bluuebunny/crossref_metadata_2025_split huggingface dataset:
Justice and Inclusiveness: The Reconfiguration of Global–Local Relationships in Sustainability Initiatives in Ghana’s Cocoa Sector
Authors: Obeng Adomaa Faustina , Vellema Sietze , Slingerland Maja 
Published: November 2022

AbstractPressure from the public and non-governmental organisations is pushing lead companies in the cocoa and chocolate sectors towards becoming more environmentally sustainable and socially just. Because of this, several sustainability programmes, certification schemes and delivery initiatives have been introduced. These have changed the relationship between chocolate companies, cocoa exporters, and small-scale farmers. This paper observes how large companies in the cocoa export and consumer markets are shifting away from their traditionally remote position in the cocoa sector. The pressure to ensure sustainability and justice has provoked more mutually dependent relationships with cocoa producers. Our analysis outlines the implications this emerging reconfiguration of global-local relationships has for procedural justice principles of interdependence and refutability, and the distributive justice principles of need and equity. These principles are important because they enable the different dimensions of inclusion: ownership, voice, risk, and reward. This paper highlights and qualifies arrangements surrounding these justice principles that manifest in the way five service delivery initiatives - associated with sustainability programmes and led by major buying companies in Ghana’s cocoa sector – are implemented. We show inclusiveness as an outcome of dynamic global-local relationships that are constantly reworked in response to smallholder farmers’ agency and state regulations. Portraying inclusiveness as an outcome of interactions changes its conceptualisation from a predefined ethical standpoint included in the design of standards to a result of unfolding mutual dependencies, which refashion how inclusive agriculture value chains work.
Efficient smooth minorants for global optimization of univariate functions with the first derivative satisfying the interval Lipschitz condition
Authors: Posypkin Mikhail A. , Sergeyev Yaroslav D. 
Published: November 2022

AbstractIn 1998, the paper Sergeyev (Math Program 81(1):127–146, 1998) has been published where a smooth piece-wise quadratic minorant has been proposed for multiextremal functions f(x) with the first derivative $$f'(x)$$

f
′

(
x
)

satisfying the Lipschitz condition with a constant L, i.e., $$f'(x)$$

f
′

(
x
)

cannot increase with the slope higher than L and decrease with the slope smaller than $$-L$$

-
L

. This minorant has been successfully applied in several efficient global optimization algorithms and used in engineering applications. In the present paper, it is supposed that the first derivative $$f'(x)$$

f
′

(
x
)

cannot increase with the slope higher than a constant $$\beta $$
β
and decrease with the slope smaller than $$\alpha $$
α
. The interval $$[\alpha ,\beta ]$$

[
α
,
β
]

is called the Lipschitz interval (clearly, in this case the Lipschitz constant $$L = \max \{|\alpha |, |\beta | \}$$

L
=
max
{
|
α
|
,
|
β
|
}

). For this class of functions, smooth piece-wise estimators (minorants and majorants) have been proposed and applied in global optimization. Both theoretically and experimentally (on 200 randomly generated test problems) it has been shown that in cases where $$ |\alpha | \ne |\beta |$$

|
α
|
≠
|
β
|

the new estimators can give a significant improvement w.r.t. those proposed in Sergeyev (Math Program 81(1):127–146, 1998), for example, in the framework of branch-and-bound global optimization methods.
Reps and representations: a warm-up to a grammar of lifting
Authors: Esipova Maria 
Published: November 2022

