bluuebunny/crossref_metadata_2025_split huggingface dataset:
U-shaped association between serum albumin and pediatric intensive care unit mortality in critically ill children
Authors: Zhang Xuepeng , Zhang Lifan , Wei Canzheng , Feng Liwei , Yang Juqin , Zhang Geng , Lu Guoyan , Gui Xiying , Zhou Yue , Yang Kaiying , Zhou Jiangyuan , Zhou Xinle , Wang Ruoran , Chen Siyuan , Ji Yi 
Published: August 2022

IntroductionThe detailed association between albumin levels and mortality has not been studied in critically ill children. The aim of this study was to reveal an association between albumin levels in detail and mortality in critically ill children.Materials and methodsWe retrospectively collected data from children admitted to four pediatric intensive care units (PICUs) in China between January 2015 and October 2020. Restricted cubic spline curves based on logistic regression models were generated to evaluate the detailed associations between serum albumin levels and PICU mortality. Threshold effect analysis was performed using two piecewise regression models.ResultsThe study included 9,123 children. The overall mortality was 5.3%. The detailed association between serum albumin levels and the risk of mortality followed a U-shape. The risk of mortality decreased with increasing serum albumin levels (OR = 0.919; 95% CI: 0.886, 0.954) in children with serum albumin levels &lt; 43.2 g/L and increased with increasing serum albumin levels (OR = 1.174; 95% CI: 1.044, 1.316) in children with serum albumin levels ≥ 43.2 g/L.ConclusionThere was a U-shaped association between serum albumin levels and mortality in critically ill children in the PICU.
Olive oil consumption and all-cause, cardiovascular and cancer mortality in an adult mediterranean population in Spain
Authors: Torres-Collado Laura , García-de la Hera Manuela , Lopes Carla , Compañ-Gabucio Laura María , Oncina-Cánovas Alejandro , Notario-Barandiaran Leyre , González-Palacios Sandra , Vioque Jesús 
Published: August 2022

ObjectiveWe assessed the association between usual olive oil consumption (OOC) and all-cause, cardiovascular (CVD) and cancer mortality in an adult population in Spain.Materials and methodsOOC was evaluated at baseline in 1,567 participants aged 20 years and older from the Valencia Nutrition Study in Spain using validated food frequency questionnaires. During an 18-year follow-up period, 317 died, 115 due to CVD and 82 due to cancer. Cox regression models were used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (95%CI).ResultsAfter adjusting for demographic and lifestyle factors, the OOC was associated with a lower risk of all-cause, CVD and cancer mortality. Compared to the less than once per month consumption, the consumption of up to one tablespoon per day was associated with a 9% lower risk of all-cause mortality (HR: 0.91; 95%CI: 0.68-1.22) and the consumption of 2 or more tablespoons with a 31% lower risk of all-cause mortality (HR: 0.69; 95%CI: 0.50–0.93; p-trend = 0.011). The consumption of 2 or more tablespoons per day was also associated with lower risk of mortality for CVD (HR: 0.54; 95%CI: 0.32–0.91; p-trend = 0.018) and cancer (HR: 0.49, 95%CI: 0.26–0.94; p-trend = 0.019).ConclusionHigher olive oil consumption was associated with lower long-term risk of all-cause, CVD and cancer mortality in an adult Mediterranean population. The maximum benefit was observed for the consumption of two or more tablespoons per day.
Case report: Significant liver atrophy due to giant cystic pheochromocytoma
Authors: Feng Qingbo , Li Hancong , Qiu Guoteng , Cai Zhaolun , Li Jiaxin , Zeng Yong , Huang Jiwei 
Published: August 2022

IntroductionPheochromocytoma is a neuroendocrine tumor originating from chromaffin cells in the adrenal medulla. Giant pheochromocytomas with a maximum diameter of over 20 cm are particularly rare.Case presentationWe present a case of giant cystic pheochromocytoma in a 64-year-old woman who was found to have a right abdominal mass during an ultrasound examination, which is the largest pheochromocytoma ever documented in China. Meanwhile, obvious atrophy of the right lobe of the liver was found in preoperative CT and during the operation. Our literature review identified 20 cases with a diameter of over 20 cm. The average age at diagnosis was 51.7 (range 17–85), and 35% of cases did not exhibit classic symptoms.ConclusionGiant pheochromocytoma is an uncommon neoplasm. It can be discovered late due to a lack of clinical manifestations. Diagnosis is dependent on imaging recognition together with catecholamine secretion. Surgical resection is the only curative treatment for such tumors.
Genetic variants associated with steatohepatitis and liver fibrosis in HIV-infected patients with NAFLD
Authors: Busca C. , Arias P. , Sánchez-Conde M. , Rico M. , Montejano R. , Martín-Carbonero L. , Valencia E. , Moreno V. , Bernardino J. I. , Olveira A. , Abadía M. , González-García J. , Montes M. L. 
Published: August 2022

