bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contract’s Influence on Feminism and Vice Versa
Authors: Ertman Martha M. 
Published: January 2022

Abstract
Feminist legal theory has both embraced and rejected contract. While contract-based conceptual and doctrinal tools have improved women’s economic and social status, feminists also critique contract-based reforms for colluding with hierarchies of gender, race and class. This chapter charts influential work on both sides of the contract debate and identifies a third approach that sees contract as a mechanism for law to move away from a hierarchal regime by stopping at a contractual way station en route to a more equal system of public ordering. It concludes by identifying ways that feminist legal theorists have injected feminist insights into traditional contract law via doctrines such as good faith in employment contracts, debtor rights in lending relationships, and defenses including unconscionability and duress.
Indigenous Peoples’ Earnings, Inequality, and Well-Being
Authors: Akee Randall 
Published: January 2022

Abstract
This chapter describes earnings inequality and poverty measures for four groups of Indigenous peoples in the United States over the past 30 years using available data. The analysis provides a useful comparison to racial and ethnic minorities in the United States. Additionally, the chapter explores ways in which the existing measures of monetary income and earnings may miss significant sources of resource exchange, transfer, and provision in these communities. Accounting for these additional activities may indicate that these communities are more resilient than official measures would suggest. This chapter also argues that certain environmental and natural resources provide uncounted and unmeasured value; however, the benefit and value that they provide to communities and peoples are not allocated via price mechanisms and are thus not easily counted or measured. A potential solution is the inclusion of expanded questions and surveys that include questions that measure non-market-based flows of income and services for Indigenous peoples.
The three-year shear catalog of the Subaru Hyper Suprime-Cam SSP Survey
Authors: Li Xiangchong , Miyatake Hironao , Luo Wentao , More Surhud , Oguri Masamune , Hamana Takashi , Mandelbaum Rachel , Shirasaki Masato , Takada Masahiro , Armstrong Robert , Kannawadi Arun , Takita Satoshi , Miyazaki Satoshi , Nishizawa Atsushi J , Plazas Malagon Andres A , Strauss Michael A , Tanaka Masayuki , Yoshida Naoki 
Published: January 2022

Abstract
We present the galaxy shear catalog that will be used for the three-year cosmological weak gravitational lensing analyses using data from the Wide layer of the Hyper Suprime-Cam (HSC) Subaru Strategic Program (SSP) Survey. The galaxy shapes are measured from the i-band imaging data acquired from 2014 to 2019 and calibrated with image simulations that resemble the observing conditions of the survey based on training galaxy images from the Hubble Space Telescope in the COSMOS region. The catalog covers an area of 433.48 deg2 of the northern sky, split into six fields. The mean i-band seeing is ${0{^{\prime \prime}_{.}}59}$. With conservative galaxy selection criteria (e.g., i-band magnitude brighter than 24.5), the observed raw galaxy number density is 22.9 arcmin−2, and the effective galaxy number density is 19.9 arcmin−2. The calibration removes the galaxy property-dependent shear estimation bias to the level |δm| &lt; 9 × 10−3. The bias residual δm shows no dependence on redshift in the range 0 &lt; z ≤ 3. We define the requirements for cosmological weak-lensing science for this shear catalog, and quantify potential systematics in the catalog using a series of internal null tests for systematics related to point-spread function modelling and shear estimation. A variety of the null tests are statistically consistent with zero or within requirements, but (i) there is evidence for PSF model shape residual correlations; and (ii) star–galaxy shape correlations reveal additive systematics. Both effects become significant on &gt;1° scales and will require mitigation during the inference of cosmological parameters using cosmic shear measurements.
The rice phosphate transporter OsPHT1;7 plays a dual role in phosphorus redistribution and anther development
Authors: Dai Changrong , Dai Xiaoli , Qu Hongye , Men Qin , Liu Jingyang , Yu Ling , Gu Mian , Xu Guohua 
Published: January 2022

