bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epigenetics for Drug Discovery: Dissecting the Effect of High
Antipsychotic Dosage and D2 Blockage on Peripheral DNA
Methylation
Authors: Adanty Christopher , Kim Julia , Strauss John , Qian Jessica , Remington Gary , Borlido Carol , Graff Ariel , Gerretsen Philip , De Luca Vincenzo 
Published: April 2022

Abstract
Introduction The relationship between genetic polymorphisms of
antipsychotic drug-metabolizing agents and drug receptors has been often
investigated. DNA methylation is a form of epigenetic modification that
regulates gene expression. Few studies have analyzed the relationship between
genome-wide methylation patterns and antipsychotic dosage. The primary aim of
this pilot study was to investigate the association between antipsychotic dosage
and genome-wide DNA methylation in patients with schizophrenia (SCZ).
Methods Current dosage of antipsychotic medications was assessed in 136
patients with SCZ. Dosage was standardized using three different methods:
chlorpromazine equivalent dose (CPZe), defined daily dose (DDD), and percentage
of Lexicomp maximum dose (PM%). DNA methylation was measured in white
blood cells. Antipsychotic dosage was the primary outcome variable in a model,
including genome-wide methylation status as the main predictor.
Results This study did not show any association between DNA methylation
and dosage variation for CPZe, PM%, and DDD. However, the probe
cg271403389 was consistently associated with antipsychotic dosage across the
three standardization methods. When looking at the genomic location of the most
significant probes, we found that 15% were intergenic, 23% were
in the distal promoter, 9% in the 3′untranslated region,
32% in the gene body, 3% in the 5′ untranslated region,
15% in the proximal promoter, and 3% in the first exon.
Discussion This study shows the importance of investigating the
relationship between DNA methylation and optimal antipsychotic dosage to
personalize treatment in SCZ. Future studies require larger prescription
databases to build on the results of this analysis.
One-Year Audiologic Monitoring of Individuals Exposed to the 1995 Oklahoma City Bombing
Authors: Van Campen Luann E. , Dennis J. Michael , Hanlin Renee C. R. , King Sandra B. , Velderman Amy M. 
Published: April 2022

AbstractThis longitudinal study evaluated subjective, behavioral, and objective auditory function in 83 explosion survivors. Subjects were evaluated quarterly for 1 year with conventional pure-tone and extended high-frequencies audiometry, otoscopic inspections, immittance and speech audiometry, and questionnaires. There was no obvious relationship between subject location and symptoms or test results. Tinnitus, distorted hearing, loudness sensitivity, and otalgia were common symptoms. On average, 76 percent of subjects had predominantly sensorineural hearing loss at one or more frequencies. Twenty-four percent of subjects required amplification. Extended high frequencies showed evidence of acoustic trauma even when conventional frequencies fell within the normal range. Males had significantly poorer responses than females across frequencies. Auditory status of the group was significantly compromised and unchanged at the end of 1–year postblast.
Abbreviations: ANOVA= analysis of variance, CF = conventional frequencies (0.25–8 kHz), EHF = extended high frequencies (10–20 kHz), LSD = least significant difference, psi = air pressure measured in pounds per square inch, dB pSPL = decibel re: peak sound pressure level, Q = quarterly evaluations, TNT = trinitrotoluene
Acoustic-Phonetic Approach toward Understanding Neural Processes and Speech Perception
Authors: Koch Dawn Burton , McGee Therese J. , Bradlow Ann R. , Kraus Nina 
Published: April 2022

AbstractThis review paper describes an “acoustic-phonetic” experimental approach aimed at understanding normal and abnormal speech perception processes from both a behavioral and an electrophysiologic perspective. First, we consider the relevant acoustic characteristics of speech and identify a set of acoustic-phonetic classes that represent the parameters most important for making an acoustic signal sound like speech. Second, we review what is known about the neurophysiologic representation of acoustic-phonetic speech parameters in animal and human subjects. Third, we describe how an acoustic-phonetic approach has been useful in understanding the biologic basis of some auditory learning problems in children and in characterizing the behavioral and neurophysiologic changes resulting from speech-sound training. Finally, we discuss these findings and how they may expand the diagnostic and rehabilitative repertoire of practicing audiologists.
Abbreviations: F0 = fundamental frequency; F1, F2, etc. = first formant, second formant, etc; fMRI = functional magnetic resonance imaging; JND = just noticeable difference; MMN = mismatch negativity
Habilitation and Management of Auditory Processing Disorders: Overview of Selected Procedures
Authors: Musiek Frank 
Published: April 2022

