bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hsa_circ_0005100 regulates tumorigenicity of colorectal carcinoma via miR‐145‐5p/MACC1 axis
Authors: Zhang Tongtong , Yu Suyang , Zhao Shipeng 
Published: June 2022

AbstractBackgroundCircular RNAs (circRNAs) are a kind of RNA molecules involved in the regulation of cancer progression, including colorectal carcinoma (CRC); nevertheless, their regulation mode is blurry. In the present work, we attempted to reveal the characteristics of hsa_hsa_circ_0005100 in CRC.MethodsDifferential expressions of hsa_circ_0005100, FMN2 mRNA, microRNA‐145‐5p (miR‐145‐5p), and MACC1 were indicated by qRT‐PCR and Western blot. The capacities of cell growth and motility were validated by the MTT assay, flow cytometry assay, EdU assay, colony formation assay, and transwell assay. Moreover, the targeted relationship of miR‐145‐5p and hsa_circ_0005100 or MACC1 was distinguished by dual‐luciferase reporter assay. The animal experiment was implemented to confirm the influence of hsa_circ_0005100 on tumorigenesis in vivo.ResultsHsa_circ_0005100 and MACC1 expression levels were increased, but miR‐145‐5p expression level was diminished in CRC. Hsa_circ_0005100 knockdown repressed cell proliferation, cell cycle, migration, and invasion, while expedited cell apoptosis in CRC cells. Furthermore, miR‐145‐5p was disclosed to block CRC via overturning MACC1. Hsa_circ_0005100 targeted miR‐145‐5p to modulate MACC1. Additionally, hsa_circ_0005100 knockdown also attenuated tumorigenesis in vivo.ConclusionHsa_circ_0005100 was a vital regulator in the development of CRC by miR‐145‐5p/MACC1 axis, which deepened the understanding of CRC pathogenesis from circRNA insights.
A review on advances in synthetic methodology and biological profile of spirothiazolidin‐4‐ones
Authors: Yadav Jyoti , Chaudhary Ram Pal 
Published: June 2022

AbstractHeterocycles are important structural components in pharmacophores that are currently being used to treat several diseases. Among the various heterocyclic scaffolds, nitrogen and sulfur containing spiroheterocycles are essential structural motifs that constitute diverse biodynamic agents. In the last two decades, a paradigm shift has occurred in the synthesis of spirothiazolidin‐4‐ones by replacing conventional and multi‐step synthesis with green protocols, that use novel organo and nanocatalysts. In this review, literature on spirothiazolidin‐4‐ones from years 2000–2021 has been summarized into groups of different synthetic strategies and their potential biological activities.
Catalyst‐free one‐pot synthesis of quinoline tethered α‐amino ketones by multicomponent reactions
Authors: Yadav Rahul , Darakshan  , Parvin Tasneem 
Published: June 2022

AbstractHerein we have reported a one‐pot green methodology for the synthesis of quinoline tethered α‐amino ketones. The reaction of arylglyoxal, 2‐aminoquinoline, and 4‐hydroxy‐1‐methylquinolin‐2(1H)‐one/barbituric acid in ethanol under reflux conditions provided the quinoline tethered α‐amino ketones. The environmentally benign process, one‐pot synthesis, readily available starting materials, short reaction time, easy purification process, good yields of the products, and the presence of several bioactive moieties such as quinolines and α‐amino carbonyl in the product are the main advantages of this methodology. All the products were characterized by Fourier transform infrared (FTIR), nuclear magnetic resonance (1H NMR), 13C NMR, and high‐resolution mass spectrometry (HRMS). Single‐crystal X‐ray diffraction (XRD) of one compound was also reported.
A 25‐year climatology of low‐tropospheric temperature and humidity inversions for contrasting synoptic regimes at Neumayer Station, Antarctica
Authors: Silva Tiago , Schlosser Elisabeth , Lehner Manuela 
Published: June 2022

