bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical and dynamic responses of unidirectional/woven carbon fiber reinforced thermoset and thermoplastic composites after low velocity impact
Authors: Kayaaslan Melihcan , Coskun Taner , Sahin Omer Sinan , Unlu Ulac M , Kadioglu Ferhat 
Published: August 2022

It is highly important to determine how mechanical and dynamic properties of composite materials will change after impact loads considering the coupled effects of composite design parameters. For these reasons, three-point bending and vibration tests have been carried out for the carbon fiber reinforced thermoset and thermoplastic composites with various stacking sequences before and after low velocity impact, and it is expected that these results achieved from the current study will be beneficial for applications where high damping and impact resistance are demanded together. In this context, vibration tests were carried out under free-free boundary conditions, and their natural frequencies, flexural moduli and structural damping were obtained. Furthermore, three-point tests were conducted in the elastic region with 1 mm/min crosshead speed using a universal test machine, and thus flexural moduli of the composite specimens were obtained. The results were validated by comparing the flexural moduli obtained from the both vibration and three-point bending tests, found to be reliable and comparable. As a result of the current study, it was concluded that woven fabric reinforced composite specimens exhibited 50% higher specific damping capacity (SDC) but 70% lower flexural modulus than unidirectional specimens thanks to biaxially fiber alignment. On the other hand, specific damping capacities of the thermoset and thermoplastic composites with different stacking sequences have been examined, and it was observed that thermoset specimens exhibited unexpectedly 192% higher SDC compared to the thermoplastics. This was interpreted as even though thermoplastics are normally expected to exhibit more damping than thermosets, stacking sequence being more effective on damping responses. Apart from that, although there were slight changes in material properties due to degradation in structural integrity after 2 m/s and 3 m/s low-velocity impacts, it was not found to be significantly effective due to the limited damage areas.
Differential vulnerability of thalamic nuclei in multiple sclerosis
Authors: Blyau Simon , Koubiyr Ismail , Saranathan Manojkumar , Coupé Pierrick , Deloire Mathilde , Charré-Morin Julie , Saubusse Aurore , Zhang Bei , Rutt Brian , Dousset Vincent , Brochet Bruno , Ruet Aurélie , Tourdias Thomas 
Published: August 2022

Objectives: Investigating differential vulnerability of thalamic nuclei in multiple sclerosis (MS). Methods: In a secondary analysis of prospectively collected datasets, we pooled 136 patients with MS or clinically isolated syndrome and 71 healthy controls all scanned with conventional 3D-T1 and white-matter-nulled magnetization-prepared rapid gradient echo (WMn-MPRAGE) and tested for cognitive performance. T1-based thalamic segmentation was compared with the reference WMn-MPRAGE method. Volumes of thalamic nuclei were compared according to clinical phenotypes and cognitive profile. Results: T1- and WMn-MPRAGE provided comparable segmentations (0.84 ± 0.13 < volume-similarity-index < 0.95 ± 0.03). Medial and posterior thalamic groups were significantly more affected than anterior and lateral groups. Cognitive impairment related to volume loss of the anterior group. Conclusion: Thalamic nuclei closest to the third ventricle are more affected, with cognitive consequences.
‘Autistic person’ or ‘person with autism’? Person-first language preference in Dutch adults with autism and parents
Authors: Buijsman Riley , Begeer Sander , Scheeren Anke M 
Published: August 2022

