bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolation and test of novel yeast strains with lignin usage capability and phenolic compound resistance
Authors: Bautista‐Guerrero Anaid , Lara‐Diaz Rene A. , Pihen Valérie , Bandala Erick R. , Sanchez‐Sala Jose Luis 
Published: October 2022

AbstractFive yeast fungi strains (i.e., two Cryptococcus albidus, one Candida guillermondii, and two Candida tropicalis) were isolated from sugarcane and tested for their use of lignin as sole carbon source and their potential to grow in the presence of phenol and phenol derivatives (i.e., pentachlorophenol and p‐nitrophenol). The full set of isolated yeasts showed ligninolytic activity, achieving at least 36% lignin degradation after 25 days. The C. albidus JS‐B1 strain had the highest ligninolytic activity, achieving 27% lignin degradation within 4 days. This increased activity was associated with the production of ligninolytic laccase enzymes. All the tested yeast fungi strains showed growth in the presence of high concentrations of phenolic compounds (i.e., 900 mg/L phenol, 200 mg/L p‐nitrophenol, 50 mg/L pentachlorophenol) and showed significant potential for lignin and lignin by‐product degradation. Each of these five strains has the potential to be used in biological treatment processes for contaminated effluents from paper pulping and bleaching or phenol and phenol‐derivative biodegradation processes for other industrial wastewater effluents.
Tumor‐derived extracellular vesicles confer 5‐fluorouracil resistance in esophageal cancer via long noncoding RNA AC116025.2 delivery
Authors: Zhang Shuyao , Liu Shaojie , Ren Jingqing , Zhang Hanshuo , Chen Song , Chen Yun , Zhang Shengqi , Chen Wang , Xu Chengcheng , Zhong Shilong , Liu Sulin , Lin Chaoxian 
Published: October 2022

Abstract5‐Fluorouracil (5‐FU) resistance is one of the main causes for treatment failure in esophageal cancer (EC). Here, we intended to elucidate the mechanism of tumor‐derived extracellular vesicles (TEVs)‐encapsulated long noncoding RNAs (lncRNAs) AC116025.2 in 5‐FU resistance in EC. EVs were isolated from the serum samples of EC patients and HEEC, TE‐1, and TE‐1/5‐FU cells, followed by RT‐qPCR detection of AC116025.2 expression in EVs. The relationship among AC116025.2, microRNA (miR)‐4496, and SEMA5A was evaluated. Next, EC cells were cocultured with EVs, followed by lentivirus transduction and plasmid transfection for studying the role of TEVs‐AC116025.2 in EC cells in relation to miR‐4496 and SEMA5A. Tumor formation in nude mice was applied for in vivo confirmation. Elevated AC116025.2 expression was seen in the EVs from the serum of 5‐FU insensitive patients and from 5‐FU‐resistant EC cells. Mechanistically, AC116025.2 bound to miR‐4496 that inversely targeted SEMA5A in EC cells. EVs‐oe‐AC116025.2 augmented EC cell viability, colony formation, and 5‐FU resistance, but diminished their apoptosis through miR‐4496‐mediated SEMA5A. Furthermore, EVs‐oe‐AC116025.2 augmented tumor formation and 5‐FU resistance of EC cells in vivo. Conclusively, our data offered evidence of the promoting mechanism of TEVs in the 5‐FU resistance of EC by delivering AC116025.2.
The impact of local gambling preferences on firm‐level environmental violations: Evidence from China
Authors: Zuo Jingjing , Qiu Baoyin 
Published: October 2022

AbstractWe examine the impact of local gambling preferences on firms' environmental violations using a sample of Chinese firms. Our findings suggest that firms in regions with high gambling preferences have higher environmental and continuous environmental violations. The results are robust to using two stage least square (2SLS) regression analysis, a propensity score matching sample, other robustness tests, and excluding alternative explanations of social responsibility and financial pressure. Further analysis shows that the impact of gambling preferences on environmental violations is more salient for firms with high managerial overconfidence and low environmental awareness. Hence, the illusion of control and underestimating the punishment costs are underlying causes.
A posteriori error estimations and convergence criteria in fast Fourier transform‐based computational homogenization
Authors: Ferrier Renaud , Bellis Cédric 
Published: October 2022

