bluuebunny/crossref_metadata_2025_split huggingface dataset:
Access to resources buffers against effects of current reproduction on future ability to provide care in a burying beetle
Authors: Lambert Georgia A. , Smiseth Per T. 
Published: September 2022

AbstractStudies investigating the trade‐off between current and future reproduction often find that increased allocation to current reproduction is associated with a reduction in the number or quality of future offspring. In species that provide parental care, this effect on future offspring may be mediated through a reduced future ability to provide care. Here, we test this idea in the burying beetle Nicrophorus vespilloides, a species in which parents shift the cost of reproduction toward future offspring and provide elaborate parental care. We manipulated brood size to alter the costs females experienced in association with current reproduction and measured the level of parental care during a subsequent breeding attempt. Given that these beetles breed on carcasses of small vertebrates, it is important to consider confounding effects due to benefits associated with resource access during breeding. We, therefore, manipulated access to carrion and measured the level of parental care during a subsequent breeding attempt. We found that females provided the same level of care regardless of previous brood size and resource access, suggesting that neither affected future ability to provide care. This may reflect that parents feed on carrion during breeding, which may buffer against any costs of previous breeding attempts. Our results show that increased allocation to current reproduction is not necessarily associated with a reduction in future ability to provide care. Nevertheless, this may reflect unique aspects of our study system, and we encourage future work on systems where parents do not have access to a rich resource during breeding.
Ligand‐Free Silver Nanoparticles for CO2 Electrocatalytic Reduction to CO
Authors: Mattarozzi Francesco , Visser Nienke , de Rijk Jan Willem , Ngene Peter , de Jongh Petra 
Published: September 2022

AbstractSilver‐based catalysts are attractive for electroreduction of CO2 to CO. To understand the electrocatalyst properties, a good control over the nanoparticle size is necessary. Herein, we report a strategy to synthesize highly dispersed, ligand‐free silver Ag nanoparticles supported on carbon. We demonstrate that the heat treatment atmosphere and carbon surface chemistry are crucial to control the Ag particle size in the 10–30 nm range. Even at low silver loadings (0.099 m2Ag m−2), Ag nanoparticles outperforms the bulk silver at low overpotentials, leading to a 23.5 % CO Faradaic efficiency at −1.2 V vs RHE. The Ag weight‐based activity of the catalysts scales with the inverse particle size, while the Ag surface‐specific activity is independent of the particle size in this range. The supported silver nanoparticles can produce a H2 to CO ratio of 2.9 to 1, interesting for further exploration of this type of catalysts for syngas synthesis.
Preparation and application of a surfactant‐modified Halloysite nanotubes for the adsorption of nitrates from aqueous solutions: Kinetic and equilibrium studies
Authors: Fizir Meriem , Richa Amina , Touil Sami , Benmokadem Yassmine , Boubekeur Khadidja , Hallal Bochra , Drici Habiba , Wei Liu 
Published: September 2022

AbstractThe current research proposes the hexadecyltrimethylammonium bromide‐modified Algerian halloysite nanotubes (HNTs‐CTAB) as adsorbent for nitrate ions removal from aqueous solution via electrostatic interactions. X‐ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), Fourier‐transform infrared spectroscopy (FT‐IR), and nitrogen adsorption–desorption analysis techniques have been used to characterize the prepared adsorbants. The different operating condition that may affect the adsorption of nitrate was carried out. HNTs and HNTs‐CTAB adsorption capacities are considerably pH dependent. The optimum conditions for maximum removal of nitrate from aqueous solution were as follows: adsorbent masse was 40 mg, initial pH was 4, temperature was 25°C, initial nitrate concentration of 100 mg/L and equilibrium time was 3 h. Under optimal value of process parameters, maximum NO3− adsorption capacity of 47.4 mg/g was obtained. Kinetic investigation confirmed that the nitrate adsorption on modified HNTs followed a pseudo‐second‐order with correlation coefficients greater than 0.98 (R2 = 0.9870) and that empirical Freundlich isotherm was best fitted nitrate equilibrium adsorption. The thermodynamic studies indicated that the adsorption of nitrate onto HNTs‐CTAB is endothermic and spontaneous. HNTs‐CTAB displayed high regeneration ability by retaining a capacity above 40 mg/g after four reuse cycles. HNTs‐CTAB containing plentiful nitrate could be returned to the soil directly as an economic slow release fertilizers or a soil amendment due to its environmental‐friendly performance. Therefore, HNTs‐CTAB used for remediation of wastewater might be employed easily as farmland fertilizer.
Construction of hybrid 1D‐0D networks for efficient and accurate blood flow simulations
Authors: Ghitti Beatrice , Blanco Pablo J. , Toro Eleuterio F. , Müller Lucas O. 
Published: September 2022

