bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kb-Ks tephra found in lake sediments in the Jeokjung-Chogye Basin, which was formed by a meteorite impact, and its geological implications
Authors: Shin Seungwon , Lee Jin-Young , Hong S.S. , Kim C.-B. , Lim Hyoun S. , Nahm W.H. 
Published: November 2022

Abstract
It was recently reported that a Quaternary basin in southeastern Korea was formed by a meteorite impact, and a 12-cm-thick tephra layer was found in lake sediments in this basin. In this study, we analyzed the geochemical composition and refractive index of glass shards to identify the unknown tephra. Based on both results, this tephra was identified as Kb-Ks tephra that erupted in the Kyushu area, Japan, approximately 520 ka. To our knowledge, this is the first report of Kb-Ks tephra in terrestrial sediments in the Korean Peninsula. These findings indicate that the depositional age of the lake sediments is much older than previously suspected (ca. 63 ka), and that the meteorite impact occurred before 520 ka. Although more detailed studies are needed, the discovery of Kb-Ks tephra provides important information concerning the paleoclimate during the middle Pleistocene, as well as the prediction of volcanic hazards in the Korean Peninsula.
KBeagle: An Adaptive Strategy and Tool for Improvement of Imputation Accuracy and Computing Efficiency
Authors: Wang Jiabo , Qin Jie , Liu Xinrui , Liu Yaxin , Wei Peng , Kangzhu Yixi , Zhong Jincheng 
Published: November 2022

Abstract
With the development of molecular biology and genetics, deep sequencing technology has become the main way to discover genetic variation and reveal the molecular structure of genome. Due to the complexity of the whole genome segment structure, a large number of missing genotypes have appeared after sequencing, and these missing genotypes can be imputed by genotype imputation method. With the in-depth study of genotype imputation methods, computational intensive and computationally efficient imputation software come into being. Beagle software, as an efficient imputation software, is widely used because of its advantages of low memory consumption, fast running speed and relatively high imputation accuracy. K-Means clustering can divide individuals with similar population structure into a class, so that individuals in the same class can share longer haplotype fragments. Therefore, combining K-Means clustering algorithm with Beagle software can improve the interpolation accuracy. The Beagle and KBeagle method was used to compare the imputation efficiency. The KBeagle method presents a higher imputation matching rate and a shorter computing time. In the genome selection and heritability estimated section, the genotype dataset after imputed, unimputed, and with real genotype show similar prediction accuracy. However the estimated heritability using genotype dataset after imputed is closer to the estimation by the dataset with real genotype. We generated a compounds and efficient imputation method, which presents valuable resource for improvement of imputation accuracy and computing time. We envisage the application of KBeagle will be focus on the livestock sequencing study under strong genetic structure.
Right-Side Shift of Colorectal Cancer in Trinidad &amp;Tobago: Correcting the Record
Authors: Cawich Shamir O. , Muddeen Alyssa , Barrow Mikhail , Capildeo Kavi D. , Bhim Nazreen , Barrow Shaheeba 
Published: November 2022

Abstract
Purpose: Previously published epidemiologic data from Trinidad & Tobago suggested that left-sided colorectal cancer (CRC) was more common, but accepted, standardized definitions for CRC laterality were not used. We carried out this study to collect data from patients with CRC in Trinidad & Tobago in order to determine anatomic site using standardized definitions.
Methods: We carried out a retrospective audit of hospital records for all patients with CRC over a 10-year period from January 1, 2011 to January 30, 2021. Standardized definitions were used to classify CRC laterality: Right-sided CRC was defined as those that arose in the cecum, ascending colon, hepatic flexure and/or transverse colon. Left-sided primaries were defined as those that originated from the splenic flexure, descending colon and/or sigmoid colon. The following data were extracted: laterality, gender, age and ethnicity. Descriptive statistical analyses were generated with SPSS version 21.
Results: The records of 326 patients with CRC were examined in this study. There was a predominance of right-sided (43%) over left sided primaries. There was a statistically significant relationship between right sided CRC and female gender (58.2% vs 41.8%; P=0.00168), black ethnicity (60.2% vs 38.6%; P=0.0076) and younger age (60.9 vs 65.9 years; P=0.00028).
Conclusions: There is a predominance of right-sided CRC in this eastern Caribbean nation, significantly associated with younger age, female gender and black ethnicity.
The Role of Remote Sensing and Geographic Information System in Analyzing Climate Change in the Mesopotamian Marchlands, Iraq
Authors: Khalid Nazar Jameel , Farajzadeh Manuchehr 
Published: November 2022

