bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjuvant Endocrine Therapy in Premenopausal Breast Cancer: 12-Year Results From SOFT
Authors: Francis Prudence A. , Fleming Gini F. , Láng István , Ciruelos Eva M. , Bonnefoi Hervé R. , Bellet Meritxell , Bernardo Antonio , Climent Miguel A. , Martino Silvana , Bermejo Begoña , Burstein Harold J. , Davidson Nancy E. , Geyer Charles E. , Walley Barbara A. , Ingle James N. , Coleman Robert E. , Müller Bettina , Le Du Fanny , Loibl Sibylle , Winer Eric P. , Ruepp Barbara , Loi Sherene , Colleoni Marco , Coates Alan S. , Gelber Richard D. , Goldhirsch Aron , Regan Meredith M. ,   for the SOFT Investigators and the International Breast Cancer Study Group (a division of ETOP IBCSG Partners Foundation)
Published: December 2022

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported. The Suppression of Ovarian Function Trial (SOFT; ClinicalTrials.gov identifier: NCT00066690 ) randomly assigned premenopausal women with hormone receptor–positive breast cancer to 5 years of adjuvant tamoxifen, tamoxifen plus ovarian function suppression (OFS), or exemestane plus OFS. The primary analysis compared disease-free survival (DFS) between tamoxifen plus OFS versus tamoxifen alone; exemestane plus OFS versus tamoxifen was a secondary objective. After 8 years, SOFT reported a significant reduction in recurrence and improved overall survival (OS) with adjuvant tamoxifen plus OFS versus tamoxifen alone. Here, we report outcomes after median follow-up of 12 years. DFS remained significantly improved with tamoxifen plus OFS versus tamoxifen (hazard ratio, 0.82; 95% CI, 0.69 to 0.98) with a 12-year DFS of 71.9% with tamoxifen, 76.1% with tamoxifen plus OFS, and 79.0% with exemestane plus OFS. OS was improved with tamoxifen plus OFS versus tamoxifen (hazard ratio, 0.78; 95% CI, 0.60 to 1.01) and was 86.8% with tamoxifen, 89.0% with tamoxifen plus OFS, and 89.4% with exemestane plus OFS at 12 years. Among those who received prior chemotherapy for human epidermal growth factor receptor-2–negative tumors, OS was 78.8% with tamoxifen, 81.1% with tamoxifen plus OFS, and 84.4% with exemestane plus OFS. In conclusion, after 12 years, there remains a benefit from including OFS in adjuvant endocrine therapy, with an absolute improvement in OS more apparent with higher baseline risk of recurrence. [Media: see text]
Approach to the Patient With Immune Checkpoint Inhibitor–Associated Endocrine Dysfunction
Authors: Wright Jordan J , Johnson Douglas B 
Published: December 2022

Abstract
Immune checkpoint inhibitors (ICI) are cancer therapies that are approved for use in at least 19 different cancers. They function by stimulating immune cell responses against cancer, and their toxicities comprise a host of autoinflammatory syndromes that may impact any organ system. Endocrine toxicities occur in as high as 25% to 50% of ICI recipients, depending on the treatment regimen used. These toxicities vary in severity from mild, asymptomatic cases of subclinical hypothyroidism to severe, fatal cases of adrenal crisis, thyroid dysfunction, or diabetic ketoacidosis. Thus, timely recognition and treatment is critical. Herein, we present clinical cases of ICI-induced thyroid dysfunction, hypophysitis, and insulin-dependent diabetes mellitus. We use these cases to discuss the screening, diagnosis, and management of ICI-associated endocrine dysfunction.
Artist Development and Collective Therapy in the Repertory: The Case of After Edward
Authors: Kirwan Peter 
Published: December 2022

This article discusses the exploration of the repertory model in Tom Stuart’s 2019 play After Edward, produced at Shakespeare’s Globe. Performed in repertory with a production of Edward II, After Edward dramatizes Diana Taylor’s sense of repertoire; the embodied skills of the actor and the heterochronic site of the Sam Wanamaker Playhouse allow Stuart as actor and writer to reconcile his lived experience as a gay man with his work as an actor. Based on this case study, this article argues that After Edward enacts a praxis of ensemble as artist development.
The Impact of Social Nudges on User-Generated Content for Social Network Platforms
Authors: Zeng Zhiyu , Dai Hengchen , Zhang Dennis J. , Zhang Heng , Zhang Renyu , Xu Zhiwei , Shen Zuo-Jun Max 
Published: December 2022

