bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring the Radioactivity Concentration of 40 K, 226 Ra, 232 Th and Radiological Risk Assessment from Water Tap
Authors: Salih Najeba F. 
Published: July 2022

Abstract
The water has an importance in environmental studies because of its daily usage by human and its ability to transport pollutants, such as radionuclides that can pose a health risk to human. The radiological quality of 226Ra, 232Th and 40K in some samples of water tap collected in kirkuk area, Iraq, has been measured by direct gamma ray spectroscopy using high purity germanium detector Result: or radium equivalent activity, internal hazard index (Hin), external hazard index (Hex),representative level index Iγr, Dose rate (nGyh-1),indoor and outdoorAnnual effective dose (AEDE) in the air,respectively, due to gamma radiation and the annual gonadal dose equivalent (AGDE) were calculated, it was lowerthe world average value 300μSv.y−1, recommended by UNSCEAR. Also, the values of radiation hazard expressed by (Raeq) varied from (223.2445 to 369.9037) mBq.kg−1 with a mean of 339.9506 mBq.kg−1 which is less, lower than the worldwide average. These values are far below the allowable limit (370 Bq.kg–1) recommended by the International Atomic Energy Agency (IAEA). And the calculated external hazard indices were found to be less than 1 which shows a low dose. These results can be contributed to the database of this area
Inter- and Intrarater Reliability of Short-term Measurement of Heart Rate Variability on Rest in Chronic Obstructive Pulmonary Disease (COPD).
Authors: Santos-de-Araújo Aldair Darlan , Bassi-Dibai Daniela , Camargo Patricia Faria , Marinho Renan Shida , Goulart Cássia da Luz , Dourado Izadora Moraes , Ricci Paula Angélica , Mendes Renata Gonçalves , Borghi-Silva Audrey 
Published: July 2022

Abstract
Individuals with COPD have an imbalance of cardiac autonomic control. In this context, HRV is considered an important tool for assessing cardiac sympathetic and parasympathetic balance, however it is a dependent evaluator measure and subject to methodological biases that may compromise the interpretation of results. This study examines the inter- and intrarater reliability of HRV parameters derived from short-term recordings in individuals with COPD. Fifty-one individuals of both genders with COPD clinical diagnosis confirmed by the pulmonary function test and aged ≥ 50 years were included. The RR interval (RRi) were recorded during a 10 min period on supine position using a portable heart rate monitor (Polar® H10 model). The data were transferred into Kubios® HRV Standard analysis software and analyzed within the stable sessions containing 256 sequential RRi. The intraclass correlation coefficient (ICC) ranged from 0.942 to 1.000 according to the intrarater analyse by Researcher 01 and 0.915 to 0.998 to the intrarater by Researcher 02. The interrater ICC ranged from 0.921 to 0.998. The coefficient of variation was up to 8.28 for Researcher 01 intrarater analysis, 9.06 for Researcher 02 intrarater analysis and 13.07 for interrater analysis. The measurement of HRV using a portable heart rate device in individuals with COPD present acceptable values of intra- and interrater reliability, supporting the use of HRV in the clinical and scientific scenario. Furthermore, it is important that the data analysis be performed by the same experienced evaluator.
Plasma cell myeloma with RAS/BRAF mutations: Clinicopathologic, molecular genetic features and outcomes of 68 patients
Authors: Li Nianyi , Lin Pei , Zuo Zhuang , You M. James , Shuai Wen , Orlowski Robert Z. , Manasanch Elisabet , Li Shaoying , Xu Jie , Garces Sofia , Jelloul Fatima Zahra , Tang Zhenya , Wang Wei , Medeiros L. , Yin C. Cameron 
Published: July 2022

