bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Model Predicting Mortality of Hospitalized Covid-19 Patients Four Days After Admission: Development, Internal and Temporal-External Validation
Authors: Heber Stefan , Pereyra David , Schrottmaier Waltraud C. , Kammerer Kerstin , Santol Jonas , Rumpf Benedikt , Pawelka Erich , Hanna Markus , Scholz Alexander , Liu Markus , Hell Agnes , Heiplik Klara , Lickefett Benno , Havervall Sebastian , Traugott Marianna T. , Neuböck Matthias J. , Schörgenhofer Christian , Seitz Tamara , Firbas Christa , Karolyi Mario , Weiss Günter , Jilma Bernd , Thålin Charlotte , Bellmann-Weiler Rosa , Salzer Helmut J. F. , Szepannek Gero , Fischer Michael J. M. , Zoufaly Alexander , Gleiss Andreas , Assinger Alice 
Published: January 2022

ObjectiveTo develop and validate a prognostic model for in-hospital mortality after four days based on age, fever at admission and five haematological parameters routinely measured in hospitalized Covid-19 patients during the first four days after admission.MethodsHaematological parameters measured during the first 4 days after admission were subjected to a linear mixed model to obtain patient-specific intercepts and slopes for each parameter. A prediction model was built using logistic regression with variable selection and shrinkage factor estimation supported by bootstrapping. Model development was based on 481 survivors and 97 non-survivors, hospitalized before the occurrence of mutations. Internal validation was done by 10-fold cross-validation. The model was temporally-externally validated in 299 survivors and 42 non-survivors hospitalized when the Alpha variant (B.1.1.7) was prevalent.ResultsThe final model included age, fever on admission as well as the slope or intercept of lactate dehydrogenase, platelet count, C-reactive protein, and creatinine. Tenfold cross validation resulted in a mean area under the receiver operating characteristic curve (AUROC) of 0.92, a mean calibration slope of 1.0023 and a Brier score of 0.076. At temporal-external validation, application of the previously developed model showed an AUROC of 0.88, a calibration slope of 0.95 and a Brier score of 0.073. Regarding the relative importance of the variables, the (apparent) variation in mortality explained by the six variables deduced from the haematological parameters measured during the first four days is higher (explained variation 0.295) than that of age (0.210).ConclusionsThe presented model requires only variables routinely acquired in hospitals, which allows immediate and wide-spread use as a decision support for earlier discharge of low-risk patients to reduce the burden on the health care system.Clinical Trial RegistrationAustrian Coronavirus Adaptive Clinical Trial (ACOVACT); ClinicalTrials.gov, identifier NCT04351724.
Progestin-Primed Ovarian Stimulation Versus Mild Stimulation Protocol in Advanced Age Women With Diminished Ovarian Reserve Undergoing Their First In Vitro Fertilization Cycle: A Retrospective Cohort Study
Authors: Tu Xiaoyu , You Bingbing , Jing Miaomiao , Lin Chenxi , Zhang Runju 
Published: January 2022

