bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of 2 medium cutoff dialyzers versus on‐line hemodiafiltration regarding depurative ability and albumin loss: An uncontrolled clinical research
Authors: Martínez‐Miguel Patricia , Gimena Muñoz Rocío , Barrionuevo González Marta , López‐Ongil Susana , Moro María Ángeles , Lizasoain Ignacio , Rodríguez‐Puyol Diego , García Segura Juan Manuel 
Published: November 2022

AbstractBackgroundHemodialysis (HD) techniques that best remove molecules in the middle to high molecular weight range are on‐line hemodiafiltration (OL‐HDF) and HD with medium cut‐off (MCO) membranes. The aim of this study was to compare efficacy and safety of OL‐HDF with FxCordiax HDF 800™, with HD with 2 MCO dialyzers: Theranova 500® and the new Elisio 21HX™ dialyzer.MethodsFourteen patients following treatment with OL‐HDF using FxCordiax HDF 800™ were randomized to receive a consecutive 1‐week HD treatment with Theranova 500® and Elisio 21HX™.The reduction rate (RR) of differently sized molecules was compared, as well as the variation rate in molecules smaller than 1000, detected by nuclear magnetic resonance based chemometrics (metabolomics). Albumin loss in dialysate was quantified.ResultsLower RRs were found for molecules around 20 000 with Elisio 21HX™ compared to OL‐ HDF (RR prolactin 58.5% versus 66.7%, p = 0.034; RR Kappa light chain 63.1% versus 71.8%, p = 0.010). Albumin loss per session was higher with Theranova 500® than with OL‐HDF and with Elisio 21HX™ (2249.9 ± 714.1 mg, 815.2 ± 474.0 mg, 442.9 ± 135.9 mg, p < 0.001, respectively). Metabolomic studies suggested, by semi‐quantitative analysis, a greater depurative capacity of OL‐HDF, followed by Elisio 21HX™, and then Theranova 500®.ConclusionsIn this study, HD with Theranova 500® has proven to be very similar in efficacy to OL‐HDF, although with a significantly higher albumin loss. HD with Elisio 21HX™ resulted in lower removal of molecules around 20 000 compared to OL‐HDF, with no significant difference compared to Theranova 500®, and with less albumin loss than Theranova 500®.
Quinoline‐based heterocyclic hydrazones: Design, synthesis, anti‐plasmodial assessment, and mechanistic insights
Authors: Sharma Bharvi , Chowdhary Shefali , Legac Jenny , Rosenthal Philip J. , Kumar Vipan 
Published: November 2022

AbstractA library of quinoline‐based hydrazones bearing 1H‐1,2,3‐triazole core was designed, synthesized, and evaluated for their antiplasmodial activity against the drug‐resistant Plasmodium falciparum W2 strain. The inclusion of pyrazine‐2‐carboxylic acid with a flexible propyl spacer afforded the most active scaffold with an IC50 value of 0.26 μM. Mechanistically, the compound inhibited heme to hemozoin formation, as demonstrated by UV–vis and mass spectral studies.
The relationship of body image and weight: A cross‐sectional observational study of a Dutch female sample
Authors: Makarawung Dennis J. S. , Boers Mijke J. , van den Brink Femke , Monpellier Valerie M. , Woertman Liesbeth , Mink van der Molen Aebele B. , Geenen Rinie 
Published: November 2022

SummaryBody image concerns may play a role in weight changing behaviour. The objective of this study was to assess body image in different weight groups. Participants reported satisfaction with (AE) and investment in (AO) appearance, and the discrepancy between current and ideal body size (BS). These scores were compared between weight groups based on body‐mass index (BMI) using analysis of variance. One‐sample t‐tests and Cohen's d effect sizes examined the magnitude of differences within each weight group relative to neutral midpoints of the scales; cluster analysis identified body image profiles. A total of 27 896 women were included in this study. AE scores were highest for people with underweight and normal weight, AO scores were highest for the underweight group and lowest in class III obesity, and BS scores were largest in the obese groups (all p < .001) Cluster analysis identified eight body image profiles. In people with obesity, the most prevalent profiles included a preference for a smaller body and low satisfaction with appearance, but differed in investment in appearance (low vs. high). Most people with underweight were allocated to profiles showing high investment in their appearance, preference of a larger body, but differences in satisfaction with appearance (neutral vs. high). While people with a higher BMI have on average more body image concerns, different body image profiles exist in all weight groups. Future research should examine whether and which individuals in terms of body image profile may benefit more from weight interventions.
Lack of SIRP‐alpha reduces lung cancer growth in mice by promoting anti‐tumour ability of macrophages and neutrophils
Authors: Pan Linyue , Wang Bin , Chen Mengjie , Ma Yuan , Cui Bo , Chen Zhihong , Song Yuanlin , Hu Lijuan , Jiang Zhilong 
Published: November 2022

