bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tinjauan Yuridis Terhadap Kesalahan Profesi Oleh Tenaga Kesehatan
Authors: Nofil Gusfira  
Published: December 2022

Untuk memenuhi kebutuhan manusia memerlukan bantuan orang lain, karena manusia tidak dapat memenuhi kebutuhannya pribadinya kecuali atas bantuan orang lain. Begitu juga hal ketika sakit masyarakat tentu membutuhkan tenaga kesehatan untuk melakukan pelayanan medis sebagai upaya penyembuhan. Sebagai upaya penyembuhan salah satunya adalah dengan cara mengunjungi Rumah sakit atau tenaga medis yang berprofesi sebagai tenaga kesehatan. Rumah sakit dan tenaga kesehatan dalam melakukan pelayanan medis tentu sudah memiliki standar pelayanan yang diatur dalam Undang-undang. Namun adakalanya terjadi kesalahan apakah dilakukan karena ketidaksengajaan atau dengan unsur kesengajaan. Tujuan Penelitian ini adalah untuk memberikan analisa hukum bahwa apabila terjadi kesalahan yang dilakukan oleh tenaga kesehatan maka ketentuan yang termuat dalam Peraturan tentang Perlindungan Konsumen Nomor 8 Tahun 1999 juga berlaku sebagai dasar hukum untuk memberikan perlindungan terhadap konsumen. Metode dalam penelitian ini adalah penelitian hukum normatif. Dari analisa yang ada maka pasien dapat dikategorikan kepada konsumen sehingga semua ketentuan yang terdapat dalam Undang-undang Perlindungan konsumen juga berlaku terhdapa pasien yang mengalami kerugian. Pasien dapat meminta pertanggungjawaban tenaga kesehatan dengan melakukan permintaan pertanggungjawaban melalui jalur hukum secara perdata atau pidana dan melalui jalur perjanjian, diluar jalur hukum.
PENGARUH GREEN INNOVATION TERHADAP FIRM VALUE DENGAN ENVIRONMENTAL MANAGEMENT ACCOUNTING SEBAGAI VARIABEL INTERVENING
Authors: Roza Mulyadi  , Maulana Rizki 
Published: December 2022

Penelitian ini dilakukan untuk mengetahui pengaruh inovasi hijau (GI) terhadap nilai perusahaan (FV) dengan akuntansi manajemen lingkungan (EMA) sebagai variabel intervening. Populasi yang digunakan dalam penelitian ini adalah perusahaan manufaktur dan sektor utama yang terdaftar di Bursa Efek Indonesia periode 2014-2019. Dengan menggunakan metode purposive sampling, didapatkan 30 perusahaan yan memenuhi kriteria sebagai sampel penelitian. Penelitian ini menggunakan data sekunder yan diperoleh dari website Bursa Efek Indonesia. Metode analisis yang digunakan pada penelitian ini adalah regresi linier berganda dengan mengunakan aplikasi penolah data IBM SPSS 22. Hasil penelitian ini menunjukkan bahwa: (1) green innovation berpengaruh positif terhadap environmental management accounting. Hal ini ditunjukkan dengan besarnya tingkat signifikansi 0,000 yang berada dibawah tingkat signifikansi 0,05 (0,000< 0,05). (2) green innovation tidak berpengaruh positif terhadap firm value. Hal ini ditunjukkan dengan besarnya tingkat signifikansi 0,711 yang berada diatas tingkat signifikansi 0,05 (0,711> 0,05). (3) environmental management accounting berpengaruh positif terhadap firm value. Hal ini ditunjukkan dengan besarnya tingkat signifikansi (ρ-value) 0,000 yang berada dibawah tingkat signifikansi 0,05 (0,000< 0,05). (4) environmental management accounting dapat memediasi pengaruh green innovation pada firm value. Hal ini ditunjukkan dengan besarnya tingkat signifikansi (ρ-value) 0,000 yang berada dibawah tingkat signifikansi 0,05 (0,000< 0,05).

