bluuebunny/crossref_metadata_2025_split huggingface dataset:
Midwives’ empathy and shared decision making from women’s perspective - sensitivity of an assessment to compare quality of care in prenatal and obstetric care
Authors: Schulz Anja Alexandra , Wirtz Markus Antonius 
Published: September 2022

Abstract
Background
For quality-oriented evaluation of prenatal and obstetric care, it is important to systematically consider the perspective of the women receiving care in order to comprehensively assess and optimize quality in a woman-centered manner. Empathy and Shared Decision Making (SDM) are essential components of woman-centered midwifery care. The aim of the study was to analyze measurement invariance of the items of the Consultation and Relational Empathy (CARE) and Shared Decision Making-Questionnaire (SDM-Q-9) scales depending on the prenatal versus obstetric care setting.

Methods
One hundred fifty women retrospectively assessed aspects of woman-centered midwifery care in both prenatal and obstetric care setting. The birth of the child was a maximum of 12 months ago. A structural equation modelling approach was adopted to separate true effects from response shift (RS) effects depending on care setting. The latter were analyzed in terms of recalibration (changing women’s internal measurement standards), Reprioritization (changing associations of items and construct) as well as Reconceptualization (redefining the target construct).

Results
A response shift model was identified for both assessments (pregnancy/birth: CFI = .96/.96; SRMR = .046/.051). At birth, both scales indicated lower quality of care compared with prenatal care (SDM-Q-9-M/CARE-8-M:|d| = 0.190/0.392). Although no reconceptualization is required for the items of both scales, RS effects are evident for individual items. Due to recalibration and reprioritization effects, the true differences in the items are partly underestimated (SDM-Q-9-M/CARE-8-M: 3/2 items) or overestimated (4/2 items).

Conclusion
The structure of the constructs SDM and Empathy, indicating woman-centered midwifery care, are moderated by the care settings. To validly assess midwives’ empathy and shared decision making from women’s perspective, setting-dependent response shift effects have to be considered. The proven item-specific response effects contribute to a better understanding of construct characteristics in woman-centered care by midwives during pregnancy and childbirth.
2011–2021 rising prevalence of HPV infection among oropharyngeal carcinoma in France
Authors: Gorphe Philippe , Blanchard Pierre , Garcia Gabriel C. T. E. , Classe Marion , Even Caroline , Temam Stéphane , Breuskin Ingrid 
Published: September 2022

AbstractBackgroundThe objective of our study was to investigate changes over the past decade in patient age and the prevalence of HPV in the population of patients with oropharyngeal carcinoma (OPC) treated at our center.MethodsWe performed a retrospective cohort study of patients treated at our cancer center for OPC between 2011 and 2021. Tissue biopsies were assessed for HPV status based on p16 staining for all patients.ResultsThere were 1,365 treated patients. The proportion of p16-positive patients increased from 43% in 2011 to 57.3% in 2021 (p = 0.01). The sex ratio was 3.6 M/1F for p16-positive and 3.7 M/1F for p16-negative patients (p = 0.94). The mean age increased from 60.2 y in 2011 to 63.6 y in 2021. The mean ages were 61.9 y for p16-positive and 61.7 y for p16-negative patients (p = 0.71), but there was a broader age distribution for the p16-positive patients (p = 0.03). The proportion of patients older than 70 y increased from 11% in 2011 to 28.2% in 2021, and this aging was similar between p16-positive (30.7% in 2021) and p16-negative (26.3% in 2021) patients. The 2-year and 5-year OS rates were 73.7% and 56.5% for the entire cohort. p16-positive patients had 2-year and 5-year OS rates of 86.8% and 77.4%, respectively, whereas p16-negative patients had 2-year and 5-year OS rates of 63.9% and 40.5%.ConclusionsAssessment of the change over the past decade in the population of patients with OPC at our center showed that HPV-positive OPC now appear to have overtaken HPV-negative cases in France, with 57.3% in 2021, and showed significant aging, with almost thirty percent of patients now older than 70 years. Those combined changes emphasize some of the challenges to be addressed in future OPC management.
Understanding of black salve toxicity by multi-compound cytotoxicity assays
Authors: Croaker Andrew , Davis Arie , Carroll Anthony , Liu Lei , Myers Stephen P. 
Published: September 2022

