bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elimination of Foxo triplets following glucocorticoid incubation dampened metabolic stress and enhanced anti-viral response targets based on transcriptomic analysis
Authors: Puthanveetil Prasanth , Rafferty Daniel , Gan Boyi , Bolch Charlotte A. 
Published: November 2022

AbstractGlucocorticoids, both endogenous and exogenous, are known anti-inflammatory agents with associated adverse effects when administered chronically or in excess. Foxo family members, specifically Foxo1, Foxo3 and Foxo4 have demonstrated to be major regulators of metabolic complications following glucocorticoid action. We employed mouse embryonic fibroblasts as model system and using tamoxifen induced Cre+ recombinase activation, we achieved deletion of the Foxo triplets- Foxo1, Foxo3, and Foxo4. Following incubation of dexamethasone in both wild type and Foxo triplet deleted group, RNA sequencing was performed to reveal the transcriptome. Interestingly, the transcripts involved in initiating metabolic stress like PDK4 and 11 Beta HSD1 were downregulated, whereas transcripts involved in anti-viral response were upregulated following Foxo triplet deletion. The anti-inflammatory property of glucocorticoids was kept intact based on transcripts evaluated including GILZ and COX2. In summary, our study reveals a unique phenomenon where we will be able to manipulate glucocorticoid action by deleting Foxo triplets eliminating the metabolic stress components but enhancing anti-viral response and maintaining their clinical use as an anti-inflammatory agent. This work will lay foundation for a paradigm shift in clinical use of glucocorticoids according to therapeutic advantage with lesser adverse effects
Heart Rate Assessment in a Pediatric ICU with Non-Contact Infrared Thermography and Machine Learning
Authors: Kaur Amandeep , Prajapati Samyak , Singh Pradeep , Nagori Aditya , Lodha Rakesh , Sethi Tavpritesh 
Published: November 2022

AbstractHeart rate is one of the vital signs for monitoring health. Non-invasive, non-contact assessment of heart rate can lead to safe and potentially telemedicine based monitoring. Thermal videos as a modality for capturing heart rate has been underexplored. Regions with large vessels such as the face can capture the pulsatile change in temperature associated with the blood flow. The use of a machine learning-based approach to capture heart rate from continuous thermal videos is currently lacking. Our present clinical investigation comprises the continuous monitoring of heart rate from a smaller number of samples by using a combination of an efficient deep-learning-based segmentation followed by domain-knowledge-based feature calculation for estimating heart rate from 124 thermal imaging videos comprising 3,628,087 frames of 65 patients, admitted to the pediatric intensive care unit at AIIMS, New Delhi. We hypothesized that periodic fluctuations of thermal intensity over the face can capture heart rate. Frequency domain features for thermal time series were extracted followed by supervised learning using a battery of models. A random forest model yielded the best results with a root mean squared error of 24.54 and mean absolute percentage error of 16.129. Clinical profiling of the model showed a wide range of clinical conditions in the admitted children with acceptable model performance. Affordable and commercially available thermal cameras establish the feasibility and cost viability of exploring deployments for patient heart rate estimation in non-invasive and non-contact environments.
Sex-specific neurodevelopmental outcomes in offspring of mothers with SARS-CoV-2 in pregnancy: an electronic health records cohort
Authors: Edlow Andrea G. , Castro Victor M. , Shook Lydia L. , Haneuse Sebastien , Kaimal Anjali J. , Perlis Roy H. 
Published: November 2022

