bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Switch From Intravenous to Oral Antibiotics in Skin and Soft Tissue Infections: An Algorithm-Based Prospective Multicenter Pilot Trial
Authors: Dellsperger Sandra , Kramer Simea , Stoller Michael , Burger Annika , Geissbühler Elio , Amsler Isabel , Hirsig Anna , Weyer Linda , Hebeisen Ursula , Aebi Philipp , Burgherr Nicolas , Brügger Fabienne , Chaix Edouard , Salamoni Jérôme , Glauser Sandra , Büchi Annina Elisabeth , Béguelin Charles , Waldegg Gabriel , Kessler Bernhard , Egger Martin , Sendi Parham 
Published: April 2022

AbstractBackgroundIn hospitalized patients with skin and soft tissue infections (SSTIs), intravenous (IV) empiric antibiotic treatment is initiated. The best time point for switching from IV to oral treatment is unknown. We used an algorithm-based decision tree for the switch from IV to oral antibiotics within 48 hours and aimed to investigate the treatment outcome of this concept.MethodsIn a nonrandomized trial, we prospectively enrolled 128 patients hospitalized with SSTI from July 2019 to May 2021 at 3 institutions. Clinical and biochemical response data during the first week and at follow-up after 30 days were analyzed. Patients fulfilling criteria for the switch from IV to oral antibiotics were assigned to the intervention group. The primary outcome was a composite definition consisting of the proportion of patients with clinical failure or death of any cause.ResultsNinety-seven (75.8%) patients were assigned to the intervention group. All of them showed signs of clinical improvement (ie, absence of fever or reduction of pain) within 48 hours of IV treatment, irrespective of erythema finding or biochemical response. The median total antibiotic treatment duration was 11 (interquartile range [IQR], 9–13) days in the invention group and 15 (IQR, 11–24) days in the nonintervention group (P &lt; .001). The median duration of hospitalization was 5 (IQR, 4–6) days in the intervention group and 8 (IQR, 6–12) days in the nonintervention group (P &lt; .001). There were 5 (5.2%) failures in the intervention group and 1 (3.2%) in the nonintervention group after a median follow-up of 37 days.ConclusionsIn this pilot trial, the proposed decision algorithm for early switch from IV to oral antibiotics for SSTI treatment was successful in 95% of cases.Clinical Trials Registration. ISRCTN15245496
Tuberculosis Among Patients With Systemic Lupus Erythematosus in Indonesia: A Cohort Study
Authors: Hamijoyo Laniyati , Sahiratmadja Edhyana , Ghassani Nadia G , Darmawan Guntur , Susandi Evan , van Crevel Reinout , Hill Philip C , Alisjahbana Bachti 
Published: April 2022

Abstract

Background
In previous studies, researchers have identified systemic lupus erythematosus (SLE) as a risk factor for tuberculosis (TB), but data from TB-endemic countries are still relatively scarce. We examined TB in a large cohort of SLE patients in Indonesia.

Methods
All patients registered in a lupus registry of the top referral hospital for West Java between 2008 and 2020 were included. Data on SLE characteristics and treatment were retrieved from the registry, and data on TB diagnosis, localization, and outcome were extracted from medical records. Cox-proportional hazard model was used to examine risk factors for development of TB.

Results
Among 1278 SLE patients observed over a total of 4804 patient-years, 131 patients experienced 138 episodes of TB, a median of 2 years (interquartile range, 0.6–5.4) after diagnosis of SLE. A total of 113 patients (81.9%) had pulmonary involvement and 61 (44.2%) had extrapulmonary involvement, with disseminated disease in 26 of 138 episodes (18.8%), and 13 of 131 patients (9.9%) died from TB. The estimated TB incidence was 2873 cases per 100 000 person years. In multivariate cox regression analysis, development of TB was associated with household TB contact (hazard ratio [HR], 7.20; 95% confidence interval [CI], 4.05–12.80), pulse methylprednisolone therapy (HR, 1.64; 95% CI, 1.01–2.67), and age ≤25 years old at SLE diagnosis (HR, 1.54; 95% CI, 1.00–2.35).

