bluuebunny/crossref_metadata_2025_split huggingface dataset:
All-dielectric metasurfaces with high Q-factor Fano resonances enabling multi-scenario sensing
Authors: Chen Xueer , Zhang Yong , Cai Guoxiong , Zhuo Jianliang , Lai Kunzhong , Ye Longfang 
Published: September 2022

Abstract
We propose and numerically demonstrate high Q-factor sensors based on all-dielectric metasurfaces, which are very sensitive to the change of the refractive index of the surrounding media and the incident angle. By using the light incident angular scanning method, the all-dielectric metasurface based on symmetric tetramer can act as an excellent sensing platform for trace-amount molecules such as protein A/G, 2, 4-DNT, and 2D material graphene with huge absorbance enhancement in the mid-infrared broadband spectrums. The results reveal that envelope of absorbance amplitudes is in good agreement with the vibrational mode of molecules, and absorbance enhancement factors reach as high as 10 dB in the mid-infrared wavelength range from 5.75 to 6.80 μm. To further increase the Q-factor of the resonances, the all-dielectric metasurface based on asymmetric tetramer is investigated. This asymmetric structure can induce toroidal and magnetic dipoles governed by quasi-BIC to produce multi-extremely narrow linewidth Fano resonances, and the maximum sensitivity reaches up to 1.43 μm/RIU. Therefore, the proposed all-dielectric metasurface demonstrates highly enhanced performance in refractive index and chemical information sensing for trace-amount biomolecules, which inspires the development of new high-sensitivity refractive index sensors for the nondestructive identification in the mid-infrared regime.
Animal waste antibiotic residues and resistance genes: A review
Authors: Wang Yi , Shetty B. Dharmaveer , Kuppu Sundaram , Pandey Pramod K. 
Published: September 2022

Abstract
Antibiotic resistance is an emerging risk for human and animal health, and mitigating the risk requires an improved understanding of various sources of risks and identifying the level of threats for each source. Many antibiotics are currently used against pathogens for treating infections in animals and humans, and it is considered that antibiotic resistance genes (ARGs) acquired by pathogens may have an environmental origin. Because of contamination in ambient waterways, it is likely that ARGs may affect both organic and non-organic farming. While health risk as a consequence of ARGs is difficult to determine because of lack of understanding of dose-response, the presence of ARGs in human waste and animal manure, and the subsequent application of these organic wastes as fertilizers has a potential of spreading ARGs in the environment. Additional research is needed to understand the presence, growth, and transport of ARGs through animal wastes such as dairy manure. In this review, we focus on synthesizing information regarding the occurrence of ARGs in dairy manure, potential transport pathways, and factors responsible for the spread of ARGs in the environment. Besides, we also explore potential treatment methods that may contribute to the ARG removal in dairy manure and help alleviate ARG contamination.
Deviant language in the literary dialogue: An English–Romanian translational view
Authors: Arhire Mona 
Published: September 2022

Abstract
Drawing on the scholarly acknowledgement regarding the experimental nature of dialogue in Modern and Postmodern literature, this article attempts at investigating the translatability of dialogic utterances displaying deviant language. The relevance of the study is given by the structural differences between languages, which oftentimes triggers the impossibility of rendering the dialogic information relative to the literary characters’ identity in the target language. The examples are depicted from several fictional texts, where part of the characters’ identity is constructed by the peculiarities of their speech which deviates, in a range of manners, from standard English. Such deviant language indicates the characters’ idiolectal, sociolectal or dialectal identity, as well as the broader social context in which they act. The examination of deviant language leads to findings concerning its structural variety and its essential role in completing some literary characters’ identity and, implicitly, its importance in translation. Solutions are suggested to the interlingual transfer of formally untranslatable deviant language of a grammatical, phonological and lexical nature, taking also account of criteria pertaining to functional aspects. The conclusions discuss structural, phonological and lexical possibilities of the target language, the translator’s creative engagement in the translation of deviant identity-marking language and suggest further research opportunities.
The Debye–Scherrer technique – rapid detection for applications
Authors: Mueller Eckehard 
Published: September 2022

