bluuebunny/crossref_metadata_2025_split huggingface dataset:
Book Reviews
Authors: Williams Isabelle , Esson Florence , Cai Yunci , Davidson Lee , Gorbachev Valentin , Jones Nathan , Kernohan Kirsty , Weber Heidi , Zhao Xiaomei , Li Xuelei 
Published: October 2022

Women Mean Business: Colonial businesswomen in New Zealand, Catherine Bishop. Dunedin: Otago University Press, 2019.Imagining Decolonisation, Rebecca Kiddle with Bianca Elkington, Moana Jackson, Ocean Ripeka Mercier, Mike Ross, Jennie Smeaton, and Amanda Thomas, eds. Wellington: Bridget Williams Books, 2020.Cosmopolitan Ambassadors: International Exhibitions, Cultural Diplomacy and the Polycentral Museum, Lee Davidson and Leticia Pérez Castellanos. Wilmington, DE: Vernon Press, 2019.Museums, International Exhibitions and China’s Cultural Diplomacy, Linda Da Kong. London: Routledge, 2021.Curating (Post-)Socialist Environments, Philipp Schorch and Daniel Habit. Bielefeld: Transcript Verlag, 2021.A Cultural Arsenal for Democracy: The World War II Work of US Museums, Clarissa J. Ceglio. Boston: University of Massachusetts Press, 2022.Mobile Museums: Collections in Circulation, Felix Driver, Mark Nesbitt, and Caroline Cornish, eds. London: UCL Press, 2021.Écrire la muséologie: Méthodes de recherche, rédaction, communication [Writing museology, Research methods, writing, communication], François Mairesse and Fabien Van Geert. Paris: Presses Sorbonne Nouvelle Ed, 2021.Cultural Renewal in Cambodia: Academic Activism in the Neoliberal Era, Philippe Peycam. Leiden: Brill, 2020.Animal Classification in Central China: From the late Neolithic to the early Bronze Age, Ningning Dong. Oxford: BAR Publishing, 2021.
Media Gambar Animasi Pada Game Edukasi Untuk Meningkatkan Minat Belajar
Authors: Arumsari Rahayu , Cep Lukman Rohmat  , Ruli Herdiana  , Iin  , Umi Hayati  
Published: October 2022

Penggunaan game edukasi saat ini terus menjadi bahan ajar yang diminati oleh para guru, dengan metode pembelajaran ini dapat menumbuhkan kreativitas para siswa untuk meningkatkan kualitas pendidikan yang lebih baik. Game edukasi memiliki tujuan untuk merangsang kecerdasan otak anak, sebagai penyeimbang otak kanan dan otak kiri. Selain itu juga dengan menggunakan game edukasi, memiliki konsep yang menarik dan bermanfaat, sehingga bagi para siswa-siswi merasa senang dan dapat menemukan hal baru didalamnya. Masalah dalam penelitian ini untuk pelajaran bahasa Indonesia adalah siswa lebih menyukai materi secara visual atau dengan gambar animasi, karena sebagai guru pun harus dapat menyesuaikan suasana hati siswa-siswi. Pada dasarnya game edukasi ini seperti sedang bermain namun tetap ada pelajaran yang dapat diambil. Tujuan dari penelitian ini untuk membuat game edukasi yang menarik agar para siswa-siswi di sekolah dasar ini agar dapat lebih semangat untuk belajar. Metode yang digunakan yaitu ADDIE (Analisis, Design, Development, Implementasi, Evaluasi), model ini dapat digunakan untuk berbagai macam produk kegiatan pembelajaran dan dengan game edukasi ini dapat menjadi bahan evaluasi nilai akhir. Hasil dari penelitian ini adalah berdasarkan hasil dalam pembuatan game animasi menggunakan software Smart Apps Creator, mengahasilkan game yang mudah untuk digunakan untuk siswa-siswa SD kelas 2. Hasi dari uji yang dihitung menggunakan perhitungan SUS (system usability scale) dari 24 responden penilaian yang diberikan untuk kelayakan game edukasi bahasa Indonesia memperoleh nilai 82 , Dengan Acceptability Ranges didapat Acceptable, versi Adjectives Rating termasuk grade Best imaginable dan Interpretasi dengan Grade Scale maka skor 82 masuk kedalam rating (A).
Recensioni
Authors: Moro Renato , Naso Pierpaolo , Botti Alfonso 
Published: October 2022