Conclusions
There is a high burden of TB in SLE patients in this TB-endemic setting, underlining the need for evaluation or implementation of TB preventive strategies.
Efficacy of soursop juice extender on rooster semen quality, oxidative activity and spermatozoa kinematics
Authors: Jimoh Olatunji Abubakar , Nwachukwu Chinwe Uchechi 
Published: April 2022

Abstract
African medicinal plant like soursop (Annona muricate L.) within annonaceae are known for their biological, therapeutic, and pharmacological properties with little or no toxicity. The use of such plant requires good knowledge of the toxicity dosage, purity, suitable extraction solvent and adverse effects. The leaves, seeds, fruits, barks, and roots of African medicinal plants have been used for various nutraceuticals and functional effects according to African folk medicine. The aim of this study is to evaluate the semen quality, oxidative activity and spermatozoa kinematics of rooster semen in soursop juice extender. About 30 roosters were used for the in vitro analysis. Semen was collected twice a week for 2 weeks through dorsal-abdominal massage technique. The evaluation was done hourly until semen quality declined at the 5th-hour. The pooled semen was allotted to seven treatments of semen extenders as undiluted semen, dextrose saline, 10% soursop juice extender, 20% soursop juice extender, 30% soursop juice extender, 40% soursop juice extender, and 50% soursop juice extender for the study. The percentage motility, progressive motility, nonprogressive motility, curvilinear velocity, average path velocity, straight line velocity, linearity, straightness, amplitude of lateral head, beat cross frequency and wobble were analyzed using computer aided sperm analysis. Oxidative status (antioxidant activity and lipid peroxidation) was determined by assay. Result of rooster semen at room temperature and after 1-hour dilution showed that percentage motility, nonprogressive motility, and average path velocity were significantly (P &lt; 0.05) reduced by different soursop juice extenders compared to undiluted semen. After 2-hour dilution of rooster semen, nonprogressive motility, average path velocity, curvilinear velocity, straight line velocity, wobble, liveability and amplitude of lateral head parameters were significantly (P &lt; 0.05) increased by different soursop juice extenders compared to undiluted semen. Antioxidant activity and lipid peroxidation in both room temperature and after 5-hour dilution were affected by different soursop juice extenders in rooster semen. In conclusion, supplementation of soursop juices as an extender to rooster undiluted semen played an improvement role on spermatozoa fertility and oxidative status during processing or preserving ejaculates for insemination.
Exogenous hydrogen sulfide mediates Na+ and K+ fluxes of salt gland in salt-secreting mangrove plant Avicennia marina
Authors: Wei Ming-Yue , Li Huan , Zhang Lu-Dan , Guo Ze-Jun , Liu Ji-Yun , Ding Qian-Su , Zhong You-Hui , Li Jing , Ma Dong-Na , Zheng Hai-Lei 
Published: April 2022

Abstract
Hydrogen sulfide (H2S), is a crucial biological player in plants. Here, we primarily explored the interaction between sodium hydrosulfide (NaHS, a H2S donor) and the fluxes of Na+ and K+ from the salt glands of mangrove species Avicennia marina (Forsk.) Vierh. with non-invasive micro-test technology (NMT) and quantitative real-time PCR (qRT-PCR) approaches under salinity treatments. The results showed that under 400-mM NaCl treatment, the addition of 200-μM NaHS markedly increased the quantity of salt crystals in the adaxial epidermis of A. marina leaves, accompanied by an increase in the K+/Na+ ratio. Meanwhile, the endogenous content of H2S was dramatically elevated in this process. The NMT result revealed that the Na+ efflux was increased from salt glands, whereas K+ efflux was decreased with NaHS application. On the contrary, the effects of NaHS were reversed by H2S scavenger hypotaurine (HT), and DL-propargylglycine (PAG), an inhibitor of cystathionine-γ-lyase (CES, a H2S synthase). Moreover, enzymic assay revealed that NaHS increased the activities of plasma membrane and tonoplast H+-ATPase. qRT-PCR analysis revealed that NaHS significantly increased the genes transcript levels of tonoplast Na+/H+ antiporter (NHX1), plasma membrane Na+/H+ antiporter (SOS1), plasma membrane H+-ATPase (AHA1) and tonoplast H+-ATPase subunit c (VHA-c1), while suppressed above-mentioned gene expressions by the application of HT and PAG. Overall, H2S promotes Na+ secretion from the salt glands of A. marina by up-regulating the plasma membrane and tonoplast Na+/H+ antiporter and H+-ATPase.
The Impact of Health Information Technology for Early Detection of Patient Deterioration on Mortality and Length of Stay in the Hospital Acute Care Setting: Systematic Review and Meta-Analysis
Authors: Herasevich Svetlana , Lipatov Kirill , Pinevich Yuliya , Lindroth Heidi , Tekin Aysun , Herasevich Vitaly , Pickering Brian W. , Barwise Amelia K. 
Published: April 2022

