bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arteriosklerose und Knochendichte – Arterielle Kalzifikationen in der hochauflösenden, peripheren quantitativen Computertomographie
Authors: Bartosik Mikolaj , Schmidt Felix N 
Published: December 2022

ZusammenfassungAufgrund der Gemeinsamkeit eines mineralisierten Gewebes sowohl im Falle des Knochens (mineralisiertes Osteoid) als auch bei Arteriosklerose (Mineralisation im Bereich des Endothels bei chronischer Entzündungsreaktion) und verwandter biochemischer Mechanismen wird seit geraumer Zeit ein Zusammenhang zwischen Arteriosklerose und der Knochenstruktur und -mineralisation vermutet. Eine abnehmende Knochendichte in der Knochendichtemessung (DXA) konnte parallel zu einem gehäuften Auftreten einer Arteriosklerose gezeigt werden, eine Kausalität konnte bis heute nicht geklärt werden. Die hochauflösende, periphere, quantitative Computertomographie (HR-pQCT) bietet die Möglichkeit die Kalzifikation der Arterien der unteren Extremität im Scanvolumen zu detektieren und quantifizieren. Hierbei treten Gefäßkalzifikationen nebenbefundlich in Abhängigkeit der Grunderkrankung bei 32,6% der Patienten ohne Grunderkrankung auf. Bei weiblichen Patient:innen ohne Grunderkrankung konnte im Gegensatz zu Männern eine gleichzeitige Abnahme einzelner kortikaler und trabekulärer HR-pQCT-Parameter bei vermehrtem Auftreten einer LLAC beobachtet werden. Bei einer CKD lässt sich parallel zum vermehrten Auftreten einer LLAC ein kortikales Knochenstrukturverlustsyndrom feststellen, wobei CKD-Patienten mit LLAC signifikant geminderte Werte im Vergleich zu CKD-Patienten ohne LLAC aufwiesen. Auch beim Hypoparathyreoidismus zeigen sich eine Häufung der LLAC im HR-pQCT im Vergleich zu einer Kontrollgruppe. Somit zeigt sich der Einfluss einer Dysbalance der Calciumhomöostase auf die Mineralisation beider Gewebe und unterstreicht die hohe Bedeutung einer Balancierung der Calciumhomöostase. Dieser Artikel stellt die bisherigen Erkenntnisse und Zusammenhänge der Arteriosklerose mit osteologischen Aspekten im Sinne der Knochenmikrostruktur und weiterer Parameter vor.
Zöliakie
Authors: Laaß Martin W. 
Published: December 2022

ZUSAMMENFASSUNGDie Zöliakie kann sich beim Kleinkind klassisch mit einer chronischen Diarrhö, Zeichen der Malabsorption und einer Gedeihstörung manifestieren. Je älter die Betroffenen aber sind, um so unspezifischer und unbemerkbarer können die Symptome sein. Bei Verdacht auf eine Zöliakie werden primär die Gewebstransglutaminase-2 (TG2)-IgA-Antikörper und das Gesamt-IgA im Serum bestimmt. Bei erniedrigtem IgA im Serum sollte ein zöliakiespezifischer IgG-Antikörper angefordert werden. Wenn die Antikörper gegen TG2 erhöht sind, kann zur Diagnosesicherung eine Endoskopie mit mindestens 6 Biopsien aus allen Abschnitten des Duodenums notwendig sein. Für den Fall jedoch, dass die TG2-IgA-Antikörper über dem Zehnfachen des Testgrenzwertes gemessen wurden, kann angeboten werden, die Diagnose Zöliakie auch ohne histologische Sicherung zu stellen. Dafür müssen aber auch die Endomysium-IgA-Antikörper in einer zweiten Blutentnahme erhöht und ein Aufklärungsgespräch eines Kindergastroenterologen mit den Sorgeberechtigten und dem betroffenen Kind erfolgt sein. Eine lebenslange streng glutenfreie Diät ist nach wie vor die einzige und zugleich beste und wirksamste Therapie.
Vergleichende Langzeitergebnisse zwischen Tibial Plateau Leveling Osteotomy und Modified Maquet Procedure nach Ruptur des vorderen Kreuzbandes beim Hund
Authors: Trillig Lukas , Eberle Daniela , Reese Sven , Meyer-Lindenberg Andrea 
Published: December 2022