In questo numero:Giovanni Aldobrandini, Il buono e il cattivo tempo. Joseph Chamberlain e il progetto riformista e imperialista nell'Inghilterra tardovittoriana (1789-1915) (Renato Moro)Fabrizio Rudi, Soglie inquiete. L'Italia e la Serbia all'inizio del Novecento (1904-1912) (Pierpaolo Naso)Paolo Zanini, Il "pericolo protestante". Chiesa e cattolici italiani di fronte alla questione della libertà religiosa (1922-1955) (Alfonso Botti)
A INCLUSÃO (EXCLUSÃO) SOCIAL DOS ALUNOS COM DEFICIÊNCIA EM SALA DE AULA
Authors: Serighelli Marco André , Araldi Mariana 
Published: October 2022

O artigo tem como objetivo identificar e compreender a realidade escolar no processo de inclusão (exclusão) de alunos portadores de deficiência que estão inseridos no ensino regular, em duas escolas de ensino fundamental do município de Videira – SC. Para tal foi realizado leituras e estudos sobre os aspectos teóricos e legais que abarcam a inclusão social de crianças com deficiência. Também foram realizadas observações semiestruturadas in loco, bem como conversas com profissionais que atendem os alunos com deficiência ou dificuldades de aprendizagem. Os desdobramentos das observações e das informações coletadas apontam que o processo de inclusão social dos alunos com deficiência ou alguma dificuldade de aprendizagem ainda precisa de ajustes no sentido de não seguir o caminho inverso de sua proposta.
Palavras-chave: Inclusão social. Educação Básica. Deficiência.

ABSTRACT
The article aims to identify and understand the school reality in the inclusion (exclusion) process of students with disabilities who are inserted in regular education, in two elementary schools in the municipality of Videira - SC. To this end, readings and studies were carried out on the theoretical and legal aspects that encompass the social inclusion of children with disabilities. Semi-structured observations were also carried out on the spot, as well as conversations with professionals who assist students with disabilities or learning difficulties. The consequences of the observations and information collected indicate that the process of social inclusion of students with disabilities or some learning difficulty still needs adjustments in order not to follow the opposite path of its proposal.
Keywords: Social inclusion. Basic Education. Disability.
Cardiac involvement in patients 1 year after recovery from moderate and severe COVID-19 infections
Authors: Qiao Jinhan , Zhao Peijun , Lu Jianyao , Huang Lu , Ma Xiaoling , Zhou Xiaoyue , Xia Liming 
Published: October 2022

