bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Future Vertical Life in Phnom Penh
Authors:   , Hout Bunkung 
Published: September 2022

<p><b>Wellbeing is considered health, ecological environment, convenience, security, and safety (Lee et al., 2011), and it also can be satisfied with life and improve living quality (Kamp et al., 2003). Meanwhile, Mason (2018) defines sustainability as natural system function and human civilization, including economic, social, and environmental protection. Cambodia is a famous country with a rich culture, architecture, and natural resources. The capital city of Cambodia-Phnom Penh, which is known as Cambodia’s heart, has been gradually developing from the classic into contemporary life in the last few decades. With the increasing construction, the city now has severe environmental issues such as air pollution and flooding—these problems seriously affect Phnom Penh inhabitants’ mental and physical wellbeing. </b></p>
<p>	As human wellbeing and environmental quality are consistently decreasing in Cambodia as well as the world, the sustainability paradigm was introduced to solve the social, economic, and environmental issues. The focus of the study is on improving the living conditions of the vulnerable communities through regenerative architecture solutions in a rapidly expanding urban city. This research looks at how regenerative design can be implemented in Phnom Penh to enable residents’ wellbeing and sustainability through vertical living environments.</p>
<p>	The architecture will test the concept of the regenerative paradigm by focusing on the interaction between people and nature. Concerning methodological strategies, it will start from literature reviews to design testing. The literature section will investigate Phnom Penh’s urban lifestyle from different eras. The idea of Khmer vernacular architecture and how it has evolved based on changing users will be highlighted. The study looks at economic support systems for the poor as the Grameen Bank as a concept that could back the realization of the vertical village being proposed as a design solution. The concepts of the regenerative paradigm explored in this study relate to materials, renewable energy, ventilation, and waste management for improving human wellbeing and sustainability. </p>
<p>All literature reviews and precedents have both international and national or ASEAN countries as practical examples. The design part of the thesis is about experimenting with a new perspective of regenerative design, the vertical village. The design testing explores Khmer culture and sustainability concepts. Also considered is how the cost of construction and the cost of living can be reduced by an architecture and planning system that is enabling and empowering. The project explores a system for engaging the capacity of the occupants of the housing in the construction of their homes and livelihood opportunities through the production of the building materials, energy, and food for the community. This research looks at how the Khmer people can benefit from an architecture that supports a healthier life in a zero waste environment which looks to safeguard natural sources through recycling.</p>
Karayolu Taşımacılığı Yapan Bir Lojistik Firmasının Araç Seçimi Probleminin Entropi Tabanlı Topsis ve Aras Yöntemleri ile Çözümlenmesi
Authors: OZGUNER Mert , OVALI Esra 
Published: September 2022

Karayolu taşımacılığında sorunsuz bir taşıma işlemi gerçekleştirebilmek için kullanılacak araçların fonksiyonel yapısına dikkat edilmesi oldukça büyük önem taşımaktadır. Bu doğrultuda lojistik firmalarının, taşıma aracı seçimi esnasında bu özelliklerini göz önünde bulundurarak kendi stratejilerine uygun olan taşıma aracını belirlemeleri büyük önem taşımaktadır.
Bu çalışmada Çok Kriterli Karar Verme modellerinden ENTROPİ, TOPSİS ve ARAS yöntemleri kullanılarak karayolu taşımacılığı yapan bir lojistik firmasının araç seçim probleminin çözümüne yönelik çeşitli alternatifler sunmak amaçlanmaktadır. Bu kapsamda, geniş bir literatür araştırması sonucunda araç seçimi için kullanılacak 5 kriter ve en çok tercih edilen 5 araç markası belirlenmiştir. Elde edilen bulgular, araç seçiminde dikkat edilen en önemli kriterin satış sonrası hizmetler olduğunu ortaya koymuştur. Yine belirlenen kriter ağırlıklarına göre öncelikli olarak önerilecek araç markalarının sırasıyla; Mercedes-Benz ve Volvo olduğu sonucuna ulaşılmıştır.
A Grasp-Like Vaginal Lesion in a 15-Months-Old Child: A Case Report
Authors: Guanà Riccardo , Carpino Andrea , Campilongo Carmen , Lonati Luca , Madonia Elena , Garofalo Salvatore , Perucca Giulia , Shilly Steffi , Gennari Fabrizio 
Published: September 2022

ABSTRACT

Introduction and importance:
Rhabdomyosarcoma is the most common pediatric soft tissue sarcoma. It constitutes 4 – 6% of all malignancies in childhood. The botryoid variant is a type of ERMS that is the most common malignancy in the pediatric female genitourinary tract. ERMS of the vagina usually occurs in early childhood, whereas ERMS of the uterus occurs later in age. Since 1959, only 7 cases of uterine botryoid ERMS during infancy have been reported.

