bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep vein thrombosis in patients with patellar fractures: Assessing incidence rates and identifying risk factors
Authors: Yang Shuo , Zhang Erdong , Li Ziping , Long Yubin , Li Yiran , Zhang Jiaqi , Wang Fei , Liu Lin , Wang Tao , Guo Junfei , Hou Zhiyong 
Published: February 2025

Background
Deep Vein Thrombosis (DVT) represents a significant complication following orthopedic injuries, particularly patellar fractures. Despite the prevalence, comprehensive studies assessing the incidence rates and identifying specific risk factors in patellar fracture patients are limited.

Methods
This retrospective analysis reviewed electronic medical records from 3311 patients treated for patellar fractures at two tertiary hospitals between November 2013 and January 2023. The study focused on patient demographics, fracture characteristics, comorbidities, and laboratory parameters to evaluate the incidence and predictors of DVT. DVT prophylaxis measures and diagnostic criteria, including Doppler Ultrasound Scans, were rigorously applied.

Results
In patients with patellar fractures, the DVT incidence was 30.8%, with 1,790 clots identified in 1,021 diagnosed individuals, predominantly on the injured side (96.7%), and a minor portion on the uninjured side (3.2%). Key risk factors included older age (P<0.001, OR = 1.038), the presence of open injuries (P = 0.002, OR = 1.521), multiple injuries (P<0.001, OR = 3.623), and prolonged time from injury to surgical treatment (P<0.001, OR = 1.097). Conversely, higher levels of albumin (ALB) (P = 0.029, OR = 0.983) and sodium (Na) (P = 0.028, OR = 0.971) were identified as protective factors against DVT. Besides, ROC curve analysis revealed that the age of 52 years and a duration of 4 days from injury to surgery serve as predictive cut-off values for assessing the risk of DVT.

Conclusion
Our study investigates the incidence of thrombosis in patellar fracture patients and identifies key risk factors for DVT, including age, open and multiple injuries, and the time from injury to surgery. Additionally, we highlight sodium and albumin levels as protective factors. By establishing threshold values for age and surgical delay, our findings improve DVT risk assessment, facilitating earlier and more targeted interventions.
The effectiveness of online learning activities in a blended EAP course: relationships between language proficiency, online engagement, and language performance
Authors: Zhou Ying , Sheridan Simon , Zhang Qiwei 
Published: February 2025

Abstract
This study examines the effectiveness of the pre-seminar online learning activities in a blended English for Academic Purposes (EAP) course, with a particular focus on learner engagement with these online activities. It investigates the influence of learners’ English proficiency levels on their online engagement and examines the impact of this engagement on their language performance. A mixed-methods study design was employed, collecting quantitative data from 131 students and qualitative interview data from a subset of 18 participants drawn from this cohort. Simple linear regression results revealed that learners’ English proficiency levels did not predict their online behavioural engagement, but had a small predictive force on online cognitive engagement. Multiple regression results indicated a medium-sized impact of online engagement on EAP learners’ overall final scores. Specifically, simple regression results showed that online cognitive engagement was a significant predictor of learners’ EAP reading, listening, and writing scores, while behavioural engagement significantly predicted writing and speaking scores. Qualitative insights highlighted the importance of interactions between learner and content, learner and socialiser, and learner and interface when designing the online learning activities of a blended EAP course. The study concludes with an effective blended EAP learning model that optimises the use of technological modalities, emphasises the importance of online pedagogical, social, and technological interactions, and highlights the integration between online and onsite lessons.
Anti-obesity drugs alone or combined with exercise training in the management of obesity: a systematic review with meta-analysis
Authors: Marmett Bruna , da Silva Igor , Lira Fabio , Dorneles Gilson 
Published: February 2025

