bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of germicidal ultraviolet radiation UV-C on the quality of Apiaceae spices seeds
Authors: Kamel Reham M. , El-kholy Mohamed M. , Tolba Nermeen M. , Amer Alia , Eltarawy Ahmed Mohamed , Ali Liela M. 
Published: November 2022

Abstract
Background
Spices are susceptible to surface microbial contamination. Countries’ ban on ethylene oxide fumigation due to possible residual toxicity encouraged the usage of irradiation. Surface sterilization with low doses of ultraviolet radiation has been extensively researched as a safe, eco-friendly, and fast route. This study examines the quality of Apiaceae spices for consumption, including anise, fennel, caraway, and cumin, in response to germicidal ultraviolet radiation using a developed sterilization unit.

Methods
The influence of UV-C (254 nm, 10.5 mW/cm2) on the fungal and microbial count, germination percentage, respiration rate, phenolic content, essential oil, and the activity of antioxidant enzymes was investigated at exposure durations of 0–45 min in increments of 5 min. The treated seeds were packed in polyethylene bags in a naturally aerated storage room for 30 days before the inspection.

Results
The obtained data showed that UV-C stimulated seeds germination and increased respiration rate for all studied types. The 25 min of exposure exhibited the highest significant values compared to the control, considered a good indicator of seed vigor. In addition, UV-C exposure between 20 and 35 min promoted the accumulation of phenolic compounds and increased the oil content as a defense mechanism against radiation. Conversely, higher exposure to UV-C led to a significant reduction in phenolic and oil contents. Furthermore, the exposure to UV-C radiation enhanced the activity of antioxidant enzymes in terms of peroxidase and catalase, which progressively increased with increasing exposure durations, reached their peak at 25–30 min, and subsequently declined with extended exposure time was extended. In a similar pattern, exposure to UV-C radiation increased polyphenol oxidase activity to its highest level at 25 min, owing to the development of antioxidant protective mechanisms against oxidative stress.

Conclusion
UV-C irradiation in the range of 25–30 min is the most appropriate pretreatment to maintain the vitality of the examined seeds.

Graphical Abstract
Comparison of gastric reactance with commonly used perfusion markers in a swine hypovolemic shock model
Authors: Godinez-Garcia María M. , Soto-Mota Adrian , Catrip Jorge , Gaitan Ruben , Lespron Ma del C. , Molina Francisco J. , Falcón Miguel A. , Aranda Alberto , Tena Carlos A. , Zamudio Pedro , Briseño Ivan , Alvarez Rolando , Guillen Yazmin 
Published: November 2022

Abstract
Background
The gut has been hypothesized to be a protagonist tissue in multiple organ dysfunction syndrome (MODS) for the past three decades. Gastric reactance (XL) is a potential perfusion marker derived from gastric impedance spectroscopy (GIS), which is an emerging tool through which living tissue can be continuously measured to determine its pathophysiological evolution. This study aimed to compare the performance of XL [positive predictive values (PPV), negative predictive values (NPV), and area under the curve (AUC)] against commonly used perfusion markers before and during hypovolemic shock in swine subjects.

Methods
Prospective, controlled animal trial with two groups, control group (CG) N = 5 and shock (MAP ≤ 48 mmHg) group (SG) N = 16. Comparison time points were defined as T-2 (2 h before shock), T-1 (1 h before shock), T0 (shock), T1 (1 h after shock), and T2 (2 h after shock). Shock severity was assessed through blood gases, systemic and hemodynamic variables, and via histological examination for assessing inflammation-edema and detachment in the gastric mucosa. Macroscopic assessment of the gastric mucosa was defined in five levels (0—normal mucosa, 1—stippling or epithelial hemorrhage, 2—pale mucosa, 3—violet mucosa, and 4—marmoreal mucosa). Receiver Operating Characteristic (ROC) curves of perfusion markers and XL were calculated to identify optimal cutoff values and their individual ability to predict hypovolemic shock.

