bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in Image Quality after Three Laser Keratorefractive Procedures for Myopia
Authors: Sarkar Samrat , Devi Preetirupa , Vaddavalli Pravin Krishna , Reddy Jagadesh C. , Bharadwaj Shrikant R. 
Published: January 2022

SIGNIFICANCE
Psychophysical estimates of spatial and depth vision have been shown to be better after bilateral ReLEx small-incision lenticule extraction (SMILE) refractive surgery for myopia, relative to photorefractive keratectomy (PRK) and femtosecond laser-assisted in situ keratomileusis (FS-LASIK). The present study provides the optical basis for these findings using computational image quality analysis.

PURPOSE
This study aimed to compare longitudinal changes in higher-order wavefront aberrations and image quality before and after bilateral PRK, FS-LASIK, and SMILE refractive procedures for correcting myopia.

METHODS
Wavefront aberrations and image quality of both the eyes of 106 subjects (n = 40 for FS-LASIK and SMILE and n = 26 for PRK) were determined pre-operatively and at 1-week, 1-month, 3-month, and 6-month post-operative intervals using computational through-focus analysis for a 6-mm pupil diameter. Image quality was quantified in terms of its peak value and its interocular difference, residual defocus that was needed to achieve peak image quality (best focus), and the depth of focus.

RESULTS
The increase in root mean squared deviations of higher-order aberrations post-operatively was lesser after SMILE (1-month visit median [25th to 75th interquartile range], 0.34 μm (0.28 to 0.39 μm]) than after PRK (0.80 μm [0.74 to 0.87 μm]) and FS-LASIK (0.74 μm [0.59 to 0.83 μm]; P ≤ .001), all relative to pre-operative values (0.20 μm [0.15 to 0.30 μm]). The peak image quality dropped and its interocular difference increased, best focus shifted myopically by 0.5 to 0.75 D, and depth of focus widened significantly after PRK and FS-LASIK surgeries, all relative to pre-operative values (P < .001). All these changes were negligible but statistically significant in a minority of instances after SMILE surgery (P ≥ .01).

CONCLUSIONS
Although all three refractive surgeries correct myopia, the image quality and its similarity between eyes are better and closer to pre-operative values after SMILE, compared with FS-LASIK and PRK. These results can be explained from the underlying increase in higher-order wavefront aberrations experienced by the eye post-operatively.
Mapping the allosteric effects that define functional activity of SARS-CoV-2 specific antibodies
Authors: Tulsian Nikhil K. , Raghuvamsi Palur V. , Qian Xinlei , Yue Gu , D/O Shunmuganathan Bhuvaneshwari , Samsudin Firdaus , Hwa Wong Yee , Jianqing Lin , Purushotorman Kiren , Kozma Mary M. , Wang Bei , Lescar Julien , Wang Cheng-I , Anand Ganesh S. , Bond Peter J. , MacAry Paul A. 
Published: January 2022

AbstractPrevious studies on the structural relationship between human antibodies and SARS-CoV-2 have focused on generating static snapshots of antibody complexes with the Spike trimer. However, antibody-antigen interactions are dynamic, with significant binding-induced allosteric effects on conformations of antibody and its target antigen. In this study, we employ hydrogen-deuterium exchange mass spectrometry, in vitro assays, and molecular dynamics simulations to investigate the allosteric perturbations linked to binding events between a group of human antibodies with differential functional activities, and the Spike trimer from SARS-CoV-2. Our investigations have revealed key dynamic features that define weakly or moderately neutralizing antibodies versus those with strong neutralizing activity. These results provide mechanistic insights into the functional modes of human antibodies against COVID-19, and provide a rationale for effective antiviral strategies.TeaserDifferent neutralizing antibodies induce site-specific allosteric effects across SARS-CoV-2 Spike protein
Perceived Timing of Cutaneous Vibration and Intracortical Microstimulation of Human Somatosensory Cortex
Authors: Christie Breanne , Osborn Luke E. , McMullen David P. , Pawar Ambarish S. , Thomas Tessy M. , Bensmaia Sliman J. , Celnik Pablo A. , Fifer Matthew S. , Tenore Francesco V. 
Published: January 2022