BackgroundSome patients suffered persistent cardiac symptoms after hospital discharge following COVID-19 infection, including chest tightness, chest pain, and palpitation. However, the cardiac involvement in these patients remains unknown. The purpose of this study was to investigate the effect of COVID-19 infection on the cardiovascular system after 1 year of recovery in patients hospitalized with persistent cardiac symptoms.Materials and methodsIn this prospective observational study, a total of 32 patients who had COVID-19 (11 diagnosed as severe COVID-19 and 21 as moderate) with persistent cardiac symptoms after hospital discharge were enrolled. Contrast-enhanced cardiovascular magnetic resonance (CMR) imaging was performed on all patients. Comparisons were made with age- and sex-matched healthy controls (n = 13), and age-, sex- and risk factor-matched controls (n = 21). Further analysis was made between the severe and moderate COVID-19 cohorts.ResultsThe mean time interval between acute COVID-19 infection and CMR was 462 ± 18 days. Patients recovered from COVID-19 had reduced left ventricular ejection fraction (LVEF) (p = 0.003) and increased extracellular volumes (ECVs) (p = 0.023) compared with healthy controls. Focal late gadolinium enhancement (LGE) was found in 22 (68.8%) patients, mainly distributed linearly in the septal mid-wall or patchily in RV insertion point. The LGE extent in patients with severe COVID-19 was higher than that in patients with moderate COVID-19 (p = 0.009).ConclusionThis 1-year follow-up study revealed that patients with persistent cardiac symptoms, after recovering from COVID-19, had decreased cardiac function and increased ECV compared with healthy controls. Patients with COVID-19 predominately had a LGE pattern of septal mid-wall or RV insertion point. Patients with severe COVID-19 had greater LGE extent than patients with moderate COVID-19.
A meta-analysis of the diagnostic value of microRNA for hypertensive left ventricular hypertrophy
Authors: Fei Su-Hai , Liu Zhen-Feng , Xie Hai-Ning , Tong Jia-Ni , Fang Zheng-Mei , Chen Yan , Yao Ying-Shui 
Published: October 2022

In this study, the diagnostic value of microRNAs (miRNAs) for hypertension (HTN) with left ventricular hypertrophy (LVH) were evaluated by meta-analysis. A correlation study of the diagnostic value of miRNAs in HTN with LVH was conducted using a computer search of the China Knowledge Network (CNKI), Wanfang, VIP, China Biomedical Literature Database (CBM), PubMed, Web of Science, and Embase. Studies from the time of database creation to May 2022 were evaluated. The quality assessment of diagnostic accuracy studies-2 (QUADAS-2) tool in RevMan 5.3 was used to evaluate the quality of the literature, and Meta-Disc 1.4 and Stata 16.0, were used to calculate the combined sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic advantage ratio (DOR), and their 95% confidence intervals. Subject working characteristic curves were plotted and the area under the curve (AUC) was calculated using Stata 16.0. Seven publications and 8 studies were included. miRNA diagnoses of HTN with LVH had SENcombined = 0.84, SPEcombined = 0.80, PLRcombined = 4.2, NLRcombined = 0.20, DORcombined = 21, and AUCcombined = 0.89. Subgroup analysis showed that the sensitivity of plasma miRNA for the diagnosis of HTN with LVH was 0.85, which was higher than that of serum which was 0.83. The specificity of serum miRNA for the diagnosis of HTN with LVH was 0.82, which was higher than that of plasma which was 0.78, and the diagnostic accuracy of miRNA in serum DOR was 23, which was higher than that of plasma DOR which was 20. In the diagnosis of HTN with LVH, miRNA has high sensitivity and specificity and is a better biological marker.Systematic review registrationhttp://www.crd.york.ac.uk/PROSPERO/, CRD42022346686.
The development of the Pan American Health Organization digital health specialist on alcohol use
Authors: Monteiro Maristela G. , Pantani Daniela , Pinsky Ilana , Hernandes Rocha Thiago Augusto 
Published: October 2022

IntroductionOn 19 November 2021 the Pan American Health Organization (PAHO) developed and deployed the first-ever digital health worker dedicated to alcohol-related topics, named Pahola. This paper describes this developmental process and the first results of its uptake and interactions with the public.MethodsPAHO secured a non-exclusive worldwide license with a technology company to use their Human OS ecosystem, which enables human-like interactions between digital people and users via an application. Google Digital flow ES was used to develop the conversations of Pahola on topics related to alcohol and health, screening of alcohol risk using the AUDIT and providing a quit/cut back plan to users, along with additional treatment services and resources in each country of the Americas. A communication campaign was also implemented from launching date until 31 December 2021.ResultsPahola attracted good attention from the media, and potentially reached 1.6 million people, leading to 236,000 sessions on its landing page, mostly through mobile devices. The average time people effectively spent talking to Pahola was five minutes. Major dropouts were observed in different steps of the conversation flow.DiscussionPahola was quickly able to connect to a large worldwide population with reliable alcohol information. It could potentially increase the delivery of SBI and improve alcohol health literacy. However, its preliminary results pointed to much needed changes to its corpus and on its accessibility, which are being currently implemented.
Combined toxic effects of nitrite and ammonia on life history traits of Daphnia pulex
Authors: Yu Bo , Lyu Kai , Li Jiajia , Yang Zhou , Sun Yunfei 
Published: October 2022