AbstractIn this paper, I outline a grammar of lifting (i.e., resistance training) and compare it to that of language. I approach lifting as a system of generating complex meaning–form correspondences from regularized elements and describe the levels of mental representations and relationships between them that are involved in full command of this system. To be able to do so, I adopt a goal-based conception of meaning, which allows us to talk about mappings from complex goals to complex surface outputs in systems of intentional action, signaling and non-signaling, interactive and non-interactive, in a unified way, and show how it applies in lifting. I then proceed to argue that the grammar of lifting is architecturally very similar to that of language. First, I show that both involve stable (idiomatized/lexicalized) pairings of regularized forms with regularized meanings. Second, I argue that in both lifting and language, meaning–form mapping is mediated by syntax, which, crucially, operates on non-linearized hierarchical structures of abstract objects that include both content morphemes and functional morphemes. I conclude, following and expanding on some insights from prior literature and offering further evidence for them, that neither of these architectural phenomena (idiomatized meaning–form pairings and abstract syntax) is specific to language, with both of them likely emerging in skilled action that does not necessarily involve social interaction, due to considerations of repeatability and reusability of elements in new contexts.
Improving urban seismic risk estimates for Bishkek, Kyrgyzstan, through incorporating recently gained geological knowledge of hazards
Authors: Amey Ruth M. J. , Elliott John R. , Watson C. Scott , Walker Richard , Pagani Marco , Silva Vitor , Hussain Ekbal , Abdrakhmatov Kanatbek E. , Baikulov Sultan , Tilek Kyzy Gulkaiyr 
Published: November 2022

AbstractMany cities are built on or near active faults, which pose seismic hazard and risk to the urban population. This risk is exacerbated by city expansion, which may obscure signs of active faulting. Here, we estimate the risk to Bishkek city, Kyrgyzstan, due to realistic earthquake scenarios based on historic earthquakes in the region and an improved knowledge of the active fault sources. We use previous literature and fault mapping, combined with new high-resolution digital elevation models to identify and characterise faults that pose a risk to Bishkek. We then estimate the hazard (ground shaking), damage to residential buildings and distribution of losses (economical cost and fatalities) using the Global Earthquake Model OpenQuake engine. We model historical events and hypothetical events on a variety of faults that could plausibly host significant earthquakes. This includes proximal, recognised, faults as well as a fault under folding in the north of the city that we identify using satellite DEMs. We find that potential earthquakes on faults nearest to Bishkek—Issyk Ata, Shamsi Tunduk, Chonkurchak and the northern fault—would cause the most damage to the city. An Mw 7.5 earthquake on the Issyk Ata fault could potentially cause 7900 ± 2600 completely damaged buildings, a further 16,400 ± 2000 damaged buildings and 2400 ± 1500 fatalities. It is vital to properly identify, characterise and model active faults near cities to reduce uncertainty as modelling the northern fault as a Mw 6.5 instead of Mw 6.0 would result in 37% more completely damaged buildings and 48% more fatalities.
Price indicators for Airbnb accommodations
Authors: Contu Giulia , Frigau Luca , Conversano Claudio 
Published: November 2022

AbstractNew forms of hospitality grew increasingly more popular and successful during the last decades. Nowadays, they are chosen for different reasons, one of the most important certainly being price. Understanding the elements that can impact on price determination is crucial to increase profitability. We propose two price indicators for Airbnb accommodations, which are defined in three phases using proportional odds model as a reference model. The first phase focuses on the probability estimation of accommodations belonging to a specific class of price. The second phase aims to evaluate the ability of the model to make good predictions by computing three different indexes. Finally, the three indexes are combined to define the indicators q and r which evaluate, respectively, the impact that six different dimensions (transports, culture, crowd, property, management, and time) have with respect to price determination on Airbnb accommodations and their relative importance concerning neighborhoods. The analysis is focused on 61 neighborhoods of Rome. The findings show differences with respect to the impact of the dimensions on price for each neighborhood of Rome.
Health-related quality of life in patients newly diagnosed with prostate cancer: CAPLIFE study
Authors: Lozano-Lorca Macarena , Barrios-Rodríguez Rocío , Redondo-Sánchez Daniel , Cózar José-Manuel , Arrabal-Martín Miguel , García-Caballos Marta , Salcedo-Bellido Inmaculada , Sánchez María-José , Jiménez-Moleón José-Juan , Olmedo-Requena Rocío 
Published: November 2022

Abstract
Purpose
To analyse the Health-Related Quality of Life (HRQoL) at diagnosis of patients with prostate cancer (PCa) according to tumour extension and urinary symptomatology and to explore factors associated with HRQoL.

