bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive value of extubation failure diagnosed by decrease in central venous oxygen saturation: a systematic review and meta-analysis
Authors: Wu Chenxia , Hu Luoxia , Shen Qinkang , Xu Hua , Huang Haijun 
Published: May 2022

Abstract
Background: The predictive power of extubation failure diagnosed by decrease in central venous oxygen saturation(ΔScvO2) varies by studies. Here we summarized the diagnostic value of extubation failure tested by ΔScvO2.Methods: A comprehensive online search was performed to select potentially eligible studies that evaluated the predictive power of extubation failure tested by ΔScvO2. A manual search was also performed to identify additional studies. Data were extracted to calculate the pooled sensitivity, specificity, positive likelihood ratio (LR),negative LR, diagnostic odds ratio (DOR), and area under the receiver operating characteristic curve (AUC) to evaluate the predictive power of extubation failure.Results: Overall, five studies including 353 patients were included in this review, of whom 105 (30%) were extubation failure. The cutoff values of ΔScvO2 varied across studies, ranging from 3.8% to 5.4%. Heterogeneity between studies was assessed with an overall Q = 0.007, I2 = 0%, and P = 0.498. The pooled sensitivity and specificity for the overall population were 0.83 (95% CI: 0.74-0.90) and 0.88 (95% CI: 0.83-0.92), respectively. The pooled positive LR and negative LR were 7.2 (95%CI: 4.6-11.2) and 0.19 (95%CI: 0.12-0.31), respectively. The DOR was 38 (95% CI: 17–86). Overall, the pooled AUROC was 0.92 (95% CI: 0.90–0.94).Conclusions: The ΔScvO2 performed well in predicting extubation failure in adult mechanical ventilation patients.Further studies with a larger data set and well-designed models are required to confirm the diagnostic accuracy and utility of ScvO2 in predicting extubation outcomes in mechanical ventilation patients.
Calibrating a Three-Viewpoints Thermal Camera with Few Correspondences
Authors: Kim Ju O , Kim Jieun , Lee Deokwoo 
Published: May 2022

Abstract

This paper proposes the approach to calibration of a thermal camera that has three viewpoints. This work estimates the intrinsic parameters of the camera by establishing geometric relationship between real-world scene points and image points. This work estimates the extrinsic parameters , i.e., rotation and translation of the camera using vanishing points. The present work is different from the existed work on the calibration from three perspectives. The first one is that this work calibrates thermal camera with three viewpoints whose relative rotation is greater than 180-degree. The second one is that the viewpoints shares few overlapped areas due to the structure of the camera, so the proposed work is more challenging and difficult than the previous work on the calibration. The third one is that projected image of a scene requires quality enhancement for the calibration. Since few overlapped images are given a priori, feature matching cannot be used for the calibration. Instead of using correspondence matching, vanishing points are exploited to estimate relative rotations of cameras. The intrinsic parameters are estimated by capturing thermal-checkerboard followed by image processing. Experimental results show the accuracy and stability of the proposed approach for estimation of the intrinsic and the extrinsic parameters.
Shape-selective remobilization of microparticles in a mesh-based DEP filter at high throughput
Authors: Weirauch Laura , Giesler Jasper , Baune Michael , Pesch Georg R. , Thöming Jorg 
Published: May 2022

Abstract
In numerous of studies, dielectrophoresis (DEP) has proven that its high selectivity and versatility make it a promising separation technique in a variety of fields. So far, however, only a few processes in the bioanalytics have made it to commercial use. One of the main challenges is to achieve a technically relevant throughput while maintaining a high selectivity. We present a novel approach of a mesh-based DEP filter with ordered field disturbing structures that has a high potential for upscaling because low-cost and commercially available materials are used. In this filter, we firstly trap a mixture of particles and then selectively remobilize them via a frequency shift, which allows for multidimensional separation. Shape-selective separation is demonstrated using ellipsoidal and spherical polystyrene particles, first in established microchannels and subsequently in the mesh-based filter. Hence, particles were trapped at flow rates up to 120 mLh-1 and then selectively remobilized according to their shape. These results pave the way for high-throughput multitarget separations in a single and scalable device.
The Effects of flaxseed supplementation on circulating adipokines concentration in patients with ulcerative colitis
Authors: Morshedzadeh Nava , Rahimlou Mehran , Shahrokh Shabnam , Chaleshi Vahid , Mirmiran Parvin , Zali Mohammad Reza 
Published: May 2022

