bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of SARS-CoV-2 Infection in the Older Adult Population: Data From the LOST in Lombardia Study
Authors: Mosconi Giansanto , Stival Chiara , Lugo Alessandra , Signorelli Carlo , Amerio Andrea , Cavalieri Luca , Iacoviello Licia , Stuckler David , Zucchi Alberto , Odone Anna , Gallus Silvano 
Published: February 2022

Abstract

Most COVID-19-related fatalities occurred among older adults, however to date, evidence on determinants of SARS-CoV-2 infection in this population is limited and mostly based on case series without a comparison group. A telephone-based cross-sectional study was conducted in November 2020 on a representative sample of 4,400 Italians aged ≥65 years residing in the Lombardy region. We determined the prevalence of a history of SARS-CoV-2 infection in the period between the beginning of the pandemic and the time of the interview. Thorough unconditional multiple logistic regression models, we estimated odds ratios (OR) of SARS-CoV-2 infection and the corresponding 95% confidence intervals (CI). We also evaluated if the infection was a determinant of a worsening in mental health wellbeing. Overall, 4.9% of participants reported a history of SARS-CoV-2 infection. No significant relationship between sex and SARS-CoV-2 infection was observed. SARS-CoV-2 infection was less frequently reported in subjects aged ≥70 (OR=0.55; 95% 0.41-0.74) compared to 65-69 years. No trend was observed after 70 years of age. Those with at least one chronic condition reported a lower infection rate compared to healthy subjects (OR=0.68 95% CI: 0.49-0.93). Separated/divorced participants less frequently reported infection than married/cohabiting ones (OR=2.33 95% CI: 1.29-4.20). Self-reported history of SARS-CoV-2 infection resulted being a determinant of an increase in depressive symptoms (OR=1.57; 95% CI: 1.17-2.10). This first large representative study of people aged 65 years or over suggests that in Italy the oldest subjects and those having chronic conditions less frequently expose themselves to SARS-CoV-2 infection during the pandemic.
To Explore the Network Pharmacology and Molecular Docking Mechanism of Chaihu Shugan Powder with the “Same Treatment for Different Diseases” for Insomnia and Depression Based on the COVID-19 Pandemic
Authors: Wang Liang , Wang Peng , Chen Yingfan , Li Chen , Wang Xuelin , Li Mingwei , Luan Zhenxian , Zhang Yin , Li Shaodan , Yang Minghui 
Published: February 2022

Abstract
Background: The classic prescription Chaihu Shugan Powder (CHSGP) has been widely used in clinical Chinese medicine treatment and has clear clinical effects in the treatment of emotional diseases. Based on the increasing incidence of emotional diseases such as insomnia and depression in the population during the COVID-19 pandemic, we will explore the mechanism of CHSGP in the treatment of insomnia and depression with “Same Treatment for Different Diseases”. Methods: Using a bioinformatics and network pharmacology platform, protein database and STRING database, we collected CHSGP chemical composition and related target data and constructed a "component-target" action network through Gene Ontology and Kyoto Encyclopedia of Genes and Genome pathway enrichment analysis. Molecular docking technology was used to verify key active ingredients and core targets. Results: A total of 119 active compounds of CHSGP were screened, such as quercetin, kaempferol, and β-sitosterol, and 113 common related targets overlapped with insomnia and depression. GO enrichment and KEGG pathway analysis mainly involved immune, inflammation, cell proliferation, apoptosis, endocrine and other related targets and signaling pathways. Molecular docking showed that small molecular compounds (kaempferol, luteolin, quercetin, 7-methoxy-2-methyl isoflavone and beta-sitosterol) had good binding effects with five target proteins (AKT1, IL1B, IL-6, FOS, GSK3B) to play a role in regulating immunity, the inflammatory response, cell proliferation, apoptosis, and endocrine signaling. Conclusions: Under the context of the COVID-19 pandemic, it revealed the complex mechanism of multicomponent, multitarget, and multipathway of the classic CHSGP for insomnia and depression, laying a theoretical foundation for its clinical application of its "same treatment for different diseases".
Heterogeneity in BIRC3 and ATM Alterations in del(11q) Chronic Lymphocytic Leukemia
Authors: Galvano Camila , Krzywinski Andrea , Stanganelli Carmen , Rodríguez Cecilia M. , Heller Viviana , Miodosky Marcela , Cugliari Silvana , Bezares Raimundo , Slavutsky Irma 
Published: February 2022

