bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal vascular status and BMI-associated phenotyping is instrumental for predictive, preventive and personalised approach in healthy pregnancy
Authors: Evsevieva Maria , Sergeeva Oksana , Mazurakova Alena , Koklesova Lenka , Prokhorenko-Kolomoytseva Irina , Shchetinin Evgenij , Birkenbihl Colin , Costigliola Vincenzo , Kubatka Peter , Golubnitschaja Olga 
Published: July 2022

Abstract
Cardiovascular disease remains the leading cause of disease burden globally with far-reaching consequences including enormous socio-economic burden to healthcare and society at large. Cardiovascular health is decisive for reproductive function, healthy pregnancy and post-partum. During pregnancy, maternal cardio-vascular system is exposed to highly increased haemodynamic stress that significantly impacts health status of the mother and offspring. Resulting from sub-optimal maternal health conditions overlooked in pre-pregnancy time, progressive abnormalities can be expected during pregnancy and post-partum. Contextually, there are two main concepts to follow in the framework of 3P medicine, namely to develop 1. advanced screening of sub-optimal health in young populations to predict and prevent individual health risks prior to planned pregnancies2. in-depth companion diagnostics during pregnancy to predict and prevent long-lasting post-partum health risks of the mother and offspring. Data collected in the current study demonstrate group-specific complications in the mother and offspring and clinical relevance of BMI-related phenotyping in pre-pregnant mothers. Diagnostic approach proposed in this study revealed great clinical utility demonstrating important synergies between cardiovascular maladaptation and connective tissue dysfunction. Co-diagnosed pre-pregnancy low BMI of the mother, connective tissue dysfunction, increased stiffness of peripheral vessels and decreased blood pressure is considered a highly specific maternal phenotype useful for innovative screening programmes in young populations to predict and prevent severe risks to health of the mother and offspring. This crucial discovery brings together systemic effects characteristic, for example, for individuals with Flammer syndrome predisposed to the phenotype specific primary vascular dysregulation, pregnancy-associated risks, normal tension glaucoma, ischemic stroke at young age, impaired wound healing and associated disorders. Proposed maternal phenotyping is instrumental to predict individual maternal health risks associated with pregnancy and to protect both the mother and offspring against potential complications. Corresponding innovation applied to screening programmes focused on sub-optimal health in young populations and utilising here described phenotypes is pivotal for advanced health policy.
Intraoperative Tilted Pseudo Dropped Intraocular Lens.
Authors: Elkadim Mohamed 
Published: July 2022

Abstract
Pseudo intraoperative dropped intraocular lens (IOL) is a surgical situation that the surgeon finds the IOL luster so deep as if being in the vitreous, seeks touching the surface of the IOL, however, it's so far away. This situation can occur in cases of moderate myopia with narrow pupil and lax zonules with deeply seated posterior capsule particularly if the trailing haptic of the IOL is falsely implanted in the sulcus.
Application of the Enhanced Recovery After Surgery Protocol in Early Intensive Rehabilitation After Laminoplasty: A Mixed Methods Research
Authors: Zhang Zhiliang , Chu Hongling , Liu Xiaoxie , Zhou Mouwang , Zhou Feifei 
Published: July 2022

Abstract
Background: Perioperative rehabilitation treatment has not been popularized in China, and the team treatment approach still needs to be promoted. In this study, we incorporate early postoperative intensive rehabilitation into the enhanced recovery after surgery (ERAS) protocol of laminoplasty. Objective: To explore the treatment outcome of postoperative intensive rehabilitation after laminoplasty under the ERAS protocol, by using mixed methods research. Methods: The intensive rehabilitation group received hospitalized rehabilitation treatment for 1 week while the orthopedic treatment group exercised themselves at home after surgery. Forty-one patients were included in the intensive rehabilitation group and 33 patients in the orthopedic treatment group. The VAS, mJOA, and NDI score of the two groups were compared. Subsequently, through the qualitative research method of a semi-structured interview, 12 patients were selected from each group, and the interview time was 1 week±2 days after surgery. The results of quantitative and qualitative research that represented the same dimensions were compared and integrated for analysis. Results: Both the quantitative and qualitative research results showed that pain, cervical function, and nerve function of the intensive rehabilitation group were improved at 1 week after surgery. The quantitative research results revealed no significant difference in the VAS, mJOA, and NDI scores between the two groups at 3 months after surgery (P>0.05). Conclusion: The effect of postoperative intensive rehabilitation treatment was mainly reflected in the improvement of early postoperative function. It could improve pain, cervical function, and nerve function of patients after laminoplasty in the early postoperative period, but there was no significant difference in these parameters in any patients at 3 months after surgery. Trial registration: NCT, NCT05149404. Retrospectively registered 08/12/2021;
Long non-coding RNAs as the regulatory hubs in rice response to salt stress
Authors: Mansuri Raheleh Mirdar , Azizi Amir-Hossein , Shobbar Zahra-Sadat 
Published: July 2022

