bluuebunny/crossref_metadata_2025_split huggingface dataset:
Op weg naar een nieuw regime voor uitbesteding van KYC-verplichtingen op grond van de Wwft
Authors: Strijder J.J. , Lopik S.J. 
Published: February 2022

Op weg naar een nieuw regime voor uitbesteding van KYC-verplichtingen op grond van de Wwft
De laatste jaren is een grote interesse ontstaan voor verplichtingen die voortkomen uit de Wet ter voorkoming van witwassen en financieren van terrorisme (Wwft). Dit komt onder andere door de toenemende eisen die de wetgever op grond van de Wwft stelt aan de poortwachtersfunctie van allerlei organisaties, zoals banken en accountants. Daarnaast is de Wwft een speerpunt van diverse autoriteiten geworden, en is het Openbaar Ministerie (OM) tot aanzienlijke schikkingen voor Wwft-overtredingen gekomen. Veel instellingen hebben in de afgelopen jaren dan ook fors geïnvesteerd om aan de toenemende eisen op het gebied van know your customer (KYC) te voldoen. Dit roept de vraag op of KYC-werkzaamheden kunnen worden uitbesteed aan gespecialiseerde dienstverleners die dit werk mogelijk beter en kostenefficiënter kunnen uitvoeren. Mocht een instelling besluiten om tot uitbesteding over te gaan, dan moet dit zorgvuldig gebeuren. De Wwft kent hiertoe regels en verschillende autoriteiten bieden enkele handvatten. In de praktijk laat de handzaamheid hiervan echter niet zelden te wensen over. In deze bijdrage gaan wij in op het uitbestedingsregime onder de Wwft en kijken wij naar de veranderingen die op dit gebied op komst lijken te zijn.
Palliative care applied to the elderly at home / Cuidados paliativos aplicados em idosos no domicílio
Authors: Santos Adrielle Alves , Lopes Arianna Oliveira Santana , Gomes Nildete Pereira , Oliveira Lélia Mendes Sobrinho de 
Published: February 2022

Objetivo: analisar evidências científicas sobre a utilização de cuidados paliativos aplicados em idosos no domicílio. Métodos: trata-se de uma revisão sistemática de literatura, realizada em janeiro de 2020, utilizando os descritores: “cuidados paliativos/Paliative care” AND “saúde do idoso/heal thof the elderly” AND “assistência domiciliar/home care”. Resultados: foram selecionados sete artigos, que emergiram as categorias: Assistência domiciliar adaptada as necessidades dos pacientes de acordo com seus recursos disponíveis; Ampliação dos resultados através do empoderamento e autonomia na participação do cuidado familiar no domicílio; Os cuidados paliativos contribuem para a melhoria dos fatores psicológicos e emocionais, enfrentamento positivo e aceitação do tratamento. Conclusão: a utilização dos cuidados paliativos para o atendimento domiciliar ao idoso, que a literatura traz uma aplicabilidade geral sem estudos que tratem de forma específica a situação do idoso. Demonstra também um aumento deliberado da necessidade de assistência permanente a estas pessoas com doenças incuráveis, necessitando de apoio holístico.
Opposing effects of NMDA receptor antagonists on early life stress‐induced aggression in mice
Authors: Nordman Jacob C. , Bartsch Caitlyn J. , Li Zheng 
Published: February 2022

