bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flow similarity, stochastic branching, and quarter-power scaling in plants
Authors: Price Charles A , Drake Paul , Veneklaas Erik J , Renton Michael 
Published: August 2022

Abstract
The origin of allometric scaling patterns that are multiples of one-fourth has long fascinated biologists. While not universal, quarter-power scaling relationships are common and have been described in all major clades. Several models have been advanced to explain the origin of such patterns, but questions regarding the discordance between model predictions and empirical data have limited their widespread acceptance. Notable among these is a fractal branching model that predicts power-law scaling of both metabolism and physical dimensions. While a power law is a useful first approximation to some data sets, nonlinear data compilations suggest the possibility of alternative mechanisms. Here, we show that quarter-power scaling can be derived using only the preservation of volume flow rate and velocity as model constraints. Applying our model to land plants, we show that incorporating biomechanical principles and allowing different parts of plant branching networks to be optimized to serve different functions predicts nonlinearity in allometric relationships and helps explain why interspecific scaling exponents covary along a fractal continuum. We also demonstrate that while branching may be a stochastic process, due to the conservation of volume, data may still be consistent with the expectations for a fractal network when one examines sub-trees within a tree. Data from numerous sources at the level of plant shoots, stems, and petioles show strong agreement with our model predictions. This theoretical framework provides an easily testable alternative to current general models of plant metabolic allometry.
Ultrasonography in the prediction of gout flares: a 12-month prospective observational study
Authors: Cipolletta Edoardo , Abhishek Abhishek , Di Battista Jacopo , Grassi Walter , Filippucci Emilio 
Published: August 2022

AbstractObjectivesTo evaluate whether US findings indicating MSU deposits and US-detected inflammation (i.e. power Doppler signal) predict gout flares over 12 months.MethodsGout patients on urate-lowering therapy for at least the preceding 6 months were enrolled consecutively in this 12-month prospective, observational, single-centre study. A nested case–control analysis was performed. Cases were participants with at least one flare in the follow-up period, while controls did not self-report any gout flare. The US assessment included elbows, wrists, second MCP joints, knees, ankles, and first MTP joints. The US findings indicating MSU deposits [i.e. aggregates, double contour (DC) sign and tophi] were identified as present/absent according to the Outcome Measure in Rheumatology definitions. Power Doppler signal was scored semiquantitatively. Summated scores were calculated for each US finding.ResultsEighty-one gout participants were enrolled, and 71 completed the study. Thirty (42.3%) of 71 participants experienced at least one flare over 12 months, with a median of 2.0 flares. Cases had a greater US burden of MSU deposits (6.7 ± 4.7 vs 2.9 ± 2.6, P = 0.01) and power Doppler signal (3.73 ± 3.53 vs 0.82 ± 1.44, P &lt; 0.01) than controls, at baseline. The baseline US scores indicating MSU deposits and US-detected inflammation were significantly associated with the occurrence (total MSU score, adjusted odds ratio:1.75, 95% CI: 1.26, 2.43; power Doppler score, adjusted odds ratio: 1.63, 95% CI: 1.12, 2.40) and the number (total MSU score, adjusted incidence risk ratio: 1.17, 95% CI: 1.08, 1.26; power Doppler score, adjusted incidence risk ratio: 1.29, 95% CI: 1.19, 1.40) of flares over 12 months in multivariate analyses.ConclusionsBaseline US findings indicating MSU deposits and US-detected inflammation are independent predictors of gout flares over 12 months.
Different COVID-19 outcomes among systemic rheumatic diseases: a nation-wide cohort study
Authors: Bournia Vasiliki-Kalliopi , Fragoulis George E , Mitrou Panagiota , Mathioudakis Konstantinos , Tsolakidis Anastasios , Konstantonis George , Tseti Ioulia , Vourli Georgia , Tektonidou Maria G , Paraskevis Dimitrios , Sfikakis Petros P 
Published: August 2022

