bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Complex Methodological Approach for the Screening of Efficient and
Safe Cobalt Chelators
Authors: Moravcová Monika , Hrubša Marcel , Lomozová Zuzana , Catapano Maria Carmen , Argento Roberta , Jirkovský Eduard , Kučera Radim , Mercolini Laura , Mladěnka Přemysl 
Published: October 2022

Background::
Cobalt is an essential trace element, but it can also rarely cause cobalt toxicity
due to its release from cobalt-containing medical devices. Currently, there are no approved selective
cobalt chelators, which would represent an optimal treatment modality.

Objective::
This study aimed to develop a simple and complex methodological approach for screening
potential cobalt chelators and evaluating their potential toxicity.

Methods::
Firstly, a simple spectrophotometric assay employing 1-nitroso-2-naphthol-3,6- disulfonic
acid disodium salt (NNDSA) for screening cobalt chelation was standardized at a pathophysiologically
relevant range of pH 4.5-7.5. Then, the suitability of the method was verified using four known
metal chelators (EDTA, 8-hydroxyquinoline, chloroxine and nitroxoline). As cobalt can catalyse the
Fenton reaction, the potential toxicity of cobalt-chelator complexes was also determined by employing
a novel HPLC method with coulometric detection. The effect on erythrocyte haemolysis was
tested as well.

Results::
The NNDSA method had high sensitivity enabling the detection of 25-200 nM of cobalt
ions depending on pH conditions. Measurements could be carried out in a wide range of wavelengths
from 470 to 540 nm. All tested complexes of the selected chelators decreased the rate of the Fenton
reaction. Interestingly, chloroxine mixed with cobalt ions caused marked lysis of erythrocytes in
contrast to the other compounds.

Conclusion::
The described complex methodological approach could serve as a simple yet precise
tool for evaluating novel, effective and safe cobalt chelators.
Dynamic Viscosity-Temperature Characteristics and Models of Various
Lubricating Oils
Authors: Wang Yanshuang , Gao Xudong , Shen Yuhai , Lin Jianghai 
Published: October 2022

Background:
The dynamic viscosity - temperature characteristics of lubricants are the main factors used to determine the oil film thickness and carrying capacity. There are few studies on the factors affecting the dynamic viscosity-temperature characteristics of lubricating oils and the dynamic viscosity-temperature model.

Objective:
This research aims to analyse the influences of lubricating oil type and initial kinematic viscosity on dynamic viscosity - temperature characteristics and present a new dynamic viscosity - temperature model.

Methods:
The characteristic curves of dynamic viscosity versus temperature of polyol ester oil, paraffinic mineral oil, and five types of PAO (poly a-olefin) oils with different initial viscosities were obtained by using a kinematic viscosity test device and a density test device. The influences of lubricating oil type and lubricating oil viscosity on dynamic viscosity - temperature characteristics were analysed. Based on our patent technology and repeated verification, a new dynamic viscosity - temperature model was presented.

Results:
Viscosity - temperature curves of three different types of lubricating oils and viscosity - temperature curves of PAO oils with different initial kinematic viscosities were obtained. A new dynamic viscosity - temperature model η=A×e^(((-T)/n) )⁡+ η_0 was proposed.

Conclusion:
The dynamic viscosity - temperature characteristics of lubricating oils are not only determined by the type of oils but also determined by the initial kinematic viscosity.The variation of dynamic viscosity of lubricating oils with temperature in the scope of -40~110℃ can be described by the following viscosity temperature model : , which can be used in wider temperature range than the existing models.
Immunomodulatory Activity of Diterpenes over Innate Immunity and
Cytokine Production in a Human Alveolar Epithelial Cell Line Infected with
Mycobacterium tuberculosis
Authors: Castillo-Maldonado Irais , Pedroza-Escobar David , Hernández-Herrera Alejandro David , Luna-Herrera Julieta , del Rocío González-Martínez Marisela , Prieto-Hinojosa Adria I. , Turcios-Esquivel Ana Monica , Delgadillo-Guzmán Dealmy , Ramírez-Moreno Agustina , Bustos-Brito Celia , Esquivel Baldomero , Vega-Menchaca María-del-Carmen 
Published: October 2022

Background:
Mexico has the largest number of the genus salvia plant species, whose main chemical compounds of this genus are diterpenes, these chemical compounds have shown important biological activities such as: antimicrobial, anti-inflammatory and immunomodulatory.

