bluuebunny/crossref_metadata_2025_split huggingface dataset:
STRATEGI PENDIDIKAN ISLAM DALAM MENINGKATKAN KUALITAS SUMBER DAYA MANUSIA PERSPEKTIF ZAKIAH DARADJAT
Authors: Ulya Neng , Ramadhani Khalid 
Published: February 2022

Realitas Pendidikan Islam saat ini bisa dibilang telah mengalami masa intellectual deadlock. Hal tersebut terjadi karena akibat dari minimnya upaya pembaharuan dan praktek pendidikan Islam sejauh ini masih memelihara warisan yang lama dan tidak banyak melakukan pemikiran kreatif, inovatif dan kritis terhadap isu-isu aktual. Selain itu, model pembelajaran pendidikan Islam terlalu menekankan pada pendekatan intelektualisme-verbalistik dan menegasikan pentingnya interaksi edukatif dan komunikasi humanistik antara guru-murid. Jenis penelitian yang dilakukan adalah penelitian kepustakaan (library research). Data-data yang dikumpulkan berasal dari tulisan-tulisan Zakiah Daradjat sebagai data utama (primer) dan sumber-sumber lainnya yang relevan dengan pembahasan sebagai data sekunder, baik itu berupa buku, majalah, artikel, makalah, hasil-hasil penelitian ataupun buletin yang ada kaitannya dengan penelitian ini.
Dari hasil penelitian pemikiran Zakiah Daradjat tentang strategi pendidikan Islam dalam meningkatkan kualitas sumber daya manusia (SDM), dapat di sederhanakan menjadi :Pertama, Konsep Strategi pendidikan Islam menurut Zakiah Daradjat untuk meningkatkan kualitas SDM terdiri dari dua model, yaitu strategi pendidikan yang bersifat makro dan strategi pendidikan yang bersifat mikro. Kedua, Manusia merupakan makhluk yang memiliki kemampuan istimewa di antara makhluk lainnya. Agar umat islam berperan aktif dan survive di era globaliasasi, Menpunyai keterampilan untuk melaksanakan peranan kemasyarakatan dengan baik, dan berakhlak mulia. dalam bidang sokial, politik, dan kemajuan iptek. Ketiga, Starategi pendidikan Islam yang digagas Zakiah Daradjat ,Potensi-potensi yang diberikan kepada manusia pada dasarnya merupakan petunjuk (hidayah) Allah yang diperuntukkan bagi manusia supaya ia dapat melakukan sikap hidup yang serasi dengan hakekat penciptaannya.
MATEMATIKA DALAM AKSIOLOGI
Authors: Marliani Marliani 
Published: February 2022

Penelitian ini dilatarbelakangi oleh adanya beberapa orang yang kurang mengabdi pada matematika, hal ini dapat diamati oleh setiap guru matematika bahwa dalam suatu kelas siswa yang diperkirakan berjumlah sekitar tiga puluh orang, yang paling dominan dan yang paling dominan adalah siswanya. siswa yang serius seperti matematika berkisar dari sekitar tujuh siswa. Selanjutnya jika matematika dikaitkan dengan kajian aksiologi (implementasi) dalam filsafat ilmu, maka manfaat mempelajari matematika dalam kehidupan sehari-hari sangat bermanfaat bagi siswa, terutama dalam praktik jual beli di warung, di pasar dan berbagai kegiatan ekonomi lainnya. kegiatan di masyarakat. Tujuan dari penelitian ini adalah untuk mengetahui konsep aksiologi dalam filsafat ilmu dan konteksnya dalam mempelajari matematika serta untuk mengetahui titik keterkaitan manfaat matematika dengan kehidupan sehari-hari di masyarakat. Penelitian ini menggunakan metode penelitian kepustakaan dan juga eksperimen. Yaitu metode kepustakaan yang dilakukan untuk mengumpulkan data-data yang berkaitan dengan penelitian sebelumnya, sedangkan dilakukan dengan mengambil sampel praktik pembelajaran di sekolah dimana peneliti menjadi guru matematika di MTsN 2 Palangka Raya.
Hasil penelitian ini adalah konsep aksiologi dalam filsafat ilmu yaitu implementasi dari ilmu yang telah dipelajari dari pelajaran matematika ternyata memiliki nilai manfaat yang sangat besar bagi setiap orang, adapun kegunaan matematika bagi kehidupan sehari-hari, ternyata matematika memiliki banyak manfaat. dan nilai positif dalam menunjang kehidupan manusia di bidang ekonomi.
Ansiedad dental y pensamientos automáticos en pacientes odontológicos de la Cruz Roja, provincia de Tungurahua
Authors: Lara-Machado Juana Rosario , Lara-Barros Betsabe Patricia 
Published: February 2022

