bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness and safety of hypotensive therapy of primary glaucoma with a Russian generic fixed combination of dorzolamide and timolol
Authors: Petrov S. Yu. , Kalinina O. M. , Zhuravleva A. N. , Filippova O. M. , Yakubova L. V. , Vasilenkova L. V. , Kosakyan S. M. , Markelova O. I. 
Published: September 2022

Purpose: a comparative study of the efficacy and safety of the generic drug Dorzial Plus, an analogue of the original reference drug Cosopt®, in patients with primary open-angle glaucoma (POAG).Material and methods. The study involved 80 patients of both sexes aged 55–75 with newly diagnosed POAG of the initial and advanced stages with uncompensated intraocular pressure (IOP), of which 40 patients (study group) received Dorzial Plus and 40 patients (comparison group) received the reference drug (Cosopt®). Hypotensive efficacy of the drugs in both groups was assessed using a portable ophthalmic tonometer Icare PRO (Finland) by reducing IOP from the initial level after 1 week, 1 month and 3 months of treatment.Results. In both groups, the screening showed comparable average IOP values: 26.7 ± 3.2 mm Hg in the reference drug group and 27.4 ± 2.8 mm Hg in the Dorzial Plus group. After 1 week of therapy with Cosopt, IOP showed a significant decrease of 33% (reduction to 17.9 ± 3.2 mm Hg), while the group receiving Dorzial Plus demonstrated a 31% decrease (reduction to 18.9 ± 1.7 mm Hg). After 1 month of the instillation regimen, a slight increase in P0 (of about 3%) was recorded in both groups (increase to 18.7 ± 2.3 and 19.7 ± 2.0 mm Hg, respectively). By the end of the 3 months’ follow-up period, IOP decrease level with respect to the baseline remained practically the same, amounting to 30 and 29% (up to 18.6 ± 1.8 and 19.5 ± 2.3 mm Hg), respectively. The state of the ocular surface showed a slightly negative dynamics of tear film rupture time and OSDI index in the reference drug group, which could be observed throughout 3 months of therapy. In the study group, therapy with preservative-free drug containing a moisturizing agent (sodium hyaluronate) revealed a significantly changed OSDI index, manifesting itself in restructured severity of the evaluated features.Conclusion. Dorzial Plus reduces IOP in POAG patients by an average of 30% of the baseline, so that its hypotensive efficacy is comparable to the original fixed combination Cosopt. The tolerability analysis of the study drug demonstrates a significant positive dynamic of the state of the ocular surface as soon as 3 months after therapy start.
Optimization of Multiple Helical Fillets Surface to Suppress Rain-wind Vibration of Stay Cables: A Wind Tunnel Investigation
Authors: Nguyen Duy Thao , Vo Duy Hung , Hai Viet , Haque Md. Naimul 
Published: September 2022

Aims:
To develop a new cable surface for control rain wind induced cable vibration of stay cable.

Background:
Stay cables are light and vulnerable structures. Therefore, it can be easily excited by wind or rain wind interaction. Stay cables wrapped with a single helical fillet have been proposed so far. However, these countermeasures could prevent cable vibration well, especially in dry conditions.
Objective: Therefore, the objective of this research is to develop a new cable surface to control not only RWIV but also dry galloping of stay cable.

Methods:
A wind tunnel test will be used to investigate the RWIV characteristics and its new countermeasure.
Results: First, a rain wind-induced vibration of circular stay cable was reproduced in a wind tunnel environment. The effect of upper and lower water rivulets was examined to understand their role on RWIV better. A rainfall simulator was employed to generate artificial rainfall for two different wind tunnel experiments. Finally, to control the RWIV of stay cables, novel multiple helical surface fillets were used. The upper and lower rain rivulets can play a significant role in energizing the RWIV. It was also found that the multiple helical surface fillets can suppress the cable vibration well both in wet and dry conditions.

