bluuebunny/crossref_metadata_2025_split huggingface dataset:
Einflussfaktoren auf die Krankenhausbewertungen im Internet in NRW am
Beispiel von Klinikbewertungen.de und Google.de
Authors: Kreuzenbeck Cordula Charlotte Josefine , Heinz André 
Published: September 2022

Zusammenfassung
Ziel der Studie Klinikgeschäftsführer sehen sich
häufig mit den negativen Bewertungen im Internet konfrontiert.
Für die Online-Bewertung von Krankenhäusern stehen keine
aktuellen Daten zur Verfügung, mit denen ermittelt werden kann, welche
Faktoren die Bewertungen neben der tatsächlichen Qualität in
Krankenhäusern beeinflussen. Das Ziel dieser Studie war die Erhebung der
im Internet geäußerten Zufriedenheit zusammen mit den Grunddaten
der Krankenhäuser wie sie über den Qualitätsbericht
veröffentlicht werden. Hierdurch sollten Faktoren ermittelt werden, die
unabhängig von der Qualität in Krankenhäusern das
Bewertungsbild im Internet prägen.
Methodik Zunächst wurden die Daten zu 364 Krankenhäusern
in NRW aus den gesetzlichen Qualitätsberichten und den
Bewertungsplattformen Klinikbewertungen.de und Google.de zusammengetragen.
Eingeschlossen wurden nur Krankenhäuser mit mindestens drei somatischen,
bettenführenden Abteilungen zu denen aktuelle Daten im
Qualitätsbericht verfügbar waren und beide Bewertungsplattformen
Bewertungen enthielten. Mittels deskriptiver Methoden und einer schrittweise
ausschließenden, multiplen linearen Regression wurden die Daten der
Krankenhäuser analysiert und signifikante Einflussfaktoren
identifiziert. Es wurde ein Signifikanzniveau von 5% zugrunde
gelegt.
Ergebnisse Es wurden 190 Krankenhäuser in die Analyse
eingeschlossen. Davon 71% in freigemeinnütziger, 16% in
öffentlicher und 13% privater Trägerschaft. Die
durchschnittliche Zufriedenheit auf den online-Plattformen über alle
Krankenhäuser betrug 66,82%. Einen signifikanten Einfluss auf
die online Bewertungen hatten nur der Anteil der Bewertungen im
Verhältnis zur stationären Fallzahl und die Facharztquote. Die
P-Werte lagen hier bei 0,0000 und 0,0072 respektive. Die Regression hatte ein
Bestimmtheitsmaß von 0,34 und war insgesamt zum angegeben alpha-Level
von 5% signifikant. Der größere Effekt lag hierbei auf
der Bewertungsmenge, ein Prozent mehr Bewertungen führt zu 4
Prozentpunkten Steigerung in der online geäußerten
Patientenzufriedenheit.
Schlussfolgerung In dieser Studie konnte nachgewiesen werden, dass sich
über 30% der Varianz bei den online Bewertungen durch Faktoren
erklären lässt, die nicht direkt kausal mit der Qualität
der Versorgung verbunden sind. Eine Annährung an interne
Bewertungsergebnisse wäre damit durch eine reine Erhöhung der
Portalnutzung möglich.
Thermally Activated Aryl Thioureas as Brønsted Acid Catalysts for C–C Bond Forming Reactions: Synthesis of Symmetrical Trisubstituted Methanes
Authors: Bez Ghanashyam , Gogoi Achinta , Basumatary Grace 
Published: September 2022

AbstractA study on relative catalytic efficacy of 1,3-diaryl thioureas has revealed that 1-[3,5-bis(trifluoromethyl)phenyl]-3-phenylthiourea is an efficient alternative to the Schreiner’s thiourea catalyst (STC) for acid-catalyzed activation of carbonyl compounds in the synthesis of symmetrical trisubstituted methanes (TRSMs) at an elevated temperature. Since the preparation of STC involves the use of toxic thiophosgene, the 1-[3,5-bis(trifluoromethyl)phenyl]-3-phenylthiourea represents an easily accessible and simpler alternative. Strikingly, the temperature-assisted reaction showed significantly shorter reaction time in comparison to photoirradiation in the thiourea-catalyzed Friedel–Crafts type reaction of indole with aldehydes. Simple reaction set-up and excellent yields are some of the highlights of the reported method.
Paradoxical Continuous Left-to-Right Ductal Shunt during Circulatory Collapse due to Ductal Closure in an Infant with Duct-Dependent Systemic Circulation
Authors: Miyahara Naoyuki , Hussein Mohamed Hamed , Nishiguchi Ryou , Kanai Masayo , Ishiguro Akio , Toda Koichi , Kojima Takuro , Yoshiba Shigeki , Sumitomo Naokata , Masutani Satoshi 
Published: September 2022

