bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defective migration of monocyte-derived dendritic cells in LAD-1 immunodeficiency
Authors: Fiorini Maurilia , Vermi William , Facchetti Fabio , Moratto Daniele , Alessandri Giulio , Notarangelo Lucia , Caruso Arnaldo , Grigolato Piergiovanni , Ugazio Alberto G , Notarangelo Luigi D , Badolato Raffaele 
Published: September 2022

Abstractβ2 Integrins (CD18) are required for leukocyte migration. In fact, the absence of CD18 results in type-1 leukocyte adhesion deficiency (LAD-1). We analyzed the distribution phenotype and function of dendritic cells (DCs) in three LAD-1 patients with homozygous mutations of CD18. Two of them did not express CD18 (Patients A and C), and the other subject (Patient B) displayed reduced expression of β2 integrins because of a missense mutation. Analysis of DCs derived from Patients A and B showed an abnormal morphology and a severe impairment in transendothelial migration and chemotactic response to CCL19/macrophage inflammatory protein-3β, suggesting that CD18 is required for migration of monocyte-derived DCs. Nevertheless, DCs displayed normal macropinocytosis and underwent normal maturation after addition of tumor necrosis factor α. Finally, immunohistochemical analysis of lymph nodes from subjects B and C revealed a significant reduction in the number of factor-XIIIa+ interstitial DCs in the interfollicular area in both patients, suggesting that CD18 plays a role in the migration of these cells in vivo.
Opening Time, Closing Time: A Journey from Hermes and Hesiod to Vico and Joyce
Authors: Katz Barry M. 
Published: September 2022

AbstractAn intellectual iconoclast, Norman O. Brown was one of the most imaginative contributors to post–World War II cultural theory. His books, grounded in deep classical erudition, include Hermes the Thief (1947), a pioneering attempt to apply Marxist historiography to the evolution of a Greek myth; Life against Death (1959), his acclaimed psychoanalytic reinterpretation of history; Love's Body (1966), an aphoristic questioning of the rationalist foundations of Western civilization; and Closing Time (1973), in which Brown interjects himself into an imagined conversation between eighteenth-century philosopher Giambattista Vico and the writer James Joyce. This essay traces the arc of his intellectual journey from its classical sources (Hermes and Hesiod) to his late confrontation with Vico and Joyce, from which he concluded, “There comes a time—I believe we are in such a time—when civilization has to be renewed by the discovery of new mysteries.”
“The Visual Poetry of the Work”
Authors: Sacks Jeffrey 
Published: September 2022

AbstractThis article addresses the work of the German-language philosopher and theorist Theodor W. Adorno and the Palestinian artist Mona Hatoum in order to ask after the form of the subject and the sense of life privileged in critique. I consider the form of the subject and the sense of the social presumed and generalized in Adorno in relation to his reading of Hegel and his discussion of race, anti-Blackness, anti-Semitism, and “the American landscape” in aphorisms twenty-eight and sixty-eight in Minima Moralia. Drawing on scholarship in Black and Indigenous studies, I argue that in Adorno a particular sense of the subject, with and against Adorno's language, is advanced: the subject of the law, right, property, and whiteness, what one might call the subject of settler life. I suggest that this is a sense of the subject that privileges its ethicality in relation to social violence and world, and I notice that this privilege is constitutive of what critique, for Adorno, is. I then turn to Hatoum and offer a reading of several of her works and installations alongside her discussion of her art in a series of interviews, where I focus on Light at the End (1989), Present Tense (1996), Hair Lines (1979), and Socle du Monde (1992–1993). I study Hatoum's work in order to understand the sense of the social it enlivens, and the sense of being and language it makes manifest, and I argue that, in Hatoum's work, art becomes critique, critique becomes a theorization of the social, and theorization becomes a temporal practice of sociality, an inessential, inidentical sharing in language and form. In Hatoum's art, a sociality of collective form displaces the critical terms of self-possession, self-orientation, and philosophical self-reflection, where property is unmoored as a logic of reading and life and a principle of form.
Yin-Yang tongue sign: An imaging clue of lesions involving the skull base segment in the hypoglossal pathway
Authors: Chen Xuexia , Yi Jingru , Liu Simin , Chen Weiwei , Guan Jian , Pan Chu 
Published: September 2022