Nitrite and ammonia are two of the most common toxic nitrogenous pollutants in aquatic ecosystem, which can pose a serious threat to the health of aquatic organisms. Cladocerans, as an important part of freshwater ecosystem, will inevitably be harmed by these pollutants. To evaluate the combined toxic effects of these nitrogenous pollutants on cladocerans, we simulated 15 combinations of five nitrite concentrations (0, 0.5, 2, 4, 8 mg L−1) and three ammonia concentrations (0, 0.1, 1 mg L−1) to study the changes of life history traits of Daphnia pulex exposed to these combinations for 21 days. Results showed that under the combined stress of nitrite and ammonia, the survival time of D. pulex was shortened, the time to first batch of eggs and time to first brood were delayed, the body size and tail spine length at maturation were reduced, and the total offspring and the number of broods were decreased. There were some synergistically negative effects between the two nitrogenous pollutants. The presence of ammonia reduced the tolerance of D. pulex to nitrite, and vice versa. These findings provided new insights into the combined toxic effects of nitrite and ammonia on the life history traits of cladocerans, and were of great significance for understanding the population dynamics of specific species in cladocerans community under the condition of compound nitrogenous pollutants.
Inversion and analysis of aerosol optical properties and lidar ratios based on sky-radiometer and Raman lidar measurements in Xi’an, China
Authors: Liu Jingjing , Guo Zhuqi , Zhou Luyao , Wang Longlong , Wang Jun , Yan Qing , Hua Dengxin 
Published: October 2022

The aerosol observations in Xi’an (34.25°N, 108.983°E), a typical urban site in Northwest China, were conducted using a sky-radiometer from January 2015 to March 2018. Multi-year variations of aerosol optical properties (AOPs) and lidar ratios (LRs) were simultaneously analyzed and calculated. In particular, LRs in 340 nm were compared and validated using the UV-Raman lidar (RL) measurements. During the study period, aerosol optical depth at 500 nm (AOD500) had significant seasonal variation, with a maximum value of 0.68 in winter and a minimum value of 0.59 in autumn. Ångström exponent (AE) exhibited different seasonal variation patterns, and the minimum (0.81) and maximum (1.06) values appeared in spring and summer, respectively. The spectral difference between AE400–675 and AE675–870 indicated that high AOD675 values (&gt;1.0) were affected by accidental factors (e.g., dust weather in spring and winter) and the accumulation of fine particle aerosols across all seasons. The relationship between AOD500 and AE400–870 was used to distinguish different aerosol types. Overall, mixed aerosols (MX) accounted for the largest contribution (ranging from 40.14% in autumn to 69.9% in spring), followed by biomass-burning or urban/industrial aerosols (BB/UI) (with the smallest value of 19.9% in spring, and the largest value of 43.66% in winter). Single-scattering albedo (SSAs) experienced weak seasonal variation, with a minimum in winter and a maximum in spring. The seasonal aerosol volume size distributions (VSDs) generally exhibited the trimodal patterns. The particle radius (R) of less than 0.5 μm is considered as fine mode, the coarse mode is R greater than 2.5 μm, and the middle mode is located somewhere in between them. The real CRI were ∼1.41–1.43, with no significant difference among different seasons. Besides, the LRs derived by combining sky-radiometer with Mie-scattering theory changed greatly with weather from 49.95 ± 8.89 in summer to 63.95 ± 6.77 in autumn, which were validated by RL with the errors within a certain height range of less than 10%. We confirmed the feasibility of using the LR of UV band from sky-radiometer as a reference value for the Fernald or Klett method.
Using dried blood spot on HemoTypeSC™, a new frontier for newborn screening for sickle cell disease in Nigeria
Authors: Okeke Chinwe O. , Chianumba Reuben I. , Isa Hezekiah , Asala Samuel , Nnodu Obiageli E. 
Published: October 2022

