bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyzing non-technical skills in the sharp end of facilities/utilities operations in onshore and offshore O&G process plants
Authors: França Josué , Oliveira Antônio , Silva Luciana , Karlsson Pär 
Published: November 2022

AbstractIt is on the sharp end of the O&G operations where the real work happens, but also where the highest risks and system demands are placed. Understanding the skills—technical and non-technical—necessary to perform efficiently and safely is not only needed to maintain the business and assets, but also to ensure the safety of lives and the environment. Accidents such as Piper Alpha (1988), P-36 (2001) and Deepwater Horizon (2010) highlight the importance of understanding the real role of the human element in these events, from the highest hierarchical levels to the sharp end, where the work as done takes place. This article presents a non-technical skills analysis focused on the sharp end of O&G operations, specifically in the facilities/utilities operations, onshore (refineries) and offshore (production platforms). The findings show the importance and presence of certain non-technical skills, as well as the need for improvement of others in the daily routine and in emergencies.
Pathogenic Interleukin-10 Receptor Alpha Variants in Humans — Balancing Natural Selection and Clinical Implications
Authors: Aschenbrenner Dominik , Ye Ziqing , Zhou Ying , Hu Wenhui , Brooks Isabel , Williams Isabelle , Capitani Melania , Gartner Lisa , Kotlarz Daniel , Snapper Scott B. , Klein Christoph , Muise Aleixo M. , Marsden Brian D. , Huang Ying , Uhlig Holm H. 
Published: November 2022

AbstractBalancing natural selection is a process by which genetic variants arise in populations that are beneficial to heterozygous carriers, but pathogenic when homozygous. We systematically investigated the prevalence, structural, and functional consequences of pathogenic IL10RA variants that are associated with monogenic inflammatory bowel disease. We identify 36 non-synonymous and non-sense variants in the IL10RA gene. Since the majority of these IL10RA variants have not been functionally characterized, we performed a systematic screening of their impact on STAT3 phosphorylation upon IL-10 stimulation. Based on the geographic accumulation of confirmed pathogenic IL10RA variants in East Asia and in Northeast China, the distribution of infectious disorders worldwide, and the functional evidence of IL-10 signaling in the pathogenesis, we identify Schistosoma japonicum infection as plausible selection pressure driving variation in IL10RA. Consistent with this is a partially augmented IL-10 response in peripheral blood mononuclear cells from heterozygous variant carriers. A parasite-driven heterozygote advantage through reduced IL-10 signaling has implications for health care utilization in regions with high allele frequencies and potentially indicates pathogen eradication strategies that target IL-10 signaling.
Graphical abstract
Examining the Prospective Bidirectional Associations between Subjective and Objective Attractiveness and Adolescent Internalizing Symptoms and Life Satisfaction
Authors: Magson Natasha R. , Oar Ella L. , Fardouly Jasmine , Rapee Ronald M. , Freeman Justin Y. A. , Richardson Cele E. , Johnco Carly J. 
Published: November 2022

AbstractResearch has consistently shown that more physically attractive individuals are perceived by others to be happier and better psychologically adjusted than those perceived as less attractive. However, due to the lack of longitudinal research in adolescents, it is still unclear whether poor mental health predicts or is predicted by either objective or subjective attractiveness during this critical developmental period. The purpose of the current study was to examine prospective bidirectional associations between both subjective and objective ratings of attractiveness, life satisfaction and symptoms of social anxiety, depression and eating disorders (i.e., internalizing symptoms) from early to mid-adolescence. Participants (T1: N = 528, 49.9% girls; Mage = 11.19; SD = 0.55) were followed annually over four time points. The cross-lagged panel model results revealed evidence of prospective associations between both forms of attractiveness and life satisfaction and internalizing symptoms, which were driven more by changes in the mental health outcomes than by changes in the subjective and objective attractiveness ratings. The results also indicated that the pattern, strength, and direction of the associations tested were robust across boys and girls, and white and non-white ethnic groups. Overall, the findings suggest that it is important to find effective ways of educating adolescents who are unhappy with their appearance that making changes to improve their mental health, rather than focusing on their physical appearance, will have benefits not only for how they perceive themselves but also for how they are perceived by others.
The downstream PPARγ target LRRC1 participates in early stage adipocytic differentiation
Authors: Wang Xinping , Liu Jianyun , Wang Ting , Ma Baicheng , Wu Ping , Xu Xiaoyuan , Xiong Jianjun 
Published: November 2022