Abstract
High-throughput genomic analysis of plasma cell myeloma has identified recurrent gene mutations of prognostic significance. Mutations in the RAS-MAPK pathway, such as KRAS, NRAS, and BRAF, are known as high-risk factors associated with poor prognosis in patients with various types of cancers, but studies in myeloma have yielded mixed results. We describe the clinicopathologic, cytogenetic, molecular features and outcomes of 68 patients with RAS/BRAF-mutated myeloma, and compare this group with 79 myeloma patients without any mutations. We show that KRAS, NRAS and BRAF were mutated in 16%, 11%, and 5% of cases, respectively. The RAS/BRAF-mutated group included 39 men and 29 women with a median age of 63 years (range, 35–82) at initial diagnosis. Patients with RAS/BRAF-mutated myeloma had lower hemoglobin and platelet counts, higher levels of serum lactate dehydrogenase and calcium, higher percentage of bone marrow plasma cells, and more advanced R-ISS stage. In addition, RAS/BRAF mutations were associated with complex karyotype and extra copies of CKS1B. The median overall survival and progression-free survival were significantly shorter for patients in the RAS/BRAF-mutated group (69.0 months vs 220.7 months, p = 0.0023 and 46.0 months vs 60.6 months, p = 0.0311, respectively). Univariate analysis revealed that KRAS mutation, NRAS mutation, lower hemoglobin level, elevated lactate dehydrogenase, higher R-ISS stage, complex karyotype, gain/amplification of CKS1B, monosomy 13/RB1 deletion and lack of autologous stem cell transplantation were associated with poorer prognosis. Multivariate analysis showed that KRAS mutation, lower hemoglobin level, higher level of serum calcium, higher ISS stage and lack of autologous stem cell transplantation predict inferior outcome. In summary, RAS/BRAF mutations occur in 30–40% of myeloma cases and are associated with higher tumor burden, higher R-ISS stage, complex karyotype, and shorter overall survival and progression-free survival. These findings support testing for RAS/BRAF mutations in myeloma patients and underscore the potential therapeutic benefits of RAS/BRAF inhibitors.
High-resolution terahertz digital holography based on frequency- domain diagonal extension imaging
Authors: Wang Yao , Li Qi 
Published: July 2022

Abstract
By leveraging frequency-domain diagonal extension (FDDE) imaging in terahertz (THz) in-line digital holography, the resolution of THz digital holography would be dramatically improved. The holography system in this work which utilizes a CO2-pumped 2.52 THz (118.83 µm) continuous-wave laser as the source and a pyroelectric-array camera with a pixel pitch of 100 µm as the detector could attain a resolution of 150 µm (∼1.26 λ) near to the resolution limit of the system. FDDE imaging is a simple and effective method for resolution enhancement, where no new detector or other equipment is employed. Samples are imaged twice from different angles and then the high-frequency components of images are stitched to improve the resolution. Different from the traditional FDDE, weight-FDDE (w-FDDE) which can reduce the visibility distinction between different orientations of the synthetic pictures by adding weight factors to produce a superior synthetic image is proposed in this work.
Real-life experience on the effectiveness of conjunctival flap and amniotic membrane graft in the treatment of refractory fungal corneal ulcer
Authors: Mahmuda Khadiza , Thakur Prof. Moshahid , Talukdar Paritush Kanti , Tanim Tawfique Enayeth , Chowdury Md. Kamrul Islam , Shanta Shamima , Afroz Mst Sabiha , Khan Md. Abdullah Saeed , Hasan Mohammad Jahid 
Published: July 2022

Abstract

Background: The study aimed to evaluate and compare the results of the conjunctival flap (CF) and cryopreserved amniotic membrane graft (AMG) in the management of fungal corneal ulcer with complications or non-responsive to medical treatment. Methods: In this retrospective study, medical records of 30 patients with culture-positive fungal corneal ulcer treated with either CF or AMG (15 eyes in each group) were retrieved for analysis. After the surgical procedure, patients were followed up at days 1, 7, 14, 21, 30, 60, 90, 120, and 180 to explore outcome of the operation along with complications.Results: Infecting fungi were Fusarium (n=11), Aspergillus (n=10), Mucor (n=4) and Penicillium (n=10). The most common indication was resistant ulcer with perforation. After the procedure, epithelization was completed in 11(73.33%) and 13 (86.67%) patients in the CF and AMG groups. Visual acuity improvement was significantly better in the latter group (CF: 1 [6.67%] vs. AMG: 7 [46.67%], p=0.023). Flap failure occurred in 4 patients (26.67%) from the CF and 2 (13.33%) from the AMG group. No significant differences were found between the two groups regarding success rate (p=0.651), epithelialization time (p=0.691), healing of corneal ulcer (p=0.651), and postoperative stability (p=0.651) of the flaps. Conclusions: CF and AMG are both effective for the management of refractory fungal corneal ulcers. However, AMG appears to improve visual acuity better than CF.
Modeling strength characteristics of hydrate-bearing sediments based on discrete element method
Authors: CHEN Yu-qi , Liu Lei , ZHOU Bo , XUE Shi-feng 
Published: July 2022

