bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post‐mating diclofenac vs. carprofen treatment on serum progesterone levels and reproductive outcomes inHungarian‐Merinoewes during the non‐breeding season
Authors: Kutlu Metehan , Doğan Halef , Alkan Hasan , Serbester Uğur , Kutlu Hasan Rüştü 
Published: August 2022

AbstractThe maternal recognition process is crucial for the establishment of healthy pregnancy. In this process, anti‐luteolytic applications are one of the main reproductive strategies to manage the embryonic losses and maximize reproductive profitability in farm animals. The aim of this study was to investigate the efficacy of post‐mating NSAID treatments on reproductive parameters (pregnancy rate, lambing rate, multiple birth rate, litter size) and serum progesterone levels in ewes stimulated with progesterone non‐breeding season. For this purpose, two different experiments (diclofenac and carprofen) were conducted in the same ewe flock induced with short‐term progestogen‐based protocol in the non‐breeding season for two consecutive years. In experiment 1 (n = 85), 42 ewes were injected with 2.5 mg/kg diclofenac on the 9th and 10th days post‐mating, and the rest were not treated and served as control. In experiment 2 (n = 82), 40 ewes were injected with 1.4 mg/kg carprofen on the 9th days post‐mating, and the rest were not treated as control. In both experiments, blood samples were collected from all ewes on days 9, 12 and 13 post‐mating to measure serum progesterone levels. In both experiments, there were no differences both reproductive parameters and serum progesterone levels when compared to the control groups. It was concluded that post‐mating diclofenac and carprofen treatments in the critical period have no significant effects on both reproductive parameters and serum progesterone levels in ewes in the non‐breeding season.
Antimicrobial stewardship in pediatric solid organ transplantation: Is it possible?
Authors: Kitano Taito , Allen Upton 
Published: August 2022

AbstractBackgroundSolid organ transplant (SOT) recipients are at increased risk of severe outcomes associated with antimicrobial resistance (AMR). Antimicrobial stewardship programs (ASPs) play a vital role in mitigating the negative impacts of AMR. Pediatric evidence regarding ASP for SOT recipients is scarce, although many pediatric SOT centers have implemented different forms of ASP.MethodsThis article summarized the available evidence relating to AMR among pediatric SOT recipients and discussed key strategies for the successful implementation of ASP among this population. The focus is primarily on antibacterial and secondarily on antifungal management.ResultsThe development of multidisciplinary antimicrobial stewardship teams for pediatric SOT recipients is essential for successful stewardship implementation. Key stakeholders may include but are not limited to SOT recipients and their caregivers, primary SOT teams (transplant physicians, transplant pharmacists, transplant unit nurses, and transplant outpatient care team), transplant surgery teams, transplant infectious diseases teams, hospital AST, microbiology teams, infection prevention teams, quality improvement teams, and information technology teams.ConclusionAs the evidence for optimal ASP in pediatric SOT is still evolving, it is important to measure the impact of implemented interventions.
Impact of antimetabolite discontinuation following cytomegalovirus or BK polyoma virus infection in kidney transplant recipients
Authors: Dubrawka Casey A. , Progar Kristin J. , January Spenser E. , Hagopian Jennifer C. , Nesselhauf Nicole M. , Malone Andrew F. 
Published: August 2022

AbstractBackgroundCytomegalovirus (CMV) and BK polyoma virus (BKV) infection following kidney transplantation have been associated with allograft dysfunction and allograft loss. Reduction in immunosuppression is a mainstay of management yet has been associated with increased risk of rejection. According to international consensus guidelines, one approach to management of these viral infections is to discontinue the antimetabolite. Little is known surrounding long‐term outcomes in these patients, and it remains unclear if consideration should be given to resuming the antimetabolite as variable re‐escalation strategies have been reported. The objective was to describe episodes of rejection and identify risk factors for rejection following antimetabolite withdrawal after CMV or BKV DNAemia in kidney transplant recipients.MethodsThis single‐center, retrospective review evaluated adult kidney transplant recipients with a serum CMV or BKV DNA PCR ≥500 copies/ml who underwent antimetabolite discontinuation. The primary outcome assessed was the incidence of biopsy‐proven acute rejection (BPAR).ResultsOne hundred fifty‐nine patients were included. Overall, 14 patients (8.8%) experienced BPAR at a median of 1.6 years after antimetabolite discontinuation. Compared to CMV, discontinuation after BKV DNAemia was associated with a higher incidence of BPAR. Characteristics observed more frequently in patients with BPAR included younger age, female sex, higher initial viral load, and development of de novo donor‐specific antibody (DSA).ConclusionThese findings suggest that antimetabolite discontinuation after CMV or BKV DNAemia in kidney transplant recipients is a reasonable and safe approach. Further prospective studies investigating optimal immunosuppression management following CMV or BKV DNAemia in kidney transplant recipients are warranted.image
Significant cost savings using a newly developed single‐process technology compared to conventional processes for treating high‐strength effluents
Authors: Hosseinlou Daniel 
Published: August 2022

