bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early exposure to enriched environment protects apoptosis and improves behavioral improvement by downregulating Fas/FasL signaling pathway after hypoxic-ischemic brain injury
Authors: Cho Sung-Rae , Lee Hoo Young , Song Suk-Young , Hwang Jihye , Baek Ahreum , Kim Sung Hoon , Park Jung Hyun , Pyo Soonil 
Published: April 2022

Abstract
Early rehabilitation presents favorable outcomes for stroke patients. However, the optimal strategy for early rehabilitation is unclear currently due to the current limitation in the data on the effects of early initiation of rehabilitation based on voluntary exercise. During the hyperacute phase of ischemic stroke, upregulation of Fas/FasL-mediated apoptosis is observed. Environmental enrichment (EE) is a therapeutic paradigm for laboratory animals that consists of complex combinations of physical, cognitive, social stimuli and voluntary exercise. Few studies delineated the effect of EE on apoptosis in an experimental model of hyperacute stroke. The aim of the study is to determine whether hyperacute exposure to EE can effectively regulate Fas/FasL-mediated apoptosis following hypoxic-ischemic brain injury and improve neurobehavioral function. C57Bl/6 mice were randomly assigned to either EE or standard cage (SC) within 3 hours or on day 3 after hypoxic-ischemic brain injury for 2 weeks. Neurobehavioral tests, transcriptome analysis, Western Blot, and immunohistochemistry were performed in the brain samples of cerebral cortex and hippocampus, and total infarct volume was calculated. Compared with SC, hyperacute exposure to EE was associated with greater improvement in anxiety, motor function, cognitive ability, reduced total infarct volume, and decreased neuronal death. It significantly downregulated Fas/FasL-mediated apoptosis, decreased expression of Fas, FADD, cleaved caspase-8/caspase-8, cleaved caspase-3/caspase-3, as well as Bax/Bcl-2 in both regions. Overall, the results of this study demonstrates that the early exposure to EE is a neuroprotective therapeutic translation for stroke rehabilitation through effective inhibition of extrinsic as well as intrinsic apoptotic pathways.
Observation of Curative Effect on Meridian Theory-based Extracorporeal Shock Wave Therapy for Non-specific Low Back Pain: Study Protocol for a Randomized Controlled Trial
Authors: 凡 勇福 , Liu Feilai , Li Mengna , 阮 晓迪 , Wu Mingli , 苏 凯奇 , Gao Jing , Feng Xiaodong 
Published: April 2022

Abstract
Background
Non-specific low back pain (NLBP) is a major global socioeconomic burden, and the prevalence of NLBP is still on the rise. At present, there is no ideal cure effect of drugs for this disease. This may be the reason why patients often use complementary therapies. Among them, extracorporeal shock wave therapy (ESWT) has gradually received more attention and has become the main treatment method for NLBP. The purpose of this study is to provide scientific evidence for the effect and safety of meridian theory-based ESWT on NLBP.
Objective
This study aims to evaluate the effect and safety of meridian theory-based ESWT on NLBP. This study will also provide more high-quality experimental evidence for the clinical application of meridian theory-based ESWT for the treatment of NLBP in the future.
Methods
This study is a single-blind, multi-center, randomized controlled trial. 64 patients with NLBP, aged 18 to 60 years, will randomly divided into two groups: the experimental group(N.=32), which will receive meridian theory-based ESWT application, and the control group(N.=32) which will receive conventional ESWT treatment. These two applications will be carried out twice a week for two weeks. The primary outcomes will be Visual Analog Scale (VAS) and Oswestry Disability Index (ODI). The secondary outcome will be Surface Electromyography (sEMG). All outcomes will be evaluated at baseline and after the intervention (7 days, 14 days).
Discussion
The results of this multi-center randomised controlled trial will contribute to providing rigorous clinical evidence for the efficacy and security of meridian theory-based ESWT for NLBP.
Trial registration:
Chinese Clinical Trial Registry, ChiCTR2100051049. Registered on 10 September 2021, http://www.chictr.org.cn/showproj.aspx?proj=46316
EFFECT OF THE THIRD DOSE OF ASTRAZENECA VACCINE ON THE ABILITY TO GENERATE ANTI-RBD ANTIBODIES WITHIN TWO AT-RISK POPULATIONS, GERIATRICS AND HEALTH PERSONNEL IN THE PROVINCE OF TUCUMÁN
Authors: Ruiz Luis Medina , Contreras Miguel Ferre , Molina Eliana , Aguilar Mónica , Costas Dardo , Aznar Patricia , Alcorta María Elena , Lara Laura , Barrenechea Guillermo Gabriel , Ortega Eugenia Silvana , Peral María de los Ángeles 
Published: April 2022

