bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial Intelligence as a Strategic Component of Technological Sovereignty
Authors: Kolianov A. Yu. 
Published: November 2022

Introduction. The article analyzes the scientific, political and social directions of technology development using artificial intelligence in the context of the global digital race. The strategies for achieving technological sovereignty, adopted by the largest countries of the world, and the place and role of artificial intelligence in them are analyzed. Special attention is paid to the analysis of statistical indicators of the achievements of the world's leading states in the field of digital technologies. The scientific, political, economic, regulatory and social resources of the Russian Federation are also being explored, allowing them to become one of the global leaders in digital and technological development.Methodology and sources. The theoretical and methodological base of the study were the classical socio-economic concepts of technological and innovative development (K. Marx, T. Veblein, J. Schumpeter etc.). In the practical part of the study, we used such methods as analysis of documents (reports of the Analytical Center for the Government of the Russian Federation and the Competence Center of the NTI “Artificial Intelligence” of the Moscow Institute of Physics and Technology, analytics from the the Russian International Affairs Council, Oxford Insights, Tortoise etc.) and comparative analysis. The empirical base was data from an analysis of the experience of China, the United States, India and the Russian Federation in developing their own strategies for the development of artificial intelligence technologies.Results and discussion. As a result of the study, we were able to trace how the active actions of the world's largest countries in the conceptualization of steps to develop artificial intelligence are reflected in the construction of the state's technological sovereignty. The analysis made it possible to describe the Russian model of supporting the development of technologies using artificial intelligence as a “Moscow consensus”, characterized by a social orientation of the results.Conclusion. In the structure of technological sovereignty, artificial intelligence plays an important role as a strategic component that contributes to the achievement of digital sovereignty. In the foreseeable future, the critical impact of the dependence of Russia's scientific and technological development on imported solutions and other external factors is obvious, which requires a thorough examination of the situation and a public discussion of any actions for the transition of Russian industry to Industry 4.0. At the same time, it is important to realize that the prospects for technologies using AI are vague without political decisions and financial support.
Organizing Local Messengers: Working Conditions and Barriers to Unionization
Authors: Pupo Norene , Noack Andie 
Published: November 2022

<p>As a result of concerns around declining memberships and the growth of precarious employment in recent years, unions have sought to expand their jurisdictions and organize groups of workers who have typically resisted collective bargaining. Research on union renewal has examined working conditions and workplace structures that may give rise to successful organizing campaigns. In this paper we examine working conditions amongst non-unionized sameday messengers working in Toronto, Canada. The research team conducted 143 semi-structured interviews with bikers, drivers and walkers who work primarily for local courier companies. We find that although same-day couriers are typically treated as ‘independent contractors’, they are dependent on brokers, and precariously employed, with unpredictable income and hours of work. Though this group would benefit substantially from unionization, especially organized on a sector-wide basis, their attitudes and culture combined with the structure of the local industry create substantial impediments to organizing. </p>
"We Are All Alive ... But Dead": Cultural Meanings of War Trauma in the Tamil Diaspora and Implications for Service Delivery
Authors: Kanagaratnam Pushpa , Rummens J Anneke , TonerVA Brenda 
Published: November 2022

<p>Providing culturally appropriate mental health services to war-affected refugees residing in the West continues to pose many challenges. Gaining firsthand knowledge from the refugee communities themselves is crucial to improving our knowledge and guiding our interventions. The purpose of this study is to understand perceptions of war trauma in the Tamil diaspora. Fifty-one Sri Lankan Tamils living in the Greater Toronto Area, Canada, were interviewed. Transcripts were thematically analyzed using content analysis. Findings indicate that war trauma is not viewed by the diaspora as a pathological notion. Positioned within a moral context, and independent from isolated events of war, manifestations of war trauma were discussed at an interpersonal and collective level. Diagnostic categories, including post-traumatic stress disorder (PTSD), do not seem to fully capture the breadth of war trauma in this diaspora community. Implications for service delivery, and for incorporating the unique aspects of suffering resulting from a fragmented community, are discussed.</p>
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A Contemporary Study with Early School Leavers: Pathways and Social Processes of Leaving High School
Authors: Tilleczek Kate , Ferguson Bruce , Edney Dara Roth , Rummens J Anneke , Boydell Katherine , Mueller Michael 
Published: November 2022

