bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of preeclampsia on adverse maternal outcomes in Sidama region, Ethiopia: a prospective open cohort study
Authors: Jikamo Birhanu , Adefris Mulat , Azale Telake , Alemu Kassahun 
Published: November 2022

AbstractEthiopia has made improvements in the reduction of maternal mortality; the high burden of preeclampsia remains a concern in the Sidama region. This study aimed to measure the effect of preeclampsia on adverse maternal outcomes and identify risk factors among women with preeclampsia in Sidama region. A prospective open cohort study was conducted from August 8, 2019, to October 1, 2020. We enrolled a total of 1015 the pregnant women who had preeclampsia and normotensive women at ≥ 20 weeks of gestation and followed them until 42 days after delivery. A log-binomial logistic regression model was used to estimate the incidence of adverse maternal outcomes and its risk factors. There were 276 adverse maternal outcomes observed in the preeclampsia group compared to 154 adverse maternal outcomes in the normotensive group (P < 0.001). Women with severe features of preeclampsia had a 43% (aRR = 1.43, 95% CI 1.3–1.58) higher risk for adverse maternal outcomes compared to women without severe features of preeclampsia. Women without severe features of preeclampsia had a 39% (aRR = 1.39, 95% CI 1.2–1.76) higher risk for adverse maternal outcomes compared to women in the normotensive group. More adverse maternal outcomes occurred among women with preeclampsia after controlling for confounders.
Impacts of meeting minimum access on critical earth systems amidst the Great Inequality
Authors: Rammelt Crelis F. , Gupta Joyeeta , Liverman Diana , Scholtens Joeri , Ciobanu Daniel , Abrams Jesse F. , Bai Xuemei , Gifford Lauren , Gordon Christopher , Hurlbert Margot , Inoue Cristina Y. A. , Jacobson Lisa , Lade Steven J. , Lenton Timothy M. , McKay David I. Armstrong , Nakicenovic Nebojsa , Okereke Chukwumerije , Otto Ilona M. , Pereira Laura M. , Prodani Klaudia , Rockström Johan , Stewart-Koster Ben , Verburg Peter H. , Zimm Caroline 
Published: November 2022

AbstractThe Sustainable Development Goals aim to improve access to resources and services, reduce environmental degradation, eradicate poverty and reduce inequality. However, the magnitude of the environmental burden that would arise from meeting the needs of the poorest is under debate—especially when compared to much larger burdens from the rich. We show that the ‘Great Acceleration’ of human impacts was characterized by a ‘Great Inequality’ in using and damaging the environment. We then operationalize ‘just access’ to minimum energy, water, food and infrastructure. We show that achieving just access in 2018, with existing inequalities, technologies and behaviours, would have produced 2–26% additional impacts on the Earth’s natural systems of climate, water, land and nutrients—thus further crossing planetary boundaries. These hypothetical impacts, caused by about a third of humanity, equalled those caused by the wealthiest 1–4%. Technological and behavioural changes thus far, while important, did not deliver just access within a stable Earth system. Achieving these goals therefore calls for a radical redistribution of resources.
NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance
Authors: Hodgson Rose , Xu Xijin , Anzilotti Consuelo , Deobagkar-Lele Mukta , Crockford Tanya L. , Kepple Jessica D. , Cawthorne Eleanor , Bhandari Aneesha , Cebrian-Serrano Alberto , Wilcock Martin J. , Davies Benjamin , Cornall Richard J. , Bull Katherine R. 
Published: November 2022

AbstractPeripheral tolerance prevents the initiation of damaging immune responses by autoreactive lymphocytes. While tolerogenic mechanisms are tightly regulated by antigen-dependent and independent signals, downstream pathways are incompletely understood. N-myc downstream-regulated gene 1 (NDRG1), an anti-cancer therapeutic target, has previously been implicated as a CD4+T cell clonal anergy factor. By RNA-sequencing, we identifiedNdrg1as the third most upregulated gene in anergic, compared to naïve follicular, B cells.Ndrg1is upregulated by B cell receptor activation (signal one) and suppressed by co-stimulation (signal two), suggesting that NDRG1 may be important in B cell tolerance. However, thoughNdrg1−/−mice have a neurological defect mimicking NDRG1-associated Charcot-Marie-Tooth (CMT4d) disease, primary and secondary immune responses were normal. We find that B cell tolerance is maintained, and NDRG1 does not play a role in downstream responses during re-stimulation of in vivo antigen-experienced CD4+T cells, demonstrating that NDGR1 is functionally redundant for lymphocyte anergy.
Stacked distribution models predict climate-driven loss of variation in leaf phenology at continental scales
Authors: Bayliss Shannon L. J. , Mueller Liam O. , Ware Ian M. , Schweitzer Jennifer A. , Bailey Joseph K. 
Published: November 2022

