bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overlooking the front line: Impacts of front‐line worker inclusion on implementation and outcomes of collaborative innovation
Authors: Livingstone Riley V. 
Published: February 2022

AbstractPolicymakers acknowledge the need to drive innovation in health and social care, given the complex, “wicked” problems that such services are tasked with solving and the concept of collaborative innovation is proposed as a tool in which to reach solutions to these problems. Prior case studies have overlooked the element of front‐line worker inclusion on processes of collaborative innovation. This research explores this element through a case study of an intermediate care facility in Scotland. This collaboration produced innovation, but the strength of the innovative solution was diluted by the omission of front‐line workers in key phases of the innovation process. This paper contributes to the broader public administration literature by operationalizing a novel conceptual framework of collaborative innovation and by exploring the problematic implications of neglecting to include front line worker perspectives throughout the process of collaborative innovation.
The Modern‐Day Cicero: An Alternative Interpretation of the Work of Ronald Dworkin
Authors: Dyevre Arthur , Wijtvliet Wessel 
Published: February 2022

AbstractRonald Dworkin is one of the most frequently cited legal philosophers. His work, notably his attack on H. L. A. Hart's positivist theory of law, has received considerable attention, earning him praise as well as trenchant criticism. Instead of discussing the analytical validity of Dworkin's claims, though, we propose an alternative reading of his jurisprudential writings that emphasises their rhetorical nature. After delineating the rhetorical context of his work, we provide several illustrations of his use of rhetorical strategies and, with the help of sentiment‐analysis techniques, emotional language. While resorting to classical rhetorical tactics, Dworkin's rhetoric, we argue, appealed to the emotional power of rights talk at a time when the notion of rights enjoyed greater resonance with his audience.
Comparison of GnRH and hCG effects on oestradiol, progesterone and premature luteolysis in Ovsynch‐synchronized ewes
Authors: Salloum Abir , Saleh Mohammed 
Published: February 2022

AbstractThe purpose of this study was to ascertain whether premature luteolysis can be alleviated by substituting the ovulation inducing agent hCG for GnRH. Seventy‐two hours after the end of artificial insemination (AI), pluriparous Awassi ewes were randomly assigned to one of three treatment groups of 13 ewes each. First group received 37.5 µg of the GnRH analog Lecirelin, the second 1000 I.U hCG and the third group served as a control (received 1 ml of physiological saline solution). Blood samples were collected at daily intervals after GnRH treatment and analysed for plasma oestradiol and progesterone concentrations. Ovarian follicles were monitored ultrasonically at the time of GnRH administration, 60 hr and 84 hr later. Pregnancy was diagnosed ultrasonically at Day 35 after AI. Number and size of ovarian follicles did not differ (p > .05) among treatment groups. Onset and duration of oestrus were not affected by treatment (p > .05). No significant differences (p > .05) were recorded in oestradiol and progesterone concentrations between the treatment groups during the inspection period. Premature luteolysis became evident in ewes with longer oestrous durations by Day 6.25 after AI and amounted to 7.69%, 18.18% and 23.07% in GnRH, hCG and Control groups respectively. Pregnancy rates increased to 92.31% and 81.82% in GnRH and hCG groups, compared to 76.92% in the Control group. The results indicate that GnRH was more effective in reducing premature luteolysis than hCG. Substituting hCG for GnRH as an ovulation inducing agent was of no avail.
The Island Is Still There: Experimental Evidence For The Inescapability Of Relative Clauses In English*
Authors: Christensen Ken Ramshøj , Nyvad Anne Mette 
Published: February 2022

AbstractIt is standardly assumed that relative clauses are islands for extraction in English, and that constraints on extraction from syntactic islands are universal. However, it has been shown that the Mainland Scandinavian languages provide a large variety of counterexamples. This study investigates the island status of English relative clauses in the light of these counterexamples. 190 native speakers provided acceptability judgments on a 5‐point Likert scale of 48 target sentences. The results show that, unlike in Danish, acceptability of extraction is not correlated with frequency of occurrence of the matrix verb or with exposure over time. Furthermore, there is no difference in acceptability between moving a topic or a wh‐element out of a relative clause. We argue that this supports the traditional analysis of English relative clauses as strong islands, and that the results are compatible with a parametric account of language variation.
Impact of Integration of the Production Systems and Reservoir of a Benchmark Based on Carbonate Fields
Authors: Victorino I. R. S. , Hohendorff Filho J. C. V. , Castro M. S. , Schiozer D. J. 
Published: February 2022