AbstractRates of childhood trauma are high amongst violent offenders who frequently recidivate. Few clinical options are available to treat excessive and recurring violent aggression associated with childhood trauma. Those that do exist are largely ineffective and often replete with side effects. One promising pharmacological target is the glutamate binding N‐methyl‐
d‐aspartate receptor (NMDAR). Clinically available NMDAR antagonists have proven successful in mitigating violent and aggressive behavior associated with a host of psychiatric diseases and have both immediate and long‐term effects on nervous system function and behavior. This study examined the impact of three NMDAR antagonists on long‐lasting aggression brought on by early‐life stress: MK‐801, memantine, and ketamine. We find that social isolation early in adolescence followed by acute traumatic stress in the form of noncontingent foot shock (FS) late in adolescence works in tandem to promote long‐lasting excessive aggression in mice when measured 1 week later. Systemic injections of MK‐801 and memantine 30 min before FS suppressed the long‐lasting attack behavior induced by our early life stress induction protocol. Systemic injections of ketamine, on the other hand, significantly enhanced the long‐lasting attack behavior when injected before FS. These findings indicate that MK‐801, memantine, and ketamine have distinct and opposing effects on early life stress‐induced aggression, suggesting these drugs may be mechanistically distinct. This study identifies memantine as a promising pharmacological treatment for aggressive behavior associated with early life stress and demonstrates the need for greater care when using glutamate receptor antagonists to treat aggression.
Antibody–Pattern Recognition Receptor Agonist Conjugates: A Promising Therapeutic Strategy for Cancer
Authors: Xu Jian , Li Xiang , Du Yue 
Published: February 2022

AbstractAntibody–drug conjugates (ADCs) are composed of monoclonal antibodies linked to cytotoxic payload drugs, each of which can be diversely designed in accordance with pharmacological and clinical requirements. The use of ADCs is effective for the treatment of different diseases, including cancers, and is gaining widespread attention. To date, 12 ADCs have been approved by the U.S. Food and Drug Administration for treating cancer and improving the quality of life of patients. To expand the application of ADCs and improve their treatment efficiency, various formats have recently been manufactured, including pattern recognition receptor (PRR) agonist‐based ADCs. The antibody has a unique structure that enables the specific delivery of PRR agonists to the tumor area, and this improves the therapeutic efficacy while minimizing systemic toxicity. This review briefly discusses the current landscape and future perspectives of antibody–PRR agonist conjugates for cancer therapy.
Single‐Ion Magnetostriction in Gd2O3–CeO2 Solid Solutions
Authors: Zhang Xiao‐Dong , Varenik Maxim , Zvezdin Konstantin , Ehre David , Wachtel Ellen , Zhu Zengwei , Leitus Gregory , Popov Alexander , Zvezdin Anatoly , Peng Tao , Lubomirsky Igor , Guo Xin 
Published: February 2022

AbstractCeria (CeO2) and its solid solutions with Gd2O3 are technologically important and environmentally friendly materials with numerous interesting properties and important applications. Nevertheless, the magnetic properties of ceria are even today not fully understood, and magnetoelastic coupling in pure or doped ceria remains essentially unexplored. This has been so, in part, due to the difficulty of measuring very small magnetostrictive strains in weakly paramagnetic materials. During the last decade, however, technical advances have enabled sensitive and accurate measurements of sample deformation in high magnetic fields. Here, forced magnetostriction (MS) in Gd2O3‐CeO2 solid solution ceramics (Ce1−xGdxO2−x/2, 0 ≤ x ≤ 1) at room temperature is characterized. In a pulsed magnetic field μ0H ≤ 60 Tesla, longitudinal MS strain is observed to depend on the square of the field amplitude and to increase linearly with Gd3+ concentration but is not sensitive to the lattice symmetry of the ceramics. The theory attributes the origin of the observed strain to the single‐ion MS response of Gd3+ to the crystal field via mixing of ground and excited electronic states and covalent hybridization with oxygen ligands. Contributions of charge‐compensating oxygen vacancies and/or Van Vleck paramagnetism to the observed magnetoelastic coupling are determined to be negligible.
Non‐Radiative Recombination Energy Losses in Non‐Fullerene Organic Solar Cells
Authors: He Dan , Zhao Fuwen , Wang Chunru , Lin Yuze 
Published: February 2022

