bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic review of service improvements for home enteral tube feeding in adults
Authors: Amaratunga Hasini , Bostock Kimberley , Cunich Michelle , Steffens Daniel , Carey Sharon 
Published: August 2022

AbstractBackgroundPatients receiving home enteral tube feeding (HETF) have a high risk of complications and readmission to hospital. This study aims to evaluate effectiveness of staff‐ and/or patient‐focused service‐improvement strategies on clinical, patient‐reported, and economic outcomes for patients receiving HETF across adult settings.MethodsThe search was conducted using MEDLINE, EMBASE, and CINAHL databases. Quality of studies were appraised using the Cochrane Collaboration Risk of Bias tool and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) assessment.ResultsEleven studies met the inclusion criteria. Pooled data found targeted HETF education with patients, carers, and staff significantly improved knowledge immediately after education and was sustained at 3–6 months. Multimodal interventions, including the formation of specialist HETF teams, significantly reduced complications such as infection, gastrostomy blockage, tube displacement, and feed intolerance but do not significantly reduce unplanned hospital encounters (outpatient clinic visits, hospitalizations, and emergency presentations). Owing to the high risk of bias in the included studies, there is low‐quality evidence to support staff training, patient education, and dedicated HETF teams.ConclusionThis review highlights the need for further quality research to allow higher‐level evidence for determining the usefulness of interventions aimed at improving outcomes for patients receiving HETF. Future research needs to include greater assessment of quality of life, quantification of the value of interventions in economic terms, and use of translational research frameworks. However, effective staff and patient education programs, along with comprehensive multidisciplinary care, should be considered standard care until a larger research base is developed.
Skeletal dysplasia of an adult male from medieval Łekno in Poland, Central Europe
Authors: Matczak Magdalena D. , Krenz‐Niedbała Marta , Łukasik Sylwia , Buikstra Jane E. , Wyrwa Andrzej Marek , Pearson Jessica 
Published: August 2022

AbstractThe skeletal dysplasias are a group of more than 450 heritable disorders that affect bone and cartilage, along with muscles, tendons, and ligaments. Achondroplasia is one of the most common skeletal dysplasias in both current and past populations. It can be transmitted intergenerationally, or it can result from a mutation. This paper aims to describe the lesions visible on the skeleton of a 30–45 year old male with achondroplasia, who lived during the 9th–11th centuries AD (medieval period) in Łekno, Poland. The Łekno settlement complex (Site 3) includes a cemetery with approximately 400 burials of monks and local lay people. Macroscopic examination facilitated a differential diagnosis that identified a probable case of achondroplastic dwarfism, combined with Léri–Weill dyschondrosteosis and ulnar hemimelia. This is the first case of dwarfism in the bioarchaeological literature that had been documented and visualized using 3D modelings, which were used to show quantitative differences in articular surface areas between the achondroplastic individual and contemporaries of normal stature. Ulnar hemimelia is most commonly seen today as a component of skeletal dysplasias. The right ulna of this male was significantly shorter than the right radius and the left ulna. It is probable that he had multiple skeletal dysplasia (achondroplasia, Léri–Weill dyschondrosteosis) as well as ulnar hemimelia as a component of achondroplasia. The combination of these disorders has not been previously reported in the bioarchaeological literature, and this individual is also the first case of achondroplasia and Léri–Weill dyschondrosteosis from the medieval period in Central Europe. As such, this example is used here to provide insights on a variety of different diseases, syndromes, and conditions in Polish medieval populations and that will help in future identification of rare diseases from archaeological sites.
NEIL3 promotes hepatoma epithelial–mesenchymal transition by activating the BRAF/MEK/ERK/TWIST signaling pathway
Authors: Lai Hui‐Huang , Hung Liang‐Yi , Yen Chia‐Jui , Hung Hsu‐Chin , Chen Ruo‐Yu , Ku Yu‐Chao , Lo Hang‐Tat , Tsai Hung‐Wen , Lee Yun‐Ping , Yang Tz‐Hsuan , Chen Yen‐Yu , Huang Yi‐Shuian , Huang Wenya 
Published: August 2022

