bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factores determinantes de la utilización de instrumentos públicos para la gestión del riesgo en la industria vitivinícola chilena: un modelo logit binomial
Authors: Lobos Germán , Viviani Jean-Laurent 
Published: December 2022

El objetivo principal de esta investigación fue identificar los factores determinantes de la utilización de instrumentos públicos en la industria vitivinícola chilena. Se planteó un modelo de regresión logística (logit) binomial. Entre enero y octubre de 2007 se aplicó un cuestionario y se construyó una base de datos con una muestra que incluyó 104 empresas vitivinícolas. El ajuste del modelo fue realizado mediante Máxima Verosimilitud usando SPSS v 15.0. Las variables que resultaron significativas fueron el riesgo de precio de vino, disponibilidad de asesoría externa, y número de trabajadores permanentes. Desde el punto de vista de la gestión pública la principal conclusión sugiere que se podría incrementar el uso de instrumentos públicos si los vitivinicultores contaran con más asesoría externa. Palabras clave: industria vitivinícola, regresión logística, máxima verosimilitud, gestión pública. Clasificación JEL: C13, C35, H3. Abstract: The main objective of this research was to identify the determining factors of the use of public instruments to manage risk in the Chilean wine industry. A binomial logistic regression model was proposed. Based on a survey of 104 viticulture and winemaking companies, a database was constructed between January and October 2007. The model was fitted using maximum likelihood estimation. The variables that turned out to be statistically significant were: risk of the wine price, availability of external consultancy and number of permanent workers. From the Public Management point of view, the main conclusion suggests that the use of public instruments could be increased if viticulturists and winemakers had more external counseling. Keywords: wine industry, logistic regression, maximum likelihood, public management. JEL Classification: C13, C35, H3. Résumé : L.objectif principal de cette étude était d.identifier les facteurs déterminants de l.utilisation d.instruments publics pour la gestion des risques dans l.industrie vitivinicole chilienne. Un modèle de régression logistique binomiale a été proposé. À partir d.un questionnaire appliqué entre janvier et octobre 2007, une base de données a été construite avec un échantillon qu.incluaient 104 entreprises vitivinicoles. L.ajustement du modèle a été fait au moyen de la technique de vraisemblance maximale utilisant le logiciel SPSS v. 15.0. Les variables qui sont apparues comme statistiquement significatives ont été : risque du prix du vin, disponibilité de conseil externe et nombre de travailleurs permanents. Du point de vue de la gestion publique, la conclusion principale suggère que l.utilisation d.instruments publics pourrait s.accroître si les producteurs vitivinicoles disposaient de plus de conseil externe. Mots-clés : industrie vitivinicole, régression logistique, vraisemblance maximale, gestion publique. Classification JEL: C13, C35, H3.
Efectos de las técnicas de filtrado en la evaluación de un modelo de ciclos económicos reales
Authors: Vásquez Bedoya Fredy , Restrepo Ochoa Sergio 
Published: December 2022

