bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strain-ultrasensitive surface wrinkles for visual wearable optical sensor
Authors: Ma Tianjiao , Chen Shuai , Li Jin , Yin Jie , Jiang Xuesong 
Published: February 2022

Abstract
Wearable tactile sensors have found widespread applications in human health monitoring, motion monitoring, human-machine interaction, and artificial prostheses. Herein, we demonstrate a new and feasible strategy for wearable optical sensors based on surface wrinkles ultrasensitive to strain using a bilayer wrinkling system, in which the sensing mechanism is different from that of the traditional electrical sensors. The strain (\(\overrightarrow{S}\left(\epsilon , {\theta }_{S}\right)\)), the wrinkled topography (\(\overrightarrow{W}\left(A, {\theta }_{W}\right)\)), and the reflected optical signal (\(\overrightarrow{O}\left(\delta , {\theta }_{O}\right)\)) functions are correlated with each other, allowing simultaneous measurement of strain magnitude and direction due to the vector property of optical signals. In addition, interactively visualized detection of slight strain has been achieved by conspicuous structural color change, successfully amplifying the strain signal owing to the ultra-sensitivity of wrinkles and the nonlinearity of optical signal. The sensor also exhibits electrical safety and immunity to electromagnetic interference, and thus may find potential applications in detecting various complex slight strains, such as subtle human motion or object deformation.
Digital finance and greener emissions: An empirical analysis of cities in China
Authors: Zhou Cai , Zhou Jinghong 
Published: February 2022

Abstract
We match the city-level finance digitization data from the Peking University digital financial inclusion index with the industrial pollution emissions information to study the relationship between digital finance and industrial pollution emissions. After alleviating endogenous problems with our instrument variable, we found that the development of digital finance significantly mitigates industrial pollution emissions, and the coverage and depth of digital finance also have a significant impact on industrial pollution emissions mitigation. We explain the mechanism through green personal finance and individual awareness. First, green finance programs provided on Alipay encourage greener emissions. Second, digital finance directly affects individuals’ environmental awareness and daily behaviors. Our empirical results show an average of 17.3% decrease in the industrial pollution emissions caused by digital finance.
WITHDRAWN: Salinity stress effects on growth and performance of drip-irrigated sweet potato varieties under the Mediterranean conditions
Authors: Doganay Kivanc Hayri , Kurunc Ahmet , Dincer Cuneyt 
Published: February 2022

Abstract
There is numerous scientific research on yield response of different sweet potato varieties under salinity stress, but no studies on the Koganesengan and Beniazuma varieties have been found in the literature. The aim of this study was to investigate the effects of irrigation salinity levels on growth, yield and quality parameters of these two sweet potato varieties under drip irrigation. Salinity levels had a substantial impact on some growth and yield parameters of ‘Beniazuma’, but not on those of ‘Koganesengan’. Irrigation salinity levels only influenced the crude fiber content and antioxidant activity of ‘Koganesengan’ and ash, starch, ß-carotene, and ascorbic acid contents of ‘Beniazuma’. Some growth and yield quality parameters showed significant differences between varieties under salinity level(s), and all yield parameters (except dry vine yield) only under control treatment. Under the same salt stress levels, the values of the examined parameters were greater in ‘Beniazuma’ than in ‘Koganesengan’. The salinity threshold and slope values, on the other hand, suggest that ‘Beniazuma’ is more vulnerable to salt stress than ‘Koganesengan’. As a result, sweet potato growers in the Mediterranean region should consider both the salt response and the productivity of these sweet potato varieties under drip irrigation with saline water.
Validation of an electronic frailty index with electronic health records: eFRAGICAP index
Authors: Pernas Francesc Orfila , Carrasco-Ribelles Lucía A. , Abellana Rosa , Roso-Llorach Albert , Cegri Francisco , Reyes Carlen , Violán Concepción 
Published: February 2022

