bluuebunny/crossref_metadata_2025_split huggingface dataset:
The new mineral tomiolloite, Al12(Te4+O3)5[(SO3)0.5(SO4)0.5](OH)24: A unique microporous tellurite structure
Authors: Missen Owen P. , Mills Stuart J. , Rumsey Michael S. , Spratt John , Najorka Jens , Kampf Anthony R. , Thorne Brent 
Published: January 2022

Abstract
Tomiolloite (IMA2021-019) is a new aluminum tellurite sulfite-sulfate mineral discovered at the Bambolla mine, Moctezuma, Sonora, Mexico, a well-known tellurium (Te) mineral locality. Tomiolloite forms roughly spherical clusters of crystals comprised of very thin, needle-like crystals (1 μm diameter, ~40 μm length) around a core of small, stubbier, broken crystals. Tomiolloite is generally found growing on tellurite or quartz. The strongest powder X-ray diffraction lines are [dobs Å (Iobs) (hkl)]: 11.667 (89) (100), 8.240 (38) (101), 4.107 (29) (202,211,121), 3.223 (100) (203,302,130), and 2.905 (37) (213,123,222,400). The empirical formula of tomiolloite, as determined by electron microprobe analysis, is (Al10.64Te1.016+Fe0.313+Zn0.04)Σ12(Te5.004+Pb0.02)Σ5.02(S0.494+S0.496+Si0.02)Σ1.00O21.53[(OH)20.86Cl0.11]Σ20.97, which is simplified to the ideal formula Al12(Te4+O3)5[(SO3)0.5(SO4)0.5](OH)24. Significant Te6+ substitution for Al3+ is observed in tomiolloite, verified by X-ray photoelectron spectroscopy and crystal-structure analysis. The structure of tomiolloite was determined using synchrotron single-crystal X-ray diffraction, showing that tomiolloite is hexagonal and crystallizes in the space-group P63/m, with the unit-cell parameters a = 13.3360(19) Å, c = 11.604(2) Å, V = 1787.3(6) Å3, and Z = 2. Tomiolloite has a unique microporous framework structure, which bears a slight similarity to that of zemannite, but it has a much larger cavity diameter (8.85 Å). The framework is built from edge-sharing Mφ6 octahedra (M = Al3+ and Te6+), Te4+O3 trigonal pyramids, and Te4+O4 disphenoids. Mφ6 octahedra edge-share to form crankshaft-shaped chains along c, with Te4+On polyhedra filling notches in the crankshafts and providing linkages between adjacent chains. The framework has an overall positive charge, which is balanced by the presence of both sulfite (SO32−) trigonal pyramids and sulfate (SO42−) tetrahedra in the channels.
Evolución Disruptiva de las Microfinanzas en el Perú
Authors: Toledo Concha Emerson 
Published: January 2022

Las entidades especializadas en el otorgamiento de créditos a la micro y la pequeña empresa en el Perú, están orientadas a realizar cambios disruptivos y acelerados en sus procesos con el fin de generar eficiencia financiera en sus indicadores. Son conscientes, que se enfrentan a un verdadero tsunami de cambios en esta industria masiva, donde cada vez más, el desarrollo tecnológico, la transformación digital, el uso de la big data y de las herramientas analíticas, impulsan hacia un cambio revolucionario que tienen que hacer estas entidades para reinventarse y enfrentar los nuevos desafíos en un entorno mucho más competitivo, generado por la sobreoferta de instituciones microfinancieras y la entrada de nuevos “jugadores”, que ha llevado a reducciones de tasas de interés, a un aumento en las provisiones de créditos y aún, la mayoría de estas entidades tradicionales, no pueden controlar los costos operativos que por naturaleza son altos en este sector. Por lo tanto este trabajo muestra que el continuismo de los modelos que funcionaron al inicio pueden llegar a ser en el corto plazo, cuestionados o ser obsoletos en sus procesos y aplicaciones, por lo que, en base a este nuevo contexto puedan cambiar su enfoque de gestión y liderazgo.
Examining gender role attitude as a moderator of personality, social support, and childcare responsibilities in women’s work-life balance
Authors: Shaleh Abdul Rahman , Nuraini Putri 
Published: January 2022

