bluuebunny/crossref_metadata_2025_split huggingface dataset:
Species prevalence, antimicrobial susceptibility and detection of virulence factors of enterococci isolated from tertiary care hospital
Authors: Sachan Sadhana , Anubhaw Anubhaw 
Published: August 2022

Introduction: Emergence of multidrug resistant nosocomial enterococcus strains emphasizes the need for further investigating enterococci. Objectives: To characterize enterococci from various clinical specimens, to determine the antimicrobial susceptibility pattern and to explore the association between virulence factors and antimicrobial resistance. Material and Methods: Two hundred and eighty three clinical isolates of enterococcus were speciated and subjected to antimicrobial susceptibility testing using Kirby Bauer disc diffusion method. They were screened for vancomycin resistance by vancomycin screening agar method as recommended by Clinical Laboratory Standards Institute 2014, and confirmed by determination of minimum inhibitory concentration using agar dilution and E test. Genotypic confirmation was done by polymerase chain reaction. Virulence factors (haemolysin, gelatinase and biofilm production) were detected phenotypically. Results: Of the 283 enterococci isolated, 12 species were identified; predominant species was Enterococcus faecalis (82.33%). High level gentamicin resistance (HLGR) and vancomycin resistance were observed among 55.57% and 6.01% of Enterococcus isolates respectively. All vancomycin resistant enterococci (VRE) were Enterococcus faecalis and had vanA phenotype and genotype. Sensitivity to linezolid was 100 per cent among enterococci. Hemolysin, gelatinase and biofilm production were seen in 15.90%, 12.36% and 13.43% of enterococcal isolates respectively.
Would augmentation genioplasty using patient-specific PEEK (Polyether Ether Ketone) implant meet patient’s expectations?
Authors: Adb El-Aty Salma Hassan , Yassin Salah , El-Monim Ghada Abd 
Published: August 2022

Introduction: Patient-specific implants become very valuable in restoring facial contours, including the chin area. Evaluation of patient satisfaction with the esthetic results should be a primary concern. Aim of study: To evaluate the success of augmentation genioplasty using patient-specific PEEK (Polyether Ether Ketone) implant in meeting patient’s expectations. Methods: Seven patients were enrolled in this study. They were all having deficient chin that was managed by augmentation genioplasty using patient-specific PEEK implant. Preoperative clinical evaluation was performed for all patients. With the help of MIMICS and 3-MATIC soft wares, diagnosis, virtual planning and final implant design were done. Finally, STL file was sent for milling using PEEK material. Under GA, PSI was inserted through an intra-oral vestibular approach and fixed to the underlying bone using mini-screws. Patient expectations were evaluated by Face-Q questionnaire. Result: The study was conducted on 7 cases, 3(42.9%) of which were males and 4(57.1%) were females. The mean age of the cases was (22.00±1.29) years. All patients showed high degree of contentment with the procedure. Conclusions: Patient-specific PEEK implant can be used for chin augmentation with good esthetic results close to that of patients’ expectations.
Pengaruh Iklan Promosi Penjualan Personal Branding Terhadap Kepuasan Produk Perahu Sekoci PT Jatitengah Perdana Indonesia
Authors: Ilahi Andi Alfianto Anugrah 
Published: August 2022

Penelitian ini bertujuan untuk mengetahui pengaruh periklanan, promosi penjualan, dan penjualan perseorangan terhadap kepuasan konsumen produk perahu sekoci PT. Jatitengah Perdana Indonesia secara parsial dan simultan. Sampel dalam penelitian ini adalah konsumen produk perahu sekoci PT. Jatitengah Perdana Indonesia yang berjumlah 40 perusahaan. Metode pengambilan sampel dilakukan dengan metode non probability sampling dengan teknik judgement sampling. Metode pengumpulan data yang digunakan adalah kuesioner (angket), dokumentasi dan wawancara. Metode analisis yang digunakan dalam penelitian ini adalah uji instrumen (uji validitas dan uji reliabilitas), analisis deskriptif persentase, uji asumsi klasik, analisis regresi berganda, pengujian hipotesis, dan koefisien determinasi dengan menggunakan SPSS. Hasil penelitian diperoleh persamaan regresi linier berganda Y = 12,958 + 0,174 X1 + 0,210 X2 + 0,267 X3. Koefisien determinasi (Adjusted R2) sebesar 0,370, hal ini berarti 37 % kepuasan konsumen produk perahu sekoci PT.Jatitengah Perdana Indonesia dipengaruhi oleh periklanan, promosi penjualan, dan penjualan perseorangan, sedangkan sisanya 63% dipengaruhi oleh variabel lain yang berada di luar variabel yang diteliti dalam penelitian ini.
Whose Islam? The Western University and Modern Islamic Thought in Indonesia
Authors: Jalaluddin Mufti Labib 
Published: August 2022

