bluuebunny/crossref_metadata_2025_split huggingface dataset:
Albedo changes caused by future urbanization contribute to global warming
Authors: Ouyang Zutao , Sciusco Pietro , Jiao Tong , Feron Sarah , Lei Cheyenne , Li Fei , John Ranjeet , Fan Peilei , Li Xia , Williams Christopher A. , Chen Guangzhao , Wang Chenghao , Chen Jiquan 
Published: July 2022

AbstractThe replacement of natural lands with urban structures has multiple environmental consequences, yet little is known about the magnitude and extent of albedo-induced warming contributions from urbanization at the global scale in the past and future. Here, we apply an empirical approach to quantify the climate effects of past urbanization and future urbanization projected under different shared socioeconomic pathways (SSPs). We find an albedo-induced warming effect of urbanization for both the past and the projected futures under three illustrative scenarios. The albedo decease from urbanization in 2018 relative to 2001 has yielded a 100-year average annual global warming of 0.00014 [0.00008, 0.00021] °C. Without proper mitigation, future urbanization in 2050 relative to 2018 and that in 2100 relative to 2018 under the intermediate emission scenario (SSP2-4.5) would yield a 100-year average warming effect of 0.00107 [0.00057,0.00179] °C and 0.00152 [0.00078,0.00259] °C, respectively, through altering the Earth’s albedo.
Photochemical Synthesis of Transition Metal-Stabilized Uranium(VI) Nitride Complexes
Authors: Xin Xiaoqing , Douair Iskander , Rajeshkumar Thayalan , Zhao Yue , Wang Shuao , Maron Laurent , Zhu Congqing 
Published: July 2022

AbstractUranium nitrides play important roles in dinitrogen activation and functionalization and in chemistry for nuclear fuels, but the synthesis and isolation of the highly reactive uranium(VI) nitrides remains challenging. Here, we report an example of transition metal (TM) stabilized U(VI) nitride complexes, which are generated by the photolysis of azide-bridged U(IV)-TM (TM = Rh, Ir) precursors. The U(V) nitride intermediates with bridged azide ligands are isolated successfully by careful control of the irradiation time, suggesting that the photolysis of azide-bridged U(IV)-TM precursors is a stepwise process. The presence of two U(VI) nitrides stabilized by three TMs is clearly demonstrated by an X-ray crystallographic study. These TM stabilized U(V) nitride intermediates and U(VI) nitride products exhibit excellent stability both in the solid-state and in THF solution under ambient light. Density functional theory calculations show that the photolysis necessary to break the N-N bond of the azide ligands implies excitation from uranium f-orbital to the lowest unoccupied molecular orbital (LUMO), as suggested by the strong antibonding N-(N2) character present in the latter.
Interactions of boron nitride nanosheet with amino acids of differential polarity
Authors: Najafi Fatemeh , Farzad Farzaneh , Pasban Samaneh 
Published: July 2022

AbstractFree amino acids represent a category of different biomolecules in the blood plasma, which bond together to make up larger organic molecules such as peptides and proteins. Their interactions with biocompatible nanoparticles are especially important for plasma-related biomedical applications. Among the various nanomaterials, the applications of carbon and boron nitride-based nanotubes/nanosheets have shown a huge increase in recent years. The effect of molecular polarity on the interaction between a boron nitride nanosheet (BNNS) and amino acids is investigated with quantum mechanical calculations by density functional theory (DFT), classical MD simulations, and well-tempered metadynamics simulations. Four representative amino acids, namely, alanine (Ala), a nonpolar amino acid, and aspartic acid (Asp), lysine (Lys) and serine (Ser), three polar amino acids are considered for their interactions with BNNS. In DFT calculations, the values of the adsorption energies for Lys-BNNS and Ser-BNNS complexes are − 48.32 and − 32.89 kJ/mol, respectively, which are more stable than the other cases. Besides, the adsorption energy calculated confirms the exergonic reactions for all investigated systems; it implied that the interaction is favorable electronically. The MD results show that the LYS molecules have a higher attraction toward BNNS because of its alkane tail in its side chain, and the ASP revealed the repulsion force originating from its COO– group. All the results are confirmed by free energy analyzes in which the LYS showed the highest adsorption free energy at a relatively farther distance than other complexes. In fact, our results revealed the contribution of functional groups and backbone of the amino acids in the adsorption or repulsion features of the studied systems.
Plutonium isotopes in the North Western Pacific sediments coupled with radiocarbon in corals recording precise timing of the Anthropocene
Authors: Yokoyama Yusuke , Tims Stephen , Froehlich Michaela , Hirabayashi Shoko , Aze Takahiro , Fifield L. Keith , Koll Dominik , Miyairi Yosuke , Pavetich Stefan , Kuwae Michinobu 
Published: July 2022

