bluuebunny/crossref_metadata_2025_split huggingface dataset:
MODIFIED FMEA DALAM MANAJEMEN RISIKO RANTAI PASOK INDUSTRI BUDIDAYA LOBSTER AIR TAWAR
Authors: Khoiroh Siti Muhimatul 
Published: April 2022

Berkembangnya minat masyarakat Indonesia terhadap budidaya LAT (Lobster Air Tawar) merupakan salah satu efek dari peraturan pemerintah No. 56/ Permen-KP/2016. Sejak terjadinya pandemic Covid-19 dengan adanya pembatasan wilayah membuat salah satu industri budidaya LAT jenis Red Claw (Cherax Quadricarinatus) di area Sidoarjo Jawa Timur mengalami permasalahan dalam supply lobster kepada konsumen diberbagi daerah diluar kota di Indonesia. Keterlambatan pasokan lobster mengakibatkan keterlambatan pasokan bahan baku bagi konsumen yang mayoritas merupakan pegiat rumah makan atau restaurant.Keberhasilan manajemen rantai pasok ditentukan oleh besarnya biaya yang dapat diminimalisir, waktu yang singkat, dan kualitas yang terjaga, serta tingkat minimasi risiko(supply chain risk).Berdasarkan permasalahan yang terjadi, maka akan dilakukan identifikasi risiko pada setiap proses untuk melihat pengaruhnya terhadap biaya, waktu, dan kualitas. Kemudian dilanjutkan dengan penentuan bobot berdasarkan tingkat hambatan (severity), kemungkinan resistensi (occurrence), dan penyebab hambatan yang terdeteksi (detection). Langkah terakhir adalah menghitung nilai RPN (Risk Priority Number) yang diperoleh dari hasil keparahan.Dari hasil analisis identifikasi risiko dan perhitungan RPN dengan pendekatan FMEA, diperoleh bobot risiko tertinggi dengan nilai RPN 105 disebabkan oleh faktor risiko naiknya biaya distribusi hasil budidaya akibat dampak Pandemi Covid-19. Dengan demikian, perusahaan harus mempertimbangkan untuk mengatur ulang strategi bisnisnya untuk memfokuskan pada daerah-daerah yang dekat jangkauannya dengan titik lokasi supply lobster air tawar.
Hubungan Beban Kerja Mental Tenaga Kesehatan Dengan Patient Safety di Puskesmas Padongko Kabupaten Barru
Authors: Sabirin Nur Ainun , Nurfardiansyah Bur  , Yuliati  
Published: April 2022

Keselamatan pasien (patient safety) adalah pasien terbebas dari cedera yang seharusnya tidak terjadi atau bebas dari harm yang potensial akan terjadi terkait dengan pelayanan kesehatan. Penelitian ini bertujuan untuk mengetahui hubungan beban kerja mental tenaga kesehatan dengan patient safety di Puskesmas Padongko Kabupaten Barru. Jenis penelitian adalah penelitian kuantitatif dengan pendekatan cross sectional study. Sampel dalam penelitian ini sebanyak 84 responden sampel diambil dengan cara probability sampling dengan teknik proportionate strafied random sampling. Analisis data dilakukan secara univariat dan bivariat menggunakan uji chi square dengan derajat kemaknaan 0,05. Hasil analisis uji chi square menunjukkan bahwa tidak ada hubungan antara beban kerja mental dengan patient safety (p=0.170< α= 0,05), ada hubungan antara tuntutan kerja dengan patient safety (p=0.000 < α=0,05). Ada hubungan antara motivasi kerja dengan patient safety (p=0.017< α=0,05), ada hubungan kapasitas kerja dengan patient safety (p=0,001< α=0.05), dan ada hubungan indeks massa tubuh dengan patient safety (p=0,005< α=0.05). Disarankan perlu adanya tuntutan tugas sesuai kinerja, pemberian motivasi dengan pemberian reward kepada tenaga kesehatan, sehingga kapasitas kerja pegawai akan membaik sesuai dengan standar.
Los poderes probatorios del juez de amparo. Un garante de la corrección epistémica de los hechos
Authors: Osornio Plata Verónica Lorena 
Published: April 2022