AbstractImpressive short‐circuit current density and fill factor have been achieved simultaneously in single‐junction organic solar cells (OSCs) with the emergence of high‐performance non‐fullerene acceptors. However, the power conversion efficiencies (PCEs) of OSCs still lag behind those of inorganic and perovskite solar cells, mainly due to the modest open‐circuit voltage (VOC) imposed by relatively large energy loss (Eloss). Generally, Eloss in solar cells can be divided into three parts. Among them, ΔE1 is inevitable for all photovoltaic cells and depends on the optical bandgap of solar cells, while radiative recombination energy loss, ΔE2, in OSCs can approach the negligible value via finely matching donor with acceptor material in the blend. The relatively large non‐radiative recombination energy loss, ΔE3, becomes the main barrier to further reduce Eloss and thus enhance PCE in non‐fullerene acceptor‐based OSCs. In this review, the recent studies and achievements about ΔE3 in non‐fullerene acceptor‐based OSCs have been summarized from the aspects of material design, morphology manipulation, ternary strategy, mechanism, and theoretical study. It is hoped that this review helps to get a deep understanding and boost the advance of ΔE3 study in OSCs.
Insoluble Naphthoquinone‐Derived Molecular Cathode for High‐Performance Lithium Organic Battery
Authors: Zhao Bowen , Si Yubing , Guo Wei , Fu Yongzhu 
Published: February 2022

AbstractOrganic electrode materials have attracted significant attention for rechargeable lithium organic batteries owing to the anticipated electrochemical property and environmentally friendly features. Benzoquinone and naphthoquinone as the simplest quinone substances have been considered as promising cathode materials because of their high theoretical specific capacities and discharge voltages. However, they are soluble in most organic liquid electrolytes, which results in poor electrochemical performance. Herein, a novel molecular cathode material based on naphthoquinone, i.e., 2,2'‐(1,4‐phenylenedithio) bis(1,4‐naphthoquinone) (1,4‐PNQ), is designed and synthesized. It shows greatly decreased solubility as a result of strong intermolecular interactions. In a lithium half cell, it exhibits high carbonyl utilization of close to 100% with a high initial capacity of 231 mAh g‐1. Meanwhile, 1,4‐PNQ presents improved cyclability, retaining a high capacity of 185 mAh g‐1 after 120 cycles. Remarkably, it retains 93.5% of the initial capacity after 500 cycles at 5 C rate. This work provides a novel molecular design strategy to develop naphthoquinone‐derived cathode materials for high performance lithium organic batteries.
On the Origin of Seebeck Coefficient Inversion in Highly Doped Conducting Polymers
Authors: Xu Kai , Ruoko Tero‐Petri , Shokrani Morteza , Scheunemann Dorothea , Abdalla Hassan , Sun Hengda , Yang Chi‐Yuan , Puttisong Yuttapoom , Kolhe Nagesh B. , Figueroa José Silvestre Mendoza , Pedersen Jonas O. , Ederth Thomas , Chen Weimin M. , Berggren Magnus , Jenekhe Samson A. , Fazzi Daniele , Kemerink Martijn , Fabiano Simone 
Published: February 2022

AbstractA common way of determining the majority charge carriers of pristine and doped semiconducting polymers is to measure the sign of the Seebeck coefficient. However, a polarity change of the Seebeck coefficient has recently been observed to occur in highly doped polymers. Here, it is shown that the Seebeck coefficient inversion is the result of the density of states filling and opening of a hard Coulomb gap around the Fermi energy at high doping levels. Electrochemical n‐doping is used to induce high carrier density (>1 charge/monomer) in the model system poly(benzimidazobenzophenanthroline) (BBL). By combining conductivity and Seebeck coefficient measurements with in situ electron paramagnetic resonance, UV–vis–NIR, Raman spectroelectrochemistry, density functional theory calculations, and kinetic Monte Carlo simulations, the formation of multiply charged species and the opening of a hard Coulomb gap in the density of states, which is responsible for the Seebeck coefficient inversion and drop in electrical conductivity, are uncovered. The findings provide a simple picture that clarifies the roles of energetic disorder and Coulomb interactions in highly doped polymers and have implications for the molecular design of next‐generation conjugated polymers.
Immunomodulatory Microgels Support Proregenerative Macrophage Activation and Attenuate Fibroblast Collagen Synthesis
Authors: Mohammadi Sepideh , Ravanbakhsh Hossein , Taheri Sareh , Bao Guangyu , Mongeau Luc 
Published: February 2022

