bluuebunny/crossref_metadata_2025_split huggingface dataset:
Senescent macrophages alter fibroblast fibrogenesis in response to SARS-CoV-2 infection
Authors: Pence Brandt , Zhang Yufeng , Antwi Ivy , Cory Theodore James 
Published: August 2022

Abstract
SARS-CoV-2 has, since its emergence in 2019, become a global pandemic. Disease outcomes are worsened in older patients who are infected. The causes for this is multifactorial, but one potential cause for this disparity is increased rates of cellular senescence in older individuals, particularly in immune cells. Cellular senescence, the accumulation of factors resulting in cell growth arrest and apoptosis resistance, increases as individuals age. In immune cells, senescence is associated with increased inflammation, and alterations in immune response. We utilized a co-culture system consisting of senescent or non-senescent macrophages directly cultured with fibroblasts, and infected with SARS-CoV-2. We assessed the expression of collagen and fibronectin, important molecules in the extracellular matrix, as well as a number of fibrogenic factors. We observed that infection with SARS-CoV-2 induced collagen production in co-cultures with senescent, but not non-senescent macrophages. Fibronectin expression was decreased in both co-culture conditions. While significant results were not observed, concentrations of other fibrogenic molecules were consistent with the collagen results. These data demonstrate that senescence in macrophages alters the production of fibrotic molecules from fibroblasts in a SARS-CoV-2 infection model. As collagen and fibronectin expression are generally directly correlated, this suggests that senescence dysregulates fibrogenesis in response to infection with SARS-CoV-2. There is a need to further investigate the mechanisms for these changes.
Reactivity of Unconventional Fly Ashes, SCMs, and Fillers: Effects of Sulfates, Carbonates, and Temperature
Authors: Wang Ying , Ramanathan Sivakumar , Burris Lisa , Hooton R. Douglas , Shearer Christopher R. , Suraneni Prannoy 
Published: August 2022

Abstract
Reactivity information for a range of unconventional fly ashes is unavailable in literature. The objective of this study is to quantify the reactivity of numerous unconventional fly ashes using the R3 test (ASTM C1897-20, Standard Test Methods for Measuring the Reactivity of Supplementary Cementitious Materials by Isothermal Calorimetry and Bound Water Measurements) and the modified R3 test and to determine how sulfates, carbonates, and temperature affect the measured reactivity. A small set of other supplementary cementitious materials and fillers was used to benchmark the fly ash results. Heat release, calcium hydroxide consumption, and bound water were measured for the different materials. For siliceous materials with relatively low calcium oxide (CaO) + aluminum oxide (Al2O3) contents, temperature had a dominant effect on the heat release. On the other hand, for materials with higher CaO + Al2O3 contents, the effects of sulfates and carbonates dominated the effect of temperature. The slow but sustained reactivity of Class F fly ashes highlighted the importance of kinetic corrections or extrapolations to the reactivity measured in the R3 test. However, when testing at 50°C, the heat release curves of all tested materials plateaued at the end of 10 days, indicating that kinetic corrections were not required. Correlations between reactivity and early- and later-age paste properties are discussed.
Biosynthesis of ZnO Nanoparticles from Aqueous Extract of Moringa Oleifera L.: Its Application as Antibacterial and Photocatalyst
Authors: Rhamdiyah Fastabiqul Khairati , Maharani Dina Kartika 
Published: August 2022

ZnO nanoparticles were successfully synthesized by the biosynthesis method using water extract of Moringa leaf (Moringa oleifera L.) as a reducing agent and stabilizer as well as a capping agent. This study aimed to characterize ZnO nanoparticles and their application as antibacterial and photocatalyst. Characterization was carried out using Fourier Transform Infrared (FT-IR) Spectroscopy and X-Ray Diffraction (XRD). The biosynthesis ZnO nanoparticles have a hexagonal wurtzite phase with an average crystal size of 16.97 nm and a crystallinity level of 78.49%. Antibacterial activity of ZnO nanoparticles with concentrations of 3%, 6%, 9% resulted in an average inhibition zone of bacterial growth in S. aureus was 19.6 0.16; 21.8 0.33; 24.3 0.14 and in E.coli it is 9.87 0.2; 11.3 0.04; 11.57 0.06. The greater the concentration of ZnO nanoparticles, the larger the diameter of the inhibition zone. The result of photodegradation of methylene blue is greatest with variations in the mass of ZnO nanoparticles and the concentration of methylene blue is 95% with a nanoparticle mass of 120 mg, methylene blue concentration of 10 ppm, and an irradiation time of 150 minutes.
OXIDATIVE STRESS AND REPRODUCTIVE FUNCTION: The impact of oxidative stress on reproduction: a focus on gametogenesis and fertilization
Authors: Aitken R John , Bromfield Elizabeth G , Gibb Zamira 
Published: August 2022

