bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effectiveness of Learning With a Scientific Approach in The STAD Type Cooperative Learning Model Based on Lesson Study on Mathematics Students Learning Activities
Authors: Ginanjar Arus , Saragih Sehatta , Kartini  
Published: March 2022

This research aimed to reveal the effectiveness of learning with a scientific approach in the STAD type cooperative learning model based on lesson study on mathematics students learning activities. This is a quasi-experimental research where the population was the junior high school students in Rokan Hilir regency which divided into three school levels, namely; high level, middle level and low level. The subject of this research was chosen by applying clustering random sampling method. The second grader of each school was chosen to be the subject of this research by applying purposive sampling. There were experiment and control classes in each subject. The instruments that were used in this research, namely learning media (syllabus, lesson plan and students learning sheet activity) and for the data collection media (question sheet and observation sheet). The design of hypothesis testing of student learning activities in the form of data analysis of student learning activities through statistical tests. Statistical tests used the Kolmogorov-Smirnov data normality test, the Levene variance homogeneity test, the Mann Whitney U difference test, the Independent T-Test, the one-way ANOVA test and continued with the Scheffe test. The result of this research revealed that: students learning activities in the experiment class was better compared to the control class, for every level, there were differences of students learning activities reviewed from school level; and learning with scientific approach in STAD type cooperative learning based o lesson study was effective reviewed from students learning activities. In conclusion, it is proven that learning with a scientific approach in the STAD type cooperative learning model based on lesson study is effective to improve students’ learning activities
Kajian Intensitas Radiasi Matahari Bulanan Untuk Pemanfaatan Energi Surya di Sulawesi Tenggara
Authors: Endriatno Nanang , Sudarsono Sudarsono , Sudia Budiman , Imran Al Ichlas , Aminur Aminur , Aksar Prinob , Salimin Salimin 
Published: March 2022

Data potensi matahari dapat membantu dalam perancangan panel surya, alat pengering dan teknologi lain yang memanfaatan energi matahari. Penelitian ini bertujuan untuk mengetahui intensitas radiasi total matahari tahunan dan rata-rata tiap bulan di Provinsi Sulawesi Tenggara. Metode yang digunakan adalah pembuatan peta batas kabupaten dengan software google earth pro, kemudian berdasar peta batas tersebut dibuat peta koordinat dengan menggunakan software QGIS, kemudian memilih koordinat pada tiap kabupaten untuk menentukan intensitas radiasi matahari berdasarkan data yang diambil dari database online National Aeronautics and Space Administration (NASA). Data radiasi matahari yang diambil merupakan rata rata radiasi selama 22 tahun dari Januari sampai Desember. Lokasi yang dianalisis di Provinsi Sulawesi Tenggara yaitu; Kabupaten Buton, Buton Utara, Konawe Selatan, Konawe, Kolaka Utara, dan Kota Kendari. Hasil analisis menunjukkan intensitas radiasi matahari pada tiap Kabupaten yaitu: intensitas rata-rata tiap bulannya mempunyai pola yang berbeda, yaitu maksimum pada bulan maret yaitu 228.8 W/m2 dan oktober 274.2 W/m2 terjadi pada kabupaten Buton. Untuk nilai radiasi rata-rata maksimum 22 tahun terdapat pada Kabupaten buton yaitu 228,7 W/m2 dan minimum pada Kabupaten Kolaka Utara yaitu 207,3. W/m2. Sementara kabupaten lain, Buton Utara: 21.1 W/m2 , Konawe Selatan 221.1 W/m2, Kendari 211.8 W/m2, Konawe 207.8 W/m2, Kolaka Utara 207.3 W/m2.
Sistem Pemantauan dan Kontrol Energi Listrik Menggunakan Platform Node-RED, Influxdb dan Grafana melalui Jaringan WiFi dan Lora
Authors: Arifianto Mada Jimmy Fonda , Prasetyani Lin 
Published: March 2022