AbstractScars composed of fibrous connective tissues are natural consequences of injury upon incisional wound healing in soft tissues. Hydrogels that feature a sustained presentation of immunomodulatory cytokines are known to modulate wound healing. However, existing immunomodulatory hydrogels lack interconnected micropores to promote cell ingrowth. Other limitations include invasive delivery procedures and harsh synthesis conditions that are incompatible with drug molecules. Here, hybrid nanocomposite microgels containing interleukin‐10 (IL‐10) are reported to modulate tissue macrophage phenotype during wound healing. The intercalation of laponite nanoparticles in the polymer network yields microgels with tissue‐mimetic elasticity (Young's modulus in the range of 2–6 kPa) and allows the sustained release of IL‐10 to promote the differentiation of macrophages toward proregenerative phenotypes. The porous interstitial spaces between microgels promote fibroblast proliferation and fast trafficking (an average speed of ≈14.4 µm h−1). The incorporation of hyaluronic acid further enhances macrophage infiltration. The coculture of macrophages and fibroblasts treated with transforming growth factor‐beta 1 resulted in a twofold reduction in collagen‐I production for microgels releasing IL‐10 compared to the IL‐10 free group. The new microgels show potential toward regenerative healing by harnessing the antifibrotic behavior of host macrophages.
A Self‐Powered Dual‐Type Signal Vector Sensor for Smart Robotics and Automatic Vehicles
Authors: Li Shaoxin , Zhao Zhihao , Liu Di , An Jie , Gao Yikui , Zhou Linglin , Li Yanhong , Cui Shengnan , Wang Jie , Wang Zhong Lin 
Published: February 2022

AbstractAutomatic control systems are the most efficient technology for reducing labor cost while improving work efficiency. Vector motion monitoring is indispensable for the normal operation of automatic control systems. Here, a self‐powered dual‐type signal triboelectric nanogenerator (DS‐TENG) is designed through integrating an alternating‐current TENG and a direct‐current TENG, which can monitor vector movement in real time based on pulse signal counts. As a result, the DS‐TENG avoids the shortcoming of traditional self‐powered sensors based on signal amplitude that is sensitive to the working environment, achieves a high sensing precision, and maintains stability after reciprocating motion of 500 000 cycles. Moreover, it realizes effective movement direction recognition by self‐powered switching of signal type in reverse movement. This dual‐type signal TENG exhibits high precision and automatic direction recognition in vector motion monitor and trajectory tracker, paving the way for the application of the self‐powered TENG sensor in automatic control systems in the future.
High‐Polarizability Organic Ferroelectric Materials Doping for Enhancing the Built‐In Electric Field of Perovskite Solar Cells Realizing Efficiency over 24%
Authors: Chen Weijie , Liu Shuo , Li Qingqing , Cheng Qinrong , He Baosheng , Hu Zhijun , Shen Yunxiu , Chen Haiyang , Xu Guiying , Ou XueMei , Yang Heyi , Xi Jiachen , Li Yaowen , Li Yongfang 
Published: February 2022