AbstractImportancePrior studies using large registries suggested a modest increase in risk for neurodevelopmental diagnoses among children of mothers with immune activation during pregnancy, and such risk may be sex-specific.ObjectiveTo determine whether in utero exposure to the novel coronavirus SARS-CoV-2 is associated with sex-specific risk for neurodevelopmental disorders up to 18 months after birth, compared to unexposed offspring born during or prior to the pandemic period.DesignRetrospective cohort.ParticipantsLive offspring of all mothers who delivered between March 2018 and May 2021 at any of eight hospitals across two health systems in Massachusetts.ExposurePCR evidence of maternal SARS-CoV-2 infection during pregnancy.Main Outcome and MeasuresElectronic health record documentation of ICD-10 diagnostic codes corresponding to neurodevelopmental disorders.ResultsThe pandemic cohort included 18,323 live births, including 877 (4.8%) to individuals with SARS-CoV-2 positivity during pregnancy. The cohort included 1806 (9.9%) Asian individuals, 1634 (8.9%) Black individuals, 1711 (9.3%) individuals of another race, and 12,694 (69%) White individuals; 2614 (14%) were of Hispanic ethnicity. Mean maternal age was 33.0 years (IQR 30.0-36.0). In adjusted regression models accounting for race, ethnicity, insurance status, hospital type (academic center vs. community), maternal age, and preterm status, SARS-CoV-2 positivity was associated with statistically significant elevation in risk for neurodevelopmental diagnoses among male offspring (adjusted OR 1.99, 95% CI 1.19-3.34; p=0.009) but not female offspring (adjusted OR 0.90, 95% CI 0.43-1.88; p=0.8). Similar effects were identified using matched analyses in lieu of regression.Conclusion and RelevanceSARS-CoV-2 exposure in utero was associated with greater magnitude of risk for neurodevelopmental diagnoses among male offspring in the 12 months following birth. As with prior studies of maternal infection, substantially larger cohorts and longer follow-up will be required to reliably estimate or refute risk.Trial RegistrationNAKey PointsQuestionAre rates of neurodevelopmental disorder diagnoses greater among male or female children with COVID-19 exposure in utero compared to those with no such exposure?FindingsIn a cohort of 18,323 infants delivered after February 2020, males but not females born to mothers with a positive SARS-CoV-2 PCR test during pregnancy were more likely to receive a neurodevelopmental diagnosis in the first 12 months after delivery, even after accounting for preterm delivery.MeaningThese findings suggest that male offspring exposed to COVID-19 in utero may be at increased risk for neurodevelopmental disorders.
Socioeconomic inequalities in sport participation: pattern per sport and time trends
Authors: Richard Viviane , Piumatti Giovanni , Pullen Nick , Lorthe Elsa , Guessous Idris , Cantoreggi Nicola , Stringhini Silvia 
Published: November 2022

ABSTRACTBackgroundSport participation is an important component of a healthy lifestyle and is known to be more common among privileged individuals. However, few studies have examined socio-demographic patterns of participation by type of activity. This study aims at quantifying socio-economic inequalities in sport participation by sport type, and to analyse their trend over 15 years.MethodsWe used 2005-2019 data from the Bus Santé study, a yearly population-based cross-sectional survey of Geneva adults. Sport participation was defined as reporting at least one sporting activity over the previous week; educational level, household income and occupational position were used as indicators of socio-economic position. Socio-economic inequalities in sport participation, and their trend over time, were examined using the relative and slope indexes of inequality (RII/SII).ResultsOut of 7769 participants (50.1% women, mean age 46 years old), 60% participated in a sporting activity. Results showed that the higher the socioeconomic circumstances, the higher the sport participation (RII=1.78; 95% Confidence Interval (CI): 1.64-1.92; SII=0.33; 95%CI: 0.29-0.37 for education). Relative inequalities varied per sport e.g., 0.68 (95%CI: 0.44-1.07) in football participation and 4.25 (95%CI: 2.68-6.75) in tennis/badminton participation for education. Yearly absolute inequalities in sport participation tended to increase between 2005 and 2019 for household income (β=0.01; P-value=0.024).ConclusionWe observed strong socio-economic inequalities in sport participation in Geneva, with different magnitude depending on the type of sport. These inequalities seemed to increase over the 2005-2019 period. Our results call for tailored measures to promote the participation of socially disadvantaged populations in sporting activities.KEY MESSAGESSport participation is associated with higher socioeconomic conditions. Research on the patterning of inequalities per sport type and on their trend over time remains scarce.There are high growing socioeconomic inequalities in sport participation in Geneva. Inequalities in sport participation are heterogeneous and lower in sports practised in group.Tailored sport promotion measures are needed for disadvantaged populations.
Mindfulness supports emotional resilience in children during the COVID-19 Pandemic
Authors: Treves Isaac N. , Li Cindy E. , Wang Kimberly L. , Ozernov-Palchik Ola , Olson Halie A. , Gabrieli John D.E. 
Published: November 2022

AbstractAn important aspect of mental health in children is emotional resilience, the capacity to adapt to, and recover from, stressors and emotional challenges. Variation in trait mindfulness, one’s disposition to attend to experiences with an open and nonjudgmental attitude, may be an important individual difference in children that supports emotional resilience. In this study, we investigated whether trait mindfulness was related to emotional resilience in response to stressful changes in education and home-life during the COVID-19 pandemic in the United States. We conducted a correlational study examining self-report data from July 2020 to February 2021, from 163 eight-to-ten-year-old children living in the US. Higher trait mindfulness scores correlated with less stress, anxiety, depression, and negative affect in children, and lower ratings of COVID-19 impact on their lives. Mindfulness moderated the relationship between COVID-19 child impact and negative affect. Children scoring high on mindfulness showed no correlation between rated COVID-19 impact and negative affect, whereas those who scored low on mindfulness showed a positive correlation between child COVID-19 impact and negative affect. Higher levels of trait mindfulness may have helped children to better cope with a wide range of COVID-19 stressors. Future studies should investigate the mechanisms by which trait mindfulness supports emotional resilience in children.
Dementia diagnosis and prevalence in the Lothian Birth Cohort 1936 using medical data linkage
Authors: Mullin Donncha S. , Stirland Lucy E. , Buchanan Emily , Convery Catherine-Anne , Cox Simon R. , Deary Ian J. , Giuntoli Cinzia , Greer Holly , Page Danielle , Robertson Elizabeth , Shenkin Susan D. , Szalek Anna , Taylor Adele , Weatherdon Georgina , Wilkinson Tim , Russ Tom C. 
Published: November 2022

