bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of ABO Blood Group Susceptibility to Coronavirus Disease - COVID-19
Authors: Bommanavar Sushma , Patil V C , Luke Alexander Maniangat , Jaber Mohamed , Hosmani Jagadish 
Published: January 2022

Background:
The pandemic outbreak of COVID-19 highlighting the zoonotic cross-over link in the present century has provoked an emergency worldwide. Recent experimental evidence supporting the proposition of ABO blood grouping and its susceptibility in certain blood group individuals has created interest among researchers to explore more.

Aim:
The aim of this study is to find the susceptibility of “ABO” blood group in COVID-19-positive cases.

Objectives:
Association of ABO blood group patterns with COVID-19-positive cases.

Materials and Methods:
A cross-sectional, observational study design was conducted among 728 confirmed positive COVID-19 admitted to the tertiary health care center in Maharashtra from June 01, 2020 to August 31, 2020. The inclusion criteria were COVID-19-positive cases confirmed by positive real-time reverse transcriptase-polymerase chain reaction test of severe acute respiratory syndrome coronavirus 2. We collected the demographic details, associated clinical symptoms and ABO blood groups from all the patients. The data collected were subjected to statistical analysis.

Results:
The most common blood group affected was B + (35.5%) followed by A + (26.10%), AB + (20.60%) and O + (11.18%) and the least common was AB- (0.96%), O- (1.51%), A- (1.65%) and B- (1.79%).

Conclusions:
ABO blood grouping can be used as one of the simplest yet efficient markers for COVID-19. Blood group B Rh-positive and A Rh-positive were the most prevalent blood group types in patients with COVID-19.
Quantification of mast cells in nonreactive and reactive lesions of gingiva
Authors: Jain Amisha , Jaiswal Shradha , Vikey Ashok , Bagulkar Bhupesh , Bhat Atul , Shujalpurkar Anjali 
Published: January 2022

Background:
Mast cells (MCs) are immune cells derived from a multipotent CD34 precursor. The most significant identifying feature of MCs is the presence of metachromatic granules. MCs are increased in oral reactive lesions and are possibly involved in pathogenesis of these lesions.

Objectives:
1. To compare the number of MCs between reactive and nonreactive lesions of gingiva using toluidine blue (TB) and mast cell tryptase (MCT) as a specific marker for MCs 2. To compare the staining specificity/efficacy of TB and MCT.

Methodology:
The study sample comprised 90 tissues which were divided into three groups: Group A comprised 30 cases of pyogenic granuloma (PG), Group B consisted of 30 cases of gingival hyperplasia (GH) and Group C comprised 30 cases of pericoronitis. Staining was done between 1% TB and immunohistochemistry (IHC) marker MCT.

Results:
A significant increase in number of MCs was observed in PG as compared to GH and pericoronitis. IHC marker MCT proved to be a more specific marker for MCs compared to TB.

Conclusion:
IHC marker MCT is a specific marker compared to TB. The position of MCs changed from juxtaepithelial in GH to deeper connective tissue in PG which was in correlation with the proliferating tissue that is epithelium in GH and blood vessel in PG.
Reliability of palatal rugae patterns in individual identification
Authors: Smitha T , Vaswani Vina , Deepak V , Sheethal H S , Hema K N , Jain Vijay Kumar 
Published: January 2022

Background:
Dental identification plays a major role in mass disaster identification of human remains. Palatal rugae can be used as a substitute for a comparative method of identification.

Materials and Methods:
The present cross-sectional study was done with 137 pre- and post-orthodontically treated casts of patients, which were divided into 50 cases each of extraction and nonextraction and 37 cases of palatal expansion involving both extraction and nonextraction. Hydrocolloid (alginate) impression of the upper jaw of the patient was taken and then cast in the dental plaster of Paris material. Palatal rugae pattern was classified according to Lysellm, and Thomas and Kotze classification. Two Observers recorded the data, mean of two were taken for analysis.

Results:
On the right side, there was no significant difference between the extraction and nonextraction groups; however, there was a rise in length in the nonextraction and palatal expansion groups. On the left side, there was little change between the nonextraction and palatal expansion groups, but the extraction group had a modest increase in length. Mean lengths compared within three groups revealed insignificant difference.

