bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Yoga on the Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Authors: Ghazvineh Dorsa , Daneshvar Mojtaba , Basirat Vahid , Daneshzad Elnaz 
Published: September 2022

ObjectivesYoga is a mind-body stress-relieving exercise that increases mental and physical health, which may have a role in the improvement of metabolic disorders. The present study has reviewed the effect of yoga on lipid profiles as a systematic review and meta-analysis.MethodsWe evaluated the available randomized controlled trials on the effects of yoga-based programs, and lipid profiles by searching PubMed/Medline, Scopus, Web of Science, and the Cochrane central register of control trials up to January 2022. Both fixed and random effect analyses were used to find the relationships. Subgroup analysis was performed based on the continent, duration of the included studies, gender, and health condition of participants to discover the sources of heterogeneity.ResultFifty-three studies were included in the current systematic review and meta-analysis with a total sample size of 13,191. There was a striking association between yoga and total cholesterol (−10.31 mg/dl; 95% CI: −14.16, −6.45; I2 = 82.5%, P &lt; 0.001), low-density lipoprotein cholesterol (−8.64 mg/dl; 95% CI: −12.03, −5.25; I2 = 75.0%, P &lt; 0.001), high-density lipoprotein cholesterol (1.98 mg/dl; 95% CI: 0.81, 3.14; I2 = 91.6%, P &lt; 0.001), triglycerides (−13.50 mg/dl; 95% CI: −20.09, −6.92; I2 = 90.7%, P &lt; 0.001) and very low-density lipoprotein (−3.94 mg/dl; 95%CI: −6.31, −1.56; I2 = 72.2%, P &lt; 0.001).ConclusionIt seems yoga interventions had a substantial effect on lipid profiles, however, more qualified trials or cohort studies are needed to conclude exactly.
Mapping intellectual structures and research hotspots in the application of artificial intelligence in cancer: A bibliometric analysis
Authors: Lyu Peng-fei , Wang Yu , Meng Qing-Xiang , Fan Ping-ming , Ma Ke , Xiao Sha , Cao Xun-chen , Lin Guang-Xun , Dong Si-yuan 
Published: September 2022

BackgroundArtificial intelligence (AI) is more and more widely used in cancer, which is of great help to doctors in diagnosis and treatment. This study aims to summarize the current research hotspots in the Application of Artificial Intelligence in Cancer (AAIC) and to assess the research trends in AAIC.MethodsScientific publications for AAIC-related research from 1 January 1998 to 1 July 2022 were obtained from the Web of Science database. The metrics analyses using bibliometrics software included publication, keyword, author, journal, institution, and country. In addition, the blustering analysis on the binary matrix was performed on hot keywords.ResultsThe total number of papers in this study is 1592. The last decade of AAIC research has been divided into a slow development phase (2013-2018) and a rapid development phase (2019-2022). An international collaboration centered in the USA is dedicated to the development and application of AAIC. Li J is the most prolific writer in AAIC. Through clustering analysis and high-frequency keyword research, it has been shown that AI plays a significantly important role in the prediction, diagnosis, treatment and prognosis of cancer. Classification, diagnosis, carcinogenesis, risk, and validation are developing topics. Eight hotspot fields of AAIC were also identified.ConclusionAAIC can benefit cancer patients in diagnosing cancer, assessing the effectiveness of treatment, making a decision, predicting prognosis and saving costs. Future AAIC research may be dedicated to optimizing AI calculation tools, improving accuracy, and promoting AI.
Walnut supplementation after fructose-rich diet is associated with a beneficial fatty acid ratio and increased ACE2 expression in the rat heart
Authors: Bošković Maja , Živković Maja , Koricanac Goran , Tepavcevic Snezana , Zec Manja , Debeljak-Martacic Jasmina , Stanković Aleksandra 
Published: September 2022

