bluuebunny/crossref_metadata_2025_split huggingface dataset:
UGDH promotes tumor-initiating cells and a fibroinflammatory tumor microenvironment in ovarian cancer
Authors: Harrington Brittney S. , Kamdar Rahul , Ning Franklin , Korrapati Soumya , Caminear Michael W. , Hernandez Lidia F. , Butcher Donna , Edmondson Elijah , Traficante Nadia ,   Australian Ovarian Cancer Study Group, Gough Madeline , Rogers Rebecca , Lourie Rohan , Shetty Jyoti , Tran Bao , Elloumi Fathi , Abdelmaksoud Abdalla , Lal Nag Madhu , Mazan-Mamczarz Krystyna , House Carrie D. , Hooper John D. , Bowtell David D. L. , Annunziata Christina M. 
Published: October 2022

AbstractEpithelial ovarian cancer (EOC) is a global health burden, with the poorest five-year survival rate of the gynecological malignancies due to diagnosis at advanced stage and high recurrence rate. Recurrence in EOC is driven by the survival of chemoresistant, stem-like tumor-initiating cells (TICs) that are supported by a complex extracellular matrix (ECM) and immunosuppressive microenvironment. To target TICs to prevent recurrence, we identified genes critical for TIC viability from a whole genome siRNA screen. A top hit was the cancer-associated, proteoglycan subunit synthesis enzyme UDP-glucose dehydrogenase (UGDH). Immunohistochemistry was used to delineate UGDH expression in histological and molecular subtypes of EOC. High UGDH expression was observed in the majority of high-grade serous ovarian cancers with variable expression in clear cell, mucinous and endometrioid histotypes. A distinctive prognostic difference was revealed when serous cancers were stratified by molecular subtype, where high UGDH was associated with poor prognosis in the C1/Mesenchymal subtype and low UGDH was associated with poor prognosis in the C4/Differentiated subtype. Ovarian cancer cell lines were subtyped according to the molecular subtypes, and we examined the effect of modulating UGDH expression in cell lines representing the C1/Mesenchymal subtype and C4/Differentiated subtypes. Knockdown of UGDH in the C1/Mesenchymal subtype reduced spheroid viability, sphere-formation and the CD133+/ALDH high TIC population. Conversely, overexpression of UGDH in the differentiated subtype enhanced spheroid formation but reduced the TIC population. Inflammatory cytokine expression was altered by UGDH expression. In co-culture models, altering UGDH expression in spheroids affected the gene expression of mesothelial cells causing changes to matrix remodeling proteins. The effect of UGDH knockdown or overexpression in the C1/Mesenchymal and C4/Differentiated subtypes, respectively, was tested on mouse intrabursal xenografts and showed dynamic changes to the tumor stroma. Knockdown of UGDH reduced tumor burden in C1/Mesenchymal xenografts compared to controls. These data show that modulation of UGDH expression in tumors influences cells in the microenvironment and reveals distinct roles for UGDH in the mesenchymal and differentiated molecular subtypes of EOC. UGDH is a potential therapeutic target in TICs, for the treatment of metastatic and recurrent EOC, particularly in patients with the mesenchymal molecular subtype.
Surface glia predominantly contribute to the development of ALS/FTD in Drosophila model
Authors: Snow Brittany Anne , Stevenson Ciara Crowley , Kaur Jasdeep , Lee Seung Gee , Wei Yanan , Miao Hongyu , Kim Woo Jae 
Published: October 2022

ABSTRACTAmyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized by motor neuron degeneration in the primary motor neurons. C9orf72 repeat expansion mutation is the most prevalent genetic causes of ALS/FTD. Due to the complexity of ALS, there has been no successful therapy for the condition. The traditional neurocentric concept of ALS derives in part from the assumption that the degradation of motor neuron (MN) cells in ALS is driven by cell-autonomous mechanisms, however, recent research has focused on the non-cell-autonomous pathogenic mechanisms such as glial, immune cells and blood-brain barriers participate in the degeneration of MNs in ALS. Drosophila melanogaster is widely used as a genetic model for ALS, giving essential mechanistic data on disease onset and development. Using newly developed genetic tools to individually mark each subtype of the adult glial system in the fruit fly, we demonstrate that surface glia are the major glial subtypes for the pathogenesis of C9orf72-mediated ALS/FTD.
Comparison of interferometric light microscopy with nanoparticle tracking analysis for the study of extracellular vesicles and bacteriophages
Authors: Sausset Romain , Krupova Zuzana , Guédon Eric , Peron Sandrine , Grangier Alice , Petit Marie-Agnès , De Sordi Luisa , De Paepe Marianne 
Published: October 2022