AbstractLRRC1 is a regulator of cellular polarity that is expressed at high levels in a range of tumor tissue types. Here, we conducted an analysis of the previously unexplored role of LRRC1 as a component of the adipogenic differentiation network. During the early stage (days 3–7) adipocytic differentiation of human mesenchymal stem cells (MSCs), LRRC1 was found to be upregulated at both the mRNA and protein levels. Moreover, the expression of LRRC1 was found to be controlled by PPARγ, which is a key transcriptional regulator of adipogenesis. Inhibiting LRRC1 expression reduced the adipogenic potential of hMSCs, with a concomitant reduction in the expression of three adipogenesis-associated proteins (SCD, LIPE, FASN). Together, these data offer new insight into the functional importance of LRRC1 both in general and in the context of adipocytic differentiation.
The prognostic role of C-KIT, TET1 and TET2 gene expression in Acute Myeloid Leukemia
Authors: Nabil Reem , Hassan Naglaa M. , Abdellateif Mona S. , Gawdat Rania M. , Elshazly Samar Sami 
Published: November 2022

Abstract
Aim
was to assess the role of C-KIT, TET1 and TET2 expression in the diagnosis and prognosis of acute myeloblastic leukemia (AML).

Methods
The expression levels of C-KIT, TET1 and TET2 were assessed in the bone marrow (BM) aspirate of 152 AML patients compared to 20 healthy control using quantitative real-time polymerase chain reaction (qRT-PCR). Data were correlated with the clinico-pathological features of the patients, response to treatment, disease-free survival (DFS), and overall survival (OS) rates.

Results
C-KIT, TET1 and TET2 were significantly upregulated in AML patients [0.25 (0–11.6), 0.0113 (0–3.301), and 0.07 (0–4); respectively], compared to the control group [0.013 (0.005–0.250), P < 0.001, 0.001 (0–0.006), P < 0.001, and 0.02 (0.008–0.055), P = 0.019; respectively]. The sensitivity, specificity, and area under curve of of C-KIT were (48.7%, 100%, 0.855; respectively, P = 0.001), and that of TET1 were (63.4%, 100%, 0.897; respectively, P = 0.001), while that of TET2 were (56.8%, 100%, 0.766; respectively, P = 0.019). When combining the three markers, the sensitivity was 77.5%, however it reached the highest sensitivity (78.6%) and specificity (100%) when combining both c-KIT + TET1 together for the diagnosis of AML. C-KIT overexpression associated with shorter DFS (P = 0.05) and increased incidence of relapse (P = 0.019). Lymph nodes involvement [HR = 2.200, P = 0.005] is an independent risk factor for shorter OS rate of AML patients. Increased BM blast % [HR = 7.768, P = 0.002], and FLT3-ITD mutation [HR = 2.989, P = 0.032] are independent risk factors for shorter DSF rate of the patients.

Conclusion
C-KIT, TET1, and TET2 could be used as possible useful biomarkers for the diagnosis of AML.
Propagation characteristics of an elastic bar coupled with a discrete snap-through element
Authors: Bhattacharyya Aneesh , Adhikari Sondipon 
Published: November 2022

AbstractWave propagation characteristics of an elastic bar coupled at one end with a single degree of freedom, bi-stable, essentially nonlinear snap-through element are considered. The free end of the bar is subjected to sinusoidal excitations. A novel approach based on multiple time scales and harmonic balance method has been proposed to analytically investigate the reflected wave from the nonlinear interface and the dynamic response of the snap-through element. A unified approach to the non-dimensional representation of the governing equations of motion, boundary conditions and system parameters, which is consistent across all the externally applied excitation frequencies and excitation amplitudes, has been developed. Through Taylor series expansion of the non-autonomous forcing functions arising in the governing differential equations and natural boundary condition about an initial stable configuration of the system and the proposed asymptotic method, approximate closed-form analytical solutions have been derived for sufficiently small amplitudes of the excitation pulse. Numerical results obtained through a finite difference algorithm validate the asymptotic model for the same small amplitudes of the excitation pulse. A stability analysis has been subsequently performed for the discrete snap-through element by using the extended Floquet theory for sufficiently large amplitudes of the excitation pulse by approximating the displacement at the nonlinear interface as a sinusoidal function of time, and the Mathieu plot of the excitation frequency vs the excitation amplitude showing the stable and unstable regions for the motion of the snap-through element has been generated. The expressions derived here give the most comprehensive and consistent description of the wave propagation characteristics and the motion of the snap-through element, which can be directly used in finite difference analysis over a wide range of parameter values of the excitation pulse.
Development of a multi-technology, template-based quantum circuits compilation toolchain
Authors: Avitabile Manfredi , Cirillo Giovanni Amedeo , Simoni Mario , Turvani Giovanna , Graziano Mariagrazia 
Published: November 2022

