bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of postoperative patient-prosthesis mismatch as a risk factor for early structural valve deterioration after aortic valve replacement with Trifecta bioprosthesis
Authors: Wakami Tatsuto , Koizumi Shigeki , Koyama Tadaaki 
Published: July 2022

Abstract
Background
Several studies have reported high rates of structural valve deterioration (SVD) in the Trifecta valves. Herein, we analyzed the midterm results of the Trifecta valve and risk factors for early SVD.

Methods
We retrospectively reviewed the records of 110 patients who had undergone Trifecta implantation between January 2012 and December 2017.

Results
We encountered seven cases of Trifecta valve failure. We performed a redo aortic valve replacement in five patients and a transcatheter aortic valve replacement in two patients. The SVD rate was 4.8% at 5 years and 6.6% at 7 years. The mean pressure gradient and peak velocity on the first postoperative echocardiogram in patients with SVD were higher than those in patients without SVD. The SVD rates with and without patient-prosthesis mismatch (PPM) were 2.8% and 12.6% at 5 years and 2.8% and 20.0% at 7 years. PPM is a risk factor for SVD. Noncoronary cusp tears were observed in all patients who had undergone redo surgery.

Conclusions
The most common cause of SVD was noncoronary cusp tear. Patients with PPM are at high risk of developing SVD.
An overview of “Chronic viral infection and cancer, openings for vaccines” virtual symposium of the TechVac Network - December 16-17, 2021
Authors: Isaguliants Maria G. , Trotsenko Ivan , Buonaguro Franco M. 
Published: July 2022

AbstractThis is a report on the research activities currently ongoing in virology, oncology and virus-associated cancers and possibilities of their treatment and prevention by vaccines and immunotherapies as outlined at the symposium “Chronic viral infection and cancer, openings for vaccines” virtually held on December 16–17, 2021. Experts from the various disciplines involved in the study of the complex relationships between solid tumors and viruses met to discuss recent developments in the field and to report their personal contributions to the specified topics. Secondary end point was to sustain the TECHVAC Network established in 2016 as a multidisciplinary work group specifically devoted to development of vaccines and immunotherapies against chronic viral infections and associated cancers, with the aim to identify areas of common interest, promote research cooperation, establish collaborative cross-border programs and projects, and to coordinate clinical and research activities.
Ultrasonographic measurements of the prostate gland in castrated adult dogs
Authors: Bosma Femke , Wijsman Saffiera , Huygens Simone , Passon-Vastenburg Maartje 
Published: July 2022

Abstract
Background
The dimensions of the prostatic gland in castrated adult dogs, as assessed by ultrasonography, is currently not yet reported in veterinary literature. The current study was aimed at reporting the prostatic dimensions in castrated dogs and investigate the relationship between the dogs’ body weight and prostate size. A second aim of the study was to investigate whether there was a relationship between the dogs’ age and prostate dimensions. A prospective, single-centre, observational study was conducted and 72 privately owned, adult, male castrated dogs with a range of breeds and ages met the final inclusion criteria. The subjects were divided into three categories based on body weight.

Results
A Kruskal–Wallis test found prostatic length and prostatic depth in the longitudinal orientation to be significantly different among the 3 categories (P < 0.005), with an increase in both prostatic length and prostatic depth with increasing body weight. Linear regression of the data set provided comprehensive formulas calculating prostatic length and depth based on the body weight of the dog (r2 of 0.69 and 0.53 for prostatic length and depth respectively). Kendall’s Tau rank test showed no correlation between dogs’ age and prostate dimensions (P > 0.100).

Conclusions
The current study is the first to provide a comprehensive, weight-based reference for the canine prostate gland of castrated dogs when assessed on ultrasonography.
Mobile rehabilitation support versus usual care in patients after total hip or knee arthroplasty: study protocol for a randomised controlled trial
Authors: Wang Qingling , Hunter Sharyn , Lee Regina Lai-Tong , Wang Xiaofeng , Chan Sally Wai-Chi 
Published: July 2022

