bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive factors of academic success in neuromusculoskeletal anatomy among doctor of physical therapy students
Authors: Harmon Derek J. , Attardi Stefanie M. , Waite Jordan G. , Topp Kimberly S. , Smoot Betty J. , Farkas Gary J. 
Published: June 2022

AbstractPredictors of academic success in anatomy have been studied, but not in Doctor of Physical Therapy (DPT) students. The objectives of this study were to (1) explore predictors of academic success in a DPT anatomy course, (2) evaluate sex‐based differences in the predictors of academic success and their influence on anatomy course grade, and (3) investigate the influence of the DPT anatomy course on visual–spatial ability. Forty‐nine DPT students completed a demographic questionnaire, Learning and Study Strategies Inventory (LASSI), and Mental Rotations Test (MRT) before the ten‐week anatomy course (MRT‐1) and repeated the MRT at the end of the course (MRT‐2). Anatomy course grade was determined based on quizzes and written and practical examinations. Multiple regression analysis showed significant associations between the predictor variables age (p = 0.010) and the LASSI anxiety subscale (p = 0.017), which measures anxiety coping, with the anatomy course grade. On the MRT‐1, male DPT students attempted and correctly answered more questions than females (both, p < 0.0001). Female students had higher LASSI self‐regulation and use of academic resources subscale scores (both, p < 0.05). In the 44 DPT students that completed the MRT‐2, the number of correct and attempted responses increased following the anatomy course (p < 0.0001). Age and anxiety coping, but not sex, are predictors of anatomy course grades in DPT students. Mental rotations test scores improved following the anatomy course. The LASSI should be used in other cohorts to identify students with low anxiety subscale scores in order to provide targeted support.
Prognostic differences among Grade Group 4 subgroups in robotic‐assisted radical prostatectomy
Authors: Sasaki Takeshi , Ebara Shin , Tatenuma Tomoyuki , Ikehata Yoshinori , Nakayama Akinori , Kato Daiki , Toide Masahiro , Yoneda Tatsuaki , Sakaguchi Kazushige , Teishima Jun , Makiyama Kazuhide , Kitamura Hiroshi , Saito Kazutaka , Koie Takuya , Koga Fumitaka , Urakami Shinji , Inoue Takahiro 
Published: June 2022

AbstractObjectivesTo investigate whether the International Society of Urological Pathology Grade Group 4 (GG 4) subgroups have different oncological outcomes in Japanese prostate cancer (PCa) patients undergoing robotic‐assisted radical prostatectomy (RARP).Patients and MethodsWe conducted a retrospective multicentre cohort study in PCa patients undergoing RARP at 10 institutions in Japan. Pre‐ and post‐operative variables were collected from enrolled patients. We evaluated biochemical recurrence and clinical and pathological variables in the different GG 4 subgroups.ResultsA total of 3195 patients were enrolled in the study. Among them, 298 patients with GG 4 tumours (pathological Gleason scores [GSs] of 3 + 5 [N = 37], 4 + 4 [N = 257] and 5 + 3 [N = 4]) based on RARP specimens were analysed. The median follow‐up period was 25.2 months. The 3‐year biochemical recurrence (BCR)‐free survival (BCRFS) rate in the overall population was 74.5%. The 3‐year BCRFS rates in the pathological GS 3 + 5, GS 4 + 4 and GS 5 + 3 subgroups were 93.8%, 71.9% and 50.0%, respectively (P = 0.01). In multivariate analysis, pathological GS based on RARP specimens, PSA levels at surgery, pathological T stage, pathological N stage and surgical margins were independent risk factors significantly associated with BCRFS. In particular, patients with pathological GSs 4 + 4 and 5 + 3 were at higher risk of BCR than patients with pathological GS 3 + 5 (hazard ratio 4.54, P = 0.03 and hazard ratio 11.2, P = 0.01, respectively). The study limitations include the lack of central pathological specimen evaluation.ConclusionsFor patients with localized PCa undergoing RARP, pathological GS 4 + 4 and GS 5 + 3 were significantly associated with worse BCRFS than pathological GS 3 + 5. Pathological GS 3 + 5 may be overrated in GG 4. This observation emphasizes that primary and secondary GS should be considered to accurately stratify the risk of BCR after RARP.
Development of targeted gene delivery system based on liposome and PAMAM dendrimer functionalized with hyaluronic acid and TAT peptide: In vitro and in vivo studies
Authors: Ebrahimian Mahboubeh , Hashemi Maryam , Farzadnia Mahdi , Zarei‐Ghanavati Siamak , Malaekeh‐Nikouei Bizhan 
Published: June 2022

