bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chloroform Extract of Plumbago zeylanica Linn. Roots Ameliorates the Epidermal Thickness of Imiquimod-induced Psoriatic Mice through Cell Cycle and Apoptosis
Authors: Purwoko Mitayani , Indarto Dono , Kariosentono Harijono , Purwanto Bambang , Soetrisno Soetrisno , Cilmiaty Risya 
Published: June 2022

Introduction: Psoriasis vulgaris is a chronic skin disease which is characterized by recurrent scales on skin. The global prevalence of this disease has increased in ten years. Plumbagin is an active compound in the P. zeylanica Linn. Some recent studies revealed that P. zeylanica Linn extracts have the antiproliferative activity, which is used for treatment of some human diseases. The aim of this study was to investigated the effect of Chloroform extract of P. zeylanica Linn roots (CEP) on epidermal thickness of Imiquimod-induced psoriatic mice.

Methods: This was a post-test only control group design. A total of 42 male BALB/c mice was divided into six groups. Mice in treatment groups orally received 25, 50, and 100 mg/kg body weight CEP, respectively while positive control orally received 1 mg/kg body weight Methotrexate for seven days. Evaluation of epidermal thickness based on histological changes, serum IL-23 level by ELISA, and Cyclin-dependent kinase 2, Cyclin A, and Caspase-3 expressions by immunohistochemistry.

Results: Administrations of CEP decreased the epidermal thickness of psoriatic plaques in all treatment groups (p = 0.002, 0.003, and 0.016 respectively) compared to negative control but it did not reduce the serum IL-23 level. The expressions of CDK2 and Cyclin A reduced in T2 and T3 groups and the expression of Caspase-3 increased was only in T3 group.

Conclusion: Chloroform extract of P. zeylanica Linn roots administrations reduce the epidermal thickness of Imiquimod-induced psoriatic mice by inhibition of keratinocyte cell cycle and induction of Caspase-3 expression.
L’Algérie à la recherche d’une diplomatie égarée
Authors: Abderrahim Kader A. 
Published: June 2022

Hier phare du tiers-monde, la diplomatie algérienne connaît une éclipse depuis la fin des années 1980. En dépit des efforts des débuts de la présidence Bouteflika, Alger s'est marginalisée face aux désordres de la région : Sahara occidental, printemps arabes, instabilité tunisienne, anarchie libyenne, déstabilisation du Sahel. L'Algérie amorce un réengagement régional mais, au-delà, le rapprochement vis-à-vis des États-Unis et de l'Union européenne reste ambigu, et la carte chinoise ambivalente.
La fécondité des filles de moins de 15 ans dans le monde
Authors: Schoumaker Bruno , Sánchez-Páez David A. 
Published: June 2022

On compterait autour de 400 000 naissances de mères de moins de 15 ans chaque année dans le monde dans les années 2010, soit un taux de fécondité de 13 naissances par an pour 10 000 filles de 10-14 ans. Plus de la moitié surviennent en Afrique subsaharienne où on observe 40 naissances annuelles pour 10 000 filles de 10-14 ans. Le taux de fécondité entre 10 et 14 ans a été divisé par environ six dans le monde depuis le début des années 1970. Dans les pays du Sud, une majorité de ces naissances ont lieu au sein d’unions (mariage ou cohabitation sans mariage).
Chemical-functional composition of Terminalia catappa oils from different varieties
Authors: Santos O.V. , Soares S.D. , Dias P.C.S. , Duarte S.P.A. , Santos M.P.L. , Nascimento F.C.A. , Teixeira-Costa B.E. 
Published: June 2022