Zusammenfassung
Gegenstand und Ziel Ziel dieser Studie ist es, die Modified Maquet Procedure (MMP) mit der Tibial Plateau Leveling Osteotomy (TPLO) anhand von Langzeitkontrollen über ein Jahr (∅ 3,15 Jahre) mittels klinischer Untersuchung, röntgenologischer Beurteilung der Arthroseprogression und Ganganalyse durch Laufbanduntersuchung zu vergleichen. Zusätzliches Ziel ist es, den Einfluss der Erfahrung der Chirurgen bei der TPLO-Technik zu überprüfen.
Material und Methoden Bei dieser klinischen Studie wurden 67 Kniegelenke von 50 Hunden verschiedener Rassen zwischen 20 und 40 Kilogramm Körpergewicht einbezogen, die mittels TPLO beziehungsweise MMP (n = 19) nach Ruptur des vorderen Kreuzbandes operiert wurden. Die TPLO-Gruppe unterteilte sich in eine Gruppe, welche von 2 erfahrenen Chirurgen (TPLO1, n = 25) operiert wurde und eine zweite Gruppe, die von mehreren Chirurgen unterschiedlicher Erfahrung (TPLO2, n = 23) versorgt wurden. Die Hunde wurden nach mindestens über einem Jahr (3,15 ± 1,21 Jahre) postoperativ orthopädisch, röntgenologisch und ganganalytisch uni- und bilateral getrennt untersucht. Zusätzlich wurden die Daten der Ganganalyse mit einer orthopädisch gesunden Kontrollgruppe verglichen.
Ergebnisse Bei der orthopädischen Untersuchung wurden keine signifikanten und klinisch relevanten Unterschiede zwischen den 3 Gruppen festgestellt.Die Arthroseprogression zeigte in allen 3 OP-Gruppen ähnliche Werte, wobei die der TPLO2-Gruppe durchschnittlich pro Jahr gerechnet signifikant etwas geringer war als die der TPLO1- und der MMP-Gruppe.Die ganganalytische Untersuchung im Schritt konnte vor allem im Vergleich mit der gesunden Kontrollgruppe signifikante Unterschiede bei bilateralen Rupturen für die Peak Vertical Force und den Vertical Impulse zeigen. Die Standphasendauer wies keine signifikanten Unterschiede auf. Im Trab konnten keine signifikanten Unterschiede zwischen den 3 OP-Gruppen festgestellt werden.
Schlussfolgerung Beide Operationstechniken erzielten in den 3 Gruppen bei den Langzeitkontrollen gute klinische, radiologische und ganganalytische Ergebnisse auch im Vergleich mit einer gesunden Kontrollgruppe.
Klinische Relevanz Die MMP kann als schnell durchführbare Alternative zur etablierten TPLO mit ebenfalls guten Ergebnissen beim Hund angesehen werden. Die Erfahrung des Chirurgen scheint keinen Einfluss auf das Ergebnis zu haben.
Ein Update zur Leishmaniose des Hundes: Diagnostik, Therapie und Monitoring
Authors: Schäfer Ingo , Müller Elisabeth , Naucke Torsten J. 
Published: December 2022

