bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Online Facial Exercise and Self-Massage Program on Neck and Head Pain and Quality of Life
Authors: Dapkevičiūtė Medeinė , Žlibinaitė Laura 
Published: January 2022

Background. Due to the COVID-19 pandemic and the lockdown, most people with headache and neck pain were unable to access health care services, so it is unclear which remote physiotherapy methods would be effective in treating neck and head pain.
Aim. To investigate the effects of virtual facial exercise and self-massage on women’s neck and head pain and functional condition.
Methods. The study included 33 women 45–59 years old, who had experienced neck and head pain in the past month and were not taking pain medications. All subjects were in the experimental group. Facial exercise and self-massage for 20 minutes daily for 20 days were performed by the subjects following virtual instructions. Before and after the intervention, the intensity of neck and head pain was assessed using numeric pain intensity scale, the quality of life was assessed using neck disability index and headache disability index.
Results. Neck pain decreased by 3.82 ± 2.63 points (p < 0.05), headache decreased by 2.82 ± 1.93 points (p < 0.05), neck functional disability decreased by 7.33 ± 4.57 points (p < 0.05), headache disability index values decreased by 15.57 ± 8.47 points (p < 0.05).
Conclusion. After the application of virtual facial exercise and self-massage, women’s neck and head pain was reduced and the quality of life improved.
Keywords: neck pain, headache, physiotherapy, massage, quality of life.
A Survey on the Current Status of Ophthalmological Consultations in Patients With Diabetes Undergoing Maintenance Hemodialysis and the Effectiveness of Education on Consultation Behavior –Experience of a Single Hemodialysis Clinic in Japan
Authors: Kimura Moritsugu , Toyoda Masao , Saito Nobumichi , Abe Makiko , Kato Eri , Sugihara Akemi , Ishida Naoto , Fukagawa Masafumi 
Published: January 2022

IntroductionIt is extremely important for patients with diabetes undergoing maintenance hemodialysis (MHD) to receive regular ophthalmologic examinations. However, even in the field of MHD in Japan, where there are many hemodialysis patients and the survival rate is said to be one of the highest in the world, we often see patients with diabetes who do not receive regular ophthalmologic examinations. In this study, we surveyed the status of ophthalmology consultations and the use of diabetic eye notebook (DEN) among hemodialysis patients with diabetes at hemodialysis clinics to confirm the current situation, with the aim of confirming the effectiveness of education on consultation behavior by medical care staff.Materials and MethodsThis study included 38 diabetic hemodialysis patients attending one MHD clinic in Japan for one year from March 2018 to March 2019. In the first fact-finding survey in March 2018, hemodialysis care unit nurses (HCUNs) in the hemodialysis unit asked the diabetic hemodialysis patients whether they had consulted an ophthalmologist and used the DEN. Based on the results, the HCUNs recommended that hemodialysis patients with complications of diabetes be educated about the usefulness of regular ophthalmologic examinations, even during MHD, and that they use the DEN. This was followed by a second fact-finding survey in March 2019 to reconfirm ophthalmology consultations and DEN use.ResultsRegarding the presence of ophthalmology consultations, 22 of 38 (58%) patients had regular ophthalmology consultations in March 2018, and 27 of 38 (71%) patients had consultations in the following year after receiving information from an HCUN. Only 1 of 22 patients (5%) who consulted the ophthalmologist in March 2018 used a DEN, but 19 of 27 patients (70%) used it the following year.ConclusionIn the future, the development and utilization of a new DEN that includes more detailed patient information, and the spread of self-care guidance to patients by multidisciplinary health care professionals, will increase the consultation rate of MHD patients in Japan and reduce the incidence and progression of ocular diseases in MHD patients.
Adjustment of the GRACE Risk Score by Monocyte to High-Density Lipoprotein Ratio Improves Prediction of Adverse Cardiovascular Outcomes in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
Authors: Ma Xiaoteng , Han Kangning , Yang Lixia , Shao Qiaoyu , Li Qiuxuan , Wang Zhijian , Li Yueping , Gao Fei , Yang Zhiqiang , Shi Dongmei , Zhou Yujie 
Published: January 2022

