bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Improvement of Neuropsychological Impairments During Detoxification in Patients with Alcohol Use Disorder
Authors: Angerville Bernard , Ritz Ludivine , Pitel Anne-Lise , Beaunieux Hélène , Houchi Hakim , Martinetti Margaret P , Naassila Mickaël , Dervaux Alain 
Published: October 2022

AbstractAimsTo assess recovery of alcohol-related neuropsychological deficits in a group of patients with pure severe alcohol use disorder (AUD) during a detoxification program using the Brief Evaluation of Alcohol-Related Neuropsychological Impairment (BEARNI) test.MethodsThirty-two patients with severe AUD using DSM-IV criteria (24 men, mean age = 45.5 ± 6.8 years old) were assessed using the BEARNI 8 ± 2 days after alcohol cessation (T1) and then were reassessed within 18 ± 2 days after alcohol cessation (T2). The primary study endpoint was the number of patients initially impaired at T1 who recovered cognitive functions at T2 assessment.ResultsAt T1, 59% (n = 19) patients with pure severe AUD had at least one impaired cognitive function assessed by the BEARNI. At T2, 63% of the patients with AUD with deficits at T1 had normal BEARNI cognitive scores (χ2 = 7.7, P = 0.005); specifically, the percentages of participants with normal subtest scores were 63% on memory (χ2 = 12.4, P = 0.0004), 100% on verbal fluency (χ2 = 16; P = &lt;0.0001), 60% on alphabetical span (χ2 = 12.8; P = 0.0003) and 67% on visuospatial (χ2 = 15, P = 0.0001).ConclusionsThe cognitive impairments of two-thirds of patients with pure AUD included in the present study recovered within 18 days of abstinence, earlier than reported in previous studies.
Offending and the Long-Term Risk of Death: An Examination of Mid-Life Mortality Among an Urban Black American Cohort
Authors: Doherty Elaine Eggleston , Green Kerry M 
Published: October 2022

Abstract
Research on the long-term relationship between offending and mortality is limited, especially among minorities who have higher risk of premature mortality and criminal offending, particularly arrest. Using Cox proportional hazard models, we estimate the relationship between young adult offending and later mortality (to age 58) among a community cohort of Black Americans (n = 1,182). After controlling for a wide range of covariates, results indicate that violent offenders are at heightened risk of mortality from young adulthood through midlife compared with both non-violent only offenders and non-offenders. Further analysis shows that this result is driven by the frequent, largely non-violent, arrests incurred among violent offenders. Criminal justice reform and collaboration with public health practitioners might be fruitful avenues to reduce mortality disparities.
Platform power: monopolisation and financialisation in the era of big tech
Authors: Li Zhongjin , Qi Hao 
Published: October 2022

AbstractThis paper addresses the questions of corporate power represented by digital platforms. We undertake a conceptual analysis of platform power so that it can provide an explanation of key motivations and behaviours for monopolisation in the platform economy. We argue that there emerges a hierarchical power structure in which platform companies relentlessly pursue power over users, and small platforms increasingly depend on big tech and financial capital. Drawing theoretical insights from the monopoly capital school and empirical evidence from platform companies in China, this paper further explores the macroeconomic implications of platform monopolisation and financialisation. It is demonstrated that the hierarchical power structure in the platform economy may increase income inequality, exacerbate overcapacity and generate financial instability.
Comparison of hand-sewn and circular stapled esophagogastric anastomoses in the neck after esophagectomy for thoracic esophageal cancer: a propensity score-matched analysis
Authors: Ozawa Hiroki , Kawakubo Hirofumi , Nishimura Erica , Matsuda Satoru , Takemura Ryo , Irino Tomoyuki , Fukuda Kazumasa , Nakamura Rieko , Wada Norihito , Kitagawa Yuko 
Published: October 2022

