bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimentally Induced Hyperglycemia in Prepubertal Phase Impairs Oocyte Quality and Functionality in Adult Mice
Authors: Predheepan Dhakshanya , Daddangadi Akshatha , Uppangala Shubhashree , Laxminarayana Sindhura Lakshmi Koulmane , Raval Keyur , Kalthur Guruprasad , Kovačič Borut , Adiga Satish Kumar 
Published: August 2022

Abstract
Reproductive abnormalities in women with a history of childhood diabetes are believed to be partially attributed to hyperglycemia. Prolonged hyperglycemia can negatively affect ovarian function and fertility during reproductive life. To address this in an experimental setting, the present study used streptozotocin-induced hyperglycemic prepubertal mouse model. The impact of prolonged hyperglycemic exposure during prepubertal life on ovarian function, oocyte quality, and functional competence was assessed in adult mice. The ovarian reserve was not significantly altered; however, the in vitro maturation potential (P &lt; 0.001), mitochondrial integrity (P &lt; 0.01), and meiotic spindle assembly (P &lt; 0.05-0.001) in oocytes were significantly affected in hyperglycemic animals in comparison to control groups. The results from the study suggest that prepubertal hyperglycemia can have adverse effects on the oocyte functional competence and spindle integrity during the reproductive phase of life. Because these changes can have a significant impact on the genetic integrity and developmental potential of the embryos and fetus, the observation warrants further research both in experimental and clinical settings.
Can Microbes Be Active Participants in Research? Developing a Methodology for Collaborating with Plastic-Eating Microbes
Authors: Bradshaw Aaron 
Published: August 2022

Abstract
The emergence of Ideonella sakaiensis, a microorganism with the capacity to metabolize the widely used plastic polyethylene terephthalate (PET), raises important questions about how human and nonhuman agency are related in responding to pressing environmental issues. The article explores how the agency and expertise of I. sakaiensis is a constitutive but often overlooked collaborator in scientific research into plastic biodegradation, and it attempts to develop a methodology for enrolling microorganisms as active research participants from the outset. Knowledge coproduced with microbial others, and specifically those microbes with the capacity to detoxify anthropogenic pollutants, may inform and enact inclusive and prescient responses to ongoing environmental degradation. Accordingly, drawing from theoretical orientations in more-than-human participatory research and animals’ geographies, the article asks how microorganisms might express their own directives, preferences, and constraints on the research process, and how, in turn, we might listen and be directed by them. Although the ontological and ethical commitments of the environmental humanities are well suited for welcoming microbes as partners in deliberative processes, the challenges of communicating with them across vast scalar and bodily differences suggests a need to engage with techniques traditionally considered the disciplinary property of the natural sciences. Some of these concepts are contextualized with respect to a research project currently being undertaken at the River Lea in East London and the attempt to enroll I. sakaiensis as a collaborator in responding to plastic pollution in the river.
The Limits of Care
Authors: Di Giminiani Piergiorgio 
Published: August 2022

Abstract
Drawing on the experiences of caring in agriculture and forestry among Mapuche landholders of Chile, this article advances a definition of care as an act of relating intervening mutual articulations of vitality. Caring for nonhumans entails a reflexive awareness of the ontological and ethical limits of human care, limits made visible by the nonhumans’ potentials to respond to our actions and affect us. Reflections on the limits of care foster an attentiveness to the conditions responsible for nonhumans’ ability of enchantment, a term that in Bennett’s proposal concerns an awareness on the singularness and surprising character of life. First, this article characterizes care as a human intentional action targeting dependent nonhumans, such as crops. Second, it illustrates the recalcitrance of some nonhumans to human care, as in the case of forests in Indigenous southern Chile. Third, it shows how care emerges from ethical aspirations and concerns, such as those at the core of Mapuche engagements with cultural reclamation and conservation.
The Indoor People’s Enchanted Ecologies
Authors: Rubow Cecilie 
Published: August 2022

