bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of health information of Nepalese labour migrants
Authors: Karkee Rajendra , Gurung Minani , Poudel Lisasha , Baral Chiranjivi , Adhikary Pratik , KC Radheshyam Krishan , Gurung Sundip , Gajdadziev Vasil , Duigan Patrick , Inkochasan Montira , Wickramage Kolitha Prabhash , Gurung Ganesh 
Published: January 2022

Abstract
IntroductionThe monitoring and improvementof the health of labour migrants (LMs) require sufficient health data to be recorded and managed. In this context, this study was conducted to understand the management of health information of Nepalese Labour Migrants (NLMs).MethodsThis is an explorative qualitative study. Stakeholders involved directly or indirectly in maintaining the health data of NLMs were first mapped, physically visited, and any documents or information was collected. Then, sixteen key informant interviews were conducted among these stakeholders related to labor migrants' health information management and challenges. A checklist extracted information from the interviews, and thematic analysis was carried out to summarize the challenges.ResultsGovernment agencies, non-governmental organizations, and Government approved private medical centers are involved in generating and maintaining the health data of NLMs.TheForeign Employment Board (FEB) records deaths and disabilities of NLMs while at work abroad and maintains an online portal of the Foreign Employment Information Management System (FEMIS) to collect and report migration-related data. Health assessment of NLMs is a mandatory procedure before departure, which is done through the government-approved pre-departure private medical assessment centers. The health records from these assessment centers are first recorded in paper-based form and then entered into an online electronic form to be stored by the Department of Foreign Employment (DoFE). The filled-up paper forms are sent to District Health Offices, which further report the data to the Department of Health Services (DoHS), Ministry of Health and Population (MoHP) and associated governmental infectious diseases centers. However, there is no formal health assessment of NLMs upon arrival to Nepal. Key informants raised various issues and concerns in maintaining health records of NLMs, which were grouped into three themes: lack of interest to develop a unified online system; need of competent human resources and equipment; and inclusion of various health indicators.ConclusionThe FEB and government-approved private assessment centers are the main stakeholders in keeping the health records of NLMs.Health records of NLMs have not been systematically kept in one database and shared with governmental health agencies. It is necessary to keep health records electronically in one database with relevant health indicators on departing and arriving NLMs.
Downregulation of RRS1 Inhibits Proliferation, Migration, And Epithelial-Mesenchymal Transition In Hepatocellular Carcinoma
Authors: Li Zhi , Wang Jitao , Liu Chengyu , Li Jinlong , Zhang Xiaochong , Zhao Xiaoling , Zhang Kunpeng , Zhen Zhongguang , Liu Dengxiang , Liao Yong 
Published: January 2022

Abstract
Background: Regulator of ribosome rynthesis 1 (RRS1) is an important nuclear protein involved in the biogenesis of ribosomes, and its relationship with a variety of cancers is confirmed by several studies. However, the underlying mechanism of RRS1-related carcinogenesis remains largely elusive.Methods: In this study, we aimed to investigated the role of RRS1 in hepatocellular carcinoma (HCC) by detecting the expression level of RRS1 in HCC tissues and para-carcinoma tissues and its effect on the proliferation, migration and epithelial-mesenchymal transition of HCC. Results: Compared with para-carcinoma tissues, the expression of RRS1 was significantly higher in HCC tissues, which is associated with the poor prognosis for HCC patients. In addition, knockdown RRS1 in HCC cell lines inhibited proliferation, migration and epithelial-mesenchymal transition (EMT). Conclusions: Our results indicated that RRS1 played an important role in proliferation, migration and EMT process of HCC. Hence, RRS1 might emerge as a promising therapeutic target for HCC.
DFT analysis of valproic acid adsorption onto Al12/B12-N12/P12 nanocages with solvent effects
Authors: Al-Otaibi Jamelah S , Mary Y.Sheena , Mary Y.Shyma 
Published: January 2022

