bluuebunny/crossref_metadata_2025_split huggingface dataset:
The social factors and functions of media use
Authors: Grady Sara M , Tamborini Ron , Eden Allison , Van Der Heide Brandon 
Published: September 2022

AbstractA heuristic model aims to organize and synthesize the substantial body of work examining the social influences that shape media selection, experiences, and effects. The Social Influences and Media Use (SIMU) model describes three broad social forces (users’ internal social needs, their social environment, and the social affordances of media) and their recursive association with media use. This article (a) brings together diverse subdisciplines interested in the social factors and functions of media use, (b) discusses the micro–macro nature of social phenomena and its potential role in future inquires, and (c) illustrates how the model might foster new developments by applying it in a specific area of study. The model may help us identify cohesive patterns (and points of divergence or uniqueness) among existing findings as well as inform future work examining these relationships across a variety of social contexts and media channels.
Cefadroxil Use for Musculoskeletal Infections in an Academic Pediatric Hospital
Authors: Weslander Erin , Thomas Holly , Jeune Ralph , Green Michael , Williams John V 
Published: September 2022

Abstract
Forty-nine of 52 (94.2%) children with musculoskeletal infection (MSKI) were successfully treated with cefadroxil dosed at 30 mg/kg/day over a 10-year time period. Two failures were associated with poor medication adherence. Our study suggests that treatment of MSKI with cefadroxil offers acceptable outcomes. Confirmation through clinical trials is appropriate.
Lessons Learned From the U.S. Military Experience With Hantavirus During the Korean War
Authors: Rouabhia Ramsey , Dinh Dung T , Kua Siang C , Washington Michael A 
Published: September 2022

ABSTRACT

Introduction
The Korean War (1950-1953) consisted of two phases. The first was a rapid mobile phase, and the second was a slow and stationary phase. During the stationary phase, approximately 3,000 UN troops became infected with a then unknown agent. The resulting illness began with flu-like symptoms and often progressed to a severe hemorrhagic fever leading to kidney failure and death. However, the cause was not to be identified until well over 20 years following the conclusion of the war when Dr. Ho Wang Lee succeeded in isolating Hantavirus from field rodents. The U.S. Military experience with Hantavirus during the Korean War is a case study of the potential impact of war-related environmental change on disease transmission. The lessons learned from this experience should inform future military medical planning and serve as a reminder of the impact that an unknown agent can have on military operations.

Materials and Methods
A literature review of all available records with respect to the U.S. Military experience with Hantavirus was conducted. PubMed was the primary search engine used for this review. However, primary literature and historical accounts were also evaluated. All records were examined for environmental, epidemiological, and public health data regarding hemorrhagic fever outbreaks among U.S. forces during the Korean War. The quantitative and qualitative data from these sources were analyzed and evaluated within the context of military medical planning and force health protection to derive lessons learned that should be applied to the management and mitigation of viral disease in future wars.

Results
Widespread deforestation resulting from war-related efforts most likely played a significant role in the outbreaks of Hantavirus among UN forces during the war. A lack of cultural literacy and an overreliance on erroneous assumptions most likely delayed the identification of the true causative agent. It is conceivable that these delays led to an increased casualty rate and that they had a negative impact on military operations during the war.

Conclusions
A basic understanding of the ecological mechanisms that maintain species diversity in the local environment coupled with an appreciation for the impact of environmental change on this diversity is of paramount importance for the prevention and mitigation of viral disease outbreaks in the deployed setting. Military medical planners should become familiar with the medical literature of the region in which they will be operating as this literature often describes the agents that will most likely be encountered by U.S. forces.
A Search for Unbound Stellar Companions to Pulsar J1124−5916
Authors: Kochanek C S 
Published: September 2022

ABSTRACT
We searched for and found no higher mass (${\gtrsim}3{\rm M}_\odot$) unbound binary stellar companions to the progenitor of pulsar J1124−5916. There are lower mass candidates, but they all have high probabilities of being false positives. There are no candidates for it now being a fully unbound triple system. Even if one of the lower mass candidates is an unbound companion, it seems unlikely that it could have contributed to stripping the progenitor prior to the supernova. The stars are too low mass to be significant mass gainers, and they are too slowly moving to be the survivors of a compact, post-common envelope binary. The addition of one more system slightly improves the statistical constraints on the binary and triple status of supernova progenitors just before and after death.
Local Volume dwarf KK242: radial velocity, SF region and metallicity
Authors: Pustilnik S A , Tepliakova A L , Perepelitsyna Y A , Kniazev A Y , Makarova L N , Burenkov A N , Kotov S S , Malygin E A 
Published: September 2022

