bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of long-term prenatal exposure to 900, 1800, and 2100 MHz electromagnetic field radiation on myocardial tissue of rats
Authors: Bozok Sahin , Karaagac Erturk , Sener Dila , Akakin Dilek , Tumkaya Levent 
Published: November 2022

It is well-known that wireless communication technologies facilitate human life. However, the harmful effects of electromagnetic field (EMF) radiation on the human body should not be ignored. In the present study, we evaluated the effects of long-term, prenatal exposure to EMF radiation on the myocardium of rats at varying durations. Overall, 18 pregnant Sprague-Dawley rats were assigned into six groups ( n = 3 in each group). In all groups other than the control group, three pregnant rats were exposed to EMF radiation (900, 1800 and 2100 MHz) for 6, 12 and 24 h over 20 days. After delivery, the newborn male pups were identified and six newborn male pups from each group were randomly selected. Then, histopathological and biochemical analysis of myocardial samples were performed. When 24-h/day prenatal exposures to 900, 1800, 2100 MHz EMF radiation were evaluated, myocardial damage was greater in the 2100 MHz EMF-24h group than the other groups. In addition, when malondialdehyde (MDA) and glutathione (GSH) levels associated with reactive oxidative species (ROS) were evaluated, the MDA level was higher in the 2100 MHz EMF-24h group compared with the other groups. The GSH level was also lower in the 2100 MHz EMF-24h group. When the 6, 12 and 24 h/day prenatal exposures to 1800 MHz EMF radiation were evaluated, myocardial damage was greater in 1800 MHz EMF-24h group than the remaining groups ( p < 0.0001). Also, MDA level was greater in the 1800 MHz EMF-24h group compared with the other groups while the GSH level was lower in this group. It was shown that myocardial tissue was affected more by long-term exposure to EMF radiation at high frequencies. The data raise concerns that the harmful effects of non-ionizing radiation exposure on cardiac tissue will increase with 5G technology.
The Effects of Loneliness on Depressive Symptoms Among Older Adults During COVID-19: Longitudinal Analyses of the Canadian Longitudinal Study on Aging
Authors: Wister Andrew , Li Lun , Levasseur Mélanie , Kadowaki Laura , Pickering John 
Published: November 2022

Objectives This paper examines the longitudinal effects of changes in the association between loneliness and depressive symptoms during the pandemic among older adults (65+). Methods Baseline (2011–2015) and Follow-up 1 (2015–2018) from the Canadian Longitudinal Study on Aging (CLSA), and the Baseline and Exit waves of the CLSA COVID-19 study (April–December, 2020) ( n = 12,469) were used. Loneliness was measured using the 3-item UCLA Loneliness Scale and depression using the CES_D- 9. Results Loneliness is associated with depressive symptoms pre-pandemic; and changes in level of loneliness between FUP1 and the COVID Exit survey, adjusting for covariates. No interaction between loneliness and caregiving, and with multimorbidity, on depressive symptoms were observed, and several covariates exhibited associations with depressive symptoms. Discussion Strong support is found for an association between loneliness on depressive symptoms among older adults during the pandemic. Public health approaches addressing loneliness could reduce the burden of depression on older populations.
Influence of metro track parameters on vibration characteristics of vibration damping track
Authors: Li Xiang , Ma Jie , Xu Ning 
Published: November 2022