AbstractWith noisy intermediate scale quantum computers (NISQ) becoming larger in scale and more reliable, quantum circuits are growing in size and complexity. In order to face the challenge of achieving optimal circuits, design automation approaches for improving and mapping quantum circuits on different architectures have been proposed, each one characterized by a specific optimization strategy. In this article, the use of a template-based approach for quantum circuits optimization purposes is explored, and the proposal of a modular compilation toolchain, which supports three quantum technologies (nuclear magnetic resonance, trapped ions and superconducting qubits), is presented. The toolchain tackles the task of implementing logic synthesis for single-qubit and multi-qubit gates in the compilation process and it is structured with multiple steps and modular libraries. The toolchain was tested through a benchmarking procedure, and the results for a subset of complex quantum circuits as inputs are here reported, alongside a comparison with those provided by the compilers of IBM’s Qiskit and Cambridge Quantum Computing’s$$ \mathrm{\left. {t|ket} \right\rangle } $$t|ket. The current toolchain prototype was crafted to be an easily expandable and reliable core for future developments, which could lead it to support even more quantum technologies and a fully fledged layout synthesis. Nonetheless, the obtained results are quite encouraging, and they prove that in certain conditions the Toolchain can be competitive in quantum circuits optimization, especially when dealing with single-qubit gates.
In Vitro Bioactivities of Food Grade Extracts from Yarrow (Achillea millefolium L.) and Stinging Nettle (Urtica dioica L.) Leaves
Authors: Mannila Enni , Marti-Quijal Francisco J. , Selma-Royo Marta , Calatayud Marta , Falcó Irene , de la Fuente Beatriz , Barba Francisco J. , Collado Maria Carmen , Linderborg Kaisa M. 
Published: November 2022

Abstract
Yarrow (Achillea millefolium L., AM) and nettle (Urtica dioica L., UD) are bioactive plants used commercially in functional food and supplement applications and traditionally to alleviate gastric disorders. In this work, the effects of food-grade optimized extracts of Finnish early-season AM and UD were tested on bacterial growth including potential beneficial and foodborne pathogens, as well as murine norovirus (MNV). The anti-inflammatory properties of the extracts were also tested in vitro by NF-κB reporter cells. The food-grade extraction was optimized with the response surface modelling in terms of total carotenoid, chlorophyll, and phenolic compounds contents and antioxidant capacities. The optimal food-grade extraction parameters were a 1-h extraction in 70% ethanol at 45 °C for AM, and at 49 °C for UD. There were no significant effects on the beneficial bacteria (Lacticaseibacillus and Bifidobacterium strains), and the extracts were more effective against gram-positive than gram-negative foodborne bacteria and potential pathogens. Listeria innocua was the most susceptible strain in the optimized extracts with a growth rate of 0.059 ± 0.004 for AM and 0.067 ± 0.006 for UD, p < 0.05 compared to control. The optimized extracts showed a logarithmic growth reduction of 0.67 compared to MNV. The hydroethanolic extracts were cytotoxic to both cell lines, whereas aqueous AM and UD extracts induced and reduced TLR4 signalling in a reporter cell line, respectively. The results provide novel food-grade extraction parameters and support the bioactive effects of AM and UD in functional food applications, but more research is needed to elucidate the precise biological activity in vivo for gastric health.
An in situ study of the thermal decomposition of 2,2′-azobis(2-methylpropionitrile) radical chemistry using a dual-mode EPR resonator
Authors: Magri Giuseppina , Barter Michael , Fletcher-Charles Jack , Choi Heungjae , Slocombe Daniel , Richards Emma , Folli Andrea , Porch Adrian , Murphy Damien M. 
Published: November 2022

