bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved selection of extremely red quasars with boxy C iv lines in BOSS
Authors: Monadi Reza , Bird Simeon 
Published: February 2022

ABSTRACT
Extremely red quasars (ERQs) are an interesting sample of quasars in the Baryon Oscillation Spectroscopic Sample (BOSS) in the redshift range of 2.0–3.4 and have extreme red colours of i − W3 ≥ 4.6. Core ERQs have strong C  iv emission lines with rest equivalent width of ≥100 Å. Many core ERQs also have C  iv line profiles with peculiar boxy shapes which distinguish them from normal blue quasars. We show, using a combination of kernel density estimation and local outlier factor analyses on a space of the i − W3 colour, C iv rest equivalent width and line kurtosis, that core ERQs likely represent a separate population rather than a smooth transition between normal blue quasars and the quasars in the tail of the colour-REW distribution. We apply our analyses to find new criteria for selecting ERQs in this 3D parameter space. Our final selection produces 133 quasars, which are three times more likely to have a visually verified C iv broad absorption line feature than the previous core ERQ sample. We further show that our newly selected sample are extreme objects in the intersection of the WISE AGN catalogue with the MILLIQUAS quasar catalogue in the colour–colour space of (W1 − W2, W2 − W3). This paper validates an improved selection method for red quasars which can be applied to future data sets such as the quasar catalogue from the Dark Energy Spectroscopic Instrument.
Dirty waveforms: multiband harmonic content of gas-embedded gravitational wave sources
Authors: Zwick Lorenz , Derdzinski Andrea , Garg Mudit , Capelo Pedro R , Mayer Lucio 
Published: February 2022

ABSTRACTWe analyse the effect of stochastic torque fluctuations on the orbital evolution and the gravitational wave (GW) emission of gas-embedded sources with intermediate and extreme mass ratios. We show that gas-driven fluctuations imprint additional harmonic content in the GWs of the binary system, which we dub dirty waveforms (DWs). We find three interesting observational prospects for DWs, provided that torque fluctuations do indeed persist beyond the resolution limit of current hydrodynamical simulations. First, DWs can produce a significant stochastic GW background, comparable to other GW noise sources. Secondly, the energy flux implied by the additional harmonics can cause a detectable secular phase shift in Laser Interferometer Space Antenna (LISA) sources, even if the net torque fluctuations vanish when averaged over orbital time-scales. Lastly, the DWs of moderate-redshift nHz supermassive binaries detectable by pulsar timing arrays (PTAs) could be detectable in the mHz range, producing a new type of PTA–LISA multiband gravitational source. Our results suggest that searching for DWs and their effects can potentially be a novel way to probe the heaviest of black holes and the physics of the accretion discs surrounding them. We find these results to be a further confirmation of the many exciting prospects of actively searching for environmental effects within the data stream of future GW detectors.
Dietary magnesium supplementation inhibits abdominal vascular calcification in an experimental animal model of chronic kidney disease
Authors: Leenders Nicoline H J , Bos Caro , Hoekstra Tiny , Schurgers Leon J , Vervloet Marc G , Hoenderop Joost G J 
Published: February 2022

ABSTRACT

Background
Vascular calcification is a key process involved in cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD). Magnesium supplementation may counteract vascular calcification. In this study we aimed to determine whether increased dietary magnesium intake inhibits vascular calcification in CKD in vivo and explore the mechanisms underlying these effects.

Methods
Sprague Dawley rats were partially nephrectomized and fed a diet with high phosphate and either high or normal magnesium content for 16 weeks. The primary outcome was the tissue calcium content of the aorta in the high versus normal dietary magnesium group. In addition, we analysed plasma mineral concentrations, aortic vascular calcification identified with von Kossa staining, calcium apposition time and aortic expression of genes related to vascular calcification.

Results
The number of animals in the highest tissue calcium content tertile was significantly lower in the abdominal aorta [1 (10%) versus 6 (55%); P = .03] in the high versus normal dietary magnesium group, but did not differ in the aortic arch and thoracic aorta. Von Kossa staining and calcium apposition time corresponded to these results. The median tissue calcium content was not significantly different between the groups. Serum phosphate concentrations and expression of osteogenic markers in the aorta did not differ between the groups.