Abstract
Deletion 11q22 [del(11q)] is among the most common chromosomal alteration in chronic lymphocytic leukemia (CLL). This anomaly is highly variable in size and may be distinguished in large and small deletions. The minimal deleted region on 11q usually includes ATM gene and can also encompass the BIRC3 locus, located 6 Mb centromeric to ATM, in approximately 80% of cases. In this study, we have evaluated BIRC3 and ATM losses and their association with adverse prognostic factors in CLL patients. Thirty-three out of 200 patients (16.5%) sequentially studied in our laboratory harbored del(11q). Our study shows a predominant presence of concomitant ATM and BIRC3 deletions but with differences in the percentage of abnormal cells: 54.5% of cases had similar ATM and BIRC3 percentages, 9.1% showed higher frequency of ATM deletion and 21.2% increased percentage of BIRC3 loss, indicating clonal evolution. Interestingly, 9.1% patients presented only BIRC3 deletion and 6.1% cases showed only ATM loss, suggesting the inclusion of BIRC3 analysis in the routine FISH laboratory screening. A strong association between ATM and BIRC3 deletions with TP53 loss (48.5%), complex karyotypes (36%), unmutated IGHV (72.7%) and intratumor heterogeneity (51.5% patients) was observed. A short time to first treatment (p<0.0001) in cases with del(11q) compared to patients with 13q14 deletion single and without cytogenetic alterations was also found, highlighting the increased genomic instability and poor outcome present in this subgroup of patients.
Ultra-durable Ni-Ir/MgAl2O4 catalysts for dry reforming of methane enabled by dynamic balance between carbon deposition and elimination
Authors: Li Haocheng , Hao Cong , Tian Jingqing , Wang Shuai , Zhao Chen 
Published: February 2022

Abstract
Carbon deposition is the main cause for the catalyst deactivation of methane dry reforming, and researchers are committed to exploring effective catalyst systems with zero carbon deposition in order to achieve a practically long life-time. In this work, we propose an equilibrium theory with matched rates of CH4 dissociation and CO2 activation to establish a balance between carbon deposition and carbon elimination, and construct highly dispersed Ni-Ir/MgAl2O4 alloy catalysts accordingly, where Ni activated CH4, MgAl2O4 adsorbed CO2 to form surface carbonates, and Ir effectively utilized the carbonates to eliminate carbon species generated by CH4 dissociation. Theoretical assessment further unveiled that the preferred CO2 activation on Ir over Ni is derived from its stronger oxophilicity. With an optimal Ni/Ir atomic ratio of 1/2, high activity and long-period stability (600 h) with zero carbon deposition were obtained concurrently for dry reforming of methane at industrially-relevant temperature (650 ℃).
Early Neurological Deterioration in Acute Ischemic Stroke Patients after Intravenous Thrombolysis with Alteplase Predicts Poor 3-Month Functional Prognosis - Data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China)
Authors: Che Fengli , Wang Anxin , Ju Yi , Ding Yarong , Duan Honglian , Geng Xiaokun , Zhao Xingquan , Wang Yongjun 
Published: February 2022

