bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of the Combination of Teriparatide and Denosumab in the Treatment of Postmenopausal Osteoporosis: A Meta-Analysis
Authors: Sun Yang , Li Yue , Li Jiangbi , Xie Xiaoping , Gu Feng , Sui Zhenjiang , Zhang Ke , Yu Tiecheng 
Published: May 2022

Aim: Evidence on the efficacy of combination treatment of teriparatide and denosumab for osteoporosis remains controversial. We aim to compare the efficacy between the combination treatment and monotherapy among patients with postmenopausal osteoporosis.Methods and results: We systematically searched PubMed, EMBASE, the Cochrane Library, and Web of Science up to 26 January 2022, for relevant studies. This meta-analysis reviewed all randomized controlled trials (RCTs) that reported on the combination treatment of teriparatide and denosumab in patients with postmenopausal osteoporosis. The articles were examined individually by two reviewers, and the relevant data was extracted. We combined weighted mean difference (WMD) for bone mineral density (BMD) using random- or fixed- effect models and conducted subgroup analyses. Sensitivity analyses were performed, and possible publication bias was also assessed. Overall, combination treatment enhanced the mean percent change of bone mineral density in lumbar spine than monotherapy (WMD = 2.91, 95%CI: 1.983.83; p = 0.00). And, combination treatment has been beneficial for enhancing the mean percent change of BMD in hip (WMD = 3.19, 95%CI: 2.25∼4.13; p = 0.00). There was no significant difference between combination treatment and monotherapy in terms of the adverse events (RR = 0.81, 95%CI: 0.45∼1.45; p = 0.472).Conclusion: The meta-analysis indicates that combination treatment led to greater BMD at the lumbar spine and hip in comparison to monotherapy, without an increased incidence of adverse events.Systematic Review Registration: (https://inplasy.com/), identifier (Inplasy Protocol 2734).
Altered Metabolomics in Bipolar Depression With Gastrointestinal Symptoms
Authors: Guo Xiang-Jie , Xiong Yan-Bing , Jia Yuan , Cui Xiao-Hong , Wu Wen-Ze , Tian Jun-Sheng , Yang Hong , Ren Yan 
Published: May 2022

ObjectiveAlthough gastrointestinal (GI) symptoms are very common in patients with bipolar disorder (BD), Few studies have researched the pathomechanism behind these symptoms. In the present study, we aim at elucidate the pathomechanism of GI symptoms in BD through metabolomic analysis.MethodBD patients were recruited from Shanxi Bethune Hospital that divided into two groups, each group assessed with the 24-item Hamilton Depression Rating Scale (HAMD-24) according to the presence or absence of GI symptoms. Healthy controls were recruited from the medical examination center of the same hospital. Differential metabolites were identified and further analyzed using Metabo Analyst 3.0 to identify associated metabolic pathways.ResultsThere were significantly higher HAMD-24 scores in the GI symptoms group than that of non-GI symptoms group (p = 0.007). Based on metabolomic analysis results, we found that the common disturbances metabolic pathway of both two patients groups was ketone body metabolism, and the unique disturbances metabolic pathways of BD with GI symptoms were fatty acid biosynthesis and tyrosine metabolism, and these changes were independent of dietary habits.ConclusionBD patients with GI symptoms exhibited disturbances in fatty acid and tyrosine metabolism, perhaps suggesting that the GI symptoms in BD patients are related to disturbances of the gut microbiome. Both groups of patients jointly exhibit disturbances of ketone body metabolism, which may serve as a biomarker for the pathogenesis of BD patients.
Potentials of Low-Budget Microdrones: Processing 3D Point Clouds and Images for Representing Post-Industrial Landmarks in Immersive Virtual Environments
Authors: Weißmann Marco , Edler Dennis , Rienow Andreas 
Published: May 2022