AbstractThis article describes three management approaches that can be used with children with auditory processing difficulties and learning disabilities. These approaches were selected because they can be applied in a variety of settings by a variety of professionals, as well as interested parents. The vocabulary building procedure is one that potentially can increase the ability to learn new words but also can provide training on contextual derivation of information, which is key to auditory closure processes. This procedure also helps increase language base, which can also enhance closure abilities. Auditory memory enhancement is a simple technique that involves many complex brain processes. This procedure reduces detailed information to a more gestalt representation and also integrates the motor and spatial processes of the brain. This, in turn, more fully uses working memory and helps in formulization and recall of important concepts of the sensory input. Finally, several informal auditory training techniques are discussed that can be readily employed in the school or home setting. These auditory training techniques are those that are most relevant to the kinds of deficits most often observed in our clinic.
Abbreviations: ΑΜΕ = auditory memory enhancement, AT = auditory training, CAPD = central auditory processing disorder, CV = consonant-vowel, CVC = consonant-vowel-consonant
Theoretical and experimental assessment of genome-based prediction in landraces of allogamous crops
Authors: Hölker Armin C. , Mayer Manfred , Presterl Thomas , Bauer Eva , Ouzunova Milena , Melchinger Albrecht E. , Schön Chris-Carolin 
Published: April 2022

Significance
Genetic variation inherent in landraces is essential for broadening the genetic diversity of our crops. This study pioneers the development of a theoretical framework to link molecular inventories of plant genetic resources to phenotypic variation, allowing an informed choice of landraces and their crossing partners. We show that genome-based prediction of genetic values can be implemented successfully in landrace-derived material, despite a strongly reduced level of relatedness compared with elite germplasm. Theoretical derivations are validated with unique experimental data collected on two different landraces. Our results are a pivotal contribution toward the optimization of genome-enabled prebreeding schemes.
RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice
Authors: Zhong Xue , Choi Jin Huk , Hildebrand Sara , Ludwig Sara , Wang Jianhui , Nair-Gill Evan , Liao Tzu-Chieh , Moresco James J. , Liu Aijie , Quan Jiexia , Sun Qihua , Zhang Duanwu , Zhan Xiaoming , Choi Mihwa , Li Xiaohong , Wang Junmei , Gallagher Thomas , Moresco Eva Marie Y. , Beutler Bruce 
Published: April 2022

SignificanceMessenger RNA (mRNA) splicing is fundamental to protein expression in mammals. Homozygous deletion of single protein components of the splicing machinery or its regulatory factors is embryonic lethal. However, through forward genetic screening in mice, we identified a viable hypomorphic missense mutation of the splicing regulator RNPS1. Homozygous mutant mice displayed altered immune cell development due to excessive tumor necrosis factor (TNF)–dependent immune cell apoptosis. Splicing was impaired in CD8+T cells and hematopoietic stem cells from RNPS1 mutant mice. TNF knockout rescued hematopoiesis and dramatically reduced splicing defects in RNPS1 hematopoietic cells, demonstrating a surprising link between elevated TNF and defects in splicing caused by RNPS1 deficiency.
Corpus linguistics and clinical psychology
Authors: Collins Luke , Brezina Vaclav , Demjén Zsófia , Semino Elena , Woods Angela 
Published: April 2022