Abstract
Here we compare the efficacy of anti-obesity drugs alone or combined with exercise training on body weight and exercise capacity of obese patients. Randomized clinical trials that assessed the impact of any anti-obesity drug alone or combined with exercise training on body weight, body fat, fat-free mass and cardiorespiratory fitness in obese patients were retrieved from Pubmed and EMBASE up to May 2024. Risk of bias assessment was performed with RoB 2.0, and the GRADE approach assessed the certainty of evidence (CoE) of each main outcome. We included four publications summing up 202 patients. Two publications used orlistat as an anti-obesity drug treatment, while the other two adopted GLP-1 receptor agonist (liraglutide or tirzepatide) as a pharmacotherapy for weight management. Orlistat combined with exercise was superior to change body weight (mean difference (MD): −2.27 kg; 95 % CI: −2.86 to −1.69; CoE: very low), fat mass (MD: −2.89; 95 % CI: −3.87 to −1.91; CoE: very low), fat-free mass (MD: 0.56; 95 % CI: 0.40–0.72; CoE: very low), and VO2Peak (MD: 2.64; 95 % CI: 2.52–2.76; CoE: very low). GLP-1 receptor agonist drugs combined with exercise had a great effect on body weight (MD: −3.96 kg; 95 % CI: −5.07 to −2.85; CoE: low), fat mass (MD: −1.76; 95 % CI: −2.24 to −1.27; CoE: low), fat-free mass (MD: 0.50; 95 % CI: −0.98 to 1.98; CoE: very low) and VO2Peak (MD: 2.47; 95 % CI: 1.31–3.63; CoE: very low). The results reported here suggest that exercise training remains an important approach in weight management when combined with pharmacological treatment.
Access to Mental Health Care: Search Strategies for Identifying Mental Health Providers
Authors: Mong Michael , Lipscomb Thomas , Jeanfreau Michelle , Shelley Kyna S. , Wells Kevin , Paprzycki Peter 
Published: February 2025

Abstract
The present study examined search strategies that those in need of mental health services might use to select a provider. Specifically, 176 participants were recruited using Amazon Mechanical Turk and asked to imagine a scenario in which they had taken a job in a new city and had begun feeling isolated and depressed to the point that they decided to seek the services of a mental health provider. Participants responded to a survey that queried their likelihood of using various referral sources based on a five-category Likert-style response scale. An exploratory factor analysis yielded four main factors of potential referrals: promotional sources, nonmedical professional sources, traditional healthcare providers, and personal sources. These factors were then explored using multivariate analyses. The implications of these findings for providing pathways to greater access to mental health services as well as limitations of the study and future research directions are discussed.
Standardized methodology for calculating the cost of medical care funded by government sources
Authors: Sdvizhkova M. A. , Kovaleva S. A. , Fedyaev D. V. , Omelyanovskiy V. V. 
Published: February 2025

Background. Current challenges in healthcare include an increase in life expectancy and in medical care (MC) needs, thereby putting pressure on the limited resources of the Russian healthcare system. Efficient allocation of financial resources is becoming a priority. Calculating the cost of MC is considered as a key tool that affects the efficiency of the system. However, the existing calculation methods remain fragmented, which reduces their transparency and limits their application. The need for the unification of approaches to ensure standardization, improve the quality, and increase the accessibility of MC underscores the relevance of the present study.Objective: to develop a standardized methodology for calculating the cost of MC funded by government sources, aimed at enhancing transparency, standardizing calculations, and supporting a versatile approach in healthcare management.Material and methods. The study was based on the analysis of regulatory documentation for calculations in the public healthcare sector. The study methodology involved information search techniques, expert surveys, statistical data processing, and economic analysis.Results. The analysis of existing calculation methodologies revealed their fragmentation, disparities in the level of detail, methods for determining costs, and specific interpretations. The developed standardized methodology included the categorization of costs into direct and indirect, as well as the use of both normative and actual data. The cost of medical services and MC cases were considered the primary calculation units. The methodology was adapted to accommodate various funding sources and regional characteristics.Conclusion. The suggested methodology enhances the transparency, detail, and consistency of calculations, thereby facilitating effective management of resources within the healthcare system. Flexibility of the approaches allows for further adaptation to meet the needs of different stakeholders within the system.
Pharmacoeconomic analysis of netakimab in the treatment of ankylosing spondylitis: perspective of Russian healthcare system
Authors: Rudakova A. V. , Gaydukova I. Z. 
Published: February 2025