Kata Kunci: Akuntansi Manajemen Lingkungan, Inovasi hijau, Nilai perusahaan
Investigating Banking Profitability: Evidence from Commercial Banks in Emerging Country
Authors: Irhamni Firly 
Published: December 2022

We empirically analyse the determinants of commercial banking profitability in Indonesia for the period 2014-2018. We contribute to the growing literature in practical ways, first we propose suggestion to the business of the commercial banking sector in Indonesia, especially in decision-making of financial condition, in order to maximize the performance of the company and shareholders, so that the banking company's shares can continue to survive and have large returns. Also, it is expected to provide insight and knowledge about the extent to which the relationship between the banking sound’s level variable and its Profitability. The sample in this study amounted to 17 banking companies. This study uses purposive sampling method and we apply multiple linear regression approach with SPSS. We found that credit portfolio quality has a negative and significant effect on profitability, bank solvency has a positive and significant effect on profitability, interest level has a positive and insignificant effect on profitability. Efficiency ratio has a negative and insignificant effect on profitability, and liquidity has a positive and insignificant effect on profitability.

Keywords: bank profitability, emerging economy, credit quality, solvency, interest margin, efficiency
Higher serum apolipoprotein B level will reduce the bone mineral density and increase the risk of osteopenia or osteoporosis in adults
Authors: Zhu RunJiu , Xu Yuan , Wang ZhaoFu , Li Hui , Song MingRui , Wan HaoYang , Yang Hong , Zhang Xin , Chai Yu , Yu Bin 
Published: December 2022

Objective: There is very limited evidence in the NHANES database linking serum apolipoprotein B and lumbar bone mineral density (BMD) in adults aged 20–59 years. There are few studies associating apolipoprotein B concentrations with BMD, and there is some debate about the association between obesity and BMD. Therefore, the purpose of this study was to determine the association between serum apolipoprotein B concentrations and lumbar spine BMD in adults aged 20–59 years and to predict its association with risk of osteopenia or osteoporosis.Methods: A cross-sectional study of the entire US ambulatory population was conducted using data from the National Health and Nutrition Examination Survey (NHANES) database. Weighted multiple regression equation models were used to assess the association between serum apolipoprotein B and lumbar BMD. A logistic weighted regression model was used to assess the association between serum apolipoprotein B concentrations and risk of osteopenia or osteoporosis. Subsequent stratified analyses were performed to refine the primary population of association.Results: Our study showed a significant negative association between serum apolipoprotein B concentration and lumbar BMD and a significant positive association with the risk of osteoporosis or osteopenia in the total population. After stratifying by sex, age and race, we concluded differently. The association of serum apolipoprotein B concentration with lumbar spine BMD and risk of osteopenia or osteoporosis was significant in male, but not in female. After stratification by age, the negative association between serum apolipoprotein B concentrations and lumbar BMD and the positive association with risk of osteopenia or osteoporosis was more significant in the 30–39 and 50–59 years age groups. When stratified by race, serum apolipoprotein B concentrations were significantly negatively associated with lumbar BMD and positively associated with risk of osteopenia or osteoporosis in Mexican American and non-Hispanic black populations. Thus, these findings suggest that these associations are influenced by sex, age, and race, respectively.Conclusion: Our results suggest that the association between serum apolipoprotein B levels and the risk of lumbar BMD and osteopenia or osteoporosis varies by sex, age, and race. In men, elevated serum apolipoprotein B levels were negative for bone quality. Elevated serum apolipoprotein B levels in the age groups 30–39 and 50–59 years also had a negative effect on bone quality. In the Mexican American and Non-Hispanic Black populations, elevated serum apolipoprotein B levels also had a significant negative effect on bone quality.
Mean versus variability of lipid measurements over 6 years and incident cardiovascular events: More than a decade follow-up
Authors: Masrouri Soroush , Cheraghi Leila , Deravi Niloofar , Cheraghloo Neda , Tohidi Maryam , Azizi Fereidoun , Hadaegh Farzad 
Published: December 2022

