bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flame Spray Pyrolysis as a Synthesis Platform to Assess Metal Promotion in In2O3‐Catalyzed CO2 Hydrogenation
Authors: Pinheiro Araújo Thaylan , Morales‐Vidal Jordi , Zou Tangsheng , García‐Muelas Rodrigo , Willi Patrik O. , Engel Konstantin M. , Safonova Olga V. , Faust Akl Dario , Krumeich Frank , Grass Robert N. , Mondelli Cecilia , López Núria , Pérez‐Ramírez Javier 
Published: February 2022

AbstractA plethora of metal promoters have been applied to enhance the performance of In2O3 in CO2 hydrogenation to methanol, a prospective energy carrier. However, the lack of systematic catalyst preparation and evaluation precludes a direct comparison of their speciation and promotional effects, and consequently, the design of an optimal system. Herein, flame spray pyrolysis (FSP) is employed as a standardized synthesis method to introduce nine metal promoters (0.5 wt.%) into In2O3. Methanol productivity generally increased on M‐In2O3 with selectivity following Pd ≈ Pt > Rh ≈ Ru ≈ Ir > Ni ≈ Co > Ag ≈ In2O3 > Au. In‐depth characterization, kinetic analyses, and theoretical calculations reveal a range of metal‐dependent speciation which dictate catalyst architecture and degree of promotion. Atomically‐dispersed promoters (Pd, Pt, Rh, Ru, and Ir) grant the highest improvement in performance, particularly Pd and Pt, which markedly promote hydrogen activation while hindering undesired CO formation. In contrast, metals in clustered (Ni and Co) and nanoparticle (Ag and Au) forms display moderate and no promotion, respectively. This study provides an atomic‐level understanding of In2O3 promotion based on a unified protocol, and highlights the potential of FSP to engineer complex catalytic systems toward more efficient energy transformations.
Paget‐Schroetter syndrome from manual handling at work: Case report and review of the literature
Authors: Heo Jaeyeong , Medani Khalid , Juma Haitham 
Published: February 2022

AbstractPaget‐Schroetter syndrome (PSS) is a primary deep venous thrombosis of the subclavian‐axillary vein complex occurring after repetitive and strenuous use of the shoulders and arms. Here, we report the case of a 24‐year‐old man who presented with left subclavian and axillary vein thrombosis after loading and unloading labor, who was diagnosed with PSS confirmed with Doppler ultrasound, and treated with anticoagulation. By comparing our case with 45 published case reports, we also aim to analyze patient characteristics, diagnostic methods, and treatment options for the disorder.
Operational Detection of Entanglement via Quantum Designs
Authors: Yan Xin , Liu Ye‐Chao , Shang Jiangwei 
Published: February 2022

AbstractFrom an operational point of view, several new entanglement detection criteria are proposed using quantum designs. These criteria are constructed by considering the correlations defined with quantum designs. Counter‐intuitively, the criteria with more settings are exactly equivalent to the corresponding ones with the minimal number of settings, namely the symmetric informationally complete positive operator‐valued measures (SIC POVMs). Fundamentally, this observation highlights the potentially unique role played by SIC POVMs in quantum information processing. Experimentally, this provides the minimal number of settings that one should choose for detecting entanglement. Furthermore, it is found that nonlinear criteria are not always better than linear ones for the task of entanglement detection.
ATP‐Induced Emergent Circularly Polarized Luminescence and Encryption
Authors: Fan Huahua , Li Kun , Tu Tao , Zhu Xuefeng , Zhang Li , Liu Minghua 
Published: February 2022

