bluuebunny/crossref_metadata_2025_split huggingface dataset:
BCL7A‐containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation
Authors: Wischhof Lena , Lee Hang‐Mao , Tutas Janine , Overkott Clemens , Tedt Eileen , Stork Miriam , Peitz Michael , Brüstle Oliver , Ulas Thomas , Händler Kristian , Schultze Joachim L , Ehninger Dan , Nicotera Pierluigi , Salomoni Paolo , Bano Daniele 
Published: October 2022

AbstractMammalian SWI/SNF/BAF chromatin remodeling complexes influence cell lineage determination. While the contribution of these complexes to neural progenitor cell (NPC) proliferation and differentiation has been reported, little is known about the transcriptional profiles that determine neurogenesis or gliogenesis. Here, we report that BCL7A is a modulator of the SWI/SNF/BAF complex that stimulates the genome‐wide occupancy of the ATPase subunit BRG1. We demonstrate that BCL7A is dispensable for SWI/SNF/BAF complex integrity, whereas it is essential to regulate Notch/Wnt pathway signaling and mitochondrial bioenergetics in differentiating NPCs. Pharmacological stimulation of Wnt signaling restores mitochondrial respiration and attenuates the defective neurogenic patterns observed in NPCs lacking BCL7A. Consistently, treatment with an enhancer of mitochondrial biogenesis, pioglitazone, partially restores mitochondrial respiration and stimulates neuronal differentiation of BCL7A‐deficient NPCs. Using conditional BCL7A knockout mice, we reveal that BCL7A expression in NPCs and postmitotic neurons is required for neuronal plasticity and supports behavioral and cognitive performance. Together, our findings define the specific contribution of BCL7A‐containing SWI/SNF/BAF complexes to mitochondria‐driven NPC commitment, thereby providing a better understanding of the cell‐intrinsic transcriptional processes that connect metabolism, neuronal morphogenesis, and cognitive flexibility.
Profile of Students’ Environmental Literacy: A Hypotetic Model to Perform Effective Environmental Education
Authors: Putra Nanda Syah 
Published: October 2022

Environmental literacy is a measurement of the people’s knowledge about environment and its interaction with human life. One of the efforts to achieve environmental literacy is implementing environmental education. The research is focused on efforts to know 1) environmental literacy profile of students in green open space; 2) Hypothetical models for effective environmental learning based on student profile findings. This research is a type of descriptive research. The research subject is students of Junior High School (SMPN) 2 Suayan in the 2020/2021 school year. Total sample is 70 students. Test is used to measure students’ environmental literacy for the domain of knowledge. Non-tests is used to measure attitude and behavior domains. The number of questions/statements is 45 items with 15 questions/ statements for each domain. The average score for environmental literacy for these 3 domains is 77,1 % and is interpreted high. Based on literature and interview, high environmental literacy scores of students are at least influenced by two factors, namely 1) the implementation of environmental education in schools 2) students who are always exposed to green open spaces. Furthermore, based on this result, it is proposed a hypothetical model for the effective implementation of environmental.
The Nitrica I: Funeral deposit of proto-Lusatian warrior from Western Slovakia
Authors: Ondrkál Filip 
Published: October 2022

Abstract
The genesis of Lusatian culture is not sufficiently understood due to the demanding nature of its funeral ideology, which suddenly makes the highest social group invisible in the eyes of archaeologists. The elite proto-Lusatian burial of Nitrica I (Bz C2/D – ca. 1350–1300 BC) points to a persisting warrior-chief component of the Middle Bronze Age origin, which survived here from the previous period and probably contributed to the spread of Lusatian-style pottery. It reveals the diachronic acculturation of ending Tumulus facies, which has retained the habits of depositing votive wealth in graves, while the community of the Urnfield facies have decided (or been forced) to drastically reduce the importance and investment in funeral deposits. Typologically, this is the richest burial of Lusatian cultural zone with a significant continental importance, and offers an excellent case for the integration of multidisciplinary approaches in chronology, sociology, cultural development, and others. Selection of the location of the central burial and its position in the landscape was not accidental, and later began to function as a ritual centre/territorial marker with a high occurrence of metal hoards – which raises several implications in social archaeology and points to a sophisticated spiritual thinking of the Lusatian communities.
Quantitative evaluation and chromatographic fingerprinting for the quality assessment of Pudilan tablet
Authors: Lu Mengya , Tang Qianqian , Zhou Chenyu , Fang Zhizheng , Fan Zheng , Li Xiangyu , Han Rongchun , Tong Xiaohui 
Published: October 2022

