bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous analysis of two drugs used as supportive treatment for COVID-19: comparative statistical studies and analytical ecological appraisal
Authors: Ibrahim Hany , El-Abassy Omar M , Abdellatef Hisham Ezzat , Hendawy Hassan A. M. , El-Sayed Heba M 
Published: September 2022

AbstractPharmaceutical quality control products (QC) demand quick, sensitive, and cost-effective methods to ensure high production at a low cost. Green analytical methods are also becoming more common in pharmaceutical research to cut down on the amount of waste that goes into the environment. Meclizine hydrochloride (MZH) and pyridoxine hydrochloride (PYH) are reported to be excellent for calming down COVID-19. As a result, the amount of MZH and PYH manufactured by multinational pharmaceutical organizations has increased considerably during the last several months. The present work proposes three environmentally friendly, straightforward, and sensitive spectrophotometric procedures for quantification of MZH in the presence of PYH in a pure and marketable formulations. The approaches under examination include ratio subtraction (RSM), induced dual wavelength (IDW), and Fourier self-deconvolution (FSD). PYH, on the other hand, was directly quantified at 290 nm. For both drugs, the procedures follow Beer’s law in the range of (5–50 µg/mL). The RSM, IDW, and FSD methods, as well as the zero-order approach for PYH, have all been verified in accordance with ICH standards. The ecological value of established methodologies was determined using four distinct ways: the national environmental methods index (NEMI), the analytical Eco-scale, the Analytical Greenness Metric (AGREE), and the green analytical process index (GAPI). Comparing the findings to those of the previously described spectrophotometric technique, no major changes were identified.
Parasitic strongyle nemabiome communities in wild ruminants in Sweden
Authors: Halvarsson Peter , Baltrušis Paulius , Kjellander Petter , Höglund Johan 
Published: September 2022

Abstract
Background
Wildlife hosts may serve as reservoirs for strongyles, which can be transmitted to domestic livestock. Therefore, studies evaluating nemabiome compositions in wildlife ruminants are of great use in assessing the possibility of transmission of important nematode pathogens to domestic sheep in Sweden.

Methods
First, fecal samples were collected from roe deer (n = 125), fallow deer (n = 106), red deer (n = 18) and mouflon (n = 13) in south central Sweden during the hunting season in 2019. Second, after fecal examination samples were cultured and the larvae were harvested, followed by DNA extractions. Third, all samples were barcoded and processed for sequence analysis on the PacBio platform. Finally, bioinformatic sequence analysis was conducted with DADA2, while species diversity and richness, as well as interactions between the different hosts, were calculated and analyzed in R.

Results
Nematode ITS2 sequences were found in 225 of 262 (86%) samples. In total, 31 taxa were identified, among which 26 (86%) to the species level. These were found in different combinations, among which 24 (77%) occurred in roe deer, 19 (61%) in fallow deer, 20 (65%) in red deer and 10 (32%) in mouflon. Five of the species found are known to be associated with livestock (Chabertia ovina, Haemonchus contortus, Oesophagostomum venulosum, Teladorsagia circumcincta and Trichostrongylus axei). However, in the present study the relative abundance and prevalence of most of these species were low. The most striking exception was T. axei, which was relatively abundant in all wildlife hosts. Mostly a wide range of wildlife specific nematodes such as Ostertagia leptospicularis and Spiculopteragia spp. were identified including the invasive nematode Spiculopteragia houdemeri, which was found for the first time in red deer, fallow deer, and mouflon in Sweden. The difference in the number of shared species between mouflon and all cervids (n = 6) was less than among all three cervids (n = 8).

Conclusion
In this study, we investigated the community structure of parasitic intestinal nematodes in four wildlife hosts, and we found that the majority of the parasite species identified were wildlife specific. We also found a new, potentially invasive species not reported before. After comparing the nemabiome of the wildlife hosts in this study with a previous study in sheep from the same geographical region, we conclude that the horizontal transmission potential appears to be relatively low. Still, cross-infections of nematodes between game and sheep cannot be completely ignored.

