bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative study of the ability of recombinant oncolytic adenovirus, doxorubicin and tamoxifen to inhibit the proliferation of breast cancer cells
Authors: Li Shanzhi , Li Zhuoxin , Li Yiquan , Zhu Yilong , Han Jicheng , Li Wenjie , Jin Ningyi , Fang Jinbo , Li Xiao , Zhu Guangze 
Published: September 2022

AbstractIn this study, we compared the inhibitory effects of recombinant oncolytic adenovirus (Ad‐apoptin‐hTERTp‐E1a, Ad‐VT) with that of doxorubicin (DOX), a first‐line chemotherapy drug, and tamoxifen (TAM), an endocrine therapy drug, on the proliferation of breast cancer cells. We found that Ad‐VT could effectively inhibit the proliferation of breast cancer cells (p < 0.01); the inhibition rate of Ad‐VT on normal mammary epithelial MCF‐10A cells was less than 20%. DOX can effectively inhibit the proliferation of breast cancer cells and also has a strong inhibitory effect on MCF‐10A cells (p < 0.01). TAM also has a strong inhibitory effect on breast cancer cells, among which the oestrogen‐dependent MCF‐7 cell inhibition was stronger (p < 0.01), At higher concentrations, TAM also had a high rate of inhibition (>70%) on the proliferation of MCF‐10A cells. We also found that both recombinant adenovirus and both drugs could successfully induce tumour cell apoptosis. Further Western blot results showed that the recombinant adenovirus killed breast cancer cells through the endogenous apoptotic pathway. Analysis of the nude mouse subcutaneous breast cancer model showed that Ad‐VT significantly inhibited tumour growth (the luminescence rate of cancer cells was reduced by more than 90%) and improved the survival rate of tumour‐bearing mice (p < 0.01). Compared with DOX and TAM, Ad‐VT has a significant inhibitory effect on breast cancer cells, but almost no inhibitory effect on normal breast epithelial cells, and this inhibitory effect is mainly through the endogenous apoptotic pathway. These results indicate that Ad‐VT has significant potential as a drug for the treatment of breast cancer.
The influence of sodium alginate and sodium alginate/WPI as coating material on microcapsules of Jujube extract produced by spray dryer
Authors: Khoshdouni Farahani Zahra , Mousavi Mohamad , Seyedain Ardebili Mahdi , Bakhoda Hossein 
Published: September 2022

AbstractThe aim of the research was to study the impact of various carrier types (sodium alginate and blend of sodium alginate with WPI) on the physicochemical, structural, and thermal characteristics of Jujube extract powder fabricated by spray drying. TPC and antioxidant activity, solubility, moisture, EE, powder yield, DSC, particle size, and morphology of powders were surveyed. The use of WPI resulted in powders with less moisture (10%), lower solubility (98.04%), and better powder yield (22.50%). WPI‐produced powders showed the best retention of polyphenolic compounds (2949.2 mg/L) and the highest activity of the encapsulation efficiency (70.93%), and moreover, they had a higher Tg (68.50°C), indicating powders that were more stable during storage. All samples showed a large number of spherical particles along with a number of indented particles, and these indentations were more common in protein capsules. In terms of particle diameter, the particles produced with alginate were smaller (6.51 μm). It can be stated that the particles containing proteins can have more effective and efficient outcomes.Novelty impact statementBoth sodium alginate and sodium alginate/WPI powders were loaded with jujube extract (JE) by spray dryer. The encapsulation efficiency of jujube extract in sodium alginate/WPI powders was more. Incorporation of WPI to sodium alginate increased yield, moisture, solubility, and TPC and preserved jujube extract effectively.
Water sorption isotherms of different sodium alginates: Thermodynamic evaluation and influence of mannuronate‐guluronate copolymers
Authors: Montes Leticia , Gisbert Mauro , Moreira Ramón 
Published: September 2022

