bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial
Authors: Hadanny Amir , Catalogna Merav , Yaniv Slava , Stolar Orit , Rothstein Lynn , Shabi Adi , Suzin Gil , Sasson Efrat , Lang Erez , Finci Shachar , Polak Nir , Fishlev Gregory , Harpaz Ruth Tock , Adler Moran , Goldman Ron-El , Zemel Yonatan , Bechor Yair , Efrati Shai 
Published: September 2022

AbstractPersistent post-concussion syndrome (PPCS) is a common and significant morbidity among children following traumatic brain injury (TBI) and the evidence for effective PPCS treatments remains limited. Recent studies have shown the beneficial effects of hyperbaric oxygen therapy (HBOT) in PPCS adult patients. This randomized, sham-control, double blind trial evaluated the effect of hyperbaric oxygen therapy (HBOT) on children (age 8–15) suffering from PPCS from mild-moderate TBI events six months to 10 years prior. Twenty-five children were randomized to receive 60 daily sessions of HBOT (n = 15) or sham (n = 10) treatments. Following HBOT, there was a significant increase in cognitive function including the general cognitive score (d = 0.598, p = 0.01), memory (d = 0.480, p = 0.02), executive function (d = 0.739, p = 0.003), PPCS symptoms including emotional score (p = 0.04, d = – 0.676), behavioral symptoms including hyperactivity (d = 0.244, p = 0.03), global executive composite score (d = 0.528, p = 0.001), planning/organizing score (d = 1.09, p = 0.007). Clinical outcomes correlated with significant improvements in brain MRI microstructural changes in the insula, supramarginal, lingual, inferior frontal and fusiform gyri. The study suggests that HBOT improves both cognitive and behavioral function, PPCS symptoms, and quality of life in pediatric PPCS patients at the chronic stage, even years after injury. Additional data is needed to optimize the protocol and to characterize the children who can benefit the most.
MHD mixed convective stagnation point flow of nanofluid past a permeable stretching sheet with nanoparticles aggregation and thermal stratification
Authors: Mahmood Zafar , Alhazmi Sharifah E. , Alhowaity Awatif , Marzouki Riadh , Al-Ansari Nadir , Khan Umar 
Published: September 2022

AbstractUsing a thermally stratified water-based nanofluid and a permeable stretching sheet as a simulation environment, this research examines the impact of nanoparticle aggregation on MHD mixed convective stagnation point flow. Nanoparticle aggregation is studied using two modified models: the Krieger–Dougherty and the Maxwell–Bruggeman. The present problem's governing equations were transformed into a solvable mathematical model utilizing legitimate similarity transformations, and numerical solutions were then achieved using shooting with Runge–Kutta Fehlberg (RKF) technique in Mathematica. Equilibrium point flow toward permeable stretching surface is important for the extrusion process because it produces required heat and mass transfer patterns and identifies and clarifies fragmented flow phenomena using diagrams. Nanoparticle volume fraction was shown to have an impact on the solutions' existence range, as well. Alumina and copper nanofluids have better heat transfer properties than regular fluids. The skin friction coefficients and Nusselt number, velocity, temperature profiles for many values of the different parameters were obtained. In addition, the solutions were shown in graphs and tables, and they were explained in detail. A comparison of the current study's results with previous results for a specific instance is undertaken to verify the findings, and excellent agreement between them is observed.
Incidence and mortality rates of strokes in Kazakhstan in 2014–2019
Authors: Zhakhina Gulnur , Zhalmagambetov Bakhytbek , Gusmanov Arnur , Sakko Yesbolat , Yerdessov Sauran , Matmusaeva Elzar , Imanova Aliya , Crape Byron , Sarria-Santamera Antonio , Gaipov Abduzhappar 
Published: September 2022