This study aimed to extract and physical-chemically characterize Terminalia catappa L. kernel oil from purple (CR) and yellow (CA) varieties. Physical-chemical parameters, composition of fatty acids, nutritional quality indices, bioactive compounds and antioxidant capacity of both oil varieties were evaluated according to the literature. Both oils presented low levels of acidity and peroxides, besides the predominance of unsaturated fatty acids, ~63% of oleic and ~26% of linoleic acids, which influenced its nutritional indices. The CR oil variety exhibited a higher content in anthocyanin (18.3 ± 1.5 mg·100 g-1), ascorbic acid (68.4 ± 2.02 mg·100 g-1) and total polyphenol contents (152.3 ± 2.4 mg GAE·g-1), and a good antioxidant activity (38.6 ± 2.2 μg TE·g-1) determined by TEAC assay, when compared to the CA oil (p < 0.05). Therefore, the results confirm the importance of T. catappa as a lipid source for human consumption to be used in the development of food products.
Supports et pratiques de l’écriture poétique dans les centres de détention légaux et clandestins de la dernière dictature argentine
Authors: Guillard Amandine 
Published: June 2022

Ce travail propose d’analyser l’origine d’une partie des manuscrits des poèmes composés par les prisonniers politiques pendant la dernière dictature argentine, entre 1976 et 1983. Il s’agit plus particulièrement de nous intéresser aux lieux, aux supports et aux pratiques de l’écriture poétique qui s’est développée de façon surprenante et inespérée malgré les conditions éminemment précaires auxquelles étaient exposés les auteurs. Nous n’allons pas réaliser l’analyse littéraire des poèmes mais plutôt démontrer, d’une part, que les lieux de détention ont été, en même temps et paradoxalement, des lieux de création. D’autre part, il s’agira de voir que, malgré les obstacles pensés et tendus par les autorités pénitentiaires, divers supports et pratiques ont surgi pour permettre la diffusion et circulation de cette poésie « inattendue ».
Anxiety and depression in patients with post-surgical dysphagia in Sri Lanka
Authors: Fernando G. K. S. , Fernando W. K. T. R. , De Silva M. D. K. 
Published: June 2022

Background: Undiagnosed anxiety and depression are obstacles for the effective treatment of post-surgical dysphagia. The prevalence and associations between postsurgical dysphagia and anxiety and depression are poorly studied areas in Sri Lanka.
Aims: This study aimed to determine the proportion of anxiety and depression among patients with dysphagia following oral, oral maxillofacial (OMF), and neck surgeries, and to identify the associations between the severity and stage of dysphagia, and the occurrence of anxiety and depression.
Methods: A cross-sectional study was conducted among 95 participants with post-operative dysphagia following oral, OMF and neck surgeries, at four tertiary care hospitals. The Hospital Anxiety and Depression Scale, oral-motor and cranial nerve examination, the 3ml water swallow test, cervical auscultation and the Dysphagia Severity Rating Scale were used for data collection.
Results: The majority of the participants (52%) presented with dysphagia in the pharyngeal phase, and 51% presented with severe dysphagia. Among the participants, 52% screened positive for depression and 39% for anxiety, while 37% and 47% showed borderline levels of depression and anxiety respectively. There was a statistically significant association between increasing severity of dysphagia and increasing levels of anxiety.
Conclusions: This study reflects that there is a high psychological burden among patients with dysphagia following oral, OMF, and neck surgeries. This highlights the need for the incorporation of interdisciplinary treatment strategies, as undiagnosed anxiety and depression are likely to impact negatively on the rehabilitation and management of patients with dysphagia.
Eenheid en gelykheid uitgedruk deur die metafoor van die wapenrusting in Efesiers 6:10-18
Authors: Vrey Alta 
Published: June 2022