AbstractIntegrating production system and reservoir is used in several studies of offshore oilfield development and management for improved production forecasts through more realistic boundary conditions. This study evaluates the influence of the parameters in a production strategy of a reference model (carbonate oil reservoir) on financial and production performance. We first considered nonintegrated system (NI) with the reservoir and fixed boundary conditions for well and gathering system. We then considered integrated system (I) with the variable boundary conditions for the wells and gathering system. Finally, we compared both systems. Our analysis involved several steps to define the best production strategy for both systems based on net present value (NPV) and how integrated modeling helps define production strategy. For NI, three stages were considered: number of wells, placement of wells, and platform capacity. For I, five stages were evaluated (all NI parameters) with diameters and gas lift evaluation, and platform placement. The results are similar, but the simplifications (NI) may affect financial performance. The cross analysis indicated (in the hypothesis that the integrated system is closer to reality) that integrating the NI case resulted in considerable financial and production differences and may be useful in simplified systems. Since the main aspects of the object-function financial return were related to reservoir model behavior, one can first apply the nonintegrated optimization cycles, then add the integrated cycles, obtaining an intermediate time of the integrated model optimization in similar cases.
A peralkaline solution, hydrofracturing model for quartzofeldspathic veins and pegmatites
Authors: Wintsch R.P. , Resor P. 
Published: February 2022

ABSTRACT
We present a tectonic model for the generation of quartzofeldspathic veins and pegmatite dikes found in southern New England that proposes the following: (1) Hydraulic fracturing produces the initial fracture that opens to become a vein, and (2) oscillating differential stress produces a gradient in interstitial fluid pressure that draws the melt to the dilating walls of the fracture. Oscillating fluid pressures at the dike walls lead to oscillating rates of crystallization, and thus to alternating aplitic and pegmatitic textures in dikes as thin as a few centimeters. Excess alkalis and SiO2(aq) lower the solidus temperature of the granitic liquid and thus stabilize a peralkaline silicate liquid without crystallization. This silicate liquid is capable of crystallizing only quartz, only feldspars, or both. Crystallization of this liquid lowers its pH and accounts for the mineralogical zoning consisting of quartz cores, feldspathic mantles, and muscovite-bearing margins common in many quartzofeldspathic veins.
The Cenozoic evolution of the Intrarif (Rif, Morocco)
Authors: Martín-Martín Manuel , Guerrera Francesco , Maaté Alí , Hlila Rachid , Serrano Francisco , Cañaveras Juan C. , Paton Douglas , Alcalá Francisco J. , Maaté Soufian , Tramontana Mario , Martín-Pérez José A. 
Published: February 2022

