bluuebunny/crossref_metadata_2025_split huggingface dataset:
ENGLISH BLENDED LEARNING: AN ANALYSIS OF INDONESIAN STUDENTS’ PERCEPTION
Authors: Suriaman Aminah , Tadeko Nurgan , Manurung Konder , Usman Sriati , Yuliyani Atik 
Published: July 2022

ABSTRACTThe study attempted to analyze the students of Tadulako University's perspective toward blended learning instruction in English teaching. The study employed a quantitative approach using a longitudinal survey design. 48 English department students in the fourth and sixth semesters were selected as the sample of the research using a simple random sampling technique. The data were gained through the questionnaire distributed online and the interview in the face-to-face technique. Data have been analyzed descriptively and inferentially using SPSS Program version 21. The results showed that blended learning through Moodle-based Instruction and face-to-face learning in the classroom was a modern way of learning, convenient to learn English anywhere and anytime. According to most of the respondents, blended learning is the way to enhance their self-directed learning. They can understand the subject well through blended learning, and students feel satisfied using blended learning in English Teaching. It could be concluded that blended learning is helpful to apply in English teaching. The results contributed theoretical and practical information and references to practitioners and researchers in this field of study. ABSTRAK Penelitian ini mencoba untuk menganalisis perspektif mahasiswa Universitas Tadulako terhadap pengajaran blended learning dalam pengajaran bahasa Inggris. Penelitian ini menggunakan pendekatan kuantitatif dengan menggunakan desain survei longitudinal. 48 mahasiswa jurusan Bahasa Inggris semester empat dan enam dipilih sebagai sampel penelitian dengan menggunakan teknik sampel acak secara sederhana. Data diperoleh melalui kuesioner yang disebarkan secara daring dan wawancara dengan teknik tatap muka. Data dianalisis secara deskriptif dan inferensial menggunakan Program SPSS versi 21. Hasil penelitian menunjukkan bahwa blended learning melalui Pembelajaran Berbasis Moodle dan pembelajaran tatap muka di kelas menurut mahasiswa merupakan cara belajar yang modern, nyaman untuk belajar bahasa Inggris dimana saja dan kapan saja. Blended learning menurut sebagian besar responden, adalah cara untuk meningkatkan self-directed mereka dalam belajar, mereka dapat memahami materi pembelajaran dengan baik melalui blended learning, dan siswa merasa puas menggunakan blended learning dalam Pengajaran Bahasa Inggris. Dapat disimpulkan bahwa blended learning berguna untuk diterapkan dalam pengajaran bahasa Inggris. Hasil penelitian ini memberikan kontribusi informasi dan referensi secara teoritis dan praktis kepada para praktisi dan peneliti selanjutnya dalam bidang studi ini.
Ansiedad, desesperanza y afrontamiento ante el COVID-19 en usuarios de atención psicológica
Authors: Hernández Montaño Alicia , González Tovar José , Garza Sánchez Rosa Isabel , Valdés García Karla , Pérez Pedraza Bárbara De los Ángeles 
Published: July 2022

Objetivo. Identificar los niveles de síntomas de ansiedad y desesperanza, así como, las estrategias de afrontamiento durante la pandemia de COVID-19 en usuarios de servicios de atención psicológica en línea. Método. Se utilizó un diseño de tipo transversal predictivo, con una muestra de 78 personas voluntarias. Se aplicó la Escala de estrategias de afrontamiento frente a riesgos extremos, Inventario de Ansiedad de Beck (BAI) y la Escala de Desesperanza de Beck (BHS). Resultados. Al existir un alto nivel de ansiedad en las personas participantes, se tiende a manifestar mayor nivel de indefensión y de conductas de afrontamiento orientadas hacia la evitación y de naturaleza pasiva.
POVOS INDÍGENAS NO BRASIL OITOCENTISTA
Authors: COSTA JOÃO PAULO PEIXOTO , OLIVEIRA TATIANA GONÇALVES DE 
Published: July 2022

JOÃO PAULO PEIXOTO COSTA
ORCID: http://orcid.org/0000-0001-6767-4104
Doutor em História Social pela UNICAMP
Professor do IFPI e do PROFHISTÓRIA/UESPI
Uruçuí/Piauí/Brasil
joao.peixoto@ifpi.edu.br

TATIANA GONÇALVES DE OLIVEIRA
ORCID: http://orcid.org/000-0001-9496-0077
Doutora em História pela UFRRJ
Professora adjunta da UESPI
Floriano/Piauí/Brasil
tatianagoncalves@frn.uespi.br
EFL Students’ Needs and Achievement: A Study at an Islamic University in Jambi
Authors: Amalia Shynta , Fitria Wahyuni , Ramdhani Muhammad Iqbal , Suryani Hilma 
Published: July 2022

