bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acidic Urine Is Associated With Poor Prognosis of Upper Tract Urothelial Carcinoma
Authors: Han Jang Hee , Jeong Seung-hwan , Yuk Hyeong Dong , Jeong Chang Wook , Kwak Cheol , Ku Ja Hyeon 
Published: January 2022

PurposeTo assess the prognostic role of acidic urine (low urine pH) in upper tract urothelial cancer (UTUC).Materials and MethodsWe reviewed patients enrolled in Seoul National University Prospectively Enrolled Registry for Urothelial Cancer-Upper Tract Urothelial Cancer (SUPER-UC-UTUC) who underwent surgical resection from March 2016 to December 2020 in Seoul National University Hospital (SNUH). Patients with non-urothelial cancer or those who are in condition at end-stage renal disease were excluded. Acidic urine was defined as urine pH ≤ 5.5.ResultsA total of 293 patients with a mean age of 70.7 ± 9.5 years were enrolled in this study. Pre-operative laboratory results showed a mean estimated glomerular filtration rate (eGFR) of 64.1 ± 19.2 mL/min/1.73m2 and a mean urine pH of 5.86 ± 0.66. Patients were subdivided into low (pH ≤ 5.5) and high (pH &gt; 5.5) urine pH for comparison. As a result, all variables were comparable except for the T stage, which was significantly higher in the low urine pH group (p = 0.017). Cox regression analysis was performed to assess the clinical impact of acidic urine on patient survival. Multivariate Cox regression analysis revealed that tumor multifocality (HR 2.07, p = 0.015), higher T stage (HR 1.54, p = 0.036), lymphovascular invasion (HR 1.69, p = 0.033), eGFR &lt; 60 mL/min per 1.73 m2 (HR 1.56, p = 0.017), and acidic urine (HR 1.63, p &lt; 0.01) independently decreased disease-free survival (DFS), while multifocality (HR 9.50, p &lt; 0.01), higher T stage (HR 9.51, p = 0.001) and acidic urine (HR 10.36, p = 0.004) independently reduced the overall survival (OS).ConclusionsAcidic urine is independently associated with reduced DFS and OS in UTUC. Acidic urine contributing to acidic environment may promote acquisition of agressive behavior of UTUC.
Intranasal Fentanyl for Procedural Analgesia in Preterm Infants
Authors: Cheng Charles , Tabbara Najla , Cheng Carol , Shah Vibhuti 
Published: January 2022

BackgroundDespite the availability of evidence-based analgesic strategies, neonatal pain management continues to be suboptimal. Intranasal (IN) fentanyl is an alternative pharmacotherapy for procedural pain in neonatal units. The objective was to evaluate the effectiveness and safety of IN fentanyl for procedural pain in preterm infants.MethodsA retrospective cohort study was conducted in infants who received IN fentanyl between May 2019 and December 2020 at an academic neonatal intensive care unit. Main outcome measures were pain responses, physiological parameters before and up to 60 min after IN fentanyl administration, and adverse events. Paired t-test and analysis of variance were used to compare pain scores and physiological parameters, respectively.ResultsThirteen infants received IN fentanyl on 22 occasions. Median (interquartile range [IQR]) gestational age and birthweight were 27 (25, 27.6) weeks and 850 (530, 1,030) grams, while median (IQR) post-menstrual age and weight were 30.9 (28.9, 32.9) weeks and 1,280 (945, 1,623) grams at the time of IN fentanyl administration. IN fentanyl was most used for lumbar puncture (55%) followed by insertion of epicutaneo-caval catheters (27%). There was a difference between the mean pre- and post-procedure Premature Infant Pain Profile scores of 1.3 (95% CI = 0.07, 2.5; p = 0.04). Physiological parameters did not differ before and up to 60 min post IN fentanyl administration (p &gt; 0.05). Two adverse events (one apnea and one desaturation) were noted.ConclusionIn our limited experience, IN fentanyl appears to be an alternative pharmacotherapy for procedural pain management in the absence of intravenous access in preterm infants.
Risk Factors Associated With Renal and Urinary Tract Anomalies Delineated by an Ultrasound Screening Program in Infants
Authors: Liu Yuling , Shi Hua , Yu Xiaojing , Xiang Tianchao , Fang Ye , Xie Xian , Pan Xiaofen , Li Xiaolin , Sun Zhicai , Zhang Bihong , Fu Simao , Rao Jia 
Published: January 2022