AbstractHepatocellular carcinoma (HCC) is among the most prevalent visceral neoplasms. So far, reliable biomarkers for predicting HCC recurrence in patients undergoing surgery are far from adequate. In the aim of searching for genetic biomarkers involved in HCC development, we performed analyses of cDNA microarrays and found that the DNA repair gene NEIL3 was remarkably overexpressed in tumors. NEIL3 belongs to the Fpg/Nei protein superfamily, which contains DNA glycosylase activity required for the base excision repair for DNA lesions. Notably, the other Fpg/Nei family proteins NEIL1 and NEIL2, which have the same glycosylase activity as NEIL3, were not elevated in HCC; NEIL3 was specifically induced to participate in HCC development independently of its glycosylase activity. Using RNA‐seq and invasion/migration assays, we found that NEIL3 elevated the expression of epithelial–mesenchymal transition (EMT) factors, including the E/N‐cadherin switch and the transcription of MMP genes, and promoted the invasion, migration, and stemness phenotypes of HCC cells. Moreover, NEIL3 directly interacted with the key EMT player TWIST1 to enhance invasion and migration activities. In mouse orthotopic HCC studies, NEIL3 overexpression also caused a prominent E‐cadherin decrease, tumor volume increase, and lung metastasis, indicating that NEIL3 led to EMT and tumor metastasis in mice. We further found that NEIL3 induced the transcription of MDR1 (ABCB1) and BRAF genes through the canonical E‐box (CANNTG) promoter region, which the TWIST1 transcription factor recognizes and binds to, leading to the BRAF/MEK/ERK pathway‐mediated cell proliferation as well as anti‐cancer drug resistance, respectively. In the HCC cohort, the tumor NEIL3 level demonstrated a high positive correlation with disease‐free and overall survival after surgery. In conclusion, NEIL3 activated the BRAF/MEK/ERK/TWIST pathway‐mediated EMT and therapeutic resistances, leading to HCC progression. Targeted inhibition of NEIL3 in HCC individuals with NEIL3 induction is a promising therapeutic approach. © 2022 The Pathological Society of Great Britain and Ireland.
Aging and neural vulnerabilities in overeating: A conceptual overview and model to guide treatment
Authors: Jack Rejeski W. , Laurienti Paul J. , Bahrami Mohsen , Fanning Jason , Simpson Sean L. , Burdette Jonathan H. 
Published: August 2022

AbstractGiven the vulnerability of older adults to chronic disease and physical disability, coupled with the threat that obesity poses to healthy aging, there is an urgent need to understand the causes of positive energy balance and the struggle that many older adults face with intentional weight loss. This paper focuses on neural vulnerabilities related to overeating in older adults, and moderating variables that can have either favorable or unfavorable effects on these vulnerabilities. Research from our laboratory on older adults with obesity suggests that they are prone to similar neural vulnerabilities for overeating that have been observed in younger and middle‐aged populations. In addition, following brief postabsorptive states, functional brain networks both in the resting state and in response to active imagery of desired food are associated with 6‐month weight loss. Data reviewed suggest that the sensorimotor network is a central hub in the process of valuation and underscores the central role played by habits in overeating. Finally, we demonstrate how research on the neural vulnerabilities for overeating offers a useful framework for guiding clinical decision‐making in weight management.
Characterization of N‐doped carbon quantum dots synthesized by DBD‐based cold atmospheric pressure plasma jet
Authors: Mohammadzaheri Mina , Siahpoush Vahid , Asgari Asghar 
Published: August 2022

AbstractThis study develops a new approach for the synthesis of fluorescent N‐doped carbon quantum dots (CQDs), using cold atmospheric pressure plasma jet. Herein, the CQDs were synthesized with two plasma exposure times of 30 and 60 min. The UV‐Vis absorption spectrum confirms the existence of carbonic core and surface functional groups. The Fourier transform infrared spectrum shows that carbonyl groups and amide groups exist on the surface of CQDs. Depending on the plasma exposure time, the mean average sizes of CQDs are 3.63 and 5.45 nm with strong photoluminescence emission. Generally, our results indicated that using different mechanisms for plasma discharge, lead to different physical and chemical properties of produced plasma and consequently of synthesized CQDs. The synthesized N‐doped CQDs exhibited strong fluorescence and higher quantum yield compared to previous reports.
Performance evaluation of safety barriers based on multidimensional deconstruction
Authors: Kang Jian , Wang Lidan , Jin Hao , Zhang Jixin , Dai Haoyuan 
Published: August 2022

