bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complicações e repercussões da COVID-19 na pediatria
Authors: Sardinha Ingrid Jordana B F , Mascarenhas Isabella Tempone , Ribeiro Karolina Louzada , Candido Stephanie de Souza , Santos Anna Izabel Alves da Silva , Bueno Karina Franco , Rabelo Raysa Queiroz 
Published: October 2022

Atualmente enfrenta-se a pandemia do COVID- 19, doença desconhecida que se espalhou rapidamente e exigiu tratamentos eficazes. Na pediatria observou que crianças eram afetadas mais raramente e de forma leve quando comparadas aos adultos. Diante das hipóteses levantadas para explicar esse fenômeno acredita-se na relação entre a enzima conversora de angiotensina 2 (ACE2) nas células epiteliais alveolares do tipo I e II. A ACE2 é o receptor do SARS-CoV-2, fundamental para a entrada na célula hospedeira e logo na replicação do vírus na infância há uma expressão limitada da ACE2, devido os pulmões ainda estarem em desenvolvimento, resultando em proteção. Homens têm níveis mais altos de ACE2 em suas células alveolares em comparação às mulheres, o que explica o maior número de mortes no sexo masculino e predisposição, quando comparado as crianças nas taxas de hospitalização entre meninas e meninos. No Reino Unido e posteriormente na Europa e EUA foram identificadas crianças com manifestações da síndrome inflamatória multissistêmica (MIS-C). Apresentaram choque hiperinflamatório semelhantes à doença de Kawasaki e à síndrome do choque tóxico além de febre, sinais de inflamação generalizada, hipotensão e disfunção de múltiplos órgãos.
HEAT AND DROUGHT FORBEARING, UPLAND COTTON (GOSSYPIUM HIRSUTUM L.) VARIETY; RH-668 FOR CULTIVATION IN SEMI-ARID REGION
Authors: MASOOD SA , KHALIQ A , RAUF HA , MAHMOOD K , AHMED I , HUSSAIN N , KANWAL S , FAHEEM U , MUHAMMAD T 
Published: October 2022

Cotton variety: RH-668, produced by Cotton Research Institute, Khanpur, holds excessive tolerance against dry climatic stipulations and maintains superior fiber personae.Parental combination;VH-259 × RH-620 was used in hybridization followed by Pedigree method of selection to extract uniform genotypes with superior phenotypes. These superior plantswere then tested for yield under drought stress at station level before competing atseries of adaptability trials in Punjab followed by provincialand national coordinated varietal trials in the course of 2013-2018. Due to governance incorporated by tolerance against heat & drought it outperformed others at various climatic conditions countrywide for yield and fiber linked characters in opposition to the Standards varieties FH-142 &CIM-602. In Provincial (PCCT) and National level(NCVT) it gave 29.0% & 8.8%, respectively more yield when compared to check variety; FH-142. Hence, Accredited by seed Council, Punjab in 2018 for generic cultivation with 39.4 Ginning outturn percentage, 4.5 micronaire value, staple length of 28.78 (mm) and seed-cotton yield prospectiveper acre ofsixty twomounds.Due to fruiting from lower nodes; erect root development, Brittle leaf surface, lesser shedding of fruiting structures and protracted sympods with bead like bolls arrangement, it deliberately tolerates heat stress.
Evaluación y pronóstico de muerte en pacientes obesos con ventilación mecànica.
Authors: Campoverde Espinoza Rafael Agripino , Vargas Olalla Vanessa Paulina , Correa Muñiz Luz Susana 
Published: October 2022

