bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative exercise training for adults undergoing elective major vascular surgery: A systematic review
Authors: Tew Garry A. , Caisley Kim , Danjoux Gerard 
Published: January 2022

Patients undergoing major vascular surgery may have an increased risk of postoperative complications due to poor ‘fitness for surgery’. Prehabilitation aims to optimise physical fitness and risk factors before surgery to improve outcomes. The role of exercise-based prehabilitation in vascular surgery is currently unclear. Therefore, the aim of this systematic review was to assess the benefits and harms of preoperative exercise training in adults undergoing elective vascular surgery. We searched MEDLINE, Embase, CINAHL, and CENTRAL databases, trial registries, and forward and backward citations for studies published between January 2008 and April 2021. We included randomised trials that compared patients receiving exercise training with those receiving usual care or no training before vascular surgery. Outcomes included mortality, complications, and health-related quality of life (HRQOL). Three trials with 197 participants were included. All studies involved people undergoing abdominal aortic aneurysm (AAA) repair. Low-certainty evidence could not differentiate between rates of all-cause mortality. Moderate-certainty evidence indicated that postoperative cardiac and renal complications were less likely to occur in people who participated in preoperative exercise training compared with those who did not. Low-certainty evidence also indicated better postoperative HRQOL outcomes in people who undertook prehabilitation. There were no serious exercise-related adverse events. The evidence on preoperative exercise training for AAA patients is promising, but currently insufficiently robust for this intervention to be recommended in clinical guidelines. High-quality trials are needed to establish its clinical and cost-effectiveness. Research is also needed to determine the feasibility and effects of prehabilitation before lower-limb revascularisation.
Trial registration: PROSPERO ID: CRD42021245933.
Respect, interaction, immediacy and the role community plays in registering an organ donation decision
Authors: Moloney Gail , Sutherland Michael , Upcroft Leah , Clark Rachel , Punjabi-Jagdish Parul , Rienks Suzanne , Bowling Alison , Walker Iain 
Published: January 2022

BackgroundRegistering a donation decision is fundamental to increasing the number of people who donate the organs and tissues essential for transplantation, but the number of registered organ donors is insufficient to meet this demand. Most people in Australia support organ donation, but only a third have registered their decision on the Australian Organ Donor Register (AODR). We addressed this paradox by investigating how feelings of community, engendered through an ethic of hospitality and care and a non-proselytizing dialogue about organ donation, facilitated the decision to register.MethodsAn Immediate Registration Opportunity was set up in a large public hospital in NSW, Australia. The public was approached and invited to engage in an open, respectful dialogic interaction that met people where their beliefs were and allowed their concerns and fears about donation to be discussed. This included a survey that measured positive and negative beliefs about organ donation, mood, atmosphere, and feelings of community coupled with an on-the-spot opportunity to register their donation decision.ResultsOver four days, we interacted with 357 participants; 75.5% (210) of eligible-to-register participants registered on the AODR. Generalized Structural Equation Modelling highlighted that as connection to community increased, so did the salience of positive beliefs about organ donation. Positive beliefs, in turn, were negatively correlated with negative beliefs about donation and, as the strength of negative beliefs decreased, the probability of registration on the AODR increased. Participants who registered on the AODR reported stronger connection to the broader community than participants who did not register.ConclusionA respectful non-judgmental interaction that allows beliefs and concerns about organ donation to be discussed, coupled with an immediate opportunity to register, encouraged registration. Within this framework, feelings of belonging to a community were a key determinant that enabled many to make the decision to register.
Role of sacubitril-valsartan in the prevention of atrial fibrillation occurrence in patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Authors: Liu Xuehui , Liu Hongjun , Wang Lijun , Zhang Lei , Xu Qiang 
Published: January 2022

Objective
Heart failure (HF) and atrial fibrillation (AF) are often coexisting. They have common risk factors and pathophysiologic mechanisms. Sacubitril/valsartan has shown efficacy and tolerability in patients with HF. Thus, the study was performed to evaluate the impact of sacubitril/valsartan on AF occurrence in patients with HF.

Methods
The Embase and PubMed were searched from their inception date to June 2021 for all relevant randomized controlled trials (RCTs) evaluating the efficacy of sacubitril/valsartan in HF. The outcome of interest was the AF occurrence during the follow-up. Relative risks (RRs) with 95% confidence intervals (CIs) were pooled using a random-effects model.

