bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health‐Related Quality of Life in Pediatric Acute Recurrent or Chronic Pancreatitis
Authors: Tham See Wan , Wang Fuchenchu , Gariepy Cheryl E. , Cress Gretchen A. , Abu‐El‐Haija Maisam A. , Bellin Melena D. , Ellery Kate M. , Fishman Douglas S. , Gonska Tanja , Heyman Melvin B. , Lin Tom K. , Maqbool Asim , McFerron Brian A. , Morinville Veronique D. , Nathan Jaimie D. , Ooi Chee Y. , Perito Emily R. , Schwarzenberg Sarah Jane , Sellers Zachary M. , Shah Uzma , Troendle David M. , Wilschanski Michael , Zheng Yuhua , Yuan Ying , Lowe Mark E. , Uc Aliye , Palermo Tonya M. ,   INternational Study Group of Pediatric Pancreatitis: In search for a cuRE (INSPPIRE) and Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC)
Published: February 2022

ABSTRACTObjectives:Abdominal pain, emergency department visits, and hospitalizations impact lives of children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). Data on health‐related quality of life (HRQOL) in this population, however, remains limited. We aimed to evaluate HRQOL in children with ARP or CP; and test biopsychosocial risk factors associated with low HRQOL.Methods:Data were acquired from the INternational Study Group of Pediatric Pancreatitis: In search for a cuRE registry. Baseline demographic and clinical questionnaires, the Child Health Questionnaire (measures HRQOL) and Child Behavior Checklist (measures emotional and behavioral functioning) were completed at enrollment.Results:The sample included 368 children (54.3% girls, mean age = 12.7years, standard deviation [SD] = 3.3); 65.2% had ARP and 34.8% with CP. Low physical HRQOL (M = 38.5, SD = 16.0) was demonstrated while psychosocial HRQOL (M = 49.5, SD = 10.2) was in the normative range. Multivariate regression analysis revealed that clinical levels of emotional and behavioral problems (B = –10.28, P < 0.001), episodic and constant abdominal pain (B = 04.66, P = 0.03; B = –13.25, P < 0.001) were associated with low physical HRQOL, after accounting for ARP/CP status, age, sex, exocrine, and endocrine disease (F [9, 271] = 8.34, P < 0.001). Borderline and clinical levels of emotional and behavioral problems (B = –10.18, P < 0.001; B = –15.98, P < 0.001), and constant pain (B = –4.46, P < 0.001) were associated with low psychosocial HRQOL (F [9, 271] = 17.18, P < 0.001).Conclusions:Findings highlight the importance of assessing HRQOL and treating pain and psychosocial problems in this vulnerable group of children.
The Impact of Compliance During Exclusive Enteral Nutrition on Faecal Calprotectin in Children With Crohn Disease
Authors: Mckirdy Shona , Russell Richard K. , Svolos Vaios , Gkikas Konstantinos , Logan Michael , Hansen Richard , Gerasimidis Konstantinos 
Published: February 2022

ABSTRACTIt remains unclear whether suboptimal response to exclusive enteral nutrition (EEN) in some children with Crohn disease (CD) is explained by poor compliance. The present study measured faecal gluten immunogenic peptides (GIP), a biomarker of gluten intake, in 45 children (3– 17 years) with CD, and explored associations with faecal calprotectin (FC) levels at 33 and 54 days of EEN. FC decreased in patients with undetectable GIP at both 33 and 54 days of EEN (mean decrease, 33 days: −743 mg/kg, 54 days: –1043 mg/kg, P < 0.001) but not in patients who had detectable levels. At EEN completion, patients with undetectable GIP had a lower FC by 717 mg/kg compared with patients with a positive GIP result (P = 0.042) and demonstrated a greater decline from baseline FC (–69% vs +5%, P = 0.011). Poorer response to EEN is explained in part by diminished compliance. Faecal GIP might be useful as proxy biomarker of EEN compliance.
Acute and Posttraumatic Stress in Family Members of Children With a Prolonged Stay in a PICU: Secondary Analysis of a Randomized Trial
Authors: Erçin-Swearinger Hazal , Lindhorst Taryn , Curtis J. Randall , Starks Helene , Doorenbos Ardith Z. 
Published: February 2022

OBJECTIVES:
To identify the prevalence of screening criteria for acute and posttraumatic stress disorders (PTSDs) and stress symptoms among family members of children in the PICU for more than 8 days and examine risk factors for stress symptoms.

DESIGN:
Secondary analysis of data from a randomized trial of a palliative care intervention conducted between 2010 and 2014.

