bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and Biological Activity of Chemoimmunotherapy in Advanced Endometrial Adenocarcinoma: A Phase II Trial of the Big Ten Cancer Research Consortium
Authors: Barber Emma L. , Chen Siqi , Pineda Mario Javier , Robertson Sharon E. , Hill Emily K. , Teoh Deanna , Schilder Jeanne , O'Shea Kaitlyn L. , Kocherginsky Masha , Zhang Bin , Matei Daniela 
Published: August 2022

Purpose:The objective of this study was to assess the efficacy and safety of pembrolizumab in combination with standard carboplatin/paclitaxel in patients with advanced endometrial cancer.Patients and Methods:This single-arm, open-label, multicenter phase II study enrolled patients with RECIST measurable advanced endometrial cancer. Patients could have received ≤ 1 prior platinum-based regimen and ≤ one non-platinum chemotherapy. The primary endpoint was objective response rate (ORR). Planned sample size of 46 subjects provided 80% power to detect 15% ORR improvement compared with historical control rate of 50%.Results:A total of 46 patients were enrolled and 43 were evaluable for ORR. Median age was 66 (range: 43–86). Thirty-four (73.9%) patients had recurrent and 12 (26.1%) primary metastatic endometrial cancer. Patients received carboplatin AUC6, paclitaxel 175 mg/m2, and pembrolizumab 200 mg i.v. every 3 weeks for up to six cycles. ORR was 74.4% (32/43), higher than historic controls (P = 0.001). Median progression-free survival (PFS) was 10.6 months (95% confidence interval, 8.3–13.9 months). The most common grade 1–2 treatment-related adverse event (TRAE) included anemia (56.5%), alopecia (47.8%), fatigue (47.8%), and neuropathy (13%), while the most common grade 3–4 TRAEs were lymphopenia, leukopenia, and anemia (19.6% each). High-dimensional spectral flow cytometry (CyTEK) identified enrichment in peripheral CD8+ and CD4+ T-cell populations at baseline in responders. The CD8+ T-cell compartment in responders exhibited greater expression levels of PD-1 and PD-L1 and higher abundance of effector memory CD8+ cells compared with nonresponders.Conclusions:Addition of pembrolizumab to carboplatin and paclitaxel for advanced endometrial cancer was tolerated and improved ORR compared with historical outcomes.Significance:The results of the study support that the combination of pembrolizumab with carboplatin and paclitaxel is well tolerated and active in patients with advanced endometrial cancer. The duration of response and the PFS were significantly longer in patients with mismatch repair deficient/microsatellite instability-high compared with mismatch repair proficient/microsatellite stable tumors. Responders to treatment tend to have enriched CD8+ T-cell and CD4+ T-cell populations among peripheral blood mononuclear cells at baseline.
Adriana Menezes - A responsabilidade do Jornalismo Ambiental como agente transformador na cobertura sobre meio ambiente
Authors: Couto Andreia Terzariol 
Published: August 2022

A cobertura ambiental brasileira, de forma geral, tem sido marcada por uma falta de aprofundamento e contextualização sobre os fenômenos que abrangem as grandes questões dessa editoria na atualidade, tais como: agressivo desmatamento e grilagem de terras nos principais biomas brasileiros, a saber, floresta amazônica e Pantanal; avanço da fronteira agrícola em direção a esses espaços geográficos de forma descontrolada, ocupando-os sob a forma de monocultura da soja e pastagens; aquecimento global e mudanças climáticas, em decorrência do aniquilamento dos sistemas de vegetação nativa; cobertura sensacionalista de fenômenos climáticos; contaminação dos recursos hídricos, até mesmo dos grandes sistemas Aquífero Guarani e Sistema Amazônico; falta de formação específica dos profissionais que cobrem a pauta de meio ambiente, com a consequente cobertura não aprofundada dos fatos, entre outros fatores. Para analisar o contexto da cobertura ambiental, entrevistamos a jornalista Adriana Menezes, que toma como exemplo o desastre ambiental ocorrido em Mariana, Minas Gerais, em novembro de 2015.
Prenatal Lipopolysaccharides Exposure Induces Transgenerational Inheritance of Hypertension
Authors: Cao Nian , Lan Cong , Chen Caiyu , Xu Zaicheng , Luo Hao , Zheng Shuo , Gong Xue , Ren Hongmei , Li Zhuxin , Qu Shuang , Yu Cheng , Yang Jining , Jose Pedro A. , Chen Yundai , Wu Gengze , Hu Cuimei , Yu Junyi , Zeng Chunyu 
Published: August 2022

Background:
Adverse environmental exposure during the prenatal period can lead to diseases in the offspring, including hypertension. Whether or not the hypertensive phenotype can be transgenerationally transmitted is not known.