ABSTRACTResearch on extracellular vesicles (EVs) and bacteriophages (phages) has been steadily expanding over the past decades as many of their roles in medicine, biology, and ecosystems have been unveiled. Such interest has brought about the need for new tools to quantify and determine the sizes of these biological nanoparticles. A new device based on interferometric light microscopy (ILM), the Videodrop, was recently developed for this purpose. Here, we compared this new device to two nanoparticle tracking analysis (NTA) devices, the NanoSight and the ZetaView, for the analysis of EVs and phages. We used EVs isolated from bacteria, fecal samples, bovine milk and human cells, and phages of various sizes and shape, ranging from 30 to 120 nm of diameter. While NTA instruments correctly enumerated most phages, the Videodrop detected only the largest one, indicating a lower sensitivity threshold compared to the NTA devices. Nevertheless, the performance of the Videodrop compared favorably to that of the NTA devices for the determination of the concentration of eukaryotic EV samples. The NanoSight instrument provided the most precise size distributions but the Videodrop was by far the most time-saving device, making it worthy of consideration for studies conducted on a large number of samples.
The plastidial protein MRC promotes starch granule initiation in wheat leaves but delays B-type granule initiation in the endosperm
Authors: Chen Jiawen , Chen Yi , Watson-Lazowski Alexander , Hawkins Erica , Barclay J. Elaine , Fahy Brendan , Denley Bowers Robin , Corbin Kendall , Warren Frederick J. , Blennow Andreas , Uauy Cristobal , Seung David 
Published: October 2022

AbstractThe spatial and temporal patterns by which starch granules initiate vary greatly between species and organs, but molecular factors that contribute to these diverse patterns are poorly understood. We reveal distinct organ-specific roles of the MYOSIN-RESEMBLING CHLOROPLAST PROTEIN (MRC) in regulating granule initiation in the endosperm and leaves of wheat. We isolated three independent TILLING mutants of tetraploid wheat (Triticum turgidumcv. Kronos) with premature stop or missense mutations in the A-genome homeolog, which we showed to be the only active homeolog in tetraploid wheat due to a disruption of the B-genome homeolog. Wheat endosperm contains both large A-type granules initiated during early grain development, and small B-type granules that initiate about 10 – 15 days later. Themrcmutants had significantly smaller A-type granules and a higher relative volume of B-type granules in the endosperm than the wild type. Whereas B-type granules initiated 15 - 20 days post anthesis (dpa) in the wild-type, they appeared as early as 10 dpa in themrc-1mutant, suggesting a role for MRC in suppressing B-type granule initiation during early grain development. By contrast, MRC promotes granule initiation in leaves: mutants carrying premature stop mutations inMRChad fewer granules per chloroplast than the wild type. These contrasting roles of MRC among wheat organs provide new insight into functional diversification of granule initiation proteins, and suggest that they may facilitate the diverse patterns of granule initiation observed across species and organs.
The gold price – Inflation relation in the case of Vietnam: empirical investigation in the presence of structural breaks
Authors: Duong Thuy Hang 
Published: October 2022

PurposeThis paper investigates the relationship between domestic gold prices and inflation in Vietnam based on the monthly series of the gold price index and consumer price index over the period of December 2001–July 2020.Design/methodology/approachThe co-integration between the domestic gold price and inflation is examined within the autoregressive distributed lag-error correction (ARDL bounds testing) framework. This paper also applies the vector error correction model (VECM) and impulse response function analysis to explore the causal relationship between these two variables. Moreover, since both gold and inflation series are likely to have structural changes over time, a unit root test controlling for significant breaks is employed in this paper.FindingsFindings from the ARDL bounds testing model suggest the presence of a co-integration between the underlying variables. The VECM indicates that shocks in inflation lead to a negative response to gold prices in the long run. In the short term, only fluctuations in gold prices impact inflation, and this causality is unidirectional.Research limitations/implicationsGold is regarded as a critical financial asset to preserve wealth from inflation pressure in the case of Vietnam. These findings propose implications for both investors and policymakers.Originality/valueEmpirical results suggest that inflation has a long-term impact on gold prices in the Vietnamese market. In the existence of a permanent inflationary shock, domestic prices of gold respond negatively to this shock; hence, gold can act as a good hedge against inflation in Vietnam.
Use of work-space at home under COVID-19 conditions in the UAE
Authors: Hiyasat Rund , Sosa Marco , Ahmad Lina 
Published: October 2022

