bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gestión Administrativa y su impacto en el Plan Anual de Compras de la Universidad Técnica de Babahoyo en 2021
Authors: López Aguilar Washington Patricio , Pérez Arévalo Mario Alejandro 
Published: November 2022

Uno de los principales problemas que surgen al llevar a cabo procesos de contratación en entidades públicas en el Ecuador y especialmente en universidades es la inadecuada gestión administrativa, factores que han afectado los niveles de eficiencia en las adquisiciones que se realizan para el normal y correcto funcionamiento de la institución educativa. En la presente investigación el objetivo principal es analizar la incidencia de la gestión administrativa y su impacto en el plan anual de compras públicas de la Universidad Técnica Estatal de Babahoyo, Para ello se utilizaron métodos analíticos y descriptivos, las técnicas realizadas fueron entrevistas y revisión documental. El resultado de esta información sirvió para identificar la eficiencia y eficacia dentro de los procesos administrativos y especialmente en el área de compras, en la gestión gerencial y en los equipos de trabajo que intervienen en las compras. De acuerdo a los indicadores podemos concluir que la investigación logra un porcentaje alto de eficacia, información que sustenta la incidencia de la gestión administrativa y su impacto en el plan anual de compras es altamente efectivo, se localiza en la escala de Likert entre bueno y excelente, existe relación directa de la gestión administrativa con el grado de cumplimiento del plan anual de compras, el nivel de conocimiento del personal para cumplir con los procesos de compras es alto.
Intervensi Media Gambar Bungkus Rokok dan Perilaku Merokok pada Siswa SMK Negeri di Kota Jambi
Authors: Ridwan Muhammad , Indah Lestari , Sari Puspita 
Published: November 2022

Perilaku merokok dikalangan remaja dibuktikan dengan hasil survey awal di SMK Negeri Kota Jambi terdapat 1020 siswa yang pernah merokok. Penelitian ini bertujuan untuk mengetahui intervensi media gambar bungkus rokok dan perilaku merokok pada siswa SMK Negeri di Kota Jambi Tahun 2021. Jenis penelitian yang digunakan adalah penelitian Quasi Experiment menggunakan rancangan one group pre test post test design dan chi square. Sampel penelitian adalah 102 orang, teknik pengambilan sampel pada penelitian menggunakan proportional random sampling. Penelitian ini menemukan bahwa ada responden perokok aktif 22 responden sedangkan perokok pasif 71 , skor pre- test tingkat pengetahuan tinggi 5, sedang 28, rendah 60 dan skor post-test tingkat pengetahuan kategori tinggi 54, sedang 38, rendah 1 responden. Sedangkan pada variabel sikap, pre-test tingkat sikap kategori baik sebanyak 9 , cukup 59 , kurang 25 responden sedangkan pada skor post-test sikap kategori baik 92 dan cukup 1 responden. perilaku orang tua yang kurang baik 42, yang baik 51 responden, perilaku negatif dari teman sebaya 43, positif 50 responden. Media gambar bungkus rokok mempunyai pengaruh dengan pengetahuan, sikap dengan perilaku merokok pada siswa SMK dan mempunyai hubungan orang tua dan teman sebaya dengan perilaku merokok siswa.
Single-branched stent-graft with on-table fenestration for endovascular repair of primary retrograde type A aortic dissection: A multicenter retrospective study
Authors: Zhang Heng , Feng Jiaxuan , Zhu Hongqiao , Xiao Shun , Liu Mingyuan , Xu Yili , Yang Dongshan , Liu Junjun , Guo Mingjin 
Published: November 2022