Abstract
The world's most essential natural environmental resources are the wetlands. Therefore, in Iraq, the Mesopotamia marshes are considered as the utmost significant swamplands worldwide. They are situated in the massive water meadow of Rivers Tigris and Euphrates in the lower basin of Mesopotamia. In this paper there will be a thoughtful study for the effect of climate and microclimate changing on these Marshes. Since, remote sensing tends to be the most effective approach as it is less costly and consumes fewer time, the Advanced, Very High-Resolution Radiometer is found in polar-orbiting ecological satellites to estimate NDVI the Normalized Difference Vegetation Index. Essentially, two ethereal stations located on sensor NOAA was conducted on three different marshes in the study area. A time-series observation of the AVHRR/NDVI for the period 1982-2017 of the three marshes enumerated the vagaries in the ecosystem to help determine hydrology and vegetation. The water system in Iraq is experiencing significant challenges, thus increasing concerns about the Mesopotamian marshes that have been sustaining the region for thousands of years that are likely to disappear soon.
Emotional brain activation across the menstrual cycle in women with premenstrual dysphoric disorder and associations to serum levels of progesterone-derived neurosteroids
Authors: Stiernman Louise , Dubol Manon , Comasco Erika , Sundström-Poromaa Inger , Boraxbekk Carl-Johan , Johansson Maja , Bixo Marie 
Published: November 2022

Abstract
Premenstrual dysphoric disorder (PMDD) is a debilitating disorder characterized by severe mood symptoms in the luteal phase of the menstrual cycle. Allopregnanolone (ALLO), a GABAA-modulating progesterone metabolite, is hypothesized to contribute to the development of PMDD symptoms. On the other hand, the endogenous 3\(\beta\)-epimer of ALLO, isoallopregnanolone (ISO), has been shown to alleviate PMDD symptoms through its selective inhibitory modulation of the ALLO effect. There is preliminary evidence showing altered recruitment of brain regions during emotional processing in PMDD, but whether there is some relation to ALLO or ISO is unknown. In the present study, women with PMDD and asymptomatic controls underwent functional magnetic resonance imaging (fMRI) in the mid-follicular and the late-luteal phase of the menstrual cycle. Brain responses to emotional stimuli were investigated and related to serum levels of ovarian steroids (estradiol, progesterone) and the neurosteroids ALLO, ISO, and their ratio ISO/ALLO. Women with PMDD exhibited greater activity in brain regions which are part of emotion processing networks during the late-luteal phase of the menstrual cycle. Furthermore, activity in key regions of emotional networks - the parahippocampal gyrus and amygdala - was differentially associated to the ratio of ISO/ALLO levels in PMDD and control women. Specifically, positive relationships between ISO/ALLO levels and brain activity were found in PMDD women, while the opposite was observed in controls. In conclusion, women with PMDD show altered emotional brain responses in the late-luteal phase of the menstrual cycle which may be related to an altered response to GABAA-active neurosteroids.
Suffering Despite Fleeing Acute Stress Disorder among Ukrainian War Refugees in Europe
Authors: Kordel Piotr , Rządeczka Marcin , Studenna-Skrukwa Marta , Kwiatkowska-Moskalewicz Katarzyna , Goncharenko Olga , Moskalewicz Marcin 
Published: November 2022