AbstractA 25‐year set of daily radiosonde data was used to investigate temperature and humidity inversions at Neumayer Station, coastal Dronning Maud Land, Antarctica. For the first time, inversions were studied differentiating between different synoptic conditions and different height levels. It was shown that, generally, inversions occurred on the majority (78%) of the days, with simultaneous occurrence of humidity and temperature inversions being observed on approximately two thirds of all days. Multiple inversions are common in all seasons for cyclonic and noncyclonic conditions, however, typically occur more frequently under cyclonic conditions. The seasonality of inversion occurrence and features, that is, inversion strength, depth and vertical gradients, was analysed statistically. Different formation mechanisms depending on inversion levels and prevailing weather situations are related to typical annual courses of certain inversion features. Winter maxima were found for the features that are mostly connected to the temperature close to the surface, which is mainly a result of the negative energy balance, thus influencing surface‐based inversions. At the second level, both temperature and humidity inversions are often caused by advection of comparably warm and moist air masses related to the passage of cyclones and their frontal systems. Hence, maxima in several inversion features are found in spring and fall, when cyclonic activity is strongest. Monthly mean profiles of humidity and temperature inversions reveal that elevated inversions are often obscured in average profiles due to large variations in inversion height and depth.
Tailor‐Made 3D Printed Meshes of Alginate‐Waterborne Polyurethane as Suitable Implants for Hernia Repair
Authors: Olmos‐Juste Raquel , Olza Sheila , Gabilondo Nagore , Eceiza Arantxa 
Published: June 2022

AbstractHernia injuries are the main condition where mesh implants are needed to provide a suitable reinforcement of the damaged tissue. Mesh implants made of polypropylene (PP) are widely used for this application, however complications related to lack of flexibility, elasticity, and mesh infection have been reported. The development of mesh implants from safer materials adaptable to patient necessities can suppose an alternative for conventional PP meshes. In this work, personalized mesh implants made of alginate and waterborne‐polyurethane (A‐WBPU) are developed using 3D printing technology. For that purpose, five waterborne polyurethane ink formulations with different amounts of alginate are developed and rheologically characterized. All ink formulations are 3D printed showing good printability, manufacturing surgical mesh implants with suitable morphological characteristics customizable to patient injury through computer‐aided design (CAD) mesh model adaptation. A calcium chloride (CaCl2) coating is applied after 3D printing as mesh reinforcement. Mechanical analysis revealed that CaCl2 coated meshes containing 6 wt % of alginate in their formulation are the most suitable to be used as implants for small and groin hernias under physiological tensile strength value of 16 N cm−1, and presenting proper elasticity to cover physiological corporal movements (42.57 %). Moreover, an antibiotic‐loaded A‐WBPU formulation suitable for 3D printing of meshes are developed as strategy to avoid possible mesh infection.
Inhibitory effect of cysteine and lanthanides on AA7075‐T6 in neutral NaCl solution
Authors: Pejić Jovanka , Radojković Bojana , Marunkić Dunja , Jegdić Bore , Stevanović Sanja , Milošević Milena , Bajat Jelena 
Published: June 2022

AbstractThe inhibitory effect of cysteine in the presence of selected lanthanide chlorides (LaCl3, NdCl3, and CeCl3) in a neutral 0.1 M NaCl solution was analyzed. The cysteine concentration of 0.3 mM was determined as an optimal one. The resistance to general and pitting corrosion of AA7075‐T6 alloy in inhibitive solutions was determined using electrochemical impedance spectroscopy and potentiodynamic polarization measurements. The surface appearance of the aluminum alloy was determined before and after corrosion tests using scanning electron microscopy/energy dispersive spectroscopy, while the presence of an inhibitory layer on the alloy surface was confirmed by X‐ray photoelectron spectroscopy analysis and atomic force microscopy. The inhibitory effect of cysteine was significantly higher in the presence of all tested lanthanide chlorides, especially to pitting corrosion. The protective ability of cysteine was increased by lanthanides in the following sequence: Ln < Nd < Ce ions. The inhibitory effect of cysteine in the presence of cerium ions was examined in more detail as cerium ions provided the highest inhibitory effect, both to general and pitting corrosion.
Thermosensitive P(AAc‐co‐NIPAm) Hydrogels Display Enhanced Toughness and Self‐Healing via Ion–Ligand Interactions
Authors: Xu Lin , Fu Yu , Wagner Robert J. , Zou Xiang , He Qingrui , Li Tao , Pan Wenlong , Ding Jianning , Vernerey Franck J. 
Published: June 2022