AbstractDue to the technological development of the petrochemical industry, the number of risk factors is increasing. Therefore, the prevention of fire accidents in the petrochemical industry is crucial. Safety barriers are used in many working environments to protect workers and mitigate or prevent accidents and directly serve the safety function. This paper presents a semi‐quantitative evaluation model for safety barriers using multidimensional deconstruction. We use different methods to evaluate the characteristics of safety barriers for classification and determine the control level of each barrier. We normalize the performance evaluation results of the barriers to determine the level acceptable to experts. A gas station is selected as a case study for the safety barrier performance evaluation. The results validate the effectiveness of the proposed model and provide an analytical approach for other industries.
Analgesic effect of nobiletin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve in mice
Authors: Zhu Chunhao , Tian Miaomiao , Liu Ning , Ma Lin , Lan Xiaobing , Yang Jiamei , Du Juan , Ma Hanxiang , Li Yuxiang , Zheng Ping , Yu Jianqiang , Peng Xiaodong 
Published: August 2022

AbstractNeuropathic pain is chronic pain resulting from central or peripheral nerve damage that remains difficult to treat. Current evidence suggests that nobiletin, isolated from Citrus reticulata Blanco, possesses analgesic and neuroprotective effects. However, its effect on neuropathic pain has not been reported. This study evaluated the analgesic effect of nobiletin on neuropathic pain induced by chronic constriction injury (CCI) in mice. In vivo, mice were intragastrically administered with nobiletin (30, 60, 120 mg/kg) for eight consecutive days, respectively. Our study indicated that nobiletin ameliorated mechanical allodynia, cold allodynia and thermal hyperalgesia on CCI mice at doses that do not induce significant sedation. Moreover, nobiletin could ameliorate axonal and myelin injury of the sciatic nerve and further restore abnormal sciatic nerve electrical activity on CCI mice. In vitro studies indicated that nobiletin could suppress the proteins and mRNA expression of the IRF5/P2X4R/BDNF signalling pathway in fibronectin‐induced BV2 cells. Overall, our results indicated that nobiletin might exert an analgesic effect on CCI‐induced neuropathic pain in mice by inhibiting the IRF5/P2X4R/BDNF signalling pathway in spinal microglia. This study provided a novel potential therapeutic drug for neuropathic pain and new insights into the pharmacological action of nobiletin.
Framework for robust parameter design and optimization of reliability characteristics
Authors: Lv Shanshan , Li Sen , Zhao Yichen , Wang Guodong 
Published: August 2022

AbstractTo achieve better product quality, the dual‐response surface has been widely used to simultaneously achieve targets for the mean and reduced variance. The general assumption is that the experimental data are normally distributed without censoring. However, reliability data are usually non‐normally distributed and censored. Consequently, the classical dual‐response surface method may not be suitable for handling reliability data. This study proposed a dual‐response surface method based on robust parameter design (RPD) for reliability data. First, a percentile lifetime and an interquartile range (IQR) were used for the location and dispersion effects, respectively. A two‐stage method was then developed to identify the effects of significant factors. During the first stage, the Boruta algorithm was employed for factor effect selection, and during the second stage, the least absolute shrinkage and selection operator (LASSO) dimension reduction method was used to determine the final significant factor effects. Finally, a modified standard particle swarm optimization (SPSO) algorithm was adopted to determine the optimal solution. The proposed method was demonstrated using an industrial thermostat experiment. Compared with other methods, the proposed method performed better over various warranty periods, particularly for the 10th percentile.
On analysis of entropy measures for titanium dioxide via rational curve fitting methods
Authors: Li Cheng‐Peng , Siddiqui Muhammad Kamran , Ali Parvez , Javed Sana , Hussain Mazhar , Khalid Sadia 
Published: August 2022

