bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Clinical Data and Treatment Responses of Patients with Essential Thrombocythemia Using Anagrelide by JAK2 Gene Mutation Status
Authors: GÜLLÜ KOCA Tuba , ÖZKALEMKAŞ Fahir , OZKOCAMAN Vildan , ERSAL Tuba , ESENBUĞA Şeyma 
Published: March 2022

Introduction: Essential Thrombocytemia (ET) is a clonal stem cell disease that manifests itself with proliferation in the megakaryocytic lineage in the bone marrow, with clinical presentations ranging from asymptomatic to bleeding and thrombosis spectrum.
In medical treatment, aspirin and/or monitoring are recommended for low-risk patients, while cytoreductive therapy is recommended for high-risk patients. Cytoreductive therapy is often used in patients with a very high platelet count (>1,000,000). The first choice in cytoreductive treatment is Hydroxyurea, and Anagrelid treatment is preferred in the young patient group and patients with hydroxyurea resistance/intolerance.
This study aimed to evaluate the effects of the JAK2 mutation, which is associated with high risk, in the patient group receiving anagrelide therapy.
Method: The files of patients diagnosed with ET according to 2016 WHO criteria and followed up under Anagrelide therapy in our center between January 2002 and December 2021 were reviewed retrospectively. In addition to the demographic data of the patients, diagnostic tests, bone marrow evaluations, JAK2 mutation status, and laboratory data were noted. Patients were divided into two groups according to JAK2 mutation positivity and negativity. The obtained data were compared between the two groups.
Results: Thirty-three patients (male/female: 20/13) treated with Anagrelide for the diagnosis of ET were included in the study. It was observed that 14 (42%) of the patients were positive for JAK2 mutation. There was no significant difference between the groups regarding age at diagnosis, gender, duration of anagrelide use, and bone marrow fibrosis degrees. When the laboratory tests were compared at the time of diagnosis, the WBC count was significantly higher in the JAK2 positive group; other series were similar. When the last control laboratory data of the patients were compared, WBC, neutrophil, and hemoglobin levels were observed to be significantly higher in JAK2 positive patients, while LDH levels were significantly lower.
Conclusion: It was observed that JAK2 mutation positivity, which is associated with high risk in ET risk staging, did not negatively affect anagrelide treatment response. In ET patients, leukocytosis (>11,000/mm3) has been identified as a risk factor for the whole lifespan. It was observed that the WBC counts of the patients who were positive for JAK2 were significantly higher at the time of diagnosis and during the treatment process. Since the LDH level after treatment is higher in patients with positive JAK2 mutation, it has been evaluated that JAK2 mutation may play a role in resistance to cytoreductive therapy.
La tecnología en la formación docente
Authors: Chiquini Charlotte Monserrat Llanes , Canul Carlos Alberto Pérez , Cortés Roger Manuel Patrón , Chuc Giselle Guillermo , Álvarez Diana Concepción Mex 
Published: March 2022

Este proyecto surge de la necesidad de proponer acciones que promuevan el uso y apropiación de las TIC entre las personas que fungen como docentes en las instituciones de educación superior de nuestro país. Para ello fue necesario obtener evidencias acerca del conocimiento que los profesores universitarios tienen de estas tecnologías y el modo en que hace uso de ellas, si es que las usan, pues existen algunos indicios que apuntan en el sentido de que no todos los profesores aprovechan las posibilidades que las TIC brindan como herramienta en la formación profesional de los alumnos. Sin duda, un mejor conocimiento y uso de las TIC por parte de los profesores potencia las posibilidades de mejorar la calidad de la enseñanza, elemento sine qua non podremos ingresar como país en la sociedad del conocimiento; no cabe duda de que México deberá enfocar sus esfuerzos en esa dirección.
Diet high in α-linolenic acid up-regulates fatty acids biosynthesis-relate gene expression in the hepatopancreas of Yellow River carp (Cyprinus carpio)
Authors: Ren Hong-tao , Zhang Xiao nan , Wang Qi zheng , Duan Sheng hui 
Published: March 2022

