bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection, characterization, and antimicrobial susceptibility of Yersinia enterocolitica in different types of wastewater in the Czech Republic
Authors: Roulová Nikola , Moťková Petra , Brožková Iveta , Brzezinska Maria Swiontek , Pejchalová Marcela 
Published: August 2022

Abstract

Aims
The purpose of the study was to evaluate the occurrence of Yersinia enterocolitica in different types of wastewater and to characterize the isolates by biotyping, serotyping, and antimicrobial susceptibility testing. In addition, cultivation protocols were evaluated.

Methods and Results
The occurrence of Y. enterocolitica was determined in treated and untreated municipal wastewater, as well as in hospital, slaughterhouse, and cowshed wastewater. Y. enterocolitica was detected in 84.1% of the wastewater samples, while the main sources were untreated municipal and slaughterhouse wastewater. In contrast, the lowest incidence was found in hospital wastewater. An exclusive occurrence of biotype 1A (98.3%) was detected. Pathogenic bio-serotypes 4/O:3 and 3/O:3 were isolated only from slaughterhouse wastewater. The highest resistance rates were observed for ampicillin (92.5%) and amoxicillin-clavulanic acid (36.8%).

Conclusions
Y. enterocolitica was commonly detected in wastewater, although the prevalence varied depending on the origin of the wastewater. No single cultivation protocol was able to recover Y. enterocolitica isolates from such a complex matrix as wastewater.

Significance and Impact of the Study
Our study provided data that can contribute to the evaluation of wastewater as a source of Y. enterocolitica and to understanding the threat of wastewater isolates to human health.
The barriers and facilitators to managing diabetes with insulin in adults with intellectual disabilities: A systemised review of the literature
Authors: Beresford Cathy J. , Kozlowska Olga 
Published: August 2022

AbstractBackgroundPeople with intellectual disabilities are more likely to have diabetes and develop complications from it. Diabetes management is complex and insulin treatment in particular, people with intellectual disabilities may require additional support that is not always available. This review aimed to identify barriers and facilitators to managing diabetes with insulin in adults with intellectual disabilities.MethodPatient and public involvement (PPI) was integral to the development of the research question. A systemised review was conducted across CINAHL, the British Nursing Index and MEDLINE. PRISMA guidelines were followed. Narrative synthesis of the evidence was undertaken.ResultsBarriers and facilitators to managing diabetes with insulin in people with intellectual disabilities were identified related to the individual, other people participating in their care, and broader environmental and social factors.ConclusionsPeople with intellectual disabilities who use insulin, require reasonable adjustments to education, support, and a person‐centred approach to facilitate supported self‐management. More training for their supporters is needed and further inclusive research with PPI is recommended.
Evaluation of plasma‐activated water characteristics and its process optimization
Authors: Perinban Sellam , Orsat Valérie , Gariepy Yvan , Lyew Darwin , Raghavan Vijaya 
Published: August 2022

AbstractPlasma‐activated water (PAW) is an emerging technology for the disinfection of foods and it is also widely evaluated for its applications in medicine. The long‐lived reactive oxygen species such as hydrogen peroxide and ozone are mainly responsible for the disinfecting properties of Ar/O2 PAW. In this study, PAW characteristics were evaluated with respect to the process conditions and the post‐treatment time to understand the effect of process conditions and the time stability of PAW. PAW was generated using a continuous flow dielectric barrier discharge Ar/O2 atmospheric pressure plasma system at different PAW treatment times. PAW properties were evaluated based on the concentration of hydrogen peroxide, ozone, pH, and the disinfection of Escherichia coli. From the time stability analysis, it was found that the hydrogen peroxide was more stable than ozone in PAW when stored at room temperature for 2 days. The E. coli inactivation was mainly attributed to the H2O2 and ozone concentration than pH. The optimum process condition was found as 104 ml/min water flow rate, 20‐min treatment time and 4 slm gas flow rate for maximum reactive species concentration in PAW.Practical ApplicationsThere is a need for non‐chemical disinfection method of fresh fruits and vegetables, as the present chemical‐based disinfection methods are inefficient in controlling food‐borne outbreaks and the residual toxicity of these chemicals. Plasma‐activated water (PAW) is an emerging technology, which has the potential in disinfecting microorganisms. The aim of the work was to analyze the disinfection properties and the time stability of PAW. It is evident from the results that PAW is effective in disinfecting Escherichia coli and its reactive species degrade with time. This will facilitate the application of PAW as a disinfectant for fresh fruits and vegetables without any residual toxicity to the food and the environment. Further, from the optimization studies, understanding of the influence of process parameters on the PAW characteristics was derived which will be helpful to scale‐up of this technology.
Systemic lupus erythematosus and cardiovascular disease
Authors: Frostegård Johan 
Published: August 2022