Conclusion:
Palatal rugae pattern can be used in establishing identity in forensic medicine provided antemortem data are available. Orthodontic treatment has an impact on stability of palatal rugae. Most reliable and stable points being third rugae, they could be used as reference points to evaluate tooth movements
Analysis of antimicrobial activity of Karnataka propolis against oral pathogens – An in vitro study
Authors: Srinivas Sowmya , Gujjari Anil Kumar , Kenganora Mruthunjaya , Rudraswamy Sushma , Ravi M B , Manjula S 
Published: January 2022

Background:
Propolis, a natural antibiotic, which is in high demand in dentistry is a resinous substance. The main ingredient of propolis that is required for antibiotic effect is flavonoids and phenolic acids. Although propolis is a promising option for the control of oral microbes with lower related hazards and a good immunomodulator effect, its composition differs considerably depending on its botanical origin, the site and the season of collection. This original research aims to find the chemical composition and minimum inhibitory concentration (MIC) of propolis procured from different places of Karnataka state. The results would help the dentist and the pharmacist to select the best propolis to use as antibiotics in treating oral disease.

Materials and Methods:
Propolis sample from 5 different locations of Karnataka was procured from single apiary in Bangalore. Extraction of propolis using two different extracting solvents was carried out. The total phenolic content, total flavonoid content and MIC of each sample were analyzed.

Results:
Water extract propolis of Sullia and Hubli was highly active against tested organism with the MIC <0.312; alcohol extract of Sullia, Hubli and Chitradurga was moderately active with the MIC between 0.312 and 5 mg/ml. Vijayapura and Bagalkot were least active with the MIC >5 mg/ml at tested concentration.

Conclusion:
Propolis procured from different locations of Karnataka can be used as an antimicrobial agent with varying concentrations. However, when propolis is procured for therapeutic purpose, then it needs to be tested for its chemical composition before being utilized.
Radıologıcal Evaluatıon of the Recesses on the Posterıor Wall of the Nasopharynx wıth Cone-beam Computed Tomography
Authors: Kaplan FA , Sağlam H , Bilgir E , Bayrakdar İŞ , Orhan K 
Published: January 2022

ABSTRACT

Background:
The posterior wall of the nasopharynx is composed of loose connective tissue that includes many important anatomical structures. Various structures, such as the opening of the Eustachian tube (ET), the Rosenmüller fossa (RF), and the pharyngeal bursa (PB) are found here.

Aim:
To evaluate the nasopharynx posterior wall anatomic structures, including the Eustachian tube, Rosenmüller fossa, and pharyngeal bursa with cone-beam computed tomography.

Materials and Methods:
The depth, width, and length of the Eustachian tube, Rosenmüller fossa, and pharyngeal bursa were measured in 150 patients using axial-sagittal cone-beam computed tomography. The Eustachian tube and Rosenmüller fossa distance to the midsagittal plane, the coronal region passing through the posterior end of the nasal septum, the superior-inferior extremity of the recesses, and the nasal floor plane distance were measured. The relationship between Rosenmüller fossa types and other parameters were evaluated.

Results:
The incidence of right Rosenmüller fossa types 1, 2, and 3 were 16%, 18%, and 66%, respectively, and that of the left Rosenmüller fossa types 1, 2, and 3 were 16%, 19.3%, and 64.7%, respectively. The mean pharyngeal bursa width, length, and depth were 10.8, 5.7, and 4.0 mm, respectively; those of the Eustachian tube were 5.6, 7.1, and 7.3 m, respectively; those of the right Rosenmüller fossa were 4.0, 12.4, and 10.5 mm, respectively; and those of the left Rosenmüller fossa were 3.8, 12.5, and 10.9 mm, respectively.

Conclusions:
The posterior wall of the nasopharynx contains several important anatomical structures. Evaluation of these using cone-beam computed tomography has many clinical and radiological advantages. To understand and interpret the coincidental findings in CBCT, dental radiologists should have access to more detailed information concerning the anatomy of the nasopharynx.
Factors Affecting Breastfeeding within the First Hour After Birth
Authors: Dudukcu FT , Aygor H , Karakoç H 
Published: January 2022

ABSTRACT

Background:
Every baby should start life with breastfeeding. However, some obstacles prevent babies from enjoying this right.

Aim:
This study aimed to determine the factors affecting breastfeeding within the first hour after birth.

Patients and Methods:
This study employed a comparison design. This was a comparative study of women who breastfeed their babies within 1 h of birth and those who did not. The research population consisted of 368 mothers who had babies aged 6–24 months. A semi-structured questionnaire, which consisted of 32 open-.and closed-ended questions, was used to collect data. The number and proportions were used for the descriptive statistics, and Chi-square tests were used to compare data between groups. The level of statistical significance was accepted as P < 0.05.

