bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organic Afterglow Emulsions Exhibiting 2.4 s Phosphorescence Lifetimes and Specific Protein Binding Property
Authors: Liu Jiahui , Sun Yan , Wang Guangming , Chen Xiuzheng , Li Jiuyang , Wang Xuepu , Zou Yunlong , Wang Biaobing , Zhang Kaka 
Published: September 2022

AbstractAqueous afterglow dispersions display promising biomedical applications due to their long‐lived excited states, whereas it is a common problem in the research field that processing and transferring solid‐state afterglow materials into aqueous medium can cause significant drop and even complete loss of their afterglow properties. Here, aqueous afterglow dispersions are fabricated from liquid precursors by dopant–matrix strategy and emulsion polymerization, which avoids the processing procedures on solid‐state materials and achieves 2.4 s long phosphorescence lifetimes in aqueous medium. Luminescent difluoroboron β‐diketonate dopants are first designed with small rate constant of phosphorescence decay and then dissolved in monomers. After emulsion polymerization, the as‐formed polymer latex particles not only assist dopants’ intersystem crossing but also provide a glassy microenvironment to largely suppress nonradiative decay of dopants’ triplets, leading to in situ formation of aqueous afterglow dispersions. This provides a robust method for constructing afterglow emulsions with long‐term colloidal stability, relatively high solid contents, tunable sizes, and diverse compositions. Through emulsion copolymerization, afterglow emulsions decorated with specific ligands are obtained to exhibit specific protein binding properties. Such decorated afterglow emulsions address the issue that afterglow materials lack biorecognition property and can pave the way for their applications in immunoassay and immunoimaging.
Bladder Cancer‐Derived Small Extracellular Vesicles Promote Tumor Angiogenesis by Inducing HBP‐Related Metabolic Reprogramming and SerRS O‐GlcNAcylation in Endothelial Cells
Authors: Li Xinyuan , Peng Xiang , Zhang Chunlin , Bai Xuesong , Li Yang , Chen Guo , Guo Huixia , He Weiyang , Zhou Xiang , Gou Xin 
Published: September 2022

AbstractA malformed tumour vascular network provokes the nutrient‐deprived tumour microenvironment (TME), which conversely activates endothelial cell (EC) functions and stimulates neovascularization. Emerging evidence suggests that the flexible metabolic adaptability of tumour cells helps to establish a metabolic symbiosis among various cell subpopulations in the fluctuating TME. In this study, the authors propose a novel metabolic link between bladder cancer (BCa) cells and ECs in the nutrient‐scarce TME, in which BCa‐secreted glutamine‐fructose‐6‐phosphate aminotransferase 1 (GFAT1) via small extracellular vesicles (sEVs) reprograms glucose metabolism by increasing hexosamine biosynthesis pathway flux in ECs and thus enhances O‐GlcNAcylation. Moreover, seryl‐tRNA synthetase (SerRS) O‐GlcNAcylation at serine 101 in ECs promotes its degradation by ubiquitination and impeded importin α5‐mediated nuclear translocation. Intranuclear SerRS attenuates vascular endothelial growth factor transcription by competitively binding to the GC‐rich region of the proximal promotor. Additionally, GFAT1 knockout in tumour cells blocks SerRS O‐GlcNAcylation in ECs and attenuates angiogenesis both in vitro and in vivo. However, administration of GFAT1‐overexpressing BCa cells‐derived sEVs increase the angiogenetic activity in the ECs of GFAT1‐knockout mice. In summary, this study suggests that inhibiting sEV‐mediated GFAT1 secretion from BCa cells and targeting SerRS O‐GlcNAcylation in ECs may serve as novel strategies for BCa antiangiogenetic therapy.
Unlocking Stable Multi‐Electron Cycling in NMC811 Thin‐Films between 1.5 – 4.7 V
Authors: Aribia Abdessalem , Sastre Jordi , Chen Xubin , Futscher Moritz H. , Rumpel Matthias , Priebe Agnieszka , Döbeli Max , Osenciat Nicolas , Tiwari Ayodhya N. , Romanyuk Yaroslav E. 
Published: September 2022

