bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disparities in Guideline-Concordant Treatment and Survival Among Border County Residents With Gastric Cancer
Authors: Ju Michelle R. , Wang Sam C. , Mansour John C. , Polanco Patricio M. , Yopp Adam C. , Zeh Herbert J. , Porembka Matthew R. 
Published: February 2022

PURPOSE: Previous studies have shown health disparities among US-Mexico border county (BC) residents. However, the impact of BC residence on gastric cancer treatment and survival outcomes is unknown. Our study compares the receipt of guideline-concordant care (GCC) and survival for patients with gastric cancer by BC status. METHODS: We conducted a retrospective review of adult non-Hispanic White and Hispanic patients with gastric adenocarcinoma diagnosed between 2004 and 2017 in the Texas Cancer Registry. Chi-square tests were used to compare categorical group differences, with pooled t-tests used to compare group means. The impact of BC residence on likelihood of receiving GCC was assessed with logistic regression. Overall survival was estimated using the Kaplan-Meier method and compared with log-rank tests. RESULTS: Our cohort consisted of 12,514 patients (15% BC). Overall, 45% of nonborder county residents received GCC versus 35% of BC residents ( P < .0001). After adjusting for age, race, stage, and insurance status, BC patients remained significantly less likely to receive GCC (odds ratio 0.69; 95% CI, 0.61 to 0.78). BC residence was associated with increased hazard of all-cause mortality after accounting for age, race, stage, poverty index, and treatment receipt (hazard ratio 1.11; 95% CI, 1.04 to 1.18). BC residents had significantly worse overall survival for localized and regional disease. CONCLUSION: BC residents with gastric cancer are less likely to receive GCC and have significantly worse survival outcomes than nonborder county residents. This highlights significant health care disparities arising from the lack of health care access and multiple social determinants of health. Further studies are needed to identify specific contributing mechanisms to improve health care equity.
Universal patterns in multifrequency-driven dissipative systems
Authors: Olivera-Atencio M. L. , Lamata L. , Kohler S. , Casado-Pascual J. 
Published: February 2022

Abstract
The response of dissipative systems to multi-chromatic fields exhibits generic properties which follow from the discrete time-translation symmetry of each driving component. We derive these properties and illustrate them with paradigmatic examples of classical and quantum dissipative systems. In addition, some computational aspects, in particular a matrix continued-fraction method, are discussed. Moreover, we propose possible implementations with quantum optical settings.
Detecting wetland encroachment and urban agriculture land classification in Uganda using hyper-temporal remote sensing
Authors: Kabiri Stella , Allen Molly , Okuonzia Juduth Toma , Akello Beatrice , Ssabaganzi Rebecca , Mubiru Drake 
Published: February 2022

Background: Urbanization is an important indicator of economic growth and social change but is associated with environmental degradation, which threatens the sustainable growth of African cities. One of the most vulnerable ecosystems in urban areas are wetlands. In Uganda, wetlands cover an area of 11% of the country’s land area. Half of the wetland areas in Ugandan cities have been converted to industrial and residential areas, and urban agriculture. There is limited information on the extent of wetland conversion or utilization for urban agriculture. The objective of this study was to investigate the extent of wetlands lost in two Ugandan cities, Wakiso and Kampala, in the last 30 years. Secondly, we extracted crop agriculture in the wetlands of Kampala and Wakiso from hyper-temporal satellite image analysis in an attempt to produce a spatial detail of wetland encroachment maps of urban agriculture using a reproducible mapmaking method. Methods: Using a field survey and free remote sensing data from Landsat TM 1986 and Landsat ETM 2016 we classified the rate of wetland loss and encroachment between the years 1986 and 2016. We used MODIS NDVI 16-day composites at a 500-meter spatial resolution to broaden the analysis to distinguish distinctive crops and crop mixtures in the encroached wetlands for urban agriculture using the ISODATA clustering algorithm. Results: Over 30 years, 72,828 ha (73%) of the Wakiso-Kampala wetlands have been lost meanwhile agriculture areas have doubled. Of this 16,488 ha (23%) were converted from wetlands. All cultivated agriculture in Kampala was in the wetlands while in Wakiso, 73% of crop agriculture was in the wetlands. The major crops grown in these urban wetlands were banana (20%), sugarcane (22%), maize (17%), Eucalyptus trees (12%), sweet potatoes (10%), while ornamental nurseries, pine trees, vegetables, and passion fruits were each at 5%.
Case Report: Bocavirus Infection Radiologically Resembling a Congestive Heart Failure in a Patient with Metastatic Castration-Resistant Prostate Cancer Case-Report
Authors: Benitez Fuentes Javier David , de Luna Aguilar Alicia , Flores Navarro Paloma , Lopez de Sa Lorenzo Alfonso , Toledano Rojas Carmen , Laguna Fonseca Berta , Shah Richa , Frick Clara , Jimenez Ortega Alejandro Francisco , Vidal Cassinello Natalia 
Published: February 2022

