bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-cell gene expression and chromatin accessibility profiling of human pancreatic islets at basal and stimulatory conditions nominates mechanisms of type 1 diabetes genetic risk
Authors: Albanus Ricardo D’Oliveira , Tang Xuming , Taylor Henry J. , Manickam Nandini , Erdos Michael , Narisu Narisu , Han Yuling , Orchard Peter , Varshney Arushi , Liu Chengyang , Naji Ali ,   HPAP Consortium, Collins Francis S. , Chen Shuibing , Parker Stephen C. J. 
Published: November 2022

AbstractType 1 diabetes (T1D) is a complex autoimmune disease characterized by the loss of pancreatic islet beta cells. The mechanisms of T1D genetic risk remain poorly understood. Here, we present a multi-omic integrative study of single-cell/nucleus molecular profiles of gene expression and chromatin accessibility in the same biological samples from healthy and beta cell autoantibody+(AAB+) human pancreatic islets to characterize mechanisms of islet-mediated T1D genetic risk. We additionally performed single-cell/nucleus multi-omic profiling of healthy islets under two stimulatory conditions used asin vitromodels of T1D (cytokine cocktail and CVB4 infection) to evaluate how environmental exposures recapitulate multi-omic signatures of T1D. In total, we analyzed 121,272 cells/nuclei across 34 libraries, identifying 10 distinct cell types. We identified cell-type-specific and disease-associatedcis-regulatory elements and nominated likely target genes. We provide evidence that T1D genetic risk is mediated through multiple pancreatic cell populations, including islet endocrine cells (beta, alpha, gamma, and delta), exocrine acinar and ductal cells, and immune cells. Finally, we identified three independent T1D risk variants acting through pancreatic islet endocrine cells at theTOX, RASGRP1, andDLK1/MEG3loci. Together, this work improves our understanding of how non-coding genetic variants encode T1D risk through a complex interplay of different cell types in the pancreas.
Rates of Event Capture of Ambulatory Video EEG
Authors: Nurse Ewan S. , Hannon Timothy , Wong Victoria , Fernandes Kiran M. , Cook Mark J. 
Published: November 2022

AbstractObjectivesRecording electrographic and behavioral information during epileptic and other paroxysmal events is important during video EEG monitoring. This study was undertaken to measure the event capture rate of an ambulatory service operating across Australia using a shoulder-worn EEG device and telescopic pole-mounted camera.MethodsNeurologist reports were accessed retrospectively. Studies with confirmed events were identified and assessed for event capture by recording modality, whether events were reported or discovered, and wakefulness.Results6,265 studies were identified, of which 2,788 (44.50%) had events. A total of 15,691 events were captured, of which 77.89% were reported. The EEG-ECG amplifier was active for 99.83% of events. The patient was in view of the camera for 94.90% of events. 84.89% of studies had all events on camera, and 2.65% had zero events on camera (mean=93.66%, median=100.00%). 84.42% of events from wakefulness were reported, compared to 54.27% from sleep.ConclusionEvent capture was similar to previously reported rates from ambulatory studies, with higher capture rates on video. Most patients have all events captured on camera.SignificanceAmbulatory monitoring is capable of high rates of event capture, and the use of wide-angle cameras allows for all events to be captured in the majority of studies.HighlightsA review was undertaken of an Australia-wide ambulatory video-EEG monitoring servicePatients were in view of camera for 94.90% of events, and 84.89% of studies had all events on camera84.42% of events from wakefulness were reported, compared to 54.27% from sleep
Protocol for the PEACH in Asia Study: A Prospective Multinational Multicenter Observational Study on the Epidemiology of Severe Critical Events in Pediatric Anesthesia in Asia
Authors: Obara Soichiro , Bong Choon Looi , Kuratani Norifumi , Ustalar Ozgen Zehra Serpil , Seyedhejazi Mahin , Abbasi Shemila , Rai Ekta , Varghese Elsa , Villa Evangeline K , Batanes Teresita A , Ramlan Andi Ade W , Shariffuddin Ina Ismiarti , Teo Rufinah , Sriswasdi Patcharee , Nhoung Pheakdey , Yuen Vivian , Byon Hyo-Jin , Tan Josephine S K ,   Asian Society of Paediatric Anaesthesiologists (ASPA) research special interest group
Published: November 2022

