bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microscopic investigation of the influence of complex stress states on internal erosion and its impacts on critical hydraulic gradients
Authors: Zhou Chuang , Qian Jian‐Gu , Yin Zhen‐Yu 
Published: October 2022

AbstractInternal erosion involves the loss of fine particles within the matrix of coarse particles under seepage flow, posing a severe threat to hydraulic structures. This paper focuses on internal erosion considering anisotropic stress conditions. The influence of the anisotropic stress state, represented by vertical stress equal to, bigger than, or smaller than horizontal stress, was investigated using coupled computational fluid dynamics (CFD) and the discrete element method (DEM). Results show that the loss of fine particle specimens under anisotropic stress conditions is greater than that for samples under isotropic stress states, as the loss of fine particles leads to an evolution of anisotropy into isotropy, with local contact force chains gradually forming spatially isotropic structures. The strong force chains of specimens under triaxial compression were also found to develop a dominant orientation in the vertical direction, leading to clogging in the upward migration of fine particles and increasing the critical hydraulic gradient. In addition, the evolution of void ratio, hydraulic drag force, connectivity, and coordination number has also been analyzed to exhibit the influence of stress anisotropy on internal erosion.
Determinants of missed nursing care in Jordanian hospitals during COVID‐19 pandemic
Authors: Khrais Huthaifah , Alsadi Mohammad , Oweidat Islam , Ahmad Muayyad 
Published: October 2022

AbstractAimThe aim of the study was to examine the effect of perceived organizational support, accountability and nurses' characteristics on missed nursing care under the impact of COVID‐19.DesignA cross‐sectional design was used to describe and predict nurses' characteristics.MethodsA sample of 536 Registered Nurses participated in the study from eight hospitals in different health sectors in Jordan (three public hospitals, three private hospitals and two teaching hospitals).ResultsCommunication problems had the highest impact on missed nursing care, compared with labour resources and material resources reasons. Higher patient: nurse ratio aggravated by COVID‐19 pandemic, years of experience, satisfaction with the income, perception of accountability and organizational support were among the factors associated with the levels of missed nursing care.
Relationship between gonial angle and articular disk position of the temporomandibular joints: A retrospective study
Authors: Muraoka Hirotaka , Hirahara Naohisa , Tokunaga Satoshi , Okada Shunya , Ichiki Shungo , Kondo Takumi , Kaneda Takashi 
Published: October 2022

AbstractPurposeMagnetic resonance imaging (MRI) is frequently used to diagnose temporomandibular joint disease. However, very few studies have assessed the relationship between the mandibular gonial angle and temporomandibular joint (TMJ) disorders using panoramic radiography and MRI. The aim of this study was to assess the relationship between the gonial angle and articular disk position of the TMJs using panoramic radiography and MRI.Material and methodThe patients underwent panoramic radiography and MRI simultaneously at a university hospital between April 2017 and March 2018. We analyzed the records of 109 patients with and without disc displacement. Among these, 88 patients had disc displacement of the TMJ, while 21 patients were normal. The variable “mean mandibular gonial angle” was evaluated as a predictor. The primary outcome was the presence or absence of disc displacement in the TMJs. The other variables included sex and age. Data were analyzed using Spearman's rank correlation coefficient, the Mann–Whitney U test, and receiver operating characteristic (ROC) curves. Statistical significance was set at P < 0.05.ResultsThere was no significant difference between men and women in mean gonial angle, and there was no correlation with age (P > 0.05). Moreover, the mean mandibular gonial angle in the disc displacement group was significantly higher than that in the nondisc displacement group (P < 0.01). ROC analysis revealed a cutoff mandibular gonial angle of 120.23° for predicting the development of disc displacement.ConclusionsMandibular gonial angle is a useful parameter for predicting disc displacement of the TMJs.
High frequency of heat shock protein 27 overexpression is a highly effective, high‐coverage marker for minimal residual disease detection in children with B‐cell acute lymphoblastic leukemia
Authors: Chou Shu‐Wei , Su Ying‐Hui , Lu Meng‐Yao , Chang Hsiu‐Hao , Yang Yung‐Li , Lin Dong‐Tsamn , Lin Kai‐Hsin , Coustan‐Smith Elaine , Jou Shiann‐Tarng 
Published: October 2022

