bluuebunny/crossref_metadata_2025_split huggingface dataset:
A viewpoint describing the American Society of Transplantation rationale to conduct a comprehensive patient survey assessing unmet immunosuppressive therapy needs
Authors: Taber David J. , Gordon Elisa J. , Jesse Michelle T. , Myaskovsky Larissa , Peipert John Devin , Jaure Allison , George Roshan , Fitzsimmons William ,   for the American Society of Transplantation Board of Directors
Published: December 2022

AbstractThis viewpoint aims to “set the stage” and provide the rationale for the proposed development of a large‐scale, comprehensive survey assessing transplant patients’ perceived unmet immunosuppressive therapy needs. Research in organ transplantation has historically focused on reducing the incidence and impact of rejection on allograft survival and minimizing or eliminating the need for chronic immunosuppressive therapies. There has been less emphasis and investment in therapies to improve patient‐reported outcomes including health‐related quality of life and side‐effects. Patient‐focused drug development (PFDD) is a new and important emphasis of the Food and Drug Administration (FDA) that provides a guiding philosophy for incorporating the patient experience into drug development and evaluation. The American Society of Transplantation (AST) Board of Directors commissioned this working group to prepare for the conduct of a comprehensive patient survey assessing unmet immunosuppressive therapy needs. This paper aims to describe the basis for why it is important to conduct this survey and briefly outline the plan for broad stakeholder engagement to ensure the information gained is diverse, inclusive, and relevant for advancing PFDD in organ transplant recipients.
Development of children, adolescents, and young adults with cerebral palsy according to the ICF: A scoping review
Authors: Chagas Paula S. C. , Magalhães Elton D. D. , Sousa Junior Ricardo R. , Romeros Angélica C. S. F. , Palisano Robert J. , Leite Hércules R. , Rosenbaum Peter 
Published: December 2022

AbstractAimTo identify and provide a descriptive overview of the development of children, adolescents, and young adults with cerebral palsy (CP) in longitudinal studies; and map areas of focus according to the components of the World Health Organization's International Classification of Functioning, Disability, and Health (ICF).MethodLongitudinal studies of the development of children, adolescents, and/or young adults with CP were included in this scoping review. A search for eligible studies was conducted in the databases MEDLINE, PubMed, LILACS, EMBASE, Cochrane, CINAHL, and Scopus, and was restricted to the years 2002 to 2022. All outcome measures of the studies were classified into ICF components.ResultsIn the 56 studies included, there were 19 438 participants, involving mainly children, followed by adolescents, and lastly young adults. All components of the ICF were investigated and many studies reported outcomes in more than one component. Activity was the most investigated (67.9%; n = 38 studies), followed by body functions and structures (42.9%; n = 24 studies). Participation (14.2%; n = 8 studies) and environmental factors (3.6%; n = 2 studies) were the least studied. None of the studies investigated personal factors as an outcome.InterpretationThis scoping review provides an overview of studies on the development of children, adolescents, and young adults with CP, using the ICF framework, identifying current areas of focus and gaps in the research. Future studies should target participation, contextual factors, and the transition into adulthood.What this paper adds

The International Classification of Functioning, Disability, and Health can be used to map a range of outcomes through developmental studies.
The main outcomes investigated in children with cerebral palsy were activity, and body functions and structures.
Little has been explored in participation and contextual factors outcomes over time.
The main classification used to stratify the participants was the Gross Motor Function Classification System.
Clinical adult outcome 11–30 years after pediatric epilepsy surgery: Complications and other surgical adverse events, seizure control, and cure of epilepsy
Authors: Hoppe Christian , Beeres Kassandra , Witt Juri‐Alexander , Sassen Robert , Helmstaedter Christoph 
Published: December 2022

AbstractObjectivePediatric epilepsy surgery promises seizure freedom or even cure of epilepsy. We evaluated the long‐term (≥10 years) adult clinical outcome including surgery‐related adverse events and complications, which are generally underreported.MethodsA monocentric, single‐arm, questionnaire study in now adult patients who underwent epilepsy surgery during childhood. A novel ad hoc parental/patient questionnaire, which addressed diverse outcome domains was applied.ResultsFrom a total of 353 eligible patients, 203 could be contacted (3 patients died of causes unknown) and 101 (50%) returned appropriately filled‐in surveys. No evidence for a survey‐response bias was found. The rate of surgical complications according to the patient records was 9%. As regards the survey, half of the parents/patients reported surgical adverse events (expected and unexpected issues) and one‐third reported permanent aversive sequels. Two‐thirds of the patients were seizure‐free during the last year before follow‐up; 63% were Engel class 1A; favorable seizure outcomes (including auras only) were obtained in 73%; and 54% were seizure‐free and off antiseizure medicine (ASM), that is, cured of epilepsy. In non–seizure‐free patients, seizure relapse occurred at any time during the follow‐up interval but 87% of those with a seizure‐free first postoperative year were seizure‐free at follow‐up. One patient experienced a seizure relapse during the ASM withdrawal trial but became seizure‐free again with ASMs. Eleven patients reported an increased number of ASMs as compared to the time before surgery. Earlier focal surgery did not affect the long‐term clinical outcome.SignificancePediatric epilepsy surgery was capable of curing epilepsy in about one‐half of the children and to significantly control seizures in about three‐fourths. Long‐term success of focal surgery did not depend on age at surgery or duration of epilepsy. Surgical adverse events including complications may be underreported and must be assessed more thoroughly.
The anthropogenic effect of land use on population genetics of Malcus inconspicuus
Authors: Wang Shujing , Li Yanfei , Zhou Jiayue , Jiang Kun , Chen Juhong , Ye Zhen , Xue Huaijun , Bu Wenjun 
Published: December 2022