Conclusion:
Multiple helical fillets cable surface could successfully prevent both the RWIV and dry galloping. To fabricate helical fillet cable to control cable vibration, 04 to 12 fillets with sizes ranging from 3mmx7.5mm to 5mmx7.5mm and a pitch of 2.95D-4.78D (D: cable diameter) are the most influential parameters and suggested herewith for practical application.
The effect of teachers' perceptions of the TAM learning model seen on the student’s learning outcomes in high school
Authors: Nugraha Ugi , Ekawarna Ekawarna , Ali Muhammad , Adhanegara Try Arianto 
Published: September 2022

Technology is an important aspect in improving the process of student development This study attempts to examine how are the descriptive results of teacher perceptions and student learning outcomes and how are the perceptions of the application of the tam model applied to student learning outcomes. The sample of this research is as many as fifty teachers who teach subjects physical education with a working period of 1-8 years and 9-16 years. The method used in this research is a mixed method with quantitative data as primary data and qualitative data as reinforcing data. In the results obtained, it can be seen that there is an influence between teacher perceptions of the Technology Acceptance Model (TAM) learning model which measures the level of understanding of students in interactive multimedia learning media on student learning outcomes, and the results of teacher interviews that today's technology needs are very important to improve learning. Therefore, this test is very important because there are no researchers who have tested these variables and there is an influence from the variables being tested. Therefore, this study aims to examine the results of descriptive statistics on teacher perceptions seen from student learning outcomes, and measure the effectiveness of the perception of the application of the Tam model on student learning outcomes.
Development of physical fitness test for mild intellectual disabilities aged 13-15 years
Authors: Sumaryanti Sumaryanti , Nugroho Sigit , Visalim Aqim , Ndayisenga Japhet 
Published: September 2022

This study aims to compile a physical fitness test for mild intellectual disability, test the suitability of the test in terms of suitability, convenience, and safety. The developed tests consist of a bench up and down test, a lying down test, a sitting test and a body mass index test. The stages of development carried out include planning stage, preparation stage, trial, evaluation and revision, and final product. The experimental subjects in this study were children with mild intellectual disabilities aged 13-15 years, totaling 148 people who were divided into limited trial subjects, expanded trial subjects, and validity and reliability test subjects. Validity data analysis technique with two tests using the composite score method and using Doolittle analysis, and reliability data analysis using alpha coefficient analysis. Based on the results of the study, a set of tests was obtained to measure the physical fitness of persons with mild intellectual disabilities with very high validity and reliability tests, where the validity of the test for boys is 0.968 and for girls is 0.914. While the test reliability value for men is 0.896 and for women is 0.883. The physical fitness test was developed according to the characteristics of mild mental retardation which included components on cardiovascular endurance, muscle strength and endurance, flexibility, and body composition.
The Potential Role of an Adjunctive Real-Time Locating System in Preventing Secondary Transmission of SARS-CoV-2 in a Hospital Environment: Retrospective Case-Control Study
Authors: Kim Min Hyung , Ryu Un Hyoung , Heo Seok-Jae , Kim Yong Chan , Park Yoon Soo 
Published: September 2022

Background
There has been an increasing demand for new technologies regarding infection control in hospital settings to reduce the burden of contact tracing.

Objective
This study aimed to compare the validity of a real-time locating system (RTLS) with that of the conventional contact tracing method for identifying high-risk contact cases associated with the secondary transmission of SARS-CoV-2.

Methods
A retrospective case-control study involving in-hospital contact cases of confirmed COVID-19 patients, who were diagnosed from January 23 to March 25, 2022, was conducted at a university hospital in South Korea. Contact cases were identified using either the conventional method or the RTLS. The primary endpoint of this study was secondary transmission of SARS-CoV-2 among contact cases. Univariate and multivariable logistic regression analysis comparing test positive and versus negative contact cases were performed.

Results
Overall, 509 and 653 cases were confirmed by the conventional method and the RTLS, respectively. Only 74 contact cases were identified by both methods, which could be attributed to the limitations of each method. Sensitivity was higher for the RTLS tracing method (653/1088, 60.0%) than the conventional tracing method (509/1088, 46.8%) considering all contact cases identified by both methods. The secondary transmission rate in the RTLS model was 8.1%, while that in the conventional model was 5.3%. The multivariable logistic regression model revealed that the RTLS was more capable of detecting secondary transmission than the conventional method (adjusted odds ratio 6.15, 95% CI 1.92-28.69; P=.007).

Conclusions
This study showed that the RTLS is beneficial when used as an adjunctive approach to the conventional method for contact tracing associated with secondary transmission. However, the RTLS cannot completely replace traditional contact tracing.
Employment Status and Work Functioning among Kidney Transplant Recipients
Authors: Knobbe Tim J. , Kremer Daan , Abma Femke I. , Annema Coby , Berger Stefan P. , Navis Gerjan J. , van der Mei Sijrike F. , Bültmann Ute , Visser Annemieke , Bakker Stephan J.L. 
Published: September 2022

Background and objectives
To date, employment figures of kidney transplant recipients in Europe are inconsistent. Additionally, little is known about work functioning of employed kidney transplant recipients and work functioning trajectories before and after transplantation.