Background: Human bocavirus (HBoV) is a viral pathogen from the genus Bocaparvovirus (family Parvoviridae, subfamily Parvovirinae) discovered in 2005. Most of available literature is about HBoV in children and adults with hematological malignancies and in otherwise healthy children with respiratory infections. Information regarding infection in the adult population with solid tumors is scarce. Case Report: We report the case of a 51-year-old male with metastatic castration resistant prostate cancer undergoing chemotherapy treatment who presented with fever, dyspnea, dry cough, and pleuritic pain. Imaging techniques showed signs of congestive heart failure. Symptoms, laboratory tests and echocardiography revealed a more probable infectious etiology. Antibiotic therapy was started. A polymerase chain reaction (PCR) test of nasopharyngeal exudate for respiratory viruses was positive for HBoV. The rest of the microbiological tests were negative. Bronchoalveolar lavage (BAL) was performed. Bacterial culture of BAL was negative while respiratory virus PCR confirmed positivity for HBoV. Antibiotic therapy was discontinued. The patient gradually recovered. Conclusions: Emerging infectious diseases are a notorious threat for immunocompromised populations such as solid tumor patients. This case is unique because to our knowledge this is the first case report article of HBoV in a solid tumor patient and because imaging techniques exhibited signs of congestive heart failure that did not correlate with the rest of the tests. It shows that unusual pathogens should be considered when managing serious clinical complications with uncommon presentations in cancer patients. Notable diagnostic efforts should be made to reach a diagnosis in these cases.
Case Report: Fortuitous discovery of cor triatriatum sinister in a young adult
Authors: Asma Achour , Ben Slima Mohamed Kacem , Ikram Chamtouri , Ammar Aida , Abdelali Mabrouk , Saad Jamel , Hmida Badii , Zrig Ahmed , Ben Massoud Mejdi , Mnari Walid , Maatouk Mezri 
Published: February 2022

Cor triatriatum is an extremely rare cardiac congenital malformation characterized by subdivision of the left atrium into two chambers. This division is due to the presence of an abnormal fibromuscular membrane interrupted by one or more openings that communicate the two chambers. The size and number of those orifices is variable, affecting the age of onset of symptoms and their severity. Our case describes the fortuitous discovery of this pathology in a young adult in her forties, following the finding of atrial fibrillation during a preoperative assessment of a strangulated hernia. The cardiac ultrasound allowed in our case to invoke the diagnosis, confirmed thereafter with an angioscanner. Surgical resection was not required in our patient who was put on medical treatment involving a beta-blocker to reduce atrial fibrillation and an anticoagulant treatment to decrease the thromboembolic risk, with a good clinical evolution. It seems therefore interesting to consider this uncommon pathology which may be latent for a long time, manifesting after some physiological or pathological situations.
Current management of adults receiving oral anti-cancer medications: A scoping review protocol
Authors: Richmond Janice P. , Kelly Mary Grace , Johnston Alison , Hynes Lisa , Murphy Patrick J. , Murphy Andrew W. 
Published: February 2022

