bluuebunny/crossref_metadata_2025_split huggingface dataset:
L–carnitine improves developmental competence of buffalo oocytes in vitro
Authors: Modak Avijit Kumar , Islam Nuronnabi , Khatun Asma , Alam Hasanur , Akter Ireen , Kabir AKM Ahsan , Hashem Abul , Moniruzzaman Mohammad 
Published: September 2022

Objective:
To investigate the effect of L-carnitine on in vitro maturation and subsequent in vitro embryo production of buffalo oocytes.

Methods:
Cumulus oocyte complexes (COCs) were aspirated from ovaries of slaughtered buffaloes. COCs were classified into good and fair qualities based on morphological observation of numbers and integrity of cumulus cells surrounding the oocyte. Both categories of COCs were placed in in vitro maturation medium with supplementation of different concentrations (0, 0.250, 0.375 or 0.500 mg/mL) of L-carnitine. Oocytes from both qualities were in vitro fertilized and in vitro cultured for 7 days, to examine the developmental competence.

Results:
Supplementation of L-carnitine to in vitro maturation medium increased the cumulus cell expansion rate of COCs to grade A, and reduced the cumulus cell expansion of COCs to grade B and grade C in both good and fair quality oocytes. Similarly, L-carnitine induced the in vitro meiotic progression of buffalo oocytes to metaphase Π in both good and fair quality oocytes. Additionally, L-carnitine reduced the rate of oocyte degeneration in both good and fair quality oocytes. L-carnitine increased the rate of cleaved formation at day 2 and blastocyst formation at day 7 during in vitro culture in both qualities of oocytes. Moreover, a higher rate of blastocyst production was observed in L-carnitine-treated fair quality oocytes, which was higher than the results in the untreated good quality oocytes.

Conclusions:

L-carnitine enhances meiotic maturation and subsequent embryo development from both good and fair quality buffalo oocytes.
Efficacy and Safety of Traditional Chinese Medicine Combined with Western Medicine for the Treatment of Covid-19: A Systematic Review and Meta-Analysis
Authors: Tian Shanshan , Yuan Kai , Zheng Yongbo , Gao Xuejiao , Chen Xuan , Yang Yingbo , Meng Shiqiu , Cao Lu , Shi Le , Yan Wei , Liu Xiaoxing , Shi Jie , Lu Lin , Deng Jiahui , Bao Yanping 
Published: September 2022

Abstract
Coronavirus disease 2019 (COVID-19) has rapidly spread worldwide. Traditional Chinese Medicine (TCM) was considered important by Chinese health authorities in the fight against COVID-19. This review systematically analyzed and evaluated the safety and efficacy of TCM combined with Western Medicine (WM) for the treatment of COVID-19. We sought to provide summary evidence for clinicians when using TCM. We searched for studies in PubMed, Web of Science, Embase, Medline, the Cochrane Library, China National Knowledge Infrastructure, and Wanfang Data from database inception to June 1, 2021. Overall, 31 studies (14,579 participants) were involved in the final systematic review, including 15 randomized controlled trials and 16 observational studies. TCM combined with WM showed main outcomes of a higher clinical efficacy rate (odds ratio [OR] =2.48, 95% confidence interval [CI] =1.90–3.24, I
2 = 4%) and lower case fatality rate (OR = 0.31, 95% CI = 0.19–0.49, I
2 = 80%) compared with WM treatment alone. No significant overall adverse events were found between TCM plus WM group and WM group (OR = 1.43, 95% CI = 0.63–2.23, I
2 = 75%). Some larger randomized control trials would assist in defining the effect of TCM combined with WM on the treatment of COVID-19 complications such as cardiac injury. TCM combined with WM may be safe and effective for the treatment of COVID-19.
Effects of Perceived Stress with Musculoskeletal Pain in Hong Kong
Authors: Wing Ho Pui , Low Adrian , Lam Joey 
Published: September 2022

Abstract

Objective:
Previous psychological research has been made on the role of perceived stress on musculoskeletal pain among adolescents and people working in different job sectors. However, no research has been made on this subject toward the Chinese population and especially the Hong Kong population. Hence, the objective of this research is to evaluate the effects and relationship between perceived stress and musculoskeletal pain and identify the statistical reasoning results of the research through looking into the specific situation in Hong Kong.