AbstractThere is a lack of information on the epidemiology of acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH) in developing countries. This research presents incidence and mortality rates of stroke patients based on hospital admission and discharge status in one of the Central Asian countries by analysis of large-scale healthcare data. The registry data of 177,947 patients admitted to the hospital with the diagnosis of stroke between 2014 and 2019 were extracted from the National Electronic Health System of Kazakhstan. We provide descriptive statistics and analyze the association of socio-demographic and medical characteristics such as comorbidities and surgical treatments. Among all stroke patients, the incidence rate based on hospital admission of AIS was significantly higher compared to SAH and ICH patients. In 5 year follow-up period, AIS patients had a better outcome than SAH and ICH patients (64.7, 63.1 and 57.3% respectively). The hazard ratio (HR) after the trepanation and decompression surgery was 2.3 and 1.48 for AIS and SAH patients; however, it was protective for ICH (HR = 0.87). The investigation evaluated an increase in the all-cause mortality rates based on the discharge status of stroke patients, while the incidence rate decreased over time.
Combined toxicities of cadmium and five agrochemicals to the larval zebrafish (Danio rerio)
Authors: Hu Guixian , Wang Hao , Wan Yujie , Zhou Liangliang , Wang Qiang , Wang Minghua 
Published: September 2022

AbstractDifferent pollutants usually co-exist in the natural environment, and the ecological and health risk assessment of agrochemicals needs to be carried out based on the combined toxicological effects of pollutants. To examine the combined toxicity to aquatic organisms, the effects of cadmium (Cd) and five pesticides (acetamiprid, carbendazim, azoxystrobin, chlorpyrifos, and bifenthrin) mixture on zebrafish (Danio rerio) larvae were assessed. The data from the 96-h toxicity test indicated that bifenthrin possessed the highest toxicity to D. rerio with the LC50 value of 0.15 mg L−1, followed by chlorpyrifos (0.36 mg L−1) and azoxystrobin (0.63 mg L−1). Cd (6.84 mg L−1) and carbendazim (8.53 mg L−1) induced the intermediate toxic responses, while acetamiprid (58.39 mg L−1) presented the lowest toxicity to the organisms. Pesticide mixtures containing chlorpyrifos and bifenthrin or acetamiprid and carbendazim showed synergistic impacts on the zebrafish. Besides, two binary combinations of Cd-acetamiprid and Cd-chlorpyrifos also displayed a synergistic effect on D. rerio. Our results offered a better idea of the mixed ecological risk assessment of Cd and different agricultural chemicals to aquatic organisms. Our findings better interpreted how the interaction between Cd and various agrochemicals changed their toxicity to aquatic vertebrates and provided valuable insights into critical impacts on the ecological hazard of their combinations.
Inactivation of SARS-CoV-2 and photocatalytic degradation by TiO2 photocatalyst coatings
Authors: Lu Yun , Guan Sujun , Hao Liang , Yoshida Hiroyuki , Nakada Shohei , Takisawa Taisei , Itoi Takaomi 
Published: September 2022

AbstractThe novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causative agent of the COVID-19, which is a global pandemic, has infected more than 552 million people, and killed more than 6.3 million people. SARS-CoV-2 can be transmitted through airborne route in addition to direct contact and droplet modes, the development of disinfectants that can be applied in working spaces without evacuating people is urgently needed. TiO2 is well known with some features of the purification, antibacterial/sterilization, making it could be developed disinfectants that can be applied in working spaces without evacuating people. Facing the severe epidemic, we expect to fully expand the application of our proposed effective approach of mechanical coating technique (MCT), which can be prepared on a large-scale fabrication of an easy-to-use TiO2/Ti photocatalyst coating, with hope to curb the epidemic. The photocatalytic inactivation of SARS-CoV-2 and influenza virus, and the photocatalytic degradation of acetaldehyde (C2H4O) and formaldehyde (CH2O) has been investigated. XRD and SEM results show that anatase TiO2 successfully coats on the surface of Ti coatings, while the crystal structure of anatase TiO2 can be increased during the following oxidation in air. The catalytic activity towards methylene blue of TiO2/Ti coating balls has been significantly enhanced by the followed oxidation in air, showing a very satisfying photocatalytic degradation of C2H4O and CH2O. Notably, the TiO2/Ti photocatalyst coating balls demonstrate a significant antiviral activity, with a decrease rate of virus reached 99.96% for influenza virus and 99.99% for SARS-CoV-2.
Integrated acoustic resonators in commercial fin field-effect transistor technology
Authors: Anderson Jackson , He Yanbo , Bahr Bichoy , Weinstein Dana 
Published: September 2022