Objective: to evaluate clinical and economic effectiveness of netakimab therapy for ankylosing spondylitis (AS) in comparison with other biological disease-modifying antirheumatic drugs (bDMARDs) currently employed in clinical practice in the Russian Federation.Material and methods. The evaluation of clinical and economic effectiveness was carried out from the perspective of the healthcare system based on the results of a network meta-analysis of randomized clinical trials. Clinical effectiveness criteria included indicators of therapeutic response according to the Assessment of Spondyloarthritis International Society criteria, specifically ASAS20 and ASAS40, as well as by the Bath Ankylosing Spondylitis Disease Activity Index BASDAI50. A time horizon of the study was set at 2 years. Costs of pharmaceuticals were calculated according to the registered maximum retail prices, inclusive of value-added tax. In case of availability of biosimilars on the market, calculations were based on the minimum values of the registered prices.Results. According to the network meta-analysis, the efficacy of netakimab significantly surpassed that of other bDMARDs or demonstrated a trend towards higher efficacy for AS. The costs per patient achieving an additional response compared to standard therapy without bDMARDs when treated with netakimab appeared 31–77%, 34–80%, and 20–69% lower than those of other bDMARDs, according to ASAS20, ASAS40, and BASDAI50 criteria, respectively.Conclusion. Netakimab exhibits a higher clinical and economic effectiveness compared to other bDMARDs and may be considered as the preferred therapeutic option in comparable clinical scenarios for active AS, thereby ensuring cost-effectiveness for the healthcare system along with achieving the efficacy criteria compared to the standard treatment regimen. The limitations of the analysis determine the need for further research in this area.
Mapping 3D Sedimentary Structures with Joint Inversion of H/V Spectral Ratios and Multimode Dispersion Curves Derived from Ambient Noise—Application to the Xiong‘an New Area, China
Authors: Zhang Youyuan , Lu Laiyu , Maupin Valérie , Qin Tongwei , Ding Zhifeng 
Published: February 2025

ABSTRACT
We present a procedure to use ambient noise recordings to derive high-resolution 3D S-wave velocity models for sedimentary structures by joint inversion of phase velocity dispersion curves (DCs) and horizontal-to-vertical spectral ratios (HVSRs). This procedure is applied to seismological data from a network of 894 stations with a spacing of about 1 km located in the Xiong’an New Area (China), close to Beijing. To obtain the DCs, a Modified Correlation BeamForming method is used to process the noise at subarrays, which enables us to map directly the lateral variations of the phase velocity of the Rayleigh-wave fundamental mode, first overtone, as well as fundamental Love wave, in the total frequency range of 0.3–3 Hz. HVSRs are derived in the frequency range 0.1–10 Hz from the computation of the directional energy density of the three components at each station based on the diffuse field assumption. By combining the DCs obtained by the array-based method and the single-station HVSR curves in a joint inversion, a high-resolution 3D S-wave velocity model of the study area is established down to 2 km depth. The model brings useful information for seismic hazard assessment as well as geothermal energy exploration. It reveals that the thickness of the sediments is highly correlated with the distribution of geologic structures such as highs and lows.
Impact of environment and genetic factors on myopia in goan children: A behavioral perspective
Authors: Shetty Aksha , Ganguly Anasuya 
Published: February 2025

The interaction between lifestyle and family history of myopia plays a vital role in the development and progression of myopia. Understanding this interaction is essential to developing holistic treatment approaches.An environment-genetic score is a measure that combines information about a person's genetic predisposition and environmental factors that may contribute to the development of a specific condition. This score can help optometrists and other eye care professionals make more informed and personalised decisions regarding the management and treatment of myopia. A cross-sectional study was conducted in the ophthalmology outpatient department in Goa, India. Children aged between 7 and 15 years were included. Children with less than 0.1 logMAR visual acuity later underwent objective and subjective refraction. A prevalidated questionnaire was used to assess the environmental impact on myopia. Parental myopia was recorded. An Environmental Genetic Index (EGI) can be created to evaluate the risk of myopia in a given population. The difference between the prevalence of myopia in these families is defined as EGI. 152 children were evaluated, of which 64 (42.10%) were females. This study included 75 myopes (49.34%) and 77 emmetropes (50.66%). The prevalence of myopia in the myopic family was 85.71%; in the one-sided-myopic family, it was 60%; and in the non-myopic family, it was 45%. The environmental genetic index was 0.4071, suggesting that genetic factors may play a 40.71% role in the formation of myopia and environmental factors may play a 59.29% role in myopia development.Genetic factors may have played a 40.71% role in the formation of myopia in the studied population. 12.98% of Myopes lived in a flat, usually in a smaller house, without access to the garden compared to 1.33% of emmetropes. A statistically significant difference was seen in the distance near work was performed; myopes tend to hold their targets closer than 30 centimetres.
130 Years Since the Birth of Professor V.K. Modestov, the Founder of the First Medical Radiology Department
Authors: Mironov Sergey P. , Sergienko, Vladimir B. 
Published: February 2025