AbstractDuct-dependent systemic circulation is accompanied by a right-to-left ductal shunt, at least during systole. Although observations of paradoxical continuous left-to-right shunts in duct-dependent systemic circulation have been reported, the mechanism remains unclear. We report a continuous left-to-right ductal shunt throughout the cardiac cycle during the initial recovery phase from circulatory collapse and right ventricular (RV) dysfunction due to ductal closure in an infant with hypoplastic left heart and severe aortic coarctation. Further recovery improved his RV function and changed the ductal flow from continuous left-to-right to bidirectional, which is usually seen in duct-dependent systemic circulation. Marked RV dysfunction may contribute to the continuous left-to-right ductal shunt. A continuous left-to-right ductal shunt should not be used to rule out duct-dependent systemic circulation.
Neuropsychological Profile of Traumatic Brain Injury Patients with Medicolegal Cases: A Pilot Study
Authors: Prakash Simi K. , Reddy Rajakumari P. , Mathulla Anna R. , Rajeswaran Jamuna , Shukla Dhaval P. 
Published: September 2022

Abstract
Introduction Traumatic brain injury (TBI) is a global health problem and is a silent epidemic of the modern times. Studies indicate litigation is a prominent factor that accounts for poor outcome and prolonged recovery from mild TBI. Depression is the most frequently diagnosed psychiatric disorder after TBI. Postconcussion symptoms, litigation, and suboptimal effort could contribute to the neuropsychological functioning of TBI patients medicolegal cases (MLCs). With increase in TBI and medicolegal cases, there is a requirement for comprehensive neuropsychological assessment.
Method The aim of the study was to evaluate the cognitive functions, postconcussion, and depressive symptoms in TBI patients with MLC and without MLCs (non-MLC). Patients were also assessed on electrophysiological parameters. An observational cross-sectional design was adopted, the sample size was 30 TBI patients in total, 15 (MLC) and 15 (non-MLC), and 11 patients from each group for electrophysiological assessment. The patients were in the age range of 18 to 50 years.
Results The MLC group had poor performance compared with the non-MLC group on both neuropsychological and electrophysiological measures. There was evidence of significant difference in verbal working memory, verbal learning, and memory and visuoconstructive ability. In the MLC group, postconcussion and depressive scores were negatively correlated with visuospatial span.
Conclusion Findings from this study indicate differences in the neuropsychological performance and electroencephalographic measures in between MLC and non-MLC groups. The results could be indicative of persistent cognitive problems associated with TBI for patients pursuing litigation. Poor performance could also be attributed to suboptimal level of effort. However, being a preliminary study with a small sample size, the findings need to be treated with caution.
Challenges in the Diagnosis and Treatment of Patients with Rare and Orphan Diseases
Authors: Nagi Ravleen , Rakesh N. , Reddy Sujatha S. , Bhatnagar Dipti , Reddy Prashanthi , Vyas Tarun , Choudhary Ruchika 
Published: September 2022

AbstractOrphan diseases are diverse group of disorders that have not gained much of public attention as they are rarely reported worldwide. The term orphan and rare diseases are often used interchangeably when describing diseases that fall into an orphan or rare category. Around 80% of orphan diseases are chronic, serious, or life threatening, are of genetic origin, and are more prevalent in children and in adults above 40 years of age. Due to rarity, lack of financial support and specific drug to treat these diseases, diagnosis, and treatment becomes challenging. Diagnosis is usually delayed, and patient continues to suffer by seeking multiple specialist opinion. Nonavailability of specific drug and lack of financial funding or waivers to conduct to conduct clinical trial for invention of new orphan drug are the obstacles for targeted treatment. Hence, there is need for comprehensive integrative approach to manage orphan disease patients and pharmaceutical companies should be encouraged for invention of drugs at a reasonable cost for orphan diseases. In addition, community education through genetic-based learning modules is essential to increase awareness of population about risk factors and early diagnosis of orphan diseases, and to take opinion of specific specialist for thorough clinical evaluation. This review discusses challenges faced by the specialists toward diagnosis and treatment of orphan disease for well-being of an individual living with the disorder.
Changes in COVID-19 Perception and in TMD Prevalence after 1 Year of Pandemic in Italy
Authors: Scelza Giuseppe , Amato Alessandra , Rongo Roberto , Nucci Ludovica , D'Ambrosio Francesco , Martina Stefano 
Published: September 2022

