bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual Bioactivity of Angiotensin Converting Enzyme Inhibition and Antioxidant Novel Tripeptides from Sipunculus nudus L and Their Related Mechanism Analysis for Antihypertention
Authors: Liu Huan , Cai xiaoxuan , Huang Miaoen , Wang Tianji , Li Li , Luo Hui , Lu Yingnian 
Published: September 2022

Abstract
The pathogenesis of hypertension is related to many factors including active ACE and excess ROS, the combination of ACE inhibition and antioxidant activity in one compound might be useful for the treatment of hypertension. Sipunculus nudus L contain high protein content, which can be used as a valuable raw material to prepare bio-active peptides. In this study, two novel tripeptides, LPK and PRP, with dual bioactivity of ACE inhibition and antioxidant were purified and identified from Sipunculus nudus L. The antioxidant activities of LPK and PRP are dose-dependent, including DPPH, superoxide anion and hydroxyl radical scavenging activities. Moreover, the antioxidant activity of PRP was stronger than that of LPK. In addition, LPK and PRP also show higher ACE inhibitory activity, with IC50 of 6.54 mM and 0.42 mM, respectively. Molecular docking simulation showed that both the peptides could interact with the active ACE sites via hydrogen bonds, which can reduce the production of Ang II, thereby; LPK and PRP treatment could decrease Ang II-triggered superoxide production, and meanwhile, the peptides treatment could directly remove excess reactive oxygen species. The above-mentioned advantageous effects appeared to involve the stress of the RAS and scavenging ROS, both were benefit to treat hypertension. This research showed that LPK and PRP had potential to be developed as antihypertension agents, which might be a new strategy for high value utilization of Sipunculus nudus L as functional food material.
Disrupted cellulose aggregation leads to the reduced mechanical performance of wood-adhesive interphase during freeze-thaw cycles
Authors: Cao Yizhong , Xu Chuhang , Xu Shuwei , Chen Haili , Yan Yutao , Chen Yifan , Wu Qiang , Wang Siqun 
Published: September 2022

Abstract
The mechanical performance of wooden engineered composites facing the freeze-thaw cycles (FTCs) arises as an attention-worthy issue since the application of timber architectures in cold climates spreads. Here, we reported an investigation to reveal the losses of the mechanical performance of the wood-phenol formaldehyde (PF) adhesive interphase after the FTCs. Results revealed that PF adhesive was barely affected by the FTCs due to the low moisture content and rigid networks, whereas the mechanical properties of the cell wall in wood-PF interphase reduced significantly (more than 30%) after 5 FTCs at -40℃. Cracks were observed in the cell wall and compound middle lamella after FTCs. Further investigation into the crystal structure of the cell wall in the wood-PF interphase demonstrated that the FTCs disrupt the aggregations of cellulose macromolecules. The stresses caused by the phase transition of free water and the external hydrogen bonds formed between water and cellulose disrupted hydrogen bond networks in the cell wall. A plausible mechanism for the FTCs reducing the mechanical properties of the wood-PF bonds can be concluded as the cracks and weakened cell walls crippled the structural integrity of the wood-PF interphase, making it a fragile and stress-concentrated site when subjected to load.
Shedding light on static and dynamic hyperpolarizabilities of thia[7&amp;8]circulenes, toward their NLO applications
Authors: Kosar Naveen , Ayub Khurshid , Gilani Mazhar Amjad , Arshad Muhammad , Mahmood Tariq , Kosar N. K 
Published: September 2022

Abstract
Herein, we examined optoelectronic properties of thia[7&8]circulenes (1-18). Although Circulenes are the elemental building blocks of well-known nanomaterials such as graphene, nanotubes, and fullerenes. Organic chemists have given attention to circulenes during their studies for the improvement and development of aromaticity concept, but NLO properties of these structure-forming circulene subunits are not properly studied. The considered compounds (1-18) are thermodynamically, kinetically and chemically stable. Nonlinear optical (NLO) response is evaluated through static and frequency dependent first and second hyperpolarizabilities analyses. The static first hyperpolarizability (βo) of these compounds ranges between 0.00 – 496.54 au. The frequency dependent coefficients for all thia[7 & 8]circulenes show remarkable enhancement at 532 and 1064 nm, respectively. The nonlinear refractive index is increased up to 1.13×10−14 au for circulene 9 among all thia[7 & 8]circulenes at 532 nm. These findings successfully demonstrated that thia[7&8]circulenes nonlinear optical response can be increased by decorating multiple sulfur atoms. The unsymmetrical distribution of sulfur atoms is more effective as compared to symmetrical distribution.
Comparative effect of inflation versus practice changes on the payments for care: an example from stroke
Authors: Morrow Corey M. , Simpson Annie N. , Almallouhi Eyad , Woodbury Michelle L. , Simpson Kit N. 
Published: September 2022

