bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Lembar Kerja Siswa Berbasis Teams Games Tournament Pada Materi Keanekaragaman Hayati Di Indonesia Kelas X Sma Negeri 1 Wewewa Selatan
Authors: Bora Ayuprames Hari , Sari Nila Kartika 
Published: December 2022

The purpose of this research is to find out the feasibility of student worksheets (lks) based on team games tournament (tgt so that student worksheet products made can be used in the process of teaching and learning in class, in this study using thiagarajan et al' 4-d method (1974) which consists of 4 stages namely define, design, develop, and disseminate conducted in this study is limited to the stage of develop. the subjects of the study are lecturer validators, teacher validators, and test limitations in class x students. the number of students involved in this study as many as 20 people, this research can be obtained data through several validation techniques. The data obtained is the result of various validations then processed / analyzed with a likert scale with a score criteria of 1: not good 2: less good3: good 4: very good. through validation results from material experts get assessments with an average result of 75% with decent categories, media expert validation gets an assessment with an average result of 65.45% with a decent category, validation biology teachers get an assessment with an average result of 70.65% with a decent category and a student readability test student worksheet (lks) 7 question options get an assessment and an average result of 39.5 with a very decent category. it is known that the torunamen team game (tgt) based student worksheet (lks) is worth developing and using.
Hambatan Siswa Kelas VIII di SMPN 4 Pacar dalam Mempelajari Mata Pelajaran Biologi disaat Pandemic Covid-19
Authors: Jonsi Evaristus Regavit , Riyanto Riyanto 
Published: December 2022

This study aims to explain in detail how the obstacles experienced by class VIII students in learning during the Covid-19 pandemic. This study uses a qualitative approach. Because this study explains the phenomena that occur in the field by collecting data obtained from research informants. The data collection technique used in this research is interview, where the researcher conducts direct interviews with research informants, by means of question and answer while face to face between interviewers and research informants. The type of interview used is an unstructured interview. Documentation is a way of collecting data that produces important notes related to the problem under study, so that complete, valid and not based on estimates will be obtained.
The results of the study found by researchers were the obstacles experienced by students, namely the lack of a network, the ability of parents to be categorized as economically weak, only some students who had smartphones, and the absence of electricity facilities. Concrete steps taken by educational institutions are, continue to carry out the process of teaching and learning activities but by having to follow the health protocol that has been made by the government. This research is expected to be an evaluation of various parties in conducting online learning in junior high schools, especially those involving obstacles in them, this research is also expected to be a study material for other researchers in analyzing and knowing student learning barriers in online learning during an emergency in high school first.
Klasifikasi Penentuan skema Uji Sertifikasi di LSP UDINUS bagi mahasiswa Progrdi Sistem Informasi UDINUS dengan Algoritma Decision Tree (C4.5)
Authors: Winarno Agus , Warsito Budi , Wibowo Adi , Zeniarja Junta 
Published: December 2022

AbstrakPenerapan Algoritma Decision Tree (C4.5) dan Eksperimen proses klasifikasi dilakukan menggunakan data nilai mahasiswa program studi S1 Universitas Dian Nuswantoro dengan 120.232 dataset menggunakan metode klasifikasi dengan Algoritma Decision Tree menghasilkan 99,99 % dan menghasilkan 7 klasifikasi dengan rekomendasi ntuk pelatihan dan uji sertifikasi di Lembaga sertifikasi profesi UDINUS pada 5 klasifikasi yaitu klasifikasi pred C sejumlah 2.355 data, pred BC sejumlah 4.633, pred B sejumlah 38.420 , pred AB sejumlah 33.414 dan pred A sejumlah 37.230 dan 2 klasifikasi yang tidak direkomendasikan yaitu klasifikasi pred D 1.440 dan pred E sejumlah 2.784 yang memberikan penyesuaian kurikulum pendidikan di Universitas Dian Nuswantoro dengan lembaga Sertifikasi dan Kebutuhan pekerjan. Kata Kunci: Sertifikasi, klasifikasi, mahasiswa, Tree Algorithm, rekomendasi
Association of aortic arch and aortic valve calcifications with cardiovascular risk in patients on maintenance hemodialysis
Authors: Liao Min-Tser , Chao Chia-Ter , Wu Chung-Kuan 
Published: December 2022

