bluuebunny/crossref_metadata_2025_split huggingface dataset:
Celecoxib added to risperidone for depressive symptoms in first-episode and drug naïve schizophrenia: Pharmacogenetic impact of BDNF gene polymorphisms
Authors: Zhang Xiangyang , Chen Dachun , Xiu Meihong , Zhou Huixia , Kosten Thomas , Wang Dongmei 
Published: June 2022

Abstract
Although depressive symptoms are common in patients with schizophrenia (SCZ), depression is not successfully treated in most SCZ patients. SCZ Patients with comorbid depression may have activated inflammatory responses, and celecoxib, a COX2 inhibitor, can dampen inflammation and improve treatment of depression. BDNF may be associated with the treatment response to antidepressants and has an important role in inflammation associated with depression. Therefore, we intended to explore the efficacy of celecoxib augmentation for depressive symptoms in SCZ patients and its possible relationship with BDNF serum levels and two BDNF genotypes. In a case-control study, two BDNF polymorphisms (rs6265 and rs10835210) were genotyped in 308 first-episode and drug-naïve (FEDN) SCZ patients and 422 healthy controls. Serum BDNF levels were measured in 239 patients and 259 healthy controls. We then randomly assigned 90 FEDN SCZ patients to enter a double-blind, randomized and placebo-control 12-week treatment with 400 mg per day of celecoxib. We assessed clinical efficacy with the Hamilton Depression Rating Scale (HAMD) and psychiatric symptoms with the Positive and Negative Syndrome Scale (PANSS). Our results showed that SCZ patients had lower BDNF levels than healthy controls. BDNF levels were associated with PANSS total score, positive symptoms, general psychopathology and HAMD total score. The BDNF gene rs10835210 was associated with SCZ susceptibility, positive symptoms and BDNF serum levels in SCZ patients. Celecoxib treatment significantly improved depressive symptoms compared to placebo treatment. Furthermore, patients in the BDNF rs10835210 CC group showed significantly more improvement in depressive symptoms than the A allele carrier group. Our findings suggest that COX2 inhibitors may be a promising therapeutic agent for the treatment of comorbid depressive symptoms in FEDN SCZ patients. The BDNF system may be involved in the pathogenesis of depressive symptoms in SCZ patients and forms the pharmacogenetic basis for improvement after treatment with COX2 inhibitor.
Artificial Intelligence for Clinical Decision Support in Acute Ischemic Stroke Care: A Systematic Review
Authors: Hilbert Adam , Akay Ela , Carlisle Benjamin , Madai Vince , Mutke Matthias , Frey Dietmar 
Published: June 2022

Abstract
Established randomized-trial-based parameters for acute ischemic stroke care fail to consider individualized patient data, leading to attempts to support or automate treatment and diagnosis decisions using artificial intelligence methods. We review existing research, specifically regarding methodological robustness, thereby identifying constraints for clinical AI implementation.

Our systematic review of clinical decision support systems (CDSS) includes full-text English language publications proposing AI-based methods for decision support in acute ischemic stroke cases in adult patients. We (a) describe data and outcomes used in those systems, (b) estimate the systems’ benefits compared to traditional stroke diagnosis and treatment, and (c) report concordance with the MINIMAR checklist.

121 studies met our inclusion criteria. 65 were included for full extraction. In our sample, utilized data sources, methods, and reporting practices were highly heterogeneous; adherence to the MINIMAR checklist was low.

Our results suggest significant validity threats, dissonance in reporting practices and challenges to clinical translation. We outline practical recommendations for successful implementation of AI in acute ischemic stroke treatment and diagnosis.
Inonotus obliquus (Fr.) Pilat (IOPE) ameliorates immune response via LKB1- Bax-Casepase-3-PARP pathways in B16-F10 cells induced low immunity BALB/c mice model
Authors: Lu Youyou , Zhou Xiaohong , Liang Xi , Wu Yeting , Wang Ruiqi , Zhang Zhe , Gong Pimin , Liu Tongjie , Yi Huaxi , Yu Zhuang , Zhang Lanwei 
Published: June 2022