BackgroundLipid variability (LV) has emerged as a contributor to the incidence of cardiovascular diseases (CVD), even after considering the effect of mean lipid levels. However, these associations have not been examined among people in the Middle East and North Africa (MENA) region. We aimed to investigate the association of 6-year mean lipid levels versus lipid variability with the risk of CVD among an Iranian population.MethodsA total of 3,700 Iranian adults aged ≥ 30 years, with 3 lipid profile measurements, were followed up for incident CVD until March 2018. Lipid variability was measured as standard deviation (SD), coefficient of variation (CV), average real variability (ARV), and variability independent of mean (VIM). The effects of mean lipid levels and LV on CVD risk were assessed using multivariate Cox proportional hazard models.ResultsDuring a median 14.5-year follow-up, 349 cases of CVD were recorded. Each 1-SD increase in the mean levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), TC/high-density lipoprotein cholesterol (HDL-C), and non-HDL-C increased the risk of CVD by about 26–29%; for HDL-C, the risk was significantly lower by 12% (all p-values &lt; 0.05); these associations resisted after adjustment for their different LV indices. Considering LV, each 1-SD increment in SD and ARV variability indices for TC and TC/HDL-C increased the risk of CVD by about 10%; however, these associations reached null after further adjustment for their mean values. The effect of TC/HDL-C variability (measured as SD) and mean lipid levels, except for LDL-C, on CVD risk was generally more pronounced in the non-elderly population.ConclusionSix-year mean lipid levels were associated with an increased future risk of incident CVD, whereas LV were not. Our findings highlight the importance of achieving normal lipid levels over time, but not necessarily consistent, for averting adverse clinical outcomes.
Measuring the impact of student success retention initiatives for engineering students at a private research university
Authors: Wick David P. , Atindama Emmanuel , Athavale Prashant , Mondal Sumona , Ramsdell Michael W. , Jaspersohn Robert P. , Moosbrugger John C. 
Published: December 2022

IntroductionStudent success in Science, Technology, Engineering, and Mathematics (STEM) is a national concern. To increase engineering retention and graduation rates at a small private institution, a university council developed a binary classifier to identify high-risk students and proposed interventions that included decoupling first-year Physics and Calculus courses, support in introductory Calculus, and Spatial Visualization (SV) training. This paper aims to validate the binary classifier used to identify the under-prepared students entering their first year and assess the impact of the interventions. We provide a comparative analysis of student success metrics for high-risk engineering students across a decade of cohorts, including 5 years before (2006–2010) and 5 years after (2011–2015) implementation of intentional strategies.MethodsWe validated the binary classifier using an accuracy measure and Matthews Correlation Coefficient (MCC). We used the 2-population proportion test to compare STEM retention and 4- and 6-year graduation rates of High-Risk engineering students before and after interventions and compare student performance in early foundation STEM courses across the same time frame.ResultsThe binary classification model identified High-Risk students with an accuracy of 63–70% and an MCC of +0.28 to +0.30. In addition, we found statistically significant improvement (p &lt; 0.001) in the STEM retention rates, 6-year graduation rates, and first part of Physics, Calculus, and Chemistry sequences after the interventions.DiscussionThe methodology and strategies presented may provide effective guidance for institutions seeking to improve the overall performance of undergraduate students who otherwise might struggle in their first-year engineering curriculum.
The number of metastatic lymph nodes optimizes staging in patients aged 55 years or older with papillary thyroid cancer
Authors: Sun Yun-Gang , Chen Fei , Sun Qiao-Ling , Tian Jin-Yu , He Xiao-Chuan 
Published: December 2022

PurposeCurrent staging criteria for papillary thyroid cancer (PTC) do not include the number of metastatic lymph nodes (LNs), which is highly predictive of survival in multiple cancers. The LN metastasis burden is particularly relevant for older adults with thyroid cancer because of their poor prognosis. We examined a modified staging system for this population utilizing node number (Nn).MethodsOverall, 14,341 patients aged 55 years or older with stage I-IVB PTC were identified in the 2004–2015 Surveillance, Epidemiology and End Results database. Cox regression models were conducted to test the relationship between positive LN number and PTC-specific survival (PTCSS). Independent training/validation sets were used to derive and validate a new revised TNnM grouping. The 8th edition American Joint Committee on Cancer TNM staging system was compared with TNnM stage by calculating the 10-year PTCSS rates, Harrell’s concordance index (C-index), and Akaike’s information criterion (AIC).ResultsAn increase in number of LN metastases was identified as an independent, negative prognostic factor for PTCSS in multivariate analysis. 10-year PTCSS for stage I-IVB based on the AJCC 8th edition TNM were 98.83%, 93.49%, 71.21%, 72.95%, and 58.52%, respectively, while 10-year PTCSS for the corresponding stage in the TNnM were 98.59%, 92.2%, 83.26%, 75.24%, and 56.73%, respectively. The revised TNnM stage was superior, with a higher C-index and a lower AIC in both the training and validation cohorts.ConclusionThe TNnM staging system for PTC patients ≥ 55 years could be associated with improved outcomes. External validation studies of this system are warranted.
Measuring educational neglect using the Q method: A model based on the burden of disseminated tungiasis
Authors: Martins Ana Carolina Tardin , Martins Luciana Pereira Freire , Timbó Renata Velozo , Bezerra Natanael Victor Furtunato , Urdapilleta Ada Amalia Ayala , Filho Florival Martins Passos , Gomes Ciro Martins 
Published: December 2022

