bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forming the development of a value relationship to a healthy lifestyle among future primary school teachers based on healthcare technology
Authors: Akzaru Espanova , Uaisova Gulnar , Zhakenkyzy Kurman Nesibeli , Kalimukhasheva Bagit , Koshkin Erkebulan , Kurmanbekova Aigul 
Published: November 2022

The aim of this study is to obtain the opinions of prospective teachers in order to create the development of the value relationship between the healthy lifestyle and the value of future primary school teachers based on health technology. This research was created in accordance with the qualitative research method. The study group of the research consists of 25 teacher candidates studying in primary school teaching departments in various universities in Kazakhstan. The data collection tool for the research is the semi-structured interview form developed by the researchers. As a result of the research, future primary school teachers stated that they had a healthy lifestyle, balanced and healthy nutrition, regular exercise, avoided harmful habits like alcohol and smoking, avoided stress, protected mental and emotional health and acquired regular sleep habits. They stated that technological devices are used in the field of health, health technology shortens the healing process, facilitates health practices, saves time, requires professional application and use and increases awareness. Moreover, the majority of future primary school teachers stated that they strongly support the development of the value relationship with a healthy lifestyle based on health technology.
Keywords: Healthy life, health technology, primary school teachers of the future;
Robotic-based takraw blocker technique skill tool: Development and students’ perceptions
Authors: Arwandi John , Bais Syahril , Soniawan Vega , Sari Suci Nanda , Padli Padli , Ridwan M. 
Published: November 2022

The purpose of this research is to develop a robotic-based block takraw technique skill tool. This research method is a development that uses the ADDIE model. The sample in this study comprised 25 athletes. The research instrument used was an expert validation questionnaire and a student perception questionnaire. The data analysis technique used is descriptive statistics for quantitative data and Miles and Huberman’s technique for qualitative data. The results of expert validation of exercise measurement and evaluation tests, takraw expert validation and media expert validation showed very good results where the product developed was feasible to use. The results of students’ perceptions of the robotic-based block takraw technique skills showed very good results as well. Therefore, this robotic-based block takraw technique skill tool is very good as a supporting tool in training to improve the smash ability of takraw athletes.
Keywords: Blocker Technique; Development; Perception; Robotics; Skill tool; Takraw
PASIEN SINDROMA APERT YANG DILAKUKAN OPERASI FRONTO ORBITAL ADVANCEMENT SETELAH OCCIPITAL EXPANSION
Authors: Putria Almahitta Cintami Putria , Prasetyo Arif Tri Prasetyo , Amelia Febrina  
Published: November 2022

Sindroma Apert atau acrocephalosyndactyly tipe I merupakan kelainan kongenital yang ditandai dengan adanya kraniosinositosis, exorbitism, midface hypoplasia dan sindaktili simetris pada tangan dan kaki, hal ini disebabkan oleh mutasi genetik dari FGFR-2, S252W dan P253R. Tatalaksana kraniosinostosis bertujuan untuk memperbaiki fungsi serta estetik dari pasien dengan tindakan awal adalah dilakukan dekompresi kalvaria dengan intervensi pembedahan yaitu occipital expansion pada usia 6 bulan dan dilanjutkan dengan fronto-orbital-advancement (FOA). Pada kasus ini dilakukan tatalaksana occipital expansion dan dilanjutkan dengan FOA dengan hasil yang cukup memuaskan.
PROTOTYPE ALAT NOTIFIKASI KETINGGIAN AIR DAN PEMUNGUTAN SAMPAH OTOMATIS ANTISIPASI BANJIR DENGAN SENSOR ULTRASONIK WITH GLOBAL SYSTEM FOR MOBILE COMMUNICATIONS
Authors: Kharisma Hidayah Agung , Apriza Ririn , Toyib Rozali 
Published: November 2022