Little information on the effects of a high α-linolenic acid (C18:3n-3) diet on fatty acid composition and lipid-producing gene expression in the hepatopancreas from Yellow River carp (Cyprinus carpio). In the study, 60 common carp juveniles were fed for 50 days, a high α-linolenic acid diet supplemented with linseed oil (LO), and a control diet without the addition of linseed oil to evaluate the effect on lipid composition and gene expression of peroxisome proliferator-activated receptors (PPAR-α), delta-6 fatty acid desaturase (delta-6-Fad), stearoyl-CoA-desaturase (SCD), and fatty acid desaturase-5 (Elovl5) in the hepatopancreas. The results showed that increased levels of C20:4n-6, C18:3n-3, C20:5n-3, and C22:5n-3 were observed in LO treated Yellow River carp hepatopancreas. PPAR-α, delta-6-Fad and Elovl5 gene expression was up-regulated in the Yellow River carp’s hepatopancreas fed with a high α-linolenic acid diet (P < 0.05), while SCD gene was down-regulated. In conclusion, the addition of α-linolenic acid to the Yellow River carp diet affected gene expression (SCD, PPAR, delta-6-Fad, and Elov15) involved in regulating fatty acid (FA) profile Yellow River carp. It is suggested that delta-6-Fad, Elovl5, and PPAR-α be essential messengers responsible for translating nutritional stimuli into gene expression changes in the hepatopancreas.
THE MEDICOLEGAL VIEW OF THE RAINS AND LANDSLIDES IN THE SERRANA REGION OF RIO DE JANEIRO: A LITERATURE REVIEW
Authors: Moura Julia , Paiva Laura , Jardim Letícia , Magalhaes Lohana , Reis Luiza , Silva Mayume 
Published: March 2022

Introduction: The article is a literature review that aims to analyze, from the perspective of Legal Medicine, the consequences of rains and landslides in the Serrana region of Rio de Janeiro in 2011, with an emphasis on the work of medical examiners with regard to medical expertise in large-scale disasters. Method: The bibliographic databases used to search the National Library of Medicine (PUBMED) and Scientific Electronic Library Online (SCIELO), in addition to manuals, magazines, and a literature listed in the Fundamentals of Legal Medicine by Genival Veloso de França. All the selected bibliography was published between the years 2008 to 2022. Conclusão: After the discussion and analysis of the data, it was possible to conclude that in calamitous events, sudden and of harmful proportions, it is essential that the process of identification of the human bodies be carried out by a qualified team of medical experts, followed by scientific forensic identification criterion, thus avoiding inaccuracies in this process.
Effect of risk factors on the outcomes of COVID-19-infected intensive care patients: a single-center retrospective study
Authors: Sapra Aditya , VU Jagadeeswaran , Jha Shyamal , HN Madhusudana , Muzammil Mohammad , Majumdar Meghna , Arya Jeet Singh , Sheoran Aarti 
Published: March 2022

Background: To date, little attention has been paid to the impact of risk factors on the outcome of patients with coronavirus disease 2019 (COVID-19) hospitalized in the intensive care unit (ICU). This study was performed to examine the effects of risk factors on death among COVID-19 patients hospitalized in the ICU.
Methods: From April 2020 to November 2020, data on 141 COVID-19-infected intensive care patients at 7 Air Force Hospital, Kanpur, were retrospectively retrieved. All analyses were performed using SPSS statistical software (SPSS Inc., Chicago, IL, USA, 15.0). Bivariate and multivariate logistic regression analysis was done to identify independent risk factors. A p-value <0.05 was considered statistically significant.
Results: Most of study population were males (69.5%) with mean age of 59.8 ± 17.5 years. Out of 141 patients, 60 (42.6%) patients had comorbidities and 81 (57.4%) patients had no comorbidities. ICU death rates were 46.1%. Bivariate logistic regression analysis revealed that male sex (OR:0.45;95%CI:0.21-0.94), diabetes mellitus (OR:2.96; 95%CI:1.16-7.54), coronary artery disease (OR:2.48;95%CI:0.83-7.37), chronic kidney disease (OR:0.13,95% CI:0.02-1.12), patients with one (OR:1.25,95%CI:0.54-2.86) or more than two comorbidities (OR:1.95,95%CI:0.81-4.70), and who required high flow oxygen therapy (OR:13.30,95%CI:5.81-30.43), non-invasive (OR: 0.10,95% CI:0.02-0.45) and invasive ventilators (OR:0.04,95%CI:0.02-0.09) all were associated with higher ICU death rates. Multivariable logistic regression found following independent risk factors for death: patients with one comorbidity (OR:0.10;95%CI:0.02-0.66), non-invasive ventilator (OR:0.005;95%CI:0.000-0.091), and invasive ventilator (OR:0.003;95%CI:0.000-0.032).
Conclusion: Identification of risk factors is of utmost importance to reduce death in COVID-19 infected intensive care patients.
DIASPORAS AS DEVELOPMENT PARTNERS FOR HOME COUNTRIES: A CASE FOR TANZANIA
Authors: Londo Dennis Lazaro 
Published: March 2022