This study aims to respond the regulation of teaching and learning English in higher education. Since there is no clear regulation of what supposed to be taught, some institutions decide different requirement for the teaching and learning English. This study focused on analyzing and evaluating the students’ actual needs in learning English. A quantitative study was conducted toward 113 non-English department students who have taken English subject in an Islamic University in Jambi. This study explored both of the students’ actual needs and experiences of their learning English in the classroom. The results indicate that having the four skills as a part of teaching and learning English in the classroom is important for the students. The students also mentioned that completing their study is not the only reason to learn English. They believe that learning English is a golden key to be a part of world class community. In spite of mastering reading as the main focus of learning process, the students still face difficulties in understanding the ideas in English since they have limited vocabulary and grammar. They also stated that it is hard for them to get the meaning of what they read because they do not know how the sentences are put together. As the results, it is suggested that the process of teaching and learning English must be revisited
Implementasi Google Classroom pada Studi Kelayakan Bisnis Mahasiswa IKIP PGRI Bojonegoro
Authors: Zuhriah Fifi , Fadhillah Mia Nur , Utami Anita Dewi 
Published: July 2022

Penelitian ini merupakan penelitian kualitatif dengan menggunakan pendekatan desktiptif kualitatif. Penelitian ini bertujuan untuk mendeskripsikan implementasi aplikasi Google Classroom pada mata kuliah studi kelayakan bisnis di IKIP PGRI Bojonegoro. Populasi pada penelitian ini adalah mahasiswa Pendidikan Ekonomi tingkat II Fakultas Ilmu Pendidikan Sosial di IKIP PGRI Bojonegoro tahun ajaran 2020/2021 dengan jumlah 32 mahasiswa. Pengumpulan data menggunakan metode observasi, wawancara, dokumentasi. Berdasarkan hasil penelitian proses pembelajaran studi kelayakan bisnis dengan menggunakan aplikasi Google Classroom di masa pandemi covid-19 teridiri dari tiga kegiatan yaitu kegiatan pembuka, kegiatan inti, kegiatan penutup. Namun pada kenyataannya memang kegiatan pembuka, inti dan penutup di aplikasi Google Classroom tampak samar namun setiap kegiatan sudah terlaksanakan dan tujuan pembelajaran sudah tercapai. Aplikasi Google Classroom dapat diterima mahasiswa dalam
pembelajaran daring selain itu performa Google Classroom juga optimal dan memudahkan kegiatan pembelajaran.
Results of geological and geophysical study of the deep structure of Angara and Trans-Baikal mantle plumes and their connection with mineral deposits.
Authors: Kharitonov A. L. 
Published: July 2022

The purpose of the article is to consider the issues of geological and geophysical interpretation of the data of balloon and satellite magnetic measurements along the regional profile crossing the territory of the Angara-Baikal region. In order to conduct scientific research along the regional Trans-Siberian geological and geophysical profile A-B the author used various geological and geophysical materials including the magnetic field digital data measured by the MAGSAT artificial Earth satellite and a balloon; data on the values of the electrical resistivity in the mantle of this region; geothermal data; seismic data on the location of earthquake hypocenters in the area of the profile under investigation. The research methods involved multilevel measurements of satellite and balloon magnetic fields, which significantly expanded the possibilities of geological and geophysical interpretation of the data obtained. The conducted study revealed that the geological and geophysical interpretation of multilevel aeromagnetic data allows for a reasonably accurate determination of the location coordinates and lithospheric penetration depth of tectonic faults associated with the Angara and Trans-Baikal mantle plumes, which are of significant interest in terms of exploration of coal and uranium deposits. The spatial and depth characteristics of tectonic faults obtained from balloon and satellite data are confirmed by a set of analyzed independent geophysical data: magnetotelluric sounding, geothermy, seismology and other geophysical methods. In conclusion it should be noted that the author has demonstrated the application possibility of satellite and balloon magnetic surveys for the study of the deep structure of the Angara and Trans-Baikal mantle plumes. In addition, it was found out that according to balloon and satellite magnetic data, large deep tectonic faults in the lithosphere (Barguzinsky, Ikatsky, Tukolamsky, Tungirsky) can be identified, which also allow marking various subhorizontal boundaries of lithospheric layers in the location area of the Angara and Trans-Baikal mantle plumes using special points of the magnetically active zones of these faults. The practical significance of the conducted research is in the identification of the spatial relationship between the location of the Angara mantle plume and coal deposits of the Irkutsk basin, as well as uranium deposits in the zone of the Trans-Baikal mantle plume.
N-3 Polyunsaturated Fatty Acids and Gut Microbiota
Authors: Lim Sun Young , Jayapala Hettiarachchige Priyanga Sajeewanie 
Published: July 2022

