bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of calcium gluconate administration during cardiopulmonary bypass on hemodynamic variables in infants undergoing open-heart surgery
Authors: Faritous Seyedeh Zahra , Zaree Saeed Rajabzade , Morshedizad Zohreh , Jalali Amir Hossein , Mahani Soha Mehrabi , Gholampour Maziar 
Published: April 2022

Abstract
Background
The incidence of complications after heart surgery is a critical factor in disability, deaths, lengthening hospital stays, and increasing treatment costs. The metabolic balance of certain hormones and electrolytes is necessary for proper cardiac function. In children, various biochemical conditions may cause calcium depletion during heart surgery. The purpose of this study was to determine the effect of calcium gluconate administration during cardiopulmonary bypass on hemodynamic variables and clinical outcomes in infants undergoing open-heart surgery. This study was conducted at Rajaie Cardiovascular Medical and Research Center in 2021 using a controlled randomized clinical trial. A total of 60 patients with open-heart surgery weighing up to 10 kg were included in the study. The first group received an intravenous injection of calcium gluconate 20 min after opening the aortic clamp, and the second group was monitored as a control group. Data collection tools included checklists containing demographics, surgical information, and intensive care unit measures.

Results
The Chi-square test or Fisher's exact test showed that the frequency distribution of gender, blood group, Rhesus factor (RH), and clinical diagnosis in the two groups of intervention and control was not statistically significant (p < 0.05). The mean and standard deviation of Ejection Fraction (EF) changes (before and after) were 13.27 ± 9.16 in the intervention group and 8.31 ± 9.80 in the control group (p = 0.065). The results of two-way repeated measures ANOVA showed that mean systolic blood pressure (p = 0.030), mean diastolic blood pressure (p = 0.021), mean heart rate (p = 0.025), mean arterial pressure (p = 0.020), mean pH (p < 0.001), and mean hemoglobin (p = 0.018) in the intervention, and control groups were statistically significant.

Conclusions
In the present study, unlike systolic pressure, mean diastolic blood pressure decreased, and mean arterial pressure increased significantly. As a result, the slope of changes during the study period was different in the intervention and control groups.
Chronic lung disease in paediatric patients: Does magnetic resonance imaging has a role?
Authors: Ibrahim Rania S. M. , Hafez Mona A. F. 
Published: April 2022

Abstract
Background
Pediatric chronic lung disease (CLD) refers to a range of distinct clinical and pathological disorders that affect children. High-resolution CT (HRCT) is critical for detecting and characterizing parenchymal abnormalities as well as determining their nature and distribution. Although magnetic resonance imaging (MRI) shows promising results, however, due to its poor spatial resolution and signal-to-noise ratio, imaging of the lung parenchyma remains a challenge. As a result, in addition to the initial CT, a follow-up MRI is required. The goal of this paper is to highlight the main imaging features of children with CLD and to evaluate the efficacy of MRI lungs in the diagnosis and monitoring of pediatric CLD.

Results
There was a strong positive correlation between CT and MRI, with a significant P-value. Findings of HRCT and MRI showed a qualitative agreement of 78% complete agreement. MRI helped primary diagnosis in 54% of cases compared to CT in 91% of cases.

Conclusion
MRI lungs are an equivalent technique to HRCT in assessing pediatric CLD; using the modified Helbich–Bhalla score, a strong correlation is obvious between both in the overall assessment. MRI is beneficial for case surveillance rather than primary diagnosis.
Blood oxygenation response to aerobic exercise combined with breathing exercises in pregnant women: a randomized controlled trial
Authors: Elsisi Hany F. E. M. , Aneis Yasser M. , El Refaye Ghada E. , Ghareeb Hassan O. 
Published: April 2022