Results
Six trials involving a total of 15,512 patients were included (7,750 randomized to sacubitril/valsartan and 7,762 to control). All trials were randomized, double-blind, and active-control. There was no significant difference in the prevention of AF occurrence between the sacubitril/valsartan group and the control group (enalapril or valsartan) in patients with HF (RR 1.07, 95%CI 0.95 to 1.19; I2 4%).

Conclusions
Sacubitril/valsartan was similar to either enalapril or valsartan in preventing the occurrence of AF in patients with HF.
Prospective Endoscopic Activity Assessment for Eosinophilic Gastritis in a Multisite Cohort
Authors: Hirano Ikuo , Collins Margaret H. , King Eileen , Sun Qin , Chehade Mirna , Abonia J. Pablo , Bonis Peter A. , Capocelli Kelly E. , Dellon Evan S. , Falk Gary W. , Gonsalves Nirmala , Gupta Sandeep K. , Leung John , Katzka David , Menard-Katcher Paul , Khoury Paneez , Klion Amy , Mukkada Vincent A. , Peterson Kathryn , Rudman-Spergel Amanda K. , Spergel Jonathan A. , Yang Guang-Yu , Rothenberg Marc E. , Aceves Seema S. , Furuta Glenn T. 
Published: January 2022

INTRODUCTION:
Eosinophilic gastritis (EG) is a chronic inflammatory disease of the stomach characterized by eosinophil-predominant gastric mucosal inflammation and gastrointestinal symptoms. The aim of this study was to prospectively evaluate endoscopic features in a large series of children and adults with EG to better understand the endoscopic manifestations and develop a standardized instrument for investigations.

METHODS:
Data were prospectively collected as part of the Consortium for Eosinophilic Gastrointestinal Disease Researchers, a national collaborative network. Endoscopic features were prospectively recorded using a system specifically developed for EG, the EG Endoscopic Reference System (EG-REFS). Correlations were made between EG-REFS and clinical and histologic features.

RESULTS:
Of 98 patients with EG, 65 underwent assessments using EG-REFS. The most common findings were erythema (72%), raised lesions (49%), erosions (46%), and granularity (35%); only 8% of patients with active histology (≥30 eosinophils/high-power field) exhibited no endoscopic findings. A strong correlation between EG-REFS scores and physician global assessment of endoscopy severity was demonstrated (Spearman r = 0.84, P < 0.0001). The overall score and specific components of EG-REFS were more common in the antrum than in the fundus or body. EG-REFS severity was significantly correlated with active histology, defined by a threshold of ≥30 eosinophils/high-power field (P = 0.0002).

DISCUSSION:
Prospective application of EG-REFS identified gastric features with a strong correlation with physician global assessment of endoscopic activity in EG. Endoscopic features demonstrated greater severity in patients with active histology and a predilection for the gastric antrum. Further development of EG-REFS should improve its utility in clinical studies.
Animal Naming Test Is Associated With Poor Patient-Reported Outcomes and Frailty in People With and Without Cirrhosis: A Prospective Cohort Study
Authors: Tapper Elliot B. , Kenney Brooke , Nikirk Samantha , Levine Deborah A. , Waljee Akbar K. 
Published: January 2022

INTRODUCTION:
Cognitive dysfunction is a major driver of care complexity, poor patient-reported outcomes, and frailty for people with cirrhosis. The performance and clinical associations of the animal naming test (ANT) in the general population are unknown. We evaluated ANT performance in a representative sample of older Americans with and without chronic liver disease (CLD).

METHODS:
We analyzed 6,661 subjects enrolled in the 2010–2016 Health and Retirement Survey, a representative cohort of >30,000 US adults. Average age of participants was 75 years. We evaluated 3 subject subgroups: (i) without CLD, (ii) noncirrhosis CLD, and (iii) cirrhosis. We determined the association between the ANT (overall) and S-ANT1 <10 (adjusted for age and education) and health status, basic and instrumental activities of daily living, healthcare utilization (care hours received and hospitalizations), and frailty measures (hand grip and walk speed).

RESULTS:
Overall, 8.2% of the sample had noncirrhotic CLD and 1.3% had cirrhosis. CLD or cirrhosis was not independently associated with ANT. Poor ANT performance was associated with poor health status and frailty overall. An S-ANT <10 was associated with fair-poor self-reported health (odds ratio [OR] 1.37; 95% confidence interval [CI]: 1.20–1.56), care hours received (incidence rate ratio [IRR] 2.39; 95% CI: 1.79–3.19), and hospitalizations (IRR 1.14; 95% CI: 1.03–1.26). S-ANT <10 was also associated with activities of daily living disability (OR 1.31; 95% CI: 1.13–1.51), instrumental activities of daily living disability (OR 1.85; 95% CI: 1.59–2.14), weaker hand grip (IRR 0.94; 95% CI: 0.92–0.96), and time to walk 2.5 m (IRR 1.23; 95% CI: 1.17–1.29).

