bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Acetylsalicylic Acid (Asa) on the Mechanical Properties of
Breast Cancer Epithelial Cells
Authors: Milani Dornaz , Khorramymehr Siamak , Vasaghi-Gharamaleki Behnoush 
Published: January 2022

Background:
In most communities, the risk of developing breast cancer is increasing.
By affecting the cyclooxygenase 1 and 2 (COX-1 and COX-2) enzymes and actin filaments, acetylsalicylic
acid (Aspirin) has been shown to reduce the risk of breast cancer and prevent cell migration
in both laboratory and clinical studies.

Methods:
The purpose of this study is to determine the mechanical properties of normal and cancerous
breast tissue cells, as well as the short-term effect of aspirin on cancer cells. To this end, the
mechanical properties and deformation of three cell types were investigated: healthy MCF-10
breast cells, MCF-7 breast cancer cells, and MCF-7 breast cancer cells treated with a 5 μM aspirin
solution. Atomic Force Microscopy (AFM) was used to determine the mechanical properties of the
cells. Cell deformation was analyzed in all groups, and Young's modulus was calculated using the
Hertz model.

Result:
According to the obtained data, cancer cells deformed at a rate half that of healthy cells.
Nonetheless, when aspirin was used, cancer cells deformed similarly to healthy cells. Additionally,
healthy cells' Young's modulus was calculated to be approximately three times that of cancer cells,
which was placed closer to that of healthy cells by adding aspirin to Young's modulus.

Conclusion:
Cell strength appears to have increased due to aspirin's intervention on actin filaments
and cytoskeletons, and the mechanical properties of breast cancer cells have become more similar
to those of normal cells. The likelihood of cell migration and metastasis decreases as cell strength
increases.
Metainflammation in COVID-19
Authors: Bakhtiari Mojtaba , Asadipooya Kamyar 
Published: January 2022

Abstract:
A new coronavirus pandemic, caused by severe acute respiratory syndrome corona-virus 2 (SARS-CoV-2), has been on the rise. This virus is fatal for broad groups of populations, including elderly, men, and patients with comorbidities among which obesity is a possible risk factor. The pathophysiologic connections between obesity/metainflammation and COVID-19 may be directly related to increasing soluble ACE2 (angiotensin-converting enzyme 2) levels which potentiate the viral entrance into the host cells, or indirectly related to dysregulation of immune system, microvascular injury and hypercoagulability. The SARS-CoV-2 S-glycoprotein interacts mainly with ACE2 or possibly DPP4 receptors to enter into the host cells. The host proteases, especially TMPRSS2 (transmembrane protease serine 2), support the fusion process and virus entry. While membranous ACE2 is considered a port of entry to the cell for SARS-CoV-2, it seems that soluble ACE2 retains its virus binding capability and enhances its entry into the cells. Interestingly, ACE2 on cell membrane may have protective roles by diminishing cyto-kine storm-related injuries to the organs. Applying medications that can reduce soluble ACE2 levels, antagonizing TMPRSS2 or blocking DPP4 can improve the outcomes of COVID-19. Met-formin and statins through immunomodulatory activities, Orlistat by reducing viral replication, and thiazolidinediones by upregulating ACE2 expression have potential beneficial effects against COVID-19. However, the combination of dipeptidyl peptidase-4 (DPP4) inhibitors and spirono-lactone/eplerenone seems to be more effective by reducing soluble ACE2 level, antagonizing TMPRSS2, maintaining ACE2 on cell membrane and reducing risk of viral entry into the cells.
Molecular Study of Escherichia albertii in Pediatric Urinary Tract Infections
Authors: Zaki Maysaa El Sayed , Eid Abd ElRahman , El-Kazzaz Samah Sabry , El-Sabbagh Amr Mohamed 
Published: January 2022

