bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Effective Channel Allocation Designed Using Hmdic Algorithm in Distributed Manet
Authors: R Suganya , D Ranjani , R Kanmani 
Published: July 2022

Abstract
The mobile ad hoc networks (MANET), the channel availability problem reaches a greater extent and it gains lot of attention in communication network. Increasing mobile usage can cause deficiency for channel allocation so that the improved channel allocation scheme is proposed to solve the availability problem. In this paper, the distributed dynamic channel allocation model is designed using hybrid memory dragonfly with imperialist competitive (HMDIC) algorithm. This technique allocates the channel to mobile hosts based on optimization logic. Without the base station infrastructure, the MANET creates a distributed network within the coverage area. In this scenario, the HMDIC optimizer technique randomly initiates their individual node to update and store its pbest value using memory dragonfly using satellite images. Then the constraint values are deployed to compute the cost function which in terms a powerful imperialist of global optimal solution is obtained at the end. In this way, the channels are allocated in efficient manner. In order to validate the performance, HMDIC based distributed dynamic channel allocation (DDCA) scheme provide promising result of assigning the available channels thereby improving the channel reuse efficiency and fractional interference.
New AMH cutoff values for warning of decreased ovarian response based on MCL characteristics in young women: a retrospective study using a propensity score-matching analysis
Authors: Lv Jia-Bei , Han Ying , Wang Xin-Yan , Yuan Li-Na , Diao Jun-Rong , Fan Ya-Zhen , Luo Hai-Ning 
Published: July 2022

Abstract
Background: Menstrual cycle length (MCL) and ovarian response varies widely among women of childbearing age, we tried to provide AMH cutoffs for "normal" and "weakened" ovarian responses to them, which give an early warning of the onset of decreased ovarian response.Methods This was a retrospective study in women aged 21 to 35 years with MCLs of 21-35 days receiving in vitro fertilization (IVF) treatment at our hospital from October 2018 to October 2021. Intergroup variables were balanced using propensity score matching, and each case patient was matched with three control patients. A receiver operating characteristic curve was used to calculate the AMH cutoff values.Results We included 135 patients with MCLs of 21-25 days and 405 matched control patients with MCLs of 26-35 days who received IVF treatment. The case group had significantly fewer retrieved oocytes, lower AMH values and higher initial and total Gn levels during controlled ovarian hyperstimulation than the control group. The ovarian response began to decrease when AMH was < 3.5 ng/ml in the case group and < 2.7 ng/ml in the control group.Conclusion In young women with MCLs of 21-35 days, short MCL was negatively correlated with AMH values and the number of oocytes retrieved. In patients with MCLs of 21-25 days and 26-35 days, the AMH cutoff values corresponding to the onset of decreased ovarian response were 3.5 ng/ml and 2.7 ng/ml, respectively.
Determination of the timing of Bevacizumab administration in Osimertinib and Bevacizumab combination therapy
Authors: Teng Fei , Xu Ziyi , Hao Xuezhi , Yang Ke , Qiao Yingkai , Wang Qi , Wang Jing , Li Junling , Xing Puyuan 
Published: July 2022

