bluuebunny/crossref_metadata_2025_split huggingface dataset:
Giovanni Alfonso Borelli’s Last Will (1679, December 31st)
Authors: Favino Federica 
Published: March 2022

Abstract
The paper provides an annotated edition of the original copy of the last will by the mathematician, physicist, and astronomer Giovanni Alfonso Borelli (1608–1679), discovered among the papers of the Curia of the Cardinal Vicary, kept in the State Archives of Rome. Up until now, the document was known only through the incomplete copy guarded in the General Archives of the Piarists religious Order—Borelli’s sole heir—at the General House of San Pantaleo in Rome. The testament was found during the implementation of the Horizon 2020 Borelli Galaxy project (2018–2021, www.borgal.eu), aimed at editing a unified electronic catalogue of Borelli’s correspondence and to use his letters as a source of data suitable to map and chart Borelli’s overlapping intellectual, social, and political networks. The will is treated here as a “socio-text,” that is, as a freeze-frame of Borelli’s networks in his last years in Rome. By coding and processing—through the web infrastructure Nodegoat and the relational modes of analysis it provides—the interactions between Borelli and his heirs and legatees, as well as the interactions that occurred among his legatees outside this scope, the paper tries to reconstruct and visualize the social structure of this network, to single out Borelli’s place within that complex system, as well as to figure out its genesis. Compared with Borelli’s contemporary correspondence, this data also offers a glimpse into his later editorial choices.
The genus Raysymmela Saylor, 1947 (Coleoptera, Scarabaeidae, Melolonthinae, Sericini): taxonomy and phylogenetic analysis
Authors: Pacheco Thaynara L. , Wipfler Benedict , Monné Marcela L. , Ahrens Dirk 
Published: March 2022

Abstract
Here we revise the taxonomy of the South American genus Raysymmela Saylor, 1947 and perform a phylogenetic analysis based on 126 morphological characters. We propose one new synonym, Raysymmela pallipes (Blanchard, 1850) (= Symmela boliviensis Moser, 1919 syn. n.), and three new combinations, Raysymmela costaricensis (Moser, 1924) comb. n., Raysymmela seticollis (Moser, 1921) comb. n., and Raysymmela varians (Erichson, 1847) comb. n. Two new species are described: Raysymmela equatorialis sp. n. (Ecuador) and R. erwini sp. n. (Bolivia). Lectotypes of following taxa were designated: Symmela boliviensis Moser, 1919, S. bruchi Moser, 1924, S. costaricensis Moser, 1924, S. curtula Erichson, 1835, S. pallipes Blanchard, 1850, S. seticollis Moser, 1921, and S. varians Erichson, 1847. Species are redescribed and a key to species is given, external morphological features as well as aedeagus are illustrated for all taxa. Distribution maps as well as a key to currently known South American genera of Sericini are provided. From phylogenetic analysis using parsimony, Raysymmela is not recovered as monophyletic.
Subjective cognitive decline, APOE e4 allele, and the risk of neurocognitive disorders: Age- and sex-stratified cohort study
Authors: Liew Tau Ming 
Published: March 2022