AbstractBackgroundThe global increase in total hip or knee arthroplasty has led to concern about the provision of postoperative rehabilitation. Telerehabilitation may be a strategy to meet the patients’ requirements for rehabilitation after arthroplasty. This study aims to investigate the effectiveness of a telerehabilitation programme delivered via the mobile application WeChat in patients after total hip or knee arthroplasty on the following outcomes: self-efficacy, physical function, pain, depression, anxiety and health-related quality of life.MethodsThis is a single-centre, single-blinded, parallel-group, superiority randomised controlled trial conducted in Shanghai, China. Eighty-four eligible participants who undergo primary total hip or knee arthroplasty will be recruited preoperatively in a university teaching hospital and randomly assigned to the experimental or control group with their informed consent. Once discharged, the control group (n= 42) will receive the usual care provided by the hospital. The experimental group (n= 42) will receive usual care and a 6-week mobile application rehabilitation programme that consists of physical exercises and techniques for enhancing participants’ self-efficacy for rehabilitation. Baseline assessments will be conducted on the day before hospital discharge, and outcome assessments will be conducted 6 and 10 weeks postoperatively. The primary outcomes are changes in self-efficacy and physical function 6 weeks postoperatively, and the secondary outcomes include pain, depression, anxiety and health-related quality of life. The approach of a generalised estimating equation will be used to analyse the effect of the intervention on outcomes at a significance level of 0.05.DiscussionThis study is the first of its kind conducted in China to incorporate self-efficacy and learning theories as a framework to guide the development of a mobile application rehabilitation programme after arthroplasty. This study will contribute to the knowledge about the effectiveness of mobile application-based rehabilitation among patients after total hip or knee arthroplasty. If the findings are positive, they will support the implementation of mobile application-based rehabilitation in practice, which may potentially increase the accessibility of rehabilitation services as well as patient adherence to rehabilitation.Trial registrationAustralian New Zealand Clinical Trials RegistryACTRN12621000867897. Retrospectively registered on July 6, 2021
The antibacterial effect of nanosilver fluoride in relation to caries activity in primary teeth: a protocol for a randomized controlled clinical trial
Authors: Ammar Nour , El-Tekeya Magda M. , Essa Sara , Essawy Marwa M. , El Achy Samar N. , Talaat Dalia M. 
Published: July 2022

Abstract
Background
Minimally invasive dentistry is a highly convenient and efficient method of managing caries in pediatric patients. Silver diamine fluoride (SDF) is commonly used to arrest active caries lesions. However, the associated black stain, possibility of soft tissue injury, and unpleasant taste often limit its use. Recently, nanosilver fluoride (NSF) emerged as a promising topical fluoride agent with potent cariostatic and antibacterial potentials. This novel anticaries agent has gained attention as an alternative to overcome the drawbacks of SDF in caries arrest.

Objectives
To assess the antibacterial effect of NSF in relation to caries activity in dentin caries lesions, as well as to investigate the change in saliva bacterial levels in primary teeth in comparison to SDF after 1 and 3 months.

Materials and methods
Fifty children aged 4 to 6 years old with active dentin caries lesions (score 5 according to International Detection and Assessment System (ICDAS II) criteria) will be enrolled in the study. They will be equally and randomly allocated into 2 groups: a group receiving NSF and a control group receiving SDF treatment. Microbiological samples will be collected from the carious lesions and from unstimulated saliva at the baseline and at the 1 and 3 months’ follow-up appointments. Bacterial counts will be assessed using Mitis Salivarius agar (selective culture media for S. mutans) and Rogosa agar (selective culture media for lactobacilli), and the results will be expressed in colony-forming units. Data regarding the children’s oral health will be collected and their dmf index will be scored. The arrest of active carious lesions will be measured at the follow-up appointments according to ICDAS II criteria.

Results
The relation between bacterial colony counts and lesion activity for both groups will be assessed, as well as the change in salivary bacterial counts. The collected data will be statistically evaluated and tabulated. This clinical trial has been registered on ClinicalTrials.gov in January 2022 (original version) with ID: NCT05221749.
A prospective trial to evaluate the clinical efficacy and safety of neoadjuvant chemotherapy with arsenic trioxide and carboplatin in locally advanced cervical cancer: a study protocol for randomized controlled clinical
Authors: He Ze Yang , Li Hai Ying , Yan Jiao , Li Si Jin , Li Dao Cheng , Liang Zhong Zhe 
Published: July 2022

Abstract
Background
Cervical cancer is the fourth most common malignancy in women, which is threatening female reproductive tract health. Chemotherapy can be used for neoadjuvant therapy of locally advanced cervical cancer and postoperative adjuvant therapy for patients with high-risk factors, so as to reduce the focus, sensitize radiotherapy, and reduce recurrence. The current first-line treatment is paclitaxel combined with platinum. Many literature studies have found that As2O3 alone or in combination with platinum drugs have good efficacy in a variety of tumors both in vivo and in vitro. Moreover, our research group has verified that the efficacy of As2O3 combined with platinum drugs in the treatment of cervical cancer is not inferior to the traditional first-line regimen at the cellular and animal levels, and paclitaxel is more expensive than As2O3. Hence, we aim to evaluate the clinical efficacy and safety of neoadjuvant chemotherapy with As2O3 and carboplatin in locally advanced cervical cancer.