AbstractObjectivesSignal regulatory protein‐alpha (SIRPα) is a transmembrane glycoprotein specifically expressed on myeloid cells. Blockade of SIRPα/CD47 interaction is effective in combinational therapy of some cancers. This study aimed to explore into the role and underlying molecular mechanisms of SIRPα in lung cancer growth.Materials and MethodsA mouse model with lung cancer in wild‐type (WT) and SIRPα‐knockout mouse (KO) mice was established by subcutaneous injection of Lewis murine lung cancer cells (LLC). Circulating monocytes and neutrophils were depleted in mice by intraperitoneal administration of clodronate liposomes and anti‐Ly6G antibody, respectively. Phenotypes and phagocytosis of macrophages and neutrophils were analysed by flow cytometry. Transwell assay was used to analyse LLC cells migration and invasion.ResultsLack of SIRPα inhibited LLC cells growth in KO mice, associated with reduced infiltrating PD‐1+CD8+ T cells and production of IL‐6 from infiltrating macrophages and neutrophils in tumour tissues. Depletion of circulating monocytes and neutrophils reduced LLC cells growth in WT mice, which was abolished in KO mice. Studies in vitro showed that lack of SIRPα increased M1/M2 ratio, and reduced LLC cell migration and invasion via attenuated IL‐6 secretion. Lack of SIRPα expression in neutrophils effectively increased the cytotoxic activity to LLC cells in vitro.ConclusionsLack of SIRPα suppressed lung cancer cell growth in mice, dependent on circulating macrophages and neutrophils, in association with improved phagocytosis and reduced IL‐6 expression.
Changes in the cell composition of the hemolymph in the snail Planorbarius corneus after infection with the trematode Plagiorchis sp.
Authors: Serebryakova Maria K. , Tokmakova Arina S. , Prokhorova Elena E. , Ataev Gennady L. 
Published: November 2022

AbstractWe found two functional populations of hemocytes in the hemolymph of the pulmonate snail Planorbarius corneus: hyalinocytes and granulocytes. The hyalinocytes were much more numerous than granulocytes. Each population was subdivided into subpopulations based on morphological and functional characteristics. The hyalinocyte population was represented by two subpopulations differing in size, granularity, and ability to form pseudopodia. In snails infected with the trematodes Plagiorchis sp., the cellular composition of the hemolymph changes, with hemocytes being mostly represented by granulocytes. This phenomenon is associated with the fact that granulocytes form a hemocytic paletot on the surface of sporocysts of Plagiorchis sp. It is suggested that pulmonate molluscs have one lineage of hemolymph cells. Hematopoietic stem cells can divide, ensuring multiplication of prohemocytes. The latter differentiate into hyalinocytes, which, in turn, differentiate into granulocytes.
Polymorphisms in some proinflammatory genes (TNFα and β, IL‐1β, IL‐6, ADAM17) in severe chronic venous disease
Authors: Slonková Veronika , Vašků Anna , Vašků Vladimír 
Published: November 2022

AbstractBackgroundChronic venous disease (CVD) is a common disorder of lower extremities.ObjectivesThe study was scheduled to investigate the relationship between polymorphisms in major proinflammatory genes TNF α (−238 A/G; −308 A/G), TNF β (NcoI), IL‐1β (+3953 T/C); IL‐6 (−174 G/C; −596 G/C) and ADAM17 (3′TACE) and CVD risk. Genotype–phenotype study was calculated to test possible association between examined genotypes and phenotypes of CVD.MethodsFinally, 150 CVD patients and 227 control subjects were enrolled to the study.Genotypes in proinflammatory gene polymorphisms were identified from isolated DNA by PCR method and restriction analysis.ResultsSignificant differences in genotype distribution/allelic frequencies in TNF β gene, IL‐1 β gene and in ADAM17 gene polymorphisms were found between CVD women and control ones. In the genotype–phenotype study, identified genotypes were associated with arterial hypertension (ADAM17, IL‐6‐men), ischaemic heart disease (TNF α and β genes), diabetes mellitus (ADAM17‐women, TNF β‐men), age of CVD onset (TNF α and IL‐6), ulceration (ADAM17), duration of ulceration (ADAM17), ulceration recurrence (ADAM17‐women), home care necessity (TNF α), varices surgery (TNF α), erysipelas development (ADAM17‐men) and tumour development (TNF α).ConclusionStudying of these polymorphisms associations can help us better identify patients at higher risk of developing severe CVD.
Return to community living and mortality after moving to a long‐term care facility: A nationally representative cohort study
Authors: Lam Kenneth , Cenzer Irena , Covinsky Kenneth E. 
Published: November 2022