Abstract
Background
Black salve is a controversial complementary and alternative medicine (CAM) associated with skin toxicity and skin cancer treatment failures. Black salve formulations vary between manufacturers and contain a number of botanical and synthetic constituents. The skin cancer cytotoxicity of a number of these constituents has not been assessed to date. The alkaloids from the rhizomes of Sanguinaria canadensis, a key black salve ingredient, have had their single compound cytotoxicity assessed; however, whether they possess synergistic cytotoxicity with other compounds has not been studied and is of direct clinical relevance. This research aimed to improve our understanding of the skin cancer cytotoxicity of black salve constituents.

Methods
The cytotoxicity of individual and combination black salve constituents were assessed against the A375 melanoma and A431 squamous cell carcinoma cell lines. Cytotoxicity was determined using the Resazurin assay with fluorescence measured using a Tecan Infinite 200 Pro Microplate reader, compound cytotoxicity being compared to that of the topical cancer therapeutic agent, 5- fluouracil. Docetaxal was used as a positive control. Dunnetts p value was used to determine whether significant synergistic cytotoxicity was present.

Results
Sanguinarine was the most cytotoxic compound tested with a 24-hour IC50 of 2.1 μM against the A375 Melanoma cell line and 3.14 μM against the A431 SCC cell line. All black salve constituents showed greater cytotoxicity against the two skin cancer cell lines tested than the skin cancer therapeutic 5-Fluouracil with 24 hours of compound exposure. Chelerythrine and minor Quaternary Benzophenanthridine Alkaloids (QBAs) present in black salve, at concentrations not having a cytotoxic effect by themselves, boosted the cytotoxic effects of sanguinarine. This could be a synergistic rather than additive cytotoxic effect although the synergistic effect was cell line and concentration dependent.

Conclusions
Black salve contains several cytotoxic compounds, a number of which have been found to possess synergistic cytotoxicity for the first time against skin cancer cell lines. In addition, these compounds together increase the overall cytotoxic effect. Assessing multi-compound cytotoxicity in herbal medicine can provide additional information about both their therapeutic and toxicity potential. As black salve is currently being used by patients, further cytotoxicity work should be undertaken to assess whether synergistic cytotoxicity exists when tested in normal skin cells.
STMN1 as a novel prognostic biomarker in HCC correlating with immune infiltrates and methylation
Authors: Zhang En-di , Li Chenxuan , Fang Yuan , Li Na , Xiao Zhongyun , Chen Chuhong , Wei Benkai , Wang Hangping , Xie Jincheng , Miao Yinglei , Zeng Zhong , Huang Hanfei 
Published: September 2022

Abstract
Background
Upregulation of Stathmin 1 (STMN1), a cytoplasmic phosphoprotein that controls the dynamics of cellular microtubules, is linked to malignant behavior and poor prognosis in a range of malignancies. However, little research has been done on STMN1’s potential role in HCC as a single factor in DNA methylation, m6A, or immunological modulation.

Results
STMN1 is overexpressed in hepatocellular carcinoma, where it is related to clinicopathological parameters and affects the prognosis of HCC patients. STMN1 overexpression plays an important role in the diagnosis and prognosis of hepatocellular carcinoma. Meanwhile, methylation of 7 CpG sites of STMN1 in HCC was correlated with prognosis, and STMN1 expression was closely related to m6A modification. In addition, STMN1 expression is associated with immune cell infiltration, immune molecules, and immune checkpoints in HCC.

