bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utility of Perioperative Measurement of Cell-Free DNA and Circulating Tumor DNA in Informing the Prognosis of GI Cancers: A Systematic Review
Authors: Hsu Phillip J. , Singh Khushboo , Dhiman Ankit , Witmer Hunter D. D. , He Chuan , Eng Oliver S. , Catenacci Daniel V. T. , Posner Mitchell C. , Turaga Kiran K. 
Published: February 2022

PURPOSE Current surveillance imaging and tumor markers lack sensitivity for the early detection of recurrence in GI cancers. This study critically evaluates the current literature on the role of sequential measurement of circulating tumor DNA (ctDNA) before and after curative resection in informing recurrence. METHODS A systematic search using a predefined, registered protocol was conducted for studies published between January 2010 and May 2020. Included studies described patients with GI cancers treated with curative-intent surgical resection and measurement of ctDNA both before and after surgery. Patients were divided into three groups on the basis of the presence or absence of ctDNA at these time points. The primary outcome was recurrence-free survival (RFS). RESULTS The search yielded 3,873 articles; five met the inclusion criteria and collectively evaluated 57 patients. Pooled median RFS was 62 months (interquartile range 19 to not reached). Although median RFS was not reached in group 1 (– to –) or group 2 (+ to –), median RFS in group 3 (+ to +) was 15 months (interquartile range 9.6-60.4 months). Cox hazard ratio was 4.46 (95% CI, 1.17 to 16.99; P = .028) between group 1 and group 2, and 10.47 (95% CI, 2.91 to 37.74; P < .001) between group 2 and group 3. CONCLUSION Detectable ctDNA, either preoperatively or postoperatively, and its persistence after curative surgery are associated with a greater risk of recurrence and decreased RFS in GI cancers. Thus, perioperative measurement of ctDNA may be a useful postoperative risk stratification tool and guide additional therapies.
Biochemical Markers of Bone Turnover in Older Adults With Type 1 Diabetes
Authors: Rubin Mishaela R , de Boer Ian H , Backlund Jye-Yu C , Arends Valerie , Gubitosi-Klug Rose , Wallia Amisha , Sinha Gregory Naina , Barnie Annette , Burghardt Andrew J , Lachin John M , Braffett Barbara H , Schwartz Ann V 
Published: February 2022

Abstract

Context
Type 1 diabetes (T1D) is characterized by high fracture risk, yet little is known regarding diabetes-related mechanisms or risk factors.

Objective
Determine whether glycemic control, advanced glycation end products (AGEs), and microvascular complications are associated with bone turnover markers among older T1D adults.

Design
Cross-sectional.

Setting
Epidemiology of Diabetes Interventions and Complications study (6 of 27 clinical centers).

Participants
232 T1D participants followed for &gt;30 years.

Exposures
Glycemic control ascertained as concurrent and cumulative hemoglobin A1c (HbA1c); kidney function, by estimated glomerular filtration rates (eGFR); and AGEs, by skin intrinsic fluorescence.

Main Outcome Measures
Serum procollagen 1 intact N-terminal propeptide (PINP), bone-specific alkaline phosphatase (bone ALP), serum C-telopeptide (sCTX), tartrate-resistant acid phosphatase 5b (TRACP5b), and sclerostin.

Results
Mean age was 59.6 ± 6.8 years, and 48% were female. In models with HbA1c, eGFR, and AGEs, adjusted for age and sex, higher concurrent HbA1c was associated with lower PINP [β −3.4 pg/mL (95% CI −6.1, −0.7), P = 0.015 for each 1% higher HbA1c]. Lower eGFR was associated with higher PINP [6.9 pg/mL (95% CI 3.8, 10.0), P &lt; 0.0001 for each −20 mL/min/1.73 m2 eGFR], bone ALP [1.0 U/L (95% CI 0.2, 1.9), P = 0.011], sCTX [53.6 pg/mL (95% CI 32.6, 74.6), P &lt; 0.0001], and TRACP5b [0.3 U/L (95% CI 0.1, 0.4), P = 0.002]. However, AGEs were not associated with any bone turnover markers in adjusted models. HbA1c, eGFR, and AGEs were not associated with sclerostin levels.

