bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modified Minerva Orthosis for Postoperative Management of Cricotracheal Resection in Children
Authors: Christ Megan Z. , Ha Jennifer F. , Baerg Timothy , Green Glenn E. 
Published: March 2022

ABSTRACT

Introduction
Cricotracheal resection (CTR) and tracheal resection (TR) are open surgical options to treat airway stenoses. One of the most devastating complications is anastomosal dehiscence, owing to excessive tension on the anastomosis from cervical extension. To prevent excessive tension on the anastomosis during the postoperative period, the neck is kept in a neutral or slightly flexed position. We describe a novel design and fitting of a modified pediatric Lerman Minerva cervical-thoracic orthosis (CTO) in our pediatric patient population after CTR or TR to protect the anastomosis.

Method
A Minerva CTO is customized to reduce anastomotic tension. The mandibular extension is removed, occipital extension is recontoured, plastic is trimmed, and a perineal strap is added. The orthosis allows avoidance/removal of the manubrial-mandibular suture, reducing skin complications and increasing mobilization.

Discussion
This modified Minerva CTO provided three key benefits: it can be sized down to fit small children, provides the desired immobilization, and is adjustable during fitting to ensure that the angle of cervical flexion is appropriate to protect the anastomosis.

Conclusion
After CTR and TR, proper cervical positioning is crucial to avoid tension on the anastomosis. Our novel modification of the Minerva orthosis is a useful adjunct in the postoperative management of these patients.

Clinical relevance
This modified pediatric Lerman Minerva CTO is a useful adjunct to protect the anastomosis following CTR or TR.
Postoperative Patient Reported Outcomes After Cholesteatoma Surgery
Authors: ten Tije Fleur A. , Pauw Robert Jan , Bom Steven J. H. , Stam Mariska , Kramer Sophia E. , Lissenberg-Witte Birgit I. , Merkus Paul 
Published: March 2022

Background:
Results and success measures of cholesteatoma surgery are generally described using objective data whereas subjective data are mostly lacking. Patients experiences and complaints are becoming more important alongside clinical and audiometric outcome measures in cholesteatoma care.

Objective:
To investigate the course of patient-reported complaints, the impact of complaints, audiometric measures and the stability of audiometric measures, and complaints over time after primary and recurrent/residual cholesteatoma surgery.

Methods:
Postoperative patients were prospectively included and divided into primary acquired and recurrent/residual cholesteatoma. The EuroQol 5D (EQ-5D-3L), Otology Questionnaire Amsterdam (OQUA), and the Speech Spatial Questionnaire (SSQ) were completed by 144 patients up to 2 years postoperative. Patient-reported complaints divided in eight separate domains, postoperative hearing and impact on daily life were longitudinally assessed by means of linear mixed models.

Results:
Hearing loss and tinnitus are the most reported postoperative complaints over time. Patient-reported loss of taste and the impact of all complaints decline over time. All other patient-reported complaints remain stable over time, only itch complaints fluctuate. Primary cholesteatoma patients score significantly higher on hearing loss complaints compared with recurrent/residual patients although they have comparable mean audiometric hearing loss. Furthermore, pure-tone hearing threshold, instead of asymmetric hearing loss, is correlated with the localization domain of the SSQ.

Conclusion:
This study provides important insights in the course of complaints and its impact on daily life after cholesteatoma surgery. Overall, the postoperative patient-reported complaints after cholesteatoma surgery are generally low in the studied population.
Brief Report: Heterogeneous Preferences for Care Engagement Among People With HIV Experiencing Homelessness or Unstable Housing During the COVID-19 Pandemic
Authors: Imbert Elizabeth , Hickey Matthew D. , Del Rosario Jan Bing , Conte Madellena , Kerkhoff Andrew D. , Clemenzi-Allen Angelo , Riley Elise D. , Havlir Diane V. , Gandhi Monica 
Published: March 2022

Background/Setting:
In San Francisco, HIV viral suppression is 71% among housed individuals but only 20% among unhoused individuals. We conducted a discrete choice experiment at a San Francisco public HIV clinic to evaluate care preferences among people living with HIV (PLH) experiencing homelessness/unstable housing during the COVID-19 pandemic.