Abstract
The Debye–Scherrer (DS) technique is a common technique for determining spacings in atomic layers by X-ray diffraction. The spacings of the atomic layers are proportional to the macroscopic stress in the radiated area. When a crystalline powder is irradiated with X-rays, the diffracted X-rays produce a ring that photographic films detect. Afterward, the film is developed to reveal the rings. Earlier, this procedure took lots of time. With upcoming multiple wavelength anomalous dispersion-detectors, a very sensitive area detector, DS rings can be detected and analyzed in minutes. This allows for the rapid determination of residual stresses prior to inspection in a production environment. Additional information from the intensity distribution within the ring can be obtained. A description of the new technique is given.
Looking at HMI Concepts for Highly Automated Vehicles: Permanent vs. Context-Adaptive Information Presentation
Authors: Hollander Cornelia , Hartwich Franziska , Krems Josef F. 
Published: September 2022

Abstract
To facilitate the usage and expected benefits of higher-level automated vehicles, passengers’ distrust and safety concerns should be reduced through increasing system transparency (ST) by providing driving-related information. We therefore examined the effects of ST on passengers’ gaze behavior during driving, trust in automated driving and evaluation of different human-machine interface (HMI) concepts. In a driving simulator, 50 participants experienced three identical highly automated drives under three HMI conditions: no HMI (only conventional speedometer), context-adaptive HMI (all system information only available in more complex situations) or permanent HMI (all system information permanently available). Compared to driving without HMI, the introduction of the two HMIs resulted in significantly higher usage of the center stack display (i.e. gazes towards the HMIs), which was accompanied by significantly higher trust ratings. The considerable differences in information availability provided by the context-adaptive versus permanent HMI did not reflect in similarly considerable differences regarding the passengers’ gaze behavior or accompanied trust ratings. Additionally, user experience evaluations expressed preferences for the context-adaptive HMI. Hence, the permanent HMI did not seem to create benefits over the context-adaptive HMI, supporting the usage of more economical, context-adaptive HMIs in higher-level automated vehicles.
Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion
Authors: Emre Bostanci Meriç , Hepokur Ceylan , Caner Armağan , Can Mollaoğlu Murat , Karadayi Kürşat 
Published: September 2022

Abstract

Objectives
Mesenteric ischemia is a surgical emergency caused by poor blood supply to the intestines. In ischemia, the decrease in blood flow to the tissue causes acidosis and cell death through anaerobic metabolism. Clinoptilolite is one of the most abundant natural zeolites, and it is used for its ion exchange and adsorbent properties. Clinoptilolite has been reported to have an immune-enhancing, anti-carcinogenic, and antioxidant effect in-vitro/in-vivo studies. Clinoptilolite’s histological and biochemical effects on ischemic small intestines.

Methods
The experimental animals were randomly divided into sham, control, and clinoptilolite treatment group. Clinoptilolite was administered intraperitoneally after ischemia/reperfusion. Cardiac blood was stored for biochemical analysis. Total antioxidant levels and total oxidant levels were analyzed from the sera taken from groups. Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) expressions in blood samples were determined by RT-qPCR. At the end of the reperfusion, terminal ileum tissues were taken for histological tests.

Results
The mean TNF-α expression level was 3.89 in the control group and 2.91 in the clinoptilolite treatment group. The mean IL-6 expression levels were 2.32 in the control group and 1.49 in the clinoptilolite treatment group.

Conclusions
clinoptilolite administration provided healing in the rat ischemia-reperfusion injury model.
Magnesium-rich intermetallic compounds RE
3Ag4Mg12 (RE = Y, La–Nd, Sm–Dy, Yb) and AE
3Ag4Mg12 (AE = Ca, Sr)
Authors: Reimann Maximilian Kai , Klenner Steffen , Gerdes Josef Maximilian , Hansen Michael Ryan , Pöttgen Rainer 
Published: September 2022

