bluuebunny/crossref_metadata_2025_split huggingface dataset:
How do keystones govern their business ecosystems through resource orchestration?
Authors: Cui Miao , Li Wanling , Cui Li , Jia Yibo , Wu Lin 
Published: April 2022

PurposeSharing resources with stakeholders is the key for keystones to govern business ecosystems successfully. However, existing research has not paid further attention to how keystones share resources under the condition of resource sufficiency and how keystones balance resource sharing with complementors when they lack resources. Therefore, this paper aims to explore how keystones govern their business ecosystems under the conditions of resource sufficiency and resource insufficiency.Design/methodology/approachThis paper adopts the single case study method. First, by adopting Gioia coding to analyze the relevant data of the case sample, this paper obtains the key concepts of the business ecosystem governance process. Then, it establishes the relationship between the concepts by analyzing the governance process of the case sample.FindingsUnder the condition of resource sufficiency, keystones under the condition of resource sufficiency, should make full use of resources to incubate more complementors, and further integrate the resources of the business ecosystem, to create more value for their business ecosystems. Under the condition of resource insufficiency, keystones should break the boundaries of business ecosystems and acquire external resources, to meet the resource needs of complementors. Subsequently, keystones should redeploy idle resources according to the actual needs of complementors, to meet the changing resource needs of complementors.Originality/valueThis study subdivides business ecosystem governance conditions and further constructs the business ecosystem governance process model, which provides a theoretical and practical reference for business ecosystem governance.
Growing from the South in the seed market: Grupo Don Mario
Authors: Marin Anabel , Stubrin Lilia Ines , Palacín Roitbarg Rocío 
Published: April 2022

PurposeThe authors aim to draw lessons for research and policy from an exception(nal) case of a firm's international expansion in the seed market: Grupo Don Mario, a company originally from Argentina that supplies 20% of the soybean varieties used in the world. The authors describe the processes of expansion of the company, identify key features of its internationalisation, marketing and technological strategy and capabilities, and discuss implications for research and policy and questions for future research.Design/methodology/approachThis is a case study. The paper uses quantitative and qualitative information collected from existing datasets and documents and new information from open ended interviews. This study method is exploratory.FindingsFirst, new entrants from emerging economies should and can adopt an unique technological and marketing approach that distinguish them from incumbents to be able to overcome entry barriers in global concentrated markets. Second, technological capacities need to be complemented with regulatory and political to succeed in highly dynamic, uncertain and regulated sectors like seeds.Research limitations/implicationsPolicies oriented to support business from emerging countries in highly dynamic sectors need to consider technological alternatives.Originality/valueGrupo Don Mario is a case of great interest since it expanded in a period in which the global seed market concentrated massively through an unprecedented process of mergers and acquisitions, which involved the disappearance of hundreds of independent seed companies.
Factors affecting academic staff development in the context of university autonomy through the lens of stakeholders: a case study from Tay Nguyen University, Vietnam
Authors: Ngo Hieu Thi , Niem Le Duc , Tran Phong Cong , Nguyen Truc Thanh , Doan Dung Thi , Ngo Huyen Thi 
Published: April 2022

PurposeThis paper aims at identifying perceived factors and measuring opinions about the factors' impact on academic staff development (ASD) at Tay Nguyen University (TNU), Dak Lak, Vietnam.Design/methodology/approachThe research used the exploratory factor analysis (EFA) method, the multiple regression model (ordinary least squares (OLS)) and a five-point Likert scale questionnaire. A sample of 70 managerial staff, 374 lecturers and 512 students of TNU was surveyed to obtain data.FindingsThe EFA showed that opinions concerning university autonomy (UA) and university social responsibility (USR) were positively correlated. With the above two factors united as responsible autonomy (RA), the OLS indicated perceptions that RA and internal driving factor (IF) had significant and positive impacts on the ASD, while external driving factor (EF) was found to have a perceived negative influence on ASD.Research limitations/implicationsThe results indicated that there appears to be a close relationship between UA and USR, and these can be considered as a factor that has apparent impacts on the ASD of the university.Practical implicationsThe degree of UA and USR of TNU should be enhanced through awareness of the university's academic staff, the application of a suitable evaluation system and the efficiency of university's regulations. In addition, efforts should be made to improve internal factors such as the dissemination of educational philosophy, the suitability of strategic plans, the development of key performance indicators KPIs and the building of organizational culture – all of which will help to heighten the university’s ASD. At the same time, TNU should endeavor to quickly transform aspects of administration and management to meet the shifting requirements of the autonomous environment and competitive features of the market economy. In particular, there is a need for the academic staff themselves to have increased capacity to adapt to these changes.Social implicationsThe authors' results have a broader application to not only the case of TNU but to other situations in developing countries where universities are in transitional stages as governments assign increasing autonomy and responsibility to them.Originality/valueThis paper suggests that the academic staff of TNU should be provided with both professional autonomy and adaptive capacity to foster research and educational innovation in the market-based higher education system of Vietnam. More generally, if true, the paper suggests that an increase in the degree of UA and USR should be combined with the efforts to improve the internal environments such as disseminating educational philosophy, mission, vision and strategies and building organizational culture.
Drivers and barriers of Industry 4.0 technology adoption among manufacturing SMEs: a systematic review and transformation roadmap
Authors: Ghobakhloo Morteza , Iranmanesh Mohammad , Vilkas Mantas , Grybauskas Andrius , Amran Azlan 
Published: April 2022