Objective: Subjective cognitive decline and APOE e4 allele (APOE4) are known predictors of mild cognitive impairment and dementia (mild cognitive impairment/dementia), with recent evidence showing interaction between subjective cognitive decline and APOE4 in amplifying the risk of mild cognitive impairment/dementia. However, the literature is unclear whether the interaction effect is seen across various age and sex strata. This study examined the interaction between subjective cognitive decline and APOE4—across different age and sex strata—on the risk of mild cognitive impairment/dementia. Methods: This cohort study included 16,221 participants aged ⩾50 years and had normal cognition at baseline. Participants were evaluated for subjective cognitive decline and APOE4 at baseline, and followed-up almost annually for mild cognitive impairment/dementia (median follow-up = 4.5 years). Interaction effects were examined in Cox regression using Relative Excess Risk due to Interaction, stratified by age (⩽70 vs >70 years) and sex. Results: Subjective cognitive decline and APOE4 were independently associated with mild cognitive impairment/dementia (hazard ratio: 1.4–1.8), with the highest risk when subjective cognitive decline and APOE4 co-occurred (hazard ratio: 2.6). APOE4 amplified the association between subjective cognitive decline and mild cognitive impairment/dementia in older women (Relative Excess Risk due to Interaction 1.0; 95% confidence interval = [0.3, 1.6]), but not in other age or sex strata. Among older women, half of them developed mild cognitive impairment/dementia by 12.1 years in the absence of subjective cognitive decline or APOE4. This duration shortened to 8.1–10.3 years in the presence of either subjective cognitive decline or APOE4, and to 4.4 years in the presence of both subjective cognitive decline and APOE4. Interaction effect among older women remained consistent when alternate outcomes were used (i.e. mild cognitive impairment and dementia due to Alzheimer’s disease; dementia; and Alzheimer’s dementia) (Relative Excess Risk due to Interaction 1.2–2.5). Conclusions: APOE4 amplifies the association between subjective cognitive decline and neurocognitive disorders in older women, with the findings suggesting the need for further research to delineate underlying neurobiology. APOE4 may potentially have a role in facilitating further risk stratification of older women with subjective cognitive decline in clinical practice.
Trends of perinatal mental health referrals and psychiatric admissions in Queensland
Authors: San Martin Porter Macarena A , Maravilla Joemer , Kisely Steve , Betts Kim S , Salom Caroline , Alati Rosa 
Published: March 2022

Background: Perinatal depression is often underdiagnosed; consequently, many women suffer perinatal depression without follow-up care. Screening for depressive symptoms during the perinatal period has been recommended in Australia to increase detection and follow-up of women suffering from depressive symptoms. Screening rates have gradually increased over the last decades in Australia. Objective: To explore trends in referrals of women to community mental health services during the perinatal period, and prenatal and postnatal admissions to psychiatric units, among those who gave birth in Queensland between 2009 and 2015. Method: Retrospective analyses of data from three linked state-wide administrative data collections. Trend analyses using adjusted Poisson regression models examined 426,242 births. Outcome variables included referrals to specialised mental health services; women admitted with a mood disorder during the second half of their pregnancy and during the first 3 months of the postnatal period; and women admitted with non-affective psychosis disorders during the second half of their pregnancy and during the first 3 months of the postnatal period. Results: We found an increase in mental health referrals during the perinatal period over time (adjusted incidence rate ratio, 1.07; 95% confidence interval, [1.06, 1.08]) and a decrease in admissions with mood disorders during the first 3 months of the postnatal period (adjusted incidence rate ratio, 0.95; 95% confidence interval, [0.94, 0.98]). We did not find any changes in rates of admission for other outcomes. Conclusion: Since the introduction of universal screening in Queensland, referrals for mental health care during the perinatal period have increased, while admissions for mood disorders in the first 3 months after delivery decreased.
The Production of Neoliberal Subjectivity in an Argentine Public University
Authors: Barboza Romina Andrea 
Published: March 2022

Argentina’s public university system has shifted from the indelible reformist tradition of 1918, with its emancipatory and Latin American perspective, to a commodified education in line with the global logic introducing neoliberal rationality and the neoliberal subject into the Universidad Nacional de Cuyo. A review of recent reforms and a description of the university’s institutional measures is followed by possible lines of resistance, combining ideas from the 1918 reformist movement and the current Argentine feminist movement. La universidad pública argentina está sufriendo una conversión de la tradición de indeleble marca reformista desde 1918 (de horizonte emancipatorio y latinoamericano) a una educación mercantilizada según la lógica global de la racionalidad neoliberal y del sujeto neoliberal, visible en la Universidad Nacional de Cuyo. Repaso reformas nacionales recientes, y describo las disposiciones institucionales de la universidad para llegar a una discusión sobre coordenadas posibles de resistencia entrecruzando ideas del movimiento reformista de 1918 y el actual movimiento feminista argentino.
A study on universal round trip time analysis for passenger demand beyond elevator contract capacity by Monte Carlo simulation
Authors: So Albert T. 
Published: March 2022

