bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptions of the impact of a multidose human‐milk fortifier on human‐milk preparation practices in United States neonatal intensive care units: A survey of nutrition care team members
Authors: Gates Amy , Evans Heather V. , Gatto Alayne M. , Le Vin Jodee , Thornton Jessica L. , Langley Katina , Hodges Bethany S. , Valentine Christina 
Published: November 2022

AbstractBackgroundIn 2020, a multidose human‐milk fortifier (MDHMF) was designed to improve the process of human‐milk (HM) fortification. The bottle of MDHMF (5.5 oz, 163 ml) allows aseptic removal of HMF in a precise measure. This survey aimed to examine the experience of nutrition care team (NCT) members who used the MDHMF in a hospital setting.MethodsA survey link (Qualtrics XM) was sent to NCT leaders (N = 108) at hospitals who participated in an evaluation of the MDHMF from June 1, 2020, through April 30, 2021. The NCT leaders sent the survey to members at their prospective hospitals (n = 344). The investigators did not know the identities of the recipients of the survey and collected no identifying information on respondents. Respondents were asked to evaluate their experience with the MDHMF compared with their previous practice.ResultsThe majority of respondents (n = 63, 72%) reported that the MDHMF improved their HM preparation practices and was better than their previous practice for reducing the time to prepare (n = 33, 71.7%), ensuring the accuracy of fortified HM (n = 32, 69.6%), ensuring aseptic preparation (n = 24, 52.2%), reducing HM waste (n = 27, 58.7%), and being easy to use (n = 30, 65.2%). Those responsible for evaluating nutrition status answered that the MDHMF was the same for feeding tolerance (n = 41, 58.6%), weight gain (n = 47, 67.1%), head growth (n = 56, 81.2%), and length growth (n = 53, 76.8%).ConclusionUS neonatal intensive care unit NCT members perceived that the MDHMF resulted in improved HM preparation practices while maintaining growth and tolerance.
Antibiotic use in nonintubated children with bronchiolitis in the intensive care unit
Authors: Ortmann Laura A. , Nabower Aleisha , Cullimore Melissa L. , Kerns Ellen 
Published: November 2022

AbstractIntroductionAntibiotic use may shorten mechanical ventilation duration and length of stay for patients with bronchiolitis that require intubation. The goals of this study were to describe antibiotic use in previously healthy children with bronchiolitis admitted to the intensive care unit (ICU) for noninvasive respiratory support and to describe associations of early antibiotic use with clinical outcomes.MethodsThe Pediatric Health Information Systems database was queried for children <2 years of age without significant comorbidities admitted to the ICU for bronchiolitis. Children requiring mechanical ventilation on the first ICU day were excluded. Two groups were analyzed: those patients receiving antibiotics on the first day of their ICU stay (early antibiotics), and those receiving no antibiotics on their first ICU day (no antibiotics). Primary outcome was the length of ICU stay.ResultsA total of 11,029 admissions met criteria, 2522 (22.9%) in the early antibiotic group, and 8507 (77.1%) in the no antibiotic group. The use of early antibiotics varied by center from 10% to 54%. In multivariate analysis, the early antibiotic group had similar ICU length of stay compared to the no antibiotic group (relative risk, RR [95% confidence interval, CI] 1.01 [0.98–1.05]). For patients on noninvasive ventilation, the first ICU day early antibiotics did not impact ICU length of stay (RR [95% CI] 0.97 [0.92–1.02]) or need for intubation (RR [95% CI] 1.11 [0.77–1.58]).ConclusionEarly antibiotic use was common with significant variation between centers. Early antibiotic use was not associated with improved clinical outcomes in children admitted to the ICU for noninvasive respiratory support for bronchiolitis.
Hesperetin ameliorates ischemia/hypoxia‐induced myocardium injury via inhibition of oxidative stress, apoptosis, and regulation of Ca2+ homeostasis
Authors: Liu Panpan , Chen Jian , Qi Jiaying , Liu Miaomiao , Zhang Muqing , Xue Yucong , Li Li , Liu Yanshuang , Shi Jing , Zhang Yixin , Chu Li 
Published: November 2022