AbstractThe one‐dimensional (1D) modeling of blood flow in complex networks of vessels and cardiovascular models can result in computationally expensive simulations. The complexity of such networks has significantly increased in the last years, in terms of both enhanced anatomical detail and modeling of physiological mechanisms and mechanical characteristics. To address such issue, the main goal of this work is to present a novel methodology to construct hybrid networks of coupled 1D and 0D vessels and to perform computationally efficient and accurate blood flow simulations in such networks. Departing from both the 1D and lumped‐parameter (0D) nonlinear models for blood flow, we propose high‐order numerical coupling strategies to solve the 1D, 0D, and hybrid coupling of vessels at junctions. To effectively construct hybrid networks, we explore different a‐priori model selection criteria focusing in obtaining the best possible trade‐off between computational cost of the simulations and accuracy of the computed solutions for the hybrid network with respect to the 1D network. The achievement of the expected order of accuracy is verified in several test cases. The novel methodology is applied to two different arterial networks, the 37‐artery network and the reduced ADAN56 model, where, in order to identify the best performinga‐priorimodel selection criteria, the quantitative assessment of CPU times and errors and the qualitative comparison between results are carried out and discussed.
Can we have a second helping? A preregistered direct replication study on the neurobiological mechanisms underlying self‐control
Authors: Scholz Christin , Chan Hang‐Yee , Poldrack Russell A. , de Ridder Denise T. D. , Smidts Ale , van der Laan Laura Nynke 
Published: September 2022

AbstractSelf‐control is of vital importance for human wellbeing. Hare et al. (2009) were among the first to provide empirical evidence on the neural correlates of self‐control. This seminal study profoundly impacted theory and empirical work across multiple fields. To solidify the empirical evidence supporting self‐control theory, we conducted a preregistered replication of this work. Further, we tested the robustness of the findings across analytic strategies. Participants underwent functional magnetic resonance imaging while rating 50 food items on healthiness and tastiness and making choices about food consumption. We closely replicated the original analysis pipeline and supplemented it with additional exploratory analyses to follow‐up on unexpected findings and to test the sensitivity of results to key analytical choices. Our replication data provide support for the notion that decisions are associated with a value signal in ventromedial prefrontal cortex (vmPFC), which integrates relevant choice attributes to inform a final decision. We found that vmPFC activity was correlated with goal values regardless of the amount of self‐control and it correlated with both taste and health in self‐controllers but only taste in non‐self‐controllers. We did not find strong support for the hypothesized role of left dorsolateral prefrontal cortex (dlPFC) in self‐control. The absence of statistically significant group differences in dlPFC activity during successful self‐control in our sample contrasts with the notion that dlPFC involvement is required in order to effectively integrate longer‐term goals into subjective value judgments. Exploratory analyses highlight the sensitivity of results (in terms of effect size) to the analytical strategy, for instance, concerning the approach to region‐of‐interest analysis.
Characteristics and clinical outcomes of patients with ALK‐positive anaplastic large cell lymphoma: Report from the prospective international T‐cell lymphoma project
Authors: Chiattone Carlos , Civallero Monica , Fischer Thais , Miranda Eliana , Manni Martina , Zing Natalia P. C. , Pileri Stefano A. , Montoto Silvia , Horwitz Steven M. , Cabrera Maria Elena , De Souza Carmino A. , Nagler Arnon , Luminari Stefano , Ferreri Andrés J. M. , Carson Kenneth R. , Re Alessandro , Rigacci Luigi , Nassi Luca , Stepanishyna Yana , Federico Massimo , Inghirami Giorgio 
Published: September 2022