ObjectiveTo assess and compare the feasibility of progestin-primed ovarian stimulation (PPOS) protocol with mild stimulation protocol for advanced age women with diminished ovarian reserve (DOR) undergoing their first in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycle.MethodsPatients aged ≥35 years and DOR undergoing their first IVF/ICSI cycle were enrolled in this retrospective cohort study: 139 and 600 patients underwent the PPOS and mild stimulation protocols, respectively. The primary outcomes were cumulative clinical pregnancy rate (CCPR) and cumulative live birth rate (CLBR). The secondary outcomes were the number of oocytes retrieved and top-quality embryos.ResultsThere was nearly no significant difference of baseline characteristics between the two groups. Although a greater amount of total gonadotropin (1906.61 ± 631.04 IU vs. 997.72 ± 705.73 IU, P&lt;0.001) and longer duration of stimulation (9 (10–7) vs. 6 (8–4), P&lt;0.001) were observed in the PPOS group, the number of retrieved oocytes (3 (6–2) vs. 2 (4–1), P&lt;0.001) and top-quality embryos (1 (2–0) vs. 1 (2–0), P=0.038) was greater in the PPOS group than the mild stimulation group. Meanwhile, the incidence of premature luteinizing hormone (LH) surge rate was significantly lower in the PPOS group (0.7% vs.8.3%, P=0.001) than the mild stimulation group. However, there was no significant difference in conservative CCPR, conservative CLBR, optimistic CCPR, and optimistic CLBR between the two groups (all P&gt;0.05). A multivariate logistic regression model showed significant positive effects of the number of retrieved oocytes and number of top-quality embryos on conservative CCPR (OR=1.236, 95%CI: 1.048–1.456, P=0.012, OR=2.313, 95%CI: 1.676–3.194, P&lt;0.001) and conservative CLBR (OR=1.250, 95%CI: 1.036–1.508, P=0.020, OR=2.634, 95%CI: 1.799–3.857, P&lt;0.001) respectively, while significant negative effects of age were identified for conservative CCPR (OR=0.805, 95%CI: 0.739–0.877, P&lt;0.001) and conservative CLBR (OR=0.797, 95%CI: 0.723–0.879, P&lt;0.001).ConclusionThe PPOS protocol is an effective alternative to the mild stimulation protocol for advanced age patients with DOR, as it provides comparable reproductive outcomes and better control of premature LH surge. Further, more oocytes and top-quality embryos were obtained in the PPOS group, which had a positive association with conservative CCPR and CLBR.
Prospective Rates, Longitudinal Associations, and Factors Associated With Comorbid Insomnia Symptoms and Perceived Cognitive Impairment
Authors: Garland Sheila N. , Ivers Hans , Savard Josée 
Published: January 2022

BackgroundInsomnia and cognitive impairment are both common conditions experienced by people diagnosed with cancer. Individually, these conditions have negative impacts on functioning, but the combined burden has yet to be evaluated. The purpose of this research was to estimate rates of comorbid insomnia and perceived cognitive impairments, examine the longitudinal associations between these two conditions, and identify demographic and clinical factors associated with reporting both insomnia and perceived cognitive impairment.MethodsIn this secondary analysis, a heterogeneous sample of 962 patients completed the Insomnia Severity Index (ISI) and the Cognitive Failures Questionnaire (CFQ) at the time of their cancer surgery (baseline; T1) and then again at 2 (T2), 6 (T3), 10 (T4), 14 (T5), and 18 (T6) months. Correlations and partial correlations, controlling for age and education level, were computed at each time point to assess the relationship between ISI and CFQ scores. Cross-lagged correlations assessed associations between ISI and CFQ scores over time. Proportions of patients with comorbid insomnia and cognitive impairments were calculated and logistic regressions investigated changes over time in these proportions. ANOVAs, logistic regressions, ordinal regressions, and multinomial regressions were used to identify risk factors of having comorbid insomnia and cognitive difficulties.ResultsSignificant and bidirectional correlations between ISI and CFQ scores were observed at each time point and over time. The proportion of patients having both clinical levels of insomnia and perceived cognitive difficulties ranged from 18.73 to 25.84% across time points and this proportion was significantly greater at T1 and T2 than T4, T5, and T6. Participants who reported comorbid insomnia and cognitive impairment were more likely to be younger, female, not currently working, currently receiving chemotherapy, with clinical levels depression and anxiety, and using antidepressants or anxiolytics.ConclusionComorbid insomnia and perceived cognitive impairment affects around one in five patients and is more frequent at the beginning of the cancer care trajectory. The relationship between insomnia and cognitive impairment appears to be bidirectional. Insomnia may represent an important patient level vulnerability that when identified and treated can improve perception of cognitive function.
Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study
Authors: Wang Fei , Fei Min , Hu Wen-Zheng , Wang Xiao-Dan , Liu Shuai , Zeng Yan , Zhang Jin-Hong , Lv Yang , Niu Jian-ping , Meng Xin-ling , Cai Pan , Li Yang , Gang Bao-zhi , You Yong , Lv Yan , Ji Yong 
Published: January 2022