AbstractBiomimetic ATP‐driven supramolecular assembly is important to understand various biological processes and dissipative systems. Here, we report an ATP‐driven chiral assembly exhibiting circularly polarized luminescence (CPL) via the interaction of an achiral terpyridine‐based ZnII complex with nucleotides. It was found that while the metal complexes could co‐assemble with the nucleotides to form fluorescent assemblies, only a combination of furan‐substituted terpyridine complex and ATP showed an intense CPL with a dissymmetry factor (glum) as high as 0.20. This means that the complex could recognize ATP using CPL as a readout signal, thus providing an example of ATP encryption. Interestingly, when ATP was transferred into ADP or AMP under enzymatic hydrolysis, the CPL decreases or disappears. Addition of ATP generates CPL again, thus producing an ATP‐induced CPL system. This work presents the first example of ATP‐induced CPL and encryption.
Secondary metabolite‐entrapped, anti‐GPA33 targeted poly‐dopamine nanoparticles and their effectiveness in cancer treatment
Authors: Akbal Vural Oznur , Yaman Yesim Tugce , Abaci Serdar 
Published: February 2022

AbstractIn this study, the development of polydopamine nanoparticle (p‐Dop NP) as a drug carrier system for saponin (Sap) and its use in in vitro targeted cancer therapy was investigated. The average diameter of p‐Dop NP was found as 130 nm with a zeta potential of −18 mV and demonstrated high stability even after 6 weeks. The Sap release and cytotoxicity studies were carried out to reveal the effectiveness of the proposed carrier system. The offered approach demonstrated a high loading capacity of Sap as 81% with a sustainable and controlled release of 75%. To prevent the interaction of the anti‐cancer Sap with other healthy tissue and to enhance the targeting of DLD‐1 cells, anti‐GPA33 was immobilized onto the nanoparticle surface via carbodiimide strategy. The anti‐GPA33 and Sap loaded p‐Dop NPs demonstrated enhanced toxicity and cellular uptake compared to untargeted Sap loaded NPs as expected. The offered carrier system revealed simple and efficient targeted cancer therapy ability in vitro and may provide new ideas for the design of targeted delivery systems in the future.
Antiproliferative evaluations of triazoloquinazolines as classical DNA intercalators: Design, synthesis, ADMET profile, and molecular docking
Authors: Eissa Ibrahim H. , Ibrahim Mohamed‐Kamal , Alesawy Mohamed S. , El‐Adl Khaled 
Published: February 2022

AbstractNovel triazoloquinazolines were designed and synthesized and evaluated as anticancer agents against HepG2 and HCT‐116 cells. The biological testing data corresponded well to those of the molecular docking studies. The HCT‐116 cell line was most affected due to the actions of our derivatives. Derivative 7a was the most potent one against both HepG2 and HCT116 cells, with IC50 = 7.98 and 5.57 µM, respectively. This compound showed anticancer activity that was nearly equipotent to that of doxorubicin against HepG2 cells, but higher than that of doxorubicin against HCT116 cells (IC50 = 7.94 and 8.07 µM, respectively). Compounds 8, 7b, and 6f showed excellent anticancer activities against both the HCT116 and HepG2 cell lines. The highly active compounds 6f, 7a, 7b, and 8 were evaluated for their DNA‐binding activities. Compounds 7a and 8 showed the highest binding activities. These derivatives potently intercalate in DNA, at IC50 values of 42.90 and 48.13 µM, respectively. Derivatives 6f and 7b showed good DNA‐binding activities, with IC50 values of 54.24 and 50.56 µM, respectively. Furthermore, in silico calculated ADMET profiles were established for our four highly active derivatives, in comparison to doxorubicin. Our derivatives 6f, 7a, 7b, and 8 showed a very good ADMET profile. Compounds 6f, 7a, 7b, and 8 follow Lipinski's rules, while doxorubicin violates three of these rules.
Okavango River Bridge in Botsuana, Afrika – steile Zähne am Delta
Authors: Grassl Martin , Benz Thomas 
Published: February 2022