Abstract
Objective: Inonotus obliquus (Fr.) Pilat extract (IOPE) is a major active carbohydrate, an important herb used in traditional medicine, the aim of this study was to investigate the immunomodulatory effects and possible underlying mechanisms of IOPE in B16-F10 cells induced low immunity mice. Material and Methods: IOPE was extracted and prepared, the inhibitory effect on B16-F10 cells was determined in vitro, different concentrations of the IOPE (0.1, 0.2, 0.4, 0.8 mg/mL) were added to cells for 2, 12, 24, 48 h. BALB/c mice model was established by B16-F10 cells, and the IOPE (500, 250, 125 mg/kg/bw) were oral administration into mice. Results: The IOPE could not only owned inhibitory effect on B16-F10 cells (0.8 mg/mL), but also had a potent immune response improvement (250 mg/kg/bw), and effectively improved spleen immune index, CD3+ and CD8+ cell expression (79.8%,20.1%), strengthened phagocytosis of macrophages, significantly inhibited the over expression of inflammatory factors IL-6(308.02±6.48 pg/mL), IL-8(381.84±8.93 pg/mL), TNF-α(1877.50±11.11 pg/mL), promoted the expression of anti-inflammatory factor IL-10 (419.90±5.55 pg/mL), finally activated the LKB1-Bax-Casepase-3-PARP pathway. Conclusions: IOPE might be potentially used as an effective regulator for the immunity improvement in future.
High-Transconductance, Highly Elastic, Durable and Recyclable All-Polymer Electrochemical Transistors with 3D Micro-engineered Interfaces
Authors: Xie Zhuang 
Published: June 2022

Abstract
Organic electrochemical transistors (OECTs) have emerged as versatile platforms for broad applications spanning from flexible and wearable integrated circuits to biomedical monitoring to neuromorphic computing. Various materials and tailored micro/nanostructures have been recently developed to realized stretchable OECT devices that accommodate the complex deformation, however, a solid-state OECT with high elasticity has yet to be demonstrated. Herein we developed a general platform for the facile creation of highly elastic all-polymer OECTs, with high transconductance up to 12.7 mS, long-term mechanical and environmental stability, as well as recyclability. Rapid prototyping of such devices was achieved simply by transfer printing PEDOT:PSS/LiTFSI microelectrodes onto a resilient gelatin-based gel electrolyte, in which both depletion- and enhancement-mode OECTs were produced based on various active channel materials. Moreover, the 3D architectures of the PEDOT:PSS electrodes and channels were elaborately engineered by soft lithographic approaches, allowing well-defined channel geometry and patterned morphologies at microscales. Remarkably, an imprinted 3D-microstructured channel/electrolyte interface in combination with wrinkled electrodes afforded OECT performance retained under biaxial stretching of 100% strain and 1000 repeated cycles of 80% strain. And the all-polymer OECTs were demonstrated to reliably operate in proof-of-concept on-skin, synapse-mimicking and biosensing applications. Additionally, the anti-drying and degradable gelatin electrolyte with the self-crosslinked PEDOT:PSS/LiTFSI jointly enabled stable performance for > 4 months in ambient conditions, as well as on-demand disposal and recycling. Thus, this work presents a straightforward approach towards the development of high-performance stretchable organic electronics for wearable/implantable/sustainable soft devices.
Biogenic synthesis of ZnO nanoparticles as green adsorbent for catalytic breakdown and dye remediation
Authors: Ahmed Rabia , Rana Priyanka , Siddiqui SharfIlahi , Fatma Bushra , Ahmed Shakeel , Chaudhry Saif Ali 
Published: June 2022