SETTING:
An urban pediatric hospital in Seattle, WA.

SUBJECTS:
The sample included 377 family members of 220 children.

INTERVENTIONS:
Family Communication Study.

MEASUREMENTS AND MAIN RESULTS:
Outcomes were symptom scores and diagnostic screening criteria for acute stress disorder (ASD) and PTSD. Predictors included demographic- and admission-related characteristics and hypothesized risk factors for developing stress-related mental health disorders. The mean score for acute stress symptoms during the ICU stay was 40.3 (sd = 13.8) and 59 family members in total met diagnostic screening criteria for ASD during hospitalization (15.6%). At 3-month follow-up, the mean score for posttraumatic stress symptoms was 30.8 (sd = 12.9) and 52 family members met diagnostic criteria for PTSD (13.8%). Factors associated with meeting ASD screening criteria were unplanned admission and poorer family relationships. Factors associated with PTSD symptoms and diagnosis were longer length of stay, meeting ASD criteria during admission, child’s death, and less perceived social support.

CONCLUSIONS:
Meeting screening criteria for PTSD was associated with demographic, length of stay, and family relationships among family members of seriously ill children. PTSD outcomes were higher among family members whose child died. This study helps identify risk factors that can be used to target needed psychosocial screening, monitoring and support during and following a prolonged PICU admission, as well as family-centered interventions and supportive bereavement intervention for the family members of a deceased child.
Review and Evaluation of mHealth Apps in Solid Organ Transplantation: Past, Present, and Future
Authors: Fleming James N. , Pollock McLean D. , Taber David J. , McGillicuddy John W. , Diamantidis Clarissa J. , Docherty Sharron L. , Chambers Eileen T. 
Published: February 2022

Background.
With the rapid and widespread expansion of smartphone availability and usage, mobile health (mHealth) has become a viable multipurpose treatment medium for the US healthcare system.

Methods.
The purpose of this review is to identify posttransplant mHealth applications that support patient self-management or a patient–provider relationship and aim to improve clinical outcomes. The interventions were then analyzed and evaluated to identify current gaps and future needs of mHealth apps in solid organ transplantation.

Results.
The authors found a nearly universal dichotomy between perceived utility and sustained use, with most studies demonstrating significant attrition during the course of the intervention. In addition, interoperability continues to be a challenge.

Conclusions.
The authors present potential methods for mitigating the identified barriers and gaps in mHealth apps for solid organ transplant recipients.
Overview of tau PET molecular imaging
Authors: Cassinelli Petersen Gabriel , Roytman Michelle , Chiang Gloria C. , Li Yi , Gordon Marc L. , Franceschi Ana M. 
Published: February 2022

Purpose of review
This article reviews tau PET imaging with an emphasis on first-generation and second-generation tau radiotracers and their application in neurodegenerative disorders, including Alzheimer's disease and non-Alzheimer's disease tauopathies.

Recent findings
Tau is a critical protein, abundant in neurons within the central nervous system, which plays an important role in maintaining microtubules by binding to tubulin in axons. In its abnormal hyperphosphorylated form, accumulation of tau has been linked to a variety of neurodegenerative disorders, collectively referred to as tauopathies, which include Alzheimer's disease and non-Alzheimer's disease tauopathies [e.g., corticobasal degeneration (CBD), argyrophilic grain disease, progressive supranuclear palsy (PSP), and Pick's disease]. A number of first-generation and second-generation tau PET radiotracers have been developed, including the first FDA-approved agent [18F]-flortaucipir, which allow for in-vivo molecular imaging of underlying histopathology antemortem, ultimately guiding disease staging and development of disease-modifying therapeutics.

Summary
Tau PET is an emerging imaging modality in the diagnosis and staging of tauopathies.
The effect of the degree and location of danger in traffic hazard perception: an ERP study
Authors: Li Haoze , Chang Ruosong , Sui Xue 
Published: February 2022

Objectives
The aim of this study is to explore the influence of the degree and location of the danger of traffic hazards on the neural reaction process.

Methods
26 automobile drivers were asked to look at the pictures and press buttons on the pictures unrelated to traffic. Electroencephalography responses to traffic-related images were recorded and analyzed.

Results
It was found that danger in the central visual region induced a larger amplitude of the N100 component than in the peripheral visual region and the trend of different hazard levels was consistent. The danger in the central visual area also induced a larger amplitude of the P200 component than in the peripheral vision area. In addition, when the danger appeared in the central visual area (0°), the P200 amplitude induced by the low-hazard situation was smaller than that of the high-hazard situation. When the danger appeared in the peripheral visual area (7°), the P200 amplitude induced by the low-hazard situation was larger than that of the high-hazard situation. Finally, the presence of danger evoked a larger amplitude of the P300 component in the peripheral visual area than in the central visual area and the P300 amplitude was larger in the low-hazard situation than in the high-hazard situation.