Abstract
KK242 is a LV dwarf of transition type residing in the void environment. Koda et al. present clear indications on its connection with Scd galaxy NGC6503. This implies the distance to KK242 of ∼6.3 Mpc and its MB=–10.5 mag. Its radial velocity, known from the Effelsberg radio telescope H i observations, reveals, however, the difference with that of NGC6503, ΔV∼400 km s−1. If real, this fact implies the substantial constraints on its origin. To clear-up the issue of KK242 radial velocity, we obtained with the SAO 6-m telescope spectra of its faint star-forming (SF) complex. Hα and Hβ emission is detected in two adjacent compact regions, the southern and northern, separated by ∼2 arcsec (∼60 pc). Their mean radial velocity is Vhel=–66 km s−1, ∼100 km s−1 lower than that of NGC6503. We use the HST Legacy Archive images and photometry of individual stars from the Extragalactic Distance Database, available for KK242, to identify in the SF complex the exciting hot stars, the probable BHeB and RHeB stars and a supernova remnant. We address, based on the possible range of its gas metallicity, the probable evolutionary paths of KK242. Using package Cloudy and parameters of the exciting B0V stars, we conclude that the observed flux ratio of the [S ii] doublet to Hα is consistent with the value of 12+log (O/H) ∼7.35 ±0.18 dex, expected for a stripped void dIrr galaxy.
Genealogy, Evaluation, and Engineering
Authors: Queloz Matthieu 
Published: September 2022

AbstractAgainst those who identify genealogy with reductive genealogical debunking or deny it evaluative significance, I argue, first, that while genealogies tend to trace the higher to the lower, they need not reduce the higher to the lower, but can elucidate their relation and help us think more realistically about both relata; second, that if we conceive of genealogy in terms of a triadic model including the addressee, it becomes intelligible how tracing the higher to the lower can facilitate an evaluation of the higher, and how, where the lower is some important practical need rather than some sinister motive, the genealogy can even be vindicatory; and third, that vindicatory genealogies can offer positive guidance on how to engineer better concepts.
IEAtlas: an atlas of HLA-presented immune epitopes derived from non-coding regions
Authors: Cai Yangyang , Lv Dezhong , Li Donghao , Yin Jiaqi , Ma Yingying , Luo Ya , Fu Limei , Ding Na , Li Yongsheng , Pan Zhenwei , Li Xia , Xu Juan 
Published: September 2022

Abstract
Cancer-related epitopes can engage the immune system against tumor cells, thus exploring epitopes derived from non-coding regions is emerging as a fascinating field in cancer immunotherapies. Here, we described a database, IEAtlas (http://bio-bigdata.hrbmu.edu.cn/IEAtlas), which aims to provide and visualize the comprehensive atlas of human leukocyte antigen (HLA)-presented immunogenic epitopes derived from non-coding regions. IEAtlas reanalyzed publicly available mass spectrometry-based HLA immunopeptidome datasets against our integrated benchmarked non-canonical open reading frame information. The current IEAtlas identified 245 870 non-canonical epitopes binding to HLA-I/II allotypes across 15 cancer types and 30 non-cancerous tissues, greatly expanding the cancer immunopeptidome. IEAtlas further evaluates the immunogenicity via several commonly used immunogenic features, including HLA binding affinity, stability and T-cell receptor recognition. In addition, IEAtlas provides the biochemical properties of epitopes as well as the clinical relevance of corresponding genes across major cancer types and normal tissues. Several flexible tools were also developed to aid retrieval and to analyze the epitopes derived from non-coding regions. Overall, IEAtlas will serve as a valuable resource for investigating the immunogenic capacity of non-canonical epitopes and the potential as therapeutic cancer vaccines.
Occupational asthma in teachers
Authors: Burge S , Moore V , Burge C , Robertson A , Huntley C , Walters G 
Published: September 2022

Abstract

Background
Work-related asthma symptoms are common in teachers and teaching assistants, there are few studies evaluating their causes.

