bluuebunny/crossref_metadata_2025_split huggingface dataset:
Statistical analysis of multi‐day solar irradiance using a threshold time series model
Authors: Euán Carolina , Sun Ying , Reich Brian J. 
Published: January 2022

AbstractThe analysis of solar irradiance has important applications in predicting solar energy production from solar power plants. Although the sun provides every day more energy than we need, the variability caused by environmental conditions affects electricity production. Recently, new statistical models have been proposed to provide stochastic simulations of high‐resolution data to downscale and forecast solar irradiance measurements. Most of the existing models are linear and highly depend on normality assumptions. However, solar irradiance shows strong nonlinearity and is only measured during the day time. Thus, we propose a new multi‐day threshold autoregressive model to quantify the variability of the daily irradiance time series. We establish the sufficient conditions for our model to be stationary, and we develop an inferential procedure to estimate the model parameters. When we apply our model to study the statistical properties of observed irradiance data in Guadeloupe island group, a French overseas region located in the Southern Caribbean Sea, we are able to characterize two states of the irradiance series. These states represent the clear‐sky and non‐clear sky regimes. Using our model, we are able to simulate irradiance series that behave similarly to the real data in mean and variability, and more accurate forecasts compared to linear models.
Retracted: Hyaluronic acid‐rich burger separator edible disc prepared from slaughterhouse waste
Authors: Kalantarmahdavi Mahboubeh , Salari Amir , Pasdar Zahra , Amiryousefi Mohamad Reza 
Published: January 2022

AbstractIn this study, the edible films from chicken feet (CF), ovine muscle fascia (MF), and bovine bone gelatin (Gel) were prepared and their characteristics were analyzed, and we also evaluated the sensory quality of raw and cooked hamburgers using the edible films. The quantities of the CF and MF hyaluronic acid were evaluated using colorimetry and spectrophotometry. The CF, MF, and Gel films were prepared by solvent casting method. Results indicated that the concentration of hyaluronic acid in CF (124.11 ppm) was greater than MF (101.11 ppm). The antioxidative property of the CF film (18.47%) was greater than the Gel (1.88%) and MF (Undetectable) film. The CF film was more resistant to water vapor permeability (2.75 × 10–9 g/m.s.pa) than the MF (1.57 × 10–8 g/m.s.pa) and Gel (1.5 × 10–7 g/m.s.pa) films. The Gel film had more appropriate mechanical properties than CF and MF films. The films kept burgers patties independent from one another and prevented them from sticking and freezing together. MF and CF films were able to promote the organoleptic properties of raw and cooked hamburgers in taste and texture.
A weight of evidence approach for bioaccumulation assessment
Authors: Arnot Jon A. , Toose Liisa , Armitage James M. , Embry Michelle , Sangion Alessandro , Hughes Lauren 
Published: January 2022

Abstract
Bioaccumulation assessments conducted by regulatory agencies worldwide use a variety of methods, types of data, metrics, and categorization criteria. Lines of evidence (LoE) for bioaccumulation assessment can include bioaccumulation metrics such as in vivo bioconcentration factor (BCF) and biomagnification factor (BMF) data measured from standardized laboratory experiments, and field (monitoring) data such as BMFs, bioaccumulation factors (BAFs), and trophic magnification factors (TMFs). In silico predictions from mass-balance models and quantitative structure-activity relationships (QSARs) and a combination of in vitro biotransformation rates and in vitro–in vivo extrapolation (IVIVE) models can also be used. The myriad bioaccumulation metrics and categorization criteria and underlying uncertainty in measured or modeled data can make decision-making challenging. A weight of evidence (WoE) approach is recommended to address uncertainty. The Bioaccumulation Assessment Tool (BAT) guides a user through the process of collecting and generating various LoE required for assessing the bioaccumulation of neutral and ionizable organic chemicals in aquatic (water-respiring) and air-breathing organisms. The BAT includes data evaluation templates (DETs) to critically evaluate the reliability of the LoE used in the assessment. The DETs were developed from standardized testing guidance. The approach used in the BAT is consistent with OECD and SETAC WoE principles and facilitates the implementation of chemical policy objectives in chemical assessment and management. The recommended methods are also iterative and tiered, providing pragmatic methods to reduce unnecessary animal testing. General concepts of the BAT are presented and case study applications of the tool for hexachlorobenzene (HCB) and β-hexachlorocyclohexane (β-HCH) are demonstrated. The BAT provides a consistent and transparent WoE framework to address uncertainty in bioaccumulation assessment and is envisaged to evolve with scientific and regulatory developments. Integr Environ Assess Manag 2023;19:1235–1253. © 2022 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
MARK2 potentiate aerobic glycolysis‐mediated cell growth in breast cancer through regulating mTOR/HIF‐1α and p53 pathways
Authors: Ponnusamy Lavanya , Natarajan Sathan Raj , Manoharan Ravi 
Published: January 2022

