bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategies for improving mental health and wellbeing used by adults ageing with HIV: a qualitative exploration
Authors: Mwangala Patrick N. , Wagner Ryan G. , Newton Charles R. , Abubakar Amina 
Published: August 2022

Background: Physical and mental health problems are common among older adults living with HIV (OALWH). Adaptive coping strategies play a vital role in improving these adults' mental health and well-being despite the deleterious effects of HIV and ageing. However, in sub-Saharan Africa, limited evidence exists on the commonly utilized coping strategies in this population. We explore the coping strategies used by Kenyan OALWH to improve their mental health and wellbeing. Methods: Semi-structured in-depth interviews were conducted between October and December 2019 with 56 participants: 34 OALWH (53% female), 11 healthcare providers (63% female) and 11 primary caregivers (73% female) in Kilifi County. All interviews were audio-recorded and transcribed verbatim. We used the framework approach to synthesize the qualitative data. Results: Five major themes emerged from the analysis of participants’ narratives, including self-care practices, religion and spirituality, relational living (social connectedness), generativity, identity, and mastery. Our study further revealed maladaptive coping strategies, including reliance on over-the-counter medications, self-isolation, waiting to see if symptoms would subside despite doing nothing, and HIV treatment interruptions during prolonged periods of prayer and fasting. Conclusions: Our findings provide an initial understanding of the coping strategies used by OALWH to confront HIV and ageing challenges in a low-literacy, low socio-economic Kenyan setting. Our results suggest that interventions designed to enhance personal capacity, social support, positive religiosity and spirituality, and intergenerational connections may be beneficial in improving the mental health and well-being of OALWH.
Genetic diversity of eight maize (Zea mays) cultivars from East Nusa Tenggara (Indonesia) based on inter simple sequence repeat markers
Authors: YANI AHMAD , CHASANI ABDUL RAZAQ , DARYONO BUDI SETIADI 
Published: August 2022

Abstract. Yani A, Chasani AR, Daryono BS. 2022. Genetic diversity of eight maize Zea mays L. cultivars from East Nusa Tenggara based on inter simple sequence repeat markers. Biodiversitas 23: 4124-4130. East Nusa Tenggara (NTT) is one of Indonesia's island that has many local maize cultivars. However, the existence of this local corn is threatened by the presence of high-yielding maize seeds. Therefore, characterization of local maize cultivars using molecular marker is needed to conserve the germplasm. This study aims to determine the genetic diversity of local maize cultivars (Zea maysL.) from East Nusa Tenggara based on ISSR markers. This research used eight local maize cultivars (Watar Ohaq, Watar Puluq, Wata Bura, Wata Kuma, Wata Bunga, Pena Muti, Boti Pulut, and Latun Wara). Young leaves of maize were used for DNA isolation. Total genomic DNA was isolated using Genomic DNA Mini Kit for Plant (Geneaid). DNA was then amplified using 5 ISSR molecular markers (ISSR-807, ISSR-808, UBC-809, UBC-811, UBC-834). DNA band profiles were scored based on the presence or absence of bands. Genetic variability was analyzed based on the UPGMA method using the MVSP ver application. 3.1. Local maize from NTT has high genetic diversity (similarity index between 0.29-0.65). Local maize cultivars were separated into two main clusters at a similarity index of 0.43 and the grouping pattern was not influenced by the geographic location of
local maize origin.
On Terms: What's in a Name? Intellectual Disability and “Condition,” “Disorder,” “Syndrome,” “Disease,” and “Disability”
Authors: Thurm Audrey , Srivastava Siddharth 
Published: August 2022

Abstract
Individuals living with intellectual disability can have multiple co-occurring medical conditions including associated genetic diagnoses. The number of genetic etiologies associated with ID is growing, with some quite new and rare, and others more common and associated with what is often considered a syndrome. In the context of genetic etiologies and associated medical comorbidities, appropriate use of descriptive terminology warrants clarification. Using accurate nomenclature is essential for descriptions, especially as terms are used across both research and clinical reports. Here we discuss several terms that may be confused with each other, including “condition,” “disorder,” “syndrome,” “disease,” and “disability.” Our goal is to shed light on the meanings of the five descriptors and their appropriate use in the ID population, especially in relation to those who have a genetic diagnosis.
Improving Social and Play Outcomes for Students With Significant Disabilities During Recess
Authors: Amadi Chelsea J. , Brock Matthew E. , Barczak Mary A. , Anderson Eric J. 
Published: August 2022

