bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of dual-trigger regimen in improving outcomes for pregnancy in different ovarian respond patients: a retrospective study
Authors: Wang Jinrong , Xu Ke , Yang Shuangshuang , Hou Ning , Sun Mei 
Published: November 2022

Abstract
Objective
Observing pregnancy outcomes of patients who used dual-trigger and single-trigger regimens in different ovarian responders who received ART, and assessing the effectiveness and safety of the regimens to provide insights into the optimization of clinical strategy.
Methods
The clinical profile of 2778 infertile patients who received ART (IVF/ICSI) were reviewed and collected retrospectively. Patients enrolled with different ovarian responses were divided into single-trigger and dual-trigger groups based on different real-world trigger protocols. The baseline characteristics, ovulation induction and pregnancy outcomes of the patients were statistically analyzed.
Results
There were no significant differences in characteristics of the baseline and cycle parameters on the two trigger regimen groups for high responders, normal responders and low responders. The number of oocytes and the oocytes retrieval rate by the dual trigger of normal responders and high responders have increased, but there were no significant differences in pregnancy outcomes (embryo transfer rate, pregnancy rate, live birth rate) between trigger groups. The dual trigger had a lower transplant cancellation rate due to prevention of OHSS: high responders (P = 0.927), normal responders (P = 0.251). In poor responders, there were no cases of transplantation cancellation for OHSS prevention in both groups.
Conclusion
The dual trigger is a relatively effective and safe regimen for patients with high response and normal ovarian response. In patients with poor ovarian response, the evidence for reducing the risk of OHSS is not sufficient. Further validation in larger, well-designed randomized controlled trials on whether dual triggering improves pregnancy outcomes in poor responders is needed.
Explicit Finite Difference Analysis of Pseudo-Hyperbolic Partial Differential Equations
Authors: Modanli Mahmut , Abdulazeez Sadeq Taha , Akgül Ali 
Published: November 2022

Abstract
The explicit finite difference method is suggested in this publication to resolve pseudo-hyperbolic partial differential equations. An explicit finite difference scheme is developed for the suggested problem. The estimated and exact solutions are compared to create the error analysis table. The stability inequalities for this difference scheme are demonstrated using matrix analysis. An example is illustrated as an implementation of the finite difference scheme method. The results show that the proposed method is very accurate and convenient. The solutions are represented graphically. Other numerical methods can be applied to investigate pseudo-hyperbolic partial differential equations.
In situ diagnostics of the Si etching structures profile in ICP SF6/C4F8 plasma: Macrostructures
Authors: Osipov Artem , Gagaeva Alina , Speshilova Anastasiya , Osipov Armenak , Enns Yakov , Kazakin Alexey , Endiiarova Ekaterina , Kornilov Roman , Alexandrov Sergey 
Published: November 2022

Abstract
In this work we studied the influence of technological parameters of plasma chemical etching of silicon on photoresist etching rate, silicon etching rate, etching selectivity of silicon in relation to photoresist, and inclination angle of the profile wall of the etched windows. Based on the obtained results, a common regularity between the inclination angle of the profile wall of the etched windows and the optical emission spectra was revealed. The method of in situ diagnostics was proposed, namely, controlling the inclination angle of the profile wall of the etched windows by the ratio of the emission intensities of the carbon line (517.1 nm) to the fluorine line (685.8 nm and 703.9 nm) designated as parameter X. It was found that the inclination angle of the profile wall of the etched windows takes certain values depending on the value of the X parameter. The ranges of X values, at which the inclination angle of the profile wall of the etched windows is acute, right, and obtuse are estimated. So, at values of X from ≈0.15 to ≈0.35 the acute angle (from 81±0.5° to 89±0.5°) is obtained, at X from ≈0.35 to ≈0.42 the right angle is obtained (90±0.5°), and at X from ≈0.42 to ≈0.75 the values of the inclination angle of the profile wall of the etched windows are in the range from 91±0.5° to 94±0.5°, no matter which technological parameters were set. Experiments were conducted for etching windows with linear dimensions from 0.5x20 mm to 2x20 mm.
Prophylactic muscle injection treatment for fatty degeneration in rotator cuff injury: A systematic review of animal studies
Authors: Nihei Kota , Murata Kenji , Sone Kenta , Nagata Shiori , Kawabata Sora , Kojima Takuma , Takasu Chiharu , Terada Hidenobu 
Published: November 2022