AbstractClimate change is having profound effects on species distributions and is likely altering the distribution of genetic variation across landscapes. Maintaining population genetic diversity is essential for the survival of species facing rapid environmental change, and variation loss will further ecological and evolutionary change. We used trait values of spring foliar leaf-out phenology of 400 genotypes from three geographically isolated populations of Populus angustifolia grown under common conditions, in concert with stacked species distribution modeling, to ask: (a) How will climate change alter phenological variation across the P. angustifolia species-range, and within populations; and (b) will the distribution of phenological variation among and within populations converge (become more similar) in future climatic conditions? Models predicted a net loss of phenological variation in future climate scenarios on 20-25% of the landscape across the species’ range, with the trailing edge population losing variation on as much as 47% of the landscape. Our models also predicted that population’s phenological trait distributions will become more similar over time. This stacked distribution model approach allows for the identification of areas expected to experience the greatest loss of genetically based functional trait variation and areas that may be priorities to conserve as future genetic climate refugia.
R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations
Authors: Xenias Harry S. , Chen Chuyu , Kang Shuo , Cherian Suraj , Situ Xiaolei , Shanmugasundaram Bharanidharan , Liu Guoxiang , Scesa Giuseppe , Chan C. Savio , Parisiadou Loukia 
Published: November 2022

AbstractLRRK2 mutations are closely associated with Parkinson’s disease (PD). Convergent evidence suggests that LRRK2 regulates striatal function. Here, by using knock-in mouse lines expressing the two most common LRRK2 pathogenic mutations—G2019S and R1441C—we investigated how LRRK2 mutations altered striatal physiology. While we found that both R1441C and G2019S mice displayed reduced nigrostriatal dopamine release, hypoexcitability in indirect-pathway striatal projection neurons, and alterations associated with an impaired striatal-dependent motor learning were observed only in the R1441C mice. We also showed that increased synaptic PKA activities in the R1441C and not G2019S mice underlie the specific alterations in motor learning deficits in the R1441C mice. In summary, our data argue that LRRK2 mutations’ impact on the striatum cannot be simply generalized. Instead, alterations in electrochemical, electrophysiological, molecular, and behavioral levels were distinct between LRRK2 mutations. Our findings offer mechanistic insights for devising and optimizing treatment strategies for PD patients.
Immune and spermatogenesis-related loci are involved in the development of extreme patterns of male infertility
Authors: Cerván-Martín Miriam , Tüttelmann Frank , Lopes Alexandra M. , Bossini-Castillo Lara , Rivera-Egea Rocío , Garrido Nicolás , Lujan Saturnino , Romeu Gema , Santos-Ribeiro Samuel , Castilla José A. , Carmen Gonzalvo M. , Clavero Ana , Maldonado Vicente , Vicente F. Javier , González-Muñoz Sara , Guzmán-Jiménez Andrea , Burgos Miguel , Jiménez Rafael , Pacheco Alberto , González Cristina , Gómez Susana , Amorós David , Aguilar Jesus , Quintana Fernando , Calhaz-Jorge Carlos , Aguiar Ana , Nunes Joaquim , Sousa Sandra , Pereira Isabel , Pinto Maria Graça , Correia Sónia , Sánchez-Curbelo Josvany , López-Rodrigo Olga , Martín Javier , Pereira-Caetano Iris , Marques Patricia I. , Carvalho Filipa , Barros Alberto , Gromoll Jörg , Bassas Lluís , Seixas Susana , Gonçalves João , Larriba Sara , Kliesch Sabine , Palomino-Morales Rogelio J. , Carmona F. David 
Published: November 2022