In view of the abnormal wear of the vibration damping track with small radius curve on the subway, the vibration and noise problems associated with it have been widely concerned by society. The dynamic model of vehicle-track system including elastic damping track is established by using simulation software. The influence of structural parameters of steel spring floating slab track (SSFST) with small radius curve on the mode and vibration frequency, as well as the resonance characteristics of elastic track structure are analyzed. The results show the following: (1) Increasing the length of floating slab can effectively reduce natural frequency, while the range of frequency variation caused by the thickness of floating slab is relatively small. The length and thickness of floating slab can be properly adjusted to avoid the track resonance. (2) It is more integrated for the rail and floating slab through increasing the vertical stiffness of fastener, which increases the vibration frequency of the track structure. There is little effect on the vibration characteristics of SSFST for changing the installation spacing of steel springs. (3) It is more obvious for resonance to occur between the inner rail and floating slab at 116 Hz, 130 Hz and 161 Hz, and the track vibration mode shows multi-step reverse vibration on both sides and overall vertical bending vibration. (4) Due to the unbalance load caused by curve superelevation, the inner wheel weight plays the restraining role, which makes the inner rail and floating slab have various forms of bending deformation in a certain frequency range, increasing the complexity of the bending deformation of the track structure.
Multimorbidity and Its Associations With Anxiety and Depression Among Newly Diagnosed Patients With Breast Cancer: A Retrospective Observational Cohort Study in a US Commercially Insured and Medicare Advantage Population
Authors: Dai Dingwei , Coetzer Henriette , Zion Sean R. , Malecki Michael J. 
Published: November 2022

Background Multimorbidity is common in patients with breast cancer, thus increasing the complexity of cancer care and economic burden, worsening their prognosis and quality of life. The prevalence of multimorbidity and its influence on psychological distress among patients with breast cancer have not been well characterized. Objectives To examine the prevalence of multimorbidity and its associations with anxiety and depression among newly diagnosed patients with breast cancer. Methods We conducted a retrospective observational cohort study using a large administrative claims database. Patients with breast cancer (ICD-10-CM: C50.x) were identified during the study period (1/1/2017-12/31/2020). The index date was defined as the diagnosis date of breast cancer. Demographics and comorbid conditions were assessed using data within 12 months prior to the index date. Multimorbidity was defined as the presence of ≥2 comorbid conditions. Anxiety and depression were examined using data within 12 months after the index date. Multivariable logistic regressions were performed to examine the associations between multimorbidity and anxiety and depression, adjusting for sociodemographic factors. Results Of the 6392 patients with newly diagnosed breast cancer, 86.9% had multimorbidity at the time of breast cancer diagnosis. The median number of comorbid conditions was 5. Overall, 27.7% experienced anxiety, and 21.9% experienced depression in the first year following breast cancer diagnosis. An increased number of comorbid conditions was associated with elevated prevalence of both anxiety and depression. After adjusting for possible confounding factors, number of comorbid conditions was significantly associated with risk of anxiety (adjusted odds ratio [95% confidence interval (CI)]: 1.17 [1.15-1.19]), and depression (1.24 [1.21-1.26]); all P < .0001. Conclusions Multimorbidity was highly prevalent among patients with breast cancer and was strongly associated with increased risk of anxiety and depression in the first year following breast cancer diagnosis. The presence of multimorbidity, anxiety, and depression should be considered in the context of clinical decision making to optimize cancer care and improve mental health and quality of life.
A convex-deformable sandwich panel for mobile devices
Authors: Jeong Yoon Chang , Park Eun-Byeol , Kang Kiju 
Published: November 2022

Panels with monolithic auxetic micro-architectures are capable of bending into convex shapes. However, the thickness of panels with these micro-architectures (such as re-entrant trusses) is currently under a few millimeters; thus, they are too compliant for structural applications. Moreover, their interior spaces are commonly divided into very small cells to accommodate solid parts. Therefore, a novel sandwich panel composed of stainless steel face sheets with a two-dimensional auxetic pattern and a 3D-printed polymer truss core is proposed as a kinematically and statically determinate structure. This structure allows for a three-dimensional convex deformation under buckling and bending loads. The sandwich panel exhibits high structural robustness and can accommodate thick solid parts within the core. Even when packed with irregular solid chips in the core, a square panel with a 100 mm side length and 4 mm thickness can be deformed up to a minimum curvature of 83.3 mm under extreme five-point bending. Thus, this panel is expected to be used as the main structure for mobile devices, designed for convenient carrying in typical jean’s back and thigh pockets.
EDP-514 in healthy subjects and nucleos(t)ide reverse transcriptase inhibitor-suppressed patients with chronic hepatitis B
Authors: Feld Jordan J , Lawitz Eric , Nguyen Tuan , Lalezari Jacob , Hassanein Tarek , Martin Paul , Han Steven-Huy , Dieterich Douglas , Giard Jeanne-Marie , De La Rosa Guy , Ahmad Alaa , Luo Ed , Conery Annie L , Adda Nathalie 
Published: November 2022