The Holy Spirit and the Word of God are gifts to the whole church. Every believer in Jesus Christ is part of the body of Christ, the temple of God, the household of the Father and the army of the Spirit. One of the main themes of the letter to the Ephesians is unification in Christ between Jews and Gentiles. The author concludes his letter in Ephesians 6:10 with the metaphor of the armour of God: ‘In conclusion, be strong in the Lord [be empowered through your union with Him] and in the power of His might.’ (AMP). Our union with Christ, which should be reflected in our union with other believers, empower us to be strong in our fight against evil in this world. Unification cannot be complete if the value of each member is not acknowledged. Though roles may differ, the value of each member is measured by the price that Christ paid on the cross for our redemption. Equality unite; inequality divide. Equality for all members of Christ’s church is essential in the fight against evil powers like domination and inequality.The writer of Ephesians uses metaphors to convey the message of unification and equality, especially between Jews and Gentiles, in the newly formed first century church. Unfortunately the position of slaves, woman and children in the church are still subject to cultural norms and values of the time.The message of this letter should be filtered through the lens of patriarchy in the first century Mediterranean world. According to Osiek the whole Mediterranean society was patriarchal (2006:832). The metaphor of the Roman soldier’s armour is a male image used to describe a spiritual war in which all believers are involved. The equality in today’s society should not be limited by cultural first century boundaries, in Ephesians the fight against evil should be an example of the unification and equality of gender, ethnicity, social status and age groups.ContributionThe metaphor of the armour of God describe the spiritual fight against evil powers and although the image of a male Roman soldier is used, the fight is not limited to male members of the church. Every believer is valuable enough that Christ died for him/her and therefore every believer should be equal in the army of God. The empowering strength of the Holy Spirit should bring equality and unity in the church.
Developing and prioritising strategies to improve the implementation of maternal healthcare guidelines in South Africa: The nominal group technique
Authors: Ramavhoya Thifhelimbilu I. , Maputle Maria S. , Lebese Tinyiko R. 
Published: June 2022

Background: In South Africa, maternal healthcare guidelines are distributed to primary health care (PHC) facility for midwives to refer and implement during maternal healthcare services. Different training was offered for the use of maternal care guidelines. However, poor adherence and poor implementation of guidelines were discovered.Aim: This study aimed to develop and prioritise strategies to improve the implementation of maternal healthcare guidelines at PHC facilities of Limpopo province, South Africa.Method: Strengths, weaknesses, opportunities and threats analysis and its matrix together with the nominal group technique were used to develop the current strategy. Midwives, maternal, assistant and operational managers from PHC facilities of the two selected district of the Limpopo province were selected. Criterion-based purposive sampling was used to select participants. Data collection and analysis involved the four steps used in the nominal group technique.Results: Strategies related to strengths and weaknesses such as human resources, maternal health services and knowledge deficit were identified. Opportunities and threats such as availability of guidelines, community involvement and quality assurance as factors that influenced the provision of maternal healthcare services were identified.Conclusion: Researchers formulated actions that could build on identified strengths, overcome weaknesses such as human resources, explore opportunities and mitigate the threats such as quality assurance. Implementation of the developed strategies might lead to the reduction of the maternal mortality rate.
Digitally supported HIV self-testing increases facility-based HIV testing capacity in Ekurhuleni, South Africa
Authors: Mshweshwe-Pakela Nolundi T. , Mabuto Tonderai , Shankland Luke , Fischer Alex , Tsukudu Dikeledi , Hoffmann Christopher J. 
Published: June 2022

Background: HIV testing is the first step for linkage to HIV prevention or treatment services. Facility-based HIV testing is the most utilised method, but faces challenges such as limited work space and human resources. Digitally supported HIV self-testing (HIVST) provided in clinics shifts testing to the client, potentially empowering the client, and addresses such constraints.Objectives: The study primary objective was to determine the feasibility of integrating digitally supported HIVST into the clinic. Secondary objectives were to describe HIV testing volume, populations reached, and antiretroviral treatment (ART) initiation.Method: We conducted an analysis of prospectively collected data during implementation of digitally supported HIVST in two healthcare facilities based in South Africa from June 2019 to September 2019. We described implementation and client characteristics using HIVST and compared testing before and during implementation.Results: During the 4-month implementation period there were 35 248 client visits. A total of 6997 (19.9%) of these visits involved HIV testing. Of those testing, 2278 (32.5%) used HIVST. Of the 2267 analysed, 264 (11.6%) were positive: 182 (12%) women and 82 (11%) men. Of those, 230 (95.4%) were confirmed HIV positive and 150 (65%) initiated ART within 14 days. During a four-month pre-implementation period, 14.5% of the clients tested for HIV. Compared to the pre-implementation period, we observed a 25% increase in HIV testing.Conclusion: Digitally supported HIVST increased the number of clients completing HIV testing in the health facility, without a need to significantly increase staff or space. Facility-based digitally assisted HIVST has the potential to increase HIV testing in high HIV prevalence clinic populations.
A diary study of the impression management strategies utilised by industrial and organisational psychology interns
Authors: McGowan Nasreen A. , Sekaja Lusanda 
Published: June 2022

