bluuebunny/crossref_metadata_2025_split huggingface dataset:
TATA CARA PENDAFTARAN MEREK DALAM USAHA MIKRO KECIL DAN MENENGAH (UMKM) DI LINGKUNGAN KARANG TARUNA PADALARANG KABUPATEN BANDUNG BARAT
Authors: Wahyudi  , Amalia Ananda Putri Nur 
Published: March 2022

This community service activity is organized by the Faculty of Law, Indonesian Computer University in collaboration with the Youth Organization Management, Padalarang District, West Bandung Regency. In the midst of the COVID-19 pandemic, the products of Micro, Small and Medium Enterprises (MSMEs) of the Padalarang District community continue to grow and become more diverse and almost every product has a brand, but the MSMEs brand owned has not been registered with the Directorate General of Intellectual Property. The method used is to conduct legal counseling through the media zoom meeting. The use of brands on MSMEs products can add higher selling value compared to unbranded products, MSMEs actors can be harmed if their products are used and even imitated in whole or in part by others because they sell well in the market. However, MSMEs actors cannot prevent and even sue because the mark has not been registered. Trademark registration is a must for MSME actors if they want to protect their rights to the mark. Trademarks to be registered are quite easy to use by utilizing online trademark registration, specifically for the registration of trademarks for MSMEs actors, the fees charged are lower than those of industrial marks. The legal protection of registered trademark rights is for 10 years and can be extended for the same time.

Kegiatan pengabdian kepada masyarakat ini diselenggarakan oleh Fakultas Hukum Universitas Komputer Indonesia bekerjasama dengan Pengurus Karang Taruna Kecamatan Padalarang Kabupaten Bandung Barat. Ditengah pandemi covid 19 produk Usaha Mikro Kecil dan Menengah (UMKM) masyarakat Kecamatan Padalarang terus berkembang dan semakin beragam serta hampir setiap produknya memiliki merek, akan tetapi merek UMKM yang dimiliki tersebut belum terdaftar pada Direktorat Jenderal Kekayaan Intelektual. Metode yang digunakan yaitu dengan melakukan penyuluhan hukum melalui media zoom meeting. Penggunaan merek pada produk UMKM dapat menambah nilai jual lebih tinggi dibandingkan dengan produk tanpa merek, pelaku UMKM dapat dirugikan jika produknya digunakan bahkan ditiru secara keseluruhan maupun sebagian oleh orang lain karena laku dipasaran. Akan tetapi pelaku UMKM tidak dapat mencegah bahkan menuntut dikarenakan merek tersebut belum didaftarkan. Pendaftaran merek menjadi suatu keharusan bagi pelaku UMKM jika ingin terlindungi hak atas merek tersebut. Merek yang akan didaftarkan cukup mudah dengan memanfaatkan pendaftaran merek secara online, khusus untuk pendaftaran merek pelaku UMKM biaya yang dikenakan lebih rendah dibanding dengan merek industri. Pelindungan hukum hak atas merek terdaftar selama 10 tahun dan dapat diperpanjang dengan waktu yang sama.
IMPLEMENTASI PENCEGAHAN KOMPLIKASI HIPERTENSI MELALUI THERAPEUTIC NAPE MASSAGE PADA LANSIA
Authors: Kurdi Fahruddin , Susumaningrum Latifa Aini , Rasni Hanny , Susanto Tantut 
Published: March 2022