AbstractAmong cathode materials, LiNi0.8Mn0.1Co0.1O2 (NMC811) is the most discussed for high performance Li‐ion batteries, thanks to its capacity of ≈200 mAh g‐1 and low Co content. Here, it is demonstrated that NMC811 can reversibly accommodate more than one Li‐ion per formula unit when coupled with a solid‐state electrolyte, thus significantly increasing its capacity. Sputtered Li‐rich NMC811 cathodes are tested with lithium–phosphorus–oxynitride as a solid‐state electrolyte in a thin‐film architecture, which is a simplified 2D model with direct access to the cathode‐electrolyte interface. The solid‐state electrolyte helps to stabilize the interface and prevents capacity fading, voltage decay, and interface resistance growth, thus allowing cycling at extended voltage ranges of 1.5–4.7 V. While the liquid electrolyte cells suffer from rapid capacity decay, the Li‐rich NMC811 cells with the solid‐state electrolyte can cycle at a fast rate and an initial capacity of 149 mAh g‐1 from 1.5 to 4.3 V for 1000 cycles. The all‐solid‐state thin‐film cells with a lithium metal anode yield a discharge capacity of up to 350 mAh g‐1 at C/10 because of multi‐electron cycling with a coulombic efficiency of 90.1%. The results demonstrate how solid‐state electrolytes that are stable against NMC811 cathodes can unlock the full potential of this Li‐rich and Ni‐rich cathode class.
Selection of Redox Mediators for Reactivating Dead Li in Lithium Metal Batteries
Authors: Chen Jie , Cheng Zexiao , Liao Yaqi , Yuan Lixia , Li Zhen , Huang Yunhui 
Published: September 2022

AbstractLi metal batteries have suffered from dendrite growth and its derived dead Li formation for a long time. A new lithium restoration method through the shuttling of redox mediators has been proposed recently. However, the side reaction of severe self‐discharge often occurs when some redox mediators are used. Here, a selection principle of redox mediators for reactivating dead Li in lithium metal batteries is put forward, which is able to reactivate the dead Li effectively and reduce the self‐discharge at the same time. Three redox mediators of ferrocene (Fc), 10‐methylphenothiazine (MPT), and thianthrene (Th) with different redox potentials are tested in LiFePO4|Cu anode‐free Li metal batteries to clarify the selection principle. Furthermore, 2,2,6,6‐tetramethylpiperidinooxy (TEMPO), which is speculated to be a suitable one for reactivating dead Li in lithium metal batteries, is verified. This work provides a universal selection principle of redox mediators and may boost its practical application in Li metal batteries.
Accelerated Diffusion Kinetics in ZnTe/CoTe2 Heterojunctions for High Rate Potassium Storage
Authors: Zhang Chaofeng , Li Hao , Zeng Xiaohui , Xi Shibo , Wang Rui , Zhang Longhai , Liang Gemeng , Davey Kenneth , Liu Yuping , Zhang Lin , Zhang Shilin , Guo Zaiping 
Published: September 2022

AbstractPotassium‐ion batteries hold practical potential for large‐scale energy storage owing to their appealing cell voltage and cost‐effective features. The development of anode materials with high rate capability and satisfactory cycle lifespan, however, is one of the key elements for exploiting this electrochemical energy storage system at practical levels. Here, a template‐assisted strategy is reported for acquiring a bimetallic telluride heterostructure which is supported on N‐doped carbon shell (ZnTe/CoTe2@NC) that promotes diffusion of K+ ions for rapid charge transfer. It is shown that in telluride heterojunctions, electron‐rich Te sites and built‐in electric fields contributed by electron transfer from ZnTe to CoTe2 concomitantly provide abundant cation adsorption sites and facilitate interfacial electron transport during potassiation/depotassiation. The relatively fine ZnTe/CoTe2 nanoparticles imparted by the heterojunction result in high structural stability, together with a highly reversible capacity up to 5000 cycles at 5 A g−1. Moreover, using judiciously combined experiment and theoretical computation, it is demonstrated that the energy barrier for K+ diffusion in telluride heterojunctions is significantly lower than that in individual counterparts. This quantitative design for fast and durable charge transfer in telluride heterostructures can be of immediate benefit for the rational design of batteries for low‐cost energy storage and conversion.
New information and family relationship (Hymenophyllaceae) for the fossil fern genus Acrostichopteris Fontaine and a new species from the Lower Cretaceous (Albian) of Spain
Authors: Skog Judith E. , Sender Luis Miguel 
Published: September 2022