Abstract
Introduction: Fatty degeneration is the most important factor affecting massive rotator cuff tear (RCT) function. However, the mechanism underlying fatty degeneration and treatment after massive rotator cuff injury remains to be elucidated. This study sought to systematically scoping review published animal studies to explore effective treatment options for fatty degeneration following human rotator cuff injury, focusing on fibro-adipogenic progenitor (FAP).
Materials and methods: MEDLINE, PubMed, and Embase were systematically searched for articles published in June 2022, using relevant keywords. Animal species, injury and repair types, study duration, and fatty degeneration parameters were summarized.
Results: Of the 120 studies, 51 were secondarily evaluated for cell treatment of fatty degeneration in rotator cuff injury. Finally, 6 studies examining the effects of FAP on fatty degeneration were selected for analysis. Six studies showed positive effects on the SS muscle following fibro/adipogenic progenitor (FAP) (n = 3) or pluripotent stem cell (n = 3) injections.
Conclusion: Following the review, we concluded the following: 1) FAP cell injections effectively inhibit fatty degeneration after rotator cuff injury.
Level of evidence: Level IV, review article.
Repercussion of Conflicts caused through Chemical Defilement and Eradication in Contemporary Existence
Authors: Katke Sai 
Published: November 2022

Abstract
Conflicts can occur as a result of any natural phenomena or any man-made activity that causes anguish in human brains; comprehending chemical contamination and elimination is the goal for global security. Many worldwide conferences attempt to balance and regulate such incidents; yet, prolonging any such event is a monumental task; however, and therefore learning and preventing for knowledge of any repercussions is a debate. It is difficult to summarize chemical conflicts, hazards, toxic gases, weapons, warfare, chemical mixtures/compositions contamination, conversions, and so on. We have covered briefly their literature, repercussions, risks, and preventions for any confrontations resulting in chemical outbursts below.
How Do Logistics Disruptions Affect Rural Households? Evidence from COVID-19 in China
Authors: Huang Difang , Chen Muzi , Nan Li 
Published: November 2022

Abstract
Using a comprehensive survey of households during the early stage of the COVID-19 pandemic in China, we find that logistics disruptions due to the lockdown have resulted in severe economic losses for rural households. Further analysis shows that storage of agricultural inputs and outputs, insurance, and macroeconomic factors are associated with such losses during this period. We further examine the mechanisms by which logistics disruptions affect rural households, including both sales and production channels in agricultural supply chains. The former includes changes in product prices and reduced sales, while the latter includes changes in input prices and shortages of raw materials, capital, and labor. Of these channels, logistics has the most severe impact on sales. Opening up the logistics of sales channels is the primary policy choice. More storage warehouses and insurance are also important preemptive measures. Building stable and sustainable agricultural supply chains ensure rural households' production during the pandemic.
Convolutional Neural Networks Trained to Identify Words Provide a Good Account of Visual Form Priming Effects
Authors: Yin Dong , Bowers Jeffrey , Biscione Valerio 
Published: November 2022

Abstract
A wide variety of orthographic coding schemes and models of visual word identification have been developed to account for masked priming data that provide a measure of orthographic similarity between letter strings. These models tend to include hand-coded orthographic representations with single unit coding for specific forms of knowledge (e.g., units coding for a letter in a given position or a letter sequence). Here we assess how well a range of these coding schemes and models account for the pattern of form priming effects taken from the Form Priming Project and compare these findings to results observed in with 11 standard deep neural network models (DNNs) developed in computer science. We find that deep convolutional networks perform as well or better than the coding schemes and word recognition models, whereas transformer networks did less well. The success of convolutional networks is remarkable as their architectures were not developed to support word recognition (they were designed to perform well on object recognition) and they classify pixel images of words (rather artificial encodings of letter strings). The findings add to the recent work of (Hannagan et al., 2021) suggesting that convolutional networks may capture key aspects of visual word identification.
The estimation of coronary artery calcium thickness by computed tomography angiography based on optical coherence tomography measurements
Authors: Okutsu Masaaki , Mitomo Satoru , Onishi Hirokazu , Nakajima Akihiro , Yabushita Hiroto , Matsuoka Satoshi , Kawamoto Hiroyoshi , Watanabe Yusuke , Tanaka Kentaro , Naganuma Toru , Tahara Satoko , Nakamura Shotaro , Basavarajaiah Sandeep , Nakamura Sunao 
Published: November 2022