AbstractThe microtubule‐affinity regulating kinases (MARKs) family plays a crucial role in regulating breast cancer development and progression. However, its precise function and the relevant molecular mechanism in breast cancer have not yet been elucidated. In this study, analysis of The Cancer Genome Atlas (TCGA) data revealed that MARK2 expression was markedly upregulated in breast cancer tissues, and high expression of MARK2 was correlated with poor survival. Functional assays showed that MARK2 deletion or inhibition suppressed aerobic glycolysis and cell growth as well as induced cell cycle arrest and apoptosis in breast cancer cells. Mechanistically, MARK2 stimulates mTOR‐mediated hypoxia‐inducible factor 1 alpha (HIF‐1α) transcription activity and represses p53‐transcription activity in breast cancer cells. TCGA data revealed that MARK2 expression was positively correlated with mTOR, Raptor, S6K1, glucose transporter 1, lactate dehydrogenase, HIF‐1α, and 4E‐BP1 expression, whereas negatively correlated with p53, p21, and Bax in breast cancer tissue. Conclusively, our study demonstrated that MARK2 promotes breast cancer aerobic glycolysis and cell proliferation, and inhibits apoptosis, in part, through regulating mTOR/HIF‐1α and p53 signaling pathways. Overall, these findings point to the potential of targeting MARK2 for breast cancer treatment.
Oxygen transfer and bubble sizes occurring in a pilot‐scale cultivation of Bacillus velezensis 83 for the production of poly(γ‐glutamic acid) under two schemes of power drawn
Authors: Pulido‐Durán Nahyeli , Flores Celia , Serrano‐Carreón Leobardo , Manero Octavio , Galindo Enrique 
Published: January 2022

AbstractBACKGROUNDThe influence of power consumption on oxygen transfer during non‐Newtonian and surfactant‐producing microbial fermentations has been scarcely reported. In this work, we study the oxygen transfer and bubble size distributions in a real 100 L fermentation (producing poly(γ‐glutamic acid)) occurring under constant stirring speed (N) and under constant retrofitted power drawn (Pg/V).RESULTSFor constant N fermentations, Pg/V and the volumetric mass transfer coefficient (kLa) decreased 40% and 70% during cultivation, respectively. Fermentations at constant Pg/V showed a decrease similar to that observed for constant N fermentations. Bubble size distributions were also similar for both operational conditions. Although an increase in bubble size was expected at constant N cultivations due to the increasing viscosity of the medium, the Sauter mean diameter (d32) decreased 65%. This singular behavior of d32 was likely caused by surfactin and bacillomycin, metabolites with strong surfactant activity produced by Bacillus velezensis 83 in the cultivations. The use of a constant Pg/V did not counteract the decrease in kLa due to the increase in viscosity. Although the presence of biosurfactants leads to an increase of interfacial transfer area by decreasing d32, the presence of these molecules and the increase in the medium viscosity affected kLa.CONCLUSIONSAn atypical behavior of this system was found, especially in d32, different to that based on common correlations found in the literature. A complex interaction among the multiple factors involved in a real bioprocess for poly(γ‐glutamic acid) production was evidenced. © 2022 Society of Chemical Industry (SCI).
A Radiomic MRI based Nomogram for Prediction of Heart Failure with Preserved Ejection Fraction in Systemic Lupus Erythematosus Patients: Insights From a Three‐Center Prospective Study
Authors: Wu Lian‐Ming , Shi Ruo‐Yang , Wu Chong‐Wen , Jiang Meng , Guo Qiang , Zhu Yin‐Su , Tang Lang‐Lang , Xu Jian‐Rong , Pu Jun , Zhou Yan , Wu Rui 
Published: January 2022