Abstract
Objectives The study aims to report the perception of dental practices and assess the individual's psychological stress level and related temporomandibular disorders (TMD) symptoms by evaluating the changes that occurred during the year following the first lockdown (May 2020).
Materials and Methods An online questionnaire was submitted to the Italian population between 20 March and 20 April 2021. It was sent via online platforms and included 14 questions.
Statistical analysis The data were analyzed using a chi-squared test and a comparison of the current data with the May 2020 survey data was performed using independent samples t-tests. The level of significance was set at p < 0.05.
Results Forty-three percent of subjects (872) considered the dental practice to be a place with a high risk of infection. Temporomandibular pain and joint sounds were reported by 35.7% (724) of the population; of these more frequently were women (71.8%, 520/724, p < 0.001). About 31% of the participants had moderate/severe psychological distress and, among them, it was found that 46.4% (294/634) reported TMD pain (p < 0.001) and 34.9% (221/634) complained of temporomandibular joint sounds (p < 0.001).
Conclusions Most participants did not consider dental practices as a place with a higher risk of coronavirus disease 2019 transmission and, in contrast to the data from a previous study, people were less afraid to go to dental practices. After the first year of the pandemic, the level of stress and depression increased and the prevalence of TMD pain and joint sounds increased, in association with gender, age, and level of distress.
The amplification effect of unreasonable human behaviours on natural disasters
Authors: Fan Jie , Liu Baoyin , Ming Xiaodong , Sun Yong , Qin Lianjie 
Published: September 2022

AbstractNatural disasters occur when environmental systems have a disruptive effect on the socio-economic system. In recent years, particular unreasonable human behaviours have amplified losses from natural disasters as result of the increasing complexity of human systems. Because of the lack of both quantitative calculation of this amplification, and analysis of the root cause of these behaviours, existing risk assessment and management research rarely includes unreasonable human behaviour as a critical factor. This study therefore creates three simulation scenarios, each based on a twenty-first-century catastrophe in China, and calculates the disaster losses that are amplified when such behaviour increases exposure (the 2008 Wenchuan earthquake), vulnerability (the 2014 Ludian earthquake) and hazard (the 2021 Zhengzhou rainstorm) levels. In doing so, it intuitively demonstrates the amplification effect caused by unreasonable human behaviour. The results show that these behaviours amplified disaster losses significantly: increased exposure due to unscientific planning nearly doubled the death toll in the Wenchuan earthquake; high vulnerability caused by the low economic level of residents increased the disaster losses of the Ludian earthquake more than tenfold; and the elevated hazard intensity caused by anthropogenic climate change resulted in a 1.44-times expansion of the area severely affected by the Zhengzhou rainstorm. These behaviours have become an important cause of disasters, and the main driving factors behind them—such as neglecting disaster risk; the inability to cope with disasters; and a lack of certainty about how to deal with extreme events—are the inevitable outcomes of societal development. On this basis, we constructed an extended risk framework that included unreasonable behavioural factors and a disaster mechanism, to analyse in depth the relationship between human behaviours and disaster risk prevention in different developmental stages. The results provide an important reference for the development of risk management policies to control these unreasonable behaviours.
All-solid-state AlGaN/GaN-based ion-sensitive heterostructure field effect transistor pH sensor microprobe encapsulated in medical needle
Authors: Wang Fengge , Zhang Minjie , Liu Honghui , Xu Yanyan , Liang Zhiwen , Shen Junyu , Xiao Zhengwen , Yan Chaokun , Wu Zhisheng , Liu Yang , Zhang Baijun 
Published: September 2022