The language used to refer to autism has been a topic of ongoing debate. Research in English-speaking countries indicated an overall preference for identity-first language (‘autistic person’) among autistic adults rather than person-first language (‘person with autism’). We examined terminology preference in Dutch autistic adults ( n = 1026; 16–84 years; 57% women) and parents of autistic children ( n = 286) via an online survey. A majority of self-reporting adults with autism (68.3%) and parents (82.5%) demonstrated a person-first language preference. A younger age, higher IQ and more autistic traits predicted a relatively stronger identity-first language preference in autistic adults. We conclude that language and culture may impact terminology preference of adults with autism and parents. For now, we advocate to use a mix of person-first language and identity-first language in academic papers to cover the full range of preferences. Lay abstract There are different words to describe people with an autism diagnosis. For instance, we can put the person before autism (e.g. ‘person with autism’), or we can put autism before the person (e.g. ‘autistic person’). Previous research showed that autistic adults in English-speaking countries generally liked it better when autism is placed before the person. Yet, people also greatly differ in the words they like and dislike. In this study, we examined word preference in Dutch autistic adults ( n = 1026; 16–84 years; 57% women) and parents of autistic children ( n = 286). Via an online questionnaire, we asked our participants to select one term for autistic people that they liked best. The results showed that most adults with autism (68.3%) and parents (82.5%) preferred to put the person before autism. Younger adults, with a higher intelligence, and with more autistic traits, were a bit more likely to put autism before the person. We conclude that there are large differences in the words that people prefer. Because we found different results in our Dutch participants compared to participants in English-speaking countries, we think that the Dutch language or culture may also play a role in word preference. For now, we advise autism researchers to use both person-first and autism-first language.
How Are Women Faring in the Bangladeshi Labour Market? Evidence from Labour Force Survey Data
Authors: Bidisha Sayema Haque , Faruk Avinno , Mahmood Tanveer 
Published: August 2022

In Bangladesh, despite increased participation in the labour market in recent decades, women are still lagging behind men by a significant margin, with the former being concentrated chiefly in low-paid agriculture as well as in the lower stages of the occupational ladder. With the help of the latest labour market data of 2016–2017 coupled with 2011 census data, this article attempts to examine gender segregation through sectoral and occupational lenses. Our econometric estimation of different sectors (agriculture, manufacturing, construction and service) reflects the importance of gender-centric factors such as care burden and marital status along with local employment opportunities in constraining women’s labour market engagement. Besides, decomposition analysis highlights that unfavourable returns to endowments play a crucial role in females’ concentration in relatively low-productive sectors. Sectoral and occupational segregation indices reflect a high degree of segregation between men and women. Thus, against the backdrop of the concentration of women in low-skilled jobs and a low-productive sector, this article expects to provide important policy insights for boosting female employment in relatively high-productive sectors and high-paid occupations while utilizing the structural shift in the labour market of Bangladesh. JEL Classifications: J16, J21, J71, J62, C25, O53
30 s sit-to-stand power is positively associated with chest muscle thickness in COVID-19 survivors
Authors: Núñez-Cortés Rodrigo , Cruz-Montecinos Carlos , Martinez-Arnau Francisco , Torres-Castro Rodrigo , Zamora-Risco Esteban , Pérez-Alenda Sofía , Andersen Lars L. , Calatayud Joaquín , Arana Estanislao 
Published: August 2022

Introduction After hospitalization, early detection of musculoskeletal sequelae might help healthcare professionals to improve and individualize treatment, accelerating recovery after COVID-19. The objective was to determine the association between the 30s sit-to-stand muscle power (30s-STS) and cross-sectional area of the chest muscles (pectoralis) in COVID-19 survivors. Method This cross-sectional study collected routine data from COVID-19 survivors one month after hospitalization: 1) a chest computed tomography (CT) scan and 2) a functional capacity test (30s-STS). The pectoralis muscle area (PMA) was measured from axial CT images. For each gender, patients were categorized into tertiles based on PMA. The 30s-STS was performed to determine the leg extension power. The allometric and relative STS power were calculated as absolute 30s-STS power normalized to height squared and body mass. The two-way ANOVA was used to compare the gender-stratified tertiles of 30s-STS power variants. Results Fifty-eight COVID-19 survivors were included (mean age 61.2 ± 12.9 years, 30/28 (51.7%/48.3%) men/women). The two-way ANOVA showed significant differences between the PMA tertiles in absolute STS power ( p = .002) and allometric STS power ( p = .001). There were no significant gender x PMA tertile interactions (all variables p > .05). The high tertile of PMA showed a higher allometric STS power compared to the low and middle tertile, p = .002 and p = .004, respectively. Absolute STS power and allometric STS power had a moderate correlation with the PMA, r = 0.519 ( p < .001) and r = 0.458 ( p < .001) respectively. Conclusion The 30s-STS power is associated with pectoralis muscle thickness in both male and female COVID-19 survivors. Thus, this test may indicate global muscle-wasting and may be used as a screening tool for lower extremity functional capacity in the early stages of rehabilitation planning in COVID-19 survivors.
HIV/AIDS risk-reduction options as predictor of female sex workers’ sexual behaviour
Authors: Lake Yimer Beneyam 
Published: August 2022