AbstractBackgroundThere are many physiological changes occur during pregnancy that affect oxygenation of the pregnant women. It was considered that aerobic and breathing exercises are safe for the mother and the fetus especially moderate intensity exercise during pregnancy.ObjectiveThis study was designed to investigate the blood oxygenation response to aerobic exercise combined with breathing exercises in pregnant women.MethodologyForty pregnant women were selected from obstetrics and gynecology outpatient clinic at Kasr El Einy Hospital, Egypt, confidentiality was assured. They were ranged from 25 to 30 years old, with body mass index (BMI) less than 30 kg/m2and at the beginning of 3rdtrimester, this study was conducted from September 2019 to April 2020. They were assigned into two groups: group A performed aerobic exercise in a form of walking for 20 min. On the treadmill at 60–75% of the maximum heart rate (MHR) of each woman, three times per week in addition to deep breathing exercises in form of diaphragmatic and lateral costal breathing; group B who performed deep breathing exercises only in form of diaphragmatic and lateral costal breathing. The program continued for three months, three times per week. The oxygen saturation (SaO2) was measured twice time, firstly, at the beginning of 3rdtrimester of pregnancy then after three months of treatment program.ResultsThe results of this study revealed a statistically significant difference in the oxygen saturation in group A than in group B.ConclusionIt could be concluded that there was significant statistical effect of aerobic exercise combined with breathing exercises on blood oxygenation in pregnant women. It improved the oxygen saturation in pregnant women.
Microvascular Decompression for Hypoglossal Nerve Palsy Associated With Vertebral Artery: Case Report and Review of Literature
Authors: Shafizadeh Milad , Maroufi Seyed Farzad , Ahmadi Maryam , Khoshnevisan Alireza 
Published: April 2022

BACKGROUND AND IMPORTANCE:
Hypoglossal nerve palsy is an infrequent condition that could be rarely caused by compression from nearing vasculature. Hypoglossal nerve palsy associated with vertebral artery (VA) is rarely reported. There are less than 15 cases of such conditions in the literature.

CLINICAL PRESENTATION:
We present a 17-year-old boy suffering from dysarthria, chewing disability, a tingling sensation, and deviation of the tongue to the right from 6 months ago. After a thorough examination, MRI was performed with clinical suspicion of hypoglossal nerve palsy, and the result showed an ectatic VA pressing against the right hypoglossal nerve. He underwent microvascular decompression surgery. On follow-up visits, he showed gradual improvement of symptoms.

CONCLUSION:
In cases of cranial nerve palsies, compression by adjacent vasculature should be considered as a differential diagnosis and microvascular compression should be considered as a safe definitive treatment.
Diversity and antimicrobial activity of marine nudibranch associated bacteria against tropical human skin pathogens
Authors: Sabdono Agus , Radjasa Ocky , Trianto Agus , Korshunova Tatiana , Martynov Alexander , Sibero Mada 
Published: April 2022

Background: Skin disease is the fourth most common disease among all diseases. The number of cases of skin diseases continues to increase, and people commonly use antibiotics to treat these diseases. Nevertheless, overuse of antibiotics can increase the resistance of these pathogens. Hence, the study of novel antibiotic compounds against multi-drug resistant (MDR) skin pathogens is urgently needed. Methods: This study describes the antimicrobial diversity of bacteria associated with three species of marine nudibranchs (Jorunna funebris, Gymnodoris rubropapulosa, and Glossodoris atromarginata) sampled from Jepara coastal waters, the North Java Sea in August 2020. A total of 115 bacterial strains were selected for their prospective antipathogenic compounds against the pathogens Cutibacterium acnes, Staphylococcus aureus, Candida albicans, and Malassezia furfur. Results: A total of 24 bacterial isolates (20.87%) exhibited antimicrobial activity against the pathogens that were selected and molecularly identified. Analyses of the gene of 16S rRNA discovered that these 24 isolates were associated with 11 genera of the phyla Firmicutes, Proteobacteria, and Actinobacteria, including Bacillus as the dominant genus, followed by Streptomyces, Gordonia, Salinicola, Thalassospira, Halomonas, Dietzia, Brevibacterium, Paracoccus, Pseudovibrio, Pseudoalteromonas, and Pseudomonas. None of the 24 antimicrobial bacterial strains possessed type-1 polyketide synthases (PKS-I). One strain possessed type II polyketide synthases (PKS-II), and five strains possessed non-ribosomal peptide synthetase (NRPS) genes. The amounts of bacterial genus and strains in the three nudibranchs differed significantly, as did the proportions of antimicrobial strains in each nudibranch species. The antibacterial strains isolated from G. atromarginata were the highest number (62.5%), followed by J. funebris (20.8%) and G. rubropapulosa (16.7%). Conclusions: These results demonstrate that nudibranch species harbor prominent and varied communities of bacteria and reveal that many nudibranch-associated bacteria have the potential for the advancement of broad-spectrum antibiotics.
Intestinal inflammation and increased intestinal permeability in Plasmodium chabaudi AS infected mice
Authors: Mooney Jason P , DonVito Sophia M , Lim Rivka , Keith Marianne , Pickles Lia , Maguire Eleanor A , Wagner-Gamble Tara , Oldfield Thomas , Bermejo Pariente Ana , Ehimiyien Ajoke M , Philbey Adrian A , Bottomley Christian , Riley Eleanor M , Thompson Joanne 
Published: April 2022

