bluuebunny/crossref_metadata_2025_split huggingface dataset:
The problem of maintaining the quality of life of older people living in self-isolation
Authors: Tyukin O. A. , Lukyanova I. E. 
Published: February 2022

This article describes the main issues and problems that arise in the process of implementing long-term home care and maintaining the quality of life of elderly people who are in conditions of forced self-isolation. The aim of the work is to identify factors that have a negative impact on the provision of a decent quality of life by long-term home care professionals for the elderly in conditions of self-isolation. The research material was official statistics and the results of scientific research by Russian scientists. The main research methods used were the method of theoretical scientific analysis, the method of systematization, interpretation, and the method of generalization of the activities of medical and social services that provide long-term care for the elderly at home. The analysis showed that the forced self-isolation of the elderly, caused by the presence of acute respiratory viral infections, leads to a number of negative consequences, which together can worsen both the physical and mental state of a person, which ultimately will lead to a decrease in the quality of life. The result of this study was to identify such problems that exist in the practice of long-term care for older people who are in conditions of forced self-isolation, such as: the problem of quality control of services, imperfection of methods and technologies used to work with older people to ensure a decent quality of life in conditions of forced self-isolation and limited social contacts. Based on the results of the study, some measures have been proposed that will resolve the existing problems in a relatively short time.
The effect of new derivatives of 3-hydroxypyridine on the development of brain edema in bacterial purulent meningitis in experimental conditions
Authors: Agarkova A. A. , Pokrovsky M. V. , Kolesnichenko P. D. , Nesterov A. V. 
Published: February 2022

Bacterial purulent meningitis (BPM) is one of the most severe infectious and inflammatory diseases of the nervous system, which is characterized by high mortality and frequent development of residual neurological deficits. Edema and swelling of the brain is the most common cause of death in patients with neuroinfections. Most often, brain edema develops in pneumococcal meningitis (PM), which has the highest mortality rate among all bacterial meningitis. The aim of our work was to study the effect of new derivatives of 3-hydroxypyridine, 2-ethyl-6-methyl-3-hydroxypyridinium 2.6-dichlorophenyl (amino)phenylethanoic acid (EMHDA) and bis(2-ethyl-6-methyl-3-hydroxypyridinium) 2.6-dichlo-rophenyl (amino)phenylethanoic acid (B-EMHDA), on the degree of brain edema in the simulation of BPM in experimental conditions.Material and methods. BPM was modeled by injecting a suspension containing Streptococcus pneumoniae at a concentration of 5 x 109 CFU/ml into the subarachnoid space of the brain. The degree of severity of cerebral edema in rats was assessed by determining the content of total water, free and bound fractions in the brain tissue, as well as the hydration coefficient. The lower the hydration coefficient, the more pronounced the cerebral edema. Determination of the content of water fractions in brain tissue and blood was carried out by the thermogravimetric method.Results and discussion. 24 hours after the induction of meningitis, the free water content increases and the amount of bound water decreases. That testifies to the development of cerebral edema. Hydration coefficient in the group treated with EMHDA at a dose of 50 mg/kg, increased by 11.5 % relative to the control group; in the group receiving EMHDA at a dose of 25 mg/kg, increased by 15.3 % compared to the control group (p<0.05). Hydration coefficient in the group treated with B-EMHDA at a dose of 50 mg/kg, increased by 23 % relative to the control group; in the group receiving B-EMHDA at a dose of 25 mg/kg, increased by 26.9 % compared to the control group; and the group receiving B-EM-HDA at a dose of 12.5 mg/kg was 19.2 % higher relative to the control group (p<0.05).Conclusion. Brain edema is least pronounced when using B-EMHDA at all three studied dosages - 50, 25 and 12.5 mg/kg. Injection of EMHDA at doses of 50 mg/kg and 25 mg/kg also helped to reduce the degree of brain edema when modeling BPM in experimental conditions.
Features of autophagy in the cytoplasm of endotheliocytes of blood capillaries in severe burn septicotoxemia
Authors: Savchenko S. V. , Grebenshchikova A. S. , Bgatova N. P. , Taskaeva Yu. S. , Letyagin A. Yu. , Novoselov V. P. 
Published: February 2022