Increased fructose consumption has been linked with chronic inflammation and metabolic syndrome (MetS). Activation of the renin-angiotensin system (RAS) and NF-κB have been detected in MetS. Walnuts are a rich source of polyunsaturated omega-3 fatty acids (n-3 PUFA) that were suggested to exert anti-inflammatory effects related to cardio-metabolic health. We hypothesized that walnut supplementation has the capacity to revert unfavorable fructose-rich diet (FRD)-induced activation of cardiac RAS and NF-κB in male rats. Due to the lack of similar studies, we investigated the effects of walnut supplementation (6 weeks) on the expression of four RAS molecules (ACE, ACE2, AT1R, and AT2R) and NF-κB in rat heart after FRD (10% w/v, 9 weeks). In addition, we followed the changes in the n-6/n-3 PUFA ratio in the total pool of heart lipids after both treatments to elucidate the walnut effects on fatty acids in the heart. 36 animals (9 per group) participated in the experiment. FRD significantly increased the ACE protein level in the heart (p &lt; 0.001). Walnut supplementation significantly increased the ACE2 protein level in the heart of FRD (p &lt; 0.001). In addition, walnut supplementation showed a significant main effect on the arachidonic acid/eicosapentaenoic acid ratio (p = 0.004). Walnut supplementation significantly reduced this ratio, in comparison with both, the control group (C vs. FW, p &lt; 0.05) and the FRD group (F vs. FW, p &lt; 0.05). However, walnut treatment failed to revert the significant effect of fructose (p &lt; 0.001) on the elevation of NF-κB protein level. Our results suggest a beneficial effect of walnut supplementation on ACE2 protein level and n-6/n-3 PUFA level in the heart of the animal model of MetS. Such results highlight the approach of omega-3-rich walnut supplementation in the stimulation of endogenous production of favorable molecules in the heart which could be an affordable nutritional treatment formaintenance of cardio-metabolic health.
A scoping review of behavior change techniques used to promote physical activity among women in midlife
Authors: Arigo Danielle , Romano Kelly A. , Pasko Kristen , Travers Laura , Ainsworth M. Cole , Jackson Daija A. , Brown Megan M. 
Published: September 2022

Women in midlife experience health risks that could be mitigated by regular physical activity and reduced sedentary time, but this population rarely achieves physical activity levels that would protect their health. As a result, many behavioral interventions are designed to promote physical activity in this population, which are purportedly guided by theoretical models of health behavior (change) and activate an associated set of behavior change techniques (BCTs). The efficacy and effectiveness of these interventions appear to be limited, however, raising questions about their design and adaptation for women in midlife. Several aspects of these interventions are currently unclear. Specifically, which women they target (i.e., how “midlife” and “sedentary” or “inactive” are defined), which theoretical models or behavior BCTs are used, and how BCTs are activated in such interventions. A synthesis of this information would be useful as an initial step toward improving physical activity interventions for this at-risk group, and thus, represented the goal of the present scoping review. Eligibility required publication in a peer-reviewed journal in English between 2000 and 2021, inclusion of only women in midlife who did not have any medical or other restrictions on their physical activity (e.g., cancer diagnosis), and free-living physical activity or sedentary behavior as the target outcome (with associated assessment). Of the 4,410 initial results, 51 articles met inclusion criteria, and these described 36 unique interventions. More than half of the articles (59%) named an underlying theoretical model and interventions included an average of 3.76 identifiable BCTs (range 1–11). However, descriptions of many interventions were limited and did not provide enough detail to determine whether or how specific BCTs were activated. Interventions also used a wide range of inclusion criteria for age range and starting activity level, which has implications for targeting/tailoring and effectiveness, and many interventions focused on marginalized populations (e.g., women from racial/ethnic minority backgrounds, those un- or under-insured). The present review identifies some strengths and highlights important limitations of existing literature, as well as key opportunities for advancing the design and potential utility of physical activity interventions for women in midlife.Systematic review registrationhttps://osf.io/g8tuc.
Research trends and hotspot analysis of age-related hearing loss from a bibliographic perspective
Authors: Cui Qingjia , Chen Na , Wen Cheng , Xi Jianing , Huang Lihui 
Published: September 2022