AbstractThis paper provides an understanding of the sedimentary-tectonic evolution of the Cenozoic strata of the El Habt and Ouezzane Tectonic Units (Intrarif, External Rif) in Morocco. New data provide information about the depositional architecture and enable a correlation of the evolution of the External Rif in Morocco with that of the Betic Cordillera in Spain and the Tunisian Tell, which provides new insights for hydrocarbon exploration in the region regarding possible source, reservoir, and seal rocks. The reconstructed Cenozoic succession was bio-chronologically defined, and the major unconformities and stratigraphic gaps were identified. The presence of these unconformities allowed three main stratigraphic sequences to be defined by age: Danian p.p., early Ypresian–early Bartonian p.p., and the early Rupelian–early Serravallian p.p. Three secondary stratigraphic sequences in the former upper main sequence were also defined by age: early Rupelian–late Chattian p.p., Burdigalianp.p., and the Langhian–Serravallian p.p. The depositional setting evolved from deep basin during the Late Cretaceous–Paleocene to external platform-slope during the Eocene–Miocene. The Cenozoic sandstones contain metamorphic and sedimentary rock fragments derived from a recycled orogen source area. The clay mineralogy in the Cenozoic strata consists of associations of Ill+(I–S) ± Sme, Ill+(I–S) ± Sme+Kln and Ill+(I–S) ± Sme+Kln+Chl. These associations indicate an initial unroofing in the Paleogene period, then in the Cretaceous period, and finally in the Late Jurassic period during the Eocene–Oligocene. This detritus was followed by variable amounts of a sedimentary mix of Paleogene to Late Jurassic terrains due to several phases of erosion and deposition partly related to syn-sedimentary tectonics during the Miocene. Equivalent features (similar types of sediments, tectofacies, gaps, and unroofing) were also recognized along the Betic Cordillera in Spain and Maghrebian Chain (Morocco and Tunisia) and interpreted as related to a pre-nappe tectonic activity of soft basement folding, which occurred during the Paleogene after the generalized tectonic inversion (from extension to compression) occurred in the Late Cretaceous. The Upper Cretaceous is considered to be the hydrocarbon source rock, while the fractured Eocene and the porous Oligo-Miocene suites are proposed as possible hydrocarbon reservoirs. The Cenozoic stratigraphic architecture and the nappe structure of the region could provide the necessary trap structures.
Neogene sedimentary record of the evolution of a translated strike-slip basin along the Denali fault system: Implications for timing of displacement, composite basin development, and regional tectonics of southern Alaska
Authors: Allen Wai K. , Ridgway Kenneth D. , Benowitz J.A. , Waldien T.S. , Roeske S.M. , Fitzgerald P.G. , Gillis R.J. 
Published: February 2022

AbstractAnalysis of the late Miocene to Holocene McCallum sedimentary basin, located along the south side of the eastern Denali fault system, provides a better understanding of strike-slip basin evolution, timing of displacement on the Denali fault, and tectonics of the southern Alaska convergent margin. Analysis of the McCallum basin utilizing measured stratigraphic sections, lithofacies analyses, and 40Ar/39Ar tephra ages documented a 564-m-thick, two-member stratigraphy. Fine-grained, lacustrine-dominated environments characterized deposition of the lower member, and coarse-grained, stream-dominated alluvial-fan environments characterized deposition of the upper member. The 40Ar/39Ar dating of tephras indicated that the lower member was deposited from 6.1 to 5.0 Ma, and the upper member was deposited from 5.0 to 3.8 Ma. Our stratigraphic analysis of the McCallum basin illuminates the development of a composite strike-slip basin, with the deposition of the lower member occurring along a transtensional fault section, and deposition of the upper member occurring along a transpressional fault section. This change in depositional and tectonic settings is interpreted to reflect ~79–90 km of transport of the basin along the Denali fault system based on Pleistocene–Holocene slip rates. Previous studies of the timing of Cenozoic displacement on the Denali fault system utilizing sedimentary records emphasized a Paleogene component; our findings, however, also require a significant Neogene component. Neogene strike-slip displacement and basin development along the Denali fault system were broadly coeval with development of high topography and related clastic wedges across southern Alaska in response to flat slab subduction of the Yakutat microplate.
Latest Triassic–Early Jurassic Stikine–Yukon-Tanana terrane collision and the onset of accretion in the Canadian Cordillera: Insights from Hazelton Group detrital zircon provenance and arc–back-arc configuration
Authors: Nelson JoAnne L. , van Straaten Bram , Friedman Richard 
Published: February 2022

