bluuebunny/crossref_metadata_2025_split huggingface dataset:
Six-Month Impairment in Cognition, Mental Health, and Physical Function Following COVID-19–Associated Respiratory Failure
Authors: Maley Jason H. , Sandsmark Danielle K. , Trainor Alison , Bass Geoffrey D. , Dabrowski Cian L. , Magdamo Brigid A. , Durkin Bridget , Hayes Margaret M. , Schwartzstein Richard M. , Stevens Jennifer P. , Kaplan Lewis J. , Mikkelsen Mark E. , Lane-Fall Meghan B. 
Published: March 2022

OBJECTIVES:
To determine the prevalence and extent of impairments impacting health-related quality of life among survivors of COVID-19 who required mechanical ventilation, 6 months after hospital discharge.

DESIGN:
Multicenter, prospective cohort study, enrolling adults 18 years old or older with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection who received mechanical ventilation for 48 hours or more and survived to hospital discharge. Eligible patients were contacted 6 months after discharge for telephone-based interviews from March 2020 to December 2020. Assessments included: Montreal Cognitive Assessment-Blind, Hospital Anxiety and Depression Scale, Impact of Event Scale-6, EuroQOL 5 domain quality-of-life questionnaire, and components of the Multidimensional Dyspnea Profile.

SETTING:
Two tertiary academic health systems.

PATIENTS:
Of 173 eligible survivors, a random sample of 63 were contacted and 60 consented and completed interviews.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Mean age was 57 + 13 years and mean duration of invasive mechanical ventilation was 14 + 8.2 days. Six months post-discharge, 48 patients (80%; 95% CI, 68–88%) met criteria for post-intensive care syndrome (PICS), with one or more domains impaired. Among patients with PICS, 28 (47%; 95% CI, 35–59%) were impaired in at least 2 domains, and 12 (20%; 95% CI, 12–32%) impaired in all three domains. Significant symptoms of post-traumatic stress were present in 20 patients (33%; 95% CI, 23–46%), anxiety in 23 (38%; 95% CI, 27–51%), and depression in 25 (42%; 95% CI, 30–54%). Thirty-three patients (55%; 95% CI, 42–67%) had impairments in physical activity; 25 patients (42%; 95% CI, 30–54%) demonstrated cognitive impairment.

CONCLUSIONS:
Eighty percent of COVID-19 survivors who required mechanical ventilation demonstrated PICS 6 months after hospital discharge. Patients were commonly impaired in multiple PICS domains as well as coexisting mental health domains.
SIBLING CONCORDANCE IN SYMPTOM ONSET AND ATROPHY GROWTH RATES IN STARGARDT DISEASE USING ULTRA-WIDEFIELD FUNDUS AUTOFLUORESCENCE
Authors: Heath Jeffery Rachael C. , Thompson Jennifer A. , Lo Johnny , Lamey Tina M. , McLaren Terri L. , De Roach John N. , Azamanov Dimitar N. , McAllister Ian L. , Constable Ian J. , Chen Fred K. 
Published: March 2022

Purpose:
To investigate concordance in symptom onset, area of dark autofluorescence (DAF), and growth rate (GR) between Stargardt disease siblings at an age-matched time point.

Methods:
In this retrospective longitudinal study of sibling pairs with identical biallelic ABCA4 variants, age at symptom onset, best-corrected visual acuity, atrophy area, and effective radius of DAF on ultra-widefield fundus autofluorescence were recorded. Absolute intersibling differences for both eyes were compared with absolute interocular differences using the Mann–Whitney test.

Results:
Overall 39 patients from 19 families were recruited. In 16 families, age-matched best-corrected visual acuity and DAF were compared between siblings. In 8 families, DAF GR was compared. The median (range) absolute difference in age at symptom onset between siblings was 3 (0–35) years. Absolute intersibling differences in age-matched best-corrected visual acuity were greater than interocular differences (P = 0.01). Similarly, absolute intersibling differences in DAF area and radius were greater than interocular differences (P = 0.04 for area and P = 0.001 for radius). Differences between absolute interocular and intersibling GR were not statistically significant (P = 0.44 for area GR and P = 0.61 for radius GR).

Conclusion:
There was significant discordance in age-matched best-corrected visual acuity and DAF beyond the expected limits of interocular asymmetry. Lack of significant intersibling differences in GR warrants further investigation.
OPHTHALMIC ARTERY OCCLUSION AS THE PRESENTING SIGN OF ACQUIRED IMMUNODEFICIENCY SYNDROME
Authors: Miller Charles G. , Carroll Robert M. 
Published: March 2022

Background/Purpose:
The purpose of this study was to describe a case of severe occlusive vasculitis that led to a diagnosis of AIDS in a previously healthy middle-aged man.