AbstractThe development of gene delivery systems is essential to improve their transfection efficiency and cytotoxicity. Combination of lipid and polymeric nanoparticles with the characteristics of both systems have been considered as a next‐generation gene delivery platform. In the current study, we designed a novel and efficient targeted gene delivery system based on liposome and PAMAM dendrimer in cancer cells. Two polymeric formulations containing polyamidoamine‐TAT (PAMAM‐TAT) and PAMAM‐TAT‐Hyaluronic acid (HA) and two lipopolymeric carriers including PAMAM‐TAT‐Liposome and PAMAM‐TAT‐HA‐Liposome were complexed with the enhanced green fluorescent protein (EGFP) plasmid and then evaluated in terms of physicochemical characteristics. The cytotoxicity and transfection efficiency of these synthetized carriers were accomplished against murine colon carcinoma cell line (C26). The biodistribution of polyplexes and lipoployplexes was also evaluated in the C26 tumor bearing mice. The results showed no significant toxicity for all designed nanoparticles (NPs) in C/P4. The highest gene expression was observed using lipopolyplex PAMAM‐TAT‐HA‐Liposome in C/P4 (ratio polymer/DNA; wt/wt). Biodistribution study demonstrated more aggregation of targeted lipopolyplex in tumor cells than other nanoparticles (NPs). It could be concluded that the developed targeted lipopolymeric complex could serve as promising nanotherapeutic system for gene therapy.
Comparing reflective and supportive scaffolding in 3D computer‐aided design course: Engineering students' metacognitive strategies, spatial ability self‐efficacy, and spatial anxiety
Authors: Atman Uslu Nilüfer , Yildiz Durak Hatice , AY Gökçe Mehmet 
Published: June 2022

AbstractThree‐dimensional (3D) modeling provides a suitable context for the improvement of students' higher order thinking skills as it involves challenging and complex learning tasks. For students to succeed in difficult learning tasks, it is necessary to determine the effects of the scaffolding type given to the students in the learning process. This study asserts that reflective and supportive scaffolding has a critical effect on the dependent variables. Reflective scaffolding enables students to explain their reflective processes and clarify their reflective behavior, using personal reflection as a learning tool. Supportive scaffolding provides a process to develop knowledge and guidance on what participants should consider. This study compares the effects of different scaffolding types (reflective or supportive), students' prior knowledge on students' use of metacognitive strategies, spatial ability self‐efficacy, and spatial anxiety in the 3D computer‐aided design course. A pretest and posttest 2 x 2 x 2 factorial quasi‐experimental model was used in the study. This study was carried out with 118 undergraduate mechanical engineering students. Analysis of covariance (ANCOVA) was used in the analysis of the data. The results showed that the supportive scaffolding group scored higher in the metacognitive strategies variable than the reflective scaffolding group. The supportive scaffolding group showed higher spatial ability than the reflective scaffolding group. This study provides engineering educators with an overview of the use of scaffolding types, their effects on the effectiveness of learning environments, and the design of these environments.
Virtual reconstruction of the ancient city of Karakorum
Authors: Khorloo Oyundolgor , Ulambayar Erdenebat , Altantsetseg Enkhbayar 
Published: June 2022

AbstractRuins of ancient cities hold valuable information for historians and archeologists and it allows them to learn about the society and culture of these cities. This paper explores the first attempt to virtually rebuild the historic city of Karakorum based on ruins and archeological findings from the 13th century AD. Further, the analytical and practical methods used to discover its unique urban planning and architectural form by reconstructing the city using various resources from archeological documents to historical science documents are introduced. We explore a digitized version of Karakorum city in an immersive and embodied manner because of the latest technological advances in virtual reality, and this allows us to conserve and visualize its cultural heritage. The research objectives of this study are to (1) create a three‐dimensional visual model of the Karakorum city as close as possible to its real counterpart, and (2) use a game engine as a development platform for integration and interactive visualization.
CNT modified by mesoporous carbon anchored by Ni nanoparticles for CO2 electrochemical reduction
Authors: Du Juan , Chen Aibing , Hou Senlin , Guan Jing 
Published: June 2022

