bluuebunny/crossref_metadata_2025_split huggingface dataset:
A brief history of special education policy on the inclusion of students with intellectual disabilities in Saudi Arabia
Authors: Abu‐Alghayth Khalid M. , Catania Nicholas , Semon Sarah , Lane Danielle , Cranston‐Gingras Ann 
Published: March 2022

AbstractBackgroundThe demand for educational and social inclusion of children with intellectual disabilities continues to grow throughout the world. Factors contributing to the increasing demand include family advocacy efforts, shifting views about the nature of disability, and increased international recognition of the rights of children with disabilities. In the 1970s, Saudi Arabia began investing in educational services and supports for students with disabilities in both segregated and mainstream education settings.MethodsPolicies for children with intellectual disabilities were identified and analysed using the disability policy analysis model recommended by Turnbull & Stowe (2014). Then in two subsequent rounds of analysis, two other researchers reviewed, confirmed, and verified the conclusions.FindingsSaudi Arabia's recent policy provisions for children with disabilities have included an emphasis on inclusion in general education schools. However, as with many countries, these policies have not yet been systematically implemented. Many students with more complex learning and behavioural needs continue to be excluded from general education classrooms.ConclusionRecommendations to support the implementation of inclusive educational services for students with intellectual disabilities in Saudi Arabia are provided.
Pathological changes within the cerebral vasculature in Alzheimer’s disease: New perspectives
Authors: Fisher Robert A. , Miners J. Scott , Love Seth 
Published: March 2022

AbstractCerebrovascular disease underpins vascular dementia (VaD), but structural and functional changes to the cerebral vasculature contribute to disease pathology and cognitive decline in Alzheimer's disease (AD). In this review, we discuss the contribution of cerebral amyloid angiopathy and non‐amyloid small vessel disease in AD, and the accompanying changes to the density, maintenance and remodelling of vessels (including alterations to the composition and function of the cerebrovascular basement membrane). We consider how abnormalities of the constituent cells of the neurovascular unit – particularly of endothelial cells and pericytes – and impairment of the blood‐brain barrier (BBB) impact on the pathogenesis of AD. We also discuss how changes to the cerebral vasculature are likely to impair Aβ clearance – both intra‐periarteriolar drainage (IPAD) and transport of Aβ peptides across the BBB, and how impaired neurovascular coupling and reduced blood flow in relation to metabolic demand increase amyloidogenic processing of APP and the production of Aβ. We review the vasoactive properties of Aβ peptides themselves, and the probable bi‐directional relationship between vascular dysfunction and Aβ accumulation in AD. Lastly, we discuss recent methodological advances in transcriptomics and imaging that have provided novel insights into vascular changes in AD, and recent advances in assessment of the retina that allow in vivo detection of vascular changes in the early stages of AD.
Contributions of bilingual home environment and language proficiency on children’s Spanish–English reading outcomes
Authors: Wagley Neelima , Marks Rebecca A. , Bedore Lisa M. , Kovelman Ioulia 
Published: March 2022

AbstractThis study examines the influence of language environment on language and reading skills and the cross‐linguistic contributions to reading outcomes in 132 Spanish–English bilingual children ages 7–12 (52% female; 98% Hispanic). We present three major findings: children's language knowledge is separable into general (e.g., phonological awareness) and language‐specific (e.g., meaning, grammar) skills; regular Spanish use positively relates to children's Spanish language and reading skills and does not limit English skills; and Spanish reading comprehension is positively associated with English reading comprehension. The model explains a significant percentage of the variance in English (R2 = .89) and Spanish (R2 = .87) reading comprehension outcomes. Findings shed light on the interdependence of Spanish and English as they relate to bilingual reading acquisition.
Six decades of environmental resource valuation in Canada: A synthesis of the literature
Authors: Macaskill James , Lloyd‐Smith Patrick 
Published: March 2022