Abstract
Inorganic phosphate (Pi) is the predominant form of phosphorus (P) readily accessible to plants, and Pi Transporter 1 (PHT1) genes are the major contributors to root Pi uptake. However, the mechanisms underlying the transport and recycling of Pi within plants, which are vital for optimizing P use efficiency, remain elusive. Here, we characterized a functionally unknown rice (Oryza sativa) PHT1 member barely expressed in roots, OsPHT1;7. Yeast complementation and Xenopus laevis oocyte assay demonstrated that OsPHT1;7 could mediate Pi transport. Reverse-transcription quantitative polymerase chain reaction and histochemical analyses showed that OsPHT1;7 was preferentially expressed in source leaves and nodes. A further fine-localization analysis by immunostaining showed that OsPHT1;7 expression was restricted in the vascular bundle (VB) sheath and phloem of source leaves as well as in the phloem of regular/diffuse- and enlarged-VBs of nodes. In accordance with this expression pattern, mutation of OsPHT1;7 led to increased and decreased P distribution in source (old leaves) and sink organs (new leaves/panicles), respectively, indicating that OsPHT1;7 is involved in P redistribution. Furthermore, OsPHT1;7 showed an overwhelmingly higher transcript abundance in anthers than other PHT1 members, and ospht1;7 mutants were impaired in P accumulation in anthers but not in pistils or husks. Moreover, the germination of pollen grains was significantly inhibited upon OsPHT1;7 mutation, leading to a &gt;80% decrease in seed-setting rate and grain yield. Taken together, our results provide evidence that OsPHT1;7 is a crucial Pi transporter for Pi transport and recycling within rice plants, stimulating both vegetative and reproductive growth.
Compliance with local travel restrictions and face masks during first phase of COVID-19 pandemic in Ireland: a national survey
Authors: Kearney Patricia M , Spillane Mary , Humphries Rory , Gannon Alannah , Stamenic Danko , Bhuachalla Cliodhna Ni , Hoevel Philipp , Arensman Ella , O’Riordain Micheal , Troya M Isabela , Khashan Ali S , O’Reilly Eilis , Buckley Claire , O’Connor Lois , Perry Ivan J 
Published: January 2022

Abstract

Background
This study examines compliance with local travel restrictions and assesses early uptake of mask wearing, during the initial phase of the coronavirus disease of 2019 (COVID-19) pandemic in Ireland, to inform the ongoing outbreak response.

Methods
A series of four nationally representative telephone surveys were developed. Information was collected at a household level and from primary respondents. Multivariable logistic regression estimated the association between sociodemographic characteristics and compliance with the local travel restriction and with mask use in primary respondents.

Results
Household compliance with local travel restrictions was similar by region, household size and social position. 73.4% of all household members complied, with high levels maintained over time. Higher proportions reported travelling for non-permitted reasons with time. Older age, female gender and attending higher education were independently associated with compliance to local travel restrictions. Among primary respondents, no factors were independently associated with mask use.

Conclusion
High compliance with local travel restrictions during the early stages of the pandemic demonstrates the engagement of the population with public health guidance. Although high compliance with local travel restrictions was generally maintained over time, non-permitted activities increased. Early adoption of mask use before required by national policy or legislation provides further evidence of the responsiveness of the population.
Social policy and labor supply: the impact of activating labor market institutions on reservation wages
Authors: Fuchs Benjamin , Prechsl Sebastian , Wolbring Tobias 
Published: January 2022

Abstract
Activation is an efficacious policy paradigm in modern welfare states. Taking the case of Germany, we study the relationship between the embeddedness of benefit recipients in activating labor market institutions and individual labor supply. Using panel data, we estimate the effects of transitions between key institutional states with different degrees of activation on reservation wages (RWs). We show that RWs react to activation: the transition from gainful employment to unemployment benefit receipt leads to an average decrease of 3.1% in RWs. The transition from gainful employment to welfare benefit receipt—an institutional state with far more rigorous activation—leads to a stronger decrease of 4.9%. Mediation analyses show that the income associated with different institutional states is the predominant mechanism that drives the effect on RWs. However, subjective social status also partly mediates the effect. Implications of these findings for active labor market policies are discussed.
Brain reactivity to emotion persists in NREM sleep and is associated with individual dream recall
Authors: Moyne Maëva , Legendre Guillaume , Arnal Luc , Kumar Samika , Sterpenich Virginie , Seeck Margitta , Grandjean Didier , Schwartz Sophie , Vuilleumier Patrik , Domínguez-Borràs Judith 
Published: January 2022

