bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between public health nurses' involvement in local healthcare planning and the corresponding off‐the‐job training
Authors: Yoshioka‐Maeda Kyoko , Shiomi Misa , Katayama Takafumi , Hosoya Noriko , Fujii Hitoshi , Mayama Tatsushi 
Published: September 2022

AbstractObjectiveThis study investigated the association between receiving off‐the‐job training and the involvement of public health nurses in local healthcare planning.DesignA nationwide, cross‐sectional study design.MethodsWe sent self‐report questionnaires to 2,185 public health nurses with experience in developing local healthcare plans in Japan since 2013 and collected information related to three main categories: demographic data, involvement in local healthcare planning and strategies for healthcare planning.ResultsWe received 1,281 responses (return rate of 58.6%), of which 231 did not meet the inclusion criteria. Thus, we analysed 1,050 valid responses. Among the 1,050 respondents, 496 (47.2%) had received off‐the‐job training in healthcare planning. A subsequent logistic regression analysis revealed that the following factors were associated with this achievement: holding a managerial position, receiving healthcare planning education at the undergraduate level, having mentors regarding the promotion of it, partially conducting cross‐sectional coordination and conducting groupwork with community‐dwelling residents.
Rhabdomyosarcoma with unknown primary tumor site: A report from European pediatric Soft tissue sarcoma Study Group (EpSSG)
Authors: Affinita Maria Carmen , Merks Johannes H. M. , Chisholm Julia C. , Haouy Stèphanie , Rome Angelique , Rabusin Marco , Brennan Bernadette , Bisogno Gianni 
Published: September 2022

AbstractBackgroundRhabdomyosarcoma (RMS) is an aggressive malignancy, and 20% of children present with metastases at diagnosis. Patients presenting with disseminated disease very occasionally have no clear evidence of a primary tumor mass. As these patients have rarely been investigated, we report on a series of patients with RMS and unknown primary tumor site registered in the Metastatic (MTS) RMS 2008 protocol (October 2008 to December 2016) coordinated by the European pediatric Soft tissue sarcoma Study Group.MethodsPatients were administered nine cycles of induction chemotherapy, and 48 weeks of maintenance chemotherapy. Surgery and/or radiotherapy were planned after the first assessment of tumor response, and implemented after six cycles of chemotherapy. If feasible, radiotherapy to all sites of metastasis was recommended.ResultsWe identified 10 patients with RMS and unknown primary site, most of them adolescents (median age 15.8 years, range: 4.6–20.4). Nine had fusion‐positive alveolar RMS. Multiple organ involvement was identified in seven patients, two only had bone marrow disease, and one only had leptomeningeal dissemination. All patients were given chemotherapy, four were irradiated, and none had surgery. Three patients underwent allogeneic bone marrow transplantation. At the time of this analysis, only two patients are alive in complete remission: one had received radiotherapy; and one had a bone marrow transplant.ConclusionsRMS with unknown primary tumor occurs mainly in adolescents and is typically fusion‐positive alveolar. Radiotherapy may be important, but survival is poor and patients should be offered enrollment in investigational trials.
Quantifying the linguistic demands of the oral directions of preschool cognitive assessments
Authors: Graves Scott L. , Johnson Kyanna , Phillips Shanye , Jones Mark , Jacobs Marcel 
Published: September 2022