Objective: To investigate the diagnostic value of the Yin-Yang tongue sign in patients with tongue deviation. Methods: According to the presence of the Yin-Yang tongue sign on CT/MR, 107 patients with tongue deviation were divided into a positive group and a negative group. The involvement categories of the hypoglossal canal (HC) in the positive group were evaluated and classified as HC dilation and HC erosion. The correlations between HC involvement categories and the presence of the sign were analysed. Results: There were 55 cases (55/107, 51.4%) in the positive group and 52 cases (52/107, 48.6%) in the negative group. Hypoglossal nerve (HN) involvement mainly occurred in the skull base (61.8%), skull base and carotid space (10.9%), and carotid space segment (12.7%). Neurogenic (50.9%), squamous cell carcinoma (14.5%), and metastases (12.7%) were the predominant aetiologies. The sensitivity, specificity, and accuracy of this sign for suggesting skull base lesions around HC were 72.4%, 80.8%, and 76.6%, respectively. In the positive group, HC dilation was seen in 21 patients (21/55, 38.2%) and 21 cases were all benign. HC erosion were noted in 19 patients (19/55, 34.5%), of whom 12 cases were malignant. Conclusion: The Yin-Yang tongue sign is formed by unilateral tongue atrophy and fat infiltration caused by lesions in the HN pathway, especially compressive or invasive lesions involving the skull base segment.
Multi-level classroom learning prepares nurses for future collaboration in palliative care: an educational initiative
Authors: Mason Heidi , Price Deborah M , Bigelow April , Harden Karen 
Published: September 2022

Background: Palliative care (PC) education should be an important part of both the graduate and undergraduate nursing curriculum. Nursing's philosophy of holistic care, which aims to improve the quality of life of patients and families, aligns with the primary objective of PC, positioning nurses to take the lead in expanding and improving PC delivery to all patients with a life-threatening diagnosis. The best way to facilitate this level of care is when staff nurses and advanced practice nurses work collaboratively. Aim: To establish a new standard for nursing education that emphasises intradisciplinary care. Methods: To fill the gap in PC education for nursing students, a dedicated elective PC class was developed for undergraduate and graduate students at a large midwestern University in the United States. Findings: Through an interactive approach to learning, both groups were able to experience and more fully understand how they would work collaboratively with each other to provide high-quality PC. Conclusions: Intradisciplinary PC education is an opportunity for students to learn the precepts of PC in an environment that will mirror their post-graduation practice environment.
Nursing interventions for people in palliative care, based on the Dignity Model
Authors: da Silva Rudval Souza , Mussi Fernanda Carneiro , da Nóbrega Maria Miriam Lima , de Almeida Ana Raquel Lima Peralva , Costa Laura Emmanuela Lima , Pereira Álvaro 
Published: September 2022

Background: The use of the standardised nursing language aims to accurately represent clinical practice, contributing to proper documentation and the creation of evidence-based practice. Aims: To validate nursing interventions (NI) for patients in palliative care, structuring these using the Dignity-Conserving Care Model. Methods: A methodological study was conducted, developed according to the recommendations of the International Council of Nurses (ICN) and anchored in the Dignity-Conserving Care Model. The NI were developed in four stages: 1) construction of NI, based in the International Standards Organisation's standard (18.104:2014); 2) content validation by 26 expert nurses; 3) cross-mapping with the NIs contained in the International Classification for Nursing Practice (ICNP®) catalogue, Palliative Care for Dignified Dying, to identify those already existing in the catalogue; and 4) structuring the NI based on the concepts of the Dignity-Conserving Care Model. Findings: 209 NI were validated and grouped into categories, namely: illness-related concerns; dignity-conservation repertoire; social dignity inventory. Of these, 183 were new and 26 already existed in the ICNP® Catalogue. Conclusion: The study presents new insights into palliative care in Brazil and presents 183 new NI in addition to those already published by the ICN.
The opioid epidemic and the impact on opioid prescribing in hospice and palliative care: a qualitative study
Authors: Borders Joshua , Letvak Susan 
Published: September 2022