AbstractThis study investigates the performance of a newly developed technology, known as simultaneous anaerobic oxidation/partial nitrification–denitrification (SAO/PND), for treating strong wastewater under laboratory conditions. Excellent results are achieved, with maximum chemical oxygen demand (COD) and nitrogen removal of 98% and 96%, respectively, when treating synthetic wastewater with influent 4120 mg/L COD and 210 mg/L NH4+–N. Appropriate living environment in this single‐process technology favoured the co‐existence of various bacterial communities, and removal mechanisms by these organisms are identified and confirmed. The results showed that the single‐process SAO/PND technology required 95% and 90% less oxygen compared to conventional aerobic processes and combined systems, respectively. Furthermore, this newly developed technology produced 60% and 44% less sludge, respectively, in comparison with the mentioned conventional systems. This study shows that the single‐process SAO/PND technology is a promising sustainable alternative to conventional systems, as it combines high efficiency and cost‐effectiveness with simple operation and maintenance requirements.
Insights into function of hydrocyclone separator and modified volcanic rock coagulant on formation of aerobic granular sludge
Authors: Zhao Qingyu , Guo Du , Guo Mingzhu , Li Yan , Zeng Ming , Wu Nan , Hao Linlin 
Published: August 2022

AbstractHydrocyclone separator and novel coagulants were adopted to separately enhance the granulating process of aerobic granular sludge. For hydrocyclone separator, although there was no obvious large particle, it was feasible to improve the sludge sedimentation capacity, indicated by the sludge volume index. Moreover, the nitrogen removal performance was promoted by the separator with a nitrogen removal rate of 8.2 mg/(L·h), nearly two times of system without a separator. Meanwhile, nitrogen‐related microbial communities were stimulated, for example, Thauera and Nitrosomonas. Another method of coagulation by the modified volcanic rock promoted the sludge settling performance. The optimum coagulating conditions were the coagulant size of 100 μm with dosage of 6 g/L. The addition of polyacrylamide played a weak role in granulation. Overall, the role of hydrocyclone separator and modified volcanic rock coagulant belonged to the improvement of the settleability of sludge and the aggregation of sludge, respectively.
Effectiveness of an intervention for reducing sitting time and improving health in office workers: three arm cluster randomised controlled trial
Authors: Edwardson Charlotte L , Biddle Stuart J H , Clemes Stacy A , Davies Melanie J , Dunstan David W , Eborall Helen , Granat Malcolm H , Gray Laura J , Healy Genevieve N , Jaicim Nishal Bhupendra , Lawton Sarah , Maylor Benjamin D , Munir Fehmidah , Richardson Gerry , Yates Thomas , Clarke-Cornwell Alexandra M 
Published: August 2022