Electrical energy monitoring for home and industrial equipment plays important role to prepare the concept of green energy in the future. Usually, only one or a few energy meters are provided in each building for monitoring the energy use of the entire installation. Usually, only one or a few energy meters are provided in each building for monitoring the energy use of the entire installation. Topic of this research is developing an energy measuring instrument that is applied to every electrical equipment. Knowing the information of energy usage of each equipment in real-time is the first step in saving electricity. This help for decisions making in term of efficient utilization, for example managing the schedule of production system and preventive maintenance. The energy monitoring and controlling system proposed in this paper includes hardware development using microcontroller ESP32, LoRa module and energy sensor PZEM-004T. In addition, software development to support the system includes Node-RED as dashboard and back-end development, InfluxDB as database management and Grafana as data visualization. The prototype has been successfully made and has features according to the research objective, which is to display the electrical quantity of each tool individually and monitor it for a certain period.
PENGARUH BUDAYA ORGANISASI, SISTEM PENGENDALIAN INTERN, DAN SISTEM KEUANGAN DAERAH AKUNTANSI TERHADAP AKUNTABILITAS KINERJA INSTANSI PEMERINTAH DI KABUPATEN BOMBANA
Authors: Syahrir Muhammad , H. Hasbuddin H. Hasbuddin , Hadisantoso Erwin 
Published: March 2022

Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh budaya organisasi, sistem pengendalian intern, dan sistem akuntansi keuangan daerah terhadap akuntabilitas kinerja instansi pemerintah di Kabupaten Bombana. Responden dalam penelitian ini adalah seluruh pejabat struktural dan pejabat fungsional di Organisasi Perangkat Daerah Kabupaten Bombana. Total responden sebanyak 61 orang. Analisis data yang digunakan dalam penelitian ini adalah teknik analisis regresi linier berganda.Hasil penelitian ini menunjukkan bahwa (1) budaya organisasi berpengaruh tidak signifikan terhadap akuntabilitas kinerja instansi pemerintah, (2) sistem pengendalian intern berpengaruh signifikan terhadap akuntabilitas kinerja instansi pemerintah, (3) sistem akuntansi keuangan daerah berpengaruh signifikan terhadap akuntabilitas kinerja instansi pemerintah serta (4) budaya organisasi, sistem pengendalian intern, sistem akuntansi keuangan daerah secara simultan berpengaruh signifikan terhadap akuntabilitas kinerja instansi pemerintah. Keterbatasan Penelitian tidak memuat kecamatan dan desa sebagai subjek dalam penelitian. Pemerintah Kabupaten Bombana diharapkan untuk meningkatkan budaya organisasi secara rutin dengan mengadakan kegiatan pendidikan, pelatihan dan diklat-diklat yang berkaitan dengan kinerja karyawan dalam bertingkah laku guna meningkatkan pencapaian kinerja Kabupaten Bombana. Kata Kunci : Budaya Organisasi, Sistem Pengendalian Intern, Sistem Akuntansi Keuangan Daerah, Akuntabilitas Kinerja Instansi Pemerintah
PENGARUH PENGELUARAN PEMERINTAH, INDEKS PEMBANGUNAN MANUSIA, DAN INFLASI TERHADAP PERTUMBUHAN EKONOMI NEGARA-NEGARA ASIA TENGGARA: Suatu Pendekatan Panel ARDL
Authors: Awaluddin Awaluddin , Muthalib Abdul Azis , Suriadi La Ode 
Published: March 2022

Penelitian ini bertujuan untuk menganalisis pengaruh jangka panjang dan jangka pendek pengeluaran pemerintah, indeks pembangunan manusia, pengangguran, inflasi terhadap pertumbuhan ekonomi negara-negara Asia Tenggara. Jenis data yang digunakan dalam penelitian ini yaitu data sekunder yang diakses melalui website Theworldbank.com,, undp.org dan ceicdata.com dalam bentuk time series tahunan periode 2000 sampai 2018. Alat analsis yang digunakan yaitu Panel Auto Regressive Distributed Lag (ARDL). Hasil penelitian menunjukkan (1) Dalam jangka panjang pengeluaran pemerintah berpengaruh positif signifikan sedangkan dalam jangka pendek tidak berpengaruh signifikan terhadap pertumbuhan ekonomi negara-negara Asia Tenggara; (2) Dalam jangka panjang indeks pembangunan manusia berpengaruh positif signifikan sedangkan dalam jangka pendek tidak perpengaruh signifikan terhadap pertumbuhan ekonomi negara-negara Asia Tenggara; (3) Dalam jangka panjang inflasi berpengaruh negatif signifikan sedangkan dalam jangka pendek tidak berpengaruh signifikan terhadap pertumbuhan ekonomi negara-negara Asia Tenggara.
ANALISIS PENGELOLAAN ASET TETAP PROVINSI SULAWESI TENGGARA
Authors: Asdal Mohamad , Dali Nasrullah , Dali Nasrullah , Saranani Fajar , Saranani Fajar 
Published: March 2022

