bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diacerein counteracts acetaminophen-induced hepatotoxicity in mice via targeting NLRP3/caspase-1/IL-1β and IL-4/MCP-1 signaling pathways
Authors: Elshal Mahmoud , Abdelmageed Marwa E. 
Published: March 2022

AbstractThe current study aims at repurposing the anti-arthritic drug diacerein (DCN) for the treatment of acetaminophen hepatotoxicity and investigating the potential underlying mechanisms. Mice were randomly divided into six groups receiving either no treatment (control group), 20 mg/kg DCN i.p, 400 mg/kg acetaminophen i.p, DCN 4 h before acetaminophen, DCN 2 h after acetaminophen, or 400 mg/kg N-acetylcysteine (NAC) i.p, 2 h after acetaminophen. Biomarkers of liver dysfunction, oxidative stress, and apoptosis were assessed. Hepatic necroinflammatory changes were evaluated along with hepatic expression of NF-κB and caspase-1. The levels of NLRP3, IL-1β, IL-4, MCP-1, and TNF-α in the liver, as well as CYP2E1 mRNA expression, were measured. Diacerein significantly reduced biomarkers of liver dysfunction, oxidative stress, hepatocyte necrosis, and infiltration of neutrophils and macrophages whether administered 4 h before or 2 h after acetaminophen. Further, the effects were comparable to those of NAC. Diacerein also counteracted acetaminophen-induced hepatocellular apoptosis by increasing Bcl-2 and decreasing Bax and caspase-3 expression levels. Moreover, DCN normalized hepatic TNF-α and significantly decreased NF-κB p65 expression. Accordingly, DCN can prevent or reverse acetaminophen hepatotoxicity in mice, suggesting potential utility as a repurposed drug for clinical treatment.
Re-Os Geochronology of the Liuchapo Formation across the Ediacaran-Cambrian Boundary of the Yangtze Block (South China)
Authors: Fu Yong , Wang Fuliang , Guo Chuan , Li Chao , Xia Peng 
Published: March 2022

AbstractThe Ediacaran-Cambrian (E-C) succession in South China records remarkable oceanic, biological and geochemical variations, but it was not well defined geochronologically, which hinders the interpretation of the spatio-temporal seawater chemical architecture during the time E-C interval. This study presents two Re-Os isochron ages of 520.2 ± 6.1 and 561.7 ± 8.5 Ma for the barite-rich black shales from the top Liuchapo and Doushantuo formations respectively in Tianzhu County, Guizhou Province. In combination with existing age data, the two new Re-Os isochron ages suggest that the Liuchapo Formation was deposited between 550 and 520 Ma. Moreover, like the polymetallic Ni-Mo-PGE layers of shelf margin (or platform) facies and V-rich horizons of transitional (or shelf slope) to deep-water facies, the barite deposits were likely formed due to differential mineralization. The timing offset likely resulted from differential elemental concentration related to certain local factors (i.e., hydrothermal fluids, seawater redox and biological activity). The isochron-derived initial 187Os/188Os ratios of the top Liuchapo Formation (0.902 ± 0.048) and the Doushantuo Formation (0.740 ± 0.042) fall within the range of continental weathering flux (1.54) and oceanic crust (0.126), implying the involvement of marine hydrothermal fluids. Moreover, their difference of initial 187Os/188Os ratios may reflect variations of continental weathering intensity and uplift magnitude.
Overcoming Frege’s curse: heuristic reasoning as the basis for teaching philosophy of science to scientists
Authors: Grüne-Yanoff Till 
Published: March 2022

AbstractA lot of philosophy taught to science students consists of scientific methodology. But many philosophy of science textbooks have a fraught relationship with methodology, presenting it either a system of universal principles or entirely permeated by contingent factors not subject to normative assessment. In this paper, I argue for an alternative, heuristic perspective for teaching methodology: as fallible, purpose- and context-dependent, subject to cost-effectiveness considerations and systematically biased, but nevertheless subject to normative assessment. My pedagogical conclusion from this perspective is that philosophers should aim to teach science students heuristic reasoning: strategies of normative method choice appraisal that are sensitive to purposes, contexts, biases and cost-effectiveness considerations; and that we should do so by teaching them exemplars of such reasoning. I illustrate this proposal at the hand of three such exemplars, showing how they help students to appreciate the heuristic nature of both methods and methodology, and to normatively assess method choice in such circumstances.
Blue–green water utilization in rice–fish cultivation towards sustainable food production
Authors: Ahmed Nesar , Hornbuckle John , Turchini Giovanni M. 
Published: March 2022