Background:There are insufficient data about the presence ofE. albertiias a causative organism in urinary tract infection in pediatric patients. Objective: The present study aimed to detectE. albertiiby polymerase chain reaction (PCR) for detection ofuidA, mdh,andlysPgenes among isolatedE.colifrom children with urinary tract infection.Methods:The present study was a cross-sectional retrograde study which was carried out on 100 isolates of phenotypically confirmedE.colidetected in urine samples of children suffering from urinary tract infection. The isolates were subjected to molecular identification by PCR foruidA, mdh,andlysPgenes.Results:E. albertiiwas identified by PCR in 7% of the isolates andE.coliwas identified in 93% of the isolates. TwomdhandlysPgenes were detected forE. albertiiand theuidAgene forE. coli.E. albertiiisolates had marked resistance to gentamicin (71.4%), followed by resistance to ciprofloxacin (57.1%), meropenem and imipenem (42.9% each) and ESBL activity by double discs method was reported in 57.1% of the isolates. However, none of the isolates had shown resistance to nalidixic acid and only one isolate had resistance to norfloxacin. There was a statistically insignificant difference between resistance to the used antibiotics such as aztreonam (P=0.083), ampicillin/clavulanate (P=0.5), ciprofloxacin (P=0.69), gentamicin (P=0.3) and ceftazidime (P=1.00).Conclusion:The present study highlights the emergence ofE. albertiias a pathogen associated with urinary tract infections in children. There is marked antibiotic resistance of this pathogen, especially toward extended spectrum beta-lactams antibiotics. The identification method depends mainly on genetic studies. Further longitudinal studies with large number of patients are required to verify the accurate prevalence of this bacterium.
An Epidemiological Study of Kidney Calculi in Western Guangdong
Authors: Li Jialong , Li Kun , Gao Chang , Huang Zunnan 
Published: January 2022

Objective:
To investigate the risk factors of kidney calculi in its high prevalence areas of
western Guangdong, and provide the proper prevention measures.

Methods:
A cross-sectional survey was conducted among individuals in Maoming, western Guangdong.
Univariate and Poisson regression analyses were applied to investigate the influence of the
epidemiology, lifestyle, and environmental factors on renal calculi. Risk ratios with 95% confidence
interval were used to estimate the association between the investigated factors and the prevalence of
renal calculi.

Results:
500 questionnaires were sent out and 481 valid questionnaires were recycled. Among 481
respondents, 84 had renal calculi with a prevalence rate of 17.46%. Univariate regression analysis
showed statistically significant differences in the prevalence of renal calculi among different groups
of sex, ages, family history of kidney calculi, diet and drinking habit. Poisson regression analysis
showed that daily water intake and drinking boiled water were protective factors, while male, family
history of kidney calculi, diet high in protein, sugar, vitamin C and calcium were risk factors. Additionally,
high sugar diet was not statistically significantly associated with the occurrence of renal
calculi.

Conclusion:
The occurrence of kidney calculi in western Guangdong is closely related to demographic
characteristics of individuals, living and dietary habits of the resident populations.
Disulfiram: A Repurposed Drug in Preclinical and Clinical Development
for the Treatment of Infectious Diseases
Authors: Custodio Marco M. , Sparks Jennifer , Long Timothy E. 
Published: January 2022

Abstract:
This article reviews preclinical and clinical studies on the repurposed use of disulfiram (Antabuse) as an antimicrobial agent. Preclinical research covered on the alcohol sobriety aid includes uses as an anti-MRSA agent, a carbapenamase inhibitor, antifungal drug for candidiasis, and treatment for parasitic diseases due to protozoa (e.g., giardiasis, leishmaniasis, malaria) and helminthes (e.g., schistosomiasis, trichuriasis). Past, current, and pending clinical studies on di-sulfiram as a post-Lyme disease syndrome (PTLDS) therapy, an HIV latency reversal agent, and intervention for COVID-19 infections are also reviewed.
Cruciferous Vegetable Intervention to Reduce the Risk of Cancer Recurrence in Non–Muscle-Invasive Bladder Cancer Survivors: Development Using a Systematic Process
Authors: Yeary Karen H Kim , Clark Nikia , Saad-Harfouche Frances , Erwin Deborah , Kuliszewski Margaret Gates , Li Qiang , McCann Susan E , Yu Han , Lincourt Catherine , Zoellner Jamie , Tang Li 
Published: January 2022

Background
Bladder cancer is one of the top 10 most common cancers in the United States. Most bladder cancers (70%-80%) are diagnosed at early stages as non–muscle-invasive bladder cancer (NMIBC), which can be removed surgically. However, 50% to 80% of NMIBC cases recur within 5 years, and 15% to 30% progress with poor survival. Current treatments are limited and expensive. A wealth of preclinical and epidemiological evidence suggests that dietary isothiocyanates in cruciferous vegetables (Cruciferae) could be a novel, noninvasive, and cost-effective strategy to control NMIBC recurrence and progression.

Objective
The aim of this study is to develop a scalable dietary intervention that increases isothiocyanate exposure through Cruciferae intake in NMIBC survivors.

Methods
We worked with a community advisory board (N=8) to identify relevant factors, evidence-based behavior change techniques, and behavioral theory constructs used to increase Cruciferae intake in NMIBC survivors; use the PEN-3 Model focused on incorporating cultural factors salient to the group’s shared experiences to review the intervention components (eg, the saliency of behavioral messages); administer the revised intervention to community partners for their feedback; and refine the intervention.