<p> El artículo tiene como objetivo visibilizar la importancia de potenciar los poderes probatorios del juez en un medio de control constitucional, como lo es el juicio de amparo en México, en específico el relativo a la incorporación oficiosa de pruebas, en aras de fortalecer la averiguación de la verdad en el proceso. Así mismo, se pretende mostrar la insuficiencia de algunos argumentos que han obstaculizado el otorgamiento o el ejercicio de los poderes probatorios: la pérdida de imparcialidad judicial y la violación al principio de aportación de parte. Se advierte que dicho poder se prevé en la Ley de Amparo en supuestos limitados y que se tiene que recurrir a la codificación civil supletoria para regular su ejercicio, cuyo texto, en la práctica, restringe el principio de contradicción, en detrimento del derecho de defensa de las partes, por lo que es necesaria una reforma que subsane tales deficiencias e imponga límites a su actuación.</p>
KERISTENAN DI KOTA RAHA: 1909-1950
Authors: Samrila Lili , Fatma Fatma 
Published: April 2022

Masalah penelitian ini adalah: (1) Apa yang melatar belakangi kekristenan di Kota Raha pada 1909-1950? (2) Bagaimana perkembangan kekristenan di Kota Raha pada 1909-1950? (3) Apa saja dampak Kekristenan di Kota Raha pada 1909-1950? Metode yang digunakan dalam penelitian ini adalah metode sejarah yang terdiri dari lima tahap kegiatan yaitu, sebagai berikut: (1) Pemilihan Topik, (2) Heuristik Sumber, (3) Verifikasi Sumber, (4) Interpretasi Sumber, (5) Historiografi. Hasil penelitian menunjukkan bahwa: (1) Kekristenan di Kota Raha dilatarbelakangi oleh datangnya pastor P.I Onel sebagai langkah awal untuk memberikan pelayanan pada masyarakat yang kurang mampu berupa bantuan sandang dan pangan. Jalur penyebaran agama Kristen di pulau Muna berawal dari penyebaran ajaran Kristen oleh Pastor Asselberg yang menjadi pastor pertama di Makassar serta beberapa pembaptisan pada 1912 oleh seorang Putra dari David Salmon Pella, seorang pendiri organisator dan koordinator umat Katolik di Raha; (2) Perkembangan Agama Katolik di Kota Raha pada 1909-1942 terbagi menjadi tiga periode, yaitu (a) 1909-1930 saat Kristen Katolik diizinkan untuk melakukan misi di Pulau Muna, (b) 1942-1945 saat masa pendudukan Jepang, dan (c) 1945-1950 yang ditandai oleh penyebaran Kristen di luar Kota Raha melalui jalur pendidikan dan kesehatan; (3) Kekristenan di Kota Raha berdampak pada aspek sosial dan kebudayaan setempat.
PERJUANGAN MASSALINRI DAENG MALLIRA DALAM MENENTANG BELANDA DI KERAJAAN TELLU LIMPOE: 1861-1871
Authors: Yanti Yelda , Arman Arman 
Published: April 2022