Methods
408 Controls and 463 PCa cases were included. Eligibility criteria were a new diagnosis of PCa (cases), 40–80 years of age, and residence in the participating hospitals’ coverage area for ≥ 6 months before recruitment. HRQoL was evaluated using the 12-Item Short-Form Health Survey, Mental (MCS) and Physical Component Summaries (PCS), and urinary symptoms with the International Prostate Symptom Score. HRQoL scores for all PCa cases, according to tumour extension and urinary symptoms, were compared with controls. In addition, information about lifestyles and comorbidities was collected and its association with low HRQoL (lower scores) were explored using logistic regression models.

Results
Overall cases had similar PCS score, but lower MCS score than controls. The lowest standardised scores for both PCS and MCS were reached by cases with severe urinary symptoms and a metastatic tumour [mean (SD); PCS: 41.9 (11.5), MCS: 42.3 (10.3)]. Having “below” PCS and MCS scores was associated with the presence of three or more comorbidities in the cases [aOR = 2.86 (1.19–6.84) for PCS and aOR = 3.58 (1.37–9.31) for MCS] and with severe urinary symptomatology [aOR = 4.71 (1.84–12.08) for PCS and aOR = 7.63 (2.70–21.58) for MCS].

Conclusion
The mental dimension of HRQoL at diagnosis of patients with PCa was lower than in controls, especially for cases with severe urinary symptoms and a metastatic tumour. Comorbidities and urinary symptoms were variables associated with the HRQoL of PCa cases.
Interactions Between Imbibition and Pressure-Driven Flow in a Microporous Deformed Limestone
Authors: Lewis Helen , Couples Gary , Tengattini Alessandro , Buckman Jim , Tudisco Erika , Etxegarai Maddi , Viggiani Gioacchino , Hall Stephen A. 
Published: November 2022

AbstractNeutron imaging is used for direct observation of evolving water–air and deuterated water–normal water exchanges in flow experiments performed on a laboratory-deformed, microporous laminated limestone, an extremely fine-textured rock altered by arrays of superposed fractures generated in a rock mechanics apparatus. The neutron images document significant, evolving, water speed and flow direction variability at the deci-micron scale and spatially complex patterns of both increasing and decreasing water saturation. We infer that capillarity-driven and pressure-driven water movement occurs concurrently, in close proximity and in competition, and that as local and global water saturations evolve these two drivers can change their dominance in both matrix and deformed elements. Thin sections are used to obtain sub-micron resolution SEM images that provide multi-scale information on the textural features’ spatial arrangements. The textural characteristics are consistent with the inferences made from the coarser flow imaging. Alternating lamina types provide the primary lithological heterogeneity, while the experimentally created deformations lead to quasi-planar zones of highly comminuted matrix and fracture-like voids, each with lengths ranging from sub-mm to cm. Together deformation features delineate a partially connected array. The interplay between fluid movement through deformation features, and flow into (and out of) the laminae, implies near-equivalence of local driving pressure- and capillary-related energies, with subtle shifts in this balance as water saturation increases. The insights gained invite a re-examination of common rules-of-thumb for multi-phase fluid flow often adopted in fractured, low-permeability microporous rocks.
RHDV 3C protein antagonizes type I interferon signaling by cleaving interferon promoter stimulated 1 protein
Authors: Men Yanjuan , Wang Yonghui , Wang Hui , Zhang Maoyin , Liu Jing , Chen Yang , Han Xufeng , Chen Renjin , Chen Quangang , Hu Ankang 
Published: November 2022

