bluuebunny/crossref_metadata_2025_split huggingface dataset:
Latihan plyometric dalam sepakbola untuk anak usia muda
Authors: Komarudin Komarudin 
Published: September 2022

Sepakbola adalah permainan dengan intensitas tinggi yang membutuhkan banyak keterampilan fisik selama permainan berlangsung. Dibutuhkan latihan yang mampu menunjang sifat permainan sepakbola yang membutuhkan kelincahan, kecepatan, daya ledak dan koordinasi. Latihan dengan intensitas dan beban yang tinggi berpotensi cidera. Di tingkat profesional pria elit dalam sepak bola, hampir sepertiga dari semua cedera yang berhubungan dengan sepak bola berhubungan dengan otot, dengan mayoritas mempengaruhi hal-hal berikut kelompok otot utama pada ekstremitas bawah: paha belakang (37%), otot perut (23%), paha depan (19%), dan otot betis (13%). Pelatihan plyometric memiliki manfaat yang luar biasa yang berpotensi sebagai metode pelatihan untuk meningkatkan daya ledak untuk sepak bola, Diperkenalkan dan diajarkan sejak usia muda agar dapat memberikan bekal atlet dalam mempersiapkan kebutuhan fisik mereka dalam permainan yang intensif dan menjaga mereka dari cidera di masa depan. Plyometric exercises in football for young children Abstract: Football is a high-intensity game that requires a lot of physical skill throughout the game. It takes practice that is able to support the nature of the game of football which requires agility, speed, explosive power and coordination. Exercise with high intensity and load has the potential for injury. At the elite male professional level in soccer, nearly a third of all soccer-related injuries are muscle-related, with the majority affecting the following major muscle groups in the lower extremities: hamstrings (37%), abdominal muscles (23%), quadriceps (19%), and calf muscles (13%). Plyometric training has tremendous benefits that have the potential as a training method to increase explosive power for soccer. Introduced and taught from a young age in order to equip athletes to prepare for their physical needs in intensive games and protect them from future injuries.
Kontribusi kepercayaan diri dan efikasi diri akademik terhadap nilai mata kuliah statistik inferensial
Authors: Kholidin Farid Imam , Rachmawati Indriyana , Laksana Eko Pramudya 
Published: September 2022

Tujuan dari penelitian ini adalah untuk: mengidentifikasi kontribusi simultan dari kepercayaan diri akademik dan self-efficacy akademik ke nilai akhir matakuliah Statistik Inferensial; mengidentifikasi kontribusi parsial kepercayaan diri akademik ke nilai akhir matakuliah Statistik Inferensial; mengidentifikasi kontribusi parsial dari self-efficacy akademik ke nilai akhir matakuliah Statistik Inferensial; dan mengidentifikasi kontribusi kepercayaan diri akademik dan self-efficacy akademik pada nilai akhir matakuliah Statistik Inferensial. Penelitian ini menggunakan kuantitatif. Hasil penelitian menunjukkan bahwa: ada kontribusi simultan kepercayaan diri akademik dan self-efficacy akademik padanilai akhir matakuliah Statistik Inferensial; belum ada kontribusi parsial kepercayaan diri akademik pada nilai akhir matakuliah Statistik Inferensial; ada kontribusi parsial dari self-efficacy akademik pada nilai akhir matakuliah Statistik Inferensial; dan kontribusi kepercayaan diri akademik dan self-efficacy akademik untuk nilai akhir kursus Statistik Inferensial sebesar 42,90%. Contribution of self-confidence and academic self-efficacy to students' final semester grade AbstractThe objectives of the study were to: identify the simultaneous contribution of academic self-confidence and academic self-efficacy to the final grade of Inferential Statistics course; identify the partial contribution of academic self-confidence to the final grade of Inferential Statistics course; identify the partial contribution of academic self-efficacy to the final grade of Inferential Statistics course; and identify the contribution size of academic self-confidence and academic self-efficacy to the final grade of Inferential Statistics course. In conducting the study, the quantitative method was implemented. Results showed that: there has been simultaneous contribution of academic self-confidence and academic self-efficacy to the final grade of Inferential Statistics course; there has not been partial contribution of academic self-confidence to the final grade of Inferential Statistics course; there has been partial contribution of academic self-efficacy to the final grade of Inferential Statistics course; and the contribution of academic self-confidence and academic self-efficacy to the final grade of Inferential Statistics course has been 42.90%.
Ortaokul Öğrencilerinde Oyun Bağımlılığı ile Sorumluluk Duygusu-Davranışı ve Sosyal Beceriler
Authors: Arslan Ayşe , Taş İbrahim 
Published: September 2022