PurposeThe present study offers a holistic but detailed understanding of the factors that might affect small and medium-sized enterprises (SMEs) adoption of Industry 4.0 technologies to empower smaller businesses to embrace Industry 4.0.Design/methodology/approachThe study conducted a systematic review of the literature and drew on the technology-organization-environment framework to identify various technological, organizational and environmental determinants of Industry 4.0 technology adoption and their underlying components. The study applied the textual narrative synthesis to extract findings from the eligible articles and interpret them into the Industry 4.0 technology adoption roadmap.FindingsIndustry 4.0 is a vital strategic option to SMEs, enabling them to keep up with the digitalization race. SMEs significantly lag behind large organizations in benefiting from disruptive Industry 4.0 technologies. SMEs are still struggling with the initial adoption decisions regarding the digital transformation under Industry 4.0. Results identified various determinants that might explain this condition. The study developed a digitalization roadmap that describes the necessary conditions for facilitating SMEs’ digitalization under Industry 4.0.Practical implicationsVarious technological, organizational and environmental factors might determine the current positioning of SMEs against Industry 4.0. These determinants can act as barriers or drivers depending on their properties. The roadmap describes determinants indispensable to promoting Industry 4.0 technology adoption among SMEs, such as knowledge competencies or value chain digitalization readiness.Originality/valueExclusively focusing on empirical research that reported applied insights into Industry 4.0 technology adoption, the study offers unique implications for promoting Industry 4.0 digital transformation among SMEs.
Research on innovation features and optimization strategies of industrial clusters from the perspective of TLCN
Authors: Luo Yongcong , Zheng Jianzhuang , Ma Jing 
Published: April 2022

PurposeThe focus of industrial cluster innovation lies in the cooperation between enterprises and universities/scientific research institutes to make a theoretical breakthrough in the system and mechanism of industrial cluster network. Under the theoretical framework of cluster network, industrial structure can be optimized and upgraded, and enterprise benefit can be improved. Facing the increasing proliferation and multi-structured enterprise data, how to obtain potential and high-quality innovation features will determine the ability of industrial cluster network innovation, as well as the paper aims to discuss these issues.Design/methodology/approachBased on complex network theory and machine learning method, this paper constructs the structure of “three-layer coupling network” (TLCN), predicts the innovation features of industrial clusters and focuses on the theoretical basis of industrial cluster network innovation model. This paper comprehensively uses intelligent information processing technologies such as network parameters and neural network to predict and analyze the industrial cluster data.FindingsFrom the analysis of the experimental results, the authors obtain five innovative features (policy strength, cooperation, research and development investment, centrality and geographical position) that help to improve the ability of industrial clusters, and give corresponding optimization strategy suggestions according to the result analysis.Originality/valueBuilding a TLCN structure of industrial clusters. Exploring the innovation features of industrial clusters. Establishing the analysis paradigm of machine learning method to predict the innovation features of industrial clusters.
Investigating meaningful impact in adolescent writing achievement within a high‐stakes testing context
Authors: Smit Julie , Lesley Mellinee , Baker‐Beach Whitney , Stewart Elizabeth 
Published: April 2022

BackgroundThis case study examined the consequences of a literacy initiative designed to improve writing instruction for a high school under pressure to increase standardised test scores or face government oversight. Realities of underperforming schools, such as interruptions to instructional time, a focus on formulaic essay writing and decontextualised grammar skills, high teacher turnover, and a disproportionately large percentage of students with low ability levels, impact the implementation and sustainability of research‐based practices. Thus, we embarked on a school‐university partnership designed to overcome these barriers. We co‐constructed research to determine the effectiveness of an instructional framework designed by the school's instructional coach (a teacher educator hired by the school district responsible for enacting literacy reform and providing professional development) and her work with four ninth‐grade and tenth‐grade English teachers (Years 10 and 11) in the United States. This engaged scholarship process empowered teachers and the instructional coach to make changes in their approach to writing instruction.MethodsOur case study used the following data sources: teacher and student interviews, professional development and classroom observations, student writing attitude surveys and analyses of student writing. We utilised grounded theory to determine changes in classroom practice and students' academic growth.ResultsOur study revealed strengths of the professional development regarding classroom management and student writing dispositions. Yet it also illuminated problems such as continued emphasis on reading instruction, limited opportunities for student choice and lack of writing strategies that transferred to composing extended text.ConclusionThese results raised critical questions, which aided the instructional coach in refining professional development for writing instruction.
COVID‐19: Omicron – the latest, the least virulent, but probably not the last variant of concern of SARS‐CoV‐2
Authors: Brüssow Harald 
Published: April 2022