Results
Comparison among the CG and the SG showed statistically significant differences in XL measurements at T-1, T0, T1, and T2, while lactate showed statistically significant differences until T1 and T2. Statistically significant differences were detected in mucosa class (p < 0.001) and in inflammation-edema in the gastric body and the fundus (p = 0.021 and p = 0.043). The performance of the minimum XL value per subject per event (XL_Min) was better (0.81 ≤ AUC ≤ 0.96, 0.93 ≤ PPV ≤ 1.00, 0.45 ≤ NPV ≤ 0.83) than maximum lactate value (Lac_Max) per subject per event (0.29 ≤ AUC ≤ 0.82, 0.82 ≤ PPV ≤ 0.91, 0.24 ≤ NPV ≤ 0.82). Cutoff values for XL_Min show progressive increases at each time point, while cutoff values for Lac_Max increase only at T2.

Conclusions
XL proved to be an indirect and consistent marker of inadequate gastric mucosal perfusion, which shows significant and detectable changes before commonly used markers of global perfusion under the hypovolemic shock conditions outlined in this work.
Implementation and maintenance of infant dietary diversity in Zimbabwe: contribution of food and water insecurity
Authors: Koyratty Nadia , Mbuya Mduduzi N. N. , Jones Andrew D. , Schuster Roseanne C. , Kordas Katarzyna , Li Chin-Shang , Tavengwa Naume V. , Majo Florence D. , Chasekwa Bernard , Ntozini Robert , Humphrey Jean H. , Smith Laura E. 
Published: November 2022

AbstractBackgroundInadequate food and water resources negatively affect child health and the efficiency of nutrition interventions.MethodsWe used data from the SHINE trial to investigate the associations of food insecurity (FI) and water insecurity (WI) on mothers’ implementation and maintenance of minimum infant dietary diversity (MIDD). We conducted factor analysis to identify and score dimensions of FI (poor access, household shocks, low availability & quality), and WI (poor access, poor quality and low reliability). MIDD implementation (n = 636) was adequate if infants aged 12 months (M12) ate ≥ four food groups. MIDD maintenance (n = 624) was categorized into four mutually exclusive groups: A (unmet MIDD at both M12 and M18), B (unmet MIDD at M12 only), C (unmet MIDD at M18 only), and D (met MIDD at both M12 and M18). We used multivariable-adjusted binary logistic and multinomial regressions to determine likelihood of MIDD implementation, and of belonging to MIDD maintenance groups A-C (poor maintenance groups), compared to group D, respectively.ResultsLow food availability & quality were negatively associated with implementation (OR = 0.81; 0.69, 0.97), and maintenance (ORB = 1.29; 1.07, 1.56). Poor water quality was positively associated with implementation (OR = 1.25; 1.08, 1.44), but inconsistently associated with maintenance, with higher odds of infants being in group C (OR = 1.39; 1.08, 1.79), and lower odds of being in group B (OR = 0.80; 0.66, 0.96).ConclusionFood security should be prioritized for adequate implementation and maintenance of infant diets during complementary feeding. The inconsistent findings with water quality indicate the need for further research on WI and infant feeding.
Intrinsic Risk Factors for Ankle Sprain Differ Between Male and Female Athletes: A Systematic Review and Meta-Analysis
Authors: Mason Joel , Kniewasser Christoph , Hollander Karsten , Zech Astrid 
Published: November 2022

Abstract
Background
Ankle sprains remain prevalent across most team sports. However, despite divergent ankle sprain injury rates in male and female athletes, little is known about potential sex-specific risk factors for ankle sprain.

Objective
To systematically investigate the sex-specific risk factors for ankle sprain.

Methods
Combinations of the key terms were entered into PubMed, Web of Science, Embase and Cochrane Library databases, and prospective studies reporting ankle sprain risk factors in males or females were included for meta-analysis.

Results
Sixteen studies were eligible for inclusion, for a total of 3636 athletes (735 female) and 576 ankle sprains (117 female). Out of 21 prognostic factors, previous ankle sprain injury (odds ratio = 2.74, P < .001), higher body mass index (SMD = 0.50, P < 0.001), higher weight (SMD = 0.24, P = 0.02), lower isometric hip abduction strength (SMD = − 0.52, P < 0.0001) and lower dynamic balance performance (SMD = − 0.48 to − 0.22, P < 0.001–0.04) were identified as risk factors in male athletes. In female athletes, out of 18 factors eligible for meta-analysis, only lower concentric dorsiflexion strength was identified as a risk factor (SMD = − 0.48, P = 0.005).