The traditional elevator system design practice is to calculate the round trip time (RTT) and associated parameters of pure incoming traffic during up-peak, followed by real-time computer simulation. Recent studies indicated that the normal traffic is much more complicated, consisting of a mixture of incoming, outgoing and interfloor patterns. A major breakthrough to analytically calculate the Universal RTT, under such complicated traffic patterns, emerged 6 years ago based on an appropriate origin-destination matrix describing the passenger transit probability. That genesis model played safe by assuming that the total number of passengers demanding service within one round trip is limited elevator contract capacity, which is in line with the traditional up-peak incoming RTT formulae. In this article, such assumption is removed and the study is based on Monte Carlo simulation. It is found that there is room for enhancing the handling capacity, up to two times the contract capacity, by not sacrificing the RTT and average passenger transit time by too much. This phenomenon, that is, total passenger demand beyond contract capacity, is only valid under the existence of multiple entrance floors and/or mixed traffic conditions. This approach may prevent oversizing the design which could be more realistic. Practical applications: Elevator system designers, according to ISO 8100:32:2020 and CIBSE Guide D: 2020, are recommended to carry out calculation of the RTT and related parameters before any real-time computer simulation. This practice has been adopted by the elevator industry for decades. However, conventional RTT evaluation is mainly on pure incoming traffic during up-peak. The Universal RTT calculation method developed in 2014–15 extended RTT evaluation to cover dominant and complicated traffic patterns of modern buildings, but the assumed number of passengers to be handled within one round trip was limited to the contract capacity of the elevator. This article further removes this limitation to evaluate the limit of handling capacity with reasonable RTT and average passenger transit time. Then, the Universal RTT method could be more realistic and rolled out, and prevent oversizing the system design.
The safe evacuation of persons from a building operating within COVID-19 restrictions
Authors: Brzezińska Dorota , Barański Mariusz , Bryant Paul , Haznar-Barańska Agnieszka 
Published: March 2022

Buildings’ environmental conditions were changed drastically around the world due to the COVID-19 pandemic hazards and restrictions. New social distance rules and organizational changes in the buildings appeared to require a modified fire safety evacuation analysis. The total number of building users under the revised requirements was often limited. Some additional restrictions, such as the reduction of evacuation exit availability, could cause escape problems in the case of fire. In order to determine how the pandemic restrictions could influence the evacuation conditions, a sports hall building was used to assess the impact of the restrictions on evacuation strategies. The research covered test evacuation simulations using the ‘Pathfinder’ modelling software, as well as manual calculations of the expected evacuation time. It was found that the pandemic social distance requirements could cause adverse evacuation conditions in the case of fire. The research helped formulate a simple mathematical algorithm for determining safety evacuation parameters under pandemic restrictions. Practical application The surrounding conditions for new buildings are driven by the reduction of social distances imposed by the COVID-19 pandemic. It has been found that pandemic social distancing can significantly extend the time of the evacuation of people. This article proposes a new simple mathematical algorithm for determining the evacuation parameters under pandemic restrictions, which allows the estimation of the required minimum width of emergency exits. This is a practical tool for those responsible for ensuring safety in buildings.
RAD51 Inhibitor and Radiation Toxicity in Vestibular Schwannoma
Authors: Thielhelm Torin P. , Nourbakhsh Aida , Welford Scott M. , Mellon Eric A. , Bracho Olena , Ivan Michael E. , Telischi Fred , Fernandez‐Valle Cristina , Dinh Christine T. 
Published: March 2022