BackgroundUp-to-date information about the trends of age-related hearing loss (ARHL) and how this varies between countries is essential to plan for an adequate health-system response. Therefore, this study aimed to assess the research hotpots and trends in ARHL and to provide the basis and direction for future research.Materials and methodsThe Web of Science Core Collection database was searched and screened according to the inclusion criteria during 2002–2021. Bibliometric analyses were conducted by CiteSpace (Chaomei Chen, Drexel University, Philadelphia, PA, United States) software and VOSviewer (Center for Science and Technology Studies, Leiden University, Leiden, The Netherlands) software.ResultsThe query identified 1,496 publications, which showed a growth trend of this filed. These publications were from 62 countries, the United States of America (United States) showed its tremendous impact on this field in publication outputs, total citations, and international collaborations, China following in second. The Journal of Hearing Research was the most productive journal. Weijia Kong published the most papers, and the most productive institution was Washington University. The keyword “presbycusis” ranked first in research frontiers and appeared earlier, and the keywords “age-related hearing loss,” “risk,” “dementia,” “auditory cortex,” “association,” and “decline” began to appear in recent years.ConclusionThe annual number of publications has grown rapidly in the past two decades and will continue to grow. Epidemiological investigation and laboratory research are lasting hot spots, besides future research will focus on the association between ARHL and cognitive decline, dementia, and Alzheimer’s disease.
Prevalence of amenorrhea in elite female competitive climbers
Authors: Joubert Lanae , Warme Amity , Larson Abigail , Grønhaug Gudmund , Michael Marisa , Schöffl Volker , Burtscher Eugen , Meyer Nanna 
Published: September 2022

Elite competitive sport climbers exhibit a high strength-to-weight ratio and are reported in the literature to be lighter and leaner than their athletic counterparts. Current research regarding nutrition among climbers is sparse but suggests that they may be at high risk for low energy availability and Relative Energy Deficiency in Sport (RED-S). The prevalence of amenorrhea, one of the primary indicators of RED-S, is unknown in this athletic population. The purpose of this study was to determine the prevalence of current (previous 12 months) amenorrhea among elite level competitive sport climbers.MethodsAn anonymous online survey was distributed via email to 1,500 female climbers registered as competitors within the International Federation of Sport Climbing to assess the prevalence of amenorrhea over the past 12 months.ResultsA total of 114 female sport climbers answered all survey questions regarding menstrual function and 18 athletes (15.8%) presented with current amenorrhea. The majority of the athletes (72%; n = 82) were categorized with eumenorrhea. An additional 14 athletes (12.3%) provided information that indicated irregular cycles, but answers to all menstrual cycle questions were not congruent to elicit a classification of amenorrhea and these athletes were categorized with a menstrual status of unsure. The average BMI for climbers with eumenorrhea was 20.8 ± 1.8 kg/m2 and 19.9 ± 2.4 kg/m2 for those with amenorrhea. A higher percentage of climbers with amenorrhea revealed they currently struggle with an eating disorder compared to those without amenorrhea (13.5 vs. 22.2%, respectively).ConclusionThis study indicates that some female climbers competing at the World Cup level do have menstrual disturbances with relatively normal BMIs and some currently struggle with one or more eating disorders. Even though World Cup competitions use BMI critical margins to screen competitors, this research highlights the need for more medical supervision of competitive elite female sport climbers in order to protect their overall health, including menstrual function. Further research is required to clarify how many climbers suffer from endocrine abnormalities related to RED-S. With more scientific evidence in this area practitioners will be better equipped to educate the athlete and coach with evidence-based nutrition recommendations.
Are surgical outcomes for one level anterior decompression and fusion associated with MRI parameters for degenerative cervical myelopathy?
Authors: Qu Luqiang , Yang Shaofeng , Yuan Lijie , Niu Junjie , Song Dawei , Yang Songping , Yang Huilin , Zou Jun 
Published: September 2022

BackgroundOur study is to determine the correlation between preoperative MRI parameters of spinal cord compression and the effects of anterior surgery in patients with degenerative cervical myelopathy (DCM).Methods24 normal subjects with no evident abnormalities were selected as group A. 79 patients with DCM underwent single-segment (C4–5/C5–6) ACDF surgery formed the operation group, and separated into group B (without high signal) and group C (with high signal) according to the absence or presence of high signal in the spinal cord on preoperative T2-weighted MRI respectively. MRI parameters (MCC, maximum canal compromise; MSCC, maximum spinal cord compression; CR, spinal cord compression rate; RCSCDS, ratio of cervical spinal cord to dura sac) were measured. The JOA score was used to evaluate cervical spinal cord function and recovery rate (RR) was used to evaluate postoperative efficacy. The relationship between preoperative MRI parameters and postoperative efficacy was analyzed.ResultsThe preoperative JOA score and RR of group B were higher than that of group C. MCC and MSCC in group B were significantly lower than those in groups C. The multiple linear regression equation was the fitted postoperative JOA score = 13.371–2.940 * MCC −5.660 * RCSCDS +0.471 * preoperative JOA score. The fitted RR = 1.451–0.472 * MCC −1.313 * RCSCDS.ConclusionThe occurrence of high signal on T2-weighted images could reflect more serious spinal cord injury. The postoperative JOA score was significantly correlated with MCC, RCSCDS, and preoperative JOA score, while RR was significantly associated with MCC and RCSCDS.
A three-dimensional visualization of the full-field surgical region based on thin-slice MRI: A helpful approach for simultaneously guiding tumor resection and perforator flap elevation
Authors: Cui Lei , Jiang Wei Q. , Zhang De K. , Wang Gao F. , Han Yu D. , Pu Wen W. , Shao Yan , Guo Lin L. , Tao Ran , Han Yan 
Published: September 2022