Post-industrial areas in Europe, such as the Rhine-Ruhr Metropolitan region in Germany, include cultural heritage sites fostering local and regional identities with the industrial past. Today, these landmarks are popular places of interest for visitors. In addition to portable camera devices, low-budget ultra-lightweight unmanned aerial vehicles, such as micro quadcopter drones, are on their way to being established as mass photography equipment. This low-cost hardware is not only useful for recreational usage but also supports individualized remote sensing with optical images and facilitates the acquisition of 3D point clouds of the targeted object(s). Both data sets are valuable and accurate geospatial data resources for further processing of textured 3D models. To experience these 3D models in a timely way, these 3D visualizations can directly be imported into game engines. They can be extended with modern interaction techniques and additional (semantic) information. The visualization of the data can be explored in immersive virtual environments, which allows, for instance, urban planners to use low-cost microdrones to 3D map the human impact on the environment and preserve this status in a 3D model that can be analyzed and explored in following steps. A case example of the old wage hall of the Zeche “Bonifacius” (Essen, Germany) with its simple building structure showed that it is possible to generate a detailed and accurate 3D model based on the microdrone data. The point cloud which the 3D model of the old wage hall was based on represented partly better data accuracy than the point clouds derived from airborne laser scanning and offered by public agencies as open data. On average, the distance between the point clouds was 0.7 m, while the average distance between the airborne laser scanning point cloud and the 3D model was −0.02 m. Matching high-quality textures of the building facades brings in a new aspect of 3D data quality which can be adopted when creating immersive virtual environments using the Unity engine. The example of the wage hall makes it clear that the use of low-cost drones and the subsequent data processing can result in valuable sources of point clouds and textured 3D models.
Development of the United States Environmental Protection Agency’s Facilities Status Dashboard for the COVID-19 Pandemic: Approach and Challenges
Authors: Baxter Lisa , Baynes Jeremy , Weaver Anne , Neale Anne , Wade Timothy , Mehaffey Megan , Lobdell Danelle , Widener Kelly , Cascio Wayne 
Published: May 2022

Objectives: Develop a tool for applying various COVID-19 re-opening guidelines to the more than 120 U.S. Environmental Protection Agency (EPA) facilities.Methods: A geographic information system boundary was created for each EPA facility encompassing the county where the EPA facility is located and the counties where employees commuted from. This commuting area is used for display in the Dashboard and to summarize population and COVID-19 health data for analysis.Results: Scientists in EPA’s Office of Research and Development developed the EPA Facility Status Dashboard, an easy-to-use web application that displays data and statistical analyses on COVID-19 cases, testing, hospitalizations, and vaccination rates.Conclusion: The Dashboard was designed to provide readily accessible information for EPA management and staff to view and understand the COVID-19 risk surrounding each facility. It has been modified several times based on user feedback, availability of new data sources, and updated guidance. The views expressed in this article are those of the authors and do not necessarily represent the views or the policies of the U.S. Environmental Protection Agency.
Análisis teórico de la influencia de las Microfinanzas en el crecimiento económico
Authors: Rivera Poma Mauricio , Gallegos Santillán Doris 
Published: May 2022

Este artículo busca desarrollar un recorrido teórico para determinar la influencia que han tenido las microfinanzas y su principal producto, el microcrédito, como motor de impulso para el crecimiento económico de las naciones: para lo cual se utilizaron los métodos histórico lógico, deductivo e inductivo e histórico lógico. En este estudio, se describe las distintas corrientes favorables y opositoras sobre la influencia que tiene el desarrollo financiero y el crecimiento económico, se describen las principales características de las microfinanzas y el microcrédito; también se describen los resultados obtenidos por varias investigaciones acerca de los beneficios que han mostrado las microfinanzas en variables como la pobreza, el ingreso. Finalmente se describen algunas investigaciones que muestran los resultados empíricos de la relación cuantitativa entre crecimiento económico, microfinanzas y microcrédito.
Aging nose () in the practice of an otorhinolaryngologist
Authors: Карпищенко С.А. , Лавренова Г.В. , Гаськова П.И. 
Published: May 2022

