bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Bench Press Exercise and Triceps Strength Bullet Rejection Ability to be Reviewed from the Flexibility of the Togok to FIK UNM Makassar Students
Authors: Anto Sukamto  , Hikmad Hakim  , Rahma Dewi  , Nurkadri  , Fransen Sinaga  
Published: October 2022

Fiction UNM Makassar student. The design used in this study is an experimental method using a 2x2 factorial design. This method is a test (validation) that is testing the effect of one or more variables on other variables. Factorial design is a research design by modifying the post-test-only control or pretest-posttest control group and the researcher adds other variables. The results of the research through hypothesis testing show that Farithmetic between columns (FA) = 26,444, looks bigger than = 4.113, it appears that > or P-value = 0.000 < 0.05 so H0 rejected and H1 accepted. Thus it can be concluded that overall there is a significant difference in the effect between bench press training and triceps strength on O'Brien's shot put ability to FIK UNM Makassar Students. interaction (FAB) = 163.155 and = 4.113, it appears that > or P-value = 0.000 < 0.05, so H0 rejected and H1 accepted. In other words, it can be stated that the achievement of the O'Brien style shot put ability is influenced by the interaction between the training method and the flexibility of the togok.
Analisis pengaruh perputaran modal kerja, struktur modal, dan ukuran perusahaan terhadap profitabilitas
Authors: Richard Ardo Muhamad , Masitoh Endang , Dewi Riana Rachmawati 
Published: October 2022

This study looks at how changes in working capital turnover, capital structure, and firm size can affect a profitability. This study covers period from 2016- 2020. The data used in this study annual report for property and real estate sector companies listed on the Indonesia Stock Exchange between 2016 and 2020 period. The population used in this study is all these companies. In this study, we use multiple linear regression analysis to analyze quantitative data. Sampling method using is objective sampling method Based on the sampling method, there are 13 company in the property and real estate sector that meet the criteria. Financial statement documentation The method used in this study is the method of collecting and recording annual report. The study looked at 65 samples from the company's annual report for 2016-2020. This Study found the working capital turnover and capital structure had an effect on profitability, while company size had no effect. The model determination test showed that the independent variables affected on profitability. This shows that an increase in working capital turnover and capital structure can increase on profitability, and conversely a decrease in working capital turnover and capital structure will reduce on profitability, but this shows that company size does not affect on profitability. Increasing or decreasing company size does not affect profit.
Capital Structure, Accounting Conservatism, Agency Cost, dan Firm Value
Authors: Aprianti Vika , Khomsiyah Khomsiyah 
Published: October 2022

The purpose of this research is to evaluate how capital structure, accounting conservatism, and agency cost impact firm value. The financial reports companies listed on the IDX in 2019–2021 are data utilized in this analysis. The website of the Indonesian Stock Exchange (IDX) supplied the information for this research. There are 671 companies listed in 2019, 716 in 2020, and 769 in 2021. The samples in this research are non-cylicals consumer sector companies. There are 87 companies which was fit the criteria. The study aimed to investigate whether capital structure, accounting conservatism, and agency cost had an effect on firm value. Consequently, there was no effect of the company's capital structure on firm value. This indicates that shareholders are not too focused on capital structure to assess a company. However, companies that had high agency costs followed by good management. Thus, firm value was also high because it could be taken into consideration by shareholders to oversee management actions to support a better firm value. Then, accounting conservatism which showed caution over uncertainty in maintaining the quality of reported earnings. Accounting conservatism has a negative effect on firm value, this indicates that shareholders prefer companies that do not carry out accounting conservatism so that there is no early recognition of losses and company profits remain high.
Pengaruh Produk Domestik Regional Bruto dan Upah Minimum Kabupaten Terhadap Penyerapan Tenaga Kerja Di Kabupaten Bogor Dari Tahun 2010 - 2020
Authors: Rasyid Harun Al , K Agus Tri Indah 
Published: October 2022

