bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health utilities in Chinese patients with coronary heart disease and impaired glucose tolerance (ACE): A longitudinal analysis of a randomized, double‐blind, placebo‐controlled trial
Authors: Leal José , Becker Frauke , Lim Lee‐Ling , Holman Rury R. , Gray Alastair M. 
Published: July 2022

AbstractBackgroundWe estimate health‐related quality of life and the impact of four cardiovascular events (myocardial infarction [MI], stroke, congestive heart failure, angina) and gastrointestinal events in 6522 Chinese patients with coronary heart disease (CHD) and impaired glucose tolerance (IGT) participating in the Acarbose Cardiovascular Evaluation (ACE) trial.MethodsHealth‐related quality of life was captured using the EuroQol‐5 Dimension‐3 Level (EQ‐5D‐3L), with data collected at baseline and throughout the trial. Multilevel mixed‐effects linear regression with random effects estimated health‐related quality of life over time, capturing variation between hospital sites and individuals, and a fixed‐effects linear model estimated the impact of cardiovascular and gastrointestinal events.ResultsPatients were followed for a median of 5 years (interquartile range 3.4‐6.0). The average baseline EQ‐5D score of 0.930 (SD 0.104) remained relatively unchanged over the trial period with no evidence of statistically significant differences in EQ‐5D score between randomized treatment groups. The largest decrement in the year of an event was estimated for stroke (−0.107, P < .001), followed by heart failure (−0.039, P = .022), MI (−0.021, P = .047), angina (−0.012, P = .047), and gastrointestinal events (−0.005, P = .430). MI and stroke reduced health‐related quality of life beyond the year in which the event occurred (−0.031, P = .006, and −0.067, P < .001, respectively).ConclusionsAcarbose treatment had no impact on health‐related quality of life in ACE trial participants with CHD and IGT. Events such as MI, stroke, heart failure, and angina reduce health‐related quality of life around the time they occurred, but only MI and stroke impacted on longer‐term health‐related quality of life.
Petrogenesis of the Carboniferous Intrusive Rock in the Xiaobaishitou District of East Tianshan, Northwest China: Magma Evolution and Tectonic Significance
Authors: LI Ning , ZHANG Zhixin , YANG Fuquan , LIU Dongna 
Published: July 2022

AbstractThe Xiaobaishitou gabbro‐diorite pluton comprises a medium‐grained gabbro‐diorite suite and a fine‐grained diorite suite, which intrude the Kawabulag Group in the East Tianshan Orogen of the Central Asian Orogenic Belt (CAOB). A combination of mineral chemistry, zircon U‐Pb age, whole‐rock geochemistry, Sr‐Nd isotopes, and in situ zircon Hf isotopes for newly found gabbro‐diorite from the Xiaobaishitou district in the Central Tianshan Terrane (CTT) is presented to investigate the petrogenesis and tectonic or even crustal evolution of the East Tianshan Orogen. Laser ablation inductively coupled plasma mass spectrometry (LA‐ICP‐MS) zircon U‐Pb analyses indicate that the gabbro‐diorite was formed at 324.7 ± 2.4 Ma. The isolated clinopyroxene formed under higher P‐T‐ƒO2 melt conditions (10.7–14.6 kbar; 1199–1269°C; high ƒO2) than those for the hornblende, plagioclase, and zircon (557–687°C; moderate ƒO2) in the gabbro‐diorite, which reveals a multilevel, magmatic storage system. The gabbro‐diorite is characterized by fractioned REE patterns, enriched LILEs (e.g., Ba and Pb), negative anomalies of HFSEs (e.g., Nb and Ta), and low La/Yb and Sr/Y ratios, which are typically indicative of crustal contamination and accounted for by subduction‐related fluids. The rock also characterized by typical features of high compatible elements (MgO = 3.14–11.65 wt%, Cr = 1–157 ppm, Ni = 6–830 ppm), high Mg# (47 –74), positive ɛHf(t) values (+5.1 to +10.3) and ɛNd(t) values (+2.3 to +4.4). These features suggest that the Xiaobaishitou gabbro‐diorite was most likely derived from metasomatic mantle and contaminated minor crustal components. Taking into account the spatial and temporal distribution of the Carboniferous magmatic rocks in the CTT, we suggest the formation of the Xiaobaishitou gabbro‐diorite was attributed to southward subduction of the Kangguer Ocean.
Farm‐related injury deaths in Australia (2001–20)
Authors: Lower Tony , Peachey Kerri‐Lynn , Rolfe Margaret 
Published: July 2022

