bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbiota intestinal en pacientes con Diabetes Mellitus: Análisis de la evidencia actual. Revisión sistemática
Authors: Martinez Colarossi Gianfranco Jose , Melean Lopez Zuleibis Lucia De La Chiquinquira , Carrera Viñoles Fernando Javier 
Published: April 2022

La microbiota intestinal corresponde al conjunto de microorganismos que se encuentran como entes comensales del intestino, principalmente formada por bacterias Gram negativas, cuyas proporciones parecen estar asociadas con eventos inmunopatológicos que la correlacionan con enfermedades metabólicas como Diabetes Mellitus tipo 1 y 2 por lo que se analiza la evidencia actual sobre la microbiota intestinal y su relación con los dos tipos principales de Diabetes Mellitus, se indaga sobre mecanismos fisiopatológicos mediados principalmente por Lipopolisacáridos de membrana y su expresión dentro de la patogénesis de la Diabetes Mellitus tipo 1 y 2. Se realiza una revisión narrativa de 34 artículos posterior a una selección inicial de 50 a través de buscadores como PubMed, Google Scholar, CrossRef y Scielo, asociados con Microbiota Intestinal y Diabetes Mellitus tipo 1 y 2. Se relaciona principalmente con Bacteroides spp. como bacilo diabetogénico vinculado a mecanismos de autoinmunidad descritos en Diabetes Mellitus tipo 1 y en menor medida a resistencia a la insulina en Diabetes Mellitus tipo 2. Se vinculan altas concentraciones de Akkermansia muciniphila como factor protector en el desarrollo de Diabetes Mellitus tipo 2. Se concluye que dentro de la bibliografía consultada existe una importante correlación entre la microbiota intestinal y el desarrollo de enfermedades metabólicas, conllevando a estados disbiosis que producen manifestaciones patológicas de enfermedades multifactoriales ya conocidas como lo son la Diabetes Mellitus tipo 1 y 2.
Projectbesluit? Nee, dank je
Authors: ten Heuw E.W. (Ewout) 
Published: April 2022

Projectbesluit? Nee, dank je
Auteur gaat in op het kerninstrument projectbesluit en staat stil bij de vraag of het projectbesluit de ook destijds veronderstelde logische opvolger kan zijn van het projectplan op grond van de Waterwet. Hij geeft een interessante inkijk in de praktijk van de waterbeheerder, met name hoe deze projecten voorbereidt en beschrijft hoe besluitvorming over waterschapsprojecten nu plaatsvindt, hoe dat met toepassing van het projectbesluit het geval zal zijn onder de Omgevingswet, en of een vergunning eigen werken een alternatief kan zijn voor het projectbesluit.
ALK Translocation in ALK-Positive Mesenchymal Tumors: Diagnostic and Therapeutic Insights
Authors: Jung Minsun , Moon Kyung Chul , Bae Jeongmo , Kim Tae Min , Kim Miso , Jeon Yoon Kyung , Lee Cheol 
Published: April 2022

Context.—
A wide spectrum of mesenchymal tumors harboring ALK gene rearrangements has been identified outside the archetypal example of ALK-positive inflammatory myofibroblastic tumors.

Objective.—
To evaluate the molecular pathology of unusual ALK-positive mesenchymal tumors and their response to ALK-targeted treatments.

Design.—
Seven patients with ALK-positive mesenchymal tumors, including inflammatory epithelioid cell sarcoma, undifferentiated sarcoma, histiocytic neoplasm, smooth muscle tumor of uncertain malignant potential (STUMP), and atypical fibrohistiocytic tumor, were included on the basis of aberrant ALK immunoexpression. Patients with inflammatory myofibroblastic tumors were excluded from the study. ALK gene rearrangement was investigated either by fluorescence in situ hybridization or next-generation sequencing.

Results.—
ALK was immunolabeled in all patients, diffusely (≥50%) in 6 patients and partially (10%–50%) in 1 patient. ALK gene rearrangement was discovered in 5 of the 6 available patients. The 3′-partners of ALK fusion were identified in 3 of 4 investigated patients as follows: PRKAR1A-ALK (ALK-positive histiocytic neoplasm), TNS1-ALK (STUMP), and KIF5B-ALK (ALK-positive atypical fibrohistiocytic tumor). We failed to discover ALK translocation in 1 patient with ALK-positive inflammatory epithelioid cell sarcoma. However, transcriptomic investigation showed that this tumor was significantly enriched with ALK-related pathways, which suggested activation of ALK through a nontranslocation pathway, as a constitutive oncogenic mark in this tumor. ALK-targeted inhibitors, which were administered to 3 patients with metastatic diseases, achieved partial remission in 1 patient with ALK-positive inflammatory epithelioid cell sarcoma and stable disease in patients with ALK-positive undifferentiated sarcoma and STUMP.