Conclusions
This study demonstrates that increased dietary magnesium inhibits abdominal vascular calcification in an experimental animal model of CKD in vivo. These are promising results for CKD patients and further study is needed to identify the mechanisms involved and to determine the clinical relevance in patients.
Plankton community response to fronts: winners and losers
Authors: Mangolte Inès , Lévy Marina , Dutkiewicz Stephanie , Clayton Sophie , Jahn Oliver 
Published: February 2022

AbstractFronts are particularly productive regions of the ocean, and biodiversity hotspots for many marine species. Here we use an ocean-ecosystem model to investigate the effect of fronts on plankton ecology. We focus on energetic fronts in Western Boundary Current systems that efficiently inject nutrients into the euphotic layer and which are physical boundaries between productive and oligotrophic provinces. We found that the fronts form an environment distinct from both provinces, favorable to some plankton groups (diatoms, dinoflagellates and large carnivorous zooplankton) and less favorable to others (pico-phytoplankton, coccolithophores and small grazers), and with an overall larger diversity. In agreement with previous understanding, we find that bottom-up abiotic processes (nutrient enrichment) explain the prevalence of groups with fast growing rates (the “winners”). Importantly, our results also show that biotic interactions within the ecosystem may play a larger role than previously thought. We show that the winners can have a negative impact on other plankton species (the “losers”) through two indirect competitive processes: community shading (modification of the light environment by the plankton community leading to light-limitation of some plankton groups) and shared predation (where an increase in one functional group leads to increased grazing by a shared predator on another functional group).
Mutual Fund Liquidity Transformation and Reverse Flight to Liquidity
Authors: Ma Yiming , Xiao Kairong , Zeng Yao 
Published: February 2022

Abstract
We identify fixed-income mutual funds as an important contributor to the unusually high selling pressure in liquid asset markets during the COVID-19 crisis. We show that mutual funds experienced pronounced investor outflows amplified by their liquidity transformation. In meeting redemptions, funds followed a pecking order by first selling their liquid assets, including Treasuries and high-quality corporate bonds, which generated the most concentrated selling pressure in these markets. Overall, the estimated price impact of mutual funds was sizable at a third of the increase in Treasury yields and a quarter of the increase in corporate bond yields during the COVID-19 crisis.
Predictors of rituximab effect on modified Rodnan skin score in systemic sclerosis: a machine-learning analysis of the DesiReS trial
Authors: Ebata Satoshi , Oba Koji , Kashiwabara Kosuke , Ueda Keiko , Uemura Yukari , Watadani Takeyuki , Fukasawa Takemichi , Miura Shunsuke , Yoshizaki-Ogawa Asako , Yoshihide Asano , Yoshizaki Ayumi , Sato Shinichi 
Published: February 2022

Abstract

Objectives
The double-blind, parallel-group comparison, investigators initiated phase II clinical trial of IDEC-C2B8 (Rituximab) in patients with Systemic sclerosis (DesiReS) trial showed that rituximab is effective in treating skin sclerosis in SSc. However, which patient groups are likely to benefit from rituximab is unknown.

Methods
We performed post-hoc analysis of prospective data from 54 patients who received rituximab or placebo in the DesiReS trial. Twenty-seven baseline factors were used to investigate subpopulations with different magnitudes of rituximab effect on modified Rodnan skin score (mRSS) change at 24 weeks. Based on a machine-learning algorithm called the causal tree, we explored the combination of predictors needed to identify subpopulations that would respond to rituximab and have good treatment outcomes.

Results
Three factors were identified as branches of the decision tree: peripheral blood CD19-positive cell counts’, ‘mRSS’, and ‘serum surfactant protein D (SP-D) levels’. It was only in the subpopulation of patients with CD19-positive cell counts of &lt;57/μl that rituximab did not show a significant improvement in mRSS vs placebo. In the subpopulation of patients with CD19-positive cell counts of ≥57/μl and mRSS ≥ 17, mRSS was most improved with rituximab [difference −17.06 (95% CI: −24.22, −9.89)]. The second greatest improvement in mRSS with rituximab was in the subpopulation with CD19-positive cell counts of ≥57/μl, mRSS &lt; 17, and serum SP-D levels of ≥151 ng/ml [difference −10.35 (95% CI: −14.77, −5.93)].

Conclusion
SSc patients who have high CD19-positive cell counts and high mRSS are expected to have greater improvement in mRSS with rituximab. When the patients with high CD19-positive cell counts show low mRSS, serum SP-D levels may modify the treatment effect.