Methods:
Multimodal imaging including widefield fundus photography, spectral domain optical coherence tomography, and widefield fluorescein angiography was performed.

Results:
A healthy 46-year-old man presented with sudden onset vision loss in his left eye with an afferent pupillary defect. His examination revealed signs of retinal vascular disease in both eyes, with an ophthalmic artery occlusion in his affected left eye and a hemiretinal vein occlusion in his asymptomatic right eye. An extensive medical workup was significant for HIV positivity; he was ultimately diagnosed with AIDS, and ocular findings were attributed to an associated occlusive vasculitis. He developed anterior segment neovascularization in the left eye for which he received intravitreal bevacizumab and panretinal photocoagulation. He ultimately required cyclophotocoagulation in the left eye for poorly controlled intraocular pressure in the setting of neovascular glaucoma.

Conclusion:
Although HIV is most classically associated with a retinal microangiopathy, testing should be considered in cases of occlusive retinal vasculitis because it is a rare cause of such findings.
Calcineurin-fusion facilitates Cryo-EM Structure Determination of a Family A GPCR
Authors: Xu Jun , Chen Geng , Wang Haoqing , Cao Sheng , Heng Jie , Deupi Xavier , Du Yang , Kobilka Brian K. 
Published: March 2022

AbstractAdvances in singe-particle cryo-electron microscopy (cryo-EM) have made possible to solve the structures of numerous Family A and Family B G protein coupled receptors (GPCRs) in complex with G proteins and arrestins, as well as several Family C GPCRs. Determination of these structures has been facilitated by the presence of large extra-membrane components (such as G protein, arrestin, or Venus flytrap domains) in these complexes that aid in particle alignment during processing of the cryo-EM data. In contrast, determination of the inactive state structure of Family A GPCRs is more challenging due to the relatively small size of the seven transmembrane domain (7TM) and to the surrounding detergent micelle that, in the absence of other features, make particle alignment impossible. Here we describe an alternative protein engineering strategy where the heterodimeric protein calcineurin is fused to a GPCR by three points of attachment, the cytoplasmic ends of TM5, TM6 and TM7. This three-point attachment provides a more rigid link with the GPCR transmembrane domain that facilitates particle alignment during data processing, allowing us to determine the structures of the β2 adrenergic receptor (β2AR) in the apo, antagonist-bound, and agonist-bound states. We expect that this fusion strategy may have broad application in cryo-EM structural determination of other Family A GPCRs.
Managing conflicts to improve the retail networks in China: replication research with extensions
Authors: Chen Shu-Ching 
Published: March 2022

PurposeThis study provides an insight into and a solution for the conflict among marketing channel members in China. It also examines the application of a Western channel conflict management (CM) model in China and suggests future research directions for CM of marketing channel members.Design/methodology/approachA replication research study with extensions was conducted following previous studies' suggestions. Using a Chinese sample, the author further evaluates a Western conceptual framework with hypothetical relationships of variables. Different from the original study using students in a simulated network environment, this study used channel members involved in actual network activities. Data were collected by a questionnaire survey and analyzed.FindingsThe results show CM of channel members in China and do not fully support the hypotheses in the Western model. This study identifies the determinants of an effective approach toward resolving conflicts among members from the perspectives of network outcomes, conflict types and management styles. The choice of CM style is imperative to member performance, especially for achieving specific network outcomes or CM goals.Originality/valueThis study contributes to existing studies of CM of marketing channel members by providing empirical evidence of managing conflict of members in the Chinese channel, revealing the effectiveness of CM of members with different cultural norms, providing managers with practical solutions to effectively manage conflicts among members and providing future research directions regarding this topic.
Intergroup dynamics in post-merger integration process
Authors: Thelisson Anne-Sophie , Meier Olivier 
Published: March 2022

