bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness of internet-supported cognitive behavioral therapy for university students with anxiety symptoms: A Markov-model analysis
Authors: You Joyce H. S. , Luk Scotty W. C. , Chow Dilys Y. W. , Jiang Xinchan , Mak Arthur D. P. , Mak Winnie W. S. 
Published: May 2022

Background and aim
High prevalence of anxiety symptoms has been reported globally in the university students. Cognitive behavioral therapy (CBT) is the recognized treatment for anxiety and is traditionally conducted face-to-face (f-CBT). The efficacy of internet-based CBT (i-CBT) for anxiety has been extensively studied, yet evidence on its cost-effectiveness is scarce. We aimed to evaluate the cost-effectiveness of guided low-intensity i-CBT for university students with mild anxiety symptoms from the societal perspective of Hong Kong.

Methods
A 5-year Markov model was designed to compare outcomes of guided i-CBT and f-CBT in a hypothetical cohort of university students with mild anxiety symptoms. Model inputs of cost and healthcare resources associated with anxiety were retrospectively collected from a cohort of university students with anxiety symptoms. Clinical and utility model inputs were retrieved from published literature. Model outcome measures were anxiety-related total cost (including direct medical and indirect costs) and quality-adjusted life-year (QALY). Sensitivity analyses were performed to examine the robustness of base-case results.

Results
In base-case analysis, i-CBT gained higher QALYs (2.9956 versus 2.9917) at lower total cost (US$6,101 versus US$6,246) than f-CBT. In one-way sensitivity analysis, the QALY gained by i-CBT was sensitive to the relative patient acceptance and adherence to CBT. In probabilistic sensitivity analysis, i-CBT was cost-effective in 90.9% of the time at the willingness-to-pay threshold of 138,210 per QALY (3× GDP per capita in Hong Kong). The probability of i-CBT to be cost-effective was 99.9% at a willingness-to-pay threshold of zero.

Conclusions
Guided i-CBT appears to be cost-saving and effective for management of university students with mild symptoms of anxiety from the societal perspective of Hong Kong. The cost-effectiveness of i-CBT is highly subject to the individual acceptance and adherence of CBT delivered by the internet platform.
Using standard-length compactors to implant short humeral stems in total shoulder arthroplasty: A cadaver study of humeral stem alignment
Authors: Gunst Stanislas , Nigues Ana , Vogels Jérôme , Servien Elvire , Lustig Sébastien , Nove-Josserand Laurent , Collotte Philippe 
Published: May 2022

Background
Short-stem implants in shoulder arthroplasty were recently developed and reported clinical outcomes are good. However, radiological analysis often reveals humeral stem misalignment in the frontal plane, along with high filling ratios that can lead to proximal bone remodeling under stress shielding. The aim of this cadaveric study was to test whether using compactors for standard-length (> 100 mm) stems to implant short (< 100 mm) stems reduces the risk of stem misalignment without compromising in terms of a higher filling ratio.

Methods
In a cadaveric study, twenty short stems were implanted using instrumentation for standard-length stems. Alignment and filling ratios were evaluated on anteroposterior radiographs for both the compactors and the stems. The angular deviations (α) from the humeral axis of the compactors and the short stems were measured. Misalignment was defined as |α| > 5°. Metaphyseal and diaphyseal filling ratios were calculated and defined as either high (≥ 0.7) or low (< 0.7).

Results
The median angular deviations of the compactors and the short stems were respectively 1.6° (range, 0.03 to 5.9°) and 1.3° (range, 0.3 to 9.6°). Nineteen of the 20 compactors (95%) and 17/20 short stems (85%) were correctly aligned. The proportions of correctly aligned compactors and stems were not significantly different (95% CI, −0.33 to 0.11; Z-test of proportions p = .60), and the respective angular deviations were significantly correlated (Spearman ρ = .60, p = 0.006). The diaphyseal and metaphyseal filling ratios of the compactors and the stems were all low.

