bluuebunny/crossref_metadata_2025_split huggingface dataset:
Causes and management of persistent septal deviation after septoplasty
Authors: Lee Dong-Joo , Jo Hyunju , Kwon Ha-Nee , Park Ji-Hwan , Kim Sung-Dong , Cho Kyu-Sup 
Published: November 2022

AbstractSeptoplasty is one of the most common otolaryngological surgical procedures. The causes of persistent septal deviation after primary septoplasty vary. The purpose of this study was to identify factors associated with failure of primary septoplasty, operative techniques that correct residual septal deviation, and surgical outcomes. Seventy-four adults who underwent revision septoplasty to treat persistent septal deviations were enrolled. The level of hospital in which primary septoplasty was performed, type of septal deviation, septal portion exhibiting persistent deviation, and techniques used to correct the deviation were evaluated. Outcomes were measured subjectively using a visual analog scale (VAS), and objectively using acoustic rhinometry. The first septoplasties were usually performed in primary and secondary hospitals. C-shaped deviations were more common than S-shaped ones in both the anteroposterior and cephalocaudal dimensions. The most common region of persistent septal deviation was the caudal septum (44.6%), followed by multiple sites (20.3%). The corrective techniques included excision of the remnant deviated portion (70.3%), septal cartilage traction suturing (27.0%), spreader grafting (13.5%), and cross-suturing (6.8%). The VAS score improved significantly 6 months after surgery. The minimal cross-sectional area and nasal cavity volume of the convex side increased significantly after revision septoplasty. Patients who underwent septoplasty in primary and secondary hospitals were more likely to require revision septoplasty. The caudal septum was the most common site of persistent septal deviation. Careful preoperative evaluation of the caudal septal deviation and selection of an appropriate surgical technique may reduce the need for revision septoplasty.
Loss of participation among evacuees aged 20–37 years in the disaster cohort study after the Great East Japan Earthquake
Authors: Yamamoto Kana , Takita Morihito , Kami Masahiro , Tani Yuta , Yamamoto Chika , Zhao Tianchen , Ohira Tetsuya , Maeda Masaharu , Yasumura Seiji , Sakai Akira , Hosoya Mitsuaki , Okazaki Kanako , Yabe Hirooki , Tsubokura Masaharu , Shimabukuro Michio , Ohto Hitoshi , Kamiya Kenji 
Published: November 2022

AbstractThe present study aimed to clarify the characteristics of young evacuees who had missed the Comprehensive Health Check of the Fukushima Health Management Survey (FHMS) after the Great East Japan Earthquake in 2011. The FHMS has been conducted as a prospective cohort study to evaluate the health status of evacuees annually after the great earthquake in 2011. This study focused on the annual participation rate in the Comprehensive Health Check of evacuees aged between 20 and 37 years in 2011 who evacuated due to the Fukushima Daiichi Nuclear Power Plant accident. The characteristics of subjects who did not participate after the second survey year were identified with a multivariate logistic regression model. The participation rate was estimated at 26.6% (9720 among 36,502 residents) and 15.6% (5691 residents) in 2011 and 2012, respectively. The logistic regression model revealed the following characteristics at baseline as independent predictors of non-participation after the second year of the survey: age ≤ 24 years (adjusted odds ratio 2.11, 95% CI 1.84–2.42), 25–29 years of age (1.28, 1.13–1.45), men (1.52, 1.38–1.69), evacuation outside the municipality but within Fukushima prefecture (1.54, 1.40–1.70), evacuation outside the Fukushima prefecture (1.40, 1.21–1.63), anemia (1.23, 1.06–1.43), smoking habit (1.34, 1.21–1.48), and drinking habit (1.20, 1.09–1.32). A medical history of heart disease showed opposite odds ratios, which indicate the association with continuous participation (0.43, 0.26–0.72, respectively). We observed deteriorated participation in the prospective study of the Comprehensive Health Check of the FHMS among evacuees of a younger age group, men, those evacuated outside their municipalities, and those with history of anemia, smoking and drinking habits. Hence, the cohort study may have missed certain population groups with worse health behaviors. Thus, it is necessary to consider various measures to increase the participation rate in the disaster cohort study to understand the long-term health effects of disasters on younger residents in evacuation zones.
A qualitative study on the experience of stigma for Chinese parents of children with autism spectrum disorder
Authors: Ng Catalina Sau Man , Ng Sally Sui Ling 
Published: November 2022

