bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Interaction between DNMT1 and High‐Mannose CD133 Maintains the Slow‐Cycling State and Tumorigenic Potential of Glioma Stem Cell
Authors: Wei Yuanyan , Chen Qihang , Huang Sijing , Liu Yingchao , Li Yinan , Xing Yang , Shi Danfang , Xu Wenlong , Liu Weitao , Ji Zhi , Wu Bingrui , Chen Xiaoning , Jiang Jianhai 
Published: July 2022

AbstractThe quiescent/slow‐cycling state preserves the self‐renewal capacity of cancer stem cells (CSCs) and leads to the therapy resistance of CSCs. The mechanisms maintaining CSCs quiescence remain largely unknown. Here, it is demonstrated that lower expression of MAN1A1 in glioma stem cell (GSC) resulted in the formation of high‐mannose type N‐glycan on CD133. Furthermore, the high‐mannose type N‐glycan of CD133 is necessary for its interaction with DNMT1. Activation of p21 and p27 by the CD133–DNMT1 interaction maintains the slow‐cycling state of GSC, and promotes chemotherapy resistance and tumorigenesis of GSCs. Elimination of the CD133–DNMT1 interaction by a cell‐penetrating peptide or MAN1A1 overexpression inhibits the tumorigenesis of GSCs and increases the sensitivity of GSCs to temozolomide. Analysis of glioma samples reveals that the levels of high‐mannose type N‐glycan are correlated with glioma recurrence. Collectively, the high mannose CD133–DNMT1 interaction maintains the slow‐cycling state and tumorigenic potential of GSC, providing a potential strategy to eliminate quiescent GSCs.
Synergic Effect of Dendrite‐Free and Zinc Gating in Lignin‐Containing Cellulose Nanofibers‐MXene Layer Enabling Long‐Cycle‐Life Zinc Metal Batteries
Authors: Liu Chaozheng , Li Zhenglin , Zhang Xiaoman , Xu Wangwang , Chen Weimin , Zhao Kangning , Wang Yao , Hong Shu , Wu Qinglin , Li Mei‐Chun , Mei Changtong 
Published: July 2022

AbstractUncontrollable zinc dendrite growth and parasitic reactions have greatly hindered the development of high energy and long life rechargeable aqueous zinc‐ion batteries. Herein, the synergic effect of a bifunctional lignin‐containing cellulose nanofiber (LCNF)‐MXene (LM) layer to stabilize the interface of zinc anode is reported. On one hand, the LCNF provides enough strength (43.7 MPa) at relative low porosity (52.2%) to enable the diffusion limited dendrite suppression, while, on the other hand, the MXene serves as a zinc gating layer, facilitating the zinc ion mobility, restricting the active water/anions from degradation in the electrode/electrolyte interface, and epitaxially guiding zinc deposition along (002) plane. Benefiting from the synergic effect of diffusion limited dendrite suppression and zinc gate, the LM layer enabled a high coulombic efficiency (CE) of 98.9% with a low overpotential of 43.1 mV at 1 mA cm−2 in Zn//Cu asymmetric cells. More importantly, Zn//MnO2 full cells with the LM layer achieve a high‐capacity retention of 90.0% for over 1000 cycles at 1 A g−1, much higher than the full cell without the protective layer (73.9% over 500 cycles). The work provides a new insight in designing a dendrite‐free zinc anode for long‐cycle‐life batteries.
Color‐Tuning Mechanism of Electrically Stretchable Photonic Organogels
Authors: Shin Jun Hyuk , Park Ji Yoon , Han Sang Hyun , Lee Yun Hyeok , Sun Jeong‐Yun , Choi Su Seok 
Published: July 2022

