bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depression and anxiety in colorectal cancer patients: Ties to pain, fatigue, and inflammation
Authors: Renna Megan E. , Shrout M. Rosie , Madison Annelise A. , Alfano Catherine M. , Povoski Stephen P. , Lipari Adele M. , Carson William E. , Malarkey William B. , Kiecolt‐Glaser Janice K. 
Published: June 2022

AbstractObjectiveColorectal cancer poses a significant threat to both psychological and physical health. This study examined relationships between anxiety and depressive symptoms with pain, fatigue, and inflammation among colorectal patients.MethodsColorectal cancer patients (n = 88, stages 0‐IV) completed a laboratory‐based study visit before undergoing adjuvant cancer treatment. Patients completed questionnaires assessing depressive, anxiety, pain, and fatigue symptoms. A blood sample was also collected to measure c‐reactive protein (CRP). Analyses controlled for age, sex, cancer stage, body mass index (BMI), and menopause status.ResultsMultiple linear regression analyses showed colorectal patients with higher depressive and anxiety symptoms had greater pain, fatigue, and CRP (ps < 0.03). Approximately one‐third of patients with clinically significant depressive (CESD >16) and anxiety symptoms (BAI >16) also had clinically‐elevated levels of CRP (>3 mg/L) (ps = 0.02).ConclusionThese results extend findings from other cancer subgroups showing heightened symptom burden among patients with depression and anxiety. They also highlight the detrimental role that elevated anxiety and depressive symptoms may play in the physical and biological side effects associated with colorectal cancer.
The prevalence of anxiety and depression in patients with ostomy: A systematic review and meta‐analysis
Authors: Farahani Mansoureh Ashghali , Sargolzaei Mohammad Sadegh , Shariatpanahi Shabnam , Dehkordi Ali Hasanpour , Dalvand Pegah , Heidari‐Beni Farshad 
Published: June 2022

AbstractAimThe prevalence of anxiety and depression in patients with ostomy is reported differently. The aim of this systematic review and meta‐analysis is to estimate the global prevalence of anxiety and depression in patients with ostomy.MethodA systematic search of Embase, Proquest, Scopus, PubMed and Web of Science (ISI) databases was conducted from January 1990 up to 5 May 2021. A total of 3392 records were retrieved and 18 studies were ultimately included. Two reviewers independently assessed full‐text of articles according to predefined criteria. A random‐effects model was used to estimate the prevalence of anxiety and depression and I2 index was used to assess the heterogeneity of the studies. Subgroup analysis and mea‐regression were conducted to explore potential sources of heterogeneity. The review protocol is registered in PROSPERO and is available online. Data analysis was performed using R software version 4.3.1.ResultsIn this study, the pooled prevalence of anxiety was 47.60% (95% CI, 29.94–65.26) and the pooled prevalence of depression was 38.86% (95% CI, 29.29–48.43). The subgroup analysis showed the prevalence of anxiety and depression in different regions was not significantly different (p = 0.854, p = 0.143 respectively). Nevertheless, the highest and lowest prevalence of anxiety were in Asia and the America 51.79% and 32.69%, respectively and the highest and lowest prevalence depression were in Asia with 49.80% and Europe with 26.77%, respectively.ConclusionThe finding of this study showed the global prevalence of anxiety and depression in patients with ostomy is high. Therefore, all health care providers who deal with these patients should use appropriate psychological strategies, techniques and interventions to reduce anxiety and depression in these patients.
pH‐Responsive Pt@mSiO2@CaP Core–Shell Nanoplatforms for Synergistic Chemo‐ and Photothermal Therapy
Authors: Wang Junlei , Li Danyang , Xu Qing , Wang Haijiao , Liang Chengfeng , Zhang Xinyue , Wang Shi‐Bin , Chen Aizheng , Jiang Nina 
Published: June 2022

