bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable copper oxide/Tragacanth gum bionanocomposites with multi‐purpose catalytic activities on textile
Authors: Kahali Panid , Montazer Majid , Kamali Dolatabadi Mehdi 
Published: June 2022

AbstractIn this study, a bionanocomposites layer was created on polyester textile through the insitu synthesis of copper nanoparticles using copper acetate in an alkaline solution and Tragacanth gum polymer. The chemical structure and surface morphology of samples were studied by XRD, FTIR, XPS, SEM, and EDX patterns. Moreover, the photocatalytic and antibacterial features, cytotoxicity, the release of nanoparticles, color coordinates, water absorption, thermal behavior, and tensile strength of samples were investigated. In addition, the effect of polymer coating on the created properties on the surface of samples was explored. Based on the obtained results, the prepared fabric with copper oxide/Tragacanth gum bionanocomposites created the fairly suitable photo, bio, hydro, and heat‐catalytic activities granting environment safety.
Records, trust, and misinformation: Using birtherism to understand the influence of conspiracy theories on human information interactions
Authors: Donaldson Devan Ray , LeFevre Colin Bradley 
Published: June 2022

AbstractRecords are persistent representations of activities created by partakers, observers, or their authorized proxies. People are generally willing to trust vital records such as birth, death, and marriage certificates. However, conspiracy theories and other misinformation may negatively impact perceptions of such documents, particularly when they are associated with a significant person or event. This paper explores the relationship between archival records and trustworthiness by reporting results of a survey that asked genealogists about their perceptions of 44th U.S. President Barack Obama's birth certificate, which was then at the center of the “birtherism” conspiracy. We found that although most participants perceived the birth certificate as trustworthy, others engaged in a biased review, considering it not trustworthy because of the news and politics surrounding it. These findings suggest that a conspiracy theory can act as a moderating variable that undermines the efficacy of normal or recommended practices and procedures for evaluating online information such as birth certificates. We provide recommendations and propose strategies for archivists to disseminate correct information to counteract the spread of misinformation about the authenticity of vital records, and we discuss future directions for research.
Combustion timing control of HCCI engine based on NNPC and Elman‐NN model under complex conditions
Authors: Zhang Liangbin , Zheng Taixiong , Ma Ying , Li Yongfu , He Ji 
Published: June 2022

AbstractHomogeneous Charge Compression Ignition (HCCI) combines the characteristics of gasoline engine and diesel engine with high thermal efficiency and low emissions. However, since there is no direct initiator of combustion, it is difficult to control the combustion timing in HCCI engines under complex working conditions. In this paper, Neural Network Predictive Control (NNPC) for combustion timing of the HCCI engine is designed and implemented. First, the black box model based on Elman neural network is designed and developed to estimate the combustion timing. The fuel equivalence ratio, intake valve closing timing, intake manifold temperature, intake manifold gas pressure, and engine speed are chosen as the system inputs. Then, a NNPC controller is designed to control combustion timing by controlling the intake valve closing timing. Simulation results show that the Elman neural network black box model is capable of estimating the HCCI engine combustion timing. In addition, regardless of whether the HCCI engine is in constant or complex condition, the designed NNPC controller is capable of keeping the combustion timing within the ideal range. In particular, under New European Driving Cycle (NEDC) working conditions, the maximum overshoot of the controller is 28.95% and the average error is 1.03 crank angle degree. It is concluded that the controller has good adaptability and robustness.
The pathological risk score: A new deep learning‐based signature for predicting survival in cervical cancer
Authors: Chen Chi , Cao Yuye , Li Weili , Liu Zhenyu , Liu Ping , Tian Xin , Sun Caixia , Wang Wuliang , Gao Han , Kang Shan , Wang Shaoguang , Jiang Jingying , Chen Chunlin , Tian Jie 
Published: June 2022

