bluuebunny/crossref_metadata_2025_split huggingface dataset:
FABP1 expression in human tumors: a tissue microarray study on 17,071 tumors
Authors: Dum David , Ocokoljic Ana , Lennartz Maximilian , Hube-Magg Claudia , Reiswich Viktor , Höflmayer Doris , Jacobsen Frank , Bernreuther Christian , Lebok Patrick , Sauter Guido , Luebke Andreas M. , Burandt Eike , Marx Andreas H. , Simon Ronald , Clauditz Till S. , Minner Sarah , Menz Anne , Büscheck Franziska , Gorbokon Natalia , Steurer Stefan , Blessin Niclas C. , Krech Till 
Published: August 2022

Abstract Fatty acid–binding proteins (FABPs) play a pivotal role in the metabolism of fatty acids and are expressed in a tissue-specific manner. FABP1 is most abundantly expressed in the liver where it accounts for about 10% of the total cytosolic protein and is thought to have diagnostic utility. To comprehensively determine FABP1 expression in normal and neoplastic tissues, a tissue microarray containing 17,071 samples from 150 different tumor types and subtypes as well as 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. Among normal tissues, a strong FABP1 immunostaining was observed in hepatocytes, proximal tubuli of the kidney and epithelium of small intestine, appendix, and the colorectum. FABP1 positivity was found in 24 of 150 tumor categories, including 17 tumor categories with at least 1 strongly positive case. The highest FABP1 positivity rates were seen in colorectal adenomas (86%), in colorectal adenocarcinomas (71.1%), and in hepatocellular carcinomas (65.3%), followed by mucinous carcinoma of the ovary (34.6%), cholangiocarcinoma (21.6%), and various adenocarcinomas from the digestive tract (10–23%). Eleven additional entities had positivity rates between 0.2 and 6.5%. FABP1 staining was not seen in 169 primary adenocarcinomas of the lung. In colorectal cancer, reduced FABP1 expression was linked to poor-grade, right-sided tumor location, microsatellite instability (p < 0.0001 each), and absence of BRAF V600E mutations (p = 0.001), but unrelated to pT and pN status. FABP1 expression has considerably high tumor specificity. As FABP1 expression was virtually absent in adenocarcinomas of the lung, FABP1 immunohistochemistry might be particularly helpful to assist in the identification of metastatic colorectal or gastrointestinal adenocarcinoma to the lung.
General Lower Bounds and Improved Algorithms for Infinite–Domain CSPs
Authors: Jonsson Peter , Lagerkvist Victor 
Published: August 2022

AbstractWe study the fine-grained complexity of NP-complete, infinite-domain constraint satisfaction problems (CSPs) parameterised by a set of first-order definable relations (with equality). Such CSPs are of central importance since they form a subclass of any infinite-domain CSP parameterised by a set of first-order definable relations over a relational structure (possibly containing more than just equality). We prove that under the randomised exponential-time hypothesis it is not possible to find $$c > 1$$

c
>
1

such that a CSP over an arbitrary finite equality language is solvable in $$O(c^n)$$

O
(

c
n

)

time (n is the number of variables). Stronger lower bounds are possible for infinite equality languages where we rule out the existence of $$2^{o(n \log n)}$$

2

o
(
n
log
n
)

time algorithms; a lower bound which also extends to satisfiability modulo theories solving for an arbitrary background theory. Despite these lower bounds we prove that for each $$c > 1$$

c
>
1

there exists an NP-hard equality CSP solvable in $$O(c^n)$$

O
(

c
n

)

time. Lower bounds like these immediately ask for closely matching upper bounds, and we prove that a CSP over a finite equality language is always solvable in $$O(c^n)$$

O
(

c
n

)

time for a fixed c, and manage to extend this algorithm to the much broader class of CSPs where constraints are formed by first-order formulas over a unary structure.
Dosages of Swallowing Exercises Prescribed in Stroke Rehabilitation: A Medical Record Audit
Authors: Choy Jacinda , Pourkazemi Fereshteh , Anderson Caitlin , Bogaardt Hans 
Published: August 2022

