bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Levothyroxine on Oxidative stress and Lipid Profile in Hypothyroid Patients
Authors: Rahman Falguni Binte , Zubery Md Husnaion , Hossain Md Mosharruf , Ara Shahin , Alam Tarifat 
Published: March 2022

Background & Objective: Hypothyroidism is a common endocrine disorder and requires lifelong treatment. The present study was designed to evaluate the impact of levothyroxine (LT4) on the oxidative stress and metabolic state by assessment of malondialdehyde (MDA) level along with lipid profile in hypothyroid patients.
Methods: This cross-sectional analytical study was conducted in the Department of Pharmacology & Therapeutics, Rajshahi Medical College in collaboration with the Institute of Nuclear Medicine & Allied Sciences (INMAS), Rajshahi between July 2018 to June 2019 to compare malondialdehyde (MDA) level and lipid profile among hypothyroid patients, normal individuals and levothyroxine treated hypothyroid patients. The study included 20 newly-diagnosed hypothyroid patients, 20 Levo-treated hypothyroid patients and 20 healthy controls of both sexes.
Result: The MDA level was significantly highest in newly diagnosed hypothyroid patients among the three groups (p < 0.001). The mean of MDA level of hypothyroid patients, LT4-treated hypothyroid patients and normal healthy controls were 10.0 ± 2.13 μmol/l, 5.88 ± 1.90 μmol/l and 2.66 ± 0.61 μmol/l respectively. Significantly higher values of total cholesterol (TC) (198.5 ± 19.2 mg/dl), triglycerides (TG) (147.0 ± 14.5 mg/dl), low density lipoprotein-cholesterol (LDL-C) (133.9 ± 19.7 mg/dl), and a significantly decreased value of high density lipoprotein-cholesterol (HDL-C) levels (35.1 ± 3.67 mg/dl) were observed in newly-diagnosed hypothyroid patients as compared to those in Levo-treated hypothyroid patients and normal healthy individuals (p = 0.009).
Conclusion: The MDA level is significantly raised which suggests that people with hypothyroidism have high risk of free radical damage and risk of development of atherosclerosis, which may lead to coronary heart diseases (CHD). Treatment with LT4 significantly improves oxidative stress and corrects lipid profile but not up to the normal level. Addition of lipid lowering drugs and supplementation with antioxidants to traditional LT4 therapy can be tested to see further improvement in outcome parameters.
Ibrahim Card Med J 2021; 11 (1): 48-53
Outcome of Planned Vaginal Birth at Term after One Previous Caesarean Section
Authors: Hoque Humaira , Sultana Chowdhury Shamima , Laizu Hoshneara , Wareshuzzaman Md , Hossain Farhat 
Published: March 2022

Background & objective: Pregnant women with a previous caesarian section may be offered either vaginal birth or elective repeat caesarian section (ERCS). Detailed antenatal counseling and methodical intrapartum management of women are the key factors for success of planned vaginal birth after caesarean (VBAC). The present study was undertaken to determine the incidence of successful vaginal birth and the maternal and perinatal complications in patients undergoing planned vaginal birth after one previous caesarean section.
Methods: This prospective observational study was carried out in the Department of Obstetrics and Gynaecology, Sir Salimullah Medical College & Mitford Hospital (SSMC & MH), Dhaka over a period of one year between January to December 2016. A total of 96 term pregnant women, aged 20 – 35 years, having previous experience of one lower uterine caesarean section with spontaneous onset of labour, vertex presentation of the fetus and adequate pelvis were consecutively included in the study. The main primary outcome variable was fate of trial VBAC (successful vaginal delivery either spontaneous or assisted or ERCS). The secondary outcome variables were maternal and perinatal complications (morbidity and mortality).
Result: Over 55% of the women under trial VBAC were 25 – 30 years old with mean age of the women being 26.8 ± 3.7 years. Nearly three-fifths (58.3%) of the women were of normal BMI, 40.6% were overweight. None of the women was obese. Only 15% women had gestational age 40 weeks. The mean interval between the current and the previous births was almost 3 years. In terms of primary outcome, over 60% of the planed VBAC were successfully delivered (52.2% spontaneously and 9.3% with the aid of forceps and vacuum extraction). While maternal complications were uterine rupture (6.2%), hysterectomy (6.2%) and haemorrhage needing transfusion (14.6%), neonatal complications were respiratory distress syndrome (17.7%), perinatal death (10.4%), hypoxic ischemic encephalopathy (4.2%) and sepsis (8.3%).
Conclusion: The study concluded that planned VBAC is appropriate for majority of women with a singleton pregnancy of cephalic presentation who have had a single previous lower segment caesarean section (LSCS). However, as the maternal complications (like hysterectomy, haemorrhage etc.) and the perinatal complications including death were much high, utmost caution is advised in selecting the right candidate for VBAC so that the incidence of successful VB could be maximized and complications minimized.
Ibrahim Card Med J 2021; 11 (1): 54-61
Ultrasound Irradiation Assisted Synthesis of Luminescent Nano Amide-Functionalized Metal-Organic Frameworks; Application Toward Phenol Derivatives Sensing
Authors: Yan Xiao-Wei , Gharib Maniya , Esrafili Leili , Wang Su-Juan , Liu Kuan-Guan , Morsali Ali 
Published: March 2022