Abstract
It is indispensable for the natural gas hydrate exploration to evaluate the strength and deformation characteristics of hydrate-bearing sediments (HBS) and predict its strength and strain parameters. The main objective of this paper is to model the strength characteristics of HBS based on the discrete element method (DEM) simulation experiments. A preparation method is introduced to fabricate the DEM numerical samples of various HBS. A series of triaxial compression tests are operated on the HBS numerical samples with various conditions. The strength parameters of the HSB with various hydrate saturation and confining pressure, such as failure stresses, failure strains, cohesion and internal friction angles, are determined based on the test results. A strength model, which includes the failure stress evolution equation, the failure strain evolution equation, the cohesive evolution equation and the internal friction angle evolution equation, is developed to represent the strength characteristics of the HSB under various conditions. The cohesion evolution equation describes an exponential relationship between the cohesion and the hydrate saturation. While the internal friction angle evolution equation presents a linear relationship between the internal friction angle and the hydrate saturation. The failure stress evolution equations are based on Mohr-Coulomb criterion and modified Lade-Duncan criterion, respectively. Error analysis shows that the prediction of failure stress based on the modified Lade-Duncan criterion has the higher accuracy. The failure strain evolution equation is based on Mohr-Coulomb criterion, and it has a good performance.
Pathological complete response to neoadjuvant chemotherapy in triple negative breast cancer - one clinic experience.
Authors: Sivina Elina , Blumberga Lubova , Purkalne Gunta , Irmejs Arvids 
Published: July 2022

Abstract
Background. Triple negative breast cancer is heterogeneous BC molecular subtype. Pathological complete response (pCR) is important surrogate marker for progression free and overall survival. Aim of study was to evaluate clinical and pathological factors that are associated with complete pathological response status in triple negative breast cancer receiving neoadjuvant chemotherapy. Materials and methods. 80 triple negative breast cancer patients who underwent neoadjuvant chemotherapy followed by surgery in Pauls Stradins Clinical University Hospital between January 2018 and January 2020 were retrospectively analyzed. 27 patients (33.7%) were BRCA founder mutation carriers. Results. 32.5% (n=26) patients in all study group and 55.6% (n=15) in patients with BRCA founder mutation achieved pCR. 47 of all patients received platinum-based neoadjuvant chemotherapy, 19 patients (40.4%) achieved complete pathological response. Patients in pCR group presented with significantly higher Ki-67 score (p=0.007), BRCA 1 or 2 mutation (p=0.002) and younger age (p=0.02) than in non-pCR group. pCR did not statistically significantly impact RFS and OS. Conclusions. BRCA mutation, Ki67 score and age are predictive factors for response to neoadjuvant chemotherapy in triple negative breast cancer.
Lysinibacillus macrolides 38328 Isolated from Agricultural Soils as a Promising Probiotic Candidate for Intestinal Health
Authors: Chen Huinan , Sun Xiaoyi , He Huilin , Ren Hongkun , Duan Haoyuan , Zhang Chuankun , Chang Qingru , Zhang Runxiang , Ge Junwei 
Published: July 2022

Abstract
There is an increasing interest in the use of spore-forming Bacillus spp. as probiotic ingredients on the market. However, probiotics Bacillus species are insufficient, and more safe Bacillus species were required. In the study, traditional fermented foods and soil samples were collected from all over the country in China, and 506 Bacillus were selected from 109 samples. Using the optimized procedure, we screened 9 strains, which successfully passed the acid, alkali, bile salt and trypsin resistance test. Drug sensitivity test results showed that three Bacillus out of the 9 isolates exhibited antibiotic sensitivity to more than 29 antibiotics. The 3 strains sensitive to antibiotics were identified by 16S ribosomal RNA analysis, two isolates (38327 and 38328) belong to the specie Lysinibacillus macrolides and one isolate (37326) belong to Bacillus halotolerans. Moreover, the 3 strains were confirmed safe through animal experiments. Finally, L. macrolides 38327 and 38328 showed the protection in Salmonella infection mouse model, which manifested in slowing down weight loss, reducing bacterial load, improving antioxidant capacity. Altogether, our data demonstrate selected L. macrolides strains can be used novel probiotics for intestinal health.
Integrated interpretation of most positive and most negative curvature of ground gravity data across the Shillong plateau and Mikir hills periphery, north-east India
Authors: Ghosh Gopal K. 
Published: July 2022