a obesidad es un problema de salud pública, causado por los malos hábitos alimenticios, es un factor que puede complicar el manejo de los pacientes que presentan problemas respiratorios, en especial si requieren apoyo de ventilación mecánica invasiva, este problema se evidencia especialmente en los últimos tiempos en que se han incrementado el número de pacientes por la pandemia.
Objetivo: Determinar la influencia de la obesidad en la evaluación de mortalidad en pacientes sometidos a ventilación mecánica invasiva.
Material y Método: Se realizó un estudio en los pacientes del área de terapia intensiva del Hospital Luis Vernaza ingresados en el periodo desde marzo 2020 hasta marzo 2021 entre las edades de 16 y 90 años. Se utilizó las historias clínicas digitalizadas del programa SERVINTER CLINICAL SUITE (HC MEDICA – 2.6) – (Evolución Médica – 2.6.2 (chievomed)
Conclusión: Los resultados reflejaron que la mayoría de los pacientes fueron personas adultas mayores y del género masculino así también Una de las características clínico epidemiológicas más comunes fue la disnea. En los resultados correlaciónales se encontró que las características clínico epidemiológicas y el IMC se relacionan estadísticamente con la mortalidad después de usar Ventilación Mecánica Invasiva (VMI), existe influencia entre el sobrepeso, la obesidad y la mortalidad.
EFEKTIFITAS PEMBELAJARAN PADA PELATIHAN JARAK JAUH ILMU PENGETAHUAN ALAM MADRASAH TSANAWIYAH ANGKATAN 2 DENGAN MENGUNAKAN MODEL ADDIE
Authors: Nurdin Saeful 
Published: October 2022

Penelitian ini bertujuan untuk mengetahui efektifitas pembelajaran pada pelatihan jarak jauh guru IPA Madrasah Tsanawiyah Angkatan 2. Metode yang digunakan metode kuantitatif deskriftif dan jenis penelitian pengembangan. Penelitian ini diadaptasi dari Pengembangan model ADDIE yang tiga tahap 1. Pemodelan, terdiri dari analisis, dan desain pembelajaran; tahap 2. Pengembangan, terdiri dari pengembangan konten dan pengembangan produksi video pembelajaran; dan tahap 3. Implementasi, terdiri dari implementasi materi esensial dan media lab virtual serta evaluasi.. Angkatan 2 yang telah lulus seleksi sebanyak 38 orang. Efektifitas pemahaman kognitif terhadap konten pelatihan jarak jauh IPA MTs Angkatan 2 dengan nilai tertinggi 100 dan tertendah 57,50 serta rata-rata kelas 83,16. Pengembangan Pelatihan PJJ IPA MTs Angkatan 2 dengan kursil yang baru dapat tercapai dengan efektif melalui model pengembangan ADDIE
PENERAPAN BINA DIRI DENGAN TEKNIK MODELLING UNTUK MENINGKATKAN PERILAKU ADAPTIF SISWA KELAS VIII C SEKOLAH LUAR BIASA YPPABK NGAWI
Authors: Setyowati Eny , Solekah Anisah Binti Solekah , Pratiwi Resa Andi 
Published: October 2022

ABSTRACT This research is written to increase effectiveness tunagrahita learning activities in VIII C YPP ABK Ngawi can behave adaptive behavior and leave non adaptive. The kind of research used is case study, that is a discriptive and analysis a specified phenomenon social as individual or unit, group an intitution or community. The implementation of a development modelling to facilitate students in understanding and practice material provided by teacher making it the adaptive students behavior seen from the behavior changes and attitudes interact social students in all teachers or by part of his class, they didn’t even conduct behavior non adaptive as before.
Keywords : Self development, modelling technique, adaptive behavior
Identificación de las contribuciones de las mipymes a la competitividad territorial: análisis de dos actividades económicas en Cauca, Colombia
Authors: Sánchez Tróchez Diana Ximena , Potes Ordoñez Laura Beatriz , De la Torre Solarte Gabriel , Rivera Martínez Wilfred Fabián 
Published: October 2022

