bluuebunny/crossref_metadata_2025_split huggingface dataset:
A quantification method for trace level of oxytocin in food matrices using LC-MS/MS
Authors: Kumar Dinesh , Azad Ramiz M. R. , Oulkar Dasharath , Oberoi Harinder Singh , Jacob Sanu , Koner B. C. , Sonkar S. C. 
Published: December 2022

Backgrounds: Oxytocin is nowadays used to increase the agricultural products besides its use during the milking of cattle leading to the contamination of agricultural produce and milk with oxytocin. Monitoring of accurate oxytocin contaminations from foodstuffs is sometimes required to maintain the quality standard. The commonly used oxytocin assays in this study were interfered with by the food matrix. There is a need to develop an accurate and confirmed method for monitoring oxytocin contaminations in foodstuffs.Objective: An attempt is made to develop an accurate assay method of oxytocin from milk and agricultural produces.Methods: The acidified methanol was used for the extraction of oxytocin from target food stuff/matrices (agricultural produce and Milk). LC-MS/MS was used for its detection and quantification. In the chromatographic separation, Oxytocin concentration was optimized using selective reaction monitoring (SRM) with heated electrospray ionization (HESI) in positive polarity. The chromatographic separation was performed using a reversed-phase C18 column with gradient elution at a flow rate of 0.4 ml/min. The acidified methanol was used for the extraction of oxytocin in all target food matrices. The method performance was verified as per the SANTE 2021 guideline. After method validation, the method was applied in real food samples analysis for assessing the presence/absence of oxytocin.Results: The calibration curve offered excellent linearity (R2 = 0.999) with less than 15% residuals. The matrix effect was &lt;20% observed for all target matrices. The mean recoveries were within 70%–115% with &lt;11% RSD at four different levels in milk and 0.01 mg/kg in fruits and vegetables. The optimized method was applied to 50 random samples of milk, fruits, and vegetables from the market for the purposes of an established quality control approach. Based on the results, we did observe a signal of oxytocin in the random samples Therefore, this method has shown its practical suitability for the detection of oxytocin in milk, fruits, and vegetables.Conclusion: Extraction of oxytocin using acidified methanol followed by assays using LC-MS/MS is a simple, sensitive, accurate, reproducible, and practically suitable method for detection and quantification of oxytocin from milk, fruits, and vegetables.
Substorm activity as a driver of energetic pulsating aurora
Authors: Troyer Riley N. , Jaynes Allison N. , Kaeppler Stephen R. , Varney Roger H. , Reimer Ashton S. , Jones Sarah L. 
Published: December 2022

Pulsating aurora are common diffuse-like aurora. Studies have suggested that they contain higher energy particles than other types and are possibly linked to substorm activity. There has yet to be a quantitative statistical study of the variation in pulsating aurora energy content related to substorms. We analyzed the inverted energy content from 53 events using the Poker Flat Incoherent Scatter Radar. To reduce the uncertainty, we split the differential energy flux into low and high energy using the limit of 30 keV. We also analyzed the lower altitude boundary of the electron density profile, characterized by a number density of >1010 m−3, and used this as a proxy for high energy. We compared both of these to magnetic local time (MLT), AE index, and temporal proximity to substorm onset. There was a slight trend in MLT, but a much stronger one in relation to both substorm onset and AE index. For higher AE and closer to onset the total energy flux and flux above 30 keV increased. In addition, this higher energy remained enhanced for an hour after substorm onset. Our results confirm the high energy nature of pulsating aurora, demonstrate the connection to substorms, and imply their importance to coupling between the magnetosphere and atmosphere.
Single low-dose ketamine infusion for women with prenatal depressive symptoms undergoing cesarean delivery: A pilot randomized trial
Authors: Wang Shuo , Deng Chun-Mei , Zeng Yuan , Ma Jia-Hui , Qu Yuan , Wang Dong-Xin 
Published: December 2022