ObjectiveTo describe the RAD51 response (DNA repair) to radiation‐induced DNA damage in patient‐derived vestibular schwannoma (VS) cells and investigate the utility of RAD51 inhibitor (RI‐1) in enhancing radiation toxicity.Study DesignBasic and translational science.SettingTertiary academic facility.MethodsVS tumors (n = 10) were cultured on 96‐well plates and 16‐well slides, exposed to radiation (0, 6, 12, or 18 Gy), and treated with RI‐1 (0, 5, or 10 µM). Immunofluorescence was performed at 6 hours for γ‐H2AX (DNA damage marker), RAD51 (DNA repair protein), and p21 (cell cycle arrest protein). Viability assays were performed at 96 hours, and capillary Western blotting was utilized to determine RAD51 expression in naïve VS tumors (n = 5).ResultsVS tumors expressed RAD51. In cultured VS cells, radiation initiated dose‐dependent increases in γ‐H2AX and p21 expression. VS cells upregulated RAD51 to repair DNA damage following radiation. Addition of RI‐1 reduced RAD51 expression in a dose‐dependent manner and was associated with increased γ‐H2AX levels and decreased viability in a majority of cultured VS tumors.ConclusionVS may evade radiation injury by entering cell cycle arrest and upregulating RAD51‐dependent repair of radiation‐induced double‐stranded breaks in DNA. Although there was variability in responses among individual primary VS cells, RAD51 inhibition with RI‐1 reduced RAD51‐dependent DNA repair to enhance radiation toxicity in VS cells. Further investigations are warranted to understand the mechanisms of radiation resistance in VS and determine whether RI‐1 is an effective radiosensitizer in patients with VS.
Occupational therapists’ experiences of implementing occupation-based practice in neurology, and its impact on professional identity
Authors: Bolt Brianny , Lalor Aislinn , Barclay Linda , Brown Sarah , Growse Lauren 
Published: March 2022

Introduction Facilitating engagement in meaningful occupations underpins occupational therapy intervention. Occupation-based practice, while linked to improved professional identity and job satisfaction for occupational therapists, is challenging to implement, particularly in hospital settings. This study aimed to explore occupational therapists’ perceptions of their role, and facilitators and challenges to implementing occupation-based practice in neurology. Method This qualitative descriptive study included semi-structured interviews with seven occupational therapists working in Australian acute/sub-acute neurology settings. Findings Three themes identified: Conceptualisation versus implementation of occupation-based practice; Use of occupation-based practice impacts role satisfaction; Promoting the profession. Participants described using occupations in their practice as important, however, reported that the challenges of the neurology environment hindered their ability to carry out occupation-based practice. Conclusion This study provides insights into occupational therapist’s perceptions regarding occupation-based practice in neurology settings, finding there is a need for occupational therapists to promote their role and use of occupations in neurology settings, and that occupation-based practice impacts job satisfaction. The study highlights occupational therapists working in neurology settings would benefit from a number of approaches including student interprofessional activities, potential buddy system for new graduates and experienced clinicians, and increased support by the profession to maintain their identity as occupation-based specialists.
Investigation of the factors affecting the e-learning process in occupational therapy education during the pandemic with principal component analysis
Authors: Öztürk Başar , Akarsu Remziye , Kayıhan Hülya , Çelik Yusuf , Kayhan Saynur Elif 
Published: March 2022

Introduction The aim of this study is to examine the factors affecting the e-learning process in occupational therapy education in the COVID-19 period. Method In the study, a form containing personal information and questions about the e-learning process, the International Physical Activity Questionnaire, the Academic Self-Efficacy Scale, the Perceived Stress Scale, and the Rosenberg Self-Esteem Scale were applied to 253 occupational therapy students via the Google form. Principal component analysis was used to evaluate the data. Results A large number of questionnaires were applied in the study, and principal component analysis, an advanced statistical method that enables the interpretation of this type of big data more effectively, was used. 13 components were determined, and a variance of 88% was explained. The main components were listed as students’ self-perception about the education system, learning methods, home and university environment, information technologies, physical activity level, and academic performance/participation. Conclusion We hope that the results of our study will provide a perspective on what innovations can be made for quality improvement in occupational therapy education. It would be beneficial to increase student feedback by applying similar studies in other education programs.
Immune response against toxoplasmosis—some recent updates RH: Toxoplasma gondii immune response
Authors: Sana Madiha , Rashid Muhammad , Rashid Imran , Akbar Haroon , Gomez-Marin Jorge E , Dimier-Poisson Isabelle 
Published: March 2022