AbstractAn easy, quick, and sensitive approach adopting ultra-performance liquid chromatography (UPLC) equipped with diode array detector was used to analyze and systematically evaluate the quality of Pudilan tablets manufactured by 12 distinct pharmaceutical companies. In this research, 15 peaks were chosen as the common peaks to assess the similarities for different batches (S1–S43) of Pudilan tablet samples. In comparison with the control fingerprint, similarity values for 43 batches of samples exceeded 0.922. In addition, by analyzing the reference substances of epigoitrin, caffeic acid, chlorogenic acid, acetylcorynoline, baicalin and baicanshialein, the chromatogram of the 6 reference substances was established. The recoveries for the reference substances which demonstrated good regression in the linear range (r2 > 0.999) were in the range of 98.3–101.1%. The results demonstrated that the established method was highly accurate, efficient and reliable. This study provides a valid, dependable and pragmatic method to evaluate the quality of Pudilan tablet.
Institutions and integration (im)maturity: The case of Bosnia and Herzegovina
Authors: Šiljak Dženita , Nielsen Kristian L. 
Published: October 2022

AbstractIn this paper, we analyze the integration maturity of Bosnia and Herzegovina (BiH) on its path towards EU membership and the role of institutions in the process. Integration maturity focuses on five main parameters for readiness to make integration successful: macroeconomic stability, functioning market economy, competitiveness, access to foreign finance and convergence. We combine a discussion of BiH's readiness on these parameters with insights from institutional economics, and show how inefficient institutions are major obstacles to BiH achieving sustained economic growth and attaining the necessary integration maturity. The main reasons for the institutional deficiencies relate to BiH being an ethnically divided country, but just as much it reflects corruption and elite capture of institutions. Only by thoroughly rethinking and reforming its institutional framework will Bosnia and Herzegovina be able to move forward.
Surface roughness and stainability of new-generation denture base materials after brushing and coffee thermocycling
Authors: Çakmak Gülce , Donmez Mustafa Borga , de Paula Marcella Silva , Akay Canan , Chavan Amit , Schimmel Martin , Yilmaz Burak 
Published: October 2022

AbstractDisk-shaped specimens were prepared from additively (NX and DT), subtractively (MZ), and conventionally manufactured denture base resins (CV). Surface roughness and color coordinates were measured after polishing, simulated brushing, and coffee thermocycling, while surface roughness was also measured before polishing. Polishing reduced the surface roughness of all materials. Brushing and coffee thermocycling increased the surface roughness of only DT. CV had the highest susceptibility to consecutive brushing and coffee thermocycling as it had the highest surface roughness, which was above the clinically acceptable threshold. All materials had similar stainability; only MZ had perceptible color change after brushing. Even though stainability of tested denture base resins was similar, additively or subtractively manufactured computer-aided design and computer-aided manufacturing (CAD-CAM) resins had smoother surfaces after brushing and coffee thermocycling, regardless of the material. Therefore, complete dentures made out of these CAD-CAM resins may have favorable surface properties in the long term.

Graphical abstract
Genetic structure of Anisoptera costata in Southeast Vietnam
Authors: Lan Hong Nguyen Phan , Minh Duc Nguyen , Minh Tam Nguyen 
Published: October 2022

Anisoptera costata is an endangered species in Vietnam, from habitat loss and over-exploitation. To protect this species, we analyzed 56 adult trees using eight microsatellites to investigate the genetic diversity within and among three A. costata populations, representing the range of distribution of this species in southeastern Vietnam. Our results showed low genetic diversity (NA = 2.5, HO = 0.244, HE = 0.268). Genetic population differentiation among populations was low (FST = 0.139), indicating high gene flow (Nm = 2.838). Genetic variation among individuals was 79.77%. These suggest a lack of genetic diversity in A. costata. The clustering analysis also showed two genetic clusters. These results will provide necessary information to improve the efficiency of conservation and management of this species.
Blockade of interleukin-33 activities by recombinant interleukin-33 Trap Fc protein would be a novel therapeutic strategy in allergic asthma
Authors: Thanh Nguyen Thao Thi , Hong Vo Phuc , Dang Nguyen Quan 
Published: October 2022