Abstract
Purpose
Optical coherence tomography (OCT) is recommended to be the most appropriate modality in assessing calcium thickness, however, it has limitations associated with infrared attenuation. Although coronary computed tomography angiography (CCTA) detects calcification, it has low resolution and hence not recommended to measure the calcium size. The aim of this study was to devise a simple algorithm to estimate calcium thickness based on the CCTA image.
Methods
Consecutive patient who had CCTA for suspected coronary artery disease and subsequently went on to have OCT were included in the study. Calcium CT density was collected from CT profile curve. The method to estimate calcium thickness was devised from maximum CT density within the calcification and compared to the measured calcium thickness by OCT. The accuracy of this method was compared to full width at half maximum (FWHM) or inflection point (IP) method.
Results
A total of 68-patients (238-lesions) divided into derivation and validation dataset at 2:1 ratio (47 patients with 159 lesions and 21 with 79, respectively) were analyzed. Maximum Calcium density and measured calcium-border CT density had a good correlation with a linear equation of y = 0.58x + 201 (r = 0.892, 95% CI: 0.855–0.919, p < 0.001). The estimated calcium thickness derived from this equation showed strong agreement with measured calcium thickness in validation and derivation dataset (r2 = 0.481 and 0.527, 95% CI: 0.609–0.842 and 0.497–0.782, p < 0.001 in both, respectively), more accurate than the estimation by FWHM and IP method.
Conclusion
This novel method provided the estimation of calcium thickness more accurately than conventional methods.
Activated volcanism of Mount Fuji by the 2011 Japanese large earthquakes
Authors: Nanjo Kazuyoshi , Yukutake Yohei , Kumazawa Takao 
Published: November 2022

Abstract
The relation between earthquakes and volcanic eruptions, each of which is manifested by large-scale tectonic plate and mantle motions1, has been widely discussed2-7. Mount Fuji in Japan last erupted in 1707, paired with a magnitude (M)-9-class earthquake that took place 49 days prior8-10. Motivated by this pairing, previous studies examined the effect of both the 2011 M9 Tohoku megaquake and a triggered M6-class earthquake 4 days later at the foot of the volcano on Mount Fuji, although no volcanic eruption was reported11,12. More than 300 years already have passed since the last 1707 eruption, and although consequences to humans and society caused by the next eruption are already being considered, the implication for future volcanism remains uncertain. Here we show how volcanic low-frequency earthquakes (LFEs)14-18 in the deep part of the volcano revealed hitherto-unrecognized activation immediately after the foot earthquake. Our analyses19-27 showed that despite an increase in the rate of occurrence of LFEs, these did not return to pre-earthquake levels, indicating a change in the magma system. Our results demonstrate that the volcanism of Mount Fuji was reactivated by the foot earthquake, implying that this volcano is sufficiently sensitive to external events that are enough to trigger eruptions.
The causal involvement of the BDNF-TrkB pathway in dentate gyrus in early-life stress-induced cognitive deficits
Authors: Li Ji-Tao , Sun Yaxin , Su Yun-Ai , Wang Qi , Wang Ting , Zheng Jia-Ya , Zhang Chen-Chen , Liu Xiao , Ma Yu-Nu , Li Xue-Xin , Zhang Xianqiang , Xie Xiaomeng , Si Tian-Mei 
Published: November 2022

