bluuebunny/crossref_metadata_2025_split huggingface dataset:
YAŞLI BİREYLER İÇİN GELENEKSEL YAPILARIN ERİŞİLEBİLİRLİK DEĞERİ ÜZERİNE BİR İNCELEME: MALATYA BEŞKONAKLAR EVİ
Authors: AKÇA Meryem , AKYILDIZ Nihal Arda 
Published: November 2022

Kentlerin ilk yerleşim alanları olarak kabul gören geleneksel yerleşim alanlarında sürdürülen sosyal yaşam, fiziki çevreyle yakından ilişkilidir. Geleneksel yerleşim alanları, kentsel planlama içinde kimi zaman merkeze alınmış kimi zaman da kent merkezinden oldukça uzakta bırakılmıştır. Tüm kent kullanıcıları gibi hareket kısıtlılığına sahip yaşlı kullanıcıların da kentin her noktasına erişiminin önemi, sosyal yaşamın tartışılmaz bir gerçeğidir. Bu nedenle nüfus yapısı içinde hatırı sayılır orana sahip olan bu kent kullanıcılarının, sosyal yaşama katılımları ve mekânsal konfor düzeylerinin arttırılmasını sağlayan erişilebilirlik standartlarının önemine dikkat çekmek gerekmektedir. Erişilebilirliğin ulusal ve uluslararası standartlarla ortaya koyduğu ilkeler, tüm bireylerin eşit koşullarda, kesintisiz, sağlıklı ve güvenli şekilde yaşamlarını sürdürebilmeleri için mekânsal düzenlemeler yanında toplumsal yaşamın sürdürülebilirliği açısından da büyük önem arz etmektedir. Kentin geleneksel yerleşim alanlarında da kullanıcılarının tüm hizmetlere kolaylıkla erişilebilmeleri için yapılacak düzenlemeler, yaş almakta olan bireylerin gündelik yaşam katılımlarını arttırmada ve sosyo-kültürel yaşamı desteklemede önemli yer tutmaktadır.
Çalışma bu anlamda ele alınarak kentlerin geleneksel yerleşim alanlarındaki erişilebilirlik düzeyi yanında hareket kısıtlılığına sahip yaşlı kent kullanıcılarının karşılaştığı sorunlara dikkat çekmeyi amaçlanmıştır. Bu bağlamda konunun irdelenmesi için seçilen Malatya ilinde yer alan Beşkonaklar Evi ve çevresinin erişilebilirlik standartlarını ne oranda karşıladığı incelenmiş ve yerinde yapılan analizlerle erişilebilirlik konusunun yaşlı kent kullanıcıları için öneminin ortaya konması hedeflenmiştir.
Integrated machine learning and GIS-based bathtub models to assess the future flood risk in the Kapuas River Delta, Indonesia
Authors: Sampurno Joko , Ardianto Randy , Hanert Emmanuel 
Published: November 2022

AbstractAs more and more people live near the sea, future flood risk must be properly assessed for sustainable urban planning and coastal protection. However, this is rarely the case in developing countries where there is a lack of both in-situ data collection and forecasting tools. Here, we consider the case of the Kapuas River Delta (KRD), a data-scarce delta on the west coast of Borneo Island, Indonesia. We assessed future flood risk under three climate change scenarios (RCP2.6, RCP4.5, and RCP8.5). We combined the multiple linear regression and the GIS-based bathtub inundation models to assess the future flood risk. The former model was implemented to model the river's water-level dynamics in the KRD, particularly in Pontianak, under the influence of rainfall changes, surface wind changes, and sea-level rise. The later model created flood maps with inundated areas under a 100-year flood scenario, representing Pontianak's current and future flood extent. We found that about 6.4%–11.9% more buildings and about 6.8%–12.7% more roads will be impacted by a 100-year flood in 2100. Our assessment guides the local water manager in preparing adequate flood mitigation strategies.
The eco-friendly treatment of rubber industry effluent by using adsorbent derived from Moringa oleifera bark and Pseudomonas sp, cultured from effluent
Authors: Das Joydeep , Mondal Abhijit , Biswas Srijit , Nag Soma 
Published: November 2022