AbstractResearch has indicated that school aged (6–16 years) versions of cognitive assessment instruments have varying levels of linguistic demand, which could impact assessment results for placement purposes. However, a significant limitation to this research is the fact that it has not been replicated with cognitive assessment instruments used in preschool populations. As such, the purpose of this study is to address this gap in the research literature by examining linguistic demands of cognitive test batteries used for preschool aged children. The Kaufman Assessment Battery for Children, Second Edition (KABC‐II), Woodcock Johnson Test of Cognitive Abilities Fourth Edition (WJ Cog‐IV), and the Wechsler Preschool and Primary Scale of Intelligence Fourth Edition were used for this examination. Overall results demonstrated that the oral directions of preschool assessments have relatively low linguistic demands. However, several subtests on WJ Cog‐IV have high Complexity, Verbosity, and Total Demand indices, which can pose difficulty for students with limited word knowledge. Furthermore, the KABC‐II was the least demanding assessment from a linguistic standpoint. Implications are discussed in terms of the assessment of early childhood populations.
JUMPptm: Integrated software for sensitive identification of post‐translational modifications and its application in Alzheimer's disease study
Authors: Poudel Suresh , Vanderwall David , Yuan Zuo‐Fei , Wu Zhiping , Peng Junmin , Li Yuxin 
Published: September 2022

AbstractBackground: Mass spectrometry (MS)‐based proteomic analysis of posttranslational modifications (PTMs) usually requires the pre‐enrichment of modified proteins or peptides. However, recent ultra‐deep whole proteome profiling generates millions of spectra in a single experiment, leaving many unassigned spectra, some of which may be derived from PTM peptides.Methods: Here we present JUMPptm, an integrative computational pipeline, to extract PTMs from unenriched whole proteome. JUMPptm combines the advantages of JUMP, MSFragger and Comet search engines, and includes de novo tags, customized database search and peptide filtering, which iteratively analyzes each PTM by a multi‐stage strategy to improve sensitivity and specificity.Results: We applied JUMPptm to the deep brain proteome of Alzheimer's disease (AD), and identified 34,954 unique peptides with phosphorylation, methylation, acetylation, ubiquitination, and others. The phosphorylated peptides were validated by enriched phosphoproteome from the same sample. TMT‐based quantification revealed 482 PTM peptides dysregulated at different stages during AD progression. For example, the acetylation of numerous mitochondrial proteins is significantly decreased in AD. A total of 60 PTM sites are found in the pan‐PTM map of the Tau protein.Conclusion: The JUMPptm program is an effective tool for pan‐PTM analysis and the resulting AD pan‐PTM profile serves as a valuable resource for AD research.
Isobaric labeling: Expanding the breadth, accuracy, depth, and diversity of sample multiplexing
Authors: Paulo Joao A. 
Published: September 2022

AbstractIsobaric labeling has rapidly become a predominant strategy for proteome‐wide abundance measurements. Coupled to mass spectrometry, sample multiplexing techniques using isobaric labeling are unparalleled for profiling proteins and posttranslational modifications across multiple samples in a single experiment. Here, I highlight aspects of isobaric labeling in the context of expanding the breadth of multiplexing, improving quantitative accuracy and proteome depth, and developing a wide range of diverse applications. I underscore two facets that enhance quantitative accuracy and reproducibility, specifically the availability of quality control standards for isobaric labeling experiments and the evolution of data acquisition methods. I also emphasize the necessity for standardized methodologies, particularly for emerging high‐throughput workflows. Future developments in sample multiplexing will further strengthen the importance of isobaric labeling for comprehensive proteome profiling.
Substituent effects on the stretching vibration frequencies of C=C bridge bond in aryl ethylene with furyl or thienyl group
Authors: Wang Linyan , Cao Chaotun , Qu Junyan , Cao Chenzhong 
Published: September 2022

AbstractTo explore the substituent effects on the stretching vibration frequencies νC=C of C=C bridge bond in 1‐furyl/thienyl‐2‐aryl ethylene XCH=CHArYs, 60 samples of XCH=CHArYs were synthesized, and their infrared absorption spectra were recorded. The regression analyses between the νC=C values of XCH=CHArYs and the substituent parameters of X and Y were made in detail. Finally, an optimality equation (shown as Equation 3) quantifying the νC=C values of XCH=CHArYs was obtained. It shows that the substituent effects on the νC=C values of XCH=CHArYs mainly reflect in Hammett constant of X and the excited‐state substituent constants of X and Y. Among the parameters in Equation (3), the excited‐state substituent constant of X contributes the most to the νC=C values of XCH=CHArYs as seen from the fraction contributions. On the whole, the contribution of X to the νC=C values of XCH=CHArYs is larger than that of Y.
The investigation of solid and hollow electrode APPJs in discharge characteristics and anticancer effects
Authors: Qi Miao , Peng Sansan , Fan Runze , Zhang Xinying , Pang Bolun , Liu Zhijie , Zhang Hao , Liu Dingxin , Xu Dehui , Kong Michael G. 
Published: September 2022

