bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perspectives Regarding Medications for Opioid Use Disorder Among Individuals with Mental Illness
Authors: Tarn Derjung M. , Shih Kevin J. , Ober Allison J. , Hunter Sarah B. , Watkins Katherine E. , Martinez Jeremy , Montero Alanna , McCreary Michael , Leamon Isabel , Sheehe John , Bromley Elizabeth 
Published: July 2022

AbstractMost people with co-occurring opioid use disorder (OUD) and mental illness do not receive effective medications for treating OUD. To investigate perspectives of adults in a publicly-funded mental health system regarding medications for OUD (MOUD), we conducted semi-structured telephone interviews with 13 adults with OUD (current or previous diagnosis) receiving mental health treatment. Themes that emerged included: perceiving or using MOUDs as a substitute for opioids or a temporary solution to prevent withdrawal symptoms; negative perceptions about methadone/methadone clinics; and viewing MOUD use as “cheating”. Readiness to quit was important for patients to consider MOUDs. All participants were receptive to discussing MOUDs with their mental health providers and welcomed the convenience of receiving care for their mental health and OUD at the same location. In conclusion, clients at publicly-funded mental health clinics support MOUD treatment, signaling a need to expand access and build awareness of MOUDs in these settings.
How Retirement Affects Mental Health, Cognitive Skills and Mortality; An Overview of Recent Empirical Evidence
Authors: van Ours Jan C. 
Published: July 2022

AbstractRetiring is an individual labor market transition that affects the personal life of the workers involved and sometimes the life of their partners. This paper presents an overview of recent studies on the effects of retirement on mental health, cognitive ability and mortality. The results are all over the place but on average it seems like at retirement mental health improves, cognitive skills deteriorate and mortality is not affected. However, there is substantial effect heterogeneity. The range of outcomes is partly related to heterogeneity in terms of personal characteristics, type of job, institutional arrangements, and whether retiring was voluntary or mandatory. The variation in empirical findings makes it hard to see the forest for the trees and advocate evidence-based retirement policies that take health effects into account. Nevertheless, introducing more individual flexibility in the timing of retirement is a worthwhile policy alternative since this seems to be unambiguously beneficial for the health of workers retiring.
Cardinal Composition
Authors: Vogt Lisa , Werner Jonas 
Published: July 2022

AbstractThe thesis of Weak Unrestricted Composition says that every pair of objects has a fusion. This thesis has been argued by Contessa (Analysis 72(3):455–457, 2012) and Smith (Erkenntnis 84(1):41–55, 2019) to be compatible with the world being junky and hence to evade an argument against the necessity of Strong Unrestricted Composition proposed by Bohn (Analysis 69(1):27–31, 2009a, Philos Q 59(235):193–201, 2009b). However, neither Weak Unrestricted Composition alone nor the different variants of it that have been proposed in the literature can provide us with a satisfying answer to the special composition question, or so we will argue. We will then go on to explore an alternative family of purely mereological rules in the vicinity of Weak Unrestricted Composition, Cardinal Composition: A plurality of pairwise non-overlapping objects composes an object iff the objects in the plurality are of cardinality smaller than $$\kappa $$
κ
. As we will show, all the instances for infinite $$\kappa $$
κ
s determine fusion and are compatible with junk, and every instance for a $$\kappa > \aleph _0$$

κ
>

ℵ
0

is furthermore compatible with gunk and dense chains of parthood.
Democratic citizenship and polarization: Robert Talisse’s theory of democracy
Authors: Sharp Daniel 
Published: July 2022

AbstractThis review essay critically discusses Robert Talisse’s account of democracy and polarization. I argue that Talisse overstates the degree to which polarization arises from the good-faith practice of democratic citizenship and downplays the extent to which polarization is caused by elites and exacerbated by social structures; this leads Talisse to overlook structural approaches to managing polarization and leaves his account of how citizens should respond to polarization incomplete. I conclude that Talisse’s insights should nevertheless be integrated into a broader agenda for thinking about the causes and solutions to polarization.
Development, methodology, and adaptation of the Medicare Consumer Assessment of Healthcare Providers and Systems (CAHPS®) patient experience survey, 2007–2019
Authors: Orr Nate , Zaslavsky Alan M. , Hays Ron D. , Cleary Paul D. , Haviland Amelia M. , Brown Julie A. , Dembosky Jacob W. , Martino Steven C. , Gaillot Sarah , Elliott Marc N. 
Published: July 2022

