bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of the cognitive functional therapy (CFT) in patients with chronic nonspecific low back pain: a study protocol for a randomized sham-controlled trial
Authors: de Lira Mariana Romano , de Mello Meziat-Filho Ney Armando , Silva Gabriela Zuelli Martins , Chaves Thaís Cristina 
Published: July 2022

Abstract
Background
Chronic low back pain is a public health problem, and there is strong evidence that it is associated with a complex interaction of biopsychosocial factors. Cognitive functional therapy (CFT) is a promising new intervention that deals with potentially modifiable multidimensional aspects of pain (e.g., provocative cognitive, movement, and lifestyle behaviors).

Methods
To investigate the efficacy of CFT compared with a sham intervention for pain intensity and disability post-intervention (immediately after the last session) in patients with non-specific chronic low back pain (CLBP). This study is a randomized controlled trial in which 152 (18–60 years old) patients with CLBP will be enrolled. The patients will be randomly allocated to receive (1) CFT intervention or (2) sham intervention. The experimental group will receive individualized CFT in a pragmatic manner (5 to 7 sessions) based on the clinical progression of the participants. The sham group will attend six sessions: consisting of 30 min of photobiomodulation using a detuned device and more than 15 min of talking about neutral topics. Patients from both groups also will receive an educational booklet (for ethical reasons). Participants will be assessed pre and post-intervention, 3 months, and 6 months after randomization. The primary outcomes will be pain intensity and disability post-intervention. The secondary outcomes will be: pain intensity and disability at 3- and 6-month follow-up, as well as self-efficacy, global perceived effect of improvement, and functioning post-intervention, 3-, and 6-month follow-up. The patients and the assessor will be blinded to the treatment administered (active vs. sham).

Statistical analysis
The between-group differences (effects of treatment), as well as the treatment effect for the primary and secondary outcomes, and their respective 95% confidence intervals will be calculated by constructing linear mixed models.

Discussion
To the best of our knowledge, the current study will be the first to compare CFT vs. sham intervention. Sham-controlled RCTs may help to understand the influence of non-specific factors on treatment outcomes. Considering complex interventions as CFT, it is imperative to understand the impact of contextual factors on outcomes.

Trial registration
ClinicalTrials.gov NCT04518891. First Posted: August 19, 2020.
Regional seropositivity for Borrelia burgdorferi and associated risk factors: findings from the Rhineland Study, Germany
Authors: Coors Annabell , Hassenstein Max J. , Krause Gérard , Kerrinnes Tobias , Harries Manuela , Breteler Monique M. B. , Castell Stefanie 
Published: July 2022

AbstractBackgroundLyme borreliosis is the most prevalent vector-borne disease in Europe, and numbers might increase due to climate change. However, borreliosis is not notifiable in North Rhine-Westphalia (NRW), Germany. Hence, little is known about the current human seroprevalence in NRW. However, the proportion ofBorrelia burgdorferisensu lato-infected ticks has increased in a NRW nature reserve. The literature suggests increasing age and male sex as risk factors for seropositivity, whereas the influence of socioeconomic status is controversial. Thus, we aimed to determine regional seropositivity forBorrelia burgdorferisensu lato (B. burgdorferis.l.) and its risk factors in the Rhineland Study population in Bonn, NRW, and to compare it with previous surveys to evaluate potential effects of climate change.MethodsWe assessed seropositivity in 2865 Rhineland Study participants by determining immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies forB. burgdorferis.l. using a two-step algorithm combining enzyme-linked immunosorbent assay tests and line immunoblots. We calculated the odds of being classified as IgG or IgM positive as a function of age, sex, and educational level using binomial logistic regression models. We applied varying seropositivity classifications and weights considering age, sex and education to compensate for differences between the sample and regional population characteristics.ResultsIgG antibodies forB. burgdorferis.l. were present in 2.4% and IgM antibodies in 0.6% of the participants (weighted: 2.2% [IgG], 0.6% [IgM]). The likelihood of IgG seropositivity increased by 3.0% (95% confidence interval [CI] 1.5–5.2%) per 1 year increase in age. Men had 1.65 times the odds for IgG seropositivity as women (95% CI 1.01–2.73), and highly educated participants had 1.83 times the odds (95% CI 1.10–3.14) as participants with an intermediate level of education. We found no statistically significant link between age, sex, or education and IgM seropositivity. Our weighted and age-standardized IgG seroprevalence was comparable to the preceding serosurvey German Health Interview and Examination Survey for Adults (DEGS) for NRW.ConclusionsWe confirmed that increasing age and male sex are associated with increased odds for IgG seropositivity and provide evidence for increased seropositivity in the highly educated group.B. burgdorferis.l. seropositivity remained constant over the past decade in this regional German population.Graphical abstract
Isobavachalcone attenuates TNF-α-induced ICAM-1 and VCAM-1 expression in human umbilical vein endothelial cells by regulating the NF-κB signaling pathway
Authors: Lee Ae Sin , Hur Jinyoung , Choi Sang Yoon 
Published: July 2022

