bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decrease Rate of Platelet Count as a Marker for Complications of Preeclampsia: A Cross-Sectional Study
Authors: Mayama Michinori , Morikawa Mamoru , Yamada Takashi , Umazume Takeshi , Noshiro Kiwamu , Nakagawa Kinuko , Saito Yoshihiro , Chiba Kentaro , Watari Hidemichi 
Published: February 2022

Abstract
BackgroundThrombocytopenia is considered a sign of maternal organ damage of preeclampsia. However, platelet count distribution during pregnancy shifts downward even in uncomplicated women, and platelet counts in some uncomplicated women falls below the cutoff value of thrombocytopenia. Thus, not only absolute platelet counts number but also platelet count reduction rate may relate with adverse outcomes of preeclampsia. This study aimed to evaluate whether the overall platelet count reduction rate was associated with adverse outcomes of preeclampsia. MethodsThis retrospective study included 240 singleton pregnant women with preeclampsia. Overall platelet count reduction ≥30.0% was used as a cut-off value because 10–20% platelet counts reduction can be observed in uncomplicated pregnancy. The association between the overall platelet count reduction from the first trimester ≥30.0% and adverse outcomes; severe hypertension, uteroplacental dysfunction, maternal organ damage except for thrombocytopenia, and preterm delivery <34 gestational weeks were analyzed. Moreover, subgroup analysis was conducted in women without thrombocytopenia.ResultsA total of 95/240 (39.6%) of women had ≥30.0% of overall platelet count reduction from the first trimester. The incidences of maternal organ damage except for thrombocytopenia (12.4%, 22.1%; p = 0.047), and preterm delivery <34 gestational weeks (30.3%, 48.4%; p = 0.005) were higher in women with ≥30.0% of overall platelet count reduction than those otherwise. Even in women without thrombocytopenia (platelet counts ≥150 × 109/L), severe hypertension (66.2%, 85.4%; p = 0.018), and preterm delivery <34 gestational weeks (30.8%, 51.2%; p = 0.017) were more frequently observed in women with ≥30.0% of overall platelet count reduction than those otherwise.ConclusionsA ≥30.0% of overall platelet count reduction from the first trimester was associated with adverse outcomes of preeclampsia even in women without thrombocytopenia.
Cost of research and education activities in US colleges - scalability, complementarity, and heterogeneous efficiency
Authors: Shimao Hajime , Li Xiaoxiao , Price Michael , Kempes Chris 
Published: February 2022

Abstract
Universities in the United States are remarkably diverse in their efficiency, both in terms of research output and educational achievement. Recent work has highlighted how important this heterogeneity is by showing that different broad categories of institutions demonstrate different scaling relationships for various features as a function of the number of students. These differences in scaling relationships reflect differences in organizational goals, constraints, and strategies. In the existing literature, this heterogeneity is under-explored and often ignored due to the lack of appropriate data and methodological limitations. In this paper, we address this problem by exploiting a newly consolidated dataset and adopting a neural-network based method to infer cost functions for universities. Our analyses reveal (1) the specific economy of scale in two distinct output types (education and research), (2) the nature of the trade-off between research and education efficiency, and (3) significant efficiency differences across universities. Particularly, we show that while both research and education outputs generally exhibit an economy of scale, their scalability largely depends on their size and other institutional characteristics. Similarly, research and education activities are complementary to each other (economy of scope) only in some situations, particularly when the scale of production is small to medium. Consequently, the cost isoclines of universities are highly non-convex, implying the possibility of multiple optima that may explain the diverse strategies universities adopt, and potential efficiency gains from specialization. It also suggests that some basic assumptions of microeconomic models may not be empirically supported.
Comparison on FTIR Spectrum and Thermal Analysis for Four Types of Rehamnnia Glutinosa and Their Extracts
Authors: Zhang Maosen , Ding Rong , Hu Fang 
Published: February 2022

Abstract
Rehmannia glutinosa (R. glutinosa) is a plant material and widely used clinically in China. Due to different processing methods and various healing effects, there are four types of R. glutinosas (RR, RRP, RRC, and RRPC) and their corresponding extracts for convenient use. As complicated mixture systems, chemical components of R. glutinosa are very difficult to identify and discriminate. In order to effectively control its quality during processing, Fourier transform infrared spectroscopy (FTIR), second derivative spectrum, and thermal analysis were used in this study. It was found that the major active ingredients were retained in the extracts when extracted from their corresponded R. glutinosa and subtle differences could be distinguished by the second derivative spectrum. FTIR spectrum, second derivative spectrum, and thermal analysis are valid method to validate and identify plant material, traditional Chinese medicine material, as well as their corresponding extracts.
Rad54L promotes bladder cancer progression by regulating cell cycle and cell senescence
Authors: Chen Minfeng , Wang Yinzhao , Zhou Tailai , Weng Liang , Chen Hengxing , Wen Sijie , Dao Pinghong 
Published: February 2022