AbstractA stopping criterion for fast Fourier transform (FFT)‐based iterative schemes in computational homogenization is proposed and investigated numerically. This criterion is based on the separate evaluation and comparison of the discretization and iteration errors on the computed fields. Some estimators for these errors are proposed and their performances are assessed on a set of 2D problems in the frameworks of both the classical FFT‐based methods and these that use a modified version of the featured Green's operator. In particular, two novel strategies for estimating the discretization error are investigated: either using an image processing approach or transposing to the FFT‐based setting the constitutive relation error that is well‐established in the context of the finite element method. It is then shown that the resulting stopping criterion leads to a better control of the global error on the computed effective property compared to the classical criterion based on the residual of the iterative scheme alone.
Early time‐restricted feeding improves high‐density lipoprotein amount and function in nonhuman primates, without effects on body composition
Authors: Kavanagh Kylie , Bashore Alexander C. , Davis Matthew A. , Jorgensen Matthew J. , McClouth Christopher J. , Beavers Daniel A. , Parks John S. 
Published: October 2022

AbstractObjectiveTime‐restricted feeding (TRF), whereby caloric intake is limited to a <12‐hour window, is a potential regimen to ameliorate metabolic syndrome and cardiovascular disease (CVD) risk co‐occurring with aging and with obesity. Early TRF (eTRF; early morning feeding followed by overnight fasting) times calorie consumption with hepatic circadian gene expression rhythms. Brief TRF trials demonstrate that high‐density lipoprotein (HDL) cholesterol increases similar to diet/exercise interventions, which may impart beneficial CVD effects. Using a nonhuman primate (NHP) model, the efficacy of eTRF to raise HDL and increase plasma cholesterol efflux capacity (CEC) (primarily mediated by cholesterol efflux to HDL particles, a process that is inversely associated with CVD risk) was examined.MethodsAdult (8–16 years old, n = 25) and geriatric (≥17 years old) NHPs were randomized to ad libitum feeding or eTRF for 12 months, and relevant body composition, glycemic control, and plasma HDL cholesterol levels and CEC were measured.ResultsImpaired CEC was found in geriatric NHPs. eTRF induced larger‐sized HDL particles, increased HDL apolipoprotein A‐1 content, lowered triglyceride concentrations, and increased plasma CEC (primarily to HDL particles) in both adult and geriatric NHPs without changes in glycemic control or body composition.ConclusionsA beneficial effect of eTRF on increasing HDL CEC in NHPs was demonstrated.
Alcohol Price Floors and Externalities: The Case of Fatal Road Crashes
Authors: Francesconi Marco , James Jonathan 
Published: October 2022

AbstractIn May 2018, Scotland introduced a minimum unit price on alcohol. We examine the impact of this policy on traffic fatalities and drunk driving accidents. Using administrative data on the universe of vehicle collisions in Britain and a range of quasi‐experimental modeling approaches, we do not find that the policy had an effect on road crash deaths and drunk driving collisions. The results are robust to several sensitivity exercises. There is no evidence of effect heterogeneity by income and other predictors of alcohol consumption or cross‐border effects. A brief discussion of the policy implications of our findings is provided.
Sacrococcygeal teratoma: Long‐term outcomes. A UK CCLG Surgeons Group Nationwide Study
Authors: Braungart Sarah , James Eleanor Ca , Powis Mark , Gabra Hany ,   CCLG Surgeons Collaborators, Losty Paul D. 
Published: October 2022