Abstract
Background: Salinity seriously constrains growth and fertility of rice worldwide. Long non-coding RNAs (lncRNAs) play crucial roles in plant abiotic stress response. However, salt responsive lncRNAs are poorly understood in rice. Results: Herein, differentially expressed lncRNAs (DE-lncRNAs) were identified in FL478 (salt tolerant) compared to its susceptible parent (IR29) using RNA-seq. In FL478 and IR29, 8724 and 9235 transcripts with length of >200 bp were nominated as potential lncRNAs, respectively. Rigorous filtering left four (in FL478) and nine (in IR29) DE-lncRNAs with only 2 DE-lncRNAs in common. ATAC-seq data showed that the genomic regions of all four lncRNAs in FL478 and 6/9 in IR29 are significantly accessible for transcription. Weighted correlation network analysis (WGCNA) revealed that lncRNA.2-FL was highly correlated with 173 mRNAs as trans-targets and a gene encoding pentatricopeptide repeat (PPR) protein was predicted as cis-target of lncRNA.2-FL. In silico mutagenesis analysis proposed the same transcription factor binding sites (TFBSs) in vicinity of the trans- and cis-regulatory target genes of lncRNA.2-FL, which significantly affect their transcription start site (TSS). Conclusions: This study provides new insights into involvement of the DE-lncRNAs in rice response to salt stress. Among them, lncRNA.2-FL may play a significant regulatory role in the salt stress tolerance of FL478.
AASM: Attribute based Advanced Security Model for Reliable Data Sharing in Cloud Computing
Authors: P. Anbumani , R Dhanapal 
Published: July 2022

Abstract
In present scenario, Cloud Computing is used in several applications and services, denotes the utilization of computational resources as a service based on user requirements through Internet. The computing model is based on data outsourcing, to data centers that are controlled by third parties. Though there are several advancements in Cloud Services and Applications, there are many security threats in Cloud. With that concern, this paper develops a novel model called Attribute based Advanced Security Model for Reliable Data Sharing in Cloud (AASM). The model integrates the Advanced Encryption Technique (AET) with Attribute based Signature (AS) for secure data sharing in Cloud. Moreover, the model provides efficient data control that effectively defines the following steps to process. Firstly, the model enforces encrypted access control aspect from the side of data_owner, with some advanced access privileges. Secondly, the user privacy can be effectively preserved with anonymous authentication model using AS that secures the user private data in efficient manner. With these implementations, the model secures the cloud providers, users and controls the malicious user attacks. The efficiency of the proposed model is determined with the factors such as time complexities, security, and accountability.
Investigation on the Relationship betweenPump Intensity Noise and Frequency Noisein Nd:YAG Lasers
Authors: Yuan Wen Hao , Zhang Chong Wu , Wang Chen , Huang Xin , Li Xu Ying , Zhang Jia Rui , Lin Xiang , Zhao Jian , Lu Ze Huang 
Published: July 2022

Abstract
Monolithic Nd: YAG lasers pumped by laser diodes have been widely used in precision measurement fields due to its low frequency noise and intensity noise. Previously, people found that the intensity noise of the pump laser would affect the frequency noise of the Nd: YAG lasers, but the cause has not been well explained so far. In this paper, we propose that this effect is thermally induced. The experimental results agreed well with the theoretical model predictions in up to 60 kHz frequency range. The finding can provide ideas for further reducing the frequency noise of Nd: YAG lasers. We get about 300 Hz linewidth in NPRO laser pumped by single laser diode.
Gapped electron liquid state in the symmetric Anderson lattice - Kondo insulator state
Authors: Karnaukhov Igor N. 
Published: July 2022

