bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential and challenges for using neuroscientific tools in strategic management studies
Authors: Radtke Caneppele Nairana , Ribeiro Serra Fernando Antonio , Contreras Pinochet Luis Hernan , Ramos Ribeiro Izabela Martina 
Published: April 2022

Purpose
The purpose of this study is to understand how neuroscientific tools are used and discussed in ongoing research on strategy in organizations.

Design/methodology/approach
The authors used a bibliometric study of bibliographic pairing to answer the research question. They collected data from the Web of Science and Scopus databases using the keywords “neuroscience*,” “neurostrategy*” and “neuroscientific*.”

Findings
This study presents a framework that relates fundamental aspects discussed in current research using neuroscientific tools: Neuroscience and its research tools in organizations; emotions and information processing; interdisciplinary application of neuroscientific tools; and moral and ethical influences in the leaders' decision-making process.

Research limitations/implications
The inclusion of neuroscientific tools in Strategic Management research is still under development. There are criticisms and challenges related to the limitations and potential to support future research.

Practical implications
Despite recognizing the potential of neuroscientific tools in the mind and brain relationship, this study suggests that at this stage, because of criticisms and challenges, they should be used as support and in addition to other traditional research techniques to assess constructs and mechanisms related to strategic decisions and choices in organizations.

Social implications
Neuroscientific methods in organizational studies can provide insights into individual reactions to ethical issues and raise challenging normative questions about the nature of moral responsibility, autonomy, intention and free will, offering multiple perspectives in the field of business ethics.

Originality/value
In addition to presenting the potential and challenges of using scientific tools in strategic management studies, this study helps create methodological paths for studies in strategic management.
Experimental assessment of thermal gradients and layout effects on the mechanical performance of components manufactured by fused deposition modeling
Authors: Mantecón Ramiro , Rufo-Martín Celia , Castellanos Rodrigo , Diaz-Alvarez José 
Published: April 2022

Purpose
Fused deposition modeling (FDM) is booming as a manufacturing technique in several industrial fields because of its ease of use, the simple-to-meet requirements for its machinery and the possibility to manufacture individual specimens cost-effectively. However, there are still large variations in the mechanical properties of the prints dependent on the process parameters, and there are many discrepancies in the literature as to which are the optimal parameters.

Design/methodology/approach
In this paper, thermal evolution of the printed specimens is set as the main focus and some phenomena that affect this evolution are explored to differentiate their effects on the mechanical properties in FDM. Interlayer waiting times, the thermal effects of the position of the extruder relative to the specimens and the printing layout are assessed. Thermal measurements are acquired during deposition and tensile tests are performed on the specimens, correlating the mechanical behavior with the thermal evolution during printing.

Findings
Additional waiting times do not present significant differences in the prints. Thermal stabilization of the material is observed to be faster than whole layer deposition. The layout is seen to affect the thermal gradients in the printed specimens and increase the fragility. Strain at breakage variations up to 64% are found depending on the layout.

Originality/value
This study opens new research and technological discussions on the optimal settings for the manufacturing of high-performance mechanical components with FDM through the study of the thermal gradients generated in the printed specimens.
Sustainable supervisory relationships between postgraduate international students and supervisors: a qualitative exploration at a Malaysian research university
Authors: Nachatar Singh Jasvir Kaur 
Published: April 2022

Purpose
This paper aims to investigate the perceived sustainable supervisory relationships between supervisors and postgraduate international students at a research university in Malaysia.

Design/methodology/approach
Drawing on a qualitative study based on semi-structured interviews with 33 international postgraduate students and 10 academic staff at a Malaysian research university.

Findings
Perceived sustainable supervisory relationships were perceived by both stakeholders in terms of future employment rapport, further research collaborations upon graduation and global engagement via networking initiatives.