Background and aims: Nonalcoholic fatty liver disease (NAFLD) is a common cause of liver damage in people living with HIV (PLWHIV). Several studies have investigated candidate genes for susceptibility to NAFLD and to steatohepatitis. PNPLA3, TM6SF2, and MBOAT7-TMC4 have been reported to be associated with elevated ALT levels and the histologic parameters of nonalcoholic steatohepatitis and severity of fibrosis. Our objective was to analyze the relationship between PNPLA3, TM6SF2, and MBOAT7-TMC4 and steatosis, steatohepatitis, and liver fibrosis in PLWHIV with NAFLD.Method: A cohort of PLWHIV with persistently elevated aminotransferase levels and suspected NAFLD who underwent liver biopsy and determination of genetic variants was assessed at two large centers in Spain. All participants included in the current study were genotyped for rs738409 (PNPLA3), rs58542926 (TM6SF2), and rs641738 (MBOAT7-TMC4).Results: The study population comprised PLWHIV who were on stable antiretroviral therapy [7.7% women; median age, 49.3 years (44–53.4)]. The median CD4 count was 829 (650–980), 60% had metabolic syndrome, and 18.5% were diabetic. The median BMI was 28.9 (25.5–30.8). Patients with liver steatosis (any grade) vs. nonsteatosis tended to harbor the PNPLA3 G allele variant [57.6% vs. 16.7% (p = 0.09)], but not TM6SF2 or MBOAT7-TMC4 variants. However, those with steatohepatitis vs. nonsteatohepatitis significantly more frequently had the PNPLA3 G allele variant [69.4% vs. 39.1% (p &lt; 0.05)] and the MBOAT7-TMC4 A allele variant [75% vs. 42% (p &lt; 0.05)]. In our cohort, the TM6SF2 gene variant was not associated with steatosis or steatohepatitis. The PNPLA3 G allele variant was associated with steatohepatitis [OR 4.9 (1.3–18); p 0.02] and liver fibrosis [OR 4.3 (1.1–17.4); p 0.04], and the MBOAT7-TMC4 A allele variant was associated with steatohepatitis [OR 6.6 (1.6–27.6); p 0.01].Conclusion: The PNPLA3 G allele variant and MBOAT7-TMC4 A allele variant were associated with steatohepatitis and liver fibrosis in PLWHIV with persistently elevated aminotransferases and NAFLD. We recommend routine genotyping for PNPLA3 and MBOAT7-TMC4 in PLWHIV with NAFLD to identify those at higher risk of progression.
Therapeutic mechanisms of mulberry leaves in type 2 diabetes based on metabolomics
Authors: Ma Quantao , Li Yaqi , Zhao Ruixue , Tang Ziyan , Li Jialin , Chen Cong , Liu Xiaoyao , Hu Yujie , Wang Ting , Zhao Baosheng 
Published: August 2022

Background: Type 2 diabetes (T2D) is considered as one of the most significant metabolic syndromes worldwide, and the long-term use of the drugs already on the market for T2D often gives rise to some side effects. The mulberry leaf (ML), Morus alba L., has advantages in terms of its comprehensive therapeutic efficacy, which are characterized as multicomponent, multitarget, multipathway, and matching with the complex pathological mechanisms of diabetes.Methods: T2D rats were established by a high-fat diet combined with an intraperitoneal injection of streptozotocin; an evaluation of the hypoglycemic effects of the ML in combination with fasting blood glucose and other indicators, in addition to the utilization of metabolomics technology, was performed to analysis the metabolite changes in serum of rats.Results: MLs significantly reduced the fasting blood glucose of T2D rats, while improving the symptoms of polyphagia and polyuria. ML treatment altered the levels of various metabolites in the serum of T2D rats, which are involved in multiple metabolic pathways (amino acid metabolism, carbohydrate metabolism, and lipid metabolism), played a role in antioxidative stress and anti-inflammation, modulated immune and gluconeogenesis processes, and improved obesity as well as insulin resistance (IR).Conclusion: The ML contains a variety of chemical components, and metabolomic results have shown that MLs regulate multiple metabolic pathways to exert hypoglycemic effects, suggesting that MLs may have great promise in the development of new hypoglycemic drugs.
Assessment of the relationship between living alone and the risk of depression based on longitudinal studies: A systematic review and meta-analysis
Authors: Wu Daolin , Liu Fuwei , Huang Shan 
Published: August 2022