Conclusion
STMN1 has a significant role in hepatocellular carcinoma diagnosis and prediction. STMN1 is implicated not just in the onset and course but also in the immunological modulation of the disease. DNA methylation and m6A are both linked to STMN1. Therefore, STMN1 could be used as a diagnostic and prognostic biomarker for HCC, as well as a target for immunotherapy.
Physical activity from young adulthood to middle age and premature cardiovascular disease events: a 30-year population-based cohort study
Authors: Nagata Jason M. , Vittinghoff Eric , Gabriel Kelley Pettee , Rana Jamal S. , Garber Andrea K. , Moran Andrew E. , Reis Jared P. , Lewis Cora E. , Sidney Stephen , Bibbins-Domingo Kirsten 
Published: September 2022

AbstractBackgroundAlthough physical activity is generally protective of cardiovascular disease (CVD), less is known about how young adult physical activity relates to premature CVD events. The objective of this study was to determine the association between level and change in physical activity from young adulthood to middle age and incidence of premature CVD events before age 60.MethodsWe analyzed data collected across four urban sites from nine visits over 30 years of follow-up (1985–2016) from the Coronary Artery Risk Development in Young Adults (CARDIA) study, a prospective community-based cohort study of 5115 Black and White women and men aged 18–30 years at baseline (1985–1986). Linear mixed models were used to develop individualized moderate-to-vigorous intensity self-reported physical activity trajectories per participant. Fatal and nonfatal coronary heart disease (CHD), heart failure, and stroke outcomes were analyzed separately and as a combined CVD event outcome.ResultsOverall, physical activity declined in young adults as they progressed through middle age. Lower physical activity scores (per 100 exercise units) in 18 year-olds were associated with higher odds of premature CHD (AOR 1.14, 95% CI 1.02–1.28), heart failure (AOR 1.21, 95% CI 1.05–1.38), stroke (AOR 1.20, 95% CI 1.04–1.39), and any CVD (AOR 1.15, 95% CI 1.06–1.24) events. Each additional annual 1-unit reduction in the physical activity score was associated with a higher annual odds of incident heart failure (1.07, 95% CI 1.02–1.13), stroke (1.06, 95% CI 1.00–1.13), and CVD (1.04, 95% CI 1.01–1.07) events. Meeting the minimum (AOR 0.74, 95% CI 0.0.57–0.96) and twice the minimum (AOR 0.55, 95% CI 0.34–0.91) Department of Health and Human Services physical activity guidelines through follow up was protective of premature CVD events.ConclusionsGiven recent trends in declining physical activity with age and associated premature CVD events, the transition from young adult to midlife is an important time period to promote physical activity.
Assessment of perceived risk and precautionary behavior toward COVID-19 pandemic using the health belief model, Saudi Arabia
Authors: Mortada Eman M. , Elhessewi Ghada Moh Samir 
Published: September 2022

Abstract
Background
The global threat of the COVID-19 pandemic continues to evolve forming the most impactful health crises in modern history, necessities of individuals adhering to mandatory behavior change that limits the spread of the pandemic. The purpose of the current study is to identify behavioral responses of the health sciences university students during the period of the COVID-19 pandemic and determine risk perceptions using the health belief model (HBM).

Methods
A cross-sectional study using an online survey distributed among health sciences female university students in Riyadh, KSA. The questionnaire was used to assess sociodemographic characteristics; knowledge about COVID-19 and its preventive measures, risk perceptions, and beliefs using the HBM; and their actual adoption of precautionary measures.

Results
The mean age of 286 respondents was 21.6 years (SD 2.5). They had good knowledge, positive risk perception, and good practice. Fifty-seven percent of the respondents adhere satisfactorily to COVID-19 precautionary behavior. Respondents with positive overall risk perception had around 6 times significantly higher adherence compared to those with negative risk perception. Perceived benefits have higher odds of adherence to COVID-19 precautionary behavior. Similarly, cues to action were a significant determinant of adherence to COVID-19 precautionary behavior.