The participation of women in the workforce creates challenges and problems. Those with various roles in their lives must be good at playing and balancing these successfully. This study focuses on the work-life balance factor by exploring the predictor factors including personality, family social support, and childcare responsibilities, as moderated by gender role attitude. A work/ nonwork interference and enhancement scale, mini-IPIP, gender role beliefs scale, and social support scale were developed for the data collection. A sample of 220 married female workers was identified using purposive sampling. The data analysis, which used multiple regression and a modgraph, shows a significant effect of personality, social support, and childcare responsibilities on the work-life balance moderated by gender role attitude. Four independent variables with significant influence are neuroticism, openness to experiencing family support, gender role attitude and there is a moderating effect on neuroticism and family support. The implication is the need to provide a comfortable work environment and arrangement of work patterns so that women's work-life balance can be achieved positively.
Molecules Containing Cyclobutyl Fragments as Therapeutic Tools: A
Review on Cyclobutyl Drugs
Authors: Ren Shuang , Pan Fei , Zhang Wen , Rao Guo-Wu 
Published: January 2022

Abstract:
In recent years, cyclobutyl has become more influential in the field of drug design.
Its unique four-membered ring structure is not only a useful intermediate for the
synthesis of biomedical candidate materials but also an indispensable framework for drug
design and application. According to the therapeutic field, cyclobutyl drugs are roughly
divided into tumor and cancer drugs, nervous system drugs, analgesics, antiviral drugs,
and gastrointestinal drugs. Among them, platinum-based anticancer drugs containing cyclobutyl
fragments have achieved remarkable success in the treatment of cancer, bringing
new hope for the development of more cyclobutyl drugs. This article provides details of
the research progress of the structure types, structure-activity relationships, targets, and
mechanisms of cyclobutyl drugs that have been on the market or are in the clinical stage
and provides ideas for the discovery and synthesis of novel cyclobutyl-containing drugs.
The Crosstalk between Gut Microbiota, Intestinal Immunological Niche and Visceral Adipose Tissue as a New Model for the Pathogenesis of Metabolic and Inflammatory Diseases: The Paradigm of Type 2 Diabetes Mellitus
Authors: Cianci Rossella , Franza Laura , Massaro Maria Grazia , Borriello Raffaele , Tota Antonio , Pallozzi Maria , De Vito Francesco , Gambassi Giovanni 
Published: January 2022

Abstract:Gut microbiota (GM) comprises more than one thousand microorganisms between bacterial species, viruses, fungi, and protozoa and represents the main actor of a wide net of molecular interactions, involving, among others, the endocrine system, immune responses, and metabolism. GM influences many endocrine functions, such as adrenal steroidogenesis, thyroid function, sexual hormones, IGF-1 pathway and peptides, produced in the gastrointestinal system. It is fundamental in glycaemic control and obesity, while also exerting an important function in modulating the immune system and associated inflammatory disease. The result of this crosstalk in gut mucosa is the formation of the intestinal immunological niche. Visceral adipose tissue (VAT) produces about 600 different peptides and it is involved in lipid and glucose metabolism, and some immune reactions, through several adipokines. GM and VAT interact in a bidirectional fashion: while gut dysbiosis can modify VAT adipokines and hormone secretion, VAT hyperplasia modifies GM composition. Acquired or genetic factors leading to gut dysbiosis or increasing VAT (i.e., Western diet) induce a pro-inflammatory condition, which plays a pivotal role in the development of dysmetabolic and immunologic conditions, such as diabetes mellitus. Diabetes is associated with specific patterns of GM alterations, an abundance or reduction of GM species involved in controlling mucosal barrier status, glycaemic levels and exerting a pro- or anti-inflammatory activity. All these factors could explain the higher incidence of several inflammatory conditions in Western countries; furthermore, besides the specific alterations observed in diabetes, this paradigm could represent a common pathway acting in many metabolic conditions and could pave the way to new, interesting therapeutic approaches.
Nanoparticle Mediated Gene Therapy: A Trailblazer Armament to
Fight CNS Disorders
Authors: Annu  , Rehman Saleha , Nabi Bushra , Sartaj Ali , Md Shadab , Sahoo PK , Baboota Sanjula , Ali Javed 
Published: January 2022