Abstract
The waking brain efficiently detects emotional signals to promote survival. However, emotion detection during sleep is poorly understood and may be influenced by individual sleep characteristics or neural reactivity. Notably, dream recall frequency has been associated with stimulus reactivity during sleep, with enhanced stimulus-driven responses in high vs. low recallers. Using electroencephalography (EEG), we characterized the neural responses of healthy individuals to emotional, neutral voices, and control stimuli, both during wakefulness and NREM sleep. Then, we tested how these responses varied with individual dream recall frequency. Event-related potentials (ERPs) differed for emotional vs. neutral voices, both in wakefulness and NREM. Likewise, EEG arousals (sleep perturbations) increased selectively after the emotional voices, indicating emotion reactivity. Interestingly, sleep ERP amplitude and arousals after emotional voices increased linearly with participants’ dream recall frequency. Similar correlations with dream recall were observed for beta and sigma responses, but not for theta. In contrast, dream recall correlations were absent for neutral or control stimuli. Our results reveal that brain reactivity to affective salience is preserved during NREM and is selectively associated to individual memory for dreams. Our findings also suggest that emotion-specific reactivity during sleep, and not generalized alertness, may contribute to the encoding/retrieval of dreams.
TubulinTracker, a Novel In Vitro Reporter Assay to Study Intracellular Microtubule Dynamics, Cell Cycle Progression, and Aneugenicity
Authors: Geijer Marit E , Moelijker Nynke , Zhang Gaonan , Derr Remco , Osterlund Torben , Hendriks Giel , Brandsma Inger 
Published: January 2022

Abstract
Aneuploidy is characterized by the presence of an abnormal number of chromosomes and is a common hallmark of cancer. However, exposure to aneugenic compounds does not necessarily lead to cancer. Aneugenic compounds are mainly identified using the in vitro micronucleus assay but this assay cannot standardly discriminate between aneugens and clastogens and cannot be used to identify the exact mode-of-action (MOA) of aneugens; tubulin stabilization, tubulin destabilization, or inhibition of mitotic kinases. To improve the classification of aneugenic substances and determine their MOA, we developed and validated the TubulinTracker assay that uses a green fluorescent protein-tagged tubulin reporter cell line to study microtubule stability using flow cytometry. Combining the assay with a DNA stain also enables cell cycle analysis. Substances whose exposure resulted in an accumulation of cells in G2/M phase, combined with increased or decreased tubulin levels, were classified as tubulin poisons. All known tubulin poisons included were classified correctly. Moreover, we correctly classified compounds, including aneugens that did not affect microtubule levels. However, the MOA of aneugens not affecting tubulin stability, such as Aurora kinase inhibitors, could not be identified. Here, we show that the TubulinTracker assay can be used to classify microtubule stabilizing and destabilizing compounds in living cells. This insight into the MOA of aneugenic agents is important, eg, to support a weight-of-evidence approach for risk assessment, and the classification as an aneugen as opposed to a clastogen or mutagen, has a big impact on the assessment.
Acute liver injury following short-term use of the herbal supplement kratom
Authors: Umbehr Gabriel , Lukaszewicz Magdalena 
Published: January 2022

ABSTRACT
Kratom, a tropical plant and dietary supplement with dose-dependent effects, has physiologic effects similar to opioids as well as stimulant effects. Kratom, like all dietary supplements, is not regulated in the United States and its effects have raised potential and safety concerns. This article describes a patient who presented to the ED with jaundice and acute liver injury, which after a thorough exclusion of alternative causes was attributed to kratom use.
MYC Alteration by Chromothripsis Event in Aggressive High-Grade B-Cell Lymphoma Negative by Conventional Fluorescence In Situ Hybridization Analysis: A Case Report
Authors: Sukhanova Madina , Van Slambrouck Charles , Yap Kai Lee , Smith Sonali M. , Gurbuxani Sandeep , Venkataraman Girish 
Published: January 2022