Objective:
This study aimed to evaluate the immunomodulatory activity of three diterpenes: 1) icetexone, 2) anastomosine and 3) 7,20-dihydroanastomosine, isolated from Salvia ballotiflora, over innate immunity and cytokine production in a human alveolar epithelial cell line infected with Mycobacterium tuberculosis.

Method:
The immunomodulatory activity of diterpenes over innate immunity included reactive oxygen and nitrogen species (ROS and RNS) induction in response to infection; cytokine production included TNF-α and TGF-β induction in response to infection.

Results:
The diterpenes anastomosine and 7,20-dihydroanastomosine showed a statically significant (p<0.01) increase of RNS after 36 h of infection and treatment of 2.0 µg/mL. Then, the ROS induction in response to infection showed a consistent statically significant (p<0.01) increase after 12 h of diterpenes treatments. The cell cultures showed an anti-inflammatory effect, in the case of TGF-β induction, in response to infection when treated with the diterpenes. On the other hand, there was not any significant effect on TNF-α release.

Conclusion:
the diterpenes anastomosine and 7,20-dihydroanastomosine increased the production of RNS after 36 h of infection and treatment. Besides, the three diterpenes increased the production of ROS after 12 h. This RNS and ROS modulation can be considered as an in vitro correlation of innate immunity in response to Mycobacterium tuberculosis infection; and an indicator of the damage of epithelial lung tissue. This study also showed an anti-inflammatory immune response by means of TGF-β modulation when compared with control group.
Shortening the Time Interval for the Referral of Patients With Soft Tissue Sarcoma to Expert Centers Using Mobile Health: Retrospective Study
Authors: Nannini Simon , Penel Nicolas , Bompas Emmanuelle , Willaume Thibault , Kurtz Jean-Emmanuel , Gantzer Justine 
Published: October 2022

Background
According to guidelines, all patients with sarcoma must be managed from initial diagnosis at expert sarcoma centers. However, in everyday practice, the time interval to an expert center visit can be long, which delays presentation to an expert multidisciplinary tumor board and increases the risk of inappropriate management, negatively affecting local tumor control and prognosis. The advent of mobile health offers an easy way to facilitate communication and cooperation between general health care providers (eg, general practitioners and radiologists) and sarcomas experts. We developed a mobile app (Sar’Connect) based on the algorithm designed by radiologists from the French Sarcoma Group. Through a small number of easy-to-answer questions, Sar’Connect provides personalized advice for the management of patients and contact information for the closest expert center.

Objective
This retrospective study is the first to assess this mobile app’s potential benefits in reducing the time interval for patient referral to an expert center according to the initial clinical characteristics of the soft tissue tumor.

Methods
From May to December 2021, we extracted tumor mass data for 78 patients discussed by the multidisciplinary tumor boards at 3 centers of the French Sarcoma Group. We applied the Sar’Connect algorithm to these data and estimated the time interval between the first medical description of the soft tissue mass and the referral to expert center. We then compared this estimated time interval with the observed time interval.

Results
We found that the use of Sar’Connect could potentially shorten the time interval to an expert center by approximately 7.5 months (P<.001). Moreover, for half (31/60, 52%) of the patients with a malignant soft tissue tumor, Sar’Connect could have avoided inappropriate management outside of the reference center. We did not identify a significant determinant for shortening the time interval for referral.

Conclusions
Overall, promoting the use of a simple mobile app is an innovative and straightforward means to potentially accelerate both the referral and management of patients with soft tissue sarcoma at expert centers.
Pendidikan Kespro Wanita Penderita Polycystic Ovary Syndrome Melalui Media Sosial (Studi Akun Instagram @pcosfighter)
Authors: Sofian Akhriyadi , Ayuningtyas Safira , Safitri Ririh Megah 
Published: October 2022

