bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reactive oxygen species‐mediated oxidative stress accelerates glycolysis via activation of the CaMKKβ/AMPK pathway in the yak longissimus dorsi postmortem
Authors: Zhu Xijin , Kong Xiangying , Zang Lei , Sun Nan , Yu Qunli , Han Ling 
Published: August 2022

AbstractBACKGROUNDAdenosine monophosphate‐activated protein kinase (AMPK) is instrumental in the initiation of early postmortem glycolysis and the advent of pale, soft, and exudative (PSE) meat when cellular energy is altered. However, conflicting studies show that AMPK activation without corresponding energy level changes in PSE meat challenges this long‐held notion. Here, we examined the effects of reactive oxygen species (ROS)‐mediated oxidative stress on AMPK activation in the context of glycolysis, protein solubility, and water‐holding capacity (WHC) in the postmortem yak longissimus dorsi (LD) muscle. Further, we explored the mechanisms underlying these effects.RESULTSHydrogen peroxide (H2O2) significantly augmented the degree of oxidative stress, increasing the production of ROS and malondialdehyde excessive production and reducing the activity of the anti‐oxidants superoxide dismutase and glutathione peroxidase. In turn, oxidative stress dramatically promoted AMPK activation and glycolysis by increasing glycogen depletion and promoting hexokinase and phosphofructokinase activity. Subsequently, lactic acid accumulation increased, leading to a rapid decline in pH, which aggravated protein solubility degree and centrifugal loss in the early postmortem yak LD muscle. Importantly, these changes caused by oxidative stress were eliminated by the AMPK inhibitor. Mechanistically, oxidative stress elevated calcium ion (Ca2+) levels, which mobilized calcium/calmodulin‐dependent protein kinase β (CaMKKβ) and AMPK. Rescue experiments confirmed that the increases were attenuated using Ca2+ and CaMKKβ chelators, respectively.CONCLUSIONThese results indicated that oxidative stress caused by ROS hastened early‐stage postmortem glycolysis and reduced the WHC of yak meat. These effects were likely mediated by the alternative and energy‐independent CaMKKβ/AMPK signaling pathway. © 2022 Society of Chemical Industry.
Acute, Recurrent, and Chronic Laryngopharyngeal Reflux: The IFOS Classification
Authors: Lechien Jérôme R. , Lisan Quentin , Eckley Claudia A. , Hamdan Abdul‐Latif , Eun Young‐Gyu , Hans Stéphane , Saussez Sven , Akst Lee M. , Carroll Thomas L. 
Published: August 2022

ObjectiveTo investigate the clinical patterns and disease evolution of laryngopharyngeal reflux (LPR) patients.MethodsPatients with LPR diagnosed by hypopharyngeal‐esophageal impedance‐pH monitoring were prospectively followed in three medical centers. Symptoms and findings were assessed with reflux symptom score (RSS) and reflux sign assessment (RSA). Patients were treated with 3‐to 9‐month diet and combination of proton pump inhibitors, alginate or magaldrate. Patients were followed for 3 years to determine the clinical evolution of symptoms over time. LPR that did not recur was defined as acute. Recurrent LPR consisted of reflux with one or several recurrences yearly despite successful treatment. Chronic LPR was reflux with a chronic course of symptoms. Predictive indicators of clinical evolution were investigated.ResultsOne hundred forty patients and 82 healthy individuals completed the evaluations. Among patients, 41 (29.3%), 57 (40.7%), and 42 (30.0%) had acute, recurrent, or chronic LPR respectively. Baseline quality of life‐RSS (QoL‐RSS) and RSS total scores were significantly higher in chronic LPR patients. The post‐treatment decrease of QoL‐RSS and RSS of acute LPR patients were significantly faster as compared to recurrent and chronic patients. QoL‐RSS >5 reported adequate sensitivity (94.2) and specificity (75.3). QoL‐RSS thresholds defined acute (QoL‐RSS = 6–25), recurrent (QoL‐RSS = 26–38), and chronic (QoL‐RSS > 38) LPR.ConclusionBaseline QoL‐RSS may predict the clinical course of LPR patients: acute, recurrent, or chronic. A novel classification system that groups patients according to the longevity, severity, and therapeutic response of symptoms was proposed: the International Federation of Otorhinolaryngological Societies Classification of LPR.Level of Evidence3 Laryngoscope, 133:1073–1080, 2023
Seasonal hypoxia and temperature inversions in a tropical bay
Authors: Adelson Anne E. , Altieri Andrew H. , Boza Ximena , Collin Rachel , Davis Kristen A. , Gaul Alan , Giddings Sarah N. , Reed Victoria , Pawlak Geno 
Published: August 2022

