bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hippocampal glutathione depletion with enhanced iron level in patients with mild cognitive impairment and Alzheimer’s disease compared with healthy elderly participants
Authors: Mandal Pravat K , Goel Anshika , Bush Ashley I , Punjabi Khushboo , Joon Shallu , Mishra Ritwick , Tripathi Manjari , Garg Arun , Kumar Natasha K , Sharma Pooja , Shukla Deepika , Ayton Scott Jonathan , Fazlollahi Amir , Maroon Joseph C , Dwivedi Divya , Samkaria Avantika , Sandal Kanika , Megha Kanu , Shandilya Sandhya 
Published: August 2022

Abstract
Oxidative stress has been implicated in Alzheimer’s disease, and it is potentially driven by the depletion of primary antioxidant, glutathione, as well as elevation of the pro-oxidant, iron. Present study evaluates glutathione level by magnetic resonance spectroscopy, iron deposition by quantitative susceptibility mapping in left hippocampus, as well as the neuropsychological scores of healthy old participants (N = 25), mild cognitive impairment (N = 16) and Alzheimer’s disease patients (N = 31). Glutathione was found to be significantly depleted in mild cognitive impaired (P &lt; 0.05) and Alzheimer’s disease patients (P &lt; 0.001) as compared with healthy old participants. A significant higher level of iron was observed in left hippocampus region for Alzheimer’s disease patients as compared with healthy old (P &lt; 0.05) and mild cognitive impairment (P &lt; 0.05). Multivariate receiver-operating curve analysis for combined glutathione and iron in left hippocampus region provided diagnostic accuracy of 82.1%, with 81.8% sensitivity and 82.4% specificity for diagnosing Alzheimer’s disease patients from healthy old participants. We conclude that tandem glutathione and iron provides novel avenue to investigate further research in Alzheimer’s disease.
Unified fuzzy logic controller and power management for an isolated residential hybrid PV/diesel/battery energy system
Authors: Atoui Adil , Seghir Boucherit Mohamed , Benmansour Khelifa , Barkat Said , Djerioui Ali , Houari Azeddine 
Published: August 2022

Abstract
Hybrid systems based on renewable energies for the electrification of remote sites controlled by power management systems (PMSs) aim to reduce fossil fuels and increase the efficiency of renewable energy sources to minimize greenhouse gas emissions. The influential role of the PMS contributes to improving the efficiency and effectiveness of these systems by ensuring a balance between the different sources and loads in all operating modes. However, the abrupt transitions between the various operational modes selected by the PMS generate power loss and imbalance. To handle this issue, a fuzzy logic controller (FLC)-based PMS controlling a photovoltaic (PV) and diesel hybrid system with a battery storage element connected to a DC bus is proposed in this paper. The proposed PMS is wholly based on FLC to ensure a smooth transition between the different modes of the system. The success of using the suggested PMS lies in how well the FLC parameters are chosen before the system is processed. For this purpose, the particle swarm optimization algorithm is adapted to tune the FLC parameters. The resulting optimal intelligent PMS is tested and compared with a classical one using comprehensive simulations performed in a Simscape ElectricalTM MATLAB® environment. The obtained results show an overshoot attenuation at the DC-bus voltage of 2% when changing the mode and an improvement in the PV generator efficiency by 99.5%.
Oral Nirmatrelvir and Ritonavir in Nonhospitalized Vaccinated Patients With Coronavirus Disease 2019
Authors: Ganatra Sarju , Dani Sourbha S , Ahmad Javaria , Kumar Ashish , Shah Jui , Abraham George M , McQuillen Daniel P , Wachter Robert M , Sax Paul E 
Published: August 2022