Conclusions
In this series of 20 implants in cadavers, the narrow short humeral stems implanted with compactors for standard-length stems were correctly aligned with the humeral axis. This approach may be a way to achieve both correct frontal alignment and low filling ratios.
Thapsigargin blocks electromagnetic field‐elicited intracellular Ca2+ increase in HEK 293 cells
Authors: Bertagna Federico , Lewis Rebecca , Silva S. Ravi P. , McFadden Johnjoe , Jeevaratnam Kamalan 
Published: May 2022

AbstractBiological effects of electromagnetic fields (EMFs) have previously been identified for cellular proliferation and changes in expression and conduction of diverse types of ion channels. The major effect elicited by EMFs seems to be directed toward Ca2+ homeostasis. This is particularly remarkable since Ca2+ acts as a central modulator in various signaling pathways, including, but not limited to, cell differentiation and survival. Despite this, the mechanisms underlying this modulation have yet to be unraveled. Here, we assessed the effect of EMFs on intracellular [Ca2+], by exposing HEK 293 cells to both radio‐frequency electromagnetic fields (RF‐EMFs) and static magnetic fields (SMFs). We detected a constant and significant increase in [Ca2+] subsequent to exposure to both types of fields. Strikingly, the increase was nulled by administration of 10 μM Thapsigargin, a blocker of sarco/endoplasmic reticulum Ca2+‐ATPases (SERCAs), indicating the involvement of the endoplasmic reticulum (ER) in EMF‐related modulation of Ca2+ homeostasis.
The effect of non‐oral hormonal contraceptives on hypertension and blood pressure: A systematic review and meta‐analysis
Authors: Kalenga Cindy Z. , Dumanski Sandra M. , Metcalfe Amy , Robert Magali , Nerenberg Kara A. , MacRae Jennifer M. , Premji Zahra , Ahmed Sofia B. 
Published: May 2022

AbstractOral contraceptives (OC) are associated with increased risk of hypertension and elevated blood pressure (BP). Whether non‐oral hormonal contraceptives have similar associations is unknown. We sought to investigate the effect of non‐oral hormonal contraceptive (NOHC) use on the risk of hypertension and changes in BP, compared to non‐hormonal contraceptive and OC use. We searched bibliographic databases (MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials) until August 2020. Studies reporting risk of hypertension or changes in systolic and diastolic BP with NOHC use compared with either non‐hormonal contraceptive or OC use. Abstract screening, full‐text review, data extraction, and quality assessment were completed in duplicate. For studies reporting dichotomous outcomes, we reported results as relative risk with 95% confidence intervals (CI). A random‐effects model was used to estimate pooled weighted mean difference and 95% CI of change in BP. Twenty‐five studies were included. A lower incidence of hypertension was observed with injectable contraceptive use compared to non‐hormonal contraceptive and OC use, although it was unclear if this was statistically significant. Compared to non‐hormonal contraceptive use, injectable contraceptive use was associated with increased BP (SBP: 3.24 mmHg, 95%CI 2.49 to 3.98 mmHg; DBP: 3.15 mmHg, 95%CI 0.09 to 6.20 mmHg), the hormonal intra‐uterine device use was associated with reduced BP (SBP: −4.50 mmHg, 95%CI −8.44 to −0.57 mmHg; DBP: −7.48 mmHg, 95% −14.90 to −0.05 mmHg), and the vaginal ring was associated with reduced diastolic BP (−3.90 mmHg, 95%CI −6.67 to −1.13 mmHg). Compared to OC use, the injectable contraceptive use was associated with increased diastolic BP (2.38 mmHg, 95%CI 0.39 to 4.38 mmHg). NOHC use is associated with changes in BP which differ by type and route of administration. Given the strong association between incremental increases in BP and cardiovascular risk, prospective studies are required.
Heightened levels of plasma growth differentiation factor 15 in men living with HIV
Authors: Agarwal Neeti , Ramirez Bustamante Claudia E. , Wu Huaizhu , Armamento‐Villareal Reina , Lake Jordan E. , Balasubramanyam Ashok , Hartig Sean M. 
Published: May 2022