Abstract
For students with autism, recess is often a missed opportunity to develop social competence and relationships. Although interventions have been developed to promote interactions and social skills for students with average or above-average intellectual functioning, there has been less focus on students with autism who have below-average intellectual functioning or who meet the criteria for intellectual disability. In this single-case design study, we tested the efficacy of a combined peer-mediated and social skills instruction intervention on the interactions, play, and social skills of three students with autism who met their state's criteria for alternate assessment for students with significant cognitive disabilities. Social skills instruction featured video models that portrayed same-aged peers demonstrating individualized social skills on the playground. For all three students, there were substantial increases in interactions, play and social skills, and students and their peers provided positive feedback about the intervention.
Preliminary study on a novel dedicated plate for iliac fractures in dogs
Authors: Moi Tryssia S. M. , Minto Bruno W. , Macedo Ana P. , Lucena Dayvid V. F. , Malta Caio A. S. , Dias Luis G. G. G. 
Published: August 2022

Introduction
The aim of this study was to describe and evaluate a novel plate designed specifically for the canine ilium using finite element methods. The cranial portion of the plate had an elliptical shape and contained nine screw holes. The caudal portion of the plate was triangular with three screw holes. Four and three screws were used at the cranial (screw 1 to 4) and caudal (screw 5 to 7) segment of the plate. Finite element models of the plate and canine pelvis were created. A load of 300 N was applied on the femur-hip joint contact area. Values of Von Mises Stress on the plate, screws and the maximum and minimum main stresses in the bone were used to capture the mechanical factors in this study.

Results
The novel implant had a plate stress of 51.9 megapascals (MPa) with higher stress in the dorsal part of the plate. Screws 2 and 4 showed similar stress values of 17.3 MPa. Screws 1 and 3 were the most loaded (51.9 MPa and 75 MPa, respectively). Screws 5, 6, and 7 showed similar dissipation and stress values (21.55 MPa). There was traction force in the dorsal region of the pubis and compression in the ventral part, with dissipation and values of 15.4 MPa and 23.9 MPa, respectively, acquiring balance between them.

Conclusion
The novel plate is potentially applicable and specifically suitable for iliac fractures in dogs. The screws distribution modeled proved itself strategical since the simulated stresses were evenly distributed throughout the implant construct.
Evaluating fomite risk of brown paper bags storing personal protective equipment exposed to SARS-CoV-2: A quasi-experimental study
Authors: Unger Kyirsty , Dietz Leslie , Horve Patrick , Van Den Wymelenberg Kevin , Lin Amber , Kinney Erin , Kea Bory 
Published: August 2022

Introduction
Literature is lacking on the safety of storing contaminated PPE in paper bags for reuse, potentially increasing exposure to frontline healthcare workers (HCW) and patients. The aim of this study is to evaluate the effectiveness of paper bags as a barrier for fomite transmission of SARS-CoV-2 by storing face masks, respirators, and face shields.

Methods
This quasi-experimental study evaluated the presence of SARS-CoV-2 on the interior and exterior surfaces of paper bags containing PPE that had aerosolized exposures in clinical and simulated settings. Between May and October 2020, 30 unique PPE items were collected from COVID-19 units at two urban hospitals. Exposed PPE, worn by either an infected patient or HCW during a SARS-CoV-2 aerosolizing event, were placed into an unused paper bag. Samples were tested at 30-minute and 12-hour intervals.

Results
A total of 177 swabs were processed from 30 PPE samples. We found a 6.8% positivity rate among all samples across both collection sites. Highest positivity rates were associated with ventilator disconnection and exposure to respiratory droplets from coughing. Positivity rates differed between hospital units. Total positivity rates were similar between 30-minute (6.7%) and 12-hour (6.9%) sample testing time intervals. Control samples exposed to inactivated SARS-CoV-2 droplets had higher total viral counts than samples exposed to nebulized aerosols.