AbstractBackgroundDespite significant advancements in pediatric anesthesia training and guidelines, the incidence of severe critical events in children undergoing anesthesia in Asia remains under-researched. This knowledge gap is particularly pressing given the rare but life-threatening nature of such complications. While studies from high-income countries report a decline in pediatric anesthesia-related mortality, similar data from developing regions, including Asia, are sparse and suggest higher risks.ObjectiveThe Peri-anesthetic Morbidity in Children in Asia (PEACH in Asia) study aims to provide a comprehensive assessment of the incidence and risk factors associated with severe critical events in pediatric anesthesia across Asia. This multinational, multicenter, prospective observational study seeks to enhance understanding of pediatric anesthesia-related risks and variability in practices within the region.MethodsThe study will enroll children aged birth to 15 years undergoing elective or urgent diagnostic or surgical procedures requiring sedation or general anesthesia, with or without regional analgesia. Data collection will focus on severe critical events occurring during and up to 60 minutes post-anesthesia, including laryngospasm, bronchospasm, pulmonary aspiration, drug errors, anaphylaxis, cardiovascular instability, neurological damage, cardiac arrest, and post-anesthetic stridor. The study will also capture patient demographics, medical history, and procedural details to identify potential risk factors.ResultsThe pilot phase of the PEACH in Asia study, conducted from May to June 2023, included 330 patients from ten institutions across nine countries. Preliminary findings revealed a severe critical event incidence rate of 12.4% [95% CI: 9.2-16.4]. Based on these results, the main study plans to recruit approximately 10,958 children across 15 to 30 Asian countries to achieve robust statistical power and refine risk factor identification.ConclusionThe PEACH in Asia study represents a critical step towards understanding and mitigating the risks associated with pediatric anesthesia in Asia. By providing data-driven insights into the incidence of severe critical events and regional variations in anesthesia practices, this study aims to inform and improve pediatric anesthesia protocols across the continent.
Off-Vertical Body Orientation Delays the Perceived Onset of Visual Motion
Authors: Chung William , Barnett-Cowan Michael 
Published: November 2022

SummaryThe integration of vestibular, visual and body cues is a fundamental process in the perception of self-motion and is commonly experienced in an upright posture. However, when the body is tilted in an off-vertical orientation these signals are no longer aligned relative to the influence of gravity. In this study, sensory conflict with the vestibular signal was introduced by manipulating the orientation of the body, generating a mismatch between body and vestibular cues due to gravity in the perception of upright and creating an ambiguous vestibular signal of either head tilt or translation. In a series of temporal-order judgment tasks, participants reported the perceived onset of a visual scene simulating rotation around the yaw axis presented in virtual reality with a paired auditory tone while in an upright, supine and side recumbent body positions. The results revealed that the perceived onset of visual motion was further delayed from zero (i.e., true simultaneity between visual onset and a reference auditory tone) by approximately an additional 30ms when viewed in a supine or side recumbent orientation compared to an upright posture. There were also no significant differences in the timing estimates of the visual motion between all the non-upright orientations. This indicates that the perceived timing of visual motion is negatively impacted by the presence of conflict in the vestibular and body signals due to the direction of gravity and body orientation, even when the mismatch is not in the direct plane of the axis of rotation.
CHK1-CDC25A-CDK1 regulate cell cycle progression in early mouse embryos to protect genome integrity
Authors: Lucie Knoblochova , Tomas Duricek , Michaela Vaskovicova , Chrysoula Zorzompokou , Diana Rayova , Ivana Ferencova , Vladimir Baran , Schultz Richard M. , Hoffmann Eva R. , David Drutovic 
Published: November 2022

ABSTRACTAfter fertilization, remodeling of the oocyte and sperm genomes is essential to convert these highly differentiated non-dividing transcriptionally quiescent cells into early cleavage-stage transcriptionally active totipotent blastomeres. This developmental transition is accompanied by cell cycle adaptation such as lengthening or shortening of the gap phases G1 and G2. However, regulation of these cell cycle changes is poorly understood, especially in mammals. Checkpoint kinase 1 (CHK1) is a protein kinase that regulates cell cycle progression in somatic cells. Here, we show that CHK1 regulates cell cycle progression in early mouse embryos by restraining CDK1 kinase activity due to CDC25A phosphatase degradation. CHK1 kinase also ensures the long G2 phase needed for genome activation and reprogramming gene expression in 2-cell stage mouse embryos. Last,Chk1depletion leads to DNA damage and chromosome segregation errors that result in aneuploidy and infertility.
Clinical care of patients with dual disorders in India: diverse models of care delivery
Authors: Balhara Yatan Pal Singh , Ghosh Abhishek , Sarkar Siddharth , Mahadevan Jayant , Pal Arghya , Narasimha Venkata Lakshmi , Kattula Dheeraj , Prasad Sambhu , Parmar Arpit , Kathiresan Preethy , Basu Anirudha , Bhatia Gayatri , Shah Raghav , Dhagudu Naveen Kumar , Tripathi Richa , Bharadwaj Balaji 
Published: November 2022

Purpose
This study aims to offer an overview of the models of clinical care of the patients with dual disorders in India.