Abstract
Cognitive dysfunction is a signiﬁcant, untreated clinical need in patients with psychiatric disorders, for which preclinical studies are needed to understand the underlying mechanisms and to identify potential therapeutic targets. Early-life stress (ELS) leads to long-lasting deficits of hippocampus-dependent learning and memory in adult mice, which may be associated with the hypofunction of the brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, tropomyosin receptor kinase B (TrkB). In this study, we carried out eight experiments to examine the causal involvement of the BDNF-TrkB pathway in dentate gyrus (DG) and the therapeutic effects of the TrkB agonist (7,8-DHF) in ELS-induced cognitive deficits. Adopting the limited nesting and beding material paradigm, we first demonstrated that ELS impaired spatial memory, suppressed BDNF expression and neurogenesis in DG in adult mice. Down-regulating BDNF expression (conditional BDNF knockdown) or inhibition of the TrkB receptor (using its anatognist ANA-12) in the DG mimicked the cognitive deficits of ELS. Acute up-regulation of BDNF (exogenous human recombinant BDNF microinjection) levels or activation of TrkB receptor (using its agonist, 7,8-DHF) in the DG restored ELS-induced spatial memory loss. Finally, acute and subchronic systemic administration of 7,8-DHF successfully restored spatial memory loss in stressed mice. Subchronic 7,8-DHF treatment also reversed ELS-induced neurogenesis reduction. Our findings highlight BDNF-TrkB system as the molecular target of ELS-induced spatial memory deficits and provide translational evidence for the intervention at this system in the treatment of cognitive deficits in stress-related psychiatric disorders, such as major depressive disorder.
The effect of caspase-8 as an apoptotic marker in relation to COVID-19 patients severity
Authors: Eyada Zainab Noaman , Al-Timimi Raid J. M. , alkubaisi haitham , Abdulateef Yasir .M 
Published: November 2022

Abstract
Objective: In Iraq, the COVID-19 pandemic was catastrophic, leading to mortality and morbidity. One of the leading causes of mortality was cell apoptosis that leads to organ failure.
Aim: To diagnose the cell apoptosis of COVID-19 patients at an early stage so we can predict earlier organ failure.
Methods: The research was conducted in the medicinal chemistry department of Al-Nahrain University/College of Medicine in Baghdad, Iraq. One hundred patients of different stages proved COVID-19 and compared with 100 persons in the control group, measure caspase-8 enzyme and acute inflammatory markers, procalcitonin (PCT), and IL-6 with COVID-19 immunoglobulins IgG, IgM in the blood of two groups. We're done—statical studies with clinical analysis results.
Results: The marker of cell apoptosis was caspase-8 enzymes, which showed vertical elevation with the increase in severity of COVID-19 patients. There was a strong relationship between the caspase-8 enzyme and acute inflammatory markers. Moreover, there is a relationship between the caspase-8 enzyme and COVID-19 immunoglobulins.
Conclusion: The caspase-8 enzyme is a strong marker of severity in COVID-19 patients and indicates a life-threatening condition.
An assessment of volatility and leverage effect before and during the period of Covid-19: a study of selected international stock markets
Authors: Bhunia Amalendu , Ganguly Soumya 
Published: November 2022

Abstract
This research work assesses the volatility and leverage effect of the selected stock markets before and during the outburst of the Covid-19 of the selected international stock markets. This study is based on daily time-series data obtained from yahoo.finance database. The period of the study has been considered from 1 September 2019 to 31 December 2019, before the period of Covid-19, and from 1 January 2020 to 30 April 2020, during the period of Covid-19. In the course of analysis, descriptive statistics, the GARCH model, the EGARCH model, and the TGARCH model have been used. The GARCH test results show that volatility existed before and during the period of Covid-19. Both E-GARCH and T-GARCH test results show that the leverage effect existed before and during the period of Covid-19. So, the impact of the Covid-19 pandemic in terms of bad news has a bigger influence on international stock markets.
The emergent pattern of infant stage ocean warming in satellite measurements
Authors: Yang Hu , Lohmann Gerrit , Stepanek Christian , Wang Qiang , Huang Rui Xin , Shi Xiaoxu , Liu Jiping , Chen Dake , Wang Xulong , Zhong Yi , Yang Qinghua , Bao Ying , Müller Juliane 
Published: November 2022