Case presentation:
A 15-months-old girl was admitted to our ED for three reddish, smooth, glistening, polypoidal masses protruding from her vaginal introitus for 9 days. The lesions had a suspicious “grape-like” appearance and tended to come in and out through the vaginal ostium. A pelvic US examination on the patient showed an inhomogeneous aspect of the uterus, which appeared to be occupied and stretched out by an iso-hypoechogenic solid tissue. Additionally, there were some hyperechogenic spots inside as well as evidence of vascular signals on color doppler. A surgical biopsy revealed a malignant mesenchymal tumor consistent with the diagnosis of embryonal rhabdomyosarcoma (ERMS), botryoid variant.

Clinical Discussion:
The patient completed her first cycle of chemotherapy with ifosfamide, vincristine, and dactinomycin (IVA). When she was 18 months old, she underwent a hysterectomy, which removed the entire mass with a Pfannenstiel approach. The postoperative course presented with no complications. Follow-up visits were scheduled quarterly.

Conclusion:
Botryoid ERMS of the uterus is a diagnosis not to be missed in an infant. Since rapid diagnosis and treatment are necessary, clinicians should be aware of its presentation to assure optimal management.

Highlights:
Prospects for obtaining low-alkaloid and adaptive forms of narrow-leafed lupinе based on the genome and transcriptome resources of the species
Authors: Vishnyakova M. A. , Krylova E. A. 
Published: September 2022

The narrow-leafed lupinе (Lupinus angustifolius L.) is considered as a crop of untapped opportunities. The food and forage potential of the species is not fully exploited due to the presence of quinolizidine alkaloids (QA) in plants, which are secondary metabolites that make the seeds bitter and toxic to humans and animals. Varieties with a low content of QA (“sweet” varieties) created over the last 50-60 years turned out to be more susceptible to damage by sucking insects and insect-transmitted viruses than high alkaloid ones (“bitter” varieties). Based on the rapidly developing genomic, transcriptomic and metabolomic profiling of the species, some molecular determinants and features of alkaloid biosynthesis in narrow-leafed lupinе plants have been identified: alkaloids are formed in the vegetative organs of the plant and then transported to the seeds. This information substantiated the creation of “bitter-sweet” forms with a high content of alkaloids in the vegetative parts of the plant, which would make it possible to reduce the attack of pathogens, and a minimal content of alkaloids in the seeds. This review summarizes the existing prerequisites for obtaining such forms of narrow-leafed lupinе on the basis of the available scientific developments. Information on the creation of saturated genetic maps of the species, in which the iucundus (iuc) locus determining the overall low alkaloid content in seeds is integrated and is used in breeding programs. The use of the new generation sequencing allowed the identification of the RAP2-7 gene, encoding the transcription factor APETALA2/ETHYLENE RESPONSE FACTOR, which is coupled to the iuc locus and located in the area with the main QTLs that affect the composition of the QA. It is a likely candidate gene for regulating alkaloid content in narrow-leafed lupinе seeds. The initial stages of QA biosynthesis and its regulatory factors have been revealed. Two reference assemblies of the genome of narrow-leafed lupinе have been carried out. All these achievements constitute a valuable resource for the creation of forms of narrow-leafed lupinе with a high content of alkaloids in the vegetative mass and low in the seeds, which are absent in nature.
Characterization of commercial common wheat cultivars for resistance to tan spot causative agent
Authors: Kovalenko N. M. , Shaydayuk E. L. , Gultyaeva E. I. 
Published: September 2022

