bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supplier interfaces in digital transformation: an exploratory case study of a manufacturing firm and IoT suppliers
Authors: Ferreira Carla Cleri , Lind Frida 
Published: July 2022

Purpose
The purpose of this paper is to characterize the interfaces between manufacturing companies and the Internet of Things (IoT) suppliers involved in their digital servitization.

Design/methodology/approach
This paper builds on an explorative case study of a manufacturing firm and its IoT suppliers. This paper relies on the Industrial Network Approach to study interfaces between buying firms and their suppliers.

Findings
This paper identifies three distinct types of supplier interfaces: connected, digital and digital-physical. They all contain technical resource interfaces with additional organizational and/or technical complexities that need to be managed. Connectivity, an Agile approach to software development and strong technical dependence emerged as key factors that impact the interactions between manufacturing firms and IoT suppliers and how their resources are combined.

Practical implications
This paper offers managerial implications regarding the importance of internal organization (such as appropriate cross-functional teams) to manage the dynamics of collaborations required by digital technologies, maintain interactions with IoT suppliers and identify and manage interdependences between IoT suppliers. Building close relationships with suppliers of crucial infrastructure (e.g. IoT cloud platform and data security systems) can also be beneficial for manufacturing firms to reduce risks. Finally, attention should be given to IoT technology strategy, which impacts both digital and digital-physical supplier interfaces.

Originality/value
In digital servitization, manufacturing firms are heavily reliant on external resources for IoT technology. Despite this, few studies have investigated the characteristics of their interfaces with IoT suppliers, how these can be managed and how resources are combined.
Keeping time: a taxonomy of temporal effects on employees at the workplace
Authors: Das Roshni 
Published: July 2022

Purpose
In recent years, there has been a burgeoning interest around “time” or “temporality” as a subject of study in workplace behavior at the microlevel. This research is, however, not integrated systematically till date. The purpose of this study is to address this gap with a comprehensive review of this domain.

Design/methodology/approach
The present study conducts a large-scale bibliometric analysis of 1,120 papers, collected from Scopus, to decipher the structural patterns underlying this research domain.

Findings
The analysis unraveled the performance statistics (articles, journals, authors) and intellectual structure (themes, keywords, ontological position) of temporal research. The authors also present a matrix of extant and emergent thought in time studies and discuss how they fare on causality versus dynamicity dimensions.

Research limitations/implications
Future research directions are discussed extensively based on qualitative and quantitative insights.

Originality/value
This is a structured literature review combined with bibliometric analysis of a large corpus of research.
Modelling the factors in implementation of environmental sustainability in healthcare organisations
Authors: Vaishnavi V. , Suresh M. 
Published: July 2022

PurposeEnvironmental sustainability (ES) is an increasing tendency in the healthcare industry as it seeks to enhance the environmental friendliness and reduces waste in operations to save money. The objective of research article is to identify the factors that contribute to improving the performance of ES in hospitals. Understanding the factors that contribute to the improvement of healthcare services may be helpful for practitioners, who need to address and implement an effective framework to enable an environment-friendly practice in hospitals.Design/methodology/approachThe current study utilised the technique called total interpretive structural modelling (TISM) to identify the factors and understand the interconnection between the identified factors. A literature review revealed 12 factors, which were then refined with the input of hospital experts. Based on a questionnaire survey, a planned interview is conducted in chosen Indian hospitals. The matrix impact cross multiplication applied to classification (MICMAC) study employs dependency and driving power to identify the hierarchical relationship between the detected factors.FindingsGreen building initiatives, water consumption, resource usage, and renewable energy were identified as key factors in the study. Other factors such as staff behaviour, procurement of goods and management of hazardous substance would be influenced by these fundamental components. With the implementation of green initiatives in the hospital, ES is primarily used to reduce the excessive use of scarce resources.Practical implicationsThe ES programme begins at the hospital grounds, with awareness and specific training provided to all personnel, including doctors, nurses, and managers at all levels. The training programme is intended to raise awareness; sessions are divided into targeted groups; a new organisational structure is created; and a consultant agent is hired to commence ES.Originality/valueExisting literature has focussed mostly on ES factors such as carbon emissions, water conservation, and effective waste disposal, while ignoring organisational viewpoints and their interrelationships. As a result, the current study used TISM to show the relationship between various organisational and environmental perspective components in order to comprehend the reasoning behind improving performance.
The impact of COVID-19 on people with intellectual disabilities
Authors: Warner Katie , Marrington Cathryn 
Published: July 2022

