bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trauernde Kinder und Jugendliche psychologisch begleiten
Authors: Bobillier Franziska 
Published: March 2022

Das Thema Tod und Trauer ist besonders im Umgang mit Kindern und Jugendlichen ein großes Tabuthema. Franziska Bobillier liefert mit diesem Handbuch eine theoretisch fundierte, praxisnahe und anwendungsorientierte Unterstützung für Psycholog*innen, die Kinder, Jugendliche und ihre Eltern im Kontext von Tod und Trauer begleiten.
Die Autorin fokussiert auf folgende Themen:

•	Pathologisierung der Trauer (Diskussion der Diagnose „anhaltende Trauerstörung“ u.v.m.)
•	entwicklungspsychologische Aspekte (Entwicklung des Todeskonzepts, mögliche Trauerreaktionen u.v.m.)
•	Entwicklung der Trauermodelle
•	Konkrete Implementierung des Dualen Prozessmodells (DPM) nach Stroebe und Schut in die kinder- und jugendpsychologische Trauerbegleitung
•	Empfehlungen für unterschiedliche Auftragsarten in der Praxis (Kurz-Coaching von erwachsenen Bezugspersonen: Dos and Donts im Umgang mit trauernden Kindern und Jugendlichen; Empfehlungen für den konkreten Ablauf eines Erstgesprächs u.v.m.)
•	Umgang mit Suizid und Suizidalität (Todeskontext Suizid; Suizidalitätsmanagement: (trauernde) Kinder und Jugendliche coachen)
•	Selbstfürsorge als psychologische Fachperson (u.a. Mindful Self Compassion (MSC) und Acceptance & Commitment Therapy (ACT))
•	Im Anhang befindet sich eine ausführliche Zusammenstellung von Interventionen, Materialien, Checklisten, Musterbriefen, Literaturempfehlungen und Hinweisen auf alternative Angebote, fachliche Weiterbildung und Netzwerkarbeit.
Land Policy for Flood Risk Management—Toward a New Working Paradigm
Authors: Potočki K. , Hartmann T. , Slavíková L. , Collentine D. , Veidemane K. , Raška P. , Barstad J. , Evans R. 
Published: March 2022

AbstractFlood risk management (FRM) aims to integrate necessary technical measures with environmental and societal approaches. Focusing on the process and governance of how to plan, implement, and maintain solutions therefore becomes essential. Among the different stakeholders, landowners are a key group to be considered. This contribution elaborates on the interconnections between land policy, FRM and private land ownership. It is based on the European COST Action network LAND4FLOOD, which brings together academics and stakeholders from various disciplines and more than 35 countries. We argue for a less project oriented and more process oriented approach, a focus on land management and more emphasis on small‐scale measures. This represents a break with some of the recent working paradigms of FRM.
Influence of Data Filters on the Position and Precision of Paleomagnetic Poles: What Is the Optimal Sampling Strategy?
Authors: Gerritsen Dieke , Vaes Bram , van Hinsbergen Douwe J. J. 
Published: March 2022

AbstractTo determine a paleopole, the paleomagnetic community commonly applies a loosely defined set of quantitative data filters that were established for studies of geomagnetic field behavior. These filters require costly and time‐consuming sampling procedures, but whether they improve the precision and influence the position of paleopoles has not yet been systematically analyzed. In this study, we performed a series of experiments on four datasets which consist of 73–125 lava sites with 6–7 samples per lava. The datasets are from different regions and ages, and are large enough to represent paleosecular variation, yet include demonstrably unreliable paleomagnetic directions. We show that the systematic application of data filters based on within‐site scatter (a maximum angular deviation filter on individual directions, a k‐cutoff, a minimum number of samples per site, and eliminating the farthest outliers per site) cannot identify unreliable directions. We find instead that excluding unreliable directions relies on the subjective interpretation of the expert, highlighting the importance of making all data available following the FAIR principles. In addition, data filters that decrease the number of sites even have an adverse effect; they decrease the precision of the paleopole. Between‐site scatter often outweighs within‐site scatter, and when collecting paleomagnetic poles, the extra efforts put into collecting multiple samples per site are more effectively spent on collecting more single‐sample sites.
Predicting the Distribution of Arsenic in Groundwater by a Geospatial Machine Learning Technique in the Two Most Affected Districts of Assam, India: The Public Health Implications
Authors: Nath Bibhash , Chowdhury Runti , Ni‐Meister Wenge , Mahanta Chandan 
Published: March 2022

