bluuebunny/crossref_metadata_2025_split huggingface dataset:
Text Topics and Treatment Response in Internet-Delivered Cognitive Behavioral Therapy for Generalized Anxiety Disorder: Text Mining Study
Authors: Mylläri Sanna , Saarni Suoma Eeva , Ritola Ville , Joffe Grigori , Stenberg Jan-Henry , Solbakken Ole André , Czajkowski Nikolai Olavi , Rosenström Tom 
Published: November 2022

Background
Text mining methods such as topic modeling can offer valuable information on how and to whom internet-delivered cognitive behavioral therapies (iCBT) work. Although iCBT treatments provide convenient data for topic modeling, it has rarely been used in this context.

Objective
Our aims were to apply topic modeling to written assignment texts from iCBT for generalized anxiety disorder and explore the resulting topics’ associations with treatment response. As predetermining the number of topics presents a considerable challenge in topic modeling, we also aimed to explore a novel method for topic number selection.

Methods
We defined 2 latent Dirichlet allocation (LDA) topic models using a novel data-driven and a more commonly used interpretability-based topic number selection approaches. We used multilevel models to associate the topics with continuous-valued treatment response, defined as the rate of per-session change in GAD-7 sum scores throughout the treatment.

Results
Our analyses included 1686 patients. We observed 2 topics that were associated with better than average treatment response: “well-being of family, pets, and loved ones” from the data-driven LDA model (B=–0.10 SD/session/∆topic; 95% CI –016 to –0.03) and “children, family issues” from the interpretability-based model (B=–0.18 SD/session/∆topic; 95% CI –0.31 to –0.05). Two topics were associated with worse treatment response: “monitoring of thoughts and worries” from the data-driven model (B=0.06 SD/session/∆topic; 95% CI 0.01 to 0.11) and “internet therapy” from the interpretability-based model (B=0.27 SD/session/∆topic; 95% CI 0.07 to 0.46).

Conclusions
The 2 LDA models were different in terms of their interpretability and broadness of topics but both contained topics that were associated with treatment response in an interpretable manner. Our work demonstrates that topic modeling is well suited for iCBT research and has potential to expose clinically relevant information in vast text data.
Digital Health Technology to Support Health Care Professionals and Family Caregivers Caring for Patients With Cognitive Impairment: Scoping Review
Authors: Choukou Mohamed-Amine , Olatoye Funminiyi , Urbanowski Reg , Caon Maurizio , Monnin Caroline 
Published: November 2022

Background
Digital health technology is a promising way of supporting health care providers and family caregivers as they care for patients with cognitive impairment.

Objective
This scoping review aimed to portray the use of digital health technology to assist health care providers and family caregivers in caring for patients with cognitive impairment who live in the community or in a facility.

Methods
We conducted a scoping review of peer-reviewed scientific articles available in MEDLINE, PsycINFO, Scopus, and CINAHL with Full Text, as well as gray literature available in preprint servers, theses depositories, and various national and international dementia organizations’ websites. The search yielded 975 articles, of which we included 7 (0.7%) in the review.

Results
Of the 7 interventions included in the retrieved manuscripts, 2 (29%) were digital calendar reminder systems to support activities of daily living and medication management; 2 (29%) were apps on tablet devices to simulate the presence of family before therapy interventions; 1 (14%) was a social robot used in therapeutic sessions to include elements of musicotherapy, reminiscence, cognitive games, and relaxation; 1 (14%) was a commercially available computer system that provides access to various recreational leisure activities; and 1 (14%) was a web-based self-management support system that helps family caregivers to deal with behavior changes in a relative with dementia. Of the 7 articles, only 1 (14%) reported on the use of a behavior change theory, namely a comprehensive process model of engagement coupled with cognitive stimulation therapy.

