bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating sustainable development for the COVID-19 vaccine supply chain: a structural equation modelling approach
Authors: Mukherjee Subhodeep , Baral Manish Mohan , Chittipaka Venkataiah , Pal Surya Kant , Nagariya Ramji 
Published: May 2022

PurposeImmunization is one of the most cost-effective ways to save lives while promoting good health and happiness. The coronavirus disease 2019 (COVID-19) pandemic has served as a stark reminder of vaccines' ability to prevent transmission, save lives, and have a healthier, safer and more prosperous future. This research investigates the sustainable development (SD) of the COVID-19 vaccine supply chain (VSC).Design/methodology/approachThis study investigates the relationship between internal process, organizational growth, and its three pillars of SD environmental sustainability, economic sustainability and social sustainability. Survey-based research is carried out in the hospitals providing COVID-19 vaccines. Nine hypotheses are proposed for the study, and all the hypotheses got accepted. The survey was sent to 428 respondents and received 291 responses from health professionals with a response rate of 68%. For the study, the healthcare professionals working in both private and public hospitals across India were selected.FindingsThe structural equation modelling (SEM) approach is used to test the hypothesis. All nine hypotheses are supported. This study examines a link between internal processes and organizational learning and the three sustainability pillars (environmental sustainability, economic sustainability and social sustainability).Practical implicationsThis study will help the management and the policymakers to think and adopt SD in the COVID-19 VSC. This paper also implies that robust immunization systems will be required in the future to ensure that people worldwide are protected from COVID-19 and other diseases.Originality/valueThis paper shows the relationship between organizational learning and internal process with environmental sustainability, economic sustainability and social sustainability for the COVID-19. Studies on VSC of COVID-19 are not evident in any previous literature.
The regulatory failure of spatial planning and its environmental impact: a case study of hotel projects in Bali, Indonesia
Authors: Widiatedja I Gusti Ngurah Parikesit 
Published: May 2022

Purpose
This paper aims to explain the impact of spatial planning regulations in the development of hotels in Bali, particularly as regards environmental damage. It then analyzes the factors that cause spatial planning to fail to prevent environmental damage.

Design/methodology/approach
This paper is based on both fieldwork and library research, and a broadly socio-legal approach is adopted, involving a combination of doctrinal research and empirical legal method.

Findings
This paper finds that interrelated legal, political and economic factors contribute to this failure, including conflicting regulations on the review and amendment of spatial plans, the pursuance of economic enrichment and an unsustainable approach to economic development. Although some or even all of these factors may have seemed obvious from the start, because they are common causes of regulatory failure, this paper demonstrates empirically that they are exacerbated and made more challenging because of the interrelationship between legal, political and economic factors.

Research limitations/implications
Given the existence of intertwined legal, political and economic factors behind the regulatory failure of spatial planning, more studies need to be undertaken to restore spatial planning objectives as a means of preventing tourism projects in Bali from damaging the environment.

Originality/value
The author proposes a reform to make spatial planning regulations more effective, particularly in preventing environmental damage by tourism projects.
Analyzing the impact of technology incentives on community digital inclusion using structural equation modeling
Authors: Islam A.Y.M. Atiquil , Rafi Muhammad , Ahmad Khurshid 
Published: May 2022

PurposeThis study aims to assess whether technological incentives inspire communities in the process of digital inclusion. The factors analyzed by the authors assess five dimensions: technology incentives, technology utilization, searching skills, social integration, and capabilities.Design/methodology/approachData were collected from 329 respondents in 14 public libraries and analyzed using structural equation modeling to validate the proposed research model and its relationships with the factors the authors analyzed.FindingsThe results showed that technological incentives significantly impact on technology utilization, searching skills, social integration, and capabilities to support community digital inclusion in Pakistan.Practical implicationsTechnological incentives to the community will lead to the improvement of network technology for things like online taxation, banking transactions, social integration, participation in government, and modern health and education benefits. In addition, technological incentives will also enhance information literacy and digital access, helping people improve cognitive skills and critical thinking and also helping to develop skills.Originality/valueThis research is based on raw data first collected from various people with different opinions from the Khyber Pakhtunkhwa public libraries. This study was conducted to gain a deeper understanding of the overall situation related to the use of technology in Pakistan and the complications involved.
Emergency learning during the COVID-19 pandemic: experiences and reflections from a virtual community of practice
Authors: Enriquez Silvia Cecilia , Gargiulo Sandra Beatriz 
Published: May 2022

