bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Rational Design and Atroposelective Synthesis of Axially Chiral C2‐Arylpyrrole‐Derived Amino Alcohols
Authors: Han Tian‐Jiao , Zhang Zheng‐Xu , Wang Min‐Can , Xu Li‐Ping , Mei Guang‐Jian 
Published: June 2022

AbstractAxially chiral biaryl diols have achieved great success in asymmetric catalysis. By contrast, axially chiral biaryl amino alcohols are far less developed. Herein, we have rationally designed a versatileC1‐symmetric biaryl amino alcohol scaffold 1‐(1‐amino‐pyrrol‐2‐yl)naphthalen‐2‐ol (NPNOL) on the basis of axially chiral C2‐arylpyrrole framework. For its enantioselective synthesis, the chiral phosphoric acid‐catalyzed asymmetric Attanasi reaction between 1,3‐dicarbonyl compounds and azoalkenes had been established. By using this practical method, a wide range of NPNOLs were readily prepared in high yields and excellent atroposelectivities (38 examples, up to 89 % yield and 99 %ee). DFT calculations were performed to reveal the reaction mechanism and the origins of the enantioselectivity. The easy transformations of NPNOL‐derived products into organocatalysts/ligands and their preliminary applications in asymmetric catalytic reactions demonstrated the promising utility of NPNOL.
Orthogonal Access to α‐/β‐Branched/Linear Aliphatic Amines by Catalyst‐Tuned Regiodivergent Hydroalkylations
Authors: Yang Peng‐Fei , Shu Wei 
Published: June 2022

AbstractLinear, α‐branched, and β‐branched aliphatic amines are widespread in pharmaceuticals, agrochemicals, and fine chemicals. Thus, the development of direct and efficient methods to these structures in a tunable manner is highly desirable yet challenging. Herein, a catalyst‐controlled synthesis of α‐branched, β‐branched and linear aliphatic amines from Ni/Co‐catalyzed regio‐ and site‐selective hydroalkylations of alkenyl amines with alkyl halides is developed. This catalytic protocol features the reliable prediction and control of the coupling position of alkylation to provide orthogonal access to α‐branched, β‐branched and linear alkyl amines from identical starting materials. This platform unlocks orthogonal reactivity and selectivity of nickel hydride and cobalt hydride chemistry to catalytically repurpose three types of alkyl amines under mild conditions.
Circularly and Linearly Polarized Luminescence from AIE Luminogens Induced by Super‐Aligned Assemblies of Sub‐1 nm Nanowires
Authors: Rong Shujian , Shi Wenxiong , Zhang Simin , Wang Xun 
Published: June 2022

AbstractSub‐1 nm nanowires (SNWs) combine the properties of inorganic materials and polymers. They can be highly oriented through assembly, and can also be easily processed. Meanwhile, aggregation‐induced emission luminogens (AIEgens) show high potential for optical applications, but they are usually hard to process. The combination of SNWs and AIEgens can enrich both of their applications. In this study, we report that the fluorescence emission intensity of the AIEgens–SNW dispersion is dramatically enhanced due to the flexibility of SNWs. Furthermore, we fabricate two kinds of functional films with circularly polarized luminescence (CPL) and linearly polarized luminescence (LPL) activities. The construction of CPL materials didn't require any chiral chemicals. The construction of LPL materials didn't require an additional stretching process. As a result, we endowed common achiral AIEgens with a high dissymmetry factor of 0.033 and a polarization ratio of 0.44, respectively.
Fabrication and characterization of innovative chitosan/doxorubicin coated3Dprinted microneedle patch for prolonged drug delivery
Authors: Camcı Yağmur , Türk Serbülent , Gepek Engin , İyibilgin Osman , Özsoy Mehmet İskender 
Published: June 2022

AbstractIn this study, microneedles (MNs) were successfully fabricated using the 3D printing method, which provides ease of production and reproduction in the desired size. Chi/Dox MNs drug delivery systems containing doxorubicin (Dox) were successfully produced in the presence of glutaraldehyde, which was coated with chitosan (Chi) and used as a crosslinker to prolong the drug release of the produced MNs. The obtained Chi/Dox MNs drug distribution systems were characterized by SEM, FTIR, zeta, contact angle, surface energy, compression test, and drug release tests. With the SEM analyzes performed before and after coating, it was observed that the MNs were in micro dimensions, and the diameters of the MNs tips before and after coating were 41.22 μm and 54.58 μm, respectively. After the compression test, it was analyzed that each MNs could withstand a force of about 76 N. The zeta potentials of Chi and Dox solutions were measured as 8.8 and 21.5 mV, respectively. FTIR, zeta potential, contact angle, and surface energy results confirm the Dox coating and their interactions. It has been observed that Chi/Dox MNs has successfully extended drug release time without drug‐burst, and their use in skin cancer treatment is promising.
Preparation of highly selective PSf/ZnO/PEG400 tight ultrafiltration membrane for dyes removal
Authors: Aryanti Putu Teta Prihartini , Nugroho Febrianto Adi , Widiasa I Nyoman , Sutrisna Putu Doddy , Wenten I Gede 
Published: June 2022