AbstractIntegrated rice–fish culture is a competitive alternative to rice monoculture for environmental sustainability and food productivity. Compared to rice monoculture, rearing fish in rice field ecosystems could increase food (rice and fish) production from this coculture. Moreover, the water productivity of rice–fish coculture is considerably higher than that of rice monoculture, because of double cropping. Despite these benefits, rice–fish coculture has not yet been broadly practiced. One of the potential challenges for the wider adoption of rice–fish coculture is water management. There are two forms of water involved in rice–fish cultivation: (1) blue water–surface and groundwater, and (2) green water–soil water from rainfall. The aim of this article is to focus on key factors determining the adoption of rice–fish cultivation through the effective utilization of blue–green water. We suggest that the efficient application of blue and green water in rice–fish coculture could help confronting water scarcity, reducing water footprint, and increasing water productivity.
Electro-lubrication in Janus transition metal dichalcogenide bilayers
Authors: Li Hao , Guo Yufeng , Guo Wanlin 
Published: March 2022

AbstractLubrication induced by a vertical electric field or bias voltage is typically not applicable to two-dimensional (2D) van der Waals (vdW) crystals. By performing extensive first-principles calculations, we reveal that the interlayer friction and shear resistance of Janus transition metal dichalcogenide (TMD) MoXY (X/Y = S, Se, or Te, and X ≠ Y) bilayers under a constant normal force mode can be reduced by applying vertical electric fields. The maximum interlayer sliding energy barriers between AA and AB stacking of bilayers MoSTe, MoSeTe, and MoSSe decrease as the positive electric field increases because of the more significant counteracting effect from the electric field energy and the more significant enhancement in interlayer charge transfer in AA stacking. Meanwhile, the presence of negative electric fields decreases the interlayer friction of bilayer MoSTe, because the electronegativity difference between Te and S atoms reduces the interfacial atom charge differences between AA and AB stacking. These results reveal an electro-lubrication mechanism for the heterogeneous interfaces of 2D Janus TMDs.
Application of additively manufactured 3D scaffolds for bone cancer treatment: a review
Authors: Hou Yanhao , Wang Weiguang , Bartolo Paulo 
Published: March 2022

AbstractBone cancer is a critical health problem on a global scale, and the associated huge clinical and economic burdens are still rising. Although many clinical approaches are currently used for bone cancer treatment, these methods usually affect the normal body functions and thus present significant limitations. Meanwhile, advanced materials and additive manufacturing have opened up promising avenues for the development of new strategies targeting both bone cancer treatment and post-treatment bone regeneration. This paper presents a comprehensive review of bone cancer and its current treatment methods, particularly focusing on a number of advanced strategies such as scaffolds based on advanced functional materials, drug-loaded scaffolds, and scaffolds for photothermal/magnetothermal therapy. Finally, the main research challenges and future perspectives are elaborated.
FPGA implantations of TRNG architecture using ADPLL based on FIR filter as a loop filter
Authors: Meitei Huirem Bharat , Kumar Manoj 
Published: March 2022