AbstractDer Fluss Okavango im afrikanischen Botsuana mündet in ein inländisches Delta. Die dadurch entstehenden fruchtbaren Gebiete bilden die Grundlage für den einmaligen Artenreichtum der Flora und Fauna – ein Anziehungspunkt für Touristen aus aller Welt. Um die Erschließung des nordöstlichen Teils des Deltas zu erleichtern, wurde entschieden, die bestehende Fährverbindung durch eine feste Brückenverbindung als Schrägseilbrücke zu ersetzen. Die Pylone wurden, um den Symbolcharakter des Bauwerks zu unterstreichen, in einer speziellen Gestaltungsidee als A‐Pylone in der Form von sich kreuzenden Elefantenzähnen entworfen. Dieser Beitrag beschreibt die Entwurfsgeschichte sowie die Umsetzung des Sondervorschlags der Ausführung mit seinen wichtigen Details. Die Bauausführung erfolgt vor Ort seit dem Jahre 2018. Die feierliche Eröffnung und die Verkehrsfreigabe erfolgen ungefähr zeitgleich mit dem Erscheinen der vorliegenden Ausgabe der Bautechnik. Das Bauwerk wird einen wesentlichen Beitrag zur Verbesserung und Entwicklung der Infrastruktur des Okavango‐Deltas leisten.
Eco‐friendly nonconjugated polymer dots for chemiluminometric determination of 4‐nitrophenol
Authors: Haghighi Shishavan Yalda , Amjadi Mohammad 
Published: February 2022

AbstractPolymer dots (PDs) are a new family of quantum dots for which their behavior and potential applications have not yet been completely explored. In this study, nonconjugated PDs were synthesized using a simple pyrolysis method and used for the chemiluminescence (CL) assay of 4‐nitrophenol (4‐NP). PDs increased the CL signal of the Ce(IV)–Na2SO3 reaction 39‐fold. Using the CL spectrum, it was concluded that the emission at 434 nm was generated by excited PDs (PDs*), which are produced by energy transfer from SO2* to PDs. Our experiments showed that 4‐NP enhanced the CL signal of the Ce(IV)–Na2SO3–PDs reaction. The mechanism of this effect was explored by obtaining CL, ultraviolet–visible, and Fourier transform infrared spectra. Due to the high sensitivity and selectivity of the CL system for 4‐NP, a probe was designed to determine 4‐NP in the linear range 1.0–500 nmol/L with a detection limit of 0.33 nmol/L. Different spiked real samples were successfully analyzed using this probe.
Adaptive multi‐degree‐of‐freedom in situ bioprinting robot for hair‐follicle‐inclusive skin repair: A preliminary study conducted in mice
Authors: Zhao Wenxiang , Chen Haiyan , Zhang Yi , Zhou Dezhi , Liang Lun , Liu Boxun , Xu Tao 
Published: February 2022

AbstractSkin acts as an essential barrier, protecting organisms from their environment. For skin trauma caused by accidental injuries, rapid healing, personalization, and functionality are vital requirements in clinical, which are the bottlenecks hindering the translation of skin repair from benchside to bedside. Herein, we described a novel design and a proof‐of‐concept demonstration of an adaptive bioprinting robot to proceed rapid in situ bioprinting on a full‐thickness excisional wound in mice. The three‐dimensional (3D) scanning and closed‐loop visual system integrated in the robot and the multi‐degree‐of‐freedom mechanism provide immediate, precise, and complete wound coverage through stereotactic bioprinting, which hits the key requirements of rapid‐healing and personalization in skin repair. Combined with the robot, epidermal stem cells and skin‐derived precursors isolated from neonatal mice mixed with Matrigel were directly printed into the injured area to replicate the skin structure. Excisional wounds after bioprinting showed complete wound healing and functional skin tissue regeneration that closely resembling native skin, including epidermis, dermis, blood vessels, hair follicles and sebaceous glands etc. This study provides an effective strategy for skin repair through the combination of the novel robot and a bioactive bioink, and has a promising clinical translational potential for further applications.
Surgical site infection following minimally invasive lobectomy: Is robotic surgery superior?
Authors: Hou Yucheng , Hu Yeyan , Song Weijian , Zhang Jianfeng , Luo Qingquan , Zhou Qianjun 
Published: February 2022