Abstract
Satellite-observed sea surface temperature (SST) provides an unprecedented opportunity to evaluate the ongoing global warming and has recently reached a milestone of 40 years temporal coverage. One of the major warming patterns captured by satellites is relatively strong subtropical ocean warming across all ocean basins. This pattern was widely interpreted as a manifestation of the Pacific Decadal Oscillation, a natural climate variability. However, we find that the observed warming pattern, characterized by strong warming over the subtropical oceans and mild warming or even cooling over the subpolar oceans, is dynamically consistent with where the surface water converges and diverges. By comparing observations with paleo-reconstructions and simulated short-term and long-term SST response to CO2 forcing, we propose that the observed warming pattern is likely in a transient early warming stage constrained by background ocean circulation. In the long term, ocean warming at high latitudes is expected to exceed the temporally dominating subtropical ocean warming. The committed, but lagged, high-latitude ocean warming has potential to reshape the ocean-atmosphere circulation and threaten the stability of marine-terminating ice sheets.
Fusion, Micronization and Bio-activated (FMB) extract of Gymnema sylvestre for higher antidiabetic and antioxidant effects compared to its conventional standardized extract
Authors: Ibrahim Mohammad , Gokarn Vijay , Tamoli Sanjay 
Published: November 2022

Abstract
Despite considerable studies, diabetes continues to remain a challenge for its prevention and management with an increasing rate of morbidity and mortality. One of the popular herbal extracts - Gymnema sylvestre has been extensively studied for its anti-diabetic potential. The present study aimed to explore the in vitro antidiabetic and antioxidant effects of Gymnema sylvetsre (Gudmar; GD) and also reveal its drug-likeness, toxicity and action mechanism by utilizing in silico molecular docking and network pharmacology, respectively. The elemental analysis confirmed that FMB technology successfully replenishes iron, zinc and calcium in the conventional extract which is devoid of these essential trace elements. GD extract-FMB (IC50 = 131.90 ± 0.44) are more effective as compared to conventional GD extract in the case of α-amylase (IC50 = 118.23 ± 0.42; IC50 = 109.52 ± 0.34) and α-glucosidase (IC50 = 109.52 ± 0.34), respectively while a similar effect was observed in DPPH-free radical scavenging (IC50 = 129.2 ± 0.98) of GD extract-FMB as compared to GD extract (IC50 = 176.6 ± 0.51). Network pharmacology revealed that key target proteins that are strongly linked to iron, zinc and calcium were strongly involved in glucose metabolism, oxo-inflammatory responses and insulin-related pathways. In addition, in silico molecular docking results of gymnemic acid against α-amylase and α-glucosidase revealed strong biological bindings. Conclusively, based on the finding we can conclude that FMB technique replenish the ETEs in the conventional extract. Also FMB processing is beneficial and provides a innovative solution for the herbal pharmaceutical industry to develop better efficacious extracts or herbal formulations.
Les faits établis par des accords étrangers et des rapports internes - une base valide pour une décision pénale suisse ?
Authors: Capus Nadja , Nunnari Basilio 
Published: November 2022

Les jugements des grandes affaires de corruption transnationale et de blanchiment d'argent font apparaître une nouvelle pratique qui consiste à établir les faits sur la base du contenu des transactions pénales judiciaires. À partir d'un cas actuel concernant Gulnara Karimova, nous identifions concrètement deux méthodes: d'une part, la communication et la transplantation transnationale des faits qui ont été établis dans des procédures de négociation (des accords) conclues à l'étranger et, d'autre part, le recours à des rapports internes. Cette contribution décrit ce phénomène, la problématique juridique et les préoccupations pratiques y relatives, en particulier quant à l'admissibilité et la valeur probante du contenu des accords et des rapports internes.
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Die Urteile in umfangreichen Fällen grenzüberschreitender Korruption und Geldwäsche lassen eine neue Praxis erkennen, die darin besteht, Sachverhalte auf der Grundlage des Inhalts von Absprachen zu ermitteln. Anhand eines aktuellen Falles betreffend Gulnara Karimova werden zwei konkrete Methoden dieser Vorgehensweise identifiziert: zum einen die transnationale Kommunikation und schlichte Übernahme von Fakten, die in ausländischen Absprachen ausgehandelt wurden, und zum anderen der Rückgriff auf interne Berichte. Dieser Beitrag beschreibt das Phänomen, erläutert die rechtliche Problematik und die praktischen Bedenken, insbesondere in Bezug auf die Zulässigkeit und den Beweiswert des Inhalts der Absprachen und internen Berichten.