Background Chronic hepatitis B (CHB) remains a major cause of morbidity and mortality. EDP-514 is a potent core inhibitor of hepatitis B virus (HBV) that reduces viral load reduction in HBV-infected chimeric mice. This first-in-human study evaluated the safety, tolerability, and pharmacokinetics (PK) of EDP-514 in healthy subjects and antiviral activity in patients with CHB. Methods In Part 1, 82 subjects received placebo or EDP-514 in fed or fasted state as single ascending doses of 50–800 mg and multiple ascending doses of 200–800 mg for 14 days. In Part 2, 24 HBV DNA-suppressed, nucleos(t)ide (NUC)-treated (i.e., NUC-suppressed) CHB patients received EDP-514 200–800 mg or placebo for 28 days. Results EDP-514 was well tolerated in healthy subjects and CHB patients with most adverse events of mild intensity. In Part 1, EDP-514 exposure increased in an approximately dose proportional manner up to 600 mg after single doses and up to 400 mg after 14-day dosing. In Part 2, EDP-514 exposure increased linearly with dose on Day 1 and Day 28, with some accumulation for Day 28 and median trough concentrations (Ctrough) approximately 20-fold above the protein-adjusted 50% effective concentration (EC50) for the dose range. Mean change in HBV RNA from baseline to Day 28 was −2.03, −1.67, −1.87, and −0.58 log U/mL in the 200 mg, 400 mg, 800 mg, and placebo CHB groups, respectively. Conclusions EDP-514 was well tolerated, had a PK profile supporting once daily dosing, and reduced HBV RNA levels in NUC-suppressed CHB patients.
Total Percutaneous Endovascular Aortic Arch Repair With a Triple Inner-Branch Device (the Innominate Approach)
Authors: Leone Nicola , Bieliauskas Gintautas , Ohrlander Tomas , Resch Timothy 
Published: November 2022

Purpose: To describe a completely percutaneous approach for endovascular arch repair (arch–percutaneous endovascular aortic repair [PEVAR]) with a triple inner-branch device: the “Innominate Approach.” Technique: After right axillary and single common femoral arteries percutaneous access, the arch stent-graft is introduced and deployed transfemorally using fusion overlay. The brachiocephalic artery (BCA) and the corresponding inner branch are cannulated from the axillary access. Through this access, a steerable-sheath guides antegrade cannulation of the left common carotid artery (LCCA) through its inner branch. Optionally, a wire preloaded through the left subclavian artery (LSA) and the LCCA branch, is snared from the BCA access providing LCCA through and through access. A 10 Fr sheath is then positioned from the BCA branch in the LCCA branch and a second, trans-axillary wire through the same sheath is used to catheterize the LCCA. The LCCA is then stented antegradely (regardless of approach). Finally, the BCA and LSA are bridged to complete the procedure. An additional novelty described is the use of VBX (W. L. Gore) as a bridging stent for the BCA. Conclusion: Arch-PEVAR is feasible with the use of adjuncts that are well-known for physicians performing complex endovascular repair. The “Innominate Approach” avoids access and exposure of the carotid arteries. Clinical Impact We aim to describe the feasibility of the axillary artery as the main route to perform the brachiocephalic artery (BCA) and the left common carotid artery bridging stenting in case of arch endovascular repair (arch-EVAR) with a triple Inner-Branch Device. According to the present “Innominate Approach”, percutaneous arch-EVAR is feasible using either a steerable sheath or a preloaded through-&-through wire. The Innominate approach, including a VBX bridging stent for the BCA, avoids carotid access and exposure, reduces the number of vascular accesses, and allows the downsizing of the trans-axillary devices.
Subcostal versus right lateral ultrasound measurements of inferior vena cava: Measurements obtained from these two views are not equivalent in non-ICU patients
Authors: Haroun Fadi , Robinson Mercedes , Shayman Corey S , Cotton Jennifer 
Published: November 2022