AbstractIn radio communication, the growth of beamforming and multiple-input–multiple-output technologies, which increase transceiver complexity, have led to a drive to reduce the size, weight and power of radio components by integrating them into a single system on chip. One approach is to integrate the frequency references of acoustic microelectromechanical systems (MEMS) with complementary metal–oxide–semiconductor processes, typically through a MEMS-first or MEMS-last approach that requires process customization. Here we report unreleased acoustic resonators that are fabricated in 14 nm fin field-effect transistor technology and operate in the X-band frequency range (8–12 GHz). The devices use phononic waveguides for acoustic confinement and exploit metal–oxide–semiconductor capacitors and transistors to electromechanically drive and sense acoustic vibrations. Fifteen device variations are analysed across 30 bias points, quantifying the importance of phononic confinement on resonator performance and demonstrating the velocity-saturated piezoresistive effect in active resonant transistors. Our results illustrate the feasibility of integrating acoustic devices directly into standard complementary metal–oxide–semiconductor processes.
Transcriptomic plasticity of the hypothalamic osmoregulatory control centre of the Arabian dromedary camel
Authors: Lin Panjiao , Gillard Benjamin T. , Pauža Audrys G. , Iraizoz Fernando A. , Ali Mahmoud A. , Mecawi Andre S. , Alim Fatma Z. Djazouli , Romanova Elena V. , Burger Pamela A. , Greenwood Michael P. , Adem Abdu , Murphy David 
Published: September 2022

AbstractWater conservation is vital for life in the desert. The dromedary camel (Camelus dromedarius) produces low volumes of highly concentrated urine, more so when water is scarce, to conserve body water. Two hormones, arginine vasopressin and oxytocin, both produced in the supraoptic nucleus, the core hypothalamic osmoregulatory control centre, are vital for this adaptive process, but the mechanisms that enable the camel supraoptic nucleus to cope with osmotic stress are not known. To investigate the central control of water homeostasis in the camel, we first build three dimensional models of the camel supraoptic nucleus based on the expression of the vasopressin and oxytocin mRNAs in order to facilitate sampling. We then compare the transcriptomes of the supraoptic nucleus under control and water deprived conditions and identified genes that change in expression due to hyperosmotic stress. By comparing camel and rat datasets, we have identified common elements of the water deprivation transcriptomic response network, as well as elements, such as extracellular matrix remodelling and upregulation of angiotensinogen expression, that appear to be unique to the dromedary camel and that may be essential adaptations necessary for life in the desert.
Novel pyroptosis-associated genes signature for predicting the prognosis of sarcoma and validation
Authors: Wen Hao , Guo Dandan , Zhao Zhenguo , Xin Xin , Shi Qi , Cao Jiachen , Song Lingxie , Jiang Yuliang , Liu Chunxia , Li Feng 
Published: September 2022

Abstract
Background: Sarcoma is a rare mesenchymal malignant tumor. Recently, pyroptosis has been reported to be a mode of programmed cell death. Nonetheless, levels of pyroptosis-associated genes in sarcoma and its relevance to prognostic outcomes are yet to be elucidated. Results: Sarcoma cases were classified into two subtypes with regards to differentially expressed genes. We established a profile composed of seven genes and classified the sarcoma patients into low- and high-risk groups through least absolute shrinkage and selection operator Cox regression. Survival rate of low-risk sarcoma patients was markedly higher, relative to high-risk group (P&lt;0.001). In combination with clinical features, the risk score was established to be an independent predictive factor for OS of sarcoma patients. Chemotherapeutic drug sensitivity response analysis found 65 drugs with higher drug sensitivity in low-risk, than in high-risk group and 14 drugs with higher drug sensitivity in the high-risk patient group, compared with low-risk patient group. In addition, functional enrichment, pathway and gene mutation of the two modules were analyzed. Finally, we used qRT-PCR to detect the expression of seven pyroptosis-related genes in tumor cells, and human skeletal muscle cells, compared with human skeletal muscle cells, PODXL2, LRRC17, GABRA3, SCUBE3 and RFLNB genes show high expression levels in tumor cells, while IGHG2 and hepatic leukemia factor show low expression levels in tumor cells. Conclusions: Our research suggest that pyroptosis is closely associated with sarcoma, and these findings confirm that pyroptosis-associated seven genes have a critical role in sarcoma and are potential prognostic factors for sarcoma.
Performance analysis of energy efficient improved LEACH protocol in IoT networks
Authors: Bhatia Surbhi , Kumar Ankit , Kumar Adarsh , Alshuhail Asma Shuhail 
Published: September 2022