AbstractBackgroundSurgical site infection (SSI) in thoracic surgery remains a significant cause of morbidity and prolonged hospitalization. Minimally invasive surgery (MIS) has significantly reduced the risk of SSI. We intended to compare whether there was difference between video‐assisted thoracic surgery (VATS) and robotic‐assisted thoracic surgery (RATS) in SSI and highlight possible factors influencing SSI in lobectomy.MethodsThis retrospective study analyzed patients who underwent minimally invasive lobectomy from January 2018 to December 2019. All patients' clinical characteristics and surgery‐related information which may be related to the likelihood of SSI were recorded.ResultsA total of 1231 patients' records were reviewed with 806 VATS and 425 RATS. SSI was classified as deep or superficial SSI. Eighty‐six (7.0%) patients were found to develop an SSI with 62 patients having deep infections and 24 had superficial infection. No statistical difference in the incidence rate and category of SSI was observed between patients undergoing VATS and RATS.ConclusionsThere was no difference in the incidence of SSI between VATS and RATS lobectomy. Male gender, heavy smoking, uncontrolled diabetes mellitus, body mass index (BMI) > 27.9, more blood loss, and the higher National Healthcare Safety Network (NHSN) risk index score (1 or 2) were the independent risk factors of SSI following minimally invasive lobectomy, while male gender, uncontrolled diabetes mellitus, BMI > 27.9, more blood loss and the higher NHSN risk index score (1 or 2) were the main predictors of deep SSI.
Isolation, Characterization and in Silico Studies of Secondary Metabolites from Jurinea macrocephala DC. with Antiproliferative Activity
Authors: Gürbüz Perihan , Doğan Şengül Dilem , Gündüz Miyase Gözde , Uzun Kübra , Uzunhisarcıklı Ebru , Yerer Mükerrem Betül 
Published: February 2022

AbstractIn the present work, cytotoxic potential of Jurinea macrocephala DC. (Asteraceae) was evaluated on A549 lung cancer and MCF‐7 breast cancer cell lines. Isolation studies were carried out using various and repetitive chromatographic methods in order to determine the phytochemical profile of the extracts. These studies led to the identification of twelve compounds; four triterpenes (1–4) and eight flavonoids (5–12). Spectroscopic examination (1D and 2D NMR, ESI‐MS) and comparison with relevant literature data were used to deduce the structures of all isolated molecules. To rationalize the obtained cytotoxicity data against breast cancer cell lines, the isolated compounds were docked into the binding site of aromatase, an important target enzyme for the treatment of breast cancer. Molecular docking studies revealed that flavonoids without sugar moieties (5–8) showed the best binding affinities. Overall, these mentioned compounds turned out to be also the most appropriate oral drug candidates after the calculation of their Lipinski parameters.
Asperbenzophenone A and Versicolamide C, New Fungal Metabolites from the Soft Coral Derived Aspergillus sp. SCSIO 41036
Authors: Long Jieyi , Pang Xiaoyan , Lin Xiuping , Liao Shengrong , Zhou Xuefeng , Wang Junfeng , Yang Bin , Liu Yonghong 
Published: February 2022

AbstractTwo new compounds, asperbenzophenone A (1) and versicolamide C (5), together with fifteen known compounds were isolated from a soft coral derived fungus Aspergillus sp. SCSIO 41036. Their structures were elucidated by spectroscopic methods, ECD analysis, and by a comparison with data from the literature. In bioassay, compound 8 showed significant inhibitory activity against lipopolysaccharide‐inducted nitric oxide (NO) in RAW264.7 cells at the concentration of 10 μM. Additionally, the anti‐acetylcholinesterase activity assay showed that 14 exhibited weak inhibition with an IC50 value of 157.8 μM.
Three New Aglain Derivatives from Aglaia odorata Lour. and Their Cytotoxic Activities
Authors: Wu Pan‐Feng , Liu Juan , Li Ya‐Nan , Ding Ru , Tan Rong , Yang Xiao‐Meng , Yu Yan , Hao Xiao‐Jiang , Yuan Chun‐Mao , Yi Ping 
Published: February 2022

