bluuebunny/crossref_metadata_2025_split huggingface dataset:
820 New Insights into the Genomic Landscape of Skull Base Meningiomas
Authors: Alsahlawi Aysha , Abedalthagafi Malak 
Published: March 2022

INTRODUCTION:
The management of skull base meningiomas is challenging due to their complexity and proximity to crucial nearby structures. The identification of oncogenic mutations has provided further insights into the tumorigenesis of meningioma and the possibility of targeted therapy.

METHODS:
Tissue samples were collected from 71 patients diagnosed with meningioma from 2008 to 2016. Tissues were treated and archived as formalin-fixed paraffin-embedded (FFPE). Samples were subjected to targeted sequencing using a customized gene panel.

RESULTS:
The study cohort comprised 71 patients with histologically proven meningioma (grades I, II, and III) .The median patient age was 54.8 years (range 27-96 years). Most of the patients were female (51/71, 72.82%), while 19/71 (27.14%) were male. 56/71 patients had grade I (80.0%), 13/71 (18.57%) had grade II and 1/71 (1.428%) had grade III tumors. A total of 51/71 of the tumors were found in the skull base (72.82%). 22/71 (31.42%) of the tumors were meningothelial, 6/71 (8.57%) were atypical, 6/71 (8.57%) were transitional, 3/71 (4.28) were secretory, and 2/71 (2.86%) were chordoid. We detected an average of 1.56 ± 1.07 genomic alterations (GAs) per patient. the most common mutations were in NF2 (52/71), PIK3CA (22/71), FGFR3 (13/71), SMO (11/71) and AKT1 (10/71), with Tertp (1/71) mutations being the least frequent. The NF2-positive tumors were predominantly of grade I 43/52 (82.69%) with lower rates of recurrence (7/52, 13.41%) in tumors harboring NF2 mutations compared to tumor harboring non-NF2 mutations (8/18, 44.44%). Single FGFR3 mutations reported in three patients, all had WHO grade I tumors, with no recurrence in our cohort.

CONCLUSIONS:
This cohort focusing skull base meningiomas, highlights a range of mutations outside the known cancer driver NF2 that may be linked to meningioma prognosis. Among our findings were the identification of a rare TERTp mutation and the first report of FGFR3 mutations that may represent biomarkers for the identification of skull base meningioma patients with a favorable prognosis. Taken together, these findings highlight how genetic profiling can guide optimal treatment strategies, prognostic prediction, and patient management for skull meningioma.
827 Trends of In-patient Use of Patient-provider Video Recording During COVID19 Era and its Effects on HCAHPS Scores
Authors: Naeem Komal , Bhargava Malika , Porter Randall W. 
Published: March 2022

INTRODUCTION:
Visitation restriction during COVID19 hindered the provision of optimal care provision. The presence of attendants with the family has proven to be beneficial for the patient’s recovery. The family of unconscious patients also liked to be updated periodically. We introduced the facility of video recording the patient and healthcare provider interaction that were made readily available for the patient and their family member.

METHODS:
We analyzed the number of videos recorded from July 2020 to Nov 2020. We also studied the change in the hospitals’ HCAHPs scores during the time.

RESULTS:
In total, 34,603 videos were recorded for the admitted patients, providing the details of daily progress. These videos received 44,981 (129%) views and 13,704 videos (39.6%) were shared with a total watch time of 1,081.5 hours. From 7/20 to 11/20 an increasing trend was seen in HCAHPS scores for the hospital and an R2 of 0.26 was calculated. A qualitative analysis of patients comments about their care revealed that they found the videos “comforting”, “communicate effectively”, “helpful”, “I do not need to call”.

CONCLUSIONS:
This study shows the benefits of providing a video recording of daily follow-up of hospitalized patients. We report an increasing trend in the HCAHPS scores. Not only patients/caregivers were able to watch the videos but they were shared with loved ones as well.
837 Shunt-dependent Post Traumatic Hydrocephalus in Pediatric Patients with Moderate to Severe Traumatic Brain Injury (TBI)
Authors: Asemota Anthony O. , Schneider Eric 
Published: March 2022

INTRODUCTION:
Post-traumatic hydrocephalus (PTH) is a sequela of traumatic brain injury (TBI) causing significant morbidity among patients and treatment often requires placement of ventriculoperitoneal (VP) shunts. It is especially concerning in children given the often-lifelong dependency and quality-of-life issues over their life course.

