bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adherence to the Dutch Breast Cancer Guidelines for Surveillance in Breast Cancer Survivors: Real-World Data from a Pooled Multicenter Analysis
Authors: Draeger Teresa , Voelkel Vinzenz , Schreuder Kay , Veltman Jeroen , Dassen Anneriet , Strobbe Luc , Heijmans Harald J , Koelemij Ron , Groothuis-Oudshoorn Catharina G M , Siesling Sabine 
Published: August 2022

Abstract

Background
Regular follow-up after treatment for breast cancer is crucial to detect potential recurrences and second contralateral breast cancer in an early stage. However, information about follow-up patterns in the Netherlands is scarce.

Patients and Methods
Details concerning diagnostic procedures and policlinic visits in the first 5 years following a breast cancer diagnosis were gathered between 2009 and 2019 for 9916 patients from 4 large Dutch hospitals. This information was used to analyze the adherence of breast cancer surveillance to guidelines in the Netherlands. Multivariable logistic regression was used to relate the average number of a patient’s imaging procedures to their demographics, tumor–treatment characteristics, and individual locoregional recurrence risk (LRR), estimated by a risk-prediction tool, called INFLUENCE.

Results
The average number of policlinic contacts per patient decreased from 4.4 in the first to 2.0 in the fifth follow-up year. In each of the 5 follow-up years, the share of patients without imaging procedures was relatively high, ranging between 31.4% and 33.6%. Observed guidelines deviations were highly significant (P &lt; .001). A higher age, lower UICC stage, and having undergone radio- or chemotherapy were significantly associated with a higher chance of receiving an imaging procedure. The estimated average LRR-risk was 3.5% in patients without any follow-up imaging compared with 2.3% in patients with the recommended number of 5 imagings.

Conclusion
Compared to guidelines, more policlinic visits were made, although at inadequate intervals, and fewer imaging procedures were performed. The frequency of imaging procedures did not correlate with the patients’ individual risk profiles for LRR.
COVID-19 and Corporate Finance
Authors: Pagano Marco , Zechner Josef 
Published: August 2022

Abstract
We distill evidence about the effects of COVID-19 on companies. Stock price reactions to the shock differed greatly across firms, depending on their resilience to social distancing, financial flexibility, and corporate culture. The same characteristics affected the response of firms’ sales, employment, and asset growth. Despite the shock, firms expanded their balance sheets and liquidity by raising funds from banks, bonds, and equity markets. While listed firms reduced their leverage, unlisted ones, especially small and medium enterprises, increased it. Government support programs helped firms access external funding. We conclude by identifying unexplored research issues regarding the long-run effects of COVID-19 on companies. (JEL: G11, G12, G13, G21, G24, G28, G32, G33, G35, G38, H81, H84)
Benchmarking Intensity
Authors: Pavlova Anna , Sikorskaya Taisiya 
Published: August 2022

AbstractBenchmarking incentivizes fund managers to invest a fraction of their funds’ assets in their benchmark indexes, and such demand is inelastic. We construct a measure of inelastic demand a stock attracts, benchmarking intensity (BMI), computed as its cumulative weight in all benchmarks, weighted by assets following each benchmark. Exploiting the Russell 1000/2000 cutoff, we show that changes in stocks’ BMIs instrument for changes in ownership of benchmarked investors. The resultant demand elasticities are low. We document that both active and passive fund managers buy additions to their benchmarks and sell deletions. Finally, an increase in BMI lowers future stock returns.Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
The Emergent Power of Human Cellular vs Mouse Models in Translational Hair Research
Authors: Castro Ana Rita , Portinha Carlos , Logarinho Elsa 
Published: August 2022

Abstract
Different animal models have been used for hair research and regeneration studies based on the similarities between animal and human skins. Primary knowledge on hair follicle (HF) biology has arisen from research using mouse models baring spontaneous or genetically engineered mutations. These studies have been crucial for the discovery of genes underlying human hair cycle control and hair loss disorders. Yet, researchers have become increasingly aware that there are distinct architectural and cellular features between the mouse and human HFs, which might limit the translation of findings in the mouse models. Thus, it is enticing to reason that the spotlight on mouse models and the unwillingness to adapt to the human archetype have been hampering the emergence of the long-awaited human hair loss cure. Here, we provide an overview of the major limitations of the mainstream mouse models for human hair loss research, and we underpin a future course of action using human cell bioengineered models and the emergent artificial intelligence.
Enforcement of security rights over seagoing ships, aircraft, and trains in international treaties
Authors: Keijser Thomas , van der Linden van Sprankhuizen Feben 
Published: August 2022

