bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tandem occlusions involving the internal carotid and anterior cerebral arteries—A rare form of stroke: Results from the multicenter EVATRISP collaboration study
Authors: Filioglo Andrei , Simaan Naaem , Honig Asaf , Heldner Mirjam , Pezzini Alessandro , Martinez-Majander Nicolas , Padjen Visnja , Baumgartner Philipp , Papanagiotou Panagiotis , Salerno Alexander , Nolte Christian , Nordanstig Annika , Engelter Stefan , Zini Andrea , Zedde Marialuisa , Marto João Pedro , Arnold Marcel , Magoni Mauro , Gensicke Henrik , Cohen Jose , Leker Ronen 
Published: December 2022

BackgroundPatients with stroke secondary to isolated anterior cerebral artery (ACA) occlusions have poor outcomes. Whether tandem occlusions (TO) of the extracranial internal carotid (ICA) and the ACA carry even worse outcomes that remain unknown.MethodsPatients with TO involving ICA and ACA occlusions were identified from 14 participating centers from the EndoVascular treatment And ThRombolysis in Ischemic Stroke Patients (EVATRISP) project which is a multicenter, observational, cohort study with prospective accrual of data followed by retrospective data analysis. Patients with isolated ACA stroke served as controls.ResultsIncluded were 92 patients with isolated ACA and 16 patients with ICA-ACA TO stroke. On univariate analyses, patients with TO had more severe strokes on admission [median NIHSS (IQR) 13.5 (9–21) vs. 8 (5–12), p = 0.003] and were more often treated with thrombectomy (81 vs. 40%, p = 0.002). Mortality rates were higher among TO patients (31 vs. 11%, p = 0.03). Rates of favorable functional outcomes were numerically lower among TO patients (38 vs. 60%) but the difference was not statistically significant (p = 0.09). On multivariate analyses, the presence of TO did not modify the chances for favorable outcomes.ConclusionTO stroke with ICA and isolated ACA involvement is rare and results in more severe initial neurological deficits and higher mortality compared to those seen in patients with isolated ACA stroke.
Causal association between adiponectin and the risk of Alzheimer's disease: A Mendelian randomization study
Authors: Jin Tianyu , Huang Wei , Cao Fangzheng , Yu Xinyue , Ying Zhenhua , Guo Shunyuan , Cheng Yifan , Xu Chao 
Published: December 2022

BackgroundNumerous observational studies have revealed that circulating adiponectin (ADPN) is associated with Alzheimer's disease (AD) risk. However, the causality remains unknown. We aimed to assess the causality of circulating ADPN on AD risk using Mendelian randomization (MR).MethodsFourteen single nucleotide polymorphisms (SNPs) significantly associated with ADPN were selected from publicly available genetic abstract data. We applied these SNPs to two recent large-scale genome-wide association studies (GWAS) of AD, one from the FinnGen consortium and the other from a large meta-analysis. The inverse variance weighted method, MR–Egger method, the weighted median method, the Cochran Q statistic, the MR-Pleiotropy Residual Sum and Outlier methods, and the leave-one-out analysis were applied for MR analyses.ResultsIn MR analysis, no significant genetic association was found between plasma ADPN levels and AD risk by analyzing the FinnGen consortium GWAS database in the inverse variance weighted method [odds ratio (OR): 0.874, 95% confidence interval (CI): 0.701–1.089, p = 0.230], MR–Egger (OR: 0.944, 95% CI: 0.692–1.288, p = 0.721), and weighted median method (OR: 0.900, 95% CI: 0.678–1.194, p = 0.449). Additionally, the same analysis was conducted for the meta-analysis database, and we found no significant association (OR: 1.000, 95% CI: 0.999–1.001, p = 0.683).ConclusionOur findings reveal no significant causal association between circulating ADPN and AD risk.
Dietary patterns, nutritional status, and mortality risks among the elderly
Authors: Liu Zhen , Xu Di , Xu Wen-xiu , Fei Yin-jiao , Wang Dan-dan , Deng Fei , Tang Jin-hai 
Published: December 2022