AbstractTight ultrafiltration (UF) has increasingly been developed to overcome the low selectivity of conventional UF membranes towards soluble contaminants. In this work, a tight structure of polysulfone‐based (PSf) UF membrane was prepared by blending PSf with polyethylene glycol (PEG400), ZnO nanoparticle (ZnO‐Np), and acetone (Ac) in dimethylacetamide (DMAc). The influences of Ac/DMAc ratio (1: 15 to 1:25) and PEG400 concentration (0–25 wt%) on the binodal curve of the polymer solution, characteristics, and performances of the UF membrane were studied. The membrane performances were investigated by observing the permeate flux and dye rejection during real textile wastewater treatment. The binodal curves are close to the polymer line, which means that rapid demixing occurred after the casted solution was immersed in the coagulation bath. Based on FTIR analysis, PEG400 and ZnO‐Np were partially entrapped in the UF membrane structure. Over 90% of color removal at a permeate flux of 72 L.m−2.h−1 could be achieved when the Ac/DMAC ratio was 1:12. The tight‐UF membrane removed TDS and Naphthol AS by 74.5% and 92.8%, respectively. Since the experimental result showed a high contaminants removal, the tight‐UF could be used as clean technology to produce clean water for water reuse purposes at low energy requirements.
Characterization of complete mitochondrial genome of the common tiger, Danaus genutia (Lepidoptera: Nymphalidae: Danainae) and phylogenetic implications within the subfamily Danainae
Authors: Hao Xiang‐Yu , Ye Zi , Pan Yue , You Zi‐Han , Zhang Jing‐Feng , Li Hao‐Hang , Yuan Xiang‐Qun 
Published: June 2022

AbstractNymphalidae is the most diverse butterfly family worldwide, with more than 6000 species, whereas the mitogenomic data of nymphalid species, especially the subfamily Danainae, is still lacking for more comprehensive systematic studies. To this contribution, the complete mitogenome of Danaus genutia (Lepidoptera: Nymphalidae: Danainae) was determined via sequencing and annotating. The mitogenome in total consists of 15,255 base pairs (bp), containing 13 protein‐coding genes, 22 transfer RNAs, 2 ribosomal RNAs, and a 440‐bp noncoding A+T‐rich region. Furthermore, phylogeny of the subfamily Danainae was reconstructed applying maximum likelihood and Bayesian inference on the basis of the mitogenomic data sets. Combined with our analysis and previous studies, the genus‐level phylogenetic relationships within the subfamily Danainae are ((Tirumala + Danaus) + ((Idea + Euploea) + (Ideopsis + Parantica))). This study offers molecular information and provides a new perspective for phylogenetic research within the subfamily Danainae.
Efficient removal of nitrate and arsenic using a two‐stage biotic‐abiotic treatment system
Authors: Upadhyaya Giridhar , Raymond Will , Guarin Tatiana , Wu Pei‐Shin , Witter John , Brown Jess 
Published: June 2022

AbstractNitrate and arsenic often co‐exist in groundwater sources. Reverse osmosis, electrodialysis, and ion exchange are the commonly implemented technologies for nitrate removal. Compared to these technologies that generate high‐strength waste streams, biological treatment converts nitrate to innocuous nitrogen gas without producing a concentrated waste. When nitrate and arsenic co‐exist in a water source, combining a biotic process for nitrate removal with an abiotic process (i.e., chemical–physical process such as coagulation/flocculation) for arsenic removal may provide an effective approach for simultaneous removal of these contaminants. A 12‐month pilot study was conducted with a two‐stage, fixed‐bed biotreatment system, originally developed for nitrate removal, for simultaneous removal of nitrate and arsenic. With an empty bed contact time as low as 10 min in the bioreactor, nitrate was consistently lowered from ~35 mg/L N to <0.1 mg/L N (treatment target was <1 mg/L N), whereas arsenic was effectively lowered from ~14 μg/L to <5 μg/L. Overall, the results demonstrated efficient and resilient simultaneous removal of nitrate and arsenic using a two‐stage biotic‐abiotic treatment system.
Mineral content variations between Australian tap and bottled water in the context of urolithiasis
Authors: Kwok Michael , McGeorge Stephen , Roberts Matthew , Somani Bhaskar , Rukin Nicholas 
Published: June 2022