INTRODUCCIÓN. Se observó deficiencia de información en cuanto a la relación entre los pensamientos automáticos y el miedo al dentista, el cual es la razón principal para evitar o posponer el tratamiento odontológico comprometiendo la salud oral. OBJETIVO. Examinar la correlación entre los niveles de ansiedad dental y los pensamientos automáticos en los pacientes odontológicos de la Cruz Roja en la provincia de Tungurahua. MÉTODO. Estudio no experimental de tipo transversal con alcance explicativo, correlacional. Se emplearon tres escalas: Kleinknecht Dental Fear Scale (DFS), la Encuesta de Ansiedad Dental Modificada de Corah (MDAS) y el Inventario Automático de Pensamientos de Ruíz y Luján mientras que el análisis estadístico se realizó mediante alfa de Cronbach. RESULTADOS. El análisis demostró que los pensamientos automáticos más comunes son: filtraje (51%), falacia de razón (54%), falacia de recompensa divina (54%) y "debería" (50%). Así también, el 65.9% presentó niveles moderados de miedos dentales y el 46.2% niveles de ansiedad dental leve. DISCUSIÓN Y CONCLUSIONES. Los resultados revelaron que los niveles de ansiedad dental varían en términos del procedimiento dental que han experimentado los pacientes y el bajo nivel de ansiedad se relaciona con el elemento relacional del profesional.
Effectiveness and Safety of a Prolonged Hemodynamic Support by the IVAC2L System in Healthy and Cardiogenic Shock Pigs
Authors: Delmas Clément , Porterie Jean , Jourdan Géraldine , Lezoualc'h Frank , Arnaud Romain , Brun Stéphanie , Cavalerie Hugo , Blanc Grégoire , Marcheix Bertrand , Lairez Olivier , Verwaerde Patrick , Mialet-Perez Jeanne 
Published: February 2022

BackgroundMechanical circulatory supports are used in case of cardiogenic shock (CS) refractory to conventional therapy. Several devices can be employed, but are limited by their availability, benefit risk-ratio, and/or cost.AimsTo investigate the feasibility, safety, and effectiveness of a long-term support by a new available device (IVAC2L) in pigs.MethodsExperiments were carried out in male pigs, divided into healthy (n = 6) or ischemic CS (n = 4) groups for a median support time of 34 and 12 h, respectively. IVAC2L was implanted under fluoroscopic and TTE guidance under general anesthesia. CS was induced by surgical ligation of the left anterior descending artery. An ipsilateral lower limb reperfusion was created with the Solopath® system. Reperfusion was started after 1 h of support in healthy pigs and upon IVAC2L insertion in CS pigs. Hemodynamic and biological parameters were monitored before and during the whole period of support in each group.ResultsOccurrence of an ipsilateral lower limb ischemia was systematic in healthy and CS pigs in a few minutes after IVAC2L implantation, and could be reversed by the arterial reperfusion, as demonstrated by distal transcutaneous pressure in oxygen (TcPO2) and lactate normalization. IVAC2L support decreased pulmonary capillary wedge pressure (PCWP) (15.3 ± 0.3 vs. 7.5 ± 0.9 mmHg, p &lt; 0.001), increased systolic blood pressure (SBP) (70 ± 4.5 vs. 101.3 ± 3.1 mmHg, p &lt; 0.01), and cardiac output (CO) (4.0 ± 0.3 vs. 5.2 ± 0.6 l/min, p &lt; 0.05) in CS pigs; at CS onset and after 12 h of support, without effects on heart rate or pulmonary artery pressure (PAP). Non-sustained ventricular arrhythmias were frequent at implantation (50%). A non-significant hemolysis was observed under support in CS pigs. Bleedings were frequent at the insertion and/or operating sites (30%).ConclusionLong-term support by IVAC2L is feasible and associated with a significant hemodynamic improvement in a porcine model. These preclinical data open the door for a study of IVAC2L in human ischemic CS, keeping in mind the need for systematic reperfusion of the lower limb and the associated risk of bleeding.
Dissecting the Association of Apolipoprotein E Gene Polymorphisms With Type 2 Diabetes Mellitus and Coronary Artery Disease
Authors: Wu Lei , Zhang Yan , Zhao Hong , Rong Guodong , Huang Peijun , Wang Fang , Xu Ting 
Published: February 2022