Results:
Of the 368 participants, 50.8% breastfed their babies within the first hour after birth, 49.2% did not breastfeed within the first hour, 51.6% exclusively breastfed in the first 6 months, 48.4% did not breastfeed exclusively in the first 6 months. Moreover, results revealed that a high-risk pregnancy status, mode of delivery, prelacteal food, and the mother's role in making decisions about baby feeding affects breastfeeding practices within the first hour after birth.

Conclusions:
Initiatives should be increased to start breastfeeding within the first hour after birth in women who have high-risk pregnancy and those giving birth by cesarean section. Breast milk should be the baby's first food, and mothers should be the primary decision-makers in baby's nutrition.
Role of yoga as an adjuvant therapy in the management of metabolic syndrome – A randomized control pilot study
Authors: Balaji Rajasekaran , Ramanathan Meena , Bhavanani Ananda Balayogi 
Published: January 2022

Introduction:
Metabolic syndrome (MetS) is a public health threat rising globally at an alarming rate. Yoga as a therapy is becoming increasingly popular and its applications are increasing in various clinical conditions. Yoga is an integrated system of self-culturing, aimed at coordinated development of body and mind leading to enhanced physical health, spiritual harmony, positive thinking, happiness and peace.

Aim:
This study aimed to study the role of yoga as adjuvant therapy in the clinical management of MetS.

Methods:
The study was done an interdisciplinary collaborative work between Center for Yoga Therapy and Department of General Medicine of MGMCRI, Sri Balaji Vidyapeeth, Puducherry. Thirty newly diagnosed MetS patients were recruited; prestudy evaluations of body mass index, waist circumference, hip circumference, pulse rate, systolic blood pressure (SP), diastolic blood pressure (DP), fasting blood sugar, postprandial blood sugar, glycosylated hemoglobin, and fasting lipid profile were done. By the method of simple randomization, subjects were allocated to yoga therapy group (n = 15), who received yoga therapy thrice weekly for 3 months along with standard medical management and to control group (n = 15) who received only standard medical management. Poststudy evaluation of all parameters was done at the end of the study period. Data were analyzed by Student's paired 't' test, as all data passed normality.

Results:
There was a statistically significant (p < 0.05) reduction in all the above parameters in yoga group compared to control group. Changes seen in control group were missing significance.

Conclusion
s: It may be concluded from the present pilot study that adjuvant yoga therapy is beneficial in maintaining good health and reducing metabolic risk factors. This may have impact on utilization of yoga therapy as a secure and cost-effective add-on therapeutic modality in combating MetS.
Kinetics and thermodynamics of enhanced adsorption of E120 dye using activated carbon
Authors: Mahnashi Mater H. , Abu-Alrub Samer S. , Amer Mohammad W. , Alqarni Ali O. 
Published: January 2022

Purpose: To study the adsorption of dye (E120) from aqueous solution onto activated carbon.
Method: Factors influencing adsorption were examined and optimized. Three adsorption isotherm models (Langmuir, Freundlich and Temkin) were investigated. Agitation time was set at 72 hours, E120 dye concentration at 10 – 80 mg/L, pH at 7, temperature at 25°C and mass at 125 mg.
Results: Adsorption of E120 dye onto activated carbon was enhanced by decreasing the mass of activated carbon, pH and ionic strength of the solution and by increasing the temperature. Under optimal conditions, the maximum adsorption capacity of activated carbon for E120 dye was 10.1 mg/g at 30°C. The model parameters were 0.307 L/mg (KL), 10.1 mg/g (qm), 0.9491 (R2) for the Langmuir isotherm; 2.98 (n), 0.445 mg/g (Kf), and 0.6592 (R2) for Freundlich isotherm; and 4.59 mg/L (A), 2.23 J/mol (B), and 0.5914 (R2) for Temkin isotherm. Thermodynamic studies indicate that the adsorption of E120 dye onto activated carbon is an endothermic process with an adsorption enthalpy (ΔH) of 8.7 KJ/mol. The positive values for ΔG indicate that adsorption was non-spontaneous. The kinetic study of E120 dye adsorption showed that the adsorption process obeyed pseudo-second order kinetics.
Conclusion: Commercially available activated carbon, in terms of its physical and chemical characteristics, is a superior adsorbent to other adsorbents mentioned in the literature for removal of toxic dye E120 from aqueous solutions at a high removal capacity.
Molecular modelling studies and synthesis of novel quinoxaline derivatives with potential inhibitory effect on GSK-3β
Authors: Swellmeen Lubna , Uzrail Amal , Shaheen Rand , Al-Hiari Yusuf 
Published: January 2022

