bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of the 7R allele on the DRD4 risk tolerance locus is independent of background risk in Senegalese fishermen
Authors: Clochard Gwen-Jiro , Mbengue Aby , Mettling Clément , Diouf Birane , Faurie Charlotte , Sene Omar , Chancerel Emilie , Guichoux Erwan , Hollard Guillaume , Raymond Michel , Willinger Marc 
Published: September 2022

Abstract
It has been shown that living in risky environments, as well as having a risky occupation, can moderate risk-tolerance. Despite the involvement of dopamine in the expectation of reward described by neurobiologists, a GWAS study was not able to demonstrate a genetic contribution of genes involved in the dopaminergic pathway in risk attitudes and gene candidate studies gave contrasting results. We test the possibility that a genetic effect of the DRD4-7R allele in risk-taking behavior could be modulated by environmental factors. We show that the increase in risk-tolerance due to the 7R allele is independent of the environmental risk in two populations in Northern Senegal, one of which is exposed to a very high risk due to dangerous fishing.
Total Knee Arthroplasty and Bariatric Surgery: Change in BMI and Risk of Revision Depending on Sequence of Surgery
Authors: Arani Perna Ighani , Wretenberg Per , Stenberg Erik , Ottosson Johan , W-Dahl Annette 
Published: September 2022

Abstract
Background
Patients with obesity have higher risk of complications after total knee arthroplasty (TKA). We investigated the weight change at one and two years after Bariatric Surgery (BS) in patients that had both TKA and BS and the risk of revision after TKA depending on if BS was performed before or after the TKA.
Methods
Patients having BS within two years before or after TKA were identified from the Scandinavian Obesity Surgery Register (SOReg) and the Swedish Knee Arthroplasty Register (SKAR) between 2007 and 2019 and 2009 and 2020 respectively. The cohort was divided into two groups; patients with TKA before BS (TKA-BS) and patients with BS before TKA (BS-TKA). Multilinear regression analysis and Cox proportional hazards model were used to analyze weight change after BS and the risk of revision after TKA respectively.
Results
Of the 584 patients included in the study, 119 patients had TKA before BS and 465 had BS before TKA. We found no association between the sequence of surgery and total weight loss at one and two years after BS (risk ratio − 0.1 (95% confidence interval (CI) -1.7 to 1.5) and − 1.2 (CI -5.2 to 2.9 respectively), and the risk of revision after TKA (hazard ratio 1.54 (CI 0.5–4.5).
Conclusion
The sequence of surgery in patients undergoing both BS and TKA seems not to have any association with the weight loss after BS or the risk of revision after TKA.
Effect on Growth Performance, Carcass Traits and Myostatin Gene Expression in Aseel Chicken Fed Varied Levels of Dietary Protein in Isocaloric Energy Diets
Authors: Varadharajan Kumaravel , Mohan B. , Natarajan A. , Murali N. , Selvaraj P. , Vasanthakumar P. 
Published: September 2022

Abstract
A study was conducted to assess the effect of feeding different crude protein (CP) levels with isocaloric metabolizable energy (ME) diets on growth performance, carcass traits and myostatin (MSTN) gene expression of Aseel chicken during 0 to 16 weeks of age. A total of two hundred and ten numbers of day-old Aseel chickens were randomly allotted to seven dietary treatment groups. Each group had thirty chicks distributed into three replicates of ten chicks in each. Experimental diets were formulated to have varying levels of CP viz. 18.5, 19.0, 19.5, 20.0, 20.5, 21.0 and 21.5% with isocaloric energy of 2800 kcal ME / kg diets of mash feed were fed to birds in a completely randomised design. Different CP levels had a significant effect (P < 0.05) on body weight gain (BWG) of Aseel chicken. At the end of 16 weeks of age, the group fed 21% CP gained 223.53 g more than the lowest CP 18.5% fed group. The different CP levels did not significantly (P > 0.05) influence the feed intake of all treatment groups, but numerically highest feed intake was observed in the lowest CP (18.5%) fed group. However, significant differences in feed efficiency (FE) appeared from 13th week only with 21.0% CP fed group showing the best FE till 16th week (3.86 to 4.06). The maximum dressing % (70.61) was observed by 21% CP fed group. The CP 21% diet down-regulated the MSTN gene expression in breast muscle tissue to 0.07 folds when compared to the diet of CP 20%. The best economical coordinates for maximum performance for Aseel chicken appeared to be CP of 21% and ME of 2800 kcal/kg to achieve the best FE of 3.86 at the earliest age of 13 weeks. In conclusion, 21% CP in an isocaloric diet of 2800 kcal ME/kg, in Aseel chickens, would be optimum to improve the growth performance at maximum in terms of BWG and FE up to 16 weeks of age.
Sensory Analysis of Formulations Containing Whey Protein to Individuals Undergoing Bariatric Surgery
Authors: ALVAREZ TATIANA , VON ATZINGEN Maria Carolina Batista Campos , Sarni Roseli Saccardo 
Published: September 2022