AbstractBackgroundElectrically stimulating the somatosensory cortex can partially restore the sense of touch. Though this technique bypasses much of the neuroaxis, prior studies with non-human primates have found that conscious detection of touch elicited by intracortical microstimulation (ICMS) lags behind the detection of vibration applied to the skin. These findings may have been influenced by a mismatch in stimulus intensity; typically, vibration is perceived as more intense than ICMS, which can significantly impact temporal perception.ObjectiveThe goal of this study was to evaluate the relative latency at which intensity-matched vibration and ICMS are perceived in a human subject.MethodsA human participant implanted with microelectrode arrays in somatosensory cortex performed a reaction time task and a temporal order judgment (TOJ) task. In the reaction time task, the participant was presented with vibration or ICMS and verbal response times were obtained. In the TOJ task, the participant was sequentially presented with a pair of stimuli – vibration followed by ICMS or vice versa – and reported which stimulus occurred first.ResultsWhen vibration and ICMS were matched in intensity at a “high” stimulus level, the reaction time to vibration was 48 ms faster than ICMS. When both stimuli were perceived as lower in intensity, the difference in reaction time was even larger: vibration was perceived 90 ms before ICMS. However, in the TOJ task, vibratory and ICMS sensations arose at comparable latencies, with points of subjective simultaneity that were not significantly different from zero.ConclusionsBecause the perception of ICMS is slower than that of intensity-matched vibration, it may be necessary to stimulate at stronger ICMS intensities (thus decreasing reaction time) when incorporating ICMS sensory feedback into neural prostheses.
The Effect of Weather Pattern on the Second Wave of Coronavirus: A cross study between cold and tropical climates of France, Italy, Colombia, and Brazil
Authors: Islam Ahmed 
Published: January 2022

AbstractThis study aims to explore and understand the common belief that COVID infection rate is highly dependent on either the outside temperature and/or the humidity. Thirty-six regions/states from two humid-tropical countries, namely Brazil and Colombia and two countries with temperate climate, France and Italy, are studied over the period of October to December. Daily outside temperature, relative humidity and hospitalization/cases are analyzed using Spearman’s correlation. The eighteen cold regions of France and Italy has seen an average drop in temperature from 10°C to 6°C and 17°C to 7°C, respectively, and France recorded an addition of 2.3 million cases, while Italy recorded an addition of 1.8 million cases. Outside temperature did not fluctuate much in tropical countries, but Brazil and Colombia added 4.17 million and 1.1 million cases, respectively. Köppen–Geiger classification showed the differences in weather pattern between the four countries, and the analysis showed that there is very weak correlation between either outside weather and/or relative humidity alone to the COVID-19 pandemic.
Design, immunogenicity, and efficacy of a pan-sarbecovirus dendritic-cell targeting vaccine
Authors: Coléon Séverin , Wiedemann Aurélie , Surénaud Mathieu , Lacabaratz Christine , Hue Sophie , Prague Mélanie , Cervantes-Gonzalez Minerva , Wang Zhiqing , Ellis Jerome , Sansoni Amandine , Pierini Camille , Bardin Quentin , Fabregue Manon , Sharkaoui Sarah , Hoest Philippe , Dupaty Léa , Picard Florence , Centlivre Mireille , Ghosn Jade ,   French COVID Cohort Study Group, Thiébaut Rodolphe , Cardinaud Sylvain , Malissen Bernard , Zurawski Gérard , Zarubica Ana , Zurawski Sandra M , Godot Véronique , Lévy Yves 
Published: January 2022

AbstractThe emergence of SARS-CoV-2 variants of concern (VOCs) that escape pre-existing antibody neutralizing responses increases the need for vaccines that target conserved epitopes and induce cross-reactive B- and T-cell responses. We used a computational approach and sequence alignment analysis to design a new-generation subunit vaccine targeting conserved sarbecovirus B- and T-cell epitopes from Spike (S) and Nucleocapsid (N) to antigen-presenting cells expressing CD40 (CD40.CoV2). We demonstrate the potency of CD40.CoV2 to elicit high levels of cross-neutralizing antibodies against SARS-CoV-2, VOCs, and SARS-CoV-1 in K18-hACE2 transgenic mice, associated with improved viral control and survival after challenge. In addition, we demonstrate the potency of CD40.CoV2 in vitro to recall human multi-epitope, functional, and cytotoxic SARS-CoV-2 S- and N-specific T-cell responses that are unaffected by VOC mutations and cross-reactive with SARS-CoV-1 and, to a lesser extent, MERS epitopes. Overall, these findings provide a framework for a pan-sarbecovirus vaccine.
Leveraging global multi-ancestry meta-analysis in the study of Idiopathic Pulmonary Fibrosis genetics
Authors: Partanen Juulia J. , Häppölä Paavo , Zhou Wei , Lehisto Arto Aleksanteri , Ainola Mari , Sutinen Eva , Allen Richard J , Stockwell Amy D , Oldham Justin M , Guillen-Guio Beatriz , Flores Carlos , Noth Imre , Yaspan Brian L , Jenkins R. Gisli , Wain Louise V , Ripatti Samuli , Pirinen Matti ,   Global Biobank Meta-analysis Initiative (GBMI), Kaarteenaho Riitta , Myllärniemi Marjukka , Daly Mark J , Koskela Jukka T. 
Published: January 2022