Originality/value
This paper contributes to the supervision literature by establishing novel nuances in the nature and lived experiences of the sustainable supervisory relationships beyond graduation. The implications of developing significant and profound relationships beyond graduation at micro and macro levels are also discussed.
How can aspects of quality of life be incorporated into corporate social responsibility strategies to achieve work life balance?
Authors: Zheng Jenny 
Published: April 2022

PurposeEmployees in the hospitality industry have to adapt to a fast-paced and rapidly changing environment. Furthermore, employees must be able to handle a high volume of work and be willing to work long hours. In this context, the question is how can people work and cope with the pressures of hospitality businesses and at the same time, improve their QoL?Design/methodology/approachOutlines the various theories of corporate social responsibility (CSR) and reviews the meaning of the term quality of life (QoL). Thereafter, the article analyses three examples of hospitality companies (Radisson, Scandic and Peninsula Hotels) that have implemented CSR practices and the extent to which they align with the dimensions of QoL.FindingsConcludes that well-conceived, multidimensional corporate social responsibility (CSR) strategies, combined with transparent reporting tend to enhance employee job satisfaction and quality of work life (QWL). It draws on the literature and case study examples from three companies with a reputation for sustainable thinking and practice.Originality/valueCurrently the links between CSR, QWL and QoL are not well understood, nor the role of CSR initiatives in achieving QoL outcomes and so the paper adds value by providing an explanation of QoL, CSR linked to case study examples.
Using physiological conditions to assess current and future habitat use of a Subarctic frog
Authors: HASTINGS Thomas P. , HOSSACK Blake R. , FISHBACK LeeAnn , DAVENPORT Jon M. 
Published: April 2022

AbstractSpecies with especially close dependence on the environment to meet physiological requirements, such as ectotherms, are highly susceptible to the impacts of climate change. Climate change is occurring rapidly in the Subarctic and Arctic, but there is limited knowledge on ectotherm physiology in these landscapes. We investigated how environmental conditions and habitat characteristics influence the physiological conditions and habitat use of wood frogs (Rana sylvatica) in a Subarctic landscape near Churchill, Manitoba (Canada). We used plaster models to estimate water loss rates and surface body temperatures among different habitat types and at specific locations used by radio‐tracked frogs. Water loss (R2= 0.67) and surface temperature (R2= 0.80) of plaster models was similar to that of live frogs. Model‐based water loss rates were greater in tundra habitat than in boreal forest and ecotone habitat. Habitat use of wood frogs was strongly tied with available surface moisture and decreased water loss rates that were observed with plaster models. Environmental conditions, such as wind speed and ground temperature, explained 58% and 91% of the variation in water balance and temperature of plaster models. Maintaining physiological conditions may be challenging for semi‐aquatic ectotherms in environments vulnerable to future climate change. The ability to predict physiological conditions based on environmental conditions, as demonstrated in our study, can help understand how wildlife will respond to climatic changes.
Intratumoral genetic and immune microenvironmental heterogeneity in T4N0M0 (diameter ≥ 7 cm) non‐small cell lung cancers
Authors: Zhang Jia−Tao , Dong Song , Ji Li−Yan , Zhou Jia−Ying , Chen Zhi− Hong , Su Jian , Zhu Qing−Ge , Wang Meng−Min , Ke E−E. , Sun Hao , Li Xue−Tao , Yang Jin−Ji , Zhou Qing , Zhang Xu− Chao , Gao Xuan , Yang Xue−Ning , Xia Xuefeng , Yi Xin , Zhong Wen−Zhao , Wu Yi−Long 
Published: April 2022

