bluuebunny/crossref_metadata_2025_split huggingface dataset:
Views, experiences and contributory factors related to medication errors associated with direct oral anticoagulants: a qualitative study with physicians and nurses
Authors: Al Rowily Abdulrhman , Aloudah Nouf , Jalal Zahraa , Abutaleb Mohammed H. , Paudyal Vibhu 
Published: June 2022

Abstract
Background
Direct oral anticoagulants (DOACs) have become preferable for the management of thromboembolic events. Recent publications have however identified high volume of medication errors related to DOACs. There is limited literature on why and how such errors occur or happen in clinical practice.

Aim
This study aimed to explore views, experiences, contributory factors related to DOACs medication errors from the perspectives of healthcare professionals.

Method
Semi-structured interviews using online videoconferencing were conducted with physicians and nurses from tertiary care hospitals in three different regions in Saudi Arabia. Questions included views, experiences and perceived factors contributing to errors. Interviews were transcribed verbatim and were thematically analyzed using MAXQDA Analytics Pro 2020 (VERBI Software).

Results
The semi-structured interviews (n = 34) included physicians (n = 20) and nurses (n = 14) until data saturation was achieved. The analysis identified five themes: Factors related to healthcare professionals (e.g. knowledge, confidence and access to guidelines); Factors related to patients (e.g. comorbidity, polypharmacy, medication review, and communication barriers); Factors related to organization (e.g. guidelines, safety culture and incidents reporting system); Factors related to the DOACs medications (e.g. lack of availability of antidotes and dosing issues); and Strategies for error prevention/mitigation (e.g. the need for professional training and routine medication review).

Conclusion
Healthcare professionals identified errors in relation to DOACs as multifactorial including their own and patient lack of knowledge, lack of clinical guidelines and organizational factors including safety culture. Medication review and reconciliation on discharge were key strategies suggested to reduce DOACs related errors. These strategies support the role of pharmacists as direct patients care providers to minimize DOACs errors.
Harnessing belowground processes for sustainable intensification of agricultural systems
Authors: Oburger Eva , Schmidt Hannes , Staudinger Christiana 
Published: June 2022

Abstract
Increasing food demand coupled with climate change pose a great challenge to agricultural systems. In this review we summarize recent advances in our knowledge of how plants, together with their associated microbiota, shape rhizosphere processes. We address (molecular) mechanisms operating at the plant–microbe-soil interface and aim to link this knowledge with actual and potential avenues for intensifying agricultural systems, while at the same time reducing irrigation water, fertilizer inputs and pesticide use. Combining in-depth knowledge about above and belowground plant traits will not only significantly advance our mechanistic understanding of involved processes but also allow for more informed decisions regarding agricultural practices and plant breeding. Including belowground plant-soil-microbe interactions in our breeding efforts will help to select crops resilient to abiotic and biotic environmental stresses and ultimately enable us to produce sufficient food in a more sustainable agriculture in the upcoming decades.
Evaluating Anthropogenic Origin of Unidentified Volatile Chemicals in the River Rhine
Authors: Ying Yangwei , van Kollenburg Geert , van den Doel André , Brekelmans Sanne , Zhou Hong , Stroomberg Gerard , Jansen Jeroen 
Published: June 2022

Abstract
Surface water of rivers like the Rhine is a highly relevant environmental and an important source of the Dutch drinking water. To improve protection of the environment and drinking water supply, it is important to have a continuous overview of the chemical composition of the river. Such an overview may be obtained with contemporary, untargeted analytical platforms like gas chromatography-mass spectrometry. Interpretation of such untargeted data is however challenged by the presence of many chemicals of natural origin. We developed a novel approach to screen for anthropogenic chemicals using non-parametric tests on the time trends of yet unidentified chemicals. The approach uses PARAFAC2 to extract unknown components present in GC–MS data and provides an assessment of whether such components may be anthropogenic. This significantly reduces screening efforts required by human laboratory staff. In total, out of twelve suspect unknown components, eleven were classified as anthropogenic, providing compelling evidence that studying unknown components can be highly valuable for regulatory bodies. This approach filters out many naturally occurring compounds, leaving more resources available for wet-lab identification of suspected anthropogenic chemicals.
Comparison of different salt solutions for density separation of conventional and biodegradable microplastic from solid sample matrices
Authors: Schütze Berit , Thomas Daniela , Kraft Martin , Brunotte Joachim , Kreuzig Robert 
Published: June 2022