AbstractThe host innate immune response to viral infection often involves the activation of type I interferons. Not surprisingly, many viruses have evolved various mechanisms to disable the interferon pathway and evade the antiviral response involving innate immunity. Rabbit hemorrhagic disease (RHD) is caused by RHD virus (RHDV), but whether it can antagonize the production of host interferon to establish infection has not been investigated. In this study, we found that during RHDV infection, the expressions of interferon and the interferon-stimulated gene were not activated. We constructed eukaryotic expression plasmids of all RHDV proteins, and found that RHDV 3C protein inhibited poly(I:C)-induced interferon expressions. Using siRNA to interfere with the expressions of TLR3 and MDA5, we found that the MDA5 signal pathway was used by the 3C protein to inhibit poly(I:C)-induced interferon expression. This effect was mediated by cleaving the interferon promoter stimulated 1 (IPS-1) protein. Finally, our study showed that interferon was effective against RHDV infection. In summary, our findings showed that the RHDV 3C protein was a new interferon antagonist. These results increase our understanding of the escape mechanism from innate immunity mediated by the RHDV 3C protein.
Cultivating Salix Viminalis in Agricultural-Riparian Transition Areas to Mitigate Agriculturally Derived N2O Emissions from Potato Cropping Systems on Prince Edward Island
Authors: Wilts Holly D. M. , Burton David L. , Farooque Aitazaz A. 
Published: November 2022

AbstractCultivating shrub willow (Salix viminalis) in agricultural-riparian transition areas has been proposed as a strategy for mitigating elevated riparian nitrous oxide (N2O) emissions in agricultural regions. Nitrogen-based fertilizers are water soluble, enter riparian areas through surface runoff and subsurface lateral flow, and are converted to N2O by incomplete anaerobic denitrification. Salix buffer strips can intercept and recycle fertilizer nitrate (NO3−) into their biomass and/or promote complete denitrification, reducing N2O emissions. We investigated the impact of Salix viminalis buffers on N2O emissions relative to grassed buffers and upslope cultivated fields in potato rotations at 5 research sites across Prince Edward Island (PEI), Canada. Greenhouse gas (N2O, CO2, CH4) flux at the soil-atmosphere interface was measured using non-steady-state static chambers in 2018 and 2019. NO3− exposure, soil temperature, and soil moisture content were quantified. Agricultural-riparian Salix significantly reduced N2O emissions even when high NO3− inputs occurred and following precipitation events. Mean cumulative seasonal reductions of 1.32 kg N2O–N ha−1 (− 0.02 to 6.16 kg N2O–N ha−1) were observed in Salix relative to cultivated fields; however, they were not significantly different than grass. The mean cumulative average global warming potential of Salix was 613 kg CO2e ha−1 lower than cultivated fields, with reductions of up to 2918 kg CO2e ha−1. Differences in N2O flux between vegetation types were the greatest influencing factor. No hot moments of N2O emission were observed in Salix following high rainfall events, which coincided with up to 95% decreases in N2O emissions in Salix relative to cultivated fields.
Explorers of the twenty-first century? A systematic literature review of the scholarship on international entrepreneurs from developed economies
Authors: Scheu Maximilian , Kuckertz Andreas 
Published: November 2022

AbstractThroughout history, expeditionists and explorers have discovered foreign countries and new worlds, markedly influencing the lives of succeeding generations. However, as multinational enterprises have come to drive globalisation, the existence of entrepreneurial individuals without the resources of large corporations is a relatively recent phenomenon. Although research on migrant entrepreneurs demonstrates the positive impact that foreign entrepreneurial activity can have on job creation and innovation, a clear perspective on entrepreneurs from developed economies venturing abroad is lacking. The study aggregates evidence from 33 articles to establish a unifying framework that describes the foreign entrepreneurial process originating in developed economies. The framework proposes categorising foreign entrepreneurial activity according to social and economic dimensions and introduces four archetypes of foreign entrepreneurs, helping us understand the dynamics of the institutional context and the motivations for venturing into foreign environments. Finally, the study discusses the implications for foreign entrepreneurs and considers future research avenues.
Leading with a cool head and a warm heart: trait-based leadership resources linked to task performance, perceived stress, and work engagement
Authors: Dåderman Anna Maria , Kajonius Petri Juhani , Hallberg Angela , Skog Sandra , Hellström Åke 
Published: November 2022