Abstract
Background: In recent years, studies have suggested that EGFR-TKIs can act synergistically with vascular endothelial growth factor inhibitors. In osimertinib and bevacizumab combinatorial treatment, the timing for the addition of bevacizumab is yet to be clearly defined. Methods: From April 1, 2018, to January 1, 2021, a total of 31 patients were enrolled in this study. Osimertinib was orally administered once every day at a dose of 80 mg. There was a treatment cycle every 21 days. Bevacizumab (7.5 mg/kg) was administered by drip infusion on the first day of each cycle. Results: 31 patients included in this study.The median progression-free survival were 13.47 months (range: 7.72–19.21 months), respectively. A total of 26 patients were subjected to response analysis. Of the 26 patients, 6 (23.08%) had a partial response, 20 (72.92%) had stable disease, and none had progressive disease. The overall response rate was 23.07%. Sixteen patients had central nervous system (CNS) disease. The CNS response rate in patients with measurable and non-measurable diseases was 71%. All patients were evaluated for the toxic effects of the drugs. The average use of bevacizumab was 9.13 months (range: 3.5–13.03 months). The treatment modality of “T to A+T” was found to yield better benefits to the patients than the treatment modality of “A+T” (HR=0.165, 95% CI: 0.029–0.928, P=0.041). EGFR21 had a significantly higher risk of progression than EGFR19 (HR=6.998, 95% CI: 2.101–23.311, P=0.002). Conclusion: The treatment modality of “T to A+T” was found to be better than that of “A+T” and can prolong the time of drug resistance. Patients with EGFR19 had a better prognosis than those with EGFR21, regardless of the treatment modality.
Cancer Regulator EGFR‑ErbB4 Heterodimer is Stabilized Through Glycans at the Dimeric Interface
Authors: Motamedi Zahra , Shahsavari Mehri , Rajabi-Maham Hassan , Irani Maryam Azimzadeh 
Published: July 2022

Abstract
The ErbB family of tyrosine kinase receptors is composed of four homologous members, including EGFR (ErbB1/HER1), ErbB2 (HER2), ErbB3 (HER3), and ErbB4 (HER4). Since the ErbB proteins play vital roles in various developmental processes, their mutation or overexpression leads to severe abnormalities such as cancer. The general mechanism of ErbB receptors activity is binding to growth factors via their extracellular domain followed by tyrosine phosphorylation intracellularly. Yet the EGFR and ErbB4 are the only two members that keep their ligand-binding domain and the tyrosine kinase activated. In contrast, ErbB2 and ErbB3 are incapable of keeping their ligand-binding and kinase domains activated, respectively. Active ErbB receptors form homo and heterodimers by binding of two similar or different family members together, respectively. Ligands and intracellular pathways that could be activated through heterodimerization are more diverse compared to homodimers. Moreover, it is known that N-glycosylation is critical for stabilizing and activating the ErbB receptors. In this study, atomistic molecular dynamics simulations were used on one of the most potentiated ErbB heterodimers (EGFR-ErbB4) in the glycosylated and unglycosylated states. It was shown that the EGFR-ErbB4 heterodimer is highly stabilized by glycosylation. The increased stability is most significant at the dimeric interfaces. Regulated by packing of three glycans attached to EGFR (Asn337) and ErbB4 (Asn333, Asn523) at the dimeric interface. Finally, it is proposed that heterodimerization is the persistent key player of the ErbB receptors activation. Thus, targeting the heterodimers in future therapeutic designs could be a promising approach against drug resistance ErbB positive cancers.
Surface Irrigation Potential Assessment Using GIS and HBV Model: A Case Study at Fetam Watershed, Upper Blue Nile, Ethiopia
Authors: Desalegn Hunegnaw , Damtew Banchiamlak , Mulu Arega 
Published: July 2022

Abstract
Small-scale rainfed small-holder farming accounts for about 85% of Ethiopia's food supply. As a result, the increase in crop production does not correspond to the increase in the country's population. As a result, in order to alleviate this problem, irrigation must be used to supplement rainfall farming. It is critical to do this assessment of potential water resources and suitable terrain for irrigation in every section of the country. As a result, this study began to assess the Fetam watershed's irrigate and land resource potential for irrigation development. Irrigation suitability problems like as slope, soil type, land usage land cover, and distances as a water source are used in justification to designate potentially irrigable earth. Data from several government agencies was obtained and utilized, including hydrological, meteorological, Digital elevation model, soil drainage, soil depth, soil texture, and agro-climatic map data. In addition, satellite pictures were utilized in this study. Irrigation appropriateness was assessed using a geographic information system with multi-criteria decision evaluations, and the HBV and CROPWAT 8 models were utilized to determine the likelihood of water resources and irrigation water requirements. The coefficient of determination (R2), Nash Sutcliffe models efficiency (NSE), and Percent Biases (PBIAS) of the performance evaluation statistics were 0.54, 0.51, + 15 and 0.69, 0.67, -15, respectively, indicating that the HBV model performance is satisfactory. In general, there are 12583.47 ha of appropriate lands used for irrigation inside research areas.
Increase in grain protein and gluten contents of bread wheat by the introgression of a T. timopheevii segment into chromosome 2A
Authors: Shchukina L.V. , Simonov A.V. , Demenkova M.A. , Klykov A.G. , Shamanin V.P. , Pozherukova V.E. , Lepekhov S.B. , Chebatareva M.V. , Petin V.A. , Börner A. , Pshenichnikova Tatyana Alexeevna 
Published: July 2022