Abstract
Introduction: Inflammatory bowel disease (IBD) is one of the most common gastrointestinal diseases affecting people of all ages. Adipokines secreted from adipose tissue have been shown to play an essential role in the pathogenesis of ulcerative colitis (UC). This study aimed to evaluate the effect of supplementation with ground flaxseed (GF) on the concentrations of adiponectin, resistin, and visfatin in patients with UC.Methods: This trial is an open-labeled randomized controlled trial conducted among 70 patients with UC. Patients were randomly divided into two groups: flaxseed and control. Patients in the intervention were received 30 g/day flaxseed powder for 12 weeks. Patients' anthropometric, nutritional, and biochemical factors were evaluated at the beginning and end of the intervention period.Finding: Totally, 64 patients (36 men and 28 women) with a mean age of 31.12 ± 9.67 were included in the final analysis. There wasn’t any significant difference between the two groups regarding baseline weight and height (p>0.05). After the 12 weeks' intervention, flaxseed supplementation led to a significant reduction in the resistin (-4.85 ± 1.89 vs. -1.10 ± 2.25, p<0.001) and visfatin concentration (-1.33± 1.14 vs. -0.53 ± 1.63, p=0.018). Moreover, we found a significant increase in the adiponectin levels after the GF supplementation (3.49 ± 1.29 vs. -0.35 ± 0.96, p<0.001).Conclusion: It has been reported in this study that flaxseed supplementation could exert beneficial effects on adipokine levels in patients with UC. Trial registration: IRCT registration no. IRCT20180311039043N1
"U Puna Maisi'a Yari Maisi'a": Kajian Teologi Kontekstual Terkait Pandangan Orang Maneo di Seram Utara tentang Tanah dan Hutan bagi Kemanusiaan Mereka
Authors: Paays Hendrik Jondri , Gaspersz Steve G. Ch. , Hetharia Henky H. 
Published: May 2022

AbstractThis article examines the perspective of the Maneo community on land and forest as identity. Based on an oral tradition, the Maneo people understand land and forest as medium for meeting Lahatala (the supreme god, the creator, the sacred) and their ancestors to interconnect with other creations. The destruction and control of the land of the Maneo people not only destroy their lives and future but also harm their cultural andreligious identities. Using a qualitative research method, this article studies Maneo people’s views on land and forests in relation to their existence and identity. Through the presentation of Maneo’s perspective on U’puna maisi’a yari maisi’a as an entry point, this study explores the realities of land tenure and forest destruction in Maneo, and the way thechurch responds to the situation. As a conclusion, this article offers a contextual theology about humanizing humans in the concept of Maneo society.
AbstrakTulisan ini hendak menggali perspektif orang Maneo tentang tanah dan hutan sebagai identitas dirinya. Memegang teguh prinsip kultural (turun temurun dari) yang diturun-alihkan leluhur, orang Maneo memahami tanah dan hutan sebagai medium perjumpaan dengan Lahatala (Tuhan Pencipta, yang sakral) dan leluhur, serta sebagai cara berelasi dengan sesamanya dan ciptaan lainnya. Penulis menandaskan, penghancuran dan penguasan lahan tidak saja menjadi kekelaman masa depan orang Maneo, melainkan jugameluluhlantahkan identitas kultural dan religi mereka. Melalui metode pendekatan kualitatif, tulisan ini hendak menggali pandangan orang Maneo tentang tanah dan hutan bagi eksistensi dan identitas mereka. Pertama-tama, penulis memperlihatkan perspektif orang Maneo tentang U’puna maisi’a yari maisi’a. Hal itu menjadi pintu masuk untuk mendalami realitas gempuran penguasaan tanah dan pengrusakan hutan yang marak terjadi di Maneo. Lantas, bagaimana gereja memaknai fenomena tersebut. Akhirnya, tulisan ini diakhiri dengan tawaran teologi kontekstual tentang memanusiakan manusia dalam konsep orang Maneo.
Penerapan Metode Cambrigde Scriptural Reasoning Texts (CSRT) pada Kelas Pendidikan Agama Kristen di Universitas Kristen Duta Wacana
Authors: Minarni Nani 
Published: May 2022