AbstractCold atmospheric pressure plasmas (CAPs) have a promising application in cancer treatment, the needle‐ring electrodes plasma jet is one of the common CAPs sources. Here, we compared the discharge characteristics and anticancer effects in two plasma jets: solid electrode and hollow electrode with six working gases (He, He + 0.5%O2, He + 0.5%N2, Ar, Ar + 0.5%O2, and Ar + 0.5%N2). The results show the solid plasma jet is slightly stronger according to discharge image, optical emission spectroscopy, and concentration of H2O2and NO2−. We used the leukemia cell THP‐1 as the model to detect the anticancer effect, cell viability assay demonstrated a solid electrode plasma jet with He + 0.5%N2 has less cell survival. Moreover, apoptosis increased significantly as the plasma treatment time and Cleaved‐PARP1 upregulated, SOD1 and p21 downregulated in a time‐dependent manner. Our work suggested that a solid electrode plasma jet with He + 0.5%N2may be a novel therapeutic method for acute myeloid leukemia.
Wettability and water‐droplet contact electrification of nanostructural polypropylene (PP) by plasma modification
Authors: Li Yupeng , Liu Yuxia , Guo Zhen , Huo Lei , Lei Mingkai 
Published: September 2022

AbstractThe superhydrophobic surfaces with three kinds of nanopillars on polypropylene (PP) substrates are fabricated by a plasma nanotexturing technique comprising oxygen‐plasma treatment (OPT) followed by fluorocarbon polymer deposition (FPD). The diameters of nanopillars and spacing distances between nanopillars are tuned under the different OPT and FPD duration times. The wettability and contact electrification on the surfaces are analyzed under the water droplet impact by changing the impacting droplet number, Weber number, and salt concentration. The dense or wide nanopillars favor high contact charge on the surfaces with nanopillars, arousing the damage of the superhydrophobicity with low adhesion. The low contact charge impacting the droplets with high salt concentration has a weakened effect on the superhydrophobicity of the surfaces with nanopillars.
Multi‐stage evolution of frost‐induced microtextures on the surface of quartz grains—An experimental study
Authors: Górska Martyna E. , Woronko Barbara 
Published: September 2022

AbstractCoarse sand‐sized (0.5–1.0 mm) grains of vein quartz were subjected to frost‐induced stress under controlled laboratory conditions. A total of 1,000 freeze–thaw (FT) cycles, simulated under different (low, high) water mineralization conditions in the temperature range from −5°C up to +10°C, were used to test effects on collected samples. Scanning electron microscopic (SEM) microtextural analysis of grain surfaces was performed at 0 (start) and after 50, 100, 300, 700, and 1,000 FT cycles. The results indicate that variable frost‐induced microtextural imprints encountered on quartz grain surfaces prior to and following analysis depend largely on the mineralization (dissolved solute content) of water involved in the weathering process. The higher the water mineralization, the greater the intensity of mechanical weathering. Two predominant outcomes in the course of these micro‐scale frost weathering tests have been identified: a physical (mechanical) aspect manifested by the occurrence of conchoidal fractures and breakage block microtextures dominating up to 300 FT cycles, and a chemical aspect resulting in the occurrence of precipitation crusts and obliteration of grain microrelief. Moreover, three additional stages of microtexture development may be distinguished with the evolution of frost‐induced microrelief on the surface of quartz grains: (i) initial cracks of large‐sized conchoidal fractures, (ii) increasing frost cycles yielding additional small‐sized conchoidal fractures, and (iii) advanced breakage blocks. Frost‐induced exposure of fresh, unweathered grain surfaces leads to refreshing of the grain surface.
Unprotonatable and ROS‐Sensitive Nanocarrier for NIR Spatially Activated siRNA Therapy with Synergistic Drug Effect
Authors: Deng Shaohui , Wang Shiyin , Xiao Zecong , Cheng Du 
Published: September 2022