Design/methodology/approach
All the members of the Dual Diagnosis India Network (DDIN) who shared the clinical care delivery at their center were invited to share the details of their model. In addition, an invite was also sent to those members who could not attend the online session but were interested in contributing the required information about their model. The information shared by the respondents was collated. The different models were then categorized based on their features.

Findings
Following the categorization of the clinical care services organization across different settings, five different models emerged. These were specialized dual diagnosis clinic; services for dual disorders offered as substance use disorder (SUD) treatment services within general psychiatry care; services for dual disorders in general psychiatry care; services for dual disorders offered as SUD treatment services separated from general psychiatry care; and services for dual disorders offered in general psychiatry services combined with exclusive SUD treatment services.

Originality/value
Currently, there is limited literature on models of dual disorders from the low- and middle-income countries. The authors believe that the documentation of these models from India shall be of help while setting up services for dual disorders in other health-care settings. This study can be a valuable resource for making informed choices while setting up new services.
Entrepreneurship as a multidisciplinary phenomenon: culture and individual perceptions in business creation
Authors: Martínez-Martínez Sofía Louise 
Published: November 2022

PurposeEntrepreneurship is presented as a vehicle for innovation and social development. Given the importance of entrepreneurship, the objective of this study was to analyze the psychological and sociological dimensions by determining the factors that explain individual perceptions and cultural support for entrepreneurship.Design/methodology/approachUsing Global Entrepreneurship Monitor (GEM) data obtained from the Adult Population Survey (APS) (N = 2,500) in the region of Andalusia (Spain), a quantitative analysis was carried out, specifically a multivariate analysis based on four-stage linear regressions.FindingsThe variables examined do not explain the psychological and sociological dimensions to the same extent. The results highlight the existence of cultural homogeneity between provinces, the importance of sociodemographic variables and the influence of the entrepreneurial expectations and experiences of the population, especially in shaping individual perceptions towards entrepreneurship.Research limitations/implicationsThe replication of the study at the national and international levels is proposed in order to delve deeper into the cultural differences that condition entrepreneurship. Including new variables associated with entrepreneurial human capital could also be of interest.Practical implicationsThe results can help to improve the design and implementation of policies and programs aimed at fostering entrepreneurship through the promotion of favorable individual perceptions and entrepreneurial culture.Originality/valueThe originality of this study is the consideration of individual perceptions and cultural support for entrepreneurship as dependent variables, since they are normally incorporated as explanatory factors. The results contribute to the advancement of knowledge of the entrepreneurial phenomenon through two approaches, psychological and sociological.
Determinants factors of the performance of metallurgical companies in Northern Portugal: new evidence using panel data
Authors: Neves Maria Elisabete , Castanheira Paulo , Dias António , Silva Rui , Cancela Beatriz 
Published: November 2022

PurposeThe main goal of this paper is to study the specific characteristics of the performance of companies in the metallurgical sector, in the northern region of Portugal.Design/methodology/approachTo achieve this aim, the authors have used data from 325 companies manufacturing metal products, except machinery and equipment (CAE Rev.3 25) and 27 companies that manufacture machinery and equipment (CAE Rev. 3 28). The models were estimated by using the panel data methodology for the period between 2011 and 2019. Specifically, the estimation method of the generalized method of moments system (GMM system) proposed by Arellano and Bover (1995) and Blundell and Bond (1998) was used.FindingsThe results show that the main decisions on the performance of metallurgical companies in Northern Portugal depend on the dimensions of sales in the domestic market (SDM), sales in the community market (SCM), and sales in the foreign market (SFM) and also highlight that the signal and significance of the specific variables depends on how the different stakeholders understand performance.Originality/valueAs far as the authors know, this is the first study to comparatively analyze the two metallurgical databases in Portugal. Despite the huge difference in the size of the sample, this study’s results show that in an era of paradigm shift about what business objectives should be, stakeholders are still not environmentally aware and the social dimension is only considered by shareholders, but not yet by the manager and the general community.
Hospitality order cancellation prediction from a profit-driven perspective
Authors: Liu Zhenkun , Jiang Ping , Wang Jianzhou , Du Zhiyuan , Niu Xinsong , Zhang Lifang 
Published: November 2022

Purpose
This study/paper aims to reach the core objective of hospitality order cancellation prediction (HOCP), that is, to identify potential cancellers from many customer bases, thereby enhancing the effectiveness of customer retention campaigns. However, few studies have focused on predicting hospitality order cancellation.

Design/methodology/approach
A novel profit-driven model for predicting hospitality order cancellation is proposed to bridge this research gap. The authors construct profit-driven extreme gradient boosting (XGBoost) based on a grid search on HOCP to maximize profit by selecting optimal hyperparameters of XGBoost.