AbstractAimSacrococcygeal teratoma (SCT) is a rare paediatric germ cell tumour (1:40,000). Long‐term data regarding urinary tract and bowel function after SCT resection is limited to few studies. A UK Children's Cancer and Leukaemia Group (CCLG) Surgeons multicentre study aimed to critically analyse long‐term functional outcomes in patients following resection of SCT.MethodsNationwide study of UK paediatric surgical oncology centres using a standardised data collection form. All index cases of newborn infants and children <16 years with SCT diagnosis during 2005–2015 were included.Results165 SCT patients treated at 14 UK paediatric surgical oncology centres were included. Median age at presentation was 1 day [interquartile range, IQR: 0–25]; median age at surgery was 10 days [IQR: 4–150]. One hundred seventeen (70%) were female and 48 (30%) male. Antenatal diagnosis was made in 44% index cases. Total 59% of patients were Altman Stage I or II lesions. Follow‐up data were available in 83% cases. Tumour recurrence occurred in 13 (7%) patients at median age 13 months [IQR: 8.75–30 months]. Fifty‐nine (36%) of 165 patients had documented adverse bladder or bowel dysfunction. Twenty‐two (37%) cases required urinary clean intermittent catheterisation (CIC) urology health care, with eight patients (14%) needing operative intervention to control management of bowel dysfunction.ConclusionThis UK CCLG study showed 36% of SCT patients develop bladder or bowel dysfunction after primary tumour resection. Functional assessment of bladder and bowel function is mandatory during after‐care follow‐up of all SCT patients. A multidisciplinary care pathway, with surgeon speciality groups including surgical oncology, paediatric urology and paediatric colorectal specialists, is strongly advised to facilitate ‘best practice’ monitoring of long‐term health and improve patient quality of life (QoL) into adulthood.
Investigation on the sound absorption of multilayered woven and nonwoven fabrics with different bonding conditions
Authors: Wang Jingshu , Tang Xiaoning 
Published: October 2022

AbstractIn this study, multilayer composite was fabricated by the lamination of woven and nonwoven fabrics for sound absorption applications. These fabrics exhibited different weaving densities and thicknesses, and were compounded through different methods including adhesives bonding, stich bonding, and facile plying‐up. The structure, mechanical, and sound absorption properties of laminated composites were investigated. It was found that the construction form plays an important role for enhancing the properties of multilayered composite. The sound absorption efficiency of multilayered composite can be improved by optimizing the combination of woven and nonwoven fabrics. This work has provided a valuable reference for the future development of sound absorption materials, and is also benefit for the utilization of textiles in noise reduction engineering.
Detection of disease‐causing CFTR variants in state newborn screening programs
Authors: McGarry Meghan E. , Ren Clement L. , Wu Runyu , Farrell Philip M. , McColley Susanna A. 
Published: October 2022

AbstractBackgroundNewborn screening (NBS) algorithms for cystic fibrosis (CF) vary in the United State of America and include different cystic fibrosis transmembrane conductance regulator (CFTR) variants. CFTR variant distribution varies among racial and ethnic groups.ObjectiveOur objectives were to identify differences in detection rate by race and ethnicity for CFTR variant panels, identify each US state detection rate for CFTR variant panels, and describe the rate of false‐negative NBS and delayed diagnoses by race and ethnicity.MethodsThis is a cross‐sectional analysis of the detection rate of at least 1 CFTR variant for seven panels by race and ethnicity in genotyped people with CF (PwCF) or CFTR‐related metabolic syndrome (CRMS)/CFTR‐related disorders in CF Foundation Patient Registry (CFFPR) in 2020. We estimated the case detection rate of CFTR variant panels by applying the detection rate to Census data. Using data from CFFPR, we compared the rate of delayed diagnosis or false‐negative NBS by race and ethnicity.ResultsFor all panels, detection of at least 1 CFTR variant was highest in non‐Hispanic White PwCF (87.5%−97.0%), and lowest in Black, Asian, and Hispanic PwCF (41.9%−93.1%). Detection of at least 1 CFTR variant was lowest in Black and Asian people with CRMS/CFTR‐related disorders (48.4%−64.8%). States with increased racial and ethnic diversity have lower detection rates for all panels. Overall, 3.8% PwCF had a false‐negative NBS and 11.8% had a delayed diagnosis; Black, Hispanic, and mixed‐race PwCF were overrepresented.ConclusionCFTR variant panels have lower detection rates in minoritized racial and ethnic groups leading to false‐negative NBS, delayed diagnosis, and likely health disparities.
You Oughta Know: Examining Author Geography and Gender in Information Science
Authors: Buchanan George , McKay Dana 
Published: October 2022

