bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formulation, nanonisation, and characterization of Polyrhachis sp. for enhanced anticancer potential: In vitro studies
Authors: Rostamizadeh Bahar , Jalalizand Alireza , Nasiri Rozita , Ghaedi Kamran 
Published: September 2022

AbstractNanotechnology is a practical and exquisite method for enhancing the bioavailability of insect medicines. The present work deals with nano‐encapsulation of freeze‐dried Polyrhachis sp. (Pol) to increase its aqueous solubility and bioactivity. In the current study, Polyrhachis sp. was encapsulated into carbonate calcium (CaCO3) through a one‐step co‐precipitation method to produce CaCO3@Pol nanoparticles (NPs). It was characterized accordingly by FTIR, FESEM, DLS, and zeta potential analysis methods. Null CaCO3 and CaCO3@Pol particle sizes were observed in the nano range, and most of the nanoparticles had spherical shapes. The cytotoxicity evaluation of neat Pol and CaCO3@Pol was performed in vitro on human breast cancer cells (MCF7) and human gastric cancer cells (AGS) through an MTT assay. Morphological alternation studies disclosed that CaCO3@Pol‐treated cells had undergone apoptosis since shrinkage and apoptotic bodies were observed. The half‐maximal inhibitory and 50% lethal dose of neat Pol and CaCO3@Pol were calculated. Besides, the RT‐PCR technique analyzed the status of apoptosis genes such as caspase‐3, caspase‐8, caspase‐9, Bcl‐2, and Bax expressions. The molecular mechanisms provoked apoptosis through modulating pro (caspase‐8, caspase‐9, Bax) and anti‐apoptotic (Bcl‐2) mediator genes expression in AGS cells. The findings conveyed that the CaCO3@Pol is a promising biomaterial for future biomedical applications.
Two‐dimensional ultrasonography and CEUS of a case with primary biliary cholangitis and vanishing bile duct syndrome
Authors: Yu Pengzhi , Zhou Yonghe , Li Xin 
Published: September 2022

AbstractVanishing bile duct syndrome (VBDS) is a pathological concept that refers to the gradual reduction, destruction and disappearance of intrahepatic bile ducts caused by drugs, immunity, malignancy, and infections (including HIV and tuberculosis). Its clinical manifestation is cholestasis. The pathological diagnostic criteria for VBDS are the occurrence of intralobular vanishing bile ducts in more than 50% of 10 or more portal areas. At present, the diagnosis of VBDS still relies on liver biopsy. Contrast‐enhanced ultrasound has been widely used in the diagnosis of liver‐related diseases. The intravenous injection of microbubbles could enhance the observation of tissue microcirculation and significantly expand the possibility of ultrasound hemodynamic research. VBDS is a rare disease, and there are few reports on the early ultrasound and CEUS manifestations. The purpose of this report is to explore the unique performance of ultrasound and CEUS in the diagnosis of VBDS.
Genome‐wide comparison of DNA methylation patterns between yak and three cattle strains and their potential association with mRNA transcription
Authors: Xin Jin‐Wei , Chai Zhi‐Xin , Jiang Hui , Cao Han‐Wen , Chen Xiao‐Ying , Zhang Cheng‐Fu , Zhu Yong , Zhang Qiang , Ji Qiu‐Mei 
Published: September 2022

AbstractYak has evolved specific adaptative mechanisms to high‐altitude environment. Up to date, only a few studies reported the DNA methylation in yak. In the present study, genome‐wide DNA methylome and transcriptome profiles in lung, mammary, and biceps brachii muscle tissues were compared between yak and three cattle breeds (Tibetan cattle, Sanjiang cattle, and Holstein cattle). The association between differentially expressed genes (DEGs) and differentially methylated regions (DMRs) was analyzed, and the biological functions of DEGs potentially driven by DMRs were explored by KEGG enrichment analysis. Finally, we found that yak‐specific DMRs‐driven DEGs were mainly involved in neuromodulation, respiration, lung development, blood pressure regulation, cardiovascular protection, energy metabolism, DNA repair, and immune functions. The higher levels of the key genes associated with these functions were observed in yak than in cattle, suggesting that DNA methylation might regulate these genes. Overall, the present study contributes basic data at the DNA methylation level to further understand the physiological metabolism in yak.
Endoscopic hemostasis using gel immersion endoscopy for duodenal ulcer and a sigmoid colon polyp: A novel gel injection method
Authors: Jinushi Ryuhei , Tashima Tomoaki , Ishii Naoki , Fujita Akashi , Tanisaka Yuki , Mizuide Masafumi , Mashimo Yumi , Kawasaki Tomonori , Ryozawa Shomei 
Published: September 2022