AbstractPurposeTo develop and validate a deep learning‐based pathological risk score (RS) with an aim of predicting patients' prognosis to investigate the potential association between the information within the whole slide image (WSI) and cervical cancer prognosis.MethodsA total of 251 patients with the International Federation of Gynecology and Obstetrics (FIGO) Stage IA1–IIA2 cervical cancer who underwent surgery without any preoperative treatment were enrolled in this study. Both the clinical characteristics and WSI of each patient were collected. To construct a prognosis‐associate RS, high‐dimensional pathological features were extracted using a convolutional neural network with an autoencoder. With the score threshold selected by X‐tile, Kaplan–Meier survival analysis was applied to verify the prediction performance of RS in overall survival (OS) and disease‐free survival (DFS) in both the training and testing datasets, as well as different clinical subgroups.ResultsFor the OS and DFS prediction in the testing cohort, RS showed a Harrell's concordance index of higher than 0.700, while the areas under the curve (AUC) achieved up to 0.800 in the same cohort. Furthermore, Kaplan–Meier survival analysis demonstrated that RS was a potential prognostic factor, even in different datasets or subgroups. It could further distinguish the survival differences after clinicopathological risk stratification.ConclusionIn the present study, we developed an effective signature in cervical cancer for prognosis prediction and patients' stratification in OS and DFS.
Interventions to promote home radon testing: A randomized clinical trial of a smartphone app vs. printed brochures
Authors: Kim Soojung , Chiu Tiffany , Klug Marilyn G. , Schmitz David , Schwartz Gary G. 
Published: June 2022

AbstractRadon is a preventable cause of lung cancer, but the percentage of homes tested for radon is low. We previously developed a smartphone app that informs users about radon and allows them to request a free radon test. Here we conducted a randomized, controlled trial comparing the radon app versus printed brochures on radon knowledge, attitudes, and behaviors, including the proportion of participants requesting radon tests. Participants (N = 138) were undergraduates at a midwestern university. Data were analyzed by t‐tests, general linear models, and logistic regression. App users showed significantly greater increases in radon knowledge (p = 0.010) and self‐efficacy (p < 0.001) and requested tests three times more often than brochure recipients (41.4% vs. 13.2%, p < 0.001). However, the rate of test usage in each condition was low, ~3%. In conclusion, the radon app markedly outperformed brochures in increasing knowledge and requests for radon tests. Future work should focus on methods to increase test usage.
The application of leukocyte‐ and platelet‐rich fibrin (L‐PRF) in maxillary sinus augmentation
Authors: Powell Charles A. , Casarez‐Quintana Alicia , Zellner Jacob , Al‐Bayati Omar , Font Kerri 
Published: June 2022

AbstractBackgroundSince the introduction of sinus augmentation in the 1970s the procedure has been performed with or without biomaterials. Autologous blood products (ABPs) for use in sinus augmentation was first introduced in the 2000s, to aid potentially in bone and soft tissue healing.MethodsThree different applications of leukocyte‐ and platelet‐rich fibrin (L‐PRF) in maxillary sinus augmentation are presented in this case series. In case 1, L‐PRF is used in bilateral sinus augmentation to support placement of implants to support a maxillary hybrid denture. Case 2 highlights the use of L‐PRF in a complication associate with Schneiderian membrane elevation. Case 3 provides histology taken at the time of implant placement 6 months following L‐PRF/xenograft sinus augmentation.ResultsAll cases resulted in the successful placement of dental implants. In case 2, an osseodensification procedure was performed with freeze‐dried bone allograft, which provided an approximate 4 mm of additional vertical height for implant placement. Histology from case 3 at 6 months post sinus augmentation demonstrated the presence of new vital bone in contact with the xenograft.ConclusionTo date, there is only a limited amount of evidence reporting on platelet‐rich fibrin (PRF) or L‐PRF use in maxillary sinus augmentation. Bone gain from either product has ranged from 3.2 to 11.8 mm, with the percentage of newly formed bone reported in case series as 33% ± 5%. Despite the lack of strong evidence, L‐PRF appears to have beneficial effects on bone regeneration when used in sinus augmentation.
Narratives of Neglect in Social Work with Children and Families: The Relationship between Voice and Narrative
Authors: Revell Lisa 
Published: June 2022