Objective:
To evaluate the impact of health information technology (HIT) for early detection of patient deterioration on patient mortality and length of stay (LOS) in acute care hospital settings.

Data Sources:
We searched MEDLINE and Epub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus from 1990 to January 19, 2021.

Study Selection:
We included studies that enrolled patients hospitalized on the floor, in the ICU, or admitted through the emergency department. Eligible studies compared HIT for early detection of patient deterioration with usual care and reported at least one end point of interest: hospital or ICU LOS or mortality at any time point.

Data Extraction:
Study data were abstracted by two independent reviewers using a standardized data extraction form.

Data Synthesis:
Random-effects meta-analysis was used to pool data. Among the 30 eligible studies, seven were randomized controlled trials (RCTs) and 23 were pre-post studies. Compared with usual care, HIT for early detection of patient deterioration was not associated with a reduction in hospital mortality or LOS in the meta-analyses of RCTs. In the meta-analyses of pre-post studies, HIT interventions demonstrated a significant association with improved hospital mortality for the entire study cohort (odds ratio, 0.78 [95% CI, 0.70–0.87]) and reduced hospital LOS overall.

Conclusions:
HIT for early detection of patient deterioration in acute care settings was not significantly associated with improved mortality or LOS in the meta-analyses of RCTs. In the meta-analyses of pre-post studies, HIT was associated with improved hospital mortality and LOS; however, these results should be interpreted with caution. The differences in patient outcomes between the findings of the RCTs and pre-post studies may be secondary to confounding caused by unmeasured improvements in practice and workflow over time.
Student Ultrasound Interest Group: A Novel Method of Introducing Ultrasound to Physician Assistant Students
Authors: Lolar Sara 
Published: April 2022

Purpose:
This study describes a student ultrasound interest group (SUIG) in a resource-limited physician assistant (PA) program. The benefits of PA student attitudes and knowledge of ultrasound (US) are described.

Methods:
Participation in the SUIG was voluntary. Didactics included free online access medical education (FOAMed) materials. Initial scanning sessions focused on the Focused Assessment with Sonography in Trauma (FAST) exam and were led by a faculty champion with limited US experience. A survey on attitudes and a basic US knowledge test were administered before and after the first session and again 2 months later.

Results:
Thirty-seven students (76% female, mean age 26.4) participated in the initial FAST scanning sessions. All participants agreed that the SUIG session was useful. There was a slight increase in confidence after SUIG sessions (1.27 vs 2.92 on a 5-point scale), and 94% reported increased motivation to seek out ultrasound opportunities on clinical rotations. The average score on the knowledge test increased from 37% to 90% after the scanning sessions; the average score waned over time to 80% after 2 months.

Conclusion:
SUIGs are a valuable way to introduce US to PA students using limited resources. Even minimal exposure can increase PA student confidence and knowledge.
Scoping Review of Mechanical Testing of the Structural and Material Properties of Lower-Limb Prosthetic Sockets
Authors: Baer Gila , Fatone Stefania 
Published: April 2022

ABSTRACT

Introduction
Lower-limb amputations account for most cases seen by certified prosthetists in the United States. Fundamental to the success of a lower-limb prosthesis is the socket, and fundamental to the success of a socket is safety and durability. Currently, there are no standards specific to ensuring the safety and durability of lower-limb prosthetic sockets. The purpose of this scoping review was to describe the mechanical testing procedures used to date to assess the structural and material properties of lower-limb prosthetic sockets, with a view to informing the development of future standards.

