bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barium‐doped Sr2Fe1.5Mo0.5O6‐δ perovskite anode materials for protonic ceramic fuel cells for ethane conversion
Authors: Fan Yun , Xi Xiuan , Li Jun , Wang Qi , Xiang Kun , Medvedev Dmitry , Luo Jing‐Li , Fu Xian‐Zhu 
Published: January 2022

AbstractProtonic ceramic ethane fuel cells fed by hydrocarbon fuels are demonstrated to be effective energy conversion devices. However, their practical application is impeded by a lack of anode materials combining excellent catalytic activity with good chemical stability and anti‐carbon deposition properties. In this work, in which Sr2Fe1.5Mo0.5O6‐δ (SFM) double perovskite oxide is used as the matrix framework, catalytic activity toward H2 and C2H6 oxidation is systematically investigated using Ba‐doping. It is found that the concentration of the oxygen vacancy is gradually improved with increased Ba content to significantly enhance catalytic activity toward H2 and C2H6 oxidation. From the series studied, Ba0.6Sr1.4Fe1.5Mo0.5O6‐δ exhibits the highest catalytic activity, while the power densities of the electrolyte‐supported Ba0.6SFM/BaCe0.7Zr0.1Y0.2O3‐δ (BCZY)/La0.58Sr0.4Co0.2Fe0.8O3‐δ (LSCF)‐Sm0.2Ce0.8O2‐δ (SDC) single cell reach 205 and 138 mW cm–2 at 750°C in H2 and C2H6, respectively. The ethane conversion rate of the experimental cell is shown to reach 38.4%, while simultaneously maintaining ethylene selectivity at 95%. Furthermore, the single cell exhibits no significant attenuation during stable operation for 20 h, as well as demonstrating excellent anti‐coking performance. The proposed results suggest that Ba0.6Sr1.4Fe1.5Mo0.5O6‐δ represents a promising anode material for efficient hydrocarbon‐related electrochemical conversion to realize the coproduction of ethylene and power in protonic ceramic ethane fuel cells.
The impact of competitive integrated employment on economic, psychological, and physical health outcomes for individuals with intellectual and developmental disabilities
Authors: Taylor Joshua , Avellone Lauren , Brooke Valerie , Wehman Paul , Inge Katherine , Schall Carol , Iwanaga Kanako 
Published: January 2022

AbstractBackgroundAlthough competitive integrated employment (CIE) has been established as a goal of employment research, policy, and practice for individuals with intellectual and developmental disabilities, the secondary benefits of CIE are rarely discussed.AimsThe purpose of this systematic review was to analyze and synthesise research related to the association between CIE and improved economic, psychological health, and physical health outcomes for individuals with intellectual and developmental disabilities.Materials & MethodsOur review searched peer‐reviewed literature from seven electronic databases and screened 1110 peer‐reviewed articles based on inclusion criteria established following PRISMA guidelines.ResultsOur search procedures produced a final sample of 17 studies.DiscussionImplications of these findings for future research, policy, and practice are provided.ConclusionOur findings showed strong evidence associated with economic outcomes of CIE, moderate associated with psychological health outcomes, and limited evidence related to physical health outcomes.
Effect of electrolyzed water and carbon dioxide microbubbles on removal of diazinon and diazoxon
Authors: Kobayashi Fumiyuki , Aoki Hitoshi , Kamagata Junichi , Odake Sachiko 
Published: January 2022

