bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis
Authors: Barth Claudia , Kelly Sinead , Nerland Stener , Jahanshad Neda , Alloza Clara , Ambrogi Sonia , Andreassen Ole A. , Andreou Dimitrios , Arango Celso , Baeza Inmaculada , Banaj Nerisa , Bearden Carrie E. , Berk Michael , Bohman Hannes , Castro-Fornieles Josefina , Chye Yann , Crespo-Facorro Benedicto , de la Serna Elena , Díaz-Caneja Covadonga M. , Gurholt Tiril P. , Hegarty Catherine E. , James Anthony , Janssen Joost , Johannessen Cecilie , Jönsson Erik G. , Karlsgodt Katherine H. , Kochunov Peter , Lois Noemi G. , Lundberg Mathias , Myhre Anne M. , Pascual-Diaz Saül , Piras Fabrizio , Smelror Runar E. , Spalletta Gianfranco , Stokkan Therese S. , Sugranyes Gisela , Suo Chao , Thomopoulos Sophia I. , Tordesillas-Gutiérrez Diana , Vecchio Daniela , Wedervang-Resell Kirsten , Wortinger Laura A. , Thompson Paul M. , Agartz Ingrid 
Published: December 2022

AbstractEmerging evidence suggests brain white matter alterations in adolescents with early-onset psychosis (EOP; age of onset <18 years). However, as neuroimaging methods vary and sample sizes are modest, results remain inconclusive. Using harmonized data processing protocols and a mega-analytic approach, we compared white matter microstructure in EOP and healthy controls using diffusion tensor imaging (DTI). Our sample included 321 adolescents with EOP (median age = 16.6 years, interquartile range (IQR) = 2.14, 46.4% females) and 265 adolescent healthy controls (median age = 16.2 years, IQR = 2.43, 57.7% females) pooled from nine sites. All sites extracted mean fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) for 25 white matter regions of interest per participant. ComBat harmonization was performed for all DTI measures to adjust for scanner differences. Multiple linear regression models were fitted to investigate case-control differences and associations with clinical variables in regional DTI measures. We found widespread lower FA in EOP compared to healthy controls, with the largest effect sizes in the superior longitudinal fasciculus (Cohen’s d = 0.37), posterior corona radiata (d = 0.32), and superior fronto‐occipital fasciculus (d = 0.31). We also found widespread higher RD and more localized higher MD and AD. We detected significant effects of diagnostic subgroup, sex, and duration of illness, but not medication status. Using the largest EOP DTI sample to date, our findings suggest a profile of widespread white matter microstructure alterations in adolescents with EOP, most prominently in male individuals with early-onset schizophrenia and individuals with a shorter duration of illness.
Therapeutic sensitivity to standard treatments in BRCA positive metastatic castration-resistant prostate cancer patients—a systematic review and meta-analysis
Authors: Fazekas Tamás , Széles Ádám D. , Teutsch Brigitta , Csizmarik Anita , Vékony Bálint , Váradi Alex , Kói Tamás , Lang Zsolt , Ács Nándor , Kopa Zsolt , Hegyi Péter , Hadaschik Boris , Grünwald Viktor , Nyirády Péter , Szarvas Tibor 
Published: December 2022

Abstract
Background
Recent oncology guidelines recommend BRCA1/2 testing for a wide range of prostate cancer (PCa) patients. In addition, PARP inhibitors are available for mutation-positive metastatic castration-resistant PCa (mCRPC) patients following prior treatment with abiraterone, enzalutamide or docetaxel. However, the question of which of these standard treatments is the most effective for BRCA1/2 positive mCRPC patients remains to be answered. The aim of this meta-analysis was to assess the efficacy of abiraterone, enzalutamide and docetaxel in BRCA1/2 mutation-positive mCRPC patients in terms of PSA-response (PSA50), progression-free survival (PFS) and overall survival (OS).

Methods
As no interventional trials are available on this topic, we performed the data synthesis of BRCA1/2 positive mCRPC patients by using both proportional and individual patient data. For PSA50 evaluation, we pooled event rates with 95% confidence intervals (CI), while for time-to-event (PFS, OS) analyses we used individual patient data with random effect Cox regression calculations.