Aims
To identify causes of occupational asthma in teachers and teaching assistants referred to the Birmingham Occupational Lung Disease clinic 2000–20 using evaluation of serial Peak Expiratory Flow (PEF) records.

Methods
Teachers and teaching assistants with possible occupational asthma were asked to record PEF 2-hourly at home and work for 4 weeks. Their records were evaluated with the Oasys programme. Those with a positive score for any of the three scores (area between curves (ABC), timepoint and Oasys score from discriminant analysis) were included. Repeat records were made as indicated to help identify the cause and the effects of remedial actions.

Results
Thirty-eight teachers or teaching assistants met the inclusion criteria with all three Oasys scores positive in 24, 2/3 scores in nine and 1/3 in five. The building was the likely cause in 17 (in new builds particularly acrylates from carpet adhesives and in old buildings mould and construction dust), bystander exposure to agents in the schools in 12 (cleaning agents, acrylates from photocopiers and chloramines from indoor pools) and materials used in the classroom in 9 (most commonly MDF in design and technology classes). We illustrate how the PEF records helped identify the cause.

Conclusions
Oasys analysis of PEF records is a useful method of evaluating occupational asthma in teachers and identified difficult to confirm causes where successful remediation or redeployment was achieved.
The antioxidant, tert-butylhydroquinone: a new cause of asthma
Authors: Sherson D L , Jacobsen I B , Thomsen G F 
Published: September 2022

SummaryThe antioxidant, tert-butylhydroquinone (TBHQ), a common additive in food and cosmetics can cause allergic contact dermatitis. A 49-year-old non-atopic male factory worker developed asthma in connection with cleaning mixing drums containing TBHQ. Due to the suspicion that TBHQ might be the cause of asthma, a specific inhalation challenge was carried out. Lactose was used as a control agent. The following day he developed asthma symptoms with a 41% drop in FEV1 after 30-min exposure to small amounts of TBHQ and water. Methacholine reactivity increased 5-fold after TBHQ exposure compared to pre-exposure reactivity. This suggests that TBHQ may be the cause of asthma in this case. Due to this case respirators were introduced in the factory to reduce TBHQ exposure. TBHQ has not previously been shown to cause asthma.
EGFR Mutations and PD-L1 Expression in Early-Stage Non-Small Cell Lung Cancer: A Real-World Data From a Single Center in Brazil
Authors: Alves Pinto Icaro , de Oliveira Cavagna Rodrigo , Virginio da Silva Aline Larissa , Dias Josiane Mourão , Santana Iara Vidigal , Souza Laísa Caroline , Ferreira da Silva Flávio Augusto , Biazotto Fernandes Maria Fernanda , Junqueira Pinto Gustavo Dix , Negreiros Izabella Santos , Santiago Gonçalves Maria Fernanda , de Paula Flávia Escremim , Berardinelli Gustavo Nóriz , Casagrande Giovanna Maria Stanfoca , Oliveira da Silva Marcela , Albino da Silva Eduardo Caetano , de Oliveira Marco Antonio , Jacinto Alexandre Arthur , Duval da Silva Vinicius , Reis Rui Manuel , De Marchi Pedro , Leal Letícia Ferro 
Published: September 2022

Abstract

Background
Targeted and immunotherapies are currently moving toward early-stage settings for patients with non-small cell lung cancer (NSCLC). Predictive biomarkers data are scarce in this scenario. We aimed to describe the frequency of EGFR mutations and PD-L1 expression levels in early-stage non-squamous patients with NSCLC from a large, single Brazilian oncology center.

Methods
We retrospectively evaluated patients with NSCLC diagnosed at an early-stage (IB to IIIA-AJCC seventh edition) at Barretos Cancer Hospital (n = 302). EGFR mutational status was assessed in FFPE tumor tissues using distinct methodologies (NGS, Cobas, or Sanger sequencing). PD-L1 expression was evaluated by immunohistochemistry (clone 22C3) and reported as Tumor Proportion Score (TPS), categorized as &lt;1%, 1-49%, and ≥50%. We evaluated the association between EGFR mutational status and PD-L1 expression with sociodemographic and clinicopathological parameters by Fisher’s test, qui-square test, and logistic regression. Survival analysis was assessed by the Kaplan-Meier method and Cox regression model.