AbstractIschemia/hypoxia (I/H)‐induced myocardial injury has a large burden worldwide. Hesperetin (HSP) has a cardioprotective effect, but the molecular mechanism underlying this is not clearly established. Here, we focused on the protective mechanisms of HSP against I/H‐induced myocardium injury. H9c2 cardiomyocytes were challenged with CoCl2 for 22 h to imitate hypoxia after treatment groups received HSP for 4 h. The viability of H9c2 cardiomyocytes was evaluated, and cardiac function indices, reactive oxygen species, apoptosis, mitochondrial membrane potential (MMP), and intracellular Ca2+ concentration ([Ca2+]i) were measured. L‐type Ca2+ current (ICa‐L), myocardial contraction, and Ca2+ transients in isolated ventricular myocytes were also recorded. We found that HSP significantly increased the cell viability, and MMP while significantly decreasing cardiac impairment, oxidative stress, apoptosis, and [Ca2+]i caused by CoCl2. Furthermore, HSP markedly attenuated ICa‐L, myocardial contraction, and Ca2+ transients in a concentration‐dependent manner. Our findings suggest a protective mechanism of HSP on I/H‐induced myocardium injury by restoring oxidative balance, inhibiting apoptosis, improving mitochondrial function, and reducing Ca2+ influx via L‐type Ca2+ channels (LTCCs). These data provide a new direction for HSP applied research as a LTCC inhibitor against I/H‐induced myocardium injury.
A stretch hood as a mean to facilitate safe indoor transport of palletized goods
Authors: Roman Jannes , Verschueren Gilles , Nica Ward , Slaets Peter , Juwet Marc 
Published: November 2022

AbstractInertial forces occur during the internal transport of a pallet with palletized goods. Therefore, transport packaging must guarantee that the goods resist these destructive forces. The effectiveness of a stretch hood as a transport package is researched in this study.

Firstly, it is determined if a stretch hood can be applied accordingly without it being damaged by the forks of a forklift or an AGV when being picked up.
Secondly, the resistance to horizontal inertial forces during the internal transport of a stretch hooded pallet load is researched.
The performed study shows that many parameters influence the sleeving process. A well‐chosen stretch hood, applied with the correct machine settings, can guarantee both minimum requirements for internal transport.
Evaluating the risk of fish stranding due to hydropeaking in a large continental river
Authors: Glowa Sarah E. , Watkinson Douglas A. , Jardine Timothy D. , Enders Eva C. 
Published: November 2022

AbstractWith the continuous development of hydropower on a global scale, stranding of freshwater fishes is of growing concern, and an understanding of the mechanisms and variables affecting fish stranding in hydropeaking rivers is urgently needed. In particular, a methodology is required to identify the magnitude and timing at which fish stranding occurs in relation to environmental conditions. Here, we studied fish stranding in three reaches downstream of a hydropeaking generation station in the Saskatchewan River, Saskatchewan, Canada, using an innovative remote photography approach with 45 trail cameras and traditional transect monitoring, conducting 323 transects. We observed that juvenile sport and commercial fish species are stranding at a higher proportion than small bodied fish species. The remote photography approach provided more precise fish stranding timing and associated the environmental and physical conditions with a given stranding event, but captured fewer fish and only rarely allowed species identification. The comparison of the two methodologies resulted in similar stranded fish densities, but the remote photography allowed for continuous observations whereas the transect monitoring was limited by the observer availability in the field. Remote photography allowed for additional information on the scavenging of stranded fish, with scavenging occurring on average within 240 minutes of the fish being stranded. The probability of fish stranding increased significantly with increasing water temperature and substrate particle size resulted in greater stranding on finer substrates. Our findings have important implications for hydroelectric flow management by introducing an innovative, standardized method to study the effects of hydropeaking events on fish stranding that can be applied to increase our understanding of the impacts of hydropeaking on fish communities.
FluorMango, an RNA‐Based Fluorogenic Biosensor for the Direct and Specific Detection of Fluoride
Authors: Husser Claire , Vuilleumier Stéphane , Ryckelynck Michael 
Published: November 2022

