bluuebunny/crossref_metadata_2025_split huggingface dataset:
Greybox model for multistage spray drying plants constrained to small datasets
Authors: Miklos Robert , Petersen Lars Norbert , Poulsen Niels Kjølstad , Utzen Christer , Jørgensen John Bagterp , Niemann Hans Henrik 
Published: April 2022

AbstractDynamic models of spray drying plants are required for many multivariable control strategies for spray dryers, for example, for model predictive control. Often, the model and its parameters are determined by fitting the model to experimental data. When the experimental data is generated, the experiments disturb normal production and introduce production losses. These losses increase the expenses for determining the model. Therefore, the experimentation time must be limited, which then limits the amount of data available for the model fitting. The limited amount of data restricts the complexity of the spray dryer model. In this article, we propose a greybox model with less complexity than the available models in the literature. The greybox model is derived by combining the process structure, physical relations and data from experimental data. The model is validated with experimental data from an MSD20 pilot plant. Further, the greybox model is compared to a model estimated by subspace identification. The comparison shows that the greybox model has a higher fit to the validation data than the subspace method.
Application of zebrafish in the study of craniomaxillofacial developmental anomalies
Authors: Li Kang , Fan Liwen , Tian Yu , Lou Shu , Li Dandan , Ma Lan , Wang Lin , Pan Yongchu 
Published: April 2022

AbstractCraniomaxillofacial developmental anomalies are one of the most prevalent congenital defects worldwide and could result from any disruption of normal development processes, which is generally influenced by interactions between genes and the environment. Currently, with the advances in genetic screening strategies, an increasing number of novel variants and their roles in orofacial diseases have been explored. Zebrafish is recognized as a powerful animal model, and its homologous genes and similar oral structure and development process provide an ideal platform for studying the contributions of genetic and environmental factors to human craniofacial malformations. Here, we reviewed zebrafish models for the study of craniomaxillofacial developmental anomalies, such as human nonsyndromic cleft lip with or without an affected palate and jaw and tooth developmental anomalies. Due to its potential for gene expression and regulation research, zebrafish may provide new perspectives for understanding craniomaxillofacial diseaseand its treatment.
Amorphous Silica‐Alumina as Suitable Catalyst for the Diels‐Alder Cycloaddition of 2,5‐Dimethylfuran and Ethylene to Biobased p‐Xylene
Authors: Coumans Ferdy J. A. G. , Demiröz Ezgi , Kosinov Nikolay , Hensen Emiel J. M. 
Published: April 2022

AbstractThe potential of amorphous silica‐alumina (ASA) to substitute zeolites (HBeta‐25) for the synthesis of p‐xylene via Diels‐Alder cycloaddition (DAC) of ethylene to 2,5‐dimethylfuran (2,5‐DMF) is investigated. ASA were prepared via homogeneous deposition‐precipitation of Al on SiO2. ASA shows good yields of p‐xylene (20–25 % after 18 hours) compared to bare silica and γ‐alumina. Brønsted acid sites (BAS) were identified as the active sites for the DAC reaction. The catalytic performance correlated strongly with the BAS concentration. Increasing the acidity of ASA is, however, limited by formation of agglomerated alumina‐type clusters at higher Al3+ content. While HBeta‐25 zeolite shows initially a slightly higher performance in terms of p‐xylene yield, ASA is the better catalyst upon calcination‐regeneration of the used catalyst. These results furthermore confirm that confinement in zeolite micropores is not a prerequisite for the DAC reaction between 2,5‐DMF and ethylene.
Design and robustness improvement of high‐performance LNA using 0.15 μm GaN technology for X‐band applications
Authors: Zafar Salahuddin , Cankaya Akoglu Busra , Aras Erdem , Yilmaz Dogan , Nawaz Muhammad Imran , Kashif Ahsanullah , Ozbay Ekmel 
Published: April 2022

