bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of UV irradiation time on the molecular structure of typical engineering plastics and tribological properties under heavy load
Authors: Liu Lian , Duan Haitao , Zhan Wen , Zhan Shengpeng , Jia Dan , Li Yinhua , Li Changchun , An Jiangfeng , Du Chongwei , Li Jian 
Published: January 2022

Exposing engineering plastics to UV irradiation can easily destroy the original molecular structure of the materials and consequently affect their tribological properties. This study investigated the effects of UV irradiation on the molecular structure of typical engineering plastics, such as polytetrafluoroethylene (PTFE) and polyether ether ketone (PEEK), and on their tribological properties under heavy loads (20 MPa). The surface morphology results showed that the appearance of PEEK changed significantly under UV irradiation. However, the change in PTFE was negligible. Under micromorphology, the processing lines of the two materials gradually became lighter with increasing UV irradiation time. The resulting infrared spectra showed that the molecular chains of both materials were broken, and new functional groups were formed under UV irradiation. Tribology testing demonstrated that with prolonged UV irradiation, the average PTFE coefficient of friction remained relatively stable, whereas that of PEEK was approximately 0.55. As the UV irradiation time increased, the wear rate of PTFE increased significantly, whereas that of PEEK showed no significant change.
Evaluation of the Clinical Impact of Thromboprophylaxis in Patients With COVID-19 Following Hospital Discharge
Authors: Courtney Lindsay A. , Trujillo Toby C. , Saseen Joseph J. , Wright Garth , Palkimas Surabhi 
Published: January 2022

Background: Data are limited regarding the incidence of thromboembolism post-hospital discharge among COVID-19 patients. Guidelines addressing the role of extended thromboprophylaxis for COVID-19 patients are limited and conflicting. Objective: The purpose of this study was to evaluate the incidence of post-discharge thromboembolic and bleeding events and the role of thromboprophylaxis among COVID-19 patients. Methods: A retrospective analysis was conducted of hospitalized patients with symptomatic COVID-19 infection who were discharged from a University of Colorado Health (UCHealth) hospital between March 1, 2020, and October 31, 2020. The primary outcome was objectively confirmed thromboembolism within 35 days post-discharge. The main secondary outcome was the incidence of bleeding events within 35 days post-discharge. Outcomes were compared between those who received extended prophylaxis and those who did not. Results: A total of 1171 patients met the study criteria. A total of 13 (1.1%) of patients had a documented thromboembolic event and 10 (0.9%) patients had a documented bleeding event within 35 days post-discharge. None of the 132 patients who received extended prophylaxis had a thromboembolic event compared to 13 of 1039 who did not receive extended prophylaxis (0 and 1.3%, respectively; P = .383). The incidence of bleeding was higher among patients who received extended prophylaxis compared to those who did not (3.0% vs 0.6%, P = .019). Conclusions and Relevance: These results suggest that post-discharge extended prophylaxis may be beneficial for select COVID-19 patients, while carefully weighing the risk of bleeding. Application of our findings may assist institutions in development of thromboprophylaxis protocols for discharged COVID-19 patients.
Effects of the Ankle Flexion Angle During Anterior Talofibular Ligament Reconstruction on Ankle Kinematics, Laxity, and In Situ Forces of the Reconstructed Graft
Authors: Sakakibara Yuzuru , Teramoto Atsushi , Takagi Tetsuya , Yamakawa Satoshi , Shoji Hiroaki , Okada Yohei , Kobayashi Takuma , Kamiya Tomoaki , Fujimiya Mineko , Fujie Hiromichi , Watanabe Kota , Yamashita Toshihiko 
Published: January 2022