Abstract
The magnesium-rich intermetallic compounds RE
3Ag4Mg12 (RE = Y, La–Nd, Sm–Dy, Yb) and AE
3Ag4Mg12 (AE = Ca, Sr) were synthesized from the elements in sealed tantalum ampoules through heat treatment in an induction furnace. X-ray powder diffraction studies confirm the hexagonal Gd3Ru4Al12 type structure, space group P63/mmc. Three structures were refined from single crystal X-ray diffractometer data: a = 973.47(5), c = 1037.19(5) pm, wR2 = 0.0296, 660 F
2 values, 30 variables for Gd3Ag3.82(1)Mg12.18(1), a = 985.27(9), c = 1047.34(9) pm, wR2 = 0.0367, 716 F
2 values, 29 variables for Yb3Ag3.73(1)Mg12.27(1) and a = 992.41(8), c = 1050.41(8) pm, wR2 = 0.0373, 347 F
2 values, 28 variables for Ca3Ag3.63(1)Mg12.37(1). Refinements of the occupancy parameters revealed substantial Ag/Mg mixing within the silver-magnesium substructure, a consequence of the Ag@Mg8 coordination. The alkaline earth and rare earth atoms build Kagome networks. Temperature dependent magnetic susceptibility measurements indicate diamagnetism/Pauli paramagnetism for the compounds with Ca, Sr, Y and YbII, while the others with the trivalent rare earth elements are Curie-Weiss paramagnets. Most compounds order antiferromagnetically at T

N
= 4.4(1) K (RE = Pr), 34.6(1) K (RE = Gd) and 23.5(1) K (RE = Tb) while Eu3Ag4Mg12 is a ferromagnet (T

C
= 19.1(1) K). 151Eu Mössbauer spectra confirm divalent europium (δ = −9.88(1) mm s−1). Full magnetic hyperfine field splitting (18.4(1) T) is observed at 6 K. Yb3Ag4Mg12 shows a single resonance in its 171Yb solid state NMR spectrum at 6991 ppm at 300 K indicating a strong, positive Knight shift.
Optimization of Preparation Conditions of F-N-TiO2/AC Composite Photocatalyst for Degradation of Printing and Dyeing Wastewater
Authors: Chen Zhen , Chen Geng , Guo Xiujuan , Lu Yu , Zhu Yingying 
Published: September 2022

Abstract
A novel composite photocatalyst loading titanium dioxide particles onto activated carbon and co-doping with fluorine and nitrogen (F-N-TiO2/AC) was synthesized using the impregnation-hydrothermal method for the degradation of printing and dyeing wastewater. The optimal preparation conditions of the composite photocatalyst were determined using orthogonal experiments. Through range analysis and variance analysis, the optimal preparation conditions were as follows: a molar ratio of anhydrous ethanol, glacial acetic acid, and tetrabutyl titanate of 3:175:100, and hydrothermal temperature of 150°C and hydrothermal time of 12 h. The catalyst prepared under these conditions showed high catalytic activity, with 100 % degradation of methyl orange when irradiated with a xenon lamp light source for 60 min, and the preparation conditions were feasible. The F-N-TiO2/AC composite photocatalysts were characterized using x-ray diffraction and nitrogen adsorption–desorption measurements. On the basis of this analysis, it was found that the doping of fluorine and nitrogen did not change the anatase structure of titanium dioxide but affected the grain growth and changed the structural properties of the F-N-TiO2/AC photocatalyst. Good reusability properties were also found.
A importância da papiloscopia na identificação de vítimas de acidentes de massa
Authors: Oliveira Santos Barbara Francine 
Published: September 2022

Acidente de massa é um evento de grande magnitude e natureza singular cujas vítimas podem ser encontradas em diferentes condições. A identificação papiloscópica de um corpo conservado é um procedimento simples que fornece resultados rápidos. Entretanto, corpos que sofreram danos físico-químicos e alcançaram estágios mais avançados de decomposição são mais difíceis de identificar em razão da má conservação tecidual. Realizou-se um levantamento bibliográfico com o objetivo de elucidar a aplicabilidade da papiloscopia para a identificação de quatro diferentes tipos de vítimas fatais de acidentes de massa. Constatou-se que a identificação positiva das vítimas nesses casos se dá pela escolha da melhor técnica para coletar e analisar o material papiloscópico, a partir da identificação dos danos sofridos, ajudando inclusive a reconstruir e identificar a natureza do acidente, sendo utilizada também para a investigação criminal.
Real-life efficacy and predictors of response to immunotherapy in pituitary tumors: a cohort study
Authors: Ilie Mirela Diana , Villa Chiara , Cuny Thomas , Cortet Christine , Assie Guillaume , Baussart Bertrand , Cancel Mathilde , Chanson Philippe , Decoudier Bénédicte , Deluche Elise , Di Stefano Anna Luisa , Drui Delphine , Gaillard Stephan , Goichot Bernard , Huillard Olivier , Joncour Anthony , Larrieu-Ciron Delphine , Libe Rossella , Nars Guillaume , Vasiljevic Alexandre , Raverot Gérald 
Published: September 2022

Abstract

Objective
After temozolomide failure, no evidence-based treatment is available for pituitary carcinomas (PCs) and aggressive pituitary tumors (APTs). To date, only 12 cases treated with immune-checkpoint inhibitors (ICIs) have been published, showing encouraging efficacy. Predictive factors of response are lacking. Here, we aimed to assess the real-life efficacy and predictors of response to ICIs in PCs and APTs.

