bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable recovery for people and the planet through spirituality-induced connectedness in the hospitality and tourism industry
Authors: Rezapouraghdam Hamed , Karatepe Osman M. , Enea Constanta 
Published: September 2022

PurposeThis paper aims to propose a conceptual model which can be used in tourism and hospitality organizations to nurture human behavior change in favor of people and the planet's well-being.Design/methodology/approachA detailed review of the relevant theories and previous studies was conducted in this study.FindingsEight propositions have emerged in this research illustrating the mechanisms through which spiritual leadership within organizations can lead to a sustainable recovery of people and the planet during and post-pandemic era.Practical implicationsIn line with the United Nation's agenda for sustainable development goals, this paper provides important insights for managers, policymakers, and practitioners on a soft transition toward sustainable business practices as an attempt toward the social, environmental, and economic prosperity for people and the planet.Originality/valueThis research is one of the few studies exploring the contribution of spiritual leadership in tourism and hospitality organizations to the well-being of people and the planet.
Research agenda on turnaround strategies beyond systemic disruptions
Authors: Castelló-Sirvent Fernando , Roger-Monzó Vanessa 
Published: September 2022

PurposeSince the Great Financial Crisis (GFC), the shocks are getting deeper and deeper on the economy, sectors and companies. In these years, turnaround strategies have evolved and contribute to improving the agility and audacity of managers. This article studies the change in the research agenda and in the academic discourse as systemic disruptions become widespread and provides evidence on collaboration networks and publication opportunities.Design/methodology/approachThis research uses a comparative bibliometric analysis to understand the changes in the academic debate as of 2008. The core collection of Web of Science (WoS) is used and 198 articles on turnaround strategies published in journals indexed in Journal Citation Reports® (JCR) – Social Sciences Citation Index (SSCI) in areas like business, management, economics and finance during 1965–2022.FindingsThis research reveals an important intertemporal evolution between periods, both in the collaborative networks of researchers and in the journals that dominate the impact discourse. In addition, it provides evidence of the change in academic discourse, through the evolution of the topics of interest after the GFC. The results suggest publication opportunities around gaps not yet closed by the academic literature.Practical implicationsThis article allows researchers to be guided in identifying gaps that have not yet been closed. In addition, this research has important managerial implications, since it guides and advises journal editors on new emerging issues.Originality/valueThis document offers a global vision on the subject of study and an understanding of the development of the discourse of the academy.
Wild bee communities benefit from temporal complementarity of hedges and flower strips in apple orchards
Authors: von Königslöw Vivien , Fornoff Felix , Klein Alexandra‐Maria 
Published: September 2022

Abstract

Wild bees importantly pollinate both crop and wild plants. Yet, in intensive agricultural landscapes, wild bees are rare due to resource limitations of nectar and pollen. Flower strips and hedges are often used as resource enhancements for wild bees to overcome this shortage, but provide floral resources only during specific time periods. To sustain diverse and stable bee communities, bee‐attractive flowers need to be available during the entire growing season. This may be achieved by combining flower strips and hedges to complement each other and provide continuous floral resources.

Over three subsequent years, we compared the phenology of flower and wild bee communities in perennial flower strips, hedges and improved hedges (complemented with a sown herb layer) in conventional apple orchards in Southern Germany, a pollination‐dependent crop system.

Hedges provided floral resources in the early season while the flower strips took over later in the season.

Bees visited the hedges mostly from March to June, whereas they visited the flower strips from June to August in the first year, and in the second year already from April onwards. Flower strips were visited with an overall higher abundance and species richness than both the hedges and the improved hedges.