Trial registration
ClinicalTrials.gov, https://clinicaltrials.gov, NCT04274257 and UMIN-CTR; https://center6.umin.ac.jp, UMIN000030139.
The school that moved: when does land cease to be used for charitable purposes?
Authors: Fry Rebecca 
Published: February 2022

Abstract
In Rittson-Thomas v Oxfordshire County Council [2021] UKSC 13 the Supreme Court held that school sites conveyed under the School Sites Act 1841 can be sold with vacant possession, provided the trustees have a clear intention to use the sale proceeds to buy or improve replacement school premises. The Court’s “broad and practical” approach maximises flexibility for local authorities and other school site trustees, while its finding that the balance struck by the Act leans in favour of public rather than private interests has wider implications for the construction of charitable trusts.
Whole blood use in trauma resuscitation: targeting prehospital transfusion
Authors: Rangrass Govind 
Published: February 2022

Purpose of review
Trauma resuscitation management has evolved over the years with a more nuanced understanding of the injured patient's physiologic state of shock. The purpose of this review is to discuss the role of whole blood administration in the prehospital setting in the resuscitation of the trauma patient.

Recent findings
In traumatically injured patients, whole blood administration initiated in the prehospital setting may improve early shock severity, coagulopathy, and survival when used over traditional resuscitation fluids such as crystalloid administration or component therapy.

Summary
The timing of resuscitation and its components deserve special attention when improving outcomes for trauma patients requiring massive transfusion.
Airway management in the critically ill patient with COVID-19
Authors: De Jong Audrey , Khanna Ashish K. 
Published: February 2022

Purpose of review
Critically ill Coronavirus disease 2019 (COVID-19) patients needing endotracheal intubation are on the verge of rapid decompensation. The aims of this review were to assess the risks, the preoxygenation, the device and the hemodynamic management of a patient with COVID-19.

Recent findings
The proceduralist performing endotracheal intubation with the entire team are at an increased risk for exposure to COVID-19. Appropriate personal protective equipment and other measures remain essential. For preoxygenation, noninvasive ventilation allows higher oxygen saturation during intubation in severely hypoxemic patients and can be associated with apneic oxygenation and mask ventilation during apnea in selected cases. The COVID-19 pandemic has further highlighted the place of videolaryngoscopy during intubation in intensive care unit (ICU). Hemodynamic optimization is mandatory to limit hypotension and cardiac arrest associated with airway management.

Summary
Future trials will better define the role of videolaryngoscopy, apneic oxygenation and mask ventilation during apnea for intubation of COVID-19 patients in ICU. The use of fluid loading and vasopressors remains to be investigated in large randomized controlled studies. Choosing the right time for intubation remains uncertain in clinical practice, and future works will probably help to identify earlier the patients who will need intubation.
Perioperative acute kidney injury: impact and recent update
Authors: Ojo Bukola , Campbell Cedric H. 
Published: February 2022

Purpose of review
Acute kidney injury (AKI) is common in hospitalized patients and is a major risk factor for increased length of stay, morbidity, and mortality in postoperative patients. There are multiple barriers to reducing perioperative AKI – the etiology is multi-factorial and the diagnosis is fraught with issues. We review the recent literature on perioperative AKI and some considerations for anesthesiologists that examine the far-reaching effects of AKI on multiple organ systems.

Recent findings
This review will discuss recent literature that addresses the epidemiology, use of novel biomarkers in risk stratification, and therapeutic modalities for AKI in burn, pediatrics, sepsis, trauma, cardiac, and liver disease, contrast-induced AKI, as well as the evidence assessing goal-directed fluid therapy.

Summary
Recent studies address the use of risk stratification models and biomarkers, more sensitive than creatinine, in the preoperative identification of patients at risk for AKI. Although exciting, these scores and models need validation. There is a need for research assessing whether early AKI detection improves outcomes. Enhanced recovery after surgery utilizing goal-directed fluid therapy has not been shown to make an appreciable difference in the incidence of AKI. Reducing perioperative AKI requires a multi-pronged and possibly disease-specific approach.
Pedicle Subtraction Osteotomy Construct Optimization
Authors: Pereira Bernardo de Andrada , Godzik Jakub , Lehrman Jennifer N. , Sawa Anna G.U. , Hlubek Randall J. , Uribe Juan S. , Kelly Brian P. , Turner Jay D. 
Published: February 2022

Study Design.
Fourteen cadaveric specimens were separated into two groups: (1) L3 pedicle subtraction osteotomy (PSO) with transforaminal lumbar interbody fusion (TLIF) or (2) lateral lumbar interbody fusion (LLIF). A 2-rod configuration (2R) was compared with two supplemental rod configurations: 4-rod (4R) with accessory rods (ARs) using connectors or 4R with satellite rods (SRs) without connectors.