Abstract
This article focuses on the enforcement of security rights over seagoing ships, aircraft, and trains in several international treaties. It contains a largely chronological overview of the relevant international instruments and their scope of application. In addition, this contribution addresses both the conflict-of-laws provisions and the substantive law provisions on the enforcement remedies at the secured creditor's disposal, including procedural aspects of enforcement such as notice requirements, the conditions for a purchaser to obtain ‘clean title’, and de- and reregistration. The comparison of existing rules offers insights for further alignment of the international legal framework for the enforcement of security rights over seagoing ships, aircraft, and trains.
Early Change in Lower Limb Strength and Function in Lung Transplant Patients After Center-Based and Telerehabilitation
Authors: Wickerson Lisa , Rozenberg Dmitry , Singer Lianne G. , Mathur Sunita 
Published: August 2022

Purpose:
The aim of this study was to examine the change and relationship among quadriceps torque (QT) and physical function in adult lung transplant (LTx) patients undergoing rehabilitation.

Methods:
A prospective study assessed 6-min walk test (6MWT) distance, QT, and Short Physical Performance Battery (SPPB) at the start of pre-habilitation and 10-12 wk post-LTx. Functional outcomes were examined for within-group differences for participants who completed center-based rehabilitation between September 2019 and March 2020 and participants who completed telerehabilitation (“telerehab”) between March 2020 and June 2021 during COVID-19. Relationships between QT, SPPB, and 6MWT were examined pre- and post-LTx.

Results:
A total of 49 LTx recipients were included (30 men, 61 [56-67] yr, 26 center-based rehab, and 23 telerehab). The 6MWT increased (median 75 m: 95% CI, 35 – 117, P < .0001), and the telerehab group showed an LTx decrease in QT (−9.6 Nm: 95% CI, −29 to −2.3, P = .02) and an increased gait speed (0.21 m/sec: 95% CI, 0.11 – 0.47, P < .0001). Pre-LTx QT showed a moderate correlation to pre-LTx SPPB (r = 0.41, P = .004) and weak correlations to gait speed and 6MWT (r ranging from 0.21 to 0.35, P < .05). Post-LTx QT showed moderate correlations to post-LTx SPPB (r = 0.43, P = .002), gait speed (r = 0.54, P < .001), five-time sit-to-stand (r =−0.57, P < .0001), and 6MWT (r = 0.62, P < .0001).

Conclusions:
Early post-LTx 6MWT and gait speed increased with no improvement in QT or other SPPB components. Correlations between QT and measures of exercise capacity and lower limb function were stronger post-LTx. Serial measurements may further inform functional trajectories and rehabilitation models.
STRUCTURAL OUTCOME AFTER SURGERY FOR STAGE 5 RETINOPATHY OF PREMATURITY BASED ON THE NEW INTERNATIONAL CLASSIFICATION
Authors: Mano Fukutaro , Iwahashi Chiharu , Kuniyoshi Kazuki , Kusaka Shunji 
Published: August 2022

Purpose:
This study investigated the outcomes of vitrectomy for Stage 5 retinopathy of prematurity (ROP) based on the International Classification of Retinopathy of Prematurity third edition, in which Stage 5 ROP is divided into three subgroups.

Methods:
Fifty-four eyes of 34 patients with Stage 5 ROP who underwent vitrectomy between 2004 and 2020 were retrospectively analyzed. Data including sex, gestational age and weight at birth, International Classification of Retinopathy of Prematurity 3 subcategories, perioperative use of intravitreal bevacizumab injection and laser photocoagulation, surgical procedure and complications, final retinal reattachment, and follow-up period were collected.