Diasporas have often been an integral part of community development in both host and home countries. Despite their efforts to send money back to their home countries there are very few governments existing today that have incorporated the Diaspora as development partners. This study reviews specifically the existing policies by the Diaspora home governments to incorporate them as development partners with the Tanzanian government being a case study. The study also gives suggestions on how Diaspora home governments could enhance policies to accommodate the non-financial contributions of the Diaspora towards their home governments. This study reviewed literature and analyzed findings from interviews conducted on Tanzanian Diaspora living in the capital of Finland, Helsinki. The study found out mainly that most governments are concerned with the Diaspora remittances which overlook the non-financial contributions from the Diaspora that can contribute to community development. With regard to such existential knowledge gaps, this study provides with knowledge on how to improve Diaspora engagement in home countries.
ANALYSIS OF THE MAIN SOURCES OF INCOME FOR HOUSEHOLDS IN MBITA DIVISION OF MBITA SUB COUNTY: KENYA
Authors: Ogweno Jacob Ogweno , Ndhune Joseph Ochieng 
Published: March 2022

Purpose: Sources of income for daily survival has been an issue of a great concern to several households in developing economies in the world over, Kenya included. Households have continued to struggle and diversify means of living and make daily ends meet. Some economists attribute this phenomenon to high level of unemployment, low level of education, poor technology to meet the international labor market demands and poor governance interns of local job creation. The medium-term plan report covering the period 2008-2012 indicated that Mbita Division of Homa Bay County had numerous challenges for the households in their efforts to meet daily needs and experienced weak purchasing power despite the efforts and strategies initiated by both national and county governments to boost the household incomes. The purpose of this study was therefore to identify and document the main sources of income of households in Mbita DivisionMethodology: The study adopted exploratory and correlation research designs. Exploratory research design gave an insight into the households’ expenditure behavior while correlation research design facilitated the establishment of relationships among the research variables. A sample size of 374 heads of households was selected from a total of 13,789 households in the Division. The individual respondents were drawn by the use of a simple random sampling technique. Primary data was gathered with the help of questionnaires, key informant interviews, focused group discussions, and observation, and Secondary data was collected from Government statistical abstracts, household records, and relevant textbooks. Regression as a tool of analysis was utilized to reveal the existing relationship among the variables and coefficient of determination to show the strength of the established model. The reliability of the data collection instrument was tested using the internal consistency technique in which the scores obtained from the subjects were correlated and the Cronbach’s Coefficient Alpha was be computed to determine the correlation among the items.Findings: The researcher established that fishing, peasant farming, charcoal burning and micro-business activities formed the backbone of the sources of income for the households in Mbita Division.
DONOR POWER AND PRIORITIZATION IN DEVELOPMENT ASSISTANCE FOR HEALTH POLICIES: THE CASE OF UGANDA
Authors: Nagemi Charity , Mwesigwa Catherine 
Published: March 2022