IntroductionWhile most epidemiological studies have focused on the effects of individual dietary patterns and nutritional status on health, the relationships between the combinations of these factors and patient prognosis requires further investigation.ObjectiveThis study explored mortality risk in individuals with different combinations of dietary patterns or nutritional status.MethodsUnsupervised K-means clustering was used to classify populations. The analyses included Cox proportional risk and competing risk models.ResultsAfter considering a complex sampling design, the results showed that among 12,724 participants aged &gt;60 years, 6.99% died from cancer and 10.47% from cardiovascular and cerebrovascular disease (CCVD). After correcting for participant baseline information and chronic conditions, the geriatric nutritional risk index and healthy eating index (HEI) were negatively associated with the risk of all-cause and cause-specific mortality. The opposite was true for the dietary inflammatory index (DII). After sorting the population three clusters based on study scores showed higher risks of all-cause mortality and cancer-related death in Cluster 2 and 3.DiscussionThese results suggest that different nutritional status and dietary patterns are associated with the risk of all-cause mortality and death from cancer and CCVD in people aged &gt;60 years in the United States. Dietary patterns with high HEI and low DII were beneficial to health, whereas nutritional status needs to be maintained at a level that is not too low.
A frameshift mutation of TMPRSS3 in a Chinese family with non-syndromic hearing loss
Authors: Liang Jingwen , Yu Zhuoheng , Wang Zhangxing , Chen Jianxia , Liu Yihuan , Yin Zhaoqing , Xu Ruihuan 
Published: December 2022

BackgroundDeafness is the most common sensory defect in humans worldwide. Approximately 50% of cases are attributed to genetic factors, and about 70% are non-syndromic hearing loss (NSHL).ObjectivesTo identify clinically relevant gene variants associated with NSHL in a Chinese family using trio-based whole-exome sequencing (WES).Materials and methodsWES was performed on the 18-month-old female proband, and her parents. Gene variants specific to the family were identified by bioinformatics analysis and evaluated for their relevance to NSHL. We verified the novel variant in this family by the next-generation sequencing.In order to elucidate the frameshift mutation of TMPRSS3 in a Chinese family, we used the Mass spectrometry to detect the gene from 1,010 healthy subjects.ResultsWe identified a novel homozygous deletion (c.51delA) in exon 2 of the type II transmembrane serine protease 3 gene TMPRSS3, which resulted in a frameshift mutation just before the protein transmembrane domain (p.Q17fs). The deletion was present in the proband and her father, but not in her mother and the healthy controls. We also found mutations with potential relevance to hearing loss in DCAF17, which encodes a protein of unknown function (c. T555A: p.H185Q), and ZNF276, which encodes zinc finger protein 276 (c.1350–2A &gt; G).Conclusions and significanceWe shown a novel frameshift mutation in TMPRSS3 associated with autosomal recessive NSHL in a Han Chinese family.
Effect of educational brochure compared with video on disease-related knowledge in patients with juvenile idiopathic arthritis: A randomized controlled trial
Authors: Sunthornsup Waraporn , Vilaiyuk Soamarat , Soponkanaporn Sirisucha 
Published: December 2022

IntroductionPatient education plays an important role in the management of chronic diseases such as juvenile idiopathic arthritis (JIA). This study compared the effectiveness of a brochure and a video regarding JIA-related knowledge immediately after the intervention, and at 4 weeks post-intervention.MethodsA prospective randomized controlled trial was conducted. Patients with JIA or parents were randomized to receive education from either a brochure (n = 50) or a video (n = 50) at the clinic. Participants answered questionnaires about disease-specific knowledge before the intervention (T0), immediately after the intervention (T1), and at follow-up 4 weeks later (T2). The questionnaire comprised 15 multiple-choice questions. Final scores ranged from 0 to 15, and were scaled from 0% to 100% to calculate the percentage of knowledge scores. Ninety participants completed the questionnaire at T2 (42 in the brochure and 48 in the video group).ResultsThe mean percentage of knowledge scores at T0 was not significantly different between the brochure group and the video group. At T1, the mean percentage of knowledge scores was significantly higher in the video group compared with the brochure group (86.7 ± 12.9% vs. 76.0 ± 21.4%, p = 0.003). Among parents with an educational level below secondary school, the mean percentage of knowledge scores at T1 was significantly higher in the video group compared with the brochure group (83.5 ± 14.4% vs. 69.1 ± 23.2%, p = 0.006). Participants in both groups had significantly higher mean percentage of knowledge scores at T2 compared with T0 (72.7 ± 20.3% vs. 51.1 ± 24.7%, p &lt; 0.001 in the brochure group and 78.3 ± 15.7% vs. 56.1 ± 21.9%, p &lt; 0.001 in the video group). There was no significant difference in the mean percentage of total score change between T2 and T1 between the brochure and video groups (−4.7 ± 13.3% vs. −8.5 ± 11.0%, p = 0.152).ConclusionThe video was more effective for improving disease-related knowledge immediately post-intervention, particularly in participants with limited education. Although both educational tools had lasting effects on knowledge, the retention rate declined at 4 weeks after both interventions.Trial registrationThai Clinical Trials Registry (TCTR)20200310004, retrospectively registered since 06/03/2020
Safety of oral nemonoxacin: A systematic review of clinical trials and postmarketing surveillance
Authors: Yuan Jinyi , Zhang Xiaoping , Chen Jing , Zhang Yueyuan , Zhu Fengjia , Huang Haihui 
Published: December 2022

