bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perancangan Sistem Fire Alarm Kebakaran Pada Gedung Laboratorium XXX
Authors: Ruslan Muhammad , Al-Amin M.Saleh , Emidiana Emidiana 
Published: January 2022

Abstract

Fire is a phenomenon that occurs when a material reaches a critical temperature and reacts chemically with oxygen (for example) producing heat, flame, light, smoke, water vapor, carbon monoxide, carbon dioxide, or other products and effects. Fires can occur anywhere, be it in office buildings, residences or public facilities. As for other than in public areas, fires often occur, both in rooms and laboratories, the triggers are almost the same due to negligence and not being careful in using flammable tools. For this reason, the need for a fire detector with a detector system using an alarm so that once a fire occurs, all those in the building can find out through the detector with an alarm sound as a fire marker. In order to reduce casualties, the need for a sprinkler system to extinguish the fire, and can assist the officers or authorities in the building as soon as possible. From the above problems, this research will determine how many detectors and sprinklers are needed, as well as how much water volume, pump power, and ground water tank are needed. This type of research is quantitative research by direct observation of the object under study, then researchers measure the room one by one using a building meter. From the calculation results by taking a sample on the 1st floor, the number of detectors needed is 10 smoke detectors and 3 heat detectors, the number of sprinklers is 47, the volume of water needed is 846 m3, the pump power and ground water tank needed are hydraulic power. pump (HHP) 3,28621 kW, pump shaft power (BHP) 4.38 kW, pump electric power (P) 6 kW, diesel pump (PpD) 4 HP, jocky pump (PJk) 0.6 kW, capacity GWT ( QGWT) 44 m3.
Finite groups with given systems of generalised σ-permutable subgroups
Authors: Zakrevskaya Viktoria S. 
Published: December 2021

Let σ = {σi|i ∈ I } be a partition of the set of all primes ℙ and G be a finite group. A set ℋ of subgroups of G is said to be a complete Hall σ-set of G if every member ≠1 of ℋ is a Hall σi-subgroup of G for some i ∈ I and ℋ contains exactly one Hall σi-subgroup of G for every i such that σi ⌒ π(G) ≠ ∅. A group is said to be σ-primary if it is a finite σi-group for some i. A subgroup A of G is said to be: σ-permutable in G if G possesses a complete Hall σ-set ℋ such that AH x = H  xA for all H ∈ ℋ and all x ∈ G; σ-subnormal in G if there is a subgroup chain A = A0 ≤ A1 ≤ … ≤ At = G such that either Ai − 1 ⊴ Ai or Ai /(Ai − 1)Ai is σ-primary for all i = 1, …, t; 𝔄-normal in G if every chief factor of G between AG and AG is cyclic. We say that a subgroup H of G is: (i) partially σ-permutable in G if there are a 𝔄-normal subgroup A and a σ-permutable subgroup B of G such that H = < A, B >; (ii) (𝔄, σ)-embedded in G if there are a partially σ-permutable subgroup S and a σ-subnormal subgroup T of G such that G = HT and H ∩ T ≤ S ≤ H. We study G assuming that some subgroups of G are partially σ-permutable or (𝔄, σ)-embedded in G. Some known results are generalised.
The influence of the stereotypic forms of activity in mice behaviour in standard behavioural tests
Authors: Avimova Kseniya P. , Sandakov Dmitry B. 
Published: December 2021

