bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac sarcoidosis and giant cell myocarditis after COVID‐19 infection
Authors: Bollano Entela , Polte Christian Lars , Mäyränpää Mikko I. , Oldfors Anders , Bergh Niklas , Lehtonen Jukka , Kandolin Riina 
Published: August 2022

AbstractPatients infected with SARS‐CoV‐2 have varying manifestations of cardiac involvement. We report four patients presenting with symptomatic cardiac sarcoidosis (CS) or giant cell myocarditis (GCM) 1–8 months after mild COVID‐19. All patients received immunosuppressive therapy and improved gradually within the following months. The possible temporal association between the CS/GCM and COVID‐19 infection might suggest that COVID‐19 could be a trigger for granulomatous myocarditis.
Ligand Exchange Triggered Photosensitizers – Bodipy‐Tagged NHC‐Metal Complexes for Conversion of 3O2 to 1O2
Authors: Popov Stepan , Plenio Herbert 
Published: August 2022

AbstractA new imidazolium salt 3⋅HI with 8‐Bodipy as one N‐aryl substituent was synthesized from 8‐chloro‐Bodipy and imidazole followed by alkylation with iPrI. NHC‐metal complexes [CuCl(3)], [AuCl(3)], [Pd(allyl)Cl(3)] and [MCl(cod)(3)] and [MCl(CO)2(3)] (M=Rh, Ir) were synthesized and the X‐ray crystal structure of [IrCl(CO)2(3)] determined. The donation of NHC 3 was determined via IR (ν(CO) and cyclic voltammetry (Ir(I/II) redox potential). The photosensitizing properties of the complexes for the generation of 1O2 were quantified observing singlet oxygen quantum yield of up to Φs.o.=0.63. [IrCl(cod)(3)] displays poor Φs.o.=0.09, but, following a simple ligand exchange reaction of cod by two CO [IrCl(CO)2(3)], a pronounced increase to Φs.o.=0.63 is observed.
A review of healthy aging in China, 2000–2019
Authors: Zhao Litao 
Published: August 2022

AbstractIn 2021, China became an aged society when the share of its elderly population (age 65 years and above) exceeded 14%. In China, as in other upper‐middle‐income and high‐income countries, life expectancy gains are increasingly concentrated at older ages with below‐average health and economic activity. Governments worldwide are hence actively pursuing healthy and productive aging. Healthy aging by some measures is taking place. Similar with other upper‐middle‐income countries, China's young old in their 60s are healthier than the same age group two decades ago. The picture is more complex for the older age group (70 years and above). Although there is a substantial decline in leading disease burdens such as stroke and chronic obstructive pulmonary disease, diseases such as Alzheimer's and other dementia are on the rise. To meet the challenge of a rapidly aging population, China's healthy aging agenda should improve its multipronged approach that seeks to promote healthy lifestyles, enhance the healthcare system, create age‐friendly communities, and tackle socioeconomic and health disparities.
Granulocyte colony‐stimulating factor attenuates liver damage by M2 macrophage polarization and hepatocyte proliferation in alcoholic hepatitis in mice
Authors: Cho Yeonhee , Joshi Radhika , Lowe Patrick , Copeland Christopher , Ribeiro Marcelle , Morel Caroline , Catalano Donna , Szabo Gyongyi 
Published: August 2022

Abstract
Massive inflammation and liver failure are main contributors to the high mortality in alcohol‐associated hepatitis (AH). In recent clinical trials, granulocyte colony‐stimulating factor (G‐CSF) therapy improved liver function and survival in patients with AH. However, the mechanisms of G‐CSF‐mediated beneficial effects in AH remain elusive. In this study, we evaluated effects of in vivo G‐CSF administration, using a mouse model of AH. G‐CSF treatment significantly reduced liver damage in alcohol‐fed mice even though it increased the numbers of liver‐infiltrating immune cells, including neutrophils and inflammatory monocytes. Moreover, G‐CSF promoted macrophage polarization toward an M2‐like phenotype and increased hepatocyte proliferation, which was indicated by an increased Ki67‐positive signal colocalized with hepatocyte nuclear factor 4 alpha (HNF‐4α) and cyclin D1 expression in hepatocytes. We found that G‐CSF increased G‐CSF receptor expression and resulted in reduced levels of phosphorylated β‐catenin in hepatocytes. In the presence of an additional pathogen‐associated molecule, lipopolysaccharide (LPS), which is significantly increased in the circulation and liver of patients with AH, the G‐CSF‐induced hepatoprotective effects were abolished in alcohol‐fed mice. We still observed increased Ki67‐positive signals in alcohol‐fed mice following G‐CSF treatment; however, Ki67 and HNF‐4α did not colocalize in LPS‐challenged mice. Conclusion: G‐CSF treatment increases immune cell populations, particularly neutrophil counts, and promotes M2‐like macrophage differentiation in the liver. More importantly, G‐CSF treatment reduces alcohol‐induced liver injury and promotes hepatocyte proliferation in alcohol‐fed mice. These data provide new insights into the understanding of mechanisms mediated by G‐CSF and its therapeutic effects in AH.
The future risk of primary biliary cholangitis (PBC) is low among patients with incidental anti‐mitochondrial antibodies but without baseline PBC
Authors: Duan Weijia , Chen Sha , Li Shuxiang , Lv Tingting , Li Buer , Wang Xiaoming , Wang Yu , Zhao Xinyan , Ma Hong , Ou Xiaojuan , You Hong , Jia Jidong 
Published: August 2022