Graphical Abstract
Guidance on review type selection for health technology assessments: key factors and considerations for deciding when to conduct a de novo systematic review, an update of a systematic review, or an overview of systematic reviews
Authors: Kim Joanne S. M. , Pollock Michelle , Kaunelis David , Weeks Laura 
Published: September 2022

Abstract
Background
A systematic review (SR) helps us make sense of a body of research while minimizing bias and is routinely conducted to evaluate intervention effects in a health technology assessment (HTA). In addition to the traditional de novo SR, which combines the results of multiple primary studies, there are alternative review types that use systematic methods and leverage existing SRs, namely updates of SRs and overviews of SRs. This paper shares guidance that can be used to select the most appropriate review type to conduct when evaluating intervention effects in an HTA, with a goal to leverage existing SRs and reduce research waste where possible.

Process
We identified key factors and considerations that can inform the process of deciding to conduct one review type over the others to answer a research question and organized them into guidance comprising a summary and a corresponding flowchart. This work consisted of three steps. First, a guidance document was drafted by methodologists from two Canadian HTA agencies based on their experience. Next, the draft guidance was supplemented with a literature review. Lastly, broader feedback from HTA researchers across Canada was sought and incorporated into the final guidance.

Insights
Nine key factors and six considerations were identified to help reviewers select the most appropriate review type to conduct. These fell into one of two categories: the evidentiary needs of the planned review (i.e., to understand the scope, objective, and analytic approach required for the review) and the state of the existing literature (i.e., to know the available literature in terms of its relevance, quality, comprehensiveness, currency, and findings). The accompanying flowchart, which can be used as a decision tool, demonstrates the interdependency between many of the key factors and considerations and aims to balance the potential benefits and challenges of leveraging existing SRs instead of primary study reports.

Conclusions
Selecting the most appropriate review type to conduct when evaluating intervention effects in an HTA requires a myriad of factors to be considered. We hope this guidance adds clarity to the many competing considerations when deciding which review type to conduct and facilitates that decision-making process.
Construction process and development stages of pandemic emotions questionnaire in cancer patients (PEQ-CP)
Authors: Gangeri Laura , Alfieri Sara , Greco Margherita , Bosisio Marco , Petrigliano Rossella , Murru Luciana , Borreani Claudia 
Published: September 2022

Abstract
Background
Despite the numerous tools built ad hoc to investigate the effects of the CoViD-19 pandemic on people, to date there are no known questionnaires that investigate the emotional experiences of cancer patients. This work aims to start a process of construction and validation of a tool that captures these aspects (Pandemic Emotions Questionnaire in Cancer Patients—PEQ-CP).

Method
A mixed method approach was used through three phases, each on a different sample: Phase 1: creation of items and checking of internal validity, through unstructured interviews and verification of the validity of content by "peers" and "experts"; Phase 2: exploration of the factorial structure of the scale through an exploratory factor analysis (EFA); Phase 3: confirmation of the factorial structure of the scale through a confirmatory factor analysis (CFA).

Results
Phase 1 revealed 26 items that can be grouped into 4 theoretical dimensions. "Peers" and "experts" rated all items as understandable and relevant except one, which was reformulated. The EFA in the Phase 2 revealed a factorial structure with 14 items and three dimensions (Emotional Understanding, Communication of Emotions, Feelings the same as others), confirmed by the CFA in Phase 3.

Conclusion
Although further validation steps are required, the PEQ-CP showed good psychometric properties.
Whole genome-wide analysis of DEP family members in sheep (Ovis aries) reveals their potential roles in regulating lactation
Authors: Gai Zhongchao , Hu Songhao , Ma Jun , Wang Yujiao , Gong Guoli , Zhao Jieqiong 
Published: September 2022

Abstract
Background
Sheep milk is an attractive nutritional and functional food source. Some Dishevelled, Egl-10 and pleckstrin (DEP) domain-containing proteins can regulate lactation performance in mammals. However, systematic study of the role of sheep DEP family members in regulating lactation is currently lacking. This study aimed to reveal the roles of sheep DEP family members in lactation by exploring their genetic characteristics and functional features at the whole genome-wide level.