Background: This study aimed to evaluate the effects of the ankle flexion angle during anterior talofibular ligament (ATFL) reconstruction on ankle kinematics, laxity, and in situ force of a graft. Methods: Twelve cadaveric ankles were evaluated using a 6–degrees of freedom robotic system to apply passive plantar flexion and dorsiflexion motions and multidirectional loads. A repeated measures experiment was designed using the intact ATFL, transected ATFL, and reconstructed ATFL. During ATFL reconstruction (ATFLR), the graft was fixed at a neutral position (ATFLR 0 degrees), 15 degrees of plantar flexion (ATFLR PF15 degrees), and 30 degrees of plantar flexion (ATFLR PF30 degrees) with a constant initial tension of 10 N. The 3-dimensional path and reconstructed graft tension were simultaneously recorded, and the in situ force of the ATFL and reconstructed grafts were calculated using the principle of superposition. Results: The in situ forces of the reconstructed grafts in ATFLR 0 degrees and ATFLR PF 15 degrees were significantly higher than those of intact ankles. The ankle kinematics and laxity produced by ATFLR PF 30 degrees were not significantly different from those of intact ankles. The in situ force on the ATFL was 19.0 N at 30 degrees of plantar flexion. In situ forces of 41.0, 33.7, and 21.9 N were observed at 30 degrees of plantar flexion in ATFLR 0, 15, and 30 degrees, respectively. Conclusion: ATFL reconstruction with the peroneus longus (PL) tendon was performed with the graft at 30 degrees of plantar flexion resulted in ankle kinematics, laxity, and in situ forces similar to those of intact ankles. ATFL reconstructions performed with the graft fixed at 0 and 15 degrees of the plantar flexion resulted in higher in situ forces on the reconstructed graft. Clinical Relevance: Fixing the ATFL tendon graft at 30 degrees of plantar flexion results in an in situ force closest to that of an intact ankle and avoids the excessive tension on the reconstructed graft.
Nephrotic syndrome induced by cetuximab in a patient with metastatic colorectal cancer
Authors: Korkmaz Mustafa , Hendem Engin , Karakurt Eryılmaz Melek , Demirkıran Aykut , Karaağaç Mustafa , Artaç Mehmet 
Published: January 2022

Introduction Cetuximab, an anti-EGFR monoclonal antibody, often cause skin toxicity, most commonly acneiform rash. We present a rare case of glomerulonephritis associated with cetuximab therapy. Case Report A 58-year-old male patient recently completed cetuximab-based chemotherapy for metastatic colorectal adenocarcinoma. He presented with acute renal failure, anasarca edema and nephrotic proteinuria. The amount of protein in the 24-h urine test was over 15.6 grams. Management & Outcome The patient showed a dramatic improvement in renal function shortly after terminated of cetuximab therapy without immunosuppressive therapy. Discussion Therefore, drugs targeting epidermal growth factor receptor (EGFR) monoclonal antibody were thought to trigger nephrotic syndrome by causing glomerular damage. As a result, physicians using EGFR monoclonal inhibitors should be very careful about renal functions and proteinuria in patients.
Association between health-related quality of life and menopausal status and symptoms in women living with HIV aged 45–60 years in England: An analysis of the PRIME study
Authors: Okhai Hajra , Dragomir Livia , Pool Erica RM , Sabin Caroline A , Miners Alec , Sherr Lorraine , Haag Katharina , Dhairyawan Rageshri , Vora Nina , Sultan Binta , Gilson Richard , Burns Fiona , Gilleece Yvonne , Jones Rachael , Post Frank , Ross Jonathan , Ustianowski Andrew , Tariq Shema 
Published: January 2022

