bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sign and Spoken Language Processing Differences in the Brain: A Brief Review of Recent Research
Authors: Caldwell Hayley Bree 
Published: February 2022

Background: It is currently accepted that sign languages and spoken languages have significant processing commonalities. The evidence supporting this often merely investigates frontotemporal pathways, perisylvian language areas, hemispheric lateralization, and event-related potentials in typical settings. However, recent evidence has explored beyond this and uncovered numerous modality-dependent processing differences between sign languages and spoken languages by accounting for confounds that previously invalidated processing comparisons and by delving into the specific conditions in which they arise. However, these processing differences are often shallowly dismissed as unspecific to language. Summary: This review examined recent neuroscientific evidence for processing differences between sign and spoken language modalities and the arguments against these differences’ importance. Key distinctions exist in the topography of the left anterior negativity (LAN) and with modulations of event-related potential (ERP) components like the N400. There is also differential activation of typical spoken language processing areas, such as the conditional role of the temporal areas in sign language (SL) processing. Importantly, sign language processing uniquely recruits parietal areas for processing phonology and syntax and requires the mapping of spatial information to internal representations. Additionally, modality-specific feedback mechanisms distinctively involve proprioceptive post-output monitoring in sign languages, contrary to spoken languages’ auditory and visual feedback mechanisms. The only study to find ERP differences post-production revealed earlier lexical access in sign than spoken languages. Themes of temporality, the validity of an analogous anatomical mechanisms viewpoint, and the comprehensiveness of current language models were also discussed to suggest improvements for future research. Key message: Current neuroscience evidence suggests various ways in which processing differs between sign and spoken language modalities that extend beyond simple differences between languages. Consideration and further exploration of these differences will be integral in developing a more comprehensive view of language in the brain.
Voclosporin: A Novel Calcineurin Inhibitor for the Treatment of Lupus Nephritis
Authors: McArn Ann C. , Nixon Alexander R. , Jarrell Katherine L. 
Published: February 2022

Objective: To describe the safety, efficacy, and potential role in therapy of voclosporin, an oral calcineurin inhibitor approved by the Food and Drug Administration (FDA) in January 2021 as an adjunct treatment for lupus nephritis. Data Sources: A literature search was conducted using PubMed with the following terms: voclosporin, Lupkynis, and lupus nephritis (January 1, 2010, to December 1, 2021). FDA product labeling was also reviewed for pertinent data sources. Study Selection and Data Extraction: All articles were considered for inclusion. English-language articles selected included preclinical and clinical studies examining the pharmacokinetics, efficacy, and/or safety of voclosporin. Data Synthesis: Voclosporin has been studied as an adjunct immunosuppressive agent in patients with lupus nephritis. Drug design allows for a more predictable pharmacokinetic profile than other calcineurin inhibitors. Data suggest that adding this newly approved calcineurin inhibitor to a regimen of mycophenolate mofetil and corticosteroids produces promising therapeutic results. As such, voclosporin has been approved for use in patients with active lupus nephritis who are maintained on immunosuppressive therapy with mycophenolate mofetil and a corticosteroid. Relevance to Patient Care and Clinical Practice: Voclosporin may be a favorable calcineurin inhibitor in patients with lupus nephritis, due to a predictable pharmacokinetic profile. This allows for decreased therapeutic drug monitoring and suggests a favorable adverse effect profile. However, cost remains a consideration with this new agent. Conclusions: Current available data suggest that voclosporin is a promising adjunct treatment option for patients with active lupus nephritis who are maintained on mycophenolate mofetil and a corticosteroid.
Economic Impact of Ambulatory Clinical Pharmacists in an Advanced Heart Failure Clinic
Authors: Kido Kazuhiko , Colvin Bailey M. , Broscious Rachael , Bongiorni Sydney , Sokos George , Kamal Khalid M. 
Published: February 2022