AbstractBackgroundTreatment of coronavirus disease 2019 (COVID-19) with nirmatrelvir plus ritonavir (NMV-r) in high-risk nonhospitalized unvaccinated patients reduced the risk of progression to severe disease. However, the potential benefits of NMV-r among vaccinated patients are unclear.MethodsWe conducted a comparative retrospective cohort study using the TriNetX research network. Patients ≥18 years of age who were vaccinated and subsequently developed COVID-19 between 1 December 2021 and 18 April 2022 were included. Cohorts were developed based on the use of NMV-r within 5 days of diagnosis. The primary composite outcome was all-cause emergency room (ER) visit, hospitalization, or death at a 30-day follow-up. Secondary outcomes included individual components of primary outcomes, multisystem symptoms, COVID-19–associated complications, and diagnostic test utilization.ResultsAfter propensity score matching, 1130 patients remained in each cohort. A primary composite outcome of all-cause ER visits, hospitalization, or death in 30 days occurred in 89 (7.87%) patients in the NMV-r cohort compared with 163 (14.4%) patients in the non–NMV-r cohort (odds ratio: .5; 95% confidence interval: .39–.67; P &lt; .005) consistent with 45% relative risk reduction. A significant reduction in multisystem symptom burden and subsequent complications, such as lower respiratory tract infection, cardiac arrhythmia, and diagnostic radiology testing, were noted in NMV-r–treated patients. There was no apparent increase in serious complications between days 10 and 30.ConclusionsTreatment with NMV-r in nonhospitalized vaccinated patients with COVID-19 was associated with a reduced likelihood of ER visits, hospitalization, or death. Complications and overall resource utilization were also decreased.
Cryptococcal Antigenemia in Advanced Human Immunodeficiency Virus Disease: Pathophysiology, Epidemiology, and Clinical Implications
Authors: Wake Rachel M , Molloy Síle F , Jarvis Joseph N , Harrison Thomas S , Govender Nelesh P 
Published: August 2022

AbstractCryptococcal antigen (CrAg) is detectable in blood prior to the onset of symptomatic cryptococcal meningitis (CM), a leading cause of death among people with advanced human immunodeficiency virus (HIV) disease globally. Highly sensitive assays can detect CrAg in blood, and screening people with HIV with low CD4 counts, followed by preemptive antifungal treatment, is recommended and widely implemented as part of a global strategy to prevent CM and end cryptococcal-related deaths. Cryptococcal antigenemia encompasses a spectrum of conditions from preclinical asymptomatic infection (cerebrospinal fluid [CSF] CrAg-negative) through subclinical (CSF CrAg-positive without overt meningism) to clinical symptomatic cryptococcal disease, usually manifesting as CM. In this review, we summarize current understanding of the pathophysiology, risk factors for, and clinical implications of cryptococcal antigenemia within this spectrum. We also provide an update on global prevalence, recommended screening and treatment strategies, and future considerations for improving outcomes among patients with cryptococcal antigenemia.
Human Immunodeficiency Virus Type 1 RNA Levels in Rectal and Seminal Compartments After Switching to Long-Acting Cabotegravir Plus Rilpivirine: A Longitudinal Study
Authors: Masiá Mar , Fernández-González Marta , Agulló Vanesa , Mascarell Paula , Padilla Sergio , García-Abellán Javier , Gutiérrez Félix 
Published: August 2022

Abstract

Human immunodeficiency virus type 1 RNA levels were longitudinally evaluated in 211 rectal and 152 seminal samples from 12 virologically suppressed participants switching to monthly long-acting cabotegravir plus rilpivirine or continuing with daily dolutegravir-abacavir-lamivudine. Maintenance of viral suppression in rectal and seminal compartments was comparable, and blips occurred with similar frequency with both treatment regimens.

Clinical Trials Registration
NCT02938520.
The microsomal prostaglandin E synthase-1/prostaglandin E2 axis induces recovery from ischaemia via recruitment of regulatory T cells
Authors: Amano Hideki , Eshima Koji , Ito Yoshiya , Nakamura Masaki , Kitasato Hidero , Ogawa Fumihiro , Hosono Kanako , Iwabuchi Kazuya , Uematsu Satoshi , Akira Shizuo , Narumiya Shuh , Majima Masataka 
Published: August 2022

Abstract

Aims
Microsomal prostaglandin E synthase-1 (mPGES-1)/prostaglandin E2 (PGE2) induces angiogenesis through the prostaglandin E2 receptor (EP1–4). Among immune cells, regulatory T cells (Tregs), which inhibit immune responses, have been implicated in angiogenesis, and PGE2 is known to modulate the function and differentiation of Tregs. We hypothesized that mPGES-1/PGE2-EP signalling could contribute to recovery from ischaemic conditions by promoting the accumulation of Tregs.

