bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic Simulation Analysis and Experimental Study of an Industrial Robot with Novel Joint Reducers
Authors: Wang Shisong , Deng Xingqiao , Feng Huiling , Ren Keqi , Li Fan , Liu Yucheng 
Published: August 2022

Abstract

Zero-backlash high precision roller enveloping reducers (ZHPRER) possess a wide array of potential applications in the field of industrial robot because of their high precision and efficiency. This paper presents a pilot study to verify the applicability of this type of reducers in industrial robots. An industrial robot was designed, whose joint reducers were the roller enveloping reducers. A dynamic model for this robot which accounts for the dynamic responses of the reducers was also established using multibody dynamics. This dynamic model was then used for analyzing the dynamic behavior of the joint reducers and the body of the robot under different operating conditions. Simulation results yielded from the developed model were verified by comparing them with the data obtained from experiments. The present study for the first time confirms the evident advantages of ZHPRER for industrial robotic applications. Meanwhile, the proposed dynamic model for the industrial robot provides theoretical support for the subsequent design of error compensation control.
Can contextual factors affect match running performance in elite youth soccer players? A case study in Brazil
Authors: Gonçalves Luiz Guilherme , Nobari Hadi , Rites Alex Ambrosio , Nakamura Fábio Yuzo , Garcia Gabriel Rodrigues , Aquino Rodrigo 
Published: August 2022

Abstract
This study investigated the effects of match location (i.e., home vs. away), quality of opposition (i.e., weak vs. intermediate vs. strong), and the match outcome (i.e., loss vs. draw vs. win) on match running performance of starters and non-starters young elite Brazilian soccer players. Thirty-five male outfield players were observed during the U20 Brazilian National League and were classified into starters (played ≥ 60 minutes: n = 133 individual observations) and non-starters (played < 60 minutes; n = 59 individual observations). The distance- and accelerometry-based measures were recorded during 17 matches using a global position system (10 Hz). The main results were: i) non-starters covered greater absolute sprinting distance (SPRabs: p = 0.02; Effect Size [ES] = large), SPR distance relative per minute played (SPRrel: p = 0.005; ES = very large), and high-acceleration and deceleration relative per minute played (ACC+DECrel: p < 0.001; ES = very large) in the home compared to away matches; ii) in starters, matches played against strong opponents resulted in higher values of absolute total distance in high-speed running (HSRabs) (p = 0.04; ES = very large) and high-speed running per minute played (HSRrel) (p = 0.04; ES = very large) compared to matches played against weaker opponents; iii) non-starters covered greater absolute total distance in matches against strong vs. intermediate opponents (p = 0.02; ES = very large); iv) starters (p = 0.03; ES = moderate) and non-starters (p = 0.04; ES = very large) covered greater absolute ACC+DEC distances in matches that resulted in win vs. draw. These findings suggest that match contextual factors influenced both starters and non-starters young elite soccer players. Coaches and practitioners should consider these aspects when interpreting the match running outputs and use them to inform team tactics, selection, and substitution strategies.
Abbreviations
GPS: global positioning systems. TD: total distance covered. HSR: total distance covered under high-speed running. Acc: total distance covered under high acceleration. Dec: total distance covered under high deceleration. Abs: absolute. Rel: relative. ES = effect size.
Mathematical formulation of the purchase funnel by using knowledge space theory
Authors: Lin Yung-Tzu , Chang Chuan-Yi , Cheng Shein-Yung , Lin Meng-Yun 
Published: August 2022