AbstractWater desorption isotherms of three alginates with different structural features were determined at 25, 37, and 50°C. The Halsey model was selected to fit the equilibrium water sorption data. Differential and integral enthalpy and entropy were estimated for tested alginates. Optimal storage conditions of tested alginates (moisture content from 0.15 to 0.20 kg water/kg dry solid and relative humidity from 35% to 50%) were determined from the maximum and minimum integral enthalpy and entropy values, respectively. A model was proposed to estimate the water sorption isotherms of alginates based on the alginate monomers (mannuronate, M, and guluronate, G) at low water activity (<0.4). M fraction was mainly responsible for the hygroscopicity of alginates. Alginates with similar G fraction showed different hygroscopic features by the presence of more homopolymeric G blocks that could form helical structures at low moisture content, decreasing the water affinity.Practical applicationsDetermination of water sorption isotherms is fundamental to determine the optimal storage conditions at different temperatures. Their knowledge is essential for designing drying equipment, selecting adequately drying conditions (temperature and relative humidity of air) and drying time. Mathematical models are useful to estimate equilibrium moisture content in wide ranges of water activity and temperature. The thermodynamic study also provides valuable information about energy consumption and consequently operational costs. In this case, high content of mannuronate, M, increases the hygroscopic character of alginates, but the optimal moisture content of dried alginates to achieve maximum stability during storing varies in a narrow interval (0.15–0.20 kg water/kg dry solid).
Nutritional, technological, and sensory changes induced by different drying methods on purees made with Andean grains
Authors: Jimenez Dolores , Lobo Manuel , Mota Carla , Castanheira Isabel , Sammán Norma 
Published: September 2022

AbstractA fresh baby puree (FP) was elaborated with quinoa and amaranth flours (native and germinated), and the nutritional, technological, and sensory changes induced by different drying methods were investigated: lyophilization (LD), forced convection (CD), and extrusion (ED). FP had an amino acids content appropriate for baby consumption; ED had lower digestibility (75%) compared with CD (82%) and LD (83%). ED had the highest water absorption capacity (2.2 g/g). Rehydrated LD had the lightest color (L* = 67), while rehydrated ED (L* = 59) was the darkest. Rehydrated ED had the highest hardness (335 N), adhesiveness (1199 N.m), and chewiness (209 N). Both rehydrated LD and CD were described as having an intense, bitter, and strange flavor; while rehydrated ED was described as dark, consistent, sweet, fruity, and presented the best acceptability. Therefore, the appropriate method to obtain dehydrated baby purees was extrusion.Novelty impact statementBabies are a vulnerable age group because they have an underdeveloped digestive system; therefore, the use of nutritionally improved foods, such as those obtained from germination, could give added value to the products developed for them. In this study, the characteristics of a gluten‐free baby puree formulated with germinated Andean grains were highlighted; furthermore, as the dehydration could increase the shelf life and availability of the puree, it was dried by different methods. The rheological, textural, and sensory characteristics of the rehydrated puree were studied, leaving for later publications the study of the generation of anti‐nutritional or toxic compounds during drying.
The diagnostic yield of pan‐enteric capsule endoscopy in inflammatory bowel disease: A systematic review and meta‐analysis
Authors: Tamilarasan Aravind Gokul , Tran Yvonne , Paramsothy Sudarshan , Leong Rupert 
Published: September 2022

AbstractBackground and AimCapsule endoscopy (CE) is a non‐invasive diagnostic modality enabling real time video imaging of the gastrointestinal (GI) mucosa. Pan‐enteric capsule endoscopy (PCE) is now able to thoroughly assess the entire GI tract, including for inflammatory bowel disease (IBD). Our aim was to evaluate the diagnostic accuracy of PCEs in IBD.MethodsWe comprehensively searched electronic databases (MEDLINE, SCOPUS, EMBASE, and Cochrane Central Register of Controlled Trials) for studies comparing the diagnostic accuracy of PCE with endoscopic evaluation, intestinal ultrasound or magnetic resonance enterography (MRE). Data were analyzed by calculating forest plots and the use of the I2 statistic for heterogeneity.ResultsFourteen studies were identified, with seven studies evaluating PCE diagnostic yield in Crohn's disease (CD) and seven studies in ulcerative colitis (UC). In CD, there was a trend to superiority of PCE over MRE and colonoscopy with a pooled odds ratio (OR) of 1.25 (95% CI, 0.85–1.86%) for the detection of CD. This translates to an increased diagnostic yield of 5% and 7% for PCE compared with MRE and colonoscopy, respectively. PCEs had a diagnostic sensitivity for the detection of UC of 93.8% (95% CI, 87.6–97.0%) and a specificity of 69.8% (95% CI, 38.2–89.6%).ConclusionPCEs have a comparable diagnostic yield to colonoscopy and MRE in Crohn's disease. The major difficulty remains standardization of PCE scoring systems and the lack of transmural assessment. In UC, PCE has an excellent diagnostic sensitivity and positive predictive value, but there are limitations to its use including the lack of histologic assessment and poor specificity.
Which therapist perceptions best predict client outcomes? A naturalistic examination
Authors: Wu Qiong , McWey Lenore M. , Ledermann Thomas 
Published: September 2022