Background: Clinical pharmacists play pivotal roles in multidisciplinary heart failure (HF) teams through the management of HF pharmacotherapy, but no study has examined the economic impact of HF ambulatory clinical pharmacists in an advanced HF clinic. Objective: The objective of the study was to evaluate the economic impact of HF ambulatory clinical pharmacist interventions in an advanced HF clinic using a cost-benefit analysis. Methods: This prospective observational study detailed HF ambulatory clinical pharmacist interventions over 6 months in an advanced HF clinic in a single-center tertiary teaching hospital. The economic impact of the interventions was estimated based on the indirect cost savings with pharmacist interventions and direct cost savings recommendations. A cost-benefit analysis was performed to assess the cost of delivering the interventions compared with the benefits generated by clinical pharmacists. Results were reported as a benefit-cost ratio and net benefits. Results: HF ambulatory clinical pharmacists made a total of 2,361 provider-accepted interventions over 6 months. Overall, the 3 most common intervention types were medication reconciliation (28.7%), dose change (20.8%), and addition of medication (12.3%). Anticoagulation (21.2%) was the most common intervened class of medication, followed by sodium-glucose cotransporter-2 inhibitor (12.3%) and angiotensin receptor neprilysin inhibitor (9.2%). The total net benefits were $55,553.24 over 6 months and the benefit-cost ratio was 1.55. Conclusion and Relevance: The addition of cardiology clinical pharmacists to an advanced HF clinic may be financially justified and cost-beneficial.
Long-term blood metal ion levels and clinical outcome after Birmingham hip arthroplasty
Authors: Pietiläinen Sakari , Lindström Miro , Laaksonen Inari , Venäläinen Mikko S. , Lankinen Petteri , Mäkelä Keijo T. 
Published: February 2022

Background and objective: Our aim was to assess long-term metal ion level changes and clinical outcome in patients with a Birmingham hip arthroplasty. Methods: For the purpose of this study, we identified all BHR hip resurfacing arthroplasty (HRA) and total hip arthroplasty (THA) operations performed in Turku University Hospital. A random coefficient model was used to compare the change between the first and last metal ion measurement. A Kaplan–Meier estimator was used to assess the survivorship of the BHR HRA and BHR THA with metal related adverse events (pseudotumor, elevated metal ions above the safe upper limit, revision due to metallosis), or revision due to any reason as endpoints with 95% confidence intervals (CIs). Results: BHR HRA was used in 274 hips (233 patients). In addition, we identified 38 BHR-Synergy THAs (38 patients). Operations were performed between 2003 and 2010. Median follow-up time was 14 years for BHR HRA (range: 0.6–17) and 11 years for BHR THA (range: 4.7–13). In the BHR HRA group, geometric means of Cr and Co levels decreased from 2.1 to 1.6 ppb and 2.4 to 1.5 ppb, respectively, during a 3.0-year measurement interval. Metal ion levels in the BHR THA group did not show notable increase. The survivorship of BHR HRA was 66% in 16 years and 34% for BHR THA at 12 years for any metal-related adverse event. Conclusions: Patients with a Birmingham hip device do not seem to benefit from frequent repeated metal ion measurements. The amount of patients with metal-related adverse events was relatively high, but many of them did not require surgery.
Biopsy Forceps-Assisted Loop Snare Technique for Complex Retrieval of Inferior Vena Cava Filter
Authors: Yao Sicheng , Li Yangyang , Zhu Feng , Guan Sheng , Ge Xiaohu , Ci Hongbo 
Published: February 2022

Severe tilt with embedded hooks is a common obstacle to successful inferior vena cava (IVC) filter retrieval. We present a case for which the biopsy forceps-assisted loop snare technique was successfully used to retrieve filters with hooks embedded in the IVC wall for which conventional retrieval failed. The technique is effective and provides a less-invasive, low-cost method for the complex retrieval of IVC filters. Introduction: Severe tilt with embedded hooks is a common obstacle to successful inferior vena cava (IVC) filter retrieval. Methods: Disposal biopsy forceps were used to remodel the filter hook in the center position to release the embedded hook from the caval wall. Results: The biopsy forceps-assisted loop snare technique was successfully used to retrieve filters with hooks embedded in the IVC wall. Conclusion: The biopsy forceps-assisted loop snare technique we present here offers a new solution for the complex retrieval of IVC filters. This technique may prove useful in cases where standard techniques at filter retrieval fail.
Contributions of Social Research Methodologies to Social Change: Giving Voice to the Voiceless
Authors: Tawodzera Mazvita Cecilia , Mabasa Layane Thomas , Themane Mahlapahlapana 
Published: February 2022

