bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pembrolizumab combined with Axitinib in ASPSCR1-TFE3 gene fusion translocation renal cell carcinoma: a case report and literature review
Authors: Bai Yinmiao , Wang Xiaowen , Liu Yang , Ji Hongchen , Liu Zhihui , Sun Juanhua , Zhang Hong-Mei 
Published: October 2022

Abstract
Background: Translocation renal cell carcinoma (tRCC) is a subtype of nccRCC driven by MiT/TFE gene fusion. The demographic characteristics of tRCC include younger age at diagnosis, later staging at diagnosis, high degree of malignancy, poor prognosis, and female majority. There are currently no standard guidelines for the diagnosis and treatment of this type of kidney cancer. Objective: To investigate the efficacy of immuncheckpoint blockadeinhibitor combined with anti-VEGF receptor tyrosine-kinase inhibitors in ASPSCR1-TFE3 gene fusion translocation renal cell carcinoma(tRCC).
Case presentation: The paper describes a case of a 42-year-old Chinese female presented enlargement of multiple lymph nodes. Percutaneous aspiration cytology of the tumor on the left side of neck lymph node was confirmed to be malignant. Combined with pathology, PET-CT and genetic testing, the patient was diagnosed with ASPSCR1-TFE3 gene fusion tRCC with multiple metastases (left kidney, cT1aN1M1, stage IV), involving lymph nodes,liver, and bone. The patient was treated with Pembrolizumab combined with Axitinib. Up to June 2022, the patient's progression-free survival time was was more than 2 years, lesions in left kidney, lymph nodes, liver and bone reached stable status, partial response, complete response and stable status, respectively. The patient can receive treatment for side effects.
Conclusions: The report of this case could provide a helpful strategy for combination therapy of PD-1 antibody and VEGFRs inhibitor in rare ASPSCR1-TFE3 gene fusion tRCC.
Genomic Evolution of Sars-Cov-2 in Molnupiravir-Treated Patients Compared to Paxlovid-Treated and Drug-Naïve Patients: A Proof-of-Concept Study
Authors: Alteri Claudia , Fox Valeria , Scutari Rossana , Burastero Giulia Jole , Volpi Sara , Faltoni Matteo , Fini Vanessa , Granaglia Annarita , Esperti Sara , Gallerani Altea , Costabile Valentino , Fontana Beatrice , Franceschini Erica , Meschiari Marianna , Campana Andrea , Bernardi Stefania , Villani Alberto , Bernaschi Paola , Russo Cristina , Guaraldi Giovanni , Mussini Cristina , Perno Carlo 
Published: October 2022

Abstract
Molnupiravir and Paxlovid are the only antivirals approved for COVID-19 treatment. Previous studies have evaluated their efficacy, tolerability, and viral clearance, but little is known about SARS-CoV-2 evolution under their pressure. Here the dynamics of genomic evolution of SARS-CoV-2 in 8 Molnupiravir-treated, 7 Paxlovid-treated and 5 drug-naïve individuals at 4 time-points (Day 0, Day 2, Day 5 of treatment and Day 7) were in-depth investigated. SARS-CoV-2 strains under Molnupiravir pressure were characterized by a higher genetic diversity compared to Paxlovid and no-drug pressure (mean ± SE: 18.66x10− 4±2.06x10− 4 vs. 3.34x10− 4±0.84x10− 4 vs. 3.10x10− 4±0.84x10− 4, P = 0.0003), with a peak between Day 2 and Day 5. Molnupiravir drove the emergence of more G-A and C-T transitions than other mutations (P = 0.031), regardless of SARS-CoV-2 genes. SARS-CoV-2 under Molnupiravir pressure did not show selective evolution different than that under Paxlovid or no-drug pressure, with the only exception of orf8 (dN > dS, P = 0.001); few amino acid mutations were enriched consistently at specific sites. No evidence of RdRp or Mpro mutations conferring resistance to Molnupiravir or Paxlovid was found. This proof-of-concept study defines the SARS-CoV-2 within-host evolution during antiviral treatment, confirming the higher in vivo variability induced by Molnupiravir respect to Paxlovid and controls, albeit not resulting in selection of resistance mutations.
Synthesis and cytotoxic/antimicrobial screening of 3-alkenylimidazo[1,2-a]pyrimidines
Authors: Ramírez-Trinidad Angel , Carrillo-Jaimes Karol , Rivera-Chávez José A. , Hernandez-Vazquez Eduardo 
Published: October 2022