Abstract
Using density functional theory, the adsorption of valproic acid onto the surface of fullerene-like nanocages was investigated. Valproic acid interact the nanocages through the carboxylic group with energies of -144.14, -109.71, -105.22 and -84.96 kcal/mol. The FMOs energy levels were considerably altered upon adsorption, resulting in a reduction in energy gap and increase in electrical conductivity. This suggests that nanocages could be used as sensors as well as options for drug administration in biological systems. Solvation effects in water are also reported.
A CRISPR-based ultrasensitive assay redefines “undetectable” SARS-CoV-2 antibodies in kidney transplant recipients after COVID-19 vaccination
Authors: Tang Yanan , Song Turun , Gao Lu , Yin Saifu , Ma Min , Tan Yun , Wu Lijuan , Lin Tao , Li Feng 
Published: January 2022

Abstract
An ultrasensitive assay for the detection of antibodies to SARS-CoV-2 is critically needed for evaluating the adaptive humoral immune response and infection rates in immunocompromised subpopulations. Here, we report an Ultrasensitive CRISPR-based Antibody Detection (UCAD) assay that translates the detection of serum antibodies against the receptor binding domain (RBD) of SARS-CoV-2 spike protein into CRISPR-based nucleic acid testing in a homogeneous solution and is thus 10,000 times more sensitive than the commercial immunoassay. The UCAD assay, which has been validated with 65 clinical anti-RBD-positive and 72 anti-RBD-negative sera collected from the general population, achieves 100% sensitivity and 97.2% specificity. We finally deployed UCAD to evaluate the levels of serum anti-RBD IgG and IgM in a cohort of 85 vaccinated kidney transplant recipients (KTRs), an especially vulnerable patient population with reported seroconversion rates of only 4-48%. Among the 85 vaccinated KTRs, UCAD successfully identified 68 seroconversion positive sera that were previously determined to contain “undetectable” levels of anti-SARS-CoV-2 using a clinical chemiluminescent immunoassay (CLIA) and has revealed significant differences in the levels of plasmablasts, type-2 T helper (Th2) cells, and type-17 T helper (Th17) cells between the UCAD-identified seroconversion positive and negative groups. As UCAD is a solution-based ultrasensitive assay that does not require specialized equipment or tedious operational and washing steps, we anticipate that it will find wide applications for clinical uses in both centralized laboratories and point-of-care settings.
Pattern and determinants of contraceptive use among the Muslim women in Wajir and Lamu counties in Kenya: A cross-sectional study
Authors: Abdi Batula , Okal Jerry , Serour Gamal , Were Vincent , Temmerman Marleen , Gichangi Peter 
Published: January 2022

Abstract
Improving access to family planning (FP) is associated with positive health benefits that includes averting nearly a third of all maternal deaths and 10% of childhood deaths. Kenya has made great strides in improving access to family planning services. However, amid this considerable progress, regional variation has been noted. MethodsWe conducted a cross-sectional study that involved 663 Muslim women of reproductive age (15-49 years) from Wajir and Lamu counties in Kenya between March and October 2018. Eligible women were interviewed using a semi-structured questionnaire containing socio-demographic information and history of family planning use. Simple and multiple logistic regression were used to identify determinants of family planning use. The results were presented as Crude Odds Ratio crude (COR) and Adjusted Odds Ratio (AOR) ratios at 95% confidence interval. A p-value of 0.05 was considered statistically significant.ResultsOf the 663 Muslim women of reproductive age consenting to participate in the study, 51.5%, n=342 and 48.5%, n=321 were from Lamu and Wajir County, respectively. The prevalence of women currently using contraceptive was 18.6 percent (n=123). In Lamu, the prevalence was 32.8%, while in Wajir, it was 3.4 percent.The determinants of current contraceptive use in Lamu include; marital status, age at marriage employment status, discussion with a partner on FP, acceptability of FP in Culture, and willingness to obtain information on FP. While in Wajir, determinants of current contraceptive use were education, Family planning allowed in Islam.ConclusionsOur study found moderately high use of contraceptives among Muslim women of reproductive age in Lamu county and very low contraceptive use among women in Wajir. There is need for family planning programs to address issues of male involvement in reproductive health given the patriarchal nature of the two communities. It is critical for the government to invest in women and girls education to enhance their ability to make informed decisions; particularly in Wajir where FP uptake is low with low education attainment. Further, our findings highlight the need for culturally appropriate messages and involvement of religious leaders to demystify the myths and misconception around family planning and Islam.
Effects of magma-generation and migration on the expansion and contraction history of the Moon.
Authors: U Kenyo , Hasumi Hiroki , Ogawa Masaki 
Published: January 2022

