bluuebunny/crossref_metadata_2025_split huggingface dataset:
Agriculture Productivity and Economic Growth in India: An Ardl Model
Authors: Ansari Shoaib , Ashkra . , Jadaun Krishna Kumar 
Published: September 2022

Purpose: The research aims to investigate agricultural production and its influence on India's economic growth.
Methods: The ADF test has been used to determine variable stationarity. Using secondary data from 1991 to 2020, the ARDL Model was used to estimate the long-run and short-run links between agricultural production and economic growth.
Findings: Our empirical findings reveal that the GCF and inflation rate are negatively correlated with economic growth in the short and long term. In contrast, all other factors have a positive link with economic growth.
Research Implication: We believe that The government has employed various tactics to maintain farm prices and profits. They imposed production limitations and subsidy programs that made direct payments to farmers. It is more efficient for the government to supply farmers with the required inputs, and farmers can use those cost-effective inputs in various agricultural operations.
Future Research Suggestion: The research has certain flaws because it only looks at five different crops and evaluates their influence on economic expansion over the previous three decades. The new study, with its many variables and long year, presents an opportunity to boost India's agricultural output, despite the fact that it has several flaws.
Association of Follow-up Blood Cultures With Mortality in Patients With Gram-Negative Bloodstream Infections
Authors: Thaden Joshua T. , Cantrell Sarah , Dagher Michael , Tao Yazhong , Ruffin Felicia , Maskarinec Stacey A. , Goins Stacy , Sinclair Matthew , Parsons Joshua B. , Eichenberger Emily , Fowler Vance G. 
Published: September 2022

ImportanceObtaining follow-up blood cultures (FUBCs) in patients with Staphylococcus aureus bloodstream infection (BSI) is standard practice, although its utility in patients with gram-negative bacterial BSI (GN-BSI) is unclear.ObjectiveTo examine whether obtaining FUBCs is associated with decreased mortality (key question [KQ] 1) and whether positive vs negative FUBCs are associated with increased mortality (KQ2).Data SourcesMEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Web of Science, and gray literature were searched from inception to March 11, 2022.Study SelectionTwo investigators used predefined eligibility criteria to independently screen titles, abstracts, and relevant full texts. Randomized clinical trials or observational studies that matched or statistically adjusted for differences in, at minimum, level of acute illness between patients in the intervention (eg, FUBCs obtained) and control (eg, FUBCs not obtained) groups were included in primary analyses. Articles published in languages other than English were excluded.Data Extraction and SynthesisData abstraction and quality assessments were performed by one investigator and verified by a second investigator. Risk of bias was assessed with the Newcastle-Ottawa Scale. Effect sizes were pooled using random-effects models. The study followed the Meta-analysis of Observational Studies in Epidemiology (MOOSE) reporting guideline.Main Outcomes and MeasuresMortality before hospital discharge or up to 30 days from the index blood culture.ResultsFrom 3495 studies, 15 were included (all nonrandomized). In the 5 studies (n = 4378 patients) that met criteria for the KQ1 primary analysis, obtaining FUBCs was associated with decreased mortality (hazard ratio, 0.56; 95% CI, 0.45-0.71). For KQ2, 2 studies met criteria for the primary analysis (ie, matched or statistically adjusted for differences in patients with positive vs negative FUBCs), so an exploratory meta-analysis of all 9 studies that investigated KQ2 (n = 3243 patients) was performed. Positive FUBCs were associated with increased mortality relative to negative blood cultures (odds ratio, 2.27; 95% CI, 1.54-3.34). Limitations of the literature included a lack of randomized studies and few patient subgroup analyses.Conclusions and RelevanceIn this systematic review and meta-analysis, obtaining FUBCs in patients with GN-BSI was associated with decreased mortality. The benefit of FUBCs may stem from identification of patients with positive FUBCs, which was a poor prognostic marker.
Association of Postpartum Maternal Mood With Infant Speech Perception at 2 and 6.5 Months of Age
Authors: Schaadt Gesa , Zsido Rachel G. , Villringer Arno , Obrig Hellmuth , Männel Claudia , Sacher Julia 
Published: September 2022

