bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are group identity and sense of belonging relevant for group pain management programmes? An exploratory pilot study
Authors: Wilson Dianne , Mackintosh Shylie , Nicholas Michael K , Moseley G Lorimer , Costa Daniel , Ashton-James Claire 
Published: June 2022

Introduction Cognitive Behaviour Therapy (CBT)–based programmes for chronic pain are often conducted in groups, most likely for time and cost efficiencies. However, there has been very little investigation of the role that the group itself, and particularly the processes occurring within the group, may play in individual outcomes. The objective of this study was to explore whether social group processes were relevant to key treatment outcomes of group CBT for chronic pain. Method Data were collected from 15 groups (N = 118) undertaking a pain management programme in a tertiary setting. Intraclass correlations were computed to determine any clustering of outcomes in groups, and linear mixed modelling analysis explored pre-registered hypotheses of associations between treatment outcomes and the social group processes of Group Identification and Sense of Belonging. Results A weak association between early identification with the group and changes in pain-related disability was shown. In addition, an enhanced global Sense of Belonging was associated with increased pain self-efficacy. Conclusion These associations, in a programme that had not been designed to address group processes, suggest that their relevance is worth further investigation, particularly in group programmes that do focus on the social consequences of chronic pain. Future studies should investigate whether manipulation of social group processes within a CBT-based pain programme enhances pain-related outcomes and improves the overall well-being of people with chronic pain.
The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee
Authors: Campo Elias , Jaffe Elaine S. , Cook James R. , Quintanilla-Martinez Leticia , Swerdlow Steven H. , Anderson Kenneth C. , Brousset Pierre , Cerroni Lorenzo , de Leval Laurence , Dirnhofer Stefan , Dogan Ahmet , Feldman Andrew L. , Fend Falko , Friedberg Jonathan W. , Gaulard Philippe , Ghia Paolo , Horwitz Steven M. , King Rebecca L. , Salles Gilles , San-Miguel Jesus , Seymour John F. , Treon Steven P. , Vose Julie M. , Zucca Emanuele , Advani Ranjana , Ansell Stephen , Au Wing-Yan , Barrionuevo Carlos , Bergsagel Leif , Chan Wing C. , Cohen Jeffrey I. , d’Amore Francesco , Davies Andrew , Falini Brunangelo , Ghobrial Irene M. , Goodlad John R. , Gribben John G. , Hsi Eric D. , Kahl Brad S. , Kim Won-Seog , Kumar Shaji , LaCasce Ann S. , Laurent Camille , Lenz Georg , Leonard John P. , Link Michael P. , Lopez-Guillermo Armando , Mateos Maria Victoria , Macintyre Elizabeth , Melnick Ari M. , Morschhauser Franck , Nakamura Shigeo , Narbaitz Marina , Pavlovsky Astrid , Pileri Stefano A. , Piris Miguel , Pro Barbara , Rajkumar Vincent , Rosen Steven T. , Sander Birgitta , Sehn Laurie , Shipp Margaret A. , Smith Sonali M. , Staudt Louis M. , Thieblemont Catherine , Tousseyn Thomas , Wilson Wyndham H. , Yoshino Tadashi , Zinzani Pier-Luigi , Dreyling Martin , Scott David W. , Winter Jane N. , Zelenetz Andrew D. 
Published: June 2022