BackgroundLiving alone is one of the most common psychosocial factors that may have an impact on lifestyle management and health status. Although many previous cross-sectional studies have found that living alone increases the risk of depression. However, this risk has rarely been assessed on the basis of longitudinal studies. Therefore, we will explore this relationship on the basis of longitudinal studies.MethodsWe systematically searched Pubmed, Embase, and Cochrane databases up to May 2022. Adjusted odds ratios (ORs), and 95% confidence intervals (CIs) were pooled by a random-effects model using an inverse variance method.ResultsSeven studies (six cohort studies and one case-control study) were included in our study. A total of 123,859 without a history of psychosis individuals were included, and the proportion of females was 65.3%. We applied a random-effects model to minimize the heterogeneity. Overall, the pooled data suggest that people living alone are associated with an increased risk of depression compared to those who do not live alone (OR 1.42, 95%CI 1.19–1.70).ConclusionCompared to people who live with others, living alone increases the risk of depression. Only cross-sectional studies and a few longitudinal studies currently support this association; more high-quality studies will be required in the future to confirm this causal association.
Clinical characteristics of pediatric intussusception and predictors of bowel resection in affected patients
Authors: Wu Ting-Hsuan , Huang Go-Shine , Wu Chang-Teng , Lai Jin-Yao , Chen Chien-Chang , Hu Mei-Hua 
Published: August 2022

BackgroundSurgery is required for the treatment of intussusception when enema reduction is unsuccessful, or when the patient develops peritonitis, bowel perforation, or intestinal damage. We aimed to evaluate the clinical and laboratory parameters that may be used to predict the need for bowel resection in children with intussusception.MethodsThis observational retrospective study included children who were admitted to the pediatric emergency department with intussusception. Univariate and multivariate logistic regression models were used to evaluate factors associated with bowel resection.ResultsIn total, 584 children with intussusception were admitted to the pediatric emergency department; 129 of these children underwent surgery. Multivariate analysis revealed the following independent predictors of bowel resection for intussusception: symptoms for at least 2 days before surgery (OR = 6.863; p = 0.009), long intussusception (OR = 5.088; p = 0.014), pathological lead point (OR = 6.926; p = 0.003), and intensive care unit admission (OR = 11.777; p = 0.001) were factors independently associated with bowel resection.ConclusionSymptoms for at least 2 days before surgery, long intussusception, pathological lead, and intensive care unit admission were predictors of bowel resection in children with intussusception. These findings can be used to identify patients at high risk of needing surgery and bowel resection.
Telephone Monitoring of Isolated Patients With Suspected COVID-19 Disease in Primary Care: Prospective Cohort Study
Authors: Coronado-Vázquez Valle , Benito-Alonso Elena , Holgado-Juan Marina , Dorado-Rabaneda Maria Silvia , Bronchalo-González Cristina , Gómez-Salgado Juan 
Published: August 2022

Objective: Isolation of suspected cases of COVID-19 has been shown effective in reducing disease transmission and monitoring these patients from primary care allows to detect complications. The objective of this study is to determine the evolution of a cohort of patients with suspected COVID-19, and to analyse the factors associated with hospital admissions due to their unfavourable evolution.Methods: Prospective cohort study. A cohort of 166 patients with COVID-19 symptoms was selected and was followed-up by telephone calls during 14 days of home isolation.Results: By the end of the follow-up, a hospital admission had taken place in 14.7% of patients. The mean survival time until admission among diabetics was 12.6, 10.9 days for chronic kidney diseases, and 9.3 days in immunocompromised patients. Immunosuppression was a risk factor for admission over 50 years of age.Conclusion: Hospital admissions for suspected cases of COVID-19 are associated with diabetes, chronic kidney disease, and immunosuppression. Telephone monitoring of these patients from primary care allows for home isolation and early detection of disease complications.
Dengue Fever Responses in Dhaka City, Bangladesh: A Cross-Sectional Survey
Authors: Rahman Md. Mostafizur , Islam Abu Reza Md. Towfiqul , Khan Saadmaan Jubayer , Tanni Kamrun Nahar , Roy Tuly , Islam Md. Rakibul , Rumi Md. Alim Al Raji , Sakib Mohammed Sadman , Abdul Quader Masrur , Bhuiyan Nafee-Ul-Islam , Chisty Musabber Ali , Rahman Farzana , Alam Edris 
Published: August 2022