Старение населения, увеличение продолжительности активной жизни диктуют необходимость поддерживать уровень здоровья и создавать условия для продления и сохранения трудоспособности. С возрастными изменениями, происходящими в полости носа и околоносовых пазухах, все чаще приходится сталкиваться врачу-оториноларингологу. Актуальным вопросом становится изучение этих возрастных особенностей не только на уровне функции, но и структуры, обеспечивающих поддержание защитных механизмов слизистой оболочки, сохраняющих архитектонику носа. Детальное рассмотрение проблемы может стать ключом для понимания того, что является естественным процессом с течением времени, а что нужно рассматривать как патологию. Нередко эти процессы взаимосвязаны. Например, вследствие старения хрящевой ткани и опущения кончика носа могут запускаться патофизиологические механизмы, создающие препятствие для нормального носового дыхания у пожилых пациентов. Старение носа, сопровождающееся повышенной сухостью, в одних случаях, ринореей, постназальным стеканием - в других, ухудшением обоняния, снижает качество жизни, требуя помощи врача-оториноларинголога. Некоторые термины, применяемые для обозначения возрастных изменений в лор-органах, известны и употребляются с давних времен - presbyacusis (снижение слуха), presbyosmia (снижение обоняния), presbyathacsia (способность сохранять равновесие), другие появились относительно недавно, как, например, presbynasalis - cтареющий нос, и требуют уточнения.
Population aging, increasing in duration of active life dictate to keep the level of health and create conditions for prolongation and preservation of ability to work. An otorhinolaryngologist often has to deal with age-related changes occurring in the nasal cavity and paranasal sinuses. The study of age-related features occurring in the nasal cavity and paranasal sinuses at the level of not only function, but also structures providing maintenance of mucous membrane protective mechanisms, preserving nasal architectonics, becomes a topical issue. Detailed consideration can be the key to understanding what is a natural process over time, and what should be viewed as pathology. These processes are often interrelated. For example, cartilage aging and nasal tip ptosis may trigger pathophysiologic mechanisms that create an obstacle to normal nasal breathing in older patients. Nasal aging accompanied by increasing dryness, rhinorrhea in some cases, postnasal drip in others, decreased sense of smell, reduces the quality of life, which will also need the involvement of an otorhinolaryngologist. In otorhinolaryngology, some of the terms used to describe age-related changes in the ent organs have been known and used since ancient times - presbyacusis (decreased hearing), presbyosmia (decreased sense of smell), presbyathacsia (ability to maintain equilibrium). Others are relatively recent, such as presbynasalis - an aging nose.
Desde los Pirineos y los Apeninos. La convergencia de oleadas migratorias en una ciudad pampeana
Authors: Andreucci Bibiana Mabel , Mare Nicolás 
Published: May 2022

Este artículo busca, a partir del análisis genealógico de dos familias de inmigrantes representantes de oleadas migratorias diferentes que convergieron en Chivilcoy, caracterizarlas según los lugares de origen, el contexto y las redes que configuraron. La finalidad, es abordar la coexistencia de situaciones en las que se tendía a reforzar el vínculo con connacionales y otras en las que primaba la integración entre los distintos grupos de migrantes con la población criolla. La superposición de migrantes recientes con más antiguos y con la población criolla permite observar modos de integración en algunos casos, pero no en todos y de asimilación o diferenciación según las circunstancias.
Para ello, partiremos del estudio de las trayectorias del inmigrante vasco-francés Francisco Duarte y del italiano meridional Pasqual Grisolia, que permiten observar las relaciones sociales en movimiento, al conjugar el tiempo corto del curso de sus vidas con procesos estructurales y con los cambios que se fueron dando en los traspasos generacionales. De este modo, tópicos tradicionales de los estudios migratorios como la endogamia y la participación civil se enriquecen al integrarlos al tiempo familiar y al colectivo.
The Effect of Regional Original Income on the Capital Expenditure of the West Aceh Regency Government
Authors: Samsidar Samsidar , Maulina Rina , Vonna Sari Maulida , Rahmazaniati Linda , Rahmadani Ika 
Published: May 2022