Abstract
Bladder cancer is the most prevalent cancer of the urinary system, but its pathogenesis is still poorly understood. Several reports have suggested that gene damage repair is highly correlated with tumor development and drug resistance, in which homologous recombination repair gene Rad54L, seems to play an important role, through yet unclear mechanisms. Therefore, this study stratified cancer patients by Rad54L expression in bladder cancer tissue, and high Rad54L expression was associated with a poor prognosis. Mechanistically, we demonstrate that high Rad54L expression promotes abnormal bladder tumor cell proliferation by changing the cell cycle and cell senescence. In addition, this study also suggests that Rad54L may be associated with p53, p21, and pRB in bladder cancer tissue. In summary, this study exposes Rad54L as potential a prognostic biomarker and precision treatment target in bladder cancer.
From plant genetics to environment of selection: exploring the drivers of fungal communities in the roots and rhizosphere of Brassica napus
Authors: Bazghaleh Navid , Li Yunliang , Vail Sally , Mamet Steven D , Siciliano Steven D. , Helgason Bobbi 
Published: February 2022

Abstract
PurposeOur aim was to characterize the fungal root and rhizosphere microbiomes of genetically diverse Brassica napus lines in a temporally-intensive, multi-site field study to assess the relative contributions of plant genetics, growth stage and environmental conditions to microbiome composition and to identify fungi that were associated with yield performance. MethodsSixteen B. napus lines were grown across three sites in the Canadian Prairies. Sixteen lines were sampled weekly for ten weeks at one site in 2016, as well as a subset of eight lines at the same site in 2017; the sixteen lines were sampled three times at three sites in 2017. The root and rhizosphere fungal microbiomes were assessed using amplicon sequencing of the fungal ITS region with the Illumina MiSeq. ResultsOverall, B. napus line was associated with only 2% of the variation in community structure. Constrained to within a single site-year, this association increased to between 4 and 16% and to between 25 and 37% in a single week within individual sites. The fungal core microbiome consisted of 38 ASVs; Olpidium, Fusicola, Fusarium, Gibberella, Mortierella, and Cutaneotrichosporon were the most abundant taxa with varied abundance during different B. napus growth stages. Thirteen ASVs across three growth stages were highly associated with B. napus yield. ConclusionOur results point to the potential to exploit the B. napus microbiome for improving plant performance by targeting the core taxa identified here as well as those that lead to greater fitness under more specific conditions.
Evaluation Of School Mental Health Promotion Program: A Qualitative Study
Authors: Borji Mitra , Naserbakht Morteza , Hajebi Ahmad , Fazeli Asal , Khorrami Zahra , Ranjbar Helia , Hajebi Amirali 
Published: February 2022

Abstract
Background: Due to the need to identify problems related to mental health among students and their proper management by offering specialized medical services to them, recently a relevant research project has been fully implemented in schools of all grades in Iran. Since the only way to measure the effectiveness and find the strengths and weakness of a program is to evaluate it, the present study aims to monitor and evaluate the mentioned project in order to improve the quality of project implementation, identify defects and shortcomings and upgrade the existing system. Methods: The present study was a qualitative study using conventional content analysis that used a semi-structured in-depth interview to obtain information from group of stakeholders. Selected instructors, teachers, principals and designers of the School Mental Health Promotion Program were the target of the study. Results: The findings of the present study were presented in four categories of program strengths, program weaknesses, factors preventing achievement of program objectives and recommendations for program improvement. It is to be noted that 14 subcategories were also devised, and finally, 50 codes were extracted. The overall results of the evaluation of the School Mental Health Program showed its effectiveness. Conclusions: The new and practical model of School Mental Health Program has opened a new perspective to school-based interventions. However, the expectation of full implementation and continuation of this program in the short term and with limited resources does not seem very realistic because making change is often challenging and fraught with problems and obstacles.
Prediction and Diagnosis of Respiratory Disease by Combining Convolutional Neural Network and Bi-directional Long Short-Term Memory Methods
Authors: Li Li , Ayiguli Alimu , Luan Qiyun , Yang Boyi , Gong Hui , Zulipikaer Abudureherman , Xu Jingran , Zhong Xuemei , Subinuer Yilamujiang , Ren Jiangtao , Zou Xiaoguang 
Published: February 2022

