bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stresstest voor het formeren nieuwe stijl
Authors: van Kessel A.C.M.W. 
Published: August 2022

Stresstest voor het formeren nieuwe stijl
De kabinetsformatie die volgde op de Kamerverkiezingen van 17 maart 2021 brak alle records. Uiteindelijk trad pas na 299 dagen het kabinet-Rutte IV aan. Dat is overigens geen internationaal record. Dat staat nog steeds op naam van de Belgen, die pas 541 dagen na de parlementsverkiezingen van 13 juni 2010 een nieuwe federale ministersploeg, geleid door Elio Di Rupo, zagen aantreden. Na de verkiezingen van 26 mei 2019 volgde trouwens een nieuwe Belgische recordpoging, die ternauwernood mislukte: na 494 dagen werd het kabinet-De Croo beëdigd. De Belgen kunnen ter verdediging van hun lange formaties wijzen op de uiterst gecompliceerde federale structuur van hun land, een moeilijkheid die nog eens wordt versterkt doordat de Belgische kiezer recent regelmatig een partij de grootste maakt, die uit is op uiteenvallen van de federatie (N-VA). Dat excuus heeft de Nederlandse politiek niet.
De voorbereiding van wetgeving door de Tweede Kamer, terug naar het oude?
Authors: van Gennip T.E.J.H. 
Published: August 2022

De voorbereiding van wetgeving door de Tweede Kamer, terug naar het oude?
Eind december 2021 bracht de Werkgroep Versterking functies Tweede Kamer een rapport uit. Zij komt daarin met interessante ideeën over de medewetgevende, controlerende en vertegenwoordigende functie van de Tweede Kamer. Deze bijdrage gaat alleen over de aanbevelingen van de Werkgroep inzake de medewetgevende functie. Nog concreter gaat het over de voorbereidingsfase van de wetgevingsprocedure in de Tweede Kamer. De Werkgroep Versterking functies Tweede Kamer (hierna: de Werkgroep) komt op dit punt tot de stellingname dat er meer aandacht moet komen voor wetgeving.
GOVERNANÇA EM PROJETOS DE REDUÇÃO DA POBREZA RURAL: O CASO DE MARAPANIM – PARÁ
Authors: Dos Santos Brenda Cordovil Corrêa , Herreros Mário Miguel Amin Garcia , Ravena Nirvia 
Published: August 2022

Esta pesquisa objetiva analisar a governança no Projeto de Redução da Pobreza Rural (Pará Rural) co-financiado pelo Banco Mundial e executado pelo Governo do Estado do Pará em Marapanim-PA. Para tal foi avaliada a governança, a ação coletiva no desenvolvimento do projeto e como se derão as relações do projeto com o ambiente, com foco no processo constitutivo das instituições e sua influência na formulação estratégica. Quanto à metodologia, trata-se de uma pesquisa de natureza aplicada, com objetivos exploratórios, com abordagem qualitativa e tem como estratégia de pesquisa o estudo de caso. A pesquisa concluiu que a estratégia e a forma como a ação coletiva ocorre influenciam diretamente na governança, sendo ela resultado desses fatores.
History of New Mexico Geological Society 1947-1968
Authors: Northrop Stuart A. 
Published: August 2022

The compilation of this history was not a self-imposed task. In an unguarded moment back in 1962, I accepted the commission at the request of the Executive Committee. Special Publication No. 2, A history of the New Mexico Geological Society, was announced as being in preparation in the list of Society publications in the 15th guidebook (1964).I cannot refrain from noting that this is by far the shortest span of history I have attempted to cover. Over many years of teaching historical geology, paleontology, and stratigraphy, the minerals, rocks, and fossils involved go back more than a billion years. Man's inquiries about these materials -- the history of geology --started with the Greeks several centuries B. C. In my searching for early records of minerals in New Mexico, I have gone back to Spanish explorations of 1540 --more than four centuries ago. In checking early discoveries of fossils in New Mexico, I found that written records began in 1841. In assembling the history of New Mexico earthquakes, I have gone back 113 years to 1855 (Northrop, 1947, p. 1268). The shortest span of history hitherto attempted has been that of the University of New Mexico Department of Geology, which began with Clarence Luther Herrick 71 years ago in 1897 (Northrop, 1966). Now we are considering a Society that is just 21 years old!
Evaluation of the colorimetric cyanmethemoglobin method and the automatical analyser for hemoglobin estimation
Authors: DIANA AROCKIA LOURDU , KRISHNAN VISHAKHA , POOJA S , MANIKANDAN VYSHNAV 
Published: August 2022