DISCUSSION:
ANT performance is not specific to CLD/cirrhosis but is associated with patient-reported outcomes and frailty in a nationally representative sample of elderly subjects with and without CLD.
Determination and validation of pregabalin in bulk and pharmaceutical formulations by reversed phase-high performance liquid chromatography
Authors: N. Vidya D. , Chaithra R. , P. Senthil Kumar G. , R. Bhadresh D. 
Published: January 2022

A simple, specific, quick, isocratic Reversed Phase High Performance Liquid Chromatographic method was developed and validated for the analysis of Pregabalin in bulk and 5-different pharmaceutical formulations, the separation was accomplished on a C18, 5Î¼m Reverse Phase column (250 mm Ã— 4.6 mm) using a methanol : water (95:5, v/v) mobile phase. The compound was eluted isocratically at a flow rate of 0.8 ml /min. The UV detector was set at 288 nm for the detection of Pregabalin (PRG). The method was linear over the range of 5-45 Î¼g/ml and validated with respect to accuracy, precision, linearity, and specificity, limit of detection and limit of quantization. Robustness testing was also conducted to evaluate the effect of minor changes to the chromatographic system and to establish appropriate system suitability parameters. This method was used successfully for the quality assessment of 5-different pharmaceutical formulations with good precision and accuracy.Â Â Â
Quantum chemical analysis of harmful dye 3-[ (4-anilinophenyl) diazenyl] benzenesulfonate, metanil yellow
Authors: Parbat Shreyas 
Published: January 2022

In the present work, quantum chemical study of the harmful dye, metanil yellow is conducted. The optimized molecular geometry and harmonic vibrational frequencies of metanil yellow were calculated by DFT-B3LYP method with LANL2DZ basis set. The vibrational assignments were performed on the basis of the potential energy distribution (PED) of the vibrational modes. Infrared spectra and Bulk Raman spectra were also obtained and characteristic peaks for the title compound were studied. The nonlinear optical properties of the title compound were calculated and discussed. Dipole moment, polarizability and first-order hyperpolarizability of the title compound were reported in order to study nonlinear optical properties (NLO). HOMO-LUMO energy levels were also computed in order to get the bandgap energy. Global reactivity descriptors were calculated using the HOMO and LUMO to predict compound reactivity. UVâ€“Vis spectrum of the title compound was calculated using TDâ€“DFT method. The molecular orbital contributions were studied by density of states (DOSs). Mulliken atomic charges and atomic polar tensors (APT) on each atom were tabulated. A discussion of the vibrational energy of each mode is also presented in this article.Â Â Â
Influence of extraction technique on nutrient content, antioxidant and antimicrobial activity of aqueous extracts of commercial apricot kernels
Authors: HoroziÄ‡ Emir , SuljagiÄ‡ Jasmin , GojkoviÄ‡ Jasna , HalilÄeviÄ‡ Eldin , KubiÄek Darja , CiloviÄ‡ KazareviÄ‡ Ermina 
Published: January 2022

This paper presents the results of influence of extraction technique on phytochemical composition and biological activity of aqueous extracts of commercial apricot kernels. Three techniques were used for extraction: maceration, ultrasonic and Soxhlet extraction. The content of total phenols, flavonoids, bioelements, antioxidant and antimicrobial activity was analyzed in the extracts. Antioxidant activity was analyzed in vitro using DPPH and FRAP methods. Antimicrobial screening was performed by diffusion technique on reference strains from the ATCC collection. The content of total phenols and flavonoids is highest in extracts obtained by ultrasonic extraction and maceration. These techniques have proven to be the best for the extraction of macro and micronutrients. The aqueous extract obtained by maceration at 300 rpm for 3 hours showed a greater inhibitory effect against the tested microorganisms, compared to the extracts obtained by other techniques. The least efficient method of extracting bioactive components from apricot kernels is Soxhlet extraction, with the lowest dry extract yield of 5.5%.Â Â Â
Evaluation of the efficacy of a locally formulated antiseptic, for the control of disease-causing microorganisms
Authors: E. Eseyin Anthonia , O. Omale Benjamin , D. Dodo Juliet 
Published: January 2022