Methods
Sixty participants in the IB2, IIA2, and IIB stages of cervical cancer will be recruited in this study. After excluding patients who did not meet the criteria, they were randomly assigned to two groups in a 1:1 ratio. All patients underwent colposcopic biopsies to confirm the diagnosis and detailed clinical examinations. Eligible patients will receive either 2 cycles of paclitaxel and carboplatin or As2O3 and carboplatin every 3 weeks. Patients were assessed for clinical efficacy after the second cycle of chemotherapy. Patients who had disease stable or disease progression at these time points will receive concurrent chemotherapy and radiation directly, while responders will receive PiverRutledge grade III radical hysterectomy and bilateral pelvic lymphadenectomy. Both groups of patients undergoing radical hysterectomy were given adjuvant therapy as per protocol-defined criteria. The efficacy and toxicity of the two groups were evaluated according to WHO acute and subacute toxicity classification standards.

Discussion
This is the first single-center, prospective, two-arm design, open-label randomized control trial that will evaluate the clinical efficacy and safety of neoadjuvant chemotherapy with As2O3 and carboplatin in locally advanced cervical cancer.

Trial registration
ChineseClinicalTrialRegistryChiCTR1900023822. Registered on 13 June 2019.
Phosphodiesterase 5 inhibitor mirodenafil ameliorates Alzheimer-like pathology and symptoms by multimodal actions
Authors: Kang Byung Woo , Kim Fred , Cho Joon-Yong , Kim SangYun , Rhee Jinseol , Choung Jai Jun 
Published: July 2022

Abstract
Background
Alzheimer’s disease (AD) pathology is associated with complex interactions among multiple factors, involving an intertwined network of various signaling pathways. The polypharmacological approach is an emerging therapeutic strategy that has been proposed to overcome the multifactorial nature of AD by targeting multiple pathophysiological factors including amyloid-β (Aβ) and phosphorylated tau. We evaluated a blood-brain barrier penetrating phosphodiesterase 5 (PDE5) inhibitor, mirodenafil (5-ethyl-2-7-n-propyl-3,5-dihydrro-4H-pyrrolo[3,2-d]pyrimidin-4-one), for its therapeutic effects on AD with polypharmacological properties.

Methods
To evaluate the potential of mirodenafil as a disease-modifying AD agent, mirodenafil was administered to test its effects on the cognitive behaviors of the APP-C105 AD mouse model using the Morris water maze and passive avoidance tests. To investigate the mechanisms of action that underlie the beneficial disease-modifying effects of mirodenafil, human neuroblastoma SH-SY5Y cells and mouse hippocampal HT-22 cells were used to show mirodenafil-induced alterations associated with the cyclic guanosine monophosphate (cGMP)/cGMP-dependent protein kinase (PKG)/cAMP-responsive element-binding protein (CREB) pathway, apoptotic cell death, tau phosphorylation, amyloidogenesis, the autophagy-lysosome pathway, glucocorticoid receptor (GR) transcriptional activity, and the Wnt/β-catenin signaling.

Results
Here, mirodenafil is demonstrated to improve cognitive behavior in the APP-C105 mouse model. Mirodenafil not only reduced the Aβ and phosphorylated tau burdens in vivo, but also ameliorated AD pathology induced by Aβ through the modulation of the cGMP/PKG/CREB signaling pathway, glycogen synthase kinase 3β (GSK-3β) activity, GR transcriptional activity, and the Wnt/β-catenin signaling in neuronal cells. Interestingly, homodimerization and nuclear localization of GR were inhibited by mirodenafil, but not by other PDE5 inhibitors. In addition, only mirodenafil reduced the expression levels of the Wnt antagonist Dickkopf-1 (Dkk-1), thus activating the Wnt/β-catenin signaling.