ABSTRACT
Hemoglobin estimation by cyanmethemoglobin method was carried out in the present study. The intensity of the color was measured by colorimeter and autoanalyser. The samples were collected from St Isabel’s Hospital, Chennai and estimation of hemoglobin was done in autoanalyser. The remaining sample was transported to Loyola Health Centre, Chennai and then estimation of hemoglobin was performed with colorimeter. The readings obtained from colorimeter and autoanalyser processed statistically and was compared. Results indicates the insignificant variation between the autoanalyser and colorimeter for estimation of Hemoglobin respectively. Autoanalyser detects more anemic cases than colorimetric method. However, in resource poor condition where laboratory cannot afford expensive autoanalyser, colorimeter can be used as a suitable alternative.
Keywords: Colorimeter, Autoanalyser, Hemoglobin.
Is Routine Therapeutic Drug Monitoring of Anti-Retroviral Agents Warranted in Children Living with HIV?
Authors: Tam Jennifer , Lau Elaine , Read Stanley , Bitnun Ari 
Published: August 2022

OBJECTIVE
The utility of routine therapeutic drug monitoring (TDM) in children living with HIV has not been extensively studied. The purpose of this study was to assess this strategy.

METHODS
This was a single-center, prospective observational study of routine TDM for protease inhibitors (PIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and integrase strand transfer inhibitors (INSTIs) in children living with HIV who were receiving antiretroviral therapy (ART) between February and December 2014. Outcome measures included the proportion of serum antiretroviral (ARV) medication concentrations in the therapeutic range (target values extrapolated from adult data) and the effect of serum concentrations on virologic control, medication adherence, and toxicity.

RESULTS
Forty-eight children with a median age of 13 years (interquartile range, 3–18) were included. Median viral load (VL) and CD4% were &lt;40 copies/mL (range, &lt;40–124) and 37.4% (range, 8.4–47.9), respectively. Adherence was considered excellent in 95.8% of patients. Of the 50 serum trough concentrations (PI n = 19 [38%]; NNRTI n = 27 [54%]; INSTI n = 4 [8%]), 66% (n = 33) were in the therapeutic range, 12% (n = 6) were subtherapeutic, and 22% (n = 11) were supratherapeutic. There was no statistically significant correlation between serum ARV concentrations and patient demographics, VL, CD4%, or adherence. No clinically significant adverse events were noted. One dose adjustment was made for a subtherapeutic serum raltegravir concentration, likely attributable to interaction with ritonavir.

CONCLUSIONS
This study does not support routine TDM in healthy children living with HIV who are well controlled on antiretroviral medication regimens. A more targeted strategy, such as when adherence is questioned or when there are suspected drug interactions, may be more appropriate.
El Derecho de Vivir en Paz: quem matou Victor Jara?
Authors: Genaro Luís Felipe Machado de 
Published: August 2022

A resenha em questão traz o olhar e perspectivas de um historiador das canções engajadas latino-americanas sobre o documentário "Massacre no Estádio", do diretor norte-americano Bent-Jorgen Perlmutt, estreado no streaming Netflix, em 2019, sobre os últimos dias de vida do cantor e compositor chileno Victor Jara.
The Effect of Gestational Weight Gain on Low Birth Weight, Case-Control Study in Northeast Amhara Regional State, Ethiopia, 2019
Authors: Mezen Muluemebet Kassa , Lemlem Getasew Assefa , Biru Yemisrach Belete 
Published: August 2022