Penelitian ini bertujuan untuk mengetahui pengaruh produk domestik regional bruto, tingkat upah, terhadap penyerapan tenaga kerja di Kabupaten Bogor tahun 2010 -2020. Pendekatan yang digunakan adalah pendekatan kuantitatif dengan metode deskriptif. Jenis data dalam penelitian ini adalah data panel berupa sampel dari tahun 2010 - 2020 kabupaten Bogor dengan penyerapan tenaga kerja tertinggi pada tahun 2019 dengan jumlah 2,791,651 pekerja. Dalam penelitian ini digunakan analisis regresi linear berganda , dengan sistem komputerisasi menggunakan SPSS. Setelah melakukan penelitian dengan data sekunder, dapat disimpulkan ada dua variabel yang mempengaruhi Penyerapan Tenaga Kerja yaitu Produk Domestik Regional Bruto dan Upah Minimum Kabupaten. Hasil penelitian secara simultan atau bersama-sama dalam Uji F, Kedua variable independen yaitu Produk Domestik Regional Bruto dan Upah Minimum Kabupaten secara bersama-sama mempengaruhi Penyerapan Tenaga Kerja di Kota Kabupaten Bogor. Kemudian dengan uji t, Produk Domestik Regional Bruto tidak berpengaruh Positif dan signifikan terhadap Penyerapan Tenaga Kerja di Kabupaten Bogor. Upah Minimum Kota berpengaruh Positif signifikan terhadap Penyerapan Tenaga Kerja di Kota Kabupaten Bogor. maka diperoleh kesimpulan bahwa upah minimum Kabupaten berpengaruh terhadap Penyerapan tenaga kerja dan secara simultan terdapat pengaruh terhadap variabel bebas yaitu PDRB(X1) dan variabel UMK(X2) terhadap variabel terikat yaitu PTK(Y) dengan nilai adjusted R Square (R2) = 88%, serta 12% sisanya terpengaruh variabel lainnya.
AKUPRESUR DALAM MENGURANGI EMESIS GRAVIDARUM
Authors: Masdinarsah Imas 
Published: October 2022

ABSTRAK
Emesis gravidarum atau morning sikness yaitu keadaan ibu hamil trimester 1 mengeluh merasa mual muntah dalam 24 jam terjadi kurang dari 5 kali. Emesis gravidarum adalah rasa mual sera muntah yang dirasakan selama hamil, atau disebut juga dengan morning sickness. Hasil studi menyatakan lebih dari 80% wanita hamil mengalami emesis gravidarum sepanjang hari. Beberapa penelitian menyatakan emesis gravidarum terjadi pada primigravida 60-80%, pada multigravida 40-60% (Beatrice knight,2000). Rancangan penelitian ini quasi eksperimen dengan Pretest Only Design with Control Group. Subjek penelitian dibagi menjadi 2, yakni kelompok perlakuan dan kelompok kontrol. Pada kelompok perlakuan diberikan intervensi berupa akupresur dan pada kelompok kontrol diberikan vitamin B6. Akupresur diberikan kepada ibu hamil trimester 1 yang mengalami mual muntah selama 30 detik diulang selama 4 kali (lamanya sampai 2 menit). Sebelum dilakukan akupresur ibu diberikan pemahaman sugesti positif dalam menerima kehamilannya dahulu kemudian dilakukan akupresur. Tindakan akupresur untuk mengurangi mual muntah dilakukan pada titik P6 dan ST 32. Pada penelitian ini populasinya adalah seluruh ibu hamil Trimester I di Desa Jagabaya Kecamatan Cimaung Kabupaten Bandung, Sampel dalam penelitian ini adalah ibu hamil trimester 1 yang mengalami mual muntah . Metode pengumpulan data menggunakan data primer berupa tindakan akupresur pada ibu hamil trimester 1 di titik P6 dan ST 32. Pemantauan dilakukan pada 66 responden yaitu 33 orang responden sebagai kelompok perlakuan dan 33 orang responden sebagai kelompok kontrol dengan melihat keluhan dari ibu hamil trimester 1 yang mengalami emesis berkurang atau hilang. Analisa data menggunakan uji beda non parametrik (Mann Whitney Test) untuk melihat adanya perbedaan dari ibu yang mengalami emesis sebelum dilakukan akupresur dan sesudah dilakukan akupresur.
Predicting OCT images of short-term response to anti-VEGF treatment for retinal vein occlusion using generative adversarial network
Authors: Xu Fabao , Yu Xuechen , Gao Yang , Ning Xiaolin , Huang Ziyuan , Wei Min , Zhai Weibin , Zhang Rui , Wang Shaopeng , Li Jianqiao 
Published: October 2022