AbstractThe research of rare and devastating orphan diseases such as Idiopathic Pulmonary Fibrosis (IPF) has been limited by the rarity of the disease itself. The prognosis is poor – the prevalence of IPF is only ∼4-times the incidence of the condition, limiting the recruitment of patients to trials and studies of the underlying biology of the disease. However, global biobanking efforts can dramatically alter the future of IPF research.Here we describe the largest meta-analysis of IPF, with 8,492 patients and 1,355,819 population controls from 13 biobanks around the globe. Finally, we combine the meta-analysis with the largest available meta-analysis of IPF so far, reaching 11,160 patients and 1,364,410 population controls in analysis.We identify seven novel genome-wide significant loci, only one of which would have been identified if the analysis had been limited to European ancestry individuals. We observe notable pleiotropy across IPF susceptibility and severe COVID-19 infection, beyond what is known to date. We also note a significant unexplained sex-heterogeneity effect at the strongest IPF locus MUC5B.
Long-lasting cellular immunity to SARS-CoV-2 following infection or vaccination and implications for booster strategies
Authors: Mazzoni Alessio , Vanni Anna , Spinicci Michele , Lamacchia Giulia , Kiros Seble Tekle , Rocca Arianna , Capone Manuela , Di Lauria Nicoletta , Salvati Lorenzo , Carnasciali Alberto , Mantengoli Elisabetta , Farahvachi Parham , Zammarchi Lorenzo , Lagi Filippo , Colao Maria Grazia , Liotta Francesco , Cosmi Lorenzo , Maggi Laura , Bartoloni Alessandro , Rossolini Gian Maria , Annunziato Francesco 
Published: January 2022

AbstractImmunization against SARS-CoV-2, the causative agent of coronavirus disease-19 (COVID-19) occurs via natural infection or vaccination. However, it is currently unknown how long infection- or vaccination-induced immunological memory will last. We performed a longitudinal evaluation of immunological memory to SARS-CoV-2 following mRNA vaccination in naïve and COVID-19 recovered individuals. We found that cellular immunity is still detectable 8 months after vaccination, while antibody levels decline significantly especially in naïve subjects. We also found that a booster injection is more efficacious in reactivating immunological memory to spike protein in naïve than in previously SARS-CoV-2 infected subjects. Finally, we observed a similar kinetics of decay of humoral and cellular immunity to SARS-CoV-2 up to one year following natural infection in a cohort of unvaccinated individuals. Short-term persistence of humoral immunity may account for reinfections and breakthrough infections, although long-lived memory B and CD4+ T cells may protect from severe disease. A booster dose restores optimal anti-spike immunity in naïve subjects, while the need for vaccinated COVID-19 recovered subjects has yet to be defined.
A cohort study of the effect of SARS-CoV-2 point of care rapid RT-PCR at the Emergency Department on targeted admission
Authors: Mortazavi Susanne E , Inghammar Malin , Christiansen Claus , Pesola Anne-Katrine , Stenkilsson Mikael , Paulsson Magnus 
Published: January 2022

(ii)AbstractBackgroundTo prevent nosocomial transmission of SARS-CoV-2, infection control measures are implemented for patients with symptoms compatible with COVID-19 until reliable test results are available. This delay targeted admission to the most appropriate ward based on the medical condition. SARS-CoV-2 rapid antigen detection (RAD) tests and point of care (POC) rapid RT-PCR were introduced at emergency departments (EDs) in late 2020, but the consequence on targeted admission is unknown.ObjectivesTo assess the effect of RAD tests and POC rapid RT-PCR (VitaPCR, Credo Diagnostics, Singapore) on targeted admission.MethodsPatients presenting at the ED of a referral hospital (N = 2,940) between 13-Nov-2020 and 12-Jan-2021 were included. The study period was delimited by introduction of RAD tests and VitaPCR. Participant data was collected retrospectively, and outcome variables were length-of-stay (LoS), intrahospital transfers and targeted admission to COVID-19 ward.ResultsRAD tests reduced ED LoS for participants with positive tests or that were not tested. Negative VitaPCR results reduced mean hospital LoS by 1.5 (95%CI: 0.3–2.7) days and admissions to COVID-19 wards from 34.5 (95%CI: 28.9-40.5) to 14.7 (95%CI: 11.1-19.1) per 100 admissions. Introduction of VitaPCR reduced transfers between hospital wards in the first 5 days from 50.0 (95%CI: 45.0-55.0) to 34.0 (95%CI: 30.3-37.9) per 100 admissions.ConclusionRAD tests enabled rapid detection of SARS-CoV-2 infection which had pronounced effects on LoS at the ED. VitaPCR added the possibility of exclusion of the infection which increased targeted admissions, reduced intrahospital transfers and lead to shorter stay at the hospital.
COVID-19 vaccine effectiveness among immunocompromised populations: a targeted literature review of real-world studies
Authors: Di Fusco Manuela , Lin Jay , Vaghela Shailja , Lingohr-Smith Melissa , Nguyen Jennifer L , Sforzolini Thomas Scassellati , Judy Jennifer , Cane Alejandro , Moran Mary M 
Published: January 2022