AbstractThe Hazelton Group is a Rhaetian–Bajocian (uppermost Triassic–Middle Jurassic) volcano-sedimentary sequence that represents both the last pre-accretionary arc volcanic cycle of Stikinia and its early synaccretionary aftermath. Hazelton magmatism of central Stikinia succeeded the Late Triassic (mainly Carnian–Norian) Stuhini arc, which ceased activity as a result of end-on collision with the pericratonic Yukon-Tanana terrane. The Hazelton volcanic belt lies to the south along strike with the coeval Whitehorse trough, the synorogenic clastic basin that developed on top of the Stikinia–Yukon-Tanana collision zone. Whereas the sources of voluminous clastic sediments in the Whitehorse trough were its rapidly exhuming shoulders, the thin clastic intervals in the Hazelton Group in northwestern British Columbia were derived from local to subregional block uplifts that supplied mainly ca. 230–215 Ma zircons eroded from the plutonic roots of the Stuhini arc. Lesser components include late Paleozoic (ca. 350–330 Ma) zircons from Stikinia's basement and penecontemporaneous (ca. 205–172 Ma) zircons from Hazelton volcanic/subvolcanic sources. Reexamination of the four main volcanic fields that make up the lower Hazelton Group suggests that the main Hazelton volcanic belt formed a southward-convex magmatic arc from eastern Stikinia across the Skeena arch, including the Toodoggone and Telkwa belts, with the Spatsizi and Stewart-Iskut regions of northwestern British Columbia in its back-arc. The Whitehorse trough and Hazelton belt represent a collision zone to active arc pair. Southward advance of the arc and counterclockwise rotation of the Stikinia microplate contributed to closure against the Quesnellia arc and assembly of the inner Canadian Cordilleran terrane collage.
Population pharmacokinetics and pharmacodynamics of investigational
regimens’ drugs in the TB-PRACTECAL clinical trial (the PRACTECAL-PKPD
study): a prospective nested study protocol in a randomised controlled
trial
Authors: Nyang'wa Bern-Thomas , Kloprogge Frank , Moore David A.J. , Bustinduy Amaya , Motta Ilaria , Berry Catherine , Davies Geraint R 
Published: February 2022

Introduction
Drug-resistant tuberculosis (TB) remains a global health threat,
with little over 50% of patients successfully treated. Novel regimens
like the ones being studied in the TB-PRACTECAL trial are urgently
needed. Understanding anti-TB drug exposures could explain the success
or failure of these trial regimens. We aim to study the relationship
between the patients’ exposure to anti-TB drugs in TB-PRACTECAL
investigational regimens and their treatment outcomes.

Methods and analysis
Adults with multidrug-resistant TB randomised to investigational
regimens in TB-PRACTECAL will be recruited to a nested
pharmacokinetic-pharmacodynamic (PKPD) study. Venous blood samples will
be collected at 0, 2 and 23 hours postdose on day 1 and 0, 6.5 and 23
hours postdose during week 8 to quantify drug concentrations in plasma.
Trough samples will be collected during week 12, 16, 20 and 24 visits.
Opportunistic samples will be collected during weeks 32 and 72. Drug
concentrations will be quantified using liquid chromatography-tandem
mass spectrometry. Sputum samples will be collected at baseline, monthly
to week 24 and then every 2 months to week 108 for MICs and bacillary
load quantification. Full blood count, urea and electrolytes, liver
function tests, lipase, ECGs and ophthalmology examinations will be
conducted at least monthly during treatment.
PK and PKPD models will be developed for each drug with nonlinear
mixed effects methods. Optimal dosing will be investigated using
Monte-Carlo simulations.

Ethics and dissemination
The study has been approved by the Médecins sans Frontières (MSF)
Ethics Review Board, the LSHTM Ethics Committee, the Belarus RSPCPT
ethics committee and PharmaEthics and the University of Witwatersrand
Human Research ethics committee in South Africa. Written informed
consent will be obtained from all participants. The study results will
be shared with public health authorities, presented at scientific
conferences and published in a peer-reviewed journal.

Trial registration number
NCT04081077;
Pre-results.
Technologies supporting vision screening: a protocol for a scoping
review
Authors: Ali Qasim , Heldal Ilona , Helgesen Carsten Gunnar , Krumina Gunta , Tvedt Marianne Nesbjørg 
Published: February 2022

Introduction
Vision problems affect academic performance, social and mental
health. Most traditional vision screening methods rely on human expert
assessments based on a set of vision tests. As technology advances, new
instruments and computerised tools are available for complementing
vision screening. The scoping review based on this protocol aims to
investigate current technologies for vision screening, what vision tests
can be complemented by technologies, and how these can support vision
screening by providing measurements.