AbstractSince the beginning of the Holocene era, human activities have seriously impacted animal habitats and vegetative environments. Species that are dependent on natural habitats or with narrow niches might be more severely affected by habitat changes. Malcus inconspicuus is distributed in subtropical China and highly dependent on the mountain environment. Our study investigated the role of the mountainous landscape in the historical evolution of M. inconspicuus and the impact of Holocene human activities on it. A phylogeographical approach was implemented with integrative datasets including double‐digest restriction site‐associated DNA (ddRAD), mitochondrial data, and distribution data. Three obvious clades and an east–west phylogeographical pattern were found in subtropical China. Mountainous landscape has “multifaceted” effects on the evolutionary history of M. inconspicuus, it has contributed to population differentiation, provided glacial refuges, and provided population expansion corridors during the postglacial period. The effective population size (Ne) of M. inconspicuus showed a sharp decline during the Holocene era, which revealed a significantly negative correlation with the development of cropland in a hilly area at the same time and space. It supported that the species which are highly dependent on natural habitats might undergo greater impact when the habitat was damaged by agricultural activities and we should pay more attention to them, especially in the land development of their distribution areas.
The polyamorous threat to nonmarriage
Authors: Baker Katharine K. 
Published: December 2022

AbstractSome progressive U.S. Cities and several Canadian provinces now provide mechanisms for polyamorous families to register as such with state authorities. More than a million people in the United States identify as polyamorous and many more practice some form of ethical nonmonogamy. This article suggests that the growing recognition of polyamory poses a substantial threat to a simultaneous development in family law: the call by scholars and the Uniform Law Commission for courts to enforce a more implied contract, implied partnership and equitable claims in the context of non‐marital conjugal cohabitation. Non‐marital cohabitants argue that courts can infer marital‐type commitments to share property from the fact of conjugal cohabitation. They argue that their nonmarriage should entitle them to the kinds of relief afforded to divorcing couples. But polyamorous conjugal cohabitation involves very different norms and commitments to reliance, partnership and transparency than does traditional marriage. Marital‐type relief maps awkwardly, if at all, onto the reality of most polyamorous relationships. By bringing into relief that which we cannot necessarily assume about conjugal cohabitation, the recognition of polyamory questions what many proponents of more legal protection of nonmarital couples ask courts to assume about conjugal cohabitation, namely that it gives rise to reasonable reliance on a status quo and an intent to share property. Moreover, by providing a means for polyamorous households to register their relationships, polyamorous registration normalizes the idea of non‐marital relationship registration. The more normal and expected it is for people who want rights as some form of family to register their familial intent with the state, the harder it is for those who have not so registered to argue that the state must treat them as some sort of family.
Understanding factors influencing Atlantic herring (Clupea harengus) recruitment: From egg deposition to juveniles
Authors: Burbank Jacob , DeJong Rachel A. , Turcotte François , Rolland Nicolas 
Published: December 2022

AbstractRecruitment is a critical component of population dynamics and variability in recruitment underpins large fluctuations in population abundances of commercially valuable marine fishes. Marine pelagic fishes such as Atlantic herring (Clupea harengus) experience relatively high variability in recruitment that is driven by a wide range of biotic and abiotic factors. The relative importance and interaction of each factor for determining recruitment is poorly understood, and consequently, recruitment estimates are one of the largest uncertainties in fisheries management and predictions of future population sizes. Poor recruitment of Atlantic herring has been identified as a major issue and bottleneck for the species; therefore, factors influencing successful recruitment are of great interest to fisheries managers. Here we review studies that have examined the factors influencing survival at the egg stage, early larval stage, late larval stage, and juvenile stage to develop a more comprehensive understanding of the recruitment of Atlantic herring and provide recommendations to guide future research. We identified nine biotic and eight abiotic factors that have been found to substantially impact the recruitment of Atlantic herring, with temperature, prey availability, and predation being the most commonly investigated factors. We conclude it is not one factor that primarily determines recruitment, but rather a collection of many factors that vary temporally and spatially that drive the large variation observed in Atlantic herring recruitment year over year. A holistic approach is required to better understand recruitment and improve fisheries management decisions regarding Atlantic herring.
Unveiling the environmental drivers of intraspecific body size variation in terrestrial vertebrates
Authors: Henry Erin , Santini Luca , Huijbregts Mark A. J. , Benítez‐López Ana 
Published: December 2022

