bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelling armed conflict risk under climate change with machine learning and time-series data
Authors: Ge Quansheng , Hao Mengmeng , Ding Fangyu , Jiang Dong , Scheffran Jürgen , Helman David , Ide Tobias 
Published: May 2022

AbstractUnderstanding the risk of armed conflict is essential for promoting peace. Although the relationship between climate variability and armed conflict has been studied by the research community for decades with quantitative and qualitative methods at different spatial and temporal scales, causal linkages at a global scale remain poorly understood. Here we adopt a quantitative modelling framework based on machine learning to infer potential causal linkages from high-frequency time-series data and simulate the risk of armed conflict worldwide from 2000–2015. Our results reveal that the risk of armed conflict is primarily influenced by stable background contexts with complex patterns, followed by climate deviations related covariates. The inferred patterns show that positive temperature deviations or precipitation extremes are associated with increased risk of armed conflict worldwide. Our findings indicate that a better understanding of climate-conflict linkages at the global scale enhances the spatiotemporal modelling capacity for the risk of armed conflict.
Insights into the client protein release mechanism of the ATP-independent chaperone Spy
Authors: He Wei , Li Xinming , Xue Hongjuan , Yang Yuanyuan , Mencius Jun , Bai Ling , Zhang Jiayin , Xu Jianhe , Wu Bin , Xue Yi , Quan Shu 
Published: May 2022

AbstractMolecular chaperones play a central role in regulating protein homeostasis, and their active forms often contain intrinsically disordered regions (IDRs). However, how IDRs impact chaperone action remains poorly understood. Here, we discover that the disordered N terminus of the prototype chaperone Spy facilitates client release. With NMR spectroscopy and molecular dynamics simulations, we find that the N terminus can bind transiently to the client-binding cavity of Spy primarily through electrostatic interactions mediated by the N-terminal D26 residue. This intramolecular interaction results in a dynamic competition of the N terminus with the client for binding to Spy, which promotes client discharge. Our results reveal the mechanism by which Spy releases clients independent of energy input, thus enriching the current knowledge on how ATP-independent chaperones release their clients and highlighting the importance of synergy between IDRs and structural domains in regulating protein function.
Formation of organic color centers in air-suspended carbon nanotubes using vapor-phase reaction
Authors: Kozawa Daichi , Wu Xiaojian , Ishii Akihiro , Fortner Jacob , Otsuka Keigo , Xiang Rong , Inoue Taiki , Maruyama Shigeo , Wang YuHuang , Kato Yuichiro K. 
Published: May 2022

AbstractOrganic color centers in single-walled carbon nanotubes have demonstrated exceptional ability to generate single photons at room temperature in the telecom range. Combining the color centers with pristine air-suspended nanotubes would be desirable for improved performance, but all current synthetic methods occur in solution which makes them incompatible. Here we demonstrate the formation of color centers in air-suspended nanotubes using a vapor-phase reaction. Functionalization is directly verified by photoluminescence spectroscopy, with unambiguous statistics from more than a few thousand individual nanotubes. The color centers show strong diameter-dependent emission, which can be explained with a model for chemical reactivity considering strain along the tube curvature. We also estimate the defect density by comparing the experiments with simulations based on a one-dimensional exciton diffusion equation. Our results highlight the influence of the nanotube structure on vapor-phase reactivity and emission properties, providing guidelines for the development of high-performance near-infrared quantum light sources.
A pediatric wrist trauma X-ray dataset (GRAZPEDWRI-DX) for machine learning
Authors: Nagy Eszter , Janisch Michael , Hržić Franko , Sorantin Erich , Tschauner Sebastian 
Published: May 2022