Synthesis and application. For enhancing wild bees in intensive apple orchards, hedges and perennial flower strips are complementary in providing flower resources. Yet, flower strips bloom more constantly and during periods of flower scarcity, and thus attract a higher diversity of bees than hedges. Perennial flower strips of different age classes should be preferred over annual strips, at best in a network with some well‐maintained hedges, as perennial flower strips of different age attract different bee communities and thus potentially a higher bee diversity on the landscape level.
Exercise during pregnancy for preventing gestational diabetes mellitus and hypertensive disorders: An umbrella review of randomised controlled trials and an updated meta‐analysis
Authors: Martínez‐Vizcaíno Vicente , Sanabria‐Martínez Gema , Fernández‐Rodríguez Rubén , Cavero‐Redondo Iván , Pascual‐Morena Carlos , Álvarez‐Bueno Celia , Martínez‐Hortelano José Alberto 
Published: September 2022

AbstractObjectiveThis study aimed to provide, through an umbrella review, an overview of the effect of single exercise interventions during pregnancy on gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP). Also, to update the current evidence through an updated meta‐analysis.DesignUmbrella review.SettingPubMed, EMBASE, Web of Science, Cochrane database of systematic reviews, Epistemonikos, SPORTDiscus, Clinicaltrials.gov, and PROSPERO register were searched from the database inception until August 2021.PopulationPeer‐reviewed systematic reviews and meta‐analyses of randomised controlled trials (RCTs) and RCTs samples.MethodsRandom‐effects model was used to calculate relative risk with 95% confidence interval in the updated meta‐analysis. The reference category was the groups that received usual prenatal care. AMSTAR 2 and the Cochrane Collaboration tool were used to assess the quality and GRADE approach was used to assess the overall certainly of evidence.Main outcome measuresGDM and HDP relative risk.ResultsTwenty‐three systematic reviews and meta‐analyses; and 63 RCTs were included. Single exercise interventions reduced the incidence of GDM and HDP in most systematic reviews and meta‐analyses. Moreover, exercise interventions during pregnancy decrease the incidence of developing GDM and GH, particularly when they are supervised, have a low to moderate intensity level, and are initiated during the first trimester of pregnancy.ConclusionBased on the findings, obstetric and physical exercise professionals could recommend exercise interventions during pregnancy as an effective strategy to improve maternal outcomes.
A Place Where Women Thrived: UK Social Survey Official Statistics
Authors: Dobbs Joy 
Published: September 2022

Abstract
Women had a strong presence in the workforce of UK Social Survey Official Statistics from its inception. Joy Dobbs was part of a cohort of women recruited in the 1970s and 1980s as government survey statistics expanded. This cohort joined and enhanced an environment and culture that nurtured and developed female talent, including two women who became National Statistician
Necessity of performing a routine chest radiograph following the insertion of tunnelled Hickman catheter under imaging guidance: A single centre experience
Authors: Kato Kosuke , Gan Calvin , Rhodes Alexander 
Published: September 2022

AbstractIntroductionA chest radiograph has traditionally been performed following the insertion of a tunnelled Hickman catheter to immediately exclude rare but potentially serious complications such as pneumothorax and haemothorax and confirm appropriate positioning of the catheter tip. The value of completing the routine chest radiograph has been questioned when fluoroscopic image may be easily obtained in the angiography suite for the same purpose, and the rate of iatrogenic pneumothorax remains extremely low in the Medical literature. We describe our experience of performing Hickman catheter insertion under ultrasound and fluoroscopic guidance and whether routinely performing the chest radiograph is justifiable.MethodsA single centre retrospective review was performed of patients who received a tunnelled Hickman catheter and underwent postprocedural chest radiograph in the Interventional Radiology Department during a fifteen‐year period from August 2007 to April 2021. Patient demographics and complications were documented.ResultsDelayed iatrogenic pneumothorax was diagnosed in one asymptomatic patient (0.06%) on a chest radiograph out of 1735 patients, and they required chest tube insertion. Other complications included two cases of right common carotid artery puncture, one case of right internal jugular vein dissection and one case of left internal jugular perforation. Two patients required a repeat procedure within 24 h due to superior migration of the Hickman catheter on chest radiograph.ConclusionGiven the extremely low rate of iatrogenic pneumothorax, chest radiograph following the insertion of a tunnelled Hickman catheter under ultrasound and fluoroscopic guidance may be an unnecessary investigation unless the patient is symptomatic, or there is sufficient clinical concern.
Male genital organs of the black‐crowned dwarf marmoset (Callibella humilis)
Authors: Vieira Kássia Regina Aguiar , Weber Hiuane Araújo , de Sant’Ana Fabiano José Ferreira , Blume Guilherme Reis , Silva Felipe Ennes , Santana Marcelo Ismar S. 
Published: September 2022