Abstract
The retail industry provides customers with goods or services. Analyzingthe purchase behavior of customers is critical for expanding thebusiness. Therefore, managing the repurchase intention of customersis crucial. A sequence of purchase behaviors by each customer constitutesa set of purchase customer journeys (purchase CJs), whichdetail purchase pathways and repurchase behaviors. Purchase CJs arethe actual retail transaction data. This study investigated purchaseCJs and proposed a purchase funnel called CJ graph (CJG) bymeasure theory and knowledge space theory with actual retail transactiondata. To achieve this objective, a customer journey block (CJB),denoting “touchpoint,” is defined as a series of purchase behaviors duringa period and used as the base of this method. Each touchpointis allotted a measurable function, named purchase measure (PM).By integrating all the CJBs of purchase CJs, the purchase measuregraph (PMG) can be constructed as the primary structure ofthe PM knowledge structure. Finally, when all CJs are coordinatizedwith CJ codes, knowledge space theory is used to develop the customerjourney graph (CJG). In this method, knowledge bases are usedas the spanning framework of the CJ knowledge space, and the filteringproperty of the purchase funnel is illustrated. Furthermore, to validate the feasibility of the proposed method, a set of two-year andone million transactions retail data generated from more than thirty-sixthousand customers was segmented by recency, frequency, and monetary(RFM) model. Thus, the corresponding PMGs and CJGs of various(12, here) customer segments are detailed, and the resultant knowledgebases of the primary purchases and secondary re-purchases are appliedto analyze and predict the customer purchase behaviors accurately.
Molecular interaction studies on thermophysical and excess properties of formamide with n-propanol
Authors: Navarkhele Aishwarya , Ambewadikar Digvijayshree , Jadhav Sujata , Navarkhele Vaijanath 
Published: August 2022

Abstract

Static dielectric constants at (293.15, 298.15, 303.15 K), densities and refractive indices at (293.15 K) of binary mixtures of formamide with n-propanol have been measured over the entire range of mole fractions. The variation in measured parameters with respect to temperature and composition are discussed in detail. Excess dielectric constants, Kirkwood and Bruggeman factors were estimated from experimental dielectric data to confirm molecular structure, orientation of electric dipoles, intermolecular interaction and hydrogen bonding in the binary mixtures. Excess molar volume VE, deviation in molar refraction ΔR, related thermophysical parameters, excess properties have also been estimated and analyzed. The nonlinear variation in dielectric constants, deviation in linear relation in Bruggeman factor, negative VE and ΔR suggest the presence of molecular interaction and formation of hydrogen bonds between formamide and n-propanol molecules.
Disease Burden of Prostate Cancer from 2014 to 2019: Estimation from the Global Burden of Disease Study 2019 and Medical Expenditure Panel Survey.
Authors: Li Yiyuan , Lin Shen , Lin Dong , Zhong Lixian , Wu Yajing , Xie Chen , Luo Shaohong , Huang Xiaoting , Xu Xiongwei , Weng Xiuhua 
Published: August 2022

Abstract
Purpose
To evaluate the disease burden of prostate cancer (PC), and assess key influencing factors associated with the disease expenditures of PC in the US.
Methods
The total deaths, incidence, prevalence, Disability-Adjusted Life Years of prostate cancer were obtained from the Global Burden of Disease Study 2019. The Medical Expenditure Panel Survey was used to estimate the healthcare expenditures and productivity loss, and to investigate the payment and utilization pattern of healthcare resources in the US. A multivariable logistic regression model was conducted on medical expenditure to assess key influencing factors for the expenditures.
Results
For patients aged 49 and above, the burden in all age groups maintain a modest increase trend over the six-year period. The estimated annual medical expenditure ranged from $24.8 to $39.2 billion from 2014 to 2019. The patients’ productivity loss is approximately $1,200 per patient per year. The top three major components of medical costs were hospital inpatient stays, prescription medicines, and office-based visits. Medicare represented the largest source of payment for survivors. In term of drug consumptions, genitourinary tract agents (57.0%) and antineoplastics (18.6%) are the primary treatment drugs for these patients. High medical expenditures were positively associated with age (p = 0.005), having private health insurance (p = 0.016), more comorbidities, currently no smoke (p = 0.001), and patients’ self-perceived in fair/poor health status (p < 0.001).
Conclusions
From 2014 to 2019, the national real-world data of PC revealed that the disease burden in the US kept increasing, which were partly associated with patient characteristics.
Identifying novel interactions of the colon-cancer related APC protein with Wnt-pathway nuclear transcription factors
Authors: Al-Thani Nayra M. , Schaefer-Ramadan Stephanie , Aleksic Jovana , Mohamoud Yasmin A. , Malek Joel A. 
Published: August 2022