AbstractThis article describes about the design, implementation, and analysis of a true random number generator (TRNG) employing an all-digital phase-locked loop (ADPLL) based on a finite impulse response (FIR) filter as the digital loop filter and implemented on the Artix 7(XC7A35T-CPG236-1) field programmable gate array (FPGA) board using the Xilinx Vivado v.2015.2 design suite. The coefficients of a 3rd-order broadcast low-pass digital FIR filter are computed using the Keiser window method. The MATLAB-FDA tool is used to calculate the filter coefficient. After reducing the bias in the sequence using the XOR-corrector post-processing approach, the suggested ADPLL-based TRNG designs created an unbiased stochastic random number with an overall throughput of 200 Mbps for both designs. The first proposed FIR-ADPLL-based TRNG design (FAT-1) consumes 0.072 W of power, whereas the second proposed FIR-ADPLL-based TRNG design (FAT-2) consumes 0.074 W. The resulting bitstream is verified for randomness using national institute of standards and technology (NIST) test following post-processing. Digital storage oscilloscope (DSO) is interfaced to the Artrix-7 FPGA board in order to capture the TRNG output waveforms. Both the proposed FIR-based ADPLL-TRNG designs passed the NIST SP 800-22 test, indicating that they are well-suited for a variety of industrial applications, including network security, cybersecurity, banking security, smart cards, radio-frequency identification tags, Internet of Things, and Industrial Internet of Things.
Cumulative Risk and Internalizing and Externalizing Problems in Early Childhood: Compensatory and Buffering Roles of Family Functioning and Family Regularity
Authors: Hogye Sara I. , Lucassen Nicole , Jansen Pauline W. , Schuurmans Isabel K. , Keizer Renske 
Published: March 2022

AbstractIn this preregistered study, we studied the extent to which family functioning and family regularity compensated for (compensatory model of resilience, Garmezy et al., Child Development 55:97–111, 1984) and buffered against (risk-protective factor model of resilience, Fergus and Zimmerman, Annual Review of Public Health 26:399–419, 2005) the influence of cumulative risks (CRs) on young children’s internalizing and externalizing problems. We conducted path analyses on multi-informant, longitudinal data from 3159 families enrolled in the Generation R Study, a large prospective birth cohort in the Netherlands. Children self-reported on internalizing and externalizing problems at age six. Mothers and fathers reported on 48 CRs between birth and child age five. Mothers reported on family regularity items at child ages two and four, and on family functioning at child age four. CR was positively associated with girls’ and boys’ internalizing problems, and with boys’ externalizing problems. We did not find support for a compensatory or buffering role of family functioning on the association between CR and children’s internalizing or externalizing problems. Our findings suggest that the use of a CR index may be beneficial for identifying children who are at higher risk for developing internalizing and externalizing problems in the early school years, as well as for planning treatment and intervention.Keywords: Cumulative risk, Internalizing problems, Externalizing problems, Family functioning, Family regularity, Early childhood.
Combining experimental and theoretical insights for reduction of CO2 to multi-carbon compounds
Authors: Brewis Ian , Shahzad Rana-Faisal , Field Robert W. , Jedidi Abdesslem , Rasul Shahid 
Published: March 2022

AbstractThe electrochemical reduction of carbon dioxide is a promising method for both recycling of atmospheric CO2 and storing renewably produced electrical energy in stable chemical bonds. In this paper, we review the current challenges within this promising area of research. Here we provide an overview of key findings from the perspective of improving the selectivity of reduction products, to serve as a contextual foundation from which a firmer understanding of the field can be built. Additionally, we discuss recent innovations in the development of catalytic materials selective toward C3 and liquid products. Through this, we form a basis from which key mechanisms into C3 products may be further examined. Carbon–carbon (C–C) bond formation provides a key step in the reduction of CO2 to energy dense and high value fuels. Here we demonstrate how variations in catalytic surface morphology and reaction kinetics influence the formation of multi-carbon products through their impact on the formation of C–C bonds. Finally, we discuss recent developments in the techniques used to characterise and model novel electrocatalysts. Through these insights, we hope to provide the reader with a perspective of both the rapid progress of the field of electrocatalysis, as well as offering a concise overview of the challenges faced by researchers within this rapidly developing field of research.
Micromechanical and Ultrastructural Properties of Abdominal Aortic Aneurysms
Authors: Hossack Martin , Fisher Robert , Torella Francesco , Madine Jillian , Field Mark , Akhtar Riaz 
Published: March 2022