AbstractMicroplastics are the new emerging pollutants ubiquitously detectable in aquatic and terrestrial ecosystems. Fate and behavior, as well as ecotoxicity, are of increasing environmental concern, particularly in sediments and soils as natural sinks. For a global environmental risk assessment, reliable and easy to apply analytical methods are mandatory to obtain comparable data. This is based on the isolation of microplastics out of the solid sample matrices prior to instrumental detection. Thus, this study provides an easy to apply approach for density separation. The technique emerged from a comparative study using different salt solutions to isolate conventional, and for the first time biodegradable, microplastics from different solid sample matrices, i.e., sand, artificial soil, and compost. Four solutions (water, sodium chloride, sodium hexametaphosphate, and sodium bromide) of different densities were applied followed by oxidizing digestion. Finally, the impact of the procedures on size and surface properties of microplastics was tested. Dependent on the sample matrix, the highest recovery rates of 87.3–100.3% for conventional polymers, and 38.2–78.2% for biodegradable polymers, were determined with sodium bromide. It could be shown that the type of solid sample matrix influences the recovery rates and has to be considered when choosing a sample preparation technique.
Graphical abstract
“For whom? By whom?”: critical perspectives of participation in ecological citizen science
Authors: Rautio Pauliina , Tammi Tuure , Aivelo Tuomas , Hohti Riikka , Kervinen Anttoni , Saari Maria 
Published: June 2022

AbstractThis paper is a search for common ground between two natural scientists, two childhood studies and education scholars and two human–animal studies or critical animal studies scholars all working within a shared citizen science project. The search takes the form of a thematic mapping of existing literature on ecological citizen science, with two questions: “Participation on whose terms?”, and “Participation for whose benefit?”. First, we draw from the field of childhood studies to show how the concept of participation can be theorized further. Second, we recontextualize ecological citizen science research from a multispecies perspective, following the non-anthropocentric turn in human and social sciences which has so far drawn limited attention both in educational research and in citizen science projects. We proceed by critically treading the blurry line between predetermined or science-led participation and emergent or participant-led research, forming a fruitful space for examining and reconceptualizing the prevailing human/nature distinction in science and pedagogy. What we end up proposing is not so much a solution to the issues we have located, but rather an invitation to consider participation as a possibility for engaging with the ongoing tensions regarding the apparatuses of power that guide the research practices, researchers’ thinking and ethics. For the democratic ethos of citizen science projects, these observations can result in an ongoing process of asking how would it be possible to make space for various knowledges to be regarded as such: How could different kinds of knowledge co-exist, potentially generating more just worlds?
Evaluation of virtual handles for dental implant manipulation in virtual reality implant planning procedure
Authors: Rantamaa Hanna-Riikka , Kangas Jari , Jordan Maarit , Mehtonen Helena , Mäkelä John , Ronkainen Kimmo , Turunen Markku , Sundqvist Osku , Syrjä Ismo , Järnstedt Jorma , Raisamo Roope 
Published: June 2022

Abstract

Purpose

Many surgical complications can be prevented by careful operation planning and preoperative evaluation of the anatomical features. Virtual dental implant planning in three-dimensional stereoscopic virtual reality environment has advantages over three-dimensional projections on two-dimensional screens. In the virtual environment, the anatomical areas of the body can be assessed and interacted with in six degrees-of-freedom. Our aim was to make a preliminary evaluation of how professional users perceive the use of the virtual environment on their field.

Methods

We prepared a novel implementation of a virtual dental implant planning system and conducted a small-scale user study with four dentomaxillofacial radiologists to evaluate the usability of direct and indirect interaction in a planning task.

Results

We found that all four participants ranked direct interaction, planning the implant placement without handles, to be better than the indirect condition where the implant model had handles.

Conclusion

The radiologists valued the three-dimensional environment for three-dimensional object manipulation even if usability issues of the handles affected the feel of use and the evaluation results. Direct interaction was seen as easy, accurate, and natural.
Dublin hospital workers’ mental health during the peak of Ireland’s COVID-19 pandemic
Authors: Brady Conan , Fenton Caoimhe , Loughran Orlaith , Hayes Blánaid , Hennessy Martina , Higgins Agnes , McLoughlin Declan M. 
Published: June 2022

Abstract
Background
Hospital-based healthcare workers have experienced significant psychological stressors during the COVID-19 pandemic.

Aim
To evaluate the mental health of hospital workers during the third wave of the COVID-19 pandemic in Dublin, Ireland.

Methods
Cross-sectional anonymous online survey of hospital workers (n = 377; 181 doctors (48.0%), 166 nurses (44.0%), 30 radiographers (8.0%)), collecting demographic information, COVID-19 exposure history and mental health measures.