AbstractObjectivesThe objective of this study is to investigate the variations in mineral content of tap drinking water across major Australian cities, compared with bottled still and sparkling water, and discuss the possible implications on kidney stone disease (KSD).Materials and MethodsThe mineral composition of public tap water from 10 metropolitan and regional Australian cities was compared using the drinking water quality reports published from 2019 to 2021 by the respective water service utilities providers. Specifically, average levels of calcium, bicarbonate, magnesium, sodium, potassium, and sulphates were compared with published mineral content data from bottled still and sparkling drinking water in Australia.ResultsThe median or mean (depending on report output) mineral composition was highly variable for calcium (range 1.3 to 20.33 mg/L), magnesium (range 1.1 to 11.2 mg/L), bicarbonate (range 12 to 79 mg/L), sodium (range 3 to 47.1 mg/L), potassium (range 0.4 to 3.23 mg/L) and (sulphates range <1 to 37.4 mg/L). Calcium, magnesium and bicarbonate levels in tap water were lower than in bottled sparkling water. Consumption of 3 L/day of the most calcium rich tap water would fulfil 4.7% of the RDI, compared with 8.7% with bottled sparkling water. Consumption of 3 L of the most magnesium rich tap water would fulfil 8% of the RDI, compared with 13.6% with bottled sparkling water.ConclusionThe mineral content of tap drinking water varied substantially across major Australian city centres. Bottled sparkling water on average provided higher levels of calcium, bicarbonate and magnesium and may be preferred for prevention of calcium oxalate stones. These findings may assist counselling of patients with KSD depending on geographic location in the context of other modifiable risk factors and 24‐h urine analysis results.
International student perceptions of online medical education during the COVID‐19 epidemic
Authors: Wang Juejin , Zhang Yujie , Xia Tianxiang , Ge Yingbin , Chen Lei , Han Ying , Sun Yu , Du Jun 
Published: June 2022

AbstractThis study aimed to investigate how international students enrolled on medical and surgical bachelor's degree programs (MBBS) in China perceived online medical education course, compared to native Chinese students during the Covid‐19 pandemic. The perceptions of 38 MBBS and 31 Chinese sophomores were surveyed using the Chaoxing platform. The international student group's mean satisfaction with online teaching was 2.737 on a 5‐point scale, much lower than the Chinese students' mean score of 4.355 (p < 0.05). Similarly, the international students expressed less satisfaction than the Chinese learners with other aspects of the course, including the teacher's level, at 3.964 ± 0.818 versus 4.445 ± 0.548 (p < 0.05); curriculum organization, at 3.651 ± 0.848 versus 4.333 ± 0.568 (p < 0.05); and self‐learning level, at 3.634 ± 0.996 versus 3.686 ± 0.949 (p > 0.05), respectively. There were also noteworthy differences between the progress made by the international students in Chinese language learning, which was positively correlated with satisfaction with teaching on the online medical education (p < 0.05). The results suggest that, while online teaching was a necessary response to the Covid‐19 pandemic, satisfaction with this mode of education is lower among international students than their Chinese counterparts.
Tracing analgesic constituents from crude and vinegar‐processed resin of Boswellia carterii by integrating ultra‐performance liquid chromatography tandem mass spectrometry–based determination, analgesic evaluation in mice, and gray relationship analysis
Authors: Xie Xiaoyang , Liu Qing , Zhu Fei , Zhang Tingjun , Xu Xiangwei , Tao Yi 
Published: June 2022

