bluuebunny/crossref_metadata_2025_split huggingface dataset:
MS1/MMD1homologs in the mossP. patensare required for male and female gametogenesis and likely for sporogenesis
Authors: Landberg Katarina , Lopez-Obando Mauricio , Vera Victoria Sanchez , Sundberg Eva , Thelander Mattias 
Published: March 2022

SummaryThe Arabidopsis Plant HomeoDomain (PHD) proteins AtMS1 and AtMMD1 provide chromatin-mediated transcriptional regulation essential for tapetum-dependent pollen formation. Such pollen-based male gametogenesis is a derived trait of seed plants. Male gametogenesis in the common ancestors of land plants is instead likely to have been reminiscent of that in extant bryophytes where flagellated sperms are produced by an elaborate gametophyte generation. Still, also bryophytes possess MS1/MMD1-related PHD proteins.We addressed the function of two MS1/MMD1-homologs in the bryophyte model mossPhyscomitrium patensby the generation and analysis of reporter and loss-of-function lines.The two genes are together essential for both male and female fertility by providing cell autonomous functions in the gamete-producing inner cells of antheridia and archegonia. They are furthermore expressed in the diploid sporophyte generation suggesting a function during sporogenesis, a process proposed related by descent to pollen formation in angiosperms.We propose that the moss MS1/MMD1-related regulatory network required for completion of male and female gametogenesis and possibly for sporogenesis, represent a heritage from ancestral land plants.
A Coiled-Coil-Based Design Strategy for the Thermostabilization of G-Protein-Coupled Receptors
Authors: Amer Marwa , Frey Daniel , Li Xiaodan , Kammerer Richard A. 
Published: March 2022

ABSTRACTThe most common methods for generating crystallizable GPCRs are scanning alanine mutagenesis and fusion to crystallization-facilitating partner proteins. The major goal of our work was to create a new GPCR tool that would provide receptor stability and additional soluble surface for crystallization. Towards this aim, we selected the two-stranded antiparallel coiled coil as a domain fold that satisfies both criteria. A selection of antiparallel coiled coils was used for structure-guided substitution of intracellular loop of the β3 adrenergic receptor. Unexpectedly, only the two GPCR variants containing thermostable coiled coils were expressed. We showed that one GPCR chimera is stable upon purification in detergent, retains ligand-binding properties, and can be crystallized. However, the quality of the crystals was not suitable for structure determination. To supply additional surface for promoting crystal contacts, we replaced in a structure-based approach the loop of the antiparallel coiled coil by T4L. Although expression is currently not suitable for structural work, we found that the engineered GPCR is even more stable than the coiled-coil variant. Our approach should be of interest for applications that benefit from stable GPCRs.
Knowledge generation and market orientation during global crises in supply chains
Authors: Martins Fellipe Silva , Vils Leonardo , Serra Fernando Antonio Ribeiro , da Silva Junior Wanderley , Napolitano Domingos Márcio Márcio Rodrigues 
Published: March 2022

Purpose
Supply chains (SCs) depend on interorganizational relationships (IORs) to function optimally, yet crises may lessen the knowledge flows therein. This paper aims to address this issue by proposing a mediation effect between knowledge generation and market orientation by crisis perception in SC.

Design/methodology/approach
Partial least square structural equation modeling was used to test the hypotheses. Data collection comprised 279 full answers of business-to-business organizations in global SCs.

Findings
The data provide evidence that, contrary to the extant literature, knowledge generation during a crisis in a SC does not mitigate crisis perception. In addition, findings suggest there are no significant differences between manufacturing and service SCs in sensemaking during crises and that during crises, SC links diminish cooperation in terms of knowledge generation and sharing and focus on individual performance.

Originality/value
The authors have found a conflicting theoretical issue – while extant literature posits setting IORs lead to high sunk cost, making IOR channels costly and reliable for information flows during crises, the behavioral perspective posits that when crises hit, exogenous shocks induce inwards focus diminishing information flows. The results provide insights on this seemingly inconsistent scenario and point to future avenues of research.
Giving form to future branding realities
Authors: Cova Bernard , Cantone Luigi , Testa Pierpaolo 
Published: March 2022