Objective: The objective of this study is to assess concordance between the subcostal and right lateral view for ultrasonographic inferior vena cava measurements including the end-inspiratory diameter, end-expiratory diameter and respiratory variation represented by the caval index in spontaneously breathing healthy adults. Methods: We recruited a convenience sample of 33 healthy adults. A phased array ultrasound probe was used to obtain inferior vena cava measurements from a subcostal view in the sagittal plane and from a right lateral view in the coronal plane with B-mode ultrasound. End-inspiratory diameter, end-expiratory diameter and caval index were obtained for each view. A two-tailed t-test was performed to compare the caval indices obtained by the two views. Bland–Altman analysis was used to obtain the limits of agreement for the inferior vena cava diameter and caval index across the two views. Results: Subcostal and right lateral caval indices across all participants were significantly different according to a paired t-test ( p < 0.0001). The Bland–Altman analysis showed wide limits of agreement in end-inspiratory diameter (−0.97 and 0.50 cm) and in end-expiratory diameter (−0.94 and 0.90 cm). The right lateral view underestimated the inferior vena cava caval index relative to the subcostal view. Conclusions: The subcostal and right lateral views are not equivalent in obtaining inferior vena cava measurements in spontaneously breathing healthy adults. Current cut-off values for measurement-based applications of inferior vena cava ultrasound, including fluid responsiveness using caval indices, may not be accurate when values are obtained from the right lateral view in the coronal plane of the inferior vena cava in patients.
Australian sonographers’ perceptions of patient safety in ultrasound imaging: Part two – translation into practice
Authors: McInerney John , Lombardo Paul , Cowling Cynthia , Roberts Simone , Sim Jenny 
Published: November 2022

Introduction: A lack of patient safety research hampers capacity to improve safety in healthcare. Ultrasound is often considered ‘safe’ as it does not use ionising radiation, a simplistic view of patient safety. Understanding sonographers’ actions towards patient safety is crucial; however, self-reported measures cannot always predict behaviour. This study is part of a PhD exploring patient safety in medical diagnostic ultrasound. The aim of this paper is to explore sonographers’ responses to the patient safety concerns identified in Part one of this study. The ultimate aim of the study is to inform the final phase of the doctoral study which will consider the next steps in improving the quality and safety of healthcare experienced by patients. Methods: A qualitative study using semi-structured, one-on-one interviews. The Theory of Planned Behaviour (TPB) explained how sonographers respond to perceived patient safety risks in practice. Results: Thirty-one sonographers were interviewed. Based on the seven themes identified in Part one of the study, results showed that incongruences exist between identifying patient safety risks and the actions taken in practice to manage these risks. Conclusion: The TPB showed that behavioural, normative and control beliefs impact sonographers’ responses to perceived patient safety risks in practice and can lead to risk avoidance. Lack of regulation in ultrasound creates a challenge in dealing with Fitness to Practice issues. Collective actions are required to support sonographers in taking appropriate actions to enhance patient safety from multiple stakeholders including accreditation bodies, regulatory authorities, educational institutions and employers.
Reduced shoulder proprioception due to fatigue after repeated handball throws and evaluation of test–retest reliability of a clinical shoulder joint position test
Authors: Sutton Peter , Lund Ohlsson Marie , Röijezon Ulrik 
Published: November 2022