Background: Sex workers are highly vulnerable to HIV infection and suitable transmission groups in the scope of the HIV epidemic. The study investigated the association among HIV/AIDS risk-reduction options as predictors of female sex workers’ behaviour. Methods: The study used a cross-sectional research design. The quantitative survey involved 140 women, who were selected using simple random sampling techniques. Results: The findings of the study show that looking for a job, disagreement in the family, death of parents, peer pressure, and attraction of town life were indicated as major pulling and pushing factors for sex worker engagement. The majority of respondents is aware of HIV/AIDS and practice HIV/AIDS risk-reduction options. Conclusion: Age, alcohol use, difficult to negotiate with clients to use condoms, and disapproval of clients to use condoms were significant predictors of consistent condom-using behaviours of female sex workers. This study recommended that life skills training and existing strategies enable sex workers to develop skills that help them resist the pressures that come from their clients.
Nab-paclitaxel plus S-1 versus oxaliplatin plus S-1 as first-line treatment in advanced gastric cancer: results of a multicenter, randomized, phase III trial (GAPSO study)
Authors: Dai Yu-Hong , Yu Xiong-Jie , Xu Hui-Ting , Zhuang Liang , Zhang Ming-Sheng , Zou Yan-Mei , Fu Qiang , Qiu Hong , Yuan Xiang-Lin 
Published: August 2022

Background: This study aimed to investigate the superiority of nab-paclitaxel plus S-1 (AS) over oxaliplatin plus S-1 (SOX) in patients with advanced gastric cancer (AGC). Methods: In this multicenter, randomized, phase III superiority trial, eligible patients with unresectable, locally advanced gastric adenocarcinoma were recruited and randomly assigned (1:1) to receive AS ( nab-paclitaxel 260 mg/m2 on day 1 or 130 mg/m2 on days 1 and 8; oral S-1 40–60 mg twice daily for 14 days) or SOX (130 mg/m2 oxaliplatin on day 1; oral S-1 40–60 mg twice daily for 14 days) every 3 weeks for up to six cycles. The primary endpoint was progression-free survival (PFS), and the secondary endpoints were overall survival, objective response rate, and safety. Results: Owing to slow enrolment, an unplanned interim analysis was performed, resulting in the early termination of the study on 31 December 2021 (data cutoff). Between March 2019 and March 2021, 97 patients (AS, n = 48; SOX, n = 49) were treated and evaluated for efficacy and safety of AS and SOX. As of the data cutoff, the median follow-up was 23.13 months [95% confidence interval (CI), 13.39–32.87]. The median PFS was 9.03 months (95% CI, 6.50–11.56) in the AS group and 5.07 months (95% CI, 4.33–5.81) in the SOX group, demonstrating a better PFS tendency following AS treatment than SOX treatment (hazard ratio = 0.59; 95% CI, 0.37–0.94; p = 0.03). The most common grade 3 or worse adverse events were anemia, neutropenia, and leukopenia in both groups, with a higher incidence of thrombocytopenia in the SOX group. Conclusion: Although this study was terminated early, the results demonstrated a better PFS tendency in patients with AGC who were treated with AS than in those treated with SOX, with controllable toxicities. Trial registration: Clinical Trials.gov identifiers: NCT03801668. Registered January 11, 2019.
Low-dose apatinib combined with neoadjuvant chemotherapy in the treatment of early-stage triple-negative breast cancer (LANCET): a single-center, single-arm, phase II trial
Authors: Yang Ciqiu , Zhang Junsheng , Zhang Yi , Ji Fei , Chen Yitian , Zhu Teng , Zhang Liulu , Gao Hongfei , Yang Mei , Li Jieqing , Cheng Minyi , Wang Kun 
Published: August 2022