Historically, social research methodologies have been construed as being less significant in their contribution to social change. This perception emanates from those who view social research methodologies as an accessory to the natural sciences. Contrary to this view, this article, on the schooling experiences of children who have been left behind by their parents in Zimbabwe, is used to contribute to the debate. It seeks to present our experiences in the application of social research methodologies, including challenges and their contribution to social change. However, this change remains a contested issue in research because there is no consensus on how to measure it. The study followed a qualitative research approach, using an interpretive phenomenological study design. A purposive sampling strategy was used to select 12 secondary school children (12–18 years old). Data were constructed through two methods, interviews and document analysis. The overall finding of the study revealed that social sciences methodologies can make a contribution to social change. This was illustrated by the fact that when social methodological approaches were used, children were enabled to confidently express their lived experiences by creating a child-friendly environment such as child-centeredness, democratic participation and inclusivity. Consequently, the findings have shed some light on the way in which policy makers should develop policies with regard to left-behind children (LBC). On the basis of these findings, the article argues that social research methodologies can make a difference in social change, despite challenges that may emerge. The findings may have implications for social researchers and for our study. For example, the findings could minimise hermeneutics injustice by mediating what the marginalised groups, such as children, may express despite scepticism about their authenticity which is important for social change.
Abnormal uterine bleeding and associated factors among reproductive age women in Jimma town, Oromia Region, Southwest Ethiopia
Authors: Gerema Urge , Kene Kumsa , Abera Deriba , Adugna Tesfaye , Nigussie Mebrat , Dereje Diriba , Mulugeta Temesgen 
Published: February 2022

Introduction: Abnormal uterine bleeding is any bleeding that deviates from normal menstruations. It differs in terms of frequency of bleeding, duration, and the pattern of bleeding during menstrual cycle or menopause. It is a major gynecological problem for medical visits among women in the reproductive aged group. However, data on abnormal uterine bleeding in Ethiopia are limited. Therefore, this study aimed to assess the abnormal uterine bleeding and associated factors among reproductive age women in Jimma town, Southwest Ethiopia. Methods: Community-based cross-sectional study was employed from 1 January to 30 April 2020. Six hundred sixty women were selected by using systematic random sampling. Data were collected by using semi-structured questionnaires. Data were entered into EPI data version 3.1 and analyzed by using SPSS version 25 software. All predictor’s variables with p value <0.25 in bivariable analysis were entered into multivariable logistic regression analysis. Variables with a p value of less than 0.05 in the multivariable analysis were taken as statistically significant predictors of abnormal uterine bleeding. Results: Out of 660 participants, 225 (34.1%) had abnormal uterine bleeding. From women with abnormal uterine bleeding, the prevalence of metrorrhagia, heavy periods, oligomenorrhea, inter-menstrual bleeding, polymenorrhea, and amenorrhea was 59 (26.2%), 54 (24%), 53 (23.5%), 46 (20.4%), 35 (15.5%), and 25 (11.1%), respectively. History of abortion (adjusted odds ratio = 1.5, 95% confidence interval: 1.02–2.41), history of uterine fibroids (adjusted odds ratio = 3.83, 95% confidence interval: 1.85–7.94), history of sexually transmitted infection (adjusted odds ratio = 2.2, 95% confidence interval: 1.33–3.66), and the history of intrauterine device (adjusted odds ratio = 2.1, 95% confidence interval: 1.39–2.97) were significantly associated with abnormal uterine bleeding. Conclusion: The prevalence of abnormal uterine bleeding was higher in Jimma town.
Time for themselves: Perceptions of physical activity among first and second-generation Pakistani women living in the Raval, Barcelona
Authors: Lansburgh Flora , Jacques-Aviñó Constanza , Pons-Vigués Mariona , Morgan Rosemary , Berenguera Anna 
Published: February 2022