AbstractExperiencing stigma related to having a child with autism spectrum disorder (ASD) can be difficult and is detrimental to parent well-being. Since the research on stigmatized experiences among parents of children with ASD in non-Western communities is limited, this qualitative study examined the experiences, reactions and impacts of stigma on parents of children with ASD in Hong Kong. In-depth interviews were conducted with 54 Chinese parents/caregivers of children with ASD aged between 35 and 73 years old. Data were analyzed using an inductive approach. The participants reported stigma which stemmed from negative labelling of their children by schools and healthcare professionals, bullying by peers, stereotypes of ASD and stigma linked to autistic children’s behavior in the community. The reactions of participants towards stigmatization were classified into internalizing reactions including apologizing, ignoring and concealing ASD and externalizing reactions such as fighting back. The participants also reported impacts of stigma on both personal and emotional levels. The results point to the urgent need for the government to allocate resources and make concerted efforts to reduce stigma by educating the community to foster more positive attitudes towards individuals with ASD and offer support and counselling services to parents.
TNF-alpha inhibitors biosimilar use in France: a nationwide population-based study using the French National Health Data System
Authors: Jourdain Hugo , Hoisnard Léa , Sbidian Emilie , Zureik Mahmoud 
Published: November 2022

AbstractTNF-alpha inhibitors have revolutionized the therapeutic care in chronic inflammatory diseases. Several biosimilar products were commercialized at their patent expiry, substantially decreasing the cost of treatment. This longitudinal descriptive study aimed at assessing infliximab, etanercept and adalimumab biosimilar penetration rates using data of the French National Health Data System. A total of 207,118 new or prevalent users from the date of first biosimilar commercialization in France (respectively January 2015, May 2016 and October 2018) were included in the study and followed until September 30, 2021. Biosimilars represented respectively 78%, 46% and 53% of the overall initiations, and 94%, 66% and 60% last year’s initiations. A total of 46%, 19% and 17% of originator product prevalent users switched for a biosimilar during the follow-up. Biosimilar penetration rate was much higher for infliximab than for its counterparts, due to its hospital delivery modality. Biosimilar initiation and originator-to-biosimilar switch tended to be observed more in rheumatology than in the other specialties. Biosimilar use was mostly consistent across patient socio-demographic characteristics. Biosimilar initiation rate increased rapidly from their market arrival and originator-to-biosimilar switch rate remained moderate, highlighting the need and usefulness of political action and biosimilar use tracking.
A genotyping by sequencing approach can disclose Apis mellifera population genomic information contained in honey environmental DNA
Authors: Bovo Samuele , Utzeri Valerio Joe , Ribani Anisa , Taurisano Valeria , Schiavo Giuseppina , Fontanesi Luca 
Published: November 2022

AbstractAwareness has been raised over the last years on the genetic integrity of autochthonous honey bee subspecies. Genomic tools available in Apis mellifera can make it possible to measure this information by targeting individual honey bee DNA. Honey contains DNA traces from all organisms that contributed or were involved in its production steps, including the honey bees of the colony. In this study, we designed and tested a genotyping by sequencing (GBS) assay to analyse single nucleotide polymorphisms (SNPs) of A. mellifera nuclear genome using environmental DNA extracted from honey. A total of 121 SNPs (97 SNPs informative for honey bee subspecies identification and 24 SNPs associated with relevant traits of the colonies) were used in the assay to genotype honey DNA, which derives from thousands of honey bees. Results were integrated with information derived from previous studies and whole genome resequencing datasets. This GBS method is highly reliable in estimating honey bee SNP allele frequencies of the whole colony from which the honey derived. This assay can be used to identify the honey bee subspecies of the colony that produced the honey and, in turn, to authenticate the entomological origin of the honey.
Crystal structure of semi-synthetic obelin-v after calcium induced bioluminescence implies coelenteramine as the main reaction product
Authors: Natashin Pavel V. , Eremeeva Elena V. , Shevtsov Mikhail B. , Kovaleva Margarita I. , Bukhdruker Sergey S. , Dmitrieva Daria A. , Gulnov Dmitry V. , Nemtseva Elena V. , Gordeliy Valentin I. , Mishin Alexey V. , Borshchevskiy Valentin I. , Vysotski Eugene S. 
Published: November 2022