Abstract
Zinc oxide nanoparticles were developed by a facile green synthesis approach using plant extractions of Casuasina equisetfolia . The confirmative preparation and morphology of synthesized ZnO NPs are analyzed by the FTIR, XRD, SEM, DLS, and TEM technologies. FTIR confirms the preparation of ZnO NPs, and XRD, SEM, and TEM gave the surface structure and morphological information of ZnO NPs. ZnO NPs particle size was11-13 nm with amorphous nature having uniform distribution. Synthesized ZnO NPs were further applied as photocatalysts to degrade hazardous dye, Orange G, and gave a significant result. The adsorption behavior of ZnO NPs was also evaluated for Congored dye, which could effectively treat dye from an aqueous medium. The sorption results coordinate well with the Dubinin-Radushkevich isotherm (D-R) paradigm. The optimum monolayered sorption efficacy of ZnO NPs for CR was 42.01mgg -1 . Reaction kinetics obeyed the pseudo-second-order, and thermodynamics of sorption of CR onto ZnO NPs exhibited that the mechanism was endothermic and spontaneous. Therefore, the present study is economically and environmentally sound for water treatment.
Developing a multi-stakeholder intervention for Lynch syndrome cascade screening: an intervention mapping approach
Authors: Passero Lauren , Srinivasan Swetha , Grewe Mary E , Leeman Jennifer , Berg Jonathan , Reuland Daniel , Roberts Megan C 
Published: June 2022

Abstract

Background
Lynch syndrome is an underdiagnosed hereditary condition carrying an increased lifetime risk for colorectal and endometrial cancer and affecting nearly 1 million people in the United States. Cascade screening, systematic screening through family members of affected patients, could improve identification of Lynch syndrome, but this strategy is underused due to multi-level barriers including low knowledge about Lynch syndrome, low access to genetics services, and challenging family dynamics.
Methods
We used intervention mapping, a 6-step methodology to create stakeholder-driven interventions that meet the needs of a target population, to develop an intervention to improve cascade screening for Lynch syndrome. The intervention development process was guided by input from key stakeholders in Lynch syndrome care and patients. We conducted usability testing on the intervention with Lynch syndrome patients using qualitative semi-structured interviewing and rapid qualitative analysis.
Results
We developed a workbook intervention named Let’s Talk that addresses gaps in knowledge, skills, self-efficacy, outcome expectancy and other perceived barriers to cascade screening for Lynch syndrome. Let’s Talk contained educational content, goal setting activities, communication planning prompts and supplemental resources for patients to plan family communication. Evidence-based methods used in the workbook included information chunking, guided practice, goal setting and gain-framing. Usability testing results suggested the intervention was acceptable in terms of complexity and relative advantage to other available resources, but additional information for communication with young or distant family members and a web-based platform could enhance the intervention’s usability.
Conclusions
Intervention mapping provided a framework for intervention development that addressed the unique needs of Lynch syndrome patients in overcoming barriers to cascade screening. Future work is needed to transform Let’s Talk into a web-based tool and evaluate the effectiveness of the intervention in clinical practice with patients and genetic counselors. Intervention mapping can be useful to researchers as an evidence-based technique to develop stakeholder-centered interventions for addressing the needs of other unique populations.
Membrane bioreactor (MBR) performance in fish canning industrial wastewater treatment
Authors: Ayyoub H. , Kitanou S. , Bachiri B. , Tahaikt M. , Taky M. , Elmidaoui A. 
Published: June 2022

Abstract
The fish canning industries produce a large amount of wastewater. The high-strength wastewater from fish processing industry is of great concern worldwide. This type of wastewater is rich in organic matter and has high total dissolved solids (TDS). The elimination of salts is usually expensive and, on the other hand, the high salinity and the seasonal variation of the effluent characteristics make the removal of organic matter difficult using only a biological process. For this purpose, the use of a membrane bioreactor (MBR) process combining both a biological treatment and ultrafiltration membrane separation could be a perfect option for fish canning wastewater treatment. In this work, the performance of a MBR process is investigated to treat the fish canning industry wastewater. The removal efficiency of important parameters such as chemical oxygen demand (COD), five day-biological oxygen demand in (BOD5), total suspended solids (TSS), nitrate (NO3−), total Kjeldahl nitrogen (TKN), orthophosphate (PO43−) and TDS are followed. Experimental results show that the overall removal efficiencies obtained are: 96.6% for COD, 98% for BOD, 99.5% for TSS, 90% for nitrate, 96% for TDS and greater than 97% for TKN and PO43−. These results confirm that combination of both biological treatment and membrane process is regarded as an effective approach to reduce the contaminants in fish canning wastewater. Membrane bioreactor presents several advantages in terms of water resource protection because of the great quality of the treated water that can be reused.
Distribution pattern and ecological risk assessment of heavy metals in Henan section of the Yellow River
Authors: Zhang Kai , Li Kuangjia , Xin Rui , Xu Zhiheng , Zhang Zhongshuai , He Siyu , Zhao Zhenzhen , Tong Minghui , Cui Yongxin 
Published: June 2022