AbstractAbdominal aortic aneurysms are a common condition of uncertain pathogenesis that can rupture if left untreated. Current recommended thresholds for planned repair are empirical and based entirely on diameter. It has been observed that some aneurysms rupture before reaching the threshold for repair whilst other larger aneurysms do not rupture. It is likely that geometry is not the only factor influencing rupture risk. Biomechanical indices aiming to improve and personalise rupture risk prediction require, amongst other things, knowledge of the material properties of the tissue and realistic constitutive models. These depend on the composition and organisation of the vessel wall which has been shown to undergo drastic changes with aneurysmal degeneration, with loss of elastin, smooth muscle cells, and an accumulation of isotropically arranged collagen. Most aneurysms are lined with intraluminal thrombus, which has an uncertain effect on the underlying vessel wall, with some authors demonstrating a reduction in wall stress and others a reduction in wall strength. The majority of studies investigating biomechanical properties of ex vivo abdominal aortic aneurysm tissues have used low-resolution techniques, such as tensile testing, able to measure the global material properties at the macroscale. High-resolution engineering techniques such as nanoindentation and atomic force microscopy have been modified for use in soft biological tissues and applied to vascular tissues with promising results. These techniques have the potential to advance the understanding and improve the management of abdominal aortic aneurysmal disease.
On locally analytic vectors of the completed cohomology of modular curves
Authors: Pan Lue 
Published: March 2022

AbstractWe study the locally analytic vectors in the completed cohomology of modular curves and determine the eigenvectors of a rational Borel subalgebra of$\mathfrak {gl}_2(\mathbb {Q}_p)$. As applications, we prove a classicality result for overconvergent eigenforms of weight 1 and give a new proof of the Fontaine–Mazur conjecture in the irregular case under some mild hypotheses. For an overconvergent eigenform of weightk, we show its corresponding Galois representation has Hodge–Tate–Sen weights$0,k-1$and prove a converse result.
Harmony between Man and His Environment: Reviewing the Trump Administration’s Changes to the National Environmental Policy Act in the Context of Environmental Racism
Authors: Kolencik Gabrielle M. 
Published: March 2022

AbstractThis article aims to show how the changes to NEPA by the Trump Administration are an act of environmental racism, defined as “[i]ntentional or unintentional racial discrimination in environmental policy‐making, enforcement of regulations and laws, and targeting of communities for the disposal of toxic waste and siting of polluting industries.”
ON THE DIVISOR FUNCTION OVER NONHOMOGENEOUS BEATTY SEQUENCES
Authors: ZHANG WEI 
Published: March 2022

AbstractWe consider sums involving the divisor function over nonhomogeneous (
$\beta \neq 0$
) Beatty sequences
$ \mathcal {B}_{\alpha ,\beta }:=\{[\alpha n+\beta ]\}_{n=1}^{\infty } $
and show that
$$ \begin{align*} \sum_{n\leq N,\ n\in\mathcal{B}_{\alpha,\beta}}d(n) =\alpha^{-1}\sum_{m\leq N}d(m) +O(N^{1-1/(\tau+1)+\varepsilon}), \end{align*} $$
where N is a sufficiently large integer,
$\alpha $
is of finite type
$\tau $
and
$\beta \neq 0$
. Previously, such estimates were only obtained for homogeneous Beatty sequences or for almost all
$\alpha $
.
The First Catholic Diocese in Asia and the Spread of Catholicism: Juan de Albuquerque, Bishop of Goa, 1538–1553
Authors: Paiva José Pedro 
Published: March 2022

AbstractThis article offers an interpretation of the actions of the Franciscan Juan de Albuquerque as bishop of the first Catholic diocese in Asia. The analysis considers the local impacts of the episcopal government and the connectivities of its action, particularly through comparison with similar processes adopted in Spanish America. Based on a wide range of historical sources and cross-referencing them, it investigates how Albuquerque governed in three stages: first, describing the enormous challenges he faced; second, outlining his profile; and third, proposing a reconstruction of his government and the implications it had on the dissemination of Catholicism. The hypothesis raised at the outset is that, in Asia, the Bishop of Goa built a structure that was inspired by the matrix and dynamics of the Portuguese dioceses, which were then adapted to the specificities of the local situation. Accordingly, it is necessary to review the thesis of Charles Boxer, for whom the dynamics of evangelization in the spaces overseen by the Iberian empires from the 16th century onwards were generated essentially by the missionaries from the regular clergy and by the monarchies. By shifting the focus to the actions of a single bishop, the article demonstrates that Albuquerque, the diocesan church he created from scratch, and the secular clergy should not be underestimated.
Entomopathogenic nematodes associated with organic honeybush (Cyclopia spp.) cultivation in South Africa
Authors: Daramola Fisayo Y. , Lewu Francis B. , Malan Antoinette P. 
Published: March 2022

