bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypothyroidism in type 2 diabetic patients: a tertiary care hospital experience
Authors: Qureshi Nazmul Kabir , Aktaruzzaman AHM , Amin Md Ruhul , Nahid Khan Lamia , Pathan Md Faruque 
Published: July 2022

Background Hypothyroidism is one of the most common endocrine disorders encountered in endocrine practice worldwide which is more prevalent in elderly and women and its prevalence varies according to population studied. Both type 1 and type 2 Diabetic patients have higher prevalence of hypothyroidism than normal population not for direct etiology rather due to autoimmune association and increasing age. Co-existing hypothyroidism may impose co-morbid effects of dyslipidemia, atherosclerosis, hypertension and renal impairment on diabetic patients.
Objective This study was designed to find out frequency and association of clinical and sub-clinical hypothyroidism in adult type 2 diabetic subjects.
Method This was a cross sectional study conducted during the period of December 2009 to November 2010 in a tertiary care specialized hospital, (BIRDEM). Thyroid hormone (FT4 and TSH) was studied among 227 adult type 2 diabetic subjects.
Results Among 227 study subjects, female respondents were 67%. Age (in years) was as mean± SD (SE) and (95% CI): 53.95±11.6 (.77) and (52.44-55.47). Thyroid hormone (FT4 and TSH) was assayed. FT4 (in pmol/L) of this population was as mean± SD (SE) and (95% CI): 13.05±2.66 (.18) and (12.71-13.4) and TSH was (in μIU/ml) as mean± SD(SE) and (95% CI): 4.12±7.03(.47) and (3.2-5.04). Sixty nine (30.4%) of them were hypothyroid and rest 158 (69.6%) were euthyroid. Among the hypothyroid cases, 17.6% were cases of sub-clinical hypothyroidism and 12.8% were of clinical hypothyroidism.
Conclusion Diabetic population have higher prevalence of hypothyroidism. While planning therapeutic approaches for diabetic patients, clinical and sub clinical hypothyroidism always should be taken into consideration. Diabetic patients with or without complication particularly with poor glycemic control, should be routinely screened for hypothyroidism.
JBSA 2012; 25(1): 14-20
Pandemia da Covid-19: A linha tênue entre a saúde mental e o processo de saúde-doença no graduando de enfermagem
Authors: Santos Larissa Christiny Amorim dos , Martinho Matheus Nery , Ribeiro Wanderson Alves , Souza Érica Motta Moreira de , Miranda Karollaine Barbosa Fontes , Silva Ewelyn Ribeiro de Lima 
Published: July 2022

O isolamento social devido a pandemia da COVID-19 é considerado um dos fatores de maior impacto na saúde mental do brasileiro, especialmente, na saúde dos acadêmicos. Estes impactos podem estar relacionados aos vários eventos de ansiedade e depressão desenvolvidos por estes estudantes durante o seu período de distanciamento social. O presente estudo se trata de uma revisão integrativa, definida como aquela que condensa pesquisas anteriores, trazendo conclusões globais de um corpo de literatura específica, o que permite a construção de análise ampla e contribui para discussões sobre métodos e resultados de pesquisa. Para tal foi realizada uma análise crítica dos artigos selecionados, expondo por meio de tabela os resultados encontrados, caracterizando, assim, uma abordagem qualitativa. Em seguida, os resultados foram discutidos a partir da comparação dos principais achados entre os autores, confrontando as diferentes evidências sobre a saúde mental do graduando de enfermagem durante a pandemia da COVID-19. Conclui-se que o maior impacto para os estudantes do ensino tradicional de enfermagem foram as aulas remotas, visto que algumas disciplinas preocupavam os estudantes quanto as aulas práticas, sendo a enfermagem uma ciência que trabalha com a vivência do ambiente, práticas motoras, e contato visual. Por isso, se torna necessário as consultas com psicólogos e psiquiatras gratuitos em programas de atendimento online, podendo este projeto, ser fomentado pelo poder público ou até mesmo pela instituição de ensino superior ao qual o acadêmico encontra-se matriculado para assim, ser possível amenizar os sentimentos que são sentidos pelos graduandos de enfermagem nesse período pandêmico.
Análise do perfil dos Grupos de Pesquisa sobre Gestão em Enfermagem no Brasil
Authors: Carvalho Rozana Neves Guimarães de , Silvino Zenith Rosa , Souza Claudio José de 
Published: July 2022