AbstractA custom-built dual-mode EPR resonator was used to study the radical chemistry of AIBN thermal decomposition. This resonator enables both simultaneous in situ heating using microwaves and EPR measurements to be performed. The thermal decomposition of AIBN was compared following conventional heating methods and microwave-induced (or dielectric) heating methods. Under both heating conditions, the radicals formed and detected by EPR include the 2-cyano-2-propyl (CP●) and 2-cyano-2-propoxyl (CPO●) radicals. Under aerobic conditions, the observed relative distribution of these radicals as observed by EPR is similar following slow heating by conventional or dielectric methods. In both conditions, the kinetically favoured CPO● radicals and their adducts dominate the EPR spectra up to temperatures of approximately 80–90 °C. Under anaerobic conditions, the distribution can be altered as less CPO● is available. However, the observed results are notably different when rapid heating (primarily applied using a MW-induced T-jump) is applied. As the higher reaction temperatures are achieved on a faster timescale, none of the ST●-CPO adducts are actually visible in the EPR spectra. The more rapid and facile heating capabilities created by microwaves may therefore lead to the non-detection of radical intermediates compared to experiments performed using conventional heating methods.
Combining voltammetric and mass spectrometric data to evaluate iron organic speciation in subsurface coastal seawater samples of the Ross sea (Antarctica)
Authors: Vivado Davide , Ardini Francisco , Salis Annalisa , Damonte Gianluca , Rivaro Paola 
Published: November 2022

Abstract
Iron (Fe) is the most important trace element in the ocean, as it is required by phytoplankton for photosynthesis and nitrate assimilation. Iron speciation is important to better understand the biogeochemical cycle and availability of this micronutrient, in particular in the Southern Ocean. Dissolved Fe (dFe) concentration and speciation were determined in 24 coastal subsurface seawater samples collected in the western Ross sea (Antarctica) during the austral summer 2017 as part of the CELEBeR (CDW Effects on glacial mElting and on Bulk of Fe in the Western Ross sea) project. ICP-DRC-MS was used for dFe determination, whereas CLE-AdSV was used to obtain the concentration of complexed and free dFe, of the ligands, and the values of the stability constants of the complexes. Dissolved Fe values ranged from 0.4 to 2.5 nM and conditional stability constant (logK’Fe’L) from 13.0 to 15.0, highlighting the presence of Fe-binding organic complexes of different stabilities. Principal component analysis (PCA) allowed us to point out that Terra Nova Bay and the neighboring area of Aviator and Mariner Glaciers were different in terms of chemical, physical, and biological parameters. A qualitative investigation on the nature of the organic ligands was carried out by HPLC–ESI–MS/MS. Results showed that siderophores represented a heterogeneous class of organic ligands pool.
A high-fidelity prototype of a sterile information system for the perioperative area: OR-Pad
Authors: Ryniak C. , Frommer S. M. , Junger D. , Lohmann S. , Stadelmaier M. , Schmutz P. , Stenzl A. , Hirt B. , Burgert O. 
Published: November 2022

Abstract
Purpose
Supporting the surgeon during surgery is one of the main goals of intelligent ORs. The OR-Pad project aims to optimize the information flow within the perioperative area. A shared information space should enable appropriate preparation and provision of relevant information at any time before, during, and after surgery.

Methods
Based on previous work on an interaction concept and system architecture for the sterile OR-Pad system, we designed a user interface for mobile and intraoperative (stationary) use, focusing on the most important functionalities like clear information provision to reduce information overload. The concepts were transferred into a high-fidelity prototype for demonstration purposes. The prototype was evaluated from different perspectives, including a usability study.

Results
The prototype’s central element is a timeline displaying all available case information chronologically, like radiological images, labor findings, or notes. This information space can be adapted for individual purposes (e.g., highlighting a tumor, filtering for own material). With the mobile and intraoperative mode of the system, relevant information can be added, preselected, viewed, and extended during the perioperative process. Overall, the evaluation showed good results and confirmed the vision of the information system.