Methods:
Pregnant Sprague Dawley rats were intraperitoneally injected with lipopolysaccharide (LPS) on gestation days 6, 8, 10, and 12 to generate the prenatal LPS exposure model. Blood pressure was monitored by both telemetry and tail-cuff method. RNA sequencing was performed to analyze transcriptome alteration in the kidney of the third generation. Tempol and spironolactone were used to test the potential preventative and therapeutic effect of targeting reactive oxygen species and mineralocorticoid receptor signaling, respectively. Molecular biological experiments were performed to illustrate the mechanism of epigenetic and transcription regulation.

Results:

Prenatal LPS exposure can impair the ability to excrete a salt load and induce hypertension from the first to the third generations, with the fourth and fifth generations, inducing salt-sensitive hypertension. Compared with control pups, the transcriptome in the kidney of the hypertensive third-generation prenatal LPS–exposed offspring have upregulation of the Ras-related C3 botulinum toxin substrate 1 (
Rac1
) gene and activation of mineralocorticoid receptor signaling. Furthermore, we found that LPS exposure during pregnancy triggered oxidative stress that upregulated KDM3B (histone lysine demethylase 3B) in the oocytes of first-generation female rats, leading to an inheritable low level of H3K9me2 (histone H3 lysine 9 dimethylation), resulting in the transgenerational upregulation of
Rac1
. Based on these findings, we treated the LPS-exposed pregnant rats with the reactive oxygen species scavenger, tempol, which successfully prevented hypertension in the first-generation offspring and the transgenerational inheritance of hypertension.

Conclusions:
These findings show that adverse prenatal exposure induces transgenerational hypertension through an epigenetic-regulated mechanism and identify potentially preventive and therapeutic strategies for hypertension.
Integrating Region- and Network-level Contributions to Episodic Recollection Using Multilevel Structural Equation Modeling
Authors: Kurkela Kyle A. , Cooper Rose A. , Ryu Ehri , Ritchey Maureen 
Published: August 2022

Abstract
The brain is composed of networks of interacting brain regions that support higher-order cognition. Among these, a core network of regions has been associated with recollection and other forms of episodic construction. Past research has focused largely on the roles of individual brain regions in recollection or on their mutual engagement as part of an integrated network. However, the relationship between these region- and network-level contributions remains poorly understood. Here, we applied multilevel structural equation modeling to examine the functional organization of the posterior medial (PM) network and its relationship to episodic memory outcomes. We evaluated two aspects of functional heterogeneity in the PM network: first, the organization of individual regions into subnetworks, and second, the presence of regionally specific contributions while accounting for network-level effects. Our results suggest that the PM network is composed of ventral and dorsal subnetworks, with the ventral subnetwork making a unique contribution to recollection, especially to recollection of spatial information, and that memory-related activity in individual regions is well accounted for by these network-level effects. These findings highlight the importance of considering the functions of individual brain regions within the context of their affiliated networks.
Temporal Organization of Episodic and Experience-near Semantic Autobiographical Memories: Neural Correlates and Context-dependent Connectivity
Authors: Teghil Alice , Bonavita Alessia , Procida Federica , Giove Federico , Boccia Maddalena 
Published: August 2022