AbstractPlasma biomarkers that reflect energy balance disorders in people living with HIV (PLWH) remain limited. Growth differentiation factor 15 (GDF15) abundance in plasma of mice and humans induces negative energy balance but also becomes highly elevated in obesity and other metabolic diseases. We sought to compare plasma GDF15 levels in PLWH and HIV‐negative persons and mouse models expressing the HIV accessory protein Vpr (that recapitulate HIV‐associated metabolic disorders) and determine their relationship to metabolic parameters. We measured liver Gdf15 mRNA levels and plasma GDF15 levels in male Vpr mice and littermate controls. In parallel, we analyzed plasma GDF15 levels in 18 male PLWH on stable, long‐term antiretroviral therapy and 13 HIV‐negative men (6 healthy controls and 7 with metabolic syndrome). Plasma GDF15 levels were correlated with anthropometric and immune cell parameters in humans. Gene expression analysis of Vpr mouse liver demonstrated elevated Gdf15 mRNA. Plasma GDF15 levels were also higher in Vpr mouse models. Levels of plasma GDF15 in PLWH were greater than in both HIV‐negative groups and correlated positively with the CD4/CD8 T cell ratio in PLWH. Plasma GDF15 levels correlated positively with age in the HIV‐negative subjects but not in PLWH. Since GDF15 levels predict fatty liver disease and energy balance disorders, further studies are warranted to determine the effect of GDF15 in mediating the metabolic disturbances that occur in Vpr mice and PLWH.
Adolescent Korean returnees’ perceptions of the change of language learning contexts as bilingual learners
Authors: Shin Ji Hye 
Published: May 2022

Abstract
There are growing populations of Korean children who studied abroad in the English as a second language (ESL) context and had to return to Korea for various reasons before reaching college age. These returnees are concerned about how to maintain (or improve) their English proficiency in the EFL (English as a foreign language) context. The purpose of this qualitative case study was to investigate two Korean-English bilinguals who recently returned to Korea after learning English in the US for more than four years. The research questions were as follows: 1) How do Korean returnees perceive the change of learning status as Korean-English bilinguals in the US and Korea, and 2) What motivated Korean returnees to sustain their English proficiency while acquiring academic literacy in Korean? By using the case study method, an extensive and in-depth description of two Korean returnees’ English language learning experiences was provided. Data were collected through semi-structured interviews and observation. The analysis showed that the switch from ESL to EFL learning environments, which includes the change of language, culture, and social contexts, influenced how Korean returnees maintain/improve their English proficiency, specifically with their language learning strategies (LLS).
Estimating urine albumin to creatinine ratio from protein to creatinine ratio using same day measurement: validation of equations
Authors: Résimont Guillaume , Vranken Laura , Pottel Hans , Jouret François , Krzesinski Jean-Marie , Cavalier Etienne , Delanaye Pierre 
Published: May 2022

Abstract

Objectives
Severity of chronic kidney disease is defined by glomerular filtration rate (GFR) and albuminuria (ACR) by the KDIGO and are related to cardiovascular outcomes and end-stage-kidney-failure. However, proteinuria (PCR) is more often available than ACR in records. Recently, equations were developed to estimate ACR from PCR. We investigated their performances in our population.

Methods
In the academic medical hospital of Liège, we retrospectively analysed same day measurement of ACR and PCR and staged them according to the KDIGO A1-A2-A3 categories. Analyser Roche Cobas (R) gathered 2,633 urinalysis (May 2018-May 2019) and analyser Abbott Alinity (A) 2,386 urinalysis (May 2019-March 2020). We compared the KDIGO staging of mACR and eACR obtained from Weaver’s and Sumida’s equations.

Results
Median age was 63 [52;71]/64 [53;72] years old, 43/42% were female; 78/74% had diabetes; proportion of mACR-A1 was 65.6%/64.2%, A2 was 25.5%/25.5% and A3 was 8.8%/10.3% (Method R/A, respectively). Both equations gave similar distribution of KDIGO staging of eACR. Overall agreements were higher than 88% regardless of the analyser or of the equation. Performances in between equations were equivalent according to the multi-level AUC (multinomial logistic regression model).

