bluuebunny/crossref_metadata_2025_split huggingface dataset:
Language and Communication Deficits in Chromosome 16p11.2 Deletion Syndrome
Authors: Jiménez-Romero M Salud , Fernández-Urquiza Maite , Benítez-Burraco Antonio 
Published: November 2022

Purpose:
Chromosome 16p11.2 deletion syndrome (OMIM #611913) is a rare genetic condition resulting from the partial deletion of approximately 35 genes located at Chromosome 16. Affected people exhibit a variable clinical profile, featuring mild dysmorphisms, motor problems, developmental delay, mild intellectual disability (ID), socialization deficits and/or autism spectrum disorder (ASD) traits, and problems with language. Specifically, a precise characterization of the speech, language, and communication (dis)abilities of people with this condition is still pending.

Method:
We used standardized tests and samples of naturalistic speech to provide a longitudinal profile of the speech, language, and communication problems of a boy with Chromosome 16p11.2 deletion syndrome and without ID or ASD.

Results:
The proband shows impaired expressive abilities as well as problems with receptive language, dysprosody, and ASD-like communication deficits, such as impaired interactive skills, perseverative verbal behavior, overabundance of tangential responses, and lack of metapragmatic awareness and communicative use of gaze, meeting the criteria for social pragmatic communication disorder.

Conclusions:
Our results support the view that language and communication impairment should be regarded as one core symptom of Chromosome 16p11.2 deletion syndrome, even without a diagnosis of ASD or ID. Clinical implications of our results, with a focus on therapeutic interventions for children with 16p11.2 deletion syndrome and no ASD or ID, are also discussed.

Supplemental Material:

https://doi.org/10.23641/asha.21561714
Developing a Real-Time Test to Investigate Conversational Speech Understanding
Authors: Buchholz Joerg M. , Davis Chris , Beadle Julie , Kim Jeesun 
Published: November 2022

Purpose:
This study aimed to develop and test a measure of real-time continuous speech understanding to be used with natural dialogues.

Method:
The measure was based on a category monitoring paradigm and employed five existing recordings of natural dialogues from which the different test categories and associated target words were derived. For each dialogue, a listener was first given a semantic category and asked to press a button as quickly as possible whenever they heard an instance of the category. We tested 63 younger adults, using five semantic categories (family, media, season, temperature, and travel) at three noise levels (in quiet, 0 dB, and −5 dB signal-to-noise ratio [SNR]). Performance was measured in terms of accuracy and response time.

Results:
The results showed clear differences between the three noise conditions regardless of the semantic category. The peak of the response distribution was highest and earliest for the quiet condition and was reduced with decreasing SNR. The responses varied across categories, reflecting differences in the complexity of a given category or the typicality of the association between target words and their category. Broad categories and/or target words that were less directly associated with their category had decreased hit rates and increased response times.

Conclusion:
The results were discussed in terms of the sensitivity (hit rate) of the performance measure, as well as whether it picked up higher level semantic, context, and discourse properties of the dialogues.

Supplemental Material:

https://doi.org/10.23641/asha.21561681
Chasing ICM cooling and AGN feedback from the macro to the meso scales in the galaxy cluster ZwCl 235
Authors: Ubertosi F. , Gitti M. , Brighenti F. 
Published: November 2022