AbstractThree new aglain derivatives (1–3), one known aglain derivative (4), two known rocaglamide derivatives (5 and 6), four known triterpenoids (7–10), and three steroids (11–13) were isolated from Aglaia odorata Lour. Their structures were established through the analysis of detailed spectroscopic data and electronic circular dichroism calculations. Five compounds (1 and 4–7) exhibited cytotoxic activities on human leukemia cells (HEL) and human breast cancer cells with IC50 values in the range of 0.03–8.40 μM. In particular, the cytotoxicity of compound 5 was six times stronger than that of the positive control (adriamycin) in HEL cell lines.
COVID‐19 vaccine‐induced Radiation Recall Dermatitis: Report of a case
Authors: Sepaskhah Mozhdeh , Ansari Asl Fatemeh , Taheri Mehrnoosh , Akbarzadeh Jahromi Mojgan 
Published: February 2022

AbstractRadiation Recall Dermatitis (RRD) is an inflammatory process in the site of irradiation, induced by physical and medical agents. Few cases of RRD in the skin and lung have been reported after COVID‐19 vaccination. Here, we report radiation recall dermatitis after both doses of inactivated SARS‐CoV‐2 vaccine (Sinopharm, China).
Heterostructure‐Regulated Metal Silicates Composite Material for Enhancing the Lithium‐Ion Batteries Performance
Authors: He Lanqi , Wang Qiushi , Feng Jin , Xie Zezhong , Zhou Junyi , Fei Fei 
Published: February 2022

AbstractNoticeable surface reaction in the energy storage mechanism has attracted tremendous research due to its relationship with electrochemical capacity and rate capability. In this work, in‐situ grown heterostructured metal silicates are prepared through a facile hydrothermal method. The composites are employed as anodes for supercapacitor and lithium‐ion batteries (LIBs). The ratio of cobalt and copper in the heterostructure has a significant effect on its properties, including porosity, electrical conductivity, and pseudo‐capacitance contribution during the energy storage process. The combination of metal silicates, heterostructure, and porous bio‐mass derived carbon into one system results in a unique electrode material with optimized reaction kinetics. The integration leads to a superior capacity and rate capability. Specifically, the cobalt silicate/copper silicate heterostructure composites present improved electrochemical performance as anode for LIBs and supercapacitor. For lithium‐ion storage, the B‐C@CoCuSi‐(3‐1) delivers a capacity of 574.5 mAh g−1. When used as an anode material for supercapacitor, the B‐C@CoCuSi‐(1‐3) shows a capacitance of 80.4 F g−1.
Synthesis and Photophysical Properties of 1,1,4,4‐Tetracyanobutadienes Derived from Ynamides Bearing Fluorophores**
Authors: Philippe Clotilde , Bui Anh Thy , Beau Maxime , Bloux Hugo , Riobé François , Mongin Olivier , Roisnel Thierry , Cordier Marie , Paul Frédéric , Lemiègre Loïc , Trolez Yann 
Published: February 2022

Abstract1,1,4,4‐Tetracyanobutadienes (TCBDs) bearing a large diversity of fluorophores were prepared following a multi‐step synthesis. In a crucial last step, all compounds were obtained from the corresponding ynamides, which were particularly suitable for the formation of the TCBDs in the presence of tetracyanoethylene via a [2+2] cycloaddition/retroelectrocyclization step (CA‐RE). Several fluorenyl derivatives in addition to phenanthrenyl and terphenyl ones provided ynamide‐based TCBDs affording remarkable emission properties covering a large range of wavelengths. Those compounds emit both in solid state and in solution from the visible region to the NIR range, depending on the molecular structures. Quantum yields in cyclohexane reached unforeseen values for such derivatives, up to 7.8 %. A huge sensitivity to the environment of the TCBDs has also been unraveled for most of the compounds since we observed a dramatic fall of the quantum yields when changing the solvent from cyclohexane to toluene, while they are almost non‐emissive in dichloromethane.
Multidrug Idebenone/Naproxen Co‐loaded Aspasomes for Significant in vivo Anti‐inflammatory Activity
Authors: d'Avanzo Nicola , Cristiano Maria Chiara , Di Marzio Luisa , Bruno Maria Chiara , Paolino Donatella , Celia Christian , Fresta Massimo 
Published: February 2022