Results
We developed a multicomponent intervention for NMIBC survivors consisting of a magazine, tracking book, live telephone call script, and interactive voice messages. Entitled POW-R Health: Power to Redefine Your Health, the intervention incorporated findings from our adaptation process to ensure saliency to NMIBC survivors.

Conclusions
This is the first evidence-based, theoretically grounded dietary intervention developed to reduce bladder cancer recurrence in NMIBC survivors using a systematic process for community adaptation. This study provides a model for others who aim to develop behavioral, community-relevant interventions for cancer prevention and control with the overall goal of wide-scale implementation and dissemination.
Kematangan emosi dan penyesuaian perkawinan pada pernikahan usia muda di Kabupaten Tulungagung
Authors: Mayangsari Puput Dwi , Prabowo Adhyatman , Hijrianti Udi Rosida 
Published: January 2022

The phenomenon of marriage at a young age is increasing in Tulungagung. Teenagers who decide to marry young will experience some negative impacts, especially if they are not accompanied with a mature emotional state. The purpose of this study was to determine the relationship between emotional maturity and marital adjustment in young marriages. This study uses quantitative methods. Subjects are selected using purposive sampling technique with the criteria of couples who married when their age is less than 21 years old, with a marriage age of 1-5 years in Tulungagung Regency. This study obtained as many as 83 respondents. This study collected data using a scale of emotional maturity and marriage adjustment through google form and then analyzed using the correlation product moment formula. The results showed the value of r = 0.534 (p <0.05) which means that there is a positive relationship between emotional maturity and marital adjustment. The higher the emotional maturity, the higher the marital adjustment. Vice versa, if emotional maturity is low, marital adjustment will also be low.

Keywords: Early age marriages, emotional maturity, marital adjustment
Sociological Analysis of the Important Characters in Kevin Kwan’s Crazy Rich Asians
Authors: Gusti Ayu Made Rai Suarniti  
Published: January 2022

This research is about the sociological problems of five important characters in Kevin Kwan’s Crazy Rich Asian. Rachel Chu is the main character in this story comes from the middle class society. She has a relationships with Nicholas Young who comes from the upper class society. They face a lot of problems especially from Nicholas’s family who doesn’t agree with their relationships. Different society influences the character of someone. That’s why this research is aimed to find out the types of social class and the influence of social class on the character that showed in the story. The data were collected by reading the novel thoroughly then using the note-taking technique before being identified based on the topic. The collected data were descriptively analyzed by using qualitative-descriptive method to classify the types of social class and the influence of social class on the character that found in this novel. Based on the result of the research, it is found that there are three kinds of social class in Kevin Kwan’s Crazy Rich Asian, those are: Upper class, Middle class and Working class. Rachel Chu who comes from the middle class society has a simple personality. She prefers to save her money for food though she is a lecturer in university rather than her boy friend, Nicholas Young who comes from the worthy family. Nick’s family are also live glamor in Singapore. They spend a lot of money for fashion and jewelry. It much different with Rachel’s mom ( Kerry Chu) who originally comes from working or lower class society. She fulfills her daughter alone and becomes a single parent because she has divorced with her husband when Rachel still child. This condition make Eleanor Young doesn’t agree with the relationships however the power of love between Nick and Rachel defeated everything. Finally, they become a couple.
PKM Teknologi Fermentasi Pakan Jerami Padi dan Pembuatan Pupuk Organik Pada Kelompok Ternak “Sato Luwih” Desa Kenderan Kecamatan Tegalalang-Kabupaten Gianyar
Authors: Sudita I Dewa Nyoman , Situmeang Yohanes Parlindungan , Amerta Kadek Suniasta 
Published: January 2022