Vasily Kornilovich Modestov is an iconic figure of medical science. His achievements include the establishment of the resort destination in the Urals, the development of Russian balneology and radiobalneology, and a number of important inventions and proposals that preserved the health of many soldiers during the Great Patriotic War. However, even among radiologists, the role of V.K. Modestov as an organizer of the country's first Medical Radiology Department in the development of diagnostic and therapeutic use of open radioactive isotopes is little known. In an attempt to correct this injustice, the authors consider the origins of Medical Radiology Department, the main stages of its formation under the leadership of V.K. Modestov.
WITHDRAWN: Analysis of the difference between urban and rural areas in job satisfaction of primary health care workers
Authors: liu sicheng , Yang Ming , Sun Jiayi , Xu Yuan , Fang Guixia , Yang Jinxia 
Published: February 2025

Abstract

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
The Role of PR-5 Genes in Inducing Toxicity and Resistance in Potato Against Phytophthora infestans
Authors: Zaynab Madiha , Al-Yahyai Rashid , Sadder Monther , Mohamed Rania Ali El Hadi 
Published: February 2025

Abstract

The pathogenesis-related protein 5(PR-5) gene family plays a role in multiple biological processes within plants. To develop resistant potato varieties, it is crucial to understand the molecular defense mechanisms against Phytophthora infestans pathogen, particularly the pathogenesis-related (PR) gene family, specifically PR-5. In this study, we conducted a comprehensive analysis of the PR-5 gene family in potatoes at the genome-wide level and investigated their role during P. infestans infection by examining their expression patterns. By utilizing bioinformatics tools and high-throughput sequencing approaches, we successfully identified and confirmed the presence of the PR-5 gene family in the potato genome. Furthermore, phylogenetic analysis shed light on the evolutionary relationships among these genes, suggesting potential functional diversification. The RNA-seq data revealed increased expression of several PR-5 genes when the plants were infected with P. infestans, indicating their involvement in the plant's defense response against the pathogen. By identifying gene targets associated with late blight resistance, we have established a foundation for future research on plant-pathogen interactions and disease resistance in potatoes. This knowledge will facilitate the development of molecular breeding and genetic engineering strategies. Furtherore, our comprehensive genome-wide analysis and high-throughput expression profiling of the PR-5 gene family in potatoes have uncovered a novel mechanism for understanding plant defense at various levels. This research contributes to sustainable agriculture and the development of resistance to Phytophthora infestans in potatoes.
The Effects of GLUT9 and URAT1 Inhibitors on Cardiovascular Diseases: A Drug-Targeted Mendelian Randomization Study
Authors: Xu Qian , Liang Xinyu , Shi Wei , Zhang Huafeng 
Published: February 2025