AbstractThe T‐cell Lymphoma Project is an international registry prospective study that enrolled patients with newly diagnosed peripheral T‐cell and NK‐cell lymphomas (PTCL). The main objective was to define the clinical features and outcomes, establishing a robust benchmark for future clinical trials. Seventy‐four institutions from 14 countries in North America, South America, Europe, and Asia collected data on patients diagnosed and treated at their respective centers between September 2006 and February 2018. Among 1553 PTCL patients, 131 (8.4% of the total cohort) were confirmed to have anaplastic large cell lymphoma ‐ kinase positive (ALCL, ALK+). The median age of the patients was 39 years (18–84). Sixty‐five patients (66%) had advanced‐stage disease, although majority (45 patients, 54%) had a low‐risk International Prognostic Index (IPI) score (0–1). Of 97 patients treated with chemotherapy, 97% received anthracycline‐containing regimens. The overall response rate was 81%, with 69 patients (70%) achieving complete remission. Estimated OS and PFS at 3 years were 77% (95% CI: 54%–99%) and 68% (95% CI: 46%–90%), respectively, and at 5 years were very similar, 77% of OS (95% CI: 62%–92%) and 64% of PFS (95% CI: 34%–94%). Multivariate analysis for PFS showed advanced stage (hazard ratios [HR]: 4.72, 95% CI: 1.43–23.9, p = 0.015), elevated lactate dehidrogenade (LDH) (HR 4.85; 95% CI: 1.73–13.60, p = 0.001), and Eastern Cooperative Oncology Group Performance Status scale (ECOG‐PS) ≥2 (HR: 5.25; 95% CI: 1.68–16.4, p = 0.024). For OS, elevated LDH (HR: 3.77; 95% CI: 1.98–14.17, p = 0.014) and ECOG‐PS ≥2 (HR: 4.59; 95% CI: 1.46–14.39, p = 0.004) were identified. In summary, although the outcome of ALK+ ALCL is superior to that of other PTCLs, it remains sufficiently favorable, given the young median age of the patients. Our results confirm the usefulness of both IPI and Prognostic Index for T‐cell Lymphoma (PIT) in identifying groups of patients with different outcomes.Clinical Trials ID: NCT01142674.
A pleiotropic variant in DNAJB4 is associated with multiple myeloma risk
Authors: Dicanio Marco , Giaccherini Matteo , Clay‐Gilmour Alyssa , Macauda Angelica , Sainz Juan , Machiela Mitchell J. , Rybicka‐Ramos Malwina , Norman Aaron D. , Tyczyńska Agata , Chanock Stephen J. , Barington Torben , Kumar Shaji K. , Bhatti Parveen , Cozen Wendy , Brown Elizabeth E. , Suska Anna , Haastrup Eva K. , Orlowski Robert Z. , Dudziński Marek , Garcia‐Sanz Ramon , Kruszewski Marcin , Martinez‐Lopez Joaquin , Beider Katia , Iskierka‐Jazdzewska Elżbieta , Pelosini Matteo , Berndt Sonja I. , Raźny Małgorzata , Jamroziak Krzysztof , Rajkumar S. Vincent , Jurczyszyn Artur , Vangsted Annette Juul , Collado Pilar Garrido , Vogel Ulla , Hofmann Jonathan N. , Petrini Mario , Butrym Aleksandra , Slager Susan L. , Ziv Elad , Subocz Edyta , Giles Graham G. , Andersen Niels Frost , Mazur Grzegorz , Watek Marzena , Lesueur Fabienne , Hildebrandt Michelle A. T. , Zawirska Daria , Ebbesen Lene Hyldahl , Marques Herlander , Gemignani Federica , Dumontet Charles , Várkonyi Judit , Buda Gabriele , Nagler Arnon , Druzd‐Sitek Agnieszka , Wu Xifeng , Kadar Katalin , Camp Nicola J. , Grzasko Norbert , Waller Rosalie G. , Vachon Celine , Canzian Federico , Campa Daniele 
Published: September 2022

AbstractPleiotropy, which consists of a single gene or allelic variant affecting multiple unrelated traits, is common across cancers, with evidence for genome‐wide significant loci shared across cancer and noncancer traits. This feature is particularly relevant in multiple myeloma (MM) because several susceptibility loci that have been identified to date are pleiotropic. Therefore, the aim of this study was to identify novel pleiotropic variants involved in MM risk using 28 684 independent single nucleotide polymorphisms (SNPs) from GWAS Catalog that reached a significant association (P < 5 × 10−8) with their respective trait. The selected SNPs were analyzed in 2434 MM cases and 3446 controls from the International Lymphoma Epidemiology Consortium (InterLymph). The 10 SNPs showing the strongest associations with MM risk in InterLymph were selected for replication in an independent set of 1955 MM cases and 1549 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium and 418 MM cases and 147 282 controls from the FinnGen project. The combined analysis of the three studies identified an association between DNAJB4‐rs34517439‐A and an increased risk of developing MM (OR = 1.22, 95%CI 1.13‐1.32, P = 4.81 × 10−7). rs34517439‐A is associated with a modified expression of the FUBP1 gene, which encodes a multifunctional DNA and RNA‐binding protein that it was observed to influence the regulation of various genes involved in cell cycle regulation, among which various oncogenes and oncosuppressors. In conclusion, with a pleiotropic scan approach we identified DNAJB4‐rs34517439 as a potentially novel MM risk locus.
Detection and classification of large bowel obstruction from X‐ray images using machine learning algorithms
Authors: Tamyalew Yibeltal , Salau Ayodeji Olalekan , Ayalew Aleka Melese 
Published: September 2022