Background and AimsThe monocyte to high-density lipoprotein cholesterol ratio (MHR), a novel marker for inflammation and lipid metabolism, has been demonstrated to be associated with poor prognosis in many patient populations. However, the prognostic influence of MHR in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) is poorly understood. Here, we sought to investigate the relationship between MHR and adverse cardiovascular (CV) outcomes in such patients and determine whether MHR could improve the GRACE risk score based prognostic models.Methods and ResultsMHR was applied to 1,720 patients with ACS undergoing PCI who were admitted to our CV center from June 2016 to November 2017. These patients were stratified into three groups according to MHR tertiles. The relationship between MHR and the primary endpoint (overall death, non-fatal stroke, non-fatal myocardial infarction, or unplanned repeat revascularization) was examined by Cox proportional hazards regression analysis. During a median follow-up of 31 months, 353 patients had at least one primary endpoint event. Compared with those in the lowest MHR tertile, patients in the middle and highest tertiles [adjusted HR: 1.541 (95% CI: 1.152–2.060) and 1.800 (95%CI: 1.333–2.432), respectively], had a higher risk of the primary endpoint. The addition of MHR has an incremental effect on the predictive ability of the GRACE risk score for the primary endpoint (cNRI: 0.136, P &lt; 0.001; IDI: 0.006, P &lt; 0.001).ConclusionMHR was independently and significantly associated with adverse CV outcomes in ACS patients who underwent PCI and improved the predictive ability of the GRACE risk score based prognostic models.Registration Numberhttp://www.chictr.org.cn/hvshowproject.aspx?id=21397; ChiCTR1800017417.
Outcomes of One-Stage Surgical Repair for Berry Syndrome in Neonates
Authors: Shi Xu-Cong , Weng Jian-Bin , Yu Jin , Ma Xiao-Hui , Pu Yi-Qing , Ying Li-Yang , Yu Jian-Gen 
Published: January 2022

BackgroundBerry syndrome is a challenging disease for surgeons to make early diagnosis and successful surgical correction in the neonatal period. Here, we summarized the clinical features of three neonates with berry syndrome in our center to optimize the therapeutic effect in the future.MethodsFrom January 2014 to December 2019, three neonates with berry syndrome underwent one-stage surgical repair in our center. We mainly used two different surgical techniques to repair it, and collected clinical data retrospectively from hospitalization history, outpatient records, and telephone follow-up.ResultsThe age at operation was 28, 8, and 8 days and the body weight was 3.65, 3.86, and 3.0 kg, respectively. The morphology of the interrupted aortic arch (IAA) was type A in two patients and type B in one patient. The aortopulmonary window (APW) morphology was type IIa, III, and IIb, respectively. The phenotype of the IAA type B combined with APW type III in our second patient was reported for the first time so far. All patients survived and were followed up to date. The second patient using intra-aortic baffle experienced twice reoperation for right pulmonary artery (RPA) stenosis. All patients grew well so far.ConclusionOnce diagnosed in the neonatal period, berry syndrome can be safely corrected by one-stage surgical repair in experienced cardiac centers. Considering the variability of the location where the RPA arises from the posterior wall of the aorta, it is difficult to find the best surgical method for each patient.
Paroxetine and Mortality in Heart Failure: A Retrospective Cohort Study
Authors: Xu Hongxuan , Meng Lingbing , Long Huanyu , Shi Yueping , Liu Yunqing , Wang Li , Liu Deping 
Published: January 2022

IntroductionParoxetine is a GRK2 inhibitor that has been widely used to treat depression and anxiety over the last few decades. The inhibition of GRK2 has been studied extensively in vivo; however, evidence of its impact on heart failure remains scarce.MethodsTo assess the association between paroxetine use and mortality in patients with heart failure. We conducted a retrospective longitudinal cohort study from 2008 to 2019, with a follow-up time of 28 days for all groups. This is a single-center study using the Medical Information Mart for Intensive Care IV database with 11,657 heart failure patients identified. We performed genetic matching to adjust for the covariates. Heart failure patients prescribed paroxetine for &gt;24 h after hospital admission were categorized into the paroxetine group (77 patients), with remaining heart failure patients making up the matched control group (231 patients). The primary outcome was 28-day all-cause mortality from the date of hospital admission. Secondary outcomes included length of intensive care unit stay, length of hospital stay, and in-hospital mortality. The Kaplan–Meier survival estimator, logistic regression, Cox regression, and restricted mean survival time were used to detect the association between paroxetine therapy and outcomes.ResultsPatients who received paroxetine during one hospital admission lived, on average, 0.7 lesser days (95% CI −2.53 to 1.1, p = 0.46) than patients who did not use it in a 28-day truncation time point. Multivariable logistic regression, including all matched covariates, demonstrated that the adjusted odds ratio of 28-day mortality of the paroxetine administration group was 1.1 (95% CI 0.37–2.9, p = 0.90). Multivariable Cox regression of 28-day mortality presented an adjusted hazard ratio of 1.00 (95% CI 0.42–2.62, p = 0.92). Paroxetine was associated with an increased survival time at a 3,000-day truncation time point (203 days, 95% CI −305.69 to 817.8, p = 0.37).ConclusionsIn patients with heart failure, treatment with paroxetine did not significantly reduce 28-day all-cause mortality.
Seasonal Amplitude of Water Storage Variations of the Yangtze–Huai Plain Lake Group: Implicaion for Floodwater Storage Capacity
Authors: Song Lijuan , Song Chunqiao , Zhan Pengfei , Chen Tan , Liu Kai , Jing Haitao 
Published: January 2022

