bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic and phenotypic correlations between Aleutian disease tests with body weight, growth, and feed efficiency traits in mink
Authors: Hu Guoyu , Do Duy Ngoc , Davoudi Pourya , Manafiazar Ghader , Kelvin Alyson A , Plastow Graham , Wang Zhiquan , Sargolzaei Mehdi , Miar Younes 
Published: October 2022

Abstract
The ineffectiveness of vaccination, medicine, and culling strategy leads mink farmers to control Aleutian disease (AD) by selecting AD-resilient mink based on AD tests. However, the genetic background of AD tests and their correlations with economically important or AD-resilient traits are limited. This study estimated the genetic and phenotypic correlations between four AD tests and seven body weight (BW) traits, six growth parameters from the Richards growth model, and eight feed-related traits. Univariate models were used to test the significance (P &lt; 0.05) of fixed effects (sex, color type, AD test year, birth year, and row-by-year), random effects (additive genetic, maternal genetic, and permanent environmental), and a covariate of age using ASReml 4.1. Likewise, pairwise bivariate analyses were conducted to estimate the phenotypic and genetic correlations among the studied traits. Both antigen- and virus capsid protein-based enzyme-linked immunosorbent assay tests (ELISA-G and ELISA-P) showed significant (P &lt; 0.05) moderate positive genetic correlations (±SE) with maturation rate (from 0.36 ± 0.18 to 0.38 ± 0.19). ELISA-G showed a significant negative genetic correlation (±SE) with average daily gain (ADG, −0.37 ± 0.16). ELISA-P showed a significant positive moderate genetic correlation (±SE) with off-feed days (DOF, 0.42 ± 0.17). These findings indicated that selection for low ELISA scores would reduce the maturation rate, increase ADG (by ELISA-G), and minimize DOF (by ELISA-P). The iodine agglutination test (IAT) showed significant genetic correlations with DOF (0.73 ± 0.16), BW at 16 weeks of age (BW16, 0.45 ± 0.23), and BW at harvest (HW, −0.47 ± 0.20), indicating that selection for lower IAT scores would lead to lower DOF and BW16, and higher HW. These estimated genetic correlations suggested that the selection of AD tests would not cause adverse effects on the growth, feed efficiency, and feed intake of mink. The estimates from this study might strengthen the previous finding that ELISA-G could be applied as a reliable and practical indicator trait in the genetic selection of AD-resilient mink in AD-positive farms.
Using the multi-component induction logging data to evaluate the geometric parameters of the hydraulic fracture
Authors: Kang Zhengming , Zhang Yi , Hou Binbin , Chen Gang , Hao Xiaolong , Qin Haojie , Qin Wenjuan 
Published: October 2022

Abstract
Hydraulic fracturing technology can effectively improve the seepage capacity of low-porosity and -permeability reservoirs. Geometric parameters evaluation (height, aperture and length) of hydraulic fracture is essential at different stages of fracturing. This paper presents a new method to evaluate the three parameters of small-scale fractures by multi-component induction logging based on numerical simulations. First, the model of calculation of the induced electric field with vertical hydraulic fractures is established using a three-dimensional finite element method (3D FEM), and the algorithm is verified correctly by comparing it with the analytical solution. Five coil systems of xx, xz, yy, yz and zz that are sensitive to the geometric parameters of the fracture are determined. The relationships between the geometric parameters of the fracture and the measurement signals of five coils are then investigated. The results show that the length and aperture of the fracture have a power exponent relationship with the measurement voltage, while the height parameter is closely related to the logging curves. Based on the relationships, the calculation models of the geometric parameters are established and the applicable range of it is analyzed. It is demonstrated that the complete characterization of fracture geometric can be realized by combining multi-spacing and multi-coil systems. Finally, the influence of the borehole and surrounding formation on the measurements is also considered, and the results indicate that the resistivity of the formation has less influence on the signals than the resistivity of the mud. Compared to the current instrument, the new method can evaluate all three geometric parameters of the hydraulic fracture.
Borehole radiation and reception responses for azimuthal shear-wave reflection imaging with an off-centred dipole acoustic tool
Authors: Li Yanghu , Tang Xiaoming , Su Yuanda 
Published: October 2022