It is very important to monitor pH values. In this paper, we fabricated an all-solid-state AlGaN/GaN-based ion-sensitive heterostructure field effect transistor (ISHFET) pH sensor microprobe. The microprobe could facilitate measurement of pH values. The microprobe was fabricated by packaging the pH sensor microprobe chip into a 21 G medical needle. The performance of the integrated pH sensor microprobe was evaluated in pH range of 4–9.18. A sensitivity of 143.57 µA/pH can be achieved using the pH sensor microprobe with a width to length ratio of 4.2 at a drain–source voltage of 0.5 V. The pH sensor microprobe keeps a similar current when the pH values of solutions are the same. A response time of 1 s can be achieved when no neutralization reaction occurs. The pH sensor microprobe can accurately measure pH of solutions under 0.1M interfering ions. This probe-type AlGaN/GaN-based ISHFET pH sensor may be used in medicine or biology, especially in the detection of pH of biological fluid, blood, and some precious biological samples.
What is in the learner’s mind when trying to verbalize grammatical rules?
Authors: Son Vi Thanh , Håkansson Gisela 
Published: September 2022

Abstract
The present study examines the outcome of teaching second language English (L2 English) third-person singular present tense -s for declarative knowledge in two different settings, namely Sweden and Vietnam. Third person -s is one of the most studied grammatical structures in second language acquisition research. Data are collected in two classroom contexts with different teaching traditions. Participants are 76 young learners, 11–12 years old, 32 with Swedish as L1 and 44 with L1 Vietnamese. The results demonstrate differences in learner outcomes in these two groups. The Vietnamese learners outperformed the Swedish learners on the tests of declarative knowledge. The analyses of learner explanations of third-person singular present tense -s reveal that learners tend to decompose this complex rule into several features, which sometimes lead them into misconceptions. This has pedagogical implications about EFL teaching and learning for young learners.
An open-source bioink database for microextrusion 3D printing
Authors: Mahadik Bhushan , Margolis Ryan , McLoughlin Shannon , Melchiorri Anthony , Lee Sang Jin , Yoo James , Atala Anthony , Mikos Antonios G , Fisher John P 
Published: September 2022

Abstract
3D printing has rapidly become a critical enabling technology in tissue engineering and regenerative medicine for the fabrication of complex engineered tissues. 3D bioprinting, in particular, has advanced greatly to facilitate the incorporation of a broad spectrum of biomaterials along with cells and biomolecules of interest for in vitro tissue generation. The increasing complexity of novel bioink formulations and application-dependent printing conditions poses a significant challenge for replicating or innovating new bioprinting strategies. As the field continues to grow, it is imperative to establish a cohesive, open-source database that enables users to search through existing 3D printing formulations rapidly and efficiently. Through the efforts of the NIH/NIBIB Center for Engineering Complex Tissues, we have developed, to our knowledge, the first bioink database for extrusion-based 3D printing. The database is publicly available and allows users to search through and easily access information on biomaterials and cells specifically used in 3D printing. In order to enable a community-driven database growth, we have established an open-source portal for researchers to enter their publication information for addition into the database. Although the database has a broad range of capabilities, we demonstrate its utility by performing a comprehensive analysis of the printability domains of two well-established biomaterials in the printing world, namely poly(ϵ-caprolactone) and gelatin methacrylate. The database allowed us to rapidly identify combinations of extrusion pressure, temperature, and speed that have been used to print these biomaterials and more importantly, identify domains within which printing was not possible. The data also enabled correlation analysis between all the printing parameters, including needle size and type, that exhibited compatibility for cell-based 3D printing. Overall, this database is an extremely useful tool for the 3D printing and bioprinting community to advance their research and is an important step towards standardization in the field.
Implementation of a pharmacist skill development “work-with” program
Authors: Rourke Wallace , Pagel Kaitlyn , Dumont Zack , Len Suzanne , Roy Caitlin 
Published: September 2022

Abstract

Purpose
Pharmacists’ clinical competency is necessary to ensure patient safety and medication optimization. There are many barriers to the implementation of competency assessments and scant literature on their implementation. We aimed to determine if a competency assessment program for hospital pharmacists is feasible, acceptable, and effective.

Methods
Clinical competency assessments of hospital pharmacists were conducted. During the assessments, pharmacists presented a patient case or completed patient care activities while a leadership team member evaluated them using a competency rubric and provided feedback. A postevaluation electronic survey adapted from validated tools regarding perceptions of program feasibility and acceptability was emailed to the pharmacists following each competency assessment and to evaluators at study conclusion. Feasibility was also measured through reviewing rubrics for completion within the 1.5- to 2-hour assessment timeframe. Effectiveness was captured by comparing results to expected competency levels based on experience.