Objectives: The aim of this study was to compare the health-related quality of life between mid-life women with HIV and the general population and to investigate the association between health-related quality of life and menopausal (1) status and (2) symptoms among women with HIV. Methods: Cross-sectional data of women with HIV aged 45–60 years from the Positive Transitions Through the Menopause Study. Health-related quality of life was assessed using the Euroqol questionnaire with utility scores categorizing health as perfect (score = 1.00), sub-optimal (0.75–0.99) or poor (< 0.75). Scores were compared between Positive Transitions Through the Menopause study participants and women (aged 45–59 years) from the Health Survey for England. Associations between health-related quality of life and menopausal status/symptoms in Positive Transitions Through the Menopause participants were assessed using a multivariable two-part regression model, the results of which are combined to produce a single marginal effect. Results: In total, 813 women from the Positive Transitions Through the Menopause study were included (median age 49 (interquartile range: 47–53) years); the majority were of Black African ethnicity (72.2%). Overall, 20.9%, 43.7% and 35.3% of women were pre-, peri- and post-menopausal, respectively, and 69.7% experienced mild/moderate/severe menopausal symptoms. Approximately, 40% reported perfect health, 22.1% sub-optimal health and 39.0% poor health, similar to women from the Health Survey for England (perfect health: 36.9%, sub-optimal health: 25.2%, poor health: 37.9%). In multivariable models, we found an association between health-related quality of life and peri-menopausal status (marginal effect: 0.07 (0.02, 0.12)); however, the association with post-menopausal status was attenuated (marginal effect: 0.01 (–0.05, 0.06)). There remained a strong association between lower utility scores and moderate (marginal effect: 0.16 (0.11, 0.20)) and severe (marginal effect: 0.32 (0.27, 0.39)) menopausal symptoms. Conclusion: There were no differences in health-related quality of life between women with HIV (Positive Transitions Through the Menopause participants) and women from the Health Survey for England dataset. Among Positive Transitions Through the Menopause participants, health-related quality of life was reduced in peri-menopausal women and those with increasingly severe menopausal symptoms. Our findings highlight the importance of proactive assessment of menopausal status and symptoms to optimize health-related quality of life in women living with HIV as they reach mid-life and beyond.
Is a small-caliber or large-caliber endoscope more suitable for colonic self-expandable metallic stent placement? A randomized controlled study
Authors: Minoda Yosuke , Ogino Haruei , Sumida Yorinobu , Osoegawa Takashi , Itaba Soichi , Hashimoto Norikazu , Esaki Mitsuru , Kitagawa Yusuke , Yodoe Kentaro , Iboshi Yoichiro , Matsuguchi Takahiro , Tadokoro Mei , Chaen Tomohito , Kubo Hiroaki , Kubokawa Masaru , Harada Naohiko , Nishizima Kenichi , Fujii Hiroyuki , Hata Yoshitaka , Tanaka Yoshimasa , Ihara Eikichi , Ogawa Yoshihiro 
Published: January 2022

Objectives: The colonic self-expandable metallic stent (C-SEMS) with a 9-French (Fr) delivery system allows for a small-caliber endoscope (SCE) to be used to treat malignant colonic obstruction. Despite the lack of evidence, the SCE has become popular because it is considered easier to insert than the large-caliber endoscope (LCE). We aimed to determine whether the SCE is more suitable than the LCE for C-SEMS placement. Methods: Between July 2018 and November 2019, 50 consecutive patients who were scheduled to undergo C-SEMS for colon obstruction were recruited in this study. Patients were randomized to the SCE or LCE group. The SCE and LCE were used with 9-Fr and 10-Fr delivery systems, respectively. The primary outcome was the total procedure time. Secondary outcomes were the technical success rate, complication rate, clinical success rate, insertion time, guidewire-passage time, stent-deployment time, and colonic obstruction-scoring-system score. Results: Forty-five patients (SCE group, n = 22; LCE group, n = 23) were analyzed. The procedure time in the LCE group (median, 20.5 min) was significantly ( p = 0.024) shorter than that in the SCE group (median, 25.1 min). The insertion time in the LCE group (median, 2.0 min) was significantly ( p = 0.0049) shorter than that in the SCE group (median, 6.0 min). A sub-analysis of the procedure difficulties showed that the insertion time in the LCE group (median, 5.0 min) was significantly shorter than that in the SCE group (median, 8.5 min). Conclusion: Both LCE and SCE can be used for C-SEMS; however, LCE is more suitable than SCE as it achieved a faster and equally efficacious C-SEMS placement as that of SCE. Clinical trial registration number: University Hospital Medical Information Network Clinical Trials Registry (UMIN 32748)
Do Personality Traits Influence the Association Between Depression and Dementia in Old Age?
Authors: Adaralegbe Adeleye A. , Egbuchiem Henry , Adeoti Oluwatomi , Abbasi Khuzeman , Ezeani Esther , Adaralegbe Ngozi Jane-Frances , Babarinde Abdulraheem Olaide , Boms Maureen , Nzeako Chidiebube , Ayeni Olumide 
Published: January 2022