Results
Twenty DEP family members were identified in the sheep genome, and they can be divided into four major groups. Ka/Ks calculations suggest that the purifying selection is the main pressure acting on DEP genes. In the late pregnancy and lactation periods, the expression levels of eight DEP genes exhibited significant differences in the mammary gland. In addition, nutritional conditions have a great influence on the expression of DEP family members, and the DEP gene family underwent more expansion than the average gene family in the early stages of biological evolution. The Mirrortree assays indicated that the DEP family members coevolved in biological evolution.

Conclusions
Our research provides a better understanding of the characters of the DEP domain-containing protein family and their potential roles in regulating lactation in sheep. Moreover, these results of our study may contribute to the genetic improvement of milk performance in dairy sheep breed.

Graphical Abstract
Human-wildlife conflict and community perceptions towards wildlife conservation in and around Wof-Washa Natural State Forest, Ethiopia
Authors: Yazezew Dereje 
Published: September 2022

Abstract
Background
Human-wildlife conflict (HWC) is forecasted to increase globally in the vicinity of protected areas and covers various dimensions. It occurs in several different contexts and involves a range of animal taxonomic groups where the needs and requirements intersect with humans’ needs and development. More often, human-monkey conflict occurs in developing countries and is amongst the main threats to biodiversity conservation in these regions. Grivet monkeys are slender agile monkeys of the genus Cercopithecus. This study was conducted to investigate the status of human grivet monkey conflict and the attitude of local communities towards grivet monkey conservation in and around Wof-Washa Natural State Forest (WWNSF), Ethiopia from September 2017 to May 2018. A questionnaire survey (143 respondents) was used to study the human-grivet monkey conflict and its conservation status.

Results
The majority of respondents (male = 67.1%; female = 74.1%) were not supporting grivet monkey conservation due to the troublesome crop-damaging effect of the animal. Respondents having settlements/farmland nearer to the forest have significantly negative perceptions towards grivet monkey conservation than those far from it. The majority of respondents opined that eradication/relocation of grivet monkeys and financial compensation are the options to mitigate human-grivet monkey conflict. Based on the questionnaire result, 42.5 ± SD 8.68 of respondents in all villages elucidated that the main cause of crop damage by grivet monkeys was habitat degradation.

Conclusion
In the study area, Human-Grivet Monkey Conflict (HGMC) is exacerbated by the encroachment of local communities into the forest area, exploitation of resources that would be used by grivet monkeys, and enhanced crop damage by grivet monkeys. As a result grivet monkeys have been persecuted as a consequence of crop damage. This was due to the negative attitude developed from human perspective. Thus, awareness creation education programs and feasible crop damage prevention techniques need to be implemented.
ESG in the boardroom: evidence from the Malaysian market
Authors: Kamaludin Kamilah , Ibrahim Izani , Sundarasen Sheela , Faizal OVA 
Published: September 2022

AbstractThis study examines the influence of boards’ characteristics with respect to independence, diversity, and diligence on the environment, social, governance (ESG) disclosure among Bursa Malaysia companies. The board characteristics are proxied by the percentage of independent directors, women on the board, and the number of board meetings, respectively. We collected data from all 785 companies listed on the Kuala Lumpur Stock Exchange. Our final sample consisted of 91 companies that have an ESG disclosure score. Using GLS panel regression analysis, our findings overall indicate that board independence and diversity enhance ESG disclosure practice significantly for companies in all sectors. However, board diligence is related negatively to ESG disclosure. As expected, the significance of the relations among the board characteristics and the ESG disclosures are more profound from 2014 onward, largely because of changes in regulatory requirements. Our study provides new understanding and insights pertaining to the importance of board independence and board diversity on ESG initiatives and disclosures in the Malaysian context. This research complements studies in the areas of sustainability and strategy, and contributes to business practices with respect to the composition of boards of directors.
Drive-train torsional vibration suppression of large scale PMSG-based WECS
Authors: Zhou Feihang 
Published: September 2022