Abstract
Double-hit and double-expressor phenotypes in lymphomas are characterized by activation of the expression of the MYC and BCL2 genes through diverse mechanisms including chromosomal translocations and amplifications. Herein, we report a high-grade B-cell lymphoma in a patient with evidence for a chromothripsis event (via chromosomal microarray methodology) at chromosome 8, resulting in a focal copy number gain of the MYC locus, not detected by conventional fluorescence in situ hybridization for MYC despite strong MYC expression by immunohistochemical analysis. Chromosome analysis from the biopsy was not successful because of an extensive tissue necrosis. Chromothripsis is suggested as another mechanism for the activation of MYC in non-Hodgkin lymphoma, resulting in aggressive disease course, and this case underscores the need for chromosomal microarray testing in select cases to identify aggressive biology.
Unusual Presentation of Myeloid Sarcoma in a Patient With Usher Syndrome
Authors: Barron Cynthia Reyes , Crane Genevieve Marie 
Published: January 2022

Abstract
A 45-year-old woman with Usher syndrome, associated congenital deafness, progressive blindness due to retinitis pigmentosa, and latent autoimmune diabetes presented to the emergency department with malaise, dizziness, and pelvic pain following removal of an intrauterine device. A posterior vaginal wall mass was found on examination. Laboratory values demonstrated anemia, thrombocytopenia, and an elevated white blood cell count, raising concern for infection and potential onset of diabetic ketoacidosis. This prompted a peripheral blood smear review, which showed 60% monocytic blasts. A subsequent vaginal mass biopsy showed a myeloid sarcoma. Molecular studies demonstrated an NPM1 mutation in exon 12 without FLT3 mutation or internal tandem duplication. While a diagnosis of acute myeloid leukemia with mutated NPM1 was considered, cytogenetics revealed a complex karyotype with evidence of clonal evolution, consistent with acute myeloid leukemia with myelodysplasia-related changes. In addition to an unusual presentation of myeloid sarcoma, this case posed significant questions regarding management and pursuit of hematopoietic stem cell transplantation. Usher syndrome is genetically and clinically heterogeneous. While it is not known to be associated with increased risk of malignancy, mutation of genes associated with Usher syndrome has been identified in acute leukemia. Our case raises the question as to whether potential germline predisposition should be considered in a patient with a previously unassociated congenital syndrome.
Tips and Tricks for Facial Toxin Injections with Illustrated Anatomy
Authors: Swift Arthur , Green Jeremy B. , Hernandez Claudia A. , Aguilera Shino Bay , Fagien Steven , Gold Michael H. , Casabona Gabriela , Frank Konstantin , Nikolis Andreas , Cotofana Sebastian 
Published: January 2022

Learning Objectives:
After studying this article, the participant should be able to: 1. Recognize facial muscle contraction direction and muscle morphology based on skin surface movements and facial rhytides. 2. Classify different muscle contraction patterns and target respectively with the recommended dosage and injection technique. 3. Apply the presented injection techniques to the patients’ individual anatomy with greater precision and without affecting adjacent muscles or causing other adverse events.

Summary:
Facial muscular anatomy has recently gained increased attention, with new investigative methodologies and new injection techniques arising on the market. These recent advancements have increased our understanding about the functional anatomy of facial muscles and have changed the way health care professionals see and understand their interplay during various facial expressions and in determining facial shape. This new anatomical understanding of facial muscles and their interaction has resulted in superior neuromodulator treatment outcomes with fewer side effects and with increased precision. The latter is of greatest importance, as all facial muscles act as a unit and connect with each other. It is therefore paramount to target during neuromodulator treatments only the muscle responsible for the aesthetic effect desired and not other adjacent muscles, which can have different or even antagonistic effects. Conventional anatomy was previously limited to two-dimensional explanations of muscle locations without incorporating their detailed action or their three-dimensional location of extent. The “new” anatomy incorporates those novel concepts and, once understood, will help health care providers to understand better and to “read” the underlying muscular anatomy based on the wrinkle status and based on the change in skin surface landmarks based on the actions of the underlying musculature. The following article summarizes tips and tricks, pearls and pitfalls, and dos and don’ts during facial neuromodulator injections along with a guide toward adverse event management and patient outcome assessment with special focus on the underlying anatomy.
Extensor Pollicis Brevis Transosseous Tenodesis Technique for Treatment of Acquired Metacarpophalangeal Hyperextension Deformity of the Thumb: A Preliminary Report
Authors: Hernández-Cortés Pedro , Hernández-Peregrina Pedro , Pajares-López Miguel , Cigna Emanuele , Sánchez-Montesinos Indalecio , Roda Olga 
Published: January 2022