Background: Gastrointestinal symptoms are commonly associated with acute Plasmodium spp infection. Malaria-associated enteritis may provide an opportunity for enteric pathogens to breach the intestinal mucosa, resulting in life-threatening systemic infections. Methods: To investigate whether intestinal pathology also occurs during infection with a murine model of mild and resolving malaria, C57BL/6J mice were inoculated with recently mosquito-transmitted Plasmodium chabaudi AS. At schizogony, intestinal tissues were collected for quantification and localisation of immune mediators and malaria parasites, by PCR and immunohistochemistry. Inflammatory proteins were measured in plasma and faeces and intestinal permeability was assessed by FITC-dextran translocation after oral administration. Results: Parasitaemia peaked at approx. 1.5% at day 9 and resolved by day 14, with mice experiencing significant and transient anaemia but no weight loss. Plasma IFN-γ, TNF-α and IL10 were significantly elevated during peak infection and quantitative RT-PCR of the intestine revealed a significant increase in transcripts for ifng and cxcl10. Histological analysis revealed parasites within blood vessels of both the submucosa and intestinal villi and evidence of mild crypt hyperplasia. In faeces, concentrations of the inflammatory marker lactoferrin were significantly raised on days 9 and 11 and FITC-dextran was detected in plasma on days 7 to 14. At day 11, plasma FITC-dextran concentration was significantly positively correlated with peripheral parasitemia and faecal lactoferrin concentration. Conclusions: In summary, using a relevant, attenuated model of malaria, we have found that acute infection is associated with intestinal inflammation and increased intestinal permeability. This model can now be used to explore the mechanisms of parasite-induced intestinal inflammation and to assess the impact of increased intestinal permeability on translocation of enteropathogens.
Long distance high resolution FMCW laser ranging with phase noise compensation and 2D signal processing
Authors: Ke Jia-Yi , Song Zi-Qi , Wang Pei-Si , Cui Zhong-Ming , Mo Di , Lin Miao , Wang Ran , Wu Jin 
Published: April 2022

A long distance high resolution frequency-modulated continuous wave (FMCW) laser rangefinder with phase noise compensation and two-dimensional (2D) data processing skills is developed. Range-finding ladar consists of a continuously chirped laser source, an auxiliary reference interferometer, and a monostatic optical transceiver for target illumination and return photon collection. To extend the range unambiguity and lower the electronic processing bandwidth, a two-step laser frequency chirping scheme is adopted, where a long pulse width, small frequency bandwidth laser chirping signal are used in step 1 for coarse distance estimation, and a short pulse width and large frequency bandwidth laser chirping signal are applied afterwards for step 2 high resolution distance realization. An auxiliary reference interferometer is to record the phase noise originated from the laser source to compensate for phase errors induced in the target return photons. The 2D data processing skill helps to coherently sum up all the phase noise removed echo photons to achieve high resolution range peak extraction with high detection sensitivity. Experimental demonstration shows that the proposed FMCW ladar at 1550 nm wavelength with a laser chirping bandwidth of 10 GHz and electronic processing bandwidth of 200 MHz can measure a corner cube test target in an outdoor atmospheric environment, and the measurement results are 12013.905 m with a 2.4 cm range resolution under strong return photon levels and 12013.920 m with a 2.5 cm range resolution under weak return photon levels.
Coherent angular signal amplification using an optical cavity
Authors: Shimoda Tomofumi , Miyazaki Yuki , Enomoto Yutaro , Nagano Koji , Ando Masaki 
Published: April 2022

Precision angular sensing is an essential technology in physical experiments. Unlike
length sensing with a laser beam, it has been thought that sensitivity
to the angular motion cannot be enhanced with the help of an optical
cavity. A method of angular signal amplification using an optical
cavity, called the cavity-amplified angular sensor (CAAS), is
proposed. By adjusting or compensating for the Gouy phase of the
cavity, the electric field of the laser generated in proportion to the
target rotation is coherently stacked in the proposed method. The
advantage of this method over other angular sensors is its high
sensitivity with the small sensing spot size. Three possible optical
configurations are considered, of which two experimentally available
ones are investigated. The angular signal amplification is
demonstrated for both of them. Based on the theoretical calculation
for a realistic model, the fundamental angular sensing noise level is
expected to be as low as

