bluuebunny/crossref_metadata_2025_split huggingface dataset:
INVESTIGATING MEDIATORS OF SYSTEMIC MITOCHONDRIAL BIOENERGETICS IN COGNITIVE IMPAIRMENT AND ALZHEIMER’S DISEASE
Authors: Mahapatra Gargi , Bergstrom Jaclyn , Pinto Antonio Michel , Diedrich Jolene , Craft Suzanne , Molina Anthony 
Published: January 2025

Abstract
We previously showed peripheral blood mononuclear cell (PBMC) and platelet mitochondrial bioenergetic capacities are lower in older adults with Alzheimer’s disease (AD), with notable changes in fatty acid oxidation (FAO)-mediated respiration. The metabolic pathways underlying mitochondrial functional differences remain un-identified. This study investigated lipid metabolites that are differently expressed across different stages of cognitive impairment (CI). Targeted lipidomics analyzed 51 fatty acids (FAs) in PBMCs and platelets of older adults with normal cognition (NC), mild cognitive impairment (MCI), and AD dementia (DEM). 10 FAs were selected in each cell type based on significant concentration differences between different cognitive groups. In PBMCs, 9 FAs exhibited higher concentrations in MCIs than NC and DEM, with significantly lower concentration in DEM than MCI, while 1 FA exhibited progressively declining concentrations from NC to MCI to DEM. Significant positive correlations were observed between FA concentrations and FAO and maximal mitochondrial respiration (Max). In platelets, 7 FAs showed progressively declining concentrations from NC to MCI to DEM, and significant positive correlations with FAO and Max, while 3 FAs showed progressively increasing concentrations with cognitive impairment, and significant negative correlations with FAO and Max. Significant negative correlations were also observed with mPACC5 cognitive assessment scores and hippocampal volumes. Pathway analyses identified FA biosynthesis, alpha-linolenic acid, and alpha-linoleic acid metabolism as involved pathways differently impacted across cognitive groups. These findings emphasize the importance of FAs and related metabolic pathways in systemic bioenergetic decline in CI, and may facilitate development of preventative, diagnostic, and therapeutic approaches in AD.
CAN CHATGPT PERFORM GERIATRIC KNOWLEDGE TESTS AS WELL AS MEDICAL STUDENTS, RESIDENTS, AND GERIATRICS FELLOWS?
Authors: Cheng Huai 
Published: January 2025

Abstract
ChatGP was released to the public in November of 2022 and immediately emerged as a quick information resource and application to medical education. ChatGPT passed USMLE step 1, 2 and 3. This study was to examine whether ChatGPT can perform well on 18 published validated geriatric knowledge questions compared to medical students, residents, and geriatrics medicine fellows. These 18 geriatric knowledge questions with 8 True or False questions and 10 clinical vignettes were developed to assess geriatric knowledge for medical students, residents, and geriatrics medicine fellows. In this study, ChatGPT was treated as a human or study participant and prompted to answer these 18 questions four times from April to November of 2023. Outputs from ChatGPT were collected for analysis. The mean scores of 18 questions were compared between ChatGPT and the trainees including medical students, residents, and geriatrics medicine fellows. It was found that the mean score (14.25, n=4 prompts) from ChatGPT was higher than the scores from medical students and similar to residents, however lower than geriatrics medicine fellows. Additionally, half of output from ChatGPT gave good rational for their response to the questions. This indicated ChatGPT performed reasonably well on 18 validated geriatric knowledge questions. ChatGPT could be used as a supplemental resource in geriatrics for trainees at their early stage of training and perhaps for lay persons as well.
THE EXPERIENCE OF SOCIAL WORKERS IN BIG DATA–BASED CARE SERVICES ON PREVENTING SOCIAL ISOLATION FOR OLDER ADULTS
Authors: Kim Haklyoung , Hwang Boram , Kang Sungwan , Choi Seongsu , Mun Kyoungmi , Lee Yeong Ju 
Published: January 2025