Results
Our meta-analysis included 16 eligible studies with 348 BRCA1/2 positive mCRPC patients. In the first treatment line, response rates for abiraterone, enzalutamide and docetaxel were 52% (CI: 25–79%), 64% (CI: 43–80%) and 55% (CI: 36–73%), respectively. Analyses of individual patient data revealed a PFS (HR: 0.47, CI: 0.26–0.83, p = 0.010) but no OS (HR: 1.41, CI: 0.82–2.42, p = 0.210) benefit for enzalutamide compared to abiraterone-treated patients.

Conclusions
Our PSA50 analyses revealed that all the three first-line treatments have therapeutic effect in BRCA1/2 positive mCRPC; although, based on the results of PSA50 and PFS analyses, BRCA positive mCRPC patients might better respond to enzalutamide treatment. However, molecular marker-driven interventional studies directly comparing these agents are crucial for providing higher-level evidence.
Integrating computational fluid dynamic, artificial intelligence techniques, and pore network modeling to predict relative permeability of gas condensate
Authors: Zeinedini Ehsan , Dabir Bahram , Dadvar Mitra 
Published: December 2022

AbstractThe formation of gas condensate near the wellbore affects the gas liquid two-phase flow between the pores. It may occur in the path between two pores depending on the thermodynamic conditions of the single-phase gas flow, two-phase gas liquid annular flow or the closed path of condensate in the throat. To model the behavior of gas condensate in a network of pores, relative permeability and naturally pressure drop should be calculated. This study obtained the flow characteristics (pressure drop) between the pores at different physical and geometric conditions using computational fluid dynamics (CFD). CFD is time-consuming, so its results were transferred to an artificial neural network (ANN) model and the ANN model was trained. The CFD was replaced with the ANN model for calculating the pressure drop. In addition, instead of utilizing empirical correlations to compute the accurate value of condensate formed in throats' corners at every time step, the flash calculation using Esmaeilzadeh–Roshanfekr equation of state was performed, and closed throats were specified. This accurately estimates gas and condensate distribution in the pore network. Furthermore, the value of condensate that transferred to the adjacent throats was computed using Poiseuille's law. The results showed that the proposed ANN-based proxy model could promote the calculation speed in gas condensate simulation, considering the dynamic change of relative permeability curves as a function of gas condensate saturation. Also, it was found that the relative permeability obtained by the proposed model is in good agreement with the experimental data. By entering the fractures pattern in the network model and predicting the relative permeability of gas and condensate by the proposed method, the role of fractures in gas condensate production in such reservoirs could be predicted. Dynamic changes due to the relative permeability of gas and condensate as a function of saturation can be entered into the reservoir simulation to optimize inertia and positive coupling phenomena to maximized condensate production in gas condensate reservoir.
Cognitive behavioral therapy for anxiety and depression in cancer survivors: a meta-analysis
Authors: Zhang Lemeng , Liu Xiaohong , Tong Fei , Zou Ran , Peng Wanglian , Yang Hui , Liu Feng , Yang Desong , Huang Xufen , Yi Lili , Wen Minni , Jiang Ling 
Published: December 2022

AbstractThis study aimed to investigate the effects of cognitive behavioral therapy (CBT) on anxiety and depression in cancer survivors. The PubMed, Embase, PsycINFO, and Cochrane Library databases were searched. Randomized controlled trials that evaluated the effects of CBT in cancer survivors were included. The standardized mean difference (SMD) was used as an effect size indicator. Fifteen studies were included. For the depression score, the pooled results of the random effects model were as follows: pre-treatment versus post-treatment, SMD (95% confidence interval [CI]) = 0.88 (0.46, 1.29),P < 0.001; pre-treatment versus 3-month follow-up, 0.83 (0.09, 1.76),P = 0.08; pre-treatment versus 6-month follow-up, 0.92 (0.27, 1.58),P = 0.006; and pre-treatment versus 12-month follow-up, 0.21 (− 0.28, 0.70),P = 0.40. For the anxiety score, the pooled results of the random effects model were as follows: pre-treatment versus post-treatment, 0.97 (0.58, 1.36),P < 0.001; pre-treatment versus 3-month follow-up, 1.45 (− 0.82, 3.72),P = 0.21; and pre-treatment versus 6-month follow-up, 1.00 (0.17, 1.83),P = 0.02). The pooled result of the fixed effects model for the comparison between pre-treatment and the 12-month follow-up was 0.10 (− 0.16, 0.35;P = 0.45). The subgroup analysis revealed that the geographical location, treatment time and treatment form were not sources of significant heterogeneity. CBT significantly improved the depression and anxiety scores of the cancer survivors; such improvement was maintained until the 6-month follow-up. These findings support recommendations for the use of CBT in survivors of cancer.
PSpice modeling of cervical and site-focused vagus nerve ultrasonic stimulation for reduced tumor necrosis factor-α production
Authors: Ghorayeb Sleiman R. , Hirsch Bryan 
Published: December 2022