Design, setting, participants, & measurements
Data from the ongoing TransplantLines Biobank and Cohort study and from community-dwelling employed adults were used. Health-related work functioning of kidney transplant recipients was assessed with the Work Role Functioning Questionnaire 2.0 and compared with potential kidney donors and community-dwelling employed adults.

Results
We included 668 kidney transplant recipients of working age (59% men, age 51±11 years) at median 3 (interquartile range, 2–10) years after transplantation, 246 potential kidney donors of working age (43% men, age 53±9 years), and 553 community-dwelling employed adults (70% men, age 45±11 years). The proportion of employed kidney transplant recipients was lower compared with potential kidney donors (56% versus 79%). If employed, the work functioning score of kidney transplant recipients was slightly lower compared with employed potential kidney donors yet higher compared with community-dwelling employed adults (medians 91 [interquartile range, 76–98], 94 [interquartile range, 85–99], and 88 [interquartile range, 79–95], respectively). Backward linear regression analyses revealed that lower educational level, having a kidney from a deceased donor, presence of tingling or numbness of hands or feet, presence of concentration/memory problems, presence of anxiety, and presence of severe fatigue were independently associated with lower work functioning among kidney transplant recipients. Additional subgroup analyses showed that work functioning scores were lower before transplantation than at 12 months after transplantation (83 [interquartile range, 66–93] versus 92 [interquartile range, 88–98], respectively; P=0.002).

Conclusions
Stable employed kidney transplant recipients report to function well at work. In addition, this study shows that self-reported work functioning is higher after successful kidney transplantation compared with before transplantation.

Clinical Trial registry name and registration number:
TransplantLines Biobank and Cohort study, NCT03272841

Podcast
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2022_09_26_CJN05560522.mp3.
Studying the Mechanical Properties of Denture Base Materials Fabricated from Polymer Composite Materials
Authors: Oleiwi Jawad Kadhim , Hamad Qahtan Adnan 
Published: September 2022

In this research, the effect of adding two different types of reinforcing particles was investigated, which included: nano-zirconia (nano-ZrO2) particles and micro-lignin particles that were added with different volume fractions of 0.5%, 1%, 1.5% and 2% on the mechanical properties of polymer composite materials. They were prepared in this research, as a complete prosthesis and partial denture base materials was prepared, by using cold cure poly methyl methacrylate (PMMA) resin matrix. The composite specimens in this research consist of two groups according to the types of reinforced particles, were prepared by using casting methods, type (Hand Lay-Up) method. The first group consists of PMMA resin reinforced by (nano-ZrO2) particles, while the second group consists of PMMA resin reinforced by (micro-lignin) particles.
The mechanical tests performed in this research includedtensile test, compression test, impact test and hardness test. The results of this study showed that the values of tensile modulus of elasticity, compressive strength and hardness properties increased with increasing the volume fraction of these particles in PMMA composite materials. While, the values of tensile strength, elongation and impact strength properties decreased. Also, the addition of (nano-ZrO2) particles showed greater effect than that of (micro-lignin) particles in some properties of PMMA composite materials for prosthesis denture base materials specimens, while they have lower effect for the other properties.
EXPLORING THE COMMUNICATIVE-NESS OF INDONESIAN ENGLISH COURSEBOOK: A CONTENT ANALYSIS
Authors: Sibakhul Milad Malik Hidayatulloh  , Riffat Haqhani Zulkifli  
Published: September 2022

One thing cannot be denied from teaching and learning process is teaching material and methodology. They are often used interchangeably. Therefore, the creation of the teaching materials is underpinned based on the methodology that has been widely used and existed. Communicative Language Teaching (CLT) as the methodology has been widely implemented in the classroom and materials in teaching and learning language. However, the CLT principles in the textbook are not much evaluated. Therefore, this research aims to evaluate the CLT principles in the English textbook in Indonesia, to be exact Bahasa Inggris SMA Kelas 11 Semester 2 Textbook for Secondary Students in Indonesia. In evaluation process, the researchers used an adopted textbookâ€™s evaluation checklist from Grantâ€™s and Cunningsworthâ€™s evaluation tools. Furthermore, there are five aspects to be focused which are the material, CLT claims, activities, provided skills, and tasks in the textbook. The findings showed that the textbook is not really implementing the principles of CLT. Moreover, it can be recognized from its activity and skills. Therefore, several aspects such as task, activity, and skills are needed to be improved. At the end of the chapter, suggestion for improving is also attached to improve the coursebook.
Embolización transcatéter del injerto renal en pacientes con síndrome de intolerancia: reporte de tres casos en un grupo de trasplantes
Authors: Anaya Taboada Marco , Cabellero-Tovar Dayana , Patiño Jaramillo Nasly , Garcia Lopez Andrea , Girón Luque Fernando 
Published: September 2022