AbstractCoelenterazine-v (CTZ-v), a synthetic vinylene-bridged π-extended derivative, is able to significantly alter bioluminescence spectra of different CTZ-dependent luciferases and photoproteins by shifting them towards longer wavelengths. However, Ca2+-regulated photoproteins activated with CTZ-v display very low bioluminescence activities that hampers its usage as a substrate of photoprotein bioluminescence. Here, we report the crystal structure of semi-synthetic Ca2+-discharged obelin-v bound with the reaction product determined at 2.1 Å resolution. Comparison of the crystal structure of Ca2+-discharged obelin-v with those of other obelins before and after bioluminescence reaction reveals no considerable changes in the overall structure. However, the drastic changes in CTZ-binding cavity are observed owing to the completely different reaction product, coelenteramine-v (CTM-v). Since CTM-v is certainly the main product of obelin-v bioluminescence and is considered to be a product of the “dark” pathway of dioxetanone intermediate decomposition, it explains the low bioluminescence activity of obelin and apparently of other photoproteins with CTZ-v.
Association between fractional amplitude of low-frequency fluctuation (fALFF) and facial emotion recognition ability in first-episode schizophrenia patients: a fMRI study
Authors: Kuang Qijie , Zhou Sumiao , Li Haijing , Mi Lin , Zheng Yingjun , She Shenglin 
Published: November 2022

AbstractIt was still unclear that the correlation between the resting-state intrinsic activity in brain regions and facial emotion recognition (FER) ability in patients with first-episode schizophrenia (FSZ). Our aim was to analyse the correlation between the fractional amplitude of low-frequency fluctuation (fALFF) and FER ability in FSZ patients. A total of 28 patients with FSZ and 33 healthy controls (HCs) completed visual search tasks for FER ability. Regions of interest (ROIs) related to facial emotion were obtained from a previous meta-analysis. Pearson correlation analysis was performed to understand the correlation between fALFF and FER ability. Our results indicated that the patients performed worse than the HCs in the accuracy performances of happy FER and fearful FER. The previous meta-analysis results showed that the brain regions related to FER included the bilateral amygdala (AMY)/hippocampus (HIP), right fusiform gyrus (FFG), and right supplementary motor area (SMA). Partial correlation analysis showed that the fALFF of the right FFG was associated with high-load fearful FER accuracy (r = − 0.60, p = 0.004). Our study indicated that FER ability is correlated with resting-state intrinsic activity in brain regions related to facial emotion, which may provide a reference for the study of FER deficiency in schizophrenia.
Trifloxystrobin blocks the growth of Theileria parasites and is a promising drug to treat Buparvaquone resistance
Authors: Villares Marie , Lourenço Nelly , Berthelet Jeremy , Lamotte Suzanne , Regad Leslie , Medjkane Souhila , Prina Eric , Rodrigues-Lima Fernando , Späth Gerald F. , Weitzman Jonathan B. 
Published: November 2022

AbstractTheileria parasites are responsible for devastating cattle diseases, causing major economic losses across Africa and Asia. Theileria spp. stand apart from other apicomplexa parasites by their ability to transform host leukocytes into immortalized, hyperproliferating, invasive cells that rapidly kill infected animals. The emergence of resistance to the theilericidal drug Buparvaquone raises the need for new anti-Theileria drugs. We developed a microscopy-based screen to reposition drugs from the open-access Medicines for Malaria Venture (MMV) Pathogen Box. We show that Trifloxystrobin (MMV688754) selectively kills lymphocytes or macrophages infected with Theileria annulata or Theileria parva parasites. Trifloxystrobin treatment reduced parasite load in vitro as effectively as Buparvaquone, with similar effects on host gene expression, cell proliferation and cell cycle. Trifloxystrobin also inhibited parasite differentiation to merozoites (merogony). Trifloxystrobin inhibition of parasite survival is independent of the parasite TaPin1 prolyl isomerase pathway. Furthermore, modeling studies predicted that Trifloxystrobin and Buparvaquone could interact distinctly with parasite Cytochrome B and we show that Trifloxystrobin was still effective against Buparvaquone-resistant cells harboring TaCytB mutations. Our study suggests that Trifloxystrobin could provide an effective alternative to Buparvaquone treatment and represents a promising candidate for future drug development against Theileria spp.
Pembrolizumab-induced acute exacerbation of hepatitis D
Authors: Fichtl Anna , Beck Annika , Seufferlein Thomas , Zizer Eugen 
Published: November 2022