ZusammenfassungAufgrund von steigenden Importzahlen von Hunden aus dem Ausland, zunehmendem Reiseverkehr sowie den Veränderungen klimatischer Bedingungen in Europa gewinnen Infektionen mit Leishmania (L.) infantum bei Hunden in Deutschland zunehmend an Bedeutung. Daher sollten auch Hunde aus dem Ausland, die keine klinischen Symptome zeigen, direkt nach Import sowie erneut 6 Monate später auf vektorübertragene Infektionserreger getestet werden. Bei Hunden mit klinischer Symptomatik, die hinweisend auf eine Leishmaniose sind, werden direkte und indirekte Nachweisverfahren sowie eine hämatologische und biochemische Untersuchung unter Einbezug von Serumeiweißelektrophorese sowie Bestimmung des C-reaktiven Proteins empfohlen. Als Leitfaden für die Therapie sowie das Monitoring stehen die LeishVet-Guidelines zur Verfügung. Es stehen leishmanizide und leishmaniostatische Wirkstoffe zur Verfügung, die in first-line, second-line und third-line unterschieden werden. Zur Anpassung der Allopurinol-Dosierung wird der Stufenplan empfohlen. Aufgrund der Veränderung der klimatischen Bedingungen kommt es zu einer Ausbreitung der Habitate von Sandmücken, die als Vektoren der Leishmaniose bekannt sind. Als weitere Infektionsquellen sind Deckakte, transplazentare Infektionen, Bisswunden und Bluttransfusionen beschrieben. Leishmania infantum hat zoonotisches Potential und ist daher auch in Hinblick auf den „One-Health“-Gedanken bedeutend.
Surface Roughness and Hardness of CAD/CAM Ceramic Materials after Polishing with a Multipurpose Polishing Kit: An In Vitro Study
Authors: Limpuangthip Nareudee , Poosanthanasarn Ekaluck , Salimee Prarom 
Published: December 2022

Abstract
Objective This article evaluates the effect of multipurpose polishing kit on surface roughness and hardness of three computer-aided design/computer-aided manufacturing (CAD/CAM) ceramic materials at different polishing durations. Weight changes of the polishing bur were also determined.
Material and Methods Three CAD/CAM ceramic materials were lithium disilicate glass ceramic (IPS e.max CAD), translucent zirconia (VITA YZ), and zirconia-reinforced lithium disilicate ceramic (Celtra Duo). Ceramics were ground with a diamond bur, and polished with the multipurpose polishing kit (Eve Diacera HP), which comprises coarse and fine polishing burs. Surface roughness value (Ra) was measured using a noncontact optical profilometer (n = 10 per group) after grinding and every 15 seconds of coarse and fine polishing until 60 seconds. The complete polishing Ra was compared with the lab as-received specimens and human enamel. Surface morphology was examined using a scanning electron microscope after 60-second coarse and fine polishing and compared with the lab as-received specimens. Hardness was measured using a Vickers hardness tester on the lab as-received specimens and after the final polishing process (n = 4 per group). Changes in surface roughness and polishing bur weight of each material were analyzed using one-way repeated-measures analysis of variance (ANOVA) and dependent t-test. One-way ANOVA was used to detect differences in surface roughness, Vickers hardness, and bur weight among materials within the same polishing duration (α = 0.05).
Results From grinding to complete polishing, the greatest Ra reduction was found in VITA YZ, followed by Celtra Duo and IPS e.max CAD. Final Ra values of all ceramics after 60-second fine polishing were not significantly different, and were similar to that of enamel and lab as-received specimens. Vickers hardness of ceramic materials did not change after grinding and polishing. Coarse polishing bur demonstrated the highest weight loss after polishing VITA YZ, followed by Celtra Duo and IPS e.max CAD.
Conclusion The multipurpose polishing kit reduced surface roughness of CAD/CAM ceramic materials to the similar level of the lab as-received specimen and enamel regardless of material's hardness. The reductions of surface roughness and a coarse polishing bur weight were highest in VITA YZ, followed by Celtra Duo and IPS e.max CAD.
Eating Behavior and Caries Experience in Children with Growth Stunting
Authors: Sari Regina Puspita , Rahayuwati Laili , Setiawan Arlette Suzy 
Published: December 2022