10

−
15

r
a
d

/

H

z

1

/

2

, with a 1 mm laser beam size and
10 mW laser power.
3D single-pixel imaging at the near-infrared wave band
Authors: Zhao Haixiao , Li Peiming , Ma Yanyang , Jiang Shan , Sun Baoqing 
Published: April 2022

Focal plane detector array technology in the infrared wave band is expensive or underdeveloped, and the detection efficiency is low, while single-pixel imaging (SPI) offers better performance, such as ultrafast time response and high quantum efficiency in wide wave bands. Therefore, SPI technology can be used for infrared imaging. In this work, a near-infrared raster scan SPI system is proposed. By means of a grating to modulate height information of objects, we can further achieve three-dimensional imaging in the framework of Fourier transform profilometry. The proposed approach is demonstrated with experiments at the wavelength of 1064 nm.
Schlüsselfaktoren erfolgreicher CIOs
Authors: Hillebrand Patrick , Westner Markus , Matschi Markus 
Published: April 2022

ZusammenfassungDie vorliegende Studie untersucht Schlüsselfaktoren erfolgreicher CIOs in deutschen Großunternehmen. Mit einer mittleren Verweildauer (Median) von 4,0 Jahren weisen deutsche CIOs, die mit 43 % noch überwiegend an den CFO berichten, im Vergleich zu anderen C‑Level-Positionen eine deutlich kürzere Verweildauer im Amt auf. Die Ergebnisse aus 60 Interviews mit erfolgreichen deutschsprachigen CIOs, die primär über eine überdurchschnittlich lange Verweildauer verfügen, lassen verschiedene Schlüsselfaktoren für den Erfolg erkennen: Grundvoraussetzung ist stets die Gewährleistung eines sicheren und effizienten IT-Betriebs. Über effektive und innovative Change-Projekte machen die interviewten CIOs den IT-Mehrwert transparent und agieren als Brückenbauer zwischen IT und Fachbereichen. Dadurch wirken sie positiv auf die Firmenkultur ein und etablieren die IT nachhaltig in den Fachbereichen als Erfolgsfaktor. Erfolgreiche CIOs selbst sind keine „Techies“, sondern zeichnen sich durch hohe Führungskompetenz und ein hohes Geschäftsverständnis, gepaart mit visionärem Denken aus. Dadurch gelingt es ihnen, die IT zukunftsorientiert auszurichten und Anforderungen und Potenziale für und aus den Fachbereichen frühzeitig zu antizipieren. Die zukünftige Entwicklung der CIO-Organisation und der Paradigmen in der IT wird durch die Studienteilnehmer hingegen teilweise kontrovers diskutiert – so gibt es beispielsweise bei der Beurteilung der Sinnhaftigkeit und Relevanz der CDO-Position noch kein einheitliches Meinungsbild.
Systematic identification and characterization of long noncoding RNAs (lncRNAs) during Aedes albopictus development
Authors: Liu Wenjuan , Cheng Peng , Zhang Kexin , Gong Maoqing , Zhang Zhong , Zhang Ruiling 
Published: April 2022

BackgroundAedes albopictusoriginated in the tropical forests of Southeast Asia and can currently be found on all continents. As one of the main arboviral vectors, the control ofAe.albopictusrequires novel strategies, informed by a deep knowledge of its biology. Little is known regarding mosquito long noncoding RNAs (lncRNAs), which are transcripts longer than 200 nucleotides that lack protein-coding potential and have roles in developmental regulation.ResultsBased on RNA-seq data from five developmental time points, eggs, early larvae, late larvae, pupae, and adults (female and male) ofAe.albopictus, 21,414 lncRNAs were characterized in this study. Differential expression analysis revealed that lncRNAs exhibited developmental stage specificity. The expression of most lncRNAs was upregulated at the onset of metamorphosis developmental stages. More differentially expressed lncRNAs were observed between eggs and early larvae. Weighted gene co-expression network analysis (WGCNA) further confirmed that the expression patterns of lncRNAs were obviously correlated with specific developmental time points. Functional annotation using co-expression analysis revealed that lncRNAs may be involved in the regulation of metamorphic developmental transitions ofAe.albopictus. The hub lncRNAs and hub gene clusters were identified for each module that were highly associated with specific developmental time points.ConclusionsThe results of this study will facilitate future researches to elucidate the regulatory mechanisms of lncRNAs in the development ofAe.albopictusand utilize lncRNAs to assist with mosquito control.
Development of Duchenne Video Assessment scorecards to evaluate ease of movement among those with Duchenne muscular dystrophy
Authors: Contesse Marielle G. , Lowes Linda P. , White Michelle K. , Dalle Pazze Laura , McSherry Christine , Alfano Lindsay N. , Iammarino Megan , Reash Natalie , Bonarrigo Kelly , Kiefer Michael , Laubscher Katie , McIntyre Melissa , Mockler Shelley , Nelson Leslie , Vogel Leslie , Leffler Mindy G. 
Published: April 2022

