bluuebunny/crossref_metadata_2025_split huggingface dataset:
Family focused interventions that address parental domestic violence and abuse, mental ill-health, and substance misuse in combination: A systematic review
Authors: Allen Kate , Melendez-Torres G. J. , Ford Tamsin , Bonell Chris , Finning Katie , Fredlund Mary , Gainsbury Alexa , Berry Vashti 
Published: July 2022

Parental domestic violence and abuse (DVA), mental ill-health (MH), and substance misuse (SU) are three public health issues that tend to cluster within families, risking negative impacts for both parents and children. Despite this, service provision for these issues has been historically siloed, increasing the barriers families face to accessing support. Our review aimed to identify family focused interventions that have combined impacts on parental DVA, MH, and/or SU. We searched 10 databases (MEDLINE, PsycINFO, Embase, CINAHL, Education Research Information Centre, Sociological Abstracts, Applied Social Sciences Index & Abstracts, ProQuest Dissertations and Theses Global, Web of Science Core Collection, and Cochrane Central Register of Controlled Trials) from inception to July 2021 for randomised controlled trials examining the effectiveness of family focused, psychosocial, preventive interventions targeting parents/carers at risk of, or experiencing, DVA, MH, and/or SU. Studies were included if they measured impacts on two or more of these issues. The Cochrane Risk of Bias Tool 2 was used to quality appraise studies, which were synthesised narratively, grouped in relation to the combination of DVA, MH, and/or SU outcomes measured. Harvest plots were used to illustrate the findings. Thirty-seven unique studies were identified for inclusion. Of these, none had a combined positive impact on all three outcomes and only one study demonstrated a combined positive impact on two outcomes. We also found studies that had combined adverse, mixed, or singular impacts. Most studies were based in the U.S., targeted mothers, and were rated as ‘some concerns’ or ‘high risk’ of bias. The results highlight the distinct lack of evidence for, and no ‘best bet’, family focused interventions targeting these often-clustered risks. This may, in part, be due to the ways interventions are currently conceptualised or designed to influence the relationships between DVA, MH, and/or SU.
Trial registration: PROSPERO registration: CRD42020210350.
Gene polymorphisms and serum levels of BDNF and CRH in vitiligo patients
Authors: Kussainova Assiya , Kassym Laura , Bekenova Nazira , Akhmetova Almira , Glushkova Natalya , Kussainov Almas , Urazalina Zhanar , Yurkovskaya Oxana , Smail Yerbol , Pak Laura , Semenova Yuliya 
Published: July 2022

Background
Vitiligo is one of the most common hypomelanoses, in which the destruction of functioning melanocytes causes depigmentation of the skin, hair and mucous membranes. The genes encrypting brain-derived neurotrophic factor (BDNF) and corticotropin releasing hormone (CRH) might be the conceivable contributors to the development of vitiligo. This study was aimed at investigation of the serum levels of BDNF and CRH as well as their selected single nucleotide polymorphisms (SNPs) in vitiligo patients in comparison with the healthy controls.

Methods
The cross-sectional study was carried out between October 2020 and June 2021 in 93 vitiligo patients (age range from 23 to 48 years) and 132 healthy controls (age range from 24 to 52 years). The psychological status of study participants was evaluated using the Generalized Anxiety Disorder-7 (GAD-7) scale. Serum levels of BDNF and CRH were measured with the help of a commercially available sandwich enzyme-linked immunosorbent assay (ELISA) kit. Genotyping for the rs11030094 polymorphism of the BDNF gene and for the rs242924 polymorphism of the corticotropin releasing hormone receptor 1 (CRH-R1) gene was performed by a real-time polymerase chain reaction (PCR).

Results
There was a significant relationship between the CRH-R1 rs242924 and BDNF rs11030094 polymorphisms and vitiligo. Moreover, serum levels of neurotransmitters differed significantly between vitiligo and control groups and were associated with the CRH-R1 rs242924 and BDNF rs11030094 SNPs.