<p>This article provides an account and discussion of research processes used in a contemporary study of early school leaving in Ontario, Canada. The Ontario Early School Leavers Study was conducted in conversation with 193 young people who left school prior to graduating, their educators and parents. The study was informed by a review of international literatures which point to the need for innovative social approaches and youth-attuned methodologies in the study of early school leaving. We present our research processes as informed by this literature and then present new analyses that illustrate critical social processes in early school leaving. The findings present unique data to show three pathways to early leaving and a constellation of risk and protective situations encountered by these young people along the way. Risk situations included the daily social workings of poverty, low socioeconomic status, the need to take on early adult roles, “place”, academic and social disengagement, negative relations with families and/or school personnel, and inflexible or unsupportive school structures. Protective situations were encountered in supportive families; from parents and teachers; in schools that were caring, flexible, and proactive; and in processes of self determination. The perspectives of the young people are discussed in relation to the international literature and the perspectives of 71 parents and educators who participated in the study. Impacts on practices in secondary schools suggest that early school leaving be recognized and treated as a heterogeneous, complex social process occurring at and across the nexus of families, schools, youth cultures and communities. </p>
RELEVANSI NILAI INFORMASI AKUNTANSI TERHADAP HARGA SAHAM PADA BEBERAPA PENELITIAN SKRIPSI DAN JURNAL PERGURUAN TINGGI
Authors: Dewi Rachella Chyntia , Adelline Maria Olivia , Krisna Yohanes Aldy , Meiden Carmel 
Published: November 2022

Informasi akuntansi berperan krusial dalam pembentukan pasar modal yang efisien. Pasar modal akan efisien apabila semua informasi yang relevan tercemin pada harga saham. Hasil beberapa riset yang sudah ada sebelumnya terkait relevansi nilai informasi akuntansi terhadap harga saham masih bervariasi dan masih banyak ditemukan pertentangan. Tujuan dari penelitian ini adalah untuk mengintegrasikan hasil penelitian dari beberapa skripsi dan jurnal mahasiswa Perguruan Tinggi terkait relevansi nilai informasi akuntansi terhadap harga saham pada perusahaan di Indonesia. Sampel penelitian ini adalah 18 skripsi maupun jurnal mahasiswa perguruan tinggi. Teknik pengambilan sampel yang digunakan yakni teknik purposive sampling. Teknik analisis data dalam penelitian ini adalah teknik meta-analisis untuk mengintegrasikan hasil penelitian tesis dan menunjukkan kesimpulan terkait relevansi nilai informasi akuntansi terhadap harga saham. Hasil penelitian menunjukan bahwa laba, nilai buku ekuitas, dan arus kas operasi memiliki relevansi nilai terhadap harga saham dengan korelasi lemah. Sedangkan, leverage tidak mempunyairelevansi nilai terhadap harga saham.
Comparison of two acidophilic sulfidogenic consortia for the treatment of acidic mine water
Authors: Frederico Tayná Diniz , Nancucheo Ivan , Santos Werica Colaço Barros , Oliveira Renato Renison Moreira , Buzzi Daniella Cardoso , Pires Eder Soares , Silva Patricia Magalhães Pereira , Lucheta Adriano Reis , Alves Joner Oliveira , Oliveira Guilherme Corrêa de , Bitencourt José Augusto Pires 
Published: November 2022

Sulfate-reducing bioreactors are a biotechnological alternative for the treatment of acid mine drainage (AMD). In this study, two separate bioreactors with pH and temperature-controlled (Bio I and II) were operated with two different acidophilic microbial consortia to determine their efficiencies in sulfate removal from a synthetic acidic mine water. The bioreactors were operated for 302 days in continuous flow mode under the same parameters: fed with a sulfate solution of ∼30 mM with a pH of 2.5, the temperature at 30°C, stirred gently at 40 rpm and using a continuous stream of nitrogen to help remove the H2S produced in the bioreactor. The glycerol consumption, acetate production, and sulfate removal were monitored throughout the course of the experiment. The community composition and potential metabolic functional groups were analyzed via 16S rRNA partial gene sequencing. Bio I consortium reduced the sulfate, achieving a range of sulfate concentration from 4.7 to 19 mM in the effluent liquor. The removal of sulfate in Bio II was between 5.6 and 18 mM. Both bioreactors’ communities showed the presence of the genus Desulfosporosinus as the main sulfate-reducing bacteria (SRB). Despite differences in microbial composition, both bioreactors have similar potential metabolism, with a higher percentage of microorganisms that can use sulfate in respiration. Overall, both bioreactors showed similar performance in treating acidic mine water containing mostly sulfate using two different acidophilic sulfidogenic consortia obtained from different global locations.
Interaction of haemin with albumin-based macroporous cryogel: Adsorption isotherm and fluorescence quenching studies
Authors: Hajizadeh Solmaz , Dicko Cedric , Bülow Leif 
Published: November 2022