Background Proprioception is vital for motor control and can be disturbed, for example, due to fatigue or injury. Clinical feasible, reliable and valid tests of shoulder proprioception are warranted. The aim was to investigate the effects of local fatigue on shoulder proprioception and the reliability of a feasible joint position sense test using an experimental repeated measures design. Method Forty participants repeated a shoulder joint position sense test to assess test–retest reliability. The test was then utilized on a subgroup of handball players who were subjected to five bouts of a repeated throwing task with the dominant hand. The effect of local fatigue was investigated by comparing the fatigued with the non-fatigued shoulder. Results There was a significant interaction for the arm × bout ( p = 0.028, ηp2 = 0.20) and a significant effect for the arm ( p = 0.034, ηp2 = 0.35) with a significant decrease in joint position sense for the throwing arm compared to the non-throwing arm. The intraclass correlation coefficient was 0.78 (95% CI = [0.57; 0.89]). The standard error of measurement between trials was 0.70° (range: 0.57°–0.90°). Discussion The results indicate that repeated throwing to fatigue disturbs shoulder joint position sense. Assessment with the modified test showed acceptable reliability and can be a valuable assessment tool in the clinic.
Skull base infections, their complications, and management
Authors: Nguyen Phat Tan , Chang Jennifer , Shahlaie Kiarash , Raslan Osama , Ozturk Arzu , Bobinski Matthew , Assadsangabi Reza 
Published: November 2022

Objective Our review aims to summarize the current literature on skull base infections (SBIs) and retrospectively analyze any such cases encountered at our institution. Design A literature search was conducted using online databases PubMed, MEDLINE, and ResearchGate with the terms “skull base osteomyelitis,” “temporal bone osteomyelitis,” “skull base infections,” “necrotizing otitis media,” and “SBO”. References from the resulting manuscripts were reviewed for relevant articles. A search of our electronic health records using the same key terms was also performed to identify patients with a tissue biopsy-confirmed diagnosis of skull base infections. Patients with an indeterminate diagnosis or inaccessible/poor imaging were excluded. Setting A level one trauma and major tertiary academic medical center. Participants All patients treated at the University of California Davis Health System with a confirmed diagnosis of skull base infections from January 2005 to November 2020. Main Outcome Measures Imaging results, symptoms, treatment, morbidity, and mortality. Results Our literature search yielded 59 articles ranging from 1982 to 2021. A retrospective search of our electronic health records identified two cases of skull base infections. Conclusion Skull base infections have no pathognomonic findings. A multimodal approach with computed tomography (CT), magnetic resonance imaging (MRI), and nuclear medicine is necessary to characterize the disease process in addition to a biopsy for definitive diagnosis. Other diagnoses can mimic SBI on imaging, such as nasopharyngeal carcinoma and inflammatory pseudotumor. Culture-guided antimicrobial treatment and surgery are mainstay therapies. Other adjuvant strategies currently lack the robust evidence necessary to characterize their risks and benefits.
Quality assessment of smartphone fitness apps used to increase physical activity level and improve general health in adults: A systematic review
Authors: Negreiros Alexandher , Maciel Roberto B T , Carvalho de Barros Bianca , Padula Rosimeire Simprini 
Published: November 2022

Introduction Mobile exercise apps for smartphones have been used with intervention measures to increase physical activity. This study aimed to identify and evaluate the quality of fitness apps for smartphones that were used to increase the level of physical activity and improve the overall health of healthy adults. Methods The systematic review was performed in five electronic databases EMBASE, MEDLINE, CINAHL, Academic Research Premier e Cochrane Reviews, and Trials. The search terms were grouped into three categories according to the principles of population, intervention, comparison, and outcomes. The following includes examples of the group terms: population (healthy adults), intervention (smartphone apps), and outcomes (physical activity level). Results Of the 3924 potential articles, 74 were read for full-text analysis. Only seven studies were included in the review. The methodological evaluation of the studies and the apps’ quality showed that only one study and one app were evaluated with good quality. All studies used a type of application to improve the level of physical activity (measured by the number of daily steps), reporting an increase and improvement in some general health indices (calorie expenditure, weight, BMI) in healthy adults, regardless of frequency and duration of intervention and applications. Conclusion We cannot say that the use of smartphone applications improves the level of physical activity and general health. The low methodological quality of the studies and the possibility to evaluate the applications used (Mars Scale) due to the lack of technical standardization presented in the studies, despite the app used showing positive results in all studies.