AbstractArsenic (As) is a well‐known carcinogen and chemical contaminant in groundwater. The spatial heterogeneity in As distribution in groundwater makes it difficult to predict the location of safe areas for tube well installations, consumption, and agriculture. Geospatial machine learning techniques have been used to predict the location of safe and unsafe areas of groundwater As. We used a similar machine learning technique and developed a habitation‐level (spatial resolution 250 m) predictive model to determine the risk and extent of As >10 μg/L in groundwater in the two most affected districts of Assam, India, with an aim to advise policymakers on targeted interventions. A random forest model was employed in Python environments to predict the probabilities of As at concentrations >10 μg/L using intrinsic and extrinsic predictor variables, which were selected for their inherent relationship with As occurrence in groundwater. The relationships between predictor variables and proportions of As occurrences >10 μg/L follow the well‐documented processes leading to As release in groundwater. We identified potential As hotspots based on a probability of ≥0.7 for As >10 μg/L, including regions not previously surveyed and extending beyond previously known As hotspots. Of the total land area (6,500 km2), 25% was identified as a high‐risk zone, with an estimated 155,000 people potentially consuming As through drinking water or cooking food. The ternary hazard probability map (showing high, moderate, and low risk for As >10 μg/L) could inform policymakers on establishing newer drinking water treatment plants and providing safe drinking water connections to rural households.
Temporal Evolution of Low‐Latitude Plasma Blobs Identified From Multiple Measurements: ICON, GOLD, and Madrigal TEC
Authors: Park Jaeheung , Huang Chao‐Song , Eastes Richard W. , Coster Anthea J. 
Published: March 2022

AbstractLow‐latitude plasma blobs have been studied since their first being reported in 1986. However, investigations on temporal evolution of a blob or on continental scale (>2,000 km) ionospheric contexts around it are relatively rare. Overcoming these limitations can help elucidate the blob generation mechanisms. On 21 January 2021, the Ionospheric Connection Explorer satellite encountered a typical low‐latitude blob near the northeastern coast of South America. The event was collocated with a local enhancement in 135.6 nm nightglow at the poleward edge of an equatorial plasma bubble (EPB), as observed by the Global‐scale Observations of the Limb and Disk (GOLD) imager. Total electron content maps from the Global Navigation Satellite System confirm the GOLD observations. Unlike typical medium‐scale traveling ionospheric disturbances (MSTIDs), the blob had neither well‐organized wavefronts nor moved in the southwest direction. Neither was the blob a monotonically decaying equatorial ionization anomaly crest past sunset. Rather, the blob varied following latitudinal expansion/contraction of EPBs at similar magnetic longitudes. The observational results support that mechanisms other than MSTIDs, such as EPBs, can also contribute to blob generation.
ULF Fluctuation of Low‐Latitude Ionospheric Electric Fields During Sudden Commencements
Authors: Zhang Ruilong , Liu Libo , Chen Yiding , Le Huijun , Zhang Hui 
Published: March 2022

AbstractWe use the C/NOFS satellite observations to provide the direct evidence for ultra‐low‐frequency (ULF) fluctuations in the low‐latitude ionospheric electric field during the sudden commencement (SC) on 8 March 2012. The meridional plasma drift shows a sudden downward motion with a large amplitude after SC onset. This initial westward electric field signature is followed by ULF fluctuations with periods of 28–100 s. Further, C/NOFS observations show that the ionospheric zonal electric field and compressional component of geomagnetic field present the similar ULF fluctuations with a ∼90° phase difference, indicating the existence of a standing compressional mode wave. The fluctuations in the ionospheric electric field and horizontal component of the geomagnetic field on the ground also exhibit a high correlation and the frequency of the ground‐based geomagnetic field shows no dependence with latitudes. These results suggest that the ULF waves in the ionospheric electric field may be associated with a cavity mode. We also show the ULF waves in ionospheric electric fields in other cases. The ULF wave electric fields provide important information on the ionospheric studies and ionosphere‐magnetosphere coupling in low latitudes.
Tracking the Spatio‐Temporal Evolution of Foreshocks Preceding the Mw 6.1 2009 L’Aquila Earthquake
Authors: Cabrera Leoncio , Poli Piero , Frank William B. 
Published: March 2022

