bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Control of the Coordination Chemistry for the Genesis of Heterogeneous Catalytically Active Sites in Oxidation Reactions**
Authors: Bisio Chiara , Carniato Fabio , Guidotti Matteo 
Published: August 2022

AbstractThis Review provides a summary of the use and the role of coordination complexes as precursors for the generation of heterogeneous catalysts for oxidation reactions of interest for fine chemical synthesis. Specific attention is paid to the comprehension of phenomena explaining the formation of active sites in heterogeneous catalysts. Different families of coordination precursors are considered. For each example, a brief critical description of the synthesis, characterization, and catalytic performance is reported. Special attention is paid to the chemical environment of the first coordination sphere of the active metal centre. The catalysts obtained by heterogenization, grafting, or anchoring of homogeneous catalysts can therefore exhibit enhanced catalytic performance by merging advantages of both homogeneous and heterogeneous systems. The deposition of coordination complexes over a preformed support is indeed a conceptually versatile strategy to design novel catalysts with tuned and controlled properties.
Deep‐Blue Electroluminescence of Perovskites with Reduced Dimensionality Achieved by Manipulating Adsorption‐Energy Differences
Authors: Dong Jianchao , Lu Feifei , Han Dongyuan , Wang Jie , Zang Ziang , Kong Lingmei , Zhang Yu , Ma Xue , Zhou Jianheng , Ji Huiyu , Yang Xuyong , Wang Ning 
Published: August 2022

AbstractThe lagging development of deep‐blue perovskite light‐emitting diodes (PeLEDs) heavily impedes their practical applications in full‐color display due to the absence of spectrally stable emitters and the mismatch of carrier injection capacity. Herein, we report highly efficient deep‐blue PeLEDs through a new chemical strategy that addresses the dilemma for simultaneously constant electroluminescence (EL) spectra and high‐purify phase in reduced‐dimensional perovskites. The success lies in the control of adsorption‐energy differences between phenylbutylamine (PBA) and ethylamine (EA) interacting with perovskites, which facilitates narrow n‐value distribution. This approach leads to an increased exciton binding energy and enhanced surface potential, hence improving radiative recombination. As a result, an external quantum efficiency of 4.62 % is achieved in PeLEDs with a stable EL peak at 457 nm, demonstrating the best reported result for deep‐blue PeLEDs so far.
Cooperative Surface Passivation and Hierarchical Structuring of Zeolite Beta Catalysts
Authors: Han Sungmin , Linares Noemi , Terlier Tanguy , Hoke Jeffrey B. , García Martínez Javier , Li Yuejin , Rimer Jeffrey D. 
Published: August 2022

AbstractWe report a method to prepare core–shell zeolite beta (*BEA) with an aluminous core and an epitaxial Si‐rich shell. This method capitalizes on the inherent defects in *BEA crystals to simultaneously passivate acid sites on external surfaces and increase intracrystalline mesoporosity through facile post‐hydrothermal synthesis modification in alkaline media. This process creates more hydrophobic materials by reducing silanol defects and enriching the shell in silica via a combination of dealumination and the relocation of silica from the core to the shell during intracrystalline mesopore formation. The catalytic consequences of *BEA core–shells relative to conventional analogues were tested using the biomass conversion of levulinic acid andn‐butanol ton‐butyl levulinate as a benchmark reaction. Our findings reveal that siliceous shells and intracrystalline mesopores synergistically enhance the performance of *BEA catalysts.
Near Infrared Light Induced Radical Polymerization in Water
Authors: Neidinger Philipp , Davis Joshua , Voll Dominik , Jaatinen Esa A. , Walden Sarah L. , Unterreiner Andreas N. , Barner‐Kowollik Christopher 
Published: August 2022

AbstractWe introduce a gold nanorod (AuNR) driven methodology to induce free radical polymerization in water with near infrared light (800 nm). The process exploits photothermal conversion in AuNR and subsequent heat transfer to a radical initiator (here azobisisobutyronitrile) for primary radical generation. A broad range of reaction conditions were investigated, demonstrating control over molecular weight and reaction conversion of dimethylacrylamide polymers, using nuclear magnetic resonance spectroscopy. We underpin our experimental data with finite element simulation of the spatio‐temporal temperature profile surrounding the AuNR directly after femtosecond laser pulse excitation. Critically, we evidence that polymerization can be induced through biological tissues given the enhanced penetration depth of the near infrared light. We submit that the presented initiation mechanism in aqueous systems holds promise for radical polymerization in biological environments, including cells.
Improving the Accuracy of Modelling CO2 Electroreduction on Copper Using Many‐Body Perturbation Theory
Authors: Wei Ziyang , Sautet Philippe 
Published: August 2022