Hypertension or what is commonly called high blood pressure is an increase in systolic blood pressure above the normal limit of more than 140 mmHg and diastolic blood pressure of more than 90 mmHg. The prevalence of hypertension in Jember Regency, the number of cases in 2014-2017 had the most cases, data on hypertension disease 22,185 cases in 2014 then increased to 29,683 in 2015. In 2017 the number of cases of hypertension occurred in women by 53,69% while men 46,31% of complications of hypertension that are left untreated will cause catastrophic disease. Hypertension is one of the diseases that often affects the elderly, but there are still many elderly people in Ledokombo District who pay less attention to their health so they don't check their blood pressure regularly. Headache is a problem that is often experienced by patients with hypertension. Halte Sehat Program is an effort made to control the health of hypertensive patients on a regular basis. Nape massage therapy is given to patients who have complaints of headache as a form of reduction in pharmacological therapy. As a result of giving therapy to 8 hypertension respondents, there were 6 respondents who experienced a decrease in pain scale and blood pressure. families are given education related to neck massage therapy so that the family can provide therapy to patients if they experience headache at any time.
Hipertensi atau yang biasa disebut tekanan darah tinggi adalah peningkatan tekanan darah sistolik di atas batas normal lebih dari 140 mmHg dan tekanan darah diastolik lebih dari 90 mmHg. Prevalensi hipertensi di Kabupaten Jember, jumlah kasus tahun 2014-2017 memiliki kasus terbanyak, data penyakit hipertensi 22.185 kasus pada tahun 2014 kemudian meningkat menjadi 29.683 pada tahun 2015. Pada tahun 2017 jumlah kasus hipertensi terjadi pada wanita sebesar 53,69% sedangkan laki-laki 46,31% komplikasi hipertensi yang tidak ditangani akan menyebabkan penyakit katastropik. Hipertensi merupakan salah satu penyakit yang sering menyerang lansia, namun masih banyak lansia di Kecamatan Ledokombo yang kurang memperhatikan kesehatannya sehingga tidak melakukan pemeriksaan tekanan darah secara rutin. Sakit kepala merupakan masalah yang sering dialami oleh penderita hipertensi. Program Halte Sehat merupakan upaya yang dilakukan untuk mengontrol kesehatan penderita hipertensi secara rutin. Terapi pijat tengkuk diberikan kepada pasien yang memiliki keluhan nyeri kepala sebagai bentuk pengurangan terapi farmakologis. Hasil dari pemberian terapi pada 8 responden hipertensi terdapat 6 responden yang mengalami penurunan skala nyeri dan tekanan darah. Keluarga diberikan edukasi terkait terapi pijat leher agar keluarga dapat memberikan terapi kepada pasien jika sewaktu-waktu mengalami sakit kepala.
PELATIHAN DALAM PENGGUNAAN INFORMED CONSENT PADA FASILITAS PELAYANAN KESEHATAN
Authors: Setiyoargo Arief , Marbun Romaden 
Published: March 2022

This Community Service activity aims to improve the quality of health services through understanding the use of informed consent. This activity begins with an initial assessment of the current state of the field in health care facilities through health workers/health cadres and residents. The initial assessment found that there was still a lack of public knowledge about medical treatment for patients and knowledge related to the use of informed consent in health facilities, especially during the current Covid-19 pandemic, the focus of health services is still centered on health protocols or physical distancing. The activity begins with preparing a plan and schedule of activities as well as the necessary equipment. The form of activities is packaged in the form of materials and videos that are shared via Google Drive online via WhatsApp groups. The activity ended with an evaluation using a google form. The results of community service activities there are as many as 57,69% of citizens' understanding in the good category, 26,92% sufficient and 15,38% less. Activities are going well and need further monitoring.