AbstractNucleic acids are not only essential actors of cell life but also extremely appealing molecular objects in the development of synthetic molecules for biotechnological application, such as biosensors to report on the presence and concentration of a target ligand by emission of a measurable signal. In this work, FluorMango, a fluorogenic ribonucleic acid (RNA)‐based biosensor specific for fluoride is introduced. The molecule consists of two RNA aptamer modules, a fluoride‐specific sensor derived from the crcB riboswitch which changes its structure upon interaction with the target ion, and the light‐up RNA Mango‐III that emits fluorescence when complexed with a fluorogen. The two modules are connected by an optimized communication module identified by ultrahigh‐throughput screening, which results in extremely high fluorescence of FluorMango in the presence of fluoride, and background fluorescence in its absence. The value and efficiency of this biosensor by direct monitoring of defluorinase activity in living bacterial cells is illustrated, and the use of this new tool in future screening campaigns aiming at discovering new defluorinase activities is discussed.
Stories from Students Building Sustainability Through Transfer of Leadership
Authors: Gautam Saurav , Aman K. C. , Ojha Rabin , Parajuli Gaurav 
Published: November 2022

AbstractDedicated to designing and organizing student-centered work, we highlight the Geomatics Engineering Students’ Association of Nepal (GESAN)’s collaborative effort to create training, internship, and job opportunities for the student members and alumni and with local institutions. Through putting into play a cycle of leadership, chapter activities find a sustainable way to continue to support SDG 8 Decent Work and Economic Growth and SDG 9 Industry, Innovation, and Infrastructure by preparing students to navigate newer applications of geospatial technology and tools. This work extends beyond campus and into the local community where we have trained secondary school students in map literacy – planting seeds of future leadership.
The Ecosystem Where YouthMappers Live and Thrive
Authors: Carney-Nedelman Dara , Clark Courtney 
Published: November 2022

AbstractYouthMappers live and thrive in an ecosystem of university chapters, organizers, sponsors, ambassadors, and partners. This system places youth at the center and is designed as an empowering network, which ultimately advances partnerships for the goals, in line with SDG 17. But because we don’t just build maps, we build mappers- the result of this ecosystem also expands the capacity for students to advance to decent work and contribute to the economic growth in their careers and of their countries. We present here some of the voices of students, alumni, staff, and partners to describe this enabling ecosystem from their own perspectives.
Cultural Seascapes in the ‘Sea of Calms’ and La Restinga Coast
Authors: De la Cruz-Modino Raquel , Piñeiro-Corbeira Cristina , Aswani Shankar , González-Cruz Carla , Domínguez David , Ordóñez García Paula , Santana-Talavera Agustín , Pascual-Fernández José 
Published: November 2022

AbstractEl Hierro has been characterized by the balance between human development and environmental sustainability. The island was historically far from the mass tourism developments dominant on the other Canary Islands. Tourism accommodations in El Hierro are few compared to more developed coastal areas in the Archipelago, and recreational activities are mainly linked to cultural and natural sites and resources. This chapter focuses on La Restinga fishing village and its coasts, where the ‘Sea of Calms’ and one multiple-use Marine Reserve (MR) are located, both of which became popular over the last decade. The tourist development experience has promoted a new way of looking at the sea and conceptualizing its habitats and populations. In 2014, after the submarine volcano eruption occurred in 2011, we estimated that at least 25,391 dives had been carried out in the diving spots established by the MR and other diving sites close to La Restinga. Despite the difficulties experienced after the volcano eruption, a unique imaginaire has been consolidated, thanks to the image of the island's exclusive nature and iconic elements. In addition, the rapid recovery of the destination is an excellent example of how the tourism system can adapt and incorporate unexpected events such as volcanic eruptions.
Human Occupation of a Small Volcanic Island
Authors: Martín Fernández Carlos S. 
Published: November 2022

AbstractEl Hierro has had an evolution in terms of its population in close relation to a series of historical, economic and social transformations that have left an important mark on the landscape. In general terms, we could affirm that the evolution and distribution of the population has been conditioned by economic cycles and modes of production, which have worked in accordance with the interest of local and regional elites.
Opening Up New Spaces for Action: Challenges of Participatory Action Research for Preschool Practice Transformation in an Introductory Unit for Immigrant Children
Authors: Åkerblom Annika 
Published: November 2022

