bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevention of epicardial coronary artery spasm with intracoronary nitroglycerine during acetylcholine testing in a female patient with resting angina—implications for optimal pharmacological management
Authors: Martínez Pereyra Valeria , Seitz Andreas , Sechtem Udo , Ong Peter 
Published: March 2022

AbstractWe here present the case of a 55‐year old woman who presented with recurrent angina at rest followed by presyncopal attacks and nausea to our clinic. Her only cardiovascular risk factor was arterial hypertension. High‐sensitive troponin T was 3 pg/ml (n < 14 pg/ml) and the 12‐lead resting ECG was unremarkable. Differential diagnoses included stenosing coronary artery disease and coronary artery spasm. Thus, invasive coronary angiography was performed showing unobstructed coronary arteries. Acetylcholine (ACh) provocation testing in search of coronary spasm showed diffuse epicardial spasm of the left anterior descending coronary artery (LAD) and focal spasm of the left circumflex coronary artery (LCX), which could be resolved by intracoronary administration of 0.2 mg nitroglycerine (NTG). To evaluate the potential protective effect of NTG, ACh provocation testing was repeated after NTG injection. This rechallenge showed no more epicardial spasm, suggesting that NTG had a protective antispastic effect on the epicardial arteries in this patient. Symptom control in patients with angina due to coronary artery spasm can be challenging as pharmacological agents are often prescribed on a trial and error basis. With this case, we present a novel approach toward a more individualized pharmacotherapy in coronary artery spasm using a modified protocol for invasive coronary spasm testing, which could avoid ineffective treatment trials in such patients.
Crimean‐Congo hemorrhagic fever in the COVID‐19 pandemic: A case study
Authors: Mardani Masoud , Aghazadeh Sarhangipour Kouros , Nikpour Shahriar , Hakamifard Atousa 
Published: March 2022

AbstractIn the COVID‐19 pandemic, the overlap of clinical features between other viral infections makes a reliable diagnosis difficult in the initial stage of illness. We describe a confirmed case of CCHF in Tehran Province during this year, who was first misdiagnosed as COVID‐19 infection.
A variant of Takotsubo syndrome concomitant with left atrial myxoma
Authors: Ishibashi Naoki , Nagai Michiaki , Dote Keigo , Kato Masaya , Oda Noboru , Tachibana Hitoshi , Katayama Akira 
Published: March 2022

AbstractWe treated an 80‐year‐old Japanese woman who had Takotsubo syndrome (TTS) concomitant with a left atrial (LA) tumor. Left ventriculography revealed a variant of TTS. In cardiac surgery, the LA mass was successfully resected without embolism, with the pathological diagnosis of myxoma.
Lipodystrophy: Still an underdiagnosed complication of subcutaneous insulin administration
Authors: Barbosa Mariana , Silva Ana Sara , Fernandes Vera 
Published: March 2022

AbstractLipodystrophy is a common but often underdiagnosed complication of subcutaneous insulin injections. We present an illustrative case, aiming to remind physicians to consider lipodystrophy when evaluating a patient under insulin therapy with otherwise unexplained metabolic decompensation. A complete physical examination and patient education are crucial in this setting.
Progressive compression and weight reinforcement for spiking neural networks
Authors: Elbez Hammouda , Kamel Benhaoua Mohammed , Devienne Philippe , Boulet Pierre 
Published: March 2022

SummaryNeuromorphic architectures are one of the most promising architectures to reduce the energy consumption of tomorrow's computers. These architectures are inspired by the behavior of the brain at a fairly precise level and consist of artificial spiking neural networks. To optimize the implementation of these architectures, we propose in this article a novel progressive network compression and reinforcement technique. This technique consists of two functions: progressive pruning and dynamic synaptic weight reinforcement, which we apply after each training batch. The proposed approach delivers a highly compressed network (up to 80% of compression rate) while preserving the network performance when tested with MNIST.
Ethyl Zinc β‐Ketoiminates and β‐Amidoenoates: Influence of Precursor Design on the Properties of Highly Conductive Zinc Oxide Thin Films from Aerosol‐Assisted Chemical Vapour Deposition.
Authors: Bhide Malavika A. , Carmalt Claire J. , Knapp Caroline E. 
Published: March 2022