Abstract
Objective: To create an electronic frailty index (eFRAGICAP) using electronic health records (EHR) in Catalunya (Spain) and assess its predictive validity with a two-year follow-up of the outcomes: homecare need, institutionalization and mortality in the elderly. Additionally, to assess its concurrent validity compared to other standardized measures: the Clinical Frailty Scale (CFS) and the Risk Instrument for Screening in the Community (RISC).Methods: The eFRAGICAP was based on the electronic frailty index (eFI) developed in United Kingdom, and includes 36 deficits identified through clinical diagnoses, prescriptions, physical examinations, and questionnaires registered in the EHR in of primary health care centres (PHC). All subjects >65 assigned to a PHC in Barcelona on 1st January, 2016 were included. Subjects were classified according to their eFRAGICAP index as: fit, mild, moderate or severe frailty. Predictive validity was assessed comparing results with the following outcomes: institutionalization, homecare need, and mortality at 24 months. Concurrent validation of the eFRAGICAP was performed with a sample of subjects (n=333) drawn from the global cohort and the CFS and RISC. Discrimination and calibration measures for the outcomes of institutionalization, homecare need, and mortality and frailty scales were calculated. Results: 253,684 subjects had their eFRAGICAP index calculated. Mean age was 76.3 years (59.5% women). Of these, 41.1% were classified as fit, and 32.2% as presenting mild, 18.7% moderate, and 7.9% severe frailty. The mean age of the subjects included in the validation sample (n=333) was 79.9 years (57.7% women). Of these, 12.6% were classified as fit, and 31.5% presented mild, 39.6% moderate, and 16.2% severe frailty. Regarding the outcome analyses, the eFRAGICAP was good in the detection of subjects who were institutionalized, required homecare assistance, or died at 24 months (c-statistic of 0.841, 0.853, and 0.803, respectively). eFRAGICAP was also good in the detection of frail subjects compared to the CFS (AUC 0.821) and the RISC (AUC 0.848).Conclusion: The eFRAGICAP has a good discriminative capacity to identify frail subjects compared to other frailty scales and predictive outcomes.
A perspective of matrix metalloproteases gene expression profile revealed by pan-cancer transcriptome and single cell data
Authors: Tan Jinxiang , Wang Linbang , Gao Yidan , Li Zhao , Wang Yuanyuan , Wang Lu 
Published: February 2022

Abstract
Background: Matrix metalloproteases (MMPs) are encoded by a family of genes that are related to cancer progression, and the overexpression of most MMP genes in cancers is associated with the promotion of invasion, angiogenesis, and immune surveillance avoidance. However, the expression patterns of all MMP genes at the transcriptome and single-cell levels have not been investigated from a pan-cancer perspective. Methods: The Cancer Genome Atlas transcriptome and single-cell sequencing pan-cancer data from the Gene Expression Omnibus were used in the present study to examine the expression patterns of these genes. The MMP-based diagnostic model was constructed using least absolute shrinkage and selection operator regression analysis. Tumors were classified into high and low score MMP groups using ssGSEA. Single-cell data were analyzed using the Seurat R package, and MMP gene expression was validated using quantitative real-time polymerase chain reaction.Results: MMP1, MMP11, and MMP12 expression was upregulated in almost all cancers. MMP19 and MMP27 expression was significantly downregulated in eight to nine cancer types. Correlation analysis results suggested a relationship between MMP expression and tumor immunity and stemness. Single-cell analysis results revealed diverse MMP expression patterns in different cell clusters. Conclusion: The majority of MMPs showed increased expression across cancers, with potential diagnostic value.
Using 17th Century Medication for Modern Diabetes Management: Doctors’ Perceptions of Self-medication Practices – a Qualitative Study
Authors: Puvvada Rahul Krishna , Tang Clarice Y , Thomas Jency , Kay Mitch , Higgs Peter , Jois Markandeya , Ramesh Madhan , Gupta Sabrina 
Published: February 2022