Abstract
Objective Stunting is the impaired growth and development children experience from chronic malnutrition and repeated infection that cause long-term damage. Malnutrition for a long time will affect the shape and composition of bones and teeth, making children more vulnerable to dental health problems. Preschoolers with sufficiently active consumption can choose the food they like delightful foods so that it can increase the risk of caries. Based on data from the Bandung City Health Office in 2019, 161 toddlers (25.43%) in Sukawarna Village experienced stunting. This study analyzed the relationship between eating behavior and caries experience in stunting children in Sukawarna Village, Sukajadi District.
Materials and Methods This study uses a quantitative descriptive research method with a secondary data analysis approach from the documentation of the Universitas Padjadjaran Academic Leadership Grant data with the title “Aspects of jaw growth-development and family approach in early detection and prevention of stunting.” Sampling used purposive sampling specifically for preschool children with a sample size of 80 respondents. The data obtained will be processed and then analyzed using the Spearman Rank correlation statistical test.
Results Sixty-three percent of respondents have poor eating behavior, and the majority (80.35%) have cavities due to caries (decay). Spearman Rank correlation coefficient is −0.145 and significance is 0.0983.
Conclusion Overall eating behavior is related to the caries experience in stunting children. Consumption of cariogenic foods influences the caries experience.
Vibrational Force on Accelerating Orthodontic Tooth Movement: A Systematic Review and Meta-Analysis
Authors: Akbari Amin , Gandhi Vaibhav , Chen Jie , Turkkahraman Hakan , Yadav Sumit 
Published: December 2022

AbstractThis study aimed to systematically gather and analyze the current level of evidence for the effectiveness of the vibrational force in accelerating orthodontic tooth movement (OTM). This systematic review was conducted using three electronic databases: Scopus, PubMed, and Google Scholar until March 2022. The search was done through the following journals: European Journal of Orthodontics, American Journal of Orthodontics and Dentofacial Orthopedics, The Angle Orthodontist, Progress in Orthodontics, and Seminars in Orthodontics. Human or animal studies that have evaluated the effect of vibrational force on the rate of OTM were selected. A meta-analysis was performed for the rate of canine movement per month. Database research, elimination of duplicate studies, data extraction, and risk of bias assessment were performed by authors independently and in duplication. A fixed and random-effect meta-analysis was performed to evaluate the effect of vibrational forces. A total of 19 studies (6 animal and 13 human studies) that met the inclusion criteria were included. Meta-analysis was performed based on four human clinical trials. Three out of four studies showed no significant difference in the rate of canine movement between vibrational force and control groups. The limitation of this study was the small sample size and significant heterogeneity among the studies. Although vibrational forces have been shown to accelerate OTM in experimental studies, the results are inconsistent in clinical studies. The inability to apply desired peak load to the targeted teeth may be the main factor in inconsistent clinical outcomes.
Exosomal microRNAs Targeting TP53 Gene as Promising Prognostic Markers for Head and Neck Squamous Cell Carcinoma
Authors: Jayaseelan Vijayashree Priyadharsini , Arumugam Paramasivam 
Published: December 2022

Abstract
Statement of Problem MicroRNAs are small non-coding RNAs that regulate an array of functions by targeting crucial genes. A significant dysregulation in the TP53 profile has been observed in the head and neck squamous cell carcinoma (HNSCC) patients. Hence, the present in silico study was designed to identify those microRNAs which target TP53 gene and demonstrate their differential expression in HNSCC cases.
Materials and Methods The study was extended further to explore their exosomal location using database such as EVmiRNA and ExoCarta. The study follows an observational in silico design. Computational tool miRDB was used identify the microRNA targets of TP53 gene. The UALCAN server was used to ascertain the expression of microRNA in HNSCC cases derived from the Cancer Gene Atlas dataset. The survival of HNSCC patients based on the differential expression microRNA markers were recorded. Further, each of the microRNA was queried for their exosomal presence using EVmiRNA.
Results About 102 microRNA targets of TP53 gene with a target score in the range of 95–50 were identified. The differential expression data for 52 microRNAs was retrieved from the UALCAN database. The microRNAs hsa-miR-421, hsa-miR-548f-5p, and hsa-let-7c-5p were found to be differentially expressed with marked influence over the survival of HNSCC patients. Furthermore, hsa-miR-421 and hsa-let-7c-5p were found to have an exosomal origin especially in body fluids such as blood and saliva.
Conclusion The results accumulated from the present study identified three microRNAs which can affect the functions of TP53 gene and bring about serious outcomes in HNSCC patients. The microRNAs of exosomal origin targeting TP53 gene in HNSCC patients can be a promising prognostic marker, which can be further used as a therapeutic lead by designing inhibitors.
Preventing Teratogenicity in Women with Epilepsy
Authors: Kinney Michael O. , Smith Phil E. M. , Craig John J. 
Published: December 2022