SummaryEsophagectomy is a highly invasive surgical procedure; however, anastomotic leakage is one of the major surgical complications that should be prevented. Institutions have their own inherited or specialized anastomosis methods. The superior anastomosis procedure remains unknown despite the many studies to determine the optimal method. The present study enrolled 341 patients who underwent esophagectomy at Keio University Hospital, Tokyo, Japan, between January 2009 and January 2019. The anastomosis method was changed from circular stapled anastomosis to hand-sewn anastomosis in February 2014 to reduce the risk of anastomotic leakage. We retrospectively compared short-term results (anastomotic leakage and stricture) between hand-sewn and circular stapled anastomoses. Analysis of heterogeneity after propensity score matching between the 107 patients in the hand-sewn anastomosis group and 107 patients in the circular stapled anastomosis group revealed almost equal distributions. The incidence rate of anastomotic leakage was significantly lower in the hand-sewn anastomosis group than in the circular stapled anastomosis group (9 vs. 20%, hazard ratio: 2.521; 95% confidence interval: 1.112–5.716; P = 0.027). No significant difference was found in the incidence of anastomotic stricture (16 vs. 18%, P = 0.844). Furthermore, no significant difference was found in the incidence of anastomotic leakage in any of the tumor locations between the two anastomosis procedures. For esophagogastric anastomosis in the neck after esophagectomy, hand-sewn anastomosis is superior to circular stapled anastomosis with regard to reducing the risk of anastomotic leakage.
The surgical anatomy of a (robot-assisted) minimally invasive transcervical esophagectomy
Authors: Filz von Reiterdank I C L J , Defize I L , de Groot E M , Wedel T , Grimminger P P , Egberts J H , Stein H , Ruurda J P , van Hillegersberg R , Bleys R L A W 
Published: October 2022

SummaryBACKGROUNDTranscervical esophagectomy allows for esophagectomy through transcervical access and bypasses the thoracic cavity, thereby eliminating single lung ventilation. A challenging surgical approach demands thorough understanding of the encountered anatomy. This study aims to provide a comprehensive overview of surgical anatomy encountered during the (robot-assisted) minimally invasive transcervical esophagectomy (RACE and MICE).METHODSTo assess the surgical anatomy of the lower neck and mediastinum, MR images were made of a body donor after, which it was sliced at 24-μm intervals with a cryomacrotome. Images were made every 3 slices resulting in 3.200 images of which a digital 3D multiplanar reconstruction was made. For macroscopic verification, microscopic slices were made and stained every 5 mm (Mallory-Cason). Schematic drawings were made of the 3D reconstruction to demonstrate the course of essential anatomical structures in the operation field and identify anatomical landmarks.RESULTSSurgical anatomy ‘boxes’ of three levels (superior thoracic aperture, upper mediastinum, subcarinal) were created. Four landmarks were identified: (i) the course of the thoracic duct in the mediastinum; (ii) the course of the left recurrent laryngeal nerve; (iii) the crossing of the azygos vein right and dorsal of the esophagus; and (iv) the position of the aortic arch, the pulmonary arteries, and veins.CONCLUSIONSThe presented 3D reconstruction of unmanipulated human anatomy and schematic 3D ‘boxes’ provide a comprehensive overview of the surgical anatomy during the RACE or MICE. Our findings provide a useful tool to aid surgeons in learning the complex anatomy of the mediastinum and the exploration of new surgical approaches such as the RACE or MICE.
Real-life introduction of powered circular stapler for esophagogastric anastomosis: cohort and propensity matched score study
Authors: Vanstraelen Stijn , Coosemans Willy , Depypere Lieven , Mandeville Yannick , Moons Johnny , Van Veer Hans , Nafteux Philippe 
Published: October 2022

