized hospital unit. The percentage of patients that fulfilled the Salerno Experts’ Criteria, that responded to GFD, that improved their symptomatology and baseline characteristics associated with GFD response and diagnostic criteria fulfilment was analysed.ResultsIn total, 142 patients were selected and a NCGS prevalence of 5.6% was observed. A total of 21.8% responded to GFD due to their improvement in intestinal symptoms. In total, 74.2% of the responders did not fulfil the Salerno Experts’ Criteria. The presence of diarrhoea and intraepithelial lymphocytosis and lower levels of anxiety were predictive factors of GFD response. No predictive factors of NCGS criteria fulfilment were found due to the low number of discriminators between gluten and placebo.ConclusionsA NCGS prevalence similar to that estimated in the general population was found. A GFD cannot be systematically recommended to all patients with fibromyalgia, although it could be evaluated in those with diarrhoea or intraepithelial lymphocytosis to evaluate if there are improvements in their intestinal symptoms.
Maternal Schizophrenia and the Risk of a Childhood Chronic Condition
Authors: Vigod Simone N , Ray Joel G , Cohen Eyal , Wilton Andrew S , Saunders Natasha R , Barker Lucy C , Berard Anick , Dennis Cindy-Lee , Holloway Alison C , Morrison Katherine , Oberlander Tim F , Hanley Gillian , Tu Karen , Brown Hilary K 
Published: July 2022

Abstract

Background and Hypothesis
Maternal schizophrenia heightens the risk for certain perinatal complications, yet it is not known to what degree future childhood chronic health conditions (Childhood-CC) might arise.

Study Design
This population-based cohort study using health administrative data from Ontario, Canada (1995–2018) compared 5066 children of mothers with schizophrenia to 25 324 children of mothers without schizophrenia, propensity-matched on birth-year, maternal age, parity, immigrant status, income, region of residence, and maternal medical and psychiatric conditions other than schizophrenia. Cox proportional hazard models generated hazard ratios (HR) and 95% confidence intervals (CI) for incident Childhood-CCs, and all-cause mortality, up to age 19 years.

Study Results
Six hundred and fifty-six children exposed to maternal schizophrenia developed a Childhood-CC (20.5/1000 person-years) vs. 2872 unexposed children (17.1/1000 person-years)—an HR of 1.18, 95% CI 1.08–1.28. Corresponding rates were 3.3 vs. 1.9/1000 person-years (1.77, 1.44–2.18) for mental health Childhood-CC, and 18.0 vs. 15.7/1000 person-years (1.13, 1.04–1.24) for non-mental health Childhood-CC. All-cause mortality rates were 1.2 vs. 0.8/1000 person-years (1.34, 0.96–1.89). Risk for children exposed to maternal schizophrenia was similar whether or not children were discharged to social service care. From age 1 year, risk was greater for children whose mothers were diagnosed with schizophrenia prior to pregnancy than for children whose mothers were diagnosed with schizophrenia postnatally.

Conclusions
A child exposed to maternal schizophrenia is at elevated risk of chronic health conditions including mental and physical subtypes. Future research should examine what explains the increased risk particularly for physical health conditions, and what preventive and treatment efforts are needed for these children.
Social Workers as Information Navigators: Insights into the Use of the Web for Serving Clients
Authors: Lee Wonhyung , Lee Eunwoo 
Published: July 2022

Abstract
Social workers’ critical role as service navigators on behalf of their clients is expanding in the online space at a faster pace than ever before. This study examined the process and outcome of online information navigation through the lens of service providers and service users based on observational and interactive surveys. T tests and correlation results showed that human services providers demonstrated a higher capacity to visit more websites and yield more accurate search outcomes in a similar duration of time compared with general service users. Results suggest that digital literacy for navigating information online can be improved through educational opportunities. At the same time, both groups shared some common feedback on desired features for future service navigation online, including but not limited to an open search bar, search filters, instruction videos, live chat, and discussion forums for seeking mutual help and networking. The findings bear implications for formulating the roles, responsibilities, and desired competencies of social workers for online service navigation in the digital and postpandemic future.
Grasping criteria for success: engaging undergraduate students in formative feedback by means of digital peer workshops
Authors: Albano Giovannina , Pierri Anna , Sabena Cristina 
Published: July 2022