BackgroundMyocardial T1 and extracellular volume (ECV) fraction values have important roles in the prognostication of heart failure with preserved ejection fraction (HFpEF). However, the traditional mean quantification of intensity levels is not sufficient.PurposeTo evaluate a T1 map‐based radiomic nomogram as a long‐term prognosticator for HFpEF in systemic lupus erythematosus (SLE) patients.Study TypeProspective.PopulationA total of 115 SLE patients and 50 age‐ and gender‐matched controls.Field Strength/SequenceA 3.0 T scanner; cine imaging, precontrast and post‐contrast T1 mapping and T2 mapping sequences.AssessmentA radiomic nomogram was developed based on precontrast T1 mapping. Three independent readers assessed and compared the ECV value and the value of the radiomic nomogram for predicting HFpEF in SLE patients.Statistical TestCox proportional hazard models, Youden index for determining cut‐off values for high HFpEF risk vs. low HFpEF risk classification, Kaplan–Meier analysis, intraclass correlation (ICC), and Uno C statistic test.ResultsDuring a median follow‐up of 27 (interquartile range, 19–37) months, 31 SLE patients developed HFpEF. Patients with elevated ECV (≥31%) and a higher output (≥42.7) from the radiomic feature “S_33_sum average” of the precontrast T1 map had a significantly higher risk of developing HFpEF than those who had lower ECV (<31%) and an output <42.7. Patients with a higher “S_33_sum average” value on precontrast T1 map had a significantly increased risk for HFpEF (hazard ratio, 1.363, 95% CI, 1.130–1.645), after adjusting for covariates including ECV and LVEF. Finally, “S_33_sum average” from precontrast T1 mapping had modest but significantly incremental prognostic value over the mean ECV value (Uno C statistic comparing models, 0.860 vs. 0.835).Data ConclusionThe precontrast T1 map‐based radiomic nomogram, as a measure of diffuse myocardial fibrosis was associated with HFpEF and provided modest prognostic value for predicting HFpEF in SLE patients.Evidence Level1Technical EfficacyStage 2
Genetic variation of E6, E7, and L1 genes of human papillomavirus 51 from central China
Authors: Ye Mengxia , Li Shuo , Luo Ping , Tang Xuan , Gong Quan , Mei Bing 
Published: January 2022

AbstractThe incidence of cervical cancer is closely related to high‐risk human papillomavirus (HR‐HPV). Women in Jingzhou had relatively high susceptibility to HPV‐51, whose ratio was 9.61% (456/4743) among HR‐HPV‐positive samples and ranked fifth in all analyzed HR‐HPV types. In this study, variations and phylogenetic trees of HPV‐51 E6−E7 and L1 sequences were analyzed by MEGA‐X. The selective pressure was estimated using PAML. The B‐cell epitope of L1 amino acid sequences and T‐cell epitope of E6 and E7 amino acid sequences were further predicted by ABCpred server and IEDB website, respectively. In the E6−E7 sequences 14 single nucleotide variants occurred, among which 4 were nonsynonymous variants and 10 were synonymous variants. A total of 41 single nucleotide variants were identified in the L1 sequences, including 10 nonsynonymous variants and 31 synonymous variants. All the isolates of both E6−E7 and L1 were classified into the A variant lineage. In HPV‐51 E6−E7 and L1 sequences, no positively selected site was found. Two nonconservative substitutions, H119Y and N176S in L1, affected multiple hypothetical B‐cell epitopes. Three nonconservative substitutions, T86P, S100L in E6, and F29L in E7, affected multiple hypothetical T‐cell epitopes. Elucidation of the HR‐HPV prevalence characteristics and genetic variations of HPV‐51 in central China may contribute to future investigations of diagnostic probes, therapeutic or preventative vaccines with wider coverage.
Transmission dynamics and mutational prevalence of the novel Severe acute respiratory syndrome coronavirus‐2 Omicron Variant of Concern
Authors: Saxena Shailendra K. , Kumar Swatantra , Ansari Saniya , Paweska Janusz T. , Maurya Vimal K. , Tripathi Anil K. , Abdel‐Moneim Ahmed S. 
Published: January 2022

AbstractThe novel Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) variant, Omicron (PANGO lineage B.1.1.529) is being reported from all around the world. The WHO has categorized Omicron as a Variant of Concern (VOC) considering its higher transmissibility and infectivity, vaccine breakthrough cases. As of January 6, 2022, Omicron has been reported in at least 149 countries. Therefore, this study was planned to investigate the transmission dynamics and mutational prevalence of the novel SARS‐CoV‐2 Omicron variant. The transmission dynamics and Omicron SARS‐CoV‐2 divergence was studied using GISAID and Nextstrain which provides information about the genetic sequences, epidemiological, geographical, and species‐specific data of human, avian, and animal viruses. Further, the mutation prevalence in spike glycoprotein of Omicron was studied, and the frequency of the crucial mutations was compared with the other prevalent VOCs. The transmission dynamics suggest that the Omicron was first identified in South Africa and then it was reported in the United Kingdom followed by the United States and Australia. Further, our phylogenetic analysis suggests that Omicron (BA.1) was clustered distinctly from the other VOCs. In the Spike glycoprotein, the Omicron (B.1.1.529) demonstrates critical 32 amino acid changes. This study may help us to understand mutational hotspots, transmission dynamics, phylogenetic divergence, effect on testing and immunity, which shall promote the progress of the clinical application and basic research.
Fungi as veritable tool in bioremediation of polycyclic aromatic hydrocarbons‐polluted wastewater
Authors: Alao Micheal B. , Adebayo Elijah A. 
Published: January 2022