Abstract
Background: Self-medication practices are common among people living with type 2 diabetes. No studies conducted to understand doctors’ perception towards self-medication practices.Aim: To explore doctors’ perceptions and understanding of the self-medication practices of people living with type 2 diabetes in southwestern India. Methods: Semi-structured face-to-face interviews were conducted with doctors experienced in treating patients with type 2 diabetes in Mysuru, India, between July 2019 and January 2020. The interviews explored factors affecting self-medication practices among people living with type 2 diabetes and doctors’ perception on western and traditional medications in the treatment of type 2 diabetes. All the interviews were audio-recorded and thematic analysis was performed inductively. Results: Twenty doctors were interviewed. Doctors reported greater belief in western medications over traditional medications and expressed concern that their patients favoured traditional medications over western. Factors such as social media, accessibility of healthcare facilities and pill burden influenced adherence to western medications. Lack of knowledge about traditional medications and trust in western medications available under government schemes were observed among doctors. Common medication prescription strategies implemented by doctors to overcome challenges of self-medication practices included educating patients on the detrimental effects of self-medication and insisting patients only take western medications when desired blood glucose levels were not observed.Conclusion: The results suggest that multi-prong approach involving all levels of healthcare is needed to overcome the challenges of self-medication practices. Given the contrasting beliefs between doctors and patients, future studies should explore the impact of integrative medicine on health outcomes diabetes people.
Spatial and temporal variation of diversity seaweed (rhodophyceae, chlorophyceae and Phaeophyceae) in the Marchica lagoon (North-East Morocco)
Authors: AKNAF Asmae , AKODAD Mustapha , Layachi Mostafa , Baghour Mourad , OUDRA Brahim 
Published: February 2022

Abstract
The present work is mainly devoted to determine the distribution spatio-temporel seaweeds inventory of the Marchica lagoon. Several sampling campaigns, carried out at the Marchica lagoon (October 2014, January, April, July 2015, and July 2017), had the following objectives: To study the diversity Seaweeds (macroalgal) in different zones of the Marchica lagoon (north-eastern of Morocco), and stadies the spatio-temporal variation of the Marchica algae. The results obtained provided the identification of about 59 algae species inventories, with the dominance of rhodophyceae Ceramieae C. Agardh is a highly diverse group in terms of number of taxa followed by chlorophyceae and fucophyceae. Chlorophyceae make up the majority of the stand during the spring period, but during the summer period the stand experiences a decrease in chlorophyceae and an increase in rhodophyceae. Rhodophyceae (Gracilaria) are the most abundant seaweeds species at the continental edge, near Oued Tirkâa, at the southeast and south of the lagoon. However, chlorophyceae and rhodophyceae (Gracilaria) are located in large quantities near the new pass. While for the fucophyceae, we noticed the new species of C. barbata, which is not found by González and Conde (1991).
Synthesis, Biological Evaluation and Quantum Chemical Studies of novel 3-Acetylpyridin-2(1H)-one Derivative
Authors: Al-Mosauy Hiba H. Ibraheem , Al-Majedy Yasameen Kadhim , Issa Ali Abdullah 
Published: February 2022

Abstract
2, 4-dihydroxybenzaldehyde reacts for ethyl acetoacetate yielded 3-acetyl-7-hydroxy-2H-chromen-2-one (1), which was then cyclized with ethyl acetoacetate in the presence of ammonium acetate to give compound 3-acetyl-4-(4-(dimethylamino) phenyl) -6-(7-hydroxy-2-oxo-2H-chromen-3-yl)pyridin-2(1H)-one (2). Melting point, TLC, FT-IR spectroscopy, and 1H-NMR were used to characterize the newly synthesized compound. Pyridine (2) is a synthetic compound. Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella sp., and Candida albicans were chosen for their antibacterial and antifungal properties. Compounds 2 demonstrated strong antibacterial activity when compared to the regular drug Ampicillin using the diffusion process. Compound 2 showed high antifungal efficacy as compared to the standard medication fluconazole. The results demonstrated that the tested compounds 1 and 2 have substantially stronger antioxidant activity than the well-known antioxidant ascorbic acid. They had a high ability for scavenging DPPH and hydroxyl radicals. Quantum chemical parameters for the highest occupied molecular orbital energy (EHOMO) and the lowest unoccupied molecular orbital energy (ELUMO) were determined and presented.
Tandem Repeats Ubiquitously Flank and Contribute to Translation Initiation Sites.
Authors: Maddi Ali M.A. , Kavousi Kaveh , Arabfard Masoud , Ohadi Hamid , Ohadi Mina 
Published: February 2022