AbstractThis study provides the first morphological description of the male genital organs of black‐crowned dwarf marmoset (Callibella humilis). Internal and external genital organs were similar to other species of non‐human primates. However, some shape and size differences were noted. The penile shaft was laterally flattened and comprised of two corpus cavernosus. These were split by a septum up to the level of the glans and then merged to form a single structure. The glans penis had small, keratinized spicules arising from epidermal or dermal projections. The small, fully ossified and well‐mineralized penile bone, located at the distal end of the penis, consisted of a bone matrix surrounded by sparse osteoblasts and well‐developed internal osteocytes. The penile urethra was lined with columnar pseudostratified epithelium, with areas of simple cuboidal epithelium. The testes were small relative to the body compared to other primate species. The findings of this work may support comparative studies of primate reproductive ecology.
Energizing partnerships in research‐to‐policy projects
Authors: Panter‐Brick Catherine 
Published: September 2022

AbstractOn the ground, how can research initiatives unfold to make meaningful contributions to real‐world practice and real‐time policy? This article draws on a case study evaluating an innovative program to alleviate toxic stress, boost resilience, and promote social inclusion among Syrian refugee and Jordanian nonrefugee youth. I describe the kind of project design and community engagement that animates research on stress biology and lived experiences, connecting people with humanitarian practice and policy. I highlight why and how biocultural work generates fluency in multiple forms of evidence to guide mental health interventions, reflecting on ways to anchor research in shared humanity and shared scientific purpose. I clarify what types of added value, pursued during intersectoral collaborations, help achieve plural, sustained, and inclusive contributions. This article shows how “creative relationality” can energize research‐to‐policy initiatives to bring about transformational change.
Extracellular vesicles from human urine‐derived stem cells merged in hyaluronic acid ameliorate erectile dysfunction in type 2 diabetic rats by glans administration
Authors: Zhuang Jingming , Gao Peng , Chen Haoran , Fang Zujun , Zheng Jie , Zhu Daqian , Hou Jiangang 
Published: September 2022

AbstractBackgroundThe high prevalence of erectile dysfunction (ED) in patients with type 2 diabetes mellitus (DM2) is a challenging clinical problem. Researches on extracellular vesicles from urine‐derived stem cells (USC‐EVs) have shown that they have significant therapeutic effects in a variety of diseases by injection including ED. Hyaluronic acid (HA) is especially useful for delivering bioactive molecules. This study investigated the effects and related mechanisms of local administration of human USC‐EVs combined with HA (USC‐EVs‐HA) on a rat model of DM2ED.MethodsUCSs were extracted from human urine samples and identified for preparation of the corresponding USC‐EVs. The effects of high glucose and USC‐EVs on human umbilical vein endothelial cells (HUVECs) were assessed in vitro using a CCK‐8 assay to determine cell proliferation and pick the most appropriate concentration for subsequent experiments. Scratch and tube formation assays were performed to assess the function of HUVECs. Quantitative real‐time polymerase chain reaction (PCR) was used to detect the expression of genes such as B‐cell lymphoma‐2 (Bcl‐2), Bcl‐2‐associated X protein (BAX), and superoxide dismutase‐2 (SOD2). HA, USC‐EVs, and USC‐EVs‐HA were prepared at concentrations and then administered topically to DM2ED rats multiple times. Intracavernous pressure and mean arterial pressure were measured to assess erectile function in rats. Masson, Tunel, Immunohistochemistry, and Western blot analysis were performed to assess the fibrosis and endothelial function in corpus cavernosum, respectively.ResultsCompared with the control group, the proliferation, migration ability, and tube‐forming ability of HUVECs decreased in high glucose environment, while USC‐EVs could optimize the function of HUVECs, reverse the expression of apoptotic genes, and enhance the antioxidant capacity. USC‐EVs‐HA showed improvement in ED compared to the HA and USC‐EVs groups, and the 10‐dose group was better than the 5‐dose group. Histologically, the USC‐EVs‐HA group significantly improved apoptosis, angiogenesis, and smooth muscle regeneration in the corpus cavernosum compared to the HA group.ConclusionsThe topical application of USC‐EVs‐HA in the treatment of DM2ED rats has been proved effective. The potential mechanism might to promote the proliferation of endothelial cells and smooth muscle in the corpus cavernosum, which leads to the remodeling of erectile function. And multiple dosing at intervals may make the effect more pronounced.
Full chimaeric CAR.CIK from patients engrafted after allogeneic haematopoietic cell transplant: Feasibility, anti‐leukaemic potential and alloreactivity across major human leukocyte antigen barriers
Authors: Circosta Paola , Donini Chiara , Gallo Susanna , Giraudo Lidia , Gammaitoni Loretta , Rotolo Ramona , Galvagno Federica , Capellero Sonia , Basiricò Marco , Casucci Monica , Aglietta Massimo , Ferrero Ivana , Fagioli Franca , Cignetti Alessandro , Carnevale‐Schianca Fabrizio , Leuci Valeria , Sangiolo Dario 
Published: September 2022