Methods:
In this research, data from Perceived Stress Scale-14 and a self-made pain questionnaire on perceived stress and musculoskeletal pain were collected from the patients of a registered chiropractor in Hong Kong to provide an in-depth study of how musculoskeletal pain correlated with perceived stress and how an individual's mental health would further be affected by both subjects among the Hong Kong population.

Results:
The findings of the research indicated that perceived stress is correlated with a combination of rather than one type of musculoskeletal pain and there is a significant correlation between one's posture, musculoskeletal pain, and psychological distress. In addition, in terms of the situation in Hong Kong; the working lifestyle and the prevalence of sedentary lifestyle may act as a risk factor on the results related to one's posture being correlated to musculoskeletal pain and perceived stress.

Conclusion:
It is hoped that this research could enlighten people working in the clinical psychology and chiropractor industries in Hong Kong on the subject of perceived stress and musculoskeletal pain and inform psychology researchers from other countries the situation regarding bodily pain and perceived stress in Hong Kong.
Anti-Inflammation Relieving Heart Dysfunction and Depressive Behaviors of Mice Under Myocardial Infarction and Chronic Stress
Authors: Zhang Lijun , Tao Shuhui , Lu Nan , Pan Ruoyu , Liu Meiyan 
Published: September 2022

Abstract

Background:
Myocardial infarction (MI) induces high morbidity all over the world. Patients with MI are more vulnerable to depression, and depression worsens their prognosis. Inflammatory response is the primary pathophysiological mechanism of MI combined with depression. Therefore, MI and depression would benefit from attenuating inflammation.

Objectives:
To explore the anti-inflammation effect in relieving heart dysfunction and depressive behaviors of mice under MI and chronic stress.

Materials and Methods:
A total of 40 male C57BL/6J mice were given sham or MI surgery, and the success rate of the surgery was 80%. Hence, 32 mice survived surgery and were distributed as 8 in each group of study. Then, unpredictable chronic mild stress (UCMS) or Anshen Buxin Liuwei pills (ABL pills) group were applied to some MI mice, and the mice were divided into different groups, including sham group, MI group, MI + UCMS group, and MI + UCMS + ABL pills group (n = 8). After a 2-week treatment, the mice underwent the sucrose preference test, and echocardiography before sacrifice. Then, the mice were sacrificed for pathological detection and inflammatory cytokines detection.

Results:
Compared with mice in the sham group, those mice had lower left ventricular ejection fraction (LVEF) (51.25 ± 9.92 vs. 12.18 ± 8.46, 20.95 ± 16.40, 29.55 ± 13.33%, P< 0.05) and left ventricular fractional shortening (LVFS) (21.12 ± 6.82 vs. 5.57 ± 4.0, 9.89 ± 8.03, 14.0 ± 6.65%, P< 0.05) in the MI, MI + UCMS, and MI + UCMS + ABL pills groups. ABL pills could reverse cardiac dysfunction for the significant elevation of LVEF and LVFS. The hematoxylin and eosin staining presented left ventricular (LV) enlargement, inflammatory cell infiltration, and myocardial fibrosis formation in MI and MI + UCMS mice. While ABL pills reversed the pathological changes induced by ligation of the left anterior descending. The enzyme-linked immunosorbent assay detection showed that MI and MI + UCMS elevated the concentrations of cardiac tumor necrosis factor-α (TNF-α) and tumor necrosis factor receptor 1 (TNFR1), which were reduced by ABL pills. ABL pills significantly reversed the depressive behaviors of mice with MI + UCMS (82.97 ± 3.04 vs. 76.07 ± 7.84%, P< 0.05). MI + UCMS group had a higher level of cortex TNFR1 than sham and MI, while ABL pills reversed the elevation (P > 0.05).