Results
EGFR mutations were detected in 17.3% (n = 48) of cases and were associated with female sex, never smokers, and longer overall and event-free survival. PD-L1 positivity was observed in 36.7% (n = 69) of cases [TPS 1-49% n = 44(23.4%); TPS ≥50% n = 25(13.3%)]. PD-L1 positivity was associated with smoking, weight loss, and higher disease stages (IIB/IIIA).

Conclusion
The frequencies of EGFR mutations and PD-L1 positivity were described for early-stage non-squamous patients with NSCLC. These results will be essential for guiding treatment strategies with the recent approvals of osimertinib and immunotherapy in the adjuvant setting.
Reductions in All-Cause Mortality Associated with the Use of Methylnaltrexone for Opioid-Induced Bowel Disorders: A Pooled Analysis
Authors: Webster Lynn R , Brenner Darren , Israel Robert J , Stambler Nancy , Slatkin Neal E 
Published: September 2022

AbstractObjectivePreclinical and clinical studies suggest that activation of the µ-opioid receptor may reduce overall survival and increase the risk for all-cause mortality in patients with cancer and noncancer pain. Methylnaltrexone, a selective, peripherally acting µ-opioid receptor antagonist, has demonstrated efficacy for the treatment of opioid-induced constipation. This retrospective analysis of 12 randomized, double-blind, placebo-controlled studies of methylnaltrexone evaluated the treatment of opioid-induced bowel disorders in patients with advanced illness or noncancer pain.MethodsThe risk of all-cause mortality within 30 days after the last dose of study medication during the double-blind phase was compared between methylnaltrexone and placebo groups. The data were further stratified by cancer vs noncancer, age, gender, and acute vs chronic diagnoses.ResultsPooled data included 2,526 methylnaltrexone-treated patients of which 33 died, and 1,192 placebo-treated patients of which 35 died. The mortality rate was 17.8 deaths/100 person-years of exposure in the methylnaltrexone group and 49.5 deaths/100 person-years of exposure for the placebo group. The all-cause mortality risk was significantly lower among patients receiving methylnaltrexone compared with placebo (hazard ratio: 0.399, 95% confidence interval: 0.25, 0.64; P = .0002), corresponding to a 60% risk reduction. Significant risk reductions were observed for those receiving methylnaltrexone who had cancer or chronic diagnoses. Methylnaltrexone-treated patients had a significantly reduced mortality risk compared with placebo regardless of age or gender.ConclusionsMethylnaltrexone reduced all-cause mortality vs placebo treatment across multiple trials, suggesting methylnaltrexone may confer survival benefits in patients with opioid-induced bowel disorders taking opioids for cancer-related or chronic noncancer pain.
Analgesic Electrical Stimulation Combined with Wrist-Ankle Acupuncture Reduces the Cortical Response to Pain in Patients with Myofasciitis: A Randomized Clinical Trial
Authors: Du Jiahao , Shi Ping , Liu Junwen , Yu Hongliu , Fang Fanfu 
Published: September 2022

AbstractObjectiveTranscutaneous electrical nerve stimulation (TENS) based on wrist-ankle acupuncture has been shown to relieve pain levels in patients with myofascial pain syndrome (MPS). However, its efficacy is highly subjective. The purpose of this study was to evaluate the feasibility and effectiveness of TENS based on wrist-ankle acupuncture for pain management in patients with MPS from the perspective of cerebral cortex hemodynamics.Design, setting, participants and interventionsWe designed a double-blind, randomized, controlled clinical trial. Thirty-one male patients with MPS were randomly assigned to two parallel groups. The experimental group (n = 16) received TENS based on wrist-ankle acupuncture for analgesic treatment, while the control group (n = 15) did not. The pain was induced by mechanically pressurized at acupoint Jianjing. The multichannel functional near-infrared spectroscopy (fNIRS) equipment was utilized for measuring oxyhemoglobin (HbO) levels in the cerebral cortex during the tasks.ResultsAfter the intervention, visual analog scale (VAS), the activation degree and activation area of pain perception cortices were significantly reduced in the experimental group compared to the baseline values (P &lt; .05). Particularly, Frontopolar Area (FPA), and Dorsolateral Prefrontal Cortex (DLPFC) are highly involved in the pain process and pain modulation.ConclusionCompared to no intervention, TENS based on wrist-ankle acupuncture can be effective in relieving pain in patients with MPS in terms of cerebral cortical hemodynamics. However, further studies are necessary to quantify the analgesic effect in terms of cerebral hemodynamics and brain activation.
Contribution of the Wolffian duct mesenchyme to the formation of the female reproductive tract
Authors: Zhao Fei , Grimm Sara A , Jia Shua , Yao Humphrey Hung-Chang 
Published: September 2022