Megan Brankley Abbas, Whose Islam? The Western University and Modern Islamic Thought in Indonesia, USA: Stanford University Press, 2021. For centuries, Islamic schools or madrasa have been the primary source of Muslim religious authority, with Indonesia no exception in this regard. For generations, Indonesia’s foremost Muslim leaders have received their Islamic education from Middle Eastern madrasas. In her book Whose Islam?, Megan Brankley Abbas challenges the notion of Middle Eastern centrality in Islamic education by arguing that Western universities has emerged as significant sites for the production of Islamic knowledge and Muslim religious authority in the last century. In her research, Abbas examines the far-reaching repercussions of this change for Muslim communities across the globe and for the future of Islamic studies as an academic discipline.
Performance analysis of control allocation using data‐driven integral quadratic constraints
Authors: Pusch Manuel , Ossmann Daniel , Pfifer Harald 
Published: August 2022

AbstractA new method is presented for evaluating the performance of a nonlinear control allocation system within a linear control loop. To that end, a worst‐case gain analysis problem is formulated that can be readily solved by means of well‐established methods from robustness analysis using integral quadratic constraints (IQCs). It exploits the fact that control allocation systems are in general memoryless mappings that can be bounded by IQCs. A data‐driven approach is used to find an optimal bound of the input/output mapping of the control allocation. Additionally, an iterative procedure based on local IQCs is introduced to determine meaningful sampling limits for less conservative yet accurate results. The effectiveness of the proposed data‐driven performance analysis is shown at the example of an actively controlled flexible wing in a wind tunnel.
In Vivo 3‐Photon Fluorescence Imaging of Mouse Subcortical Vasculature Labeled by AIEgen Before and After Craniotomy
Authors: Deng Xiangquan , Xu Zhourui , Zhang Zhijun , Zhang Wanjian , Li Jiangao , Zheng Lei , Chen Xinlin , Pan Yi , Qiu Ping , Wang Dong , Xu Gaixia , Wang Ke 
Published: August 2022

AbstractFluorophores lay the material basis for tissue labeling and fluorescence imaging, especially for deep‐brain multiphoton microscopy (MPM) in animal models. Among various fluorescent materials, those with aggregation‐induced emission (AIE) characteristics, i.e., AIEgens, have excellent optical properties and biocompatibility and thus have found widespread applications in biomedical imaging. However, their application to deep‐brain MPM has so far been limited in imaging depth, which undoubtedly poses a hindrance to neurological research aiming to probe the deeper brain. In order to address the issue, here a novel bright AIEgen, namely MTTCM, is designed and synthesized via facile reactions routes. The self‐assembled MTTCM nanoparticles (NPs) with their water‐dispersible feature, have good biocompatibility and good photostability. Furthermore, they are spectrally advantageous for deep‐brain MPM: their emission lies in the NIR‐I region, they generate 3‐photon fluorescence with NIR‐III excitation and show only a slight blue‐shift in the emitted 3‐photon fluorescence in vivo. From a fundamental photochemical perspective, it is also confrimed that MTTCM NPs obey Kasha's rule since the measured 3‐photon and 1‐photon fluorescence spectra overlap. All these merits make MTTCM NPs the enabling fluorophores for record depth in brain imaging in vivo: 1905 µm after craniotomy and 1100 µm through an intact skull, excited at 1660 nm. Furthermore, a record 752 µm hemodynamic imaging depth before craniotomy is demonstrated, from which the blood flow speed can be measured. MTTCM NPs are thus promising fluorophores for deep‐brain 3‐photon imaging in vivo.
Expanding Structural Space for Immunomodulatory Nucleic Acid Nanoparticles via Spatial Arrangement of Their Therapeutic Moieties
Authors: Chandler Morgan , Rolband Lewis , Johnson M. Brittany , Shi Da , Avila Yelixza I. , Cedrone Edward , Beasock Damian , Danai Leyla , Stassenko Elizabeth , Krueger Joanna K. , Jiang Jiancheng , Lee Jeoung Soo , Dobrovolskaia Marina A. , Afonin Kirill A. 
Published: August 2022