AbstractClinical ultrasound is widely used as a diagnostic and therapeutic tool. Recently, it has been used to perform neuromodulation to treat diverse effects, including inflammation reduction through the vagus nerve. Although the mechanism by which ultrasound propagates through tissue for diagnostic purposes has been established, there is not a complete understanding of how it interacts with neurons to elicit excitation and inhibit inflammation. This work presents a novel technique based on a well-established electrical engineering tool, PSpice, to model cervical and site-focused vagus nerve ultrasonic stimulation to understand its capability in reducing tumor necrosis factor-α (TNF-α) production in the spleen. Transmission line theory is utilized as the basis for the different tissue layers. The models supported the hypothesis that site-focused stimulation has the advantage to decrease undesired efferent effects that would otherwise occur with cervical stimulation. Two different acoustic pressures, 0.25 and 0.83 MPa, were simulated for theoretical efficacy and safety based on previous experimental work conducted by others. The 0.25 MPa simulation was ideal for neurostimulation and reduction of TNF-α, while 0.83 MPa resulted in much higher intensity levels that will most likely induce additional inflammation.
On the impact of carbohydrate-binding modules (CBMs) in lytic polysaccharide monooxygenases (LPMOs)
Authors: Forsberg Zarah , Courtade Gaston 
Published: December 2022

Abstract
Lytic polysaccharide monooxygenases (LPMOs) have revolutionized our understanding of how enzymes degrade insoluble polysaccharides. Compared with the substantial knowledge developed on the structure and mode of action of the catalytic LPMO domains, the (multi)modularity of LPMOs has received less attention. The presence of other domains, in particular carbohydrate-binding modules (CBMs), tethered to LPMOs has profound implications for the catalytic performance of the full-length enzymes. In the last few years, studies on LPMO modularity have led to advancements in elucidating how CBMs, other domains, and linker regions influence LPMO structure and function. This mini review summarizes recent literature, with particular focus on comparative truncation studies, to provide an overview of the diversity in LPMO modularity and the functional implications of this diversity.
Outcome of Surgical Treatment for Metastatic Spinal Cord Compression: A Single-Center Retrospective Study
Authors: Hashmi Syed Muhammad Maroof , Hammoud Ibrahim , Kumar Pranaw , Sartaj Afaq Ali , Ghosh Kaushik , Ray Arupratan , Golash Aprajay 
Published: December 2022

Abstract
Objective The spinal column is one of the most prevalent regions for metastasis, with an increasing frequency of spinal metastases. Spinal cord metastatic tumor damages the vertebral body, weakens the spinal support, and exerts mass effect on the spinal cord. Overzealous surgical intervention does not provide any additional benefit in most of the spinal metastasis due to shorter life expectancy. The principal goal of this study is to analyze the outcome of various surgical treatments offered to patients with metastatic spinal cord compression (MSCC).
Methods Retrospective cohort study including all patients that underwent surgical intervention for MSCC from March 2013 to March 2020.
Results A total of 198 patients were included, 113 males and 85 females; the mean age was 62 years. The most common primary cancer was prostate (21.71%) followed by hematological (20.07%) and lung (16.66%). At 6-month postsurgery, 68.68% of patients were Frankel grade D or E (vs. 23.23% preoperatively), 16.6% were grade C (vs 57% preoperatively), and 14.64% were grade A or B (vs. 19.69% preoperatively). Pain on numeric rating scale was decreased from 6.38 ± 3.08 to 3.39 ± 0.73 at 24 hours postsurgery and 1.94 ± 0.67 at 6 months.
Conclusion This study found that the majority of patients, undergoing minimally invasive spinal stabilization and decompression for metastatic spinal tumors, have better quality of life, analgesia, and mobility. In conclusion, treatment for spinal metastases should be individualized and a multidisciplinary approach is needed.
Higher derivative gravity’s anti-Newtonian limit and the Caldirola–Kanai oscillator
Authors: Niedermaier M 
Published: December 2022