AbstractHighly transparent (>85 %) and conductive (1.086×10−3 Ω cm) zinc oxide thin films have been deposited from specifically selected precursors allowing us to establish a direct correlation between their molecular structure and the optoelectronic properties of the deposited films. Mono‐ligated ethyl zinc compounds of varying steric bulk: [EtZn(OC(Me)CH(Me)N(iPr))]2 (1), [EtZn(OC(OEt)CH(Me)N(iPr))]2 (2) and [EtZn(OC(OEt)CH(CH3)N(Dipp))]2 (3) were compared with the related bis‐ligated zinc complexes [Zn(OC(Me)CH(Me)N(iPr))2] (4), [Zn(OC(OEt)CH(Me)N(iPr))2] (5) and [Zn(OC(OEt)CH(Me)N(Dipp))2] (6). In all cases bulkier ligands resulted in poorer electronic properties of deposited films, whilst all mono‐ligated compounds were shown as superior precursors. All complexes were characterised by 1H and 13C{1H} NMR and elemental analysis, with the structure of 6 determined by single crystal X‐ray diffraction. Zinc oxide films were deposited from single and dual source (with methanol) reactions of these precursors, and analysed via XRD, XPS and EDX. Optoelectronic properties were investigated through UV/vis spectroscopy and Hall effect measurements, and morphology was examined via SEM. Tauc plots from UV/vis data indicated that Film A showed the lowest band gap of 3.31 eV. Varying the elemental composition of the precursors led to changes in the elemental composition of the resultant films, as well as changes in their structural and optoelectronic properties. Using this approach of precursor design, we have been able to tune single source precursors towards zinc oxide to deposit films with specific properties.
Photovoltaic‐based grid‐connected transformer‐less three‐phase cascaded diode‐clamped multilevel inverter with reduced leakage current
Authors: Rao Pandry Narendra , Saini Lalit Mohan 
Published: March 2022

AbstractA photovoltaic (PV) transformer‐less grid‐connected cascaded diode‐clamped half‐bridge multilevel inverter (MLI) is presented in this paper. Compared with the conventional cascaded H‐bridge (CHB) multilevel inverter, the projected inverter permits connection of double the DC‐link voltage and hence enhances its rating. The most common problem the PV‐based transformer‐less grid‐connected CHB MLI system faces is the flow of leakage currents created by parasitic capacitances due to the disparity in common‐mode voltage. As per the German standards VDE‐V‐0126‐1‐1, the leakage current must be less than 30 mA. In the proposed inverter, due to the high‐frequency pulse width modulation of voltage, a peak leakage current flow of nearly 300 mA at switching frequency (2500 Hz) and about 150 mA at its subsequent harmonics is observed. Therefore, LC‐filters are employed in the proposed inverter to suppress the peak leakage currents to less than 3 mA. Also, the LC‐filters improve the total harmonic distortion (THD) profile of the injected grid current. Further, the proposed inverter is also designed to address the temporary faults. The proposed transformer‐less inverter is simulated using the MatLab/Simulink platform, and the results are experimentally validated by performing on a real‐time hardware‐in‐the‐loop using OPAL‐RT OP5700 digital simulator as plant and dSPACE 1202 as controller.
Probabilistic classification of anti‐SARS‐CoV‐2 antibody responses improves seroprevalence estimates
Authors: Castro Dopico Xaquin , Muschiol Sandra , Grinberg Nastasiya F , Aleman Soo , Sheward Daniel J , Hanke Leo , Ahl Marcus , Vikström Linnea , Forsell Mattias , Coquet Jonathan M , McInerney Gerald , Dillner Joakim , Bogdanovic Gordana , Murrell Ben , Albert Jan , Wallace Chris , Karlsson Hedestam Gunilla B 
Published: March 2022

AbstractObjectivesPopulation‐level measures of seropositivity are critical for understanding the epidemiology of an emerging pathogen, yet most antibody tests apply a strict cutoff for seropositivity that is not learnt in a data‐driven manner, leading to uncertainty when classifying low‐titer responses. To improve upon this, we evaluated cutoff‐independent methods for their ability to assign likelihood of SARS‐CoV‐2 seropositivity to individual samples.MethodsUsing robust ELISAs based on SARS‐CoV‐2 spike (S) and the receptor‐binding domain (RBD), we profiled antibody responses in a group of SARS‐CoV‐2 PCR+ individuals (n = 138). Using these data, we trained probabilistic learners to assign likelihood of seropositivity to test samples of unknown serostatus (n = 5100), identifying a support vector machines‐linear discriminant analysis learner (SVM‐LDA) suited for this purpose.ResultsIn the training data from confirmed ancestral SARS‐CoV‐2 infections, 99% of participants had detectable anti‐S and ‐RBD IgG in the circulation, with titers differing > 1000‐fold between persons. In data of otherwise healthy individuals, 7.2% (n = 367) of samples were of uncertain serostatus, with values in the range of 3‐6SD from the mean of pre‐pandemic negative controls (n = 595). In contrast, SVM‐LDA classified 6.4% (n = 328) of test samples as having a high likelihood (> 99% chance) of past infection, 4.5% (n = 230) to have a 50–99% likelihood, and 4.0% (n = 203) to have a 10–49% likelihood. As different probabilistic approaches were more consistent with each other than conventional SD‐based methods, such tools allow for more statistically‐sound seropositivity estimates in large cohorts.ConclusionProbabilistic antibody testing frameworks can improve seropositivity estimates in populations with large titer variability.
Morphology analysis of unlabeled red blood cells based on quantitative differential phase contrast microscopy
Authors: He Linna , Shao Meng , Yang Xiao , Si Li , Jiang Mengduo , Wang Tao , Ke Zeyu , Peng Tao , Fang Shu , Zhang Shengzhao , Ouyang Xilin , Zhao Gang , Zhou Jinhua 
Published: March 2022