Burn injury and its consequences are an important medical and social problem, given the high mortality and disability rates. The leading cause of death in patients with extensive and deep burns is burn septicotoxemia.Material and methods. The material was the heart muscle of the anterior, posterior and lateral walls of the left ventricle of those who died from burn disease during septicotoxemia. The control group included cases of male mortality as a result of “acute coronary death”. The study of the ultrastructure of endotheliocytes of blood capillaries of the myocardium has been carried out.Results and discussion. Ultrastructural analysis of endotheliocytes of blood capillaries of the myocardium showed that in burn septicotoxemia, intracellular degradation processes are observed in the form of swelling of the cytoplasm and organelles, a decrease in the concentration of vesicular structures, as well as activation of autophagy due to the appearance of autophagosomes and autolysosomes in the cytoplasm. Activation of autophagy should be considered as a naturally developing compensatory reaction aimed at preserving the cellular pool of endotheliocytes of the blood capillaries of the myocardium in response to the alterative effect caused by burn septicotoxemia.Conclusion. The obtained data can serve as a justification for the manifestation of left ventricular contractile insufficiency, which is a consequence of endothelial dysfunction and microcirculatory disorders in the myocardium in burn septicotoxemia.
Pulmonary tuberculosis in clinical practice
Authors: Shubina A. T. , Borodulina E. A. , Gerasimov A. N. , Yakovleva E. V. 
Published: February 2022

Pulmonary tuberculosis has a lot of clinical manifestations, and it complicates the diagnosis of tuberculosis in the general clinical practice. We studied the clinical manifestations of tuberculosis detected in the pulmonary department and compared them with the significancy of diagnostic methods.Material and methods. People with a verified diagnosis of lung tuberculosis (n = 109) were examined using the GeneXpert MTB/RIF method if Ziehl Nielsen bacterioscopy has negative results or if there was no effect of treatment for two weeks.Results. All patients had complaints of both intoxication and bronchitis as with pneumonia on admission. Infiltrative tuberculosis (57.1 %; n = 68), disseminated tuberculosis (16.8 %; n = 20) were most often diagnosed. We looked for correlations between dyspnea and the prevalence of the process (p = 0.24), dyspnea with temperature (p = 0.24), the presence of pain in the chest (p = 0.405), the results of immunodiagnostics and sputum examination (p = 0.133). We found out that there are no such correlations in tuberculosis. The term for diagnosing tuberculosis was 7.97 ± 3.9 days in the presence of cough with sputum and 9.04 ± 4.3 days in the case of dry cough. The term for diagnosing tuberculosis was 12.31 ± 4.9 days in patients without cough. Mycobacterium tuberculosis was detected using GeneXpert MTB/RIF molecular genetic methods with nonproductive cough in 84.5 % (60 people out of 71), while in the first days of hospitalization in 46.6 % of patients (28 people out of 60, p < 0.001).Conclusion. It was found that the period of hospitalization is little related to the characteristics of patients and depends on organizational measures to identify mycobacterium tuberculosis. It is recommended to immediately apply the GeneXpert MTB/RIF method to patients with mild tuberculosis.
Comparative characteristics of the level of highly sensitive C-reactive protein in patients with systemic lupus erythematosus and rheumatoid arthritis
Authors: Akhverdyan Yu. R. , Zavodovsky B. V. , Polyakova Yu. V. , Seewordova L. E. , Papichev E. V. 
Published: February 2022

The aim of this work was to study the dependence of the concentration of C-reactive protein in the blood of patients on the severity of systemic lupus erythematosus (SLE). Material and methods. We examined 26 patients with SLE, the comparison group consisted of patients with rheumatoid arthritis (RA) (n = 88). Results. The hsCRP level was significantly higher in patients with a high degree of activity than in patients with minimal and moderate SLE activity (F = 4.409, p = 0.023). In addition, in patients with SLE, a significant direct correlation was found between hsCRP and ESR values (r = 0.409, p = 0.047), antinuclear factor (r = 0.389, p = 0.021), antibodies to double-stranded DNA (r = 0.226, p = 0.033), leukocytes in urine (r = 0.571, p = 0.002), microalbuminuria (r = 0.727, p = 0.017) AsAT (r = 0.428, p = 0.046), and inverse correlation – with the value of blood leukocytes (r = –0.662, p < 0.001). Conclusion. It was found that an increase in the levels of hsCRP in the sera of SLE patients is accompanied by an increase in the degree of disease activity, which indicates a direct correlation between the level of hsCRP and SLE activity. Consequently, the concentration of hsCRP reflects the acute phase response and the intensity of the inflammatory process in SLE.
The Study of Karst Desertification Maros Pangkep Based on Landsat 8 OLI Imagery
Authors: Budiyanto Eko , Purnomo Nugroho Hari , Muzayanah Muzayanah , Kurniawati Aida , Prasetyo Ketut , Maginta Nastiti Sigra Dewi 
Published: February 2022