AbstractDissolved oxygen (DO) is a critically important ecological variable, and the prevalence of marine hypoxia is expected to increase due to the combined effects of ocean warming and eutrophication. Thermal stress can co‐occur with hypoxia, especially in tropical systems, and can exacerbate its effects. We examine the physical processes that are important in regulating hypoxia and temperature inversions in Bahía Almirante, a semi‐enclosed tropical embayment on the Caribbean coast of Panama. A 10‐yr record of observations at 7 locations within Bahía Almirante reveals seasonal temperature inversions and hypoxia at depth that often co‐occur. These features are more severe and persistent in the back bay, though they occur throughout Bahía Almirante. DO reductions correspond to periods with high freshwater input, including direct precipitation, resulting in strong salinity stratification that isolates bottom waters, allowing biological oxygen demand to draw down DO. Evidence indicates that lateral advection can contribute to reoxygenation events, and the relationship between near bottom DO and bottom salinities in the mid bay and back bay is consistent with deep‐water renewal as the mechanism for bottom water ventilation. These hypoxia and temperature inversion events impact the biological communities of Bahía Almirante, and the physical dynamics that regulate these coincident and persistent stressors for marine organisms are likely present in other shallow, tropical estuaries.
Thermal Stability and Flame Retardancy of Epoxy Resin with DOPO‐Based Compound Containing Triazole and Hydroxyl Groups
Authors: Zhao Wen‐Hua , Wang Jing‐Wen , Zhuang Guo‐Chao , Liu Dong‐Yue , Sun Chuang‐Chuang 
Published: August 2022

AbstractA reactive flame retardant (DTP) is successfully synthesized and characterized, and then incorporated into epoxy resin (EP) as a co‐curing agent. The thermal stabilities and flame‐retardant properties of epoxy thermosets are evaluated. Compared to neat EP, the thermogravimetric analysis (TG) results show that the thermal decomposition rate of EP/DTP is reduced by 45% and the char yield at 750 °C is increased by 67%, when the addition amount of DTP is 12 wt%. In the cone calorimetry test (CCT), the values of the peak of heat release rate (pk‐HRR), total heat release (THR), total smoke produce (TSP), and average of effective heat combustion (av‐EHC) of EP‐DTP‐12 are exhibited a reduction of 36.6%, 26.4%, 40.5%, and 23.6% relative to neat EP, respectively. Meanwhile, the value of the limiting oxygen index (LOI) of EP/DTP‐12 can reach 34.83%, and 6 wt% or more loading of DTP make EP/DTP pass the V‐0 rating in the UL‐94 test. Moreover, the flame‐retardant mechanism is investigated by thermogravimetric analysis/infrared spectrometry (TG‐IR) and scanning electron microscopy (SEM), which can be summarized into two aspects: the quenching effect of phosphorus‐containing radicals and diluting effect of nonflammable gases in the gas phase, and the barrier effect of char layer in the condensed phase.
The effect of innovation efficiency management on performance: Differences according to organizational size
Authors: Rubio‐Picón Concepción , Velasco‐Morente Francisco , Ramos‐Hidalgo Encarnación , Agustí María A. 
Published: August 2022

AbstractThe efficiency associated with innovation has been a frequently considered element in the literature. However, the conceptualization of this efficiency and its management is an underexplored factor. We study the way in which the different elements that conform to this efficiency are managed over time. From a dynamic efficiency analysis using data envelope analysis (DEA) and the Malmquist productivity index, we evaluate changes in efficiency and if there are differences according to firm size. Our results confirm the relevance of size in the way that firms manage their innovation efficiency and how small firms differ from larger ones in terms of efficiency management.
A mixed method for 3D nonlinear elasticity using finite element exterior calculus
Authors: Dhas Bensingh , Nagaraja Jamun Kumar , Roy Debasish , Reddy Junuthula N. 
Published: August 2022