AbstractHydrogels containing thermosensitive polymers such as poly(N‐isopropylacrylamide) (P(NIPAm)) may contract during heating and show great promise in fields ranging from soft robotics to thermosensitive biosensors. However, these gels often exhibit low stiffness, tensile strength, and mechanical toughness, limiting their applicability. Through copolymerization of P(NIPAm) with poly(Acrylic acid) (P(AAc)) and introduction of ferric ions (Fe3+) that coordinate with functional groups along the P(AAc) chains, here a thermoresponsive hydrogel with enhanced mechanical extensibility, strength, and toughness is introduced. Using both experimentation and constitutive modeling, it is found that increasing the ratio of m(AAc):m(NIPAm) in the prepolymer decreases strength and toughness but improves extensibility. In contrast, increasing Fe3+ concentration generally improves strength and toughness with little decrease in extensibility. Due to reversible coordination of the Fe3+ bonds, these gels display excellent recovery of mechanical strength during cyclic loading and self‐healing ability. While thermosensitive contraction imbued by the underlying P(NIPAm) decreases slightly with increased Fe3+ concentration, the temperature transition range is widened and shifted upward toward that of human body temperature (between 30 and 40 °C), perhaps rendering these gels suitable as in vivo biosensors. Finally, these gels display excellent adsorptive properties with a variety of materials, rendering them possible candidates in adhesive applications.
Single‐shot T2 mapping via multi‐echo‐train multiple overlapping‐echo detachment planar imaging and multitask deep learning
Authors: Ouyang Binyu , Yang Qizhi , Wang Xiaoyin , He Hongjian , Ma Lingceng , Yang Qinqin , Zhou Zihan , Cai Shuhui , Chen Zhong , Wu Zhigang , Zhong Jianhui , Cai Congbo 
Published: June 2022

AbstractBackgroundQuantitative magnetic resonance imaging provides robust biomarkers in clinics. Nevertheless, the lengthy scan time reduces imaging throughput and increases the susceptibility of imaging results to motion. In this context, a single‐shot T2 mapping method based on multiple overlapping‐echo detachment (MOLED) planar imaging was presented, but the relatively small echo time range limits its accuracy, especially in tissues with large T2.PurposeIn this work we proposed a novel single‐shot method, Multi‐Echo‐Train Multiple OverLapping‐Echo Detachment (METMOLED) planar imaging, to accommodate a large range of T2 quantification without additional measurements to rectify signal degeneration arisen from refocusing pulse imperfection.MethodsMultiple echo‐train techniques were integrated into the MOLED sequence to capture larger TE information. Maps of T2, B1, and spin density were reconstructed synchronously from acquired METMOLED data via multitask deep learning. A typical U‐Net was trained with 3000/600 synthetic data with geometric/brain patterns to learn the mapping relationship between METMOLED signals and quantitative maps. The refocusing pulse imperfection was settled through the inherent information of METMOLED data and auxiliary tasks.ResultsExperimental results on the digital brain (structural similarity (SSIM) index = 0.975/0.991/0.988 for MOLED/METMOLED‐2/METMOLED‐3, hyphenated number denotes the number of echo‐trains), physical phantom (the slope of linear fitting with reference T2 map = 1.047/1.017/1.006 for MOLED/METMOLED‐2/METMOLED‐3), and human brain (Pearson's correlation coefficient (PCC) = 0.9581/0.9760/0.9900 for MOLED/METMOLED‐2/METMOLED‐3) demonstrated that the METMOLED improved the quantitative accuracy and the tissue details in contrast to the MOLED. These improvements were more pronounced in tissues with large T2 and in application scenarios with high temporal resolution (PCC = 0.8692/0.9465/0.9743 for MOLED/METMOLED‐2/METMOLED‐3). Moreover, the METMOLED could rectify the signal deviations induced by the non‐ideal slice profiles of refocusing pulses without additional measurements. A preliminary measurement also demonstrated that the METMOLED is highly repeatable (mean coefficient of variation (CV) = 1.65%).ConclusionsMETMOLED breaks the restriction of echo‐train length to TE and implements unbiased T2 estimates in an extensive range. Furthermore, it corrects the effect of refocusing pulse inaccuracy without additional measurements or signal post‐processing, thus retaining its single‐shot characteristic. This technique would be beneficial for accurate T2 quantification.
Visual versus quantitative analysis of muscle ultrasound in neuromuscular disease
Authors: Wijntjes Juerd , van der Hoeven Joris , Saris Christiaan G. J. , Doorduin Jonne , van Alfen Nens 
Published: June 2022

AbstractIntroduction/AimsVisual and quantitative muscle ultrasound are both valid diagnostic tools in neuromuscular diseases. To optimize muscle ultrasound evaluation and facilitate its use in neuromuscular disease, we examined the correlation between visual and quantitative muscle ultrasound analysis and their pitfalls.MethodsRetrospective data from 994 patients with 13,562 muscle ultrasound images were analyzed. Differences in echogenicity z‐score distribution per Heckmatt grade and corresponding correlation coefficients were calculated.ResultsOverall, there was a correlation of 0.60 between the two scoring systems, with a gradual increase in z‐score with increasing Heckmatt grades and vice versa. Patients with a neuromuscular disorder had higher Heckmatt grades (p < 0.001) and z‐scores (median z‐score = 0.30, p < 0.001) than patients without. The highest Heckmatt grades and z‐scores were found in patients with either a dystrophy or inflammatory myopathy (both median Heckmatt grade of 2 and median z score of 0.74 and 1.20, respectively). Discrepant scores were infrequent (<2%), but revealed important pitfalls in both grading systems.DiscussionVisual and quantitative muscle ultrasound are complementary techniques to evaluate neuromuscular disease and have a moderate positive correlation. Importantly, we identified specific pitfalls for visual and quantitative muscle ultrasound and how to overcome them in clinical practice.
Impact of deep learning architectures on accelerated cardiac T1 mapping using MyoMapNet
Authors: Amyar Amine , Guo Rui , Cai Xiaoying , Assana Salah , Chow Kelvin , Rodriguez Jennifer , Yankama Tuyen , Cirillo Julia , Pierce Patrick , Goddu Beth , Ngo Long , Nezafat Reza 
Published: June 2022