Abstract
Fleeing from war, witnessing death and destruction and leaving family behind can be frightening, stressful and result in Acute Stress Disorder (ASD), a mental health condition that can occur in the first month after a traumatic event.
This cross-sectional study of 637 Ukrainian war refugees used two structured surveys. The first consisted of questions regarding demography, the circumstances of the refuge, pre-2/24 2022 traumas and autoimmune diseases, and experiences in the host country. The second instrument was the Acute Stress Disorder Scale.
The prevalence of ASD among refugees was high (93.5%). Several factors increasing the risk of developing ASD were identified, e.g. witnessing Russian attacks, OR 2.92, 95% CI 1.26-6.78, insufficient financial resources, OR 3.56, 95% CI 1.61- 7.91, feeling of loneliness in the host country OR 3.07, 95% CI 1.58-8.69). Pre-existing depression, death of a close person, a spouse left in Ukraine, among others, were found to significantly (p<0.05) exacerbate the ASD symptoms.
The study shows the extreme levels of trauma among the Ukrainian war refugees. The knowledge regarding ASD vulnerabilities in the present conflict (women, witnesses of attacks, depressed, lonely, and discriminated) may facilitate prompt and adequate psychological help. Since ASD is an antecedent of PTSD and several autoimmune disorders, these results may also serve as a predictor of future challenges for the Ukrainian Society
Cost-utility analysis of triplet therapy using gemcitabine, cisplatin, and S-1 for the primary treatment of advanced biliary tract cancer.
Authors: kashiwa munenobu , Matsushita Ryo 
Published: November 2022

Abstract

Background

The results of the KHBO1401-MITSUBA trial suggested the effectiveness of triplet therapy using gemcitabine, cisplatin, and S-1; however, the cost-effectiveness of this treatment regimen remains unclear.

Aim

We conducted a cost-utility analysis comparing triplet therapy using gemcitabine, cisplatin, and S-1 and doublet therapy using gemcitabine and cisplatin for advanced biliary tract cancer from the perspective of a Japanese healthcare payer to investigate the economic sustainability of healthcare interventions.

Method

Based on the results of the KHBO1401-MITSUBA clinical trial, a partitioned survival model set over a 10-year time horizon was developed. Cost and utility data were sourced from earlier studies. Health outcomes were measured as quality-adjusted life-years. Direct medical costs included drug costs and medical fees. The uncertainty and robustness of the model were evaluated using one-way and probabilistic sensitivity analyses. The willingness-to-pay threshold was set at 7.5 million Japanese yen.

Results

Base case analysis revealed that the incremental cost-effectiveness ratio for triplet therapy was 5,257,388 Japanese yen (47,881 United States dollars) per quality-adjusted life-year. The one-way sensitivity analysis indicated that parameters influencing the overall survival curve for doublet and triplet therapy affected the incremental cost-effectiveness ratio. Probabilistic sensitivity analysis suggested that triplet therapy had a 72.5 % chance of being cost-effective at a willingness-to-pay threshold of 7.5 million yen per quality-adjusted life-year.

Conclusion

Triplet therapy using gemcitabine, cisplatin, and S-1 is cost-effective in the primary treatment of biliary tract cancer in the Japanese healthcare system.
Effect of Kappa Distribution Function with Temperature Anisotropy on Firehose Instability in Earth’s Magneto-Plasma
Authors: Tandon Neeti , Ahirwar Ganpat 
Published: November 2022

Abstract
The firehose instability (FHI) has been studied by kinetic approach with Kappa distribution function in auroral acceleration region of the magnetosphere. The combined effect of temperature anisotropy for ions, electrons, and dust particles, which are responsible to drive firehose instability, is modeled through non-maxwellian Kappa distribution function. The kinetic Vlasove-Maxwell equations are used to describe the dispersion nature of the firehose mode. In the high beta homogenous plasma by applying Kappa distribution function, dispersion relation, growth rate and growth length have been investigated. The effect of spectral index kappa have been studied on FHI. The range of beta parameter and anisotropy is analyzed at different fixed value of kappa index. It is considered that the instability is propagating along the background guiding magnetic field. The interpretation of the analytical results, have been done on the plasma parameters of auroral acceleration region, which is a part of the earth's magnetosphere. The result and analysis may be extended to multi component plasma and in low beta plasma also.
Family Connections vs Treatment at Usual Optimized in the treatment of relatives of people with eating disorders and personality disorders: Study protocol of a randomized control trial
Authors: Guillén Verónica , Pérez Sandra , Garcia-Alandete Joaquín , Fernandez-Felipe Isabel , Marco Jose Heliodoro 
Published: November 2022