AbstractPlutonium (Pu) has been used as a mid-twentieth century time-marker in various geological archives as a result of atmospheric nuclear tests mainly conducted in 1950s. Advancement of analytical techniques allows us to measure 239Pu and 240Pu more accurately and can thereby reconstruct the Pacific Pu signal that originated from the former Pacific Proving Grounds (PPG) in the Marshall Islands. Here, we propose a novel method that couples annual banded reef building corals and nearshore anoxic marine sediments to provide a marker to precisely determine the start of the nuclear era which is known as a part of the Anthropocene. We demonstrate the efficacy of the methods using sediment obtained from Beppu Bay, Japan, and a coral from Ishigaki Island, Japan. The sedimentary records show a clear Pu increase from 1950, peaking during the 1960s, and then showing a sharp decline during the 1970s. However, a constantly higher isotope ratio between 239Pu and 240Pu suggest an additional contribution other than global fallout via ocean currents. Furthermore, single elevations in 240Pu/239Pu provide supportive evidence of close-in-fallout similar to previous studies. Coral skeletal radiocarbon displays a clear timing with the signatures supporting the reliability of the Beppu Bay sediments as archives and demonstrates the strength of this method to capture potential Anthropocene signatures.
An artificial intelligence algorithm is highly accurate for detecting endoscopic features of eosinophilic esophagitis
Authors: Römmele Christoph , Mendel Robert , Barrett Caroline , Kiesl Hans , Rauber David , Rückert Tobias , Kraus Lisa , Heinkele Jakob , Dhillon Christine , Grosser Bianca , Prinz Friederike , Wanzl Julia , Fleischmann Carola , Nagl Sandra , Schnoy Elisabeth , Schlottmann Jakob , Dellon Evan S. , Messmann Helmut , Palm Christoph , Ebigbo Alanna 
Published: July 2022

AbstractThe endoscopic features associated with eosinophilic esophagitis (EoE) may be missed during routine endoscopy. We aimed to develop and evaluate an Artificial Intelligence (AI) algorithm for detecting and quantifying the endoscopic features of EoE in white light images, supplemented by the EoE Endoscopic Reference Score (EREFS). An AI algorithm (AI-EoE) was constructed and trained to differentiate between EoE and normal esophagus using endoscopic white light images extracted from the database of the University Hospital Augsburg. In addition to binary classification, a second algorithm was trained with specific auxiliary branches for each EREFS feature (AI-EoE-EREFS). The AI algorithms were evaluated on an external data set from the University of North Carolina, Chapel Hill (UNC), and compared with the performance of human endoscopists with varying levels of experience. The overall sensitivity, specificity, and accuracy of AI-EoE were 0.93 for all measures, while the AUC was 0.986. With additional auxiliary branches for the EREFS categories, the AI algorithm (AI-EoE-EREFS) performance improved to 0.96, 0.94, 0.95, and 0.992 for sensitivity, specificity, accuracy, and AUC, respectively. AI-EoE and AI-EoE-EREFS performed significantly better than endoscopy beginners and senior fellows on the same set of images. An AI algorithm can be trained to detect and quantify endoscopic features of EoE with excellent performance scores. The addition of the EREFS criteria improved the performance of the AI algorithm, which performed significantly better than endoscopists with a lower or medium experience level.
Comparative adsorptive behaviour of cow dung ash and starch as potential eco-friendly matrices for controlled organophosphorus pesticides delivery
Authors: Okafor Chinyere Emmanuella , Onyido Ikenna 
Published: July 2022