Tan spot of wheat (pyrenophorosis) is a worldwide spread and economically significant disease of wheat. Growing resistant cultivars is an environmentally friendly method of disease control. The aim of the present work was to assess tan spot resistance in common wheat cultivars recommended for cultivation in the Russian Federation, and to identify the dominant Tsn1 allele using a molecular marker. The assessment involved 39 winter and 31 spring wheat cultivars included in the State Register of Selection Achievement in 2018-2020. Evaluation of wheat resistance was carried out in laboratory conditions under artificial inoculation of seedlings and leaf segments. Two isolates of Pyrenophora tritici-repentis (Died.) Drechs, producing ToxA toxin (I_ToxA) and ToxB toxin (ToxB) were used. The dominant allele of the Tsn1 gene was identified using the Xfcp623 marker. A high level of resistance (R) to both isolates (I_ToxA and I_ToxB) was shown by spring cultivars ‘Grenada’ and ‘Silach’; moderate resistance (MR) was demonstrated by winter cultivars ‘Felicia’ and ‘Akhmat’ and spring cultivars ‘Omskaya 42’, ‘Zauralskaya Zhemchuzhina’, ‘Radmira’, ‘Tarskaya 12’ and ‘Extra’. A resistant reaction (R, MR) to the isolate I_ToxA was typical for 26% of winter cultivars and 45% of spring ones. The number of cultivars resistant to the I_ToxB isolate was significantly higher (59% and 52%, respectively). The total fraction of cultivars resistant to the isolate I_ToxA (reaction R, MR) in the collection of winter wheat was 26% and 45% in the spring wheat collection; while the fractions of cultivars resistant to the I_ToxB isolate in these collections were equal to 59% and 52%, respectively. By using the Xfcp623 marker, the diagnostic product was amplified in winter cultivars ‘Bodry’, ‘Kavalerka’, ‘Timiryazevka 150’, ‘Shef’, ‘Anastasia’, ‘Barynya’, ‘Donskaya Step’, ‘Elanskaya’ and spring cultivars ‘Odeta’, ‘Stolypinskaya 2’, ‘Iren’ 2’ and ‘OMGAU 100’. All these cultivars were moderately susceptible to the isolate I_ToxA, with the exception of ‘Odeta’ and ‘Iren’ 2’, which may indicate a decrease in the expression level of the ToxA gene in genotypes of these cultivars.
PELATIHAN PEMBUATAN PUPUK ORGANIK CAIR PADA KELOMPOK PETANI KOTA
Authors: Mindhayani Iva 
Published: September 2022

Kegiatan pengabdian kepada masyarakat kepada Kelompok Petani Kota (KPK) yang berada di wilayah Kecamatan Kraton tepatnya di Suryoputran RT. 028 RW. 008 bertujuan untuk memberikan edukasi kepada masyarakat tentang pemanfaatan limbah rumah tangga dengan mengolahnya menjadi pupuk organik cair. Metode pendekatan yang digunakan dalam kegiatan pengabdian ini adalah dengan pemaparan materi dan praktik langsung pembuatan pupuk organik cair dari limbah kulit pisang.Â Hasil dari kegiaan pelatihan pembuatan POC yang telah dilakukan dapat disimpulkan bahwa acara berjalan sesuai rencana meskipun masih dalam kondisi pandemic covid-19. Selain itu,Â pengetahuan masyarakat khususnya peserta pelatihan akan pupuk organik cair semakin meningkat. Hal tersebut terlihat dari hasil kuisioner yang diberikan sebelum dan sesudah pelatihan bahwa telah terjadi peningkatan pengetahuan dan pemahaman rata-rata sebesar 80%.
Cooperation Analysis of Tax-Base Sharing in the Twin Cities: School Districts, Human Resources, and Structural Justice
Authors: Backer David I. 
Published: September 2022

This article introduces educational human resource researchers to Minnesota’s unique tax-base sharing program in the Twin Cities metro region. It also introduces a social justice methodology called cooperation analysis for school finance research, and specifically its concept of structural justice. The article applies cooperation analysis to tax-base sharing in the Twin Cities metro region, focusing on human resource expenditure and overall indicators. The analysis finds that the Twin Cities metro region has the highest overall cooperation of any metro region in relevant datasets and the second highest cooperation in human resource expenditure, making it a model to highlight and replicate nationally. However, the analysis also finds that overall cooperation around resource distribution need not imply cooperation in resource expenditure, specifically on human resources. Furthermore, tax-base sharing does not impact cooperation in student population imbalance, nor does it mitigate expropriation with respect to district debt service, trapping the regions’ districts in cycles of austerity.
Gene expression analysis during progression of malignant meningioma compared to benign meningioma
Authors: Maier Andrea D. , Meddis Alessandra , Mirian Christian , Haslund-Vinding Jeppe , Bartek Jiri , Krog Sebastian M. , Nguyen Thi Uyen Phuong , Areškevičiūtė Aušrinė , Melchior Linea C. , Heegaard Steffen , Kristensen Bjarne W. , Munch Tina N. , Fugleholm Kåre , Ziebell Morten , Raleigh David R. , Poulsen Frantz R. , Gerds Thomas A. , Litman Thomas , Scheie David , Mathiesen Tiit 
Published: September 2022

OBJECTIVE
Meningioma is the most common primary intracranial neoplasm. Only 1%–3% of meningiomas are malignant according to the 2016 WHO criteria (WHO grade III). High-grade meningiomas present specific gene expression signatures indicating aggressive growth or recurrence. However, changes in gene expression and in neuroinflammatory gene expression signatures in WHO grade III meningiomas and during progression from WHO grade I or II to grade III are unknown.

