bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alterations of Gut Microbiome and Fecal Fatty Acids in Patients With Polycystic Ovary Syndrome in Central China
Authors: Li Gailing , Liu Zhenguo , Ren Fang , Shi Huirong , Zhao Qian , Song Yi , Fan Xunjie , Ma Xiaojun , Qin Guijun 
Published: July 2022

ObjectiveThe purpose of this study was to elucidate the characteristics of the gut microbiome in patients with Polycystic ovary syndrome (PCOS) and analyze the alterations of fecal fatty acid metabolism, so as to further provide the pathogenesis of PCOS.MethodsFecal samples from the PCOS group (n = 31) and healthy control group (n = 27) were analyzed by 16S rRNA gene sequencing and untargeted metabolomics. Peripheral venous blood was collected to measure serum inflammation and intestinal permeability. Finally, the correlation analysis of intestinal flora, fecal metabolites, and laboratory indicators was carried out.ResultsSerum D-lactate content in the PCOS group was higher than that in the control group. There was no significant difference in microbial α diversity and β diversity between PCOS patients and healthy controls. Peptostreptococcaceae and Bacteroidales S24-7 group existed significant differences between PCOS patients and healthy controls. Based on linear discriminant analysis selection, 14 genera including Klebsiella, Enterobacteriaceae, and Gammaproteobacteria were dominant in patients with PCOS, while 4 genera, including rumenococcus (Ruminocaccaceae UCG 013), prewortella (Prevotellaceae UCG 001), and erysipelas (Erysipelatoclostridium), were dominant in healthy controls. Compared with PCOS with Body mass index (BMI) &lt; 24, patients with BMI ≥ 24 have multiple dominant genera including Abiotrophia and Peptostreptococcaceae. Moreover, serum levels of free testosterone and androstenedione were positively correlated with Megamonas, while total testosterone was negatively correlated with Alistipes. Additionally, fecal contents of acetic acid and propionic acid in patients with PCOS were significantly higher than those in healthy controls. Eubacterium_coprostanoligenes_group and Alistipes were positively correlated with 6 kinds of fatty acids.ConclusionSpecific intestinal flora fecal fatty acids and serum metabolites may mediate the occurrence and development of PCOS. PCOS patients with different body sizes have specific intestinal flora.
Efficacy of Traditional Chinese Exercise in Improving Gait and Balance in Cases of Parkinson's Disease: A Systematic Review and Meta-analysis
Authors: Wu Minmin , Tang Qiang , Wang Linjing , Zhang Mei , Song Wenjing , Teng Lili , Zhu Luwen 
Published: July 2022

BackgroundThe efficacy of traditional Chinese exercise (TCE)-based intervention in the improvement of motor function in patients with Parkinson's disease (PD) is controversial. The present study aimed to assess the effects of TCE on balance and gait outcomes, as well as motor symptoms in individuals with PD, and evaluate potential discrete moderators such as TCE dosage-related variables.MethodPubMed, Embase, Cochrane's Library, Web of Science, Medline, and Scopus were systematically searched from their dates of inception to February 2022. All studies were randomized controlled trials (RCTs) of TCE-based interventions for PD. The treatment effects were estimated using a random-effect meta-analysis model with standardized mean differences (Hedges' g). The Physiotherapy Evidence Database was used to evaluate the methodological quality of the study.ResultFifteen studies involving a total of 873 participants were included in the final analysis. The meta-analytic findings revealed significant improvements in balance outcomes [Berg Balance Scales (BBS) (g = 0.83, 95% CI = 0.37–1.29, p = 0.000, I2 = 84%), time up and go (TUG) (g = −0.80, 95% CI = −1.13– −0.47, p = 0.000, I2 = 81%), and the one legged blind balance test (g = 0.49, 95% CI = 0.13–0.86, p = 0.01, I2 = 10%)], as well as gait outcomes [gait velocity (g = 0.28, 95% CI = 0.02–0.54, p = 0.04, I2 = 64%), 6-min walking test (6MWT) (g = 0.32, 95% CI 0.01–0.62, p = 0.04, I2= 15%), stride length (g = 0.25, 95% CI = 0.08–0.41, p = 0.003, I2 = 42%)], and motor symptoms [Unified Parkinson's Disease Rating Scale part III (UPDRS-III) (g = −0.77, 95% CI = −1.06– −0.48, p = 0.000, I2 = 76%)]. However, cadence (g = −0.03) and step length (g = 0.02) did not differ significantly. The moderator shows that the effects of TCE on BBS and gait velocity were moderated by Pedro score, exercise type, control group type, and number of sessions. Meta-regression found that TCE (exercise duration, number of sessions, and session duration) was significantly associated with improved UPDRS-III and BBS scores.ConclusionThese findings provide evidence for the therapeutic benefits of TCE as an adjunct therapy for patients with PD. TEC dosage (high-intensity long sessions) may moderate some favorable effects.Systematic Review RegistrationPROSPERO, identifier CRD42022314686.
Adjuvant Radiotherapy Versus Surveillance for Grade 2 Intracranial Meningiomas: A Multi-Institutional Propensity Score-Matched Study
Authors: Byun Hwa Kyung , Chang Won Ick , Lee Joo Ho , Park Chul-Kee , Kim In Ah , Kim Chae-Yong , Cho Jaeho , Kim Eui Hyun , Chang Jong Hee , Kang Seok-Gu , Moon Ju Hyung , Lee Sang Hyung , Lee Jason Joon Bock , Kim Il Han , Suh Chang-Ok , Wee Chan Woo , Yoon Hong In 
Published: July 2022