Abstract
Background: While the evolutionary divergence of cis-regulatory sequences impacts translation initiation sites (TISs), the implication of tandem repeats (TRs) in TIS selection remains elusive for the most part. Hence, here we employed the TIS homology concept to study the co-occurrence patterns of all categories of TRs with TISs.Methods: Human, as reference sequence, and 83 other species were selected, and data was extracted on the entire protein-coding genes (n=1,611,368) and transcripts (n=2,730,515) annotated for those species from Ensembl 102. Two different weighing vectors were employed to assign TIS homology, and the results were assessed in 10-fold validation.Results: On average, every TIS was flanked by 1.19 TRs of various categories within the 120 bp upstream sequence of homologous TISs. We detected statistically significant excess of non-homologous TISs co-occurring with human-specific TRs, vice versa. 2,991 human genes had at least one transcript flanked by a human-specific TR in their upstream flanking region, and nervous system development was the top enriched ontology term across those genes. Text mining of a number of the identified genes such as MYH2, TTN, SLC6A8, CACNA1A, and EIF5AL1 yielded predominant expression and functions in the human brain and skeletal muscle. Conclusion: We conclude that TRs are abundant cis elements in the upstream sequences of TISs across species, and there may be a link between all categories of TRs and TIS selection. The potential biological consequences of this link are discussed in human as the reference sequence in this study.
The Association Between Dietary Glycemic Index and Load With Mental Health
Authors: Amirinejad Ali , Davies Ian G. , Mazidi Mohsen , Nadjarzadeh Azadeh , Darand Mina , Mirzaei Masoud , Khayyatzadeh Sayyed Saeid 
Published: February 2022

Abstract
Background: Psychological disorders including depression, anxiety, and stress comprise a huge public health problem. The aim of this cross-sectional study is to assess the relationship between dietary glycemic index (DGI) and glycemic load (DGL) and mental disorders. Method: Participants (n = 10,000) aged 20-69 were randomly selected from 200 clusters in Yazd from the recruitment phase of Yazd Health Study. The dietary intake of study participants was collected by a reliable and validated food frequency questionnaire (FFQ) consisting of 178 food items. DII and DIL were calculated from the FFQ data using previously published reference values. To assess psychological disorders an Iranian validated short version of a self-reported questionnaire (Depression Anxiety Stress Scales 21 [DASS21]) was used.Results: There were no significant associations between DGI and DGL with odds of depression or anxiety in crude and adjusted models. However, individuals in the highest quartiles of DGL had the lowest odds of stress (OR: 0.69; 95% CI: 0.47–1, P-trend = 0.023). This association remained significant after adjustment for potential confounding variables in model I (OR: 0.45; 95% CI: 0.22–0.9, P-trend = 0.023), model II (OR: 0.46; 95% CI: 0.22–0.96, P-trend = 0.039) and model III (OR: 0.46; 95% CI: 0.22–0.96, P-trend = 0.039). Conclusion: In conclusion, consumption of foods with higher GL was associated with lower odds of stress; however, no significant association was found between GI or GL and risk of depression and anxiety. Performing further studies with longitudinal design is suggested to confirm these results.
Heavy Silicone Oil for Rhegmatogenous Retinal Detachment with Inferior Breaks: Long-term Evaluation
Authors: Horozoglu Fatih , Sener Hidayet , Polat Osman Ahmet , Sever Ozkan , Potoglu Busra , Celik Erkan , Turkoglu Elif Betul , Evereklioglu Cem 
Published: February 2022

Abstract
Purpose: To evaluate macular status with optical coherence tomography (OCT) in eyes that underwent pars plana vitrectomy (PPV) and heavy-silicone oil endotamponade for retinal detachment (RD) with inferior breaks.Methods: This study included 20 eyes of 20 patients with a history of retinal detachment surgery for inferior breaks. Oxane HD was used as an intraocular tamponade for all surgeries. Anatomic reattachment, macular status with OCT imaging and any complications in the long-term were evaluated. Results: Mean follow-up time was 19.5 ± 10.5 months (range, 10-59) after removing heavy-silicone oil or epiretinal membrane (ERM) surgery that was performed in some eyes after heavy-silicone oil removal. Primary reattachment was achieved in 90% of eyes and the success rate was 100% with further interventions. Postoperative complications included heavy-silicone oil emulsification, intraocular pressure elevation and epiretinal membrane formation. Conclusion: Eyes treated with PPV and heavy-silicone oil injection for RD with inferior break(s) have a good ellipsoid zone (EZ) continuity in the long-term. ERM formation and removal do not affect EZ.
miRNA targetome associated with early relapse in high grade serous ovarian cancer
Authors: Karatasli Seyhmus , Kalender Mekselina , Ozcan Gulnihal 
Published: February 2022