AbstractThe female reproductive tract develops from its embryonic precursor, the Müllerian duct. In close proximity to the Müllerian duct lies the precursor for the male reproductive tract, the Wolffian duct, which is eliminated in the female embryo during sexual differentiation. We discovered that a component of the Wolffian duct, its mesenchyme, is not eliminated after sexual differentiation. Instead, the Wolffian duct mesenchyme underwent changes in transcriptome and chromatin accessibility from male tract to female tract identity, and became a unique mesenchymal population in the female reproductive tract with localization and transcriptome distinct from the mesenchyme derived from the Müllerian duct. Partial ablation of the Wolffian duct mesenchyme stunted the growth of the fetal female reproductive tract in ex vivo organ culture. These findings reveal a new fetal origin of mesenchymal tissues for female reproductive tract formation and reshape our understanding of sexual differentiation of reproductive tracts.
Work participation is unaffected in Belgian spondyloarthritis patients: data from the BelGian Inflammatory Arthritis and SpoNdylitis cohorT
Authors: De Craemer Ann-Sophie , Deroo Liselotte , Renson Thomas , Desimpele Ine , Delmez Lauren , Decuman Saskia , Janssens Xavier , Boonen Annelies , Elewaut Dirk , Carron Philippe , Van den Bosch Filip 
Published: September 2022

AbstractObjectivesThis study aimed to (i) investigate actual work participation in Belgian spondyloarthritis (SpA) patients compared with the general population, and (ii) identify determinants of work-related outcomes.Material and methodsAdult SpA patients from the Ghent University Hospital based Be-GIANT cohort (fulfilling ASAS classification criteria) were cross-sectionally questioned on their socio-economic status and completed a Work Productivity and Activity Impairment questionnaire (May 2018 to May 2019). Results were compared with national and regional data on the general population using indirect standardization. Associations between clinical and job characteristics and work-related outcomes were analysed with logistic regression (having a paid job) and negative binomial hurdle models (sick leave and presenteeism, i.e. restrictions while at work).ResultsA total of 215/262 (82%) patients of working age (&lt;65 y/o) had a paid job, corresponding to an age- and sex-adjusted employment ratio of 1.00 (95% CI 0.88, 1.14). Patients worked 39.6h (10.5h)/week, and 49% (95% CI 42, 56%) reported sick leave in the previous year, similar to the general population (39.7h/week, 42%). In total, 56% reported presenteeism of median (IQR) 10% (0–20%). In multivariate analysis, functional impairment (BASFI) and health-related quality of life (HRQoL, EuroQoL-VAS) were associated with each work-related outcome, while contextual factors (education, physically demanding job) were positively associated with, respectively, having a paid job and presenteeism. Clinical characteristics showed no independent association with any of these outcomes.ConclusionsEvidence from this academic cohort study does not support a work participation gap between SpA patients and the general population, but confirms the role of physical function, overall HRQoL, and education or job type as risk factors for adverse work outcomes.
Evaluation of Patient Transmission Factor Following the Administration of 177Lu-DOTATATE
Authors: Recca Kimyli , Muneeb Aeman , Helstern Christopher , Lemieux Bryan , Das Satya , Jessop Aaron 
Published: September 2022

Abstract

177Lu-DOTATATE is a radionuclide therapy that is FDA approved for the treatment of somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors. Treatment facilities are required to determine the maximum radiation dose from such subjects to the maximally exposed member of the public, ensuring that the total effective dose equivalent (TEDE) does not exceed regulatory limits. If the calculated TEDE meets the regulatory limits, the patient is eligible for release and provided instructions with radiation precautions. This study aims to determine a mean transmission factor to the patient to improve accuracy and individualize the estimation of the TEDE.