AbstractGel immersion endoscopy (GIE) has gained prominence for securing a good visual field. Traditionally, OS‐1 jelly (Otsuka Pharmaceutical Factory) has been used for GIE. However, due to the presence of electrolytes, it is unsuitable for endoscopic hemostasis using a monopolar device. Therefore, VISCOCLEAR (Otsuka Pharmaceutical Factory), a new gel that does not contain electrolytes, has been developed. Moreover, unlike water or saline, VISCOCLEAR does not readily mix with blood, making it effective in visualizing gastrointestinal bleeding. We report two cases in which GIE was performed using a novel gel injection method.
X‐ray exposure in cryoballoon versus radiofrequency ablation for atrial fibrillation over 7 years: A single center study
Authors: Heinroth Konstantin , Blum Tilman , Drexler Max , Plehn Alexander , Hartkopf Thomas , Horenburg Charlotte , Sedding Daniel 
Published: September 2022

AbstractBackgroundFacing an increasing number of radiofrequency ablation (RF) and cryoballoon ablation (CB) procedures for treatment of AF radiation exposure and its reduction is a focus point for interventional electrophysiologists.ObjectiveThis study evaluated the procedural parameters of the different ablation methods focusing on radiation exposure and the BMI of the patients.MethodsOne thousand one hundred and thirty‐three first procedural cases of pulmonary vein isolation in patients with paroxysmal and persistent AF treated with RF and CB‐based techniques were analyzed retrospectively over a period of 7 years focusing on the endpoints dose area product (DAP, cGycm2), fluoroscopy time (FT, min) and procedural time (PT, min).ResultsOf the 1133 patients (mean age 63.4 ± 11.4 years, BMI 28.9 ± 4.7) 335 patients received an RF procedure, 211 patients were treated with the cryoballoon first generation (CB1), and 587 patients with cryoballoon second generation (CB2), respectively. The mean DAP for the PVI was 508 ± 654 cGycm2 in RF procedures, 1077 ± 683 cGycm2 in CB1‐procedures, and 587 ± 489 cGycm2 in CB2‐procedures with fluoroscopy times significantly shorter in RF procedures (9.6 ± 5.2 min) as compared to 17.7 ± 5.9 min in CB1‐ and 16.3 ± 6.3 min in CB2‐procedures (p < .001). At the same time, the procedure duration using RF (115 ± 33.5 min) was significantly longer than both in CB1 (96 ± 16.8 min) and CB2 procedures (75 ± 15.9 min).ConclusionsDespite longer fluoroscopy durations in the CB technique, the CB2 resulted in a comparable low radiation exposure in PVI as compared to RF, accompanied by shorter procedure durations.
Worldwide research trends on Neanderthals
Authors: Guil‐Guerrero José Luis , Manzano‐Agugliaro Francisco 
Published: September 2022

AbstractResearch on Neanderthals is a topic of growing interest and it may even be considered that this subject will get more attention in the future. The demise and diets of the various Neanderthal populations are controversial issues that promote heated debates. In this work, a bibliometric study of all the publications contained in the Scopus database until 2021 has been conducted, analysing more than 3800 of them. The main authors, institutions and countries researching this subject have been identified, and their future development. Furthermore, the links between the authors, the countries and the topics researched have been analysed through communities detection. The most frequent keyword on this topic is ‘fossil’. Three clearly focused research clusters in this area have been detected: those focused on molecular evolution, those focused on Neanderthal biology, and those focused on palaeoanthropology. Furthermore, it has been noted that the most central countries to the networks of collaboration are the United States, Spain, France and Germany. Research on Neanderthals is in its infancy and the appearance of new clusters is expected, such as those related to the diet and the demise of Neanderthals, considering the growing number of works recently developed on these topics.
LINC00960 regulates cell proliferation and glycolysis in pancreatic cancer through the miR‐326‐3p/TUFT1/AKT–mTOR axis
Authors: Zhou Bin , Lei Jing‐Hao , Wang Qiang , Qu Teng‐Fei , Cha Li‐Chao , Zhan Han‐Xiang , Liu Shang‐Long , Hu Xiao , Sun Chuan‐Dong , Cao Jing‐Yu , Qiu Fa‐Bo , Guo Wei‐Dong 
Published: September 2022