Abstract:
Central nervous system (CNS) disorders account for boundless socioeconomic
burdens with devastating effects among the population, especially the elderly. The major
symptoms of these disorders are neurodegeneration, neuroinflammation, and cognitive
dysfunction caused by inherited genetic mutations or by genetic and epigenetic changes
due to injury, environmental factors, and disease-related events. Currently available clinical
treatments for CNS diseases, i.e., Alzheimer’s disease, Parkinson’s disease, stroke,
and brain tumor, have significant side effects and are largely unable to halt the clinical
progression. So gene therapy displays a new paradigm in the treatment of these disorders
with some modalities, varying from the suppression of endogenous genes to the expression
of exogenous genes. Both viral and non-viral vectors are commonly used for gene
therapy. Viral vectors are quite effective but associated with severe side effects, like immunogenicity
and carcinogenicity, and poor target cell specificity. Thus, non-viral vectors,
mainly nanotherapeutics like nanoparticles (NPs), turn out to be a realistic approach
in gene therapy, achieving higher efficacy. NPs demonstrate a new avenue in pharmacotherapy
for the delivery of drugs or genes to their selective cells or tissue, thus providing
concentrated and constant drug delivery to targeted tissues, minimizing systemic
toxicity and side effects. The current review will emphasize the role of NPs in mediating
gene therapy for CNS disorders treatment. Moreover, the challenges and perspectives of
NPs in gene therapy will be summarized.
Eosinophils Restrict Diesel Exhaust Particles-induced Cell Proliferation of Lung Epithelial A549 Cells via Interleukin-13 Mediated Mechanisms: Implications for Tissue Remodeling and Fibrosis
Authors: Niranjan Rituraj , Muthukumaravel Subramanian , Panneer Devaraju , Ojha Sanjay Kumar 
Published: January 2022

Background:Diesel exhaust particles (DEPs) affect lung physiology and cause serious damage to the lungs. A number of studies demonstrated that eosinophils play a very important role in the development of tissue remodeling and fibrosis of the lungs. However, the exact mechanism of pathogenesis of tissue remodeling and fibrosis is not known.Methods:Both in vitro and in vivo models were used in the study. HL-60 and A549 cells were also utilized in the study. 8 to 12 weeks old BALB/c mice were used for the in vivo study. Cell viability by MTT assay and RNA isolation by tri reagent was accomplished. mRNA expression of inflammatory genes was accomplished by real-time PCR or qPCR. Immunohistochemistry was done to assess the localization and expressions of proteins. One-way ANOVA followed by a post hoc test was done for the statistical analysis. Graph-Pad prism 5 software was used for statistical analysis.Results:Altogether, we elucidated the mechanistic role of eosinophils and IL-13 in the DEP-triggered proliferation of lungs cells, thus providing an insight into the pathophysiology of tissue remodeling and fibrosis of lungs.Conclusion:Altogether, we elucidated, the mechanistic role of eosinophils and IL-13 in the DEP-triggered proliferation of lungs cells thus providing an inside in the pathophysiology of tissue remodelling and fibrosis of lungs.
Antinociceptive Effects of Aza-Bicyclic Isoxazoline-Acylhydrazone Derivatives
in Different Models of Nociception in Mice
Authors: Mota Fernanda Virginia Barreto , Coutinho Felipe Neves , de Carvalho Vanessa Mylenna Florêncio , de Assis Correia Julyanne Cunha , Bastos Isla Vanessa Gomes Alves , Marcelino-Neto Pedro Paulo , Ximenes Rafael Matos , Brondani Dalci José , de Faria Antônio Rodolfo , Marchand Pascal , da Silva Teresinha Gonçalves 
Published: January 2022

Background:
In a study recently published by our research group, the isoxazoline-acylhydrazone
derivatives R-99 and R-123 presented promising antinociceptive activity. However, the
mechanism of action of this compound is still unknown.

Objective:
This study aimed to assess the mechanisms involved in the antinociceptive activity of these
compounds in chemical models of pain.

Methods:
Animals were orally pretreated and evaluated in the acetic acid-, formalin-, capsaicin-,
carrageenan- and Complete Freund's Adjuvant (CFA)-induced pain models in mice. The effects of
the compounds after pretreatment with naloxone, prazosin, yohimbine, atropine, L-arginine, or
glibenclamide were studied, using the acetic acid-induced writhing test to verify the possible involvement
of opioid, α1-adrenergic, α2-adrenergic or cholinergic receptors, and nitric oxide or potassium
channels pathways, respectively.

Results:
R-99 and R-123 compounds showed significant antinociceptive activity on pain models induced
by acetic acid, formalin, and capsaicin. Both compounds decreased the mechanical hyperalgesia
induced by carrageenan or CFA in mice. The antinociceptive effects of R-99 and R-123 on
the acetic acid-induced writhing test were significantly attenuated by pretreatment with naloxone,
yohimbine or atropine. R-99 also showed an attenuated response after pretreatment with atropine
and glibenclamide. However, on the pretreatment with prazosin, there was no change in the animals'
response to both compounds.