AbstractEffect of electrolyzed water (EW) produced from sodium chloride solution in a single vessel and carbon dioxide microbubbles (CO2MB) on decomposition of diazinon and its oxidized product, diazoxon, was investigated. Furthermore, these removal by the EW with CO2MB from broccoli‐attached diazinon was examined. Diazinon was oxidized to diazoxon by EW, and the oxidative effect increased with increasing EW concentration from 0.1 to 0.6 mol L−1 or electrolyzing time from 1 to 10 min. However, EW concentration more than 0.2 mol L−1 was required to reduce diazoxon. The effect of EW on the decomposition of diazoxon increased with increasing EW concentration, electrolyzing time or reaction time from 10 to 60 min but decreased by generating CO2MB. Furthermore, diazinon concentration in broccoli was significantly decreased by treatment with deionized water or EW for 10 min, and the removal effect was continued by generating CO2MB in EW until 60 min. The diazoxon concentration in broccoli treated by EW decreased after increased up to 30 min, and the removal effect was increased by generating CO2MB. Also, the pH and available chlorine concentration (ACC) of the EW increased with increasing EW concentration or electrolyzing time but decreased and almost unchanged by generating CO2MB, respectively. Therefore, it was revealed that EW had a decomposition effect on diazinon and diazoxon and that CO2MB promoted the effect of EW on the removal of these pesticides in broccoli. Additionally, the decomposition effect of EW on diazinon and diazoxon was suggested to be influenced by high pH and ACC.Practical ApplicationThe EW produced from NaCl solution in a single vessel is a safer technique easy to be used than that from HCl. In addition, CO2MB has no harmful effects on the human body. This study demonstrated that the EW was effective for decomposing diazinon, an organophosphorus insecticide, and diazoxon, its oxidized product, and that the removal of these pesticides in broccoli by the EW could be more effectively achieved by generating CO2MB. Therefore, the use of EW with CO2MB can be expected to remove pesticides from fruits and vegetables at food factory.
Immune profile by multiplexed immunohistochemistry associated with recurrence after chemoradiation in rectal cancer
Authors: Hong Seung Wook , Lee Seohyun , Kim Yun Jae , Ahn Soyeon , Park In Ja , Hong Seung‐Mo , Hwang Sung Wook , Park Sang Hyoung , Yang Dong‐Hoon , Ye Byong Duk , Byeon Jeong‐Sik , Yang Suk‐Kyun , Kim Jaeil , Kim Sang‐Yeob , Myung Seung‐Jae 
Published: January 2022

AbstractBackground and AimEvidence has emerged that a pretreatment immune profile in rectal cancer is associated with response to chemoradiotherapy (CRT) and recurrence after CRT. However, few studies have evaluated the immune profile differences after CRT regarding recurrence and nonrecurrence.MethodsWe included patients with advanced rectal cancer treated with CRT and surgery with recurrence within 1 year in a recurrence group. After sex and age matching with the recurrence group, patients with no recurrence for 3 years after CRT were included in a nonrecurrence group. We extracted the immune profile, including CD3 and CD8, from the surgical specimen after CRT using multispectral fluorescence immunohistochemistry and compared the two groups.ResultsThe immune profiles of 65 patients with rectal cancer were assessed; 30 were included in the recurrence group and 35 were included in the nonrecurrence group. CD3+ and CD8+ T lymphocyte densities were significantly higher in the nonrecurrence group than in the recurrence group (CD3+; P < 0.001, CD8+; P = 0.003) in the primary tumor. Consistent results were found in epithelial and stromal cells. Compared with the recurrence group, the distinct profiles of co‐expressed immune markers in the nonrecurrence group were revealed (CD3+CD8+, P = 0.001; CD3+CD8+PD‐L1−, P = 0.001; CD3+CD8+ FOXP3− PD‐L1−, P = 0.001).ConclusionsVigorous CD3+ and CD8+ T cell priming post‐CRT was prominent in the nonrecurrence group compared with that of the recurrence group. This finding suggests that differences in immune profiles may have clinical significance even after CRT.
Randomized field trial comparing the efficacy of florfenicol and oxytetracycline in a natural outbreak of calf pneumonia using lung reaeration as a cure criterion
Authors: Jourquin Stan , Bokma Jade , De Cremer Lieze , van Leenen Katharina , Vereecke Nick , Pardon Bart 
Published: January 2022