AbstractIntroductionFrom July through October of 2021, several countries issued recommendations for increased COVID-19 vaccine protection for individuals with one or more immunocompromised (IC) conditions. It is critically important to understand the vaccine effectiveness (VE) of COVID-19 vaccines among IC populations as recommendations are updated over time in response to the evolving COVID-19 pandemic.Areas coveredA targeted literature review was conducted to identify real-world studies that assessed COVID-19 VE in IC populations between December 2020 and September 2021. A total of 10 studies from four countries were identified and summarized in this review.Expert opinion/commentaryVE of the widely available COVID-19 vaccines, including BNT162b2 (Pfizer/BioNTech), mRNA-1273 (Moderna), Ad26.COV2.S (Janssen), and ChAdOx1 nCoV-19 (Oxford/AstraZeneca), ranged from 64%-90% against SARS-CoV-2 infection, 73%-84% against symptomatic illness, 70%-100% against severe illness, and 63%-100% against COVID-19-related hospitalization among the fully vaccinated IC populations included in the studies. COVID-19 VE for most outcomes in the IC populations included in these studies was lower than in the general populations. These findings provide preliminary evidence that the IC population requires greater protective measures to prevent COVID-19 infection and associated illness, hence should be prioritized while implementing recommendations of additional COVID-19 vaccine doses.
Comparison of outcomes from COVID infection in pediatric and adult patients before and after the emergence of Omicron
Authors: Wang Lindsey , Berger Nathan A. , Kaelber David C. , Davis Pamela B. , Volkow Nora D. , Xu Rong 
Published: January 2022

AbstractBackgroundThe Omicron SARS-CoV-2 variant is rapidly spreading in the US since December 2021 and is more contagious than earlier variants. Currently, data on the severity of the disease caused by the Omicron variant compared with the Delta variant is limited. Here we compared 3-day risks of emergency department (ED) visit, hospitalization, intensive care unit (ICU) admission, and mechanical ventilation in patients who were first infected during a time period when the Omicron variant was emerging to those in patients who were first infected when the Delta variant was predominant.MethodThis is a retrospective cohort study of electronic health record (EHR) data of 577,938 first-time SARS-CoV-2 infected patients from a multicenter, nationwide database in the US during 9/1/2021–12/24/2021, including 14,054 who had their first infection during the 12/15/2021–12/24/2021 period when the Omicron variant emerged (“Emergent Omicron cohort”) and 563,884 who had their first infection during the 9/1/2021–12/15/2021 period when the Delta variant was predominant (“Delta cohort”). After propensity-score matching the cohorts, the 3-day risks of four outcomes (ED visit, hospitalization, ICU admission, and mechanical ventilation) were compared. Risk ratios, and 95% confidence intervals (CI) were calculated.ResultsOf 14,054 patients in the Emergent Omicron cohort (average age, 36.4 ± 24.3 years), 27.7% were pediatric patients (<18 years old), 55.4% female, 1.8% Asian, 17.1% Black, 4.8% Hispanic, and 57.3% White. The Emergent Omicron cohort differed significantly from the Delta cohort in demographics, comorbidities, and socio-economic determinants of health. After propensity-score matching for demographics, socio-economic determinants of health, comorbidities, medications and vaccination status, the 3-day risks in the Emergent Omicron cohort outcomes were consistently less than half those in the Delta cohort: ED visit: 4.55% vs. 15.22% (risk ratio or RR: 0.30, 95% CI: 0.28-0.33); hospitalization: 1.75% vs. 3.95% (RR: 0.44, 95% CI: 0.38-0.52]); ICU admission: 0.26% vs. 0.78% (RR: 0.33, 95% CI:0.23-0.48); mechanical ventilation: 0.07% vs. 0.43% (RR: 0.16, 95% CI: 0.08-0.32). In children under 5 years old, the overall risks of ED visits and hospitalization in the Emergent Omicron cohort were 3.89% and 0.96% respectively, significantly lower than 21.01% and 2.65% in the matched Delta cohort (RR for ED visit: 0.19, 95% CI: 0.14-0.25; RR for hospitalization: 0.36, 95% CI: 0.19-0.68). Similar trends were observed for other pediatric age groups (5-11, 12-17 years), adults (18-64 years) and older adults (≥ 65 years).ConclusionsFirst time SARS-CoV-2 infections occurring at a time when the Omicron variant was rapidly spreading were associated with significantly less severe outcomes than first-time infections when the Delta variant predominated.
Performance on verbal fluency tasks depends on the given category/letter: Preliminary data from a multivariable analysis
Authors: Gabrić Petar , Vandek Mija 
Published: January 2022

