bluuebunny/crossref_metadata_2025_split huggingface dataset:
A preliminary evaluation of Kids Matter: A community‐based parenting intervention
Authors: Esteban‐Serna Celia , Eisenstadt Mia , Gardner Eli , Liverpool Shaun 
Published: July 2022

AbstractParents living in deprived communities are more likely to report lower parental self‐efficacy and wellbeing. Poor parental wellbeing and self‐efficacy are known risk factors in the development of a range of health and behavioural problems in childhood, adolescence and adulthood. Parenting interventions are key to prevent adverse outcomes in children, however, the mechanisms by which parents learn to understand and support their children are still not well understood. This study evaluated the acceptability of Kids Matter, a parenting intervention targeting parents who are struggling with financial adversity. Secondarily, the relationship between parental wellbeing and and self‐efficacy was examined. The present is a retrospective, consecutive case series design study, comparing routinely collected data at pre‐intervention, post‐intervention, and at 3‐month follow‐up. Descriptive frequencies were drawn to explore parents' impressions of the programme. Multivariate analysis of variance and regression modelling were used to evaluate associations between parental wellbeing and self‐efficacy at different time points. Parents found the programme enjoyable and useful. The intervention led to significant improvements in parental wellbeing and self‐efficacy. Improvements in parental wellbeing were significantly associated with improvements in self‐efficacy. This study provides evidence of the acceptability and effectiveness of Kids Matter.
Randomized phase III study of gemcitabine, cisplatin plus S‐1 versus gemcitabine, cisplatin for advanced biliary tract cancer (KHBO1401‐ MITSUBA)
Authors: Ioka Tatsuya , Kanai Masashi , Kobayashi Shogo , Sakai Daisuke , Eguchi Hidetoshi , Baba Hideo , Seo Satoru , Taketomi Akinobu , Takayama Tadatoshi , Yamaue Hiroki , Takahashi Masahiro , Sho Masayuki , Kamei Keiko , Fujimoto Jiro , Toyoda Masanori , Shimizu Junzo , Goto Takuma , Shindo Yoshitaro , Yoshimura Kenichi , Hatano Etsuro , Nagano Hiroaki ,   Kansai Hepatobiliary Oncology Group (KHBO)
Published: July 2022

AbstractBackgroundGemcitabine/cisplatin (GC) combination therapy has been the standard palliative chemotherapy for patients with advanced biliary tract cancer (BTC). No randomized clinical trials have been able to demonstrate the survival benefit over GC during the past decade. In our previous phase II trial, adding S‐1 to GC (GCS) showed promising efficacy and we aimed to determine whether GCS could improve overall survival compared with GC for patients with advanced BTC.MethodsWe performed a mulitcenter, randomized phase III trial across 39 centers. Enrolled patients were randomly allocated (1:1) to either the GCS or GC arm. The GCS regimen comprised gemcitabine (1000 mg/m2) and cisplatin (25 mg/m2) infusion on day 1 and 80 mg/m2 of S‐1 on days 1–7 every 2 weeks. The primary endpoint was overall survival (OS) and the secondary endpoints were progression‐free survival (PFS), response rate (RR), and adverse events (AEs). This study is registered with Clinical trial identification: NCT02182778.ResultsBetween July 2014 and February 2016, 246 patients were enrolled. The median OS and 1‐year OS rate were 13.5 months and 59.4% in the GCS arm and 12.6 months and 53.7% in the GC arm, respectively (hazard ratio [HR] 0.79, 90% confidence interval [CI]: 0.628–0.996; P = .046 [stratified log‐rank test]). Median PFS was 7.4 months in the GCS arm and 5.5 months in the GC arm (HR 0.75, 95% CI: 0.577–0.970; P = .015). RR was 41.5% in the GCS arm and 15.0% in the GC arm. Grade 3 or worse AEs did not show significant differences between the two arms.ConclusionsGCS is the first regimen which demonstrated survival benefits as well as higher RR over GC in a randomized phase III trial and could be the new first‐line standard chemotherapy for advanced BTC. To exploit the advantage of its high RR, GCS is now tested in the neoadjuvant setting in a randomized phase III trial for potentially resectable BTC.
The extracellular sialidase NEU3 primes neutrophils
Authors: Kirolos Sara A , Pilling Darrell , Gomer Richard H 
Published: July 2022