AbstractIn this study, a mixed finite element model for 3D nonlinear elasticity using a Hu–Washizu (HW) type variational principle is presented. This mixed variational principle takes the deformed configuration and sections from its cotangent bundle as the input arguments. The critical points of the proposed HW functional enforce compatibility of these sections with the configuration, in addition to mechanical equilibrium and constitutive relations. Using this variational principle we construct a mixed FE approximation that distinguishes a vector from a 1‐form, a feature not commonly found in FE approximations for nonlinear elasticity. This distinction plays a pivotal role in identifying suitable FE spaces for approximating the 1‐forms appearing in the variational principle. These discrete approximations are constructed using ideas borrowed from finite element exterior calculus, which are in turn used to construct a discrete approximation to our HW functional. The discrete equations describing mechanical equilibrium, compatibility, and constitutive rule, are obtained by seeking extremum of the discrete functional with respect to the respective degrees of freedom. The discrete extremum problem is then solved numerically; we use Newton's method for this purpose. This mixed FE technique is then applied to a few benchmark problems wherein conventional displacement based approximations encounter locking and checker boarding. These studies help establish that our mixed FE approximation, which requires no artificial stabilizing terms, is free of these numerical bottlenecks.
Oxford Food and Activity Behaviors 20‐item questionnaire to assess personal weight management strategies: Development and testing
Authors: Hartmann‐Boyce Jamie , Harmer Georgina , Hobson Alice , Bateman Paul A. , Tudor Kate , Aveyard Paul , Jebb Susan A. 
Published: August 2022

AbstractObjectiveThe aim of this study was to develop a shortened Oxford Food and Activity Behaviors (OxFAB) questionnaire to identify the cognitive and behavioral strategies used by individuals during weight‐management attempts.MethodsThis study reduced an existing 117‐item questionnaire (the original OxFAB questionnaire) through identifying clusters of techniques from the responses of 278 people living with obesity and, within those clusters, identifying the most representative question or questions. Questions were rephrased to cover multiple strategies at the domain level, with several alternative phrasings developed for new questions. Face validity was tested through think‐aloud interviews with 12 people living with obesity. Questions were rephrased accordingly and tested using test‐retest (n = 172). Prevalence‐ and bias‐adjusted κ (PABAK) were calculated, and questions with PABAK < 0.41 were rewritten and evaluated in a new test‐retest sample (n = 130).ResultsOxFAB20 consists of 20 questions covering diet, physical activity, and cognitive strategies for weight management. Test–retest resulted in a mean PABAK score of 0.56 (SD = 0.14). Questions were revised where appropriate. The questionnaire is available for use via a CC‐BY license.ConclusionsThe OxFAB20 questionnaire provides a practical tool for researchers to identify the cognitive and behavioral strategies used by individuals during attempts at weight control.
Impact of program characteristics on weight loss in adult behavioral weight management interventions: systematic review and component network meta‐analysis
Authors: Hartmann‐Boyce Jamie , Ordóñez‐Mena José M. , Theodoulou Annika , Butler Ailsa R. , Freeman Suzanne C. , Sutton Alex J. , Jebb Susan A. , Aveyard Paul 
Published: August 2022

AbstractObjectiveBehavioral weight management programs (BWMPs) for adults lead to greater weight loss at 12 months than minimal‐intervention control treatments. However, there is considerable heterogeneity in the content of BWMPs and outcomes of treatment. This study assessed the contribution of individual components of BWMPs, using Bayesian component network meta‐analysis.MethodsRandomized controlled trials of BWMPs in adults were identified (latest search: December 2019) and arms coded for presence or absence of 29 intervention components grouped by type, content, provider, mode of delivery, and intensity.ResultsA total of 169 studies (41 judged at high risk of bias) were included in the main analysis. Six components had effect estimates indicating clinically significant benefit and credible intervals (CrIs) excluding no difference: change in diet (mean difference [MD] = −1.84 kg, 95% CrI: −2.91 to −0.80); offering partial (MD = −2.12 kg, 95% CrI: −3.39 to −0.89) or total meal replacements (MD = −2.63 kg, 95% CrI: −4.58 to −0.73); delivery by a psychologist/counselor (MD = −1.45 kg, 95% CrI: −2.81 to −0.06) or dietitian (MD = −1.31 kg, 95% CrI: −2.40 to −0.24); and home setting (MD = −1.05 kg, 95% CrI: −2.02 to −0.09).ConclusionsFuture program development should consider including these components; other approaches continue to warrant evaluation of effectiveness.
Chiral Iodotriptycenes: Synthesis and Catalytic Applications
Authors: Khan Nasim , Itaya Katsunori , Wirth Thomas 
Published: August 2022