AbstractObjectiveTo describe the agents, pattern and trends of unintentional farm fatalities in Australia (2001–2020).MethodsReview of study of National Coronial Information System data.DesignDescriptive.SettingAustralia (2001–2020).ParticipantsAll cases involving fatal work and non‐work injury events on a farm.Main outcome measuresPatterns and agents of injury events, with trends for all‐cause deaths based on rates per 10 000 farms and work‐related incidents (per 100 000 workers and 1 000 000 h worked).ResultsThere were 1584 unintentional farm fatalities (annual mean 79). Two‐thirds of cases were work‐related (68%). Major agents of injury were farm vehicles (39%) and machinery (26%). Persons aged over 55 years were involved in 58% of all work‐related incidents and were significantly more likely to die than younger cohorts when assessed against hours worked. Death rates involving all on‐farm fatal incidents (both work and non‐work) per 10 000 farms (p = 0.015) and work‐related rates per 100 000 workers (p = 0.015) reduced over the period, with both demonstrating a fluctuating rate. There was no change in the work‐related rates when assessed against hours worked (p = 0.276).ConclusionOver the period, the annualised number of deaths fell by approximately 24% (98–75), with agents of injury remaining similar. General trends suggest a reduction in the overall death rates for work and non‐work incidents. However, trends were less apparent when the reduction of farms (~19%), workers (~7%) and hours worked (no change), were accounted for. Targeted approaches are required to stimulate improvements in these preventable incidents.
Value of computed tomography scores in complicated acute diverticulitis
Authors: Mitreski Goran , McGill Jeannette , Nikolovski Zoran , Jamel Wael , Al‐Kaisey Yasir , Kam Ning Mao , Con Danny , Ardalan Zaid , Kutaiba Numan 
Published: July 2022

AbstractBackgroundDiverticular disease remains one of the most common conditions in the western world. Up to 25% of patients with diverticular disease require hospitalization, 15–30% of those of which require surgical intervention. CT scoring systems have been proposed as means to drive assessment and stratify patients necessitating hospital intervention. To assess and correlate CT scoring systems with clinical and surgical outcomes.MethodsRetrospective cohort analysis at a single institution. Single institutional assessment with patients presenting to emergency with a CT diagnosed episode of acute diverticulitis. One hundred and eighty‐nine patients were included in the study, 61% of which were male. Patient demographics, comorbidities, medications, biochemistry and inflammatory markers, type of complication following acute diverticulitis, operative/procedural intervention, hospital outcome and mortality were measured. CT scoring systems assessed included modified Hinchey, modified Neff, World Society of Emergency Surgery (WSES) and modified Siewert scoring systems.ResultsMajority of patients had left‐sided diverticulitis (91%) with localized air (88%) and pericolic abscess (49%) the most common radiological findings. 28% of patients required radiological and/or surgical management with 12% requiring intensive care unit (ICU) admission. There was a general trend for surgical/radiological intervention as the scores increased in severity. The four scoring systems were found to be statistically significant predictors of any intervention and of ICU admission with minimal statistical differences across the different scoring systems.ConclusionRadiological CT scores for complicated diverticulitis are at best, moderate predictors of clinical and surgical outcomes and may serve to guide management with minimal statistical differences across different scores.
The Logistics of Waste: Engineering, Capital Accumulation, and the Growth of Mexico City
Authors: Chahim Dean 
Published: July 2022

AbstractHow is capital accumulation sustained in the Anthropocene, even as it threatens to overwhelm everyone—capitalists included—in ever‐growing quantities of waste? This paper examines this question at the metropolitan scale, focusing on the growth of Greater Mexico City. In a bid to spur capital accumulation, governments across the megacity increasingly push for new urban developments that encroach on the already‐strained drainage system, limiting its capacity to prevent floods. To protect these developments, state engineers now regularly divert wastewater through the homes and streets of marginalised areas of the metropolis. Even as these diversions turn marginal neighbourhoods into ephemeral waste conduits, the transience of wastewaters and the complexity of engineers’ operations limit the possibilities for collective resistance. This calculative management of the flows of waste—here termed the logistics of waste—is a critical yet understudied way engineering sustains the accumulation of capital and limits popular resistance to elite‐led projects of endless growth.
The association between vaginal microbiota disorders and early missed abortion: A prospective study
Authors: Sun Dan , Zhao Xingping , Pan Qiong , Li Fang , Gao Bingsi , Zhang Aiqian , Huang Huan , Xu Dabao , Cheng Chunxia 
Published: July 2022