Abstract
Background
Colon cancer is often driven by mutations of the adenomatous polyposis coli (APC) gene, an essential tumor suppressor gene of the Wnt β-catenin signaling pathway. APC and its interactions in the cytoplasm have been well studied, however various groups have also observed its presence in the nucleus. Identifying novel interactions of APC in the Wnt pathway will provide an opportunity to better understand the nuclear role of APC and ultimately identify potential cancer treatment targets.
Methods
We used the all-vs-all sequencing (AVA-Seq) method to interrogate the interactome of protein fragments spanning most of the 60 Wnt β-catenin pathway proteins. Using protein fragments identified the interacting regions between the proteins with more resolution than a full-length protein approach. Pull-down assays were used to validate a subset of these interactions.
Results
74 known and 703 novel Wnt β-catenin pathway protein-protein interactions were recovered in this study. There were 8 known and 31 novel APC protein-protein interactions. Novel interactions of APC and nuclear transcription factors TCF7, JUN, FOSL1, and SOX17 were particularly interesting and confirmed in validation assays.
Conclusions
Based on our findings of novel interactions between APC and transcription factors and previous evidence of APC localizing to the nucleus, we suggest APC may compete and repress CTNNB1. This would occur through the binding of the transcription factors (JUN, FOSL1, TCF7) to regulate the Wnt signaling pathway including through enhanced marking of CTNNB1 for degradation in the nucleus by APC binding with SOX17. Additional novel Wnt β-catenin pathway protein-protein interactions from this study could lead researchers to novel drug designs for cancer.
A novel process to reduce obstructive azoospermia recurrence after transurethral seminal vesiculoscopy
Authors: Pang Kun , Zhu Zuobin , Pan Deng , Ma Yuyang , Xu Hao , Chen Bo , Feng Harry , Han Conghui 
Published: August 2022

Abstract
Introduction
Transurethral seminal vesiculoscopy (TSV) is a common treatment for obstructive azoospermia but has a high rate of recurrence.
Aim
Introduce a new method involving indwelling double-J (D-J) tubes in seminal vesicles during TSV in order to reduce recurrent rate and refractory obstructive azoospermia.
Methods
A prospective study was performed to compare the effects and complications of patients treated with or without indwelling D-J tubes after TSV. General information and TSV Surgical parameters, including age, body mass index, preoperational antibiotics, history of urinary tract disease, surgical time length (STL) and complications during and after the surgery, were collected and used as baseline information. The current study compared the postoperative complications and postoperative hospital days (PHD), as well as the recurrence rate of haemospermia between the two groups.
Results
A total of 59 cases, including 28 patients who underwent treatment with indwelling D-J tubes and 31 patients who underwent treatment with the standard TSV procedure, were enrolled in this study. There was no statistically significant difference in baseline data, Intraoperative and postoperative complications and postoperative hospital days between the two groups (p > 0.05), and there was a statistically significant difference in STL and recurrence rate between the two groups (p < 0.05), the recurrence rate was lower in D-J group (21.4%) than that of control group (41.9%). This technique can effectively suppress the appearance of the first recurrence peak after TSV.
Conclusion
We introduced a new technique of indwelling D-J tubes for TSV to reduce the recurrence rate and refractory obstructive azoospermia.
A method for planning disaster risk management and calibrating disaster relief efforts: application to the 2009 and 2022 Tonga tsunamis
Authors: Thomas Bruce Enki Oscar , Roger Jean , Gunnell Yanni , Ashraf Salman 
Published: August 2022

Abstract
Coastal communities are highly exposed to ocean- and climate-related hazards but often lack an accurate population and infrastructure database. On January 15, 2022 and for many days thereafter, the Kingdom of Tonga was cut off from the rest of the world by a destructive tsunami associated with the Hunga Tonga Hunga Ha’apai volcanic eruption. This situation was made worse by COVID-19-related lockdowns and no precise idea of the magnitude and pattern of destruction incurred. The occurrence of such events in remote island communities highlights the need for (1) precisely knowing the distribution of residential and public buildings, and (2) evaluating what proportion of those would be vulnerable to a tsunami. A GIS-based dasymetric mapping method, previously tested in New Caledonia for assessing and calibrating population distribution at high resolution, is improved and implemented in less than a day to jointly map population clusters and critical elevation contours based on runup scenarios, and is tested against destruction patterns independently recorded in Tonga after the two recent tsunamis of 2009 and 2022. Results show that 62% of the population of Tonga lives in well-defined clusters between sea level and the 15 m elevation contour. The patterns of vulnerability thus obtained for each island of the archipelago allow exposure and potential for cumulative damage to be ranked as a function of tsunami magnitude and source-area. By relying on low-cost tools and incomplete datasets for rapid implementation in the context of natural disasters, this approach works for all types of natural hazards, is easily transferable to other insular settings, can assist in guiding emergency rescue targets, and can help to elaborate future land-use planning priorities for disaster risk reduction purposes.
Elimination of Praziquantel-Resistant Dipylidium caninum with Nitroscanate in a Mixed-Breed Dog: a Novel Application of Capsule Endoscopy
Authors: Loftus John P. , Acevedo Andrew , Bowman Dwight D. , Liotta Janice L. , Wu Timothy , Zhu Melinda 
Published: August 2022