BackgroundThe goal of the current study was to explore the application of preoperative three-dimensional reconstruction (3DR) based on thin-slice magnetic resonance imaging (MRI) in the simultaneous guidance of en bloc tumor resection and adjacent perforator flap elevation.MethodsThe prospective cohort included 35 patients diagnosed with either soft tissue sarcoma or squamous cell skin cancer between 2019 and 2021. The preoperative 3DR based on thin-slice MRI illustrated the spatial anatomical relationship among the tumor, underlying muscle, adjacent perforator vessels, and bone around the surgical region. The accuracy of preoperative imaging data was verified by intraoperative vessel dissection and postoperative pathological measurements.ResultsTumor size from 3DR data showed relatively high concordance rates with pathological measurements within the 95% limits of agreement. An average of three perforators (range: 1–7) with a mean diameter of 0.32 cm (range: 0.18–0.74 cm) from the 3DR were present in our study. The average distance between tumor boundary and perforator piercing sites on the 3DR was 2.2 cm (range: 1.2–7.7 cm). The average length of artery perforator coursing along the subcutaneous tissue was 5.8 cm (range: 3.3–25.1 cm). The mean flap harvest time was 55 mins (range: 36–97 min). The average flap size was 92.2 cm2 (range: 32–126 cm2). One perforator flap occurred distal partial necrosis.ConclusionA thorough understanding of anatomical structures in the surgical region according to full-field 3DR based on thin-slice MRI can improve the performance of radical resection of the tumor and adjacent perforator flap transfer, especially for junior surgeons with a poor experience.
Investigating the Correlation between the Microstructure and Electrical Properties of FeSbO4 Ceramics
Authors: Moraes Carlos G. P. , Matos Robert S. , Santos Cledson dos , Ţălu Ştefan , Attah-Baah John M. , Junior Romualdo S. Silva , Silva Marcelo S. da , Rezende Marcos V. S. , Silva Ronaldo S. , Ferreira Nilson S. 
Published: September 2022

FeSbO4 powder was prepared using the solid-state reaction method in this work. Afterward, the dense and porous ceramics were obtained by sintering the pressed powder calcined at temperatures of 900 and 1000 °C for 4 h. Rietveld profile analysis of the X-ray powder diffraction data showed that FeSbO4 adopts the trirutile-type structure (space group P42/mnm, with a ≅ 4.63 Å and c ≅ 9.23 Å). SEM images showed that the powder calcined at 900 °C after being sintered at 1200 °C resulted in ceramics of higher crystallinity, larger grains, and consequently, low porosity. The dielectric properties were measured in the frequency range of 10−1 Hz–1 MHz as a function of temperature (25–250 °C). The real (σ′) and imaginary (σ″) parts of the complex conductivity increase with rising annealing temperature for both samples. The real conductivity in the AC region for 𝑓 = 100 kHz was 1.59×10−6 S·cm−1 and 7.04×10−7 S·cm−1 for the ceramic samples obtained from the powder calcined at 900 (C-900) and 1000 °C (C-1000), respectively. Furthermore, the dielectric constants (k′) measured at room temperature and f=100 kHz were 13.77 (C-900) and 6.27 (C-1000), while the activation energies of the grain region were Ea = 0.53 eV and Ea = 0.49 eV, respectively. Similar activation energy (Ea = 0.52 eV and 0.49 eV) was also obtained by the brick-layer model and confirmed by the adjustment of activation energy by DC measurements which indicated an absence of the porosity influence on the parameter. Additionally, loss factor values were obtained to be equal to 3.8 (C-900) and 5.99 (C-1000) for measurements performed at 100 Hz, suggesting a contribution of the conductivity originated from the combination or accommodation of the pores in the grain boundary region. Our results prove that the microstructural factors that play a critical role in the electrical and dielectric properties are the average grain size and the porosity interspersed with the grain boundary region.
The Role of Sialic Acid and Red Blood Cells Zeta Potential in Oxygen Transport from Bloodstream to Vital Organs and Tissues: Review of Current Data
Authors: Пыко К.В. , Беспалов Ю.А. , Осочук С.С. 
Published: September 2022