Este trabajo emplea el filtro de Hodrick y Prescott (HP), el filtro Paso de Banda (PB) y una descomposición teórica (DT), para mostrar cómo las regularidades cíclicas caracterizadas por el modelo de crecimiento exógeno de King, Plosser y Rebelo (1988) dependen de la técnica de filtrado empleada. Este artículo exhibe diferencias estadísticamente significativas entre propiedades de los componentes cíclicos aislados con los filtros HP, PB y DT; en particular entre los filtros HP y PB, lo cual difiere de los resultados de Canova (1998). También se evidencia que el método de filtrado DT no es consistente con la definición del cíclico económico dada por la National Bureau of Economic Research (NBER). Palabras Clave: Modelo de crecimiento neoclásico básico, técnicas de filtrado, contrastes estadísticos, análisis en el dominio de la frecuencia. Clasificación JEL: C14, C15, E32 Abstract: This work uses the Hodrick and Prescott filter (HP), the Band-Pass filter (BP), and a theoretical decomposition (TD), to show how the cyclical regularities characterized by the model of exogenous growth of King, Plosser and Rebelo (1988) depend on the filter technique used. This article exhibits statistically significant differences between properties of the cyclical components isolated with the HP, BP and TD filters; in particular between the HP and BP filters, which differs from the results of Canova (1998). It also shows that the TD filter technique is not consistent with the definition of economic cycle given by the National Bureau of Economic Research (NBER). Key words: Basic Neoclassical Growth Model, Detrending Methods, Statistical Tests, Frequencydomain Analysis. JEL Classification: C14, C15, E32. Résumé: Ce travail utilise le filtre Hodrick-Prescott (CV), le filtre passe bande (PB) et une décomposition théorique (DT) pour montrer comment les régularités cycliques du modèle de croissance exogène de King, Plosser et Rebelle (1988) dépendent de la technique de filtration employée. Cet article montre les différences statistiquement significatives existantes dans les propriétés de composantes cycliques isolées avec les filtres CV, PB et DT. Tout particulièrementnous soulignons les différences entre les filtres CV et PB, dont les résultats diffèrent de ceux présentés par Canova (1998). On démontre également que la méthode de filtration DT n'est pas consistante avec la définition de cyclique économique proposée par le National Bureau of Economic Research (NBER). Mots Clé: Modèle néo-classique de croissance, techniques de filtration, contrastes statistiques, dominance de la fréquence. Classification JEL : C14, C15, E32
Una evaluación de las políticas promocionales de inversión extranjera directa en América Latina
Authors: Morales Lorena , Guerrero Oriana Patricia , López Mauricio 
Published: December 2022

En las últimas dos décadas la Inversión Extranjera Directa (IED) ha ganado importancia en las diferentes economías de América Latina. En este artículo se pretende mostrar que esta importancia se debe a la mayor estabilidad macroeconómica y la liberalización y flexibilización de los marcos regulatorios de los países de la región. Así, este artículo, mediante un modelo de datos de panel, encontró que las medidas implementadas para atraer IED en América Latina han presentado un impacto positivo, porque permiten el mayor ingreso de recursos. De otro lado, el modelo también permite constatar la importancia de otros factores como la estabilidad macroeconómica y el tamaño del mercado, los cuales también explican un buen porcentaje de estos flujos. Palabras claves: Inversión Extranjera Directa, estabilidad macroeconómica, marco regulatorio, políticas promocionales. Clasificación JEL: F21, F23, F40. Abstract: In the past two decades, Foreign Direct Investment (FDI) has gained importance in Latin American economies. This is because, as this article intends to demonstrate, increasingly sounder macro-economic stability and the fact that the region's countries have opened and flexibilized their regulatory frameworks. In this manner, and through a model of data from panels, this article finds that the measures implemented in Latin America to attract FDI have enabled a larger inflow of resources. On another front, the model also ascertains the importance of other factors such as macroeconomic stability and the size of the market, which also explain a good percentage of these flows. Keywords: Foreign Direct Investment, Macro-economic Stability, Regulatory Frameworks, Promotional Policies. JEL Classification: F21, F23, F40. Résumé : Dans les deux dernières décennies l'Investissement Étranger Direct (IED) a gagné du terrain en Amérique latine. Dans cet article nous montrons que ce regain dans les niveaux de l'IED est dû à la plus grande stabilité macro-économique, à la libéralisation et à l'assouplissement de la régulation économique des pays. À travers modèle de données de panneau nous montrons, d'une part, que les politiques économique mises en oeuvre pour attirer l'IED en Amérique latine ont eu un impact positif sur les économies car elles permettent l'entrée d'une plus grande quantité de ressources. D'un autre parte, le modèle permet aussi de constater les niveaux d''importance d'autres facteurs comme la stabilité macro-économique et la taille du marché, lesquels expliquent un pourcentage assez considérables de l'IED. Mots clé: Investissement étranger direct, stabilité macro-économique, régulation, politiques promotionnelles. Classification JEL : F21, F23, F40.
In Search of a Definition For the History of Economic Thought
Authors: Gómez Rebeca , Tobón Alexander 
Published: December 2022