Abstract
Background

Family members of patients with eating disorders (ED) often experience high levels of burden, suffering, grief, and helplessness. If, in addition to ED, the patient has a personality disorder (PD), the psychological distress experienced by family members can be devastating. However, few treatments have been developed for family members of people with ED and PD. Family Connections (FC) is a program that has been shown to be effective in relatives of people with borderline personality disorder. The general objectives of this research project are: (a) to adapt and test the FC intervention protocol designed specifically for family members of patients with ED-PD in the Spanish population (FC: ED-PD); (b) to analyze, in a randomized controlled trial, the efficacy of the FC: ED-PD program versus a control condition consisting of optimized treatment as usual (TAU-O); (c) to analyze the feasibility and acceptability of the intervention protocol; (d) to analyze whether the changes that may occur in family members are related to improvements in the family climate and/or improvements observed in patients; and (e) to analyze the perceptions and opinions of families and patients about the two intervention protocols.

Methods

The study design consists of a two-arm randomized controlled trial with two conditions: FC: ED-PD or Treatment as usual optimized (TAU-O). Participants will be relatives of patients who meet DSM-5 criteria for ED and PD or dysfunctional personality traits. Participants will be assessed at pre- and post-treatment and one-year follow-up. The intention-to-treat principle will be used when analyzing the data.

Discussion

These results will also confirm the program’s efficacy and acceptance by family members.

Trial registration

ClinicalTrials.gov Identifier: NCT05404035. Accepted: May 2022.
Cross-Chain Interoperability - Validating Smart Contracts to Interoperate Over Diverse Blockchain Networks Using Interoperable Blockchain Framework Design (IBFD)
Authors: Helal Maha , Alsoud Anas Ratib , Alshareef Hazzaa 
Published: November 2022

Abstract
Blockchain technology is meant to perform a potential act to intensify the performance of several information systems. In this view, the platforms and the applications adapted for blockchain must be competitive to communicate and connect. The current blockchain platforms have many limitations, such as interoperability issues in divergent systems. The present platforms of blockchain applications work only within their networks. Blockchain interoperability allows data and values to be sent across various networks. The fundamental technology may be homogeneous, still, it relies on third-party intermediaries using the centralized mechanism to retrieve or exchange data from various interacting blockchain networks. The existing intermediaries incorporate security and trust by maintaining a centralized ledger to monitor ‘account balances’ and verify a transaction’s authenticity. The incompetence of individual and independent blockchains to interact with each other is an ingrained issue in decentralized systems. Cross-Chain Interoperability Protocol (CCIP) and similar mechanisms support networks like Fabric, Ripple and Ethereum to interrelate and interoperate each other. It is identified that the shortfall in such significant inter-blockchain communication creates a hassle for the mainstream adoption of blockchain. The article discusses different techniques and methods that provide cross-chain interoperability, its significant features and its applications in blockchain technology. It proposes the Inter-operable Blockchain Framework Design (IBFD), a cross blockchain architecture for interoperability of blockchain networks.
Whether misuse the oral hygiene may facilitate the speared of Covid 19 among cohabiting individual?
Authors: Bashardoust Nazanin , mahmoudzadeh Masoumeh , Khoshtarash Mehrnoosh , Mirfarhadi Nastaran 
Published: November 2022