Summary
Anastomotic leakage after esophagectomy is one of the most feared complications, which results in increased morbidity and mortality. Our aim was to evaluate the impact of a powered circular stapler on complications after esophagectomy with intrathoracic anastomosis for esophageal cancer. Between May 2019 and July 2021, all consecutive oesophagectomies for cancer with intrathoracic anastomosis in a high-volume center were included in this retrospective study. Surgeons were free to choose either a manual or a powered circular stapler. Preoperative characteristics and postoperative complications were recorded in a prospective database, according to EsoData. Propensity score matching (age, body mass index, Eastern cooperative oncology group (ECOG) performance and neoadjuvant therapy) was conducted to reduce potential confounding. We included 128 patients. Powered and manual circular staplers were used in 62 and 66 patients, respectively. Fewer anastomotic leakages were observed with the powered stapler group (OR = 7.3 (95%CI: 1.58–33.7); [3.2% (n = 2) vs 19.7% (n = 13), respectively; p = 0.004]). After propensity score matching, this remained statistically significant (OR = 8.5 (95%CI: 1.80–40.1); [4.1% (n = 2) vs 20.4% (n = 10), respectively; p = 0.013]). Additionally, anastomotic diameter was significantly higher with the powered stapler (median: 29 mm (63.3%) vs 25 mm (57.1%), respectively; p &lt; 0.0001). There was no significant difference in comprehensive complication index (p = 0.146). A decreased mean length of stay was observed in the powered stapler group (11.1 vs 18.7 days respectively; p = 0.022). Postoperative anastomotic leakage after esophageal resection was significantly reduced after the introduction of the powered circular stapler, consequently resulting in a reduced length of stay. Further evaluation on long-term strictures and quality of life are warranted to support these results.
Pneumocystis jirovecii Pneumonia in Patients with Inflammatory Bowel Disease–a Case Series
Authors: Vieujean Sophie , Moens Annick , Hassid Deborah , Rothfuss Katja , Savarino Edoardo Vincenzo , Vavricka Stephan R , Reenaers Catherine , Jacobsen Bent Ascanius , Allez Matthieu , Ferrante Marc , Rahier Jean-Francois 
Published: October 2022

Abstract

Background and Aim
Pneumocystis jirovecii pneumonia [PJP] is a very rare, potentially life-threatening pulmonary fungal infection that occurs in immunocompromised individuals including patients with inflammatory bowel disease [IBD]. Our aim was to describe immunosuppressive treatment exposure as well as the outcome in IBD patients with PJP.

Methods
PJP cases were retrospectively collected through the COllaborative Network For Exceptionally Rare case reports of the European Crohn’s and Colitis Organisation. Clinical data were provided through a case report form.

Results
In all, 18 PJP episodes were reported in 17 IBD patients [10 ulcerative colitis and seven Crohn’s disease]. The median age at PJP diagnosis was 55 years (interquartile range [IQR], 40–68 years]. Two PJP [11.1%] occurred in patients on triple immunosuppression, 10 patients [55.6%] had double immunosuppressive treatment, four patients [22.2%] had monotherapy and two PJP occurred in absence of immunosuppressive treatment [one in a human immunodeficiency virus patient and one in a patient with a history of autologous stem cell transplantation]. Immunosuppressive therapies included steroids [n = 12], thiopurines [n = 10], infliximab [n = 4], ciclosporin [n = 2], methotrexate [n = 1], and tacrolimus [n = 1]. None of the patients diagnosed with PJP had received prophylaxis. All patients were treated by trimethoprim/sulphamethoxazole or atovaquone and an intensive care unit [ICU] stay was required in seven cases. Two patients [aged 71 and 32 years] died, and one patient had a recurrent episode 16 months after initial treatment. Evolution was favourable for the others.

Conclusion
This case series reporting potentially fatal PJP highlights the need for adjusted prophylactic therapy in patients with IBD on immunosuppressive therapy.
Patient-reported outcomes via electronic health record portal versus telephone: a pragmatic randomized pilot trial of anxiety or depression symptoms in epilepsy
Authors: Munger Clary Heidi M , Snively Beverly M , Topaloglu Umit , Duncan Pamela , Kimball James , Alexander Halley , Brenes Gretchen A 
Published: October 2022