Laboratory animals often develop abnormal repetitive (stereotypic) behaviour that can influence both physiology and behavioural test results. Such abnormal behaviours usually develop in suboptimal environment and increase over time. To explore the development of stereotypic forms of activity night home-cage behaviour of laboratory mice was analysed and collated with the behaviour in open field (OFT), hole-board (HBT) and tail suspension (TST) tests twice within 16 weeks. Mice expressed few stereotypies and their duration lessened over time from median 8.2 to 1.0 %. In contrast, grooming behaviour increased significantly from 29.5 to 49.6 %. Home-cage grooming correlated with the latency of locomotion start in OFT and with the immobility time in TST. Intensity and stability of stereotypic activity and grooming inf­luenced the duration of grooming in OFT: the mice with unstable stereotypies groomed more than others, and mice with the lowes home-cage grooming level also groomed in OFT the most. Intensity and stability of night grooming influenced the behaviour in TST: the mice with unstable level of grooming were the most mobile in this test. Abnormal home-cage activity may indicate impaired welfare, and that, in turn, may affect test activity, so researchers need to keep it in mind when planning animal behaviour experiments.
HDAC Inhibitor Titration of Transcription and Axolotl Tail Regeneration
Authors: Voss S. Randal , Smith Jeramiah J. , Cecil Raissa F. , Kabangu Mirindi , Duerr Timothy J. , Monaghan James R. , Timoshevskaya Nataliya , Ponomareva Larissa V. , Thorson Jon S. , Veliz-Cuba Alan , Murrugarra David 
Published: December 2021

New patterns of gene expression are enacted and regulated during tissue regeneration. Histone deacetylases (HDACs) regulate gene expression by removing acetylated lysine residues from histones and proteins that function directly or indirectly in transcriptional regulation. Previously we showed that romidepsin, an FDA-approved HDAC inhibitor, potently blocks axolotl embryo tail regeneration by altering initial transcriptional responses to injury. Here, we report on the concentration-dependent effect of romidepsin on transcription and regeneration outcome, introducing an experimental and conceptual framework for investigating small molecule mechanisms of action. A range of romidepsin concentrations (0–10 μM) were administered from 0 to 6 or 0 to 12 h post amputation (HPA) and distal tail tip tissue was collected for gene expression analysis. Above a threshold concentration, romidepsin potently inhibited regeneration. Sigmoidal and biphasic transcription response curve modeling identified genes with inflection points aligning to the threshold concentration defining regenerative failure verses success. Regeneration inhibitory concentrations of romidepsin increased and decreased the expression of key genes. Genes that associate with oxidative stress, negative regulation of cell signaling, negative regulation of cell cycle progression, and cellular differentiation were increased, while genes that are typically up-regulated during appendage regeneration were decreased, including genes expressed by fibroblast-like progenitor cells. Using single-nuclei RNA-Seq at 6 HPA, we found that key genes were altered by romidepin in the same direction across multiple cell types. Our results implicate HDAC activity as a transcriptional mechanism that operates across cell types to regulate the alternative expression of genes that associate with regenerative success versus failure outcomes.
Upregulation of T Cell Receptor Signaling Pathway Components in Gestational Diabetes Mellitus Patients: Joint Analysis of mRNA and circRNA Expression Profiles
Authors: Chen Yan-ming , Zhu Qiong , Cai Jie , Zhao Zhi-jia , Yao Bin-bin , Zhou Li-ming , Ji Lin-dan , Xu Jin 
Published: January 2022

ObjectiveGestational diabetes mellitus (GDM) is one of the most common complications of pregnancy, and its pathogenesis is still unclear. Studies have shown that circular RNAs (circRNAs) can regulate blood glucose levels by targeting mRNAs, but the role of circRNAs in GDM is still unknown. Therefore, a joint microarray analysis of circRNAs and their target mRNAs in GDM patients and healthy pregnant women was carried out.MethodsIn this study, microarray analyses of mRNA and circRNA in 6 GDM patients and 6 healthy controls were conducted to identify the differentially expressed mRNA and circRNA in GDM patients, and some of the discovered mRNAs and circRNAs were further validated in additional 56 samples by quantitative realtime PCR (qRT-PCR) and droplet digital PCR (ddPCR).ResultsGene ontology and pathway analyses showed that the differentially expressed genes were significantly enriched in T cell immune-related pathways. Cross matching of the differentially expressed mRNAs and circRNAs in the top 10 KEGG pathways identified 4 genes (CBLB, ITPR3, NFKBIA, and ICAM1) and 4 corresponding circRNAs (circ-CBLB, circ-ITPR3, circ-NFKBIA, and circ-ICAM1), and these candidates were subsequently verified in larger samples. These differentially expressed circRNAs and their linear transcript mRNAs were all related to the T cell receptor signaling pathway, and PCR results confirmed the initial microarray results. Moreover, circRNA/miRNA/mRNA interactions and circRNA-binding proteins were predicted, and circ-CBLB, circ-ITPR3, and circ-ICAM1 may serve as GDM-related miRNA sponges and regulate the expression of CBLB, ITPR3, NFKBIA, and ICAM1 in cellular immune pathways.ConclusionUpregulation of T cell receptor signaling pathway components may represent the major pathological mechanism underlying GDM, thus providing a potential approach for the prevention and treatment of GDM.
Lower Body Temperature Independently Predicts Delayed Cerebral Infarction in the Elderly With Ruptured Intracranial Aneurysm
Authors: Lin Hui , Wang Haojie , Xu Yawen , Lin Zhangya , Kang Dezhi , Zheng Shufa , Yao Peisen 
Published: January 2022