Background: Intrauterine growth and development are one of the most vulnerable periods in the human life cycle that contribute to appropriate fetal development. Therefore, this study aimed to assess the effect of gestational weight on low birth weight (LBW).
Methods: A case-control study was conducted from June 30, 2018, to January 1, 2019, in seven governmental hospitals in the northeast Amhara region on 451 participants(150 cases and 301 controls).
Results: Inadequate gestational weight gain increases the risk of LBW by four times (AOR: 4.2, 95% CI: 2.4, 6.4). Anemic mothers were 3 times (AOR: 3.2, 95%CI: 2.5, 5.1) more likely to give birth to LBW newborns than non-anemic women. Mothers with a height of less than 150 cm were 2 times more likely to deliver low birth weight babies than their counterparts (AOR:2.1, 95% CI: 1.5,4.4). The odds of LBW delivery were 3.5 times (AOR: 3.5, 95% CI: 2.3, 5.3) higher for mothers with poor dietary diversity than for mothers with good dietary diversity.
Conclusion: Inadequate gestational weight gain during pregnancy was found to be a risk factor for LBW. Additionally, anemia, short stature, and poor dietary diversity were also risk factors for LBW. Therefore, selectively targeted interventions such as improving maternal nutrition, anemia prevention, and proper maternal weight monitoring during pregnancy are needed.
Users’ needs for a digital smoking cessation application and how to address them: A mixed-methods study
Authors: Albers Nele , Neerincx Mark A. , Penfornis Kristell M. , Brinkman Willem-Paul 
Published: August 2022

BackgroundDespite their increasing prevalence and potential, eHealth applications for behavior change suffer from a lack of adherence and from dropout. Advances in virtual coach technology provide new opportunities to improve this. However, these applications still do not always offer what people need. We, therefore, need a better understanding of people’s needs and how to address these, based on both actual experiences of users and their reflections on envisioned scenarios.MethodsWe conducted a longitudinal study in which 671 smokers interacted with a virtual coach in five sessions. The virtual coach assigned them a new preparatory activity for quitting smoking or increasing physical activity in each session. Participants provided feedback on the activity in the next session. After the five sessions, participants were asked to describe barriers and motivators for doing their activities. In addition, they provided their views on videos of scenarios such as receiving motivational messages. To understand users’ needs, we took a mixed-methods approach. This approach triangulated findings from qualitative data, quantitative data, and the literature.ResultsWe identified 14 main themes that describe people’s views of their current and future behaviors concerning an eHealth application. These themes relate to the behaviors themselves, the users, other parties involved in a behavior, and the environment. The most prevalent theme was the perceived usefulness of behaviors, especially whether they were informative, helpful, motivating, or encouraging. The timing and intensity of behaviors also mattered. With regards to the users, their perceived importance of and motivation to change, autonomy, and personal characteristics were major themes. Another important role was played by other parties that may be involved in a behavior, such as general practitioners or virtual coaches. Here, the themes of companionableness, accountability, and nature of the other party (i.e., humanvsAI) were relevant. The last set of main themes was related to the environment in which a behavior is performed. Prevalent themes were the availability of sufficient time, the presence of prompts and triggers, support from one’s social environment, and the diversity of other environmental factors. We provide recommendations for addressing each theme.ConclusionsThe integrated method of experience-based and envisioning-based needs acquisition with a triangulate analysis provided a comprehensive needs classification (empirically and theoretically grounded). We expect that our themes and recommendations for addressing them will be helpful for designing applications for health behavior change that meet people’s needs. Designers should especially focus on the perceived usefulness of application components. To aid future work, we publish our dataset with user characteristics and 5,074 free-text responses from 671 people.
CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma via the PI3K/AKT signaling pathway
Authors: Chai Songling , Wen Zhihao , Zhang Rongxin , Bai Yuwen , Liu Jing , Li Juanjuan , Kongling Wenyao , Chen Weixian , Wang Fu , Gao Lu 
Published: August 2022

Background
CC chemokine receptor 9 (CCR9), an organ-specific chemokine receptor, interacts with its exclusive ligand CCL25 to promote tumor proliferation and metastasis. However, the effect of CCR9 on salivary adenoid cystic carcinoma (SACC) malignant behavior remains unknown. This study aimed to investigate the specific molecular mechanism by which CCR9/CCL25 modulates malignant progression in SACC.

Methods
Immunohistochemistry staining and RT–qPCR analyses were performed to detect the correlation of CCR9 expression and tumor progression-associated markers in SACC. In vitro, SACC cell proliferation and apoptosis were evaluated using Cell Counting Kit-8 and colon formation, and cell migration and invasion were detected by wound healing and transwell assays. Vercirnon was used as an inhibitor of CCR9, and LY294002 was used as an inhibitor of the PI3K/AKT pathway in this study. Western blot and RT–qPCR assays were carried out to measure the downstream factors of the interaction of CCL25 and CCR9. The effect of CCL25 on the development of SACC in vivo was examined by a xenograft tumor model in nude mice following CCL25, Vercirnon and LY294002 treatment.