BackgroundConstipation and dementia have similar epidemiological characteristics. Changes in intestinal flora and characteristics of the brain-gut axis play roles in the pathogeneses of the two diseases, suggesting that there may be a close connection between the two. Most of the studies on constipation in dementia patients have focused on the population with α-synucleinopathies [Parkinson’s disease dementia (PDD), dementia with Lewy bodies (DLB)]. Few studies have reported the prevalence of constipation in all-cause dementia and mild cognitive impairment (MCI) populations.ObjectiveTo assess the prevalence of constipation in patients with all-cause dementia and MCI subtypes and to explore the association between constipation with dementia and MCI subtypes.MethodsFrom May 2019 to December 2019, we conducted a population-based cross-sectional survey. A total of 11,743 participants aged 65 or older from nine cities in China were surveyed. Participants underwent a series of clinical examinations and neuropsychological measurements. Constipation, dementia, MCI and MCI subtype were diagnosed according to established criteria through standard diagnostic procedures.ResultsThe overall age- and sex-adjusted prevalence of constipation in individuals aged 65 years and older was 14.8% (95% CI, 14.6–15.0). The prevalence rates of constipation were19.2% (95% CI, 17.3–21.0), 19.1% (95% CI, 16.8–21.5), 14.4% (95% CI, 12.8–15.9), and 13.8% (95% CI, 13.0–14.6) in the dementia, non-amnestic (na)-MCI, amnestic (a)-MCI and normal cognition populations, respectively. Multivariate logistic regression analysis showed that higher prevalence of constipation was associated with dementia (p = 0.0.032, OR = 1.18, 95% CI: 1.02–1.38) and na-MCI (p = 0.003, OR = 1.30, 95% CI: 1.09–1.54).ConclusionThe present study found a high prevalence of constipation in elderly individuals in China, and higher in patients with dementia and na-MCI.
Prevalence of Internet Gaming Disorder in Medical Students: A Meta-Analysis
Authors: Chiang Christine L. L. , Zhang Melvyn W. B. , Ho Roger C. M. 
Published: January 2022

IntroductionIn the last decade, the technological advances have led to increased usage of the Internet. Internet-based games are now more readily available, and they are also more attractive and engageable for individuals. Previous studies have established university students as vulnerable population with regards to IGD. Despite the unique stressors and demands of the course, there is little information about the pooled prevalence of IGD in medical students.ObjectivesThe current meta-analysis aims to establish the pooled prevalence of IGD among medical students in different countries, and factors affecting the pooled prevalence.MethodsA comprehensive search was conducted from 23 May 2021 to 30 May 2021. The following databases were searched: PubMed, PsychINFO, Cochrane CENTRAL, Google Scholar, Scopus, Web of Science, Embase, Science Direct. The search terminologies included permutations of the keywords for IGD and medical students. All statistical analysis was performed with the Comprehensive Meta-analysis Version 3.0 program based on random-effects model.ResultsThree hundred ninety-six articles were identified from the search of the databases. The final data set consisted of 6 studies with a pooled cohort size of 2,236 medical students. The pooled prevalence of IGD in each country is as follows: Egypt had the highest prevalence rate of 10.9% (95% CI: 7.3–16.1%), followed by Saudi Arabia (8.8, 95% CI: 5.7–13.2%), Indonesia (6.1, 95% CI: 0.7–37.5%) and India (3.8, 95% CI: 2.7–5.5%) (p &lt; 0.005).ConclusionsIn conclusion, this meta-analysis reports that the pooled prevalence of IGD among medical students from different countries is 6.2%, which is around twice as high than that of the general population.
Internal Maxillary Artery-Radial Artery-Middle Cerebral Artery Bypass and STA-MCA Bypass for the Treatment of Complex Middle Cerebral Artery Bifurcation Aneurysm: A Case Report
Authors: Huang Chaojue , Qin Shixing , Cao Guan , Huang Wei , Yu Yongjia 
Published: January 2022