AbstractThe prognosis in systemic lupus erythematosus (SLE) has improved due to better treatment and care, but cardiovascular disease (CVD) still remains an important clinical problem, since the risk of CVD in SLE is much higher than among controls. Atherosclerosis is the main cause of CVD in the general population, and in SLE, increased atherosclerosis, especially the prevalence of atherosclerotic plaques, has been demonstrated. Atherosclerosis is an inflammatory condition, where immunity plays an important role. Interestingly, oxidized low‐density lipoprotein, defective clearance of dead cells, and inflammation, with a pro‐inflammatory T‐cell profile are characteristics of both atherosclerosis and SLE. In addition to atherosclerosis as an underlying cause of CVD in SLE, there are also other non–mutually exclusive mechanisms, and the most important of these are antiphospholipid antibodies (aPL) leading to the antiphospholipid antibody syndrome with both arterial and venous thrombosis. aPL can cause direct pro‐inflammatory and prothrombotic effects on endothelial and other cells and also interfere with the coagulation, for example, by inhibiting annexin A5 from its antithrombotic and protective effects. Antibodies against phosphorylcholine (anti‐PC) and other small lipid‐related epitopes, sometimes called natural antibodies, are negatively associated with CVD and atherosclerosis in SLE. Taken together, a combination of traditional risk factors such as hypertension and dyslipidemia, and nontraditional ones, especially aPL, inflammation, and low anti‐PC are implicated in the increased risk of CVD in SLE. Close monitoring of both traditional risk factors and nontraditional ones, including treatment of disease manifestations, not lest renal disease in SLE, is warranted.
Capital taxation with parental incentives
Authors: Saito Yuta , Takeda Yosuke 
Published: August 2022

AbstractThis paper studies capital taxation in an overlapping generation model where parents regard their children as impatient. The intergenerational time‐preference heterogeneity leads parents to engage in parental monetary transfers designed to encourage their children's asset accumulation (i.e., parental transfers which amount are contingent on the children's savings). In this setup, the utilitarian government's time preference is higher than that of the child generation but lower than that of the parent generation. Hence, from the government's perspective, the strategic parental transfers give too many incentives to accumulate assets. As a result, the government imposes a positive marginal tax on assets to disincentivize the younger generation's saving motives. By contrast, if parents do not have paternalistic preferences and do not make strategic parental transfers, the government imposes a zero marginal tax on assets.
Environmental taxation, information precision, and information sharing
Authors: Elnaboulsi Jihad C. , Daher Wassim , Sağlam Yiğit 
Published: August 2022

AbstractWe analyze how environmental taxes should be optimally levied in a sequential game in which regulators and firms face costs uncertainties. First, the regulator chooses the intensity of emissions taxes to reduce externalities. Then, facing common and private information with noisy signals, firms compete in the marketplace and choose outputs. We show that, under nonuniform quality of signals across firms, the regulator may calibrate differentiated tax policy. We also show that the social impact of more precise private signals hinges largely and fundamentally on the value of the ratio of the slopes of the marginal damage and the marginal consumer surplus. Finally, we investigate information sharing between polluters and its impacts on welfare. We stress that, when there are threats of severe environmental damages under deep uncertainties, collusion is welfare reducing and may jeopardize the regulatory process. Regulators need to set an appropriate precautionary policy. Numerical simulations illustrate the results that the model delivers.
Externalities, entry bias, and optimal subsidy policy for cleaner environment
Authors: Pal Rupayan , Scrimitore Marcella , Song Ruichao 
Published: August 2022