AbstractDigital radiography is widely available and the standard modality in trauma imaging, often enabling to diagnose pediatric wrist fractures. However, image interpretation requires time-consuming specialized training. Due to astonishing progress in computer vision algorithms, automated fracture detection has become a topic of research interest. This paper presents the GRAZPEDWRI-DX dataset containing annotated pediatric trauma wrist radiographs of 6,091 patients, treated at the Department for Pediatric Surgery of the University Hospital Graz between 2008 and 2018. A total number of 10,643 studies (20,327 images) are made available, typically covering posteroanterior and lateral projections. The dataset is annotated with 74,459 image tags and features 67,771 labeled objects. We de-identified all radiographs and converted the DICOM pixel data to 16-Bit grayscale PNG images. The filenames and the accompanying text files provide basic patient information (age, sex). Several pediatric radiologists annotated dataset images by placing lines, bounding boxes, or polygons to mark pathologies like fractures or periosteal reactions. They also tagged general image characteristics. This dataset is publicly available to encourage computer vision research.
Post-resonance backward whirl analysis in cracked overhung rotors
Authors: Alzarooni Tariq , AL-Shudeifat Mohammad , Shiryayev Oleg , Nataraj C. 
Published: May 2022

AbstractOverhung rotors usually exhibit recurrent transitions through critical whirl rotational speeds during startup and coast down operations, which significantly differ from their steady-state whirl responses. The presence of angular acceleration results in a linear-time-varying (LTV) system, which, although technically linear, still presents complexities often evinced by a nonlinear system. In general, backward whirl zones can either precede the critical forward whirl speed (termed as pre-resonance backward whirl, Pr-BW), or immediately follow the critical forward whirl speed (termed as post-resonance backward whirl, Po-BW). The Po-BW in the whirl response of a cracked overhung rotor with a breathing crack is studied here as distinct from that of geometrically symmetric configurations of other rotor systems. The equations of motion from the finite element (FE) model of an overhung rotor system with a breathing crack are numerically integrated to obtain the whirl response. The transient whirl responses with different bearing conditions are thoroughly investigated for excitation of Po-BW. The Po-BW zones of rotational speeds are determined via the wavelet transform method and full spectrum analysis (FSA) and applied to signals with added noise. The results of this work confirm the excitation of the Po-BW in cracked overhung rotors and confirm the robustness of the employed methods.
Statistical optimization, kinetic, equilibrium isotherm and thermodynamic studies of copper biosorption onto Rosa damascena leaves as a low-cost biosorbent
Authors: Fawzy Mustafa A. , Al-Yasi Hatim M. , Galal Tarek M. , Hamza Reham Z. , Abdelkader Tharwat G. , Ali Esmat F. , Hassan Sedky H. A. 
Published: May 2022

AbstractIn this study, Rosa damascena leaf powder was evaluated as a biosorbent for the removal of copper from aqueous solutions. Process variables such as the biosorbent dose, pH, and initial copper concentration were optimized using response surface methodology. A quadratic model was established to relate the factors to the response based on the Box–Behnken design. Analysis of variance (ANOVA) was used to assess the experimental data, and multiple regression analysis was used to fit it to a second-order polynomial equation. A biosorbent dose of 4.0 g/L, pH of 5.5, and initial copper concentration of 55 mg/L were determined to be the best conditions for copper removal. The removal of Cu2+ ions was 88.7% under these optimal conditions, indicating that the experimental data and model predictions were in good agreement. The biosorption data were well fitted to the pseudo-second-order and Elovich kinetic models. The combination of film and intra-particle diffusion was found to influence Cu2+ biosorption. The Langmuir and Dubinin–Radushkevich isotherm models best fit the experimental data, showing a monolayer isotherm with a qmax value of 25.13 mg/g obtained under optimal conditions. The thermodynamic parameters showed the spontaneity, feasibility and endothermic nature of adsorption. Scanning electron microscopy, energy-dispersive X-ray spectroscopy, and Fourier transform infrared spectroscopy were used to characterize the biosorbent before and after Cu2+ biosorption, revealing its outstanding structural characteristics and high surface functional group availability. In addition, immobilized R. damascena leaves adsorbed 90.7% of the copper from aqueous solution, which is more than the amount adsorbed by the free biosorbent (85.3%). The main mechanism of interaction between R. damascena biomass and Cu2+ ions is controlled by both ion exchange and hydrogen bond formation. It can be concluded that R. damascena can be employed as a low-cost biosorbent to remove heavy metals from aqueous solutions.
All-optical manipulation of the Drosophila olfactory system
Authors: Zanon Mirko , Zanini Damiano , Haase Albrecht 
Published: May 2022