The objective of the current study was to investigate the performance of various deep learning (DL) architectures for MyoMapNet, a DL model for T1 estimation using accelerated cardiac T1 mapping from four T1‐weighted images collected after a single inversion pulse (Look‐Locker 4 [LL4]). We implemented and tested three DL architectures for MyoMapNet: (a) a fully connected neural network (FC), (b) convolutional neural networks (VGG19, ResNet50), and (c) encoder‐decoder networks with skip connections (ResUNet, U‐Net). Modified Look‐Locker inversion recovery (MOLLI) images from 749 patients at 3 T were used for training, validation, and testing. The first four T1‐weighted images from MOLLI5(3)3 and/or MOLLI4(1)3(1)2 protocols were extracted to create accelerated cardiac T1 mapping data. We also prospectively collected data from 28 subjects using MOLLI and LL4 to further evaluate model performance. Despite rigorous training, conventional VGG19 and ResNet50 models failed to produce anatomically correct T1 maps, and T1 values had significant errors. While ResUNet yielded good quality maps, it significantly underestimated T1. Both FC and U‐Net, however, yielded excellent image quality with good T1 accuracy for both native (FC/U‐Net/MOLLI = 1217 ± 64/1208 ± 61/1199 ± 61 ms, all p < 0.05) and postcontrast myocardial T1 (FC/U‐Net/MOLLI = 578 ± 57/567 ± 54/574 ± 55 ms, all p < 0.05). In terms of precision, the U‐Net model yielded better T1 precision compared with the FC architecture (standard deviation of 61 vs. 67 ms for the myocardium for native [p < 0.05], and 31 vs. 38 ms [p < 0.05], for postcontrast). Similar findings were observed in prospectively collected LL4 data. It was concluded that U‐Net and FC DL models in MyoMapNet enable fast myocardial T1 mapping using only four T1‐weighted images collected from a single LL sequence with comparable accuracy. U‐Net also provides a slight improvement in precision.
Free energy calculation and ghost force correction for hot‐QC
Authors: Kim Woo Kyun , Kavalur Aditya , Whalen Stephen M. , Tadmor Ellad B. 
Published: June 2022

AbstractA new efficient variant of hot‐QC, the finite temperature version of the quasicontinuum (QC) method, is presented. In the original formulation of hot‐QC, a dynamically evolving atomistic region is coupled with either a dynamic (hot‐QC‐dynamic) or a static (hot‐QC‐static) continuum region. In the current work, a free energy minimization method is employed in which atom positions in both the atomistic and continuum regions always occupy equilibrium positions. The effect of ghost forces at the interface of the atomistic and continuum regions is discussed for all three variants of hot‐QC using two examples: a perfect cubic crystal and a Lomer dislocation dipole. Errors due to ghost forces and due to mesh entropy are considered and the efficacy of their correction terms are evaluated. It is shown that the proposed free energy minimization method has comparable accuracy to the other methods with significantly higher efficiency.
Compatibility of mycorrhiza‐induced resistance with viral and bacterial entomopathogens in the control of Spodoptera exigua in tomato
Authors: Frattini Ada , Martínez‐Solís María , Llopis‐Giménez Ángel , Pozo María J. , Rivero Javier , Crava Cristina M. , Herrero Salvador 
Published: June 2022

