bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between lifestyle-related risk factors and survival in patients with colorectal cancer in an urban South African cohort
Authors: Whelan Megan , Van Aswegen Heleen , Roos Ronel , Fabian June , Bebington Brendan , Neph Cert 
Published: May 2022

Background: Lifestyle-related factors have been linked with risk for colorectal cancer. Data describing the relationship between lifestyle factors of South African patients who present with colorectal cancer and their survival is sparse.Objectives: The objectives were to describe the profile of patients with colorectal cancer; to determine the association between lifestyle-related factors and survival, and to compare results of patients in the private and public sectors.
Methods: A retrospective review and secondary analysis of information of patients with colorectal cancer were conducted. The independent samples t-test and Mann Whitney U test were administered to determine differences in the clinical presentation. Pearson’s Chi-Squared and Eta (η) tests were used to determine the association between survival and lifestyle-related factors.Results: Data of 441 patients were included. When compared to the public sector cohort, patients in the private sector cohort were older (p=0.0110), had earlier stages of cancer at the time of diagnosis (p<0.001), had a higher percentage of current alcohol consumption (p<0.001) and had higher survival rates (p<0.001). Waist circumference was shown to have a large-strength effect on survival (η2=0.266).Conclusion: Emphasis should be placed on anthropometric screening and education to effect long-term behaviour change. Physiotherapists are well placed to provide screening and non-pharmacological interventions for patients with colorectal cancer.
Keywords: Cancer survival; risk factors; physiotherapy.
Effects of hypohydration and fluid balance in athletes’ cognitive performance: a systematic review
Authors: Dube Adiele , Gouws Chantell , Breukelman Gerrit 
Published: May 2022

Background: The effects of progressive body fluid loss on athletic and cognitive performance are known to result from exposure to environmental heat stress, morphologic factors, and limited fluid replenishment. Athletes need to restore lost body water. However, athletes may fail to maintain euhydration during exercise. This systematic review investigated hypohydration and fluid balance effects on an athlete’s cognitive function.
Methods: The PubMed, Sports Discuss, and Ebsco databases were searched for studies reporting on hypohydration, fluid balance and heat on cognitive performance in sport. Multiple phrases including hydration, dehydration, fluid balance, mood, cognition, vigilance, decision making, and brain were explored. Participants in the studies did either receive fluid or did not receive fluid during exercise.
Results: Twenty-four trials (n=493 participants) from 24 articles met the inclusion criteria. Significant hypohydration, >2% body mass loss was reported consistently in 16 publications. Five articles where hypohydration was associated with heat stress and limited fluid intake (3-5% body mass loss) impaired cognitive performance. Mood disturbance, fatigue, and ratings of perceived exertion constantly complemented hypohydration impairment on cognition.
Conclusion: Findings show that hypohydration impairs cognitive performance and mood at higher levels of 3-5% body mass loss. However, sport-specific cognitive protocols of accessing hypohydration and fluid balance in individual and team sports remain equivocal.
Keywords: Hypohydration; cognition; mood; fluid replenishment.
In vitro antioxidant and cytotoxicity activities of selected indigenous South African medicinal plants
Authors: Vakele Yonela , Odun-Ayo Frederick , Reddy Lalini 
Published: May 2022