Conclusion:
R-99 and R-123 showed antinociceptive effects related to mechanisms that involve, at
least in part, interaction with the opioid and adrenergic systems and TRPV1 pathways. The compound
R-99 also interacts with the cholinergic pathways and potassium channels.
Structural-activity Relationship of Metallo-aminoquines as Next
Generation Antimalarials
Authors: Abid Mohammad , Singh Shailja , Egan Timothy J. , Joshi Mukesh C. 
Published: January 2022

Abstract:
Apicomplexian parasite of the genus Plasmodium is the causative agent of malaria, one of
the most devastating, furious and common infectious disease throughout the world. According to the
latest World malaria report, there were 229 million cases of malaria in 2019 majorly consist of children
under 5 years of age. Some of known analogues viz. quinine, quinoline-containing compounds
have been used for last century in the clinical treatment of malaria. Past few decades witnessed the
emergence of multi-drug resistance (MDR) strains of Plasmodium species to existing antimalarials
pressing the need for new drug candidates. Thus, in those decades bioorganometallic approach to
malaria therapy has been introduced which led to the discovery of noval metalcontaining aminoquinolines
analogues viz. ferroquine (FQ or 1), Ruthenoquine (RQ or 2) and other related potent metalanalogues.
It observed that some metal containing analogues (Fe-, Rh-, Ru-, Re-, Au-, Zn-, Cr-, Pd-,
Sn-, Cd-, Ir-, Co-, Cu-, and Mn-aminoquines) were more potent; however, some were equally potent
as Chloroquine (CQ) and 1. This is probably due to the intertion of metals in the CQ via various approaches,
which might be a very attractive strategy to develop a SAR of novel metal containing antimalarials.
Thus, this review aim to summarize the SAR of metal containing aminoquines towards the
discovery of potent antimalarial hybrids to provide an insight for rational designs of more effective
and less toxic metal containing amonoquines.
Recent Developments of Coumarin-based Hybrids in Drug Discovery
Authors: Xia Dongguo , Liu Hao , Cheng Xiang , Maraswami Manikantha , Chen Yiting , Lv Xianhai 
Published: January 2022

Abstract:
Coumarin scaffold is a highly significant O-heterocycle, namely benzopyran-2-ones,
which form an elite class of naturally occurring compounds with promising therapeutic perspectives.
Based on its broad spectrum of biological activities, the privileged coumarin scaffold is applied
to medicinal and pharmacological treatments by several rational design strategies and approaches.
Structure-activity relationships of the coumarin-based hybrids with various bioactivity
fragments revealed significant information toward the further development of highly potent and selective
disorder therapeutic agents. The molecular docking studies between coumarins and critical
therapeutic enzymes demonstrated a mode of action by forming noncovalent interactions with
more than one receptor, further rationally confirming information about structure-activity relationships.
This review summarizes recent developments related to coumarin-based hybrids with other
pharmacophores aiming at numerous feasible therapeutic enzymatic targets in order to combat various
therapeutic fields, including anticancer, antimicrobic, anti-Alzheimer, anti-inflammatory activities.
COVID-19 Infection in Pregnancy: A Review
Authors: Mily Sabrina Jahan , Akter Kazi Mahmuda , Jabin Nowshin , Mitra Saikat , Emran Talha Bin , Nandi Monisha , Baral Sumit Kumar , Uddin Md. Zia , Mallick Jewel , Paul Arkajyoti , Shah Syed Uzair Ali , Rauf Abdur , Khan Ishaq N. , Mubarak Mohammad S. 
Published: January 2022

Abstract:
Coronavirus disease 2019 (COVID-19), which is a highly contagious viral illness caused by
the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a catastrophic effect on
the world's demographics, resulting in more than 3.8 million deaths worldwide and establishing itself as
the most serious global health crisis since the 1918 influenza pandemic. Several questions remain unanswered
regarding the effects of COVID-19 disease during pregnancy. Although most infections are mild
in high-risk populations, the severe disease frequently leads to intubation, intensive care unit admission,
and, in some cases, death. Hormonal and physiological changes in the immune and respiratory systems,
cardiovascular function, and coagulation may affect the progression of COVID-19 disease in pregnancy.
However, the consequences of coronavirus infection on implantation, fetal growth and development,
labor, and newborn health have yet to be determined, and, consequently, a coordinated global effort is
needed in this respect. Principles of management concerning COVID-19 in pregnancy include early
isolation, aggressive infection control procedures, oxygen therapy, avoidance of fluid overload, consideration
of empiric antibiotics (secondary to bacterial infection risk), laboratory testing for the virus and
co-infection, fetal and uterine contraction monitoring, prevention, and / or treatment of thromboembolism
early mechanical ventilation for progressive respiratory failure, individualized delivery planning,
and a team-based approach with multispecialty consultations. This review focuses on COVID-19 during
pregnancy, its management, and the area where further investigations are needed to reduce the risk to
mothers and their newborns.
Recent Advances in Combretastatin A-4 Inspired Inhibitors of Tubulin
Polymerization: An Update
Authors: Baytas Sultan Nacak 
Published: January 2022