Penelitian ini bertujuan untuk (1) Menjelaskan latar belakang masuknya Belanda di Kerajaan Tellu Limpoe, (2) Menjelaskan alasan Massalinri Daeng Mallira menentang Kolonial Belanda di Kerajaan Tellu Limpoe pada tahun 1861-1871, (3) Menjelaskan strategi Massalinri Daeng Mallira dalam menentang Kolonial Belanda di Kerajaan Tellu Limpoe. Penelitian ini menggunakan metode sejarah dengan tahapan-tahapan kerja sebagai berikut: (1) pemilihan topik, (2) pengumpulan sumber, (3) kritik sumber, (4) Interpretasi sumber, (5) Historiografi. Hasil penelitian menunjukkan bahwa (1) Belanda masuk di Sinjai pada tahun 1636 melalui ekspansi wilayah dengan menjalankan politik devide et impera (politik pecah belah). Kerajaan-kerajaan di Sinjai menentang upaya Belanda untuk memisahkan hubungan persatuan antarkerajaan yang ada di Sulawesi Selatan. Rakyat Sinjai tetap berupaya berpegang pada perjanjian Topekkong. Kolonial Belanda kemudian menyerang Kerajaan Tellu Limpoe dan berhasil menguasainya. Pasukan Sinjai pada masa itu dipimpin oleh Andi Mandasini dan Baso Kalaka pada tahun 1859. (2) Alasan Massalinri Daeng Mallira menentang Belanda di Kerajaan Tellu Limpoe karena tidak tahan dengan perlakuan Belanda terhadap rakyat Tellu Limpoe, selain karena faktor siri, faktor agama dan faktor ekonomi, Belanda juga menngganti sistem pemerintahan tradisional menjadi sistem pemerintahan Kolonial, mengadakan pemecatan raja-raja dan mengadakan pembuatan jalan yang dikerjakan oleh rakyat Tellu Limpoe dengan upah rendah, (3) Strategi yang ditempuh Massalinri Daeng Mallira dalam menentang Belanda di kerajaan Tellu Limpoe yakni bergerilya. Massalinri juga melakukan penyerangan selama tiga kali. Pada tahun 1863 perang yang dilakukan akhirnya menewaskan Raja Bulo-bulo yaitu Abd. Ganing yang diangkat oleh Belanda. Massalinri juga berhasil melumpuhkan pasukan Belanda dalam penyerangannya di Cakeppong. Penyerangan kedua dilakukan pada tahun 1870 dengan cara bergerilya dan berhasil melumpuhkan pasukan Belanda di tempat pangkalan militer yaitu di gerbang Benteng Balangnipa. Perang ketiga terjadi pada tahun 1871 dan merupakan akhir perjuangan Massalinri. Pada perang ketiga, pasukan Belanda berhasil melumpuhkan pasukan Massalinri dan menewaskan Massalinri Daeng Mallira tepatnya di Cappa Galung (diujung sawah) Bola Roman, Bikeru.
Infiltración linfocitaria tumoral como factor de buen pronóstico de supervivencia en pacientes con cáncer gástrico localmente avanzado
Authors: Castillo José , Caballero Henry , Tapia Verónica 
Published: April 2022

Introducción: La relación entre supervivencia e infiltración linfocitaria en el cáncer gástrico se ha determinado como factor pronóstico beneficioso, este estudio local tiene como objetivo determinar la probabilidad de supervivencia en los pacientes con cáncer gástrico estadios IB al IIIC de acuerdo con el porcentaje de infiltración linfocitaria.
Metodología: El presente estudio longitudinal se realizó en el Hospital Oncológico Solón Espinosa Ayala Solca-Núcleo de Quito. El período de estudio de enero del 2013 a enero del 2016, el tiempo de seguimiento terminó en diciembre del 2018. El cálculo muestral fue no probabilístico en donde se incluyeron casos de pacientes mayores a 18 años con diagnóstico de cáncer gástrico con estadios clínicos IB al IIIC, que contaron con una muestra histopatológica de gastrectomías. Se usó la variable: “Porcentaje de infiltración” para el análisis la muestra y se dividió en 3 grupos: G1: infiltración linfocitaria leve, G2: moderada y G3: intensa. Las estimaciones de supervivencia se calcularon utilizando el método de Kaplan-Meier y la comparación entre los grupos con la prueba log-rank.
Resultados: 173 pacientes con cáncer gástrico con estadios clínicos IB al IIIC, seguidos a 72 meses, el 60 % son hombres y el 40 % mujeres. Según el porcentaje de infiltración linfocitaria, el 52 % reportaron un porcentaje de infiltración leve, el 21 % moderada y el 27 % intensa. A los 72 meses de seguimiento la supervivencia en G1 fue del 31 %, en G2 fue del 48 %, y en G3 fue del 77 % (P= 0.001).
Conclusión: Se encontró que el grado de infiltración linfocitaria intensa en los pacientes con cáncer gástrico estuvo asociado a una mejor supervivencia en el seguimiento a 72 meses.
Assessment of Myocardial Microstructure in a Murine Model of Obesity-Related Cardiac Dysfunction by Diffusion Tensor Magnetic Resonance Imaging at 7T
Authors: Lohr David , Thiele Arne , Stahnke Max , Braun Vera , Smeir Elia , Spranger Joachim , Brachs Sebastian , Klopfleisch Robert , Foryst-Ludwig Anna , Schreiber Laura M. , Kintscher Ulrich , Beyhoff Niklas 
Published: April 2022

