bluuebunny/crossref_metadata_2025_split huggingface dataset:
Capsular Mechanics After Periacetabular Osteotomy for Hip Dysplasia
Authors: Ng K.C. Geoffrey , Bankes Marcus J.K. , El Daou Hadi , Beaulé Paul E. , Cobb Justin P. , Jeffers Jonathan R.T. 
Published: February 2022

Background:
Hip dysplasia is characterized by insufficient acetabular coverage around the femoral head, which leads to instability, pain, and injury. Periacetabular osteotomy (PAO) aims to restore acetabular coverage and function, but its effects on capsular mechanics and joint stability are still unclear. The purpose of this study was to examine the effects of PAO on capsular mechanics and joint range of motion in dysplastic hips.

Methods:
Twelve cadaveric dysplastic hips (denuded to bone and capsule) were mounted onto a robotic tester and tested in multiple positions: (1) full extension, (2) neutral 0°, (3) flexion of 30°, (4) flexion of 60°, and (5) flexion of 90°. In each position, the hips underwent internal and external rotation, abduction, and adduction using 5 Nm of torque. Each hip then underwent PAO to reorient the acetabular fragment, preserving the capsular ligaments, and was retested.

Results:
The PAO reduced internal rotation in flexion of 90° (∆IR = –5°; p = 0.003), and increased external rotation in flexion of 60° (∆ER = +7°; p = 0.001) and flexion of 90° (∆ER = +11°; p = 0.001). The PAO also reduced abduction in extension (∆ABD = –10°; p = 0.002), neutral 0° (∆ABD = –7°; p = 0.001), and flexion of 30° (∆ABD = –8°; p = 0.001), but increased adduction in neutral 0° (∆ADD = +9°; p = 0.001), flexion of 30° (∆ADD = +11°; p = 0.002), and flexion of 60° (∆ADD = +11°; p = 0.003).

Conclusions:
PAO caused reductions in hip abduction and internal rotation but greater increases in hip adduction and external rotation. The osseous acetabular structure and capsule both play a role in the balance between joint mobility and stability after PAO.
PRINCIPLES OF ISLAMIC ECONOMIC NORMS IN THE AL-QUR’AN PERSPECTIVE
Authors: Jamarudin Ade , Naisabur Nanang , Naisabur Chikal Anugrah Putra , Akhyar Yundri 
Published: February 2022

Ekonomi Islam adalah ilmu sosial yang mempelajari masalah ekonomi masyarakat yang terinspirasi oleh nilai-nilai Islam. Al- Al-Qur’an tidak hanya membatasi pada orang beriman, tetapi kemanusiaan secara keseluruhan, yang seharusnya tidak terjadi perampasan orang lain dengan cara yang tidak benar (salah). Dengan adanya al-Al-Qur’an sebagai sebuah solusi dan menegaskan bahwa harta dan kekayaan harus didistribusikan secara adil dan merata, tidak boleh berhenti atau berputar di kalangan elit saja. Penelitian ini adalah penelitian kepustakaan (library research) dan bersifat deskriptif, analitik dan komparatif. al-Al-Qur’an telah menawarkan prinsip keadilan dan kesucian pada tiga aspek sekaligus. Ketiga aspek tersebut adalah pertama, melarang pemilikan atau pengelolaan harta yang haram (dzatiyahnya). Kedua, terlarang dalam cara dan proses memperoleh atau mengelola dan mengembangkannya, ketiga, terlarang pada dampak pengelolaan. Keadilan adalah hak individu, kelompok dan golongan. Artinya nilai-nilai kebenaran dan kualitas kebajikan harus diberikan kepada setiap orang. Ketidakadilan ekonomi adalah penyebab perselingkuhan sosial, korupsi dan ketidaksetaraan sosial. Al-Al-Qur’an tidak hanya membatasi kepada orang mukmin tetapi manusia secara keseluruhan, yakni hendaknya jangan terjadi pengambilan hak orang lain dengan cara yang tidak benar. Pengambilan, pengalihan atau pertukaran hak dari seseorang kepada orang lain hendaknya dilakukan dengan cara halal, rela sama rela, tak ada yang rugi dan dirugikan. [Islamic economics is a social science that studies the economic problems of society which are inspired by Islamic values. The Al-Qur’an does not only limit the believers, but humanity as a whole, which should not be deprived of others in an unrighteous (wrong) way. With the existence of the Al-Qur’an as a solution and emphasizing that wealth and wealth must be distributed fairly and evenly, it should not stop or rotate among the elite. This research is a library research and is descriptive, analytic and comparative. al-Al-Qur’an has offered the principles of justice and holiness in three aspects at once. The three aspects are, first, prohibiting the ownership or management of illegal assets. Second, prohibited in the way and process of obtaining or managing and developing it, third, prohibited on the impact of management. Justice is the right of individuals, groups and groups. This means that the values of truth and the quality of virtue must be given to everyone. Economic injustice is a cause of social infidelity, corruption and social inequality. The Al-Qur’an does not only limit the believers but the human being as a whole, that is, there should be no taking of other people's rights in an improper way. Taking, transferring or exchanging rights from one person to another should be carried out in a lawful manner, mutually willing, no one loses or loses.]
CONSUMER BEHAVIOR FOR LKMS-BMT MASLAHAH SIDOGIRI IN PASURUAN: INTERPRETATIVE STRUCTURAL MODELING APPROACH ANALYSIS STUDY
Authors: Parmujianto Parmujianto 
Published: February 2022