Abstract
Entomopathogenic nematodes (EPNs) of the genera Steinernema and Heterorhabditis have demonstrated great potential as useful bio-control agents in the management of certain important soil-inhabiting insect pests of agricultural crops. In a survey of nematodes associated with organic honeybush cultivation, soil samples were obtained from nine organic honeybush plots, which are located in the Bredasdorp area of the Western Cape province of South Africa. The EPNs were isolated from soil by baiting with larvae of Galleria mellonella (greater wax moth) and identified by the amplification of the internal transcribed spacer region using the primer set TW81 and AB28. EPNs were abundant in the honeybush orchards, accounting for about 50% of the sampled fields and five EPN species were identified including Heterorhabditis bacteriophora, Heterorhabditis safricana, Steinernema khoisanae,. Steinernema nguyeni, Oscheius sp. and an unknown EPN, therefore suggesting a substantial diversity of EPNs in the sampled fields. A 100% mortality of infected G. mellonella larvae was recorded within 48 h of exposure to the nematodes. However, although these EPNs have been previously reported in South Africa, it is the first time they are found in such diversity on a conservative tillage management system in organic honeybush cultivation.
Κολληθέντɛς in Acts 17.34 and the Establishment of the Athenian Church
Authors: Evans David A. 
Published: March 2022

AbstractIt is commonly stated that while the author of Acts records some conversions that resulted from Paul's Athenian ministry, it is unlikely that a church was established in the city. This article argues, through an analysis of the use of the κολλάω word family in Luke-Acts, the Septuagint, early Christian writings and other relevant texts, that Luke uses the participle κολληθέντɛς as a way of signifying that a Christian community was indeed gathered together in Athens at this time. Leaving other social groups to join Paul and the other new believers, the new group is fused together by their shared faith, forming a new faith community in this ancient city.
Geometrically constrained path planning for robotic grasping with Differential Evolution and Fast Marching Square
Authors: Muñoz Javier , López Blanca , Quevedo Fernando , Barber Ramón , Garrido Santiago , Moreno Luis 
Published: March 2022

AbstractThis paper presents a new approach for geometrically constrained path planning applied to the field of robotic grasping. The method proposed in this paper is based on the Fast Marching Square (FM
$\, ^2$
) and a path calculation approach based on an optimization evolutionary filter named Differential Evolution (DE). The geometric restrictions caused by the link lengths of the kinematic chain composed by the robot arm and hand are introduced in the path calculation phase. This phase uses both the funnel potential of the surroundings created with FM
$\, ^2$
and the kinematic constraints of the robot as cost functions to be minimized by the evolutionary filter. The use of an optimization filter allows for a near-optimal solution that satisfies the kinematic restrictions, while preserving the characteristics of a path computed with FM
$\, ^2$
. The proposed method is tested in a simulation using a robot composed by a mobile base with two arms.
Integrating burrowing crayfish and waterfowl conservation management on moist-soil wetlands
Authors: Bloomer Caitlin C , Taylor Christopher A , Distefano Robert J 
Published: March 2022

SummaryThe North American Waterfowl Management Plan highlights the importance of enhancing waterfowl habitat for productivity and resilience. Many forms of land management are conducted in wetlands to support the diverse communities of waterfowl and other species. Primary burrowing crayfish are also abundant and important in these environments, but little research is available assessing the effects of waterfowl land management on primary burrowers. We examined the response of the digger crayfish,Creaserinus fodiens, to the common vegetation management practices of mowing and disking at waterfowl conservation areas in south-eastern Missouri. Our results demonstrated that at a fine scale, crayfish density was affected by only canopy cover. We also highlighted distributional effects of landscape-level environmental variables and suggested that habitat generalists were tolerant of vegetation management, responding more to vegetation composition and broader landscape effects. We discuss wetlands conservation practices and suggest that burrowing crayfish management would integrate well with some current management strategies for waterfowl.