Methods:
From July to November 2020, we conducted a discrete choice experiment among PLH experiencing homelessness/unstable housing who accessed care through (1) an incentivized, drop-in program (POP-UP) or (2) traditional primary care. We investigated 5 program features: single provider vs team of providers; visit incentives ($0, $10, and $20); location (current site vs current + additional site); drop-in vs scheduled visits; in-person only vs optional telehealth visits; and navigator assistance. We estimated relative preferences using mixed-effects logistic regression and conducted latent class analysis to evaluate preference heterogeneity.

Results:
We enrolled 115 PLH experiencing homelessness/unstable housing, 40% of whom lived outdoors. The strongest preferences were for the same provider (β = 0.94, 95% CI: 0.48 to 1.41), visit incentives (β = 0.56 per $5; 95% CI: 0.47 to 0.66), and drop-in visits (β = 0.47, 95% CI: 0.12 to 0.82). Telehealth was not preferred. Latent class analysis revealed 2 distinct groups: 78 (68%) preferred a flexible care model, whereas 37 (32%) preferred a single provider.

Conclusions:
We identified heterogeneous care preferences among PLH experiencing homelessness/unstable housing during the COVID-19 pandemic, with two-thirds preferring greater flexibility and one-third preferring provider continuity. Telehealth was not preferred, even with navigator facilitation. Including patient choice in service delivery design can improve care engagement, particularly for marginalized populations, and is an essential tool for ending the HIV epidemic.
Solitary Nasopharyngeal Metastasis From Papillary Thyroid Carcinoma Shown on FDG PET/CT
Authors: Xu Anqi , Jie Xiao , Xiu Yan , Shi Hongcheng 
Published: March 2022

Abstract
It is very rare for papillary thyroid cancer metastasize to nasopharynx. We report FDG PET/CT findings of a solitary nasopharyngeal metastasis from papillary thyroid cancer 4 decades after the initial diagnosis in a 66-year-old woman, which mimics nasopharyngeal carcinoma. The final diagnosis was confirmed by pathological examination from the biopsy of nasopharyngeal lesion.
Facial Flap Necrosis From COVID-19 Face Mask Precautions
Authors: Choi Melinda , Wo Luccie , Joshi Priyashma , Nugent Ajani , Thaller Seth R. 
Published: March 2022

Abstract:
Use of facial mask coverings has been a strong Centers for Disease Control and Prevention recommendation as an essential mitigation measure in the spread of the SARS-CoV-2 novel coronavirus (COVID)-19 virus. Face mask utilization has been shown to induce changes in the skin microclimate, especially around the perioral and perinasal regions. This results in increased mask adjustments and development of friction between masks and the underlying skin. The authors report novel findings of 2 individuals with skin cancer who underwent facial reconstruction during the COVID-19 pandemic. They encountered untoward sequelae of facial flap pressure necrosis due to the use of face mask coverings. These individuals were ultimately successfully treated with local wound care. One individual experienced auricular implant extrusion and flap loss. It is critical that reconstructive surgeons be aware of potential complications and the need for potential revision surgeries due to the use of face masks, and educate their patients to properly position the protective face masks based on the type of reconstruction performed. Plastic surgeons might also reconsider reconstructive management options in light of these additional obstacles.
The Effects of Occlusal Plane Inclination and Dental Decompensation on the Overall Result of Surgical Correction of Class II Malocclusion
Authors: Seker Elif Dilara , Sunal Akturk Ezgi , Yerli Burcu , Coban Gokhan , Kucukkeles Nazan 
Published: March 2022

Purpose:
To evaluate the effects of upper occlusal plane (UOP) inclination and incisor decompensations on the outcome of surgical Class II patients.

Materials and Methods:
Pretreatment (T0), preoperative (T1), and posttreatment (T2) cephalograms of 30 surgical Class II patients were included. Cephalometric measurements were performed using the Dolphin Imaging Software in this retrospective study. The differences between time points were analyzed with repeated measures ANOVA. Spearman correlation test was used to determine any correlations between either the UOP alterations or incisor decompensations and the cephalometric variables.