Conclusions.—
Molecular investigation of ALK-positive mesenchymal neoplasms could allow for an accurate diagnosis and personalized treatment.
Jornalismo de moda: O slow fashion como notícia nos blogs especializados
Authors: Sousa Jailson Oliveira , Teixeira Juliana Fernandes , Silveira Icléia , Goulart Henrique de Souza 
Published: April 2022

O objetivo deste artigo é analisar as notícias publicadas sobre o slow fashion em websites especializados no jornalismo de moda e identificar como o jornalismo especializado de/em moda vem sendo um importante vetor de informação e conscientização ética sobre o consumo responsável nas sociedades ocidentais do século XXI. Para tanto, por meio de pesquisa básica, qualitativa e descritiva, empreendeu-se uma análise de conteúdo comparativa de três blogs especializados em moda: (I) Moda sem crise, (II) Modefica e (III) Stylo urbano, a partir de notícias e reportagens sobre o movimento slow fashion. Os resultados apontaram que, apesar desses websites apresentarem majoritariamente tendências de moda como looks do dia e cartelas de cores ditados por blogueiras, estes se revelam como frutíferos espaços midiáticos para abordagens mais conscientes e alternativas sustentáveis nos conteúdos de moda apresentados.
Um panorama do status de conservação de espécies de Priapulida e Onychophora no Brasil
Authors: Silva Clécio Danilo Dias da 
Published: April 2022

Este trabalho teve como objetivo realizar um panorama das espécies dos filos Priapulida e Onychophora ameaçadas de extinção, bem como, discutir o estado de conservação de seus represetantes. Para isso utilizou-se de dados brutos presentes no “Livro Vermelho da Fauna Brasileira ameaçada de Extinção”, onde as espécies dos grupos estavam listadas. Por meio da exploração e análise deste material, constatou-se que grande parte das espécies dos onicóforos e priapúlideos estão inclusos na categoria Dados Insuficientes (DD) da International Union for Conservation of Nature (IUCN). Essa situação evidencia que, apesar do avanço nas pesquisas envolvendo aspectos taxonômicos e filogenéticos para estes filos, verifica-se um número ínfimo de estudos que exploram e discutem seus aspectos comportamentais, ecológicos e conservacionistas, servindo como um propulsor para o desenvolvimento e efetivação de pesquisas que contribuam para a conservação dos filos Priapulida e Onychophora no Brasil e no mundo.
Ritualstruktur og ritualklassifikation 2.0
Authors: Fibiger Marianne Qvortrup 
Published: April 2022

ABSTRACT: In 1992, Jens Peter Schjødt wrote a very informative article in Religionsvidenskabeligt Tidsskrift on the structure and classification of rituals. The article introduces to some of the basic features of rites of passage and also gives suggestions to how these can be classified into different types. A focal point in this connection is to understand the ritual as either direct or indirect communication respectively, and its presumed efficacy. Here it is particularly important to look at the “before” and the “after” of the ritual. From my point of view, the article is a really good starting point for introducing the meaning(s) of rituals to students, especially with a few additions. The aim of the present article is firstly to give a systematic overview of JPS’ main arguments with a few additional comments, secondly to broaden out the communicative perspective. This is partly done with the addition of Roy Rappaports differentiation between auto- and allo-communication and my own suggested category called exterioris communication.
RESUME: I 1992 skrev Jens Peter Schjødt en meget oplysende artikel om ritualstruktur og ritualklassifikation i Religionsvidenskabeligt Tidsskrift. I artiklen introduceres læseren ikke kun for nogle af de grundlæggende træk ved overgangsritualer, men også for forslag til, hvordan disse kan klassificeres i forskellige typer. Et centralt omdrejningspunkt er, at se på ritualet som henholdsvis indirekte og direkte kommunikation og på dets tillagte effikacitet. Her er det særligt interessant at se på ritualets før- og efter. Fra min synsvinkel er artiklen rigtig god at bruge når ritualet og dets forskellige betydninger skal introduceres for nye studerende. Dog gerne med et par enkelte tilføjelser. Målet med nærværende artikel er først at give en systematisk fremstilling af JPS' hovedpointer, tilknyttet et par forslag til uddybning, derefter at brede det kommunikative perspektiv ud. Det gøres bl.a. ved inddragelse af Roy Rappaports skelnen imellem autoog allo-kommunikation og min egen tilføjelse, som jeg kalder exterioris-kommunikation.
Imaging Features of Calcium Pyrophosphate Deposition Disease: Consensus Definitions From an International Multidisciplinary Working Group
Authors: Tedeschi Sara K. , Becce Fabio , Pascart Tristan , Guermazi Ali , Budzik Jean‐François , Dalbeth Nicola , Filippou Georgios , Iagnocco Annamaria , Kohler Minna J. , Laredo Jean‐Denis , Smith Stacy E. , Simeone F. Joseph , Yinh Janeth , Choi Hyon , Abhishek Abhishek 
Published: April 2022