Conclusions
The results suggest that hazards are more easily processed in the central visual area during the early stage of automatic perception. In the later hazard evaluation stage, the hazard in the central visual area and the high-hazard situation were more easily processed.
Genome-wide association studies-supported rs12966547 variant of the long noncoding RNA LOC105372125 is significantly associated with susceptibility to schizophrenia and bipolar disorder in Han Chinese women
Authors: Zhao Zhi , Zhu Lulu , Wu Xulong , Chen Qiang , Xu Bingyi , Yang Jialei , Guo Xiaojing , Su Li 
Published: February 2022

Objective
Genome-wide association studies have found that rs12966547 polymorphism was associated with susceptibility to schizophrenia in European populations. Recent studies showed that a genetic overlap may exist in schizophrenia and bipolar disorder. Here, we analyzed the associations between LOC105372125 rs12966547 polymorphism and schizophrenia and bipolar disorder in the Han Chinese population.

Methods
Our study recruited 548 schizophrenia patients, 512 bipolar disorder patients, and 598 healthy controls. Genotyping of rs12966547 were performed using the Sequenom MassARRAY platform.

Results
A significant association between rs12966547 polymorphism and susceptibility to bipolar disorder was observed after adjusting for sex and age (additive model: P

adj
= 0.040, recessive model: P

adj
= 0.044). However, no significant association was found between rs12966547 polymorphism and schizophrenia risk (all P > 0.05). In the analysis of gender, rs12966547 polymorphism was significantly associated with bipolar disorder (additive model: P

adj
= 0.027) and schizophrenia (dominant model: P

adj
= 0.039) in women. However, no significant association was found between rs12966547 polymorphism and the risk of bipolar disorder or schizophrenia in men (all P
adj > 0.05).

Conclusions
Polymorphism of rs12966547 on the long noncoding RNA LOC10537215 are a shared genetic variant of schizophrenia and bipolar disorder in Han Chinese women.
Transcriptional background effects on a tumor driver gene in a transgenic medaka melanoma model
Authors: Abdulsahib Shahad , Boswell William , Boswell Mikki , Savage Markita , Schartl Manfred , Lu Yuan 
Published: February 2022

AbstractThe Xiphophorus melanoma receptor kinase gene, xmrk, is a bona fide oncogene driving melanocyte tumorigenesis of Xiphophorus fish. When ectopically expressed in medaka, it not only induces development of several pigment cell tumor types in different strains of medaka, but also induces different tumor types within the same animal, suggesting its oncogenic activity has a transcriptomic background effect. Although the central pathways that xmrk utilizes to lead to melanomagenesis are well documented, genes and genetic pathways that modulate the oncogenic effect, and alter the course of disease have not been studied so far. To understand how the genetic networks between different histocytes of xmrk-driven tumors are composed, we isolated two types of tumors, melanoma and xanthoerythrophoroma, from the same xmrk transgenic medaka individuals, established the transcriptional profiles of both xmrk-driven tumors, and compared (1) genes that are co-expressed with xmrk in both tumor types, and (2) differentially expressed genes and their associated molecular functions, between the two tumor types. Transcriptomic comparisons between the two tumor types show melanoma and xanthoerythrophoroma are characterized by transcriptional features representing varied functions, indicating distinct molecular interactions between the driving oncogene and the cell type-specific transcriptomes. Melanoma tumors exhibited gene signatures that are relevant to proliferation and invasion while xanthoerythrophoroma tumors are characterized by expression profiles related metabolism and DNA repair. We conclude the transcriptomic backgrounds, exemplified by cell-type specific genes that are downstream of xmrk effected signaling pathways, contribute the potential to change the course of tumor development and may affect overall tumor outcomes.
Influenza vaccination and single cell multiomics reveal sex dimorphic immune imprints of prior mild COVID-19
Authors: Sparks Rachel , Lau William W. , Liu Can , Han Kyu Lee , Vrindten Kiera L. , Sun Guangping , Cox Milann , Andrews Sarah F. , Bansal Neha , Failla Laura E. , Manischewitz Jody , Grubbs Gabrielle , King Lisa R. , Koroleva Galina , Leimenstoll Stephanie , Snow LaQuita ,   OP11 Clinical Staff, Chen Jinguo , Tang Juanjie , Mukherjee Amrita , Sellers Brian A. , Apps Richard , McDermott Adrian B. , Martins Andrew J. , Bloch Evan M. , Golding Hana , Khurana Surender , Tsang John S. 
Published: February 2022