BackgroundKetamine is approved for antidepressant therapy, but evidence regarding its use in women with perinatal depression is lacking. Herein, we investigated the effects of low-dose ketamine in women with prenatal depressive symptoms and tested the feasibility of a future large randomized trial.MethodsThis was a randomized, double-blind, placebo-controlled pilot trial. Sixty-six women with prenatal depressive symptoms who were scheduled for elective cesarean delivery were randomized to receive either low-dose ketamine (0.5 mg/kg) or placebo (normal saline). The study drugs were intravenously infused over a 40-minute period after clamping the umbilical cord. The primary outcome was depression score assessed with the Edinburgh Postnatal Depression Scale at 48 h postpartum. Among other and safety outcomes, occurrence of nausea or vomiting was observed, pain intensity was assessed with the numeric rating scale. The feasibility of implementing the protocol was also evaluated.ResultsA total of 64 parturients were included in the intention-to-treat analysis. The depression score at 48 h did not differ between groups: median 9 (interquartile range 6 to 13) with ketamine vs. 8 (6 to 10) with placebo; median difference 1, 95% CI −1 to 3; P = 0.608. The pain intensity at 4 h postpartum was less severe in the ketamine group (median difference −1, 95% CI −1 to 0, P = 0.002). Among safety outcomes, intraoperative nausea or vomiting was less common in patients given ketamine (0.0% [0/33] with ketamine vs. 21.2% [7/33] with placebo, P = 0.011). Recruitment was satisfactory and the protocol was acceptable to participants and clinicians.ConclusionsA single low-dose ketamine infusion did not decrease the depression score at 2 days, but reduced intraoperative nausea and vomiting and lowered pain intensity at 4 h after cesarean delivery among women with prenatal depressive symptoms. The study protocol is feasible for a large randomized trial.Clinical Trial RegistrationThe study was registered with ClinicalTrials.gov (identifier: NCT03336541; 08/11/2017).
D-lactate is a promising biomarker for the diagnosis of periprosthetic joint infection
Authors: Fuchs M. , Faschingbauer M. , Riklin-Dold M. , Morovic P. , Reichel H. , Trampuz A. , Karbysheva S. 
Published: December 2022

IntroductionReliable biomarkers for the diagnosis of periprosthetic joint infection (PJI) are of paramount clinical value. To date, synovial fluid leukocyte count is the standard surrogate parameter indicating PJI. As D-lactate is almost solely produced by bacteria, it represents a promising molecule in the diagnostic workflow of PJI evaluation. Therefore, the purpose of this study was to assess the performance of synovial fluid D-lactate for diagnosing PJI of the hip and knee.Materials and MethodsThese are preliminary results of a prospective multicenter study from one academic center. Seventy-two consecutive patients after total hip arthroplasty (THA) or total knee arthroplasty (TKA) were prospectively included. All patients received a joint aspiration in order to rule out or confirm PJI, which was diagnosed according to previously published institutional criteria. Synovial fluid D-lactate was determined spectrophotometrically at 450 nm. Receiver operating characteristic (ROC) analysis was performed to assess the diagnostic performance.ResultsEighteen patients (25%) were diagnosed with PJI and 54 patients (75%) were classified as aseptic. Synovial fluid D-lactate showed a sensitivity of 90.7% (95% CI: 79.7%–96.9%) and specificity of 83.3% (95% CI: 58.6%–96.4%) at a cut-off of 0.04 mmol/L. The median concentration of D-lactate was significantly higher in patients with PJI than in those with aseptic conditions (0.048 mmol/L, range, 0.026–0.076 mmol/L vs. 0.024 mmol/L, range, 0.003–0.058 mmol/L, p &lt; 0.0001). The predominat microogranisms were staphylococci, followed by streptococci and gram-negative bacteria.ConclusionD-lactate bears a strong potential to act as a valuable biomarker for diagnosing PJI of the hip and knee. In our study, a cutoff of 0.04 mmol/L showed a comparable sensitivity to synovial fluid leukocyte count. However, its specificity was higher compared to conventional diagnostic tools. The additional advantages of D-lactate testing are requirement of low synovial fluid volume, short turnaround time and low cost.
A Narrative Review of Innovative Responses During the COVID-19 Pandemic in 2020
Authors: Wu Tzu-Chi , Ho Chien-Ta Bruce 
Published: December 2022

Objectives: The coronavirus disease 2019 (COVID-19) pandemic presented unprecedented challenges to healthcare systems worldwide. While existing studies on innovation have typically focused on technology, health providers still only have a vague understanding of the features of emergency responses during resource exhaustion in the early stage of a pandemic. Thus, a better understanding of innovative responses by healthcare systems during a crisis is urgently needed.Methods: Using content analysis, this narrative review examined articles on innovative responses during the COVID-19 pandemic that were published in 2020.Results: A total of 613 statements about innovative responses were identified from 296 articles and were grouped under the following thematic categories: medical care (n = 273), workforce education (n = 144), COVID-19 surveillance (n = 84), medical equipment (n = 59), prediction and management (n = 34), and governance (n = 19). From the four types of innovative responses extracted, technological innovation was identified as the major type of innovation during the COVID-19 pandemic, followed by process innovations, frugal innovation, and repurposing.Conclusion: Our review provides insights into the features, types, and evolution of innovative responses during the COVID-19 pandemic. This review can help health providers and society show better and quicker responses in resource-constrained conditions in future pandemics.
Antimicrobial Resistance Surveillance of Tigecycline-Resistant Strains Isolated from Herbivores in Northwest China
Authors: Yu Yongfeng , Shao Changchun , Gong Xiaowei , Quan Heng , Liu Donghui , Chen Qiwei , Chu Yuefeng 
Published: December 2022