AbstractSome extracellular glycoconjugates have sialic acid as the terminal sugar, and sialidases are enzymes that remove this sugar. Mammals have 4 sialidases and can be elevated in inflammation and fibrosis. In this report, we show that incubation of human neutrophils with the extracellular human sialidase NEU3, but not NEU1, NEU2 or NEU4, induces human male and female neutrophils to change from a round to a more amoeboid morphology, causes the primed human neutrophil markers CD11b, CD18, and CD66a to localize to the cell cortex, and decreases the localization of the unprimed human neutrophil markers CD43 and CD62-L at the cell cortex. NEU3, but not the other 3 sialidases, also causes human male and female neutrophils to increase their F-actin content. Human neutrophils treated with NEU3 show a decrease in cortical levels of Sambucus nigra lectin staining and an increase in cortical levels of peanut agglutinin staining, indicating a NEU3-induced desialylation. The inhibition of NEU3 by the NEU3 inhibitor 2-acetylpyridine attenuated the NEU3 effect on neutrophil morphology, indicating that the effect of NEU3 is dependent on its enzymatic activity. Together, these results indicate that NEU3 can prime human male and female neutrophils, and that NEU3 is a potential regulator of inflammation.
Linking regional sustainable development goals with ecosystem services to identify ecological security patterns
Authors: Lyu Xin , Li Xiaobing , Wang Kai , Cao Wanyu , Gong Jirui , Wang Hong , Lou Anru 
Published: July 2022

AbstractEcological security patterns (ESPs) have become an important spatial approach to alleviate the contradiction between ecological protection and economic development. The identification of ecological sources is the primary part of studying ESPs, and methods based on ecosystem services (ESs) have been widely used. However, the current method of simply overlaying ESs for ecological source identification has difficulty supporting different regional decision‐making needs of the target. Taking the West Liaohe River basin in China as an example, this study aims at developing four regional sustainable development goals (RSDGs) of carbon neutrality, water security, soil security, and biodiversity protection. Six ESs, including net primary production (NPP), water retention (WR), water purification (WP), soil conservation (SC), soil loss by wind (SL), and habitat quality (HQ), in the West Liaohe River basin from 2010 to 2020 were evaluated. Based on the current mainstream research paradigm of ‘source identification‐resistance surface construction‐corridor extraction‐safety pattern identification’, combined RSDGs and ESs, the minimum cumulative resistance (MCR) model was used to identify the West Liaohe River basin development goals. The pattern of ecological security was discussed, and the identification, optimization, and construction plan of the regional comprehensive ESP were discussed in combination with the actual situation of the region. The study found that simply overlaying ESs to identify ecological sources leads to the neglect of some areas that provide key ESs, and it is difficult to directly support regional ecological protection decisions under different objectives, while a multiobjective‐oriented comprehensive ecological security pattern helps to promote ESs and their relationships. The research results will help to improve the understanding of the ESP and provide a basis for the ecological protection and restoration of the basin and the optimization of the spatial structure to promote the sustainable development of the ‘social‐economic‐ecological’ complex system in the West Liaohe River basin.
Buying happiness: How brand engagement in self‐concept affects purchase happiness
Authors: Razmus Wiktor , Grabner‐Kräuter Sonja , Kostyra Martyna , Zawadzka Anna Maria 
Published: July 2022

AbstractIn general, experiential purchases have been found to make people happier than material purchases. However, previous research has ignored a crucial issue—the importance of the brand and the consumer−brand relationship in this context. Since many purchases are associated with a brand and the brand is often the main motivation for the purchase, we argue that researchers should include the consumer−brand relationship in studies on the effects of material versus experiential consumption on happiness. Building on the social exchange theory, the current research examines the moderating role of consumers' tendency to include brands as part of the self in the relationship between purchase type and happiness. Across three studies, using different methods (a comparative survey: N1 = 422 individuals; two experiments: N2 = 206 and N3 = 177 individuals), we found that individuals with high levels of brand engagement in self‐concept (BESC) derive similar levels of purchase‐related happiness from experiential and material purchases, while individuals with low levels of BESC find more purchase‐related happiness in experiential than in material purchases.
Impact of climate change on hospital admissions: a case study of the Royal Berkshire Hospital in the UK
Authors: Israelsson Jennifer , Charlton‐Perez Andrew , Sun Ting 
Published: July 2022