Conclusion
The high-fidelity prototype of the information system OR-Pad focuses on supporting the surgeon via a timeline making all available case information accessible before, during, and after surgery. The information space can be personalized to enable targeted support. Further development is reasonable to optimize the approach and address missing or insufficient aspects, like the holding arm and sterility concept or new desired features.
Single and combined effects of fertilization, ectomycorrhizal inoculation, and drought on container-grown Japanese larch seedlings
Authors: Agathokleous Evgenios , Kitao Mitsutoshi , Komatsu Masabumi , Tamai Yutaka , Harayama Hisanori , Koike Takayoshi 
Published: November 2022

AbstractClimate change can intensify drought in many regions of the world and lead to more frequent drought events or altered cycles of soil water status. Therefore, it is important to enhance the tolerance to drought and thus health, vigor, and success of transplantation seedlings used in the forestry by modifying fertilization and promoting mycorrhization. Here, we sowed seeds of Japanese larch (Larix kaempferi) in 0.2-L containers with 0.5 g (low fertilization; LF) or 2 g (high fertilization; HF) of slow-release fertilizer early in the growing season. One month later, we irrigated seedlings with non-sterilized ectomycorrhizal inoculum (ECM) or sterilized solution (non-ECM), and after about 2 months, plants were either kept well watered (WW; 500 mL water/plant/week) or subjected to drought (DR; 50 mL water per plant/week) until the end of the growing season. HF largely stimulated plant growth and above- and belowground biomass production, effects that are of practical significance, but caused a small decrease in stomatal conductance (Gs390) and transpiration rate (E390), which in practice is insignificant. ECM treatment resulted in moderate inhibition of seedling growth and biomass and largely canceled out the enhancement of biomass and foliar K content by HF. DR caused a large decrease in CO2assimilation, and enhanced stomatal closure and induced senescence. DR also largely depleted foliar Mg and enriched foliar K. Although DR caused a large decrease in foliar P content in LF, it moderately increased P in HF. Likewise, DR increased foliar K in HF but not in LF, and decreased foliar P in ECM plants but not in non-ECM plants. Conversely, ECM plants exhibited a large enrichment in foliar P under WW and had a lower water potential under DR when grown in LF. These results indicate that the drought tolerance and health and vigor of Japanese larch seedlings can be modified by soil fertility and soil microorganisms. This study provides a basis for new multifactorial research programs aimed at producing seedlings of superior quality for forestation under climate change.
Urinary Leukotriene E4 as a Biomarker in NSAID-Exacerbated Respiratory Disease (N-ERD): a Systematic Review and Meta-analysis
Authors: Marquette Malcolm , Tailor Bhavesh V. , Calder Philip C. , Curtis Peter J. , Loke Yoon , Wilson Andrew M. 
Published: November 2022

Abstract
Purpose of Review
Non-steroidal exacerbated respiratory disease (N-ERD) currently requires aspirin challenge testing for diagnosis. Urinary leukotriene E4 (uLTE4) has been extensively investigated as potential biomarker in N-ERD. We aimed to assess the usefulness of uLTE4 as a biomarker in the diagnosis of N-ERD.

Recent Findings
N-ERD, formerly known as aspirin-intolerant asthma (AIA), is characterised by increased leukotriene production. uLTE4 indicates cysteinyl leukotriene production, and a potential biomarker in N-ERD. Although several studies and have examined the relationship between uLTE4 and N-ERD, the usefulness of uLTE4 as a biomarker in a clinical setting remains unclear.

Findings
Our literature search identified 38 unique eligible studies, 35 were included in the meta-analysis. Meta-analysis was performed (i.e. pooled standardised mean difference (SMD) with 95% confidence intervals (95% CI)) and risk of bias assessed (implementing Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy (Cochrane DTA)). Data from 3376 subjects was analysed (1354 N-ERD, 1420 ATA, and 602 HC). uLTE4 was higher in N-ERD vs ATA (n = 35, SMD 0.80; 95% CI 0.72–0.89). uLTE4 increased following aspirin challenge in N-ERD (n = 12, SMD 0.56; 95% CI 0.26–0.85) but not ATA (n = 8, SMD 0.12; CI − 0.08–0.33). This systematic review and meta-analysis showed that uLTE4 is higher in N-ERD than ATA or HC. Likewise, people with N-ERD have greater increases in uLTE4 following aspirin challenge. However, due to the varied uLTE4 measurement and result reporting practice, clinical utility of these findings is limited. Future studies should be standardised to increase clinical significance and interpretability of the results.