Conclusions
Among older adults with T1D, poor glycemic control is a risk factor for reduced bone formation, while reduced kidney function is a risk factor for increased bone resorption and formation.
A deep-dive into fictive locomotion – a strategy to probe cellular activity during speed transitions in fictively swimming zebrafish larvae
Authors: Koning Harmen Kornelis , Ahemaiti Aikeremu , Boije Henrik 
Published: February 2022

ABSTRACT
Fictive locomotion is frequently used to study locomotor output in paralyzed animals. We have evaluated the character of swim episodes elicited by different strategies in zebrafish. Motor output was measured on both sides of a body segment using electrodes and a pipeline for synchronizing stimulation and recording, denoising data and peak-finding was developed. The optomotor response generated swims most equivalent to spontaneous activity, while electrical stimulation and NMDA application caused various artefacts. Our optimal settings, optomotor stimulation using 5-day-old larvae, were combined with calcium imaging and optogenetics to validate the setup's utility. Expression of GCaMP5G by the mnx1 promoter allowed correlation of calcium traces of dozens of motor neurons to the fictive locomotor output. Activation of motor neurons through channelrhodopsin produced aberrant locomotor episodes. This strategy can be used to investigate novel neuronal populations in a high-throughput manner to reveal their role in shaping motor output.
This article has an associated First Person interview with the first author of the paper.
Decoupling SARS-CoV-2 ORF6 localization and interferon antagonism
Authors: Wong Hoi Tong , Cheung Victoria , Salamango Daniel J. 
Published: February 2022

ABSTRACT
Like many pathogenic viruses, SARS-CoV-2 must overcome interferon (IFN)-mediated host defenses for infection establishment. To achieve this, SARS-CoV-2 deploys overlapping mechanisms to antagonize IFN production and signaling. The strongest IFN antagonist is the accessory protein ORF6, which localizes to multiple membranous compartments, including the nuclear envelope, where it directly binds nuclear pore component Nup98–Rae1 to inhibit nuclear translocation of activated STAT1 and IRF3 transcription factors. However, this direct cause-and-effect relationship between ORF6 localization and IFN antagonism has yet to be explored experimentally. Here, we use extensive mutagenesis studies to define the structural determinants required for steady-state localization and demonstrate that mis-localized ORF6 variants still potently inhibit nuclear trafficking and IFN signaling. Additionally, expression of a peptide that mimics the ORF6–Nup98 interaction domain robustly blocked nuclear trafficking. Furthermore, pharmacologic and mutational approaches combined to suggest that ORF6 is likely a peripheral membrane protein, as opposed to being a transmembrane protein as previously speculated. Thus, ORF6 localization and IFN antagonism are independent activities, which raises the possibility that ORF6 may have additional functions within membrane networks to enhance virus replication.
This article has an associated First Person interview with the first author of the paper.
Changes in apolipoprotein abundance dominate proteome responses to prolonged fasting in elephant seals
Authors: Khudyakov Jane I. , Holser Rachel R. , Vierra Craig A. , Ly Serena T. , Niel Theron K. , Hasan Basma M. , Crocker Daniel E. , Costa Daniel P. 
Published: February 2022

ABSTRACT
Unlike many animals that reduce activity during fasting, northern elephant seals (NES) undergo prolonged fasting during energy-intensive life-history stages such as reproduction and molting, fueling fasting energy needs by mobilizing fat stores accrued during foraging. NES display several unique metabolic features such as high fasting metabolic rates, elevated blood lipid and high-density lipoprotein (HDL) cholesterol levels, efficient protein sparing and resistance to oxidative stress during fasting. However, the cellular mechanisms that regulate these adaptations are still not fully understood. To examine how metabolic coordination is achieved during prolonged fasting, we profiled changes in blubber, skeletal muscle and plasma proteomes of adult female NES over a 5 week fast associated with molting. We found that while blubber and muscle proteomes were remarkably stable over fasting, over 50 proteins changed in abundance in plasma, including those associated with lipid storage, mobilization, oxidation and transport. Apolipoproteins dominated the blubber, plasma and muscle proteome responses to fasting. APOA4, APOE and APOC3, which are associated with lipogenesis and triglyceride accumulation, decreased, while APOA1, APOA2 and APOM, which are associated with lipid mobilization and HDL function, increased over fasting. Our findings suggest that changes in apolipoprotein composition may underlie the maintenance of high HDL levels and, together with adipokines and hepatokines that facilitate lipid catabolism, may mediate the metabolic transitions between feeding and fasting in NES. Many of these proteins have not been previously studied in this species and provide intriguing hypotheses about metabolic regulation during prolonged fasting in mammals.
Catalytic Magnesium-Oppenauer Oxidation of Alcohols
Authors: Sasaki Yuta , Yokoo Kazuma , Mori Keiji 
Published: February 2022

