bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of an automated interview grounded in multiple mini interview (MMI) methodology for selection into the health professions: an international multimethod evaluation
Authors: Callwood Alison , Gillam Lee , Christidis Angelos , Doulton Jia , Harris Jenny , Piano Marianne , Kubacki Angela , Tiffin Paul A , Roberts Karen , Tarmey Drew , Dalton Doris , Valentin Virginia L 
Published: February 2022

ObjectivesGlobal, COVID-driven restrictions around face-to-face interviews for healthcare student selection have forced admission staff to rapidly adopt adapted online systems before supporting evidence is available. We have developed, what we believe is, the first automated interview grounded in multiple mini-interview (MMI) methodology. This study aimed to explore test–retest reliability, acceptability and usability of the system.Design, setting and participantsMultimethod feasibility study in Physician Associate programmes from two UK and one US university during 2019–2020.Primary, secondary outcomesFeasibility measures (test–retest reliability, acceptability and usability) were assessed using intraclass correlation (ICC), descriptive statistics, thematic and content analysis.MethodsVolunteers took (T1), then repeated (T2), the automated MMI, with a 7-day interval (±2) then completed an evaluation questionnaire. Admission staff participated in focus group discussions.ResultsSixty-two students and seven admission staff participated; 34 students and 4 staff from UK and 28 students and 3 staff from US universities. Good-excellent test–retest reliability was observed at two sites (US and UK2) with T1 and T2 ICC between 0.65 and 0.81 (p<0.001) when assessed by individual total scores (range 80.6–119), station total scores 0.6–0.91, p<0.005 and individual site (≥0.79 p<0.001). Mean test re-test ICC across all three sites was 0.82 p<0.001 (95% CI 0.7 to 0.9). Admission staff reported potential to reduce resource costs and bias through a more objective screening tool for preselection or to replace some MMI stations in a ‘hybrid model’. Maintaining human interaction through ‘touch points’ was considered essential. Users positively evaluated the system, stating it was intuitive with an accessible interface. Concepts chosen for dynamic probing needed to be appropriately tailored.ConclusionThese preliminary findings suggest that the system is reliable, generating consistent scores for candidates and is acceptable to end users provided human touchpoints are maintained. Thus, there is evidence for the potential of such an automated system to augment healthcare student selection.
‘You’re just there, alone in your room with your thoughts’: a qualitative study about the psychosocial impact of the COVID-19 pandemic among young people living in the UK
Authors: McKinlay Alison R , May Tom , Dawes Jo , Fancourt Daisy , Burton Alexandra 
Published: February 2022

ObjectivesAdolescents and young adults have been greatly affected by quarantine measures during the COVID-19 pandemic, but little is understood about how restrictions have affected their well-being, mental health, and social life. We therefore aimed to learn more about how UK quarantine measures affected the social lives, mental health and well-being of adolescents and young adults.DesignQualitative interview study. The data were analysed using reflexive thematic analysis, with particular attention paid to contextual factors (such as age, gender, ethnicity and health status) when analysing each individual transcript.SettingData collection took place remotely across the UK via audio or video call, between June 2020 and January 2021.ParticipantsWe conducted semi-structured interviews with 37 participants (aged 13–24 years) to elicit their views.ResultsAuthors generated four themes during the qualitative analysis: (a) concerns about disruption to education, (b) missing social contact during lockdown, (c) changes to social relationships and (d) improved well-being during lockdown. Many participants said they struggled with a decline in mental health during the pandemic, lack of support and concern about socialising after the pandemic. However, some participants described experiences and changes brought on by the pandemic as helpful, including an increased awareness of mental health and feeling more at ease when talking about it, as well as stronger relationship ties with family members.ConclusionsFindings suggest that young people may have felt more comfortable when talking about their mental health compared with prepandemic, in part facilitated by initiatives through schools, universities and employers. However, many were worried about how the pandemic has affected their education and social connections, and support for young people should be tailored accordingly around some of these concerns.
Individual and contextual predictors of emergency department visits among community-living older adults: a register-based prospective cohort study
Authors: Naseer Mahwish , J McKee Kevin , Ehrenberg Anna , Schön Pär , Dahlberg Lena 
Published: February 2022