Objetivo: este artículo analiza las dinámicas empresariales de dos actividades económicas representativas de la economía nacional como lo son la manufactura y la construcción a fin de identificar la perspectiva empresarial y el análisis del entorno general, elementos relevantes en el tejido empresarial que inciden en las mediciones de competitividad.
Metodología: Para lograr este propósito se diseñó una metodología mixta que aplicó encuestas y entrevistas semiestructuradas a 146 empresas representativas de estos sectores en el departamento del Cauca, en el sur-occidente colombiano.
Resultados: entre los hallazgos de mayor relevancia se encuentran las variables que inciden en la perspectiva empresarial y los elementos del entorno en los que se desempeñan estas empresas como la fuente primaria de elementos, cuya gestión precisa de mayor atención por parte de agencias estatales y organizaciones de apoyo empresarial a fin de contribuir al mejoramiento de la competitividad en el ámbito territorial.
Limitaciones: se presentan dificultades en el trabajo de campo, debido a las exigentes medidas de bioseguridad de las organizaciones por la emergencia sanitaria del covid 19, extendiendo los tiempos de ejecución previstos inicialmente.
Implicaciones prácticas: el estudio es de utilidad en áreas de direccionamiento estratégico y gestión empresarial, promoviendo el fortalecimiento del tejido empresarial a partir de la formación de empresarios con una visión prospectiva según los requerimientos del contexto, siendo extrapolable incluso a otros sectores económicos.
De qué hablamos cuando hablamos de diseño
Authors: Lavernia Nacho 
Published: October 2022

El diseño se está convirtiendo en el método que aplicar para buscar soluciones a lospequeños y grandes problemas económicos, empresariales, sociales omedioambientales, que un mundo en crisis profunda está provocando. De hecho, supráctica se está expandiendo y en los últimos tiempos han surgido especialidades comoel diseño de servicios, el diseño social, el diseño de experiencias o el design thinking.Esta dispersión del diseño hace difícil definirlo y pone en duda de qué hablamos cuandohablamos de diseño. El propósito de este artículo es compartir una definición del diseñobasada en tres características de la disciplina que parecen comunes también a estasnuevas especialidades: una actitud creativa; capacidad expresiva, y trabajar siempre enla relación entre los objetos y las personas. Tres cualidades que nos caracterizan y, a lavez, nos diferencian de otro tipo de profesionales como ingenieros o artistas.
Metal‐Free Rapid Sulfonylation of para‐Quinone Methides and N‐Arylmaleimides with Sulfonyl Hydrazides via a Free‐Radical Pathway
Authors: Gairola Deepti , Peddinti Rama Krishna 
Published: October 2022

AbstractMetal‐free oxidative sulfonylation strategy for the direct incorporation of sulfonyl units to access 3‐sulfonyl succinimides, diarylmethyl sulfones and diarylsulfones via a free‐radical pathway under aerobic conditions in aqueous media has been developed. Using easily accessible sulfonyl source, this methodology proceeds efficiently with a high degree of functional group compatibility under operationally simple reaction conditions. In this novel transformation with moderate to excellent yield, a green reaction system is established without the risk of metal contamination and inert atmosphere at room temperature. Mechanistic investigations revealed that sulfonyl radicals could be generated in situ from sulfonyl hydrazides in the presence of I2/TBHP under aerobic conditions.
Conversion of a AuI Fluorido Complex into an N‐Fluoroamido Derivative: N−F versus Au−N Reactivity
Authors: Rachor Simon G. , Ahrens Mike , Braun Thomas 
Published: October 2022

AbstractThe AuI complex [Au{N(F)SO2Ph}(SPhos)] (SPhos=dicyclohexyl(2′,6′‐dimethoxy[1,1′‐biphenyl]‐2‐yl)phosphane) (2) bearing a fluoroamido ligand has been synthesized by reaction of the fluorido complex [Au(F)(SPhos)] (1) with NFSI (NFSI=N‐fluorobenzenesulfonimide). A reaction with CO resulted in an unprecedented insertion into the N−F bond at 2. With the carbene precursor N2CH(CO2Et) N−F bond cleavage gave the Au−F bond insertion product [Au{CHF(CO2C2H5)}(SPhos)] (7). The presence of CNtBu led to Au−N cleavage at 2 and concomitant amide formation to give the cationic complex [Au(CNtBu)(SPhos)][N(F)SO2Ph)] (5), which reacted further to give FtBu as well as the cyanido complex [Au(CN)(SPhos)] (6). These results led to the development of a process for the amination of electrophilic organic substrates by transfer of the fluoroamido group NF(SO2Ph)−.
How people deal with …............................ outliers
Authors: Dannals Jennifer E. , Oppenheimer Daniel M. 
Published: October 2022