Abstract
Geological and geodetic observations of the Moon from spacecraft revealed that it expanded by a few km for the first several hundred million years and then contracted later. The period when the planet expanded most coincides with that when the mare volcanism of the Moon was active. Given the high initial temperature of the deep mantle inferred from the giant impact and mantle overturn hypotheses of the Moon, the observed early expansion is difficult to account for by thermal expansion only. To understand the observed radial change of the Moon, we numerically calculated the thermal evolution of a one-dimensional spherically symmetric mantle caused by transport of heat, mass, and incompatible heat-producing elements (HPEs) by migration of magma that is generated by internal heating. The mantle is assumed to be enriched in HPEs at its base in the initial condition. The calculated mantle expands for the first several hundred million years by melting of the deep mantle and upward migration of the generated magma to the uppermost mantle; the top of the partially molten region rises up to the depth level of around 300 km, shallow enough to generate mare basalts of the Moon. The migrating magma, however, extracts HPEs from the deep interior, and the planet then contracts gradually by cooling and solidification of the partially molten mantle. We obtained a thermal history that is consistent with the observed history of radial change of the Moon when the initial mid-mantle temperature \({T}_{M}\approx 1600 K\) and the initial ratio of the concentration of HPEs in the crust to that of the mantle \({F}_{crst}\le 12\). This initial state of the mantle inferred from its thermal history constrains the earliest evolution of the Moon dominated by the magma ocean and mantle overturn.
Comparison of the clinical features, viral shedding and immune response in vaccine breakthrough infection by the Omicron and Delta variants
Authors: Young Barnaby , Fong Siew-Wai , Chang Zi Wei , Tan Kai Sen , Rouers Angeline , Goh Yun Shan , Tay Douglas Jie Wen , Ong Sean W. X. , Hao Ying , Chua Siang Li , Chavatte Jean-Marc , Cui Lin , Tay Matthew , Lin Raymond Tzer Pin , Renia Laurent , Leo Yee-Sin , Chu Justin Jang Hann , Lye David , Ng Lisa Fong Poh 
Published: January 2022

Abstract
BackgroundOn 26 November 2021, the World Health Organization designated the B.1.1.529 lineage of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) as the fifth variant of concern, Omicron. Infections have quickly spread worldwide, but understanding of the viral dynamics and the cytokine and cellular immunological response during infection remain limited.MethodsDetailed patient-level data from 174 age-matched patients with sequence confirmed Omicron or Delta infection admitted to the National Centre for Infectious Diseases, Singapore were analyzed in an observational cohort study. Peripheral blood samples for measurement of SARS-CoV-2 immunological parameters were obtained from a subset. Respiratory samples were collected for viral cultures and correlated to corresponding PCR cycle threshold (Ct) values. ResultsOmicron and Delta variant infections in this hospitalized cohort were mild with only 3 (3%) and 14 (16%) developing pneumonia respectively. Omicron infections were more likely to present with sore throat (46.0 vs x23.0%, p=0.005). Neutrophil counts and C-reactive protein (CRP) were significantly lower among the Omicron cohort (Median neutrophil 2.95 [IQR 2.16 – 3.96] vs 4.60 [IQR 3.76 – 6.10] x 109/L , p<0.001; Median CRP 5.7 [IQR 2.0 – 10.0] vs 12.0 [IQR 6.1 – 22.0] mg/L, p<0.001). Trough polymerase chain reaction (PCR) cycle threshold (Ct) values were significantly higher with Omicron infection (17.6 [IQR 16.3 – 19.3] vs 14.9 [IQR 13.9 – 19.0], p=0.001). The pattern and rate of rise in Ct values was similar between Omicron and Delta. At the time of infection, Omicron infected patients had lower levels of pro-inflammatory cytokines Vaccine breakthrough infections with the Omicron variant had a low concentration of proinflammatory cytokines, chemokines, and growth factors at the acute phase of infection, but a more robust IFN-γ response. Less dysregulated immune cell profiles were also observed, including a lower immature neutrophil cell count in Omicron breakthrough casesConclusionsOmicron infections resulted in mild vaccine breakthrough illness in the majority of patients. Compared with Delta, Omicron infections were more frequently associated with upper respiratory tract infections, had lower viral loads, lower levels of pro-inflammatory cytokines and less dysregulated immune cell profiles.
Overlapping Group Screening for Detection of Gene-environment Interactions with Application to TCGA High-dimensional Survival Genomic Data
Authors: Wang Jie-Huei , Wang Kang-Hsin , Chen Yi-Hau 
Published: January 2022