Abstract:
For several decades, studies have reported that n-3 polyunsaturated fatty acids (PUFAs)
play a beneficial role in cardiovascular, immune, cognitive, visual, mental and metabolic health.
The mammalian intestine is colonized by microbiota, including bacteria, archaea, viruses, protozoans,
and fungi. The composition of the gut microbiota is influenced by long-term dietary habits,
disease-associated dysbiosis, and the use of antibiotics. Accumulating evidence suggests a relationship
between n-3 PUFAs and the gut microbiota. N-3 PUFAs can alter the diversity and abundance
of the gut microbiome, and gut microbiota can also affect the metabolism and absorption of n-3
PUFAs. Changes in the populations of certain gut microbiota can lead to negative effects on
inflammation, obesity, and metabolic diseases. An imbalanced consumption of n-3/n-6 PUFAs
may lead to gut microbial dysbiosis, in particular, a significant increase in the ratio of Firmicutes to
Bacteroidetes, which eventually results in being overweight and obesity. N-3 PUFA deficiency disrupts
the microbiota community in metabolic disorders. In addition, accumulating evidence indicates
that the interplay between n-3 PUFAs, gut microbiota, and immune reactions helps to maintain
the integrity of the intestinal wall and interacts with host immune cells. Supplementation with
n-3 PUFAs may be an effective therapeutic measure to restore gut microbiota homeostasis and correct
metabolic disturbances associated with modern chronic diseases. In particular, marine extracts
from seaweed contain a considerable dry weight of lipids, including n-3 PUFAs such as eicosapentaenoic
acid (EPA, C20: 5) and docosahexaenoic acid (DHA, C22: 6). This review describes how
gut microbiota function in intestinal health, how n-3 PUFAs interact with the gut microbiota, and
the potential of n-3 PUFAs to influence the gut-brain axis, acting through gut microbiota composition.
Overexpression of Efflux Pumps AcrAB and OqxAB Contributes to
Ciprofloxacin Resistance in Clinical Isolates of K. pneumoniae
Authors: Albarri Osman , AlMatar Manaf , Öcal Melda Meral , Köksal Fatih 
Published: July 2022

Background:
Infection caused by multidrug-resistant K. pneumoniae is regarded as a severe public health concern worldwide, with most countries reporting an increase in fatality rates over time. Efflux pumps are significant determinants of acquired and/or intrinsic resistance in K. pneumoniae.

Objectives:
Our aim is to explore efflux-mediated resistance mechanisms in K. pneumoniae by using quantitative real-time PCR in order to evaluate the expression of efflux pump genes (acrA, acrB, oqxA, and oqxB) and pump regulators (marA, soxS, and rarA).

Method:
Efflux pump inhibitor CCCP was able to a reduce MIC values of ciprofloxacin by 2 to 64-fold in 43/46 (93%) of MDR-K. pneumoniae isolates.

Results:
Compared to the control strain (untreated one), our results demonstrated that acrA, acrB, oqxA, oqxB, marA, soxS, and rarA were overexpressed in 29 (63%), 24 (52%), 29 (63%), 24 (52%), 17 (37%), 16 (35%), and 16 (35%) of K. pneumoniae isolates, respectively. Additionally, a positive correlation was established between the expressions of acrAB and marA (r = 0.50, r = 0.45, respectively) and oqxAB and rarA (r = 0.462912, r = 0.519354, respectively).

Conclusion:
Ciprofloxacin resistance was caused by overexpression of the efflux pump genes acrAB and oqxAB, as well as the transcriptional regulators marA, soxS, and rarA in clinical isolates of K. pneumonia.
Plasma Phage Load is Positively Related to the Immune Checkpoints in
Patients Living with Human Immunodeficiency Virus
Authors: Su Fei-Fei , Zheng Xiao‑Qun , Huang Kai‑Zhao , Ye Hui , Fang Yang-Yang , Li Tao , Pei Shun-Jie , Wu Lian-Peng 
Published: July 2022

Background:
Microbial translocation (MT) and altered gut microbiota are involved in immune activation and inflammation, whereas immune checkpoint proteins play an important role in maintaining immune self-tolerance and preventing excessive immune activation.

Objective:
This study aims to investigate the relationship between plasma phage load and immune homeostasis in people living with HIV(PLWH).