Content-sharing social network platforms rely heavily on user-generated content to attract users and advertisers, but they have limited authority over content provision. We develop an intervention that leverages social interactions between users to stimulate content production. We study social nudges, whereby users connected with a content provider on a platform encourage that provider to supply more content. We conducted a randomized field experiment (N [Formula: see text]) on a video-sharing social network platform where treatment providers could receive messages from other users encouraging them to produce more, but control providers could not. We find that social nudges not only immediately boosted video supply by 13.21% without changing video quality but also, increased the number of nudges providers sent to others by 15.57%. Such production-boosting and diffusion effects, although declining over time, lasted beyond the day of receiving nudges and were amplified when nudge senders and recipients had stronger ties. We replicate these results in a second experiment. To estimate the overall production boost over the entire network and guide platforms to utilize social nudges, we combine the experimental data with a social network model that captures the diffusion and over-time effects of social nudges. We showcase the importance of considering the network effects when estimating the impact of social nudges and optimizing platform operations regarding social nudges. Our research highlights the value of leveraging co-user influence for platforms and provides guidance for future research to incorporate the diffusion of an intervention into the estimation of its impacts within a social network. This paper was accepted by Victor Martínez-de-Albéniz, operations management. Funding: H. Dai thanks the University of California, Los Angeles (UCLA) [Hellman Fellowship and Faculty Development Award] for funding support. R. Zhang is grateful for financial support from the Hong Kong Research Grants Council [Grant 16505418]. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2022.4622 .
SİVAS İLİ İLBEYLİ TÜRKMEN AVAZLARI ÜZERİNE YAPISAL VE KÜLTÜREL ANALİZ
Authors: DAĞDEVİREN Mustafa 
Published: December 2022

Bayat, Alkırevli (Alka-evli) ve Afşa boyuna bağlı olabilecekleri düşünülen İlbeyli aşiretinin bir kolu olan Sivas İlbeyli Türkmenleri; Sivas Şarkışla arasında, Sivas’ın güneybatısında yer alan 42 köyde ve Sivas merkezde yaşamlarını sürdürmektedirler. Sivas İlbeyli Türkmenlerinin yaşadığı İlbeyli yöresi diye adlandırılan bölge, resmi bir statüde olmayıp kültürel ve demografik yapı ile sınırları belirlenmiş bir coğrafyadır. “Üst başı Kavlak, alt başı Yanalak” şeklindeki söylemlerle sınırı çizilen bu coğrafyayı vatan yapan İlbeyi Türkmenleri bütün kültürel olgularında olduğu gibi müzik kültürlerini de otantizm perspektifinde sürdürmeye devam etmektedirler.
Sivas İlbeyli Türkmenlerinde müziğin ifadelendirilmesinde “avaz” kelimesi kullanılmaktadır. Bu çalışmada, yörede kullanılan “avaz” kavramı açıklanmış, yörede avazı kaynak kişiler tarafından bilinen ezgiler derlenerek notaya alınmıştır. Yöre müzik kültürü içerisinde başat konumda olan ağıtlar ve halayların diğer formlara oranla daha fazla yer aldığı görülmüş olup çalışmanın hacmi makale sınırlarını aşacağından dolayı verilen örneklerde kısıtlamalar yapılmıştır. Çalışma alan araştırmasıyla yöre müziği üzerine yapısal ve kültürel bir analiz yapabilmek adına gerçekleştirilmiştir.
İlbeyli yöresi kolektif belleğinin müziksel bir temsili olan müziklerin kültürel ve biçimsel olarak incelenmesi ve analiz edilmesi, bilimsel kaynak oluşturulması toplumsal ve kültürel görüşlülük ortaya koyulması amacıyla yapılan çalışma Etnomüzikoloji disiplini perspektifinde gerçekleştirilmiştir. Yapılan bu çalışma ile İlbeyli müziği araştırılırken, İlbeyli müzik kültürüne sahip Sivas İlbeyli coğrafyasındaki topluluklar incelenmiş, kültürel yaklaşım perspektifinde müzikal kimlikleri ortaya çıkarılmaya, kavramsallaştırılmaya ve bu müzikler üzerine söylem kurmaya çalışılmıştır.
Yapılan bu araştırmada nitel yöntemler içerisinde bulunan “etnografik araştırma” içerisindeki veri toplama teknikleri (gözlem, görüşme, kayıt alma, analiz etme derleme) kullanılmış, bunun yanı sıra literatür tarama ve tarihsel araştırma teknikleriyle İlbeyli müzik kültürünün derinlemesine araştırılması için ilgili literatür taranmıştır.
Descriptive epidemiology of hospitalized patients with bacterial nosocomial pneumonia who experience 30-day readmission in the US, 2014–2019
Authors: Zilberberg Marya D. , Nathanson Brian H. , Puzniak Laura A. , Zilberberg Noah W. D. , Shorr Andrew F. 
Published: December 2022

Introduction
Nosocomial pneumonia (NP) remains associated with excess morbidity and mortality. The effect of NP on measures such as re-admission at 30 days remains unclear. Moreover, differing types of NP may have varying impacts on re-admissions.