AbstractAimWhether intraspecific spatial patterns in body size are generalizable across species remains contentious, as well as the mechanisms underlying these patterns. Here we test several hypotheses explaining within‐species body size variation in terrestrial vertebrates including the heat balance, seasonality, resource availability and water conservation hypotheses for ectotherms, and the heat conservation, heat dissipation, starvation resistance and resource availability hypotheses for endotherms.LocationGlobal.Time period1970–2016.Major taxa studiedAmphibians, reptiles, birds and mammals.MethodsWe collected 235,905 body size records for 2,229 species (amphibians = 36; reptiles = 81; birds = 1,545; mammals = 567) and performed a phylogenetic meta‐analysis of intraspecific correlations between body size and environmental variables. We further tested whether correlations differ between migratory and non‐migratory bird and mammal species, and between thermoregulating and thermoconforming ectotherms.ResultsFor bird species, smaller intraspecific body size was associated with higher mean and maximum temperatures and lower resource seasonality. Size–environment relationships followed a similar pattern in resident and migratory birds, but the effect of resource availability on body size was slightly positive only for non‐migratory birds. For mammals, we found that intraspecific body size was smaller with lower resource availability and seasonality, with this pattern being more evident in sedentary than migratory species. No clear size–environment relationships were found for reptiles and amphibians.Main conclusionsWithin‐species body size variation across endotherms is explained by disparate underlying mechanisms for birds and mammals. Heat conservation (Bergmann's rule) and heat dissipation are the dominant processes explaining biogeographic intraspecific body size variation in birds, whereas in mammals, body size clines are mostly explained by the starvation resistance and resource availability hypotheses. Our findings contribute to a better understanding of the mechanisms behind species adaptations to the environment across their geographic distributions.
Construction of high density genetic map and quantitative trait locus mapping in a sorghum Tx623A × sudangrass S722 population
Authors: Tu Wenmiao , Wang Lihua , Jin Peng , Meng Ruirui , Zheng Jian , Liu Yanlong , Wang Yi‐Hong , Li Jieqin 
Published: December 2022

AbstractSorghum–sudanense is a hybrid of sorghum and Sudanese grass and is widely used in animal husbandry and aquaculture because of its high yield, excellent quality and wide adaptability. Using high‐throughput sequencing, we constructed a high‐density genetic map of sorghum Tx623A × sudangrass S722 with 103 recombinant inbred lines (RILs) in this study and mapped quantitative trait loci (QTLs) for plant height (PH), stem diameter (SD), tiller number (TN), fresh weight (FW) and dry weight per plant (DW). The map included 1610 markers with a total length of 2329 cM and QTL mapping identified 19 QTLs, including two for PH, three for SD, four for TN, four for FW and five for DW. We detected two QTL clusters containing overlapping QTLs for PH, FW and DW. Orthologs of three SD candidate genes from maize were found within two SD QTLs. The identification of these QTLs will be useful for cloning the corresponding genes for these traits and developing marker‐assisted selection (MAS) in future sorghum breeding programs.
Haemophilia A and B – evaluation of the Swedish prophylactic regimen by magnetic resonance imaging
Authors: Lundin Björn , Baghaei Fariba , Holmström Margareta , Petrini Pia , Müller Gunilla , Månsson Sven , Ljung Rolf 
Published: December 2022

AbstractIntroductionSweden has been a pioneer in the prophylactic treatment of haemophilia. Magnetic resonance imaging (MRI) can detect small changes in joints and can therefore give an indication of a risk of developing arthropathy.AimTo use MRI to evaluate the outcome of the Swedish ‘high‐dose regimen’ and correlate the findings to age, bleeds, joint score and physical activity.MethodsThe study group comprised 48 Swedish male patients, mean age 25 years (range 12–33 years), with severe or moderate haemophilia A or B. Data on the Haemophilia Joint Health Score (HJHS) were available and physical activity was evaluated by a self‐reported questionnaire.ResultsMRI score was recorded in 188 joints. Twenty out of 48 patients had a score of ≥1 (range 1–13) in 31 joints of which 3/31 scores were in the knees and 28/31 in the ankles. No correlation was found between the number of recorded bleeds and the MRI score or between HJHS and MRI score. There was no correlation between the physical activity and the number of joint bleeds per se, but a trend (OR 3.0) that those most physically active (19/48; 39.6%), more frequently had an MRI score of ≥1 with an overweight for the right ankle.ConclusionThe Swedish prophylactic model offers protection against haemophilia joint arthropathy but will still not prevent osteochondral changes in some patients at young age. MRI of the ankles can signal risk of future arthropathy and indicate need to modify the prophylactic regimen.
Novel markers in breast pathology
Authors: Dabbs David J , Huang Richard S , Ross Jeffrey S 
Published: December 2022