Conclusions
Data suggests paper bags are not a significant fomite risk for SARS-CoV-2 transmission. However, controls demonstrated a risk with droplet exposure. Data can inform guidelines for storing and re-using PPE in situations of limited supplies during future pandemics.
Association between non-acute traumatic injury (TI) and heart rate variability (HRV) in adults: A systematic review protocol
Authors: Maqsood Rabeea , Khattab Ahmed , Bennett Alexander N. , Boos Christopher J. 
Published: August 2022

Heart Rate Variability (HRV) is an indirect measure of autonomic function. Attenuated HRV is linked to worsening health outcomes including Major Adverse Cardiovascular Events (MACE). The relationship between traumatic injury (TI) and HRV has been limitedly studied. This research protocol has been designed to conduct a systematic review of the existing evidence on the association between non-acute TI and HRV in adults. Four electronic bibliographic databases (Web of Science, CINAHL, Medline, and Scopus) will be searched. The studies on non-acute (>7 days post injury) TI and HRV in adults will be included, followed by title-abstract screening by two reviewers independently. The quality and risk of bias of the included studies will be assessed using Axis and a six-item Risk of Bias Assessment tool for of Non-randomized Studies (RoBANS) respectively. Grading of Recommendations Assessment, Development and Evaluation (GRADE) will assess the quality of evidence. The extracted data will be synthesized using narrative syntheses and a Forest plot with or without meta-analysis- whichever permitted by the pooled data. This will be the first systematic review to examine the relationship between generalized TI and HRV in adults.
Trial registration: (PROPSERO registration number: CRD: CRD42021298530) https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021298530.
Fibroblast growth factor 23: translating analytical improvement into clinical effectiveness for tertiary prevention in chronic kidney disease
Authors: Ferraro Simona , Biganzoli Giacomo , Calcaterra Valeria , Zuccotti Gianvincenzo , Biganzoli Elia Mario , Plebani Mario 
Published: August 2022

Abstract

Objectives
Fibroblast growth factor 23 (FGF23) plays a key role in the pathophysiology of chronic kidney disease (CKD) and of the associated cardiovascular diseases, ranking on the crossroads of several evolving areas with a relevant impact on the health-care system (ageing, treatment of CKD and prevention from cardiovascular and renal events). In this review, we will critically appraise the overall issues concerning the clinical usefulness of FGF23 determination in CKD, focusing on the analytical performances of the methods, aiming to assess whether and how the clinical introduction of FGF23 may promote cost-effective health care policies in these patients.

Content
Our comprehensive critical appraisal of the literature revealed that we are currently unable to establish the clinical usefulness of FGF23 measured by ELISA in CKD, as stability issues and suboptimal analytical performances are the major responsible for the release of misleading results. The meta-analytical approach has failed to report unambiguous evidence in face of the wide heterogeneity of the results from single studies.

Summary and Outlook
Our review has largely demonstrated that the clinical usefulness depends on a thorough analytical validation of the assay. The recent introduction of chemiluminescent intact-FGF23 (iFGF23) assays licensed for clinical use, after passing a robust analytical validation, has allowed the actual assessment of preliminary risk thresholds for cardiovascular and renal events and is promising to capture the iFGF23 clinically relevant changes as a result of a therapeutic modulation. In this perspective, the analytical optimization of FGF23 determination may allow a marriage between physiology and epidemiology and a merging towards clinical outcomes.
Should Start-Ups Be Green? Corporate Environmental Responsibility, Institutional Contexts, and Financial Performance of New Ventures
Authors: Zhang Hui , Song Di , Chen Ying 
Published: August 2022

Abstract
Should new ventures with limited resources invest in corporate environmental responsibility (CER)? Considering the significance of entrepreneurship’s considerable social and economic influences, this question is critical for both researchers and practitioners. Drawing on signaling theory, we argue that CER is an effective strategy for new ventures to overcome the liability of newness by shaping accountability and professionalism perceived by stakeholders, which in turn enhances their financial performance. Furthermore, this positive impact is reinforced by new ventures’ corporate political activity, whereas institutional pressure weakens such an impact. Using a nationally representative sample of 2,147 Chinese new ventures, these hypotheses are largely found supported. This research makes important theoretical contributions to the entrepreneurship literature by shedding new light on how new ventures overcome the liability of newness, and also extends the environmental management literature by providing a novel and entrepreneurship-based explanation regarding the performance implications of CER.
Potential role of endoplasmic reticulum stress in the pathophysiology of polycystic ovary syndrome
Authors: Alexandre-Santos Beatriz , Martins Felipe Figuerôa Tassinari Rocha , da Silva Gonçalves Larissa , de Oliveira Guimarães Clara , Carla-Ruggiero Fernanda , Magliano D’Angelo Carlo 
Published: August 2022