In briefMany aspects of the reproductive process are impacted by oxidative stress. This article summarizes the chemical nature of reactive oxygen species and their role in both the physiological regulation of reproductive processes and the pathophysiology of infertility.AbstractThis article lays out the fundamental principles of oxidative stress. It describes the nature of reactive oxygen species (ROS), the way in which these potentially toxic metabolites interact with cells and how they impact both cellular function and genetic integrity. The mechanisms by which ROS generation is enhanced to the point that the cells’ antioxidant defence mechanisms are overwhelmed are also reviewed taking examples from both the male and female reproductive system, with a focus on gametogenesis and fertilization. The important role of external factors in exacerbating oxidative stress and impairing reproductive competence is also examined in terms of their ability to disrupt the physiological redox regulation of reproductive processes. Developing diagnostic and therapeutic strategies to cope with oxidative stress within the reproductive system will depend on the development of a deeper understanding of the nature, source, magnitude, and location of such stress in order to fashion personalized treatments that meet a given patient’s clinical needs.
Comparison studies on sucrose metabolism and phenolic content during fruit growth and maturation in pear cultivars
Authors: Kaur A. , Sharma S. , Navprem S. 
Published: August 2022

Abstract
‘Patharnakh’ (Pyrus pyrifolia Burm.) (PN), a hard pear and ‘Punjab Beauty’ (Pyrus communis L. × Pyrus pyrifolia Burm.) (PB), a soft pear are dominant low-chill pear cultivars of subtropics of India. Present investigation reports the changes in sugar metabolism and related enzymatic activities in fruits of ‘PN’ and ‘PB’ cultivars harvested at different developmental stages from 45 to 150 days after fruit set. Total soluble sugars, fructose, and sucrose contents were higher in ‘PB’ as compared to ‘PN’ during fruit growth and maturation stages. Total phenols and flavanols increased initially and then showed a decreasing trend towards maturity. Sucrose synthase (SS) and sucrose phosphate synthase (SPS) activities strongly correlated to sucrose content in ‘PN’ but SPS was weakly related in ‘PB’ fruits. Acid and neutral invertases showed a negative correlation with sucrose content in ‘PN’, and a reverse trend in ‘PB’ cultivar was observed. It is concluded that SS and SPS are crucial for sucrose accumulation in ‘PN’, but invertase enzymes are also important for sucrose accumulation in ‘PB’ fruits.
Sistematización acerca de la extensión universitaria como un proceso formativo
Authors: Alvarez Yudit Rovira , Valdés Aylén Rojas , Ruizcalderón Manuel Vento , Bencomo Osmani Alvarez 
Published: August 2022

El artículo aborda la extensión universitaria como un proceso formativo en el contexto de la Universidad de Pinar del Río, Cuba. El objetivo estuvo dirigido a su socializar un enfoque reflexivo – crítico acerca del carácter formativo de la extensión universitaria fundamentado en cuatro concepciones pedagógicas, de las que se presentan sus ejes fundamentales. El estudio se realizó desde el enfoque cualitativo y como métodos fundamentales estuvieron el dialéctico- materialista como soporte teórico, práctico y metodológico de la investigación, así como teóricos como el histórico–lógico en correspondencia con cada una de las concepciones dirigidas a la formación para la promoción de lectura, la formación de promotores de estilos de vida saludables, la formación para la labor extensionista del estudiante y la gestión de la extensión en el Departamento Docente. Las conclusiones que se presentan, son de tipo teórico y resultan generalizables a contextos universitarios y territoriales de manera general, permitieron corroborar el carácter formativo del proceso, dado en la transversalidad, la profesionalización, la formación integral, el Departamento docente, como célula de trabajo extensionista y las relaciones de jerarquización, coordinación, subordinación entre los diferentes actores universitarios.
Entrevista: A didática na formação inicial de professores para a atuação na educação básica, com Ilma Passos Alencastro Veiga
Authors: Silva Edileuza Fernandes , Moulin Maria Alessandra Lima 
Published: August 2022