ImportanceLanguage development builds on speech perception, with early disruptions increasing the risk for later language difficulties. Although a major postpartum depressive episode is associated with language development, this association has not been investigated among infants of mothers experiencing a depressed mood at subclinical levels after birth, even though such a mood is frequently present in the first weeks after birth. Understanding whether subclinical depressed maternal mood after birth is associated with early language development is important given opportunities of coping strategies for subclinical depressed mood.ObjectiveTo examine whether depressed maternal mood at subclinical levels 2 months after birth is associated with infant speech perception trajectories from ages 2 to 6.5 months.Design, Setting, and ParticipantsIn this longitudinal cohort study conducted between January 1, 2018, and October 31, 2019, 46 healthy, monolingual German mother-infant dyads were tested. The sample was recruited from the infants database of the Max Planck Institute for Human Cognitive and Brain Sciences. Initial statistical analysis was performed between January 1 and March 31, 2021; the moderation analysis (results reported herein) was conducted between July 1 and July 31, 2022.ExposuresMothers reported postpartum mood via the German version of the Edinburgh Postnatal Depression Scale (higher scores indicated higher levels of depressed mood, with a cutoff of 13 points indicating a high probability of clinical depression) when their infants were 2 months old.Main Outcomes and MeasuresElectrophysiological correlates of infant speech perception (mismatch response to speech stimuli) were tested when the infants were aged 2 months (initial assessment) and 6.5 months (follow-up).ResultsA total of 46 mothers (mean [SD] age, 32.1 [3.8] years) and their 2-month-old children (mean [SD] age, 9.6 [1.2] weeks; 23 girls and 23 boys) participated at the initial assessment, and 36 mothers (mean [SD] age, 32.2 [4.1] years) and their then 6.5-month-old children (mean [SD] age, 28.4 [1.5 weeks; 18 girls and 18 boys) participated at follow-up. Moderation analyses revealed that more depressed maternal subclinical postpartum mood (mean [SD] Edinburgh Postnatal Depression Scale score, 4.8 [3.6]) was associated with weaker longitudinal changes of infants’ electrophysiological brain responses to syllable pitch speech information from ages 2 to 6.5 months (coefficient: 0.68; 95% CI, 0.03-1.33; P = .04).Conclusions and RelevanceThe results of this cohort study suggest that infant speech perception trajectories are correlated with subclinical depressed mood in postpartum mothers. This finding lays the groundwork for future research on early support for caregivers experiencing depressed mood to have a positive association with children’s language development.
Association of Drugs With Acute Angle Closure
Authors: Na Kyeong Ik , Park Sung Pyo 
Published: September 2022

ImportanceAcute angle-closure (AAC) glaucoma is a sight-threatening disease and can reportedly occur in association with various drugs.ObjectiveTo identify drugs that are associated with AAC glaucoma occurrence and evaluate the risk of AAC associated with each drug.Design, Setting, and ParticipantsA case-crossover study was conducted using the Health Insurance Review and Assessment Service database, which contains medical information of the entire Korean population. Patients who were first diagnosed with AAC and treated between 2013 and 2019 were identified using diagnostic and procedure codes. All drugs that the study participants were prescribed as well as prescription dates during the period of 1 to 180 days before the onset of AAC were extracted from the database. For each patient, 1 to 30 days before onset was considered the hazard period, and 91 to 180 days before AAC onset was considered the control period.Main Outcomes and MeasuresDrugs associated with AAC and odds (calculated as odds ratios [ORs] with 95% CIs) of AAC development associated with each identified drug.ResultsA total of 949 drugs that were prescribed to 13 531 patients with AAC (mean [SD] age, 66.8 [10.6] years; 9585 [70.8%] female) during the period of 1 to 180 days before the onset of AAC were analyzed. A total of 61 drugs were found to be associated with AAC, among which sumatriptan (OR, 12.60 [95% CI, 4.13-38.44]) was associated with the highest odds of AAC development, followed by topiramate (OR, 5.10 [95% CI, 2.22-11.70]) and duloxetine (OR, 4.04 [95% CI, 2.95-5.54]). The median (IQR) period from prescription of the drug to the onset of AAC for the 61 drugs was 11.9 days (10.9-12.8). A number of drugs not previously considered to be associated with AAC, including lactulose (OR, 2.81 [95% CI, 1.72-4.61]) and metoclopramide (OR, 2.52 [95% CI, 1.95-3.25]), were identified.Conclusions and RelevanceResults of this case-crossover study suggest a need to consider AAC risk in patients taking any of the 61 drugs found to be associated with AAC.
Mental health and wellbeing of seafaring personnel during COVID-19: Scoping review
Authors: Brooks Samantha K , Greenberg Neil 
Published: September 2022

Abstract

Objectives
We aimed to synthesize published literature on seafarers' mental health and wellbeing during the COVID-19 pandemic.