Conclusions:
Anti-inflammation treatment effectively improves cardiac function and depressive behaviors via inhibiting TNF-α/TNFR1.
Perioperative outcomes following robot-assisted partial nephrectomy for complex renal masses
Authors: Sharma Gopal , Shah Milap , Ahluwalia Puneet , Dasgupta Prokar , Challacombe Benjamin J. , Bhandari Mahendra , Ahlawat Rajesh , Rawal Sudhir , Buffi Nicolo M. , Sivaraman Ananthakrishnan , Porter James R. , Rogers Craig , Mottrie Alexandre , Abaza Ronney , Rha Khoon Ho , Moon Daniel , Thyavihally Yuvaraja B. , Parekh Dipen J. , Capitanio Umberto , Maes Kris K. , Porpiglia Francesco , Turkeri Levent , Gautam Gagan 
Published: September 2022

Introduction:
Outcomes of robot-assisted partial nephrectomy (RAPN) depend on tumor complexity, surgeon experience and patient profile among other variables. We aimed to study the perioperative outcomes of RAPN for patients with complex renal masses using the Vattikuti Collective Quality Initiative (VCQI) database that allowed evaluation of multinational data.

Methods:
From the VCQI, we extracted data for all the patients who underwent RAPN with preoperative aspects and dimensions used for an anatomical (PADUA) score of ≥10. Multivariate logistic regression was conducted to ascertain predictors of trifecta (absence of complications, negative surgical margins, and warm ischemia times [WIT] <25 min or zero ischemia) outcomes.

Results:
Of 3,801 patients, 514 with PADUA scores ≥10 were included. The median operative time, WIT, and blood loss were 173 (range 45–546) min, 21 (range 0–55) min, and 150 (range 50–3500) ml, respectively. Intraoperative complications and blood transfusions were reported in 2.1% and 6%, respectively. In 8.8% of the patients, postoperative complications were noted, and surgical margins were positive in 10.3% of the patients. Trifecta could be achieved in 60.7% of patients. Clinical tumor size, duration of surgery, WIT, and complication rates were significantly higher in the group with a high (12 or 13) PADUA score while the trifecta was significantly lower in this group (48.4%). On multivariate analysis, surgical approach (retroperitoneal vs. transperitoneal) and high PADUA score (12/13) were identified as predictors of the trifecta outcomes.

Conclusion:
RAPN may be a reasonable surgical option for patients with complex renal masses with acceptable perioperative outcomes.
In-vivo evaluation of chondroprotective activity of Ariflex tablet in comparison with aceclofenac tablet and chondroitin sulfate/glucosamine (CG) in monosodium iodoacetate-induced osteoarthritis in rats
Authors: Nipanikar Sanjay U. , Patil Manohar J. , Kadam Prasad V. 
Published: September 2022

Background:
Degenerative changes in a joint subsequent to alterations in cartilage formation equilibrium lead to development of osteoarthritis (OA).

Aims:
Chondroprotective activity of Ariflex tablet (a polyherbal formulation) was evaluated in comparison with chondroitin/glucosamine and aceclofenac in monosodium iodoacetate-induced OA in Wistar rat models.

Materials and Methods:
A total of 42 animals were divided into seven groups, viz., four control groups [negative, positive, standard and vehicle controls] and three test groups [low, medium, and high dosages]. Animals in seven groups were treated with various study drugs for the period of 28 days. In this study period, measurement of body weight and knee joint swelling was done periodically. Gait score was recorded on the last day, and histopathological examination of joints was done after sacrificing the animals.

Results:
Chondroprotective activity of medium and high dose of Ariflex tablet was comparable to that of aceclofenac and superior to chondroitin + glucosamine combination. In few rats of medium and high dose of Ariflex tablet groups, chondrocyte regeneration and formation of new blood vessels were seen, which indicated possibility of chondrocyte regeneration activity of Ariflex tablet.