ObjectivesTo examine the extent to which contextual factors explain emergency department (ED) visits and ED revisits, additional to that explained by individual factors.DesignA register-based prospective cohort study.SettingSwedish region of Dalarna.ParticipantsParticipants were 16 543 community-living adults aged 80 or older who were residents of the Dalarna region of Sweden, excluding older adults who moved out of Dalarna or into residential care during the study period.Outcome measuresDependent variables were initial ED visit, and at least one ED revisit within 30 days of an initial ED visit.ResultsApproximately 36% of the participants visited the ED during the study period with 18.9% returning to the ED within 30 days. For both initial ED visits and ED revisits, the addition of contextual factors to models containing individual factors significantly improved model fit (p<0.001; p<0.022) and the amount of variance explained in the outcome. In the final models, initial ED visit was significantly associated with older age, number of chronic diseases, receipt of home help, number of primary care visits, proportion of 80+ in the population and shorter distance to the ED; while an ED revisit was significantly associated with greater use of social care, number of hospital admissions and disposition (discharged; admitted to hospital) at initial ED visit.ConclusionContextual factors explain variance in initial ED visit, additional to that explained by individual factors alone, which indicates inequitable access to ED care. These findings suggest considering local variations in contextual factors in order to improve health-related outcomes among older adults.
Changes in mental health problems and suicidal behaviour in students and their associations with COVID-19-related restrictions in Norway: a national repeated cross-sectional analysis
Authors: Sivertsen Børge , Knapstad Marit , Petrie Keith , O’Connor Rory , Lønning Kari Jussie , Hysing Mari 
Published: February 2022

ObjectiveThe COVID-19 pandemic has had a devastating impact on higher education, with the closure of student campuses. The aim of this study was to examine changes and prevalence of mental health problems, suicidal ideation and suicidal behaviour, and their associations with COVID-19-related restrictions.Design, setting and participantsAs part of the SHoT-study in Norway, 62 498 students completed an online questionnaire (65.6% women; response rate of 34.4%) in March 2021. Data were compared with previous waves, conducted in 2018, 2014 and 2010.Primary and secondary outcome measuresMental health problems were assessed using the Hopkins Symptoms Checklist. Suicidal ideation, suicide attempts and non-suicidal self-harm (NSSH) were assessed with three items drawn from the Adult Psychiatric Morbidity Survey, and thoughts of NSSH were assessed with one item from the Child and Adolescent Self-Harm in Europe study.ResultsThere was a significant increase in mental health problems from 2010 to 2021, and especially from 2018 (men: 27%/women: 45%) to 2021 (men: 41%/women: 62%, p <0.001). A similar pattern was also observed for suicidal thoughts. Unlike previous waves, there were large geographical differences in mental health problems in 2021, which mapped onto the different levels of COVID-19 cases and regional COVID-19-related restrictions. There was a significant negative dose–response association between days spent physically on campus and both mental health problems and indicators of suicide risk. We found the fewer days spent on campus in the last 2 weeks, the higher levels of mental health problems during the same time period. There was also an association between days on campus and a higher prevalence of suicidal thoughts, NSSH and suicide attempts in the last year.ConclusionThis study demonstrates a sharp increase and disturbing levels of mental health problems and suicide risk among students during the COVID-19 pandemic. Although causal conclusions cannot be drawn, the associations between closure of campuses and mental problems emphasise the importance of having access to campuses for student well-being.
Are professors of human nutrition faculty at Canadian universities representative with respect to common social constructs of gender and race?
Authors: McBurney Michael I. 
Published: February 2022