Kegiatan Pengabdian kepada Masyarakat ini bertujuan untuk meningkatkan kualitas pelayanan kesehatan melalui pemahaman penggunaan informed consent. Kegiatan ini diawali dengan penilaian awal kondisi terkini di lapangan di fasilitas pelayanan kesehatan melalui petugas kesehatan/kader kesehatan dan warga. Asesmen awal menemukan masih kurangnya pengetahuan masyarakat tentang penanganan medis bagi pasien dan pengetahuan terkait penggunaan informed consent di fasilitas kesehatan terutama pada masa pandemi Covid-19 saat ini, fokus pelayanan kesehatan masih berpusat pada kesehatan, protokol atau jarak fisik. Kegiatan diawali dengan penyusunan rencana dan jadwal kegiatan serta perlengkapan yang diperlukan. Bentuk kegiatan dikemas dalam bentuk materi dan video yang dibagikan melalui google drive secara online melalui grup WhatsApp. Kegiatan diakhiri dengan evaluasi menggunakan google form. Hasil kegiatan pengabdian masyarakat terdapat sebanyak 57,69% pemahaman warga dalam kategori baik, 26,92% cukup dan 15,38% kurang. Kegiatan berjalan dengan baik dan perlu pemantauan lebih lanjut.
PEMBERDAYAAN MASYARAKAT DALAM UPAYA PENCEGAHAN PENYEBARAN COVID-19 DENGAN PENERAPAN TEKNOLOGI TEPAT GUNA DI AREA BERMAIN BALITA LINGKUNGAN RW 014 KELURAHAN SERUA, CIPUTAT
Authors: Heriani Heriani , Prastati Trini , Purnama Rahmad , Silawati Tutisiana , Madya Faizal , Ni mah Alfiatun 
Published: March 2022

Memasuki era Kebiasaan Baru (New normal) ini, aktivitas masyarakat perlahan kembali seperti sebelum pandemi dengan syarat protokol kesehatan harus selalu diperhatikan, dijalankan, dan ditaati. Para balita yang sudah mulai bosan bermain di dalam rumah, ingin bermain di luar rumah. Namun lingkungan pemukiman rumah belum mendukung dikarenaka tidak tersedia arena bermain yang dapat menjadi wahana bagi balita untuk bermain sambil belajar, belajar bergaul dengan kawan sebaya, belajar berinteraksi dengan kawan sebaya sambil menggunakan sarana/alat permainan, dan belajar mandiri dalam bermain sambil diawasi Ayah, Bunda, atau Pengasuh. Melalui Program Pengabdian Masyarakat ini, tim mencoba untuk membantu masyarakat mewujudkan kebutuhan akan ruang bermain anak yang dilengkapi dengan fasilitas penunjang protokol Kesehatan untuk mencegah Penyebaran Covid-19 yang ramah lingkungan dan ramah penyandang disabilitas berupa tempat cuci tangan otomatis (Touch less) bertenaga surya. Selain membantu dalam menyediakan alat teknologi tepat guna tersebut, Pengabdian kepada Masyarakat ini juga akan melakukan sosialisasi mengenai protokol kesehatan dan pentingnya waktu bermain kepada anak-anak dan orang tua di lingkungan RW 014 Bukit Nusa Indah, Kelurahan Serua, Ciputat, Kota Tangerang Selatan.
PENATAAN MANAJEMEN KOPERASI SERBA USAHA, MASJID AL HUSNA, BUKIT INDAH, SERUA, CIPUTAT
Authors: Silawati Tutisiana , Toha Mohamad , Mardoni Yosi , Aslichati Lilik , Tampi Yoga Mohamad , Parashtiwi Ninggar 
Published: March 2022

Al Husna Bukit Indah Mosque, Serua Village, since 2007, has 680 members. The business run is savings and loan and the sale of goods and services. To manage finances, activities are still done manually. The manager is retirees whose knowledge of the management of Sharia-based Multipurpose Cooperatives tends to be lacking. This community service activity intends to develop financial applications and manage management. The methods used are: 1) Identifying financial data that needs to be included in financial applications; 2) Developing financial applications; and 3) Training and assisting Al Husna Mosque administrators to use financial applications, and conducting counseling about business entities that comply with sharia principles. In this way, it is hoped that the Al Husna mosque will be able to manage its business and finances better and be able to provide better services to its members.