ObjectiveThis study aims to evaluate the feasibility, efficacy, and safety of a single-branched stent-graft with on-table fenestration for primary retrograde type A aortic dissection (RTAD) during thoracic endovascular aortic repair (TEVAR).Materials and methodsFrom January 2019 to December 2021, 36 patients with primary RTAD from five tertiary hospitals received medical management in the acute phase. They underwent TEVAR with a proximal zone 1 landing for aortic arch reconstruction in the subacute phase, using a fenestration technique on a single-branched stent-graft. Nearly 2 weeks after admission, computed tomography angiography (CTA) was re-examined to evaluate the thrombosis status of retrograde false lumen (FL). The primary outcomes were technical success, patency of the target branch arteries, and absence of type Ia endoleaks. The second outcomes were stent-graft-related complications and all-cause mortality.ResultsThe mean age was 56.2 ± 11.3 years, and 29 (80.6%) were male. After a median interval of 18.0 [interquartile range (IQR), 17.0–20.3] days of medical treatment, the partial and complete thrombosis of proximal FL rates increased to 52.8% and 47.2%, respectively. One patient (2.8%) experienced postoperative type Ia endoleaks, and was successfully re-treated using coli and Onyx glue. The median hospital stay was 20.5 (IQR, 18.0–23.0) days. The overall technical success rate was 100%. The median follow-up time was 31.5 (IQR, 29.8–34.0) months. There was one death (2.8%) due to gastrointestinal bleeding. Distal aortic segmental enlargement (DASE) occurred in two (5.6%) patients. No major complications or recurrent dissections in the proximal landing zone were recorded during follow up.ConclusionThe retrograde FL in primary RTAD could realize partial or complete thrombosis after medical management in the acute phase, and it might be regarded as a valid proximal landing zone for endovascular repair. The single-branched stent graft with on-table fenestration performed in the subacute phase may be feasible strategy in selective primary RTAD patients.
Case report: Severe dry cough associated with superior vena cava syndrome—Caused recurrent chylothorax
Authors: Wan Ziming 
Published: November 2022

IntroductionSymptomatic pleural effusion is occasionally caused by superior vena cava syndrome. Dyspnea and pleuritic chest pain are common symptoms of pleural effusion. However, the current literature has not reported a causal linkage between chylous pleural effusion and dry cough.Case presentationA patient with uremia suffered from an unexplained severe dry cough, which could be triggered by postural changes. Medical examinations ruled out the possibility of chronic bronchitis, gastroesophageal reflux, chest tumor, tuberculosis, asthma, chronic obstructive pulmonary disease, and allergy history. Examinations showed that the patient had chylous pleural effusion. The cough symptoms were relieved after extraction of the pleural effusion but soon reappeared with the recurrence of chylothorax. Enhanced computed tomography showed that the patient had superior vena cava occlusion. After recanalization of the superior vena cava by percutaneous balloon dilatation, the patient no longer had chylothorax, and the severe cough was eliminated.ConclusionSuper vena cava syndrome can cause chylothorax and further stimulate severe dry cough. Cough is not a specific symptom. Chest imaging and pleural fluid analysis can help narrow down the diagnosis.
Eocene-Oligocene southwest Pacific Ocean paleoceanography new insights from foraminifera chemistry (DSDP site 277, Campbell Plateau)
Authors: Hodel F. , Fériot C. , Dera G. , De Rafélis M. , Lezin C. , Nardin E. , Rouby D. , Aretz M. , Antonio P. , Buatier M. , Steinmann M. , Lacan F. , Jeandel C. , Chavagnac V. 
Published: November 2022

Despite its major role in the Earth’s climate regulation, the evolution of high-latitude ocean dynamics through geological time remains unclear. Around Antarctica, changes in the Southern Ocean (SO) circulation are inferred to be responsible for cooling from the late Eocene and glaciation in the early Oligocene. Here, we present a geochemical study of foraminifera from DSDP Site 277 (Campbell Plateau), to better constrain thermal and redox evolution of the high latitude southwest Pacific Ocean during this time interval. From 56 to 48 Ma, Mg/Ca- and δ18O-paleothermometers indicate high surface and bottom water temperatures (24–26°C and 12–14°C, respectively), while weak negative Ce anomalies indicate poorly oxygenated bottom waters. This is followed by a cooling of ∼4° between 48 and 42 Ma, possibly resulting from a weakening of a proto-EAC (East Australian Current) and concomitant strengthening of a proto-Ross gyre. This paleoceanographic change is associated with better ventilation at Site 277, recorded by an increasing negative Ce anomaly. Once this proto-Ross gyre was fully active, increasing biogenic sedimentation rates and decreasing Subbotina sp. δ13C values indicate enhanced productivity. This resulted in a shoaling of the oxygen penetration in the sediment pile recorded by increasing the foraminiferal U/Ca ratio. The negative Ce anomaly sharply increased two times at ∼35 and ∼31 Ma, indicating enhanced seawater ventilation synchronously with the opening of the Tasmanian and Drake Passage gateways, respectively. The Oligocene glaciation is recorded by a major increase of bottom seawater δ18O during the EOT (Eocene-Oligocene Transition) while Mg/Ca-temperatures remain rather constant. This indicates a significant ice control on the δ18O record.
Environmental and economic assessment of switching from heavy fuel oil to natural gas in industrial boilers and furnaces: Case of Cameroon, a low-income country
Authors: Koumi Ngoh Simon , Epessé Missé Samuel , Moungnutou Mfetoum Inoussah 
Published: November 2022

