bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mothers’ and fathers’ stress and severity of depressive symptoms during the COVID-19 pandemic: actor-partner effects with parental negative emotions as a moderator
Authors: Cheung Rebecca Y. M. , Cheng Wing Yee , Li Jian-Bin , Lau Eva Yi Hung , Chung Kevin Kien Hoa 
Published: December 2022

AbstractBackgroundIn the face of the coronavirus disease 2019 (COVID-19) pandemic, families with young children are bombarded with new challenges and stressors. This study examined the additive and interactive effects of parental stress and negative emotions during COVID-19 on parents’ severity of depressive symptoms.MethodsParticipants were 221 Chinese families involving maritally intact mothers and fathers of preschool-aged children.DiscussionPath analysis indicated that mothers’ parental stress interacted with their negative emotions, such that their stress was related to their severity of depressive symptoms only when negative emotions were high. By comparison, fathers’ stress and negative emotions were additively associated with their severity of depressive symptoms. Supporting the cumulative risk model, parental stress during COVID-19 and negative emotions were linked to parents’ severity of depressive symptoms additively or interactively, depending on the gender of the parent. These findings inform practitioners about the relevance of parents’ stress and negative emotions to their severity of depressive symptoms during the pandemic.
Decision support software-guided medication reviews in elderly patients with polypharmacy: a prospective analysis of routine data from community pharmacies (OPtiMed study protocol)
Authors: Maierhöfer Stefan , Waltering Isabell , Jacobs Mareike , Würthwein Gudrun , Appelrath Meike , Koling Susanne , Hempel Georg 
Published: December 2022

Abstract
Background
Pharmacist-led medication reviews are considered a valuable measure to address risks of polypharmacy. The software Medinspector® is used in community pharmacies to assist the performance of this complex service by structuring the medication review process and supporting pharmacists in their decision-making with targeted clinical knowledge. Key feature is a computerized risk assessment of both the initial and adjusted medication regimen of a patient in multiple domains, thus aiming to support the identification and solving of drug-related problems. This study will examine the effects of medication reviews performed with the clinical decision support system in daily routine practice on medication-related and patient-reported outcomes in elderly patients with polypharmacy.

Methods
A prospective, before–after observational study is conducted in German community pharmacies aiming to include 148 patients aged 65 or older, who chronically use five or more active pharmaceutical substances with systemic effects and utilize the software-supported medication review service. The study is based on routine documentation within the software over the course of the medication review, including a patient’s baseline medication, the medication proposed by pharmacists, and the final medication regimen. A software-implemented questionnaire comprising self-developed and literature-derived instruments is used to collect patient-reported outcome data at baseline and follow-up. Primary outcome is the appropriateness of medication measured with an adapted version of the Medication Appropriateness Index (MAI). Secondary medication-related outcomes are medication underuse, exposition towards anticholinergic/sedative drugs, number of drugs in long-term use and the implementation of pharmacist-proposed medication adjustments by the physicians. Secondary patient-reported outcomes are symptom burden, medication-related quality of life, adherence, fulfillment of medication review-related goals, and perception of the service.

Discussion
With the recently introduced remuneration of community pharmacist-led MR in Germany, the demand for digital tools supporting the MR process is assumed to rise. The OPtiMed-study is expected to create evidence on the effects of a novel tool on patient care in a vulnerable patient population.
Trial registration German Clinical Trials Register, DRKS00027410. Registered 22 December 2021, https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00027410. Also available on the WHO meta-registry: https://trialsearch.who.int/?TrialID=DRKS00027410
The PerPAIN trial: a pilot randomized controlled trial of personalized treatment allocation for chronic musculoskeletal pain—a protocol
Authors: Beiner E. , Baumeister D. , Buhai D. , Löffler M. , Löffler A. , Schick A. , Ader L. , Eich W. , Sirazitdinov A. , Malone C. , Hopp M. , Ruckes C. , Hesser J. , Reininghaus U. , Flor H. , Tesarz J. ,   PerPAIN consortium
Published: December 2022

Abstract
Background
The therapy of chronic musculoskeletal pain (CMSP) is complex and the treatment results are often insufficient despite numerous therapeutic options. While individual patients respond very well to specific interventions, other patients show no improvement. Personalized treatment assignment offers a promising approach to improve response rates; however, there are no validated cross-disease allocation algorithms available for the treatment of chronic pain in validated personalized pain interventions. This trial aims to test the feasibility and safety of a personalized pain psychotherapy allocation with three different treatment modules and estimate initial signals of efficacy and utility of such an approach compared to non-personalized allocation.