AbstractIntroductionThe objective of this study was to explore the association between disordered vaginal microbiota and missed abortion to ascertain potential causes of missed abortion related to vaginal microbiology.Material and methodsThis study was a prospective cohort study with a comparison group (reference group). Vaginal secretions from the posterior fornix of women in the early stages of pregnancy were collected in the Xiangya Third Hospital of Central South University in Changsha, Hunan, China, from November 2018 to November 2019. A total of 54 cases of missed abortion (case group) and 50 cases of normal pregnancy requiring induced abortion (reference group) were analyzed. Bacterial DNA was extracted, hybridized with gene‐specific primers, and then detected using a bacterial chip. The composition and relative abundance of vaginal microbiota in the two groups were compared using α‐diversity analysis, β‐diversity analysis, and the linear discriminant analysis effect size method.ResultsThe α‐diversity analysis showed that the Simpson index of the case group was lower than that of the reference group, whereas the Shannon index in the case group was higher. The relative abundance of Firmicutes in the case group (42.52%) was lower than in the reference group (51.03%, p < 0.05), as was the relative abundance of Lactobacillus (case group 16.51%, reference group 23.00%; p < 0.05). Interestingly, levels of Mycoplasma genitalium and Ureaplasma were lower in the case group (p < 0.05). The relative abundance of Lactobacillus crispatus, Lactobacillus jensenii, and Lactobacillus gasseri was also significantly lower in the case group than in the reference group (p < 0.05). The pathways enriched in the case group were predominantly related to metabolism, whereas the genetics‐related pathways were predominantly enriched in the reference group.ConclusionsBacteria are more diverse and unevenly distributed in patients with missed abortion. Decreases in the proportion of vaginal Lactobacillus and changes in Lactobacillus species in these patients may increase the chance of genital tract pathogenic bacterial infection. To our knowledge, our study was the first to observe that a decrease of Firmicutes levels in the vaginal microbiota might impair energy metabolism and have an association with missed abortion.
Zuragen™ antiseptic catheter lock: A bridge too far?
Authors: Ash Stephen R. 
Published: July 2022

AbstractWhen sodium citrate is used as an anticoagulant catheter lock the best concentration is 7%, since this provides a density approximately the same as blood. Our laboratory found that the addition of methylene blue and parabens greatly augmented antibacterial properties. Ash Access sponsored a randomized clinical trial in 400 dialysis patients with tunneled CVC, and this showed a significant decrease in incidence of catheter‐related bloodstream infection (CRBSI) defined by stringent criteria. The FDA decided that the study missed its primary endpoint, and that the product was mis‐classified, so they did not give approval to market. The licensee decided not to appeal to the decision to the physician panel and ended support of the project. Rights to market the catheter lock eventually returned to Ash Access.
Immigrants and exports: Firm‐level evidence from Canada
Authors: Cardoso Miguel , Ramanarayanan Ananth 
Published: July 2022

AbstractWe examine how immigrant employment enhances trade at the firm level using unique administrative matched employer–employee data from Canada. We augment a standard model of firms' export market entry and sales decisions with trade costs that depend on destination‐specific immigrant employment at the firm level. We estimate simple structural equations derived from the model that relate destination‐specific exporting decisions to immigrant employment. We develop a method to deal with the potential endogeneity of immigrant employment that exploits the optimality conditions associated with the firm's employment decision. We find positive and statistically significant effects of firm‐level immigrant employment on exporting. These effects vary with product type and immigrant employee characteristics in ways consistent with the idea that immigrant employees alleviate information barriers to trade.
Photodistributed eruptive telangiectasias: an uncommon adverse drug reaction. A retrospective case series
Authors: Vaccaro Mario , Di Bartolomeo Luca , Borgia Francesco , Longo Caterina , Vaccaro Federico , Gangemi Sebastiano , Lentini Maria , Caradonna Emanuela 
Published: July 2022

Abstract
Drug-induced photodistributed telangiectasia (PT) is a cutaneous adverse effect (AE) resulting from the interaction of ultraviolet radiation with pharmacotherapy. Reports of PT in the literature are scarce. We report 25 cases of drug-induced PT highlighting the potential relationship between the onset of skin lesions, drug intake and photo exposure. We alert practitioners that PT is a possible dermatological phototoxic AE of many drugs.
Desarrollo de una Réplica Táctil Para Experiencias Inclusivas de Artefactos Religiosos
Authors: Sánchez Allegue Paloma , Melendreras Ruiz Rafael , Marín Torres María Teresa 
Published: July 2022