Conclusions
Our findings demonstrated the association between CRH-R1 rs242924 and BDNF rs11030094 polymorphisms and vitiligo. Further studies need to be carried out in vitiligo patients to confirm the results observed.
COVID-19 pneumonia: Prediction of patient outcome by CT-based quantitative lung parenchyma analysis combined with laboratory parameters
Authors: Do Thuy D. , Skornitzke Stephan , Merle Uta , Kittel Maximilian , Hofbaur Stefan , Melzig Claudius , Kauczor Hans-Ulrich , Wielpütz Mark O. , Weinheimer Oliver 
Published: July 2022

ObjectivesTo evaluate the prognostic value of fully automatic lung quantification based on spectral computed tomography (CT) and laboratory parameters for combined outcome prediction in COVID-19 pneumonia.MethodsCT images of 53 hospitalized COVID-19 patients including virtual monochromatic reconstructions at 40-140keV were analyzed using a fully automated software system. Quantitative CT (QCT) parameters including mean and percentiles of lung density, fibrosis index (FIBI-700, defined as the percentage of segmented lung voxels ≥-700 HU), quantification of ground-glass opacities and well-aerated lung areas were analyzed. QCT parameters were correlated to laboratory and patient outcome parameters (hospitalization, days on intensive care unit, invasive and non-invasive ventilation).ResultsBest correlations were found for laboratory parameters LDH (r = 0.54), CRP (r = 0.49), Procalcitonin (r = 0.37) and partial pressure of oxygen (r = 0.35) with the QCT parameter 75thpercentile of lung density. LDH, Procalcitonin, 75thpercentile of lung density and FIBI-700were the strongest independent predictors of patients’ outcome in terms of days of invasive ventilation. The combination of LDH and Procalcitonin with either 75thpercentile of lung density or FIBI-700achieved a r2of 0.84 and 1.0 as well as an area under the receiver operating characteristic curve (AUC) of 0.99 and 1.0 for the prediction of the need of invasive ventilation.ConclusionsQCT parameters in combination with laboratory parameters could deliver a feasible prognostic tool for the prediction of invasive ventilation in patients with COVID-19 pneumonia.
Viraemic-time predicts mortality among people living with HIV on second-line antiretroviral treatment in Myanmar: A retrospective cohort study
Authors: Mesic Anita , Decroo Tom , Mar Htay Thet , Jacobs Bart K. M. , Thandar Moe Pyae , Thwe Thin Thin , Kyaw Aung Aung , Sangma Mitchell , Beversluis David , Bermudez-Aza Elkin , Spina Alexander , Aung Darli Po Po , Piriou Erwan , Ritmeijer Koert , Van Olmen Josefien , Oo Htun Nyunt , Lynen Lutgarde 
Published: July 2022

Introduction
Despite HIV viral load (VL) monitoring being serial, most studies use a cross-sectional design to evaluate the virological status of a cohort. The objective of our study was to use a simplified approach to calculate viraemic-time: the proportion of follow-up time with unsuppressed VL above the limit of detection. We estimated risk factors for higher viraemic-time and whether viraemic-time predicted mortality in a second-line antiretroviral treatment (ART) cohort in Myanmar.

Methods
We conducted a retrospective cohort analysis of people living with HIV (PLHIV) who received second-line ART for a period >6 months and who had at least two HIV VL test results between 01 January 2014 and 30 April 2018. Fractional logistic regression assessed risk factors for having higher viraemic-time and Cox proportional hazards regression assessed the association between viraemic-time and mortality. Kaplan-Meier curves were plotted to illustrate survival probability for different viraemic-time categories.