IntroductionThis study aimed to investigate the association of aortic arch calcification (AoAC) and aortic valve calcification (AVC) with major adverse cardiovascular events (MACE) and cardiovascular and all-cause mortality in patients on maintenance hemodialysis (MHD).MethodsThis study enrolled 297 adult patients with end-stage kidney disease who were on MHD. They were divided into those with an AoAC score &lt;2 without AVC (n = 70, 23.6%), those with an AoAC score &lt;2 with AVC (n = 96, 32.3%), and those with an AoAC score ≥2 regardless of AVC status (n = 131, 44.1%). We analyzed the risks of MACE, cardiovascular and overall mortality among the three groups using Cox proportional hazard analyses. Survival probabilities were estimated using the log-rank test via the Kaplan–Meier method.ResultsKaplan–Meier analysis revealed that the MACE-free rate and the survival rates of cardiovascular and overall mortality were significantly higher in adult chronic hemodialysis patients with AoAC score &lt;2 without AVC, followed by those with AoAC score &lt;2 with AVC, and then those with AoAC score ≥2 (log-rank test; all p &lt; 0.01). The grade of AoAC is a significant risk factor for MACE, cardiovascular mortality, and overall mortality after adjusting for age and gender Relative to AoAC score &lt;2 without AVC, adult chronic hemodialysis patients with AoAC score ≥2 remained an independently significantly risk factor of MACE (adjusted hazard ratio, 2.17; 95% confidence interval 1.11–4.20; p = 0.023) after adjusting for age, sex, and all significant variables in baseline characteristics.ConclusionAoAC grade was positively correlated with a higher risk of MACE and cardiovascular and overall mortality. Furthermore, the presence of AVC modified the adverse cardiovascular risk associated with AoAC in patients on MHD.
Incidence, management, and prognosis of post-ischaemic ventricular septal defect: Insights from a 12-year tertiary centre experience
Authors: Treille de Grandsaigne Henri , Bouisset Frédéric , Porterie Jean , Biendel Caroline , Marcheix Bertrand , Lairez Olivier , Labaste François , Elbaz Meyer , Galinier Michel , Delmas Clément 
Published: December 2022

BackgroundAmong mechanical complications of acute myocardial infarction, ventricular septal defect (VSD) is uncommon but still serious. The evolution of emergency coronary revascularisation paradoxically decreased our knowledge of this disease, making it even rarer.AimTo describe ischaemic VSD incidence, management, and associated in-hospital and 1-year outcomes over a 12-years period.MethodsA retrospective single-centre register of patients managed for ischaemic VSD between January 2009 and December 2020.ResultsNinety-seven patients were included representing 8 patients/ years and an incidence of 0.44% of ACS managed. The majority of the patients were 73-years-old males (n = 54, 56%) with STEMI presentation (n = 75, 79%) and already presented with Q necrosis on ECG (n = 70, 74%). Forty-nine (51%) patients underwent PCI, 60 (62%) inotrope/vasopressors infusion, and 70 (72%) acute mechanical circulatory support (IABP 62%, ECMO 13%, and Impella® 3%). VSD surgical repair was performed for 44 patients (45%) and 1 patient was transplanted. In-hospital mortality was 71%, and 86% at 1 year, without significant improvement over the decade. Surgery appears to be a protective factor [0.51 (0.28–0.94) p = 0.003], whereas age [1.06 (1.03–1.09), p &lt; 0.001] and lactate [1.16 (1.09–1.23), p &lt; 0.001] were linked to higher 1-year mortality. None of the patients that were managed medically survived 1 year.ConclusionPost-ischaemic VSD is a rare but serious complication still associated with high mortality. Corrective surgery is associated with better survival, however, timing, patient selection, and a place for mechanical circulatory support need to be defined.
Liquid levothyroxine formulations in patients taking drugs interfering with L-T4 absorption
Authors: Gatta Elisa , Bambini Francesca , Buoso Caterina , Gava Maria , Maltese Virginia , Anelli Valentina , Delbarba Andrea , Pirola Ilenia , Cappelli Carlo 
Published: December 2022