AbstractAlthough small interfering RNA (siRNA) therapy has achieved great progress, unwanted gene inhibition in normal tissues severely limits its extensive clinical applications due to uncontrolled siRNA biodistribution. Herein, a spatially controlled siRNA activation strategy is developed to achieve tumor‐specific siRNA therapy without gene inhibition in the normal tissues. The quaternary ammonium moieties are conjugated to amphiphilic copolymers via reactive oxygen species (ROS)‐sensitive thioketal (TK) linkers for co‐delivery of siRNA and photosensitizer chlorin e6 (Ce6), showing excellent siRNA complexation capacity and near infrared (NIR)‐controlled siRNA release. In the normal tissue, siRNAs are trapped and degraded in the endo‐lysosomes due to the unprotonatable property of quaternary ammonium moiety, showing the siRNA activity “off” state. When NIR irradiation is spatially applied to the tumor tissue, the NIR irradiation/Ce6‐induced ROS trigger siRNA endo‐lysosomal escape and cytosolic release through the photochemical internalization effect and cleavage of TK bonds, respectively, showing the siRNA activity “on” state. The siRNA‐mediated glutathione peroxidase 4 gene inhibition enhances ROS accumulation. The synergistic antitumor activity of Ce6 photodynamic therapy and gene inhibition is confirmed in vivo. Spatially controlled tumor‐specific siRNA activation and co‐delivery with Ce6 using unprotonatable and ROS‐sensitive cationic nanocarriers provide a feasible strategy for tumor‐specific siRNA therapy with synergistic drug effects.
Magnetic Composite Rapidly Treats Staphylococcus aureus‐Infected Osteomyelitis through Microwave Strengthened Thermal Effects and Reactive Oxygen Species
Authors: Jin Liguo , Zheng Yufeng , Liu Xiangmei , Zhang Yu , Li Zhaoyang , Liang Yanqin , Zhu Shengli , Jiang Hui , Cui Zhenduo , Wu Shuilin 
Published: September 2022

AbstractIt is difficult to effectively treat bacterial osteomyelitis using photothermal therapy or photodynamic therapy due to poor penetration of light. Here, a microwave (MW)‐excited magnetic composite of molybdenum disulfide (MoS2) / iron oxide (Fe3O4) is reported for the treatment of bacteria‐infected osteomyelitis. In in vitro and in vivo experiments, MoS2/Fe3O4 is shown to effectively eradicate bacteria‐infected mouse tibia osteomyelitis, due to MW thermal enhancement and reactive oxygen species (ROS) (1O2 and ·O2–) production under MW radiation. In addition, the mechanism of MW heat generation is proposed by MW network vector analysis. By the density functional theory and finite element method, the ROS generation mechanism is proposed. The synergy or conductive network between dielectric MoS2 and magnetic Fe3O4 can reach both enhancement of the dielectric and magnetic attenuation capability. In addition, abundant interfaces are generated to enhance the attenuation of electromagnetic waves by MoS2 and Fe3O4, introducing multiple reflections and interfacial polarization. Therefore, MoS2/Fe3O4 has excellent MW absorption ability based on the synergy or conductive network between MoS2 and magnetic Fe3O4 as well as multiple dielectric reflections and interfacial polarization.
High Performance and Long‐cycle Life Rechargeable Aluminum Ion Battery: Recent Progress, Perspectives and Challenges
Authors: Abu Nayem S. M. , Ahmad Aziz , Shaheen Shah Syed , Saeed Alzahrani Atif , Saleh Ahammad A. J. , Aziz Md. Abdul 
Published: September 2022