BackgroundObesity exerts multiple deleterious effects on the heart that may ultimately lead to cardiac failure. This study sought to characterize myocardial microstructure and function in an experimental model of obesity-related cardiac dysfunction.MethodsMale C57BL/6N mice were fed either a high-fat diet (HFD; 60 kcal% fat, n = 12) or standard control diet (9 kcal% fat, n = 10) for 15 weeks. At the end of the study period, cardiac function was assessed by ultra-high frequency echocardiography, and hearts were processed for further analyses. The three-dimensional myocardial microstructure was examined ex vivo at a spatial resolution of 100 × 100 × 100 μm3 by diffusion tensor magnetic resonance imaging (DT-MRI) at 7T. Myocardial deformation, diffusion metrics and fiber tract geometry were analyzed with respect to the different myocardial layers (subendocardium/subepicardium) and segments (base/mid-cavity/apex). Results were correlated with blood sample analyses, histopathology, and gene expression data.ResultsHFD feeding induced significantly increased body weight combined with a pronounced accumulation of visceral fat (body weight 42.3 ± 5.7 vs. 31.5 ± 2.2 g, body weight change 73.7 ± 14.8 vs. 31.1 ± 6.6%, both P &lt; 0.001). Obese mice showed signs of diastolic dysfunction, whereas left-ventricular ejection fraction and fractional shortening remained unchanged (E/e’ 41.6 ± 16.6 vs. 24.8 ± 6.0, P &lt; 0.01; isovolumic relaxation time 19 ± 4 vs. 14 ± 4 ms, P &lt; 0.05). Additionally, global longitudinal strain was reduced in the HFD group (−15.1 ± 3.0 vs. −20.0 ± 4.6%, P = 0.01), which was mainly driven by an impairment in basal segments. However, histopathology and gene expression analyses revealed no myocardial fibrosis or differences in cardiomyocyte morphology. Mean diffusivity and eigenvalues of the diffusion tensor were lower in the basal subepicardium of obese mice as assessed by DT-MRI (P &lt; 0.05). The three-dimensional fiber tract arrangement of the left ventricle (LV) remained preserved.ConclusionFifteen weeks of high-fat diet induced alterations in myocardial diffusion properties in mice, whereas no remodeling of the three-dimensional myofiber arrangement of the LV was observed. Obese mice showed reduced longitudinal strain and lower mean diffusivity predominantly in the left-ventricular base, and further investigation into the significance of this regional pattern is required.
High-Dimensional DNA Methylation Mediates the Effect of Smoking on Crohn’s Disease
Authors: Wang Tingting , Xia Pingtian , Su Ping 
Published: April 2022