BackgroundChildren's complex middle cerebral artery (MCA) aneurysm is a relatively rare occurrence. When the huge aneurysm is located in the MCA bifurcation with an inconspicuous neck and involving numerous arteries, intravascular interventional surgery or aneurysm clipping are often difficult treatment options. At this point, high flow bypass revascularization is necessary as a treatment to preserve cerebral blood flow. In recent years, the internal maxillary artery (IMA) has gradually become the mainstream donor artery of thw high flow bypass. We performed internal maxillary artery -radial artery-middle cerebral artery (IMA-RA-MCA) and superficial temporal artery-middle cerebral artery (STA-MCA) bypass as the treatment of a complex MCA bifurcation aneurysm in consideration of the patient's condition and the advantage of the IMA. According to the author, this case is the youngest reported case of IMA-RA-MCA bypass at present.Case DescriptionA male child, 7 years and 8 months, was admitted to the hospital due to “recurrent headache for more than 9 months,” DSA indicated that there was a large wide-necked aneurysm at the bifurcation of the right MCA M1 segment, with a size of about 1.16*1.58*1.32 cm. The inflow path of the aneurysm was in front of M1 bifurcation, and one outflow path originated from the aneurysm body, and another small outflow path attached to the aneurysm body. After completing the preoperative evaluation, an extended pterional approach with zygomatic osteotomy was performed to fully expose the aneurysm and IMA, harvesting the left radial artery at the same time, then a STA-MCA bypass, IMA-RA-MCA bypass, and aneurysm trapping were performed. postoperative re-examination showed that bypass vessels and the distal middle artery vessels were patent and the aneurysm disappeared, the child has no neurological dysfunction.ConclusionsIMA-RA-MCA bypass is an effective high-flow cerebral blood reconstruct scheme in the treatment of complex middle cerebral artery bifurcation aneurysms. This case can provide a reference for the surgical treatment of complex middle cerebral artery bifurcation aneurysms in children.
Stres Pada Ibu Bekerja
Authors: Sitorus Friyanka H.D. 
Published: January 2022

Keputusan untuk menjadi ibu rumah tangga atau ibu bekerja, menjadi hal penting bagi banyak wanita. Pada zaman modern ini, wanita yang telah menikah dan berkeluarga umumnya mengkombinasikan tugasnya sebagai ibu dengan kegiatan bekerja karena bekerja telah menjadi bagian dari kehidupan wanita. Berbeda dengan pandangan tradisional dimana wanita hanya memiliki peran untuk melahirkan anak (reproduksi) dan mengurus rumah tangga, seolah dibatasi dan ditempatkan dalam posisi pasif dimana wanita hanyalah pendukung karir suami. Penelitian ini bertujuan untuk melihat gambaran stress pada ibu bekerja secara komprehensif. Penelitian ini menggunakan pendekatan kualitatif yang melibatkan 6 orang ibu pekerja pada rentang usia 20-40 tahun yang memiliki anak dibawah 13 tahun. Hasil penelitian ini menunjukkan bahwa stres pada ibu bekerja umumnya disebabkan oleh faktor eksternal yaitu pekerjaan kemudian disusul dengan kondisi keluarga dan faktor eksternal lainnya. Faktor penahan stres seperti kesehatan dan energi yang tinggi menjadi sumber internal yang meminimalisir dampak dari stres. Sementara self esteem dan interpersonal trust yang tinggi serta komitmen pada keluarga merupakan faktor penahan stres bersumber internal. Implikasi dari penelitian ialah sebagai bentuk pertimbangan dan antisipasi terhadap dampak dari keputusan ibu untuk bekerja mempertimbangkan jumlah ibu bekerja di Indonesia, khususnya Medan, yang semakin meningkat.
KEJADIAN PREMENSTRUAL SYNDROME (PMS) BERDASARKAN KARAKTERISTIK SISWI KELAS XII DI PONDOK PESANTREN SUKOHARJO
Authors: Wijayanti W , Sunarsih Tri , Kartini Farida , Rohmatika Dheny 
Published: January 2022