SummaryCytokine‐induced killer lymphocytes (CIK) are a promising alternative to conventional donor lymphocyte infusion (DLI), following allogeneic haematopoietic cell transplantation (HCT), due to their intrinsic anti‐tumour activity and reduced risk of graft‐versus‐host disease (GVHD). We explored the feasibility, anti‐leukaemic activity and alloreactive risk of CIK generated from full‐donor chimaeric (fc) patients and genetically redirected by a chimeric antigen receptor (CAR) (fcCAR.CIK) against the leukaemic target CD44v6. fcCAR.CIK were successfully ex‐vivo expanded from leukaemic patients in complete remission after HCT confirming their intense preclinical anti‐leukaemic activity without enhancing the alloreactivity across human leukocyte antigen (HLA) barriers. Our study provides translational bases to support clinical studies with fcCAR.CIK, a sort of biological bridge between the autologous and allogeneic sources, as alternative DLI following HCT.
Metformin and simvastatin synergistically suppress endothelin 1‐induced hypoxia and angiogenesis in multiple cancer types
Authors: Liu Jie , Wang Huxia , Zhang Miao , Li Yazhao , Wang Ruiqi , Chen He , Wang Bo , Gao Xiaoqian , Song Shaoran , Wang Yaochun , Ren Yu , Li Juan , Liu Peijun 
Published: September 2022

AbstractMultiple cancers have been reported to be associated with angiogenesis and are sensitive to anti‐angiogenic therapies. Vascular normalization, by restoring proper tumor perfusion and oxygenation, could limit tumor cell invasiveness and improve the effectiveness of anticancer treatments. However, the underlying anticancer mechanisms of antiangiogenic drugs are still unknown. Metformin (MET) and simvastatin (SVA), two metabolic‐related drugs, have been shown to play important roles in modulating the hypoxic tumor microenvironment and angiogenesis. Whether the combination of MET and SVA could exert a more effective antitumor effect than individual treatments has not been examined. The antitumor effect of the synergism of SVA and MET was detected in mouse models, breast cancer patient‐derived organoids, and multiple tumor cell lines compared with untreated, SVA, or MET alone. RNA sequencing revealed that the combination of MET and SVA (but not MET or SVA alone) inhibited the expression of endothelin 1 (ET‐1), an important regulator of angiogenesis and the hypoxia‐related pathway. We demonstrate that the MET and SVA combination showed synergistic effects on inhibiting tumor cell proliferation, promoting apoptosis, alleviating hypoxia, decreasing angiogenesis, and increasing vessel normalization compared with the use of a single agent alone. The MET and SVA combination suppressed ET‐1‐induced hypoxia‐inducible factor 1α expression by increasing prolyl hydroxylase 2 (PHD2) expression. Furthermore, the MET and SVA combination showed a more potent anticancer effect compared with bosentan. Together, our findings suggest the potential application of the MET and SVA combination in antitumor therapy.
Endocrine complications after hematopoietic stem cell transplantation during childhood—Results from a close follow‐up in a cohort of 152 patients
Authors: Figueiredo Ana Abrantes , Cavaco Daniela , Damásio Inês , Maciel Joana , Pinheiro Sara , Donato Sara , Simões‐Pereira Joana 
Published: September 2022