AbstractCopper (Cu) remains the most important metal catalyst for the carbon dioxide reduction reaction (CO2RR) into C2 products. Due to limited evidence from in situ experiments, mechanistic studies are often performed in the framework of density functional theory (DFT), using functionals at the generalized gradient approximation (GGA) level, which have fundamental difficulties to correctly describe CO adsorption and surface stability. We employ the adiabatic connection fluctuation dissipation theorem within the random phase approximation (RPA), in combination with the linearized Poisson–Boltzmann equation to describe solvation effects, to investigate the mechanism of CO2RR on the Cu(100) facet. Qualitatively different from the DFT‐GGA results, RPA results propose the formation of *OCCHO as the potential determining step towards C2 products. The results suggest that it is important to use more accurate methods like RPA when modeling reactions involving multiple CO‐related species like CO2RR.
Dynamically vulcanized polylactic acid/natural rubber/waste rubber blends: Effect of the crosslinking agent on the morphology and tensile properties
Authors: Candau Nicolas , Albiter Noel León , Coll Pol Roura , Maspoch Maria Lluïsa 
Published: August 2022

AbstractPLA/natural rubber (NR)/wastes tire rubber (GTR) were dynamically vulcanizing using dicumyl peroxide (DCP). Swelling, dissolution, and electron microscopy revealed that the unvulcanized and weekly vulcanized blends (DCP < 3 wt%) show a continuous rubber phase while the highly vulcanized blends (DCP > 3 wt%) show co‐continuous rubber/PLA phase. In the latter blends, the tensile toughness (1.3 MJ m−3) and the tensile‐impact strength of the neat PLA (58 kJ m−2) were increased of a factor 12.5 and 8.3 respectively. Moreover, the appropriate crosslinking agent content (3–3.75 wt%) in the ternary blends allowed to reach same tensile toughness, impact strength, shape recovery and shape fixity as compared to their equivalent binary PLA/NR blends.
The celebrity as teaching object: Using Kanye West and Kim Kardashian to explain Freud
Authors: Reynoso Joseph S. 
Published: August 2022

AbstractThe author describes some obstacles encountered teaching undergraduates psychoanalytic theory. In academic environments that reflect a broader cultural skepticism, disinterest and animosity to analytic ideas, the author argues that it is imperative to develop and utilize teaching methods that have an experience‐near quality. Without clinical experience and perhaps hesitant to use their own personal lives for material, students may seemingly lack data to test out the explanatory value of analytic ideas. This essay illustrates one device the author developed of using students' “celebrity object” relationships to idiosyncratically cathected popular culture figures to allow for increased engagement with analytic ideas.
DNA Origami in the Quest for Membrane Piercing
Authors: Niranjan Dhanasekar Naresh , Thiyagarajan Durairaj , Bhatia Dhiraj 
Published: August 2022

AbstractThe tool kit for label‐free single‐molecule sensing, nucleic acid sequencing (DNA, RNA and protein) and other biotechnological applications has been significantly broadened due to the wide range of available nanopore‐based technologies. Currently, various sources of nanopores, including biological, fabricated solid‐state, hybrid and recently de novo chemically synthesized ion‐like channels have put in use for rapid single‐molecule sensing of biomolecules and other diagnostic applications. At length scales of hundreds of nanometers, DNA nanotechnology, particularly DNA origami‐based devices, enables the assembly of complex and dynamic 3‐dimensional nanostructures, including nanopores with precise control over the size/shape. DNA origami technology has enabled to construct nanopores by DNA alone or hybrid architects with solid‐state nanopore devices or nanocapillaries. In this review, we briefly discuss the nanopore technique that uses DNA nanotechnology to construct such individual pores in lipid‐based systems or coupled with other solid‐state devices, nanocapillaries for enhanced biosensing function. We summarize various DNA‐based design nanopores and explore the sensing properties of such DNA channels. Apart from DNA origami channels we also pointed the design principles of RNA nanopores for peptide sensing applications.
A Polyanionic Tartrate‐containing Temperature‐responsive Hydrogel
Authors: Loh Wei Wei , Huang Miao , Goh Leonard , Lim Chen Chuan , Goh Rubayn , Lin Qianyu , Guo Liangfeng , Loh Xian Jun , Lim Jason Y. C. 
Published: August 2022