AbstractThe design of novel catalysts for efficient electroreduction of CO2 into value‐added chemicals is a promising approach to alleviate the energy crisis. Herein, we successfully modify the carbon nanotube by a layer of mesoporous carbon shell anchored by nickel (Ni) nanoparticles. Ni species effectively enable carbon deposition derived from pyrolysis of surfactant 1‐hexadecyl trimethyl ammonium bromide to form a mesoporous carbon shell. At the same time, Ni nanoparticles can be embedded in the mesoporous carbon shell due to the confinement effect. Owing to the dispersive Ni nanoparticles and N‐doping active sites of mesoporous carbon, the as‐prepared electrocatalyst exhibits exciting catalytic performance for the selective reduction of CO2 to carbon monoxide (CO) with a maximum Faradaic efficiency of 98% at a moderate overpotential of −0.81 V (vs. reversible hydrogen electrode) and a high partial current density of 60 mA cm−2 in H‐cell with an aqueous electrolyte.
Localized‐domains staging structure and evolution in lithiated graphite
Authors: Weng Suting , Wu Siyuan , Liu Zepeng , Yang Gaojing , Liu Xiaozhi , Zhang Xiao , Zhang Chu , Liu Qiuyan , Huang Yao , Li Yejing , Ateş Mehmet N. , Su Dong , Gu Lin , Li Hong , Chen Liquan , Xiao Ruijuan , Wang Zhaoxiang , Wang Xuefeng 
Published: June 2022

AbstractIntercalation provides to the host materials a means for controlled variation of many physical/chemical properties and dominates the reactions in metal‐ion batteries. Of particular interest is the graphite intercalation compounds with intriguing staging structures, which however are still unclear, especially in their nanostructure and dynamic transition mechanism. Herein, the nature of the staging structure and evolution of the lithium (Li)‐intercalated graphite was revealed by cryogenic‐transmission electron microscopy and other methods at the nanoscale. The intercalated Li‐ions distribute unevenly, generating local stress and dislocations in the graphitic structure. Each staging compound is found macroscopically ordered but microscopically inhomogeneous, exhibiting a localized‐domains structural model. Our findings uncover the correlation between the long‐range ordered structure and short‐range domains, refresh the insights on the staging structure and transition of Li‐intercalated/deintercalated graphite, and provide effective ways to enhance the reaction kinetic in rechargeable batteries by defect engineering.
Amino‐Acid‐Induced Circular Polarized Luminescence in One‐Dimensional Manganese(II) Halide Hybrid
Authors: Xuan Hong‐Li , Sang Yu‐Feng , Xu Liang‐Jin , Zheng Da‐Sheng , Shi Cui‐Mi , Chen Zhong‐Ning 
Published: June 2022

AbstractCircular polarized luminescence (CPL)‐active materials attract great attentions owing to their widely applications in 3D optical displays and encrypted transmission. Inspired by the strategies adopted in perovskite based CPL materials, herein, CPL‐active hybrids (D)‐ and (L)‐(tert‐butyl prolinate)MnCl3 were successfully prepared by assembling chiral D/L tert‐butyl prolinate with manganese (II) chloride. Single crystal structures show the as‐formed hybrids possess one‐dimensional (1D) structure containing linear chains of face‐sharing MnCl6 octahedral surrounded by prolinate cations. The 1D Mn(II) hybrids display strong red emission peaked at 646 nm with PLQY of 67.1 % and 57.2 % for d‐type and l‐type, respectively, representing the highest PLQY for 1D MnII hybrids. Interestingly, the 1D Mn(II) hybrids exhibit prominent circular dichroism (CD) signals and remarkable CPL activity with the dissymmetry factor g of 6.1*10−3 and −6.3*10−3 from 550 to 800 nm for (D)‐ and (L)‐(tert‐butyl prolinate)MnCl3, respectively, owing to the existence of chiral cations. It is worthy noted the obtained g represents the highest value for non‐lead organic–inorganic hybrids.
Overview of recent advances in Vero cells genomic characterization and engineering for high‐throughput vaccine manufacturing
Authors: Sène Marie‐Angélique , Xia Yu , Kamen Amine Abdelkader 
Published: June 2022