Conclusion
This meta-analysis provides novel evidence for different risk factor profiles for ankle sprain injuries between female and male athletes. Further studies, particularly in female athletes, are needed to strengthen the evidence.
The prevalence of misusing over-the-counter and prescribed drugs in Syrian gymnasiums for performance-enhancing reasons: a cross-sectional study
Authors: Alkebbeh Linda , Alaryan Thurya , Saad Marie Claire , Alzeer Samar 
Published: November 2022

Abstract
Background
This study investigates the prevalence of misusing over-the-counter (OTC) and prescribed drugs in Syrian gymnasiums, in addition to types, sources of knowledge, and patterns of use. A structured questionnaire was distributed to 381 members of sports groups on social media, between April 2020 and February 2021. Data were analyzed using IBM SPSS software Version 26 for windows.

Results
A total of 133 participants (about 35%) stated they took OTC and prescribed drugs. Of those, 79 (11.8%) took proteins and amino acids, and 14 (3.7%) claimed they used 50 different products (mentioned 167 times) of anabolic steroids and other hormones (e.g., growth hormone and thyroxine). The most frequently used substance was testosterone (N =25, 15.56%), followed by thyroxine (N = 12, 7.18%) and stanozolol (N = 11, 6.58%). The source of knowledge was the Internet (48.6%) followed by friends (28.4%) and coaches (20.9%). Most users were males (61.6%) and had a bachelor’s university degree (64%). All anabolic steroid users (N = 14) practiced bodybuilding. Statistically significant relationships were found between the usage of anabolic steroids, proteins, and amino acids with each of the monthly income, frequency of training, level of training, and gender. Users claimed that they got benefits from taking these substances, and the majority of users (about 70%) did not experience any adverse effects.

Conclusions
Our results showed significant differences compared to neighboring countries, regarding attitudes towards misusing OTC and prescribed medications.
Impact of obstructive sleep apnea on platelet activation and development of silent brain infarctions
Authors: Abd El-Razek Reda , Abou Hagar Ahmed , Orabi Marwa , Moawad Sabry , El-Samahy Mohamed 
Published: November 2022

Abstract
Background
Obstructive sleep apnea (OSA) is a unique potent predictor for stroke compared to other predictors. By aiding in the adherence of leukocytes and platelets, soluble P-selectin (sP-selectin) contributes to the development of ischemic stroke. The objective of this study was to investigate the independent impact of OSA on platelet activation and development of silent brain infarction. Twenty-four OSA patients and 24 controls were studied in a case–control study, who underwent one-night polysomnography, magnetic resonance imaging for evaluation of silent brain infarctions (SBI), measurement of serum (sP-selectin) levels for assessment of increased platelet activation and C-reactive protein (CRP) serum levels.

Results
Out of 24 patients, 5 (20.8%) had mild OSA and 8 (33.3%) had moderate and 11 (45.8%) had severe OSA. Serum levels of sP-selectin were statistically significantly higher in moderate and severe groups (p < 0.001). Eleven (57.9%) patients in moderate and severe OSA had SBI. Fifty percent of patients with moderate OSA had elevated serum sP-selectin and 25.0% of them had SBI and 81.8% of severe OSA patients had elevated serum sP-selectin and 81.8% of them had SBI. Patients with mild OSA and controls had no SBI and normal serum sP-selectin level. CRP was statistically significantly higher in moderate and severe OSA groups (16.6% and 45.8%) than the mild and control groups (4.1% and 0%) (p < 0.001).

Conclusion
Moderate and severe obstructive sleep apnea were associated independently with elevated serum sP-selectin reflecting increased platelet function, elevated inflammatory marker CRP and an increased risk of silent brain infarctions.
Comparing risk-based fuel treatment prioritization with alternative strategies for enhancing protection and resource management objectives
Authors: Thompson Matthew P. , Vogler Kevin C. , Scott Joe H. , Miller Carol 
Published: November 2022

Abstract
Background
Advances in fire modeling help quantify and map various components and characterizations of wildfire risk and furthermore help evaluate the ability of fuel treatments to mitigate risk. However, a need remains for guidance in designing landscape-scale fuel treatments with protection objectives, resource management objectives, and wildfire response in mind. It is also important to consider how human factors related to risk tolerance may affect opportunities to manage fire. We build on these themes to illustrate an approach for examining whether, and how, fuel management can simultaneously minimize housing exposure while maximizing area suitable for expansion of beneficial wildfire. We generate multiple hypothetical post-treatment conditions according to distinct treatment prioritization schemes (Housing Protection, Federal Transmission, Random) and variable treatment extents and compare performance across strategies for a 8.5 million ha case study landscape in north-central New Mexico, USA.