AbstractObjectivesTo investigate coronavirus disease 2019 (COVID-19)-associated risk of hospitalization and death in RA, AS, PsA, SLE and SSc in comparison with the general population during the first year of the pandemic, and compare their overall mortality with 2019.MethodsInterlinking nationwide electronic registries, we recorded confirmed COVID-19-associated infections, hospitalizations and deaths, and all-cause deaths between 1 March 2020 and 28 February 2021 in all adults with RA, AS, PsA, SLE and SSc under treatment (n = 74 970, median age 67.5, 51.2, 58.1, 56.2 and 62.2 years, respectively) and in random comparators from the general population matched (1:5) on age, sex and region of domicile. Deaths from all causes during 2019 were also recorded.ResultsCompared with the general population, incidence rates (IR) for COVID-19-associated hospitalization were higher in RA [IR ratio (IRR) 1.71(1.50–1.95)], SLE [2.0 (1.4–2.7)] and SSc [2.28 (1.29–3.90)], while COVID-19-associated death rates were higher in RA [1.91 (1.46–2.49)]. When focusing only on severe acute respiratory syndrome coronavirus 2–infected subjects, after adjusting for age and gender, the odds ratio for COVID-19 associated death was higher in RA [1.47 (1.11–1.94)] and SSc [2.92 (1.07–7.99)] compared with the general population. The all-cause mortality rate compared with the general population increased in RA during the first year of the pandemic (IRR 0.71) with reference to 2019 (0.59), and decreased in SSc (IRR 1.94 vs 4.36).ConclusionCOVID-19 may have a more severe impact in patients with systemic rheumatic disease than in the general population. COVID-19-related mortality is increased in subgroups of patients with specific rheumatic diseases, underscoring the need for priority vaccination and access to targeted treatments.
Coping strategies, emotional distress and perceived disease severity in a cohort of patients with rheumatoid arthritis: a mediation analysis
Authors: Tosato Sarah , Bonetto Chiara , Zanini Alice , Montanari Ilaria , Piccinelli Anna , Bixio Riccardo , Rossini Maurizio , Pacenza Giulio , Cristofalo Doriana , Fracassi Elena , Carletto Antonio 
Published: August 2022

AbstractObjectivesFew data are available on the role of emotional distress as a possible mediator of the relationship between coping strategies and the Patient Global Assessment (PGA). This study aims to investigate, in a large cohort of patients affected by RA, the relationship between specific copying strategies and PGA, and the role of emotional distress as a mediator.MethodsA total of 490 patients with RA completed a set of standardized assessments including the self-reported PGA, the Coping Orientation to the Problems Experienced (COPE-NVI) and the Hospital Anxiety and Depression Scale (HADS). A mediation analysis was conducted to investigate the role of emotional distress.ResultsThe effect of coping strategies on the PGA score was significantly mediated by the emotional distress for religious (total effect mediated 42.0%), planning (total effect mediated 17.5%), behavioural disengagement (total effect mediated 10.5%), and focus on and venting of emotions (total effect mediated 9.8%). Seven coping strategies (acceptance, positive reinterpretation and growth, active coping, denial, humour, substance use-mental disengagement) resulted directly associated to PGA total score, but no mediation effect was found. The remaining four coping strategies were not associated to the PGA score.ConclusionThis study suggests that coping strategies could be an important factor in the perceived disease severity. Consequently, in order to reduce PGA in patients with RA, a useful tool could be represented by the implementation of psychological interventions aiming to modify the specific coping styles. Moreover, to prevent or treat emotional distress seems to further reduce PGA.
Clinical trial transparency regulations: Implications to various scholarly publishing stakeholders
Authors: Abdul Razack Habeeb Ibrahim , Aranjani Jesil Mathew , Mathew Sam T 
Published: August 2022

AbstractAs thousands of 2019 Corona virus disease (Covid-19) clinical trials are continuously getting added to various registries these days, good practices on data sharing and transparency have become one of the prime topics of discussion than ever before. Although trial registration is considered a crucial step, there is a lack of integration between registration and published literature. Trial outcomes are a matter of public interest, but sponsor compliances are not adequate with the recommended guidelines. Although the global recognition of data transparency increases day by day, there is still a long journey to travel. It is high time that scholarly publishing stakeholders should put in a collaborative effort to check author compliance. In this article, we aimed to comprehend and discuss the imperative roles of various scholarly publishing stakeholders in improving clinical trial transparency during this pandemic situation and highlight the changing paradigm towards the pressing need for reporting clinical trial data more effectively.
Integrating Gender-Based Analysis Plus into Policy Responses to COVID-19: Lived Experiences of Lockdown in British Columbia, Canada
Authors: Smith Julia , Mũrage Alice , Lui Ingrid , Morgan Rosemary 
Published: August 2022