Methods
We conducted a multicenter retrospective cohort study within the Premier Research database, a source containing administrative, pharmacy, and microbiology data. We compared NP patients readmitted with pneumonia (RaP) as the principal diagnosis to those readmitted for other reasons (RaO) with respect to the type of NP (ventilator-associated bacterial pneumonia [VABP], ventilated hospital-acquired bacterial pneumonia [vHABP], and non-ventilated HABP [nvHABP]), and characteristics and outcomes of the index hospitalization.

Results
Among 17,819 patients with NP, 14,123 (79.3%) survived to discharge, of whom 2,151 (15.2%) required an acute readmission within 30 days of index discharge. Of these, 106 (4.9%) were RaP, and the remainder were RaO. At index hospitalization, RaP patients were older (mean age [SD] 67.4 (13.9] vs. 63.0 [15.2] years), more likely medical (44.3% vs. 36.7%), and less chronically ill (median [IQR] Charlson scores (3 [2–5] vs. 4 [2–5]) than persons with RaO. Bacteremia (10.4% vs. 17.5%), need for vasopressors (15.1% vs. 20.0%), dialysis (9.4% vs. 16.5%), and/or sepsis (9.4% vs. 16.5%) or septic shock 14.2% vs. 17.1%) occurred less frequently in the RaP group. With respect to NP type, nvHABP was most common in RaP (47.2%) and VABP in RaO (38.1%).

Conclusions
One in seven survivors of a hospitalization complicated by NP requires an acute rehospitalization within 30 days. However, few of these readmissions had a principal diagnosis of pneumonia, irrespective of NP type. Of the 5% of NP subjects with RaP, the plurality initially suffered from nvHABP.
Depression, anxiety, and burnout among hospital workers during the COVID-19 pandemic: A cross-sectional study
Authors: Pala Andrea Norcini , Chuang Jessica C. , Chien Ai , Krauth David M. , Leitner Stefano A. , Okoye Nnenna M. , Costello Sadie C. , Rodriguez Robert M. , Sheira Lila A. , Solomon Gina , Weiser Sheri D. 
Published: December 2022

Objectives
Healthcare personnel have faced unprecedented mental health challenges during the COVID-19 pandemic. The study objective is to assess differences in depression, anxiety, and burnout among healthcare personnel with various occupational roles and whether financial and job strain were associated with these mental health outcomes.

Methods
We employed an anonymous survey between July and August 2020 at an urban county hospital in California, USA. We assessed depression, anxiety, and burnout using validated scales, and asked questions on financial strain and job strain. We performed logistic and linear regression analyses.

Results
Nurses (aOR 1.93, 95% CIs 1.12, 3.46), social workers (aOR 2.61, 95% CIs 1.35, 5.17), service workers (aOR 2.55, 95% CIs 1.20, 5.48), and administrative workers (aOR 2.93, 95% CIs 1.57, 5.61) were more likely than physicians to screen positive for depression. The odds of screening positive for anxiety were significantly lower for ancillary workers (aOR 0.32, 95% CIs 0.13–0.72) compared with physicians. Ancillary (aB = -1.77, 95% CIs -1.88, -0.47) and laboratory and pharmacy workers (aB -0.70, 95% CI -1.34, -0.06) reported lower levels of burnout compared with physicians. Financial strain partially accounted for differences in mental health outcomes across job categories. Lack of time to complete tasks and lack of supervisory support were associated with higher odds of screening positive for depression. Less job autonomy was associated with higher odds of screening positive for anxiety and higher burnout levels.

Conclusions
We found significant disparities in mental health outcomes across occupational roles. Policies to mitigate the adverse impact of COVID-19 on health workers’ mental health should include non-clinical staff and address financial support and job characteristics for all occupational roles.
Abnormalities of hippocampus and frontal lobes in heart failure patients and animal models with cognitive impairment or depression: A systematic review
Authors: Lu Ziwen , Teng Yu , Wang Lei , Jiang Yangyang , Li Tong , Chen Shiqi , Wang Baofu , Li Yang , Yang Jingjing , Wu Xiaoxiao , Cheng Weiting , Cui Xiangning , Zhao Mingjing 
Published: December 2022

Aims
This systematic review aimed to study the hippocampal and frontal changes of heart failure (HF) patients and HF animal models with cognitive impairment or depression.