Lakes are of significant importance in regulating floods and providing water sources. The seasonal water storage variations for the plain lake group in the Yangtze–Huai River Basin (YHRB) are significant for alleviating flood pressure and regulating runoff. However, to date, the seasonal amplitude of lake water storage variations and its capacity of buffering floodwater in the YHRB is not quantified well and remains to be investigated comprehensively. To advance the understanding of such a critical scientific issue, the water level data of the plain lake group (area&gt;100 km2, 29 lakes) in the YHRB is collected from multi-source data between 1990 and 2020. Using lake inundation area obtained from Global Surface Water and water level variations, water storage dynamics for the plain lake group are quantified. Furthermore, this study also uses the Gravity Recovery and Climate Experiment (GRACE) products to analyze the terrestrial water storage anomalies (TWSA) in the whole basin. The results indicate that the seasonal amplitude of water level change and water storage variation of the plain lake group are 2.80 ± 0.71 m and 37.38 ± 14.19 Gt, respectively. Poyang and Dongting Lakes, two lakes that maintain the natural connection with the Yangtze River, have the most substantial seasonal amplitude in the hydrological situation. The amplitude in water level and water storage in Poyang Lake is 9.53 ± 2.02 m and 14.13 ± 5.54 Gt respectively, and that in Dongting Lake is 7.39 ± 1.29 m and 7.31 ± 3.42 Gt respectively. The contribution of seasonal variation of water storage for large plain lakes to TWSA in the YHRB is approximately 33.25%, fully reflecting these lake’s imperative position in the YHRB. This study is expected to enhance the scientific understanding of the seasonal hydrologic regime for the large lakes in the YHRB and contribute to the management of flood risks and water resources in East China.
BRD4 Inhibition Attenuates Inflammatory Pain by Ameliorating NLRP3 Inflammasome-Induced Pyroptosis
Authors: Hua Tong , Wang Haowei , Fan Xiaoyi , An Ni , Li Jian , Song Honghao , Kong Erliang , Li Yongchang , Yuan Hongbin 
Published: January 2022

Chronic pain, such as persistent inflammatory pain, remains a public health problem that has no effective treatment at present. Bromodomain-containing protein 4 (BRD4) inhibition, induced by JQ1 injection or BRD4 knockdown, has been used to attenuate inflammatory pain; However, it remains elusive whether BRD4 aggravates inflammatory pain by regulating inflammasome. Western blot and immunofluorescence staining showed that BRD4 expression increased after administration of complete Freund’s adjuvant (CFA) and reached its peak on day 3. Immunofluorescence staining showed that BRD4 was mainly colocalized with NeuN-positive neurons in the spinal cord, which was accompanied by upregulation of inflammasome component proteins, such as NLRP3, gasdermin D, and caspase-1. JQ1 was intrathecally injected into mice 1 h before CFA administration, and the mechanical and thermal hyperalgesia levels were measured on days 1, 3, and 7 after CFA administration. CFA-induced inflammatory pain, paw inflammation, and swelling were attenuated by pre-treatment with JQ1. To our knowledge, this study was the first to prove that NLRP3 inflammasome-induced neuronal pyroptosis participates in inflammatory pain. BRD4 inhibition decreased the expression of pyroptosis-related proteins by inhibiting the activation of NF-κB signaling pathway, both in vivo and in vitro. Taken together, BRD4 inhibition exerted analgesic and anti-inflammatory effects against inflammatory pain by inhibiting NF-κB and inflammasome activation, which protected neural cells from pyroptosis.
Green–Light–Driven Poly(N-isopropylacrylamide-acrylamide)/Fe3O4 Nanocomposite Hydrogel Actuators
Authors: Cao Ying , Li Wenjiao , Quan Fengyu , Xia Yanzhi , Xiong Zhong 
Published: January 2022