Abstract
Background: In the context of biomedical and epidemiological research, gene-environment (G-E) interaction is of great significance to the etiology and progression of many complex diseases. In high-dimensional genetic data, two general models, marginal and joint models, are proposed to identify important interaction factors. Most existing approaches for identifying G-E interactions are limited owing to the lack of robustness to outliers/contamination in response and predictor data. In particular, right-censored survival outcomes make the associated feature screening even challenging. In this article, we utilize the overlapping group screening (OGS) approach to select important G-E interactions related to clinical survival outcomes by incorporating the gene pathway information under a joint modeling framework.Results: Simulation studies under various scenarios are carried out to compare the performances of our proposed method with some commonly used methods. In the real data applications, we use our proposed method to identify G-E interactions related to the clinical survival outcomes of patients with head and neck squamous cell carcinoma, esophageal carcinoma, and lung adenocarcinoma in The Cancer Genome Atlas clinical survival genetic data, and further establish corresponding survival prediction models. Both simulation and real data studies show that our method performs well and outperforms existing methods in the G-E interaction selection, effect estimation, and survival prediction accuracy.Conclusions: The OGS approach is useful for selecting important environmental factors, genes and G-E interactions in the ultra-high dimensional feature space. The prediction ability of OGS with the Lasso penalty is better than existing methods. The same idea of the OGS approach can apply to other outcome models, such as the proportional odds survival time model, the logistic regression model for binary outcomes, and the multinomial logistic regression model for multi-class outcomes.
Gene Profiling of SEC13, SMAD7, GHRL, Long Non-Coding RNA GHRLOS, HIF-1α In Gastric Cancer Patients
Authors: Hussein Neveen A. , Rashad Mona M. , Ibrahim Azza S. , Hussein Amr M. , Mohamed Hagar M. 
Published: January 2022

Abstract
Background: Even with considerable progress in cancer researches, gastric cancer is still one of the global health problems. Recognition of the differential expressed genes in GC is the most appropriate approach for establishing new diagnostic targets. This study evaluates SEC13, SMAD7, GHRL, lncRNA GHRLOS, HIF-1α genes profiling as well as HIF-1α protein level for GC.Methods: The expression of selected genes, serum HIF-1α and CEA protein levels were determined for 50 GC patients and 50 healthy controls by real-time RT-PCR, ELISA, and ELICA respectively. The sensitivities of these parameters as diagnostic biomarkers were evaluated.Results: SMAD7, HIF-1α expression, serum HIF-1α, and CEA level were significantly upregulated in GC patients as compared to the control group and had significant positive correlations between most of them. On the other hand, SEC13, GHRL, and LncRNA GHRLOS expression were significantly downregulated in GC patients and had significant positive correlations with each other. Significant negative correlations were observed between most of both groups. All studied parameters were associated with GC clinical stages except SMAD7 was associated with stage IV only and GHRL did not associate with tumor stages.Conclusions: All studied parameters may be promising biomarkers for the early diagnosis of GC. SMAD7, HIF-1α gene, and HIF-1α protein may be jointly implicated in cancer development and prognosis, while SEC13, GHRL, and lncRNA GHRLOS may act as tumor suppressors.
Detection and Parameter Estimation of Multicomponent LFM Signal based on Nonlinear Transformation under the Impulsive Noise
Authors: Li Li , Shi Xiaofei , He Mingyan 
Published: January 2022