Abstract
The study area falls in one of the utmost seismically vigorous zones covering latitude 23°–28°N and longitude 88°–96°E in the north-eastern part of India. Various studies suggest that tectonic activities are still active across the Shillong plateau, Mikir hills, Arakan-Yoma fold belt, Naga hills, parts of Bengal basin, lower-upper Brahmaputra valley along with the Mishmi hills of Himalayan foothills. The available information about the thrust-faults in the area is very limited and most of the information are available from the geographic information system map, field geological studies and very limited from seismic and other data sources. In this present study, attempt has been made to carry out details study of most positive and most negative curvature attributes for understanding sub-surface structural features and able to identify structural lineament/thrust-fault in the study area using available ground gravity data in the north-eastern part of India. Further, present studied results are correlated and compared with the past derived results of three-dimensional Euler source depth locations and source edge estimations in this area. The integrated results of the curvature interpretation look promising and can able to delineate the thrust–fault locations. This paper also suggests additional new thrust-fault lineament information. As the gravity data has its own constraint hence integrated study can help to provide for better geoscientific information.
Pseudomonas aeruginosa pulmonary infection results in S100A8/A9-dependent cardiac dysfunction
Authors: Rajaram Murugesan , Kumar Naresh , Pestrak Matthew , Wu Qian , Ahumada Omar Santiagonunez , Dellos-Nolan Sheri , Saljoughian Noushin , Shukla Rajnikant , Mitchem Cortney , Nagareddy Prabhakara , Ganesan Latha Prabha , Lafuse William , Wozniak Daniel 
Published: July 2022

Abstract
Pseudomonas aeruginosa (P.a.) infection accounts nearly 20% of all cases of hospital acquired pneumonia with mortality rates > 30%. P.a. infection induces a robust inflammatory response, which ideally enhances bacterial clearance. Unfortunately, excessive inflammation can also have negative effects, and often leads to cardiac dysfunction with associated morbidity and mortality. However, it remains unclear how P.a. lung infection causes cardiac dysfunction. Using a murine pneumonia model, we found that of P.a. infection of lungs led to severe cardiac left ventricular dysfunction and electrical abnormalities. More specifically, we found that neutrophil recruitment and release of S100A8/A9 in the lungs activates the TLR4/RAGE signaling pathways, which in turn enhance systemic inflammation and subsequent cardiac dysfunction. Paradoxically, global deletion of S100A8/A9 did not improve but aggravated cardiac dysfunction and immortality likely due to uncontrolled bacterial burden in the lungs and heart. Our results indicate that P.a. infection induced release of S100A8/9 is double-edged, providing increased risk for cardiac dysfunction yet limiting P.a. growth.
Long-Term Outcome of Cohen Vs. Gil-Verent Methods in The Treatment 0f Vesicoureteral Reflux
Authors: Hosseini Seyedeh Elnaz , mahdavynia Soheila , Hooman Nakysa , Jahangiri Fariba , Nasiri Seyyed Javad , Otoukesh Hasan , Hosseini Rozita , Nickavar Azar 
Published: July 2022

Abstract
Introduction: The vesicoureteral reflux (VUR) is among the most common congenital disorder of urinary system. There are several surgical methods to manage this disease. In this study we aimed to assess and compare the result of the two common surgical techniques including Cohen and Gil-Vernet methods of in children with VUR.Method and materials: In this retrospective study, we gathered the record of all patients who underwent Cohen or Gil-Vernet surgeries during 2010-2017. We recruited all the infants and patients until age of 15 years who had moderate and high grade VUR in voiding cystourethrogram (VCUG). We gathered and compared information regarding the grade of VUR, the number of breaks through urinary tract infection (UTI), kidney parenchymal scars and the side effects of surgery between two methods. Results: In this study we recruited 89 patients with mean age of 66.56 ± 31.51months. Of all patients, 18 cases underwent Cohen surgery and for 71 patients Gil-Vernet was performed. All the patients showed improvement regarding the grade of reflux according to VCUG (p:.001). The incidence rate of UTI was decreased in both groups (p:0.001). The clinical profile of the study participants was improved in both group and there was not any difference between two surgical modalities in this respect. The mean follow-up time was 59.11 ± 23.4 months.Conclusion: Both Cohen or Gil-Vernet surgeries were effective methods for treating VUR. Also, there was not any significant difference between two surgical techniques.
Overexpression of legumain and matrix metallopeptidase-9 in peripheral blood mononuclear cells are associated with the severity of coronary artery stenosis
Authors: Sedehi Ameneh Zamani , Samani Keihan Ghatreh , Khaledifar Arsalan , Mohseni Roohollah 
Published: July 2022