An antiseptic (sample A) was locally formulated. Its efficacy on the following micro-organisms; E.Coli, staphylococcus, streptococcus and bacillus species was evaluated and compared with that of Dettol and Septol. Sample A was established to be a cheap and effective antiseptic, which is capable of competing favourably with those in the Nigerian market. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) indicated that Sample A had a similar efficacy with Dettol. The P-value of the MIC results for samples A, Dettol and Septol were 0.004, 0.268 and 0.080 respectively, while the P-value of the MBC results were 0.450, 0.077 and 0.043 respectively. The standard errors of the mean were 0.079, 0.072 and 0.086 for sample A, Dettol and Septol respectively.Â Â
Comparative analysis of ascorbic acid content of three varieties of apple fruit sold in Lafia open markets, north central Nigeria
Authors: M. Akpomie Timothy , U. Augustine Abel , E. Anwani Samuel , I. Aandaka Benjamin 
Published: January 2022

Ascorbic acid, also known as vitamin C, is a water-soluble vitamin which helps to boost the immune system, fight against infectious diseas-es, aids iron absorption and formation of collagen in humans and other animals. The ascorbic acid content of three varieties of apples (Red Delicious, Granny Smith and Golden Delicious apples) sold in Lafia, Nasarawa State, Nigeria was investigated using the iodometric titration method for comparative reasons. The results obtained showed the concentrations of the ascorbic acid in all three varieties of the fruit to be not only different but statistically so. The concentration of the analytes in order of increasing magnitude is; Golden Delicious (22.83mg/100g), Granny Smith (29.26 mg/100g) and Red Delicious (38.63 mg/100g). Though the differences in the respective concentration of the fruits were statistically significant (p <0.05), these observed differences may not just be a function of the fruit variety alone but also on other possible reasons attributable to the impact of temperature, growing season, storage, shipping conditions and even post-harvest number of days as well as the maturity of the respective apple variety at the time of harvest prior to analysis. Comparatively, the analysis indicated that the three apple varieties are varied in ascorbic acid content but are all good sources vital for healthy living.Â Â
Comparative phytochemical screening and antioxidant activity of lemon grass and sweet wormwood leaves extract
Authors: R Murtala , S. I. Alhassan , H.I Rasheed , S. N. Dalhatu , S.S Bala , S.A Idris , D. C. Anyanaso 
Published: January 2022

Sweet wormwood (Artemisia annua) and lemongrass (Cymbopogon citratus) leaves were extracted with methanol, evaporated to dryness and processed for antioxidant activity and phytochemical screening. Phosphomolybdenum Reagent was prepared using standard procedure. An aliquot mixture of 2mL of extract solution (1000Âµg/mL, 500Âµg/mL, 250Âµg/mL, 125Âµg/mL, 62.5Âµg/mL, 31.25Âµg/mL and 15.625Âµg/mL) was mixed with 1.8mL of reagent solution. The samples tubes were incubated at 95Â°C for 90 minutes. The absorbance of the aqueous solutions was measured at 695nm against blank. Antioxidant activities of the plants extract were also measured in terms of hydrogen donating radical scavenging ability using the stable DPPH method. Absorbance was recorded at 517 nm against blank using a UV-Vis spectrophotometer. The result of in vitro antioxidant potential of the methanolic leaves extract showed more increase in concentration the higher the absorbance. Qualitative Phytochemical Analysis of Lemon Grass and Sweet wormwood shows the presence of phytochemical in lemongrass and sweet wormwood such as flavonoid, tannin, steroid, saponins and cardiac glycoside.Â Â
The effect of Triton X surfactants on Pb (II) transport rate using bulk liquid membrane systems
Authors: Suljkanovic Mersiha , SuljagiÄ‡ Jasmin , PaÅ¡iÄ‡ Mustafa 
Published: January 2022

Implementation of the "bulk liquid membrane" (BLM) system was investigated in terms of its efficiency for selective removal of heavy metal ions from natural resources and industrial wastewater. In this paper, the removal of lead (II) ions through a liquid membrane system and factors that influence the process were examined. The research was performed using the homemade transport cell. Two organic solvents were used as liquid membranes: 1,2-dichloroethane and chloroform. Metal ion concentration in aqueous phases was monitored by flame atomic absorption spectrophotometry, after 4 hours of experiment. Macrocyclic ether (dicyclohexano-18-crown-6) was used as ligand for Pb (II) ions. The effects of nonionic surfactants (Triton X-100, Triton X-45 and Triton X-405) added in the receiving phase of BLM system were investigated. The results showed significant increase in transport rate compared to systems without surfactants. Considering the surfactant structure, transport rate of Pb (II) ions followed the order: TX-100 >TX-45>TX-405. Presence of TX-100 increased transport of Pb (II) ions up to 78% through chloroform and 58% through 1,2-dichloroethane.Â Â
Analysis of inhibition action of acacia nilotica ethanol extract on aluminium corrosion in 1.0M HCl and NaOH
Authors: S.U Abdul , M.B Ibrahim , M. A. Ibrahim 
Published: January 2022