Oncology has been undergoing a profound transition in the last ten years with the increased usage in oral anti-cancer medication. Approximately 25% of all anti-cancer medication is now designed for oral use and this is likely to increase prospectively. These treatments are convenient for patients and are often preferred by them, yet there are similar safety and toxicity concerns as there are to intravenous treatment. Oral anti-cancer medications (OAMs) have the potential to alleviate capacity issues in cancer treating units as patients receive their treatment at home, however there remains a requirement for safe and efficient assessment and care. Consequently, the management of patients on OAMs is of paramount importance. The optimum setting, whether within primary or secondary care, in addition to the appropriate health care professional to carry out patient assessment and monitoring needs to be established. This paper presents a protocol for a scoping review which aims to systematically and comprehensively map the literature on the current management of adults receiving OAMs. The review will follow the published guidance to direct the various steps involved. The protocol will be guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) framework to ensure methodological and reporting quality. Independent full text review will be performed by two reviewers and any disagreements resolved through discussion with a third reviewer. The process will be iterative in nature. This scoping review will provide a narrative synthesis and map the literature on the management of individuals receiving OAMs. This work is an appropriate initial stage in presenting the literature to inform the subsequent steps in a multi-phased research study which aims to establish and analyse the safety and efficacy of an integrated care model for the management of patients receiving OAM in the community by an advanced practitioner.
The Battle for Homes: How Does Home Sharing Disrupt Local Residential Markets?
Authors: Chen Wei , Wei Zaiyan , Xie Karen 
Published: February 2022

As cities debate how to regulate Airbnb and other home-sharing services, we study the impacts of home sharing on local residential real estate markets. By accommodating transient travelers with short-term rental properties, home-sharing platforms have evolved as a major alternative channel that attracts the growing supply of residential properties. However, on the demand side of local residential markets, home-sharing platforms are not a viable option for residents. To demonstrate this dynamic between home sharing and local residential markets, we leverage a unique quasi-experiment on Airbnb—a platform policy that caps the number of properties a host can manage in a city—and find that the policy reduced rents (in the long-term rental markets) and home values (in the for-sale housing markets) by about 3% and did not affect the price-to-rent ratio. Consistent with the conjecture, we find that the policy impacts can be attributed to increased supply in local residential markets because of the policy. Quantitatively, our estimates suggest that, if the density of affected Airbnb properties is 1% higher in a market, the policy may further decrease rents and home values by about 0.03%–0.06%, which is similar across each policy-affected city. Our empirical findings add to the debate about the impacts of home sharing on local residential markets with a novel data set and a unique identification strategy. Practically speaking, our research is a timely response to the debate on regulating home sharing and has implications for various stakeholders of the residential real estate markets. This paper was accepted by Chris Forman, information systems. Funding: K. Xie thanks the University of Denver Faculty Research Fund 2017 for financial support. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2022.4299 .
Modeling the Risk in Mortality Projections
Authors: Zhu Nan , Bauer Daniel 
Published: February 2022

Capturing the Uncertainty in Long-Term Mortality Forecasts The uncertainty in future longevity presents a substantial risk factor for insurance companies, pension funds, and retirement systems. In “Modeling the Risk in Mortality Projections,” Zhu and Bauer present novel stochastic models for analyzing this longevity risk that focus on the uncertainty associated with long-term mortality projections and capture the evolution of mortality forecasts over the past decades. They arrive at their models by analyzing time series of mortality forecasts in a forward modeling framework, which contrasts with conventional stochastic mortality models that are built on age-specific realized mortality rates. The authors showcase their models in exemplifying financial applications in both traditional life insurance markets and the emerging longevity risk transfer market. A key takeaway is that uncertainty in positions that depend on the long-term evolution of mortality is substantially greater under their models than suggested by conventional models.
The root of the cause: a clinical case report of the surgical removal of a retained root via an extra-oral approach
Authors: Loh Melissa , Azam Hamnah , Jones David Carl 
Published: February 2022