Abstract The aim of this Classroom Action Experimental Research is to know the changing attitude of the students after implementing CSRT method. Christian Religious Education (CRE) at Duta Wacana Christian University (DWCU) emphasizes a multidisciplinary approach covering the fields of Sociology, Psychology, Theology, and Studies of Religions. Through CRE, students are expected to embrace inclusive and respectable attitudes as Indonesian citizens. How do CRE materials support the formation of inclusive and respectable attitudes? One of the teaching materials is the Interpretation of Scriptural Texts that are theoretically taken from the thoughts of John Hayes and Holladay in Biblical Exegesis, while the form of development of the theoretical interpretation exercise uses the “Cambridge Scriptural Reasoning Texts (CSRT)” method. The CSRT method was tested in one of the CRE classes as a “research sample”. The finding shows that students’ insights and perspectives were more open after learning hermeneutics using the CSRT method.
Abstrak Penelitian Tindakan Kelas Experimental ini bertujuan untuk melihat perubahan sikap mahasiswa setelah menerapkan metode CSRT. Pendidikan Agama Kristen (PAK) di UKDW menekankan pada pendekatan multidisiplin yang meliputi bidang Sosiologi, Psikologi, Teologi, dan Studi Agama-agama. Melalui PAK, mahasiswa diharapkan semakin dikuatkan dalam menghidupi sikap inklusif dan respek sebagai warga bangsa Indonesia. Bagaimana materi PAK mendukung pembentukan sikap inklusif dan respek? Salah satu materi bahan ajar PAK di UKDW yakni Interpretasi Teks Kitab Suci yang secara teoritik diambil dari pemikiran John Hayes dan Holladay dalam Biblical Exegesis, sedangkan bentuk pengembangan dari latihan interpretasi atas teori tersebut digunakan metode “Cross Scriptural Reasoning Texts (CSRT)”. Metode CSRT tersebut diujikan dalam salah satu kelas PAK sebagai “sampel penelitian”, didapati bahwa wawasan dan cara pandang mahasiswa semakin terbuka setelah belajar hermeneutik dengan metode CSRT.
Mengidungkan Macapat Injil lewat Lectio Divina: Sebuah Usaha Membumikan Kitab Suci dalam Budaya Jawa
Authors: Aryanto Antonius Galih Arga Wiwin , Kurniawan Agustinus Brian 
Published: May 2022

AbstractThe conversion of the Gospel texts into the Javanese song (macapat) is a strategic effort to enroot the Word of God in the Javanese culture. The process of conversion requires a mastery of the formula of macapat comprising guru lagu, guru gatra, and guru wilangan. Sindhunata and Suwandi have conducted a research project on such conversion. Thisarticle suggests that the method of lectio divina, as a tradition of bible reading in the Church to contemplate the word of God, can be employed in singing the Gospel macapat. Merging the two traditions helps believers experience the Word through the process of ngeningke cipta, nggegilut sabda, and nglelimbang sabda suci.
AbstrakPenerjemahan teks Injil ke dalam macapat Jawa merupakan langkah strategis untuk membumikan Sabda Allah dalam budaya Jawa. Tentu saja penerjemahan tersebut membutuhkan keahlian menguasai rumus-rumus tembang Jawa, yaitu guru lagu, guru gatra, dan guru wilangan, dan menyelaraskan terjemahan teks Injil Jawa dalam rumusan tersebut. Paper penelitian tentang macapat Injil karya Sindhunata dan Suwandi berupaya untuk memahami proses penerjemahan dari teks Injil bahasa Jawa menjadi teks macapat Jawa. Tulisan ini berpendapat bahwa teks macapat Injil ini bisa ditembangkan dan didalami dengan metode lectio divina, sebagai sebuah metode tradisional Gereja agar orang beriman bisa meresapi makna sebuah teks Injil. Saat macapatan, orang beriman diundangmasuk pada kandungan makna terdalam dari sabda Allah, dan mengalami pertemuan dengan Sang Sabda sendiri lewat ngeningke cipta, nggegilut sabda, dan nglelimbang sabda suci.
The role of leukotriene receptor blockers in the treatment of allergic rhinitis in combination with chronic rhinosinusitis with nasal polyps
Authors: Savlevich E. L. , Kurbacheva O. M. , Zurochka A. V. , Mitrofanova E. S. , Smolkin Yu. S. , Lyubimova E. V. 
Published: May 2022