AbstractPancreatic cancer (PC) is a common malignant cancer characterized by high mortality and poor prognosis. LINC00690 was involved in the occurrence and progression of PC, but the underlying mechanisms require further investigation. The goal of this study was to figure out how LINC00960 mediates glycolysis in PC. LINC00960, miR‐326‐3p, and Tuftelin 1 (TUFT1) expression levels were detected in PC cell lines. LINC00960 and TUFT1 expression levels were increased in PC cells when compared with normal pancreatic cells, whereas miR‐326‐3p expression levels were decreased. The expression levels of LINC00690 affected glycolysis in PC, and inhibition of LINC00960 inhibited tumor growth in vivo. LINC00690 targeted and suppressed the expression of miR‐326‐3p. MiR‐326‐3p bound to TUFT1, and miR‐326‐3p inhibited AKT–mTOR pathway activation via TUFT1. In conclusion, the depletion of LINC00960 repressed cell proliferation and glycolysis in PC by mediating the miR‐326‐3p/TUFT1/AKT–mTOR axis. Thus, we present a novel mechanism underlying the progression of PC that suggests LINC00960 is a potential therapeutic target for this cancer.
Interactive effects of temperature and nitrogen source on the elemental stoichiometry of a polar diatom
Authors: Schiffrine Nicolas , Tremblay Jean‐Éric , Babin Marcel 
Published: September 2022

AbstractA recent study hypothesized that the near‐zero temperatures that generally prevail in Arctic waters negate the influence that different nitrogen (N) sources can otherwise have on the growth and elemental stoichiometry of marine micro‐algae. Here we test this hypothesis experimentally by evaluating how temperature (0–9°C) affects the growth and elemental stoichiometry of an ecologically relevant Arctic diatom Chaetoceros gelidus growing on different N sources (ammonium, nitrate, urea) at saturating irradiance. Following an initial acclimation period in which steady growth rates were achieved under each experimental treatment, changes in cellular concentrations of chlorophyll a and particulate carbon (C), nitrogen (N), phosphorus (P), and biogenic silica (Si) were monitored. While N source effects on growth rate became manifest as temperature rose above 0°C, the estimated optimal growth temperature was similar in all cases (Topt = 8.3°C). A positive effect of temperature on the N : P ratio occurred only at 6°C. Above this temperature, the N : P ratio decreased to values close to those observed at 0°C and 3°C. By contrast, the C : N ratio remained nearly invariant between 0°C and 6°C but increased substantially at 9°C. Overall, the results suggest that the presently widespread and successful diatom C. gelidus possesses the ability to remain competitive despite ongoing environmental changes and that its responses to warming and the availability of different N sources may impact elemental fluxes in the future.
Multi‐Interfaces Regulated Polyaniline/Nano‐Fe3O4/Graphene Ternary Hybrids for Ultra‐Broadband Electromagnetic Absorption
Authors: Song Xiaolong , Chen Xiangnan , Gou Guangjun , Xu Hairui , Zhang Zhiyong , Cui Liying , Peng Tianxiang , Zhu Shibu 
Published: September 2022

AbstractGraphene‐based electromagnetic absorbing materials have attracted growing attention, due to their great absorption efficiency and light weight. One common design principle is to load magnetic particles onto graphene. However, the agglomeration of magnetic nanoparticles on the graphene sheets limits further improvement in their electromagnetic absorption performances. In this work, polyaniline/nano‐Fe3O4/graphene ternary hybrids with regulated multi‐interfaces are designed by simply adjusting the adding order of graphene. The dispersion of nano‐Fe3O4 on graphene and the interactions among the ternary interfaces are synchronously controlled, which are considered to be the key factors restricting the hybrids’ performances. The polyaniline/nano‐Fe3O4/graphene ternary composites show ultra‐broadband electromagnetic absorption, with the optimal reflection loss peak reaching −57.2 dB at 11.4 GHz, and the effective bandwidth achieves 13.2 GHz, covering 4.8–18 GHz. It is found that the well dispersion of nano‐Fe3O4 can enhance the overall ferromagnetism and magnetic losses, while the modulation of the multi‐interfaces can further ameliorate the interfacial and dipole polarization, synergistically making the ultra‐broadband electromagnetic absorption. This work provides areferencing path for the design of subsequent multi‐interfacing electromagnetic absorbing materials.
How songs from growing up and viewers' attachment styles affect video ads' effectiveness
Authors: Lourenço Carlos J. S. , Isabella Giuliana , Verbeke Willem , Vo Khoi , Dimoka Angelika , Bagozzi Richard P. 
Published: September 2022