AbstractThermogels, a class of hydrogels which show spontaneous sol‐gel phase transition when warmed, are an important class of soft biomaterials. To date, however, most amphiphilic polymers that are able to form thermogels in aqueous solution are uncharged, and the influence of ionisable groups on thermogelation are largely unknown. Herein, we report the first example of a polyanionic amphiphilic multi‐block copolymer, containing multiple pendant carboxylate groups, that can form transparent thermogels spontaneously when warmed up to physiological temperature. We demonstrate that introducing negative charges onto thermogelling polymers could significantly alter the properties of the micelles and thermogels formed. Furthermore, the polymer's polyanionic character provides new options for modulating the gel rheological properties, such as stiffness and gelation temperatures, through electrostatic interactions with different cations. We also demonstrated that the polyanionic thermogel allowed slower sustained release of a cationic model drug compound compared to an anionic one over 2 weeks. The findings from our study demonstrate exciting new possibilities for advanced biomedical applications using charged polyelectrolyte thermogel materials.
SbCl3 Initiated Aerobic Phosphorylation of sp3 C−H Bond: A Facile Approach to α‐Phosphorylated Tetrahydroisoquinolines
Authors: Li Yuemei , Zhang Shuwei , Ma Qiyuan , Ding Han , Sun Zheng , Yuan Yu , Jia Xiaodong 
Published: August 2022

AbstractAn aerobic phosphorylation of N‐aryltetrahydroisoquinolines was realized by SbCl3 initiated sp3 C−H bond functionalization, providing a series of α‐aminophosphonates in high yields. This work reveals that SbCl3/O2 is an efficient and facile catalyst system to enable the aerobic C−H functionalization, and antimony containing reagents might be potentially applied to more general transformations.
ITGA5 and ITGB1 contribute to Sorafenib resistance by promoting vasculogenic mimicry formation in hepatocellular carcinoma
Authors: Shi Ying , Shang Jin , Li Yan , Zhong Deyuan , Zhang Zilong , Yang Qinyan , Lai Chunyou , Feng Tianhang , Yao Yutong , Huang Xiaolun 
Published: August 2022

AbstractBackgroundHepatocellular carcinoma (HCC) is labeled with high mortality and tolerance to chemotherapy. Sorafenib has been the first‐line treatment option in HCC patients for past decades, while the therapeutic effect was limited in almost HCC patients.MethodsIn this study, we analyzed public omics data of HCC patients with different responses to Sorafenib treatment. To confirm the role of integrins A5 and B1 (ITGA5 and ITGB1) in Sorafenib resistance, we generated the Sorafenib‐resistant (Sor‐R) cell lines and cells overexpressing ITGA5 or ITGB1. Hypoxia level was measured using Hypoxy probe by flow cytometry, while vasculogenic mimicry was detected and quantified by CD31 and periodic acid schiff staining.ResultsHypoxia was upregulated in non‐responsive patients, accompanied with genes involved in encoding extracellular matrix components and angiogenesis such as ITGA5 and ITGB1. Sor‐R hepatoma cell lines were constructed to measure expression and role of candidate genes. ITGA5 and ITGB1 were augmented in Sor‐R cells. Upregulation of ITGA5 or ITGB1 reduced the sensitivity to Sorafenib in HepG2 and Huh7 cells, aggravated the hypoxic condition and resulted in formation of vascular mimicry.ConclusionsThese findings suggested that hypoxia associated vascular mimicry account for non‐response to Sorafenib treatment in HCC patients. ITGA5 and ITGB1 may serve as effective predictors of HCC patients' outcome after Sorafenib treatment, which also provides a new target for HCC patients resistant to Sorafenib.
Effect of social disparities on 10 year survival in pediatric patients with Wilms' tumor
Authors: Chalfant Victor , Riveros Carlos , Stec Andrew A. 
Published: August 2022

