bluuebunny/crossref_metadata_2025_split huggingface dataset:
Searching for the Genus Epidemicus in Chinese Patients: Findings from the Clificol COVID-19 Clinical Case Registry
Authors: Tournier Alexander , Fok Yvonne , van Haselen Robbert , To Aaron 
Published: October 2022

Abstract
Background The Clificol COVID-19 Support Project is an innovative international data collection project aimed at tackling some of the core questions in homeopathy. This paper reports on the further investigation of the genus epidemicus concept during the first wave of the pandemic in the Chinese population.
Methods The design is an observational clinical case registry study of Chinese patients with confirmed or suspected coronavirus disease 2019 (COVID-19). The symptoms were prospectively collected via a 150-item questionnaire. The concept of genus epidemicus, including the role of treatment individualization, was investigated by analyzing whether presenting symptoms clustered into distinct groups. Two standard statistical analysis techniques were utilized: principal component analysis for extracting the most meaningful symptoms of the dataset; the k-means clustering algorithm for automatically assigning groups based on similarity between presenting symptoms.
Results 20 Chinese practitioners collected 359 cases in the first half of 2020 (766 consultations, 363 prescriptions). The cluster analysis found two to be the optimum number of clusters. These two symptomatic clusters had a high overlap with the two most commonly prescribed remedies in these sub-populations: in cluster 1 there were 297 prescriptions, 95.6% of which were Gelsemium sempervirens; in cluster 2 there were 61 prescriptions, 95.1% of which were Bryonia alba.
Conclusion This is the first study to investigate the notion of genus epidemicus by using modern statistical techniques. These analyses identified at least two distinct symptom pictures. The notion of a single COVID-19 genus epidemicus did not apply in the studied population.
A artroplastia total de joelhos bilateral simultânea pode ser segura
Authors: Gali Julio Cesar , Brotto Anna Flavia de Crescenzo , de Mello Danilo Pássaro Pires , Mauad Juliana Ribeiro , Gali Filho Julio Cesar 
Published: October 2022

Resumo
Objetivos Os objetivos deste estudo foram analisar a segurança da artroplastia total bilateral de joelho simultânea (ATJBS) e investigar a satisfação dos pacientes com o procedimento realizado de forma concomitante.
Métodos Em um estudo prospectivo, avaliamos 45 pacientes submetidos à ATJBS feita por duas equipes cirúrgicas. A idade média dos pacientes foi 66,9 anos, sendo 33 do gênero feminino (73,3%) e 12 (26,6%) do gênero masculino. No período intra- e pós-operatório foi seguido um protocolo de medidas visando a segurança do procedimento. Avaliamos o tempo de cirurgia, a perda sanguínea pelo hematócrito (Ht) e hemoglobina (Hb), obtidos no primeiro dia de pós-operatório, a porcentagem de pacientes que receberam transfusão de concentrado de hemácias e quantidade de unidades que foram necessárias. Verificamos as complicações no período perioperatório e, ao final de três meses, inquirimos aos pacientes sobre a preferência entre o procedimento simultâneo ou estagiado.
Resultados O tempo médio de cirurgia foi de 169 minutos; no pós-operatório houve um decréscimo médio de 28,2% do Ht e de 27,0% da Hb. Ao todo, 16 pacientes (35,5%) receberam transfusão de concentrado de hemácias (média de 1,75 unidades por paciente que precisou de reposição). Tivemos 12 complicações menores (26,6%) e 2 complicações maiores (4,4%); além disso, nenhum paciente teve o diagnóstico clínico de trombose venosa profunda e não houve mortes.
Conclusões A ATJBS pode ser considerada um procedimento seguro, se realizada em pacientes selecionados e com um protocolo de cuidados para prevenir complicações. Esse procedimento teve a aprovação unânime dos pacientes.
Oil and gas exploration and development in the Lake Eyre Basin: distribution and consequences for rivers and wetlands, including the Coongie Lakes Ramsar Site
Authors: Kingsford R. T. , Walburn A. J. D. 
Published: October 2022