AbstractObjectivesTo evaluate the effectiveness of an intervention, with and without a height adjustable desk, on daily sitting time, and to investigate the relative effectiveness of the two interventions, and the effectiveness of both interventions on physical behaviours and physical, biochemical, psychological, and work related health and performance outcomes.DesignCluster three arm randomised controlled trial with follow-up at three and 12 months.SettingLocal government councils in Leicester, Liverpool, and Greater Manchester, UK.Participants78 clusters including 756 desk based employees in defined offices, departments, or teams from two councils in Leicester, three in Greater Manchester, and one in Liverpool.InterventionsClusters were randomised to one of three conditions: the SMART Work and Life (SWAL) intervention, the SWAL intervention with a height adjustable desk (SWAL plus desk), or control (usual practice).Main outcomes measuresThe primary outcome measure was daily sitting time, assessed by accelerometry, at 12 month follow-up. Secondary outcomes were accelerometer assessed sitting, prolonged sitting, standing and stepping time, and physical activity calculated over any valid day, work hours, workdays, and non-workdays, self-reported lifestyle behaviours, musculoskeletal problems, cardiometabolic health markers, work related health and performance, fatigue, and psychological measures.ResultsMean age of participants was 44.7 years, 72.4% (n=547) were women, and 74.9% (n=566) were white. Daily sitting time at 12 months was significantly lower in the intervention groups (SWAL −22.2 min/day, 95% confidence interval −38.8 to −5.7 min/day, P=0.003; SWAL plus desk −63.7 min/day, −80.1 to −47.4 min/day, P<0.001) compared with the control group. The SWAL plus desk intervention was found to be more effective than SWAL at changing sitting time (−41.7 min/day, −56.3 to −27.0 min/day, P<0.001). Favourable differences in sitting and prolonged sitting time at three and 12 month follow-ups for both intervention groups and for standing time for the SWAL plus desk group were observed during work hours and on workdays. Both intervention groups were associated with small improvements in stress, wellbeing, and vigour, and the SWAL plus desk group was associated with improvements in pain in the lower extremity, social norms for sitting and standing at work, and support.ConclusionsBoth SWAL and SWAL plus desk were associated with a reduction in sitting time, although the addition of a height adjustable desk was found to be threefold more effective.Trial registrationISRCTN RegistryISRCTN11618007.
More than just oral PrEP: exploring interest in rectal douche, dissolvable implant, removable implant and injection HIV prevention approaches among racially diverse men who have sex with men in the Northeast Corridor
Authors: Martinez Omar , Levine Ethan , Munoz-Laboy Miguel , Carballo-Diéguez Alex , Bauermeister José Arturo , Chacon Alexi , Jacobson Jeffrey , Bettiker Robert , Sutton Madeline , Rudolph Abby E , Wu Elwin , Rhodes Scott D , Tanner Amanda E , Mann Lilli , Valentin Omar , Ilarraza Ariel , Pardes Mariana , Davison Robin , Fernandez Maria Isabel 
Published: August 2022

ObjectivesHIV scholars and practitioners have worked to expand strategies for prevention among marginalised populations who are disproportionately impacted by the epidemic, such as racial minority men who have sex with men (MSM). Given this urgency, the objective of this study was to assess interest in biomedical prevention strategies.MethodsThis exploratory and cross-sectional study investigated interest in four biomedical prevention tools—rectal douche, dissolvable implant, removable implant and injection—among a racially diverse sample of MSM from the Northeast Corridor region between Philadelphia and Trenton. Data were collected as part of screening for Connecting Latinos en Pareja, a couples-based HIV prevention intervention for Latino MSM and their partners.ResultsA total of 381 individuals participated in the screener and provided information about their interest in bio tools. Approximately 26% of participants identified as black, 28% as white and 42% as ‘other’ or multiracial; 49% identified as Latino. Majority (54%) reported some form of child sexual abuse. Of the participants who reported being in a primary relationship (n=217), two-thirds reported unprotected anal sex within that relationship over the past 90 days (n=138, 64%) and approximately half (n=117, 54%) reported unprotected anal sex outside of the relationship in this period. Majority of participants reported interest in all bio tools assessed, including dissolvable implants (60%), removable implants (64%), rectal douching (79%) and injection (79%). Although interest in bio tools was broadly unassociated with demographics and sexual risk behaviours, analyses revealed significant associations between reports of child sexual abuse and interest in implant and injection methods.ConclusionsThe authors recommend investing in these prevention methods, particularly rectal douching and injection, as a means of preventing HIV among racial minority MSM. Given the interest in biomedical prevention tools, future studies should explore potential strategies for adherence.
Heart rate, oxygen uptake, and energy expenditure response of an SL3 class parabadminton athlete to a progressive test and simulated training session: a case study
Authors: Oliveira Saulo F.M. , Oliveira José Igor V. , Haiachi Marcelo , Felder Hanno 
Published: August 2022