AbstractBackgroundRecent long‐term care facility (LTCF) policy has focused on transitioning nursing home (NH) residents back to community settings, yet we lack recent descriptions of this phenomenon and how it compares in assisted living (AL).MethodsUsing the National Health and Aging Trends Study, we studied adults over age 65 who had moved from community living into an LTCF between 2011 and 2018. Persons or their proxies reported residence in annual interviews. NH was defined by facility staff. ALs were multi‐unit buildings helping with activities of daily living. We excluded temporary short‐stay NH patients and independent AL residents. Our primary outcome was cumulative incidence of return to community living, with death as co‐primary outcome and modeled as a competing risk, stratified by NH versus AL entry. We identified covariates (age, gender, race/ethnicity, dementia, activity limitations, and prior living arrangement) associated with return to community living through bivariate and multivariable logistic regression.ResultsAmong 739 participants, weighted mean age was 84 years (SD 7.5), 66% were women, 13% were non‐White, 57% had dementia, and 41% entered NH. At 1, 2, and 4 years, the cumulative incidence of return to community living was 2.9% (95% CIs: 1.9%–4.3%), 6.4% (4.7%–8.4%), and 7.4% (5.5%–9.8%); the cumulative incidence of death was 28% (95% CIs: 24%–31%), 44% (40%–48%) and 66% (61%–70%). Outcomes were similar in persons entering NH versus AL. Older persons (aOR 0.88, 95% CI 0.83–0.94), those with dementia (aOR 0.33, 95% CI 0.12–0.88), and those previously living alone (aOR 0.39, 95% CI 0.17–0.89) were less likely to return.ConclusionsFew returned to community living after entering either NH or AL. Mortality was similar. Results highlight limits in transitioning persons out of LTCFs and the need to observe AL use to ensure policies do not merely displace persons between institutional care sectors.
Surgical management of dystocia in a colobus monkey (Colobus guereza)
Authors: Hinkle Daria , Rooney Tess , Klocke Emily , Eshar David 
Published: November 2022

AbstractA 14‐year‐old female black and white colobus monkey (Colobus guereza) presented in labor with fetal arms visible protruding from the vulva. Manual manipulation for assisted delivery of the fetus was unsuccessful. Radiographs identified a large fetal skull and hysterotomy was required with ovariohysterectomy elected to follow. The fetus was confirmed to be deceased during hysterotomy, but the dam recovered from the procedure uneventfully. The detailed description of the anesthesia and surgical procedure in this case may aid other clinicians when presented with similar dystocia cases in this species.
Mothers and public health nurses' experiences of sleep problems in children aged 6 months to 3 years: A qualitative study
Authors: Pettersen Sandtrø Hege , Glavin Kari , Størksen Hege Therese , Smogli Holter Marianne Therese , Drozd Filip 
Published: November 2022