Abstract
Anti‐mitochondrial autoantibodies (AMAs) are highly specific for the diagnosis of primary biliary cholangitis (PBC) but are also occasionally found in other diseases. In the present study, we evaluated the incidence of and predictors for PBC development in AMA‐positive patients with other liver or non‐liver diseases at baseline. In this retrospective study, we screened patients who tested positive for AMA and/or anti‐mitochondrial M2 antibody (AMA‐M2) at Beijing Friendship Hospital, Capital Medical University, from October 2005 to January 2017. They were categorized by their diagnosis at the baseline as patients with PBC or non‐PBC cases. We followed up on the non‐PBC cases through telephone interviews and reviewing of medical records to obtain laboratory results and clinical outcomes. In total, 139 patients were AMA‐positive but did not fulfill the diagnostic criteria of PBC at baseline, including 51 patients with non‐PBC liver diseases and 88 cases with non‐liver diseases. The titers of AMA‐M2, alkaline phosphatase, gamma‐glutamyl transpeptidase, and immunoglobulin M were significantly higher in patients with PBC compared to those with non‐PBC liver diseases and non‐liver diseases. After a median follow‐up of 4.6 (interquartile range: 2.4–7.6) years, 4.3% (6 of 139) developed PBC, with an accumulative 5‐year incidence rate of 4.2%. None of the patients with non‐PBC liver diseases developed PBC, whereas the 5‐year incidence rate of PBC was 7.8% among 88 patients with non‐liver diseases. Lower alanine aminotransferase and higher immunoglobulin M were independent predictors for developing PBC. Conclusion: Our results suggest a low risk of developing PBC over time in AMA‐positive patients with other liver and non‐liver diseases.
Arousing employee pro‐environmental behavior: A synergy effect of environmentally specific transformational leadership and green human resource management
Authors: Tu Yu , Li Yiqiong , Zuo Wenchao 
Published: August 2022

AbstractEmployee proactive pro‐environmental behavior (PEB) has been increasingly emphasized as an essential behavior benefiting the environment and organizational sustainability. Nevertheless, both scholars and practitioners need a fuller yet nuanced understanding of the antecedents and boundary condition of PEB. Drawing from theories of cue consistency and proactivity, we advance an interaction perspective to explain how environmentally specific transformational leadership (ESTL) as guidance and green human resource management (GHRM) as normative practices interact to arouse employee PEB and how three fine‐grained proactive psychological states of green self‐efficacy, environmental self‐accountability, and environmental passion transmit these effects. Two lab experiments constructively offered causal support for our main hypotheses, and a multilevel, multiphase, and multisource field study verified our integrative model and enhanced the generalizability of conclusions. Results indicated that in addition to the direct positive effects, organization‐level GHRM, and individual‐level ESTL also showed a synergy effect in predicting employee PEB. Three differentiated proactive psychological states positively linked the underlying processes, especially in the high‐GHRM context. The findings highlight a multilevel antecedent framework of employee PEB and provide a useful attempt to answer the lingering debate about interactions between leadership and human resource management systems.
Joint calibration of S&P 500 and VIX options under local stochastic volatility models
Authors: Zhou Zhiqiang , Xu Wei , Rubtsov Alexey 
Published: August 2022