Purpose: The study sought to fill the knowledge gap by examining whether there were changes in Health Financing policies for Uganda’s health care system from 2002 to 2015 and their impact.
Methodology: Literature on aid for health in low and middle-income countries was reviewed, while data on major donors to Uganda’s health care system obtained from their websites, as well as the Creditor Reporting System. Walt and Gilson’s health policy triangle framework was used to examine how different donors operated in Uganda’s health financing space. Vertical, horizontal, earmarked and budget support, as well as disease-specific fund allocation modes were also explored.
Findings: Overall, donors influenced decisions on the selection of priority areas as well as fund allocation, despite efforts to involve the government in health policy formulation. The results were intended as an overarching guide for both donors and health policy-makers in future health financing decision making processes.
Unique contribution to theory, practice and policy: Country engagement and policy ownership are critical to ensure harmonization of donor interests and country health needs. Increased aid for Health Systems Strengthening, Primary Health Care and Non-Communicable Diseases would also go a long way in improving population outcomes. Further studies on the sustainability of Development Assistance for health for middle and low-income countries are recommended.
From Sustainable Development to Sustainable Retreat, Brundtland to Lovelock: what has Africa in it?
Authors: Kikoh Ezekiel , Ngala Kiming 
Published: March 2022

Purpose: The purpose of this paper was to show that James Lovelock proposed “Sustainable Retreat” opposed to the UN Predatory Sustainable Development doesn’t fit the African ecology and development, African ecology as well as others of less developed and developing countries are preys to coalition UN-Sustainable Development. It tries to answer the question: What has African ecology in sustainable development/retreat?
Methodology: Using the archaeologico-critical method, this paper traces, evaluates the history of sustainable development/retreat and show cases the possibility of an African “special development/technology status” in a new sustainable development which is ecology-centered.
Findings: Findings show that first, concerning Lovelock’s Sustainable Retreat, Africa is still at embryonic phase of its development/technology so it cannot be put into the industrialized nations’ policy of sustainable development/retreat. Secondly, the UNO-born Sustainable Development/Technology which emerged with the UN Brundtland’s commanded Report of 1987 is a bluff at the service of hyper neoliberal forces (market forces). Furthermore, to show that “Business as usual” follows its normal trend under the auspices of an accomplice UN-Sustainable Development accords and goals while the ecological macro equilibrium of the planet deteriorates. This masked coalition Sustainable Development-neoliberal forces has pushed industrialization technology too far to the point where if it is not halted and retreated the planet’s ecological equilibrium will crash.
Unique Contribution to Theory, Practice and Policy: The unique contribution of this paper to theory is transcending sustainable development/retreat and forging a new development set up that fits the African ecology. The recommendations are such that the UN-Sustainable Development pyramid domination of economy over social and environment is inversed and that the social, environment dominate the economy and finally that the special status is void of the idea of Africa as “depot of raw material”, nations’ dependency on ecological resources as principal source of income and the formation of local, national and regional African “tug of war” with predatory international neoliberal forces.
ROAD NETWORK AND HOUSEHOLD FOOD SECURITY IN ACHOLI SUB REGION, NORTHERN UGANDA: A PRAGMATIC PERSPECTIVE
Authors: Namubiru Margaret  , Nsambu Fredrick Kijjambu , Ngaka Willy , Rwakihembo John 
Published: March 2022

Purpose: This study aimed at examining the relationship between road network and household food security in Acholi subregion, northern Uganda.
Methodology: The study adopted a pragmatic paradigm, thus adopting a mixed methods approach. Quantitative data was collected from 384 respondents using a structured questionnaire while face-to-face interviews aided qualitative data collection. After data management and processing, Pearson correlation and standard regression were use for data analysis.
Findings: It was observed that road network is positively and significantly associated with household food security. The study established that road network accounts for 10% of the variance in food security among households in Acholi subregion, northern Uganda.
Unique contribution to practice and policy: Although there are conflicting views on the predictors of food security among households, the present study has confirmed thatroad network plays a critical role in influencing food security among households in Acholi subregion, Northern Uganda, thus serving its purpose.
Pentingnya Publikasi Ilmiah Bagi Guru
Authors: Hasan Hasan , Rahmani Dienny Redha 
Published: March 2022