AbstractWe propose that the positive effect of coming‐of‐age songs on ad effectiveness arises from a mediation process where the music‐evoked interpersonal memories of growing up stored in the brain and their accompanying emotions inevitably play a role, but not so straightforwardly as previously suggested. Rather, their effects work through the heightened familiarity of and peaked preferences for coming‐of‐age songs. We also propose that these sequentially mediated effects are moderated by viewers' developmental attachment styles. We test and find support for these propositions in three multimethod studies with more than 1200 participants born between the 40s and the mid‐70s and almost 60 popular songs released between the 60s and the 2010s. We discuss the implications of our findings, namely for age‐segmented video ads, and suggest future research directions.
Diagnostic evaluation of extreme winter rainfall events over the Arabian Peninsula using high‐resolution weather research and forecasting simulations
Authors: Attada Raju , Dasari Hari Prasad , Ghostine Rabih , Kondapalli Niranjan Kumar , Kunchala Ravi Kumar , Luong Thang M. , Hoteit Ibrahim 
Published: September 2022

AbstractThe sensitivity of different cumulus physical parameterization schemes for simulating extreme winter precipitation events over the Arabian Peninsula (AP) is investigated using a high‐resolution weather research and forecasting (WRF) model. For winters in 2001–2016, the following three parameterization schemes are examined: (i) Kain–Fritsch (KF), (ii) Betts–Miller–Janjić (BMJ), and (iii) Grell–Freitas (GF). The simulation results suggest that the AP extreme winter rainfall events are best simulated using the KF, followed by the BMJ, in terms of spatial distribution and intensity. The spatial pattern correlation coefficient between the model‐simulated and observed rainfall is highest with KF (0.94), followed by BMJ (0.91) and GF (0.76). These results are attributed to a better representation of the moisture transport associated with upper‐tropospheric cyclonic circulation and potential vorticity intrusions. By contrast, the GF scheme fails to simulate moisture convergence and updrafts, leading to an unrealistic representation of cloud hydrometeors and an improper organization of convection and associated extreme rainfall intensities. Meanwhile, the KF and BMJ also successfully simulate the dynamics and thermodynamics of extreme rainfall events that are usually driven by synoptic forcing. The study results suggest that the choice of cumulus parameterization schemes in the WRF model is critical for reliable simulation of extreme rainfall in the hyperarid AP region.
Considering passenger pigeon abundance and distribution in the Late Woodland zooarchaeological record of southern Ontario, Canada
Authors: Orchard Trevor J. , Needs‐Howarth Suzanne , Hawkins Alicia L. , Lesage Louis , Guiry Eric J. , Royle Thomas C. A. 
Published: September 2022

AbstractThe passenger pigeon (Ectopistes migratorius) was once the most abundant bird species in North America. Flocks of these birds witnessed in the early 19th century were so vast that they were said to darken the sky for days as they passed. Early syntheses of passenger pigeon remains in archaeological contexts in the eastern United States, in contrast, found them to be relatively rare in relation to other fowl, leading to the suggestion that the colonial‐era hyper‐abundance of passenger pigeons was a post‐European‐contact phenomenon resulting from contact‐induced demographic and ecological changes. In this paper, we provide new insights into passenger pigeon historical ecology through a synthesis and GIS‐based analysis of zooarchaeological data on skeletal remains from 157 Late Woodland (ca. 900–1650 CE) sites in Ontario, Canada. Our results reveal that passenger pigeon bones are common, and often abundant, in Late Woodland archaeological assemblages in Ontario, which speaks to the species' importance to Indigenous peoples in the region. However, the relative abundance of passenger pigeon remains varies over time, suggesting longer‐term trends in their availability and/or in hunting patterns.
Association between weight‐loss history and weight loss achieved in clinical obesity management: Retrospective chart review
Authors: Kuk Jennifer L. , Kamran Elham , Wharton Sean 
Published: September 2022

AbstractObjectiveWeight history and its association with the weight loss achieved in a publicly funded clinical obesity management program were examined in 9348 patients.MethodsWeight history (frequency and magnitude of weight losses) was collected through questionnaires at enrollment, and weight change was assessed with retrospective electronic medical chart review.ResultsThe majority of patients reported developing overweight prior to the age of 40 years and having lost at least 4.5 kg (10 lb) of weight at least once in their lifetime. Those who had an earlier onset of overweight had a higher frequency of past weight loss and had more cumulative weight loss over their lifetime. In women, but not men, earlier age of overweight onset and lifetime weight loss were associated with modestly greater weight loss at the clinic.ConclusionsWomen with greater weight‐loss history also have modestly greater weight loss at the obesity management clinic. Thus, successful long‐term obesity management, particularly for women, may include a series of repeated attempts at weight loss that should not be viewed as failures but could be viewed instead as practice.
When lightning strikes twice: Perceptions of oncology social workers about working with families with two members in treatment
Authors: Barnhart Meredith , Berkman Cathy , Mapp Susan C. 
Published: September 2022