AbstractThe Internet of Things incorporates embedded technologies, wireless sensor networks, control and automation technologies, and wearable devices to enable integrated buildings, enterprises, intelligent homes, and wearable devices. Because sensor nodes have limited power, the energy consumption of the Internet of Things network is critical. Low‐energy adaptive clustering hierarchy is a green protocol that divides the network into clusters of a fixed size. Cluster heads are assigned to each cluster so that information can be relayed to the base station. This protocol is a dynamic clustering protocol that changes cluster heads after each round within the community. The cluster heads are chosen in the network entirely based on the energy of each node and the distance between the sensor node and the base station. When sensor nodes aggregate data to the cluster head, energy is also consumed. The work proposed in this paper reduces wireless sensor network energy consumption by improving proposed protocol. The cache nodes combine data from the cluster heads node and send the extra data to the base station. The results show that the proposed work reduces the number of dead nodes in the network by 83 percent and increases the node energy level by 1.66 times.
An application of four‐wire grid‐forming power inverter in unbalanced distribution network
Authors: Döhler Jéssica S. , Mota Raul P. , Archetti João Antônio G. , Júnior Dalmo C. Silva , Boström Cecilia , Oliveira Janaína G. 
Published: September 2022

AbstractThe modelling of a three‐phase four‐leg four‐wire grid‐forming inverter in a low voltage distribution system 18‐bus European Cigré under unbalanced conditions in an autonomous distribution network is presented. The case study has two types of inverters control strategy: (i) grid‐forming to supply all the system demand in the interval of the intentional supply interruption and (ii) grid‐following to integrate photovoltaic renewable energy resources into power systems. The model suggests a control scheme with two loops: An inner current loop with a proportional‐integral controller and an outer voltage loop with a proportional controller, both in the synchronous reference frame (dq0), in which dq‐axis are decomposed in positive and negative sequences. Simulation results, carried out using the PSCAD software, showed the effectiveness of the suggested control strategy with smooth synchronization where the grid‐forming inverter was able to form a network with an unbalanced degree lower than 2%, sinusoidal voltage and frequency within standard limits 49.5–50.5 Hz.
Online correction method of IGBT lifetime evaluation based on bonding wire failure monitoring
Authors: Lei Qi , Luchun Du , Xiangyu Zhang , Wuyu Zhang , Hong Shen 
Published: September 2022

AbstractInsulated gate bipolar transistor (IGBT) modules are widely used as power switching devices. In actual working conditions, the failure of bonding wires is one of the most important failure modes. At present, the influence of bonding wire failure is not considered in the reliability evaluation of the device, resulting in a large error in the life prediction result. Therefore, this paper proposes a life evaluation method for IGBT modules that takes into account the failure of the bonding wire. The transient thermal impedance of 1200 V/50 A IGBT module under the failure conditions of different numbers of bonding wires is calculated by constructing a finite element simulation model of device electro‐thermal coupling. Both simulation and experimental results show that with the increase of the number of bonding wire failures, the transient thermal impedance curve of the device rises and the steady‐state thermal impedance increases. The Foster thermal network models of the devices are updated, and the number of power cycles of the device with bonding wire failure under DC and sinusoidal pulse width modulation (SPWM) conditions is calculated. When the number of bonding wire failures and fatigue accumulation have a linear relationship, the life will be reduced by 48.29% compared to the healthy state.
High order sliding mode based drift algorithm for a commercial PEM fuel cell system
Authors: Derbeli Mohamed , Saadi Wided , Napole Cristian , Barambones Oscar 
Published: September 2022

AbstractConventional sliding mode controls (SMC) have always shown high robustness when applied to non‐linear systems. However, their applications are still limited due to their high‐frequency switching which could be a harmful phenomenon for different systems. As a solution, this paper proposes a high order SMC based drift algorithm. First, the algorithm is designed theoretically for a proton exchange membrane fuel cell system, where the stability study is proved with Lyapunov theory. Then, it was implemented in a commercial Heliocentris FC50 fuel cell system together with a power converter, a BK Precision 8500 programmable load, and a MicroLabBox dSpace DS1202. Comparative outcomes with the conventional SMC have shown the pros and cons of each scheme in terms of steady‐state oscillations, convergence speed, and robustness.
The scintillating tail of comet C/2020 F3 (Neowise)
Authors: Fallows R. A. , Forte B. , Mevius M. , Brentjens M. A. , Bassa C. G. , Bisi M. M. , Offringa A. , Shaifullah G. , Tiburzi C. , Vedantham H. , Zucca P. 
Published: September 2022