Orientation: When interns enter a new workplace, they are compelled to create and maintain a good impression through a range of image-enhancing behaviours. Impression management strategies can help interns to do this.Research purpose: This study aimed to understand the strategies used by industrial and organisational (I/O) psychology interns, their goals for using them and the targets of these strategies.Motivation for the study: Interns are generally new to the workplace and, as such, may not be aware of how to play the ‘social game’ to create positive impressions about themselves, be perceived in a positive light, gain projects to fulfil their internship requirements, and, where possible, gain full-time employment from the organisation.Research approach/design and method: A qualitative design was used. Data were collected from 14 I/O psychology interns in the form of diary entries and semi-structured interviews.Main findings: The thematic analysis revealed eight key impression management strategies, some existing and others novel: ingratiation, self-promotion, rendering favours, exemplification, professionalism, openness to learning, conformity and building strategic relationships.Practical/managerial implications: Industrial and organisational psychologists should develop workshops to assist interns in using impression management skills to create a positive internship experience and advance in their respective organisations.Contribution/value-add: The study adds theoretically (the study of impression management is relatively new in South Africa), practically (findings may help direct future I/O psychology interns to the correct strategies for creating a positive impression at work) and methodologically (diary studies are not common in qualitative organisational research).
Injury surveillance in community cricket: A new inning for South Africa
Authors: Olivier Benita , Obiora Oluchukwu L. , MacMillan Candice , Finch Caroline 
Published: June 2022

Published injury rates amongst elite and club-level youth cricketers highlight the need to implement injury risk-reducing strategies amongst the youth cricketing population. Data from sports injury surveillance systems are a prerequisite for the development and evaluation of strategies to reduce injury risk. Therefore, collecting injury surveillance data is a positive move towards reducing injuries in cricket. In South Africa, a systematic, standardised, evidence-informed injury surveillance system currently does not exist for community levels of play, namely, in cricket-playing high schools and cricket clubs. Although injury surveillance systems exist at elite levels, the obvious differences in elite versus community cricket settings mean that these systems cannot be implemented in their current form at community-level cricket. An innovative model is required to implement an injury surveillance system in community cricket.Clinical implications: This article proposes and describes a new research–practice partnership model to implement a systematic, standardised, evidence-informed injury surveillance system at cricket-playing high schools or cricket clubs within South Africa. Once this model has been employed, database systems will need to be established to allow long-term data management and sharing.
A Cluster Randomized Trial for Improving Mental Health and Well-Being of Persons Affected by Leprosy or Buruli Ulcer in Nigeria
Authors: Ekeke Ngozi , Ossai Edmund Ndudi , Kreibich Saskia , Onyima Amaka , Chukwu Joseph , Nwafor Charles , Meka Anthony , Murphy-Okpala Ngozi , Henry Precious , Eze Chinwe 
Published: June 2022

This protocol describes a study in which we would assess the effect of using community lay counselors, self-help groups (SHGs), and trained frontline health workers to reduce mental disorders and improve quality of life (QOL) of persons affected by leprosy or Buruli ulcer (BU). A cluster randomized controlled study design will be employed. The study will involve persons affected by leprosy or BU. Ten local government areas (clusters) with the highest number of notified leprosy or BU cases between 2014 and 2018 in Southern Nigeria will be purposively selected. The clusters will be randomized into intervention and control groups using a computer-generated list of random numbers. At baseline, data were collected using the following validated questionnaires, Patient Health Questionnaire, Generalized Anxiety Disorder questionnaire, Stigma Assessment and Reduction of Impact Scale, World Health Organization QOL BREF and Warwick-Edinburgh Mental Well-being scale among persons affected by leprosy or BU. The intervention will last for 2 years and will involve use of community lay counselors, SHGs, and appropriately trained frontline health workers in reducing mental disorders and improving QOL of persons affected by leprosy or BU. This project postulates that the reduction of burden of mental health problems and improved QOL among persons affected by leprosy or BU could be achieved through a holistic approach involving SHGs, appropriately trained community opinion leaders, and general health-care workers as well as a functional referral system. If successful, the model will be integrated into the activities of the National Tuberculosis and Leprosy Control Programme and scaled up nationwide.
Trial registration:
ISRCTN Registry: ISRCTN 83649248.