AbstractThanks to its well-known neuroanatomy, limited brain size, complex behaviour, and the extensive genetic methods,Drosophilahas become an indispensable model in neuroscience. A vast number of studies have focused on its olfactory system and the processing of odour information. Optogenetics is one of the recently developed genetic tools that significantly advance this field of research, allowing to replace odour stimuli by direct neuronal activation with light. This becomes a universal all-optical toolkit when spatially selective optogenetic activation is combined with calcium imaging to read out neuronal responses. Initial experiments showed a successful implementation to study the olfactory system in fish and mice, but the olfactory system ofDrosophilahas been so far precluded from an application. To fill this gap, we present here optogenetic tools to selectively stimulate functional units in theDrosophilaolfactory system, combined with two-photon calcium imaging to read out the activity patterns elicited by these stimuli at different levels of the brain. This method allows to study the spatial and temporal features of the information flow and reveals the functional connectivity in the olfactory network.
Diffuse fibrosis and repolarization disorders explain ventricular arrhythmias in Brugada syndrome: a computational study
Authors: Biasi Niccoló , Seghetti Paolo , Tognetti Alessandro 
Published: May 2022

AbstractIn this work, we reported a computational study to quantitatively determine the individual contributions of three candidate arrhythmic factors associated with Brugada Syndrome. In particular, we focused our analysis on the role of structural abnormalities, dispersion of repolarization, and size of the diseased region. We developed a human phenomenological model capable of replicating the action potential characteristics both in Brugada Syndrome and in healthy conditions. Inspired by physiological observations, we employed the phenomenological model in a 2D geometry resembling the pathological RVOT coupled with healthy epicardial tissue. We assessed the insurgence of sustained reentry as a function of electrophysiological and structural abnormalities. Our computational study indicates that both structural and repolarization abnormalities are essential to induce sustained reentry. Furthermore, our results suggest that neither dispersion of repolarization nor structural abnormalities are sufficient on their own to induce sustained reentry. It should be noted how our study seems to explain an arrhythmic mechanism that unifies the classic repolarization and depolarization hypotheses of the pathophysiology of the Brugada Syndrome. Finally, we believe that this work may offer a new perspective on the computational and clinical investigation of Brugada Syndrome and its arrhythmic behaviour.
Inflammation and remodeling pathways and risk of cardiovascular events in patients with ischemic heart failure and reduced ejection fraction
Authors: Girerd Nicolas , Cleland John , Anker Stefan D. , Byra William , Lam Carolyn S. P. , Lapolice David , Mehra Mandeep R. , van Veldhuisen Dirk J. , Bresso Emmanuel , Lamiral Zohra , Greenberg Barry , Zannad Faiez 
Published: May 2022

AbstractPatients with heart failure (HF) and coronary artery disease (CAD) have a high risk for cardiovascular (CV) events including HF hospitalization, stroke, myocardial infarction (MI) and sudden cardiac death (SCD). The present study evaluated associations of proteomic biomarkers with CV outcome in patients with CAD and HF with reduced ejection fraction (HFrEF), shortly after a worsening HF episode. We performed a case–control study within the COMMANDER HF international, double-blind, randomized placebo-controlled trial investigating the effects of the factor-Xa inhibitor rivaroxaban. Patients with the following first clinical events: HF hospitalization, SCD and the composite of MI or stroke were matched with corresponding controls for age, sex and study drug. Plasma concentrations of 276 proteins with known associations with CV and cardiometabolic mechanisms were analyzed. Results were corrected for multiple testing using false discovery rate (FDR). In 485 cases and 455 controls, 49 proteins were significantly associated with clinical events of which seven had an adjusted FDR < 0.001 (NT-proBNP, BNP, T-cell immunoglobulin and mucin domain containing 4 (TIMD4), fibroblast growth factor 23 (FGF-23), growth differentiation factor-15 (GDF-15), pulmonary surfactant-associated protein D (PSP-D) and Spondin-1 (SPON1)). No significant interactions were identified between the type of clinical event (MI/stroke, SCD or HFH) and specific biomarkers (all interaction FDR > 0.20). When adding the biomarkers significantly associated with the above outcome to a clinical model (including NT-proBNP), the C-index increase was 0.057 (0.033–0.082), p < 0.0001 and the net reclassification index was 54.9 (42.5 to 67.3), p < 0.0001. In patients with HFrEF and CAD following HF hospitalization, we found that NT-proBNP, BNP, TIMD4, FGF-23, GDF-15, PSP-D and SPON1, biomarkers broadly associated with inflammation and remodeling mechanistic pathways, were strong but indiscriminate predictors of a variety of individual CV events.
Cancer genomic profiling identified dihydropyrimidine dehydrogenase deficiency in bladder cancer promotes sensitivity to gemcitabine
Authors: Tsukahara Shigehiro , Shiota Masaki , Takamatsu Dai , Nagakawa Shohei , Matsumoto Takashi , Kiyokoba Ryo , Yagi Mikako , Setoyama Daiki , Noda Nozomi , Matsumoto Shinya , Hayashi Tetsutaro , Contreras-Sanz Alberto , Black Peter C. , Inokuchi Junichi , Kohashi Kenichi , Oda Yoshinao , Uchiumi Takeshi , Eto Masatoshi , Kang Dongchon 
Published: May 2022