Epigenome-wide mediation analysis aims to identify high-dimensional DNA methylation at cytosine–phosphate–guanine (CpG) sites that mediate the causal effect of linking smoking with Crohn’s disease (CD) outcome. Studies have shown that smoking has significant detrimental effects on the course of CD. So we assessed whether DNA methylation mediates the association between smoking and CD. Among 103 CD cases and 174 controls, we estimated whether the effects of smoking on CD are mediated through DNA methylation CpG sites, which we referred to as causal mediation effect. Based on the causal diagram, we first implemented sure independence screening (SIS) to reduce the pool of potential mediator CpGs from a very large to a moderate number; then, we implemented variable selection with de-sparsifying the LASSO regression. Finally, we carried out a comprehensive mediation analysis and conducted sensitivity analysis, which was adjusted for potential confounders of age, sex, and blood cell type proportions to estimate the mediation effects. Smoking was significantly associated with CD under odds ratio (OR) of 2.319 (95% CI: 1.603, 3.485, p &lt; 0.001) after adjustment for confounders. Ninety-nine mediator CpGs were selected from SIS, and then, seven candidate CpGs were obtained by de-sparsifying the LASSO regression. Four of these CpGs showed statistical significance, and the average causal mediation effects (ACME) were attenuated from 0.066 to 0.126. Notably, three significant mediator CpGs had absolute sensitivity parameters of 0.40, indicating that these mediation effects were robust even when the assumptions were slightly violated. Genes (BCL3 and FKBP5) harboring these four CpGs were related to CD. These findings suggest that changes in methylation are involved in the mechanism by which smoking increases risk of CD.
What Is Long-Term Survival and Which First-Line Immunotherapy Brings Long-Term Survival for Advanced Wild-Type Non-Small Cell Lung Cancer: A Network Meta-Analysis Based on Integrated Analysis
Authors: Zhang Xue , Xu Qian , Yu Xuejun , Huang Miao , Li Song , Sheng Lei , Dai Xin , Huang Kai , Wang Jian , Liu Lian 
Published: April 2022

BackgroundImmune checkpoint inhibitors (ICIs) have significantly improved survival for advanced wild-type non-small cell lung cancer, but there is no direct comparison to confirm which first-line treatment may lead to the longest overall survival. What qualifies as long-term survival (LS) is even unclear.MethodsBy searching PubMed, Embase, and the Cochrane Central Register of Controlled Trials from January 2005 to December 2020, we included randomized controlled trials (RCTs) of first-line ICI-containing treatments to perform an integrated analysis (IA) to determine the criterion of LS and then screened regimens with LS for network meta-analysis (NMA). The main outcomes for NMA were median overall survival (mOS), 1-year survival rate (1ySR), and 2-year survival rate (2ySR); those for IA were the pooled mOS (POS), 1ySR (P1SR), and 2ySR (P2SR).ResultsBy IA of 16 first-line ICIs from 20 RCTs, the POS was 16.20 (95% CI 14.79–17.60) months, with P1SR of 63% (95% CI 59–66%) and P2SR of 37% (33–41%). Thus, we defined LS as mOS ≥ POS (16.20 m) for regimens and screened for RCTs with outcomes meeting this criterion. Eleven ICI-based regimens can bring LS for the overall population, among which ICI with bevacizumab and chemotherapy achieved the longest POS of 19.50 m (16.90–22.10 m) and the highest P1SR (74%, 61%–87%) and P2SR (49%, 38%–61%). Pembrolizumab with chemotherapy ranked first in mOS and 1ySR, while atezolizumab plus bevacizumab and chemotherapy ranked first in 2ySR.ConclusionsThrough the IA of first-line treatment regimens, a POS of 16.20 m can be determined as the LS standard. Further considering 1ySR and 2ySR, atezolizumab combined with bevacizumab and chemotherapy or pembrolizumab plus chemotherapy are likely to bring the longest LS in the overall population, while single ICI may be adequate for patients with a high PD-L1 expression. ICIs with bevacizumab and chemotherapy may be the best combination for LS for its further advantage over time.
Validity of Machine Learning in Predicting Giant Cell Arteritis Flare After Glucocorticoids Tapering
Authors: Venerito Vincenzo , Emmi Giacomo , Cantarini Luca , Leccese Pietro , Fornaro Marco , Fabiani Claudia , Lascaro Nancy , Coladonato Laura , Mattioli Irene , Righetti Giulia , Malandrino Danilo , Tangaro Sabina , Palermo Adalgisa , Urban Maria Letizia , Conticini Edoardo , Frediani Bruno , Iannone Florenzo , Lopalco Giuseppe 
Published: April 2022