Background: HemoTypeSC is a rapid, point-of-care testing (POCT) device for sickle cell disease (SCD) that traditionally uses the capillary blood from heel stick collected at the point of testing, a procedure that makes mass screening cumbersome and less cost-effective. Using dried blood spots (DBS) on HemoTypeSC could mitigate this challenge. Therefore, this study aimed to determine the feasibility of eluting blood from DBS to read on HemoTypeSC.Methods: DBS and fresh samples from heel sticks were collected from 511 newborns at the immunization clinics of six Primary Health Centers in Abuja, Nigeria. The two samples from each newborn were analyzed using HemoType SC and then compared with the result of the isoelectric focusing (IEF) test.Results: Of the 511 newborns, 241 were males and 270 were females. Standard HemoTypeSC (using fresh samples collected from heel sticks) and HemoTypeSC using DBS identified 404 (79.0%) HbAA, 100 (19.6%) HbAS, 6 (1.2%) HbSS, and 1 (0.2%) HbAC phenotypes. The IEF tests identified 370 (72.4%) HbAA, 133 (26.0%) HbAS, 5 (1.0%) HbSS, and 3 (0.6%) HbAC phenotypes. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and overall accuracy of HemoTypeSC using DBS, compared to standard HemoTypeSC POCT was 100%. IEF method showed for AA, AS, AC phenotypes; sensitivity; 84.7%, 67%,100% respectively, specificity; 67.6%, 86%, 99% respectively, PPV; 91.2%, 53%, 50% respectively, NPV; 52.7%, 91%, 100% respectively. For SS phenotype, IEF showed 100% specificity, sensitivity, PPV and NPV.Conclusion: HemoTypeSC test using dried blood spot is as accurate as the standard point-of-care HemoTypeSC test. The use of DBS on HemoTypeSC could ensure better efficiency and cost-effectiveness in mass newborn screening for SCD.
Respiratory tract infections and risk factors for infection in a cohort of 330 patients with axial spondyloarthritis or psoriatic arthritis
Authors: Frede Natalie , Rieger Eva , Lorenzetti Raquel , Nieters Alexandra , Venhoff Ana C. , Hentze Carolin , von Deimling Marcus , Bartholomä Nora , Thiel Jens , Voll Reinhard E. , Venhoff Nils 
Published: October 2022