This paper analyzes the environmental and economic impact of switching fuel in industrial boilers and furnaces. This analysis, performed over 5 years, reveals that the total emissions thus avoided are 85,069 tons of CO2, 17,240 kg of CH4, 4,310 tons of N2O, and 6,630 tons of SOx. The total equivalent CO2 emissions avoided is around 87,802 tons over the decade 2012–2021. Switching results in a significant reduction in greenhouse gases: 17.8% of CO2 emissions, 66.7% of CH4 emissions, and 83.3% of N2O emissions. Analysis conducted at the boiler level shows that CO2 and CO emissions would decrease, respectively, by 2.5% points and 1.05 ppm points when natural gas is used. The same observation is made for SOx and NOx emissions, for which decreases of 188.3 and 236.7 ppm points are recorded. Additionally, the substitution of heavy fuel oil for natural gas enables an increase in thermal efficiency by 3.3% points.
Case Report: Mutations in JAK3 causing severe combined immunodeficiency complicated by disseminated Bacille Calmette–Guérin disease and Pneumocystis pneumonia
Authors: Pan Ying , Pan Hui , Lian Chunan , Wu Beiyan , Lin Jieying , Huang Guang , Cui Binglin 
Published: November 2022

BackgroundAs a form of severe combined immunodeficiency (SCID), Janus kinase 3 (JAK3) deficiency can be fatal during severe infections in children, especially after inoculation of live-attenuated vaccines. We report a unique case of JAK3 deficiency with two compound heterozygous JAK3 mutations complicated by disseminated Bacille Calmette–Guérin (BCG) disease and Pneumocystis pneumonia.Case descriptionA 5-month-old Chinese girl presented with recurring fever and productive cough after BCG vaccination and ineffective antibiotic treatment. Chest CT demonstrated bilateral infiltrations, enlarged mediastinal and axillary lymph nodes, and hypoplasia of the thymus. Mycobacterium tuberculosis and Pneumocystis jirovecii were detected from blood samples by sequencing. Acid-fast bacilli were also found from the sputum aspirate and gastric aspirate. Lymphocyte subset analyses indicated T-B+NK- immunodeficiency, and gene sequencing identified two heterozygous missense mutations (one unreported globally) in the Janus homology 7 (JH7) domain of JAK3. The patient received rifampicin, isoniazid, ethambutol, and trimethoprim/sulfamethoxazole and was discharged after improvements but against advice.OutcomeThe patient died at 13 months of age due to severe infections and hepatic damage.DiscussionSCID should be recognized before inoculation of live-attenuated vaccines in children. Newborn screening for SCID is advocated. Further investigations are needed to better understand the pathogenicity of the variants and molecular mechanism of the JH7 domain of JAK3.
Food falls in the deep northwestern Weddell Sea
Authors: Stauffer Julian B. , Purser Autun , Griffiths Huw J. , Smith Craig R. , Hoving Henk-Jan T. 
Published: November 2022

When pelagic organisms die and fall onto the deep-sea floor they create food falls, i.e., parcels of organic enrichment that subsidize deep benthic scavenging communities. The diversity and quantities of food falls remain unstudied for many ocean regions since they are stochastically deposited and rapidly scavenged. The Southern Ocean habitat supports large populations of megafauna but few food falls have been documented. To investigate the diversity and quantity of food falls in the northwestern Weddell Sea, we analyzed 8476 images from the deep seafloor that were captured during the expedition PS118 on RV Polarstern in 2019 by the camera system OFOBS (Ocean Floor Observation and Bathymetry System). OFOBS was towed 1.5 m above the seafloor along five transects (400 to 2200 m seafloor depth) east of the Antarctic Peninsula. We observed the carcasses of one baleen whale, one penguin, and four fish at depths of 647 m, 613 m, 647 m, 2136 m, 2165 m, and 2112 m, respectively, as well as associated scavenging fauna. To the best of our knowledge, we describe here the first in situ observations of deep-sea food falls for penguins and fish in the Southern Ocean. While the whale carcass seemed in an intermediate successional stage, both the penguin and the fish were likely recently deposited and three of the fish potentially resulted from fishery discards. Our relatively small data set suggests that a diverse array of food falls provide nutrients to the slopes of the Powell Basin.
Transferability of radiomic signatures from experimental to human interstitial lung disease
Authors: Gabryś Hubert S. , Gote-Schniering Janine , Brunner Matthias , Bogowicz Marta , Blüthgen Christian , Frauenfelder Thomas , Guckenberger Matthias , Maurer Britta , Tanadini-Lang Stephanie 
Published: November 2022