AbstractInvited for this month′s cover picture is the group of Thomas Wirth at Cardiff University (UK). The cover picture shows two structures of triptycenes. In each of these molecules all three aromatic rings are different with the rigid structure of the molecules making them chiral. The two sp3‐carbons shown in red and green are the stereocentres with defined configuration. These molecules contain the crucial iodine functionality which are utilised to generate hypervalent iodine(III)‐catalysts in situ. The authors acknowledge Dr. Yu Wang for the creation of the cover image. Read the full text of their Research Article at 10.1002/open.202200145.
Extrarenal Wilms tumor with hypertension and dilated cardiomyopathy in an infant: A report of an unusual case
Authors: Qu Yan‐ning , Wu Yu‐rui , Qu Dong , Ge Hai‐yan 
Published: August 2022

AbstractWhile Wilms tumors are the most frequently detected kidney cancer type in children, extrarenal Wilms tumors (ERWTs) remain rare. This report is the first to describe hypertension and dilated cardiomyopathy in a patient with an ERWT. A 6‐month‐old male infant presented with an abdominal mass and paroxysmal hypertension; echocardiography revealed dilated cardiomyopathy with an ejection fraction of 34%, as well as substantially increased plasma renin activity. Pathology yielded a definitive diagnosis of ERWT. Cardiac function and blood pressure gradually returned to normal after tumorectomy. The early diagnosis of such a tumor together with efficient oncologic treatment are vital to optimal patient outcomes.
Duration of the untreated period affects bone mineral density in psychiatric patients requiring long‐term hospitalization: A cross‐sectional study
Authors: Kaga Itsuka , Iwata Hiroyoshi , Tokushige Akihiro , Akata Takushiro , Ueda Shinichiro 
Published: August 2022

AbstractAimOsteoporosis and bone fractures occur often on psychiatric wards. Although recent studies showed that bone mineral density (BMD) decreases in psychiatric patients, many risk factors remain unknown. This study aimed to explore the risk factors for decreased BMD in long‐term psychiatric inpatients in a closed ward.MethodsA cross‐sectional study of psychiatric inpatients hospitalized for over 20 weeks was conducted. Patients were divided into three groups according to BMD: normal, osteopenia, and osteoporosis. Psychiatric symptoms were assessed using the Brief Psychiatric Rating Scale (BPRS). The relevant history of psychiatric diseases was collected, and biomarkers related to osteoporosis were measured. Univariable and multivariable ordinal logistic regression analyses were performed to identify variables significantly associated with BMD category. Additional analyses evaluated the associations between an identified clinical variable and biomarkers and psychiatric symptoms that may be related to osteoporosis.ResultsSeventy‐one patients (28 normal BMD, 17 osteopenia, and 26 osteoporosis) participated in the study. The multivariable ordinal logistic analysis showed that the duration of untreated psychosis (DUP) was a risk factor (odds ratio = 0.77, 95% confidence interval: 0.63–0.91, p = 0.006), adjusting for the major confounders of sex and age. Additional analysis showed significant differences in BPRS, BPRS Negative Symptom score, and the Cu/Zn ratio between the short‐DUP group (DUP ≤ 1 year) and the long‐DUP group (DUP > 1 year).ConclusionThe DUP may affect BMD in long‐term psychiatric inpatients, presumably partly through increased severity of negative symptoms and micronutrient abnormalities. Shortening the untreated period might reduce the risk of osteoporosis.
The status of implementation of photovoltaic systems and its influencing factors in European countries
Authors: Raghoebarsing Amrita , Farkas Istvan , Atsu Divine , Boddaert Simon , Moser David , Shirazi Elham , Reinders Angèle 
Published: August 2022

AbstractThis paper gives an overview of the status of implementation of photovoltaic (PV) systems among 34 member countries involved in the COST Action PEARL PV in the year 2018. Besides this, influencing factors that have an impact on the implementation of PV systems in each country have been assessed. The implementation of PV systems varies in European countries due to differences in solar irradiation and weather conditions, electricity consumption, national economic situation, and governmental approaches to promote PV. For this paper, data sets covering, among others, numbers installed PV systems, and the variables mentioned above, were collected, processed, and synchronized. Subsequently, relations between data were analyzed by geographic mapping and mutual correlations. The 34 countries evaluated produced together 120 TWh of PV electricity in 2018. It was notable that Germany produced the highest amount (45 TWh) and has the highest share (8.4%) of PV in its electricity generation. Weak correlations were found between the different variables and the gross domestic product, annual global irradiation, number of subsidy schemes, cumulative installed capacity, annual electricity generated by PV, the share of RE, and share of PV. Logically, as expected, strong correlations (R2 = 0.9) were found between the number of inhabitants and the annual electricity production and consumption. From our analysis, we conclude that four different groups of countries can be identified to categorize the usability of PV. One type covers countries with a significant unused PV potential while local–global irradiation is redundantly available, such as Turkey, Spain, Cyprus, Portugal, and Israel.
Proteomic analysis of the meristematic root zone in contrasting genotypes reveals new insights in drought tolerance in rice
Authors: Abdirad Somayeh , Wu Yunqi , Ghorbanzadeh Zahra , Tazangi Sara Esmaeili , Amirkhani Ardeshir , Fitzhenry Matthew J. , Kazemi Mehrbano , Ghaffari Mohammad Reza , Koobaz Parisa , Zeinalabedini Mehrshad , Habibpourmehraban Fatemeh , Masoomi‐Aladizgeh Farhad , Atwell Brian J. , Mirzaei Mehdi , Salekdeh Ghasem Hosseini , Haynes Paul A. 
Published: August 2022