Results
Among 1,352 participants, 815 (60.3%) never experienced viraemia, and 172 (12.7%), 214 (15.8%), and 80 (5.9%) participants were viraemic <20%, 20–49%, and 50–79% of their total follow-up time, respectively. Few (71; 5.3%) participants were ≥80% of their total follow-up time viraemic. The odds for having higher viraemic-time were higher among people with a history of injecting drug use (aOR 2.01, 95% CI 1.30–3.10, p = 0.002), sex workers (aOR 2.10, 95% CI 1.11–4.00, p = 0.02) and patients treated with lopinavir/ritonavir (vs. atazanavir; aOR 1.53, 95% CI 1.12–2.10, p = 0.008). Viraemic-time was strongly associated with mortality hazard among those with 50–79% and ≥80% viraemic-time (aHR 2.92, 95% CI 1.21–7.10, p = 0.02 and aHR 2.71, 95% CI 1.22–6.01, p = 0.01). This association was not observed in those with viraemic-time <50%.

Conclusions
Key populations were at risk for having a higher viraemic-time on second-line ART. Viraemic-time predicts clinical outcomes. Differentiated services should target subgroups at risk for a higher viraemic-time to control both HIV transmission and mortality.
Efficacy and safety of ruxolitinib for steroid-refractory graft-versus-host disease: Systematic review and meta-analysis of randomised and non-randomised studies
Authors: Zhang Meng-yun , Zhao Peng , Zhang Yan , Wang Ji-shi 
Published: July 2022

Background
Hematopoietic stem cell transplantation (HSCT) for haematological disorders. Graft-versus-host disease (GVHD), a cause of morbidity and mortality is treated with corticosteroids. However, patients with steroid-refractory GVHD after HSCT have a poor prognosis. Ruxolitinib, a selective Janus kinase inhibitor, is a novel treatment strategy for steroid-refractory GVHD.

Objectives
To assess the efficacy of ruxolitinib for the treatment of steroid-refractory GVHD and analyse its adverse effects.

Study design
Meta-analysis.

Search methods
Randomised controlled trials (RCTs) and non-RCTs of ruxolitinib-based therapy in patients with steroid-refractory GVHD were found in the Cochrane Central Register of Controlled Trials, EMBASE, PubMed, and Web of Science in March 2021. Outcomes included overall response rate, survival, and adverse effects. The Methodological Index for Non-randomised Studies (MINORS) and the Cochrane collaboration risk-of-bias tool were used to assess methodological quality. Funnel plots, Egger’s test, and the trim and fill method were used to assess publication bias.

Results
In total, 1470 studies were identified; 19 studies (17 non-RCTs, 2 RCTs) involving 1358 patients met our inclusion criteria. Survival rates at the longest follow-up in non-RCTs, were 57.5% (95% CI 46.9–67.4) and 80.3% (95% CI 69.7–87.9) for acute GVHD (aGVHD) and chronic GVHD (cGVHD), respectively. In non-RCTs, the overall response was 74.9% (95% CI 66.6–81.8, I2 = 49%) in aGVHD and 73.1% (95% CI 62.5–81.6, I2 = 49%) in cGVHD. In aGVHD, the response rates were gastrointestinal, 61.4–90.2%; skin, 52.5–80.6%; and liver, 41.8–71.8%. In cGVHD, the response rates were gastrointestinal, 30.1–70.4%; skin, 30.1–84.4%; lung, 27.0–83.0%; and mouth 3.5–98.1%. In addition, a lower aGVHD grade and moderate cGVHD were associated with a better clinical response. Common adverse events were cytopenia and infectious complications.

Conclusions
Our systematic review and meta-analysis indicated that ruxolitinib therapy could be a potentially effective and safe treatment for patients with steroid-refractory GVHD.
Defensa y protección de la honra femenina a finales del virreinato novohispano: dos instituciones de caridad
Authors: Hernández-Torres Yolopattli 
Published: July 2022

ResumenEste ensayo analiza cómo la práctica de la sexualidad extramatrimonial fue determinante para crear instituciones que protegieran la honra femenina como la Casa de Niños Expósitos o la Sala de Partos Ocultos en la Ciudad de México. Estas instituciones resguardaban, más que a las mujeres, a la sociedad de atestiguar actitudes consideradas indeseables. Ambos lugares encarnan la alianza de sistemas religiosos, legales y médicos que ocultaban el resultado de prácticas sexuales furtivas. Este artículo contrasta los libros de estas instituciones con querellas donde las mujeres filtraban sus voces a través del escribano y los recados dejados con los niños expósitos.
Sobre un desfamiliarizado juego cubano: cine deportivo e infelicidadqueerenLa partida(2013)
Authors: Isea Antonio 
Published: July 2022