Context Altered flooding regimes and pollution threaten the world’s wetlands, including floodplains of the largely free-flowing rivers. Aims We investigated the distribution of current and future oil and gas production and exploration on the floodplains of the Lake Eyre Basin. Methods We compiled these data and their associated infrastructure across the basin floodplains, including the Coongie Lakes Ramsar Site. Key results There were 831 oil and gas wells across the Lake Eyre Basin, predominantly (98.6%) on Cooper Creek floodplains, with 296 wells in the Coongie Lakes Ramsar Site, with 281 well pads, roads (870 km) and 440 storages. Only eight referrals occurred under the Environment Protection and Biodiversity Conservation Act 1999, despite potential Ramsar wetland impacts. Future oil and gas production licences, primarily unconventional gas production, covered ∼2.91 × 106 ha (Cooper Creek), 0.63 × 106 ha (Diamantina) and 1.03 × 106 ha (Georgina) of the floodplains. Conclusions and implications Oil and gas production and exploration disrupt flooding regimes, with pollution (spills and greenhouse gas emissions). Little rigorous environmental assessment existed to protect the Lake Eyre Basin rivers and Coongie Lakes Ramsar Site, despite state and Commonwealth legislation and policy for protection, which remain largely ineffective in controlling oil and gas development on this free-flowing river.
Escape from breast tumor dormancy: The convergence of obesity and menopause
Authors: Roy Roopali , Yang Jiang , Shimura Takaya , Merritt Lauren , Alluin Justine , Man Emily , Daisy Cassandra , Aldakhlallah Rama , Dillon Deborah , Pories Susan , Chodosh Lewis A. , Moses Marsha A. 
Published: October 2022

Obesity is associated with an increased risk of, and a poor prognosis for, postmenopausal (PM) breast cancer (BC). Our goal was to determine whether diet-induced obesity (DIO) promotes 1) shorter tumor latency, 2) an escape from tumor dormancy, and 3) an acceleration of tumor growth and to elucidate the underlying mechanism(s). We have developed in vitro assays and PM breast tumor models complemented by a noninvasive imaging system to detect vascular invasion of dormant tumors and have used them to determine whether obesity promotes the escape from breast tumor dormancy and tumor growth by facilitating the switch to the vascular phenotype (SVP) in PM BC. Obese mice had significantly higher tumor frequency, higher tumor volume, and lower overall survival compared with lean mice. We demonstrate that DIO exacerbates mammary gland hyperplasia and neoplasia, reduces tumor latency, and increases tumor frequency via an earlier acquisition of the SVP. DIO establishes a local and systemic proangiogenic and inflammatory environment via the up-regulation of lipocalin-2 (LCN2), vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) that may promote the escape from tumor dormancy and tumor progression. In addition, we show that targeting neovascularization via a multitargeted receptor tyrosine kinase inhibitor, sunitinib, can delay the acquisition of the SVP, thereby prolonging tumor latency, reducing tumor frequency, and increasing tumor-free survival, suggesting that targeting neovascularization may be a potential therapeutic strategy in obesity-associated PM BC progression. This study establishes the link between obesity and PM BC and, for the first time to our knowledge, bridges the dysfunctional neovascularization of obesity with the earliest stages of tumor development.
Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis
Authors: Rodriguez Diego A. , Quarato Giovanni , Liedmann Swantje , Tummers Bart , Zhang Ting , Guy Cliff , Crawford Jeremy Chase , Palacios Gustavo , Pelletier Stephane , Kalkavan Halime , Shaw Jeremy J. P. , Fitzgerald Patrick , Chen Mark J. , Balachandran Siddharth , Green Douglas R. 
Published: October 2022

The absence of Caspase-8 or its adapter, Fas-associated death domain (FADD), results in activation of receptor interacting protein kinase-3 (RIPK3)- and mixed-lineage kinase-like (MLKL)–dependent necroptosis in vivo. Here, we show that spontaneous activation of RIPK3, phosphorylation of MLKL, and necroptosis in Caspase-8– or FADD-deficient cells was dependent on the nucleic acid sensor, Z-DNA binding protein-1 (ZBP1). We genetically engineered a mouse model by a single insertion of FLAG tag onto the N terminus of endogenous MLKL (

Mlkl
FLAG/FLAG

), creating an inactive form of MLKL that permits monitoring of phosphorylated MLKL without activating necroptotic cell death.