The proposed corrosion inhibition action of Acacia nilotica ethanol extract on aluminium corrosion in HCl and NaOH was investigated using weight loss method. The Acacia nilotica ethanol extract was found to be inactive in NaOH at all the concentrations of the inhibitor but active in HCl with increasing inhibition efficiency as inhibitor concentration and decreases as temperature increases with the highest inhibition efficiency of 95.31%. The kinetic and thermodynamics data shows that the adsorption process was feasible and endothermic adsorption process from the large negative values of Gibbâ€™s free energy (Î”G) and negative values of enthalpy (Î”H), The data indicated physisorption process of adsorption which was supported by FTIR spectra. The adsorption process was best fitted to Langmuir adsorption model.Â Â
Cadmium oxide (CdO) nanoparticlesâ€“based drug delivery in cancer prevention, prognosis, diagnosis, imaging, screening, treatment and management and its role and application in overcoming drug resistance under synchrotron and synchrocyclotron radiations
Authors: Heidari Alireza , Hotz Margaret , MacDonald Nancy , Peterson Victoria , Caissutti Angela , Besana Elizabeth , Esposito Jennifer , Schmitt Katrina , Chan Ling-Yu , Sherwood Francesca , Henderson Maria , Kimmel Jimmy 
Published: January 2022

In the current research, Cadmium Oxide (CdO) nanoparticlesâ€“based drug delivery in cancer prevention, prognosis, diagnosis, imaging, screening, treatment and management and its role and application in overcoming drug resistance under synchrotron and synchrocyclotron radiations. is investigated. The calculation of thickness and optical constants of Cadmium Oxide (CdO) Cadmium Oxide (CdO) nanoparticlesâ€“based drug delivery in cancer prevention, prognosis, diagnosis, imaging, screening, treatment and management and its role and application in overcoming drug resistance under synchrotron and synchrocyclotron radiations. produced using solâ€“gel method over glassy medium through a single reflection spectrum is presented. To obtain an appropriate fit for reflection spectrum, the classic Drudeâ€“Lorentz model for parametric diâ€“electric function is used. The best fitting parameters are determined to simulate the reflection spectrum using Lovenbergâ€“Marquardt optimization method. The simulated reflectivity from the derived optical constants and thickness are in good agreement with experimental results.Â Â Cadmium Oxide (Cdo) Nanoparticlesâ€“Based Drug Delivery in Cancer Prevention, Prognosis, Diagnosis, Imaging, Screening, Treatment and Management and Its Role and Application in Overcoming Drug Resistance Under Synchrotron and Synchrocyclotron Radiations.Â Â Â
Interdisciplinary approach to iridium (iv) oxide (IrO2) nanoparticles as weapons against cancer under synchrotron and synchrocyclotron radiations
Authors: Heidari Alireza , Hotz Margaret , MacDonald Nancy , Peterson Victoria , Caissutti Angela , Besana Elizabeth , Esposito Jennifer , Schmitt Katrina , Chan Ling-Yu , Sherwood Francesca , Henderson Maria , Kimmel Jimmy 
Published: January 2022

In the current research, interdisciplinary approach to Iridium (IV) Oxide (IrO2) nanoparticles as weapons against cancer under synchrotron and synchrocyclotron radiations is investigated. The calculation of thickness and optical constants of Iridium (IV) Oxide (IrO2) interdisciplinary approach to Iridium (IV) Oxide (IrO2) nanoparticles as weapons against cancer under synchrotron and synchrocyclotron radiations produced using solâ€“gel method over glassy medium through a single reflection spectrum is presented. To obtain an appropriate fit for reflection spectrum, the classic Drudeâ€“Lorentz model for parametric diâ€“electric function is used. The best fitting parameters are determined to simulate the reflection spectrum using Lovenbergâ€“Marquardt optimization method. The simulated reflectivity from the derived optical constants and thickness are in good agreement with experimental results.Â Â Â Â Interdisciplinary Approach to Iridium (IV) Oxide (IrO2) Nanoparticles as Weapons Against Cancer Under Synchrotron and Synchrocyclotron Radiations.Â Â Â Â Â Â Â