AbstractThe work reported herein explores the viability of cow dung ash (CDA) as a matrix for controlled pesticide delivery, by comparing its adsorptive characteristics towards two organophosphorus pesticides with those of starch, conventionally utilized in designing controlled pesticide delivery systems. CDA was characterized by Fourier transform infrared (FTIR) spectroscopy and powder X-ray diffraction (PXRD). Data for pesticide adsorption on the surfaces correlate well with Langmuir and Freundlich isotherms, with the former isotherm giving a slightly better fit (R2 ≥ 0.90) than the latter (R2 ≥ 0.81). Values of the adsorption parametersKLandRLindicate favourable pesticide adsorption on both surfaces. Desorption is the microscopic reverse of adsorption; both processes obey pseudo-second-order kinetics. The implication of this kinetic form is a mechanism in which adsorbate diffusion to the polymer surface and its transport into the polymer interior are important events. The isothermal and kinetic ratios,$$\frac{{K_{L}^{CDA} }}{{K_{L}^{Starch} }} = 3.8$$KLCDAKLStarch=3.8and 4.0,$$\frac{{k_{2}^{CDA} }}{{k_{2}^{Starch} }} = 1.3$$k2CDAk2Starch=1.3and 0.6, and$$\frac{{k_{ - 2}^{CDA} }}{{k_{ - 2}^{Starch} }} = 5.2$$k-2CDAk-2Starch=5.2and 1.0 at pH 7.0 and 27 °C, compare the adsorptive behaviour of diazinon and dichlorvos, respectively, on CDA and starch. These parameters are of the same order of magnitude, signalling that CDA is as potentially viable as starch for use as a matrix for pesticide-controlled delivery.
Targeting bladder function with network-specific epidural stimulation after chronic spinal cord injury
Authors: Herrity April N. , Aslan Sevda C. , Mesbah Samineh , Siu Ricardo , Kalvakuri Karthik , Ugiliweneza Beatrice , Mohamed Ahmad , Hubscher Charles H. , Harkema Susan J. 
Published: July 2022

AbstractProfound dysfunctional reorganization of spinal networks and extensive loss of functional continuity after spinal cord injury (SCI) has not precluded individuals from achieving coordinated voluntary activity and gaining multi-systemic autonomic control. Bladder function is enhanced by approaches, such as spinal cord epidural stimulation (scES) that modulates and strengthens spared circuitry, even in cases of clinically complete SCI. It is unknown whether scES parameters specifically configured for modulating the activity of the lower urinary tract (LUT) could improve both bladder storage and emptying. Functional bladder mapping studies, conducted during filling cystometry, identified specific scES parameters that improved bladder compliance, while maintaining stable blood pressure, and enabled the initiation of voiding in seven individuals with motor complete SCI. Using high-resolution magnetic resonance imaging and finite element modeling, specific neuroanatomical structures responsible for modulating bladder function were identified and plotted as heat maps. Data from this pilot clinical trial indicate that scES neuromodulation that targets bladder compliance reduces incidences of urinary incontinence and provides a means for mitigating autonomic dysreflexia associated with bladder distention. The ability to initiate voiding with targeted scES is a key step towards regaining volitional control of LUT function, advancing the application and adaptability of scES for autonomic function.
Differential regulation of mRNAs and lncRNAs related to lipid metabolism in Duolang and Small Tail Han sheep
Authors: Liu Tianyi , Feng Hui , Yousuf Salsabeel , Xie Lingli , Miao Xiangyang 
Published: July 2022

AbstractThe function of long non-coding RNA (lncRNA) can be achieved through the regulation of target genes, and the deposition of fat is regulated by lncRNA. Fat has an important effect on meat quality. However, there are relatively few studies on lncRNAs in the subcutaneous adipose tissue of Duolang sheep and Small Tail Han sheep. In this study, RNA-Seq technology and bioinformatics methods were used to identify and analyze the lncRNA and mRNA in the subcutaneous adipose tissue of the two breeds of sheep. The results showed that 107 lnRNAs and 1329 mRNAs were differentially expressed. The differentially expressed genes and lncRNA target genes were significantly enriched in the biosynthesis of unsaturated fatty acids signaling pathway, fatty acid metabolism, adipocyte differentiation and other processes related to fat deposition. Among them, LOC105616076, LOC114118103, LOC105607837, LOC101116622, and LOC105603235 target FADS1, SCD, ELOVL6, HSD17B12 and HACD2, respectively. They play a key regulatory role in the biosynthesis of unsaturated fatty acids. This study lays a foundation for the study of the molecular mechanism of lncRNA on fat development, and has reference value for studying the differences in fat deposition between Duolang sheep and Small Tail Han sheep.
Bexarotene-induced cell death in ovarian cancer cells through Caspase-4-gasdermin E mediated pyroptosis
Authors: Kobayashi Tatsuya , Mitsuhashi Akira , Hongying Piao , Shioya Masashi , Kojima Katsushi , Nishikimi Kyoko , Yahiro Kinnosuke , Shozu Makio 
Published: July 2022