AbstractRecognition of the differential effects of COVID-19 on women has led to calls for greater application of gender-based analysis within policy responses. Beyond pointing out where such policies are implemented, there is little analysis of the effects of efforts to integrate gender-based analysis into the COVID-19 response. Drawing on interviews informing a lived experienced approach to policy analysis, this article asks if, how, and to what effect gender-based analysis was implemented within social and economic policy responses during the initial lockdown, in British Columbia, Canada. It finds that, despite a rhetorical commitment to gender-based analysis, policies failed to address everyday inequalities.
Transplanting larch trees into warmer areas increases the photosynthesis and its temperature sensitivity
Authors: Ju Yali , Wang Chuankuan , Wang Nan , Quan Xiankui 
Published: August 2022

Abstract
To investigate the effects of climate warming on photosynthesis, Dahurian larch (Larix gmelinii Rupr.) trees from four sites (spanning ~ 5.5° in latitude and ~4 °C of warming) within the geographic range in China were transplanted into a common garden close to the warmer border in 2004. Throughout the growing season of 2018, the CO2- and temperature-response curves of the photosynthesis in the common garden and at the original sites were measured. It was discovered that warming treatment considerably increased the maximum net photosynthetic rate (Amax) by 23.4–35.3% depending on the sites, signifying that warming upregulated Amax with respect to the degree of warming. At 25 °C, warming enhanced the maximum Rubisco carboxylation rate (Vcmax), maximum electron transport rate (Jmax), and mass-based leaf nitrogen concentration (Nmass). The climate warming effect (CWE) on Amax was positively associated with the CWEs on Vcmax, Jmax and Nmass, which indicated that warming promoted Amax primarily via increasing carboxylation and photosynthetic electron transport rates and leaf nitrogen supply. The CWE in optimal photosynthetic temperature (Topt) was significant for the trees from the northern sites rather than the southern sites; however, the effect vanished for the trees transplanted to the common garden; this implied that Topt exhibited limited local thermal acclimation. Nevertheless, warming narrowed the temperature-response curve, the effect of which was positively associated with the warming magnitude. These findings implied that trees transplanted into warmer areas changed the photosynthetic optimum temperature and sensitivity. In summary, our results deepen the understanding of the underlying mechanisms of intraspecific responses of photosynthesis to temperature changes, including which of the modeling would improve the prediction of tree growth and forest carbon cycling under climate warming.
The Assessment of Social Determinants of Health in Postsepsis Mortality and Readmission: A Scoping Review
Authors: Hilton Ryan S. , Hauschildt Katrina , Shah Milan , Kowalkowski Marc , Taylor Stephanie 
Published: July 2022

OBJECTIVE:
To summarize knowledge and identify gaps in evidence about the relationship between social determinants of health (SDH) and postsepsis outcomes.

DATA SOURCES:
We conducted a comprehensive search of PubMed/Medical Literature Analysis and Retrieval System Online, Excerpta Medica database, and the Cochrane Library.

STUDY SELECTION:
We identified articles that evaluated SDH as risk factors for mortality or readmission after sepsis hospitalization. Two authors independently screened and selected articles for inclusion.

DATA EXTRACTION:
We dual-extracted study characteristics with specific focus on measurement, reporting, and interpretation of SDH variables.

DATA SYNTHESIS:
Of 2,077 articles screened, 103 articles assessed risk factors for postsepsis mortality or readmission. Of these, 28 (27%) included at least one SDH variable. Inclusion of SDH in studies assessing postsepsis adverse outcomes increased over time. The most common SDH evaluated was race/ethnicity (n = 21, 75%), followed by payer type (n = 10, 36%), and income/wealth (n = 9, 32%). Of the studies including race/ethnicity, nine (32%) evaluated no other SDH. Only one study including race/ethnicity discussed the use of this variable as a surrogate for social disadvantage, and none specifically discussed structural racism. None of the studies specifically addressed methods to validate the accuracy of SDH or handling of missing data. Eight (29%) studies included a general statement that missing data were infrequent. Several studies reported independent associations between SDH and outcomes after sepsis discharge; however, these findings were mixed across studies.