Bu araştırmanın amacı ortaokul öğrencilerinde oyun bağımlılığı ile sorumluluk duygusu-davranışı ve sosyal beceri arasındaki ilişkiyi incelemektir. Çalışma 341 (%68.2) kız, 159 (%31.8) erkek olmak üzere toplam 500 öğrenci üzerinde yapılmıştır. Araştırmada veri toplama aracı olarak, Sorumluluk Duygusu ve Davranışı Değerlendirme Ölçeği (SSDÖ), Ergenler İçin Oyun Bağımlılığı Ölçeği, Sosyal Beceriler Ölçeği ve araştırmacının oluşturduğu kişisel bilgi formu kullanılmıştır. Elde edilen veriler İlişkisiz Grup t Testi, Pearson Momentler Çarpım Korelasyon Analizi ve Çoklu Regresyon testleri ile analiz edilmiştir. Araştırma sonucunda oyun bağımlılığı ile sosyal beceri ve sorumluluk duygusu-davranışı arasında anlamlı ve negatif yönde bir ilişki bulunmuştur. Sorumluluk duygusu-davranışı ve sosyal beceriler arasında pozitif yönde bir ilişki bulunmuştur. Sorumluluk duygusu- davranışının oyun bağımlılığını anlamlı bir şekilde yordadığı, sosyal becerinin ise oyun bağımlılığını anlamlı bir şekilde yordamadığı tespit edilmiştir.
СУЧАСНИЙ СТАН ВИКОРИСТАННЯ ЦИФРОВИХ ЗАСОБІВ ДЛЯ ОРГАНІЗАЦІЇ ДИСТАНЦІЙНОГО НАВЧАННЯ В ЗАКЛАДАХ ЗАГАЛЬНОЇ СЕРЕДНЬОЇ ОСВІТИ: РЕЗУЛЬТАТИ ОПИТУВАННЯ 2022
Authors: Биков Валерій Юхимович , Овчарук Оксана Василівна , Іванюк Ірина Володимирівна , Пінчук Ольга Павлівна , Гальпєріна Вікторія Олегівна 
Published: September 2022

Стаття висвітлює сучасний стан використання цифрових засобів для організації дистанційного навчання учнів у закладах загальної середньої освіти в Україні на основі онлайн-опитування педагогічних працівників, проведеного у період з 25 січня по 25 лютого 2022 року Інститутом цифровізації освіти НАПН України. Третій рік поспіль українська система освіти, як і освітні системи інших країн, опинилась перед викликами, пов’язаними з необхідністю інтенсивно провадити дистанційне навчання в закладах освіти з огляду на карантинні заходи в умовах пандемії COVID-19. В опитуванні 2022 р. взяли участь 54 254 особи різних категорій освітян, зокрема: вчителі та керівники закладів загальної середньої освіти (ЗЗСО), методисти системи післядипломної педагогічної освіти, практичні психологи закладів освіти. Основні питання анкети, що становили три блоки, стосувались (1) організації дистанційного навчання на практиці, (2) стану готовності до використання цифрових засобів для підготовки та проведення освітніх заходів вчителями ЗЗСО, а також (3) визначення їхніх потреб та можливостей освітніх ресурсів, електронних засобів навчання, що користуються найбільшим попитом. Новизна опитування базується на виокремленні та використанні під час опитування категорій цифрової компетентності вчителя, узгоджених з міжнародними рамками цифрової компетентності громадян, зокрема Рамкою цифрової компетентності DigComp 2.0 та 2.1 (The Digital Competence Framework for Citizens), розробленою європейською спільнотою. Наведено узагальнені дані результатів самооцінювання педагогічними працівниками їх цифрової компетентності. Здійснено порівняння результатів онлайн-опитувань учителів у 2020, 2021 та 2022 роках і виокремлено динаміку використання вчителями цифрових засобів для організації дистанційного навчання. Надано висновки, що сприятимуть практичному використанню результатів опитування органами управління освітою, закладами та установами з підвищення кваліфікації вчителів, закладами загальної середньої освіти, науковими установами та іншими зацікавленими сторонами при організації необхідних заходів, реалізація яких сприятиме успішному використанню ІКТ та здійсненню дистанційного навчання в Україні.
PERBANDINGAN METODE LATIHAN CIRCUIT DAN INTERVAL TERHADAP VO2MAX ATLET BULUTANGKIS USIA 10-14 TAHUN PWS GODEAN SLEMAN
Authors: Alexander Bimo 
Published: September 2022