Light-responsive hydrogel actuators show attractive biomedical applications for in vivo drug delivery tool, surgical tissue repair operation, and vascular cleaning due to its non-contact, rapid, precise, and remote spatial control of light. Conventional visible–light–responsive hydrogels contain special chemical structure or groups, and the difficulty in synthesis results in that few can be applied to fabricate visible–light–driven hydrogel actuators. In this study, based on photothermal effect, surface-modified Fe3O4 nanoparticles were incorporated into poly(N-isopropylacrylamide-acrylamide) hydrogel by UV photopolymerization, which revealed excellent green–light–responsive volume change. Under a laser irradiation of 200 mW at 520 nm, the bending angle deformation of hydrogel strips with 2.62 wt% Fe3O4 reached 107.8°. Strip-shaped hydrogel actuators could be applied to transport tiny objects. Furthermore, a boomerang-like hydrogel actuator was designed and fabricated to drive floating foam on water. By 12 cycles of continuous laser on–off irradiation to a hydrogel actuator underwater, a circular returning movement of the float was accomplished. The study on driving a float using visible–light–triggered hydrogel actuators provides a new idea for the design of light-driven biomedical devices and soft robots.
Clinical Application of Noninvasive Prenatal Testing for Sex Chromosome Aneuploidies in Central China
Authors: Zhao Ganye , Dai Peng , Wang Conghui , Liu Lina , Zhao Xuechao , Kong Xiangdong 
Published: January 2022

BackgroundThe relatively high incidence and the clinical symptoms of sex chromosome aneuploidies (SCAs) make prenatal screening of SCAs an attractive option for pregnant women. However, limited studies have assessed the clinical performance of noninvasive prenatal testing (NIPT) for screening SCAs. This study was performed to evaluate the clinical performance of NIPT for SCAs in singleton pregnancies in central China.MethodsNoninvasive prenatal testing was performed using next-generation sequencing. Standard Z-score analysis was used to identify fetal SCAs. NIPT-positive results were confirmed by invasive prenatal diagnosis (IPD).ResultsA total of 42,164 pregnant women with singleton pregnancies were recruited in this study. They were divided into the following five groups with different clinical indications: with ultrasound soft index abnormalities (9.23%, 3,892/42,164); with advanced maternal age (22.14%, 9,336/42,164); with high risk for maternal serum screening (MSS) (18.35%, 7,738/42,164); with an intermediate risk for MSS (26.6%, 11,215/42,164); and with low risk (23.68%, 9,983/42,164). In all, 223 women had a high risk for SCAs by NIPT with a positive rate of 0.53%. There was no significant difference associated with the five groups in the positive rate. Of all of the positive results, 89 were 45,X (39.91%), 38 were 47,XXX (17.04%), 31 were 46,XY,del(X) (13.90%), 50 were 47,XXY (22.42%,), and 15 were 47,XYY (6.73%). Finally, 147 participants (65.92%) chose to undergo IPD, and 47 cases were confirmed. The combined positive predictive value (PPV) of NIPT for SCA was 31.97% (47/147). PPV was high for 47,XYY (100%, 11/11), moderate for 47,XXX (42.86%, 9/21) and 47,XXY (45.45%, 15/33), but low for 45,X (16.13%, 10/62) and 46,XY,del(X) (10%, 2/20). The termination rates of Turner syndrome and 47,XXY syndrome were higher than 47,XXX and 47,XYY syndromes.ConclusionIn this relatively large cohort, we evaluated the value of NIPT for SCAs. Our data showed that with informed consent and subsequent professional genetical consulting, NIPT can be a useful method to screen SCAs.
Diagnostic Performance of Deep Learning Classifiers in Measuring Peripheral Anterior Synechia Based on Swept Source Optical Coherence Tomography Images
Authors: Yang Yangfan , Wu Yanyan , Guo Chong , Han Ying , Deng Mingjie , Lin Haotian , Yu Minbin 
Published: January 2022