Conclusions
Literature on the topic is scarce, recent, and heterogeneous. There is a clear need for a theoretical framework to conceptualize and govern the use of behavior change models that incorporate technology for patients with cognitive impairment.
Ice Flavor–Related Discussions on Twitter: Content Analysis
Authors: Galimov Artur , Vassey Julia , Galstyan Ellen , Unger Jennifer B , Kirkpatrick Matthew G , Allem Jon-Patrick 
Published: November 2022

Background
The US Food and Drug Administration (FDA) recently restricted characterizing flavors in tobacco products. As a result, ice hybrid–flavored e-cigarettes, which combine a cooling flavor with fruit or other flavors (eg, banana ice), emerged on the market. Like menthol, ice-flavored e-cigarettes produce a cooling sensory experience. It is unclear if ice hybrid–flavored e-cigarettes should be considered characterizing flavors or menthol, limiting regulatory action. Monitoring the public’s conversations about ice-flavored e-cigarettes on Twitter may help inform the tobacco control community about these products and contribute to the US FDA policy targets in the future.

Objective
This study documented the themes pertaining to vaping and ice flavor–related conversations on Twitter. Our goal was to identify key conversation trends and ascertain users’ recent experiences with ice-flavored e-cigarette products.

Methods
Posts containing vaping-related (eg, “vape,” “ecig,” “e-juice,” or “e-cigarette”) and ice-related (ie, “Ice,” “Cool,” “Frost,” and “Arctic”) terms were collected from Twitter’s streaming application programming interface from January 1 to July 21, 2021. After removing retweets, a random sample of posts (N=2001) was selected, with 590 posts included in the content analysis. Themes were developed through an inductive approach. Theme co-occurrence was also examined.

Results
Many of the 590 posts were marked as (or consisted of) marketing material (n=306, 51.9%), contained positive personal testimonials (n=180, 30.5%), and mentioned disposable pods (n=117, 19.8%). Other themes had relatively low prevalence in the sample: neutral personal testimonials (n=45, 7.6%), cannabidiol products (n=41, 7%), negative personal testimonials (n=41, 7%), “official” flavor description (n=37, 6.3%), ice-flavored JUUL (n=19, 3.2%), information seeking (n=14, 2.4%), and comparison to combustible tobacco (n=10, 1.7%). The most common co-occurring themes in a single tweet were related to marketing and disposable pods (n=73, 12.4%).

Conclusions
Our findings offer insight into the public’s experience with and understanding of ice-flavored e-cigarette products. Ice-flavored e-cigarette products are actively marketed on Twitter, and the messages about them are positive. Public health education campaigns on the harms of flavored e-cigarettes may help to reduce positive social norms about ice-flavored products. Future studies should evaluate the relationship between exposure to personal testimonials of ice-flavored vaping products and curiosity, harm perceptions, and experimentation with these products among priority populations.
Nigerian and Ghanaian Young People’s Experiences of Care for Common Mental Disorders in Inner London: Protocol for a Multimethod Investigation
Authors: Isiwele Anthony , Rivas Carol , Stokes Gillian 
Published: November 2022

Background
The Care Quality Commission published a review in 2018 in England titled “Are We Listening,” which revealed that child and adolescent mental health services are not responsive to the specific needs of young Black people and other ethnic minorities even in areas with ethnically diverse populations. It found that commissioners and service planners failed to engage with these young people and their families to understand their needs and expectations.

Objective
The purpose of this study is to engage Nigerian and Ghanaian young people (NAGYP) with experiences of care for common mental disorders (CMDs) in London, to increase understanding of their needs, and to give voice to their views and preferences. Their parents’, caregivers’, and practitioners’ views will also be sought for service improvement.

Methods
Three combined contemporary complementary methodologies—thematic analysis, interpretative phenomenological analysis (IPA), and intersectionality-based policy analysis (IBPA)—will be used across 3 comprehensive phases. First, a scoping review where relevant themes will be critically analyzed will inform further phases of this study. Detailed mapping of community and mental health care services in 13 inner London boroughs to investigate what professionals actually do rather than what they say they do. Second, IBPA will be used to scrutinize improving access to psychological therapies and other legislations and policies relevant to NAGYP to undertake an intersectional multileveled analysis of power, models, and constraints. Third, IPA will “give voice” and “make sense” of NAGYP lived experiences of CMDs via a representative sample of NAGYP participants’ (n=30) aged 16-25 years, parents or caregivers’ (n=20), and practitioners’ (n=20) perspectives will be captured.

