bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction of Biomimetic-Responsive Nanocarriers and their Applications in Tumor Targeting
Authors: Shi Anhua , Wu Junzi , Tian Xuexia 
Published: January 2022

Backgroud:At present, tumors are leading cause of death. Biomimetic nanocarriers for precision cancer therapy are attracting increasing attention. Nanocarriers with a good biocompatible surface could reduce the recognition and elimination of nanoparticles as foreign substances by the immune system, offer specific targeting, and improve the efficacy of precision medicine for tumors, thereby providing outstanding prospects for application in cancer therapy. In particular, cell membrane biomimetic camouflaged nanocarriers have become a research hotspot because of their excellent biocompatibility, prolonged circulation in the blood, and tumor targeting.Objective:The objective of this study is to summarize the biological targeting mechanisms of different cell membraneencapsulated nanocarriers in cancer therapy. In this article, the characteristics, applications, and stages of progress of bionic encapsulated nanocarriers for different cell membranes are discussed, as are the field’s developmental prospects.Method:The findings on the characteristics of bionic encapsulated nanocarriers for different cell membranes and tumor treatment have been analyzed and summarized.Results:Biomimetic nanosystems based on various natural cell and hybrid cell membranes have been shown to efficiently control targeted drug delivery systems. They can reduce immune system clearance, prolong blood circulation time, and improve drug loading and targeting, thereby enhancing the diagnosis and treatment of tumors and reducing the spread of CTCs.Conclusion:With advances in the development of biomimetic nanocarrier DDSs, novel ideas for tumor treatment and drug delivery have been emerged. However, there are still some problems in biomimetic nanosystems. Therefore, it needs to be optimized through further research, from the laboratory to the clinic to benefit a wide range of patients.
Potential Implications of Vouacapan Compounds for Insecticidal
Activity: An In Silico Study
Authors: Ortiz-Zamora Lisset , Ferreira Jaderson V. , de Oliveira Nayana K.S. , de Molfetta Fábio A. , Hage-Melim Lorane I.S. , Fernandes Caio P. , Oliveira Anna E.M.F.M. 
Published: January 2022

Background:
From the fruits and seeds of the species of Pterodon, it
is possible to obtain two main products: essential oil and oleoresin. In oleoresin,
numerous vouacapan compounds have been demonstrated to have biological potential,
including insecticidal activity

Objective:
In silico studies were performed to identify potential candidates for natural
insecticides among the vouacapans present in the genus Pterodon.

Materials and Methods:
Molecular docking and molecular dynamics studies
were performed to analyze the interaction of vouacapan compounds with acetylcholinesterase
of Drosophila melanogaster. Pharmacokinetic parameters regarding
physicochemical properties, plasma protein binding, and activity in the central
nervous system were evaluated. The toxicological properties of the selected
molecules were predicted using malathion as the reference compound.

Results:
6α,7β-dimethoxivouacapan-17-ene (15) showed a high number of interactions
and scores in molecular docking studies. These results suggested that this
compound exhibits an inhibitory activity of the enzyme acetylcholinesterase.
This compound showed the best results regarding physicochemical properties, besides
presenting low cutaneous permeability values, suggesting null absorption.
Molecular dynamics studies demonstrated few conformational changes in the
structure of the complex formed by compound 4 and acetylcholinesterase enzyme
throughout the simulation time.

Conclusion:
It was determined that compound 4 (vouacapan 6α,7β,17β,19-tetraol)
could be an excellent candidate for usage as a natural insecticide.
Characterizing Awareness of Pre-Exposure Prophylaxis for HIV Prevention in Manila and Cebu, Philippines: Web-Based Survey of Filipino Cisgender Men Who Have Sex With Men
Authors: Restar Arjee , Surace Anthony , Adia Alexander , Goedel William , Ogunbajo Adedotun , Jin Harry , Edeza Alberto , Hernandez Laufred , Cu-Uvin Susan , Operario Don 
Published: January 2022

Background
The Philippines is experiencing an HIV crisis and is considering implementing pre-exposure prophylaxis (PrEP) as a national public health strategy for HIV prevention for cisgender men who have sex with men (cis-MSM). However, critical information on the awareness of PrEP among cis-MSM is needed to roll out this public health initiative.