ABSTRAK Penelitian ini bertujuan untuk menguji pengaruh pendapatan asli daerah yang merupakan sumber pendapatan asli Pemerintah Kabupaten Aceh Barat terhadap belanja modal Pemerintah Kabupaten Aceh Barat. Teknik pengumpulan data yang dilakukan pada penelitian ini adalah dengan bentuk observasi (pengamatan), dengan cara studi dokumentasi yaitu mencari data-data sekunder yang diperlukan yang berhubungan dengan permasalahan yang akan dibahas dengan menggunakan data penelitian berupa laporan realisasi APBD selama 5 periode yaitu pada tahun anggaran 2015-2019 yang diperoleh dari Badan Pengelolaan Keuangan Daerah Kabupaten Aceh Barat. Metode analisis data yang digunakan dalam penelitian ini adalah analisis regresi linier sederhana. Berdasarkan hasil uji hipotesis dapat diketahui bahwa H0 diterima dan H1 ditolak yang artinya bahwa variabel pendapatan asli daerah tidak berpengaruh terhadap belanja modal pemerintah pada Kabupaten Aceh Barat. Kemudian dalam pengujian koefisien determinasi (R2) diperoleh nilai koefesien determinasi (R2) sebesar 0,455 atau 45,5% yang artinya besarnya kontribusi yang diberikan oleh variabel pendapatan asli daerah terhadap belanja modal sebesar 45,5%, sedangkan sisanya sebesar 54,5% dijelaskan oleh variabel lain dalam model lain. Kata Kunci: Pendapatan Asli Daerah, Belanja Modal, Pemkab ABSTRAK This study aims to examine the effect of local revenue which is the source of the original revenue of the West Aceh District Government on the capital expenditure of the West Aceh District Government. The data collection technique carried out in this study was in the form of observation, by means of a documentation study, namely looking for the necessary secondary data related to the problems to be discussed using research data in the form of a APBD realization report for 5 periods, namely in the fiscal year. 2015-2019 obtained from the Regional Financial Management Agency of West Aceh Regency. The data analysis method used in this research is simple linear regression analysis. Based on the results of the hypothesis test, it can be seen that H0 is accepted and H1 is rejected, which means that the regional original income variable has no effect on government capital expenditures in West Aceh Regency. Then in testing the coefficient of determination (R2), the value of the coefficient of determination (R2) is 0.455 or 45.5%, which means that the contribution given by the regional original income variable to capital expenditure is 45.5%, while the rest is 54.5% is explained by other variables in other models. Keywords: Regional Original Income, Capital Expenditure, District Government
Pengaruh Kedisiplinan Pegawai Terhadap Efektivitas Pelayanan Publik Pada Kantor Camat Kecamatan Bubon Kabupaten Aceh Barat
Authors: Maulida Ani , Mardhiah Nellis 
Published: May 2022

The study aims to determine the effect of employee discipline on the effectiveness of public services at the District Head Office of Bubon, West Aceh Regency. This research uses a quantitative approach with an causal associative method . The data collection technique in this study used a questionnaire or questionnaire technique with scale measurements using a Likert Scala. The research instrument test used validity and realibility tests. Then the data analysis technique used simple linear regression analysis, product moment correlation, correlation coefficient and hypothesis testing using IBM Statistical Package for Social Science. The result of research conducted on 50 respondents at the Head Office of Bubon District, West Aceh Regency showed that there is a significant influence between employee discipline on the effectiveness of public services shows a positive direction. Based on the summary of the table, it is found that the influence of discipline (X) on the effectiveness of public services (Y) is 0.406 or 40.6% categorized as “quite influential”. Where the value of 40.6% shows the effect of the discipline variable (X) on the effectiveness of public service variables (Y) of 40.6%, while the rest is influenced by other factors.
Kualitas Pelayanan Terhadap Kepuasan Masyarakat Di Kantor Kecamatan Johan Pahlawan
Authors: Reda Devy 
Published: May 2022