Introducción: el síndrome de intolerancia es un proceso inflamatorio que ocurre hasta en un tercio de los pacientes con pérdida del injerto. Cuando no se obtiene una mejoría de los síntomas con el manejo médico, se indica la realización de nefrectomía del riñón trasplantado, sin embargo, este es un procedimiento invasivo que puede estar asociado a mayor morbilidad y mortalidad. Dada la fragilidad de estos pacientes, se plantea la embolización transcatéter del injerto como una alternativa válida y menos invasiva para el tratamiento de este síndrome.
Objetivo: describir el uso de la embolización transcatéter como tratamiento al síndrome de intolerancia del injerto.
Presentación del caso: se reportan tres casos clínicos de pacientes con sintomatología de entre 15 y 20 días de evolución, consistentes en dolor y tumefacción sobre riñón trasplantado y otros signos y síntomas reportados fueron fiebre, hiporexia, pérdida de peso y hematuria macroscópica. Se describe la evolución de los síntomas que en ninguno de los casos expuestos tuvieron mejoría con el ajuste inmunosupresor, descartando en todos los casos etiología infecciosa y estableciéndose así la sospecha síndrome de intolerancia del injerto. Los pacientes fueron manejados con embolización transcatéter de la arteria del riñón trasplantado y el éxito del tratamiento se definió por la resolución de los síntomas.
Discusión y conclusión: entre las primeras 24-48 horas posprocedimiento, los pacientes presentaron una evolución satisfactoria y, finalmente, egreso. La embolización transcatéter del injerto es una alternativa segura a la nefrectomía del trasplante y que es menos invasiva para el tratamiento del síndrome de intolerancia del injerto.
The Portfolio Diet and Incident Type 2 Diabetes: Findings From the Women’s Health Initiative Prospective Cohort Study
Authors: Glenn Andrea J. , Li Jie , Lo Kenneth , Jenkins David J.A. , Boucher Beatrice A. , Hanley Anthony J. , Kendall Cyril W.C. , Shadyab Aladdin H. , Tinker Lesley F. , Chessler Steven D. , Howard Barbara V. , Liu Simin , Sievenpiper John L. 
Published: September 2022

OBJECTIVE
A plant-based dietary pattern, the Portfolio Diet, has been shown to lower LDL cholesterol and other cardiovascular disease risk factors. However, no study has evaluated the association of this diet with incident type 2 diabetes.

RESEARCH DESIGN AND METHODS
This analysis included 145,299 postmenopausal women free of diabetes at baseline in the Women’s Health Initiative (WHI) Clinical Trials and Observational Study from 1993 to 2021. Adherence to the diet was assessed with a score based on six components (high in plant protein [soy and pulses], nuts, viscous fiber, plant sterols, and monounsaturated fat and low in saturated fat and cholesterol) determined from a validated food-frequency questionnaire. We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% CIs of the association of the Portfolio Diet, alongside the Dietary Approaches to Stop Hypertension (DASH) and Mediterranean diets, with incident type 2 diabetes, with adjustment for potential confounders.

RESULTS
Over a mean follow-up of 16.0 years, 13,943 cases of incident type 2 diabetes were identified. In comparisons of the highest with the lowest quintiles of adherence, the HRs for risk of incident type 2 diabetes were 0.77 (95% CI 0.72, 0.82) for the Portfolio Diet, 0.69 (0.64, 0.73) for the DASH diet, and 0.78 (0.74, 0.83) for the Mediterranean diet. These findings were attenuated by 10% after additional adjustment for BMI.