AbstractBackgroundAcute lymphoblastic leukemia (ALL) is the most common pediatric cancer. Minimal residual disease (MRD) detection is the most powerful prognostic tool for monitoring treatment efficacy and predicting clinical outcomes. We aimed to identify key leukemia‐associated markers, the proportions of differential expression in patients, and the most effective marker combination for MRD detection by flow cytometry.MethodsBone marrow samples were collected from 132 pediatric patients with newly diagnosed (n = 115) or relapsed (n = 17) B‐cell precursor (BCP)‐ALL. We used CD19, CD10, CD34, CD45 as backbone markers to identify immature B cells and analyzed the differential expression of 18 leukemia‐associated markers using seven‐color multiparameter flow cytometry.ResultsLeukemic cells in all 132 patients expressed leukemia‐associated markers. The most commonly overexpressed marker was heat shock protein 27 (Hsp27) (108 patients, 81%), followed by CD73 (102 patients, 77%) and CD123 (80 patients, 60%). CD38 was underexpressed in 64 patients (48%). Hsp27 overexpression persisted in 50 out of 57 follow‐up MRD bone marrow samples (87%) and was associated with older age at diagnosis. Hsp27 overexpression was not associated with MRD levels or genetic abnormalities including hyperdiploidy, t(12;21)/ETV6‐RUNX1, t(1;19)/TCF3‐PBX1, t(9;22)/BCR‐ABL1, or 11q23/KMT2A rearrangements. Four remaining leukemia‐associated markers (Hsp27, CD73, CD58, CD24) after in silico deletion from the original panel could collectively detect leukemia‐associated cell profiles in 100% of cases in this cohort and 98% of cases in a validation cohort.ConclusionHsp27 combined with CD73, CD58, CD24, and backbone markers allows monitoring MRD in virtually all patients with BCP‐ALL.
Heat conduction joining with the multispot focusing lens
Authors: Halbhuber Cornelia 
Published: October 2022

AbstractDespite the rapid development of modern lasers, the Gaussian intensity distribution often leads to problems, especially in laser material processing. When welding wide weld seams, a top‐hat profile would often make much more sense in order to heat the weld seam as homogeneously as possible. In narrow curves, the different feed rates on the inside and outside of a wide weld seam result in further inhomogeneity. For this reason, a special optical system was developed that delivers homogeneous intensity distribution – both in straight lines and in narrow curves. The intensity distribution of a wide top‐hat profile can be changed locally and temporally by nine parallel beams. The welding head is installed on a robotic arm that travels along the weld seam and temperature homogeneity of >90 % within the spot can be achieved.
Lasers in plastic processing, a big impact in the industry
Authors: Castelo‐Porta Antonio 
Published: October 2022

AbstractPlastic materials continue to be of great importance for a large number of industries. Environmental regulations are moving towards the reduction and control of their presence in the market to avoid an increase in waste, but their properties have made them the preferred material for numerous applications. The use of lasers in industrial applications has been extended to the processing of this family of materials due to their advantages when cutting, marking, drilling or welding these components.
Development of thermoplastic recycled blends from biomedical waste: evaluation of properties and value addition thereof
Authors: Raghavan Ashish , Mohanty Smita , Biswal Manoranjan , Vardikar Himalaya S , G S Wasim Feroze , Nayak Sanjay K 
Published: October 2022

AbstractThe recycled polyolefin waste which included polypropylene (PP) and low‐density polyethylene (LDPE) were collected from hospital and subsequently sterilized by 1% sodium hypochlorite and followed by microwave disinfection. The sterilized BMW were analyzed for growth of pathogens if any. FTIR analysis was performed to analyze the composition of the waste as well as Carbonyl index to evaluate the extent of degradation post sterilization process. Recycled blends were prepared using melt extrusion technique and ethylene diene monomer was added to balance the interface between the varied polyolefin waste. Blends were studied for mechanical and morphological properties. Thermal analysis employed DSC revealed two different peaks of crystallization and melting revealing incompatibility in the blends. DMA showed reduction in the modulus with incorporation of LDPE and EPDM. SEM analysis confirmed the homogeneous distribution of RLD droplets with reduction in the interparticle distance indicates the partial miscibility. © 2022 Society of Industrial Chemistry.
Evaluation of thermal boundary conditions in floating photovoltaic systems
Authors: Amiot Baptiste , Le Berre Rémi , Giroux‐Julien Stéphanie 
Published: October 2022