AbstractLarge bowel obstruction (LBO) occurs when there is a blockage or twisting in the large bowel that prevents wastes and gas from passing through. If left untreated, the blockage cuts off blood supply to the colon, causing sections of it to die which results in high rates of morbidity and fatality. The examination of clinical symptoms of LBO involves careful inspection of the cecum and colon. Radiologists use X‐rays to inspect the clinical signs. Some research has been done to automate the detection of related abdominal and intestinal diseases. However, all these studies concentrate only on detecting Crohn's, ulcerative colitis, Acute Appendicitis, colorectal cancer, celiac diseases, liver diseases, and chronic kidney diseases. Automatic detection and classification of LBO has not been given due attention so far to the best of the authors knowledge. To address this challenge, we have designed a model for the detection and classification of LBO. The models development comprises of stages such as preprocessing, detection, segmentation, feature extraction, and classification. We used YOLOv3 for detection and used a gray scale level co‐occurrence matrix (GLCM), and a convolutional neural network for feature extraction, while support vector machine (SVM) and softmax were used for classification. The proposed model achieved a diagnostic accuracy of 89% when feature extraction methods such as CNN and median filter with softmax classifier were used. CNN and Gaussian filter with soft max classifier achieved 91%, while CNN and anisotropic filter with soft max classifier achieved 92%. GLCM with threshold segmentation and Gaussian filter with SVM classifier achieved 87%, while CNN with watershed segmentation and Gaussian filter with SVM classifier achieved 97% and CNN‐GLCM with watershed segmentation and anisotropic diffusion filter with SVM classifier achieved 98% for detection and classification of LBO. Finally, this paper presented a performance analysis of various machine learning approaches for detection and classification of LBO. Hence, our model is designed to assist human experts (Radiologists) in diagnosing LBO.
Approach to the anorexic rabbit
Authors: Pellett Sarah , Hinde Jo 
Published: September 2022

Background: An anorexic rabbit is a common presentation to a veterinary practice and it's vital to remember that anorexia is not a single syndrome but can occur because of multifactorial conditions that often cause pain. Rabbits are prey species and hide clinical signs, so when they present to the clinic, the disease process is often advanced. Anorexia is one sign that may be seen with rabbit gastrointestinal syndrome, and other clinical signs include abdominal pain/distension, lethargy and lack of faecal output. Pain is associated with these signs and must be effectively addressed, in addition to the underlying cause. Anorexia may be a sign of other diseases such as upper respiratory tract disease, urogenital disease or dental disease.Aim of the article: This article outlines the approach to the anorexic rabbit, highlighting the main differential diagnoses for the underlying causes of anorexia, and discusses how to provide supportive care and the treatment options available.
Three‐dimensional ultrasound virtual organ computer‐aided analysis to monitor fetal intracranial volume development characteristics: A multi‐center study in a Chinese population
Authors: He HuiQin , Shu Shuang , Lan WenLi , Peng Cui , Ma MingXia , Li KaiShu 
Published: September 2022