Abstract
Rubber processing generates a large volume of wastewater containing rubber latex residues and chemicals. Remediation of the wastewater needs a cost-effective and environment-friendly treatment method. For this study, Moringa oleifera stem bark and Pseudomonas sp. bacteria were used for adsorption and microbial treatment of the effluent. The adsorbent surface was mostly amorphous with crystallinity index 37.9 % and the BET surface area was 6.622 m2/g. FTIR analysis indicated involvement of O-H stretching, ketone α, β- unsaturated, C-H stretching, carboxylic acid and derivatives O-C stretching functional groups in the adsorption process. The assessment of the above two agents was based on their reduction capabilities of the toxic parameters, such as total suspended and dissolved solids, total solids, biological and chemical oxygen demand, sulphate, ammonium, dissolved oxygen, phosphate, pH, electrical conductivity, turbidity, and oxidation reduction potential from the wastewater. A comparative study of the present work revealed that both the agents were effective in reduction of most of the above parameters below the safe discharge limits. However, the adsorption using Moringa oleifera stem bark was better compare to the biodegradation by Pseudomonas sp. bacteria. The main challenges that typically accompany biodegradation include microbe handling and a lower removal percentage than adsorption.
A ANÁLISE DO CLIMA ESCOLAR COMO PARADIGMA PARA UM NOVO CUIDADO
Authors: De Azevedo Machado Flávia Christiane , Diniz Papa Thomas , Ferreira de Oliveira Suelen , Pinheiro Suassuna Alice , Loos Félix Giovanni 
Published: November 2022

Introdução: O clima escolar é a percepção do estudante sobre a instituição no tocante às relações interpessoais, infraestrutura, engajamento comunitário, cogestão, entre outros. Objetivo: caracterizar o clima escolar a partir da percepção dos estudantes, evidenciando as dimensões mais frágeis e as mais estabelecidas. Metodologia: Desenvolveu-se estudo transversal com 129 estudantes matriculados no ano de 2018 no segundo ano do ensino médio em escolas estaduais de Natal/RN. Esses responderam a um questionário para identificação do perfil socioeconômico e clima escolar. Foram calculadas as frequências e medidas de tendência central das variáveis. Resultados: Cerca de 80% dos estudantes concordaram gostar estar na escola ou sentir ter bons amigos nela; 70% afirmam ser boa a relação entre todos os atores da escola; 67,20% sentem que quem trabalha na escola gosta do que faz. Todavia, 40% dos alunos não sentem orgulho da escola, 32% concordaram que todos participam das tomadas de decisões importantes na escola e 53% disseram sentir-se seguros na escola. Conclusões: Conclui-se que Gestão & Transparência e a Infraestrutura são as dimensões mais frágeis do clima escolar, enquanto as melhor estabelecidas são Amizade, Relações Interpessoais, Acolhimento e Igualdade e Colaboração Mútua.
Palavras-Chave: Promoção da Saúde. Promoção da Saúde Escolar. Avaliação em saúde.
The Anti-MRSA Activity of Phenylthiazoles: A Comprehensive Review
Authors: Kassab Asmaa E. , Shahin Inas G. , Mohamed Khaled O. , Taher Azza T. , Mayhoub Abdelrahman S. 
Published: November 2022

Abstract:
Antimicrobial resistance is an aggravating global issue therefore it has been under extensive research
in an attempt to reduce the number of antibiotics that are constantly reported as obsolete jeopardizing the lives
of millions worldwide. Thiazoles possess a reputation as one of the most diverse biologically active nuclei, and
phenylthiazoles are no less exceptional with an assorted array of biological activities such as anthelmintic, insecticidal, antimicrobial, antibacterial, and antifungal activity [1]. Recently phenyl thiazoles came under the
spotlight as a scaffold having strong potential as an anti-MRSA lead compound. It is a prominent pharmacophore in designing and synthesizing new compounds with antibacterial activity against multidrug-resistant bacteria such as MRSA, which is categorized as a serious threat pathogen, that exhibited concomitant resistance to
most of the first-line antibiotics. MRSA has been associated with soft tissue and skin infections resulting in
high death rates, rapid dissemination, and loss of millions of dollars of additional health care costs [2]. In this
brief review, we have focused on the advances of phenylthiazole derivatives as potential anti-MRSA from 2014
to 2021. The review encompasses the effect on biological activity due to combining this molecule with various
synthetic pharmacophores. The physicochemical aspects were correlated with the pharmacokinetic properties
of the reviewed compounds to reach a structure-activity relationship profile. A summary of antibacterial activity
of phenylthiazole derivatives against MRSA was added in a tabular form (Table 1). Lead optimization of phenyl thiazole derivatives has additionally been outlined where the lipophilicity of the compounds was balanced
with the metabolic stability and oral solubility to aid the researchers in medicinal chemistry, design, and synthesizing effective anti-MRSA phenylthiazoles in the future.
An Expeditious Synthesis of Ethyl-2-(4-(arylmethylene)-5-oxo-4,5-dihydroisoxazol-3- yl)acetate Derivatives
Authors: Delfani Ali Moradi , Kiyani Hamzeh , Zamani Mehdi 
Published: November 2022