There is no doubt that antimicrobial resistance (AMR) is a global threat to public health and safety, regardless of whether it’s caused by people or natural transmission. This study aimed to investigate the genetic characteristics and variations of tigecycline-resistant Gram-negative isolates from herbivores in northwest China. In this study, a total of 300 samples were collected from various provinces in northwest China, and 11 strains (3.67%) of tigecycline-resistant bacteria were obtained. In addition, bacterial identification and antibiotic susceptibility testing against 14 antibiotics were performed. All isolates were multiple drug-resistant (MDR) and resistant to more than three kinds of antibiotics. Using an Illumina MiSeq platform, 11 tigecycline-resistant isolates were sequenced using whole genome sequencing (WGS). The assembled draft genomes were annotated, and then sequences were blasted against the AMR gene database and virulence factor database. Several resistance genes mediating drug resistance were detected by WGS, including fluoroquinolone resistance genes (gyrA_S83L, gyrA_D87N, S83L, parC_S80I, and gyrB_S463A), fosfomycin resistance genes (GlpT_E448K and UhpT_E350Q), beta-lactam resistance genes (FtsI_D350N and S357N), and the tigecycline resistance gene (tetR N/A). Furthermore, there were five kinds of chromosomally encoded genetic systems that confer MDR (MarR_Y137H, G103S, MarR_N/A, SoxR_N/A, SoxS_N/A, AcrR N/A, and MexZ_K127E). A comprehensive analysis of MDR strains derived from WGS was used to detect variable antimicrobial resistance genes and their precise mechanisms of resistance. In addition, we found a novel ST type of Escherichia coli (ST13667) and a newly discovered point mutation (K127E) in the MexZ gene of Pseudomonas aeruginosa. WGS plays a crucial role in AMR control, prevention strategies, as well as multifaceted intervention strategies.
METODE MENGHAFAL NADZOM CEPAT
Authors: Ulum Bahrul 
Published: December 2022

Pondok Pesantren salaf until now consistently used memorizing technique to learn Nadzom. This technique becomes one of learning methods for santri. Memorizing Nadzom certainly need particular method in order to let santri or students frequently mastering the Nadzom in certain time. At this stage, memorizing technique intensively can be primary reference. But, before applying this technique to the students, teachers shall start it with proper preparation. One of those preparation can be let the student absorb the motivation that memorizing is an easy task. Memorizing the Nadzom is one of steps should be fulfilled by santri to learn about Arabic grammatical language. Because within those Nadzom, the key words of grammatical lie on.
Key words: memorizing technique, Nadzom, learning method, santri, pesantren.
Pembelajaran Daring: Perkembangan (Efektivitas dan Kekurangan) di Masa Pandemi Covid19
Authors: Arif Fathul , Kaharuddin  , Muhammad Irwan  
Published: December 2022

Pendidikan dari zaman ke zaman selalu mengalami perubahan, Kemajuan teknogi menjadi andil terbesar dalam perubahan ini. Pada hakikatnya kehadiran teknologi bertujuan untuk memudahkan aktifitas manusia baik dibidang sosial, ekonomi, maupun pendidikan. Penggunaan teknolgi dalam pendidikan telah banyak dilakukan oleh tenaga pendidik, tak lain halnya para guru dan dosen. Ketersediaan aplikasi yang beragam menjadikan guru lebih mudah dalam mendesain pembelajaran. Kehadiran Covid19 tentunya menjadi keresahan bagi masyarakat, sehingga penggunaan teknologi dalam pembelajaran menjadi alternatif yang tepat, namun tentu akan menambah persoalan baru.
İlliberalizmin Yükselişi: Sosyal Medya ve Demokrasi
Authors: ASLAN Mesut 
Published: December 2022