The majority of autoimmune and allergic diseases are associated with abnormal expression of interleukin (IL)-33, a member of the IL-1 family of cytokines, that function dually as a proinflammatory cytokine and a transcriptional factor. We created an IL-33 inhibitor called "IL-33 Trap Fc" constructed by fusion of an Fc fragment of human immunoglobulin G1 and two distinct extracellular part receptors involved in interacting with IL-33, IL-1 receptors accessory protein, and IL-33 receptor. IL-33 Trap Fc was expressed by two systems, mammalian HEK293 cells and Pichia pastoris yeast. We found that these recombinant proteins were expressed as a glycoprotein and perhaps in dimeric form. IL-33 Trap Fc from HEK293 and P. pastoris suppressed the activity of IL-33 in vitro culture conditions. The glycosylation of IL-33 Trap expressed by P. pastoris yeast was more intensive and heterogeneous than the counterpart protein expressed from HEK293 cells. That is maybe one reason leading to a substantial decrease in the activity of IL-33 Trap Fc from P. pastoris compared with that from HEK293 cells. We also demonstrated that IL-33 Trap Fc expressed from HEK293 cells had therapeutic effects in ovalbumin-induced asthma mouse model. These data collectively suggested that IL-33 Trap Fc potently blocks IL-33 in vitro and in vivo, which may be a novel therapeutic strategy for IL-33-mediated allergic diseases.
Assessing Gender Bias in Paramedic-Provider Patient Handoffs
Authors: Smeltzer Kathryn , Harris Chelsea , Liao Mark , Pettit Katie , Turner Joseph , Sarmiento Elisa 
Published: October 2022

Background/Objective: Gender bias is prevalent in the medical workplace and can lead to burnout. Female providers report higher rates of microaggressions, but studies do not describe direct observation of bias in the workplace. Research shows gender bias in physician evaluations but has not evaluated how gender bias affects communication during patient care. This investigation addresses both limitations by observing whether gender bias impacts paramedic-provider communication. We hypothesize that EMS personnel will preferentially communicate with male Emergency Medicine providers during patient hand-off reports.
Methods: In this study, a blinded observer collected data in real-time while watching interactions between EMS personnel and Emergency Department providers. The observer recorded whether the attending or resident physician received the initial attention and the majority attention of the paramedic and whether the paramedic asked if either the attending or resident physician had questions. Additional questions on the survey regarding EMS communication were documented to keep the observer blinded to the nature of the study. Chi-square analysis was used to determine association between each of four outcomes and provider gender based on four attending-resident groupings (female-female, female-male, male-female, male-male).
Results: Preliminary results of this study show that paramedics preferentially give their first attention and majority of their attention to residents over attendings, regardless of gender. Generally, paramedics did not ask if either attendings or residents had questions. There were no statistically significant differences in likelihood of any of the outcomes based on gender pairings.
Conclusion: Our data do not support the hypothesis that EMS personnel will preferentially communicate with male Emergency Medicine providers during patient hand-offs.
Clinical Impact and Implications: Though gender bias did not affect patient care communication in this study, healthcare workers should be made aware of this potential and educated on how it might appear. Further research should include analyzing gender bias in patient care communication within other medical specialties.
Kebencanaan, Islam, dan Partisipasi Masyarakat: Optimalisasi Destana Donoharjo dan Tim Kamboja Menghadapi Wabah Covid-19
Authors: Widigdo Mohammad Syifa Amin 
Published: October 2022