Abstract
In our study we exploit digital tools in order to foster a relational approach to mathematics undergraduate students. Specifically, we designed formative assessment workshops based on peer feedback, with the aim to promote self-assessment and reflection on one’s own mathematical activity. In the paper we describe the design of an educational activity and investigate how the students perceived their experience with the designed formative assessment workshops. Furthermore, we provide evidence of the effectiveness of the designed workshops in terms of aligning students’ feedback with the teacher’s criteria.
9New Materialisms
Authors: Diener Samuel 
Published: July 2022

Abstract
The works reviewed in this year’s essay on the New Materialisms raise questions about the field’s orientation to knowledge creation and to its subjects of study, critiquing universalizing discussions of the Anthropocene, questioning notions of ‘pure’ or ‘pristine’ Nature, and proposing considerations for ethical and scholarly attention. Along the way, they touch on the problems of human ontology, employ the New Materialisms as a method for scholarship across the disciplines and for applied scholarly and creative work, raise the question of the New Materialisms’ political stakes (or lack thereof), and attempt to negotiate relationships between Western academic knowledge-making and other forms and situations of knowledge. Following an overview of these questions in the introduction, the essay is divided into four sections: 1. Utopia Now, focusing on Jayna Brown’s Black Utopias: Speculative Life and the Music of Other Worlds; 2. Clutter Culture, which discusses Rebecca R. Falkoff’s Possessed: A Cultural History of Hoarding; 3. National Dirt, on Mieka Erley’s On Russian Soil: Myth and Materiality; and 4. Cartographies of the Anthropocene, which considers Anna L Tsing, Jennifer Deger, Alder Keleman Saxena, and Feifei Zhou’s multimedia online project Feral Atlas: The More-Than-Human Anthropocene.
Efficacy and safety of hybutimibe on primary hypercholesterolemia: a randomized, double-blinded, placebo and positive–controlled, parallel phase II study
Authors: Qi Litong , Zhao Shuiping , Chen Jiyan , Zhang Mei , Li Xiaodong , Dong Yugang , Guo Xiaomei , Huang Kai , Wang Fang , Huo Yong , Ge Junbo 
Published: July 2022

Abstract

Background and purpose:
Hybutimibe is proved to be safe in healthy adults by a phase I study. A multi-center, randomized, double-blind phase II clinical trial evaluated its effectiveness and safety of Hybutimibe in the treatment of primary hypercholesterolemia.

Methods:
A total of 244 patients between August 2014 and August 2015, with primary hypercholesterolemia from 15 centers in China were enrolled and randomly assigned to receive placebo, ezetimibe, or hybutimibe 5, 10, or 20 mg/day in a 1:1:1:1:1 ratio. The primary outcome was evaluated from the change rate of low-density lipoprotein cholesterol (LDL-C) at week 8 from baseline, whereas secondary outcomes were evaluated from the change rates of LDL-C, TC, TG, HDL-C, non-HDL-C, APO-B, APO-A1 at weeks 1, 2, 4, and 8 from baseline.

Results:
After 8 weeks of treatment, the average decrease rate of LDL-C was −20.01% for ezetimibe, −10.84% (95% CI: −14.67, −7.00) for hybutimibe 5 mg/day, −17.06% (95% CI: −20.83, −13.29) for hybutimibe 10 mg/day, and −17.04% (95% CI: −20.30, −13.79) for hybutimibe 20 mg/day, respectively. The change rates of TC, non-HDL-C, and APO-B levels were significantly improved in all treatments compared with placebo (P < 0.05), whereas changes in the above lipid profiles of hybutimibe 20 mg/day were similar with ezetimibe. In terms of safety, the most common adverse events were elevation in ALT, gastrointestinal reaction, dizziness, and headache.

Conclusions:
This clinical study found that hybutimibe with the least dose of 5 mg/day effectively improved the LDL-C, TC, non-HDL-C, and APO-B levels in patients with primary hyperlipidemia with good tolerance and safety with no significant effect on TG levels.
Urinary Biomarkers of Polycyclic Aromatic Hydrocarbons and Timing of Pubertal Development: The California PAH Study
Authors: John Esther M. , Keegan Theresa H. , Terry Mary Beth , Koo Jocelyn , Ingles Sue A. , Nguyen Jenny T. , Thomsen Catherine , Santella Regina M. , Nguyen Khue , Yan Beizhan 
Published: July 2022

Background:
Polycyclic aromatic hydrocarbons (PAHs) are endocrine-disrupting chemicals. Few studies have evaluated the association between pubertal development in girls and PAH exposures quantified by urinary biomarkers.