Results:
Complete retinal reattachment was achieved in 16 eyes (88.9%) with Stage 5A and 13 eyes (39.4%) with Stage 5B (P = 0.0003, Wilcoxon rank-sum test). Three patients with Stage 5C were considered inoperable. Postoperative anatomical failure was significantly associated with stage (Stage 5B vs. 5A; odds ratio, 17.986; 95% confidence interval, 3.712–148.502; P = 0.0001, multivariate logistic regression analysis). Intraoperative intravitreal bevacizumab was significantly associated with lower postoperative incidence of vitreous hemorrhage and glaucoma (P = 0.041, chi-square test).

Conclusion:
Staging of preoperative anatomical features based on International Classification of Retinopathy of Prematurity 3 is a useful predictor for final anatomical success. Intraoperative intravitreal bevacizumab might reduce postoperative complication risks.
LOCATIONAL AGREEMENT OF NEAR-INFRARED AUTOFLUORESCENCE WITH CHOROIDAL VASCULAR HYPERPERMEABILITY IN CENTRAL SEROUS CHORIORETINOPATHY
Authors: Azuma Keiko , Nomura Yoko , Kitamoto Kohdai , Hashimoto Yohei , Fujino Ryosuke , Ueda Kohei , Inoue Tatsuya , Obata Ryo 
Published: August 2022

Purpose:
To characterize the findings of eyes with choroidal vascular hyperpermeability (CVH), a hallmark of central serous chorioretinopathy, using multimodal imaging and investigate the locational agreement between these findings and CVH.

Methods:
Among patients with central serous chorioretinopathy in either eye, eyes with CVH identified using indocyanine green angiography without exudative changes were included. All eyes were examined using funduscopy, fluorescein angiography, spectral-domain optical coherence tomography, and short-wavelength or near-infrared autofluorescence (SWAF or NIRAF). The locational agreement between CVH and imaging findings was evaluated for each modality. The relative index on how they overlapped was calculated as the overlapping index. Binarized images, particularly for NIRAF, were also evaluated.

Results:
This study included 69 CVH sites in 33 eyes of 28 patients. Pachydrusen was detected in 36% of CVH sites. Fluorescein angiography revealed hyperfluorescent areas in 39% of CVH sites. Optical coherence tomography findings identified 65% of CVH sites, but the overlapping index was 5%. Short-wavelength or near-infrared autofluorescence imaging identified 89% of CVH sites, but they exhibited variable autofluorescence. NIRAF imaging revealed hypoautofluorescence findings in all CVH sites. When binarized, near-infrared autofluorescent dark dots were observed in all CVH sites. Overlapping indices before and after binarization were 78% and 98%, respectively. The near-infrared autofluorescent dark dots area corresponded well with that of CVH (intraclass correlation coefficient, 0.987 [95% confidence interval, 0.952–0.995]).

Conclusion:
Hypoautofluorescent findings revealed on NIRAF imaging, especially after binarization processing, corresponded well with CVH sites. These multimodal imaging results may help investigate the anatomical or locational characteristics of CVH in patients with central serous chorioretinopathy.
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY CHARACTERIZATION OF EVOLVING LESIONS IN FELLOW EYES OF EXUDATIVE TYPE 3 MACULAR NEOVASCULARIZATION PATIENTS
Authors: Sacconi Riccardo , Forte Paolo , Capuano Vittorio , Miere Alexandra , Costanzo Eliana , Tombolini Beatrice , Fantaguzzi Federico , Jung Camille , Parravano Mariacristina , Varano Monica , Souied Eric , Bandello Francesco , Querques Giuseppe 
Published: August 2022

Purpose:
To investigate fellow eyes of newly diagnosed unilateral exudative Type 3 (T3) macular neovascularization (MNV) patients by assessing the presence and progression of a preclinical neovascular component during a 3-year follow-up.

Methods:
This is a longitudinal study involving three retinal referral centers. Patients affected by unilateral exudative treatment-naive T3 MNV were enrolled.