PurposeAs Clinical Psychologists working in a tertiary Intellectual Disability (ID) service in the UK, this paper aims to address the impact of Covid-19 – and the subsequent transition out of Covid-19 restrictions – on individuals with an ID, and the clinicians working alongside them. Additionally, the paper reflects upon how Covid-19 has shaped and manipulated therapeutic communities and environments.Design/methodology/approachThis paper is reflective in nature and reviews current evidence associated with how people with an ID experienced the impact of Covid-19. Clinicians reflect upon their shared experience in line with this evidence.FindingsThis paper highlights perpetuating inequalities and injustices on people with an ID as a result of Covid-19. Further, it is indicated that that there should be consideration of how people with an intellectual disability experience transitions back to their day-to-day environments and encourages clinicians to widely consider how to shape therapeutic communities and environments.Originality/valueMultiple themes have been addressed in this paper, and the reflections add to an understanding of how those individuals specifically working in, or using intellectual disability services, have experienced the Covid-19 pandemic, though a critical lens.
Human DNA contamination of postmortem examination facilities: Impact of COVID‐19 cleaning procedure
Authors: Bini Carla , Giorgetti Arianna , Giovannini Elena , Pelletti Guido , Fais Paolo , Pelotti Susi 
Published: July 2022

AbstractThe DNA contamination of evidentiary trace samples, included those collected in the autopsy room, has significant detrimental consequences for forensic genetics investigation. After the COVID‐19 pandemic, methods to prevent environmental contamination in the autopsy room have been developed and intensified. This study aimed to evaluate the level of human DNA contamination of a postmortem examination facility before and after the introduction of COVID‐19‐related disinfection and cleaning procedures. Ninety‐one swabs were collected from the surfaces and the dissecting instruments, analyzed by real‐time quantitative PCR (q‐PCR) and typed for 21 autosomal STRs. Sixty‐seven out of 91 samples resulted in quantifiable human DNA, ranging from 1 pg/μl to 12.4 ng/μl, including all the samples collected before the implementation of COVID‐19 cleaning procedures (n = 38) and 29 out of 53 (54.7%) samples taken afterward. All samples containing human DNA were amplified, resulting in mixed (83.6%), single (13.4%), and incomplete (3%) profiles. A statistically significant decrease in DNA contamination was found for dissecting instruments after treatment with chlorhexidine and autoclave (p < 0.05). Environmental decontamination strategies adopted during COVID‐19 pandemic only partially solved the long‐standing issue of DNA contamination of postmortem examination facilities. The pandemic represents an opportunity to further stress the need for standardized evidence‐based protocols targeted to overcome the problem of DNA contamination in the autopsy room.
Conservation biological control of the fruit fly parasitoid Fopiusa arisanus (Hymenoptera: Braconidae)
Authors: Harris Colin , Bromley Emma , Clarke Linda K , Kay Bianca J , Schwenke Andrew C , Clarke Anthony R 
Published: July 2022