ResumenLa partida, segundo largometraje del cineasta español Antonio Hens, ofrece un relato que aúna fútbol y deseo erótico entre atletas varones en la Cuba del siglo xxi. En una nación que presume de ser beisbolera y extremadamente heteropatriarcal, este filme es una producción cultural que destacó por romper con la ortodoxia del cine deportivo cubano. Este trabajo analiza la identidad de género textual (genre) en La partida y sugiere que este rasgo del filme consigue crear una obra reivindicadora de lo que Sara Ahmed y Heather Love, respectivamente, han llamado infelicidad queer.
Transcrição e anotação de dados linguísticos usando as ferramentas ELAN e LancsBox
Authors: Sousa Marta Deysiane Alves Faria , Souza Victor Renê Andrade 
Published: July 2022

Objetiva-se com este trabalho demonstrar como as ferramentas de transcrição de dados ELAN 5.9 (2020) e de análise de corpora LancsBox 5.1.2 (BREZINA; WEILL-TESSIER; MCENERY, 2020) têm contribuído para a transcrição de entrevistas sociolinguísticas realizadas no escopo do Grupo de Estudos em Linguagem, Interação e Sociedade (GELINS) da Universidade Federal de Sergipe, bem como para extração automatizada de fenômenos linguísticos variáveis. Para tanto, apresenta-se as normas pelas quais as entrevistas são transcritas, formas de utilizar o ELAN 5.9 (2020) para transcrição, e por fim, a maneira de fazer a etiquetagem morfológica dos dados e buscas por fenômenos variáveis nos dados de fala utilizando-se a ferramenta LancsBox 5.1.2 (BREZINA; WEILL-TESSIER; MCENERY, 2020). As duas ferramentas têm se mostrado eficientes para uma transcrição alinhada com áudio, para anotação morfológica e buscas automáticas em grandes volumes de textos orais. Este texto contribui para exploração de ferramentas que permitam uma transcrição mais rápida e acurada de dados orais bem como buscas mais automatizadas de grandes volumes de dados.
Percepciones de los emprendedores sobre la calidad del servicio de Punto De Retiro (PDR)
Authors: Corbalan Parada Victoria Agostina , Koch Emiliano , Cuozzo Mauricio 
Published: July 2022

Este informe trata sobre la percepción de los emprendedores respecto de la calidad del servicio de la empresa «Punto de retiro (PDR)». El presente trabajo tiene un enfoque mixto, bajo un diseño explicativo secuencial (DEXPLIS) con el fin de obtener una perspectiva más amplia y profunda del fenómeno. Se utiliza la herramienta SERVPERF que mide la calidad del servicio, mediante las percepciones de los clientes, en base a cincodimensiones. Como instrumento de recolección de datos empleado para el enfoque cuantitativo se recurrió a la aplicación de una encuesta dirigida a los emprendedores que contratan el servicio de PDR y a los dueños de la empresa. También se toma el enfoque cualitativo con el propósito de examinar la forma en que los emprendedores y los dueños perciben y experimentan el fenómeno bajo estudio, se recolectanestos datos mediante entrevista y focus group, para así poder auxiliar la interpretación y explicación de los descubrimientos cuantitativos iniciales y la relación que existe entre ellos.Los resultados esperados pretenden comparar las perspectivas de los emprendedores y los dueños con el fin de entender los aspectos a mejorar en la calidad del servicio de PDR.
Analysis of Wake Turbulence for a Savonius Turbine for Malaysia’s Slow-Moving Current Flow
Authors: Rahman Anas Abdul , Rajendran Kumaran , Abdul-Rahman Ayu , Suhri Gisrina Elin , Dass Lakshuman 
Published: July 2022