Two nano amide-functionalized metal-organic frameworks (MOFs) with molecular formula [Co(oba) (bpta)]·(DMF)2 TMU-50 and [Co2(oba)2 (bpfn)]·(DMF)2.5 TMU-51 obtained under ultrasonic method without any surfactants. The only difference between the two selected amide functionalized pillar ligands, N,N′-bis(4-pyridinyl)-terephthalamide (bpta), and N,N′-bis-(4-pyridylformamide)-1,5-naphthalenediamine (bpfn), is related to the naphthyl group, which led to the different luminescence properties of the nano frameworks. In this study, the special ability of the luminescent nano MOFs were investigated to sensitize nitroaromatic compounds. Due to its unique and porous framework, Nano TMU-50 shows a good sensitivity towards nitro phenol by strong fluorescence emission with a detection limit of 2 × 10–3 mM−1. Both nano MOF structures were characterized via many analyses such as powder X-ray diffraction, Field Emission Scanning Electron Microscopy (FE-SEM), elemental analysis, and FTIR spectroscopy. Moreover, the effect of a number of important parameters including initial reagent concentrations, power of ultrasound, time on morphology, and size of nano structures were examined. According to the fluorescence titration results, the activated nano-TMU-50 detected NP selectively with a quick response.
Salivary Microbiota and Host-Inflammatory Responses in Periodontitis Affected Individuals With and Without Rheumatoid Arthritis
Authors: Eriksson Kaja , Lundmark Anna , Delgado Luis F. , Hu Yue O. O. , Fei Guozhong , Lee Linkiat , Fei Carina , Catrina Anca I. , Jansson Leif , Andersson Anders F. , Yucel-Lindberg Tülay 
Published: March 2022