AbstractThis paper synthesizes Canada's environmental valuation literature over the last six decades. Focusing on primary valuation benefit estimates, we link multiple research outputs from the same data collection effort to obtain an accurate measure of unique studies. We identify a total of 269 unique valuation studies conducted in Canada between 1964 and 2019. The number of valuation studies conducted per year has not increased since 1975 and the median data collection year is 1996. Stated preference (SP) methods are the most popular valuation approaches being used in more than 50% of studies and this share has increased to over 80% within the last decade. We discuss numerous gaps in our knowledge for certain environmental resources and regions, in particular Canada's three Northern territories. The paper provides information on the state of environmental valuation research in Canada and identifies future research needs.
Effect of the implant‐supported provisional restoration on the accuracy of digital peri‐implant mucosa replication–A clinical study
Authors: Xiong Jiabi , Sun Wei , Huang Bin , Ji Wei , Shi Bin 
Published: March 2022

AbstractObjectiveThis study aimed to quantitatively evaluate the effect of implant‐supported provisional restorations (ISPRs) on the accuracy of the intraoral scanned peri‐implant soft‐tissue profile in the esthetic area.Materials and MethodsSixteen patients with a single ISPR in the maxillary central incisor's region were recruited for this study. Three impression methods were sequentially used in each patient: (1) an intraoral scanning (IOS) with the ISPR, (2) a conventional impression using the ISPR as impression coping, and (3) a routine IOS without the ISPR. The stereolithography files of the three impression methods obtained from the same patient were superimposed, and the conventional impression method was used as the reference model. Two‐dimensional (2D) and three‐dimensional (3D) analyses were performed to measure the peri‐implant soft‐tissue deviation between the reference models and IOS from the groups with or without the ISPR, respectively. Data were presented as the means ± standard deviations. Two‐way analyses of variance with post hoc Sidak's multiple comparisons and paired t‐tests were performed for 2D and 3D analyses, respectively. The significance level was set at p < .05.ResultsThe peri‐implant mucosa without the ISPR immediately collapsed (<20 s), particularly on the palatine side of the labial mucosa and labial side of the palatine mucosa. Consequently, the IOS without the ISPR led to 414.7 ± 116.0 μm of overall dimensional deformation in the cuff‐like submucosal region, which was significantly larger (p < .0001) than that in the IOS with the ISPR (230.6 ± 85.5 μm).ConclusionImplant‐supported provisional restorations are important for accurate replication of the intraorally scanned peri‐implant soft‐tissue profile.
A broad focus on additional programmes prior to bariatric surgery: A systematic review
Authors: Lodewijks Yentl , van der Ven Roos , Nienhuijs Simon 
Published: March 2022

SummaryAdditional preoperative programmes may be beneficial for candidates who seek bariatric surgery, but there is no consensus on the optimal preparation. This systematic review aimed to summarize the effects of a preoperative programme on weight loss. A literature search was performed for Embase, Cinahl, PubMed and Cochrane Library. Studies on preoperative exercise, behaviour and/or diet programmes administered in adult patients in a bariatric trajectory measuring weight loss were included. Initial results yielded 2148 titles, 70 of which were thoroughly analysed and 37 articles were included, comprising 10 333 patients. Eleven out of 37 studies included postoperative weight loss as an outcome in interventions focused on diet (n = 5), behaviour (n = 2), exercise (n = 2) and a combination of interventions (n = 2). Only one study (9%) which administered exercise as a preoperative programme showed a significant effect on postoperative weight loss. In total, 33 studies included preoperative weight loss as an outcome, which was significant in 64% of the cases. It is difficult to draw conclusions from the investigated data as it was extremely heterogeneous concerning the intensity, duration and administration of a programme. Nevertheless, it seems that a preoperative weight loss programme seems beneficial in terms of preoperative weight loss, postoperative physical activity and improved mental health postinterventional. The use of a core outcome set is recommended for future studies.
Quantification of preservatives in tattoo and permanent make‐up inks in the frame of the new requirements under the REACH Regulation
Authors: Famele Marco , Lavalle Roberta , Leoni Claudia , Majorani Costanza , Ferranti Carolina , Palleschi Luca , Fava Luca , Draisci Rosa , D'Ilio Sonia 
Published: March 2022