PurposeIntergroup dynamics between the acquirer and the acquired are determinants of post-merger integration success. Mergers and acquisitions scholars call for the adoption of new reading prisms to gain deeper insights on post-merger integration dynamics as the failure rate of mergers remains high. In mobilizing works from social psychology to examine intergroup dynamics, this study aims to respond to this call by shedding light on the post-merger integration process. Typologies of integration processes do not take into account intergroup dynamics that operate within the new entity, which are influencing the decision-making process. To better understand how firms achieve a successful integration (symbiosis), the authors propose a processual analysis of intergroup dynamics in post-merger integration.Design/methodology/approachThe research approach is a qualitative, longitudinal enquiry, which allows us to examine intergroup dynamics in two real-time merger case studies. The integration processes selected for this research include symbiotic integrations. Both integration processes were analyzed over two years, starting with the merger agreement.FindingsThis study sheds additional light on the triggers for achieving symbiosis integration by demonstrating the specific role and contribution of each of the parties (majority and minority) during the process. This study shows that post-merger is a process that follows different steps to reach symbiosis, involving majority/minority dynamics. The symbiosis implies minority innovation by adopting new business and organizational practices, mainly inspired by the standards and values of the minority. The study highlights innovation by the minority as a key element in achieving a symbiotic integration. This element can be understood by managers involved in managing the integration as a turning point in the integration process.Research limitations/implicationsThe authors investigated symbiotic integration in specific industries; questions can arise about the extent to which findings are transferable to other mergers and acquisitions contexts.Originality/valueThis study advances the understanding of the dynamics between the majority and minority in adopting a processual and longitudinal analysis. On that point, this study gains insights on the “black box” that represents post-merger integration process.
Privileged core-state migrant entrepreneurs in Poland: an ethnic economy in reverse?
Authors: Girling Richard Andrew 
Published: March 2022

PurposeThe study aims to explore migrant entrepreneurship in a hitherto overlooked demographic, namely, migrants who have moved away from core-states and towards an economically less developed area. In particular, the study aims to critically evaluate to what extent mainstream theories and findings regarding migrants' ethnic division of labour are applicable in such an “upside down” migratory context.Design/methodology/approachThe study qualitatively analyses 41 privileged core-state (UK, USA and Germany, among others) migrant entrepreneurs who have migrated to Wroclaw, Poland, and positions these findings against a second subject group of 24 migrant entrepreneurs from periphery-states (namely, Ukraine and Belarus).FindingsThe study finds that, while the situations of the periphery-state subject group largely lend support to the mainstream literature of migrant entrepreneurship, for those from the core-states subject group it is an altogether different story, whereby these migrants were found to be less likely to employ co-ethnic labour and, instead, were more likely to opt for native, Polish labour.Research limitations/implicationsThe study's findings begin to question the universality of migrant entrepreneurship theories which have been formulated within mainstream (semi-)periphery-to-core dominant-subordinate contexts. This, in turn, carries implications for policymakers outside of core-states who may need to carefully consider if such theories are applicable to their specific contexts.Originality/valueThis study not only helps to address a gap in the literature surrounding migrant entrepreneurship within Poland but also a gap within the wider literature in terms of migrant entrepreneurship outside of core-state contexts.
If tomorrow never comes: the impact of anxiety, materialism and attitude on consumption behavior in a pandemic
Authors: Mishra Anubhav , Indwar Radha Govind , Samu Sridhar 
Published: March 2022

Purpose
This research aims to examine the impact of consumers’ anxiety on the three types of consumption activities (sharing, hoarding and regular buying) during the coronavirus pandemic. Further, it aims to investigate the moderating role of materialism on anxiety and how attitude toward the pandemic affects consumers’ consumption behavior.

Design/methodology/approach
An online survey was conducted to test the proposed research model. The data were analyzed using SmartPLS and PROCESS tools.

Findings
Higher levels of anxiety lead to less sharing and more hoarding of resources but do not impact consumers’ regular buying intentions. A positive attitude toward an external event such as lockdown and intrinsic materialism can help individuals to cope with the anxiety successfully. Furthermore, consumers are more likely to share and less likely to hoard when they develop a positive attitude toward pandemic.

Research limitations/implications
Future research can explore the role of health-efficacy and attitude toward health as coping strategy toward pandemic. A longitudinal research can explore the gradual changes in consumers’ attitudes and consumption behavior.

Practical implications
Governments, marketers and policymakers should focus on reducing consumers’ anxiety and to build a positive attitude toward pandemic to avoid the issues of hoarding and enable sharing of resources with others.

Originality/value
This study contributes to the literature on terror management theory and crisis management during a pandemic using a consumption context.
Realization path of social capital “exit from virtual to real”: evidence from China
Authors: Xu Shulin , Wan Xue , Li Yunfeng , Yan Jingrui 
Published: March 2022