ObjectivesPeriodontitis and rheumatoid arthritis (RA) are two widespread chronic inflammatory diseases with a previously suggested association. The objective of the current study was to compare the oral microbial composition and host´s inflammatory mediator profile of saliva samples obtained from subjects with periodontitis, with and without RA, as well as to predict biomarkers, of bacterial pathogens and/or inflammatory mediators, for classification of samples associated with periodontitis and RA.MethodsSalivary samples were obtained from 53 patients with periodontitis and RA and 48 non-RA with chronic periodontitis. The microbial composition was identified using 16S rRNA gene sequencing and compared across periodontitis patients with and without RA. Levels of inflammatory mediators were determined using a multiplex bead assay, compared between the groups and correlated to the microbial profile. The achieved data was analysed using PCoA, DESeq2 and two machine learning algorithms, OPLS-DA and sPLS-DA.ResultsDifferential abundance DESeq2 analyses showed that the four most highly enriched (log2 FC &gt;20) amplicon sequence variants (ASVs) in the non-RA periodontitis group included Alloprevotella sp., Prevotella sp., Haemophilus sp., and Actinomyces sp. whereas Granulicatella sp., Veillonella sp., Megasphaera sp., and Fusobacterium nucleatum were the most highly enriched ASVs (log2 FC &gt;20) in the RA group. OPLS-DA with log2 FC analyses demonstrated that the top ASVs with the highest importance included Vampirovibrio sp. having a positive correlation with non-RA group, and seven ASVs belonging to Sphingomonas insulae, Sphingobium sp., Novosphingobium aromaticivorans, Delftia acidovorans, Aquabacterium spp. and Sphingomonas echinoides with a positive correlation with RA group. Among the detected inflammatory mediators in saliva samples, TWEAK/TNFSF12, IL-35, IFN-α2, pentraxin-3, gp130/sIL6Rb, sIL-6Ra, IL-19 and sTNF-R1 were found to be significantly increased in patients with periodontitis and RA compared to non-RA group with periodontitis. Moreover, correlations between ASVs and inflammatory mediators using sPLS-DA analysis revealed that TWEAK/TNFSF12, pentraxin-3 and IL-19 were positively correlated with the ASVs Sphingobium sp., Acidovorax delafieldii, Novosphingobium sp., and Aquabacterium sp.ConclusionOur results suggest that the combination of microbes and host inflammatory mediators could be more efficient to be used as a predictable biomarker associated with periodontitis and RA, as compared to microbes and inflammatory mediators alone.
Differences Between Takotsubo and the Working Diagnosis of Myocardial Infarction With Nonobstructive Coronary Arteries
Authors: Lopez-Pais Javier , Izquierdo Coronel Bárbara , Raposeiras-Roubín Sergio , Álvarez Rodriguez Leyre , Vedia Oscar , Almendro-Delia Manuel , Sionis Alessandro , Martin-Garcia Agustin C. , Uribarri Aitor , Blanco Emilia , Martín de Miguel Irene , Abu-Assi Emad , Galán Gil David , Sestayo Fernández Manuela , Espinosa Pascual Maria Jesús , Agra-Bermejo Rosa María , López Otero Diego , García Acuña Jose María , Alonso Martín Joaquín Jesús , Gonzalez-Juanatey Jose Ramón , Perez de Juan Romero Miguel Ángel , Núñez-Gil Iván J. 
Published: March 2022

AimWhether Takotsubo syndrome (TTS) should be classified within myocardial infarction with non-obstructive coronary arteries (MINOCAs) is still controversial. The aim of this work was to evaluate the main differences between TTS and non-TTS MINOCAs.Methods and ResultsA cohort study based on two prospective registries: TTS from the RETAKO registry (N:1,015) and patients with non-TTS MINOCAs from contemporary records of acute myocardial infarction from five 5 national centers (N:1,080). Definitions and management recommended by the ESC were used. Survival analysis was based on the Cox regression analysis; propensity score matching (PS) was created to adjust prognostic variables. Takotsubo syndrome were more often women (85.9 vs. 51.9%; p &lt; 0.001) and older (69.4 ± 12.5 vs. 64.5 ± 14.1 years; p &lt; 0.001). Atrial fibrillation (AF) was more frequent in non-TTS MINOCAs (10.4 vs. 14.4%; p = 0.007). Psychiatric disorders were more prevalent in TTS (15.5 vs. 10.2%, p &lt; 0.001). In-hospital mortality and complications were higher in TTS: 3.4 vs. 1.8%, (p = 0.015), and 25.8 vs. 11.5%, (p &lt; 0.001). Global mortality before PS matching was 16.1% in non-TTS MINOCAs and 8.1% in TTS. Median follow-up was 32.4 months; after PS matching, TTS had fewer major adverse cardiovascular events (MACEs): hazard ratio (HR) 0.59; 95% CI 0.42–0.83. There were no differences in global mortality (HR 0.87; CI: 0.64–1.19), but TTS had lower cardiovascular mortality (HR 0.58; CI: 0.35–0.98).ConclusionCompared to the rest of MINOCAs, TTS presents a different patient profile and a more aggressive acute phase. However, its long-term cardiovascular prognosis is better. These results support that TTS should be considered a separate entity with unique characteristics and prognosis.
Controls on Sediment Bed Erodibility in a Muddy, Partially-Mixed Tidal Estuary
Authors: Wright Cristin L. , Friedrichs Carl T. , Massey Grace M. 
Published: March 2022