Albumin-based cryogels for capturing haemin were synthesised by crosslinking different biomolecules, bovine serum albumin (BSA) and ovalbumin (OVA). The impact of the protein and coupling agent concentrations on cryogel’s mechanical properties, swelling ratios and polymerisation yields, as well as autoclaving as a post-treatment on the cryogel, were studied. We found that BSA (50 mg/ml) and the crosslinker (N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride, 46 mg/ml) formed a cryogel with optimum physical characteristics at a comparatively low protein concentration. The cryogel’s mechanical stability was increased using a double-layer cryogel approach by crosslinking the BSA proteins at subzero temperature inside an acrylamide and hydroxyethyl methacrylate premade cryogels. Batch binding and kinetic adsorption isotherms of haemin on the cryogels were assessed to evaluate their binding capacity toward the porphyrin molecule. The results showed that single-layer cryogels (BSA and OVA) had a higher capacity (∼0.68 mg/ml gel) and higher reaction rate constant towards haemin adsorption than double-layer gels. In contrast, the double-layer cryogels had higher mechanical strength than single-layer gels. The experimental results suggested that the cryogels followed the Freundlich model and the pseudo-second-order isotherm for batch adsorption and kinetics, respectively. The interaction between haemin and the gels was studied by fluorescence quenching. We found between 1.1 and 1.6 binding sites for different cryogels.
Development of an in vitro model to estimate mass transfer from the anterior cavity
Authors: Liu Tianyang , Ibeanu Nkiruka , Brocchini Steve , Khaw Peng Tee , Bouremel Yann , Awwad Sahar 
Published: November 2022

Knowledge of drug mass transfer from the anterior chamber via the iris-lens barrier has important implications for the development of front of the eye medicines that can also deliver drugs to the vitreous cavity. Here, the design and evaluation of a novel in vitro model that estimates anterior clearance (CL) kinetics is described. To mimic some aspects of the human eye to aid with pharmaceutical modelling, the model incorporated a simulation of aqueous inflow from the ciliary inlet at the physiological flow rate, two CL elimination pathways [anterior hyaloid pathway and retina choroid sclera (RCS) pathway], human cavity dimensions and use of simulated vitreous fluid (SVF). An eye movement platform that incorporated 3 different eye movements (smooth pursuit, microsaccadic and saccadic) was tested against the control (no movement) to observe any difference in anterior kinetics profile and drug convection to the posterior cavity. Both timolol and brimonidine injected in the intracameral space were evaluated in the new in vitro prototype. An initial release study with one selected eye movement (smooth pursuit) with timolol (6.8 ± 0.4 µg, 30 μL) and brimonidine (15.3 ± 1.5 µg, 30 μL) showed half-life values of 105.3 and 97.8 min respectively in the anterior cavity (AC) space. Another study evaluated the effect of all eye movements against control with both drugs with higher doses of timolol (146.0 ± 39.1 μg, 25 μL) and brimonidine (134.5 ± 39.5 μg, 25 μL). The amounts of timolol in the back of the eye (RCS membrane and outflow) were 0.07 ± 0.05%, 1.36 ± 0.88%, 1.55 ± 1.03% and 0.98 ± 0.06% by 8 h with smooth pursuit, microsaccadic, saccadic and no movement respectively; whereas brimonidine amounts were 0.70 ± 0.21%, 0.94 ± 0.40%, 1.48 ± 1.02%, and 0.76 ± 0.33% respectively. A small amount of both drugs was seen in other compartments in the model (lens part, iris part, hyaloid membrane part and silicone cornea). These results indicate that this model can be used to determine transfer of small molecules via the iris-lens barrier to help optimise front of the eye formulations to treat tissues further back in the eye.
Sperm-carried IGF2 downregulated the expression of mitogens produced by Sertoli cells: A paracrine mechanism for regulating spermatogenesis?
Authors: Cannarella Rossella , Mancuso Francesca , Arato Iva , Lilli Cinzia , Bellucci Catia , Gargaro Marco , Curto Roberto , Aglietti Maria C. , La Vignera Sandro , Condorelli Rosita A. , Luca Giovani , Calogero Aldo E. 
Published: November 2022