Abstract
Radiation and reception responses of a dipole acoustic logging tool placed eccentrically in borehole fluid are an interesting and important topic in acoustic reflection imaging. Herein, we present a thorough research study on these responses. We treat the wave incidence from the reflector as the radiation from a virtual source and use the cylindrical-wave expansion method to solve both the wave radiation and reception problems for the off-centred tool, which, by using the steepest-descent method, yields asymptotic solutions for modelling the radiation and reception wavefield characteristics. The modelling results from the analytical solution and the 3D finite-difference method were in good agreement. Specifically, we analysed the radiation directivity of an eccentric dipole source in a fluid-filled borehole. The results revealed that the radiation pattern was asymmetric with respect to the borehole, and the asymmetry was determined by the eccentric distance, source frequency and formation properties. In particular, for the typical 3 kHz dipole logging frequency, the radiation was stronger in the off-centred direction than in the opposite direction. The asymmetry of the eccentric radiation resulted in a significant amplitude difference relative to its centred counterpart, which provided a potential method for addressing the 180° azimuth ambiguity of the dipole source. We used a theoretical waveform modelling example to demonstrate this advantage. Therefore, the results of this study provide a theoretical foundation for the development and application of dipole shear-wave imaging technology.
Body Mass Index Trajectories Across the Adult Life Course and Pancreatic Cancer Risk
Authors: Arjani Simran , Saint-Maurice Pedro F , Julián-Serrano Sachelly , Eibl Guido , Stolzenberg-Solomon Rachael 
Published: October 2022

Abstract

Background
Body mass index (BMI) during adulthood has been associated with pancreatic ductal adenocarcinoma (PDAC), however, patterns of body size across the adult life course have not been studied extensively. We comprehensively evaluated the association between adiposity across adulthood and PDAC.

Methods
We conducted a prospective analysis of 269 480 (162 735 males, 106 745 females) National Institutes of Health–AARP Diet and Health Study participants, aged 50-71 years (1995-1996) who self-reported height and weight history. Participants were followed through December 31, 2011. We examined associations between BMI (kg/m2) at ages 18, 35, 50, and 50-71 (baseline) years, their trajectories determined from latent-class trajectory modeling, and incident PDAC. Cox proportional hazard models were used to calculate multivariable adjusted hazards ratios (HRs) and 95% confidence intervals (CIs).

Results
During up to 15.2 years of follow-up, 3092 (2020 males, 1072 females) patients with incident PDAC were identified. BMI at all 4 ages were statistically significantly associated with increased PDAC (per 5-unit increase, HR = 1.09-1.13) with higher magnitude associations in males than females at ages 35 years and older (Pinteraction &lt; .05). Four BMI trajectories were created. Compared with normal-weight maintainers, normal-to-overweight, normal-to-obese class I, and overweight-to-obese class III trajectories had hazard ratios of 1.15 (95% CI = 1.06 to 1.25), 1.39 (95% CI = 1.25 to 1.54), and 1.48 (95% CI = 1.18 to 1.87), respectively (Pinteraction by sex = .07).

Conclusions
High BMI and BMI trajectories that result in overweight or obesity during adulthood were positively associated with PDAC, with stronger associations among those with early onset adiposity and those with male sex. Avoidance of excess body weight throughout the adult life course may prevent PDAC.
Circumbinary discs for stellar population models
Authors: Izzard Robert G , Jermyn Adam S 
Published: October 2022

ABSTRACT
We develop a rapid algorithm for the evolution of stable, circular, circumbinary discs suitable for parameter estimation and population synthesis modelling. Our model includes disc mass and angular momentum changes, accretion on to the binary stars, and binary orbital eccentricity pumping. We fit our model to the post-asymptotic giant branch (post-AGB) circumbinary disc around IRAS 08544−4431, finding reasonable agreement despite the simplicity of our model. Our best-fitting disc has a mass of about $0.01\, \mathrm{M}_{\odot }$ and angular momentum $2.7\times 10^{52}\, \mathrm{g}\, \mathrm{cm}^{2}\, \mathrm{s}^{-1}\simeq 9 \,\mathrm{M}_{\odot }\, \mathrm{km}\, \mathrm{s}^{-1}\, \mathrm{au}$, corresponding to 0.0079 and 0.16 of the common-envelope mass and angular momentum, respectively. The best-fitting disc viscosity is αdisc = 5 × 10−3 and our tidal torque algorithm can be constrained such that the inner edge of the disc Rin ∼ 2a. The inner binary eccentricity reaches about 0.13 in our best-fitting model of IRAS 08544−4431, short of the observed 0.22. The circumbinary disc evaporates quickly when the post-AGB star reaches a temperature of $\sim \! 6\times 10^4\, \mathrm{K}$, suggesting that planetismals must form in the disc in about $10^{4}\, \mathrm{yr}$ if secondary planet formation is to occur, while accretion from the disc on to the stars at ∼10 times the inner-edge viscous rate can double the disc lifetime.
The Traspena meteorite: heliocentric orbit, atmospheric trajectory, strewn field, and petrography of a new L5 ordinary chondrite
Authors: Andrade Manuel , Docobo José Á , García-Guinea Javier , Campo Pedro P , Tapia Mar , Sánchez-Muñoz Luis , Villasante-Marcos Víctor , Peña-Asensio Eloy , Trigo-Rodríguez Josep M , Ibáñez-Insa Jordi , Campeny Marc , Llorca Jordi 
Published: October 2022