Penelitian ini bertujuan: Pengelolaan Aset Tetap Provinsi Sulawesi Tenggara. Penelitian ini menggunakan pendekatan penelitian kualitatif. informan yang telah dipilih dan dianggap memahami permasalahan penelitian Aset Tetap (Tanah) Milik Pemerintah Daerah Provinsi Sulawesi Tenggara. Analisa data dalam penelitian kualitatif, dilakukan pada saat pengumpulan data berlangsung dan setelah selesai di lapangan. Teknik analisa data yang digunakan dalam penelitian ini adalah dengan menggunakan teknik analisa data kualitatif. Hasil penelitian menunjukkan bahwa; pengelolaan inventarisasi aset yang meliputi penggunaan; pemanfaatan; pengamanan dan pemeliharaan; penilaian; penatausahaan; serta pembinaan, pengawasan dan pengendalian, dapat dikatakan bahwa kegiatan Inventarisasi dalam pengelolaan aset berupa tanah milik Pemeintah Provinsi Tenggara sudah baik, namun masih terdapat sejumlah aset yang masih dikuasai/diklaim oleh pihak lain, ini terjadi karena kurangnya pemanfaatan, pengawasan dan pengamanan dan barang milik daerah. Kata Kunci: Pengelolaan Aset Tetap
Exosomal miR-483-5p in Bone Marrow Mesenchymal Stem Cells Promotes Malignant Progression of Multiple Myeloma by Targeting TIMP2
Authors: Gu Jianmei , Wang Maoye , Wang Xinfeng , Li Jiao , Liu Haiyan , Lin Zenghua , Yang Xi , Zhang Xu , Liu Hong 
Published: March 2022

Bone marrow-derived mesenchymal stem cell (BMSC) is one crucial component of the multiple myeloma (MM) microenvironment and supports the malignant progression of MM. Whether BMSCs act on MM cells via exosomes has not been well characterized. Herein, we used microarrays to screen out differentially expressed miRNAs in BMSCs from patients with MM (MM-MSCs) or benign diseases (BD-MSCs). We found that miR-483-5p was highly expressed in MM-MSCs, which may be transported through exosomes from MM-MSCs to MM cells to increase miR-483-5p expression in them. We then investigated the role and mechanism of miR-483-5p in the aggressive progression of MM in vitro. We verified that miR-483-5p promoted MM cell proliferation and reduced apoptosis. Then we predicted and validated that TIMP2, a tumor suppressor gene, is the downstream target of miR-483-5p in MM. In summary, our study indicated that MM-MSCs promote MM malignant progression via the release of exosomes and regulation of miR-483-5p/TIMP2 axis, suggesting an essential role of BMSCs derived exosomal miRNA in MM and a potential marker for MM diagnosis and therapy.
Abnormal Glucose Metabolism Parameters and the Aggressiveness of Differentiated Thyroid Carcinoma: A Hospital-Based Cross-Section Study in China
Authors: Zhao Junyu , Tian Yutian , Jia Zhen , Yao Jinming , Liao Lin , Dong Jianjun 
Published: March 2022