Abstract
Background: Individuals undergoing bariatric surgery often have inadequate protein intake, which can cause loss of lean body mass and sarcopenia. The whey protein supplement is the most suitable in this situation, however there is a low adherence to long-term use due to the palatability and monotony of the recipes. The aim this study was to analyze the acceptability of recipes containing whey-based protein supplements in individuals undergoing bariatric and metabolic surgery.
Methods: An on-demand sampling was performed, through a prospective, experimental study, with individuals undergoing bariatric surgery, treated by a multidisciplinary team, in a clinic located in São Paulo, Brazil. The study excluded: individuals with possible changes in taste during the sensory testing period. The study was divided into selection of recipes containing whey proteins, recruitment of tasters, sensory and chemical analysis of the recipes.
Results: The sample consisted of 40 tasters, adults, and elderly, who underwent bariatric and metabolic surgery, with a median of eight years of surgery, who had previously consumed a supplement. These individuals were subjected to sensory analysis of six recipes with fresh and minimally processed foods, plus protein supplement. All recipes had food acceptance above 78% and the chemical analysis of the recipes showed an average of 13 grams of protein per serving.
Conclusion: There was favorable acceptance of recipes with whey proteins, which places them as good dietary alternatives for the prevention of sarcopenia and weight relapse in individuals undergoing bariatric and metabolic surgery.
Risk Factors of Childhood Cancer in Armenia: A Case-Control Study
Authors: Avagyan Manushak , Demirchyan Anahit , Abrahamyan Lusine 
Published: September 2022

Abstract
Introduction: Childhood cancer (CC) is a leading cause of death among children aged 0–19 years worldwide. Each year, 400,000 new cases of CC are diagnosed globally. Given the between-country differences in CC incidence rates, types and trends, this study aimed to identify possible risk factors for CC in Armenia. Methods: We used a case-control study design and enrolled participants from the only specialized pediatric hematology and oncology center in Armenia. Cases included patients ≤ 14 years old diagnosed and treated with a malignant disease between 2017–2020 in the centre. Controls included patients diagnosed and treated in the center during the same period for a non-malignant disease. We conducted telephone interviews with mothers of cases and controls. Independent risk factors of cancer were identified using multivariable logistic regression analysis. Results: Overall, 234 participants (117 cases, 117 controls) were included in the study. Based on the fitted model, maternal usage of folic acid during pregnancy was protective against CC, almost twice decreasing its odds (OR = 0.54; 95% CI: 0.31–0.94). On the contrary, experiencing horrifying/terrifying event(s) during pregnancy (OR = 2.19; 95% CI: 1.18–4.07) and having induced abortions before getting pregnant with the given child (OR = 2.94; 95% CI: 1.45–5.96) were associated with higher odds for a child to develop cancer. Conclusion: Despite the limited sample size of the study, significant modifiable risk factors for CC in Armenia were identified, all of which were linked to the period of pregnancy. The data from this study adds to the limited information available in etiological CC research throughout the world, and it will increase understanding of CC risk factors in settings with small populations and low resources.
Caregivers Perception and Management of Common Neonatal Illnesses in Enugu State, Nigeria: A Qualitative study among rural dwellers
Authors: Chime Onyinye H , Eneh Chizoma . I. , Asinobi Isaac N , Ekwochi Uchenna , Ndu Ikenna Kingsley , Nduagubam Obinna C , Amadi Ogechukwu F , Osuorah Donatus Chidiebere 
Published: September 2022