METHODS:
The Nationwide Inpatient Sample 2000-2014 was queried and patients =18 years with moderate-severe TBI identified using ICD-9-CM codes. Weighted-data was analyzed and outcomes examined.

RESULTS:
A total 328,971 pediatric TBI cases were identified. Most patients were male (67.26%). The mean patient age was 9.74 years (SD=6.63), median 12 years (IQR=3-16). Age-group categories were: <1-year (14.58%), 1-9 years (30.14%), 10-19 years (55.28%). Majority of cases were treated at teaching hospitals (81.98%). The most common injury-causes were falls (20.35%) followed by motor-vehicle accidents (18.47%). Approximately 1.47% developed PTH requiring VP-shunt placement. By age-group, VP-shunt placement occurred in <1-year (3.69%), 1-9 years (1.14%), 10-19 years (1.07%), P<0.001. The mean age of patients developing shunt-dependent PTH was 6.95 years (SD=7.08), median age 4 years (IQR=0-14). After multivariate regression, patients with shunt-dependent PTH demonstrated higher odds of inpatient mortality (OR=1.29; 95%CI=1.02-1.62, P<0.001), tracheostomy (OR=5.93; 95%CI=4.75-7.40, P<0.001) and PEG-placement (OR=5.54; 95%CI=4.40-6.96, P<0.001), and also demonstrated significantly higher odds of medical complications including pulmonary insufficiency (OR=2.36; 95%CI=1.98-2.81, P<0.001), acute respiratory failure (OR=2.58; 95%CI=2.15-3.10, P<0.001), deep-vein thrombosis (OR=5.42; 95%CI=3.57-8.21, P<0.001), pulmonary embolism (OR=3.31; 95%CI=1.01-10.82, P=0.04), ventilator associated pneumonia (OR=2.20; 95%CI=1.07-4.52, P<0.001), congestive cardiac failure (OR=4.64; 95%CI=1.81-11.90, P<0.001), acute renal failure (OR=2.57; 95%CI=1.45-4.56, P<0.001), sepsis (OR=2.87; 95%CI=1.49-5.52, P<0.001), and severe sepsis (OR=4.12; 95%CI=1.89-8.97, P<0.001).

CONCLUSIONS:
Pediatric TBI patients developing shunt-dependent PTH have significantly higher inpatient morbidity and mortality. Research to better understand factors associated with post-traumatic hydrocephalus in pediatric patients are warranted.
Random attention can explain apparent object choice behavior in free-walking blowflies
Authors: Monteagudo José , Egelhaaf Martin , Lindemann Jens Peter 
Published: March 2022

ABSTRACT
Flies are often observed to approach dark objects. To a naive observer they seem to pay selective attention to one out of several objects although previous research identified as a possible underlying mechanism a reflex-like fixation behavior integrating responses to all objects. In a combination of behavioral experiments and computational modelling, we investigated the choice behavior of flies freely walking towards an arrangement of two objects placed at a variable distance from each other. The walking trajectories were oriented towards one of the objects much earlier than predicted by a simple reactive model. We show that object choice can be explained by a continuous control scheme in combination with a mechanism randomly responding to the position of each object according to a stochastic process. This may be viewed as a special form of an implicit attention-like mechanism, for which the model does not require an explicit decision mechanism or a memory for the drawn decision.
Case Report: Bocavirus Infection Radiologically Resembling a Congestive Heart Failure in a Patient with Metastatic Castration-Resistant Prostate Cancer
Authors: Benitez Fuentes Javier David , de Luna Aguilar Alicia , Flores Navarro Paloma , Lopez de Sa Lorenzo Alfonso , Toledano Rojas Carmen , Laguna Fonseca Berta , Shah Richa , Frick Clara , Jimenez Ortega Alejandro Francisco , Rocha Iñigo Tania , Vidal Cassinello Natalia 
Published: March 2022