Conclusions
The constructs of the HBM provided good measurement of risk perception and the respondent students had good knowledge. Yet, significant gaps were shown between COVID-19 perceived risks and the students’ actual practice of personal hygienic measures, particularly hand hygiene. To put an end to the present COVID-19 and its upcoming waves, it is highly recommended to direct COVID-19 training programs specifically tailored towards university students.
Four-channel parity-time symmetry
Authors: Özgün Ege , Ozbay Ekmel , Ozdur Ibrahim 
Published: September 2022

Abstract
In this letter, we propose a general scheme for four-channel parity-time symmetry. We theoretically demonstrate how to achieve novel features via exploiting the parity-time symmetry for four-channel coupled-mode equations and study the spontaneous symmetry breaking manifold, separating the parity-time symmetric and parity-time broken regimes, for various parameter configurations. We also propose a possible candidate (an optoelectronic oscillator) which can demonstrate the theoretically derived features, which include broadband tunability, eigenfrequency selection and flipping, and single/dual frequency operation regimes.
Utilization of Navigation-Integrated, Mixed Reality Templates for Minimizing Invasiveness of Neurosurgical Procedures: A Case Series
Authors: Jean Walter C. , Sack Kenneth D. 
Published: September 2022

BACKGROUND:
The tenets of minimally invasive neurosurgery require small craniotomies that nevertheless afford sufficient surgical freedom to safely accomplish the operative goal.

OBJECTIVE:
To present a novel technique which couples surgical rehearsal in virtual reality (VR) with navigation-integrated, microscope-synchronized augmented reality (AR) to optimize minimally invasive openings.

METHODS:
A retrospective review of the senior author's early experience with this mixed reality (VR + AR) platform was conducted. Patient-specific VR models were rendered from standard computed tomography/MRI. Surgical rehearsal with these models created templates with the optimal opening, which were integrated with the AR system. In surgery, the templates were projected through a navigation-tracked microscope and appeared as AR objects onto the patient. The templates guided the planning of the incision and steps of the approach.

RESULTS:
Sixteen patients were included in this study, 11 women and 5 men (33-79 years; median: 59.5). Twelve operations were performed for mass lesions and 4 for microvascular decompression for trigeminal neuralgia. There were no intraoperative adverse events related to AR. For 15 patients (94%), the templates provided major advantage in optimizing the bony opening and guided the operation to the specific anatomic location chosen preoperatively. For 1 patient, the AR template guided the drilling away from the critical structures inside the temporal bone. In addition, 3-dimensional AR markers relieve the surgeon from ergonomically cumbersome monitor-based navigation (Video 1).

CONCLUSION:
This novel mixed reality platform combines surgical rehearsal in VR and navigation-integrated, microscope-synchronized overlay of AR templates to ensure that optimal exposure is efficiently obtained.
Mapping health services for adults with cerebral palsy in Ireland: a pilot study
Authors: Manikandan Manjula , Jagdeo Shalini , Weldon Fiona , Harrington Sarah , O'Sullivan Rory , Fortune Jennifer , Kerr Claire , M Ryan Jennifer 
Published: September 2022

Background: Cerebral palsy (CP) is a common cause of physical disability in childhood. The majority of children with CP survive to adulthood. Once discharged from children’s services, adults with CP find it challenging to navigate health services. The aim of this study was to pilot and refine a methodology to map services for adults with CP in Ireland. Methods: We used a multi-informant mapping methodology consisting of: 1. Defining health services; 2. Identifying informants; 3. Designing a survey; 4. Collecting data; 5. Data checking and analysis. We collected data on services from service users and service providers using an online survey. We verified data against information available online and by asking organisations to provide details about the service. Results: Fifteen service users and nine service providers completed the online survey. Data on 265 unique services at 32 organisations were provided. The most commonly provided services were physiotherapy (12%) and occupational therapy (11%). We confirmed the name of 89 services (34%) against online information. We received further details from eight organisations about 27 services. Specifically, we received details about the organisation name for 27 of the 265 services (10%), service name for 25 services (9%), service type for 25 services (9%), a website for 19 services (7%), and data on eligibility criteria and types of supports provided for between 25 or 26 services (9% or 10%). Conclusion: This pilot study highlighted the complexity of mapping services for adults with CP in Ireland. Prior to conducting a future study, the scope of the map of services should be considered, and attempts should be made to improve the accuracy of information provided by informants and to engage organisations in verifying service details.
The possibility of spatial mapping of soil organic carbon content at three depths using easy-to-obtain ancillary data in a Mediterranean area
Authors: Blanco Velázquez Francisco José , Shahabi Mahmoud , Rezaei Hossein , González-Peñaloza Félix , Shahbazi Farzin , Anaya-Romero María 
Published: September 2022