PurposeThe study assesses user satisfaction of workspaces modified at home in response to the COVID-19 pandemic, thereby analyzing the flexibility of modern homes in the twenty-first century in the United Arab Emirates.Design/methodology/approachData was collected using a structured online survey from 113 participants about their home office created to accommodate working/studying from home. Analysis of survey revealed the importance of type of residence in affecting satisfaction of functionality and well-being.FindingsThe collected demographic variables played a crucial role in affecting satisfaction with various elements, from indoor air quality of the working space to the amount of natural light received by the space. Finally, participants who felt the need to add color and change furniture layout, experienced feelings of productivity, commitment and motivation by working from home. The same participants decided to keep the amended changes to their living spaces, even after they return to working from their offices. The study concludes by presenting implications of this experience on future home designs; thereby offering suggestions of authorities, and designers to produce more flexible and resilient houses.Research limitations/implicationsA relatively small sample with limited professions was considered. Further research recommendations include increasing the sample size to target more categories of the residents of the UAE. Future research can expand the criteria used to evaluate satisfaction and include noise levels as well as accessibility.Practical implicationsThe study offers suggestions to authorities and designers to produce more flexible and resilient homes, taking demographics into consideration. Roof gardens, shading devices and privacy needs are crucial elements for the future home.Originality/valueThe research provides enough information to inform designers about the future of space interiors, how well they are configured, serviced and how adaptable they are, in order to enhance user satisfaction.HighlightsSatisfaction was affected by individual differences.Those who changed furniture layout showed least average satisfaction.Females reported higher satisfaction with indoor air quality and lighting than males.
PetroSahand International Group: investigating the reasons for strategy implementation failure – focusing on organization capitals such as alignment, leadership, and organizational culture
Authors: Dehghan Salmasi Soroush , Nasr Arash Khalili , Dadashzadeh Yashar 
Published: October 2022

Learning outcomes
After completing the case, students will be able to understand the reasons for the lack of successful strategy implementation in companies, especially engineering, procurement and construction (EPC) and general contractors in Iran’s oil, gas and petrochemical industry; understand the importance of alignment as an organization capital in successful strategy implementation and familiarize themselves with assessing the alignment readiness of companies; understand the importance of leadership as an organization capital in successful strategy implementation, comprehend one of the most essential theories of leadership in the world of management and familiarize themselves with assessing leadership readiness using this theory; and understand the importance of leadership as an organization capital in successful strategy implementation, comprehend one of the most essential models of organizational culture in the world of management and understand how to assess the readiness of organizational culture in companies.

Case overview / synopsis
This case discusses the reasons for strategy implementation failure at PetroSahand International Group, one of the most prominent EPC and general contractors in the oil, gas and petrochemical industry in Iran. This case also examines organization capitals such as alignment, leadership and organizational culture, the three most important factors for the successful implementation of strategies, at this company. PetroSahand is an international, project-oriented company that has been able to successfully complete more than 100 large domestic and international projects during its four decades of activity. However, the company is currently facing many difficulties such as overdue debts and projects.

Complexity academic level
The target audience of this case are graduates and undergraduates in the courses of Strategic Planning, Strategic Management, Strategy Implementation, Strategy in Action and Change Management. Additionally, this case study can be useful for senior managers of companies and can help in the successful implementation of strategies as well as improving their company’s alignment, leadership and organizational culture.

Supplementary materials
Teaching Notes are available for educators only.

Subject code
CSS 11: Strategy.
The effects of fear of missing out on social media posting preferences
Authors: Xi Yue , Huo Jiale , Zhao Xinran , Jiang Yushi , Yang Qiang 
Published: October 2022

Purpose
Fear of missing out (FOMO) has become a common phenomenon on social media. This study aims to examine how FOMO influences consumer preferences for posting about identity-relevant products on social media.

Design/methodology/approach
In this research, three studies were conducted to explore the effects of FOMO in different real-life situations. Study 1 was conducted in a laboratory setting in China. Study 2 includes two experiments, one that was conducted in China and one in the USA. Study 3 was conducted in a workplace setting in China.

Findings
The results of Study 1 indicate that when consumers experience FOMO, they prefer to post about identity-relevant (vs functional) products to a greater extent than usual. Study 2 examines the role of self-esteem and identifies self-presentation and the avoidance of social attention as underlying mechanisms. Thus, consumers with high (or low) self-esteem tend to be more motivated to present themselves positively (or to avoid social attention) when experiencing FOMO. Furthermore, Study 3 reveals the moderating role of supportive interactions; that is, the interaction between FOMO and consumer self-esteem is most likely to exert an effect when consumers receive many supportive interactions.

Research limitations/implications
This research demonstrates that posting identity-relevant content on social media is a coping strategy that individuals may adopt when experiencing FOMO. Moreover, self-esteem can predict how individuals cope with FOMO by identifying self-presentation and avoidance of social attention as the mechanisms underlying effects. Although this research attempts to avoid interference from other factors between in the relationship FOMO and the control conditions, it seems possible that more socially relevant information may be presented in the FOMO condition.

Practical implications
Because FOMO can be manipulated and posting types can be predicted, this research provides important implications for brands on how to create or post content to better engage consumers.