Results
CCR9 was highly expressed in SACC compared with adjacent salivary gland tissues, and its level was associated with tumor proliferation and metastases. CCL25 enhanced cell proliferation, migration, and invasion through its interaction with CCR9 and exerted an antiapoptotic effect on SACC cells. Targeting CCR9 via Vercirnon significantly reduced the phosphorylation level of AKT induced by CCL25. CCL25/CCR9 could activate its downstream factors through the PI3K/AKT signaling pathway, such as cyclin D1, BCL2 and SLUG, thus promoting SACC cell proliferation, antiapoptosis, invasion and metastasis. The in vivo data from the xenograft mouse models further proved that CCL25 administration promoted malignant tumor progression by activating the PI3K/AKT pathway.

Conclusion
The interaction of CCL25 and CCR9 promotes tumor growth and metastasis in SACC by activating the PI3K/AKT signaling pathway, offering a promising strategy for SACC treatment.
An Qualitative Research on Regional Brand Image and Its Effect on Purchase Intention
Authors: Fan Mo , Weiming Chee 
Published: August 2022

Purpose: The purpose of this paper is to examine the origin image of selected regional brands and its effect on consumer’s purchase intention. It also seeks to examine the importance of regional brand and finally, define consumer preference for selected agricultural product, offering marketing strategies and practices for promoting regional brands of agricultural product.
Design/Methodology/Approach: Taking a semi-structured focus group interview to provide the researcher with the opportunity to gain further understanding of the participants’ experiences in purchasing regional agricultural products. The length of the interviews is approximately 1.5 hours for each of the three groups of five people. The fifteen selected interviewees familiar with regional brands as well as agricultural product. Among them are brand managers, marketing executives, industry experts, retailers and consumers. A content analysis was conducted after interviews completed and transcribed.
Findings: The major findings of this research show that the dimension of origin image include region's economic, humanistic, industrial, typical enterprise and product itself. It also has a significant impact on consumers’ purchase intention, especially for the regional brand of agricultural product. Interestingly, if origin is clearly indicated on the label, the sales of the agricultural products would be greater, but it plays the moderate role rather than key factor.
Practical/Managerial Implications: This research suggests that regional brand image is important in the eyes of a potential consumer in that it could to some extent induce the consumer to purchase the agricultural product. The results of the research provide insights into regional branding strategies to better manage and design marketing practices and activities to increase consumer preferences.
Originality/Value: This paper is of value to academic researcher, agricultural product retailer, brand manager and regional brand associations alike as it synthesis the factors of country-of-origin effect in the consumer purchasing process and the impact of country-of-origin as a agriculture marketing strategy.
Barriers of Utilizing an Electronic Health System in Sub-Saharan Africa
Authors: Kuffour Emmanuel Anning 
Published: August 2022

Objective: Accessing data information of patients has been a challenge for years due to the use of paper recording, some essential data are either lost or mistakenly thrown away and cannot be retrieved. This is a major public health concern to ensure the effective provision of healthcare to patients. The purpose of the study focuses on the barriers to utilizing an electronic health system in sub-Saharan Africa.
Methods: A systematic review was carried out with the aid of online research journal websites as well as other in-context articles. While conducting this study, the keywords in the search query were directed toward the barriers to the implementation of an electronic health system in Sub-Saharan Africa. Areas noted in relation to this study were the use of electronic health systems among health professionals. Therefore, there was a linkage of papers pointing out the barriers hindering the implementation of the e-health system.
Results: According to Kemper and other researchers more than half (58.1%) of the physicians without an electronic medical system doubt that an electronic medical system can improve patient care or clinical outcomes. In Shachak’s research, where this issue was considered, 92% of physicians felt electronic medical system use did disturb communication with their patients.
Conclusion: The findings of this study can be used as an overview of barriers that physicians might possibly see in the electronic medical system implementation process and, as such, could be valuable for electronic medical system policymakers and implementers. The study indicates that policymakers should be more aware of the reality that removing technical, financial, and legal barriers is not sufficient to ensure the realization of the promises of electronic medical system.
Design and Validation of a Scale to Measure Attitudes towards Abortion Legislation; Application of Explanatory and Confirmatory Factor Analysis
Authors: Suranga M. Suchira , Silva Kalinga Tudor , Senanayake Lakshman 
Published: August 2022