Aims. We aim to investigate the interplay between the intracluster medium (ICM) and the active galactic nucleus (AGN) in ZwCl 235, a galaxy cluster with high X-ray flux, an extended central radio galaxy, and evidence of multiphase gas at its center.
Methods. Using archival data from the Chandra telescope, the Very Large Array Sky Survey (VLASS), the LOFAR Two-metre Sky Survey (LOTSS), and the VLBA telescope, we performed a complete study of ZwCl 235, dissecting the dynamics of the ICM, the thermodynamic state of the central gas, and the properties of the brightest cluster galaxy (BCG). By means of radial profiles and 2D spectral maps, we measured the temperature, entropy, and cooling time of the ICM, and we compared the morphology of the central radio galaxy with the surrounding medium.
Results. We find evidence that ZwCl 235 is a sloshing cool core cluster in which the activity of the central galaxy has excavated a pair of cavities and possibly uplifted enriched gas to an altitude of ∼30 kpc. In the cluster core, the lowest entropy ICM is preferentially found in a 20 kpc-long filament tangential to the southern radio lobe of the AGN. We argue that the observed cool (∼1.3 keV) filament is likely produced by a combination of sloshing and stimulated ICM cooling, which may be fueling the central supermassive black hole. Additionally, we determined that the X-ray emission of the BCG originates from a ∼1.4 keV plasma kernel, which extends for 5 kpc in radius and has a short cooling time (∼240 Myr), and it could represent the thermal corona of the BCG.
Conclusions. Overall, we propose that several sources (the large-scale ICM, the low entropy filament, and the ∼1.4 keV kernel) of cold material are currently feeding the central AGN, and that the ICM cooling cycle expectations are met from the macro scales (between 5−100 kpc) to the meso scales (≤5 kpc) of AGN feedback.
GaiaData Release 3
Authors: Distefano E. , Lanzafame A. C. , Brugaletta E. , Holl B. , Lanza A. F. , Messina S. , Pagano I. , Audard M. , Jevardat de Fombelle G. , Lecoeur-Taibi I. , Mowlavi N. , Nienartowicz K. , Rimoldini L. , Evans D. W. , Riello M. , García-Lario P. , Gavras P. , Eyer L. 
Published: November 2022

Context.TheGaiathird Data Release (GDR3) presents a catalogue of 474 026 stars (detected by processing a sample of about 30 million late-type stars) with variability induced by magnetic activity. About 430 000 of these stars are newly discovered variables. For each star, the catalogue provides a list of about 70 parameters among which the most important are the stellar rotation periodP, the photometric amplitudeAof the rotational modulation signal, and the Pearson correlation coefficientr0between magnitude and colour variation.Aims.In the present paper we highlight some features of theGaiaphotometric time series used to obtain the catalogue and we present the main attributes of the catalogue.Methods.The Specific Objects Study (SOS) pipeline, developed to characterise magnetically active stars withGaiadata, was described in the paper accompanying theGaiasecond rata release (DR2). Here we describe the changes made to the pipeline and a new method developed to analyseGaiatime series and to reveal spurious signals induced by instrumental effects or by the peculiar nature of the investigated stellar source. Such a method is based on the measurement of the per-transit-corrected-excess-factor (c*) for each time-series transit, wherec* is a parameter that allows us to check the consistency betweenG,GBP, andGRPfluxes in a given transit.Results.The period–amplitude diagram obtained with the DR3 data confirms the DR2 findings that is, the existence of a family of low-amplitude fast rotators never seen by previous surveys. The GDR3 data permit, for the first time, the analysis of patterns in magnitude–colour variation for thousands of magnetically active stars. The measuredr0values are tightly correlated with the star positions in the period–amplitude diagram.Conclusions.The relationship between theP,A, andr0parameters inferred for thousands of stars are potentially very useful for improving our understanding of stellar magnetic fields and ameliorating theoretical models, especially in the fast rotation regime. The method developed to reveal the spurious signals can be applied to each of the releasedGaiaphotometric time series and can be exploited by anyone interested in working directly withGaiatime series.
Observations and modeling of spectral line asymmetries in stellar flares
Authors: Wollmann J. , Heinzel P. , Kabáth P. 
Published: November 2022

Context. Stellar flares are energetic events occurring in stellar atmospheres. They have been observed on various stars using photometric light curves and spectra. On some cool stars, flares tend to release substantially more energy than solar flares. Spectroscopic observations have revealed that some spectral lines exhibit asymmetry in their profile in addition to an enhancement and broadening. Asymmetries with enhanced blue wings are often associated with coronal mass ejections, while the origin of red asymmetries is currently not well understood. A few mechanisms have been suggested, but no modeling has been performed so far.
Aims. We observed the dMe star AD Leo using the 2-meter Perek telescope at Ondřejov observatory, with simultaneous photometric light curves. In analogy with solar flares, we modeled the Hα line emergent from an extensive arcade of cool flare loops and explain the observed asymmetries using the concept of coronal rain.
Methods. We solved the non-LTE (departures from local thermal equilibrium) radiative transfer in Hα within cool flare loops taking the velocity distribution of individual rain clouds into account. For a flare occurring at the center of the stellar disk, we then integrated radiation emergent from the whole arcade to obtain the flux from the loop area.
Results. We observed two flares in the Hα line that exhibit a red wing asymmetry corresponding to velocities up to 50 km s−1 during the gradual phase of the flare. Synthetic profiles generated from the model of coronal rain have enhanced red wings that are quite compatible with observations.
Acoustic response in the transition region to transverse oscillations in a solar coronal loop
Authors: White S. J. , Verwichte E. 
Published: November 2022