Objectives: Pakistani women experience higher-than-average rates of certain chronic diseases, including diseases related to sedentary lifestyles. The aim of this study is to explore how first and second-generation Pakistani women living in the Raval, Barcelona, conceive of physical activity, and their barriers and facilitators around participating in physical activity, with the goal of increasing physical activity in this group. Methods: Qualitative research with an intersectional approach. Nine informal interviews with key community informants were conducted from November 2018 to January 2019 to gain background on the topic, using snowball sampling. Eleven individual interviews were conducted from February to June 2019. Seven were with Pakistani women having lived, or currently living, in the neighborhood of the Raval, Barcelona. Four additional interviews were conducted with non-Pakistani women key community informants who have worked extensively with this community. Thematic content analysis was carried out using ATLAS.ti. Results: First-generation Pakistani women generally did not have physical activity present in their daily lives, but by most accounts wished to. Areas that shed light on this included the following: limited economic opportunities and associated living conditions, barriers to social integration, health concepts and access to information, and cultural norms and related gender roles. For the first-generation, gender-related divisions of labor as well as the absence of the concept of self-care were particularly relevant barriers to their participation in physical activity. The experience of immigration-related grief emerged as a transversal theme which overlapped with multiple areas. While both generations expressed a need for the separation of genders during physical activity—as per their cultural interpretation of Islam—the lack of such spaces was highlighted as a principal barrier in physical activity among the second generation. Conclusion: These findings shed light on distinct elements that exert influence in Pakistani women immigrants’ participation in physical activity—among them: social and living conditions, access to public space, and gender-related work distribution and cultural norms—which are in turn influenced by first or second-generation immigration status. Considering the specific needs of both groups when proposing politics and health programs to encourage physical activity is paramount in order to successfully partner with these populations.
Prevalence of dysmenorrhea and associated factors among students in Ethiopia: A systematic review and meta-analysis
Authors: Molla Alemayehu , Duko Bereket , Girma Bekahegn , Madoro Derebe , Nigussie Jemberu , Belayneh Zelalem , Mengistu Nebiyu , Mekuriaw Birhanie 
Published: February 2022

Background: Dysmenorrhea is one of the most common gynecological complaints among adolescent women. It has been associated with short-term absenteeism in school and has a negative impact on academic and daily activities. Therefore, the aim of the study was to show the evidence on the magnitude and correlates of dysmenorrhea in Ethiopia. Method: In this systematic review and meta-analysis, we searched the literature from different databases such as PubMed/Medline, Science Direct, PsycINFO, and Cochrane library. We also used unpublished literature from Google, Google Scholar. The quality of the included articles was assessed using the Newcastle-Ottawa Scale. Data were extracted using a Microsoft Excel data extraction format. STATA version 14 statistical software was used for data analysis. To assess the heterogeneity of the primary articles, the Cochrane Q test statistics and the I2 test were carried out. Publication bias was inspected by funnel plot, and Egger’s test was performed to confirm the presence of publication bias. A random-effects meta-analysis was used to estimate the pooled prevalence of dysmenorrhea and its associated factors. Result: A total of 12 studies were included in the final meta-analysis. The pooled prevalence estimate of dysmenorrhea among female students in Ethiopia is 71.69% (66.82%–76.56%). In our systematic review, among factors associated with dysmenorrhea, the family history of dysmenorrhea was frequently reported in included studies. Therefore, dysmenorrhea was significantly associated with a family history of dysmenorrhea (adjusted odds ratio = 4.69 (95% confidence interval: 2.80–7.85)). Conclusion: The pooled prevalence estimate of dysmenorrhea among students was much higher in Ethiopia. Health professionals and teachers should educate and support students to follow their menstrual cycle regularly in the event of irregular periods. There should be an awareness of the negative consequences of dysmenorrhea to reduce the physical and psychological stresses that affect women and their families.
Impact of Canadian human immunodeficiency virus non-disclosure case law on experiences of violence from sexual partners among women living with human immunodeficiency virus in Canada: Implications for sexual rights
Authors: Patterson Sophie , Nicholson Valerie , Gormley Rebecca , Carter Allison , Logie Carmen H , Closson Kalysha , Ding Erin , Trigg Jason , Li Jenny , Hogg Robert , de Pokomandy Alexandra , Loutfy Mona , Kaida Angela 
Published: February 2022