Results:
A significant improvement was obtained in the sagittal skeletal, dental variables, and soft tissue B point. Significant correlations were found between the decompensation achievement ratio and the change of the convexity angle. The relative percentage ratio (RPR) of the lower incisor was correlated with Wits appraisal, ANB, and Convexity Angle at the T2 stage. The RPR of the upper incisor was found to be correlated with lip strain. The relative surgical correction ratio of the UOP angle was found to be correlated with the surgical change of Wits appraisal and convexity angle. The RPR of the UOP angle was correlated with the SNB, ANB, and SN-GOGN angles at the T2 stage.

Conclusions:
Significant improvement in the incisor inclinations was achieved, but the incisors were inadequately decompensated at the preoperative phase. Surgical correction was limited by the inadequate presurgical decompensation. The surgical alteration of the UOP should be taken into consideration for the surgical planning to obtain better outcomes for Class II patients.
Familial Clustering and Genetic Analysis of Severe Thumb Carpometacarpal Joint Osteoarthritis in a Large Statewide Cohort
Authors: Gavile Catherine M. , Kazmers Nikolas H. , Novak Kendra A. , Meeks Huong D. , Yu Zhe , Thomas Joy L. , Hansen Channing , Barker Tyler , Jurynec Michael J. 
Published: March 2022

AbstractObjectivesThe objectives of this study are to 1) identify individuals that required surgery for thumb carpometacarpal osteoarthritis (CMCJ OA), 2) determine if CMCJ OA clusters in multigenerational families, 3) define the magnitude of familial risk of CMCJ OA, 4) identify risk factors associated with CMCJ OA and 5) identify rare genetic variants that segregate with familial CMCJ OA.MethodsWe searched the Utah Population Database to identify a cohort of CMCJ OA patients that required a surgical procedure (CMC fusion or arthroplasty). Affected individuals were mapped to pedigrees to identify high-risk multigenerational families with excess clustering of CMCJ OA. Cox regression models were used to calculate familial risk of CMCJ OA in related individuals. Risk factors were evaluated using logistic regression models. Whole exome sequencing was used to identify a rare coding variant associated with familial CMCJ OA.ResultsWe identified 550 pedigrees with excess clustering of severe CMCJ OA. The relative risk of developing CMCJ OA requiring surgical treatment was significantly elevated in first- and third-degree relatives of affected individuals, and significant associations with advanced age, female sex, obesity, and tobacco use were observed. A dominantly segregating, rare variant in CHSY3 was associated with familial CMCJ OA.ConclusionsFamilial clustering of severe CMCJ OA was observed in a statewide population. Identification of a candidate gene indicates a genetic contribution to the etiology of the disease. Our data indicate the genetic and environmental factors contribute to the disease process, further highlighting the multifactorial nature of the disease.Key messagesWe study a unique cohort of individuals requiring surgical management of CMCJ OA.Severe CMCJ OA clusters in large, multigenerational families indicating a genetic contribution to the disease..We discovered a dominant coding variant in CHSY3 in a family with severe CMCJ OA.
SETBP1variants outside the degron disrupt DNA-binding and transcription independent of protein abundance to cause a heterogeneous neurodevelopmental disorder
Authors: Wong Maggie MK , Kampen Rosalie A , Braden Ruth O , Alagöz Gökberk , Hildebrand Michael S , Barnett Christopher , Barnett Meghan , Brusco Alfredo , Carli Diana , de Vries Bert BA , Dingemans Alexander JM , Elmslie Frances , Ferrero Giovanni B , Jansen Nadieh A , van de Laar Ingrid MBH , Moroni Alice , Mowat David , Murray Lucinda , Novara Francesca , Peron Angela , Scheffer Ingrid E , Sirchia Fabio , Turner Samantha J , Vignoli Aglaia , Vino Arianna , Weber Sacha , Chung Wendy K , Gerard Marion , López-González Vanessa , Palmer Elizabeth , Morgan Angela T , van Bon Bregje W , Fisher Simon E 
Published: March 2022