Conclusions
Good concordance was observed between mACR and eACR regardless of the equation or of the analyser. No patient with an A3-measured ACR was estimated within the KDIGO A1 category. Though ACR should be measured when clinically needed, it may be reasonably estimated from the PCR through these equations, for epidemiologic retrospective studies or research purposes.
How is test laboratory data used and characterised by machine learning models? A systematic review of diagnostic and prognostic models developed for COVID-19 patients using only laboratory data
Authors: Carobene Anna , Milella Frida , Famiglini Lorenzo , Cabitza Federico 
Published: May 2022

Abstract
The current gold standard for COVID-19 diagnosis, the rRT-PCR test, is hampered by long turnaround times, probable reagent shortages, high false-negative rates and high prices. As a result, machine learning (ML) methods have recently piqued interest, particularly when applied to digital imagery (X-rays and CT scans). In this review, the literature on ML-based diagnostic and prognostic studies grounded on hematochemical parameters has been considered. By doing so, a gap in the current literature was addressed concerning the application of machine learning to laboratory medicine. Sixty-eight articles have been included that were extracted from the Scopus and PubMed indexes. These studies were marked by a great deal of heterogeneity in terms of the examined laboratory test and clinical parameters, sample size, reference populations, ML algorithms, and validation approaches. The majority of research was found to be hampered by reporting and replicability issues: only four of the surveyed studies provided complete information on analytic procedures (units of measure, analyzing equipment), while 29 provided no information at all. Only 16 studies included independent external validation. In light of these findings, we discuss the importance of closer collaboration between data scientists and medical laboratory professionals in order to correctly characterise the relevant population, select the most appropriate statistical and analytical methods, ensure reproducibility, enable the proper interpretation of the results, and gain actual utility by using machine learning methods in clinical practice.
On linear chaos in function spaces
Authors: Jimenez John M. , Markin Marat V. 
Published: May 2022

Abstract
We show that, in

L

p

(

0
,
∞

)

{L}_{p}\left(0,\infty )

(

1
≤
p
<
∞

1\le p\lt \infty

), bounded weighted translations as well as their unbounded counterparts are chaotic linear operators. We also extend the unbounded case to

C

0

[

0
,
∞

)

{C}_{0}{[}0,\infty )

and describe the spectra of the weighted translations provided the underlying spaces are complex.
Application on oxidation behavior of metallic copper in fire investigation
Authors: Dongbai Xie , Hao Hong , Shuwang Duo , Qiang Li 
Published: May 2022

Abstract
In fire investigations, the most important aspect is determining the presence of a liquid accelerant at the fire scene. The presence or absence of accelerants is critical evidence during trials for fire cases. Upon exposure to high temperatures, metallic substances undergo oxidation, which can be imparted by accelerants in the fire. Oxides and substrates found on metal surfaces offer valuable information on the characteristics of fire, including exposure temperature, duration, and involvement of a liquid accelerant. In this study, we investigated the oxidation behavior of copper at high temperatures in a simulated flame environment using ethanol combustion. After oxidation, the morphological, oxide phase composition, and microstructural features of specimens were characterized by observation, X-ray diffraction, X-ray photoelectron energy spectroscopy, transmission electron microscopy, and scanning electron microscopy with energy-dispersive spectroscopic analysis. The elemental carbon with a hexagonal structure deposited on the sample’s surface was found, which may be incomplete combustion and the chemical composition of ethanol. Copper has a preferred orientation of oxide on the (111) crystal plane, which differs from oxidation in ordinary hot air that is related to the large Coulomb force of the (111) crystal plane. Hot air convection due to combustion may cause large areas of oxide layer on the copper surface to crack and peel. Oxide properties and surface state of metals strongly depended on oxidation duration, temperature, and atmosphere. These data shall offer reference information for determining the presence of combustion accelerants at fire scenes.
Description and determination in Tanti Dargwa NPs
Authors: Lander Yury 
Published: May 2022