Background: Postmarketing safety analysis is an effective supplement for new drugs in clinical practice. Therefore, we aimed to systematically assess the safety of oral nemonoxacin malate, the first approved C-8-methoxy non-fluorinated quinolone, in clinical studies and via postmarketing safety surveillance.Methods: We electronically and manually searched and screened safety data (including premarketing and postmarketing data) of oral nemonoxacin from clinical registries. We standardized and summarized the reported adverse events according to the Medical Dictionary for Regulatory Activities System Organ Class and Preferred Terms. We summarized and reported the number and frequency (%) of the AEs and serious AEs in patients with community-acquired pneumonia and in specific patients.Results: Three Phase II/III comparator studies (n = 670, nemonoxacin), one Phase IV study (n = 461), two special population pharmacokinetic studies (n = 40), four observational studies (n = 1,852), and one 5-year postmarketing surveillance project (n = 257,420) were included in this study. The Phase II/III studies showed that the commonly reported drug-related AEs were similar for oral 500 mg nemonoxacin and levofloxacin treatments, which mainly included increased alanine aminotransferase levels (4.4% vs. 2.5%), neutropenia (2.5% vs. 4.4%), nausea (2.5% vs. 1.6%), and leukopenia (2.3% vs. 3.2%). No drug-related deaths were reported. Postmarketing safety surveillance revealed that known adverse drug reaction characteristics were generally unchanged. Pharmacokinetic data suggested that dose adjustment was not necessary in elderly patients, which was confirmed by a Phase IV study in an elderly population, in patients with renal impairment with CLcr ≥50 ml/min, and in those with mild-to-moderate hepatic impairment.Conclusion: Clinical trial data of approximately 1,450 patients and postmarketing data of &gt;257,420 patients suggest that nemonoxacin is generally well tolerated and can be a suitable alternative to fluoroquinolones for patients with CAP.
Triaxial closed-loop measurement based on a single-beam zero-field optically pumped magnetometer
Authors: Wang Kun , Zhang Kaixuan , Zhou Binquan , Lu Fei , Zhang Shaowen , Yan Yeguang , Wang Weiyi , Lu Jixi 
Published: December 2022

In this study, we propose an approach for the simultaneous measurement of triaxial magnetic fields using a single-beam zero-field optically pumped atomic magnetometer, in which a rotational high-frequency (ω1) and another high-frequency (ω2) modulated magnetic field magnetic fields are applied along the transverse directions and the longitudinal direction, respectively. Theoretical analysis, numerical simulation, and experiments are conducted to demonstrate this method. Experimental sensitivities of 18 fT/Hz1/2 along the two transverse directions and 140 fT/Hz1/2 along the longitudinal direction are simultaneously achieved. On this basis, we operate the magnetometer in closed-loop mode to expand the bandwidth and dynamic range, and to keep the triaxial magnetic field sensed by the magnetometer at zero. The triaxial bandwidths are increased from below 100 Hz to over 1.6 kHz. The triaxial dynamic ranges are all extended to ±150 nT. Plus, we verify the ±1,000 nT dynamic range of the triaxial magnetometer through increasing the triaxial coil constants. The synchronization of triaxial closed-loop measurement, simplicity of magnetometer structure, and closed-loop detection with high sensitivities make it applicable and attractive for biomagnetism imaging in challenging environments.
Improving nitrogen contribution in maize post-tasseling using optimum management under mulch drip irrigation in the semiarid region of Northeast China
Authors: Hou Yunpeng , Xu Xinpeng , Kong Lili , Zhang Lei , Zhang Yitao , Liu Zhiquan 
Published: December 2022