AbstractIn contrast to nano‐processed rigid photonic crystals with fixed structures, soft photonic organic hydrogel beads with dielectric nanostructures possess advanced capabilities, such as stimuli‐responsive deformation and photonic wavelength color changes. Recenlty, advanced from well‐investigated mechanochromic method, an electromechanical stress approach is used to demonstrate electrically induced mechanical color shifts in soft organic photonic hydrogel beads. To better understand the electrically stretchable color change functionality in such soft organic photonic hydrogel systems, the electromechanical wavelength‐tuning mechanism is comprehensively investigated in this study. By employing controllable electroactive dielectric elastomeric actuators, the discoloration wavelength‐tuning process of an electrically stretchable photonic organogel is carefully examined. Based on the experimental in‐situ response of electrically stretchable nano‐spherical polystyrene hydrogel beads, the color change mechanism is meticulously analyzed. Further, changes in the nanostructure of the symmetrically and electrically stretchable organogel are analytically investigated through simulations of its hexagonal close‐packed (HCP) lattice model. Detailed photonic wavelength control factors, such as the refractive index of dielectric materials, lattice diffraction, and bead distance in an organogel lattice, are theoretically studied. Herein, the switcing mechanism of electrically stretchable mechanochromic photonic organogels with photonic stopband‐tuning features are suggested for the first time.
World agricultural baseline scenarios through 2050
Authors: Sands Ronald D. , Suttles Shellye A. 
Published: July 2022

AbstractThe European Green Deal aims to reduce net greenhouse gas emissions to zero by 2050. The effort required to meet greenhouse gas emission targets or other sustainable development goals depends on the difference between baseline levels and policy targets. This paper provides a set of plausible world agricultural baseline scenarios through 2050 with a variety of agricultural indicators: food calories consumed, crop calories produced, average crop yields, and associated greenhouse gas emissions. Growth of agricultural activity varies widely across world regions, from Europe with a relatively stable population to sub‐Saharan Africa with rapidly growing populations and per‐capita incomes.
Cadmium concentrations in Idaho wheat grain and soil
Authors: Strawn Daniel G. , Mohotti Dinithi , Carp Elizabeth , Liang Xi , Chen Jianli , Schroeder Kurtis , Marshall Juliet 
Published: July 2022

AbstractCurrent efforts to reduce the maximum allowable cadmium (Cd) concentrations in wheat (Triticum aestivum L.) for at‐risk populations such as infants require sourcing wheat with low concentrations of Cd. Since Idaho (USA) is a major wheat supplier, there is a need to understand which varieties and locations in Idaho produce wheat containing low Cd. Therefore, the main objective of this paper is to report on a survey of total Cd concentrations in 469 wheat grain samples and 216 soil samples from several varieties and locations throughout Idaho. Total Cd concentrations in wheat grain ranged from <0.01 to 0.28 mg kg−1, varying by both wheat variety and location grown. Total soil Cd ranged from 0.450 to 1.85 mg kg−1. Bioaccumulation factor (BAF) was calculated by dividing the grain total Cd concentration by the soil total Cd concentration and ranged from 0.05 to 0.5. The variety ‘UI Sparrow’ had the lowest mean BAF (0.06), and several other varieties were also relatively low. Overall, almost all wheat varieties meet European Food Safety Authority (EFSA) requirements for Cd concentration for adult consumption. However, meeting the EFSA maximum allowable limit of Cd in infant food requires planting varieties noted for low Cd uptake, like UI Sparrow, and careful selection of growing regions with the lowest total soil Cd, such as northern, central, or western Idaho.
Automated detection of mild cognitive impairment and dementia from voice recordings: A natural language processing approach
Authors: Amini Samad , Hao Boran , Zhang Lifu , Song Mengting , Gupta Aman , Karjadi Cody , Kolachalama Vijaya B. , Au Rhoda , Paschalidis Ioannis Ch. 
Published: July 2022

AbstractIntroductionAutomated computational assessment of neuropsychological tests would enable widespread, cost‐effective screening for dementia.MethodsA novel natural language processing approach is developed and validated to identify different stages of dementia based on automated transcription of digital voice recordings of subjects’ neuropsychological tests conducted by the Framingham Heart Study (n = 1084). Transcribed sentences from the test were encoded into quantitative data and several models were trained and tested using these data and the participants’ demographic characteristics.ResultsAverage area under the curve (AUC) on the held‐out test data reached 92.6%, 88.0%, and 74.4% for differentiating Normal cognition from Dementia, Normal or Mild Cognitive Impairment (MCI) from Dementia, and Normal from MCI, respectively.DiscussionThe proposed approach offers a fully automated identification of MCI and dementia based on a recorded neuropsychological test, providing an opportunity to develop a remote screening tool that could be adapted easily to any language.
The effects of coloring therapy on patients with generalized anxiety disorder
Authors: Samuel Bosomtwe , Wang Hongmei , Shi Chengdong , Pan Yongliang , Yu Yuzi , Zhu Weiyu , Jing Zhou 
Published: July 2022