Objectives: This study intends to evaluate the Dhaka city residents’ individual views toward DF.Methods: A cross-sectional survey used google forms for collecting data. Python and RStudio were used for data management and analysis. Kruskal-Wallis or Mann-Whitney U test and logistic regression models were performed, where appropriate.Results: In total 1008 individuals participated in a pre-tested KAP survey. More than 20% reported being affected by DF before the survey, where they rated their current places as being moderately safe (43%). In terms of DF control, 65% had good knowledge, and 68% reported good practice, whereas they demonstrated an overall good attitude. The increased knowledge of individuals could contribute to behavioral changes regarding DF. Female residents demonstrated better DF attitudes (OR: 0.69; p &lt; 0.05) and practices (OR: 0.66; p &lt; 0.01) compared to male residents. Mixed unit residents had poor KAP levels. Educational attainment can also play an essential role in enhancing the attitude level.Conclusion: Overall, dengue surveillance activities with sufficient campaigns are required for behavioral change in Dhaka city. This information could be integrated into other DF-affected countries’ strategies against dengue outbreaks.
Creating efficient accounting for construction organizations utilizing key performance indicators
Authors: Aleksandrovich-Adamenko Aleksandr , Viktorovna-Koneva Marina 
Published: August 2022

In the prevailing era, the pace and effectiveness of management decisions hugely depend on the pace of processing, collection, transmission, and analysis of data regarding financial outcomes shaped by the analytical and accounting system of organizations. It seems incredibly challenging to evaluate the duty and performance of the accounting unit. However, a means of properly-built key performance indicators (KPI) comes to the aid. The duty of KPI is to make life simpler for the managers of the organization, the business owners, and regular workers. This study aims to analyze the forming of efficient accounting for construction organizations utilizing key performance indicators (KPI). To that end, theoretical, empirical, monographic, statistical and economic, logical, and abstract approaches are utilized. Based on the results, KPI is regarded as the mathematical relation of the outcomes of the approaches and techniques of its implementation and also the quantity and quality of resources utilized. Considering calculating the dependence, one can perceive how close we are to attaining a specific aim and if we are heading toward the right trajectory.
Aplikasi Aplikasi Pembelajaran Pengenalan Struktur Tumbuhan untuk Anak Usia Dini menggunakan Augmented Reality
Authors: Pratiwi Adinda Putriani , Riyanto Joko 
Published: August 2022

Pemanfaatan Teknologi Informasi (TI) dalam proses penyampaian informasi mengalami perkembangan pesat. Saat ini, teknologi terbaru yang digunakan dalam penyampaian informasi adalah teknologi Augmented Reality (AR). Pada teknologi AR, pengguna dapat menvisualisasikan objek dalam bentuk 3 dimensi. AR memiliki kelebihan bersifat interaktif dan real time sehingga AR banyak diimplementasikan di berbagai bidang. Di dunia pendidikan, AR digunakan sebagai media untuk mengenalkan struktur dan fungsi tumbuhan, terlebih mengenai mata pelajaran IPA yang terkesan susah dipahami di kalangan para pelajar. Media pembelajaran Augmented Reality Struktur dan Fungsi Tumbuhan dibuat melalui android menggunakan Unity 3D dengan Vuforia, dan menggunakan bahasa pemrograman C#, serta untuk design tampilan aplikasi menggunakan software 3D Studio Max. Dan untuk metode pengembangan perangkat lunak yang digunakan adalah waterfall. Untuk pengujian aplikasi yang dilakukan menggunakan Blackbox. Hasil dari penelitian ini adalah menjadikan proses belajar-mengajar peserta didik lebih interaktif dan inovatif.
Plant Structure Introduction Learning Application for Early Childhood using Augmented Reality
Abstract: Utilization of Information Technology (IT) in the process of delivering information has developed rapidly. Currently, the latest technology used in the delivery of information is Augmented Reality (AR) technology. In AR technology, users can visualize objects in 3-dimensional form. AR has the advantage of being interactive and real time so that AR is widely implemented in various fields. In the world of education, AR is used as a medium to introduce the structure and function of plants, especially regarding science subjects which seem difficult to understand among students. Learning media for Augmented Reality Structure and Function of Plants is made using Android using Unity 3D with Vuforia, and using the C# programming language, as well as for application display design using 3D Studio Max software. And for the software development method used is the waterfall. For application testing carried out using Blackbox. The result of this research is to make the teaching and learning process of students more interactive and innovative.
Keywords: Augmented Reality, Plant Structure and Function, Unity 3D, Vuforia, Waterfall.
Penerapan Augmented Reality Sebagai Media Pembelajaran Pengenalan Ilmu Tajwid Berbasis Android
Authors: Sari Linda 
Published: August 2022