Background: In the US, rising rates of opioid abuse has led to regulatory policies designed to curb opioid prescribing. While these policies generally exclude hospice and palliative care from prescribing restrictions, it is not known if these policies have had unintended consequences that affect opioid prescribing within hospice and palliative care. Methods: A qualitative, descriptive design, guided by the Theory of Planned Behaviour, was utilised to conduct a study to answer the following two research questions: 1) How has the opioid epidemic and related policies affected opioid prescribing practises among hospice and palliative care clinicians? and 2) How do hospice and palliative care clinicians perceive patients' end-of-life care has been impacted by the opioid epidemic and related policies? Findings: Ten clinicians, comprising physicians and nurse practitioners working in hospice and palliative care settings, were directly interviewed one-on-one. Data analysis revealed that the opioid epidemic and related policies have had an impact on the patient, clinician, nursing and hospice and palliative care speciality. Conclusions: As the broader medical community shifts away from opioid prescribing, care must be taken to ensure that hospice and palliative care patients still receive access to needed medications. Education is needed to assure that the relief of human suffering at end of life is prioritised.
Dynamics in the Pursuance of Higher Education’s Mandate Amidst Workload Policy: The Optimism for Academics’ Career Growth
Authors: Kaguhangire-Barifaijo Maria 
Published: September 2022

The paper explores multiple challenges encountered by academics in an attempt to fulfil the mandate of higher education institutions in Uganda of; teaching, research and service to community. Whereas teaching is the core function of any university, research and the third mission had majorly been used to inform most personnel decisions, thereby threatening not only quality but academics’ enthusiasm and growth. Two HEIs; Makerere University and Uganda Management Institute (UMI), were purposively selected to unravel the underlying dynamics using a descriptive design. It was revealed that university teaching was the most gratifying profession, and a cardinal role why universities exist, but research was a prerequisite for exception instructional delivery, evidence based teaching, institutional and individual visibility. Similarly, masterly through research was provided effective service to the community. Nonetheless, as individual academics strive to balance the three roles of teaching, research and service, the policy on minimum workload that majorly focuses on teaching load, has remained a hurdle, thereby jeopardizing academics’ career growth and progression. Paradoxically, even those who have endeavored to publish, suffer not only serious burnout and lack of adequate time to prepare for teaching, but their contract renewals that are constantly in jeopardy due to workload deficits. These stringent benchmarked evaluation tools, is threatening not only individual and institutional profiling, but also, diminished professorial collegiate. Further, it is recommended that institutions review their workload perimeters to take into consideration other aspects such as; number of students one has supervised, program development and review, representation on professional bodies and leadership.
Review of Diane Ravitch Book, “The Death and Life of the Great American School System: How Testing and Choice are Undermining Education.” New York, NY: Basic Books.
Authors: Singh Navin K. 
Published: September 2022

AbstractAbstractThe book has eleven chapters that can be clustered into three parts. The first part traces historical accounts of educational reforms in America and their impacts. The second part illuminates some of the major success stories and innovations American education system. The part of the book sheds light on corporatization of education and the ever growing dominance to business and corporate worlds in American education system. This part also gives some perspectives on some of lessons that need to be learned from the past experiments and reforms in American education system.
Medical Humanities Role in Medical Education
Authors: Zimmerman Thomas , Marfuggi Richard 
Published: September 2022