Gubernur Rohidin meminta agar Pemerintah Kota Bengkulu harus memperketat perizinan pembangunan perumahan sehingga masih tersedia ruang terbuka hijau, perbaiki Daerah Aliran Sungai (DAS) dengan ekosistemnya dan rutin pemberisihan sampah-sampai yang menyubat drenase di dalam kota dan pintu-pintu air yang masuk dari aliran sungai yang masuk ke Kota Bengkulu yang menyebabkan banjir karena terjadi hujan di hulunya dan tidak adanya peringatan dini ketika air mencapai kota Bengkulu serta banyaknya sampah-sampah yang menyumbat di pintu-pintu air semakin memperparah kondisi. Prototype alat notifikasi ketinggian air sistem for mobile Communication yang memungkinkan pemberitahuan dini bila di pintu air terjadi kenaikan ketinggian sehingga masyarakat bisa waspada serta dirancang juga alat pemungutan sampah otomatis dengan sensor ultrasonic yang bisa mendeteksi sampah yang mendekati di pintuh air dengan jarak yang telah ditentukan. Hasil pengujian ada notifikasi yang telah dilakukan dapat mengirim Sms Secara 0tomatis ke nomor tujuan dan mengeluarkan alarm kemudian mengeluarkan suara speaker sebagai petanda adanya ketinggian air. benda yang dapat dipungut oleh konveyor tersebut yaitu berupa sampah sampah yang ringan yang berda di permukaan air. Sistem informasi robot yang berupa LCD yang akan menampilkan hasil ketinggian air tersebut
Robust and Efficient Identification of Hydraulic Flow Units using Differential Evolution Optimization and Two-Stage Clustering Techniques
Authors: Al-Ismael Menhal A. , Awotunde Abeeb A. 
Published: November 2022

Summary
One essential process in reservoir characterization is the identification of hydraulic flow units (HFUs). It plays a critical role in determining hydrocarbon reserves and improving reservoir productivity. Flow zone indicator (FZI), determined from core data, is widely used to identify HFUs. One of the challenges in the FZI technique is that the number of HFUs is identified using qualitative methods and subjective estimation. This work proposes robust methods to identify the optimal HFUs using differential evolution (DE) and two-stage clustering. The first method tested in this work enumerates through a large number of HFUs scenarios using 10 clustering algorithms and different input parameters (number of clusters, minimum number of samples, etc.). The scenario with the largest average correlation coefficient is selected as optimum. The second method uses the DE algorithm to maximize the average correlation coefficient and hence obtain the optimal HFUs. The third method consists of two stages. The first stage uses the OPTICS clustering algorithm to determine the number of HFUs, while the second stage generates the desired clusters using the Gaussian mixture algorithm. Both iterative evaluation and DE optimization methods achieved the same clustering results. However, DE optimization resulted in 85% reduction in runtime due to the robust search capability of the DE algorithm which leads to the solution more efficiently. Furthermore, another significant reduction in runtime was achieved using the two-stage clustering method which yielded very close results. The proposed methods in this work provide unique and potential opportunity to improve the use of FZI data analysis to identify HFUs. This work uses the power of clustering and stochastic algorithms to support a critical process in reservoir characterization.
Experiments on the Novel Chord-Edge Cutter to Break Rock with Higher Efficiency and Its Field Application
Authors: Yang Bo , Kuang Yuchun , Jingpei Zhou , Hu Li , Fan Peng 
Published: November 2022

Summary
Aiming at the difficulty of penetration in hard-plasticity formation represented by the Mahu oil field, a new type of chord-edge cutter is proposed. Through theoretical derivation and quantitative analysis of specific unit pressure (SUP) and breaking area, the penetration and rock-breaking area of the chord-edge cutter are studied, which clarifies that the rock-breaking efficiency of the chord-edge cutter is higher than that of the conventional cutter. The first part of the laboratory experiment investigated the drilling efficiency of two mini-bits on a special sample. The results show that the chord-edge cutter mini-bit has higher efficiency than a conventional mini-bit. The second part of the laboratory experiment investigated the influence of rate of penetration (ROP), revolutions per minute (RPM), and rock types on the drilling performance of chord-edge cutter mini-bit. The data show that the chord-edge cutter is more suitable for drilling hard-plastic rocks. It also reveals that the higher the RPM, the lower the stick/slip vibration, but the RPM above a certain value will lead to an increase in lateral vibration. ROP and weight on bit (WOB) are positively correlated. And the higher the drilling speed, the higher the stick/slip vibration and lateral vibration. To verify these conclusions, a field test is carried out in the hard-plastic formation of a well in the Mahu. In this test, compared with a conventional polycrystalline diamond compact (PDC) bit, a roller-cone bit, and a hybrid bit, the chord-edge cutter bit has the best drilling effect. Further, it is found that when using the chord-edge cutter bit, the high RPM and proper control of WOB can achieve a better drilling efficiency. This rule is mutually confirmed with the conclusion of the laboratory experiment. After the above research and its implementation, it can be concluded that the novel chord-edge cutter bit can achieve the research goal of higher efficiency, which provides a new idea to overcome challenges in the hard-plastic strata.
Seasonal Gene Expression Profile Responsible for Hair Follicle Development in Angora goats
Authors: Kul Bengi Cinar , Bilgen Nuket , Biskin Merve , Akkurt Mustafa Yenal , Cildir Ozge Sebnem , Ozmen Ozge , Kul Oguz 
Published: November 2022