AbstractGermlinede novo SETBP1variants cause clinically distinct and heterogeneous neurodevelopmental disorders. Heterozygous missense variants at a hotspot encoding a canonical degron lead to SETBP1 accumulation and Schinzel-Giedion syndrome (SGS), a rare severe developmental disorder involving multisystem malformations. Heterozygous loss-of-function variants result inSETBP1haploinsufficiency disorder which is phenotypically much milder than SGS. Following an initial description of four individuals with atypical SGS carrying heterozygous missense variants adjacent to the degron, a few individual cases of variants outside the degron were reported. Due to the lack of systematic investigation of genotype-phenotype associations of different types ofSETBP1variants, and limited understanding of the roles of the gene in brain development, the extent of clinical heterogeneity and how this relates to underlying pathophysiological mechanisms remain elusive, imposing challenges for diagnosis and patient care. Here, we present a comprehensive investigation of the largest cohort to-date of individuals carryingSETBP1missense variants outside the degron (n=18, including one in-frame deletion). We performed thorough clinical and speech phenotyping with functional follow-up using cellular assays and transcriptomics. Our findings suggest that such variants cause a clinically and functionally variable developmental syndrome, showing only partial overlaps with classical SGS andSETBP1haploinsufficiency disorder, and primarily characterised by intellectual disability, epilepsy, speech and motor impairment. We provide evidence of loss-of-function pathophysiological mechanisms impairing ubiquitination, DNA-binding and transcription. In contrast to SGS andSETBP1haploinsufficiency, these effects are independent of protein abundance. Overall, our study provides important novel insights into diagnosis, patient care and aetiology of SETBP1-related disorders.
Therapeutic effects of Rosa Canina, Urtica Dioica and Tanacetum Vulgare Herbal Combination in Treatment of Tinnitus Symptoms; A Double-blind Randomized Clinical Trial
Authors: Khosravi Mohammad Hossein , Atefi Amirhomayoun , Mehri Afsaneh , Sodeifian Fatemeh , Yousefi Jaleh , Hagh Ali Bagheri , Sohrabpour Saeed , Kazemi Fatemeh , Ajalloueian Mohammad , Saeedi Masoumeh 
Published: March 2022

BackgroundTinnitus is defined as the perception of sound in the ear or head in the absence of an external stimulus for which we have no definite treatment. Neurotec® is a medication of herbal origin with IFDA approval. Previous studies showed the neuroprotective effect of Neurotec®. In this study we evaluated the effectiveness of Neurotec in improving tinnitus symptoms.MethodsThis double-blind randomized clinical trial was performed on patients with tinnitus. Patients received Neurotec 100 mg capsules (BID) or placebo for three months. Pure tone audiometry (PTA) was measured at 0.5, 1, 2, 4 and 6 KHz frequencies. Using a Tinnitus Handicap Inventory (THI) questionnaire, tinnitus loudness, daily annoyance, daily life or sleep disturbance, daily perception and mood alteration were evaluated.ResultsFinally, 103 (69 male and 34 female) patients with a mean age of 51.33±13.91 years were analyzed. There was no significant difference between the intervention (n=53) and the control group (n=50) regarding baseline symptoms before and one month after the intervention (P>0.05). While, they were significantly different three months after the intervention (P<0.05). The mean pure tone air and bone conduction were not significantly different between the control and the intervention group before and three months after the intervention at 0.5,1,2 and 4 kHz (P>0.05). The mean pure tone air conduction was not significantly different between the two groups before and three months after the intervention at 6 kHz (P>0.05).ConclusionA three-month treatment with Neurotec Capsules beside patient education can effectively control symptoms of patients with tinnitus.
Factors affecting zero-waste behaviors: Focusing on the health effects of microplastics
Authors: Choi Eun-Hi , Lee Hyunjin , Kang Mi-Jung , Nam Inwoo , Moon Hui-Kyeong , Sung Ji-Won , Eu Jae-Yun , Lee Hae-Bin 
Published: March 2022

