bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bradley’s Relation Regress and the Inadequacy of the Relata-Specific Answer
Authors: Hakkarainen Jani , Keinänen Markku 
Published: April 2022

Abstract
F. H. Bradley’s relation regress poses a difficult problem for metaphysics of relations. In this paper, we reconstruct this regress argument systematically and make its presuppositions explicit in order to see where the possibility of its solution or resolution lies. We show that it cannot be answered by claiming that it is not vicious. Neither is one of the most promising resolutions, the relata-specific answer adequate in its present form. It attempts to explain adherence (relating), which is a crucial component of the explanandum of Bradley’s relation regress, in terms of specific adherence of a relational trope to its relata. Nevertheless, since we do not know the consequences and constituents of a trope adhering to its specific relata, it remains unclear what specific adherence is. It is left as a constitutively inexplicable primitive. The relata-specific answer only asserts against Bradley. This negative conclusion highlights the need for a metaphysical account of the constitution of the holding of adherence.
Impact of COVID-19 on Water Quality Index of river Yamuna in Himalayan and upper segment: analysis of monsoon and post-monsoon season
Authors: Sharma Shiwani , Gupta AnuShri 
Published: April 2022

AbstractRivers are the lifeline of every living being, be it humans or animals. Clean water is essential for everyone. However, increased urbanization and rapid industrialization have led to rising pollution level in rivers. COVID-19 on the contrary has changed the entire ecosystem. Limited industrial activities, reduced people movement during COVID times has led to improvement in environment, be it atmosphere or hydrosphere. Present work aims to study the impact of COVID-19 on water quality index of river Yamuna as it traverses from Himalayan segment to Upper segment. Five sites are chosen between a stretch of 60+ km, and samples are collected during monsoon and post-monsoon seasons. Physico-chemical parameters (pH, Turbidity, Sulphate, Phosphate, Fluoride, Chloride, Total Hardness, Calcium, Magnesium, Dissolved Oxygen, BOD, COD, Alkalinity), water quality index and Pearson correlation coefficient were calculated for all chosen sites. Since the study was initiated during COVID, initial results show the impact of reduced industrial and urban activities in improving the overall water quality.
What is the SKA-Low sensitivity for your favourite radio source?
Authors: Sokolowski M. , Tingay S. J. , Davidson D. B. , Wayth R. B. , Ung D. , Broderick J. , Juswardy B. , Kovaleva M. , Macario G. , Pupillo G. , Sutinjo A. 
Published: April 2022

AbstractThe Square Kilometre Array (SKA) will be the largest radio astronomy observatory ever built, providing unprecedented sensitivity over a very broad frequency band from 50 MHz to 15.3 GHz. The SKA’s low frequency component (SKA-Low), which will observe in the 50–350 MHz band, will be built at the Murchison Radio-astronomy Observatory (MRO) in Western Australia. It will consist of 512 stations each composed of 256 dual-polarised antennas, and the sensitivity of an individual station is pivotal to the performance of the entire SKA-Low telescope. The answer to the question in the title is, it depends. The sensitivity of a low frequency array, such as an SKA-Low station, depends strongly on the pointing direction of the digitally formed station beam and the local sidereal time (LST), and is different for the two orthogonal polarisations of the antennas. The accurate prediction of the SKA-Low sensitivity in an arbitrary direction in the sky is crucial for future observation planning. Here, we present a sensitivity calculator for the SKA-Low radio telescope, using a database of pre-computed sensitivity values for two realisations of an SKA-Low station architecture. One realisation uses the log-periodic antennas selected for SKA-Low. The second uses a known benchmark, in the form of the bowtie dipoles of the Murchison Widefield Array. Prototype stations of both types were deployed at the MRO in 2019, and since then have been collecting commissioning and verification data. These data were used to measure the sensitivity of the stations at several frequencies and over at least 24 h intervals, and were compared to the predictions described in this paper. The sensitivity values stored in theSQLitedatabase were pre-computed for the X, Y, and Stokes I polarisations in 10 MHz frequency steps,$\scriptsize{1/2}$hour LST intervals, and$5^\circ$resolution in pointing directions. The database allows users to quickly and easily estimate the sensitivity of SKA-Low for arbitrary observing parameters (your favourite object) using interactive web-based or command line interfaces. The sensitivity can be calculated using publicly available web interface (http://sensitivity.skalow.link) or a command linepythonpackage (https://github.com/marcinsokolowski/station_beam), which can also be used to calculate the sensitivity for arbitrary pointing directions, frequencies, and times without interpolations.
A Cross‐Cutting Approach for Relating Anthropocene, Environmental Injustice and Sacrifice Zones
Authors: Gayo Eugenia M. , Muñoz Ariel A. , Maldonado Antonio , Lavergne Céline , Francois Jean Pierre , Rodríguez Delia , Klock‐Barría Karin , Sheppard Paul R. , Aguilera‐Betti Isabella , Alonso‐Hernández Carlos , Mena‐Carrasco Marcelo , Urquiza Anahí , Gallardo Laura 
Published: April 2022

