bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS ETNOSAINS TRADISI RANTAU LARANGAN KAMPUNG TANDIKAT SEBAGAI SUMBER BELAJAR BIOLOGI
Authors: Rikizaputra Rikizaputra , Lufri Lufri , Syamsurizal Syamsurizal , Arsih Fitri , Elvianasti Mega 
Published: April 2022

Keberadaan lingungan sekitar merupakan sumber belajar yang tidak bisa dipisahkan dari pembelajaran IPA khususnya Biologi. Tardisi rantau larangan Tandikat merupakan wujud kearifan masyarakat setempat mengelola keseimbangan lingkungan. Penelitian ini bertujuan untuk mendeskripsikan dan merekonstruksi pengetahuan ilmiah (scientific knowledge) dar tradisi rantau larangan. Pengumpulan data dilakukan melalui observasi dan wawancara. Sumber data yang digunakan yakni tokoh masyarakat, tokoh adat dan masyarakat setempat yang dipilih secara purposive. Data dianalisis melalui tahapan reduksi data, penyajian data, penarikan kesimpulan dan verifikasi. Hasil penelitian menunjukkan bahwa tradisi rantau larangan masyarakat merupakan bagian dalam sistem pengelolaan sumber daya perairan sungai di kampung Tandikat. Adanya larangan kepada masyarakat untuk tidak menagmbil ikan dan biota sungai lainnya pada rentang waktu tertentu atau 1 tahun. Dilarang menebang pohon pohon besar yang tumbuh di bantaran sungai. Dilarang menyentrum dan meracun ikan pada saat membuka larangan. Penerapan aturan ini memiliki nilai konservasi lingkungan untuk menjaga keseimbangan ekosistem sungai. Terdapat potensi sumber belajar IPA Biologi pada tradisi rantau larangan, yaitu pada konsep pelestarian ekosistem dan pencemaran lingkungan.
PENGARUH PERENCANAAN DAN IMPLEMENTASI TERHADAP REALISASI ANGGARAN DENGAN KEBIJAKAN PERUBAHAN ANGGARAN SEBAGAI VARIABEL INTERVENING PADA DINAS KESEHATAN KOTA KUPANG
Authors: Mbado Margarethy Rohanie , Mbate Maromi Merlin 
Published: April 2022

The Kupang City Health Office is an accounting entity from the Kupang City Government which is obliged to carry out accounting and accountability reports for the implementation of the Regional Revenue and Expenditure Budget by compiling financial reports in the form of Budget Realization Reports (LRA), Balance Sheets, and Notes to Financial Statements abbreviated as CALK. This type of research is quantitative using the SEM-PLS analysis tool. The informants in this study were employees who work in the Health Department of Kupang City.
The results showed that The results of the descriptive analysis of all the variables in this research were in the good category, so that the management of the Health Department needed to maintain the system that was already running and they needed to improve their work performance so that in the future it could be even better, Planning variable significantly influence with the budget policies variable of the Health Department of Kupang City, The planning variable does not significantly influence the budget realization variable, The implementation variable has a significant influence with the budget policies variable, The implementation variable does not significantly influence the budget realization variable, Budget policies variable significantly influence budget realization variable, Budget planning variable indirectly through budget policies has a significant influence on budget realization, Budget implementation variable indirectly through the budget policies significantly influence the budget realization.
Based on the results of this research, it is suggested that in running the plan, the Health Department of Kupang City should use achievement data as the estimate and the budget in planning needs to be increased, in the budget implementation of Health Department of Kupang City it is important to pay attention about coordination in the inclusion of APBD draft documents so that budget discipline can run properly, related to the budget realization of the Health Department of Kupang City, it should pay more attention to activities that involve many people
In Vivo Evaluation of Cefuroxime Axetil-Loaded Bioadhesive Nanoparticles to Treat Haemophilus influenzae-Induced Otitis Media
Authors: Lin Hong , Jia Yizhen , Kong Xiaohan , Wang Shiting , Liu Xiangyou , Liu Yang , Deng Yang 
Published: April 2022