AbstractThis paper provides a systematic analysis of the large scale PMSG (permanent magnet synchronous generator)-based WECS (wind energy conversion system) torsional vibration problem under MPPT (maximum power point tracking) control and constant power control. This is from the perspective of SSO (sub-synchronous oscillation), SSH (sub-synchronous harmonics) and forced torsional vibration. The cause of SSO is the negative total system damping, weakened by the constant power control. The system is susceptible to inducing SSH in the grid current and voltage in the under-damped condition. To effectively suppress the torsional vibration of PMSG-based WECS, a stiffness compensation control strategy based on adaptive damping is proposed. The results show that SSO, SSH and the forced torsional vibration can be suppressed at the source using the proposed suppression strategy.
Tricuspidization technique with reimplantation for a bicuspid aortic valve: a case report
Authors: Hohri Yu , Numata Satoshi , Okita Yutaka , Yaku Hitoshi 
Published: September 2022

Abstract

Background
Bicuspid aortic valve (BAV) is the most frequent congenital cardiac anomaly. We report a successful case in which the tricuspidization technique with valve-sparing aortic root replacement was used for BAV with severe aortic regurgitation.

Case presentation
A 22-year-old man was admitted for progressively worsening aortic regurgitation due to a congenital BAV. Preoperative examination revealed annuloaortic ectasia and left ventricular dilatation with worsening ejection fraction. The right and left coronary cusps of the aortic valve were fused with severe prolapse. During surgery, as there was no obvious calcification or degeneration of each coronary cusp and the commissural orientation was nearly 120°, we judged that tricuspid reconstruction was preferable. Neo-left and right commissure reconstruction by raphe suspension and free margin resuspension of the non-coronary cusp were performed with valve-sparing aortic root replacement (reimplantation technique). Postoperatively, the coaptation height of each coronary cusp was remarkably increased, and aortic regurgitation and left ventricular function improved. The patient was discharged 12 days postoperatively without any complications.

Conclusions
The tricuspidization technique with valve-sparing aortic root replacement was a valuable strategy for repairing the bicuspid valve (type I) with severe aortic valve regurgitation. Although we believe that our tricuspidization technique has the potential for good durability, further experience is warranted to confirm the safety and efficacy of this technique.
Importance of gradual induction in oral anticoagulation therapy in a patient with heparin-induced thrombocytopenia with a left ventricular assist device: a case report
Authors: Morimoto Kenichi , Yoshikawa Yasushi , Kishimoto Yuichiro , Onohara Takeshi , Nishimura Motonobu 
Published: September 2022

Abstract

Background
We encountered a case of a patient with heparin-induced thrombocytopenia (HIT) who developed multiple thromboses following implantable left ventricular assist device (iLVAD) implantation. We herein report this case along with a literature-based discussion on the timing of warfarin initiation for such patients.