Methods and results
Wild-type (WT), mPGES-1-deficient (mPges-1−/−), and EP4 receptor-deficient (Ep4−/−) male mice, 6–8 weeks old, were used. Hindlimb ischaemia was induced by femoral artery ligation. Recovery from ischaemia was suppressed in mPges-1−/− mice and compared with WT mice. The number of accumulated forkhead box protein P3 (FoxP3)+ cells in ischaemic muscle tissue was decreased in mPges-1−/− mice compared with that in WT mice. Expression levels of transforming growth factor-β (TGF-β) and stromal cell derived factor-1 (SDF-1) in ischaemic tissue were also suppressed in mPges-1−/− mice. The number of accumulated FoxP3+ cells and blood flow recovery were suppressed when Tregs were depleted by injecting antibody against folate receptor 4 in WT mice but not in mPges-1−/− mice. Recovery from ischaemia was significantly suppressed in Ep4−/− mice compared with that in WT mice. Furthermore, mRNA levels of Foxp3 and Tgf-β were suppressed in Ep4−/− mice. Moreover, the number of accumulated FoxP3+ cells in ischaemic tissue was diminished in Ep4−/− mice compared with that in Ep4+/+ mice.

Conclusion
These findings suggested that mPGES-1/PGE2 induced neovascularization from ischaemia via EP4 by promoting the accumulation of Tregs. Highly selective EP4 agonists could be useful for the treatment of peripheral artery disease.
Chromosome-Level Genome Assembly of Callitettix versicolor (Rice Spittlebug)
Authors: Chen Hong , Qiao Gexia , Liang Aiping 
Published: August 2022

Abstract
The spittlebug family Cercopidae (Hemiptera: Auchenorrhyncha: Cicadomorpha: Cercopoidea) is distributed worldwide. Some Cercopidae species are agricultural pests that are responsible for substantial economic damage. However, the genomics of spittlebugs has rarely been studied and their complete genome assembly is yet to be reported. Here, we present the draft reference genome of Callitettix versicolor Fabricius (Hemiptera: Cercopidae) at the chromosome level. The assembled draft genome was 974.99 Mb with a contig N50 of 5.63 Mb, and the longest contig being 24.54 Mb. Hi-C technology was used to obtain an approximately 958.71 Mb chromosome-level genome on 10 pseudochromosomes, which covered 98.33% of the assembly. Repeat sequences accounted for 38.88% of the genomic sequences. A total of 21,937 protein-coding genes were detected in the reference genome, 89.97% of which were annotated in public databases. The high-quality reference genome of C. versicolor reported in this study will provide a valuable genomic resource for future ecological and evolutionary studies of spittlebugs.
Protection of Reputation, Good Name and Personality Rights in Cross-Border Digital Media
Authors: De Miguel Asensio Pedro 
Published: August 2022

Abstract
Following the recent judgments of the Court of Justice in Mittelbayerischer Verlag and Gtflix tv, this paper analyses the European Union framework in relation to the enforcement of rights relating to personality, including those of legal persons, against harmful content posted online. As regards jurisdiction, special attention is given to the scope of the centre of interest of the victim as ground for jurisdiction. Furthermore, the fragmentation that results from attributing jurisdiction to the courts of the place(s) where the damage occurs under the so-called mosaic approach is discussed. Particular attention is devoted to the difficulties that arise in relation to the broad understanding by the Court of Justice of the place where the damage occurs as the connecting factor and its position regarding the mere accessibility of online content as the decisive element for determining jurisdiction. Additionally, the interplay between jurisdiction and choice of law and its implications on the territorial scope of orders and the cross-border recognition of judgments are considered.
Diagnosing Alzheimer’s Disease Specifically and Sensitively With pLG72 and Cystine/Glutamate Antiporter SLC7A11 AS Blood Biomarkers
Authors: Lane Hsien-Yuan , Lin Chieh-Hsin 
Published: August 2022

Abstract

Background
Reliable blood biomarkers for Alzheimer’s disease (AD) have been lacking. The D-amino acids oxidase modulator (named pLG72) modulates glutamate N-methyl-D-aspartate receptor activity. The cystine/glutamate antiporter contains a SLC7A11 subunit, which mediates glutamate release. This study aimed to determine the accuracy of pLG72 protein and SLC7A11 mRNA in diagnosing AD.

Methods
This study enrolled 130 healthy controls and 109 unmatched AD patients; among them, 40 controls and 70 patients were selected to match by age. We measured their pLG72 protein in plasma and SLC7A11 mRNA in white blood cells.