Abstract
Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects million women worldwide, presenting a complex pathophysiology that has not been fully elucidated yet. Recently, it has been suggested that PCOS triggers the endoplasmic reticulum (ER) stress, thus being associated with unfolded protein response (UPR) activation. Indeed, the UPR response has been associated with several pathological conditions, including in the reproductive system. Several studies demonstrated that ovarian UPR markers are upregulated in PCOS, being associated with worst ovarian outcomes, and this was ameliorated by ER stress inhibition. In this review, we aim to summarize the main findings from previous studies covering this topic, in an attempt to clarify the potential role of ER stress and the UPR response in the pathophysiology of PCOS.
A study on deep reinforcement learning-based crane scheduling model for uncertainty tasks
Authors: Feng Kai , Yang Lingzhi , He Dongfeng , Lin Shijing , Su Buxin 
Published: August 2022

Abstract
Aiming at the crane scheduling problem for uncertainty tasks in multi-crane scheduling situation, this article proposes a deep reinforcement learning-based crane scheduling modeling method that is not dependent on mathematical planning and has certain generality. First, the crane scheduling process is integrated into deep reinforcement learning framework in which the orbit space of the crane and the transportation task is environmental information and crane is the intelligent agent. Second, the interactive mode between reinforcement learning algorithm and environment is adjusted to adapt to the combined learning of multi-crane scheduling model. Last, the crane scheduling model for uncertainty tasks is constructed by optimizing reward discount factor, learning rate, and reward function intensive mode. Testing of the model is carried out based on practical crane scheduling in one steelmaking workshop. Scheduling proposal is generated and all crane tasks are completed within the planned time, which verifies the feasibility of this model. Results show that compared with manual scheduling plan, the scheduling proposal based on the new model reduces total task completion time by 11.52%, time of collision of crane routes decreases by 57.14%, and negative crane transportation distance shortens by 55.26%. The high efficiency of the scheduling model is therefore verified.
Anti-inflammatory effect of polyherbal composition with hepatoprotective and choleretic properties on LPS-stimulated murine macrophages
Authors: Gahramanova Malahat , Ostapchuk Andriy , Molozhava Olga , Svyatetska Vitalina , Rudyk Mariia , Hurmach Yevheniia , Gorbach Oleksandr , Skivka Larysa 
Published: August 2022

Abstract

Objectives
A polyherbal formulation with hepatoprotective and choleretic properties combining pharmacological potential of eight medicinal plants was developed in Nargiz Medical center (Republic of Azerbaijan) for the use as herbal tea. To explore the effect of polyherbal composition on the metabolism of LPS-stimulated macrophages in vitro.

Methods
The qualitative and quantitative phytochemical analysis was conducted using specific color reactions and gas chromatography-mass spectrometry (GC–MS). Nitric oxide (NO) assay was determined using the Griess reaction. Reactive oxygen species (ROS) generation was measured using ROS-sensitive fluorescence indicator, H2DCFDA, by flow cytometry. Arginase activity was examined by colorimetric method.

Results
The studied polyherbal formulation exerted anti-inflammatory activity in LPS-stimulated macrophages which was evidenced by dose-dependent decrease of ROS generation and by shift of arginine metabolism to the increase of arginase activity and decrease of NO release.