AbstractDifferent therapeutic nucleic acids (TNAs) can be unified in a single structure by their elongation with short oligonucleotides designed to self‐assemble into nucleic acid nanoparticles (NANPs). With this approach, therapeutic cocktails with precisely controlled composition and stoichiometry of active ingredients can be delivered to the same diseased cells for enhancing pharmaceutical action. In this study, an additional nanotechnology‐based therapeutic option that enlists a biocompatible NANP‐encoded platform for their controlled patient‐specific immunorecognition is explored. For this, a set of representative functional NANPs is extensively characterized in vitro, ex vivo, and in vivo and then further analyzed for immunostimulation of human peripheral blood mononuclear cells freshly collected from healthy donor volunteers. The results of the study present the advancement of the current TNA approach toward personalized medicine and offer a new strategy to potentially address top public health challenges related to drug overdose and safety through the biodegradable nature of the functional platform with immunostimulatory regulation.
Enantiomer‐Selective Molecular Sensing in the Nonlinear Optical Regime via Upconverting Chiral Metamaterials
Authors: Lee Kyu‐Tae , Kim Byunghoon , Raju Lakshmi , Rodrigues Sean P. , Ko Doo‐Hyun , Cai Wenshan 
Published: August 2022

AbstractEnantiomers are chiral isomers in which the isomer's structure itself and its mirror image cannot be superimposed on each other. Enantiomer selective sensing is critical as enantiomers exhibit distinct functionalities to their mirror image. Discriminating between enantiomers by optical methods has been widely used as these techniques provide nondestructive characterization, however, they are constrained by the intrinsically small chirality of the molecules. Here, a method to effectively discriminate chiral analytes in the nonlinear regime is demonstrated, which is facilitated by an upconverting chiral plasmonic metamaterial. The different handedness of the chiral molecules interacts with the chiral metamaterial platform, which leads to a change in the circular dichroism of the chiral metamaterial in the near‐infrared region. The contrast of the circular dichroism is identified by the upconverted signal in the visible region.
All‐Solid‐State Thin Film Lithium/Lithium‐Ion Microbatteries for Powering the Internet of Things
Authors: Xia Qiuying , Zan Feng , Zhang Qianyu , Liu Wei , Li Qichanghao , He Yan , Hua Jingyi , Liu Jiahao , Xu Jing , Wang Jinshi , Wu Chuanzhi , Xia Hui 
Published: August 2022

AbstractAs the world steps into the era of Internet of Things (IoT), numerous miniaturized electronic devices requiring autonomous micropower sources will be connected to the internet. All‐solid‐state thin‐film lithium/lithium‐ion microbatteries (TFBs) combining solid‐state battery architecture and thin‐film manufacturing are regarded as ideal on‐chip power sources for IoT‐enabled microelectronic devices. However, unlike commercialized lithium‐ion batteries, TFBs are still in the immature state, and new advances in materials, manufacturing, and structure are required to improve their performance. In this review, the current status and existing challenges of TFBs for practical application in internet‐connected devices for the IoT are discussed. Recent progress in thin‐film deposition, electrode and electrolyte materials, interface modification, and 3D architecture design is comprehensively summarized and discussed, with emphasis on state‐of‐the‐art strategies to improve the areal capacity and cycling stability of TFBs. Moreover, to be suitable power sources for IoT devices, the design of next‐generation TFBs should consider multiple functionalities, including wide working temperature range, good flexibility, high transparency, and integration with energy‐harvesting systems. Perspectives on designing practically accessible TFBs are provided, which may guide the future development of reliable power sources for IoT devices.
Flat–Zigzag Interface Design of Chalcogenide Heterostructure toward Ultralow Volume Expansion for High‐Performance Potassium Storage
Authors: Pan Qingguang , Tong Zhaopeng , Su Yuanqiang , Zheng Yongping , Shang Lin , Tang Yongbing 
Published: August 2022

AbstractHeterostructure construction of layered metal chalcogenides can boost their alkali‐metal storage performance, where the charge transfer kinetics can be promoted by the built‐in electric fields. However, these heterostructures usually undergo interface separation due to severe layer expansion, especially for large‐size potassium accommodation, resulting in the deconstruction of heterostructures and battery performance fading. Herein, first a stable interface design strategy where two metal chalcogenides with totally different layer‐morphologies are stacked to form large K+ transport channels, rendering ultralow interlayer expansion, is presented. As a proof of concept, the flat–zigzag MoS2/Bi2S3 heterostructures stacked with zigzag‐morphology Bi2S3 and flat‐morphology MoS2 present an ultralow expansion ratio (1.98%) versus MoS2 (9.66%) and Bi2S3 (9.61%), which deliver an ultrahigh potassium storage capacity of above 600 mAh g−1 and capacity retention of 76% after 500 cycles, together with the built‐in electric field of heterostructures. Once the heterostructures are used as an anode for potassium‐based dual‐ion batteries (K‐DIBs), it achieves a superior full‐cell capacity of ≈166 mAh g−1 with a capacity retention of 71% after 400 cycles, which is an outstanding performance among the reported K‐DIBs. This proposed interface stacking strategy may offer a new way toward stable heterostructure design for metal ions storage and transport applications.
4D Printing of Freestanding Liquid Crystal Elastomers via Hybrid Additive Manufacturing
Authors: Peng Xirui , Wu Shuai , Sun Xiaohao , Yue Liang , Montgomery S. Macrae , Demoly Frédéric , Zhou Kun , Zhao Ruike Renee , Qi H. Jerry 
Published: August 2022