Perilaku Konsumen Lembaga Keuangan Mikro Sharia (LKMS)memiliki keunikan tersendiri terkait keputusan pemanfaatan produk jika dikaikan dengan lembaga keuangan sharia dan konvensional. BMT Maslahah (BMTM) Sidogiri Pasuruan merupakan salah satu Lembaga Keuangan Mikro Sharia (LKMS) yang menyediakan jasa keuangan yang berbasis sharia yang tidak lepas dari persepsi dan penilaian calon konsumen yang menggunakan produknya. Mesti secara kuantitatif telah terjadi peningkatan jumlah konsumen, BMT Maslahah belum melakukan identifikasi khusus terkait perilaku audience yang berpotensi menjadi tantangan di masa depan.penelitian ini menggunakan pendekatan kualitatif, yaitu análisis deskriptif dan Interpretative Structural Modeling (ISM). Hasil penelitian menunjukkan bahwa perilaku konsumen BMT Maslahah positif dalam penggunaan produk BMT Maslahah. Pemahaman dan sikap positif terhadap produk BMT Maslahah dilandasi oleh motif kebutuhan sehari-hari dan pengembangan usaha, disamping penerimaan nilai-nilai shariah berupa keberkahan dan keadilan ekonomi saat menggunakan produk BMT Maslahah. Upaya BMT Maslahah Sidogiri Pasuruan dalam membangun perilaku konsumtif kepada konsumen BMT Maslahah dengan mendekatkan pelayanan kepada masyarakat, meningkatkan rasio pengawas dan disiplin pengawasan serta mengembangkan beberapa produk sesuai dengan kebutuhan masyarakat, serta penguatan Sumber Daya Manusia (SDM). [Consumer behavior The Sharia Micro Institution Institution (LKMS) has unique characteristics related to product utilization decision making when it is associated with Islamic and conventional financial institutions. BMT Maslahah (BMTM) Sidogiri Pasuruan is one of the LKMS that provides Sharia-based financial services that cannot be separated from the perceptions and assessments of potential consumers using their products. Even though quantitatively there has been an increase in the number of consumers, BMTM has not made specific identifications related to the behavior of the target audience which could potentially be a challenge in the future. This study uses a qualitative approach, namely descriptive analysis and Interpretative Structural Modeling (ISM). The results showed that consumer behavior in BMTM is positive in the utilization of BMTM products. Understanding and positive attitude towards BMTM products is based on the motives of daily necessities and business development, besides the factors of acceptance of sharia values in the form of blessing and economic justice when using BMTM products. The efforts of BMT Maslahah Sidogiri Pasuruan in building consumer behavior to BMT by bringing services closer to the community, increasing the ratio of supervisors and discipline of supervision and developing several products according to community needs, as well as strengthening human resources.]
VIRUS CORONA DAN DAMPAKNYA TERHADAP PARIWISATA HALAL DUNIA
Authors: Maharani Shinta , Rahman Asmak Ab 
Published: February 2022