AbstractReconciling the use of space and the production of low‐carbon electricity is a key challenge in the face of changing human needs. In this context, floating photovoltaics (FPV) is proving to be a key application to colocate energy production with several activities (hydroelectricity and aquaculture). A major benefit of FPV technologies is the reduced module temperature. However, the causes of this thermal observation are still unknown. The density of the distribution of the floaters and the thermal behavior of the waterbody are two postulated roots that show positive correlations with regard to the module temperature. Therefore, there is interest in identifying precise thermal features in the application because the yield surplus promised in FPV technology is based on this cooling effect. This research aims to understand the heat mechanisms that arise in this application in comparison with ground‐mounted photovoltaics (PV). A special framework based on 1‐D thermal modeling and statistical classification of the results by dimensionless related features is proposed. This strategy offers a possibility to differentiate the influence of the thermal modes separately over the module temperature. First, a gain of 20% to 50% in the convective transfers is demonstrated for FPV compared with ground‐mounted applications. Data exploitation associates these gains with the forced convective effects of the wind blowing on the front of the modules. Gains in free convective transfers are associated to the airflow around the module rear face, reducing the phenomenon of thermal buffering. The framework also demonstrates that the emissivity‐based correlations for the radiative boundaries are in good agreement with the radiative phenomena involved in FPV. When convection preferentially cools down the module, the participating media nearby acts as a heat source, warming the installation. Thus, understanding these mechanisms in the FPV application would provide opportunities for improved temperature management through floats or array‐scale optimizations.
Mechanically robust and rapidly degradable hydrogels for temporary water plugging in oilfields
Authors: Yuan Zhaoyang , Cao Zhenxing , Wu Rui , Xu Qiongjun , Xu Hu , Wu Haitao , Jin Biqiang , Wu Wenqiang , Zheng Jing , Wu Jinrong 
Published: October 2022

AbstractHydrogels have been widely used for in‐depth water control and water plugging in most mature oilfields; however, the poor mechanical properties as well as non‐degradable characteristics severely limit their applications. Herein, a multifunctional macromolecular cross‐linker (GA) based on a natural macromolecule, gelatin, is fabricated and used to prepare polyacrylamide hydrogels. Cross‐linking with GA leads to a special network involving physical entanglements that dissipate energy and topological cross‐links that distribute stress. Therefore, the hydrogels manifest remarkable mechanical strength, toughness and tear‐resistance. At the same time, GA can be readily degraded at high temperature, leading to disintegration of the hydrogels. The flow model in porous media reveals that the hydrogels present a significant ability of water plugging and rapid degradation, where the plugging ratio and degradation ratio reach 99% and 100%, respectively. Such mechanical properties and degradation performance enable the hydrogels to serve as a novel temporary water plugging agent for heterogeneous reservoirs of oilfield.
Selecting interventions for a psychosocial support program for prostate cancer patients undergoing active surveillance: A modified Delphi study
Authors: Donachie Kim , Adriaansen Marian , Nieuwboer Minke , Cornel Erik , Bakker Esther , Lechner Lilian 
Published: October 2022

AbstractObjectiveCurative treatment of low‐risk prostate cancer (LR‐PCa) does not improve cancer specific survival and active surveillance (AS) is recommended. Although AS is cost‐effective and reduces treatment‐related complications, it requires psychosocial support. Research on psychosocial interventions specifically focused on men undergoing AS is limited. Aim of this study is to reach consensus amongst relevant stakeholders on selecting interventions offering psychosocial support to PCa patients during AS.MethodsIn accordance with the RAND/UCLA method, a modified Delphi approach was used to establish consensus on selecting interventions. During phase one, interventions were identified through a literature review and open survey among all participants. During phase two, three consensus rounds were conducted to rate potential interventions and obtain statistical consensus. The IQ healthcare consensus tool was used to calculate statistical consensus.ResultsAfter the first consensus round, 31 participants scored individual interventions on relevance using a 9‐point Likert scale resulting in the selection of six interventions. During the second consensus round 13 discussion items were reviewed during a focus group. After the third consensus round, seven additional interventions were selected by 23 participants.ConclusionsIn total, 13 interventions were selected for inclusion in a support program. This included four interventions within the domain information and education, three within coping and support, one intervention within physical wellbeing and four within the domain lifestyle.
Should asymptomatic patients with congenital lung malformations undergo surgery? A decision analysis
Authors: Yang Weili , Gao Ya , Li Peng , Eckman Mark H. 
Published: October 2022