Service quality is the most important value in a service agency, service quality is very influential on the satisfaction received by the community. The purpose of the study was to determine the level of community satisfaction with service agencies, to determine the level of satisfaction and level of disappointment of the community, the type of method used was a qualitative method because this method was used to extract information from what was experienced, and witnessed directly
ANALISIS KARAKTER KERJA KERAS TERHADAP MATA PELAJARAN FISIKA DI SMA NEGERI 1 KOTA JAMBI
Authors: Kholilah Kholilah , Pratiwi Maharani Rizky , Wahyuni Sri , Yolviansyah Fauziah , Wicaksono Langgengyoga 
Published: May 2022

Tujuan dari penelitian ini adalah untuk menganalisis karakter kerja keras terhadap mata pelajaran fisika di lingkungan sekolah SMA Negeri 1 Kota Jambi. Metode yang digunakan dalam penelitian ini adalah metode peniltian analisis kuantitatif. Metode ini termasuk metode statistika deskriptif. Metode statistika deskriptif adalah metode bagian statistika mengenai pengumpulan data, penyajian, penentuan nilai-nilai statistika, pembuatan diagram atau gambar mengenai sesuatu hal, disini data yang disajikan dalam bentuk yang lebih mudah dipahami atau dibaca. . Data yang digunakan dalam penelitian ini adalah data primer. Data primer adalah data asli yang dikumpulkan sendiri oleh peneliti untuk menjawab masalah yang sedang di teliti. Subjek dari penelitian adalah siswa SMA Negeri 1 Kota Jambi, kelas XI MIPA 4 berjumlah 20 orang, kelas XI MIPA 5 berjumlah 20 orang dan kelas XI MIPA 6 berjumlah 20 orang. Dimana hasil dari penelitian ini menyatakan bahwa dari semua pernyataan yang telah diberikan SMA Negeri 1 Kota Jambi telah berhasil menerapkan nilai-nilai karakter kerja keras dalam pembelajaran FisikaThe purpose of this study was to analyze the character of hard work on physics subjects in SMA Negeri 1 Jambi City. The method used in this research is quantitative analysis research method. This method is a descriptive statistical method. Descriptive statistical method is a method of the statistics section regarding data collection, presentation, determining statistical values, making diagrams or pictures of something, here the data is presented in a form that is easier to understand or read. . The data used in this study are primary data. Primary data is the original data that the researcher has collected himself to answer the problem being studied. The subjects of the study were students of SMA Negeri 1 Kota Jambi, class XI MIPA 4 totaling 20 people, class XI MIPA 5 totaling 20 people and class XI MIPA 6 totaling 20 people. Where the results of this study state that of all the statements that have been given by SMA Negeri 1 Jambi City, they have succeeded in applying the values of hard work character in learning physics.
KARAKTERISTIK GUA KELELAWAR DI KAWASAN KARST RAMMANG-RAMMANG MAROS TN BANTIMURUNG BULUSARAUNG
Authors: Sambolangi Arise , Arsyad Muhamad , Tiwow Vistarani Arini 
Published: May 2022