To generate and evaluate post-therapeutic optical coherence tomography (OCT) images based on pre-therapeutic images with generative adversarial network (GAN) to predict the short-term response of patients with retinal vein occlusion (RVO) to anti-vascular endothelial growth factor (anti-VEGF) therapy. Real-world imaging data were retrospectively collected from 1 May 2017, to 1 June 2021. A total of 515 pairs of pre-and post-therapeutic OCT images of patients with RVO were included in the training set, while 68 pre-and post-therapeutic OCT images were included in the validation set. A pix2pixHD method was adopted to predict post-therapeutic OCT images in RVO patients after anti-VEGF therapy. The quality and similarity of synthetic OCT images were evaluated by screening and evaluation experiments. We quantitatively and qualitatively assessed the prognostic accuracy of the synthetic post-therapeutic OCT images. The post-therapeutic OCT images generated by the pix2pixHD algorithm were comparable to the actual images in edema resorption response. Retinal specialists found most synthetic images (62/68) difficult to differentiate from the real ones. The mean absolute error (MAE) of the central macular thickness (CMT) between the synthetic and real OCT images was 26.33 ± 15.81 μm. There was no statistical difference in CMT between the synthetic and the real images. In this retrospective study, the application of the pix2pixHD algorithm objectively predicted the short-term response of each patient to anti-VEGF therapy based on OCT images with high accuracy, suggestive of its clinical value, especially for screening patients with relatively poor prognosis and potentially guiding clinical treatment. Importantly, our artificial intelligence-based prediction approach’s non-invasiveness, repeatability, and cost-effectiveness can improve compliance and follow-up management of this patient population.
A comparative analysis of molecular genotypes of Mycobacterium tuberculosis isolates from HIV-positive and HIV-negative patients
Authors: Singh Jitendra , Singh Niti , Suresh Gayatri , Srivastava Rahul , Aggarwal Upasna , Behera Digamber , Munisamy Murali , Malhotra Anvita Gupta , Singh Sarman 
Published: October 2022

SettingTuberculosis Research Laboratory, Division of Clinical Microbiology and Molecular Medicine, Department of Laboratory Medicine, All India Institute of Medical Sciences, and the National Institute of Tuberculosis and Respiratory Diseases (NITRD), both situated in New Delhi.ObjectivesWe aimed to identify the distribution of various genotypes of M. tuberculosis among HIV-positive and HIV-negative patients suspected of having Tuberculosis, seen at the National Institute of Tuberculosis and Respiratory Diseases, New Delhi, which is a tertiary care dedicated TB hospital.Patients and methodsGenotyping by Spoligotyping and 24 loci MIRU-VNTR was performed and analyzed using SITVITWEB and MIRU-VNTRplus. Drug susceptibility patterns were also analyzed.ResultsA total of 503 subjects who were PTB/EPTB suspected were recruited and 287 were culture positive. Among them, 276 had growth of Mycobacterium tuberculosis (MTB) and in 11 patients non-tuberculous mycobacteria (NTM) were grown. The isolation rate of NTM was predominantly from HIV positive [10 of 130 (7.6%)] patients. Of the total isolates of MTB, 156 (56.5%) were from HIV negative patients and 120 (43.5%) were from HIV positive patients. All 276 M. tuberculosis isolates were genotyped and tested for drug susceptibility patterns. The CAS genotype was most predominant [153 (55.4%)], followed by Beijing lineage [44 (15.9%)], East African India [25 (9.1%)] and others [54 (19.6%)]. Beijing genotype was significantly more common in HIV positive patients (22.5%) than in HIV negative patients (10.9%). In MIRU-VNTR analysis, clustering was found to be more frequent in CAS strains irrespective of HIV status. In the HIV positive group, spoligotyping could differentiate various genotypes in 90% of isolates and MIRU-VNTR analysis in 84.2% of isolates. The clustering of various MTB strains was more associated with drug resistance.ConclusionThe Beijing lineage was predominant in HIV-TB coinfected cases, even though the Central Asian Strain (CAS) was overall more predominant in the region.
Relationship between triglyceride–glucose index and carotid plaques in a high-stroke-risk population in southeast china: A population-based cross-sectional survey
Authors: Tang Xiang , Zhang Lulu , Li Yidan , Zhou Yun , Cai Xiuying , Yao Ye , Fang Qi 
Published: October 2022