Objective
This study aims to assess PrEP awareness and related correlates (ie, sociodemographic variables, social factors, and health care access and use) among Filipino cis-MSM.

Methods
We conducted a web-based survey with Filipino cis-MSM (n=179) residing in the cities of Manila and Cebu, Philippines. Multivariable analysis procedures were performed to examine the factors associated with PrEP awareness.

Results
Our sample demonstrated high awareness (134/179, 74.9%) and interest (159/179, 88.8%) in taking PrEP. The adjusted model showed that greater odds of PrEP awareness were associated with having a college education or higher versus a high school education or lower (adjusted odds ratio [aOR] 7.30, 95% CI 1.01-52.47), earning between PHP 10,000 (US $198.6) and PHP 20,000 (US $397.2) versus <PHP 10,000 (US $198.60; aOR 9.32, 95% CI 1.41-6.22), having had a prior HIV test (aOR 6.06, 95% CI 1.20-13.55), having high HIV knowledge (aOR 3.50, 95% CI 1.11-10.98), and having friends who discussed PrEP (aOR 11.17, 95% CI 2.73-14.5).

Conclusions
Our findings demonstrate that Filipino cis-MSM are aware of and interested in taking PrEP, but there is currently an unmet need for such biomedical HIV prevention technologies among this population. Incorporating PrEP education into routine HIV screening and leveraging cis-MSM social networks may be useful in optimizing potential PrEP implementation in the Philippines.
Influence of Factors Relating to Sex and Gender on Rank List Decisions and Perceptions of Residency Training: Survey Study
Authors: Gibney Ryan , Cantwell Christina , Wray Alisa , Boysen-Osborn Megan , Wiechmann Warren , Saadat Soheil , Smart Jonathan , Toohey Shannon 
Published: January 2022

Background
Females make up more than half of medical school matriculants but only one-third of emergency medicine (EM) residents. Various factors may contribute to why fewer females choose the field of EM, such as the existing presence of females in the specialty.

Objective
This study is a follow-up to previous work, and a survey is used to assess current residents’ attitudes and perceptions on various factors, including those relating to sex and gender on creating rank lists as medical students and in perceived effects on residency education.

Methods
A web-based survey consisting of Likert scale questions regarding a variety of factors influencing a student’s decision to create a rank list and in perceived effects on residency education was sent to current EM residents in 2020.

Results
Residents from 17 programs participated in the survey with an 18.2% (138/758) response rate. The most important factors in creating a rank list were the personality of residents in the program, location, and facility type. For factors specifically related to gender, respondents who answered affirmatively to whether the gender composition of residents affected the selection of a program in making a rank list were more likely to also answer affirmatively to subsequent questions related to the gender of program leadership (P<.001) and gender composition of attending physicians (P<.001). The personality of residents was also the most important factor perceived to affect residency education. For factors influencing rank list and residency education, female respondents placed higher importance on subcategories related to gender (ie, gender composition of the residents, of the program leadership, and of the attending physicians) to a significant degree compared with their male counterparts.

Conclusions
Although factors such as location and resident personality show the most importance in influencing residency selection, when stratifying based on respondent sex, females tend to indicate that factors relating to gender have more influence on rank list and residency education compared with males.
Antiplasmodial activity of faloak bark (Sterculia quadrifida, R.Br.) extract from East Nusa Tenggara, Indonesia
Authors: Tenda Priska Ernestina , Hilaria Maria , Ramadani Arba Pramundita 
Published: January 2022

