bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vision loss caused by immunoglobulin G4–related disease of the skull base complicated by a mucocele of the sphenoid sinus
Authors: Detiger Sanne E. , Paridaens Dion , Verdijk Robert M. , van Laar Jan A.M. , Dammers Ruben , Monserez Dominiek A. , Nagtegaal A. Paul 
Published: March 2022

AbstractBackgroundImmunoglobulin G4‐related disease (IgG4‐RD) is a fibro‐inflammatory disorder and manifestation in de paranasal and sphenoid sinus is well recognized. In this patient, IgG4‐RD presented in an unusual manner with vision loss due to mucocele formation in the sphenoid sinus.Case DescriptionA 19‐year‐old man, with an unremarkable medical history, was referred with decreased vision in the left eye, headaches, and a sharp pain in the left orbit and ear. Compression of the left optic nerve due to a large mucocele caused papillary edema and emergency endoscopic marsupialization of the mucocele was performed. When the vision decreased again, a more extensive decompressing sphenoidotomy was performed. Histopathology showed IgG4‐RD. Despite dexamethasone, the lesion expanded to the anterior skull base and the patient required repeat endoscopic surgery. After 3 months, a decrease in smell and vision warranted for a fourth extensive endoscopic decompressing surgery, complicated by a cerebrospinal fluid leak. Prednisone and later rituximab were commenced. Unfortunately, the patient reported a complete loss of vision after 4 months of rituximab due to increased mass effect on the optic nerve. An extensive combined craniofacial‐endoscopic surgery was performed to remove the entire mucocele and to prevent further contralateral and intracranial progression. Methylprednisolone monthly was commenced to prevent further complications.DiscussionThis case illustrates that in therapy‐resistant sino‐orbital IgG4‐RD, extensive surgery might be necessary at an earlier stage. It may even be the only option to prevent irreversible damage to the surrounding tissues. A multidisciplinary approach in the management of sino‐orbital IgG4‐RD is therefore warranted.
Photoaffinity Capture Compounds to Profile the Magic Spot Nucleotide Interactomes**
Authors: Haas Thomas M. , Laventie Benoît‐Joseph , Lagies Simon , Harter Caroline , Prucker Isabel , Ritz Danilo , Saleem‐Batcha Raspudin , Qiu Danye , Hüttel Wolfgang , Andexer Jennifer , Kammerer Bernd , Jenal Urs , Jessen Henning J. 
Published: March 2022

AbstractMagic Spot Nucleotides (MSN) regulate the stringent response, a highly conserved bacterial stress adaptation mechanism, enabling survival under adverse external challenges. In times of antibiotic crisis, a detailed understanding of stringent response is essential, as potentially new targets for pharmacological intervention could be identified. In this study, we delineate the MSN interactome in Escherichia coli and Salmonella typhimurium applying a family of trifunctional photoaffinity capture compounds. We introduce MSN probes covering a diverse phosphorylation pattern, such as pppGpp, ppGpp, and pGpp. Our chemical proteomics approach provides datasets of putative MSN receptors both from cytosolic and membrane fractions that unveil new MSN targets. We find that the activity of the non‐Nudix hydrolase ApaH is potently inhibited by pppGpp, which itself is converted to pGpp by ApaH. The capture compounds described herein will be useful to identify MSN interactomes across bacterial species.
Steric Modulation of Spiro Structure for Highly Efficient Multiple Resonance Emitters
Authors: Qu Yang‐Kun , Zhou Dong‐Ying , Kong Fan‐Cheng , Zheng Qi , Tang Xun , Zhu Yuan‐Hao , Huang Chen‐Chao , Feng Zi‐Qi , Fan Jian , Adachi Chihaya , Liao Liang‐Sheng , Jiang Zuo‐Quan 
Published: March 2022

AbstractA multiple resonance thermally activated delayed fluorescence (MR‐TADF) molecule with a fused, planar architecture tends to aggregate at high doping ratios, resulting in broad full width at half maximum (FWHM), redshifting electroluminescence peaks, and low device efficiency. Herein, we propose a mono‐substituted design strategy by introducing spiro‐9,9′‐bifluorene (SBF) units with different substituted sites into the MR‐TADF system for the first time. As a classic steric group,SBFcan hinder interchromophore interactions, leading to high device efficiency (32.2–35.9 %) and narrow‐band emission (≈27 nm). Particularly, the shield‐like molecule,SF1BN, seldom exhibits a broadened FWHM as the doping ratio rises, which differs from the C3‐substituted isomer and unhindered parent emitter. These results manifest an effective method for constructing highly efficient MR‐TADF emitters through a spiro strategy and elucidate the feasibility for steric modulation of the spiro structure in π‐framework.
High‐Potential Cathodes with Nitrogen Active Centres for Quasi‐Solid Proton‐Ion Batteries
Authors: Shen Dongyang , Rao Apparao M. , Zhou Jiang , Lu Bingan 
Published: March 2022