Results
In general, we find that treating near housing units can provide the greatest level of protection relative to treating more remote wildlands to reduce transmission potential. Treating on federal lands to reduce federal transmission was highly effective at reducing exposure from federal fires and at expanding opportunities for beneficial fire but contributed comparatively little to reducing housing exposure from all fires. We find that treatment extents as low as 2.5–5% can yield significant benefits with spatially optimized strategies, whereas the random strategy did not perform comparably until reaching a much larger treatment extent. Increasing risk tolerance for housing exposure expanded the area suitable for managed fire, while decreasing risk tolerance for beneficial fire opportunity and flame length probability shrunk the area suitable for managed fire.

Conclusions
This work provides a contribution in terms of explicitly framing risk analysis and fuel treatment design around federal land and resource management objectives and adds to the knowledge base for designing effective landscape fuel treatment strategies that can protect communities and expand beneficial wildfire on a fire-prone landscape. Successful integration of these themes requires embracing all pillars of the National Cohesive Wildland Fire Management Strategy, including coordinated management of fuels on various ownerships, home ignition zone mitigation, and cross-boundary fire response planning that can guide fire operations in reducing transmission and expand response options.
The gut-brain axis in ischemic stroke: its relevance in pathology and as a therapeutic target
Authors: Benakis Corinne , Liesz Arthur 
Published: November 2022

AbstractThe gut contains the largest reservoir of microorganisms of the human body, termed as the gut microbiota which emerges as a key pathophysiological factor in health and disease. The gut microbiota has been demonstrated to influence various brain functions along the “gut-brain axis”. Stroke leads to intestinal dysmotility and leakiness of the intestinal barrier which are associated with change of the gut microbiota composition and its interaction with the human host. Growing evidence over the past decade has demonstrated an important role of these post-stroke changes along the gut-brain axis to contribute to stroke pathology and be potentially druggable targets for future therapies. The impact of the gut microbiota on brain health and repair after stroke might be attributed to the diverse functions of gut bacteria in producing neuroactive compounds, modulating the host’s metabolism and immune status. Therefore, a better understanding on the gut-brain axis after stroke and its integration in a broader concept of stroke pathology could open up new avenues for stroke therapy. Here, we discuss current concepts from preclinical models and human studies on the bi-directional communication along the microbiota-gut-brain axis in stroke.
Investigating the effect of loading on the governing equation at the split region for a semi-infinite crack in an orthotropic material under antiplane loading
Authors: Emenogu Ndubueze G. 
Published: November 2022

AbstractMost often there is a great disparity between experimental results and analytic results. Before now under great disparity, researchers kept suspecting the experimental procedures without investigating whether their analytic solution actually satisfy the governing equation. When a body in a plane is under loading, the loading splits the plane into regions, and the governing equation must be satisfied at these regions for the derived solution to be true. In this paper, I considered a homogeneous infinite orthotropic material containing a semi-infinite crack. A longitudinal shear load of magnitude Q is applied on the crack front. The displacement field in closed form is obtained. A verification of this solution at the split regions is carried out and shown to satisfy the governing differential equation.
Outcome of Wilson’s disease in Bangladeshi children: a tertiary center experience
Authors: Mahmud Salahuddin , Gulshan Jahida , Baidya Madhabi , Rashid Rafia , Tasneem Farhana , Hasan Ahmed Rashidul , Farhana Tanzila , Ahmed Syed Shafi 
Published: November 2022

Abstract
Background
Wilson disease (WD) is an inherited disorder of copper metabolism commonly involving the liver, cornea, and brain. Its incidence is increasing day by day worldwide. Early diagnosis and prompt treatment are the key for best outcome.

Material and methods
A cross-sectional descriptive study was done from January 2014 to December 2019. Sixty children of both genders between 3 and 18 years were diagnosed by clinical and laboratory profile meeting selected criteria.