AbstractThe Anthropocene is an uneven phenomenon. Accelerated shifts in the functioning of the Earth System are mainly driven by the production and consumption of wealthy economies. Social, environmental and health costs of such industrialization, however, bear on low‐income communities inhabiting severely degraded territories by polluting activities (i.e., sacrifice zones). How global, national and local socio‐economic and governance processes have interacted in perpetuating socio‐environmental inequalities in these territories has been rarely explored. Here, we develop an historical quantitative approach integrating a novel chemostratigraphic record, data on policy making, and socio‐economic trends to evaluate the feedback relationship between environmental injustice and Anthropocene in sacrifice zones. We specifically outline a case study for the Puchuncaví valley ‐one of the most emblematic sacrifice zones from Chile‐. We verify an ever‐growing burden of heavy metals and metalloids over the past five decades paced by the staggering expansion of local industrial activities, which has ultimately been spurred by national and transnational market forces. Local poverty levels have declined concomitantly, but this path toward social equality is marginal as costs of pollution have grown through time. Indeed, national and international pollution control actions appear insufficient in mitigating the cumulative impact brought by highly toxic elements. Thus, our sub‐decadal reconstruction for pollution trends over the past 136 years from a sediment record, emerges as a science‐based tool for informing the discussion on Anthropocene governance. Furthermore, it helps to advance in the assessment of environmental inequality in societal models that prioritize economic growth to the detriment of socio‐environmental security.
Influence of Convective Heating Over the Maritime Continent on the West Antarctic Climate
Authors: Chen Jiaxin , Hu Xiaoming , Yang Song , Lin Shuheng , Li Zhenning 
Published: April 2022

AbstractThe Maritime Continent (MC) is regarded as an important heat source region and the impact of MC heating on the West Antarctic climate which is largely controlled by the Amundsen Sea Low (ASL) is unknown. This study is focused on the impact of intensified convective heating over the MC on the variation of the ASL in the austral fall. It is observed that enhanced MC heating is linked to deepening of the eastern ASL, a feature reproduced successfully by a model experiment in which additional heating is introduced to the MC. The intensified MC heating generates anticyclonic anomalies that result in a Rossby wave source in the upper troposphere to the south of MC. Then the Rossby wave originated from the new source propagates southeastward and deepens the eastern ASL. Additional model experiments prove that the response of ASL to MC heating is stronger than that to central Pacific cooling.
Ground‐Based Observation of a TGF Occurring Between Opposite Polarity Strokes of a Bipolar Cloud‐To‐Ground Lightning Flash
Authors: Kereszy I. , Rakov V. A. , Ding Z. , Dwyer J. R. 
Published: April 2022