CONCLUSIONS
Greater adherence to the plant-predominant Portfolio, DASH, and Mediterranean diets was prospectively associated with lower risk of type 2 diabetes in postmenopausal women.
Prescription Patterns of Cardiovascular and Kidney Protective Therapies Among Patients with Type 2 Diabetes and Chronic Kidney Disease
Authors: Lamprea-Montealegre Julio A. , Madden Erin , Tummalapalli Sri Lekha , Chu Chi D. , Peralta Carmen A. , Du Yuxian , Singh Rakesh , Kong Sheldon X. , Tuot Delphine S. , Shlipak Michael G , M. Estrella Michelle 
Published: September 2022

<p> </p>
<p><strong>Objective</strong></p>
<p>To assess the prevalence and correlates of prescription of sodium-glucose co-transporter-2-inhibitors (SGLT2i) and/or glucagon-like peptide-1-receptor agonists (GLP1-RA) in persons with type 2 diabetes mellitus (T2DM) with and without chronic kidney disease (CKD). </p>
<p><strong>Methods</strong></p>
<p>Cross-sectional analyses of SGLT2i and GLP1-RA prescriptions from January 1st, 2019, to December 31st, 2020, in the Veterans Health Administration System. The likelihood of prescriptions was examined by presence or absence of CKD and by predicted risks of atherosclerotic cardiovascular disease (ASCVD) and end-stage kidney disease (ESKD). </p>
<p><strong>Results</strong></p>
<p>Of 1,197,880 adults with T2DM, SGLT2is and GLP1-RAs were prescribed to 11% and 8% of patients overall, and to 12% and 10% of those with concomitant CKD, respectively. In adjusted models, patients with severe albuminuria were less likely to be prescribed SGLT2i or GLP1-RA versus non-albuminuric patients with CKD: OR (95% CI) = 0.91 (0.89, 0.93) and 0.97 (0.94, 1.00), respectively. Patients with 10-year ASCVD risk >20% (versus <5%), had lower odds of SGLT2i use (OR=0.55 (0.52, 0.59)) and GLP1-RA prescription (OR=0.54 (0.50, 0.59)). A 5-year ESKD risk >5%, compared with <1%, were associated with lower likelihood of SGLT2i prescription (OR=0.63 (0.59, 0.67)) but higher likelihood of GLP1-RA prescription (OR=1.53 (1.46, 1.61)).</p>
<p><strong>Conclusions</strong></p>
<p>Among a large cohort of patients with T2DM, prescription of SGLT2i and GLP1-RA was low in those with CKD. We observed a “risk-treatment paradox”, whereby patients with higher risk of adverse outcomes were less likely to receive these therapies. </p>
Palaeomagnetic suitability of a new section with a potential lower boundary for the Quaternary on the left bank of the lower River Danube
Authors: Hlavatskyi D.V. , Veklych Y.M. , Bakhmutov V.G. , Shpyra V.V. , Skarboviychuk T.V. , Yakukhno V.I. , Poliachenko I.B. 
Published: September 2022

A first palaeomagnetic study has been carried out on a new section with a potential lower boundary interval for the Quaternary, Dolynske 3. Recently, the Matuyama-Brunhes boundary (at 780 ka) was detected in the adjacent section of Dolynske 2. The current study focuses on the hydromorphic palaeosols, loesses and pedosediments of the Bogdanivka to Kryzhanivka units. Taking into account previous palaeomagnetic data from other sections of the loess/soil formation of Ukraine, the Gauss-Matuyama boundary (2.58 Ma) could be expected to be at the top of the Bogdanivka soil unit. However, rock magnetic and magnetostratigraphic results from the Dolynske 3 section indicate an extremely low concentration of the ferrimagnetic minerals and the absence of a characteristic component of magnetisation due to the influence of hydromorphism. Only two samples from the Bogdanivka and Berezan units show a clearly defined reversed polarity; the rest of the samples were uninformative and were rejected from the interpretation. Given the unsuitability of hydromorphic palaeosols and loesses for magnetostratigraphic studies, the determination of the Gauss-Matuyama boundary requires additional, including methodological, research on other sections of Ukraine.
The stratigraphic completeness of the composite Dolynske section, its geomorphological location within the Pliocene Danube terraces and convenient geographical setting allow offering it for study as a reference section for the loess/soil formation in Europe. In addition, the Dolynske 3 section potentially may be regarded as a complete continental analogue of the Calabrian and Gelasian with both palaeomagnetic boundaries. Thus, the Dolynske section deserves research on many aspects of the Quaternary, including correlations of loess-palaeosol, alluvial and marine facies, the influence of hydromorphism on palaeomagnetic properties of rocks, «structures» of climatic rhythms in the Calabrian and Gelasian, as part of a separate international project.