AbstractPlatinum/mesoporous silica/amorphous calcium phosphate core–shell nanoplatforms (Pt@mSiO2@CaP) are prepared for near‐infrared light‐triggered photothermal therapy and pH‐responsive chemotherapy. In the core–shell nanoplatforms, the Pt cores with flower‐like shapes exhibit broadband near‐infrared light absorption, which endows the nanoplatforms with a remarkable photothermal performance under 808 nm laser irradiation. The mesoporous SiO2 intermediate layers offer accessible channels for drug loading. The drug release from the SiO2 intermediate layers is driven by the acidic environment of tumor cells owing to the biodegradability of the CaP outermost layer. The hyperthermia generated by the Pt cores accelerates the drug release, thereby increasing intracellular drug concentration. A marked synergistic therapeutic effect of chemo‐ and photothermal therapy in vitro is demonstrated using the DOX‐loaded Pt@mSiO2@CaP. The design of the three‐layer core–shell nanoplatforms points out a way to the synthesis of multifunctional nanomaterials and extends to theranostic applications.
Effective dominance and redundant killing of single‐ and dual‐gene resistant populations of Helicoverpa zea on pyramided Bt corn and cotton
Authors: Santiago‐González José C , Kerns David L , Head Graham P , Yang Fei 
Published: June 2022

AbstractBACKGROUNDPyramided Bacillus thuringiensis (Bt) crops producing multiple Bt proteins with different modes of action are widely planted in the United States. Helicoverpa zea is a major target pest of pyramided Bt crops and has evolved practical resistance to both Cry1 and Cry2 proteins in some regions of U.S. However, little information is available regarding redundant killing and the dominance of resistance for insects possessing multiple resistance on pyramided Bt crops. In this study, we evaluated redundant killing and the dominance of resistance for H. zea strains resistant to Cry1 or Cry1 + Cry2 on pyramided Bt corn and cotton.RESULTSWe found that the Cry1‐resistant H. zea was incompletely dominant on Cry1Ac + Cry1F cotton. Pyramided crops producing Cry2 and/or Vip3Aa proteins showed a complete redundant killing against the Cry1‐resistant H. zea. The Cry1 + Cry2‐resistant H. zea displayed incompletely recessive to completely dominant resistance on pyramided Bt crops containing Cry1 and/or Cry2 proteins. The redundant killing was complete for the Cry1 + Cry2‐resistant H. zea on pyramided Bt crops producing Vip3Aa protein.CONCLUSIONThe dominant resistance of Cry1 and Cry2 in H. zea on pyramided Bt crops deviates from the assumption of functionally recessive resistance underlying the high‐dose refuge strategy. However, the assumptions of complete redundant killing are achieved for both Cry1‐ and Cry1 + Cry2‐resistant H. zea on pyramided Bt crops. These results suggest that the pyramided strategy could be valuable for increasing the durability of Bt technology for managing H. zea, a pest with inherently low susceptibility against Cry proteins. © 2022 Society of Chemical Industry.
The role of macrophages in right ventricular remodeling in experimental pulmonary hypertension
Authors: Gu Sue , Mickael Claudia , Kumar Rahul , Lee Michael H. , Sanders Linda , Kassa Biruk , Harral Julie , Williams Jason , Hansen Kirk C. , Stenmark Kurt R. , Tuder Rubin M. , Graham Brian B. 
Published: June 2022

AbstractRight ventricular (RV) failure is the primary cause of death in pulmonary hypertension (PH), but the mechanisms of RV failure are not well understood. We hypothesized macrophages in the RV contribute to the RV response in PH. We induced PH in mice with hypoxia (FiO2 10%) and Schistosoma mansoni exposure, and in rats with SU5416‐hypoxia. We quantified cardiac macrophages in mice using flow cytometry. Parabiosis between congenic CD45.1/.2 mice or Cx3cr1‐green fluorescent protein and wild‐type mice was used to quantify circulation‐derived macrophages in experimental PH conditions. We administered clodronate liposomes to Sugen hypoxia (SU‐Hx) exposed rats to deplete macrophages and evaluated the effect on the extracellular matrix (ECM) and capillary network in the RV. In hypoxia exposed mice, the overall number of macrophages did not significantly change but two macrophage subpopulations increased. Parabiosis identified populations of RV macrophages that at steady state is derived from the circulation, with one subpopulation that significantly increased with PH stimuli. Clodronate treatment of SU‐Hx rats resulted in a change in the RV ECM, without altering the RV vasculature, and correlated with improved RV function. Populations of RV macrophages increase and contribute to RV remodeling in PH, including through regulation of the RV ECM.
New impact diagnostics for cross‐validation of different observation types
Authors: Stiller Olaf 
Published: June 2022