AbstractVascular inflammation activated by pro-inflammatory cytokines is an inflammatory response that occurs in the early stages of atherosclerosis. Endothelial dysfunction in vascular inflammation begins with the expression of cell surface adhesion molecules by pro-inflammatory cytokines. The purpose of this study was to evaluate and verify the vascular inflammatory effects of isobavachalcone. In this study, we investigated the effects of isobavachalcone on inflammatory responses in vascular inflammation induced by the tumor necrosis factor-α (TNF-α) in human umbilical vein endothelial cells (HUVECs). TNF-α stimulation significantly increased the expression of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) proteins, and concentration-dependently decreased by isobavachalcone in HUVECs. Isobavachalcone suppressed TNF-α-induced ICAM-1 and VCAM-1 expression in HUVECs, thereby inhibiting TNF-α-induced increase in monocyte adhesion. In addition, isobavachalcone decreased the phosphorylation of the NF-κB (necrosis factor κB) p65 subunit. The findings of this study demonstrate that isobavachalcone prevents TNF-α-induced vascular inflammation and has the potential to protect against the early progression of atherosclerosis.
Research on risk factors of ischemic cerebrovascular disease in postmenopausal women based on the social-ecological model
Authors: Yang Chun-Jun , Wang Dong-Mei , Wang Tong , Song Ying 
Published: July 2022

Abstract
Objective
Based on the social-ecological model, this study aimed to comprehensively explore factors affecting the risk of ischemic cerebrovascular disease (ICVD) in postmenopausal women to provide theoretical bases for further prevention and intervention for postmenopausal women.

Methods
Postmenopausal women who underwent medical examinations in one health-checkup agency in Tianjin from May 2015 to October 2015 were enrolled in this study. The ICVD 10-year Risk Assesment Form developed by the research team of the National "Tenth Five-Year Plan" research project was used to assess the factors affecting the risk of ICVD. Based on the social-ecological model, multiple types of scales, including physical activities, depression, Type D personality, social supports, and environment score, were used to comprehensively explore the factors associated with ICVD in postmenopausal women.

Results
300 valid questionnaires were obtained, with an effective rate of 92.0%. The subjects aged 44–74 years, with the average age of 62.06 ± 7.09 years. Among them, 58.67% of the subjects only obtained high-school diploma, 32.67% obtained college or university diploma, 90.33% were retirees, 95.33% were married, 92.33% experienced the natural menopause, 93.33% lived in urban or suburban areas, and 1.00% had a history of breast cancer. Multivariate logistic regression analysis suggested that monthly income (¥), parity, exposure to second-hand or third-hand smoke, easy access to healthy food, physical activities, depression, Type D personality, social support and environmental factors were associated with the risk of ICVD in postmenopausal women (P < 0.05). Among them, easy access to healthy food (OR = 0.242), social support (OR = 0.861) and environmental factors (OR = 0.866) were protective factors from ICVD. OR < 1 indicates that the exposure factor is negatively correlated with the disease, and the exposure factor has a protective effect on preventing the occurrence of the disease. Parity (OR = 3.795), exposure to second-hand or third-hand smoke (OR = 2.886), depression (OR = 1.193), and Type D personality (OR = 1.148) were risk factors of ICVD. OR > 1 means that the exposure factor is positively correlated with the disease, and the exposure factor increases the risk of disease occurrence.