AbstractThe current classical blood smear technique to observe the morphology of single red blood cells (RBCs) for classification is a laborious and error‐prone process. To objectively evaluate the morphology of blood cells, we established a method of computational imaging based on a programmable light emitting diode array. By using quantitative differential phase contrast (qDPC), we characterized the morphology of unlabeled RBCs as well as blood smears. By focusing on comparing the difference of imaging between unlabeled RBCs and stained RBCs under multimode microscopic imaging technology, we demonstrated that qDPC could clearly differentiate discocytes and spherocytes in both unlabeled RBCs and blood smears. The phase map provided by quantitative phase imaging further enhanced the classification accuracy. According to statistical analysis from morphological indexes, the qDPC imaging has a significantly improvement in non‐circularity, texture inhomogeneity and equivalent diameters of cells. Thus, this method has a significant superiority in the capability to analyze the morphology of RBCs and could be applied to clinical assays for determining morphological, functional, and structural deterioration of RBCs.
Vanet‐TSMA: A traffic safety management approach for smart road transportation in vehicular ad hoc networks
Authors: Kaul Ajay , Altaf Insha 
Published: March 2022

SummaryOver the past two decades, vehicular collisions have been a significant concern for governments, researchers, and automobile manufacturers. However, collisions are unexpected and occur regularly on roads, resulting in deaths, infrastructure destruction, and health injuries. As a result, it is essential to avoid, prevent, and detect traffic collisions at the highest degree possible for minimizing human loss. In this article, the trend of road traffic accidents in India has been analyzed graphically. Towards the end, a VANET‐based traffic safety management approach (VANET‐TSMA) has been proposed to reduce road accidents in India. This approach uses message distribution, traffic management, and congestion control efficiently for reducing the overall rate of road accidents. This method is based on multiple information and communication technology (ICT)‐based safety mechanisms which include collision avoidance, collision detection, and traffic congestion avoidance for the protection of future connected automobiles on roads.
Development of dynamic wireless power transfer system for vehicle logistics robot
Authors: Shimizu Osamu , Hanabusa Kazuyoshi , Arasaki Kota , Gunji Daisuke , Sakai Yuto , Ikeda Hiromori , Matsuoka Fuminori 
Published: March 2022

AbstractLaborsaving is a major issue in production. In an automotive production line, a yard that is used as a temporary storage for vehicles before shipping. The vehicle‐loading robot that operates autonomously has been proposed to automate the alignment of vehicles in the yard instead of human driving. In this study, the dynamic wireless power transfer (DWPT) system that includes the structure of the roadside for the vehicle‐loaded robot is proposed. It is proven that the transmitter coil has enough durability for the load of the robot weight using simulation and actual measurement. It is also shown that the reinforcement bars of the road structure cause considerable eddy current loss even with stainless steel. This is similar to loss by coil resistance. This system achieves a 1.8 kW DWPT with an automated coil detection system and a frequency control system, under factory conditions.
Fluid friction/heat transfer irreversibility and heat function study on MHD free convection within the MWCNT–water nanofluid‐filled porous cavity
Authors: Kumar Alagarsamy Vanav , Lawrence Jino , Saravanakumar G. 
Published: March 2022