AbstractThis study investigated how swallowing exercise dosage is recorded, and what swallowing exercise dosages are reported in a stroke rehabilitation setting. We additionally explored the relation between mean daily swallowing repetitions and likelihood of improvement in functional swallowing status and considered how swallowing exercise dosages in practice compared to evidence-based principles of neural plasticity and strength training. We audited medical records for 42 patients with post-stroke dysphagia admitted to an inpatient rehabilitation unit over 18 months. Data were collected on participant characteristics, swallowing exercises and dosages, and clinical outcomes. The relation between dosage and outcomes was investigated using logistic regression analysis. On average, patients were seen for a median of 2.4 swallowing intervention sessions per week (IQR: 1.7) over 21 days (IQR: 16) and received a median 44.5 swallowing exercise repetitions per session (IQR: 39.6). Results indicated variable reporting of swallowing exercise dosages. Frequency, intervention duration, exercise type, and number of repetitions were routinely recorded in medical records, while intensity, session length, content, and adherence to home exercise programs were not. Frequency of swallowing intervention was lower in practice compared to research studies, and swallowing exercises did not follow specificity or progressive resistance principles. Likelihood of improvement in swallowing status was partially explained by age (B = -.015, p = .007) but not by mean daily swallowing exercise repetitions. This study illustrates dosages of swallowing exercises used in clinical practice. Results highlight the need for improved consideration and reporting of dosage, and application of evidence-based principles to swallowing exercise dosages.
Pleomorphic Xanthoastrocytoma: a single institution retrospective analysis and a review of the literature
Authors: Detti Beatrice , Scoccianti Silvia , Maragna Virginia , Lucidi Sara , Ganovelli Michele , Teriaca Maria Ausilia , Caini Saverio , Desideri Isacco , Agresti Benedetta , Greto Daniela , Buccoliero Anna Maria , Puppa Alessandro Della , Sardi Iacopo , Livi Lorenzo 
Published: August 2022

Abstract
Background
Pleomorphic xanthoastrocytoma (PXA) is a rare low-grade brain tumor. To date, limited studies have analyzed factors affecting survival outcomes and defined the therapeutic strategy. The aim of this retrospective analysis was to investigate the clinicopathologic characteristics of PXA and identify factors associated with outcomes.

Methods
We retrospectively analyzed a cohort of 16 adult and children patients with PXA who underwent primary resection from 1997 to 2019, referred to our Radiation Oncology Unit and to Meyer’s Paediatric Hospital. We also reviewed the relevant literature.

Results
All patients underwent primary surgical resection; 10 patients received adjuvant radiation treatment course, ranging from DTF 54 to 64 Gy; 8 of them received, in addition, concurrent adjuvant chemotherapy; 6 patients underwent only radiological follow-up. After a median follow up was 60 months: median OS was 34.9 months (95% CI 30–218), 1-year OS 87%, 5-years OS 50%, 10-years OS 50%; median PFS 24.4 months (95% CI 13–156), 1-year PFS 80%, 5-years PFS 33%, 10-years PFS 33%. A chi-square test showed a significant association between OS and recurrent disease (p = 0.002) and with chemotherapy adjuvant treatment (p = 0.049). A borderline statistical significant association was instead recognized with BRAF mutation (p = 0.058).

Conclusions
Despite our analysis did not reveal a strong prognostic or predictive factor able to address pleomorphic xanthoastrocytoma management; however, in selected patients could be considered the addition of adjuvant radiation chemotherapy treatment after adequate neurosurgical primary resection. Furthermore, recurrent disease evidenced a detrimental impact on survival.
Spatio-temporal Prediction of the Malaria Transmission Risk in Minab District (Hormozgan Province, Southern Iran)
Authors: Salahi-Moghaddam Abdolreza , Turki Habibollah , Yeryan Masoud , Fuentes Màrius V. 
Published: August 2022

AbstractIntroductionMalaria is the most important parasitic disease in tropical and subtropical regions, with more than 240 million cases reported annually. In Iran, indigenous cases occur in its south-eastern region. The aim of this study is to assess the environmental risk of malaria transmission in an endemic area of southern Iran.MethodsThe study was carried out in Minab district (Hormozgan province, southern Iran), with the aim to assess the environmental risk of malaria, based on a spatio-temporal study, using Growing Degree Days (GDD)-based predictions, larval habitat ecology, MaxEnt spatial predictions and malaria transmission data.ResultsThe Gradient Model Risk index showed the highest malaria transmission risk period to be during January–April and October–December. The ecological conditions of water bodies of larval habitats of the four vector species (Anopheles culicifacies,A. dthali,A. fluviatilisandA. stephensi) were assessed, withA. stephensibeing the most prevalent and the most widely distributed species.ConclusionThese findings, together with the MaxEntAnophelespredictive distribution models, allowed identifying villages in danger of malaria transmission in Minab district. This spatio-temporal prediction of malaria transmission risk should be incorporated in the design of malaria control initiatives towards a local malaria early warning system. Moreover, the proposed transmission risk model can be extrapolated, at local scale, to other malaria endemic areas of tropical and subtropical regions.
Investigation of the Effectiveness of a Vertical Centrifugation System Coupled with an Inert Gas Dosing Device to Produce Extra Virgin Olive Oil
Authors: Angeloni Giulia , Spadi Agnese , Corti Ferdinando , Guerrini Lorenzo , Calamai Luca , Parenti Alessandro , Masella Piernicola 
Published: August 2022