Results
In total, 20 assessments were completed. Fifty percent of assessments required longer than the allotted timeframe. Most participants surveyed found the competency assessments implementable, possible, doable, and easy to use. The majority also approved of the implemented assessments and found them appealing, likable, and welcomed and commented that they aided in professional development. For 50% of the competencies assessed, most participants aligned with competency expectations based on years of experience.

Conclusion
The implementation of these competency assessments was found to be feasible and acceptable to hospital pharmacists. The rubric used was found to be moderately effective. Major implementation barriers were related to time constraints and criteria for success. Future work will be done to enhance the program’s effectiveness.
Comparison of scRNA-seq data analysis method combinations
Authors: Xu Li , Xue Tong , Ding Weiyue , Shen Linshan 
Published: September 2022

AbstractSingle-cell ribonucleic acid (RNA)-sequencing (scRNA-seq) data analysis refers to the use of appropriate methods to analyze the dataset generated by RNA-sequencing performed on the single-cell transcriptome. It usually contains three steps: normalization to eliminate the technical noise, dimensionality reduction to facilitate visual understanding and data compression and clustering to divide the data into several similarity-based clusters. In addition, the gene expression data contain a large number of zero counts. These zero counts are considered relevant to random dropout events induced by multiple factors in the sequencing experiments, such as low RNA input, and the stochastic nature of the gene expression pattern at the single-cell level. The zero counts can be eliminated only through the analysis of the scRNA-seq data, and although many methods have been proposed to this end, there is still a lack of research on the combined effect of existing methods. In this paper, we summarize the two kinds of normalization, two kinds of dimension reduction and three kinds of clustering methods widely used in the current mainstream scRNA-seq data analysis. Furthermore, we propose to combine these methods into 12 technology combinations, each with a whole set of scRNA-seq data analysis processes. We evaluated the proposed combinations using Goolam, a publicly available scRNA-seq, by comparing the final clustering results and found the most suitable collection scheme of these classic methods. Our results showed that using appropriate technology combinations can improve the efficiency and accuracy of the scRNA-seq data analysis. The combinations not only satisfy the basic requirements of noise reduction, dimension reduction and cell clustering but also ensure preserving the heterogeneity of cells in downstream analysis. The dataset, Goolam, used in the study can be obtained from the ArrayExpress database under the accession number E-MTAB-3321.
APPRIS principal isoforms and MANE Select transcripts define reference splice variants
Authors: Pozo Fernando , Rodriguez José Manuel , Martínez Gómez Laura , Vázquez Jesús , Tress Michael L 
Published: September 2022

AbstractMotivationSelecting the splice variant that best represents a coding gene is a crucial first step in many experimental analyses, and vital for mapping clinically relevant variants. This study compares the longest isoforms, MANE Select transcripts, APPRIS principal isoforms, and expression data, and aims to determine which method is best for selecting biological important reference splice variants for large-scale analyses.ResultsProteomics analyses and human genetic variation data suggest that most coding genes have a single main protein isoform. We show that APPRIS principal isoforms and MANE Select transcripts best describe these main cellular isoforms, and find that using the longest splice variant as the representative is a poor strategy. Exons unique to the longest splice isoforms are not under selective pressure, and so are unlikely to be functionally relevant. Expression data are also a poor means of selecting the main splice variant. APPRIS principal and MANE Select exons are under purifying selection, while exons specific to alternative transcripts are not. There are MANE and APPRIS representatives for almost 95% of genes, and where they agree they are particularly effective, coinciding with the main proteomics isoform for over 98.2% of genes.Availability and implementationAPPRIS principal isoforms for human, mouse and other model species can be downloaded from the APPRIS database (https://appris.bioinfo.cnio.es), GENCODE genes (https://www.gencodegenes.org/) and the Ensembl website (https://www.ensembl.org). MANE Select transcripts for the human reference set are available from the Ensembl, GENCODE and RefSeq databases (https://www.ncbi.nlm.nih.gov/refseq/). Lists of splice variants where MANE and APPRIS coincide are available from the APPRIS database.Supplementary informationSupplementary data are available at Bioinformatics online.