Methods
This is a randomized, controlled assessor-blinded pilot trial with a multifactorial parallel arm design. CMSP patients (n = 105) will be randomly assigned 1:1 to personalized or non-personalized treatment based on a cluster assignment of the West Haven-Yale Multidimensional Pain Inventory (MPI). In the personalized assignment condition, patients with high levels of distress receive an emotional distress-tailored intervention, patients with pain-related interference receive an exposure/extinction-tailored treatment intervention and patients who adapt relatively well to the pain receive a low-level smartphone-based activity diary intervention. In the control arm, patients receive one of the two non-matching interventions. Effect sizes will be calculated for change in core pain outcome domains (pain intensity, physical and emotional functioning, stress experience, participant ratings of improvement and satisfaction) after intervention and at follow-up. Feasibility and safety outcomes will assess rates of recruitment, retention, adherence and adverse events. Additional data on neurobiological and psychological characteristics of the patients are collected to improve treatment allocation in future studies.

Conclusion
Although the call for personalized treatment approaches is widely discussed, randomized controlled trials are lacking. As the personalization of treatment approaches is challenging, both allocation and intervention need to be dynamically coordinated. This study will test the feasibility and safety of a novel study design in order to provide a methodological framework for future multicentre RCTs for personalized pain psychotherapy.

Trial registration
German Clinical Trials Register, DRKS00022792 (https://www.drks.de). Prospectively registered on 04/06/2021.
Vertebrobasilar dolichoectasia in patients with cerebrovascular ischemic stroke: does it have a role in cerebral microbleeds?
Authors: Osama Ahmed , Negm Mohamed , Mosallam Walid , Hegazy Mohamed , Elshamly Samer 
Published: December 2022

AbstractBackgroundVertebrobasilar dolichoectasia (VBD) may account for cerebral microbleeds (CMBs) in ischemic cerebrovascular stroke.ObjectivesTo examine whether VBD is associated with the involvement of CMBs in any region and, if so, whether it is associated with CMBs among ischemic stroke patients located in posterior circulation territory. For patients with VBD, we also studied ischemic stroke subtypes, and checked whether dolichoectasia was linked to vascular risk factors.MethodsTwo hundred ischemic stroke patients in whom detailed clinical data and brain MRI sequences were obtained, and stroke subtyping with TOAST classification (Trial of ORG 10172 in Acute Stroke Treatment) was performed.ResultsThe mean age of patients was (65.22 ± 12.88), male patients were more frequent (67.5%); dyslipidemia was the most frequent risk factor (55%). Cardio-embolic stroke subtype was the most frequent (37%) and (71.5%) of patients had no history of previous use of antithrombotic drugs. Ectasia was found in 28 (14%), dolichosis was found in 50 (25%) and vertebrobasilar dolichoectasia was found in 19 (9.5%) of patients. Cerebral microbleeds were detected in 114 (57%) patients. Mild degree CMBs was the most prevalent among patients 69 (61%) and were located predominantly in both anterior and posterior territories 41 (36%). CMBs were significantly more frequent in hypertensive and older patients.ConclusionsIn patients with VBD, severe degree CMBs were more common and were located as a vascular territory supplied by vessels originating from dolichoectatic parent vessels in the posterior region.
Evaluation of the determinants of cognitive dysfunction in patients with multiple sclerosis
Authors: Javadi Alireza Haji Seyed , Shafikhani Ali Akbar , Beizapour Neda 
Published: December 2022

Abstract
Background
Cognitive dysfunction is common among patients with multiple sclerosis (MS); however, the determinants of cognitive dysfunction are still unknown. This study aimed to investigate the determinants of cognitive dysfunction in a relatively large sample of patients with MS for rapid screening.