AbstractRecent decades have seen the development of many effective and innovative technologies for extra virgin olive oil (EVOO) extraction. Various solutions have been proposed to remove dissolved oxygen from the oil. Given these issues, we have designed and developed a system that can be added to the centrifuges that are already used in the olive oil industry. The system reduces the oxidative impact through the release of a technical gas inside the separator, and consequently delays the onset of defects related to oxidation. The experiment tested different N2 flow rates, directly into the vertical centrifuge, and four levels of N2 were tested–a control level (no N2 injection); low (20 L/min), medium (40 L/min), and maximum (80 L/min)–in order to evaluate the effectiveness of this new technique on EVOO quality. This experiment demonstrates that the objectives have been achieved. The EVOO produced using our system had lower dissolved oxygen content with N2 injection, along with an enriched volatile fraction, and higher biophenol concentrations. The chemical analyses were confirmed by a sensory analysis, with an increase in fruity intensity and bitter taste.
What Do You Mean, ‘How Do I Feel about Ageing?’: Exploring Ageing Concepts on the Island of Gozo
Authors: LeMonde Julia 
Published: August 2022

AbstractMalta is experiencing a strong trend toward population ageing. In 2014, the government implemented an active ageing policy designed to address the perceived economic and social ramifications of an ageing population. In a commitment to break away from perceptions of ageing that equate with infirmity and decline, the policy underscores independence, productivity, and activity as meaningful goals in later life. Ethnographic data gathered from conversations with both Gozitan-born and English expatriate retirees (UK expats), investigated their perceptions of ageing. Tensions were revealed between the active ageing paradigm and core values and notions of personhood favoured by older adults. Respondents resisted identification with an ageing cohort, whilst valuing a safe and relaxed lifestyle and intergenerational social and familial relationships. These early findings destabilise the neoliberal and universalistic claims of the active ageing-paradigm, raising questions for further research.
Estimation of crop losses in Cajanus cajan (L.) Millsp. and Vigna radiata (L.) Wilczek caused by blister beetle, Mylabris pustulata Thunberg (Coleoptera: Meloidae)
Authors: Singh Gurjeet , Singh Ravinder , Singla Akanksha 
Published: August 2022

AbstractLosses caused byMylabris pustulataThunberg in pigeonpea and mungbean at various beetle densities were assessed under net house/caged and field conditions. The observations revealed that the blister beetle caused considerable crop losses to both the pigeonpea and mungbean crops as under net house conditions,M. pustulataThunberg at 200 beetles/cage caused the maximum reduction of 54.18, 20.15 and 64.88 per cent in pod setting, seed setting and grain yield in pigeonpea, respectively. Similarly, in mungbean,M. pustulataThunberg at 4 beetles/cage caused maximum reduction up to 67.14, 26.65 and 75.29 per cent in pod setting, seed setting and grain yield, respectively. However, under unprotected conditions, 46.77 and 35.90 per cent of yield losses were recorded in pigeonpea and mungbean, respectively as compared to 0% under protected conditions. Thus, justifying thatM. pustulataThunberg is a major threat to both pulse crops and needs to be managed efficiently to avoid the significant crop losses caused by it.
Surgical techniques in restoration lumbar lordosis: a biomechanical human cadaveric study
Authors: Ochtman A. E. A. , Bisschop A. , Bleys R. L. A. W. , Öner F. C. , van Gaalen S. M. 
Published: August 2022

Abstract
Purpose
Degenerative changes of the lumbar spine lead in general to decrease of lumbar lordosis (LL). This change affects the overall balance of the spine, and when surgery is deemed, necessary restoration of the LL is considered. How this restoration can be achieved is a matter of controversy. The main purpose of this cadaveric study was to investigate the different steps of common posterior surgical techniques to understand the contribution of each successive step in restoring LL.