AbstractNew cross‐validation diagnostics have been derived by further partitioning well‐established impact diagnostics. They are related to consistency relations, the most prominent of which indicates whether the first‐guess departures of a given observation type pull the model state into the direction of the verifying data (when processed with the ensemble estimated model error covariances). Alternatively, this can be regarded as cross‐validation between model error covariance estimates from the ensemble (which are used in the data assimilation system) and estimates diagnosed directly from the observations. A statistical cross‐validation tool has been developed that includes an indicator of statistical significance as well as a normalization that makes the statistical comparison largely independent from the total number of data and the closeness of their collocation. We also present a version of these diagnostics related to single‐observation experiments that exploits the same consistency relations but is easier to compute. Diagnostics computed within the Deutscher Wetterdienst's localized ensemble transform Kalman filter (LETKF) are presented for various kinds of bins. Results from well‐established in‐situ measurements are taken as a benchmark for more complex observations. Good agreement is found for radio‐occultation bending angle measurements, whereas atmospheric motion vectors are generally also beneficial but substantially less optimal than the corresponding in‐situ measurements. This is consistent with reported atmospheric motion vector height assignment problems. To illustrate its potential, a recent example is given where the method allowed identifying bias problems of a subgroup of aircraft measurements.Another diagnostic relationship compares the information content of the analysis increments with a theoretical optimum. From this, the information content of the LETKF increments is found to be considerably lower than those of the deterministic hybrid ensemble–variational system, which is consistent with the LETKF's limitation to the comparably low‐dimensional ensemble space for finding the optimal analysis.
Cover crop monocultures and mixtures affect soil health indicators and crop yield in the southeast United States
Authors: Decker Hannah L. , Gamble Audrey V. , Balkcom Kipling S. , Johnson Anna M. , Hull Noah R. 
Published: June 2022

AbstractThe southeastern United States has a long history of soil degradation due to intensive agriculture and climatic factors. Conservation management practices such as cover cropping aim to improve soil productivity and restore soil health. Our objectives were to evaluate the performance of cover crops and their short‐term effects on soil health indicators for two southeastern soil types. Cover crop experiments were conducted at the Wiregrass (WREC) and Tennessee Valley (TVREC) Research and Extension Centers in Alabama from 2017 to 2021. Cover crop treatments included winter fallow, monocultures, and two‐ and three‐way mixtures of cereal rye (Secale cereale L.), crimson clover (Trifolium incarnatum L.), and forage radish (Raphanus sativus L.) preceding a cotton (Gossypium hirsutum L.)–legume {peanut [Arachis hypogaea L.] or soybean [Glycine max (L.) Merr.]} cash crop rotation. At TVREC, aboveground biomass for both rye and clover were greater than radish. All cover crops, except the radish monoculture, increased soil organic carbon (SOC) 19–30% in the top 5 cm at TVREC compared with winter fallow. Similarly, some cover crop treatments increased permanganate oxidizable carbon (POXC) compared with the fallow control. However, this effect was not observed at WREC. Cover crops did not produce many meaningful aggregate stability differences at either location. Treatments containing rye or clover decreased soil strength. by 14–22% at TVREC after 4 yr of cover crop utilization. Short‐term cover crop use improved selected soil health indicators and reversed soil degradation at one location evaluated, but these benefits were dependent on soil type and cover crop selection.
Soil mean‐weight diameter and stability index under contrasting tillage systems for cotton production in North Carolina
Authors: Franzluebbers Alan J. 
Published: June 2022

AbstractCoarse‐textured soils are typically not highly aggregated due to low surface reactivity of sand‐sized grains. However, soil erosion and surface sealing can still be a concern from frequently tilled soil in relatively flat landscapes of the Coastal Plain and Flatwoods of the southeastern United States. Soil at 0‐to‐10‐cm depth was sampled from 120 randomly chosen cotton (Gossypium hirsutum L.) fields in North Carolina, which could be separated into three categories of tillage system: frequent disk tillage, rotated conservation and disk tillage, and continuous conservation tillage. This study assessed soil stability index derived using (a) mean‐weight diameter (MWD) following water immersion and oscillation for 10 min relative to that of (b) MWD following dry sieving of soil. This whole‐soil analysis had significant variation in soil stability index (interquartile range of 0.58 to 0.95 mm mm–1) along a sand concentration gradient, but that was differentiated by tillage system. The strongest association of MWD from dry‐stable crumbs (r = .71, p < .001) and of MWD from water‐stable crumbs (r = .65, p < .001) occurred with soil‐test biological activity, suggesting that organic C resources near the soil surface with continuous conservation tillage promoted both biological activity and soil stability. Physical manipulation of soil by biota (i.e., fauna, microbes, and roots) into water‐stable crumbs was a consequence of continuously undisturbed organic C resources near the soil surface, which also led to greater soil‐test biological activity and net N mineralization.
Fear of cancer recurrence as a pathway from fatigue to psychological distress in mothers who are breast cancer survivors
Authors: Kuswanto Carissa Nadia , Sharp Jessica , Stafford Lesley , Schofield Penelope 
Published: June 2022