ObjectiveTo evaluate the value of ultrasound screening for congenital anomalies of the kidney and urinary tract (CAKUT) during the early postnatal period.MethodsThis is a prospective study that enrolled all neonates born from August 2019 to July 2020 at one medical center. Postnatal ultrasound screening was conducted in all neonates at 1, 3, and 6 months old, respectively. Information on antenatal detection and pregnancy was collected. We performed logistic regression analyses and established a predictive model to assess the potential risk factors of abnormal ultrasound screening results.ResultsPostnatal ultrasound scanning in 4,877 infants identified 268 cases (5.5%) of anomalies of kidney and urinary tract by primary screening and 92 cases (1.9%) by tertiary screening. A specific diagnosis was identified in 47 cases within the 6-month screening and follow-up program. Logistic regression revealed that preterm birth, oligohydramnios, antenatal ultrasound screening anomalies, and gestational hypothyroidism were independent risk factors for the early detection of CAKUT by postnatal ultrasound screening. The above factors were adopted to develop a predictive model that showed good calibration in predicting ultrasound findings of CAKUT. Decision curve analysis demonstrated good clinical utility.ConclusionsPostnatal ultrasound screening should be conducted in infants with risk factors associated with CAKUT. Further study on prenatal and fetal factors could help establish the predictive model for the early detection of CAKUT.
Relationship Dynamics of Couples Facing Advanced-Stage Parkinson’s Disease: A Dyadic Interpretative Phenomenological Analysis
Authors: Constant Emilie , Brugallé Elodie , Wawrziczny Emilie , Sokolowski Céline , Manceau Charlotte , Flinois Bérengère , Baille Guillaume , Luc Defebvre , Dujardin Kathy , Antoine Pascal 
Published: January 2022

Background/ObjectiveSeveral studies have examined the impact of Parkinson’s disease (PD) on the quality of couples’ relationships. To date, few studies have explored how couples experience their relationship dynamic by taking into account the disease stage. The objectives of this study were to understand the experience of each partner and to study the mechanisms that underlie their couple organization in the advanced stage of PD.MethodsSemistructured individual interviews conducted with fifteen patients and their partners were the subject of a dyadic interpretative phenomenological analysis.ResultsThree themes were identified from the analysis: the first, “A Closeness That Separates,” allows the identification of different patterns of interactions that lead to emotional distancing between the partners; the second, “The Adversity Is Not Unbearable, But Going It Alone Would Be,” emphasizes the importance of how the assisting partner provides support; and the third, “Be Prepared for Anything and Facing an Uncertain Future,” reveals the extent and modes of the dyadic regulation of the emotions linked to what the future may hold.ConclusionPsychological support is important to help couples express both their feelings and their respective needs in the evolving context of PD.
Bio-Psychological Predictors of Acute and Protracted Fatigue After Burns: A Longitudinal Study
Authors: Boersma-van Dam Elise , Engelhard Iris M. , van de Schoot Rens , Van Loey Nancy E. E. 
Published: January 2022