Design and methods
This study is a multicentric, retrospective, observational cohort study, including all PCs and APTs treated with ICIs in France up to March 2022. PD-L1 immunohistochemistry and CD8+ T cell infiltration were evaluated centrally.

Results
Six PCs (four corticotroph and two lactotroph) and nine APTs (five corticotroph and four lactotroph) were included. The real-life efficacy of ICIs was lower than previously published data. Three corticotroph tumors (33.3%) showed partial response, one (11.1%) stable disease, while five (55.6%) progressed. One lactotroph tumor (16.7%) showed partial response, one (16.7%) stable disease, while four (66.7%) progressed. PCs responded far better than APTs, with 4/6 PCs showing partial response compared to 0/9 APTs. Corticotroph tumors responded slightly better than lactotroph tumors. In the four responsive corticotroph tumors, PD-L1 staining was negative and CD8+ T cell infiltration attained a maximum of 1% in the tumor center.

Conclusions
Confirmation of the presence or absence of metastases is necessary before starting ICIs. After temozolomide failure, ICIs appear as a good therapeutic option for PCs, especially for corticotroph carcinomas. Negative PD-L1 staining and very low CD8+ T cell infiltration in the tumor center should not preclude ICI administration in corticotroph carcinomas.

Significance statement
This is the first study to assess the real-life efficacy of ICIs in pituitary carcinomas (PCs) and aggressive pituitary tumors. We also assessed potential predictors of response and are the first to assess the predictive value of CD8+ cell infiltration. We identified the tumor type as a major predictor, ICIs proving far more effective in treating PCs. Our study provides evidence that ICIs are a good option after temozolomide failure for PCs (four of six responded), especially for corticotroph carcinomas (three of four responded). We also provide evidence that negative PD-L1 staining and very low CD8+ cell infiltration in the tumor center should not preclude ICI administration in corticotroph carcinomas. Moreover, our findings point toward the need to systematically perform extension workup before starting ICIs.
OXIDATIVE STRESS AND REPRODUCTIVE FUNCTION: Reactive oxygen species in the mammalian pre-implantation embryo
Authors: Deluao Joshua C , Winstanley Yasmyn , Robker Rebecca L , Pacella-Ince Leanne , Gonzalez Macarena B , McPherson Nicole O 
Published: September 2022

In brief
Reactive oxygen species are generated throughout the pre-implantation period and are necessary for normal embryo formation. However, at pathological levels, they result in reduced embryo viability which can be mediated through factors delivered by sperm and eggs at conception or from the external environment.

Abstract
Reactive oxygen species (ROS) occur naturally in pre-implantation embryos as a by-product of ATP generation through oxidative phosphorylation and enzymes such as NADPH oxidase and xanthine oxidase. Biological concentrations of ROS are required for crucial embryonic events such as pronuclear formation, first cleavage and cell proliferation. However, high concentrations of ROS are detrimental to embryo development, resulting in embryo arrest, increased DNA damage and modification of gene expression leading to aberrant fetal growth and health. In vivo embryos are protected against oxidative stress by oxygen scavengers present in follicular and oviductal fluids, while in vitro, embryos rely on their own antioxidant defence mechanisms to protect against oxidative damage, including superoxide dismutase, catalase, glutathione and glutamylcysteine synthestase. Pre-implantation embryonic ROS originate from eggs, sperm and embryos themselves or from the external environment (i.e. in vitro culture system, obesity and ageing). This review examines the biological and pathological roles of ROS in the pre-implantation embryo, maternal and paternal origins of embryonic ROS, and from a clinical perspective, we comment on the growing interest in combating increased oxidative damage in the pre-implantation embryo through the addition of antioxidants.
Inhibition of METTL5 improves preimplantation development of mouse somatic cell nuclear transfer embryos
Authors: Zhang Luchun , Yuan Meng , Huang Xingwei , Cao Qianzi , Huang Shaogang , Sun Ruizhen , Lei Lei 
Published: September 2022

In brief
Several factors affect the reprogramming efficiency of nuclear transfer embryos. This study shows that inhibiting 18S rRNA m6A methyltransferase METTL5 during nuclear transfer can improve the developmental rate of nuclear transfer embryos.