Abstract
In framework of a mean field approach we study the Kondo insulator state which is realized in the symmetric Anderson model at half filling. It is shown that the state of the Kondo insulator is realized in a lattice with a double cell, in which a gap electron liquid behaves like a gapless Majorana spin liquid. Local moments of d-electrons form a static Z 2-field in which band electrons move. The value of the gap in the spectrum of quasi-particle excitations decreases with increasing an external magnetic field and closes at its critical value. The behavior of the electron liquid in the state of the Kondo insulator is typical for an arbitrary dimension of the system. The proposed approach leads to the description of the Kondo insulator state without the need to resort to artificial symmetry breaking to alternative understanding of the physical nature of this phase state.
Analysis of early curative effect of TKA surgery strategy guided by personalized tibial prosthesis rotation alignment
Authors: Yan Yuhao , Liu Xuanze , Yan Mingsheng , Chen Ying , Xie Jun , Xiao Guoqing 
Published: July 2022

Abstract
Background
To explore the influence of individualized positioning of tibial prosthesis rotation alignment to guide total knee arthroplasty (TKA) surgery strategy on the early postoperative effect.
Method
A total of 60 patients who underwent TKA in our hospital from January 2019 to March 2020 were divided into two groups: personalized operation group and traditional operation group, with 30 patients each group. The general data such as age, sex, operation time, intraoperative blood loss and hospital stay were recorded. Range of motion (ROM), visual analogue scale (VAS), knee society score (KSS), The Western Ontario and McMaster Universities Arthritis Index (WOMAC), and Oxford knee score (OKS) were recorded before, 3 months and 12 months after operation and the vertical angle between APA and STEA' was θ, the mechanical axis of lower extremities (MA) and patellofemoral index (PFI) 3 months and 12months after operation were measured to evaluate the postoperative effect.
Results
3 months after operation, the ROM, VAS, KSS, vertical angle θ and PFI scores of personalized positioning group were (108.6 ± 8.27), (1.20 ± 0.56), (88.15 ± 2.54), (0.85 ± 1.08) and (0.97 ± 0.10) respectively were better than traditional operation group (102.80 ± 7.72), (2.20 ± 0.67), (83.60 ± 3.85), (7.12 ± 0.99), (1.34 ± 0.20). 12 months after operation, the ROM, VAS, KSS, vertical angle θ and PFI scores of personalized positioning group were (118.3 ± 7.26), (0.67 ± 0.48), (91.83 ± 1.74), (0.35 ± 1.03), (0.96 ± 0.15) respectively were better than traditional operation group (114.1 ± 8.09), (1.18 ± 0.83), (89.93 ± 2.50), (6.24 ± 0.69), (1.28 ± 0.19). There was no significant difference in MA, WOMAC and OKS after operation.
Conclusion
Personalized tibial prosthesis rotation alignment guide TKA strategy can more accurately obtain the prosthesis rotation alignment and lower limb force lines, and then guide TKA surgery, in order to achieve better results in the early postoperative period.
Perception of the impact of COVID-19 pandemics on cancer patients
Authors: Pires Mariana Rebordão , Pestana-Santos Adriana , Costa Cláudia Amorim , Caetano Ana Carlota , Monteiro Joana C. , Sousa Maria João , Pereira Tatiana Cunha , Pêgo António , Sousa Gabriela 
Published: July 2022