AbstractBackgroundRespiratory infections are the main indication for antimicrobial use in calves. Optimal treatment duration currently is unknown, but shorter duration would likely decrease selection for antimicrobial resistance.Hypothesis/ObjectivesDetermine differences in cure rate and healing time between animals treated with florfenicol and oxytetracycline in a natural outbreak of respiratory disease using reaeration observed on thoracic ultrasound examination as healing criterion.AnimalsCommercial farm housing 130, 3 to 9 month old Belgian blue beef calves.MethodsRandomized clinical trial during an outbreak of respiratory disease. Metaphylactic treatment was initiated, randomly treating animals with either florfenicol or oxytetracycline. Ultrasonographic follow‐up was done the first day and every other day for a 14‐day period. At the individual animal level, treatment was discontinued when reaeration of the lungs occurred. Differences in cure rate and healing time were determined.ResultsOf the 130 animals studied, 67.7% developed a lung consolidation ≥0.5 cm. The mean ultrasonographic healing time was 2.5 days in the florfenicol group compared to 3.1 days in the oxytetracycline group (P = .04). After single treatment, 80.6% and 60.3% had no consolidations in the florfenicol and oxytetracycline groups, respectively (P = .01). A Mycoplasma bovis strain was genetically and phenotypically determined to be susceptible to both antimicrobials.Conclusions and Clinical ImportanceUltrasonographic lung reaeration shows potential as a cure criterion to rationalize antimicrobial use for outbreaks of pneumonia. In our study, florfenicol resulted in a faster cure and higher reduction in antimicrobial usage than did oxytetracycline.
Formal Jests: the Sonata‐Form Scherzo in Mendelssohn's Mature Chamber Music
Authors: TAYLOR BENEDICT 
Published: January 2022

ABSTRACTOne of the most striking aspects of Mendelssohn's scherzi is his unusual propensity for sonata form in this movement type. Yet in referencing sonata construction, the composer frequently appears to be playing against its norms, taking delight in confounding expectations in the movement's formal twists and turns, as if this ambiguous and ever‐shifting relation were itself a crucial part of the aesthetic quality of the music. The present article examines the manipulations of form present in the sonata‐orientated scherzi of Mendelssohn's mature chamber works from the period 1837–45: those of the String Quartets Op. 44 Nos 2 and 3 and the Piano Trios Op. 49 and Op. 66. In doing so, it makes several significant contributions to current debates about sonata form. First, while continuing the incursion of Formenlehre into the nineteenth century, it brings discussion of sonata form round to address a movement type – the scherzo – not normally considered in recent discussions. Second, the interaction between different formal types posited by these movements has numerous similarities with the dialogic approach foregrounded by James Hepokoski and Warren Darcy's sonata theory. The playful ambiguities suggested by Mendelssohn's scherzi seem particularly suited to a theory in which formal meaning is understood to arise from the productive tension between expectation and realisation, abstract generic norm and particular instantiation. Still, much of Mendelssohn's subtle manipulation of form occurs on the smaller‐scale level of syntax, and one of this study's final implications concerns the interrelation between top‐down, intentional models and bottom‐up, generative approaches to form.
The impact of ABCDE bundle implementation on patient outcomes: A nationwide cohort study
Authors: Frade‐Mera María Jesús , Arias‐Rivera Susana , Zaragoza‐García Ignacio , Martí Joan Daniel , Gallart Elisabet , San José‐Arribas Alicia , Velasco‐Sanz Tamara Raquel , Blazquez‐Martínez Eva , Raurell‐Torredà Marta 
Published: January 2022

AbstractBackgroundThe ABCDE bundle is a set of evidence‐based practices to systematically reduce the risks of sedation, delirium, and immobility in intensive care patients. Implementing the bundle improves clinical outcome.Aims and ObjectivesTo investigate the association between patient outcomes and compliance with bundle components ABC (analgosedation algorithms), D (delirium protocol), and E (early mobilization protocol).DesignA Spanish multicentre cohort study of adult patients receiving invasive mechanical ventilation (IMV) for ≥48 h until extubation.MethodsThe primary outcome was pain level, cooperation to permit Medical Research Council Scale administration, patient days of delirium, and mobility. The secondary outcome was cumulative drug dosing by IMV days. Tertiary outcomes (ICU days, IMV days, bed rest days, ICU mortality, ICUAW) and independent variables (analgosedation, delirium, early mobilization protocols) were also studied.ResultsData were collected from 605 patients in 80 ICUs and 5214 patient days with IMV. Two‐thirds of the ICUs studied applied no protocols. Pain was not assessed on 83.6% of patient days. Patient cooperation made scale administration feasible on 20.7% of days. Delirium and immobility were found on 4.2% and 69.9% of days, respectively. Patients had shorter stays in ICUs with bundle protocols and fewer days of IMV in ICUs with delirium and mobilization bundle components (P = 0.006 and P = 0.03, respectively). Analgosedation protocols were associated with more opioid dosing (P = 0.02), and delirium and early mobilization protocols with more propofol (P = 0.001), dexmedetomidine (P = 0.001), and lower benzodiazepine dosing (P = 0.008).ConclusionsThe implementation rate of ABCDE bundle components was very low in our Spanish setting, but when implemented, patients had a shorter ICU stay, more analgesia dosing, and lighter sedation.Relevance to clinical practiceApplying some but not all the bundle components, there is increased analgesia and light sedation drug use, decreased benzodiazepines, and increased patient cooperation and mobility, resulting in a shorter ICU stay and fewer days of IMV.
Into great silence: Pierre Péju’s La Petite Chartreuse, a contemporary tale of secular pilgrimage
Authors: Ponnou‐Delaffon Erin Tremblay 
Published: January 2022