Abstract
This study aims to evaluate the effect on the ability to generate Anti-Anti RBD antibodies (Anti-SAR-CoV 2-Spike-RBD) to the third dose of the AstraZeneca vaccine in two at-risk populations in the Province of Tucumán. Humoral immune responses, assayed by anti-SARS-CoV-2-Spike-RBD IgG ELISA, were measured in 223 participants, including geriatric patients and healthcare workers, at 0, 14 and 28 days after receiving third dose of the AstraZeneca between October and December 2021 in Tucuman, Argentina. The antibodies title in geriatric patients with and without previous COVID-19 diseases and complete vaccine schedule increased significantly 14 days after receiving the third dose of the AstraZeneca vaccine (p<0.001). When compared Antibody Concentration in geriatric patients with and without a history of COVID-19 14 days post-vaccination, the increase in antibodies was higher in those who did not have a previous history of COVID-19 (p<0.05). The antibodies title in healthcare personnel with and without previous COVID-19 diseases and complete vaccination increased significantly 14 days post-vaccination with the third dose of AstraZeneca (p<0.01). There was a negative correlation between age and antibodies titer 14 days after the third dose of COVID vaccine in persons with no history of disease (rs= -0.36, p=0.0001). While persons with a history of COVID-19 did not have a significant correlation (rs= -0.03; p=0.8). The results obtained provide information on antibodies dynamics after the third dose with AstraZeneca in a context of vaccine heterogeneity, indicating the importance of baseline studies of antibodies and hybrid immunity when considering vaccination policies.
Constructing an adaptability evaluation framework for community disaster management from an earthquake event
Authors: Lin Bih-Chuan , Lee Chun-Hung 
Published: April 2022

Abstract
The frequency and intensity of natural disasters continue to increase with climate change, especially earthquake disasters, causing community in the serious damage and casualties. How to improve community awareness and adaptability to disasters is key point for policymakers, because each community may bring different perspectives to understanding community disaster adaptive and resilience. Based on the aspects of adaptive capacity and community resilience, we adopting the choice experiment (CE) to assess the disaster prevention preferences of urban and suburban residents to establish an adaptive evaluation framework for community disaster management. The results show features that affect the differentiation of community residents' participation regarding community disaster management program are : 1) to have a regularly disaster prevention drills, 2) to cooperate drills with local governments, 3) to train to become a disaster prevention vanguard, and 4) to assemble NGOs and government forces to respond for disaster-occurring. The scenario of integrated disaster prevention educations and community organization transformation has the highest welfare effects among all the proposed scenarios; And only if the disaster prevention management preference and disaster perception ability of community residents are applied to the disaster prevention strategy, so that disaster management can be effectively implemented in the community. These findings provide useful theoretical construction and policy inspiration for the government in the development of disaster management and community disaster management organizations.
Genomic analyses identify critical significant biological processes in prunetin treated gastric cancer cells
Authors: Wang Mengshan , Chang Tingxiang 
Published: April 2022