Abstract
Polyaza-heterocycles show a plethora of biological properties and represent a significant percentage of clinically used drugs. However, the imizado[1,2-a]pyrimidine ring system needs more attention in terms of pharmaceutical applications. Herein, we report a sequence involving an aldolic condensation/bromination/Hantzsch reaction to construct a series of 3-alkenylimidazo[1,2-a]pyrimidines for exploring their cytotoxic and antimicrobial properties. After performing a preliminary screening, two compounds displayed good cytotoxicity against prostate, breast, and colon cancer types; bulky and an extra phenyl attached at the styryl moiety seem to be a requirement for good activity. With respect to the antimicrobial effect, some compounds showed considerable inhibition against multi-drug resistant K. pneumoniae, one of the most threating bacteria nowadays. Thus, the series may become the basis for the design of more active compounds.
A Distributed Static Time-varying Feedback for Formation Tracking Control of 2nd-order Nonholonomic Systems with Cooperative-Competitive Interactions
Authors: Xie Wenjing 
Published: October 2022

Abstract
Formation tracking task is generally achieved by designing dynamic controllers, which yield additional inertial effects and may increase the difficulty of algorithm implementation. This paper presents a new static feedback to solve the formation tracking control problem of 2nd-order nonholonomic systems with cooperative-competitive interactions. Firstly, a time-varying position output is constructed to obtain double-integrator dynamics. Compared with the traditional hand position output, the constructed output makes it possible to achieve both small control inputs and small ultimate bound, and hence renders the resulting feedback more beneficial to practical applications. Then, the feedback is designed as the proportional derivative type with a correcting term, which overcomes the difficulty of controlling higher relative-degree system, and removes the dependence of control coefficients on spectral feature of interaction network. Rather than using external variables, the static feedback involves the special correcting term to eliminate the residual error caused by dynamic leader who is unavailable to some systems. Global uniform ultimate boundedness of the closed-loop double-integrators is strictly proved by applying Lyapunov method, graph theory and cascaded system theory. After this, a technical lemma about nonlinear system is developed to clarify the convergence of orientation and angular velocity under some persistently exciting condition on leader. Finally, simulations for six 2nd-order nonholonomic systems are carried out to demonstrate the formation tracking performance of the proposed static feedback controller.
A direct nonlinear humidity and temperature tracking controller for an air-handling unit based on backstepping scheme
Authors: Sun Yulong , Liu Cungen , Li Xiangbao , Peng Wei , Liu Xiaotong 
Published: October 2022

Abstract
Aim at an air-handling unit (AHU), this article describes a direct design scheme for humidity and temperature tracking control. The nonlinear dynamic model of the AHU is treated directly by backstepping strategy, which can reserve the modeling qualifications and make better use of known information than proportion integration differentiation (PID) and other non-model-based schemes. Simultaneously, the linearization technique is not adopted, so that the model structure is not changed, which can retain the original system model restrictions to variables and does not lose useful conditions about the system model. These two points ensure the developed controller to achieve higher accuracy and better tracking performance, which is verified by stability analysis and comparisons of simulation results.
Number of psychotropic medications on admission and fall or injury diagnoses in older adults admitted to a large urban hospital from 2016-2021: opportunities for deprescribing
Authors: Keller Michelle Sophie 
Published: October 2022

Abstract
To prepare for an intervention aimed at increasing inpatient/post-discharge counseling about the risks of and deprescribing potentially inappropriate psychotropic medications, we examined sedative use on admission in a large urban hospital over a 5-year period and focused on older adults admitted for a fall or injury diagnosis.
Clinical Manifestations and Progression of Varicella among Adults at Siriraj Hospital, Thailand: A Prospective Cohort Study
Authors: Jiamton Sukhum , Chanyachailert Pattriya , Phumariyapong Phumithep , Nanchaipruek Yanisorn 
Published: October 2022