Abstract:
Cancer is one of the leading causes of fatality and mortality worldwide. Investigations
on developing therapeutic strategies for cancer are supported throughout the
world. The massive achievements in molecular sciences involving biochemistry, molecular
chemistry, medicine, and pharmacy, and high throughput techniques such as genomics
and proteomics have helped create new potential drug targets for cancer treatment.
Microtubules are very attractive targets for cancer therapy because of the crucial
roles they play in cell division. In recent years, lots of efforts have been put into the identification
of new microtubule-targeting agents (MTAs) in anticancer therapy. Combretastatin
A-4 (CA-4) is a natural compound that binds to microtubules’ colchicine binding
site and inhibits microtubule polymerization. Due to CA-4’s structural simplicity, many
analogs have been synthesized. This article summarises the new molecule development
efforts to reach CA-4 analogues by pharmacophore group modifications, which have
been reported since 2015.
Self-Assessment of Biomedical Activity Related to Medical Devices Embedded in EMS Ambulances: Towards a Roadmap for an Efficient Improvement
Authors: Moussaid Abdelghani , Bouaouine Hassan , Ngote Nabil 
Published: January 2022

Objective:
The present investigation is focused on a self-assessment of the biomedical activity related to embedded Medical Devices on board a fleet of 46 EMS medicalized ambulances, according to the High Authority of Health standard (criterion 8K) and the Guide of the Good Practices of Biomedical Engineering.

Materials and Methods:
The methodology adopted for this purpose is based on an analysis allowing the evaluation and observation of practices related to biomedical activity in these ambulances. An initial assessment, carried out in March 2021, made it possible to measure the gaps between the actual situation and the recommendations of the two self-diagnosis tools (High Authority of Health and Guide of the Good Practices of Biomedical Engineering standards). A series of corrective actions were proposed and then implemented. A second self-assessment took place after 6 months, in October 2021.

Results:
Between March and October 2021, an improvement in the scores for almost all the axes of the two self-assessment tools was noted. Indeed, the score of the self-assessment for the High Authority of Health reference system rose from 44% in March 2021 to 63% in October 2021, i.e. an increase of 19%, and that of the Guide of the Good Practices of Biomedical Engineering increased from 67.54% in March 2021 to 80.96% in October 2021, i.e. an increase of 13.42%.

Conclusion:
The implementation of a maintenance strategy integrating the notion of quality, relevant procedures and pertinent work tools has made it possible to significantly improve the biomedical activity within the medical ambulances and to optimise the embedded medical devices.
Identifying the Most Successful Formula 1 Drivers in the Turbo Era
Authors: Piquero Alex R. , Piquero Nicole L. , Han Sungil 
Published: January 2022

Background:
Formula 1 is the world’s fastest auto racing circuit and one that is among the most-watched of all televised sports. With its international flair and glamor and the glitz it brings to viewers and spectators, it is no surprise that fans, commentators, and media covering the races enjoy ranking the most successful teams and especially the most successful drivers of all time. Yet, there are few empirical studies that have developed and/or applied rigorous methodological techniques to examine which drivers are the most successful within the recent turbo-hybrid era.

Objective:
This study uses novel group-based trajectory methods to rank the most successful drivers within the turbo area, 2014-2019.

Methods:
Group-based trajectory methods are used to identify distinct groups of drivers according to accumulated points.

Results:
Using total points accumulated during each respective season as our measure of success, results showed that the 45 drivers who competed during this time period could be classified into three groups, with the top-performing group of drivers being Lewis Hamilton and Nico Rosberg. A second better-performing group of six drivers followed and included Bottas, LeClerc, Räikkönen, Ricciardo, Verstappen, and Vettel. The remaining 37 drivers were classified into a third low-performing group, a great number of which scored zero points during the time period.

Conclusion:
The most successful Formula 1 drivers during the turbo era were able to be identified using group-based trajectory modeling, with Lewis Hamilton and Nico Rosberg identified as the best drivers based on accumulated points.