AbstractBackgroundCongenital lung malformations (CLMs) are being detected more frequently during pregnancy. There is controversy regarding the optimal treatment for an asymptomatic child with prenatally diagnosed CLMs. Due to the paucity of information from clinical trials, we developed decision analytic models to compare two treatment strategies for such patients—elective surgical resection versus expectant management.MethodsWe built decision analytic models stratified by lesion size. We used data from English language literature identified through PubMed searches along with estimates from expert opinions of surgical colleagues. We analyzed results for two hypothetical asymptomatic 6‐month‐old children with CLMs; one has a large lesion occupying more than 50% of the involved lobe, while the other has a small lesion occupying less than 50% of the involved lobe. We used quality‐adjusted life years (QALYs) to measure effectiveness.ResultsFor an asymptomatic child with a small or large lesion, expectant management resulted in a small gain of 0.09 or 0.15 QALYs, respectively. Sensitivity analyses showed that surgical resection would be preferred if the probability of remaining asymptomatic was low.ConclusionsIn contrast to current practice, expectant management may be a better alternative for asymptomatic children born with CLMs. More longitudinal studies are required to improve the accuracy of the model.
One (vis‐à‐vis Planetary, Eco) health: A landscape analysis of educational programs
Authors: Yasobant Sandul , Daptardar Monal , Kurup Karishma Krishna , Panwar Divya , Bongcac Marianne , Santos Mara Ysabella De Los , Guinto Renzo R. , Saxena Deepak , Tiwari Simmi 
Published: October 2022

AbstractTo sustain the health of humans, animals, and their shared environment, global advocacy in policy, funding, education, and training in multi‐actor, multi‐domain, and multi‐level collaboration is required. Emerging interdisciplinary concepts such as One Health, Planetary Health, and Eco‐Health (OH/PH/EH) have flagged opportunities to promote health across species; however, there is a lack of understanding about the extent and type of available education and training of professionals working in these disciplines. Therefore, this review aims to identify the ongoing efforts in the pedagogy of imparting OH/PH/EH education across the globe. We conducted a systematic Google database search between August and October 2021. The specific course types covered in this review were limited to degree programs and short courses. All courses using the terms “One Health,” “Planetary Health,” and “Eco health” were included. A descriptive analysis was conducted to understand the distribution of these courses based on the course type, geographic region, mode of delivery, duration, and course fees. A total of 61 courses delivered across the globe were identified in this review. Among these courses, there were three doctoral degrees, 31 master's degrees, two bachelor's degrees, and 25 short courses documented. The majority of the courses were related to OH (n = 43), followed by PH (n = 10), and EH (n = 08). Overall, there are still a limited number of courses or programs offered on OH/PH/EH, especially for PH and EH. There was geographic inequity as the reviewed courses were centered around the European region. There were also differences in the mode of delivery, as there was a preference for online delivery of courses, and many of them were diploma or certificate courses. Acknowledging the essence of these frameworks in tackling real‐world issues, OH/PH/EH education should be made more available in higher education to help mould OH/PH/EH‐oriented professionals.
Validation of the Aeolus L2B Rayleigh winds and ECMWF short‐range forecasts in the upper troposphere and lower stratosphere using Loon super pressure balloon observations
Authors: Bley Sebastian , Rennie Michael , Žagar Nedjeljka , Pinol Sole Montserrat , Straume Anne Grete , Antifaev James , Candido Salvatore , Carver Robert , Fehr Thorsten , von Bismarck Jonas , Hünerbein Anja , Deneke Hartwig 
Published: October 2022