AbstractAlthough proton‐ion batteries have received considerable attention owing to their reliability, safety, toxin‐free nature, and low cost, their development remains in the early stages because of lacking proper electrolytes and cathodes for facilitating a high output voltage and stable cycle performance. We present a novel cathode based on active nitrogen centre, which provides a flat discharge plateau at 1 V with a capacity of 115 mAh g−1 and excellent stability. Moreover, a quasi‐solid electrolyte was developed to overcome the issue of corrosion, broaden the potential window of the electrolyte, and prevent the active material from dissolving. While using the unique as‐developed electrolyte, the newly designed cathode retained 89.67 % of its original capacity after 2000 cycles. Finally, we demonstrated the excellent cycle performance of the as‐developed metal‐free, flexible, soft‐packed battery. Notably, even when a portion of the battery was cut off, it continued to function normally.
Light‐Enhanced Osmotic Energy Harvester Using Photoactive Porphyrin Metal–Organic Framework Membranes
Authors: Li Zhong‐Qiu , Zhu Guan‐Long , Mo Ri‐Jian , Wu Ming‐Yang , Ding Xin‐Lei , Huang Li‐Qiu , Wu Zeng‐Qiang , Xia Xing‐Hua 
Published: March 2022

AbstractHigh ion selectivity and permeability, as two contradictory aspects for the membrane design, highly hamper the development of osmotic energy harvesting technologies. Metal–organic frameworks (MOFs) with ultra‐small and high‐density pores and functional surface groups show great promise in tackling these problems. Here, we propose a facile and mild cathodic deposition method to directly prepare crack‐free porphyrin MOF membranes on a porous anodic aluminum oxide for osmotic energy harvesting. The abundant carboxyl groups of the functionalized porphyrin ligands together with the nanoporous structure endows the MOF membrane with high cation selectivity and ion permeability, thus a large output power density of 6.26 W m−2 is achieved. The photoactive porphyrin ligands further lead to an improvement of the power density to 7.74 W m−2 upon light irradiation. This work provides a promising strategy for the design of high‐performance osmotic energy harvesting systems.
Sustainable Thioetherification via Electron Donor–Acceptor Photoactivation Using Thianthrenium Salts
Authors: Cabrera‐Afonso María Jesús , Granados Albert , Molander Gary A. 
Published: March 2022

AbstractThe synthesis of sulfides has been widely studied because this functional subunit is prevalent in biomolecules and pharmaceuticals, as well as being a useful synthetic platform for further elaboration. Thus, various methods to build C−S bonds have been developed, but typically they require the use of precious metals or harsh conditions. Electron donor–acceptor (EDA) complex photoactivation strategies have emerged as versatile and sustainable ways to achieve C−S bond formation, avoiding challenges associated with previous methods. This work describes an open‐to‐air, photoinduced, site‐selective C−H thioetherification from readily available reagents via EDA complex formation that tolerates a wide range of different functional groups. Moreover, C(sp2)−halogen bonds remain intact using this protocol, allowing late‐stage installation of the sulfide motif in various bioactive scaffolds, while allowing yet further modification through more traditional C−X bond cleavage protocols. Additionally, various mechanistic investigations support the envisioned EDA complex scenario.
Achieving low‐thermal conductivity and high β phase in PVDF/PMMA blend foams via low‐pressure microcellular foaming
Authors: Weng Zhengsheng , Wu Minghui , Ren Qian , Li Wanwan , Zhu Xiuyu , Wang Long , Li Hui , Zheng Wenge 
Published: March 2022