Context. The occultation of a radio source by the plasma tail of a comet can be used to probe structure and dynamics in the tail. Such occultations are rare, and the occurrence of scintillation, due to small-scale density variations in the tail, remains somewhat controversial.
Aims. A detailed observation taken with the Low-Frequency Array (LOFAR) of a serendipitous occultation of the compact radio source 3C196 by the plasma tail of comet C/2020 F3 (Neowise) is presented. 3C196 tracked almost perpendicularly behind the tail, providing a unique profile cut only a short distance downstream from the cometary nucleus itself.
Methods. Interplanetary scintillation (IPS) is observed as the rapid variation of the intensity received of a compact radio source due to density variations in the solar wind. IPS in the signal received from 3C196 was observed for five hours, covering the full transit behind the plasma tail of comet C/2020 F3 (Neowise) on 16 July 2020, and allowing an assessment of the solar wind in which the comet and its tail are embedded.
Results. The results reveal a sudden and strong enhancement in scintillation which is unequivocally attributable to the plasma tail. The strongest scintillation is associated with the tail boundaries, weaker scintillation is seen within the tail, and previously-unreported periodic variations in scintillation are noted, possibly associated with individual filaments of plasma. Furthermore, contributions from the solar wind and comet tail are separated to measure a sharp decrease in the velocity of material within the tail, suggesting a steep velocity shear resulting in strong turbulence along the tail boundary.
Surgical videos on the internet: Is this a reliable pedagogical tool in residency training?
Authors: Ghersi Abdelhamid , Mansour Jad , Marchand Philippe , Al Rubaie Abdallah , Kouyoumdjian Pascal , Coulomb Remy 
Published: September 2022

Introduction: Several open access platforms are currently available to help facilitate this online learning; however, whether the platforms are generalized or specialized, peers do not evaluate videos, and they may teach unverified techniques. The purpose of this study was to compare the quality of each website’s content using a specific measurement, analyzing the pedagogical quality of Femoroacetabular impingement (FAI) arthroscopic videos on YouTube versus VuMedi. Methods: A prospective study analyzing 20 arthroscopy videos of arthroscopic FAI surgery on two hosting platforms online: 10 on the generalist platform YouTube and 10 on a specialized platform VuMedi. Results: The average length of the YouTube videos was 503 ± 355.02 s (198–1430). The average number of views for the YouTube videos was 56,114.6 ± 116,832.61 (1149–383,694). The average length of the VuMedi videos was 797.5 ± 522.5 s (185–1927). The average number of views for the VuMedi video was 10,404.7 ± 10,071.2 (1625–37,115) The average LAP-VEGaS scores of the YouTube and VuMedi videos were 8.2 ± 3.47 (3–15) and 11.95 ± 2.64 (6–15), respectively (p < 0.0005). Discussion: The use of a specialized website makes it possible to obtain educational videos of better quality. Health professionals need to be aware of this when using it as a resource for learning. Therefore, it should be in the interest of educational institutions to participate in the sharing of videos on this platform or to create their own platform to improve the quality of the information provided and the overall pedagogical experience.
Level of evidence: II
Palladium-Catalysed Reductive Aminocarbonylation of Aryl Bromides and Iodides with Nitroarenes
Authors: Moshapo Paseka T. , Mkhonazi Blessing D. , Mabila Euphrent M. 
Published: September 2022

AbstractAmide functional groups are a structural feature in a vast array of beneficial organic molecules. This has resulted in a surge in new methodologies developed to enable access to this functional group using a broad range of coupling partners. Herein, we report a palladium-catalysed reductive aminocarbonylation of aryl bromides and iodides with nitroarenes to afford the respective amide products. The developed protocol employs Mo(CO)6 as a carbonyl source and a combination of Zn and TMSCl as co-reducing agents. For most substrates, the anticipated amide products were obtained in modest to high amide product yields.