AbstractThe use of proper nanocarriers for dermal and transdermal delivery of anti‐inflammatory drugs recently gained several attentions in the scientific community because they pass intact and accumulate payloads in the deepest layers of skin tissue. Ascorbyl palmitate‐based vesicles (aspasomes) can be considered a promising nanocarrier for dermal and transdermal delivery due to their skin whitening properties and suitable delivery of payloads through the skin. The aim of this study was the synthesis of multidrug Idebenone/naproxen co‐loaded aspasomes for the development of an effective anti‐inflammatory nanomedicine. Aspasomes had suitable physicochemical properties and were safe in vivo if topically applied on human healthy volunteers. Idebenone/naproxen co‐loaded aspasomes demonstrated an increased therapeutic efficacy of payloads compared to the commercially available Naprosyn® gel, with a rapid decrease of chemical‐induced erythema on human volunteers. These promising results strongly suggested a potential application of Idebenone/naproxen multidrug aspasomes for the development of an effective skin anti‐inflammatory therapy.
Ambient air exposures to arsenic and cadmium and overall and prostate cancer–specific survival among prostate cancer cases in Pennsylvania, 2004 to 2014
Authors: McDonald Alicia C. , Gernand Jeremy , Geyer Nathaniel R. , Wu Hongke , Yang Yanxu , Wang Ming 
Published: February 2022

BackgroundExposures to arsenic (As) and cadmium (Cd) have been associated with higher prostate cancer (PC) mortality; however, these associations have been inconsistent. The authors investigated whether higher ambient air concentrations of As and Cd are associated with lower overall and PC‐specific survival among PC cases in Pennsylvania.MethodsIncident PC cases of patients, aged 40 years or older, with a clinical diagnosis and nonmetastatic disease were identified in the 2004 to 2014 Pennsylvania Cancer Registry. Demographic, clinical, and pathologic information were extracted from the Pennsylvania Cancer Registry. The 3‐ and 5‐year average and cumulative air concentrations of As and Cd were extracted from the Environmental Protection Agency's Toxics Release Inventory database. Spatial‐temporal hierarchical accelerated failure time models were used to examine the associations between air concentrations of As and Cd and overall and PC‐specific survival for the total population and stratified by geographical region defined by rurality and Appalachia status, after adjusting for confounders.ResultsThere were 78,914 PC cases included. Increasing 3‐ and 5‐year average and cumulative air concentrations of As and Cd were significantly associated with lower overall and PC‐specific survival among cases, after adjusting for confounders, for the total population, and stratified by geographical region for most of the estimates.ConclusionsData suggest that increasing ambient air exposures to As and Cd may play a role in overall and PC‐specific mortality risk among PC cases. Exposures to As and Cd are modifiable and may provide insight into potential strategies to improve PC health outcomes.Lay Summary

Arsenic and cadmium exposures linked to increased prostate cancer deaths remain unclear.

We investigated whether air levels of arsenic and cadmium reported to be released from industries decrease overall and prostate cancer–specific survival among prostate cancer cases identified in the 2004 to 2014 Pennsylvania Cancer Registry.

Among the 78,914 prostate cancer cases, increasing air levels of arsenic and cadmium are found to be associated with lower overall and prostate cancer–specific survival for the total population and within rural and urban Appalachia and urban non‐Appalachia counties in Pennsylvania.

Reducing exposures to arsenic and cadmium have the potential to decrease prostate cancer deaths.