AbstractSince the publication of the Revised European-American Classification of Lymphoid Neoplasms in 1994, subsequent updates of the classification of lymphoid neoplasms have been generated through iterative international efforts to achieve broad consensus among hematopathologists, geneticists, molecular scientists, and clinicians. Significant progress has recently been made in the characterization of malignancies of the immune system, with many new insights provided by genomic studies. They have led to this proposal. We have followed the same process that was successfully used for the third and fourth editions of the World Health Organization Classification of Hematologic Neoplasms. The definition, recommended studies, and criteria for the diagnosis of many entities have been extensively refined. Some categories considered provisional have now been upgraded to definite entities. Terminology for some diseases has been revised to adapt nomenclature to the current knowledge of their biology, but these modifications have been restricted to well-justified situations. Major findings from recent genomic studies have impacted the conceptual framework and diagnostic criteria for many disease entities. These changes will have an impact on optimal clinical management. The conclusions of this work are summarized in this report as the proposed International Consensus Classification of mature lymphoid, histiocytic, and dendritic cell tumors.
Clinical care pathway for the evaluation of patients with suspected VITT after ChAdOx1 nCoV-19 vaccination
Authors: Lee Agnes Y. Y. , Al Moosawi Muntadhar , Peterson Erica A. , McCracken Rita K. , Wong Steven K. W. , Nicolson Hamish , Chan Vicky , Smith Tyler , Wong Michelle P. , Lee Lauren J. , Griffiths Cameron , Rahal Bhavdeep , Parkin Stephen , Afra Kevin , Ambler Kimberley , Chen Luke Y. C. , Field Thalia S. , Lindsay Heather C. , Lavoie Martin , Li Charles , Migneault David , Naus Monika , Piszczek Jolanta , Rahmani Poupak , Sreenivasan Gayatri , Wan Tony , Yee Adrian , Zypchen Leslie , Sweet David 
Published: June 2022

Abstract
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare complication after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) adenoviral vector vaccination. In British Columbia (BC), Canada, a provincial clinical care pathway was developed to guide clinicians in evaluating for VITT among patients who present with thrombocytopenia or thrombosis symptoms within 4 to 28 days after adenoviral vector vaccine exposure. All patients had enzyme-linked immunosorbent assay (ELISA) testing for platelet factor 4 (PF4) antibodies, and all cases with positive PF4-ELISA or d-dimer levels ≥2.0 mg/L fibrinogen equivalent units (FEU) had further testing for platelet-activating PF4 antibodies using a modified serotonin release assay (SRA). Between 1 May and 30 June 2021, 37% of 68 patients investigated for VITT had thrombosis, but only 3 had VITT confirmed by PF4-ELISA and SRA. Platelet counts, d-dimer levels, and ELISA optical density values were significantly different between those with and without VITT. Three patients had thrombocytopenia and thrombosis with d-dimer levels &gt;4.0 mg/L FEU but had negative PF4-ELISA and SRA results. Patients with VITT were treated successfully with IV immunoglobulin, nonheparin anticoagulants, and corticosteroids. Our pathway demonstrated that thrombosis is common among patients investigated for VITT and that PF4-ELISA testing is necessary to confirm VITT in those presenting with thrombosis and thrombocytopenia.
Study on the Distribution of Frictional Forces on Z-yarn Continuous Implanted Preforms and Their Applications
Authors: Guo Zitong , Shan Zhongde , Huang Jihua , Xue Debo 
Published: June 2022

AbstractTo improve the quality and efficiency of Z-directional 3D preform forming, the Z-yarn frictional force distribution model of the preform and its wear mechanism were investigated. In this study, a tensile force measuring device was designed to measure the force required to replace the guide sleeve, which is equivalent to the Z-yarn frictional forces. The frictional force is proportional to the number of preform layers and is applied to the preform decreased from the corner, edge, sub-edge, and middle in order. A back propagation neural network model was established to predict the friction at different positions of the preform with different layers, and the error was within 1.9%. The wear of Z-yarn was studied at different frictional positions and after different times of successive implantation into the preform. The results showed that with an increase in the number of Z-yarn implantations and frictional forces, the amount of carbon fiber bundle hairiness gradually increased, and the tensile fracture strength damage of the fiber was increasingly affected by the frictional forces. In the corner position of the preform, when the number of implantations was 25, the fiber fracture strength decreased non-linearly and substantially; in order to avoid fiber fracturing in the implantation process, the Z-yarn needs to be replaced in time after 20–25 cycles of continuous implantation. This study solves the problem of difficulty in measuring the force required for individual replacements owing to the excessive number of guide sleeves, puts forward the relationship between fiber wear, preform position, and implantation times, solves the phenomenon of fracture in the preform during Z-direction fiber implantation, and realizes the continuous implantation of fibers.
Clinical and behavioural features of SYNGAP1-related intellectual disability: a parent and caregiver description
Authors: Wright Damien , Kenny Aisling , Eley Sarah , McKechanie Andrew G. , Stanfield Andrew C. 
Published: June 2022

Abstract
Background
SYNGAP1-related intellectual disability (ID) is a recently described neurodevelopmental disorder that is caused by pathogenic variation in the SYNGAP1 gene. To date, the behavioural characteristics of this disorder have mainly been highlighted via the prevalence of existing diagnoses in case series. We set out to detail the behavioural features of this disorder by undertaking interviews with those who have a child with SYNGAP1-related ID to allow them to describe their child’s behaviour.