PurposeTo describe the current knowledge on thyroid hormonal profile in patients on liquid L-T4 therapy and drugs known to interfere with L-T4 absorption.MethodsA PubMed/MEDLINE, Web of Science, and Scopus research was performed. Case reports, case series, original studies and reviews written in English and published online up to 31 August 2022 were selected and reviewed. The final reference list was defined based on the relevance of each paper to the scope of this review.ResultsThe available data showed that novel levothyroxine formulations circumvent gastric pH impairment due to multiple interfering drugs such as proton pump inhibitors, calcium or iron supplements, sevelamer, aluminum/magnesium hydroxide and sodium alginate.ConclusionNew formulations can be taken simultaneously with drugs interfering with L-T4 absorption, in particular liquid formulations. Softgel capsules need more studies to support these data.
Localized urban canopy model and improved anthropogenic heat parameters in the weather research and forecasting model: Simulation of a warm-sector heavy rainfall event over the pearl river delta urban agglomeration
Authors: Huang Zehao , Yang Yuanjian , Bi Xueyan , Zong Lian , Li Wanju , Huang Ling 
Published: December 2022

Warm-sector heavy rainfall in South China is a frequent type of precipitation in summer in the Pearl River Delta region. The complexity of the mechanisms involved in the triggering of convection, especially the effects of urbanization, has greatly increased the uncertainty of numerical simulations of warm-sector heavy rainfall. In this study, five new surface parameters with five new anthropogenic heat (AH) parameters were constructed and coupled with the urban canopy model (UCM) of the Weather Research and Forecasting model, version 4.1, based on the local climate zone system over the Pearl River Delta Urban Agglomeration (PRDUA). Taking a typical warm-sector heavy rainfall process that occurred in the PRDUA on 20 April 2019 as an example, five groups of experiments involving different schemes were compared and analyzed, revealing that the precipitation simulated using the localized UCM with the new AH parameters was the best (closest to observations). The localized UCM successfully simulated the increase in 2 m temperature and sensible heat flux and the resultant thermal forcing in urban areas, which promoted the convergence of low-level southerly winds with water vapor and the lifting of the lower-layer warm and humid water vapor to the upper layers in the urban center, leading to a significant increase of precipitation. The improved AH parameters enhanced the anthropogenic heat and its vertical conduction in urban areas, but contributed only marginally to the convergence of 10 m winds. Compared with observations from wind profile radar, it was found that the localized UCM enhanced the accuracy of the simulated horizontal wind field convergence at upper and lower levels, while the improved AH parameters enhanced the accuracy of the simulated low-level jet intensity and vertical movement, which are important drivers for the spatial variation in warm-sector heavy rainfall over the PRDUA. The current findings will be helpful for improving the model skill in simulating warm-sector heavy rainfall over high-density urban areas, as well as enhancing understanding of the impact mechanism of urbanization on the occurrence and development of warm-sector heavy rainfall.
Increasing objectivity associated with anadromous fish redd identification using a discriminant function analysis
Authors: Sellheim Kirsten , Sweeney Jamie , Merz Joseph 
Published: December 2022