AbstractObjectivesThis study aimed to evaluate the feasibility of monitoring fetal intracranial volume using three‐dimensional ultrasound virtual organ computer‐aided analysis (VOCAL) technology and to analyze normal fetal brain growth.MethodsThis multi‐center prospective cross‐sectional study included 821 pregnant women (18–40 gestational weeks) divided into 23 groups according to gestational week. We used transabdominal three‐dimensional ultrasound VOCAL to monitor fetal intracranial volume; explore the correlation between intracranial volume and gestational age, biparietal diameter (BPD), and head circumference (HC); and analyze the proportion of brain weight to body weight.ResultsThe intracranial volume of normal fetuses conformed to the normal distribution, gradually increased with gestational age, and was highly correlated with gestational age (r = 0.977), BPD (r = 0.975), and HC (r = 0.953; p < 0.001). The median percentage of brain weight (BW) to estimated fetal weight (EFW) was between 13% and 21%, and the BW/EFW ratio showed a significant downward trend in the third trimester. The VOCAL technology monitored the fetal intracranial volume with good repeatability.ConclusionsVOCAL technology is feasible for monitoring the fetal intracranial volume, and the intracranial volume increases more than 10‐times in the second and third trimesters.
Next‐generation sequencing‐based analysis to assess the pattern of relapse in patients with Philadelphia‐positive acute lymphoblastic leukemia
Authors: Ahn Jae‐Sook , Kim TaeHyung , Jung Sung‐Hoon , Ahn Seo‐Yeon , Song Ga‐Young , Kim Mihee , Yang Deok‐Hwan , Lee Je‐Jung , Kim Mi Yeon , Moon Joon Ho , Zhang Zhaolei , Kim Hyeoung‐Joon , Kim Dennis Dong Hwan 
Published: September 2022

AbstractIn this study, we performed serial monitoring using targeted DNA sequencing to identify genetic alterations in adults with Philadelphia‐positive acute lymphoblastic leukemia (Ph‐ALL). Deep sequencing was performed by targeting the coding regions of 45 genes with recurrent driver mutations and 1129 single nucleotide polymorphism sites. Of the 43 patients that we examined, at least one case of genetic alterations was detected in 38 (88%) of the 43 patients at diagnosis (somatic mutations in 10 patients [23%] and copy number aberrations [CNA] in 36 patients [84%]). The most frequently detected CNA lesions were in IKZF1 (n = 25, 58%) and the most frequently mutated gene was SETD2 (n = 5). At least one genetic abnormality (loss, gain, or persistence) was observed in all the samples obtained at relapse that were available for analysis (n = 15), compared with the samples obtained at diagnosis (disappearance of any previously detected genetic alterations: 11 patients [73%]; new genetic abnormalities: nine patients [60%]; and persistent genetic abnormalities: eight patients [53%]]. The most frequently deleted lesions were in IKZF1 (n = 9, 60%), and the most frequently mutated gene was ABL1 (eight patients, 53%). Our data indicate that leukemic progression may be associated with complex genetic alterations in Ph‐ALL during the course of treatment.
An unusual case of hepatosplenic T‐cell lymphoma‐like unclassifiable T/NK‐cell lymphoma accompanied by acute myeloid leukemia
Authors: Lee Shin , Kito Yusuke , Fujita Kei , Wakayama Hiroto , Kimura Masaki , Kawashima Keisuke , Tabata Tetsuya , Yoshino Tadashi , Hara Takeshi , Tsurumi Hisashi 
Published: September 2022

AbstractWe describe a case of unclassifiable T/NK‐cell lymphoma with concomitant acute myeloid leukemia (AML). A 73‐year‐old Japanese man was diagnosed with AML by bone marrow smear, but the presence of splenomegaly and liver tumor was incompatible with AML. Splenectomy and hepatic resection were performed to resolve the thrombocytopenia and define the diagnosis. The pathological findings showed sinusoidal involvement of abnormal lymphoid cells that were CD3‐positive but negative for T‐cell receptor (TCR) rearrangement. Our case could not be categorized as hepatosplenic T‐cell lymphoma because of the lack of immunohistological expression of TCR, despite the clinical similarity.
Design, synthesis and biological activities of 1,2,4‐triazolo[1,5‐a]pyrimidine‐7‐amine derivatives bearing 1,2,4‐oxadiazole motif
Authors: Han Lin‐Ru , Cheng Long , Hu Dong‐Song , Chen Qing‐Wu , Han Liang , Xu Tian‐Ming , Liu Xing‐Hai , Wu Ning‐Jie 
Published: September 2022

AbstractPyrimidine is an important heterocyclic ring with various activities, which are widely used in the field of pesticides and medicines. In this paper, a series of 1,2,4‐triazolo[1,5‐a]pyrimidine‐7‐amine compounds (V1–V16) containing 1,2,4‐oxadiazole moiety were designed and synthesized. Their structures were confirmed by 1H NMR, 13C NMR, 19F NMR, and HRMS. The biological activity results showed that compounds V5, V6, V7, V9, V10, V12, and V13 possessed good activity against Mythimna separate at 500 ppm, while compound V4 exhibited moderate activity against Aphis medicagini at 500 ppm. Furthermore, compounds V1 and V3 displayed good fungicidal activity against Pseudoperonospora cubensis at 200 ppm.