AbstractOver the last 50 years there has been a significant increase in our understanding of the issues faced by women with epilepsy, in both planning and undertaking pregnancy. The risks of teratogenicity associated with antiseizure medications have emerged slowly. The major pregnancy registers have substantially contributed to our knowledge about teratogenic risk associated with the commonly used antiseizure medications. However, there are substantial gaps in our knowledge about the potential risks associated with many third-generation drugs. The remit of the pregnancy registers and the wider research focus has moved beyond anatomical major congenital malformations. Increasingly neurodevelopmental and behavioral abnormalities have been investigated after in utero exposure to antiseizure medications. Public health approaches can help reduce the risk of teratogenicity. However, neurologists still have a vital role in reducing the risk of teratogenicity at an individual level for women attending their clinic. They also have responsibility to ensure that women with epilepsy are aware of the rationale for the different available options.
Finite features of quantum de Sitter space
Authors: Anninos Dionysios , Galante Damián A , Mühlmann Beatrix 
Published: December 2022

AbstractWe consider degrees of freedom for a quantum de Sitter spacetime. The problem is studied from both a Lorentzian and a Euclidean perspective. From a Lorentzian perspective, we compute dynamical properties of the static patch de Sitter horizon. These are compared to dynamical features of a black hole. We point out differences suggestive of non-standard thermal behaviour for the de Sitter horizon. We establish that geometries interpolating between an asymptotically AdS2×S2space and a dS4interior are compatible with the null energy condition, albeit with a non-standard decreasing radial size ofS2. The putative holographic dual of an asymptotic AdS2spacetime is comprised of a finite number of underlying degrees of freedom. From a Euclidean perspective we consider the gravitational path integral for fields over compact manifolds. In two-dimensions, we review Polchinski’s BRST localisation of Liouville theory and propose a supersymmetric extension of timelike Liouville theory which exhibits supersymmetric localisation. We speculate that localisation of the Euclidean gravitational path integral is a reflection of a finite number of degrees of freedom in a quantum de Sitter Universe.
Impact of CH4 addition on the electron properties and electric field dynamics in a Ar nanosecond-pulsed dielectric barrier discharge
Authors: Chen Timothy Y , Mao Xingqian , Zhong Hongtao , Lin Ying , Liu Ning , Goldberg Benjamin M , Ju Yiguang , Kolemen Egemen 
Published: December 2022

Abstract
Non-equilibrium plasmas derive their low temperature reactivity from producing and driving energetic electrons and active species under large electric fields. Therefore, the impact of reactants on the plasma properties including electron number density, electric field, and electron temperature is critical for applications such as plasma methane (CH