Abstract
A catalytic magnesium-Oppenauer oxidation reaction was developed. When a solution of alcohols in toluene was successively treated with 15–30 mol % of EtMgBr and 1.0 equiv. of trifluoromethyl ketone (oxidant), a hydride transfer-type oxidation reaction (Oppenauer oxidation) occurred to give corresponding ketones in good chemical yields (up to 85%). It was noteworthy that even a weakly basic alkoxide derived from trifluoromethyl ketone worked as an efficient Brønsted base to deprotonate the starting material (alcohols) at ambient temperature (25 °C). The efficiency of the present method was highlighted by applying the method to substrates having a nitrogen atom, which were sensitive to various oxidation conditions.
Pelatihan Pemanfaatan Drone dan Aplikasi Digital untuk Menunjang Sektor Agro Maritim di Kabupaten Tulungagung
Authors: Siswantoro Nurhadi , Pitana Trika , Zaman Muhammad Badrus , Priyanta Dwi , Prastowo Hari 
Published: February 2022

Budidaya perikanan tawar di Kabupaten Tulungagung merupakan salah satu penghasil produksi ikan tawar terbesar di Jawa Timur. Produksi perikanan air tawar di Kabupaten Tulungagung terbagi menjadi ikan hias dan konsumsi, seperti: lele, gurami, patin dan nila. Kabupaten Tulungagung dengan potensi perikanan tawar memerlukan teknologi digital informasi dan inovasi dalam mengelola sumber daya perikanan. Penggunaan teknologi seperti drone juga dapat dimanfaatkan untuk menunjang pemasaran digital maupun inovasi pada pemberian pakan ikan secara otomatis. Penggunaan drone di bidang digital marketing dapat memberikan banyak kelebihan khususnya dalam efisiensi waktu. Kelebihan drone adalah sebagai berikut, fleksibilitas sangat tinggi, menghasilkan resolusi sangat tinggi, automatic/manual operation sesuai kebutuhan. Untuk inovasi pemberian pakan ikan secara otomatis, drone buatan Laboratorium Digital Marine Operation and Mainenance ITS memiliki kemampuan jangkauan remotely 1 kilometer dan kemampuan terbang selama 20 menit, serta membawa beban 4 kilogram. Pada simulasi pemberian pakan ikan, drone diterbangan dengan membawa pakan seberat 1 kilogram dan secara remote pakan otomatis dituangkan ke kolam. Hasilnya ikan tidak merasa terganggu dengan suara drone dan langsung menyambar pakan ikan yang jatuh dari atas drone. Simulasi pemanfaatan drone untuk pemberian pakan ikan, memberikan wawasan dan pandangan terhadap petani ikan bahwa saat ini teknologi agro maritim harus berinovasi untuk meningkatkan produktifitas perikanan.
Design Method and Experimental Study of a Rice Transplanting Mechanism with Three Planting Arms Constrained by Differential Noncircular Gear Trains
Authors: Zhou Maile , Yang Jiajia , Yin Jianjun , Wang Zeliang 
Published: February 2022

HighlightsThe fuzzy transplanting requirements were transformed into optimization targets.A transplanting mechanism constrained by differential noncircular gear trains was designed.The optimal software design of the transplanting mechanism was developed.The designed transplanting mechanism realized the trajectory and attitude required for rice transplanting.Abstract. The transplanting mechanism is the core working part of a rice transplanter, and its working cycle includes the stages of picking, transporting, planting, and returning. Aimed at the problems of poor working precision, poor trajectory and attitude, and low operating efficiency of the existing transplanting mechanism of rice transplanters, a transplanting mechanism with three planting arms constrained by differential noncircular gear trains was designed to avoid the side gap accumulation caused by unequal multistage speed transmission. The movement of the 2R open-chain mechanism was constrained by a differential noncircular gear train so that the connecting rod could realize the trajectory and attitude required for rice transplanting. Based on the unequal speed transmission of differential noncircular gear trains, a kinematic model of the transplanting mechanism with three planting arms was established, and the optimal software design of the transplanting mechanism was developed in a visual programming environment. Based on the agronomic requirements for rice transplanting, the optimization design targets of the transplanting mechanism were customized, the functional relationship between the optimization targets and parameters was established, and the optimization targets were embedded into the optimal software design. Through parameter optimization, a set of mechanism parameters meeting the requirements of the trajectory and attitude for rice transplanting were obtained, and the structural design of the transplanting mechanism was completed. Virtual simulation experiments and bench experiments with the transplanting mechanism with three planting arms constrained by differential noncircular gear trains showed that the transplanting mechanism accurately realized the trajectory and attitude required for rice transplanting. Keywords: 2R open-chain mechanism, Differential gear, Noncircular gear, Rice transplanter, Transplanting mechanism.
Transcendental Arguments and the Sources of Value: Constitutivism as Critical Realism
Authors: Lovelli Linda 
Published: February 2022