SummaryIn this paper, we present a highly robust GaN‐based X‐band low‐noise amplifier (LNA) showing promising small‐signal and noise performance as well as good linearity. The LNA is fabricated using in‐house 0.15 μm AlGaN/GaN on a SiC HEMT process. Owing to the optimum choice of HEMT topologies and simultaneous matching technique, LNA achieves a noise figure better than 2 dB, output power at 1 dB gain compression higher than 19 dB, input and output reflection coefficients better than −9 and −11 dB, respectively. The small‐signal gain of LNA is more than 19 dB for the whole band, and NF has a minimum of 1.74 dB at 10.2 GHz. LNA obtains an OIP3 up to 34.2 dBm and survives input power as high as 42 dBm. Survivability is investigated in terms of gain compression and forward gate current. Reverse recovery time (RRT), a crucial parameter for radar front‐ends, is explored with respect to the RC time constant and trap phenomenon. The analysis shows that the significant contribution in RRT is due to traps while the RC time constant is in the nanoseconds range. Moreover, this study also addresses the requirement and choice of a DC gate feed resistor for the subsequent stages in a multi‐stage design. The size of the designed LNA chip is 3 mm
1.2 mm only.
Energy‐efficient alternating current computing‐enabled receiver design for K‐user interference channel simultaneous wireless information and power transfer networks
Authors: Sadik Eman , Shokair Mona , Elsabrouty Maha , Benaya Ahmed M. 
Published: April 2022

SummaryEnergy efficiency is one of the key challenges in fifth generation (5G) and beyond wireless communication systems. Recently, simultaneous wireless information and power transfer (SWIPT) systems are usually adopted to enhance energy efficiency. The harvested energy through power transfer is first rectified to generate the direct current (DC) voltage that is used to power the communication devices. This rectification reduces the energy efficiency due to losses in conversion to DC voltages. In this work, we consider integrated information decoding and energy harvesting receiver architecture through power splitting SWIPT network that enables alternating current (AC) computational logic. The AC computing method is used to supply the computing block of receivers to further enhance the energy efficiency. Multiuser multiple input single output (MISO) interference channel (IC) is considered, where receivers are required to compromise between quality of service (QoS) and energy consumption. The system sum rate is maximized under sum harvested energy and total transmit power constraints through joint beamforming and power splitting factors design. For the problem tractability in the proposed AC computing‐enabled receiver, standard beamforming schemes are deployed, namely, zero forcing (ZF), regularized zero forcing (RZF), maximum ratio transmission (MRT), and a hybrid scheme between MRT and ZF beamforming (MRT‐ZF). Moreover, the power splitting ratios design problem is transformed into a one dimension search problem. Simulation results show that different beamforming designs exhibit a great trade‐off between the achieved rate and the harvested energy.
Systematic review of neuroendocrine carcinomas of the oropharynx
Authors: Froehlich Michael H. , Shih Michael C. , Shehee Lindsey , Kompelli Anvesh R. , Aylward Alana , Nguyen Shaun A. , Kaczmar John M. , Nathan Cherie Ann , Day Terry , Neskey David M. 
Published: April 2022

AbstractData describing features and management of oropharyngeal neuroendocrine carcinomas (NEC) remain sparse. A systematic review was performed. Patients were stratified by treatment modality and examined for disease progression and survival outcomes. Ninety‐four patients from 50 publications were included. Average age at diagnosis was 59.7 years (range 14–83). 73.4% were male. Most studies did not document HPV status. Forty patients (85.1%) were p16 positive, and 34 (85.0%) were HPV‐ISH positive. Overall survival was 75.4% at 1 year, and 40.0% at 2 years. Of patients with locoregional disease, 33.8% developed distant metastasis. 12.5% of patients developed locoregional recurrence. Patients who developed distant metastases had worse overall survival (p = 0.0004). No significant difference was found between treatment modalities. Human papilloma virus may be associated with oropharyngeal NEC. Current treatments provide locoregional control, but distant metastases are common and confer low overall survival.
Time to four‐factor prothrombin complex concentrate administration decreased by presence of a 24/7 pharmacist in the emergency department
Authors: Kozlow Erin A. , Livings Sarah E. 
Published: April 2022