Background: Human bocavirus (HBoV) is a viral pathogen from the genus Bocaparvovirus (family Parvoviridae, subfamily Parvovirinae) discovered in 2005. Most of available literature is about HBoV in children and adults with hematological malignancies and in otherwise healthy children with respiratory infections. Information regarding infection in the adult population with solid tumors is scarce. Case Report: We report the case of a 51-year-old male with metastatic castration resistant prostate cancer undergoing chemotherapy treatment who presented with fever, dyspnea, dry cough, and pleuritic pain. Imaging techniques showed signs of congestive heart failure. Symptoms, laboratory tests and echocardiography revealed a more probable infectious etiology. Antibiotic therapy was started. A polymerase chain reaction (PCR) test of nasopharyngeal exudate for respiratory viruses was positive for HBoV. The rest of the microbiological tests were negative. Bronchoalveolar lavage (BAL) was performed. Bacterial culture of BAL was negative while respiratory virus PCR confirmed positivity for HBoV. Antibiotic therapy was discontinued. The patient gradually recovered. Conclusions: Emerging infectious diseases are a notorious threat for immunocompromised populations such as solid tumor patients. This case is unique because to our knowledge this is the first case report article of HBoV in a solid tumor patient and because imaging techniques exhibited signs of congestive heart failure that did not correlate with the rest of the tests. It shows that unusual pathogens should be considered when managing serious clinical complications with uncommon presentations in cancer patients. Notable diagnostic efforts should be made to reach a diagnosis in these cases.
The stock market reaction to COVID-19 vaccination in ASEAN
Authors: Herlina Marizsa , Mafruhat Ade Yunita , Kurniati Eti , Wildan Wildan , Salsabila Hilwa Gifty 
Published: March 2022

Previous studies have shown that the confirmed cases drive investor sentiment, reflecting the stock's return. Based on this, the vaccination growth is also expected to drive the investor’s sentiment, which can be reflected in the return of the stock market in ASEAN. Therefore, this study explores the vaccination impact on stock returns in ASEAN countries. This study contributes to the gap of taking the COVID-19 vaccination impact to the stock return into account by using the panel regression model with HC and Driscoll and Kraay robust covariance matrix estimator, which addresses the cross-dependency and heterogeneity problems. This study is one of the early studies of the topic, especially in ASEAN. The panel regression model with HC and Driscoll and Kraay robust covariance matrix estimator uses three variables: the daily stocks return, vaccine growth, and cases growth. It is a balanced panel data that includes six countries and 117 daily series data, making 702 observations used in the study. The results show conflicting results where daily vaccination growth negatively affects the stock return. This problem can arise for several reasons, such as the uncertainty in the financial market and cross-dependency and heterogeneity detected in the model. We can see that the investors still have a negative sentiment because COVID-19 has resulted in uncertainty on the financial market in ASEAN. This gives us practical implications that the ASEAN country members’ government needs to push vaccination policy more aggressively.
First population norms for the EQ-5D-3L in the Russian Federation
Authors: Khabibullina Alina , Aleksandrova Ekaterina , Gerry Christopher J. , Vlassov Vasily 
Published: March 2022

PurposeThe EQ–5D survey instrument is routinely applied to general and patient specific populations in many countries, as a means of measuring Health Related Quality of Life (HRQOL) and/or informing Health Technology Assessment. The instrument is the subject of growing interest in the Russian Federation, as too is Health Technology Assessment. This research is the first to systematically present the EQ–5D–3L nationally representative population norms and to examine the socioeconomic and socio-demographic characteristics of the instrument among a representative sample of the Russian population.MethodsBased on a nationally representative health and well-being survey of the Russian population, conducted in November 2017, we establish the descriptive results, including the EQ-VAS and the EQ-5D Index, by age and gender, examine the correspondence between the EQ–5D health classifications and the separate EQ-VAS scores, and draw on a set of augmented logistic regressions to evaluate the association between the presence of problems in each dimension and various socio-economic and health-related characteristics.ResultsWe find strong evidence that the EQ-5D instrument is sensitive to underlying observed and latent health experiences, that it mirrors many of the characteristics familiar from other settings but that there are Russian specificities which merit further research, particularly with respect to the anxiety/depression dimension of the instrument.ConclusionThis research represents an important landmark for HRQOL studies in Russia as well as for the prospects of continuing to develop the scholarly and practical infrastructure necessary for Russian Health Technology Assessment to advance.
Interval forecasts of weekly incident and cumulative COVID-19 mortality in the United States: A comparison of combining methods
Authors: Taylor Kathryn S. , Taylor James W. 
Published: March 2022