ObjectiveTo develop definitions for imaging features being considered as potential classification criteria for calcium pyrophosphate deposition (CPPD) disease, additional to clinical and laboratory criteria, and to compile example images of CPPD on different imaging modalities.MethodsThe American College of Rheumatology and European Alliance of Associations for Rheumatology CPPD classification criteria Imaging Advisory Group (IAG) and Steering Committee drafted definitions of imaging features that are characteristic of CPPD on conventional radiography (CR), conventional computed tomography (CT), dual‐energy CT (DECT), and magnetic resonance imaging (MRI). An anonymous expert survey was undertaken by a 35‐member Combined Expert Committee, including all IAG members. The IAG and 5 external musculoskeletal radiologists with expertise in CPPD convened virtually to further refine item definitions and voted on example images illustrating CR, CT, and DECT item definitions, with ≥90% agreement required to deem them acceptable.ResultsThe Combined Expert Committee survey indicated consensus on all CR definitions. The IAG and external radiologists reached consensus on CT and DECT item definitions, which specify that calcium pyrophosphate deposits appear less dense than cortical bone. The group developed an MRI definition and acknowledged limitations of this modality for CPPD. Ten example images for CPPD were voted acceptable (4 CR, 4 CT, and 2 DECT), and 3 images of basic calcium phosphate deposition were voted acceptable to serve as contrast against imaging features of CPPD.ConclusionAn international group of rheumatologists and musculoskeletal radiologists defined imaging features characteristic of CPPD on CR, CT, and DECT and assembled a set of example images as a reference for future clinical research studies.
All opinions are not equal: Toward a consensual approach to the development of drug policy
Authors: Wong Gabriel T. W. , Manning Matthew 
Published: April 2022

AbstractDrug policy has been subjected to much scrutiny from different stakeholder groups who present sometimes very different opinions on solutions to address a problem. Reconciling such differences, that are underpinned by both anecdotal and empirical evidence, is a priority yet to be fully achieved. In this study, we examine: (i) whether differences exist among actor groups regarding their perceived importance in policymaking; (ii) whether those who dominate the decision process value the input of laypeople or minority actors; and (iii) whether differences exist, with regard to i and ii, between study sites (i.e. Australia and Hong Kong) that have markedly different drug strategies. Overall, differential preference weightings between dominant groups reveal a strong influence of political orientation. Results suggest that decisions made by health professionals were regarded as the most important, while most of the respondent groups gave a low preference toward policy decisions made by law enforcers. Dominant groups also tend to discount the inputs of laypeople and other minority groups. Our study highlights the importance for policy actor groups to consider such a differential weighting of inputs when synthesising knowledge and gathering opinions for the development of drug policy.
Effect of Imaging Markers on Reperfusion Therapy in Basilar Artery Occlusion
Authors: Yan Shenqiang , Zhou Ying , Zhao Yuqi , Wang Feng , Tao Anyang , Zhou Lin , Pan Mengxiong , Zhong Genlong , Hu Lingzhi , Jiang Xuanfei , Mao Xinlei , Tang Huan , Wang Jianwei , Qian Shuxia , Sun Jingping , Gong Xiaoxian , Zhong Wansi , Lou Min ,   CASE II investigators
Published: April 2022