AbstractFopius arisanus is a parasitoid of Bactrocera fruit flies. In sub‐tropical Australia, it can cause >30% parasitism of Queensland fruit fly, Bactrocera tryoni. There has been minimal research effort globally, and none in Australia, to determine how the abundance of this species can be maintained and increased through conservation biological control. We carried out three research activities aimed at conserving this species in a landscape: (i) testing mesh sizes for augmentoria, devices into which fallen fruit can be placed that capture emergent flies while allowing parasitoid release; (ii) investigation of the suitability of wild tobacco, Solanum mauritianum, and wild tobacco fly, Bactrocera cacuminata, as a non‐crop refuge for the parasitoid; and (iii) the value of floral resources for companion planting to increase carbohydrate sources. We determined that a mesh size of approximately 2 mm2 retained near 100% of fruit flies while releasing ~90% of parasitoids. A readily obtainable 50% shade cloth maintained a mesh pore of this size and was confirmed as suitable for making augmentoria. In South East Queensland, the wild tobacco/wild tobacco fly system was demonstrated to host F. arisanus continuously through the year, with an annual parasitism rate of 31%, peaking in the spring at 60%. A second fruit fly parasitoid, Diachasmimorpha kraussii, was also collected from this system, but at lower levels. Fopius arisanus were able to move >120 m from a wild tobacco patch to parasitise fruit fly‐infested fruit. None of five floral resources trialled increased wasp longevity beyond the mean of 5.3 days achieved by a water‐only control. When five additional fruit juice/fruit pulp resources were tested, only one increased wasp longevity, by 1.3 days, over the water‐only control. In contrast, wasps fed on honey and water survived for a mean of nearly 40 days. We thus concluded that in the field F. arisanus does not gain its nutritional needs from either flowers or fruit. Augmentoria offer an easily scalable tool, suitable for backyard growers through to commercial producers, which provides the control benefits of crop hygiene while not disrupting the parasitoid cycle. Where wild tobacco can be maintained without impacting the quality of farm habitat, it has great potential as a year‐round reservoir of the wasp. Companion planting to increase nectar resources is not recommended for F. arisanus conservation biological control.
Perception of Somali pastoralists in Adadle woreda, Eastern Ethiopia, towards wildlife at the human‐animal interface, conservation and wildlife population change
Authors: Ibrahim Mohammed , Muhummed Abdifatah , Melaku Hamere , Mohammed Seid , Zinsstag Jakob , Tschopp Rea 
Published: July 2022

AbstractPastoralists and wildlife co‐exist in the Somali Regional State competing for habitat, food and water resources. A questionnaire survey conducted among 198 pastoralists, captured information on their perception of wildlife against the backdrop of wildlife population decrease, illegal wildlife trade and lack of quantitative and qualitative data in the area. The top perceived threats to livestock were drought (46%), wildlife attacks (33.8%) and diseases (20.2%). Daily encounters between wildlife and livestock were reported by 61.1% of respondents. Herbivores, including warthogs, accounted for the majority of these encounters (88.4%), whereas carnivores were rarely observed with livestock, except for jackals. The majority (92.9%) of the respondents did not think that wildlife could transmit diseases to livestock. Jackals were reported by 7.1% to transmit rabies. A strong dislike for wildlife was recorded in 99% of all respondents. All stated that wildlife should not be protected. Half of the respondents did not see any benefits in wildlife. Wildlife populations have decreased over the last 10 years, particularly lions and cheetahs. Pastoralist's attitudes and perceptions towards wildlife in the study area were negative, potentially affecting conservation efforts. There is an urgent need to improve awareness of the benefits of wildlife and to include wildlife in integrated human‐livestock‐environment surveillance systems.
Tilmanocept as a novel tracer for lymphatic mapping and sentinel lymph node biopsy in melanoma and oral cancer
Authors: Mwagiru Derek , Shivashankar Pranav , Wong Eva , Farlow David , Cambden Brad , Abdul‐Razak Muzib 
Published: July 2022