AbstractPeople regularly make sense of distributions that are complicated by noise. How do individuals determine whether an outlying observation should be incorporated into one's understanding of the true distribution of the population or considered a fluke that ought to be disregarded? In a simple prediction task, we examine how individuals incorporate outliers and compare their behavior to various prescriptive models (e.g., averaging and tests of discordancy). We find that, on average, individuals do discount outlying values and that their outlier detection strategies approximate approaches that statisticians have recommended for Gaussian distributions, even when the observed distributions are not Gaussian. However, there are notable differences in treatment of outliers across individuals.
Enzyme Engineering Enables Inversion of Substrate Stereopreference of the Halogenase WelO5*
Authors: Voss Moritz , Hüppi Sean , Schaub Daniela , Hayashi Takahiro , Ligibel Mathieu , Sager Emine , Schroer Kirsten , Snajdrova Radka , Buller Rebecca 
Published: October 2022

AbstractEnzymatic late‐stage diversification of small molecules has the potential to rapidly generate diversity in compound libraries dedicated to drug discovery. In this context, freestanding Fe(II)/α‐ketoglutarate‐dependent halogenases have raised particular interest as this enzyme family allows the otherwise difficult regio‐ and stereoselective halogenation of unactivated C(sp3)−H bonds. Here, we report the development of two engineered variants of the halogenase WelO5* for the racemic resolution of a mixture of stereoisomers generated in the synthesis of a bioactive martinelline‐derived fragment. By screening a 3‐site combinatorial variant library, we could identify two variants exhibiting exquisite substrate selectivity towards the desired enantiomers. Strikingly, the inversion of substrate stereopreference between the halogenase variants was achieved by varying only three residues in the active site. Protein crystallization and subsequent structure elucidation of the wildtype enzyme and a WelO5* variant shed light on the factors governing substrate acceptance and selectivity.
Photoredox Csp3−Csp2 Reductive Cross‐Couplings of Cereblon Ligands for PROTAC Linker Exploration in Batch and Flow
Authors: Steiner Alexander , Krieger Johannes , Jones Reinaldo , Böse Dietrich , Wang Yanping , Eggenweiler Hans‐Michael , Williams Jason D. , Kappe C. Oliver 
Published: October 2022

AbstractProteolysis‐targeting chimeras (PROTACs) have recently emerged as powerful molecules for targeted protein degradation. As such, synthetic methods for their modular synthesis are of prime importance in medicinal chemistry. We report the development of both batch and flow photoredox methodologies for Csp3−Csp2 cross‐electrophile couplings of alkyl bromides with E3 ligase‐binding aryl bromides (thalidomide and lenalidomide derivatives). Despite the challenging reaction system, containing several insoluble species, conditions were discovered to facilitate stable processing in an oscillatory flow photochemical reactor. The flow approach can enable processing of larger material quantities in a shorter time period. A range of saturated linker molecules, with various functional handles, were successfully combined with four ligand variants using the developed conditions. Finally, scalability in batch and use of an organic photocatalyst were explored.
Improved constant phase fractional order approximation method for induction motor FOPI speed controller
Authors: Adigintla Sudheer , Aware Mohan V. 
Published: October 2022