METHODS
The authors used a NanoString targeted gene expression panel with focus on 787 genes relevant in meningioma pathology and neuroinflammatory pathways to investigate patients with grade III meningiomas treated at Rigshospitalet from 2000 to 2020 (n = 51). A temporal dimension was added to the investigation by including samples from patients’ earlier grade I and II meningiomas and grade III recurrences (n = 139 meningiomas). The authors investigated changes in neuroinflammatory gene expression signatures in 1) grade I meningiomas that later transformed into grade III meningiomas, and 2) grade III meningiomas compared with nonrecurrent grade I meningiomas.

RESULTS
The authors’ data indicate that FOXM1, TOP2A, BIRC5, and MYBL2 were enriched and the HOTAIR regulatory pathway was enriched in grade III meningiomas compared with nonrecurrent grade I meningiomas. They discovered a separation of malignant and benign meningiomas based only on genes involved in microglia regulation with enrichment of P2RY12 in grade I compared with grade III meningiomas. Interestingly, FOXM1 was upregulated in premalignant grade I meningioma years before the grade III transformation.

CONCLUSIONS
The authors found gene expression changes in low-grade meningiomas that predated histological transformation to grade III meningiomas. Neuroinflammation genes distinguished grade III from grade I meningiomas.
A robotic MR-guided high-intensity focused ultrasound platform for intraventricular hemorrhage: assessment of clot lysis efficacy in a brain phantom
Authors: Raghuram Hrishikesh , Looi Thomas , Pichardo Samuel , Waspe Adam C. , Drake James M. 
Published: September 2022

OBJECTIVE
Intraventricular hemorrhage (IVH) is a neurovascular complication due to premature birth that results in blood clots forming within the ventricles. Magnetic resonance–guided high-intensity focused ultrasound (MRgHIFU) has been investigated as a noninvasive treatment to lyse clots. The authors designed and constructed a robotic MRgHIFU platform to treat the neonatal brain that facilitates ergonomic patient positioning. The clot lysis efficacy of the platform is quantified using a brain phantom and clinical MRI system.

METHODS
A thermosensitive brain-mimicking phantom with ventricular cavities was developed to test the clot lysis efficacy of the robotic MRgHIFU platform. Whole porcine blood was clotted within the phantom’s cavities. Using the MRgHIFU platform and a boiling histotripsy treatment procedure (500 W, 10-msec pulse duration, 1.0% duty cycle, and 40-second duration), the clots were lysed inside the phantom. The contents of the cavities were vacuum filtered, and the remaining mass of the solid clot particles was used to quantify the percentage of clot lysis. The interior of the phantom’s cavities was inspected for any collateral damage during treatment.

RESULTS
A total of 9 phantoms were sonicated, yielding an average (± SD) clot lysis of 97.0% ± 2.57%. Treatment resulted in substantial clot lysis within the brain-mimicking phantoms that were apparent on postsonication T2-weighted MR images. No apparent collateral damage was observed within the phantom after treatment. The results from the study showed the MRgHIFU platform was successful at lysing more than 90% of a blood clot at a statistically significant level.

CONCLUSIONS
The robotic MRgHIFU platform was shown to lyse a large percentage of a blood clot with no observable collateral damage. These results demonstrate the platform’s ability to induce clot lysis when targeting through simulated brain matter and show promise toward the final application in neonatal patients.
Evaluation of different remineralization agents in the treatment of natural caries-affected dentin in permanent teeth
Authors: Turkay Ece Yilmazkasapoglu , Kargul Betul , Aydinoglu Aysu Karakas , Yoruc Afife Binnaz Hazar 
Published: September 2022