Objective.
Compare PSO constructs with different rod configurations and adjacent-level interbody support.

Summary of Background Data.
Supplemental rods and anterior column support enhance biomechanical performance.

Methods.
Pure moments were applied in (1) intact, (2) pedicle screws and rods, (3) PSO + 2R, (4) 4R AR, and (5) 4R SR conditions. Primary and supplemental rods had strain gauges across the index level. Sacral screw bending moments and range of motion (ROM) were recorded.

Results.
For TLIF, AR decreased ROM during flexion (P = 0.02) and extension (P < 0.001) versus 2R. For LLIF, AR and SR decreased motion versus 2R during left (AR: P
= 0.03; SR: P
= 0.04) and right (AR: P
= 0.002; SR: P
= 0.01) axial rotation. For LLIF, sacral screw strain increased with SR compared with AR in compression and right lateral bending (P ≤ 0.03). During lateral bending, rod strain increased with PSO+TLIF+SR versus PSO+LLIF+2R and PSO+LLIF+AR (P ≤ 0.02). For LLIF, SR configuration increased rod strain versus AR during flexion, extension, and lateral bending (P≤ 0.01); for TLIF, rod strain increased with SR versus AR during extension (P = 0.03). For LLIF, AR configuration increased posterior supplemental rod strain versus SR during flexion (P = 0.02) and lateral bending (P < 0.001).

Conclusion.
Both supplemental rod configurations reduced motion in both groups. Constructs with the SR configuration increased the primary rod strain and the sacral screw bending moment compared with AR constructs, which can share strain. Deep-seated SRs, which have become increasingly popular, may be more vulnerable to failure than ARs. LLIF provided more stability in sagittal plane. Protective effect of supplemental rods on rod strain was more effective with TLIF.

Level of Evidence: NA
The Effect of Melatonin on Radicular Pain in a Rat Model of Lumbar Disc Herniation
Authors: Tang Qian , Huang YangLiang , Zhu LiRong , Zhang WeiLi , Zhao YuanShu , Zhong Yi 
Published: February 2022

Study Design.
Controlled, randomized, animal study.

Objective.
To investigate the effect of melatonin and its receptors on radicular pain and the possible mechanisms.

Summary of Background Data.
Lumbar disc herniation (LDH) may induce radicular pain, but the mechanism is not clear and therapeutic effect is still poor. Previously we report central sensitization meaning potentiation of spinal nociceptive synaptic transmission is the critical cause of radicular pain. Melatonin (Mel) has been reported to promote hippocampal synaptic transmission and thus improve learning ability. But the effect of Mel on spinal synaptic transmission and radicular pain are not clear.

Methods.
Rat LDH model was induced by autologous nucleus pulposus (NP) implantation. Melatonin was delivered intraperitoneally four times a day, from day 1 to day 3 after surgery. Melatonin receptor agonist and antagonists were delivered intrathecally for 3 days as well. Mechanical and thermal pain thresholds were assessed by von Frey filaments and hotplate test respectively. Electrophysiological recording was employed for survey C-fiber evoked field potentials. The protein level of N- methyl-D-aspartate submit 2A (NR2A), NR2B, melatonin receptor 1 (MT1), and receptor 2 (MT2) was evaluated by western blotting. Spinal expression of calcitonin gene related peptides (CGRP), isolectin b4 (IB4), and neurofilament-200 (NF200) was displayed by immunofluorescence staining.

Results.
Melatonin significantly increased mechanical and thermal pain thresholds, lasting at least to day 5 after surgery. Melatonin decreased C-fiber evoked field potentials; decreased spinal NR2B protein level; reduced spinal CGRP, and IB4 expression. MT2 was upregulated after NP implantation and was co-localized with neuron and microglia. MT2 receptor agonist simulated the effect of Mel, and both MT receptor broadspectrum antagonist and MT2 specific antagonist abolished the effect of MT2 receptor agonist.