AbstractBackgroundTo stratify 10‐year survival outcomes by degree of social disparities in pediatric Wilms' tumor patients. We applied the Social Deprivation Index (SDI) to survival outcomes from the national SEER database to elucidate the effects of lower socioeconomics on cancer survival.MethodsA retrospective cohort study was performed using the national Surveillance, Epidemiology, and End Results (SEER) oncology registry from 1975 to 2016 based on county‐level data. Pediatric patients (<18 years old) with a diagnosis of WT (C64.9) and confirmed based on histology codes (8960/8963) were included. SDI scores were calculated for each patient and initially divided into quintiles. Patients were delineated into high‐risk (>60th percentile/more deprived) or low‐risk (<60th percentile/less deprived) groups. Statistics were assessed using Fisher's exact test, Student's t‐test, and Kaplan–Meier assessed survival differences with log‐rank test for trend.ResultsA total of 3406 patients were included with 1366 patients reported in the high‐risk group and 2040 patients in the low‐risk group. Quintile data demonstrated a stratification in survival based on socioeconomic status. Patients in more socially deprived counties were significantly (p = 0.035) more likely to have worse overall survival compared with those living in less deprived areas at 10‐year (87.3% vs 89.3%) follow‐up.Conclusions10‐year overall and cancer‐specific survival data for patients with Wilms' tumor stratify by socioeconomic lines. This represents an area that needs to be addressed in this pediatric oncologic population. Patients from more socially deprived areas have significantly worse 10‐year overall survival rates and noticeably different 10‐year cancer‐specific survival rates.
βIII‐tubulin suppression enhances the activity of Amuvatinib to inhibit cell proliferation in c‐Met positive non‐small cell lung cancer cells
Authors: Brayford Simon , Duly Alastair , Teo Wee Siang , Dwarte Tanya , Gonzales‐Aloy Estrella , Ma Zerong , McVeigh Laura , Failes Timothy W. , Arndt Greg M. , McCarroll Joshua A. , Kavallaris Maria 
Published: August 2022

AbstractNon‐Small Cell Lung Carcinoma (NSCLC) remains a leading cause of cancer death. Resistance to therapy is a significant problem, highlighting the need to find new ways of sensitising tumour cells to therapeutic agents. βIII‐tubulin is associated with aggressive tumours and chemotherapy resistance in a range of cancers including NSCLC. βIII‐tubulin expression has been shown to impact kinase signalling in NSCLC cells. Here, we sought to exploit this interaction by identifying co‐activity between βIII‐tubulin suppression and small‐molecule kinase inhibitors. To achieve this, a forced‐genetics approach combined with a high‐throughput drug screen was used. We show that activity of the multi‐kinase inhibitor Amuvatinib (MP‐470) is enhanced by βIII‐tubulin suppression in independent NSCLC cell lines. We also show that this compound significantly inhibits cell proliferation among βIII‐tubulin knockdown cells expressing the receptor tyrosine kinase c‐Met. Together, our results highlight that βIII‐tubulin suppression combined with targeting specific receptor tyrosine kinases may represent a novel therapeutic approach for otherwise difficult‐to‐treat lung carcinomas.
Exploring self‐disclosure between the survivor‐therapist and survivor‐clients: An autoethnography of the value of ‘sisterhood’ between female survivors of sexual violence
Authors: Bainbridge Amanda 
Published: August 2022

AbstractBackgroundThis autoethnographic study explores the interrelationships between self‐disclosure and working as a survivor‐therapist with clients who are also survivors of sexual violence. Themes explored include post‐traumatic growth of the author in relation to two occurrences of therapy and within the training experience, the concept of sisterhood between female survivors, and impact of self‐disclosure from the survivor‐therapist.AimThe aim was to explore how survivor‐therapist self‐disclosure might impact the therapeutic experience for clients identifying as survivors.MethodologyAn autoethnographic three‐phased approach was created to collate and analyse data from the author's personal and reflective journals, spanning the journey from client to qualified therapist. Themes analysed were as follows: “post‐traumatic growth,” “sisterhood” and “self‐disclosure.”FindingsThis research demonstrates the value of sisterhood between female identifying survivors of sexual violence and highlights the implicit “knowing” that may deepen the therapeutic relationship where therapist self‐disclosure is used judiciously in service of the client.ImplicationsThe research is situated in contribution to an existing dialogue, and recommendations are made for practice improvement and towards generation of ongoing research within a wider social narrative.
Self‐compassion, coping strategies and gender differences in psychology, counselling and psychotherapy practitioners during COVID‐19: Lessons learnt
Authors: Keyes Jessica , Yankouskaya Ala , Panourgia Constantina 
Published: August 2022