ObjectiveWe aimed to investigate the effectiveness of endovascular therapy (EVT) versus intravenous thrombolysis (IVT) in patients with basilar artery occlusion (BAO), based on the information of advanced imaging.MethodsWe analyzed data of stroke patients with radiologically confirmed BAO within 24 hours. BAO subjects were categorized into “top‐of‐the‐basilar” syndrome (TOBS) and other types. An initial infarct size of <70ml and a ratio of ischemic tissue to infarct volume of ≥1.8 was defined as “target mismatch.” The primary outcome was a good outcome, defined as a modified Rankin Scale score of 0 to 3 at 3 months. Propensity score adjustment and inverse probability of treatment weighting (IPTW) propensity score methods were used.ResultsAmong 474 BAO patients, 93 (19.6%) were treated with IVT prior to EVT, 91 (19.2%) were treated with IVT alone, 95 (20.0%) were treated with EVT alone, and 195 (41.1%) were treated with antithrombotic therapy. In IPTW analyses, we found no benefit of EVT over IVT for good outcome in either TOBS patients (odds ratio = 1.08, 95% confidence interval [CI] = 0.88–1.31) or those with other types (odds ratio = 1.13, 95% CI = 0.94–1.36). However, in patients with other types, if there existed a target mismatch, EVT was independently related to good outcome (odds ratio = 1.46, 95% CI = 1.17–1.81).InterpretationThe “target mismatch profile” seems to be a possible candidate selection standard of EVT for those with other types of BAO. Future studies should separate TOBS from other types of BAO, and try to use advanced imaging. ANN NEUROL 2022;92:97–106
Accelerating the Photocatalytic Atom Transfer Radical Addition Reaction Induced by Bi2O3 with Amines: Experiment and Computation
Authors: Riente Paola , Fianchini Mauro , Pericàs Miquel A. , Noël Timothy 
Published: April 2022

AbstractMetal oxide semiconductors are widely used in photocatalysis for the sustainable synthesis of fine chemicals and fuels. However, the mechanisms and the actual catalytically active species involved in these photocatalytic processes are not yet fully understood. Herein, we reveal that the addition of certain amines can effectively accelerate the photocatalytic atom transfer radical addition (ATRA) reaction by stabilizing a soluble Bi‐species formed through a reaction between Bi2O3 and diethyl bromomalonate using either N, N‐dimethylformamide (DMF) or dimethyl sulfoxide (DMSO) as a solvent. Moreover, thermodynamic calculations revealed that N, N, N’, N’‐tetramethylethylenediamine (TMEDA), and DMF yield the most stable complexes [(κ2‐TMEDA)2BiBr3], ultimately accelerating the formation of the targeted ATRA product.
Toward Economical and Sustainable Production of Renewable Plastic: Integrative System‐Level Analyses
Authors: Kim Hyunwoo , Kim Jiyong , Won Wangyun 
Published: April 2022

Abstract2,5‐Furandicarboxylic acid (FDCA) is one of the promising renewable plastic monomers enabling to address several environmental issues, instead of petroleum‐based terephthalic acid (TPA). In this study, an integrative process for the co‐production of FDCA and furfural as well as activated carbon was developed, and the economic feasibility and environmental sustainability for the proposed process were evaluated. In the proposed process, there were major four catalytic conversion reactions: (1) hydrolysis of biomass to its derivatives (cellulose, hemicellulose, and lignin), (2) dehydration of hemicellulose to furfural, (3) dehydration of cellulose to 5‐hydroxymethylfurfural (HMF), and (4) successive oxidation of HMF to FDCA. Particularly, a heat exchanger network coupled with a heat pump was established to minimize the utility consumption, thereby reducing 72 % of the heating requirement. Techno‐economic analysis revealed that the minimum selling price of FDCA was $1380 ton−1, which is comparable to that of petroleum‐based TPA ($1445 ton−1). Uncertainty analysis using the Monte Carlo simulation method was employed to quantify the risk associated with the unforeseen market condition. From the life‐cycle assessment, we observed that the proposed process is more environmentally sustainable than conventional TPA production in terms of climate change and fossil depletion metrics.
In vitro investigation of the effect of food texture, particle size, and viscosity on gastric disintegration and emptying
Authors: Kong Fanbin , Tran Do Duc Huy 
Published: April 2022