Results:
Twenty-four eyes of 24 patients (79 ± 6 years old) were enrolled. Nine eyes (37%) displayed a nonexudative T3 MNV at baseline that developed exudation after a mean of 9 ± 9 months. Fifteen eyes that did not display a nonexudative Type 3 MNV at baseline. Five eyes (21%) did not display neovessels at baseline, but showed a nonexudative T3 after 13 ± 9 months, and exudation after 8 ± 3 months. Five eyes (21%) developed active exudative T3 MNV after 23 ± 9 months, with no detectable nonexudative stage at baseline. Five eyes (21%) did not show MNV, but progressed to geographic atrophy by 36 months of follow-up. Overall, T3 MNV in the fellow eye accounted for 79%, all developing exudation over 3 years of follow-up.

Conclusion:
The occurrence of a nonexudative T3 MNV is a frequent event in the fellow eye of patients newly diagnosed with unilateral exudative T3 MNV and it precedes the development of exudation over 3 years (prevalence of 37% and cumulative incidence of 79%). Optical coherence tomography angiography approach may be used to perform an early diagnosis and treatment of patients with T3 MNV.
Rare Case of Neuroendocrine Tumor of Common Bile Duct Identified With Somatostatin Receptor But Not With Glucose Transporter Imaging
Authors: Mohite Ashish , Shukla Varun , M V Manikandan , Chowdhury Zachariah , Chaturvedi Meenakshi 
Published: August 2022

Abstract
Neuroendocrine tumors (NETs) are heterogeneous group of tumors arising from enterochromaffin cells. Neuroendocrine tumors are most commonly found in bowel and pancreatic tissue. Because of paucity of enterochromaffin cells in biliary tract, NETs of bile duct are very rare. Most of the neoplasms in the extrahepatic bile duct are adenocarcinomas; only 0.2% to 0.3% of NETs arise from the bile duct. Cases reported in the literature of biliary carcinoid are diagnosed postoperatively on histopathologic evaluation. We hereby demonstrate a rare presentation of CBD NET identified preoperatively on somatostatin receptor but not on glucose transporter imaging, confirmed by histopathology and immunohistochemistry to be grade 2 NET (Ki-67, 20%).
FDG PET/CT in Isolated Nasal Cavity Metastasis From Squamous Cell Lung Cancer
Authors: Zhang Jun , Dong Aisheng , Wang Yang 
Published: August 2022

Abstract
Nasal cavity metastasis is rare. We present FDG PET/CT findings in a case with isolated nasal cavity metastasis from squamous cell lung cancer. The nasal cavity tumor invaded the nasal septum and hard palate and showed intense inhomogeneous activity, mimicking a primary malignancy. Knowledge of the atypical manifestations of metastatic lung cancer will be helpful for correct diagnosis.
68Ga-FAPI PET/CT Detected Non–PSMA/FDG-Avid Primary Tumor in De Novo Metastatic Prostate Cancer
Authors: Pang Yizhen , Meng Tinghua , Xu Weizhi , Shang Qihang , Chen Haojun 
Published: August 2022

Abstract

68Ga-labeled PET tracer targeting PSMA is a promising diagnostic approach for staging and restating of prostate cancer (PCa), but cases with clinically relevant PCa and false-negative PSMA PET/CT have been reported. In this case, we reported 68Ga-PSMA, 18F-FDG, and 68Ga-FAPI PET/CT findings in a 65-year-old man with de novo metastatic PCa. 68Ga-FAPI PET/CT detected non–PSMA/FDG-avid primary PCa, consisting with multiparametric MRI findings. The subsequent histopathologic examination confirmed a Gleason 4 + 5 PCa. This case highlighted that 68Ga-FAPI PET/CT may be a useful imaging modality for primary PCa detection and localization.
Comparison of Internal Dosimetry of 18F-PSMA-1007 and 68Ga-PSMA-11-HBED-CC
Authors: Sharma Priya , Watts Ankit , Singh Harmandeep 
Published: August 2022

Background
Prostate cancer (PCa) is the most common cancer in men worldwide. Targeting prostate-specific membrane antigen (PSMA) using radiopharmaceuticals has shown promising results for PCa imaging as well as theranostics. 68Ga-based PSMA imaging is limited by production of small quantities by generator, and it has led to quest for cyclotron produced 18F-based PSMA ligands. In the current study, we evaluated the biodistribution and internal dosimetry of 18F-PSMA-1007 and compared it with 68Ga-PSMA-11-HBED-CC.