Background. Leukotrienes play an important role in the pathogenesis of allergic rhinitis (AR) and eosinophilic type of chronic rhinosinusitis with nasal polyps (CRSwNP). There is a phenotype of CRSwNP in combination with AR, which has specifics of local inflammation.The aim of our study was to investigate the efficacy of using an antileukotriene drug in the treatment of AR in combination with CRSwNP.Materials and methods. 63 patients with AR and bilateral CRSwNP after endoscopic bilateral polypotomy were randomly divided into 2 groups. In the 1st group 32 people (age 50.28 ± 1.37 years) were prescribed a basic therapy with nasal spray of mometasone furoate at a daily dose of 400 µg in combination with montelukast 1 tab. 10 mg at night, in the 2nd group 31 people (age 50.31 ± 1, 16 years old) received only mometasone furoate monotherapy. Endoscopic examination of the nasal cavity was performed once every 3 months. The follow-up period was 1 year.Results. After 3 months in the 1st group of patients there was a recurrence of polyp growth was observed in 25% of cases, in the 2nd group in 35.5% of patients (p < 0.05). After 6 months, the number of relapses of CRSwNP decreased to 15.6% of cases in group 1 and to 22.6% in group 2 (p < 0.05). After 9 months in group 1 recurrence of NP was recorded in 12.5% of patients and nasal polyps were completely absent during endoscopic examination in 9.4% of cases, in the 2nd group, relapse was detected in 19.35% of patients (p < 0.05). 1 year after surgery, in group 1, relapse of NP was found in 12.5% of patients with AR and in 12.5% of cases was remission of the pathological process with cancellation of basic therapy. In group 2, recurrence of NP was in 16.1% of cases, there were no reasons for withdraw treatment of intranasal glucocorticosteroids in this group.Discussion. The clinical effectiveness of the addition of Montelukast to basic therapy has been reflected in a reduction in the growth rate of polyposic vegetation, the number of repeated operations and the stabilization of the flow of chronic inflammatory process.Conclusions. In the case of the clinical phenotype of AR with CRSwNP, the addition of a leukotriene receptor blocker montelukast to the basic therapy of intranasal glucocorticosteroids made it possible to improve drug control of both diseases and reduce the frequency of CRSwNP relapses.
Quality of life in patients with otosclerosis
Authors: Svistushkin V. M. , Sinkov E. V. , Stozhkova I. V. 
Published: May 2022

Introduction. One of the most relevant areas of modern medicine is research affecting the assessment of the quality of life of a person. Hearing loss can significantly limit various areas of life, thereby affecting the overall quality of life and certain particular characteristics. One of the methods of surgical treatment of otosclerosis is stapedoplasty with the installation of a titanium prosthesis.Aim of the study. To assess the quality of life index in patients with otosclerosis and its dynamics depending on the surgical treatment performed.Materials and methods. The study involved 39 patients who underwent piston stapedoplasty with the installation of a titanium prosthesis. Quality of life was assessed at the preoperative and postoperative stages. We used a Russified version of the SPOT-25 questionnaire (Stapesplasty Outcome Test 25) with a range of results, where 0 is the minimum impact, and 100 is the maximum.Results. All patients successfully underwent stapedoplasty. The average score in the preoperative period was 58.8 ± 14.9, in the postoperative period – 29.4 ± 20.4. Statistical comparison revealed a statistically significant improvement in all separately assessed indicators (p < 0.001) and overall quality of life (p < 0.001).Conclusion. The introduction into practice of a new tool for assessing the patient’s condition through such a parameter as quality of life can influence the rationale for the methods and tactics of patient treatment, which can positively affect the quality of medical care provided.
Evaluation of the efficacy and safety of the 7% hypertonic solution with hyaluronic acid in patients with COVID-19 in the outpatient phase
Authors: Anikin G. S. , Stozhkova I. V. , Sharonova S. S. , Kurdyukova E. V. 
Published: May 2022