Abstract
End use and value of harvested bread wheat grain is determined by its protein and gluten content. Therefore, the stable manifestation of this trait in a cultivar is an important breeding goal. According to some reports, the tetraploid species T. timopheevii is characteristic for a high protein and gluten contents in grain. However, there are no examples of transfer of genes for these traits from this species. The aim of this study was to transfer chromosome 2A with an introgression from T. timopheevii from an experimental line (line 821) to bread wheat cultivar Saratovskaya 29 (S29) and to show its association with increased protein and gluten contents in grain. The chromosome 2A with introgression from T. timopheevii was transferred to cv. S29 using a monosomic line and its integrity was checked using 14 molecular markers. The obtained single chromosome substitution line S29 (821 2A) was grown in 5 different geographical locations: Novosibirsk, Omsk, Barnaul, Ussuriysk and Gatersleben, as well as in a greenhouse. It was found that under all conditions, protein and gluten contents in grain of line S29 (821 2A) was significantly higher by 1–2% and 3–4%, respectively, compared to the parental cultivar. In most cases this introgression did not reduce grain yield and retained thousand grain weight. The line had high rheological properties of dough comparable to the high-quality cv. S29. It has been suggested that the new genetic factor may belong to the homoeoallelic series of gene Gpc-2 for high grain protein content.
Simultaneous Cr (VI) reduction and Diazinon oxidation with organometallic sludge formation under UV irradiation: Kinetics, degradation pathways and mechanism
Authors: Karimi Pouria , Azarpira Hossein , Rasolevandi Tayebeh , Sarkhosh Maryam , Azizi Shohreh , Mohseni Seyed Mohsen , Sadani Mohsen 
Published: July 2022

Abstract
In this study, simultaneous removal of an organic matter (Diazinon -DIZ) and a inorganic substance (Chromium-Cr) was used. Broken down of organic matter by UV irradiation and produces various radicals, including sulfides, carboxyl, hydroxyl, hydrated electrons, and various organic radicals that are highly reactive and help us to precipitation inorganic substance (Cr). The optimal condition was 30:1 DIZ: Cr Molar ratio, pH 9, about 100% and 82.3% of DIZ and Cr were obtained in 30 minutes. Cr deposition was very slow at first. After the destruction of the DIZ structure, Cr deposition began and various types of sludge with disturbed properties were formed. These sledges were analyzed by Ftir analysis and showed green sludge could be Chromium (III) Hydroxide, brown sludge due to Chromium (III) Hydroxide, Tiny green crystals from Chromium (III) oxide, red brick from Chromium (II) acetate Chromium trioxide or as well as Black sludge caused by Chromium oxide were identified. in UV/DIZ/Cr process, k obs, r obs, range obtained 0.33 − 0.15, 16.8–23.4 $ with the both Cr and DIZ concentration increased from 50 to 150 mg L− 1. Also, E EO for Cr precipitation were 24.65 to 5.74 and for DIZ 12.54 to 4.73 (kwh m− 3). Depending on the amount of energy consumption, TCS were 37.19 to 10.47 for Cr precipitation and 4.46 to 1.25 $. It is important to note that when both pollutants are exposed to ultraviolet light, more energy and cost are generally required from UV/DIZ process and less than of UV/Cr process. But it should be noted that in fact 50 mg L− 1 of chromium and 50 mg L− 1 of DIZ are being removed at the same time. In UV/DIZ and UV/Cr processes that are exposed to ultraviolet radiation alone, only one of them is removed. Also, when these two pollutants are being removed at the same time, the total amount of energy is much less than the total energy consumption of the pollutants one by one.
Research on Biochemical Solidification and Microstructure Characteristics of Bauxite Tailings Clay
Authors: Jiang Jie , Wang Shufei , ou xiaoduo , Su Jian , Mo Peng 
Published: July 2022