AbstractThe objective of this study was to investigate the influence of particle size, texture, and gastric viscosity on food gastric disintegration and emptying rates. In vitro dynamic gastric digestion was conducted for carrots using a dynamic gastric simulation model. The changes in the texture of carrots and other foods as indicated by bulk resistance, the percent solids emptied, and the particle size distribution were used as parameters to study disintegration kinetics and emptying patterns. The influence of viscosity on food emptying was studied on both indigestible particles (amberlite beads) and digestible solids (carrots). The results indicated medium‐size carrot particles (1.40–2.00 mm) had a greater disintegration and a higher amount of emptying rate when compared to larger (2.00–3.34 mm) and smaller (1.14–1.40 mm) carrot particles. A high correlation exists between the final bulk resistance after 120 min digestion and the amount of solids emptied. Increasing viscosity up to values 8.20 Pa·s improved the particle dispersion for amberlite and carrots and increased rates of solids emptying, while further increase in viscosity hindered emptying of amberlite and carrot solids. The variable emptying rates of both indigestible and digestible solids with viscosity were described with a mathematical model based on particle‐emptying coefficient.
Safety of microvascular free tissue transfer reconstruction of the head and neck in the setting of chronic pharmacologic immunosuppression
Authors: Wang Ray , Horwich Peter , Sandulache Vlad C. , Hernandez David J. , Hornig Joshua , Graboyes Evan M. , Liou Nelson E. , Skoner Judith , Haskins Angela D. , Ranasinghe Viran , Day Terry A. , Sturgis Erich M. , Huang Andrew T. 
Published: April 2022

AbstractBackgroundPatients on chronic pharmacologic immunosuppressive therapy are at increased risk of wound infection and complications after surgery. There is a paucity of data examining perioperative complications after microvascular free tissue transfer (MVFTT) reconstruction of the head and neck in this patient population.MethodsRetrospective cohort study performed at two tertiary referral centers between August 2016 and May 2020.ResultsNine hundred and seventy‐nine patients underwent MVFTT during the study period; of these 47 (5%) patients were taking chronic immunosuppressive medications. The most common indications for immunosuppression were solid organ transplant and autoimmune disease. Fourteen (30%) patients had surgical complications within 30 days of surgery: 8 (17%) wound dehiscences, 6 (12%) hematomas, and 2 (4%) surgical site infections. There was one total and one partial flap failure with a 30‐day reoperation rate of 4%.ConclusionsMVFTT of the head and neck appears to be safe in patients on chronic pharmacologic immunosuppression.
Position paper on critical care pharmacy services (executive summary): 2020 update
Authors: Lat Ishaq , Paciullo Christopher , Daley Mitchell J. , MacLaren Robert , Bolesta Scott , McCann Jennifer , Stollings Joanna L. , Gross Kendall , Foos Sarah A. , Roberts Russel J. , Acquisto Nicole M. , Taylor Scott , Bentley Michael , Jacobi Judith , Meyer Tricia A. 
Published: April 2022

AbstractObjectivesTo provide a multiorganizational statement to update the statement from a paper in 2000 about critical care pharmacy practice and makes recommendations for future practice.DesignThe Society of Critical Care Medicine, American College of Clinical Pharmacy Critical Care Practice and Research Network, and the American Society of Health‐Systems Pharmacists convened a joint task force of 15 pharmacists representing a broad cross‐section of critical care pharmacy practice and pharmacy administration, inclusive of geography, critical care practice setting, and roles. The Task Force chairs reviewed and organized primary literature, outlined topic domains, and prepared the methodology for group review and consensus. A modified Delphi method was used until consensus (>66% agreement) was reached for each practice recommendation. Previous position statement recommendations were reviewed and voted to either retain, revise, or retire. Recommendations were categorized by level of ICU service to be applicable by setting, and grouped into five domains: patient care, quality improvement, research and scholarship, training and education, and professional development.Main resultsThere are 82 recommendation statements: forty‐four original recommendations and 38 new recommendation statements. Thirty‐four recommendations were made for patient care, primarily relating to critical care pharmacist duties and pharmacy services. In the quality improvement domain, 21 recommendations address the role of the critical care pharmacist in patient and medication safety, clinical quality programs, and analytics. Nine recommendations were made in the domain of research and scholarship. Ten recommendations are in the domain of training and education and eight recommendations regarding professional development.ConclusionsThe statements recommended by this taskforce delineate the activities of a critical care pharmacist and the scope of pharmacy services within the ICU. Effort should be made from all stakeholders to implement the recommendations provided, with continuous effort toward improving the delivery of care for critically ill patients.