Introduction. Since 2020, the pandemic caused by the SARS-CoV-2 virus poses a serious threat to health systems in many countries around the world. Finding inexpensive and affordable, effective and safe medications that can promote rapid recovery and reduce the risk of a severe course of COVID-19 is an important challenge for the health care system of any country. It has long been known that 7% hypertonic sodium chloride solution has nonspecific antiviral, antibacterial and antifungal properties. A 2020 study shows the effectiveness of hypertonic NaCl solutions in blocking SARS-CoV-2 replication in Vero cells. These data suggest that hypertonic solutions can be used as a prophylactic and alternative comprehensive treatment for patients with COVID-19.Aim. We study the efficacy and safety of hypertonic solution with hyaluronic acid in patients undergoing outpatient treatment with mild to moderate COVID-19.Materials and methods. We conducted an open prospective study of the use of hyaluronic acid (HA) solution 7% (Ingasalin® forte 7%) in outpatients with confirmed SARS-CoV-2 infection who had 1 or more risk factors for a severe course of the disease. Patients were divided into 2 groups of 30 patients each. The main group received, in addition to standard therapy (according to the interim guidelines in effect at the time of treatment, version 14 dated 12/27/21), inhalation of 7% HG with HA in the morning and evening for 10 days; patients in the control group received standard therapy according to the interim guidelines.Results and discussion. Patients of the study group who received hyaluronic acid solution 7% had statistically significant decrease of dyspnea and normalization of saturation values already on the 5th day of therapy compared to patients of the control group. One patient in the study group was hospitalized, and 4 patients in the control group were hospitalized. There were no side effects associated with the administration of hyaluronic acid solution 7%. Also, there was no development of cough or its intensification against the background of inhalation in patients of the main group.Conclusion. It is reasonable to use hyaluronic acid solution 7% in outpatients with mild to moderate COVID-19 and with one or more risk factors of severe disease course as part of complex therapy.
Evaluation of the antibacterial activity of the preparation benzydamine hydrochloride
Authors: Detusheva E. V. , Fursova N. K. , Kukes I. V. 
Published: May 2022

Introduction. With an increase in the level of acquired antibiotic resistance of pathogens, treatment becomes more complicated and slows down, especially in infections associated with biofilms. There is a growing need for the development and use of new antibacterial drugs with specific antimicrobial activity.Aim. To study the antimicrobial action and the dynamics of the formation of resistance to benzydamine hydrochloride from a various infection agents. Materials and methods. To obtain biofilms, microorganisms were cultivated in flat-bottomed culture plates. Planktonic cells were obtained by suspending and reseeding single colonies of the daily culture into flat-bottomed culture plates. To determine the antimicrobial activity of the studied preparations, two-fold dilutions were prepared and added to the wells of the plate with a bacterial culture. The dynamics of the formation of resistance to benzydamine hydrochloride was studied by passaging the cultures in a liquid nutrient medium with increasing concentrations of the antiseptic by a twofold step. After 2–3 days of incubation from a test tube with the maximum concentration of the drug, in which bacterial growth was observed, the bacteria were transferred to new ones with higher concentrations of the drug.Results. It was shown that benzydamine hydrochloride showed a high level of activity against bacteria M. catarrhalis and yeast-like fungi C. albicans. A slightly lower activity of the drug was noted for bacteria of the species S. aureus and E. coli, however, within the limits of the therapeutic concentration of the drug in finished dosage forms. Benzydamine hydrochloride had a significantly higher level of antibacterial activity against pre-formed biofilms compared to drugs such as chlorhexidine and hexetidine. An analysis of the dynamics of the formation of resistance to the drug benzydamine hydrochloride in microorganisms of various species showed that the possibility of developing resistance to benzydamine hydrochloride is extremely small. The process of adaptation was observed only in E. coli. The studied strains of the species S. aureus, C. albicans, and M. catarrhalis did not acquire resistance to the test drug.Conclusion. Benzydamine hydrochloride can be effectively used against a wide range of pathogens of ENT infections, as it has been shown to have a significantly higher level of antibacterial activity against pre-formed biofilms, various types of bacteria and yeast-like fungi and an extremely low level of resistance compared to other antiseptic drugs.