Methods
This scoping review searched four electronic databases for literature on the mental health and wellbeing of seafarers during the COVID-19 pandemic.

Results
Fourteen studies were included in the review. Few reported on the prevalence of mental health conditions. Only one compared mental health data gathered during the pandemic to pre-pandemic matched samples, suggesting symptoms of depression and anxiety were greater during the pandemic. There was some evidence that mental health worsened with longer stays on board during the pandemic and being on board longer than expected. Crew exchange difficulties forced many participants to extend their contracts or delay repatriation, often with little information as to when they might get to go home, leading them to feel they had no control over their lives and causing concern about fatigue and the potential for accidents and injuries. Participants described other challenges such as denial of shore leave; concerns about finances and future employment; loneliness and isolation; fears of COVID-19 infection; limited access to essential supplies; and feeling unsupported by management.

Conclusions
Maritime organizations must understand how best to support their staff in the aftermath of the COVID-19 pandemic and in any other prolonged crises that may arise in the future. Recommendations include ensuring that staff feel valued by their organization; enhancing work-related autonomy; ensuring that communication is accurate, consistent, and timely; and using lessons learned from the COVID-19 pandemic to inform emergency preparedness policies.
Adult‐onset dominant muscular dystrophy in Greek families caused by Annexin A11
Authors: Johari Mridul , Papadimas George , Papadopoulos Constantinos , Xirou Sophia , Kanavaki Aikaterini , Chrysanthou‐Piterou Margarita , Rusanen Salla , Savarese Marco , Hackman Peter , Udd Bjarne 
Published: September 2022

AbstractObjectiveMutations in the prion‐like domain of RNA binding proteins cause dysfunctional stress responses and associated aggregate pathology in patients with neurogenic and myopathic phenotypes. Recently, mutations in ANXA11 have been reported in patients with amyotrophic lateral sclerosis and multisystem proteinopathy. Here we studied families with an autosomal dominant muscle disease caused by ANXA11:c.118G > T;p.D40Y.MethodsWe performed deep phenotyping and exome sequencing of patients from four large Greek families, including seven affected individuals with progressive muscle disease but no family history of multi‐organ involvement or ALS.ResultsIn our study, all patients presented with an autosomal dominant muscular dystrophy without any Paget disease of bone nor signs of frontotemporal dementia or Parkinson's disease. Histopathological analysis showed rimmed vacuoles with annexin A11 accumulations. Electron microscopy analysis showed myofibrillar abnormalities with disorganization of the sarcomeric structure and Z‐disc dissolution, and subsarcolemmal autophagic material with myeloid formations. Molecular genetic analysis revealed ANXA11:c.118G > T;p.D40Y segregating with the phenotype.InterpretationAlthough the pathogenic mechanisms associated with p.D40Y mutation in the prion‐like domain of Annexin A11 need to be further clarified, our study provides robust and clear genetic evidence to support the expansion of the phenotypic spectrum of ANXA11.
Vapor‐Phase Growth Strategies of Fabricating Organic Crystals for Optoelectronic Applications
Authors: Xia Xing‐Yu , Ding Ling‐Yi , Lv Qiang , Wang Xue‐Dong , Liao Liang‐Sheng 
Published: September 2022

AbstractVapor‐phase growth methods, taking the advantages of producing high‐quality crystals with low defects, thin thickness, and homogeneous composition, are of great significance in the field of organic crystal growth and their high‐performance applications. At present, the requirements for organic crystals as building blocks for the construction of optoelectronic devices are increasing with the constant advances in organic optoelectronics. Therefore, the vapor‐phase growth method would become one of the practical techniques that cannot be ignored to fabricate organic crystals. In this paper, an overview of different vapor‐phase growth methods for the preparation of organic single crystals is provided. An introduction to the current status of the vapor phase method is presented and the view on the challenges it faces with some promising solution ideas. It is believed that this review will serve as a reference for further development and an inspiration for the new way forward.
(Under)valuing lived experience in the disability workforce: A snapshot of Australian job recruitment
Authors: Davies Kate , Butler Katie 
Published: September 2022