AbstractLa Petite Chartreuse (2002), penned by the prolific yet understudied novelist and essayist Pierre Péju, charts an unlikely relationship in the wake of a devastating accident. As he walks the Massif de la Chartreuse in the shadow of the Carthusian Grande Chartreuse, a solitary bookseller searches inner depths and mountainous heights before confronting his eponymous young victim’s death—and his own. Informed by the hermeneutical relationship between tale and travel, this chapter reads the novel as a contemporary conte (as theorized by Péju himself), as well as a secular pilgrimage (informed, notably, by Thomas Merton). I contend that Péju’s secular antihero, within (rather than in spite of) physically circumscribed conditions, paradoxically scales spiritual heights epitomized by these two wayfaring narrative traditions. His tale offers a defense and illustration of reading in the face of modernity’s acceleration and dematerialization, challenges contemporary unease before suffering, and belies personal and narrative expectations like progress and harmonious closure. Ultimately, I suggest that Péju plots a profoundly humanistic voyage unto death, as he defamiliarizes the very terrain of these travel genres.
Spermidine enhances the survival of Streptococcus pyogenes M3 under oxidative stress
Authors: Banerji Rajashri , Iyer Parvati , Saroj Sunil D. 
Published: January 2022

AbstractStreptococcus pyogenes, a host‐restricted gram‐positive pathogen during infection, initially adheres to the epithelia of the nasopharynx and respiratory tract of the human host, followed by disseminating to other organs and evading the host immune system. Upon phagocytosis, S. pyogenes encounters oxidative stress inside the macrophages. The role of polyamines in regulating various physiological functions including stress resistance in bacteria has been reported widely. Since S. pyogenes lacks the machinery for the biosynthesis of polyamines, the study aimed to understand the role of extracellular polyamines in the survival of S. pyogenes under oxidative stress environments. S. pyogenes being a catalase‐negative organism, we report that its survival within the macrophages and H2O2 is enhanced by the presence of spermidine. The increased survival can be attributed to the upregulation of oxidative stress response genes such as sodM, npx, and mtsABC. In addition, spermidine influences the upregulation of virulence factors such as sagA, slo, and hasA. Also, spermidine leads to a decrease in hydrophobicity of the cell membrane and an increase in hyaluronic acid. This study suggests a role for extracellular spermidine in the survival of S. pyogenes under oxidative stress environments. Recognizing the factors that modulate S. pyogenes survival and virulence under stress will assist in understanding its interactions with the host.
Risk of retinal disease in patients with bipolar disorder: A nationwide cohort study
Authors: Hsu Tien‐Wei , Bai Ya‐Mei , Tsai Shih‐Jen , Chen Tzeng‐Ji , Liang Chih‐Sung , Chen Mu‐Hong 
Published: January 2022