Depression and personality traits are independent predictors of dementia or cognitive impairment. Despite the well-established relationship between these two psychosocial factors and dementia, no research has been documented on how personality traits can influence dementia in older adults exhibiting depressive symptoms. This study explores the influence of personality traits on the association between change in depression and dementia in old age. A population-based longitudinal cohort study involving two waves of data collected 5 years apart, containing 2210 American older adults, from the National Social Life, Health, and Aging Project to explore if personality traits influence how change in depression predicts the development of dementia. We assessed these relationships while adjusting for sociodemographic characteristics. Change in depression increased the likelihood of dementia at T2 by 4.2% (AOR = 1.04, p = 0.019) in the co-variate adjusted model. Personality traits, overall, did not influence how depression predicts the development of dementia. However, agreeableness individually nullified the effect of depression on the development of dementia, whereas extraversion was the only personality trait that significantly predicted dementia. Prosocial behaviors should be promoted in old age as these appear to be protective. In addition, early life education and a strong social support can keep the depression–dementia spectrum at bay in old age.
Diabetes Self-Care Behaviors and Barriers to Clinical Care During COVID-19 Pandemic for Marshallese Adults
Authors: Purvis Rachel S. , Moore Ramey A. , Ayers Britni L. , Felix Holly C. , Riklon Sheldon , Andersen Jennifer A. , Hudson Jonell S. , O’Connor Gail , Kelen Meetu , Heely-Rolston Lee-Ann Noelani , Shields Xochitl , McElfish Pearl A. 
Published: January 2022

Purpose: The purpose of the study was to explore experiences of Marshallese adults related to diabetes self-care behaviors during the COVID-19 pandemic. Methods: A qualitative descriptive design was utilized to understand participants’ diabetes self-care behaviors during the pandemic. Nine focus groups with 53 participants were held via videoconference and conducted in English, Marshallese, or a mixture of both languages. A priori codes based on diabetes self-care behaviors provided a framework for analyzing and summarizing participant experiences. Results: Both increases and decreases in healthy eating and exercise were described, with improvements in health behaviors attributed to health education messaging via social media. Participants reported increased stress and difficulty monitoring and managing glucose. Difficulty obtaining medication and difficulty seeing their health care provider regularly was reported and attributed to health care provider availability and lack of insurance due to job loss. Conclusions: The study provides significant insight into the reach of health education campaigns via social media and provides important information about the reasons for delays in care, which extend beyond fear of contracting COVID-19 to structural issues.
Arthroscopic Patellar Tendon Debridement and Distal Pole Osteoplasty for Recalcitrant Patellar Tendinopathy
Authors: Amirhekmat Arya , Stepanyan Hayk , Callan Kylie , Williams Riley , Wang Dean 
Published: January 2022

Background: Chronic patellar tendinosis is an overuse injury of the patellar tendon that commonly afflicts jumping athletes. Indications: For patients with refractory symptoms that do not respond to extensive physical therapy and rest, surgical management may be considered. Although both open and arthroscopic treatments have been described, arthroscopic treatment allows for more direct access to the diseased dorsal portion of the tendon and allows for faster return to activities and sport. Technique Description: Arthroscopic treatment involves debridement of the diseased portion of the patella tendon and osteoplasty of the distal pole of the patella. The infrapatellar fat pad is first debrided using an arthroscopic shaver and radiofrequency ablation device to the level of the dorsal surface of the patellar tendon. Under direct arthroscopic visualization and corresponding to the location of edema noted on the magnetic resonance image, the diseased portion of the patellar tendon is gently debrided with an arthroscopic shaver. Next, an osteoplasty of the distal pole of the patella is performed to facilitate bleeding and healing of the diseased tendon as well as eliminate any mechanical impingement. Any calcifications within the enthesis can be removed using an arthroscopic biter and resector. An arthroscopic resector is then used to decorticate and smoothen the distal pole of the patella to the level of healthy, bleeding cancellous bone. Results: Significant improvements in pain and function have been reported with arthroscopic treatment for chronic patellar tendinosis. Patients can expect a 90% return to sport rate following the procedure, with return to preinjury function as soon as 3 to 5 months. This procedure is well tolerated with minimal complications reported. Discussion: Arthroscopic patellar tendon debridement and distal pole osteoplasty can be used to treat chronic patellar tendinosis refractory to nonoperative treatment. Improvements in pain and function have been reported with this technique, along with a faster return to sport compared with traditional open techniques.
Topology preserving stratification of tissue neoplasticity using Deep Neural Maps and microRNA signatures
Authors: Kaczmarek Emily , Nanayakkara Jina , Sedghi Alireza , Pesteie Mehran , Tuschl Thomas , Renwick Neil , Mousavi Parvin 
Published: January 2022