With Malaysia being surrounded by water bodies, tidal energy could be used for energy extraction. While several turbine designs and technologies have been used for tidal energy extraction, information on the use of vertical-axis tidal turbines (VATTs) for shallow-water applications is scarce. However, implementing horizontal-axis tidal turbines (HATTs) is not feasible due to Malaysian ocean depths. Hence, examining the wake-flow characteristics of VATTs in a shallow water-working environment in Malaysia is essential. The wake turbulence of the Savonius turbine model was compared with that of a hypothetical ‘actuator' cylinder, a VATT representation. Subsequently, the wake turbulences of a Savonius turbine model in static and dynamic simulations were compared to understand the flow distinction. Compared with that exhibited by the hypothetical actuator cylinder of 2.5 m, the hypothetical actuator cylinder of 5 m exhibits greater velocity deceleration. Additionally, the modelled Savonius turbine exhibits significantly more deceleration than that exhibited by the hypothetical actuator cylinder. Finally, the analysis of the static model of the Savonius turbine shows deceleration that is greater than that of the dynamic model.
Influence of the Field of View on Shear Wave Velocity Estimation
Authors: Grube Sarah , Neidhardt Maximilian , Latus Sarah , Schlaefer Alexander 
Published: July 2022

Abstract
Tissue elasticity contains important information for physicians in diagnosis and treatment, and, e.g., can help in tumor detection because tumors are stiffer than healthy tissue. Ultrasound shear wave elastography imaging (US-SWEI) can be used to estimate tissue stiffness by measuring the velocity of induced shear waves. Commonly, a linear US probe is used to track shear waves at a high imaging frequency in 2D. Realtime US-SWEI is limited by the required time for data processing. Hence, reducing the imaging field of view (FOV) is beneficial as it decreases the size of the acquired data and thereby the acquisition, transfer and processing time. However, a decrease in the FOV has the disadvantage that shear waves are tracked over a smaller distance and thus, also fewer sampling points are available for velocity estimation. This trade-off between a smaller FOV and thus, a smaller data size, and the accuracy of shear wave velocity estimation is investigated in this work. For this purpose, shear waves were tracked with a linear US probe in gelatin phantoms with four different stiffness values. During data processing, we reduced the FOV virtually from 38.1mm to 2.1mm. It was found that a reduction of the FOV to 4.5mm leads to an overestimation of up to five times larger shear wave velocities but still allows to distinguish between phantoms of different stiffness. However, not all estimated velocity values could be clearly assigned to the correct stiffness value. The smallest studied FOV of 2.1mm was not sufficient for distinguishing between the phantoms anymore.
Robotic Sensorized Gastroendoscopy with Wireless Single-Hand Control
Authors: García Gabriela , Fischer Nikola , Marzi Christian , Mathis-Ullrich Franziska 
Published: July 2022

Abstract
The manipulation of flexible endoscopes is a procedure that requires great dexterity since it requires the synchronization and use of both hands in parallel. Imprecise handling during gastroendoscopy could harm the digestive tract. Our solution allows the physician to use only one hand to wirelessly control the forward, backward, and tip bending motion. The proposed system provides endoscopic vision and tactile impact force sensing at the tip to detect the force applied to tissue and thus avoid damage. We experimentally evaluate the handling of the robotic system in open space and inside a medical phantom. The results revealed a training effect with less time demand for task completion and reduction of average impact force after only 5 runs. The proposed system was successfully controlled using one hand and, together with the force information, could enhance the physician’s experience during endoscopy. Future work will address axial control and an intensive user study with clinical experts.
Hybrid Offspring of C57BL/6J Mice Exhibit Improved Properties for Neurobehavioral Research
Authors: Sloin Hadas E. , Bikovski Lior , Levi Amir , Amber-Vitos Ortal , Katz Tomer , Spivak Lidor , Someck Shirly , Gattegno Roni , Sivroni Shir , Sjulson Lucas , Stark Eran 
Published: July 2022