AbstractContrary to the taken-for-granted dictum in nature politics and in public media that “loving nature prompts care,” this article considers less intuitive relations between love and ethics. Through the analysis of different enactments of natures in Denmark and a reading of Jane Bennett’s Enchantment of Modern Life, the article captures how sensibilities and moralities swing from anethical moments to affective forms of responsibility. By comparing walks at a recreational beach with activists’ campaigns at a peri-urban commons and a climate activist march in the capital center, Cecilie Rubow proposes, inspired by Bennett, to think of a variation of chords of wonder and ethics. Dissonantly, the chords of the enchanted ecologies range from magical moments in remote nature to love and respect for co-living plants and animals, and to the perplexing and motivational awareness of one’s entwinement with the whole planet. This reconceptualization of enchantment speaks to the depth of the ecological crises.
Cerebrospinal Fluid Shunting for Idiopathic Intracranial Hypertension: A Systematic Review, Meta-Analysis, and Implications for a Modern Management Protocol
Authors: Salih Mira , Enriquez-Marulanda Alejandro , Khorasanizadeh MirHojjat , Moore Justin , Prabhu Vikram C. , Ogilvy Christopher S. 
Published: August 2022

BACKGROUND:
Cerebrospinal fluid (CSF) shunting is widely used in refractory idiopathic intracranial hypotension (IIH). Although multiple reviews have assessed its efficacy compared with other surgical treatments, there is no detailed analysis that evaluates the clinical outcomes after CSF shunting.

OBJECTIVE:
To conduct a meta-analysis of the clinical impact of CSF shunting for refractory IIH and use this in conjunction with existing information on other treatment modalities to develop a modern management protocol.

METHODS:
PubMed and Embase were systematically searched for studies describing CSF shunting for medically refractory IIH. Relevant information including study characteristics, patient demographics, clinical outcomes, periprocedural complications, and long-term outcomes were subjected to meta-analysis.

RESULTS:
Fifteen studies published between 1988 and 2019 met our inclusion and exclusion criteria, providing 372 patients for analysis. The mean age was 31.2 years (range 0.5-71) with 83.6% being female. The average follow-up was 33.9 months (range 0-278 months). The overall rate of improvement in headache, papilledema, and visual impairment was 91% (95% CI 84%-97%), 96% (95% CI 85%-100%), and 85% (95% CI 72%-95%), respectively. Of 372 patients, 155 had 436 revisions; the overall revision rate was 42% (95% CI 26%-59%). There was no significant correlation between average follow-up duration and revision rates in studies (P = .627). Periprocedural low-pressure headaches were noted in 74 patients (20%; 95% CI 11%-32%).

CONCLUSION:
CSF shunting for IIH is associated with significant improvement in clinical symptoms. Shunting rarely causes periprocedural complications except overdrainage-related low-pressure headache. However, CSF shunting has a relatively high revision rate.
Nanomembranes of Poly(dimethysiloxane) Reinforced with Carbon Nanotubes and Their Potential for CO2 Capture
Authors: Ariyoshi Miho , Fujikawa Shigenori , Kunitake Toyoki 
Published: August 2022

Abstract
Toward CO2 capture from air, highly-permeable nanomembranes of poly(dimethylsiloxane) (PDMS) were mechanically reinforced by thin layers of carbon nanotube (CNT), giving CO2 permeability and gas selectivity of 42,500 GPU and 10 (CO2/N2), respectively in the case of the 27-nm-thick, composite membrane.
Selective Gas Adsorption on Molecular Solids of a Hydrogen-bonding [3.3.3]Propellane
Authors: Kato Kenichi , Hiroi Tatsuki , Seto Nobuyoshi , Ohtani Shunsuke , Ogoshi Tomoki 
Published: August 2022

Abstract
On a rigid three-dimensional π-framework, trinaphtho[3.3.3]propellane, hydrogen-bonding urea moieties were installed by successive functionalization with amino and carbonyl groups. The obtained perimidin-2-one-appended molecule gave void-containing solids without losing intrinsic free volume, being different from precursor molecules. The solids exhibited good adsorption selectivity for ethane, n-butane, and carbon dioxide over methane, because of the cavity surrounded by naphthalene rings and hydrogen-bonding perimidin-2-one units.
Making European performance and impact assessment frameworks for research infrastructures glocal
Authors: Melo Ana M.P. , Oliveira Sofia , Oliveira Jorge S. , Martin Corinne S. , Leite Ricardo B. 
Published: August 2022