Findings
Real-world data set is analyzed, and the proposed model yields more profits than other predictive models. Sensitivity analysis proves that the proposed model is robust to the key hyperparameter and application scenario. Furthermore, some preventive measures based on visual analysis results are provided to reduce the cancelled probability of orders.

Research limitations/implications
This research will help hotel managers to transfer the modeling goal to profit orientation and encourage relevant researchers to interpret the prediction results of models for hotel order cancellation prediction in a post hoc manner. Besides, the proposed model can be applied to various enterprises with different average order profits and help managers optimize revenue management.

Originality/value
This research expands the relevant literature and offers guidance for predicting hospitality order cancellation from a profit-driven perspective at the customer level. The proposed model can provide macro-control to hotel managers and obtain the most satisfactory profits in micro-control.
Leveraging supply chain disruption orientation for resilience: the roles of supply chain risk management practices and analytics capability
Authors: Liu Hua , Wei Shaobo 
Published: November 2022

PurposeBuilding on the information processing perspective, the authors propose that both internal and external supply chain risk management (SCRM) practices play essential roles in mediating supply chain disruption orientation (SCDO) to exercise an influence on resilience. The authors also put forward analytics capability as an important moderator in the above-mediated relationship.Design/methodology/approachThe authors collected 170 match-paired questionnaires from Chinese firms to test our model. The authors further interviewed some managers to supplement key quantitative results.FindingsFirst, SCDO positively affects resilience via internal and external SCRM practices. Second, the mediating effects of internal and external SCRM practices are stronger when analytics capability is higher. Third, analytics capability positively moderates the positive effect of SCDO on SCRM practices. Meanwhile, it does not moderate the positive effect of SCRM practices on resilience.Research limitations/implicationsOur study contributes to SCRM-related and IT-related literature by considering the content, mediating mechanisms (i.e. internal and external SCRM practices) and boundary conditions (i.e. data analytic capability) of SCDO in shaping resilience in the digital supply chain.Practical implicationsOur study helps remind managers that firms build disruption orientation, develop different SCRM practices and leverage analytics capability to improve resilience amid unexpected and unplanned disruptions.Originality/valueOur study sheds light on the roles of both internal and external SCRM practices. Furthermore, this research helps explain how SCDO motivates resilience through SCRM practices, particularly for those firms that have higher analytics capability.
Performance implications of the interaction between the accountants’ participation in strategic decision-making and accounting capacity
Authors: Bui Hung Quang , Hoai Tu Thanh , Tran Hoa Anh , Nguyen Nguyen Phong 
Published: November 2022

PurposeBased on the contingency theory and resource-based view, this study develops and tests a moderated mediation model explaining the performance implications of the interaction between the accountants’ participation in strategic decision-making (APAR) and accounting capacity (ACAP) in promoting the use of management accounting systems (MAS) toward enhancing firm performance.Design/methodology/approachUsing partial least squares structural equation modeling, the authors tested the proposed model and its hypotheses with survey data from 340 large Vietnamese firms.FindingsThe results indicate that (1) MAS act as the full mediator in the positive relationship between APAR and firm performance, and (2) ACAP positively moderates the effect of APAR on the use of MAS.Originality/valueThis study bridges the gap between accounting and strategic management literature by elucidating the mechanism by which the involvement of accountants in strategic issues improves the use of MAS toward enhancing firm performance and increases the current understanding of ACAP as a boundary condition for this mechanism.
Impact of government responses to COVID-19 on the resilience of FDI attractiveness factors in the Asian region
Authors: Kammoun Souhaila , Ben Romdhane Youssra 
Published: November 2022

PurposeThe purpose of this paper is twofold. Firstly, the paper aims to determine the separate effects of the COVID-19 pandemic and government actions represented by the index of stringency, containment and economic support on the attractiveness of foreign direct investment (FDI). Secondly, the paper aims to explore the impact of the interactions between the COVID-19 epidemic and government interventions on FDI.Design/methodology/approachThe study uses a panel data set of 30 Asian countries during the two pandemic years 2020 and 2021 to investigate the effect of government actions on the resilience of FDI attractiveness factors.FindingsThe empirical results reveal the negative effect of COVID-19 on FDI inflows and attractiveness factors. However, government responses have a positive and statistically significant effect on the FDI attractiveness factors such as economic growth, trade openness and human and technological capital development and contribute to the economic recovery of the Asian region.Practical implicationsThe empirical findings can provide useful information for policymakers in designing macroeconomic policies and taking government measures to improve their investment environment and attract FDI.Originality/valueThe study shows that government responses, economic support, containment and health policies are effective in containing viruses, reducing the impact of the COVID-19 pandemic and strengthening resilience in FDI attractiveness factors. It also indicates that foreign investors are responding positively to government measures.