AbstractPolyvinylidene fluoride (PVDF) foam exhibits wider applications than traditional foams such as polyethylene and polystyrene foams due to its good corrosion resistance, flame retardant and wide operating temperature range. However, PVDF is difficult to foam and rigorous operating conditions including high pressure and high temperature were unavoidably adopted to prepare PVDF foams. Herein, microcellular PVDF foam was successfully fabricated with the combination of adding polymethylmethacrylate (PMMA) and batch foaming at mild processing condition. Compared to the pure PVDF foam with a low‐expansion‐ratio of 1.1 times, the PVDF/PMMA (70/30) blend foam showed an expansion ratio as high as 20 times together with a small cell size of approximately 5 μm. Additionally, the prepared PVDF/PMMA blend foam exhibited a low‐thermal conductivity (0.039 w m−1 k−1) and high content of β‐phase crystal (95%), which shows promising application in areas like electronic devices, thermal insulation and packaging materials.
A chromosome‐level genome assembly of Paracymoriza distinctalis (Lepidoptera: Crambidae: Acentropinae)
Authors: Chen Xiaoning , Zhu Wenbo , Wang Biao , Wang Yuqi , You Ping 
Published: March 2022

AbstractParacymoriza distinctalis is a semiaquatic lepidopteran insect, which is of great value for studying the differentiation of the Pyraloidea superfamily. However, the understanding of heredity, evolution, and functional genomics of P. distinctalis are limited by few genome‐wide resources. Here, we applied PacBio sequencing and the chromosome capture technique to assemble the first P. distinctalis genome from a single female individual. The genome size is 1.2 Gb with 32 chromosomes and the N50 is 38.91 Mb. Approximately 576.37 Mb, accounting for 48.93% of the genome, was identified as repeats. The genome comprises 39,003 protein‐coding genes, 66.56% of which were functionally annotated. Comparative genomics analysis suggested that the common ancestor of P. distinctalis and Chilo suppressalis lived ~83.5 million years ago. This chromosome‐level genome assembly work is not only conducive to the understanding of P. distinctalis, but also may promote the study of the genomes of other lepidopteran species.
Biosynthesis of zerovalent iron nanoparticles for catalytic reduction of 4‐nitrophenol and decoloration of textile dyes
Authors: Anasdass Jaculin Raiza , Kannaiyan Pandian , Gopinath Subhash C.B. 
Published: March 2022

AbstractWe demonstrate a green chemistry approach to synthesize narrow‐sized zerovalent iron (nZVI) nanoparticles using Artocarpus heterophyllus Lam. leaf extract as reducing and capping agent. The produced nZVI was characterized by various instrumental methods including ultraviolet–visible spectra, transmission electron microscopy, vibrating sample magnetometer (VSM), X‐ray diffraction, and Fourier transform infrared spectroscopy. Based on the electron microscopy observations, the particle size was estimated to be ∼30 nm. In VSM, the saturation point of magnetization was observed to be 0.6 emu g−1 under a magnetic field of 0 ± 30 kOe. The synthesized nZVI was amorphous in nature as per the XRD results. The catalytic activity of the nZVI was employed for the catalytic reduction of 4‐nitrophenol (4‐NP) and decoloration of textile dyes such as methylene blue, methyl orange, and malachite green, respectively. The proposed nZVI synthesis method exhibited better catalytic performance toward reduction of 4‐NP and degradation of dyes within 4 min for 0.1 mg of catalyst. Moreover, the synthesized catalyst nZVI can be recoverable and reutilized in many cycles without loss of its significant catalytic activity. The synthesized nZVI could be a promising material to treat industrial wastewater via profitable, sustainable, and ecofriendly approaches.
Thermoluminescence dosimetric attributes of Yb3+‐doped BaO–ZnO–LiF–B2O3 glass material after Er3+ co‐doping
Authors: Prabhu Nimitha S. , Sharmila K. , Karunakara N. , Almousa Nouf , Sayyed M. I. , Kamath Sudha D. 
Published: March 2022

AbstractMotivated by our previous study on Sm3+ ions as thermoluminescence (TL) sensitizers to the BaO–ZnO–LiF–B2O3–Yb2O3 glass system, in the current study we examined the effect of Er3+ ion co‐doping on the TL characteristics of this glass system. The 4f–4f electronic transitions of the Er3+ and Yb3+ ions were confirmed via the optical absorption spectrum. Notably, the use of Yb3+–Er3+ ions failed to improve the TL intensity, sensitivity, and trap density. However, they enabled the glass system to function as an activator–quencher system. The linearity range and effective atomic number remained unaffected after co‐doping. In addition, the problem of anomalous fading caused a remnant signal of just 58% after a week of storage of the Yb3+ monodoped glass. This was resolved by the optimum co‐doping of Er3+ ions to achieve an 89% signal. The co‐doping of Er3+ ions to the BaO–ZnO–LiF–B2O3–Yb2O3 glass system regulated its thermal stability and therefore supplemented its potential for radiation monitoring in food processing and retrospective dosimetry.
Gut microbiome–micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?
Authors: Barone Monica , D'Amico Federica , Brigidi Patrizia , Turroni Silvia 
Published: March 2022