AbstractHow faulting processes lead to a large earthquake is a fundamental question in seismology. To better constrain this pre‐seismic stage, we create a dense seismic catalog via template matching to analyze the precursory phase of the Mw 6.1 L’Aquila earthquake that occurred in central Italy in 2009. We estimate several physical parameters in time, such as the coefficient of variation, the seismic moment release, the effective stress drop, and analyze spatio‐temporal patterns to study the evolution of the sequence and the earthquake interactions. We observe that the precursory phase experiences multiple accelerations of the seismicity rate that we divide into two main sequences with different signatures and features: the first part exhibits weak earthquake interactions, quasi‐continuous moment release, slow spatial migration patterns, and a lower effective stress drop, pointing to aseismic processes. The second sequence exhibits strong temporal clustering, fast seismicity expansion, and a larger effective stress drop typical of a stress transfer process. We interpret the differences in seismicity behaviors between the two sequences as distinct physical mechanisms that are controlled by different physical properties of the fault system. We conclude that the L’Aquila earthquake is preceded by a complex preparation, made up of different physical processes over different time scales on faults with different physical properties.
Fuel Loads and Plant Traits as Community‐Level Predictors of Emergent Properties of Vulnerability and Resilience to a Changing Fire Regime in Black Spruce Forests of Boreal Alaska
Authors: Grzesik E. J. , Hollingsworth T. N. , Ruess R. W. , Turetsky M. R. 
Published: March 2022

AbstractBlack spruce forest communities in boreal Alaska have undergone self‐replacement succession following low‐to‐moderate severity fires for thousands of years. However, recent intensification of interior Alaska's fire regime, particularly deeper burning of the soil organic layer, is leading to shifts to deciduous‐dominated successional pathways, resulting in many socioecological consequences. Both fuel load quantity and quality (or “burnability”) influence black spruce plant communities' potential to burn. Even relatively low fuel loads, such as those seen in black spruce forest understory, can be highly influential drivers of fire behavior due to their high flammability. Additionally, black spruce community self‐replacement following fire can be largely attributed to the suite of functional and life history traits possessed by the species dominating these communities. We used fuel load (quantity and quality) and amount of within‐population plant trait variation (coefficient of variation; CV) as community‐level emergent properties to investigate black spruce forest vulnerability and resilience to a changing fire regime across the landscape. Our burn severity potential index (BSPI), calculated from fuel load quantity and quality measurements, indicates that drier, higher elevation stands with thicker active layers were the most vulnerable to fire‐induced vegetation shifts under a changing fire regime. Forest resilience to fire‐induced vegetation shift, represented by higher CV, was negatively associated with BSPI and greatest in ecoregions dominated by lowland black spruce forests. Together, these analyses provide critical information for determining the likelihood of stand‐replacing shifts in dominant vegetation following fire and for implementing appropriate ecosystem management practices.
Physical Circulation in the Coastal Zone of a Large Lake Controls the Benthic Biological Distribution
Authors: Girihagama Lakshika , Howell E. Todd , Li Jingzhi , Wells Mathew G. 
Published: March 2022

AbstractGradients of conductivity and major ions in the coastal zone of the eastern Georgian Bay of Lake Huron appear to limit the spatial distribution of invasive dreissenid mussels. Rivers flowing into Georgian Bay from the Canadian Shield have relatively low conductivity compared to the main body of Lake Huron, which creates a gradient of solutes near the river mouths. Field observations show a strong positive correlation between conductivity and calcium concentration. Thus, we use conductivity to infer the calcium concentrations required for the successful growth of dreissenid mussels. Most dreissenid mussels were observed in regions where specific conductivities were greater than 140 μS/cm. Field observations were used to examine how the calcium poor river water mixes within the coastal zone, resulting in solute gradients that determine mussel distribution. When river flows are low in late summer, there is only a weak solute gradient across the coastal zone, implying an intrusion of open bay waters into the shallow embayments, that favor the growth of dreissenid mussels. In contrast, during spring when river flows are as much as 10 times higher, there is a strong solute gradient that extends further into the lake, and the low calcium appears to limit the growth of dreissenid mussels. Thus, the seasonal character of solute gradients helps describe the spatial distribution of dreissenid mussels and explains the localized absence of a species that is otherwise prevalent in much of the Laurentian Great Lakes.
Cancer incidence in healthy Swedish peripheral blood stem cell donors
Authors: Pahnke Simon , Nygell Ulla Axdorph , Johansson Jan-Erik , Kisch Annika , Ljungman Per , Sandstedt Anna , Hägglund Hans , Larfors Gunnar 
Published: March 2022