Purpose
This study aims to reflect on the effects of the COVID-19 pandemic on education and draw some tentative assumptions from the information and experiences gathered from participants in this community about their possible impact on the future of education.

Design/methodology/approach
This study uses a single-case descriptive case study that analyses some indicators of changes in teaching and learning that have taken place to date in the pandemic period as seen from Docentes en línea, a virtual community of practice of the Universidad Nacional de La Plata, Argentina.

Findings
A number of shortcomings in the educational system, technological infrastructure and teacher formation in many of our members’ countries. Concurrently, rising interest in the use of information and communication technology (ICT) in education and a new awareness of possible changes.

Research limitations/implications
Part of the data comes from informal sources; therefore, they cannot be completely systematised or quantified. Besides, the results are provisional because the pandemic has not ended.

Originality/value
This analysis was conducted on the basis of first-hand data collected in the activity developed by the members of this virtual community of practice. There is little research on this type of activity at the moment.
Facilitating transformative science education through futures thinking
Authors: Laherto Antti , Rasa Tapio 
Published: May 2022

Purpose
The aims and pedagogies in the field of science education are evolving because of global sustainability crises. School science is increasingly concerned with responsible agency and value-based transformation. The purpose of this conceptual paper is to argue that perspectives and methods from the field of futures studies are needed to meet the new transformative aims of science education for sustainable development.

Design/methodology/approach
This paper analyses some contemporary challenges in science education and gives reasons for introducing a futures perspective into science classrooms. The suggestion is illustrated by reviewing some results, published elsewhere, on future-oriented activities trialled within the European Union project “I SEE” and students’ experiences on them.

Findings
Recent research has shown that future-oriented science learning activities, involving systems thinking, scenario development and backcasting, can let students broaden their futures perceptions, imagine alternatives and navigate uncertainty. Practising futures thinking in the context of contemporary science offers synergies through shared perspectives on uncertainty, probabilities and creative thinking.

Originality/value
This paper highlights the relevance of the futures field for science education. Future-oriented activities appear as promising tools in science education for fostering sustainability, agency and change. Yet, further work is needed to integrate futures aspects into science curricula. To that end, the paper calls for collaboration between the fields of futures studies and science education.
Perceptions of living wage impacts in Aotearoa New Zealand: towards a multi-level, contextualised conceptualisation
Authors: Parker Jane , Arrowsmith James , Young-Hauser Amanda , Hodgetts Darrin , Carr Stuart Colin , Haar Jarrod , Alefaio-Tugia Siatu 
Published: May 2022