AbstractA 55-year-old man was treated with combined immunochemotherapy (pembrolizumab, carboplatin and pemetrexed) because of non-small cell lung cancer (NSCLC). In addition, the patient had a medical history of chronic hepatitis B/D virus infection and cystic echinococosis. The viral hepatitis co-infection was treated with pegylated interferon (IFN)-alpha and tenofovir in the past (non-response after treatment), followed by maintenance therapy with tenofovir. Since the echinococosis was inactive, there was no need for specific treatment. The therapy for NSCLC had to be stopped after three weeks due to rising liver enzymes. HDV-RNA could be detected as high as 107 GE/mL in the serum, HBV-DNA was not detected. A liver biopsy was performed. Histological analysis showed a chronic and partly active hepatitis, but its aetiology remained unclear. Because of the stable viral load after the first administration of pembrolizumab, an autoimmune-induced liver injury was suspected. Thus, a prednisolone-treatment was initiated. Yet, the liver enzyme levels did not decline, so bulevirtide (2 mg/d s.c.) was added to the ongoing antiviral treatment with tenofovir. This new treatment combination led to a restitution of the elevated enzymes; HDV-RNA was below detection limit. Finally, the therapy for NSCLC could be continued. The antiviral therapy could improve the patient´s prognosis significantly. To our knowledge, this is the first reported case of a pembrolizumab-induced exacerbation of hepatitis D and a successful management by application of bulevirtide in the context of cancer.
Comparison of High Power Pain Threshold Ultrasound and Ischemic
Compression Techniques for the Treatment of Latent Myofascial Trigger Points: A
Randomized Controlled Study
Authors: Pala Gamze Gülsün , Mutlu Ebru Kaya , Taşkıran Hanifegül 
Published: November 2022

Abstract
Objective Myofascial trigger points (MTrPs) have been defined as discrete
and hyperirritable areas located within a taut band of skeletal muscle or
fascia, which when compressed produce pain, tenderness, dysfunction and
autonomic phenomena. The treatment techniques aimed to return the fiber groups
to their optimum length and end plates to their optimum function. Ischemic
Compression (IC) and of High Power Pain Threshold Ultrasound (HPPT-US) are among
the treatment techniques used for MTrPs. The aim of the current study is to
compare the efficacy of IC and HTTP-US which was applied in different ways on
MTrPs treatment.
Patients and Methods This is a randomized prospective study conducted with
153 participants have at least three latent trigger points. Participants
received HPPT-US technique in which the intensity is kept constant at the pain
level, HPPT-US technique in which the intensity is kept constant at half the
pain level or IC. Outcome measures were the Visual Analog Scale, Beck Depression
Inventory, Neck Pain and Disability Scale, number of deactivated MTrPs and Pain
Pressure Threshold (PPT).
Results Pain, psychological status and disability improved in each group;
there was no significant difference between the groups (p>0.05). PPT
increased in each group; a significant difference was found between the groups
(p<0.05). IC was slightly more effective than HPPT-US.
Conclusion Our results have shown that HPPT-US which was applied in
different ways and IC were effective therapies for latent trigger points.
Outcomes of Percutaneous Peritoneal Dialysis Catheters Insertion by Interventional Radiologists: A Single-Institution Experience
Authors: Alhussaini Khadijah , Abulqasim Shaima , Al-Sharydah Abdulaziz Mohammad , Elhassan Elwaleed , Arabi Mohammad 
Published: November 2022