AbstractWe conducted a genome-wide association study in a large population of infertile men due to unexplained spermatogenic failure (SPGF). More than seven million genetic variants were analysed in 1,274 SPGF cases and 1,951 unaffected controls from two independent European cohorts. Two genomic regions were associated with the most severe histological pattern of SPGF, defined by Sertoli cell-only (SCO) phenotype, namely the MHC class II gene HLA-DRB1 (rs1136759, P = 1.32E-08, OR = 1.80) and an upstream locus of VRK1 (rs115054029, P = 4.24E-08, OR = 3.14), which encodes a protein kinase involved in the regulation of spermatogenesis. The SCO-associated rs1136759 allele (G) determines a serine in the position 13 of the HLA-DRβ1 molecule located in the antigen-binding pocket. Overall, our data support the notion of unexplained SPGF as a complex trait influenced by common variation in the genome, with the SCO phenotype likely representing an immune-mediated condition.
Bayesian optimization-driven parallel-screening of multiple parameters for the flow synthesis of biaryl compounds
Authors: Kondo Masaru , Wathsala H. D. P. , Salem Mohamed S. H. , Ishikawa Kazunori , Hara Satoshi , Takaai Takayuki , Washio Takashi , Sasai Hiroaki , Takizawa Shinobu 
Published: November 2022

AbstractTraditional optimization methods using one variable at a time approach waste time and chemicals and assume that different parameters are independent from one another. Hence, a simpler, more practical, and rapid process for predicting reaction conditions that can be applied to several manufacturing environmentally sustainable processes is highly desirable. In this study, biaryl compounds were synthesized efficiently using an organic Brønsted acid catalyst in a flow system. Bayesian optimization-assisted multi-parameter screening, which employs one-hot encoding and appropriate acquisition function, rapidly predicted the suitable conditions for the synthesis of 2-amino-2′-hydroxy-biaryls (maximum yield of 96%). The established protocol was also applied in an optimization process for the efficient synthesis of 2,2′-dihydroxy biaryls (up to 97% yield). The optimized reaction conditions were successfully applied to gram-scale synthesis. We believe our algorithm can be beneficial as it can screen a reactor design without complicated quantification and descriptors.
Double boron-embedded multiresonant thermally activated delayed fluorescent materials for organic light-emitting diodes
Authors: Naveen Kenkera Rayappa , Yang Hye In , Kwon Jang Hyuk 
Published: November 2022

AbstractThe subclass of multi resonant thermally activated delayed fluorescent emitters (MR-TADF) containing boron atoms has garnered significant attention in the field of organic light emitting diode (OLED) research. Among boron-basedMR-TADFemitters, double boron-embeddedMR-TADF(DB-MR-TADF) emitters show excellent electroluminescence performances with high photoluminescence quantum yields, narrow band emission, and beneficially small singlet-triplet energy levels in all the full-color gamut regions. This article reviews recent progress inDB-MR-TADFemitters, with particular attention to molecular design concepts, synthetic routes, optoelectronic properties, and OLED performance, giving future prospects for real-world applications.
Humidification of Central Asia and equatorward shifts of westerly winds since the late Pliocene
Authors: Zhong Yi , Shi Xuefa , Yang Hu , Wilson David J. , Hein James R. , Kaboth-Bahr Stefanie , Lu Zhengyao , Clift Peter D. , Yan Qing , Lohmann Gerrit , Liu Jiabo , González Francisco Javier , Jiang Xiaodong , Jiang Zhaoxia , Liu Qingsong 
Published: November 2022

AbstractThe production, transport, and deposition of mineral dust exert major influences on climate change and Earth’s biogeochemical cycles. Furthermore, their imprint, as recorded in pelagic sediments, provides an avenue for determining past changes in terrestrial aridity and atmospheric circulation patterns in response to global climate change. Here, by examining geochemical and magnetic data obtained from a ferromanganese crust in the western Pacific Ocean, we investigate the eolian dust source-region conditions and dust transport mechanisms from the Asian interior to the Pacific Ocean since the Pliocene. We identify a gradual provenance change in the dust source regions, from a dominant Gobi Desert source during the early Pliocene to a mixed Gobi-Taklimakan Desert source during the late Pliocene and Pleistocene, alongside increasing chemical weathering in those source areas. Climate model simulations suggest that these changes were related to an equatorward shift of the westerly jet and humidification of Central Asia during the gradual transition from a warm Pliocene climate to the cool Pleistocene.
Systematic Review of the Relation Between Feeding Problems and Sensory Processing in Children With Autism Spectrum Disorder
Authors: Elsayed Heba E. , Thompson Kelsey L. , Conklin Jamie L. , Watson Linda R. 
Published: November 2022

Purpose:
Many studies have linked sensory sensitivities to feeding problems in children with autism spectrum disorder (ASD). Despite the importance of sensory processing for a variety of mealtime and eating skills, the specific sensory processes that may impact feeding problems in children with ASD have not been comprehensively reviewed. Thus, the goal of this systematic review was to understand the associations between sensory processing and feeding difficulties in children with ASD.