Methods:
We examined associations of urinary PAH metabolites with pubertal development in 358 girls 6–16 years of age from the San Francisco Bay Area enrolled in a prospective cohort from 2011 to 2013 and followed until 2020. Using baseline data, we assessed associations of urinary PAH metabolites with pubertal development stage. In prospective analyses limited to girls who at baseline had not yet started breast (N = 176) or pubic hair (N = 179) development or menstruation (N = 267), we used multivariable Cox proportional hazards regression to assess associations of urinary PAH metabolites with the onset of breast and pubic hair development, menstruation, and pubertal tempo (interval between the onset of breast development and menstruation).

Results:
We detected PAH metabolites in >98% of girls. In cross-sectional analyses using baseline data, PAH metabolites were not associated with the pubertal development stage. In prospective analyses, higher concentrations (≥ median) of some PAH metabolites were associated with two-fold higher odds of earlier breast development (2-hydroxy naphthalene, 1-hydroxy phenanthrene, summed hydroxy phenanthrenes) or pubic hair development (1-hydroxy naphthalene) among girls overweight at baseline (body mass index-for-age percentile ≥85) compared with nonoverweight girls with lower metabolites concentrations. PAH metabolites were not associated with age at menarche or pubertal tempo.

Conclusions:
PAH exposures were widespread in our sample. Our results support the hypothesis that, in overweight girls, PAHs impact the timing of pubertal development, an important risk factor for breast cancer.
Esaxerenone Blocks Vascular Endothelial Inflammation Through SGK1
Authors: Yamamoto Hiroyasu , Yoshida Nao , Kihara Shinji 
Published: July 2022

Abstract:
Chronic low-grade inflammation and excess mineralocorticoid receptor (MR) activation are well-known pathological conditions of metabolic syndrome (MetS). To elucidate the crosstalk between inflammation and MR signaling, we focused on serum/glucocorticoid-regulated kinase 1 (SGK1) in vascular endothelial cells. We treated human aortic endothelial cells (HAECs) with esaxerenone (ESX), a novel nonsteroidal highly selective MR antagonist, or spironolactone (SPL), a classic competitive MR antagonist, followed by stimulation with tumor necrosis factor (TNF)-α. ESX at therapeutic concentrations attenuated the long-term induction of TNF-α–stimulated inflammatory molecules in HAEC, whereas SPL had only a minor effect at 10 μM. We found long-term TNF-α–stimulated induction of SGK1 mRNA and protein levels in HAEC and that ESX pretreatment significantly decreased SGK1 mRNA and protein levels at both the basal and the TNF-α–stimulated conditions, whereas SPL had no effect on SGK1 mRNA and protein levels. In addition, the TNF-α–induced nuclear factor kappa-light-chain-enhancer of activated B cell activity was suppressed by the treatment with ESX, and it was abrogated by SGK1 overexpression. These results indicated that ESX has direct anti-inflammatory effects in HAEC via the blocking of long-term TNF-α–induced SGK1 activation and that SGK1 could be a key molecule linking cytokine-induced vascular chronic inflammation and MR activation.
Barriers to surgical menopause counseling in gynecologic cancers: a quantitative and qualitative study of patients and providers
Authors: Wang Connor C. , Huang Dandi S. , Carlson Anisa M. , Li Zhanhai , Al-Niaimi Ahmed , Williams Makeba 
Published: July 2022

Abstract

Objective
The objective of this study is to identify factors associated with receiving surgical menopause counseling in gynecologic cancer patients, as well as patient and provider perspectives, regarding surgical menopause counseling and management.

Methods
We conducted a single-institution mixed-method study combining retrospective chart review and patient and provider surveys. Patients younger than 51 years who experienced surgical menopause after gynecologic cancer treatment from January 2017 to December 2019 were surveyed in April 2021 about experiences with menopause counseling, barriers to care, and quality of life. We then reviewed charts of only patients who fully completed surveys. All gynecologic oncology providers were surveyed about surgical menopause practices. Logistic regression identified factors associated with receiving counseling.

