bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myocardial CT perfusion imaging for the detection of obstructive coronary artery disease: multisegment reconstruction does not improve diagnostic performance
Authors: Preuß Daniel , Garcia Gonzalo , Laule Michael , Dewey Marc , Rief Matthias 
Published: January 2022

AbstractBackgroundMultisegment reconstruction (MSR) was introduced to shorten the temporal reconstruction window of computed tomography (CT) and thereby reduce motion artefacts. We investigated whether MSR of myocardial CT perfusion (CTP) can improve diagnostic performance in detecting obstructive coronary artery disease (CAD) compared with halfscan reconstruction (HSR).MethodsA total of 134 patients (median age 65.7 years) with clinical indication for invasive coronary angiography and without cardiac surgery prospectively underwent static CTP. In 93 patients with multisegment acquisition, we retrospectively performed both MSR and HSR and searched both reconstructions for perfusion defects. Subgroups with known (n= 68) or suspected CAD (n= 25) and high heart rate (n= 30) were analysed. The area under the curve (AUC) was compared applying DeLong approach using ≥ 50% stenosis on invasive coronary angiography as reference standard.ResultsPer-patient analysis revealed the overall AUC of MSR (0.65 [95% confidence interval 0.53, 0.78]) to be inferior to that of HSR (0.79 [0.69, 0.88];p= 0.011). AUCs of MSR and HSR were similar in all subgroups analysed (known CAD 0.62 [0.45, 0.79]versus0.72 [0.57, 0.86];p= 0.157; suspected CAD 0.80 [0.63, 0.97]versus0.89 [0.77, 1.00];p= 0.243; high heart rate 0.46 [0.19, 0.73]versus0.55 [0.33, 0.77];p= 0.389). Median stress radiation dose was higher for MSR than for HSR (6.67 mSvversus3.64 mSv,p< 0.001).ConclusionsMSR did not improve diagnostic performance of myocardial CTP imaging while increasing radiation dose compared with HSR.Trial registrationCORE320:clinicaltrials.govNCT00934037, CARS-320: NCT00967876.
Mobile phone radiation might alter gene expression in the oral squamous epithelial cells
Authors: Khalil Ahmad M. , Al-Qaoud Khaled M. , Alemam Israa F. , Okour Mohammad A. 
Published: January 2022

Abstract
Background
Accumulating evidence has shown that radiofrequency radiation (RFR) emitted by mobile phones is a potential factor for DNA damage. Whether RFR affects the gene expression of human genes still requires further research. This may help in understanding the mechanisms of action of this radiation. On the assumption that expression of BAMBI and Survivin in the oral squamous epithelial cells might be modified in response to RF electromagnetic field (RF-EMF) exposure, the current study was conducted on a group of young university student volunteers.

Results
Statistical analysis of the RT-PCR data indicated that no significant association (P value ˃ 0.05) exists between the expression of either gene, and neither the length of history nor the frequency of the phone use.

Conclusions
Although no clear RF-EMF signature on gene expression could be detected in this in this preliminary study, it is one of the few studies indicating that molecular-level changes might take place in humans in response to chronic mobile phone EMR exposure. Further investigations in this field are warranted.
Efficacy and safety of sofosbuvir and daclatasvir in patients with chronic hepatitis C virus induced cirrhosis with Child-Pugh class B
Authors: El Raziky Mayssa , Hamdy Sherif , Hamada Yasser , Abdelaziz Nermin Mohamed , Hassany Mohamed , Doss Wahid , Zakaria Zeinab 
Published: January 2022

Abstract
Background
This study aimed to evaluate the efficacy, safety and tolerability of SOF/DCV ± RBV in a cohort of Egyptian patients with chronic hepatitis C (CHC)-induced cirrhosis with decompensation (class B7–B9).

Results
After excluding the 9 patients who withdrew, SVR12 rate according to per protocol analysis was 82.9% (92/111), non-response and relapse rates were 2.7% (3/111) for each, 4 patients died secondary to hematemesis, and 8.1% stopped therapy due to worsening of Child’s class. SVR12 rate was significantly higher among patients with higher baseline WBCs count and lower among patients with Child-Pugh class B9. All treatment intolerant patients had ascites in pre-treatment assessment (P = 0.02). There was a significant decline in the levels of hemoglobin, ALT and AST, and serum bilirubin (P < 0.001) and a significant increase in albumin level (P < 0.001) at the end of treatment when compared to their pre-treatment levels. Follow-up of the three HCC did not show evidence of tumor recurrence.