Abstract
Background： We aimed to investigate the risk factors of early neurological deterioration (END) after intravenous thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) and the relationship between END and poor 3-month functional outcomes.Methods: Patients who accepted intravenous recombinant rt-PA were enrolled continuously. END was defined as an increase of National Institute of Health Stroke (NIHSS) score ≥ 4 points or death within 24 hours after intravenous thrombolysis. The modified Rankin Scale (mRS) score was recorded to evaluate the functional prognosis of stroke, and the poor 3-month prognosis was defined as an mRS score ≥ of 3. Univariate and multivariate analyses were used to analyze the risk factors of END. The relation between END and 3-month functional outcome was analyzed by multivariate logistic regression analysis. Results: A total of 1107 patients (mean age, 63.42±11.33 years; 673 males) were included in the final analysis, and 81(7.32%) patients had END. In multivariate analysis, the serum glucose level was significantly associated with END; the odds ratio was 1.10 (95% CI 1.03 to 1.18, p =0.004). The multivariate logistic analysis showed END has a notable association with the poor 3-month functional recovery even after adjusting for confounding factors; the adjusted OR was 8.25 (95% CI 3.77 to 18.03, p<0.0001). Conclusions: The initial serum glucose level might be an independent risk factor of END, and END might predict a poor 3-month prognosis.
Differential impact of rhamnolipids and TWEEN80 on the composition and functionality of the gut microbiota in the SHIME system.
Authors: Miclotte Lisa , Paepe Ellen , Li Qiqiong , Camp John , Raikovic Andreja , Wiele Tom , Rymenans Leen 
Published: February 2022

Abstract
Background: Dietary emulsifiers have been shown to affect the composition and function of the gut microbial community, both in vivo and in vitro. Yet, several knowledge gaps remain to be addressed: the impact from a longer timeframe exposure on the gut microbiota, interindividual variability in microbiome response and the putative impact from novel clean label alternatives for current food emulsifiers.Results: In the present study, the impact of one conventional dietary emulsifier, TWEEN80, and one potential novel alternative, rhamnolipids, on the human gut microbiota was investigated using the Mucosal Simulator of the Human Intestinal Microbial Ecosystem (M-SHIME). The faecal microbiota from two human donors, with high and low responsiveness to the emulsifiers, were exposed to 0,05 m% and 0,5 m% of the emulsifiers for 7 days. The results confirmed previous observations that the effects on the composition and functionality are both emulsifier- and donor dependent. The effects reached an equilibrium after about 3 days of exposure. Overall, TWEEN80 and rhamnolipids displayed opposite effects: TWEEN80 increased cell counts, reduced propionate concentration, increased butyrate levels, increased a.o. Faecalibacterium, Blautia and Hungatella abundance, while rhamnolipids did the opposite. Rhamnolipids also sharply increased the abundance of unclassified Lachnospiraceae. On the other hand, both emulsifiers increased the relative abundance of unclassified Enterobacteriaceae. Both emulsifiers also altered the microbial metabolome in different ways and a pathway enrichment analysis tool revealed that the metabolome alterations could be reminiscent of gut issues and obesity.Conclusions: Overall, the impact from the rhamnolipids was larger than that of TWEEN80 at similar concentrations, indicating that the former may not necessarily be a safer alternative for the latter. The microbiota’s response also depended on its original composition and the sensitivity status for which the faecal donors were selected, was preserved. Whether the same donor-diversity and longitudinal impact can be expected in the human colon as well and what impact this has on the host will have to be further investigated.
Analysis of the evolutionary characteristics of indirect energy flow and dependence among Chinese industrial sectors
Authors: Jia Yanjing , Dong Zhiliang 
Published: February 2022

Abstract
Background: The diversification of product production and consumption generates closer links between industrial sectors and increases the complexity of indirect energy flows between industrial sectors and interdepartmental interdependence. Methods: We calculated the indirect energy flows between various industrial sectors in 2002, 2007, 2012 and 2017. Then, we have built four indirect energy flow networks and explored the characteristics and the interdependence of indirect energy consumption between sectors. Finally, a quadratic assignment procedure correlation analysis was performed to clarify the relationship between the indirect energy flow relationship and the dependence relationship between industrial sectors.Results: Different industrial sectors play different roles in the process of indirect energy consumption, with a more concentrated indirect energy supply among industrial sectors compared with consumption and a gradual shift in the indirect energy supply from the chemical industry to the service industry. Higher and more stable flow paths that carry indirect energy flows and clearer interdepartmental dependencies are reflected in the upstream and downstream links of the industrial chain. The correlation between indirect energy flows and interdepartmental dependencies is gradually increasing but requires improvements to further optimize China’s industrial structure and reduce energy consumption.Conclusions: Efforts should be made to reduce the energy supply in the chemical sector, optimize the quality of the energy supply in the service sector, and reduce energy consumption. Appropriate attention should be focused on the indirect energy flow relationship between the upstream and downstream industries of the industrial chain, and the integrity of the domestic industrial chain can be improved to reduce the total energy consumption.
Improving Mental Health Outcomes for Black and Minority Ethnic Communities: A Quantitative Study into Perception of Control
Authors: Joseph Stephen , Keating Frank 
Published: February 2022