Methods
A systematic search was conducted in PubMed, Cumulative Index to Nursing and Allied Health Literature, and Scopus databases and the Canadian Prosthetics & Orthotics Journal website to identify relevant articles. Articles published in English were included if they used mechanical testing to assess the socket and/or socket material and presented those test results.

Results
Fourteen articles were included in this review. They described 30 different mechanical test protocols, consisting of 12 different types of mechanical tests. The most common mechanical tests conducted were tensile, static load, and cyclic load testing. Of the 30 test protocols, 20 referenced current standards that do not include sockets within their scope and modified them in various ways to allow testing of sockets. Of the 14 included articles, 8 described using a mock residual limb during testing, all of which were unique in their composition.

Conclusion
Individual researchers modified existing, nonsocket standards in varying ways to adopt them for use in testing lower-limb prosthetic sockets. This scoping review describes information that may inform the development of socket-specific test protocols.

Clinical Relevance
Future research is needed to determine which tests are good indicators of clinical safety and durability in order to link quantitative results of mechanical testing to the safety and durability of everyday socket use.
The Effect of Single and Multiple Split-Toe Designs on Cross-Slope Adaptability of Prosthetic Feet: A Finite Element Simulation Study
Authors: Maitland Murray E. , Allyn Katheryn J. , Ficanha Evandro M. , Colvin James M. , Wernke Matthew M. 
Published: April 2022

ABSTRACT

Introduction
During activities of daily living, the foot-to-ground contact orientation changes in the frontal plane. The adaptability of a prosthetic foot in the frontal plane may improve functional mobility, comfort, and safety. Current prosthetic feet may or may not have a longitudinal split in the toe portion of the foot. The single-split (two-toe) prosthetic foot has been recommended for adaptability on uneven ground compared with feet without longitudinal splits. The purpose of this study was to evaluate the effect of single and multiple split-toe cantilever spring designs of prosthetic feet on cross-slopes using finite element simulation.

Materials and Methods
Model construction (material data, geometry, and mesh) and simulations were performed using Ansys LS Dyna. A virtual mass of 75 kg, representing body mass, was fixed to the proximal pylon. Foot variations with one to six toes were created by modifying the base geometry with zero to five splits. Walking surfaces that were either flat or a 15-degree cross-slope was virtually fixed in space. The simulation was started at midstance with the pylon in a vertical position and was continued for 0.2 seconds. An initial velocity of 1 m/s was applied to the proximal mass. Lateral deviation, and vertical displacement and mediolateral contact forces of the simulated body mass were calculated. Von Mises stresses, indicating the potential for material failure, were evaluated.

Results
On level ground, after 0.2-second simulation, feet were comparable in outcomes. On a 15-degree cross-slope, lateral deviation of the body mass decreased with increasing splits from 15.5 mm with no splits to 6.9 mm with the five-split variation. Consistent with this finding, maximal and average forces at the pylon-body mass connection also decreased with increasing splits. Von Mises stress values increased at the proximal toes with increasing splits consistent with narrowing of each toe.

Discussion and Conclusions
The current study showed that the benefit of increasing the number of toes was most significant with the first split and diminishing returns as the number of splits increased beyond three. Adaptability of split-toe variations may have benefits beyond cross-slopes because there are many instances during activities of daily living where the foot-to-ground angle may change. These findings should be tested using other research methods such as biomechanical studies of multiple split-toe prosthetic feet, and if these results are supported, clinical trials may be warranted.