Attributes such as sex and race/ethnicity are associated with inequities in representation. The objective of this study was to assess representation of 2 social constructs, gender and race, of professors of human nutrition in Canada. Using information publicly available October 2021, individuals with the title of assistant, associate, or full professor were identified on websites of 20 Canadian universities offering undergraduate and/or graduate degrees in human nutrition. Individuals were subjectively stratified to social constructs, i.e., white, racialized, or Indigenous, based on photographs, ethnic origin of a surname, and regional and ethnic origin disclosures on university websites, LinkedIn, social media, etc. Gender was assigned based on publicly available photographs and self-disclosed pronouns (when available). Of the 190 individuals, 80% were white, 16.4% were racialized, and 2.6% were Indigenous peoples. The majority (65.3%) were women. In a subset with established doctoral thesis dates and dates of hire at their current institution (n = 153), racialized and Indigenous professors, especially assistant and associate, had earned their doctorate and been hired more recently than their white peers. This study is limited because only individuals with professorial titles were included and the assignment of social constructs for race and gender was subjective. Nevertheless, it establishes an understanding of the proportions of professors of human nutrition who are white, racialized, Indigenous, women, and men. Novelty: Canadian universities strive to be equitable, diverse, and inclusive. One hundred and ninety professors of human nutrition were stratified using social constructs for race and gender. Findings: 65% Women, 80% white, 16.4% racialized, and 2.6% Indigenous
Collagenase and the Treatment of Dupuytren Contracture: Efficacy of Treatment and Patient Satisfaction
Authors: CLESHAM Kevin , SHERIDAN Gerard A. , MURPHY Evelyn P. , O’ CONNOR Sharon P. , O’ SULLIVAN Michael E. 
Published: February 2022

Background: Collagenase clostridium histolyticum has become a widely used treatment in the management of Dupuytren disease. The aims of this study are to assess the immediate success of treatment of Dupuytren contracture with collagenase injection, to measure long-term patient-rated outcomes, to determine whether the risk factors for the disease impacted outcomes and to report complications of collagenase treatment. Methods: A prospective study was performed in a tertiary referral centre. Measurements were recorded pre-treatment, day 1 and day 90. Patient-rated outcome scores were measured using Disability of the Arm, Shoulder and Hand questionnaire (DASH) and the Michigan Hand Questionnaire (MHQ) at minimum 36 months post-injection. Results: The study included 45 patients with 53 hands with a mean age of 65.7 years. The treatment was successful in 62% of patients with the greatest improvement in the metacarpal-phalangeal joint of the little finger. Diabetes, epilepsy, gender, alcohol intake and positive family history had no statistically significant predictive value on successful outcomes. Patient satisfaction at 41 months was high with mean MHQ score of 97.3. Conclusions: Collagenase is effective in the treatment of Dupuytren contracture, with disease involving the little finger showing the greatest benefit. Risk factors for development of Dupuytren disease had no effect on successful outcome and long-term satisfaction rates are high. Level of Evidence: Level III (Therapeutic)
Shifting Beliefs in Computer Science: Change in CS Student Mindsets
Authors: Flanigan Abraham E. , Peteranetz Markeya S. , Shell Duane F. , Soh Leen-Kiat 
Published: February 2022

Two studies investigated change in computer science (CS) students’ implicit intelligence beliefs. Across both studies, we found that the strength of incremental and entity beliefs changed across time. In Study 1, we found that incremental beliefs decreased and entity beliefs increased across the semester. Change in implicit intelligence beliefs was similar for students taking introductory and upper-division courses. In Study 2, growth curve analysis revealed a small linear change in incremental beliefs across time but no change in entity beliefs—these trends were similar for students enrolled in introductory and upper-division CS courses. Across both studies, change in implicit intelligence beliefs was not associated with academic achievement in CS. Findings provide preliminary evidence that shifts in implicit intelligence beliefs occur as students progress through the CS curriculum. Finally, findings support that mindset interventions may be more effective if delivered at the beginning of the semester before shifts in beliefs occur.
Accelerating Weather Prediction Using Near-Memory Reconfigurable Fabric
Authors: Singh Gagandeep , Diamantopoulos Dionysios , Gómez-Luna Juan , Hagleitner Christoph , Stuijk Sander , Corporaal Henk , Mutlu Onur 
Published: February 2022

Ongoing climate change calls for fast and accurate weather and climate modeling. However, when solving large-scale weather prediction simulations, state-of-the-art CPU and GPU implementations suffer from limited performance and high energy consumption. These implementations are dominated by complex irregular memory access patterns and low arithmetic intensity that pose fundamental challenges to acceleration. To overcome these challenges, we propose and evaluate the use of near-memory acceleration using a reconfigurable fabric with high-bandwidth memory (HBM). We focus on compound stencils that are fundamental kernels in weather prediction models. By using high-level synthesis techniques, we develop NERO, an field-programmable gate array+HBM-based accelerator connected through Open Coherent Accelerator Processor Interface to an IBM POWER9 host system. Our experimental results show that NERO outperforms a 16-core POWER9 system by