Abstract
Purpose
Significant changes in treatment centers were implemented during COVID-19 pandemics. Understanding how these alterations impacted cancer patients is a subject that needs to be investigated.
Methods
Patients who accepted to fill a hand paper questionnaire were included in this cross-sectional study. The questionnaire was distributed between March 19 and April 30, 2020 (first emergency state in Portugal) at the Portuguese Oncology Institute of Coimbra Francisco Gentil.
Results
A total of 100 patients participated in the study, of whom 66% were female. The median age was 61 years old [29–89]. Patients presented low education levels (65% with 9 or less years of schooling), lived together (83%) and were undergoing palliate treatments (59%). The most significant reported change in health care were inability of having an accompanying person in medical appointments (64%). Association with the level of education, household, type of solid cancer or therapeutic purpose was not verified (Creamer-V-indicator < 0.4). The major concerns reported were being infected by SARS-Cov-2 due to an immunosuppressed state (65%) and the security of self/family/friends (53%). Patients with lower education were more worried about developing COVID-19 (p = 0.001) and of having limited access to medical care (p = 0.047). Patients in a curative therapeutic approach were more concerned about employment situation (p = 0.031) and had higher anxiety levels (p = 0.047).
Conclusion
COVID-19 pandemic is having a great impact in patients with cancer, namely in those who have a lower education level, live alone or those who therapeutic approach is curative. The implementation of measures to manage the psychologic impact of COVID-19 is urgent.
Spatial distribution, zoning and depth effects on reef biodiversity at the largest Brazilian coastal Marine Protected Area
Authors: Pereira Pedro Henrique Cipresso , Lima Gislaine Vanessa , Silva Erandy Gomes , Pontes Antonio Vitor Farias , Côrtes Luis Guilherme , Sampaio Cláudio L. S. , Pinto Taciana Kramer , Belluci Marius , Cardoso Andrei Tiego Cunha , Normande Iran 
Published: July 2022

Abstract
The distribution of coral reef biodiversity is regulated by a series of natural variables and human induced factors such as depth, habitat availability, spatial variation, and management policies. However, spatial distribution patterns of coral reefs biodiversity are still scare on several areas, such as Southwestern Atlantic Ocean Marine Protected Areas (MPAs) even though better management strategies worldwide could be supported by species distribution data. A total of 84 reefs spatially distributed around the MPA Costa dos Corais (Northeastern Brazil) and ranging from 1 to 30 m depth were sampled during the present study. The survey of biological data was obtained through SCUBA diving using a 20 m belt transect methodology. Our study is the first one to demonstrated biodiversity spatial distribution of the largest Brazilian coastal MPA Costa dos Corais biodiversity and the importance of zoning as a major coral reef conservation strategy in Brazil, additionally shown how depth influence fish and coral biodiversity. Hence, management and zoning strategies have influenced the structure of coral reef communities with a series of different ecological effects highlighting the importance of those strategies for Southwestern Atlantic Ocean MPAs.
EGFR as a potent CAR T target in Triple Negative Breast Cancer Brain Metastases
Authors: Akhavan David , Subham Siddharth , Jeppson John D. , Worcester Colette , Schatmeyer Bryan , Zhao Jie , Madan Rashna , Lakis Nelli , Kimler Bruce , McGuirk Joseph P. , Chen Ronald C. , Stecklein Shane R. 
Published: July 2022

Abstract
Purpose There is currently no curative treatment for patients diagnosed with triple-negative breast cancer brain metastases (TNBC-BM). CAR T cells hold potential for curative treatment given they retain the cytolytic activity of a T cell combined with the specificity of an antibody. In this proposal we evaluated the potential of EGFR re-directed CAR T cells as a therapeutic treatment against TNBC cells in vitro and in vivo . Methods We leveraged a TNBC-BM tissue microarray and a large panel of TNBC cell lines and identified elevated epidermal growth factor receptor (EGFR) expression. Next, we designed a second-generation antiEGFR CAR T construct incorporating a clinically relevant mAb806 tumor specific single-chain variable fragment (scFv) and intracellular 4-1BB costimulatory domain and CD3ζ using a lentivirus system and evaluated in vitro and in vivo anti-tumor activity. Results We demonstrate EGFR is enriched in TNBC-BM patient tissue after neurosurgical resection, with six of 13 brain metastases demonstrating both membranous and cytoplasmic EGFR. Eleven of 13 TNBC cell lines have EGFR surface expression ≥85% by flow cytometry. EGFR806 CAR T treated mice effectively eradicated TNBC-BM and enhanced mouse survival (log rank p<0.004). Conclusion Our results demonstrates anti-tumor activity of EGFR CAR T cells against TNBC cells in vitro and in vivo . Given EGFR CAR T cells are currently undergoing clinical trials in primary brain tumor patients without obvious toxicity, our results are immediately actionable against the TNBC-BM patient population.
Benefits and Barriers of Utilizing E-portfolios in EFL Writing
Authors: Cheng Ying-Hsueh 
Published: July 2022