AbstractStudy objectiveThe objective of this study was to determine the impact of a 24/7 pharmacist (RPh) on time from order to the administration of four‐factor prothrombin concentrate complex (4F‐PCC) in the emergency department (ED).MethodsThis is a retrospective study that included patients who received 4F‐PCC in the ED for acute reversal of oral anticoagulation before and after the implementation of a 24/7 RPh. Patients for whom 4F‐PCC was ordered between May 1, 2014 and June 30, 2015 were in the pre‐RPh group and those between November 1, 2018 and December 31, 2019 were in the post‐RPh group. The primary end point was time from order to administration of 4F‐PCC. Time from arrival to administration of 4F‐PCC was also evaluated.ResultsOf 168 patients evaluated, 100 were included in the study (n = 33 pre‐RPh; n = 67 post‐RPh). The majority of patients were on warfarin (97.0% pre‐RPh and 73.1% post‐RPh) for atrial fibrillation. Both groups included trauma and intracranial hemorrhage patients. The mean time from order to 4F‐PCC administration was significantly shorter in the post‐RPh group (71.2 vs 35.2 minutes, P < .001, 95% confidence interval [CI] [27.013‐44.987]). In addition, the median time from arrival to 4F‐PCC administration was also shorter in the post‐RPh group (153 vs 106 minutes, P = .033).ConclusionsAt our institution, time from order, and from arrival, to administration of 4F‐PCC for reversal of oral anticoagulation in the setting of acute bleeding events in the ED was reduced by 36 minutes after the presence of a 24/7 pharmacist.
A guide for the pharmacist's role in insulin pump management during transitions of care
Authors: Clements Jennifer N. , Castelli Gregory , Meade Lisa T. , Odom Jessica M. 
Published: April 2022

AbstractIn the United States, approximately 12% of the adult population has a diagnosis of diabetes mellitus (DM). Persons with DM are at a higher risk of microvascular and macrovascular complications, as well as hospitalizations, compared with the general population. Over the years, technology for diabetes management has evolved as approximately 350 000 patients are using insulin pump therapy to manage DM. Insulin pump therapy has been shown to improve glycemic control and lower the risk of safety events, such as hypoglycemia. Some studies have shown high compliance with an insulin pump policy among staff members during a hospitalization for a patient with an insulin pump. Other studies have shown improved glycemic control during hospitalization for patients who were managed on an insulin pump from an outpatient endocrinology clinic prior to admission. However, none of the studies involved pharmacy‐ or pharmacist‐led service for insulin pump management during transitions of care. Therefore, we defined the responsibilities of clinical pharmacists, in various roles, regarding insulin pump management in transitions of care. The purpose of this paper is to summarize current evidence for continuous subcutaneous insulin infusion (CSII) in transitions of care, including the use of insulin pumps in the hospital. Opportunities for a pharmacist's role in policies and procedures are also outlined, along with training of clinical pharmacists in this area of practice.
The accuracy of ICD‐CM codes to identify thromboembolic events for clinical outcomes research
Authors: Kelly Gregory F. , Makhoul Therese , Zammit Christopher G. , Jones Courtney M.C. , Acquisto Nicole M. 
Published: April 2022

AbstractIntroductionResearch using electronic health care databases continues to grow given widespread adoption of electronic health records (EHR). As manual record review is often not feasible with the increasing amount of data, use of International Statistical Classification of Diseases and Related Health Problems‐Clinical Modification (ICD‐CM) codes are a method of capturing the study population or abstracting outcomes. The accuracy of ICD‐CM coding and methodological validity of its use in medical research has been variable.ObjectivesTo compare the performance of ICD‐CM code data to pharmacist EHR review to identify patients that developed an in‐hospital thromboembolic event (TE) following four‐factor prothrombin complex concentrate (4F‐PCC) administration for anticoagulation reversal.MethodsA total of 337 patients were evaluated for TE occurrence following 4F‐PCC administration by two separate methods; discharge ICD‐CM code capture and pharmacist EHR review. To adjudicate ICD‐CM code and/or pharmacist‐identified TE cases, a blinded physician investigator reviewed the EHR and categorized the patient as having a TE or not based on extensive study definitions. To quantify the accuracy of ICD‐CM coding for patient outcome event and pharmacist investigator EHR review, positive predictive values (PPV) were calculated using physician review as the gold standard.ResultsA total of 76 cases were identified: 57 cases were identified by ICD‐CM codes only, 13 by pharmacist review only, and six by both ICD‐CM code and pharmacist review. Upon review by the physician investigator, 27 (35.5%) were identified as having an in‐hospital TE. There was a high degree of agreement between physician and pharmacist identification (88.2%). ICD‐CM code data demonstrated low PPV (22.2%) while pharmacist EHR review demonstrated high PPV (94.7%) for the identification of TE.ConclusionICD‐CM code data may be helpful in identifying study patients in large datasets, however low PPV for identification of TE requires clinician validation before acceptance as outcome data in clinical research.
Pharmacist led vaccination rates in opioid addicted obstetric patients
Authors: Forinash Alicia B. , Yancey Abigail M. , Shyken Jaye 
Published: April 2022