ABSTRACTThe Traspena meteorite fell on 2021 January 18 about 20 km south-east of the city of Lugo (Galiza, Spain), shortly after a huge and bright fireball crossed the sky for 4.84 s. Astrometric measurements obtained from the fireball cameras of the Universidade de Santiago de Compostela (USC) as well as from many casual videos were used to determine the atmospheric trajectory of this meteoroid which penetrated the atmosphere and generated sound waves that were detected at three seismic stations. The original meteoroid had a diameter of about 1.15 m and a mass around 2620 kg. It impacted the Earth’s atmosphere with a steep entry angle of about 76${_{.}^{\circ}}$7 from a height of 75.10 km until fading away at 15.75 km with a velocity of 2.38 km s−1. Before the impact, this small asteroid was orbiting the Sun with a semimajor axis of 1.125 au, a moderate eccentricity of 0.386, and a low inclination of 4${_{.}^{\circ}}$55. A weak evidence of dynamic link with the PHA (Potential Hazardous Asteroid) Minos was investigated. During the atmospheric entry, two major fragmentation events occurred between heights of 35 and 29 km at aerodynamic pressures between 1 and 5 MPa. The strewn field was computed after calculating the individual dark flights of the main body along with two smaller fragments. Fortunately, 2 month after the superbolide, a 527-g meteorite was found. It was examined using several geochemical and petrographic analyses which allowed us to classify it as a moderately shocked (S3) L5 ordinary chondrite with a bulk density of 3.25 g cm−3.
Smoke on the wind: dust nucleation in the archetype colliding-wind pinwheel WR 104
Authors: Soulain A , Lamberts A , Millour F , Tuthill P , Lau R M 
Published: October 2022

ABSTRACT
A handful of binary Wolf–Rayet stars are known to harbour spectacular spiral structures spanning a few hundred astronomical units. These systems host some of the highest dust production rates in the Universe and are therefore interesting candidates for addressing the origin of the enigmatic dust excess observed across galactic evolution. The substantial interaction between the winds of a Wolf–Rayet star and its companion constitutes a unique laboratory in which to study the mechanisms of dust nucleation in a hostile environment. Using the grid-based ramses code, we investigate this problem by performing a 3D hydrodynamic simulation of the inner region of the prototypical spiral nebula around WR 104. We then process the ramses results using the radiative transfer code RADMC3d to generate a candidate observable scene. This allows us to estimate the geometrical parameters of the shocked region. We link these quantities to the specific chemical pathway for dust nucleation, where the hydrogen-rich companion’s wind catalyses dust formation. The scaling laws we derive constitute a unique tool that can be directly compared with observations. Depending on the dust nucleation locus, the velocity field reveals a differential wind speed, implying that the initial dust speed could be more balanced between the speeds of the two stellar winds ($\sim$1600 km s–1). With RA DMC3d, we provide constraints on the dust nucleation radius for different combinations of the dust-to-gas ratio, hydrogen fraction, and dust grain properties. Finally, our models reveal that dust may escape beyond the boundaries of the spiral owing to hydrodynamical instabilities in the wind collision zone.
Possible effects of dietary advanced glycation end products on maternal and fetal health: a review
Authors: Demirer Büşra , Samur Gülhan 
Published: October 2022