AbstractThe built‐in electric field (BEF) intensity of silicon heterojunction solar cells can be easily enhanced by selective doping to obtain high power conversion efficiencies (PCEs), while it is challenging for perovskite solar cells (pero‐SCs) because of the difficulty in doping perovskites in a controllable way. Herein, an effective method is reported to enhance the BEF of FA0.92MA0.08PbI3 perovskite by doping an organic ferroelectric material, poly(vinylidene fluoride):dabcoHReO4 (PVDF:DH) with high polarizability, that can be driven even by the BEF of the device itself. The polarization of PVDF:DH produces an additional electric field, which is maintained permanently, in a direction consistent with that of the BEF of the pero‐SC. The BEF superposition can more sufficiently drive the charge‐carrier transport and extraction, thus suppressing the nonradiative recombination occurring in the pero‐SCs. Moreover, the PVDF:DH dopant benefits the formation of a mesoporous PbI2 film, via a typical two‐step processing method, thereby promoting perovskite growth with high crystallinity and a few defects. The resulting pero‐SC shows a promising PCE of 24.23% for a 0.062 cm2 device (certified PCE of 23.45%), and a remarkable PCE of 22.69% for a 1 cm2 device, along with significantly improved moisture resistances and operational stabilities.
Non‐Fullerene Acceptor Organic Photodetector for Skin‐Conformable Photoplethysmography Applications
Authors: Simões João , Dong Tao , Yang Zhaochu 
Published: February 2022

AbstractCommercial photoplethysmography (PPG) sensors and other biomedical devices that require near‐infrared (NIR) light detection are limited by rigid photodetector architectures that cannot interface comfortably with skin. Flexible organic photodetectors could potentially solve this problem; however, organic photodetectors suffer from low NIR sensitivity, largely due to the early absorption cutoffs originating from the use of fullerene acceptors. This work details a new flexible organic photodiode (OPD) based on narrow bandgap non‐fullerene‐acceptor (NFA) bulk heterojunction (BHJ) incorporating a PTB7‐Th and COTIC‐4F blend. The photodetector developed for this study reaches an external an external quantum efficiency (EQE) to 60% in the 600–1000 nm range and responsivity (R) as high as ≈0.42 A W–1. Through the integration of a PEDOT:PSS and PDINO interfacial layers, undesired carrier injection is suppressed, and a detectivity (D*) in the order of ≈1013 Jones is achieved. In addition, oxygen saturation and heart rate are successfully measured by integrating the developed photodiode in a PPG sensor.
ZnO Nanowire‐Based Early Detection of SARS‐CoV‐2 Antibody Responses in Asymptomatic Patients with COVID‐19
Authors: Kim Jung , Lee Sung Kyun , Lee Jong‐Hwan , Kim Hye‐Yeon , Kim Nam Hoon , Lee Chang Hoon , Lee Chang‐Seop , Kim Hong Gi 
Published: February 2022

AbstractA serological immunoassay based on enzyme‐linked immunosorbent assay (ELISA) is a crucial tool for screening and identification of human SARS‐CoV‐2 seroconversion. Various immunoassays are developed to detect the spike 1 (S1) and nucleocapsid (NP) proteins of SARS‐CoV‐2; however, these serological tests have low sensitivity. Here, a novel microplate (MP) is developed on which a ZnO nanowire (NW) is fabricated by a modified hydrothermal synthesis method. This plate is coated with SARS‐CoV‐2 NP and used as a fluorescent immunoassay (FIA) to detect antibodies specific for SARS‐CoV‐2 NP. Compared with the bare MP, the ZnO‐NW MP binds high levels (up to 5 µg mL−1) of SARS‐CoV‐2 NP tagged to histidine without any surface treatment. A novel serological assay based on the ZnO‐NW MP is more sensitive than a commercial immunoassay, enabling early detection (within <5 days of a reverse transcription polymerase chain reaction‐confirmed COVID‐19 infection) of anti‐SARS‐CoV‐2 NP IgG antibodies in asymptomatic patients with COVID‐19. This is the first assay to detect early antibody responses to SARS‐CoV‐2 in asymptomatic patients. Therefore, this serological assay will facilitate accurate diagnosis of COVID‐19, as well as estimation of COVID‐19 prevalence and incidence.
Effects of PDMS Base/Agent Ratios and Texture Sizes on the Electrical Performance of Triboelectric Nanogenerators
Authors: Sun Zhen , Yang Weixu , Chen Ping , Zhang Yuyan , Wang Xiaoli , Hu Yanqiang 
Published: February 2022

