bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health technology assessment criteria as drivers of coverage with managed entry agreements: a case study of cancer medicines in four countries
Authors: Efthymiadou Olina 
Published: October 2022

Abstract
Background
Managed entry agreements (MEAs) continue to emerge in health technology assessment (HTA)-based decision-making, to address evidentiary uncertainties arising therein. Evidence on the HTA criteria that influence MEAs' uptake remains scarce. This study explores the HTA criteria that determine (i) if an HTA funding decision will be listed with conditions (LWC) other than a MEA, or with a MEA as a condition (LWCMEA), and ii) the MEA type implemented (i.e., financial, outcomes based, or combination).

Methods
HTA reports of all oncology medicines approved since 2009 in Australia, England, Scotland, and Sweden were searched to capture the clinical/economic evidence uncertainties raised in the decision-making process, the Social Value Judgements (SVJs) considered therein and the final coverage decision. Binary and multinomial logit models captured the probability (odds ratio (OR)) of a coverage decision being LWCMEA vs. LWC, and of the MEA being financial, outcomes based, or combination, based on the HTA criteria studied.

Results
23 (12%) LWC and 163 (88%) LWCMEA decisions were identified; 136 (83.4%) comprised financial, 10 (6.2%) outcomes based and 17 (10.4%) combination MEAs. LWCMEA decisions were driven by economic model utilities' uncertainties (7.16 < OR < 26.7, p < .05), and the innovation (8.5 < OR < 11.7, p < .05) SVJ. Outcomes based contracts were influenced by clinical evidence (OR = 69.2, p < .05) and relevance to clinical practice (OR = 26.4, p < .05) uncertainties, and rarity (OR = 46.2, p < .05) and severity (OR = 23.3, p < .05) SVJs. Financial MEAs were influenced by innovation (8.9 < OR < 9.3, p < .05) and societal impact (OR = 17.7, p < .0001) SVJs.

Conclusions
This study provides an empirical framework on the HTA criteria that shape payers' preferences in funding with MEAs, when faced with uncertainty.
Designing a shared freight service intelligence platform for transport stakeholders using mobile telematics
Authors: Heinbach Christoph , Meier Pascal , Thomas Oliver 
Published: October 2022

AbstractInternet of Things (IoT) technology transforms freight transport operations by adopting novel data-driven services and enables information sharing among actors involved in global transport chains. Mobile telematics represents emerging IoT technologies for global forwarding increasingly applied to full loads conveyed by freight transport assets (FTAs) (e.g., ISO containers) facilitating intelligent services. In this light, telematics-enabled FTAs support freight transport operations utilized by individual stakeholders in three overarching service dimensions: transport management, fleet management, and risk management. This topic is, however, understudied by information systems (IS) research and service science. For this reason, we establish a design science research project, conceptualize a shared Freight Service Intelligence Platform (FSIP), and introduce freight service intelligence as an interdisciplinary research field. To this aim, we first review related literature, interview 14 transport stakeholders, and theorize six meta-requirements. Second, we propose five design principles that indicate how the meta-requirements may be associated. Third, we develop a web-based prototype application to instantiate the proposed design principles comprising performance analytics, anomaly detection, risk assessment including prediction, data exchange, communication, and IS integration. Subsequently, we evaluate the application with six transport stakeholders and logistics software vendors. Finally, we conclude with a discussion on the implications of an emerging topic addressed by this paper.
Environmental Personhood as a Tool to Protect Nature
Authors: Łaszewska-Hellriegel Martyna 
Published: October 2022

AbstractThe escalating global ecological degradation underlines the continued importance of the need of effective nature protection. In recent years a new concept– “environmental personhood” was developed. The article analyses the concept and asks the question if it can help with the efficiency of protecting the nature. It is the attempt to transfer the essence of human rights to animals and ecosystem, so they will no longer be right’-less. This concept has some of its beginning in the idea of “common heritage of mankind”, which means that some places belong to the whole of humanity and that the resources of these places should be available to all. This article outlines the roots, the development and traces current trends in the legal personification of non-human persons. It asks legal-theoretical questions about the limits and possibilities of opening up the concept of legal personhood for non-human legal persons in order to protect the nature and discusses the possibility of creating new institutions that could protect it. The article also shows the importance of creating a new society sensitive to nature’s needs.
PET-Recycling — mit Enzymen gegen die Plastikkrise
Authors: Sonnendecker Christian 
Published: October 2022