AbstractTwentieth Century medical education has stressed the basic sciences to the neglect of the humanities. The intent of this commentary is to explore the humanities' role and contribution to the professional formation of the physician. A major change on the United States' medical school admission exam starting in 2015 is a move away from its current focus on natural sciences and begins to incorporate a wider breath of liberal studies and social sciences. The ideal 21st Century physician is a more well rounded person who can interact on a deeper level with patients and not by a narrow spectrum of intellectual interests. The 21st Century curriculum has a unique opportunity to reflect and build upon professional values and attributes informed by the humanities, particularly as the latter relate to the role of the physician in society. It is important to be creative in constructing opportunities for humanities learning experiences and resources within the scope and structure of the curriculum. It is necessary to think in more innovative ways as to the experiential learning environment that targets professional formation, and for a more broadly and humanly educated physician.
Do Local Government Units (LGUS) Interact Fiscally While Providing Public Health Services In The Philippines?
Authors: Kelekar Uma 
Published: September 2022

AbstractThe aim of this paper is to better understand the impacts of a decentralized public health delivery system of the Philippines on local government spending. Specifically, it investigates determinants of local government public health expenditures for the year 2007. Within the context of the Philippines' decentralized health system, particular emphasis is given to horizontal fiscal interactions. The research addresses these issues in an empirical spatial econometric framework utilizing public finance local government data. A key finding is the positive fiscal interaction among local governments that is consistent with competition for scarce resources such as doctors, as well as competition among political actors prior to elections. The policy implications of these results are also discussed.
Soil wind erosion resistance analysis for soft rock and sand compound soil: A case study for the Mu Us Sandy Land, China
Authors: Wang Huanyuan , Tong Wei , Liu Jinbao , Han Jichang , Liu Siqi 
Published: September 2022

Abstract
Mixtures of soft rock and sand have been applied extensively in the Mu Us Sandy Land (MUSL, also known as the Mu Us Desert) to limit the loss of top soil by wind erosion. In this study, the efficacy of sand-fixing technology was investigated in a series of experiments. The sand-fixing effect of seven different mixtures (ratios) on soft rock and sand was evaluated in a wind tunnel. The results indicated that the MUSL soils are susceptible to wind erosion, as the textural composition of sand is dominated by coarse particles. MUSL soils dominated by silt and clay particle sizes are more resistant to wind erosion. Each soft rock and sand combination experiences severe wind erosion. However, wind erosion was significantly reduced when soft rock and sand were mixed. An increase in particle size was associated with an increase in the resistance of soft rock and sand mixtures to wind erosion. The ability to resist wind erosion was greatest when the ratio of soft rock and sand was between 1:2 and 1:5. This study provided data to support the approaches to sand-fixing commonly used at present in the MUSL. The results of this study have important practical significance for the improvement of agricultural land potential in dry sandy areas.
Analysis of land use change on urban landscape patterns in Northwest China: A case study of Xi’an city
Authors: Zhao Yizhen , Cao Jiannong , Wang Wenyu , Zhang Xiaodong 
Published: September 2022

Abstract
Xi’an, an inland city in Northwest China, borders the Qinling Mountains to the south and Wei River to the north. This city is rich in biodiversity and occupies a unique position in China. In the past few decades, human activities have led to great changes in land use in Xi’an city, and the ecosystem has experienced an accelerated fragmentation process. This study analyzed the degree of land use change and landscape fragmentation in the region. Land use data in 1990, 2000, 2010, and 2018 were used to evaluate the effects of land use change on the landscape pattern in Xi’an city at different scales using mathematical models and landscape indices. Results show that from 1990 to 2018, built-up land expanded the most, from 7.34 to 13.51%. Cropland decreased the most, from 40.12 to 29.81%. Overall, the fragmentation degree of cropland patches decreased, and the fragmentation degree of built-up land patches increased. The landscape patterns of different districts and counties show different change directions. The results can provide necessary information for land use planning and land resource allocation in inland cities in Northwest China.
miR-146-5p restrains calcification of vascular smooth muscle cells by suppressing TRAF6
Authors: Yang Jing , Zhou Xiaoman , Lu Jingwei , Li Meng 
Published: September 2022