Abstract
Triangulating corpus linguistic approaches with other (linguistic and non-linguistic) approaches enhances “both the rigour of corpus linguistics and its incorporation into all kinds of research” (McEnery & Hardie, 2012: 227). Our study investigates an important area of mental health research: the experiences of those who hear voices that others cannot hear, and particularly the ways in which those voices are described as person-like. We apply corpus methods to augment the findings of a qualitative approach to 40 interviews with voice-hearers, whereby each interview was coded as involving ‘minimal’ or ‘complex’ personification of voices. Our analysis provides linguistic evidence in support of the qualitative coding of the interviews, but also goes beyond a binary approach by revealing different types and degrees of personification of voices, based on how they are referred to and described by voice-hearers. We relate these findings to concepts that inform therapeutic interventions in clinical psychology.
Audiology students’ opinions towards COVID-19 pandemic
Authors: Karakoc Kursad , Karabulut Mustafa , Kartal Ozcan Ecem , Mujdeci Banu 
Published: April 2022

Objective
This study aimed to evaluate the audiology students' opinions regarding their occupational perspective and their future expectations during the COVID-19 pandemic.

Methods
The study included 608 participants consisting of undergraduate and graduate students. Two question forms were used in the study. “Audiology students' opinions regarding their occupational perspective during the COVID-19 pandemic” containing 10 questions and “Audiology students' opinions regarding their future expectations” containing 8 questions were assessed.

Results
While the COVID-19 pandemic did not affect employment opportunities in the field of audiology, it significantly contributed to the increase of professional risks. Online education did not contribute to the learning process and professional competencies. More graduate students stated that the COVID-19 did not affect employment opportunities and increased professional risks but facilitated access to information compared to undergraduate students (p < .05). Undergraduate students stated that COVID-19 contributed more to the reconsideration of career plans and opinions about the profession compared to graduate students (p < .05). COVID-19 pandemic had a more negative effect on graduate students' future expectations compared to undergraduate students (p < .05).

Conclusion
To our view, the COVID-19 pandemic negatively influenced the occupational perspective of audiology students but did not affect their future expectations. While this process affected the career plan and perspective on the audiology profession of undergraduate students, it negatively impacted the professional risk perception and future expectations of graduate students.
ZnO/Ge core–shell nanowires and Ge nanotubes fabricated by chemical vapor deposition and wet etching
Authors: Sun Yong-Lie , Zheng Xiang-Dong , Jevasuwan Wipakorn , Fukata Naoki 
Published: April 2022

Abstract
One-dimensional germanium (Ge)-related nanostructures including core–shell nanowires and nanotubes with high specific surface area show enhanced performance in energy storage and electronic devices, and their structural control is important for further improving their performance and stability. In this work, we fabricated vertically formed ZnO/Ge core–shell nanowires with different shell thicknesses. The dependence of morphology, crystallinity, and internal stress of the nanowires on the shell growth time and temperature was investigated. By applying the wet-etching method to the ZnO/Ge core–shell heterojunction nanowires, we demonstrated the Ge nanotube fabrication and stress relaxation in Ge after ZnO core removal.
A fiber optic conjugate stress sensor for instantaneous tangent modulus detection targeting prognostic health monitoring applications
Authors: Kordell Jonathan , Yu Miao , Dasgupta Abhijit 
Published: April 2022

Abstract
In this work, a surface-mounted fiber optic conjugate stress sensor (FOCSS) is developed, fabricated, and experimentally demonstrated to accurately evaluate the instantaneous tangent modulus of various metals, thus allowing measurement of the elastic-plastic stress–strain behavior of the host material. The originally proposed embedded version of the conjugate stress (CS) sensor measured the deformations experienced in two fully embedded, ellipsoidal, collocated sensors of significantly different stiffnesses, and related those sensor deformations to host modulus via Eshelby’s equivalent inclusion method. In contrast, the current experimental study focuses on a surface-mounted implementation of the CS sensor. As Eshelby’s analysis is not applicable in this case, a simplified lumped-element spring model is developed to instantaneously relate the deformations in the CS sensor to the local stress–strain state of the host. Therefore, tangent modulus of the host can be estimated from the output of the FOCSS, which can serve as an important damage precursor in structural and prognostic health monitoring for a prominent set of failure mechanisms, including mechanical overstress, fatigue, and corrosion. In this study, the FOCSS data is used in conjunction with the lumped-element spring model to measure the elastic modulus of three different materials of significantly different stiffness: aluminum, copper, and steel. Additionally, as validation of instantaneous tangent modulus tracking, the elastic-plastic stress–strain curves of copper and steel are reconstructed from the FOCSS outputs during uniaxial tensile tests (with a goodness of fit R
2 > 0.98). The results demonstrate the ability of the FOCSS to detect instantaneous modulus as materials experience plastic deformation.
A novel AC loss measurement method for HTS coils based on parameter identification
Authors: Li Xin , Ren Li , Guo Shuqiang , Xu Ying , Shi Jing , Tang Yuejin , Li Jingdong 
Published: April 2022