Background: Medicinal plants are regarded as a large source of phytochemicals that may have anticancer properties. This could lead to the development of innovative drugs or alternative therapy against cancer.
Objective: This study was designed to determine the antioxidant and cytotoxicity effect of 5 selected indigenous South African medicinal plants namely; Bulbine frutescens, Bulbine natalensis, Chlorophytum comosum, Kniphofia uvaria, and Tulbaghia violacea.
Method: Phytochemical extracts namely; methanol, 50%, 100% ethanol, and water extracts were prepared from the root and shoot of the plants. The antioxidant effect of methanol extracts of the plant materials was performed using a DPPH assay. A preliminary cytotoxicity screening of the phytochemical extracts in the human colon (Caco-2), cervical (HeLa), and hepatocellular (HepG2) cell lines were determined followed by the half-maximal inhibitory concentration (IC50) using MTT assay.
Result: The methanol root extract of B. natalensis and B. frutescens (33.20% and 26.33% respectively) and shoot extract of K. uvaria (17.10%) showed the highest antioxidant. Out of the 5 plants, only 100% ethanol extract of C. comosum, K. uvaria, and T. violacea caused more than 80% cytotoxicity in HepG2 and Caco-2 cell lines. The shoot of B. frutescens (10.43 μg/ml), K. uvaria (23.0 μg/ml), and root of C. comosum (23.77 μg/ml) were the most active with the highest cytotoxicity.
Conclusion: C. comosum, K. uvaria, and T. violacea possess significant cytotoxicity that is promising in developing alternative drugs against colon and liver cancers. Our results provided new pieces of evidence for antioxidant and cytotoxic activities of these plants which could be useful for developing new anticancer therapies.
Keywords: In vitro antioxidant; cytotoxicity activities; South African medicinal plants; C. comosum, K. uvaria, T. violacea.
Co-occurrence of antibiotic resistance and virulence Genes in Methicillin Resistant Staphylococcus aureus (MRSA) Isolates from Pakistan
Authors: Tasneem Ufaq , Majid Mahnoor , Mehmood Khalid , Redaina  , Ur Rehman Fazal , Andleeb Saadia , Jamal Muhsin 
Published: May 2022

Introduction: Methicillin resistant Staphylococcus aureus (MRSA) is one of the major human pathogen that is associated with hospital as well as community acquired infections and is responsible for huge amount of life-threatening diseases.
Objective: Objective of the study was to determine MRSA prevalence, their antibiotic sensitivity patterns, frequency of virulence genes (sea, seb, sed, tst, hla, hld) and their co-occurrence with resistance marker mecA among Rawalpindi and its nearby regions of Pakistani clinical isolates.
Methodology: The present study was carried out to identify the virulence and antibiotic resistance genes that co-occur in MRSA through polymerase chain reaction. Antibiotic sensitivity, presence of virulence genes and their co-occurrence with resistance marker mecA were analyzed.
Results: These isolates were found resistant to number of antibiotics i.e. Amoxicillin (16.1%), Cefixime (48.38%), Doxycycline (27.415), Trimethoprim/sulfamethoxazole (37.09%), Clindamycin (30.64%), Erythromycin (83.87%), Penicillin (100%), Vancomycin (4.83%), Ciprofloxacin (70.96%), Tetracycline (20%), Linezolid (3.22%) and Fusidic acid (11.295). The frequency of antibiotic resistant gene (mecA) was 69.35% and that of virulence genes hla, hld, sea, seb, sed and tst was 100, 100, 53.2, 30.6, 3.2 and 24.2% respectively. Amongst all examined genes, hla and hld genes had the highest and sed gene had the lowest frequency. The maximum coexistence of genes was observed for hla+hld+mecA gene combination (42 out of 62 isolates).
Conclusion: This study reports the presence of multidrug resistant, vancomycin-resistant and mecA negative MRSA isolates in infected patients of Rawalpindi and nearby regions of Pakistan that may have attributed to treatment failures, adaptability of new virulence characteristics and spread of antibiotic resistance.
Keywords: Methicillin resistant Staphylococcus aureus; Antibiotic resistance; Virulence; mecA; Pakistan.
Circulation of hepatitis B virus genotype-E among outpatients in tertiary hospitals in the Niger-Delta region of Nigeria
Authors: F Umego Chinenye , I Mboto Clement , D Asitok Atim , C Osaji Linda , E George Uwem , Uwem O Edet  , N Mbim Elizabeth , OC Faleye Temitope , M Adewumi Olubusuyi , A Adeniji Johnson 
Published: May 2022