AbstractBackgroundAccording to the REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) restriction, tattoo and permanent make‐up (PMU) inks placed on the European Union market after January 4, 2022, shall not contain methylisothiazolinone, benzisothiazolinone (BIT), octylisothiazolinone (OIT), or other skin sensitizers in concentrations of 10 mg/kg or higher and phenoxyethanol (PE) or other eye irritants or damaging substances in concentrations of 100 mg/kg or higher. In addition, preservatives and other substances enlisted in Annex II to Cosmetic Product Regulation shall not be present in concentrations of 0.5 mg/kg or higher.ObjectivesThis study aims to quantify 14 preservatives in 99 tattoo and 39 PMU inks from the Italian market and presents a comparison with concentration limits set by the REACH restriction.MethodsInks were analysed by applying validated analytical methods based on liquid chromatography techniques.ResultsAbout 24.0%, 15.2% and 1.5% of the overall samples contained BIT, PE and OIT, respectively, at concentrations exceeding REACH concentration limits. The number of noncompliant tattoo inks (49.5%) would be significantly greater than that of the PMU inks (17.9%).ConclusionsAbout 40.6% of the samples would be noncompliant with the restriction for the presence of preservatives above the permitted level. Additional concentration limits will apply to skin sensitizing preservatives for proper labelling of inks under CLP (Classification, Labelling and Packaging) Regulation.
Biomarkers and predictive models of early allograft dysfunction in liver transplantation – A systematic review of the literature, meta‐analysis, and expert panel recommendations
Authors: Liu Jiang , Martins Paulo N. , Bhat Mamatha , Pang Li , Yeung Oscar W.H. , Ng Kevin T.P. , Spiro Michael , Raptis Dimitri Aristotle , Man Kwan , Mas Valeria R. ,   the ERAS4OLT.org Working Group
Published: March 2022

AbstractBackgroundPrompt identification of early allograft dysfunction (EAD) is critical to reduce morbidity and mortality in liver transplant (LT) recipients.ObjectivesEvaluate the evidence supporting biomarkers that can provide diagnostic and predictive value for EAD.Data sourcesOvid MEDLINE, Embase, Scopus, Google Scholar, and Cochrane Central.MethodsSystematic review following PRISMA guidelines and recommendations using the GRADE approach was derived from an international expert panel. Studies that investigated biomarkers or models for predicting EAD in adult LT recipients were included for in‐depth evaluation and meta‐analysis. Olthoff's criteria were used as the standard reference for the diagnostic accuracy evaluation. PROSPERO ID: CRD42021293838ResultsTen studies were included for the systematic review. Lactate, lactate clearance, uric acid, Factor V, HMGB‐1, CRP to ALB ratio, phosphocholine, total cholesterol, and metabolomic predictive model were identified as potential early EAD predictive biomarkers. The sensitivity ranged between .39 and .92, while the specificity ranged from .63 to .90. Elevated lactate level was most indicative of EAD after adult LT (pooled diagnostic odds ratio of 7.15 (95%CI: 2.38‐21.46)). The quality of evidence (QOE) for lactate as indicator was moderate according to the GRADE approach, whereas the QOE for other biomarkers was very low to low likely as consequence of study design characteristics such as single study, small sample size, and large ranges of sensitivity or specificity.ConclusionsLactate is an early indicator to predict EAD after LT (Quality of Evidence: Moderate | Grade of Recommendation: Strong). Further multicenter studies and the use of machine perfusion setting should be implemented for validation.
Applications of scanning electron microscopy and focused ion beam milling in dental research
Authors: House Krystal L. , Pan Long , O'Carroll Deirdre M. , Xu Shiyou 
Published: March 2022