Instagram adalah media sosial yang banyak digunakan oleh masyarakat Indonesia. Instagram banyak melahirkan komunitas-komunitas virtual yang banyak membagikan edukasi. Salah satunya adalah akun komunitas @pcosfighterindonesia yang membagikan edukasi pendidikan kesehatan reproduksi wanita. Artikel ini berdasar pada riset kualitatif dengan pendekatan kualitatif deskriptif. Metode yang digunakan adalah netnografi dengan analisa media siber. Metode analisa media siber menggunakan dua unit level makro (objek media berupa tindakan pemeliharaan kesehatan reproduksi akun @pcosfighterindonesia dan pengalaman berupa bagaimana dampak para followers setelah mengikuti beragam konten yang dibagikan) serta mikro (ruang media berupa akun komunitas @pcosfighterindonesia dimana terjadinya interaksi dan dokumen media berupa alat berkomunikasi secara virtual yang digunakan kepada followers) yang dapat memberikan gambaran komunitas dalam media virtual. . Hasil dari penelitian ini menunjukkan terjadinya tindakan pemeliharaan kesehatan wanita penyandang PCOS oleh followers mereka. Tindakan ini dilakukan setelah mereka mendapatkan edukasi melalui konten-konten yang dibagikan oleh akun @pcosfighterindonesia.
Growth Performance of Wistar Rats Fed Graded Levels of Piper umbellatum Linn (Cow-Foot) Leaf Meal
Authors: Baradum Sor-Aniabari Ruth , Peters Dikioye Emmanuel , Ohiri Reginald Chibueze , Ogunka-Nnoka Charity Uchechi 
Published: October 2022

The growth performance of albino rats fed graded levels of Piper umbellatum Linn leaf meal (PULM) was evaluated. Twenty individually-housed albino weanling rats were divided into four groups of five rats each and fed with three graded levels of PULM inclusion diets (10%, 15% and 20%) labeled groups T1, T2, and T3 respectively and T0 for control. Growth performance was monitored for 21 days. Growth performance revealed total reduction in body weight of rats on day 7 in all groups. Mean weights of rats non significantly increased in groups T1 and T2 and decreased in group T3 on days 14 and 21 while group T0 increased significantly (p≤0.05) on day 21 when compared with initial weights. Feed intake in all groups decreased significantly (p≤0.05) while feed conversion ratio (FCR) decreased significantly (p≤0.05) only in group T3 when compared with the control. Carcass weights (heart, liver and intestine) for groups T1-T3 and kidney for groups T2 and T3 significantly (p≤0.05) decreased when compared to control. The present study hence revealed that inclusion of Piper umbellatum Linn leaf meal in the rat’s diet had reduction effects on body weight, feed intake, feed conversion ratio (FCR) and carcass weights of the rats. Hence, PULM could serve as a novel food source for body weight management.
HUBUNGAN PATRON-KLIEN PADA KOMUNITAS NELAYAN DALAM KERANGKA EKONOMI ISLAM
Authors: Rusydi Bahrul Ulum , Wahyudi Wahyudi , Ulfa Marya 
Published: October 2022

Penelitian ini dilatar belakangi oleh hubungan antara Tengkulak dan nelayan kapal Bagan yang sudah banyak kita jumpai dalam kehidupan sehari-hari termasuk hubungan Tengkulak dan nelayan kapal Bagan yang ada di pulau Balang Caddi. Nelayan kapal bagan sebagai klien bekerjasama dengan tengkulak nelayan kapal bagan menjual hasil tangkapannya dan Tengkulak membeli hasil tangkapan nelayan. Tujuan penelitian ini untuk mengetahui penetapan harga yang Tengkulak terhadap hasil tangkapan nelayan kapal bagan dan untuk mengetahui bagaimana pandangan islam tehadap hubungan Tengkulak dan nelayan kapal Bagan.Jenis penelitian ini adalah penelitian kualitatif dengan menggunakan pendekatan penelitian yang digunakan adalah: historis dan normatif. Metode pengumpulan data yang digunakan observasi, wawancara, dan dokumentasi lalu teknik pengolahan dan analisa data yaitu : reduksi data, penyajian data, dan penarikan kesimpulan atau vertifikasi.Hasil penelitian menunjukkan bahwa harga yang ditetapkan Tengkulak terhadap hasil tangkapan nelayan tidak sesuai dengan harga pasar yang ada sehingga merugikan pihak nelayan kapal bagan sebagai nelayan kapal Bagan yang menjual hasil tangkapannya kepada Tengkulak. Implikasi dari penelitian ini yaitu melalui penelitian yang diharapkan mampu menjadi salah satu solusi dalam menyelesaikan masalah ekonomi, terutama kesejahteraan nelayan. Bagi pemerintah setempat agar hasil penelitian ini dapat dijadikan masukan atau acuan pengambilan kebijakan dalam menentukan harga pasar pada pasar lelong Makassar.
IMPLEMENTASI AKAD SALAM PADA PERUSAHAN RETAIL DI TASIKMALAYA
Authors: Dede Aji Dede Aji , Abduh Muhammad 
Published: October 2022