AbstractThe Medicare Consumer Assessment of Healthcare Providers and Systems (CAHPS®) surveys collect standardized information about patient experiences of care from nationally representative samples of people with Medicare to support consumers’ enrollment choices and enable the Centers for Medicare & Medicaid Services to monitor care quality and incentivize high quality patient-centered care. Since 2007, protocols for data collection, analysis, and reporting have evolved to address expanded Medicare coverage options and a shift from a single survey vendor to a model in which health plans hire approved vendors to administer the survey. During that time, response rates for all types of surveys have declined; increasing effort has gone toward increasing survey participation, especially among people whose preferred language is not English. In this paper, we describe the history, goals, and current use of the Medicare CAHPS surveys. We also summarize key methodological issues, such as sample design, field implementation and data cleaning, adjustment, scoring, and report production. Additionally, we discuss issues that may arise more generally in managing a large, annual national survey that has direct impact on policy, and consider how a long-running survey of this nature may need to evolve to reflect changes in health care delivery and promote standardization in survey administration while maintaining survey content.
Factor associated with the occurrence of epilepsy in autism: a systematic review
Authors: Zarakoviti Eleni , Shafran Roz , Skuse David , McTague Amy , Batura Neha , Palmer Tom , Dalrymple Emma , Bennett Sophie D. , Reilly Colin 
Published: July 2022

AbstractThis systematic review aimed to identify factors significantly associated with the occurrence of epilepsy in autistic individuals and to consider the impact of study quality on findings. Electronic databases were systematically searched on October 2nd, 2020 and records retrieved were limited to those published from 2000 onwards. Study quality was categorised as ‘good’, ‘moderate’ or ‘weak’. Fifty-three studies were included and in studies where the prevalence of epilepsy was reported (n = 257,892), 18,254 (7%) had co-occurring epilepsy. Intellectual disability/cognitive impairment was the most commonly reported risk factor associated with occurrence of epilepsy in autistic individuals. The evidence supporting other, potentially relevant factors was weak and inconsistent and requires further evaluation. Only 9/53 studies were considered ‘good’ quality.
Compressing multireference character of wave functions via fermionic mode optimization
Authors: Máté Mihály , Petrov Klára , Szalay Szilárd , Legeza Örs 
Published: July 2022

AbstractIn this work, we present a brief overview of the fermionic mode optimization within the framework of tensor network state methods (Krumnow et al. in Phys Rev Lett 117:210402, 2016, https://doi.org/10.1103/PhysRevLett.117.210402), and demonstrate that it has the potential to compress the multireference character of the wave functions after finding optimal molecular orbitals (modes), based on entanglement minimization. Numerical simulations have been performed for the nitrogen dimer in the cc-pVDZ basis for the equilibrium and for stretched geometries.
Sex Differentially Alters Secretion of Brain Extracellular Vesicles During Aging: A Potential Mechanism for Maintaining Brain Homeostasis
Authors: Kim Yohan , Pérez-González Rocío , Miller Chelsea , Kurz Michelle , D’Acunzo Pasquale , Goulbourne Chris N. , Levy Efrat 
Published: July 2022

AbstractExtracellular vesicles (EVs) in the brain play a role in neuronal homeostasis by removing intracellular material and regulating cell-to-cell communication. Given that sex and aging differentially modulate brain networks, we investigated sex-dependent differences in EV levels and content in the brain during aging. EVs were isolated from the brains of 3, 6, 12, 18, and 24 month-old female and male C57BL/6 J mice, and the levels of different EV species determined. While the number of plasma membrane-derived microvesicles and a subset of late endosomes-derived exosomes increased with age in the brain of female mice, no significant changes were seen in males. Mitochondria-derived mitovesicles in the brain increased during aging in both sexes, a change that may reflect aging-dependent alterations in mitochondrial function. These findings reveal enhanced turnover during aging in female brains, suggesting a mechanism for advantageous successful female brain aging and sex-depending different susceptibility to age-related neurodegenerative diseases.
The crucial role of blue light as a driver of litter photodegradation in terrestrial ecosystems
Authors: Wang Qing-Wei , Pieristè Marta , Kotilainen Titta K. , Forey Estelle , Chauvat Matthieu , Kurokawa Hiroko , Robson T. Matthew , Jones Alan G. 
Published: July 2022

Abstract

Background and aim
Wherever sunlight reaches litter, there is potential for photodegradation to contribute to decomposition. Although recent studies have weighed the contribution of short wavelength visible and ultraviolet (UV) radiation as drivers of photodegradation, the relative importance of each spectral region across biomes and plant communities remains uncertain.