Results
The study has been approved by the UCL Institute of Education Research Ethics Committee (Z6364106/2022/02/28; health research) and University College London (Z6364106/2022/10/24; social research). Recruitment has begun in 13 inner boroughs of London. Data collection through observation, semistructured interviews, and focus groups are expected to be finalized by early 2024, and the study will be published by early 2025.

Conclusions
Combining multiple qualitative methodologies and methods will enable rigorous investigation into NAGYP’s lived experiences of care received for CMDs in London. Findings from this study should enable a reduction in the negative connotations and harmful superstitions associated with mental health–related issues in this group, inform evidence-based interventions, and facilitate preventive or early access to interventions. There may also be an indirect impact on problems resulting from mental illness such as school dropout, antisocial behaviors, knife crimes, juvenile detention centers, and even death.

International Registered Report Identifier (IRRID)
PRR1-10.2196/42575
Design Validation of a Relational Agent by COVID-19 Patients: Mixed Methods Study
Authors: Islam Ashraful , Chaudhry Beenish Moalla 
Published: November 2022

BackgroundRelational agents (RAs) have shown effectiveness in various health interventions with and without doctors and hospital facilities. In situations such as a pandemic like the COVID-19 pandemic when health care professionals (HCPs) and facilities are unable to cope with increased demands, RAs may play a major role in ameliorating the situation. However, they have not been well explored in this domain.ObjectiveThis study aimed to design a prototypical RA in collaboration with COVID-19 patients and HCPs and test it with the potential users, for its ability to deliver services during a pandemic.MethodsThe RA was designed and developed in collaboration with people with COVID-19 (n=21) and 2 groups of HCPs (n=19 and n=16, respectively) to aid COVID-19 patients at various stages by performing 4 main tasks: testing guidance, support during self-isolation, handling emergency situations, and promoting postrecovery mental well-being. A design validation survey was conducted with 98 individuals to evaluate the usability of the prototype using the System Usability Scale (SUS), and the participants provided feedback on the design. In addition, the RA’s usefulness and acceptability were rated by the participants using Likert scales.ResultsIn the design validation survey, the prototypical RA received an average SUS score of 58.82. Moreover, 90% (88/98) of participants perceived it to be helpful, and 69% (68/98) of participants accepted it as a viable alternative to HCPs. The prototypical RA received favorable feedback from the participants, and they were inclined to accept it as an alternative to HCPs in non-life-threatening scenarios despite the usability rating falling below the acceptable threshold.ConclusionsBased on participants’ feedback, we recommend further development of the RA with improved automation and emotional support, ability to provide information, tracking, and specific recommendations.
Phase IIIb study of the bevacizumab biosimilar candidate BI 695502 plus mFOLFOX6 in metastatic colorectal cancer
Authors: Bekaii-Saab Tanios S , Balser Sigrid , Lohmann Ragna , Daoud Hasan , Liedert Bernd , Schliephake Dorothee 
Published: November 2022

Aim: This study assessed the safety, efficacy, pharmacokinetics and immunogenicity of the bevacizumab biosimilar candidate BI 695502 plus mFOLFOX6 in patients with metastatic colorectal cancer (mCRC). Materials & methods: Patients with untreated mCRC received BI 695502 and chemotherapy (oxaliplatin, leucovorin and 5-fluorouracil). Primary end point: proportion of patients with prespecified adverse events (AEs). Results: Of 123 patients enrolled and treated, 58.5% experienced prespecified AEs. Median progression-free survival was 10.5 months, median overall survival was 19.4 months, and objective response rate was 61.0%. There were no antidrug antibody or neutralizing antidrug antibody-positive samples post-baseline. Trough BI 695502 plasma concentrations increased until cycle 9 and stabilized thereafter. Conclusion: BI 695502 has an acceptable safety and efficacy profile in the treatment of mCRC. Trial Registration Number: NCT02776683 ( ClinicalTrials.gov ), 2015-003718-25 (EudraCT, European Clinical Trials Database https://www.clinicaltrialsregister.eu/ctr-search/search?query=2015-003718-25 ) Study name: Study 1302.3
Encuentros y tensiones en la atención de salud sexual y reproductiva de población joven mapuche: una aproximación cualitativa
Authors: Obach Alexandra , Carreño Alejandra 
Published: November 2022