Abstract
Fourth order gravity in

1
+
d

dimensions is investigated in its anti-Newtonian limit where lightcones shrink to lines. The limiting theory is fourth order in time derivatives, still fully diffeomorphism invariant, and retains the original number of physical degrees of freedom. In an unimodular Hamiltonian formulation the dynamics can, however, be reduced to a second order one by regarding the unimodular metric as a composite field. In a gauge where the logarithm of the volume element is ‘time’ a Hamiltonian proper arises, which (for each spatial point) is a matrix generalization of a Caldirola–Kanai oscillator with inverted quartic potential. In an alternative ‘Wick-flipped’ Hamiltonian formulation an analogous reduced system arises with non-inverted quartic potential.
Current status and new insights about the capacitively coupled electronegative plasma source: injection of energetic beam-like electrons to electrode
Authors: Makabe Toshiaki 
Published: December 2022

Abstract
High-frequency capacitively coupled plasmas (HF-CCPs) have been widely investigated physically, electrically, optically, and numerically. Such research has focused on the sustaining mechanism and the interaction of the ion sheath with the material surface. Most of the reactive feed gas molecules produce a pair consisting of a negative ion and a neutral by the dissociative electron attachment. The low-temperature electronegative plasma with high electronegativity has an interesting and specific sustaining mechanism caused by the negative ions in HF-CCPs. One of the functions is a production of high energy electrons in front of the instantaneous anode under the presence of a static double layer with field reversal. Current understanding of electronegative plasmas has been advanced through the knowledge about the fundamental collision, transport processes, and related effects of negative ion and long-lived neutral on the plasma structure and function. We present new insights into the injection of energetic beam-like electrons to a biased wafer in a pulsed two-frequency mode in electronegative HF-CCP, based on a series of our previous works in CF4/Ar. Here, the criteria, consisting of plasma internal and external parameters, for the injection provide the design rule for a charging free plasma process. The magnitude of the electronegativity as a key parameter to inject negative charges is elucidated in the bulk plasma as a function of gas density times electrode distance in HF-CCP in O2 as an example. Both sides of the electronegativity correspond to the different types of the transport and the sustainability of the bulk plasma.
A review of advances in image-guided orthopedic surgery
Authors: Fan Xingqi , Zhu Qiyang , Tu Puxun , Joskowicz Leo , Chen Xiaojun 
Published: December 2022

Abstract
Orthopedic surgery remains technically demanding due to the complex anatomical structures and cumbersome surgical procedures. The introduction of image-guided orthopedic surgery (IGOS) has significantly decreased the surgical risk and improved the operation results. This review focuses on the application of recent advances in artificial intelligence (AI), deep learning (DL), augmented reality (AR) and robotics in image-guided spine surgery, joint arthroplasty, fracture reduction and bone tumor resection. For the pre-operative stage, key technologies of AI and DL based medical image segmentation, 3D visualization and surgical planning procedures are systematically reviewed. For the intra-operative stage, the development of novel image registration, surgical tool calibration and real-time navigation are reviewed. Furthermore, the combination of the surgical navigation system with AR and robotic technology is also discussed. Finally, the current issues and prospects of the IGOS system are discussed, with the goal of establishing a reference and providing guidance for surgeons, engineers, and researchers involved in the research and development of this area.
Quantum speed limit time: role of coherence
Authors: Paulson K G , Banerjee Subhashish 
Published: December 2022

Abstract
The minimum evolution time between multi-qubit quantum states is estimated for non-Markovian quantum channels. We consider the maximally coherent pure and mixed states as well as multi-qubit X states as initial states and discuss the impact of initial coherence and the behaviour of coherence on their speed of evolution for both dephasing and dissipative processes. The role of the non-zero value of initial coherence under information backflow conditions for the non-unital dissipative process is revealed by the flow of quantum speed limit time (τ

QSL
). The trade-off between mixedness and coherence on the speed limit time reveals the nature of the quantum process the states undergo. The complementarity effect between mixedness and coherence is more prominent in the quantum non-unital dissipation process. The parametric trajectory of speed limit time vividly depicts the difference in the evolution of pure and mixed initial states, and this could be used to distinguish between the unital and non-unital channels studied in this work. Our investigation of quantum speed limit time on multi-qubit entangled X states reveals that τ

QSL
can be identified as a potential dynamical witness to distinguish multi-qubit states in the course of evolution.
Increasing secondary metabolites production of Phyllanthus sp to support development of herbal medicine industry
Authors: Utami N , Bidara I S , Royani J I , Reninta R , Dwimahyani I , Mulyono D 
Published: December 2022