PurposeWe aimed to compare the outcomes of adjuvant radiotherapy (ART) and surveillance in patients with grade 2 meningiomas (MNG2) who underwent surgical resection.Materials and MethodsData from four hospitals, in which patients aged ≥18 years underwent Simpson grade 1−4 surgical resection for newly diagnosed MNG2 between 1998 and 2018, were examined in this multicenter retrospective cohort study. Patients receiving ART with conventional fractionation were compared with those undergoing surveillance. Progression-free survival (PFS), progression/recurrence (P/R) were evaluated.ResultsThis study included 518 patients, 158 of whom received ART. The median follow-up duration was 64.9 months. In the total cohort, ART was independently associated with significantly improved PFS (HR, 0.35; 95% CI, 0.23–0.55; P&lt;0.001) and P/R (HR, 0.30; 95% CI, 0.18–0.48; P&lt;0.001). In the propensity score-matched cohort (n=143 in each group), the 5-year PFS rates were 80.8% and 57.7% (P=0.004), and the 5-year P/R rates were 16.5% and 40.0% (P=0.002) in the ART and surveillance groups, respectively. After gross total resection, the 5-year PFS (85.0% vs. 64.7%; P=0.020) and P/R rates (15.2% vs. 32.0%; P=0.035) were significantly better in the ART group than in the surveillance group. A model for P/R was developed using recursive partitioning analysis with surgical extent, tumor size, and Ki-67 index. ART reduced the risk of P/R in the low- (P=0.069), intermediate- (P=0.044), and high-risk groups (P&lt;0.001). Local control was also significantly enhanced by ART among all the risk groups (all P&lt;0.05).ConclusionsART significantly improved PFS and P/R in patients with MNG2, irrespective of the surgical extent, and can be recommended after gross total resection. A prognostic model may guide decision-making for the use of ART.
Metabolic Syndrome Predicts Response to Neoadjuvant Chemotherapy in Breast Cancer
Authors: Lu Ying , Wang Pinxiu , Lan Ning , Kong Fei , Abdumijit Awaguli , Tu Shiyan , Li Yanting , Yuan Wenzhen 
Published: July 2022

PurposeThis research investigated the predictive role of metabolic syndrome (MetS) in breast cancer neoadjuvant chemotherapy (BCNACT) response.MethodsOne hundred fifty primary breast cancer (BC) patients who underwent neoadjuvant chemotherapy (NACT) were included retrospectively. MetS, MetS components [waist circumference (WC), fasting blood glucose (FBG), blood pressure, triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C)], serum lipid, and other MetS-related laboratory indicators within two weeks before BCNACT were evaluated. Univariate, multivariate, and subgroup analyses were performed to determine the predictors of BCNACT pathologic complete response (pCR), clinical response, and pathologic response. The effectiveness of the model was evaluated via receiver operating characteristic curve (ROC) and calibration curve. External validation was performed through 135 patients.ResultsUnivariate analysis revealed that MetS before BCNACT predicted poor BCNACT response (pCR, P = 0.003; clinical response, P = 0.033; pathologic response, P &lt; 0.001). Multivariate analysis confirmed that MetS before BCNACT predicted lower pCR rate (P = 0.041). Subgroup analysis showed that this relationship was significant in estrogen receptor (ER) (−) (RR = 0.266; 95% CI, 0.074–0.954), human epidermal growth factor 2 (HER2) (−) (RR = 0.833; 95% CI, 0.740–0.939) and TNBC (RR = 0.833; 95% CI, 0.636–0.995). Multivariate analysis of external validation confirmed that pretreatment MetS was associated with a lower pCR rate (P = 0.003), and subgroup analysis also confirmed that this relationship had significant statistical differences in ER (−), HER2 (−), and TNBC subgroups.ConclusionsMetS before BCNACT predicted a lower pCR rate. Intervention on MetS status, especially in ER (−), HER2 (−), and TNBC subgroups, is expected to improve the response rate of BCNACT further.
Role of Surgery in the Management of Liver Metastases From Gastrointestinal Stromal Tumors
Authors: Xue Anwei , Gao Xiaodong , He Yifeng , Shu Ping , Huang Xiaowu , Sun Jianyi , Lu Jiangshen , Hou Yingyong , Fang Yong , Shen Kuntang 
Published: July 2022