Context. Magnetohydrodynamic (MHD) waves play an important role in the dynamics and heating of the solar corona. Transverse (Alfvénic) oscillations of loops commonly occur in response to solar eruptions and are mostly studied in isolation. However, acoustic coupling has been shown to be readily observable in the form of propagating intensity variations at the loop footpoints.
Aims. We extend the modelling of wave coupling between a transverse loop oscillation and slow magnetoacoustic waves in a structured loop to include a lower atmosphere.
Methods. We achieve this with combined analytical modelling and fully non-linear MHD simulations.
Results. Transverse loop oscillations result in the excitation of propagating slow waves from the top of the transition region and the lower boundary. The rate of excitation for the upward propagating waves at the lower boundary is smaller than for waves at the top of the transition region due to the reduced local sound speed. Additionally, slow waves are found to propagate downwards from the transition region, which reflect at the lower boundary and interfere with the upward propagating waves. Resonances are present in the normal mode analysis but these do not appear in the simulations. Due to the presence of the transition region, additional longitudinal harmonics lead to a narrower slow wave profile. The slow wave field is anti-symmetric in the direction of wave polarisation, which highlights the importance that the loop orientation has on the observability of these waves. The ponderomotive effect must be accounted for when interpreting intensity oscillations. Evidence is found for an additional short-period oscillation, which is likely a hybrid mode.
Samarium-Promoted Homocoupling of Benzaldehydes and In Situ Condensation with Esters Under the Catalysis of Cuprous Iodide
Authors: Liu Yongjun , Chen Hongping , Song Bin , Mi Mingzhong , Qi Yan 
Published: November 2022

AbstractA novel C–H functionalization method was successfully explored by a reductive three molecule coupling of benzaldehydes and esters mediated by samarium and cuprous iodide; thus, the diarylmethanol skeletons were afforded readily via an in situ esterification in one-pot. Substrates including a variety of esters and different benzaldehydes were investigated, and the desired products were readily obtained in moderate to good yields under mild conditions.
Transformation of Tetrafluoroethylene Using Transition-Metal Complexes
Authors: Ogoshi Sensuke , Doi Ryohei , Zhou Yuyang 
Published: November 2022

AbstractTetrafluoroethylene (TFE) is an industrial organofluorine feedstock that is used predominantly to fabricate fluorinated polymers. TFE exhibits excellent potential as a building block for synthesizing organofluorine compounds, which are increasingly gaining attention as functional materials, pharmaceuticals, and agrochemicals. In particular, the use of transition-metal complexes in the transformation of TFE is of great interest, considering their widespread use in syntheses of organofluorine compounds over the last few decades. This review highlights studies on the transformation of TFE into organofluorine compounds using transition-metal complexes, except for polymerizations. Our review covers cross-coupling reactions via C–F bond cleavage, fluoroalkylation reactions, multicomponent couplings, and olefin metathesis.1 Introduction2 Palladium Complexes3 Copper Complexes4 Nickel Complexes5 Ruthenium Complexes6 Rhodium Complexes7 Summary and Perspective
Need for adjunctive removal techniques for endoscopic mucosal resection of large non-pedunculated colonic polyps is predictive of recurrence
Authors: Li Suqing , Mosko Jeffrey , May Gary , Kandel Gabor , Kortan Paul , Marcon Norman , Teshima Christopher 
Published: November 2022