Abstract
Excessive accumulation of advanced glycation end products (AGEs) in the body has been associated with many adverse health conditions. The common point of the pathologies associated at this point is oxidative stress and inflammation. Pregnancy is an important period in which many physiological, psychological, and biological changes are experienced. Along with the physiological changes that occur during this period, the mother maintaining an AGE-rich diet may cause an increase in the body's AGE pool and may increase oxidative stress and inflammation, as seen in healthy individuals. Studies have reported the negative effects of maternal AGE levels on maternal and fetal health during pregnancy. Although gestational diabetes, preeclampsia, endothelial dysfunction, and pelvic diseases constitute maternal complications, a number of pathological conditions such as intrauterine growth retardation, premature birth, neural tube defect, neurobehavioral developmental disorders, fetal death, and neonatal asphyxia constitute fetal complications. It is thought that the mechanisms of these complications have not been confirmed yet and more clinical studies are needed on this subject. The possible effects of dietary AGE levels during pregnancy on maternal and fetal health are examined in this review.
Current insights into posttranscriptional regulation of fleshy fruit ripening
Authors: Wang Weihao , Wang Yuying , Chen Tong , Qin Guozheng , Tian Shiping 
Published: October 2022

Abstract
Fruit ripening is a complicated process that is accompanied by the formation of fruit quality. It is not only regulated at the transcriptional level via transcription factors or DNA methylation but also fine-tuned after transcription occurs. Here, we review recent advances in our understanding of key regulatory mechanisms of fleshy fruit ripening after transcription. We mainly highlight the typical mechanisms by which fruit ripening is controlled, namely, alternative splicing, mRNA N6-methyladenosine RNA modification methylation, and noncoding RNAs at the posttranscriptional level; regulation of translation efficiency and upstream open reading frame-mediated translational repression at the translational level; and histone modifications, protein phosphorylation, and protein ubiquitination at the posttranslational level. Taken together, these posttranscriptional regulatory mechanisms, along with transcriptional regulation, constitute the molecular framework of fruit ripening. We also critically discuss the potential usage of some mechanisms to improve fruit traits.
Therapists’ experiences of remotely delivering cognitive-behavioural or graded-exercise interventions for fatigue: a qualitative evaluation
Authors: Bennett Sarah E , Almeida Celia , Bachmair Eva-Maria , Gray Stuart R , Lovell Karina , Paul Lorna , Wearden Alison , Macfarlane Gary J , Basu Neil , Dures Emma 
Published: October 2022

Abstract

Objective
Fatigue is a challenging feature of all inflammatory rheumatic diseases. LIFT (Lessening the Impact of Fatigue in inflammatory rheumatic diseases: a randomized Trial) included remotely delivered personalized exercise programme (PEP) or cognitive-behavioural approach (CBA) interventions. The aim of this nested qualitative evaluation was to understand rheumatology health professionals’ (therapists’) perspectives of delivering the interventions in the LIFT trial.

Methods
A subgroup of therapists who had delivered the personalized exercise programme (PEP) and cognitive-behavioural approach (CBA) interventions took part in semi-structured telephone interviews.

Results
Seventeen therapists (13 women and 4 men) who delivered PEP (n = 8) or CBA (n = 9) interventions participated. Five themes were identified. In ‘The benefits of informative, structured training’, therapists described how they were able to practice their skills, and the convenience of having the LIFT manual for reference. When ‘Getting into the swing of it’, supporting patients gave therapists the confidence to tailor the content of the manual to each patient. Clinical supervision supported therapists to gain feedback and request assistance when required. In ‘Delivering the intervention’, therapists reported that patients valued the opportunity to talk about their fatigue and challenge their beliefs. In ‘Challenges in delivering the LIFT intervention’, therapists struggled to work in partnership with patients who lacked motivation or stopped engaging. Finally, in ‘LIFT developing clinical skills’, therapists gained confidence and professional satisfaction, seeing patients’ fatigue improve over time.

Conclusion
The findings support the provision of training for rheumatology health professionals to remotely deliver fatigue-management interventions. Insights from these trials can be used to better improve clinical practice and service provision.
Analyses of plasma inflammatory proteins reveal biomarkers predictive of subsequent development of giant cell arteritis: a prospective study
Authors: Wadström Karin , Jacobsson Lennart T H , Mohammad Aladdin J , Warrington Kenneth J , Matteson Eric L , Jakobsson Magnus E , Turesson Carl 
Published: October 2022

Abstract

Objective
To investigate the relation between biomarkers of inflammation and subsequent development of GCA.