Abstract:In this contribution, an operationally simple and efficient synthetic procedure for synthesizing derivatives of 4-(arylmethylene)-5-oxo-4,5-dihydroisoxazol-3-yl)acetate has been developed. This interesting synthetic protocol involves the one-pot cyclocondensation of diethyl 3-oxopentanedioate, aryl or heteroaryl aldehydes, and hydroxylamine hydrochloride catalyzed in an aqueous medium using an azolium salt as a robust organo-catalyst. In this work, for the first time, 1,3-dibenzyl-1H-benzo[d]imidazol-3-ium chloride was used as the catalyst for the synthesis of ethyl-2-(4-(arylmethylene)-5-oxo-4,5-dihydroisoxazol-3-yl)acetate derivatives from the commercially available starting materials. Notably, no by-products were observed during the multicomponent reaction. Optimization studies revealed that 5 mol% of 1,3-dibenzyl-1H-benzo[d]imidazol-3-ium chloride is sufficient to perform the experiment. Furthermore, examining the results of the temperature conditions showed that 70 ºC is the best temperature to carry out the reaction. In an optimization study, H2O was the most effective solvent to perform the three-component cyclization reaction. In this method, using H2O as the environmentally benign and inexpensive reaction medium, so from the point of view of the reaction medium, it can be said that this three-component heterocyclization obeys the principles of green chemistry. This procedure has several advantages, such as good to excellent yields, reasonable reaction times, isolation of heterocyclic products without column chromatography or other chromatographic methods, atom-economy, step-economy, and clean reaction profiles.
Comprehensive Metabolism Study of Tangeretin in Rat Plasma, Urine and Faeces
Using Ultra-High Performance Liquid Chromatography-Q Exactive Hybrid Quadrupole-
Orbitrap High-Resolution Accurate Mass Spectrometry
Authors: Yu Xiaojun , Cong Zhufeng , Wang Changlin , Wang Shengguang , Yan Zhi , Wang Bin , Liu Xiaonan , Li Zhen , Gao Peng , Kang Huaixing 
Published: November 2022

Background:
Tangeretin, present in citrus fruits, is a polymethoxy flavone with extensive pharmacological
effects. It has been widely used in the clinic, but there were no detailed studies on the in vivo metabolism of tangeretin.

Objective:
This study aimed to establish a rapid and effective strategy to identify the metabolites of tangeretin and
evaluate the biotransformation pathways of tangeretin in rats.

Methods:
The ultra-high performance liquid chromatography (UHPLC) equipped with a Q-Exactive Orbitrap mass
spectrometer was used to identify the metabolites of tangeretin in plasma, urine and faeces of rats after intragastric
administration. Based on high-resolution extracted ion chromatograms (HREICs) and parallel reaction monitoring
mode (PRM), metabolites of tangeretin were identified by comparing the accurate mass, chromatographic retention
times, diagnostic product ions (DPIs) and neutral loss fragments (NLFs) with those of tangeretin reference standard.
Isomers were distinguished by ClogP values.

Results:
An efficient and integrated strategy was established for the comprehensive screening and characterizing of
tangeretin metabolites through Rapid Profiling. Based on this strategy, a total of 52 metabolites were detected and
identified, among which 25 metabolites were found in rat plasma, while 48 and 16 metabolites were characterized
from rat urine and faeces, respectively. These metabolites were produced by demethylation, demethoxylation, hydroxylation,
methoxylation, glucuronidation, glycosylation, sulfation, and their composite reactions. Interestingly,
tangeretin is easy to lose methyl in vivo and becomes an intermediate product, and then other phase I and phase II
reactions occur. Moreover, the characteristic fragmentation pathways of tangeretin were summarized for the subsequent
metabolite identification.