BackgroundA combined forecast from multiple models is typically more accurate than an individual forecast, but there are few examples of studies of combining in infectious disease forecasting. We investigated the accuracy of different ways of combining interval forecasts of weekly incident and cumulative coronavirus disease-2019 (COVID-19) mortality.MethodsWe considered weekly interval forecasts, for 1- to 4-week prediction horizons, with out-of-sample periods of approximately 18 months ending on 8 January 2022, for multiple locations in the United States, using data from the COVID-19 Forecast Hub. Our comparison involved simple and more complex combining methods, including methods that involve trimming outliers or performance-based weights. Prediction accuracy was evaluated using interval scores, weighted interval scores, skill scores, ranks, and reliability diagrams.ResultsThe weighted inverse score and median combining methods performed best for forecasts of incident deaths. Overall, the leading inverse score method was 12% better than the mean benchmark method in forecasting the 95% interval and, considering all interval forecasts, the median was 7% better than the mean. Overall, the median was the most accurate method for forecasts of cumulative deaths. Compared to the mean, the median’s accuracy was 65% better in forecasting the 95% interval, and 43% better considering all interval forecasts. For all combining methods except the median, combining forecasts from only compartmental models produced better forecasts than combining forecasts from all models.ConclusionsCombining forecasts can improve the contribution of probabilistic forecasting to health policy decision making during epidemics. The relative performance of combining methods depends on the extent of outliers and the type of models in the combination. The median combination has the advantage of being robust to outlying forecasts. Our results support the Hub’s use of the median and we recommend further investigation into the use of weighted methods.
A LEI DO GOVERNO DIGITAL NO BRASIL: ANÁLISE DAS CONTRIBUIÇÕES À TRANSPARÊNCIA PÚBLICA E À CONCRETIZAÇÃO DO EXERCÍCIO DO CONTROLE SOCIAL
Authors: Tavares André Afonso , Müller Bitencourt Caroline , Da Silva Cristóvam José Sérgio 
Published: March 2022

Contextualização do tema: as transformações experimentadas pela sociedade por meio do incremento da tecnologia, em especial, a partir da invenção da rede mundial de computadores, a Internet, são sentidas e vivenciadashá algum tempo por todos.Objetivos: Busca-se com a presente pesquisa investigar quais são as contribuições legais trazidas pela Lei Geral de Dados - Lei n. 14.129/21 para a concretização do exercício do controle social, por meio do aumento do acesso à informação e da transparência pública no Brasil.Metodologia: Utiliza como técnica de investigação a análise bibliográfica teórico-conceitual, que implica considerações da doutrina e da legislação pertinente. Como método científico propugna pela realização de uma revisão no entorno da seguinte hipótese: que 14.129/21 avança no caminho da transparência e controle social, na medida que se preocupa com a comunicação. Resultados: como conclusão, verificou-se que, ao passo que trouxe maiores regulamentações à transparência pública ativa e à abertura das bases de dados governamentais, no âmbito digital, trouxe avanços normativos importantes para a implementação do governo digital como plataforma para o controle social, além de relevantes instrumentos à inovação, tais como os laboratórios de inovação e redes de conhecimento, preocupando-se com a comunicação como pressuposto para a transparência.
PANORAMA GENERAL DEL DERECHO MEDIOAMBIENTAL EN NICARAGUA
Authors: Navarro Karlos 
Published: March 2022

Contextualização do tema: en este artículo se aborda el marco constitucional del derecho ambiental en la Constitución de la Republica de Nicaragua de 1987, y los tratados internacionales firmados por Nicaragua en materia de medio ambiente entre ellos los relacionados con la contaminación, biodiversidad, cambio climático, vida silvestre y humedales. Asimismo, se estudia la jurisprudencia en materia del medio ambiente dictada por la Corte Suprema de Justicia de Nicaragua, relacionada con temas como la Concesión de Recursos Naturales, permiso de pesca y de explotación forestal. Objetivos: analiza el panorama general del derecho medioambiental en Nicaragua.Metodologia: para el desarrollo de la investigación, la metodología utilizada en la Fase de Investigación fue inductiva, se utilizó como técnica la revisión de la literatura y los resultados se expresaron según la base lógica inductiva.Resultados: se concluyó que la Constitución Política de Nicaragua de 1987, y sus reformas, ha estado influenciada por las corrientes ambientalistas nacionales y extranjeras, particularmente conferencias o cónclaves mundiales.
Incidence Trends of Inflammatory Bowel Disease in a Southern European Country: A Mirror of the Western World?
Authors: Santiago Mafalda , Stocker Francisco , Ministro Paula , Gonçalves Raquel , Carvalho Diana , Portela Francisco , Correia Luís , Lago Paula , Trindade Eunice , Dias Cláudia Camila , Magro Fernando 
Published: March 2022

INTRODUCTION:
Inflammatory bowel disease (IBD) affects people from all age categories worldwide. Although the incidence of the disease is stabilizing or decreasing in most Western world countries, its prevalence is still increasing because of the rise in life expectancy and better disease management. This work intends to identify the trends related to IBD incidence nationwide, analyzing regional, sex, and age distributions.