PurposeTo develop deep learning classifiers and evaluate their diagnostic performance in detecting the static gonioscopic angle closure and peripheral anterior synechia (PAS) based on swept source optical coherence tomography (SS-OCT) images.Materials and MethodsSubjects were recruited from the Glaucoma Service at Zhongshan Ophthalmic Center of Sun Yat-sun University, Guangzhou, China. Each subject underwent a complete ocular examination, such as gonioscopy and SS-OCT imaging. Two deep learning classifiers, using convolutional neural networks (CNNs), were developed to diagnose the static gonioscopic angle closure and to differentiate appositional from synechial angle closure based on SS-OCT images. Area under the receiver operating characteristic (ROC) curve (AUC) was used as outcome measure to evaluate the diagnostic performance of two deep learning systems.ResultsA total of 439 eyes of 278 Chinese patients, which contained 175 eyes of positive PAS, were recruited to develop diagnostic models. For the diagnosis of static gonioscopic angle closure, the first deep learning classifier achieved an AUC of 0.963 (95% CI, 0.954–0.972) with a sensitivity of 0.929 and a specificity of 0.877. The AUC of the second deep learning classifier distinguishing appositional from synechial angle closure was 0.873 (95% CI, 0.864–0.882) with a sensitivity of 0.846 and a specificity of 0.764.ConclusionDeep learning systems based on SS-OCT images showed good diagnostic performance for gonioscopic angle closure and moderate performance in the detection of PAS.
Endotyping Seasonal Allergic Rhinitis in Children: A Cluster Analysis
Authors: Malizia Velia , Ferrante Giuliana , Cilluffo Giovanna , Gagliardo Rosalia , Landi Massimo , Montalbano Laura , Fasola Salvatore , Profita Mirella , Licari Amelia , Marseglia Gian Luigi , La Grutta Stefania 
Published: January 2022

BackgroundSeasonal Allergic Rhinitis (SAR) is a heterogeneous inflammatory disease. We hypothesized that a cluster analysis based on the evaluation of cytokines in nasal lavage (NL) could characterize distinctive SAR endotypes in children.MethodsThis cross-sectional study enrolled 88 children with SAR. Detailed medical history was obtained by well-trained physicians. Quality of life and sleep quality were assessed through standardized questionnaires [Pediatric Rhinoconjunctivitis Quality of Life Questionnaire (PRQLQ) and Pittsburgh Sleep Quality Index (PSQI) respectively]. Children were grouped through K-means clustering using Interleukin (IL)-5, IL-17, IL-23, and Interferon (INF)-γ in NL.ResultsOut of the 88 patients enrolled, 80 were included in the cluster analysis, which revealed three SAR endotypes. Cluster 1 showed lower levels of IL-5 and IL-17 and intermediate levels of IL-23 and IFN-γ; Cluster 2 had higher levels of IL-5 and intermediate levels of IL-17, IL-23, and IFN-γ; Cluster 3 showed higher levels of IL-17, IL-23, and IFN-γ and intermediate levels of IL-5. Cluster 1 showed intermediate values of nasal pH and nasal nitric oxide (nNO), and a lower percentage of neutrophils at nasal cytology than Clusters 2 and 3. Cluster 2 had a lower level of nasal pH, a higher nNO, higher scores in the ocular domain of PRQLQ, and worse sleep quality than Clusters 1 and 3. Cluster 3 showed a higher percentage of neutrophils at nasal cytology than Clusters 1 and 2.ConclusionsOur study identified three endotypes based on the evaluation of cytokines in NL, highlighting that childhood SAR is characterized by heterogeneous inflammatory cytokines.
Residual Renal Function – How Fast Does the Residual Urine Output Function Decline in the First Year of Haemodialysis? – A Scoping Review
Authors: Steinwandel Ulrich , Kheirkhah Homa , Davies Hugh 
Published: January 2022

BackgroundHaemodialysis is the most common treatment method in Australia for individuals requiring renal replacement therapy. Although it is known that the residual renal function in these patients has many advantages for their overall health outcomes and that the residual urine volume production is also declining over time, it is unknown how fast this functional decline occurs when patients are embarking on their first year on haemodialysis.AimThis scoping review sought to determine if the functional decline in renal residual function in the first year of haemodialysis has been previously investigated, documented or quantified.MethodThe scoping review was performed using variety of nursing and medical databases comprising MEDLINE, Embase, Web of Science and CINAHL Plus with Full Text.ResultsThe decline of renal residual function in patients on Peritoneal dialysis over the first year of treatment has previously been described, but not in detail for patients receiving haemodialysis. There is a paucity of knowledge how fast residual urine production can decline in patients receiving haemodialysis during their first year of treatment. A PRISMA checklist has been used to validate the results of this scoping review.ConclusionsThe extended preservation of renal residual function in patients on haemodialysis is crucial for their survival and may have a positive impact on their quality of life. An observational study is needed to examine how fast the functional decrease of the residual urine production function within patients receiving haemodialysis generally occurs. This information could prove to be useful in the context of treatment goals and could inform clinical practice.