AbstractThe rising energy crisis and environmental concerns caused by fossil fuels have accelerated the deployment of renewable and sustainable energy sources and storage systems. As a result of immense progress in the field, cost‐effective, high‐performance, and long‐life rechargeable batteries are imperative to meet the current and future demands for sustainable energy sources. Currently, lithium‐ion batteries are widely used, but limited lithium (Li) resources have caused price spikes, threatening progress toward cleaner energy sources. Therefore, post‐Li, batteries that utilize highly abundant materials leading to cost‐effective energy storage solutions while offering desirable performance characteristics are urgently needed. Aluminum‐ion battery (AIB) is an attractive concept that uses highly abundant aluminum while offering a high theoretical gravimetric and volumetric capacity of 2980 mAh g−1and 8046 mAh cm−3, respectively. As a result, intensified efforts have been made in recent years to utilize numerous electrolytes, anodes, and cathode materials to improve the electrochemical performance of AIBs, and potentially create high‐performance, low‐cost, and safe energy storage devices. Herein, recent progress in the electrolyte, anode, and cathode active materials and their utilization in AIBs and their related characteristics are summarized. Finally, the main challenges facing AIBs along with future directions are highlighted.
Schizosaccharomyces pombe Sls1 is primarily required for cox1 mRNA translation
Authors: Wang Yirong , Luo Ying , Huang Ying 
Published: September 2022

AbstractMitochondrial DNA (mtDNA) encodes essential subunits of the oxidative phosphorylation (OXPHOS) complexes; thus, the expression of mtDNA‐encoded genes is essential for the synthesis of adenosine triphosphate. However, factors involved in mitochondrial translation have not been fully characterized. In this study, we characterized Schizosaccharomyces pombe Sls1, which has sequence similarity to Saccharomyces cerevisiae Sls1 that is required for the translation of all mtDNA‐encoded messenger RNAs (mRNAs). Deletion of S. pombe sls1 severely impaired the growth of the cells on a rich medium containing the nonfermentable carbon source glycerol, which requires mitochondrial respiration. We found that the translation of mtDNA‐encoded Cox1, the largest subunit of the cytochrome c oxidase complex, was severely impaired in Δsls1 cells. Deletion of S. pombe sls1 also resulted in a barely detectable steady‐state level of mature cox1 mRNA. RNA immunoprecipitation showed that S. pombe Sls1 interacts with cox1 mRNA. Sucrose gradient sedimentation analysis revealed that S. pombe Sls1 is associated with the small subunit of mitochondrial ribosomes. Our results suggest that unlike S. cerevisiae Sls1, S. pombe Sls1 is primarily required for the accumulation and translation of cox1 mRNA.
Pay No Attention to the Model Behind the Curtain
Authors: Stark Philip B. 
Published: September 2022

AbstractMany widely used models amount to an elaborate means of making up numbers—but once a number has been produced, it tends to be taken seriously and its source (the model) is rarely examined carefully. Many widely used models have little connection to the real-world phenomena they purport to explain. Common steps in modeling to support policy decisions, such as putting disparate things on the same scale, may conflict with reality. Not all costs and benefits can be put on the same scale, not all uncertainties can be expressed as probabilities, and not all model parameters measure what they purport to measure. These ideas are illustrated with examples from seismology, wind-turbine bird deaths, soccer penalty cards, gender bias in academia, and climate policy.
Shrinking target equidistribution of horocycles in cusps
Authors: Tseng Jimmy 
Published: September 2022

AbstractConsider a shrinking neighborhood of a cusp of the unit tangent bundle of a noncompact hyperbolic surface of finite area, and let the neighborhood shrink into the cusp at a rate of $$T^{-1}$$