AbstractThis article reports findings from a study which sought to offer primacy to the voice of the child, using narrative approaches to encourage children and young people to share their lived experiences of neglect. Using a constructivist approach, this paper explores the relationship between the voice of the child and their narrative of neglect. Drawing on the notion of ‘family narrative’, the discussion examines how children's views are constructed and reconstructed through the process of telling. This research documents that whilst practitioners seek to present the authentic voice of the child, our understanding of ‘voice’ should be problematized to take account of the fact that it is mediated through a number of filters and lenses. By attending to the voice of the child in the context of their narrative, practitioners may move closer to understanding the lived experience of the individual by exploring feelings, motivations and the myriad of factors which may influence how and for what purpose voice is shared. Engagement with the voice of their child in the context of their narrative, facilitates the development of a social work meta‐narrative to inform effective intervention.
Gender Differences in Cumulative Abuse, Bystander Intervention and Long‐Term Effects on Health and Intimate Partner Violence
Authors: Cho Hyunkag , Seon Jisuk , Lee Jungeun Olivia , Son Esther , Yun Sung Hyun , Kwon Ilan 
Published: June 2022

AbstractThis study examines gender differences in cumulative abuse, measured by the Juvenile Victimization Questionnaire, bystander intervention outcomes and survivors' long‐term health, using student survey data from seven universities (N = 4080). By conducting chi‐squared tests, t‐tests and regression analyses, the results show that more female students reported higher cumulative abuse than male students. Survivors of cumulative abuse reported higher intimate partner violence (IPV) victimisation. Female survivors reported poorer mental health, while male survivors were more involved in alcohol and drug use. Most survivors remembered the bystander presence at the incident of abuse as neither helpful nor harmful, which was not significantly different by gender. Findings suggest that campus service providers need to tailor services considering the gendered effects of cumulative abuse on IPV and its long‐term health ramifications to enhance the effectiveness of services for college students.
DPA‐Substituted Carbazole Derivative as a Fluorescent Ligand for G4 DNA
Authors: Wang Ming , Zhang Feng , Luo Yang , Shuo Li , Wang Ming‐Qi 
Published: June 2022

AbstractHerein a conjugated dipicolylamine/carbazole (Car‐DPA) molecule was designed and synthesized to enhance the performance for the application as a G4 fluorescent ligand. This ligand has been found to display distinct and specific fluorescence enhancements in the presence of various G4 DNA structures, but limited with ssDNA or dsDNAs. The detail binding characteristics of the ligand with c‐MYC G4 DNA were investigated by fluorescence, UV/VIS absorption, CD spectroscopy, and molecular docking. The present study demonstrated that Car‐DPA bound to c‐MYC G4s with a two‐step complex formation, in which the binding mode appeared to be end‐stacking. Confocal fluorescence images indicated that ligand Car‐DPA could locate in nucleus, which is quite prominent from the cellular internalization studies.
The relationship between parents' personality traits and leaving unequal bequests to children
Authors: Sommer Matthew , Lim HanNa 
Published: June 2022

AbstractThis study investigated the relationship between the five‐factor model personality traits and parents' intentions to leave unequal bequests to their children. A sample of 1229 was drawn from the 2016 wave of the health and retirement study. As predicted by the study's hypotheses, the results found that conscientiousness was negatively related to unequal bequests, while extraversion was positively related to unequal bequests. Opposite of the study's prediction, however, was a positive relationship between agreeableness and unequal bequests. Although the effect sizes were small, financial planners can easily use these findings to better understand how their clients' personality traits may play a role in their wealth transfer intentions.
Spectroscopic Signature of Dynamical Instability of the Aqueous Complex in the Brown‐Ring Nitrate Test**
Authors: Banerjee Ambar , Coates Michael R. , Odelius Michael 
Published: June 2022