Introduction: Hepatitis B virus (HBV) infection continues to be a significant public health challenge globally, with higher disease burden in developing countries. HBV genotypes are associated with different geographical regions and clinical outcomes. Limited information exists on epidemiology of HBV in the Niger-Delta region (South-South) of Nigeria. Consequently, this study was designed to characterise hepatitis B virus infection among outpatients in selected tertiary hospitals in the region.
Methodology: Between June and August 2017, consenting nine hundred asymptomatic out-patients were enrolled and initially screened for HBV infection using one step Hepatitis B surface antigen (HBsAg) strip and subsequently re-tested using HBsAg and Hepatitis B core total antibody (anti-HBc) specific Enzyme-Linked Immunosorbent Assay (ELISA). Blood serum with detectable HBsAg were subsequently subjected to DNA extraction, S-gene amplification using a nested polymerase chain reaction (PCR) protocol, gel electrophoresis, sequencing and phylogenetic analysis.
Results: Seroprevalence of HBsAg was 4.6% (95% CI 2.5-7.1) and anti-HBc was 10.1% (95% confidence interval (CI) 6.1-15.3). Of the 41 HBsAg positive samples subjected to DNA extraction and HBV S-gene specific PCR, only 6 (14.6%) yielded the expected~408bp band. Phylogenetic analysis based on HBV pre-S/S sequences identified all six typable samples as genotype E, subtype ayw4 of the West African clade.
Conclusion: Results of the study confirm the presence and circulation of HBV genotype-E in the Niger-Delta region of Nigeria, thus corroborating the inclusion of the country in the Genotype E crescent. The authors advocate value-added HBV intervention in the region and the country at large.
Keywords: HBsAg; HBV; Niger-Delta; Nigeria; South-South.
The predictive role of psychological toughness and adaptability on the actual well-being of mothers with handicapped children
Authors: Hamid Salehian Mir 
Published: May 2022

Background and Aim: Handicapped children cause psychological problems for mothers. As mothers' actual well-being is so important in the family and society, the aim of this research was to predict the role of psychological toughness and adaptability on the actual well-being of mothers with handicapped children.
Materials and Methods: The research was descriptive correlational study with volunteer mothers of handicapped children (n=150). Data collection tools were: Ahwaz Kiamarsi et al. (1998) psychological toughness questionnaire, Connor and Davidson adaptability scale (2003), Lyubomerisky and Leper actual well-being scale (1999) and Diener life satisfaction scale (2009). Pearson correlation coefficient and multiple linear regression analysis were used to analyze the data using SPSS 21 version.
Results: The results showed that psychological toughness and its components (commitment, control, struggle) have a significant positive relationship with the actual well-being of mothers with handicapped children and its dimensions (actual well-being and life satisfaction) and is able to predict their well-being.
Discussion: Therefore, it can be said that by promoting adaptability, mothers with handicapped children can resist and overcome stressors as well as factors that cause many psychological problems. By reducing psycho-emotional problems in mothers, mental well-being and life satisfaction are improved.
Conclusion: The actual well-being of mothers with handicapped children can be predicted by their psychological toughness and adaptability.
Keywords: Psychological toughness; adaptability; actual well-being; handicapped children.
Evaluation of Pasting Properties of Plantain, Cooking Banana, Selected Cereals and their Composites as Indicators for their Food Values
Authors: Agbaje Wasiu B. , Abiona Oluseye O. , Awojide Shola H. , Azeez Luqman A. , Tayo Adeniyi S. 
Published: May 2022

The pasting properties of unripe plantain, unripe cooking banana, some selected cereals and their composite flours were investigated in relation to their food values. Each of the samples was cleaned, air–dried and pulverized to form the native flours which were mixed in different proportions to form the composite flours. Soft doughs were prepared from the flours and subjected to textural evaluation. The adjudged best from each set was analysed using Rapid Visco–Analyser followed by determination of their proximate composition and functional properties. The results showed that the breakdown viscosity (cP) of each of the composite flours was less than 920.50 in plantain and 915.50 in cooking banana, indicating improved ability to withstand shear stress. The values of the final viscosity of the composite flours were generally lower than the native flours of plantain and cooking banana which indicated better flow property. The setback viscosities of the composite flours were lower than the native cereal flours except sorghum which indicated lower tendency to undergo retro–degradation. Furthermore, the composite flours gelled at lower temperature (72.1–84.9 °C) when compared with the native flours (82.7–89.2 °C) reflecting less energy requirement for cooking. Combination of cereals with plantain or cooking banana had led to production of composite flours which gave better and improved pasting properties without depreciation in functional properties and nutritional composition.
Keywords: Composite flour; Cereal–plantain; Cereal–cooking banana; Proximate composition; Functional and pasting properties.
Design and Implementation of Distributed Identity and Access Management Framework for Internet of Things (IoT) Enabled Distribution Automation
Authors: Bitebo Ally T , Maziku Hellen , Hamisi Ndyetabura , , Tarimo Charles N , Ibwe Kwame S , Abdalla Abdi T. 
Published: May 2022