Method:
This systematic review was carried out according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The PubMed, CINAHL Plus with Full Text (EBSCOhost), Scopus (Elsevier), and Embase (Elsevier) databases were searched from their dates of inception through the final search date of April 19, 2022, for English language studies that examined both sensory processing and feeding among children with ASD. Studies were assessed for quality using the Joanna Briggs Institute critical appraisal tools.

Results:
A total of 27 studies were included. Findings supported the existence of a relationship between sensory processing and feeding problems in children with ASD. Specifically, studies reported that overall scores on sensory processing measures as well as measures of oral sensory processing were frequently associated with feeding problems.

Conclusions:
This review supports the development of future feeding interventions focusing on sensory processing given the relationship between sensory processing and feeding problems among children with ASD. Future research should focus on utilizing consistent feeding assessments specific to children with ASD and collect information on medical diagnoses that can impact feeding in order to report on feeding more holistically in this population.

Supplemental Material:

https://doi.org/10.23641/asha.21453909
Measuring Aphasia-Related Quality of Life: Efficiency and Cost of Change
Authors: Jacobs Molly , Ellis Charles 
Published: November 2022

Purpose:
Changes in quality of life (QoL) in persons with aphasia (PWA) has emerged as a key metric of aphasia treatment effectiveness. Several tools have been designed to measure aphasia related QoL and offer the appropriate compensation for communication issues that frequently exclude persons with aphasia (PWA) from participation of such studies. The purpose of this study was to measure post–aphasia treatment change in QoL and calculate the efficiency and cost of QoL change.

Method:
In this study, we measured change in aphasia-related QoL as a metric of post–aphasia treatment efficiency using the American Speech-Language-Hearing Association Quality of Communication Life Scale. We also calculated the associated cost of that change in relationship with the change of aphasia impairment using a sample of PWA who received community-based telerehabilitation. Cost of QoL improvement from the intervention was calculated accounting for differences in age, time post onset, aphasia severity, and aphasia type.

Results:
PWA that exhibited more severe aphasia impairment experienced larger QoL improvement than those at lower impairment levels. Similarly, the average cost of improvement in QoL was lower for those more severe aphasia.

Conclusions:
Changes in aphasia-related QoL captures the impact of communication disorders on QoL, and the cost associated with the change. Measurement of aphasia-related QoL will allow clinicians and researchers to measure aphasia treatment outcomes and the cost effectiveness of those treatments using a commonly reported patient outcome—QoL.
Laboratory Findings, Medical Imaging, and Clinical Outcome in Children with Cerebral Sinus Venous Thrombosis
Authors: Glonnegger Hannah , Glatthaar Nicole , Eckenweiler Matthias , Barth Michael , Uhl Markus , Büchsel Martin , Zieger Barbara 
Published: November 2022

Abstract
Introduction Cerebral sinus venous thrombosis (CSVT) is a rare disease, especially in children. Therefore, thrombophilia markers, risk factors, treatment strategy, and MRI, as well as clinical outcome need further investigation to support future diagnostic and therapeutic guidelines for children.
Methods We retrospectively identified all children with CSVT treated in our center between January 1, 2000, and December 31, 2015. Risk factors and laboratory findings were investigated. Furthermore, outcome and treatment satisfaction were evaluated using magnetic resonance imaging (MRI) analyses and a modified questionnaire.
Results All 43 patients, who agreed to participate, were treated with therapeutic levels of heparin; 86% of children had an increased risk for thromboembolic events upon onset of CSVT (acute disease: 58.1%, perinatal risk factors: 9.3%, medical intervention/immobility: 14%, chronic disease: 16.3%). Thrombophilia markers showed positive results (e.g., reduced values for protein C/S, factor-V–Leiden mutation) in 58% of children at the time of CSVT diagnosis but dropping to 20.9% over the course of the disease. Forty-two of 43 patients received MRI follow-ups and the outcome showed complete recanalization in 69% of the patients and partial recanalization in 31%. At the onset of CSVT, 88% of patients reported restrictions in everyday life due to CSVT; at follow-up this percentage declined to 18%. Satisfaction with the outcome among parents/patients according to the questionnaire was high with 1.7 (German school grades from 1 to 6).
Conclusions All 42 children with MRI follow-up demonstrated complete or partial recanalization under anticoagulation. This positive result underlines the need for future studies on anticoagulation to optimize therapy regimens of pediatric CSVT.
Continuous Glucose Monitoring and Other Wearable Devices to Assess Hypoglycemia among Older Adult Outpatients with Diabetes Mellitus
Authors: Weiner Michael , Adeoye Philip , Boeh Margaret J. , Bodke Kunal , Broughton Jessica , Butler Anietra R. , Dafferner Mackenzie L. , Dirlam Lindsay A. , Ferguson Denisha , Keegan Amanda L. , Keith NiCole R. , Lee Joy L. , McCorkle Corrina B. , Pino Daniel G. , Shan Mu , Srinivas Preethi , Tang Qing , Teal Evgenia , Tu Wanzhu , Savoy April , Callahan Christopher M. , Clark Daniel O. 
Published: November 2022