Methods
Ten fresh-frozen human lumbar spine specimens were used to perform a sequential correction and instrumentation with a pedicle screw construct.

Results
The mean LL angle measured at L3–L4 in intact condition was 12.9°; after screw insertion and compression, this increased to 13.8° (+ 7%, p = 0.04), after bilateral facetectomy to 16.3° (+ 20%, p = 0.005), after discectomy and insertion of interbody cage to 18.0º (+ 9%, p = 0.012), after resection of the lamina and the processes spinosus to 19.8° (+ 10%, p = 0.017), and after resection of the anterior longitudinal ligament to 25.4° (+ 22%, p = 0.005).

Conclusions
Each step contributed statistically significant to restoration of segmental lordosis with bilateral facetectomy contributing the most in terms of percentage.

Level of Evidence
IV.
A service-oriented energy assessment system based on BPMN and machine learning
Authors: Yan Wei , Wang Xinyi , Gong Qingshan , Zhang Xumei , Zhang Hua , Jiang Zhigang 
Published: August 2022

AbstractIncreasing energy cost and environmental problems push forward research on energy saving and emission reduction strategy in the manufacturing industry. Energy assessment of machining, as the basis for energy saving and emission reduction, plays an irreplaceable role in engineering service and maintenance for manufacturing enterprises. Due to the complex energy nature and relationships between machine tools, machining parts, and machining processes, there is still a lack of practical energy evaluation methods and tools for manufacturing enterprises. To fill this gap, a serviced-oriented energy assessment system is designed and developed to assist managers in clarifying the energy consumption of machining in this paper. Firstly, the operational requirements of the serviced-oriented energy assessment system are analyzed from the perspective of enterprises. Then, based on the establishment of system architecture, three key technologies, namely data integration, process integration, and energy evaluation, are studied in this paper. In this section, the energy characteristics of machine tools and the energy relationships are studied through the working states of machine tools, machining features of parts and process activities of processes, and the relational database, BPMN 2.0 specification, and machine learning approach are employed to implement the above function respectively. Finally, a case study of machine tool center stand base machining in a manufacturing enterprise was applied to verify the effectiveness and practicality of the proposed approach and system.
Connecting children to nature through the integration of Indigenous Ecological Knowledge into Early Childhood Environmental Education
Authors: Acharibasam John Bosco , McVittie Janet 
Published: August 2022

AbstractIn this paper, we draw on the ontology and epistemology of the local Kasena ethnic group in Northern Ghana to explore Early Childhood Environmental Education. The study, taking place in Boania Primary School, drew on the concept of two-eyed seeing, where both western and Indigenous epistemologies and ontologies were taught. In this way, Indigenous Ecological Knowledge was integrated into the Early Childhood Environmental Education programme for the Kindergarten two classroom environmental studies topics. Two Indigenous Elders led the integration of local knowledge into environmental studies topics by visiting the school to teach the children through taking them outdoors for learning activities. After this, in-depth interviews were held with the teacher, Indigenous Elders, and nine children regarding their experiences. The purpose of the study was to explore how Indigenous Ecological Knowledges can help instil in children positive environmental attitudes and values, while also connecting them to nature and offering them a more relational understanding of human to nature relationships. Based on the Indigenous cultural framework of respect, reciprocity, and responsibility towards nature, the findings show that the integration of Indigenous Ecological Knowledge into environmental education has the potential to improve our relationships with the environment.
Is it good to be bad? An evolutionary analysis of the adaptive potential of psychopathic traits
Authors: Ene Ioana , Wong Keri Ka-Yee , Salali Gul Deniz 
Published: August 2022