Case presentation
A 15-year-old boy was rushed to our hospital due to cardiogenic shock associated with multiple organ dysfunction. A detailed examination, including cardiac catheterization and right heart biopsy, provided a diagnosis of dilated cardiomyopathy, for which an iLVAD placement as a bridge to cardiac transplantation was scheduled after the transplant workup. Three days before the surgery, the patient’s platelet count decreased drastically from 110,000 to 40,000/µL, suggesting HIT, and his blood sample was sent to a specialized laboratory outside our hospital. The HIT antibody test came back positive during the iLVAD implantation using heparin. Thus, we chose argatroban over heparin for postoperative anticoagulation therapy, which was initiated 6 h after the surgery. The day after surgery, the patient was successfully weaned off mechanical ventilation and extubated. Oral anticoagulation therapy with warfarin was also initiated; however, on postoperative day 2, contrast-enhanced computed tomography revealed multiple thrombi in the left iliac artery, right iliac vein, and right jugular vein. We suspected hypercoagulation associated with the initiation of warfarin, prompting us to suspend warfarin and continue anticoagulation therapy with argatroban alone. On postoperative day 8, the patient’s platelet count increased to 130,000/µL despite not reaching the normal range and showed two consecutive increases; therefore, we resumed oral warfarin, concerning the efficacy of argatroban as an anticoagulant for iLVAD. Thromboembolism did not recur; the patient was discharged 50 days after the operation and is currently awaiting heart transplantation.

Conclusions
We encountered a case of HIT type II in which multiple thromboses occurred following iLVAD implantation. If HIT antibodies are detected, it is crucial to initiate argatroban monotherapy and wait to start oral anticoagulation therapy with warfarin until platelet count has improved.
Brown to White Fat Transition Overlap With Skeletal Muscle During Development of Larger Mammals: Is it a Coincidence?
Authors: Pani Sunil , Dey Suchanda , Pati Benudhara , Senapati Unmod , Bal Naresh C 
Published: September 2022

Abstract
In mammals, adipose tissues and skeletal muscles (SkMs) play a major role in the regulation of energy homeostasis. Recent studies point to a possibility of dynamic interplay between these 2 sites during development that has pathophysiological implications. Among adipose depots, brown adipose tissue (BAT) is the major energy-utilizing organ with several metabolic features that resemble SkM. Both organs are highly vascularized, innervated, and rich in mitochondria and participate in defining the whole-body metabolic rate. Interestingly, in large mammals BAT depots undergo a striking reduction and concomitant expansion of white adipose tissue (WAT) during postnatal development that shares temporal and molecular overlap with SkM maturation. The correlation between BAT to WAT transition and muscle development is not quite apparent in rodents, the predominantly used animal model. Therefore, the major aim of this article is to highlight this process in mammals with larger body size. The developmental interplay between muscle and BAT is closely intertwined with sexual dimorphism that is greatly influenced by hormones. Recent studies have pointed out that sympathetic inputs also determine the relative recruitment of either of the sites; however, the role of gender in this process has not been studied. Intriguingly, higher BAT content during early postnatal and pubertal periods positively correlates with attainment of better musculature, a key determinant of good health. Further insight into this topic will help in detailing the developmental overlap between the 2 seemingly unrelated tissues (BAT and SkM) and design strategies to target these sites to counter metabolic syndromes.
Anna May Wong and Sessue Hayakawa: Racial Performance, Ornamentalism, and Yellow Voices in Daughter of the Dragon (1931)
Authors: Peng Xin 
Published: September 2022

Abstract
This article provides a comparative study of Anna May Wong and Sessue Hayakawa—the two most iconic stars of Asian descent of American cinema's silent era—by examining the reception history around their rare collaboration, the early sound film and yellow peril thriller Daughter of the Dragon (dir. Lloyd Corrigan, US, 1931). The on-screen collision of these two stars associated with the imaginary East reveals incongruities between a homogeneous Orientalist image and heterogeneous—culturally acquired, professionally trained, mechanically reproduced, and gendered—yellow voices. Situating the star personae of Wong and Hayakawa in the geopolitical environments of the interwar era, the essay foregrounds the plasticity of voice as a form of cultural capital fetishized as an exchangeable commodity through the heavily marketed product of the new sound cinema. In this case study, the accented voice serves also as a contact point between European, American, and Asian film industries. A close analysis of the differently accented yellow voices in Daughter of the Dragon demonstrates the artificial homogeneity of the Orient embodied by the supposedly “authentic” stars of Asian descent and complicates the established configurations of the gendered “Orientals”: the Janus-faced Japanese man and the ornamentalist yellow woman.