Conclusion:
Ariflex tablet possesses significant chondroprotective activity comparable to aceclofenac and superior to chondroitin and glucosamine combination. There was a possibility of chondrocyte regeneration activity of Ariflex tablet, which can be confirmed by conducting another study with long-term treatment.
Pharmacognostical and phytochemical standardization on stem bark of Mahonia nepalensis DC.
Authors: Paudel Kiran , Ramamurthy Aku , Sharma Gaurav 
Published: September 2022

Introduction:
The tribal people cure hepatic-related disorders with the stem bark of Mahonia nepalensis DC.

Aim:
The aim of the study was to do Investigation of the Microscopic and Macroscopic Characteristics, Pharmacognostical, Physiochemical Parameters, and Thin Layer Chromatography of Stem Bark of Mahonia nepalensis DC.

Materials and Methods:

Mahonia nepalensis DC. were collected from natural habitat and authenticated by the proper plant authentication centers. The cell composition of TS slices was examined after they had been dyed and mounted. The powders of the sample drug were studied organoleptically. The Extractive values and Ash values were represented in Pie-chart form designed by using Microsoft Excel.

Results:
The Bark of the Mahonia nepalensis DC. is brown in color externally but the inner side is yellow with features of general anatomy of dicot stem on transverse section. The pharmacognosy and phytochemical investigations of the stem bark of Mahonia nepalensis DC shows presence of starch grain, intermedullary rays as diagnostic characters. Mayer’s reagent test and Dragon Droff’s reagent test are positive in the test signifies that the present of Alkaloids and TLC values were evaluated.

Conclusion:
The key diagnostic characteristics of Mahonia nepalensis DC’s stem were identified from its pharmacognosy. The stem of Mahonia nepalensis DC was authenticated and subjected to quality control using phytochemical tests and TLC, which were derived and described.
Stanyakshya (insufficient lactation) and its management by an Ayurveda formulation
Authors: Sharma Upasana , Sharma Sushila 
Published: September 2022

Introduction:
Human milk is an indispensable need for infant survival. As it contains thousands of micronutrients, macronutrient, bioactive components, immunological factors that gives immense protection against infection and inflammation. In Ayurveda classics, Stanya (breast milk) has given a very pivotal place for baby. But currently many mothers are not fortunate enough to feed their new born due to deficient support from their health. After reviewing Ayurveda classics, it can be concluded that major cause of lactation insufficiency in Sutikaawastha(puerperium) is Agnimandya and Dhatu/Updhatukshaya. For such conditions, judicial selection of drugs is very important, as in Ayurveda number of Stanyajanana and Stanyavardhaka drugs (galactogogues) are mentioned for initiationand augmentation of milk production.

Materials and Methods:
Following is a case report of a 32-year-old female who was not able to feed her baby properly even after seven days of normal delivery. She was treated with a simple decoction of DeepenaPaachana drugs; Shatapushpa, Dhanyaka, KrishnaJeeraka etc. Results were assessed on the basis of subjective parameters; mother - Stanyapravriti in a day, baby - Shishurodana, Bharavridhi, Nidra etc. All the medications were given for 42 days and all the parameters were assessed and found with in normal limit.

Conclusion:
Main cause for insufficient milk production in this case and many more like this is Agnimandya at the level of Jatharagni as well as Dhatwagni also. By correcting condition of Agni,one can easily manage such cases, there is no need to give Stanyavardhana drugs to all the patients.
Efectos en las funciones ejecutivas por el consumo de cannabis en jóvenes
Authors: Noj García Joseline Daniela , Ramírez López Rocio Michelle 
Published: September 2022