Abstract
Background Hypoglycemia (HG) causes symptoms that can be fatal, and confers risk of dementia. Wearable devices can improve measurement and feedback to patients and clinicians about HG events and risk.
Objectives The aim of the study is to determine whether vulnerable older adults could use wearables, and explore HG frequency over 2 weeks.
Methods First, 10 participants with diabetes mellitus piloted a continuous glucometer, physical activity monitor, electronic medication bottles, and smartphones facilitating prompts about medications, behaviors, and symptoms. They reviewed graphs of glucose values, and were asked about the monitoring experience. Next, a larger sample (N = 70) wore glucometers and activity monitors, and used the smartphone and bottles, for 2 weeks. Participants provided feedback about the devices. Descriptive statistics summarized demographics, baseline experiences, behaviors, and HG.
Results In the initial pilot, 10 patients aged 50 to 85 participated. Problems addressed included failure of the glucometer adhesive. Patients sought understanding of graphs, often requiring some assistance with interpretation. Among 70 patients in subsequent testing, 67% were African-American, 59% were women. Nearly one-fourth (23%) indicated that they never check their blood sugars. Previous HG was reported by 67%. In 2 weeks of monitoring, 73% had HG (glucose ≤70 mg/dL), and 42% had serious, clinically significant HG (glucose under 54 mg/dL). Eight patients with HG also had HG by home-based blood glucometry. Nearly a third of daytime prompts were unanswered. In 24% of participants, continuous glucometers became detached.
Conclusion Continuous glucometry occurred for 2 weeks in an older vulnerable population, but devices posed wearability challenges. Most patients experienced HG, often serious in magnitude. This suggests important opportunities to improve wearability and decrease HG frequency among this population.
Acoustic Measurements of Speech and Voice in Men with Angle Class II, Division 1, Malocclusion
Authors: Viegas Flávia , Camargo Zuleica , Viegas Danieli , Guimarães Glaucio Serra , Luiz Ronir Raggio , Ritto Fabio , Simões-Zenari Marcia , Nemr Katia 
Published: November 2022

AbstractIntroduction The acoustic analysis of speech (measurements of the fundamental frequency and formant frequencies) of different vowels produced by speakers with the Angle class II, division 1, malocclusion can provide information about the relationship between articulatory and phonatory mechanisms in this type of maxillomandibular disproportion.Objectives To investigate acoustic measurements related to the fundamental frequency (F0) and formant frequencies (F1 and F2) of the oral vowels of Brazilian Portuguese (BP) produced by male speakers with Angle class II, division 1, malocclusion (study group) and compare with men with Angle class I malocclusion (control group).Methods In total, 60 men (20 with class II, 40 with class I) aged between 18 and 40 years were included in the study. Measurements of F0, F1 and F2 of the seven oral vowels of BP were estimated from the audio samples containing repetitions of carrier sentences. The statistical analysis was performed using the Student t-test and the effect size was calculated.Results Significant differences (p-values) were detected for F0 values in five vowels ([e], [i], [ᴐ], [o] and [u]), and for F1 in vowels [a] and [ᴐ], with high levels for class II, division 1.Conclusion Statistical differences were found in the F0 measurements with higher values in five of the seven vowels analysed in subjects with Angle class II, division 1. The formant frequencies showed differences only in F1 in two vowels with higher values in the study group. The data suggest that data on voice and speech production must be included in the protocol's assessment of patients with malocclusion.