The current development of antimalarial drug resistance encourages researchers to discover and develop novel antimalarials. One of its alternatives for antimalarial discovery is using medicinal plants remembering the success of artemisinin. Sterculia quardrifida R. Br. bark, locally name as faloak, is an endemic medicinal plant from East Nusa Tenggara that has been used traditionally to treat malaria. However, its antimalarial activity has not been investigated, yet. This study was aimed to evaluate the antiplasmodial activity of ethanolic extract of faloak bark against Plasmodium falciparum in vitro. Using FCR-3 P. falciparum strain, the ethanolic extract was evaluated on various concentration (1, 10, 50, and 100 μg/mL, respectively). The IC50 value was determined by the relationship between concentration and percentage of growth inhibition. The result showed that the percentage of inhibition of P. falciparum was concentration dependent, higher concentration resulting on higher percentage of inhibition with the IC50 42.399 ± 9.517 μg/mL. It can be concluded that the ethanolic extract of faloak bark have moderate antiplasmodial activity against P. falciparum in vitro.
Pigmentos fotosintéticos de Stevia rebaudiana Bert en condiciones diferenciales de luz solar y fertilización nitrogenada en invernadero
Authors: Jarma-Orozco Alfredo de Jes´ús , Cordero-Cordero Carina Cecilia , Cleves-Leguizamo José Alejandro 
Published: January 2022

Contextualización: El área de siembra del cultivo de estevia ha venido creciendo de manera significativa, debido a las nuevas tendencias de consumo de alimentos naturales, bajos en calorías. Los efectos de las altas radiaciones, debidas al cambio climático global, han evidenciado la necesidad de desarrollar nuevos estudios sobre el comportamiento fisiológico de los pigmentos fotosintéticos de las especies agrícolas.

Vacío de conocimiento: El desconocimiento del comportamiento de los cultivos de estevia frente a los cambios actuales y futuros del ambiente (principalmente ante aumentos de los niveles de radiación solar) hace que los agricultores y productores no obtengan los rendimientos esperados.

Propósito del estudio: El objetivo de este estudio fue analizar el efecto de diferentes niveles de radiación solar y de fertilización nitrogenada, en condiciones controladas, en la producción de pigmentos fotosintéticos de Stevia rebaudiana Bert.

Metodología: El ensayo se estableció mediante un diseño estadístico completamente al azar (DCA), bajo un arreglo factorial 2 x 6, y 16 repeticiones por tratamiento; el factor A correspondió a dos niveles de radiación solar incidente (300 y 1500 μmol de fotones. m-2 s-1 correspondientes al 20 % y 100 % de radiación respectivamente) y el factor B a seis dosis de nitrógeno (0, 60, 120, 180, 240 y 300 kg ha-1). Se evaluó el contenido de clorofilas a, b y total en hojas jóvenes y sanas a los ocho meses después del trasplante.

Resultados y conclusiones: Los resultados evidenciaron que los contenidos de clorofilas a, b y total fueron afectados significativamente por la radiación solar, pero no por los niveles de nitrógeno. En ambos ambientes de radiación, los contenidos de clorofila a fueron superiores a los de clorofila b. En el ambiente de menor radiación solar se presentaron los máximos contenidos de los pigmentos fotosintéticos. En el ambiente de 1500 µmol de fotones m-2 s-1, los contenidos de clorofilas a, b y total fueron menores en las plantas que no se fertilizaron.
Vaccines for gastrointestinal parasites, a pillar of preventive medicine in veterinary practice: Systematic review
Authors: Vargas Borda Lina Maria , Prieto Prieto Laura Daniela , Baquero Parra Monica María , Corredor Santamaria Wilson , Alcantara Neves Neuza Maria , Jaramillo Hernández Dumar Alexander 
Published: January 2022