OBJETIVO: describir los efectos por el consumo de cannabis desde las funciones ejecutivas en el sistema nervioso. METODO: construcción teórica con base a reflexiones
RESULTADOS: la historia sobre el uso del cannabis indica que ha sido utilizada en todas partes del mundo de diversas formas; generalmente orientadas a distintos propósitos; algunos de ellos pueden ser: medicinales, recreativos, de carácter religioso/ ceremonial e incluso como inductor psíquico. Es por esta dinámica social histórica, apertura y aceptación al consumo de cannabis por parte de la sociedad actual que se realiza este acercamiento a las diferentes alteraciones a nivel psicológico y cognitivo asociadas. CONCLUSIÓN: los consumidores crónicos de cannabis presentan cambios en el funcionamiento cognitivo principalmente en procesos de memoria, aprendizaje, atención, flexibilidad cognitiva y toma de decisiones afectando el desempeño efectivo de actividades cotidianas. El deterioro repercute en los factores ocupacionales como la educación, las relaciones sociales y el desempeño laboral; en su mayoría de casos, en consumidores adolescentes, teniendo mayor repercusión en esta población debido a la falta de maduración cerebral que impide que las funciones ejecutivas realicen su función correctamente.
Los trastornos del lenguaje desde la perspectiva neurocientífica
Authors: Chán Tesucún Marleny Esmeralda 
Published: September 2022

OBJETIVO: describir los trastornos del lenguaje desde la neurociencia METODO: construcción teórica con base a reflexión RESULTADOS: el ser humano por naturaleza vive en interacción con otros a través del acto comunicativos, siendo el medio que permite la interacción con el uso de códigos lingüísticos, que consiste en articulación del aparato fonador para emisión correcta de la palabra, frase y oraciones CONCLUSIÓN: los trastornos del lenguaje que son limitantes para el proceso comunicativo, que a la vez hay interrelación entre el lenguaje con las áreas cerebrales, que facilitan o limitan la codificación y descodificación entonces esto dificulta el proceso cognitivo del ser humano, que repercute en el quehacer diario de la vida.
EFEKTIVITAS PENGAWASAN DINAS PERINDUSTRIAN DAN PERDAGANGAN KABUPATEN TABANAN DALAM PENGELOLAAN PASAR TRADISIONAL DAUH PALA KECAMTAN TABANAN KABUPATEN TABANAN
Authors: Wibawa I Ketut Sukantha Artha 
Published: September 2022

Penelitian ini mengambil judul Efektivitas Pengawasan Dinas Perindustrian Dan Perdagangan Kabupaten Tabanan Dalam Pengelolaan Pasar Tradisional Dauhpala Kecamatan Tabanan Kabupaten Tabanan. Dengan menggunakan Teknik purposive sampling. Dengan indikator: Akurat, Terpusat, Tepat waktu, Fleksibel, Bersifat sebagai petunjuk dan opersaional. Metode penelitian yang digunakan adalah penelitian kualitatif dengan rancang bangun observasional deskriptif. Teknik penelitian yang dilakukan dengan cara survei lapangan, wawancara, dan studi literatur.Hasil penelitian menyatakan bahwa pengawasan di Pasar Dauhpala dengan indikator yang disebutkan di atas belum dapat dikatakan efektif, masih banyak adanya permasalah yang belum dapat diselesaikan oleh Dinas Perindustrian dan Perdagangan Kabupaten Tabanan. Dengan berbagai hambatan yang di hadapai Dinas Perindustrian dan Perdagangan Kabupaten Tabanan seperti kurangnya sarana dan prasarana, serta anggaran yang belum memadai. Saran yang bisa penulis berikan sebagai berikut, dalam melakukan pengawasan tidak hanya dilakukan seminggu sekali, atau pada saat tertentu saja.Dalam melakukan pengawasan petugas seyogianya mampu juga menyampaikan arahan bagi pedagang yang pola fikirnya masih kaku agar terciptanya budaya tertib dan bersih.untuk melaksanakan pengawasan yang efektif, perbanyak sarana pengawasan seperti kendaraan bermotor.
Optimasi Kapasitas Produksi Dengan Integer Linear Programming (ILP) Dalam Perencanaan Jadwal Induk Produksi Di PT Indonesia Epson Industry
Authors: Sitorus Helena , Rosihan Rifda Ilahy , Fizai Muhammad 
Published: September 2022