AimsPatients with brain diseases have been associated with several retinal abnormalities. This study aimed to assess the risk of retinal diseases in patients with bipolar disorder (BD).MethodsThis nationwide cohort of 73,271 patients with BD was enrolled between 2001 and 2009. To identify newly diagnosed retinal diseases, the patients were followed to the end of 2011. The control group included 293,084 patients, matched for demographic characteristics and medical and ophthalmological comorbidities. The Kaplan–Meier method was used to estimate incidence rates of retinal diseases. Cox regression was applied to calculate the hazard ratios (HRs) with 95% confidence intervals (CIs) after adjusting for confounders.ResultsPatients with BD had higher incidence rates of any retinal disease than the controls (1.27% vs 0.48%, P < 0.001), and retinal diseases were diagnosed at a young age (54.23 years [±12.68 years] vs 57.01 years [±13.12 years], P < 0.001). After adjusting for demographic characteristics, physical and ophthalmological comorbidities, and medications, the HR was 3.24 (95% CI, 2.18–4.82) for retinal detachment, 2.35 (95% CI, 1.83–3.03) for primary retinopathy, 2.26 (95% CI, 1.91–2.68) for diabetes retinopathy, 2.39 (95% CI, 1.49–3.82) for hypertensive retinopathy, and 3.46 (95% CI, 2.45–4.89) for retinal vascular complications in patients with BD vs controls. The cumulative daily dose of bipolar medications was not associated with the incidence of any retinal disease.ConclusionPatients with BD were associated with a higher risk of retinal detachment, primary retinopathy, diabetes retinopathy, hypertensive retinopathy, and retinal vascular complications than the controls. Further studies are needed to examine the mechanisms mediating these retinal diseases in patients with BD.
Why is corneal donation so rare in children’s hospices? A survey of multidisciplinary team members attitudes, knowledge, practice, and experience
Authors: Giugni Cristina , Cecchi Costanza , Santucci Claudia , Giometto Sabrina , Lucenteforte Ersilia , Ricci Zaccaria 
Published: January 2022

AbstractBackgroundCorneal donation is a rare event among pediatric patients dying in children's hospices in Italy. Previous research suggests that lack of knowledge and negative attitude of Health Care Professionals (HCPs) are the most relevant factors for low donation rates in hospice, rather than patient ineligibility or public refusal. We conducted a national survey to explore children's hospice staff's knowledge and attitude toward corneal donation, to survey HCPs confidence in discussing the subject with patients and families, to investigate whether staff members receive specific training about corneal donation and its potential impact on the willingness to raise the topic with patients and families.MethodsAn anonymous web‐based survey with multiple‐choice responses was delivered to the team members of seven Italian children's hospices to test their knowledge and attitude about corneal donation.ResultsOf the seven children's hospices approached, four agreed to participate with a response rate of 48.5%. Among respondents, 70% declared that they had not received specific training about corneal donation. Results of statistical analysis showed that there were no significant differences in responses between trained and non‐trained staff and among the different professionals (nurses, doctors, psychologists, AND social workers) regarding confidence in discussing the subject with patients and families.ConclusionsIn our sample of HCPs working in Italian children's hospices, there was no difference in self‐reported trust between professionals who reported receiving specific cornea donation training and those who did not. It is remarkable that training on corneal donation was endorsed by a minority of the sample.
CMV infection and management among pediatric solid organ transplant recipients
Authors: Downes Kevin J. , Sharova Anna , Boge Craig L. K. , Vader Daniel , Mitrou Marina , Hayes Molly , Galetaki Despoina M. , Gianchetti Lauren , Vella Laura A. , Li Yun 
Published: January 2022

AbstractBackgroundCytomegalovirus (CMV) is an important cause of morbidity and mortality in pediatric solid organ transplant (SOT) recipients. However, the impact of asymptomatic CMV infections (ie, DNAemia) on clinical outcomes is not well established.MethodsWe performed a retrospective cohort study of children undergoing first SOT at our institution from January 2012 to June 2018. We evaluated the epidemiology of CMV infections and performed multivariable Cox regression to assess the association between CMV DNAemia without disease or CMV disease (syndrome or end‐organ disease) on negative outcomes (death, re‐transplantation, or moderate/severe rejection) within the first year after SOT.ResultsAmong 271 individuals, 43 (15.9%) developed ≥1 CMV infection during the first year after SOT. There were 56 unique CMV infections including 14 episodes of CMV disease. In 167 patients offered CMV prophylaxis, only 8 (4.8%) developed their first CMV DNAemia episode while on prophylaxis 32 developed CMV DNAemia after prophylaxis completion; only 1 episode of CMV disease occurred while on antiviral prophylaxis. When accounting for receipt of ATG, oral steroids, and number of immunosuppressives on a given day, CMV disease was more strongly associated with negative outcomes (Hazard Ratio (HR): 3.28, 95% CI: 0.73–14.64; p = .12) than CMV DNAemia without disease (HR 1.42, 95% CI: 0.19– 10.79; p = .74), although not to a statistically significant degree.ConclusionsMost CMV infections occurred after completion of antiviral prophylaxis. CMV disease was more strongly associated with negative outcomes than asymptomatic CMV DNAemia and should be the focus of CMV prevention practices.