BackgroundApolipoprotein E (APOE) gene mediates lipoprotein clearance and is one of the most studied candidate genes for type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD). This study was performed to determine the association between APOE polymorphisms and T2DM with and without CAD, and its effect on plasma lipid levels in a Chinese population.MethodsA total of 1,414 subjects involving 869 patients and 545 health individuals were recruited. These patients were categorized into three distinct groups: 264 in T2DM group, 401 in CAD group, and 204 in T2DM+CAD group. Logistic regression analysis was used to obtain odds ratio (OR) and 95% confidence interval (CI) in predicting the risk probability of APOE. Besides, a meta-analysis was preformed to integrate an evaluation index to evaluate their associations.ResultsGenotype frequency ratio of genotype ϵ3/4 and allele ϵ4 among the CAD patients with or without T2DM was obviously increased. Compared with ϵ3/3 genotype, the ϵ3/4 genotype had a significant increased risk of CAD (adjusted OR = 1.90, 95% CI = 1.30–2.77) and T2DM+CAD (adjusted OR = 1.95, 95% CI = 1.24–3.08). In the meta-analysis, four studies were included and provided a strong evidence for the APOE ϵ4 mutation elevating the risk of CAD in patients with T2DM (ϵ3/ϵ4+ϵ4/ϵ4 vs. ϵ3/ϵ3, OR = 1.51, 95% CI = 1.13–2.02). In the T2DM group, the plasma levels of low-density lipoprotein cholesterol (LDL-C) showed significant difference among the three APOE isoforms. The high-density lipoprotein cholesterol (HDL-C) levels of CAD patients with ϵ4-bearing genotypes were lower than those with ϵ3/3 genotype.ConclusionsOur results indicate that APOE gene polymorphisms are related to CAD with or without T2DM and have influence on lipid profiles in both T2DM and CAD patients.
Development and External Validation of a Dynamic Nomogram With Potential for Risk Assessment of Ruptured Multiple Intracranial Aneurysms
Authors: Chen TingTing , Xiong WeiGen , Zhao ZhiHong , Shan YaJie , Li XueMei , Guo LeHeng , Xiang Lan , Chu Dong , Fan HongWei , Li YingBin , Zou JianJun 
Published: February 2022

Background and PurposeAbout 20.1% of intracranial aneurysms (IAs) carriers are multiple intracranial aneurysms (MIAs) patients with higher rupture risk and worse prognosis. A prediction model may bring some potential benefits. This study attempted to develop and externally validate a dynamic nomogram to assess the rupture risk of each IA among patients with MIA.MethodWe retrospectively analyzed the data of 262 patients with 611 IAs admitted to the Hunan Provincial People's Hospital between November 2015 and November 2021. Multivariable logistic regression (MLR) was applied to select the risk factors and derive a nomogram model for the assessment of IA rupture risk in MIA patients. To externally validate the nomogram, data of 35 patients with 78 IAs were collected from another independent center between December 2009 and May 2021. The performance of the nomogram was assessed in terms of discrimination, calibration, and clinical utility.ResultSize, location, irregular shape, diabetes history, and neck width were independently associated with IA rupture. The nomogram showed a good discriminative ability for ruptured and unruptured IAs in the derivation cohort (AUC = 0.81; 95% CI, 0.774–0.847) and was successfully generalized in the external validation cohort (AUC = 0.744; 95% CI, 0.627–0.862). The nomogram was calibrated well, and the decision curve analysis showed that it would generate more net benefit in identifying IA rupture than the “treat all” or “treat none” strategies at the threshold probabilities ranging from 10 to 60% both in the derivation and external validation set. The web-based dynamic nomogram calculator was accessible on https://wfs666.shinyapps.io/onlinecalculator/.ConclusionExternal validation has shown that the model was the potential to assist clinical identification of dangerous aneurysms after longitudinal data evaluation. Size, neck width, and location are the primary risk factors for ruptured IAs.
Sleep Quality and Insomnia Are Associated With Quality of Life in Functional Dyspepsia
Authors: Wuestenberghs Fabien , Melchior Chloé , Desprez Charlotte , Leroi Anne-Marie , Netchitailo Marie , Gourcerol Guillaume 
Published: February 2022