Objetivo: O presente estudo tem como objetivo analisar o perfil dos Grupos de Pesquisa sobre Gestão em Enfermagem no Brasil cadastrados no Diretório do Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Isto posto, busca-se fornecer dados concretos sobre a distribuição, ano de criação e as instituições nas quais se vinculam. Metodologia: Trata-se de um estudo descritivo-analítico, de abordagem quantitativa com utilização da cientometria. A pesquisa foi realizada em três etapas. A primeira etapa consistiu na busca parametrizada, na base corrente, com o termo de busca “Gerência em Enfermagem”, a segunda etapa relacionada à seleção de cada grupo dentro da linha de gestão com status certificado e a terceira etapa o agrupamento dos dados coletados em uma planilha do excel para viabilizar o mapeamento. Resultados e Discussão: Foram encontrados 71 Grupos de Pesquisas cadastrados no Diretório do CNPq, a partir do último censo dos grupos. Posteriormente, realizou-se o processo de garimpagem, e após excluir os grupos em situação de preenchimento (4 grupos), excluídos (11 grupos), não atualizados (13 grupos) e os não enquadrados na temática vigente (5 grupos), restaram 38 grupos de pesquisas na área de gestão em enfermagem. Um impeditivo enfrentado durante a coleta de dados residiu na instabilidade da plataforma. Conclusão: O levantamento quantitativo totalizou 38 grupos de pesquisa na linha da gestão, estes, dispostos em instituições de ensino superior de caráter público. Apontou para uma concentração de 42,11% no estado de SP, estando a USP detentora de 23,68%. Adicionalmente, identificou a criação de cinco novos grupos durante o contexto pandêmico e desvelou a necessidade de estímulos à implementação desses espaços dentro das universidades privadas, faculdades isoladas, centros de educação tecnológica e centros federais de educação tecnológica. Considera-se fundamental lutar por esses locais de inserção acadêmica, pela ampliação, pela preservação e valorização para uma educação mais crítica e engajada com a atualidade.
SKALA NYERI INSERSI INLET AV FISTULA PADA PASIEN HEMODIALISIS YANG DIBERIKAN KOMPRES DINGIN
Authors: ROJI FAHRUR 
Published: July 2022

ABSTRAK
Hemodialisis pada pasien gagal ginjal stadium akhir, dilakukan sebanyak dua sampai tiga kali dalam seminggu dengan lama tindakan antara 4-5 jam. setiap pasien dilakukan insersi fistula sebanyak dua sampai tiga kali dalam seminggu dan prosedur ini menimbulkan rasa nyeri. Tujuan penelitian untuk mengetahui perbedaan skala nyeri insersi inlet av fistula antara pasien yang diberikan kompres dingin dan tidak diberikan kompres dingin pada pasien hemodialisis di RSSA Malang. Desain yang digunakan dalam penelitian ini adalah metode penelitian quasy eksperimen dengan pendekatan Pretest-Posttest with control group. Teknik sampling yang digunakan adalah dengan purposive sampling. Jumlah sampel sebanyak 9 orang pada masing-masing kelompok. Hasil penelitian menunjukkan terdapat perbedaan skor skala nyeri insersi akses vaskuler antara sebelum (pre) dan sesudah (post) kompres dingin (p=0.007). Pada kelompok intervensi (kompres dingin) mampu menurunkan skala nyeri dibandingkan kelompok kontrol (p=0.000). Kompres dingin yang diaplikasikan sebelum pasien dilakukan prosedur insersi AVF mampu memberikan sensasi kebas pada lapisan kulit sehingga skala nyeri yang timbul dari prosedur hemodialisis menurun Diharapkan baik keluarga maupun perawat juga dapat memberikan terapi kompres dingin untuk mengurangi persepsi nyeri yang di rasakan pasien.