ResumenEl objetivo principal de este artículo es introducir una primera experiencia inclusiva en un museo convencional que hasta ahora solo exhibe esculturas religiosas y su evaluación por personas ciegas y discapacitados visuales. Por este motivo, se decidió desarrollar una experiencia multisensorial dirigida a personas ciegas y discapacitados visuales, aprovechando el potencial de las nuevas tecnologías de escaneo e impresión 3D. La experiencia se centra en una réplica táctil del busto del Cristo de la Sangre, una obra maestra del barroco muy venerada en Murcia. Se muestra el proceso completo del desarrollo de la réplica, forma de diseño y fabricación, combinando tecnología y tradición. Además del sentido del tacto, la experiencia incorpora descripciones de audio detalladas y olores, para proporcionar información adicional valiosa. Además, las tecnologías radio móviles, como las balizas, se utilizan con fines de orientación. Las personas ciegas y discapacitados visuales juegan un papel activo en este proyecto, tanto en el diseño como en la validación de las experiencias.
Deltagelse og æstetiske oplevelser på kunstmuseet? En Fænomenologisk Analyse
Authors: Høffding Simon , Rung Mette , Roald Tone , Høffding Ditte 
Published: July 2022

ResuméPå museer står deltagelse i dag helt centralt. Brugerne inviteres til at være aktive, indgå i aktiviteter, tale sammen og skabe sammen. Selvom vi hilser denne deltagelsesagenda velkommen som et initiativ, der demokratiserer kunstmuseerne og gør dem relevante for flere mennesker, så argumenterer vi i denne artikel for, at deltagelse også påvirker kunstoplevelsen på en måde, der risikerer at overse en væsentligt dimension ved at opleve kunst. Baseret på kvalitative og fænomenologisk inspirerede interviews med museumsbesøgende præsenterer vi en skitse af denne form for æstetisk oplevelse. Vi diskuterer hvordan der bør tages hensyn til disse oplevelser, både i kurateringspraksis, formidlingen og i diskussionen af formålet med kunstmuseet i dag.
The Real‐WorldObservational Prospective Study of Health Outcomes with Dulaglutide and Liraglutide in Patients with Type 2 Diabetes (TROPHIES): Patient disposition, clinical characteristics and treatment persistence at 12 months
Authors: Guerci Bruno , Giorgino Francesco , Sapin Hélène , Boye Kristina , Lebrec Jérémie , Federici Marco Orsini , Heitmann Elke , Dib Anne , Füchtenbusch Martin , García‐Pérez Luis‐Emilio 
Published: July 2022

AbstractAimsThe primary objective of the TROPHIES observational study is to estimate the duration of treatment on dulaglutide or liraglutide without a significant treatment change by 24 months in patients with type 2 diabetes (T2D) initiating their first injectable treatment with these glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs). This manuscript presents 12‐month interim data.Materials and MethodsTROPHIES is a prospective, non‐comparative, observational study of patients with T2D in Europe, naïve to injectable antihyperglycaemic treatments and initiating dulaglutide or liraglutide. Data on clinical characteristics, GLP‐1 RA persistence and treatment patterns of glucose‐lowering medication were collected at initiation of first injectable therapy and by 12 months.ResultsBy 12 months, 1014 dulaglutide and 991 liraglutide patients were eligible across France, Germany and Italy. Both cohorts presented a high probability [95% confidence interval (CI)] of GLP‐1 RA persistence [dulaglutide, 0.88 (0.86 to 0.90); liraglutide, 0.83 (0.80 to 0.85)] and reduction in mean glycated haemoglobin percentage (95% CI) from baseline [dulaglutide, −1.18 (−1.27 to −1.08); liraglutide, −1.15 (−1.26 to −1.05)] with 48.2% of dulaglutide and 41.2% of liraglutide patients reaching their individualized glycated haemoglobin percentage target set by the physician at baseline. Mean weight (95% CI) change from baseline was −3.2 kg (−3.6 to −2.8) for dulaglutide and −3.4 kg (−3.9 to −3.0) for liraglutide. Slight changes in concomitant medications were observed compared with baseline.ConclusionsIn the real‐world setting, dulaglutide and liraglutide cohorts achieved good persistence with similarly improved glycaemic control that was accompanied by weight loss at 12 months, consistent with previous clinical trial results.
Characteristics of vineyard soils derived from Plio‐Quaternary landforms (raña or rañizo) in southern Europe
Authors: Jiménez‐Ballesta Raimundo , Bravo Sandra , García‐Pradas Jesús , Pérez‐de‐los‐Reyes Caridad , Amorós Jose A. , García‐Navarro Francisco J. 
Published: July 2022