Esta entrevista discute a didática na formação inicial de professores para a atuação na educação básica a partir do diálogo com Ilma Passos Alencastro Veiga, Professora Emérita da Faculdade de Educação da Universidade da Brasília. São abordadas questões teórico-práticas que retomam experiências, estudos, pesquisas e produções da entrevistada acerca da disciplina Campo da Pedagogia, a qual cumpre papel central na formação didático-pedagógica nas licenciaturas. A Didática é disciplina do currículo de cursos de licenciatura que tem como objeto o ensino com vistas às aprendizagens dos estudantes. Fundamentada na relação teoria-prática, concretiza-se no ato educativo para o alcance das finalidades da educação básica. As reflexões possibilitadas pelas questões indicam que o confronto entre teoria e prática foi uma constante na formação da autora, bem como em sua atuação profissional, levando-a a questionamentos acerca da Didática na formação docente. Suas reflexões reafirmam a complexidade da formação de professores e a relevância dessa disciplina nesse processo, portanto, é necessário repensar a Didática para os cursos de licenciatura de forma democrática, com discussões abertas e críticas. Seu desafio atual é a convergência para uma proposta de Didática inovadora, fundamentada na Pedagogia Histórico-Crítica.
MICROWAVE ASSISTED-EXTRACTION OF ESSENTIAL OIL FROM FRESH BASIL (OCIMUM BASILICUM L.) LEAVES
Authors: Ditta Kharisma Yolanda Putri  , Atiqa Rahmawati  
Published: August 2022

In this research, the extraction of essential oil from fresh basil leaves using solvent-free microwave extraction (SFME)and microwave hydrodistillation (MHD) method. Several parameters influence the extraction of basil oil using SFME method: microwave power, the ratio between the mass of raw material with a volume of distiller (F/D), material size, and length of extraction time. Besides, the components contained in basil oil and changes in oil gland conditions in basil leaves before and after being extracted were also evaluated. The optimum condition was obtained as follows: microwave power of 380 W, the ratio between the mass of raw material with a volume of distiller (F/D) of 0.1 g/mL, raw material size of intact (± 3 cm), with an extraction time of 60 min. Moreover, SFME has a shorter extraction time to produce yields than MHD methods. GC-MS analyzed the composition of basil oil, and there were 49 identified components. This study shows that SFME method more effective than the MHD method for extraction basil oil from fresh leaves based on time extraction and yield.
QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDY OF ESTER-BASED FERULIC ACID DERIVATIVES AGAINST CERVICAL CANCER CELL (HELA)
Authors: Helda Wika Amini  , Istiqomah Rahmawati  , Rizki Fitria Darmayanti  , Boy Arief Fachri  
Published: August 2022

Quantitative structure-activity relationship (QSAR) has been studied for ferulic acid derivatives to determine the QSAR model able to predict anticancer. As the subject of this research was a set of experimentally calculated IC50 value data of 6 ferulic acid derivatives against cervical cancer cells (HELA).
QSAR analysis was based on multilinear regression calculation on fitting subset using log (1/IC50) as the dependent variable, and dipole moment, partition coefficient in the n-octanol/water, and atomic net charges of the aromatic carbons as independent variables. The values of the descriptors were
obtained from semiempirical PM3 quantum mechanic calculation. The relationship between log (1/IC50) and the descriptors was described by the result in the QSAR model. The QSAR model for ferulic acid derivatives against HELA cell lineswas developed with the statistical parameters of R=0.998; R2=0.999; SE=0.00857; and F=394. The calculated log (1/IC50) using QSAR Hansch Model for ferulic acid derivatives have excellent agreement with experimental data of Log (1/IC50).
Hubungan Ketakutan akan Hipoglikemia dengan Manajemen Diri Pasien Diabetes Melitus Tipe 2 di RSD dr. Soebandi Jember
Authors: Roessanti Novian Dwi , Sutawardana Jon Hafan , Kushariyadi Kushariyadi 
Published: August 2022

Hypoglycemia is a complication of diabetes that causes unpleasant symptoms and fear for recurrence. This fear can influence diabetes management and patient metabolic control. The study aimed to analyze the relationship between fear of hypoglycemia and self-management of type 2 DM patients at dr. Soebandi Jember general hospital. The fear of hypoglycemia variable was measured using the Fear of Hypoglycemia Scale questionnaire (FH-15) and the variable of diabetes self-management was measured by the Diabetes Self-Management Questionnaire (DSMQ). The sample was 84 respondents that recruited using consecutive sampling method. Data was analyzed using the Spearman correlation test with α = 0.05. The results showed that patients did not experience fear of hypoglycemia (78.6%) and self-management of diabetic patients showed a good category (77.4%). There is a significant and positive correlation between the two variables (p-value = 0.012 and r = 0.272) which means that the more fearful the patient the more self-management gets worse, and conversely the less afraid of the patient the better self-management of diabetes. Family involvement is support for patients in controlling their fears, recognizing signs of hypoglycemia and as a reminder in managing proper diabetes. Diet control is an indicator of diabetes management that must be considered for patients to improve their health status by optimizing nutrition to prevent recurrent hypoglycemia.
En torno a la externalización de actividades empresariales y la posible cesión ilegal de trabajadores en el ámbito de las plataformas digitales
Authors: Jurado Segovia Angel 
Published: August 2022