Kata Kunci: Hemodialisis, Nyeri, Kompres Dingin
No accelerated arterial aging in relatively young women after preeclampsia as compared to normotensive pregnancy
Authors: Janssen Emma B. N. J. , Hooijschuur Mieke C. E. , Lopes van Balen Veronica A. , Morina-Shijaku Erjona , Spaan Julia. J. , Mulder Eva G. , Hoeks Arnold P. , Reesink Koen D. , van Kuijk Sander M. J. , van't Hof Arnoud , van Bussel Bas C. T. , Spaanderman Marc E. A. , Ghossein-Doha Chahinda 
Published: July 2022

IntroductionPreeclampsia, an endothelial disorder of pregnancy, predisposes to remote cardiovascular diseases (CVD). Whether there is an accelerated effect of aging on endothelial decline in former preeclamptic women is unknown. We investigated if the arterial aging regarding endothelial-dependent and -independent vascular function is more pronounced in women with a history of preeclampsia as compared to women with a history of solely normotensive gestation(s).MethodsData was used from the Queen of Hearts study (ClinicalTrials.gov Identifier NCT02347540); a large cross-sectional study on early detection of cardiovascular disease among young women (≥18 years) with a history of preeclampsia and a control group of low-risk healthy women with a history of uncomplicated pregnancies. Brachial artery flow-mediated dilation (FMD; absolute, relative and allometric) and sublingually administered nitroglycerine-mediated dilation (NGMD; absolute and relative) were measured using ultrasound. Cross-sectional associations of age with FMD and NGMD were investigated by linear regression. Models were adjusted for body mass index, smoking, antihypertensive drug use, mean arterial pressure, fasting glucose, menopausal state, family history of CVD and stress stimulus during measurement. Effect modification by preeclampsia was investigated by including an interaction term between preeclampsia and age in regression models.ResultsOf the 1,217 included women (age range 22–62 years), 66.0% had a history of preeclampsia and 34.0% of normotensive pregnancy. Advancing age was associated with a decrease in relative FMD and NGMD (unadjusted regression coefficient: FMD: −0.48%/10 years (95% CI:−0.65 to −0.30%/10 years), NGMD: −1.13%/10 years (−1.49 to −0.77%/10 years)) and increase in brachial artery diameter [regression coefficient = 0.16 mm/10 years (95% CI 0.13 to 0.19 mm/10 years)]. Similar results were found when evaluating FMD and NGMD as absolute increase or allometrically, and after confounder adjustments. These age-related change were comparable in former preeclamptic women and controls (p-values interaction ≥0.372). Preeclampsia itself was independently associated with consistently smaller brachial artery diameter, but not with FMD and NGMD.ConclusionIn young- to middle-aged women, vascular aging in terms of FMD and NGMD was not accelerated in women after preeclampsia compared to normotensive pregnancies, even though former preeclamptic women consistently have smaller brachial arteries.
Graft preservation confers myocardial protection during coronary artery bypass grafting
Authors: Szalkiewicz Philipp , Emmert Maximilian Y. , Heinisch Paul P. , Arnold Zsuzsanna , Crailsheim Ingo , Mach Markus , Aschacher Thomas , Grabenwöger Martin , Winkler Bernhard 
Published: July 2022

BackgroundDuring on-pump coronary artery bypass grafting (ONCAB), graft flushing for distal anastomoses testing also perfuses the downstream myocardium. This single-center retrospective study evaluated the impact of specific preservation solutions on myocardial protection during ONCAB.Materials and methodsBetween July 2019 and March 2020 either DuraGraft (DG) or 0.9% Saline/Biseko (SB) was applied to 272 ONCAB. Overall, 166 patients were propensity-matched into two groups. Cardiac enzymes [high-sensitive Troponin I (hs-TnI) and creatine kinase (CK)] were evaluated 7 days post-surgery.ResultsPost-surgery, hs-TnI values were significantly lower from 3 to 6 h (h) up to 4 days in the DG group: 3–6 h: 4,034 ng/L [IQR 1,853–8,654] vs. 5,532 ng/L [IQR 3,633—8,862], p = 0.05; 12–24 h: 2,420 ng/L [IQR 1,408–5,782] vs. 4,166 [IQR 2,052–8,624], p &lt; 0.01; 2 days: 1,095 ng/L [IQR 479–2,311] vs. 1,564 ng/L [IQR 659–5,057], p = 0.02 and at 4 days: 488 ng/L [IQR 232–1,061] vs. 745 ng/L [IQR 319–1,820], p = 0.03. The maximum value: 4,151 ng/L [IQR 2,056–8,621] vs. 6,349 ng/L [IQR 4,061–12,664], p &lt; 0.01 and the median area under the curve (AUC): 6,146 ng/L/24 h [IQR 3,121–13,248] vs. 10,735 ng/L/24 h [IQR 4,859–21,484], p = 0.02 were lower in the DG group. CK values were not significantly different between groups: maximum value 690 [IQR 417–947] vs. 631 [464–979], p = 0.61 and AUC 1,986 [1,226–2,899] vs. 2,081 [1,311–3,063], p = 0.37.ConclusionRepeated graft flushing with DG resulted in lower Troponin values post-surgery suggesting enhanced myocardial protection compared to SB. Additional studies are warranted to further assess the myocardial protection properties of DG.
Epidemiology of atrial fibrillation and risk of CVD mortality among hypertensive population: A prospective cohort study in Northeast China
Authors: Du Zhi , Lin Min , Tian Yuanmeng , Jing Li , Liu Shuang , Li Guangxiao , Jia Tong , Sun Qun , Shi Lei , Sun Jixu , Tian Wen , Xing Liying 
Published: July 2022