BackgroundCervical arterial atherosclerosis (CAA) is an important risk factor of stroke in China. The triglyceride–glucose (TyG) index is a simple and low-cost marker for ischemic stroke. Whether the TyG index predicts cervical arterial atherosclerosis remains uncertain. This study aimed to investigate the relationship between the TyG index and cervical arterial atherosclerosis.MethodsThis cross-sectional study was conducted in residents aged ≥40 years in the general population of southeast China. All participants completed a detailed questionnaire and provided blood samples. The high-stroke-risk groups further completed cervical artery ultrasonography. The TyG index was calculated using a well-established formula and analyzed in quartiles (Q1–Q4). Multivariate logistic regression was used to investigate the relationship between the TyG index and cervical arterial atherosclerosis.ResultsA total of 4,499 participants aged ≥40 years were finally included, with 23.47% comprising the high-stroke-risk population. The prevalence rates of increased intima–media thickness (IMT), carotid plaque, and cervical artery stenosis (CAS) in the high-stroke-risk population were 21.97%, 39.3%, and 6.1%, respectively. Subjects with higher TyG were still more likely to have carotid plaque. After adjusting for several established risk factors, compared with the TyG-Q1 group, the TyG-Q2, TyG-Q3, and TyG-Q4 groups were more likely to have carotid plaque (OR = 1.85, 95%CI = 1.28–2.67; OR = 1.51, 95%CI = 1.05–2.18; and OR = 1.29, 95%CI = 0.90–1.84). TyG was an independent predictor of the presence of plaque in the carotid artery of the high-stroke-risk population.ConclusionsAn elevated TyG index is a potential predictor of carotid plaques in the high-stroke-risk population older than 40 years.
Implementation of corneal confocal microscopy for screening and early detection of diabetic neuropathy in primary care alongside retinopathy screening: Results from a feasibility study
Authors: Carmichael Josie , Fadavi Hassan , Ishibashi Fukashi , Howard Susan , Boulton Andrew J. M. , Shore Angela C. , Tavakoli Mitra 
Published: October 2022