Background: Antiangiogenic therapy combined with chemotherapy could improve pathological complete response (pCR) for breast cancer. Apatinib is an oral tyrosine kinase inhibitor that selectively inhibits vascular endothelial growth factor receptor 2. We assessed the efficacy and safety of apatinib combined with standard neoadjuvant chemotherapy in patients with triple-negative breast cancer (TNBC). Materials and methods: This single-arm, phase II study enrolled patients aged 18–70 years with previously untreated stage IIA-IIIB TNBC. Patients received oral apatinib at a dose of 250 mg once daily and intravenously docetaxel every 3 weeks for four cycles, followed by epirubicin plus cyclophosphamide every 3 weeks for four cycles. The primary endpoint was the pCR rate in the breast and lymph nodes. Secondary endpoints included objective response rate, event-free survival (EFS), overall survival (OS), and safety. Results: In all, 31 patients were enrolled, and the median follow-up time was 22.9 months (range: 10.1–41.6 months). The pCRs in both breast and lymph nodes were achieved in 17 [54.8%; 95% confidence interval (CI): 36.0–72.7] of 31 patients. Objective responses were achieved in 29 patients (93.5%; 95% CI: 78.6–99.2), and disease control was achieved in 31 patients (100%; 95% CI: 88.8–100.0). The 2-year EFS and 2-year OS were 90.9% and 94.4%, respectively. The five most common treatment-related adverse events were fatigue (51%), hypertension (41%), anorexia (39%), hand–foot syndrome (35%), and diarrhea (32%). Few grade 3 or more adverse events were observed. Conclusion: The combination of apatinib with docetaxel followed by epirubicin plus cyclophosphamide showed excellent efficacy and manageable toxicities; and further randomized controlled phase III trials are warranted. Trial registration: This trial was registered with ClinicalTrials.gov (NCT03243838) on 5 August 2017.
Goal-directed upper limb movement patterns and hand grip forces in multiple sclerosis
Authors: Kanzler Christoph M , Sylvester Ramona , Gassert Roger , Kool Jan , Lambercy Olivier , Gonzenbach Roman 
Published: August 2022

Background Upper limb disability in persons with Multiple Sclerosis (pwMS) leads to increased dependence on caregivers. To better understand upper limb disability, observer-based or time-based clinical assessments have been applied. However, these only poorly capture the behavioural aspects underlying goal-directed task performance. Objective We aimed to document alterations in goal-directed upper limb movement patterns and hand grip forces in a cohort of pwMS (n = 123) with mild to moderate upper limb impairments. Methods We relied on the Virtual Peg Insertion Test (VPIT), a technology-aided assessment with a goal-directed pick-and-place task providing a set of validated digital health metrics. Results All metrics indicated significant differences to an able-bodied reference sample (p < 0.001), with smoothness, speed, and grip force control during object manipulation being most affected in pwMS. Such abnormalities negatively influenced the time to complete the goal-directed task (p < 0.001, R2 = 0.77), thereby showing their functional relevance. Lastly, abnormalities in movement patterns and grip force control were consistently found even in pwMS with clinically normal gross dexterity and grip strength. Conclusion This work provides a systematic documentation on goal-directed upper limb movement patterns and hand grip forces in pwMS, ultimately paving the way for an early detection of MS sign using digital health metrics.
Increased Risk of ACL Injury for Female but Not Male Soccer Players on Artificial Turf Versus Natural Grass: A Systematic Review and Meta-Analysis
Authors: Xiao Michelle , Lemos Jacie L. , Hwang Calvin E. , Sherman Seth L. , Safran Marc R. , Abrams Geoffrey D. 
Published: August 2022