AbstractExamining associations between therapists' perceptions of therapy sessions and client‐reported outcomes in naturalistic settings (real‐life therapy settings) can provide valuable guidance for the assessment, treatment, and monitoring of clients. This study included data of 1334 sessions from 127 clients (86 individual and 41 couple cases) and 15 therapists, collected at a therapy training center. Clients reported their personal functioning and individual symptoms before each session. Therapists rated clients' participation, receptivity, session progress, goal progress, and therapeutic alliance at the end of each therapy session. Multilevel Structural Equation Modeling analyses revealed that therapist‐rated client participation and goal progress predicted better personal functioning, beyond clients' previous personal functioning scores. In contrast, none of therapist‐rated session variables predicted clients' individual symptoms, beyond previous symptom scores. Power analyses suggested sufficient statistical power to detect small effect sizes. Findings of the current study have clinical implications for treatment planning and progress monitoring.
Exploring the combination of tumor‐stroma ratio, tumor‐infiltrating lymphocytes, and tumor budding with WHO histopathological grading on early‐stage oral squamous cell carcinoma prognosis
Authors: Silva Gabriela Vivili Domingues , da Silva Dolens Eder , Paranaíba Lívia Máris Ribeiro , Ayroza Ana Lúcia Carrinho , Gurgel Rocha Clarissa Araujo , Almangush Alhadi , Salo Tuula , Brennan Peter A. , Coletta Ricardo D. 
Published: September 2022

AbstractBackgroundWhile the relevance of the World Health Organization histopathological grading system as a prognostic tool for oral squamous cell carcinoma has received many critics, other histopathological features such as tumor‐stroma ratio, tumor‐infiltrating lymphocytes, and tumor budding are displaying promising results. Here, we evaluated the prognostic impact of the incorporation of tumor‐stroma ratio, tumor‐infiltrating lymphocytes, and tumor budding into World Health Organization histopathological grading for patients with oral squamous cell carcinoma.MethodsA total of 95 patients with early‐stage oral squamous cell carcinoma were enrolled in the study, and World Health Organization tumor grading, tumor‐stroma ratio, tumor‐infiltrating lymphocytes, and tumor budding were evaluated in surgical slides stained with hematoxylin and eosin. Survival analyses for cancer‐specific survival and disease‐free survival were performed using Cox regression models, and receiver operating characteristic curves were applied for assessment of the performance of the combinations.ResultsTumor‐stroma ratio (stroma‐rich) was significantly and independently associated with both shortened cancer‐specific survival and poor disease‐free survival, individually and in combination with World Health Organization histopathological grading. The combination of tumor‐stroma ratio with World Health Organization grading did not improve the discriminatory ability compared to tumor‐stroma ratio alone. Although low tumor‐infiltrating lymphocytes were associated with shortened cancer‐specific survival, the association did not withstand multivariate analysis. However, in combination with World Health Organization grading, low tumor‐infiltrating lymphocytes were independently associated with poor cancer‐specific survival. The combination of tumor‐infiltrating lymphocytes and World Health Organization histopathological grading displayed a better discrimination of poor cancer‐specific survival than tumor‐infiltrating lymphocytes alone, but not at a significant level.ConclusionOur findings support tumor‐stroma ratio as a potential prognostic marker for patients with oral squamous cell carcinoma, and the incorporation of tumor‐infiltrating lymphocytes into the World Health Organization grading system improves the prognostic ability of the tumor grading alone.
Noradrenaline use for neonatal circulatory support
Authors: Hong Lisa , Davies Mark , Whitfield Karen 
Published: September 2022