Conclusions
These findings strongly suggest that the PDE5 inhibitor mirodenafil shows promise as a potential polypharmacological drug candidate for AD treatment, acting on multiple key signaling pathways involved in amyloid deposition, phosphorylated tau burden, the cGMP/PKG/CREB pathway, GSK-3β kinase activity, GR signaling, and the Wnt/β-catenin signaling. Mirodenafil administration to the APP-C105 AD mouse model also improved cognitive behavior, demonstrating the potential of mirodenafil as a polypharmacological AD therapeutic agent.
A symmetry-based length model for characterizing the hypersonic boundary layer transition on a slender cone at moderate incidence
Authors: Bi Wei-Tao , Wei Zhou , Zheng Ke-Xin , She Zhen-Su 
Published: July 2022

AbstractThe hypersonic boundary layer (HBL) transition on a slender cone at moderate incidence is studied via a symmetry-based length model: the SED-SL model. The SED-SL specifies an analytic stress length function (which defines the eddy viscosity) describing a physically sound two-dimensional multi-regime structure of transitional boundary layer. Previous studies showed accurate predictions, especially on the drag coefficient, by the SED-SL for airfoil flows at different subsonic Mach numbers, Reynolds numbers and angles of attack. Here, the SED-SL is extended to compute the hypersonic heat transfer on a 7 ∘ half-angle straight cone at Mach numbers 6 and 7 and angles of attack from 0 ∘ to 6 ∘. It is shown that a proper setting of the multi-regime structure with three parameters (i.e. a transition center, an after-transition near-wall eddy length, and a transition width quantifying transition overshoot) yields an accurate description of the surface heat fluxes measured in wind tunnels. Uniformly good agreements between simulations and measurements are obtained from windward to leeward side of the cone, implying the validity of the multi-regime description of the transition independent of instability mechanisms. It is concluded that a unified description for the HBL transition of cone is found, and might offer a basis for developing a new transition model that is simultaneously of computational simplicity, sound physics and greater accuracy.
Amplitude variation with incidence angle inversion of fluid parameters in porous media using an accurate estimation of the Jacobian matrix
Authors: Liu Xiaobo , Shen Guoqiang , Chen Jingyi 
Published: July 2022

Amplitude variation with incidence angle (AVA) or amplitude variation with offset (AVO) inversion provides remarkable information in discriminating lithology in hydrocarbon reservoirs. Fluid parameters (e.g., porosity, water, and oil saturations) are normally obtained through two steps and difficult to obtain from seismic data directly and accurately. Theoretically, the exact Zoeppritz equations and Biot-Gassmann equations can be combined together to invert fluid parameters using seismic data directly. We carry out AVA inversion to invert porosity, water, and oil saturations from seismic data using the exact Zoeppritz equations and accurate estimation of the Jacobian matrix. This matrix is composed of the partial derivatives of P- and S-wave reflection coefficients with respect to fluid parameters. Characteristics of these partial derivatives are analyzed. In addition, the iterative equations for AVA inversion are derived based on the Taylor series expansion. The numerical tests indicate that this algorithm can invert fluid parameters directly and accurately using seismic gathers. Unlike the conventional AVA using the approximations, the inversion using the exact Zoeppritz equations and accurate estimation of the Jacobian matrix is not limited by the selection of incidence angles and reflection interfaces. This method also is applicable to seismic data collected from formations with strong elastic contrast interfaces or large incidence angles.
Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis
Authors: Yang Jonathan T. , Wijetunga N. Ari , Pentsova Elena , Wolden Suzanne , Young Robert J. , Correa Denise , Zhang Zhigang , Zheng Junting , Steckler Alexa , Bucwinska Weronika , Bernstein Ashley , Betof Warner Allison , Yu Helena , Kris Mark G. , Seidman Andrew D. , Wilcox Jessica A. , Malani Rachna , Lin Andrew , DeAngelis Lisa M. , Lee Nancy Y. , Powell Simon N. , Boire Adrienne 
Published: July 2022