Results
Mean age was 8.42 ± 2.6 years and male female ratio was 1.5:1. Consanguinity of marriage was found in 38.3% cases. Seventy percent of cases were hepatic, 16.7% were neuropsychiatric, 5.0% were hepatic with neuropsychiatric, and 8.3% cases were manifested asymptomatically. Asymptomatic and hepatic WD were reported between 3 and 10 years and most of the neuropsychiatric and hepatic with neuropsychiatric manifested after 10 years of age. More than 50% cases improved, a little more than 20% children died, 18.4% were unchanged and 6.6% were hepatic added neuropsychiatric manifestations. Most of the asymptomatic (100%) and hepatic (61.9%) cases improved. High mortality was found with 76.9% cases of acute liver failure (ALF), 7.7% case of chronic liver disease (CLD) and 25% cases of CLD with portal hypertension (CLD and PH). Most of the neuropsychiatric cases (90.0%), and approximately two-third (66.6%) of hepatic with neuropsychiatric cases remained unchanged. Neuropsychiatric manifestations were added in 15.4% cases of CLD and 25% cases of CLD with PH patient. The treatment was well tolerated in 66% children without any side effects. Low WBC (6.3%) and platelet count (4.3%), vomiting (6.3%), anorexia (4.3%), loss of taste (4.3%), rash (4.3%), and proteinuria (2.1%) were found in few cases.

Conclusion
Majority of the children were presented with hepatic manifestations. More than half of patients with WD treated by D-penicillamine (DP) were improved. Significant mortality was found in acute liver failure whereas neuropsychiatric presentations had persistent abnormalities. No major side effects of DP was observed in most of the cases. Early diagnosis and prompt treatment were crucial for better outcome.
Micronutrient deficiency among patients with ulcerative colitis
Authors: Hussien Amany , El-Moniem Sawsan Abd , Tawhid Ziyad , Altonbary Ahmed 
Published: November 2022

AbstractBackground and aimMalnutrition is a common problem among patients with inflammatory bowel disease and up to 18–62% of ulcerative colitis (UC) patients were reported to be malnourished. This study aimed to assess micronutrient status among naïve UC patients and its correlation with disease severity.MethodsA prospective case-control study carried out on 46 patients who visited our endoscopy unit between April 2019 and April 2021. The patients were classified into 3 groups of mild, moderate, and severe UC based on colonoscopy findings, and histopathological examination. Serum was collected and assayed for levels of iron, magnesium, zinc, selenium, and copper.ResultsForty-six (17 male, 29 female) patients divided into 2 groups (23 naïve UC patients and 23 healthy individuals) with the mean age of 32 years were included in the study. The serum levels of magnesium, zinc, and selenium were significantly lower in the UC group (p< 0.001, 0.018 and < 0.001, respectively). However, iron and copper levels were not significantly different between the 2 groups. In discriminating severe from mild-moderate UC cases, there was a statistically significant result of magnesium at cutoff 1.8 or less in discriminating severe from mild to moderate UC cases with an AUC of 0.950 andpvalue of < 0.001.ConclusionMicronutrients should be assessed in patients in UC patients to alert to the fact that correction of these deficiencies could facilitate achievement of remission. Further research is needed to confirm if magnesium levels could serve as a predictor of the disease severity.
Thoracic air leak syndrome as the sole manifestation of chronic lung graft-versus-host disease: a case report
Authors: Nair Avinash Anil , Raja Arshad , Devasia Anup Joseph , Vimala Leena Robinson , Gupta Richa , Thangakunam Balamugesh , Mathews Vikram 
Published: November 2022

Abstract
Background
Thoracic air leak syndrome (TALS) is a rare complication associated with chronic lung graft-versus-host disease (GVHD) and bronchiolitis obliterans syndrome (BOS). In the present case, TALS was the sole pulmonary manifestation of GVHD.

Case presentation
A 30-year-old woman presented with dyspnea on exertion and swelling of the neck and face after allogeneic stem cell transplantation for acute myeloid leukemia. She was found to have subcutaneous emphysema, and chest imaging suggested pneumomediastinum, with normal lung parenchyma. Her clinical and radiological findings indicated TALS. There were no other features suggestive of lung GVHD. Her condition improved with conservative management and increased immunosuppression. However, she subsequently had two relapses, developed severe infection and pneumothorax, and died.

Conclusions
The present case report illustrates a unique presentation of TALS, a rare complication of GVHD, in a post-stem cell transplant patient. It highlights the challenges in the diagnosis and management of this condition.