Abstract
In the presence of AC current or AC magnetic field, superconductors will suffer AC loss. The measurement of AC loss is of great significance for applied superconductivity field. There are three main different methods for AC loss measurement. Among them, electrical measurement methods are widely researched by different laboratories. The existing electrical measurement method mainly has two shortcomings: it is difficult to be used in High temperature superconductivity (HTS) coils with high inductance and only available for periodic current conditions (only obtains average value of AC loss for one or several current periods and cannot obtain AC loss at any instant). In this paper, a novel AC loss measurement method based on parameter identification is proposed to solve the second shortcoming (only available for periodic current conditions). This novel method measures AC loss by identifying HTS coils’ resistance and inductance at any moment, which is completely different from previous measurement methods. The theoretical basis of this novel method mainly contains three parts: equivalent circuit of HTS coils, instantaneous power identification from Poynting theorem and parameter identification based on recursive least squares with fixed forgetting factor. Compared with AC loss measurement results of previous electrical method (integral method), the validity of this novel measurement method is demonstrated. In theory, this novel method can measure AC loss for any current waveform (periodic and aperiodic current), which greatly widens measurement range of previous electrical method. The principle of this novel method and detailed experimental results are discussed and analyzed in this paper.
Probing the delocalized core-hole via inner-shell excitation in N2
Authors: Xu Yuan-Chen , Wang Shu-Xing , Du Xiao-Jiao , Wang Li-Han , Zhu Lin-Fan 
Published: April 2022

Abstract
The dispute about whether the 1s core-hole is localized on one atom or delocalized over both in a homonuclear diatomic molecule has continued for decades, which has been extensively studied by the photoelectron and electron–ion coincidence spectroscopies. For N2, if the 1s core-hole is delocalized, the K-shell excitation into the 1π

g
orbital should split into two components, i.e., the dipole-allowed transition from the ungerade 1σ

u
state and the dipole-forbidden transition from the gerade 1σ

g
state. However, only the dipole-allowed transition has been observed up to now. Here, we report the inner-shell electron energy loss spectra of N2 at different scattering angles with an incident electron energy of 1500 eV and an energy resolution of 65 meV. The vibrational structures of both the dipole-allowed

(

1
s

σ

u

)

−
1

(

1

π

g

)

1

and dipole-forbidden

(

1
s

σ

g

)

−
1

(

1

π

g

)

1

states of N2 have been identified at different momentum transfers. The splitting between the

(

1

σ

g

)

−
1

(

1

π

g

)

1

and

(

1

σ

u

)

−
1

(

1

π

g

)

1

states with the reverse symmetry is determined to be 67 ± 7 meV. Moreover, the momentum transfer dependence behavior of the transition intensity ratio agrees with the theoretical predictions, as increasing to a maximum and then decreasing. The experimental observations clearly show that the inner most electrons can be described by 1σ

g
and 1σ

u
, which indicates that the inner-shell 1s core-hole of N2 is delocalized over two N atoms based on the excitation process.
Revealing superradiant emission in the single-to-bulk transition of quantum emitters in nanodiamond agglomerates
Authors: Gutsche Jonas , Zand Ashkan , Bültel Marek , Widera Artur 
Published: April 2022