Penelitian ini bertujuan untuk membandingkan circuit training dan interval training terhadap VO2Max pada atlet bulutangkis Usia 10-14 tahun PWS Godean Sleman. Penelitian ini merupakan penelitian eksperimen menggunakan two group pretest-posttest design. Populasinya atlet PB PWS Godean Sleman, sampel menggunakan purposive sampling dengan pertimbangan usia 10-14 tahun berjumlah 16 atlet putra. Analisis data menggunakan uji prasyarat dilanjutkan uji hipotesis yaitu uji-t. Berdasarkan hasil penelitian diketahui bahwa metode circuit training meningkatkan kemampuan Vo2max dengan nilai t hitung 12,188 > t tabel = 2.36 dengan nilai signifikansi 0,00 dan perbedaan nilai rata-rata yaitu sebesar 8,40. dengan kenaikan persentase sebesar 20,19%. Kemudian metode interval training meningkatkan kemampuan Vo2max dengan nilai t hitung 8,819 > t tabel = 2.36 dengan nilai signifikansi 0,00 dan perbedaan nilai rata-rata yaitu sebesar 8,84. dengan kenaikan persentase sebesar 20,97%. Kemudian tidak ada perbedaan yang signifikan antara metode circuit training dan interval training terhadap VO2Max pada atlet bulutangkis Usia 10-14 tahun PWS Godean Sleman dilihat dari t hitung sebesar 0,296 dan t-tabel (df =14) = 2,14, besarnya nilai signifikansi 0,771. Jadi, dapat disimpulkan bahwa kemampuan VO2Max pada atlet bulutangkis Usia 10-14 tahun PWS Godean Sleman dapat ditingkatkan melalui kedua metode latihan tersebut.
Whole genome sequencing of OXA-232-producing wzi93-KL112-O1 carbapenem-resistant Klebsiella pneumoniae in human bloodstream infection co-harboring chromosomal ISEcp1-based blaCTX-M-15 and one rmpA2-associated virulence plasmid
Authors: Tian Chongmei , Xing Mengyu , Zhao Yaping , Fan Xueyu , Bai Yongfeng , Fu Liping , Wang Siwei 
Published: September 2022

ObjectivesTo characterize one OXA-232-producing wzi93-KL112-O1 carbapenem-resistant Klebsiella pneumoniae (CRKP) co-harboring chromosomal blaCTX-M-15 and one rmpA2-associated virulence plasmid.MethodsMinimum inhibitory concentrations (MICs) were measured via broth microdilution method. Conjugation, chemical transformation, string test and Galleria mellonella infection model experiments were also conducted. Whole-genome sequencing (WGS) was performed on the Illumina and Nanopore platforms. Antimicrobial resistance determinants were identified using ABRicate program with ResFinder database. Insertion sequences (ISs) were identified using ISfinder. Bacterial virulence factors were identified using virulence factor database (VFDB). Wzi, capsular polysaccharide (KL) and lipoolygosaccharide (OCL) were analyzed using Kleborate with Kaptive. Phylogenetic analysis of 109 ST15 K. pneumoniae strains was performed using core genome multilocus sequence typing (cgMLST) on the Ridom SeqSphere+ server. MLST, replicons type, SNP strategies and another cgMLST analysis for 45 OXA-232-producing K. pneumoniae strains were further conducted using BacWGSTdb server.ResultsK. pneumoniae KPTCM strain belongs to ST15 with wzi93, KL112 and O1. It possessed a multidrug-resistant (MDR) profile and was resistant to carbapenems (meropenem and ertapenem), ciprofloxacin and amikacin. Virulence assays demonstrated KPTCM strain possesses a low virulence phenotype. WGS revealed it contained one circular chromosome and nine plasmids. The carbapenemase-encoding gene blaOXA-232 was located in a 6141-bp ColKP3-type non-conjugative plasmid and flanked by ΔISEcp1 and ΔlysR-ΔereA. Interestingly, blaCTX-M-15 was located in the chromosome mediated by ISEcp1-based transposon Tn2012. Importantly, it harbored a rmpA2-associated pLVPK-like virulence plasmid with iutA-iucABCD gene cluster and one IS26-mediated MDR fusion plasmid according to 8-bp (AGCTGCAC or GGCCTTTG) target site duplications (TSD). Based on the cgMLST and SNP analysis, data showed OXA-232-producing ST15 K. pneumoniae isolates were mainly isolated from China and have evolved in recent years.ConclusionsEarly detection of CRKP strains carrying chromosomal blaCTX-M-15, OXA-232 carbapenemase and pLVPK-like virulence plasmid is recommended to avoid the extensive spread of this high-risk clone.
Early ACEI/ARB use and in-hospital outcomes of acute myocardial infarction patients with systolic blood pressure <100 mmHg and undergoing percutaneous coronary intervention: Findings from the CCC-ACS project
Authors: Zhao Xuedong , Zhao Guanqi , Zhou Mengge , Wang Ge , Ma Changsheng , Smith Sidney C. , Fonarow Gregg C. , Morgan Louise , Que Bin , Ai Hui , Liu Jing , Zhao Dong , Nie Shaoping 
Published: September 2022