Pemerintah daerah provinsi Bali secara terus menerus mendorong masyarakat petani ternak untuk membentuk kelompok-kelompok ternak khususnya ternak sapi induk, melalui program Simantri sejak tahun 2009/2010 dan sekarang disebut dengan Sipadu. Selain program tersebut juga terbentuk kelompok ternak secara mandiri oleh petani ternak yang tersebar di Bali, salah satunya adalah kelompok ternak “Sato Luwih”di Desa Kendran, Tegalalang-Gianyar, yang memerlukan pembinaan dan pendampingan dalam pemberdayaan sumber daya yang dimiliki yaitu ternak dan limbah yang dihasilkan. Kelompok ternak yang ada di desa Kendran ini baru terbentuk pada awal tahun 2020, dimana para anggotanya memiliki kemampuan yang berbeda dalam beternak baik yang sudah berpengalaman maupun yang baru mulai belajar beternak. Disamping itu sumber daya yang ada berupa limbah ternak sapi belum dimanfaatkan, disatu sisi limbah terbut masih memiliki potensi untuk menambah pendapatan kelompok apabila diolah menjadi pupuk organik kompos. Masalah yang dihadapi oleh kelompok dan anggota kelompok adalah masih kurangnya pengetahuan dalam manajemen pemberian pakan ternak memanfaatkan jerami padi, pengetahuan tentang teknologi pengolahan limbah kotoran sapi baik faeces maupun urine menjadi pupuk organik, dan kurangnya pemahaman tehadap penggunaan pupuk organik kompos dalam sistim usaha taninya. Oleh karena itu melalui kegiatan PKM perlu diberikan pendampingan dan transfer teknologi terapan pada para anggota kelompok, sehingga pendayagunaan sumber daya yang dimilki dapat dimanfaatkan secara optimal. Metode yang digunakan dalam kegiatan PKM ini yaitu : observasi dan diskusi kelompok, penyuluhan, dan praktek lapang. Diskusi kelompok dilakukan dengan melibatkan para pengurus kelompok untuk menentukan pemberian materi kegiatan dan jadwal pelaksanaan. Penyuluhan dilakukan kepada semua anggota kelompok tentang pembuatan fermentasi pakan jerami dan pembuatan pupuk organik kotoran ternak sapi. Sedangkan praktek dilakukan secara langsung dikerjakan oleh anggota kelompok, dan telah dilakukan evaluasi hasilnya. Hasil PKM didapatkan para anggota kelompok telah mampu melakukan pembuatan fermentasi jerami sebagai pakan ternak dan memanfaatkan limbah kotoran ternak menjadi pupuk organik, sehingga dapat menjaga kebersihan lingkungan kandang. Dari kegiatan PKM ini dapat disimpulkan sudah terjadi perubahan prilaku pada anggota kelompok yaitu pengetahuan dan ketrampilan, sedangkan perubahan sikap masih perlu diadakan observasi lapangan.
PENGARUH COKELAT HITAM TERHADAP INTENSITAS NYERI DISMENORE PRIMER PADA MAHASISWI AKADEMI KEBIDANAN SALEHA BANDA ACEH
Authors: Febriansyah Evan , Nuha Kaifar , Kamal Shela 
Published: January 2022

Perempuan merupakan makhluk yang memiliki sistem reproduksi yang cukup unik yaitu mengalami haid setiap bulannya. Perempuan yang mengalami menstruasi, biasanya mengalami nyeri dengan tingkat dan sifat yang berbeda-beda mulai dari nyeri ringan hingga nyeri berat. Kondisi tersebut dinamakan Dismenorhea, yaitu suatu keadaan simptomatik yang meliputi nyeri abdomen, kram dan sakit pada bagian punggung saat menstruasi yang dapat mengganggu kegiatan sehari-hari. Angka kejadian dismenorea tipe primer di Indonesia sekitar 54,89% pada wanita usia subur. Mengkonsumsi dark chocolate diketahui dapat meningkatkan jumlah magnesium dalam tubuh dan mengurangi rasa sakit saat menstruasi. Penelitian ini bertujuan untuk mengetahui pengaruh cokelat hitam terhadap penurunan nyeri dismenorhae primer. Penelitian ini merupakan penelitian kuantitatif dengan jenis penelitian quasi eksperimen. Desain yang digunakan pada penelitian ini adalah one group pretest–posttest desain. Adapun sampel pada penelitian ini adalah mahasiswi akademi Kebidanan Saleha Banda Aceh yang mengalami dismenorhea ditetapkan sebanyak 30 orang sebagai kelompok perlakuan dengan teknik pengambilan sampel non-probability sampling, yaitu quota sampling.KelompokPeneliti akan mendatngi sampel saat sampel mengalami dismenorhea, lalu meminta sampel mengisi ukuran skala nyeri sesuai yang dirasakan, lalu sampel akan cokelat hitam batang 72% sebanyak 35 gram untuk dikonsumsi dan tingkat nyeri akan diukur lagi 2 jam setelah cokelat dihabiskan. Berdasarkan hasil perhitungan uji Wilcoxon menunjukkan bahwa nilai signifikansi (Sig.) sebesar 0,000 kurang dari α (α=0,05). Hal ini menunjukkan terdapat perbedaan bermakna antara skala nyeri dismenorhea sebelum dan sesudah diberikan cokelat hitam. Mengkonsumsi cokelat hitam 72% sebanyak 35 gram berpengaruh terhadap penurunan intensitas nyeri haid dismenorhae primer pada remaja.
DENSITAS MIKROFILARIA PADA RESERVOIR DI WILAYAH ENDEMIS FILARIASIS KABUPATEN ACEH JAYA
Authors: Yulidar Yulidar , Rosdiana Rosdiana , Manik Ulil Amri , Wilya Veny , Ramadhan Nur , Randiana Eka , Muhsi Ibnu 
Published: January 2022