Sustainability of research infrastructures (RIs) is a big challenge for funders, stakeholders and operators, and the development and adoption of adequate management tools is a major concern, namely tools for monitoring and evaluating their performance and impact. BioData.pt is the Portuguese Infrastructure of Biological data and the Portuguese node of the European Strategy Forum on Research Infrastructures "Landmark" ELIXIR. The foundations of this national research infrastructure were laid under the “Building BioData.pt” project, for four years. During this period, performance and impact indicators were collected and analysed under the light of international guidelines for assessing the performance and impact of European research infrastructures produced by the European Strategy Forum on Research Infrastructures, the Organisation for Economic Co-operation and Development and the EU-funded RI-PATHS project. The exercise shared herein showed that these frameworks can be adopted by national RIs, with the necessary adaptations, namely to reflect the national landscape and specificity of activities, and can be powerful tools in supporting the management of RIs. “Not everything that counts can be counted, and not everything that can be counted, counts”. (Attributed to William Bruce Cameron)
Analysis of contact tracing surveillance for COVID-19 among healthcare workers in secondary referral hospital, Indonesia
Authors: Asmarawati Tri Pudy , Sukartini Tintin , Ekasari Ardhena , Sofia Devi Rahma , Kamariyah Nurul , Novendrianto Dwiki , Yuliasari Putri , Rusca P Kuswantoro , Acob Joel Rey , Windradi Choirina , Mahdi Bagus Aulia , Martani Okla Sekar , Agustin Esthiningrum Dewi 
Published: August 2022

Background: Healthcare workers (HCWs) are more vulnerable to COVID-19 infection. Tracing and screening cases among healthcare workers are essential to overcome the spread of COVID-19. We held surveillance at the second-referral hospital in Surabaya, Indonesia, to inspect the associating factors of infected HCWs. Methods: From 776 HCWs, we conducted a structured retrospective review of all COVID-19-confirmed HCWs and ones having contact with COVID-19 patients between February-July 2021. We associated general characteristics (i.e age, gender, working sites, etc) of the sample with the positive cases, analyzed the vaccination status, then did bivariate and multivariate regression logistic analyses to determine related factors putting HCWs at risk for COVID-19 infection. Results: Bivariate analysis significantly revealed that 72.86% patients had a close contact (OR = 2.61; p<0.05), with medical staffs as the most frequent source (85.71%; OR = 2.19; p=0.033), for > 15 minutes contact duration (90%; OR = 1.1; p<0.05). Healthcare workers wearing proper PPE (N-95 and face shields) were significantly less exposed to COVID-19 (OR = 0.47; p<0.05; and OR = 0.46; p<0.05). Even fully-vaccinated samples were still prone to infection. (OR=1.25; p= 0.042). Common symptoms consisted of fever, rhinorrhea, sore throat, and vomiting (p=0.025l p=0.002; p<0.05; p=0.002). Multivariate regression logistic analysis disclosed that the use of N95 masks, contact duration >15 minutes, and the vaccine were the most influential factors (aOR = 1.72. 95% CI (1.029-2.88); aOR = 3.92. 95% CI (1.75-8.78); aOR = 0.39. 95% CI (0.13-0.82 )) Conclusions: Close contact, lack of compliance in wearing N95 masks, and unvaccinated status are risk factors for COVID-19 exposure to HCWs; thus, to achieve maximum prevention of intra-hospital transmission, the use of N-95 masks, contact avoidance, and vaccination, along with immediate tracing and strict health-protocols are all compulsory.
An adapted behavioural activation intervention (DiaDeM) for people with diabetes and depression in South Asia: A feasibility study protocol
Authors: Aslam Faiza , Afaq Saima , Siddiqui Faraz , Zavala Gerardo A. , Ahmed Naveed , Walker Simon M. , Maria Jennings Hannah , Fottrell Edward , Ul Haq Zia , Siddiqi Najma , Hewitt Catherine ,   DiaDeM Global Health Research Group
Published: August 2022