AbstractGlobal warming is projected to have major implications on global health. It is however not yet clear how this will translate to impacts on the healthcare system. By linking changes in temperature with changes in required bed days at a hospital level, through the use of a simple bed model, we quantify the projected impacts UK hospitals will need to adapt to. We show that there is already a local peak of bed days required in the main summer months due to hot temperatures. The results further show that there will be a significant increase during the main summer in both the mean and maximum number of beds needed, but a non‐significant decrease during the peak winter months. These changes lead to a more constant need of care of the year and shift the seasonal cycle of lowest hospital needs.
A three‐state diplexer design using stub‐loaded resonator pairs
Authors: Zhang Yao , Lin Xian‐Jing , Gu Wei‐Dong 
Published: July 2022

AbstractThis letter presents a three‐state diplexer design. By employing one port as the input while the other two as the output, the proposed circuit functions as three diplexers operating at different passbands. Owing to the planar stub‐loaded resonator pair, two transmission zeros are generated at passband edges, ensuring sharp frequency selectivity for each filter passband. In addition, an asymmetrical feed scheme is adopted based on the discriminating coupling method, resulting in two other controllable out‐of‐band transmission zeros. These zeros are essential for isolation improvement between the three diplexer operations. For demonstration, the three‐state diplexer is implemented. Compact size and measured isolation of more than 27.6 dB between the three states are obtained.
Efficacy of a Short-Term Captive Broodstock Program Compared with Hatchery-Origin Spring Chinook Salmon Derived from the Same Population
Authors: Gallinat Michael P. , Bumgarner Joseph D. , Ross Lance A. 
Published: July 2022

Abstract
We examined the efficacy of a one-generation (five brood years: 1997–2001) captive broodstock program for spring Chinook Salmon Oncorhynchus tshawytscha by comparing survival rates of captive broodstock progeny (CBP; F2) with that of hatchery-origin fish (HOR) from a conservation hatchery supplementation program in which both groups were derived from the Tucannon River (Washington State) population for the 2000–2006 brood years. Survival rates compared were egg to fry, fry to smolt, egg to smolt, total (ages 3–5) and adult (ages 4+) smolt-to-adult-return (SAR) survival, and total (ages 3–5) and adult (ages 4+) progeny-to-parent (P:P) ratio. Total escapement and adult P:P ratios were also examined to determine if observed demographic benefits to the population continued after the captive broodstock program ended. The CBP group had lower within-hatchery survival than the HOR group, with significant differences in survival at the egg-to-fry and egg-to-smolt stages due to poor egg viability. Mean untransformed total and adult SARs for the CBP were half those of the HOR group; however, SARs did not differ significantly. The CBP also had significantly lower total and adult P:P ratios than the HOR group and were below replacement for six of the seven brood years. While the captive broodstock provided additional fish for release that would not have been available otherwise, overall the CBP performed poorly and below expectations compared with the HOR group, both within the hatchery and after release. The captive broodstock program provided a short-term demographic boost, most notable in the 2008–2010 return years, but the benefit did not carry over after the program ended.
Mixing Oil and Water: The Shrimp–Petroleum Nexus in Coastal Louisiana
Authors: Davidov Veronica 
Published: July 2022

AbstractThe Shrimp‐Petroleum Festival is an annual event in Morgan City, Louisiana, that celebrates the history of the two industries in this coastal city. The festival came under media scrutiny and public criticism in the wake of the 2010 BP oil spill in the Gulf of Mexico, in part because of the seeming incompatibility and incongruence of the two things being celebrated. From a local perspective, however, the convergence of the two industries is far from incompatible and the two resources in question, shrimp and oil, are categorically similar within local discourses of identity, well‐being, and economic prosperity. In that capacity, it offers an insight into how precarious and contingent the seemingly self‐evident dichotomies commonly invoked in normative environmentalism are. It also offers insight and into the range of assumptions and signification practices involved in assigning meaning to particular kinds of resources and particular kinds of human–nature relations.
The association between premenstrual syndrome before pregnancy and antenatal depression: A cross‐sectional study with prerecorded information
Authors: Hidaka Yui , Kawakami Norito , Watanabe Kazuhiro , Nishi Daisuke 
Published: July 2022