Contextualization: The antiparasitic resistance caused by the indiscriminate use of anthelmintic drugs for the control of gastrointestinal parasites in production animals and pets, has become one of the biggest problems in animal health. For this reason, the use of vaccines could benefit animal health and welfare by controlling emerging zoonotic diseases and foodborne pathogens of animal origin, thus improving public health.
Knowledge gap: It is relevant for professionals in veterinary science to know the clinical trials of experimental vaccines for controlling certain gastrointestinal parasites. This way, they can be at the forefront of the next available technological products and so, be able to control this menace to the animal health and public health.
Purpose: To do a systematic review of clinical trials for experimental vaccines in production animals and pets for diseases caused by gastrointestinal parasites of relevance in animal production and/or public health. Furthermore, it presents the current gastrointestinal antiparasitic vaccines commercialized in different countries and their prophylactic efficacy.
Methodology: PRISMA protocols were followed for this systematic review. Articles were obtained from scientific databases with the following keywords: vaccines, clinical trials, commercial vaccines, parasites control, gastrointestinal nematodes, gastrointestinal cestodes, gastrointestinal protozoa, Ascaris suum, Ancylostoma caninum, Cooperia oncophora, Echinococcus granulosus, Eimeria spp., Giardia lamblia, Haemonchus contortus, Osteortagia osteortagi, Taenia solium and Teladorsagia circumcincta. Only clinical trials of gastrointestinal antiparasitic vaccines in birds, pets, pigs and ruminants were included in this analysis, as well as commercial vaccines currently available for these same parasites.
Results and conclusions: Even though there are important clinical trial studies of vaccines in these animal species (n=101) reported between 1964 to 2020, only five parasites can be prevented/controlled with commercial vaccines used in veterinary medicine: Haemonchus contortus and Echinococcus granulosus in ruminants, Taenia solium in pigs, Eimeria spp. in birds and Giardia lamblia in dogs (e.g., Cysvax™, Barbervax®, Providean® Hidatil EG95, CocciVac® and GiardiaVax™). It is expected that, with the development of bioinformatics and methodologies such as reverse vaccinology, this immunoprophylactic and immunotherapeutic range will be extended as to control these parasitic agents of great importance in human and animal health.
THE DEVELOPMENT OF MONITORING AND CONTROLLING SYSTEM OF FLUID LEVEL USING LABVIEW BASED ON MBED NXP LPC1768 MICROCONTROLLER
Authors: Zulhendri Agus , Trisanto Agus , Nasrullah Emir 
Published: January 2022

Based on retrieval and data processing need of an increasingly complex and varied, required for a device that can handle these needs, the computer-based system. The retrieval and processing of data to be read by computer must have a data acquisition system, one of them is a MBED NXP LPC1768 microcontroller. System monitoring and control of liquid levels use mbed NXP LPC1768 microcontroller as the data acquisition system and LabVIEW software as human machine interface (HMI). Data acquisition system between mbed NXP LPC1768 microcontroller using serial communication with the computer. Programming with LabVIEW software built with the blocks into a system program. The control and monitoring with LabVIEW microcontroller based can be implemented by serial communication with LabVIEW software that responds from sensor and equator can be monitoring and controlled in real time. The liquid level control was done in two ways: manually and automatically. two ways: manually and automatically. Automatic liquid level control is by setting the value to the desired level then it will work itself appliance reaches the set value. Keywords: Data acquisition system, Mbed NXP LPC1768, LabVIEW, Human machine interface, manual, automatic.
PENGATURAN BEBAN KOMPLEMEN LAMPU DAN MOTOR LISTRIK PENGGILING KOPI SEBAGAI PENSTABIL TEGANGAN MENGGUNAKAN MIKROKONTROLER ATMEGA8535 PADA PEMBANGKIT LISTRIK TENAGA MIKROHIDRO 5 KW (Study Kasus di Desa Talang Jawa Lampung Barat)
Authors: Herliansyah - - , Harahap Charles R , Raharjo Yuliarto - 
Published: January 2022

Gutters Javanese village is the village where people do not get the energy supply of electricity. People in this area make microhydro power plant, manufacture of power generation because microhydro is supported in this area are river flows from the mountains. In the study microhydro voltage control device is installed on the system controller uses ATmega8535 as the primary device. Installation of the controller circuit is due at microhydro is the case over voltage. Over voltage due to rotor rotation is over, resulting in over voltage at zero load To overcome these problems then be made to serve the load when the load shifted to zero at the expense of consumers. Complement the load is controlled by a microcontroller ATmega8535. Complement the work load placed on the system to reduce the previous voltages 310 volts to 230 volts by regulating the activation of complement load Key words: microhydro, complement Load, Load consumers.
SIMULASI SISTEM KENDALI WATER TREATMENT PADA PEMBANGKIT LISTRIK TENAGA UAP SEBALANG UNIT 5 & 6 LAMPUNG SELATAN
Authors: Yudhaemi Indra , Nasrullah Emir , Sudjarwanto Nur 
Published: January 2022