AbstractObjectiveTo close gaps between research and clinical practice, tools are needed for efficient pragmatic trial recruitment and patient-reported outcome collection. The objective was to assess feasibility and process measures for patient-reported outcome collection in a randomized trial comparing electronic health record (EHR) patient portal questionnaires to telephone interview among adults with epilepsy and anxiety or depression symptoms.Materials and MethodsRecruitment for the randomized trial began at an epilepsy clinic visit, with EHR-embedded validated anxiety and depression instruments, followed by automated EHR-based research screening consent and eligibility assessment. Fully eligible individuals later completed telephone consent, enrollment, and randomization. Participants were randomized 1:1 to EHR portal versus telephone outcome assessment, and patient-reported and process outcomes were collected at 3 and 6 months, with primary outcome 6-month retention in EHR arm (feasibility target: ≥11 participants retained).ResultsParticipants (N = 30) were 60% women, 77% White/non-Hispanic, with mean age 42.5 years. Among 15 individuals randomized to EHR portal, 10 (67%, CI 41.7%–84.8%) met the 6-month retention endpoint, versus 100% (CI 79.6%–100%) in the telephone group (P = 0.04). EHR outcome collection at 6 months required 11.8 min less research staff time per participant than telephone (5.9, CI 3.3–7.7 vs 17.7, CI 14.1–20.2). Subsequent telephone contact after unsuccessful EHR attempts enabled near complete data collection and still saved staff time.DiscussionIn this randomized study, EHR portal outcome assessment did not meet the retention feasibility target, but EHR method saved research staff time compared to telephone.ConclusionWhile EHR portal outcome assessment was not feasible, hybrid EHR/telephone method was feasible and saved staff time.
Clinical, technical, and implementation characteristics of real-world health applications using FHIR
Authors: Griffin Ashley C , He Lu , Sunjaya Anthony P , King Andrew J , Khan Zubin , Nwadiugwu Martin , Douthit Brian , Subbian Vignesh , Nguyen Viet , Braunstein Mark , Jaffe Charles , Schleyer Titus 
Published: October 2022

Abstract

Objective
Understanding the current state of real-world Fast Healthcare Interoperability Resources (FHIR) applications (apps) will benefit biomedical research and clinical care and facilitate advancement of the standard. This study aimed to provide a preliminary assessment of these apps’ clinical, technical, and implementation characteristics.

Materials and Methods
We searched public repositories for potentially eligible FHIR apps and surveyed app implementers and other stakeholders.

Results
Of the 112 apps surveyed, most focused on clinical care (74) or research (45); were implemented across multiple sites (56); and used SMART-on-FHIR (55) and FHIR version R4 (69). Apps were primarily stand-alone web-based (67) or electronic health record (EHR)-embedded (51), although 49 were not listed in an EHR app gallery.

Discussion
Though limited in scope, our results show FHIR apps encompass various domains and characteristics.

Conclusion
As FHIR use expands, this study—one of the first to characterize FHIR apps at large—highlights the need for systematic, comprehensive methods to assess their characteristics.
Coke of Norfolk: politician, agriculturalist and art collector
Authors: Hardwick Katherine 
Published: October 2022

Abstract
While much has been written about the collecting practices of Thomas Coke, 1st Earl of Leicester of the 5th Creation (1697–1759), less attention has been paid to those of his successor Thomas William Coke, later 1st Earl of Leicester of the 7th Creation (1754–1842). The first Thomas Coke was responsible for the construction and decoration of Holkham Hall in Norfolk. He was a passionate and enlightened collector, celebrated for his artistic contribution to Holkham. By contrast, biographers of Thomas William Coke have tended to focus on his career as a parliamentarian and agricultural reformer. This article seeks to redress that imbalance and examine the collecting habits of Thomas William Coke to demonstrate that he was an equally able collector, and to situate his collecting habits within the context of his time.
Falsely Elevated Estradiol Results in a 62-Year-Old Male Patient
Authors: Talaber Gergely , Meisel Tomas , Rosen Thord 
Published: October 2022

Abstract
Falsely increased estradiol levels can lead to unnecessary tests and therapeutic interventions. Here, we present a case of a 62-year-old man with falsely elevated estradiol, which led to subsequent follow-up testing and prescriptions. Alternative immunoassay testing, in conjunction with Scantibodies’ blocking reagents, polyethylene glycol precipitation, and liquid chromatography-tandem mass spectrometry confirmation demonstrated that the falsely elevated estradiol was due to the presence of macro-estradiol. This report emphasizes the importance of recognizing analytical interferences in immunoassays to appropriately manage subsequent testing and patient care.
Living Intimately with Loss: Embodied Memory in Nadia Boulanger’s Post-1918 Work of Mourning
Authors: Rogers Jillian C 
Published: October 2022