This investigation demonstrated a routine of evaluation and training of an athlete of the SL3 class of parabadminton for 2 days continuously monitored by a metabolic analyzer with measurements of oxygen consumption (V̇O2), carbon dioxide production, and heart rate (HR). The results showed HR and V̇O2 responses varying between 50% and 99.54% of HRmax (mean HR 80.92 bpm), and 6% and 104% (mean V̇O2 35.25 mL/kg/min) of V̇O2max, during the simulated game. The exercise test and the simulated training session showed significant changes in HR and V̇O2, reinforcing the need for considerable energy input to training and assessment.
Faddeev fixed-center approximation to the $$D\bar{D}K$$ system and the hidden charm $$K_{c\bar{c}}(4180)$$ state
Authors: Wei Xiang , Shen Qing-Hua , Xie Ju-Jun 
Published: August 2022

AbstractWe perform a theoretical study on the $$D\bar{D}K$$

D

D

¯

K

three body system, using the fixed center approximation to the Faddeev equations, considering the interaction between D and K, D and $$\bar{D}$$

D

¯

from the chiral unitary approach. We assume the scattering of K meson on a clusterized system $$D\bar{D}$$

D

D

¯

, where a scalar meson X(3720) could be formed. Thanks to the strong DK interaction, where the scalar $$D^*_{s0}(2317)$$

D

s
0

∗

(
2317
)

meson is dynamically generated, a resonance structure shows up in the modulus squared of the three body K-$$(D\bar{D})_{X(3720)}$$

(
D

D

¯

)

X
(
3720
)

scattering amplitude and supports that a $$D\bar{D}K$$

D

D

¯

K

bound state can be formed. The result is in agreement with previous theoretical studies, which claim a new excited hidden charm K meson, $$K_{c\bar{c}}(4180)$$

K

c

c

¯

(
4180
)

with quantum numbers $$I(J^P) = \frac{1}{2}(0^-)$$

I

(

J
P

)

=

1
2

(

0
-

)

and mass about 4180 MeV. It is expected that these theoretical results motivate its search in experimental measurements.
Medium modification of the nucleon mechanical properties: Abel tomography case
Authors: Kim June-Young , Yakhshiev Ulugbek , Kim Hyun-Chul 
Published: August 2022

AbstractWe investigate how the gravitational form factors of the nucleon undergo changes in nuclear matter, emphasizing the Abel transformation from the three-dimensional (3D) Breit frame to the two-dimensional (2D) light-front frame. Since the gravitational form factors reveal the mechanical structure of the nucleon, we examine also the medium modifications of the energy–momentum, pressure, and shear-force distributions. We scrutinize the stabilities of the nucleon in nuclear matter. For this purpose, we employ the in-medium modified SU(2) Skyrme model to study these mechanical quantities of the nucleon, since it provides a simple but clear framework. In this in-medium modified SU(2) Skyrme model, the modification of pionic properties is performed by using low-energy pion-nucleus scattering data and the saturation properties of nuclear matter near the normal nuclear matter density, $$\rho _0=0.5m_\pi ^3$$

ρ
0

=
0.5

m
π
3

. The results reveal how the nucleon swells in nuclear matter as the mass distribution of the nucleon is broadened in medium. We also show that the mean square radii corresponding to the mass and angular momentum distributions increase in nuclear medium. This feature is kept both in 3D and 2D cases. We visualize how the strong force fields inside the nucleon in the 2D plane are distributed and illustrate how these forces undergo change in nuclear matter.
Modified dispersion relations and a potential explanation of the EDGES anomaly
Authors: Das Saurya , Fridman Mitja , Lambiase Gaetano , Stabile Antonio , Vagenas Elias C. 
Published: August 2022

AbstractThe Experiment to Detect the Global Epoch of Reionisation Signature (EDGES) collaboration has recently reported an important result related to the absorption signal in the Cosmic Microwave Background radiation spectrum. This signal corresponds to the red-shifted 21-cm line at $$z \simeq 17.2$$

z
≃
17.2

, whose amplitude is about twice the expected value. This represents a deviation of approximately $$3.8\sigma $$