SummaryThis paper presents the digital realization of the fractional‐order PI (FOPI) controller fractional integrator element using the improved constant phase approximation method. A new pole‐zero rationalization approach is proposed within the bandwidth of the Bode phase plot. The voltage source inverter fed induction motor fractional‐order model has been identified. A novel mathematical FOPI controller design procedure for the identified FO plant model has been proposed. The designed FOPI controller fractional integrator element is implemented using the constant phase approximation method. A detailed comparative performance study of the proposed approximation method with the existing Charef, Oustaloup, and refined Oustaloup methods has been carried out using the Bode, Nyquist, and Nichols plots. The proposed FOPI controller is placed in the speed feedback loop of the rotor field‐oriented control algorithm of IM. To confirm the proposed FOPI controller approximation method's robustness, a hardware study is carried out on the laboratory hardware‐in‐loop (HIL) platform. In addition, variation in the number of pole‐zero pair's effect on the speed tracking performance, robustness against parameter and load variations are also analyzed.
Stereoselective Synthesis of the DE Ring Portion of Kadcoccilactone A by a Radical Addition/Cyclization Approach
Authors: Noguchi Kimihiro , Saito Sayuri , Yamakoshi Hiroyuki , Nakamura Seiichi 
Published: October 2022

AbstractA stereoselective synthesis of the DE ring portion of kadcoccilactone A, triterpenoid isolated from Kadsura coccinea, has been achieved starting from a chiral building block, utilizing a photocatalytic decarboxylative addition/cyclization/fragmentation sequence to construct the five‐membered ring and intramolecular alkylation to create the quaternary stereocenter as key steps.
Electrochemical Investigation on Kinetics of Xanthine Metabolism and Inhibition Effect of Febuxostat on Xanthine Oxidase Activity
Authors: Liu Fuxin , Shang Tianyi , Han Lingling , He Nan , Liu Xiuhui 
Published: October 2022

AbstractXanthine is a significant biomolecule and its concentration level in urine and blood plasma is an indicator of specified pathological states. Here, a new sensing platform was designed, which showed excellent analytical performance for xanthine. Importantly, it is the first time to investigate the kinetics of xanthine metabolic reaction by electrochemical method. The results demonstrated that the conversion of xanthine to uric acid completely conformed to the Michaelis‐Menten kinetics. Furthermore, we also studied the inhibitory effect of febuxostat on xanthine oxidase activity detailed. As expected, the work may offer potential value for researchers in the treatment of hyperuricemia and gout.
Electrocatalytic enhancement mechanism of cobalt single atoms anchored on different MXene substrates in oxygen and hydrogen evolution reactions
Authors: Zhao Xin , Zheng Xuerong , Lu Qi , Li Ying , Xiao Fengping , Tang Bing , Wang Shixun , Yu Denis Y. W. , Rogach Andrey L. 
Published: October 2022

AbstractDecorating single atoms of transition metals on MXenes to enhance the electrocatalytic properties of the resulting composites is a useful strategy for developing efficient electrocatalysts, and the mechanisms behind this enhancement are under intense scrutiny. Herein, we anchored Co single atoms onto several commonly used MXene substrates (V2CTx, Nb2CTx and Ti3C2Tx) and systematically studied the electrocatalytic behavior and the mechanisms of oxygen and hydrogen evolution reactions (OER and HER, respectively) of the resulting composites. Co@V2CTx composite displays an OER overpotential of 242 mV and an HER overpotential of 35 mV at 10 mA cm−2 in 1.0 M KOH electrolyte, which is much lower than for Co@Nb2CTx and Co@Ti3C2Tx, making it comparable to the commercial noble metal Pt/C and RuO2/C electrocatalysts. The experimental and theoretical results point out that the enhanced bifunctional catalytic performance of Co@V2CTx benefits from the stronger hybridization between Co 3d and surface terminated O 2p orbitals which optimized the electronic structure of Co single atoms in the composite. This, in turn, results in lowering the OER and HER energy barriers and acceleration of the catalytic kinetics in case of the Co@V2CTx composite. The advantage of Co@V2CTx was further validated by its high overall water splitting performance (1.60 V to deliver 10 mA cm−2). Our study sheds light on the origins of the catalytic activity of single transition metals atoms on MXene substrates, and provides guidelines for designing efficient bifunctional MXene‐based electrocatalysts.image
Who gets mad, sad, scared or happy at discipline? Emotion attributions explain child externalizing behaviour
Authors: de Oliveira Ebenézer A. , Mendes Deise M. L. F. , Pessôa Luciana F. , de M. Oliveira Susana K. 
Published: October 2022