Many fish species reproduce by creating nests (redds) in alluvial stream gravels, which can be used to track population trends. However, temporal and spatial overlap across multiple redd-building species can hinder redd species classification. This is further complicated when the corresponding adult is not present. Spawning surveys on the Lower American River (LAR) have been conducted since 2003 to document fall-run Chinook Salmon and California Central Valley (CCV) steelhead spawning. Other fish species on the LAR have overlapping reproduction timing, including Pacific Lamprey. Prior to 2016, a redd observed during field surveys that was not associated with a fish observation was assigned species identity based on seasonal timing and professional judgement. However, this method has potential to misidentify the species that built the redd due to overlap in spawning season and similarity in redd dimensions among LAR fish species. To decrease subjectivity associated with unoccupied redd identification, we used occupied redd data to build a discriminant function analysis (DFA), which predicts redd species identity based on field-measured parameters that vary across species including time of year, redd dimensions, and ambient conditions. We compared model accuracy across 6 years in which additional “fish on” observations were added annually to the discriminant function to test whether adding observational data improved model accuracy. We also applied the discriminant function to historical redd data in which species identification was made based on professional judgement to compare the two approaches. DFA accuracy improved with additional years of data, and in the iteration that included the most observational data it was highly accurate in identifying fall-run Chinook Salmon and CCV steelhead (96% and 97%, respectively). Accuracies for Pacific Lamprey were slightly lower (91%) than salmonids due to the relatively low number of “fish-on” redd observations for Pacific Lamprey. Comparisons between the DFA and historical identification based on professional opinion were generally similar, but with up to 19.6% disagreement in some years. Our study demonstrates that physical and temporal metrics can support more accurate species identification, and field data can be used to support more robust population estimates and inform future habitat restoration decisions.
A Wnt-related gene expression signature to improve the prediction of prognosis and tumor microenvironment in gastric cancer
Authors: Kong Shuai , Li Zhi , Wang Yuanyuan , Zhang Zheming , Jia Xianghao , Gao Xinxin , Cong Bicong , Zhang Fangxu , Zhang Jing , Zheng Chunning 
Published: December 2022

Background: Most gastric cancer (GC) patients were diagnosed in the advanced stages without obvious symptoms, which resulted in the increased risk of death. Although the combination therapies have showed survival benefit of patients, there is still urgent need to explore the underlying mechanisms of GC development and potential novel targets for clinical applications. Numerous studies have reported the upregulation of Wnt signaling pathway in human GC, which play important role during GC development and progression. However, the current understanding of Wnt signaling pathway is still limited due to its complexity and contradictory effect on different stages of GC tumor microenvironment.Method: We used The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) dataset to screen Wnt signaling pathway-associated genes by ssGSEA and correlation analysis. Three molecular subtypes were constructed based on a consistent clustering analysis. The key Wnt-related genes were screened through univariate cox analysis, lasso, and stepwise regression. In addition, the Gene Set Enrichment Analysis (GSEA) were performed to explore potential molecular pathways regulated by the Wnt-related gene signatures. ESTIMATE was utilized for evaluating the immune cell populations in GC tumor microenvironment.Results: Three molecular subtypes associated to Wnt were identified, and 7 key Wnt-related genes were screened to establish a predictive RiskScore model. These three molecular subtypes showed significant prognostic differences and distinct functional signaling pathways. We also found the downregulated immune checkpoint expression in the clust1 with good prognosis. The RiskScore model was successfully validated in GSE26942 dataset. Nomogram based on RiskScore and Gender had better prognostic predictive ability.Conclusion: In summary, our study showed that the Wnt-related genes could be used to predict prognosis of GC patients. The risk model we established showed high accuracy and survival prediction capability.
BAFF blockade attenuates acute graft-versus-host disease directly via the dual regulation of T- and B-cell homeostasis
Authors: Jeon Youngwoo , Lim Jung-Yeon , Im Keon-Il , Kim Nayoun , Cho Seok-Goo 
Published: December 2022

