bluuebunny/crossref_metadata_2025_split huggingface dataset:
Host-dependent clinical risk factors and inflammatory cytokine levels as predictive markers of respiratory syncytial virus bronchiolitis in infants
Authors: Narożna Beata , Langwiński Wojciech , Komasińska Paulina , Szczepankiewicz Aleksandra , Bręborowicz Anna , Szczawińska-Popłonyk Aleksandra 
Published: May 2022

Abstract
Purpose: Respiratory syncytial virus (RSV) is responsible for most cases of acute bronchiolitis in infants that require hospitalization. The infection is modulated by the local inflammatory response of the immune system via the production of pro-inflammatory cytokines. This study sought to determine the differences in the local immune response between children with RSV-positive and RSV-negative bronchiolitis. We also analyzed correlations between clinical parameters and molecular markers to define useful biomarkers of RSV infection.Methods: Children hospitalized due to acute bronchiolitis were recruited during three consecutive epidemiological seasons and divided into RSV-positive (n=42) and RSV-negative (n=81) groups. Clinical and demographic data were collected. RNA was isolated from nasopharyngeal aspirates and transcribed into cDNA. Gene expression of selected cytokines (IL-1β, IL-4, IL-8, IL-10, IL-12, IFN-γ and TNF-α) was analyzed via quantitative real-time PCR. Statistical analysis was performed in Statistica v.13.Results: RSV-positive patients were longer hospitalized (P=0.005) and required longer supplemental oxygen therapy (P<0.0001). Moreover, they had lower admission weight (P=0.017), lower partial pressure of oxygen (P=0.02) and higher CRP levels (P=0.02). Significantly higher rates of cesarean delivery (P=0.04) and familial atopy (P=0.006) were also observed in patients with an RSV infection. Comparison analysis revealed that IL-10, IL-12 and IFN-γ gene expression was significantly lower in patients with RSV than in patients without RSV (P=0.020, P=0.039 and P =0.003, respectively). In contrast, the expression of other cytokines did not differ significantly between the studied groups. Logistic regression analysis indicated that the expression of Th1 and Th2 cytokines, combined with clinical risk factors, significantly improved discrimination accuracy between RSV-positive and RSV-negative patients. Conclusions: Our results show that the expression of several cytokines significantly differs between children with RSV-positive and RSV-negative bronchiolitis, suggesting their involvement in the pathomechanism of RSV infection. The gene expression of IL-10, IL-12 and IFN-γ cytokines, lower admission weight, cesarean delivery and familial atopy could become clinical and diagnostic markers that facilitate the discrimination between RSV and non-RSV aetiology of bronchiolitis.
Long-term outcomes of cryoablation for biopsy-proven T1 stage renal cell carcinoma
Authors: Song Shangqing , Yang Qing , Gu Chengyuan , Yu Guopeng , Hua Bao , Gu Xin , Wang Linhui , Wang Zhong , Shi Guohai , Xu Bin 
Published: May 2022

Abstract
Objective To summarize our clinical experience of cryoablation in renal cell carcinoma (RCC) of Chinese population and to evaluate the long-term outcomes of laparoendoscopic single-site (LESS) cryoablation (LCA) as well as percutaneous CT-guided cryoablation (PCA) for biopsy-proven T1a and T1b RCC.Methods This was a multi-center, retrospective study investigating T1 stage RCC patients from 2011 to 2021. The patients were treated by LCA or PCA according to individual situation. Overall survival (OS), cancer-related survival (CSS) and progression-free survival (PFS) were evaluated for oncological outcomes and kidney function, complications, hospital stay were used to estimate technical outcomes. Results 163 consecutive patients were included. Among them, 59 cases were treated by LCA and PCA was performed in 104 cases. All operations were processed successfully. Mean diameter of the mass was (2.9±1.4) cm, median blood volume was 45ml (10~200 ml). The mean operation time was (84.0±24.5) min. The median postoperative hospital stay was 3 days (1~6 days). Compared with LCA, procedure time of PCA was shortened, the volume of bleeding was reduced, and the hospital stay was decreased. The overall adverse events rate was 9.8% (16/163). The mean pre-operative and post-operative eGFR of LCA were 77.6±15.3 ml/min and 75.6±17.4 ml/min, respectively. Analogously, the values of PCA were 78.7±12.9 ml/min and 76.7±14.3 ml/min. Mean follow-up time was 64.2 ± 30.2 months (range, 7-127 months). Local recurrence was observed in 13 patients (8.0%), 4 (6.8%) cases of LCA and 9 (8.7%) cases of PCA. PFS at 5 and 10 years were 95.5% and 69.2% for LCA and 96.7% and 62.8% for PCA. In total, 26 patients (16.0%) (11 patients from LCA and 15 from PCA) died throughout the follow-up period. OS at 5 and 10 years were 93.8% and 31.4% for LCA, and 97.4% and 52.7% for PCA. 6 patients (3.7%) (3 cases from LCA and 3 from PCA) died of metastatic RCC. CCS for LCA were 98.0% and 82.8% at 5 and 10 years, while the data were 100% and 86.4% for PCA. Conclusion LCA and PCA for T1 stage RCC provides satisfactory long-term oncological and renal function preservation outcomes, with acceptable complication rates.
Additive influence of extreme events and local stressors on coral diversity in the Mesoamerican Reef during the last decade
Authors: Muñiz-Castillo Aarón Israel , McField Melanie , González Jesús Ernesto Arias 
Published: May 2022