BackgroundPatients with Duchenne muscular dystrophy (DMD) adopt compensatory movement patterns as muscles weaken. The Duchenne Video Assessment (DVA) measures patient ease of movement through identification of compensatory movement patterns. The DVA directs caregivers to video record patients performing specific movement tasks at home using a secure mobile application, and DVA-certified physical therapists (PTs) score the videos using scorecards with prespecified compensatory movement criteria. The goal of this study was to develop and refine the DVA scorecards.MethodsTo develop the initial scorecards, 4 PTs collaboratively created compensatory movement lists for each task, and researchers structured the lists into scorecards. A 2-round modified Delphi process was used to gather expert opinion on the understandability, comprehensiveness, and clinical meaningfulness of the compensatory movements on the scorecards. Eight PTs who had evaluated ≥50 patients with DMD and participated in ≥10 DMD clinical trials were recruited for the panel. In Round 1, panelists evaluated compensatory movement criteria understandability via questionnaire and tested the scorecards. In Round 2, panelists participated in an in-person meeting to discuss areas of disagreement from Round 1 and reach consensus (≥75% agreement) on all revisions to the scorecards.ResultsDuring the Round 1 revisions to the scorecards, there were 67 changes (44%) to the wording of 153 original compensatory movement criteria and 3 criteria were removed. During the Round 2 revisions to the scorecards, there were 47 changes (31%) to the wording of 150 compensatory movement criteria, 20 criteria were added, and 30 criteria were removed. The panel reached 100% agreement on all changes made to scorecards during Round 2.ConclusionPTs with extensive experience evaluating patients with DMD confirmed that the compensatory movement criteria included in the DVA scorecards were understandable, comprehensive, and clinically meaningful.
Size and Concentration of Extracellular Vesicles in Pancreatic Juice From Patients With Pancreatic Ductal Adenocarcinoma
Authors: Nesteruk Kateryna , Levink Iris J.M. , Dits Natasja F.J. , Cahen Djuna L. , Peppelenbosch Maikel P. , Bruno Marco J. , Fuhler Gwenny M. 
Published: April 2022

INTRODUCTION:
Extracellular vesicles (EVs) and their cargo may provide promising biomarkers for the early detection of pancreatic ductal adenocarcinoma (PDAC). Although blood-borne EVs are most frequently studied as cancer biomarkers, pancreatic juice (PJ) may represent a better biomarker source because it is in close contact with the ductal cells from which PDAC arises. It is, as yet, unknown whether PDAC results in a distinct type or increased number of particles in PJ and whether this has diagnostic value.

METHODS:
Secretin-stimulated PJ was collected from the duodenum of 54 cases and 117 nonmalignant controls under surveillance for PDAC. Serum was available for a subset of these individuals. The vesicular composition of these biofluids was analyzed with nanoparticle tracking analysis.

RESULTS:
The concentration of EVs did not differ between controls and PDAC cases. However, a higher number of large vesicles were found in PJ (but not serum) for patients with PDAC compared with controls.

DISCUSSION:
The composition of isolated EVs from PJ, but not serum, is altered in patients with PDAC. This suggests that PJ may carry disease-specific markers not present in serum and provides a valuable biomarker source for PDAC diagnosis. The nature of the larger particles in EV isolates from PJ of PDAC cases requires further investigation.
Clinical case of indolent primary medullary cancer
Authors: Miroshnikov S. V. , Demin D. B. , Belyaeva A. I. 
Published: April 2022

Medullary thyroid cancer (MRSH) has a high malignant potential in the vast majority of cases, but in some patients with MRSH is characterized by a sluggish, non-aggressive course, when patients with the presence of proven medullary carcinoma or distant metastases and / or relapse, can live without progression for a sufficiently long time. Such a course of a malignant tumor is called indolent. The article presents a clinical case of diagnosis and treatment of indolent primary MRSH in a patient with a duration of the disease of 11 years. Shows some features of the dynamics of the level of basal calcitonin and cancer-embryonic antigen (CEA), ultrasound characteristics and data of fine-needle puncture biopsy of the tumor. The phenomenon of indolent course of MRSH characterized, as a rule, by a high malignant potential, is probably due to the biological characteristics of the tumor and requires further research.