AbstractBackgroundThe Vero cell line is the most used continuous cell line for viral vaccine manufacturing with more than 30 years of accumulated experience in the vaccine industry. Nonetheless, virus production yield with Vero cells remains limited. Therefore, given Vero cell line infection susceptibility to a wide range of viruses, alleviating limitations of viral replication and increasing production kinetics in Vero cells could significantly reduce vaccine production time and cost.Here we review the literature on the development of Vero cells as the most effective manufacturing platform for viral vaccines. Whereas various bioprocess development strategies were proposed to improve the production, this review focuses on the genomic characterization and genetic engineering aspects of Vero cells. Rational design of production cell line emerged as a state‐of‐the‐art approach to significantly enhance Vero cell viral production yield and adaptation to suspension culture which aligns with the global preparedness efforts to accelerate and intensify vaccine production capacity to better respond to pandemic situations and epidemic outbreaks.ConclusionUntil recently, the lack of a reference genome for the Vero cell line has limited the understanding of Vero cells behavior in defined culture conditions as well as host‐virus interactions underlying the affinity of the Vero cell line with emerging and re‐emerging pathogens. Importantly this limited our ability to re‐design high‐yield vaccine production processes using Vero genome editing.
Salvage surgery in recurrent sinonasal cancers: Proposal for a prognostic model based on clinicopathologic and treatment‐related parameters
Authors: Mattavelli Davide , Tomasoni Michele , Ferrari Marco , Compagnoni Alessandra , Schreiber Alberto , Taboni Stefano , Rampinelli Vittorio , Marazzi Elisa , Raffetti Elena , Redaelli de Zinis Luca Oscar , Deganello Alberto , Maroldi Roberto , Bossi Paolo , Piazza Cesare , Nicolai Piero 
Published: June 2022

AbstractBackgroundEvidence on survival and major prognosticators after salvage surgery in recurrent sinonasal cancers (SNC) is limited.MethodsA retrospective, single‐center study of recurrent SNC treated with salvage surgery between 1997 and 2019 was conducted. Univariate and multivariable analyses were performed to define a prognostic score for overall survival (OS).ResultsOne hundred and eighteen patients were included. Recurrent SNC originated mostly in the naso‐ethmoidal box (67.8%) and were mainly epithelial (76.2%), high‐grade (49.2%), and locally advanced (rpT4, 60.1%) malignancies. Negative margins were achieved in 56.6% of cases. Two‐ and 5‐year OS were 71.7% and 56%, respectively. The prognostic model included treatment modality for primary tumor, histology, rpT class, margin status, perineural invasion, and adjuvant radiotherapy and stratified patients into three prognostic groups (5‐year OS: 84.4%, 44.9%, and 0%, respectively).ConclusionsTreatment of recurrent SNC can result in good long‐term survival estimates with limited morbidity. Our score can provide excellent prognostic stratification.
Aiding early clinical drug development by elucidation of the relationship between tumor growth inhibition and survival in relapsed/refractory multiple myeloma patients
Authors: Cheng Yiming , Hong Kevin , Chen Nianhang , Yu Xin , Peluso Teresa , Zhou Simon , Li Yan 
Published: June 2022

AbstractEarly prognosis of clinical efficacy is an urgent need for oncology drug development. Herein, we systemically examined the quantitative approach of tumor growth inhibition (TGI) and survival modeling in the space of relapsed and refractory multiple myeloma (MM), aiming to provide insights into clinical drug development. Longitudinal serum M‐protein and progression‐free survival (PFS) data from three phase III studies (N = 1367) across six treatment regimens and different patient populations were leveraged. The TGI model successfully described the longitudinal M‐protein data in patients with MM. The tumor inhibition and growth parameters were found to vary as per each study, likely due to the patient population and treatment regimen difference. Based on a parametric time‐to‐event model for PFS, M‐protein reduction at week 4 was identified as a significant prognostic factor for PFS across the three studies. Other factors, including Eastern Cooperative Oncology Group performance status, prior anti‐myeloma therapeutics, and baseline serum ß2‐microglobulin level, were correlated with PFS as well. In conclusion, patient disease characteristics (i.e., baseline tumor burden and treatment lines) were important determinants of tumor inhibition and PFS in MM patients. M‐protein change at week 4 was an early prognostic biomarker for PFS.
Counselor training for Chinese international students in a United States graduate program: Experiences during training and after returning to China
Authors: Jacob Charles J. 
Published: June 2022