BackgroundDetermining risk factors of cardiovascular disease (CVD)-related mortality and evaluating their influence are important for effectively reducing corresponding mortality. However, few research findings have estimated the relationship between atrial fibrillation (AF) and CVD-related mortality among hypertension individuals.ObjectiveThe objective of this study was to investigate the epidemiology of AF in a hypertension population and determine the relationship between AF and CVD-related mortality.MethodsUsing a multistage, stratified, and cluster random sampling method, the prospective cohort study with a median follow-up of 3.51 years enrolled 10,678 hypertensive participants at baseline. The prevalence, awareness, and anticoagulation data of AF in this focal population were carefully assessed. Stepwise logistic regression and Cox regression analysis were respectively performed to evaluate the determinants of AF and the association between AF and CVD-related mortality.ResultsThe overall prevalence of AF was 1.3% (95% CI, 1.1%−1.6%) in the hypertensive population, and it was higher in men than in women (1.8% vs. 1.0%, respectively; p=0.001). The awareness of AF was 53.1%, and the rate of oral anticoagulant (OAC) therapy was only 4.2%, although all AF participants should have required according to the European Society of Cardiology guidelines. The determinants of AF included elder, male, and history of coronary heart disease in the hypertensive population. Besides, compared with individuals without AF, the risk of CVD-related mortality significantly increased in the hypertensive population with AF (HR 3.37, 95% CI 2.10–5.40).ConclusionOur results indicated a huge burden of AF and underuse of OAC therapy for them in a community-based hypertensive population. Considering that most of the risk factors of AF were unmodifiable in hypertensive individuals, as well as its high risk of mortality, long-term interventions including AF education, timely screening, and widespread use of OACs should be emphasized in the focal populations.
Case Report: Artifactual Hypoglycemia: A Condition That Should Not Be Forgotten
Authors: Amaral Sara , Palha Ana , Bernardino Vera , Silva-Nunes José 
Published: July 2022

BackgroundHypoglycemia is uncommon in people who are not being treated for diabetes mellitus and, when present, the differential diagnosis is broad. Artifactual hypoglycemia describes discrepancy between low capillary and normal plasma glucose levels regardless of symptoms and should be considered in patients with Raynaud’s phenomenon.Case PresentationA 46-year-old female patient with a history of a sleeve gastrectomy started complaining about episodes of lipothymias preceded by sweating, nausea, and dizziness. During one of these episodes, a capillary blood glucose was obtained with a value of 24 mg/dl. She had multiple emergency admissions with low-capillary glycemia. An exhaustive investigation for possible causes of hypoglycemia was made for 18 months. The 72h fasting test was negative for hypoglycemia. A Raynaud’s phenomenon was identified during one appointment.ConclusionArtifactual hypoglycemia has been described in various conditions including Raynaud’s phenomenon, peripheral arterial disease, Eisenmenger syndrome, acrocyanosis, or hypothermia. With this case report, we want to reinforce the importance of being aware of this diagnosis to prevent anxiety, unnecessary treatment, and diagnostic tests.
Modified acupuncture therapy, long-term acupoint stimulation versus sham control for weight control: a multicenter, randomized controlled trial
Authors: Dai Liang , Wang Miao , Zhang Ke-Pei , Wang Lin , Zheng Hui-Min , Li Chun-Bo , Zhou Wen-Jun , Zhou Shi-Gao , Ji Guang 
Published: July 2022