Abstract

Objective The strong association between hyperuricemia and cardiovascular diseases prompts this study to investigate the effects of uric acid-lowering drugs, GLUT9 and URAT1 inhibitors (GLUT9i and URAT1i), on cardiovascular diseases using Mendelian randomization (MR) analyses.Methods In GWAS data, SNPs strongly associated with blood uric acid within 100kb regions around the GLUT9 and URAT1 genes are identified, serving as proxies for the targeted effects of genes on uric acid. Subsequently, these SNPs were utilized for MR analyses with gout, common cardiovascular diseases (heart failure, myocardial infarction, ischemic stroke, venous thromboembolism), and their risk factors (blood glucose, lipid levels, blood pressure). MR-Egger was employed for pleiotropy testing, and Cochran's Q test was utilized for heterogeneity testing to ensure the robustness of the MR analysis.Results Both URAT1i and GLUT9i are effective drugs for gout. URAT1i is associated with a reduced risk of heart failure (OR = 0.76, 95% CI 0.63, 0.92, P = 0.004), decreased diastolic blood pressure (β=-0.07, 95% CI -0.13, 0.00, P = 0.048), reduced high-density lipoprotein levels (β=-0.05, 95% CI -0.10, -0.01, P = 0.016), and increased fasting blood glucose levels (β = 0.07, 95% CI 0.02, 0.13, P = 0.006). Conversely, GLUT9i leads to reductions in fasting blood glucose (β =-0.03, 95% CI -0.05, -0.01, P = 0.013) and diastolic blood pressure (β =-0.03, 95% CI -0.05, -0.01, P = 0.005), and increases in high-density lipoprotein (β = 0.02, 95% CI 0.00, 0.03, P = 0.011)Conclusion For patients suffering from gout in conjunction with conditions like hyperglycemia, dyslipidemia, and hypertension, GLUT9i may represent a more promising therapeutic approach.
ALOX15-Mediated Neuron Ferroptosis Was Involved in Diabetic Peripheral Neuropathic Pain
Authors: Feng Zhiye , Lin Zhiqiang , Liu Jian , Chen Xi , Yan Wenxu , Li Fuye , Liu Zhongjie 
Published: February 2025

Abstract

Diabetic peripheral neuropathic pain (DPNP) is a prevalent complication among diabetic patients. Recent studies have confirmed that ferroptosis, an iron-dependent cell death driven by lipid peroxidation, plays a key role in DPNP development. However, biomarkers related to ferroptosis in DPNP remain undiscovered. Core genes related to DPNP were identified using bioinformatics. By assessing the mechanical paw withdrawal threshold (PWT) and thermal paw withdrawal latency (PWL), a mouse model of DPNP was established, along with a high-glucose-stimulated SH-SY5Y cell model. The combination of these two models allows for an in-depth investigation of the molecular biological mechanisms underlying DPNP. The viability and ferroptosis of these cells underwent evaluation via flow cytometry, CCK8 assays, Fe²⁺ assays, along with Western blotting. Differential expression analysis and random forest results identified Arachidonate 15-Lipoxygenase (ALOX15) as a core gene associated with DPNP-related ferroptosis. Subsequently, we verified elevated levels of iron death and ALOX15 expression in neurons using both in vivo and in vitro models. Notably, silencing ALOX15 markedly inhibited high glucose-induced ferroptosis within SH-SY5Y cells and restored neuronal viability. Our findings indicate that ALOX15 promotes the development of DPNP by mediating neuronal ferroptosis, providing new insights into the role of ALOX15 as a biomarker for DPNP while proposing innovative strategies to prevent and treat DPNP.
Exploring the Mediating Role of Theory of Planned Behavior (TPB) Components in Facilitating Health Behavior Change: A Comprehensive Conceptual Framework
Authors: Mat Isa Nurul Amyra , Misbah Nor Tasik , Mohd Fazi Fatin Athirah 
Published: February 2025

Health behavior, specifically physical health, is the main factor contributing to absenteeism and presenteeism of workers that affect an organization’s profitability. Based on the AIA Validity Survey report from 2017 until 2023, two main factors contributed to productivity loss: unhealthy diet and physical inactivity. As the banking sector strives to be sustainable and competitive, the employees need to improve their performance by increasing their commitment at work this situation has led to a more competitive environment for the banking sector, and the workers tend to experience fatigue as the work involves long working hours, inappropriate reward system, and lack of job autonomy; besides, the role conflict had increased tension, stress, and pressure due to the nature of heavy workload and the need of adaptation towards strict time limits. A study that is based on theory is more relevant to changing individual behavior. Thus, this study aims to identify the mediating role of the theory of planned behavior (TPB) component to understand the determinants related to HBCI among workers in the banking sector. This study will highlight the proposed framework that can be tested for future research in this study.