General societal attitudes on induced abortion can influence the health sector policy response towards providing safe abortion services. This study aimed to develop a scale and evaluate the validity and reliability to measure public attitudes towards abortion legislation. An scale was developed by adapting existing scales and finalized with experts’ opinions. An interview schedule was administered among 728 adults residents in Colombo, Sri Lanka. Validity and reliability were tested after performing Explanatory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA).
The finalized scale contained 8 items and 2 factors named “Attitudes towards soft reasons” and “Attitudes towards hard reasons”. The two factors explained 71% of the total variability. The CFA showed a good model fit. Composite Reliability for the first and second factors were 0.938 and 0.890 respectively. The scale’s internal consistency correlation coefficient was at the acceptable level (Cronbach’s alpha = 0.923 and 0.850, McDonald’s omega = 0.915 and 0.863 for the first and second factors respectively). The Average Variance Extracted of the two factors were 0.792 and 0.671 whereas the Maximum Shared Squared Variance was 0.054. The correlation between the two factors was 0.23.
The scale is proved to have high validity and reliability to measure the public attitudes towards abortion legislation.
Clinical and Genetic Risk Factors for Acute Incident Venous Thromboembolism in Ambulatory Patients With COVID-19
Authors: Xie JunQing , Prats-Uribe Albert , Feng Qi , Wang YunHe , Gill Dipender , Paredes Roger , Prieto-Alhambra Dani 
Published: August 2022

ImportanceThe risk of venous thromboembolism (VTE) in ambulatory COVID-19 is controversial. In addition, the association of vaccination with COVID-19–related VTE and relevant clinical and genetic risk factors remain to be elucidated.ObjectiveTo quantify the association between ambulatory COVID-19 and short-term risk of VTE, study the potential protective role of vaccination, and investigate clinical and genetic risk factors for post–COVID-19 VTE.Design, Setting, and ParticipantsThis population-based cohort study of patients with COVID-19 from UK Biobank included participants with SARS-CoV-2 infection that was confirmed by a positive polymerase chain test reaction result between March 1, 2020, and September 3, 2021, who were then propensity score matched to COVID-19–naive people during the same period. Participants with a history of VTE who used antithrombotic drugs (1 year before index dates) or tested positive in hospital were excluded.ExposuresFirst infection with SARS-CoV-2, age, sex, ethnicity, socioeconomic status, obesity, vaccination status, and inherited thrombophilia.Main Outcomes and MeasuresThe primary outcome was a composite VTE, including deep vein thrombosis or pulmonary embolism, which occurred 30 days after the infection. Hazard ratios (HRs) with 95% CIs were calculated using cause-specific Cox models.ResultsIn 18 818 outpatients with COVID-19 (10 580 women [56.2%]; mean [SD] age, 64.3 [8.0] years) and 93 179 matched uninfected participants (52 177 women [56.0%]; mean [SD] age, 64.3 [7.9] years), the infection was associated with an increased risk of VTE in 30 days (incidence rate of 50.99 and 2.37 per 1000 person-years for infected and uninfected people, respectively; HR, 21.42; 95% CI, 12.63-36.31). However, risk was substantially attenuated among the fully vaccinated (HR, 5.95; 95% CI, 1.82-19.5; interaction P = .02). In patients with COVID-19, older age, male sex, and obesity were independently associated with higher risk, with adjusted HRs of 1.87 (95% CI, 1.50-2.33) per 10 years, 1.69 (95% CI, 1.30-2.19), and 1.83 (95% CI, 1.28-2.61), respectively. Further, inherited thrombophilia was associated with an HR of 2.05 (95% CI, 1.15-3.66) for post–COVID-19 VTE.Conclusions and RelevanceIn this population-based cohort study of patients with COVID-19, ambulatory COVID-19 was associated with a substantially increased risk of incident VTE, but this risk was greatly reduced in fully vaccinated people with breakthrough infection. Older age, male sex, and obesity were clinical risk factors for post–COVID-19 VTE; factor V Leiden thrombophilia was additionally associated with double the risk, comparable with the risk of 10-year aging. These findings may reinforce the need for vaccination, inform VTE risk stratification, and call for targeted VTE prophylaxis strategies for unvaccinated outpatients with COVID-19.