AbstractBackgroundStarting with low metastatic capability, T4N0M0 (diameter ≥ 7 cm) non‐small cell lung cancers (NSCLCs) constitute a unique tumor subset, as with a large tumor size but no regional or distant metastases. We systematically investigated intratumoral heterogeneity, clonal structure, chromosomal instability (CIN), and immune microenvironment in T4N0M0 (≥7 cm) NSCLCs.MethodsWhole‐exome sequencing, RNA sequencing, and multiplex immunohistochemistry (mIHC) staining were conducted to analyze 24 spatially segregated tumor samples from eight patients who were pathologically diagnosed with T4N0M0 (diameter ≥ 7 cm) NSCLCs. The adjacent normal tissues and peripheral blood served as controls.ResultsIn total, 35.2% of mutations and 91.1% of somatic copy number alterations were classified as subclonal events, which exhibited widespread genetic intratumoral heterogeneity. In contrast, a low degree of CIN was observed. None of the patients had genome doubling. The burden of loss of heterozygosity, aneuploidy, and the genome instability index of these tumors were significantly lower than those in the TRACERx cohort. Expression profiles revealed significantly upregulated expression of cell division‐related signals and the G2/M checkpoint pathway. In addition, a similar expression pattern of the immune microenvironment was observed in different regions of the tumor, which was confirmed by mIHC profiles.ConclusionsOur study indicates the presence of intratumoral genetic heterogeneity and immune microenvironmental heterogeneity features in T4N0M0 NSCLCs, and the low degree of CIN may be related to the low metastatic capability.
The optimal therapy strategy for epidermal growth factor receptor‐mutated non‐small cell lung cancer patients with brain metastasis: A real‐world study from Taiwan
Authors: Cheng Wen‐Chien , Shen Yi‐Cheng , Chien Chun‐Ru , Liao Wei‐Chih , Chen Chia‐Hung , Hsia Te‐Chun , Tu Chih‐Yeh , Chen Hung‐Jen 
Published: April 2022

AbstractBackgroundThe treatment options for epidermal growth factor receptor (EGFR)‐mutated non‐small cell lung cancer (NSCLC) with brain metastases (BMs) include EGFR‐tyrosine kinase inhibitors (TKIs), stereotactic radiosurgery (SRS), whole‐brain radiotherapy, brain surgery, and antiangiogenesis therapy. As treatment options evolve, redefining optimal treatment strategies to improve survival are crucial.MethodsA total of 150 EGFR‐mutant NSCLC patients with BMs who received first‐ or second‐generation EGFR‐TKIs as first‐line treatment between January 2012 and October 2019 were included in this analysis.ResultsAfter multivariate analysis, patients with the graded prognostic assessment for lung cancer using molecular markers (Lung‐mol GPA) ≥3 (hazard ratio [HR]: 0.538, 95% confidence interval [CI]: 0.35–0.83), who received afatinib or erlotinib as first‐line treatment (HR: 0.521, 95% CI: 0.33–0.82), underwent SRS therapy (HR: 0.531, 95% CI: 0.32–0.87), or were sequentially treated with osimertinib (HR: 0.400, 95% CI: 0.23–0.71) were associated with improved overall survival (OS). Furthermore, SRS plus EGFR‐TKI provided more OS benefits in patients with Lung‐mol GPA ≥3 compared with EGFR‐TKI alone in our patient cohort (44.9 vs. 26.7 months, p = 0.005). The OS in patients who received sequential osimertinib therapy was significantly longer than those without osimertinib treatment (43.5 vs. 24.3 months, p < 0.001), regardless of T790 mutation status (positive vs. negative vs. unknown: 40.4 vs. 54.6 vs.43.4 months, p = 0.227).ConclusionsThe study demonstrated that EGFR‐mutant NSCLC patients with BMs could be precisely treated with SRS according to Lung‐mol GPA ≥3. Sequential osimertinib was associated with prolonged survival, regardless of T790M status.
A metatranscriptomic approach to explore longitudinal tissue specimens from non‐healing diabetes related foot ulcers
Authors: Radzieta Michael , Peters Timothy J. , Dickson Hugh G. , Cowin Allison J. , Lavery Lawrence A. , Schwarzer Saskia , Roberts Tara , Jensen Slade O. , Malone Matthew 
Published: April 2022