IntroductionB-cell-activating factor (BAFF) is associated with donor-specific antibodies and chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the effects of BAFF on T-cell physiological function have not been fully elucidated in acute GVHD.MethodsWe examined the effects of belimumab, a monoclonal antibody targeting BAFF, for the treatment of acute GVHD. We examined the effects of T cells and B cells separately when inducing GVHD in mouse model.ResultsTherapeutic functional manipulation of endogenous BAFF can improve acute GVHD during the early post-transplant period. In this study, BAFF was shown to increase the proportions of CD4+IL-17+, CD4+IL-6+ Th17, and CD4+IFN-γ+ Th1 cells and to reduce the proportion of regulatory T (Treg) cells. Furthermore, the belimumab therapy group showed increased B220+IgD+IgM+ mature B cells but decreased B220+IgD−IgM− memory B cells, B220+Fas+GL-7+ germinal center formation, and B220+IgD−CD138+ plasma cells. These results indicate that BAFF can alleviate acute GVHD by simultaneously regulating T and B cells. Interestingly, the BAFF level was higher in patients with acute GVHD after HSCT compared with patients receiving chemotherapy.ConclusionThis study suggests that BAFF blockade might modulate CD4 +T-cell-induced acute GVHD early after allo-HSCT and the possibility of simultaneously controlling chronic GVHD, which may appear later after allo-HSCT.
Lumboperitoneal shunt surgery via continuous two-stage procedure: Technique notes and outcomes
Authors: Li Zhao , Wang Hao , Zhang Han , Yang Jiqi , Yang Xiaofeng , Wen Liang 
Published: December 2022

BackgroundLumboperitoneal shunt (LPS) is an effective procedure for managing communicating hydrocephalus. LPS is performed as a one-stage procedure with the patient placed in the lateral position or as a two-stage procedure in which the patient's position is changed. Both methods can be bothersome to neurosurgeons. We designed a continuous two-stage LPS procedure in which the operative sites did not need to be sterilized again, and the surgical drapes did not have to be changed after changing the patient's position. In this study, we analyzed this procedure in terms of the technical features and outcomes.MethodsAll patients from our institute who underwent LPS using the continuous two-stage procedure from October 2019 to August 2021 were reviewed retrospectively. The patient's demographic information, clinical features, operative data, and outcomes were analyzed.ResultsA total of 46 consecutive patients who underwent LPS using the continuous two-stage procedure were enrolled. The mean operative duration was 70.6 ± 12.7 min. The 180-day revision rate for these patients was 2.2% (1/46). Moreover, 76.1% of the patients (35/46) experienced clinical improvement after LPS during the 180-day follow-up, and 70.0% of the patients (32/46) experienced an improvement in neuroimaging.ConclusionWe described a continuous two-stage LPS procedure. This method simplified the two-stage LPS procedure and maintained a low malfunction rate and shunt infection rate in our series.
Single-fraction SRS and multiple-fraction SRT for brain metastases from colorectal cancer
Authors: Li Yong , Wu Junlan , Liu Fenghua , Shao Xianjun , Liang Xiaohua , Zhang Feifei , Meng Yan , Shen Meihua , Pan Mianshun 
Published: December 2022

ObjectiveBrain metastasis from colorectal cancer (CRC) is rare. Although stereotactic radiotherapy (SRT) and stereotactic radiosurgery (SRS) are effective treatments for brain metastasis, reports on brain metastasis of CRC are limited. This study compared the efficacy of SRT and SRS for the treatment of brain metastases from CRC and analysed the related factors to reveal the specificity CRC-derived brain metastasis.MethodsA retrospective analysis of 116 patients with brain metastases from colorectal cancer was performed and included 56 patients in the SRT group and 60 patients in the SRS group. The clinical characteristics of the two groups were analysed, and the local tumour control rate, overall survival time and radiation-induced brain injury were compared between the two groups.ResultsThe objective response rates of the SRT and SRS groups were 76.8% and 66.7%, respectively, while the local control rates at 6 months were 87.5% and 81.6%, respectively, and no significant differences were observed between the groups (P=0.295). The median overall survival time was 10.3 months for all patients and was 10.9 months in the SRT group and 9.8 months in the SRS group, with no significant difference between the groups (P=0.123). A multivariate analysis showed that the main factors of poor prognosis were low GPA score (P=0.002), KRAS mutation (P=0.035), extracranial metastasis (P=0.005) and no bevacizumab treatment (P=0.001). No significant difference was observed in the incidence of acute and late radiation-induced injury between the two groups.ConclusionBoth SRT and SRS are effective methods for the treatment of CRC-derived brain metastases. The simultaneous use of bevacizumab may be one of the most important factors that affects the survival of these patients.