https://trialsearch.who.int/Trial2.aspx?TrialID%ISRCTN83649248

Prospectively registered.
Knockdown of the Type-II Fatty Acid Synthase Gene hadC in Mycobacterium fortuitum Does Not Affect Its Growth, Biofilm Formation, and Survival under Stress
Authors: Sharma Ayushi , Vashistt Jitendraa , Shrivastava Rahul 
Published: June 2022

Background:
Mycobacterial fatty acid synthase Type-II (FAS-II) components are major virulence factors exploited as potential targets for developing novel antimycobacterial drugs. The FAS-II enzyme 3-hydroxyacyl-ACP dehydratase (HadC) is important for biofilm development and pathogenesis of Mycobacterium tuberculosis and other mycobacterial species.

Methods:
Literature review and homology search led to the identification of Mycobacterium fortuitum MFhadC gene. Functional interaction study of MFHadC protein was done using STRING. M. fortuitum MFhadC over-expressing (HS) and knockdown (HA) strains were constructed and validated by expression analysis using quantitative polymerase chain reaction. The strains were analyzed for growth behavior and surface spreading ability. Biofilm formation was assayed through crystal violet assay, viability count, and basic fuchsin staining. In addition, survival of the strains was studied under in vitro nutrient starvation and detergent stress.

Results:
STRING analysis showed the interaction of HadC with proteins involved in biofilm formation. The strains HS and HA showed spreading ability on the agarose surface, exhibiting translocation patterns similar to the vector control strain. All three strains showed a similar amount of biofilm formation when analyzed using crystal violet assay, viability count, and basic fuchsin staining. The strains showed no deviation in survival when incubated under nutrient starvation and detergent stress.

Conclusion:
Our results suggest that MFhadC may not be important for the formation and maintenance of biofilm, a factor critically important in M. fortuitum pathogenicity. However, not essential for survival and growth, MFhadC maintains the viability of M. fortuitum under a nutrient-starved environment. Collectively, MFhadC may not be used as a biofilm-specific marker for M. fortuitum.
Quality Implications of Regular Versus Overnight Processing of Stored Human Platelets: An Institutional Study
Authors: Das Subhashish , Harendra Kumar M L 
Published: June 2022

ABSTRACT

Background:
Platelet concentrates (PC) are prepared from random donor platelets (RDP) and single donor platelets (SDP) and the various quality parameters of the PC are multifactorial which includes the preparation techniques, types of bags used, holding period prior to processing, type of anticoagulant used, use of additive solutions, the storage conditions after processing, etc. Extending the holding period before processing and ensuring the absence of deleterious affect on the quality parameters of the PC can be extremely beneficial from operational and logistical reasons to meet the increased clinical demand of PCs, particularly for oncology cases and during dengue epidemic.

Aims and Objectives:
The comparative evaluation of various quality parameters including morphological, biochemical and molecular aspects of PCs between fresh whole blood (WB) (8 hrs) versus overnight hold blood (24 hrs) on the 0, 3rd and 5th day of storage.

Materials and Methods:
Fifty units of blood were collected and stored overnight (24 hrs) hours at a temperature of 220C to 240C and processed subsequently. The other 50 units were processed immediately within 8 hours. All the PCs had undergone mandatory serological testing and all the sero-negative PCs had fulfilled quality control parameters. Sterility confirmation was done on 0, 3rd and 5th day of storage. Morphological, biochemical and molecular aspects for both the categories of PCs were studied. For statistical analysis, t-test at 95% confidence interval was done with a P value of <0.05 taken as statistically significant.

Results:
All essential quality parameters in both the categories of PCs were within acceptable limits. No adverse impact on quality was noted in the overnight PCs.

Conclusion:
The preserved quality of overnight PCs along with associated logistic benefits should encourage blood bank management to seriously explore the feasibility of undertaking the 24-hours whole blood holding period (overnight) before preparing PCs.