<pre><em>This study aim</em><em>ed</em><em> to examine the spectral imagery </em><em>of </em><em>Landsat </em><em>8 OLI</em><em> </em><em> that</em><em> can determine the level of tropical karst desertification Maros Pangkep South Sulawesi. The study method is based on </em><em>the </em><em>characteristics </em><em>of </em><em>spectral imagery </em><em>of </em><em>Landsat </em><em>8 OLI</em><em>. Spectral characteristic analysis </em><em>was conducted</em><em> based on derivative index values</em><em> of </em><em>Landsat </em><em>8 OLI of </em><em>single-channel spectral values, index </em><em>spectral </em><em>values, maximum values, mean, minimal index, and spatial analysis. The results show</em><em>ed</em><em> that </em><em>spectral imagery of </em><em>Landsat </em><em>8 OLI</em><em> </em><em>can be used as</em><em> the</em><em> identifier of the </em><em>desertification process</em><em>,</em><em> </em><em>that is</em><em> in band 5 whose maximum value </em><em>is</em><em> indicate</em><em>d by</em><em> the spectral value of vegetation. The karst deser</em><em>t</em><em>ification </em><em>level</em><em> in the study area showed that 0.3% of the regions were strongly </em><em>desertified or 0,97 km<sup>2</sup> </em><em>, 4.1% of medium</em><em> desertified or 12,03 km<sup>2</sup></em><em>, 16.7% were mildly </em><em>desertified or 49,17 km<sup>2</sup></em><em>, and 78.9% were not </em><em>desertified or 232,57 km<sup>2</sup></em><em>.</em><em> </em><em>Observation results for image accuracy shows that </em><em>strongly desertified </em><em>areas of land use are mining and cement industries, the medium </em><em>desertified </em><em>areas are utilized for marble mining, the mildly </em><em>desertified </em><em>areas are utilized for agricultural land, and not </em><em>desertified </em><em>areas land are being utilized for tropical rain forest is still dense.</em><em></em></pre>
The Discrepancy in the Posterior Boundary of Necrotic Lesion Between Axial and Oblique Axial Slices of MRI in Patients with Osteonecrosis of the Femoral Head
Authors: Ikemura Satoshi , Motomura Goro , Kawano Koichiro , Hamai Satoshi , Fujii Masanori , Nakashima Yasuharu 
Published: February 2022

Background:
Little is known concerning differences in assessment of anteroposterior osteonecrotic lesion of the femoral head (ONFH) between the axial plane parallel to the body axis (axial) and the axial plane parallel to the femoral neck axis (oblique axial) using magnetic resonance imaging (MRI). This study aimed to compare the posterior boundary of necrotic lesions between the axial and oblique axial planes on MRI.

Methods:
This study retrospectively reviewed 120 consecutive hips in 71 patients (47 males and 24 females; mean age, 42 years) with ONFH, for which both axial and oblique axial MRI slices were available. The posterior boundaries of the necrotic lesions were calculated as the ratio of posterior intact circumference to anteroposterior circumference of the femoral head using mid-axial and mid-oblique axial MRI slices. The necrotic angles, calculated using the modified Kerboul method, were compared between cases with progression and nonprogression of collapse.

Results:
The mean posterior intact ratio in the axial slice was 49.2% (range, 8.6 to 85.1%), while that in the oblique axial slice was 33.5% (7.5 to 79.2%). The posterior intact ratio in the oblique axial slice significantly decreased compared to that in the axial slice (p < 0.0001). In cases with progression of collapse, the mean necrotic angle was significantly larger in the oblique axial slice than in the axial slice (p < 0.0001). The sensitivity and specificity of the necrotic angle with regard to the prognosis of the femoral head were both higher when using the oblique axial slice (sensitivity: 88.4%, specificity: 82.3%) than when using the axial slice (sensitivity: 85.1%, specificity: 62.0%). The posterior intact ratio at a mean of 6.8 mm superior to the mid-axial slice corresponded to that of the mid-oblique axial slice.

Conclusion:
Our findings suggest that the posterior boundaries of necrotic lesions differ between axial and oblique axial slices, and examination of the oblique axial MRI slice might be more suitable for predicting the prognosis of the femoral head.