AbstractFatigue is prevalent and pervasive among breast cancer survivors. Mothers are particularly susceptible to fatigue due to the ongoing demands of their caring role. While fatigue has been associated with psychological distress in prior research, the pathway by which fatigue translates into psychological distress is unclear. Given the theoretical and empirical links between fatigue, fear of cancer recurrence (FCR) and psychological distress, the role of FCR in mediating the relationship between fatigue and psychological distress in mothers who are breast cancer survivors was investigated. Ninety‐two mothers who were breast cancer survivors completed the Depression, Anxiety and Stress Scale, PROMIS‐Cancer Fatigue Short Form and Concerns About Cancer Recurrence scale in an online survey. Mediation analysis via PROCESS was used to examine whether fatigue predicted depression, anxiety or stress through FCR. Fear of cancer recurrence mediated the relationships between fatigue and anxiety and fatigue and stress, while fatigue directly predicted depression. This study highlights FCR as a potential pathway to anxiety and stress in response to ongoing fatigue, and as a mechanism of action to reduce psychological distress among mothers who are breast cancer survivors. Future research examining this pathway from fatigue to psychological distress should also explore the nature of mothers' fears about their cancer recurring.
Siglec15 Checkpoint Blockade for Simultaneous Immunochemotherapy and Osteolysis Inhibition in Lung Adenocarcinoma Spinal Metastasis via a Hollow Nanoplatform
Authors: Liang Haifeng , Zhou Lei , Hu Zhichao , Ge Yuxiang , Zhang Taiwei , Chen Qing , Wang Ben , Lu Shunyi , Ding Wang , Dong Jian , Xue Fengfeng , Jiang Libo 
Published: June 2022

AbstractLow responsiveness to anti‐programmed death‐1/programmed death‐ligand 1 (anti‐PD‐1/PD‐L1) for solid tumors indicates the presence of other immunosuppressive pathways. Siglec15, a newly discovered immune checkpoint, has been reported to repress immune responses in the tumor microenvironment (TME) and regulate osteoclast differentiation. However, the role of Siglec15 in the treatment for bone metastasis remains unclear. Herein, Siglec15 shows significantly higher expression in lung adenocarcinoma spinal metastasis (LUAD‐SM) than in para‐cancerous spinal tissues and primary LUAD. Subsequently, a TME‐responsive hollow MnO2 nanoplatform (H‐M) loaded with Siglec15 siRNA and cisplatin (H‐M@siS15/Cis) is developed, and the surface is modified with an aspartic acid octapeptide (Asp8), thus allowing H‐M to target spinal metastasis. High drug‐loading capacity, good biocompatibility, effective tumor accumulation, and efficient Siglec15 silencing are demonstrated. Furthermore, the nanoparticles could reverse immunosuppression caused by tumor cells and tumor‐associated macrophages (TAMs) and inhibit osteoclast differentiation via Siglec15 downregulation in vitro. In a LUAD‐SM mouse model, H‐M@siS15/Cis‐Asp8 exhibits superior therapeutic efficacy via synergetic immunochemotherapy and osteolysis inhibition. Taken together, this single nanoplatform reveals the therapeutic potential of the new immune checkpoint Siglec15 in LUAD‐SM and provides a strategy to treat this disease.
Does quitting smoking increase obesity? Evidence that accounts for misreporting
Authors: Tchernis Rusty , Teltser Keith , Teotia Arjun 
Published: June 2022