METHODS:
Data were provided by the Portuguese Shared Services of the Ministry of Health. This study consisted of a retrospective analysis of all first consultations coded for “Chronic enteritis/ulcerative colitis” (D94) in a primary healthcare setting, between 2017 and 2020, in Portugal. The primary outcome measure was the IBD incidence rate per 100,000 inhabitants. We also calculated the incidence rate per person-year and forecasted incidence until 2024.

RESULTS:
Between 2017 and 2019, the incidence rate of IBD in Portugal decreased from 54.9 to 48.6 per 100,000 inhabitants. The average incidence was 20 new cases of IBD per 1,000 person-year. It was predicted that, in December 2023, IBD incidence would reach 305.4 new cases (95% Prediction Interval 156.6–454.3), a similar result to the values forecasted for December 2021 (305.4, 95% Prediction Interval 197.3–413.6).

DISCUSSION:
The incidence of IBD slightly declined from 2017 to 2019, and it is posed to stabilize in the future. The presented data are of the utmost importance for the characterization of IBD in Southern European countries and the establishment of future health policies in the setting of compounding prevalence in the Western world.
Low volume bowel preparation is associated with reduced time to colonoscopy in hospitalized patients: a propensity matched analysis
Authors: Sun Christopher L.F. , Li Darrick K. , Zenteno Ana Cecilia , Bravard Marjory A. , Carolan Peter , Daily Bethany , Elamin Sami , Ha Jasmine , Moore Amber , Safavi Kyan , Yun Brian J. , Dunn Peter , Levi Retsef , Richter James M. 
Published: March 2022

Abstract

Introduction:
Delays in inpatient colonoscopy are commonly caused by inadequate bowel preparation and result in increased hospital length of stay (LOS) and healthcare costs. Low volume bowel preparation (LV-BP; sodium sulfate, potassium sulfate, and magnesium sulfate) has been shown to improve outpatient bowel preparation quality compared to standard high volume bowel preparations (HV-BP; polyethylene glycol). However, its efficacy in hospitalized patients has not been well-studied. We assessed the impact of LV-BP on time to colonoscopy, hospital LOS, and bowel preparation quality among inpatients.

Methods:
We performed a propensity score matched (PSM) analysis of adult inpatients undergoing colonoscopy who received either LV- or HV-BP prior to colonoscopy at a quaternary academic medical center. Multivariate regression models with feature selection were developed to assess the association between LV-BP and study outcomes.

Results:
Among 1,807 inpatients included in the study, 293 and 1,514 patients received LV- and HV-BP, respectively. Among the PSM population, LV-BP was associated with shorter time to colonoscopy (β: -0.43 [95% CI: -0.56-(-0.30)] while having similar odds of adequate preparation (odds ratio: 1.02 [95% CI: 0.71-1.46]; P=0.92). LV-BP was also significantly associated with decreased hospital LOS among elderly patients (age ≥75 years), patients with chronic kidney disease, and patients that were hospitalized with gastrointestinal bleeding.

Discussion:
LV-BP is associated with decreased time to colonoscopy in hospitalized patients. Elderly inpatients, inpatients with chronic kidney disease, and inpatients with gastrointestinal bleeding may particularly benefit from LV-BP. Prospective studies are needed to further establish the role of LV-BP for inpatient colonoscopies.
A Thermodynamical Description of Third Grade Fluid Mixtures
Authors: Gorgone Matteo , Rogolino Patrizia 
Published: March 2022

Abstract
A complete thermodynamical analysis for a non-reacting binary mixture exhibiting the features of a third grade fluid is analyzed. The constitutive functions are allowed to depend on the mass density of the mixture and the concentration of one of the constituents, together with their first and second order gradients, on the specific internal energy of the mixture with its first order gradient, and on the symmetric part of the gradient of barycentric velocity. Compatibility with the second law of thermodynamics is investigated by applying the extended Liu procedure. An explicit solution of the set of thermodynamic restrictions is obtained by postulating a suitable form of the constitutive relations for the diffusional mass flux, the heat flux, and the Cauchy stress tensor. Taking a first order expansion in the gradients of the specific entropy, the expression of the entropy flux is determined. It includes an additional contribution due to non-local effects.