AbstractAimSome studies have examined the relationship between premenstrual syndrome (PMS) and antenatal depression. However, retrospective designs were used to obtain the PMS experiences. Different from such earlier research, this study aims to investigate the association between PMS before pregnancy and antenatal depression with a prospective design.MethodThis is a secondary analysis of a randomized controlled trial (RCT) conducted among pregnant women. Premenstrual symptoms before pregnancy of the participants were obtained prospectively via a period tracking app. At the baseline of the RCT, 5073 women participated. Of those, 3004 had one or more symptom records related to menstruation 1 year before pregnancy. The outcome, antenatal depression, was assessed using the Edinburgh Postnatal Depression Scale (EPDS) at the RCT baseline, and the cut‐off value was set at 11. For covariates, age, education, planned pregnancy, and the number of children were also measured at the same time. Multiple logistic regression analyses were employed to estimate the odds ratio (OR) of having antenatal depression, adjusting for the covariates.ResultsA total of 366 individuals who had three or more cycles of menstrual‐related symptom records were included in the analyses, and of those 52 were applicable to PMS before pregnancy. There was no significant association between PMS and antenatal depression (adjusted OR = 1.28, P = 0.61).ConclusionThe present study was the first study to utilize a prospective design to obtain premenstrual symptoms. Future research should consider using a validated and objective measure of PMS diagnosis and a larger sample.
Plasma polymer barrier layers to control the release kinetics from dissolvable microneedle patches
Authors: González García Laura E. , MacGregor Melanie , Cavallaro Alex , Koynov Kaloian , Vasilev Krasimir 
Published: July 2022

AbstractDissolving microneedles are a noninvasive transdermal drug delivery platform that offers painless needle‐free patient treatment. Current strategies to control the kinetics of drug release from the polymeric microneedle patches consist of adjusting the bulk polymer formulations and/or encapsulating the cargo in controlled delivery vehicles. Instead, in this study, the drug release rates were altered by modifying the surface properties of the microneedles using plasma polymer coatings with tailored properties. The main advantage of this one‐step, solvent‐free, and scalable method is that it can be applied to any type of microneedles regardless of their drug cargo or bulk material. Octadiene plasma polymer films were found to suppress the burst release effect of otherwise rapidly dissolving microneedles and to reduce the dissolution rate by a factor of four compared to uncoated control patches. The approach presented in this study offers an alternative, highly tunable, and customizable strategy for controlling drug release rate from microneedle patches.
Diarylprolinol as an Effective Organocatalyst in Asymmetric Cross‐Aldol Reactions of Two Different Aldehydes
Authors: Hayashi Yujiro 
Published: July 2022

AbstractThe aldol reaction is one of the most important carbon‐carbon bond‐forming reactions in organic chemistry. Asymmetric direct cross‐aldol reaction of two different aldehydes has been regarded as a difficult reaction because of the side reactions such as self‐aldol reaction and over reaction. We found that trifluoromethyl‐substituted diarylprolinol, α,α‐bis[3,5‐bis(trifluoromethyl)phenyl]‐2‐pyrrolidinemethanol (1), is an effective organocatalyst that promotes several cross‐aldol reactions of aldehydes with excellent diastereo‐ and enantioselectivities. Acetaldehyde can be employed as a suitable nucleophilic aldehyde. Successful electrophilic aldehydes are ethyl glyoxylate, chloroacetaldehyde, dichloroacetaldehyde, chloral, α‐alkyl‐α‐oxo aldehyde, trifluoroacetaldehyde, glyoxal, alkenyl aldehyde, alkynyl aldehyde, and formaldehyde. Some of the aldehydes are commercially available as a polymer solution, an aqueous solution, or in the hydrated form. They can be used directly in the asymmetric aldol reaction as a commercially available form, which is a synthetic advantage. Given that the obtained aldol products possess several functional groups along with a formyl moiety, they are synthetically useful chiral building blocks.
Next-to-leading power endpoint factorization and resummation for off-diagonal “gluon” thrust
Authors: Beneke M. , Garny M. , Jaskiewicz S. , Strohm J. , Szafron R. , Vernazza L. , Wang J. 
Published: July 2022