Conclusions
The SOF/DCV combination ± ribavirin is an effective and safe regimen for patients with CHC induced cirrhosis with mild decompensation. Treatment did not increase the risk of HCC recurrence.
Cost-effectiveness of psychosocial assessment for individuals who present to hospital following self-harm in England: A model-based retrospective analysis
Authors: McDaid David , Park A-La , Tsiachristas Apostolos , Brand Fiona , Casey Deborah , Clements Caroline , Geulayov Galit , Kapur Nav , Ness Jennifer , Waters Keith , Hawton Keith 
Published: January 2022

AbstractBackgroundGuidance in England recommends psychosocial assessment when presenting to hospital following self-harm but adherence is variable. There is some evidence suggesting that psychosocial assessment is associated with lower risk of subsequent presentation to hospital for self-harm, but the potential cost-effectiveness of psychosocial assessment for hospital-presenting self-harm is unknown.MethodsA three-state four-cycle Markov model was used to assess cost-effectiveness of psychosocial assessment after self-harm compared with no assessment over 2 years. Data on risk of subsequent self-harm and hospital costs of treating self-harm were drawn from the Multicentre Study of Self-Harm in England, while estimates of effectiveness of psychosocial assessment on risk of self-harm, quality of life, and other costs were drawn from literature. Incremental cost-effectiveness ratios (ICERs) for cost per Quality Adjusted Life Year (QALY) gained were estimated. Parameter uncertainty was addressed in univariate and probabilistic sensitivity analyses.ResultsCost per QALY gained from psychosocial assessment was £10,962 (95% uncertainty interval [UI] £15,538–£9,219) from the National Health Service (NHS) perspective and £9,980 (95% UI £14,538–£6,938) from the societal perspective. Results were generally robust to changes in model assumptions. The probability of the ICER being below £20,000 per QALY gained was 78%, rising to 91% with a £30,000 threshold.ConclusionsPsychosocial assessment as implemented in the English NHS is likely to be cost-effective. This evidence could support adherence to NICE guidelines. However, further evidence is needed about the precise impacts of psychosocial assessment on self-harm repetition and costs to individuals and their families beyond immediate hospital stay.
Genetically inducible and reversible zebrafish model of systemic inflammation
Authors: Lanham Kevin A. , Nedden Megan L. , Wise Virginia E. , Taylor Michael R. 
Published: January 2022

ABSTRACT
The inflammatory response is a vital defense mechanism against trauma and pathogen induced damage, but equally important is its appropriate resolution. In some instances of severe trauma or sustained infection, inappropriate and persistent activation of the immune response can occur, resulting in a dangerous systemic inflammatory response. Untreated, this systemic inflammatory response can lead to tissue damage, organ shutdown, and death. Replicating this condition in tractable model organisms can provide insight into the mechanisms involved in the induction, maintenance, and resolution of inflammation. To that end, we developed a non-invasive, inducible, and reversible model of systemic inflammation in zebrafish. Using the Gal4-EcR/UAS system activated by the ecdysone analog tebufenozide, we generated transgenic zebrafish that allow for chemically induced, ubiquitous secretion of the mature form of zebrafish interleukin-1β (Il-1βmat) in both larval and adult developmental stages. To ensure a robust immune response, we attached a strong signal peptide from the Gaussia princeps luciferase enzyme to promote active secretion of the cytokine. We observe a dose-dependent inflammatory response involving neutrophil expansion accompanied by tissue damage and reduced survival. Washout of tebufenozide permits inflammation resolution. We also establish the utility of this model for the identification of small molecule anti-inflammatory compounds by treatment with the immunosuppressant rapamycin. Taken together, these features make this model a valuable new tool that can aid in identifying potential new therapies while broadening our understanding of systemic inflammation, its impact on the immune system, and its resolution.
Facile Synthesis of BiVO4 Nanorods by a Template Method
Authors: Jia Yulong , Yin Guoliang , Zhang Chenyang , Lin Yinhe , Ma Ying 
Published: January 2022