AbstractVerbal fluency tasks are often used in neuropsychological research and may have predictive and diagnostic utility in psychiatry and neurology. However, researchers using verbal fluency have uncritically assumed that there are no category-or phoneme-specific effects on verbal fluency performance. We recruited 16 healthy young adult subjects and administered two semantic (animals, trees) and phonemic (K, M) fluency tasks. Because of the small sample size, results should be regarded as preliminary and exploratory. On the animal compared to the tree task, subjects produced significantly more legal words, had a significantly lower intrusion rate, significantly shorter first-response latencies and final silence periods, as well as significantly shorter between-cluster response latencies. These differences may be explained by differences in the category sizes, integrity of the categories’ borders, and efficiency of the functional connectivity between subcategories. On the K compared to the M task, subjects produced significantly more legal words and had significantly shorter between-cluster response times. Counterintuitively, a corpus analysis revealed there are more words starting with ⟨m⟩ compared to ⟨k⟩ in the experimental language. Our results potentially have important implications for research utilizing verbal fluency, including decreased reproducibility, questionable reliability of diagnostic and predictive tools based on verbal fluency, decreased knowledge accumulation, and increased number of publications with potentially misleading clinical interpretations.
Baptism of fire: Modeling the effects of prescribed fire on tick-borne disease
Authors: Guo Emily , Agusto Folashade B. 
Published: January 2022

AbstractRecently, tick-borne illnesses have been trending upward and are an increasing source of risk to people’s health in the United States. This is due to range expansion in tick habitats as a result of climate change. Thus, it is imperative to find a practical and cost-efficient way of managing tick populations. Prescribed burns are a common form of land management that can be cost efficient if properly managed and can be applied across large amounts of land. In this study, we present a compartmental model for ticks carrying Lyme disease and uniquely incorporate the effects of prescribed fire using an impulsive system to investigate the effects of prescribed fire intensity (high and low) and the duration between burns. Our study found that fire intensity has a larger impact in reducing tick population than the frequency between burns. Furthermore, burning at high intensity is preferable to burning at low intensity whenever possible, although high intensity burns may be unrealistic due to environmental factors. Annual burns resulted in the most significant reduction of infectious nymphs, which are the primary carriers of Lyme disease.
How To Enhance Empathy Nursing Students In Education: Literature Review
Authors: Permana Bhakti , Pandin Moses Glorino Rumambo 
Published: January 2022

AbstractIntroductionThe tendency of reducing student empathy requires efforts to improve it through education or training. The purpose of this review is to identify education, learning, or teaching that is used to increase student empathy.MethodThe design used a Literature Systematic Review. Articles were conducted in three electronic databases guided by The PRISMA. Articles published in English and in 2019 to 2021.ResultsThe result obtained 20 articles and will be reviewed. Eighteen articles show an effect or relationship between intervention and empathy. Training materials that can increase student empathy are the concept of empathy, communication, mindfulness, and transcultural nursing education. Education and training using patients/patient simulations to help improve student empathy, namely: expert patients, ECARE Program, polypharmacy effects; clinical Simulation of Inpatients, Lectures in class, Virtual Dementia Tour, living in poverty, and games for team interaction. Another method is through the KSS module, mannequin simulator experience, and peers.ConclusionEducation and training on the concepts of empathy, communication, meditation, and cultural competence using Simulation and immersion methods with patients, being like patients, using mannequins, or interacting with vulnerable groups can increase student empathy. Faculty and lecturers can apply experiential learning methods with Simulation and immersion in learning or training courses.