Abstract
Gastric cancer is a malignant tumor in the digestive system and surgery is the only radical treatment. Prunetin is a kind of O-methylated flavonoid that belongs to the group of isoflavone executing beneficial activities, which recently showed treatment effects on a variety of cancers. However, the mechanism of prunetin in gastric cancer is still unclear. Here, we aim to discover the key genes and signaling pathways by analyzing the RNA-seq data. The GSE198930 was created by the Illumina NovaSeq 6000 (Homo sapiens). The KEGG and GO analyses revealed that "Biosynthesis of cofactors" and "Carbon metabolism" were the main changed biological processes. Moreover, we revealed several interactive genes including MYC, SRC, ASNS, SHMT2, PSAT1, CXCL8, EIF4EBP1, PSPH, SLC1A5, and MTHFD2. Our study may provide novel insights into the treatment of gastric cancer.
Impact of Sugarcane outgrower Scheme on Income of Participating Households: empirical evidence around Wonji/Shoa Sugar Factory, Ethiopia
Authors: FEDI GUTEMA BATI , Asefa Fekadu Dereje , Waktola Abebe Tafa 
Published: April 2022

Abstract
Abstract

Contract farming has been practiced in the sugarcane outgrowers scheme at Wonji/Shoa sugar factory more than two decade. However, their economic impact of participating farmers is remains underexplored. The study, is therefore, analyzed the impact of sugarcane outgrower scheme on participant households by comparing with non contract farm households around Wonji/Shoa sugar factory area. The propensity score matching and probit model was used to estimate scheme impact on income and determine factors influencing participation, respectively. The probit model result show that age, total farm area and distance of the farm area from sugar factory weigh bridge/main road have positively and statistically effects participation where as farming experience and livestock asset holding have negatively and statistically influenced farmers’ participation. The propensity score matching estimates show that compared with their non-participant counterparts, participation in sugarcane outgrower scheme farming is associated with less beneficial effects in proxy measures of the average farm household's farm income per adult equivalent with statistically significant at 1% probability level. In conclusion, finding stress the need for appropriate policy formulation and implementation on improving the farm households’ income of participants which economically benefits contract smallholder farmers. These may include improving the productivity and efficiency of sugarcane production, optimizing cost of production, encouraging the scheme farmers to diversify their livelihoods, improving the price of sugarcane output per tonnage, and additional support by third parties.

Keywords : Outgrower scheme, Sugarcane, Wonji/Shoa, farm household income, Oromia, Ethiopia
The use of targeted therapy lumacaftor/ivacaftor in patients with cystic fibrosis
Authors: Chermensky A. G. , Gembitskaya T. E. , Orlov A. V. , Makhmutova V. R. 
Published: April 2022

Accepted, basic therapy of cystic fibrosis (CF), until recently, was symptomatic and aimed at slowing down pathological processes, mainly from the respiratory system and gastrointestinal tract, caused by a defect in the CFTR gene. New strategic opportunities have emerged since 2012 and are aimed at correcting a defect in a gene or its product. A mutation in the cystic fibrosis gene disrupts the function of the cystic fibrosis transmembrane conductance regulator protein (CFTR or CFTR in English transcription), which is located on the surface of the apical membrane of epithelial cells and functions as a chloride channel. The basic achievement for the new CF therapy was the discovery of small molecules that restore the processes of synthesis, transport to the membrane, or the functioning of the defective CFTR protein. The effectiveness of drugs that restore CFTR function is related to the ability of the molecules to deliver an adequate amount of the CFTR protein to the surface of the epithelial cell and/or improve its functional activity. Among them, correctors and potentiators for pharmacological modulation of ion transport are distinguished in clinical practice. Correctors are medicinal substances that allow the mutant CFTR protein to pass through the system of intracellular quality control and take the correct location on the apical membrane (with class II mutations). The action of potentiators is aimed at restoring (activating) the function of the ion channel formed by the mutant CFTR protein (class III–IV mutations). The purpose of this article is to analyze the literature sources, the results of clinical trials on the use of CFTR modulators, including combinations of a potentiator and a corrector. Their effectiveness and safety were evaluated. Literature sources (20) are used and own clinical observation is given. A positive assessment of the action of the modulator, the combination of a potentiator and a corrector, its safety and good tolerability is given. In conclusion, the place and indications for prescribing drugs of this class, the number of patients in the Russian Federation in need of such treatment are determined.
A SEXUALIDADE EM TEMPOS DE COVID-19: O USO DE MÍDIAS SOCIAIS POR HOMOSSEXUAIS NA PANDEMIA
Authors: Bortolozzi Ana Cláudia , Mendes Cordeiro Caique , Spadotto de Carvalho Leilane Raquel 
Published: April 2022