AbstractWe present the ground‐based observation of a terrestrial gamma‐ray flash (TGF) that occurred between positive (second) and negative (third) strokes of a five‐stroke bipolar cloud‐to‐ground lightning flash. Those two strokes shared the same channel to ground at a distance of 200 m or so from the Lightning Observatory in Gainesville (LOG), Florida. Earlier TGF observations at ground level in Florida (a total of four) were either associated with the initial continuous current (ICC) of rocket‐triggered lightning flashes or occurred during the relatively steady current following the return‐stroke current peak in natural lightning flashes; that is, in the presence of current‐carrying channel to ground. The TGF presented here occurred in a different context: at the early (in‐cloud) stage of negative leader entering the remnants of the channel previously created by the positive stroke. The TGF had a duration of 35 μs and consisted of 18 pulses with amplitudes ranging from 114 to 912 keV. The overall flash context in which the TGF occurred was as follows. The first (143‐kA) stroke was negative and terminated on ground 1.4 km from LOG, the second (12‐kA) stroke was positive and forged a new path to ground about 200 m from LOG, and the third (28‐kA) stroke (TGF producer) was negative and followed the path of the second (positive) stroke. The fourth (43‐kA) stroke was negative and created a new termination on ground about 900 m from LOG, and the fifth (4.5‐kA) stroke was also negative and followed the fourth‐stroke channel.
Mechanisms of Reduced Mid‐Holocene Precipitation in Arid Central Asia as Simulated by PMIP3/4 Models
Authors: Wang Tao , Xu Hongna , Jiang Dabang , Yao Junqiang 
Published: April 2022

AbstractWe investigated the precipitation changes in mid‐latitude arid central Asia (ACA, including Central Asia and Xinjiang) and the related mechanisms in the mid‐Holocene using the output from the Paleoclimate Modeling Intercomparison Project phases 3 and 4 (PMIP3/4). The annual precipitation in ACA was decreased in the mid‐Holocene compared with the preindustrial period, consistent in direction with reconstruction records. Such change was mainly due to deficient winter and spring (December‐May) precipitation in the mid‐Holocene. The decrease in incoming solar radiation in the mid‐Holocene winter and spring caused stronger surface and tropospheric cooling in the northern low latitudes. It reduced the meridional temperature gradient in the troposphere, thereby weakening the westerly winds and related transport of water vapor. More importantly, the cooling weakened the local water cycle in ACA. Finally, the precipitation decreased over almost all of ACA. In the mid‐Holocene summer (June‐August), the meridional temperature gradient and related westerly winds were also reduced. It was mainly caused by stronger surface and tropospheric warming in the northern mid‐ to high latitudes. The stronger warming was due to increased summer incoming solar radiation in the mid‐Holocene. This process differed from that occurred in winter and spring. Therefore, the water vapor transport was weakened, and the summer precipitation was deficient in northern ACA. At the same time, strengthened descending motions contributed to the decrease in summer precipitation in most parts of Central Asia. On the contrary, intensified ascending motions increased summer precipitation in southeastern Xinjiang.
Energy Exchanges in Saturn's Polar Regions From Cassini Observations: Eddy‐Zonal Flow Interactions
Authors: Read Peter L. , Antuñano Arrate , Cabanes Simon , Colyer Greg , Gaztelurrutia Teresa del Río , Sanchez‐Lavega Agustin 
Published: April 2022

AbstractSaturn's polar regions (polewards of ∼63° planetocentric latitude) are strongly dynamically active with zonal jets, polar cyclones and the intriguing north polar hexagon (NPH) wave. Here we analyze measurements of horizontal winds, previously obtained from Cassini images by Antuñano et al. (2015), https://doi.org/10.1002/2014je004709, to determine the spatial and spectral exchanges of kinetic energy (KE) between zonal mean zonal jets and nonaxisymmetric eddies in Saturn's polar regions. Eddies of most resolved scales generally feed KE into the eastward and westward zonal mean jets at rates between 4.3 × 10−5 and 1.4 × 10−4 W kg−1. In particular, the north polar jet (at 76°N) was being energized at a rate of ∼10−4 W kg−1, dominated by the contribution due to the zonal wavenumber m = 6 NPH wave itself. This implies that the hexagon was not being driven at this time through a barotropic instability of the north polar jet, but may suggest a significant role for baroclinic instabilities, convection or other internal energy sources for this feature. The south polar zonal mean jet KE was also being sustained by eddies in that latitude band across a wide range of m. In contrast, results indicate that the north polar vortex may have been weakly barotropically unstable at this time with eddies of low m gaining KE at the expense of the axisymmetric cyclone. However, the southern axisymmetric polar cyclone was gaining KE from non‐axisymmetric components at this time, including m = 2 and its harmonics, as the elliptical distortion of the vortex may have been decaying.
Reticulon 2 promotes gastric cancer metastasis via activating endoplasmic reticulum Ca2+ efflux-mediated ERK signalling
Authors: Song Shushu , Liu Bo , Zeng Xiaoqing , Wu Yingying , Chen Hao , Wu Hao , Gu Jianxin , Gao Xiaodong , Ruan Yuanyuan , Wang Hongshan 
Published: April 2022