AbstractThe aim of this chapter is to reflect on and problematise some of the collective processes that emerged in a 3-year participatory project. The project, situated in a linguistically and culturally diverse neighbourhood of a major Swedish city, was carried out between 2017 and 2019. The overall aim was to, in collaboration with participants, explore the conditions for early childhood education in a migrating world by identifying the challenges facing preschool institutions. An additional aim was to develop preschool practice through reflection and action. The project started out in an introductory unit for immigrant children aged 3–5 years who spoke little or no Swedish upon entering the unit; then, as the project went on, the whole preschool was gradually included in actions carried out in collaboration. Some of the spaces for action that opened up for the children, educators, and preschool managers are addressed in the chapter. Challenges involved, among other things, differences in the possibility to take part in action research processes among families involved in asylum processes and what space for action the preschool educators were actually afforded in the project.
Interprofessional Dialogue and the Importance of Contextualising Children’s Participation: A Collaboration Between Different Disciplines Around New Technology
Authors: Lagerlöf Pernilla 
Published: November 2022

AbstractThe MIROR Project (2010–2013) was a large-scale international research project financed by the EU, involving various researchers from six countries. It dealt with the development of an adaptive system (artificial intelligence, AI) for music learning and teaching in the context of early childhood music education. The project was based on a spiral design approach, involving coupled interactions between the technical partners and the research partners (from the disciplines of psychology and pedagogy/education). It raised methodological challenges concerning how the experiments and technology were designed, as they did not relate to Swedish preschool tradition, which will serve here as the contextualised case from which more general issues will be discussed. Different ethical issues were also faced in regard to how the research was planned, and stemming from the fact that there were commercial interests involved.
Artificial intelligence in support of the circular economy: ethical considerations and a path forward
Authors: Roberts Huw , Zhang Joyce , Bariach Ben , Cowls Josh , Gilburt Ben , Juneja Prathm , Tsamados Andreas , Ziosi Marta , Taddeo Mariarosaria , Floridi Luciano 
Published: November 2022

AbstractThe world’s current model for economic development is unsustainable. It encourages high levels of resource extraction, consumption, and waste that undermine positive environmental outcomes. Transitioning to a circular economy (CE) model of development has been proposed as a sustainable alternative. Artificial intelligence (AI) is a crucial enabler for CE. It can aid in designing robust and sustainable products, facilitate new circular business models, and support the broader infrastructures needed to scale circularity. However, to date, considerations of the ethical implications of using AI to achieve a transition to CE have been limited. This article addresses this gap. It outlines how AI is and can be used to transition towards CE, analyzes the ethical risks associated with using AI for this purpose, and supports some recommendations to policymakers and industry on how to minimise these risks.
Myomodulation with Facial Fillers: A Comprehensive Technical Guide and Retrospective Case Series
Authors: Coimbra Daniel Dal’Asta , Stefanello Betina 
Published: November 2022

Abstract
Background
Placement of fillers in close proximity to the mimetic or sphincter muscles of the face appears to enhance or suppress muscle action in a relatively predictable way.

Methods
From June 2016 to June 2021, patients who underwent the first author’s technique of myomodulation with dermal fillers to address aesthetic concerns or to manage facial spasms or synkinesis were evaluated in a retrospective case series. Additionally, the authors provide a technical guide for a whole-face approach to treatment with fillers and a conceptual map for treatment of each facial subunit with a focus on myomodulation.

Results
A total of 1352 patients (1108 women, 244 men; mean age, 51 years) underwent at least 1 treatment session during the 5-year study period. The treatment patterns of the study population and details of 2 representative cases are presented.

Conclusions
Although not well understood mechanistically, myomodulation with injectable fillers shows promise for significant and reliable results of facial rejuvenation.

Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Injury by knife crime amongst children is associated with socioeconomic deprivation: an observational study
Authors: Reilly John-Joe , Naumann David N. , Morris Louise , Blackburn Lauren , Brooks Adam 
Published: November 2022

Abstract
Purpose
Children who live in areas of socioeconomic deprivation may be at higher risk of being victims of violent crime such as knife wounds. The current study investigated whether socioeconomic disparity was associated with higher risk of knife crime.