AbstractGeneralized anxiety disorder (GAD) has harmful effects on physical and mental health and quality of life. Coloring therapy has been reported to have a positive effect on improving patient anxiety and depression. But there are no reported clinical trials examining their effectiveness as a treatment for GAD. This study was planned to evaluate the effectiveness of coloring therapy combined with conventional therapy in improving anxiety, depression, and positive and negative emotions with GAD. This randomized controlled study comprising 88 GAD patients was selected for intervention in different wards. The control group (n = 45) was given conventional antianxiety medication and physical therapy, and the experimental group (n = 43) received coloring therapy combined with conventional therapy. The Self‐Rating Depression Scale, Self‐Rating Anxiety Scale (SAS), Hamilton Depression Scale, Hamilton Anxiety Scale (HAMA), and Positive and Negative Affect Scale were assessed in both groups before and 3 weeks after the intervention. After the intervention, there were statistical differences in intra‐ and inter‐group comparisons of anxiety, depression, and positive and negative mood scales in the experimental and control groups (p < .05). The minus in anxiety/positive emotions pre‐ and postintervention in the experimental group was statistically significant compared to that in anxiety/positive emotions pre‐ and postintervention in the control group (HAMA: d = 1.45, 95% confidence interval [CI] (0.34, 2.57), p = .011; SAS: d = 3.87, 95% CI (1.73,6.00), p = .001; positive: d = 1.76, 95% CI (0.17, 3.34), p = .030). The minus in depressive/negative emotions pre‐ and postintervention in the experimental group was not statistically significant compared with that in depressive/negative emotions pre‐ and postintervention in the control group (p > .05). For GAD patients, adding coloring therapy based on conventional drug therapy and physical therapy can not only reduce depression and negative emotions but also have better effects on reducing anxiety and improving positive emotions than conventional therapy.
Annual Development Performance of Fixed Honeybee Colonies Linked with Chemical and Mineral Profile of Bee Collected Pollen
Authors: Topal Erkan , Çakıcı Neslihan , Mărgăoan Rodica , Takma Çiğdem , Güney Fazıl , Kösoğlu Mustafa , Cornea‐Cipcigan Mihaiela , Atmaca Hilal 
Published: July 2022

AbstractClimate change affects plant phenology and, as a result, can damage nectar and pollen sources, which are the basic needs of bees during flowering. This situation creates nutritional stress for bee colonies in the region. Changing climatic conditions, the use of agricultural lands adversely affects honeybees and beekeepers. The aim of this study is to determine the annual development performance of fixed honeybee colonies linked with the chemical and mineral profile of bee collected pollen. According to the research findings, in terms of colony development parameters, the number of bee frames (9.17) was found to be at the highest level in May, and in terms of brood area (4652.35 cm2) in April (P<0.05). March, April, and May are the most abundant months in terms of pollen collection of the colonies (P<0.05). The pollen samples collected are rich in potassium, sodium, calcium, magnesium, silicon, and iron. There are differences between months in terms of pollen sources and mineral levels. Especially in stationary beekeeping, additional feeding is required during critical periods. The existing flora is insufficient for the future of the honey bee. In periods when the flora is weak, important plants for the honey bee should be grown in the region.
Crop yield and estimated financial return from subsurface drip irrigation for corn, cotton, and peanut over the life of the system
Authors: Jordan David , Wells Randy , Washburn Derek , Barnes Steve , Corbett Tommy 
Published: July 2022

Core Ideas
Subsurface drip irrigation increased corn, cotton, and peanut yield in some (not all) years.
Financial returns over the irrigation system's life did not differ from dryland production.
Subsurface irrigation supports economic viability some years but not over the system's life.
Pharmacokinetic and Safety Comparison of 2 Afatinib Dimaleate Tablets in Healthy Chinese Volunteers Under Fasted Conditions: A Randomized, Open‐Label, 2‐Period, Single‐Dose Crossover Study
Authors: Shi Ping , Jiang Xin , Tao Ye , Li Ting , Li Xin , Wang Chenjing , Liu Yanping , Ma Yaping , Gao Xiaomeng , Cao Yu 
Published: July 2022