Cellular mechanisms and/or microbiological interactions which contribute to chronic diabetes related foot ulcers (DRFUs) were explored using serially collected tissue specimens from chronic DRFUs and control healthy foot skin. Total RNA was isolated for next‐generation sequencing. We found differentially expressed genes (DEGs) and enriched hallmark gene ontology biological processes upregulated in chronic DRFUs which primarily functioned in the host immune response including: (i) Inflammatory response; (ii) TNF signalling via NFKB; (iii) IL6 JAK‐STAT3 signalling; (iv) IL2 STAT5 signalling and (v) Reactive oxygen species. A temporal analysis identified RN7SL1 signal recognition protein and IGHG4 immunoglobulin protein coding genes as being the most upregulated genes after the onset of treatment. Testing relative temporal changes between healing and non‐healing DRFUs identified progressive upregulation in healed wounds of CXCR5 and MS4A1 (CD20), both canonical markers of lymphocytes (follicular B cells/follicular T helper cells and B cells, respectively). Collectively, our RNA‐seq data provides insights into chronic DRFU pathogenesis.
Gender typicality and sexual minority labour market differentials
Authors: Burn Ian , Martell Michael E. 
Published: April 2022

AbstractSexual minorities experience significant differences in labour market outcomes relative to comparable heterosexuals, with larger differences in earnings than in labour supply. A common explanation of these differences is that they may reflect unobserved differences in masculinity and femininity in the sexual minority population. We leverage data on personality and behaviours in the National Study of Adolescent to Adult Health (Add Health) to test whether controlling for differences in masculinity and femininity through quantitative measures of gender typicality eliminates labour market differentials. While we find evidence that gender typicality does affect labour market outcomes of men and women on average, we find no evidence of a differential effect for gays and lesbians. Controlling for gender typicality does not affect the sexual orientation labour market differentials. The evidence suggests that existing estimates of earnings differentials are not affected by omitted variable bias due to not controlling for gender typicality.
Endogenous fluctuations and international business cycles
Authors: McKnight Stephen , Povoledo Laura 
Published: April 2022

AbstractWe introduce equilibrium indeterminacy into a two‐country incomplete asset model with imperfect competition to analyze the role of self‐fulfilling expectations or beliefs in explaining international business cycles. We find that, when self‐fulfilling beliefs are correlated with technology shocks, the model can account for the countercyclical behaviour observed for the terms of trade and real net exports while simultaneously generating higher volatilities relative to output, as in the data. The choice of the labour‐supply elasticity is shown to be critical for generating a negative correlation between the real exchange rate and relative consumption, thereby resolving the Backus–Smith puzzle.
Analysis of implant loss risk factors after simultaneous guided bone regeneration: A retrospective study of 5404 dental implants
Authors: Shen Xiaoting , Yang Sijia , Xu Yangbo , Xu Jiangang , Feng Yi , He Fuming 
Published: April 2022

AbstractPurposeThe purpose was to analyze the risk factors for implant loss after simultaneous guided bone regeneration (GBR).Materials and MethodsPatients who underwent implant placement with simultaneous GBR between January 2011 and December 2018 were screened for this study. The cumulative survival rate (CSR) was calculated using the life table method. Log‐rank test and Kaplan–Meier survival estimates were used to identify potential risk factors for implant loss. The association between the investigated variables and implant loss was determined using hazard ratios (HRs) obtained from a multivariate Cox regression analysis.ResultsA total of 3973 patients with 5404 implants were included in this study. The CSRs of the implants at 1, 5, and 10 years were 99.6%, 98.9%, and 98.7%, respectively. Male patient (HR = 2.94, 95% CI: 1.41–6.14), periodontitis (HR = 4.26, 95% CI: 2.05–9.86), tissue‐level implants (HR = 3.02, 95% CI: 1.30–6.98), narrow implants (HR = 2.71, 95% CI: 1.12–6.57), and implant length ≤10 mm (HR = 2.91, 95% CI: 1.41–6.02) significantly increased the risk of implant loss (p < 0.05). The risk of implant loss was significantly higher in the maxillary posterior region (HR = 2.26, 95% CI: 1.04–4.90) than in the maxillary anterior region (p < 0.05). Compared to Straumann, Nobel (HR = 4.07, 95% CI: 1.75–9.44) and other implant systems (HR = 14.23, 95% CI: 4.32–46.85) showed a significantly higher risk of implant loss (p < 0.05).ConclusionMale patient, periodontitis, maxillary posterior region, Nobel implant system, other implant systems, tissue‐level implants, narrow implants, and implant length ≤10 mm were considered risk factors for implant loss after simultaneous GBR.
Sex‐dependent impact of microbiota status on cerebral μ‐opioid receptor density in fischer rats
Authors: Effah Felix , de Gusmão Taveiros Silva Nívea Karla , Vijayanathan Katie , Camarini Rosana , Joly Fatima , Taiwo Benjamin , Rabot Sylvie , Champeil‐Potokar Gaëlle , Bombail Vincent , Bailey Alexis 
Published: April 2022