Method
Participants in the population-based Malmö Diet Cancer Study (MDCS; N = 30 447), established 1991–96, who were subsequently diagnosed with GCA, were identified in a structured process. GCA-free controls, matched for sex, year of birth and year of screening were selected from the study cohort. Baseline plasma samples were analysed using the antibody-based OLINK proteomics inflammation panel (92 inflammatory proteins). Analyses were pre-designated as hypothesis-driven or hypothesis-generating. In the latter, principal component analysis was used to identify groups of proteins that explain the variance in the proteome. Within components selected based on eigenvalues, proteins with a factor loading of &gt;0.50 were investigated.

Results
Ninety-four cases with a confirmed incident diagnosis of GCA (median 11.9 years after inclusion) were identified. Among biomarkers with a priori hypotheses, IFN-γ was positively associated with GCA [odds ratio (OR) per s.d. 1.52; 95% CI 1.00, 2.30]. Eight biomarkers in the hypothesis-generating analyses were significantly associated with development of GCA. Among these, higher levels of IFN-γ (OR 2.37; 95% CI 1.14, 4.92) and monocyte chemotactic protein 3 (MCP3) (OR 4.27; 95% CI 1.26, 14.53) were particularly associated with increased risk of GCA in the subset sampled &lt;8.5 years before diagnosis. Several other proteins known to be important for T cell function were also associated with GCA in these analyses, e.g. CXCL9, IL-2, CD40 and CCL25.

Conclusion
Elevated IFN-γ levels were found years prior to diagnosis of GCA. T cell activation may precede the clinical onset of GCA.
A variation on Empedocles’ Sphere—values, interests, knowledge and resource in strategic philanthropy and the impact of oscillating forces of harm and duty
Authors: McKay Jon 
Published: October 2022

Abstract
There are a variety of legal and technical considerations when establishing and maintaining philanthropic structures for internationally mobile individuals and their families. Alignment of structures with the philanthropist and their family requires an understanding of their values, interests, knowledge and resources. Borrowing from the Greek Philosopher and Poet, Empedocles, and passing via Sesame Street, set out below is a framework for practitioners and advisers to ensure that philanthropic action, philanthropist and structure are aligned from the outset and throughout irrespective of jurisdiction, philanthropic aims or motivations.
Molecular and functional characterization of an evolutionarily conserved CREB‐binding protein in the LymnaeaCNS
Authors: Hatakeyama Dai , Sunada Hiroshi , Totani Yuki , Watanabe Takayuki , Felletár Ildikó , Fitchett Adam , Eravci Murat , Anagnostopoulou Aikaterini , Miki Ryosuke , Okada Ayano , Abe Naoya , Kuzuhara Takashi , Kemenes Ildikó , Ito Etsuro , Kemenes György 
Published: October 2022

AbstractIn eukaryotes, CREB‐binding protein (CBP), a coactivator of CREB, functions both as a platform for recruiting other components of the transcriptional machinery and as a histone acetyltransferase (HAT) that alters chromatin structure. We previously showed that the transcriptional activity of cAMP‐responsive element binding protein (CREB) plays a crucial role in neuronal plasticity in the pond snail Lymnaea stagnalis. However, there is no information on the molecular structure and HAT activity of CBP in the Lymnaea central nervous system (CNS), hindering an investigation of its postulated role in long‐term memory (LTM). Here, we characterize the Lymnaea CBP (LymCBP) gene and identify a conserved domain of LymCBP as a functional HAT. Like CBPs of other species, LymCBP possesses functional domains, such as the KIX domain, which is essential for interaction with CREB and was shown to regulate LTM. In‐situ hybridization showed that the staining patterns of LymCBP mRNA in CNS are very similar to those of Lymnaea CREB1. A particularly strong LymCBP mRNA signal was observed in the cerebral giant cell (CGC), an identified extrinsic modulatory interneuron of the feeding circuit, the key to both appetitive and aversive LTM for taste. Biochemical experiments using the recombinant protein of the LymCBP HAT domain showed that its enzymatic activity was blocked by classical HAT inhibitors. Preincubation of the CNS with such inhibitors blocked cAMP‐induced synaptic facilitation between the CGC and an identified follower motoneuron of the feeding system. Taken together, our findings suggest a role for the HAT activity of LymCBP in synaptic plasticity in the feeding circuitry.