AbstractThe online market phenomenon raises a new problem, namely the discrepancy between goods, quality and delivery time, so that it can cause losses and unfairness in business competition. The method approach used is qualitative by interviewing three large companies as providers of community needs. The results of the study indicate that transactions carried out using a salam contract are in accordance with the rules of Islamic law, because they have fulfilled the antarodin principle and there is a fulfillment of rights and obligations between the seller and the buyer..AbstrakFenomena pasar online memunculkan masalah baru adalah ketidaksesuaian antara barang, kualitas dan waktu penyerahan, sehingga dapat menimbulkan kerugian dan ketidaksehatan dalam persaingan usaha.Tujuaan penelitian untuk menganalisis jual beli akad salam yang dilakukan perusahaan di Tasikmalaya. Pendekatan metode yang digunakan adalah kualitatif dengan teknik wawancara tiga perusahaan besar sebagai penyedia kebutuhan masyarakat. Hasil penelitian menyebutkan bahwa transaksi yang dilakukan dengan menggunakan akad salam adalah sesuai dengan kaidah hukum Islam, karena telah memenuhi prinsip antarodin dan terdapat pemenuhan antara hak dan kewajiban antara penjual dan pembeli.
Flipped Learning: Asynchronous and Synchronous Models in Online Class to Improve the Learning Outcomes
Authors: Hartina St , Ermawati Ermawati , Syahrir Syahrir 
Published: October 2022

Flipped learning is a strategy for assisting the online learning process. This study attempts to adopt it in an online class using a quasi-experimental design with a post-test-only control to examine its effects on student learning outcomes. Data was obtained from reading tests administered to students enrolled in the fifth semester of the English Education Department at IAIN (State Islamic Institute) of Palopo. This study discovered at least three findings suggesting that flipped learning improves student learning outcomes significantly. First, students' mean score in the experimental class is higher (x = 70.11) than in the control class (x = 58.70). Second, the significance value (Sig. 2-tailed) is 0.000<0.05, indicating a significant effect of the experimental class implementation of flipped learning. Third, the effect size is 1.106 with an influence percentage of 86 percent which categorized has a large effect based on Cohen’s criteria. The author proposes utilizing a flipped learning technique as a substitute for online learning in light of the findings.
The Interrelation of Language Learning Strategies and English Proficiency among Medical Students
Authors: Ahsanah Finaty , Utomo Dias Tiara Putri 
Published: October 2022

This study investigated language learning strategies used by medical students and its relation to students’ English proficiency. The study was conducted at Universitas Muhammadiyah Lamongan, the participant involved in this study were 74 medical students from three different departments; physiotherapy, midwifery, and pharmacy. The language learning strategies data were obtained from the Oxford’s Strategy Inventory for Language Learning (SILL), while the English proficiency level was obtained from the students’ EPT scores. Data analysis was carried out using SPSS – descriptive statistics and Pearson Correlation. The findings revealed that the participants frequently used strategies were memory strategies by the mean of 3.11, followed by metacognitive strategies at 3.06, cognitive strategies at 2.97, social strategies at 2.95, compensation strategies at 2.94, and affective strategies at 2.91. Meanwhile, the Pearson Correlation or ŕ value was .054 ≤ 0.05, and the sig. (2 tailed) value was .064 ≥ 0.05. It can be concluded that there was no interrelation between the use of language learning strategies and students’ English proficiency. Therefore, students’ English proficiency does not affect language learning strategies preference. The findings of this current study might be useful as input for English teachers and learners to build an effective classroom environment.
Students' Speaking Anxiety during Online Learning: Causal Factors and Strategies to Overcome Them (A Narrative Inquiry Study at Islamic Senior Secondary School (MAN) Insan Cendekia Gowa)
Authors: Nur Muhammad Alauddin , Baa Sultan 
Published: October 2022