AbstractThe study comprises the effect of natural/free convection on an MWCNT–water nanofluid‐filled cavity. The porous cavity is heated/cooled to the left/right walls and the horizontal wall is maintained adiabatically. The flow behavior and entropy analysis are evaluated numerically using the finite difference approximation techniques. This study is bounded with various dimensional parameters such as —nanoparticle concentration, Ha—Hartmann number, Ra—Rayleigh number, and Da—Darcy number. The results of the study are illustrated using —streamlines or stream function, —isotherms, —heatlines or heat function, —fluid friction irreversibility, —heat transfer irreversibility, —cup‐mixing temperature, and —root‐mean‐square deviation. Also, —average Nusselt number and —average Bejan number are used to represent the transfer rate of heat and irreversibility of fluid friction/heat transfer, respectively. The domination of conduction on lower Ra and Da are noticed and, domination of convection on higher Ra and Da are observed using a heatline map. The fluid friction and heat transfer irreversibilities are highly noted near the vertical boundaries for increasing Rayleigh number and Darcy number.
Selective inhibitors of bromodomain BD1 and BD2 of BET proteins modulate radiation‐induced profibrotic fibroblast responses
Authors: Liu Chun‐Shan , Rioja Inmaculada , Bakr Ali , Veldwijk Marlon R. , Sperk Elena , Herskind Carsten , Weichenhan Dieter , Prinjha Rab K. , Plass Christoph , Schmezer Peter , Popanda Odilia 
Published: March 2022

AbstractRadiotherapy can induce various adverse effects including fibrosis in cancer patients. Radiation‐induced aberrant expression of profibrotic genes has been associated with dysregulated epigenetic mechanisms. Pan‐BET (bromodomain and extraterminal domain) inhibitors, such as JQ1 and I‐BET151, have been reported to attenuate the profibrotic response after irradiation. Despite their profound preclinical efficacy, the clinical utility of pan‐inhibitors is limited due to observed cytotoxicicities. Recently, inhibitors were developed that selectively target the first (BD1) and second (BD2) bromodomain of the BET proteins (iBET‐BD1 [GSK778] and iBET‐BD2 [GSK046]). Here, their potential to attenuate radiation‐induced fibroblast activation with low‐toxicity was investigated. Our results indicated that cell proliferation and cell cycle progression in fibroblasts from BJ cells and six donors were reduced when treated with I‐BET151 and iBET‐BD1, but not with iBET‐BD2. After irradiation, induction of DGKA and profibrotic markers, especially COL1A1 and ACTA2, was attenuated with all BET inhibitors. H3K27ac enrichment was similar at the DGKA enhancer region after I‐BET151 treatment and irradiation, but was reduced at the COL1A1 transcription start site and the ACTA2 enhancer site. iBET‐BD2 did not change H3K27ac levels in these regions. BRD4 occupancy at these regions was not altered by any of the compounds. Cell migration activity was measured as a characteristic independent of extracellular matrix production and was unchanged in fibroblasts after irradiation and BET inhibitor‐treatment. In conclusion, iBET‐BD2 efficiently suppressed radiation‐induced expression of DGKA and profibrotic markers without showing cytotoxicity. Thus BD2‐selective targeting is a promising new therapeutic avenue for further investigations to prevent or attenuate radiotherapy‐induced fibrosis.
Social and general anhedonia in adolescents: Stability and associations with other symptoms
Authors: Yang Xinhua , Guo Yuqi , Harrison Phillippa , Liu Xiaoqun 
Published: March 2022

AbstractIntroductionRecent works have developed two self‐report measures of general and social anhedonia for adolescents. Little is known about the relative stability of these constructs and their associations with psychopathological symptoms over time.MethodsA total of 694 Chinese adolescents aged 14–16 years (74.6% girls) completed measures of anhedonia at two time points 1 year apart. General anhedonia was assessed using the Snaith Hamilton Pleasure Scale while social anhedonia was assessed using the Adolescent Anticipatory and Consummatory Interpersonal Pleasure Scale.ResultsGeneral and social anhedonia significantly increased over time, F(1, 693) =16.54, p < .001, η2 = 0.02; F(1, 693) =27.31, p < .001, η2 = 0.04. Greater depression (b = ‐0.10, p = .006), suicidal ideation (b = ‐0.55, p < .001), generalized anxiety (b = ‐0.28, p = .012), social anxiety (b = ‐0.28, p = .002), and interpersonal stressful events (b = ‐0.20, p = .035) were associated with greater social anhedonia. Suicidal ideation was associated with general anhedonia (b = 0.29, p = .004). Higher positive schizotypal personality was associated with less general and social anhedonia (b = ‐0.18, b = 0.16, all p < .001) whereas higher negative schizotypal personality was associated with greater general and social anhedonia (b = 0.34, b = ‐0.58, all p < .001).ConclusionsThis finding suggests that anhedonia is an increasing trend during adolescence. The relationship between anhedonia and psychopathology was specific to social anhedonia.
A method to measure the uniformity of the virtual image distance in an augmented reality or virtual reality device
Authors: Hong Hyungki 
Published: March 2022