Abstract

Background: Mammals have physiological reprogramming adaptation ability to changing seasonal light and temperature, through their biological clocks maintained by circadian rhythm, photoperiodism and thermoperiodism. These seasonal differences do not only affect vital activities of animals like migration, reproduction, sleeping, but also cause dramatic changes in their economically important characters (e.g. fur quality, fattening levels and milk yield). Mohair is constituted of non-medullary hairs produced by secondary hair follicles in Angora goats and the effects of seasonal differences on mohair structure and related genes are still unknown.
Methods and Results: We examined the gene expression levels of BMP-2, FGF-5, HOXC13, KAP9.2 and TGFBR2 normalized with GAPDH in skin biopsies taken from Angora goats (n=20) in two different follicle development stages; telogen and anagen, sampled in February and June, respectively. HOXC13 showed high level of expression in anagen phase whereas expression was undetectable in telogen phase. TGFBR2, FGF-5, and BMP-2 were significantly upregulated in anagen, while KAP9.2 expression showed no difference between two phases.
Conclusions: This is the first study on hair follicle-related genes in the angora goat and revealed that these genes differ between geographic zones and/or breeds. Additionally, we speculate that overexpression of HOXC13 might be one of the underlying factors associated with non-medullary hair nature, making the mohair more shiny and silky in Angora goats.
Treatment for non-type 1 retinopathy of prematurity by intravitreal injection of anti-vascular endothelial growth factor drugs
Authors: Zhang Haitao , Yang Xin , Zheng Fangfang , Yin Xiangke , Wan Suhua 
Published: November 2022

Abstract
Background: To explore clinical characteristics and treatment reasonsfor intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) drugs in the treatment of non-type 1 retinopathy of prematurity (ROP).
Methods: A retrospective study was conducted to screen the non-type 1 ROP from the collected ROP patients who received intravitreal injection of anti-VEGF drugs in Henan Eye Hospital from September 2018 to June 2021.
Results: A total of 138 ROP cases (262 eyes) were included in this study, including 39 cases (28.3%) 65 eyes (24.8%) were the non-type 1 ROP. Compared with the type 1 ROP group, the non-type 1 ROP group had slightly later treatment time (39.8±2.7 weeks vs 38.1±2.6 weeks, P<0.05) and a higher proportion of fusion protein drugs (87.2% vs 54.5%, P<0.05). After intravitreal injection of anti-VEGF drugs, 27 eyes (41.5%) were cured and 38 eyes (58.5%) were improved in the non-type 1 ROP group, without recurrence and aggravation cases. There were more lesions in zone II (63 eyes, 96.9%), with stage 2 (40 eyes, 61.5%) and stage 3 (23 eyes, 35.4%), and 58 eyes (89.2%) showed pre-plus in the non-type 1 ROP group. Treatment reasons included pre-plus in 58 eyes (89.2%), ridge aggravation in 22 eyes (33.8%), simultaneous treatment of the contralateral eye in 9 eyes (13.8%), no regression of lesions in persistent stage 2 or 3 over PMA 44 weeks of follow-up in 8 eyes (12.3%), and logistical considerations in 4 eyes (6.2%).
Conclusions: Considering some peculiar clinical characteristic, treatment by intravitreal injection of anti-VEGF drugs may be considered carefully for some non-type 1 ROP in critical conditions.
Spindle cell melanoma masquerading as a lipoma: an interesting presentation of a rare cancer
Authors: Lamm Ryan , Lyons Walker , Gargano Stacey M , Willis Alliric I 
Published: November 2022