The objectives of this study are to better understand controls on bed erodibility in muddy estuaries, including the roles of both sediment properties and recent hydrodynamic history. An extensive data set of erodibility measurements, sediment properties, and hydrodynamic information was utilized to create statistical models to predict the erodibility of the sediment bed. This data set includes &gt;160 eroded mass versus applied stress profiles collected over 15 years along the York River estuary, a system characterized by “depth-limited erosion,” such that the critical stress for erosion increases rapidly with depth into the bed. For this study, erodibility was quantified in two ways: the mass of sediment eroded at 0.2 Pa (a stress commonly produced by tides in the York), and the normalized shape of the eroded mass profile for stresses between 0 and 0.56 Pa. In models with eroded mass as the response variable, the explanatory variables with the strongest influence were (in descending order) tidal range squared averaged over the previous 8 days (a proxy for recent bottom stress), salinity or past river discharge, sediment organic content, recent water level anomalies, percent sand, percent clay, and bed layering. Results support the roles of 1) recent deposition and bed disturbance increasing erodibility and 2) cohesion/consolidation and erosion/winnowing of fines decreasing erodibility. The most important variable influencing the shape of the eroded mass profile was eroded mass at 0.2 Pa, such that more (vs. less) erodible cases exhibited straighter (vs. more strongly curved) profiles. Overall, hydrodynamic variables were the best predictors of eroded mass at 0.2 Pa, which, in turn, was the best predictor of profile shape. This suggests that calculations of past bed stress and the position of the salt intrusion can serve as useful empirical proxies for muddy bed consolidation state and resulting erodibility of the uppermost seabed in estuarine numerical models. Observed water content averaged over the top 1 cm was a poor predictor of erodibility, likely because typical tidal stresses suspend less than 1 mm of bed sediment. Future field sampling would benefit from higher resolution observations of water content within the bed’s top few millimeters.
Effects of Paternal Obesity on Fetal Development and Pregnancy Complications: A Prospective Clinical Cohort Study
Authors: Lin Jing , Gu Wei , Huang Hefeng 
Published: March 2022

ObjectivesTo evaluate the association between paternal obesity and fetal development and pregnancy complications.Study DesignThis prospective cohort clinical trial analyzed data from 7683 women with singleton pregnancies. All study subjects were sequentially divided into four groups based on paternal BMI. We compared the differences in fetal growth and pregnancy complications between different paternal BMI groups by univariate logistic regression and independent t-test. Finally, the independent predictors of SGA and macrosomia were determined.ResultsThe incidences of preeclampsia, cesarean section, SGA, macrosomia, and postpartum hemorrhage in the paternal obesity group were significantly higher than the normal BMI group. With the increase of paternal BMI, fetal ultrasound measurement parameter, neonatal and placental weight showed an increasing trend (trend P &lt; 0.05). However, these differences disappeared in the obese group. The test for interaction showed the effect of paternal obesity on SGA and macrosomia was significantly affected by maternal obesity. We also found paternal obesity was an independent predictor of both SGA and macrosomia. Based on the above results, we plotted the Nomograms for clinical prediction.ConclusionPaternal obesity can affect fetal growth parameters and placental development, which has an adverse impact on pregnancy outcomes. Optimizing the paternal BMI will help improve the health of the next generation.
Menopausal Impact on the Association Between Thyroid Dysfunction and Lipid Profiles: A Cross-Sectional Study
Authors: Han Yutong , Wang Chuyuan , Zhang Lihui , Zhu Jun , Zhu Mei , Li Yongze , Teng Di , Teng Weiping , Shan Zhongyan 
Published: March 2022