AbstractThis paper focuses on the noun phrase in Tanti Dargwa (East Caucasian) and presents evidence for the distinction between modifiers proper (adjectival phrases, participial relative clauses and non-genitive adnominal NPs) and determiner-like elements (demonstratives, indefinite pronouns, numerals and most quantity expressions) in this language. Crucially, this dichotomy, which presumably reflects the distinction between the determinative and descriptive components in the NP, is realized in Tanti Dargwa mostly morphologically – in the distribution of “attributive markers” and in the expression of number. Syntactically, in the most neutral constructions the order of elements other than the head is virtually free and does not display any scope-related effects, while the head occupies the final position. In addition, Tanti Dargwa shows marginal constructions (a right-periphery construction locating a modifier after the head and a construction showing quasi-incorporation of a modifier into the noun) which are restricted to modifiers. Tanti Dargwa data support the idea that the description/determination distinction is gradual rather than discrete, as there are elements that show behavior intermediate between modifiers proper and determiner-like elements: possessor NPs, contrastive modifiers and the expressions like ‘other’.
Effect of tool rotational speed and position on mechanical and microstructural properties of friction stir welded dissimilar alloys AZ31B Mg and Al6061
Authors: Tolun Fatmagül 
Published: May 2022

Abstract
The existence of some problems in joining Al and Mg alloys using classical fusion welding methods causes limitations in the use of Mg and Al alloys in common structures. Friction stir welding (FSW) is a solid-state welding method for joining materials having same or different properties at temperatures below their melting points. In this study, dissimilar alloys AZ31B Mg and Al6061 were joined by FSW at a feed rate of 34 mm·min−1 and at different tool rotational speeds (600 and 700 rpm) and material positions. During the welding process, AZ31B Mg plate was positioned at the advancing side and Al6061 was located at the retreating side, and moreover, the two alloys were also positioned vice versa. Tensile strength and microhardness tests were performed to examine the mechanical properties of the welded specimens. The microstructures of the welded zones were examined by obtaining the optical microscopic (OM) and scanning electron microscopic (SEM) images. The highest welding strength was obtained from the specimen welded at a tool rotational speed of 600 rpm, at a feed rate of 34 mm·min−1 and by locating AZ31B Mg on the advancing side.
My journey in chemistry education
Authors: Chiu Mei-Hung 
Published: May 2022

Abstract
Chemistry is filled with complex and abstract concepts in interconnected systems. It is considered as the central science for linking with other scientific disciplines. Chemistry cannot be separated from our daily life. But it has been a challenge for school students to learn its concepts at various levels of educational systems. In this article, I will start with an introduction on investigations of students’ conceptions of chemical concepts, teachers’ understanding of students’ knowledge of scientific phenomena, and strategies for promoting students’ conceptual change in learning science, including model-based and modeling-based instruction as well as adoption of innovative technology in learning sciences (such as, the use of facial expressions system augmented reality and virtual reality in learning chemistry). And then, I will describe a few outreach activities on promoting public understanding of chemistry, developing educators’ competence in teaching chemistry, as well as investigation on gender gap in STEM sponsored by ISC, IUPAC and other unions and partners.
Tibiotalocalcaneal nailing for osteoporotic ankle fractures in the frail patient: a narrative review with a clinical score proposal for the decision-making process
Authors: Herrera-Pérez Mario , Martín-Vélez Pablo , González-Martín David , Domínguez-Meléndez Miguel , Galhoum Ahmed E , Valderrabano Victor , Tejero Sergio 
Published: May 2022

Osteoporotic ankle fractures result from mechanical forces that would not ordinarily result in fracture, known as ‘low-energy’ trauma, such as those equivalent to a fall from a standing height or less.
Osteoporotic ankle fractures in frail patients are becoming more and more frequent in daily practice and represent a therapeutic challenge for orthopaedic surgeons.
The main problems with frail patients are the poor condition of the soft tissues around the ankle, dependence for activities of daily living and high comorbidity.
The decision to operate on these patients is complex because conservative treatment is poorly tolerated in unstable fractures and conventional open reduction and internal fixation is associated with a high rate of complications.
The authors conducted a narrative review of the literature on primary tibiotalocalcaneal nailing of ankle fractures in frail patients and categorized the different factors to consider when treatment is indicated for this conditon. Difficulty of ambulation, age over 65 years old, deteriorated baseline state and instability of the fracture were the most frequently considered factors.
Finally, the authors propose an easy and quick clinical scoring system to help in the decision-making process, although further comparative studies are required to explore its validity.