Background: Unlike most of Europe, Andalucía in southern Spain as a Mediterranean area still lacks digital maps of soil organic carbon (SOC) content at multiple depths, which can be generated by machine learning algorithms. The wide diversity of climate, geology, hydrology, landscape, topography, vegetation, and micro-relief data as easy-to-obtain covariates has facilitated the development of digital soil mapping (DSM). The purpose of this research is to model and map the spatial distribution of SOC at three depths, in an area of approximately 10000 km2 located in Seville and Cordoba Provinces, and to use R programming to compare two machine learning techniques (cubist and random forest) for developing SOC maps at multiple depths. Methods: Environmental covariates used in this research include nine derivatives from digital elevation models (DEM), three climatic variables, and 18 remotely-sensed spectral data (band ratios calculated by Landsat-8 Operational Land Imager ‘OLI’ and Sentinel-2A Multispectral Instrument ‘MSI’ in July 2019). In total, 300 soil samples from 100 points at three depths (0-25 cm, 25-50 cm, and 50-75 cm) were taken from existing literature. Both machine learning techniques were compared taking into account their accuracy using the goodness-of-fit criteria to predict SOC. Results: The findings showed that integrating the indices derived by Landsat-8 OLI and Sentinel-2A MSI satellite data had a better result than when satellite data was used separately. Conclusions: We obtained evidence that the resolution of satellite images is a key parameter in modelling and digital mapping.
Manipulation and (Mis)trust in Prediction Markets
Authors: Choo Lawrence , Kaplan Todd R. , Zultan Ro’i 
Published: September 2022

Markets are increasingly used as information aggregation mechanisms to predict future events. If policymakers and managers use markets to guide policy and managerial decisions, interested parties may attempt to manipulate the market in order to influence decisions. We study experimentally the willingness of managers to base decisions on market information under the shadow of manipulation. We find that when there are manipulators in the market, managers under-utilize the information revealed in prices. Furthermore, mere suspicion of manipulation erodes trust in the market, leading to the implementation of suboptimal policies—even without actual manipulation. This paper was accepted by Yan Chen, behavioral economics and decision analysis.
A grounded theory on collaborative interactions in a community-university partnership: the case of youth in the public space
Authors: Dewaele Alexis , Anderson Lindsey , Klima Noel , Lauwerier Emelien 
Published: September 2022

Background:Research impact is at least partly generated through collaborative interactions, yet the associations between knowledge production and impact are far more complex than relatively simple linear models generally describe.
Aims and objectives:In this case study, we focus on a community-university partnership and try to answer the question, ‘What are the conditions that facilitate or hinder successful collaborative interactions aimed towards solving a shared challenge between partners from different organisations?’
Methods:A set of four co-creation sessions with diverse stakeholders was organised with the aim of tackling the nuisance caused by youth in a specific deprived neighbourhood in Belgium. The sessions were video-recorded, transcribed verbatim, and analysed following a Grounded Theory (GT) approach to develop theoretical understandings of the process of knowledge production and research impact.
Findings:Roles and mandates of individual stakeholder representatives determine (and hinder) their access to (confidential) information, but also their visibility and accessibility towards youth as end users. Achieving positive outcomes through collaboration was perceived by stakeholders as slowly evolving towards small successes, and was facilitated by being able to accept failure, working in a climate of trust, developing a shared identity, managing expectations, informally sharing information, and being able to connect with youth.
Discussion and conclusions:We reflect on the importance of overcoming organisational asymmetries in collaborative interactions through installing feedback loops, and through the particular roles of boundary organisations, boundary objects, and practical tools that can help steer iterative collaborative interactions towards positive impact.