ObjectiveScreening for diabetic peripheral neuropathy (DPN) is essential for early detection and timely intervention. Quantitative assessment of small nerve fiber damage is key to the early diagnosis and assessment of its progression. Corneal confocal microscopy (CCM) is a non-invasive, in-vivo diagnostic technique that provides an accurate surrogate biomarker for small-fiber neuropathy. In this novel study for the first time, we introduced CCM to primary care as a screening tool for DPN alongside retinopathy screening to assess the level of neuropathy in this novel cohort.Research design and methods450 consecutive subjects with type 1 or type 2 diabetes attending for annual eye screening in primary care optometry settings underwent assessment with CCM to establish the prevalence of sub-clinical diabetic peripheral neuropathy. Subjects underwent assessment for neurological and ocular symptoms of diabetes and a history of diabetic foot disease, neuropathy and diabetic retinopathy (DR).ResultsCCM examination was completed successfully in 427 (94.9%) subjects, 22% of whom had neuropathy according to Diabetic Neuropathy Symptom (DNS) score. The prevalence of sub-clinical neuropathy as defined by abnormal corneal nerve fiber length (CNFL) was 12.9%. In the subjects with a short duration of type 2 diabetes, 9.2% had abnormal CNFL. CCM showed significant abnormalities in corneal nerve parameters in this cohort of subjects with reduction of corneal nerve fiber density (CNFD, p&lt;0.001), CNFL (p&lt;0.001) and corneal nerve branch density (CNBD, p&lt;0.001) compared to healthy subjects. In subjects who had no evidence of DR (67% of all subjects), 12.0% had abnormal CNFL.ConclusionsCCM may be a sensitive biomarker for early detection and screening of DPN in primary care alongside retinopathy screening.
Contribution of mitochondrial gene variants in diabetes and diabetic kidney disease
Authors: Li Meng , Gong Siqian , Han Xueyao , Zhou Lingli , Zhang Simin , Ren Qian , Cai Xiaoling , Luo Yingying , Liu Wei , Zhu Yu , Zhou Xianghai , Li Yufeng , Ji Linong 
Published: October 2022

ObjectivesMitochondrial DNA (mtDNA) plays an important role in the pathogenesis of diabetes. Variants in mtDNA have been reported in diabetes, but studies on the whole mtDNA variants were limited. Our study aims to explore the association of whole mtDNA variants with diabetes and diabetic kidney disease (DKD).MethodsThe whole mitochondrial genome was screened by next-generation sequencing in cohort 1 consisting of 50 early-onset diabetes (EOD) patients with a maternally inherited diabetes (MID) family history. A total of 42 variants possibly associated with mitochondrial diseases were identified according to the filtering strategy. These variants were sequenced in cohort 2 consisting of 90 EOD patients with MID. The association between the clinical phenotype and these variants was analyzed. Then, these variants were genotyped in cohort 3 consisting of 1,571 type 2 diabetes mellitus patients and 496 subjects with normal glucose tolerance (NGT) to analyze the association between variants with diabetes and DKD.ResultsPatients with variants in the non-coding region had a higher percentage of obesity and levels of fasting insulin (62.1% vs. 24.6%, P = 0.001; 80.0% vs. 26.5% P &lt; 0.001). The patients with the variants in rRNA had a higher prevalence of obesity (71.4% vs. 30.3%, P = 0.007), and the patients with the variants in mitochondrial complex I had a higher percentage of the upper tertile of FINS (64.3% vs. 34.3%, P = 0.049). Among 20 homogeneous variants successfully captured, two known variants (m.A3943G, m.A10005G) associated with other mitochondrial diseases were only in the diabetic group, but not in the NGT group, which perhaps indicated its possible association with diabetes. The prevalence of DKD was significantly higher in the group with the 20 variants than those without these variants (18.7% vs. 14.6%, P = 0.049) in the participants with diabetes of cohort 3.ConclusionMtDNA variants are associated with MID and DKD, and our findings advance our understanding of mtDNA in diabetes and DKD. It will have important implications for the individual therapy of mitochondrial diabetes.
Effects of seawater and freshwater challenges on the Gh/Igf system in the saline-tolerant blackchin tilapia (Sarotherodon melanotheron)
Authors: Link Karl , Shved Natallia , Serrano Nabil , Akgül Gülfirde , Caelers Antje , Faass Oliver , Mouttet Farouhar , Raabe Oksana , D’Cotta Helena , Baroiller Jean-François , Eppler Elisabeth 
Published: October 2022