Film-mulched drip irrigation has become an important strategy in maize cultivation in the semiarid region of Northeast China. Most farmers concentrate nitrogen (N) fertilizer use early in maize growth, which leads to low N use efficiency and large N losses. Therefore, a three-year (2018 to 2020) field experiment was conducted to determine the optimal N management strategy for maize under film mulch with drip irrigation in the semiarid region of Northeast China. The experiment included five treatments with the total amount of N fertilizer (210 kg N ha−1) applied in different proportions at sowing, sixth-leaf (V6), twelfth-leaf (V12), tasseling (VT), and blister (R2) stages of maize growth: N1, 100-0-0-0-0; N2, 50-50-0-0-0; N3, 30-50-20-0-0; N4, 20-30-30-20-0; and N5, 10-20-30-20-20. The control (CK) did not receive N fertilizer. Maize yield, N uptake and use, changes in soil inorganic N content, and N balance were investigated. Compared with the single basal application (N1), split-N applications (N2, N3, N4, N5) increased maize yield from 13.8% to 24.5% by increasing kernel number per ear and 1000-kernel weight and also improved N accumulation from VT to physiological maturity (PM) stages and its contribution to grain N uptake. In addition, compared with N1, split-N applications also decreased N losses by increasing inorganic N contents in the 0–40 cm soil layer and by decreasing N leaching in the 60–200 cm soil layer. Regression analysis demonstrated that N accumulation after the VT stage was positively related with maize yield. Among treatments, N4 had the highest yield, N recovery efficiency, agronomic efficiency, and partial factor productivity, with respective increases of 24.5%, 14.7 percentage point, 11.4 kg kg−1, and 11.4 kg kg−1 compared with those in N1. As a result, N losses were also reduced by 33.7% in N4 compared with those in N1. In conclusion, the split-N management strategy with four N applications under film-mulched drip irrigation has great potential to improve maize yield, increase N use efficiency, and reduce N loss in the semiarid region of Northeast China.
Space-valence mapping of social concepts: Do we arrange negative and positive ethnic stereotypes from left to right?
Authors: Kühne K. , Nenaschew K. , Miklashevsky A. 
Published: December 2022

IntroductionThe body-specificity hypothesis states that in right-handers, positive concepts should be associated with the right side and negative concepts with the left side of the body. Following this hypothesis, our study postulated that negative out-group ethnic stereotypes would be associated with the left side, and positive in-group stereotypes would be associated with the right side.MethodsThe experiment consisted of two parts. First, we measured the spatial mapping of ethnic stereotypes by using a sensibility judgment task, in which participants had to decide whether a sentence was sensible or not by pressing either a left or a right key. The sentences included German vs. Arabic proper names. Second, we measured implicit ethnic stereotypes in the same participants using the Go/No-go Association Task (GNAT), in which Arabic vs. German proper names were presented in combination with positive vs. negative adjectives. Right-handed German native speakers (N = 92) participated in an online study.ResultsAs predicted, in the GNAT, participants reacted faster to German names combined with positive adjectives and to Arabic names combined with negative adjectives, which is diagnostic of existing valenced in-and outgroup ethnic stereotypes. However, we failed to find any reliable effects in the sensibility judgment task, i.e., there was no evidence of spatial mapping of positive and negative ethnic stereotypes. There was no correlation between the results of the two tasks at the individual level. Further Bayesian analysis and exploratory analysis in the left-handed subsample (N = 9) corroborated the evidence in favor of null results.DiscussionOur study suggests that ethnic stereotypes are not automatically mapped in a body-specific manner.
Neurobiological outcomes of cognitive behavioral therapy for obsessive-compulsive disorder: A systematic review
Authors: Poli Andrea , Pozza Andrea , Orrù Graziella , Conversano Ciro , Ciacchini Rebecca , Pugi Daniele , Angelo Nicole Loren , Angeletti Lorenzo Lucherini , Miccoli Mario , Gemignani Angelo 
Published: December 2022