Otitis media (OM) is a common disease in children. One of the most common pathogens causing OM is non-typeable Haemophilus influenzae (NTHi). NTHi in the middle ear can be successfully eradicated by a regimen of oral antibiotics sustained for 7–10 days (e.g., cefuroxime axetil 250 mg/day for patients aged 3 months to 2 years and 500 mg/day for patients ages ≥2 years). However, lack of compliance is relevant to treatment failure or early relapse. In order to overcome these challenges, we have developed antibiotics-loaded bioadhesive nanoparticles (BNPs) that can adhere to the epidermis of the middle ear after local administration and significantly prolong the release time of antibiotics in the middle ear. Compared with oral administration of CA, local delivery of free antibiotic cefuroxime axetil (CA), and CA loaded non-bioadhesive nanoparticles (CA/NNPs), BNPs loaded with cefuroxime axetil (CA/BNPs) showed significantly longer retention time in the middle ear, resulting in continuous release of the drug and higher therapeutic efficacy against OM with only a single dosage. CA concentrations were maintained above the minimum inhibitory concentration (MIC) for NTHi throughout 7 days’ treatment. NTHi OM in a mouse model was successfully eradicated without causing tissue toxicity. CA/BNPs minimize systemic drug exposure through local administration, as demonstrated by undetectable levels in the blood.
Zero Fluoroscopy Arrhythmias Catheter Ablation: A Trend Toward More Frequent Practice in a High-Volume Center
Authors: Troisi Federica , Guida Pietro , Quadrini Federico , Di Monaco Antonio , Vitulano Nicola , Caruso Rosa , Orfino Rocco , Cecere Giacomo , Anselmino Matteo , Grimaldi Massimo 
Published: April 2022

BackgroundAwareness of radiation exposure risks associated to interventional cardiology procedures is growing. The availability of new technologies in electrophysiology laboratories has reduced fluoroscopy usage during arrhythmias ablations. The aim of this study was to describe procedures with and without X-Rays and to assess feasibility, safety, and short-term efficacy of zero fluoroscopy intervention in a high-volume center oriented to keep exposure to ionizing radiation as low as reasonably achievable.MethodsCardiac catheter ablations performed in our hospital since January 2017 to June 2021.ResultsA total of 1,853 procedures were performed with 1,957 arrhythmias treated. Rate of fluoroless procedures was 15.4% (285 interventions) with an increasing trend from 8.5% in 2017 to 22.9% of first semester 2021. The most frequent arrhythmia treated was atrial fibrillation (646; 3.6% fluoroless) followed by atrioventricular nodal reentrant tachycardia (644; 16.9% fluoroless), atrial flutter (215; 8.8% fluoroless), ventricular tachycardia (178; 17.4% fluoroless), premature ventricular contraction (162; 48.1% fluoroless), and accessory pathways (112; 31.3% fluoroless). Although characteristics of patients and operative details were heterogeneous among treated arrhythmias, use of fluoroscopy did not influence procedure duration. Moreover, feasibility and efficacy were 100% in fluoroless ablations while the rate of major complications was very low and no different with or without fluoroscopy (0.45 vs. 0.35%).ConclusionLimiting the use of X-Rays is necessary, especially when the available technologies allow a zero-use approach. A lower radiation exposure may be reached, reducing fluoroscopy usage whenever possible during cardiac ablation procedures with high safety, full feasibility, and efficacy.
Serum Chloride Is Inversely Associated With 3 Months Outcomes in Chinese Patients With Heart Failure, a Retrospective Cohort Study
Authors: Fu Zhiqing , An Li , Lu Xiaochun , Sheng Li , Liu Hongbin 
Published: April 2022

BackgroundSerum chloride was recently found to be associated with prognosis of heart failure in western countries. However, the evidence was scarce in Asia. We aimed to investigated the relationship between serum chloride and clinical outcomes in a Chinese cohort with hospitalized heart failure.MethodsWe retrospectively analyzed the data from PhysioNet, involving 1996 patients who were admitted with heart failure between December 2016 and June 2019. Outcome was a composite endpoint of all-cause death or rehospitalization at 3 months.ResultsThe incidence of the composite endpoint was 26.8% (535/1,996); it was 32.2% (213/662), 25.0% (165/661), and 23.3% (157/673) by chloride tertiles (from the lowest to the highest), respectively. The serum chloride at admission was independently and inversely associated with the composite endpoint risk (hazard ratio: 0.967; 95% confidence interval: 0.939 to 0.996; p = 0.026) in contrast to sodium, which was no longer significant (p &gt; 0.05) after multivariable adjustment. Pearson correlation between serum chloride and sodium was 0.747 (p &lt; 0.001). However, an increased AUC was not observed by adding sodium to model composed of age, sex, NYHA class, diabetes, log BNP and chloride (0.620 vs. 0.612, p = 0.132). Subgroup analysis showed the presence or absence of hyponatremia did not affect the association between chloride and composite endpoint risk.ConclusionsLow serum chloride at admission was associated with poor outcomes in Chinese hospitalized patients with heart failure. These findings warrant future studies for tackling the potential pathophysiological mechanisms and correction methods of hypochloremia in heart failure.
Size Distribution of Microparticles: A New Parameter to Predict Acute Lung Injury After Cardiac Surgery With Cardiopulmonary Bypass
Authors: Yuan Hao-Xiang , Liang Kai-Feng , Chen Chao , Li Yu-Quan , Liu Xiao-Jun , Chen Ya-Ting , Jian Yu-Peng , Liu Jia-Sheng , Xu Ying-Qi , Ou Zhi-Jun , Li Yan , Ou Jing-Song 
Published: April 2022