BackgroundFew studies have evaluated whether acute myocardial infarction (AMI) patients with relatively low blood pressure benefit from early ACEI/ARB use in the era of percutaneous coronary intervention (PCI).ObjectivesThis study evaluated the associations of ACEI/ARB use within 24 h of admission with in-hospital outcomes among AMI patients with SBP &lt; 100 mmHg and undergoing PCI.MethodsThis study was based on the Improving Care for Cardiovascular Disease in China-ACS project, a collaborative registry and quality improvement project of the American Heart Association and the Chinese Society of Cardiology. Between November 2014 and December 2019, a total of 94,623 patients with AMI were enrolled. Of them, 4,478 AMI patients with SBP &lt; 100 mmHg and undergoing PCI but without clinically diagnosed cardiogenic shock at admission were included. Multivariable logistic regression and propensity score-matching analysis were used to evaluate the association between early ACEI/ARB use and in-hospital major adverse cardiac events (MACEs), a combination of all-cause death, cardiogenic shock, and cardiac arrest.ResultsOf AMI patients, 24.41% (n = 1,093) were prescribed ACEIs/ARBs within 24 h of admission. Patients with early ACEI/ARB use had a significantly lower rate of MACEs than those without ACEI/ARB use (1.67% vs. 3.66%, p = 0.001). In the logistic regression analysis, early ACEI/ARB use was associated with a 45% lower risk of MACEs (odds ratio: 0.55, 95% CI: 0.33–0.93; p = 0.027). Further propensity score-matching analysis still showed that patients with early ACEI/ARB use had a lower rate of MACEs (1.96% vs. 3.93%, p = 0.009).ConclusionThis study found that among AMI patients with an admission SBP &lt; 100 mmHg undergoing PCI, early ACEI/ARB use was associated with better in-hospital outcomes. Additional studies of the early use of ACEIs/ARBs in AMI patients with relatively low blood pressure are warranted.
Identification of differentially expressed ferroptosis-related genes in abdominal aortic aneurysm: Bioinformatics analysis
Authors: Wang Kun , Song Yancheng , Li Hong , Song Jianshu , Wang Shizhong 
Published: September 2022

PurposeFerroptosis plays a crucial role in the development and progression of abdominal aortic aneurysm (AAA). The aim of this study was to identify differentially expressed genes associated with ferroptosis in AAA through bioinformatics analysis combined with experimental validation.Materials and methodsFirstly, the mRNA expression profile datasets GSE57691 and GSE47472 from Gene Expression Omnibus database were screened, and principal component analysis was carried out. Next, the R software (version 4.0.0) was used to analyze potentially differentially expressed genes associated with AAA and ferroptosis. Subsequently, protein–protein interaction analysis, gene ontology enrichment analysis, and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were performed on the selected candidate genes. Finally, quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression levels of the first five selected abnormal ferroptosis-related genes in clinical samples obtained from patients with AAA and healthy controls.ResultsBased on the information contained in the two datasets, a total of 20 differentially expressed ferroptosis-related genes (three upregulated genes and 17 downregulated genes) were selected. Protein–protein interaction analysis demonstrated interaction between these genes, while gene ontology enrichment analysis of ferroptosis genes with differential expression indicated that some enrichment items were associated with oxidative stress. The qRT-PCR results showed that the expression levels of interleukin-6 (IL-6), peroxiredoxin 1 (PRDX1), and stearoyl-CoA desaturase (SCD) were consistent with the bioinformatics prediction results obtained from the mRNA chip.ConclusionBioinformatics analysis identified 20 potential ferroptosis-related differentially expressed genes in AAA. Further verification by qRT-PCR showed that IL-6, PRXD1, and SCD might affect the process of AAA by regulating ferroptosis. Our results might assist in further understanding the pathogenesis of AAA and guiding treatment.
Seabuckthorn polysaccharide combined with astragalus polysaccharide ameliorate alcoholic fatty liver by regulating intestinal flora
Authors: Liu Jiayue , Kong Lingzhou , Shao Mengting , Sun Changhai , Li Changxu , Wang Yanyan , Chai Xue , Wang Yuliang , Zhang Yu , Li Xiaoliang , Zhao Hong 
Published: September 2022