AbstractAim and ObjectiveThe aim of this study was to explore mothers' and public health nurses' (PHN) experiences with sleep problems in children aged 6 months to 3 years in Norway.BackgroundSleep problems in children are common, affecting their health and development, and their mothers' well‐being. It is also the primary reason parents seek help in well‐child clinics (WCC). However, there is limited knowledge regarding the experiences of these mothers and the public health nurses who consult them.DesignQualitative design.MethodsFour semi‐structured focus group interviews were conducted: two with mothers (n = 14) who had children with sleep problems and two with public health nurses (n = 14) from well‐child clinics. The Framework Method was used for analysing the interviews of mothers. Data from public health nurses were charted onto the analytical framework of maternal data to understand how or whether public health nurses addressed the issues raised by mothers. The study is reported according to the COREQ checklist.ResultThe analysis resulted in two main themes: ‘therapeutic alliance’ (categories ‘alliance ruptures’ and ‘demanding negotiation process’) and ‘reorganisation of identity’ (categories ‘unfulfilled expectations’ and ‘internal tension conflicts’).ConclusionYoung children's sleep problems present challenges to new mothers due to failed expectations, negatively affecting their feelings as mothers and towards their children, and consequently the reorganising of maternal identity. Most mothers experienced unsatisfactory therapeutic alliances while seeking help from public health nurses because advice was considered overly general, contradictory and unsafe for their children. Public health nurses were mostly aware of the parental consequences of children's sleep problems, but many appeared unable to help because of limited time and knowledge.Relevance to Clinical PracticePublic health nurses need to establish a therapeutic alliance and provide evidence‐based knowledge and guidance on sleep problems while also considering women's reorganisation of identity when becoming mothers.Clinical Trial RegistrationOpen Science Framework: osf‐registrations‐6ag38‐v1 (https://archive.org/details/osf‐registrations‐6ag38‐v1).
“Welcome to OBGYN World!” A novel recruitment event for medical students organized by the Japan Society of Obstetrics and Gynecology
Authors: Miyake Ryuta , Komatsu Hiroaki , Ihira Kei , Hasegawa Akihiro , Maeda Yuto , Takemori Satoshi , Noguchi Masashi , Dofutsu Mihoko , Onodera Yohei , Shinagawa Manaka , Suemitsu Tokumasa , Sugita Yosuke , Higuchi Yayoi , Izaki Nanae , Kodera Chisato , Nagase Yoshikazu , Odawara Kei , Ogura Junpei , Osaku Daiken , Ohsuga Takuma , Enomoto Naosuke , Kanai Takahiro , Mishima Sakurako , Morita Keiko , Otsuka Satoyo , Suzuki Kensuke , Miura Kiyonori , Yoshida Yoshio 
Published: November 2022

Abstract“Welcome to OBGYN World!” A novel recruitment event for medical students organized by the Japan Society of Obstetrics and Gynecology. Since 2012, the number of doctors in Japan who specialize in obstetrics and gynecology has shown a decreasing trend. To increase the number of doctors majoring in obstetrics and gynecology, the Japanese Trainees in Obstetrics and Gynecology subcommittee developed a new recruitment event called Welcome to OBGYN World! (WOW!); the aim of this event was to focus on lower grades of medical students. The present report describes the content of WOW! and the results of a post‐event questionnaire administered to participating students and tutors. WOW! was held online in order to avoid the risk of Coronavirus Disease 2019 infection for participants. Sixty of the 82 medical schools nationwide (73.2%) participated in this event. Overall, there were 285 participating students, ranging from first to fourth grade in medical school, and 106 tutors were involved to teach material at the event. In the post‐event questionnaire survey, 97.6% (248/254) and 100% of the participants stated they now had a high degree of interest in obstetrics and gynecology and found the specialty attractive, respectively. Furthermore, 93.6% (90/94) of the tutors stated that WOW! had helped recruitment activities in their universities. Based on this outcome, members of the Japanese Trainees of Obstetrics and Gynecology subcommittee will now try to increase the number of doctors specializing in obstetrics and gynecology by holding WOW! annually.
Novel Three‐Holed Titanium Plate Fixation during Open Door Laminoplasty for Cervical Spondylotic Myelopathy: Comparison with Conventional Titanium Plate
Authors: Liu Fa‐jing , Liu Yan‐cheng , Hu Yong‐cheng , Ding Xiao‐kun , Miao Jun 
Published: November 2022