En el ámbito de las denominadas plataformas digitales, un nuevo episodio susceptible de generar un cierto debate y conflictividad jurídico-laboral está ya en ciernes y trae causa en que la Inspección de Trabajo y Seguridad Social ha entendido que las prácticas de subcontratación de actividades de empresas como Amazon y Cabify conculcan la prohibición de cesión de trabajadores establecida por la normativa laboral. Tomando como ineludible punto de referencia la jurisprudencia en torno a la distinción entre contratas lícitas y cesiones ilegales, el presente trabajo analiza críticamente los principales criterios y razonamientos que habría manejado la Inspección de Trabajo para llegar a tal conclusión. El estudio contiene, asimismo, algunas consideraciones que encuadran el tema analizado en un marco más amplio de reflexión relativo a la regulación jurídico-laboral de los fenómenos de externalización de actividades empresariales.
Digitalización y sucesión de empresa
Authors: Martínez Saldaña David 
Published: August 2022

La sucesión de empresa de la Directiva 2001/23 CE, traspuesta en España en el artículo 44 del Estatuto de los Trabajadores, es una institución que, en esencia, tiene por objeto proteger los derechos de los trabajadores, asegurando que, cuando se transmite una empresa, centro de trabajo o unidad productiva autónoma, los trabajadores sean subrogados y exista una responsabilidad solidaria, laboral y de seguridad social por las obligaciones devengadas antes de la transmisión. Los imparables cambios e irrupciones que se están produciendo en el concepto de empresa, que está basculando de un concepto tradicionalmente basado en los bienes materiales y la maquinaria a un concepto intensivo en componentes inmateriales y digitales (clientela, algoritmos, aplicaciones informáticas, software, inteligencia artificial, etc.), están provocando una profunda transformación en lo que debe entenderse por una empresa. En la medida en que el concepto de empresa está cambiando, se modifica, igualmente, el concepto de sucesión. Este trabajo tiene por objeto analizar el criterio jurisprudencial sobre el “valor de los medios inmateriales antes de la transmisión”.
Konstelasi kekuatan partai politik dalam pemilu serentak tahun 2019 di Kabupaten Pemalang
Authors: Harto Unggul Sugi 
Published: August 2022

The general election is a contestation involving political parties and individuals in a democracy, where various processes and details follow. The result of the election is a number of vote which are then converted into seats in the legislature or the electability of the elite. These two results the become materials that are constantly being studied and analyzed, of course with various basid research objectives. The number of good votes obtained by political parties, legislative candidates, regional elite candidates to the president is rich in meaning and shows a variety of studies. Figures obtained by political parties both of the national level, especially at the regional level, have variouse aspect, such as strength of the party the power of the political machine or the level of competition in the region. These meanings are quite reasonable because the number of party votes, especially in the regoins, shows the dynamics closest to the vasiouse phenomena of the competition between political parties themselves. The study of the vote acquisition of political parties in regions, especially the districts, is a micro study developed by the electoral district (Daerah Pemilihan/Dapil). This constituency is the main point for cq’s vote. Seats in the regional legislature as well as evidence of the strength of political parties in the electoral district. Many variations appear when reading the vote count, of course, because each electoral district has has certain characteristics that tend to be relatively different. This study focuse on the vote acquisition of political parties in the electoral district in Pemalang Regency, Central Java. Pemalang Regency is located in the North West part of Central Java, and is crossed by national arterial road known as The Pantura (Pantai Utara Jawa). The large base political parties is PDI P, PKB, Gerindra, P Golkar, PPP and PKS, a political party strength which is also manifesd in the national political map. The vote gain of political parties are the looked at per eletoral district and then compared between parties, and the result is a vairety of variations as a result of the local poltical prosesses of each different electoral district.
Stress Reduction Training Based on Mindfulness Method to Enhance Self-control Among Rehabilitation Patient in Orbit Hospital, Surabaya
Authors: Maya Vratasti I Gusti Ayu , Alrbertina Christina 
Published: August 2022