Premenstrual Syndrome (PMS) adalah gejala fisik, psikologis dan emosi yang terjadi sebelum menstruasi. Dampak yang timbul adalah dapat menganggu aktivitas seorang wanita. Penelitian ini bertujuan untuk mengetahui kejadian premenstrual syndrome (PMS) berdasarkan karakteristik siswi kelas XII di Pondok Pesantren Sukoharjo. Metode penelitian diskriptif dengan analisa kuantitatif, rancangan cross sectional. Subyek penelitian adalah siswi kelas XII dengan PMS di Pondok Pesantren Sukoharjo yang diambil secara total sampling. Hasil dari penelitian yang telah dilakukan adalah bahwa di Pondok Pesantren Sukoharjo dengan responden sebanyak 34 siswi kelas XII dengan PMS, didapatkan hasil yaitu mayoritas umur responden yaitu 17 tahun (70,6%), usia menarche 13-15 tahun (52,9%), lama menstruasi ≥ 7 hari (76,5%), siklus menstruasi 28 hari (76,5%), ganti pembalut ≥ 3 kali perhari (85,3%) dan IMT dengan berat badan ideal (82,4%).
Premenstrual Syndrome (PMS) is a physical, psychological and emotional symptom that occurs before menstruation. The impact that arises is that it can disrupt a woman's activities. This study aims to determine the incidence of premenstrual syndrome (PMS) based on the characteristics of class XII students at the Boarding School Sukoharjo. Descriptive research method with quantitative analysis, cross sectional design. The subjects of the study were students of class XII with PMS at Boarding School Sukoharjo taken in total sampling. The results of the research that has been done is that at the Boarding School Sukoharjo with 34 respondents in class XII with PMS, the results obtained are the majority of respondents' age is 17 years (70.6%), menarche age 13-15 years (52, 9%), menstruation duration ≥ 7 days (76.5%), menstrual cycle 28 days (76.5%), dressing pads ≥ 3 times per day (85.3%) and BMI with ideal body weight (82.4% ).
PENGARUH KEPEMIMPINAN TRANSFORMASIONAL DAN SISTEM REMUNERASI TERHADAP MOTIVASI KERJA YANG BERDAMPAK PADA PRESTASI KERJA PEGAWAI POLITEKNIK LP3I JAKARTA
Authors: Hapsah Enok 
Published: January 2022

<p>The aim of this research is to analyze the influence of transformational leadership and remuneration system on employees performance with work motivation as an intervening variable (research was done at Polytechnic LP3I Jakarta). The amounts of these respondents are 103 employees of Polytechnic LP3I Jakarta. Sampling technique uses Accidental Sampling, and analysis technique uses path analysis, The result of the research shows that transformational leadership has a significant effect on work motivation, remuneration system has a significant effect on work motivation, transformational leadership has significant effect on employees performance, remuneration system has no significant effect on employees performance, work motivation has significant effect on the job performance, transformational leadership and remuneration system has a significant effect on employees work motivation, transformation leadership and remuneration system has a significant effect on employees performance.</p><p><strong>Keywords : </strong>Transformational leadership, remuneration system, employees performance and work motivation.</p>
PROBLEM BASED LEARNING BERPIKIR KRITIS MAHASISWA VOKASI DALAM PEMBELAJARAN DARING
Authors: Astuti Enny Diah , Sintesa Nika 
Published: January 2022