Abstract
Objective Based on the respiratory disease big data platform in southern Xinjiang, we established a model that predicted and diagnosed chronic obstructive pulmonary disease, bronchiectasis, pulmonary embolism and pulmonary tuberculosis, and provided assistance for primary physicians. Methods The method combined convolutional neural network (CNN) and long-short-term memory network (LSTM) for prediction and diagnosis of respiratory diseases. We collected the medical records of inpatients in the respiratory department, including: chief complaint, history of present illness, and chest computed tomography. Preprocessing of clinical records with“ jieba” word segmentation module, and the Bidirectional Encoder Representation from Transformers (BERT) model was used to perform word vectorization on the text. The partial and total information of the fused feature set was encoded by convolutional layers, while LSTM layers decoded the encoded information. Results The precisions of traditional machine-learning, deep-learning methods and our proposed method were 0.6, 0.81, 0.89, and F1 scores were 0.6, 0.81, 0.88, respectively. Conclusion Compared with traditional machine learning and deep-learning methods that our proposed method had a significantly higher performance, and provided precise identification of respiratory disease.
Impact Of A Specifically Designed Antenatal Class For First-Time Fathers On Their Experience Of Childbirth
Authors: Cornet Isabelle , de Tejada Begoña Martinez , Guittier Marie-Julia 
Published: February 2022

Abstract
Purpose: Most fathers describe the experience of witnessing childbirth as very positive, but some feel unsupported and excluded. Offering specific antenatal classes for fathers could improve their experience. This study compares the childbirth experience of first-time fathers who attended specific antenatal classes for men (intervention group) with those who did not (non-intervention group).Methods: We performed a comparative study at a tertiary maternity hospital in Switzerland using First-Time Father Questionnaire (FTFQ) one month after childbirth. We assessed the satisfaction of the specific antenatal classes with a questionnaire with open and closed questions.Results: A total of 121 fathers for the non-intervention group and 52 for the intervention group completed the FTFQ. The score of two of the three dimensions of the FTFQ were significantly better: the professional support was reduced from 1.98 (SD = 0.52) in the non-intervention group to 1.69 (SD = 0.55) in the intervention group, p = 0.001; and the prenatal preparation from 1.70 (SD = 0.57) to 1.48 (SD = 0.51) respectively, p = 0.019. In the intervention group, 75% of fathers-to-be felt better prepared for the childbirth and 95% enjoyed the classes being for men only. The qualitative analysis of open questions showed positive experiences.Conclusions: Attending specific antenatal classes for first-time fathers improves the experience of childbirth. Their experience reported in terms of sharing and solidarity seems to be meaningful. Offering fathers-to-be a specifically dedicated space for expression is a way to support their transition to fatherhood.
Identification of a Six-lncRNA Prognosis Model for Predicting Progression-Free Survival in Patients with Thyroid Cancer
Authors: Ji Pei , Xu Tingyu , Hu Yifang , Cui Dai , Wang Zhongmin 
Published: February 2022

Abstract
Background: Thyroid cancer is the most common malignant tumor of the endocrine system. Long non-coding RNAs (lncRNAs) have been demonstrated as novel biomarkers for cancer prognosis. Methods: In this study, we performed differential expression analysis of lncRNA expression profiles in GEO datasets. LASSO regression analysis was conducted to identify lncRNA-based prognosis model that can predict progression-free survival in thyroid cancer patients from The Cancer Genome Atlas (TCGA). Further functional analysis revealed the potential biological functions of the lncRNAs.Results: A risk score model based on six lncRNA biomarkers were established after LASSO Cox regression analysis. The prognostic value of the 6-lncRNA prognosis model was successfully validated and ROC curves was analysed. Patients were classified into high- and low-risk groups using the 6-lncRNA signature-based risk score. Patients in the low-risk group had significantly better progression-free survival than high-risk group. The result of multivariate analysis showed that the six-lncRNA signature was independent from clinical features such as age, gender and stage. GO and KEGG enrichment analysis and estimation of immune infiltration suggested that the lncRNAs might closely associated with tumorigenesis. Conclusion: Our study has constructed a novel six-lncRNA prognosis model to improve progression-free survival prediction in patients with thyroid cancer.
“My Life Became More Meaningful”: Confronting One’s Own End Of Life And Its Effects On Well-Being - A Qualitative Study
Authors: Kukla Helena , Herrler Angélique , Strupp Julia , Voltz Raymond 
Published: February 2022