Abstract
Background
Praziquantel is the drug of choice for treating Dipylidium caninum in dogs; however, resistance is possible.
Methods
Microscopy was used to identify Dipylidium spp. segments and capsule endoscopy visualized adult tapeworms within the intestinal tract.
Results
An 18-month-old spayed female terrier mix was presented due to diarrhea, hematochezia, and weight loss. The dog received appropriate anthelmintic therapy for Giardia spp., Ancylostoma spp., and Dipylidium spp. The dog’s clinical signs resolved, and elimination of Ancylostoma spp. was confirmed by subsequent fecal analysis. However, Dipylidium spp. segments were repeatedly present in the stool. Observation of the segments under light microscopy confirmed the presence of adult Dipylidium spp. Several medications, including flea treatments, praziquantel, and epsiprantel, were unsuccessful in eliminating the organism. A single dose of nitrosconate was administered and eliminated Dipylidium spp. infection in the dog.
Conclusions
Nitrosconate can be a safe and effective treatment for praziquantel-resistant dipylidiasis in dogs. The novel application of capsule endoscopy confirmed anthelmintic efficacy.
Does surgical position affect infective complications in percutaneous nephrolithotomy?
Authors: Kasap Yusuf , Senel Samet , Uzun Emre , Polat Muhammed Emin , Koudonas Antonios , Ozden Cuneyt 
Published: August 2022

Abstract
The downward orientation of the access sheath during supine percutaneous nephrolithotomy (PCNL) allows the faster evacuation of fluids and stone fragments. It theoretically can contribute to the reduction of the high intrarenal pressure-associated complications. We aimed to investigate whether there is a difference between prone and supine PCNL in terms of infective complications. This retrospective study includes 182 patients who underwent supine and prone PCNL due to kidney stones in our clinic between April 2020 and May 2022. Demographic (age, sex, body mass index, comorbidities), radiological (cumulative stone burden, stone density, number of stones, stone localization, stone laterality, presence of hydronephrosis), clinical (previous stone surgery, previous urinary tract) and perioperative (prone or supine position, surgery duration, hospitalization, success, non-infective and infective complications) data of all patients were evaluated. All patients were divided into two groups, the prone position group, and the supine position group. These two groups were compared in terms of pre and post-operative data above. Infective complications were observed in 16 (18%) patients in the prone position group and in 7 (7.5%) patients in the supine position group, and this difference was statistically significant (p = 0.034). Surgery duration (OR = 1.041;95% Cl = 1.021–1.061; p < 0.001), number of stones (OR = 4.09;95% Cl = 1.093–7.309; p = 0.036), previous urinary tract infection (OR = 6.272;95% CI = 1.936–9.317; p = 0.002) and prone position (OR = 4.511;95% CI = 1.265–7.087; p = 0.02) were found as independent risk factors for infective complications. Prone position was proved as an independent predictor of postoperative infectious events. Supine PCNL will be further adopted as the standard PCNL approach by a continuously growing proportion of endourologists.
Agriculture without paraquat is feasible without loss of productivity. Lessons learned from phasing out a highly hazardous herbicide
Authors: Stuart Alexander M. , Merfield Charles N. , Horgan Finbarr G. , Willis Sheila , Watts Meriel A. , Ramírez-Muñoz Fernando , U. Jorge Sánchez , Utyasheva Leah , Eddlestone Michael , Davis Mark , Neumeister Lars , Sanou Manoé R. R. , Williamson Stephanie 
Published: August 2022