Abstract
Background: Adjusting for inflation for longitudinal economics analyses is essential to account for changes in monetary valuation. Inflation calculators are common as they provide fast results with minimal resource expenditure. However, their sensitivity to new, high-cost interventions is unknown.Methods: We analyzed hospital payments for acute ischemic stroke survivors from the 2018 5% Medicare Limited Data Sets from the Centers for Medicare and Medicaid Services (CMS). Patients were stratified by severity using the Stroke Administrative Severity Index (SASI) score, which is a validated measure used to describe stroke severity at hospital discharge. Next, we inflated previously published 2014 payments using the US Consumer Price Index: Medical Care (CPI) rates from 2014 to 2018. Results: The inflated 2014 hospital care payments for Mild stroke survivors increased from $6,850 to $7,593, Moderate from $8,456 to $9,373 and Severe from $9,688 to $10,739. After comparing CPI inflated estimates from 2014 to 2018 we found that Mild and Moderate SASI levels were slightly less costly in the true 2018 payments than the inflated 2014 payments, while Severe SASI patients were $2,117 more costly than the 2014 adjusted costs. Our results indicate noteworthy differences in actual versus inflation-adjusted payments particularly for Severe stroke survivors. This is likely due to the emergence and integration of high-cost endovascular thrombectomies (eVT) into standard practice. Conclusions: Though inflation calculators are less resource intensive than cost analyses, they do not necessarily capture true cost changes for stroke survivors. This is one of many reasons that health economists should collaborate with clinicians to discuss clinical factors that may significantly influence longitudinal cost comparisons.
Pediatric Germ Cell Tumors- Pathological Variations and Challenges
Authors: Talat Nabila , Khalid Rija , Tahir Warda , Mirza Muhammad Bilal , Sattar Farrukh Mahmood , Mahmood Adnan , Nayyer Sajid Iqbal , Azam Kamran 
Published: September 2022

Abstract
Aims:Germ cell tumors (GCT) are uncommon in children and adolescent but when they appear, gonads are the most frequent site. Testicular tumors constitute 1-2% of all pediatric solid tumors among them 84% are GCT. Incidence of ovarian GCT is 67%. This study from a single center focus on highlighting clinical features, investigations, treatment and outcome of GCTs in children to look for peri operative challenges and long term prognosis.MethodsA prospective study of 45 patients with GCTs was done from March 2018 to January 2022. The detailed data of each patient was scrutinized including history, physical examination, investigations, management, and follow-up. Forty-five patients presented during this period. Fifteen male (33.3%) and 30(66.7%) female with median age of 4.8 years. Twenty-eight( 62.2%) patients presented with abdominal mass, 15(34.88%) with scrotal swelling and 2(4.65%) with acute abdomen. Hematological and radiological investigations were done in all patients. α-fetoprotein level was high in 30 patients. All patients were managed combinedly with Paediatric Oncology. After being discussed in multidisciplinary tumor board, surgical excision was done.Results:On gross, 75% were mixed and 25% were solid tumors. Median size of testicular tumors ranged from 3cm to 8cm while ovarian tumors ranged from 5cm to 23cm. on histology, Twenty six(57.8%) were mature teratoma, 6 (15.5%) immature teratoma, 8(17.7%) yolk sac tumors, while 1(2.32%) mixed stromal tumor, 1 (2.32%) sex cord tumor and 1(2.2%) Leydig cell tumor also reported. Neo-adjuvant chemo was given in 4 (8.88%) patients while 6 (13.33%) patients received chemotherapy postoperatively. Rest of the patients didnot receive chemotherapy as they had stage I & II disease. Thirty-three patients are doing fine, 11 had lost follow up and 1 patient expired due to sepsis. Long term follow-up with tumor markers and radiological investigations showed no recurrence in majority of patients (73%).ConclusionGCTs in Pediatric population are not uncommon. However good prognosis can be expected if diagnosed at early stage. Majority of tumors doesn’t require post-operative chemotherapy. Tumor markers especially alpha-fetoprotein seems reasonable prognostic marker on follow up in centers where other genetic studies aren’t available due to limited resources.
Assessment of the impacts of ground fissuring in the Main Ethiopian Rift: the case of the rift margin areas of Siltie Zone, southern Ethiopia, East Africa
Authors: Ridwan Munir 
Published: September 2022

