bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Morphology-Controlled Magnetic Hollow Mesoporous Fe3O4 Nanocarriers for Inhibitor Release
Authors: Liu Xin , Wang Wenjia , Li Qiushi , Xu Xuexue , Lv Yifan , Wu Sheng , Liu Yang 
Published: February 2025

Abstract
Hollow mesoporous Fe3O4 microspheres are attractive as corrosion inhibitor carriers for their structural stability, and strong superparamagnetic properties. Here the morphology-controlled magnetic hollow mesoporous Fe3O4 nanocarriers (MHMNs) with saturation magnetization of ca. 77 emu·g−1 were fabricated by self-template etching route. Serial characterization results showed that the sample (MHMNs-7.0), obtained by etching MHMNs with 7.0 mg/mL of the oxalic acid solution, presented the largest cavity volume and a rich pore structure, which promotes its high loading capacity of 77.6% for 2-mercaptobenzothiazole (MBT) inhibitor. The resulting material could be used as the carrier for loading various types of inhibitors, e.g. MBT, Ce3+, benzotriazole (BTA) and MoO42− under negative vacuum treatment. The release behavior of the obtained composite inhibitors was detected by UV-vis spectroscopy, and the inhibition behavior of the composite inhibitors for mild steel in 3.5% NaCl solution was evaluated by electrochemical impedance spectroscopy and immersion tests. The results showed that all of the ab-obtained composites presented magnetic controlled release properties and good inhibition performance. Without the external magnetic field (no MF mode), the release of MBT from MHMNs-7.0/MBT mainly involved Fickian diffusion. Under the application of a magnetic field (MF ON mode), the release behavior was dominated by a swelling mechanism, Fickian diffusion, and diffusion between magnetic particles. The nanocomposite inhibitor had good inhibition efficiency for carbon steel in 3.5% NaCl solution with a maximum of 93.66%, and its continuous release properties enabled it to exhibit long-term corrosion inhibition performance.
The relationship of neurotrophin levels with stress-induced urinary incontinence in multiparous premenopausal women
Authors: Ünal Kübranur , Latif Çöllüoğlu Musa , Erdem Elif , Özbas¸ Cansu , Özdemir Özhan 
Published: February 2025

Objective: Urinary incontinence (UI) is involuntary urine leakage, mainly due to a feeling of high pressure in the abdominal part, the immediate and urgent need for micturition, or both. Neurotrophins (NTs) are a family of peptides that play a role in the regulation of nerve cells. Their effects on the lower urinary tract organs may provide a perspective to understand the development and diagnosis of UI. This study aims to investigate NT levels to understand how these molecules change in multiparous premenopausal women who suffer from stress-related UI. The study also evaluates diagnostic and distinguishing capabilities of NTs for these disorders.

Methods: In this cross-sectional case–control study, multiparous premenopausal women underwent a urodynamic examination, a stress cough test, and were evaluated with an International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF). Participants were divided into three groups: 29 healthy women in the control group and two patient groups consisting of 26 women diagnosed with stress urinary incontinence (SUI) and 33 women diagnosed with mixed urinary incontinence (MUI). Nerve growth factor (NGF), brain-derived neurotrophic factor, neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) levels in serum were measured by enzyme-linked immunosorbent assay. The body mass index (BMI) and ICIQ-SF scores of the patients were also calculated. The data obtained were compared between the groups. Receiver-operating characteristic analysis was performed to determine the role of NTs in diagnosing UI.

Results: The result showed that serum NGF and NT-3 levels were significantly low in both incontinence subtypes compared to the control group (p < 0.05). BMI scores and number of vaginal deliveries were higher in incontinence subtypes compared to the control group, and ICIQ-SF scores were higher in the MUI group.

Conclusion: The differences in serum NGF and NT-3 levels were observed in multiparous premenopausal patients with UI. There was a decrease in serum NGF levels in MUI patients and serum NT-3 levels in SUI patients. Although the changes in serum NGF and NT-3 levels were significant, their discriminatory potential was weak or moderate.
The effect of SLC5A5 gene expression in tumor tissues on refractoriness to radioactive iodine treatment of differentiated thyroid carcinomas
Authors: Erten Aslı , Sayiner Zeynel Abidin , Erkılıç Suna , OğFuzkan Balcı Sibel , Akarsu Ersin 
Published: February 2025

Background and objective: The majority of thyroid cancer patients have a good prognosis. Even in advanced disease, the radioactive iodine (RAI) response improves the prognosis. However, RAI refractoriness poses a significant challenge for these patients. The objective of the study was to assess the expression of SCL5A5 as a potential marker for predicting future resistance to radioiodine treatment.