Abstract
N6-methyladenosine (m6A) is one of the most important epigenetic modifications in eukaryotic RNAs, which regulates development and diseases. It is identified by several proteins. Methyltransferase-like 5 (METTL5), an enzyme that methylates 18S rRNA m6A, controls the translation of proteins and regulates pluripotency in embryonic stem cells. However, the functions of METTL5 in embryonic development have not been explored. Here, we found that Mettl5 was upregulated in somatic cell nuclear transfer (SCNT) embryos compared with normal fertilized embryos. Therefore, we hypothesized that METTL5 knockdown during the early stage of SCNT would improve the developmental rate of SCNT embryos. Notably, injection of Mettl5 siRNA (si-Mettl5) into enucleated oocytes during nuclear transfer increased the rate of development and the number of cells in blastocysts. Moreover, inhibition of METTL5 reduced the activity of phosphorylated ribosomal protein S6, decreased the levels of the repressive histone modification H3K27me3 and increased the expression of activating histone modifications H3K27ac and H3K4me3 and mRNA levels of some 2-cell-specific genes. These results expand our understanding of the role of METTL5 in early embryonic development and provide a novel idea for improving the efficiency of nuclear transfer cloning.
Análisis del costo marginal para toma de decisiones en empresas del sector industrial
Authors: Restrepo-Morales Jorge Aníbal , Vanegas López Juan Gabriel , Pérez Quintero Natalia 
Published: September 2022

The aim of this paper is to make an analysis of marginal costs for the industrial sector of Dosquebradas (Risaralda). It is developed to determine the incidence of marginal costs for business decision making; first, an economic analysis of marginal costs and their application in plant size investment decisions for an industrial sector is developed; likewise, an accounting and financial analysis of marginal costs is developed for their application at the firm level in sales price and break-even point decisions.

Regarding the design and method of the study, a sample of four companies of the analyzed sector, which reported information to DANE by the Annual Manufacturing Survey of 2020. The data were analyzed using Montecarlo Simulation and lineal regression under an explanatory methodology.
As findings, the overall data show the minimum marginal cost achieved is 103.3 million and the maximum value is 325.2 million, which is the marginal cost range that allows demand management and production capacity.
The research exposes limitations that reveal a path for the future. First, the work uses data from DANE as the only source of information. Second, the sample size by sector differ in size and this makes analysis difficult. Finally, executives are very suspicious of cost information and only one company agreed to provide specific information with summary reserve.
The results reveal practical implications for MSMEs owners and managers and offer insight into the influence of marginal cost in maintaining MSMEs competitiveness.
The contribution of this work lies in demonstrating the importance of marginal cost to support decision making in MSMEs and the underlying opportunity to improve competitiveness, through the application of analysis methods available for such business units, which, despite their potential, have been little applied in this business segment.
Turismo de observação de cetáceos no Brasil
Authors: Gomes Rosany Rossi Pereira , Lunardi Vitor de Oliveira , Lunardi Diana Gonçalves 
Published: September 2022

Este estudo visa investigar o turismo de observação de cetáceos no Brasil, a partir de um levantamento de suas áreas de ocorrência, espécies-chave e normas e regulamentos vigentes. A metodologia inclui uma ampla revisão bibliográfica sobre áreas de ocorrência de cetáceos no Brasil, turismo de observação, instrumentos legais e códigos de conduta para o ordenamento desta atividade. Foi realizada uma busca por áreas de referência do turismo de observação de cetáceos em homepage de agências e operadoras de turismo. A coleta de dados se deu por meio de contato telefônico, e-mail e redes sociais das agências e operadoras de turismo. Neste estudo, foram identificadas sete espécies de cetáceos-chave do turismo de observação, 29 áreas de referência, com 79% dessas áreas inseridas em Unidades de Conservação. Os resultados deste estudo poderão subsidiar ações de monitoramento e fiscalização do turismo de observação de cetáceos, visando seu ordenamento e a proteção desses animais.