AbstractObjectiveFamilies with a parent and child concurrently receiving cancer treatment are not common, but their needs are typically more complex than families with only one member in treatment. They have a heightened sense of loss, vulnerability, and mortality. The study purpose was to: (1) describe quality of life, social support, resiliency, and loss for these families; and (2) describe how healthcare teams can support these families.MethodsThis was a qualitative study with 20 oncology social workers who had worked with families with a parent and child concurrently receiving treatment for cancer within the past five years. The interview included questions about the emotional, social, financial, and other needs of these families, as well as their social support, quality of life, loss, and resiliency.ResultsThree themes emerged from the data: 1. Increased demands on the family with a concurrent cancer treatment, including emotional, financial, and logistical challenges for the ill parent and child and for the healthy parent and siblings; 2. Greater resilience and coping skills were experienced by some families; and 3. Implications for the healthcare team, including emotional distress in treating these families, challenges in treatment adherence, and providing the necessary support to these families.ConclusionSupporting these families is challenging for social workers and other members of the healthcare team. Understanding the emotional, financial and logistical needs of these families, and coordinating their care across the adult and pediatric teams, will better support the patients, as well as the healthcare providers who work with them.
Synthesis, Characterization and UV‐Crosslinking of Aromatic (Co)polycarbonates Bearing Pendant Azido Groups
Authors: Nagane Samadhan S. , Kuhire Sachin S. , Ichake Amol B. , Talanikar Aniket A. , Lochab Bimlesh , Wadgaonkar Prakash P. 
Published: September 2022

AbstractA new series of (co)polycarbonates bearing pendent azido groups was synthesized by polycondensation of varying molar proportions of 4, 4’‐(5‐azidopentane‐2, 2‐diyl) diphenol and bisphenol‐A with triphosgene. The chemical structures, compositions and random nature of (co)polycarbonates were confirmed by NMR spectroscopy. Inherent viscosities and number‐average molecular weights of (co)polycarbonates were in the range 0.63–0.77 dL g−1 and 35,400–43,400 g mol−1, respectively indicating the formation of reasonably high molecular weight polymers. (Co)polycarbonates could be cast into tough, transparent and flexible films from chloroform solutions. (Co)polycarbonates were further characterized using IR spectroscopy, XRD, TGA and DSC. The thermal crosslinking of (co)polycarbonates bearing pendant azido groups was studied by DSC analysis. Independently, (co)polycarbonates bearing pendant azido groups were exposed to UV irradiation at wavelength of 254 nm and decomposition reaction of azido groups was monitored by FT‐IR spectroscopy. The complete decomposition of azido groups was observed with exposure time of 30 min. The formed cross‐linked (co)polycarbonates exhibited improved % char yield values compared to parent (co)polycarbonates. The measurement of mechanical properties of representative crosslinked (co)polycarbonates indicated increase in tensile strength and Young's modulus and decrease in % elongation compared to corresponding parent linear (co)polycarbonates.
Optimization of Evaporative Light Scattering Detector using Response Surface Methodology for Liquid Chromatography Analysis of Frondoside A
Authors: Tasfiyati Aprilia Nur , Prasetia Hafiizh , Muzdalifah Dian , Ramadhaningtyas Dillani Putri , Andreas Andreas , Yuliani Fitri , Majalis Asep Nurohmat , Ernawati Teni 
Published: September 2022

AbstractResponse surface methodology is employed to investigate the optimum evaporative light scattering detector (ELSD) operating conditions for high performance liquid chromatography (HPLC) analysis of frondoside A, which is a bioactive compound valuable for its anti‐cancer activity. The results suggest that ELSD response is mostly affected by nebulizing gas flow rate and evaporator temperature. The optimum response of frondoside A is achieved by adjusting ELSD evaporator and nebulizer temperature at 80 °C and 35 °C, respectively, with nebulizing gas flow rate of 0.9 SLM. The analysis of variance (ANOVA) test results demonstrated that the established model can successfully describe the relationship between the signal response and ELSD experimental parameters, and predict the optimum ELSD parameters for frondoside A analysis. Furthermore, analytical method validation performed in optimum conditions shows that the proposed method also exhibits adequate sensitivity and linearity, with acceptable precision and accuracy. The results demonstrate the suitability of HPLC‐ELSD technique for the development of routine analysis procedures of frondoside A in natural product samples.