AbstractThe novel Aeolus satellite, which carries the first Doppler wind lidar providing profiles of horizontal line‐of‐sight (HLOS) winds, addresses a significant gap in direct wind observations in the global observing system. The gap is particularly critical in the tropical upper troposphere and lower stratosphere (UTLS). This article validates the Aeolus Rayleigh–clear wind product and short‐range forecasts of the European Centre for Medium‐Range Weather Forecasts (ECMWF) with highly accurate winds from the Loon super pressure balloon network at altitudes between 16 and 20 km. Data from 229 individual balloon flights are analysed, applying a collocation criterion of 2 hr and 200 km. The comparison of Aeolus and Loon data shows systematic and random errors of 0.31 and 6.37 ms, respectively, for the Aeolus Rayleigh–clear winds. The horizontal representativeness error of Aeolus HLOS winds (nearly the zonal wind component) in the UTLS ranges from 0.6–1.1 ms depending on the altitude. The comparison of Aeolus and Loon datasets against ECMWF model forecasts suggests that the model systematically underestimates the HLOS winds in the tropical UTLS by about 1 ms. While Aeolus winds are currently considered as point winds by the ECMWF data assimilation system, the results of the present study demonstrate the need for a more realistic HLOS wind observation operator for assimilating Aeolus winds.
Machine learning approach for the prediction of surface tension of binary mixtures containing ionic liquids using σ‐profile descriptors
Authors: Benmouloud Widad , Si‐Moussa Cherif , Benkortbi Othmane 
Published: October 2022

AbstractIonic liquids (IL) are a new class of liquids considered as green solvents; less toxic, less flammable, and less polluting which retain their liquid state over wide temperature ranges and are considered alternatives to volatile organic solvents. The surface tension of IL‐organic solvent mixtures plays an important role in the design and development of many industrial processes. This work investigated the capability and feasibility of four ANN model topologies (“trainbr, logsig”; “trainbr, tansig”; “trainlm, logsig”; “trainlm, tansig”), a PSO‐SVM model, and an LSSVM model to predict the surface tension of binary systems containing IL. For this purpose, 1623 data points corresponding to the experimental surface tension values of binary mixtures containing IL were collected from the literature. The surface tension values were between 18.9 and 72.7 mN m−1. The temperature, the composition in mole fraction of IL (XIL), descriptors based on the sigma profiles, relating to the H‐bond donor and to the H‐bond acceptor character, the anion, the cation and the solvent were used as input variables of the model in order to differentiate the different compounds involved in the binary systems. A comparison of the experimental and the predicted values in terms of several statistical metrics showed good agreement, however, the prediction (trainbr, logsig) was better than the other approaches with an overall average absolute relative deviation of .8466% and a mean square error of .4952. These results are very encouraging for future projects modeling other physical and chemical properties of ILs.
Survival benefit of combinatorial osimertinib rechallenge and entrectinib in an EGFR‐mutant NSCLC patient with acquired LMNA‐NTRK1 fusion following osimertinib resistance
Authors: Wang Jiao‐Li , Wang Liu‐sheng , Zhu Jun‐qi , Ren Jie , Wang Di , Luo Man 
Published: October 2022

AbstractAcquired resistance to osimertinib is inevitable and heterogeneous despite its documented efficacy against EGFR‐mutated non‐small cell lung cancer (NSCLC). Subsequent therapeutic options assume the dominant form of the resistance mechanism; however, the more rare oncogenic driver, NTRK1 fusion, has also reportedly conferred osimertinib resistance. Nevertheless, clear‐cut options when NSCLCs are driven by EGFR mutation and the subsequent NTRK fusion are lacking. This is a case of NSCLC wherein exon 19 deletion in EGFR (19del) and acquired LMNA‐NTRK1 fusion were accompanied by the persistence of EGFR T790M. The patient underwent peritoneal metastasis after multiple targeted therapies: gefitinib, osimertinib, chemotherapy, and anlotinib plus docetaxel (in clinical trials). Osimertinib was subsequently re‐administered with the NTRK fusion inhibitor entrectinib, resulting in remission of peritoneal metastases even after slow progression of pancreatic metastasis over the following 5 months. An extensive literature review to identify the efficacies of therapies for NTRK fusion as the means to acquired resistance to EGFR TKIs revealed that blocking both the EGFR mutation and the subsequent NTRK fusion can provide clinical benefits following EGFR TKIs resistance; however, the efficacy and safety of combination therapies must be further investigated. To precisely manage EGFR‐mutated NSCLCs, it is also essential to identify the resistance mechanisms by repeating biopsies.