Methods and analysis
The planned review will utilise the PRISMA extension for Scoping
Reviews (PRISMA-ScR) tool. Electronic search will be performed in
databases, including Web of Science, MEDLINE (Ovid), Scopus, Engineering
Village, Cochrane and Embase. We will perform a systematic search in
selected reference databases without the limitation on publications
dates, or country of studies. Reference management software, like
EndNote and DistillerSR, will be used to remove duplicate entries. Two
authors will independently analyse the studies for inclusion
eligibility. Conflicts will be resolved by discussion. We will extract
the types of technologies, types of vision tests they complement and the
measurements for the included studies. Overall findings will be
synthesised by thematic analysis and mapping to the logic
model.

Ethics and dissemination
Ethical approval is not required for this review, as it will only
summarise existing published data. We will publish the findings in an
open access, peer-reviewed journal. We expect that the review results
will be useful for vision screening experts, developers, researchers,
and policymakers.
At the frontlines of digitisation: a qualitative study on the challenges and opportunities in maintaining accurate, complete and timely digital health records in India’s government health system
Authors: Scott Kerry , Ummer Osama , Chamberlain Sara , Sharma Manjula , Gharai Dipanwita , Mishra Bibha , Choudhury Namrata , Mohan Diwakar , LeFevre Amnesty Elizabeth 
Published: February 2022

ObjectivesTo understand factors underpinning the accuracy and timeliness of mobile phone numbers and other health information captured in India’s government registry for pregnant and postpartum women. Accurate and timely registration of mobile phone numbers is necessary for beneficiaries to receive mobile health services.SettingMadhya Pradesh and Rajasthan states in India at the community, clinical, and administrative levels of the health system.ParticipantsInterviews (n=59) with frontline health workers (FLHWs), data entry operators, and higher level officials. Focus group discussions (n=12) with pregnant women to discuss experiences with sharing data in the health system. Observations (n=9) of the process of digitization and of interactions between stakeholders for data collection.Primary and secondary outcome measuresThematic analysis identified how key actors experienced the data collection and digitisation process, reasons for late or inaccurate data, and mechanisms that can bolster timeliness and accuracy.ResultsPregnant women were comfortable sharing mobile numbers with health workers, but many were unaware that their data moved beyond their FLHW. FLHWs valued knowing up-to-date beneficiary mobile numbers, but felt little incentive to ensure accuracy in the digital record system. Delays in registering pregnant women in the online portal were attributed to slow movement of paper records into the digital system and difficulties in gathering required documents from beneficiaries. Data, including women’s phone numbers, were handwritten and copied multiple times by beneficiaries and health workers with variable literacy. Supervision tended to focus on completeness rather than accuracy. Health system actors noted challenges with the digital system but valued the broader project of digitisation.ConclusionsIncreased focus on training, supportive supervision, and user-friendly data processes that prioritise accuracy and timeliness should be considered. These inputs can build on existing positive patient–provider relationships and health system actors’ enthusiasm for digitisation.
Protocol for black student well-being study: a multi-site qualitative study on the mental health and well-being experiences of black UK university students
Authors: Stoll Nkasi , Yalipende Yannick , Arday Jason , Smithies Dominic , Byrom Nicola C. , Lempp Heidi , Hatch Stephani L. 
Published: February 2022

IntroductionThere is an increasing concern about the mental health and mental well-being of university students in the UK. Black university students who report a mental health condition are less likely to complete their course, achieve a first-class or upper second-class degree and progress to further education. This study will document black university students’ accounts of their mental health experiences and perceptions of key turning points of biographical changes to their mental health as they move through the university life cycle.Methods and analysisThis is a qualitative study. Data will be collected through a biographical narrative interpretive method. Interviews will enable the researcher to study systematically how participants make sense of themselves and account for the complexities of their life experiences, from their own perspectives and language. An interpretative phenomenological approach will be used to offer insights into what black students studying at UK universities report affects their mental health and well-being. Data collection for this study commenced in October 2020. Data collection and analyses will be completed by January 2022.Ethics and disseminationFull ethical approval for the current study was obtained from King’s College London Psychiatry, Nursing and Midwifery Research Ethics Subcommittee (Rec Ref: 20489, Project Ref: HR-19/20-20489, 2 October 2020). From the study findings, we aim to contribute to the evidence base, make recommendations for interventions and encourage further study into black student mental health.