Level of Evidence:
Diagnostic-Investigating a diagnostic test. Level IV (Case series)
Dormancy Breaking Treatments in Northern Wild Rice (Zizania palustris L.) Seed Suggest a Physiological Source of Dormancy
Authors: McGilp Lillian , Semington Aaron , Kimball Jennifer 
Published: February 2022

Abstract
Dormancy is a limiting factor for breeding in northern wild rice (NWR; Zizania palustris L). This study developed a dormancy curve and tested a combination of scarification and hormone treatments, across three timepoints, for their ability to break dormancy in NWR and produce viable seedlings and plants. A dormancy curve was established across 9 months post-harvest, which showed maximum germination (95 %) by 17 weeks post-harvest and high germination (≥81 %) through the rest of the testing period. Next, dormancy breaking treatments were tested. At 1 week post-harvest, few seeds germinated (≤ 15 %) across all treatment combinations. However, sulfuric acid increased germination shortly after harvest (5.8 %), compared to water (0.5 %) and NaClO (0 %) but resulted in stunted seedlings, all but one of which died shortly thereafter. At 7 weeks, sulfuric acid treated seeds did not result in significantly higher germination than water and maximum germination was still below 15%. By 11 weeks post-harvest, the water treatments had the highest germination and resulted in the most viable plants, indicating that dormancy had begun to break naturally and exceeded the effect of the other scarification treatments. Hormonal treatments had no significant effect on germination or seed viability and no strong conclusions could be drawn about their effect on seedling or plant health. Due to the inability of early germinated seed to consistently produce viable plants and the increase in germination following sufficient cold storage, it is likely that NWR seed has intermediate or deep physiological dormancy.
SMARCB1 regulates a TFCP2L1-MYC transcriptional switch promoting renal medullary carcinoma transformation and ferroptosis resistance
Authors: Vokshi Bujamin , Davidson Guillaume , Helleux Alexandra , Rippinger Marc , Haller Alexandre , Gantzer Justine , Baltzinger Philippe , Thouvenin Jonathan , Bouarich-Bourimi Rachida , Manriquez Valentina , Zaidi Sakina , Msaouel Pavlos , Su Xiaoping , Lang Hervé , Tricard Thibault , Lindner Véronique , Surdez Didier , Kurtz Jean-Emmanuel , BOURDEAUT Franck , Tannir Nizar , Davidson Irwin , Malouf Gabriel 
Published: February 2022

Abstract
Renal medullary carcinoma (RMC) is an aggressive tumour driven by bi-allelic loss of SMARCB1 and tightly associated with sickle cell trait. However, the cell-of-origin and oncogenic mechanism remain poorly understood. Using single-cell sequencing of human RMC, we defined transformation of thick ascending limb (TAL) cells into three RMC cell states along an epithelial-mesenchymal gradient by loss of renal epithelial transcription factors TFCP2L1, HOXB9 and MITF and gain of MYC and NFE2L2-associated oncogenic and ferroptosis resistance programs. We describe the molecular basis for this transcriptional switch that is reversed by SMARCB1 re-expression repressing the oncogenic and ferroptosis resistance programs leading to ferroptotic cell death. Ferroptosis resistance links TAL cell survival with the high extracellular medullar iron concentrations associated with sickle cell trait, an environment propitious to the mutagenic events associated with RMC development. This unique environment may explain why RMC is the only SMARCB1-deficient tumour arising from epithelial cells, differentiating RMC from rhabdoid tumours arising from neural crest cells.
Effectiveness of Hypnosis for the Prevention of Anxiety During Coronary Angiography (HYPCOR Study): a prospective randomized study
Authors: Vuillaume Laure Abensur , Gentilhomme Charles , Weber Sandrine , Msc Nadia Ouamara , Bayard Julien , Valla Mathieu , Khalife Khalife , Goetz Christophe , Guler Nazmine 
Published: February 2022