Casp8
−/−
Mlkl
FLAG/FLAG

mice were viable and displayed phosphorylated MLKL in a variety of tissues, together with dramatically increased expression of ZBP1 compared to

Casp8
+/+

mice. Studies in vitro revealed an increased expression of ZBP1 in cells lacking FADD or Caspase-8, which was suppressed by reconstitution of Caspase-8 or FADD. Ablation of ZBP1 in

Casp8
−/−
Mlkl
FLAG/FLAG

mice suppressed spontaneous MLKL phosphorylation in vivo. ZBP1 expression and downstream activation of RIPK3 and MLKL in cells lacking Caspase-8 or FADD relied on a positive feedback mechanism requiring the nucleic acid sensors cyclic GMP-AMP synthase (cGAS), stimulator of interferon genes (STING), and TBK1 signaling pathways. Our study identifies a molecular mechanism whereby Caspase-8 and FADD suppress spontaneous necroptotic cell death.
Visualizing language learning environments beyond the classroom in study abroad
Authors: Kashiwa Mayumi 
Published: October 2022

Abstract
Employing an ecological framework, this study explores learners’ visual representation of their language learning
practices and environments beyond the classroom in an Australian context. Specifically, this study’s aim is to better understand
the features of individual language learning environments, the role of self-reflection, and the affordances involved in the
construction of these environments. One hundred and seventy international students enrolled in English Language Intensive Courses for Overseas
Students (ELICOS) in Sydney drew mind maps on “Activities to improve my English in Australia.” The mind maps were analyzed
thematically using NVivo 11 software and subsequent themes were developed. Findings showed individual differences in features of
language learning environments, learners’ perceptions of their affordances, and insight into the degree of learner agency as seen
from the visualization. This article closes by discussing the implications for using such visual materials in second language pedagogy in order
to understand student language learning beyond the classroom.
Large gauge transformations, local coordinates and cosmological observables
Authors: Mitsou Ermis , Yoo Jaiyul 
Published: October 2022

Abstract
In recent years new types of coordinate transformations have appeared in cosmology on top of the standard gauge transformations, such as the dilatations and special conformal transformations, or the ones leading to (conformal) Fermi coordinates. Some of these can remove effects that are invariant under the standard gauge transformations and also affect asymptotic boundary conditions, thus introducing a non-trivial ambiguity in our cosmological modeling. In this short note we point out that this ambiguity is irrelevant for the quantities we use to compare our model with observations—the cosmological observable relations—as they are invariant under all of these transformations. Importantly, this invariance holds only if one takes into account all the relativistic contributions to an observable, which is not the case in the literature in general. We finally also show that the practically-relevant property of conformal Fermi coordinates (a Friedmann-Lemaître-Robertson-Walker (FLRW) metric up to second order in distance) can be achieved through a globally-defined standard gauge transformation.
Pure shape dynamics: general framework
Authors: Koslowski Tim , Naranjo Pedro , Vassallo Antonio 
Published: October 2022

Abstract
We put forward a general framework for describing relational physical theories, which we call pure shape dynamics (PSD). Elaborating on the original insights brought about by the shape dynamics programme, PSD’s novel take on relationalism is its insistence on describing any dynamical system by means of the intrinsic geometry of its associated curve in the suitable relational configuration space of the theory, namely shape space, whereby the corresponding equation of state of the curve expresses the ratio of change of one of its geometric degrees of freedom with respect to another one. The mathematical structure underlying the equation of state is a local section over a natural generalisation of the unit tangent bundle, which we call shape phase space.
Linear dependence of dislocation pattern size on the imprint width and scratch width on (0001) GaN
Authors: Ishikawa Yukari , Sugawara Yoshihiro , Yao Yongzhao , Takeda Hidetoshi , Aida Hideo , Tadatomo Kazuyuki 
Published: October 2022

Abstract
With the aim of developing a method of estimating the thickness of an affected layer on a wide-bandgap semiconductor wafer caused by scratching, we investigated the dependence of dislocation pattern size on the width of the imprint (or scratch) induced by the Berkovich indentation (or scratching) using a Berkovich indenter. We found that the penetration depth and width of the dislocation pattern induced on (0001) GaN by indentation are approx. 0.9 times and 30 times that of the imprint width and the imprint depth, respectively. Based on the linearity between the imprint width and the square root of load (SqL), the constant hardness is confirmed to be 0.1 mN or more. In comparison to laterally expanding dislocation generation, inclined dislocation generation has a lower threshold load. The cause of this threshold discrepancy is discussed based on the imperfection of the indenter tip. The scratch width linearly increased with the SqL in the range of 0.5–7 mN. The width and depth of the dislocation pattern induced by the scratch are approx. 11–13 and 0.75–1 times the scratch width, respectively. The width of the dislocation pattern of the [1