Abstract
Losing coral diversity is one of the most important consequences of coral reefs' ongoing degradation. Alternate: As the planet enters its sixth global extinction event, the loss of biodiversity due to coral reef degradation becomes of paramount importance. However, the loss of coral species diversity and its relationship to multiple global and local stressors remains largely untested on different temporal or spatial scales. This study evaluates the change in coral species diversity and its relationship to different stressors and habitat characteristics, using ecological data from 73 sites in the Mesoamerican Reef (MAR) and a variety of potential explanatory variables derived from remote sensing. We found a loss of coral diversity in the period analyzed, from 2010 to 2018. In addition to a decrease in diversity, there was also a considerable change in coral assemblages. The coral reefs that presented a greater loss of species were those with higher initial diversity and those with a higher number of annual bleaching risk events. Surprisingly, coral reefs exposed to hurricanes and turbidity with intermediate magnitude did not experience the same loss in diversity; some reefs even experience an increased diversity in this timeframe. The rate of increase in macroalgal cover was related to the decrease in coral diversity. Our results highlight the need to protect reefs with high diversity and constantly exposed to high heat stress events. These reefs should be considered sites of relevance in future conservation plans in the current context of global environmental change.
A Prospective Evaluation of Arrhythmias in a Large Tertiary Neonatal Intensive Care Unit
Authors: Chaudhry-Waterman Nadia , Nashed Lydia , Chidester Rachel , Nalewanski Alexandra , Bastawrous David , Busch Hayley , Jeong Hyungjoo , Baker Robin , Donnelly Kathleen , Cohen Mitchell 
Published: May 2022

Abstract
Introduction:
Arrhythmias in the neonatal period are common and can be classified as bradyarhythmias and tachyarrhythmias and as benign or non-benign. Neonatal arrhythmias are further differentiated between those with abnormalities in generation (non-sinus) and those with abnormalities in propagation. Because the neonatal myocardium is immature and operates at the peak of the Starling curve, significant changes in heart rate can result in a decline in cardiac output and compromise end-organ perfusion. This is especially true for premature neonates, those critically ill, or those with concomitant congenital heart disease. While sustained arrhythmias are frequently witnessed and recorded in tertiary neonatal intensive care units (NICU) very little data exists on the observance of non-sustained brady or tachyarrhythmias in this cohort. No prospective study has been performed on all neonates admitted to a large tertiary NICU throughout their entire stay. The purpose of this study was to prospectively evaluate the prevalence and type of arrhythmias in a large NICU population from admission to discharge.
Methods:
All neonates admitted to the NICU at Inova Children’s Hospital at Inova Fairfax Medical Campus between January 1, 2021 and April 1, 2021 were prospectively evaluated from admission to hospital discharge via continuous bedside monitoring reviewed every 24 hours. Concerning telemetry strips were reviewed by two team members as well as the senior electrophysiologist.
Results:
Two-hundred and one neonates (mean gestational age = 344/7 weeks’) were enrolled in the study. Admission length ranged from 1 to 195 days (total of 5624 patient days, median 16 days). Overall, 68% (N = 137) of admissions had one or more arrhythmias, the most common of which was sinus tachycardia (65%, N = 130), followed by sinus bradycardia (30%, N = 60). Clinically relevant arrhythmias were diagnosed in 6.5% of neonates. During the study period there were four deaths, none of which were directly attributable to a primary arrhythmia.
Conclusion:
Approximately 68% of neonates exhibited at least one arrhythmia. Although the vast majority of these arrhythmias were benign, clinically relevant arrhythmias were observed in 6.5%. Patients admitted to the NICU appear to have a relatively high burden of benign arrhythmias, but a relatively low burden of pathologic arrhythmias.
Divergent subgenome evolution in the allotetraploid frog Xenopus calcaratus
Authors: Knytl Martin , Fornaini Nicola R. , Bergelová Barbora , Gvoždík Václav , Černohorská Halina , Kubíčková Svatava , Fokam Eric B. , Evans Ben J. , Krylov Vladimír 
Published: May 2022