Methods
A systematic review of the literature was conducted independently by reviewers using PubMed, Web of Science, Embase, and the Cochrane Library databases.

Results and conclusions
30 studies were included, involving 17 pieces of clinical research on HF patients and 13 studies of HF animal models. In HF patients, the hippocampal injuries were shown in the reduction of volume, CBF, glucose metabolism, and gray matter, which were mainly observed in the right hippocampus. The frontal damages were only in reduced gray matter and have no difference between the right and left sides. The included HF animal model studies were generalized and demonstrated the changes in inflammation and apoptosis, synaptic reduction, and neurotransmitter disorders in the hippocampus and frontal lobes. The results of HF animal model studies complemented the clinical observations by providing potential mechanistic explanations of the changes in the hippocampus and frontal lobes.
Pre-service factors associated with sexual misconduct among male U.S. Marines
Authors: LeardMann Cynthia A. , Haile Yohannes G. , McAnany Jennifer , Stander Valerie A. , Williams Diane , Millegan Jeffrey , Carlton Keyia N. ,   for the Recruit Assessment Program
Published: December 2022

Purpose
Sexual assault is a prevalent and persistent problem in the military, yet few studies have examined predictors of sexual offenses. The study aim was to determine pre-service factors associated with sexual offense conviction among U.S. Marines.

Methods
This retrospective cohort study analyzed data from male active duty U.S. Marines (2003–2018). Pre-service factors were assessed using survey data from the Recruit Assessment Program, obtained prior to recruit training at the Marine Corps Recruit Depot, San Diego, California. These survey data were linked with sexual offense conviction data obtained from the Naval Criminal Investigative Service Consolidated Law Enforcement Operations Center.

Results
Of the 146,307 participants, the majority were 18–19 years old (66.7%) and non-Hispanic, White (62.1%) with a high school education or less (76.8%); 107 received convictions for a sexual offense. In unadjusted analyses, race and ethnicity, parental education, type of primary caregiver, parental death, family economic status, childhood emotional trauma, childhood physical abuse, childhood sexual abuse, and unprotected sex were associated with a sexual offense conviction. In the final multivariable model, race and ethnicity (American Indian/Alaskan Native, odds ratio [OR]: 5.28, 95% confidence interval [CI]: 1.86–14.98; Hispanic, OR: 1.83, 95% CI: 1.06–3.18; multiracial/other, OR: 3.28, 95% CI: 1.56–6.89), education (≤ high school, OR: 2.65; 95% CI: 1.21–5.80), parental death (OR: 2.27; 95% CI: 1.16–4.45), unprotected sex (OR: 1.78; 95% CI: 1.03–3.05), and school suspension/expulsion (OR: 1.64; 95% CI: 1.02–2.65) were significant predictors of a subsequent sexual offense conviction.

Conclusions
Results underscore the importance of understanding factors associated with sexual offense and highlight the large discrepancy between self-reported estimates of sexual assault and sexual offense convictions. Findings may inform the development of effective strategies to reduce sexual misconduct, such as technology-facilitated programs that provide private, targeted education; supportive assistance; and prevention materials to individuals who may have elevated sexual misconduct risk.
Impact of increased kidney function on clinical and biological outcomes in real-world patients treated with Direct Oral Anticoagulants
Authors: Corrochano Mariana , Acosta-Isaac René , Plaza Melania , Muñoz Rodrigo , Mojal Sergi , Moret Carla , Souto Joan Carles 
Published: December 2022

Background and purpose
Renal excretion of direct oral anticoagulants (DOACs) varies depending on the drug. Hypothetically, an increased glomerular filtration rate (GFR) may lead to suboptimal dosing and a higher thromboembolic events incidence. However, real-world patient data do not support the theoretical risk. The aim is to analyse DOAC outcomes in patients with normal and high (≥90 mL/min) GFR, focusing on biological parameters and thrombotic/haemorrhagic events.

Methods
Observational prospective single-centre study and registry of patients on DOACs. Follow-up was 1,343 patient-years. A bivariate analysis was performed of baseline variables according to GFR (<90 mL/min vs ≥90 mL/min). Anti-Xa activity before and after drug intake (HemosIL, Liquid Anti-Xa, Werfen) was measured for edoxaban, apixaban, and rivaroxaban; diluted thrombin time for dabigatran (HEMOCLOT); and additionally, plasma concentrations in edoxaban (HemosIl, Liquid Anti-Xa suitably calibrated).