PurposeThe study maps workplace stakeholders’ perceptions of living wage (LW) impacts in New Zealand. Empirical findings inform an inaugural model of LW impacts and contingent factors at individual, organisation, sector/industry and national levels.Design/methodology/approachData from a national employee survey, semi-structured interviews with business sector representatives, and staff in two LW organisation cases were subjected to thematic content analysis.FindingsInformants emphasised anticipated LW impacts amid complex workplace and regulatory dynamics. Employers/managers stressed its cost effects. However, employees, human resource (HR) advocates and other LW proponents highlighted employee “investment” impacts that improve worker productivity and societal circumstances.Research limitations/implicationsThis study highlights the need for further context-sensitive LW analysis. An initial model of LW impacts provides a framework for comparative and longitudinal work in other national contexts.Practical implicationsThe proposed model categorises perceived LW effects and can inform policy development. Findings also stress a need for cross-agency initiatives to address LW concerns, including a key role for HR.Social implicationsThe findings highlight perceptions of a LW impacting within and beyond the workplace. Whilst higher-quality management is seen to encourage better-informed decisions about “going living wage”, a LW's positive socio-economic impacts require multi-lateral initiatives, suggesting that those initiatives are is part of wider obligations for policy makers to encourage decent living standards.Originality/valueThis study provides a much-needed and inaugural focus on the intertwined workplace and wider impacts of a LW, extending extant econometric analyses. The paper also synthesizes different data sources to develop an inaugural, context-sensitive model of perceived LW effects.
Activity recognition on smartphones using an AKNN based support vectors
Authors: Abidine M'hamed Bilal , Oussalah Mourad , Fergani Belkacem , Lounis Hakim 
Published: May 2022

Purpose
Mobile phone-based human activity recognition (HAR) consists of inferring user’s activity type from the analysis of the inertial mobile sensor data. This paper aims to mainly introduce a new classification approach called adaptive k-nearest neighbors (AKNN) for intelligent HAR using smartphone inertial sensors with a potential real-time implementation on smartphone platform.

Design/methodology/approach
The proposed method puts forward several modification on AKNN baseline by using kernel discriminant analysis for feature reduction and hybridizing weighted support vector machines and KNN to tackle imbalanced class data set.

Findings
Extensive experiments on a five large scale daily activity recognition data set have been performed to demonstrate the effectiveness of the method in terms of error rate, recall, precision, F1-score and computational/memory resources, with several comparison with state-of-the art methods and other hybridization modes. The results showed that the proposed method can achieve more than 50% improvement in error rate metric and up to 5.6% in F1-score. The training phase is also shown to be reduced by a factor of six compared to baseline, which provides solid assets for smartphone implementation.

Practical implications
This work builds a bridge to already growing work in machine learning related to learning with small data set. Besides, the availability of systems that are able to perform on flight activity recognition on smartphone will have a significant impact in the field of pervasive health care, supporting a variety of practical applications such as elderly care, ambient assisted living and remote monitoring.

Originality/value
The purpose of this study is to build and test an accurate offline model by using only a compact training data that can reduce the computational and memory complexity of the system. This provides grounds for developing new innovative hybridization modes in the context of daily activity recognition and smartphone-based implementation. This study demonstrates that the new AKNN is able to classify the data without any training step because it does not use any model for fitting and only uses memory resources to store the corresponding support vectors.
Trifolirhizin regulates the balance of Th17/Treg cells and inflammation in the ulcerative colitis mice through inhibiting the TXNIP‐mediated activation of NLRP3 inflammasome
Authors: Zhang Qing , Wang Shufang , Ji Shanyun 
Published: May 2022

AbstractUlcerative colitis (UC) is a chronic and recurrent autoimmune disease, characterized by recurrence and remission of mucosal inflammation. Although the understanding of the pathogenesis of UC has been improved, effective therapeutic drugs are required for treating patients with UC. In current work, the mouse model of colitis was established. Trifolirhizin was demonstrated to improve symptom in dextran sulfate sodium (DSS)‐induced colitis mice. The body weight of mice was elevated, whereas the disease activity index (DAI) was reduced. Moreover, trifolirhizin was involved in inhibition of inflammation and regulation of the balance of T helper 17 (Th 17) cells and regulatory T (Treg) cells in DSS‐induced colitis mice. Further, the activation NLRP3 inflammasome was suppressed by trifolirhizin in DSS‐induced colitis mice. Trifolirhizin was also identified to regulate AMP‐activated protein kinase (AMPK)‐thioredoxin‐interacting protein (TXNIP) pathway. The trifolirhizin‐mediated anti‐inflammatory effect was inhibited by suppressing AMPK in DSS‐induced UC mice. In summary, the research suggested that administration of trifolirhizin significantly improved the symptoms and the pathological damage in DSS‐induced UC mice. Trifolirhizin regulated the balance of Th17/Treg cells and inflammation in the UC mice through inhibiting the TXNIP‐mediated activation of NLRP3 inflammasome.
Glaucocalyxin A induces apoptosis of non–small cell lung carcinoma cells by inhibiting the PI3K/Akt/GSK3β pathway
Authors: Zhang De , Deng Ting , Yuan Wa , Chen Tongqiang , Jiang Shuping 
Published: May 2022