Abstract
This study aim to improve the quality of Phyllanthus sp production by increasing the content of secondary metabolites as a bioactive compound. Phyllanthus sp contains various secondary metabolites that enhance immunity and treat diabetes, hypertension, antioxidants, anti-cancer, kidney disorders, and other illnesses. Since the Covid-19 pandemic, Phyllanthus sp widely used as a raw material for making herbal medicines. The trade value of Indonesian herbal medicines is estimated to increase in 2022, and the price will reach around the US $ 910 million, so it has very bright business prospects. These relatively limited phytopharmaceutical products constrain the supply of high-quality raw materials under the requirements of the herb medicine industry. Therefore, conducting a depth assessment related to efforts to improve the quality of Phyllanthus sp production by increasing the content of secondary metabolites is necessary. The efforts to enhance the quality of Phyllanthus sp as a source of herbal medicine raw materials can be made through plant breeding such as genetic mutations and in combination with the environmental arrangements of soil water content and solar radiation intensity. The efforts to increase the quality of herbal medicine raw materials are critical to support the development of the herbal medicine industry.
Role of institutions to improve farmer’s resilience in facing climate change
Authors: Barokatuminalloh  , Widayaningsih N , Setiarso O 
Published: December 2022

Abstract
When exposed to climate change, farmers will get vulnerable and sensitive due to their low adaptation capacity. The latter can in fact be increased through institutional strengthening, as strong institutions will enable farmers to have an opportunity to succeed by improving their performance. This study examines the institutional form of farmer self-organisation and resources access in Banyumas Regency. The target population is comprised of farmers affected by climate change. This study uses SWOT to analyse farmers’ self-organisation. The results showed that by strengthening farmers’ self-organisation, young farmers become aware that agriculture should be taken as the main livelihood and that they have social capital and resources to increase their farming capacity. Farmers’ weaknesses stem from their low level of education and family income. The opportunities of farmers could be gained from having a network to strengthen their farming business and easy access to production factors. Nevertheless, farmers are also threatened by a number of factors—i.e., the absence of norms in the community to regulate land and water use as well as local wisdom to support farming, existing institutions in the community that do not support farming optimally, and the average production per hectare that is still below the national average production. The policy implication is that farmers must increase their capacity and build strong institutions to increase their resilience in facing the climate change.
Diet Quality and Risk of Older-onset Crohn’s Disease and Ulcerative Colitis
Authors: Khalili Hamed , Hakansson Niclas , Casey Kevin , Lopes Emily , Ludvigsson Jonas F , Chan Andrew T , Chan Simon S M , Olen Ola , Wolk Alicja 
Published: December 2022

Abstract

Background
We aimed to assess the relationship between diet quality and risk of older-onset Crohn’s disease [CD] and ulcerative colitis [UC].

Methods
We conducted a prospective cohort study of 83 147 participants from the Swedish Mammography Cohort and the Cohort of Swedish Men. We used food frequency questionnaires to calculate adherence scores to multiple derived healthy diet patterns: Alternate Healthy Eating Index [AHEI], Healthy Eating Index-2015 [HEI-2015], Healthful Plant-Based Diet Index [HPDI], and modified Mediterranean Diet Score [mMED] at baseline in 1997 in both cohorts. Diagnoses of CD and UC were retrieved from the Swedish Patient Register. We used Cox proportional hazards modelling to estimate the adjusted hazard ratios [HRs] and 95% confidence intervals [CIs].

Results
Through December of 2017, we confirmed 164 incident cases of CD and 395 incident cases of UC. Comparing the highest with the lowest quartiles, the adjusted HRs of CD were 0.73 [95% CI, 0.48, 1.12, ptrend = 0.123] for AHEI; 0.90 [0.57, 1.41, ptrend = 0.736] for HEI 2015; 0.52 [95% CI 0.32, 0.85, ptrend = 0.011] for HPDI; and 0.58 [95% CI 0.32, 1.06, ptrend = 0.044] for mMED. In contrast, we did not observe an association between any diet quality score and risk of UC.

Conclusions
We found that several healthy eating patterns were associated with a lower risk of older-onset CD. Our findings provide a rationale for adapting different healthy dietary patterns based on individuals’ food preferences and traditions in designing future prevention strategies for IBD.