ObjectiveLong-term acupoint stimulation (LAS), also called embedding acupuncture, is a modified acupuncture technique. The preliminary results have demonstrated its efficacy in body-weight control. However, the low quality of available trials limited its application. This study aimed to evaluate the efficacy and safety of LAS in body-weight control by using a randomized, parallel, sham-controlled clinical trial design.MethodsThis was a randomized, single-blind, sham-controlled clinical trial including 84 adult participants (18–60 years) with a body mass index (BMI) of ≥ 24 kg/m2 conducted in three general hospitals in Shanghai, China. Participants were equally assigned to receive LAS or sham LAS (SLAS) once per 10 days, eight times in total. After completion, an additional intervention with a 3-month follow-up period was set to examine the continued effect of LAS. The primary outcome was the change in body weight from baseline to treatment endpoint within the intention-to-treat (ITT) analysis. Secondary outcomes contained changes in waist-to-hip ratio (WHR), lipid metabolism, and visceral and subcutaneous adipose tissues.ResultsFrom 14 May 2018 to 03 November 2019, 84 participants out of 201 screened individuals met the eligibility criteria, were randomized, and were analyzed (42 participants in each group). From baseline to treatment endpoint, the body-weight reduction in the LAS group was significantly larger than in the sham control (net difference: 1.57 kg, 95% CI: 0.29–2.86, p = 0.012). The superior weight reduction effect persisted in the follow-up period (net difference: 3.20 kg, 95% CI: 1.17–5.21, p = 0.001). LAS therapy also showed improvement in triglyceride and subcutaneous adipose tissue (SAT) compared with sham control. One participant in the LAS group reported a slightly uncomfortable and tingling sensation after the additional intervention. No other adverse events (AEs) were documented.ConclusionLAS, a modified acupuncture technique, is safe and effective in body-weight control. It could be used as an alternative choice to classical acupuncture for obesity management.Clinical Trial Registration[www.chictr.org.cn], identifier [ChiCTR1800015498].
Fear of hypoglycemia and quality of life in young people with type 1 diabetes and their parents in the era of sensor glucose monitoring
Authors: Glocker Vivien , Bachmann Sara , Hess Melanie , Szinnai Gabor , Burckhardt Marie-Anne 
Published: July 2022

IntroductionIt is crucial to understand psychosocial outcomes in children and adolescents with type 1 diabetes (T1D) and their families to provide optimal family-centered care. Hence, the aim of this study was to explore psychosocial outcomes in young people with T1D and their parents using currently available glucose monitoring devices in a real-life clinic setting.MethodsChildren and adolescents aged 2-18 years with T1D for more than 6 months and their parents were recruited into a cross-sectional study to complete the Hypoglycemia Fear Survey (HFS) and the Pediatric Quality of Life Inventory (PedsQL) Generic Score Scales, Diabetes Module and Family Impact Module. Demographics and diabetes-specific parameters were obtained from medicals records.ResultsFifty-nine children and adolescents (mean age 15.1 ± 3.0 years) and 49 parents of children (mean age of children 12.5± 3.3 years) of which 44 were child-parent dyads completed the questionnaires. Parents had a higher mean (SD) FOH total and worry subscore than children, total score was 37.9 (14.6) vs. 32.2 (11.9), p = 0.047 and worry subscore was 17.8 (10.4) vs. 12.8 (9.0), p = 0.01. Furthermore, lower parental diabetes-specific QoL score was observed in parents, 78.8 (12.2) vs. 82.7 (10.3), p=0.02. No difference in FOH and QoL between real-time continuous glucose monitoring (rtCGM) and intermittently scanned glucose monitoring (isCGM) users and users of devices with and without alerts was observed. In isCGM users (n=36 completing the child questionnaires, n=33 completing parent questionnaires), higher parental FOH and lower parental diabetes-specific QoL correlated with higher scanning frequency, r = 0.399, p = 0.021, and r = -0.464, p = 0.007 respectively. No significant correlation was documented between scanning frequency and child questionnaire scores.ConclusionsParents are more likely to perceive higher levels of psychosocial burden related to their child’s diabetes than children and adolescents with T1D, especially parents of younger children. This highlights the need for family-based education and treatment resources to support parents in diabetes management in addition to rapidly advancing diabetes technology. In isCGM users, higher parental FOH and lower parent-perceived QoL correlated with a higher scanning frequency, indicating the potential impact of glucose monitoring modality on psychosocial outcomes or vice versa.