AbstractBexarotene selectively activates retinoid X receptor, which is a commonly used anticancer agent for cutaneous T-cell lymphoma. In this study, we aimed to investigate the anticancer effect of bexarotene and its underlying mechanism in ovarian cancer in vitro. The ES2 and NIH:OVACAR3 ovarian cancer cell lines were treated with 0, 5, 10, or 20 µM of bexarotene. After 24 h, cell number measurement and lactate dehydrogenase (LDH) cytotoxicity assay were performed. The effect of bexarotene on CDKN1A expression, cell cycle-related protein, cell cycle, pyroptosis, and apoptosis was evaluated. Bexarotene reduced cell proliferation in all concentrations in both the cells. At concentrations of > 10 µM, extracellular LDH activity increased with cell rupture. Treatment using 10 µM of bexarotene increased CDKN1A mRNA levels, decreased cell cycle-related protein expression, and increased the sub-G1 cell population in both cells. In ES2 cells, caspase-4 and GSDME were activated, whereas caspase-3 was not, indicating that bexarotene-induced cell death might be pyroptosis. A clinical setting concentration of bexarotene induced cell death through caspase-4–mediated pyroptosis in ovarian cancer cell lines. Thus, bexarotene may serve as a novel therapeutic agent for ovarian cancer.
Sex differences in the winter activity of desert hedgehogs (Paraechinus aethiopicus) in a resource-rich habitat in Qatar
Authors: Pettett Carly E. , Salazar Rosie D. , Al-Hajri Afra , Al-Jabiri Hayat , Macdonald David W. , Yamaguchi Nobuyuki 
Published: July 2022

AbstractHedgehogs’ wide distribution and breadth of habitat use means they are a good model taxon for investigating behavioural responses to winter conditions, such as low temperatures and resource availability. We investigated the over-winter behaviour of desert hedgehogs (Paraechinus aethiopicus) in Qatar by radio-tracking 20 individuals and monitoring the body mass of 31 hedgehogs. Females spent more nights (38.63% of nights tracked) inactive than males (12.6%) and had lower monthly activity levels. The mean temperature on nights where hedgehogs were inactive was 14.9 °C compared with 17.0 °C when hedgehogs were active. By December, females lost a higher percentage of their November body mass than did males, but by February males had lost a higher percentage than females. We conclude that these sex differences in behaviour are a result of differing reproductive strategies with males becoming more active early in spring to search for mates, whereas female hedgehogs conserve energy for producing and raising young and avoid harassment by males. The winter activity of males may be facilitated by the resource-rich environment created by humans at this study site, and basking behaviour. This study highlights intraspecific and interspecific variation in behavioural strategies/tactics in response to winter conditions.
Familiarity modulates both intra- and interspecific yawn contagion in red-capped mangabeys
Authors: Pedruzzi Luca , Aychet Juliette , Le Vern Lise , Maglieri Veronica , Rossard Arnaud , Lemasson Alban , Palagi Elisabetta 
Published: July 2022

AbstractYawn contagion (YC) is, compared to spontaneous yawning, an evolutionary recent phenomenon probably linked to behavioral synchronization in highly social species that is more likely when it involves familiar subjects. Here, we investigate for the first time in monkeys which factors modulate intra- and interspecific YC. Through an experimental approach, we exposed 17 red-capped mangabeys to video stimuli (Yawn vs Control) depicting familiar/unfamiliar red-capped mangabeys and humans, and unfamiliar hamadryas. We found that mangabeys yawned more often in response to Yawn than Control videos independently from the species depicted, demonstrating both intra- and interspecific YC in the tested species. Moreover, both mangabey and human familiar yawning stimuli evoked a stronger yawning response in the subjects compared to the unfamiliar counterparts. Neither the amount of time spent looking frontally at the screen (probability of stimulus perception) nor the levels of self-directed behaviors (a proxy of anxiety) accounted for the results. In conclusion, we provide the first evidence that in non-human primate familiarity modulates both intra- and inter-specific YC. Stimuli emitted by familiar faces somehow ease the mechanisms underlying YC, and this modulation can also apply to heterospecific subjects when previous shared experiences provide the prerequisites for the development of social bonds.
Classification of antimicrobial mechanism of action using dynamic bacterial morphology imaging
Authors: Ouyang Xudong , Hoeksma Jelmer , Lubbers Ronnie J. M. , Siersma Tjalling K. , Hamoen Leendert W. , den Hertog Jeroen 
Published: July 2022