BackgroundA paramount factor in the control of neglected tropical diseases from both medical and social aspects is education. New strategies must be constantly pursued to test and provide educational information related to diseases affecting vulnerable populations. We applied the Q method as a model to measure educational neglect based on the burden of disseminated tungiasis.MethodsUsing a saturation method for sample size calculation, we recruited students and healthcare professionals to evaluate and classify 27 statements related to the prevention, control and treatment of tungiasis. After quantitative analysis, the Q method was applied based on the paired use of the centroid method and Varimax rotation, and 4 factors were extracted representing the main sets of viewpoints among the participants.ResultsWe included 119 healthcare professionals with different academic degrees. Statements classified by specialists with a + agreement were also classified as a + agreement by most of the participants. However, we detected 5 important disagreements related to the topical treatment of tungiasis and control of the disease in the environment and animals. The Q method showed that almost no consensus was detected for four statements. The classification of each statement was not related to the participants' academic degree.ConclusionsThere is significant educational neglect related to tungiasis prevention and treatment in healthcare sciences in Brazil. We conclude that the Q method may be an interesting strategy alone or associated with quantitative strategies for detecting educational limitations related to neglected diseases. In countries where neglected diseases are endemic, a detailed study evaluating the quality of education related to these diseases must be prioritized.
Prognostic significance and immune landscape of a fatty acid metabolism-related gene signature in colon adenocarcinoma
Authors: Liu Xia , Fang Xisheng , Lu Lin , Liu Guolong 
Published: December 2022

Background: Fatty acid metabolism (FAM), as a hallmark of caner, plays important roles in tumor initiation and carcinogenesis. However, the significance of fatty acid metabolism-related genes in colon adenocarcinoma (COAD) are largely unknown.Methods: RNA sequencing data and clinical information were downloaded from the Cancer Genome Atlas (TCGA) cohort. Univariate and multivariate Cox regression analyses were utilized to construct a fatty acid metabolism-related gene signature. Kaplan-Meier survival and receiver operating characteristic (ROC) analyses were used to verify the performance of this signature. GEO datasets were applied to validate the signature. Maftools package was utilized to analyze the mutation profiles of this signature. Correlation between the risk signature and stemness scores was compared by RNA stemness score (RNAss). Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene set variation analysis (GSVA) were performed to explore the potential functions and signaling pathways. Immune landscape of the signature was explored by analyzing different immune cells infiltration, immune functions and microsatellite instability. A nomogram was constructed by combining the risk signature and multiple clinical factors. Expression levels and prognostic values of the risk genes were revealed in the cancer genome atlas and GEO databases. Moreover, the expression the risk genes were measured in cell lines using real time quantitative PCR (qRT-PCR).Results: Eight fatty acid metabolism-related genes (CD36, ENO3, MORC2, PTGR1, SUCLG2, ELOVL3, ELOVL6 and CPT2) were used to construct a risk signature. This signature demonstrated better prognostic value than other clinicopathological parameters, with AUC value was 0.734 according to the cancer genome atlas database. There was negative correlation between the riskscore and RNA stemness score. The patients in the high-risk group demonstrated higher infiltration of M0 macrophages, and less infiltration of activated CD4 memory T cells and Eosinophils. There were more MSI patients in the high-risk group than those in the low-risk group (38% vs. 30%). The risk scores of patients in the MSI group were slightly higher than those in the microsatellite stability group. Gene ontology, kyoto encyclopedia of genes and genomes and gene set variation analysis enrichment analyses showed that several metabolism-related functions and signaling pathways were enriched. A nomogram showed good predictive capability of the signature. Moreover, qRT-PCR revealed upregulated expression of ENO3, MORC2, SUCLG2 and ELOVL6, and downregulated expression of CPT2 in all examined colon adenocarcinoma cell lines.Conclusion: This study provided novel insights into a fatty acid metabolism-related signature in the prognosis an immune landscape of colon adenocarcinoma patients.
Molecular characterization of immunogenic cell death indicates prognosis and tumor microenvironment infiltration in osteosarcoma
Authors: Liu Zhongyue , Liu Binfeng , Feng Chengyao , Li Chenbei , Wang Hua , Zhang Haixia , Liu Ping , Li Zhihong , He Shasha , Tu Chao 
Published: December 2022