Abstract
Objectives This article evaluates the short- and long-term outcomes of percutaneous peritoneal dialysis (PD) catheters inserted by interventional radiology service and analyzes the factors that affect the sustainability of patent and functional PD catheters.
Materials and Methods Retrospective single-institution study between April 2015 and February 2021. A total of 131 patients (75 males) were enrolled with mean age of 50 ± 19.6 years with an average body mass index (BMI) of 28 ± 7 kg/m2. Technical and clinical success were evaluated. Catheter-related complications were classified into mechanical and nonmechanical categories, including infectious complications. Indications for removal were analyzed.
Results Technical and clinical success were 100%. The average dwelling time for the entire cohort was 497.5 ± 462.3 days. Forty-six patients (35%) were on PD at the last follow-up with an average dwelling time of 492 days. PD-related complications were reported in 79/131 (60.3%) patients, including peritonitis (40.46%; 53/131), followed by malposition/migration (12.21%; 16/131), tunnel/exit site infection (10.69%; 14/131), and dysfunction (12.21%; 16/131). The incidence of peritonitis within 30 days postinsertion was 9.43% (5/53). The average interval between insertion and migration was 100.5 ± 144.8 days (95% confidence interval, 6.9–14.4). There was a trend for a higher rate of malposition/migration in patients with higher BMI (p = 0.0561). Causes for PD catheters removal were: (1) infection-related (24.4%; 32/131), (2) renal transplant recipients (16%; 21/131), (3) mechanical complications (13.7%; 18/131), and (4) patient's preference (7.6%; 10/131).
Conclusion Percutaneous PD catheter placement by interventional radiologists provides acceptable long-term outcomes and complication rates that meet the recommended standards.
A scalable cryogenic LED module for selectively illuminating kinetic inductance detector arrays
Authors: Shroyer J. E. , Nelson M. , Walters L. , Johnson B. R. 
Published: November 2022

We present the design and measured performance of a light emitting diode (LED) module for spatially mapping kinetic inductance detector (KID) arrays in the laboratory. Our novel approach uses a multiplexing scheme that only requires seven wires to control 480 red LEDs, and the number of LEDs can be scaled up without adding any additional wires. This multiplexing approach relies on active surface mount components that can operate at cryogenic temperatures down to 10 K. Cryogenic tests in liquid nitrogen and inside our cryostat demonstrate that the multiplexer circuit works at 77 and 10 K, respectively. The LED module presented here is tailored for our millimeter-wave detector modules, but the approach could be adapted for use with other KID-based detector systems.
Outer layer scintillating fiber for low-energy β-ray detection
Authors: Toyama Sho , Matsuyama Shigeo , Miwa Misako , Akari Masashi , Fujita Katsuhiro 
Published: November 2022

Standard plastic scintillating fiber cannot detect low-energy β-rays as the cladding prevents them from reaching the fiber core. We developed an outer-layer scintillating (OLS) fiber with a plastic scintillator on the outermost layer for low-energy β-ray detection. The concept of fiber construction is presented. The fundamental optical properties of the OLS fiber, such as the emission spectrum, attenuation length, and scintillation decay time, were evaluated. Here, Ni-63 with a maximum energy of 67.0 keV was used as a low-energy β-emitting nuclide. Simulation studies on the interaction between low-energy electrons emitted from Ni-63 and a single fiber were performed prior to actual measurements. The data showed that Ni-63 can be measured using silicon photomultiplier photosensors in a coincidence mode. The OLS fiber was effective for low-energy β-ray detection.
Development of a 50-A heaterless hollow cathode for electric thrusters
Authors: Payman Adele R. , Goebel Dan M. 
Published: November 2022

Hollow cathodes in electric thrusters normally use an external heater to raise the thermionic electron emitter to emission temperatures. These heaters are a potential single-point failure in the thruster and add a separate power supply to the power processing unit. Heaterless hollow cathodes are attractive for their compact size and potential higher reliability but have only been reliably demonstrated to date in small hollow cathodes capable of discharge currents below around 5 A. A new heaterless LaB6 hollow cathode has been developed that is capable of discharge currents from 5 to 50 A. The cathode configuration extends the gas feed tube at cathode potential part way into the emitting insert region of the cathode. A high-voltage Paschen discharge is struck from the tube to the keeper that heats the tube tip, which then efficiently heats the insert by radiation. This configuration eliminates the arcing observed in prior large heaterless designs that coupled the high-voltage Paschen discharge to the orifice plate or the insert itself. Discharge current–voltage characteristics show that the presence of the tube does not significantly perturb the insert-region plasma. Startup uses a simple 3 min ignition procedure, and voltage traces of the keeper discharge reveal that much of the present tube-radiator’s 100-to-150 W heating power comes from an intermediate thermionic discharge sustained by the tube during the transition between the Paschen discharge and LaB6 insert thermionic regime. This novel heating mechanism enables an unprecedented class of higher-current heaterless hollow cathodes for the next generation of high-power electric propulsion systems.