Diante da pandemia do COVID-19, muitos problemas na saúde mental e nos relacionamentos afetivos e sexuais surgiram em decorrência das ações para a prevenção e o controle da doença. A chamada “quarentena” impôs às pessoas uma vida de isolamento social com restrições de contatos com amigos, parentes e vínculos amorosos estáveis ou não. O público homossexual ainda costuma esconder a expressão de seus desejos e vínculos eróticos em uma sociedade preconceituosa, utilizando-se de mídias sociais como alternativas para a busca de parceiros e encontros. Este estudo teve por objetivo investigar a opinião de 72 pessoas homossexuais ou bissexuais sobre o uso de mídias digitais para relacionamentos afetivos e sexuais antes e durante o período de isolamento, devido a prevenção ao contágio do COVID-19, que responderam a um questionário on line, para análise quantitativa. Os resultados mostram que a maioria dos/as entrevistados/as afirmou que os relacionamentos antes da pandemia mantiveram-se e houve um aumento da utilização das mídias sociais com seus parceiros/as com fins sexuais. Antes da pandemia o motivo principal do uso de aplicativos de relacionamentos era o de “marcar encontros”, mudando em tal período para a função de “ter com quem falar” ou deixaram de ser usados. Conclui-se que o público LGBTQ+ vivencia maior vulnerabilidade sexual e afetiva no período de isolamento social e profissionais da área da saúde mental devem oferecer mais atenção para essa população.
Effective dilution rate to suppress the risk of Microcystis blooms in Lake Tega, Japan, based on a competitive growth simulation model
Authors: Li Jingnan , Chujo Masato , Amano Yoshimasa , Machida Motoi 
Published: April 2022

Abstract
Although water transfer as an efficient method to improve water quality and control Microcystis blooms in lakes has been executed for several decades, few studies have examined effective dilution rates depending on various water qualities. Therefore, to clarify the effective dilution rate to suppress Microcystis blooms, a competitive growth simulation model developed for eutrophic conditions was utilized. A competition experiment between Microcystis sp. and Cyclotella meneghiniana under limited phosphorus and sufficient nitrogen concentration was conducted to investigate the mechanism of dilution effect and verify the broad applicability of the simulation model. Experimental results revealed that there was no remarkable discrepancy in Microcystis sp. cell density among different dilution groups (p&gt;0.05), while C. meneghiniana cell density was significantly different between groups (p&lt;0.05). The accuracy of the simulation model under limited phosphorus as well as sufficient nitrogen concentration was verified by comparing the simulated value with experimental results. Based on the simulated results, it was suggested that a dilution rate of over 13.3% can suppress Microcystis blooms effectively in Lake Tega, Japan, as a case study. The predicted data was also compared with the field data collected over years in Lake Tega, and its effectiveness has been confirmed.
Linguística Funcional Centrada no Uso: teoria, método e aplicação
Authors: Bispo Edvaldo Balduino , Guimarães Lopes Monclar 
Published: April 2022

Neste texto, apresentamos o número especial 2022 da Revista Odisseia, organizado para abrigar trabalhos voltados para as mais recentes tendências de pesquisa na área da Linguística Funcional Centrada no Uso. De início, partimos da contextualização dessa perspectiva linguística no cenário acadêmico brasileiro, explicitando sucintamente seus pressupostos teóricos e categorias analíticas. Contemplamos aspectos de ordem conceitual e metodológica com que pesquisadores funcionalistas passaram a lidar devido à incorporação de postulados e conceitos operacionais da Gramática de Construções. Por fim, descrevemos os trabalhos que compõem este dossiê, os quais se voltam tanto para a reflexão e/ou a discussão de questões teóricas e metodológicas quanto para a aplicação desse viés funcionalista à descrição e à análise do português.
Role of Serum Cystatin C as a Diagnostic Tool for Renal Function in Cirrhotic Patients
Authors: Asal Fathia Elsayed , Yousef Mohamed , Abdraboh Hend Atteya Abdelkhalek , Abd-Elsalam Sherief , Abdelaziz Shama Ahmed Abdelaziz , Elbahnasawy Mohamed , Elnaggar Mohammed H , Alsrogy Hesham Ahmed , Elashry Heba 
Published: April 2022

Background:
Assessment of cystatin C levels could be valuable in the early detection of renal dysfunction because they increase faster than the creatinine levels as the GFR decreases. The aim of this work was to evaluate serum cystatin C as a diagnostic tool for renal dysfunction in cirrhotic patients with and without hepatorenal syndrome (HRS).