Abstractμ‐opioid receptors (MOPr) play a critical role in social play, reward and pain, in a sex‐ and age‐dependent manner. There is evidence to suggest that sex and age differences in brain MOPr density may be responsible for this variability; however, little is known about the factors driving these differences in cerebral MOPr density. Emerging evidence highlights gut microbiota's critical influence and its bidirectional interaction with the brain on neurodevelopment. Therefore, we aimed to determine the impact of gut microbiota on MOPr density in male and female brains at different developmental stages. Quantitative [3H]DAMGO autoradiographic binding was carried out in the forebrain of male and female conventional (CON) and germ‐free (GF) rats at postnatal days (PND) 8, 22 and 116–150. Significant ‘microbiota status X sex’, ‘age X brain region’ interactions and microbiota status‐ and age‐dependent effects on MOPr binding were uncovered. Microbiota status influenced MOPr levels in males but not females, with higher MOPr levels observed in GF versus CON rats overall regions and age groups. In contrast, no overall sex differences were observed in GF or CON rats. Interestingly, within‐age planned comparison analysis conducted in frontal cortical and brain regions associated with reward revealed that this microbiota effect was restricted only to PND22 rats. Thus, this pilot study uncovers the critical sex‐dependent role of gut microbiota in regulating cerebral MOPr density, which is restricted to the sensitive developmental period of weaning. This may have implications in understanding the importance of microbiota during early development on opioid signalling and associated behaviours.
Ambient air pollution and epileptic seizures: A panel study in Australia
Authors: Chen Zhuying , Yu Wenhua , Xu Rongbin , Karoly Philippa J. , Maturana Matias I. , Payne Daniel E. , Li Lyra , Nurse Ewan S. , Freestone Dean R. , Li Shanshan , Burkitt Anthony N. , Cook Mark J. , Guo Yuming , Grayden David B. 
Published: April 2022

AbstractObjectiveEmerging evidence has shown that ambient air pollution affects brain health, but little is known about its effect on epileptic seizures. This work aimed to assess the association between daily exposure to ambient air pollution and the risk of epileptic seizures.MethodsThis study used epileptic seizure data from two independent data sources (NeuroVista and Seer App seizure diary). In the NeuroVista data set, 3273 seizures were recorded using intracranial electroencephalography (iEEG) from 15 participants with refractory focal epilepsy in Australia in 2010–2012. In the seizure diary data set, 3419 self‐reported seizures were collected through a mobile application from 34 participants with epilepsy in Australia in 2018–2021. Daily average concentrations of carbon monoxide (CO), nitrogen dioxide (NO2), ozone (O3), particulate matter ≤10 μm in diameter (PM10), and sulfur dioxide (SO2) were retrieved from the Environment Protection Authority (EPA) based on participants’ postcodes. A patient‐time‐stratified case‐crossover design with the conditional Poisson regression model was used to determine the associations between air pollutants and epileptic seizures.ResultsA significant association between CO concentrations and epileptic seizure risks was observed, with an increased seizure risk of 4% (relative risk [RR]: 1.04, 95% confidence interval [CI]: 1.01–1.07) for an interquartile range (IQR) increase of CO concentrations (0.13 parts per million), whereas no significant associations were found for the other four air pollutants in the whole study population. Female participants had a significantly increased risk of seizures when exposed to elevated CO and NO2, with RRs of 1.05 (95% CI: 1.01–1.08) and 1.09 (95% CI: 1.01–1.16), respectively. In addition, a significant association was observed between CO and the risk of subclinical seizures (RR: 1.20, 95% CI: 1.12–1.28).SignificanceDaily exposure to elevated CO concentrations may be associated with an increased risk of epileptic seizures, especially for subclinical seizures.