AbstractC57BL/6 is the most commonly used mouse strain in neurobehavioral research, serving as a background for multiple transgenic lines. However, C57BL/6 exhibit behavioral and sensorimotor disadvantages that worsen with age. We bred FVB/NJ females and C57BL/6J males to generate first-generation hybrid offspring (FVB/NJ x C57BL/6J)F1. The hybrid mice exhibit reduced anxiety-like behavior, improved learning, and enhanced long-term spatial memory. In contrast to both progenitors, hybrids maintain sensorimotor performance upon aging and exhibit improved long-term memory. The hybrids are larger than C57BL/6J, exhibiting enhanced running behavior on a linear track during freely-moving electrophysiological recordings. Hybrids exhibit typical rate and phase coding of space by CA1 pyramidal cells. Hybrids generated by crossing FVB/NJ females with transgenic males of a C57BL/6 background support optogenetic neuronal control in neocortex and hippocampus. The hybrid mice provide an improved model for neurobehavioral studies combining complex behavior, electrophysiology, and genetic tools readily available in C57BL/6 mice.
Science disinformation as a security threat and the role of science communication in the disinformation society
Authors: Falyuna Nóra 
Published: July 2022

Summary. The danger of the spread of science disinformation was
demonstrated by the coronavirus pandemic. This created a complex crisis,
affecting economic, social, and public health security, so disinformation can be
perceived as a security threat. Understanding characteristics, communication,
and mechanisms of disinformation are particularly important. In this paper, I
will elaborate on the concept of disinformation society based on the information
society and the dangers of science disinformation, mainly using the example of
the disinformation wave that accompanied the coronavirus epidemic. I present the
main responses to the problem, highlighting the role of science communication. I
will emphasize the need to change attitudes in science communication practices
and show how understanding science disinformation can help to do this.
Összefoglalás. Az új kommunikációs és médiakörnyezet újítólag hat a
dezinformáció megjelenésének és terjedésének módjára, formáira, a terjesztő
aktorok számára, az alkalmazott új információmanipulációs technológiára és e
tartalmak társadalmi hatásaira. Az információs társadalom koncepciójára
reagálva, egyes szakértők már inkább dezinformációs társadalomról beszélnek. A
dezinformáció, különösen a tudományos dezinformáció jelentőségét és terjedésének
veszélyét a pandémia mutatta meg igazán, amely során a dezinformáció különböző
formái, kiemelten az áltudományos és tudományellenes elméletek mennyisége,
terjedésük sebessége és hálózatba szerveződése példátlan volt. A tudományos
dezinformáció komoly veszélyt jelenthet akár az egyénre, a szélesebb
közösségekre, vagy akár a társadalom egészére nézve is. Napjainkban a
dezinformáció megjelenik a biztonságot, jelesül az információbiztonságot
fenyegető veszélyek között is. A világjárvány komplex válsághelyzetet szült,
amely a gazdasági, társadalmi és közegészségügyi biztonságot is meghatározza,
ezért a dezinformáció felfogható nemzetbiztonsági fenyegetésként is. A
tudományos dezinformáció működésének, kommunikációjának, hatásmechanizmusának
megértése így különösen fontos, mivel közvetlenül biztonságot fenyegető
tényezővé válhat. A tanulmányban bemutatom, hogyan épül az információs
társadalom alapjaira a dezinformációs társadalom koncepciója, külön kiemelve a
tudományos dezinformáció működését, hálózatosodását és veszélyeit, elsősorban a
koronavírus köré épülő infodémia példáján. Ezután a problémára adható főbb
válaszreakciókat tárgyalom, kiemelve a tudománykommunikáció szerepét. Amellett
érvelek, hogy olyan tudománykommunikációs fejlesztésre van szükség, amely
elsősorban nem a közösségimédia-platformok használatát, hanem a
tudománykommunikációs gyakorlatok során megmutatkozó szemlélet változását
helyezi fókuszba. Végül bemutatom, hogy ehhez a szemléletváltáshoz milyen
támpontokat nyújthat a tudományos dezinformáció jellemzőinek vizsgálata.