AbstractThe analgesic effect of the resin of Boswellia carterii (BC) is well known; however, the constituents that contribute to the analgesic effect remain elusive. The current study integrates ultrasonic‐assisted extraction, quantitative determination, analgesic evaluation in rats, and gray relationship analysis for tracing analgesic constituents from the resin of BC. First, a robust and precise ultra‐performance liquid chromatography tandem mass spectrometry approach with multiple reaction monitoring mode was developed for the simultaneous quantification of seven major constituents in crude and vinegar‐processed resin of BC. Glycyrrhetinic acid was chosen as the internal standard. The approach showed good linearity. The intra‐ and inter‐day precisions of each constituent were within 3.0%. The recoveries of each constituent were in the range of 96.4–102.7%. The approach was then applied to determine the seven constituents in 10 batches of crude and vinegar‐processed resin of BC. Second, the analgesic effects of crude and vinegar‐processed resin of BC were assessed in mice. Third, chemometrics methods, gray relationship analysis, and partial least squares regression were employed for determining the relationship between the contents of seven constituents and their analgesic effects. 11‐Keto‐β‐boswellic acid, 3‐acetyl‐β‐boswellic acid, 3‐acetyl‐α‐boswellic acid, 3‐acetyl‐11‐keto‐β‐boswellic acid, and β‐sitosterol were identified as the key analgesic constituents of BC.
Expert consensus on the clinical application of PI3K/AKT/mTOR inhibitors in the treatment of advanced breast cancer
Authors:   The Society of Clinical Research of Oncology Medications of China Anticancer Association,   Breast Cancer Expert Committee of National Cancer Quality Control Center,   Boao Cancer Innovation Institute
Published: June 2022

AbstractPhosphoinositide 3‐kinase (PI3K)/protein kinase B (PKB or AKT)/mammalian target of rapamycin (mTOR) signaling pathway (PAM pathway) plays an important role in the development of breast cancer and are closely associated with the resistance to endocrine therapy in advanced breast cancer. Therefore, anticancer treatment targeting key molecules in this signaling pathway has become a research hotspot in recent years. Randomized clinical trials have demonstrated that PI3K/AKT/mTOR inhibitors bring significant clinical benefit to patients with advanced breast cancer, especially to those with hormone receptor (HR)‐positive, human epidermal growth factor receptor (HER) 2‐negative advanced breast cancer. Alpelisib, a PI3K inhibitor, and everolimus, an mTOR inhibitor, have been approved by FDA. Based on their high efficacy and relatively good safety profile, an expanded indication of everolimus in breast cancer has been approved by National Medical Products Administration (NMPA). Alpelisib is expected to be approved in China in the near future. The members of the consensus expert panel reached this consensus to comprehensively define the role of PI3K/AKT/mTOR signaling pathway in breast cancer, efficacy and clinical applications of PI3K/AKT/mTOR inhibitors, management of adverse reactions, and PIK3CA mutation detection, to promote the understanding of PI3K/AKT/mTOR inhibitors for Chinese oncologists, improve clinical decision‐making, and prolong the survival of target patient population.
Construction and validation of a nomogram based on N6‐Methylandenosine‐related lncRNAs for predicting the prognosis of non‐small cell lung cancer patients
Authors: Xiao Wenjing , Geng Wei , Xu Juanjuan , Huang Qi , Fan Jinshuo , Tan Qi , Yin Zhengrong , Li Yumei , Yang Guanghai , Jin Yang 
Published: June 2022

AbstractBackgroundThe N6‐methyladenosine (m6A) can modify long non‐coding RNAs (lncRNAs), thereby influencing a wide array of biological functions. However, the prognosis of m6A‐related lncRNAs (m6ARLncRNAs) in non‐small cell lung cancer (NSCLC) remains largely unknown.MethodsPearson correlation analysis was used to identify m6ARLncRNAs in 1835 NSCLC patients and with the condition (|Pearson R| > 0.4 and p < 0.001). Univariant Cox regression analysis was conducted to explore the prognostic m6ARLncRNAs. We filtered prognostic m6ARLncRNAs by LASSO regression and multivariate Cox proportional hazard regression to construct and validate an m6ARLncRNAs signature (m6ARLncSig). We analyzed the correlation between the m6ARLncSig score and clinical features, immune microenvironment, tumor mutation burden, and therapeutic sensitivity and conducted independence and clinical stratification analysis. Finally, we established and validated a nomogram for prognosis prediction in NSCLC patients.ResultsForty‐one m6ARLncRNAs were identified as prognostic lncRNAs, and 12 m6ARLncRNAs were selected to construct m6ARLncSig in the TCGA training dataset. The m6ARLncSig was further validated in the testing dataset, GSE31210, GSE37745, GSE30219, and our NSCLC samples. In terms of m6ARLncSig, NSCLC patients were divided into high‐ and low‐risk groups, with significantly different overall survival (OS), clinical features (age, sex, and tumor stage), tumor‐infiltrating immune cells, chemotherapeutic sensitivity, radiotherapeutic response, and biological pathways. Moreover, m6ARLncSig independently predicted the OS of NSCLC patients. Finally, the robustness and clinical practicability for predicting NSCLC patient prognosis was improved by constructing a nomogram containing the m6ARLncSig, age, gender, and tumor stage.ConclusionsOur study demonstrated that m6ARLncSig could act as a potential biomarker for evaluating the prognosis and therapeutic efficacy in NSCLC patients.
Variety decorative bas‐relief generation based on normal prediction and transfer
Authors: Shang Jing , Wang Meili 
Published: June 2022