Abstract
Allopolyploid genomes are divided into compartments called subgenomesthat are derived from lower ploidy ancestors. In African clawed frogsof the subgenus Xenopus (genus Xenopus), allotetraploid species havetwo subgenomes (L and S) with morphologically distinct homoeol-ogous chromosomes. In allotetraploid species of the sister subgenusSilurana, independently evolved subgenomes also exist, but their cytogenetics have not been investigated in detail. We used an allotetraploid species in Silurana—Xenopus calcaratus—to explore evolutionary dynamics of chromosome morphology and rearrangements. We find that the subgenomes of X. calcaratus have distinctive characteristics, with a more conserved a-subgenome resembling the closelyrelated genome of the diploid species X. tropicalis, and a more rapidlyevolving b-subgenome having more pronounced changes in chromosome structure, including diverged heterochromatic blocks, repetitivesequences, and deletion of a nucleolar secondary constriction. Basedon these cytogenetic differences, we propose a chromosome nomenclature for X. calcaratus that may apply to other allotetraploids insubgenus Silurana, depending on as yet unresolved details of theirevolutionary origins. These findings highlight the potential for large-scale asymmetry in subgenome evolution following allopolyploidization.
Double-norm constrained dictionary learning image denoising algorithm
Authors: Ji Changpeng , He Lina , Dai Wei 
Published: May 2022

Abstract
An image denoising method combining fuzzy C-means structure clustering and sparse coding with double-norm constraints is proposed based on the features of a self-adaptive dictionary that can better use the image’s information. First, the fuzzy C-means structure clustering method is used to perform structural clustering on the original image after divided into small block; Second, the principal component analysis method is used to train the block image after the structure clustering into a super-complete adaptive sparse dictionary,then applied to image denoising through sparse coding; Finally, the denoising image is reconstructed by non-local self-similarity. Using the Set12 dataset and OASIS database, the experiments were performed under image with Gaussian white noise or pink noise. The experiments’ results show that the algorithm reduces the noise of noisy images and retains the edge and the texture information of the original image; Compared with KSVD, ISKR, EPLL, and other denoising algorithms, the proposed algorithm has achieved good results in visual similarity and peak signal-to-noise ratio.
How Alcohol and/or Tobacco Use and Raised Glycemia are Associated with Oral Hygiene Practices among Burkinabè Adults: Evidence from the first National Non-communicable Disease Risk Factors Survey
Authors: Diendéré Jeoffray , Bosu William Kofi , Ouédraogo Wend-Lassida Richard , Ouattara Seydou , Konsem Tarcissus , Zeba Augustin Nawidimbasba , Kouanda Séni 
Published: May 2022

Abstract
Socio-demographic correlates with oral hygiene practices are commonly investigated. The present study aimed to determine whether alcohol and/or tobacco use and hyperglycemia were associated with oral hygiene practices among Burkinabè adults. This descriptive, cross-sectional study included 4550 adults selected through multistage cluster sampling performed during the first WHO STEPS survey conducted in 2013 in Burkina Faso. The practices we considered were the frequencies of tooth cleaning, the fluoridated toothpaste use and the dentist visit within the past-six months. We collected data on self-reported alcohol and tobacco use and measured fasting blood glucose (FBG). About 82.8% of respondent reported they cleaned their teeth at least once a day, 31.5% cleaned them at least twice a day, 25.4% used fluoridated toothpaste, 2.2% had visited a dentist in the past six months, 38.8% used either alcohol or tobacco and 8.4% had raised FBG. After adjusting for socio-demographic factors, alcohol and/or tobacco use was an unfavorable factor for tooth cleaning at least once a day [aOR = 0.7 (0.6–0.8) p < 0.001], or at least twice a day [aOR = 0.6 (0.5–0.7) p < 0.001]. Moreover, raised FBG was negatively associated with cleaning tooth at least twice a day [aOR = 0.7 (0.5–0.9) p < 0.01] or the use of fluoridated toothpaste [aOR = 0.7 (0.6–0.9) p < 0.05]. Oral health education in addition to cardiovascular risk factor reduction should be efficiently integrated in the behavioral lifestyle interventions’ strategies for the non-communicable diseases’ prevention.
Efficient Maximum Power Point Tracking in Grid Connected Switched Reluctance Generator in Wind Energy Conversion System: An EMATSO Approach
Authors: Sridha S , V Vasan Prabhu , Velmurugan P 
Published: May 2022