Background: The burden of depression is a rapidly growing problem worldwide. Its prevalence is particularly high among individuals with chronic physical conditions such as Type 2 Diabetes (T2DM), precipitating poorer health outcomes. There is a lack of evidence around treatments that can work among such groups, particularly in Low and Middle-Income Countries (LMICs). This study aims to test the feasibility and acceptability of a culturally adapted Behavioural Activation (BA) intervention (DiaDeM) for people with T2DM and depression in two LMICs in South Asia. Methods: A multicentre, randomised-controlled feasibility trial will be conducted from March 2022 to February 2023. We will recruit 128 adults from health facilities in Bangladesh and Pakistan with a diagnosis of T2DM and depression. Using a 1:1 allocation ratio, consenting individuals will be randomised to either optimised usual care or the DiaDeM intervention. The latter will involve six face-to-face or remotely delivered BA sessions conducted by non-mental health facilitators over six to twelve weeks. Participants will be followed up at three and six months post-randomisation. Feasibility outcomes include the feasibility and acceptability of recruitment and retention, the feasibility of intervention delivery and the feasibility of data collection at baseline and follow-up (including economic data). An embedded mixed-methods process evaluation will also be carried out to inform the main trial. Conclusions: BA is a low resource intervention for depression treatment that can be optimised for delivery in LMIC settings such as South Asia. The planned feasibility trial will directly inform a larger trial to assess the effectiveness and cost-effectiveness of such an intervention in people with T2DM and depression. It will also contribute to the wider evidence base around BA in patients with chronic physical illnesses, with particular relevance to South Asian, as well as wider LMIC regions and populations. Trial registration: ISRCTN 75501608
The Wessex Fit-4-Cancer Surgery Trial (WesFit): a protocol for a factorial-design, pragmatic randomised-controlled trial investigating the effects of a multi-modal prehabilitation programme in patients undergoing elective major intra–cavity cancer surgery
Authors: West Malcolm , Bates Andrew , Grimmett Chloe , Allen Cait , Green Richard , Hawkins Lesley , Moyses Helen , Leggett Samantha , Z H Levett Denny , Rickard Sally , Varkonyi-Sepp Judit , Williams Fran , Wootton Stephen , Hayes Matthew , P W Grocott Micheal , Jack Sandy 
Published: August 2022

Background: Surgical resection remains the primary curative treatment for intra-cavity cancer. Low physical fitness and psychological factors such as depression are predictive of post–operative morbidity, mortality and length of hospital stay. Prolonged post-operative morbidity is associated with persistently elevated risk of premature death. We aim to investigate whether a structured, responsive exercise training programme, a psychological support programme or combined exercise and psychological support, delivered between treatment decision and major intra-cavity surgery for cancer, can reduce length of hospital stay, compared with standard care. Methods: WesFit is a pragmatic, 2x2 factorial-design, multi-centre, randomised-controlled trial, with planned recruitment of N=1560. Participants will be randomised to one of four groups. Group 1 (control) will receive usual pre-operative care, Group 2 (exercise) patients will undergo 2/3 aerobic, high-intensity interval training sessions per week supervised by personal trainers. Group 3 (psychological support) patients are offered 1 session per week at a local cancer support centre. Group 4 will receive both exercise and psychological support. All patients undergo baseline and pre-operative cardiopulmonary exercise testing, complete self-report questionnaires and will be followed up at 30 days, 12 weeks and 12 months post-operatively. Primary outcome is post-operative length-of-stay. Secondary outcomes include disability-adjusted survival at 1-year postoperatively, post-operative morbidity, and health-related quality of life. Exploratory investigations include objectively measured changes in physical fitness assessed by cardiopulmonary exercise test, disease-free and overall mortality at 1-year postoperatively, longer-term physical activity behaviour change, pre-operative radiological tumour regression, pathological tumour regression, pre and post-operative body composition analysis, health economics analysis and nutritional characterisation and its relationship to post-operative outcome. Conclusions: The WesFit trial will be a randomised controlled study investigating whether a high-intensity exercise training programme +/- psychological intervention results in improvements in clinical and patient reported outcomes in patients undergoing major inter-cavity resection of cancer. ClinicalTrials.gov registration: NCT03509428 (26/04/2018)
INCP procedures in a patient with lung cancer
Authors: Gdowska Kinga , Mess Eleonora 
Published: August 2022

Lung cancer is the most common malignant tumour in Poland and the first cause of death
among oncological diseases. This article presents the main factors causing lung cancer, the course
of the disease and health consequences. The most important nursing problems have been identified,
taking into account the individual nursing plan. Nursing actions were proposed to adapt the patient
to the new situation, to improve his physical and psychological condition and to educate the patient
and his family.
Repeated Games with Incomplete Information over Predictable Systems
Authors: Lehrer Ehud , Shaiderman Dimitry 
Published: August 2022