PurposeThe correlation of abnormal glucose metabolism and thyroid carcinoma, especially the aggressiveness of thyroid cancer, still remains controversial. We conducted this study to investigate the relationship between abnormal glucose metabolism parameters and differentiated thyroid carcinoma (DTC) in the Chinese population.Materials and MethodsThe study was designed as a hospital-based case–control study and was approved by the Ethics Committee of our hospital and registered in the Clinical Trial Protocol Registration and Results System (Registration code: NCT 03006289). From January 1, 2018 to June 30, 2021, a total of 377 DTC patients were enrolled in the study. Demographic and general characteristics, details of thyroid surgery and histopathological results, hematological test indicators were collected. Glucose metabolism parameters were calculated. Variables were analyzed by t-test, ANOVA, chi-squared analysis and Fisher’s exact test. Pearson bi-variate correlation and Spearman’s correlation analysis were used for bi-variate analysis.ResultsMore than 40% of patients with DTC were multifocality, more than half were extra-glandular invasion, and nearly 85% complied by lymph node metastasis. The prevalence of diabetes mellitus (DM) was about 10.08% in DTC patients. It was found that the proportion of postprandial 2 h blood glucose ≥11.1mmol/L and HbA1c ≥6.5% was significantly higher than the known proportion of DM (17.8%, 16.7% vs. 10.08%). Additionally, 87.3% of the DTC patients in this study had varying degrees of insulin resistance. Further analysis found that higher T staging was associated with higher levels of area under curve of C-peptide (P = 0.029), insulin sensitivity index (P = 0.012) and C-peptide sensitivity index (P = 0.016). A delayed peak of insulin secretion was found to be positive related with capsule invasion (r = 0.206, P = 0.004). In patients without a DM history, homeostasis model assessment of insulin resistance (P = 0.017), insulin sensitivity index (P = 0.019) and C-peptide sensitivity index (P = 0.020) were statistic associated with T staging. Also, the glucose metabolism parameter at 3-hour after a meal was related to a larger number of metastatic lymph nodes.ConclusionAbnormal glucose metabolism, namely, DM, hyperinsulinemia and insulin resistance, were significantly associated with the carcinogensis and aggressiveness of DTC.
Case Report: Immune Checkpoint Inhibitors Successfully Controlled Asymptomatic Brain Metastasis in Esophageal Squamous Cell Carcinoma
Authors: Xiao Linlin , Lin Chi , Liu Yueping , Wu Yajing , Wang Jun 
Published: March 2022

BackgroundBrain metastases are the most common cause of intracranial malignancy, often resulting in significant morbidity and mortality. Brain metastases from esophageal squamous cell carcinoma (ESCC) are relatively rare, with a rate of generally less than 2%.Case ReportIn this article, we report a rare case of ESCC with asymptomatic brain metastasis. The combined positive score (CPS) of programmed cell death-ligand 1 (PD-L1) from the primary tumor was 2 by DAKO 22C3 and 3 by VENTANA SP263. The proportion of tumor infiltrating lymphocytes (TILs) was 1%. After receiving 15 cycles of immune checkpoint inhibitors (ICIs), the patient’s brain metastatic lesion had disappeared and was replaced by a local necrotic area. He retains good cognitive function with a stable disease at the primary site.ConclusionsThis is the first to be reported in an ESCC patient whose brain metastatic lesion had a complete response to ICIs, which may provide supporting data for using ICIs as an option of treatment for ESCC patients with brain metastases.
Safety and Feasibility of Esophagectomy Following Combined Immunotherapy and Chemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma: A Propensity Score Matching Analysis
Authors: Hong Zhi-Nuan , Gao Lei , Weng Kai , Huang Zhixin , Han Wu , Kang Mingqiang 
Published: March 2022

ObjectivesThe combination of neoadjuvant chemotherapy and immunotherapy (nICT) is a novel treatment for locally advanced esophageal cancer. There is concern that nICT may increase operation difficulty, postoperative morbidity, and mortality. This study aimed to compare short-term outcomes among esophagectomy after neoadjuvant chemoradiotherapy (nCRT) and nICT and for locally advanced esophageal squamous cell carcinoma (ESCC).MethodsA retrospective analysis of a prospectively maintained database was performed to identify patients (from January 2017 through July 2021) who underwent surgery for ESCC following neoadjuvant therapy. A 1:1 propensity score matching (PSM) with a caliper 0.05 was conducted to balance potential bias.ResultsA 1:1 PSM was conducted based on clinical stage, age, body mass index (BMI), and tumor location, and then 32 comparable pairs were matched. After PSM, age, gender, BMI, American Society of Anesthesiologists (ASA) status, smoking history, clinical stage, tumor location, lymphadenectomy field, pathological stage, anastomotic position, route of gastric conduit, procedure type, and operative approach were comparable between groups. Compared with the nICT group (median, 300 min), the operation time was significantly longer in the nCRT group (median, 376 min). However, both groups were comparable in intraoperative blood loss, thoracic drainage volume, intensive care unit (ICU) stay, postoperative hospital stays, and hospital cost. Further, 30-day mortality, 30-day readmission, ICU readmission, and major complications were similar in both groups. The nCRT group had an advantage in pathological response. The pathological complete response (pCR) was 18.8% (6/32) in the nICT group and 43.8% (14/32) in the nCRT group (p = 0.03). The major pathological response (MPR) was 71.9% (23/32) in the nCRT group and 34.4% (11/32) in the nICT group (p = 0.03).ConclusionsBased on our preliminary experience, esophagectomy appears to be safe and feasible following combined neoadjuvant immunotherapy with chemotherapy for locally advanced esophageal cancer.
Identification of a Novel Tumor Microenvironment Prognostic Signature for Bladder Urothelial Carcinoma
Authors: Xu Chaojie , Pei Dongchen , Liu Yi , Yu Yang , Guo Jinhua , Liu Nan , Kang Zhengjun 
Published: March 2022