AbstractThe abilities of scanning electron microscopy (SEM) and focused ion beam (FIB) milling for obtaining high‐resolution images from top surfaces, cross‐sectional surfaces, and even in three dimensions, are becoming increasingly important for imaging and analyzing tooth structures such as enamel and dentin. FIB was originally developed for material research in the semiconductor industry. However, use of SEM/FIB has been growing recently in dental research due to the versatility of dual platform instruments that can be used as a milling device to obtain low‐artifact cross‐sections of samples combined with high‐resolution images. The advent of the SEM/FIB system and accessories may offer access to previously inaccessible length scales for characterizing tooth structures for dental research, opening exciting opportunities to address many central questions in dental research. New discoveries and fundamental breakthroughs in understanding are likely to follow. This review covers the applications, key findings, and future direction of SEM/FIB in dental research in morphology imaging, specimen preparation for transmission electron microscopy (TEM) analysis, and three‐dimensional volume imaging using SEM/FIB tomography.
Putting guidelines into practice: Using co‐design to develop a complex intervention based on NG48 to enable care staff to provide daily oral care to older people living in care homes
Authors: Langley Joe , Wassall Rebecca , Geddis‐Regan Andrew , Watson Sinead , Verey Anna , McKenna Gerald , Brocklehurst Paul , Tsakos Georgios 
Published: March 2022

AbstractObjectives(1) Explore the challenges of providing daily oral care in care homes; (2) understand oral care practices provided by care home staff; (3) co‐design practical resources supporting care home staff in these activities.MethodsThree Sheffield care homes were identified via the “ENRICH Research Ready Care Home Network,” and three to six staff per site were recruited as co‐design partners. Design researchers led three co‐design workshops exploring care home staff's experiences of providing daily oral care, including challenges, coping strategies and the role of current guidelines. New resources were prototyped to support the use of guidelines in practice. The design researchers developed final resources to enable the use of these guidelines in‐practice‐in‐context.FindingsCare home staff operate under time and resource constraints. The proportion of residents with dementia and other neurodegenerative conditions is rapidly increasing. Care home staff face challenges when residents adopt “refusal behaviours” and balancing daily oral care needs with resident and carer safety becomes complex. Care home staff have developed many coping strategies to navigate “refusal behaviours.” Supporting resources need to “fit” within the complexities of practice‐in‐context.ConclusionsThe provision of daily oral care practices in care homes is complex and challenging. The co‐design process revealed care home staff have a “library” of context‐specific practical knowledge and coping strategies. This study offers insights into the process of making guidelines usable for professionals in their contexts of practice, exploring the agenda of implementing evidence‐based guidelines.
Highly skilled (re‐)migrants in multinational enterprises: Facilitators of cross‐border knowledge transfers
Authors: Verfürth Philip 
Published: March 2022

AbstractThe aim of this article is to examine how externally recruited, highly skilled (re‐)migrants facilitate cross‐border knowledge transfers in multinational enterprises (MNEs). To achieve this goal, an actor‐centred research perspective will be adopted, which allows for a detailed examination of both individual employees involved in MNEs cross‐border knowledge transfers as well as organizational strategies to facilitate and structure knowledge transfers. Empirically, the article is based on the example of highly skilled (re‐)migrants of Turkish origin, who obtained a university degree in Germany, then (re‐)migrated to Turkey and work in subsidiaries of German MNEs. The empirical results show that highly skilled (re‐)migrants of Turkish origin are strategically used to work at interface positions between German and Turkish business units. Based on their professional expertise, dual societal embeddedness and profound language skills, highly skilled (re‐)migrants facilitate cross‐border knowledge transfers by building social proximity and bridging institutional distances. Overall, the article contributes to the micro‐foundation of cross‐border knowledge transfers in MNEs.
Effects of Chinese herbal medicine in patients with benign prostatic hyperplasia: A nationwide cohort study in Taiwan
Authors: Ou Shi‐Chen , Huang Sheng‐Teng , Lin Mei‐Chen , Chen Wen‐Chi , Huang Chi‐Ping , Lin Hung‐Jen 
Published: March 2022