CONCLUSIONS:
Our review suggests that SDH data are underutilized and of uncertain quality in studies evaluating postsepsis adverse events. Transparent and explicit ontogenesis and data models for SDH data are urgently needed to support research and clinical applications with specific attention to advancing our understanding of the role racism and racial health inequities in postsepsis outcomes.
Development and Preliminary Psychometric Testing of the Drake Atrial Electrogram Assessment Survey: DAEGAS
Authors: Drake Jeanette , Hanneman Sandra K. , McEwen Melanie M. , Ramirez Elda G. , Conti Vincent R. 
Published: July 2022

Background
Critical care nurses who care for postoperative cardiac surgery patients need such specialty knowledge as atrial electrograms (AEGs). An inadequate audit trail exists for psychometric performance of instruments to measure knowledge of AEGs.

Objectives
The aim of this study was to revise a previously tested instrument and assess evidence for content validity (content validity index), internal consistency (Cronbach α), and stability (correlation coefficient, r) reliability against the a priori criterion of 0.80.

Methods
The multiple-choice response, self-administered, paper-and-pencil instrument was revised to 20 items and named the Drake Atrial Electrogram Assessment Survey (DAEGAS). A panel of 6 AEG experts reviewed the DAEGAS for content validity evidence. The instrument was further revised to 19 items (13 knowledge and 6 AEG interpretation) and tested with 76 critical care nurses from the greater Houston metropolitan area.

Results
The content validity index was 0.93. Cronbach α was .51, and test-retest r was 0.74. Cronbach α increased to .60 and r was 0.73 with removal of 3 items: 2 items with a negative item-total correlation and 1 item that was transitioned to a sample question.

Discussion
Content validity evidence exceeded the a priori criterion. Internal consistency and stability reliability estimates did not meet the criterion, albeit the latter met the criterion recommended by psychometricians for a new instrument. Recommendations include further development of the DAEGAS to improve internal consistency estimates and testing for evidence of other forms of validity. Reliable and valid assessment of critical care nurse knowledge of AEGs will require improved psychometric performance of the DAEGAS.
Depth of Upper Lid Crease Construction in Asian Blepharoplasty
Authors: Chen William P. D. 
Published: July 2022

Summary:
The elegance of retrospective analysis of crease construction based on the levels of attachment is that it may be used to correlate a crease’s construction method with an outcome of crease depth based on medical record review. It expands on the current knowledge beyond simply describing a crease as being superficial or deep, and is useful for objective analysis of a technique’s merit.
Complex Nasal Reconstruction in a Wide-awake Ambulatory Setting: A Study of Efficacy and Perioperative Patient Experience
Authors: St. Denis-Katz Hannah N. , Bastianelli Michael , Macdonald Jillian , Zhang Jing 
Published: July 2022

Background:
The use of local anesthesia in nasal surgery has gained popularity as a cost-effective and safe alternative. With the potential benefit of reconstruction without using general anesthesia, the goal of the study was to evaluate the patient-reported experience in addition to surgical outcomes and perioperative complications.

Methods:
A mixed-methods study was completed with retrospective chart review and patient-reported outcome questionnaire. The primary outcome measures were demographics, oncologic and surgical details, and postoperative complications. Secondary outcome measures were aesthetic outcomes and procedure tolerance, which were gathered from the FACE-Q questionnaire.

Results:
Of the 22 patients who met inclusion criteria, nine patients (41%) had forehead flaps performed and 13 patients (59%) had multilayer reconstruction with local flaps and cartilage grafts. The average number of surgeries performed, including revisions, was 2.3 ± 0.2. The overall complication rate for reconstructions and revisions was 20%, most of these were minor complications. The overall subjective rating of patient’s appearance was excellent with an average score of 83.9 (± 17.3) out of 100. There was minimal appearance distress as a product of the surgery with an average score of 84.9 (±18.8). On a scale of one to five, patients reported an average of 4.3 for convenience, 3.8 for efficiency of setup and procedure, and 3.4 out of 5 for comfortability with having an operation performed on their face wide awake.