Purpose: To synthesize quinoxaline derivatives and investigate their inhibitory effects on glycogen synthase kinase (GSK)-3β in vitro.
Methods: Quinoxaline derivatives were synthesized via reaction between synthon 1 and DL- 2-amino succinic acid, and subsequent lactamization reaction. The new compounds were tested against GSK-3β in vitro to select the most potent compound which was then used for molecular modelling.
Results: Novel quinoxaline derivatives with quinolone nucleus were successfully synthesized via simple chemical reactions. The compounds markedly inhibited GSK-3β, with compound 45 [3-(carboxymethyl)- 5-fluoro-10-(4-fluorophenyl)-2,7-dioxo-1,2,3,4,7,10-hexahydropyrido [2,3-f] quinoxaline-8-carboxylic acid] achieving the best effect (IC50 = 0.18 μM). The half maximal inhibitory concentrations (IC50) of the compounds were in micromolar range. Molecular modelling revealed several interactions between compound 45 and the binding site of GSK-3β.
Conclusion: These results indicate that 3-(carboxymethyl)-5-fluoro-10-(4-fluorophenyl)-2,7-dioxo- 1,2,3,4,7,10-hexahydropyrido [2,3-f] quinoxaline-8-carboxylic acid is a potent inhibitor of GSK-3β and is thus a promising scaffold for the development of novel drugs that can effectively inhibit GSK-3β signaling pathway.
Urine metabonomic study on primary liver cancer with spleen deficiency and excess dampness syndrome based on ultra-performance LC-MS
Authors: Jingjie Li , Shumei Liu , Dong Wang , Jiang Liu , Shuqin Lv 
Published: January 2022

Purpose: To investigate spleen deficiency and excess dampness syndrome (SDES) in primary liver cancer (PLC) and the underlying mechanism using ultra pressure liquid chromatography-mass spectrometry (UPLC-MS).
Methods: Ultra-performance liquid chromatography coupled with mass spectrometry (UPLC-MS) was used to detect urine metabolites from untreated and IPED-treatment PLC-SDES patients. The metabolites were annotated using Kyoto Encyclopedia of Genes and Genomes (KEGG), Human Metabolome Database (HMDB), and Lipidmaps. Principle component analysis (PCA) and partial least squares to latent structure-discriminant analysis (PLS-DA) models were built to reveal the metabolic differences between untreated, IPED-treated patients and healthy controls. The differential metabolites in PLC-SDES patients were screened according to variables important in the project (VIP) and p-value.
Results: In urine, 537 metabolites (256 in negative and 281 in positive mode) were considered differential in PLC-SDES patients when compared to healthy controls. In untreated patients, 100 metabolites (38 in negative and 62 in positive mode) were differential when compared to IPED-treatment patients. The urine of PLC-SDES patients showed overlap of 32 metabolites.
Conclusion: The results reveal comprehensive urine metabonomic changes in PLC-SDES patients, relative to healthy controls and IPED-treated patients. The identified metabolites may be potential biomarkers for diagnosis and IPED therapy.
Absence of Germline BRCA1 c.68_69delAG and c.5266dupC Mutations among Hormone Receptor-negative Breast Cancer Patients: A First Impression at a Tertiary Cancer-care Facility in Tanzania
Authors: Rweyemamu Linus P , Akan Gokce , Mbotwa Christopher H , Dharsee Nazima , Namkinga Lucy A , Lyantagaye Sylvester L , Mselle Ted F , Atalar Fatmahan 
Published: January 2022

The germline BRCA1 c.68_69delAG (185delAG) and c.5266dupC (5382insC) mutations are associated with hormone receptor-negative breast cancer (BC). Limited studies have examined their contribution to alarming BC incidence in Sub Saharan Africa (SSA). Our study aimed to examine the contribution of germline BRCA1 c.68_69delAG and c.5266dupC mutations to BC incidence among hormone receptor-negative BC patients admitted to Ocean Road Cancer Institute in Tanzania. Face-to-face interviews were conducted to capture socio-demographic characteristics, anthropometric measurements, family history of cancer and reproductive information from each patient. Their histopathological data were extracted from the hospital medical records. The germline BRCA1 founder mutations were analyzed on blood samples using Sanger sequencing technology. The patients mean age at diagnosis was 47.05 ± 12.82 years. A family history of cancer was observed in 13.6% of patients. The germline BRCA1 c.68_69delAG and c.5266dupC mutations were not detected in the study group. Our findings indicate that the germline BRCA1 c.68_69delAG and c.5266dupC mutations do not contribute to BC manifestation in hormone receptor-negative BC patients in Tanzania. Thus, screening BC patients for these mutations has no clinical relevance. Our data further suggest that the c.68_69delAG and the c.5266dupC mutations should not be considered when developing genetic testing guidelines in Tanzania.
Keywords: Breast cancer, germline BRCA1 mutation, c.68_69delAG (185delAG), c.5266dupC (5382insC), Tanzania
Descripción de la metodología aplicada en una investigación cualitativa en Expresión Corporal y Danza: la vida y obra de Patricia Stokoe (Description of the methodology applied in a qualitative research in Body Expression and Dance: the life and work of
Authors: Cardona Linares Antonio José , Herrador Sánchez Julio Ángel , Calvo Lluch África 
Published: January 2022