Results
There were significant differences between profession groups in gender, experience, COVID-19 infection history, exposure to COVID-19 positive acquaintances, and work areas. Moderate-severe post-traumatic stress disorder (PTSD) symptoms were found in 45.1% (95% CI 40.1–50.1%) of all participants; significantly fewer doctors reported moderate-severe PTSD symptoms (26%; 95% CI 22–36%). A World Health Organisation-5 Wellbeing Index (WHO-5) score ≤ 32, indicating low mood, was reported by 52% (95% CI 47–57%) of participants; significantly fewer doctors reported low mood (46%; 95% CI 39–53%). One-week suicidal ideation and planning were reported respectively by 13% (95% CI 10–16%) and 5% (95% CI 3–7%) of participants with no between-group differences. Doctors reported significantly less moral injury than other groups. There were no significant between-group differences regarding coping styles. Work ability was insufficient in 39% (95% CI 34–44%) of staff; no between-group differences.

Conclusions
Dublin hospital workers reported high levels of PTSD symptoms, mood disturbance, and moral injury during the COVID-19 pandemic. Concerning levels of suicidal ideation and planning existed in this cohort. Differences in degrees of post-traumatic stress, moral injury, and wellbeing were found between profession groups, which should be considered when planning any supports.
The Use of a Cooling Crusher to Reduce the Temperature of Olive Paste and Improve EVOO Quality of Coratina, Peranzana, and Moresca Cultivars: Impact on Phenolic and Volatile Compounds
Authors: Nucciarelli Davide , Esposto Sonia , Veneziani Gianluca , Daidone Luigi , Urbani Stefania , Taticchi Agnese , Selvaggini Roberto , Servili Maurizio 
Published: June 2022

AbstractA new technology used to reduce the temperature of olive paste was applied to the extra virgin olive oil (EVOO) mechanical extraction process. The performance of a cooling crusher that was able to counteract the thermal increase that occurs during olive fruit grinding was analyzed to evaluate the effects on the development of volatile compounds and the concentration of hydrophilic phenols in the final product. The volatile profiles and phenolic fraction of EVOOs extracted from three different cultivars (Coratina, Peranzana, and Moresca) were positively affected by the use of lower temperatures during the crushing phase. The volatile fractions showed increases in the total aldehydes, mainly related to the concentrations of (E)-2-hexenal, and reductions in the total alcohols, mainly due to 1-penten-3-ol, 1-hexanol and (Z)-3-hexen-1-ol contents. The use of a lower temperature reduced the level of oxidative processes, protecting the phenolic compounds in the Moresca and Peranzana EVOOs by 17.8 and 12.1%, respectively.
Removal of lead ions (Pb2+) from water and wastewater: a review on the low-cost adsorbents
Authors: Chowdhury Imran Rahman , Chowdhury Shakhawat , Mazumder Mohammad Abu Jafar , Al-Ahmed Amir 
Published: June 2022

AbstractThe presence of lead compounds in the environment is an issue. In particular, supply water consumption has been reported to be a significant source of human exposure to lead compounds, which can pose an elevated risk to humans. Due to its toxicity, the International Agency for Research on Cancer and the US Environmental Protection Agency (USEPA) have classified lead (Pb) and its compounds as probable human carcinogens. The European Community Directive and World Health Organization have set the maximum acceptable lead limits in tap water as 10 µg/L. The USEPA has a guideline value of 15 µg/L in drinking water. Removal of lead ions from water and wastewater is of great importance from regulatory and health perspectives. To date, several hundred publications have been reported on the removal of lead ions from an aqueous solution. This study reviewed the research findings on the low-cost removal of lead ions using different types of adsorbents. The research achievements to date and the limitations were investigated. Different types of adsorbents were compared with respect to adsorption capacity, removal performances, sorbent dose, optimum pH, temperature, initial concentration, and contact time. The best adsorbents and the scopes of improvements were identified. The adsorption capacity of natural materials, industrial byproducts, agricultural waste, forest waste, and biotechnology-based adsorbents were in the ranges of 0.8–333.3 mg/g, 2.5–524.0 mg/g, 0.7–2079 mg/g, 0.4–769.2 mg/g, and 7.6–526.0 mg/g, respectively. The removal efficiency for these adsorbents was in the range of 13.6–100%. Future research to improve these adsorbents might assist in developing low-cost adsorbents for mass-scale applications.
Spectral analysis of multifractional LRD functional time series
Authors: Ruiz-Medina M. Dolores 
Published: June 2022

AbstractLong Range Dependence (LRD) in functional sequences is characterized in the spectral domain under suitable conditions. Particularly, multifractionally integrated functional autoregressive moving averages processes can be introduced in this framework. The convergence to zero in the Hilbert-Schmidt operator norm of the integrated bias of the periodogram operator is proved. Under a Gaussian scenario, a weak-consistent parametric estimator of the long-memory operator is then obtained by minimizing, in the norm of bounded linear operators, a divergence information functional loss. The results derived allow, in particular, to develop inference from the discrete sampling of the Gaussian solution to fractional and multifractional pseudodifferential models introduced in Anh et al. (Fract Calc Appl Anal 19(5):1161-1199, 2016; 19(6):1434–1459, 2016) and Kelbert (Adv Appl Probab 37(1):1–25, 2005).
Immersive technologies for tourism: a systematic review
Authors: Pratisto Eko Harry , Thompson Nik , Potdar Vidyasagar 
Published: June 2022