Abstract
Background: Overall survival is directly correlated to melanoma thickness and definitive surgical excision. Spindle cell melanoma is a rare subtype of malignant melanoma and particularly difficult to diagnose. Identification of histopathological features and referral to specialists are essential.
Case presentation: We describe the case of an 86-year-old male who presented to his family medicine physician with complaints of a large 40 mm mass on his right posterior trunk which was clinically diagnosed as a lipoma. This mass was subsequently removed in his family physician’s office as an office procedure. Less than eight months post-excision, the tumor had erupted through the incision site. At time of surgical oncologist evaluation, the tumor was pedunculated and measured 92 mm at its greatest diameter. This tumor was subsequently biopsied to reveal spindle cell melanoma with thickness of at least 22 mm. Wide local excision was performed with complete removal of the tumor with negative margins.
Conclusion: Our report supports the importance of early and correct diagnosis of cutaneous melanoma which can often be mistaken for other cutaneous lesions, both benign and malignant. In these situations, it is important to obtain a tissue biopsy and consult with specialists in pathology and surgical oncology/dermatology to ensure timely, appropriate treatment.
Diabetes during the COVID-19 pandemic: are people getting access to the right level of care?
Authors: Meyerowitz-Katz Gideon , Ferdousi Shahana , Maberly Glen , Astell-Burt Thomas 
Published: November 2022

Abstract
Introduction
Avoidance of health services, in particular hospital and community services, is problematic for people with diabetes. Evidence has demonstrated that such missed attendances are associated with worse health, faster declines in functioning, and higher rates of mortality long-term.
This paper investigated the impact of the pandemic on healthcare access across community and hospital care, including Virtual Care (VC) using several large datasets of General Practice (GP) and hospital services in western Sydney.
Methods
A retrospective cohort study using a time-series database of 173,805 HbA1c tests done at Blacktown and Mt Druitt hospitals and 1.8 million recorded consultations at GP clinics in the region was undertaken.
Results
The average rate of diabetes in Emergency Department fell from 17.8% pre-pandemic to 11% after January 2020 (p<0.001). This rate varied substantially over time, and correlated well with large outbreaks of COVID-19 in the state. Conversely, attendances of people with diabetes to GP clinics, especially using VC services, increased substantially over the pandemic period.
Discussion/Conclusion
During the pandemic there was a substantial avoidance of hospital care by patients with diabetes. However, this may have been replaced by VC offered in the community for those with less severe diseases.
Predicting hepatotoxicity associated with low-dose methotrexate using machine learning
Authors: Hu Qiaozhi , Wang Hualing , Xu Ting 
Published: November 2022

Abstract
Purpose
An accurate prediction of the hepatotoxicity associated with low-dose methotrexate can provide evidence for a reasonable treatment choice. This study aimed to develop a machine learning-based prediction model to predict hepatotoxicity associated with low-dose methotrexate and explore the associated risk factors.
Methods
Eligible patients with immune system disorders, who received low-dose methotrexate at West China Hospital between January 1, 2018, and December 31, 2019, were enrolled. A retrospective review of the included patients was conducted. Risk factors were selected from multiple patient characteristics, including demographics, admissions, and treatments. Eight algorithms, including eXtreme Gradient Boosting (XGBoost), AdaBoost, CatBoost, Gradient Boosting Decision Tree (GBDT), Light Gradient Boosting Machine (LightGBM), Tree-based Pipeline Optimization Tool (TPOT), Random Forest (RF), and Artificial Neural Network (ANN), were used to establish the prediction model.
Results
A total of 782 patients were included, and hepatotoxicity was detected in 35.68% (279/782) of the patients. The Random Forest model with the best predictive capacity was chosen to establish the prediction model (receiver operating characteristic curve 0.97, accuracy 64.33%, precision 50.00%, recall 32.14%, and F1 39.13%). Among the 15 risk factors, the highest score was a body mass index of 0.237, followed by age (0.198), the number of drugs (0.151), and the number of comorbidities (0.144). These factors demonstrated their importance in predicting hepatotoxicity associated with low-dose methotrexate.
Conclusion
Using machine learning, this novel study established a predictive model for low-dose methotrexate-related hepatotoxicity. The model can improve medication safety in patients taking methotrexate in clinical practice.
Single center retrospective subgroup analysis of “primary aortic” (aneurysm, aortic dissection, PAU) and “secondary aortic” (iatrogenic, trauma and aortoesophageal fistula) indications for emergency TEVAR
Authors: Rebelo Artur , Partsakhashvili Jumber , Ronellenfitsch Ulrich , John Endres , Kleeff Jörg , Ukkat Jörg 
Published: November 2022