ABSTRAK
Anggota Rehabilitasi Rumah Sehat Orbit Surabaya (RSOS) mengalami permasalahan dalam kontrol diri berdasarkan penggalian data awal melalui proses wawancara. Permasalahan tersebut menghambat proses pemulihan anggota rehabilitasi dari penggunaan NAPZA. Anggota rehabilitasi perlu untuk meningkatkan kontrol diri untuk dapat memaksimalkan proses pemulihan selama proses rehabilitasi dan mampu mempertahankan perilaku untuk tidak kembali menggunakan NAPZA pasca rehabilitasi. Berdasarkan beberapa penelitian menunjukan bahwa mindfulness base stress rduction (MBSR) efektif untuk menimgkatkan kontrol diri pada individu. Penelitian ini bertujuan untuk menguji pengaruh pelatihan mindfulness base stress rduction (MBSR) untuk meningkatkan kontrol diri pada anggota rehabilitasi Rumah Sehat Orbit Surabaya (RSOS). Metode penelitian yang digunakan adalah eksperimen. Partisipan dalam penelitian ini sebanyak 11 orang. Partisipan akan dilihat perbedaan skor sebelum dan sesudah intervensi diberikan. Berdasarkan hasil uji beda yang telah dilakukan diperoleh hasil signifikansi sebesar 0,004 (<0,05) pada kontrol diri dan 0,011 (<0,05) pada mindfulness. Hal ini mennjukan bahwa terdapat perbedaan yang signifikan sebelum dan sesudah diberikan pelatihan mindfulness base stress rduction (MBSR). Melatih mindfulness secara rutin membantu individu lebih mampu untuk melihat ke dalam diri serta mengenali kemampuan diri sehingga individu merasa memiliki kontrol akan dirinya.
The Impact of loneliness and romantic relationship status towards quality of life among adult single women in Indonesia
Authors: Gazadinda Rahmadianty , Pasaribu Maria Mutiara Christina 
Published: August 2022

Perempuan yang masih melajang di usia yang umumnya sudah menikah seringkali mendapatkan stigma bahwa dirinya mengalami kesepian. Ketidakhadiran pasangan dalam hubungan institusi berbentuk pernikahan pada perempuan dewasa dianggap memberikan dampak terhadap kondisi psikologisnya, salah satunya adalah kualitas hidup. Padahal, perempuan lajang memiliki kondisi spesifik yang juga dapat memberikan fungsi protektif pada kualitas hidupnya. Penelitian ini dilakukan untuk mengidentifikasi adanya pengaruh kesepian dan status hubungan romantis terhadap kualitas hidup pada perempuan lajang dewasa di Indonesia. 200 perempuan lajang berusia 28-40 tahun dilibatkan sebagai partisipan dalam penelitian ini. Hasil penelitian menemukan bahwa terdapat pengaruh yang signifikan antara kesepian dan status hubungan romantis terhadap kualitas hidup ditinjau dari perspektif subjektif F(3, 196) = 16.053; sig. 0.000; R Square=0.197). Namun begitu, tidak ditemukan adanya efek interaksi antara tingkat kesepian dan status hubungan romantis terhadap seluruh dimensi kualitas hidup F(3, 197) = 2.267, p = 0.063; Wilks’Lambda=0.96; Partial eta squared = 0.05). Hanya tingkat kesepian yang ditemukan berkontribusi signifikan terhadap keempat dimensi kualitas hidup.

Kata kunci: Kesepian, kualitas hidup, lajang, perempuan, status hubungan romantis
Validitas Konstruk Porter Parental Acceptance Scale (PPAS) Pada Orang Tua Anak Dengan Autis
Authors: Tati Sumiati Neneng , Tresniasari Nia , Syanindia Annisa Dewi  
Published: August 2022

Parental acceptance has an important role in determining successful parenting. Parents who can accept are positively sensitive to their children’s needs and children’s development. In this case, Porter Parental Acceptance Scale (PPAS) was used to measure the degree to which parents may be said to accept their children. This study aims to examine the construct validity of PPAS on 200 parents of autistic children in Indonesia. Data were collected using non-probability sampling techniques and administered through online questionnaires. Data were analyzed using confirmatory factor analysis (CFA). The result show that the model was classified as fit with Chi-Square = 611.33, df = 579, P-Value = 0.17045, RMSEA = 0.017. All items are valid, except item numbers 3, 5, 6, 8, 9, 34, 38. The implication is PPAS can be used to measures parental acceptance levels as indicated by the feelings and behaviors expressed toward their child.