Abstract
BiVO4 nanorods are synthesized by using V2O5 nanorods as growth template and vanadium source. The outward diffusion of V2O5 nanorods and ion-exchange reaction between V2O5 and Bi(NO3)3 guarantee the fabrication of uniform BiVO4 nanorods. The morphology, crystal phase, and chemical states of samples are characterized. The result indicates that the V2O5 nanorods have a critical effect on the preparation of BiVO4 nanorods.
Catalytic Activity Comparison of Gold Nanoparticles in Annealed and Quenched Spherical Polyelectrolyte Brushes
Authors: Li Lingshan , Li Min , Qiu Zhiqiang , Chen Kaimin , Xu Yisheng , Guo Xuhong , Wang Jie 
Published: January 2022

Abstract
Two kinds of cationic spherical polyelectrolyte brushes (SPB), quenched poly(methacryloxyethyltrimethyl ammonium chloride) brush and annealed poly(2-aminoethyl methacrylate hydrochloride) brush with polystyrene cores (PS-PMETAC and PS-PAEMH), were synthesized by photo-emulsion polymerization. The small and uniform gold nanoparticles (AuNPs) were successfully immobilized in these two SPBs. The chain layer extension of the quenched SPB loaded with AuNPs (SPB-Au) was more complete than that of the annealed SPB-Au in alkaline system. Compared the catalysis of the prepared AuNPs onto the two SPBs, it was found that the catalytic activity of AuNPs in quenched SPB is higher than that in annealed SPB.
In Situ Generation of Catalytically Active Cu0 Species Derived from Cu-Al Layered Double Hydroxides for Acceptorless Alcohol Dehydrogenation
Authors: Kurniawan Enggah , Hara Takayoshi , Permana Yessi , Ichikuni Nobuyuki , Shimazu Shogo 
Published: January 2022

Abstract
A CuO-CuAl2O4 nanocomposite (CuAl NC) synthesized by high temperature calcination of Cu-Al layered double hydroxides (CuAl LDHs) acted as an effective heterogeneous catalyst for acceptorless dehydrogenation of various alcohols. The catalytically active Cu0 species was formed by in situ reduction with alcohol. The catalytic activity strongly depended on the Cu/Al ratio in preparation and calcination temperature. The synthesized catalyst was reusable without loss of its high activity and selectivity.
Novel Environmentally Friendly Blue Pigments Based on Na4Cu(PO4)2
Authors: Shirai Hiroaki , Tamura Shinji , Imanaka Nobuhito 
Published: January 2022

Abstract
Novel environmentally friendly blue pigments, Na4Cu1−xMgx(PO4)2 (0 ≤ x ≤ 0.25), were synthesized. By doping Mg2+ with lower electronegativity into Cu2+ sites, the crystal lattice was distorted, which strongly affects the charge transfer from O2− to Cu2+ and the d–d transition of Cu2+. In the series of Na4Cu1−xMgx(PO4)2, the Na4Cu0.85Mg0.15(PO4)2 solid showed a vivid blue hue with a blueness value (−b*) of 38.2 in the CIE L*a*b* system.
Quality of information in news media reports about the effects of health interventions: Systematic review and meta-analyses
Authors: Oxman Matt , Larun Lillebeth , Pérez Gaxiola Giordano , Alsaid Dima , Qasim Anila , Rose Christopher James , Bischoff Karin , Oxman Andrew David 
Published: January 2022