Abstract
Background
The aim of the study was to analyse the outcome of emergency thoracic endovascular aortic repair (TEVAR) in the treatment of “primary aortic” (aneurysm, aortic dissection, penetrating aortic ulcer [PAU]) and “secondary aortic” (iatrogenic, trauma and aortoesophageal fistula) pathologies.
Methods
Retrospective review of a cohort of patients treated at a single tertiary referral center from 2015 to 2021. Primary end point was postoperative in-hospital mortality. Secondary end points were the duration of the procedure, duration of postoperative intensive care treatment, length of hospital stay, and the nature and severity of postoperative complications according Dindo-Clavien Classification
Results
A total of 34 patients underwent TEVAR for emergency indications. 22 patients were treated for primary and 12 patients for secondary aortic pathologies. Concerning in-hospital mortality, no statistically significant difference could be observed between the primary and secondary aortic groups (27.3% vs 33.3%, p = 0.711). Patients with aortoesophageal fistula had a mortality rate of 66.7%. Postoperative morbidity (Dindo-Clavien > 3) was also not statistically significant different between the aortic and non-aortic groups (36.4% vs 33.3%, p = 0.86). Preoperative hemoglobin level (mmol/L) (p < 0.001), postoperative creatinine level (umol/L) (p = 0.009) and pre- and postoperative lactate levels (p < 0.001) were found to be independent factors associated with early mortality and morbidity (Dindo-Clavien > 3).
Conclusions
Morbidity and in-hospital mortality are still considerable after emergency TEVAR, for both aortic and non-aortic indications. Pre- and postoperative levels of hemoglobin, creatinine and lactate may be valuable to predict the patient outcomes.
Oral Manifestations of COVID-19: A Questionnaire-Based Survey of the Mild and Moderate Cases in the Turkish Population
Authors: Ünallı K. Esra , Gedik Ecem , Yazar Ezgi , Çandırlı Celal 
Published: November 2022

Abstract
BACKGROUND
A myriad of symptoms associated with COVID-19 have been reported in the literature. It's currently unclear if these symptoms are part of a normal clinical pattern directly induced by SARS-CoV-2 infection or are secondary to the patient's compromised systemic condition, given the probability of coinfections, immunosuppression, and treatment-related adverse effects (4). The aim of this research was to find answers to the question"What is the prevalence of oral symptoms in COVID-19 patients?“.
METHODS
A questionnaire was designed to detect and identify changes in the oral mucosa in patients with COVID-19 infection. During their follow-up at the Gölcük State Hospital COVID Outpatient Clinic, clinicians and an academic specialist performed a face-to-face survey of the patients. Participants were informed about the purpose of the study and their consent to participate in the study was obtained along with their signatures on the questionnaire form. The data was collected between April 12 and May 22, 2020, and it was analyzed, archived, and processed anonymously.
RESULTS
This survey included 306 COVID-19 patients in total. The results revealed that only 29.4% of respondents had complaints of oral aphthae and ulcers and 18.94% experienced oral pain; with the most commonly reported symptom being xerostomia (67,6%). There was a widespread distribution of reported symptoms with varying incidences and locations.
CONCLUSION
Analyzing the data this study procured, one still can’t conclusively determine whether the oral manifestations develop secondary to COVID-19.