IntroductionInsulin-like growth factor 2 (IGF2) mRNA has been found in human and mouse spermatozoa. It is currently unknown whether the IGF2 protein is expressed in human spermatozoa and, if so, its possible role in the cross-talk between germ and Sertoli cells (SCs) during spermatogenesis.MethodsTo accomplish this, we analyzed sperm samples from four consecutive Caucasian men. Furthermore, to understand its role during the spermatogenetic process, porcine SCs were incubated with increasing concentrations (0.33, 3.33, and 10 ng/mL) of recombinant human IGF2 (rhIGF2) for 48 hours. Subsequently, the experiments were repeated by pre-incubating SCs with the non-competitive insulin-like growth factor 1 receptor (IGF1R) inhibitor NVP-AEW541. The following outcomes were evaluated: 1) Gene expression of the glial cell-line derived neurotrophic factor (GDNF), fibroblast growth factor 2 (FGF2), and stem cell factor (SCF) mitogens; 2) gene and protein expression of follicle-stimulating hormone receptor (FSHR), anti-Müllerian hormone (AMH), and inhibin B; 3) SC proliferation.ResultsWe found that the IGF2 protein was present in each of the sperm samples. IGF2 appeared as a cytoplasmic protein localized in the equatorial and post-acrosomal segment and with a varying degree of expression in each cell. In SCs, IGF2 significantly downregulated GDNF gene expression in a concentration-dependent manner. FGF2 and SCF were downregulated only by the highest concentration of IGF2. Similarly, IGF2 downregulated the FSHR gene and FSHR, AMH, and inhibin B protein expression. Finally, IGF2 significantly suppressed the SC proliferation rate. All these findings were reversed by pre-incubation with NVP-AEW541, suggesting an effect mediated by the interaction of IGF2 with the IGFR.ConclusionIn conclusion, sperm IGF2 seems to downregulate the expression of mitogens, which are known to be physiologically released by the SCs to promote gonocyte proliferation and spermatogonial fate adoption. These findings suggest the presence of paracrine regulatory mechanisms acting on the seminiferous epithelium during spermatogenesis, by which germ cells can influence the amount of mitogens released by the SCs, their sensitivity to FSH, and their rate of proliferation.
Role of cytotoxic T cells and PD-1 immune checkpoint pathway in papillary thyroid carcinoma
Authors: Banerjee Sohini , Nahar Uma , Dahiya Divya , Mukherjee Soham , Dey Pranab , Gupta Rijuneeta , Radotra Bishan , Sachdeva Naresh , Sood Ashwani , Bhadada Sanjay Kumar , Bhansali Anil 
Published: November 2022