Conclusions
Our findings suggest that the herbal tea reduces macrophage inflammatory activity, that provide an important rationale to utilize it for the attenuation of chronic inflammation typical of hepatobiliary disorders.
Free representations of outer automorphism groups of free products via characteristic abelian coverings
Authors: Marchand Alexis 
Published: August 2022

Abstract
Given a free product 𝐺, we investigate the existence of faithful free representations of the outer automorphism group

Out
⁡

(
G
)

\operatorname{Out}(G)

, or in other words of embeddings of

Out
⁡

(
G
)

\operatorname{Out}(G)

into

Out
⁡

(

F
m

)

\operatorname{Out}(F_{m})

for some 𝑚.
This is based on work of Bridson and Vogtmann in which they construct embeddings of

Out
⁡

(

F
n

)

\operatorname{Out}(F_{n})

into

Out
⁡

(

F
m

)

\operatorname{Out}(F_{m})

for some values of 𝑛 and 𝑚 by interpreting

Out
⁡

(

F
n

)

\operatorname{Out}(F_{n})

as the group of homotopy equivalences of a graph 𝑋 of genus 𝑛, and by lifting homotopy equivalences of 𝑋 to a characteristic abelian cover of genus 𝑚.
Our construction for a free product 𝐺, using a presentation of

Out
⁡

(
G
)

\operatorname{Out}(G)

due to Fuchs-Rabinovich, is written as an algebraic proof, but it is directly inspired by Bridson and Vogtmann’s topological method and can be interpreted as lifting homotopy equivalences of a graph of groups.
For instance, we obtain a faithful free representation of

Out
⁡

(
G
)

\operatorname{Out}(G)

when

G
=

F
d

∗

G

d
+
1

∗
⋯
∗

G
n

G=F_{d}\ast G_{d+1}\ast\cdots\ast G_{n}

, with

F
d

F_{d}

free of rank 𝑑 and

G
i

G_{i}

finite abelian of order coprime to

n
-
1

n-1

.
Safety assessment and management of spent nuclear fuel for TRIGA mark II research reactor
Authors: Heritier Beya , Mahmoud Rowayda F. , El Saghir Ahmed , Shaat Mohamed K. , Badawi Alya 
Published: August 2022

Abstract
Democratic Republic of Congo (DRC) has a TRIGA mark II research reactor called TRICO II, its design power is 1.00 MW. The reactor was in extended shutdown state since November 2004. The DRC government has decided to resume its operation using the last uploaded core. One of the safety features to be determined before putting the spent fuel into the reactor core is the calculation of its excess reactivity, radionuclide inventories as well as its discharge burn-up. The spent fuel was modeled and simulated by using Monte Carlo software, MCNPX code. The input data and the horizontal and vertical modeling for the fuel pins, control rods and moderator were done. The model results were validated by calculating the effective delayed neutron fraction (β
eff) and the worth of the control rods. The results of the criticality and fuel burn-up were compared with the reference design parameters and with the experimental measurements and it were found in good agreement. The calculations showed that the last uploaded core has 47.00 g of 235U which represent only 2% of fissile materials. The depletion analysis results showed that the highest radio-activities come from 151Sm, 137Cs, 90Y, 90Sr and 85Kr.
Endothelial cell-specific molecule 1 (ESM1) promoted by transcription factor SPI1 acts as an oncogene to modulate the malignant phenotype of endometrial cancer
Authors: He Yu , Lin Lu , Ou Yurong , Hu Xiaowen , Xu Chi , Wang Caizhi 
Published: August 2022

Abstract
We aimed to study the function and mechanism of endothelial cell-specific molecule 1 (ESM1) in endometrial cancer (EC). The binding relationship between SPI1 and ESM1 was predicted by bioinformatics analysis and verified by the dual-luciferase reporter assay. The expressions and effects of SPI1 and ESM1 were determined using quantitative real-time PCR, immunohistochemistry, Western blot, and functional experiments. ESM1 was highly expressed in EC and was associated with the poor prognosis of patients. ESM1 silencing suppressed the viability, proliferation, invasion, and angiogenesis of EC cells, down-regulated expressions of PCNA, N-cadherin, Vimentin, VEGFR-1, VEGFR2, and EGFR, but upregulated E-cadherin level, while ESM1 overexpression did oppositely. Moreover, SPI1 bound to ESM1. Overexpressed SPI1 promoted the expression of ESM1 and induced malignant phenotype (viability, proliferation, and invasion), which were countervailed by ESM1 silencing. Collectively, ESM1 induced by SPI1 promotes the malignant phenotype of EC.