SummaryThe Omicron variant rapidly became the dominant SARS‐CoV‐2 strain in South Africa and elsewhere. This review explores whether this rise was due to an increased transmission of the variant or its escape from population immunity by an extensively mutated spike protein. The mutations affected the structure of the spike protein leading to the loss of neutralization by most, but not all, therapeutic monoclonal antibodies. Omicron also shows substantial immune escape from serum antibodies in convalescent patients and vaccinees. A booster immunization increased, however, the titre and breadth of antiviral antibody response. The cellular immune response against Omicron was largely preserved explaining a satisfying protection of boosted vaccinees against severe infections. Clinicians observed less severe infection with Omicron, but other scientists warned that this must not necessarily reflect less intrinsic virulence. However, in animal experiments with mice and hamsters, Omicron infections also displayed a lesser virulence than previous VOCs and lung functions were less compromised. Cell biologists demonstrated that Omicron differs from Delta by preferring the endocytic pathway for cell entry over fusion with the plasma membrane which might explain Omicron’s distinct replication along the respiratory tract compared with Delta. Omicron represents a distinct evolutionary lineage that deviated from the mainstream of evolving SARS‐CoV‐2 already in mid‐2020 raising questions about where it circulated before getting widespread in December 2021. The role of Omicron for the future trajectory of the COVID‐19 pandemic is discussed.
Employees striving for innovation in social enterprises: The roles of social mission and commitment‐based human resource management
Authors: Chang Eunmi , Lee Jeong Won , Chin Hyun 
Published: April 2022

AbstractSocial enterprises, promising organizations for solving societal problems with innovative approaches, rely upon their members’ active roles for workplace innovation. However, we still have a limited understanding about how social enterprises can foster employees’ endeavors for innovation. By focusing on employee learning and innovative behavior, we investigate the influences of perceived social mission, value congruence, and human resource management (HRM) practices in social enterprises. We conducted two complementary studies to answer our research questions. In Study 1, with a survey of 369 employees from 68 social enterprises, we examined a multilevel moderated mediation model with firm‐level and individual‐level data. We found that perceived social mission promoted learning and innovative behavior by increasing value congruence, and that commitment‐based HRM practices enhanced the overall process from mission to employee efforts for innovation. In Study 2, with 300 daily surveys from 60 employees participating in an experience sampling study, we found that those with high‐value congruence showed a significantly more stable pattern with less variance in innovative behavior than in learning behavior. Our study adds novel implications to the underdeveloped literature on employee innovation and HRM in social enterprises by uncovering the positive effects of social mission and value facets for boosting learning and innovative behaviors. Our research also suggests that social enterprises should benefit from pursuing and emphasizing the social mission and commitment‐based HRM bundle together, which will promote the prosperity and well‐being of business and society.
Impact of cardiac dysfunction on morbidity and mortality in liver transplant candidates
Authors: Mohammadi Fadak , Ramachandran Jeyamani , Woodman Richard , Muller Kate , John Libby , Chen John , Wigg Alan 
Published: April 2022

AbstractThe prognostic role of cardiac dysfunction in cirrhotic patients is increasingly recognized. We studied its impact on morbidity and mortality before and after liver transplantation (LT) including development of post‐transplant cardiovascular disease (CVD). In this retrospective study, cirrhotic patients who underwent LT assessment from January 2010 to December 2020 were reviewed. Demographics, cardiac investigations and clinical courses were analyzed to identify the prevalence of cardiac dysfunction and its role in LT outcomes. Survival analysis was performed using Cox proportional hazard regression modelling, with LT as a time‐varying covariate and as an interaction variable with cardiac dysfunction. Three hundred and eight patients (70% male) were studied. The median (interquartile range) age at LT assessment was 56 (12) years. Cardiac dysfunction was found in 178 (58%) patients (diastolic, 169; systolic, 26; both, 17) and was significantly associated with hepatorenal syndrome/acute kidney injury and peri‐ and post‐transplant morbidity (adjusted odds ratio [aOR] 1.94, 95% CI 1.06–3.52, P < .001; aOR 2.01, 95% CI 1.06–3.82, P = .033; aOR 1.9, 95% CI 1.01–3.65, P = .023, respectively). Cardiac dysfunction was not associated with mortality before (adjusted hazard ratio [aHR] 1.01, 95% CI .99–1.01) or after LT (aHR .74, 95% CI .4–1.05. Post‐transplant CVD (61% cardiac failure) occurred in 36 patients, and there was no significant association with cardiac dysfunction (P = .11). Cardiac dysfunction was common in LT candidates and was significantly associated with morbidity before and after LT. Studies on the role of advanced echocardiographic parameters to improve diagnosis of cardiac dysfunction and optimize LT outcomes are needed.
Combined therapy with CD4+CD25highCD127− T regulatory cells and anti‐CD20 antibody in recent‐onset type 1 diabetes is superior to monotherapy: Randomized phase I/II trial
Authors: Zieliński Maciej , Żalińska Magdalena , Iwaszkiewicz‐Grześ Dorota , Gliwiński Mateusz , Hennig Matylda , Jaźwińska‐Curyłło Anna , Kamińska Halla , Sakowska Justyna , Wołoszyn‐Durkiewicz Anna , Owczuk Radosław , Młynarski Wojciech , Jarosz‐Chobot Przemysława , Bossowski Artur , Szadkowska Agnieszka , Siebert Janusz , Myśliwiec Małgorzata , Marek‐Trzonkowska Natalia , Trzonkowski Piotr 
Published: April 2022