Results
Fifty-three patients (33.6%) had cognitive dysfunction. According to the Wechsler Memory Scale, patients with relapsing-remitting MS (RRMS) and patients with progressive MS (PMS) had significantly lower scores than the control group. Patients with RRMS compared to the control group were 76.73 ± 8.50 versus 105.58 ± 8.71 (P < 0.01), and patients with PMS compared to the control group were 72.56 ± 6.44 versus 105.58 ± 8.71 (P < 0.01). In patients with RRMS, the factors affecting the emergence of cognitive dysfunction included disability, fatigue, depression, and duration of illness, whereas in patients with PMS, just the disability variable was related to the presence or absence of cognitive dysfunction.

Conclusions
Our findings showed that disability, fatigue, depression, and duration of illness were factors associated with cognitive dysfunction in patients with RRMS. Proper identification of these factors can be helpful in the screening of cognitive dysfunction in this population.
Sternberg’s canal: a rare site of CSF leak—our experience and management of a series of cases at a tertiary care hospital in South India
Authors: Chandrakiran C. , Jagannatha Aniruddha T. , Nori Sahiti , Reddy Harshavardhan N. 
Published: December 2022

Abstract
Background
The lateral craniopharyngeal canal or Sternberg’s canal is located in the postero-lateral part of the sphenoid sinus. It is the weakest area of the skull base, originating due to defective fusion during embryological development in a small proportion of individuals. Hence, it can give rise to CSF leaks from that region. Due to the proximity of this region to the internal carotid artery, optic nerve, and cavernous sinus, it proves to be challenging to repair these defects. The exact location, role in the causation of CSF leaks, and clinical presentation with arachnoid herniation are also subject to much controversy.

Results
In our case series, we describe 7 patients with the rare clinical entity of CSF leak from the Sternberg’s canal, who had a mean age of 38.4 years, 4 of whom also had an arachnoid herniation through the canal. One patient already underwent prior endoscopic surgery for the CSF leak. We highlight a trans-nasal trans-sphenoid approach with multi-layer closure, i.e., fat plug, fascia, and a naso-septal flap with the use of an additional layer of muscle in one of the cases, following which all had good outcomes. Since the primary concern with this rare clinical scenario is correct identification and adequate exposure of the leak for repair, we additionally undertook a trans-pterygoid approach in 2 of our patients.

Conclusions
The key to the successful repair of the Sternberg’s canal leak lies in its accurate identification and exposure. In our series, we achieved good exposure by drilling the pterygoids and lateral sphenoid walls along with the use of angled endoscopes for visualization. Our case series highlights the linear relation of elevated BMI with spontaneous CSF leaks in the absence of benign intracranial hypertension and the reinforcement of repair with the use of a harvested naso-septal flap. Our multi-layered closure ensured good results and no recurrence of a leak in any of our patients.
Prog-Plot – a visual method to determine functional relationships for false discovery rate regression methods
Authors: Bello Nicolás , López-Kleine Liliana 
Published: December 2022

ABSTRACT
Multiple test corrections are a fundamental step in the analysis of differentially expressed genes, as the number of tests performed would otherwise inflate the false discovery rate (FDR). Recent methods for P-value correction involve a regression model in order to include covariates that are informative of the power of the test. Here, we present Progressive proportions plot (Prog-Plot), a visual tool to identify the functional relationship between the covariate and the proportion of P-values consistent with the null hypothesis. The relationship between the proportion of P-values and the covariate to be included is needed, but there are no available tools to verify it. The approach presented here aims at having an objective way to specify regression models instead of relying on prior knowledge.
Does Using Indocyanine Green Fluorescence Imaging for Tumors Help in Determining the Safe Surgical Margin in Real-Time Navigation of Laparoscopic Hepatectomy? A Retrospective Study
Authors: Cai Xinran , Hong Haijie , Pan Wei , Chen Jiangzhi , Jiang Lei , Du Qiang , Li Ge , Lin Shengzhe , Chen Yanling 
Published: December 2022

Abstract
Background
This study aims to investigate whether indocyanine green (ICG) tumor imaging helps determine the safe surgical margin in laparoscopic hepatectomy.