Materials and methods: Radioactive iodine-refractory papillary thyroid carcinoma (RAIR-PTC) and iodine-sensitive papillary thyroid carcinoma (PTC) were included in the study. Demographic and clinicopathological data were retrospectively analyzed. RNA samples were converted to cDNA. Gene expression reactions were performed using synthesized solute carrier family 5 member 5 (SLC5A5) and glyceraldehyde-3-phosphate dehydrogenase (GADPH) primer samples.

Results: Of the patients, 51 (61.4%) had iodine-sensitive PTC and 32 (38.5%) were RAIR-PTC. Patients were followed up for 8 ± 6.4 years. The mean age at diagnosis was higher in the RAIR-PTC group (56.56 ± 15.22 years vs. 46.82 ± 12.43 years, p = 0.002). The PTC group had higher SLC5A5 gene expression than RAIR-PTC. In addition, no statistically significant correlation was observed between basal thyroglobulin levels and tumor standardized uptake value-maximum (SUV-max) on fluorodeoxyglucose positron emission tomography (p = 0.304).

Conclusion: SLC5A5 gene expression is reduced in radioactive iodine-refractory thyroid carcinoma. Furthermore, the decreased expression status of the SLC5A5 gene before preablative iodine treatment may serve as a predictive indicator of future resistance to RAI therapy.
Retinal Diseases Classification using Deep Learning
Authors:   ofessor, Dept of Computer Engineering, JSPM’s Jayawantrao Sawant College of Engineering Pune, Shivarkar1 Sayali 
Published: February 2025

Retinal diseases, encompassing a wide spectrum of ocular disorders, pose significant threats to vision and overall eye health. Early and accurate diagnosis is crucial for timely intervention and treatment planning. In recent years, the integration of deep learning techniques into medical imaging has revolutionized the field of ophthalmology. This study explores the application of deep learning algorithms for the classification of retinal diseases using high-resolution retinal images. This study presents a comprehensive and innovative framework for retinal disease classification using deep learning, addressing critical technical challenges and ethical considerations. The developed model represents a significant step towards enhancing the accuracy and efficiency of retinal disease diagnosis, ultimately improving patient outcomes and the quality of eye care..

Keywords : Retinal movement, disease discrimination, deep learning, CNN classifier.
Peramalan Inflasi Kota Pontianak dengan Metode Seasonal Autoregressive Integrated Moving Average
Authors: Aulia Alwa , Huda Nur'ainul Miftahul 
Published: February 2025

Inflasi merupakan alat pengukur stabilitas ekonomi yang selalu menarik untuk dibahas karena memiliki dampak yang signifikan pada pertumbuhan ekonomi, daya saing, neraca perdagangan eksternal, bunga kredit, dan pemerataan pendapatan. Inflasi merujuk pada meningkatnya harga barang dan jasa yang tidak pernah berhenti selama periode tertentu. Peningkatan harga ini dapat mengakibatkan penurunan nilai uang. Untuk menyelesaikan masalah ini, perlu dilakukan prediksi untuk menghitung nilai inflasi di masa depan. Penelitian ini menerapkan metode Seasonal Autoregressive Moving Average (SARIMA) untuk memprediksi nilai inflasi di Kota Pontianak dari Januari hingga Desember 2025. Data yang diolah pada penelitian ini diperoleh dari BPS Kota Pontianak. Model terbaik bergantung pada hasil uji akurasi dengan nilai MAPE. Berdasarkan hasil analisis yang dilakukan, model merupakan model terbaik untuk melakukan prediksi nilai inflasi di Kota Pontianak dengan nilai MAPE yaitu 2,02%.
Literasi pentingnya menjaga ekosistem pohon mangrove dan Kegiatan Donor Darah dalam Peningkatan Kesejahteraan Masyarakat Pesisir di Pantai Bagan Serdang Kecamatan Pantai Labu Kabupaten Serdang Bedagai
Authors: Silalahi Alistraja Dison , Pangeran Pangeran , Hutagaol Jarungjung , Amra Ricca Nophia , Tampubolon Khairuddin , Tulim Anto 
Published: February 2025