Abstract
Microbially induced carbonate precipitation (MICP) has an excellent consolidation effect, but the application in tailings clay is less at present. This work researched the quicklime and microbial co-curing technology (biochemical consolidation technology) to explore the consolidation characteristics and pores microstructure of tailings clay. The results show that: The optimum shear strength and compressibility of solidified soil after biochemical treatment were 30 kPa and 0.19 MPa− 1, which increased by 112.77% and decreased by 38.71% compared with quicklime treatment. The fractal dimension of surface pores was reduced after biochemical treatment and the minimum was 1.136 when the quicklime was 105g. The minimum surface porosity was 4.26%, which was reduced by 76.17% compared with quicklime treatment. The pores shape of solidified soil after biochemical treatment is more regular, and the circularity reached 65.93% in the range of 0.9-1, which is higher than 39.23% of quicklime treatment. The biochemical treatment can fill the narrow pores and make the large pore volume above 50 nm translate into a small volume. The hydrate reaction products could provide a suitable growth environment for bacteria, and the quicklime also as the source of calcium participates in the biochemical reaction. The optimum quicklime content is 105g, and excessive quicklime can increase solidified soil expansion and crack, and a high pH will inhibit bacterial activity. This work could provide a new approach to tailings reservoir stabilization and ensure the effectiveness of bauxite tailings consolidation.
Characterization of a buried quarry by historical analysis of satellite images integrated with electrical resistivity tomography, East Cairo area, Egypt
Authors: Lethy Ahmed , Massoud Usama , Mesbah Hany , Abbas Abbas M. , Said Said Mohamed 
Published: July 2022

Abstract

East Cairo is characterized by abundant quarries that have been used as landfill sites for solid waste. These sites have become part of the urban sprawl of New Cairo, and their detection became difficult from the ground surface. In this study, analysis of multi-temporal high-resolution satellite images and electrical resistivity tomography (ERT) data were used to detect and delineate a buried landfill site located near the Ring Road, East Cairo, Egypt. Analysis of changes detected on the satellite images revealed that the study site was a WNW-oriented Quarry until 2005 and then randomly filled with heterogeneous solid materials. ERT survey was planned based on the result of change detection. On the plan view, the ERT measurements have outlined the electrically conductive zones which are occupied by filling material and distinguished them from the resistive zones that symbolize the natural soil areas. By assimilation of the satellite images and the ERT results, two distinguished geoelectrical units could be perceived; Unit-1 (the upper unit) is characterized by low to moderate resistivity values being the solid waste materials, while Unit-2 (the lower unit) is characterized by high resistivity values that characterize the original soil (bedrock). The closely spaced grid of ERT profiles and the detailed topographic map helped in mapping and delineating the contact between the bedrock and the filling materials. Several parameters could be addressed and were used for characterizing the unit of interest (Unit 1) including ground surface elevation, depth of the lower boundary of Unit-1, and thickness variation of this unit across the investigated site.
A Metal-Catalyzed Functional Group Metathesis Approach to the Carbon Isotope Labeling of Carboxylic Acids
Authors: Kinney R. Garrison , Zgheib José , Lagueux-Tremblay Pierre-Louis , Yang Haifeng , Gauthier Donald , Arndtsen Bruce 
Published: July 2022