AbstractAimsMonotherapy with autologous expanded CD4+CD25highCD127− T regulatory cells (Tregs) or rituximab has been documented to slow disease progression in patients with recent‐onset type 1 diabetes mellitus (T1DM). Whether a combined therapy including both drugs would further benefit this patient population is unknown.Materials and MethodsWe conducted a three‐arms clinical trial to explore the efficacy and safety of the combined treatment with Tregs and rituximab in paediatric patients with T1DM. The patients were allocated to three groups: Tregs only (n = 13), Tregs + rituximab (n = 12) and control (n = 11). The key primary efficacy analyses were C‐peptide levels (mixed meal tolerance test) and the proportion of patients in remission at 12 and 24 months.ResultsAt month 24, as compared with the control, both treatment groups remained superior in the area under the curve of C‐peptide mixed meal tolerance test, whereas in the analysis of all visits only the combined therapy improved area under the curve at 12 and 24 months. The proportion of patients in remission was significantly higher in the combined group than in the control group at 3, 6, 9 and 21 months but not at 18 and 24 months. There was no significant difference between the Tregs only group and control group. Adverse events occurred in 80% patients, mostly in the combined group and Tregs only group. No adverse events led to the withdrawal of the intervention or death. All comparisons were performed with alpha level of 5%.ConclusionsOver 2 years, combined therapy with Tregs and rituximab was consistently superior to monotherapy in delaying T1DM progression in terms of C‐peptide levels and the maintenance of remission.
Extracellular vesicles from bone marrow stromal cells reduce the impact of stroke on glial cell activation and blood brain‐barrier permeability via a putative miR‐124/PRX1 signalling pathway
Authors: Tian Jianan , Yao Haiqian , Liu Yihang , Wang Xiaokun , Wu Jiarong , Wang Jia , Yu Dan , Xie Yibo , Gao Jiaqi , Zhu Yulan , Yang Chunxiao 
Published: April 2022

AbstractIschaemic stroke (IS) is a cerebrovascular disease caused by cerebral infarction and cerebral artery occlusion. In this study, we proposed that EVs from bone marrow stromal cells (BMSCs) could reduce the impact of stroke by reducing the resultant glial cell activation and blood–brain barrier (BBB) leak. We furthermore investigated some of the signalling mechanisms. The transient middle cerebral artery occlusion (t‐MCAO) mouse model was established. The behavioural deficits and neuronal damage were verified using Bederson's scale and the 28‐point neurological score. The area of cerebral infarction was detected. The expressions of astrocytes/microglia markers and BBB permeability were evaluated by 2,3,5‐triphenyltetrazolium chloride (TTC) staining. The internalization of EVs by astrocytes/microglia in the peripheral area was detected by fluorescence labelling. The expressions of astrocyte/microglia markers were measured by RT‐qPCR. Levels of TNF‐α and IL‐1β in microglia were detected by ELISA. BBB permeability was evaluated. The downstream target genes and pathway of miR‐124 were analysed. Microglia/astrocytes were treated by oxygen–glucose deprivation reoxygenation (OGD/R). OGD/R microglia/astrocyte conditioned medium was used to culture bEnd.3 cells. The transendothelial electric resistance (TEER) of bEnd.3 cells was measured, and BBB permeability was characterized. Our results suggested that EVs from BMSCs can indeed reduce the extent of stroke‐mediated damage and evidenced that these effects are mediated via expression of the non‐coding RNA, miR‐124 that may act via the peroxiredoxin 1 (PRX1). Our results provided further motivation to pursue the use of modified EVs as a treatment option for neurological diseases.