AbstractBACKGROUNDArbuscular mycorrhizal fungi (AMF) are soil‐borne microorganisms that establish mutualistic associations with roots of most terrestrial plants. This symbiosis results in nutritional and defensive benefits to the host plant, usually conferring protection against biotic stresses, but its indirect impact on third trophic levels is still unknown. In the present work, we explore whether the symbiosis of tomato plants with Funneliformis mosseae (and/or exposition to herbivory) influences the interaction of the generalist pest Spodoptera exigua (Lepidoptera: Noctuidae) with bacterial (Bacillus thuringiensis) and viral (baculovirus, SeMNPV) natural entomopathogens.RESULTSSymbiosis with AMF and previous herbivory reduces the relative growth of S. exigua, increases its susceptibility to a sublethal dose of B. thuringiensis and has positive or neutral impact on the lethality of SeMNPV. Reduction of the phenoloxidase activity, a marker of the insect immune response, was associated with the larval feeding on plant material previously exposed to herbivory but not to the AMF. In addition, no changes in the insect gut microbiota could be associated with the observed changes in larval growth and susceptibility to the entomopathogens.CONCLUSIONOur findings provide the first evidence of compatibility of AMF symbiosis in tomato with the use of bacterial and viral entomopathogens, contributing to the development of novel approaches to combine the beneficial effect of AMF and entomopathogens in biological pest control. © 2022 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Polydatin alleviates DSS‐ and TNBS‐induced colitis by suppressing Th17 cell differentiation via directly inhibiting STAT3
Authors: Liu Yao‐Jun , Xu Wei‐Heng , Fan Li‐Ming , Zhang Yu‐Qin , Xu Wen , Chen Ya‐Ping , Chen Lin‐Lin , Chen Li , Xu Wei , Wang Yan , Chu Ke‐Dan , Zhang Jun‐Ping 
Published: June 2022

AbstractInflammatory bowel disease (IBD) is a non‐specific chronic intestinal inflammatory disease, often presenting with abdominal pain, diarrhea, bloody stool, anorexia, and body loss. It is difficult to cure completely and a promising treatment is urgently needed. Natural compounds can offer promising chemical agents for treatment of diseases. Polydatin is a natural ingredient extracted from the dried rhizome of Polygonum cuspidatum, which has anti‐inflammatory, anti‐tumor, and dementia protection activities. The purpose of this study was to evaluate the therapeutic effect of polydatin on IBD and explore its possible mechanism. We found that polydatin could effectively suppress the differentiation of Th17 cells in vitro, but had no effect on the differentiation of Treg cells. Polydatin significantly alleviated colitis induced by dextran sulfate sodium (DSS) and 2, 4, 6‐trinitrobenzenesulfonic acid (TNBS) in mice, and dramatically decreased the proportion of Th17 cells in spleen and mesenteric lymph nodes. Mechanism investigations revealed that polydatin specifically inhibited signal transducer and activator of transcription 3 (STAT3) phosphorylation by directly binding to STAT3, leading to Th17 cell reduction and thereby alleviating colitis. These findings provide novel insights into the anti‐colitis effect of polydatin, which may be a promising drug candidate for the treatment of IBD.
Molecular Vibrational Polaritons Towards Quantum Technologies
Authors: Yang Zimo , Xiong Wei 
Published: June 2022

AbstractMolecular vibrational polaritons (MVPs)—a hybrid molecular‐photon quasiparticle—and the development of a proof‐of‐principle quantum technology platform are discussed to simulate coherence transfer, for use at room temperature. It is shown that MVPs can form qubits, coherence, and have nonlinear interactions, all at room temperature. Some new insights, such as polaritonic nonlinearity dependence on macroscopic properties including cavity thickness and molecular concentrations are also uncovered. It is hoped that these advances can stimulate more research in developing this system into a quantum technology platform free from the constraints imposed by the requirement of cryogenic conditions.
Stabilization and disturbance rejection with decay rate bounding in discrete‐time linear parameter‐varying systems via ℋ∞gain‐scheduling static output feedback control
Authors: Sereni Bruno , Assunção Edvaldo , Teixeira Marcelo Carvalho Minhoto 
Published: June 2022

AbstractThe stabilization of discrete‐time linear parameter‐varying (LPV) systems via gain‐scheduling static output feedback (SOF) control is addressed in this article. We propose new sufficient linear matrix inequalities (LMI) conditions for synthesizing a gain‐scheduled SOF controller that ensures asymptotic stability and also imposes a lower bound on the closed‐loop decay rate. The SOF controller design is based on a two‐step method: a state‐feedback controller is obtained in a first‐stage design, which is then used as input information in the second stage for computing the desired gain‐scheduled SOF controller. The proposed LMI constraints are given in terms of the existence of affine parameter‐dependent Lyapunov functions, considering arbitrarily fast variation of the time‐varying parameters. An extension for coping with disturbance rejection is also proposed, in terms of the guaranteed cost optimization. Some numerical experiments are presented to illustrate the control synthesis procedure and its efficacy. Also, feasibility analyses are presented to compare and show the advantages of our results over other available strategies present in literature.