\( 5.3\times \)

and

\( 12.7\times \)

when running two different compound stencil kernels. NERO reduces the energy consumption by

\( 12\times \)

and

\( 35\times \)

for the same two kernels over the POWER9 system with an energy efficiency of 1.61 GFLOPS/W and 21.01 GFLOPS/W. We conclude that employing near-memory acceleration solutions for weather prediction modeling is promising as a means to achieve both high performance and high energy efficiency.
Bias Reduction through Analysis of Competing Events (BRACE) Correction to Address Cancer Treatment Selection Bias in Observational Data
Authors: Williamson Casey W. , Nelson Tyler J. , Thompson Caroline A. , Vitzthum Lucas K. , Zakeri Kaveh , Riviere Paul J. , Bryant Alex K. , Sharabi Andrew B. , Zou Jingjing , Mell Loren K. 
Published: February 2022

Abstract

Purpose:
Cancer treatments can paradoxically appear to reduce the risk of noncancer mortality in observational studies, due to residual confounding. Here we introduce a method, Bias Reduction through Analysis of Competing Events (BRACE), to reduce bias in the presence of residual confounding.

Experimental Design:
BRACE is a novel method for adjusting for bias from residual confounding in proportional hazards models. Using standard simulation methods, we compared BRACE with Cox proportional hazards regression in the presence of an unmeasured confounder. We examined estimator distributions, bias, mean squared error (MSE), and coverage probability. We then estimated treatment effects of high versus low intensity treatments in 36,630 prostate cancer, 4,069 lung cancer, and 7,117 head/neck cancer patients, using the Veterans Affairs database. We analyzed treatment effects on cancer-specific mortality (CSM), noncancer mortality (NCM), and overall survival (OS), using conventional multivariable Cox and propensity score (adjusted using inverse probability weighting) models, versus BRACE-adjusted estimates.

Results:
In simulations with residual confounding, BRACE uniformly reduced both bias and MSE. In the absence of bias, BRACE introduced bias toward the null, albeit with lower MSE. BRACE markedly improved coverage probability, but with a tendency toward overcorrection for effective but nontoxic treatments. For each clinical cohort, more intensive treatments were associated with significantly reduced hazards for CSM, NCM, and OS. BRACE attenuated OS estimates, yielding results more consistent with findings from randomized trials and meta-analyses.

Conclusions:
BRACE reduces bias and MSE when residual confounding is present and represents a novel approach to improve treatment effect estimation in nonrandomized studies.
Psicologia concreta e humanismo: Foucault crítico de Politzer
Authors: Noto Carolina de Souza 
Published: February 2022

No presente artigo pretendo confrontar a crítica que Foucault faz à psicologia e a psicanálise em seus textos da década de 1950, com aquela que Georges Politzer desenvolve em seu famoso Crítica dos fundamentos da psicologia, de 1928. Trata-se de mostrar que apesar de alguns pontos de convergência, a crítica de Foucault é, desde o início, mais radical que a de Politzer e atinge a própria psicologia concreta proposta por este.
Autophagy Is Differentially Regulated in Leukocyte and Nonleukocyte Foam Cells During Atherosclerosis
Authors: Robichaud Sabrina , Rasheed Adil , Pietrangelo Antonietta , Doyoung Kim Anne , Boucher Dominique M. , Emerton Christina , Vijithakumar Viyashini , Gharibeh Lara , Fairman Garrett , Mak Esther , Nguyen My-Anh , Geoffrion Michele , Wirka Robert , Rayner Katey J. , Ouimet Mireille 
Published: February 2022

Rationale:
Atherosclerosis is characterized by an accumulation of foam cells within the arterial wall, resulting from excess cholesterol uptake and buildup of cytosolic lipid droplets (LDs). Autophagy promotes LD clearance by freeing stored cholesterol for efflux, a process that has been shown to be atheroprotective. While the role of autophagy in LD catabolism has been studied in macrophage-derived foam cells, this has remained unexplored in vascular smooth muscle cell (VSMC)-derived foam cells that constitute a large fraction of foam cells within atherosclerotic lesions.

Objective:
We performed a comparative analysis of autophagy flux in lipid-rich aortic intimal populations to determine whether VSMC-derived foam cells metabolize LDs similarly to their macrophage counterparts.