AbstractIn chemical graph theory, graph entropy is an essential parameter. It measures chemical graphs and complicated networks. In discrete mathematics, biology, and chemistry, graph entropy measures have specialized chemical uses. The purpose of this paper is to discuss graph entropies and the structure of Titanium dioxide (). We developed a new idea of computing entropies of titanium dioxide based on the degree of end vertices. Moreover, we have computed graph entropy indices for real systems, and made correlations with thermodynamic quantities like heat of formation and (thermodynamic) entropy. Also, curves have been fitted between entropy indices and thermodynamics properties (entropy, enthalpy) rational method using MATLAB.
Geometric evolution, electronic structure, and vibrational properties of ScGen− (n = 6–17) anion clusters: A DFT insight
Authors: Wang Haibo , Yang Jucai , Lin Lin 
Published: August 2022

AbstractA comparison of theoretical and experimental properties is the most effective strategy for determining the global minimum (GM) because there is no experimental method to directly test the GM structure of clusters by now. The molecular and electronic structures and properties of Sc‐doped germanium anion clusters were explored via quantum chemistry calculations using mPW2PLYP scheme and unprejudiced structural searching technique ABCluster. Isomers are determined by ABCluster structural searches, followed by reoptimization of a great number of candidate geometries. The simulated photoelectron spectra for the GM structures match with those measured in experiment, suggesting that the current most stable structures are existence in the experiment. The molecular structural evolution modes appear as follows: as the cluster size n increases, the growth patterns are from the Sc‐linked geometry (n = 10, 11) in which the Sc atom acts as a linker (Sc atom connects two Ge sub‐clusters) to the Sc‐encapsulated form (n = 13–17) in which the Sc atom is settled in the core of the Ge‐cage framework. Besides, the properties including stability, HOMO‐LUMO gap, charge transfer, IR, Raman, and UV–Vis spectra were calculated. The Raman spectra are red‐shifted from the Sc‐linked to Sc‐encapsulated configurations. The analyses of stability, HOMO‐LUMO gap, and UV–Vis spectra revealed that the ScGe16− nanocluster could be the most suitable building block for further development as potential optoelectronic materials such as solar cell.
Intensity Modulated Photocurrent Microspectrosopy for Next Generation Photovoltaics
Authors: Laird Jamie S. , Ravishankar Sandheep , Rietwyk Kevin J. , Mao Wenxin , Bach Udo , Smith Trevor A. 
Published: August 2022

AbstractIn this report, a large‐area laser beam induced current microscope that has been adapted to perform intensity modulated photocurrent spectroscopy (IMPS) in an imaging mode is described. Microscopy‐based IMPS method provides a spatial resolution of the frequency domain response of the solar cell, allowing correlation of the optoelectronic response with a particular interface, bulk material, specific transport layer, or transport parameter. The system is applied to study degradation effects in back‐contact perovskite cells where it is found to readily differentiate areas based on their markedly different frequency response. Using the diffusion‐recombination model, the IMPS response is modeled for a sandwich structure and extended for the special case of lateral diffusion in a back‐contact cell. In the low‐frequency limit, the model is used to calculate spatial maps of the carrier ambipolar diffusion length. The observed frequency response of IMPS images is then discussed.
Marc Biguenets Beitrag zur Berechnung der Seilnetztragwerke für die Olympischen Spiele 1972
Authors: Gade Jan , Ramm Ekkehard , Kurrer Karl‐Eugen , Bischoff Manfred 
Published: August 2022

AbstractBei der Berechnung der Seilnetztragwerke für die Überdachungen der Sportstätten für die Olympischen Spiele 1972 in München spielte ein bislang unveröffentlichtes und auch in Fachkreisen bislang weithin unbekanntes Manuskript des französischen Bauingenieurs Marc Biguenet, damals Mitarbeiter von Jörg Schlaich im Ingenieurbüro Leonhardt und Andrä, eine wesentliche Rolle. Es wird in zwei Veröffentlichungen von Klaus Linkwitz und Hans‐Jörg Schek aus 1971 zur Berechnung und Formfindung von Seilnetztragwerken erwähnt und liefert wichtige Vorarbeiten. Das Manuskript war in Archiven und Bibliotheken allerdings nicht aufzufinden und wurde dem ersten Autor nach intensiven Recherchen schließlich von Marc Biguenet persönlich zur Verfügung gestellt. Im Rahmen dieses Berichts wird der Inhalt des Manuskripts mit dem Ziel der Quellen‐ und Wissenssicherung erstmals veröffentlicht, vergleichend kommentiert und in den technikhistorischen Kontext eingebettet. Die logisch‐historischen Wurzeln der Berechnung von Seilnetztragwerken stehen im Zusammenhang mit der Entwicklungsgeschichte nichtlinearer baustatischer Theorien, dem Bau weitgespannter Hängebrücken sowie der Herausbildung computergestützter Berechnungsmethoden.
Impact of amyloid PET in the clinical care of veterans in a tertiary memory disorders clinic
Authors: Vives‐Rodriguez Ana Laura , Schiloski Kylie A. , Marin Anna , Wang Ryan , Hajos Gabor P. , Powsner Rachel , DeCaro Renée , Budson Andrew E. , Turk Katherine W. 
Published: August 2022