Introducción: Desde las determinantes sociales de la salud los jóvenes indígenas presentan menos años de escolaridad, viven en condiciones socioeconómicas más desventajadas y tienen menos acceso a salud en general respecto a sus pares no indígenas.
Objetivo: El estudio pretende explorar en las construcciones de significado de jóvenes mapuche de entre 18 y 24 años en torno a sus cuerpos y sexualidades, e indagar en las tensiones y/o puntos de encuentro que se producen al confrontar la visión de los/las jóvenes con las construcciones que sobre este ámbito imperan en el sistema de salud, en la región de La Araucanía.
Metodología: Estudio cualitativo, realizado entre jóvenes mapuches y equipos de salud de atención primaria durante los años 2020-2021. Se aplicaron entrevistas semiestructuradas y en profundidad a una muestra de 29 personas.
Resultados: Se encontraron dificultades de los equipos para abordar la atención de salud sexual y reproductiva desde una óptica intercultural. Se registra poco conocimiento de las necesidades de la población joven indígena, perpetuándose un enfoque centrado en el control de la fecundidad y gestación. Se registran transformaciones en el mundo juvenil indígena que demanda información y acceso a educación sexual, integrando diversidades sexuales y feminismos. También emergen procesos de reapropiación de valores tradicionales que incluyen itinerarios terapéuticos mixtos, con uso de medicinas indígenas y estrategias de autocuidado.
Conclusión: Es necesario generar mayor evidencia y participación de los jóvenes indígenas para la planificación de políticas públicas miradas a integrar la interculturalidad en la atención de su salud sexual y reproductiva.
THE CORRELATIONS BETWEEN EMOTIONAL INTELLIGENCE AND SPIRITUAL INTELLIGENCE TO AGGRESSIVE BEHAVIOR IN HIGH SCHOOL STUDENTS OF SMAN 6 BANDA ACEH
Authors: Lisdayani Lisdayani , Lubis Lahmuddin , Azis Azhar 
Published: November 2022

This research aims to determine the relationship of emotional intelligence and spiritual intelligence with aggressive behavior in SMA Negeri 6 Banda Aceh. The subjects in this research were student of SMA 6 Banda Aceh as many as 40 people. The sampling technique in this research is using purposive sampling technique. The measuring instruments that used in this study are the scale of emotional intelligence, the scale of spiritual intelligence and the scale of aggressive behavior. Based on the results of the analysis using the statistical method of multiple linear regression analysis showed that from the two independent variables of emotional intelligence and spiritual intelligence with the dependent variable is the aggressive behavior has a significant negative relationship, as shown by (R = -0.645; = 0.416; F = 13.183; p = 0.000). These two independent variables have effective contribution of 41.6% against the aggressive behavior. The other results in this research note that the variables of the emotional intelligence has been associated with aggressive behavior with effective contribution of 15.5% while the spiritual intelligence variables has been associated with aggressive behavior with the effective contribution of 40.9%.
Implications of Enhanced Cybersecurity Risk Management Reporting and Independent Assurance
Authors: Frank Michele L. , Grenier Jonathan H. , Pyzoha Jonathan S. , Zielinski Natalie B. 
Published: November 2022

SUMMARY
According to the World Economic Forum (WEF) (2022), cybersecurity risk is the most immediate and financially material sustainability risk that organizations face. Companies experience significant financial and reputational losses in the market after a cyberattack. However, companies are only required to disclose a trivial amount of information about their cybersecurity risk management efforts (SEC 2014; Newman 2018). This paper summarizes Frank, Grenier, and Pyzoha (2019), which examines whether voluntarily providing additional disclosures regarding a company’s cybersecurity efforts, with or without assurance, increases investment attractiveness. Absent assurance, voluntary disclosures about the nature and effectiveness of cybersecurity efforts are sufficient to increase investment attractiveness for companies that have not (versus have) disclosed a prior cyberattack, as investors are less likely to question the disclosure’s reliability. Assurance provides a greater benefit to companies that have (versus have not) disclosed a prior cyberattack, as they benefit more from the reliability enhancement of assurance.
The Influence of Corporate Social Responsibility Disclosures and Assurance on Jurors’ Judgments
Authors: Stuart Andrew C. 
Published: November 2022