Conclusion.
Melatonin alleviates radicular pain from LDH by inhibiting central sensitization via binding with its receptor 2, decreasing spinal CGRP, IB4, and NR2B expression.
Electrical Stimulation-Mediated Tissue Healing in Porcine Intervertebral Disc Under Mechanically Dynamic Organ Culture Conditions
Authors: Kanan Mohamad , Eby Oliver , Kelkar Amey , Serhan Hassan , Zodak Yehuda , Aldoohan Sulaiman , Elsamaloty Haitham , Goel Vijay , Yildirim-Ayan Eda 
Published: February 2022

Study Design.
Porcine intervertebral discs (IVDs) were excised and then drilled to simulate degeneration before being electrically stimulated for 21 days while undergoing mechanical loading. The discs were then analyzed for gene expression and morphology to assess regeneration.

Objective.
The purpose of this study was to investigate the effectiveness of the electrical stimulation of IVD treatment as an early intervention method in halting the progression of degenerative disc disease using an ex-vivo porcine model.

Summary of Background Data.
Treatments for degenerative disc disease are limited in their efficacy and tend to treat the symptoms of the disease rather than repairing the degenerated disc itself. There is a dire need for an early intervention treatment that not only halts the progression of the disease but contributes to reviving the degenerated disc.

Methods.
Lumbar IVDs were extracted from a mature pig within 1 hour of death and were drilled with a 1.5 mm bit to simulate degenerative disc disease. Four IVDs at a time were then cultured in a dynamic bioreactor system under mechanical loading for 21 days, two with and two without the electrical stimulation treatment. The IVDs were assessed using histological analysis, magnetic resonance imaging, and quantitative reverse transcriptase polymerase chain reaction to quantify the effectiveness of the treatment on the degenerated discs.

Results.
IVDs with electrical stimulation treatment exhibited extensive annular regeneration and prevented herniation of the nucleus pulposus (NP). In contrast, the untreated group of IVDs were unable to maintain tissue integrity and exhibited NP herniation through multiple layers of the annulus fibrosus. Gene expression showed an increase of extracellular matrix markers and antiinflammatory cytokine interleukin-4 (IL-4), while decreasing in pro-inflammatory markers and pain markers in electrically stimulated IVDs when compared to the untreated group.

Conclusion.
The direct electrical stimulation application in NP of damaged IVDs can be a viable option to regenerate damaged NP and annulus fibrosus tissues.
Comparison in the development of colorectal cancer after screening colonoscopy between elderly and younger population
Authors: Yamamoto Kazuki , Ikeya Takashi , Fukuda Katsuyuki , Kobayashi Daiki 
Published: February 2022

Background and aims
This study aimed to evaluate and compare the incidence of colorectal cancer (CRC) in elderly participants aged ≥75 years and those <75 years who had previously undergone a colonoscopy.

Methods
This retrospective cohort study was conducted at the Center for Preventive Medicine at St. Luke’s International Hospital in Japan. All participants who underwent screening colonoscopy between 2005 and 2015 were included and followed up until 2020. Our primary outcome was the identification of CRC as confirmed by pathology after screening colonoscopy. We compared the development of CRC between the two groups using survival analyses. A sub-analysis to evaluate the incidence of CRC among participants with and without neoplastic polyp resection at initial colonoscopy was also performed.

Results
A total of 8350 participants were enrolled; the median follow-up period was 2982 days (interquartile range:1932–4141), mean age was 52.5 years (SD: 11.5) and 5274 (61.3%) participants were men. The incidence of CRC during the follow-up period was 82 (0.95%) among all participants and 11 (4.31%) among the elderly participants. Elderly participants showed a significantly higher incidence of CRC than the other group [hazard ratio, 2.56; 95% confidence interval (CI), 1.14–5.75]. The sub-analysis showed that out of 2878 participants with a neoplastic polyp at the initial colonoscopy, 52 (1.81%) developed CRC (hazard ratio, 2.85; 95% CI, 1.16–6.98).

Conclusions
A repeat colonoscopy might be warranted in people with high activities of daily living and few comorbidities, especially if there is a history of neoplastic polypectomy at the first colonoscopy.