T

-
1

as $$T \rightarrow \infty $$

T
→
∞

. We show that a closed horocycle whose length $$\ell $$
ℓ
goes to infinity or even a segment of that horocycle becomes equidistributed on the shrinking neighborhood when normalized by the rate $$T^{-1}$$

T

-
1

provided that $$T/\ell \rightarrow 0$$

T
/
ℓ
→
0

and, for any $$\delta >0$$

δ
>
0

, the segment remains larger than $$\max \left\{ T^{-1/6},\left( T/\ell \right) ^{1/2}\right\} \left( T/\ell \right) ^{-\delta }$$

max

T

-
1
/
6

,

T
/
ℓ

1
/
2

T
/
ℓ

-
δ

. We also have an effective result for a smaller range of rates of growth of T and $$\ell $$
ℓ
. Finally, a number-theoretic identity involving the Euler totient function follows from our technique.
Exponential mixing of geodesic flows for geometrically finite hyperbolic manifolds with cusps
Authors: Li Jialun , Pan Wenyu 
Published: September 2022

AbstractLet $$\Gamma $$
Γ
be a geometrically finite discrete subgroup in $${\text {SO}}(d+1,1)^{\circ }$$

SO

(
d
+
1
,
1
)

∘

with parabolic elements. We establish exponential mixing of the geodesic flow on the unit tangent bundle $${\text {T}}^1(\Gamma \backslash {\mathbb {H}}^{d+1})$$

T

1

(
Γ
\

H

d
+
1

)

with respect to the Bowen–Margulis–Sullivan measure, which is the unique probability measure on $${\text {T}}^1(\Gamma \backslash {\mathbb {H}}^{d+1})$$

T

1

(
Γ
\

H

d
+
1

)

with maximal entropy. As an application, we obtain a resonance-free region for the resolvent of the Laplacian on $$\Gamma \backslash {\mathbb {H}}^{d+1}$$

Γ
\

H

d
+
1

. Our approach is to construct a coding for the geodesic flow and then prove a Dolgopyat-type spectral estimate for the corresponding transfer operator.
Regularity Criteria for the Kuramoto–Sivashinsky Equation in Dimensions Two and Three
Authors: Larios Adam , Rahman Mohammad Mahabubur , Yamazaki Kazuo 
Published: September 2022

AbstractWe propose and prove several regularity criteria for the 2D and 3D Kuramoto–Sivashinsky equation, in both its scalar and vector forms. In particular, we examine integrability criteria for the regularity of solutions in terms of the scalar solution $$\phi $$
ϕ
, the vector solution $$u\triangleq \nabla \phi $$

u
≜
∇
ϕ

, as well as the divergence $$\text {div}(u)=\Delta \phi $$

div
(
u
)
=
Δ
ϕ

, and each component of u and $$\nabla u$$

∇
u

. We also investigate these criteria computationally in the 2D case, and we include snapshots of solutions for several quantities of interest that arise in energy estimates.
Relative Persistent Homology
Authors: Blaser Nello , Brun Morten 
Published: September 2022

AbstractThe alpha complex efficiently computes persistent homology of a point cloud $$X$$
X
in Euclidean space when the dimension $$d$$
d
is low. Given a subset $$A$$
A
of $$X$$
X
, relative Čech persistent homology can be computed as the persistent homology of the relative Čech complex $${\check{\mathrm{C}}}(X, A)$$

C
ˇ

(
X
,
A
)

. However, this is not computationally feasible for larger point clouds $$X$$
X
. The aim of this note is to present a method for efficient computation of relative Čech persistent homology in low dimensional Euclidean space. We introduce the relative Delaunay–Čech complex $${\text {Del}\check{\mathrm{C}}}(X, A)$$

Del

C
ˇ

(
X
,
A
)

whose homology is the relative Čech persistent homology. It is constructed from the Delaunay complex of an embedding of $$X$$
X
in $$(d+1)$$

(
d
+
1
)

-dimensional Euclidean space.