1
ˉ

00] scratch is larger than that of the [11

2
ˉ

0] scratch, however, the penetration depth of the dislocation pattern of [1

1
ˉ

00] is smaller than that of [11

2
ˉ

0]. These findings indicate that estimating the affected layer thickness induced by mechanical polishing or grinding is possible only by finding the widest scratch on a wafer.
High-performance bifunctional oxygen electrocatalysts for zinc-air batteries over nitrogen-doped carbon encapsulating CoNi nanoparticles
Authors: Liu Hengqi , Hua Daxing , Wang Ran , Liu Zhiguo , Li Jiajie , Wang Xianjie , Song Bo 
Published: October 2022

Abstract
The nitrogen doped carbon (NC) encapsulating metal particles (metal/NC) are promising low-cost bifunctional oxygen electrocatalysts for rechargeable Zn-air batteries. However, the states of the art catalytic performance are still significantly restricted by the limited content of active sites for oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). Herein, a series of NC encapsulating CoNi samples as a bifunctional catalyst for both ORR and OER were synthesized via a simple pyrolysis method. Large surface area and high content M–N
x
active sites promote the ORR activity and accelerate the surface reconstruction layer for high OER performance. The NC encapsulating CoNi with optimized Co/Ni ratio (2:1) shows high ORR activity with a half-wave of potential (0.85 V) and a low overpotential of 309 mV for OER. Rechargeable Zn-air battery assembled by an air cathode with the NC encapsulating CoNi exhibits a power density of 143 mW cm−2 and good cyclability over 100 h at 10 mA cm−2. This mechanism work provides a feasible strategy for developing high activity and low cost bifunctional oxygen electrocatalysts.
Absolute distance measurements for in-situ interferometer characterisation using range-resolved interferometry
Authors: Shmagun Vitalii , Gerhardt Uwe , Fröhlich Thomas , Manske Eberhard , Kissinger Thomas 
Published: October 2022

Abstract
Range-resolved interferometry (RRI) allows the simultaneous demodulation of multiple interferometric signal sources and provides a tomographic view of all constituent interferometers that may be present in a setup. Through comparison with a reference distance of known length, absolute distance measurements can be performed. RRI is tailored to the use of laser frequency modulation through injection-current modulation of regular, monolithic laser diodes that are both cost-effective and highly coherent and therefore this approach promises broad applicability. In this paper, two methods for absolute distance measurement, one based on the direct evaluation of the signal peak positions and one based on the phase demodulation of an additional lock-in modulation signal, are experimentally demonstrated. Using an external verification displacement interferometer, both techniques are shown to achieve in-situ absolute distance measurements with systematic errors below

±
0.1
%

over a 50 mm travel range. The aim of this paper is to establish the general suitability of RRI for absolute distance measurements and in-situ tomographic interferometer characterisation for precision engineering. In future, this approach could be used to diagnose interferometric setups for parasitic signal contributions, multiple reflections or to determine the dead path length for accurate environmental compensation, either for use during initial setup of, or for continuous operation alongside, a regular displacement measuring interferometer.
Correlation-based algorithms for accurate PIV measurement near the slip boundary
Authors: Cao Yufan , Wang Xiangyu , Yuan Huijing , Duan Huiling , Sun Zhili , Li Hongyuan , Lv Pengyu 
Published: October 2022

Abstract
Accurate particle image velocimetry (PIV) measurement near the wall is of great significance in many fields. However, it is challenging for conventional PIV algorithms to deal with the near-wall flow, especially under the slip boundary condition. In general, the conventional window correlation method cannot accurately calculate the flow velocity at any location that is less than half the size of the interrogation window away from the boundary. For steady or periodic flow, the single-pixel ensemble correlation method can estimate the velocity very near the wall, but numerous image pairs are required, which comes at a great computational cost. In this paper, a new method based on window deformation is proposed to estimate the velocity profile of near-wall flows. Furthermore, a multi-pixel ensemble correlation method is proposed based on the single-pixel method, which improves accuracy and significantly reduces the computational cost relative to the single-pixel method. Both methods are validated by synthetic particle images and experiments. The present work extends the PIV methodology for accurately measuring near-wall flows, especially under the slip boundary condition, which will benefit research on the boundary layer, drag reduction, microfluidics, etc.
Ambipolar steep-slope nanotransistors with Janus MoSSe/graphene heterostructures
Authors: Zhang Xinjiang , Huang Anping , Xiao Zhisong , Wang Mei , Zhang Jing , Chu Paul K. 
Published: October 2022