BackgroundInterstitial lung disease (ILD) defines a group of parenchymal lung disorders, characterized by fibrosis as their common final pathophysiological stage. To improve diagnosis and treatment of ILD, there is a need for repetitive non-invasive characterization of lung tissue by quantitative parameters. In this study, we investigated whether CT image patterns found in mice with bleomycin induced lung fibrosis can be translated as prognostic factors to human patients diagnosed with ILD.MethodsBleomycin was used to induce lung fibrosis in mice (n_control = 36, n_experimental = 55). The patient cohort consisted of 98 systemic sclerosis (SSc) patients (n_ILD = 65). Radiomic features (n_histogram = 17, n_texture = 137) were extracted from microCT (mice) and HRCT (patients) images. Predictive performance of the models was evaluated with the area under the receiver-operating characteristic curve (AUC). First, predictive performance of individual features was examined and compared between murine and patient data sets. Second, multivariate models predicting ILD were trained on murine data and tested on patient data. Additionally, the models were reoptimized on patient data to reduce the influence of the domain shift on the performance scores.ResultsPredictive power of individual features in terms of AUC was highly correlated between mice and patients (r = 0.86). A model based only on mean image intensity in the lung scored AUC = 0.921 ± 0.048 in mice and AUC = 0.774 (CI95% 0.677-0.859) in patients. The best radiomic model based on three radiomic features scored AUC = 0.994 ± 0.013 in mice and validated with AUC = 0.832 (CI95% 0.745-0.907) in patients. However, reoptimization of the model weights in the patient cohort allowed to increase the model’s performance to AUC = 0.912 ± 0.058.ConclusionRadiomic signatures of experimental ILD derived from microCT scans translated to HRCT of humans with SSc-ILD. We showed that the experimental model of BLM-induced ILD is a promising system to test radiomic models for later application and validation in human cohorts.
Application of Balloon AngioplaSty with the dIstal protection of Stent Retriever (BASIS) technique for acute intracranial artery atherosclerosis-related occlusion
Authors: Yi Ting-yu , Wu Yan-min , Lin Ding-lai , Pan Zhi-nan , Zheng Xiu-fen , Gan Ji , Wu Mei-hua , Lin Xiao-hui , Chen Rong-cheng , Zeng Li-san , Chen Wen-huo 
Published: November 2022

BackgroundEndovascular therapy (EVT) is complex in the context of intracranial atherosclerosis (ICAS)-related large vessel occlusion (LVO) and the re-occlusion rates are high due to residual stenosis, the procedure time is long and the optimal EVT technique is unclear. The Balloon AngioplaSty with the dIstal protection of Stent Retriever (BASIS) technique is a novel thrombectomy technique that allows emergent balloon angioplasty to be performed via the wire of the retrieval stent. Our study presents our initial experience with the BASIS technique in ICAS-related LVO and assesses its feasibility.MethodIn patients with ICAS-related LVO treated with BASIS, clinical and angiographic data were retrospectively analyzed. Angiographic data included first-pass reperfusion (PFR), the rate of residual stenosis, distal emboli, and re-occlusion post-procedure. The Extended Thrombolysis in Cerebral Infarction (eTICI) scale was used to assess reperfusion extent, and an eTICI score ≥2b was defined as successful perfusion. Clinical outcome was evaluated at 3 months (modified Rankin score [mRS]), and an mRS ≤ 2 was defined as a good clinical outcome.ResultsA total of seven patients with ICAS-related LVO were included, and the median age of the patients was 76 years. All patients achieved eTICI 3 reperfusion and FPR. The residual stenosis rate ranged from 5 to 10%. None of the patients had re-occlusion post-procedure. The median puncture-to-reperfusion time was 51 min. None of the patients had a symptomatic cerebral hemorrhage, re-occlusion, distal embolism, and dissection. Good clinical outcomes were observed in four patients (4/7, 57.1%), and 1 patient (1/7, 14.3%) died.ConclusionThe BASIS technique is feasible and safe for treating acute ICAS-related LVO.
Volume and flow modulation strategies to mitigate post-hepatectomy liver failure
Authors: Bell Richard , Begum Saleema , Prasad Raj , Taura Kojiro , Dasari Bobby V. M. 
Published: November 2022