AbstractMicronutrients, namely, vitamins and minerals, are necessary for the proper functioning of the human body, and their deficiencies can have dramatic short‐ and long‐term health consequences. Among the underlying causes, certainly a reduced dietary intake and/or poor absorption in the gastrointestinal tract play a key role in decreasing their bioavailability. Recent evidence from clinical and in vivo studies suggests an increasingly important contribution from the gut microbiome. Commensal microorganisms can in fact regulate the levels of micronutrients, both by intervening in the biosynthetic processes and by modulating their absorption. This short narrative review addresses the pivotal role of the gut microbiome in influencing the bioavailability of vitamins (such as A, B, C, D, E, and K) and minerals (calcium, iron, zinc, magnesium, and phosphorous), as well as the impact of these micronutrients on microbiome composition and functionality. Personalized microbiome‐based intervention strategies could therefore constitute an innovative tool to counteract micronutrient deficiencies by modulating the gut microbiome toward an eubiotic configuration capable of satisfying the needs of our organism, while promoting general health.
Determinant factors and business strategy in a sustainable business model: An explorative analysis for the promotion of solid waste recycling technologies
Authors: Cui Yue , Cao Yunmeng , Ji Yijun , Chang I‐Shin , Wu Jing 
Published: March 2022

AbstractInnovation strategies for the promotion of solid waste recycling technologies include not only new technologies for resource utilization of solid waste but also sustainable business models to support the adoption of these technologies. This study presents how to incorporate the determinant factors affecting technology promotion and business strategy into a sustainable business model for the promotion of solid waste recycling technologies. A systematic literature review summarizes the determinant factors affecting the aforementioned promotion, including market‐, policy‐, company‐, and technology‐related factors. Combined with the theoretical background of the sustainable business model, this study analyzes that for the promotion of solid waste recycling technologies from value dimensions (value proposition, value creation & delivery, and value capture) and sustainability dimensions (economic, social, and environmental). We confirm the importance of incorporating determinant factors into the sustainable business model from the analysis of the Daye Non‐Ferrous Metal Recycling Park. Our case study proposes that innovation of the sustainable business model needs to drive changes in business strategy. To promote the aforementioned technologies, we propose an Internet‐based technology service platform as the core strategy of the sustainable business model. As the private sector, technology companies can make full use of technological innovation, public policies, and the market environment to achieve and develop sustained competitive advantages through an Internet‐based platform and to effectively enhance the promotion of solid waste recycling technologies and help achieve sustainable development.
Hysteresis in electrochemical systems
Authors: Van der Ven Anton , See Kimberly A. , Pilon Laurent 
Published: March 2022

AbstractHysteresis is a phenomenon that pervades both the physical and social sciences. While commonly associated with magnetism, it also occurs in a wide variety of other materials, including ferroelectrics and shape memory alloys. Hysteresis emerges when a particular property has a history dependence. It is exploited in microelectronic memory, logic, and neuromorphic devices. In electrochemical systems, such as Li‐ion batteries, hysteresis is undesirable as it leads to energy losses during each round trip charge–discharge cycle. Unfortunately, many new battery concepts that promise significant increases in energy density, including those that rely on displacement and conversion reactions, or on anion‐redox mechanisms, suffer from severe hysteresis that prevents their commercialization. This article surveys different forms of hysteresis in electrochemical systems with a focus on Li‐ion batteries and establishes thermodynamic and kinetic principles with which to understand and rationalize electrochemical hysteresis. The ability to control hysteresis in rechargeable batteries will enable the implementation of promising electrode chemistries. It will also open the door to many new device applications. As on‐chip batteries become more prominent, new possibilities will emerge to incorporate them not only as local energy sources but also as active components of new device concepts that exploit electrochemical hysteresis.
How does addiction of fast‐food turn into anti‐consumption of fast‐food? The mediating role of health concerns
Authors: Shahzad Muhammad Faisal , Lee Michael S. W. , Hasni Muhammad Junaid Shahid , Rashid Yasir 
Published: March 2022