AbstractViral infections can have profound and durable functional impacts on the immune system. There is an urgent need to characterize the long-term immune effects of SARS-CoV-2 infection given the persistence of symptoms in some individuals and the continued threat of novel variants. Here we use systems immunology, including longitudinal multimodal single cell analysis (surface proteins, transcriptome, and V(D)J sequences) from 33 previously healthy individuals after recovery from mild, non-hospitalized COVID-19 and 40 age- and sex-matched healthy controls with no history of COVID-19 to comparatively assess the post-infection immune status (mean: 151 days after diagnosis) and subsequent innate and adaptive responses to seasonal influenza vaccination. Identification of both sex-specific and -independent temporally stable changes, including signatures of T-cell activation and repression of innate defense/immune receptor genes (e.g., Toll-like receptors) in monocytes, suggest that mild COVID-19 can establish new post-recovery immunological set-points. COVID-19-recovered males had higher innate, influenza-specific plasmablast, and antibody responses after vaccination compared to healthy males and COVID-19-recovered females, partly attributable to elevated pre-vaccination frequencies of a GPR56 expressing CD8+ T-cell subset in male recoverees that are “poised” to produce higher levels of IFNγ upon inflammatory stimulation. Intriguingly, by day 1 post-vaccination in COVID-19-recovered subjects, the expression of the repressed genes in monocytes increased and moved towards the pre-vaccination baseline of healthy controls, suggesting that the acute inflammation induced by vaccination could partly reset the immune states established by mild COVID-19. Our study reveals sex-dimorphic immune imprints andin vivofunctional impacts of mild COVID-19 in humans, suggesting that prior COVID-19, and possibly respiratory viral infections in general, could change future responses to vaccination and in turn, vaccines could help reset the immune system after COVID-19, both in an antigen-agnostic manner.
Development of Parkinson’s disease and its relationship with incidentally-discovered white matter disease and covert brain infarction in a real world cohort
Authors: Kent David M. , Leung Lester Y. , Puttock Eric J. , Wang Andy Y. , Luetmer Patrick H. , Kallmes David F. , Nelson Jason , Fu Sunyang , Zheng Chengyi , Liu Hongfang , Noyce Alastair J. , Chen Wansu 
Published: February 2022

ABSTRACTImportanceWhile a link between cerebrovascular disease and cerebrovascular risk factors and subsequent development of Parkinson’s disease has been suggested, the association between covert cerebrovascular disease and subsequent Parkinson’s disease has not been rigorously examined.ObjectiveTo examine the relationship between covert cerebrovascular disease, comprised of covert brain infarction and white matter disease, discovered incidentally in routine care and subsequent Parkinson’s disease.DesignEnrollment in this observational cohort study occurred between 2009 and 2019.SettingKaiser Permanente Southern California health system.ParticipantsPatients were ≥50 years old and received neuroimaging for a non-stroke indication.ExposureIncidental covert brain infarction and white matter disease identified by natural language processing of neuroimaging reports. Natural language processing also classified white matter disease severity.Main OutcomesParkinson’s disease.Results230,062 patients were included with a total of 980,772 person-years of follow-up and a median follow-up time of 3.72 years. 1,941 cases of Parkinson’s disease were identified, with a median time-to-event of 2.35 (IQR 0.90 to 4.58) years. Covert cerebrovascular disease was identified in 70,592 (30.68%) patients, 10,622 (4.62%) with covert brain infarction and 65,814 (28.61%) with white matter disease. After adjustment for known risk factors, white matter disease was found to be associated with Parkinson’s disease, with an adjusted hazard ratio of 1.67 (1.44, 1.93) for patients <70 years and 1.33 (1.18, 1.50) for those ≥70 years. Greater severity of white matter disease was associated with an increased incidence of Parkinson’s disease per 1000 person-years, from 1.52 (1.43, 1.61) in patients without white matter disease to 4.90 (3.86, 6.13) in those with severe white matter disease. Findings were robust when more specific definitions of Parkinson’s disease were used. Covert brain infarction was not associated with Parkinson’s disease (adjusted hazard ratio=1.05 [0.88, 1.24]).Conclusions and RelevanceWhite matter disease was associated with subsequent Parkinson’s disease, an association strengthened with younger age and increased white matter disease severity. Covert brain infarction did not appear to be associated with subsequent Parkinson’s disease.
Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases
Authors: Fruergaard Marlene Uglebjerg , Fælled Nielsen Christine Juul , Kjeldsen Cecilia Rosada , Iversen Lars , Andersen Jacob Lauwring , Nissen Poul 
Published: February 2022