BackgroundSleep disturbances are common in patients with functional dyspepsia. Our aim was to assess the relationship between subjective sleep and quality of life and to identify factors associated with impaired sleep in functional dyspepsia.MethodsOne thousand two hundred and twenty patients referred for functional gastrointestinal disorders at a single tertiary care center between end 2017 and June 2019 were studied using a self-administered questionnaire. 355 patients with Rome IV-based functional dyspepsia were identified. Sleep was assessed using both the Pittsburgh Sleep Quality Index (PSQI) and the Insomnia Severity Index (ISI). The severity of dyspeptic symptoms was assessed using the Total Symptom Score (TSS). Quality of life was assessed by the GastroIntestinal Quality of Life Index (GIQLI). Anxiety and depression levels were evaluated using the Hospital Anxiety and Depression (HAD) scale.Key ResultsAmong the 355 patients with functional dyspepsia, 66 (18.6%) patients displayed normal sleep quality whereas 289 (81.4%) patients had altered sleep quality. Functional dyspepsia patients with sleep disturbances were older (48.1 ± 15.4 vs. 41.4 ± 16.0, p = 0.0009), had decreased quality of life (GIQLI: 75.3 ± 18.5 vs. 92.1 ± 15.4, p &lt; 0.0001), greater severity of their symptoms (TSS: 18.9 ± 3.6 vs. 17.2 ± 3.9, p = 0.0007), and higher anxiety and depression scores (HADS: 17.7 ± 7.2 vs. 11.9 ± 5.1, p &lt; 0.0001). A correlation was found between sleep quality and quality of life [r = −0.43 (95% CI: −0.51 to −0.34), p &lt; 0.0001]. Independent factors predicting poor sleep quality were age [OR 1.03 (95% CI = 1.01–1.05), p = 0.006], depression level [OR 1.27 (95% CI = 1.16–1.39); p &lt; 0.0001], and the severity of dyspeptic symptoms [OR 1.13 (95% CI = 1.04–1.22); p = 0.004].Conclusion and InferencesA high prevalence of sleep disturbances was found in patients suffering from functional dyspepsia, with 81% of them having altered sleep quality and 61% having insomnia based on subjective assessment. Altered sleep quality and insomnia were associated with altered quality of life, higher severity of symptoms, and higher anxiety and depression scores in this disorder.
Stachytine Hydrochloride Improves Cardiac Function in Mice with ISO-Induced Heart Failure by Inhibiting the α-1,6-Fucosylation on N-Glycosylation of β1AR
Authors: Hu Panwei , Guo Shuting , Yang Songru , Wang Sining , Wang Sai , Shan Xiaoli , Zhao Pei , Guo Wei , Xu Ming , Zhang Chen , Lu Rong , Chen Huihua 
Published: February 2022

Background: Cardiovascular diseases have become a major public health problem that seriously threatens human health. The cumulative effects of various cardiovascular events will eventually develop into chronic heart insufficiency and even heart failure, and the β1 adrenergic receptor signal pathway plays an important role in this process. Stachytine hydrochloride is the main active ingredient of Yimucao, which is a traditional Chinese medicine used to treat gynecological diseases. Modern studies have found that stachytine hydrochloride has a good cardioprotective effect, but it is still unclear whether stachytine hydrochloride has an effect on the β1 adrenergic receptor signal pathway. The purpose of this study is to explore the effect of stachytine hydrochloride on the β1 adrenergic receptor signal pathway.Method: In this study, a continuous infusion of isoproterenol (40 mg/kg/day) was administered to mice and ventricular myocytes explored the potential mechanism of stachytine hydrochloride (12 mg/kg/day) on the β1 adrenergic receptor signal pathway in the heart. Evaluate changes in cardiac morphology and function by echocardiography, cardiac hemodynamics, and histological methods, and detect molecular changes by Western blot and immunofluorescence. Treat primary cultured adult mouse or neonatal rat ventricular myocytes with or without isoproterenol (0.1 μMol), PNGase F (10–2 units/ml), and stachytine hydrochloride (10 μMol) at different time points. Detect α-1,6-fucosylation on N-glycosylation, calcium transient, contraction, and relaxation function and related signals.Results: Stachytine hydrochloride reduces cardiac remodeling and modulates hemodynamic parameters during chronic β1 adrenergic receptor activation in vivo. The N-glycosylation of β1 adrenergic receptors decreased after continuous isoproterenol stimulation, while stachytine hydrochloride can increase the N-glycosylation of β1AR in the heart of mice with isoproterenol-induced heart failure. Decreased N-glycosylation of β1 adrenergic receptors will downregulate the cAMP/PKA signal pathway and inhibit myocardial excitation and contraction coupling. Stachytine hydrochloride significantly reduced isoproterenol-induced cardiac N-linked glycoproteins with α-1,6-fucosylation.Conclusion: Our results show that stachytine hydrochloride inhibits the synthesis of α-1,6-fucosylation on the N-terminal sugar chain by reducing α-1,6-fucosyltransferase (FUT8) and α-1,3-mannosyl-glycoprotein 4-β-N-acetylglucosaminyltransferase A (MGAT4a), upregulating the N-glycosylation level on β1 adrenergic receptors, and maintaining cAMP/PKA signal pathway activation.
Clinical Parameters and Metabolomic Biomarkers That Predict Inhospital Outcomes in Patients With ST-Segment Elevated Myocardial Infarctions
Authors: Liu Jie , Huang Lei , Shi Xinrong , Gu Chungang , Xu Hongmin , Liu Shuye 
Published: February 2022