Abstract
Background
Despite all the existing guidelines regarding Covid-19, there has been less emphasis on oral care to reduce the amount of virus in the mouth and saliva and thus reduce the risk of transmission of this disease. The purpose of this study is to investigate oral hygiene habits and infection control behaviors and their relationship with the rate of family transmission in patients with covid-19.
Methods
In this cross-sectional analytical study, 179 patients with covid-19 referred to the Razi Medical Training Center in Rasht were examined in the form of continuous sampling in 1400–1401. The data collection tool is a 3-part questionnaire including 1) personal social and clinical information of a person infected with Covid-19, basic information from family members in contact with the infected person, and transfer to another person in the family 2) oral hygiene habits during quarantine 3) infection control behaviors. To analyze the collected data, independent t-tests, ANOVA, and Spearman's correlation were used for quantitative variables, and the Chi-square test was used for qualitative variables in SPSS software version 28, and the level of significance in all tests was 0.05.
Results
The findings showed that the rate of family transmission of the disease was 61.5%. There was no significant relationship between oral hygiene habits with the family transmission of Covid-19 (p = 0.108), but the use of a shared toothbrush container and a shared toothpaste tube among family members was significantly related to the rate of family transmission (p = 0.042 and p > 0.001, respectively)
Conclusions
There was no relationship between oral hygiene habits and the transmission of covid-19 disease in family members, but oral hygiene habits were effective in contracting a more severe form of the disease and the rate of hospitalization. The use of toothbrush containers and toothpaste tubes shared between family members increased the chance of family transmission of covid-19.
TACE plus PD-1 successfully achieves conversion therapy for unresectable HCC with multiple macrovascular invasion: a case report
Authors: Guo Bin , Zhou Yi , Ouyang Tianhua , Liu Zhicheng , Xia Feng , Chen Qian , Chen Xiaoping , Xiao Zhenyu 
Published: November 2022

Abstract
Background
There is still a lack of effective treatment for patients with advanced hepatocellular carcinoma (HCC) and macrovascular invasion, and surgical resection is technically feasible but difficult to remove the tumor completely, which often leads to early recurrence. In recent years, it has been found that the combination of systematic therapy and locoregional treatment has shown better anti-tumor effect for advanced HCC than a single drug or method. Higher objective response rate with combined therapy brings new hope for conversion therapy as well.
Case presentation
A 32-year-old male patient was diagnosed with giant HCC with tumor thrombus formation in the right branch of the portal vein, inferior vena cava, and right atrium. After receiving 3 times transarterial chemoembolization combined with 7 cycles of PD-1 inhibitors treatment, the tumor significantly shrunk and the tumor thrombus in the inferior vena cava and right atrium disappeared. Finally, the patient underwent radical liver resection successfully. Now a year after surgery, the patient remains in disease-free survival.
Conclusion
TACE plus PD-1 inhibitors may be an ideal conversion regimen for patients with potentially resectable HCC, leading to more surgical resection opportunities. Neutrophil lymphocyte ratio decreased after treatment may suggest that patients respond well to PD-1-based combination therapy.
Blood Parameters in the Domestic Reindeer From the Yamalo-nenets Autonomous Okrug, Russia
Authors: Gavrichkin Alexander A. , Serkova Margarita I. , Silivanova Elena A. , Rjabov Sergey A. 
Published: November 2022

Abstract

The reindeer (Rangifer tarandus L.) has a great ecological and economic importance for northern regions. The domestic reindeer population in the Yamalo-Nenets Autonomous Okrug is the largest one in the Russian Federation. Due to the lack of published actual data on blood parameters and well-established their reference ranges for Russian reindeer populations, hematology and biochemistry of blood serum of 97 reindeer was studied in August of 2019. Domestic reindeer were grouped into seven groups according to sex and age at the grazing site in the tundra zone of the Priuralsky district, Russia. Animals were tested for tuberculosis and brucellosis and no positively reacting animals were recorded indicating the well-being of the herd at the time of the study. We observed no differences between males and females or between young and adult reindeer for most parameters. The sodium content in the serum was below 110 mmol/L in 29 (about 30%) animals out of 97 while the mean values of this parameter (namely from 127.8 ± 3.9 to 133.8 ± 2.2 mmol/L) for remaining 70% of animals were less compared to the published data. Also, we noted the low protein level (from 4.97 ± 0.62 to 6.44 ± 0.63 g/dL on average) and the increased phosphorus level (from 5.22±0.39 to 7.93±0.62 g/dL on average) the reindeer blood serum compared to the published data. The represented data might be useful to establish baseline hematologic and serum biochemical reference ranges for domestic reindeer in northern regions.