Methods
We performed a systematic meta-analysis of studies that assessed photodegradation through spectrally selective attenuation of solar radiation, by synthesizing 30 published studies using field incubations of leaf litter from 110 plant species under ambient sunlight.

Results
Globally, the full spectrum of sunlight significantly increased litter mass loss by 15.3% ± 1% across all studies compared to darkness. Blue light alone was responsible for most of this increase in mass loss (13.8% ± 1%), whereas neither UV radiation nor its individual constituents UV-B and UV-A radiation had significant effects at the global scale, being only important in specific environments. These waveband-dependent effects were modulated by climate and ecosystem type. Among initial litter traits, carbon content, lignin content, lignin to nitrogen ratio and SLA positively correlated with the rate of photodegradation. Global coverage of biomes and spectral regions was uneven across the meta-analysis potentially biasing the results, but also indicating where research in lacking.

Conclusions
Across studies attenuating spectral regions of sunlight, our meta-analysis confirms that photodegradation is a significant driver of decomposition, but this effect is highly dependent on the spectral region considered. Blue light was the predominant driver of photodegradation across biomes rather than UV radiation.
The ExoMars Schiaparelli Entry, Descent and Landing Demonstrator Module (EDM) System Design
Authors: Ball Andrew J. , Blancquaert Thierry , Bayle Olivier , Lorenzoni Leila V. , Haldemann Albert F. C. ,   the Schiaparelli EDM team
Published: July 2022

AbstractThe Entry, Descent and Landing Demonstrator Module (EDM) named Schiaparelli, was the ESA-led Mars lander element of the ESA-Roscosmos ExoMars 2016 mission. Following launch on 14 March 2016 with the ExoMars Trace Gas Orbiter (TGO) and cruise to Mars, Schiaparelli separated for encounter with Mars to demonstrate entry, descent and landing technologies. Although on 19 October 2016 the final touchdown and surface operation were not achieved, other aspects were demonstrated and reported via real-time telemetry transmitted at 8 kbps in UHF during entry and descent.This paper presents a technical description of the elements of the Schiaparelli EDM system and its operation, plus reference to published post-flight analyses of the data obtained.
An ambient denoising method based on multi-channel non-negative matrix factorization for wheezing detection
Authors: Muñoz-Montoro Antonio J. , Revuelta-Sanz Pablo , Martínez-Muñoz Damian , Torre-Cruz Juan , Ranilla José 
Published: July 2022

AbstractIn this paper, a parallel computing method is proposed to perform the background denoising and wheezing detection from a multi-channel recording captured during the auscultation process. The proposed system is based on a non-negative matrix factorization (NMF) approach and a detection strategy. Moreover, the initialization of the proposed model is based on singular value decomposition to avoid dependence on the initial values of the NMF parameters. Additionally, novel update rules to simultaneously address the multichannel denoising while preserving an orthogonal constraint to maximize source separation have been designed. The proposed system has been evaluated for the task of wheezing detection showing a significant improvement over state-of-the-art algorithms when noisy sound sources are present. Moreover, parallel and high-performance techniques have been used to speedup the execution of the proposed system, showing that it is possible to achieve fast execution times, which enables its implementation in real-world scenarios.
Imaging the Alternatively Spliced D Domain of Tenascin C in a Preclinical Model of Inflammatory Bowel Disease
Authors: Zhang Liang , Wang Yuzhen , Homan Kristoff T. , Gaudette Stephanie M. , McCluskey Andrew J. , Chan Ying , Murphy Joanne , Abdalla Mary , Nelson Christine M. , Sun Victor Z. , Erickson Jamie E. , Knight Heather L. , Clabbers Anca , Sterman Annette J. Schwartz , Mitra Soumya 
Published: July 2022

Abstract
Purpose
To image colon-expressed alternatively spliced D domain of tenascin C in preclinical colitis models using near infrared (NIR)-labeled targeted molecular imaging agents.
Procedures.
A human IgG1 with nanomolar binding affinity specific to the alternatively spliced D domain of tenascin C was generated. Immunohistochemistry identified disease-specific expression of this extracellular matrix protein in the colon of mice given dextran sulfate sodium in the drinking water. The antibody reagent was labeled with the NIR fluorophore IRDye 800CW via amine chemistry and intravenously dosed to evaluate in vivo targeting specificity. Increasing doses of imaging agent were given to estimate the saturating dose.