Conclusions
For postmenopausal women, in the future, in addition to prevention and management of the conventional risks, the conditions of their mentality and social support should be paid attention to, at the same time, and if they can, try to choose a good community environment to live in, which could better reduce the incidence and mortality of ICVD in postmenopausal women.
Testing planetary urbanisation: Siberia’s trans-scalar spatial regime of oil production
Authors: Salgueiro Barrio Roi , O’Shea Conor 
Published: July 2022

AbstractThis paper analyses the extended urbanization of oil production in Siberia in order to test Neil Brenner and Christian Schmid’s theory of planetary urbanization. According to these authors, the intensification of the urban process triggered by the consolidation of global neoliberalism since the early 1990s, has transformed the planet into a situation of total urbanization. In their view, this planetary condition can be measured by the incorporation of former remote wilderness such as the Amazon, the oceans, the deserts or Siberia within urban circuits of production (which they label under the notion of extended urbanization). In this article we test if Brenner and Schmid’s hypothesis applies to the Siberian case. With that goal, we develop a diachronic historic and cartographic analysis which shows first the incorporation of Siberia to the Russian Empire, second the consolidation of East Asia-Russia commercial circuits, and third the conceptualization of Siberia as primarily an area for resource extraction. Such analysis leads us to define three historic spatial regimes for the whole Siberia, the last of which we study in relation to the notion of planetary urbanization. Our study compares the geographies of oil production in the region first during the Soviet period, and then, following Brenner and Schmid’s chronology, after the 1990s. The article concludes that the latter phase certainly implies an unprecedented intensification of extended urbanization and the incorporation of Siberia into trans-scalar global circuits of production. Finally, in order to analyse the relation between this process and the consolidation of neoliberalism we develop a synchronic study and mapping of the operations of two oil companies: a public one, NOC ROSNEFT, and a private one, LUKOIL. We conclude that both are similarly invested in creating the trans-scalar geographies of uneven development that characterize neoliberalism.
Is a new generation of mycotoxin clay adsorbents safe in a pig’s diet?
Authors: Horky Pavel , Nevrkla Pavel , Kopec Tomas , Bano Iqra , Skoric Misa , Skladanka Jiri , Skalickova Sylvie 
Published: July 2022

Abstract
Background
Bentonites, as a clay mineral, serve in pig farms as adsorbents of toxic substances. They are mainly used to reduce the negative impact of mycotoxins to maintain the performance and health status of animals. The new genotypes of pigs are highly sensitive to a range of antinutrients, including mycotoxins. Currently, attention is focused on more effective adsorbents of mycotoxins with a higher adsorption capacity. Such materials are in great demand among feed manufacturers. However, there is a concern that these new materials may also adsorb too many essential nutrients and decrease animal performance. The aim of the experiment was to evaluate the effect of the new generation of purified bentonites on the efficiency and health status of the pigs.

Results
Forty-eight slaughtered pigs with an average weight of 31.2 ± 2.6 kg were included in the experiment. The pigs were divided into two groups (2 × 24 pigs). Pigs were slaughtered at an average weight of 66.3 ± 5.2. The first group had a diet without clay (control—C). The second group (treatment—T) was fed a diet with a clay additive (purified bentonite) of 1.5 kg/t. Animals were fed the experimental diet for 35 days. In group T, a higher daily weight gain (by 4.8%) and feed intake (by 2.9%) was observed while the feed conversion decreased by 1.9%. There were no significant differences between the groups of pigs during observation in the evaluation of hematological, biochemical parameters of the blood. Morpho-pathological analysis of the jejunum showed similar signs of moderate lymphoplasmacytic infiltrate in the mucosa in the groups C and T, contained similar number of goblet cells.

Conclusion
Taken together, the addition of the new generation of bentonite clays did not negatively influence the health status and the performance of pigs.
Prevalence and fluoroquinolone resistance of Campylobacter spp. isolated from beef cattle in Japan
Authors: Sasaki Yoshimasa , Asakura Hiroshi , Asai Tetsuo 
Published: July 2022