Los inicios de la Expresión Corporal (EC) han sido y están siendo analizados desde diferentes perspectivas. Este trabajo ha pretendido profundizar en los comienzos acaecidos a lo largo del siglo XX, en donde esta disciplina emergente se nutrió de múltiples fuentes: de lo social, las artes, la educación, la psicología, etc. Patricia Stokoe (1919-1996), dedicó su vida al estudio de la Expresión Corporal-Danza (ECy D). Considerada como una de las iniciadoras en este campo (Kalmar, 2005; Cardona, 2009; Ruano & Sánchez, 2009). Su obra sigue siendo referente en la actualidad y está presente en gran parte de la producción científica que se genera en esta disciplina. Es la investigación de Cardona (2009), en donde se ha profundizado en el estudio de la vida y la obra de la autora. Exponemos aquí cómo se llevó a cabo dicha investigación cualitativa. Se hizo un tratamiento descriptivo transversal, utilizando el análisis de documentos y las entrevistas. Realizamos más de treinta entrevistas entre Buenos Aires y España. Estableciéndose 4 dimensiones/campos que aportaron estructura y claridad al estudio: análisis de la vida; análisis de las influencias en la vida y la obra; análisis de la obra; ensayo bibliográfico de la obra. Se obtuvieron unos resultados y conclusiones que convierte a Patricia Stokoe en una de las pioneras en la construcción y génesis de la Expresión Corporal.
Abstract: The beginnings of corporal expression have been and are being analyzed from different perspectives. This work has attempted to delve into the beginnings that occurred throughout the 20th century, when this emerging discipline was nourished by multiple sources: society, arts, education, psychology, etc. Patricia Stokoe (1919-1996), devoted her life to the study of body language-dance. Considered one of the initiators in this field (Kalmar, 2005; Cardona, 2009; Ruano & Sánchez, 2009), her work continues to be a reference nowadays and it is present in a large part of the scientific production generated in this discipline. It is in the research by Cardona (2009), who carried out a doctoral thesis, where the study of the life and work of the author has been deepened. We present here how this qualitative research was carried out. A cross-sectional descriptive treatment was carried out, using the analysis of documents and interviews. We conducted more than thirty interviews between Buenos Aires and Spain, establishing 4 dimensions / fields that provided structure and clarity to the study: life analysis; analysis of the influences on life and work; analysis of the work; bibliographic essay of the work. We obtained results that make the life and work of Patricia Stokoe one of the pioneers in the construction and genesis of corporal expression.
Analisis Pengaruh Economic Value Added, Profitabilitas dan Market Value Added Terhadap Harga Saham Perusahaan
Authors: Rinofah Risal , Sari Pristin Prima , Amrina Heni    Nur 
Published: January 2022

The purpose of this study is to find out whether the effect of Market Value Added, Profitability, and Market Value Added on stock price. Sampling in this study is a purposive sampling method. Then the data is tested using multiple regression analysis. The results of the t test showed that the Economic Value Added has a signification value of 0,018 which means smaller than 0,05 and the calculated value of -2.441<t tablel 2.00758 then H1 is accepted. Profitability has a signification value of 0,034 greater than 0,05 and a calculated value of 2.182>t table 2.00758 then H2 is accepted, Market Value Added has significant value of 0,223 greater than 0,05 and the value of t calculated -1.235<t table 2.00758 then H3 is rejected. The results of the F test showed that Economic Value Added, Profitability, Market Value Added have a calculated F value of 2,933 and sig. 0,042. Because the value F calculated 2.933>F table 2.773 and sig. value 0,042<0,05. It can be concluded that partially Economic Value Added has a significant negative effect on stock price, Profitability has a significant effect on stock price, Market Value Added has no significant effect on stock price and simultaneously Economic Value Added, Profitability, Market Value Added has a significant effect on stock price
Keywords: Economic Value Added, Profitabilitas, Market Value Added, Stock Price