Objectives: People living with human immunodeficiency virus in Canada can face criminal charges for human immunodeficiency virus non-disclosure before sex, unless a condom is used and their viral load is <1500 copies/mL. We measured the reported impact of human immunodeficiency virus non-disclosure case law on violence from sexual partners among women living with human immunodeficiency virus in Canada. Methods: We used cross-sectional survey data from wave 3 participant visits (2017–2018) within Canadian HIV Women’s Sexual and Reproductive Health Cohort Study; a longitudinal, community-based cohort of women living with human immunodeficiency virus in British Columbia, Ontario and Quebec. Our primary outcome was derived from response to the statement: ‘[HIV non-disclosure case law has] increased my experiences of verbal/physical/sexual violence from sexual partners’. Participants responding ‘strongly agree/agree’ were deemed to have experienced increased violence due to the law. Participants responding ‘not applicable’ (i.e. those without sexual partners) were excluded. Multivariate logistic regression identified factors independently associated with increased violence from sexual partners due to human immunodeficiency virus non-disclosure case law. Results: We included 619/937 wave 3 participants. Median age was 46 (interquartile range: 39–53) and 86% had experienced verbal/physical/sexual violence in adulthood. Due to concerns about human immunodeficiency virus non-disclosure case law, 37% had chosen not to have sex with a new partner, and 20% had disclosed their human immunodeficiency virus status to sexual partners before a witness. A total of 21% self-reported that human immunodeficiency virus non-disclosure case law had increased their experiences of verbal/physical/sexual violence from sexual partners. In adjusted analyses, women reporting non-White ethnicity (Indigenous; African/Caribbean/Black; Other), unstable housing and high human immunodeficiency virus–related stigma had significantly higher odds of reporting increased violence from sexual partners due to human immunodeficiency virus non-disclosure case law. Conclusion: Findings bolster concerns that human immunodeficiency virus criminalization is a structural driver of intimate partner violence, compromising sexual rights of women living with human immunodeficiency virus. Human immunodeficiency virus non-disclosure case law intersects with other oppressions to regulate women’s sexual lives.
Hypnotherapy for irritable bowel syndrome: patient expectations and perceptions
Authors: Donnet Anne-Sophie , Hasan Syed Shariq , Whorwell Peter J. 
Published: February 2022

Introduction: Numerous studies have shown that hypnotherapy (HT) is effective in irritable bowel syndrome (IBS) using traditional symptom severity end points. However, there is now interest in capturing the patient’s perception of their illness and treatment because what patients expect from their treatment may differ from that of their healthcare provider. Objective: To record patient perceptions and expectations of hypnotherapy as well as their symptom response. Methods: 150 consecutive IBS patients (116 females, 34 males, aged 16–81 years) receiving hypnotherapy completed questionnaires recording IBS symptom severity, quality of life, noncolonic symptoms, anxiety and depression levels before and after treatment. Their expectations and perceptions of HT were also recorded, including a free text reflection. Results: 121 patients (81%) responded to treatment consistent with our previous experience. Symptom severity scores, noncolonic symptoms, quality of life, anxiety and depression significantly all improved after HT ( p < 0.001). Expectancy of an improvement with hypnotherapy was greater in those who did not respond to treatment (63%) than those who did (57%, p < 0.001). Scepticism and apprehension were common before treatment and replaced with enthusiasm afterwards. Free text responses after treatment were overwhelmingly positive. Patients also reported a variety of other benefits and even 20 of 29 symptom nonresponders (70%) still considered treatment worthwhile. Conclusion: Although initially perceived negatively, hypnotherapy improved symptoms and resulted in a wide range of additional benefits. Expectation did not necessarily influence outcome. Recording IBS symptoms alone does not fully capture the patient’s experience of treatment and needs to be considered in future research.