The smart grid and Internet of Things (IoT) technologies play vital roles in improving the quality of services offered in traditional electrical grid. They open a room for the introduction of new services like distribution automation (DA) that has a significant advantage to both utility companies and final consumers. DA integrates sensors, actuators, intelligent electrical devices (IED) and information and communication technologies to monitor and control electrical grid. However, the integration of these technologies poses security threats to the electrical grid like Denial of Service (DoS) attacks, false data injection attacks, and masquerading attacks like system node impersonation that can transmit wrong readings, resulting in false alarm reports and hence leading to incorrect node actuation. To overcome these challenges, researchers have proposed a centralized public key infrastructure (PKI) with bridged certificate authority (CA) which is prone to DoS attacks. Moreover, the proposed blockchain based distributed identity and access management (DIAM) in IoT domain at the global scale is adding communicational and computational overheads. Also. It is imposing new security threats to the DA system by integrating it with online services like IoTEX and IoTA. For those reasons, this study proposes a DIAM security scheme to secure IoT-enabled distribution automation. The scheme divides areas into clusters and each cluster has a device registry and a registry controller. The registry controller is a command line tool to access and manage a device registry. The results show that the scheme can prevent impersonated and non-legitimate system nodes and users from accessing the system by imposing role-based access control (RBAC) at the cluster level.
Keywords: Distributed Identity and Access Management; Electrical Secondary Distribution Network; Internet of Things; IoT Enabled Distribution Automation; Smart Grid Security
Comparison of Different Foam Rolling Protocols on Ankle Range of Motion, Strength, Muscle Activation and Jump Performance
Authors: Soares Enrico , Martins Almeida Vinícius , Megumi Wakuda de Abreu Vasconcelos Christine , Henrique Barbosa de Jesus João , Ricardo Lopes Charles 
Published: May 2022

Background: Foam rolling (FR) has been widely used with the intent to increase range of motion (ROM) before strength and power activities. At the moment, few studies have investigated practical strategies to control FR intensity. Purpose: The aim was to compare the effect (FR) intensity by different combinations of a smooth roller, grid roller, unilateral or bilateral rolling massage on the triceps suralis ROM, strength, muscle activation, and jump performance. Methods: Ten male (28±4 years, 175±5 cm, 81±13 kg) and ten female (29±4 years, 163±5 cm, 66±10 kg) recreationally trained performed two sessions of data collection that compared 4 combinations of rolling surface and technique: unilateral smooth roller (US), bilateral smooth roller (BS), unilateral grid roller (UG), and bilateral grid roller (BG). During all conditions, the triceps suralis was rolled for 2 sets of 60 s with 60 s of rest between sets. Rate of perceived pain (RPP) after the rolling protocol; peak force during a maximal voluntary isometric contraction (MVIC) (PF), muscle activation during a MVIC, and unilateral drop jump (UDJ) performance were measured before and after each condition. Results: The greatest RPP was reported in UG condition and the lowest RPP was reported in BS condition. All conditions increased ankle ROM to the same extent without subsequent effect on PF, muscle activity UDJ height, and UDJ contact time. Our data indicate that FR using different combinations of surface pattern and rolling techniques increased ankle ROM without a subsequent effect on drop jump performance, triceps suralis strength, and activation. Conclusion: In conclusion, practitioners could be encouraged to perform FR with mild discomfort and use a bilateral technique to save time.
Keywords: Flexibility, self-myofascial release, electromyography, force, strength.
The Use of Audio-Visual Materials in Teaching and Learning Process in Effia Junior High Schools
Authors: Kwegyiriba Adwoa , Mensah Ronald Osei , Ewusi Elizabeth 
Published: May 2022