Esta nota discute algunas ideas sobre el carácter, el método y la identidad del historiador del pensamiento económico, quien se define como un economista "generalista" cuya característica principal es su conocimiento de las teorías económicas generales. Las teorías generales permiten, por una parte, establecer un vínculo con las distintas especialidades económicas y, por otra parte, permiten reconciliarse con la economía contemporánea. De esta manera, el historiador del pensamiento económico ocupa un lugar preciso y permanente dentro de la economía. Palabras claves: historia del pensamiento económico, historia de la economía, método de la economía, teorías económicas generales, economista. Clasificación JEL: A11, B10, B20 Abstract: This note discusses some ideas in regards to the character, method, and identity of historians of economic thought. They may be considered “generalist” economists, who hold knowledge of general theories. This knowledge allows them to establish links between different fields of specialization in economic, and the reconciliation with the contemporary economics. Therefore, historians of economic thought have a precise and permanent position within the economicsdiscipline. Keywords: History of Economic Thought, History of Sciences, Economic Methodology, Economic Theory, Economist. Classification JEL: A11, B10, B20 Résumé: Cette note analyse quelques idées concernant le caractère, la méthode et l'identité de l'historien de la pensée économique, lequel est définie comme un économiste "généraliste" ; dont sa caractéristique principale est sa connaissance des théories économiques générales. Celles-ci permettent, d'une part, d'établir un lien avec les différentes spécialités en économie et, d'autre part, elles permettent de se réconcilier avec l'économie contemporaine. De cette manière, l'historien de la pensée économique occupe une place précise et permanente dans l'économie. Mots clé: histoire de la pensée économique, histoire de l'économie, méthode de l'économie, théories économiques générales, économiste. Classification JEL : A11, B10, B20
Evaluation of the physicochemical, physical and sensory properties of fresh cape gooseberry and vacuum impregnated with physiologically active components
Authors: PEÑA C. Ruth F. , CORTÉS RODRÍGUEZ Misael , MONTOYA CAMPUZANO Olga Inés 
Published: December 2022

Background: Functional Foods are considered nowadays by consumers as the range of foods of major interest. Objectives: The aim of the present work was the evaluation of color, texture and sensorial properties of fresh Cape Gooseberry (FG) and vacuum impregnated Cape Gooseberry (IG) with calcium and vitamins B9, C, D and E during storage at 4ºC. Methods: Entire cape gooseberries were vacuum impregnated (VI) with tocopherol and cholecalciferol emulsified in aqueous phase with sucrose, ascorbic acid, folic acid, calcium chloride, calcium fumarate, low methoxyl pectin, isolated soy protein, tensoactives and preservatives. The texture was determined from puncture assays, and the color from the CIE Lab coordinates. The sensorial profile was determined with the aid of trained panelists, through a multidimensional approach of characteristic descriptors of general appearance, odor, taste and texture. Results: The instrumental values of color and texture for IG were significantly different from the FG, because are being softer, more elastic, darker, brighter and of less color saturation. The samples of FG and IG presented intense sensorial characteristics in the descriptors orange color, brightness, spherical uniformity, smooth surface, fresh appearance, odor, cape gooseberry characteristic taste and frutal, fleshy texture, juicy, firmness and turgidity. By the effect of VI process the most relevant significant differences were the descriptors orange color, superficial stains, fresh appearance, sweet taste and cape gooseberry characteristic taste, soft texture, firmness and juicy; whereas for the effect of storage time were fresh appearance, dehydrated appearance, peduncle cicatrization, aromatic odor, overripe, cape gooseberry characteristic taste, frutal taste, soft texture, juicy, firmness and turgidity. Conclusions: The VI significantly affects the objective
assessment of color and texture, finding correspondence with the sensorial evaluation; nonetheless, the general quality of the FG presented a greater score than those presented by IG.
Efectividad y seguridad del esquema genérico lamivudina/zidovudina/efavirenz en pacientes VIH (+). Estudio fase IV y comparación con el mismo esquema de medicamentos innovadores
Authors: GUTIÉRREZ HENAO Francisco Javier , AMARILES Pedro , GALINDO QUINTERO Jaime , MUESES MARÍN Hector Fabio , AGUDELO A. Juan Fernando , HINCAPIE GARCÍA Jaime Alejandro 
Published: December 2022