AbstractIt is extremely challenging to design a model calibrating both SPX and VIX option prices. A long‐standing conjecture due to Julien Guyon is that it may not be possible to calibrate these two quantities with a continuous model. So far, most studied continuous time models are affine, so we investigate the conjecture among 14 well‐known non‐affine local stochastic volatility models in this article. First, we propose a unified efficient willow tree method for S&P500 and VIX option pricing under non‐affine models. Second, we compare the joint calibration performance on these 14 models on the S&P500 and VIX option prices data from 2006 to 2019. We find that the VIX option price data can provide extra information of the variance dynamics of the models, and the non‐affine structure and the volatility with linear, rather than square‐root, diffusion process provide a better fit for the both data sets than the affine counterparts. Among the 14 stochastic models, the SABR model provides the best in‐ and out‐of‐sample performance (in terms of mean square error) regardless of the state of the economy. Nevertheless, even for the best‐fitted SABR model, the relative error on the VIX option is still around 18%, still quite significant. Therefore, we found the non‐affine and local volatility structure improve the joint calibration but are still far from satisfactory.
Will lithium‐sulfur batteries be the next beyond‐lithium ion batteries and even much better?
Authors: Sun Jianguo , Wang Tuo , Gao Yulin , Pan Zhenghui , Hu Runpeng , Wang John 
Published: August 2022

AbstractLithium‐ion batteries (LIBs) are undoubtedly the current working‐horse in almost all portable electronic devices, electric vehicles, and even large‐scale stationary energy storage. Given the problems faced by LIBs, a big question arises as to which battery(ies) would be the “Beyond LIBs” batteries. Among the front‐runners, lithium‐sulfur batteries (LSBs) have been extensively pursued owing to their intrinsically high energy density and extremely low cost. Despite the steady and sometimes exciting progress reported on sulfur chemistry and cell performance at laboratory scales over the past decade, one of the major bottlenecks is the poor cyclability. In this perspective, we examine the key challenges and opportunities faced by LSBs, as well as approaches at the materials, electrode/electrolyte and cell integration levels that can be taken to transform LSBs from a front‐runner to a real leading champion in the pursuit of the “Beyond LIBs”. While the key new mechanistic insights are very important, we propose a set of the near‐future research directions for both the liquid and solid state LSBs, where the currently on‐going parallel pursuits of both liquid and solid LSBs will be converging. The “liquid current” will gradually be taken over by “solid future” in the expected LSBs commercialization in the coming decade.image
Instrumental‐variable estimation of exponential‐regression models with two‐way fixed effects with an application to gravity equations
Authors: Jochmans Koen , Verardi Vincenzo 
Published: August 2022

SummaryThis paper introduces instrumental‐variable estimators for exponential‐regression models that feature two‐way fixed effects. These techniques allow us to develop a theory‐consistent approach to the estimation of cross‐sectional gravity equations that can accommodate the endogeneity of policy variables. We apply this approach to a dataset in which the policy decision of interest is the engagement in a free‐trade agreement. We explore ways to exploit the transitivity observed in the formation of trade agreements to construct instrumental variables with considerable predictive ability. Within a bilateral model, the use of these instruments has strong theoretical foundations. We obtain point estimates of the partial effect of a preferential‐trade agreement on trade volume that range between 20% and 30% and find no statistical evidence of endogeneity.
Can charcoal hemoperfusion treatment be an option for pediatric MIS‐C patients? A single‐center experience in a tertiary pediatric intensive care unit
Authors: Varol Fatih , Guney Sahin Ebru , Cengiz Mehmet , Kilic Aziz , Altas Zeynep Meva , Guven Sirin , Çam Halit 
Published: August 2022

AbstractIntroductionMultisystem inflammatory syndrome in children (MIS‐C) is a hyper‐inflammatory disorder that develops following SARS‐CoV‐2 infection and has clinical signs that overlap with Kawasaki disease. Immunomodulatory treatments can be used in these patients. One of the alternative treatments reported in the literature is hemoperfusion therapy. In this study, we aim to evaluate our experience of charcoal hemoperfusion therapy in children admitted and followed up with a diagnosis of MIS‐C at our Pediatric Intensive Care Unit (PICU).Material and MethodsWe performed a retrospective evaluation of children diagnosed with MIS‐C and children treated with charcoal hemoperfusion who are admitted to our PICU.ResultsAmong 49 MIS‐C patients, hemoperfusion therapy was performed on 14 patients. Duration of hospitalization, duration of invasive/non‐invasive ventilation, VIS, OFI, PRİSM 3 scores, and mortality rates were significantly higher in the charcoal hemoperfusion group before treatment. In patients who did not respond to conventional therapies, we observed a statistically significant decrease in the need for inotrope and invasive mechanical ventilation support and statistically significant improvements in clinical indicators after hemoperfusion therapy.DiscussionIn our study, we observed a significant clinical and laboratory improvement by charcoal hemoperfusion in our MIS‐C patients who had a severe clinical course and multiple organ failure.ConclusionIn our opinion, this study is the first report regarding the use of charcoal hemoperfusion therapy in MIS‐C patients, and the choice of charcoal hemoperfusion as an initial or rescue therapy is needed to be investigated in large patient groups both in children and adults who are diagnosed with COVID‐19 and MIS‐C.
Discovery of promising cholinesterase inhibitors for Alzheimer's disease treatment through DFT, docking, and molecular dynamics studies of eugenol derivatives
Authors: Nour Hassan , Abdou Achraf , Belaidi Salah , Jamal JamalEddine , Elmakssoudi Abdelhakim , Dakir Mohamed , Chtita Samir 
Published: August 2022