AbstractGastric cancer ranks fourth for mortality globally among various malignant tumours, and invasion and metastasis are the major reason leading to its poor prognosis. Recently, accumulating studies revealed the role of reticulon proteins in cell growth and transmigration. However, the expression and biological function of reticulon proteins in human gastric cancer remain largely unclear. Herein, we explored the potential role of reticulon 2 (RTN2) in the progression of gastric cancer. Tissue microarray was used to determine the expression levels of RTN2 in 267 gastric cancer patients by immunohistochemistry. Gastric cancer cell lines were utilised to examine the influences of RTN2 on cellular migration and invasion abilities, epithelial-to-mesenchymal transition (EMT) and signalling pathway. In vivo studies were also performed to detect the effect of RTN2 on tumour metastasis. We found that RTN2 expression was notably upregulated in tumour tissues compared to pericarcinomatous tissues. High RTN2 expression was positively correlated with patients’ age, vessel invasion, tumour invasion depth, lymph node metastasis and TNM stage. Besides, high RTN2 staining intensity was associated with adverse survival which was further identified as an independent prognostic factor for gastric cancer patients by multivariate analysis. And the predictive accuracy was also improved when incorporated RTN2 into the TNM-staging system. RTN2 could promote the proliferation, migration and invasion of gastric cancer cells in vitro and lung metastasis in vivo. Mechanistically, RTN2 interacted with IP3R, and activated ERK signalling pathway via facilitating Ca2+ release from the endoplasmic reticulum, and subsequently drove EMT in gastric cancer cells. These results proposed RTN2 as a novel promotor and potential molecular target for gastric cancer therapies.
The nuclear receptor REV-ERBα is implicated in the alteration of β-cell autophagy and survival under diabetogenic conditions
Authors: Brown Matthew R. , Laouteouet Damien , Delobel Morgane , Villard Orianne , Broca Christophe , Bertrand Gyslaine , Wojtusciszyn Anne , Dalle Stéphane , Ravier Magalie A. , Matveyenko Aleksey V. , Costes Safia 
Published: April 2022

AbstractPancreatic β-cell failure in type 2 diabetes mellitus (T2DM) is associated with impaired regulation of autophagy which controls β-cell development, function, and survival through clearance of misfolded proteins and damaged organelles. However, the mechanisms responsible for defective autophagy in T2DM β-cells remain unknown. Since recent studies identified circadian clock transcriptional repressor REV-ERBα as a novel regulator of autophagy in cancer, in this study we set out to test whether REV-ERBα-mediated inhibition of autophagy contributes to the β-cell failure in T2DM. Our study provides evidence that common diabetogenic stressors (e.g., glucotoxicity and cytokine-mediated inflammation) augment β-cell REV-ERBα expression and impair β-cell autophagy and survival. Notably, pharmacological activation of REV-ERBα was shown to phenocopy effects of diabetogenic stressors on the β-cell through inhibition of autophagic flux, survival, and insulin secretion. In contrast, negative modulation of REV-ERBα was shown to provide partial protection from inflammation and glucotoxicity-induced β-cell failure. Finally, using bioinformatic approaches, we provide further supporting evidence for augmented REV-ERBα activity in T2DM human islets associated with impaired transcriptional regulation of autophagy and protein degradation pathways. In conclusion, our study reveals a previously unexplored causative relationship between REV-ERBα expression, inhibition of autophagy, and β-cell failure in T2DM.
EGFR/MET promotes hepatocellular carcinoma metastasis by stabilizing tumor cells and resisting to RTKs inhibitors in circulating tumor microemboli
Authors: Song Shouyang , Yu Zhen , You Yajing , Liu Chenxi , Xie Xiaoyu , Lv Huanran , Xiao Feng , Zhu Qiang , Qin Chengyong 
Published: April 2022