PurposeThe purpose of this study is to question the prospective relevance of conceptual articles on branding.Design/methodology/approachThe paper advocates the development of conceptual articles with prospective relevance by emphasizing two key elements – the form and the context of discovery. The paper is illustrated with empirical data on how some branding researchers have produced such conceptual articles.FindingsTo author such articles the researchers might focus more on the initial phase of theorizing, when their intuition makes it possible to imagine new reality through alternative forms. The paper also highlights a need to reconsider the role of essays in branding research, particularly in writing conceptual pieces of prospective relevance.Research limitations/implicationsThe connection between intuition and form is crucial to producing prospectively relevant conceptual articles. By evolving along the middle ground, without falling into empirical production on the one hand or guruization on the other, the researcher can give form to emerging branding phenomena.Originality/valueThe paper renews the debate on the need for more conceptual articles by focusing on a forgotten but crucial dimension: foresight relevance.
Blocking cholesterol efflux mechanism is a potential target for antilymphoma therapy
Authors: Yano Hiromu , Fujiwara Yukio , Horlad Hasita , Pan Chang , Kai Keitaro , Niino Daisuke , Ohsawa Kumiko , Higashi Morihiro , Nosaka Kisato , Okuno Yutaka , Tamaru Jun‐ichi , Mukasa Akitake , Matsuoka Masao , Komohara Yoshihiro 
Published: March 2022

AbstractCholesterol is an essential plasma membrane lipid for the maintenance of cellular homeostasis and cancer cell proliferation. Free cholesterol is harmful to cells; therefore, excessive free cholesterol must be quickly esterified by acetyl‐coenzyme A:cholesterol acetyltransferase (ACAT) and exported by scavenger receptor class B member I (SR‐BI) or ATP‐binding cassette protein A1 from specific cells such as macrophage foam cells, which contain cholesteryl ester‐derived vacuoles. Many vacuoles are present in the cytoplasm of Burkitt lymphoma cells. In this study, we observed that these vacuoles are often seen in high‐grade lymphomas. Cell culture study using lymphoma cell lines found that esterified cholesterol is the main component of these vacuoles and the expression of cholesterol metabolism‐related molecules was significantly upregulated in lymphoma cell lines, with SR‐BI and ACAT inhibitors (BLT‐1 and CI‐976, respectively) impeding lymphoma cell proliferation. Cytoplasmic free cholesterol was increased by ACAT and SR‐BI inhibitors, and the accumulation of free cholesterol induced lymphoma cell apoptosis by inducing endoplasmic reticulum stress. Furthermore, synergistic effects of SR‐BI and ACAT inhibitors were observed in a preclinical study. Treatment with SR‐BI inhibitor suppressed lymphoma progression in a tumor‐bearing mouse model, whereas ACAT inhibitor did not. Therefore, SR‐BI inhibitors are potential new antilymphoma therapeutics that target cholesterol metabolism.
The prognostic role of interatrial block among COVID‐19 patients hospitalized in medicine wards
Authors: Russo Vincenzo , Albani Stefano , Caturano Alfredo , Weisz Sara Hana , Parisi Valentina , Conte Maddalena , Zaccaro Lorenzo , D’Andrea Antonello , Al‐Turky Ahmed , Marchel Michal , Marano Marco , Sasso Ferdinando Carlo , Attena Emilio 
Published: March 2022

AbstractIntroductionSome abnormal electrocardiographic findings were independently associated with increased mortality in patients admitted for COVID‐19; however, no studies have focussed on the prognosis impact of the interatrial block (IAB) in this clinical setting. The aim of our study was to assess the prevalence and clinical implications of IAB, both partial and advanced, in hospitalized COVID‐19 patients.MaterialsWe retrospectively evaluated 300 consecutive COVID‐19 patients (63.22 ± 15.16 years; 70% males) admitted to eight Italian Hospitals from February 2020 to April 2020 who underwent twelve lead electrocardiographic recording at admission. The study population has been dichotomized into two groups according to the evidence of IAB at admission, both partial and advanced. The differences in terms of ARDS in need of intubation, in‐hospital mortality and thromboembolic events (a composite of myocardial infarction, stroke and transient ischaemic attack) have been evaluated.ResultsThe presence of IAB was noticed in 64 patients (21%). In the adjusted logistic regression model, the partial interatrial block was found to be an independent predictor of ARDS in need of intubation (HR: 1.92; p: .04) and in‐hospital mortality (HR: 2.65; p: .02); moreover, the advanced interatrial block was an independent predictor of thrombotic events (HR: 7.14; p < .001).ConclusionsAmong COVID‐19 patients hospitalized in medical wards, the presence of interatrial block is more frequent than in the general population and it might be useful as an early predictor for increased risk of incident thrombotic events, ARDS in need of intubation and in‐hospital mortality.
Network meta‐analysis of therapies for cluster headache: Effects of acute therapies for episodic and chronic cluster
Authors: Medrea Ioana , Christie Suzanne , Tepper Stewart J. , Thavorn Kednapa , Hutton Brian 
Published: March 2022