AbstractCholinesterase enzymes are promising drug targets for the symptomatic treatment of Alzheimer's disease. Indeed, the activity inhibition of these acetylcholine‐degrading enzymes leads to improved neurocognitive function. The present work, attempted to identify eugenol derivatives possibly capable of inhibiting the acetylcholine enzymes, by implementing density functional theory (DFT), docking and molecular dynamics methods. The investigated compounds exhibited moderate to high affinity toward the target proteins with free binding energy values ranging from −6.3 to −11.5 kcal/mol. The best ligands in terms of binding energy were evaluated for their pharmacokinetic properties. Furthermore, molecular dynamics studies were performed to assess the stability under aqueous environment of ligands having shown good pharmacokinetic properties. The obtained results revealed that 4‐alkyl‐2‐methoxyphenyl 3‐bromobenzoate strongly tended to act as dual inhibitor of Acetylcholinesterase and Butyrylcholinesterase, leading to a good alternative for the treatment of AD. The highlighting of this study can be of great support for the Alzheimer treatment development.
Impact of Multiple Concomitant CYP3A Inhibitors on Venetoclax Pharmacokinetics: A PBPK and Population PK‐Informed Analysis
Authors: Mukherjee Dwaipayan , Brackman Deanna J. , Suleiman Ahmed A. , Zha Jiuhong , Menon Rajeev M. , Salem Ahmed Hamed 
Published: August 2022

AbstractVenetoclax is an approved, orally bioavailable, B‐cell lymphoma type 2 (BCL‐2) inhibitor that is primarily metabolized by cytochrome P450 3A (CYP3A). Polypharmacy is common in patients undergoing treatment for hematological malignancies such as acute myeloid leukemia or chronic lymphocytic leukemia, and although venetoclax exposure has been well characterized with 1 concomitant CYP3A inhibitor, complex drug–drug interactions (DDIs) involving more than 1 inhibitor have not been systematically evaluated. Here, we aimed to describe the potential impact of multiple concomitant CYP3A inhibitors on venetoclax pharmacokinetics (PK) using physiologically based pharmacokinetic (PBPK) and population PK modeling. The modeling approaches were informed by clinical data in the presence of single or multiple CYP3A inhibitors, and the effects of 1 or more inhibitors were systematically considered within these modeling frameworks. The PBPK modeling approach was independently validated against clinical data involving more than 1 CYP3A inhibitor along with CYP3A substrates other than venetoclax. Both approaches indicated that combining a strong CYP3A inhibitor with another competitive CYP3A inhibitor does not seem to result in any additional increase in venetoclax exposure, beyond what would be expected with a strong inhibitor alone. This suggests that the current dose reductions recommended for venetoclax would be appropriate even when 2 or more CYP3A inhibitors are taken concomitantly. However, the results indicate that the involvement of time‐dependent inhibition might lead to additional inhibitory effects over and above the effect of a single strong CYP3A inhibitor. Thus, the clinical management of such interactions must consider the underlying mechanism of the interactions.
Sludge retention time effects on recovery of soluble organic matters via polyhydroxyalkanoate storage in contact stabilization process under feast/famine regime
Authors: Sun Feng‐Long , Cui You‐Wei , Jian Li , Yao Jia‐Lin 
Published: August 2022