Liberalizm ve demokrasi gibi sosyal olgular tarihsel süreçte sürekli bir değişim içerisinde olmuştur. Günümüzün liberal demokratik rejimleri internet ve sosyal medya gibi güncel teknolojik gelişmelerle başa çıkmakta zorlanmaktadır. Çağımızda uluslararası sistemde en yaygın rejim türü demokrasidir. Ancak yaygınlaşan demokrasi son yıllarda derinliğini yitirmekte ve liberal değerler sistem genelinde gerileme eğilimi göstermektedir. Bu eğilim, illiberalizm olarak ifade edilen ve liberal değerlerin görece göz ardı edildiği demokratik rejimlerin son yıllardaki yükselişini göstermektedir. Liberal demokrasi için olumlu kabul edilen iletişim ve medya alanında yaşanan teknolojik gelişmelere rağmen son yıllarda söz konusu değerlerin gerilemekte oluşu farklı bir bakış açısından açıklama gerektirmektedir. Bu bağlamda internet ve sosyal medya gibi araçların liberal demokrasiye doğrudan katkı sunan araçlar olmadığı argümanı güç kazanmaktadır. Liberal değerlere ilişkin çeşitli veri tabanları üzerinden yapılan değerlendirmelerle gerileme eğilimini ortaya koyan bu çalışma, ayrıca söz konusu gerilemede internet ve sosyal medya gibi çağımızın modern iletişim ve medya araçlarının rolünü açıklamayı amaçlamaktadır.
CONSEQUENCES OF INVALIDATION OF THE WIL
Authors: Алеева Светлана Сергеевна 
Published: December 2022

Последствия недействительности завещания, в отличие от иных сделок, в том числе односторонних, обладают рядом особенностей, которые существуют в силу специфики самой правовой природы завещания и условиями вступления его в законную силу.
The consequences of the invalidity of a will, unlike other transactions, including unilateral ones, have a number of features that exist due to the specifics of the very legal nature of the will and the conditions for its entry into force.
PECULIARITIES OF VOLUNTARY ATTENTION AND INVOLUNTARY ATTENTION IN PATIENTS WITH BIPOLAR AFFECTIVE DISORDER
Authors: Климова Александра Андреевна , Сергиенко Алексей Анатольевич 
Published: December 2022

Исследование посвящено изучению особенностей произвольного и непроизвольного внимания у больных биполярным аффективным расстройством (БАР). Выявлено, что одними из ведущих когнитивных нарушений при БАР являются нарушение произвольного и непроизвольного внимания, трудности включения в программу деятельности в связи с нарушением произвольного внимания. Для разных фаз течения БАР (депрессия, гипомания, фаза смешанного состояния) характерен свой набор дефицитарности нейропсихологических факторов, входящих в состав управляющих функций.
The study is devoted to the study of the features of voluntary and involuntary attention in patients with bipolar affective disorder (BAD). It was revealed that one of the leading cognitive impairments in bipolar disorder is a violation of voluntary and involuntary attention, difficulties in inclusion in the program of activities due to a violation of voluntary attention. Different phases of the course of BAD (depression, hypomania, phase of a mixed state) are characterized by their own set of deficits in neuropsychological factors that are part of the executive functions.
THE INFLUENCE OF THE AUTHOR'S METHOD OF VIBROACOUSTIC MASSAGE BY SINGING BOWLS ON THE PHYSICOCHEMICAL PROPERTIES OF WATER
Authors: Огуй Виктор Олегович 
Published: December 2022

Виброакустические колебания способны вызывать множественные эффекты при воздействии на биологические объекты, и в их основе могут лежать меняющиеся свойства воды. Целью настоящей работы стало исследование изменений электропроводности и кислотности (рН) чистой дистиллированной воды в ответ на воздействие авторским методом виброакустического массажа поющими чашами. Результаты исследования показывают, что виброакустическое воздействие с использованием поющих чаш приводило к достоверному повышению значений кислотности (pH) и электропроводности дистиллированной воды по сравнению с контрольным образцом (p < 0,05).
Vibroacoustic vibrations can cause multiple effects when exposed to biological objects, and they can be based on the changing properties of water. The aim of this work was to study changes in electrical conductivity and acidity (pH) of pure distilled water in response to the influence of the author&#39;s method of vibroacoustic massage by singing bowls. The results of the study show that vibroacoustic exposure using singing bowls led to a significant increase in the acidity (pH) and electrical conductivity of distilled water compared to the control sample (p < 0,05).
CYBERTERRORISM IN THE LATIN AMERICAN REGION: HISTORY AND ANTECEDENTS
Authors: Бочарова Анна Владимировна 
Published: December 2022