AbstractTriboelectric nanogenerator (TENG) is a micro/nano electromechanical power system that converts mechanical energy into electricity based on contact electrification and electrostatic induction. At present, research on improving TENG performance mainly focus on material optimization and texture fabrication. This paper proposes a simple material optimization method based on regulating the ratio of elastomer base to curing agent (base/agent ratio) of Polydimethylsiloxane (PDMS) to improve the performance of TENG with rectangular groove textures, and the influence of texture sizes on TENG output is explored. By analyzing the contact behavior, dielectric, and mechanical property, the influence mechanism of PDMS base/agent ratios and texture sizes on TENG performance is revealed. Results show that PDMS base/agent ratios affect TENG output mainly through material dielectric properties, while texture sizes mainly by contact behaviors. As the base/agent ratio decreases, although the real contact area and displacement of PDMS exhibit slight reductions, the relative permittivity of PDMS increases, and thus the surface charge density and performance of TENG increases. As the boss width increases or the groove width decreases, the displacement of PDMS declines, which would lead to the slight drop of the surface charge density, but the real contact area increases, which still results in improved TENG output.
Phosphine(III)‐Triggered One‐Pot Domino Sequences towards 5,6‐Dihydropyridine‐2‐(1H)‐One and Pyridine‐2(1H)‐One Scaffolds
Authors: Makra Zsófia , Madácsi Ramóna , Martinek Tamás A. , Bényei Attila , Puskás László G. , Gyuris Márió , Kanizsai Iván 
Published: February 2022

AbstractAn elegant P(nBu)3‐triggered synthetic approach has been developed towards multisubstituted 5,6‐dihydropyridin‐2(1H)‐one and pyridin‐2(1H)‐one derivatives exploiting a domino process involving retro‐Claisen/intra‐MBH/Wittig/vinylogous aldol transformations as well as retro‐Claisen/intra‐MBH/ylide hydrolysis/oxidation sequences. This transformation demonstrates chemo‐ and regioselectivity as well as accessible high diversity enchancement in 17–90% isolated yield.magnified image
Multi‐Functional Small Molecules with Temporal Charge‐Switchability Tackle Infection and Inflammation
Authors: Barman Swagatam , Dhanda Geetika , Naik Poonam , Mukherjee Riya , Jolly Logia , Joseph Joveeta , Haldar Jayanta 
Published: February 2022

AbstractThe alarming situation in public healthcare caused by ever‐increasing catastrophe of antimicrobial resistance, recurrent infections, and associated inflammation has accelerated the hunt for novel therapeutics which can address these diverse problems concomitantly. This article introduces a new class of multi‐functional amino acid conjugated small antibacterial molecules (ASAMs) which tackle complicated infections and associated inflammation. These molecules exhibit broad‐spectrum bactericidal activity against multi‐drug‐resistant bacteria. The phenylalanine‐bearing lead molecule (ASAM‐10) tackles bacterial dormant subpopulations, impenetrable biofilms, and intracellular pathogens simultaneously. Importantly, this molecule addresses the problem of toxicity associated with cationic lipopeptides like colistin through the temporal charge switching (cationic to zwitterionic) owing to the degradation of labile ester linkages. However, this does not affect its desired antibacterial action window. The substantial reduction in the overexpression of pro‐inflammatory cytokines (IL‐6, IL‐8, TNF‐α, and IL‐1β) upon treatment of infected macrophages with ASAM‐10 validates its anti‐inflammatory efficacy. Furthermore, bacteria exhibit diminished susceptibility toward resistance development against ASAM‐10 owing to its membrane‐active nature. ASAM‐10 displays significant reduction in bacterial burden (2 Log CFU/g) when administered intraperitoneally in mice for MRSA thigh infection. Overall, this new class of multi‐functional molecules is safe for anticipated advanced therapeutic applications to combat complex bacterial infections and inflammation.