AbstractThe receptor tyrosine kinases (RTKs) family is well-recognized as vital targets for the treatment of hepatocarcinoma cancer (HCC) clinically, whereas the survival benefit of target therapy sorafenib is not satisfactory for liver cancer patients due to metastasis. EGFR and MET are two molecules of the RTK family that were related to the survival time of liver cancer patients and resistance to targeted therapy in clinical reports. However, the mechanism and clinical therapeutic value of EGFR/MET in HCC metastasis are still not completely clarified. The study confirmed that EGFR/MET was highly expressed in HCC cells and tissues and the phosphorylation was stable after metastasis. The expression of EGFR/MET was up-regulated in circulating tumor microemboli (CTM) to accelerate IL-8 production and resistance to the lethal effect of leukocytes. Meanwhile, highly expressed EGFR/MET effectively regulated the Ras/MAPK pathway and stabilized suspended HCC cells by facilitating proliferation and inhibiting apoptosis. Moreover, EGFR/MET promoted phosphorylation of hetero-RTKs, which was dependent on high-energy phosphoric acid compounds rather than their direct interactions. In conclusion, highly expressed EGFR/MET could be used in CTM identification and suitable for preventing metastasis of HCC in clinical practice.
Suppressive effects of umbilical cord mesenchymal stem cell-derived exosomal miR-15a-5p on the progression of cholangiocarcinoma by inhibiting CHEK1 expression
Authors: Li Nuo , Wang Baoming 
Published: April 2022

AbstractCurrently, surgical extraction is the main therapy for cholangiocarcinoma (CCA) patients, but it’s highly susceptible to postsurgical complications and recurrence rate. Thus, we identified the suppressing roles of exosomal miR-15a-5p from umbilical cord mesenchymal stem cells (UCMSCs) in the EMT and metastasis of CCA. The microarray dataset GSE265566 was employed to determine the expression of CHEK1 in CCA tissues. The relationship of miR-15a-5p with CHEK1 was analyzed using bioinformatics tools and dual-luciferase reporter assay. The particle size of HUCMSCs-exo was detected by scanning electron microscopy and nanoparticle tracking analysis. The cellular and tumorous phenotypes were assessed through flow cytometry, CCK-8 assay, Transwell assay and the in vivo tumor xenograft experiments. CHEK1 was predicated to be markedly elevated in CCA. miR-15a-5p targeted CHEK1 and downregulated the expression of CHEK1. HUCMSCs-exo activated cell apoptosis but repressed the proliferative, invasive, and migratory potentials of CCA cells. After miR-15a-5p was silenced, HUCMSCs-exo presented an opposite effect in regulating CCA. Overexpression of miR-15a-5p promoted apoptosis but suppressed malignancy and tumorigenicity of CCA cells as well as EMT through downregulating CHEK1. Our data suggested that miR-15a-5p in HUCMSCs-exo suppresses EMT and metastasis of CCA through targeting downregulation of CHEK1.
Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation
Authors: Wang Chenfei , Chen Chuan , Liu Xiaoyu , Li Chong , Wu Qiu , Chen Xiaolan , Yang Lingyue , Kou Xiaochen , Zhao Yanhong , Wang Hong , Gao Yawei , Zhang Yong , Gao Shaorong 
Published: April 2022

AbstractChromatin remodeling is essential for epigenome reprogramming after fertilization. However, the underlying mechanisms of chromatin remodeling remain to be explored. Here, we investigated the dynamic changes in nucleosome occupancy and positioning in pronucleus-stage zygotes using ultra low-input MNase-seq. We observed distinct features of inheritance and reconstruction of nucleosome positioning in both paternal and maternal genomes. Genome-wide de novo nucleosome occupancy in the paternal genome was observed as early as 1 h after the injection of sperm into ooplasm. The nucleosome positioning pattern was continually rebuilt to form nucleosome-depleted regions (NDRs) at promoters and transcription factor (TF) binding sites with differential dynamics in paternal and maternal genomes. NDRs formed more quickly on the promoters of genes involved in zygotic genome activation (ZGA), and this formation is closely linked to histone acetylation, but not transcription elongation or DNA replication. Importantly, we found that NDR establishment on the binding motifs of specific TFs might be associated with their potential pioneer functions in ZGA. Further investigations suggested that the predicted factors MLX and RFX1 played important roles in regulating minor and major ZGA, respectively. Our data not only elucidate the nucleosome positioning dynamics in both male and female pronuclei following fertilization, but also provide an efficient method for identifying key transcription regulators during development.