AbstractChemotherapy is a standard therapy for muscle-invasive bladder cancer (MIBC). However, genomic alterations associated with chemotherapy sensitivity in MIBC have not been fully explored. This study aimed to investigate the genomic landscape of MIBC in association with the response to chemotherapy and to explore the biological role of genomic alterations. Genomic alterations in MIBC were sequenced by targeted exome sequencing of 409 genes. Gene expression in MIBC tissues was analyzed by western blotting, immunohistochemistry, and RNA microarray. Cellular sensitivity to gemcitabine and gemcitabine metabolite was examined in bladder cancer cells after modulation of candidate gene. Targeted exome sequencing in 20 cases with MIBC revealed various genomic alterations including pathogenic missense mutation of DPYD gene encoding dihydropyrimidine dehydrogenase (DPD). Conversely, high DPYD and DPD expression were associated with poor response to gemcitabine-containing chemotherapy among patients with MIBC, as well as gemcitabine resistance in bladder cancer cells. DPD suppression rendered cells sensitive to gemcitabine, while DPD overexpression made cells gemcitabine-resistant through reduced activity of the cytotoxic gemcitabine metabolite difluorodeoxycytidine diphosphate. This study revealed the novel role of DPD in gemcitabine metabolism. It has been suggested that DPYD genomic alterations and DPD expression are potential predictive biomarkers in gemcitabine treatment.
Boltzmann-Poisson-like approach to simulating the galactic halo response to satellite accretion
Authors: Aguilar-Argüello G. , Valenzuela O. , Trelles A. 
Published: May 2022

Context. Recent studies have reported the detection of the galactic stellar halo wake and dipole triggered by the Large Magellanic Cloud (LMC), mirroring the corresponding response from dark matter (DM). These studies open up the possibility of adding constraints on the global mass distribution of the Milky Way (MW), and even on the nature of DM itself, with current and upcoming stellar surveys reigniting the discussion on response modes in dynamical friction. However, the simulation of such features remains computationally challenging.
Aims. Using a continuous medium approach, we investigate the density and velocity response modes in simulations of Galactic-type DM halos accreting LMC-sized satellites, including the dependence on the halo density profile.
Methods. We used, for the first time in the context of galactic dynamics, a collisionless Boltzmann equation (CBE)+Poisson solver based on an existing method from the literature. We studied the dynamical density and velocity response of halos to sinking perturbers.
Results. We successfully captured both the local wake and the global over- and underdensity induced in the host halo. We also captured the velocity response. In line with previous studies, we find that the code can reproduce the core formation in the cuspy profile and the satellite core stalling. The angular power spectrum (APS) response is shown to be sensitive to each density profile. The cored Plummer density profile seems the most responsive, displaying a richness of modes. At the end of the simulation, the central halo acquires cylindrical rotation. When present, a stellar component is expected to behave in a similar fashion.
Conclusions. The CBE description makes it tenable to capture the response modes with a better handling of noise in comparison to traditional N-body simulations. Hence, given a certain noise level, BPM has a lower computational cost than N-body simulations, making it feasible to explore large parameter sets. We anticipate that stellar spheroids in the MW or external galaxies could show central cylindrical rotation if they underwent a massive accretion event. The code can be adjusted to include a variety of DM physics.
Steps towards equitable care: creating web pages to highlight diversity for Australia’s aged care and end of life care workforce
Authors: Rowley Georgia , Tieman Jennifer , Jones Kelly 
Published: May 2022