Patients and Methods
Eighty-six patients with hepatic malignancies [including hepatocellular carcinoma (HCC) and colorectal liver metastasis (CRLM)] were included in this study. ICG-R15 testing was performed 5–7 days before surgery. Fluorescence staining of the tumor was detected by a fluorescent laparoscope, and the width of fluorescence band surrounding tumor was measured by an electronic vernier caliper.

Results
The positive rate of hepatic malignant lesions successfully stained by ICG fluorescence was 96.0% (95/99). HCC with better differentiation demonstrated non-rim fluorescence patterns, while cases with poor differentiation demonstrated rim patterns. CRLM uniformly demonstrated rim pattern. The width of fluorescence surrounding tumors was 0 in HCC with non-rim patterns. The minimum width of fluorescence surrounding tumors in poor differentiated HCC and CRLM were 2.4 ± 1.9 mm and 2.8 ± 2.5 mm, respectively, with no significant difference (P > 0.05). ICG fluorescence imaging revealed eight small lesions, which were not detected preoperatively in seven patients, of which five lesions were confirmed as malignancies by pathology.

Conclusions
Resection along the ICG fluorescence edge can supply a safe surgical margin only for CRLM, but not for HCC. Otherwise, ICG fluorescence tumor imaging can preliminarily determine the pathological type of hepatic malignancies and histological differentiation of HCC and help detect small lesions that cannot be detected preoperatively.
Predictive efficiency of phoenixin, spexin and kisspeptin neuropeptides concentration levels in diagnosis of bipolar disorder in paediatric population
Authors: Cichoń Lena , Janas-Kozik Małgorzata , Pałasz Artur , Wilczyński Krzysztof Maria , Suszka-Świtek Aleksandra , Żmijowska Anna , Jelonek Ireneusz 
Published: December 2022

Cel pracyCelem badania była ocena stężeń wybranych neuropeptydów : feniksyny, speksyny oraz kisspeptyny w surowicy krwi żylnej dzieci i młodzieży z choroba afektywną dwubiegunową, a tym samym ich skuteczności predykcyjnej w tym zaburzeniu.MetodaMateriał i metoda. Badanie objęło 75 osób w wieku średnio 15,26 lat (95%CI: 14.86-15.67 ), z czego grupę badaną stanowiło 57 osób z diagnozą choroby afektywnej dwubiegunowej, a grupę kontrolną - 18 osób bez diagnozy psychiatrycznej i nieleczonych farmakologicznie.
Feniksynę, speksynę i kisspeptynę oznaczano w surowicy krwi z żyły obwodowej. Pomiary stężeń neuropeptydów wykonano metodą immunoenzymatyczną ELISA.WynikiŚrednie stężenie feniksyny w grupie badanej wynosiło 1,57 ng/ml (95%CI: 1,35-1,79), natomiast w grupie kontrolnej – 2,69 ng/ml (95%CI: 2,38-3; U Mann-Whitney test p-value<0,05). W przypadku speksyny wyniki te wynosiły odpowiednio: 639,65 pg/ml (95%CI: 558,86-720,44) w grupie badanej oraz 354,28 pg/ml (95%CI: 310,33-398,22; U Mann-Whitney test p-value<0,05) w grupie kontrolnej. Obserwowane różnice były istotne statystycznie. W zakresie poziomu kisspeptyny średnie stężenie w grupie badanej wynosiło 126,02 pg/ml (95%CI: 39,82-212,23; mediana: 59,85), zaś w grupie kontrolnej - 54,83 pg/ml (95%CI: 39,23-70,43; mediana: 51,3; U Mann-Whitney test p-value=0,29), a obserwowana różnica nie była istotna statystycznie.WnioskiWystępowanie objawów choroby afektywnej dwubiegunowej jest w istotny statystycznie sposób powiązane z obniżonym stężeniem PNX oraz w niewielkim stopniu z podwyższonym stężeniem speksyny w surowicy krwi chorych. Nie wykazuje natomiast związku ze stężeniem kisspeptyny.
Household food insecurity risk indices for English neighbourhoods: Measures to support local policy decisions
Authors: Smith Dianna M. , Rixson Lauren , Grove Grace , Ziauddeen Nida , Vassilev Ivaylo , Taheem Ravita , Roderick Paul , Alwan Nisreen A. 
Published: December 2022