SUMMARYThis study examines whether management’s corporate social responsibility (CSR) motives and CSR assurance influence jurors’ negligence and punitive damages assessments using a 2 × 2 experiment. CSR activities can provide insurance-like protection from negative reactions during a corporate crisis if stakeholders perceive altruistic motives. However, it is not known whether this insurance-like protection applies during litigation. Findings suggest that disclosure of altruistic CSR activities (i.e., without expectation of financial returns) improves jurors’ affective response to the defendant and perceptions of company behavior prior to a negative event compared to self-serving CSR activities (i.e., expectation of financial returns), which reduce negligence and punitive damages assessments. However, when disclosures are assured, the relationship changes. In this scenario, altruistic and self-serving CSR have similar influences on jurors’ judgments. Overall, results suggest that CSR disclosure and assurance may provide benefits during litigation by increasing jurors’ affective reaction to the defendant and perceptions of the company’s behavior.
Insider Horizon and Disclosure Policies
Authors: Cadman Brian , Heinle Mirko S. , Macciocchi Daniele 
Published: November 2022

ABSTRACTWe investigate the relationship between insider horizon and disclosure policy. First, we develop and analyze a rational expectations model assuming insiders are able to commit to a disclosure policy. Insiders with a short horizon prefer more disclosure and are willing to bear costs of disclosure to reduce information asymmetries among capital market participants. We then empirically test our predictions in the setting of newly public firms and firms where the CEO is approaching retirement. We find that firms with insiders that have a shorter horizon disclose more and experience lower information asymmetry. Our study contributes to the understanding of firms’ disclosure choices by suggesting that the horizon of insiders shapes a firm’s disclosure policy.JEL Classifications: G14; G32; D83.
Information, Incentives, and Attention: A Field Experiment on the Interaction of Management Controls
Authors: Manthei Kathrin , Sliwka Dirk , Vogelsang Timo 
Published: November 2022

ABSTRACT
We study the profit effects and interplay of two core accounting practices in a field experiment in a large retail chain. In a 2 × 2 factorial design, we vary (1) whether store managers obtain decision-facilitating information on a profit metric and (2) whether they receive performance pay based on the same metric. We find that both practices increase profits significantly. In contrast to reasoning based on standard economic theory, we do not find complementarity between both interventions. Rather, we detect evidence in line with an attention-directing role of both practices: the introduction of each raises attention to the underlying objective, which induces a countervailing substitution effect.
JEL Classifications: J33; M52; C93.
Tradisi Raba’akia di Bukit Air Manis Kota Padang
Authors: Meranis Cyntia , S Nurman , Isnarmi Isnarmi 
Published: November 2022

Penelitian ini bertujuan untuk menganalisis latar belakang pelaksanaan dan bentuk pergeseran pelaksanaan tradisi raba’akia, serta untuk menganalisi faktor penyebab pergeseran pelaksanaan tradisi raba’akia di bukit air manis Kota Padang. Penelitian ini menggunakan metode kualitatif deskriptif tipe etnografi. Teknik pemilihan informan dengan purposive sampling. Pengumpulan data dengan metode wawancara, dan dokumentasi. Agar data dapat dipercaya maka diuji dengan menggunakan triangulasi sumber dan teknik. Hasil penelitian ini menunjukkan bahwa latar belakang pelaksanaan tradisi raba’akia ini berasal dari mitos-mitos orang terdahulu tentang petaka yang datang sebelum diadakannya tradisi raba’akia dan sebagai bentuk wujud rasa syukur atas rahmat Allah SWT. Bentuk pergeseran pelaksanaan tradisi raba’akia ini terdiri dari tiga tahap yaitu tahap pembuka, tahap pelaksanaan serta tahap penutup. Dalam tahap pelaksanaan terdapat tiga acara yaitu acara pembuka, acara inti serta acara penutupnya. Faktor penyebab pergeseran pelaksanaan tradisi raba’akia yaitu pola pikir masyarakat, kesibukan personal, perkembangan tekhnologi dan ketergantungan masyarakat, kurangnya penduduk asli dan tokoh adat di Bukit Air Manis Kota Padang, regenerasi tradisi serta bencana alam berupa wabah Covid-19.