AbstractObjectiveTo evaluate whether patients seen at the Women's and Infants Substance Help Center (WISH) are in compliance with the 2016 Advisory Committee on Immunization Practices (ACIP) recommendations for influenza, tetanus/diphtheria/pertussis (Tdap), pneumococcal‐23, hepatitis A, hepatitis B, and human papillomavirus (HPV) vaccines.MethodsIn a retrospective cross‐section chart review, all patients with at least two WISH visits from September 1, 2014 to January 22, 2017 were included in the analysis. The primary objective evaluated compliance with ACIP recommendations. Data extraction included baseline demographics, patient‐specific vaccine indications, and vaccine history.ResultsNinety‐nine patients receiving buprenorphine (n = 80), methadone (n = 14), or no therapy (n = 5) from September 1, 2014 to January 22, 2017 were included. On average, patients were 28 years old and had the first visit at 19 gestational weeks (range 6‐35). Overall, WISH vaccination compliance was high for influenza (66%) and Tdap (86%) as well as the initial doses of hepatitis A (80%), hepatitis B (77%), and HPV (46%) vaccines. No difference was found between patients receiving buprenorphine and methadone. Patients who had at least 1 pharmacist consultation (n = 90) had significantly higher compliance with the initial doses of hepatitis A (92.1% vs 22.2%, P < .0001) and hepatitis B (86.4% vs 11.1%, P < .0001), and influenza vaccines (71.6% vs 33.3%, P < .0001) compared to those who did not (n = 9). Common reasons for vaccine non‐compliance were patient refusal, did not return to the clinic, or missed opportunity by the non‐pharmacist healthcare professional.ConclusionsOverall clinic vaccination rates were high and implies that pharmacy intervention significantly increased administration rates for hepatitis A, hepatitis B, and influenza vaccines.Clinical trial registration: ClinicalTrials.gov, www.clinicaltrials.gov, NCT 03039725.
Patient‐reported medication adherence and tolerability: Results of a prospective observational study
Authors: Keys Alison E , Pilch Nicole A. , Perez Caroline , Patel Neha , Meadows Holly , Fleming James N. , Taber David J. 
Published: April 2022

AbstractPurposeMedication nonadherence (MNA) is a major contributor to late allograft loss in transplantation. Immunosuppression therapy is highly effective at preventing rejection yet presents a substantial toxicity burden. There is limited data assessing the correlation between MNA and tolerability in transplant.MethodsThis was a single‐center prospective observational longitudinal study including adult transplant recipients. Consenting transplant patients were administered a survey assessing adherence (Morisky Med Adherence Survey, MMAS) and a medication tolerability assessment (modified MTSOSD‐59R). Participants were emailed surveys every 2 months (repeated measures) for a maximum of 36‐months. Generalized linear models (logistic and Gaussian) were used for analyses, accounting for correlation by repeated measures and time.ResultsThere were 472 assessments completed in 268 transplant recipients. Mean post‐transplant time was 4.0 ± 5.4 years; medium or high adherence was reported in 77.4% of responses. Medication side effect burden improved over time, while medication adherence had a decreasing trend over time. Self‐reported medication side effect burden significantly correlated with medication adherence. For every one‐point increase in side effect burden there was a 1.3% corresponding decrease in odds of reporting medium to high adherence. Those with higher than average medication side effect burden had a 57% lower odds of reporting medium to high adherence.ConclusionMNA is common in transplant recipients, regardless of transplant type. Self‐reported medication side effect burden is significantly correlated with medication adherence, offering a potential area of intervention for clinicians to improve non‐adherence rates.
A prescription for an outpatient parenteral antimicrobial therapy (OPAT) rotation for pharmacy residents
Authors: Mahoney Monica V. , Alexander Bryan T. , Rivera Christina G. , Ryan Keenan L. , Childs‐Kean Lindsey M. 
Published: April 2022