Background
In England, the responsibility to address food insecurity lies with local government, yet the prevalence of this social inequality is unknown in small subnational areas. In 2018 an index of small-area household food insecurity risk was developed and utilised by public and third sector organisations to target interventions; this measure needed updating to better support decisions in different settings, such as urban and rural areas where pressures on food security differ.

Methods
We held interviews with stakeholders (n = 14) and completed a scoping review to identify appropriate variables to create an updated risk measure. We then sourced a range of open access secondary data to develop an indices of food insecurity risk in English neighbourhoods. Following a process of data transformation and normalisation, we tested combinations of variables and identified the most appropriate data to reflect household food insecurity risk in urban and rural areas.

Results
Eight variables, reflecting both household circumstances and local service availability, were separated into two domains with equal weighting for a new index, the Complex Index, and a subset of these to make up the Simple Index. Within the Complex Index, the Compositional Domain includes population characteristics while the Structural Domain reflects small area access to resources such as grocery stores. The Compositional Domain correlated well with free school meal eligibility (rs = 0.705) and prevalence of childhood obesity (rs = 0.641). This domain was the preferred measure for use in most areas when shared with stakeholders, and when assessed alongside other configurations of the variables. Areas of highest risk were most often located in the North of England.

Conclusion
We recommend the use of the Compositional Domain for all areas, with inclusion of the Structural Domain in rural areas where locational disadvantage makes it more difficult to access resources. These measures can aid local policy makers and planners when allocating resources and interventions to support households who may experience food insecurity.
Impact of the COVID-19 Vaccination Program on case incidence, emergency department visits, and hospital admissions among children aged 5–17 Years during the Delta and Omicron Periods—United States, December 2020 to April 2022
Authors: Topf Katherine G. , Sheppard Michael , Marx Grace E. , Wiegand Ryan E. , Link-Gelles Ruth , Binder Alison M. , Cool Andrea J. , Lyons B. Casey , Park Sohyun , Fast Hannah E. , Presnetsov Arthur , Azondekon G. Roseric , Soetebier Karl A. , Adjemian Jennifer , Barbour Kamil E. 
Published: December 2022

Background
In the United States, national ecological studies suggest a positive impact of COVID-19 vaccination coverage on outcomes in adults. However, the national impact of the vaccination program on COVID-19 in children remains unknown. To determine the association of COVID-19 vaccination with U.S. case incidence, emergency department visits, and hospital admissions for pediatric populations during the Delta and Omicron periods.

Methods
We conducted an ecological analysis among children aged 5–17 and compared incidence rate ratios (RRs) of COVID-19 cases, emergency department visits, and hospital admissions by pediatric vaccine coverage, with jurisdictions in the highest vaccine coverage quartile as the reference.

Results
RRs comparing states with lowest pediatric vaccination coverage to the highest pediatric vaccination coverage were 2.00 and 0.64 for cases, 2.96 and 1.11 for emergency department visits, and 2.76 and 1.01 for hospital admissions among all children during the Delta and Omicron periods, respectively. During the 3-week peak period of the Omicron wave, only children aged 12–15 and 16–17 years in the states with the lowest versus highest coverage, had a significantly higher rate of emergency department visits (RR = 1.39 and RR = 1.34, respectively).

Conclusions
COVID-19 vaccines were associated with lower case incidence, emergency department visits and hospital admissions among children during the Delta period but the association was weaker during the Omicron period. Pediatric COVID-19 vaccination should be promoted as part of a program to decrease COVID-19 impact among children; however, vaccine effectiveness may be limited when available vaccines do not match circulating viral variants.