Antecedentes: El fortalecimiento de la política de productos competidores (genéricos) se puede acompañar de interrogantes sobre la calidad y, por tanto, sobre la efectividad de algunos de estos medicamentos. Los estudios fase IV son una opción válida para valorar la efectividad y seguridad de estos medicamentos. Objetivos: Valorar la efectividad y seguridad del esquema genérico Lamivudina/Zidovudina/Efavirenz en pacientes con VIH/SIDA que no han recibido terapia antirretroviral, que son atendidos en un programa de atención integral ambulatoria especializada, y comparar estos resultados con los datos de eficacia y seguridad reportados en un estudio de referencia (que utiliza el mismo esquema de medicamentos innovadores y fue realizado con pacientes con condiciones similares). Métodos: Se realizó un estudio clínico abierto no controlado del tipo fase IV. Se valoró la efectividad (disminución de carga viral en plasma y aumento de linfocitos CD4+) y seguridad (reacciones adversas) del esquema genérico Lamivudina/Zidovudina/Efavirenz durante 12 meses en pacientes mayores de 18 años VIH (+), que no habían recibido terapia antirretroviral y con indicación para recibirla. Los seguimientos clínicos y el seguimiento farmacoterapéutico fueron utilizados como estrategias de valoración y recolección de datos. Los resultados fueron comparados con los resultados reportados en un estudio referencia, contrastando la hipótesis de no inferioridad de dichos resultados. Resultados: El estudio incluyó 47 pacientes, de los cuales 33 estuvieron presentes hasta el final del estudio. Al año de tratamiento, en 28 pacientes (el 85%) la carga viral (valorada por indetectabilidad de las copias de RNAm viral/mL) alcanzó una disminución estadísticamente significativa, mientras que en 30 pacientes (el 91%) el recuento de linfocitos T-CD4+ mayor
a 200 células/mm3 alcanzó un aumento progresivo y estadísticamente significativo. Para la comparación se halló un artículo que cumplió con los criterios definidos y se contrastó la hipótesis de no inferioridad. En comparación con el estudio referencia, las proporciones de pacientes [intervalo de confianza del 95%] que lograron indetectabilidad no fueron estadísticamente diferentes: 0,85 [0,69-0,93] versus 0,90 [0,81-0,93], p = 0,7; similarmente, no se encontró diferencias en el incremento promedio [desviación estándar] de linfocitos CD4+: 179 [142] versus 201 [21], p = 0,08. Tampoco se encontró diferencias notorias en el perfil de seguridad. Conclusiones: El esquema genérico evaluado, Lamivudina/Zidovudina/Efavirenz,
muestra resultados de efectividad no inferiores a los reportados en un estudio de referencia diseñado para valorar el mismo esquema de medicamentos innovadores.
Experience of Nusinersen in children with proximal spinal muscular atrophy 5q in Moscow region
Authors: Panteleeva M. V. 
Published: December 2022

Background. Proximal spinal muscular atrophy 5q (5q-SMA) is a severe autosomal recessive neuromuscular disorder characterized by progressive flaccid paralysis and muscular atrophy caused by degeneration of α-motor neurons in the anterior horns of the spinal cord resulted from mutations in the SMN1 gene encoding the survival motor neuron (SMN) protein. These patients have pronounced limitations of motor activity and their life expectancy is between several weeks and several decades. The development and implementation of causal therapy improved the quality of life and increased life expectancy of SMA patients. Nusinersen is one of the first drugs approved for SMA in the Russian Federation. It is an antisense oligonucleotide drug that increases the production of full-length SMN protein.Aim. To confirm the efficacy and safety of Nusinersen in children with type I–III SMA from Moscow region.Materials and methods. A total of 22 patients with type I–III SMA have been receiving Nusinersen since 2020. Treatment outcomes were evaluated using the Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND) in children with type I SMA and Hammersmith Functional Motor Scale Expanded (HFMSE) in children with type II–III SMA.Results. All patients completed the stage of loading doses, including 1 patient treated for 5 years (18 injections), 3 patients treated for 3 years (12 injections), 10 patients treated for 2 years (9 injections), 4 patients treated for more than 1 year (6 injections), and 4 patients treated for less than 1 year (5 injections). Patients with type I SMA demonstrated increased scores after one year of therapy. Patients with type I–III SMA also had some improvement and higher HFMSE after loading doses followed by positive dynamics after 2 and 3 years of therapy.This article also contains cases that confirm the need of early treatment initiation immediately after the diagnosis.Conclusions. We corroborated the efficacy and safety of Nusinersen in routine clinical practice for children with different types of SMA.
Congenital cerebral palsy with epilepsy: clinical and genetic comparisons
Authors: Chebanenko N. V. , Sokol P. L. , Prityko A. G. 
Published: December 2022