<p> “<em>Problem Based Learning</em> Berpikir Kritis Mahasiswa Vokasi Dalam Pembelajaran Daring” bertujuan untuk mengetahui dan menganalisis <em>problem based learning </em>dalam meningkatkan kemampuan berpikir kritis dan mengembangkan keterampilan mahasiswa vokasi dalam pembelajaran daring. Metode yang dilakukan yaitu metode penelitian deskriptif kualitatif. Peneliti melakukan observasi dan pengumpulan data dalam tiga tahap yang diambil dari 70 mahasiswa vokasi, dalam setiap tahapan dilakukan dalam 2 sesi pertemuan pembelajaran. Analisa data yang dilakukan oleh peneliti adalah dengan menganalisis, menggambarkan, mendeskripsikan berbagai kondisi dan situasi dari data yang dikumpulkan sebagai hasil observasi, wawancara, dan pemetaan kelompok dalam pembelajaran daring. Hasil evaluasi dalam <em>review </em>pembelajaran diperoleh hasil perubahan yang sangat baik. Peningkatan nilai yang diperoleh pada setiap tahap di setiap sesi pembelajaran terlihat bahwa yang pada awalnya mahasiswa belum memahami materi sebanyak 40% berhasil menurun hingga 3%. Pada tahap akhir mahasiswa mulai memahami terhadap materi yang disampaikan oleh dosen yang terlihat peningkatan angka dari semula 60% hingga tercapai 97% Hasil penelitian ini menunjukkan bahwa penerapan <em>problem based learning</em> sangat membantu untuk meningkatkan keterampilan berpikir kritis mahasiswa vokasi selama pembelajaran daring. Kemampuan berpikir kritis sebagai bekal mahasiswa untuk menghadapi perkembangan ilmu pengetahuan dan kemajuan teknologi di masa depan dan sebagai persiapan mahasiswa vokasi untuk terjun ke dalam dunia industri.</p><p class="Style4"><strong>Kata kunci</strong>: <em>Problem Based Learning</em>, Pembelajaran, Berpikir Kritis</p>
Kurunthokail Agamander Uravunilai
Authors: M Kavitha , D Maria Merlin Kavitha 
Published: January 2022

Pattum Thogaiyum are given as Sangam literature. Kuṟunthokai is a classical Tamil poetic work and traditionally the second of the Eight Anthologies (Ettuthokai) in the Sangam literature. The richness of the language and the ability to explain the biology in harmony with the nature of the Sangath Tamil people are great in this Kuruntokai. Love, the most subtle feeling of the human mind, is beautifully and deeply situated in the shorthand. This article summarizes the love relationships that are embedded in the Kuṟuntokai. Although the love of the Hero, the Heroine, the friend, Paangan, the nurse and the narrator is seen in the Kuṟuntokai, more importance is given to the love of the Hero-Heroine. Not only these but also the nature of the prostitutes who are negative members has been studied.
Analysis of self-heating-related instability in n-channel low-temperature polysilicon TFTs with different S/D contact hole densities
Authors: Tu Yu-Fa , Chang Ting-Chang , Zhou Kuan-Ju , Hung Yang-Hao , Zheng Yu-Zhe , Chen Jian-Jie , Tai Mao-Chou , Wang Yu-Xuan , Hung Wei-Chun , Hung Wei-Chieh , Lien Chen-Hsin 
Published: January 2022

Abstract
This study examines self-heating-related instability in n-channel low-temperature polysilicon thin-film transistors with different source/drain contact hole densities. Devices with more contact holes exhibit a higher on-current without additional parasitic capacitance, further enhancing the RC delay property. For high-current-induced self-heating stress, a device with one contact hole has one hump due to the kink effect. However, a device with six contact holes has two humps, induced by the kink effect and thermionic field emission. COMSOL simulations of heat distribution and energy bands are performed to examine the different degradation behaviors, and then physical models are proposed.
Dual-Fano resonances based on all-dielectric toroidal metamaterial
Authors: Xiang Tianyu , Lei Tao , Wu Jiong , Wang Jianwei , Yang Helin 
Published: January 2022

Abstract
Dual-Fano resonances have been proposed with all-dielectric toroidal metamaterials in the microwave frequency. The presented structure consists of high permittivity rectangular bars of equal spacing. Two transparency peaks derived from the strong toroidal dipole with two modes can reach 0.92 and 0.9 at 10.51 GHz and 16.27 GHz, respectively. The excitation of these resonances could be explained by near-field distribution and multipoles scattered power. The trend of experimental results is virtually uniform with that of theoretical analysis and simulated curves. Such a compact all-dielectric structure may have important implications in many fields, such as ultra-sensitive sensors, stealth transmission, and so on.