Wabah Covid-19menyebabkan dampak kerugian pada berbagai sektor ekonomi termasuk pariwisata halal. Larangan dari berbagai belahan dunia untuk keluar masuk telah menekan sumber pendapatan utama sektor pariwisata. Status waspada virus corona yang dinaikkan dari kuning menjadi merah, yang menandakan penyebaran virus corona sangat serius dan berdampak luas bagi kesehatan masyarakat.Kerugian secara ekonomi ini terjadi karena banyaknya wisatawan dari berbagai negara di dunia yang membatalkan liburan mereka karena takut tertular Covid-19. Hal baru dari paper ini adalah kurangnya penelitian yang mencoba menghubungkan antara dampak virus corona terhadap pariwisata halal. Adapun tujuan dari paper ini adalah: 1. Mendeskripsikan hubungan kausalitas antara virus corona dan dampaknya terhadap pariwisata halal. 2. Meningkatkan efisiensi di sektor pariwisata halal melalui destinasi domestik. 3. Menganalisis dampak virus corona yang menekan pariwisata halal. Metode penelitian ini menggunakan metode kualitatif dan data instrumen yang digunakan adalah data sekunder berupa dokumentasi. Temuan paper ini menunjukkan bahwa virus corona secara signifikan memengaruhi masa depan pariwisata halal di destinasi global, sehingga destinasi domestik adalah solusi dari dampak virus corona untuk mencegah kerugian yang lebih besar pada pariwisata halal. Virus coronavirus menyatukan aktor-aktor utama yang terkait dengan pariwisata halal: medis, kebijakan global dan domestik, akademisi, fasilitas, layanan elektronik, akomodasi dan penerbangan. [The Covid-19 outbreak has a detrimental impact on various economic sectors, including halal tourism. The prohibition from various parts of the world to go in and out has suppressed the main source of income for the tourism sector. The coronavirus alert status has been raised from yellow to red, which indicates the spread of the coronavirus is very serious and has a wide impact on public health. This economic loss occurred because many tourists from various countries in the world canceled their holidays for fear of contracting Covid-19. The novelty of this paper is the lack of research that tries to link the impact of the coronavirus on halal tourism. The objectives of this paper are 1. To describe the causal relationship between the coronavirus and its impact on halal tourism. 2. Increase efficiency in the halal tourism sector through domestic destinations. 3. Analyzing the impact of the coronavirus that suppresses halal tourism. This paper method uses qualitative methods and data used is secondary data in the form of documentation. The findings of this paper indicate that the coronavirus significantly affects the future of halal tourism in global destinations and domestic destinations is a solution to prevent greater losses in halal tourism. The coronavirus brings together the main actors related to halal tourism: medical, global and domestic policy, academia, facilities, electronic services, accommodation, and aviation.]
PENGARUH WAWASAN KEAGAMAAN DAN WAWASAN KEBANGSAAN TERHADAP PERILAKU RELIGIUS DAN PERILAKU SOSIAL SISWA DI SMPN 2 TULUNGAGUNG DAN SMPN 1 KEDUNGWARU (JURNAL PENELITIAN ISLAM
Authors: Riyani Atik , Kholis Nur 
Published: February 2022

Membentuk manusia berkarakter yang baik sangat penting pada zaman modern. Saat ini remaja di Indonesia banyak yang memiliki perilaku buruk, seperti: acuh atak acuh terhadap sesama, ketidak pedulian sesama, permusuhan, hamil diluar nikah, hilangnya sikap sopan santun, kurangnya rasa hormat dan berbagai permasalahan lain. Perilaku adalah bentuk aktivitas manusia, hal tersebut tentu tidak terjadi tanpa adanya pondasi setiap individu, orang yang berwawasan keagamaan dan kebangsaan baik, tentu akan berperilaku baik sesuai dengan wawasan yang dimilikinya. Adapun tata cara riset yang digunakan ialah tata cara kuantitatif dengan metode analisis diskripsi, uji asumsi klasik, product moment serta regresi berganda bantuan IBM SPSS 26. Sampel dalam penelitian ini berjumlah 211 siswa. Instrumen penelitian berupa angket kuesioner, observasi, interview, dan dokumentasi. Tujuan riset ini yakni dapat diketahui pengaruh variabel independen dengan variabel dependen. Kesimpulan dari riset ini bahwa pengaruh wawasan keagamaan memiliki pengaruh sebesar 99,7% dan wawasan kebangsaan memiliki pengaruh sebesar 16,8%. Secara bersamaan terdapat interaksi yang positif dan signifikan antara wawasan keagamaan serta kebangsaan terhadap perilaku religius siswa sebesar 32,04%. [Forming good human character is very important in modern times. Currently, many teenagers in Indonesia have bad behavior, such as: indifferent to others, indifference to others, hostility, pregnancy out of wedlock, loss of manners, lack of respect, and various other problems. Behavior is a form of human activity, this certainly does not happen without the foundation of every individual, people who have good religious and national insight, will certainly behave well according to the insights they have. The research procedure used is a quantitative method with descriptive analysis method, classical assumption test, product-moment, and multiple regression assisted by IBM SPSS 26. The sample in this study amounted to 211 students. The research instruments were in the form of questionnaires, observations, interviews, and documentation. The purpose of this research is to know the influence of the independent variable on the dependent variable. This research concludes that the influence of religious insight influences 99.7% and national insight has an influence of 16.8%. Simultaneously there is a positive and significant interaction between religious insight and nationality on the religious behavior of students by 32.04%.]
Case Report: Adrenalectomy for Primary Hyperaldosteronism; Not the Final Step
Authors: Wazzi-Mkahal Rayyan , Mardini Carla , Joubran Najat I , Khalil Roula Bou 
Published: February 2022