Retained roots are commonly seen as an incidental finding in general practice following radiographic examination, many being asymptomatic. However, over time they may migrate, develop pathological change and become symptomatic for the patient. This article illustrates root migration using an interesting clinical case to demonstrate how it can present, and the surgical techniques required in its removal. In this particular case, the retained root of a lower right second molar migrated to below the right side of the inferior alveolar nerve. CPD/Clinical Relevance: It is important to recognize when referral for a specialist opinion is appropriate.
Comparison of the effects of empagliflozin and glimepiride on endothelial function in patients with type 2 diabetes: A randomized controlled study
Authors: Tamura Haruka , Kondo Yoshinobu , Ito Kohei , Hasebe Masanori , Satoh Shinobu , Terauchi Yasuo 
Published: February 2022

Patients with type 2 diabetes who have cardiovascular disease and are receiving empagliflozin have a lower rate of primary composite cardiovascular outcomes. In contrast, glimepiride increases cardiovascular hospitalization when combined with metformin. Here, we assessed the effects of empagliflozin and glimepiride on endothelial function using flow-mediated dilation (FMD). In this prospective, open-label, randomized, parallel-group study, 63 patients with type 2 diabetes received metformin and insulin glargine U100 for 12 weeks. This was followed by additional treatment with empagliflozin or glimepiride for 12 weeks. The primary outcome was the change in the FMD measurement (ΔFMDs) at 24 weeks of additional treatment. Secondary outcomes comprised changes in metabolic markers and body composition. The empagliflozin group (n = 33) and glimepiride group (n = 30) showed no significant differences in ΔFMDs (empagliflozin, −0.11 [95%CI: -1.02, 0.80]%; glimepiride, −0.34 [95%CI: -1.28, 0.60]%; P = 0.73). Additionally, changes in glycated hemoglobin were similar between the two groups. However, a significant difference in body weight change was observed (empagliflozin, −0.58 [95%CI: -1.60, 0.43] kg; glimepiride, 1.20 [95%CI: 0.15, 2.26] kg; P = 0.02). Moreover, a body composition analysis revealed that body fluid volume significantly decreased after empagliflozin treatment (baseline, 35.8 ± 6.8 L; after 12 weeks, −0.33 ± 0.72 L; P = 0.03). Hence, although empagliflozin did not improve endothelial function compared with glimepiride for patients with type 2 diabetes, it did decrease body fluid volumes. Thus, the coronary-protective effect of empagliflozin is not derived from endothelial function protection, but rather from heart failure risk reduction.
Trial registration: This trial was registered on September 13, 2016; UMIN000024001.
Variation in regional implantation patterns of cardiac implantable electronic device in Switzerland
Authors: Bolt Lucy , Wertli Maria M. , Haynes Alan G. , Rodondi Nicolas , Chiolero Arnaud , Panczak Radoslaw , Aujesky Drahomir 
Published: February 2022

Introduction
There is a substantial geographical variation in the rates of pacemaker (PM), implantable cardioverter defibrillator (ICD), and cardiac resynchronization therapy (CRT) device implantation across European countries. We assessed the extent of regional variation and potential determinants of such variation.

Methods
We conducted a population-based analysis using discharge data for PM/ICD/CRT implantations from all Swiss acute care hospitals during 2013–2016. We derived hospital service areas (HSA) by analyzing patient flows. We calculated age- and sex-standardized rates and quantified variation using the extremal quotient (EQ) and the systemic component of variation (SCV). We estimated the reduction in variance of crude implantation rates across HSAs using multilevel regression models, with incremental adjustment for age and sex, language, socioeconomic factors, population health, diabetes mellitus, and the density of cardiologists on the HSA level.

Results
We analyzed implantations of 8129 PM, 1461 ICD, and 1411 CRT from 25 Swiss HSAs. The mean age- and sex-standardized implantation rate was 29 (range 8–57) per 100,000 persons for PM, 5 (1–9) for ICD, and 5 (2–8) for CRT. There was a very high variation in PM (EQ 7.0; SCV 12.6) and ICD (EQ 7.2; SCV 11.3) and a high variation in CRT implantation rates (EQ 3.9; SCV 7.1) across HSAs. Adjustments for age and sex, language, socioeconomic factors, population health, diabetes mellitus, and density of cardiologists explained 94% of the variance in ICD and 87.5% of the variance in CRT implantation rates, but only 36.3% of the variance in PM implantation rates. Women had substantially lower PM/ICD/CRT implantation rates than men.