Abstract
In response to the increasing occurrence of social isolation among older adults in South Korea, local governments and ICT companies are collaborating to introduce various intelligent care initiatives based on big data, including AI care calls, AI speakers, and activity detection sensors. This study investigates the experiences of social workers providing on-site intelligent care services to older individuals living alone to prevent social isolation. Five focus group interviews involving 15 welfare officials and social workers were conducted. The findings are as follows. Firstly, they recognized biases regarding intelligent technology, such as concerns about privacy infringement, as barriers to identifying high-risk groups and accepting services. Secondly, challenging living environments with limited internet access and low digital literacy were acknowledged as obstacles hindering the sustained use of intelligent care services. Thirdly, the presence of personnel capable of providing education and support for smart device usage was deemed essential for the continued utilization of services. Fourthly, it was acknowledged that additional personnel and support beyond smart devices are necessary for groups with impaired vision, hearing, or mobility. Lastly, the involvement of social workers with a deep understanding of high-risk groups, from planning to evaluation of service models, was recognized as essential for enhancing the effectiveness and efficiency of services. Based on these findings, this study suggests practical and policy implications regarding intelligent living environments, digital literacy, ethics of artificial intelligence, caregiver training, and the involvement of social workers.
A COMPARISON OF HEARING AID USERS AND NONUSERS AMONG PERSONS LIVING WITH COGNITIVE IMPAIRMENT
Authors: Kim Jayeong , Hwang Yeji 
Published: January 2025

Abstract

Hearing impairment is common in older adults, including those with cognitive impairment. While hearing aids can alleviate the challenges posed by hearing impairment, less is known about the usage of hearing aids among individuals living with cognitive impairment. Therefore, this study was conducted with two main

objectives
To identify the prevalence of hearing aid usage among individuals with both cognitive and hearing impairment, and to examine the characteristics of those utilizing hearing aids. Secondary data analyses were conducted using 2020 National Survey of Older Koreans, which includes a nationally representative sample of community-residing older adults. This study included older adults aged 65 years and older who had both cognitive and hearing impairment (n=755). Chi-square tests and independent t-tests were employed to compare the characteristics of hearing aid users to non-users. Among those experiencing both cognitive and hearing impairment, only 32.8% used hearing aids. Individuals using hearing aids were older (t=-4.69, p&lt;.001) and had a higher number of chronic diseases (t=-2.10, p=.036) and medications (t=-2.57, p=.010) compared to non-users. Furthermore, hearing aid users exhibited poorer cognition (t=4.17, p&lt;.001), reported greater depressive symptoms (t=-3.7247, p&lt;.001), and participated less in leisure activities (Chi2=11.73, p&lt;.001). Given that only a small portion of individuals facing hearing difficulties utilized hearing aids, there is a need for greater access to these devices to enhance overall quality of life. Additionally, this study revealed that individuals using hearing aids had poorer health conditions compared to non-users. Future research should consider objectively measuring hearing impairment to better examine this relationship.
PHYSICAL ACTIVITY AND SEDENTARY BEHAVIOR IN RESIDENTS OF ASSISTED LIVING: A PILOT LONGITUDINAL STUDY
Authors: Son Jung Yoen , Tucker She’Lon , Vos Carol , Larson Janet 
Published: January 2025

Abstract
Low levels of physical activity (PA) and high sedentary behavior (SB) place older assisted living (AL) residents at risk for functional decline and premature transfer to a higher level of care. This study aimed to examine the feasibility and acceptability of conducting a longitudinal study using two objective measures of PA and SB. We recruited participants from four AL facilities in Michigan. Participants wore two devices (ActiGraph at the wrist and ActivPal on the anterior thigh) for seven consecutive days twice, once at baseline and again six months later, and completed questionnaires. We evaluated recruitment, retention, and compliance with and acceptability of wearing devices, and conducted a longitudinal multilevel model to estimate preliminary changes in PA and SB over 6 months. Forty-two people volunteered, 19% were excluded with a low Mini-Cog score, 62% completed baseline (77% female; mean age=80.1), and 60% completed 6 months data collection. Most participants were willing to perform two measures of PA and SB and generally found the procedures to be acceptable. Over 6 months, moderate to vigorous PA significantly declined by 8 min/day (p=0.02), light PA declined by 18 min/day (p=0.13), and SB increased by 15 min/day (p=0.48). In conclusion, the results support the feasibility and acceptability of this research protocol. Participants had a small decline in PA over a six-month period of time, which was not clinically meaningful but could become significant if the trend continued.
RECRUITMENT STRATEGIES IN LONG-TERM CARE: NEW AND NOVEL APPROACHES
Authors: Maxwell Cathy , Tate Judith , Juckett Lisa , Colopietro Kelley , Kilpatrick Abbey , Mion Lorraine , Sarkar Nilanjan 
Published: January 2025