Abstract
Background: Aldosterone-induced glomerular hyper-filtration leads to masked renal dysfunction and profound hypokalemia which will affect the outcome post adrenalectomy. Description of the case: We report a case of a middle-aged man presenting for Primary Aldosteronism, managed by unilateral adrenalectomy, complicated by acute kidney injury and hyperkalemia, treated initially by intravenous hydration and then by Fludrocortisone as maintenance therapy. Patient has noticeably improved. Conclusion: Post-adrenalectomy, the association of acute kidney injury and hyperkalemia in patients with PA is not rare but underestimated. Serum potassium and creatinine must be cautiously monitored in patients with long-term hypertension and kidney disease.
The Falcon Curve: Implications of Seasonal Building Energy Use and Seasonal Energy Storage for Healthy Decarbonization
Authors: Buonocore Jonathan , Salimifard Parichehr , Magavi Zeyneb , Allen Joseph 
Published: February 2022

Abstract
Building electrification is essential to many full-economy decarbonization pathways. Current decarbonization modeling does not incorporate fluctuations in building energy demand. U.S. monthly average total building energy consumption varies by a factor of 1.6x—lowest in May and highest in January. This is largely managed by fossil fuel systems with storage capability. Under all prototypical coefficients of performance (COPs), electrifying buildings substantially increases winter electrical demand, enough to switch the grid from summer to winter peaking. Meeting this with renewables would require a 28x increase in January wind generation, or a 303x increase in January solar, with excess generation in other months. Technologies with a COP of 6 shrink the winter peak—requiring 4.5x more generation from wind and 36x more from solar.
Single-cell evaluation reveals innate immune arrested and lymphocytes shifting that promote development of preinvasive lung adenocarcinoma
Authors: Zhang Chao , Reuben Alexandre , Frank Meredith , Liu Si-Yang , Xie Zhi , Yan Li-Xu , Qiu Zhen-Bin , Hong Hui-Zhao , Su Jian , Tu Hai-Yan , Yang Xue-Ning , Zhang Xu-Chao , Yang Jing-Ji , Zhou Qing , Wu Yi-Long , Zhang Jianjun , Zhong Wen-zhao 
Published: February 2022

Abstract
Cancer immunotherapy has demonstrated promising efficacy in the neoadjuvant setting for treating early-stage non-small cell lung cancer (NSCLC). However, immunotherapy for preinvasive or early invasive disease has been largely overlooked. We performed single-cell RNA and TCR sequencing for 266,804 high quality cells as well as whole exome sequencing (WES) and multiplex immunofluorescence (mIF) on 31 pathologically confirmed preinvasive or early invasive lung adenocarcinoma (LUAD) with paired adjacent tissues. We identified CD47-SIRPA as a key mediator of arresting innate immune response in the tumor microenvironment of preinvasive LUAD. Additionally, highly intercellular heterogeneity was observed and overexpression of KRT18 and PHLDA2 may promote malignant progression during carcinogenesis. By integrating network analysis among tumor and immune cells, we established comprehensive interactive landscape of preinvasive and early invasive LUAD, determining an imbalance of Th17/Treg and increased LAMP3+DCs may boost early tumor development. Our study provides comprehensive genomic and immune features of preinvasive LUAD, highlighting novel therapeutic targets which shed light on understanding how tumor microenvironment shapes neoplastic progression during early evolution of LUAD.
Cross-protection and cross-feeding between ESKAPE pathogens Klebsiella pneumoniae and Acinetobacter baumannii promotes their co-existence
Authors: Semenec Lucie , Cain Amy , Dawson Catherine , Liu Qi , Dinh Hue , Lott Hannah , Penesyan Anahit , Maharjan Ram , Short Francesca , Hassan Karl , Paulsen Ian 
Published: February 2022