AbstractIn this bioequivalence study, we aimed to evaluate the bioequivalence of test (T) and reference (R) afatinib dimaleate tablets in healthy Chinese subjects under fasted conditions. This was a randomized, open‐label, 2‐period, single‐dose, crossover study. A total of 60 healthy subjects were included in the study according to the screening criteria, and the subjects were randomly divided into the T/R and R/T groups. All subjects were administrated a single 40‐mg oral dose of the test or reference formulation, separated by a 14‐day washout period in the crossover manner. The pharmacokinetic parameters, including maximum concentration (Cmax), area under the concentration‐time curve (AUC) from time 0 to the last measurable concentration and AUC from time 0 to infinity were assessed for bioequivalence. The plasma concentrations of afatinib dimaleate were analyzed by liquid chromatography–tandem mass spectrometry. In addition, adverse events were monitored and recorded on the basis of patient interviews and physical examinations to assess the safety of the 2 formulations. There were 4 subjects who withdrew before the dosing of period 2. The 90%CIs of geometric mean ratios of Cmax, AUC from time 0 to the last measurable concentration, and AUC from time 0 to infinity were 95.9% to 104.1%, 98.8 % to 104.1%, and 98.9% to 104.0%, respectively, all of which were within the bioequivalence range of 80.0% to 125.0%. This randomized study demonstrated that the test formulation of afatinib was bioequivalent to the reference formulation in healthy Chinese subjects under fasted conditions. Both formulations were well tolerated, and no serious adverse events were observed during the study.
Retracted: Intrusion detection in cloud environment using hybrid genetic algorithm and back propagation neural network
Authors: S Manimurugan , P Manimegalai , Valsalan Prajoona , J Krishnadas , C Narmatha 
Published: July 2022

SummaryS M, P M, Valsalan P, J K, C N. Intrusion detection in cloud environment using hybrid genetic algorithm and back propagation neural network, International Journal of Communication Systems 2020, (https://doi.org/10.1002/dac.4667). The above article published online on 09 November 2020 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the Editor and John Wiley and Sons Ltd. Following publication, it has come to our attention that the people named as the Guest Editors of the Special Issue were being impersonated by a fraudulent entity and the articles were not reviewed in line with the journal's peer review standards. The Editor has determined that the articles do not meet the required scholarly standards of the journal, and therefore has taken the decision to retract the article. We did not find any evidence of misconduct by the authors. The authors have been informed of the decision to retract.
Changes in hibernating tricolored bat (Perimyotis subflavus) roosting behavior in response to white‐nose syndrome
Authors: Loeb Susan C. , Winters Eric A. 
Published: July 2022

AbstractUnderstanding animals' behavioral and physiological responses to pathogenic diseases is critical for management and conservation. One such disease, white‐nose syndrome (WNS), has greatly affected bat populations throughout eastern North America leading to significant population declines in several species. Although tricolored bat (Perimyotis subflavus) populations have experienced significant declines, little research has been conducted on their responses to the disease, particularly in the southeastern United States. Our objective was to document changes in tricolored bat roost site use after the appearance of WNS in a hibernaculum in the southeastern U.S. and relate these to microsite temperatures, ambient conditions, and population trends. We censused a tricolored bat hibernaculum in northwestern South Carolina, USA, once each year between February 26 and March 2, 2014–2021, and recorded species, section of the tunnel, distance from the entrance, and wall temperature next to each bat. The number of tricolored bats in the hibernaculum dropped by 90.3% during the first 3 years after the arrival of WNS. However, numbers stabilized and slightly increased from 2018 to 2021. Prior to the arrival of WNS, 95.6% of tricolored bats roosted in the back portion of the tunnel that was the warmest. After the arrival of WNS, we observed a significant increase in the proportion of bats using the front, colder portions of the tunnel, particularly during the period of population stabilization and increase. Roost temperatures of bats were also positively associated with February external temperatures. Our results suggest that greater use of the colder sections of the tunnel by tricolored bats could have led to increased survival due to slower growth rates of the fungus that causes WNS in colder temperatures or decreased energetic costs associated with colder hibernation temperatures. Thus, management actions that provide cold hibernacula may be an option for long‐term management of hibernacula, particularly in southern regions.
Warming shifts soil microbial communities and tropical tree seedling mortality
Authors: Liu Yu , He Fangliang 
Published: July 2022