BackgroundAt present, the incidence of alcoholic fatty liver disease (AFLD) is increasing year by year, and numerous studies have confirmed that liver diseases are closely related to intestinal flora. Seabuckthorn and Astragalus membranaceus, as traditional Chinese medicine (TCM) with the homology of medicine and food, have good liver protection, and their polysaccharides can regulate the intestinal flora. Here, we studied the effects of HRP, APS and the combination of the two polysaccharides on the intestinal flora of AFLD mice, which provided scientific basis for the treatment of AFLD with the two polysaccharides.Materials and methodsThirty Kunming (KM) mice were randomly divided into the control group (Con), the model group (Mod), the HRP treatment group (HRP), the APS treatment group (APS), and HRP+APS treatment group (HRP+APS), with six mice in each group. The AFLD model was constructed by continuous intragastric administration of 42% vol Niulanshan ethanol solution for 28 days, and the mice in each polysaccharide group were given corresponding drugs. The levels of AST, ALT, TC and TG in serum of mice were measured. 16S rRNA amplicon sequencing technique was used to determine the diversity and richness of intestinal flora, and the relative abundance of intestinal flora at phylum level and genus level of the mice in each group.ResultsHRP, APS and HRP+APS could reduce the serum levels of AST, ALT, TC and TG in mice. In addition, HRP, APS and HRP + APS restored the diversity, relative abundance and community structure of intestinal mucosa bacteria in AFLD mice to a certain extent. Specifically, HRP, APS and HRP+APS remarkably decreased the ratio of Firmicutes to Bacteroidetes, and ultimately increased the abundance of beneficial bacteria and reduced the abundance of pathogenic bacteria.ConclusionHRP, APS, and HRP+APS can improve the intestinal microecology of AFLD model mice, alleviate liver injury, and maintain normal intestinal function in different degrees.
Identification of hub genes for early detection of bone metastasis in breast cancer
Authors: Zhao Zitong , Yang Haoran , Ji Guangling , Su Shanshan , Fan Yuqi , Wang Minghao , Gu Shengli 
Published: September 2022

BackgroundGlobally, among all women, the most frequently detected and diagnosed and the most lethal type of cancer is breast cancer (BC). In particular, bone is one of the most frequent distant metastases 24in breast cancer patients and bone metastasis arises in approximately 80% of advanced patients. Thus, we need to identify and validate early detection markers that can differentiate metastasis from non-metastasis breast cancers.MethodsGSE55715, GSE103357, and GSE146661 gene expression profiling data were downloaded from the GEO database. There was 14 breast cancer with bone metastasis samples and 8 breast cancer tissue samples. GEO2R was used to screen for differentially expressed genes (DEGs). The volcano plots, Venn diagrams, and annular heatmap were generated by using the ggplot2 package. By using the cluster Profiler R package, KEGG and GO enrichment analyses of DEGs were conducted. Through PPI network construction using the STRING database, key hub genes were identified by cytoHubba. Finally, K-M survival and ROC curves were generated to validate hub gene expression.ResultsBy GO enrichment analysis, 143 DEGs were enriched in the following GO terms: extracellular structure organization, extracellular matrix organization, leukocyte migration class II protein complex, collagen tridermic protein complex, extracellular matrix structural constituent, growth factor binding, and platelet-derived growth factor binding. In the KEGG pathway enrichment analysis, DEGs were enriched in Staphylococcus aureus infection, Complement and coagulation cascades, and Asthma. By PPI network analysis, we selected the top 10 genes, including SLCO2B1, STAB1, SERPING1, HLA-DOA, AIF1, GIMAP4, C1orf162, HLA-DMB, ADAP2, and HAVCR2. By using TCGA and THPA databases, we validated 2 genes, SERPING1 and GIMAP4, that were related to the early detection of bone metastasis in BC.Conclusions2 abnormally expressed hub genes could play a pivotal role in the breast cancer with bone metastasis by affecting bone homeostasis imbalance in the bone microenvironment.