Kabupaten Aceh Jaya termasuk wilayah endmeis filariasis. Pelaksanaan Program pemberian obat pencegahan massal (POPM) lima putaran dilakukan dari tahun 2011 sampai 2015. Oleh karena gagal pre-TAS pada tahun 2016, maka dilakuakn POPM 2 putaran lagi tahun 2017 dan 2018. Evaluasi pelaksanaan program pengendalian filariasis berjalan dengan baik namun aspek penyebab kegagalan POPM tidak diketahui secara pasti. Banyak hal yang menjadi faktor resiko penularan filariasis diantaranya keberadaan agent, host (manusia dan hewan) dan faktor lingkungan. Penelitian ini dilakukan bertujuan untuk mendapatkan gambaran densitas mikrofilaria pada reservoir di wilayah endemis filariasis Kabupaten Aceh Jaya terutama Desa Lhok Bout dan Desa Ligan. Penelitian ini merupakan cross sectional dan jumlah hewan yang tertangkap bersifat purposive sampling pada 100 hewan yaitu kucing dan monyet ekor panjang. Pengumpulan data dilkaukan pada bulan Agustus dan Oktober 2017 di Desa Ligan dan Desa Lhok Bout Kabupaten Aceh Jaya. Hasil pemeriksaan mikroskopis pada 83 kucing dan 17 monyet ekorv panjang adalah 4 slide darah kucing ditemukan positif Brugia malayi dan 2 slide darah monyet ekor panjang ditemukan cacing non Brugia malayi yang dicurigai adalah Dilofillaria sp. Oleh karena, kucing dan amonyet ekor panajng positif terdapat cacing mikrofillaria di dalam darahnya maka Kabuapetn Aceh Jaya termasuk wilayah endemis zoonotik reservoir filariasis. Untuk wilayah yang zoonotic reservoir filariasis, pengendalian filariasis tidak hanya pada agent, host manusia namun juga harus memperhatikan host reservoir.Pengendalian cacing Brugia malayi atau non Brugia malayi pada reservoir juga harus dilakukan untuk pemutusan rantai penularan selain pengendalian vector dan usaha lainnya.
What Makes an Ethnographer? Institutionalized Teaching and Informal Learning of Anthropology in Romania
Authors: Iorga Alexandru 
Published: January 2022

The processes of disciplinary institutionalization emerged from practices of preserving written and oral documents, establishing local and national museums, and developing university courses. In the last 100 years, archives’ development assured the professionalization of scholars interested in disciplines unrepresented at the university level, such as ethnography and anthropology. After the 1990s, as the South-Eastern European countries could not imagine an alternative path of development, a westernization process emerged as the main strategy for catching-up with Western Europe.
My paper discusses the institutionalized anthropological and ethnographic research agenda in Romania, questioning its relationships with other social sciences in the context of national development of ethnography as a distinct branch (e.g., from anthropology). Secondly, I argue that institutionalized ethnographic and anthropological practice in Romania during communism significantly lacked reflective assessments and development of a theoretical corpus.
Toward a Pedagogy for Consumer Anthropology: Method, Theory, Marketing
Authors: Morais Robert J. 
Published: January 2022

This paper focuses on teaching the application of anthropology in business to marketing students. It begins with the premise that consumer marketers have long used ethnography as a component of their qualitative market research toolkit to inform their knowledge about and empathy for consumers. A question for market research educators who include ethnography in their curricula is if and how to teach the richness of anthropologically based approaches, especially given a decoupling of ethnographic method from anthropological theory in much consumer research practice. This discussion might also resonate with anthropology educators who are interested in the ways anthropology is applied in commercial settings. As a demonstration of a teaching mode rather than a research report, this paper describes how a consumer anthropology market research project is used experientially in the classroom to help marketing students learn and appreciate the application of both anthropological method and theory for brand-building. Included is a summary of an ethnographic project on Duncan Hines cake mix and an in-class student exercise during which three conceptual ‘jumping off’ points from anthropological theory were used to generate marketing initiatives.