Originality/value
This research supports the role of FOMO as a driver of on consumer posting preferences on social media.
Actores sociales construyendo visiones comunitarias en el sur global
Authors: Vargas Lama Fredy 
Published: October 2022

Propósito
Identificar los aspectos que los Actores Sociales consideran en la construcción de futuros compartidos en las comunidades. En su aplicación en los países emergentes, especialmente en el Sur Global, a menudo se pasan por alto las particularidades socioculturales de las comunidades y los actores, generando fricciones o conflictos sociales. Este artículo presenta dos elementos críticos que contribuyen al debate: a) la importancia de entender a los Actores Sociales dentro de un modelo de generación de futuros comunitarios en los países emergentes; b) los factores relevantes que influyen en los actores en un ejercicio de construcción de futuros en las comunidades.

Diseño/metodología/enfoque
A partir de la investigación cualitativa, se utilizó un estudio de caso de prospectiva comunitaria del futuro: El futuro de Puerto Gaitán 2037 (Meta, Colombia). Se aplicó un método de recolección de información a partir de la observación de los participantes y el análisis de la documentación. El método de análisis fue el DQA (Análisis Cualitativo Deductivo).

Hallazgos
La participación de Los Actores Sociales presenta un modelo de cinco elementos relevantes que influyen en los actores para la construcción exitosa de futuros en las comunidades. Los primeros cuatro factores, revelados por la teoría, existen en la realidad. Asimismo, se demuestra un quinto factor: el Pensamiento a Largo Plazo, que se evidencia en un Modelo de aplicación de Estudios de Futuros para el contexto específico, aplicable al caso de comunidades en países del Sur Global.

Originalidad/valor
Si bien existen ejemplos aislados de recomendaciones respecto a estudios para generar el futuro de las comunidades, este es el primer estudio que presenta factores concretos que contribuyen a orientar la construcción de futuros comunitarios desde Actores Sociales, especialmente en países del Sur Global como Colombia. También es uno de los primeros estudios en utilizar el DQA como método de análisis en un tema de Estudios de Futuros.
Resin finishing of hessian fabric for potential application as a semi-rigid packaging material
Authors: Sarkar P.C. , Lakshmanan Ammayappan , Kumar Niranjan 
Published: October 2022

Purpose
The purpose of this study is to enhance the functional properties of Hessian fabric through resin finishing. Hessian bags made of lignocellulosic jute fiber are commonly used to pack, store and transport agro-commodities, including horticultural crops such as rice, potato, onion and wheat. However, because of high water affinity, these bags undergo degradation in properties due to moisture release by the stored commodities themselves. Exposure to natural elements, e.g. rain and dew, also causes moisture absorption in hessian bags. Once the bag gets moistened, degradation of jute bags starts due to microbial attack, leading to loss in tensile strength and change in extensibility, leading to ultimate breakage in warp and weft directions of the fabric.

Design/methodology/approach
To overcome the degradation in the functional properties of hessian fabric due to exposure to moisture and microbial attack, the application of semi-synthetic polymeric materials was carried out.

Findings
Tenacity, bursting strength, puncture resistance, tear strength and breaking load, as well as life cycle of resin-treated jute fabric was found to be better than control jute.

Originality/value
To the best of the authors’ knowledge, no recent reports of resin finishing on jute (hessian) fabric with semi-synthetic resins are presently available, other than coating with rubber.
Evaluation of low-cost electronic sensors for monitoring soil moisture in an experimental area in the Brazilian semiarid
Authors: Cruz Macedo dos Santos Maria Angela , Vellame Lucas Melo , Silva Alisson Jadavi Pereira , de Araújo José Carlos , Amaral Alisson Macendo 
Published: October 2022

Purpose
This paper aims to determine and evaluate the calibration curve for low-cost electronic sensors in soils from a reclaimed and degraded area in the Brazilian semiarid region.

Design/methodology/approach
The probes were made, programmed and inserted in soil previously conditioned in polyethylene cylinders. The sets “cylinder + probe + soil” were subjected to saturation for a period of 24 h and, subsequently, gravitational drainage at room temperature and daily weighings were performed. When the set reached constant weight, the samples were taken to dry in an oven at 105°C to determine the dry mass and later, determine the gravimetric moisture and convert it into volumetric. The volumetric moistures obtained were related to measured frequency variations and the adjustments were analyzed by regression, which was subjected to analysis of variance (p = 0.05), and related by a third-degree polynomial equation whose quality of the fit was verified with coefficient of determination (R2).

Findings
The obtained moistures were related to the estimated moistures and evaluated by the root-mean-square error and straight 1:1. The results demonstrate that the sensors are not accurate for moistures in saturation, but representative and statistically acceptable results for moistures up to field capacity.

Originality/value
This paper has not been published before in its current, or similar form.