BackgroundInferential statistical methods failed in identifying reliable biomarkers and risk factors for relapsing giant cell arteritis (GCA) after glucocorticoids (GCs) tapering. A ML approach allows to handle complex non-linear relationships between patient attributes that are hard to model with traditional statistical methods, merging them to output a forecast or a probability for a given outcome.ObjectiveThe objective of the study was to assess whether ML algorithms can predict GCA relapse after GCs tapering.MethodsGCA patients who underwent GCs therapy and regular follow-up visits for at least 12 months, were retrospectively analyzed and used for implementing 3 ML algorithms, namely, Logistic Regression (LR), Decision Tree (DT), and Random Forest (RF). The outcome of interest was disease relapse within 3 months during GCs tapering. After a ML variable selection method, based on a XGBoost wrapper, an attribute core set was used to train and test each algorithm using 5-fold cross-validation. The performance of each algorithm in both phases was assessed in terms of accuracy and area under receiver operating characteristic curve (AUROC).ResultsThe dataset consisted of 107 GCA patients (73 women, 68.2%) with mean age ( ± SD) 74.1 ( ± 8.5) years at presentation. GCA flare occurred in 40/107 patients (37.4%) within 3 months after GCs tapering. As a result of ML wrapper, the attribute core set with the least number of variables used for algorithm training included presence/absence of diabetes mellitus and concomitant polymyalgia rheumatica as well as erythrocyte sedimentation rate level at GCs baseline. RF showed the best performance, being significantly superior to other algorithms in accuracy (RF 71.4% vs LR 70.4% vs DT 62.9%). Consistently, RF precision (72.1%) was significantly greater than those of LR (62.6%) and DT (50.8%). Conversely, LR was superior to RF and DT in recall (RF 60% vs LR 62.5% vs DT 47.5%). Moreover, RF AUROC (0.76) was more significant compared to LR (0.73) and DT (0.65).ConclusionsRF algorithm can predict GCA relapse after GCs tapering with sufficient accuracy. To date, this is one of the most accurate predictive modelings for such outcome. This ML method represents a reproducible tool, capable of supporting clinicians in GCA patient management.
Long-Term Effect of Acetylcholinesterase Inhibitors on the Dorsal Attention Network of Alzheimer’s Disease Patients: A Pilot Study Using Resting-State Functional Magnetic Resonance Imaging
Authors: Yamashita Ken-ichiro , Uehara Taira , Taniwaki Yoshihide , Tobimatsu Shozo , Kira Jun-ichi 
Published: April 2022

BackgroundAlzheimer’s disease (AD) is the most common condition of all neurodegenerative diseases and is characterized by various cognitive dysfunctions. Recent resting-state functional magnetic resonance imaging (rs-fMRI) studies have revealed the physiological dynamics of functionally connected brain networks, which are called resting-state networks (RSNs). Associations between impairments of RSNs and various neuropsychiatric diseases, such as AD, have been reported. Acetylcholinesterase inhibitors (AChEIs) have been used as a pharmacological treatment for mild-to-moderate moderate AD, and short-term improvements in cognitive functions and RSNs in restricted areas have been reported.ObjectiveWe aimed to characterize AChEI-related RSN changes by acquiring two sets of rs-fMRI data separated by approximately 3 to 6 months.MethodsSeventeen patients with AD and nine healthy subjects participated in this study. Independent component analysis was performed on the rs-fMRI data of AChEI-responsive and non-responsive AD patients, stratified according to change in Mini-Mental State Examination (MMSE) scores after 3 to 6 months of AChEI therapy. In addition, a region of interest-based analysis of the rs-fMRI data before therapy was performed to explore the functional connectivity (FC) changes associated with AchEI therapy.ResultsResponders showed a significantly greater increase in MMSE scores, especially for orientation for time, than that of non-responders following AChEI therapy. A subtraction map of MMSE score differences (responders minus non-responders) in the independent component analysis revealed higher FC of the dorsal attention network in responders compared with that in non-responders. Moreover, in the region of interest analysis of untreated status data, the dorsal attention network showed significant negative FC with the right planum temporale, which belongs to the ventral attention network, proportional to MMSE score change.ConclusionThe negative correlation of the FC of the dorsal attention network and right planum temporale before AChEI therapy and MMSE score change may be a biomarker of the therapeutic effect of AChEIs for AD.