Abstract
Background and study aims Endoscopic mucosal resection (EMR) allows for safe and effective removal of large non-pedunculated colon polyps, but recurrence remains a significant concern. Risk factors for recurrence have previously been reported, however, the significance of these factors have varied and has uncertain applicability with recent advances in EMR techniques. We aimed to evaluate rates and risk factors for recurrence in recent years from a major Canadian referral center.
Patients and methods Consecutive patients between April 1, 2017 and March 1, 2019 who underwent piecemeal EMR were retrospectively identified. Patients with non-pedunculated colorectal polyps ≥ 2 cm removed by piecemeal EMR with available follow-up data were included.
Results Five hundred and seventeen patients were reviewed, with 265 patients satisfying inclusion criteria. The median age was 67 years (IQR 14); 48 % were female. 15 % had a recurrence on follow-up endoscopy. Adjunctive removal techniques were utilized in 31 % of patients, 95 % of which was hot avulsion. The use of adjunctive removal techniques (OR 2.87, P = 0.004) and male gender (OR 3.31, P = 0.003) was significantly predictive of recurrence on multivariate analysis. Receiver operating curve characteristics demonstrated good performance of these factors in predicting recurrence (area under the curve = 0.70).
Conclusions The use of adjunctive removal techniques, particularly hot avulsion and male gender are predictive of recurrence after piecemeal EMR of large non-pedunculated colorectal polyps. Male patients and those who require hot avulsion may be considered high risk for recurrence and warrant closer follow-up.
A Retrospective Study of the Profile and Outcome of Children with Dravet Syndrome in a Tertiary Care Hospital of Southern India
Authors: Banerjee Bidisha , Prabhu Sameeta M. , Lagudu Gowthami , Shetty Mitesh , Hegde Sridevi 
Published: November 2022

Abstract
Objective Dravet syndrome (DS) is an epileptic syndrome that shares similarities with febrile seizures (FS), especially before 1 year of age, making it challenging to differentiate the two. We describe the profile of DS, with emphasis on the first year of life that can aid in early diagnosis.
Methods The clinical, investigative, treatment, and outcome profiles of DS patients presenting to the outpatient department (OPD) between October 2016 and December 2021 in a single tertiary care center in South India were analyzed.
Results Seventeen children were studied, with median age at presentation of 30 (interquartile range [IQR] 10, 47) months. The median age at seizure onset was 5 (IQR 3, 6) months. First seizure semiology were generalized tonic-clonic (GTCS) (35.3%), focal (52.9%), and myoclonic (11.8%). Fever preceding first seizure was seen in 76.5%. Status epilepticus (SE; ≥30 minutes) and prolonged seizures (>10 minutes) were seen in 41.2% each, and >5 seizures were seen in 82.4% in the first year of life. The most frequent subsequent seizure types were focal seizures (76.5%) and GTCS (76.5%). Other seizure triggers included vaccination (52.9%), light (17.6%), and Hot-bath (5.8%). Delayed developmental milestones for age were found in 52.9% at diagnosis. Magnetic resonance imaging (MRI) brain and electroencephalogram were normal in 76.4% each. Pathogenic/likely pathogenic variants in SCN1A gene were seen in 64.7%. Average of 3.9 anti-seizure medications were used. After optimization of treatment seizure frequency reduced in 40% and 4/15 (26.6%) had SE.
Conclusion In addition to characteristic clinical profile of DS we observed atypical presentations: an earlier age of seizure onset and afebrile seizure at onset. Delayed diagnosis was noted. Seizure control improved and SE reduced on optimal treatment.
Language, translocality and urban change
Authors: Rosendal Tove , Nielsen Helle Lykke , Järlehed Johan , Milani Tommaso M. , Löfdahl Maria 
Published: November 2022

Abstract
This article addresses the role of translocal interconnectedness between offline and online spaces by examining the varied
presence of language displays in such spaces. Quantitative findings on language presence in the offline public spaces of four Gothenburg
neighbourhoods are contrasted with the online presence found in three Swedish search portals, and the differences are interpreted in light
of the broader socioeconomic processes of gentrification and segregation. The comparison between online and offline presence allows us to
give a more holistic picture of the neighbourhoods; it reveals, among other things, the presence of semi-public spaces, with a multilingual
presence of commercial enterprises and civil society organizations, and points out that some super-diverse neighbourhoods have more online
than offline presence on search portals. Thus, the often-stereotyped mental picture of these neighbourhoods as being passive, static,
‘segregated’ and ‘problematic’ is challenged.
The nature of graphs and graphemes in Middle Dutch writing and the problem of parsing
Authors: Wulf Chris De 
Published: November 2022