Methods
We conducted 27 semi-structured interviews with parents and caregivers which covered basic information (e.g., age, gender), family history, perinatal history, past medical history, developmental history, epilepsy, behavioural history, and a general description of their child’s behaviour.

Results
Using a mixed quantitative and qualitative approach, the responses from the parents indicated that those with SYNGAP1-related ID showed high rates of autism spectrum disorder (52%), difficulties with fine and gross motor skills, delays in language development, and a high prevalence of epilepsy (70%). A qualitative analysis highlighted their general behaviour affected the themes of daily living skills, distress-related behaviours, emotional regulation, difficulties with change, a lack of danger awareness, and sensory differences. Sensory features described involved auditory, visual, tactile, gustatory, and proprioceptive themes.

Conclusions
Our findings and behavioural descriptions provide important insights as well as implications for the diagnosis and care of those with SYNGAP1-related ID.
Measuring spatial accessibility to urban services for older adults: an application to healthcare facilities in Milan
Authors: Guida Carmen , Carpentieri Gerardo , Masoumi Houshmand 
Published: June 2022

AbstractThis study proposes a Geographic Information Systems-based methodology to measure accessibility to urban services from the elderly perspective to support urban planning processes. Specifically, it seeks to understand and clarify how the urban environment can influence the quality of life for older adults, mostly through pedestrian and public transport networks, locations of essential urban services, and the organisation of their resources. In light of a significant demographic change, policymakers will have to promote age-friendly urban planning approaches to guarantee equal access to services and activities. We propose a methodology to measure accessibility to healthcare provision services that considers land-use and mobility features and older adults' behavioural traits. The method belongs to the family of 2SFCA—2 steps floating catchment area—which evaluate accessibility as the combination of both supply and demand of urban services. Therefore, we have introduced innovative elements to shape actual mobility opportunities for the elderly and their travel choices. The methodology was applied to Milan's city to measure accessibility to the Health Protection Agency (ATS) services, which is responsible for healthcare assistance to the elderly dwelling in the city. The outputs show that a significant share of older people (almost 40%) suffer from poor accessibility to primary health services and that they mostly live in the city periphery. Moreover, the application to a case study has shown that the methodology could identify the critical aspects needed to aid urban planning to achieve a high quality of life for elderly people.
TP53 and TP53-associated genes are correlated with the prognosis of paediatric neuroblastoma
Authors: Wang Haiwei , Wang Xinrui , Xu Liangpu , Zhang Ji 
Published: June 2022

Abstract
Background
TP53 is rarely mutated in paediatric neuroblastoma. The prognosis of TP53 and TP53-associated genes in paediatric neuroblastoma is unclear. The objectives of the study were to analyse datasets of 2477 paediatric neuroblastoma patients from eight independent cohorts to reveal the prognosis of TP53 and TP53-associated genes.

Results
High TP53 mRNA expression was associated with shortened event-free survival and overall survival in paediatric neuroblastoma. Moreover, a higher enrichment score of the TP53 signalling pathway was associated with worse clinical outcomes of paediatric neuroblastoma. Among the genes associated with TP53, CCNE1, CDK2 and CHEK2 were correlated with unfavourable clinical outcomes, while SESN1 was correlated with favourable clinical outcomes of paediatric neuroblastoma in the eight independent neuroblastoma cohorts. TP53, CCNE1, CDK2 and CHEK2 were overexpressed in neuroblastoma patients with MYCN amplification, while SESN1 was downregulated in neuroblastoma patients with MYCN amplification. CCNE1, SESN1, MYCN amplification and age at diagnosis were independent prognostic markers of neuroblastoma. CCNE1 was also highly expressed in paediatric neuroblastoma patients with an age at diagnosis ≥ 18 months, while SESN1 was downregulated in paediatric neuroblastoma patients with an age at diagnosis ≥ 18 months. Combinations of CCNE1 with age at diagnosis or combinations of SESN1 with age at diagnosis achieved superior prognostic effects in paediatric neuroblastoma. Finally, we constructed a nomogram risk model of paediatric neuroblastoma based on age and TP53, CCNE1, CDK2, CHEK2 and SESN1 expression. The nomogram model could predict the overall survival of paediatric neuroblastoma and MYCN nonamplified paediatric neuroblastoma with high specificity and sensitivity.