Purpose: To assess the correlation between admission body temperature and delayed cerebral infarction in elderly patients with ruptured intracranial aneurysm (IA).Methods: Patients with ruptured IA diagnosed between 2012 and 2020 were retrospectively analyzed. Patients were divided into a non-infarction and an infarction group based on the presence of cerebral infarction after treatment. The demographic and clinical information of the patients was gathered. Outcomes at the 3-month follow-up were assessed using the modified Rankin Scale. Correlation between admission body temperature and cerebral infarction was assessed using Spearman's rank correlation coefficient. A receiver operating characteristic (ROC) curve was used to assess the specificity and sensitivity of admission body temperature to predict cerebral infarction.Results: A total of 426 patients (142 men and 284 women) with ruptured IA were enrolled. Elderly patients with cerebral infarction (12.4%) had a lower body temperature at admission (p &lt; 0.001), higher prevalence of hypertension and diabetes (p = 0.051 and p = 0.092, respectively), and higher rate of poor outcomes (p &lt; 0.001). Admission body temperature was independently associated with cerebral infarction (odds ratio [OR] = 5.469, p &lt; 0.001); however, hypertension (OR = 0.542, p = 0.056), diabetes (OR = 0.750, p = 0.465), and aneurysm size (OR = 0.959, p = 0.060) showed no association. An inverse correlation between admission body temperature and the incidence of cerebral infarction was observed (Spearman's r =−0.195, p &lt; 0.001). An admission body temperature of 36.6°C was able to distinguish infarction and non-infarction patients. The area under the ROC curve was 0.669 (specificity, 64.15%; sensitivity, 81.50%; p &lt; 0.001).Conclusions: Lower body temperature at admission (≤36.6°C) is an independent predictor of delayed cerebral infarction in elderly patients who have undergone treatment for ruptured IA. Therefore, it could be a risk factor for adverse outcomes of IA.
Nutritional Status and Body Composition in Wilson Disease: A Cross-Sectional Study From China
Authors: Geng Hao , Wang Shijing , Jin Yan , Cheng Nan , Song Bin , Shu Shan , Li Bo , Han Yongsheng , Han Yongzhu , Gao Lishen , Ding Zenghui , Xu Yang , Wang Xun , Ma Zuchang , Sun Yining 
Published: December 2021