4

)

reforming. Due to experimental complexity, electron properties and the electric field are rarely measured together in the same discharge. In this work, we combine time-resolved Thomson scattering and electric field induced second harmonic generation to probe electron temperature, electron density, and electric field strength in a 60 Torr CH4/Ar nanosecond-pulsed dielectric barrier discharge while varying the CH4 mole fraction from 0% to 8%. These measurements are compared to a 1D numerical model to benchmark its predictions and identify areas of uncertainty. Nonlinear coupling between CH4 addition, electron temperature, electron density, and the electric field was directly observed. Contrary to previous measurements in He, the electron temperature increased with CH4 mole fraction. This rise in electron temperature is identified as electron heating by residual electric fields that increased with larger CH4 mole fraction. Moreover, the electron number density has been found to decrease rapidly with the increase of methane mole fraction. Comparison of these measurements with the model yielded better agreement at higher CH4 mole fractions and with the usage of ab initio calculated Ar electron-impact cross-sections from the B-spline R-matrix database. Furthermore, the calculated plasma properties are shown to be sensitive to the residual surface charge implanted on the quartz dielectric surfaces. Without considering surface charge in the simulations, the calculated electric field profiles agreed well with the measurements, but the electron properties were underpredicted by more than a factor of three. Therefore, measurements of either the electric field or electron properties measurements alone are insufficient to fully validate modeling predictions.
Dual- luminophore efficient luminescent solar concentrator fabricated by low-cost 3D printing
Authors: Ebrahimisadr Saeid , Olyaeefar Babak , Ahmadi-kandjani Sohrab 
Published: December 2022

Abstract
Luminescent Solar Concentrators (LSCs), as cost-effective optical devices for photon concentration, have been showing promising applications in photovoltaic systems. Recently, LSCs are being fabricated through different methods to improve their performance and reduce the cost of fabrication. One of the most common and traditional methods of LSC fabrication is Free Radical Polymerization. In which free radicals are formed through thermal decomposition or photolysis of radical initiators. This research work introduces 3D printed LSCs based on CsPbBr3/Cs4PbBr6 Perovskite Nanocrystals (NCs) and an organic Rhodamine b luminophore mixtures. Nowadays, 3D printing technology has a wide variety of applications in industry, medicine, education, etc. 3D printing technique due to the cheap and accessible raw materials is proved to be a facile and cost-effective method to fabricate LSCs. CsPbBr3/Cs4PbBr6 Perovskites were synthesized using a modified reverse microemulsion method. Poly Lactic Acid (PLA) granules with a luminophore concentration of 0.001 wt% were used to fabricate 3D Printer filament as a polymer for LSC fabrication. XRD, FE-SEM, and EDS analysis were applied to synthesized Perovskites to prove formation of CsPbBr3/Cs4PbBr6 Perovskites. Absorption and Photoluminescence spectrum of used luminophores in LSCs were investigated. Re-absorption effect and I–V plots of prepared LSCs were studied. The I–V plot of the attached solar cell to pristine PLA and luminophore dispersed LSCs shows that the solar cell attached to the dual-luminophore LSC is approximately 122% more efficient than the one attached to pristine PLA LSC.
Thermomagnetic instabilities in 3D network of superconducting lead nanofilaments in porous glass
Authors: Shitov A E , Mikhailin N Y , Kumzerov Y A , Shamshur D V , Volkov M P 
Published: December 2022

Abstract
Thermomagnetic instabilities in the lead-porous glass (Pb-PG) nanocomposite in superconducting state were studied, and a model was proposed that relates magnetization jumps and heat release spikes with average critical current density. The samples were created by filling porous glass (characteristic pore size d = 7 nm) with lead from a melt under pressure, which created a 3D multiply connected system of lead filaments. The critical temperature of superconducting transition in Pb-PG T

c
= 7.2 K is the same as for bulk lead and the critical magnetic field H

c
(0) ≈ 40 kOe is much higher than H

c

bulk
(0) ≈ 800 Oe for bulk lead. Hysteresis and magnetic flux jumps were observed in the magnetization curves m(H) of the Pb-PG nanocomposite, which are connected with the formation of magnetic flux gradients in a system of interconnected contours. Magnetic flux jumps are thermomagnetic processes accompanied by heat release which was directly observed by measuring adiabatic temperature change in the sample during magnetic field sweep. The flux jumps in the magnetization and heat release events were almost periodic in the magnetic field. The period dependences on the magnetic field are similar to the calculated average critical current density dependence j

c

(H).