Artikel yang ditulis berdasarkan kegiatan pengabdian ini bertujuan untuk menggambarkan pentingnya peran serta masyarakat dalam upaya menghadapi Wabah Covid-19. Upaya untuk menanggulangi dan menghadapi Pandemi Covid-19 biasanya dipercayakan kepada pemangku kebijakan publik (pemerintah) untuk membuat instruksi dan para pihak yang ahli dan berkecimpung dalam bidang kesehatan (e.g. dokter, perawat, rumah sakit, puskesmas). Tidak banyak yang memperhatikan kiprah dan peran masyarakat yang sebenarnya tidak bisa disepelekan. Melalui program pengabdian KKN-PPM (Kuliah Kerja Nyata-Pembelajaran Pemberdayaan Masyarakat) UMY, kapasitas dan peran masyarakat dalam menghadapi wabah Covid-19 diperkuat dan digambarkan. Masyarakat dalam hal ini diwakili oleh lembaga yang bernama Destana (Desa Tangguh Bencana) Desa Donoharjo, Ngaglik, Sleman Yogyakarta. Destana Donoharjo yang sedianya dibentuk untuk mitigasi bencana alam, seiring dengan maraknya bencana Wabah Covid-19, lembaga ini juga siaga untuk mencegah maupun menangani bencana wabah yang terus mengganas ini. Selain secara rutin melakukan penyemprotan disinfektan ke tempat-tempat yang potensial menjadi penyebaran virus, Destana juga membentuk Tim Kamboja yang bertugas untuk mengurus jenazah pasien yang terinfeksi Covid-19 hingga ke liang lahat. Keberadaan Tim Kamboja Destana Donoharjo terbukti strategis untuk menjembatani kepentingan keluarga pasien dan ketaatan pada protokol kesehatan yang ditetapkan penyedia layanan kesehatan (healthcare provider).
A retrospective study on the clinical picture of COVID-19 patients associated with type 2 diabetes mellitus in India
Authors: Petimani Mahalaxmi S. , Adake Prabhakar , Halemani Susheela Somappa , Kotian Greeshma B. 
Published: October 2022

Background: The clinical characterization of COVID varies from mild to severe. In the initial phases of the disease, symptoms like fever, cough, and dyspnea can occur. The severity and outcome of COVID vary with preexisting conditions, particularly type 2 diabetes mellitus (T2DM). Objective of current study was to assess the clinical presentation and laboratory derangements of COVID-19 patients associated with T2DM.Methods: The present retrospective study was started after the approval of the Institutional Ethics Committee. Various clinical (Sp02, final diagnosis, co-morbidity, and outcome) and biochemical parameters (CBC, LFT, RFT, LDH, Trop I, CK-MB D-dimer, CRP, ferritin levels, RBS, HbA1c) of Covid-19 patients were collected from Central Laboratory and & Medical Record Department of our institution. Patient names were anonymized and data were analyzed. The results are expressed in percentages.Results: A total of 24 COVID-19 patients (with T2DM) details were collected from the medical record department and central laboratory. Out of 24 patients, 16 (66.6%) were male, and the remaining 08 (33.3%) were female. Out of 24, 05 patients had mild covid, 02 were moderate and the remaining 17 suffered from severe COVID. The mean values of oxygen saturation, LDH, D-dimer, Troponin-I, CRP, Ferritin, Procalcitonin, and CK-MB were 76%, 797.3 U/l, 1614.2 ng/ml, 6.93 ng/ml, 72.6 mg/dl, 521.2 µg/l, 2.33 µg/l and 40.59 ng/ml respectively. The average random blood sugar level and glycosylated hemoglobin were 308.8 mg/dl and HbA1c 10.22%. Mean values of 42.5 mg/dl and 1.54 mg/dl were recorded for blood urea and S. creatinine. Regarding liver function test, mean values of 0.87 mg/dl, 0.37 mg/dl, 0.49mg/dl, 344.8U/l, 115.6U/l,108U/l respectively noted for total bilirubin, direct, indirect, SGOT, SGPT and ALP. Regarding patient outcome, 09 (37.5%) patients recovered and 15 (62.5%) died due to COVID. The values of glycosylated Hb and random blood sugar among the 15 patients who died due to covid infection suggested uncontrolled diabetes Mellitus in 7 of them with associated hypertension and died due to septic shock. Conclusions: Though the laboratory mean values of the liver function test and renal function test shows moderate variations the mean values of CRP, LDH, Procalcitonin, and Ferritin which are the acute inflammatory markers are highly disrupted when compared to normal ranges.
Is antegrade K-wire pinning better than retrograde pinning for distal radius fracture? A comparative study
Authors: Keshava Nischay Kenjige , Gedam Prashant N. , Mhaisane Sahil , Naik Ketan , Dakhode Shubham 
Published: October 2022