AbstractIn this paper, I present different ways in which transcendental argumentation has been used in contemporary debates in moral philosophy to justify the normative authority of morality. My aim is to defend strong “retorsive” transcendental argumentation as a way to ground a sort of critical realism in metaethics, comparing transcendental arguments proposed by Karl-Otto Apel, Christine Korsgaard and Alan Gewirth – which are sometimes referred to as “constitutivist” arguments. In particular, I endorse an argumentative strategy that considers the merits of the respective positions while overcoming the limits of each. Such a strategy aims at grounding transcendentally the metaphysical fact of human value, making explicit the ontological implications of transcendental argumentation, and showing that a justification of fundamental values alone can ultimately make it possible to ground basic moral principles.
The L

p
dual Minkowski problem about 0 < p < 1 and q > 0
Authors: Lu Fangxia , Pu Zhaonian 
Published: February 2022

Abstract
The (

p
,
q

p,q

)-th dual curvature measures and the

L

p

{L}_{p}

dual Minkowski problem were recently introduced by Lutwak, Yang, and Zhang. In this paper, we give a solution to the existence part of the

L

p

{L}_{p}

dual Minkowski problem about

0
<
p
<
1

0\lt p\lt 1

and

q
>
0

q\gt 0

for arbitrary measures. This fills up previously obtained results.
High performance multifunction-in-one optoelectronic device by integrating graphene/MoS2 heterostructures on side-polished fiber
Authors: Zhuo Linqing , Li Dongquan , Chen Weidong , Zhang Yu , Zhang Wang , Lin Ziqi , Zheng Huadan , Zhu Wenguo , Zhong Yongchun , Tang Jieyuan , Lu Guoguang , Fang Wenxiao , Yu Jianhui , Chen Zhe 
Published: February 2022

Abstract
Two-dimensional (2D) materials exhibit fascinating and outstanding optoelectronic properties, laying the foundation for the development of novel optoelectronic devices. However, ultra-weak light absorption of 2D materials limits the performance of the optoelectronic devices. Here, a structure of MoS2/graphene/Au integrated onto the side-polished fiber (SPF) is proposed to achieve a high-performance fiber-integrated multifunction-in-one optoelectronic device. It is found that the device can absorb the transverse magnetic (TM) mode guided in the SPF and generate photocurrents as a polarization-sensitive photodetector, while the transverse electric (TE) mode passes with low loss through the device, making the device simultaneously a polarizer. In the device, the MoS2 film and the Au finger electrode can enhance the TM absorption by 1.75 times and 24.8 times, respectively, thus allowing to achieve high performance: a high photoresponsivity of 2.2 × 105 A/W at 1550 nm; the external quantum efficiency (EQE) of 1.76 × 107%; a high photocurrent polarization ratio of 0.686 and a polarization efficiency of 3.9 dB/mm at C-band. The integration of 2D materials on SPF paves the way to enhance the light–2D material interaction and achieve high performance multifunction-in-one fiber-integrated optoelectronic devices.
Wahrnehmungen digitaler Transformation im Medizinwesen – Potenziale für Krankenhausseelsorge sowie kritische Rückfragen
Authors: Neuhold David 
Published: February 2022

Zusammenfassung
Der Beitrag untersucht explorativ mögliche und bereits vor sich gehende Veränderungen im Bereich von Digital Health und bezieht diese auf das Feld der Krankenhausseelsorge. Dabei stehen im Beitrag der „aufgewertete Patient bzw. die aufgewertete Patientin“, möglicherweise flacher sich zeigende Hierarchien im Spitalswesen und die zunehmende Transformation des Spitals als Zentralort des Medizinsystems besonders im Blickfeld. Das Spital scheint sich unter dem Paradigma von Tele-Health institutionell besonders stark zu verändern. Alle Entwicklungen bieten Chancen für das Feld spiritueller Begleitung und Betreuung. Das digitale Phänomen als etwas Neues wird aber vielfach auch enorm hoch gewertet – so z. B. in der Ansicht, dass der digitale „Drift“, den wir erleben, als neue vierte Dimension von Gesundheit mit zu bedenken sei.
Selección clonal de Tectona grandis L. f. para el Pacífico seco de Costa Rica
Authors: Badilla-Valverde Yorleny , Murillo-Gamboa Olman 
Published: February 2022