Results
The NIR-labeled proteins successfully targeted colonic lesions in a murine model of colitis. Co-administration of a molar excess competing unlabeled dose reduced normalized uptake in diseased colon by > 70%. Near infrared ex vivo images of colon resected from diseased animals showed saturation at doses exceeding 1 nmol and was confirmed with additional quantitative ex vivo biodistribution. Cellular-level specificity and protein stability were assessed via microscopy.

Conclusions
Our imaging data suggest the alternatively spliced D domain of tenascin C is a promising target for delivery-based applications in inflammatory bowel diseases.
Changes in the liver proteome in apoE knockout mice exposed to inhalation of silica nanoparticles indicate mitochondrial damage and impairment of ER stress responses associated with microvesicular steatosis
Authors: Stachyra Kamila , Kiepura Anna , Suski Maciej , Ulatowska-Białas Magdalena , Kuś Katarzyna , Wiśniewska Anna , Czepiel Klaudia , Majka Grzegorz , Olszanecki Rafał 
Published: July 2022

AbstractThe adverse effects of air pollution on the cardiovascular system have been well documented. Nonalcoholic fatty liver disease (NAFLD) is an independent risk factor for cardiovascular events. However, the influence of exposure to airborne particles on the development of NAFLD is less recognised. The aim of this study was to investigate the impact of silica nanoparticles (SiNPs) on the development of liver steatosis. We used molecular and proteomic SWATH-MS methods to investigate the changes in the liver proteome of apolipoprotein E-knockout mice (apoE−/− mice) exposed to SiNPs for 4 months in a whole-body exposure chamber. Exposure to SiNPs evoked microvesicular liver steatosis in apoE−/− mice. Quantitative liver proteomics showed significant downregulation of ribosomal proteins and endoplasmic reticulum proteins. Gene expression analysis revealed a reduced level of proteins related to endoplasmic reticulum stress. Treatment with SiNPs decreased mitochondrial membrane potential and increased the production of reactive oxygen species in cultured HepG2 cells. This is the first report that inhalation exposure to SiNPs induces microvesicular steatosis and significant changes in the liver proteome in vivo. Our results highlight the important role of silica and point to the ER stress response and mitochondrial dysfunction as potential mechanisms responsible for the increase in fatty liver by SiNPs.
Innovationskrise im staatlichen Theatersektor? Eine Längsschnitt-Analyse für Theater in Nordrhein-Westfalen, 1995–2018
Authors: Glasow Maria , Heinze Thomas 
Published: July 2022

ZusammenfassungDer vorliegende Beitrag untersucht die kulturelle Innovationstätigkeit staatlicher deutscher Theater am Beispiel des bevölkerungsreichsten Bundeslandes Nordrhein-Westfalen (NRW). Während bisherige Diagnosen, einschließlich die sozialstrukturell geprägte Publikumsforschung, die Nachfrageseite in den Mittelpunkt stellen und dabei vor allem den stetigen Rückgang und die Alterung des Publikums diagnostizieren, geht unsere Analyse auf die Angebotsseite ein, insbesondere die Zahl von Ur- und Erstaufführungen und ihre Übernahme ins Repertoire. Der Beitrag zeigt, dass die bisherigen Anstrengungen der kommunalen und landeseigenen Theater, die Anzahl der Spielstätten und der dort aufgeführten Stücke zu erhöhen, nicht ausgereicht haben, um den Rückgang des Publikums zu stabilisieren. Gleichzeitig werden nur wenige neue Stücke auf den Spielplan gesetzt, von welchen sich noch weniger langfristig im Repertoire etablieren können. Unseren Ergebnissen zufolge wird der Theatersektor seine Erneuerungsfähigkeit nur sichern können, wenn eine Verschiebung hin zu deutlich mehr neuen Stücken erfolgt, die neues Publikum anziehen. Ein für Erneuerung grundsätzlich günstiger institutioneller Kontext ist der dezentrale Wettbewerb, der den Theatersektor in NRW prägt.
Synthesis of Polymer Precursor 12-Oxododecenoic Acid Utilizing Recombinant Papaya Hydroperoxide Lyase in an Enzyme Cascade
Authors: Coenen Anna , Marti Valentin Gala , Müller Kira , Sheremetiev Maria , Finamore Lorenzo , Schörken Ulrich 
Published: July 2022