Conclusion:
Our study demonstrated that complex nasal reconstruction performed under local anesthetic in a minor procedure setting is a feasible and safe option with good patient-reported outcomes.
An update on rib grafting in rhinoplasty: which rib is right?
Authors: Drake Virginia E. , Mowery Alia J. , Nellis Jason C. 
Published: July 2022

Purpose of review
In revision or posttraumatic rhinoplasty, the quantity and quality of septal cartilage available for grafting is often deficient and auricular cartilage often provides insufficient strength for structural nasal reconstruction. Accordingly, rib cartilage serves as a reliable, abundant source of cartilage for grafting. However, the various sources of rib cartilage carry respective benefits and weaknesses. This review examines recent studies, novel applications and a comparison of the primary sources of rib cartilage, including autologous cartilage, irradiated cadaveric rib and fresh frozen cadaveric cartilage.

Recent findings
Options for rib cartilage include autologous, irradiated cadaveric rib, and more recently, reports on fresh frozen cadaveric cartilage. Studies continue to conclude that autologous and irradiated donor cartilage carry equivalent results, have similar rates of complication and have a comparable cost profile.

Summary
Regardless of the source, rib cartilage plays an important role in structural rhinoplasty, especially in revision cases. Although the risks, benefits and long-term results of autologous and radiated homologous cartilage have been evaluated in observational studies, fresh frozen rib cartilage will need further follow up before widespread use, although preliminary literature shows promise.
Patient-specific implants in orbital reconstruction
Authors: Hajibandeh Jeffrey , Lee Cameron 
Published: July 2022

Purpose of review
Advances in the use of patient-specific implants (PSIs) and virtual surgical planning (VSP) for reconstruction of primary and secondary traumatic orbital defects are explored.

Recent findings
PSIs and VSP are emerging technologies that promise to make complex orbital reconstructions safer and more predictable for patients. Recent studies highlight principles of implant design, the novel use of multiunit implant constructs, and utility of intraoperative imaging adjuncts to achieve favorable outcomes.

Summary
This article summarizes recent developments in PSIs for orbital reconstruction. A complete workflow including presurgical planning, execution in the operating room, postoperative analysis, and avoidance of common pitfalls and implant design errors are reviewed.
Enhanced Recovery after Surgery (ERAS) protocols in craniomaxillofacial surgery: an evidence-based review
Authors: Obayemi Adetokunbo , Tatum Sherard A. 
Published: July 2022

Purpose of review
Enhanced Recovery after Surgery (ERAS) refers to a patient centered, multidisciplinary team developed pathway aimed at reducing the surgical stress response and facilitating expedited patient postoperative recovery. These protocols have been largely developed in the general surgery literature and have led to vast improvements in the patient experience. With a growing shortage of hospital resources during the height of the COVID-19 pandemic there has been a growing push to apply these principles to a wide variety of specialties.

Recent findings
ERAS protocols are generally substantiated on three phases along the continuum of surgical care: preadmission optimization, intraoperative treatment, and postoperative management. In this article, the evidence for ERAS development in craniomaxillofacial surgery will be reviewed, and recommendations from prior studies for enhanced recovery will be outlined.

Summary
ERAS protocols have been proven effective in many surgical arenas, however, modification is needed for the craniomaxillofacial population. The implications for widespread implementation of ERAS protocols during these procedures are a potentially shortened length of stay, expedited early return to function, reduction in narcotic dependence, and reduction in postdischarge complications necessitating additional intervention.
The use of race-based terminology in the rhinoplasty literature
Authors: Newsome Hillary A. , Chi John J. 
Published: July 2022

Purpose of review
To provide an overview of the use of race-based terminology in the rhinoplasty literature.

Recent findings
The rhinoplasty literature is often indexed by race, with common usage of the terms Ethnic/Non-Caucasian/Nonwhite; African American/of African descent; Hispanic/Latinx; and Asian to refer to certain patient populations. There are wide variations in facial features within these populations, but specific traits may be more prevalent in patients with certain backgrounds. More recently, in particular within the ‘Asian rhinoplasty’ literature, titles have pivoted to include specific anatomic characteristics of interest, which offers a more objective way of discussing this topic.

Summary
The use of race and ethnicity to describe facial and nasal anatomy in the rhinoplasty literature introduces subjectivity and diminishes the validity of the rhinoplasty literature. We advocate the usage of specific physical and anatomic descriptions rather than race and ethnicity within the rhinoplasty literature.