AbstractAn interpretative phenomenological analysis explored the experiences of former Chinese international students trained as counselors in a United States‐based program (n = 9), both with respect to training and work experiences upon returning to China. Themes included strong counselor identity, struggles with adapting to mental health policies in China, and complications acclimating to training in the United States. Suggestions for educators include emphasis on international education and adjustments to hiring practices.
Horizontal transmission might be a common route of hepatitis B virus exposure in highly endemic areas
Authors: Zheng Xiao‐Qun , Li Xin , Liu Jing , Shi Liang , Wang Hong‐Zhi , Tian Ke‐Gang , Pan Xiao‐Ben 
Published: June 2022

AbstractHepatitis B virus (HBV) is a common viral pathogen that infects more than a third of the world's population; however, the transmission route remains to be further defined. The 18‐year implementation of the free HBV vaccine for children has greatly changed the prevalence of HBV infection in China, which presents a unique real‐world model for assessing the pattern of HBV transmission. Cross‐sectional data of HBV seromarkers between July 2019 and April 2020 were collected from 53 371 individuals aged 1–60 years in four areas of North to South in Eastern China. Longitudinal data of HBV seromarkers between 2007 and 2020 were collected from 177 adults in an area of South China. The regional‐ and age‐specific changes in HBV seromarkers were analyzed. Overall, positive rates of HBV surface antigen (HBsAg; from 3.44% to 15.1%) and antibody against HBV core antigen (anti‐HBc; from 7.6% to 44.0%) significantly increased from North to South. Among persons aged ≤18 years, the positive rates of antibody against HBsAg (anti‐HBs) and anti‐HBc (+) remained at low levels in the North, while they were increasing among persons aged >12 years in the South, despite higher positive rates of anti‐HBs (+). Among persons aged >18 years, the anti‐HBs (+) rates remained relatively stable (~60%), while anti‐HBc (+) rates increased significantly with age. Up to ~80% of the anti‐HBs (+) adults in the South was anti‐HBc (+) while it was 13.6% in the North. In the longitudinal cohort, the anti‐HBc (+) rate among adults in the South increased by 14.2% during 10 years of follow‐up. Horizontal transmission might be a common route in highly endemic areas, and may help to explain the high HBV exposure worldwide. The risk of horizontal transmission among children without seroprotective anti‐HBs should be notified in highly endemic areas.
Insight into summer drought in southern Italy: palaeohydrological evolution of Lake Pergusa (Sicily) in the last 6700 years
Authors: Zanchetta Giovanni , Baneschi Ilaria , Magny Michel , Sadori Laura , Termine Rosa , Bini Monica , Vannière Boris , Desmet Marc , Natali Stefano , Luppichini Marco , Pasquetti Francesca 
Published: June 2022

AbstractThe Sicily region (central Mediterranean) is at high risk of drying and desertification caused by current warming and land management. The aim of this study is to place current climatic changes within the past trajectories and natural climatic variability of the Holocene. For this we re‐examine a sediment core retrieved at Lake Pergusa covering the last ca. 6700 years. A multiproxy investigation, and in particular the oxygen isotope composition of lacustrine carbonate (δ18Oc), allowed us to reconstruct decadal‐ to centennial‐scale hydrological changes. The wettest period occurred between ca. 6700 and 6000 cal a bp. The δ18Oc record indicates a new period of wetter conditions between ca. 3700 and 2400 cal a bp. In particular, a δ18Oc minimum between 2850 and 2450 cal a bp overlaps with the period of the ‘Great Solar Minimum’ and corresponds to a dramatic reduction of arboreal pollen (AP%) and to an increase in synanthropic pollen, marking the onset of Greek colonization in the region. The longest driest interval corresponds to the Medieval Climate Anomaly, whereas the highest δ18Oc values are recorded in the last 150 years. The trend of the last 3000 years suggests that, considering future climate projections, the area will experience unprecedented drying exacerbated by human impact.