AbstractDrought is responsible for major losses in rice production. Root tips contain meristematic and elongation zones that play major roles in determination of root traits and adaptive strategies to drought. In this study we analysed two contrasting genotypes of rice: IR64, a lowland, drought‐susceptible, and shallow‐rooting genotype; and Azucena, an upland, drought‐tolerant, and deep‐rooting genotype. Samples were collected of root tips of plants grown under control and water deficit stress conditions. Quantitative proteomics analysis resulted in the identification of 7294 proteins from the root tips of IR64 and 6307 proteins from Azucena. Data are available via ProteomeXchange with identifier PXD033343. Using a Partial Least Square Discriminant Analysis on 4170 differentially abundant proteins, 1138 statistically significant proteins across genotypes and conditions were detected. Twenty two enriched biological processes showing contrasting patterns between two genotypes in response to stress were detected through gene ontology enrichment analysis. This included identification of novel proteins involved in root elongation with specific expression patterns in Azucena, including four Expansins and seven Class III Peroxidases. We also detected an antioxidant network and a metallo‐sulfur cluster assembly machinery in Azucena, with roles in reactive oxygen species and iron homeostasis, and positive effects on root cell cycle, growth and elongation.
Surface modification of recycled polymers in comparison to virgin polymers using Ar/O2 plasma etching
Authors: Amberg Martin , Höhener Marion , Rupper Patrick , Hanselmann Barbara , Hufenus Rudolf , Lehner Sandro , Perret Edith , Hegemann Dirk 
Published: August 2022

AbstractLow‐pressure plasma etching of a recycled polyethylene terephthalate (PET) film is studied in comparison to virgin PET and polypropylene (PP) using a capacitively coupled radio frequency (RF) plasma reactor. Recycled polymers are distinguished by increased impurity content and weakened mechanical properties, both affecting plasma etching and adhesion processes. Mild plasma conditions have been selected to maintain the material bulk properties of the polymers. The etch rates and the morphology of the polymer samples were thus determined at floating potential compared with etching at the RF electrode for varying argon/oxygen gas mixtures, etching duration, and sample size. Thermoanalytical and X‐ray techniques were used to characterize the polymer before and after the plasma etching treatment. Finally, adhesive‐tape peel tests proved that excellent adhesion of silver coatings can also be achieved on a plasma‐treated recycled PET film.
Inheritance of dicamba‐resistance in allotetraploid Chenopodium album
Authors: Ghanizadeh Hossein , Harrington Kerry C , He Lulu , James Trevor K 
Published: August 2022

AbstractBACKGROUNDChenopodium album L. is a troublesome weed in spring‐planted crops, and different levels of ploidy have been documented for this weed species. A population of C. album has evolved resistance to dicamba. The level of ploidy and inheritance of dicamba resistance was studied in this population.RESULTSThe resistant and susceptible individuals of C. album were confirmed as tetraploid by flow cytometry. Pair‐crosses were made between ten resistant and susceptible individuals. Eight F1 individuals from five crosses were confirmed resistant after treating with dicamba at 400 g a.e. ha−1. These individuals were selfed, and the response of their progenies to dicamba was assessed in dose–response experiments, and the results confirmed the resistance trait was dominant. Furthermore, an analysis of the segregation patterns revealed that the segregation response of all F2 progenies fitted a 3:1 (resistant/susceptible) ratio when treated with dicamba at 200, 400 and 800 g a.e. ha−1, suggesting a single gene was responsible for dicamba resistance.CONCLUSIONSDicamba resistance in the studied tetraploid population of C. album is governed by a single dominant gene. This type of inheritance suggests that selection for dicamba resistance can occur readily. © 2022 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.