AbstractThe chemistry of the brown‐ring test has been investigated for nearly a century. Though recent studies have focused on solid state structure determination and measurement of spectra, mechanistic details and kinetics, the aspects of solution structure and dynamics remain unknown. We have studied structural fluctuations of the brown‐ring complex in aqueous solution with ab‐initio molecular dynamics simulations, from which we identified that the classically established pseudo‐octahedral [Fe(H2O)5(NO)]2+complex is present along with a square‐pyramidal [Fe(H2O)4(NO)]2+complex. Based on the inability in multi‐reference calculations to reproduce the experimental UV‐vis spectra in aqueous solution by inclusion of thermal fluctuations of the [Fe(H2O)5(NO)]2+complex alone, we propose the existence of an equilibrium between pseudo‐octahedral and square‐pyramidal complexes. Despite challenges in constructing models reproducing the solid‐state UV‐vis spectrum, the advanced spectrum simulation tool motivates us to challenge the established picture of a sole pseudo‐octahedral complex in solution.
Transformations of Strained Three‐Membered Rings a Common, Yet Overlooked, Motif in Heavy‐Atom Tunneling Reactions
Authors: Schleif Tim 
Published: June 2022

AbstractQuantum mechanical tunneling has long been recognized as an important phenomenon when considering transformations dominated by a lightweight hydrogen atom. Tunneling of heavier atoms like carbon, initially dismissed as negligible, has seen a quickly increasing number of computationally predicted and/or experimentally confirmed examples over the last decade, thus highlighting its importance for a wide variety of reactions. However, no common structural motif has been pointed out within these seemingly unconnected examples, strongly limiting the predictability of the impact of heavy‐atom tunneling on a given reaction. This Concept article will provide this perspective and showcase how the recognition of the formation and cleavage of three‐membered rings as common motif can inform the prediction of and research into heavy‐atom tunneling reactions.
Experimental methods in chemical engineering: Hazard and operability analysis—HAZOP
Authors: Mocellin Paolo , De Tommaso Jacopo , Vianello Chiara , Maschio Giuseppe , Saulnier‐Bellemare Thomas , Virla Luis D. , Patience Gregory S. 
Published: June 2022

AbstractHazards and operability analysis (HAZOP) is one of a dozen‐structured Process Hazards Analysis (PHA) methodologies that assess risks associated with operating processes to mitigate their consequences. HAZOP applies to all six stages of process design from discovery to decommissioning. Industry massively adopted PHA methodologies as a consequence of several industrial disasters in the 1970s that increased society's scrutiny of chemical operations. HAZOPs are conducted by multidisciplinary teams that rely on a set of guide words in combination with the system parameters to identify deviations from the design intent. The team discuss the causes and consequences of deviations, and the project owner modifies the process accordingly. It relies on heuristics rather than algorithms, so the formal structure gives practitioners the false sense that the analysis is comprehensive. Academic institutions increasingly apply PHAs to experimental work, but the scope of a HAZOP is often ill‐suited for this environment as it requires dedicated personnel with particular expertise. Here, we outline the essential features of a HAZOP analysis for early career researchers engaging in process development for conditions that include, for example, high temperature, high pressure, toxic compounds (Hg, phosgene, CO), and potentially explosive and flammable mixtures like organic peroxides. Web of Science indexed over 100 000 documents that mention safety in 2021 and assigned 1500 to chemical engineering. A bibliometric analysis grouped them into five clusters: (1) lithium ion batteries and nanoparticles, (2) fire, simulation, and combustion, (3) models, risk, systems, and techniques (including HAZOP), (4) water treatment, and (5) mechanisms and thermal runaway. [Correction added on 01 September 2022, after first online publication: The item number 3 in the preceding sentence was duplicated in the original published article and has been deleted in this version.]
Vildagliptin‐Derived Dipeptidyl Peptidase 9 (DPP9) Inhibitors: Identification of a DPP8/9‐Specific Lead
Authors: Benramdane Siham , De Loose Joni , Beyens Olivier , Van Rymenant Yentl , Vliegen Gwendolyn , Augustyns Koen , De Winter Hans , De Meester Ingrid , Van der Veken Pieter 
Published: June 2022