AbstractThe p90 ribosomal S6 kinases (RSKs) contain two distinct catalytic kinase domains, the N-terminal and C-terminal kinase domains (NTKD and CTKD, respectively). The activation of CTKD is regulated by phosphorylation by extracellular signal-regulated kinase (ERK1/2) and an autoinhibitory αL helix. Through a mutational seriesin vitroof the RSK CTKDs, we found a complex mechanism lifting autoinhibition that led us to design constitutively active RSK CTKDs. These are based on a phosphomimetic mutation and a C-terminal truncation (e.g. RSK2 T577E D694*) where a high activity in absence of ERK phosphorylation is obtained. Using these constructs, we characterize IC50values of ATP-competitive inhibitors and provide a setup for determining specificity constants (kinact/Ki) of covalent CTKD inhibitors.
Mesoamerican Nephropathy in Central Panama
Authors: Courville Karen , Bustamante Norman , Hurtado Bárbara , Pecchio Maydelin , Rodríguez Clarissa , Núñez-Samudio Virginia , Landires Iván 
Published: February 2022

AbstractBackgroundIn the last three decades, there has been an increase in the frequency of patients diagnosed with chronic kidney disease of nontraditional causes (CKDnt) in the Mesoamerican region. A region with an increased frequency of patients with chronic kidney disease (CKD) has been identified in central Panama. The present study aims to characterize the clinical presentation of patients with CKDnt in an understudied population of the central region of Panama and compare them with patients with traditional CKD (CKDt).MethodsA retrospective descriptive study was conducted in a nephrology reference hospital in the central provinces of Herrera and Los Santos, comparing a group of 15 patients with CKDnt to 91 patients with CKDt. Sociodemographic variables, personal history, laboratory parameters, and of renal ultrasound were compared.ResultsCKDnt is more common among relatively younger male patients who engage in strenuous work activities at high temperatures. CKDnt is not associated with type 2 diabetes mellitus or chronic hypertension, as it is the case in patients with CKDt. Renal atrophy and hyperuricemia are significant clinical markers of CKDnt.ConclusionTo our knowledge, this is the first study in Panama and one of the few in Central America and the world to address the clinical presentation of patients with CKDnt compared to patients with CKDt. Because CKDnt remains asymptomatic for a long time, early detection is important, and efforts should be directed at halting disease progression at an early stage. Current evidence can also inform policies addressing occupational and environmental risk factors associated with CKDnt.
At Least Three Doses of Leading Vaccines Essential for Neutralisation of SARS-CoV-2 Omicron Variant
Authors: Singanallur Nagendrakumar B , van Vuren Petrus Jansen , McAuley Alexander J , Bruce Matthew P , Kuiper Michael J , Gwini Stella M , Riddell Shane , Goldie Sarah , Drew Trevor W , Blasdell Kim R , Tachedjian Mary , Mangalaganesh Shruthi , Chahal Simran , Caly Leon , Druce Julian D , Juno Jennifer A , Kent Stephen J , Wheatley Adam K , Vasan Seshadri S 
Published: February 2022

AbstractPlasma samples taken at different time points from donors who received either AstraZeneca (Vaxzevria) or Pfizer (Comirnaty) or Moderna (Spikevax) coronavirus disease-19 (COVID-19) vaccine were assessed in virus neutralization assays against Delta and Omicron variants of concern and a reference isolate (VIC31). With the Pfizer vaccine there was 6-8-fold reduction in 50% neutralizing antibody titres (NT50) against Delta and VIC31 at 6 months compared to 2 weeks after the second dose; followed by 25-fold increase at 2 weeks after the third dose. Neutralisation of Omicron was only consistently observed 2 weeks after the third dose, with most samples having titres below the limit of detection at earlier timepoints. Moderna results were similar to Pfizer at 2 weeks after the second dose, while the titres for AstraZeneca samples derived from older donors were 7-fold lower against VIC31 and below the limit of detection against Delta and Omicron. Age and gender were not found to significantly impact our results. These findings indicate that vaccine matching may be needed, and that at least a third dose of these vaccines is necessary to generate sufficient neutralising antibodies against emerging variants of concern, especially Omicron, amidst the challenges of ensuring vaccine equity worldwide.