3.8
σ

from the predictions of the standard model of cosmology, i.e. the $$\Lambda $$
Λ
CDM model. This opens a window for testing new physics beyond both the standard model of particle physics and the $$\Lambda $$
Λ
CDM model. In this work, we explore the possibility of explaining the EDGES anomaly in terms of modified dispersion relations. The latter are typically induced in unified theories and theories of quantum gravity, such as String/M-theories and Loop Quantum Gravity. These modified dispersion relations affect the density of states per unit volume and thus the thermal spectrum of the Cosmic Microwave Background photons. The temperature of the 21-cm brightness temperature is modified accordingly giving a potential explanation of the EDGES anomaly.
An explanation of experimental data of $$(g-2)_{e,\mu }$$ in 3-3-1 models with inverse seesaw neutrinos
Authors: Hue L. T. , Phan Khiem Hong , Nguyen T. Phong , Long H. N. , Hung H. T. 
Published: August 2022

AbstractWe show that the anomalous magnetic moment experimental data of muon and electron$$(g-2)_{\mu ,e}$$(g-2)μ,ecan be explained simultaneously in simple extensions of the 3-3-1 models consisting of new heavy neutrinos and a singly charged Higgs boson. The heavy neutrinos generate active neutrino masses and mixing through the general seesaw mechanism. They also have non-zero Yukawa couplings with singly charged Higgs bosons and right-handed charged leptons, which result in large one-loop contributions known aschirally-enhancedones. Numerical investigation confirms a conclusion indicated previously that these contributions are the key point to explain the large$$(g-2)_{\mu ,e}$$(g-2)μ,edata, provided that the inverse seesaw mechanism is necessary to allow both conditions that heavy neutrino masses are above few hundred GeV and non-unitary part of the active neutrino mixing matrix must be large enough.
Structural and Visual Changes in Branch Retinal Vein Occlusion Patients with Retinal Atrophy
Authors: Li Zhenping , Gu Xiaoya , Song Shuang , Yu Xiaobing , Zhang Peng , Dai Hong 
Published: August 2022

Background. To study the changes of retinal vascular density (VD), retinal thickness (RT), and their correlations with visual acuity (VA) in branch retinal vein occlusion (BRVO) patients with retinal atrophy after resolution of macular oedema (MO). Methods. This is a retrospective study consisting of 46 patients diagnosed with BRVO at Beijing Hospital from 2015 to 2019. Patients’ 46 affected eyes and 39 fellow eyes were included. The affected eyes were further divided into the atrophy group and the nonatrophy group. Optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) images obtained when MO completely resolved after treatment with ranibizumab were analyzed. We quantitatively measured foveal avascular zone (FAZ) parameters, the disruption extent of ellipsoid zone (EZ), RT, and VD of superficial vascular complex (SVC), and deep vascular complex (DVC) in central fovea and the minimal-VD quadrant. Paired t-tests, independent t-tests, Mann–Whitney U tests, Wilcoxon tests, Pearson correlation analyses, Spearman correlation analyses, and single and multiple linear regression models were adopted. Results. Compared with nonatrophy eyes, the minimal-VD quadrantal (quadrantal for short) SVC-VD (25.76 ± 4.57% versus 36.21 ± 6.47%,

P
<
0.001

) and quadrantal DVC-VD (27.72 (17.23) % versus 38.95 (11.05) %,

P
=
0.001

) of atrophy eyes decreased significantly. Quadrantal SVC-VD and quadrantal DVC-VD were strongly correlated with quadrantal full RT (r = 0.763 and 0.698, both

P
<
0.001

). The disruption length of EZ was significantly correlated with quadrantal full RT (r = −0.406,

P
=
0.005

) and quadrantal SVC-VD (r = −0.298,

P
=
0.044

). In multiple linear regression analysis, the disruption length of EZ and VA before treatment and age showed significant correlations with VA with complete resolution of MO (

P
=
0.020
,

0.033
,
and
0.002

). Conclusions. The retinal VD on the affected area correlates well with the corresponding full RT when BRVO-MO completely resolves, suggesting that VD may predict the final RT. Severe decrease in VD may result in retinal atrophy, which may cause VA loss indirectly with the intermediate influencing factor of EZ defects.