AbstractPolycyclic aromatic hydrocarbons of diverse forms have found application in different industries and man heavily depends on these compounds for various purposes. Thus, tonnes of thousands of polycyclic aromatic hydrocarbons are released into various water bodies yearly, resulting in pollution with great effects on aquatic lives, man, and the ecosystem at large. Hydrocarbon pollutions in wastewater are remediated by some physical and chemical methods with most of these techniques leaving a different form of harmful byproducts after the remediation. Furthermore, several species of fungi are important in the microbial bioremediation of polycyclic aromatic hydrocarbon in wastewater as they are capable of using these compounds as their source of carbon and energy in the presence of oxygenase. Fungal bioremediation is cost‐effective, safer, and ecologically friendly, in addition to fungi producing polycyclic aromatic hydrocarbon degradative enzymes in high amounts, both intracellularly and extracellularly. Although optimizing the growth requirement of fungi in the field is a major challenge, current advances in the application of fungi in bioremediation address this. This review discusses in detail the technology of fungal bioremediation of polycyclic aromatic hydrocarbon in wastewater and its beneficial roles to man and the ecosystem. The benefits of remediating polycyclic aromatic hydrocarbon‐polluted water with fungi and their metabolites via nanotechnology, immobilization, genomic manipulation, and other technologies to generate value‐added products are highlighted in this manuscript. Information in this review will provide useful important insights to researchers and industrial professionals in the bioremediation of polycyclic aromatic hydrocarbon.
Prognostic factors of overall survival in patients with recurrent disease following liver resection for colorectal cancer metastases: A multicenter external validation study
Authors: Park Lily J. , Daza Julian F. , Li Vivian , Workneh Aklile , Zuk Victoria , Claasen Marco P. A. , Hallet Julie , Martel Guillaume , Sapisochin Gonzalo , Serrano Pablo E. 
Published: January 2022

AbstractBackgroundThe clinical course of patients experiencing recurrence following hepatectomy for colorectal cancer metastases (CRM) is poorly defined. Previous studies associated shorter time to recurrence (TTR) in months, node‐positive primary tumor, and more than one site of recurrence with worse outcomes.MethodsWe conducted a retrospective cohort study across four Canadian institutions to externally validate previously established prognostic factors of overall survival (OS). We included consecutive adult patients who had a recurrence following curative‐intent liver resection for CRM. Prognostic factors were explored using a multivariable Cox regression model. Risk group cutoffs were identified through recursive partitioning. OS between low‐ and high‐risk groups was compared using the Kaplan–Meier method.ResultsThis study included 471 patients. Shorter TTR in months (hazard ratio [HR]: 0.95, 95% confidence interval [CI]: 0.93–0.97), presence of extrahepatic disease at first hepatectomy (HR: 2.54, 95% CI: 1.18–5.50), and larger tumor size in millimetres (HR: 1.01, 95% CI: 1.00–1.02) were associated with worse OS. Median OS in the high‐ and low‐risk groups were 40.5 (95% CI: 34.0–45.7 months) versus 64.7 months (95% CI: 57.9–72.3 months; p < 0.001), respectively.ConclusionsWe externally validated the prognostic significance of shorter TTR (<8.5 months) as a predictor of worse OS in patients who recur the following hepatectomy for CRM.
Same‐day mastectomy and axillary lymph node dissection is safe for most patients with breast cancer
Authors: Tamminen Anselm , Meretoja Tuomo , Koskivuo Ilkka 
Published: January 2022