Methods and Results:
Atherosclerosis was induced in GFP-LC3 (microtubule-associated proteins 1A/1B light chain 3) transgenic mice by PCSK9 (proprotein convertase subtilisin/kexin type 9)-adeno-associated viral injection and Western diet feeding. Using flow cytometry of aortic digests, we observed a significant increase in dysfunctional autophagy of VSMC-derived foam cells during atherogenesis relative to macrophage-derived foam cells. Using cell culture models of lipid-loaded VSMCs and macrophages, we show that autophagy-mediated cholesterol efflux from VSMC foam cells was poor relative to macrophage foam cells, and largely occurs when HDL (high-density lipoprotein) was used as a cholesterol acceptor, as opposed to apoA-1 (apolipoproteinA-1). This was associated with the predominant expression of ABCG1 in VSMC foam cells. Using metformin, an autophagy activator, cholesterol efflux to HDL was significantly increased in VSMC, but not in macrophage, foam cells.

Conclusions:
These data demonstrate that VSMC and macrophage foam cells perform cholesterol efflux by distinct mechanisms, and that autophagy flux is highly impaired in VSMC foam cells, but can be induced by pharmacological means. Further investigation is warranted into targeting autophagy specifically in VSMC foam cells, the predominant foam cell subtype of advanced atherosclerotic plaques, to promote reverse cholesterol transport and resolution of the atherosclerotic plaque.
Reduced Severity of Tissue Injury Within the Infarct May Partially Mediate the Benefit of Reperfusion in Ischemic Stroke
Authors: Ng Felix C. , Churilov Leonid , Yassi Nawaf , Kleinig Timothy J. , Thijs Vincent , Wu Teddy Y. , Shah Darshan G. , Dewey Helen M. , Sharma Gagan , Desmond Patricia M. , Yan Bernard , Parsons Mark W. , Donnan Geoffrey A. , Davis Stephen M. , Mitchell Peter J. , Leigh Richard , Campbell Bruce C.V. ,   on behalf of the EXTEND-IA TNK Part 1 and 2 Investigators
Published: February 2022

Background:
Emerging data suggest tissue within the infarct lesion is not homogenously damaged following ischemic stroke but has a gradient of injury. Using blood-brain-barrier (BBB) disruption as a marker of tissue injury, we tested whether therapeutic reperfusion improves clinical outcome by reducing the severity of tissue injury within the infarct in patients with ischemic stroke.

Methods:
In a pooled analysis of patients treated for anterior circulation large vessel occlusion in the EXTEND-IA TNK (Tenecteplase Versus Alteplase Before Endovascular Therapy for Ischemic Stroke) and EXTEND-IA part-2 (Determining the Optimal Dose of Tenecteplase Before Endovascular Therapy for Ischaemic Stroke) trials, post-treatment BBB permeability at 24 hours was calculated based on the extent of T1-brightening by extravascular gadolinium on T2* perfusion-weighted imaging and measured within the diffusion-weighted-imaging lesion. First, to determine the clinical significance of BBB disruption as a marker of severity of tissue injury, we examined the association between post-treatment BBB permeability and functional outcome. Second, we performed an exploratory (reperfusion, BBB permeability, functional outcome) mediation analysis to estimate the proportion of the reperfusion-outcome relationship that is mediated by change in BBB permeability.

Results:

In the 238 patients analyzed, an increased BBB permeability measured within the infarct at 24 hours was associated with a reduced likelihood of favorable outcome (90-day modified Rankin Scale score of ≤2) after adjusting for age, baseline National Institutes of Health Stroke Scale, premorbid modified Rankin Scale, infarct topography, laterality, thrombolytic agent, sex, parenchymal hematoma, and follow-up infarct volume (adjusted odds ratio, 0.86 [95% CI, 0.75–0.98];
P
=0.023). Mediation analysis suggested reducing the severity of tissue injury (as estimated by BBB permeability) accounts for 18.2% of the association between reperfusion and favorable outcome, as indicated by a reduction in the regression coefficient of reperfusion after addition of BBB permeability as a covariate.

Conclusions:
In patients with ischemic stroke, reduced severity of tissue injury within the infarct, as determined by assessing the integrity of the BBB, is independently associated with improved functional outcome. In addition to reducing diffusion-weighted imaging-defined infarct volume, reperfusion may also improve clinical outcome by reducing tissue injury severity within the infarct.