BackgroundLymphocytic thyroiditis (LT) is frequently seen in the tumor microenvironment (TME) of papillary thyroid carcinomas (PTCs). However, the characteristic of these tumor-infiltrating lymphocytes (TILs) is not well understood.ObjectiveWe aim to define the TME of PTC cases by characterizing the TILs.DesignThis is a cross-sectional observational study.PatientsWe enrolled 29 PTC (23 having concurrent LT), 14 LT, and 13 hyperplastic nodules with LT (HN) patients from January 2016 to December 2020.MeasurementsImmunohistochemical (IHC) expression of CD8, FoxP3, PD-1, and PD-L1 was studied in PTC with LT and compared with HN. PD-1 and PD-L1 expression was correlated at the mRNA level by quantitative real-time PCR. Immunophenotyping of TILs was done in FNAC samples of PTC and LT by flow cytometry.ResultsIHC revealed the presence of CD8+ cytotoxic T lymphocytes (CTLs) and FoxP3+ T regulatory cells (Tregs) in 83% and 52% of PTC with LT cases, respectively. Flow cytometric analysis of the PTC samples revealed a significant abundance of CTL compared with Treg and a higher CTL with lower Treg counts compared with LT. On IHC, PD-1 positivity was noted in 56.5% of PTC with LT cases, while intermediate PD-L1 positivity was found in 70% of the cases. There was a significant upregulation of PD-1 mRNA in PTC with LT. A significant correlation was noted with PD-L1 expression with lymph node metastasis and presence of Treg cells.ConclusionsIncreased expression of PD-1 and PD-L1 in the TME of PTC may provide a potential molecular mechanism for tumor survival despite the predominance of CTLs, possibly through their inactivation or exhaustion.
Sea surface temperature retrieval based on simulated space-borne one-dimensional multifrequency synthetic aperture microwave radiometry
Authors: Guo Chaogang , Ai Weihua , Liu Maohong , Feng Mengyan , Qiao Junqi , Hu Shensen 
Published: November 2022

The space-borne one-dimensional multifrequency synthetic aperture microwave radiometer (1D-MSAMR) offers new possibilities for detecting high spatial resolution sea surface temperature (SST). To achieve higher SST retrieval accuracy, an SST retrieval algorithm, the two-step retrieval algorithm (TSSR), is proposed based on the multiple linear regression (MLR) algorithm. In this study, we investigated the SST retrieval accuracy of 1D-MSAMR based on simulation experiments. For the study, we assumed that the frequencies of the 1D-MSAMR were 6.9, 10.65, 18.7, 23.8, and 36.5 GHz, and that all frequencies worked in a dual polarization (vertical and horizontal) manner. We used an ocean-atmosphere microwave radiation brightness temperature model and the 1D-MSAMR simulator to simulate the measured brightness temperature based on WindSat data provided by the Remote Sensing Systems (RSS). An MLR algorithm and the TSSR were then developed to retrieve the SST within the incidence angle range of 0°–65°. The results show that the SST retrieval errors of the two SST retrieval algorithms decreased with the increase of incidence angle. The TSSR had higher retrieval accuracy, especially at low incidence angle. The average retrieval accuracy of the TSSR was about 0.3 K higher than that of the MLR algorithm. The retrieval error of the TSSR was also less sensitive to the measurement error of the 6.9 GHz frequency than the MLR algorithm.
Development and validation of a system for the prediction of challenging behaviors of people with autism spectrum disorder based on a smart wearable shirt: A mixed-methods design
Authors: Zwilling Moti , Romano Alberto , Hoffman Hay , Lotan Meir , Tesler Riki 
Published: November 2022

BackgroundMost people with autism spectrum disorder (ASD) present at least one form of challenging behavior (CB), causing reduced life quality, social interactions, and community-based service inclusion.ObjectivesThe current study had two objectives: (1) to assess the differences in physiological reaction to stressful stimuli between adults with and without high-functioning ASD; (2) to develop a system able to predict the incoming occurrence of a challenging behaviors (CBs) in real time and inform the caregiver that a CB is about to occur; (3) to evaluate the acceptability and usefulness of the developed system for users with ASD and their caregivers.MethodsComparison between physiological parameters will be conducted by enrolling two groups of 20 participants with and without ASD monitored while watching a relaxing and disturbing video. To understand the variations of the parameters that occur before the CB takes place, 10 participants with ASD who have aggressive or disruptive CBs will be monitored for 7 days. Then, an ML algorithm capable of predicting immediate CB occurrence based on physiological parameter variations is about to be developed. After developing the application-based algorithm, an efficient proof of concept (POC) will be carried out on one participant with ASD and CB. A focus group, including health professionals, will test the POC to identify the strengths and weaknesses of the developed system.ResultsHigher stress level is anticipated in the group of people with ASD looking at the disturbing video than in the typically developed peers. From the obtained data, the developed algorithm is used to predict CBs that are about to occur in the upcoming 1 min. A high level of satisfaction with the proposed technology and useful consideration for further developments are expected to emerge from the focus group.Clinical trial registration[https://clinicaltrials.gov/], identifier [NCT05340608].