IntroductionObsessive-compulsive disorder (OCD) is characterized by recurrent distressing thoughts and repetitive behaviors, or mental rituals performed to reduce anxiety. Recent neurobiological techniques have been particularly convincing in suggesting that cortico-striatal-thalamic-cortico (CSTC) circuits, including orbitofrontal cortex (OFC) and striatum regions (caudate nucleus and putamen), are responsible for mediation of OCD symptoms. However, it is still unclear how these regions are affected by OCD treatments in adult patients. To address this yet open question, we conducted a systematic review of all studies examining neurobiological changes before and after first-line psychological OCD treatment, i.e., cognitive-behavioral therapy (CBT).MethodsStudies were included if they were conducted in adults with OCD and they assessed the neurobiological effects of CBT before and after treatment. Two databases were searched: PsycINFO and PubMed for the time frame up to May 2022.ResultsWe obtained 26 pre-post CBT treatment studies performed using different neurobiological techniques, namely functional magnetic resonance imaging (fMRI), Positron emission tomography (PET), regional cerebral blood flow (rCBF), 5-HT concentration, magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), Electroencephalography (EEG). Neurobiological data show the following after CBT intervention: (i) reduced activations in OFC across fMRI, EEG, and rCBF; (ii) decreased activity in striatum regions across fMRI, rCBF, PET, and MRI; (iii) increased activations in cerebellum (CER) across fMRI and MRI; (iv) enhanced neurochemical concentrations in MRS studies in OFC, anterior cingulate cortex (ACC) and striatum regions. Most of these neurobiological changes are also accompanied by an improvement in symptom severity as assessed by a reduction in the Y-BOCS scores.ConclusionCognitive-behavioral therapy seems to be able to restructure, modify, and transform the neurobiological component of OCD, in addition to the clinical symptoms. Nevertheless, further studies are necessary to frame the OCD spectrum in a dimensional way.
Comparing the Building Code Sawn Lumber’s Wet Service Factors (CM) with Four Commercial Wood Species Laboratory Tests
Authors: Bahtiar Effendi Tri , Denih Asep , Priadi Trisna , Putra Gustian Rama , Koswara Andiana , Nugroho Naresworo , Hermawan Dede 
Published: December 2022

Indonesian Wooden Building Code (SNI 7973-2013) has adopted the National Design Specification (NDS) for Wood Construction since 2013. A periodic harmonization of the building-code-designated values (i.e., reference design values and adjustment factors) with the experimental data of commercial wood species is necessary. This study aimed to compare the building code’s wet service factors (CM) with the laboratory test of some commercial wood species. Since wood is weaker when its moisture content is high, the wet service factor (CM) must adjust the sawn lumber reference design values if the building serves in wet or aquatic environments. Four commercial wood species, namely pine (Pinus merkusii), agathis (Agathis dammara), red meranti (Shorea leprosula), and mahogany (Swietenia mahagoni), were subjected to mechanical property tests. To calculate the empirical CM values, the mechanical properties tests were conducted on air-dry and wet wood. Instead of testing the full-sized timber, which contains the growth characteristics and defects, this study chose clear-wood specimens to resemble the boundary condition of the ceteris paribus (other things being equal). The wet (water-saturated) specimens were immersed in water for 65 days, and the test was carried out when the specimen was still immersed. The test arrangement imitated the submerged wood as the worst-case scenario of the wet environment where the construction serves, rather than green or partially immersed timber. As many as 40 specimens were tested to compare each mechanical property’s wet service factor; thus, this study reported 200 specimens’ laboratory test results. The empirical CM values to adjust the modulus of elasticity, modulus of rupture, shear strength parallel-to-grain, tensile strength parallel-to-grain, and maximum crushing strength (CM = 0.59, 0.76, 0.65, 0.73, and 0.67, respectively) were significantly lower than SNI 7973-2013 designated values (CM = 0.9, 0.85, 0.97, 1, and 0.8, respectively). The empirical CM for the compression stress perpendicular-to-grain at the proportional limit and that at the 0.04″ deformation (CM = 0.66) were slightly lower than the designated values (CM = 0.67), although they were not significantly different. This study resulted in lower empirical CM values than the designated ones, which found that the building code lacked conservativeness. The lacked conservativeness is mainly attributed to the building code’s recent choices, e.g., (1) the wet service environment basis is the green timber rather than the fully water-saturated one, and (2) the ratio of near minimum (5% lower) distribution value is chosen as the CM value rather than the average of wet timber’s mechanical property divided by the air-dry one. This study proposes changing both recent choices to alternative ones to develop more safe and reliable designated CM values.