Abstract
Varicella is a highly contagious viral disease that is very common in children. Adults are less likely to acquire varicella; however, therate of its complication is higher. There are few published data on varicella among adults in Thailand. This study aimed to demonstrate the clinical manifestations, progression and environmental factors of varicella in adults.
From January 2018 to June 2022, a prospective cohort study was conducted among adult patients diagnosed with varicella visiting Siriraj Hospital. Demographic data, history of varicella and varicella vaccination, onset, types of lesions, and distribution were recorded. Participants were followed until the varicella was completely cured. During the study, the average temperature of each month was recorded.
Fifty patients were included inthe study. Interestingly, varicella was diagnosedin patients with a history of varicella infection (18%) or varicella vaccination (14%), especially in healthcare providers. Generalized vesicles were the most common manifestation. From the univariate or multivariate analysis, the duration of the curewas shown to be significantly shorter among those who had a history of vaccination by approximately 3 days (p=0.007). The duration of cure was not significantly associated with age, sex, receiving treatment within 48 hours after the initial lesions, or having a history of previousvaricella. Interestingly, the number of varicella patients per month was found to be significantly lower in months with an average temperature greaterthan 30 degrees Celsius (p<0.0001).
Our findings demonstrated that varicella reinfection occurs in Thai adults and in those with a history of vaccination. Adults who had been vaccinated had a significantly shorter duration of the disease. Therefore, varicella vaccination is recommended, particularly among healthcare professionals who may have contact with varicella patients.
Effect of irrigation scheduling and residue management tillage on soil water balance and growth of wheat
Authors: Singh Malkit , Singh Kanwar Barjinder , Brar Satinder Singh , Singh Baljit 
Published: October 2022

Abstract
The present study was conducted in wheat at the Punjab Agricultural University Seed Farm, Ladhowal, Ludhiana, to study effect of three irrigation regimes ( based on IW/PAN-E ratio of 0.6 (I1), 0.8 (I2) and 1.0 (I3) in main plots and four tillage practices (mould board ploughing to a depth of 25 cm followed by rotavator (PT25 + R), mould board ploughing to a depth of 14 cm followed by rotavator (PT14 + R), zero tillage with happy seeder (ZT) and conventional tillage with 2 discing + 2 cultivator followed by planking (CT) in sub plots) on soil water balance and crop growth for two consecutive years (2016-17 and 2017-18). Irrigation scheduling and tillage practices has no significant effect on plant germination and thousand grain weight. However overall mean plant height, leaf area index, root length density and root mass density were significantly higher in I3 over I1 and I2 by 2.1 & 2.8%, 16.82 & 7.75%, 2.04 & 5.22% and 5.82 & 8.73% respectively. During both the years straw and grain yield were significantly higher in I3 over I1 and I2. Significantly higher water productivity was observed in I2 over I1 and I3 by 27.38 & 2.26% in 2016-17 and 27.70 & 1.91% in 2017-18. During 2016-17 maximum water depletion was in I1 over I2 and I3 by 2.15 &4.86% and 4.5 & 7.52 in 2017-18. Over PT14 + R, ZT and CT, the tillage practice of PT25 + R significantly increased number of tillers by 5.13,19.42 & 11.82%, plant height by 3.44, 8.38 & 10.37%, leaf area index by 13.45, 26.17 & 27.36%, root length density by 19.30, 61.81 & 46.17% and root mass density by 35.90, 317.67 & 48.16% respectively. During both years significantly higher straw and grain yield were observed in PT25 + R over PT14 + R, ZT and CT. During both years significantly higher soil moisture storage was observed in I3 and ZT compared to other irrigation and tillage practices. Water balance component E&T were higher in PT25 + R than ZT.
Plexiform schwannomas of the sciatic nerve: a case report and review of the literature
Authors: Yan Jiabao , Zhou Ruijun , Liu Bingxin , Cao Xuewei 
Published: October 2022