Background Many studies have assessed the quality of news reports about the effects of health interventions, but there has been no systematic review of such studies or meta-analysis of their results. We aimed to fill this gap (PROSPERO ID: CRD42018095032). Methods We included studies that used at least one explicit, prespecified and generic criterion to assess the quality of news reports in print, broadcast, or online news media, and specified the sampling frame, and the selection criteria and technique. We assessed criteria individually for inclusion in the meta-analyses, excluding ineligible criteria and criteria with inadequately reported results. We mapped and grouped criteria to facilitate evidence synthesis. Where possible, we extracted the proportion of news reports meeting the included criterion. We performed meta-analyses using a random effects model to estimate such proportions for individual criteria and some criteria groups, and to characterise heterogeneity across studies. Results We included 44 primary studies in the review, and 18 studies and 108 quality criteria in the meta-analyses. Many news reports gave an unbalanced and oversimplified picture of the potential consequences of interventions. A limited number mention or adequately address conflicts of interest (22%; 95% CI 7%-49%) (low certainty), alternative interventions (36%; 95% CI 26%-47%) (moderate certainty), potential harms (40%; 95% CI 23%-61%) (low certainty), or costs (18%; 95% CI 12%-28%) (moderate certainty), or quantify effects (53%; 95% CI 36%-69%) (low certainty) or report absolute effects (17%; 95% CI 4%-49%) (low certainty). Discussion There is room for improving health news, but it is logically more important to improve the public’s ability to critically appraise health information and make judgements for themselves.
A case series of ocular involvement in bullous pemphigoid: clinical features, management, and outcomes
Authors: Kate Anahita , Shanbhag Swapna , Donthineni Pragnya Rao , Basu Sayan 
Published: January 2022

Ocular involvement in cases of bullous pemphigoid is rare and when present, the signs are usually subtle and in the form of fine tarsal scarring and dry eye disease. The current report aims to describe the clinical features and management protocols in a series of cases with aggressive ocular manifestations at presentation. All cases of bullous pemphigoid seen between 2017 and 2020 were included in this retrospective case series. Data regarding the clinical features, treatment administered, and outcomes was collected. Five cases (n=10 eyes) of bullous pemphigoid disease with ocular involvement were included. All eyes had significant cicatricial conjunctival changes in the form of symblephara, inferior forniceal shortening, and tarsal conjunctival scarring. Conjunctival granulomas were present in 3/10 eyes. Corneal involvement in the form of punctate keratitis was present in all eyes while 4/10 eyes had an epithelial defect as well. The management of these cases involved topical therapy with corticosteroids and lubricants (n=10 eyes) while pulse doses of intravenous methyl prednisolone were administered in 5/5 cases. Pulse intravenous cyclophosphamide was supplemented in 2/5 cases. Adequate control of the disease was noted in 3/5 cases while one case had a recalcitrant form of the disease and developed a dermalised ocular surface in both eyes. The last patient was lost to follow up during the course of therapy. Bullous pemphigoid can present with an aggressive form of cicatrizing conjunctivitis similar to other variants of autoimmune blistering disorders and must be considered as a differential in cases presenting with ocular cicatricial disease. Long-term intensive immunosuppression is required for the management of these cases to preserve the visual function and the integrity of the globe.
Assessment of fear, anxiety, obsession and functional impairment of COVID-19 amongst health-care workers and trainees: A cross-sectional study in Nepal
Authors: Atreya Alok , Nepal Samata , Menezes Ritesh G , Shurjeel Qazi , Qazi Sana , Ram Muskaan Doulat , Usman Muhammad Shariq , Ghimire Sristi , Marhatta Anu , Islam Md Nazmul , Sapkota Arbin Dev , Garbuja Chandra Kumari 
Published: January 2022

Background: The emergence of the COVID-19 epidemic threw the world into turmoil. The medical community bore the brunt of the pandemic's toll. Long work hours, and a lack of personal protective equipment (PPE) and social support all had an influence on mental health. Methods: This cross-sectional study was conducted among Lumbini Medical College Teaching Hospital students and employees in Palpa, Nepal. Data entailing their demographic details, pre-existing comorbidities, or death in the family due to COVID-19 was collected using a self-administered survey. In addition, the level of fear, anxiety, obsession, and functional impairment due to COVID-19 was recorded using previously validated respective scales. Results: In total, 403 health-care workers and trainees participated in our study. The average age of the study participants was 23±4 years, and more than half of them (n=262, 65%) were females. A significant association was found between fear score with age (p-value=0.04), gender (p-value <0.01) and occupation (p-value<0.001). The participants suffering from chronic diseases (p-value=0.36), and those who had experienced a COVID-19 death in the family (p-value=0.18), were not found to be significantly obsessed with COVID-19. However, for those who had experienced a COVID-19 death in the family (p-value=0.51) and age (p-value=0.34), these factors were not found to be significantly associated with higher anxiety levels. Nursing students suffered from a significantly greater functional impairment than other medical professionals (mean score=269.15, p-value < 0.001). A moderately positive correlation was observed between fear, anxiety, obsession, and functional impairment scales. Conclusion: This study revealed various socio-demographic characteristics as risk factors for psychological stress in the people related to the health-care profession of Nepal during the COVID-19 pandemic. A viable answer to this quandary might be adequate psychosocial intervention by health-care authorities, increased social support, and the introduction of better mental health management measures for the front-line medical workers.
Using the Mothers Object Relations Scale for early childhood development research in rural India: Findings from the Early Life Stress Sub-study of the SPRING Cluster Randomised Controlled Trial (SPRING-ELS)
Authors: Bhopal Sunil S. , Roy Reetabrata , Verma Deepali , Kumar Divya , Khan Bushra , Soremekun Seyi , Oates John , Divan Gauri , Kirkwood Betty R. 
Published: January 2022