AbstractMass production of inert plastics based on mineral-oil has become a problem to our environment due to the lack of sustainable recycling options. PET however consists of hydrolysable ester bonds, which enables several strategies. One aspiring technology is based on the enzymatic hydrolysis of PET. The basic building blocks of the polymer can be recovered to close the recycling loop for PET.
Bioreaktoren für vaskularisiertes Knochen-Tissue-Engineering
Authors: Böker Kai O. , Siegk Samuel , Pardo Luis A. , Bravo Miguel , Hahne Janne , Lehmann Wolfgang , Schilling Arndt F. 
Published: October 2022

AbstractTissue engineering (TE) has the potential to revolutionize human healthcare through creation of artificial tissue for medical applications. The vascular supply plays an important role in this process. To realize such vascularized tissues in the future, we developed a vascularized bioreactor system. The goal in the near future is to standardize the systems to enable to mimic existing in vivo systems. The long-term goal is the production of vascularized bone tissue for treatment of large bone defects in injured patients.
Raman-Spektroskopie in der Infektionsforschung
Authors: Cialla-May Dana , Rösch Petra , Popp Jürgen 
Published: October 2022

AbstractRaman spectroscopy allows to analyze bacteria and other microorganisms label and destruction free. With different Raman techniques either colonies on agar plates or small structures like single bacterial cells can be analyzed allowing for their identification as well as enabling 2D and 3D information of intracellular bacteria or biofilms. Using surface enhanced Raman spectroscopy (SERS) allows detecting and identifying viruses as well as antibiotics relevant in the treatment of infections.
Correlates of Physical Activity in 0- to 5-year-olds: A Systematic Umbrella Review and Consultation of International Researchers
Authors: Arts Jelle , Drotos Elizabeth , Singh Amika S. , Chinapaw Mai J. M. , Altenburg Teatske M. , Gubbels Jessica S. 
Published: October 2022

Abstract
Background
Many children aged 0–5 years do not meet the WHO physical activity guidelines. To develop effective, evidence-based interventions, it is necessary to understand which factors are associated with physical activity in early childhood.

Objective
To summarize the current evidence on correlates of physical activity in 0- to 5-year-old children.

Methods
First, a systematic umbrella review was conducted following PRISMA guidelines. PubMed, Embase, PsycINFO, and SPORTDiscus were searched up to May 2020 for systematic reviews examining the association between potential correlates and quantitatively measured physical activity in children aged 0–5.9 years. Included reviews were assessed on methodological quality, and results were categorized according to the socio-ecological model. Second, 31 international researchers of physical activity in young children participated in an expert panel to reflect on the outcomes of the umbrella review and propose directions for future research.

Results
Twenty-one reviews were included that examined a total of 98 potential correlates. When synthesizing all reviews, 23 correlates were found with consistent evidence for an association with a physical activity outcome. For most other potential correlates there was inconsistent evidence across reviews for associations with physical activity in young children. Although there was little overlap between the correlates identified in the umbrella review and determinants suggested by the expert panel, both confirmed the importance of socio-cultural, policy, and physical environmental factors in general.

Conclusion
Multiple correlates of young children's physical activity were identified. However, various methodological challenges (e.g., measurement instruments) and the large heterogeneity (e.g., study samples, correlates, and outcome measures) hindered formulating definitive conclusions. Moreover, none of the reviews reported on the interrelatedness between correlates, which would align with more holistic understandings of behavior. Our findings indicate the urgent need for establishing a common ground in definitions, assessment methods, and analytical methods to further the field of physical activity research in this tremendously important age group.