KSU-BMT Masjid Al Husna Bukit Indah, Kelurahan Serua, yang berfungsi untuk menyalurkan dana sosial dan juga sebagai koperasi sejak 2007, memiliki anggota sebanyak 680 orang. Usaha yang dijalankan berbentuk simpan pinjam dan penjualan barang dan jasa. Untuk mengelola keuangan kegiatan masih dilakukan dengan cara manual. Akibat dari aplikasi system keuangan yang pernah dimiliki rusak. Pengelola pun para pensiunan yang pengetahuan mereka tentang pengelolaan Koperasi Serba Usaha berbasis Syariah cenderung terbatas. Kegiatan pengabdian kepada masyarakat ini bermaksud melakukan pengembangan aplikasi keuangan dan penataan manajemen di Masjid ini. Metode yang dilakukan adalah: 1) Mengidentifikasi data keuangan yang perlu dimasukkan dalam aplikasi keuangan; 2) Mengembangkan aplikasi keuangan; dan 3) Melatih serta mendampingi pengurus Masjid Al Husna menggunakan aplikasi keuangan, dan melakukan penyuluhan tentang badan usaha yang memenuhi prinsip-prinsip syariah. Dengan cara demikian diharapkan nantinya masjid Al Husna mampu mengelola usaha dan keuangan secara lebih sistematis. Akhirnya akan memberi pelayanan lebih baik kepada seluruh anggota.
Body Mass Index, Interleukin-6 Signaling and Multiple Sclerosis: A Mendelian Randomization Study
Authors: Vandebergh Marijne , Becelaere Sara ,   CHARGE Inflammation Working Group, Dubois Bénédicte , Goris An 
Published: March 2022

ObjectivesWe explored whether genetically predicted increased body mass index (BMI) modulates multiple sclerosis (MS) risk through interleukin-6 (IL-6) signaling.MethodsWe performed a two-sample Mendelian randomization (MR) study using multiple genome-wide association studies (GWAS) datasets for BMI, IL-6 signaling, IL-6 levels and c-reactive protein (CRP) levels as exposures and estimated their effects on risk of MS from GWAS data from the International Multiple Sclerosis Genetics Consortium (IMSGC) in 14,802 MS cases and 26,703 controls.ResultsIn univariable MR analyses, genetically predicted increased BMI and IL-6 signaling were associated with higher risk of MS (BMI: odds ratio (OR) = 1.30, 95% confidence interval (CI) = 1.15-1.47,p= 3.76 × 10-5; IL-6 signaling: OR = 1.51, 95% CI = 1.11-2.04,p= 0.01). Furthermore, higher BMI was associated with increased IL-6 signaling (β = 0.37, 95% CI = 0.32,0.41,p= 1.58 × 10-65). In multivariable MR analyses, the effect of IL-6 signaling on MS risk remained after adjusting for BMI (OR = 1.36, 95% CI = 1.11-1.68,p= 0.003) and higher BMI remained associated with an increased risk for MS after adjustment for IL-6 signaling (OR = 1.16, 95% CI =1.00-1.34,p= 0.046). The proportion of the effect of BMI on MS mediated by IL-6 signaling corresponded to 43% (95% CI = 25%-54%). In contrast to IL-6 signaling, there was little evidence for an effect of serum IL-6 levels or CRP levels on risk of MS.ConclusionIn this study, we identified IL-6 signaling as a major mediator of the association between BMI and risk of MS. Further explorations of pathways underlying the association between BMI and MS are required and will, together with our findings, improve the understanding of MS biology and potentially lead to improved opportunities for targeted prevention strategies.
Nutrition Knowledge as a Driver of Adherence to the Mediterranean Diet in Italy
Authors: Aureli Vittoria , Rossi Laura 
Published: March 2022