AimNoradrenaline (NA) has been used in preterm and term infants for circulatory support due to conditions including sepsis and pulmonary hypertension of the newborn. Treatment in neonates varies widely between institutions and respective neonatologists. The aim of this study is to determine the indications, use and effects of NA in preterm and term infants requiring circulatory support at the Royal Brisbane and Women's Hospital neonatal intensive care unit. We also aim to determine whether there were any differences between neonates who survived versus those who died after NA treatment.MethodsData were collected from Royal Brisbane and Women's Hospital neonatal unit database including preterm and term infants between 1 January 2016 and 31 May 2021. Analysis included indication for use, blood pressure response, perfusion parameters, haemodynamic indicators and adverse effects.ResultsNA treatment was documented in 37 patients requiring treatment of cardiovascular compromise. In 11 (30%) of these infants the indication for use was due to sepsis, 19 (51%) infants had pulmonary hypertension of the newborn, and 7 (19%) infants were diagnosed with hypotension prior to NA administration. Infants who subsequently died (49%) represented a younger gestational age population and exhibited worse cardiac compromise prior to NA administration. Tachycardia occurred in 15 (31%) infants and 1 (2.7%) infant developed transient hypertension. Overall improvement in poor tissue perfusion was seen after NA use.ConclusionNA use in treating neonates requiring circulatory support appears to be effective. Further prospective trials into NA use as a first‐ or second‐line inotropic agent would be valuable.
Canonical and noncanonical pyroptosis are both activated in periodontal inflammation and bone resorption
Authors: Zhang Rui , Wu Zhiwu , Li Mingming , Yang Jin , Cheng Ran , Hu Tao 
Published: September 2022

AbstractBackground and ObjectivePyroptosis has both a caspase‐1‐dependent canonical pathway and a caspase‐4/‐5/‐11‐dependent noncanonical pathway. They play an important role in inflammatory damage and related diseases. Canonical pyroptosis was reported to be involved in periodontitis. However, knowledge of caspase‐4/‐5/‐11‐dependent noncanonical pathway involvement remains limited. The aim of this study was to investigate the outcomes of pyroptosis inhibition on periodontitis as well as the possible mechanism, in order to provide a potential target for alleviating periodontitis.MethodsHuman and rat periodontitis tissues were collected for immunohistochemistry (IHC). Micro‐computed tomography was used to assess alveolar bone loss in experimental periodontitis model. Pyroptosis‐related proteins were tested by western blot. propidium iodide staining and lactate dehydrogenase release were used to verify pyroptosis activation. RNA sequencing was applied to investigate the preliminary mechanism of the reduced periodontal inflammation induced by YVAD‐CHO.ResultsBoth canonical‐ and noncanonical‐related proteins were detected in human and rat periodontitis tissue. The pyroptosis‐inhibited group demonstrated less inflammatory response and bone absorption. In vitro, pyroptosis was activated by lipopolysaccharide and inhibited by YVAD‐CHO. RNA sequencing demonstrated that the expression of A20 and IκB‐ζ was increased and verified by western blot in vitro and IHC in vivo.ConclusionThese results suggest that inhibition of pyroptosis‐reduced inflammation and alveolar bone resorption in periodontitis.
Risk of drug‐induced liver injury in chronic hepatitis B and tuberculosis co‐infection: A systematic review and meta‐analysis
Authors: Chou Christina , Veracruz Nicolette , Chitnis Amit S. , Wong Robert J. 
Published: September 2022