AbstractLung cancer is one of the fastest growing malignancies in morbidity and mortality, and current therapies are in general not sufficiently effective for this deadly disease. This study characterizes the anticancer effects of glaucocalyxin A (GLA) and explores the underlying mechanisms using human non‐small cell lung carcinoma (NSCLC) cells. First, our data showed that GLA suppressed the viability of cancer cells, whereas no effect was observed in the normal bronchial epithelial cell BEAS‐2B cells. Second, GLA inhibited colony formation, induced apoptosis of cancer cells. Third, GLA downregulated the expression of B‐cell lymphoma‐2 (Bcl‐2) protein; upregulated the expression of Bcl2‐associated X protein (Bax), and strengthened cleavage of caspase 3 and polyadenyl diphosphate ribose polymerase (PARP). Fourth, GLA also diminished mitochondrial membrane potential and inhibited phosphatidylinositol 3‐kinase (PI3K)/Akt/ glycogen synthase kinase‐3β (GSK3β) pathway. In addition, injection of GLA (20 mg/kg) every 2 days significantly inhibited A549 xenograft tumour growth, accompanied by increased apoptosis and decreased proliferation. Together, our study provides evidence that the anticancer effect of GLA in NSCLC is mediated by inducing apoptosis through inhibiting PI3K/Akt/GSK3β pathway and suggests that GLA may be used as a promising natural medicine for NSCLC therapy.
Attitudes and regard for specific medical conditions among Australian emergency medicine clinicians
Authors: Howard Stuart , Akhlaghi Hamed , Watson Tess , O'Reilly Gerard M , Karro Jonathan 
Published: May 2022

AbstractObjectiveTo quantify the attitude ED clinicians hold towards patients presenting with different medical conditions, including a novel pandemic condition.MethodsA cross‐sectional study of emergency doctors and nurses utilising the Medical Condition Regard Scale (MCRS); a validated tool used to capture the bias and emotions of clinicians towards individual medical conditions. The five conditions presented to participants each represent a classical medical, complex medical, psychiatric/substance use, somatoform and a novel medical condition.ResultsOne hundred and ninety‐six clinicians were included in the study including 116 nurses and 80 doctors. Concerning each condition, both medical and nursing staff demonstrated the highest regard for a classical medical condition (58 ± 5 and 57 ± 6, respectively). Significantly different from the classical medical condition, the lowest MCRS scores were for the somatoform condition (36 ± 10) for emergency doctors and the substance use condition (39 ± 11) for emergency nurses. Regard for a novel condition (i.e., COVID‐19 infection) was comparably high among both cohorts.ConclusionEmergency doctors and nurses generally hold lower regard for complex medical conditions with behavioural components, including substance use disorders and somatoform conditions.
Comparison of materials for rapid passive collection of environmental DNA
Authors: Bessey Cindy , Gao Yuan , Truong Yen Bach , Miller Haylea , Jarman Simon Neil , Berry Oliver 
Published: May 2022