Abstract
Autobiographical memory includes a representation of personal life events with a unique spatiotemporal context (episodic autobiographical memory) and factual self-knowledge (personal semantics). Whereas “experience-far” personal semantics have undergone complete abstraction, “experience-near” personal semantics are still linked to a spatiotemporal context. The representation of one's own past involves an autobiographical knowledge base, in the form of a personal timeline, along which autobiographical information is temporally organized into different lifetime periods. Commonalities and differences between brain networks supporting this temporal organization for autobiographical information with different contextual specificity, however, have not been investigated to date. Here, we used task-based fMRI to assess neural substrates of temporal ordering along the personal timeline for real autobiographical episodic and experience-near personal semantic memories. Within a distributed network, the left calcarine cortex was more strongly activated for episodic autobiographical memory than personal semantics, whereas the left ventromedial pFC and right posterior cingulate cortex (PCC), angular gyrus (AG), and anterior middle temporal gyrus (aMTG) showed stronger activation for personal semantics than episodic autobiographical memory. Findings were confirmed by analyses in independently derived ROIs. Generalized psychophysiological interaction analyses between the same regions showed that, during personal semantics compared with episodic autobiographical memory, memory category modulated activity in the left PCC and right PCC, AG, and aMTG. Findings provide insights on how personal events and facts are represented in the timescale of years, suggesting that the temporal organization of autobiographical memory exploits properties of situation models developed within posteromedial, lateral parietal, and medial prefrontal regions.
Pentecostalized and Pillarized. Neo-Dhimmitude and the Religious Market in Kuwait
Authors: Crace Benjamin 
Published: August 2022

Abstract
This article uses a qualified religious market model to first describe and then analyze the context and shifts of significant Christian populations in Kuwait. It argues that due to neo-dhimmitude, the religious market is pillarized and maintains that the shift towards pentecostalized Christianity indicates a rise in demand for embodied spirituality and religious narratives that justify the sacrifices and burdens of transnational migration. It concludes that pentecostalized Christianity is a significant element within the pillarized religious market of Kuwait while demonstrating how the religious market model may be adapted for non-Western contexts.
Nederlandsch Zendingsvereeniging’s Efforts to Improve the Position of Women in the Society of West Java
Authors: Sukamto Amos 
Published: August 2022

Abstract
In this article, I argue that Nederlandsch Zendingsvereeniging (NZV) missionaries played an important role in improving the position of women in the society of West Java. Although their main motivation was the spreading of Christianity, they were fully aware of perspectives on the inferior status of women and were concerned to improve the latter’s position. The missionaries aimed to regulate marriage and address the problem of concubinage, establish schools for women, accept women as part of the staff in their offices, provide space for women to vote for and become church councillors, and even dared to allow women to be ministers in at least one congregation when this had been a proscribed subject. But their efforts seemed so exclusively confined to Christian circles, that their influence did not go beyond to the wider community.
Endangered populations of Messor arenarius ants in the Northern Coastal Plain of Israel
Authors: Warburg Ittai 
Published: August 2022

Abstract
Messor arenarius (Fabricius) is a harvester ant species, which is mainly distributed in deserts of the Middle East and North Africa. Ants of this species dig their nests in loess or sandy soils. In Israel, this ants’ species is distributed in the Negev Desert and in sandy soils along the Mediterranean Coastal Plain. In this work, 12 sites of natural habitats in the Northern Coastal Plain of Israel were surveyed for surface activity of M. arenarius ants. These ants were found in 3 out of these 12 natural habitats. Two of these sites where M. arenarius ants were found were subjected to disturbance, caused by development works during the period of this survey. It is concluded, that the populations of M. arenarius in the Northern Mediterranean Coastal Plain of Israel are endangered. It is also concluded, that the presence of either Artemisia monosperma or Retama raetam bushes in certain habitats in the Northern Coastal Plain of Israel, are not necessary or sufficient conditions for presence of M. arenarius in these same habitats.
Paecilomyces clematidis (Eurotiales, Thermoascaceae): a new species from Clematis root
Authors: SPETIK MILAN , BERRAF-TEBBAL AKILA , GRAMAJE DAVID , EDDINE MAHAMEDI ALLA , STUSKOVÁ KATERINA , BURGOVA JANA , EICHMEIER ALES 
Published: August 2022

During a survey of endophytic fungi associated with ornamental plants in the Czech Republic, Paecilomyces-like strains were isolated from the root of Clematis. Analyses based on a combined internal transcribed spacer region (ITS), beta-tubulin (tub2) and calmodulin (CaM) sequence data matrix were applied to infer the phylogenetic position of these isolates. The novel species is characterized by phialides with a cylindrical basal portion tapering to a thin long neck producing pyriform conidia in chains. The new species is introduced with comprehensive descriptions, illustrations and a phylogenetic tree herein. Two primer pairs targeting the partial CaM gene, cm1F/cm1R and cm2F/cm2R, were designed in this study.
The Effects of Attention Deficit Hyperactivity Disorder and Other Psychiatric Comorbidities to Outcomes in Trauma Patients
Authors: Zwemer Catherine H. , Day Margot E. , Zebley James A. , Qaddumi Waleed N. , Li Meng-Hao , Yu Yang , Koizumi Naoru , Kartiko Susan 
Published: August 2022