AbstractBACKGROUNDContact stabilization (CS) can be used to capture organic matters from wastewater. However, CS is less efficient in capturing soluble organic matters (SOMs). Recovery of SOMs is required to minimize carbon emission and to maximize organic recovery from wastewater.RESULTSSOMs were recovered by applying a feast/famine (F/F) regime in a CS process. Sludge retention time (SRT) was found to regulate the recovery efficiency of SOMs. At a SRT of 4 d, 44.7% of the removed soluble chemical oxygen demand (SCOD) in wastewater was recovered and stored into intracellular polyhydroxyalkanoates (PHA), leading to 12.8% decrease of CO2 emission in comparison with the conventional activated sludge process. The storage of PHA in waste sludge harvested at a SRT of 4 d significantly increased the methane yield (187.3 ± 5.9 mL (g VSS)−1). The dominant bacteria performing SOM recovery in CS belonged to the genera Tessaracoccus, norank_f__Caldilineaceacea, unclassified_f__Microbacteriaceae and Flavobacterium.CONCLUSIONSThe study demonstrated that applying F/F regime in a CS process can recover SOMs via PHA storage. The regulation of SRT can enhance SCOD recovery. The study provides a solution to enhance SOM recovery from wastewater instead of being oxidized into CO2. © 2022 Society of Chemical Industry (SCI).Highlights
SCOD can be recovered via PHA by applying F/F regime in CS mode.
The optimum SRT of 4 d resulted 44.7% SCOD recovery via PHA storage.
PHA‐accumulating bacteria belonged to four genera.
Anaerobic digestion of sludge resulted in a 17.6% higher CH4 yield.
CO2 emission decreased 12.8% compared with conventional activated sludge process.
Storm types in Bangladesh: duration, intensity and area of intra‐daily wet events
Authors: Moron Vincent , Acharya Nachiketa , Hassan S. M. Quamrul 
Published: August 2022

AbstractWe explore the characteristics of 96,190 wet events (WEs) defined as consecutive 3‐hourly rainfall ≥ 1 mm/3 hr from a network of 34 stations across Bangladesh. Nearly 60% (5%) of WEs last ≤ 3 (≥ 15) hr. The WEs are dynamically clustered into four “canonical” storm types (STs), mostly discretized by their duration, but also their mean and maximal intensity. While durations, total amounts and wet contiguous areas of WEs are positively related, their mean intensity is nearly independent of them. Approximately 60% of WEs are associated with ST#1, characterized by short and small WEs and very low rainfall amounts (usually <10 mm), ~30% of WEs are associated with either (ST#2) short/small WEs but with intense rainfall, probably mostly related to scattered thunderstorms or (ST#3) longer/larger WEs but with less intense rainfall. The last ST (ST#4) is rare (~6%), related to very long durations and large wet areas and includes the wettest WEs. It is especially frequent over southeastern Bangladesh. ST#2–ST#4 contribute almost equally to the local‐scale total amount of rainfall (27–29% each in mean) while ST#1, despite its individual low rainfall amount, still includes ~15% of it. ST#2 (ST#4) is related to the highest probability of occurrence of 3‐hourly (daily) extremes. ST#4 occurrence is the most impacted by synoptic Indian lows/depressions as well as the main modes of intra‐seasonal variation, while ST#1 and ST#2 are also significantly impacted by intra‐seasonal modes but in reverse manner than ST#4.
Creativity Profiles and the Role of Interpersonal Relationships in Primary School Pupils: A Person‐Centered Approach
Authors: Liu Jiabin , Yu Linwei , Zhao Xiaoqian , Liu Yanan , Jiao Lan 
Published: August 2022

ABSTRACTThis study aimed to investigate the heterogeneity of creativity and the role of interpersonal relationships for creativity subgroups among primary school students. We used latent profile analysis to identify subgroups of creativity among pupils. We then used logistic regression analysis to investigate the role of teacher‐student and peer relationships in these subgroups. A total of 1,047 primary school students (Mage = 10.97, SD = 0.91; 47.80% girls) completed the Chinese version of the Torrance Test of Creative Thinking Figural Form A, the Teacher‐Student Relationship Scale, and peer nominations. First, the results revealed five creativity profiles for pupils in primary school: high‐creativity individuals, innovators, medium‐creativity individuals, adaptors, and low‐creativity individuals. Heterogeneity across the five subgroups was reflected in the differing creativity levels and differences in creativity dimensions. Second, students who had better teacher‐student relationships were more likely to be high‐creativity individuals and innovators than low‐creativity individuals. In addition, students who had higher perceived popularity tended to be high‐creativity individuals, innovators, adaptors, and medium‐creativity individuals than low‐creativity individuals. The results of this study provide a theoretical basis and empirical support for the targeted cultivation of creativity in primary schools.