AbstractBeef is a source of human Campylobacter infections. Antimicrobial treatment is needed when patients are immunocompromised or have other comorbidities. Therefore, we investigated the prevalence and antimicrobial resistance of Campylobacter spp. in beef cattle in Japan. Rectal swab samples were collected from 164 beef cattle at an abattoir between March 2021 and August 2021, and Campylobacter spp. were isolated from 94 (57.3%) cattle. C. jejuni and C. coli were isolated from 68 and 26 cattle, respectively. For Campylobacter jejuni, the resistant rates against ampicillin, tetracycline and ciprofloxacin were 20.6, 75.0 and 64.7%, respectively. For C. coli, the resistant rates against ampicillin, tetracycline and ciprofloxacin were 53.8, 76.9 and 88.5%, respectively. No Campylobacter isolates were resistant to erythromycin. By multilocus sequence typing, C. jejuni and C. coli isolates were classified into 22 and 2 sequence types (STs). The top three STs of C. jejuni were ST806 (12 isolates), ST21 (nine isolates), and ST459 (eight isolates). The most frequent ST of C. coli was ST1068 (23 isolates). The results suggest that Campylobacter spp. are prevalent in the gastrointestinal tract of beef cattle slaughtered at abattoirs. Furthermore, the administration of erythromycin is effective against human campylobacteriosis caused by beef consumption. Monitoring the prevalence and antimicrobial resistance of Campylobacter spp. in beef cattle could be useful for managing the risk of human campylobacteriosis.
Regulatory T Cell Proportion and Phenotype Are Altered in Women Using Oral Contraception
Authors: Moldenhauer Lachlan M , Jin Min , Wilson Jasmine J , Green Ella S , Sharkey David J , Salkeld Mark D , Bristow Thomas C , Hull M Louise , Dekker Gustaaf A , Robertson Sarah A 
Published: July 2022

AbstractRegulatory T (Treg) cells are a specialized CD4+ T cell subpopulation that are essential for immune homeostasis, immune tolerance, and protection against autoimmunity. There is evidence that sex-steroid hormones estrogen and progesterone modulate Treg cell abundance and phenotype in women. Since natural oscillations in these hormones are modified by hormonal contraceptives, we examined whether oral contraception (OC) use impacts Treg cells and related T cell populations. T cells were analyzed by multiparameter flow cytometry in peripheral blood collected across the menstrual cycle from healthy women either using OC or without hormonal contraception and from age-matched men. Compared to naturally cycling women, women using OC had fewer Treg cells and an altered Treg cell phenotype. Notably, Treg cells exhibiting a strongly suppressive phenotype, defined by high FOXP3, CD25, Helios, HLADR, CTLA4, and Ki67, comprised a lower proportion of total Treg cells, particularly in the early- and mid-cycle phases. The changes were moderate compared to more substantial differences in Treg cells between women and men, wherein women had fewer Treg cells—especially of the effector memory Treg cell subset—associated with more T helper type 1 (Th1) cells and CD8+ T cells and lower Treg:Th1 cell and Treg:CD8+ T cell ratios than men. These findings imply that OC can modulate the number and phenotype of peripheral blood Treg cells and raise the possibility that Treg cells contribute to the physiological changes and altered disease susceptibility linked with OC use.
Notch signaling determines cell-fate specification of the two main types of vomeronasal neurons of rodents
Authors: Katreddi Raghu Ram , Taroc Ed Zandro M. , Hicks Sawyer M. , Lin Jennifer M. , Liu Shuting , Xiang Mengqing , Forni Paolo E. 
Published: July 2022

ABSTRACT
The ability of terrestrial vertebrates to find food and mating partners, and to avoid predators, relies on the detection of chemosensory information. Semiochemicals responsible for social and sexual behaviors are detected by chemosensory neurons of the vomeronasal organ (VNO), which transmits information to the accessory olfactory bulb. The vomeronasal sensory epithelium of most mammalian species contains a uniform vomeronasal system; however, rodents and marsupials have developed a more complex binary vomeronasal system, containing vomeronasal sensory neurons (VSNs) expressing receptors of either the V1R or V2R family. In rodents, V1R/apical and V2R/basal VSNs originate from a common pool of progenitors. Using single cell RNA-sequencing, we identified differential expression of Notch1 receptor and Dll4 ligand between the neuronal precursors at the VSN differentiation dichotomy. Our experiments show that Notch signaling is required for effective differentiation of V2R/basal VSNs. In fact, Notch1 loss of function in neuronal progenitors diverts them to the V1R/apical fate, whereas Notch1 gain of function redirects precursors to V2R/basal. Our results indicate that Notch signaling plays a pivotal role in triggering the binary differentiation dichotomy in the VNO of rodents.
An Evolutionary Analysis of the Development of the One North Innovation District in Singapore
Authors: Wong Poh Kam 
Published: July 2022