Abstract
Background: The perception of being closer to death can be experienced due to old age or life-limiting diseases, and can pose profound existential challenges. Actively confronting death-related issues and existential questions may increase psychosocial comfort and stimulate personal growth, whereas dysfunctional coping may lead to existential distress. To date, research on individual and (semi-)professional approaches to confronting the own end of life and the effects on one’s well-being remain scarce. Therefore, the aim of this study was to explore individual strategies and wishes in order to derive ideas for appropriate support concepts.Methods: Twenty semi-structured interviews were conducted with people over the age of 80 (n = 11) and with a life-limiting disease (n = 10). The interviews were transcribed verbatim and independently coded by two researchers according to Braun and Clarke's thematic analysis approach.Results: While the use of (semi-)professional approaches (e.g. therapeutic support) to confronting existential questions in the shape of one's impending death was rare, individual coping strategies did have a positive impact on psychosocial comfort. There were hardly any significant differences between the participants aged 80 and over and those with a life-limiting disease in terms of individual coping strategies or how they approached the ends of their lives. Both groups reported that theoretical education, preparing for the ends of their lives (e.g. funerals), talking about death-related topics, reflecting on death-related topics, and contemplating death in a spiritual sense had positive effects on their assurance, self-determination and relief. The necessity of confrontation and a desire for low-threshold, accessible and flexible services to meet their existential and spiritual needs were highlighted.Conclusions: There is both a desire and a need for the addressing of existential questions. Outside of private contexts, however, the participants possessed little awareness of support services that focused on confronting end-of-life issues, and rarely used such services. Efforts to raise awareness for psychosocial and spiritual needs should be implemented within the care system, together with low-threshold support concepts, in order to increase psychosocial well-being. More research evaluating individual approaches to confronting the own end of life are needed to better understand this determinant of well-being and its mechanisms of action.Trial registration: www.germanctr.de, DRKS-ID: DRKS00020577
Vulnerability Status-Quo of the Underprivileged Communities in Mongla from Climate Change perspective
Authors: Munna Masudul Haque , Alam Md. Sajadul , Fatema Kaniz , Jimmy Abdun Naqib 
Published: February 2022

Abstract
Climate-induced changes, such as extreme cyclones, devastating tidal surges, severe floods, river erosion, excessive rainfall, and overwhelming salinity intrusion, occur more frequently and unpredictably across Bangladesh. The frequency and intensity of these hazards are likely to increase due to climate change. This study considers the baseline situation of the grassroots people of Mongla Upazila & community perception of climate change vulnerability and the local community-based adaptation strategies. Data were collected from respondents in Sundarban, Mithakahali, Chandpai, Sonailtola unions of Mongla Upazila, Bagerhat District, Bangladesh, an area subjected to frequent climate-related hazards. Many of the respondents within the target communities did not recognize the frequency and intensity of climate change. Most notably, although salinity was widely recognized as a significant problem for the community – agriculture, fisheries, biodiversity, trees, and plants, are all highly vulnerable – very few perceived an increased risk due to climate change. This suggests that communities do not predict perfectly an increased threat from these hazards and thus may not recognize the need to implement adaptation strategies further. In this research, the highest hazard score is 12, obtained by 100 families, illustrating that those families are in the most precarious position in terms of different climatic disasters the region faces. The table also elucidates that the hazard score of 12 is obtained by five families, illustrating that those families are in the most precarious position in terms of the region's different climatic disasters. The table also elucidates that the hazard score of forty-nine families is between 10 to 11.5, more than 25% of the total respondents. Forty-two families lie between 8.5–9.5, 43% of the total Respondent. The rest of the four respondents' score lies between 5.5-8, 3.56% of the total respondents.
Potato Fermented Fertilizer Modulates Soil Nitrification by Shift Niche of Functional Microorganisms to Increase Yield in North China
Authors: Zhang Qichun , Gong Longda , Abbas Touqeer , Wu Dan , He Dan , Di Hongjie 
Published: February 2022

Abstract
Aims
Potato starch wastewater contains higher contents of essential nutrients, which can be feritilizer to help crop growth. However, the effects of potato fermented fertilizer on soil ecology and soil microbial community structure have not yet been elucidated. The objective of this study was to investigate the shifts of active ammonia oxidation microbial communities under different fertilization in a typical soil from North China.
Methods
The different levels of potato fermented fertilizer without or with chemical fertilizer were designed by field experiment.
Results
The results showed that the application of potato fermented fertilizer could significantly increase crop yields by 165–399% compared to Control. The content of available soil nutrients and the activity of saccharase and cellulase were increased when potato fermented fertilizer was applied, and the combination fertilizers further increased the content of Olsen-P by 145.6-166.7%, NO3− by 15.2–81.1%, Total C by 13.8–14%, and Total N by 27.2–34.7% compared with potato fermented fertilizer (PW) treatments. Furthermore, the fermented potato fertilizer significantly stimulated the diversity of soil microbial community, and increased the differentiation and stability of soil microbial networks in deep soils. Finally, the change of niche of soil Comammox(COM), ammonia-oxidizing archaea (AOA), and ammonia-oxidizing bacteria (AOB) was found after PW treatments, showed a significant positive correlation between AOA and COM (r = 0.79, P < 0.01), AOB and NOB (r = 0.7, P < 0.05) instead of theoretically the competitive relationship between AOA and COM.
Conclusions
Potato fermented fertilizer modulates soil nitrification strategy by change the niche of soil functional microorganisms to increase fast-acting nutrients and increase crop yield.