AbstractStudying the relationship between smoking and obesity, the leading causes of preventable deaths in the U.S., helps assess the potential unintended consequences of policy efforts to reduce smoking. Because existing literature is mixed among studies using experimental and observational data, we investigate the role of misreporting in observational data. We use the Behavioral Risk Factor Surveillance System, cigarette taxes to instrument for smoking, and survey completion to instrument for misreporting. Starting with the seminal two‐stage least squares (2SLS) approach, our estimates similarly suggest quitting smoking substantially reduces body mass index (BMI). However, the relationship between cigarette taxes and BMI has shrunk over time, and the 2SLS estimates are sensitive to specification, functional form, and misreporting. Accounting for misreporting using the 2‐step estimator from Nguimkeu et al. (2019) yields estimates consistent with the experimental literature; quitting smoking modestly increases BMI. Our preferred estimate suggests reduced smoking accounts for 6% of the concurrent rise in obesity.
Processing of Starch in Deep Eutectic Solvent
Authors: Deng Xiaonan , Zhang Mengnan , Liu Kun , Pu Mingdong , Han Xiaozhao 
Published: June 2022

AbstractThe deep eutectic solvent of [choline chloride (ChCl)] [ethylene glycol (EG)] is demonstrated to be an effective non‐destructive solvent for starch processing. The pre‐gelatinized starch samples are prepared by its gelatinization, treatment, and re‐crystallization in this deep eutectic solvent and characterized by differential scanning calorimetry (DSC), gel permeation chromatography (GPC), Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance spectroscopy (H‐NMR), X‐ray diffraction analyses (XRD), and scanning electron microscopy (SEM) tests. The gelatinization temperature of starch in the deep eutectic solvent of [choline chloride] [ethylene glycol] is measured using a DSC method. Compared to the native starch sample, slight increases in molecular weights and decreases in molecular weight distribution of the recovered starch samples are observed. The similar FTIR and H‐NMR spectra of the native starch and recovered starch samples suggest no reaction and variation in chemical structure during the processing. The XRD and DSC tests show that the strong micro‐granular crystalline structure of the native corn starch is destroyed during the gelatinization and treatment in the DES while new weak crystalline structure is formed during the re‐crystallization.
Study on the Preparation and Digestibility of Malic Acid Sweet Potato Starch Ester under Microwave Assistance
Authors: Wang Wei , Liu Tiantian , Zhi Wenli , Zhou Yu , Hu Aijun , Zheng Jie 
Published: June 2022

AbstractIn this paper, malic acid sweet potato starch ester (MSE) is prepared by the microwave assisted l‐malic acid method, and its digestibility is studied. Through a response surface methodology based on a Box‐Behnken design (BBD), the optimum conditions for the preparation of MSE are obtained as follows: mass ratio (mL‐malic acid: mstarch) of 0.81, pH value of 1.21, microwave time of 6.8 min, and microwave power of 435 W, respectively. Under these conditions, the degree of substitution of MSE is 0.0712. In addition, the freeze‐thaw stability, transparency, and solubility of the MSE are better than the native starch. Microwave assisted l‐malic acid treatment significantly increases the resistant starch (RS) content in starch sample. FTIR reveals a new characteristic peak near 1735 cm–1 in MSE samples, and the relative crystallinity decreases from 33.03% to 21.18%. Differential scanning calorimetry results show that the endothermic peak of MSE decreases. These results indicate that microwave‐assisted l‐malic acid can significantly change the physicochemical properties of sweet potato starch, and it is an effective method for the preparation of RS with heat‐stable resistance.
Progress of NiO‐Based Anodes for High‐Performance Li‐Ion Batteries
Authors: Zhou Guolang , Ding Wenhao , Guan Yu , Wang Tianshi , Liu Cheng , Zhang Lili , Yin Jingzhou , Fu Yongsheng 
Published: June 2022

AbstractRechargeable lithium‐ion batteries (LIBs) are of great significance to the development of renewable energy. The traditional graphite anode is gradually unable to meet increasing demands for high energy density and power density due to its low theoretical capacity. NiO has gained considerable attention because of its high theoretical capacity, low toxicity, and stable chemical properties. This review summarizes the research progress of NiO‐based nanomaterials in LIBs and centers on the electrochemical reaction mechanism, synthesis methods, and strategies for improving the electrochemical properties of NiO anodes. The results demonstrate that the electrochemical characteristics highly depend on the synthesis method, morphology, surface area, conductive substrate, etc. Compared with pure NiO, NiO‐based composites including NiO/carbon‐based materials and NiO/metal oxide often present higher capacity and cycle stability. Furthermore, challenges and future perspectives of NiO‐based anodes are also discussed.