AbstractBackgroundThe Lothian Birth Cohort 1936 (LBC1936) is a longitudinal study of ageing with well-characterised assessments, but until now, it has relied on self-report or proxies for dementia outcomes. This report describes a framework for clinical dementia ascertainment and its implementation. We report the prevalence of all-cause dementia and dementia subtypes in 865 individuals aged 70 years and older from the LBC1936.MethodsElectronic Health Records (EHR) of all participants were reviewed, and relevant information was extracted to form case vignettes for everyone with any record of cognitive dysfunction. The EHR data sources include hospital and clinic letters, general practitioner and hospital referrals, prescribed medications, imaging and laboratory results. Death certificate data were obtained separately. Clinician assessments were performed when there was concern about a participant’s cognition. A diagnosis of probable dementia, possible dementia, or no dementia was agreed upon by a consensus diagnostic review board, comprised of a multidisciplinary team of clinical dementia experts who reviewed case vignettes and clinician assessment letters. For those with probable dementia, a subtype was also determined, where possible. Finally, we compared the agreement between our newly ascertained dementia outcomes with the existing self-reported dementia outcomes.ResultsThe EHR review identified 163 out of 865 (18.8%) individuals as having cognitive dysfunction. At the consensus diagnostic review board, 118/163 were diagnosed with probable all-cause dementia, a prevalence of 13.6%. Age-specific dementia prevalence increased with age from 0.8% (65-74.9 years) to 9.93% (85-89.9 years). Prevalence rates for women were higher in nearly all age groups. The most common subtype was dementia due to Alzheimer disease (49.2%), followed by mixed Alzheimer and cerebrovascular disease (17.0%), dementia of unknown or unspecified cause (16.1%), and dementia due to vascular disease (8.5%). Self-reported dementia outcomes were positive in only 17.8% of ascertained dementia outcomes.ConclusionsDementia outcomes have been clinically ascertained in the LBC1936 using a robust systematic approach that closely aligns with diagnosing dementia in practice. This provides useful detailed outcomes for further analyses of LBC1936 to allow exploration of lifecourse predictors of dementia.
Seizing the moment in the flux of Industry 4.0: technological opportunism, innovativeness and new product performance in international markets
Authors: Cho Jinwan , Jeong Insik , Kim Eunmi , Cho Hyo Eun 
Published: November 2022

PurposeRecent technological turbulence stemming from Industry 4.0 provides managerial opportunities and challenges simultaneously. In this context, the purpose of this study is to explore the role of technological opportunism on innovativeness and discover the impact of innovativeness on new products performance in international markets.Design/methodology/approachTo empirically test the hypotheses, the authors have collected survey data from 237 Korean exporting firms and applied structural equation modeling.FindingsEmpirical results indicate that technological opportunism, which represents technology sensing and responding capability, has a positive and significant influence on both exploratory and exploitative innovativeness. Also, explorative and exploitative innovativeness have positive and significant effects on new product performance in international markets.Practical implicationsThis study highlighted the importance of technology sensing and responding capabilities to capture emerging opportunities, which may arise from Industry 4.0 technologies. In addition, sensing and responding capabilities will help a firm create a culture that values innovative proclivity, and in turn, will lead to superior new product performance in international markets.Originality/valueDespite extensive scholarly interest in Industry 4.0, previous studies have neglected to address the potential impact of Industry 4.0 within the domain of new product development and its performance. Also, there have been several calls from the literature to address the managerial and strategic issues surrounding the Industry 4.0 phenomenon. In this study, the authors attempted to fill the research gaps in Industry 4.0 research studies through empirical examination.
Assessing brand performance consistency from consumer-generated media: the US hotel industry
Authors: Jeong Miyoung , Shin Hyejo Hailey , Lee Minwoo , Lee Jongseo 
Published: November 2022

Purpose
Given the importance of performance consistency of chain hotels in customers’ decision-making and service evaluation, this study aims to explore how consistently chain hotel brands offer quality service and carry out their performance from the eyes of customers through online reviews on TripAdvisor of the top five US hotel chains (i.e. Choice, Hilton, InterContinental, Marriott and Wyndham) and their brands.