AbstractHydroperoxide lyases (HPLs) catalyze the splitting of 13S-hydroperoxyoctadecadienoic acid (13S-HPODE) into the green note flavor hexanal and 12-oxo-9(Z)-dodecenoic acid, which is not yet used industrially. Here, HPL from Carica papaya (HPLCP) was cloned and functionally expressed in Escherichia coli to investigate synthesis of 12-oxo-9(Z)-dodecenoic acid in detail. To improve the low catalytic activity of full-length HPLCP, the hydrophobic, non-conserved N-terminal sequence was deleted. This enhanced enzyme activity from initial 10 to 40 U/l. With optimization of solubilization buffer, expression media enzyme activity was increased to 2700 U/l. The tetrameric enzyme was produced in a 1.5 l fermenter and enriched by affinity chromatography. The enzyme preparation possesses a slightly acidic pH optimum and a catalytic efficiency (kcat/KM) of 2.73 × 106 s−1·M−1 towards 13S-HPODE. Interestingly, HPLCP-N could be applied for the synthesis of 12-oxo-9(Z)-dodecenoic acid, and 1 mM of 13S-HPODE was transformed in just 10 s with a yield of 90%. At protein concentrations of 10 mg/ml, the slow formation of the 10(E)-isomer traumatin was observed, pointing to a non-enzymatic isomerization process. Bearing this in mind, a one-pot enzyme cascade starting from safflower oil was developed with consecutive addition of Pseudomonas fluorescens lipase, Glycine max lipoxygenase (LOX-1), and HPLCP-N. A yield of 43% was obtained upon fast extraction of the reaction mixtures after 1 min of HPLCP-N reaction. This work provides first insights into an enzyme cascade synthesis of 12-oxo-9(Z)-dodecenoic acid, which may serve as a bifunctional precursor for bio-based polymer synthesis.
Endoscopic surveillance alone is feasible and safe in type I gastric neuroendocrine neoplasms less than 10 mm in diameter
Authors: Exarchou Klaire , Hu Haiyi , Stephens Nathan A. , Moore Andrew R. , Kelly Mark , Lamarca Angela , Mansoor Wasat , Hubner Richard , McNamara Mairéad G. , Smart Howard , Howes Nathan R. , Valle Juan W. , Pritchard D. Mark 
Published: July 2022

Abstract
Purpose
Type I gastric neuroendocrine neoplasms (g-NENs) have a low risk of metastasis and a generally favourable prognosis. Patients with small type I g-NENs (≤10 mm) frequently require no treatment, whereas those with larger polyps usually undergo resection. We evaluated the safety and outcomes of endoscopic surveillance after no initial treatment in selected patients with type I g-NENs.

Methods
Retrospective analysis of type I g-NEN patients across two European Neuroendocrine Tumour Society Centers of Excellence 2003–2019.

Results
Following initial assessment, 87 of 115 patients with type I g-NEN (75 with polyps ≤10 mm) received no initial treatment and underwent endoscopic surveillance. 79/87 (91%) demonstrated no clinically meaningful change in tumour size or grade over a median 62 month follow up. Only two patients developed NEN progression that required a change in management and two other patients developed gastric adenocarcinoma/high grade dysplasia; all four initially had ≥11 mm g-NENs.

Conclusions
Patients with ≤10 mm type I g-NENs were unlikely to develop clinically significant tumour progression and in most cases, resection was not needed. The endoscopic surveillance interval could therefore potentially be safely increased to every 2–3 years in such patients. However, lifelong surveillance is still advocated due to the additional risk of developing gastric adenocarcinoma.