AbstractFew studies have linked parental discipline with children's emotional experiences, and not much data explore children's emotional attributions to discipline linked to externalizing behaviour. With a sample from Brazil, this study examines which emotions children most aptly attribute to a protagonist facing spanking, time‐out or inductive discipline for norm violations. We hypothesized that anger, sadness, and fear would have higher attribution rates at spanking or time‐out, relative to inductive discipline and that happiness would have higher attribution rates at induction relative to the other discipline modalities. We expected these findings to be more pronounced in older children. Based on emotional functions, we also tested the role of neutrality and happiness attributions to discipline in children's externalizing behaviour. A two‐way MANOVA, with discipline and child age as explanatory variables, showed that children attributed more anger at time‐out or spanking than at induction, and more happiness and neutrality at induction than at either time‐out or spanking. Older children attributed significantly more sadness and less fear or neutrality. Hierarchical regressions showed that child externalizing behaviour was negatively related to happy attributions in discipline independently of child emotion situation knowledge or demographics. The results are interpreted in light of a functional view of emotions.
Postdiagnosis recreational physical activity and breast cancer prognosis: Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis
Authors: Cariolou Margarita , Abar Leila , Aune Dagfinn , Balducci Katia , Becerra‐Tomás Nerea , Greenwood Darren C. , Markozannes Georgios , Nanu Neesha , Vieira Rita , Giovannucci Edward L. , Gunter Marc J. , Jackson Alan A. , Kampman Ellen , Lund Vivien , Allen Kate , Brockton Nigel T. , Croker Helen , Katsikioti Daphne , McGinley‐Gieser Deirdre , Mitrou Panagiota , Wiseman Martin , Cross Amanda J. , Riboli Elio , Clinton Steven K. , McTiernan Anne , Norat Teresa , Tsilidis Konstantinos K. , Chan Doris S. M. 
Published: October 2022

AbstractIt is important to clarify the associations between modifiable lifestyle factors such as physical activity and breast cancer prognosis to enable the development of evidence‐based survivorship recommendations. We performed a systematic review and meta‐analyses to summarise the evidence on the relationship between postbreast cancer diagnosis physical activity and mortality, recurrence and second primary cancers. We searched PubMed and Embase through 31st October 2021 and included 20 observational studies and three follow‐up observational analyses of patients enrolled in clinical trials. In linear dose‐response meta‐analysis of the observational studies, each 10‐unit increase in metabolic equivalent of task (MET)‐h/week higher recreational physical activity was associated with 15% and 14% lower risk of all‐cause (95% confidence interval [CI]: 8%‐22%, studies = 12, deaths = 3670) and breast cancer‐specific mortality (95% CI: 4%‐23%, studies = 11, deaths = 1632), respectively. Recreational physical activity was not associated with breast cancer recurrence (HR = 0.97, 95% CI: 0.91‐1.05, studies = 6, deaths = 1705). Nonlinear dose‐response meta‐analyses indicated 48% lower all‐cause and 38% lower breast cancer‐specific mortality with increasing recreational physical activity up to 20 MET‐h/week, but little further reduction in risk at higher levels. Predefined subgroup analyses across strata of body mass index, hormone receptors, adjustment for confounders, number of deaths, menopause and physical activity intensities were consistent in direction and magnitude to the main analyses. Considering the methodological limitations of the included studies, the independent Expert Panel concluded ‘limited‐suggestive’ likelihood of causality for an association between recreational physical activity and lower risk of all‐cause and breast cancer‐specific mortality.