BackgroundAn optimal Nutrition knowledge (NK) among the population could result in greater Adherence to the Mediterranean Diet (AMD), a recognized dietary pattern capable of preventing chronic food-related diseases. This study aimed to evaluate the association between NK and AMD in Italy.MethodsA national representative sample of 2,869 adults took part in an assessment that was carried out through a self-administrated questionnaire including sections relating to NK and AMD. AMD was evaluated following the PREDIMED PLUS methodology. Descriptive statistics were provided, and ordinal measures of NK score and AMD were calculated based on quartiles of the quantitative scores. A contingency analysis was performed to check associations between variables.ResultsIn Italy, the average NK score was 50 ± 13.3, equivalent to 56.8% of correct answers. The average value of AMD was 6.8, corresponding to 40% of the maximum score with 31.4% of the population demonstrating low AMD, 31.3% in the lower-middle range, 24% in the medium-high range, and only 13.3% reporting a high AMD. A significant association between NK and AMD was found; respondents who reported the lowest AMD corresponded to those with the lowest NK (36.7%; p &lt; 0.05) and similarly, those with the highest level of adherence to MD also achieved the highest NK scores (41.7%; p &lt; 0.05).ConclusionThis study showed that AMD in Italy is generally low, and the strong association between NK and AMD demonstrated that there is a clear connection between a healthy dietary pattern and the nutrition literacy of the population. Those with the highest AMD corresponded to the highest NK and, conversely, those with the lowest AMD displayed the lowest NK. The study also highlighted that socioeconomic aspects were strong determinants of both AMD and NK.
Transcriptome Changes and Potential Immunotoxicity Analysis in RAW264.7 Macrophages Caused by Bisphenol F
Authors: Chen Huiling , Zhang Yanchao , Li Xing , Zhang Wei , He Haoqi , Du Bohai , Li Tianlan , Tang Huanwen , Liu Yungang , Li Li , Shi Ming 
Published: March 2022

As a viable substitute for bisphenol A (BPA), BPF has been widely used in the plastic industry and daily consumer goods, resulting in its detection in humans at a comparable concentration. Evidence reveals that BPF and BPA may have similar toxic effects due to their similar structures. However, there is less information about BPF and its latent implications on the immune system, which is associated with many disorders. In this study, the in vitro toxicity of BPF on RAW264.7 macrophages was explored. The cells were treated with different concentrations of BPF (5, 10, 20, 50, 100, and 200 μM), the cell viability and apoptosis were detected, the gene expression profile was analyzed by whole-transcriptome sequencing, and the mRNA levels were detected by qRT-PCR. The results showed a high concentration of BPF could significantly reduce the survival rate of RAW264.7 macrophages. Although the medium concentration (20–50 μM) of BPF seemed to have no impact on the cell activity of macrophages, it caused the occurrence of apoptosis. The results of differential transcription showed that compared with the control group, 121 genes were upregulated and 82 genes were downregulated in the BPF group. The significantly changed gene functions were mainly concentrated in cell cycle, phagosome, lysosome, and antigen processing and presentation. These findings provide valuable information for correctly understanding the immunotoxicity risk of BPF and may help to improve the hazard identification of bisphenol compounds.
Effects of Motherwort Injection Versus Intramuscular Oxytocin for Preventing Postpartum Hemorrhage Among Women Who Underwent Cesarean Section
Authors: Li Ming-xi , Liu Chun-rong , Chen Meng , Shang Hong-cai , Wang Wen , Luo Xiao-chao , Li Ling , Qi Ya-na , Xiong Yi-quan , Huang Shi-yao , Wang Jing , Zou Kang , Liu Xing-hui , Tan Jing , Sun Xin 
Published: March 2022