La teca es una de las especies comerciales plantadas en el trópico con mayor valor en el mundo. La cooperativa internacional de mejoramiento genético GENFORES, establecida en Costa Rica, ha liderado el mejoramiento genético de la especie en América Latina. El estudio se realizó con el objetivo de seleccionar los clones con mayor adaptabilidad específica al Pacífico seco de Costa Rica y de otras regiones tropicales secas. La investigación se desarrolló en Nicoya, Guanacaste (Pacífico norte de Costa Rica), donde se evaluaron 31 genotipos durante 13 años continuos (2006-2019), con base en el crecimiento en diámetro, volumen comercial y la calidad del fuste. Mediante el software Selegen-REML/BLUP se obtuvieron los parámetros genéticos, el ranking de selección y la ganancia genética estimada. A los 8,9 años fue la edad más temprana donde se registraron los valores más altos de heredabilidad individual y de heredabilidad media clonal para el diámetro (h2g = 0,12 y h2mc = 0,82) y para el volumen comercial (h2g = 0,075 y h2mc = 0,74). Plantaciones comerciales establecidas con los mejores 10 clones, a los 12,9 años de edad podrían alcanzar un volumen comercial de 0,88 m3árbol-1, que corresponde a una ganancia genética de un 11% con respecto a la mejor semilla comercial disponible del huerto semillero. El diámetro alcanzaría 28 cm a esta misma edad. Tales resultados permitirán reducir cerca de 2 años la edad de cosecha de plantaciones de teca en el Pacífico seco del país.
Strategi Brand Activation Bandeng Mentari UMKM UD. Sarana Multi Niaga Kabupaten Gresik
Authors: Retpitasari Ellyda , Muchlis Muchlis 
Published: February 2022

Dalam penelitian ini, peneliti membahas tentang strategi brand activation bandeng mentari usaha mikro, kecil, dan menengah (UMKM) UD. Sarana Multi Niaga Kabupaten Gresik. Tujuan dalam penelitian ini adalah untuk mengetahui tentang strategi brand activation yang digunakan UMKM UD. Sarana Multi Niaga Kabupaten Gresik dalam rangka untuk mewujudkan awareness konsumen, dan bentuk brand activation yang digunakan UMKM UD. Sarana Multi Niaga dalam rangka untuk mewujudkan awareness. Metode penelitian ini menggunakan metode kualitatif deskriptif.
Hasil penelitian ditemukan bahwa, UMKM UD. Sarana Multi Niaga menjalankan strategi melalui segmentation, targeting dan positioning. Kemudian bentuk brand activation menggunakan sponshorship, product trial, dan direct selling. Strategi dan bentuk brand activation itu digunakan untuk mewujudkan kesadaran merek (brand awareness) dari konsumen, hal tersebut diwujudkan dengan brand Bandeng Mentari dikenal sebagai kearifan lokal dari kabupaten Gresik.
Komunikasi Transendental Penderita Kanker di Yayasan Kanker Indonesia Cabang Jawa Timur
Authors: Asmaai Mashfiyatul 
Published: February 2022

Penelitian ini membahas tentang tentang komunikasi transendental penderita kanker di Yayasan Kanker Indonesia Cabang jawa Timur. Segala hal yang dilakukan oleh penderita kanker dalam berkomunikasi dengan Tuhannya dikaji dalam penelitian ini. Penelitian ini menggunakan jenis penelitian kualitatif dengan pendekatan fenomenologi.
Hasil penelitian menunnjukkan bahwa penderita kanker menyampaikan pesan tentang kematian beserta kehidupan setelahnya. Pesan-pesan tersebut disampaikan penderita kanker menggunakan media yang memanfaatkan ibadah dan juga aktivitas sosial yang dilakukan sehari-hari. Model komunikasi komunikasi transendental penderita kanker terjadi secara vertikal yaitu langsung kepada Allah dan juga secara horizontal yaitu menyamping kepada sesama makhluk Allah dengan memperhatikan esensi pesan yang tujuannya tetap kepada Allah.
Berdasarkan hasil dari penelitian ini, peneliti menyarankan agar seluruh masyarakat mendukung pengobatan penderita kanker baik berupa materi maupun berupa dukungan spiritual. Karena segala bentuk perhatian dan dukungan sekecil apapun dapat berpengaruh bagi kekuatan mental dan kondisi psikologis penderita kanker yang nantinya akan berpengaruh terhadap perkembangan kesehatannya.