AbstractContextHaematopoietic stem cell transplantation (HSCT) is a therapeutic option for numerous haematologic diseases and solid tumours. Increasing indications for HSCT and reduction in associated mortality have been raising the number of paediatric HSCT survivors and their long‐term toxicities.ObjectiveTo characterize the endocrine disorders developed after HSCT.Design and PatientsRetrospective analysis of 152 patients submitted to HSCT in paediatric age with at least 24 months of follow‐up at our endocrine late‐effects clinics.ResultsPatients were followed up for 9.9 (interquartile range [IQR]: 12.2) years. The median age at HSCT was 7.5 (IQR: 9) years. At least one endocrine complication was observed in 65.1% of the patients. Primary hypogonadism was detected in 34.2%. Female gender (p < .001), HSCT > 10 years old (p = .01) and chemotherapy before HSCT (p < .001) were identified as risk factors for developing gonadal dysfunction. Growth hormone deficiency (GHD) occurred in 23.0% with a mean stature Z‐score at diagnosis of −1.8 ± 1.4. GHD was associated with cranial (p < .001) and HSCT < 10 years old (p ≤ 0.001). Patients who were exposed to total body irradiation (TBI) were at higher risk for primary hypothyroidism (22.3%) (p = .01), thyroid nodules (17.1%) (p < .001), thyroid carcinoma (5.3%) (p < .001), dyslipidaemia (19.1%) (p < .001) and disturbance of carbohydrate metabolism (19.1%) (p < .001).ConclusionAt least one endocrine complication was diagnosed in 65.1% of patients, with gonadal dysfunction being the most prevalent. The conditioning regimen with TBI was a risk factor for the development of several endocrine disorders. This study is one of the largest series evaluating the endocrine disorders among survivors of paediatric HSCT and intends to reinforce the importance of routine follow‐up of these patients.
Epigenomic and somatic mutations of pituitary tumors with clinical and pathological correlations in 111 patients
Authors: Guaraldi Federica , Morandi Luca , Zoli Matteo , Mazzatenta Diego , Righi Alberto , Evangelisti Stefania , Ambrosi Francesca , Tonon Caterina , Giannini Caterina , Lloyd Ricardo V. , Asioli Sofia 
Published: September 2022

AbstractObjectiveTo profile clinically non‐aggressive and aggressive pituitary adenomas (PAs)/pituitary neuroendocrine tumours (PitNETs) and pituitary carcinomas for somatic mutations and epigenetic alterations of genes involved in cell proliferation/differentiation, microRNAs (miRNA)/long noncoding RNA (LncRNA)‐post‐transcriptional regulators and therapy targets.DesignRetrospective observational study.Patients and MeasurementsA total of 64 non‐aggressive and 41 aggressive PAs/PitNETs and 6 pituitary carcinomas treated by endoscopic surgery with ≥1‐year follow‐up were included. Somatic mutations of 17 genes and DNA methylation of 22 genes were assessed. Ten normal pituitaries were used as control.ResultsWe found at least one mutation in 17 tumours, including 6/64 non‐aggressive, 10/41 aggressive PAs/PitNETs, and 1/6 pituitary carcinoma. AIP (N = 6) was the most frequently mutated gene, followed by NOTCH (4), and TP53 (3). Hypermethylation of PARP15, LINC00599, ZAP70 was more common in aggressive than non‐aggressive PAs/PITNETs (p < .05). Lower levels of methylation of AIP, GNAS and PDCD1 were detected in aggressive PAs/PITNETs than non‐aggressive ones (p < .05). For X‐linked genes, males presented higher level of methylation of FLNA, UXT and MAGE family (MAGEA11, MAGEA1, MAGEC2) genes in aggressive vs. non‐aggressive PAs/PITNETs (p < .05).In pituitary carcinomas, methylation of autosomal genes PARP15, LINC00599, MIR193 and ZAP70 was higher than in PAs/PITNETs, while X‐linked genes methylation level was lower.ConclusionsSomatic mutations and methylation levels of genes involved in cell proliferation/differentiation, miRNA/LncRNA‐post‐transcriptional regulators and targets of antineoplastic therapies are different in non‐aggressive and in aggressive PAs/PitNETs. Methylation profile also varies according to gender. Combined genetic‐epigenetic analysis, in association with clinico‐radiological‐pathological data, may be of help in predicting PA/PitNET behaviour.