Conclusion:
The analytical method based on UHPLC-Q-Exactive mass spectrometer has the ability to quickly clarify
unknown metabolism. And the the comprehensive metabolism study of tangeretin provided an overall metabolic
profile, which will be of great scientific basis for further studies on tangeretin in determining its pharmacokinetics,
the bioactivity of the metabolites, and clinical applications.
Severe Thromboses in Neonates
Authors: Saxonhouse Matthew A. , Hinson Ashley 
Published: November 2022

Abstract:
Severe thrombosis in the neonate presents a diagnostic challenge to the clinician as the benefits and risks for treatment must be weighed with every medical decision. Aortic thromboses, large right atrial thromboses, and septic thrombophlebitis present unique clinical challenges that must be managed in the appropriate clinical setting with appropriate subspecialty support. Unfortu-nately, there is limited data on what the ideal therapy should be for these specific types of cases. In this review, we will discuss these types of severe thromboses that may occur in neonates and poten-tial therapies that may offer benefits.
Sertraline: Theoretical Studies and a New Potentiometric PVC Membrane
Sensor for its Determination
Authors: Saber Amr L. , Tuzun Burak , Alessa Hussain , Althakafy Jalal T. 
Published: November 2022

Background:
Sertraline (ST) hydrochloride is an anti-depressant of the selective serotonin reuptake inhibitor (SSRI) class. Potentiometric sensors are an appealing route for detecting drugs due to some advantages in terms of sensitivity, feasibility, selectivity, fast response, tolerance to turbidity and colour of solutions, and cost-effectiveness.

Methods:
A mixture of polyvinyl chloride powder (PVC) with o-nitrophenyl octyl ether and the ion association complex was dissolved in tetrahydrofuran (THF) to prepare the membrane for the proposed sensor. The sensor was calibrated and then electrochemically used for detecting ST in pharmaceutical samples.

Results:
The near Nernstian response was observed for a concentration of 1.0 x 10-8 – 1.0 x 10-2 mol L-1 with 58.62 mV as a slope per concentration decade. This direct potentiometric measurement resulted in average recoveries of 96.0 ± 0.2%. Moreover, good selectivity for sertraline with respect to many inorganic and organic cations was observed.

Conclusion:
The proposed sensor was simple to use and produced accurate and precise results. The molecule's chemical and biological activities were revealed using theoretical calculations. Regarding the chemical activities, calculations were made on the 3-21g and 6-31g while the SDD bases were set at B3LYP, HF, and the M062X level. Molecular docking calculations were designed against cancer proteins in order to have details regarding the molecule's biological activity.
Gastric Cancer Derived Mesenchymal Stem Cells Promote the Migration
of Gastric Cancer Cells Through miR-374a-5p
Authors: Ji Runbi , Lin Jiang , Gu Hongbing , Ma Jichun , Fu Min , Zhang Xu 
Published: November 2022

Introduction:
Resident mesenchymal stem cells (MSCs) in the tumor microenvironment play an important role in tumor progression. Up to now, the mechanism of resident MSCs promoting gastric cancer cell migration remains unclear.

Methods:
We tested the migration ability of gastric cancer cells by transwell assays in this study. The inflammatory factors secreted by MSCs were detected by Luminex and ELISA. The activation of NF-κB signaling was detected by western blot. The exosomes derived from MSCs were isolated and identified by transmission electron microscope, nano-sight and western blot. The expression of miR-374a-5p was confirmed by qRT-PCR and its downstream target HAPLN1 by luciferase reporter assay. The expression of adhesion molecules of gastric cancer cells was detected by flow cytometry.

Results:
MiR-374a-5p could regulate the expression of inflammatory factors by activating NF-κB signaling.
The increase of MCP-1 and the decrease of IFN-γ promoted the migration of gastric cancer cells. The
miR-374a-5p in MSCs could be encapsulated and delivered to gastric cancer cells by exosomes derived
from MSCs. Exogenous miR-374a-5p up-regulated the expression of adhesion molecules in gastric cancer
cells by targeting HAPLN1. And miR-374a-5p-enriched exosomes also promoted the migration of gastric
cancer cells.

Conclusion:
MiR-374a-5p promoted gastric cancer metastasis, and resident MSCs in the gastric cancer microenvironment played a major role in the regulation of gastric cancer metastasis. The study will provide new ideas and potential targets for the prevention and treatment of gastric cancer metastasis.
Rural Youth Employability Trends and the COVID-19 Pandemic
Authors: Grinevica Liva , Rivza Baiba , Rivza Peteris 
Published: November 2022

Background:
The COVID-19 pandemic seriously impacts youth employability, especially in rural regions. In rural areas, the lack of system and availability of education, vocational education and training can have a negative impact on a young person's ability to obtain an education and continue to succeed in the labour market. These circumstances can hinder a young person's transition to the labour market.