BACKGROUND: In the preventive treatment protocol, providing remineralization of the tissue in demineralized dentin caries is an important step. OBJECTIVE: In this in vitro study, the effectiveness of remineralization agents in natural caries-affected dentin (NCAD) were investigated. METHODS: Forty caries slices were prepared from permanent molar dentin with International Caries Detection and Assessment System (ICDAS 2) (Code 3). The interventions with 8 days pH cycling were as follows: Deionized water (DW); 5% Sodium Fluoride (5% NaF) Varnish; Casein Phosphopeptide-Amorphous Calcium Fluoride Phosphate (CPP-ACFP); Calcium Glyserophosphate (CaGP) + Magnesium (Mg) + Xylitol. DIAGNOdent (Laser Fluorescence, LF), Surface Microhardness (SMH), and X-ray Fluorescence (XRF) Spectroscopy measurements were calculated before and after pH cycling. RESULTS: LF values decreased between 5% NaF, CCP-ACFP and CaGP. NCAD treated with 5% NaF, CaGP and CCP-ACFP exhibited statistically higher hardness compared to the control group. After 5% NaF application, SMH values were significantly higher than the others. There was no statistically significant difference between baseline and after pH cycling hardness of the control group. After cycling, XRF showed that Ca and P concentrations were increased in all groups. CONCLUSION: The application of agents used in the study could be recommended and promoted as a treatment option of caries dentin for conventional management of caries.
INTELLIGENT TRANSPORT SYSTEMS AS TRAFFIC FLOW MANAGEMENT TOOL (THE CASE OF KYIV)
Authors: Cherednichenko Oleksandra , Valackienė Asta 
Published: September 2022

The low quality of public transport services, the inconvenience of routes, the long duration of trips and several other problems encourage Kyiv residents to increasingly choose a car for everyday correspondence, which, in turn, increases delays, travel time and leads to environmental pollution of territories. These problems are especially acute in large cities, where numerous industrial, labour, and cultural and household connections are within the city. There is a need to create a single efficient transport system that serves as a city and implement effective traffic flow management approaches.
First of all, the article defines the concepts of "traffic flow management", "urban mobility" and "urban mobility regime". Four groups of problems of urban transport systems were identified and two ways of solving them were formed: extensive and intensive. Using the instrumental case of Kyiv, the level of implementation of systems for monitoring and managing traffic flows in Ukrainian cities was evaluated. The levels of the legal framework regulating the urban mobility of the population in Ukraine are described. The characteristics of intelligent transport systems and their key subject areas have been studied. Commonly accepted services for users of intelligent transport systems (ITS) are distinguished and segmented according to the needs of these system users. Features, methods of application and technologies of intelligent transport systems are presented. Services that are a priority for potential users of intelligent transport systems in Ukrainian cities are highlighted. The world experience of the formation and development of intelligent transport systems, as well as European programs for their implementation, is characterized. A SWOT analysis of the implementation of intelligent transport systems in Kyiv was carried out and recommendations were made for the creation of an ITS implementation program in Kyiv.
The information base of the article consists of publications by prominent Ukrainian and foreign researchers, data from the Tom Tom transport analytics service, the current legal framework of Ukraine, which regulates urban transport systems, and urban development strategies. The following methods of scientific research are used in the research process: dialectical method; method of scientific abstraction, analysis and synthesis; method of induction and deduction; comparative method; method of systematization and graphic method.
EFFECT OF DIETARY SUPPLEMENTATION OF BAKER’S YEAST (Saccharomyces cerevisiae) ON GROWTH PERFORMANCE AND CARCASS CHARACTERISTICS OF WEANER RABBITS (Oryctolagus cunniculus)
Authors: Ibrahim Hadiza , GAJERE J.M , ZAHARADEEN A , ABDULMALIK S. U 
Published: September 2022

The study was conducted to evaluate the effect of baker’s yeast (Saccharomyces cerevisiae) supplement on the growth performance and carcass chracteristics of weaner rabbits. A commercial baker’s yeast containing Saccharomyces cerevisiae was used as the dietary supplement, four experimental diets were formulated. Diet 1 (basal diet), which was designated T1 and without supplementation of Saccharomyces cerevisiae, serve as control diet. Diet 2, 3, and 4 were designated T2, T3 and T4 respectively, were supplemented with Saccharomyces cerevisiae at the rate of 20, 40 and 60g per kilogram of basal diet. The diets were in form of grain. Thirty six (36) weaner rabbits of mixed sex at ratio 2:1 (Females: male) were randomly allotted to four treatment groups in a complete randomized design. Each treatment was replicated three times with three rabbits per replicate. The trial lasted for a period of 8 weeks. Data on growth (initial growth, final weight, daily weight gain, total concentrate intake, total feed intake and feed conversion ratio) and carcass characteristics (cut-up parts and visceral organs) were recorded. The results obtained revealed no significant (P>0.05) differences among the growth performance parameters except for feed intake which was higher (P<0.05) in the control compared to T3 (40g/kg). Carcass characteristics of the experimental animals showed no significant (P>0.05) difference in almost all the parameters measured with the exception of the neck. The values of internal organs and by-products revealed no significant (p<0.05) difference in all the values obtained.