Results
1,135 patients anticoagulated with DOACs were included and 152 patients with GFR ≥90 mL/min. Of 18 serious thrombotic complications during follow-up, 17 occurred in patients with GFR <90 mL/min, and 1 in a patient with GFR ≥90 mL/min. A higher incidence of complications was observed in patients with normal GFR, but the difference was not statistically significant (p>0.05). No statistically significant differences with clinical relevance were observed between the normal or supranormal groups in anti-Xa activity or in edoxaban plasma concentrations.

Conclusions
There was no increased incidence of thrombotic/haemorrhagic complications in our patients treated with DOACs, including 66% treated with edoxaban, and patients with GFR ≥90 mL/min. Likewise, drug anti-Xa activity and edoxaban plasma concentration did not seem to be influenced by GFR.
Factors associated with non-response to naldemedine for opioid-induced constipation in cancer patients: A subgroup analysis
Authors: Kanbayashi Yuko , Shimizu Mayumi , Ishizuka Yuichi , Sawa Shohei , Yabe Katsushige , Uchida Mayako 
Published: December 2022

Background
Opioid-induced constipation (OIC) is one of the most common adverse events of opioid therapy and can severely reduce quality of life (QOL). Naldemedine is the orally available peripheral-acting μ-opioid receptor antagonist approved for OIC treatment. However in daily clinical practice, some cancer patients show insufficient control of OIC even while receiving naldemedine.

Objective
To identify factors associated with non-response to naldemedine in cancer patients.

Methods
This study retrospectively analyzed 127 cancer patients prescribed naldemedine at Seirei Hamamatsu General Hospital in Japan between November 2016 and June 2021. For the regression analysis of factors associated with OIC, variables were extracted manually from electronic medical records. Naldemedine had been prescribed by the attending physician after the presence of OIC had been defined with reference to Rome IV diagnostic criteria. Naldemedine was evaluated as “effective” in cases where the number of defecations increased at least once in the first 3 days after starting naldemedine. Multivariate logistic regression analysis was performed to identify factors associated with non-response to naldemedine. The data used were from the group of patients who received naldemedine in our previous study.

Results
Factors significantly associated with non-response to naldemedine included chemotherapy with taxanes within 1 month of evaluation of naldemedine effect (odds ratio [OR] = 0.063; 95% confidence interval [CI] = 0.007–0.568), and addition of or switching to naldemedine due to insufficient efficacy of prior laxatives (OR = 0.352, 95% CI = 0.129–0.966).

Conclusion
The identification of factors associated with non-response to naldemedine prescribed for OIC may help improve QOL among cancer patients.
Collateral positives of COVID-19 for culturally and linguistically diverse communities in Western Sydney, Australia
Authors: Cornell Samuel , Ayre Julie , Mac Olivia , Kapoor Raveena , Pickles Kristen , Batcup Carys , Dolan Hankiz , Bonner Carissa , Cvejic Erin , Mouwad Dana , Zacharia Dipti , Tularic Una , Santalucia Yvonne , Chen Ting Ting , Basic Gordana , McCaffery Kirsten , Muscat Danielle 
Published: December 2022

BackgroundTo investigate whether culturally and linguistically diverse (CALD) communities in Western Sydney have experienced any positive effects during the COVID-19 pandemic, and if so, what these were.MethodsA cross–sectional survey with ten language groups was conducted from 21stMarch to 9thJuly 2021 in Sydney, Australia. Participants were recruited through bilingual multicultural health staff and health care interpreter service staff and answered a question, ‘In your life, have you experienced any positive effects from the COVID-19 pandemic?’ Differences were explored by demographic variables. Free–text responses were thematically coded using the Content Analysis method.Results707 people completed the survey, aged 18 to >70, 49% males and 51% females. Only 161 (23%) of those surveyed reported any positive impacts. There were significant differences in the proportion of those who reported positives based on age (p = 0.004), gender (p = 0.013), language (p = 0.003), health literacy (p = 0.014), English language proficiency (p = 0.003), education (p = <0.001) and whether participants had children less than 18 years at home (p = 0.001). Content Analysis of open-ended responses showed that, of those that did report positives, the top themes were ‘Family time’ (44%), ‘Improved self-care’ (31%) and, ‘Greater connection with others’ (17%).DiscussionFew surveyed participants reported finding any positives stemming from the COVID–19 pandemic. This finding is in stark contrast to related research in Australia with participants whose native language is English in which many more people experienced positives. The needs of people from CALD backgrounds must inform future responses to community crises to facilitate an equitable effect of any collateral positives that may arise.