BackgroundPostoperative risk stratification is challenging in patients with ST-segment elevation myocardial infarction (STEMI) who undergo percutaneous coronary intervention. This study aimed to characterize the metabolic fingerprints of patients with STEMI with different inhospital outcomes in the early stage of morbidity and to integrate the clinical baseline characteristics to develop a prognostic prediction model.MethodsPlasma samples were collected retrospectively from two propensity score-matched STEMI cohorts from May 6, 2020 to April 20, 2021. Cohort 1 consisted of 48 survivors and 48 non-survivors. Cohort 2 included 48 patients with unstable angina pectoris, 48 patients with STEMI, and 48 age- and sex-matched healthy controls. Metabolic profiling was generated based on ultra-performance liquid chromatography and a mass spectrometry platform. The comprehensive metabolomic data analysis was performed using MetaboAnalyst version 5.0. The hub metabolite biomarkers integrated into the model were tested using multivariate linear support vector machine (SVM) algorithms and a generalized estimating equation (GEE) model. Their predictive capabilities were evaluated using areas under the curve (AUCs) of receiver operating characteristic curves.ResultsMetabonomic analysis from the two cohorts showed that patients with STEMI with different outcomes had significantly different clusters. Seven differentially expressed metabolites were identified as potential candidates for predicting inhospital outcomes based on the two cohorts, and their joint discriminative capabilities were robust using SVM (AUC = 0.998, 95% CI 0.983–1) and the univariate GEE model (AUC = 0.981, 95% CI 0.969–0.994). After integrating another six clinical variants, the predictive performance of the updated model improved further (AUC = 0.99, 95% CI 0.981–0.998).ConclusionA survival prediction model integrating seven metabolites from non-targeted metabonomics and six clinical indicators may generate a powerful early survival prediction model for patients with STEMI. The validation of internal and external cohorts is required.
Impact of Systematic Tailored Assessment for Responding to Suicidality (STARS) Protocol Training on Mental Health Professionals' Attitudes, Perceived Capabilities, Knowledge, and Reluctance to Intervene
Authors: Hawgood Jacinta , Ownsworth Tamara , Kõlves Kairi , Spence Susan H. , Arensman Ella , De Leo Diego 
Published: February 2022

Background and AimsSystematic Tailored Assessment for Responding to Suicidality (STARS) protocol and associated training were developed with the key objectives of supporting clinicians to conduct a suicide enquiry, obtaining a comprehensive account of psycho-social factors contributing to suicidality, and collaboratively developing a safety plan with clients. STARS training aims to address knowledge, attitudes and capabilities that influence intervention behavior/skills. This study aimed to examine associations between clinician characteristics and pre-training competencies in suicide risk assessment (SRA), as well as the impact of STARS training workshop on clinician competencies; and to determine the predictors of SRA training outcomes.MethodAustralian mental health professionals working with suicidal persons who undertook the STARS 2-day face-to-face workshop between 2018 and 2020 completed an online survey at pre- and post-training. Of the 222 participants who completed the pre-training questionnaire, 144 (64.9%) also completed the post-training questionnaire. Participants were mostly female (75.7%), had completed a university degree (86.4%), had &lt;10 years of experience in suicide prevention (71.7%), and were allied and mental health professionals (78.1%). We used linear mixed-effects regression for statistical analyses.ResultsSTARS participants who reported higher perceived capability at baseline had significantly greater formal and informal training, more years of experience in suicide prevention, and were more likely to have experienced client suicide and/or suicide attempt and to report fewer SRA related fears. We found overall significant positive impacts of STARS training on clinician competencies (attitudes, perceived capability, declarative knowledge) from pre- to post-training. The most distinct changes following STARS training were for perceived capability and declarative knowledge. Participants who had more positive attitudes after training were significantly more likely to have had less prior supervision/mentoring. Reluctance to intervene was not found to significantly change after training.ConclusionsWe found evidence that attitudes, perceived capability and declarative knowledge changed positively from pre- to post-STARS training among mental health professionals. Underpinned by the minimum standardized SRA competencies, STARS training may be critical for informing evidence-based knowledge and skills in SRA and safety planning.