AbstractIntroductionWe aimed to characterize the clinical impact of amyloid PET (APET) in a veteran population with cognitive decline by comparing differences in management between those who did and did not have an APET.MethodsThis was a retrospective observational study. Poisson regressions and logistic regression were used for comparisons.ResultsOut of 565 veterans, 197 underwent APET; positivity rate was 36.55%. Having an APET was associated with longer follow‐up, and increased diagnostic variability; it was not associated with number of additional studies, cholinesterase inhibitors prescription, or referrals to research. A positive APET was associated with less diagnostic variability, fewer additional tests, greater cholinesterase inhibitor prescriptions, and more research referrals.DiscussionIn a medically complex, real‐world population, APET yielded lower positivity rates and was not associated with classical clinical utility variables when comparing patients with and without an APET. APET may be used more to “rule out” rather than to confirm Alzheimer's disease.Highlights
Amyloid PET was associated with longer follow‐up, and higher diagnostic variability.
No association was seen with cholinesterase inhibitors prescription, or referrals to research.
In complex patients, expected amyloid PET positivity rates are lower than previously described.
Amyloid PETs were used to “rule out” AD than to confirm the diagnosis of AD.
Amyloid PET ordering practices in a memory disorders clinic
Authors: Turk Katherine W. , Vives‐Rodriguez Ana , Schiloski Kylie A. , Marin Anna , Wang Ryan , Singh Prabhjyot , Hajos Gabor P. , Powsner Rachel , DeCaro Renée , Budson Andrew E. 
Published: August 2022

AbstractIntroductionThis study assessed the ordering of amyloid positron emission tomography (PET) scans in a Veterans Affairs (VA) memory disorders clinic as part of routine clinical care, with possible implications for the extent to which ordering may occur outside of the VA in the future if covered by insurance.MethodsClinical features predictive of ordering amyloid PET scans were retrospectively assessed; the percentage of patients who met appropriate use criteria were evaluated.ResultsAmong 565 veterans, 34.9% of received an amyloid PET scan and 98.0% of these were consistent with appropriate use criteria. Patients with a PET were younger and more likely to have an initial diagnosis of Alzheimer's disease (AD). Of patients without an amyloid PET scan ordered, 64.4% would have met appropriate use criteria for amyloid PET.DiscussionThe majority of scans ordered were consistent with appropriate use criteria and more patients were eligible than received a scan. The current study's findings that approximately one‐third of patients in a memory disorders clinic received an amyloid PET scan has implications for memory disorders clinics inside and outside of the US Veterans Health Administration.
Introduction: Regions of Memory in Theory
Authors: Lewis Simon , Wawrzyniak Joanna 
Published: August 2022

AbstractSetting the agenda for the chapters to come, the volume editors lay out in this chapter the importance of moving beyond the nation state in memory studies, arguing that a narrower and more specific framework than the global/universal needs to be developed. This is why they propose an alternative unit of analysis on the medium scale: the memory region, which allows for a more nuanced and accurate approach to memory processes and dynamics in various parts of the world. They emphasize connectivities between memories across national borders and cross-national orientation points in forming memories, as much as agency and subjectivity of memory actors in the construction and reconstruction of memory reference points and frameworks across borders. The authors discuss memory regions in reference to such concepts as: regimes of memory, geography of memory, area studies, and travels of memory.