Aims and Objectives:
The paper presents a brief analysis of rural youth employment trends, the consequences of the COVID-19 pandemic for the labour market in Latvia, and an analysis of the youth employability using dynamic series analysis.

Methods:
The research methodology implemented for the present research study is based on the theoretical concepts and statistical data regarding the rural youth employment trends and the impact of the COVID-19 pandemic.

Results:
Based on the results of the research study, it can be concluded that COVID-19 has contributed to job losses by forcing young people from rural areas to move to a city with better access to employment. The authors have concluded that educated women tend to start their own businesses after graduation, which is positive, especially if it is based in rural areas.

Conclusion:
Based on the authors' calculations, the forecast of employees in the age group from 25 to 34 in Latvia in 2022 is 171.9 thousand, in 2023, it is 156.5 thousand, and in 2024 it is 138.9 thousand. It could be concluded that the projected number of employees in the 25-34 age group will decrease significantly.
Exploring Physical and Non-physical Infrastructure of Bus Rapid Transit and its Connectivity to Intermodal Transport Modes in Semarang
Authors: Rakhmatulloh Anita Ratnasari 
Published: November 2022

Background:
The modern service of public transport system in a developing country is still in the stage of embryo compared to other big cities in the world. Providing reliable and affordable intermodal transportation is a major challenge in Indonesia, particularly in a growing city such as Semarang. The higher volume of traffics in this city leads to critical congestion due to the imbalance between transport infrastructures, mobility management, and travel behaviour. The concept of Bus Rapid Transit was adopted as a transport policy, and it was introduced in Semarang reduce congestion and car dependency as well as to enhance integration of intermodal transport modes. However, there is still a lack of transport infrastructure to support connectivity and integration between Bus Rapid Transit (BRT) and intermodal transportation modes that might influence the willingness to use public transport.

Objective:
The study aims to explore the physical and non-physical facilities to connect between Bus Rapid Transit (BRT) with intermodal transportation modes in Semarang.

Methods:
The research using qualitative method combined with four approaches such as quantitative, phenomenological, literature, and study-case based approaches.

Results:
The research reveals that the intermodal transportation system which employs integration of modes (airport, port, and railway station) improves the efficiency of travel and bus transit experience. Both physical and non-physical public transport amenities are still underrated and there is a need for improvements to make it more reliable, attractive, and easier for transport users (students and non-students). Moreover, the number of transport users dropped dramatically during the COVID-19 pandemic. Furthermore, the lack of public transport infrastructure and amenities results in an inconvenient experience of travel and a decline in the number of bus ridership.

Conclusion:
The local government should creatively improve the physical and non-physical facilities to support Bus Rapid Transit (BRT) services and its connectivity to intermodal transport modes in intercity passengers’ terminals (airport, port and railway stations) in terms of sidewalks, amenities, payment methods, and information system.
Psychometric Evaluation of the Short form of Interpersonal Influences Scale for Stretching Exercise among the Office Employees Based on the of Health Promotion Model in an Iranian Version
Authors: Delshad Mohammad Hossien , Tavafian Sedigheh Sadat , Kazemnejad Anoshirvan , Pourhaji Fatemeh 
Published: November 2022

Background:
Interpersonal influences are critical key points for stretching exercise predicting. In Iran, there's no measure to observe interpersonal Influences amongst workplace office employees.

Objective:
The purpose of this study was to investigate the short form psychometrics of Interpersonal Influences scale for Stretching Exercise predicting among based on Health Promotion Model (HPM) With Added Constructs.

Methods:
By multistage cluster sampling method, this cross-sectional study was done among 385 office employees were selected from the Health networks at Shahid Beheshti University of Medical Sciences of Iran (SBUMS).

Results:
The EFA is shown via the principle component approach one factor with 77% cumulative variance and Kaiser-Mayer-Olkin (KMO) became 90.7%; p -value< 0.001. This was the good fit index in Confirmatory Factor Analysis (CFA). Also With the help of Construct validity, factor was explanted. Within the CFA area, Root Mean Square Error of Approximation (REMSEA) result display= 0.059, Goodness of Fit Index (GFI) = 0.966, Adjusted Goodness of Fit Index (AGFI) = 0.985 confirmed with Cronbach’s alpha (α = 0.834%) and [ (ICC) =0.79 95% Confidence ICCnterval (CI) (0.58, 0.84)].

Conclusion:
This study generated a Persian-language version of the Interpersonal Influences scale among the office employees Based on the of HPM.