BackgroundAcute lung injury (ALI) is a common complication after cardiac surgery with cardiopulmonary bypass (CPB). No precise way, however, is currently available to predict its occurrence. We and others have demonstrated that microparticles (MPs) can induce ALI and were increased in patients with ALI. However, whether MPs can be used to predict ALI after cardiac surgery with CPB remains unknown.MethodsIn this prospective study, 103 patients undergoing cardiac surgery with CPB and 53 healthy subjects were enrolled. MPs were isolated from the plasma before, 12 h after, and 3 d after surgery. The size distributions of MPs were measured by the LitesizerTM 500 Particle Analyzer. The patients were divided into two subgroups (ALI and non-ALI) according to the diagnosis of ALI. Descriptive and correlational analyzes were conducted between the size distribution of MPs and clinical data.ResultsCompared to the non-ALI group, the size at peak and interquartile range (IQR) of MPs in patients with ALI were smaller, but the peak intensity of MPs is higher. Multivariate logistic regression analysis indicated that the size at peak of MPs at postoperative 12 h was an independent risk factor for ALI. The area under the curve (AUC) of peak diameter at postoperative 12 h was 0.803. The best cutoff value of peak diameter to diagnose ALI was 223.05 nm with a sensitivity of 88.0% and a negative predictive value of 94.5%. The AUC of IQR at postoperative 12 h was 0.717. The best cutoff value of IQR to diagnose ALI was 132.65 nm with a sensitivity of 88.0% and a negative predictive value of 92.5%. Combining these two parameters, the sensitivity reached 92% and the negative predictive value was 96%.ConclusionsOur findings suggested that the size distribution of MPs could be a novel biomarker to predict and exclude ALI after cardiac surgery with CPB.
High-TSH Subclinical Hypothyroidism Is Associated With Postoperative Mortality in Acute Type A Aortic Dissection
Authors: Wang Shi-Pan , Xue Yuan , Li Hai-Yang , Jiang Wen-Jian , Zhang Hong-Jia 
Published: April 2022

BackgroundSubclinical hypothyroidism can negatively affect the cardiovascular system and increase the risk of mortality, especially for individuals with thyroid-stimulating hormone (TSH) levels above 10 mU/L. We investigated the relationship between high-TSH subclinical hypothyroidism and postoperative mortality in acute type A aortic dissection (ATAAD) patients.MethodWe enrolled 146 patients with ATAAD who underwent aortic surgery in Beijing Anzhen Hospital from July 2016 to November 2018. Thyroid hormone levels were obtained before surgery, and participants were divided into a ≥10mU/L TSH level group and a &lt;10mU/L level group. Cox proportional hazard regression and subgroup analysis were conducted to examine the association of preoperative high-TSH subclinical hypothyroidism with postoperative mortality.ResultParticipants with preoperative high-TSH (≥10mU/L) subclinical hypothyroidism tended to have longer hospitalization stays after surgery [16.0 (IQR 11.0-21.0) days vs 12.5 (IQR 8.0-16.0) days, P=0.001]. During the first 30 days after operation, 15 of 146 patients died (10.3%); during a median of 3.16 (IQR 1.76-4.56) years of follow-up, 24 patients died (16.4%). Cox proportional hazard regression showed that preoperative high-TSH subclinical hypothyroidism was independently associated with 30-day mortality (HR=6.2, 95% CI, 1.7-22.0, P=0.005) and postoperative mortality after adjusting for age, sex, BMI, hypertension, ejection fraction, diabetes and history of PCI (HR=3.4, 95% CI, 1.4-8.0, P=0.005).ConclusionThis study showed that preoperative high-TSH subclinical hypothyroidism was an independent predictor of postoperative mortality in ATAAD patients who underwent aortic surgery.
Serum Linkage-Specific Sialylation Changes Are Potential Biomarkers for Monitoring and Predicting the Recurrence of Papillary Thyroid Cancer Following Thyroidectomy
Authors: Cao Zhen , Zhang Zejian , Liu Rui , Wu Mengwei , Li Zepeng , Xu Xiequn , Liu Ziwen 
Published: April 2022