AbstractEffective coping strategies can protect against the adverse effects of stress. This study investigated self‐compassion's ability to predict approach and avoidance coping in psychology, counselling and psychotherapy practitioners (PCPPs) during COVID‐19, and whether this differed between genders. To date, no research has investigated this relationship, despite positive associations being drawn in other populations. Three hundred and nineteen PCPPs completed an online survey including the Brief COPE and Self‐Compassion Short Form. Self‐compassion significantly predicted greater use of approach coping and reduced use of avoidance coping. The predictive ability of self‐compassion was slightly better in female practitioners. Self‐judgement arose as a prominent subscale of self‐compassion across genders, increasing both approach and avoidance coping. Implications for future research and practice are discussed, concerning barriers to self‐compassion and the requirement of therapeutic programmes and psychoeducation as a prerequisite for effective coping strategies in the PCPP population.
An Overview on Synthetic and Medicinal Perspectives of [1,2,4]Triazolo[1,5‐a]pyrimidine Scaffold
Authors: Merugu Srinivas Reddy , Cherukupalli Srinivasulu , Karpoormath Rajshekhar 
Published: August 2022

Abstract[1,2,4]Triazolo[1,5‐a]pyrimidine is an important heterocyclic scaffold known to have a wide range of pharmacological activities such as anticancer, antimicrobial, anti‐tubercular, CB2 cannabinoid agonists, feticide, and adenosine antagonists. Several clinical trials and marketed drugs such as Trapidil, Essramycin, Pyroxsulam, DSM‐265, Flumetsulam, GNF‐6702, and Cevipabulin indicate the potential of [1,2,4]triazolo[1,5‐a]pyrimidine moiety with various functional groups in medicinal chemistry. Herein, we represent a concise report focusing on the synthetic strategies used for diversely substituted [1,2,4]triazolo[1,5‐a]pyrimidine analogs and their pharmacological applications. To the best of our knowledge, since 1980, we are the first to write a review on this emerging scaffold, which reveals the synthetic strategies, and pharmacological activities of differently substituted [1,2,4]triazolo[1,5‐a]pyrimidine with special emphasis on structure‐activity relationship studies.
AIEgens Based on Anion‐π+ Interactions: Design, Synthesis, Photophysical Properties, and Their Applications in Material Science and Biology
Authors: Lal Koner Apurba , Chopra Deepak , Patil Nitin T. 
Published: August 2022

AbstractThe design of novel aggregation‐induced emission luminogens (AIEgens), has generally been facilitated by disrupting the possibility of π‐π stacking. The recent literature describes a novel strategy to design AIEgens by introducing anion‐π+ interactions to prevent the detrimental π‐π stacking. This new strategy provides access to intrinsically charged AIEgens whose photophysical properties can be tuned either by incorporating different substituents on the π‐molecular scaffold to modulate the acidity for tuning the interaction energy between a π‐acceptor and counter‐anions. This concept article provides a brief overview of the field, focusing on the synthesis of AIEgens, their photophysical properties, crystallography studies and their applications in live cell fluorescence imaging.
Hypoxia‐induced miR‐182‐5p regulates vascular smooth muscle cell phenotypic switch by targeting RGS5
Authors: Wang Xiaozhou , Xu Xiaolong , Zhu Qinfang , Han Ying , Zhang Wei 
Published: August 2022

AbstractIn response to vascular injury or alterations in the local environment, such as hypoxia and hypertension, contractile vascular smooth muscle cells (VSMCs) are able to switch to a synthetic phenotype characterized by increased extracellular matrix synthesis with decreased expression of contractile markers. miR‐182‐5p has recently been reported to play a regulatory role in VSMCs proliferation. However, little is known about its target genes and related pathways in VSMCs phenotypic switch. Here, we investigated the function of miR‐182‐5p in VSMCs phenotypic switch. The results showed that upregulation of miR‐182‐5p promoted the switching of VSMCs from a contractile to a synthetic phenotype under hypoxic conditions. Mechanistically, hypoxia elevated miR‐182‐5p, leading to a reduction in expression of contractile markers and weakened RhoA signaling. Using bioinformatics analysis, dual‐luciferase reporter assays and rescue assays, we demonstrated that miR‐182‐5p suppressed RhoA signaling by targeting RGS5. Collectively, the results from the present study indicated that miR‐182‐5p/RGS5/RhoA axis regulated hypoxia‐induced VSMCs phenotypic switch.