Abstract
The lack of convergence of the convolution integrals appearing in next-to-leading-power (NLP) factorization theorems prevents the applications of existing methods to resum power-suppressed large logarithmic corrections in collider physics. We consider thrust distribution in the two-jet region for the flavour-nonsinglet off-diagonal contribution, where a gluon-initiated jet recoils against a quark-antiquark pair, which is power-suppressed. With the help of operatorial endpoint factorization conditions, we obtain a factorization formula, where the individual terms are free from endpoint divergences in convolutions and can be expressed in terms of renormalized hard, soft and collinear functions in four dimensions. This allows us to perform the first resummation of the endpoint-divergent SCETI observables at the leading logarithmic accuracy using exclusively renormalization-group methods. The presented approach relies on universal properties of the soft and collinear limits and may serve as a paradigm for the systematic NLP resummation for other 1 → 2 and 2 → 1 collider physics processes.
A stationary shoulder with fluid temperature control for friction stir welding of polymers: development and investigation
Authors: Buchmann Erhard , Erdmann Michael , Köberl Mathias , Höfer Philipp 
Published: July 2022

AbstractThere is a growing interest in the application of thermoplastics and thermoplastic composites for lightweight structures, thus also in friction stir welding (FSW) as a suitable joining technology. With the transformation of FSW from metals to polymers, several new tooling concepts were developed; mainly various heating setups to add external thermal energy to the process were designed. However, current temperature control approaches do not consider the cooling of the process at high rotational speeds and the asymmetry of the process in thermomechanical conditions. In this paper, we present a stationary shoulder with fluid temperature control, which is also capable of cooling the process. Additionally, asymmetric temperature control conditions can be examined by applying different flow directions. For investigation, butt welds of PMMA sheets were welded and assessed using the weld morphology and tensile strengths. Different fluid temperatures, feed rates, and both flow directions were applied and led to different tensile strengths. It could be shown that the optimal control temperature is different for the advancing side (AS) and the retreating side (RS). By using a transverse flow, a heat transport from the warmer AS to the colder RS could be established, which improved the strength. Moreover, the tensile strength could be increased by cooling the process at a feed rate of 100 mm/min. To improve the effectiveness of the temperature control, a new shoulder with independent temperature-controlled areas is proposed.
Powering single-cell genomics to unravel circulating tumour cell subpopulations in non-small cell lung cancer patients
Authors: Acheampong Emmanuel , Morici Michael , Abed Afaf , Bowyer Samantha , Asante Du-Bois , Lin Weitao , Millward Michael , Gray Elin S. , Beasley Aaron B. 
Published: July 2022

AbstractBackgroundCirculating tumour cells (CTCs) are attractive “liquid biopsy” candidates that could provide insights into the different phenotypes of tumours present within a patient. The epithelial-to-mesenchymal transition (EMT) of CTCs is considered a critical step in tumour metastasis; however, it may confound traditional epithelial feature-based CTC isolation and detection. We applied single-cell copy number alteration (CNA) analysis for the identification of genomic alterations to confirm the neoplastic nature of circulating cells with only mesenchymal phenotypes.MethodsWe isolated CTCs from blood samples collected from 46 NSCLC patients using the Parsortix system. Enriched cells were subjected to immunofluorescent staining for CTC identification using a multi-marker panel comprising both epithelial and mesenchymal markers. A subset of isolated CTCs was subjected to whole genome amplification (WGA) and low-pass whole-genome sequencing (LP-WGS) for the analysis of copy number alterations (CNAs).ResultsCTCs were detected in 16/46 (34.8%) patients, inclusive of CK+/EpCAM+CTCs (3/46, 6.5%) and Vim+CTCs (13/46, 28.3%). Clusters of Vim+cells were detected in 8 samples, which constitutes 50% of the total number of NSCLC patients with CTCs. No patients had detectable hybrid CK+/EpCAM+/Vim+cells. All of the tested CK+/EpCAM+CTCs and 7/8 Vim+CTCs or CTC clusters carried CNAs confirming their neoplastic nature. Notably, the Vim+cluster with no CNAs was characterised by spindle morphology and, therefore, defined as normal mesenchymal circulating cells.ConclusionOur results revealed that CK-negative, vimentin-expressing cells represent a large proportion of CTCs detected in NSCLC patients, which are likely missed by standard epithelial-marker-dependent CTC categorisation.