Respiratory tract infections (RTIs) are the most common infections in patients with rheumatic diseases under immunosuppressive treatment and may contribute to morbidity and mortality as well as increased healthcare costs. However, to date only limited data on infection risk in spondyloarthritis (SpA) patients are available. In this study we assessed the occurrence of respiratory tract infections in a monocentric real-world cohort consisting of 330 patients (168 psoriatic arthritis and 162 axial spondyloarthritis patients) and determined factors associated with increased infection risk. Out of 330 SpA patients, 89.3% had suffered from ≥ 1 upper respiratory tract infection (URTI) and 31.1% from ≥ 1 lower respiratory tract infection (LRTI) within the last two years. The most common URTIs were rhinitis and laryngitis/pharyngitis with 87.3% and 36.1%, respectively. Bronchitis constituted the most common LRTI, reported in 29.7% of patients. In a multivariate binomial logistic regression model occurrence of LRTI was associated with chronic lung disease (OR 17.44, p=0.006), glucocorticoid therapy (OR 9.24, p=0.012), previous history of severe airway infections (OR 6.82, p=0.013), and number of previous biological therapies (OR 1.72, p=0.017), whereas HLA B27 positivity was negatively associated (OR 0.29, p=0.025). Female patients reported significantly more LRTIs than male patients (p=0.006) and had a higher rate of antibiotic therapy (p=0.009). There were no significant differences between axSpA and PsA patients regarding infection frequency or antibiotic use. 45.4% of patients had required antibiotics for respiratory tract infections. Antibiotic therapy was associated with smoking (OR 3.40, p=0.008), biological therapy (OR 3.38, p=0.004), sleep quality (OR 1.13, p&lt;0.001) and age (OR 0.96, p=0.030). Hypogammaglobulinemia (IgG&lt;7g/l) was rare (3.4%) in this SpA cohort despite continuous immunomodulatory treatment.Awareness of these risk factors will assist physicians to identify patients with an increased infection risk, who will benefit from additional preventive measures, such as vaccination and smoking cessation or adjustment of DMARD therapy.
Identification of cerebrospinal fluid biomarker candidates for anti-N-methyl-D-aspartate receptor encephalitis: High-throughput proteomic investigation
Authors: Li Yuchen , Yang Keyu , Zhang Fang , Wang Jing , Shen Huijun , Liu Miaomiao , Guo Junhong , Wang Jie 
Published: October 2022

BackgroundAlthough the diagnosis is mainly dependent on the detection of anti-N-methyl-D-aspartate receptor (NMDAR) antibodies in cerebrospinal fluid (CSF) and/or serum, there was no direct correlations between anti-NMDAR antibody titers in CSF and disease severity and prognosis in anti-NMDAR encephalitis patients. Here, we aimed to extensively identify CSF biomarkers related to the occurrence, development, and prognosis of anti-NMDAR encephalitis using a high-throughput proteomic approach.MethodsA CSF cytokine antibody array containing 80 cytokines and inflammatory mediators related to immune and inflammatory responses was applied to identify biomarker candidates in individual CSF samples from a well-characterized cohort comprising patients with anti-NMDAR encephalitis (n = 6) and controls (n = 6). Validation and specific detection were performed in an extended cohort consisting of anti-NMDAR encephalitis patients (n = 13), controls (n = 13), and viral encephalitis (n = 13) by enzyme-linked immunosorbent assay (ELISA). Additionally, the levels of some inflammatory proteins in three groups in cohort 2 reported in previous literatures that may be involved in the development of anti-NMDAR encephalitis were also tested by ELISA. Correlations between candidate biomarkers and clinical characteristics of anti-NMDAR encephalitis patients were analyzed.ResultsThree differentially expressed cytokines and inflammatory mediators were screened from the 80-cytokine array in cohort 1. Functional enrichment analysis results suggested that these differentially expressed proteins were related to autophagy, immune/inflammatory responses, cell death, and other processes. In cohort 2, the elevations of cellular inhibitor of apoptosis protein-1 (cIAP-1), macrophage colony-stimulating factor (MCSF), CXC chemokine ligand 13 (CXCL13), and nucleotide binding oligomerization domain-like receptor protein 3 (NLRP3) in anti-NMDAR encephalitis were validated by ELISA. Linear regression revealed that the levels of CSF CXCL13 and cIAP-1 were positively correlated with the highest modified Rankin scale (mRS) score in the acute phase (p &lt; 0.05). The level of cIAP-1 was positively correlated with the anti-NMDAR Encephalitis One-Year Functional Status (NEOS) score (p &lt; 0.05).ConclusionThese biomarkers show promising functions to evaluate severity or prognosis of anti-NMDAR encephalitis. The biological processes of immune/inflammatory responses, altered levels of autophagy, and the tumor necrosis factor (TNF) signal pathway may be involved in the pathophysiology of anti-NMDAR encephalitis to some extent.