AbstractBackgroundSentinel lymph node biopsy (SLNB) has been pivotal for pathological assessment of nodal status in cutaneous melanoma (CM) and oral cavity squamous cell carcinoma (OCSCC) thus crucial for staging. An ideal agent for lymphatic mapping should have a standardized preparation, appropriate accumulation in first‐echelon nodes and no side effects. Tilmanocept, a CD206‐receptor targeted novel radiotracer fulfils these properties. This study investigated Tilmanocept for lymphoscintigraphy and intraoperative identification of sentinel lymph nodes (SLN) in CM and OCSCC.MethodsThis prospective cross sectional study examined patients who presented to Crown Princess Mary Cancer Centre, Westmead Hospital, Sydney. Patients had biopsy proven tumours with clinically and radiologically negative regional lymph nodes. Tilmanocept guided lymphoscintigraphy was followed by intraoperative SLNs identification via handheld gamma probe. Primary endpoints were detection and retrieval rate of SLNs while secondary endpoints included pathological status of SLNs.ResultsThirty‐five patients were included (26 with CM and 9 with OCSCC) with the most common primary tumour site for CM on the extremities (33.3%). Lymphoscintigraphy with Tilmanocept identified at least 1 SLN (sensitivity 100%) in all patients. SLNs were retrieved in all of patients intraoperatively (100% retrieval rate) with positive nodes found in 20% of patients. Tilmanocept also demonstrated 100% tissue specificity, with lymph nodal tissue confirmed histologically, with no false positives.ConclusionTilmanocept is a reliable radiotracer for assessing the nodal status in patients with CM and OCSCC. Our group is the first to evaluate the use of Tilmanocept in the Australian setting, adding to the limited studies worldwide.
Women's interest in surgery as a career in the early postgraduate period: a national longitudinal study
Authors: Meyer Juliette A. , Connell Charlotte J. W. , Rennie Sarah , Verstappen Antonia C. , Poole Phillippa J. 
Published: July 2022

AbstractBackgroundWomen remain underrepresented in Surgery in Aotearoa New Zealand (AoNZ). This study described interest in surgical careers by gender in the early postgraduate period and associated influencing factors.MethodsAoNZ medical graduates between 2012 and 2016 responding to an Exit Questionnaire (EQ) at graduation and 3 years later (PGY3) as part of the Medical Schools Outcomes Database and Longitudinal Tracking Project (MSOD) were included. Analyses of specialty preferences and influences by gender were performed.ResultsOf 992 participants, 58% were women. At EQ, 158 participants (16%) had a surgical preference: 21% of men and 14% of women (P < 0.01). By PGY3, this was 20% of men and 10% of women (P < 0.01). A logistic regression found women were half as likely as men to have a surgical preference at PGY3. Those with a surgical preference at EQ were over 23 times more likely to have a surgical preference at PGY3, irrespective of gender. There were significant differences in self‐reported career influencing factors between women and men at EQ and PGY3, as well as between PGY3 women with a surgical and those with a non‐surgical preference. These included nature of the specialty, training requirements, lifestyle, family and personal factors.ConclusionsIncreasing the proportion of women in Surgery requires a multifaceted approach starting during medical school and continuing through early postgraduate years. More needs to be done to make surgical experiences as an undergraduate and junior doctor appealing to women.
Population pharmacokinetic modelling of febuxostat in healthy subjects and people with gout
Authors: Kamel Bishoy , Abuhelwa Ahmad Y. , Foster David , Duong Janna K. , Graham Garry G. , Williams Kenneth M. , Pile Kevin D. , Day Richard O. 
Published: July 2022

AimsTo investigate and characterise the pharmacokinetics of febuxostat and the effect of the covariates of renal function and body size descriptors on the pharmacokinetics of the drug.MethodsBlood samples (n = 239) were collected using sparse and rich sampling strategies from healthy (n = 9) and gouty (n = 29) subjects. Febuxostat plasma concentrations were measured by a validated high‐performance liquid chromatography method. Population pharmacokinetic analysis was performed using NONMEM. A common variability on bioavailability (FVAR) approach was used to test the effect of fed status on absorption parameters. Covariates were modelled using a power model.ResultsThe time course of the plasma concentrations of febuxostat is best described by a two‐compartment model. In the final model, the population mean for apparent clearance (CL/F), apparent central volume of distribution (Vc/F), apparent peripheral volume of distribution (Vp/F), absorption rate constant (ka) and apparent intercompartmental clearance (Q/F) were 6.91 l h−1, 32.8 l, 19.4 l, 3.6 h−1 and 1.25 l h−1, respectively. The population parmater variability (coefficient of variation) for CL/F, Vc/F and Vp/F were 13.6, 22 and 19.5%, respectively. Food reduced the relative biovailability and ka by 67% and 87%, respectively. Renal function, as assessed by creatinine clearance, was a significant covariate for CL/F while body mass index was a significant covariate for Vc/F.ConclusionsRenal function and body mass index were significant covariates. Further work is warranted to investigate the clinical relevance of these results, notably as renal impairment and obesity are common occurrences in people with gout.
Making informed choices about cannabis use during pregnancy and lactation: A qualitative study of information use
Authors: Taneja Shipra , Panday Janelle , Popoola Anuoluwa , Greyson Devon , McDonald Sarah D. , Patel Tejal , Vanstone Meredith 
Published: July 2022