Aims Cytokines, soluble mediators of immunity, are key factors of the innate and adaptive immune system. They are secreted from and interact with various types of immune cells to manipulate host body’s immune cell physiology for a counter-attack on the foreign body. A study was designed to explore the mechanism of Toxoplasma gondii ( T. gondii) resistance from host immune response. Methods and results The published data on aspect of host (murine and human) immune response against T. gondii was taken from Google scholar and PubMed. Most relevant literature was included in this study. The basic mechanism of immune response starts from the interactions of antigens with host immune cells to trigger the production of cytokines (pro-inflammatory and anti-inflammatory) which then act by forming a cytokinome (network of cytokine). Their secretory equilibrium is essential for endowing resistance to the host against infectious diseases, particularly toxoplasmosis. A narrow balance lying between Th1, Th2, and Th17 cytokines (as demonstrated until now) is essential for the development of resistance against T. gondii as well as for the survival of host. Excessive production of pro-inflammatory cytokines leads to tissue damage resulting in the production of anti-inflammatory cytokines which enhances the proliferation of Toxoplasma. Stress and other infectious diseases (human immunodeficiency virus (HIV)) that weaken the host immunity particularly the cellular component, make the host susceptible to toxoplasmosis especially in pregnant women. Conclusion The current review findings state that in vitro harvesting of IL12 from DCs, Np and MΦ upon exposure with T. gondii might be a source for therapeutic use in toxoplasmosis. Current review also suggests that therapeutic interventions leading to up-regulation/supplementation of SOCS-3, IL12, and IFNγ to the infected host could be a solution to sterile immunity against T. gondii infection. This would be of interest particularly in patients passing through immunosuppression owing to any reason like the ones receiving anti-cancer therapy, the ones undergoing immunosuppressive therapy for graft/transplantation, the ones suffering from immunodeficiency virus (HIV) or having AIDS. Another imortant suggestion is to launch the efforts for a vaccine based on GRA6Nt or other similar antigens of T. gondii as a probable tool to destroy tissue cysts.
Clinical and histopathological features of conjunctival “Teddy bear” granuloma: A case series
Authors: Lozano-Bustillo Alejandra , Ríos y Valles-Valles Dolores , Hernández-Ayuso Ivette , Rodríguez-Reyes Abelardo A. 
Published: March 2022

Purpose To describe the clinical features, histopathological findings, and prognosis of conjunctival Teddy bear granuloma (TBG) diagnosed in a Mexican ophthalmologic referral center in a period of 64 years. Methods We reviewed clinical and histopathological material from all patients with documented conjunctival TBG. Patient′s age, gender, location, clinical signs and symptoms, duration, treatment and, specimen size, were evaluated. Formalin-fixed paraffin embedded 5 microns hematoxylin-eosin stained slides and periodic acid-Schiff special stain as well as examination under polarized light microscopy were performed in all cases. Results A total of 5 conjunctival TBG were collected. The ages of the patients ranged between 2 and 11 with a mean of 6 years. Female to male ratio was 4:1. The right inferior fornix was involved in 4 cases (80%) with clinical diagnosis of conjunctival mass of unknown etiology. Treatment consisted of surgical removal by slit-lamp biomicroscopy (3 cases) and in the operating room (2 cases). No complications were informed in a short follow-up period. Histopathologically, numerous cross-sections of synthetic and non-synthetic fibers surrounded by multinucleated foreign body giant cells, epithelioid histiocytes, lymphocytes, plasma cells and sparse neutrophils were seen. Polarization light microscopy demonstrated numerous birefringent colorful foreign fibers. The follow-up period of the patients ranged between 1 and 32 weeks with a mean of 10 weeks. Conclusions Most patients with TBG are children with vague, non-specific symptoms troubling precise clinical diagnosis. Treatment of choice involves surgical excision of the foreign body granuloma followed by topical corticosteroids. All surgical specimens obtained must be sent for histopathological examination. Special awareness is recommended during COVID-19 pandemic lockdown to prevent potential exposure to fibers that may cause conjunctival TBG.