AbstractPatients with tuberculosis (TB) disease treated with multi‐drug regimens are at risk of developing drug induced liver injury (DILI), and DILI risk might be even higher in patients with underlying liver disease. We aimed to evaluate whether underlying chronic hepatitis B virus (HBV) and TB co‐infection are associated with a higher risk of TB therapy‐related DILI. We conducted a systematic review and meta‐analysis using MEDLINE/PubMed from inception to 31 December 2021. Primary outcome assessed was development of DILI following multi‐drug TB treatment. Meta‐analysis using random‐effects models were utilized to evaluate whether underlying chronic HBV was associated with increased risk of DILI in patients undergoing active TB treatment. A total of 10 studies met inclusion criteria to be analysed, among which 520 patients had HBV‐TB co‐infection and 2988 patients had active TB disease without HBV. Prevalence of DILI was 21.9% in HBV‐TB co‐infected patients and 11.9% in TB patients without HBV. On meta‐analysis, HBV‐TB co‐infected patients had significantly higher risk of DILI when treated with TB therapies compared with TB patients without HBV (pooled risk ratio 1.98, 95% CI 1.38–2.83, I2 = 68%). Sub‐analysis of prospective cohort studies conducted after year 2000 detected a pooled risk ratio of 2.75 (95% CI 2.10–3.59, I2 = 0%). In conclusion, HBV‐TB co‐infected patients undergoing multi‐drug TB therapy have 2–3 times higher risk of DILI compared with TB patients without HBV. Routine HBV screening prior to initiation of TB therapy is critical for early identification of HBV‐TB co‐infection, so that clinicians can modify TB and HBV treatment and management to reduce risks of DILI.
Supporting women with learning disabilities in infant feeding decisions: UK health care professionals' experiences
Authors: Dowling Sally , Douglass Emma , Lucas Geraldine , Johnson Clare 
Published: September 2022

AbstractWomen with learning disabilities are less likely to breastfeed than other women. They may find it hard to understand or learn feeding techniques or know that they have infant feeding choices. This population may be supported during their pregnancies by a range of professionals with differing priorities and responsibilities towards both the mother and the baby. This puts considerable pressure on health care professionals including, but not limited to, midwives, infant feeding specialists, health visitors and learning disability nurses. Those who support women with learning disabilities through their journey into motherhood have a responsibility to ensure the women in their care have the information they need to make decisions about a range of issues, including infant feeding. In the absence of dedicated lactation consultants, this is one of many issues to be discussed within time‐limited appointments. Little is known about the experience of supporting women with learning disabilities to make infant feeding decisions from the point of view of health professionals. Using a qualitative descriptive research design, we conducted online, semistructured interviews with seven UK health professionals about their experience of supporting women with learning disabilities in infant feeding. Thematic analysis identified three themes: the importance of health professionals' having unconditional, positive regard; the need for an individualised approach to supporting women to make infant‐feeding decisions; and being part of the support network. This suggests that women with learning disabilities can make and put into practice infant feeding decisions if they have access to the right support at the right time.
Reflections on the nursing theory movement
Authors: Thorne Sally 
Published: September 2022

AbstractThis manuscript represents one segment of a philosophical conversation held in a virtual webinar in February 2021 to consider some of the current debates in nursing theory, education and practice, and their relationship to philosophy. The webinar was sponsored by the International Philosophy of Nursing Society and the Centre for Nursing Philosophy at University of California, Irvine as an opportunity provide a venue for important philosophical and theoretical thinking to a wide audience of nurse educators and practitioners around the world.
Photodynamic Therapy for Bladder Cancers, A Focused Review†
Authors: Rahman Kazi Md Mahabubur , Giram Prabhanjan , Foster Barbara A. , You Youngjae 
Published: September 2022

AbstractBladder cancer is the first cancer for which PDT was clinically approved in 1993. Unfortunately, it was unsuccessful due to side effects like bladder contraction. Here, we summarized the recent progress of PDT for bladder cancers, focusing on photosensitizers and formulations. General strategies to minimize side effects are intravesical administration of photosensitizers, use of targeting strategies for photosensitizers and better control of light. Non‐muscle invasive bladder cancers are more suitable for PDT than muscle invasive and metastatic bladder cancers. In 2010, the FDA approved blue light cystoscopy, using PpIX fluorescence, for photodynamic diagnosis of non‐muscle invasive bladder cancer. PpIX produced from HAL was also used in PDT but was not successful due to low therapeutic efficacy. To enhance the efficacy of PpIX‐PDT, we have been working on combining it with singlet oxygen‐activatable prodrugs. The use of these prodrugs increases the therapeutic efficacy of the PpIX‐PDT. It also improves tumor selectivity of the prodrugs due to the preferential formation of PpIX in cancer cells resulting in decreased off‐target toxicity. Future challenges include improving prodrugs and light delivery across the bladder barrier to deeper tumor tissue and generating an effective therapeutic response in an In vivo setting without causing collateral damage to bladder function.