Hutan mangrove merupakan ekosistem pesisir yang vital dengan peran ekologis dan ekonomi yang krusial. Namun, keberadaan hutan mangrove di Indonesia saat ini terancam oleh berbagai faktor, seperti alih fungsi lahan, pencemaran, dan eksploitasi berlebihan. Menjaga kelestarian hutan mangrove menjadi sebuah keharusan untuk melindungi keseimbangan alam dan menjamin keberlanjutan manfaatnya bagi manusia. Literasi mengenai pentingnya menjaga ekosistem mangrove perlu ditingkatkan untuk mendorong partisipasi aktif masyarakat dalam upaya pelestarian. Menjaga kelestarian ekosistem mangrove merupakan tanggung jawab bersama. Upaya kolektif dari pemerintah, masyarakat, dan organisasi swadaya diperlukan untuk memastikan kelestarian hutan mangrove dan manfaatnya bagi generasi sekarang dan masa depan. Peningkatan literasi mengenai pentingnya menjaga ekosistem mangrove menjadi kunci utama untuk mendorong partisipasi aktif masyarakat dalam upaya pelestarian.Kata Kunci: Literasi; ekosistem; pohon mangrove; Kegiatan Donor Darah.
Tratamiento de los neurodatos en Chile: analisis de jurisprudencia de la Corte Suprema de Chile
Authors: Rodriguez Astudillo Nelson 
Published: February 2025

The Supreme Court of Chile ruled for the first time regarding the use and collection of information related to neurological activity, by virtue of the appeal to the sentence that had ruled against the Protection Appeal issued by the Illustrious Court of Appeals of Santiago, in Case N°. 49852-2022, filed by former senator Mr. Guido Girardi against the international company Emotiv Inc., marketer of the “Insight” product, a wireless device composed of a ribbon that is attached to the head as a kind of headset, with three-prong rubber sensors, which collect information about the electrical activity of the brain, obtaining data on gestures, movements, preferences, reaction times and cognitive activity of the user.
La Corte Suprema de Chile se pronunció por primera vez respecto al uso y la recopilación de información referida a la actividad neurológica, en virtud de la apelación a la sentencia que había fallado en contra del Recurso de Protección dictado por la Ilustre Corte de Apelaciones de Santiago, en Causa Rol49852-2022, deducido por el exsenador don Guido Girardi en contra de la empresa internacional Emotiv Inc., comercializadora del producto “Insight”, dispositivo inalámbrico compuesto por una cinta que se adosa a la cabeza como una especie de auricular, con sensores de goma de tres puntas, que recaban información sobre la actividad eléctrica del cerebro,obteniendo datos sobre gestos, movimientos, preferencias, tiempos de reacción y actividad cognitiva de quien lo usa.
ANÁLISIS DE LOS FACTORES DE DESARROLLO DEL TURISMO BÉLICO A TRAVÉS DE UN MODELO EXPLORATORIO
Authors: Blanco-Gregory Rocío , Peloche Fernández Eugenia Victoria 
Published: February 2025

War tourism is a form of tourism that has been practised mainly since the First World War, although its academic study is relatively recent. In the reviewed research, a lack of studies focused on the factors driving the development of war tourism has been identified, prompting the proposal of an explanatory model to analyse these factors. To this end, the Structural Equation Modeling (PLS-SEM) method was used to evaluate five constructs through various indicators, including tourist motivations, considered essential and fundamental according to the limited literature available. A questionnaire was administered to a sample of 150 residents from Extremadura and surrounding areas to gather data on the different indicators. The successful validation of the model's hypotheses regarding variable interactions implies its broader applicability in exploring other influential factors in war tourism's development.
El turismo bélico es una forma de turismo que se practica fundamentalmente, a partir de la I Guerra Mundial, aunque su estudio académico es relativamente reciente. En las investigaciones revisadas, se observa una carencia de estudios centrados en los factores que impulsan el desarrollo del turismo bélico, por lo que aquí se propone un modelo explicativo para analizarlos. Para ello, se empleó el Modelo de Ecuaciones Estructurales (PLS-SEM) para evaluar cinco constructos a través de distintos indicadores, entre los cuales se incluyeron las motivaciones de los turistas, consideradas esenciales y fundamentales según la escasa literatura disponible. Se aplicó un cuestionario a una muestra de 150 habitantes de Extremadura y sus alrededores para recolectar datos sobre los diferentes indicadores. Las hipótesis sobre las relaciones entre las variables fueron aceptadas, conviniendo que el modelo propuesto puede aplicarse a otros factores, verificando su trascendencia en el desarrollo del turismo bélico.
Tradisi Istighosah Sebagai Penolak Bala Perspektif Sosiologi Pengetahuan Karl Manheim (Studi Living Quran Bacaan Istighosah di PP. Al-Furqon Wedoroanom Driyorejo Gresik)
Authors: Nisa Anis Choirun , Rahmawati Kharolina 
Published: February 2025