AbstractSoil is an essential component in viticulture. The study reported here concerns the assessment of the morphology chemical and physicochemical features of typical, well‐developed and representative evolved Mediterranean soils near Anchuras (Spain, southern Europe), a site with soils that developed on old landforms (Plio‐Quaternary) called ‘raña’ and/or ‘rañizo’. The soils under study were described and sampled by conducting soil surveys. Selected soil properties, such as texture, bulk density, pH, electrical conductivity (EC), cation exchange capacity (CEC) and contents of organic matter, nutrients, etc., were analysed using standard procedures. The results showed that these landscape surfaces were, linked with specific soil properties such as low pH (from 4.4 to 5.3) and EC (from 0.15 to 0.02 dSm−1), clay contents (20.1%–48.8%), high CEC (26–39 cmol/kg), and low base saturation values (from 11.2% to 17.2%), and have an adequate and singular pedological potential in relation to the ‘terroir’ or ‘terron’ concepts that meet suitability criteria. Furthermore, the information provided by this study, fundamentally through the weathering indices, supports the role of soil‐forming factors and their influence on soil properties. In addition, as these landforms and underlying materials have abundant and extensive rock fragments, the role of these soils in the context of vineyard growth and development has been investigated.HighlightsThere are unknown conceptual zones that support production of wineThis study highlights the importance and uniqueness of vineyard soils linked to old plioquaternary surfaces.Pedogeomorphologic vineyard constraints can serve as a basis for implementing a PDOThe association soils‐old surfaces can contribute to the identity and reputation of a viticultural zone
Nusinersen in adult patients with 5q spinal muscular atrophy: A multicenter observational cohorts' study
Authors: Vázquez‐Costa Juan F. , Povedano Mónica , Nascimiento‐Osorio Andrés E. , Moreno Escribano Antonio , Kapetanovic Garcia Solange , Dominguez Raul , Exposito Jessica M. , González Laura , Marco Carla , Medina Castillo Julita , Muelas Nuria , Natera de Benito Daniel , Ñungo Garzón Nancy Carolina , Pitarch Castellano Inmaculada , Sevilla Teresa , Hervás David 
Published: July 2022

AbstractBackground and purposeThe aim was to assess the safety and efficacy of nusinersen in adult 5q spinal muscular atrophy (SMA) patients.MethodsPatients older than 15 years and followed for at least 6 months with one motor scale (Hammersmith Functional Motor Scale Expanded, HFMSE; Revised Upper Limb Module, RULM) in five referral centers were included. The clinical and patients' global impression of change (CGI‐C and PGI‐C) were recorded in treated patients at the last visit. Functional scales (Egen Klassification, EK2; Revised Amyotrophic Lateral Sclerosis Functional Rating Scale, ALSFRS‐R) and the percentage predicted forced vital capacity were collected when available.ResultsSeventy‐nine SMA patients (39 treated with nusinersen) were included. Compared with untreated patients, treated patients showed a significant improvement of 2 points (±0.46) in RULM (p < 0.001) after 6 months. After a mean follow‐up of 16 months, nusinersen treatment was associated with a significant improvement in HFMSE (odds ratio [OR] 1.15, p = 0.006), the 6‐min walk test (OR = 1.07, p < 0.001) and the EK2 (OR = 0.81, p = 0.001). Compared with untreated patients, more treated patients experienced clinically meaningful improvements in all scales, but these differences were statistically significant only for RULM (p = 0.033), ALSFRS‐R (p = 0.005) and EK2 (p < 0.001). According to the CGI‐C and PGI‐C, 64.1% and 61.5% of treated patients improved with treatment. Being a non‐sitter was associated with less response to treatment, whilst a longer time of treatment was associated with better response. Most treated patients (77%) presented at least one adverse event, mostly mild.ConclusionsNusinersen treatment is associated with some improvements in adult SMA patients. Most severely affected patients with complex spines are probably those with the most unfavorable risk–benefit ratio.