AbstractLiquid crystal elastomers (LCE) are appealing candidates among active materials for 4D printing, due to their reversible, programmable and rapid actuation capabilities. Recent progress has been made on direct ink writing (DIW) or Digital Light Processing (DLP) to print LCEs with certain actuation. However, it remains a challenge to achieve complicated structures, such as spatial lattices with large actuation, due to the limitation of printing LCEs on the build platform or the previous layer. Herein, a novel method to 4D print freestanding LCEs on‐the‐fly by using laser‐assisted DIW with an actuation strain up to −40% is proposed. This process is further hybridized with the DLP method for optional structural or removable supports to create active 3D architectures in a one‐step additive process. Various objects, including hybrid active lattices, active tensegrity, an actuator with tunable stability, and 3D spatial LCE lattices, can be additively fabricated. The combination of DIW‐printed functionally freestanding LCEs with the DLP‐printed supporting structures thus provides new design freedom and fabrication capability for applications including soft robotics, smart structures, active metamaterials, and smart wearable devices.
Multispectral Large‐Panel X‐ray Imaging Enabled by Stacked Metal Halide Scintillators
Authors: Ran Peng , Yang Lurong , Jiang Tingming , Xu Xuehui , Hui Juan , Su Yirong , Kuang Cuifang , Liu Xu , Yang Yang (Michael) 
Published: August 2022

AbstractConventional energy‐integration black–white X‐ray imaging lacks the spectral information of X‐ray photons. Although X‐ray spectra (energy) can be distinguished by the photon‐counting technique typically with CdZnTe detectors, it is very challenging to be applied to large‐area flat‐panel X‐ray imaging (FPXI). Herein, multilayer stacked scintillators of different X‐ray absorption capabilities and scintillation spectra are designed; in this scenario, the X‐ray energy can be discriminated by detecting the emission spectra of each scintillator; therefore, multispectral X‐ray imaging can be easily obtained by color or multispectral visible‐light camera in a single shot of X‐rays. To verify this idea, stacked multilayer scintillators based on several emerging metal halides are fabricated in a cost‐effective and scalable solution process, and proof‐of‐concept multispectral (or multi‐energy) FPXI are experimentally demonstrated. The dual‐energy X‐ray image of a “bone–muscle” model clearly shows the details that are invisible in conventional energy‐integration FPXI. By stacking four layers of specifically designed multilayer scintillators with appropriate thicknesses, a prototype FPXI with four energy channels is realized, proving its extendibility to multispectral or even hyperspectral X‐ray imaging. This study provides a facile and effective strategy to realize multispectral large‐area flat‐panel X‐ray imaging.
Elastin‐Like Polypeptides Facilitate Adeno‐Associated Virus Transduction in the Presence of Pre‐Existing Neutralizing Antibodies
Authors: Wang Kai , Zheng Min , Askew Charles , Zhang Xintao , Li Chengwen , Han Zongchao 
Published: August 2022

AbstractAdeno‐associated virus (AAV) is successfully developed as a major gene therapy vector, but it is still susceptible to a significant delivery limitation specifically when the vector encounters neutralizing antibodies from a pre‐existing immune response or at readministration. Here thermoresponsive polymer elastin‐like polypeptides (ELPs) are utilized to crosslink with AAV serotypes 2, 8, and 9 and polyplex AAV vectors are formed by creating a shield of nonviral polymer around them in nanoscale. Neutralizing antibody (NAb) assays are performed which reveal that ELP‐AAV nanoparticles significantly improve expression at high NAb titers for AAV 2 and 9. The ELP‐AAV nanoparticles are stable for an extended period in neutralizing serum and ELP appears to follow the AAV capsid during uncoating and degradation. No toxicity is found after subretinal, intramuscular, and retro‐orbital injections of ELP‐AAV. After passive transfer of human NAbs in vivo, ELP‐AAV significantly increases transduction at a low systemic AAV dose (1012 vg kg−1) in mice compared to free AAV. In an in vivo readministration paradigm, ELP‐AAV significantly improves the reporter gene expression compared to free AAV and does not change the AAV tropism. This method has strong potential to overcome the AAV‐associated neutralizing antibody response in gene therapy without redesigning the AAV virion.
Assessment of the beliefs, needs, and expectations for genetic counseling of patients with hypermobile Ehlers‐Danlos syndrome
Authors: Ahimaz Priyanka , Kramer Tamar , Swaroop Pooja , Mitchell McKenzie , Hernan Rebecca , Anyane‐Yeboa Kwame , Pereira Elaine M. 
Published: August 2022