Clinical Relevance
This study supports the use of split-toe prosthetic feet for people who want more frontal plane adaptability during gait or who have lateral pressures at the socket. The study predicts that prosthetic feet with more than one split could provide more adaptability and should be explored for clients.
Effect of Time Outdoors and Near-viewing Time on Myopia Progression in 9- to 11-year-old Children in Chongqing
Authors: Fan Yujie , Liao Juan , Liu Shichun , Cai Xueqin , Lv Sha , Yang Qiao , Dong Yaoxi , Li Hua , Song Shengfang 
Published: April 2022

SIGNIFICANCE
We used an Akeso device to record the visual behavior of children with myopia in two learning modes. We found that online class mode may increase near-viewing time and reduce outdoor time compared with the traditional school mode and may be responsible for accelerating myopia progression.

PURPOSE
We aimed to explore the effects of visual behavior in different learning modes on myopia progression among children 9 to 11 years old.

METHODS
Forty-nine children were included and requested to use a wearable device to objectively record visual behavior in real time from November 2019 to November 2020; participants took online classes from mid-February to early May 2020 during this period. Data (including glasses-wearing time, outdoor time, and near-viewing time) were collected during two 14-day periods, which included the online class learning mode (March 2 to 15, 2020) and the traditional school mode (May 20 to June 2, 2020). Spherical equivalent refraction and axial length were obtained at baseline, at 6-month intervals, and 1 year later.

RESULTS
Outdoor time during online class mode (median, 9.5 minutes; interquartile range, 0.75 to 48 minutes) was significantly lower than during the school mode (median, 29 minutes; interquartile range, 11.50 to 50 minutes; P < .001). The mean ± standard deviation of near-viewing time was significantly different between online class mode (396.58 ± 114.41 minutes) and school mode (376.52 ± 93.99 minutes; P = .007, F = 19.56). In comparison with the baseline examination (−2.33 ± 0.81 D), mean spherical equivalent refraction in oculus dexter corresponding to the 6-month examination was decreased (−2.94 ± 0.83 D, P = .001), indicating a significant increase in myopia during online class mode.

CONCLUSIONS
This study provides evidence of the association of learning mode and myopia progression. Accelerated progression of myopia in online class mode may be related to increased near-viewing time and decreased time spent in outdoor activities.
Surface Electromyography of the Trapezius and Sternocleidomastoid during Computer Work with Presbyopic Corrections
Authors: Kolbe Oliver , Bitterlich Kathrin , Lahne Johanna , Degle Stephan , Anders Christoph 
Published: April 2022

SIGNIFICANCE
During computer work in controlled laboratory conditions, wearing multifocal contact lenses (MFCLs) showed no lower muscle load but increased subjective perception of comfort with equivalent visual quality and comparable tolerance.

PURPOSE
Because musculoskeletal complaints are frequent among computer workers, this study used the muscle electrophysiological activity of shoulder and neck muscles in presbyopic computer workers who received either progressive addition lenses for general purpose (GP-PALs) or MFCLs.

METHODS
For this crossover study, 11 presbyopic computer workers aged 55 ± 4 years (mean ± standard deviation) were equipped with GP-PALs and MFCLs in a randomized order. Surface electromyography signals were recorded bilaterally from shoulder and neck muscles during short-term computer work tasks using an optimally adjusted visual display unit workplace. The amplitude probability distribution function, the number and total duration of EMG gaps, and sustained low-level muscle activity periods of the surface electromyography signals were calculated. Comfort and correction type preferences were assessed. Head inclination was objectively evaluated.

RESULTS
Multifocal contact lenses elicited no significant lower muscle load than GP-PALs. The number of sustained low-level muscle activity periods longer than 60 seconds was similar between visual aids. The total amount of gaps was significantly higher with MFCLs (44 gaps) compared with progressive addition lenses for general purpose (15 gaps) in all analyzed periods for all participants. However, there were no significant differences for the median in the intraindividual comparisons (P = .22, dz = 0.52). Multifocal contact lenses scored statistically significant higher in comfort values with equivalent visual quality and comparable tolerance (P = .003, dz
= 1.51).

CONCLUSIONS
Although the study failed to show clear results, wearing MFCLs seems to enhance working comfort compared with GP-PALs subjectively.