В настоящей статье представлена исследовательская концепция изучения проблемы кибертерроризма и кибербезопасности в странах Латинской Америки. Особое внимание акцентируется на исторической стороне вопроса поддержания устойчивого функционирования безопасной информационной среды в регионе.
This article presents a research investigation of the problem of cyberterrorism and cybersecurity in Latin America. Particular attention is focused on issue of the historical antecedents and the ways of maintaining the sustainable functioning of the Cyberspace in the region.
FEATURES OF DEVELOPING A METHOD FOR IMAGE PROCESSING USING CASCADE CLASSIFIERS
Authors: Чирков Андрей Владимирович , Гагарина Лариса Геннадьевна 
Published: December 2022

В работе предложен метод для обнаружения и распознавания болезней растений при снижении энергопотребления посредством использования интегрального представления кадра, каскадов Хаара, перевода изображения в чёрно-белое с дальнейшим обучением классификаторов на обучающих выборках и отбором результирующего каскада.
The paper proposes a method for the detection and recognition of plant diseases while reducing energy consumption by using the integral representation of the frame, Haar cascades, converting the image to black and white with further training of classifiers on training samples and selecting the resulting cascade.
AGREEMENTS BETWEEN THE RUSSIAN FEDERATION AND FOREIGN STATES ON THE ARRANGEMENT OF ISSUES OF DUAL CITIZENSHIP: CURRENT STATUS AND DIRECTIONS OF IMPROVEMENT
Authors: Довгополов Егор Юрьевич 
Published: December 2022

В статье рассматриваются международные договоры, заключенные Российской Федерацией с иностранными государствами, посвященные урегулированию вопросов двойного гражданства. Дается характеристика этих договоров. Предлагаются направления совершенствования межгосударственного правового регулирования отношений двойного гражданства.
The article deals with international agreements concluded by the Russian Federation with foreign states, dedicated to the settlement of issues of dual citizenship. The characteristic of these agreements is given. Directions for improving the interstate legal regulation of dual citizenship relations are proposed.
APPLICATION OF ART THERAPY IN CONDITIONS OF DIGITALIZATION OF THE EDUCATIONAL PROCESS
Authors: Филатова Анастасия Александровна , Козленко Елена Ивановна 
Published: December 2022

Арт-терапия - это область, которая использует невербальный язык искусства для развития личности в качестве средства, дающего возможность контактировать с глубинными аспектами нашей духовной жизни, с внутренней реальностью, складывающейся из наших мыслей, чувств, восприятий и жизненного опыта. Арт-терапия основывается на том, что художественные образы способны помочь в процессах рефлексии.
Art therapy is a field that uses the non-verbal language of art for personal development as a means of getting in touch with the deeper aspects of our spiritual life, with the inner reality that is made up of our thoughts, feelings, perceptions and life experiences. Art therapy is based on the fact that artistic images can help in the processes of reflection.
INCREASING HEALTH WITHIN NUTRITION
Authors: Филатова Анастасия Александровна , Козленко Елена Ивановна 
Published: December 2022

Система питания - достаточно широкое понятие, используемое для описания комплексного процесса, включающего выбор пищи, оценку и расчет ее питательной и энергетической ценности, поступление в организм и последующих ее превращений, включая метаболизм и выведение. Нутрициология подходит к питанию комплексно, углубляясь в состав и качество продуктов. Это наука о питании во всех его аспектах: от химии, биологии, молекул и клеток.
The nutrition system is a fairly broad concept used to describe a complex process that includes food selection, assessment and calculation of its nutritional and energy value, intake and subsequent transformations, including metabolism and excretion. Nutriciology approaches nutrition in a complex way, delving into the composition and quality of products. It is the science of nutrition in all its aspects: from chemistry, biology, molecules and cells.
THE PREVALENCE OF THE ILE462VAL POLYMORPHISM OF THE CYP1A1 GENE AMONG MEN WITH INFERTILITY IN THE UZBEK POPULATION
Authors: Иргашев Дильмурад Саатович 
Published: December 2022

Существенным фактором, формирования мужского бесплодия с позиций доказательной медицины, являются нарушения в системе генов детоксикации ксенобиотиков. Проведен анализ роли полиморфизма Ile462Val гена CYP1A1 в формировании мужского бесплодия. Полученные результаты исследования косвенно указывают на дисрегуляторное влияние неблагоприятного аллельного варианта данного полиморфизма на экспрессию цитохрома CYP1A1.
An essential factor in the formation of male infertility from the standpoint of evidence-based medicine are disorders in the system of xenobiotic detoxification genes. The role of the Ile462Val polymorphism of the CYP1A1 gene in the formation of male infertility was analyzed. The obtained results of the study indirectly indicate the dysregulatory effect of the unfavorable allelic variant of this polymorphism on the expression of cytochrome CYP1A1.