Abstract
Aims
The deregulation of cellular and molecular events in peripheral blood mononuclear cells (PBMCs) may have contributed to the pathogenesis of atherosclerosis. We investigated the alteration of the expression of legumain and matrix metallopeptidase-9 (MMP-9) in PBMCs of subjects who underwent angiography.
Main methods:
Following a thorough clinical examination and anthropometric assessments, 90 individuals were divided into two groups: 56 CAD participants (subjects with coronary artery stenosis ≥ 50%) and 34 Non-CAD participants (subjects with coronary artery stenosis ≤ 30%). Fasting blood sugar (FBS), total cholesterol (Chol), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and triglyceride cholesterol (TG) were evaluated. The severity of coronary artery stenosis was recorded. Additionally, Real-time PCR was used to assess the gene expression of legumain and MMP-9. Legumain and MMP-9 protein levels were also assessed using enzyme-linked immunosorbent assay (ELISA) and western blot techniques, respectively.
Key findings:
Elevated FBS was positively associated with the increased expression of legumain and coronary artery stenosis. Our results revealed that legumain and MMP-9 were upregulated both at the level of transcription and translation. Moreover, the upregulation of legumain and MMP-9 had a significant positive correlation with the severity of coronary artery stenosis.
Significance:
Our hypothesis that upregulation of involved extracellular proteases such as legumain and MMP-9 in PBMCs plays a significant role in the pathogenesis of atherosclerosis before monocyte recruitment and its subsequent processes was confirmed by the significant correlation of overexpression legumain and MMP-9 with coronary artery stenosis.
Proteomics data reveals Wnt signaling involvement in the hippocampal-dependent behavioral impairment in THRSP-overexpressing attention-deficit/hyperactivity disorder mouse model
Authors: Custodio Raly James , Kim Hee Jin , Kim Jiyeon , Ortiz Darlene Mae , Kim Mikyung , Buctot Danilo , Sayson Leandro Val , Lee Hyun Jun , Kim Bung-Nyun , Yi Eugene , Cheong Jae Hoon 
Published: July 2022

Abstract
Despite the predominance and high heritability of attention-deficit/hyperactivity disorder (ADHD), its etiology remains unclear. Preclinical and clinical evidence partially implicates impaired limbic system function, particularly in the hippocampus (HPC). Children diagnosed with ADHD often struggle with deficits in executive function, temporal processing, and visuospatial memory, the defining hallmarks of the predominantly inattentive presentation (ADHD-PI), which is subserved by the hippocampus. However, the specific genes/proteins involved and how they shape hippocampal structure to influence ADHD behavior remain poorly understood. As an exploratory tool, hippocampal tissues from a mouse model overexpressing (OE) thyroid hormone-responsive protein (THRSP) with defining characteristics of ADHD-PI were utilized for proteomic analyses. Integrated proteomics and network analysis revealed altered protein network involved in Wnt signaling. Compared with THRSP knockout (KO) mice, THRSP OE mice showed impaired attention and memory, accompanied by dysregulated Wnt signaling affecting hippocampal cell proliferation (BrdU) and neurogenic marker expression (i.e., NEU-N, GFAP), markers of neural stem cell (NSC) activity. In addition, combined exposure to an enriched environment and treadmill exercise could improve behavioral deficits in THRSP OE mice and Wnt signaling and NSC activity.
Artificial Intelligence-Based Traffic Flow Prediction: A Comprehensive Review
Authors: Sayed Sayed A. , Abdel-Hamid Yasser , Hefny Hesham Ahmed 
Published: July 2022

Abstract
The expansion of the Internet of Things has resulted in new creative solutions, such as smart cities, that have made our lives more productive, convenient, and intelligent. The core of smart cities is the Intelligent Transportation System (ITS) which has been integrated into several smart city applications that improve transportation and mobility. ITS aims to resolve traffic issues, especially traffic congestion. Recently, new traffic flow prediction models and frameworks have been rapidly developed in tandem with the introduction of Artificial Intelligence (AI) approaches to improve the accuracy of traffic flow prediction. Traffic forecasting is a crucial duty in the transportation industry. It can significantly affect the design of road constructions and projects in addition to its importance for route planning and traffic rules. Furthermore, traffic congestion is a critical issue in urban areas and overcrowded cities. Therefore, it must be accurately evaluated and forecasted. Hence, a reliable and efficient method for predicting traffic is essential. The main objectives of this study are: First, present a comprehensive review of the most popular machine learning and deep learning techniques applied in traffic prediction. Second, identifying inherent obstacles to applying machine learning and deep learning in the domain of traffic prediction.