Abstract

Older adults residing in long term care (LTC) can benefit from social and behavioral research to improve health outcomes and promote evidence-based practice; however, recruitment is often difficult and time/cost-intensive. Systematic reviews of literature report recruitment barriers, as well as specific recruitment strategies. This presentation extends this work by reporting on new outreach endeavors within two state-based regions with over 300 LTCs. Our work is based on three longitudinal studies in LTC facilities to promote engineering and technology-based interventions that address apathy and loneliness in LTC residents. Relationship-building is the core of successful recruitment with establishment of trust and altruistic outreach. Our strategies include: 1) utilization of personnel with longstanding presence in the community and associated organizations (e.g., Alzheimer’s Association), 2) outreach opportunities to regional, state-based health care professional organizations, 3) repeated phone contacts to gauge interest, 4) provision of health screenings for residents (e.g., blood pressure, fall risk assessment), and 5) educational and enjoyable activities for residents (i.e., games, health-related topics [medications, nutrition, mind/body health, safety]). Research opportunities include studies using socially-assistive robots to address apathy among older adults with mild to moderate cognitive impairment, and augmented reality/avatar-based interventions to address loneliness among LTC residents. Our strategies established trust and promoted relationship-building between local and regional LTC facilities and the specific universities, resulting in successful recruitment of 17 (45%) out of 37 LTCs who responded to initial contact.

Conclusion
Successful recruitment in LTC requires multiple strategies. Trust and relationship-building promote reciprocity that can benefit both LTC facilities and universities.
SENSE OF AESTHETICS AMONG OLDER ADULTS NEW TO LONG-TERM CARE SERVICES AND SUPPORTS
Authors: Weiss Charlotte , Hirschman Karen , Naylor Mary 
Published: January 2025

Abstract
Engagement in aesthetic experiences and activities can contribute to older adults’ quality of life and social connection. Few studies explore older adults’ sense of aesthetics (the extent to which one obtains pleasure from sensory awareness and appreciation of beauty) and how this information may be useful in supporting older adults during transitions to long-term services and supports (LTSS; in home, assisted living, or nursing home). We conducted a secondary analysis of interviews with older adults new to LTSS (R01AG025524) to examine the factors associated with Sense of Aesthetics (SOA) [a Dementia Quality of Life subscale]. A total of 376 LTSS recipients had complete data. The average score of the SOA was 3.44 (SD: 0.98, range= 1-5, median=4; higher scores indicate a greater sense of aesthetics. Using multivariable linear regression, we controlled for the influence of important health-related quality of life covariates (e.g., LTSS setting, sex, age, education, number of comorbidities, sensory impairment [vision/hearing], cognitive status). Older adults with greater positive interaction with social support (p&gt;0.001) and a greater spiritual/religious disposition (p=0.004) had higher SOA. Older adults receiving LTSS in the nursing home had lower SOA compared to those in the home (p=0.029) and no difference between those receiving LTSS in home vs assisted living (p=0.49). The findings highlight the opportunity for LTSS intradisciplinary teams to consider the value that older adults assign to aesthetics and increase access to aesthetic experiences, especially within the nursing home setting. Implications for innovative ways to increase older adults’ sense of aesthetics will be discussed.
“WE ARE SYMBIOTIC”: THE IMPACT OF MULTIPLE CHRONIC CONDITIONS ON RELATIONSHIP DYNAMICS AMONG OLDER COUPLES
Authors: Eagle Angelica , Polenick Courtney 
Published: January 2025