BackgroundThe clinical benefit of hepatectomy in patients with liver metastases from gastrointestinal stromal tumors (GIST) has not been well defined in this era of tyrosine kinase inhibitor (TKI). Our study aims to demonstrate the survival advantage of adding hepatectomy in patients with GIST liver metastases.MethodsInformation on patients with metastatic GIST treated or consulted between January 2006 and December 2018 was retrieved. Patients without extrahepatic metastases were included and classified into the surgical (S group) and non-surgical (NS group). Clinicopathological features were compared and their association with survival was assessed.ResultsA total of 119 patients were included in this retrospective analysis, 62 in the S group and 59 in the NS group. Comparison of clinicopathological features showed that a markedly higher proportion of patients in the S group had ≤3 hepatic lesions (79.0% vs. 29.8%, p&lt;0.001). After a median follow-up duration of 56 months, patients in the S group had significantly better progression-free survival (PFS) and marginally improved overall survival (OS) than those in the NS group (3y PFS:86.2% vs. 64.6%, p=0.002; 5y OS: 91.5% vs. 78.3%, p=0.083). After propensity score matching, multivariate analysis identified hepatectomy as the only significant prognostic factor for PFS while age, hepatectomy and max tumor diameter were significant predictor for OS.ConclusionsAddition of hepatectomy provided longer disease control in patients with metastatic GIST confined to the liver. Upfront hepatectomy followed by imatinib therapy is worthwhile trying in patients with single and easily removable lesions.
The Perceived Impact of COVID-19 on the Mental Health Status of Adolescent and Young Adult Survivors of Childhood Cancer and the Development of a Knowledge Translation Tool to Support Their Information Needs
Authors: Hou Sharon H. J. , Tran Andrew , Cho Sara , Forbes Caitlin , Forster Victoria J. , Stokoe Mehak , Allapitan Elleine , Wakefield Claire E. , Wiener Lori , Heathcote Lauren C. , Michel Gisela , Patterson Pandora , Reynolds Kathleen , Schulte Fiona S. M. 
Published: July 2022

BackgroundAdolescent and young adult (AYA; 13 to 39 years) survivors of childhood cancer may be especially vulnerable to physical health and mental health concerns during the pandemic. We investigated the impact of COVID-19 on the mental health status of AYA survivors (Aim 1) and shared tailored, evidence-based health-related information on COVID-19 (Aim 2).MethodsBetween May and June 2020, participants completed a cross-sectional online survey assessing their cancer history, current mental health status, and their COVID-19 information needs.ResultsNinety-four participants (78 females, 13 males, 2 non-binary) with a mean age of 26.9 years (SD = 6.2) were included in the final sample. Participants reported residing from 10 countries and 94% identified as White. Nearly half of the participants (49%) described their mental health status as worse now than before the pandemic. Thirty-nine participants (41%) that indicated their current mental health status was tied to fears/worries about their past cancer and treatment experienced a higher level of anxiety and PTSS than those who did not report the same. Most participants (77%) had not received any information related to the potential risks of COVID-19 and expressed an interest in receiving this information. In response, an infographic detailing recommended strategies for coping with mental health problems in the pandemic, along with preliminary study findings, was developed.DiscussionAYA survivors reporting their mental health status was linked to their past cancer experienced poorer mental health. There is a value to educating survivors on their potential health risks, but accounting for their perceived mental health vulnerabilities should be considered when disseminating knowledge. The use of an infographic is a unique contribution towards the development of innovative and personalized means of sharing health education to this vulnerable yet resilient group. This research on the mental health status of AYA survivors very early in the pandemic informs continued initiatives investigating the rapidly changing nature of how COVID-19 may impact AYA survivors today and in the future.
Neuromodulation Treatments of Pathological Anxiety in Anxiety Disorders, Stressor-Related Disorders, and Major Depressive Disorder: A Dimensional Systematic Review and Meta-Analysis
Authors: Gay Florian , Singier Allison , Aouizerate Bruno , Salvo Francesco , Bienvenu Thomas C. M. 
Published: July 2022