AbstractThe Australian disability workforce has grown, and there is compelling evidence that peer work has a number of valuable impacts. Despite these apparent opportunities, there continue to be high levels of unemployment among people with disability and failure to draw on the assets of people with disability in Australian workplaces. To understand these ostensible missed opportunities, this study examined the ways in which lived experience was described as an asset in disability workforce recruitment. Advertisements for positions in New South Wales, Australia, that referred to lived experience or peer work and disability were collected over a 3‐month period. Through a process of content analysis, we found that there were more employment opportunities for people with lived experience of mental illness than for other types of disability. Community engagement was a key function, and peer workers were described as complementary to professionals. Recruitment processes for lived experience jobs were not necessarily accessible. We recommend systemic reforms to facilitate recognition of lived experience as a valuable criterion for disability sector employment and to harness the benefits of a disability peer workforce.
Inhibition of the dopamine transporter promotes lysosome biogenesis and ameliorates Alzheimer's disease–like symptoms in mice
Authors: Yin Limin , Zhou Jianhui , Li Tianyou , Wang Xinghua , Xue Wenlong , Zhang Jie , Lin Lingxi , Wang Ning , Kang Xinyi , Zhou Yu , Liu Hong , Li Yang 
Published: September 2022

AbstractIntroductionLysosomes are degradative organelles that maintain cellular homeostasis and protein quality control. Transcription factor EB (TFEB)–mediated lysosome biogenesis enhances lysosome‐dependent degradation and alleviates neurodegenerative diseases, but the mechanisms underlying TFEB regulation and modification are still poorly understood.MethodsBy screening novel small‐molecule compounds, we identified a group of lysosome‐enhancing compounds (LYECs) that promote TFEB activation and lysosome biogenesis.ResultsOne of these compounds, LH2‐051, significantly inhibited the function of the dopamine transporter (DAT) and subsequently promoted lysosome biogenesis. We uncovered cyclin‐dependent kinase 9 (CDK9) as a novel regulator of DAT‐mediated lysosome biogenesis and identified six novel CDK9‐phosphorylated sites on TFEB. We observed that signal transduction by the DAT‐CDK9‐TFEB axis occurs on lysosomes. Finally, we found that LH2‐051 enhanced the degradation of amyloid beta plaques and improved the memory of amyloid precursor protein (APP)/Presenilin 1 (PS1) mice.DiscussionWe identified the DAT‐CDK9‐TFEB signaling axis as a novel regulator of lysosome biogenesis. Our study sheds light on the mechanisms of protein quality control under pathophysiological conditions.
Three‐dimensional numerical simulation on fiber orientation of short‐glass‐fiber‐reinforced polypropylene composite thin‐wall injection‐molded parts simultaneously accounting for wall slip effect and pressure dependence of viscosity
Authors: Jiang Qing‐song , Liu He‐sheng , Wang Xiao‐chun , Hu Zhi‐xin , Zhou Hai‐ying , Nie Hua‐rong 
Published: September 2022

AbstractOn account of the inherent features of the thin‐wall injection molding process, a three‐dimensional numerical model, which accounts for wall slip effect and pressure dependence of viscosity (PDoV), was proposed for a more accurate simulation of the fiber orientation in thin‐wall injection‐molded parts of short‐glass‐fiber‐reinforced polymer composites (SGFRPC). First, the fiber orientation was simulated using the three‐dimensional and mid‐plane models, respectively. The comparison between the simulated and experimental results verifies that the three‐dimensional numerical results were in better agreement with the experimental measurements. Secondly, the influences of wall slip effect and PDoV on fiber orientation in thin‐wall injection‐molded parts of SGFRPC were analyzed based on the three‐dimensional numerical model. The results show that the three‐dimensional numerical simulation simultaneously accounting for wall slip effect and PDoV can better predict the fiber orientation in thin‐wall injection‐molded parts of SGFRPC, suggesting the validation of the proposed model. Finally, five main processing parameters, that is, injection rate, melt temperature, mold temperature, packing pressure, and packing time, were also studied in terms of their influences on the fiber orientation in thin‐wall injection‐molded parts of SGFRPC.
A critical analysis of stalking theory and implications for research and practice
Authors: Parkhill Alice J. , Nixon Margaret , McEwan Troy E. 
Published: September 2022