Conclusion
Switzerland has a very high regional variation in PM/ICD implantation and a high variation in CRT implantation rates. Women had substantially lower implantation rates than men. A large share of the variation in PM procedure rates remained unexplained which might reflect variations in physicians’ preferences and practices.
Variations of the quality of care during the COVID-19 pandemic affected the mortality rate of non-COVID-19 patients with hip fracture
Authors: Golinelli Davide , Sanmarchi Francesco , Capodici Angelo , Gribaudo Giorgia , Altini Mattia , Rosa Simona , Esposito Francesco , Fantini Maria Pia , Lenzi Jacopo 
Published: February 2022

Introduction
As COVID-19 roared through the world, governments worldwide enforced containment measures that affected various treatment pathways, including those for hip fractures (HFs). This study aimed to measure process and outcome indicators related to the quality of care provided to non-COVID-19 elderly patients affected by HF in Emilia-Romagna, a region of Italy severely hit by the pandemic.

Methods
We collected the hospital discharge records of all patients admitted to the hospitals of Emilia-Romagna with a diagnosis of HF from January to May in the years 2019 (pre-pandemic period) and 2020 (pandemic period). We analyzed surgery rate, surgery delays, length of hospital stay, timely rehabilitation, and 30-day mortality for each HF patient. We evaluated monthly data (2020 vs. 2019) with the chi-square and t-test, where appropriate. Logistic regression was used to investigate the differences in 30-day mortality.

Results
Our study included 5379 patients with HF. In April and May 2020, there was a significant increase in the proportion of HF patients that did not undergo timely surgery. In March 2020, we found a significant increase in mortality (OR = 2.22). Male sex (OR = 1.92), age ≥90 years (OR = 4.33), surgery after 48 hours (OR = 3.08) and not receiving surgery (OR = 6.19) were significantly associated with increased mortality. After adjusting for the aforementioned factors, patients hospitalized in March 2020 still suffered higher mortality (OR = 2.21).

Conclusions
There was a reduction in the overall quality of care provided to non-COVID-19 elderly patients affected by HF, whose mortality increased in March 2020. Patients’ characteristics and variations in processes of care partially explained this increase. Policymakers and professionals involved in the management of COVID-19 patients should be aware of the needs of patients with other health needs, which should be carefully investigated and included in future emergency preparedness and response plans.
Effect of Broiler Litter Based Complete Feed Fermentation Time on Nutrient Content and In vitro Digestibility
Authors: Kilimpares Nikomedes Anndhana Engtian , Firzatullah Raka Zacky , Andara Dhita Indah , Mukodiningsih Sri 
Published: February 2022

Broiler litter waste is increasing as the population of broiler chickens increases, on the other hand the need for ruminant feed is increasing so that alternative feeds are needed in the form of complete feed made from litter. This study was aimed to determine the effect of fermentation time on the nutritional content and digestibility of the complete feed. A completely randomized design with 4 treatments and 5 replications were applied in this study. Treatment T0 = not fermented; T1 = fermentation for 10 days; T2 = fermentation for 24 days; T3 = fermentation for 38 days. Parameters observed were nutrient content, VFA, NH3, dry matter digestibility and organic matter digestibility <em>in vitro</em> using cow rumen. Results showed that fermention of complete feed with 2.5% EM4 starter and 5% probiofeed for 38 days (T3) had a significant effect (P&lt;0.05) on nutrient content, dry matter digestibility, organic matter digestibility, VFA and NH3. The T3 significantly affected ash content, crude fat, crude protein, BETN, TDN, dry matter digestibility, organic matter digestibility, VFA, and NH3 but had no significant effect on water content and crude fiber. It is concluded that the complete feed could be used as an alternative feed for ruminants, and it is easy to obtain, cheap and able to reduce environmental pollution.