BackgroundPathological anxiety is responsible for major functional impairments and resistance to conventional treatments in anxiety disorders (ADs), posttraumatic stress disorder (PTSD) and major depressive disorder (MDD). Focal neuromodulation therapies such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS) and deep brain stimulation (DBS) are being developed to treat those disorders.MethodsWe performed a dimensional systematic review and meta-analysis to assess the evidence of the efficacy of TMS, tDCS and DBS in reducing anxiety symptoms across ADs, PTSD and MDD. Reports were identified through systematic searches in PubMed/Medline, Scopus and Cochrane library (inception to November 2020), followed by review according to the PRISMA guidelines. Controlled clinical trials examining the effectiveness of brain stimulation techniques on generic anxiety symptoms in patients with ADs, PTSD or MDD were selected.ResultsNineteen studies (RCTs) met inclusion criteria, which included 589 participants. Overall, focal brain activity modulation interventions were associated with greater reduction of anxiety levels than controls [SMD: −0.56 (95% CI, −0.93 to−0.20, I2 = 77%]. Subgroup analyses revealed positive effects for TMS across disorders, and of focal neuromodulation in generalized anxiety disorder and PTSD. Rates of clinical responses and remission were higher in the active conditions. However, the risk of bias was high in most studies.ConclusionsThere is moderate quality evidence for the efficacy of neuromodulation in treating pathological anxiety.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=233084, identifier: PROSPERO CRD42021233084. It was submitted on January 29th, 2021, and registered on March 1st, 2021. No amendment was made to the recorded protocol. A change was applied for the subgroup analyses based on target brain regions, we added the putative nature (excitatory/inhibitory) of brain activity modulation.
Are Measurement Instruments Responsive to Assess Acute Responses to Load in High-Level Youth Soccer Players?
Authors: Ruf Ludwig , Drust Barry , Ehmann Paul , Skorski Sabrina , Meyer Tim 
Published: July 2022

PurposeThe aim of this study was to assess the short-term responsiveness of measurement instruments aiming at quantifying the acute psycho-physiological response to load in high-level adolescent soccer players.MethodsData were collected from 16 high-level male youth soccer players from the Under 15 age group. Players were assessed on two occasions during the week: after 2 days of load accumulation (“high load”) and after at least 48 h of rest. Measurements consisted of the Short Recovery and Stress Scale (SRSS), a countermovement jump (CMJ) and a sub-maximal run to assess exercise heart-rate (HRex) and heart-rate recovery (HRR60s). Training load was quantified using total distance and high-speed running distance to express external and sRPE training load to express internal load. It was expected that good instruments can distinguish reliably between high load and rest.ResultsOdd ratios (0.74–1.73) of rating one unit higher or lower were very low for athlete-reported ratings of stress and recovery of the SRSS. Standardized mean high load vs. rest differences for CMJ parameters were trivial to small (−0.31 to 0.34). The degree of evidence against the null hypothesis that changes are interchangeable ranged from p = 0.04 to p = 0.83. Moderate changes were observed for HRex (−0.62; 90% Cl −0.78 to −0.47; p = 3.24 × 10−9), while small changes were evident for HRR60s (0.45; 90% Cl 0.08–0.80; p = 0.04). Only small to moderate repeated-measures correlations were found between the accumulation of load and acute responses across all measurement instruments. The strongest relationships were observed between HRex and total distance (rm-r = −0.48; 90% Cl −0.76 to −0.25).ConclusionResults suggest that most of the investigated measurement instruments to assess acute psycho-physiological responses in adolescent soccer players have limited short-term responsiveness. This questions their potential usefulness to detect meaningful changes and manage subsequent training load and program adequate recovery.
Systematic Literature Review of Hearing Preservation Rates in Cochlear Implantation Associated With Medium- and Longer-Length Flexible Lateral Wall Electrode Arrays
Authors: Van de Heyning Paul H , Dazert Stefan , Gavilan Javier , Lassaletta Luis , Lorens Artur , Rajan Gunesh P , Skarzynski Henryk , Skarzynski Piotr H , Tavora-Vieira Dayse , Topsakal Vedat , Usami Shin-ichi , Van Rompaey Vincent , Weiss Nora M , Polak Marek 
Published: July 2022