AbstractThis paper analyses alternative subsidy schemes and long‐run entry bias in a new industry that creates positive environmental externalities (both generation externalities and externalities associated with interindustry technology spillovers). It demonstrates that per‐unit subsidy scheme, despite attracting fewer firms, results in higher industry output and economic surplus in the equilibrium compared with the expenditure equivalent lump‐sum subsidy scheme. However, the later leads to higher total surplus, unless spillover externalities are sufficiently small. Further, the free‐entry equilibrium number of firms may be excessive or insufficient. A key finding of this paper is that the first‐best equilibrium outcome can be implemented through a unique combination of per‐unit subsidy and lump‐sum subsidy/tax, which involves positive government expenditure in the presence of positive externalities.
Evidence of an additional centre of apple domestication in Iran, with contributions from the Caucasian crab apple Malus orientalis Uglitzk. to the cultivated apple gene pool
Authors: Bina Hamid , Yousefzadeh Hamed , Venon Anthony , Remoué Carine , Rousselet Agnès , Falque Matthieu , Faramarzi Shadab , Chen Xilong , Samanchina Jarkyn , Gill David , Kabaeva Akylai , Giraud Tatiana , Hosseinpour Batool , Abdollahi Hamid , Gabrielyan Ivan , Nersesyan Anush , Cornille Amandine 
Published: August 2022

AbstractDivergence processes in crop‐wild fruit tree complexes in pivotal regions for plant domestication such as the Caucasus and Iran remain little studied. We investigated anthropogenic and natural divergence processes in apples in these regions using 26 microsatellite markers amplified in 550 wild and cultivated samples. We found two genetically distinct cultivated populations in Iran that are differentiated from Malus domestica, the standard cultivated apple worldwide. Coalescent‐based inferences showed that these two cultivated populations originated from specific domestication events of Malus orientalis in Iran. We found evidence of substantial wild‐crop and crop–crop gene flow in the Caucasus and Iran, as has been described in apple in Europe. In addition, we identified seven genetically differentiated populations of wild apple (M. orientalis), not introgressed by the cultivated apple. Niche modelling combined with genetic diversity estimates indicated that these wild populations likely resulted from range changes during past glaciations. This study identifies Iran as a key region in the domestication of apple and M. orientalis as an additional contributor to the cultivated apple gene pool. Domestication of the apple tree therefore involved multiple origins of domestication in different geographic locations and substantial crop‐wild hybridization, as found in other fruit trees. This study also highlights the impact of climate change on the natural divergence of a wild fruit tree and provides a starting point for apple conservation and breeding programmes in the Caucasus and Iran.
The DASH model: Data for addressing social determinants of health in local health departments
Authors: Petrovskis Anna , Bekemeier Betty , Heitkemper Elizabeth , van Draanen Jenna 
Published: August 2022

AbstractRecent frameworks, models, and reports highlight the critical need to address social determinants of health for achieving health equity in the United States and around the globe. In the United States, data play an important role in better understanding community‐level and population‐level disparities particularly for local health departments. However, data‐driven decision‐making—the use of data for public health activities such as program implementation, policy development, and resource allocation—is often presented theoretically or through case studies in the literature. We sought to develop a preliminary model that identifies the factors that contribute to data‐driven decision‐making in US local health departments and describe relationships between them. Guided by implementation science literature, we examined organizational‐level capacity and individual‐level factors contributing to using data for decision‐making related to social determinants of health and the reduction of county‐level disparities. This model has the potential to improve implementation of public health interventions and programs aimed at upstream structural factors, by elucidating the factors critical to incorporating data in decision‐making.
Influence of the palatal plane cant and skeletal patterns in the hard palate thickness?
Authors: Tavares Alana , Braga Emanuel , Neves Frederico Sampaio 
Published: August 2022