Abstract
Heavy metals (HMs) pollution in the environment is a persistent issue and draws public attention constantly. However, there is little research assessing the pollution level of HMs in the Henan section of the Yellow River although the river is one of the most important water supply rivers in Henan province. In this research, the fraction contents of six HMs in the Henan section of the Yellow River were investigated by adopting the European Community Bureau of Reference (BCR) sequential extraction procedure. Moreover, the potential health risk caused by HMs was evaluated by adopting both the geo-accumulation index (Igeo) and ecological hazard index method. The results indicate the presence of a light HM pollution level in the Yellow River generally. However, the health risk caused by Cd cannot be neglected. Fraction analysis indicates that the content of the B2 fraction is high, which needs more attention. Overall, branch afflux might be one of the important pathways through which anthropogenic activities influence the Yellow River. The results of both the Igeo and ecological hazard index indicate that the potential health risk caused by HMs is low in the Yellow River, and the Yellow River protection policies implemented by Henan province may be the underlying reason.
Cardiotoxicity of Biological Therapies in Cancer Patients: An In-depth
Review
Authors: Madanat Luai , Gupta Ruby , Weber Paul , Kumar Navneet , Chandra Rohit , Ahaneku Hycienth , Bansal Yatharth , Anderson Joseph , Bilolikar Abhay , Jaiyesimi Ishmael 
Published: June 2022

Abstract:
Cardiotoxicity from chemotherapy regimens has been long reported. However, the understanding
of cardiac side effects of biological therapies is rapidly evolving. With cancer patients
achieving higher life expectancy due to the use of personalized medicine and novel targeted anticancer
agents, the occurrence of cardiotoxicity is becoming more significant. Novel biological
therapies include anti-HER2 antibodies, tyrosine kinase inhibitors, bruton kinase inhibitors, antivascular
endothelial growth factors, proteasome inhibitors, immunomodulator drugs, and immune
checkpoint inhibitors. Potential cardiovascular toxicities linked to these anticancer agents include
hypertension, arrhythmias, QT prolongation, myocardial ischemia and infarction, left ventricular
dysfunction, congestive heart failure, and thromboembolism. Cardiac biomarkers, electrocardiography,
echocardiography and magnetic resonance imaging are common diagnostic modalities used
for early detection of these complications and timely intervention. This review discusses the various
types of cardiotoxicities caused by novel anticancer biologic agents, their molecular and pathophysiological
mechanisms, risk factors, and diagnostic and management strategies that can be
used to prevent, minimize, and treat them.
The Anticonvulsant Activity of Thiamine, Vitamin D3, and Melatonin Combination on Pentylenetetrazole-induced Seizures in Mice
Authors: Hosseinzadeh Azam , Mehrzadi Saeed , Dehdashtian Ehsan , Karimi Mohammad Yahya 
Published: June 2022

Objective:Epilepsy is a neurological disorder associated with the elevation of oxidative stress levels and alteration in vitamins and endogenous antioxidant levels. The current study was designed to evaluate the effects of Vit D3, thiamine, melatonin, and their combination on pentylenetetrazol (PTZ)-induced tonic-clonic seizures in mice along with measuring the alteration in oxidative stress markers.Methods:Male mice were randomly divided into seven groups; group I received normal saline (0.5 ml, i.p.) on the 15th day, group II received PTZ (60 mg/kg, i.p) on the 15th day, groups III-VI received diazepam (4 mg/kg), Vit D3 (6000 IU/kg, p.o.), thiamine (200 mg/kg, p.o.), and melatonin (20 mg/kg, p.o.), respectively, before PTZ (60 mg/kg, i.p.) injection on the 15th day, and group VII received the combination of Vit D3, thiamine, and melatonin, before PTZ injection on the 15th day. After PTZ injection, the seizure latency and duration were measured. The malondialdehyde (MDA) level and superoxide dismutase (SOD) activity were evaluated in mice brains.Results:In the treatment group, the seizure latency was greater and the seizure duration was lower than in the PTZ group. These agents decreased the MDA level and increased SOD activity compared to the PTZ group. The combination of these agents was more effective than each alone to increase seizure latency and reduce seizure duration.Conclusion:The combination of Vit D3, thiamine, and melatonin could improve PTZ-induced seizures more effectively than each one alone; this may be mediated by inhibiting oxidative stress and regulating various mechanisms involved in seizures.
Antihypertensive and Vasorelaxant Effects of Rumex vesicarius (L.)
through Receptor-Operated Calcium Channels in Hypertensive Rats
Authors: Eddouks Mohamed , Amssayef Ayoub , Bouadid Ismail , EL-Haidani Ahmed 
Published: June 2022