AbstractThis research investigates the complex relationships between fast‐food addiction (FFA) and fast food‐anti‐consumption (FFAC). Specifically, we propose an intervening process through which FFA turns into FFAC. Using a randomised sample of 437 respondents from Sichuan Province, China, this study tests how concern about obesity and chronic disease arising from FFA can lead to FFAC. Consistent with published research, we find that consumers' situations (availability of fast‐foods, attitudes towards food) coupled with food‐based advertising practices are positively associated with FFA. Health concerns and food waste (FW) enhance negative feelings and motivate consumers to find ways to overcome FFA. As a result, consumers exhibit FFAC to overcome health concerns and undesirable mental states positively correlated with FFA. Our research offers new insights into the processes that drive FFAC and provides a robust guide for policymakers, applied psychologists, consumers, and food marketers who can use health‐related marketing appeals to limit the binge eating of unhealthy foods.
Minimum criteria for defining induced mesenchymal stem cells
Authors: Choudhery Mahmood S. , Mahmood Ruhma , Harris David T. , Ahmad Fridoon J. 
Published: March 2022

AbstractMesenchymal stem cells (MSCs) are a promising cell type for cell‐based therapies. The therapeutic potential of MSCs has been verified in preclinical and clinical studies, however; low cell number in adult tissues, restricted expansion and differentiation capacity, and donor‐related heterogeneity limit their use. To address these issues, there has been considerable interest in induced pluripotent stem cells (iPSCs) derived MSCs (induced mesenchymal stem cells [iMSCs]). Investigators obtain iMSCs from iPSCs of different origins, with variable methods of generation and expansion. Results of current studies have suggested iMSCs as a unique alternative source of MSCs. However, iMSCs are defined using the same criteria (proposed previously for primary MSCs by the International Society for Cellular Therapy [ISCT]) without realizing the distinct nature of iMSCs as compared to primary MSCs. To rationally define iMSCs, additional characterization is proposed along with ISCT's minimum criteria for defining primary MSCs. Minimum criteria for defining iMSCs should include (1) spindle‐shaped morphology, (2) plastic adherent growth, (3) positive expression of CD29, CD44, CD73, CD90, CD105, along with negative expression of hematopoietic markers (CD45, CD34, CD14 or CD11b, CD79α or CD19, HLA‐DR), (4) lack of expression of iPSCs induction factors, (5) trilineage differentiation potential, (6) lack of ability to form teratoma, and (7) release of MSC relevant paracrine factors. Defining the minimum criteria for iMSCs will be of great interest in the field and will provide a uniform description and identification of iMSCs to expedite progress in the field. Furthermore, due to increased interest in the clinical use of iMSCs, the above‐mentioned additional characterization before the clinical application is important to avoid unwanted complications for recipients.
OSI‐027 inhibits the tumorigenesis of colon cancer through mediation of c‐Myc/FOXO3a/PUMA axis
Authors: Lou Jie , Lv Jian‐Xin , Zhang You‐Ping , Liu Zhan‐Ju 
Published: March 2022

AbstractColon cancer is a gastrointestinal malignancy that is one of the leading causes of tumor‐associated deaths. It has been reported that the mammalian target of rapamycin (mTOR) can lead to the progression of colon cancer. However, the mechanism by which mTOR inhibitor (OSI‐027) mediates the tumorigenesis of colon cancer remains largely unknown. Cell function of colon cancer was investigated by cell counting kit‐8 flow cytometry and terminal deoxynucleotidyl transferase dUTP nick end labeling staining. In addition, quantitative real‐time polymerase chain reaction and Western blot were used to investigate the mechanism underlying the function of OSI‐027 in colon cancer. OSI‐027 dose‐dependently reduced colon cancer cell viability by inducing cell apoptosis. In addition, OSI‐027 induced the apoptosis of colon cancer cells via upregulation of PUMA. OSI‐027 promoted the expression of PUMA by activation of forkhead box protein O3a (FOXO3a), and c‐Myc knockdown partially increased FOXO3a and PUMA levels. Moreover, OSI‐027 attenuated the tumor growth of colon cancer through the mediation of the mTOR/c‐Myc/FOXO3a axis. OSI‐027 attenuates colon cancer progression through the mediation of the c‐Myc/FOXO3a/PUMA axis. Thereby, this study might shed new insights on exploring the strategies against colon cancer.