BackgroundAlthough papillary thyroid cancer (PTC) could remain indolent, the recurrence rates after thyroidectomy are approximately 20%. There are currently no accurate serum biomarkers that can monitor and predict recurrence of PTC after thyroidectomy. This study aimed to explore novel serum biomarkers that are relevant to the monitoring and prediction of recurrence in PTC using N-glycomics.MethodsA high-throughput quantitative strategy based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was used to obtain serum protein N-glycomes of well-differentiated PTC, postoperative surveillance (PS), postoperative recurrence (PR), and matched healthy controls (HC) including linkage-specific sialylation information.ResultsSerum N-glycan traits were found to differ among PTC, PS, PR, and HC. The differentially expressed N-glycan traits consisting of sixteen directly detected glycan traits and seven derived glycan traits indicated the response to surgical resection therapy and the potential for monitoring the PTC. Two glycan traits representing the levels of linkage-specific sialylation (H4N3F1L1 and H4N6F1E1) which were down-regulated in PS and up-regulated in PR showed high potential as biomarkers for predicting the recurrence after thyroidectomy.ConclusionsTo the best of our knowledge, this study provides comprehensive evaluations of the serum N-glycomic changes in patients with PS or PR for the first time. Several candidate serum N-glycan biomarkers including the linkage-specific sialylation have been determined, some of which have potential in the prediction of recurrence in PTC, and others of which can help to explore and monitor the response to initial surgical resection therapy. The findings enhanced the comprehension of PTC.
Assessing the Impacts of Climate Change on Meteorology and Air Stagnation in China Using a Dynamical Downscaling Method
Authors: Hu Anqi , Xie Xiaodong , Gong Kangjia , Hou Yuhui , Zhao Zhan , Hu Jianlin 
Published: April 2022

This study utilizes the Weather Research and Forecasting model with a higher resolution (36 km × 36 km) to dynamically downscale the Community Earth System Model results forced by the three representative concentration pathways (RCP) scenarios (RCP4.5, RCP6.0, and RCP8.5) over China. The goal was to compare meteorological fields during the present (2006–2015) and future (2046–2055) climatological periods. An appropriate air stagnation judgment index was selected to explore the effect of climate change on air quality-related meteorological conditions. The results show that the occurrence of wintertime air stagnation over China in the middle of this century (2046–2055) will reduce slightly, with the largest reduction projected under the RCP8.5 scenario (−4 times). However, long-lasting air stagnation events (ASE) are projected to increase in the future, and this increasing trend is more obvious under the RCP8.5 scenario. The projected increase in the long-lasting ASE in different regions of China ranges from 3 to 11 times. Among these, Central China has the largest increase, followed by East and Northeast China, while South China has the lowest increase in ASE. Our results indicate that more attention should be dedicated to extreme pollution events that may potentially be caused by long-lasting air stagnation events in the future.
Circadian Rhythm Sleep Disorders: Genetics, Mechanisms, and Adverse Effects on Health
Authors: Liu Chaoran , Tang Xiangrong , Gong Zishan , Zeng Wang , Hou Qiao , Lu Renbin 
Published: April 2022

Nearly all living organisms, from cyanobacteria to humans, have an internal circadian oscillation with a periodicity of approximately 24 h. In mammals, circadian rhythms regulate diverse physiological processes including the body temperature, energy metabolism, immunity, hormone secretion, and daily sleep-wake cycle. Sleep is tightly regulated by circadian rhythms, whereas a misalignment between the circadian rhythms and external environment may lead to circadian rhythm sleep disorders (CRSD). CRSD includes four main kinds of disorders: the advanced sleep-wake phase disorder (ASPD), the delayed sleep-wake phase disorder (DSPD), the irregular sleep-wake rhythm disorder and the non-24-h sleep-wake rhythm disorder. Recent studies have begun to shed light on the genetic basis of CRSD. Deciphering the genetic codes for ASPD and DSPD has so far been more successful than the other CRSDs, which allow for the development of animal models and understanding of the pathological mechanisms for these disorders. And studies from humans or animal models implicate CRSDs are associated with adverse health consequences, such as cancer and mental disorders. In this review, we will summarize the recent advances in the genetics, underlying mechanisms and the adverse effects on health of ASPD and DSPD.
Low-Osmolar vs. Iso-Osmolar Contrast Media on the Risk of Contrast-Induced Acute Kidney Injury: A Propensity Score Matched Study
Authors: Lee Taeho , Kim Won Ki , Kim Ae Jin , Ro Han , Chang Jae Hyun , Lee Hyun Hee , Chung Wookyung , Jung Ji Yong 
Published: April 2022