Background Psychiatric illnesses affect outcomes in trauma. Studies have examined the relationship between depression, schizophrenia, post-traumatic stress disorder, and other mental disorders with trauma, yet few have examined attention-deficit-hyperactivity disorder (ADHD). Attention-deficit-hyperactivity disorder has been suggested to increase the risk of injury, but severity and outcomes of the injury are not frequently studied. The relationship of additional psychiatric disorders in patients with ADHD to traumatic injury was also examined in this study. Methods A 5-year retrospective analysis was performed using the trauma registry of an urban ACS verified level 1 trauma center. Patients with ADHD were separated into ADHD Only and ADHD+ (having additional psychiatric comorbidities) and compared to a matched population of non-ADHD patients and patients with non-ADHD psychiatric disorders to analyze their demographics and outcomes. Descriptive statistics were used to analyze the data as appropriate. Results Seventy-three patients with ADHD were identified, with over half having additional psychiatric comorbidities (58.9%). The majority of ADHD patients were White (54.8%) vs Black (61.6%) at admission. At admission non-ADHD patients had significantly fewer psychiatric comorbidities (11%) compared to ADHD patients (58.9%). ADHD with psychiatric comorbidities patients had significantly higher ISS and longer hospital LOS. However, GCS and ICU LOS were not different between the two groups. Conclusions Patients with ADHD were significantly more likely to have psychiatric comorbidities and experience worse outcomes compared to patients without ADHD.
Rapid initiation of nasal saline irrigation to reduce severity in high-risk COVID+ outpatients
Authors: Baxter Amy L , Schwartz Kyle R , Johnson Ryan W , Kuchinski Ann-Marie , Swartout Kevin M , Srinivasa Rao Arni S R , Gibson Robert W , Cherian Erica , Giller Taylor , Boomer Houlton , Lyon Matthew , Schwartz Richard 
Published: August 2022

Objective To determine whether initiating saline nasal irrigation after COVID-19 diagnosis reduces hospitalization and death in high-risk outpatients compared with observational controls, and if irrigant composition impacts severity. Methods Participants 55 and older were enrolled within 24 hours of a + PCR COVID-19 test between September 24 and December 21, 2020. Among 826 screened, 79 participants were enrolled and randomly assigned to add 2.5 mL povidone-iodine 10% or 2.5 mL sodium bicarbonate to 240 mL of isotonic nasal irrigation twice daily for 14 days. The primary outcome was hospitalization or death from COVID-19 within 28 days of enrollment by daily self-report confirmed with phone calls and hospital records, compared to the CDC Surveillance Dataset covering the same time. Secondary outcomes compared symptom resolution by irrigant additive. Results Seventy-nine high-risk participants were enrolled (mean [SD] age, 64 [8] years; 36 [46%] women; 71% Non-Hispanic White), with mean BMI 30.3. Analyzed by intention-to-treat, by day 28, COVID-19 symptoms resulted in one ED visit and no hospitalizations in 42 irrigating with alkalinization, one hospitalization of 37 in the povidone-iodine group, (1.27%) and no deaths. Of nearly three million CDC cases, 9.47% were known to be hospitalized, with an additional 1.5% mortality in those without hospitalization data. Age, sex, and percentage with pre-existing conditions did not significantly differ by exact binomial test from the CDC dataset, while reported race and hospitalization rate did. The total risk of hospitalization or death (11%) was 8.57 times that of enrolled nasal irrigation participants (SE = 2.74; P = .006). Sixty-two participants completed daily surveys (78%), averaging 1.8 irrigations/day. Eleven reported irrigation-related complaints and four discontinued use. Symptom resolution was more likely for those reporting twice daily irrigation ( X2 = 8.728, P = .0031) regardless of additive. Conclusion SARS-CoV-2+ participants initiating nasal irrigation were over 8 times less likely to be hospitalized than the national rate.
Addressing inequity in palliative care provision for older people living with multimorbidity. Perspectives of community-dwelling older people on their palliative care needs: A scoping review
Authors: Nicholson Caroline Jane , Combes Sarah , Mold Freda , King Helen , Green Richard 
Published: August 2022