PT. Indonesia Epson Industry (IEI) adalah perusahaan yang memproduksi printer. Produk model Newmar masih memiliki Sisa Order Produksi (SOP) rata-rata sebesar 3,14% per tahun. SOP merupakan jumlah order yang tidak dapat dipenuhi. SOP terjadi karena ketidakseimbangan antara kapasitas yang dibutuhkan dengan kapasitas yang tersedia. Ketidakmampuan pabrik dalam mencapai target produksi tepat waktu dikarenakan Jadwal Induk Produksi (JIP) yang dibuat tidak disesuaikan dengan kapasitas yang tersedia. Untuk itu dilakukan penelitian yang bertujuan mengoptimalkan kapasitas produksi dalam penyususnan JIP dengan meminimumkan SOP sehingga diperoleh profit tertinggi. Solusi optimum dihitung dengan Integer Linier Programming (ILP). Hasil temuan penelitian menunjukkan bahwa penambahan komputer sebanyak 7 di SK-3 dan sebanyak 4 di SK-6 memberikan profit tertinggi dibandingkan penambahan jam lembur dan penambahan karyawan. Profit dengan penambahan computer meningkat sebesar 21,5% dibandingkan dengan kondisi tanpa penambahan kapasitas.
COMPLICAÇÕES PRECOCES E TARDIAS MAIS FREQUENTES PÓS-TRANSPLANTE CARDÍACO EM PACIENTES PORTADORES DE INSUFICIÊNCIA CARDÍACA
Authors: Oliveira Karasek Hazime Desiree , Guimarães Rodrigues Mariana , Póvoa Lemes Neto Edílio , De Souza Endres Vitória , Melocro Manoela , Teixeira Duarte Thaís , Reis de Olégario Welton John , Martins de Araujo Anna Lecticia , Targino Freire Iza Bianca , Lolli Bordoni Silva Maria Elisa , Cerqueira Navarro Probst Aline , Zoca Buss Priscila , Rochemback Liliane , Amâncio da Silva Ana Carolina 
Published: September 2022

A doença cardiovascular é uma das principais causas de óbito no mundo, tendo a insuficiência cardíaca como sua principal complicação. Nos casos refratários, o transplante cardíaco é o padrão-ouro para o tratamento. Apesar disso, para que os pacientes sejam candidatos a essa abordagem cirúrgica, tanto os doadores, quanto os receptores necessitam passar por uma avaliação cautelosa dos critérios de inclusão e exclusão, de acordo com a New York Heart Association (NYHA), a fim de que se evitem complicações no pós-operatório. Dentre essas complicações, estão presentes as precoces e as tardias, objetivo de abordagem dessa revisão bibliográfica a partir de estudos relevantes relacionados ao tema.
Segmentation of orbital and periorbital lesions detected in orbital magnetic resonance imaging by deep learning method
Authors: Aydın Nevin , Saylısoy Suzan , Celik Ozer , Aslan Ahmet Faruk , Odabas Alper 
Published: September 2022

IntroductionMagnetic resonance imaging (MRI) has a special place in the evaluation of orbital and periorbital lesions. Segmentation is one of the deep learning methods. In this study, we aimed to perform segmentation in orbital and periorbital lesions.Material and methodsContrast-enhanced orbital MRIs performed between 2010 and 2019 were retrospectively screened, and 302 cross-sections of contrast-enhanced, fat-suppressed, T1-weighted, axial MRI images of 95 patients obtained using 3 T and 1.5 T devices were included in the study. The dataset was divided into 3: training, test, and validation. The number of training and validation data was increased 4 times by applying data augmentation (horizontal, vertical, and both). Pytorch UNet was used for training, with 100 epochs. The intersection over union (IOU) statistic (the Jaccard index) was selected as 50%, and the results were calculated.ResultsThe 77th epoch model provided the best results: true positives, 23; false positives, 4; and false negatives, 8. The pre­cision, sensitivity, and F1 score were determined as 0.85, 0.74, and 0.79, respectively.ConclusionsOur study proved to be successful in segmentation by deep learning method. It is one of the pioneering studies on this subject and will shed light on further segmentation studies to be performed in orbital MR images.