AbstractPlant–soil feedback (PSF), regulated by both mycorrhizae and soil‐borne pathogens, is a primary mechanism maintaining high tree species diversity in the tropics. But how warming actually affects PSF is not well understood. We conducted a field warming experiment to test PSF on seedling mortality of two tree species: a rhizobia‐associated tree (Ormosia semicastrata, Fabaceae) suffering from host‐specific soil‐borne pathogens and an ectomycorrhizal fungi‐associated tree (Cyclobalanopsis patelliormis, Fagaceae) with low susceptibility to soil‐borne pathogens. Soil fungi from the warming versus control seedling plots were identified by molecular sequencing. Results showed that the elevated temperature lowered seedling mortality of O. semicastrata, but had no effect on C. patelliormis seedlings. This indicates that warming weakened the negative PSF on O. semicastrata, presumably due to the observed decrease of the relative abundance of plant‐pathogenic fungi and increase of ectomycorrhizal fungi but did not affect the PSF on C. patelliormis. The differential warming effects on seedling mortality of species with different microbial associations affords an example showcasing how the change in soil‐borne microbes in response to global warming would, in turn, through PSF, alter tropical tree species composition and diversity. This study helps shed mechanistic light on the debate of biodiversity change as driven by climate change.
Environmental DNA dynamics during embryonic development in the rare minnow Gobiocypris rarus
Authors: Shu Lu , Peng Zuogang 
Published: July 2022

AbstractUnderstanding environmental DNA (eDNA) dynamics in the major developmental stages of fish species is fundamental for developing eDNA methods to aid conservation and management of fish species and/or populations. In this study, we used the model fish species, the rare minnow (Gobiocypris rarus), to assess the temporal changes of its mitochondrial and nuclear eDNA concentrations during its embryonic development in a culture dish experiment. Mitochondrial cytochrome b (Cytb) and nuclear internal transcribed spacer‐1 (ITS1), considered as representative DNA fragments, were amplified by quantitative PCR (qPCR). In this embryo culture trial, spikes in mitochondrial (mt‐) and nuclear (nu‐) eDNA concentrations were found just after egg fertilization and after embryo hatching, and a modest but positive relationship was found between the eDNA concentration and the number of hatched individuals, illustrating eDNA may be used to monitor the spawning and hatching events of externally fertilizing fishes. These findings provided basic information on eDNA dynamics during fish embryonic development and a new insight to design eDNA methods to monitor early developmental stages of fish species.
Brentuxinmab vedotin, alone or combine with bendamustine in the treatment of natural killer T cell lymphoma
Authors: Zhang Ping , Shi Cunzhen , Song Yue , Li Zhaoming , Zhang Mingzhi , Jin Mengyuan 
Published: July 2022

AbstractNatural killer (NK)/T cell lymphoma is a highly aggressive subtype of non‐Hodgkin lymphoma. The prognosis of patients with natural killer T cell lymphoma (NKTCL) remains poor. More potent treatment strategies are urgently needed to improve the survival of these patients with R/R NKTCL. CD30 expression has been reported to occur in about 40% of NK/T cell lymphoma. Brentuximab vedotin (BV), a monomethyl auristatin E conjugated CD30 antibody, targets CD30 to kill cancer cells. Therapeutic combination of BV and bendamustine has been shown to be highly effective in Hodgkin lymphoma. We investigated efficacy of BV in treating NKTCL as a single therapy, and in combination with bendamustine in vitro and in vivo. We determined CD30 expression levels in 6 NKTCL cell lines. The efficiency of lymphoma cell inhibition by BV correlates with CD30 expression. We also determined the efficacy of BV in combination with bendamustine and found synergistic effects with bendamustine in NKTCL. Combined BV and bendamustine treatment exerted synergistic antiproliferation effect and enhanced cell apoptotic in vitro and in vivo. Brentuximab vedotin and bendamustine synergistically arrested cell cycle at the G2/M phase in NKTCL cell lines. The combination of BV and bendamustine was demonstrated to synergistically damage DNA in NKTCL. This study provides a reference for possible application on using BV for the treatment of NKTCL, either as a single agent or in combination with bendamustine.