Results
AD patients had markedly higher pLG72 levels and SLC7A11 mRNA ΔCT values than healthy controls (in both unmatched and matched cohorts; all 4 P values &lt;.001). The receiver operating characteristics analysis in the unmatched cohorts demonstrated that the pLG72 level had a high specificity (0.900) at the optimal cutoff value of 2.3285, the ΔCT of SLC7A11 mRNA displayed an excellent sensitivity (0.954) at the cutoff of 12.185, and the combined value of pLG72 and SLC7A11 ΔCT determined a favorable area under the curve (AUC) (0.882) at the cutoff of 21.721. The AUC of the combined value surpassed that of either biomarker. The specificity, sensitivity, and AUC of the matched cohort were like those of the unmatched cohort.

Conclusions
The findings suggest that pLG72 protein and SLC7A11 mRNA can distinguish AD patients from healthy controls with excellent specificity and sensitivity, respectively. The combination of pLG72 and SLC7A11 yields better AUC than either, suggesting the superiority of simultaneously measuring both biomarkers in identifying AD patients.
An asymptotic-preserving discretization scheme for gas transport in pipe networks
Authors: Egger H , Giesselmann J , Kunkel T , Philippi N 
Published: August 2022

Abstract
We consider the simulation of barotropic flow of gas in long pipes and pipe networks. Based on a Hamiltonian reformulation of the governing system, a fully discrete approximation scheme is proposed using mixed finite elements in space and an implicit Euler method in time. Assuming the existence of a smooth subsonic solution bounded away from vacuum, a full convergence analysis is presented based on relative energy estimates. Particular attention is paid to establishing error bounds that are uniform in the friction parameter. As a consequence, the method and results also cover the parabolic problem arising in the asymptotic large friction limit. The error estimates are derived in detail for a single pipe, but using appropriate coupling conditions and the particular structure of the problem and its discretization, the main results directly generalize to pipe networks. Numerical tests are presented for illustration.
Multilevel representations of isotropic Gaussian random fields on the sphere
Authors: Bachmayr Markus , Djurdjevac Ana 
Published: August 2022

Abstract
Series expansions of isotropic Gaussian random fields on $\mathbb {S}^2$ with independent Gaussian coefficients and localized basis functions are constructed. Such representations with multilevel localized structure provide an alternative to the standard Karhunen–Loève expansions of isotropic random fields in terms of spherical harmonics. The basis functions are obtained by applying the square root of the covariance operator to spherical needlets. Localization of the resulting covariance-dependent multilevel basis is shown under decay conditions on the angular power spectrum of the random field. In addition, numerical illustrations are given and an application to random elliptic PDEs on the sphere is analysed.
DDX58 Is Associated With Susceptibility to Severe Influenza Virus Infection in Children and Adolescents
Authors: Lee Sanghun , Zhang Yu , Newhams Margaret , Novak Tanya , Thomas Paul G , Mourani Peter M , Hall Mark W , Loftis Laura L , Cvijanovich Natalie Z , Tarquinio Keiko M , Schwarz Adam J , Weiss Scott L , Thomas Neal J , Markovitz Barry , Cullimore Melissa L , Sanders Ronald C , Zinter Matt S , Sullivan Janice E , Halasa Natasha B , Bembea Melania M , Giuliano John S , Typpo Katri V , Nofziger Ryan A , Shein Steven L , Kong Michele , Coates Bria M , Weiss Scott T , Lange Christoph , Su Helen C , Randolph Adrienne G ,   for the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Pediatric Intensive Care Influenza (PICFlu) Investigators and the Trans-Omics for Precision Medicine (TOPMed) Investigators
Published: August 2022

Abstract

Background
Seasonal influenza virus infection causes a range of disease severity, including lower respiratory tract infection with respiratory failure. We evaluated the association of common variants in interferon (IFN) regulatory genes with susceptibility to critical influenza infection in children.

Methods
We performed targeted sequencing of 69 influenza-associated candidate genes in 348 children from 24 US centers admitted to the intensive care unit with influenza infection and lacking risk factors for severe influenza infection (PICFlu cohort, 59.4% male). As controls, whole genome sequencing from 675 children with asthma (CAMP cohort, 62.5% male) was compared. We assessed functional relevance using PICFlu whole blood gene expression levels for the gene and calculated IFN gene signature score.