Abstract
Background: Neonatal mortality continues to be a challenge in Nigeria where low-quality care, care-givers ignorance of signs of neonatal illnesses and prevalent use of unorthodox alternatives to health care predominate. Misconceptions originating and propagated as traditional practices and concepts can be linked to adverse neonatal outcomes and an increase in neonatal mortality. Some of these beliefs if not properly identified can be a dogma to any scientific medical intervention.
Methods: This was a cross-sectional qualitative study among female care-givers of children residing in rural communities in Enugu state. A total of six focus group discussions (FGD) were conducted; three in each of the communities using an FGD guide. The guide was developed by the researchers. Thematic analysis was used to analyze the data. Three themes emerged; common signs and symptoms of neonatal illnesses, perception of neonatal illnesses and management of neonatal illnesses.
Results: The mean age of respondents was 36.7±12.7 years. Neonatal illnesses were reportedly presented in two forms; mild and severe forms. Most common features of the mild illnesses reported were fever and crying excessively, refusal of feeds, jaundice, weakness, vomiting and frequent passage of loose stools as well as. The severe ones were breathlessness/difficult or fast breathing, convulsion and draining of pus from the umbilicus. The caregivers’ perception of management varied. It ranged from the use of local remedies to the use of orthodox medications. While some were of the opinion that these illnesses could be managed with unorthodox treatments, others perceived the need to visit the health centres for medical care.
Conclusions: Misconceptions originating and propagated as traditional practices and concepts is associated with adverse neonatal outcomes and an increase in neonatal mortality. Recognizing the signs and symptoms of neonatal illnesses and early treatment is important to help reduce the severity of illness and prevent deaths. Appropriate interventions involving the use of evidence-based newborn care practices should be designed to dispel the myths and improve the knowledge of these caregivers on neonatal illnesses for early and prompt treatment.
Lighting programs at growing phase and their effects on performance and egg quality of meat quails at laying reared in equatorial region
Authors: Watanabe Germana Costa Aguiar , Melo Marcelle Craveiro Abreu , Santos Edibergue Oliveira , Cordeiro Carla Nagila , Nepomuceno Rafael Carlos , Watanabe Pedro Henrique , Freitas Ednardo Rodrigues 
Published: September 2022

Abstract
When applied at growing phase, lighting program aims to obtain quails with body weight and physiological maturity suitable for the beginning of laying. This study evaluates lighting programs at growing phase on performance, sexual maturity and egg quality of meat quails (Coturnix coturnix) at laying phase. During the period from 7 to 49 days of age, 300 female meat quails were subjected to three lighting programs (natural, intermittent and continuous), with 5 replicates of 20 birds each. At 49 days of age, 240 quails were transferred to a shed, maintaining the same experimental distribution and submitted to the same conditions. Continuous and intermittent lighting programs at growing resulted in more precocious quails when compared to natural lighting program. Quails submitted to natural lighting program at growing phase presented lower egg production during all periods, not differing for birds submitted to continuous and intermittent programs from the second period (71 to 92 days of age). It is concluded that in equatorial region, the natural lighting program at growing phase increases the age of sexual maturity and impairs the performance of meat quails at laying; in turn, the intermittent lighting program maintains the sexual maturity, performance and quality of eggs at laying phase.
Intracranial cysts: Incidental or neurodevelopmental?
Authors: Dirik Mehmet Alp , Sanlidag Burcin 
Published: September 2022