Background: Abnormal nutritional status is frequently seen in patients with chronic diseases. To date, no study has investigated the detailed characteristics of abnormal nutritional status among Wilson's disease (WD) patients in the Chinese cohort. This study aimed to describe the nutritional status of WD patients, with a particular focus on the differences between patients with different phenotypes.Methods: The study subjects comprised 119 healthy controls, 129 inpatients (hepatic subtype, n = 34; neurological subtype, n = 95) who were being treated at the affiliated hospital of the Institute of Neurology, Anhui University of Chinese Medicine. All of the subjects were assessed for body composition by using bioelectrical impedance analysis. All WD patients received anthropometry, nutritional risk screening 2002 (NRS2002), and laboratory test (hemocyte and serum biomarkers) additionally.Results: Compared with healthy controls, the fat mass and rate of total body and trunk were significantly higher in WD patients (P &lt; 0.001), the muscle and skeletal muscle mass of total body and trunk were significantly lower in WD patients (P &lt; 0.001). Compared with hepatic subtype patients, the fat mass and rate of total body, trunk, and limbs were significantly lower in neurological subtype patients (P&lt;0.01); while there were no significant differences in muscle and skeletal muscle between these two subtypes. The overall prevalence of abnormal nutritional status in WD patients was 43.41% (56/129). The prevalence of high-nutritional risk and overweight in WD patients was 17.83% (23 of 129) and 25.58% (33 of 129), respectively. Compare with patients with high nutritional risk, macro platelet ratio, alkaline phosphatase, the basal metabolic rate (p &lt; 0.05), creatinine, trunk fat rate (p &lt; 0.01) and appendicular skeletal muscle mass (p &lt; 0.001) were significantly higher in patients without nutritional risk (p &lt; 0.001). Patients with a high nutritional risk tend to have a lower cholinesterase concentration (x2 = 4.227, p &lt; 0.05).Conclusion: Both patients with H-subtype and N-subtype are prone to have an abnormal nutritional status. Longitudinal studies are required to investigate if nutritional status and body composition could reflect prognosis in WD patients, and which of these body composition indexes contribute to malnutrition and worse prognosis.
TECHNOLOGY FORMING ADMINISTRATIVE AND ADMINISTRATIVE CULTURE OF FUTURE OFFICERS OF OPERATIONAL AND TACTICAL LEVEL OF THE NATIONAL GUARANTEE OF UKRAINE
Authors: DENISENKO Ye. 
Published: December 2021

The article defines the main components of the technology of formation of administrative and managerial culture of future officers of the operational-tactical level of NMU in the process of master's training on the basis of the development of the personality of each specialist as a competent, responsible, able to continuously improve the commander with a scientific, professional, administrative and managerial outlook, developed creative practical thinking, able and ready to effectively solve the whole complex of managerial tasks facing him for entity management in various military structures, units and institutions that can build their own management experience in difficult conditions daily activities real circumstances of combat missions. The pedagogical essence and structure of the technology of formation of administrative and managerial culture of future officers of the operational-tactical level in the unity of conceptual, content, operational-methodical, diagnostic components are described. The main feature of the proposed technology for the formation of the administrative and managerial culture of future officers at the operational and tactical level was that instead of a rather fragmented structure of the model of military management with rigid internal rules and the impersonal nature of the relations "commander-subordinate" who demand the conquest of a position, rather than respect for personality It embraces conceptual foundations, content and methods that are oriented towards human resources and are aimed at solving fundamentally new, long- to increase the military-combat effectiveness of the military organization, to maintain its balance with the environment. In this approach, servicemen of the selected category cease to be "cadres"; they are seen as a key factor in success as a resource of officers at the operational-tactical level, with a high level of administrative and managerial culture.
REALIZATION OF THE TUTOR ACCOMPANIMENT IN THE ORGANIZATION OF THE SELF-EMPLOYED WORK OF FOREIGN STUDENTS IN THE HIGHER TECHNICAL EDUCATIONAL INSTITUTION
Authors: DENYSOVETS I. 
Published: December 2021

The article considers and theoretically substantiates the necessity and feasibility of the implementation of tutor support during the organization of independent work of foreign students in the higher technical educational institution. The basic ways of construction and improvement of elements of independent studying of educational material in the context of self-improvement of professional skills of a personality are determined. The main factors influencing the successful performance of independent work by foreign students in technical universities are analyzed. The specific pedagogical means of organization and management of independent activity of foreign students in higher technical educational institutions are studied. The interpretation of the concept of “tutor” in the domestic and foreign pedagogical practice is considered. The content of the tasks of the tutor-teacher, who works directly with foreign students, is analyzed in detail. It is proved that a tutor at a higher technical educational institution creates an educational sphere that allows a foreign student not only to acquire knowledge and skills, but also to solve real problems in his educational activity, to create a comfortable and convenient mode of work for him, especially during the initial stages of adaptation. The author emphasizes that this new method of successful cooperation between the teacher-tutor and foreign citizens who are students of Ukrainian universities is quite optimal and effective in terms of reforming the educational process in higher education, although it requires improvement and some adaptation to the system of higher education in Ukraine.
PREPARATION OF THE FUTURE MANAGER FOR SUCCESSFUL CREATIVE SELF-REALIZATION IN THE INSTITUTION OF HIGHER EDUCATION
Authors: DZEKUN Yu. 
Published: December 2021