BackgroundBoth dyslipidemia and thyroid dysfunction have a high prevalence rate and are important risk factors for cardiovascular diseases. However, the relationship between blood lipids and thyroid dysfunction is still controversial. This study aims to analyze the blood lipids in people with different thyroid functions.MethodsA total of 80937 adults were included in this population-based cross-sectional TIDE survey, which collected demographic and clinical data on thyroid function, blood lipid levels and other metabolic indicators. After screening, the final analysis included 10,747 participants, who were divided into hypothyroidism (n=311), subclinical hypothyroidism (n=5015), hyperthyroidism (n=203), subclinical hyperthyroidism (n=118) and control (n=5100) groups. The risk of dyslipidemia was analyzed by a logistic regression model and divided into groups of female menopausal.ResultsAfter full adjustment, significant associations were found between hypothyroidism and hypertriglyceridemia. Subclinical hypothyroidism was associated with a significantly higher risk of hypertriglyceridemia and hyper-low density lipoprotein cholesterolemia. Hyperthyroidism was significantly correlated with a reduced risk of hypercholesterolemia and hyper-low density lipoprotein cholesterolemia but positively correlated with the risk of low-high density lipoprotein cholesterolemia. There was no significant association between subclinical hyperthyroidism and blood lipids. Hypothyroidism increased the risk of hypertriglyceridemia in both premenopausal and postmenopausal females. Subclinical hypothyroidism was significantly associated with increased hypertriglyceridemia and low-high density lipoprotein cholesterolemia in premenopausal females. Hyperthyroidism was significantly associated with a reduced risk of hypercholesterolemia and hyper-low density lipoprotein cholesterolemia in premenopausal females and an increased risk of low-high density lipoprotein cholesterolemia in postmenopausal female.ConclusionAbnormal thyroid function has an important effect on blood lipids and is closely related to female menopause.
Multi-Temporal SAR Interferometry for Vertical Displacement Monitoring from Space of Tengiz Oil Reservoir Using SENTINEL-1 and COSMO-SKYMED Satellite Missions
Authors: Bayramov Emil , Buchroithner Manfred , Kada Martin , Duisenbiyev Askar , Zhuniskenov Yermukhan 
Published: March 2022

This study focused on the quantitative assessment of the vertical displacement velocities retrieved using Sentinel-1 and Cosmo-SkyMed synthetic aperture radar images for the Tengiz oilfield. Tengiz oilfield was selected as a study area because of its historically reported continuous subsidence and limited up-to-date studies during recent years. The small baseline subset time-series technique was used for the interferometric processing of radar images acquired for the period of 2018–2020. The geospatial and statistical analyses allowed to determine the existing hotspots of the subsidence processes induced by oil extraction in the study area. Ground deformation measurements derived from the Sentinel-1 and COSMO-SkyMed satellite missions showed that the Tengiz oilfield continuously subsided during 2018–2020 with the maximum annual vertical displacement velocity around −77.4 mm/y and −71.5 mm/y, respectively. The vertical displacement velocities derived from the Sentinel-1 and the COSMO-SkyMed images showed a good statistical relationship with R2≥0.73 and RMSE ≤3.68 mm. The cumulative vertical displacement derived from both satellites for the most subsiding location also showed a good statistical relationship with R2 equal to 0.97 and RMSE = ± 4.69. The observed relative differences of measurements by both satellites were acceptable to determine the ongoing vertical surface displacement processes in the study area. These studies demonstrated a practical novelty for the petroleum industry in terms of the comparative assessment of surface displacement measurements using time-series of medium-resolution Sentinel-1 and high-resolution COSMO-SkyMed radar images.
Waste-to-Renewable Energy Transition: Biogas Generation for Sustainable Development
Authors: Atchike Desire Wade , Irfan Muhammad , Ahmad Munir , Rehman Mubeen Abdur 
Published: March 2022

To attain renewable energy goals, many developing countries, including Malaysia, acknowledge the adoption of waste-to-renewable energy (WTRE) technologies being the best means. The conversion of animal dung into biogas is one of the similar techniques. For a considerable amount of time, Malaysia has witnessed an increase in animal husbandry to generate massive feedstock, which can serve as the raw material for the generation of biogas. With the implementation of WTRE technologies, Malaysia is starting to use a suitable method of power generation from the conversion of animal dung to biogas. The application of an alternative method of power generation by Malaysia is converting animal dung to biogas. Use of animal dung conversion to biogas is considered as a suitable method for power generation. For the application of WTRE technologies, this phenomenon is examined by the current article. As a further step, a thorough analysis of Malaysia’s waste management issues and the energy mix has been done. The current issue at hand regarding the power generation in Malaysia is optimizing new and suitable energy sources. In this regard, WTRE transition has been identified as the primary and inevitable source of the energy transition. The article consists of an explanation of various technologies of power generation utilizing municipal waste. Malaysia’s massive potential capacity to produce biogas energy through waste has been analytically identified. Malaysian animal dung can yield biogas up to 1,317.20 mm3/annum, which can eventually result in power generation of 2.1 × 104 kWh/annum. Relevant policies are discussed for Malaysia to implement long-term biogas generation. This study did not include the obstacles to WTRE in Malaysia and other developing countries, providing an opportunity for future works to consider this research dimension.