Abstract
This paper presents the impact assessment of ground fissuring in rift margin districts of Siltie Zone in southern Ethiopia, which is located at the western margin of the central portion of the Main Ethiopian Rift. Field investigations, literature reviews and interviews were employed in the study. Faults are the major structural units in the area shaping the landscapes as well as determining the size and positions of recent alluvial deposits. The geology of the area is made of rhyolitic ignimbrites at the bottom followed by basalts, and scoria cones are also common. Overlying this stratigraphy are thick unconsolidated alluvial deposits, at places reaching up to 70m and filling grabens created by the regional faulting. Almost all the settlements and agricultural practices are concentrated on this fertile recent sediment. The area is frequently affected by ground fissuring that mainly occur as vertical cracks and ranges from discontinuous hairline fractures to open ground cracks up to 1200m long, as much as 0.5m to 6m wide, and up to 5.2m deep. The fissures are aligned in NNE-SSW directions, the average strike being N16oE. Manmade structures such as homes, water pipelines and storage tankers are destroyed by the fissuring. Agricultural lands and trees are also severely damaged. This heavily affected the food security in the districts since most of the residents are farmers. Some extensions of the fissures however are not exposed to the surface rather formed underground caves and sinkholes and will be future dangers in the area and need proper buffering.
Effects of fetal famine exposure on the cardiovascular disease risk in the metabolic syndrome individuals
Authors: shu zhe , Ding Xiong , Qing Yue , Ma XiaoXu , Liu MinHong , Wu YunTao , Yang Peng , Wu Ying , Li Yun , Wu Shouling 
Published: September 2022

Abstract
Background
Patients with metabolic syndrome (MS) have a higher incidence of cardiovascular disease (CVD), but the possible mechanisms are not fully understood and further exploration of the possible factors influencing the high incidence of CVD in patients with MS is still needed.
Objectives
This study aims to examine the association between fetal famine exposure and the risk of CVD in adulthood in people with MS.
Methods
The 13,744 MS patients free of CVD selected from the Kailuan cohort in 2006 (referred as the baseline survey) were included in the study. All patients were born between January 1, 1949, and December 31, 1974. Based on the date of birth, all patients were divided into the no-exposed group (born between January 1, 1963, and December 31, 1974), uterine famine exposed group (born between January 1, 1959 and December 31, 1962), and childhood famine exposed group (born between January 1, 1949 and December 31, 1958). After following up to December 31, 2019, the weighted Cox regression analysis model was used to calculate the effect of early life famine exposure in MS individuals on the risk of CVD in adulthood.
Results
During the 12.12 years of follow-up, the incidence of CVD was 5.87%, 10.13%, and 10.90% in the no-exposed group, uterine famine exposed group, and childhood famine exposed group, respectively. Compared with participants in the no-exposed group, the CVD risk and stroke risk increased in participants in the uterine famine exposed group (for CVD, HR: 1.32,95% CI:1.04–1.67; for stroke, HR:1.37,95% CI: 1.05–1.79), but not in childhood famine exposed group. However, the increased CVD risks were only observed in females or smokers. No increased MI risks were observed for participants in the uterine famine exposed group or childhood famine exposed group.
Conclusions
Our findings suggested that exposure to famine during fetal life significantly increased the risk of developing CVD in adulthood in individuals with MS, and this association was enhanced in females or smokers.
Blast performance prediction of circular column with improvised equivalent helical mesh transverse reinforcement substituted for single helix, UHPFRC plaster and CFRP wrapping under close-in blast
Authors: Tahzeeb Rafat , Alam Mehtab , Muddassir S.M. 
Published: September 2022