Results
Common variants in DDX58, encoding the retinoic acid–inducible gene I (RIG-I) receptor, demonstrated association above or around the Bonferroni-corrected threshold (synonymous variant rs3205166; intronic variant rs4487862). The intronic single-nucleotide polymorphism rs4487862 minor allele was associated with decreased DDX58 expression and IFN signature (P &lt; .05 and P = .0009, respectively) which provided evidence supporting the genetic variants’ impact on RIG-I and IFN immunity.

Conclusions
We provide evidence associating common gene variants in DDX58 with susceptibility to severe influenza infection in children. RIG-I may be essential for preventing life-threatening influenza-associated disease.
Calf rumen microbiome from birth to weaning and shared microbial properties to the maternal rumen microbiome
Authors: Woodruff Kelly L , Hummel Gwendolynn L , Austin Kathleen J , Lake Scott L , Cunningham-Hollinger Hannah C 
Published: August 2022

AbstractOptimization of host performance in cattle may be achieved through programming of the rumen microbiome. Thus, understanding maternal influences on the development of the calf rumen microbiome is critical. We hypothesized that there exists a shared microbial profile between the cow and calf rumen microbiomes from birth through weaning. Specifically, our objective was to relate the calf’s meconium and rumen fluid microbiomes in early life to that of the cow rumen fluid prior to parturition and at weaning. Rumen fluid was collected from multiparous Angus crossbred cows (n = 10) prior to parturition and at weaning. Immediately following the parturition, meconium and rumen fluid were collected from the calf. Rumen fluid was collected again from the calf on day 2, day 28, and at weaning. The rumen fluid microbial profile and subsequent volatile fatty acid (VFA) profile were characterized using 16S rRNA sequencing and gas liquid chromatography, respectively. Microbial data was analyzed using QIIME2 and the GLM procedure of SAS was used to analyze the VFA profile. Alpha diversity was similar in the early gut microbiome (meconium, rumen fluid at birth and day 2; q ≥ 0.12) and between the cow and calf at weaning (q ≥ 0.06). Microbial composition, determined by beta diversity, differed in the early rumen microbiome (rumen fluid at birth, day 2, and day 28; q ≤ 0.04), and VFA profiles complimented these results. There were similarities in composition between meconium, rumen fluid at birth, and rumen fluid from the cow at weaning (q ≥ 0.09). These data indicate successive development of the rumen microbiome and stabilization over time. Similarities between meconium and rumen fluid at birth potentially indicates in utero colonization of the calf gastrointestinal tract. Similarities in composition between the early calf rumen microbiome and the cow at weaning prompt an interesting comparison and area for future consideration in terms of identifying at what stage of gestation might colonization begin. Overall, this study provides insight into similarities between the cow and calf microbiomes and may be helpful in developing hypotheses for the pathway of colonization and programming potential in the early gut.
TOC estimation of shale oil reservoir by combining nuclear magnetic resonance logging and nuclear physics logging
Authors: Feng Ziyan , Feng Cheng , Zhong Yuntao , Qin Zhijun , Mao Rui , Zhao Lei , Zong Xianghua 
Published: August 2022

Abstract
The evaluation of source rock properties has become a vital step in logging interpretation. Total organic carbon (TOC) content is the key to estimating the quality and hydrocarbon generation potential of source rocks. In the shale oilfield of the Junggar Basin, the conventional method of calculating the TOC of hydrocarbon source rocks cannot satisfy logging evaluation requirements. This paper predominantly deals with a method for the quantitative estimation of TOC in source rocks via nuclear physics and nuclear magnetic resonance (NMR) logs. According to this method, the total hydrogen index of the source rock is the sum of the response of kerogen, clay minerals and fluid, expressed by corrected neutron porosity. The hydrogen index of fluid and clay minerals is indicated by the effective porosity of NMR and the estimated clay content, respectively. To eliminate the hydrogen index of fluid, the effective NMR porosity is subtracted from the corrected neutron porosity. On this basis, a new and overlapping method suitable for clay-rich rocks and oil reservoirs is proposed. This method was developed by overlaying the scaled clay content curve on the hydrogen index curve. In non-source rocks, the two curves regularly overlap. However, in organic-rich rocks the two curves will separate. The separation distance between the two curves was used to estimate TOC continuously. Possessing sound application and benefiting from the measured results of sweet spots, this method provides new insights for TOC quantitative prediction in shale oil reservoirs.