PurposeHow to realize social capital “exit from virtual to real” has become not only a hot issue that elicited economists' and the practice field's concern but also a key economic structure problem that the government has to solve urgently. The main purpose of this study is to explore effective methods for social capital to “exit from virtual to real”.Design/methodology/approachThe study investigates the realization path of social capital's “exit from virtual to real” by using firm theory and data from the National Bureau of Statistics in China. Provincial panel data are also utilized to empirically test the impact of social capital's de-realization to virtual (or from virtual to real) on economic development and whether the path of social capital “from virtual to real” is valid.FindingsThis study analyzes the development status of social funds serving the real economy and the hazards of social funds' “exit from real to virtual,” which are mainly viewed as eroding the development of the real economy and causing operating difficulties. On the basis of firm theory, the internal motivation for why social funds flow to the real economy is explored from the perspectives of the needs of the real economy, price and profit. Moreover, this study designs a path for returning social capital to the real economy.Practical implicationsOverall, expanding aggregate demand while providing an effective supply and implementing a proactive fiscal policy that focuses on structural tax cuts while keeping margins in the virtual economy are appropriate for promoting the competitiveness of the real economy.Originality/valueThis study explores a topic, namely, social capital “exit from virtual to real,” that has received little attention. It provides an in-depth discussion of the following questions. (1) What is the current situation of social capital serving the real economy? (2) What kind of harm can social capital bring to society? What are the inherent barriers to the flow of social capital to the real economy? (3) At this stage, how can the effective transformation of social capital into the real economy be realized? The findings help in understanding the sustainable entrepreneurship concept, particularly in developing countries.
Effects of social capital of social networking site on social identity and continuous participant behavior
Authors: Wang Edward Shih-Tse , Lin Hung-Chou , Liao Yu-Ting 
Published: March 2022

PurposeThe paper focuses on social capital as the characteristic of social groups that promote coordination; moreover, social identity plays a key role in the construction of group relationships. However, few research studies have looked at how the social capital of social networking sites (SNSs) is related to the social identity of its members. Drawing on social capital and social identity theory, this study investigated the effects of SNS social capital (shared language, social trust and network density) on social identity and continuous participation. The mediating role of social identity was also investigated.Design/methodology/approachIn total, 444 SNS members volunteered to participate in this study. Structural equation modeling was applied to analyze a conceptual model.FindingsThe results revealed that SNS social trust and network density directly and significantly affected the social identity and continuous participation behavior of members. SNSs using a shared language positively affected social identity, but this was not directly associated with continuous participation behavior.Originality/valueBecause the network externalities of SNSs exert critical effects on user benefits, attracting continuous user participation remains one of the critical challenges for SNS administrators. Both the theoretical and practical implications of this study can aid SNS administrators in developing effective continuous participation strategies.Peer reviewThe peer-review history for this article is available at: https://publons.com/publon/10.1108/OIR-07-2021-0369
A multiobjective mathematical model to form the best team at sports clubs: team harmony and player performance objectives
Authors: Budak Gerçek , Kara İmdat 
Published: March 2022

Purpose
Team coaches of sports clubs are highly concerned when forming the best team to win the upcoming match at the stage before that particular game. Even if a team squad is comprising of a limited number of players, the combination of them makes a complicated problem with a huge number of possible line-ups. This study aims to build a mathematical model to solve this problem with the objectives of maximum player performance and team harmony.

Design/methodology/approach
This paper proposes a novel approach of a multiobjective mathematical model on team harmony and player performance. Two objectives are chosen as these are the most important perspectives that define the best team. The model outputs are nondominated solutions of these two objectives.

Findings
These solutions are displayed to the team coach to decide the best team according to strategical, psychological and conditional preferences of him/her. A real-life example is demonstrated to show the model validity and interpretation of the results by using the technique for order preference by similarity to an ideal solution on a volleyball team formation problem.

Originality/value
This paper proposes a multiobjective mathematical model on team harmony and player performance to solve the team coach’s hard and complicated problem.
Bevacizumab plus dacomitinib combination therapy for L858R‐mutated metastatic lung adenocarcinoma: A report of two cases
Authors: Teng Chi‐Kang , Chen Chieh‐Lung , Chen Ting‐Han , Cheng Wen‐Chien , Tu Chih‐Yen 
Published: March 2022

AbstractDual inhibition of the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor pathways for the treatment for EGFR‐mutated, metastatic non‐small cell lung cancer is supported by previous randomized controlled trials. However, the use of second‐generation irreversible EGFR tyrosine kinase inhibitor (TKI) dacomitinib in combination with antiangiogenic therapy has not been reported in the literature. Here, we report the case of a 73‐year‐old man who presented with hemoptysis and dyspnea on exertion and was diagnosed with right upper lung adenocarcinoma with pleural metastasis and L858R mutation. The second case is of a 60‐year‐old woman who presented with low back pain and was diagnosed with right lower lung adenocarcinoma with bone metastasis and L858R mutation. Both patients underwent first‐line therapy with the TKI dacomitinib in combination with bevacizumab. The first patient showed a nearly complete response, and the second patient showed a partial response after the combination therapy and no severe side effects.