AbstractBackground and ObjectiveThe aim of this study was to evaluate the safety of same‐day mastectomy, with or without a sentinel node biopsy (SNB) and/or axillary lymph node dissection (ALND).MethodsIn this retrospective study, we reviewed 913 consecutive women who underwent a simple mastectomy for breast cancer between the years 2014 and 2019 and were treated either with same‐day surgery (SDS) or an overnight stay (OS) regime. We reviewed all surgical complications, any unplanned return to care (RTC) and the rehospitalization rate for 30 postoperative days.ResultsA total of 259 patients (28%) were treated with SDS and 654 patients (72%) with an OS regime. There was no difference in RTC (odds ratio: 0.79 [95% confidence interval: 0.53–1.18], p = 0.26) or any major complications between the groups. None of the investigated subgroups, such as patients with previous neoadjuvant therapy, diabetes, obesity (up to a body mass index of 40 kg/m2), the American Society of Anaesthesiologist Class of 3, or elderly patients aged 75–84 years, showed an increased complication rate when treated with the SDS regime.ConclusionA same‐day simple mastectomy is safe with SNB and/or ALND. It can be performed safely for most patients with stable co‐morbidities.
Intensive care unit observation after pancreatectomy: Treating the patient or the surgeon?
Authors: Sutton Thomas L. , Potter Kristin C. , O'Grady Jack , Aziz Michael , Mayo Skye C. , Pommier Rodney , Gilbert Erin W. , Rocha Flavio , Sheppard Brett C. 
Published: January 2022

AbstractBackgroundRoutine intensive care unit admission (ICUA) is commonplace following pancreatectomy, particularly pancreaticoduodenectomy. The value of this practice in avoiding failure‐to‐rescue is poorly studied.MethodsWe queried our institutional National Surgical Quality Improvement Project database for patients undergoing pancreatectomy from 2013 to 2020. Postoperative dispositions, ICU courses, and hospital cost data in United States Dollars (USD) were captured. Data were analyzed with multivariable logistic regression.ResultsSix‐hundred‐thirty‐seven patients were identified; 404 (63%) underwent pancreaticoduodenectomy. Postoperatively, 398 (99%) pancreaticoduodenectomies and 110 (47%) distal pancreatectomies had ICUA; two‐thirds (n = 318, 63%) did not require immediate postoperative ICU‐level interventions at ICUA. Of these, 17 (5.3%) subsequently required ICU‐level interventions during initial ICUA, most commonly antiarrhythmic infusion (n = 12). Thirty‐day and 90‐day mortality in patients requiring immediate ICU‐level interventions was 5% (n = 10) and 8% (n = 16) versus 0.3% (n = 1) and 1.2% (n = 4) in those without, respectively. Hospital length of stay was significantly longer with initial ICU‐level interventions (median 11 vs. 9 days, p < 0.001), as were total ICU costs (mean 8683 vs. 14611 USD, p < 0.001).ConclusionAt high‐volume pancreas centers, patients without immediate postoperative ICU‐level interventions are very low risk for failure‐to‐rescue. Ward admission with a low threshold for care escalation presents a significant opportunity for cost‐savings and un‐burdening ICUs.
Chemical profiling and quantification of multiple components in Jin‐Gu‐Lian capsule using a multivariate data processing approach based on UHPLC‐Orbitrap Exploris 240 MS and UHPLC‐MS/MS
Authors: Zhou Zu‐Ying , Huang Yong , Xiao Jin‐Chao , Liu Hui , Wang Yong‐Lin , Gong Zi‐Peng , Li Yue‐Ting , Wang Ai‐Min , Li Yong‐Jun , Zheng Lin 
Published: January 2022

AbstractThe Jin‐Gu‐Lian capsule, a Chinese Miao herbal compound, is widely used to treat rheumatoid arthritis. In this study, a rapid, selective, and sensitive UHPLC‐Orbitrap Exploris 240 MS method was developed to analyze the chemical composition of Jin‐Gu‐Lian capsules. A total of 88 compounds were identified, including 23 flavonoids, 23 organic acids, 14 phenylpropanoids, 12 phenols, eight alkaloids, four terpenes, three quinones, and one ketone. Among these, 21 compounds were clearly detected based on a comparison with reference standards and selected as quality control markers. Thereafter, these compounds were simultaneously determined in the Jin‐Gu‐Lian capsules. The established method was successfully validated and applied for the simultaneous determination of 21 biologically active compounds in Jin‐Gu‐Lian capsules of 27 sample batches. Quantitative data of the analytes were analyzed using multivariate statistical analysis to determine the quality of the Jin‐Gu‐Lian capsules. Four compounds (JGLC6 [salidroside], JGLC8 [chlorogenic acid], JGLC12 [liriodendrin], JGLC19 [quercetin]) were identified as chemical markers for quality control of Jin‐Gu‐Lian capsules. Altogether, the established method was validated as a novel and efficient tool, that can be used for rapid analysis of Jin‐Gu‐Lian capsules. Accordingly, this study serves as a reference for scientific research on traditional Chinese and ethnic medicine.