Abstract
Acinetobacter baumannii and Klebsiella pneumoniae are opportunistic pathogens frequently co-isolated from polymicrobial infections. The infections where these pathogens co-exist can be more severe and recalcitrant to therapy than infections caused by either species alone, however there is a lack of knowledge on their potential synergistic interactions. In this study we characterised the genomes of A. baumannii and K. pneumoniae strains co-isolated from a single human lung infection. We examined various aspects of their interactions through transcriptomic, phenomic and phenotypic assays that form a basis for understanding their effects on antimicrobial resistance and virulence during co-infection. Using co-culturing and analyses of secreted metabolites, we discovered the ability of K. pneumoniae to cross-feed A. baumannii by-products of sugar fermentation. Minimum inhibitory concentration testing of mono- and co-cultures revealed the ability for A. baumannii to cross-protect K. pneumoniae against the cephalosporin, cefotaxime. Our study demonstrates distinct syntrophic interactions occur between A. baumannii and K. pneumoniae, helping to elucidate the basis for their co-existence in polymicrobial infections.
Does Pollution Levy Standards Reform Promotes Green Innovation? Evidence From China
Authors: Li Zhen , Shen Yanyan 
Published: February 2022

Abstract
Taking advantage of the quasi-natural experiment generated by the adjustment of pollution levy standards in different Chinese provinces and utilizing detailed prefecture-level data from 2004 to 2014, we rigorously examine the effect of the increase in pollution charges on green innovation by adopting the difference-in-differences method. We find that the increase in the pollution levy standards can significantly promote regional green innovation, with the magnitude of being nearly 10%, as compared with their control group. Additionally, we further find that the positive effects tend to be reinforced by financial development and stringent environmental regulations. Particularly, the stimulating effects are mainly reflected in green invention patents, rather than utility model patents. Finally, this reform promotes green innovation in the central region, but has no effect on the eastern and western regions. Our study suggests that Chinese government should set different pollution levy standards for enterprises in different regions, rather than a one-size-fits-all standard.JEL classification H23; O31; Q52; Q58
Association of ALDH1A1 Polymorphism With Toxicity From Cyclophosphamide Treatment
Authors: Hwang Mary , Medley Sarah , Shakeel Faisal , Kidwell Kelley M , Hertz Daniel L 
Published: February 2022

Abstract
Purpose: Cyclophosphamide is a commonly used cancer agent that is metabolically activated by polymorphic enzymes. This study aims to investigate the association between genetic polymorphisms of candidate pharmacogenes with severe toxicity during cyclophosphamide treatment.Methods: Genetic data was collected from an institutional genetic data repository. Genetic polymorphisms in CYP2B6, CYP3A4, CYP2C9, CYP2C19, GSTA1, GSTP1, ALDH1A1, ALDH3A1, ABCC1, ABCB1, and ERCC1 were included in the analysis. Treatment and toxicity data were retrospectively collected from the patient’s medical record. The a priori selected primary hypothesis was that patients who have CYP2B6 reduced metabolizer activity (poor or intermediate metabolizer (PM/IM) vs. other) have higher risk of severe toxicity or cyclophosphamide treatment modification due to toxicity. Results: In the primary analysis of 510 cyclophosphamide-treated patients with available genetic data, there was no difference in the odds of severe toxicity or treatment modification due to toxicity in CYP2B6 PM/IM vs. other (Odds ratio=0.97, 95% Confidence Interval: 0.62-1.50, p=0.88). In an exploratory, statistically uncorrected secondary analysis, carriers of the ALDH1A1 rs8187996 variant had a lower risk of the primary toxicity endpoint compared with wild-type homozygous patients (Odds Ratio=0.31, 95% Confidence Interval: 0.09-0.78, p=0.028). None of the other tested phenotypes or genotypes were associated with the primary or secondary endpoints in unadjusted analysis (all p>0.05).Conclusion: Patients who carry ALDH1A1 rs8187996 may have a lower risk of cyclophosphamide toxicity than wild-type patients. Validation of this associations is necessary to justify development of personalized cyclophosphamide dosing strategies to optimize therapeutic outcomes in patients with cancer.