Prospero Registration Number
CRD42020184159.
Comparison of Intravenous Paracetamol, Dexketoprofen Trometamol, or Topical Lidocaine Use for Pain Relief in Scorpion Stings: A Placebo-Controlled, Randomized Study
Authors: Turgut Kasım , Yavuz Erdal , Gülaçtı Umut , Aydın İrfan , Sönmez Cihat , Aktaş Nurettin , Arslan Ebru 
Published: October 2022

Introduction After a scorpion sting, patients commonly present to hospitals with pain. Our study sought to compare the analgesic efficacy of IV paracetamol, IV dexketoprofen trometamol, topical lidocaine, and placebo in patients reporting pain after presenting with a history of scorpion sting. Methods This double-blind, randomized, placebo-controlled study was conducted in the emergency department of a tertiary hospital. Adult patients who presented with the complaint of pain after a scorpion sting and did not have systemic findings were randomly assigned to 1 of the following 4 groups: IV paracetamol, IV dexketoprofen trometamol, topical lidocaine, and placebo. The visual analog scale scores were measured at the time of presentation to the emergency department and at 30 and 60 min to determine the pain intensity. Results The study included 106 patients, of whom 30 were in the paracetamol group, 26 in the dexketoprofen trometamol group, 25 in the topical lidocaine group, and 25 in the placebo group. We did not find a different analgesic effect among the groups in the first 30 min ( P=0.185). IV paracetamol, dexketoprofen trometamol, and topical lidocaine did not show different analgesic effects in the first 60 min ( P>0.05). IV paracetamol and dexketoprofen trometamol were found to provide a more effective analgesia than the placebo at 60 min ( P<0.05). The analgesic effects of topical lidocaine and placebo did not differ ( P=0.330). Conclusions IV paracetamol and IV dexketoprofen trometamol provided analgesia in the first 60 min, similar to topical lidocaine but superior to placebo.
Reviving botany in the curriculum: the botanical journey of two Western Australian early childhood teachers
Authors: Beasley Kimberley , Hesterman Sandra , Lee-Hammond Libby 
Published: October 2022

AbstractEnvironmental education across the early years has become increasingly important in Australia since the implementation of the Early Years Learning Framework and the Australian Curriculum. These documents promote a connection to nature for young children as well as environmental responsibility. In Western Australia, large areas of natural environments are bush spaces, accessible by young children, families and schools. There is no existing research investigating early childhood teacher’s knowledge of plants in these bush spaces and the utilisation of these spaces in teaching botany as part of their teaching practice. The discussion in this article examines part of a larger year-long multi-site case study of the changes in the botanical understanding of two early childhood teachers of children aged 5–8 years, in Western Australian schools both before and after the Mosaic Approach, botanical practices and Indigenous knowledges were incorporated into their teaching practice. This article focuses on the changes of botanical literacies of the early childhood teachers specifically. The findings suggest that using inquiry-based and place-based methods and including First Nations Peoples’ perspectives about plants whilst teaching in the bush can significantly increase the plant knowledge and understanding of teachers, as well their own scientific and botanical literacies.
Radar attenuation demonstrates advective cooling in the Siple Coast ice streams
Authors: Hills Benjamin H. , Christianson Knut , Jacobel Robert W. , Conway Howard , Pettersson Rickard 
Published: October 2022

AbstractIce streams are warmed by shear strain, both vertical shear near the bed and lateral shear at the margins. Warm ice deforms more easily, establishing a positive feedback loop in an ice stream where fast flow leads to warm ice and then to even faster flow. Here, we use radar attenuation measurements to show that the Siple Coast ice streams are colder than previously thought, which we hypothesize is due to along-flow advection of cold ice from upstream. We interpret the attenuation results within the context of previous ice-temperature measurements from nearby sites where hot-water boreholes were drilled. These in-situ temperatures are notably colder than model predictions, both in the ice streams and in an ice-stream shear margin. We then model ice temperature using a 1.5-dimensional numerical model which includes a parameterization for along-flow advection. Compared to analytical solutions, we find depth-averaged temperatures that are colder by 0.7°C in the Bindschadler Ice Stream, 2.7°C in the Kamb Ice Stream and 6.2–8.2°C in the Dragon Shear Margin of Whillans Ice Stream, closer to the borehole measurements at all locations. Modelled cooling corresponds to shear-margin thermal strengthening by 3–3.5 times compared to the warm-ice case, which must be compensated by some other weakening mechanism such as material damage or ice-crystal fabric anisotropy.
The hidden power of implicit collective memory
Authors: Erll Astrid 
Published: October 2022