Транспорт кислорода из русла крови в ткани жизненно важных органов является одним из наиболее важных факторов обеспечения энергетического баланса организма. При нарушении его развиваются изменения метаболизма и физиологического состояния организма, проявляющиеся в диапазоне от ощущения недомогания до летального исхода, что связано прежде всего с недостаточным потреблением тканями организма кислорода как конечного акцептора электрон-транспортной цепи митохондрий. Понимание и углубленное изучение этих механизмов может значительно повлиять на существующие подходы к лечению пациентов, подготовке спортсменов и разработке технологий двойного назначения, в том числе для военизированных подразделений. Одними из недостаточно полно изученных участников транспорта кислорода и энергообеспечения клеток являются сиаловые кислоты и формируемый ими ζ-потенциал эритроцитов.В обзоре рассмотрены и обобщены современные знания о синтезе, биодеградации сиаловых кислот, их роли в посттрансляционной модификации белков, клеточных и субклеточных структур, транспорте кислорода, энергопродукции и развитии в ряде случаев не совместимых с жизнью заболеваний. Представленные данные литературы являются основой для проведения экспериментальных исследований, которые могут помочь уточнить механизмы транспорта кислорода.
Oxygen transport from bloodstream to tissues is an important goal in maintaining the energy balance of the body. If this balance undergoes an extreme change, it could lead to number of pathological condition from fatigue to death because tissue has lack of oxygen as the final acceptor of the electron transport chain in the mitochondria. Understanding and researching these mechanisms could bring important changes in modern treatment guidelines, athletic training or military training and invention of dual-use technology. One of the unknown factors that has an impact on oxygen delivery is sialic acid and zeta- potential.This review examines and summarizes the current knowledge about the synthesis, biodegradation of sialic acids and the role in posttranslational modification of proteins, modification of cellular and subcellular structures, oxygen delivery, bioenergetics, organism development and how they influence the mortality rates of some diseases. The data presented are the basis for conducting experimental studies that can help to understand the mechanism of oxygen transport.
PENGEMBANGAN DESA WISATA SEBALOR MENJADI DAERAH TUJUAN WISATA
Authors: Andri Wahyudi  , Fachrul Firdaus  
Published: September 2022

Pengembangan Desa Wisata Sebalor menjadi Daerah Tujuan Wisata (DTW) tidak terlepas dari kemauan serta keterlibatan/ partisipasi masyarakat yang ada di desa tersebut secara langsung maupun tidak langsung. Penelitian ini bertujuan untuk memotret kemauan, keterlibatan/ partisipasi masyarakat dalam pengembangan Desa Wisata Sebalor menjadi Daerah Tujuan Wisata. Rumusan masalah dalam Penelitian ini adalah : Bagaimana Pengembangan Desa Wisata Sebalor menjadi Daerah Tujuan Wisata (DTW) dan juga ingin mengungkap beberapa hal yang dimungkinkan dapat menjadi faktor pendorong dan penghambat Pengembangan Desa Wisata Sebalor menjadi Daerah Tujuan Wisata (DTW) di kawasan Kecamatan Bandung Kabupaten Tulungagung. Metode penelitian dalam penelitian ini termasuk metode deskreptif sedangkan jenis penelitiannya adalah termasuk dalam penelitian kualitatif. Pengumpulan data dilakukan dengan menggunakan metode observasi, wawancara, dan dokumentasi. Subjek dalam penelitian ini adalah Pemerintah Desa Sebalor, Masyarakat Desa Sebalor, Pengunjung Kali Mas dan Watu Gedong. Selanjutnya analisa data dalam penelitian ini dilakukan dengan menggunakan analisa kualitatif dengan langkah-langkah reduksi data, penyajian data dan penarikan kesimpulan. Keabsahan data dalam penelitian ini meliputi 1) uji kredibility, 2) uji transferability, 3) uji dependability, 4) uji konfirmability.