Abstract
The explosion from bombshells develops an excessively high impulsive load on structures. Columns being important key load-bearing members of a structure are vital to providing strength and stability to the building. A circular column performs better than a square/rectangular column under blast loading. Following the validation of experimentally tested square RC column with seismic lateral reinforcement carrying 950kN axial load subjected to an explosive charge of 100kg ANFO (82kg-TNT equivalent) at a scaled distance of 1.00m/kg1/3 with 10mm mesh size using ABAQUS/EXPLICIT software equipped with concrete damage plasticity (CDP) model, an equivalent circular reinforced concrete (RC) column is considered. It is well known that the performance of the circular RC column with single helical transverse reinforcement is superior compared to circular lateral ties. To improve the blast-impact resistance of circular column provision for helical reinforcement mesh using six bars turning successive bars in opposite direction is attempted in this work. The performance of a column with equivalent helical mesh is compared with the column with single helical transverse reinforcement. Further, UHPFRC plaster, as well as CFRP wrapping, are considered on the two columns under the close-in blast loading. The thickness of UHPFRC plaster and CFRP wrapping considered in this study are 15mm and 2mm respectively. The effect of plaster and wrapping on the two columns in terms of confinement of concrete and stresses in longitudinal steel are investigated and compared. Maximum deflection and damage of the columns are predicted.
Importing experimental results via S2D model in ADS tool for Power Amplifier Design
Authors: Bhargava Gaurav , Majumdar Shubhankar , Medjdoub Farid 
Published: September 2022

Abstract
In this paper, behavioral modelling of a power amplifier is implemented by using S2P and S2D model setup. By using the standard power amplifier for obtaining the measured results of Scattering (S-parameters and large signal parameters. These parameters are imported into the S2P and S2D model to perform the small signal and large signal analysis at 3 GHz frequency. Then, the simulated results are compared with the measured results to verify the efficient utilization of behavioral models. The novelty of this work deals with the simulation study of the characteristics of a silicon-based driver amplifier which are obtained directly from the measurements. This work can be utilized to determine the influence of the driver amplifier properties on the power amplifier measurements via simulation. At last, the study of relative error performance analysis between measured and simulated results of different parameters is carried out and calculated of NMSE (in %) for S11, S12, S21, S22, gain, pout, 1 dB compression point, ACP, 3rd harmonics, 4th harmonics, and 5th harmonics are 0.0083, 0.0055, 0.0086, 0.011, 0.0844, 0.814, 0.926, 0.71, 0.22, 0.012 and 0.070 respectively.
Organizational factors associated with delayed therapeutic hypothermia in neonatal hypoxic-ischemic encephalopathy: the LyTONEPAL cohort
Authors: Beck Jonathan , Debillon Thierry , Guellec Isabelle , Vilotitch Antoine , Loron Gauthier , Bednarek Nathalie , Ancel Pierre-Yves , Pierrat Véronique , Ego Anne 
Published: September 2022

Abstract
Initiation of therapeutic hypothermia (TH) within 6 hr of life is a major concern for treating neonatal hypoxic ischemic encephalopathy (HIE). We aimed to determine clinical and organizational factors associated with delayed TH in a French population-based cohort of neonates with moderate or severe HIE. Time to reach a rectal temperature of 34°C defines optimal and delayed (within and > 6 hr) TH. Clinical and organizational factors associated with delayed TH were analysed among neonates born in cooling centres (CCs) and non-cooling centres (non-CCs). Among 629 neonates eligible for TH, 574 received treatment (91.3%). TH was delayed in 29.8% neonates and in 20.3% and 36.2% of those born in CCs and non-CCs, respectively. Neonates with moderate HIE were more exposed to delayed TH in both CCs and non-CCs. After adjustment for HIE severity, maternal and neonatal characteristics and circumstances of birth were not associated with increased risk of delayed TH. However, this risk was 2 to 5 times higher in maternities with < 1999 annual births, when the delay between birth and call for transfer (adjusted odds ratio [aOR] 2.47, 95% confidence interval [CI] [1.03 to 5.96]) or between call for transfer and admission (aOR 6.06, 95%CI [2.60 to 14.12]) was > 3 hr and when an undesirable event occurred during transfer (aOR 2.66, 95%CI [1.11 to 6.37].
Conclusion: Increasing early identification of neonates who could benefit from TH together with access to TH in non-CCs before transfer are modifiable factors that could improve the care of neonates with HIE.
Immune-related interstitial lung disease adverse event following immune checkpoint inhibitors and immune checkpoint inhibitors plus anti-VEGF antibody/chemotherapy: A real-world study from 2014 to 2022 based on FAERS databases
Authors: Cui Chanjuan , Ren Xiayang , Cui Wei , Wang Yanfeng 
Published: September 2022