Abstract
Vascular calcification is a prominent manifestation of advanced atherosclerosis. Tumor necrosis factor-receptor-associated factors (TRAFs) were reported to participate in atherosclerosis development. In this study, the role and mechanism of TRAF6 in vascular calcification were explored. To induce the vascular calcification, oxidized low-density lipoprotein (Ox-LDL) was applied to treat vascular smooth muscle cells (VSMCs). TRAF6 protein expression in VSMCs was assessed by western blotting. Osteogenic differentiation of VSMCs was assessed by alkaline phosphatase activity analysis. Mineral deposition in VSMCs was evaluated by von Kossa staining. VSMC proliferation, migration, apoptosis, inflammation, and reactive oxygen species (ROS) generation were detected using cell counting kit-8, Transwell, flow cytometry, reverse transcriptase quantitative polymerase chain reaction (RT-qPCR), and dichlorodihydrofluorescein diacetate staining, respectively. Luciferase reporter assay was utilized to identify the binding relationship between miR-146-5p and TRAF6 in VSMCs. We found that Ox-LDL administration induced the calcification of VSMCs and elevated the TRAF6 level. TRAF6 knockdown restrained VSMC calcification, proliferation, migration, inflammation, and ROS generation caused by Ox-LDL. Mechanically, TRAF6 was targeted by miR-146-5p in VSMCs. Furthermore, TRAF6 overexpression offset the inhibitory effects of miR-146-5p upregulation on vascular calcification in VSMCs under the Ox-LDL condition. Overall, miR-146-5p restrains the calcification of VSMCs by suppressing TRAF6.
A new cadmium(ii) coordination polymer with 1,4-cyclohexanedicarboxylate acid and phenanthroline derivate: Synthesis and crystal structure
Authors: Su Beihao , Shi Yihan , Peng Xuehan , Kong Zhiguo , Chang Limin 
Published: September 2022

Abstract
A new Cd(ii) coordination polymers, formulated as [Cd(1,4-chdc)(L)]
n
(1) (L = 1-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)naphthalen-2-ol ligands and 1,4-H2chdc = 1,4-cyclohexanedicarboxylate acid), were successfully synthesized by using L ligand and 1,4-H2chdc acid under hydrothermal conditions and characterized by single crystal X-ray elemental analyses, diffraction, and IR spectroscopy. Each Cd(ii) atom is a distorted pentagonal bipyramidal geometry connecting the deprotonated 1,4-chdc anion to form a 2D layer, and a 2D layer is formed into a 3D supramolecular structure by the π–π stacking interactions between neighboring layers.
Phthalate exposure and lung disease: the epidemiological evidences, plausible mechanism and advocacy of interventions
Authors: Yu Yun , Wang Jian Qing 
Published: September 2022

Abstract
Phthalates are a kind of synthetic plasticizers, which extensively used as plastic productions to improve their plasticity and flexibility. However, exposure to phthalates has been proved an increased risk of respiratory disease, because by they affect the development and functions of the lung and immune system. Here, we attempt to review respiratory health of phthalate exposure. Firstly, we describe the relationship between phthalates and lung function and airway inflammation. Then, the role of phthalates in asthma, lung cancer, rhinitis, and respiratory tract infections and the possible mechanisms of action are discussed. Finally, possible effective measures to reduce exposure to phthalates are proposed, and health care workers are called upon to provide educational resources and advocate for informed public health policies. Overall, the evidence for association between phthalate exposure and respiratory disease is weak and inconsistent. Therefore, thorough implementation in large populations is needed to produce more consistent and robust results and to enhance the overall understanding of the potential respiratory health risks of phthalate in long-term exposure.