BackgroundThe tumor microenvironment (TME) regulates the proliferation and metastasis of solid tumors and the effectiveness of immunotherapy against them. We investigated the prognostic role of TME-related genes based on transcriptomic data of bladder urothelial carcinoma (BLCA) and formulated a prediction model of TME-related signatures.MethodsMolecular subtypes were identified using the non-negative matrix factorization (NMF) algorithm based on TME-related genes from the TCGA database. TME-related genes with prognostic significance were screened with univariate Cox regression analysis and lasso regression. Nomogram was developed based on risk genes. Receiver operating characteristic (ROC) curve and decision curve analysis (DCA) were used for inner and outer validation of the model. Risk scores (RS) of patients were calculated and divided into high-risk group (HRG) and low-risk group (LRG) to compare the differences in clinical characteristics and PD-L1 treatment responsiveness between HRG and LRG.ResultsWe identified two molecular subtypes (C1 and C2) according to the NMF algorithm. There were significant differences in overall survival (OS) (p&lt;0.05), progression-free survival (PFS) (p&lt;0.05), and immune cell infiltration between the two subtypes. A total of eight TME-associated genes (CABP4, ZNF432, BLOC1S3, CXCL11, ANO9, OAS1, FBN2, CEMIP) with independent prognostic significance were screened to build prognostic risk models. Age (p&lt;0.001), grade (p&lt;0.001), and RS (p&lt;0.001) were independent predictors of survival in BLCA patients. The developed RS nomogram was able to predict the prognosis of BLCA patients at 1, 3, and 5 years more potentially than the models of other investigators according to ROC and DCA. RS showed significantly higher values (p = 0.047) in patients with stable disease (SD)/progressive disease (PD) compared to patients with complete response (CR)/partial response (PR).ConclusionsWe successfully clustered and constructed predictive models for TME-associated genes and helped guide immunotherapy strategies.
Sulforaphane Modulates the Inflammation and Delays Neurodegeneration on a Retinitis Pigmentosa Mice Model
Authors: Canto Antolín , Martínez-González Javier , Miranda María , Olivar Teresa , Almansa Inma , Hernández-Rabaza Vicente 
Published: March 2022

The term retinitis pigmentosa (RP) describes a large group of hereditary retinopathies. From a cellular view, retinal degeneration is prompted by an initial death of rods, followed later by cone degeneration. This cellular progressive degeneration is translated clinically in tunnel vision, which evolves to complete blindness. The mechanism underlying the photoreceptor degeneration is unknown, but several mechanisms have been pointed out as main co-stars, inflammation being one of the most relevant. Retinal inflammation is characterized by proliferation, migration, and morphological changes in glial cells, in both microglia and Müller cells, as well as the increase in the expression of inflammatory mediators. Retinal inflammation has been reported in several animal models and clinical cases of RP, but the specific role that inflammation plays in the pathology evolution remains uncertain. Sulforaphane (SFN) is an antioxidant natural compound that has shown anti-inflammatory properties, including the modulation of glial cells activation. The present work explores the effects of SFN on retinal degeneration and inflammation, analyzing the modulation of glial cells in the RP rd10 mice model. A daily dose of 20 mg/kg of sulforaphane was administered intraperitoneally to control (C57BL/6J wild type) and rd10 (Pde6brd10) mice, from postnatal day 14 to day 20. On postnatal day 21, euthanasia was performed. Histological retina samples were used to assess cellular degeneration, Müller cells, and microglia activation. SFN administration delayed the loss of photoreceptors. It also ameliorated the characteristic reactive gliosis, assessed by retinal GFAP expression. Moreover, sulforaphane treatment regulated the microglia activation state, inducing changes in the microglia morphology, migration, and expression through the retina. In addition, SFN modulated the expression of the interleukins 1β, 4, Ym1, and arginase inflammatory mediators. Surprisingly, M2 polarization marker expression was increased at P21 and was reduced by SFN treatment. To summarize, SFN administration reduced retinal neurodegeneration and modified the inflammatory profile of RP, which may contribute to the SFN neuroprotective effect.