<p class="abstract"><strong>Background:</strong> The treatment of distal end radius has undergone tremendous changes over the years due to better understanding of the fracture anatomy, mechanism of injury and development of newer techniques and implants. The objective of treatment of distal end radius fracture is to restore the anatomy and to obtain early function. Percutaneous pinning is a minimally invasive technique to maintain the reduction and prevent re-displacement of the fracture fragments. Sato et al. introduced a technique of fixation for the unstable extra-articular distal radial fractures by manual reduction and antegrade intra-medullary pinning.</p><p class="abstract"><strong>Methods:</strong> A retrospective study with a sample size of 30, where 15 of the selected patients had undergone antegrade fixation and the rest 15 had undergone retrograde fixation.<strong></strong></p><p class="abstract"><strong>Results:</strong> Patients were evaluated for functional and radiological outcomes after a mean follow up of one year. No statistically significant difference was found between the two methods.</p><p class="abstract"><strong>Conclusions:</strong> Both the procedures were effective in managing the distal radius fracture with preservation of fracture hematoma. However soft tissue complications were less in antegrade pinning as compared to retrograde.</p><p class="abstract"> </p>
EU - China relations and data governance policies: the role of civil societies in overcoming geopolitical challenges in cyberspace
Authors: Nalbantoğlu Cem 
Published: October 2022

EU and China are the global powers that can affect and alter international relations at the political, economic, and societal levels. While the EU shapes the foreign policy in Europe, China has a critical role in Asian politics. In Asia-Europe interregionalism and interregional relations, the EU-China relations are essential in consolidating global and regional stability. However, in the current political conjuncture, the security issues in cyberspace challenge both actors. Hence, cybersecurity and digitalization policies are a potential conflict area in EU-China relations. As the impact of technological and digital developments increases on the global political economy, global powers are developing policies to breast the tape in technological development. The European Commission has set “A Europe fit for the digital age” as one of its priorities for the 2019-2024 term. Meanwhile, since 2015 China has been promoting the Digital Belt and Road Initiative to foster digital connectivity among the Belt and Road countries. However, big data analytics are important in developing new technologies, especially in digital connectivity, automation, and robotics. In this context, data governance has become a geopolitical concept in international relations. Consequently, differences between China’s and the EU’s approach to data – access, process, and collection – may result in geopolitical confrontations. In this paper, we argue that both actors should involve civil society in the policymaking process to address the dynamics of information technologies, cooperate on adapting a global approach and avoid geopolitical confrontations. Civil society organizations can help the actors understand the underlying risks in cybersecurity and form a non-conflicting approach in data governance frameworks. Furthermore, while investigating the EU and China’s data governance models, we shed light upon the role of civil society organizations in addressing the potential risks and opportunities in cyberspace. Finally, we conclude our paper with policy recommendations for China and the EU to cooperate in cyberspace by involving civil society organizations.
Received: 18 May 2022Accepted: 25 July 2022
Brief overview of the factual and onto-epistemological developments of the idea of “civil society” in Japan
Authors: Malo Mario 
Published: October 2022

In the context of post-industrial societies, there are few resources left to ordinary citizens to respond to the totalizing logic of systemic dynamics characterized by the expansion of economic and formal subjectivity. Likewise, the damage done to the environment and the increasing incidence of natural disasters, both driven by anthropogenic action, make a more complex response from society necessary and, in turn, pose the need to find collective answers to transnational issues. This global situation leads us to consider how civil society can generate community cohesion, leverage common interest and respond to environmental problems. After several ethnographic investigations focused on social change in Japan, we identified some things that, together with the shocking initial images spread globally after the catastrophe of March 11, 2011 in Tōhoku, have helped us take the pulse of the associative Japanese world. These images highlighted some of the fundamental characteristics of Japanese civil society, contributing to the spread throughout the world of a series of constructs that are as typical of a society socially exemplary as they are culturally totalizing. It might seem the eleven years that have elapsed since the Triple Disaster of March 2011 in Japan have provided us with a broad perspective from which to interpret the dynamics of Japanese civil society and public administration in the face of these events. However, we consider that the analysis of socio-historical developments that embody Euro-Atlantic modernity, with indigenous cultural constructs and with globalization, is essential. For this reason, in this article, from the perspective of intellectual history and historical sociology, we will analyse the adaptability of the concept of civil society in Japan and a whole series of social processes that have been gestating for decades and whose development is brought together in entities of great factual importance for the future.
Received: 31 May 2022Accepted: 25 July 2022