Results
Sixty-six of 75 identified met inclusion criteria and received survey invitations. Thirty-five (53%) completed surveys. Sixty percent had documented surgical menopause counseling. Patients who were counseled were younger (43 vs 48.5 years, P = 0.005), more likely to have referrals for menopause care (12 vs 9, P = 0.036), more likely to have menopause providers other than oncology providers (14 vs 8, P = 0.001), and had fewer comorbidities. Decreasing age at surgery increased odds of counseling. Most reported continued menopause symptoms and quality of life disturbances. Half were satisfied with menopause care. Majority preferred counseling from oncology providers. Most providers always counseled on surgical menopause but cited lack of time as the primary obstacle for complete counseling.

Conclusions
Younger age at surgery increased odds of receiving surgical menopause counseling. Gynecologic cancer patients experienced significant menopause-related disturbances. Improved understanding of patient and provider preferences and greater emphases on surgical menopause and survivorship will improve care for gynecologic oncology patients.
Evaluating the Quality and Reliability of Gender-affirming Surgery Videos on YouTube and TikTok
Authors: Song Siyou , Park Keon Min , Phong Kiet , Kim Esther A. 
Published: July 2022

Background:
Social media platforms have changed the way medical information is disseminated. Transgender patients may utilize social media to learn about gender-affirming surgery (GAS). Although videos on social media are readily accessible, their content is not verified or peer-reviewed. Therefore, this study aimed to evaluate the quality and reliability of YouTube and TikTok videos related to GAS.

Methods:
YouTube and TikTok were queried for gender-affirming top surgery, metoidioplasty, phalloplasty, breast augmentation, and vaginoplasty. Quality of video content was analyzed by the DISCERN scale. Quality scores were compared among the type of GAS, account user, and content category.

Results:
There were 275 YouTube videos and 55 TikTok videos. Most videos focused on masculinizing top surgery (P < 0.001). Overall, videos on masculinizing GAS had higher quality and reliability than videos on feminizing GAS (P < 0.001). Chest surgery videos were of higher quality than those on genital surgery (P ≤ 0.001). Videos on masculinizing top surgery had the highest quality, whereas vaginoplasty had the lowest quality and reliability (P < 0.001). Videos produced by health care professionals and academic institutions had the greatest quality and reliability, respectively (P < 0.0001), whereas videos produced by patients were the least reliable (P < 0.0001).

Conclusions:
Videos on GAS ranged from poor to good quality and reliability. Health care professionals, especially plastic surgeons, should create high-quality videos on social media to educate transgender patients. There should also be greater efforts in disseminating existing high-quality videos on social media. Resources posted on social media platforms can reach a wide audience through accessible means.
Safety and Feasibility of Infliximab Therapy in Children With Kawasaki Disease Who Received Live Vaccinations
Authors: Ohnishi Yuji , Okada Seigo , Kawakami-Miyake Akiko , Furuta Takashi , Fukano Reiji , Yasudo Hiroki , Shimokawa Mototsugu , Hasegawa Shunji 
Published: July 2022

Background:
Kawasaki disease (KD) is an acute and febrile systemic vasculitis that occurs during childhood. Infliximab (IFX) is a chimeric monoclonal antibody that binds to tumor necrosis factor-α. Although IFX therapy is a useful option for refractory KD, vaccine-associated infections may develop after therapy. In Japan, IFX therapy is recommended after a duration of at least 3 months after live vaccinations or at least 6 months after Bacillus Calmette-Guérin (BCG) in children with KD. However, the appropriate duration between live vaccinations and IFX therapy is unclear.

Methods:
We investigated children who developed KD within 3 months after live vaccinations or within 6 months after BCG. Clinical characteristics, side effects of therapies and efficacy of live vaccinations were retrospectively investigated.

Results:
Forty-eight patients developed KD within 3 months of live vaccinations or within 6 months after BCG. Eight patients underwent IFX therapy. There were no apparent vaccine-associated infections. The patients who underwent IFX acquired protective IgG antibody titers in the 5 of 6 live vaccines.

Conclusions:
Safe and appropriate duration between live vaccinations and IFX therapy for KD patients could be shorter in the future, although more studies are warranted to establish the safe duration.