Abstract
Objectives:
Intracranial cysts are fluid-filled sacs within the brain. There is a diversity of intracranial cysts with different incidences in addition to the growing awareness about comorbidities and the consequences. The present study aimed to evaluate cystic findings in children who were admitted to the department of pediatric neurology.
Methods:
Children who were admitted to the Clinic of Pediatric Neurology and who had an MRI between 2016- 2021 evaluated. The MRI examination performed with pediatric epilepsy protocol. Primary intracranial cysts had been enrolled in the study. Demographic and clinical findings had been evaluated from the hospital's database and patients' files
Results:
Among 78 patients 36(46,2%) were male and 42(53,8%) were female. The mean age was 7±5,4 years. The most frequent complaint of attendance was a seizure (47,4%). Approximately one over four () had mental and/or motor retardation. Nine (11,5%) of them had a neuropsychiatric diagnosis.
Most of the cysts were located at the midline (41%). Mostly located extra-axial (71,8%) and supratentorial (78,2%). Most frequently arachnoid cysts had been observed with a percent of 64.1. The second leading type was pineal cysts(15.4%).
The history of seizure, epilepsy, presence of mental retardation, and neuropsychiatric problems was evaluated according to the population ratios based on z approximation in which signififantly higher rates had been observed among cases with intracranial cysts.
Conclusion:
Intracranial cysts should be taken into consideration for comorbid pathologies especially in childhood period. Early evaluation in patents with intracranial cysts for developmental delay and neuropsychiatric problems is important.
Differential Algebra Methods Applied to Continuous Abacus Generation and Bifurcation Detection: Application to Periodic Families of the Earth-Moon system.
Authors: Caleb Thomas , Losacco Matteo , Fossà Alberto , Armellin Roberto , Lizy-Destrez Stéphanie 
Published: September 2022

Abstract
The return of human space missions to the Moon puts the Earth-Moon system (EMS) at the center of attention. Hence, studying the periodic solutions to the circular restricted three-body problem (CR3BP) is crucial to ease transfer computations, find new solutions, or to better understand these orbits. This work proposes a novel continuation method of periodic families using differential algebra (DA) mapping. We exploit DA with automatic control of the truncation error to represent each family of periodic orbits as a set 2D Taylor polynomial maps. These maps guarantee the access to any point of the family without any numerical propagation, providing a continuous abacus. When applied to the halo family at L1 and L2, the planar Lyapunov at L1 and L2, the distant retrograde orbit (DRO) family, and the butterfly family, we show that the DA-based 2D mapping is asymptotically more efficient than point-wise methods by at least two orders of magnitude, with controlled accuracy.
To assist the computation of family of periodic orbits, we propose a novel DA-based automatic bifurcation detection algorithm that enables the continuous mapping of the family’s bifurcation criteria. A bifurcation study on the halo L2 shows identical results as point-wise methods while highlighting two undocumented families.
Demographic Dividend-Favorable Policy Environment in Two Pre-Dividend African Nations: Review of National Policies and Prospects for Policy Amendments in Nigeria and Tanzania
Authors: Chen Xiaomeng , Menezes Neia Prata , Rusatira Jean Christophe , Cardona Carolina , Odeku Mojisola , Kioko Deanna , Castro Jessica , Ibeawuchi Charity , Lincoln Joel Silas , Ng'wanansabi Deo , Macha Jacob , Msemo Abubakar , Yusuph Nazir , Rimon Jose G. 
Published: September 2022

Abstract
Background: In collaboration with local partners, we reviewed 18 national policy documents across two sub-Saharan African countries identified as pre-dividend nations by the World Bank in 2017: Nigeria and Tanzania. Our aim was to assess national policies in pre-dividend countries and to determine whether national strategies were primed to capitalize on changing demographic structures, maximally attain the demographic dividend, and augment socio-economic growth.
Methods: We conducted policy reviews by focusing on five key sectors of the Gates Institute Demographic Dividend Framework: Family Planning, Maternal and Child Health, Education, Women’s Empowerment, and Labor Market. This framework was developed as a tool for countries to apply targeted policies for accelerating the demographic dividend based on their demographic structure. For each component we used a comprehensive list of indicators, defined via a systematic literature review, through which we assessed national policies aimed at maximizing the demographic dividend.
Results: Between the two countries, we observed persistent gaps in policies targeting family planning. Although more comprehensive, policies addressing maternal and child health, education, women’s empowerment, and labor market still lagged in their specificity and measurability. We identified specific policy amendments and alternatives that Nigeria and Tanzania could consider to mitigate these gaps. We also stress the importance of designing measurable policy initiatives across sectors.
Conclusions: Based on these recommendations, as Nigeria, Tanzania, and other pre-dividend nations start experiencing rapid demographic changes, they may consider implementing routine policy reviews to strengthen policies across the five key sectors and harness the benefits of a demographic dividend.
Upregulated host genes during the disease progression of bovine leukemia virus independent on overexpression of viral transcriptional regulators in vitro
Authors: Nishimori Asami , Andoh Kiyohiko , Matsuura Yuichi , Kohara Junko , Hatama Shinichi 
Published: September 2022