Augmented Reality sesuai digunakan untuk membuat media pembelajaran yang menarik. Ada pun tujuan dari penelitian ini adalah membuat media pembelajaran Ilmu Tajwid bisa terbuat dengan menggunakan teknologi Augmented Reality yang diditerapkan ke dalam fitur mobile Android. Tujuan pembuatan media pembelajaran ini adalah untuk meningkatkan mutu ketaqwaan pada Allak SWT, mewujudkan tanggung jawab seseorang mukmin kepada Al-Quran, membawakan seseorang mukmin membaca Al-Quran dengan ber-Tajwid, menolong warga pemeluk mukmin berlatih Ilmu Tajwid tanpa wajib menghadiri kursus serta dapat berlatih dimanapun serta kapanpun. Kesimpulan dari penelitian ini adalah dengan memakainya aplikasi AR pengguna lebih menguasai Ilmu Tajwid tanpa terikat durasi waktu serta tempat, dan pengguna lebih atensi serta terpikat dalam berlatih Ilmu Tajwid.
Applying an Augmented Reality as an Android-Based Tajweed Science Learning Media
Abstract: Augmented Reality is suitable to be used to create interesting learning media. The purpose of this research is to make Tajweed Science learning media can be made using Augmented Reality technology which is applied to Android mobile features. The purpose of making this learning media is to improve the quality of piety to Allah SWT, realize the responsibility of a believer to the Al-Quran, bring a believer to read the Qur'an with Tajweed, help believers practice Tajweed without having to attend courses and can practice wherever and whenever. The conclusion of this study is that by using the AR application, users are more familiar with Tajweed Science without being bound by the duration of time and place, and users are more attentive and captivated in practicing Tajweed Science.
Keywords: Augmented Reality, Learning Media, Tajweed.
Applying an Augmented Reality as an Android-Based Tajweed Science Introduction Media
Abstract: The Tajweed Science upgrading tool can be made using Augmented Reality technology which is applied to Android mobile features. The purpose of this research is to improve the quality of piety to Allah SWT, to realize the responsibility of a believer to the Qur'an, to bring a believer to read the Qur'an with Tajweed, to help believers practice Tajweed without having to attend courses and to be able to practice anywhere and anytime. The conclusion of this study is that by using the AR application, users are more familiar with Tajweed Science without being bound by the duration of time and place, and users are more attentive and captivated in practicing Tajweed Science.
Keywords: Augmented Reality, Learning Media, Tajweed.
ACCUMULATION OF LEAD AND CADMIUM IN TISSUES OF CYPRINUS CARPIO COLLECTED FROM CAGES OF AL-GHARRAF RIVER /THI QAR / IRAQ
Authors: Al-Aboudi H. J. , Al-Rudainy A. J. , Maktoof A. Abid Maktoof 
Published: August 2022

This study was aimed to investigate the lead and cadmium in water and in fish samples collected from three sites of Gharraf River at Thi Qar from September 2020 until April 2021. Results showed that (Pb) in river water ranged 0.156 - 4.306µg/l and the (Cd) 0.074 - 0.523 µg/l which recorded a significant differences among all sites as well as among all seasons. In addition the concentrations of Pb in some tissues of Cyprinus carpio ranged 0.069 - 4.98µg/g in muscles and kidney respectively, while Cd ranged 0.038 - 1.46 µg/g in muscles and kidney respectively. The study also showed a significant differences in Pb concentrations in fish tissues among all sites during seasons and recorded a significant differences in the summer compared with other season for Pb and Cd. A significant difference was also found in Pb and Cd concentrations between cages fish and the wild fishes for all seasons. The study proved that the water of the Al-Gharraf River is of low toxicity and less than the Iraqi and international standards, and the accumulation of Pb and Cd in the muscles of fish was less than the limits of the Federal Agency for Environmental Protection and the World Health Organization.
Deep learning-based vehicular channel estimator in high mobility environments
Authors: Abderrahim Mountaciri 
Published: August 2022

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