AbstractAs the generation of realistic bas‐relief models from 2D images suffers from insufficient 3D depth information and severe under‐constraint, in this article, we propose a new framework for bas‐relief modeling based on 2D decorative images, which adopts conditional generative adversarial network to infer the normal information of the decorative bas‐reliefs from the greyscale information extracted from the images. For the variety of models, we extract the internal structure information through the saliency detection method based on scene perception, and use the transfer process based on the optimized texture synthesis algorithm to complete the normal editing from the source normal map to the new one, which can diversify and control the structure and detailed information of existed normal map. Finally, we adopt a bas‐relief reconstruction approach based on domain transfer recursive filter and surface from gradient to recover 2.5D information from predicted and transferred normal maps. Experiments on various model examples demonstrate the efficiency and diversity of the proposed method in reconstructing bas‐relief models from a single decorative image.
A rare new presentation of pemphigus vulgaris
Authors: Mozafari Nikoo , Ganji Raziyeh , Toossi Parviz 
Published: June 2022

AbstractWe report a new presentation for pemphigus vulgaris in a 51‐year‐old female patient that was complaining only from non‐healing foot ulcer, but unfortunately pemphigus was not confirmed and the patient lost multiple nails. This new variation is reported to increase health workers’ awareness especially in races pemphigus seems to be common.
Large infratentorial cystic oligodendroglioma in a pregnant patient: A case report of a rare presentation and literature review
Authors: Abbasi Fard Salman , Tabasi Farhad , Pourzand Pouria , Vahedi Arshia , Heravi Mehrdad , Mortazavi Martin M. 
Published: June 2022

AbstractOligodendrogliomas (ODGs) are rare brain tumors in adults, mostly presenting as a supratentorial solid mass, while less than 10% occur infratentorially. Infratentorial cystic ODGs are extremely rare. We reported a large partially cystic cerebellar ODG in a 31‐week pregnant patient with an unusual presentation and discussed the challenging management.
Targeting Pathogenic DNA and RNA Repeats: A Conceptual Therapeutic Way for Repeat Expansion Diseases
Authors: Guo Pei , Han Da 
Published: June 2022

AbstractExpansions of short tandem repeats (STRs) in the human genome cause nearly 50 neurodegenerative diseases, which are mostly inheritable, nonpreventable and incurable, posing as a huge threat to human health. Non‐B DNAs formed by STRs are thought to be structural intermediates that can cause repeat expansions. The subsequent transcripts harboring expanded RNA repeats can further induce cellular toxicity through forming specific structures. Direct targeting of these pathogenic DNA and RNA repeats has emerged as a new potential therapeutic strategy to cure repeat expansion diseases. In this conceptual review, we first introduce the roles of DNA and RNA structures in the genetic instabilities and pathomechanisms of repeat expansion diseases, then describe structural features of DNA and RNA repeats with a focus on the tertiary structures determined by X‐ray crystallography and solution nuclear magnetic resonance spectroscopy, and finally discuss recent progress and perspectives of developing chemical tools that target pathogenic DNA and RNA repeats for curing repeat expansion diseases.
A behaviour‐based coding tool for assessing supervisors' adherence and competence: Findings from a motivational interviewing implementation study
Authors: Beckman Maria , Alfonsson Sven , Rosendahl Ingvar , Berman Anne H. , Lindqvist Helena 
Published: June 2022

AbstractSupervision seems to be an essential part of therapist training and thus also of implementing evidence‐based practices. However, there is a shortage of valid and reliable instruments for objective assessment of supervision competence that include both global measures and frequency counts of behaviour—two essential aspects of supervisory competence. This study tests the internal consistency and inter‐rater reliability of an assessment tool that includes both these measures. Additionally, strategies and techniques used by 10 supervisors in 35 Motivational interviewing supervision sessions are described. Codings were conducted after two separate coding training sessions. The internal consistency across the global measures was acceptable (α = 0.70; 0.71). After the second training, the inter‐rater reliabilities for all frequency counts were in the moderate to good range, except for two that were in the poor range; inter‐rater reliability for one of the four global measures was in the moderate range, and three were in the poor range. A prerequisite for identifying specific supervisor skills central to the development of therapist skills, teaching these skills to supervisors and performing quality assurance of supervision, is to create instruments that can measure these behaviours. This study is a step in that direction.