Conclusions
TP53 and TP53-associated genes CCNE1, CDK2, CHEK2 and SESN1 were significantly associated with the clinical outcomes of paediatric neuroblastoma.
Abstract screening using the automated tool Rayyan: results of effectiveness in three diagnostic test accuracy systematic reviews
Authors: Valizadeh Amir , Moassefi Mana , Nakhostin-Ansari Amin , Hosseini Asl Seyed Hossein , Saghab Torbati Mehrnush , Aghajani Reyhaneh , Maleki Ghorbani Zahra , Faghani Shahriar 
Published: June 2022

Abstract
Objective
To evaluate the performance of the automated abstract screening tool Rayyan.

Methods
The records obtained from the search for three systematic reviews were manually screened in four stages. At the end of each stage, Rayyan was used to predict the eligibility score for the remaining records. At two different thresholds (≤2.5 and < 2.5 for exclusion of a record) Rayyan-generated ratings were compared with the decisions made by human reviewers in the manual screening process and the tool’s accuracy metrics were calculated.

Results
Two thousand fifty-four records were screened manually, of which 379 were judged to be eligible for full-text assessment, and 112 were eventually included in the final review. For finding records eligible for full-text assessment, at the threshold of < 2.5 for exclusion, Rayyan managed to achieve sensitivity values of 97-99% with specificity values of 19-58%, while at the threshold of ≤2.5 for exclusion it had a specificity of 100% with sensitivity values of 1-29%. For the task of finding eligible reports for inclusion in the final review, almost similar results were obtained.

Discussion
At the threshold of < 2.5 for exclusion, Rayyan managed to be a reliable tool for excluding ineligible records, but it was not much reliable for finding eligible records. We emphasize that this study was conducted on diagnostic test accuracy reviews, which are more difficult to screen due to inconsistent terminology.
A survey of knowledge, attitudes, barriers and support needs in providing hepatitis B care among GPs practising in Australia
Authors: Xiao Yinzong , van Gemert Caroline , Howell Jess , Wallace Jack , Richmond Jacqueline , Adamson Emily , Thompson Alexander , Hellard Margaret 
Published: June 2022

Abstract
Background
In Australia, only 22% of people with chronic hepatitis B (CHB) are clinically managed; and a national effort is engaging primary care workforce in providing CHB-related care. This study explored CHB-related knowledge, attitudes, barriers and support needs of general practitioners (GPs).

Methods
A survey was sent to a random sample of 1,000 Australian GPs in April- October 2018; 134 of 978 eligible GPs completed the questionnaire (14%).

Results
Respondents had high knowledge of at-risk populations (> 79%) and hepatitis B serology (82%), and most saw hepatitis B testing and monitoring as part of their work (95% and 86%, respectively). However, the survey revealed low knowledge, awareness and intention with respect to hepatitis B treatment: 23% correctly understood treatment initiation; 40% were aware that treatment for CHB could be dispensed in the community; 23% agreed that prescribing was part of their work. Lack of time was considered the greatest barrier (38%) and clear guidelines was the most important facilitator to providing care (72%).

Conclusion
Interventions are needed to generate interest and skills to provide CHB-related care by GPs.
A novel tool for predicting the risk of central lymph node metastasis in patients with papillary thyroid microcarcinoma: a retrospective cohort study
Authors: Luo Qian-wen , Gao Shan , Lv Xiao , Li Si-jia , Wang Bo-fang , Han Qing-qing , Wang Yun-peng , Guan Quan-lin , Gong Tao 
Published: June 2022

Abstract
Introduction
Central lymph node status in papillary thyroid microcarcinoma (PTMC) plays an important role in treatment decision-making clinically, however, it is not easy to predict central lymph node metastasis (CLNM). The present work focused on finding the more rational alternative for evaluating central lymph node status while identifying influencing factors to construct a model to predict CLNM incidence.