Abstract
Background: Plexiform sciatic schwannoma is a rare tumor.Schwannoma is deceptive when it appears on the sciatic nerve. We report a rare case of plexiform sciatic schwannoma that was initially diagnosed as a lumbar disease.
Case Presentation: A 43-year-old female complained of pain in her low back and left thigh for 10 years.Physical examination and MRI confirmed that she had a rare plexiform sciatic schwannoma.After obtaining the patient's consent, we performed intracapsular excision of her tumor.The patient recovered well after operation and there was no sign of nerve injury.
Conclusions: Schwannomas in the sciatic nerve are misleading and doctors should pay attention to physical examination and MRI.Intracapsular excision is the best treatment for schwannomas.
Machine Learning Approach for Detecting and Combating Bring Your Own Device (BYOD) Security Threats and Attacks: A systematic Mapping Review
Authors: Eke Christopher Ifeanyi , Norman Azah Anir , Mulenga Mwenge 
Published: October 2022

Abstract
Bring your own device (BYOD) paradigm that permits employees to come with their own mobile devices to join the organizational network is rapidly changing the organizational operation method by enhancing flexibility, productivity, and efficiency. Despite these benefits, security issues remain a concern in organizational settings. A considerable number of studies have been conducted and published in this domain without a detailed review of the security solution mechanisms. Moreover, some reviews conducted focused more on the conventional approaches such as mobile content management, and application content management. Hence, the implementation of security in BYOD using the conventional method is ineffective. Thus, machine learning approaches seem to be the promising approach, which provides a solution to the security problem in the BYOD environment. This study presents a comprehensive systematic mapping review that focused on the application of the machine learning approach for the mitigation of security threats and attacks in the BYOD environment by highlighting the current trends in the existing studies. Five academic databases were searched and a total of 753 of the primary studies published between 2012 and 2021 were initially retrieved. These studies were screened based on their title, abstract and full text to check their eligibility and relevance for the study. However, forty primary studies were included and analyzed in the systematic mapping review (SMR). Based on the analysis and bubble plot mapping, significant research trends were identified on security threats and attacks, machine learning approaches, datasets usage, and evaluation metrics. The SMR result demonstrates the rise in the number of investigations regarding malware and unauthorized access to existing security threats and attacks. The SMR study indicates that supervised learning approaches such as SVM, DT, and RF are the most employed learning model by the previous research. Thus, there is an open research issue in the application of unsupervised learning approaches such as clustering and deep learning approaches. Therefore, the SMR has set the pace for creating new ground research in the machine learning implementation in the BYOD environment, which will offer invaluable insight into the study field, and researchers can employ it to find a research gap in the research domain.
Important factors to consider when choosing a sun protection product
Authors: Couteau Céline , Brenaut Emilie , Misery Laurent , Coiffard Laurence 
Published: October 2022

AbstractSun protection products serve as part of a strategy to prevent photoinduced skin cancers. The products currently on the market vary considerably, both in terms of their galenic formulation and their composition. Some are formulated using organic UV filters, some using mineral UV filters, and some using a mixture of both types. In this context, healthcare professionals, particularly dermatologists and pharmacists, are faced with selecting the product best suited to the patient/user, especially during summer. Our aim here is to establish a decision tree to enable an informed choice.
Diagnosis of autism spectrum disorder based on functional brain networks and machine learning
Authors: Alves Caroline , Toutain Thaise G. L. de O. , Aguiar Patricia de Carvalho , Pineda Aruane M. , Roster Kirstin , Thielemann Christiane , Porto  , Rodrigues Francisco A. 
Published: October 2022

Abstract
Autism spectrum disorder is a multifactorial neurodevelopmental disorder with high genetic heterogeneity. Studies of brain networks in autism can provide new insights into the dynamics of information processing in individuals who suffer from such a condition. This paper proposes a method for automatic diagnosis of autism based on fMRI time series and machine learning algorithms. We verify that the left ventral posterior cingulate cortex region reduces the functional connectivity of the brain area in patients with autism spectrum disorder. Also, the brain networks of patients with autism spectrum disorder show more segregation, lower distribution of information, and less connectivity. Our methodology accurately differentiates control and autistic subjects providing an area under the curve close to higher than 95%.
Seismic resurfacing of asteroid (433) Eros from cratering impact suggests presence of asteroid families in near-Earth space
Authors: Ballouz Ronald-Louis , Ernst Carolyn , Barnouin Olivier , Daly Ronald , DellaGiustina Daniella , Hyatt Benjamin , Martin Anna 
Published: October 2022

Abstract

An asteroid’s interior contributes to the response of its surface and shape to forces from space, including meteoroid impacts [e.g., Chapman 1996, Bottke et al. 2020], tidal effects [e.g., Hurford et al. 2016, Binzel et al. 2010], and solar radiation [Walsh et al. 2008]. Changes to asteroid surfaces from these external forces provide a record of the collisional and dynamical evolution of the inner Solar System [Bottke et al. 2020]. However, asteroid interiors remain poorly understood [Asphaug 2020].