Background: Both natural grass (NG) and artificial turf (AT) are popular playing surfaces for soccer. Biomechanical studies have found increased frictional forces on AT that may lead to anterior cruciate ligament (ACL) injury. The increased risk of ACL injury during soccer in female participants may amplify this effect. Purpose: To systematically review the literature for studies comparing ACL injury risk in soccer players on AT versus NG and to specifically determine whether there were differences in injury risk in male versus female players when considering the playing surface. Study Design: Systematic review; Level of evidence, 3. Methods: A systematic review was performed using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Three databases were searched for studies with evidence level 1 to 3 that compared the incidence of ACL injuries on AT versus NG in soccer players. Data recorded included study characteristics, sex, competition level, exposure setting (games or practices), turf type, and ACL injury information. Study methodological quality was analyzed using the methodological index for non-randomized studies (MINORS) score, and incidence rate ratios (IRRs) were calculated. Results: Included were 7 articles (3 studying professional soccer, 3 collegiate soccer, 1 youth-level soccer; 4 male cohorts, 2 female cohorts, and 1 male and female cohort; mean MINORS score, 20 ± 0.8). Pooled ACL injury IRRs demonstrated no significant differences in overall ACL injury risk when playing soccer on AT compared with NG (IRR = 0.57 [95% CI, 0.21-1.53]; P = .31). A significantly increased risk of ACL injury in games played on AT compared with NG was detected for female (IRR = 1.18 [95% CI, 1.05-1.31]; P = .004) but not for male players (IRR = 1.18 [95% CI, 0.97-1.42]; P = .09). Subgroup analyses showed no significant differences in injury risk for games (IRR = 1.07 [95% CI, 0.97-1.18]; P = .20) or practices (IRR = 0.21 [95% CI, 0.04-1.23]; P = .09). Conclusion: Findings indicated that female soccer players had a significantly higher risk of ACL injury when playing games on AT versus NG, whereas no significant difference was seen in male players. No differences were found for the combined male/female cohort or for soccer games or training sessions played on AT compared with NG.
Midterm Outcomes After Revision Posterior Cruciate Ligament Reconstruction With a Single-Bundle Transtibial Autograft
Authors: Chen Yi-Jou , Yang Cheng-Pang , Ho Chin-Shan , Weng Chun-Jui , Chen Alvin Chao-Yu , Hsu Wei-Hsiu , Hsu Kuo-Yao , Chan Yi-Sheng 
Published: August 2022

Background: There is a lack of consensus regarding the optimal technique for revision posterior cruciate ligament (PCL) reconstruction. Purpose: To evaluate midterm outcomes after revision PCL reconstruction using a single-bundle transtibial autograft. Study Design: Case series; Level of evidence, 4. Methods: We reviewed 17 patients who underwent revision PCL reconstruction performed in our medical center by a single surgeon from 2003 to 2016. The cohort included 12 male and 5 female patients with a mean age of 31.3 years (range, 17-48 years). All of the patients underwent single-bundle transtibial reconstruction using the same surgical technique and were reviewed at a minimum of 4 years postoperatively. Preoperative and postoperative posterior stress radiography was performed. The preoperative tibial slope and tibiofemoral angle were also measured. Preoperative and postoperative functional outcomes were evaluated using the International Knee Documentation Committee (IKDC) subjective and objective scores as well as the Lysholm score. Results: The most common factor that contributed to the failure of primary surgery was misplaced tunnels, especially on the femoral side. There were 2 patients who had grade 2 laxity preoperatively, and 15 patients had grade 3 laxity preoperatively. At the latest follow-up, all 17 patients had grade 1 laxity. On posterior stress radiography, posterior displacement improved from 10.8 ± 2.1 mm preoperatively to 2.9 ± 1.1 mm at the latest follow-up ( P < .001). The IKDC subjective score improved from 34.9 ± 6.8 preoperatively to 75.3 ± 15.7 postoperatively ( P < .001), and the Lysholm score improved from 38.1 ± 10.0 preoperatively to 88.5 ± 7.6 postoperatively ( P < .001). All patients reached the minimal clinically important difference (MCID) for the Lysholm score, and 94% reached the MCID for the IKDC subjective score, with 65% reaching the Patient Acceptable Symptom State. Conclusion: According to the findings of this study, arthroscopic revision PCL reconstruction with a single-bundle transtibial autograft offered satisfactory outcomes at midterm follow-up.