Design/methodology/approach
The research objectives were achieved through methodological triangulation: business intelligence, data visualization analytics and statistical analyses. First, the data collection and pre-processing of consumer-generated media (CGM) (i.e. TripAdvisor online reviews) were performed using business intelligence for further analyses. Using data visualization analytics (i.e. box-and-whisker plot by region and brand), the geographic patterns of performance attributes (i.e. online review ratings, including location, sleep, cleanliness, room and service) were depicted. Using a series of analyses of variance and regression analyses, the results were further assessed for the impacts of brand performance inconsistency on consumers’ perceived value, sentiment and satisfaction.

Findings
The empirical results demonstrate that there are significant performance inconsistencies in performance attributes (location, sleep, cleanliness, room and service) by brands throughout the six regions in the US hotel market. More importantly, the findings confirm that brand performance consistency significantly influences consumers’ perceived service quality (i.e. perceived value, satisfaction and sentiment).

Originality
This study is one of the first attempts to empirically explore hotel brand performance consistency in the US hotel market from customer reviews on CGM. To measure hotel brand performance in the US hotel market, this study collected and analyzed user-generated big data for the top 5 US hotel chains through business intelligence, visualization analytics and statistical analysis. These integrated and novel research methods would help tourism and hospitality researchers analyze big data in an innovative data analytics approach. The findings of the study contribute to the tourism and hospitality field by confirming hotel brand performance inconsistency and such inconsistent performance affected customers’ service evaluations.

Practical Implications
This study demonstrates the significant impact of hotel brand performance consistency on consumers’ perceived value, emotion and satisfaction. Considering that online reviews are perceived as a credible source of information, the findings suggest that the hotel industry pays special attention to brand performance consistency to improve consumers’ perceived value, emotion and satisfaction.
The effect of telework on emotional exhaustion and task performance via work overload: the moderating role of self-leadership
Authors: Junça Silva Ana , Almeida Alexandra , Rebelo Carla 
Published: November 2022

PurposeThis study aims to develop a framework that explains how and when telework is related to emotional exhaustion and task performance, by conceiving work overload as a mediator and self-leadership as a moderator. For this purpose, two studies were conducted. Study 1 aims to understand whether telework would be related to emotional exhaustion and task performance and if work overload would mediate such relationships. Study 2 aims to analyze whether self-leadership was a significant moderator of the mediated relations found in Study 1.Design/methodology/approachThe hypotheses were tested in a sample of 207 (in Study 1) and 272 (in Study 2) participants, which were exclusively teleworking. The results were analyzed using PROCESS macro in SPSS.FindingsThe results of Study 1 showed that telework dimensions were negatively related to work overload, which consequently decreased emotional exhaustion and increased task performance. In Study 2, self-leadership moderated the indirect effect of work overload on the relationship between telework and emotional exhaustion, such that the indirect effect was stronger for those who scored higher in self-leadership. However, it was not significant for task performance.Originality/valueThis paper adds to research on telework by focusing on the employee's mental health and performance, in the context of mandatory confinement. The authors identified telework dimensions that may act as resources to cope with the increased work overload inherent to telework, as well as the importance of personal resources in these relationships.
Chosen, trusted and disillusioned – an autoethnographic account of university–society collaboration from an academic's point
Authors: Nylén Ulrica 
Published: November 2022

PurposeThe purpose of this paper is to understand the dynamic and power-laden nature of university–society collaboration from the individual academic's point of view.Design/methodology/approachThis paper applies an autoethnographic approach in following a specific collaboration process through detailed fieldnotes and continuous reflections.FindingsThis research presents university–society collaboration as an emergent, volatile and fairly unpredictable process, involving a multitude of actors on both sides. The interactions among actors shape the emerging process and power relationships. The academic's situation could be understood in terms of multiple and shifting subject positions that could be embraced, accepted, resisted or surrendered to by the academic.Practical implicationsThese findings may help academics with own experiences of collaboration to shed light on their observations. Novice academics, interested in collaborating with society, should be aware of the possibility of tensions and exercise of power in interactions with societal actors. When setting up collaboration agreements, academic and societal actors are advised to openly discuss potential problems and how to handle those.Originality/valueThis unique, in-depth testimony of a single collaboration process from the individual academic's point of view uncovers previously unobserved dynamic and political attributes of the process.