Abstract
Individual quantum emitters form a fundamental building block for emerging quantum technologies. Collective effects of emitters, such as superradiance, might improve the performance of applications even further. When scaling materials to larger sizes, however, the optical density of states is modified by the surrounding material, and the collective coupling in small domains might be covered by transitions to bulk properties due to the presence of multiple collectively emitting domains, which inhomogeneously add. Here, we probe the optical properties of nitrogen vacancy centers in agglomerates of nanodiamonds. We quantify the transition from individual emitters to bulk emission by fluorescence lifetime measurements, and find a transition to occur on a length scale of

∼

3

wavelengths around the emitter. While our lifetime measurements are consistent with superradiant decay, the second-order correlation function, which is a standard measure to reveal collective properties, fails to probe collective effects for our case of an ensemble of collectively contributing domains to the emission. Therefore, we propose and apply a new measure to trace collective effects based on the intensity fluctuations of the emitted light. Our work points toward systematically studying collective effects in a scalable solid-state quantum system, and using them for quantum optical applications in agglomerates of highly-doped nanodiamonds.
Gauge field production and Schwinger reheating in runaway axion inflation
Authors: Hashiba Soichiro , Kamada Kohei , Nakatsuka Hiromasa 
Published: April 2022

Abstract
In a class of (pseudoscalar) inflation, inflationary phase is followed by a kination phase,
where the Universe is dominated by the kinetic energy of the inflaton that runs away in a vanishing scalar potential.
In this class of postinflationary evolution of the Universe, reheating of the Universe cannot be achieved by the inflaton
particle decay, which requires its coherent oscillation in a quadratic potential.
In this study, we explore the U(1) gauge field production through the Chern-Simons coupling between the pseudoscalar
inflaton and the gauge field during the kination era
and examine the subsequent pair-particle production induced by the amplified gauge field known as the Schwinger effect,
which can lead to reheating of the Universe.
We find that with a rough estimate of the Schwinger effect for the Standard Model hyper U(1) gauge field
and subsequent thermalization of the pair-produced particles,
a successful reheating of the Universe can be achieved
by their eventual domination over the kinetic energy of the inflaton,
with some reasonable parameter sets.
This can be understood as a concrete realization of the “Schwinger reheating”.
Constraints from the later-time cosmology are also discussed.
A Variable Step-size Normalized Least Mean Square Algorithm with Orthogonal Correction Factors
Authors: Li Ru , Zhai Shu-ying , Wang Pan , Zhi Yong-feng 
Published: April 2022

Abstract
To improve the performance of the adaptive filters, this paper presents a variable step-size normalized least mean square algorithm with orthogonal correction factors, which uses an exponential function to obtain proper smoothing factors from the projected error norm. Simulation results show that the proposed algorithm is superior in terms of convergence rate and estimation error compared with traditional NLMS-OCF algorithm.
Research on Optimizing Multimodal Transport Path under the Schedule Limitation Based on Genetic Algorithm
Authors: Jiang Cheng 
Published: April 2022

Abstract
Multimodal transportation is getting more and more attention due to its economical and efficient characteristics. Choosing a reasonable transportation plan can effectively control transportation costs. Considering that there are fixed schedules for railway and waterway transportation in real life, this article will establish a multimodal transportation route optimization model with the goal of minimizing the total transportation cost consisting of transportation cost, transit cost, waiting cost and carbon emission cost. The genetic algorithm based on preservation strategy and immigration strategy is used to solve the model. The effectiveness of the model is proved by the case study, and it can provide decision support for the choice of multimodal transportation scheme.
Particle swarm optimization algorithm with proportional factor based on Nash equilibrium
Authors: Luo Wenxin 
Published: April 2022

Abstract
Based on the global gradient-less stochastic search method of traditional particle swarm optimization algorithm, an improved particle swarm optimization algorithm for finding mixed-strategy Nash equilibrium is proposed in view of the shortcomings of prone particle overflow and unconstrained relationship between individual dimensions. In the improved evolution equation, the position function is improved to conform to the concept and properties of the combination of strategies, and the proportional factor is introduced to ensure that the numerical value of particle iteration is mapped to the solution space of normal form game. Through the test of several groups of classical examples, the results show that the algorithm not only improves efficiency and accuracy, but also solves the problems of divergence of particle and low efficiency of iteration. The experiments show that the algorithm has good practical performance.