Abstract
Despite the growing recognition of the impact of multiple chronic conditions (MCC) on individuals’ lives and relationships, there is limited understanding about the effects on spousal relationships when both spouses live with MCC. This qualitative study evaluated how older couples living with MCC perceive the impact of their conditions on their relationship. A total of 56 wives (M = 66.84 years, SD = 9.73) and husbands (M = 68.16 years, SD = 10.69), who both reported having two or more chronic conditions, completed separate semi-structured interviews that included open-ended questions about the effect of their conditions on their relationship. We separately evaluated couples that included a partner living with early-stage dementia (n = 15) and couples not living with dementia (n = 41) to assess whether the presence of dementia affects couples with MCC differently due to distinct care needs and communication challenges. The data were coded using qualitative content analysis to develop major themes. Themes for the relationship impacts of MCC among couples not living with dementia included: 1) adapting daily routines around functional limitations; 2) changes in emotional and physical intimacy; 3) changes in shared activities; and 4) stronger relationship impact on one partner. Themes for couples living with dementia included: 1) changes in emotional and physical intimacy; 2) stronger relationship impact on spouses of people living with dementia; and 3) increased time spent together. These findings identify potential targets for dyadic interventions to improve relationship functioning and quality among older couples living with MCC.
AN INVESTIGATION OF CDSMP OUTCOMES FOR PARTICIPANTS ENROLLING WITH DIFFERENT LEVELS OF NEED
Authors: Teply Abby , McKibbin Christine , Clapp Joshua , Carling Stacy , Goodwin Laurance , Carrico Catherine , Dabrowski Barbara , Punke Elizabeth 
Published: January 2025

Abstract
The Self-Management Resource Center’s evidence-based Chronic Disease Self-Management Program (CDSMP) empowers people to actively engage in their own care through a variety of evidence-based solutions. CDSMP strategies and foci align with the Age-Friendly framework - an evidence-based approach to guide health care with older adults that emphasizes 4Ms: “What Matters,” “Medication,” “Mentation,” and “Mobility.” In prior analysis of CDSMP baseline data, participants were represented by two distinct latent profiles based on age-friendly measures: individuals needing support (“NS”) and those who were coping well (“CW”). The purpose of this study was to examine differences in CDSMP outcomes among the participant profiles. Those completing baseline and follow-up assessments (n = 147) were included. Participants were predominantly White (n = 139; 94.6%) females (n = 18; 80.3%) with a mean age of 75.21 (SD = 18.83). Repeated measures ANOVAs revealed significant interactions between CW (n = 42) and NS (n = 105) groups from pre- to post-intervention. Relative to those in the CW group, those in the NS group had greater improvement on measures of interference with daily activities, F(1,144) = 5.15, p =.03, and self-efficacy, F(1,136) = 7.39, p =.01. Despite greater improvement, those in the NS profile still had greater interference with daily activities (M = 1.94, SD = 1.00) than those in the CW group (M = 1.19, SD = 1.08) at post-intervention, t(144) = 1.99, p =.05. Additional strategies may be needed to further improve outcomes for those belonging to the Age-Friendly, “needs support” profile.
APPLYING THE AGE-FRIENDLY 4MS FRAMEWORK TO IDENTIFY NEEDS OF INDIVIDUALS ENROLLED IN CDSMP
Authors: Teply Abby , McKibbin Christine , Clapp Joshua , Carling Stacy , Schenck Sabine , Carrico Catherine , Dabrowski Barbara , Punke Elizabeth 
Published: January 2025

Abstract
The Age-Friendly framework is an evidence-based approach to guide health care with older adults that emphasizes 4Ms: “What Matters,” “Medication,” “Mentation,” and “Mobility.” The Self-Management Resource Center’s evidence-based Chronic Disease Self-Management Program (CDSMP) aligns with this framework. Therefore, this study applied the 4Ms to identify needs of participants from CDSMP. Participants (n = 147) were predominantly White (n = 139; 94.6%) females (n = 18; 80.3%) with a mean age of 75.21 (SD = 18.83). The sample included caregivers/supporters (n = 68; 45.3%) and individuals with chronic illnesses (n = 79; 53.7%). Participants completed pre-post measures consistent with the 4Ms (e.g., provider communication, medication adherence, depressive symptoms, and exercise). A latent profile analysis was conducted to extract unobserved subgroups identified by common profiles of response at baseline. Indices of model fit suggested a two-profile model was appropriate. Profile 1 (labeled “Needs Support”) was characterized by poor medication adherence and mild depressive symptoms. High medication adherence and minimal depressive symptoms, in contrast, distinguished profile 2 (labeled “Coping Well”). T-tests revealed a significant difference between profiles on frontier and remote area (FAR) ratings, t(91.999) = -2.107, p =.038. On average, those in profile 1 lived in areas with higher FAR ratings (M = 1.10, SD = 1.24), suggesting greater remoteness, compared to those in profile 2 (M =.68, SD =.99). No differences were found on age, gender, education, etc. Rural living may complicate self-management. Additional research is needed to understand the implication of profile membership for program outcomes.
EXPLORING STRESSORS AND SELF-MANAGEMENT BEHAVIORS IN RURAL AGING AFRICAN AMERICANS WITH DIABETES: A PILOT STUDY
Authors: Harvey Idethia Shevon , Nittinger Sophia , Harris Maude , Wiggins Arika , Mkuu Rahma 
Published: January 2025