Pada penelitian ini dibuat simulasi tentang sistem kendali water treatment pada Pembangkit Listrik Tenaga Uap Sebalang unit 5 & 6 Lampung Selatan. Pembangkit Listrik Tenaga Uap bekerja dengan memanfaatkan energi tekanan uap dari proses perebusan air demineral air laut oleh batu bara untuk menggerakkan turbin dan generator yang akhirnya menghasilkan listrik. Bahan utama penghasil uap ini adalah air laut yang tentu saja memiliki kandungan kimia yang masih harus diolah dengan baik sehingga dapat menghasilkan uap yang tidak merusak logam-logam, khususnya kandungan garam yang sangat konduktif dan bersifat korosif. Oleh karena itu, sangat diperlukan suatu metode pengolahan air laut menjadi air demineral yang layak dijadikan uap bagi turbin yaitu metode pentreatmenan air (water treatment). In this research the simulation is made of water treatment control system on Steam Power Plant Unit 5 & 6 Sebalang, South Lampung. Steam Power Plant works by using the energy of the steam pressure by boiling demineralized sea water using coal to rotate a turbine and a generator, which is finally produces electricity. The main ingredient to produce this steam is sea water which still has chemical composition, which needs to be proccessed well, so the steam which is produced does not ruin metal, especially content of slat which is very conductive and corrosive. Therefore a method of proccessing salt water to be a proper demineralized water steam for generator is needed, which is called as water treatment method.
Studi Kemampuan Transfer Daya Maksimum Dengan Kendala Stabilitas Tegangan Pada Interkoneksi Sumbagsel
Authors: Wibawa Jaka , Hakim Lukmanul 
Published: January 2022

Suatu sistem interkoneksi memungkinkan suatu wilayah yang kekurangan energi listrik akan dapat terpenuhikebutuhannya dari pasokan energi listrik yang dikirimkan oleh wilayah dengan daya pembangkitan berlebih.Pengiriman daya pada sistem interkoneksi secara kontinu dengan baik memerlukan suatu sistem yang handal.Proses transfer daya antar wilayah pada sistem interkoneksi agar dapat terpenuhi dengan baik maka memerlukansuatu perencanaan dan studi tentang pengaruh perubahan beban pada sistem dengan tetap menjaga batastoleransi nilai tegangan dalam kondisi yang masih diizinkan dalam pengiriman daya.Metode yang digunakan untuk menyelesaikan aliran daya pada tugas akhir ini menggunakan solusi ContinuationPower Flow (CPF) pada toolbox PSAT 2.1.6 Matlab dengan langkah prediksi dan koreksi untuk kenaikan(faktor pengali kenaikan beban). Untuk skenario simulasi program, dipilih dengan menambahkan beban sebesarper10 MW di setiap beban baik saat luar waktu beban puncak (LWBP) maupun saat waktu beban puncak (WBP)pada sistem Lampung. Transfer daya maksimum saat LWBP dan WBP terjadi pada penambahan beban sebesar140 MW dengan nilai daya terbesar terdapat pada saluran yang menghubungkan Baturaja-Bukit Kemuning (51-53) sebesar 336,6633 MW (LWBP) dan 324,4741 MW (WBP).Kata kunci : Interkoneksi, Transfer daya, Continuation Power Flow (CPF) An interconnection system allows a region with lack of electricity supplied by the region with excess power.Power distribution on continue interconnection system in good condition requires a reliable system. The processof power transfer between regions in order to interconnect the system met with both the planning and requires astudy of the effect of changes in the load on the system while maintaining the tolerance limit voltage value in acondition that is still allowed in the delivery of power.The method used to solve power flow in this paper using the solution from Continuation Power Flow (CPF) onPSAT 2.1.6 Matlab toolbox with prediction and correction steps to determine the increase in λ (multiplier factorincrease in load). For the scenario simulation program, adding a load of 10 MW in each load at beyond the timewhen the peak load (Luar Waktu Beban Puncak/LWBP) or during peak load time (Waktu Beban Puncak/WBP)in Lampung system. Maximum power transfer occurs when LWBP and WBP on additional load of 140 MWwith the largest value of the power contained in the channel that connects Baturaja-Bukit Kemuning (51-53) of336.6633 MW (LWBP) and 324.4741 MW (WBP).Key word : interconnection, power transfer, Continuation Power Flow (CPF)