Summary:
Hyperextension deformity of the metacarpophalangeal joint of the thumb causes pain and loss of function. Although many treatments have been proposed, none of them are universally accepted as ideal. The authors report a study of 12 symptomatic hyperextension deformities of the thumb metacarpophalangeal joint in 10 patients who underwent surgical correction. The purpose of this study was to describe a new technique of tenodesis of the thumb metacarpophalangeal joint using the extensor pollicis brevis tendon. The technique consists of extensor pollicis brevis tenotomy at the wrist and tendon transfer through two bone tunnels to the palmar aspect of the metacarpophalangeal joint before metacarpal fixation with a flexor tenodesis effect. Correction of hyperextension and range of motion were assessed. Functional changes were evaluated by Quick Disabilities of the Arm, Shoulder, and Hand score, pain visual analogue scale, Kapandji opposition scheme, and pinch strength. The Wilcoxon test was used for statistical analysis. Mean preoperative and postoperative metacarpophalangeal joint hyperextension deformities were +50.83 ± 5.57 degrees and −17.91 ± 7.82 degrees, respectively. Thumb opposition improved by one point on Kapandji’s scheme. Mean perceived pain decreased from 7.66 to 1.16. On average, the Quick Disabilities of the Arm, Shoulder, and Hand score was reduced by 34.4 points and pinch strength increased by 50.42 percent. The authors found that extensor pollicis brevis transosseous tenodesis is a safe and minimally invasive method for successfully correcting the functionality and cosmetic appearance of metacarpophalangeal joint hyperextension deformities in posttraumatic and trapeziometacarpal osteoarthritis cases. The patients retained functional active flexion, even in deformities greater than 40 degrees.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, IV.
Perforating Fat Injections for Chronic Plantar Fasciitis: A Randomized, Crossover Clinical Trial
Authors: Gusenoff Beth R. , Minteer Danielle , Gusenoff Jeffrey A. 
Published: January 2022

Summary:
Plantar fasciitis affects 2 million patients per year. Ten percent of cases are chronic, with thickened plantar fascia. Treatment may lead to prolonged recovery, foot instability, and scar. The authors hypothesized that perforating fat injections would decrease plantar fascia thickness, reduce pain, and improve quality of life. Adults with plantar fascia greater than 4 mm for whom standard treatment had failed were included in a prospective, randomized, crossover pilot study. Group 1 (intervention) was followed for 12 months. Group 2 was observed for 6 months, injected, and then followed for 6 months. Validated patient reported outcome measures, ultrasound, and complications were assessed. Group 1 had nine female patients and group 2 had five patients. A total of 2.6 ± 1.6 ml of fat was injected per foot at one to two sites. In group 1, plantar fascia thickness decreased from screening at 6 and 12 months (p < 0.05). Group 2 had decreased plantar fascia thickness from screening to 6 months after injection (p < 0.05). Group 1 had pain improvements at 6 and 12 months compared with screening (p < 0.01). Group 2 reported no pain difference after injections (p > 0.05). Group 1 had improved activities of daily living and sports activity at 6 and 12 months compared with screening (p < 0.003). Group 2 noted increased sports activity 6 months after injection compared with screening (p < 0.03). In conclusion, perforating fat injections for chronic plantar fasciitis demonstrate significant improvement in pain, function, and plantar fascia thickness.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, II.