AbstractLeaders of today need to achieve well in terms of task performance, perceiving low stress, and having high levels of work engagement. One may ask whether trait-based leadership resource factors can be identified and how such resource factors might relate to task performance, perceived stress, and work engagement. Our aim was to test the hypothesis, derived from Hobfoll’s motivational Conservation of Resources (COR) theory, that there are trait-based leadership resource factors, which are differentially correlated to the leaders’ task performance, perceived stress, and work engagement. Leaders (N = 344) aged from 23 to 65 years (M = 49, SD = 8.6; 58% women) completed an online questionnaire including measures of task performance, perceived stress, work engagement, personality traits, trait emotional intelligence, empathy, performance-related self-esteem, compassionate and rational leadership competence, and coping resources for stress. Using exploratory factor analysis, we identified four trait-based leadership resource factors. With Bonferroni adjustment, and controlling for sex, age, number of years in the current managerial position, self-deceptive enhancement, and impression management, only Rational Mastery was significantly positively correlated with task performance. Rational Mastery, Efficient Coping, and Modesty were negatively correlated with perceived stress, and all factors except Modesty, but including the fourth (Good-Heartedness) were positively correlated with work engagement. Organizations striving for sustainable work conditions should support trait-based leadership, which depends not only on a task-oriented resource such as rational mastery, but also on human-oriented resources such as efficient coping, modesty, and good-heartedness, all of them being differentially related to task performance, perceived stress, and work engagement.
PD-1-CD28 fusion protein strengthens mesothelin-specific TRuC T cells in preclinical solid tumor models
Authors: Lesch Stefanie , Nottebrock Alessia , Rataj Felicitas , Heise Constanze , Endres Stefan , Kobold Sebastian 
Published: November 2022

Abstract
Background
T cell receptor fusion constructs (TRuC) consist of an antibody-based single chain variable fragment (scFv) fused to a T cell receptor chain (TCR) and allow recognition of cancer cells in an HLA-independent manner. Unlike chimeric antigen receptors (CAR), TRuC are integrated into the TCR complex resulting in a functional chimera with novel specificity, whilst retaining TCR signaling. To further enhance anti-tumor function, we expressed a PD-1-CD28 fusion receptor in TRuC T cells aiming to prevent tumor-induced immune suppression and T cell anergy.

Methods
The activation level of engineered T cells was investigated in co-culture experiments with tumor cells followed by quantification of released cytokines using ELISA. To study T cell-mediated tumor cell lysis in vitro, impedance-based real-time tumor cell killing and LDH release was measured. Finally, two xenograft mouse cancer models were employed to explore the therapeutic potential of engineered T cells.

Results
In co-culture assays, co-expression of PD-1-CD28 enhanced cytokine production of TRuC T cells. This effect was dependent on PD-L1 to PD-1-CD28 interactions, as blockade of PD-L1 amplified IFN-γ production in unmodified TRuC T cells to a greater level compared to TRuC-PD-1-CD28 T cells. In vivo, PD-1-CD28 co-expression supported the anti-tumor efficacy of TRuC T cells in two xenograft mouse cancer models.

Conclusion
Together, these results demonstrate the therapeutic potential of PD-1-CD28 co-expression in TRuC T cells to prevent PD-L1-induced T cell hypofunction.
Early Maladaptive Schemas and Mental Disorders in Adulthood: a Systematic Review and Meta-analysis
Authors: Thimm Jens C. , Chang Michelle 
Published: November 2022

AbstractEarly maladaptive schemas (EMSs) are broad and pervasive themes regarding oneself and one’s relationships with others originating from adverse childhood experiences. Although the concept of EMSs was initially developed for the treatment of personality disorders, the associations of EMSs with a variety of other mental disorders have been investigated. The goal of the present study was to summarize and analyze the EMSs-disorder associations in studies in which patients with specific psychiatric diagnoses were compared to healthy controls. Of the 28 studies that met the inclusion criteria, 27 were included in a meta-analysis. Across diagnoses, all EMSs were elevated in the clinical groups. The largest effect sizes were observed for the social isolation, the negativity/pessimism, the defectiveness/shame, and social undesirability schemas. Depression (n = 8), borderline personality disorder (n = 5), and obsessive–compulsive disorder (n = 5) were the most frequently studied mental disorders. Heterogeneity between studies was high. Results suggest that mental disorders are not characterized by specific EMSs.