Aims:
The aim of the study was to assess the antihypertensive activity of Rumex vesicarius.

Background:
The genus Rumex (sorrel, Polygonaceae), containing approximately 200 species, is distributed worldwide (African, European, Asian, and American countries). It is widely used in traditional medicine as analgesic, diuretic, antispasmodic, and antihypertensive plants.

Objective:
This study aimed to assess the possible antihypertensive vasorelaxant capacity and effect on angiotensin-converting enzyme 2 (ACE-2) of the aqueous extract of Rumex vesicarius (R. vesicarius).

Material and Methods:
In the present study, the aqueous extract of R. vesicarius (AERV) was prepared, its antihypertensive activity was examined in N(ω)-nitro-L-arginine methyl ester(L-NAME)-induced hypertensive rats, and its vasorelaxant ability along with its effect on stimulating or inhibiting ACE-2 were performed in isolated rat thoracic aorta.

Results:
The results indicated that AERV decreased the systolic, diastolic, mean, and mean arterial blood pressure in hypertensive rats. The data revealed that AERV exerted its antihypertensive effect through vasodilatory properties via an endothelium-independent pathway. Interestingly, the study demonstrated that the vasorelaxation ability of AERV might be mediated through receptor-operated calcium channels (ROCC). However, AERV extract had no effect on either stimulating or inhibiting ACE-2.

Conclusion:
The present study demonstrates clearly the antihypertensive and vasorelaxant activities of R. vesicarius in hypertensive rats, supporting its beneficial action as an antihypertensive agent.
Creatinine Clearance Measurement with Bioelectrical Impedance Analysis
in Heart Failure Patients: Comparison with Estimated-Creatinine Clearance
Formulas
Authors: Scicchitano Pietro , Iacoviello Massimo , Guida Piero , De Palo Micaela , Potenza Angela , Basile Marco , Sasanelli Paolo , Trotta Francesco , Sanasi Mariella , Caldarola Pasquale , Massari Francesco 
Published: June 2022

Background:
Kidney disease is common in patients with heart failure (HF). The Donadio
equation combines plasma creatinine and bioimpedance vector analysis (BIVA) to estimate creatinine
clearance. This study aimed to compare the Donadio formula to the Cockcroft-Gault (CG), Modification
of Diet in Renal Disease Study (MDRD-4), and Chronic Kidney Disease Epidemiology
Collaboration (CKD-EPI) equations in patients with HF.

Methods:
We analysed data from 900 patients (mean age: 76 ± 10 years) with HF. All of them underwent
clinical, laboratory, BIVA, and echocardiographic evaluations.

Results:
Donadio equation overestimated eGFR as compared to CG and CKD-EPI formulas (+6.8
and +12 mL/min/1.73 m2, respectively) while computing similar results to MDRD-4 (overestimation:
+0.1 mL/min/1.73 m2).

:
According to the different formulas, the prevalence of renal insufficiency (eGFR< 30 ml/min/1.73
m2) in relation to the different formulas was as follows: 24% with Donadio, 21% with CG, 13% with
MDRD-4, and 23% with CKD-EPI formulas. All the equations demonstrated a high precision rate
(r>0.8 for all).

Conclusions:
The Donadio formula provided an estimation of GFR comparable to MDRD-4 in HF
patients, independently from acute or chronic HF conditions. The use of BIVA in HF patients may
be adopted both for HF management and for evaluating kidney function.