PURPOSEPhoton involved-field radiotherapy (IFRT) is the standard-of-care radiotherapy for patients with leptomeningeal metastasis (LM) from solid tumors. We tested whether proton craniospinal irradiation (pCSI) encompassing the entire CNS would result in superior CNS progression-free survival (PFS) compared with IFRT.PATIENTS AND METHODSWe conducted a randomized, phase II trial of pCSI versus IFRT in patients with non–small-cell lung cancer and breast cancers with LM. We enrolled patients with other solid tumors to an exploratory pCSI group. For the randomized groups, patients were assigned (2:1), stratified by histology and systemic disease status, to pCSI or IFRT. The primary end point was CNS PFS. Secondary end points included overall survival (OS) and treatment-related adverse events (TAEs).RESULTSBetween April 16, 2020, and October 11, 2021, 42 and 21 patients were randomly assigned to pCSI and IFRT, respectively. At planned interim analysis, a significant benefit in CNS PFS was observed with pCSI (median 7.5 months; 95% CI, 6.6 months to not reached) compared with IFRT (2.3 months; 95% CI, 1.2 to 5.8 months; P < .001). We also observed OS benefit with pCSI (9.9 months; 95% CI, 7.5 months to not reached) versus IFRT (6.0 months; 95% CI, 3.9 months to not reached; P = .029). There was no difference in the rate of grade 3 and 4 TAEs ( P = .19). In the exploratory pCSI group, 35 patients enrolled, the median CNS PFS was 5.8 months (95% CI, 4.4 to 9.1 months) and OS was 6.6 months (95% CI, 5.4 to 11 months).CONCLUSIONCompared with photon IFRT, we found pCSI improved CNS PFS and OS for patients with non–small-cell lung cancer and breast cancer with LM with no increase in serious TAEs.
The Impact of Supplements on Sports Performance for the Trained Athlete: A Critical Analysis
Authors: Kaufman Matthew W. , Roche Megan , Fredericson Michael 
Published: July 2022

Abstract
Elite athletes often use nutritional supplements to improve performance and gain competitive advantage. The prevalence of nutrient supplementation ranges from 40% to 100% among trained athletes, yet few athletes have a trusted source of information for their supplement decisions and expected results. This critical analysis review evaluates systematic reviews, meta-analyses, randomized control trials, and crossover trials investigating commonly used supplements in sport: caffeine, creatine, beta-alanine (β-alanine), branched chain amino acids (BCAAs), and dietary nitrates. By reviewing these supplements' mechanisms, evidence relating directly to improving sports performance, and ideal dosing strategies, we provide a reference for athletes and medical staff to personalize supplementation strategies. Caffeine and creatine impact power and high-intensity athletes, β-alanine, and BCAA mitigate fatigue, and dietary nitrates improve endurance. With each athlete having different demands, goals to maximize their performance, athletes and medical staff should collaborate to personalize supplementation strategies based on scientific backing to set expectations and potentiate results.
BLOOD FLOW CONDITION IN LOWER EXTREMITY VESSELS AND ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS DEPENDING ON DISEASE DURATION
Authors: Vinnik Yurii S. , Kochetova Lyudmila V. , Kulikova Anna B. 
Published: July 2022

The purpose of the study. Study arterial blood flow and blebbing of the plasma membrane of lymphocytes in the neuroischemic form of diabetic foot syndrome (SDS) depending on the age of the disease.
Material and methods. In a prospective study, 150 patients of type 2 DM were examined, of which 50 people with a neuroischemic form of SDS. Blood flow condition on vessels of lower extremities and plasma membrane of lymphocytes was examined. There were 30 women (60%), 20 men (40%). Vascular channel condition was evaluated by ultrasound dopplerography of lower extremity arteries, degree of diabetes mellitus compensation was determined by glycated hemoglobin level, lymphocyte membrane condition was evaluated by phase contrast microscope imaging results.
Results of the study. 72% of patients had complete occlusion of the tibia-foot segment of the arteries of the lower extremity, 28% had stenosis. The glycated hemoglobin level averaged 10.3 [8.5; 14.3]%, i.e. all observed patients had insufficient compensation for carbohydrate metabolism disorders. The total and terminal lymphocyte blebbing was 30.1 [25.4; 33.2]% and 15.8 [11.8; 18.4]%, which was 3 and 5 times higher than the control group, respectively. A high positive correlation between the duration of DM disease and the total (rS=0,72; p = 0.001) and terminal (rS=0,78; p = 0.001) blebbing of lymphocyte membrane.
Conclusion. The high correlation between the timing of DM disease and the blebbing of the lymphocyte plasma membrane allows these indicators to be used as markers of endothelial dysfunction in neuroischemic and ischemic forms of SDS. The level of summary and terminal blebbing can be considered as a prognostic marker of the development of macroangiopathy in patients with type 2 DM.