Prolactin (Prl) and growth hormone (Gh) as well as insulin-like growth factor 1 (Igf1) are involved in the physiological adaptation of fish to varying salinities. The Igfs have been also ascribed other physiological roles during development, growth, reproduction and immune regulation. However, the main emphasis in the investigation of osmoregulatory responses has been the endocrine, liver-derived Igf1 route and local regulation within the liver and osmoregulatory organs. Few studies have focused on the impact of salinity alterations on the Gh/Igf-system within the neuroendocrine and immune systems and particularly in a salinity-tolerant species, such as the blackchin tilapia Sarotherodon melanotheron. This species is tolerant to hypersalinity and saline variations, but it is confronted by severe climate changes in the Saloum inverse estuary. Here we investigated bidirectional effects of increased salinity followed by its decrease on the gene regulation of prl, gh, igf1, igf2, Gh receptor and the tumor-necrosis factor a. A mixed population of sexually mature 14-month old blackchin tilapia adapted to freshwater were first exposed to seawater for one week and then to fresh water for another week. Brain, pituitary, head kidney and spleen were excised at 4 h, 1, 2, 3 and 7 days after both exposures and revealed differential expression patterns. This investigation should give us a better understanding of the role of the Gh/Igf system within the neuroendocrine and immune organs and the impact of bidirectional saline challenges on fish osmoregulation in non-osmoregulatory organs, notably the complex orchestration of growth factors and cytokines.
Weight gain in type 1 diabetes during the SARS-CoV-2 pandemic. Does lockdown affect the metabolic control of pediatric patients?
Authors: Zubkiewicz-Kucharska Agnieszka , Wikiera Beata , Noczyńska Anna 
Published: October 2022

Background and aimsDue to the severe acute respiratory syndrome coronavirus 2 pandemic, governments of many countries decided to implement lockdowns, which included school closures. This major lifestyle change also applied to people with diabetes. The aim of this paper was to analyze how the COVID-19 pandemic and related restrictions influenced the metabolic compensation of diabetes in the pediatric population.MethodsPatients with type 1 diabetes (T1D), treated by one therapeutic team, who in 2020 and 2021 paid at least two in-person visits in the outpatient clinic, were included in the study. The time in range (TIR) and HbA1c, as well as the total daily dose (TDD) of insulin and BMI from the visit before the announcement of the pandemic restrictions (March 2020) and during the lockdown (second visit after 6 months) and within the period of loosened restrictions (two visits in 2021) were analyzed.ResultsA total of 185 patients with T1D were included in the study (96 boys), aged 2–18 years (11.5 ± 3.5); 135 of them (72.9%) use CSII and 142 (76.8%) use CGM or FGM. During the first months of the studied period, despite comparable (p&gt;0.05) TIR (57.5 ± 21.4% vs. 59.9 ± 20.5%), improvement of HbA1c was noticed (7.9 ± 1.6% vs. 7.5 ± 1.4%, p=0.0336), whereas in the following months, both HbA1c and TIR were comparable. Also, the TDD increased significantly (from 37.3 ± 18.9 units/day on the first visit up to 46.8 ± 22.7 units/day on the last visit, p=0.0003); however, TDD/kg remained constant (p&gt;0.05) (0.8 ± 0.2 units/kg/day vs. 0.8 ± 0.3 units/kg/day) possibly due to an increased BMI (19.1 ± 3.7 kg/m2vs. 20.9 ± 4.1 kg/m2, p=0.0001). The percentage of basal insulin in the TDD remained stable (p&gt;0.05) (39.7 ± 11.3% vs. 39.3 ± 13.6%). Furthermore, a significant (p=0.0001) change in the BMI percentile was noticed [from 58.9 ± 26.2 percentiles (%iles) before lockdown vs. 64.6 ± 26.0%iles on the second visit]. However, the BMI percentile returned to baseline (58.1 ± 28.4%iles) at the visit at the end of the observation period.ConclusionsThe parameters of metabolic control in pediatric patients with T1D during the pandemic period remained stable; however, weight gain and an increase in daily insulin dose have been observed, possibly due to reduced physical activity.