Nowadays a person's competence can be seen from how many writings he makes according to his competency. Likewise with the teaching profession, namely teachers. The teacher not only teaches students in class but is also required to be able to write their ideas through writing published in books and scientific journals both national and international accredited.
One of the various activities in the framework of developing the teaching profession can be seen from how many of the number of teacher publications published in the form of books and mass media, moreover scientific journals, but in reality scientific publications from teachers are still considered minimal. Whereas, basically writing this kind of scientific writing is believed to be able to improve the professionalism of the teacher while improving the quality of the learning it conveys.
More than that also scientific publications for teachers as a prerequisite for promotion and position so as to provide more motivation for them to make higher quality scientific work. This research method uses library research or library research. The conclusion in this study is that scientific publications for teachers besides being considered important because of the following, namely one of the conditions for promotion and position of the teacher, the existence of the competency of the teacher concerned and also developing and disseminating knowledge.
INTENSIFIKASI PEMUNGUTAN DAN EKSTENSIFIKASI SUMBER PAD TERHADAP KEMANDIRIAN KEUANGAN DAERAH PEMEKARAN: STUDI PADA KABUPATEN SERAM BAGIAN BARAT DAN KABUPATEN KEPULAUAN ARU PROVINSI MALUKU
Authors: Wenno Meiske 
Published: March 2022

This research discussing the finance self-support problem by using intensification of collection and extensification of PAD source at the government of West Seram District and Aru Island District, Maluku Province. The objective of research is to test and analyzing the factors establishing the intensification of collection and extensification of PAD source, to test and analyzing the effect of intensification of collection and extensification of PAD source on local finance self-support, and recommending a strategy to the government of West Seram District and Aru Island District in pursuance of the local finance self-support. Population this research is civil servants on the government office at West Seram District and Aru Island District who runs the function as assigned to manage and to produce PAD amounts 744 civil servants in the scope of the government office at West Seram District and Aru Island District. This research use factor analysis and multiple regression analysis. Result of research indicates that the implementation of intensification of collection and extensification of PAD source in the government at West Seram District and Aru Island District have significantly influenced the improvement of local finance self-support.
ANALISIS DETERMINAN TRANSFER PEMERINTAH PUSAT BERUPA DANA ALOKASI KHUSUS PADA KABUPATEN/KOTA DI PROVINSI MALUKU
Authors: Laitupa Abdul Azis 
Published: March 2022

Implementation of regional autonomy in Indonesia provides the right and authority for the government to explore its potential and improve its financial performance to meet the needs and services. This study was to observe the effect of the independent variable is economic growth that is proxied by the PDRB, the original income (PAD) and the number of population on the dependent variable is the Special Allocation Fund (DAK) in Ambon City, Central Maluku and Southeast Maluku regency in Maluku province from the year 2003-2013. the method used in this research is panel data regression. The results showed that there is significant influence of the independent variable, economic growth is proxied by the PDRB, revenue (PAD) and the number of population on the amount of central government assistance in the form of general allocation funds in Ambon City, Central Maluku and Southeast Maluku District in the Province Maluku.
CHẤT LƯỢNG CUỘC SỐNG LIÊN QUAN ĐẾN SỨC KHỎE BỆNH NHÂN TRƯỚC VÀ SAU NỘI SOI PHẾ QUẢN GÂY MÊ
Authors: Dũng Vũ , Quý Châu Ngô 
Published: March 2022

Mục đích: Nhận xét chất lượng cuộc sống liên quan đến sức khỏe của bệnh nhân trước và sau khi nội soi phế quản. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang trên 60 bệnh nhân được soi phế quản tại Trung tâm Hô Hấp- Bệnh viện Bạch Mai từ 7/2020 đến 7/2021. Kết quả: Ngay sau khi soi phế quản, chất lượng cuộc sống của bệnh nhân giảm rõ rệt, đa số bệnh nhân phải nằm nghỉ tại giường. Sau soi 0h, chất lượng cuộc sống bệnh nhân ở bậc 1 vẫn nhiều nhất chiếm 40%, tiếp theo là bậc 0 chiếm 31.7%, bậc 2 chiếm 23.3%, bậc 3 chiếm 3.3%. Chất lượng cuộc sống bệnh nhân ở 24h sau soi bậc 1 chiếm nhiều nhất chiếm 55%, tiếp theo là bậc 2 chiếm 21.7%, bậc 0 chiếm 18.3%. Kết luận: Chất lượng cuộc sống của bệnh nhân giảm đi sau khi soi phế quản nhưng trở về gần như lúc trước khi soi phế quản sau 24 giờ.