Abstract
The transfer characteristics and switching mechanism of the steep-slope transistor composed of the graphene/Janus MoSSe heterostructure are investigated by quantum transport calculation. The Schottky barrier height at the Gr/SMoSe interface and tunneling width between the channel and drain can be tuned by the gate voltage, so that the device exhibits ambipolar switching with two minima in the subthreshold swing slope. 34 and 29 mV decade−1 subthreshold swings can be achieved and the on/off ratios are over 106 and 108 for the different switching mechanisms. The device provides a solution and guidance for the future design of low-power, high-performance devices.
Spray coated micropatterning of metal halide perovskite for anticounterfeiting fluorescent tags
Authors: Hossain Modasser , Santra Pralay K 
Published: October 2022

Abstract
Metal halide perovskites possess exciting optoelectronic properties and are being used for various applications, including fluorescent anticounterfeiting security tags. The existing anticounterfeitings based on perovskites have a reversible transition that does not allow to know whether the information is tampered or compromised. In this work, we developed fluorescent anticounterfeiting security tags using micropatterned metal halide perovskite nanocrystals. The micro features were created by spray coating of stabilized methylammonium lead tribromide (MAPbBr3) nanocrystals (NCs) in polystyrene (PS) solution, which has a proper wettability to various rigid and flexible substrates. The PS provides additional optical and structural stability to the MAPbBr3 NCs against polar solvents. By combining stable and unstable MAPbBr3 nanocrystals, we created a double-layer fluorescent anticounterfeiting security tag, and the information is hidden under both ambient light and UV illumination. An irreversible decryption is possible after treating the security tags with particular solvents, thus tampering of the security tag is easily detectable.
Microelectronic current-sourcing device based on band-to-band tunneling current
Authors: Sul Onejae , Lee Yeonghun , Kim Sangduk , Kwon Minjin , Sun Hyeonjeong , Bang Jiyoung , Ju Hyungbeen , Choi Eunsuk , Lee Seung-Beck 
Published: October 2022

Abstract
A new stable current-sourcing transistor is developed using the band-to-band tunneling phenomenon. A heterojunction between thin film WS2 and heavily hole-doped bulk silicon converts a section of the WS2 contacting the silicon into a hole-doped WS2 inside the WS2 channel, and band-to-band tunneling occurs between the electron-doped and hole-doped WS2. The output current is regulated by the tunneling barrier thickness. The thickness depends on the gate bias for device switching, but is less sensitive to the source bias, enabling stable output currents. The minimum line sensitivity is 2.6%, and the temperature coefficient is 1.4 × 103 ppm °C−1. The device can be operated as a current sourcing device with an ultralow output current and power consumption.
Effect of sodium thiazolinyl dithiopropane sulphonate (SH110) addition on electroplating nanotwinned copper films and their filling performance of fine-pitch redistributed layer (RDL)
Authors: Huang Jing , Gao Li-Yin , Peng Zhen-Jia , Li Zhe , Liu Zhi-Quan , Sun Rong 
Published: October 2022

AbstractNanotwinned copper is a potential microelectronic interconnection material due to its superior strength and conductivity, however, its filling ability is urgently needed to improve before its application in the field of advanced packaging. The effect of additive (sodium thiazolinyl dithiopropane sulphonate, SH110) addition on the surface roughness, microstructure, mechanical properties and filling capacity of nanotwinned copper films was investigated. The surface roughness and grain size were firstly reduced then increased with the increasing concentrations of SH110, reaching the minimum value at 10 ppm. It was noticed that copper films with 10 ppm SH110 also possessed superior tensile strength and elongation, which were measured as 481 MPa and 3.68% on average of 12μm thick samples by dynamic thermo-mechanical analyzer. Further, their uniformity and flatness of redistributed layers (RDLs) were controlled as 2% and 1.9%, which were significantly improved compared to the samples without SH110 (7.6% and 4.7%). As demonstrated by linear sweep voltammetry analysis and galvanostatic measurement, the SH110 could cooperate well with gelatin and serve as a combination of accelerator and leveler, resulting in the improvement of filling capacity for nanotwinned copper RDLs.