AbstractBackgroundCannabis use during pregnancy and lactation continues to increase as some perceive cannabis to be helpful for symptom management and coping. As such, pregnant and lactating people are faced with challenging decisions, weighing benefits against the potential risks of cannabis use. To help clinicians facilitate informed choices, we explored the self‐identified information needs of pregnant and lactating people who are deciding whether or not to use cannabis. We aimed to describe the modes and sources of their information‐seeking and their satisfaction with the information they found.MethodsWe interviewed 52 people in Canada who made the decision to start, stop, or continue using cannabis during pregnancy and lactation. Participants were recruited from advertisements in prenatal clinics and on social media. We utilized an inductive approach to analysis focused on information used in decision‐making about cannabis use, including the process of seeking and evaluating that information.ResultsParticipants were deliberate in their search for information, most commonly seeking information on risks of use. Information sources were mainly online material or people in their social networks. Clinicians were not commonly described as a knowledgeable or supportive source of information. Overwhelmingly, participants described the information they found as insufficient and emphasized the need for more comprehensive and trustworthy sources of information.ConclusionsParticipants identified distinct and unmet information needs associated with their decision to use cannabis. They described a desire for clear evidence about the impact of cannabis use, including information about how to balance the benefits they perceived from cannabis use with the risks of harm.
Polarity switching of ovarian cancer cell clusters via SRC family kinase is involved in the peritoneal dissemination
Authors: Kawata Mayuko , Kondo Jumpei , Onuma Kunishige , Ito Yu , Yokoi Takeshi , Hamanishi Junzo , Mandai Masaki , Kimura Tadashi , Inoue Masahiro 
Published: July 2022

AbstractPeritoneal dissemination is a predominant pattern of metastasis in patients with advanced ovarian cancer. Despite recent progress in the management strategy, peritoneal dissemination remains a determinant of poor ovarian cancer prognosis. Using various histological types of patient‐derived ovarian cancer organoids, the roles of the apicobasal polarity of ovarian cancer cell clusters in peritoneal dissemination were studied. First, it was found that both ovarian cancer tissues and ovarian organoids showed apicobasal polarity, where zonula occludens‐1 (ZO‐1) and integrin beta 4 (ITGB4) served as markers for apical and basal sides, respectively. The organoids in suspension culture, as a model of cancer cell cluster floating in ascites, showed apical‐out/basal‐in polarity status, while once embedded in extracellular matrix (ECM), the organoids switched their polarity to apical‐in/basal‐out. This polarity switch was accompanied by the SRC kinase family (SFK) phosphorylation and was inhibited by SFK inhibitors. SFK inhibitors abrogated the adherence of the organoids onto the ECM‐coated plastic surface. When the organoids were seeded on a mesothelial cell layer, they cleared and invaded mesothelial cells. In vivo, dasatinib, an SFK inhibitor, suppressed peritoneal dissemination of ovarian cancer organoids in immunodeficient mice. These results suggest SFK‐mediated polarity switching is involved in peritoneal metastasis. Polarity switching would be a potential therapeutic target for suppressing peritoneal dissemination in ovarian cancer.