IntroductionPost hepatectomy liver failure is the most common cause of death following major hepatic resections with a perioperative mortality rate between 40% to 60%. Various strategies have been devised to increase the volume and function of future liver remnant (FLR). This study aims to review the strategies used for volume and flow modulation to reduce the incidence of post hepatectomy liver failure.MethodAn electronic search was performed of the MEDLINE, EMBASE and PubMed databases from 2000 to 2022 using the following search strategy “Post hepatectomy liver failure”, “flow modulation”, “small for size flow syndrome”, “portal vein embolization”, “dual vein embolization”, “ALPPS” and “staged hepatectomy” to identify all articles published relating to this topic.ResultsVolume and flow modulation strategies have evolved over time to maximize the volume and function of FLR to mitigate the risk of PHLF. Portal vein with or without hepatic vein embolization/ligation, ALPPS, and staged hepatectomy have resulted in significant hypertrophy and kinetic growth of FLR. Similarly, techniques including portal flow diversion, splenic artery ligation, splenectomy and pharmacological agents like somatostatin and terlipressin are employed to reduce the risk of small for size flow syndrome SFSF syndrome by decreasing portal venous flow and increasing hepatic artery flow at the same time.ConclusionThe current review outlines the various strategies of volume and flow modulation that can be used in isolation or combination in the management of patients at risk of PHLF.
Schwann cells promote the migration and invasion of colorectal cancer cells via the activated NF-κB/IL-8 axis in the tumor microenvironment
Authors: Chen Shuhai , Chen Mingyou 
Published: November 2022

BackgroundEvidence has shown neurons and glial cells were closely related to tumor progression. As the predominant glial cells in the external innervated nerves of the gastrointestinal, the role of Schwann cells (SCs) in colorectal cancer (CRC) has not been well explored.MethodsHCT-116 and HT-29 CRC cells were treated with conditioned medium (CM) from SCs, and the cells’ proliferative and migrating capacities were examined. Cytokine array analysis was used to identify the tumor-promoting-cytokines from SCs-CM. Molecular changes from SCs after being co-cultured with tumor cells were detected by ELISA and reverse transcription-quantitative PCR. The activation of the nuclear factor kappa B (NF-κB) signaling pathway in SCs was demonstrated by immunofluorescence staining. Neutralizing antibody was used to verify the tumor-promoting effects of key cytokine.ResultsMigration and invasion of CRC cells were markedly aided by CM from SCs in vitro. Interleukin-8 (IL-8) was identified as an effective factor. SCs co-cultured with CRC cells upregulated IL-8 expression, which may be related to its activated NF-κB signaling pathway. Neutralization of IL-8 attenuated the tumor-promoting effect of SCs.ConclusionThe present study identified a new mechanism of tumor-neuroglia interaction, enriching the concept of the tumor-neural axis in the tumor microenvironment of CRC, which also inspired potential targets for anti-cancer therapies.
Treatment decision in a 4-year-old-boy with left ventricular outpouching after advanced hemodynamical flow evaluation with 4Dflow CMR: A case report
Authors: Lagerstrand Kerstin , Svensson Par-Arne , Andersson Linnea , Synnergren Mats , Öhman Annika , Petersson Magnus , Sunnegardh Jan , Dangardt Frida 
Published: November 2022

BackgroundThe present study presents a diagnostic course for the characterization of a congenital left ventricular outpouching (LVO) in a 4-year-old boy with severe neonatal heart failure, evaluating the added value of cardiac magnetic resonance (CMR) 4Dflow.Case presentationA boy, born at full term, presented with heart failure immediately after birth. Echocardiography showed dilated left ventricle with poor function and LVO was initially interpreted as an aneurysm. No infection, inflammation, or other cause for heart failure was found. With intensive medical treatment, the heart function returned to normal, and eventually, all medication was terminated. At follow-up, surgical treatment of the LVO was discussed but after CMR 4Dflow, a thorough evaluation of the function of the left ventricle as well as the LVO was possible and the LVO was determined a double-chambered left ventricle with a good prognosis.ConclusionsThe present case demonstrates the clinical usability of CMR 4Dflow for improved decision-making and risk assessment, revealing advanced hemodynamic flow patterns with no need for operation.