AbstractAlthough psychopathy is widely conceptualised as a mental disorder, some researchers question the maladaptive nature of psychopathy, and argue that it might be advantageous from an evolutionary point of view. According to this view, psychopathy can be seen as an evolutionary adaptative strategy that relies on deception and manipulation to gain short-term reproductive benefits. Psychopathy is also identified as a fast life strategy in response to early life stress and an adaptation to harsh environments. This paper investigates the evidence that psychopathic traits are adaptive, while also addressing the limitations of current evolutionary models of psychopathy based on frequency-dependent selection and life history theory. We review recent studies on the fitness correlates of psychopathy and find that psychopathic traits present potential adaptive trade-offs between fertility and mortality, and offspring quantity and quality. On a proximate level, individual differences in stress reactivity and environmental risk factors in early development predispose to psychopathy through gene–environment interactions. We propose that environmental, developmental, social and cultural factors can mediate the relationship between psychopathic traits and fitness and therefore should be considered to make accurate predictions on the adaptive potential of psychopathy. We end by outlining gaps in the literature and making recommendations for future evolutionary research on psychopathy.
THE ABSOLUTE -MEASURE OF TOTALLY POSITIVE ALGEBRAIC INTEGERS
Authors: WANG CONG , PANG XIAOJUAN , WU QIANG 
Published: August 2022

AbstractLet
$\alpha $
be a totally positive algebraic integer of degree d, with conjugates
$\alpha _1=\alpha , \alpha _2, \ldots , \alpha _d$
. The absolute
$S_k$
-measure of
$\alpha $
is defined by
$s_k(\alpha )= d^{-1} \sum _{i=1}^{d}\alpha _i^k$
. We compute the lower bounds
$\upsilon _k$
of
$s_k(\alpha )$
for each integer in the range
$2\leq k \leq 15$
and give a conjecture on the results for integers
$k>15$
. Then we derive the lower bounds of
$s_k(\alpha )$
for all real numbers
$k>2$
. Our computation is based on an improvement in the application of the LLL algorithm and analysis of the polynomials in the explicit auxiliary functions.
Complications after cochlear implantation in adult patients: a retrospective study
Authors: Dalgic A , Bozkurt E Basaran , Aliyeva A , Görgülü E , Ceylan M E , Edizer D T , Olgun L 
Published: August 2022

AbstractObjectiveTo examine the complication rate in adult patients during and after cochlear implantation.MethodsA retrospective chart review was conducted of patients who had undergone cochlear implantation at a tertiary referral centre between 2009 and 2018. All complications and their treatments were categorised as either minor or major, as well as intra- or post-operative.ResultsThe records of 392 patients with 395 implants were reviewed. The mean follow-up period was 89 ± 65.5 months (range, 6–408 months). The mean age of patients was 46 ± 15.2 years (range, 19–84 years). Sixty-two patients (16 per cent) had minor complications and 31 (8 per cent) had major complications.ConclusionAlthough cochlear implantation has the potential for significant intra- and post-operative complications, the actual complication rate is relatively low, and it can therefore be considered a safe procedure.
Randomized Controlled Trial of Group Exercise Intervention for Fall Risk Factors Reduction in Nursing Home Residents
Authors: Pepera Garyfallia , Krinta Katerina , Mpea Christina , Antoniou Varsamo , Peristeropoulos Argirios , Dimitriadis Zacharias 
Published: August 2022

AbstractObjectiveThe aim of this study was to assess the effectiveness of a multidimensional exercise intervention on improving fall risk deterrent factors, such as overall strength and flexibility in nursing home residents.MethodsA multi-centre, randomized controlled trial was finally utilized in 40 older adults (>65 years) who were randomly allocated to the intervention or the control group (20 subjects in each). The intervention group attended an exercise program twice a week for eight weeks, to improve functional mobility. The control group did not receive any intervention. Measurements before and after intervention included the Hand Grip Strength (HGS) testing, the Sit-to-Stand test (SST), the Back Scratch Test (BST), and the Sit-and-Reach test (SRT).ResultsMANOVA revealed significant time effects, V = 0.336, F(6, 33) = 2.78, p = 0.027, partial η2 = 0.336; group effects, V = 0.599, F(6, 33) = 8.22, p < 0.001, partial η2 = 0.599; and group*time interaction, V = 0.908, F(6, 33) = 54.52, p < 0.001, partial η2 = 0.908. A subsequent univariate analysis did not reveal a significant time effect for any variable (p > 0.05). Significant group effects were observed only for SRT (p < 0.05). Significant group*time interactions were observed for all the examined variables (p < 0.05). Dependent t-tests showed that the older adults in the exercise group were significantly improved in all the examined parameters (p < 0.05). Except for SRT (p > 0.05), all the other parameters significantly deteriorated in the control group (p < 0.05).ConclusionsSignificant improvements were demonstrated in strength and flexibility among nursing home residents following an eight-week group exercise training program.