ObjectiveFor reconstructing the posterior cervical muscular–ligament complex, attachment points and various modified techniques were designed and applied in clinical practice. This study investigated the clinical and radiographic outcomes of open door laminoplasty with modified centerpiece mini‐plate fixation and extensor attachment point reconstruction in the treatment of cervical spondylotic myelopathy (CSM).MethodsSixty‐nine patients with CSM who underwent C3–C7 open door laminoplasty at our hospital from January 2016 to May 2018 were divided into two groups: 37 and 32 patients underwent laminoplasty with modified and conventional centerpiece titanium plate fixation (MPF and CPF groups), respectively. Changes in cervical spinal angle (CSA), cervical range of motion (ROM), posterior cervical muscle atrophy, neurological function (Japanese Orthopaedic Association [JOA] score), Neck Disability Index (NDI), and axial symptom severity were compared between the two groups.ResultsThere were no significant differences in operative duration (136.7 ± 23.9 vs 128.3 ± 21.5 min, t = 1.525, p > 0.05), volume of intraoperative blood loss (275.9 ± 33.1 vs 268.2 ± 31.6 ml, t = 0.984, p > 0.05), lamina open angle (41.2° ± 4.5° vs 39.4° ± 4.1°, t = 1.726, p > 0.05), and spinal cord drift distance (2.4 ± 0.3 vs 2.3 ± 0.4 mm, t = 1.184, p > 0.05) between the two groups. After surgery, JOA score significantly increased (p < 0.05), and neurological recovery rates were similar (62.7% vs 63.4%, t = 0.208, p > 0.05). The NDI score was significantly decreased in both the groups (p < 0.05); however, the MPF group recovered to a greater degree than the CPF group (8.3 ± 1.2 vs 9.8 ± 1.4) (t = 4.793, p < 0.05). There was no significant change in cervical ROM postoperatively compared with preoperatively in either group (p > 0.05). CSA decreased from 21.7° ± 2.8° to 18.3° ± 2.1°, and posterior cervical muscle cross‐sectional area decreased from 35.2 ± 4.9 cm2 to 31.0 ± 4.1 cm2 in the CPF group (p < 0.05), but no significant change was observed in the MPF group (20.6° ± 2.5° to 20.4° ± 2.6°and 35.9 ± 5.1 to 34.1 ± 4.6 cm2, respectively) (p > 0.05). Postoperative axial symptom severity was significantly worse in the CPF group than in the MPF group (Z = −2.357, p < 0.05).ConclusionsAs an improvement to the conventional titanium plate, the modified centerpiece titanium plate effectively provides an attachment point for the posterior muscle–ligament complex, reducing posterior cervical muscle atrophy and improving neck function, without inflicting additional surgical trauma.
Buccal transposition flap for closure of maxillary lip defects in 5 dogs
Authors: Hildebrandt Isabella M. , Skinner Owen T. , Souza Carlos H. de M. , Karnia James J. , Reeves Lauren A. , Mickelson Megan A. 
Published: November 2022

AbstractObjectiveTo describe the technique and outcomes of the closure of maxillary lip defects using a buccal transposition flap and to identify potential routes of vascular supply to the flap.AnimalsFive dogs treated clinically and 1 cadaveric dog head.Study designShort case series and cadaveric study.MethodsA left maxillary labial defect and a buccal transposition flap were created on a cadaver head. Iodinated contrast was injected into the left common carotid artery and computed tomography was performed to assess the vascular supply. Medical records were reviewed for all dogs that underwent tumor excision with maxillary lip resection, reconstructed with a buccal transposition flap.ResultsThe buccal transposition flap was perfused by branches of the angularis oris artery and superior labial artery. Five dogs were included in this study. All flaps survived. Three dogs developed postoperative complications, including oronasal fistula (n = 2) and partial flap dehiscence (n = 1). The cosmetic and functional outcomes were considered satisfactory in all cases.ConclusionBuccal transposition flaps for the closure of large maxillary lip defects provided adequate functional and cosmetic outcomes. The buccal transposition flap had vascular contributions from the angularis oris artery and the superior labial artery.
Efficacy of an Audio-Based Biofeedback Intervention to Modify Running Gait in Female Runners
Authors: Augustine Jacqueline A. , Rothstein Sarah , True Larissa , Dames Kevin D. 
Published: November 2022

Context: A variety of gait retraining interventions are available to modify running mechanics associated with musculoskeletal injuries. These often require specialized equipment and/or personnel to prompt the runner toward specific strategies. Objective: To determine whether instructing female recreational runners to “run quietly” could decrease impact force characteristics. Design: Cohort. Setting: Research laboratory. Participants: Fifteen healthy female recreational runners (24 [7] y) volunteered. Interventions: Baseline testing occurred on day 1 (baseline), a posttraining assessment occurred on day 2 (training), and a final assessment occurred 1 week after training on day 3 (follow-up). A smartphone decibel measuring app was used to provide biofeedback on the decibel level of foot strike on day 2 (training). Main Outcomes: Peak vertical force, impact transient, peak and average vertical loading rate, ground contact time, and running economy were collected on each day and compared via repeated-measures analyses of variance. Results: Vertical ground reaction force was lower at follow-up (2.30 bodyweights [BW]) versus baseline (2.39 BW, P = .023) and training (2.34 BW, P = .047). Maximal loading rate decreased from baseline (69.70 BW·s−1) to training (62.24 BW·s−1, P = .021) and follow-up (60.35 BW·s−1, P = .031). There was no change in running economy. Conclusions: Our findings demonstrate that simple instructions to “run quietly” can yield immediate and sustained reductions in impact force profiles, which do not influence running economy.