Abstract
Bovine leukemia virus (BLV) is a member of the genus Deltaretrovirus within the Retroviridae family that infects bovine B cells, causing persistent lymphocytosis and enzootic bovine leukosis (EBL) in a small fraction of infected cattle. As changes in the profiles of the infected-cell transcriptome are important for BLV disease progression, comprehensive analyses to clarify gene expression in different disease states are required. In this study, we performed an RNA-seq analysis using samples from non-EBL cattle infected or uninfected with BLV. Subsequently, a transcriptome analysis was conducted in combination with previously obtained RNA-seq data from EBL cattle. We found several differentially expressed genes (DEGs) between the three groups; subsequently, after screening and validation of target DEGs using real-time reverse transcriptase polymerase chain reaction, we found that 12 target genes were significantly upregulated in EBL cattle compared to BLV-infected cattle without lymphoma. In addition, the expression levels of B4GALT6, ZBTB32, EPB4L1, RUNX1T1, HLTF, MKI67, and TOP2A were significantly and positively correlated with the proviral load in BLV-infected cattle. Overexpression experiments revealed that these changes were independent of BLV-tax or BLV-AS1-S expression in vitro. Our study provides additional information on host gene expression during BLV infection and EBL development, which may be helpful for understanding the complexity of transcriptome profiles during disease progression.
Patient and Public Involvement (PPI) in outcome selection in breast cancer and nephrology trials
Authors: Buckley Ciara , Treweek Shaun , Laidlaw Lynn , Shiely Frances 
Published: September 2022

Abstract
We recently reported that according to patients and health care professionals in breast cancer and nephrology trials, teams conducting the trials got their choice of primary outcome wrong (72% of the time) more often than they got it right (28% of the time). A PPI (patient and public involvement) representative, co-author of this letter, asked (on twitter) whether PPI contributors had been involved in the design of the original trials and by extension the outcome selection. The purpose of this study was to answer this question.
Do maternal albumin levels affect post-operative complications after cesarean delivery?
Authors: Yagur Yael , Ribak Rachel , Ben-Ezry Emili , Cohen Ido , Or-Madar Libby , Kovo Michal , Biron-Shental Tal 
Published: September 2022

Abstract
Background: This study explored the correlation between maternal serum albumin levels prior to elective CD and postoperative complications.
Methods: This retrospective cohort study included women admitted for elective CD at term to our tertiary referral center during the years 2016-2018. Blood samples were collected during the preoperative admission. Information collected included maternal demographics, pregnancy and postoperative complications. Data between patients with preoperative serum albumin levels ≤ 3.4 g/dL or > 3.4 g/dL were compared.
Results: Among 796 women admitted for an elective CD, 537 met the inclusion criteria. There were 356 (66.3%) women in the low albumin level group (≤ 3.4 g/dL) and 181 (33.7%) with serum albumin level > 3.4 g/dL. Patients with serum albumin >3.4 g/dL had increased rates of SSI (6.1% vs. 2.5% respectively; p=0.04), need for antibiotics during the post-partum period (13.3% vs 4.2%, respectively; p<0.001), surgical intervention (5% vs. 1%, respectively; p=0.02) and rehospitalization rate (7.2% vs. 0.8%, respectively; p<0.001). Multivariant analysis showed albumin level >3.4 g/dL was independently associated with composite postoperative, maternal adverse outcome.
Conclusions: High serum albumin levels among women undergoing CD, might be associated with abnormal postoperative outcomes. Larger prospective studies, with a heterogenous population are needed to validate these observations.