Methods:
We recruited 15 antiretroviral therapy (ART)-naive patients, 23 ART-treated (AT) patients, and 34 healthy participants (HP) to explore the relationship between the plasma phage load and immune checkpoint proteins. The deoxyribonucleic acid (DNA) load of the lambda (λ) phage was detected using fluorescence quantitative polymerase chain reaction (PCR). The immune checkpoints (ICPs) were detected using multiplex immunoassay.

Results:
Our study demonstrated that the plasma phage load was increased in people living with HIV (PLWH) (P<0.05), but not in the ART-naive and AT groups (P>0.05). Plasma ICPs, including cluster of differentiation 27 (CD27), soluble glucocorticoid-induced tumor necrosis factor (TNF) receptor (sGITR), soluble cluster of differentiation 80 (sCD80), sCD86, soluble glucocorticoid-induced TNF receptor-related ligand (sGITRL), soluble induced T-cell costimulatory (sICOS), sCD40, soluble toll-like receptor 2 (sTLR2), and sCD28, were markedly decreased among the ART-naive group (P<0.05) but not in the AT and HP groups (P>0.05). The plasma phage load was positively correlated with ICP and C-reactive protein (CRP) levels in PLWH (P<0.05).

Conclusion:
Our study indicated that the plasma phage load in PLWH was positively related to the expression of ICPs and inflammation, which may be used as a promising marker for the immune level of PLWH.
The Therapeutic Potential of Panax Ginseng and Ginger on Postsurgical
Adhesion Band Formation
Authors: Nazari Seyedeh Elnaz , Khalili-Tanha Ghazaleh , Mobasheri Leila , Asgharzadeh Fereshteh , Naimi Hamideh , Eskandari Moein , Askarnia-Faal Mohammad-Mostafa , Hassanian Mehr Seyed Mahdi , Gharib Masoumeh , Ghorbani Hamid Reza , Aliakbarian Mohsen , Ferns Gordon A , Khazaei Majid , Avan Amir 
Published: July 2022

Background:
Peritoneal adhesions (PA) are a common complication of abdominal operations.
Previous studies indicate that inhibition of inflammation and fibrosis at sites of peritoneal damage may
prevent the development of intra-abdominal adhesions. Zingiber officinalis Roscoe (ginger) and Panax
ginseng (P. ginseng) are herbal products with antioxidant and anti-inflammatory effects that can have
restorative properties.

Objective:
This research aimed to examine the impact of ginger and p. ginseng on prevention of PA in a rat model after surgery.

Methods:
Following a laparotomy, the wall of the cecum was rubbed to induce intra-abdominal adherence
in Wistar rats. Ginger (400mg/kg) and P. ginseng (500mg/kg) were orally adminstered to the animals.
The animals were sacrificed on the 10th day after surgery, and the Nair and Leach scoring system
was used to assess adhesion. The microscopic histology of the induced cecal adhesions was evaluated. An
enzyme-linked immunosorbent assay (ELISA) was used to determined tissue levels of transforming
growth factor-beta (TGF-β) on homogenized PA tissue. Real-time PCR was performed to quantify the
mRNA expression of IL-1β, TNF-α, Col 1a1, and Col 3a1 in rat tissue.

Results:
The adhesion score and histopathological rating based on the Nair and Leach scoring criteria
showed lower adhesion scores in the group of rats treated with P. ginseng compared to the control group
(p<0.05). Treatment with ginger and P. ginseng was associated with reduced tissue level of TGF-β and
mRNA expression of TNF-α and IL-1β. The gene expression level of Col 1a1 and Col 3a1 were markedly
decreased in the P. ginseng group.

Conclusion:
The study's outcome recommends that P. ginseng could be an effective agent for preventing
the PA and inflammation during the post-operative stage.
Novel Delivery Technologies: Triggering the Biopharmaceutical Potential
of Boswellic Acids
Authors: Marbaniang Daphisha , Das Anup Kumar , Pal Paulami , Gogoi Niva Rani , Saikia Ananta , Ray Subhabrata , Mazumder Bhaskar 
Published: July 2022