Abstract
In this manuscript presents an efficient hybrid approach for fast and efficient MPPT in WECS. The system has MPPT based control of Switched Reluctance Generator (SRG) containing a hybrid Meta-heuristic algorithm. The hybrid proposed method is joint implementation of Mayfly Algorithm (MA) and Transient Search Optimization (TSO) named as enhanced MATSO (EMATSO) method. The reduction of speed error is the main aim of the proposed method. Depend on direct variation and quadrature current parameters the MA method is proposed to stimulate the maximum gain parameters of proportional integral (PI) controller with lowest error function. Here, the MA search behavior is enhanced using the efficient TSO algorithm. Based on speed variation of generator using MPPT method and loss reduction method the direct axis set point and the quadrature axis current parameters of WECS are developed. The proposed EMATSO method has enhanced the efficiency of the WECS with this proper control. At last, the proposed model is updated on MATLAB/Simulink platform and performance is compared to other methods like GA, ALO, TSA and MA
Revision of Geostiba of the West Palaearctic region. XXVIII. New species and records from the Georgian Caucasus (Coleoptera: Staphylinidae: Aleocharinae)
Authors: Assing Volker 
Published: May 2022

A study of 485 specimens of Geostiba Thomson, 1858, 482 of which were collected during three field trips to West Georgia conducted in 2021, yielded eleven species, two of which are described and illustrated: Geostiba (Sibiota) brevifistula spec. nov. (Georgia: Kvemo Svaneti) and G. (S.) egrisica spec. nov. (Georgia: Samegrelo-Zemo Svaneti). Both species belong to the G. bituberculata group. Geostiba (Geostiba) sororcula Assing, 2001, a species previously known only from Northeast Turkey and Armenia, is reported from Georgia for the first time. The distributions of five species are mapped. The Geostiba fauna of the Caucasus region sensu lato is now represented by a total of 50 species, 30 of which belong to the subgenus Sibiota Casey, 1906.
Taxonomic acts
Geostiba brevifistula spec. nov. – urn:lsid:zoobank.org:act:C9599E3F-3AB0-4C10-980C-862F374E3EE8 Geostiba egrisica spec. nov. – urn:lsid:zoobank.org:act:267A9CC9-F7A1-4CED-8594-1CE8CF16C0E9
Formas discursivas contemporáneas de juventud y sus límites: la construcción mediática de jóvenes de las clases subalternas en Córdoba, Argentina (2014)
Authors: Espoz Dalmasso María Belén , Boito María Eugenia 
Published: May 2022

El artículo tiene como objetivo señalar las tendencias a partir de las cuales la ‘juventud’ se configura en una forma particular de vivencia en las ciudades del sur global. Ello a partir de la identificación de los marcos de interpretación que construyen los medios de comunicación masiva en torno a sus valores y sus límites (los de los jóvenes de los sectores populares de la ciudad de Córdoba, Argentina). Para la descripción y análisis seleccionamos un corpus gráfico, de dos periódicos (La Voz del Interior y La mañana de Córdoba en su versión digital) y la metodología seleccionada el análisis del discurso, desde los aportes de Bajtín y Voloshinov, y algunos conceptos fundamentales de la crítica ideológica.
ECONOMIA SOLIDÁRIA NO BRASIL: Elementos de uma dialética e dialógica do fracasso – causas possíveis, correções necessárias, desafios inevitáveis
Authors: Oliveira Edson Marques 
Published: May 2022