Abstract
Purpose
This study further approaches immune-related interstitial lung disease adverse event (AE) in patients undergoing immune checkpoint inhibitor (ICI) monotherapy, ICI plus chemotherapy and ICI plus anti-VEGF therapy in the postmarketing period.
Methods
This study analysed reports for ICI-related interstitial lung disease AE from the FDA Adverse Event Reporting System (FAERS) database between 2014 and 2022. The reporting odds ratio (ROR) and Bayesian confidence propagation neural networks of information components (IC) were computed to identify disproportionate reporting of ICI-related interstitial lung disease.
Results
44,964,609 records were extracted from the FAERS database, with 9150 records for interstitial lung disease after ICI treatment. Men had a slightly higher reporting frequency than women (63.07% vs. 25.69%). The morbidity rate (2.05%) of acute respiratory distress syndrome was low, the fatality rate (67.55%) was the highest, the time to onset was relatively short. Within 3 months, the cumulative proportion of ICI-related interstitial lung disease records was 75.03%. The ICI plus anti-VEGF therapy group had the lowest frequency of interstitial lung disease AEs compared to the ICI monotherapy group and the ICI plus chemotherapy group (IC025 = 1.72, IC025 = 3.21, IC025 = 3.22). Moreover, ICI plus anti-VEGF therapy group had the narrowest spectrum of interstitial lung disease among these three therapeutic regimens.
Conclusion
This study showed a high reporting frequency and substantial characteristics of a spectrum of interstitial lung disease AEs after different ICI regimens. Notably, ICI plus anti-VEGF therapy might be a treatment method that can to some extent control ICI-related interstitial lung disease. These data provide some important information for clinicians to weigh the risks and benefits of different ICI regimens.
Characteristics of Appendicitis after Immune Checkpoint Inhibitor Therapy among Cancer Patients
Authors: Mathew Antony , Shatila Malek , Lai Zongshan , Tan Dongfeng , Oliva Isabella C. Glitza , Wang Jianbo , Alhalabi Omar , Zhang Hao Chi , Thomas Anusha , Wang Yinghong 
Published: September 2022

Abstract
PurposeImmune checkpoint inhibitor (ICI) therapy has revolutionized cancer care but is associated with immune-related adverse events (irAEs). Recent case reports raised the concern that acute appendicitis may be an irAE. In this study, we sought to describe the disease course of post-ICI therapy appendicitis and its associated complications.Methods Adult patients who had an International Classification of Diseases code for appendicitis within the first 2 years after initiating ICI therapy from January 2010 to April 2021 and who had imaging evidence of appendicitis were studied retrospectively. Results 13,991 patients were identified who had ICI exposure during the study period, 44 had codes for appendicitis, 10 of whom met the inclusion criteria. Their median age at the time of diagnosis was 59 years. The median time from ICI therapy initiation to appendicitis onset was 188 days. The most common presenting symptoms were abdominal pain (70%) and fever (40%). Abscesses were present in two patients, and a perforation was present in one. All 10 patients received broad-spectrum antibiotics. Five patients needed surgery or interventional radiology drainage. Nine patients had resolution of appendicitis symptoms after treatment. ConclusionPost-ICI therapy appendicitis is rare but presents similarly to and has similar complications rates as conventional appendicitis. Appendectomy remains the mainstay of treatment, but its use can be limited in cancer patients. The decision to continue ICI therapy remains at the discretion of the clinician. Further studies are needed to bring awareness to and advance the understanding of this clinical entity.