AbstractGranulocyte colony-stimulating factor (G-CSF) has been used for over 20 years to obtain peripheral blood stem cells from healthy donors for allogeneic stem cell transplantation. Concerns have been raised about a potentially increased cancer incidence in donors after donation, especially regarding haematological malignancies. In a prospective Swedish national cohort study, we studied the cancer incidence after donation in 1082 Swedish peripheral blood stem cell donors, donating between 1998 and 2014. The primary objective was to evaluate if the cancer incidence increased for donors treated with G-CSF. With a median follow-up time of 9.8 years, the incidence of haematological malignancies was 0.85 cases per 1000 person-years, and did not significantly differ from the incidence in age-, sex- and residence-matched population controls (hazard ratio 1.70, 95% confidence interval (CI) 0.79–3.64,pvalue 0.17), bone marrow donors or non-donating siblings. The total cancer incidence for peripheral blood stem cell donors was 6.0 cases per 1000 person-years, equal to the incidence in matched population controls (hazard ratio 1.03, 95% CI 0.78–1.36,pvalue 0.85), bone marrow donors or non-donating siblings. In this study of healthy peripheral blood stem cell donors, the cancer incidence was not increased after treatment with G-CSF.
Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog
Authors: Zhang Qiang , Balourdas Dimitrios-Ilias , Baron Bruno , Senitzki Alon , Haran Tali E. , Wiman Klas G. , Soussi Thierry , Joerger Andreas C. 
Published: March 2022

AbstractThe extremophile Alvinella pompejana, an annelid worm living on the edge of hydrothermal vents in the Pacific Ocean, is an excellent model system for studying factors that govern protein stability. Low intrinsic stability is a crucial factor for the susceptibility of the transcription factor p53 to inactivating mutations in human cancer. Understanding its molecular basis may facilitate the design of novel therapeutic strategies targeting mutant p53. By analyzing expressed sequence tag (EST) data, we discovered a p53 family gene in A. pompejana. Protein crystallography and biophysical studies showed that it has a p53/p63-like DNA-binding domain (DBD) that is more thermostable than all vertebrate p53 DBDs tested so far, but not as stable as that of human p63. We also identified features associated with its increased thermostability. In addition, the A. pompejana homolog shares DNA-binding properties with human p53 family DBDs, despite its evolutionary distance, consistent with a potential role in maintaining genome integrity. Through extensive structural and phylogenetic analyses, we could further trace key evolutionary events that shaped the structure, stability, and function of the p53 family DBD over time, leading to a potent but vulnerable tumor suppressor in humans.
Reducing N6AMT1-mediated 6mA DNA modification promotes breast tumor progression via transcriptional repressing cell cycle inhibitors
Authors: Chen Jiongyu , Zhuang Yixuan , Wang Ping , Ning Jinfeng , Liu Wei , Huang Yiteng , Lin Xueqiong , Peng Lin , Zhang Donghong 
Published: March 2022