Consider a stationary process taking values in a finite state space. Each state is associated with a finite one-shot zero-sum game. We investigate the infinitely repeated zero-sum game with incomplete information on one side in which the state of the game evolves according to the stationary process. Two players, named the observer and the adversary, play the following game. At the beginning of any stage, only the observer is informed of the state ξn and is therefore the only one who knows the identity of the forthcoming one-shot game. Then, both players take actions, which become publicly known. The paper shows the existence of a uniform value in a new class of stationary processes: ergodic Kronecker systems. Techniques from ergodic theory, probability theory, and game theory are employed to describe the optimal strategies of the two players. Funding: This work was supported by the Israel Science Foundation [Grant 591/21] and Deutsche Forschungsgemeinschaft [Grant KA 5609/1-1].
The Factor of Association of Diabetes Knowledge in Diabetes Mellitus type 2 patients
Authors: Sangruangake Monthida , Srisuwan Ponpimon , Ruangsuksud Piches , Solikhah Solikhah , Sungworawongpana Thiti 
Published: August 2022

Background: T2DM is a chronic illness associated with numerous comorbidities and leads to chronic complications, resulting in high morbidity and mortality, rising health care costs. However, patients with this disease, through self-care, can significantly mitigate the risk, or delay the onset of these T2DM complications Objective: To investigate factors along with Diabetes Knowledge Method: A cross-sectional study was carried out among T2DM patients living in both rural and urban areas from the Central and Northeastern regions of Thailand were recruited from outpatient diabetes clinics of both community and university hospitals in both the Khon Kaen and Bangkok provinces of Thailand. Patients were sampled using a stratified sampling design where strata were based on locality (Province) - hospital size combinations. Firstly, we had translated all questionnaires from English to the local language then again back translated simultaneously. Then, the third step was to perform psychometric testing of the DK instrument Lastly, binary logistics mixed effect regression was used to investigate the clustering effect of the participant’s characteristic on this study. Results: After adjust for covariates derivate that age, KK and smaller hospitals, higher education, monthly income, underweight and overweight, DM treatment, and smoking nor alcohol where all found to be associated with various DK Conclusion: In future DK measurement is likely to provide valuable insights in to the epidemiology of diabetes self-management and may also be used to evaluate interventions to reduce poor self-care in T2DM patients, in turn, politically reducing the incidence of, and mortality from, type 2 diabetes mellitus complications.
Prevalence of violence and associated factors among youth in Northwest Ethiopia: Community-based cross-sectional study
Authors: Geremew Alehegn Bishaw , Gelagay Abebaw Addis , Bisetegn Telake Azale , Habitu Yohannes Ayanaw , Abebe Solomon Mekonen , Birru Eshetie Melese , Mengistu Temiro Azanaw , Ayele Yilikal Tiruneh , Yeshita Hedija Yenus 
Published: August 2022

Background
Violence as a known serious public health problem affects people in all stages of life, from childhood to the elderly. In society, one of the most visible forms of violence is young people violence, whereas they, adolescents and young adults, are the main victims of such violence. There was limited information on the burden of violence and factors among this age group. Therefore, this study aimed to determine the prevalence of violence and its associated factors among youth in Northwest, Ethiopia.

Methods
A community-based cross-sectional study design was conducted to estimate the magnitude of violence among youth in Northwest, Ethiopia. Data were taken from the mega project entitled assessment of common health problem and risky health behavior among youth. Youth violence was the dependent variable whereas the socio-demographic variables and substance use were the independent-variables. The bivariate logistic regression model was employed to identify associated factors. An adjusted odds ratio with a 95% confidence interval was used to determine factors associated with violence.

Results
From the total 1765 representatives of the youth population,1597 (90.5%) youth participated in the study. Overall, the prevalence of violence among youth aged 15–24 years for the last 12 months was 21.5%. In the multivariable logistic regression model, factors significantly associated with violence were being married and divorced (AOR = 1.77, 95%CI: 1.13, 2.79) and (AOR = 5.67, 95%CI: 2.93, 10.99), respectively, living with mother’s only (AOR = 1.85,95%CI: 1.28, 2.66) and father’s only (AOR = 2.45, 95% CI: 1.30, 4.63), and substance use (AOR = 2.38,95% CI: 1.56, 3.66).

Conclusions
The prevalence of violence among youth was high compared to other studies. Special emphasis Should be given for youth violence in order to manage the victims as well as for preventing and controlling the identified factors through strengthening policies and strategies.