The article deals with the directions of the influence of a modern institution of higher education on the personal and professional development of the future manager as a potentially successful personality capable of constructive creative self- organization, analyzing social roles, the implementation of which allows the student to gain experience in constructive self-development. One of the main tasks of the higher school as a person-formation environment is the creation of a broad system of events in which the student would acquire sufficient social and quasi-professional experience, and, it is the experience of successful, that would become the basis for making decisions that are adequate to their own intentions and opportunities, and provided a high level of motivation to expand its own success zone.
V.G. KOROLENKO AGRICULTURAL YOUNG OFFENDERS INSTITUTION : EXPERIENCE OF SAFETY CHILDREN'S EDUCATION IN POLTAVA REGION
Authors: ILCHENKO O. 
Published: December 2021

The problem of homeless children in Ukraine of the 21th century has been updated. The best practices of one of the first managers in the Poltava region, who initiated the re-education of young people on the principles of teamwork and cohesiveness of pupils around joint productive work, were analyzed by Fedor Danilovich Ivanov, the head of the children's agricultural colony named after V.G. Korolenko.The main achievements of the colony were identified: the creation of a system of children's self-governance, the structure that included general meetings, the organizational committee, the system of detachments, commissions (economic, sanitary, linen, club board, library, editorial); availability of Pioneer and Komsomol organization; clear organization of the labor process of the colonists; organization and provision of educational work for pupils; organization of cultural and educational life and improvement of children.The author notes that the organization of work’s level has ensured its high effectiveness: the upbringing and returning to the full life of hundreds of pupils (together with the labor colony of A. S. Makarenko, about 2 thousand pupils were rescued by children's institutions, the cases of relapse were not recorded among them); the recognition of the colony of the People's Commissariat of Ukraine as a research and development institution, 1925; the abandonment of the posts of educators and the transition to self-governing colonial administration, from 1928 (colony named after M. Gorky, since 1930); the popularization of the experience of educational work in pedagogical journals, journals, methodical collections. There was concluded that the efficiency and high results in education had become possible due to the innovative, non- standard approach to work created by the personal convictions and views, efforts and desires of Theodore Danilovich Ivanov, his dedication and love for children. The specifics of work with children of preschool and junior school age have helped the children's institution become an innovative center for the development and validation of democratic, humane views on the education of young people.The author expresses the hope that the innovative experience of upbringing street children of Fyodor Ivanov will not only be a historical value, but will also be a real example for the formation of Ukrainian citizens and their return to full- fledged life.
OPTIMIZATION OF PROFESSIONAL PREPARATION OF FUTURE FACTORS FROM CYBER SECURITY BASED ON INNOVATIVE PEDAGOGICS AND INTEGRATED APPROACH IN THE RELEASATION SYSTEM OF KEY SECURITY COMPETENCES IN INFORMATIONAL SOCIETY
Authors: MELNYK S. , VOSKOBOINIСOV S. 
Published: December 2021

The article substantiates the optimization of the professional training of future cybersecurity specialists on the basis of innovative pedagogy and an integrated approach in the implementation of key security competencies in the information society. It has been determined that the specificity of professional training and the formation of professional competence of future cyber security specialists results in the application of an integrated approach based on interdisciplinary links between professional and fundamental educational disciplines and an effective allocation of training modules in the system of professional training, taking into account modernization educational changes, pedagogical innovation and application innovative educational technologies for the formation of a comprehensive readiness for the implementation of professional competences in cybersecurity.The task of ensuring the cyber security of a person, society, state and the international community is extremely important from the point of view of ensuring public, national and international security, observance of the guarantee of human and civil rights and freedoms in cyberspace.