Abstract
The linear frequency modulated (LFM) signal has been widely implemented in broadband wireless communications in high-speed vehicles, such as internet of vehicles(IoV), because of its excellent characteristic of long time interval and wide frequency band. In this paper, a novel method, which employs the fractional Fourier transform and the Tuneable-Sigmoid transform, is proposed to estimate parameters of multicomponent LFM signals in Internet of Vehicles(IoV) under the impulsive noise environment. For the optimization in the fractional Fourier domain, an algorithm based on peak searching is proposed. And for multicomponent signals, we further propose a signal separation technique in the fractional Fourier domain which can effectively suppress the interferences on the detection of the weak components brought by the stronger components, and estimate parameters of LFM signals. Moreover, boundedness and the complexity analysis of Tuneable-Sigmoid-FFRT to the noise are presented to evaluate the performance of the proposed method. In additional, the Cramér–Rao bound for parameter estimation is derived and computed in closed form, which shows that better performance has been achieved. Both theoretical analysis and simulations demonstrate the superior performances of the proposed approach over other existing methods.
Response Parameters that Control the Service, Safety and Collapse Performances of a 253 m Tall Concrete Core Wall Building in Istanbul
Authors: Budak Erhan , Sucuoglu Haluk , Celik Ozan Cem 
Published: January 2022

Abstract
Seismic performance of a 253 m tall reinforced concrete core wall building in Istanbul, designed according to performance-based seismic design principles, is assessed for determining the response parameters that control the serviceability, safety and collapse performance limit states. Serviceability performance is evaluated under the 50year wind and 43-year earthquake whereas safety performance is assessed under the 2475-year earthquake. Collapse performance is elaborated through incremental dynamic analysis. Our study revealed that the service performance is controlled by the maximum interstory drift limits specified for wind loads, and safety performance is controlled by the flexural steel strain limits of coupling beams. Collapse occurs in two consecutive stages: flexural collapse of coupling beams, followed by crushing of concrete at critical shear wall segments. Collapse spectra are defined for these two collapse limit states. Collapse spectra can be extrapolated from the 2475-year maximum considered earthquake (MCE) spectrum provided that the prevailing inelastic mechanisms are similar under the MCE and collapse ground motions. The building displays a significantly higher seismic performance at all performance levels, which is primarily attributed to the overstrength due to the limitation of axial stresses on vertical members under design earthquake load combination. The annual frequency of the mean earthquake ground motions that leads to incipient collapse is determined as 8·10 -5 , which is significantly lower than the annual frequency of 2475-year ground motions.
Primary Intraspinal Tumors in China: A Consecutive Surgical Series of 589 Patients
Authors: Si Meng , Cong Menglin , Wang Dandan , Hou Yong , Nie Lin , Ma Hecheng 
Published: January 2022

Abstract
Purpose: Primary intraspinal tumors are rare tumors of the central nervous system. There is a paucity of detailed clinical data on the tumors for neurosurgeons. The paper is to report the clinical characters of 589 patients with primary intraspinal tumors in China.Methods: Medical records of 589 patients with primary intraspinal tumor treated surgically with pathologic confirmation from January 2015 to December 2019 in our hospital were collected and reviewed. In each case, data about patient's age at surgery, sex, clinical presentation, anatomical location, vertebral levels and histological diagnosis were obtained and analyzed.Results: The entire cohort included 281 (47.7%) males and 308 (52.3%) females with a mean age of 48.1 years. Primary intraspinal tumors were most likely occurred on thoracic levels, counting 38.7%, compared with cervical 25.1% and lumbar 33.7%. 80.3% (472/589) of intraspinal tumors were intradural extramedullary, and 5.60% (33/589) were intramedullary, and 13.07% (77/589) were epidural. The pathological diagnoses included schwannoma (52.8%), meningioma (10.4%), cyst (8.0%), teratoma (24,4.1%), ependymoma (23,3.9%), and angioma (23,3.9%), and females had a higher incidence of meningiomas than males, with a male/female of 0.20. Pain, numbness, weakness, and sensory disturbances were most common presentations of the intraspinal tumor, which was determined partially by the vertebral level distribution and anatomical location.Conclusions: This large single-center clinical study adds new insights into the descriptive epidemiology and characters of primary intraspinal tumors by providing in-depth analyses of these tumors, which is of vital importance in planning studies on prevention, diagnosis, treatment, and prognosis of the tumors.