Abstract
Research into portfolio assessment highlights its potential to help L2 writers organize, reflect on, and take charge of their own learning. Although many have investigated L2 students’ use of e-portfolios as alternative assessment, little attention is paid to EFL learner perceptions. This study aims to explore EFL college writers’ perceived benefits and barriers of e-portfolio creation and evaluation. A platform, Wix.com, was utilized for students to build up their e-portfolios to showcase their written work. This study followed two classes of sophomore students (n = 29) for two academic years. To gain insights into students’ perceptions, both quantitative and qualitative data were collected, including a questionnaire, students’ reflections, and interviews. Results indicate that most students valued the practices of creating and maintaining their own Wix-based e-portfolios which displayed their development and growth as writers and learners over time. Although some students reported barriers to constructing the Wix-based e-portfolios, they considered the e-portfolio approach innovative, integrated, and reflective. This study concludes with implications for educators who wish to integrate the portfolio approach through web-based platforms.
The CT-based intratumoral and peritumoral machine learning radiomics analysis in predicting lymph node metastasis in rectal carcinoma
Authors: Yuan Hang , Xu Xiren , Tu Shiliang , Chen Bingchen , Wei Yuguo , Ma Yanqing 
Published: July 2022

Abstract
Background: To construct clinical and machine learning nomogram to predict the lymph node metastasis (LNM) status of rectal carcinoma (RC) based on radiomics and clinical characteristics. Methods: 788 RC patients were enrolled from January 2015 to January 2021, including 303 RCs with LNM and 485 RCs without LNM. The radiomics features were calculated and selected with the methods of variance, correlation analysis, and gradient boosting decision tree. After feature selection, the machine learning algorithm of Bayes, k-nearest neighbor (KNN), logistic regression (LR), support vector machine (SVM), and decision tree (DT) were used to construct prediction models. The clinical characteristics combined with intratumoral and peritumoral radiomics was taken to develop a radiomics and machine learning nomogram. The relative standard deviation (RSD) was used to predict the stability of machine learning algorithm. The area under curves (AUCs) with 95% confidence interval (CI) were calculated to evaluate the predictive efficacy of all models.Results: To intratumoral radiomics analysis, the RSD of Bayes was minimal compared with other four machine learning algorithms. The AUCs of arterial-phase based intratumoral Bayes model (0.626 and 0.627) were higher than these of unenhanced-phase and venous-phase ones in both the training and validation group.The AUCs of intratumoral and peritumoral Bayes model were 0.656 in the training group and were 0.638 in the validation group, and the relevant Bayes-score was quantified. The clinical-Bayes nomogram containing significant clinical variables of diameter, PNI, EMVI, CEA, and CA19-9, and Bayes-score was constructed. The AUC (95%CI), specificity, and sensitivity of this nomogram was 0.828 (95%CI, 0.800-0.854), 74.85%, and 77.23%.Conclusion: Intratumoral and peritumoral radiomics can help predict the LNM status of RCs. The machine learning algorithm of Bayes in arterial-phase performed better in consideration of terms of RSD and AUC. The clinical-Bayes nomogram better predicted the LNM status of RCs.
Assessing and comparing the emotional intelligence in generalist and psychiatric nurses
Authors: Alshowkan Amira , Kamel Neama , Alghamdi Rayanah 
Published: July 2022

Abstract
Aim: Emotional intelligence (EI) is linked to individual well-being and has a positive effect on patient care. This study was aimed at assessing and comparing the EI levels demonstrated by students at one university in Saudi Arabia who studied had psychiatric and mental health nursing and those who had studied nursing fundamental of nursing courses but had not yet taken psychiatric nursing courses. Design: A descriptive and comparative study designMethods: Data were collected from all second- and third-year nursing students using the Schutte Self-Report Emotional Intelligence Test (SSEIT). Results: Finding indicate that students who had studied only nursing fundamentals demonstrated lower EI than those who were completing psychiatric and mental health nursing courses. Moreover, increased EI was related to the education level of the participant’s father and being the eldest child in the family.