ObjectivesBenign prostatic hyperplasia affects elderly males, with progression presenting the risk of urinary complications and eventual surgical intervention. We aimed to evaluate the effects of Chinese herbal medicine in patients with benign prostatic hyperplasia.MethodsThis retrospective cohort study analyzed claims data in Taiwan’s National Health Insurance Research Database from 2001 to 2013. A total of 4142 patients newly diagnosed as benign prostatic hyperplasia were enrolled and divided into cohorts of Chinese herbal medicine users and nonusers by performing 1:1 propensity score matching. The risk of benign prostatic hyperplasia‐related complications was assessed by the Cox proportional hazard model. The cumulative incidence of benign prostatic hyperplasia‐related surgeries was assessed by Kaplan–Meier method.ResultsDuring the study period, the risk of benign prostatic hyperplasia‐related complications was lower in the Chinese herbal medicine cohort than non‐Chinese herbal medicine cohort with an adjusted hazard ratio of 0.82 (95% confidence interval 0.73–0.92) after controlling for multiple variables. Subgroup analysis revealed that Chinese herbal medicine users had a significantly lower risk of urinary tract infection (adjusted hazard ratio 0.67, 95% confidence interval 0.50–0.89) and urinary retention (adjusted hazard ratio 0.83, 95% confidence interval 0.72–0.97). In addition, Chinese herbal medicine users also had a lower incidence rate of benign prostatic hyperplasia‐related surgery (32.14 vs 40.20, adjusted hazard ratio 0.74, 95% confidence interval 0.61–0.89) and a longer surgery‐free interval than non‐Chinese herbal medicine users (3.98 vs 3.00 mean person‐year, P < 0.001). Data revealed Salviae miltiorrhizae and Ji‐Sheng‐Shen‐Qi‐Wan as the most commonly prescribed Chinese herbal medicine by traditional Chinese medicine practitioners.ConclusionsOur study demonstrated that Chinese herbal medicine might have effects in the benign prostatic hyperplasia‐related complications and surgeries in patients with benign prostatic hyperplasia.
Serum microRNA as liquid biopsy biomarker for the prediction of oncological outcomes in patients with bladder cancer
Authors: Urabe Fumihiko , Matsuzaki Juntaro , Ito Kagenori , Takamori Hajime , Tsuzuki Shunsuke , Miki Jun , Kimura Takahiro , Egawa Shin , Nakamura Eijiro , Matsui Yoshiyuki , Fujimoto Hiroyuki , Yamamoto Yusuke , Ochiya Takahiro 
Published: March 2022

ObjectivesRadical cystectomy is the gold‐standard treatment for muscle‐invasive bladder cancer and aggressive non‐muscle‐invasive bladder cancer. To enhance clinical decision‐making regarding patients with bladder cancer who underwent radical cystectomy, a recurrence prediction biomarker with high accuracy is urgently needed. In this study, we developed a model for the prediction of bladder cancer recurrence after radical cystectomy by combining serum microRNA and a pathological factor.MethodsWe retrospectively analyzed the clinical records of 81 patients with bladder cancer who underwent radical cystectomy between 2008 and 2016. The dataset was divided into two, and Fisher linear discriminant analysis was used to construct a prognostic model for future recurrence in the training set (n = 41). The performance of the model was evaluated in the validation set (n = 40).ResultsThirty patients had recurrence after having undergone radical cystectomy. A prognostic model for recurrence was constructed by combining a pathological factor (i.e. positive pathological lymph node status) and three microRNAs (miR‐23a‐3p, miR‐3679‐3p, and miR‐3195). The model showed a sensitivity of 0.87, a specificity of 0.80, and an area under the receiver operating characteristic curve of 0.88 (0.77–0.98) in the validation set. Furthermore, Kaplan–Meier analysis revealed that patients with a low prediction index have significantly longer overall survival than patients with a high prediction index (P = 0.041).ConclusionA combination of serum microRNA profiles and lymph node statuses is useful for the prediction of oncological outcomes after radical cystectomy in patients with bladder cancer.
Social responsibility, moral hazard, and collateral requirement: Evidence from a quasi‐natural experiment in India
Authors: Jadiyappa Nemiraja , Shrivastava Santosh , Ghalke Avinash 
Published: March 2022

AbstractThe stakeholder theory predicts that corporate social responsibility (CSR) activities reduce the morale hazard problem between creditors and corporate firms and decrease the requirement of collaterals in debt transactions. Consistent with this theory, our analysis shows that there is a negative relationship between CSR and secured debt in a cross‐section of firms. Further, by using the mandatory CSR regulation implemented in India as a quasi‐natural experiment setting, we observe the same negative relationship across periods in firms that were impacted by the regulation. These results suggest that CSR activities may substitute collaterals for obtaining debt from financial institutions, especially banks.