AbstractThe virtual image distance in an augmented reality (AR) or virtual reality (VR) device is an important factor in determining its performance. In this paper, a method for measuring the virtual image distance and its uniformity is proposed. The setup for measurement consists of a two‐dimensional spatial sensor array on the translational stage and a pinhole array plate placed in front of the AR or VR device. As the distance between the pinhole plate and the two‐dimensional spatial sensor array were changed, the positions of the rays through each pinhole were measured by a two‐dimensional spatial sensor array. The ray trajectories through each pinhole were obtained by fitting these positions to straight lines. The relative distances between these ray trajectories were calculated with respect to the distance from the pinhole plate. This method is effective for measuring the uniformity, such as the azimuthal dependence of the virtual image distance or the dependence of the virtual image distance on the distance from the optical axis of the VR lens.
Substitutability research for forward‐scatter meters in indoor low‐visibility environments
Authors: Zhuang Zibo , Li Jinfeng , Chan Pak Wai , Tai Hongda 
Published: March 2022

AbstractVisibility is a crucial parameter for aeronautical operations. Forward‐scatter meters are recommended to measure it because of inherent advantages. With wide use at airports, the substitutability among forward‐scatter meters is worth paying attention to, especially in low‐visibility environments. To confirm the substitutability among forward‐scatter meters, eight kinds of forward‐scatter meters were installed in an indoor atmospheric environment simulation chamber. The observed values of each of the eight forward‐scatter meters in haze and smoke low‐visibility environments were collected. By least‐squares fitting analysis and the ATE/LER zones method, in the haze, the two sets of CS125 can be substituted for each other in visibilities lower than 2000 m. PWD20 and V30 can be substituted for each other at visibilities lower than approximately 1200 m. From 1200 to 2000 m, the consistency of the two instruments is poor. In the smoke, CS125 and PWD20 display good substitutability with each other when visibility is less than 2000 m. If only focusing on visibilities less than approximately 1000 m, the VPF‐710 and V30 instruments can be substituted with each other.
Predictors of post‐hip fracture knee pain in hospitalized older adults with intertrochanteric femoral fracture
Authors: Kaizu Yoichi , Miyata Kazuhiro , Arii Hironori 
Published: March 2022

AbstractBackgroundPost‐hip fracture knee pain (PHFKP) is an important issue that contributes to reduced gait speed and prolonged hospitalization. Femoral morphology has been reported to contribute to the development of PHFKP, but an independent association has not been confirmed and clinically applicable cutoffs for predicting the development of PHFKP remain unclear.ObjectiveTo determine whether femoral morphology and knee extension range of motion limitation are independent factors in PHFKP and to determine cutoffs for predicting the development of PHFKP.DesignRetrospective chart review study.SettingConvalescent inpatient rehabilitation hospital.ParticipantsPatients in a convalescent ward after intertrochanteric femoral fracture surgery.Main Outcome MeasuresPHFKP development, radiographic femoral morphology (leg length discrepancy and neck‐shaft angle), and knee extension range of motion limitation.ResultsPHFKP developed in 36 (35%) of the 103 patients enrolled. The PHFKP group had a longer hospital stay (p = .029), greater weight (p = .031), greater knee extension range of motion limitation (p = .001), and more varus neck‐shaft angle (p < .001) compared to the non‐PHFKP group. Varus neck‐shaft angle (odds ratio, 0.85; 95% confidence interval [CI], 0.78–0.92; p < .001) and knee extension range of motion limitation (odds ratio, 1.18; 95% CI, 1.07–1.30; p = .001) were significant factors for PHFKP development. Neck‐shaft angle discrepancy and knee extension range of motion limitation demonstrated moderate accuracy in discriminating development of PHFKP according to receiver operating characteristic analysis, with cutoffs of 9.6° and 7.5°, respectively. Areas under the receiver operating characteristic curve were 0.77 (95% CI, 0.66–0.88; p < .001) for neck‐shaft angle discrepancy and 0.67 (95% CI, 0.56–0.79; p = .004) for knee extension range of motion limitation.ConclusionsVarus neck‐shaft angle and knee extension range of motion limitation were identified as independent predictors of PHFKP. The cutoff for neck‐shaft angle may be useful for predicting PHFKP development and to define an acceptable angle of fracture reduction to prevent PHFKP.