AbstractBreast pathology is an ever‐expanding database of information which includes markers, or biomarkers, that detect or help treat the disease as prognostic or predictive information. This review focuses on these aspects of biomarkers which are grounded in immunohistochemistry, liquid biopsies and next‐generation sequencing.
OPENING THE BLACK BOX OF INTERPRETATION: DIGITAL HISTORY PRACTICES AS MODELS OF KNOWLEDGE
Authors: SCHWANDT SILKE 
Published: December 2022

ABSTRACTDigital history is more than just the implementation of algorithmic and other data practices in the practice of history writing. It places our discipline under a microscope and enables us to focus in on what history writing is in the first place: writing about the past under specific social and societal conditions. This article argues for a closer look at the traditions of history writing in order to understand its principles and to determine what the digital condition contributes to historiography. Does the work of historians actually change in principle, or does digital history instead reflect the digital condition under which we operate? The article begins with a reflection on the works of Wilhelm Dilthey and Michel de Certeau to discuss how the society in which the historian writes influences the practices of interpretation. The article then presents what can be understood as the digital condition of our present societies and shows how algorithms function as “black boxes” that influence our social interactions, communication, and understanding of the world. The article's third part brings together the earlier discussions of practices of history writing and the digital condition in order to examine the role of modeling for knowledge production in the sciences and the humanities. The closing argument then focuses on the use of visualizations in digital history as an example of the operational use of models of knowledge in opening the “black box” of interpretation.
Mediator role of intergroup anxiety in relationship between the social contact, intercultural sensitivity and attitudes towards Syrians among Turkish local society
Authors: Çalişkan Sari Arzu , Yalçinkaya Alkar Özden 
Published: December 2022

AbstractTurkey is the country with the highest Syrian refugee population hosted in the world. Social acceptance of immigrants by the local community is as important as the social cohesion of immigrants regarding the social integration process. The aim of the current study was to examine the role of social contact, intercultural sensitivity, intergroup anxiety, gender, age, education, abroad experience and city on attitudes of Turkish local society towards Syrians. In this regard, data were collected from 207 local community members living in Ankara and Adana provinces of Turkey. According to the analysis, qualitative social contact, intercultural sensitivity and intergroup anxiety predicted the attitudes of the local community towards Syrians. In addition, intergroup anxiety had a mediating role between qualitative social contact, intercultural sensitivity and attitudes towards Syrians. When close social contact and intercultural sensitivity of Turkish local society increase, intergroup anxiety decreases and it increases positive attitudes towards Syrians. Lastly, while there was no gender difference in attitude towards Syrians, females were higher in intercultural sensitivity than males.
Prospective prediction of developing internalizing disorders in ADHD
Authors: Karalunas Sarah L. , Antovich Dylan , Miller Natalie , Nigg Joel T. 
Published: December 2022

BackgroundClinical course in attention‐deficit/hyperactivity disorder (ADHD) is highly heterogeneous with respect to both core symptoms and associated features and impairment. Onset of comorbid anxiety and mood disorders during later childhood and adolescence is one critical aspect of divergent outcomes in ADHD. Characterizing heterogeneity in onset of anxiety and depression and identifying prospective predictors of these divergent courses may facilitate early identification of the children most at risk.MethodsA total of 849 children recruited for a case–control study of ADHD development, aged 7–12 years at baseline, completed up to six annual waves of comprehensive clinical and cognitive assessment, including multi‐informant behavior ratings, parent semi‐structured clinical diagnostic interviews, and measures of executive function (EF). Latent class growth curve analyses (LCGAs) characterized patterns of anxiety and depression over time. Trajectories were predicted from baseline parent‐rated child temperament, lab‐measured child EF, coded parental criticism, and child‐reported self‐blame for inter‐parental conflict.ResultsLatent class growth curve analyses separately identified three trajectories for anxiety and three for depression: persistently high, persistently low, and increasing. Temperamental fear/sadness and irritability were independent predictors that interacted with family characteristics. Baseline parental criticism and self‐blame for inter‐parental conflict exerted influence but only in the context of low temperamental risk. Better baseline child working memory was associated with delayed onset of depression.ConclusionsThe interaction of baseline child emotional features with EF or family environment predicted divergent courses of both anxiety and depression from middle‐childhood to mid‐adolescence. Results suggest modifiable risk factors associated with prospective differences in long‐term outcomes.