Methods
An observational study included patients aged ≤ 17 years at a UK Major Trauma Centre injured by knife trauma from 2016 to 2022. Indices of deprivation were recorded according to the zip code of residence and compared with those of all of England. These included Index of Multiple Deprivation (IMD); income; employment; education and skills; health and disability; crime; barriers to housing and services; living environment; and Income Deprivation Affecting Children Index (IDACI).

Results
There were 139 patients (96% male) with median age of 16 years. When compared with the whole of England, patients had worse indices of IMD (p = 0.021); income (p < 0.001); employment (p < 0.001); education and skills (p < 0.001); health and disability; and IDACI (p < 0.001). There were no significant differences in indices of crime, barriers to housing and services or living environment.

Conclusions
Paediatric knife injury was associated with poor socioeconomic status in multiple domains. Focussed efforts to address socioeconomic disparities should be a priority as a public health measure for vulnerable children.
The RonchAP® palatinal device: A conservative approach in treating obstructive sleep apnea syndrome—a randomized, controlled study
Authors: Lembacher Sophie , Gantner Sophia , Uhl Bernd , Holzer Martin , Patscheider Martin , Hempel John-Martin 
Published: November 2022

Abstract
Purpose
The aim of the present study was to assess the efficacy of the Ronch®AP palatal device in treating patients with moderate and severe forms of obstructive sleep apnea syndrome.

Methods
In a randomized controlled trial 22 patients were examined with the Ronch®AP palatal device after 4 weeks of usage. Their results were compared to a control group of 30 patients who did not receive any treatment during this time. All patients included did not tolerate CPAP therapy. Among other parameters the apnea–hypopnea index (AHI) was measured using nocturnal cardiorespiratory polysomnography. Daytime sleepiness was assessed using Epworth Sleepiness Scale. Pittsburgh Sleep Quality Index was used to analyze sleep quality.

Results
Using the Ronch®AP palatal device AHI was reduced from an average of 35.34 ± 14.9/h to 19.18 ± 14.93/h, whereas the control group only showed a minimal mean reduction from 31.32 ± 12.76/h to 29.37 ± 17.11/h. The difference in reduction between the two randomized groups was highly significant (d = − 14.2, 95% CI 5.9–22.6, t = 3.4, df = 49.9, p = 0.001). Epworth Sleepiness Scale score was lowered from 9.18 ± 4.73 to 7.82 ± 4.14 on average and sleep quality improved by − 1.91 ± 2.31. Both changes were also statistically relevant (p < 0.005).

Conclusions
The Ronch®AP device is an effective alternative treatment option for patients suffering from moderate and severe forms of obstructive sleep apnea syndrome and not tolerating CPAP therapy.

Trial registration number
407-16 with approval from the local ethical committee (Ethikkommission der Medizinischen Fakultät der LMU München).
New technology can benefit established middle ear implant users: Samba 2 vs previous models of audio processors for Vibrant Soundbridge
Authors: Ratuszniak Anna , Lorens Artur , Obrycka Anita , Witkowska Justyna , Skarzynski Henryk , Skarzynski Piotr Henryk 
Published: November 2022

Abstract
Introduction
The Vibrant Soundbridge (VSB) is a semi-implantable hearing aid for patients with various types of hearing loss and has been available for over 25 years. Recently, new audio processors with advanced signal processing, noise reduction, and multi-microphone technology have appeared. The aim of this study is to compare the benefits of using the newest Samba 2 processor to the previous generation processors in a group of experienced VSB users.

Methods
There were 22 experienced VSB users (mean time of using VSB was 9 years, SD = 2) who had their processor (D404 or Amadé) upgraded to the newest model (Samba 2). The mean age of the subjects was 56 years (SD = 20). Assessments were made by free-field audiometry, speech reception in quiet and noise, and Patient-Reported Outcome Measures (PROMs).

Results
Hearing tests in free field showed statistically significant improvements in hearing sensitivity and speech discrimination in quiet and noise with the Samba 2 audio processor compared to the earlier technology. PROMs confirmed the benefits of using the newest audio processor and there was more satisfaction in terms of usability.

Conclusions
Access to modern technology for VSB patients provides measurable benefits.