Abstract
A small proportion of the thousands of pesticides on the market today are associated with a disproportionately high incidence of severe acute pesticide poisoning and suicide. Paraquat stands out as one of the most lethal pesticides in common use, frequently involved in fatal incidents due to suicides or accidental exposure. Even though paraquat has been banned in over 67 countries, it is still widely used in many others. Based on a literature review and consultation process, this paper identifies options for replacing paraquat and distils practical lessons from numerous successes around the world. Our aim is to support regulators, policy makers, agronomists and the supply chain sector with practical information related to phasing out paraquat. Production data consistently failed to show any negative impact of banning paraquat on agricultural productivity. A wide range of alternative approaches to weed management and crop defoliation are available, many of which do not rely on herbicides. Over 1.25 million farmers in low- and middle-income countries (LMICs) successfully produce a range of crops for private voluntary standards (PVS) in food and fibre supply chains which prohibit paraquat use. We conclude from the findings of this study that eliminating paraquat will save lives without reducing agricultural productivity. Less hazardous and more sustainable alternatives exist. To enhance successful adoption and uptake of these methods on a wide scale, farmers require training and support within an enabling policy environment.
The contribution of the donated human embryos suitable for production of embryonic stem cells to increase the quality of life: selection and preparation of embryos in Czech Republic
Authors: Ventruba Pavel , Ješeta Michal , Žáková Jana , Souralová Tereza , Koutná Irena , Hampl Aleš , Lousová Eva , Crha Igor , Ventruba Tomáš 
Published: August 2022

Abstract
Human embryonic stem cells (hESCs) are used in cell therapy mainly in targeted therapy for not yet curable diseases such as diabetes mellitus, spinal cord injury or Parkinson's disease. The aim of this study is the derivation of clinical-grade hESCs, usable in drug development, non-native medicine and cell therapy. Embryos were thawed, cultivated to the blastocyst stage if necessary, and subsequently assisted hatching was performed. From 1/2018 to 7/2020, 138 selected clients were asked for consent with the donation, of whom 52 did not respond, 19 terminated and 29 extended embryo storage. Only 38 clients (27.5%) agreed to donate their embryos for the derivation of hESCs. At the same time, personal communication with clients took place and another 17 embryo donors were obtained. A total of 160 embryos from 55 donors aged 26–42 years were collected. The embryos were frozen at blastocyst (33.1%) or morula (46.3%) stage. A total of 160 donated embryos were obtained. After preparation of 64 embryos, the embryoblast was isolated and subsequently cultured. Finally, 7 hESC lines were obtained, 4 research-grade lines and 3 clinical-grade lines, the first created in the Czech Republic.
Effects of crop rotation and soil tillage on suppressing the syndrome “basses richesses” vector Pentastiridius leporinus in sugar beet
Authors: Pfitzer René , Rostás Michael , Häußermann Patrick , Häuser Thilo , Rinklef André , Schrameyer Klaus , Voegele Ralf T. , Maier Johann , Varrelmann Mark 
Published: August 2022

Abstract
The planthopper Pentastiridius leporinus (Hemiptera: Cixiidae), is the most important vector of syndrome “basses richesses” (SBR) in sugar beet; it leads to severe economic losses. Planthoppers have probably adapted recently from reed grass (Phragmites australis) to sugar beet - winter wheat crop rotations. So far, no reliable vector control strategies are available. In this study, field assays were performed to test different soil tillage methods and crop rotations as potential management options. Barley, spring wheat, maize, bare soil and winter wheat (control) were grown using different soil tillage treatments (ploughing and cultivator) after sugar beet harvest. In five of seven field trial sites, reduced tillage did not differ from ploughing and, in two trial sites, it resulted in even higher numbers of emerging planthoppers. In nearly all field sites, consistent and significant reductions (up to 98.9%) of emerging adults were detected in the bare soil and maize treatments when compared to winter wheat. The survival and development of first instar nymphs were then studied on wheat, barley, and maize seedlings in the laboratory to confirm the field observations. The lowest survival was found in nymphs feeding on maize seedlings (4.2%), while 29.2% survived on barley, and 66.7% on wheat, over a period of 300 days. Almost 90% of nymphs in the maize treatment died after eight days. These results suggest that maize is a poor host for P. leporinus first instar nymphs. A combination of soil tillage and late sown specific spring crops are discussed as options for P. leporinus control.