Skripsi ini merupakan penelitian living Quran yang memaparkan tradisi istighosah sebagai media penolak bala di Pondok Pesantren yang merupakan pondok berbasis semi modern. Adapun dua hal yang menjadi tujuan dalam penelitian ini adalah : mengetahui bagaimana praktik istighosah di pondok pesantren Al-Furqon, serta mengetahui bagaimana resepi pengasuh, santri dan masyarakat terkait istighosah sebagai penolak bala. Penelitian ini adalah penelitian deskriptif kualitatif, dengan menggunakan teknik observasi, wawancara dan dokumentasi dalam proses pengumpulan data. Sumber data primernya adalah segala informasi yang diperoleh dari pengasuh pondok, santri dan masyarakat. Sedangkan data sekundernya adalah buku-buku, dokumentasi pondok dan lainnya yang berkaitan dengan tradisi pembacaan istighosah tersebut. Hasil dari penelitian ini menyimpulkan bahwa kegiatan istighosah di Pondok Pesantren Al-Furqon di lakukan dalam dua waktu. Pertama istighosah dilakukan setiap hari ba’da sholat subuh di ikuti oleh seluruh santri dan para asatidz pondok. Kedua istighosah dilakukan sepekan sekali pada hari jum’at sebelum kegiatan belajar mengajar yang di ikuti oleh seluruh tenaga pengajar, santri dan masyarakat sekitar pondok. Adapun resepsi masyarakat pada istighosah sebagai penolak bala dibahas menggunakan tiga dimensi makna dari teori sosiologi pengetahuan milik Karl Mannheim. Tiga dimensi makna ini yaitu : makna obyektif, makna ekspresif, makna dokumenter. Makna objektif terdapat pada bacaan istighosah yang mana terdiri dari do’a dan dzikir-dzikir khusus seperti surat Al-Fatihah, Asma’ul Husna, Tahmid, Tasbih, Takbir, Tahlil dan surat Yasin. Setiap bacaan memiliki keutamaan berbeda, sehingga jika dibaca secara bersamaan maka akan menimbulkan banyak pengaruh positif. Kemudian, makna ekspresif berupa ketenangan hati bagi orang yang melakukan istighosah secara istiqomah. Sedangkan makna dokumenter dari penelitian ini yaitu kegiatan istighosah merupakan kegiatan yang sudah umum di tengah-tengah masyarakat dan di beberapa pesantren khususnya.
Islamic Education Teachers' Strategies in Fostering the Morals of Vocational High School Students
Authors: Syafruddin  
Published: February 2025

The process of guidance and moral development for students is a momentum to overcome all kinds of student actions that lead to behavior that is not in accordance with norms, so that guidance and counseling provide solutions and alternatives for all kinds of problems faced by students. In order to develop their morals, Islamic Religious Education teachers need to use special strategies so that they are expected to have a positive impact on improving their religious beliefs and developing their morals. This research aims to: (1) examine in depth the strategies used by Islamic Religious Education (PAI) teachers in developing students' morals at SMK in Aceh, (2) analyzing the moral development patterns implemented, (3) identifying supporting factors and obstacles in the process of moral development. This research uses a descriptive qualitative approach, with data collection techniques through observation, interviews and documentation. The results of this research show that PAI teachers at SMK in Aceh use various strategies to develop students' morals, including example, habituation, advice, punishment and training. The moral development pattern implemented at SMK Aceh includes various routine activities such as reading prayers and the Koran before starting learning and special programs such as recitations and lectures once a week. Supporting factors in moral development at SMK in Aceh include commitment and good cooperation between teachers, parents and students, as well as a school environment that supports moral development through various positive activities. Apart from that, support from the school in providing programs that support moral development is also an important factor. Several inhibiting factors include the lack of supporting facilities and infrastructure such as special rooms for religious activities and the negative influence of the environment outside the school which can influence student behavior.
The Analysis Study of Relationship of Breast Arterial Calcifications on Mammography to Predict Elevated Risk of Coronary Artery Disease: A Comprehensive Systematic Review
Authors: Rendi Rafsanjani  , Bintara Ayu Putri  , Mutiara Nurul Mahabbah  
Published: February 2025