AbstractObjectiveWe used network meta‐analysis (NMA) to characterize the relative effectiveness and harms of acute treatment options for cluster headache.BackgroundThere are few evidence‐based acute treatments available for cluster headache. As most treatments were compared only against placebos in clinical trials, few head‐to‐head comparisons of treatments are available.MethodsAn a priori registered scoping review was performed to identify randomized controlled trials evaluating treatments in adult patients (>18 years old) with cluster headache per accepted diagnostic criteria. Bayesian NMAs were performed to compare treatments in terms of headache relief at 15 or 30 min, and also the occurrence of adverse events. We report odds ratios (ORs) of relative treatment effects along with corresponding 95% credible intervals (CrIs), as well as measures of treatment ranking.ResultsA total of 13 randomized controlled trials informed NMAs. We found high flow oxygen to be the most effective therapy for headache response at 15 and 30 min (OR 9.0, 95% CrI 5.3 to 15.9 vs. placebo), with injectable sumatriptan demonstrating the next highest effect (OR 6.4, 95% CrI 3.75 to 11.1 vs. placebo). High flow oxygen was also more effective than low flow oxygen (OR 2.55, 95% CrI 1.13 to 5.8), nasal spray zolmitriptan (OR 3.75, 95% CrI 1.72 to 8.4), octreotide (OR 4.5, 95% CrI 1.64 to 12.5), and non‐invasive vagal nerve stimulation (nVNS; OR 5.2, 95% CrI 2.29 to 11.9). Sumatriptan injectable was also effective for headache relief and was found to be better than nasal spray zolmitriptan (OR 2.67, 95% CrI 1.21 to 5.9), octreotide (OR 3.20, 95% CrI 1.17 to 8.8), and nVNS (OR 3.69, 95% CrI 1.63 to 8.4). Octreotide (OR 4.1, 95% CrI 1.71 to 10.5) and sumatriptan (OR 2.40, 95% CrI 1.39 to 4.2) were associated with greater risk of adverse events compared to placebo, while other treatments did not demonstrate increased risk. When focusing on patients with episodic cluster headache, nVNS was significantly better than placebo (OR 4.9, 95% CrI 1.89 to 14.1).ConclusionsOur findings suggest that high flow oxygen is more efficacious when compared to low flow oxygen for headache relief. When low flow oxygen fails in patients who can tolerate oxygen, increased flow rates should be tried. Additionally, high flow oxygen is likely more effective than zolmitriptan nasal spray, nVNS, and octreotide. Sumatriptan injectable is more likely to be effective when compared to zolmitriptan nasal spray, octreotide, and nVNS.
Food frequency questionnaire for dietary assessment among adults at a risk of coronary heart disease: A mixed‐methods study
Authors: Zhang Youjuan , Cheng Ho Yu , Zang Yuli , Choi Kai Chow , Chair Sek Ying 
Published: March 2022

AbstractAims and objectivesTo develop and psychometrically test a food frequency questionnaire for adults at risk of coronary heart disease (Cardio‐FFQ).BackgroundComprehensive dietary assessment is critical for the prevention of cardiovascular disease, but appropriate instruments to perform this work are lacking.DesignA sequential mixed‐methods study followed the COREQ and STROBE guidelines.MethodsThis study was conducted between April 2016 and November 2017. It started with dietary history interviews (Phase 1) to identify candidate food items of the Cardio‐FFQ, which validity and reliability were assessed (Phase 2) through expert consultation and four seasonal measurements, including test and retest with a 2‐week gap every season. Physical activity and blood glucose and lipids were assessed seasonally, while another FFQ was administered during the fourth measurement. Content analysis was used to analyse verbatim interview transcripts, while descriptive and inferential analyses were used to simplify the Cardio‐FFQ and examine its psychometric properties.ResultsPhase I involved 34 participants during their first onset of acute coronary syndrome and generated 176 candidate food items (consumed by at least three participants) under 12 food categories. These food items were simplified to form the 133‐item Cardio‐FFQ after discarding items with trivial contributions to food commonalities or between‐person variance. Further analysis showed that the simplified questionnaire had satisfactory content validity, concurrent validity, convergent validity, predictive validity, known‐group validity and test–retest reliability.ConclusionThe 133‐item Cardio‐FFQ is a valid and reliable tool for a comprehensive dietary assessment appropriate for adults at risk of coronary heart disease.Relevance to clinical practiceNurses may use the Cardio‐FFQ to conduct a dietary assessment to better support people to commit to healthy diets, aiming to reduce the risk of coronary heart disease.
Efficiency of oro‐facial myofunctional therapy in treating obstructive sleep apnoea: A meta‐analysis of observational studies
Authors: Zhang Feng , Tian Zhuo , Shu Yan , Zou Bin , Yao Hongbing , Li Shaojun , Li Qiu 
Published: March 2022