AbstractIntroductionThe aim of the present study was to evaluate the thickness of the hard palate at the different angles formed by the palatal plane and the Frankfort horizontal line using computed tomography in patients with different facial patterns for planning the installation of MARPE.Materials and methodsThe measurements were analysed in the hard palate of 106 patients. Four regions were selected passing through the mesial face, tangent at the level of the cemento‐enamel junction of the premolars and molars. The bone thickness was measured from the floor of the nasal cavity to the cortical bone of the hard palate, 02 measurements with a distance of 05 mm between them (2.5 mm on each side starting from the midsagittal line) and 2 more with a distance of 7 mm between measurements (3.5 mm on each side starting from the midsagittal line). The palatal plane cant was determined based on the palatal plane and the Frankfort horizontal plane. The sagittal skeletal pattern was determined based on the ANB angle and the vertical skeletal pattern based on the SN.Go.Gn angle.ResultsPalatal bone thickness was greater in males than in females. Regarding the sagittal skeletal pattern, patients with Class II were found to have a thinner hard palate than Class I and Class III patients. No difference in the vertical skeletal pattern was observed between groups. Regarding the palatal plane cant, bone thickness was greater in patients with clockwise rotation.ConclusionsCareful planning should be considered in the case of female patients; patients with greater angles of the palatal plane cant and Class II patients have a smaller bone thickness.
Age‐related normal limits for spatial vision
Authors: Keuken Arjan , Subramanian Ahalya , Mueller‐Schotte Sigrid , Barbur John L. 
Published: August 2022

AbstractPurposeTo establish age‐related, normal limits of monocular and binocular spatial vision under photopic and mesopic conditions.MethodsPhotopic and mesopic visual acuity (VA) and contrast thresholds (CTs) were measured with both positive and negative contrast optotypes under binocular and monocular viewing conditions using the Acuity‐Plus (AP) test. The experiments were carried out on participants (age range from 10 to 86 years), who met pre‐established, normal sight criteria. Mean and ± 2.5σ limits were calculated within each 5‐year subgroup. A biologically meaningful model was then fitted to predict mean values and upper and lower threshold limits for VA and CT as a function of age. The best‐fit model parameters describe normal aging of spatial vision for each of the 16 experimental conditions investigated.ResultsOut of the 382 participants recruited for this study, 285 participants passed the selection criteria for normal aging. Log transforms were applied to ensure approximate normal distributions. Outliers were also removed for each of the 16 stimulus conditions investigated based on the ±2.5σ limit criterion. VA, CTs and the overall variability were found to be age‐invariant up to ~50 years in the photopic condition. A lower, age‐invariant limit of ~30 years was more appropriate for the mesopic range with a gradual, but accelerating increase in both mean thresholds and intersubject variability above this age. Binocular thresholds were smaller and much less variable when compared to the thresholds measured in either eye. Results with negative contrast optotypes were significantly better than the corresponding results measured with positive contrast (p < 0.004).ConclusionsThis project has established the expected age limits of spatial vision for monocular and binocular viewing under photopic and high mesopic lighting with both positive and negative contrast optotypes using a single test, which can be implemented either in the clinic or in an occupational setting.
The calcium sensor CBL7 is required for Serendipita indica‐induced growth stimulation in Arabidopsis thaliana, controlling defense against the endophyte and K+ homoeostasis in the symbiosis
Authors: Pérez‐Alonso Marta‐Marina , Guerrero‐Galán Carmen , González Ortega‐Villaizán Adrián , Ortiz‐García Paloma , Scholz Sandra S. , Ramos Patricio , Sakakibara Hitoshi , Kiba Takatoshi , Ludwig‐Müller Jutta , Krapp Anne , Oelmüller Ralf , Vicente‐Carbajosa Jesús , Pollmann Stephan 
Published: August 2022