AbstractPremiseReinvestigation of previously described fossil plants using improved techniques can provide insights for additional characters resulting in better family assignments and relationships to modern plants, as in this new study of the fossil fern Acrostichopteris from the mid‐Cretaceous. The discovery of new species within genera provides additional characteristics for comparisons and support for family assignments.MethodsFossil material was uncovered from the matrix (degagement) for the specimens described here. Material was removed from the matrix and mounted for examination by scanning electron microscopy (SEM). Spores were extracted and prepared for examination with light, fluorescence, and SEM. Characters for the previously described material from the Potomac Group in the USA and the new material from Spain were compared with those of other fossils assigned to the genus.ResultsThe genus, described by Fontaine in 1889, reexamined by Berry in 1911, and assigned to the Schizaeaceae by Reed in 1947, is reassigned to the family Hymenophyllaceae on the basis of characteristics of the pinnules, sori, sporangia, and spores. We describe a new species in the genus from the Lower Cretaceous (Albian) of Spain that most likely belongs in this family, based on characteristics of the pinnules and the sori. A summary of all the species previously assigned to the genus is included.ConclusionsAssignment of this fossil to the family Hymenophyllaceae is based on all characters known and comparison to modern species, provides the time for appearance of characteristics within the family, and indicates diversification of Hymenophyllum species in the mid‐Cretaceous.
Diverse ecological functions and the convergent evolution of grass awns
Authors: Petersen Kurt B. , Kellogg Elizabeth A. 
Published: September 2022

AbstractThe awn of grasses is a long, conspicuous outgrowth of the floral bracts in a grass spikelet. It is known to impact agricultural yield, but we know little about its broader ecological function, nor the selective forces that lead to its evolution. Grass awns are phenotypically diverse across the extant ~12,000 species of Poaceae. Awns have been lost and gained repeatedly over evolutionary time, between and within lineages, suggesting that they could be under selection and might provide adaptive benefit in some environments. Despite the phylogenetic context, we know of no studies that have tested whether the origin of awns correlates with putative selective forces on their form and function. Presence or absence of awns is not plastic; rather, heritability is high. The awns of grasses often are suggested as adaptations for dispersal, and most experimental work has been aimed at testing this hypothesis. Proposed dispersal functions include soil burial, epizoochory, and aerial orientation. Awns may also protect the seed from drought, herbivores, or fire by helping it become buried in soil. We do not fully understand the fitness or nutrient costs of awn production, but in some species awns function in photosynthesis, providing carbon to the seed. Here we show that awns likely provide an adaptive advantage, but argue that studies on awn function have lacked critical phylogenetic information to demonstrate adaptive convergent evolution, are taxonomically biased, and often lack clear alternative hypotheses.
Association of Cortical Superficial Siderosis with Post‐Stroke Epilepsy
Authors: Tanaka Tomotaka , Fukuma Kazuki , Abe Soichiro , Matsubara Soichiro , Ikeda Shuhei , Kamogawa Naruhiko , Ishiyama Hiroyuki , Hosoki Satoshi , Kobayashi Katsuya , Shimotake Akihiro , Nakaoku Yuriko , Ogata Soshiro , Nishimura Kunihiro , Koga Masatoshi , Toyoda Kazunori , Matsumoto Riki , Takahashi Ryosuke , Ikeda Akio , Ihara Masafumi 
Published: September 2022

ObjectiveTo assess whether post‐stroke epilepsy (PSE) is associated with neuroimaging findings of hemosiderin in a case–control study, and whether the addition of hemosiderin markers improves the risk stratification models of PSE.MethodsWe performed a post‐hoc analysis of the PROgnosis of POST‐Stroke Epilepsy study enrolling PSE patients at National Cerebral and Cardiovascular Center, Osaka, Japan, from November 2014 to September 2019. PSE was diagnosed when one unprovoked seizure was experienced >7 days after the index stroke, as proposed by the International League Against Epilepsy. As controls, consecutive acute stroke patients with no history or absence of any late seizure or continuing antiseizure medications at least 3 months after stroke were retrospectively enrolled during the same study period. We examined cortical microbleeds and cortical superficial siderosis (cSS) using gradient‐echo T2*‐weighted images. A logistic regression model with ridge penalties was tuned using 10‐fold cross‐validation. We added the item of cSS to the existing models (SeLECT and CAVE) for predicting PSE and evaluated performance of new models.ResultsThe study included 180 patients with PSE (67 women; median age 74 years) and 1,183 controls (440 women; median age 74 years). The cSS frequency was higher in PSE than control groups (48.9% vs 5.7%, p < 0.0001). Compared with the existing models, the new models with cSS (SeLECT‐S and CAVE‐S) demonstrated significantly better predictive performance of PSE (net reclassification improvement 0.63 [p = 0.004] for SeLECT‐S and 0.88 [p = 0.001] for CAVE‐S at the testing data).InterpretationCortical superficial siderosis was associated with PSE, stratifying stroke survivors at high risk of PSE. ANN NEUROL 2023;93:357–370
Applying a Circular Economy to the Water Community: A Holistic Approach
Authors: Richardson Colby , Sham Chi Ho 
Published: September 2022