ABSTRACT
This article examines and contextualizes Nadia Boulanger’s musical and non-musical mourning practices within fin de siècle French culture, her family history with mourning, and her personal approaches to loss. Through examination of archival materials, including letters, datebooks, and concert programmes, as well as her published writings, I argue that Nadia mourned her sister Lili after her death in 1918 through a set of embodied practices that either viscerally reminded her of Lili or allowed her to resemble an idealized image of her sister. In addition, through analysis of Nadia’s and Lili’s post-1914 compositions in the context of mourning, this article also shows how both Boulanger sisters’ mourning practices and their idiosyncratic, although socio-culturally and spiritually inflected, understandings of loss and grief shaped their musical compositions. By detailing the ways that mourning and musical choices intertwined for Nadia Boulanger, this essay sheds new light on her career, while also demonstrating the importance of considering emotional practices in music history.
Revisit the periodicity of SGR J1935+2154 bursts with updated sample
Authors: Xie Sheng-Lun , Cai Ce , Xiong Shao-Lin , Yu Yun-Wei , Zhang Yan-Qiu , Lin Lin , Zhang Zhen , Xue Wang-Chen , Liu Jia-Cong , Zhao Yi , Xiao Shuo , Zheng Chao , Yi Qi-Bin , Zhang Peng , Wang Ping , Qiao Rui , Peng Wen-Xi , Huang Yue , Ma Xiang , Zhao Xiao-Yun , Li Xiao-Bo , Zheng Shi-Jie , Ge Ming-Yu , Li Cheng-Kui , Li Xin-Qiao , Wen Xiang-Yang , Zhang Fan , Song Li-Ming , Zhang Shuang-Nan , Guo Zhi-Wei , Zhang Xiao-Lu , Zhao Guo-Ying , Li Chao-Yang 
Published: October 2022

ABSTRACT
Since FRB 200428 has been found to be associated with an X-ray burst from the Galactic magnetar SGR J1935+2154, it is interesting to explore whether the magnetar bursts also follow the similar active periodic behaviour as some repeating FRBs. Previous studies show that there is possible period of about 230 days in SGR J1935+2154 bursts. Here, we collected an updated burst sample from SGR J1935+2154, including all bursts reported by Fermi/GBM and GECAM till 2022 January. We also developed a targeted search pipeline to reveal more bursts from SGR J1935+2154 in the Fermi/GBM data from 2008 August to 2014 December (i.e. before the first burst detected by Swift/BAT). With this burst sample, we re-analysed the possible periodicity of SGR J1935+2154 bursts using the Period Folding and Lomb–Scargle Periodogram methods. Our results show that the periodicity ∼238 days reported in literature is probably fake and the observation effects may introduce false periods (i.e. 55 days) according to simulation tests. We find that, for the current burst sample, the most probable period is 126.88 ± 2.05 days, which could be interpreted as the precession of the magnetar. However, we note that the whole burst history is very complicated and difficult to be perfectly accommodated with any period reported thus far, therefore more monitoring observations of SGR J1935+2154 are required to test any periodicity hypothesis.
Loss of MYB34 Transcription Factor Supports the Backward Evolution of Indole Glucosinolate Biosynthesis in a Subclade of the Camelineae Tribe and Releases the Feedback Loop in This Pathway in Arabidopsis
Authors: Czerniawski Paweł , Piślewska-Bednarek Mariola , Piasecka Anna , Kułak Karolina , Bednarek Paweł 
Published: October 2022

Abstract
Glucosinolates are specialized defensive metabolites characteristic of the Brassicales order. Among them, aliphatic and indolic glucosinolates (IGs) are usually highly abundant in species from the Brassicaceae family. The exceptions this trend are species representing a subclade of the Camelineae tribe, including Capsella and Camelina genera, which have reduced capacity to produce and metabolize IGs. Our study addresses the contribution of specific glucosinolate-related myeloblastosis (MYB) transcription factors to this unprecedented backward evolution of IG biosynthesis. To this end, we performed phylogenomic and functional studies of respective MYB proteins. The obtained results revealed weakened conservation of glucosinolate-related MYB transcription factors, including loss of functional MYB34 protein, in the investigated species. We showed that the introduction of functional MYB34 from Arabidopsis thaliana partially restores IG biosynthesis in Capsella rubella, indicating that the loss of this transcription factor contributes to the backward evolution of this metabolic pathway. Finally, we performed an analysis of the impact of particular myb mutations on the feedback loop in IG biosynthesis, which drives auxin overproduction, metabolic dysregulation and strong growth retardation caused by mutations in IG biosynthetic genes. This uncovered the unique function of MYB34 among IG-related MYBs in this feedback regulation and consequently in IG conservation in Brassicaceae plants.