This study aims to find out the use of audio-visual materials at the Junior High School level. Despite the fact that the use of audio-visual materials is a proper current technological tool to motivate students, it prevails a set of challenges in the availability of audio-visual materials in Effia public Junior High Schools. The study seeks to provide information on the existing situation about the availability and use of Audio-visual materials in teaching students in Junior High Schools in Effia, in Effia Kwesimintsim Municipal Assembly. This study used qualitative approach, and censused all the nine public Junior High schools in Effia with ten students and one teacher randomly selected from each public JHS in Effia to form a sample size of 99 respondents for the study. Despite the significant role played by the use of audio-visual materials in the Ghanaian educational system. The findings revealed that although the students in the nine public JHS in Effia are not taught using Audio-Visual materials by their teachers, they still have the desire to be taught using those materials and this was affirmed with a significant majority of the students saying they desired to be taught with Audio-Visual materials in their various classrooms experience. The research recommended that Audio-Visual materials should be made available by Stakeholders in the educational sector such as; the Parent Teacher Association (P.T.A), the municipal assembly, the ministry of education, the Ghana Education Service, individual philanthropists, and non-governmental organizations.
Алоуддин Аттор ижтимоий-маънавий фаолиятида “Нафс” ва “Ҳуш ҳар дам” талқини
Authors: Раҳматов Эркин 
Published: May 2022

Ушбу мақолада машҳур мутасаввиф шайх Алоуддин Атторнинг ижтимоий-маънавий фаолиятида нафс ва “ҳуш ҳар дам” талқини, шунингдек, нафсни тарбиялашнинг энг мукаммал йўл “даст ба кор”лик(ҳалол меҳнат қилиш)нинг “дил ба ёр”лик билан уйғун бўлишининг ижтимоий моҳияти ҳақида сўз юритилади.
Pengaruh Lokasi Dan Harga Terhadap Keputusan Pembelian Perumahan Puri Hijau Di Kabupaten Cirebon
Authors: Ayu Aprilia Nabila Christina , Dhea Praadha Gitama Gytha Nurhana 
Published: May 2022

This study aims to determine whether there is an influence of location on purchasing decisions for Puri Hijau Housing in Cirebon district, the effect of price on purchasing decisions for Puri Hijau Housing in Cirebon district, the influence of location and price simultaneously on purchasing decisions for housing Puri Hijau Cirebon housing. The population studied in this study were 125 consumers of Puri Hijau Housing. The sampling technique used the slovin formula with a total sample of 56 consumers. The data collection technique uses a Google Form questionnaire that has been tested for validity and reliability tests. The data analysis technique used is multiple linear regression analysis. The results showed that: there is an influence of location on the decision of Puri Hijau Housing in Cirebon district, there is an influence of price on the purchasing decision of Puri Hijau Housing in Cirebon district, there is a simultaneous influence of location and price on the purchasing decision of Puri Hijau Housing in Cirebon district Key words: Location, Price and Purchase Decision
Pengaruh Implementasi Quality Management System (Qms) Dan Layout Mesin Terhadap Kualitas Produksi Kemasan Botol Minum Dengan Penerapan Good Manufacturing Practice (Gmp) Sebagai Variabel Moderasi Pada PT. Diamond
Authors: Kellyen Andrew , Yani Ari Soeti 
Published: May 2022

This study aims to determine the effect of the implementation of a quality management system (QMS) and machine layout on the quality of drinking bottle packaging production with the application of good manufacturing practice (GMP) as a moderating variable at PT. Diamonds. The results showed that the implementation of the Quality Management System (QMS) had a significant and positive effect on the quality of plastic bottle packaging production. Machine Layout has a significant and positive effect on the production of plastic bottle packaging. The Good Manufacturing Practices (GMP) system has a significant and positive effect on the production of plastic bottle packaging. The Good Manufacturing Practices (GMP) system has an insignificant and positive effect and is unable to moderate the implementation of the Quality Management System (QMS) on the production of plastic bottle packaging. System Good Manufacturing Practices (GMP) has a negative insignificant effect, unable to moderate Machine Layout on the production of plastic bottle packaging Keywords: Quality Management System (QMS), Machine Layout, Production Quality, Good Manufacturing Practice (GMP)
Intelligent Technologies and Lost Life
Authors: Rapoport Michele 
Published: May 2022

Intelligent systems and devices are at the forefront of technological innovation and hold particular appeal for the creative imagination. Their appearance in the arts, fiction, and film allow one to glean insights into apprehensions regarding the contemporary human condition and concerns for its future. This study examines the loss of life and the absencing of the other as embodied in intelligent devices, as they are presented in three current, popular films. In these films, human fallibility and mortality provide the raison d’être for the creation and development of intelligent devices and systems. Moreover, the power that these technologies hold is in their evocation of lost life and human transience, and in the manner by which they both conceal and reveal absence and loss.