Methods
In this study, we retrospectively analyzed the typical sonographic and clinicopathologic features of 546 PTMC patients who underwent surgery, among which, the data of 382 patients were recruited in the training cohort and that of 164 patients in the validation cohort. Based on the outcome of the training cohort, significant influencing factors were further identified through univariate analysis and were considered as independent variables in multivariable logistic regression analysis and incorporated in and presented with a nomogram.

Results
In total, six independent predictors, including the age, sex, tumor size, multifocality, capsular invasion, Hashimotos thyroiditis were entered into the nomogram. Both internal validation and external validation revealed the favorable discrimination of our as-constructed nomogram. Calibration curves exhibited high consistency. As suggested by decision-curve analyses, the as-constructed nomogram might be applied in clinic. Besides, the model also distinguished patients according to risk stratification.

Conclusions
The novel nomogram containing remarkable influencing factors for CLNM cases was established in the present work. The nomogram can assist clinicians in clinical decision-making.
Association between sleep duration and albumin in US adults: a cross-sectional study of NHANES 2015–2018
Authors: Li Jingxian , Guo Lizhong 
Published: June 2022

Abstract
Background
Albumin has multiple functions and is used in the clinical assessment of liver function, kidney function and nutritional status. However, few epidemiological studies have evaluated the association between sleep duration and albumin. Therefore, we carried out a cross-sectional study to address this issue. The aim of the study was to investigate the association between sleep duration and albumin in American adults based on the NHANES (National Health and Nutrition Examination Survey).

Methods
A total of 9,973 participants aged $$\ge$$
≥
20 years were included in this study from NHANES 2015–2018. Weighted data were calculated according to analytical guidelines. Linear regression models and smooth curve fitting were used to assess and describe the relationship between sleep duration and albumin. The inflection point was determined by a two-step recursive method. Moreover, univariate and stratified analyses were performed.

Results
There was an inverted U-shaped association between sleep duration and albumin levels. Albumin levels were highest when the sleep duration was 7.5 h. Compared to 7–8 h of sleep, short sleep duration was linked to lower albumin levels [sleep duration $$\le$$
≤
5 h: β $$=$$
=
-1.00, 95% CI (-1.26, -0.74), P < 0.0001]. Compared to 7–8 h of sleep, long sleep duration was related to lower albumin levels [sleep duration $$>$$
>
9 h: β $$=$$
=
-0.48, 95% CI (-0.68, -0.27), P < 0.0001].

Conclusions
Sleep duration had an inverted U-shaped relationship with albumin, with short or long sleep duration associated with significantly lower albumin levels.
A retrospective analysis of risk factors for massive hemoptysis in patients with bronchiectasis
Authors: Luo Ling , Luo Jing , Jiang Yu 
Published: June 2022

Abstract
Background
Massive hemoptysis is a common and fatal complication of bronchiectasis. However, the risk factors for massive hemoptysis in patients with bronchiectasis have not yet been reported. This study investigated the potential risk factors for massive hemoptysis in patients with bronchiectasis.

Methods
This retrospective study included patients with bronchiectasis and their data were obtained from medical records. The risk factors for massive hemoptysis were evaluated by multivariate analysis of patient characteristics, medical history, and computed tomography imaging data, including the number of lesions, lesion location, and laboratory findings.

Results
Among 379 patients, 61 (16.09%) experienced severe hemoptysis. Multivariate analysis revealed that diabetes (odds ratio (OR) 2.885; 95% confidence interval (CI) 1.009–8.247), lesions involving two lobes (OR 4.347; 95% CI 1.960–9.638) and three lobes (OR 2.787; 95% CI 1.055–7.363) were significant predictors of severe hemoptysis. However, a disease course between 1 and 5 years (OR 0.300; 95% CI 0.112–0.801) and involvement of the left lower lobe (OR 0.394; 95% CI 0.196–0.793) were protective factors for the prevention of massive hemoptysis. Lesions in the right upper lobe were more likely to cause massive hemoptysis (OR 1.458) than involvement of other lobes.

Conclusions
Diabetes and lesions involving two and three lobes, were risk factors for massive hemoptysis in patients with bronchiectasis. Disease duration between 1 and 5 years and involvement of the left lower lobe were protective factors, while lesions in the right upper lobe had a stronger relationship with massive hemoptysis in patients with bronchiectasis.