Objective:Among the various risk factors associated with contrast-induced acute kidney injury (CI-AKI), the importance of osmolality and viscosity is emerging among the characteristics of contrast media (CM) itself. High osmolality CM (HOCM) is deprecated and low osmotic pressure (LOCM) and iso-osmotic pressure (IOCM) are mainly used in clinical situations where the results of studies on their effect on the development of CI-AKI are contradictory. We evaluated the association between the type of CM and the risk of CI-AKI.Materials and MethodsA retrospective observational cohort study to analyze the effect of the type of CM on the development of CI-AKI. Using propensity score (PS) matching, 2,263 LOCM and IOCM groups were paired for analysis from 5,267 patients and fulfilled the inclusion criteria among 12,742 patients who underwent CAG between 1 January 2007, and 31 December 2016. LOCM included iopromide and iopamidol, IOCM was iodixanol. CI-AKI, which was the primary endpoint, was defined based on the Kidney Disease Improving Global Outcomes criteria within 48 h after exposure to the CM. A multivariable logistic regression analysis was used in the unmatched and matched cohorts, respectively. In addition, a stratified model on clinically important variables, including a high Mehran score (≥ 6), was also used in the matched cohort.ResultsLOCM users showed an increased incidence of CI-AKI (11.7% vs. 9.3%; p = 0.006), but it lost statistical significance after PS matching (9.9% vs. 9.5%, p = 0.725). In multivariable analyses, the adjusted odds ratio for CI-AKI in the LOCM group were 1.059 [95% confidence interval (CI) = 0.875–1.282; p = 0.555] in unmatched cohort and 0.987 (95% CI = 0.803–1.214; p = 0.901) in matched cohort. These results were also consistent with the high-risk (high Mehran score) group.ConclusionsAlthough the role of CM types in the development of CI-AKI has been debated, our observation shows that the selection between LOCM and IOCM during CAG has no influence on the incidence of CI-AKI.
Effects of Sodium Thiosulfate During Resuscitation From Trauma-and-Hemorrhage in Cystathionine-γ-Lyase Knockout Mice With Diabetes Type 1
Authors: Gröger Michael , Hogg Melanie , Abdelsalam Essam , Kress Sandra , Hoffmann Andrea , Stahl Bettina , Calzia Enrico , Wachter Ulrich , Vogt Josef A. , Wang Rui , Merz Tamara , Radermacher Peter , McCook Oscar 
Published: April 2022

BackgroundSodium thiosulfate (STS) is a recognized drug with antioxidant and H2S releasing properties. We recently showed that STS attenuated organ dysfunction and injury during resuscitation from trauma-and-hemorrhage in CSE-ko mice, confirming its previously described organ-protective and anti-inflammatory properties. The role of H2S in diabetes mellitus type 1 (DMT1) is controversial: genetic DMT1 impairs H2S biosynthesis, which has been referred to contribute to endothelial dysfunction and cardiomyopathy. In contrast, development and severity of hyperglycemia in streptozotocin(STZ)-induced DMT1 was attenuated in CSE-ko mice. Therefore, we tested the hypothesis whether STS would also exert organ-protective effects in CSE-ko mice with STZ-induced DMT1, similar to our findings in animals without underlying co-morbidity.MethodsUnder short-term anesthesia with sevoflurane and analgesia with buprenorphine CSE-ko mice underwent DMT1-induction by single STZ injection (100 μg⋅g–1). Seven days later, animals underwent blast wave-induced blunt chest trauma and surgical instrumentation followed by 1 h of hemorrhagic shock (MAP 35 ± 5 mmHg). Resuscitation comprised re-transfusion of shed blood, lung-protective mechanical ventilation, fluid resuscitation and continuous i.v. norepinephrine together with either i.v. STS (0.45 mg⋅g–1) or vehicle (n = 9 in each group). Lung mechanics, hemodynamics, gas exchange, acid–base status, stable isotope-based metabolism, and visceral organ function were assessed. Blood and organs were collected for analysis of cytokines, chemokines, and immunoblotting.ResultsDiabetes mellitus type 1 was associated with more severe circulatory shock when compared to our previous study using the same experimental design in CSE-ko mice without co-morbidity. STS did not exert any beneficial therapeutic effect. Most of the parameters measured of the inflammatory response nor the tissue expression of marker proteins of the stress response were affected either.ConclusionIn contrast to our previous findings in CSE-ko mice without underlying co-morbidity, STS did not exert any beneficial therapeutic effect in mice with STZ-induced DMT1, possibly due to DMT1-related more severe circulatory shock. This result highlights the translational importance of both integrating standard ICU procedures and investigating underlying co-morbidity in animal models of shock research.