AbstractAntimicrobial resistance is a major threat to human health. Basic knowledge of antimicrobial mechanism of action (MoA) is imperative for patient care and for identification of novel antimicrobials. However, the process of antimicrobial MoA identification is relatively laborious. Here, we developed a simple, quantitative time-lapse fluorescence imaging method, Dynamic Bacterial Morphology Imaging (DBMI), to facilitate this process. It uses a membrane dye and a nucleoid dye to track the morphological changes of single Bacillus subtilis cells in response to antimicrobials for up to 60 min. DBMI of bacterial cells facilitated assignment of the MoAs of 14 distinct, known antimicrobial compounds to the five main classes. We conclude that DBMI is a simple method, which facilitates rapid classification of the MoA of antimicrobials in functionally distinct classes.
Clinical features and histopathological analysis of corneal myxoma
Authors: Al-Qahtani Bader S. , Alkatan Hind M. , Khandekar Rajiv , Al-Salem Ahmed , Al-Swailem Samar A. 
Published: July 2022

AbstractTo describe the presentation, histopathological characteristics, and management outcomes for corneal myxoma. This one-armed cohort study evaluated histologically confirmed consecutive cases of corneal myxoma. Data were evaluated on demographics, clinical presentation, management, histopathological and immunohistochemical features, and outcomes; visual acuity and corneal clarity. The study sample was comprised of 10 eyes (10 patients). The median age at presentation was 10.5 years. Five eyes had high intraocular pressure, four eyes had decreased distance visual acuity and one eye became discolored. Surgical management included penetrating keratoplasty (8 eyes), phototherapeutic keratectomy (1 eye), and evisceration because of a blind painful eye (1 eye). Postoperative best-corrected distance vision ranged from 20/20 to 20/60 (1 eye), < 20/60 to 20/200 (2 eyes), < 20/200 to 20/400 (1 eye), < 20/200 to light perception (4 eyes) and no light perception (1 eye). The histopathology of these lesions showed typical subepithelial proliferating spindle-shaped cells of mesenchymal origin within a myxoid stroma rich in glycosaminoglycan. The median duration of follow-up was 5 years. Recurrence was observed in an eye that underwent local excision. Corneal myxoma is a rare lesion that is presumably isolated, secondary, and reactive in nature. Surgically management yields reasonably favorable outcomes.
Bioavailable iron titrations reveal oceanic Synechococcus ecotypes optimized for different iron availabilities
Authors: Gilbert Naomi E , LeCleir Gary R , Strzepek Robert F , Ellwood Michael J , Twining Benjamin S , Roux S , Pennacchio C , Boyd Philip W , Wilhelm Steven W 
Published: July 2022

Abstract
The trace metal iron (Fe) controls the diversity and activity of phytoplankton across the surface oceans, a paradigm established through decades of in situ and mesocosm experimental studies. Despite widespread Fe-limitation within high-nutrient, low chlorophyll (HNLC) waters, significant contributions of the cyanobacterium Synechococcus to the phytoplankton stock can be found. Correlations among differing strains of Synechococcus across different Fe-regimes have suggested the existence of Fe-adapted ecotypes. However, experimental evidence of high- versus low-Fe adapted strains of Synechococcus is lacking, and so we investigated the transcriptional responses of microbial communities inhabiting the HNLC, sub-Antarctic region of the Southern Ocean during the Spring of 2018. Analysis of metatranscriptomes generated from on-deck incubation experiments reflecting a gradient of Fe-availabilities reveal transcriptomic signatures indicative of co-occurring Synechococcus ecotypes adapted to differing Fe-regimes. Functional analyses comparing low-Fe and high-Fe conditions point to various Fe-acquisition mechanisms that may allow persistence of low-Fe adapted Synechococcus under Fe-limitation. Comparison of in situ surface conditions to the Fe-titrations indicate ecological relevance of these mechanisms as well as persistence of both putative ecotypes within this region. This Fe-titration approach, combined with transcriptomics, highlights the short-term responses of the in situ phytoplankton community to Fe-availability that are often overlooked by examining genomic content or bulk physiological responses alone. These findings expand our knowledge about how phytoplankton in HNLC Southern Ocean waters adapt and respond to changing Fe supply.
Output feedback based poles configuration for LDP systems with varying state and input dimensions
Authors: Gao Jixun , Han Chaofei , Zhao Yuanyuan , Lv Lingling 
Published: July 2022

AbstractThe problem of pole configuration via periodic output feedback for linear discrete periodic systems with time‐varying dimensions of states and input spaces is addressed. By some mathematical derivation, the considered problem can be reduced into solving a special Sylvester matrix equation from which the periodic output feedback gains can be separated and computed explicitly. Based on this, a detail parametric algorithm is presented, by which countless periodic output feedback gains can be generated by choosing different free parameter matrices. Furthermore, the proposed approach is used to achieve robustness performance and robust poles configuration algorithm is provided. Numerical examples are employed to illustrate the effectiveness of the proposed algorithms.