Abstract

Background
Rural African Americans with diabetes encounter unique challenges related to managing their condition, including diabetes-specific distress, financial stress, and interpersonal stressors. This study investigated the associations between these stressors and self-management behaviors in a small population sample.

Methods
Fifteen rural African American adults (mean age = 66.08 yrs.; SD = + 6.16) with diabetes participated in this cross-sectional study. Participants completed validated measures, including the Summary of Diabetes Self-Care Activity (SDSCA), Center for Epidemiologic Studies Depression Scale (CES-D), Perceived Stress Scale (PSS), Partner Strain, Parental Stress Scale, Diabetes Distress, Everyday Discrimination, and Cost-FACIT. Descriptive statistics and correlational analyses examined the relationships between stressors and self-management behaviors.

Results
Participants reported moderate levels of financial, relational, and perceived stress, and diabetes distress. Higher levels of financial stress were associated with poorer diabetes self-care activities (r = -0.628, p &lt; 0.05). Emotional burden (r = 0.804, p &lt; 0.01) and interpersonal distress (r = 0.600, p &lt; 0.05) are significantly correlated with perceived stress. Financial stress is significantly associated with everyday discrimination (r = 0.508, p &lt; 0.05).

Conclusion
Despite the small sample size, our findings highlight the intricate interplay between diabetes distress, financial stress, relationship stress, and self-management behaviors among rural African Americans with diabetes. Tailored interventions addressing these stressors and promoting effective coping strategies may be crucial in improving diabetes management outcomes in this population. Further research with larger samples is warranted to confirm these findings and inform targeted interventions for better diabetes care in rural African American communities.
HEALTH CARE PROVIDER PERSPECTIVES ON MENTAL HEALTH CARE WITHIN CHRONIC CARE MANAGEMENT: A RURAL STUDY
Authors: Punke Elizabeth , Wall Lucas , Dabrowski Barbara , Teply Abby , Richardson Katy , Carrico Catherine , McKibbin Christine 
Published: January 2025

Abstract
Approximately 59% of older adult Medicare beneficiaries experience two or more chronic conditions. This rate is even higher among those dually-enrolled in Medicare and Medicaid (i.e., 77%; Boersma et al. 2021). In 2015, the Centers for Medicare and Medicaid Services introduced Chronic Care Management (CCM), a value-based care program, to provide reimbursement to practices for care coordination services that support the management of patients with multimorbidity. Importantly, physical and mental health conditions are often interrelated; however, providers often struggle to adequately treat mental health needs in the context of physical illness (Lattie et al., 2020). The purpose of this study was to examine healthcare providers’ perspectives on serving individuals with mental health diagnoses enrolled in CCM within primary care practices. Investigators developed an interview for this qualitative study. Employees of six practices that have implemented CCM participated. Participants completed sociodemographic, professional, and practice history measures, and a qualitative interview. Participants (n = 13) were predominantly White, cisgender females (n = 12; 92%) and represented care coordinators, primary care providers, allied health professionals, and administrators. All participants completed a 60-minute interview, which was audio recorded, transcribed verbatim, and subjected to thematic analysis. Four themes were identified: Types of Chronic Health Conditions Treated, Access to Mental Health Services, Provider Experience and Comfort, and Educational Needs. Participants expressed a willingness to complete mental health training but faced challenges identifying particular training needs. Future training efforts should address foundational knowledge in mental health disorders and strategies to serve people with common mental health comorbidities.