Methods:
This case-control study was conducted on 60 patients from the Tropical Medicine Department of Tanta University Hospitals and 10 people served as healthy control volunteers. Serum cystatin C was measured in the three groups.

Results:
A significant difference was observed among the three groups as cystatin C was higher in patients with HRS compared to the cirrhotic group and healthy controls.

Conclusion:
Serum cystatin C is a good predictor for hepatorenal syndrome with a good correlation with serum creatinine, blood urea, GFR, and creatinine clearance.
Comparative Clinical Study of Hijama bil shart (Wet Cupping) and Hijama bil nar (Fire Cupping) in Irq al- nasa’ (Sciatica)
Authors: Aziz Abdul , Rather Shameem Ahmad , Bhat Shabir Ahmad 
Published: April 2022

Background: ‘Irq al nasa’ an Arabic term to which we call ‘Sciatica’ is clinically defined as the pain along with Sciatic nerve and its component nerve roots. Pain may vary from mild ache to severe burning or shooting, or tingling in nature. According to Unani literature, sciatica (Irq al-nasa') may be caused by accumulation of morbid matter or phlegm (Khilt balgham galeez) in the affected area. “Hijama” means “to suck” is a Unani regimental method of treatment, which helps to evacuate the morbid materials from the body and reassure the blood flow to the site of Hijama.
Objective: This study aims to compare the efficacy and safety of hijama bil-shart (wet cupping) and hijama bil-nar (fire cupping) in the management of sciatica.
Methods: In an open, randomized, controlled study out of 70 sciatica patients, 60 were randomly allocated in test and control group, 30 in each. The test group received wet cupping and control group were applied with fire cupping at 0th, 15th, 30th and 45th day.
Results: While observation of visual analogue scale for pain, limb movement, straight leg raising test, deep tendon reflexes at ankle and knee joint, and stiffness along with Bragard’s sign, the intergroup comparison of pre and post treatment results showed wet cupping is more effective than fire cupping (p<0.001).
Conclusion: Hijama bil-shart (wet cupping) is more effective than hijama bil-nar (fire cupping) in managing sciatica. Both the therapies were generally well tolerated.
Keywords: Cupping, Hijama, Sciatica, Unani.
Relationship of Knowledge in Women Age 25-50 Years in RW 05 Cibubur, East Jakarta on BSE Knowledge as Early Detection of Breast Cancer
Authors: Suryanegara Wiradi , Gultom Fajar Lamhot 
Published: April 2022

In Indonesia, based on Indonesia’s Health Profile 2008, the top 10 major malignant neoplasm disease or cancer inpatients at the hospital since 2004-2008 has not changed much. The first rating is breast malignant neoplasm or breast cancer. Society rarely knows that it is important to perform BSE (breast self-examination) early, which can help reduce the incidence of morbidity or mortality of breast cancer patients. The purpose of this study was to determine the relationship between knowledge in women aged 25-50 years at RW 05 Cibubur, East Jakarta, on BSE as early detection of breast cancer. This research employed an analytic survey with the cross-sectional approach. The employed technique in sampling was simple random sampling. It was done with the lottery technique to population members. The results of the 207 respondents showed that respondents with bad BSE knowledge were 100 people (48.3%) and respondents with good knowledge were 107 (51.7%). The respondents who practiced the BSE were 95 (45.9%), and the respondents who did not were 112 people (54.1%). The statistical test results had a very strong correlation with the value of 0.832 and correlated with the statistical value of 0.000.
Keywords: Breast Cancer, Knowledge, BSE (Breast Self-Examination), Women Aged 25-50 Years at RW 05 Cibubur East Jakarta.