Background: Although the disparities in mental health outcomes for ethnic minorities in the United Kingdom are well-documented, little is known about the role perception of control plays in the experiences of service users and its role in perpetuating or improving health inequalities. This quantitative methods study investigated the perspectives of the members of these communities from the Locus of Control domain. Methods: A small-scale survey (N=50), applied a purposive sampling method to recruit mental health service users of African and Caribbean origin from a South London Borough to complete two structured questionnaires. Data were analysed using SPSS in the examination of the scores, various demographic variables, linear relationships, and other reliability tests. Results: Key findings indicate a moderate to high externality in LOC scores for participants, in general and mental health milieus, with some remarkable differences in ethnicity, gender, and age. Conclusion: The results present some implications and opportunities for mental health services, policy, and professionals in engaging with clients from this target group towards addressing the inequality of outcomes.
Evolution of landscape dynamics in the Yangtze River Delta from 2000 to 2020
Authors: Zhou Zhe Chen , Wang Jun 
Published: February 2022

Abstract
Based on the 2000–2020 land cover data, the landscape dynamics and landscape pattern index are used to study the landscape pattern changes of the Yangtze River Delta. The results show that with the growth of built-in land area, the dominance of natural landscape in the Yangtze River Delta is gradually weakened. From the perspective of the overall landscape pattern, the degree of landscape fragmentation in this area is increasing, and the degree of landscape connectivity and aggregation are decreasing in varying degrees. The regional landscape is developing toward homogeneous distribution and increasing complexity. At the same time, from the perspective of classified landscape, the spatial distribution of various landscapes shows a strong correlation between climate and landform. Through comparative analysis, this study puts forward that the development of the Yangtze River Delta needs to pay attention to maintaining the integrity of the regional dominant landscape and paying attention to the diversity and connectivity of the natural landscape with high ecological service value.
Effects of face masks and ventilation on the risk of SARS-CoV-2 respiratory transmission in public toilets: a quantitative microbial risk assessment
Authors: Denpetkul Thammanitchpol , Pumkaew Monchai , Sittipunsakda Oranoot , Leaungwutiwong Pornsawan , Mongkolsuk Skorn , Sirikanchana Kwanrawee 
Published: February 2022

Abstract
Public toilets may increase the risk of COVID-19 infection via airborne transmission; however, related research is limited. We aimed to estimate SARS-CoV-2 infection risk through respiratory transmission using a quantitative microbial risk assessment framework by retrieving SARS-CoV-2 concentrations from the swab tests of 251 Thai patients. Three virus-generating scenarios were investigated: an infector breathing, breathing with a cough, and breathing with a sneeze. The infection risk (95th percentile) was as high as 10−1 with breathing and increased to 1 with a cough or a sneeze. No significant gender differences for toilet users (receptors) were noted. The highest risk scenario, namely breathing with a sneeze, was further evaluated for risk mitigation measures. Mitigation to a lower risk under 10−3 succeeded only when the infector and the receptor both wore N95 respirators or surgical masks. Ventilation of up to 20 air changes per hour (ACH) did not decrease the risk. However, an extended waiting time of 10 min between an infector and a receptor resulted in approximately 1.0-log10 further risk reduction when both wore masks with the WHO-recommended 12 ACH. The volume of expelled droplets, virus concentrations, and receptor dwell time were identified as the main contributors to transmission risk.
Practical pressure management for a gradual transition from intermittent to continuous water supply
Authors: Sánchez David H. , Sánchez-Navarro Jesús R. , Navarro-Gómez Carmen J. , Renteria Marusia 
Published: February 2022