Background. The problem of congenital cerebral palsy (CP) is relevant due to the limited complexity of habilitation and social adaptation of such patients. The genetic aspects of the pathogenesis of the disease are being actively studied. CP is often accompanied by epilepsy, which is characterized by refractoriness.Aim. To analyze the clinical, genetic and neuroimaging aspects of this pathology in CP patients.Materials and methods. The study included 136 patients with CP. Genetic studies were carried out on venous blood material using NGS and Sanger trio methods. The distribution of genes into groups of determinants was carried out.Results. In 136 patients, 91 genes with pathogenic variants were found. There were more of them in the determinant groups CS (regulation of cytoskeleton formation and functioning), ENM (regulation of neuronal membrane excitability), CMTR (control of chromatin modifications, transcription and replication processes), NTS (regulation of neurotransmitter metabolism and synapse functioning). The distribution of genes according to the degree of motor deficiency was specific: in all groups, except for canalopathy genes (ENM): certain genes corresponded to each degree of motor deficiency. This specificity was less pronounced in the ENM group. The largest number of cases of abnormalities in the structure of the brain was in the CMTR (control of chromatin modifications, transcription and replication processes), CS (regulation of the formation and functioning of the cytoskeleton) and ENM (regulation of the excitability of the neuronal membrane) groups. The RMF group (regulation of the functions of the mitochondrial apparatus) was characterized by the highest resistance to epilepsy. In cases from the group with the canalopathy genes (ENM), the epileptic process was not the most refractory.Conclusions. According to the contribution to the pathogenesis of CP with epilepsy, the distribution of determinants for the provision of excitability and conduction of the nervous tissue (ENM and NTS), the regulation of neuroontogenesis processes (NOG and CMTR), and the predetermination of enzymatic defects leading to storage diseases (GSD) are permissible. The determinant ENM is responsible for both the formation of motor deficits and the formation of the epileptic process. At the same time, its influence on motor deficit is nonspecific, and the degree of refractoriness of the epileptic process largely determines the determinant of mitochondrial function regulation.
ACADEMIC STAFF DEVELOPMENT AS AN ENABLER TO GOOD TEACHING PRACTICES AT A HIGHER EDUCATION INSTITUTION IN THE EASTERN CAPE, SOUTH AFRICA
Authors: Baleni Zwelijongile Gaylard , Buka Andrea Mqondisi , Ndebele Clever 
Published: December 2022

Higher Education (HE) institutions have to provide support to Academic Staff Development (ASD) through policies, funding and strategies that afford lecturers opportunities to attend ASD disciplinary-based and professional training. Upgrading the nature of teaching and learning is a key strategy in HE and that responsibility lies with Higher Education institutions that identify with the innovative nature of teaching and learning. Good teaching is not an accident, it is achieved through continuous engagement and enhancement of lecturers on both content and innovative pedagogical skills. Such skills need to be horned continuously to close gap in lecturers’ gap and Pedagogical Content Knowledge (PCK) suits that approach. This study was grounded on principles of Pedagogical Content Knowledge (PCK). It was conducted in one university campus comprising of two sites in the Eastern Cape in South Africa. A purposive sample of 51 academics was used for data collection. Content analysis was used to identify emerging themes from the interview responses. The findings showed that lecturers regard ASD as enhancing quality teaching and empowering lecturers to improve their lecturing skills and responsibilities.