Realiza-se um estudo de caso sobre economia solidária entre Brasil e Portugal,tendo como ponto de partida uma experiência prática de incubação de tecnologias sociais e empreendimentos, na Unioeste, Paraná Brasil e Universidade de Coimbra, em Portugal. Ao estudar as causas do fracasso, identificou-se princípio e conceito da dialética e da dialógica do fracasso, e considerou-se esse momento como oportunidade de aprendizagem e não de derrota. Os principais resultados apontam que os princípios de autogestão,cooperação e solidariedade são afetados pelos processos de individualizaçãogerados pela lógica do hiperconsumo, desequilíbrio entre competição ecooperação, distorção da ética da autenticidade, processo acentuado de satisfações pessoais, acima das realizações e necessidadescoletivas, os quais comprometem a cooperação e a solidariedade numaperspectiva emancipatória, gerando assim um paradoxo da cooperação e seuenfraquecimento e fragilizando o sentido de solidariedade no contexto contraditório da sociedade do consumo, impondo a necessidades de correções necessárias e confrontos inevitáveis.
A AMÉRICA COMEÇA NOS PIRINEUS: As relações Ibéricas na “raia” portuguesa e a fronteira da Europa com a América Latina
Authors: Moura Filho José Luiz 
Published: May 2022

Discute-se o arranjo institucional denominado Euroregião Galiza/Norte de Portugal, para contribuir no processo de integração em curso na América do Sul – MERCOSUL - tomando-se por parâmetro a atual organização política, econômica e socio-espacial de aglomerados transfronteiriços como Chuí/Chuy, na fronteira do Brasil com o Uruguai. Teoricamente centrar-se-á nas categorias “cooperação sem governo (central)” e “complementar para competir”, que pautam a cooperaçãotransfronteiriça naquela porção da UE, sem descuidar de conceitos caros ao ordenamento territorial como “região”, “fronteira” e “cultura”, historicamente relativos e fugazes em momentos como oque vivem os Estados-Nação, na presença de fenômenos como a globalização. A investigação da ocorrência de metodologia de análise socio-espacial semelhante àquela consistente na dialética entre oscircuitos superior e inferior da economia urbana (Milton Santos, 2004), flagrante no espaço paradigmático através da presença de free shop e vendedores ambulantes, poderá contribuir para a superação dodilema “integração regional x concorrência local”. Parte-se da concepção de uma “cultura de fronteira” como elemento de integração das realidades territoriais envolvidas, sobretudo quando articulamEstados Nacionais em blocos, como o MERCOSUL e a UE. Naquele caso observa-se que a ação estatal voltada ao desenvolvimento urbano responde a pressões do circuito superior, aprofundando assimetrias nos espaços urbanos compartilhados. A complementaridade entre os circuitos da economia urbana nestas cidades aparece como solução que, somada à ação do Estado para dispersão no território de equipamentos sociais, possibilita a (re)apropriação, pelas populações locais, dos espaços tomados pelo econômico. Isso acaba por conformar uma nova identidade, portadora de valores que estão na base de uma comunidade, objetivo maior a ser perseguido por projetos de integração e desenvolvimento regional. A relação com a UE, então, se dá em razão da similaridade de condições jurídico-políticas (poder local/tradição municipalista) e de indicadores socioeconômicos, restando, pois, analisar os arranjos político-institucionais indispensáveis.
A tradição do Festival de Caretos de Salsas ou os relatos da mudança social
Authors: Lafita Savina 
Published: May 2022

Numa perspectiva que permite analisar a festa dos Caretos de Salsas como fonte de discursos e práticas de género, este trabalho, que situa a festa num processo mais amplo de revitalização e patrimonializaçãodas festas de inverno no nordeste de Portugal, pretende refletir sobre a maneira como a mudança semântica que a performance sofreu interpela as memórias individuais colaborando no processo de mitificação da tradição.
Electrochemical Aptasensing for Lifestyle and Chronic Disease Management
Authors: Upasham Sayali , Pali Madhavi , Jagannath Badrinath , Lin Kai-Chun , Prasad Shalini 
Published: May 2022

Abstract:
Over the past decade, researchers have investigated electrochemical sensing
for the purpose of fabricating wearable point-of-use platforms. These wearable platforms
have the ability to non-invasively track biomarkers that are clinically relevant and provide
a comprehensive evaluation of the user’s health. Due to many significant operational
advantages, aptamer-based sensing is gaining traction.Aptamer-based sensors have
properties like long-term stability, resistance to denaturation, and high sensitivity. Using
electrochemical sensing with aptamer-based biorecognition is advantageous because it
provides significant benefits like lower detection limits, a wider range of operations, and,
most importantly, the ability to detect using a label-free approach. This paper provides an
outlook into the current state of electrochemical aptasensing. This review looks into the
significance of the detection of biomarkers like glucose, cortisol etc., for the purpose of
lifestyle and chronic disease monitoring. Moreover, this review will also provide a comprehensive
evaluation of the current challenges and prospects in this field.