IntroductionOsteosarcoma (OS) is a highly aggressive bone malignancy with a poor prognosis, mainly in children and adolescents. Immunogenic cell death (ICD) is classified as a type of programmed cell death associated with the tumor immune microenvironment, prognosis, and immunotherapy. However, the feature of the ICD molecular subtype and the related tumor microenvironment (TME) and immune cell infiltration has not been carefully investigated in OS.MethodsThe ICD-related genes were extracted from previous studies, and the RNA expression profiles and corresponding data of OS were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus database. The ICD-related molecular subtypes were classed by the "ConsensusclusterPlus" package and the construction of ICD-related signatures through univariate regression analysis. ROC curves, independent analysis, and internal validation were used to evaluate signature performance. Moreover, a series of bioinformatic analyses were used for Immunotherapy efficacy, tumor immune microenvironments, and chemotherapeutic drug sensitivity between the high- and low-risk groups.ResultsHerein, we identified two ICD-related subtypes and found significant heterogeneity in clinical prognosis, TME, and immune response signaling among distinct ICD subtypes. Subsequently, a novel ICD-related prognostic signature was developed to determine its predictive performance in OS. Also, a highly accurate nomogram was then constructed to improve the clinical applicability of the novel ICD-related signature. Furthermore, we observed significant correlations between ICD risk score and TME, immunotherapy response, and chemotherapeutic drug sensitivity. Notably, the in vitro experiments further verified that high GALNT14 expression is closely associated with poor prognosis and malignant progress of OS.DiscussionHence, we identified and validated that the novel ICD-related signature could serve as a promising biomarker for the OS's prognosis, chemotherapy, and immunotherapy response prediction, providing guidance for personalized and accurate immunotherapy strategies for OS.
Interactive neurotoxicity of environmentally relevant concentrations of polystyrene nanoplastics and butyl methoxydibenzoyl methane on early zebrafish embryos
Authors: Zhou Ranran , Yang Haohan , Zhou Dao , Yang Shixin , Shi Zhiqiao , Jin Qijie , Ding Zhuhong 
Published: December 2022

Organic ultraviolet filters (OUVFs) and nanoplastics (NPs) are two important new pollutants that coexist widely in freshwater and coastal habitats. Both OUVFs and MPs can be taken up by aquatic organisms and may be toxic or co-toxic. In this study, the neurotoxicity and interaction neurotoxicity of the typical OUVFs butyl methoxydibenzoyl methane (BM-DBM) and polystyrene nanoplastics (PS-NPs) on zebrafish at environmental concentrations were comprehensively investigated at the tissue and molecular levels using transgenic or non-transgenic zebrafish. Results showed that both BM-DBM and PS-NPs induced abnormal expression of developmental genes neurogenin 1, glial fibrillary acidic protein, Finkel-Biskis-Jinkins osteosarcoma oncogene, growth-associated protein 43, synapsin IIa, and apoptosis regulator a (Bcl2a), Bcl2 associated x and apoptosis-related cysteine peptidase a, neuronal loss, motor neuron axon deletion, neuronal apoptosis and behavioral abnormalities in larvae thus being neurotoxic. BM-DBM also specifically interferes with neurotransmitter systems and affects signaling between neurons. In addition, PS-NPs and BM-BDM exerted synergistic and antagonistic effects in inducing apoptosis in neuronal cells and developmental neurotoxicity, respectively. Our results highlight the neurotoxic risk of PS-NPs and BM-BDM and the complex interactive neurotoxic effects of the two. We anticipate that our study may lay the foundation for ecological risk assessment of OUVFs and PS-NPs and exploration of complex interactions between PS-NPs and hydrophobic organic pollutants.