Objectives: Subject to ethical constraints, real-world data are an important resource for evaluating treatment effects of medication use during pregnancy and the postpartum period. This study investigated whether motherwort injection, a traditional Chinese medicine preparation, was more effective than intramuscular (IM) oxytocin for preventing postpartum hemorrhage (PPH) in a real-world setting when intravenous (IV) oxytocin is administered.Methods: We conducted an active-controlled, propensity-score matched cohort study using an established pregnancy registry database. Women who underwent cesarean section and received IV oxytocin at the third stage of labor were included. We used an active-comparator design to minimize indication bias, in which we compared IM motherwort injection in the uterus versus IM oxytocin, both on top of IV oxytocin use. We applied 1:1 propensity-score matching (PSM) to balance patient baseline characteristics and used a logistic regression model to estimate treatment effect (i.e., risk difference (RD) and odds ratio (OR)) by using the counterfactual framework. The outcomes of interest were blood loss over 500 ml within 2 h after delivery (PPH, primary) and blood loss over 1,000 ml (severe PPH, secondary). We conducted four sensitivity analyses to examine the robustness of the results.Results: A total of 22,519 pregnant women underwent cesarean sections, among which 4,081 (18.12%) PPH and 480 (2.13%) severe PPH occurred. Among included women, 586 (2.60%) were administrated with IM motherwort injection, and 21,933 (97.40%) used IM oxytocin. After PSM, patient baseline characteristics were well balanced. Compared with IM oxytocin, the use of IM motherwort injection was associated with significantly lower risk of PPH (RD −25.26%, 95% CI −30.04% to −20.47%, p &lt; 0.001; OR 0.25, 95% CI 0.18 to 0.32, p &lt; 0.001) and severe PPH (RD −3.58%, 95% CI −5.87% to −1.30%, p &lt; 0.001; OR 0.39, 95% CI 0.20 to 0.71, p &lt; 0.002). Sensitivity analyses showed that the results were similar.Conclusion: With the use of data from a real-world setting, the findings consistently showed that among women undergoing cesarean section who had received IV oxytocin, the additional use of IM motherwort injection could achieve a lower risk of PPH as compared to the additional use of IM oxytocin. Our study suggested a paradigm for investigating the treatment effect of Chinese herbal medicine in the real-world practice setting.
A Novel Staining Method for Detection of Brain Perivascular Injuries Induced by Nanoparticle: Periodic Acid-Schiff and Immunohistochemical Double-Staining
Authors: Onoda Atsuto , Hagiwara Shin , Kubota Natsuko , Yanagita Shinya , Takeda Ken , Umezawa Masakazu 
Published: March 2022

Background: To protect developing brain from any unfavorable effects, it is necessary to construct experimental techniques that can sensitively detect and evaluate developmental toxicity. We have previously shown that brain perivascular tissues, especially perivascular macrophages (PVMs), respond sensitively even to weak stimuli by foreign toxicants such as low-dose exposure to nanoparticle. This paper shows the protocol of a novel staining method that enables easy detection and rapid evaluation of brain perivascular abnormalities.Methods: As weak stimulus, low-dose of carbon black nanoparticle (95 μg/kg) or titanium dioxide nanoparticle (100 μg/kg) was intranasally administered to pregnant mice at gestational days 5 and 9. The offspring brains were used to confirm the properties of PVMs and to find suitable protocols for the detection and evaluation of the mild denaturation of PVMs. Furthermore, various procedures of novel combinational double staining including periodic acid-Schiff (PAS) staining and immunohistochemistry were examined. In addition, we checked the alterations in neurotransmitter levels and the behaviors of the offspring.Results and discussion: Maternal exposure to low-dose of nanoparticle at levels where no significant effects on the brain were observed, such as abnormal behavior, alteration of neurotransmitter levels, or microglial activation, resulted in mild denaturation of the PVMs, which was captured by PAS staining. However, it was difficult to detect and determine slight histopathological alterations. Therefore, we established PAS-immunohistochemical double-staining method for the brain. This double staining method enabled easy detection and rapid evaluation of brain perivascular abnormalities and the relationship between PVMs and the surrounding cells. In addition, this double staining allows evaluation of the histopathological denaturation of the PVMs and the associated abnormalities in the surrounding tissues in the same section.Conclusion: The slight responses of brain perivascular tissues, such as mild denaturation of PVMs, were sensitively and easily determined by the PAS-immunohistochemical double-staining method. This double staining method is a powerful tool to assess brain perivascular injuries including PVM denaturation and the relationship between the expression of various molecules and the morphology of PVMs. We propose that the observation of the tissue around brain blood vessels using the double staining provides potential endpoints to evaluate developmental neurotoxicity.