Background The impact of Australia’s diverse population on the aged care sector has been acknowledged, with the Royal Commission into Aged Care Quality and Safety findings providing evidence of the importance of population diversity for consumer-directed and person-centred care. Similarly, the Aged Care Quality Standards and Aged Care Diversity Framework acknowledge the diversity of Australia’s ageing population and potential implications for equitable access to care and the ensuing importance of culturally appropriate and culturally safe care. This paper reports on the development of informational web pages and utilisation findings for use by the aged care workforce supporting diverse populations. Methods Content was created for the End of Life Directions for Aged Care website, based on rapid review findings relating to barriers and limitations for people accessing equitable care in the aged care and palliative care sectors. Results Website pages containing embedded links to useful content and resources for health professionals and care workers who work with older diverse adults are shown to be well received among users. Conclusions As Australia’s future population will age with increasing diversity markers, with implications for aged care and palliative care service provision, workforce access to up-to-date, relevant and evidence-informed information on best practice non-clinical support for individuals from diverse backgrounds towards the end of life promotes a person-centred care approach. Access data shows that the website content is being utilised increasingly over time and suggests that it is filling a gap in comprehensive and accessible end of life resources that have been missing from the Australian aged care and palliative care workforce.
A theory of consciousness from a theoretical computer science perspective: Insights from the Conscious Turing Machine
Authors: Blum Lenore , Blum Manuel 
Published: May 2022

Significance
This paper provides evidence that a theoretical computer science (TCS) perspective can add to our understanding of consciousness by providing a simple framework for employing tools from computational complexity theory and machine learning. Just as the Turing machine is a simple model to define and explore computation, the Conscious Turing Machine (CTM) is a simple model to define and explore consciousness (and related concepts). The CTM is not a model of the brain or cognition, nor is it intended to be, but a simple substrate-independent computational model of (the admittedly complex concept of) consciousness. This paper is intended to introduce this approach, show its possibilities, and stimulate research in consciousness from a TCS perspective.
Influenza chimeric hemagglutinin structures in complex with broadly protective antibodies to the stem and trimer interface
Authors: Zhu Xueyong , Han Julianna , Sun Weina , Puente-Massaguer Eduard , Yu Wenli , Palese Peter , Krammer Florian , Ward Andrew B. , Wilson Ian A. 
Published: May 2022

Significance
Sequential vaccination with chimeric hemagglutinins (cHAs) that contain the same stem, but different head domains, can direct the antibody immune response to the conserved stem region. Structural information on cHAs is limited to one example containing a group 1 stem. Here, X-ray and electron microscopy structures revealed that cHAs cH4/3 and cH15/3, which contain a group 2 stem, with broadly protective stem antibody 31.a.83, have intact, native-like stem regions. Furthermore, the cHA head domains were in an open conformation, which exposes the conserved trimer interface region. Structure determination of cH15/3 HA with 31.a.83 and head interface antibody FluA-20 suggests that broadly protective antibodies could be elicited against both the conserved HA stem and the head interface.
An epitaxial perovskite as a compact neuristor: electrical self-oscillations in TbMnO3 thin films
Authors: Salverda M , Hamming-Green R P , Noheda B 
Published: May 2022

Abstract
Developing materials that can lead to compact versions of artificial neurons (neuristors) and synapses (memristors) is the main aspiration of the nascent neuromorphic materials research field. Oscillating circuits are interesting as neuristors, as they emulate the firing of action potentials. Here we present room-temperature self-oscillating devices fabricated from epitaxial thin films of semiconducting TbMnO3. We show that the negative differential resistance regime observed in these devices, orginates from transitions across the electronic band gap of the semiconductor. The intrinsic nature of the mechanism governing the oscillations gives rise to a high degree of control and repeatability. Obtaining such properties in an epitaxial perovskite oxide opens the way towards combining self-oscillating properties with those of other piezoelectric, ferroelectric, or magnetic perovskite oxides in order to achieve hybrid neuristor-memristor functionality in compact heterostructures.