AbstractPublication is a vital part of the career of any researcher. There is an increasing awareness that the presented gender of authors can impact their acceptance at competitive venues, and also influence the support they receive to participate in conferences. Similarly, geography and the associated costs of travel to conferences also impact the likelihood a potential author will submit to a conference. Recent research has examined these impacts in the context of related disciplines within computing and considered the gender profile of reviewers and authors at the iConference. This paper examines the impact of gender and geography on the representation of authors in the ASIST Annual Meeting and the JASIST journal. Through an evaluation of the first authors of accepted papers or articles, we assess the relative representation of genders, and the degree to which conference location impedes or enables authors from different regions. Our findings provide a foundation for the information science community to work towards better representation of female and international authors.
Understanding the Information Creation Practices of LGBTQIA+ Community Health Workers
Authors: Kitzie Vanessa L. , Vera A. Nick , Wagner Travis L. 
Published: October 2022

AbstractThis paper reports on preliminary findings from an action research project partnering health sciences librarians with community health workers (CHWs) who are LGBTQIA+ to create information resources for the CHW’s community. Findings report on twelve virtual semistructured interviews with CHWs from South Carolina and eleven virtual brainstorming meetings between CHWs and health sciences librarians. The authors analyzed verbatim interview and meeting transcripts using a combination of deductive and inductive qualitative coding. Findings demonstrate 1) external barriers constrain and motivate information creation; 2) the presence of preexisting information, knowledge, and resources within the CHWs’ communities; 3) that CHW‐librarian pairs brainstormed how to codify and iterate what already exists; 4) that librarians adopted a reference role when brainstorming and suggested resource ideas within and outside of the CHWs’ communities. Implications include strategies that researchers and practitioners can adopt to leverage existing experiential and embodied knowledge within LGBTQIA+ communities.
Talk it Out: Teen Reactions to a Supportive Conversational Agent
Authors: Lopatovska Irene , Turpin Olivia , Yoon Ji Hee , Brown Diedre , Vroom Laura 
Published: October 2022

AbstractCOVID‐19 measures of isolation exacerbated the negative feeling, particularly in younger and older populations. We tested a voice conversational agent designed to support teens by offering interactions based on five types of behavioral interventions (compassion, self‐compassion, positive psychology, mindfulness, and humor), and examined teen reactions to these interventions. Thirty‐nine adolescents were asked to assess one randomized interaction a day for fifteen days. All five intervention types received positive ratings, with self‐compassion scoring the highest and compassion scoring the lowest by the participants. Participants shared more positive than negative feedback about the interaction scenarios, the perceived agent’s personality and conversational flow. Positive feedback emphasized enjoyment and benefits of the interaction, empathetic traits in the agent’s responses, a sense of validation, and moments for self‐reflection fostered by the interactions. Participants enjoyed the conversation flow that felt similar to a natural conversation. Negative comments generally revolved around perception of the impersonal agent, inappropriate pace of conversation (too slow/fast) or number of conversational turns, and dislike of some interaction topics. Recommendations based on this exploratory work are included.
Banned, Challenged, Questioned, or Lost? Information Access and the Path to an Information‐Resilient Society: ASIS&T Midwest Regional Chapter
Authors: Brannon Brittany , Bossaler Jenny , Dickey Timothy J. , Hajibayova Lala , Kohlburn Joe , Oltmann Shannon M. , Smith Andrew J. M. 
Published: October 2022