Abstract
Cities in developing countries that do not consider water resources as the basis for sustainable growth usually accept intermittent water supply (IWS) as the alternative to satisfy the demand of the population. Networks designed as constant water supply (CWS) operated as IWS hinder a safe and reliable water supply; thus, feasible alternatives to return the operation to CWS are required. This paper presents a methodology based flow/pressure control to accomplish an efficient transformation from an IWS sector to a CWS in the City of Chihuahua, Mexico. The management of pressure at sector entrance and critical supply points leads to successful improvement of service, ensuring water availability with adequate pressure at the peak of demand, as well as reducing the supply of water volume by 58% compared to the sector operated in IWS. The methodology allowed the improvement of decision-making and operating policy for the water operating agency (WOA), fixing service deficiency, avoiding the loss of water volumes, and maintaining competent management control. Nonetheless, resistance to the transition of using automation and setting the volume/pressure consumption based on reliable data persists. The change process will be successful to the extent that the WOA efficiently channels the participation of the personnel.
Recent Developments in Targeting Bromodomain and Extra Terminal
Domain Proteins for Cancer Therapeutics
Authors: Cai Maohua , Dong Jinyun , Li Haobin , Qin Jiang-Jiang 
Published: February 2022

Abstract:
Bromodomain and extra-terminal domain (BET) proteins are a well-studied
family of proteins associated with a variety of diseases, including malignancy and chronic
inflammation. Currently, numerous pan BET inhibitors have exhibited potent efficacy
in several in vivo preclinical models and entered clinical trials but have largely stalled
due to their adverse events. Therefore, the development of new selective inhibitors and
PROTACs (Proteolysis Targeting Chimeras) targeting BET is urgently needed. In the present
review, we summarize the BET protein structure and the recent development in BET
inhibitors, focusing mainly on BRD4-selective inhibitors and PROTAC degraders.
The Complete Chloroplast Genome Sequence of Cicer bijugum, Genome
Organization, and Comparison with Related Species
Authors: Temel Melih , Kaymaz Yasin , Ateş Duygu , Kahraman Abdullah , Tanyolaç Muhammed Bahattin 
Published: February 2022

Background:
Chickpea is one of the legumes that is very important for Turkey and is frequently preferred especially in human nourishment thanks to its rich nutritional content. Chloroplasts, which have their own genetic material, are organelles responsible for photosynthesis in plant cells and their genome contains non-trivial information about the molecular features and evolutionary process of plants.

Objective:
Current study aimed at revealing complete chloroplast genome sequence of one of the wild type Cicer species Cicer bijugum and comparing its genome with cultivated Cicer species Cicer arietinum by using bioinformatics analysis tools. There are no study about revealing chloroplast genome sequence of Cicer species except the cultivated one Cicer arietinum. Therefore, we targeted to reveal the complete chloroplast genome sequence of wild type Cicer species Cicer bijugum and compare the chloroplast genome of Cicer bijugum with the cultivated one Cicer arietinum.

Methods:
In this study, we sequenced the whole chloroplast genome of Cicer bijugum, one of the wild types of chickpea species, with the help Next Generation Sequencing platform and compared it with the chloroplast genome of the cultivated chickpea species, Cicer arietinum by using online bioinformatics analysis tools.

Results:
We determined the size of the chloroplast genome of C. bijugum as 124,804 bp and found that C. bijugum did not contain an inverted repeat region in its chloroplast genome. Comparative analysis of the C. bijugum chloroplast genome uncovered thirteen hotspot regions (psbA, matK, rpoB, rpoC1, rpoC2, psbI, psbK, accD, rps19, ycf2, ycf1, rps15 and ndhF) and seven of them (matK, accD, rps19, ycf1, ycf2, rps15 and ndhF) could potentially be used as strong molecular markers for species identification. It has been determined that C. bijugum was phylogenetically closer to cultivated chickpea as compared to the other species.

Conclusion:
It is aimed that the data obtained from this study, which is the first study in which whole chloroplast genomes of wild chickpea species were sequenced, will guide researchers in future molecular, evolutionary and genetic engineering studies with chickpea species.