First conceptualised in Singapore’s first National Technology Plan in 1991, the idea of creating a new integrated R&D and innovation hub in Singapore languished until it was incorporated into a broader Technopreneurship 21 (T21) strategy announced in 1998, and was officially launched in late 2001. In the 20 years since, the innovation district has made significant development progress, but not quite in the manner as presented in a number of prior studies that have adopted a “top-down rational planning” narrative. Taking an evolutionary view, we argue that the actual development of One-North was significantly shaped by a number of critical actors as well as external environmental factors, and its evolutionary trajectory deviated from its original plan. Our evolutionary narrative provides insights on the role of champions in large scale innovation projects, and the need to integrate physical space development within a comprehensive innovation ecosystem development strategy.
L’espace vide: Phénoménologie et chorégraphie, Elsa Ballanfat (2021)
Authors: Basselier Laetitia 
Published: July 2022

Review of: L’espace vide: Phénoménologie et chorégraphie, Elsa Ballanfat (2021)
Bucharest: Zeta Books, 459 pp.,
ISBN 978-6-06967-132-4, p/bk, €24.00
NOVOS MEDICAMENTOS PARA A HEPATITE C: CARACTERIZAÇÃO DOS USUÁRIOS E RESULTADOS TERAPÊUTICOS
Authors: Cardoso Amanda dos Santos Teles , Costa Patrícia dos Santos , Dias Valdinéa Santos , Da Silva Cinara Vasconcelos , Cazedey Edith Cristina Laignier 
Published: July 2022

Segundo a Organização Mundial da Saúde, mais de 170 milhões de pessoas estão infectadas com o vírus da hepatite C (HCV). Os fármacos antivirais de ação direta revolucionaram o tratamento da hepatite C. A avaliação do perfil destes novos tratamentos pode fornecer informações relativas à sua efetividade. O presente trabalho teve como objetivo caracterizar o perfil clínico e descrever os aspectos epidemiológicos e demográficos de portadores do HCV tratados com sofosbuvir, daclatasvir, simeprevir e ribavirina, atendidos por Plano de Assistência à Saúde Suplementar do Estado da Bahia (PLANSERV), em 2015 e 2016. O desenho deste estudo foi observacional transversal e descritivo com análise de dados secundários obtidos por meio do banco de dados do PLANSERV. O perfil epidemiológico do estudo esteve alinhado com outros trabalhos da literatura, exceto pela predominância do sexo feminino (58%) com faixa etária de 60 anos ou mais. O perfil clínico demonstrou que os resultados terapêuticos com os novos fármacos foram positivos. A maioria dos pacientes finalizou o tratamento (64%), ainda que com grau de fibrose avançada, em 12 semanas e com baixo índice de reações adversas. De maneira geral, este trabalho indicou que o tratamento foi bem tolerado entre os portadores de hepatite C, fortalecendo a segurança no uso destes medicamentos e a necessidade de formas que ampliem o acesso à terapia.
Certain topics in ellipsometric data modeling with splines: a review of recent developments
Authors: Likhachev Dmitriy V. 
Published: July 2022

AbstractDielectric function representation by a variety of polynomial spline functions provides a consistent and efficient method for accurate modeling of the material optical properties in the context of spectroscopic ellipsometry data interpretation. Splines as an elegant and purely mathematical way for such modeling task were introduced about three decades ago. In the following years the use of splines in the area of ellipsometric data analysis became widely utilized. The goal of this review is to provide a self-contained presentation on the current status of the dielectric function modeling by splines for advanced industrial ellipsometry users but, hopefully, it can be useful for some scholarly users as well. It is also intended to promote more extended recognition of the spline-based modeling among optical metrology professionals. Here, a brief description of different ways, – ordinary polynomials, piecewise polynomials (splines), and B(asis)-spline functions, – is presented to parameterize an arbitrary function which can be used as an analytic representation of the dielectric-function curves. A number of particular polynomial-based models for the optical functions of materials and how they may be used in applications are also discussed. Particular attention is paid to different concepts of the efficient and optimal spline construction.