Anxiety has been considered as one of the obstacles in learning English and a common issue in the EFL teaching and learning. In speaking, it also debilitates the opportunity of English Foreign Language (EFL) students to speak English. Several studies have been conducted to discover the causes and straegies to overcome them in traditional classroom. To date, not many studies have focused on students’ anxiety in online learning. Therefore, this study was designed to reveal the causal factors of the students’ speaking anxiety and strategies to overcome them during online learning at Islamic senior secondary school setting. The study employed narrative inquiry approach and used interview as the main instrument of data collection. Four students of Islamic Senior Secondary School (MAN) Insan Cendekia Gowa whom selected to be the participants of the study using purposive sampling technique. The result of this study establishes two main findings. Firstly, the causal factors of students' speaking anxiety during online learning were divided into internal and external factors. The internal factors consisted of lack of confidence, shyness, fear of making mistake, and feeling insecure. The external factors consisted of lack of preparation, limited vocabulary, friends or classmates, embarrassment, teachers’ teaching style. The study found that the external factors are indicated as the most dominant causes of students' speaking anxiety. Furthermore, the study highlights several strategies used by the students to overcome their speaking anxiety, namely: good preparation (lecture note), peer seeking, keeping silent or calm, practice speaking at home, turning the camera off, using ‘google translator’, and limiting speaking duration.
The Teaching English of English Grammar based on the 2013 Curriculum
Authors: Nurbiana Nurbiana 
Published: October 2022

This study aims at investigating the teachers’ strategies in teaching English grammar based on the 2013 Curriculum. The subject of this research are two English teachers at SMPN 11 Maros Baru. This study is conducted by qualitative design and is focused on the phenomenon method. The findings shows that the strategies applied by the teachers in teaching grammar based on the 2013 Curriculum are problem based learning, project and blended learning. meanwhile, the problems faced by the teachers when implementing the 2013 Curriculum are related to time, the learners’ selfconfident, the internet networking, and the learning resources. As the result, the findings elucidate that most of the teachers apply the 2013 Curriculum in their teaching process. although it was not deeply in the using. The teachers use discovery based learning, project based learning and problem based learning as the main strategy in their teaching and learning process. The problems faced by the English teacher when in implementing the 2013 Curriculum were related to time, the learners unconfident, the internet networking and the pedagogy technology competence.
The Reason of Performing Code-switching and Code-mixing in Indonesian – English by the Elite People in Makassar
Authors: Baharuddin Baharuddin 
Published: October 2022

This article aimed at finding out reasons of code switching by the elite people. The data were obtained through questionnaire. The population was the elite people in Makassar who were divided into five groups namely doctors, government officials, lawyers, lecturers, and politicians living in Makassar. There were 100 conversation produced by 25 respondents. Those 25 respondents were asked to complete a questionnaire about their reason in codeswitching. The analysis of data in this research was carried out through the following the procedures: (1) The data were classified based on the criteria of reason (2) The discourse of code switching reasons was tabulated (3) The reasons of code switching were described. The result show that in term of the reasons of code switching, it is found three reasons; practicality of English, good ability of English, and lack of Indonesian expressions
Developing advanced therapeutics through the study of naturally occurring immune-mediated ocular disease in domestic animals
Authors: Gilger Brian C. 
Published: October 2022

ABSTRACT
This review, which is part of the “Currents in One Health” series, describes the importance of the study of immune-mediated ocular disease in the development of innovative therapeutics, such as cell and gene therapy for the eye. Recent examples of cell and gene therapy studies from the author’s laboratory are reviewed to emphasize the importance of One Health initiatives in developing innovative therapies for ocular diseases. Spontaneous immune-mediated corneal disease is common in horses, cats, dogs, and humans. Autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) injected subconjunctivally resulted in the resolution of naturally occurring immune-mediated keratitis (IMMK) without adverse effects. These results support that autologous subconjunctival BM-MSC therapy may be a viable treatment alternative for IMMK. Furthermore, the use of subconjunctival MSCs may be an effective method to treat ocular surface immune-mediated diseases in humans and other species, including herpetic stromal keratitis and immunologic dry eye disease. Furthermore, the use of adeno-associated viral (AAV) vectors to deliver the immunosuppressive transgene cDNA of equine interleukin 10 (eqIL-10) or human leukocyte antigen G injected intravitreally was shown to be safe and inhibited the development of uveitis in the experimental autoimmune uveitis rat model. Efficacy and safety studies of ocular gene therapy in models will pave the way for clinical trials in animals with naturally occurring immune-mediated diseases, such as a therapeutic clinical trial for AAV-eqIL-10 in horses with equine recurrent uveitis.