Abstract
The distribution, metabolism and ultimate fate of molecules within the body is central to the activity of pharmaceuticals. However, the introduction of radioisotopes into the metabolically stable carbon sites on drugs required to probe these features presents a significant hurdle, since it typically requires synthesis with toxic, radioactive gases such as 14CO2 and 14CO. Here, we describe a straightforward alternative approach to directly carbon-label carboxylic acid-containing pharmaceuticals: via a metal catalyzed functional group exchange reaction. This provides a general route to 14C-labeled carboxylic acid-containing drugs without radioactive gases, in one pot, and using an easily available and handled carboxylic acid 14C-source. To enable this process, a new class of functional group metathesis of carbon-carbon covalent bonds in acid chloride functionalities is developed that exploits the ability of earth abundant nickel catalysts to both reversibly activate carbon-chloride bonds and exchange functionalities between organic molecules. The applicability of this system to drug development is illustrated by the direct incorporation of 14C- or 13C-label into an unprecedented array of complex aryl, alkyl, vinyl and heterocyclic carboxylic acid drugs or drug candidates without gases or special apparatus, at simply ambient conditions, and without loss of the radiolabel.
Effects of width-height ratio and roof-floor strength on the mechanical characteristics of cemented gangue backfill pier-column
Authors: Ran Hongyu , Elchalakani Mohamed , Guo Yuxia , Feng Guorui , Yang Bo 
Published: July 2022

Abstract
Cemented gangue backfill pier-column (CGBP) is the essential supporting component of the goaf in partial backfill mining or constructional backfill mining for controlling the surface subsidence of coal mining. The height of CGBP has been determined by the thickness of the coal seam, and thus the width-height ratio and roof-floor strength directly affect the bearing capacity of CGBP under axial compression. Herein the effect of width-height ratio (1/3 − 1/1) on the mechanical characteristics of CGBP with different curing ages under uniaxial compressive was system studied through experiment, and the damage process was analyzed by ultrasonic equipment and DIC. Based on the experimental results and discrete element theory, a three-phase numerical model for CGBP was established, which considered the real aggregate shape and distribution and the mechanical characteristics of each phase. Then, the effects of the end friction coefficient and the strength ratio of roof-CGBP-floor combination on the strength and failure characteristics of CGBP (large width-height ratio: 1/1–4/1) were investigated. The results show that: CGBP shows the width-height ratio effect obviously and the strength and ductility increase with the increase of the width-height ratio, and the width-height ratio effect increases with the increase of curing age and strength ratio. The end friction constraint is the main reason for the width-height ratio effect, and the higher the friction coefficient is, the larger the width-height ratio effect shows, and the width-height ratio effect disappears without end friction constraint. The increase of the width-height ratio of CGBP and the strength ratio of the roof-CGBP-floor combination increases the strength of the combination. Whether the strength of the combination is greater than that of CGBP may have a roof-floor strength threshold or a strength ratio threshold, which are between 31.44–54.11 MPa and 3.75–6.44, respectively. When the strength of the roof and floor is different, the strength of the combination is mainly controlled by the weak carrier and increases with the increase of the strength of the weak carrier. The peak strain energy of CGBP and combination increases with the increase of end friction coefficient, width-height ratio, and strength of roof and floor.
Zein protein obtained from maize as a novel biodegradable membrane material for oxygen/nitrogen separation: membrane fabrication and characterization
Authors: Dirin Amirreza Malekzadeh , Saljoughi Ehsan , Kiani Shirin , Mousavi Seyed Mahmoud 
Published: July 2022

Abstract
In this study, biodegradable zein protein obtained from maize was used as a novel material to prepare a membrane for oxygen/nitrogen separation. Scanning electron microscopy (SEM), thermogravimetric analysis (TGA), tensile test, X-ray diffraction (XRD) spectroscopy, differential scanning calorimetry (DSC), biodegradability test, and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy were conducted for characterizing the zein membrane, and membrane properties was compared with that of the polymeric membranes reported in the literature. The developed zein membrane showed a significantly high thermal stability. The mechanical properties of the zein membrane were higher or comparable to those of the previously reported dense membranes. In addition, biodegradation in compost was significantly higher than the other membranes reported in the literature. The developed zein membrane provided a significantly high oxygen/nitrogen selectivity at 2 bar, which was superior to most of the previously reported data on the neat biodegradable polymers with dense structure. The permeability of oxygen and nitrogen at 2 bar was 0.67 and 0.12 barrer, respectively, which brought about the selectivity of 5.45 for oxygen/nitrogen separation.