AbstractVildagliptin is a marketed DPP4 inhibitor, used in the management of type 2 diabetes. The molecule also has notable DPP8/9 affinity, with some preference for DPP9. Therefore, we aimed to use vildagliptin as a starting point for selective DPP8/9 inhibitors, and to engineer out the parent compound's DPP4‐affinity. In addition, we wanted to identify substructures in the obtained molecules that allow their further optimization into inhibitors with maximal DPP9 selectivity. Various 2S‐cyanopyrrolidines and isoindoline were investigated as P1 residues of vildagliptin analogs. The obtained set was expanded with derivatives bearing O‐substituted, N‐(3‐hydroxyadamantyl)glycine moieties at the P2 position. In this way, representatives were discovered with DPP8/9 potencies comparable to the parent molecule, but with overall selectivity towards DPP4, DPP2, FAP, and PREP. Furthermore, the most promising molecules in this series have a 4‐ to 7‐fold preference for DPP9 over DPP8. Finally, a molecular dynamics study was carried out to maximize our insight into experimental selectivity data.
Oxytocin receptors are widely distributed in the prairie vole (Microtus ochrogaster) brain: Relation to social behavior, genetic polymorphisms, and the dopamine system
Authors: Inoue Kiyoshi , Ford Charles L. , Horie Kengo , Young Larry J. 
Published: June 2022

AbstractOxytocin regulates social behavior via direct modulation of neurons, regulation of neural network activity, and interaction with other neurotransmitter systems. The behavioral effects of oxytocin signaling are determined by the species‐specific distribution of brain oxytocin receptors. The socially monogamous prairie vole has been a useful model organism for elucidating the role of oxytocin in social behaviors, including pair bonding, response to social loss, and consoling. However, there has been no comprehensive mapping of oxytocin receptor‐expressing cells throughout the prairie vole brain. Here, we employed a highly sensitive in situ hybridization, RNAscope, to construct an exhaustive, brain‐wide map of oxytocin receptor mRNA‐expressing cells. We found that oxytocin receptor mRNA expression was widespread and diffused throughout the brain, with specific areas displaying a particularly robust expression. Comparing receptor binding with mRNA revealed that regions of the hippocampus and substantia nigra contained oxytocin receptor protein but lacked mRNA, indicating that oxytocin receptors can be transported to distal neuronal processes, consistent with presynaptic oxytocin receptor functions. In the nucleus accumbens, a region involved in oxytocin‐dependent social bonding, oxytocin receptor mRNA expression was detected in both the D1 and D2 dopamine receptor‐expressing subtypes of cells. Furthermore, natural genetic polymorphisms robustly influenced oxytocin receptor expression in both D1 and D2 receptor cell types in the nucleus accumbens. Collectively, our findings further elucidate the extent to which oxytocin signaling is capable of influencing brain‐wide neural activity, responses to social stimuli, and social behavior.Key points
Oxytocin receptor mRNA is diffusely expressed throughout the brain, with strong expression concentrated in certain areas involved in social behavior.
Oxytocin receptor mRNA expression and protein localization are misaligned in some areas, indicating that the receptor protein may be transported to distal processes.
In the nucleus accumbens, oxytocin receptors are expressed on cells expressing both D1 and D2 dopamine receptor subtypes, and the majority of variation in oxytocin receptor expression between animals is attributable to polymorphisms in the oxytocin receptor gene.
Light‐Induced and Thermal Isomerization of Azobenzenes on Immobilized Gold Nanoparticle Aggregates
Authors: Kunfi Attila , Ábrahám Ágnes , Gyulai Gergő , Kiss Éva , London Gábor 
Published: June 2022

AbstractMorphologically different gold nanoparticle (AuNP) aggregates were prepared on macroscopic surfaces covered with a layer of polydopamine (PDA). The extent of particle aggregation and the particle size distribution could be controlled by the Au(III) reduction times, while the reduction process was triggered solely by the redox active polymer. Shorter reaction times led to smaller particles along with lower levels of aggregation, while longer reductions resulted in larger average particle diameter and heavier aggregation. The prepared surfaces were characterized by UV‐Vis, AFM and KPFM techniques. These surfaces were used as solvent‐free condensed phases to probe the photochemical and thermal isomerization processes of attached azobenzenes with different spacer lengths. Fast and reversible light‐induced switching was observed in each case. The thermal cis‐to‐trans isomerization was found to be accelerated for particle‐bound azobenzenes compared to those in solution.