AbstractThis review provides a comprehensive view of immersive technology in tourism by critically analysing prior scholarly work. More specifically, it identifies the recent use of immersive technology in this field and the potential challenges it poses. This systematic review follows PRISMA guidelines and involves four key steps—identifying research questions, defining keywords, selecting studies based on inclusion and exclusion criteria, and synthesising results. It focuses on immersive technology in tourism-related peer-reviewed journal articles published from 2012 to 2020. The papers were selected from ten prominent journal databases. Some databases used combinations of search queries but with inclusion and exclusion criteria. This systematic review builds on the existing reviews by adding knowledge regarding state-of-the-art immersive technology usage in tourism and its integration with other technology. This review additionally identifies the potential challenges of implementing immersive technology in tourism. Finally, it presents a set of directions for future research in this space. In practice, the findings from this review can make both software developers and tourism providers aware of the potential of immersive technology in tourism. Software developers might consider appropriate designs that suit such usage, and tourism providers might consider using immersive technology to promote tourism destinations and provide a support system to maximise the benefits of immersive technology.
Albrecht Dürers Versgebet Die sieben Tagzeiten und die Tradition der deutschen Übertragungen der Patris sapientia
Authors: Kulagina Pavlina 
Published: June 2022

ZusammenfassungIm Fokus der Untersuchung stehen Albrecht Dürers Sieben Tagzeiten, eine gereimte Übersetzung des lateinischen Hymnus Patris sapientia, die im Jahr 1510 als Andachtsflugblatt gedruckt wurde. Der Beitrag verortet das Versgebet in der Tradition der deutschen Übertragungen des Hymnus, basierend auf dem Korpus neu erschlossener Textzeugen, und trägt zum besseren Verständnis von Dürers Tätigkeit als Verleger der Einblatt-Druckgraphik sowie seines Verhältnisses zur zeitgenössischen Laienfrömmigkeit bei.
Retrospective Multicenter Real-Life Study on the First-Line Treatment of Classical Hodgkin Lymphoma in Argentina
Authors: Mahuad Carolina , Victoria Otero , Laura Korin , Enriqueta Martinez , Fernando Warley , Hernán García Rivello , Nancy Cristaldo , Dana Kohan , Marta Zerga , Gonzalo Garate , de los Ángeles Vicente Repáraz María , Florencia Aizpurua , Erica Rojas Bilbao , Susana Cerana , Eugenia Funes Maria , Iliana Plaza , Cecilia Foncuberta , Anahí Vijnovich Baron , Santiago Cranco , Adriana Vitriu , Mariela Gomez , Justina Lavalle , Claudia Casali , Manuela Clavijo , Luciana Melillo , Cecilia Cabral Lorenzo Maria , Augusto Miroli , Laura Fischman , Maximiliano Pavlove , Marcela Miodosky , Silvana Cugliari 
Published: June 2022

AbstractThere are no data in Argentina on the response rates to first-line treatment of classical Hodgkin Lymphoma (cHL) outside clinical trials. A total of 498 patients from 7 public and private hospitals in Argentina were retrospectively examined. The median follow-up was 37.4 months (CI 95% 17.7–63.5). The median time from diagnosis to treatment was 22 days (IQR 14–42), which was significantly longer in public hospitals (49.3 (IC 95% 38.5–60.2) versus 32.5 (IC 95% 27–38); p = 0.0027). A total of 96.8% of patients were treated with ABVD.:84.3% achieved complete remission (CR) and 6.02% partial remission (PR), being the CR rate higher in private hospitals. End-of-treatment metabolic CR was achieved in 85.4% (n = 373). The interim PET scan was widely used in our cohort (70.5%; n = 351), but in only 23.3% (n = 116) was the treatment strategy response-adapted. The 5-year progression-free survival (PFS) was 76% (CI 95% 70–81). The 2 and 5-years-OS rates were 91% (CI 95% 88–94%) and 85% (CI 95% 80–89%), respectively. No differences in OS were found between public and private institutions (p = 0.27). This is one of the largest retrospective cHL cohorts reported. In Argentina ABVD is the chemotherapy regimen of choice and, although it is well tolerated, it is not exempt from toxicity. We showed that early initiation of treatment impacts the induction results. Although the use of PET scan is widespread, only a minority of patients was treated with respons- adapted strategies. The use of PET-guided treatment is strongly encouraged.