Telah dilakukan penelitian tentang karakteristik gua di Kawasan Karst Rammang-Rammang Maros. Karst Rammang-Rammang Maros yang masih alami, memicu kelelawar bersarang di salah satu gua di Kawasan Karst Rammamg-Rammang Maros, warga sekitar menamai gua tersebut sebagai Gua Kelelawar, dikarenakan kelelawar yang hidup di dalam gua. Saat ini, penelitian mengenai karakteristik gua masih jarang dilakukan. Oleh karena itu, dilakukan penelitian untuk mngetahui karakterisik Gua Kelelawar di Kawasan Karst Rammang-Rammang Maros. Tujuan penelitian ini adalah menganalisis karakteristik Gua Kelelawar. Pengambilan data karakteristik Gua Kelelawar dengan ng berupa pengamatan langsung dan mengunakan data sekunder.Dari hasil penelitian didapatkan karakteristik kawasan Wisata Gua meliputi sungai temperatur, intensitas cahaya, kelembaban, flora dan fauna gua serta keberadaan ornamen gua. Beberapa jenis fauna yang ditemukan di dalam gua yakni kelelawar, dan kera. Sedangkan flora yang ditemukan yaitu berupa tumbuhan lumut, keberadaannya menandakan di dalam gua tersebut memiliki intensitas cahaya dan temperatur rendah, serta kelembaban yang tinggi. Selain lumut, ditemukan ada beberapa pohon dan rumput-rumput liar di sekitar gua. Beberapa ornamen gua yang dapat dilihat seperti stalaktit, dan Pilar.
ANALISIS HASIL BELAJAR FISIKA PESERTA DIDIK SMAN 6 BARRU SELAMA PEMBELAJARAN DI MASA PANDEMI COVID-19
Authors: Hamka Rizky Amalia , Nurhayati Nurhayati , Yani Ahmad 
Published: May 2022

Penelitian ini adalah penelitian survei dengan pendekatan deskriptif kuantitatif yang bertujuan untuk mendeskripsikan hasil belajar fisika peserta didik kelas XI MIPA di SMAN 6 Barru tahun ajaran 2020/2021 selama dilaksanakannya pembelajaran daring di era pandemi Covid-19. Variabel dalam penelitian ini adalah hasil belajar. Populasi dan sampel dalam penelitian ini adalah seluruh peserta didik kelas XI MIPA SMAN 6 Barru tahun ajaran 2020/2021 berjumlah 55 peserta didik. Data hasil penelitian diperoleh dengan memberikan tes tertulis berupa pilihan ganda diakhir pembelajaran. Berdasarkan hasil analisis data diperoleh bahwa hasil belajar fisika peserta didik kelas XI MIPA di SMAN 6 Barru tahun ajaran 2020/2021 secara rata-rata adalah 70,36 atau berada pada kategori tinggi.
ANALISIS KUALITAS BUTIR SOAL PADA MATA PELAJARAN FISIKA DI JURUSAN FISIKA FAKULTAS MIPA UNIVERSITAS NEGERI GORONTALO TAHUN AJARAN 2021/2022
Authors: Abdullah Nurfadillah , Jahja Mohammad , Setiawan Dewa Gede Eka 
Published: May 2022

Penelitian ini dilakukan untuk menganalisis kualitas butir soal yang digunakan untuk mengukur kemampuan mahasiswa pada mata pelajaran fisika di jurusan fisika, fakultas MIPA, Universitas Negeri Gorontalo. Peserta pada mata pelajaran ini terdiri dari 22 mahasiswa. Soal yang diberikan berupa soal pilihan ganda berjumlah 10 butir. Model rasch digunakan untuk mendapatkan butir soal yang fit. Analisis ini dilakukan dengan bantuan software Winsteps. Dari output program Winsteps diperoleh hasil 10 butir soal sesuai dengan model Rasch dengan nilai rata-rata Outifit MNSQ untuk person dan item masing-masing 1,26 dan 1,26. Sedangkan niali Outfit ZSTD untuk person dan item masing-masing 0,07 dan 0,14. Sedangkan reliabilitas untuk person dan item masing-masing 0,50 dan 0,84. Kata Kunci : fit, model rasch, winsteps, reliabilitas