AbstractBackgroundOutpatient parenteral antimicrobial therapy (OPAT) is an emerging area for pharmacist involvement. However, many residency training programs do not offer OPAT rotation opportunities for their residents.ObjectiveTo provide a blueprint for residency programs hoping to offer OPAT rotations for postgraduate year 1 (PGY1) or postgraduate year 2 (PGY2) pharmacy residents.ResultsAs a rotation area with copious patient interaction, there are many unique accreditation objectives that can be taught and evaluated in an OPAT rotation. The OPAT rotation format may be longitudinal or block. Activities the resident can complete include predischarge evaluation, patient counseling, medication selection, physical examinations, laboratory monitoring, patient presentations, documentation, projects, and educational presentations.ConclusionOPAT rotations provide many opportunities for residents to satisfy the objectives required in residency training.
Appointment attendance and patient perception of drive‐up INR testing in a rural anticoagulation clinic during the COVID‐19 pandemic
Authors: Zobeck Bryan , Carson Erin , MacDowell Martin , Hunt Aaron , Reeder Austin 
Published: April 2022

AbstractIntroductionThe Anticoagulation Forum and Centers for Disease Control and Prevention (CDC) recommend drive‐up international normalized ratio (INR) testing to combat INR non‐adherence and increase safety during the coronavirus disease 2019 (COVID‐19) pandemic. Patient perceptions and impact on attendance have not been studied.ObjectiveTo assess appointment volume and patient perception after initiation of drive‐up INR testing in a rural pharmacist‐managed anticoagulation clinic.MethodsThis cross‐sectional cohort survey study offered each patient attending the anticoagulation clinic via drive‐up or in‐office visit a survey between May 27 and July 2, 2020. Patients testing off‐site were excluded. Study end points included monthly patient volume, visit type preference, testing barriers, desired drive‐up duration, and overall clinic satisfaction. Clinic appointment volume from October 2019 to June 2020 was collected retrospectively through a schedule review.ResultsSixty‐four (80%) of 80 surveys offered were completed: 46.6% of respondents preferred drive‐up testing, 26.7% indifferent, and 26.7% preferred in‐office visits; 38.7% of respondents indicated a greater likelihood of continuing routine INR monitoring via drive‐up testing. Of the respondents completing the survey curbside, 46% and 27% of respondents identified reduced COVID‐19 transmission risk and ease of transportation as benefits of drive‐up INR testing, respectively. March and April clinic volumes were 19% and 22% below average, respectively, returning to baseline after drive‐up testing was implemented. Clinic rating before and after drive‐up testing remained high at 2.75 on a scale of 0‐3. While infection risk was identified as the biggest barrier to care by 32.8% of respondents, 59.3% of all respondents wanted drive‐up testing to continue indefinitely.ConclusionsDrive‐up INR testing improves patient attendance during the COVID‐19 pandemic. Patient perception of drive‐up testing is positive. About 46% of respondents preferred drive‐up INR testing with telehealth follow‐up and 59.3% of respondents want drive‐up testing to continue indefinitely, which suggests this approach to INR testing as a potential method to allay barriers to routine monitoring beyond the scope of the pandemic.
Disparities in gender distribution within editorial boards of pharmacy journals
Authors: Awad Nadia I. 
Published: April 2022

AbstractIntroductionSpecialties within the field of science, technology, engineering, and mathematics (STEM) have demonstrated that disparities exist within editorial boards of their respective professional journals. However, limited data of this observation exists within the scope of pharmacy practice. The purpose of this study was to evaluate the distribution of gender across editorial board members of several pharmacy journals.MethodsIn this cross‐sectional study, a total of 20 pharmacy journals were selected, using a combination of several factors including the SCImago Journal and Country Rank as of March 2019 and prominence across various organizations within the discipline. Publicly available information from the official website of each respective journal was evaluated to determine the proportion of males and females serving as members of the editorial board. An Internet search was conducted to confirm this demographic for those individuals where gender could not be determined. Descriptive statistics were used to quantify qualitative variables.ResultsData were sufficient to determine the gender of editorial members in all 20 pharmacy journals. Eight hundred and thirteen individuals were identified to serve on editorial boards, of which 326 (40%) were female, with a range of 8% to 63% per journal. Only four journals (20%) had a female editor‐in‐chief.ConclusionDisparities in gender distribution exist among editorial boards of pharmacy journals. Future efforts should focus on increasing the proportion of women serving as both members of the editorial board and as editor‐in‐chief to drive diversity, minimize implicit bias, and possibly enhance the content and quality of publications.