ObjectiveFatigue after burns is often attributed to the hyperinflammatory and hypermetabolic response, while it may be best understood from a bio-psychological perspective, also involving the neuro-endocrine system. This longitudinal multi-center study examined the course of fatigue up to 18 months postburn. The contribution of bio-psychological factors, including burn severity, pain, and acute PTSD symptoms, to the course and persistence of fatigue was studied in a multifactorial model.MethodsParticipants were 247 adult burn survivors. Fatigue symptoms were assessed with the Multidimensional Fatigue Inventory during the acute phase and subsequently at 3, 6, 12, and 18 months postburn, and were compared to population norms. Age, gender, burn severity, acute PTSD symptoms and pain were assessed as potential predictors of fatigue over time in a latent growth model.ResultsAt 18 months postburn, 46% of the burn survivors reported fatigue, including 18% with severe fatigue. In the acute phase, higher levels of fatigue were related to multiple surgeries, presence of pain, and higher levels of acute PTSD symptoms. Fatigue gradually decreased over time with minor individual differences in rate of decrease. At 18 months, pain and acute PTSD symptoms remained significant predictors of fatigue levels.ConclusionsProtracted fatigue after burns was found in almost one out of five burn survivors and was associated with both pain and acute PTSD symptoms. Early detection of PTSD symptoms and early psychological interventions aimed at reducing PTSD symptoms and pain may be warranted to reduce later fatigue symptoms.
Factors Related to the Length of Stay for Patients With Schizophrenia: A Retrospective Study
Authors: Cheng Peng , Wang Lirong , Xu Lizhi , Zhou Ying , Zhang Li , Li Weihui 
Published: January 2022

BackgroundThe length of stay (LOS) of patients with schizophrenia has been a wide concern of researchers. Reasonable management of the LOS to achieve a balance between quality of treatment and efficient medical source allocation has become a significant issue in clinical work in psychiatry. Figuring out the factors related to the LOS of schizophrenia patients can help optimize its management by the hospital.MethodThe essential information of patients was obtained from the electronic medical record system. The variables were divided into the following kinds: demographic, clinical, and biochemical. Univariate analysis and multivariate analysis were conducted to find the potential factors related to the LOS of schizophrenia patients. Receiver operating characteristic analyses were conducted to evaluate the accuracy of judging the LOS of the regression model.ResultA total of 1,160 patients with schizophrenia were enrolled in our research. Our results demonstrated that the status of unmarried (single, separated, divorced, or widowed) and the abnormality of thyroid-stimulating hormone (TSH) were risk factors for the longer LOS of schizophrenia patients. The area under the curve was 0.576, which meant that the regression model had a certain predictive value.ConclusionTo our knowledge, this research is the first study to analyze the effect of various factors, including the biochemical index, on the LOS of a single type of mental disorder. Marital status and TSH were proven to be related to the LOS of schizophrenia patients. The results of this study provided reference factors of LOS for clinical psychiatry, which will be helpful to the management of hospitalization and in optimizing the allocation of medical sources.
Health Literacy and Migrant Communities in Primary Health Care
Authors: Medina Patrícia , Maia Ana Catarina , Costa Andreia 
Published: January 2022

IntroductionThe promotion of health literacy of the population in a situation of migration, in the community, is a fundamental field of intervention in health promotion, for the reduction of inequalities in access to health care services. It is increasingly necessary to make health care services more equitable for migrant populations. The aim of the study was to characterize the level of health literacy of the population in a migrant situation, attending a primary health care unit in the Lisbon region, to identify priority areas for community intervention that will become the focus of intervention and contribute to the increase in the health literacy levels in this population.MethodsA cross-sectional study was carried out by applying the Health Literacy Survey (ILS-PT) to a sample of the population in a situation of migration, found by 27 participants.ResultsThe general health literacy index of the sample is inadequate (21.23 points). An analysis of the sub-indexes revealed that 75% of the participants had difficulties related to information about health care and 80% had difficulties in the field of health promotion.ConclusionsProblematic and inadequate levels of health literacy was significantly frequent among migrant population. So that enhancing health literacy among migrant is essential to reduce health inequalities to achieve better health outcomes and contribute to defense of human rights of this vulnerable population.
The Dermatological Effects and Occupational Impacts of Personal Protective Equipment on a Large Sample of Healthcare Workers During the COVID-19 Pandemic
Authors: Santoro Paolo Emilio , Borrelli Ivan , Gualano Maria Rosaria , Proietti Ilaria , Skroza Nevena , Rossi Maria Francesca , Amantea Carlotta , Daniele Alessandra , Ricciardi Walter , Potenza Concetta , Moscato Umberto 
Published: January 2022