AbstractObjectiveThe literature on oro‐facial myofunctional therapy (OMT) in children and adults with obstructive sleep apnoea (OSA) was systematically reviewed to investigate the effects of OMT on patients with OSA by age and disease severity to verify the effect of OMT on OSA.Data sourcesAll the comparative literature was retrieved from the PubMed, Embase and Cochrane libraries.MethodWe searched the articles published up to 12 February 2022 and followed the preferred reporting project for systematic review and meta‐analysis of reports. The quality of the studies was evaluated using the Newcastle–Ottawa scale.ResultsOf the primary indicators for evaluating OSA, 13 studies reported on the apnoea index (AHI), showing a decrease in the mean standard deviation of AHI from before OMT to after OMT (p < .00001). The lowest oxygen saturation was reported in nine studies, and the mean standard deviation of the lowest oxygen saturation increased from before to after OMT (p = .0009). Ten studies reported the Epworth Sleepiness Scale (ESS), indicating that the mean standard deviation of the ESS decreased from before to after OMT (p < .00001). The subgroup analysis showed that the AHI scores indicating mild and moderate OSA were significantly reduced, and the AHI scores indicating severe OSA also decreased, but this was not statistically significant. The lowest oxygen saturation increased obviously in patients with both mild and moderate and severe OSA. Of the secondary indicators of OSA, there was a statistically significant improvement in snoring intensity (p = .0002).ConclusionOral and facial muscular function therapy can be used as a simple and non‐invasive new technique to improve the AHI, minimum oxygen saturation, ESS, and snoring intensity in patients with mild and moderate OSA and the lowest oxygen saturation in patients with severe OSA.
Purpureocillium lilacinum an emergent pathogen: antifungal susceptibility of environmental and clinical strains
Authors: Corrêa-Moreira D. , de Lima Neto R.G. , da Costa G.L. , de Moraes Borba C. , Oliveira M.M.E. 
Published: March 2022

Abstract
Purpureocillium lilacinum is a filamentous and hyaline fungus cosmopolitan, saprophytic, largely used in the biological control of plant-parasitic nematodes and insects, also considered an emerging and opportunistic human pathogen. The standard treatment for hyalohyphomycosis caused by P. lilacinum is not yet defined, since this fungus is resistant to different antifungals, in vitro and in vivo. The aim of this study was to evaluate and compare in vitro antifungal activity against environmental and clinical P. lilacinum isolates and our results demonstrated that these isolates can be resistant to newer generation triazoles, such as voriconazole, and to caspofungin, a drug of the echinocandin class. In summary, we highlight the importance of knowing the different susceptibility profiles of P. lilacinum isolates, and besides that, the emergence of uncommon human and animal opportunistic fungi, such P. lilacinum, especially during COVID-19, highlight the need for antifungal susceptibility testing of isolates since empirical therapy with different treatment schedules failed in great number of patients.
Overexpression of OsHAK5 potassium transporter enhances virus resistance in rice (Oryza sativa)
Authors: Jing Xinxin , Song Xia , Cai Shenglai , Wang Pengyue , Lu Guodong , Yu Ling , Zhang Chao , Wu Zujian 
Published: March 2022