AbstractOver the past decades, the field of memory studies has produced a wealth of research on explicit (conscious, commemorative, official) collective memory. But beyond this realm of the visible, there is a largely hidden world of ‘implicit collective memory’. Elements of this invisible world include narrative schemata, stereotypes, patterns of framing, or world models, which are usually not explicitly known or addressed, but get passed on from generation to generation – in order to shape perception and action in new situations. Implicit collective memory is pervasive and powerful. But it is difficult to trace. It is therefore time to join forces for its systematic study: Drawing on approaches from psychology, sociology, communication studies, anthropology, media culture studies, literary studies, and mnemohistory, this article proposes some building blocks for a future transdisciplinary field of research on implicit collective memory.
Digital African Literatures and the Coloniality of Data
Authors: Yékú James 
Published: October 2022

AbstractDigital iterations of African literary texts present scholarly opportunities to interrogate how literature produced and circulated on digital media becomes entangled with the capitalist politics of datafication. In the data paradigm described in the article, literary representations are subject to the workings of neoliberal capital and the constraints of algorithmic systems. Through a postcolonial approach that puts the digital humanities in conversation with African literary studies, the article transcends how digital technologies have evidently changed African literature and tackles thecostsof digital literary cultures and networks from Africa. I examine data relations through an African literary culture, which, in the current moment, indisputably exhibits the attainment of new and complex elements including the integration of digital affordances in the production and critical reception of texts. How African literary expressions in a digital age circulate in market-driven digital platforms like Facebook and YouTube makes the subjects of data capitalism or the coloniality of data as important for African literature as the expanded literary networks enabled by the digital.
Equation balance in time series analysis: lessons learned and lessons needed
Authors: Pickup Mark 
Published: October 2022

AbstractThe papers in this symposium use Monte Carlo simulations to demonstrate the consequences of estimating time series models with variables that are of different orders of integration. In this summary, I do the following: very briefly outline what we learn from the papers; identify an apparent contradiction that might increase, rather than decrease, confusion around the concept of a balanced time series model; suggest a resolution; and identify a few areas of research that could further increase our understanding of how variables with different dynamics might be combined. In doing these things, I suggest there is still a lack of clarity around how a research practitioner demonstrates balance, and demonstrates what Pickup and Kellstedt (2021) call I(0) balance.
A 20-year audit of the outcomes of stenting with the Montgomery Safe-T-Tube at a tertiary hospital in South Africa
Authors: Klopper G J , Adeniyi O V 
Published: October 2022

AbstractObjectiveThis study aimed to describe the epidemiology of laryngotracheal stenosis within a resource-constrained setting, whilst exploring the outcome correlates unique to Montgomery Safe-T-Tube stented laryngotracheoplasty.MethodsA retrospective cross-sectional study of patients who underwent Montgomery Safe-T-Tube stented laryngotracheoplasty between January 2000 and December 2019 was performed.ResultsAmongst 75 patients, most lesions were iatrogenic (78.7 per cent) and high-grade in severity (84 per cent). Following 101 laryngotracheoplasties, 57 patients (76 per cent) were successfully decannulated. Young age (84.6 per cent; p = 0.009), low-grade stenosis (100 per cent; p = 0.034) and airway-framework structural integrity (79.3 per cent; p = 0.004) were significant correlates of success. Restenosis (n = 43; 57.3 per cent), occurring at a median of 9.37 weeks following decannulation, was predominantly associated with antecedent dilatation (96.3 per cent; p < 0.001).ConclusionDemographic and clinical profiles play a pivotal role in the outcomes and complications of Montgomery Safe-T-Tube stented laryngotracheoplasty. The success rate validates the procedure within a resource-limited setting. There exist critical periods following both surgery and decannulation when the occurrence of adverse events is most likely.
Rewriting the hills: Youth sociality as a mode of navigating unemployment in a context of outmigration in North India
Authors: Deuchar Andrew 
Published: October 2022