Key TakeawaysThe water community's continued adherence to a traditional, use‐and‐discard linear economy could be detrimental to the environment and the global population.Circular economies realize financial and ecological benefits by fully optimizing resources and products through reduction of materials and waste, recovery of materials for reuse, and recycling.By espousing the practices of a circular economy, with water reuse at its core, water utilities can contribute to economic and environmental well‐being and help protect a threatened resource.
Determination of six core components from Mahuang Xuanfei Zhike syrup in rat plasma and tissues by UPLC–MS/MS: Application to a pharmacokinetics and tissue distribution study
Authors: Yang Yang , Zhu Jing , Yao Chang‐liang , Guo De‐an , He Na , Mei Quan‐xi , Feng Guang‐jun , Chen Qin‐hua , Yang Guang‐yi 
Published: September 2022

AbstractMahuang Xuanfei Zhike (MXZ) syrup, a Chinese patent medicine, has been widely used in the clinical treatment of cough. However, there is no reported method for the quantitative analysis of the effective components of MXZ syrup in biological samples. In this study, the effective components of MXZ syrup were screened by network pharmacology and molecular docking technology. A sensitive and rapid ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was established to test the active components of MXZ syrup in rat plasma and tissue homogenates, including ephedrine, amygdalin, chlorogenic acid, harpagoside, forsythin and forsythoside A. Chromatographic separation was performed on a Waters Acquity UPLC HSS T3 column (2.1 × 50 mm, 1.8 μm) and the mass analysis was conducted using a Waters Xevo TQ mass spectrometer using multiple reaction positive and negative ion simultaneous monitoring mode. The results showed that the linearity ranged from 0.3 to 409.4 ng/ml. The extraction recoveries were all <8.33%, and the matrix effects were all <8.45, which met the requirements. The pharmacokinetic and tissue distribution results indicated that the main active components of MXZ syrup were absorbed quickly and eliminated slowly in vivo, and there may be a reabsorption process.
Palladin promotes cancer stem cell‐like properties in lung cancer by activating Wnt/Β‐Cateninsignaling
Authors: Shu Xiong , Chen Meng , Liu Shi‐Ya , Yu Long , Sun Li‐Xin , Sun Li‐Chao , Ran Yu‐Liang 
Published: September 2022

AbstractBackgroundCancer stem cells (CSCs) are responsible for drug resistance, cancer relapse, and metastasis. Here, we report the first analysis of Palladin expression and its impacts on stem cell‐like properties in lung cancer.MethodsTissue microarrays were used to investigate Palladin expression and its association with prognosis. Immunofluorescence (IF), flow fluorescence assay, and Western blot were performed to detect Palladin expression in 6 NSCLC cell lines. Cell phenotypes and drug resistance were evaluated. Xenograft models were constructed to confirm the role of Palladin in vivo.ResultsBy using the tissue microarrays, Palladin was identified to be highly expressed in the cytoplasm, specifically in the cytomembrane of NSCLC, and its high expression is associated with poor prognosis. Palladin is widely expressed and enriched in the sphere cells. The in vitro and in vivo studies showed that Palladin promoted stem cell‐like properties, including cell viability, invasion, migration, self‐renewal abilities, taxol resistance, and tumorigenicity. Western blot revealed that Palladin promoted the accumulation of β‐catenin and activated Wnt/β‐catenin signaling. Tissue microarrays analysis further confirmed the positive correlation between Palladin and β‐catenin. Wnt/β‐catenin pathway inhibitor blocked the Palladin‐induced enhancement of sphere‐forming.ConclusionsPalladin might act as an oncogene by promoting CSCs‐like properties and tumorigenicity of NSCLC cells via the Wnt/β‐catenin signaling pathway. Besides, Palladin was identified to have the potential as a cell surface marker for LCSCs identification. These findings provide a possible target for developing putative agents targeted to LCSCs.
SARS‐CoV‐2 vaccines: A double‐edged sword throughout rapid evolution of COVID‐19
Authors: Zolfaghari Mohammad Ali , Ghadiri Moghaddam Farzaneh , Rajput Shabnam , Karimi Abbas , Naghi Vishteh Mohadeseh , Mahmoodpoor Ata , Dolati Sanam , Yousefi Mehdi 
Published: September 2022