Abstract
Background – Coronary angiography is the gold standard for the diagnosis of coronary artery disease. This procedure is nevertheless a source of anxiety given the inconvenience caused by its invasiveness but also due to the consequences linked to the discovery of potential diseases.Aim - The aim of this study was to determine the effectiveness of hypnosis on reducing patient anxiety prior to coronary angiography.Methods – A total of 169 patients with non-urgent indications of coronary angiography and no history of prior coronary angiography were randomized to a hypnosis or control group. Patients in the hypnosis group underwent a hypnosis session with posthypnotic suggestions in self hypnosis, while those in the control group had a conversational interview with the hypnotherapist. The primary endpoint was the level of anxiety prior to the exam assessed by the Spielberger State-Trait Anxiety Inventory (STAI-Y A).Results - Performing a hypnosis session did not translate into a significant decrease in anxiety prior to the procedure. Age, trait anxiety, state anxiety the day before and belief that hypnosis works in general were associated with anxiety prior to the procedure. There was no adverse effect secondary to hypnosis. There was no statistically significant difference between the 2 groups for the occurrence of complications due to the procedure.Conclusion - In the present study, performing a hypnosis session upstream of a coronary angiography, did not reduce the state anxiety measured immediately before the intervention. In all cases, the hypnotic experience seems to be positive for the patient, which encourages further research efforts.Trial registration - The research protocol was registered on the ClinicalTrials.gov registry (NCT02818101; 29/06/2016) and with the ANSM (IDRCB 2016-A00205-46; 02/02/2016).
Association of Inferior Division MCA Stroke Location With Populations With Atrial Fibrillation Incidence
Authors: Kim Ganghyun , Vitti Emilia , Stockbridge Melissa D. , Hillis Argye E. , Faria Andreia V. 
Published: February 2022

Abstract
Background and Aim: Anatomical features of Middle Cerebral Artery (MCA) bifurcation favors larger emboli entering the inferior rather than superior division. As cardiac source emboli are on average larger than arterial source emboli, we hypothesize that patients with atrial fibrillation have infarcts that involve more temporal and parietal lobes than frontal lobes.Methods: From 1,849 patients admitted with evidence of acute or early subacute ischemic stroke on diffusion-weighted MRI (DWI), 482 affected exclusively the “lobar” MCA (sparing the lenticulostriates). They were classified as “frontal predominant” (n=105) or “temporoparietal predominant” (n=197) if at least 75% of the infarct affected the frontal lobe or the temporal and parietal lobes, respectively. Differences between stroke location (frontal or temporoparietal), sex, and race were analyzed by Chi-square test. Results: Men were more likely than women, and white people were more likely than black people to have temporoparietal strokes versus frontal strokes. Patients with confirmed diagnosis of atrial fibrillation have more temporoparietal strokes, compared to frontal strokes.Conclusion: MCA ischemic strokes occur more often in temporoparietal areas in men and in white patients, populations with known elevated incidence of atrial fibrillation. Patients with confirmed diagnosis of atrial fibrillation have more temporoparietal strokes, compared to frontal strokes. Results align with the hypothesis that large emboli (mostly from cardiac source) are more likely to cause temporoparietal strokes in the MCA territory, compared to frontal strokes. This association can help guide search for the most likely etiology of infarcts.
The changes of extrapyramidal network studied by Diffusion tensor imaging in WD patients after 5 years of copper excluding treatment
Authors: ZHOU Xiang-xue , QIN Hao-ling , LIAO Jian , XIAO Xia 
Published: February 2022

Abstract
Objective: To evaluate the changes of extrapyramidal network in Wilson disease (WD) patients after 5 years of copper excluding treatment using diffusion tensor imaging (DTI). Methods: 50 patients with WD, including 41 with cerebral type and 9 with hepatic type, and 10 age-matched healthy controls were enrolled. Neurological symptoms were scored using the modified Young Scale. Patients with cerebral type WD were divided into four subgroups: those with (1) hypokinesia, (2) parkinsonism, (3) mouth and throat dystonia, and (4) psychiatric symptoms. All study subjects underwent DTI of the brain. Five regions of interest (ROIs) were chosen. Fractional anisotropy (FA) and fiber volumes between ROIs were determined. After 5 years of copper excluding treatment, DTI review was performed.Results: After 5 years of copper excluding treatment, the volumes of fibers between the globus pallidus (GP) and the putamen (PU), the GP and the caudate nucleus (CA), the substantia nigra (SN)and the PU, the SN and the thalamus (TH), the PU and the TH, the TH and the CA, the TH and the cerebellum were also significantly higher in WD patients (P=0.013,0.040,0.037, 0.021,0.042, 0.038, 0.019). The volumes of fibers between the SN and the PU were higher in WD patients of group 3 after therapy (P=0.027). FA values of the fibers between the GP and the PU, the GP and the CA were significantly higher in WD patients of group 4 after therapy (P=0.026, 0.047). FA values of the fibers between the GP and the CA in WD patients with hepatic type were higher in WD patients after therapy (P=0.019).Conclusions: After the treatment with metal chelating agent, the damage of extrapyramidal neural network connection fibers in WD patients were repaired to a certain extent. Different types of WD patients have different responses to copper excluding treatment.