AbstractCalcium is an important second messenger in plants. The activation of Ca2+ signalling cascades is critical in the activation of adaptive processes in response to environmental stimuli. Root colonization by the growth promoting endophyte Serendipita indica involves the increase of cytosolic Ca2+ levels in Arabidopsis thaliana. Here, we investigated transcriptional changes in Arabidopsis roots during symbiosis with S. indica. RNA‐seq profiling disclosed the induction of Calcineurin B‐like 7 (CBL7) during early and later phases of the interaction. Consistently, reverse genetic evidence highlighted the functional relevance of CBL7 and tested the involvement of a CBL7‐CBL‐interacting protein kinase 13 signalling pathway. The loss‐of‐function of CBL7 abolished the growth promoting effect and affected root colonization. The transcriptomics analysis of cbl7 revealed the involvement of this Ca2+ sensor in activating plant defense responses. Furthermore, we report on the contribution of CBL7 to potassium transport in Arabidopsis. We analysed K+ contents in wild‐type and cbl7 plants and observed a significant increase of K+ in roots of cbl7 plants, while shoot tissues demonstrated K+ depletion. Taken together, our work associates CBL7 with an important role in the mutual interaction between Arabidopsis and S. indica and links CBL7 to K+ transport.
Neuroendocrine tumor G3 of bronchopulmonary origin and its classification
Authors: Kasajima Atsuko , Klöppel Günter 
Published: August 2022

AbstractNeuroendocrine tumors (NET) with high proliferative activity (Ki‐67 index >20% and/or mitotic counts >2 mm2) are defined as NET G3 in the 2019 World Health Organization (WHO) classification of digestive system neuroendocrine neoplasms (NENs). NETs G3 occur mostly in the pancreas, colon, rectum, and stomach and only rarely in the small intestine and the appendix. In the bronchopulmonary system, similar tumors have also been recognized and were mostly classified as atypical carcinoid (AC) or large cell neuroendocrine carcinoma. Bronchopulmonary NENs that were classified as NETs G3 are characterized by histological and immunohistochemical similarities with carcinoids/NETs, and a clinical course that is more aggressive than with ACs and similar to that of neuroendocrine carcinomas. The morphomolecular and clinical features of bronchopulmonary neoplasms with a high proliferative activity were reviewed and a future classification system that is applicable for both digestive and bronchopulmonary NETs is proposed.
Sediment density flow distribution on wave‐influenced deltas
Authors: Normandeau Alexandre , Eamer Jordan B. R. , Bernatchez Pascal , Didier David , Lajeunesse Patrick , Limoges Audrey , Montero‐Serrano Jean‐Carlos 
Published: August 2022

ABSTRACTDeltas are at the transition between fluvial and marine sedimentary environments where sediment density flows are often triggered during high river discharge events, forming submarine channels and sediment waves. On wave‐influenced deltas, longshore currents are particularly efficient at transporting sediment alongshore, reducing the likelihood of sediment density flows from occurring at river mouths. This study describes four deltaic sedimentary systems at different stages of their evolution on a formerly glaciated continental inner shelf of eastern Canada in order to better understand the distribution of sediment density flows on wave‐influenced deltas. Three types of settings are recognized as being prone to sediment density flows: (i) in the early stages of wave‐influence and on large deltas, converging longshore currents can lead to offshelf sediment transport; (ii) on wave‐influenced to wave‐dominated deltas, a sandy spit can re‐route the river mouth and sediment density flows form where the spit intersects the delta lip; (iii) in advanced stages of wave‐dominated deltas and during their demise, rocky headlands are exposed and can intersect the slope, where off‐shelf sediment transport occurs. These types of sediment density flows were all characterized by debris flows or surge‐type turbidity currents which have limited offshore run‐out. More rarely, hyperpycnal flows form at the river mouths, especially where the river incises glaciomarine clays prone to landsliding in the river, which increases fine‐grained fluvial suspended sediment concentration. Overall, these results highlight the predominance of fluvial‐dominated deltas during a phase of relative sea‐level fall combined with high sediment supply. However, as soon as sediment supply diminishes, wave action remobilizes sediment alongshore modifying the distribution and types of sediment density flows occurring on wave‐influenced deltas.