AbstractHistorically, librarians and information professionals have professed and supported tenets of free thought and free access to all information. Guides, literature, conference sessions, and classroom exercises help guide LIS students and librarians through the provision of controversial materials. However, information professionals work within the political and practical boundaries of their institutions. They rely on imperfect and mediated technologies for access to information and communication. The reality is that such constraints, as well as external politics and broader societal and cultural challenges, can and do affect access to information. Librarians are thus limited in their impact by both internal and external factors.This panel joins the perspectives of LIS researchers and practitioners. The discussion will demonstrate disparate threads that exemplify current research on information access challenges, successes, and opportunities in a variety of contexts. Part of contributing to an information‐resilient society is being aware of the many ways that society censors or limits access to ideas and knowledge. The panel will discuss ways to create more equitable access to technology and digital information, provision of health and wellness information, the impact of user‐generated social media reading recommendations, persistent access to dissertation research information, and the hotly contested space of drag story‐times at libraries. The research projects illustrate a wellspring of opportunities for resistance against societal limitations on knowledge and illustrate ways to reinforce core values of the profession.
Professional Development in Crisis: Toward Resilient Society
Authors: Rorissa Abebe , Mawire Blessing , Shah Chirag , Sonnenwald Diane , Khazaree Emad , Imeri Aylin , Hilal Imane 
Published: October 2022

AbstractProfessional development is one of the pillars of personal and professional success because it is the catalyst for professional fulfillment and a way to improve one's skills and excel professionally. However, this subject is not addressed enough in academic courses, therefore students and new recruits start learning while being challenged without strong enough prerequisites to support them. The objective of the panel is to gather ideas from different scholars and professionals; to exchange ideas and experiences around the different themes of this subject to empower students and professionals in their early career stages and make them more resilient in a hyper‐competitive society and uncertain world.
Information Needs of Blue‐Collar Workers: Welding Challenges and the Potential of Smart Welding Tools
Authors: Hill Katherine M. , Tunis Rachel , Pejlatowicz Pablo M. , Fleischmann Kenneth R. , Greenberg Sherri R. , Longoria Raul G. , Bendana Jose 
Published: October 2022

AbstractResearch on work and occupations in the information field have largely focused on white‐collar jobs. Little is known about the information and technology experiences and behaviors of workers in blue‐collar jobs. This study examines the user experiences of current welding tools and welding training and asks how integration of information feedback through smart technology in welding tools can help welders do their jobs safer, easier, and faster. We conducted 14 in‐depth interviews with members of Longhorn Racing, a student organization that designs, builds, and tests race cars. Participants experienced frustrations with the dangerous and technical setup and the limited vision and information feedback from welding tools. Many argued that the integration of smart technology into welding tools could improve their experience. These innovations could lead to faster training and reduced attrition in the welding industry. Further, this research points to the urgent need for more research on blue‐collar workers in the information field.
Human‐Driven Models: A Case Study of Geologists as They Engage with Data for Decision Making
Authors: Keefer Donald A. , Blake Catherine 
Published: October 2022

AbstractThe value of geologic data is well established and demonstrated by efforts such as EarthChem and EarthCube. Although these communities are active in the documentation and preservation of geologic data, more work is needed to understand how geologists use this data to address specific problems. In this preliminary analysis, we focus on the information behaviors of professional geologists as they engage with multiple data streams to make decisions. Using semi‐structured interviews and grounded theory, our findings document how a single data point can drive changes to existing models. Responses also show that geologists view their experiences in data collection as critical and they use their knowledge and experience to iteratively re‐assess the context and fitness of their data as they search for coherent interpretations that resolve data‐model conflicts.
Integrated but Isolated: Implications from a Systematic Review of the Access Control Ecosystem for Individual Participant Data in Clinical Studies
Authors: Lee Jian‐Sin , Jeng Wei 
Published: October 2022

AbstractWhile the importance of open science is further highlighted during the pandemic, the challenges of managing and sharing individual participant data (IPD) derived from clinical studies never cease. The nature of IPD, e.g., confidentiality or sensitivity, makes it difficult to maintain a good balance between data sharing and individual privacy protection. To date, many access control mechanisms for IPD do exist, but conventional solutions and services are deemed scattered and still not in place. To gain a more comprehensive understanding of the IPD sharing tensions, we conducted a systematic literature review with 64 academic publications that discuss the access control mechanisms built for IPD in clinical studies. Via the knowledge infrastructure (KI) framework, we identified nine key aspects involved and the relationships between major stakeholders in the IPD access control ecosystem. Our results anticipate informing the future design of an IPD management checklist that data professionals can use to guide their clients when releasing sensitive biomedical data.