Background: Breast arterial calcifications (BAC) are medial arterial calcifications visualized as linear "tram-track" deposits in the breast vasculature on mammograms. Women with BAC have been found to have higher coronary artery calcium (CAC) scores and increased prevalence of cardiovascular risk factors such as diabetes, hypertension, and chronic kidney disease. This systematic review aims to comprehensively evaluate the current evidence on the relationship between BAC and CAD risk. Methods: The study followed PRISMA 2020 guidelines, reviewing English-language publications from 2015 to 2025. Editorials, duplicate reviews from the same journal, and papers lacking a DOI were excluded. The literature search was conducted using PubMed, SagePub, SpringerLink, and Google Scholar. Result: A total of 2,172 articles were initially identified through online databases (PubMed, SagePub, SpringerLink, and Google Scholar). After three rounds of screening, eight relevant studies were selected for full-text analysis. Conclusion: The relationship between BAC and CAD is well-supported by retrospective studies, demonstrating significant associations with coronary calcification, cardiovascular risk factors, and disease severity. While BAC may not serve as a standalone diagnostic tool, its potential as an adjunct marker for CAD risk stratification is promising.
Análise comparativa de implantes faciais mais utilizados para rejuvenescimento facial
Authors: Rocha Jorge Henrique Fernandes da , Xavier Melissa Gomes Vieira 
Published: February 2025

Atualmente, sabe-se que o rejuvenescimento facial é constituído por características tridimensionais, envolvendo a perda da textura cutânea, da gordura facial e ósseas devido à remodelação e redistribuição dos elementos. O presente trabalho almeja, através de uma revisão integrativa da literatura, compreender o melhor método definitivo para o rejuvenescimento facial, comparando as complicações, durabilidade e sucessos alcançados. Ao fim do trabalho, temos a confirmação de que o uso do polietileno poroso apresenta uma maior vantagem de adaptação e, consequentemente, uma menor taxa de intercorrências, sendo a principal delas as infecções. Conclui-se assim que o polietileno poroso proporciona um resultado bom resultado quanto ao rejuvenescimento, com bom contorno facial, menor taxas de intercorrências e de de abordagens, além de uma maior segurança ao logo prazo.
A375 melanoma-derived lactate controls A375 melanoma phenotypes by inducing macrophage M2 polarization via TCA cycle and TGF-β signaling
Authors: Wang Qifei , Shi Yurui , Qin Zelian , Xu Mengli , Wang Jingyi , Lu Yuhao , Zhao Zhenmin , Bi Hongsen 
Published: February 2025

Introduction
Macrophage phenotypes have been linked to progression and prognosis of cutaneous melanoma. However, the association between Warburg effect in A375 melanoma and macrophages polarization, as well as the underlying mechanisms, remains less well documented.

Objective
The present study aimed to investigate the effect of lactate derived from A375 melanoma on macrophage polarization, melanoma phenotype responses and the underlying mechanisms.

Methods
Flow cytometry was performed to evaluate the expression of M1 and M2 markers, cell cycle and apoptosis. Levels of transforming growth factor β (TGF-β) and tumor necrosis factor α (TNF-α) were determined with enzyme-linked immunosorbent assay (ELISA) kit. Proliferation and invasion were assessed by CCK8 and transwell assays, respectively. The extracellular acidification rate (ECAR) and oxygen consumption rate (OCR) were analyzed using an XF96 extracellular flux analyzer. Protein expressions were determined by Western blotting.

Results
Our results revealed that melanoma A375 conditioned medium (A375-CM) induced peripheral blood mononuclear cells (PBMCs) to polarize toward anti-inflammatory M2 macrophages. M2 markers CD206 and ARG1 expression increased, as did TGF-β secretion. Conversely, M1 marker CD68 expression decreased. Furthermore, hypoxia promoted macrophage M2 polarization induced by A375-CM. Elevated lactate level in PIG1-conditioned medium (PIG1-CM) induced M2 polarization, whereas the lactate transport inhibitor AZD3965 suppressed this effect in PBMCs cultured with A375-CM. Additionally, lactate derived from melanoma regulated M1/M2 polarization by the tricarboxylic acid (TCA) cycle instead of glycolysis. Significantly, polarized macrophages altered melanoma phenotypes including proliferation, clone formation, cell cycle, apoptosis, migration and invasion via TCA cycle and TGF-β.

Conclusion
Our data collectively demonstrate that lactate derived from melanoma facilitates polarization of M2 macrophages, which subsequently leads to modifications in melanoma phenotypes via TCA cycle and TGF-β signaling.