BackgroundThe last two decades have demonstrated that preoperative functional acoustic hearing (residual hearing) can be preserved during cochlear implant (CI) surgery. However, the relationship between the electrode array length and postoperative hearing preservation (HP) with lateral wall flexible electrode variants is still under debate.Aims/ObjectivesThis is a systematic literature review that aims to analyze the HP rates of patients with residual hearing for medium-length and longer-length lateral wall electrodes.MethodA systematic literature review methodology was applied following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) recommendations to evaluate the HP rates of medium-length and longer-length lateral wall electrodes from one CI manufacturer (medium length FLEX 24, longer length FLEX 28 and FLEX SOFT, MED-EL, Innsbruck, Austria). A search using search engine PubMed (https://www.ncbi.nlm.nih.gov/pubmed/) was performed using the search terms “hearing preservation” or “residual hearing” and “cochlear implant” in “All fields.” Articles published only in English between January 01, 2009 and December 31, 2020 were included in the search.ResultsThe HP rate was similar between medium-length (93.4%–93.5%) and longer (92.1%–86.8%) electrodes at 4 months (p = 0.689) and 12 months (p = 0.219). In the medium-length electrode group, patients under the age of 45 years had better HP than patients above the age of 45 years.ConclusionsBoth medium-length and longer electrode arrays showed high hearing preservation rates. Considering the hearing deterioration over time, implanting a longer electrode at primary surgery should be considered, thus preventing the need for future reimplantation.
Evaluating Landsat-8 and Sentinel-2 Data Consistency for High Spatiotemporal Inland and Coastal Water Quality Monitoring
Authors: Hafeez Sidrah , Wong Man Sing , Abbas Sawaid , Asim Muhammad 
Published: July 2022

The synergy of fine-to-moderate-resolutin (i.e., 10–60 m) satellite data of the Landsat-8 Operational Land Imager (OLI) and the Sentinel-2 Multispectral Instrument (MSI) provides a possibility to monitor the dynamics of sensitive aquatic systems. However, it is imperative to assess the spectral consistency of both sensors before developing new algorithms for their combined use. This study evaluates spectral consistency between OLI and MSI-A/B, mainly in terms of the top-of-atmosphere reflectance (ρt), Rayleigh-corrected reflectance (ρrc), and remote-sensing reflectance (Rrs). To check the spectral consistency under various atmospheric and aquatic conditions, near-simultaneous same-day overpass images of OLI and MSI-A/B were selected over diverse coastal and inland areas across Mainland China and Hong Kong. The results showed that spectral data obtained from OLI and MSI-A/B were consistent. The difference in the mean absolute percentage error (MAPE) of the OLI and MSI-A products was ~8% in ρt and ~10% in both ρrc and Rrs for all the matching bands, whereas the MAPE for OLI and MSI-B was ~3.7% in ρt, ~5.7% in ρrc, and ~7.5% in Rrs for all visible bands except the ultra-blue band. Overall, the green band was the most consistent, with the lowest MAPE of ≤ 4.6% in all the products. The linear regression model suggested that product difference decreased significantly after band adjustment with the highest reduction rate in Rrs (NIR band) and Rrs (red band) for the OLI–MSI-A and OLI–MSI-B comparison, respectively. Further, this study discussed the combined use of OLI and MSI-A/B data for (i) time series of the total suspended solid concentrations (TSS) over coastal and inland waters; (ii) floating algae area comparison; and (iii) tracking changes in coastal floating algae (FA). Time series analysis of the TSS showed that seasonal variation was well-captured by the combined use of sensors. The analysis of the floating algae bloom area revealed that the algae area was consistent, however, the difference increases as the time difference between the same-day overpasses increases. Furthermore, tracking changes in coastal FA over two months showed that thin algal slicks (width < 500 m) can be detected with an adequate spatial resolution of the OLI and the MSI.
Pandangan Hospitalitas Kristen Terhadap Korban Bencana Alam
Authors: Patendeng Julian Eliezer 
Published: July 2022

The author through this paper, describes the Christian Hospitality’s view of the victims of natural disasters. It is a behavior that manifests a spirit of family and friendship, so that it is one’s responsibility toward another, as it is an interaction of friendship. Using the quantitative approach of literature of library study with data collection directed to the search of documents and information through books, journals, articles and websites, and apply descriptive methods of interpretative that produce three main points: First, the plurality of societies the experience natural disaster; Second, in the plurality of these disaster victims, Christian hospitality goes to victims of natural disasters; Third, this hospitality can be realized in love for everyone without looking at their identity, “love” can be realized in the service of deacon, prayer and pastoral or psychic mentoring of victims of natural disasters.