(433) Eros is a 34 km x 11 km x 11 km diameter elongated near-Earth asteroid (NEA) with surface expressions that suggest a heavily fractured yet coherent interior, as evidenced by craters formed with structural control [Prockter et al. 2002] and by surface lineaments [Buczkowski et al. 2008], which are common features on 10-km-scale asteroids observed by spacecraft [Veverka et al. 1994, Barucci et al. 2015] that may be surface expressions of widespread interior fractures.

Here we report on measurements of the degradation of the D > 500 m crater population in the vicinity of the 7.5-km-diameter Shoemaker crater, indicating that seismic surface waves and crater ejecta, rather than seismic body waves [Richardson 2005, Thomas & Robinson 2005], erased craters with D < 500 m only up to 10 km away from the crater center. We use crater degradation measurements to estimate a surface wave seismic diffusivity of 0.02 km2/s for Eros regolith.

We determine from these observations that 10-100-km scale fractured asteroids strongly attenuate impact-induced seismic surface waves and seismic resurfacing is limited to local regions, less that 3 crater radii from the impact point.

Our results indicate that Shoemaker crater formed 6.5–31.8 Ma, while Eros was in a main-belt resonance zone. The age of Shoemaker crater coincides with the cosmic ray exposure age of some ordinary chondrites and the returned samples from the 0.3-km-diameter, S-type NEA Itokawa [Nagao et al. 2011]. The concurrence of ages suggests that large cratering impacts on to 10-km scale asteroids are an important source of NEAs and meteorites.
Strategies for Efficient Handling and Economic Circularity for Construction and Demolition Waste in India
Authors: Choudhary Sanjay , Kaur Harshita , Tripathi Bhavna , Chandra Tarush 
Published: October 2022

Abstract
The construction materials industry has been acclaimed as an enormous economy and is expected to continue to rise in future. Over the past few years, India's urban built environment has been expanding rapidly to accommodate the increasing urban population and to meet the rising aspirations of upscaling standards of living. In addition to new projects, redevelopment works are also prominent amongst the construction activities being undertaken all across our urban areas. The large-scale construction and demolition waste (C&D waste) is generated inadvertently from on-going construction activities with no major sustainable interventions or practices in place ever since. The state of art overview of C&D waste management practices and related legislation in India and select countries abroad provides sufficient opportunity for introducing and promoting circular economy (CE) in C&D waste management. This can be done through direct reuse or by recycling/ repair /refurbishment in different stages of construction projects. Reports on key infrastructure projects suggest project delays and cost over-run due to shortage of fresh stocks of primary construction materials. Promoting design of products or components remanufactured using dismantled or recycled C&D waste would no longer let the C&D waste remain as a threat to sustainable environment. Instead, the industry would get geared up to produce high-quality secondary raw materials that can be fed back into production processes. This will not just reduce the reliance on primary resources for construction materials like stone, sand, etc. but also promote the new business models which will focus on waste prevention and ‘turning waste into resources’ by effectively and efficiently utilizing C&D waste in a sustainable manner. This will embed circular economy in the system and also make the process more sustainable. Present models for sustainability assessment are primarily based on statistical records of C&D waste quantities and they rarely include all three aspects of sustainability (economic, environmental and social). This paper proposes a conceptual model of efficient C&D waste management strategies considering all the three aspects of sustainability. A conceptual model has been developed using the barriers and motivating factors obtained from literature review for implementation of effective C&D waste management for circular economy. Using existing knowledge of the components of C&D waste management system and the positive or negative relationships between them the proposed conceptual model focuses on strategies, institutional arrangement and economic circularity for managing the C&D waste. The paper highlights the need for an institutional framework and suitable strategies for efficient handling of C&D Waste. The paper concludes with possible future directions and potential policy recommendations for optimizing C&D waste management in India.