Abstract
This article focuses on the practical problems that go along with the sequencing of older non-standardised spelling forms into consonant and vowel graphemes. The issue of segmental parsing is important in research on the development of Dutch spelling, mostly drawing from thirteenth and fourteenth century charter spellings. The research aims are introduced in part 1, and then the problems of defining graphs and then syllables are discussed in part 2. These problems stem from the theoretical graphemic level, but have a very direct impact on the practical level, as they hinder the automatic parsing of tokens in the corpus, as discussed in part 3. The goal of this article is to provide partial solutions in parsing of non-standardised language data for graphemic research.
Two different experiments with the rope-attached sphere by using Arduino
Authors: Çoban Atakan , Akat Ercüment , Erdoğan Ahmet Cem 
Published: November 2022

Abstract
Arduino microcontrollers are electronic devices that can be used in physics experiments, and they are both affordable and readily available in comparison to other experimental sets. Students in high school and college can acquire valuable skills through the usage of Arduino in science, technology, engineering, and math (STEM) education applications. In this study, two different physics experiments were conducted with a single, easy to develop, experimental setup by using Arduino, a force sensor and a rope-attached metallic sphere. First experiment, involved several analyses such as period, rope tension, and energy conservation during simple harmonic motion. In the second experiment, the metal ball was released from the rope’s connecting point, and the impulse acting on it between the times it was released and when it returned to equilibrium was measured. Analyses performed are in very precise force and time intervals and the results of all analyses are consistent with the theoretical values. Educational activities in this direction can both create maximum gains for students in STEM fields in limited education periods and contribute to equality of opportunity in education due to its economic nature.
Incorporating cross-voxel exchange for the analysis of dynamic contrast-enhanced imaging data: pre-clinical results
Authors: Sinno Noha , Taylor Edward , Hompland Tord , Milosevic Michael , Jaffray David A , Coolens Catherine 
Published: November 2022

Abstract
Tumours exhibit abnormal interstitial structures and vasculature function often leading to impaired and heterogeneous drug delivery. The disproportionate spatial accumulation of a drug in the interstitium is determined by several microenvironmental properties (blood vessel distribution and permeability, gradients in the interstitial fluid pressure). Predictions of tumour perfusion are key determinants of drug delivery and responsiveness to therapy. Pharmacokinetic models allow for the quantification of tracer perfusion based on contrast enhancement measured with non-invasive imaging techniques. An advanced cross-voxel exchange model (CVXM) was recently developed to provide a comprehensive description of tracer extravasation as well as advection and diffusion based on cross-voxel tracer kinetics (Sinno et al 2021). Transport parameters were derived from DCE-MRI of twenty TS-415 human cervical carcinoma xenografts by using CVXM. Tracer velocity flows were measured at the tumour periphery (mean 1.78–5.82 μm.s−1) pushing the contrast outward towards normal tissue. These elevated velocity measures and extravasation rates explain the heterogeneous distribution of tracer across the tumour and its accumulation at the periphery. Significant values for diffusivity were deduced across the tumours (mean 152–499 μm2.s−1). CVXM resulted in generally smaller values for the extravasation parameter

K

e
x
t

(mean 0.01–0.04 min−1) and extravascular extracellular volume fraction

v

e

(mean 0.05–0.17) compared to the standard Tofts parameters, suggesting that Toft model underestimates the effects of inter-voxel exchange. The ratio of Tofts’ extravasation parameters over CVXM’s was significantly positively correlated to the cross-voxel diffusivity (P < 0.0001) and velocity (P = 0.0005). Tofts’ increased

v

e

measurements were explained using Sinno et al (2021)’s theoretical work. Finally, a scan time of 15 min renders informative estimations of the transport parameters. However, a duration as low as 7.5 min is acceptable to recognize the spatial variation of transport parameters. The results demonstrate the potential of utilizing CVXM for determining metrics characterizing the exchange of tracer between the vasculature and the tumour tissue. Like for many earlier models, additional work is strongly recommended, in terms of validation, to develop more confidence in the results, motivating future laboratory work in this regard.