AbstractThis article comprehensively reviews and critiques theories providing an aetiological account of stalking. We evaluate applications of preexisting psychological theories to stalking (attachment theory, evolutionary theory, social learning theory, information processing models of aggression, coercive control theory, and behavioural theory) as well as the only novel theory of stalking to date: Relational goal pursuit theory. Our aim was to identify which are supported by research, identify gaps in theoretical scope and explanatory depth and examine how current theories might inform clinical practice. This evaluation suggests that theories of stalking are underdeveloped relative to other areas of forensic clinical psychology and the theoretical literature is relatively stagnant. Consequently, there is limited research into clinically meaningful constructs that can guide the assessment, formulation and treatment of this client group. We identify similarities across existing theories, discussing implications for future research and clinical practice with people who stalk.
Phase I study of plitidepsin in combination with bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma
Authors: Mateos María Victoria , Prosper Felipe , Martin Sánchez Jesús , Ocio Enrique M. , Oriol Albert , Motlló Cristina , Michot Jean‐Marie , Jarque Isidro , Iglesias Rebeca , Solé María , Martínez Sara , Kahatt Carmen , Fudio Salvador , Corral Gema , Zeaiter Ali , Montilla Lola , Ribrag Vincent 
Published: September 2022

AbstractPrevious studies showed antitumor activity for plitidepsin plus dexamethasone (DXM) in relapsed/refractory multiple myeloma (r/r MM), and in vitro synergism with bortezomib (BTZ) or DXM against MM cells. This phase I trial evaluated plitidepsin (3‐h intravenous infusion Day 1 and 15), BTZ (subcutaneous bolus Day 1, 4, 8, and 11), and DXM (orally Day 1, 8, 15, and 22), every 4 weeks in 36 r/r MM patients. Twenty‐two patients were treated using a standard dose escalation design (10 at the recommended dose [RD] cohort), and 14 additional patients were treated to expand the RD cohort. No dose‐limiting toxicities (DLTs) occurred during dose escalation. The highest dose level evaluated (plitidepsin 5.0 mg/m2, BTZ 1.3 mg/m2, DXM 40.0 mg) was the RD for phase II studies. Results shown herein are focused on this RD. Two patients had DLTs (grade 3 diarrhea, and grade 3 nausea/vomiting refractory to antiemetic therapy). Grade ≥ 3 hematological toxicity (thrombocytopenia 46%, anemia 33%, and neutropenia 17%) was manageable and did not result in treatment discontinuation. Transient and manageable grade 3 ALT increase (26%) was the most common biochemical abnormality. At the RD cohort, overall response rate was 22.2% (95%CI, 6.4%–47.6%), including one stringent complete response, one very good partial response, and two partial responses in r/r patients to BTZ and/or lenalidomide. The clinical benefit rate was 77.8% (95%CI, 52.4–93.6%). No major pharmacokinetic drug–drug interaction was found. In conclusion, the triple combination of plitidepsin, BTZ, and DXM showed an acceptable safety profile and had moderate activity in adult patients with r/r MM.
Technology readiness level of gas hydrate technologies
Authors: Englezos Peter 
Published: September 2022

AbstractGas or clathrate hydrates are non‐stoichiometric crystalline materials known primarily for the operational and safety problems they pose during hydrocarbon processing as well as a potential source of unconventional natural gas. Gas hydrates also have a variety of other applications, mostly representing opportunities for technology development such as gas separations and seawater desalination. This dual nature of gas hydrates is best represented by the two faces of a Janus particle. Although the research on the various gas hydrate‐based technologies has been reviewed, the focus has been on the phase equilibrium and kinetic data needed for process design. On the other hand, the status of the technologies in terms of their commercialization has not been methodically assessed. In this work, we employ the nine‐level technology readiness level (TRL) tool to classify the various technologies that are based on gas hydrate crystallization. A brief review of the current status of the technologies is presented first, followed by the status of each one on the TRL scale.