Abstract
Background: High-grade serous ovarian cancer (HGSOC) is the most lethal subtype of ovarian cancer due to the high rate of early relapse and resistance to chemotherapy. MicroRNAs (miRNAs) control the post-transcriptional expression of a substantial number of coding genes related to ovarian cancer. Therefore, a great interest in the discovery of miRNA-based therapeutics drives many researchers in the field. To identify relevant targets for miRNA-based therapeutics, in this study we analyzed the miRNA targetome associated with early relapse in HGSOC.Methods: Four Gene Expression Omnibus (GEO) datasets were analyzed by GEO2R to find differentially expressed miRNAs (DEMs) in early relapse patients. The miRDB tool was used to predict the gene targets of the DEMs. Functional annotation and cluster analysis was performed on Database for Visualization and Integrated Discovery and Metascape to identify biological processes enriched in the miRNA targetome. To verify the prognostic role of the key miRNA targets, Kaplan-Meier survival analysis was conducted in a validation dataset curated from The Cancer Genome Atlas and GEO datasets on KM-Plotter. A protein-protein interaction network of the prognostic miRNA targets was constructed on STRING. Network analysis was performed on Cytoscape to find the genes with the highest degree and centrality. The interactors and pathways associated with the key miRNA-target genes were searched on inBio Discover.Results: We identified a wide miRNA targetome with fifteen common miRNA targets associated with early relapse in HGSOC. These miRNA targets were enriched in biological processes associated with “transcription from RNA polymerase II promoter”. Further analysis on the validation set verified the prognostic role of thirteen of these targets in HGSOC. The network analysis revealed CWC27, DCUN1D1, MEF2C, and SPOPL as the central miRNA targets associated with early relapse. The primary interactor hubs of these four genes were involved in processes that regulate the synthesis or cleavage of other gene products, further expanding the scope of impact of the miRNA targetome.Conclusions: We believe that the four miRNA targets we identified in this study may be potential targets of miRNA-based therapeutics to prevent early relapse in HGSOC.
Schistosomes from the Persian Gulf: phylogenetic relationships, host associations and life-cycle elucidation of Ornithobilharzia canaliculata (Rudolphi, 1819) Odhner, 1912
Authors: Khosravi Maral , Thieltges David W. , Shamseddin Jebreil , Georgieva Simona 
Published: February 2022

Abstract
Background: Avian schistosomes comprise a diverse and widespread group of trematodes known for their surprising ability to switch into new hosts and habitats. Their cercariae are the causative agents of the waterborne allergic disease cercarial dermatitis. There are 13 recognised genera of avian schistosomes with majority of the extant species with freshwater-based life-cycles. Despite the considerable research attention on avian schistosomes much less it is known about the diversity, geographical range and host associations of the marine representatives. Here, we provide novel data on the species diversity and host-parasite relationships of the marine schistosomes in respect to their intermediate gastropod host from the Persian Gulf. Methods: A total of 1,745 horn snails of Pirenella cingulata (Gmelin), were examined during a survey from December 2019 to February 2020 from eight distinct locations along the coast of Iran. Partial sequences of the mitochondrial cytochrome c oxidase subunit 1 (cox1) and the nuclear 28S rRNA gene were generated for the schistosome isolates recovered and used for molecular identification and phylogenetic reconstruction. Results: Our molecular analyses inferred from both molecular markers revealed presence of two schistosome species, Ornithobilharzia canaliculata (Rudolphi, 1819) Odhner, 1912 and a putative new species of Austrobilharzia Johnston, 1917. Molecular elucidation of the life-cycle of O. canaliculata was achieved for the first time via matching novel and published sequence data from adult and larval stages. This is the first record of Ornithobilharzia from the Persian Gulf and globally the first record of this genus in a potamidid snail host.Conclusions: The present study provides new host and distribution records for major etiological agents of cercarial dermatitis and contributes important information on host-parasite relationships. Our study further highlights the importance of the molecular systematics in the assessment of schistosome diversity and calls for further surveys in order to reach a better understanding of the schistosome diversity and patterns of relationships among them, host associations, transmission strategies and distribution coverage.