IntroductionWorking during the Sars-CoV-2 pandemic healthcare workers (HCWs) had to wear Personal Protective Equipment (PPEs) for extended periods of time, leading to an increase in dermatological reactions. The study evaluates the prevalence of adverse skin reactions to PPEs among Italian healthcare workers during the COVID-19 pandemic, and aims to determine whether prolonged PPEs usage poses a significant occupational health risk, by measuring the loss of work days and the eligibility of workers that requested health surveillance due to dermatological PPEs reactions.Materials and MethodsAn online ad hoc questionnaire was administered to a sample of Italian HCWs. Questions verted on sociodemographic characteristics, PPEs usage, and occupational well-being. Descriptive analyses and logistic regressions were performed to explore possible associations between variables.ResultsTwo types of PPEs, Gloves and Masks, were tested. The sample included 1,223 interviewed HCWs, 1,184 gave their consent for participation. A total of 90 medical surveillance visits were requested due to PPEs related dermatological issues: in 30 cases were recognized limitations in working duties and in one case the worker was deemed not fit to keep working. Furthermore, 25 workers had a loss of occupational days due to dermatological issues. A statistically significant correlation was observed with being a nurse or midwife (OR = 1.91, IC = 1.38–2.63, p &lt; 0.001), and being female (OR = 2.04, IC = 1.49–2.78, p &lt; 0.001), which acted as risk factors.DiscussionThe enhanced protection measures put in place during the COVID-19 pandemic, highlight the importance of occupational dermatology. This study could contribute to assess the issue, aiming to develop better prevention strategies in the workplace in order to improve well-being of HCWs and reduce the impact of dermatological adverse reactions to PPEs.
To Be or Not to Be Mesophilic, That Is the Question for Aeromonas salmonicida
Authors: Vincent Antony T. , Charette Steve J. 
Published: January 2022

The bacterium Aeromonas salmonicida has long been known to be one of the most feared pathogens in fish farming. However, the more we discover about this bacterial species, the more we question whether it is really exclusively an aquatic pathogen. In recent years, it has become obvious that this bacterial species includes a myriad of strains with various lifestyle and ecological niches, including the well-known strict psychrophiles, the first bacteria known of the species, and the newly described mesophilic strains. The mesophiles are able to grow at low temperatures, but even better at temperatures of approximately 37 °C, which strict psychrophiles cannot do. In this perspective article, we address some aspects surrounding this dual lifestyle in A. salmonicida, including the impact of mobile genetic elements, and how future research around this bacterial species may focus on the psychrophilic/mesophilic dichotomy, which makes A. salmonicida an increasingly interesting and relevant model for the study of speciation.
Challenges of safeguarding via remote consulting during the COVID-19 pandemic: a qualitative interview study
Authors: Dixon Sharon , Frost Lucy , Feder Gene , Ziebland Sue , Pope Catherine 
Published: January 2022

BackgroundThe COVID-19 pandemic required general practice to rapidly adapt to remote consultations and assessment of patients, creating new, and exacerbating existing, vulnerabilities for many patients.AimTo explore GP perspectives and concerns about safeguarding practice during the pandemic, focusing on challenges and opportunities created by remote consultation.Design and settingQualitative interview study.MethodEighteen GPs from Oxford, London, Southampton, Liverpool, Manchester, and Reading were interviewed between June and November 2020, using a flexible topic guide and fictional vignettes to explore child and adult safeguarding scenarios. Interviews were audio-recorded, thematically coded, and analysed.ResultsGPs worried about missing observational information during remote consultations and that conversations might not be private or safe. Loss of continuity and pooled triage lists were seen as further weakening safeguarding opportunities. GPs experienced remote consulting as more ‘transactional’, with reduced opportunities to explore ‘other reasons’ including new safeguarding needs. However, they also recognised that remote consulting created opportunities for some vulnerable patients. While supporting known vulnerable patients was difficult, identifying new or unknown vulnerabilities was harder still. Most reported that remote consulting during COVID-19 was harder, riskier, and emotionally draining, contributing to increased GP anxiety and reduced job satisfaction.ConclusionThe GPs interviewed raised important concerns about how to identify and manage safeguarding in the context of remote consultations. Current guidance recommends face-to-face consultation for safeguarding concerns, but pressure to use remote forms of access (within or beyond the pandemic) and the fact that safeguarding needs may be unknown makes this an issue that warrants urgent attention.
ANALISIS DAN PERANCANGAN E-COMMERCE MENGGUNAKAN CONTENT MANAGEMENT SYSTEM WORDPRESS PADA KAYRA NU HIJAB
Authors: Hasugian Humisar , Firmanto Firmanto 
Published: January 2022