Abstract
Background
Accurate cancer classification is essential for correct treatment selection and better prognostication. microRNAs (miRNAs) are small RNA molecules that negatively regulate gene expression, and their dyresgulation is a common disease mechanism in many cancers. Through a clearer understanding of miRNA dysregulation in cancer, improved mechanistic knowledge and better treatments can be sought.

Results
We present a topology-preserving deep learning framework to study miRNA dysregulation in cancer. Our study comprises miRNA expression profiles from 3685 cancer and non-cancer tissue samples and hierarchical annotations on organ and neoplasticity status. Using unsupervised learning, a two-dimensional topological map is trained to cluster similar tissue samples. Labelled samples are used after training to identify clustering accuracy in terms of tissue-of-origin and neoplasticity status. In addition, an approach using activation gradients is developed to determine the attention of the networks to miRNAs that drive the clustering. Using this deep learning framework, we classify the neoplasticity status of held-out test samples with an accuracy of 91.07%, the tissue-of-origin with 86.36%, and combined neoplasticity status and tissue-of-origin with an accuracy of 84.28%. The topological maps display the ability of miRNAs to recognize tissue types and neoplasticity status. Importantly, when our approach identifies samples that do not cluster well with their respective classes, activation gradients provide further insight in cancer subtypes or grades.

Conclusions
An unsupervised deep learning approach is developed for cancer classification and interpretation. This work provides an intuitive approach for understanding molecular properties of cancer and has significant potential for cancer classification and treatment selection.
Genome-wide investigation of microRNAs and expression profiles during rhizome development in ginger (Zingiber officinale Roscoe)
Authors: Xing Haitao , Li Yuan , Ren Yun , Zhao Ying , Wu Xiaoli , Li Hong-Lei 
Published: January 2022

Abstract
Background
MicroRNAs (miRNAs) are endogenous, non-coding small functional RNAs that govern the post-transcriptional regulatory system of gene expression and control the growth and development of plants. Ginger is an herb that is well-known for its flavor and medicinal properties. The genes involved in ginger rhizome development and secondary metabolism have been discovered, but the genome-wide identification of miRNAs and their overall expression profiles and targets during ginger rhizome development are largely unknown. In this study, we used BGISEQ-500 technology to perform genome-wide identification of miRNAs from the leaf, stem, root, flower, and rhizome of ginger during three development stages.

Results
In total, 104 novel miRNAs and 160 conserved miRNAs in 28 miRNA families were identified. A total of 181 putative target genes for novel miRNAs and 2772 putative target genes for conserved miRNAs were predicted. Transcriptional factors were the most abundant target genes of miRNAs, and 17, 9, 8, 4, 13, 8, 3 conserved miRNAs and 5, 7, 4, 5, 5, 15, 9 novel miRNAs showed significant tissue-specific expression patterns in leaf, stem, root, flower, and rhizome. Additionally, 53 miRNAs were regarded as rhizome development-associated miRNAs, which mostly participate in metabolism, signal transduction, transport, and catabolism, suggesting that these miRNAs and their target genes play important roles in the rhizome development of ginger. Twelve candidate miRNA target genes were selected, and then, their credibility was confirmed using qRT-PCR. As the result of qRT-PCR analysis, the expression of 12 candidate target genes showed an opposite pattern after comparison with their miRNAs. The rhizome development system of ginger was observed to be governed by miR156, miR319, miR171a_2, miR164, and miR529, which modulated the expression of the SPL, MYB, GRF, SCL, and NAC genes, respectively.

Conclusion
This is a deep genome-wide investigation of miRNA and identification of miRNAs involved in rhizome development in ginger. We identified 52 rhizome-related miRNAs and 392 target genes, and this provides an important basis for understanding the molecular mechanisms of the miRNA target genes that mediate rhizome development in ginger.