AbstractAfter more than 2 years of the coronavirus disease 2019 pandemic caused by severe acute respiratory syndrome coronavirus 2, several questions have remained unanswered that affected our daily lives. Although substantial vaccine development could resist this challenge, emerging new variants in different countries could be considered as potent concerns regarding the adverse effects of reinfection or postvaccination. Precisely, these concerns address some significant and probable outcomes in vaccinated or reinfected models, followed by some virus challenges, such as antibody‐dependent enhancement and cytokine storm. Therefore, the importance of evaluating the effectiveness of neutralizing antibodies (nAbs) elicited by vaccination and the rise of new variants must be addressed.
Effect of selenium biofortification on bioaccessibility, antioxidant, and antimicrobial potentials of phenolic compounds in germinated black soybean (Glycine max (L.) Merr)
Authors: Huang Junyi , Yang Jingyi , Miao Qianqian , Olajide Tosin Michael , Qian Jiana , Liu Haoyue , Ou Pengcheng , Liao Xianyan 
Published: September 2022

AbstractBackground and ObjectiveBiofortification with inorganic selenium has become a key strategy to enhance selenium content in crops. This study aimed to investigate the changes of phenolic compounds and their effects on antimicrobial and antioxidant activities during in vitro digestion of selenium biofortified germinated black soybeans (GBS‐Se).FindingsThe bioaccessibility of total polyphenols and total flavonoids in GBS‐Se were significantly lower than those of germinated black soybeans (GBS). p‐Coumaric acid and salicylic acid in GBS‐Se and GBS increased significantly in the oral phase; syringic acid and benzoic acid were the main phenolic acids in the gastric phase, while phenolic acids decreased continuously in the intestinal phase. There was some minor difference between the antioxidant activities of GBS‐Se and GBS in vitro digested products, but their 2,2'‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS) scavenging and ferric reducing antioxidant power reducing capacities increased compared with those before digestion. In addition, inhibitory effects on Escherichia coli and Staphylococcus aureus were observed only in undigested black soybean phenolic extracts.ConclusionsSelenium fortification affected the phenolic compounds and their bioaccessibility of GBS, which should be considered in nutrition research.Significance and NoveltyThese results could help systematically evaluate the effect of selenium fortification on the digestibility of phenolic compounds in GBS and provide a reference for the development and application of Se‐enriched functional foods.
Den Gips durch das Rohr geblasen
Authors: Sienk Thorsten 
Published: September 2022

AbstractFür den Transport des gebrannten und fein gemahlenen Natursteins zwischen Gips‐ und Faserplattenwerk kommt bei Knauff ein Rohrleistungssystem zum Einsatz. Schraubenverdichter vom Aerzen Typ Delta Screw sorgen bei der pneumatischen Förderung für die energieeffiziente Druckluft und Volumenstrom des Schüttguts.
Silan‐modifizierte Polymere in Kleb‐ und Dichtstoffen
Authors: Schäfer Sascha , Damke Jan‐Erik 
Published: September 2022

ZusammenfassungSMPs haben eine eindrucksvolle Entwicklung seit den 1990er Jahren bis heute genommen. Im Markt für elastisches Kleben sind sie überproportional gewachsen und haben sich als fester Bestandteil etabliert. War dieser anfangs nur von einem Hersteller dominiert, haben sich über die Jahre immer mehr Firmen ein eigenes SMP‐Präpolymer‐ oder Produkt‐Portfolio aufgebaut. SMPs haben sich aus der Bauindustrie heraus in viele weitere Anwendungsfelder für elastische Fügemethoden weiterentwickelt. Sie zeichnen sich durch Vorteile wie Variabilität, einfache und sichere Handhabung, hohe Beständigkeit gegenüber Umwelteinflüssen und formbare Ästhetik aus. Das wichtigste Anwendungsfeld bleibt auch in naher Zukunft die Bau‐ und Heimwerkerindustrie. Zunehmend profitieren jedoch die Fahrzeug‐ und Maschinenbauindustrie von den Lösungen der elastischen Verklebungen und Dichtungen auf der Grundlage von SMPs.