AbstractEhlers‐Danlos syndrome, hypermobility type (hEDS) is a heritable connective tissue disorder that currently does not have a known molecular etiology. Previous studies have explored the complex symptomology, clinical diagnosis, and psychological aspects of hEDS. Genetics providers currently aid in the diagnosis and management guidance of patients with hEDS, but there is limited data describing the needs and expectations of individuals with hEDS from a clinical genetics appointment. Our study sought to explore these items through the use of an online survey to assess participants' beliefs, needs and expectations (BNE) for genetic counseling as well as questions about demographics, hEDS symptoms, and current medical care. A total of 460 respondents with hEDS completed the survey. Most participants felt joint pain/weakness (n = 392; 88%) was one of the most disruptive symptoms of hEDS and 63% (n = 289) reported having psychiatric conditions. BNE scores were highest in two domains: expectations to have psychosocial concerns addressed during a genetic counseling appointment (mean score = 4.4/5; SD = 0.56) and desire for positive feelings after a genetic counseling session (mean score = 4.3/5; SD = 0.59). Participants who previously had genetic counseling felt less unsure about their diagnosis (p = 0.02) and had lower need for information about hEDS (p < 0.001). Majority of participants did not feel that their doctors were knowledgeable about hEDS (n = 269; 58%) and strongly supported a multidisciplinary approach to their care (n = 445; 97%). This research provides a framework for genetics providers and other healthcare professionals to assess the needs and expectations of patients with hEDS and consider re‐structuring their appointment formats to service this population.
Cerebral Amyloid Angiopathy and the Risk of Hematoma Expansion
Authors: Seiffge David J. , Polymeris Alexandros A. , Law Zhe Kang , Krishnan Kailash , Zietz Annaelle , Thilemann Sebastian , Werring David , Al‐Shahi Salman Rustam , Dineen Robert A. , Engelter Stefan T. , Bath Philip M. , Sprigg Nikola , Lyrer Philippe , Peters Nils ,   for the TICH‐2 Investigators
Published: August 2022

ObjectiveWe assessed whether hematoma expansion (HE) and favorable outcome differ according to type of intracerebral hemorrhage (ICH).MethodsAmong participants with ICH enrolled in the TICH‐2 (Tranexamic Acid for Hyperacute Primary Intracerebral Haemorrhage) trial, we assessed baseline scans for hematoma location and presence of cerebral amyloid angiopathy (CAA) using computed tomography (CT, simplified Edinburgh criteria) and magnetic resonance imaging (MRI; Boston criteria) and categorized ICH as lobar CAA, lobar non‐CAA, and nonlobar. The main outcomes were HE and favorable functional outcome. We constructed multivariate regression models and assessed treatment effects using interaction terms.ResultsA total of 2,298 out of 2,325 participants were included with available CT (98.8%; median age = 71 years, interquartile range = 60‐80 years; 1,014 female). Additional MRI was available in 219 patients (9.5%). Overall, 1,637 participants (71.2%) had nonlobar ICH; the remaining 661 participants (28.8%) had lobar ICH, of whom 202 patients had lobar CAA‐ICH (8.8%, 173 participants according to Edinburgh and 29 participants according to Boston criteria) and 459 did not (lobar non‐CAA, 20.0%). For HE, we found a significant interaction of lobar CAA ICH with time from onset to randomization (increasing risk with time,pinteraction < 0.001) and baseline ICH volume (constant risk regardless of volume,pinteraction < 0.001) but no association between type of ICH and risk of HE or favorable outcome. Tranexamic acid significantly reduced the risk of HE (adjusted odds ratio = 0.7, 95% confidence interval = 0.6–1.0,p = 0.020) without statistically significant interaction with type of ICH (pinteraction = 0.058). Tranexamic acid was not associated with favorable outcome.InterpretationRisk of HE in patients with lobar CAA‐ICH was not independently increased but seems to have different dynamics compared to other types of ICH. The time window for treatment of CAA‐ICH to prevent HE may be longer. ANN NEUROL 2022;92:921–930