Background: Older people living with multimorbidity are projected to become the main recipients of palliative care in the coming decades, yet there is limited evidence regarding their expressed palliative care needs to inform person-centred care. Aim: To understand the palliative care needs of community-dwelling people aged ⩾60 living with multimorbidity in the last 2 years of life. Design: A scoping review following Arksey and O’Malley. Data sources: Three international electronic databases (CINAHL, Ovid Medline, PsycINFO) were searched from March 2018 to December 2021. Reference lists were hand searched. Eligible papers were those reporting empirical data on older people’s needs. Results: From 985 potential papers, 28 studies were included, published between 2002 and 2020; sixteen quantitative, nine qualitative and three mixed methods. Data were extracted and presented under the holistic palliative care domains of need: physical, psychological, social, spiritual, and additionally practical needs. Different measurement tools ( n = 29) were used, of which 20 were multidimensional. Primacy in reporting was given to physical needs, most commonly pain and function. Social and practical needs were often prioritised by older people themselves, including maintaining social connections and accessing and receiving individualised care. Conclusion: Identifying the palliative care needs that matter most to older people with multimorbidity requires the recognition of their concerns, as well as their symptoms, across a continuum of living and dying. Available evidence is superficial. Supporting end of life provision for this growing and underserved population necessitates a shift to tailored multidimensional tools and community focussed integrated care services.
Self-care behavior and associated factors among patients with heart failure in public hospitals of Southeast Ethiopia
Authors: Getachew Almaz , Assefa Tesfaye , Negash Wogene 
Published: August 2022

Objective This study was performed to assess self-care behavior and associated factors among patients with heart failure attending public hospitals in Southeast Ethiopia in 2021. Methods An institutional-based cross-sectional study was conducted among 420 patients with heart failure from 15 May to 30 June 2021 using a simple random sampling technique. A multivariable binary logistic model was used to identify factors associated with self-care behavior. Statistical significance was declared at p < 0.05. Results The magnitude of good self-care behavior among patients with heart failure was 53.6% [95% confidence interval (CI), 48.9–58.3]. Factors associated with self-care behavior were treatment with a beta blocker [adjusted odds ratio (AOR), 0.49; 95% CI, 0.27–0.89], treatment with digitalis (AOR, 0.11; 95% CI, 0.05–0.24), the level of social support (AOR, 0.07; 95% CI, 0.03–0.15), and the presence of depressive symptoms (AOR, 0.21; 95% CI, 2.70–8.33). Conclusion Slightly more than half of the respondents had good self-care behavior. Attention should be given to enhancing good self-care practice through integration of health education as routine care.
Reversible Control of Reproduction In Queens: Mastering the use of reproductive drugs to manipulate cyclicity
Authors: Romagnoli Stefano , Ferre-Dolcet Lluis 
Published: August 2022

Background: The literature is full of papers reporting side effects of progestogens in cats; however, they are, in fact, safe drugs, as discussed in this article. Gonadotropin-releasing hormone (GnRH) agonists and melatonin are additionally a practical solution for controlling cyclicity in queens, but they also have some contraindications and need to be used carefully. Clinical relevance: Mastering the use of reproductive drugs allows feline practitioners to handle many more clinical situations than can be solved using surgery. It is not necessary to be a specialist in reproduction to be able to halt cyclicity in a valuable breeding queen using hormones. Equipment and technical skills: A sound knowledge of appropriate dosages and criteria for patient selection for all reproductive drugs currently used in feline reproduction is the best guarantee of owner satisfaction and of ensuring the queen’s health. Availability of a serum progesterone assay, either in-house or via an external laboratory, is also important, in order to confirm a queen is at an appropriate stage of the reproductive cycle for treatment. Audience: This article is aimed principally (but not exclusively) at veterinarians working with cat breeders and whose clientele is increasingly interested in alternative methods of controlling reproduction in pet queens. Surgery is no longer the only choice, and practitioners who manage to keep abreast of new developments will be able to address clients’ needs in a modern, professional way. Evidence base: This review draws on a vast body of scientific evidence-based literature. Previously, personal (and sometimes misinformed) opinions, such as the proposed dangerous side effects of progestogens, have been perpetuated in the scientific literature. The papers cited in this review have therefore been carefully scrutinised to distinguish reliable information based on controlled studies from non-evidence-based information.