AbstractIntracellular potassium (K+) transported by plants under the action of a number of transport proteins is crucial for plant survival under distinct abiotic and biotic stresses. A correlation between K+ status and disease incidence has been found in many studies, but the roles of K+ in regulating disease resistance to viral diseases remain elusive. Here, we report that HIGH‐AFFINITY K+ TRANSPORTER 5 (OsHAK5) regulates the infection of rice grassy stunt virus (RGSV), a negative‐sense single‐stranded bunyavirus, in rice (Oryza sativa). We found the K+ content in rice plants was significantly inhibited on RGSV infection. Meanwhile, a dramatic induction of OsHAK5 transcripts was observed in RGSV‐infected rice plants and in rice plants with K+ deficiency. Genetic analysis indicated that disruption of OsHAK5 facilitated viral pathogenicity. In contrast, overexpression of OsHAK5 enhanced resistance to RGSV infection. Our analysis of reactive oxygen species (ROS) including H2O2 and O2−, by DAB and NBT staining, respectively, indicated that RGSV infection as well as OsHAK5 overexpression increased ROS accumulation in rice leaves. The accumulation of ROS is perhaps involved in the induction of host resistance against RGSV infection in OsHAK5 transgenic overexpression rice plants. Furthermore, RGSV‐encoded P3 induced OsHAK5 promoter activity, suggesting that RGSV P3 is probably an elicitor for the induction of OsHAK5 transcripts during RGSV infection. These findings indicate the crucial role of OsHAK5 in host resistance to virus infection. Our results may be exploited in the future to increase crop yield as well as improve host resistance via genetic manipulations.
Learning from Aotearoa: Water governance challenges and debates
Authors: Harris Leila M. 
Published: March 2022

AbstractThe New Zealand experience continues to make an outsized imprint in water governance scholarship globally. The articles collected here press forward frontiers in hydrosocial and narrative approaches to water politics, reporting much‐needed grounded accounts of governance experimentation and providing critical insight into approaches towards decolonizing environmental governance. Although the contributions are – and must be – carefully situated within the specific historical and geographical context of Aotearoa, they do not shy away from the ‘big questions’ and have much to offer international readers.
Immunosuppressant‐associated eruptions in pediatric inflammatory bowel disease: A case‐control study
Authors: Pollard Bruin , Utterson Elizabeth C. , Samson Charles M. , Coughlin Carrie C. 
Published: March 2022

AbstractParadoxically, immunosuppressive therapy for inflammatory bowel disease (IBD) can induce psoriasiform or eczematous eruptions. This case‐control study identified infliximab exposure, Crohn's disease, and history of inflammatory skin conditions as significant risk factors for these eruptions in children with IBD. Our results also showed possible trends in age and race.
Construction of bilingual knowledge graph based on meteorological simulation
Authors: Wang Wenjing , Zhang Chunxiao , Li Heng , Xiao Ziwei 
Published: March 2022

AbstractGeographical simulation is the core function of virtual geographic environments (VGEs). Providing knowledge support has become a key issue in current research. The literature involves massive knowledge, especially for meteorological simulation, an important component of the geographic environment. However, this knowledge is noisy, unstructured, and difficult to share and reuse. Based on weather research and forecasting models, this study constructs a cross‐language knowledge graph to manage difficult‐to‐handle knowledge and to make complex knowledge structured and more complete. First, we propose a cross‐language knowledge graph construction framework. Second, the bidirectional long short‐term memory‐conditional random fields and translation‐based multilingual knowledge graph embedding model are used to extract knowledge and align cross‐lingual entities. Finally, the bilingual knowledge graph is visually stored with a graph database. The framework and method can provide efficient queries and analyses for the meteorological field, while helping to provide a knowledge base for knowledge‐driven VGEs.
DOES CRITICIZING INTELLIGENT DESIGN (ID) UNDERMINE DESIGN DISCOURSE IN THE QURʾĀN? A KALĀMIC RESPONSE
Authors: Malik Shoaib Ahmed , Karamali Hamza , Khalayleh Moamer Yahia Ali 
Published: March 2022

AbstractSome Muslim thinkers argue against evolution using intelligent design (ID) arguments. One possible impetus for this line of reasoning is the several indications of design mentioned throughout the Qurʾān. Therefore, criticizing ID could be seen as a direct attack on the Qurʾānic outlook. However, this article will argue that this is a false equation. The Qurʾānic design argument, as articulated in the tradition of Sunnī scholastic theology (kalām), argues for the existence of a supernatural God by acknowledging natural causes that bring about designed phenomena in the universe. By contrast, Muslim thinkers who use ID to argue against evolution are arguing for the existence of a supernatural being through the supposed inability of science to explain designed phenomena through natural causes. Thus, there is a fundamental difference between the design outlook provided in the Qurʾān versus the arguments of ID. Accordingly, this article argues that critiquing ID does not undermine the design discourse of the Qurʾān.