AbstractDNA N6-methyladenosine (6mA) is a novel epigenetic signaling modification in humans and has been implicated in the progression and tumorigenesis of several cancers. However, the function and mechanism of 6mA in breast cancer (BC), the most common cancer among women, are unclear. Here, we found that decreases in N6AMT1 correlated with the extent of 6mA in clinical BC tissues and predicted a worse survival of BC patients. Functionally, knockdown of N6AMT1 markedly reduced 6mA in DNA and promoted colony formation and migration of BC cells, whereas overexpression of N6AMT1 had the opposite effect. Moreover, silencing of N6AMT1 reduced 6mA modification and enhanced the growth of BC cells in vitro and tumors in vivo. 6mA immunoprecipitation sequencing (6mA-IP-seq), RNA-seq, 6mA-IP-PCR, and bioinformatics analysis indicated that N6AMT1 was a functional methyltransferase for genomic 6mA DNA modifications and related to gene transcriptional activity. Critical negative regulators of the cell cycle, such as RB1, P21, REST, and TP53 were identified as targets of N6AMT1 in BC. These results suggest N6AMT1 enhances DNA 6mA levels to repress tumor progression via transcriptional regulation of cell cycle inhibitors.
Self-attenuating adenovirus enables production of recombinant adeno-associated virus for high manufacturing yield without contamination
Authors: Su Weiheng , Patrício Maria I. , Duffy Margaret R. , Krakowiak Jakub M. , Seymour Leonard W. , Cawood Ryan 
Published: March 2022

AbstractRecombinant adeno-associated virus (rAAV) shows great promise for gene therapy, however scalability, yield and quality remain significant issues. Here we describe an rAAV manufacturing strategy using a ‘helper’ adenovirus that self-inhibits its major late promoter (MLP) to truncate its own replication. Inserting a tetracycline repressor (TetR) binding site into the MLP and encoding the TetR under its transcriptional control allowed normal adenovirus replication in the presence of doxycycline but only genome amplification and early gene expression (the ‘helper’ functions) in its absence. Using this self-inhibiting adenovirus we demonstrate delivery of adenoviral helper functions, AAV rep and cap genes, and the rAAV genome to yield up to 30-fold more rAAV vectors compared to the helper-free plasmid approach and significant improvements in particle infectivity for a range of serotypes. This system allows significant improvements in the production of serotypes rAAV2, rAAV6, rAAV8 and rAAV9, and enables propagation of existing rAAV without transfection, a process that improves batch quality by depleting reverse packaged DNA contaminants. We propose this as a high-yielding, contaminant-free system suitable for scalable rAAV manufacture.
Observation of the non-linear Meissner effect
Authors: Wilcox J. A. , Grant M. J. , Malone L. , Putzke C. , Kaczorowski D. , Wolf T. , Hardy F. , Meingast C. , Analytis J. G. , Chu J.-H. , Fisher I. R. , Carrington A. 
Published: March 2022

AbstractA long-standing theoretical prediction is that in clean, nodal unconventional superconductors the magnetic penetration depth λ, at zero temperature, varies linearly with magnetic field. This non-linear Meissner effect is an equally important manifestation of the nodal state as the well studied linear-in-T dependence of λ, but has never been convincingly experimentally observed. Here we present measurements of the nodal superconductors CeCoIn5 and LaFePO which clearly show this non-linear Meissner effect. We further show how the effect of a small dc magnetic field on λ(T) can be used to distinguish gap nodes from non-nodal deep gap minima. Our measurements of KFe2As2 suggest that this material has such a non-nodal state.
Increasing terrestrial ecosystem carbon release in response to autumn cooling and warming
Authors: Tang Rui , He Bin , Chen Hans W. , Chen Deliang , Chen Yaning , Fu Yongshuo H. , Yuan Wenping , Li Baofu , Li Zhi , Guo Lanlan , Hao Xingming , Sun Liying , Liu Huiming , Sun Cheng , Yang Yang 
Published: March 2022

AbstractPart of the Northern Hemisphere has experienced widespread autumn cooling during the most recent decades despite overall warming, but how this contrasting temperature change has influenced the ecosystem carbon exchange remains unclear. Here, we show that autumn cooling has occurred over about half of the area north of 25° N since 2004, producing a weak cooling trend over the period 2004–2018. Multiple lines of evidence suggest an increasing net CO2 release in autumn during 2004–2018. In cooling areas, the increasing autumn CO2 release is due to the larger decrease of gross primary productivity (GPP) growth than total ecosystem respiration (TER) growth suppressed by cooling. In the warming areas, TER increased more than GPP because the warming and wetting conditions are more favourable for TER growth than GPP increase. Despite the opposite temperature trends, there has been a systematic increase in ecosystem carbon release across the Northern Hemisphere middle and high latitudes.