AbstractPassive collection is an emerging sampling method for environmental DNA (eDNA) in aquatic systems. Passive eDNA collection is inexpensive and efficient, and requires minimal equipment, making it suited to high‐density sampling and remote deployment. Here, we compare the effectiveness of nine membrane materials for passively collecting fish eDNA from a 3‐million‐litre marine mesocosm. We submerged materials (cellulose, cellulose with 1% and 3% chitosan, cellulose overlayed with electrospun nanofibres and 1% chitosan, cotton fibres, hemp fibres, and sponge with either zeolite or active carbon) for intervals between 5 and 1080 min. We show that for most materials, with as little as 5 min of submersion, mitochondrial fish eDNA measured with qPCR, and fish species richness measured with metabarcoding, was comparable to that collected by conventional filtering. Furthermore, PCR template DNA concentrations and species richness were generally not improved significantly by longer submersion. Species richness detected for all materials ranged between 11 and 37 species, with a median of 27, which was comparable to the range for filtered eDNA (19–32). Using scanning electron microscopy, we visualized biological matter adhering to the surface of materials, rather than entrapped, with images also revealing a diversity in size and structure of putative eDNA particles. eDNA can be collected rapidly from seawater with a passive approach and using a variety of materials. This will suit cost‐ and time‐sensitive biological surveys, and where access to equipment is limited.
Liquid biopsy assay for pulmonary adenocarcinoma using supernatants from core‐needle biopsy specimens
Authors: Kong Fanlei , Li Yuanming , Guo Runqi , Yang Li , Di Jing , He Lei , Wang Zheng , Liu Dongge , Li Xiaoguang 
Published: May 2022

AbstractBackgroundGenomic testing is the cornerstone of the treatment of patients with non‐small‐cell lung cancer. However, comprehensive molecular testing of small specimens may be inadequate due to limited tissue. Liquid biopsy has emerged as a new method of genotyping. In this study, we evaluate the feasibility of using supernatants from core needle biopsy samples of lung adenocarcinoma for genomic testing.MethodsCore needle biopsy specimens and their supernatants were collected from patients (n = 48) with lung adenocarcinoma. Genomic testing results of the supernatant samples were compared with results derived from paired tissue samples from the same patient.ResultAll 48 supernatant samples yield adequate cell‐free DNA, but the concentration of cell‐free RNA did not meet the criteria for analysis. The concordance rate between the genomic testing results of supernatants and the corresponding tissue samples was 95.8% (kappa = 0.899). The coincidence rate of detectable mutations at the DNA level in the supernatants was up to 100%.ConclusionCore needle biopsy supernatants can provide a valuable specimen source for genotyping pulmonary adenocarcinoma. However, the method of preserving and extracting RNA from supernatant specimens needs further improvement.
Intra‐annual variation in activity budgets of a wild Chilean Flamingo (Phoenicopterus chilensis) population in Southern Brazil
Authors: Delfino Henrique Cardoso , Carlos Caio José 
Published: May 2022

AbstractAssessing animal behaviour is essential for understanding their relationship with the environment and assisting in the management and conservation of species in natural habitats, especially those that present large range distribution and occupy very dynamic environments. The Chilean Flamingo (Phoenicopterus chilensis, Aves: Phoenicopteridae) breeds in the temperate regions of South America, going from Ecuador to the south of Argentina, but moves to regions on the southern coast of Brazil and Uruguay during the non‐breeding season. To understand activity patterns and behavioural variations on wild Chilean Flamingos in Brazil, we carried out monthly field trips to the Lagoa do Peixe National Park, on the middle coast of Rio Grande do Sul state, between May and November 2019, totalling 99.8 total hours of observation. Forty‐one different behaviours were detected, divided into six categories: Feeding, Locomotion, Resting, Preening, Social Agonist and Social Non‐Agonist. A significant variation in frequency, total duration and mean duration was detected for the behavioural categories over the months, mainly in the social categories, possibly indicating a strong influence of climatic aspects, such as temperature, rainfall and wind, but also of population aspects, such as flock density and stage of the reproductive cycle, in the behaviours observed in the lagoon. We also detected a variation in behavioural richness and active behaviours among the months, indicating that contranuptial areas like Lagoa do Peixe can be used for more than only feeding and resting.