Abstract:
Boswellic acids are a series of pentacyclic triterpenes derived from the gum resin of Boswellia
Genus, mostly from Boswellia serrata Roxb. (Burseraceae) tree commonly known as Indian
Frankincense or salai guggul and traditionally used as an anti-inflammatory agent. It acts by inhibiting
5-Lipoxygenase, C3-convertase, cyclooxygenase, preferably COX-1, Human Leukocyte Elastase, NF-
κB expression, Topoisomerase I and II and microsomal Prostaglandin E2 synthase-1. Boswellia species
are reported to have various pharmacological potentials like anti-inflammatory, anti-cancer, antimicrobial,
anti-arthritic, immunomodulatory activity, neuroprotective activity, and are also proved to
be effective against ileitis, ulcerative colitis, hypolipidemic, hypertension and hepatotoxicity. Regardless
of their multiple uses, pharmacokinetic studies of Boswellic acids revealed their poor oral bioavailability,
high lipophilicity, and their degradation by the hepatic Phase I mechanism. With low solubility
and poor bioavailability, different approaches have been applied to improve the poor pharmacokinetic
profile of Boswellic acids. Designing and developing novel delivery systems for their enhanced
permeability and improved bioavailability with better efficacy have been of great interest.
Assessment of Shear Bond Strength and Cytotoxicity of Orthodontic
Adhesive with Addition of Silver Nanoparticles in Varying Concentrations
Authors: Soans Crystal R. , Shashidhar Keerthan , Shersha Shalin , Mansoor Rahila , Gauthami K. 
Published: July 2022

Background:
Prolonged treatment with fixed orthodontic appliances tend to compromise oral hygiene maintenance in patients, increasing their susceptibility to white spot lesions and caries. Incorporating silver nanoparticles into adhesives and orthodontic appliances is known to improve its antimicrobial properties.

Aim and objectives:
The aim of the present study was to assess and compare the bond strength of orthodontic adhesive when Silver Nanoparticles were added in varying concentrations and also to assess their cytotoxicity on periodontal ligament fibroblasts.

Materials and methods:
Various concentrations of silver nanoparticles (1%, 5%, 10%w/w) were incorporated into Transbond XT composite adhesive and their shear bond strength and cytotoxicity were compared to a control group. Brackets were bonded to extracted premolar teeth and shear bond strength was assessed using Instron Universal Testing Machine. The viability of periodontal ligament fibroblasts was assessed after incubating with the experimental composite for 24 hours and 1 week using MTT assay.

Results:
There was a decrease in the shear bond strength when 1% and 5% of silver nanoparticles were incorporated into the adhesive.However, it was within the clinically recommended range for bonding brackets. When the concentration was increased to 10%, the SBS was not acceptable for orthodontic bonding. The composite incorporated with silver nanoparticles was cytotoxic to fibroblasts at all concentrations at both time intervals.

Conclusion:
The shear bond of orthodontic adhesive with nanosilver is comparable to plain transbond XT in low concentrations, however, the addition of silver nanoparticles seems to increase the time-bound cytotoxicity of orthodontic adhesive.
Establishment of Analyzing Method of Fenpropathrin Residue in
Angelica dahurica Radix and Osterici Radix
Authors: Hur Jang-Hyun , Ham Hun-Ju , Lee Byung-gi , Choi Jeong-Yoon , Ahmed Ishag Abd Elaziz Sulieman 
Published: July 2022

Background:
Angelica dahurica Radix and Osterici radix, are perennial herbs belonging to the family Umbelliferae, which were attacked by red spiders, thus fenpropathrin was registered. Fenpropathrin is important in improving productivity and quality of medicinal herbs due to timely pest control. However, residue may likely remain after harvest, and therefore, the residue analysis is important to ensure pesticides safety management.

Objective:
This study aimed to establish analysis method for fenpropathrin residues in A. dahurica Radix and O. radix using GLC-ECD and GC-MS/MS.

Methods:
Samples were moisturized with distilled-water and extracted with acetonitrile. The interferences were removed using SPE cartridges and analyzed by GLC-ECD and GC-MS/MS.

Results:
Based on pre-experiment results, the analysis method was optimized using double-cleanup method (SPE-GCB/NH2 & SPE silica cartridges). Fenpropathrin peak confirmed by GC-MS at the same retention time and with its mass numbers. Nevertheless, the cleanup processes are laborious and require a rather long time. Thus, additional effortless analysis method was developed using the d-SPE method that can apply to highly selective and sensitive GC-MS/MS. The LOD of GC-ECD and GC-MS/MS was 0.1 and 0.01 ng, respectively. While the LOQ was 0.04 mg/kg for both. Linearity (r2) was > 0.998 (GLC-ECD) and 0.999 (GC-MS/MS). The recoveries at three spiking levels ranged 83.6-103.1% and 89.6-98.0% for A. dahurica Radix and O. radix, respectively.

Conclusion:
Accuracy of the improved method met the standard of the Korean Ministry of Food and Drug Safety. Therefore, the developed methods expected to be used for analyzing pesticide residues in herbal medicines in Korea and other countries.