Wabah Covid-19 mengharuskan setiap orang dan badan usaha untuk merubah gaya hidup agar tetap bertahan, dampak yang paling terlihat adalah hampir semua kegiatan usaha dilakukan secara online, badan usaha yang tetap bertahan dengan gaya lama akan ketinggalan dan bahkan gulung tikar. Penjualan produk pada Kayra Nu Hijab juga mengalami dampak dimana semakin hari penjualan semakin menurun, hal ini disebabkan karena pelanggan kesulitan untuk mendapatkan informasi produk dan ketersediaan stok, dan kesulitan melakukan pesanan. Untuk mengatasi masalah tersebut dirancanglah sebuah website e-commerce memanfaatkan Content Management System WordPress dengan tambahan plugin woocommerce dan analisa bisnis menggunakan bisnis model canvas. Adapun hasil penelitian ini berupa website yang dapat diakses secara online sehingga memudahkan pelanggan pada saat melihat informasi produk, ketersediaan stok, dan dapat melakukan pesanan secara langsung tanpa datang langsung ke toko, dengan adanya hasil luaran penelitian ini diharapkan dapat meningkatkan penjualan toko dan memperluas jangkauan pasar
Udagawa Youan (1798-1846), Pioneer of Chemistry Studies in Japan from Western Sources and his Successors
Authors: Siderer Yona 
Published: January 2022

This work presents chemistry studies of the Japanese scholar Udagawa Youan (1798-1846), specifically, his pioneering book Seimi Kaiso, introduction to Chemistry, and includes a short biography of Youan. The first aim of this work is to present Youan's contribution to Western chemistry in Japan. Youan studied many Western books and listed their authors. The new terms he invented for chemistry in Japanese influenced the development of chemistry writing and application in Japan. The seven books of Seimi Kaiso that were published during 1837-1847 and republished with annotation in Japanese in 1975 are discussed in this article.
The impact of Youan' terminology on the history chemistry writing in the nineteenth and twentieth centuries is discussed. The conditions of knowledge transfer among Japanese and Western scholars were very different. Youan had severe difficulties facing the strict attitude of the Tokugawa authorities toward studying and distributing knowledge coming from foreign countries. The later development of Japanese chemistry language and studies is also described.
Factors Influencing Complaints Of Musculoskeletal Disorders (MSDS) On Female Transport Workers “Tukang Suun” At Badung-Kumbasari Market
Authors: Wira Natanagara I Gede Catur , Indonesiani Suyasning Hastiko 
Published: January 2022

Work as a transport worker or "manufacturer" is one of the jobs at risk of musculoskeletal disorders (MSDs). Complaints are caused by various factors such as age, years of service, workload, and hauling distance. This study aims to determine the effect of age, years of service, weight of load, and distance of transport with musculoskeletal complaints. The research location was carried out in Badung-Kumbasari Market, Denpasar City with a cross sectional method. The design used in this study is a cross sectional study. Data collection was carried out from September-December 2016The sample of this study was taken consecutively with 32 women as respondents. Musculoskeletal complaints were measured using a Nordic Body Maps questionnaire with a Likert scale and the factors to be studied were using questionnaires and tools that had been prepared. Data analysis used the Pearson correlation test. From the results of the study, it was found that there was a relationship between age and musculoskeletal complaints (r*=0.625; p<0.001), the relationship between years of service and musculoskeletal complaints (r*=0.683; p<0.001), the relationship between the weight of the load and musculoskeletal complaints (r*= 0.731; p<0.001) and the relationship between haulage distance and musculoskeletal complaints (r*=-0.528; p<0.001). It can be concluded that age, working period, weight of load and hauling distance affect MSDs in haulage workers and weight of load is the dominant factor. It is hoped that ergonomic weight control can reduce musculoskeletal complaints in female transport workers.