Background: The World Health Organization and others promote responsive caregiving to support all children to thrive, particularly in low- and middle-income countries. The 14-item Mother’s Object Relations Scales – Short Form (MORS-SF) may be of use in research and public health programmes because of its basis in attachment theory and ability to capture parental feelings towards their child. Methods: We culturally adapted the MORS-SF for use with mothers in the SPRING home visits trial when their infants were 12 months old. The same dyads were assessed using the HOME inventory concurrently and Bayley Scales of Infant Development III (BSID-III) at 18 months of age. Mixed effects linear regression was used to examine associations between MORS-SF (explanatory variable) and HOME-IT, and the cognitive, language and motor domains of BSID-III (outcome variables). Results: 1273 dyads completed all assessments. For the motor and language BSID-III scales and for HOME-IT there were strong and positive associations with the MORS-SF warmth sub-scale, and strong and negative associations with the invasion sub-scale. Important but less strong associations were seen with the BSID-III cognitive scale. Evidence of interaction suggested that both are individually important for child development. Conclusions: This is the first time MORS-SF has been used in India where optimising responsive caregiving is of importance in supporting all children to reach their potential. It is also the first time that the tool has been used in relation to child development. MORS-SF could be a valuable addition to evaluation in early childhood development.
The Impact of COVID-19 Pandemic on the (Un)popularity of Higher Tourism Education in Poland
Authors: Rozmiarek Mateusz , Malchrowicz-Mośko Ewa 
Published: January 2022

Along with the development of tourism activities, universities educating students in the fields of tourism and recreation take over the responsibility for preparing a qualified and skilled workforce that can provide the society with high-quality services. The aim of the article was to attempt to assess the impact of the COVID-19 pandemic on the popularity or unpopularity of tourist faculties at Polish physical education universities. Five out of six public universities of physical education in Poland, which offer undergraduate and graduate studies in tourism and recreation were asked to provide data on the number of students who enrolled in the first and second cycle studies in the field of tourism and recreation in the last six years, as well as the number of students who resigned during the first year or after its completion. The results showed a decline in interest in studying tourism and recreation after the 2016/2017 academic year, which covers all physical education universities in Poland. Although there may be many reasons for this, it is necessary to try to find a solution to the current problems and restore interest in studying tourism.
Análisis comparativo de los sistemas de justicia administrativa en América Latina
Authors: Perlingeiro Ricardo 
Published: January 2022

El presente ensayo consiste en un análisis comparativo respecto a las tradiciones de derecho administrativo en América Latina, y su impacto en el escenario contemporáneo, al igual que sobre las tendencias en las orientaciones generales de sus sistemas de justicia administrativa. El método que se sigue consiste en señalar las atribuciones de las autoridades administrativas y tratar de identificar la distinción, en América Latina, entre la "función administrativa de implementación" (administrative function of implementation), el "control de la legalidad de las decisiones administrativas" (no relacionado con función jurisdiccional alguna ) y la "protección de derechos" (por medio de una función jurisdiccional), mientras examinamos su génesis histórica y sus tendencias futuras. En esta perspectiva, el texto aborda los poderes administrativos y sus límites; las prerrogativas e instrumentos de las autoridades en el ejercicio de sus funciones de aplicación; el control de las decisiones administrativas por las propias autoridades administrativas y también por órganos externos; así como la protección judicial y extrajudicial de derechos frente a decisiones administrativas.