AbstractThis article examines the ways in which educated yet unemployed young people attempt to configure ways of being productive in a small hill town in North India. Young people who do not migrate to large urban centres from this township are the subject of contradictory discourses: in some moments they are seen as an antidote to the ‘problem of migration’, but in other moments they are ridiculed for not making good use of their time. Both discourses suggest a present wherein young people are not productive. Drawing on ethnographic material gathered over a ten-month period, this article frames youth sociality as a mode registering a sense of productivity and navigating unemployment. I argue that while hanging out at a computer shop, young men were distancing themselves from notions of idling and creating masculine youth cultures in which they sought to situate themselves as productive young people. I make this argument by unpacking exchanges between these young men and by analysing the tangible ways they helped the shop function. I also draw debates about youth sociality into dialogue with theoretical insights from rural geography to illuminate how educated youth attempt to imbue rural and peri-urban space with new possibilities. I show how educated youth attempt to reanimate rural space and forge affirmative rural futures by emphasizing their connections with Indian modernity. Attending to the ways in which educated yet unemployed youth attempt to situate themselves within productive relations is set to become of increasing importance given the impacts of the COVID-19 pandemic.
Fiscal capacity in non-democratic states: the origins and expansion of the income tax
Authors: Andersson Per F. 
Published: October 2022

AbstractFiscal capacity is regularly linked to warfare and democratization. However, the majority of income taxes – a cornerstone of government finance – were introduced by non-democratic states in peacetime. This paper is concerned with how autocratic politics shape the adoption and expansion of income taxes. Political institutions help overcome a commitment problem related to investments in taxation. To avoid being deposed by his or her elite supporters, a ruler needs to guarantee that new taxes will not be used opportunistically (e.g. expropriating the elite). If the elite supporters can effectively monitor the government, any transgressions will be detected and punishable. Institutions such as legislatures solve this commitment problem when they allow oversight and monitoring over the executive branch. The empirical implications are straightforward: in places with strong institutional oversight, which allows the elite to monitor the executive, we should observe higher fiscal capacity. I find support for this by analyzing newly available historical datasets over tax revenues, tax introduction dates, and political institutions.
Higher Sensitivity of Northern Hemisphere Monsoon to Anthropogenic Aerosol Than Greenhouse Gases
Authors: Cao Jian , Wang Hao , Wang Bin , Zhao Haikun , Wang Chao , Zhu Xiaowei 
Published: October 2022

AbstractBecause increased greenhouse gas emissions considerably warm and moisten the Earth's atmosphere, one may expect an increase in monsoon precipitation during the historical period. However, we find the observed Northern Hemisphere land summer monsoon (NHLM) precipitation has significantly decreased since 1901. Simulations from Coupled Model Intercomparison Project Phase 6 (CMIP6) well reproduce global warming and the drying of NHLM since the industrial revolution when forced by observed external forcings. Result from single forcing experiment shows that the anthropogenic aerosol (AA) dominates the Northern Hemisphere (NH) monsoon precipitation drying, while the greenhouse gases (GHG) largely control surface warming. Thus, the NH monsoon precipitation responds to AA more sensitively than the GHG. The AA can more effectively modulate downward solar radiation reaching the surface, decreasing evaporation and weakening monsoon circulations by reducing the interhemispheric temperature difference and land‐ocean thermal contrast, albeit with the same efficiency of the thermodynamic effect in the two forcings. Our result indicates the future intensive reduction of aerosol emission may rapidly recover the NH monsoon precipitation.