AbstractMicroplastics harm human health. Therefore, the present study assessed the knowledge and attitude of university students towards reducing microplastic use and examined their zero-waste behaviors. Our results lay the foundation for program development aimed at promoting zero-waste activities. The study was conducted from August 20, 2021, to September 10, 2021, including students at a university in G metropolitan city. Questions were developed to verify how the use of disposables and the knowledge, attitude, and behaviors related to zero-waste were affected after the COVID-19 pandemic. A survey was conducted with 197 students, and the data of 196 students were analyzed. Family type (β=0.146, p=0.042) and usage of disposables (β=0.158, p=0.049) were the factors affecting zero-waste behavior in Model 1. In Model 2, which included the subcategory of zero-waste knowledge, the health effects of microplastics (β=0.197, p=0.008) and environmental preservation (β=0.236, p=0.001) were significant factors. In Model 3, which included the subcategory of zero-waste attitude, the health effects of microplastics (β=0.149, p=0.016), use of eco-friendly products (β=0.342, p<0.001), and environmental preservation (β=0.317, p<.001) were significant factors. Therefore, additional studies and education on the health effects of microplastics are warranted, and suitable alternatives for disposables must be developed.
Persistence of targetable lesions, predicted therapy sensitivity and proteomes through disease evolution in pediatric acute lymphoblastic leukemia
Authors: Lorentzian Amanda C. , Rever Jenna , Ergin Enes K. , Guo Meiyun , Akella Neha M. , Rolf Nina , Lim C. James , Reid Gregor S.D. , Maxwell Christopher A. , Lange Philipp F. 
Published: March 2022

ABSTRACTChildhood acute lymphoblastic leukemia (ALL) genomes show that relapses often arise from subclonal outgrowths. However, the impact of clonal evolution on the actionable proteome and response to targeted therapy is not known. Here, we present a comprehensive retrospective analysis of paired ALL diagnosis and relapsed specimen. Targeted next generation sequencing and proteome analysis indicated persistence of actionable genome variants and stable proteomes through disease progression. Paired viably-frozen biopsies showed high correlation of drug response to variant-targeted therapies butin vitroselectivity was low. Proteome analysis prioritized PARP1 as a new pan-ALL target candidate needed for survival following cellular stress; diagnostic and relapsed ALL samples demonstrated robust sensitivity to treatment with two PARP1/2 inhibitors. Together, these findings support initiating prospective precision oncology approaches at ALL diagnosis and emphasize the need to incorporate proteome analysis to prospectively determine tumor sensitivities, which are likely to be retained at disease relapse.STATEMENT OF SIGNIFICANCEWe discover that disease progression and evolution in pediatric acute lymphoblastic leukemia is defined by the persistence of targetable genomic variants and stable proteomes, which reveal pan-ALL target candidates. Thus, personalized treatment options in childhood ALL may be improved with the incorporation of prospective proteogenomic approaches initiated at disease diagnosis.
Topical anticholinergic medications for primary hyperhidrosis: A protocol for a systematic review and meta-analysis
Authors: Wu Yang , Gao Wenli , Yan Jiao , Yang Min , Gao Dongyang 
Published: March 2022

AbstractBackgroundPrimary hyperhidrosis (PHH) is a chronic condition characterized by excessive sweating. Several topical anticholinergic agents have been developed, but the evidence for the efficacy and tolerability of changing medication pathways of anticholinergics for PHH is limited. We will review the available literature to derive information regarding the efficacy and safety of different medicines used for the topical treatment of patients with hyperhidrosis.MethodsPubMed, Cochrane Library, Embase, Web of Science, and Cochrane Central Register of Controlled Trials will be searched from inception to May 2023 for studies that may be eligible for inclusion. Randomized controlled trials (RCTs) of PHH treated with topical anticholinergic drugs will be included in the analysis. The primary outcomes will include the severity of hyperhidrosis measured quantitatively, the Hyperhidrosis Disease Severity Scale (HDSS) score, or the proportion of subjects with a minimum 2-grade improvement from baseline in HDSS, the Hyperhidrosis Disease Severity Measure-Axillary (HDSM-Ax) score, and Dermatology Life Quality Index (DLQI). The secondary outcomes will focus on safety and tolerability. Study selection, data extraction, and assessment of the risk of bias will be independently performed by two investigators. Data synthesis will be performed using Review Manager 5.4 software.ResultsThe results will be published as a peer-reviewed article.ConclusionsThis review will systematically evaluate the existing evidence on the efficacy and safety of topical anticholinergic agents in the treatment of PHH. These conclusions will provide supporting evidence for the current guidelines and more reliable evidence-based medicine references for clinical practitioners and researchers.PROSPERO registration numberCRD42022312316