Materials and Methods
A total of 8 patients with histopathologically proven PCa were included in the study, of whom 4 patients underwent 18F-PSMA-1007, and the other 4 patients underwent 68Ga-PSMA-11-HBED-CC PET/CT. The biodistribution of both tracers was quantified for different organs by computing SUVs. All the patients underwent 5-point serial imaging to compute equivalent dose to essential organs and whole-body effective dose using OLINDA-based dosimetry.

Results
The radiotracer uptake in brain, lacrimal gland, salivary gland, heart, lung, liver, gallbladder, spleen, pancreas, intestine, gluteal muscle, and bone marrow were found to be higher in 18F-PSMA-1007 PET as compared with 68Ga PSMA-11 PET. Kidney and urinary bladder showed higher SUV value on 68Ga-PSMA-11-HBED-CC as compared with 18F-PSMA-1007.
The whole-body effective dose from 18F-PSMA-1007 (1.46E−02 mSv/MBq) was higher than 68Ga-PSMA-11-HBED-CC (1.03E−02 mSv/MBq). The highest mean equivalent dose from 18F-PSMA-1007 was observed in the kidneys (1.48E−01 mGy/MBq), followed by spleen (mean, 1.06E−01 mGy/MBq) and liver (6.80E−02 mGy/MBq), whereas 68Ga-PSMA-11-HBED-CC equivalent dose was maximum in the kidneys (2.13E−01 mGy/MBq), followed by liver (3.03E−02 mGy/MBq), spleen (2.90E−02 mGy/MBq), adrenals (2.67E−02 mGy/MBq), and urinary bladder (1.89E−02 mGy/MBq).

Conclusion
Whole-body effective dose from 18F-PSMA-1007 is higher compared with 68Ga-PSMA-11-HBED-CC. 18F-PSMA-1007 shows lesser urinary bladder clearance compared with 68Ga-PSMA-11-HBED-CC, which can allow better interpretation of prostatic bed without significant radioactive urine interference. 18F-PSMA-1007 is a cyclotron-produced alternative to generator-produced 68Ga-PSMA-11-HBED-CC and can emerge as a good diagnostic surrogate for patients planned for 177Lu-PSMA-617 therapy.
“Hood Sign” in Nuclear Medicine: An Unusual Presentation of Mantle Cell Lymphoma as Detected on FDG PET/CT
Authors: Prakash Anjali , Purandare Nilendu , Shah Sneha , Agrawal Archi , Puranik Ameya , Rangarajan Venkatesh 
Published: August 2022

Abstract
Mantle cell lymphoma is a rare and aggressive non-Hodgkin lymphoma with a high propensity for extranodal involvement, typically seen in the liver, marrow, and gastrointestinal system. Being an FDG-avid disease and a sensitive modality for detecting both nodal and extranodal disease, FDG PET/CT is recommended in the workup of mantle cell lymphoma. We present a rare pattern of cutaneous involvement of the head-neck region in a patient with mantle cell lymphoma, which can be described on FDG PET/CT as a “hood sign.”
Comparison of 18F-DOPA and 18F-DTBZ for PET/CT Imaging of Idiopathic Parkinson Disease
Authors: Shi Xinchong , Yang Yang , Jiang LuLu , Chen Jinhua , Yi Chang , Luo Ganhua , Wu Lei , Chu Jianmin , Wang Jian , Chen Ling , Zhang Xiangsong 
Published: August 2022

Objective
The aim of this study was to compare 2 imaging tracers, 18F-DOPA and 18F-DTBZ, for PET/CT imaging in idiopathic Parkinson disease (PD).

Methods
We recruited 32 PD patients and 12 healthy controls in this study. All subjects underwent both 18F-DOPA and 18F-DTBZ PET/CT, and the results were interpreted by visual analysis and semiquantitative analysis (specific uptake ratios [SURs]). A 1-way analysis of variance was used to compare the clinical data and the SURs among the patients at different stages. Regression analysis was performed to analyze the correlation between the SURs and the clinical data.

Results
Among the PD patients, there were 7 patients in Hoehn and Yahr stage I, 14 patients in stage II, and 11 patients in stage III. Linear correlation was found in striatal SURs between the 2 tracers (P < 0.05). In patients of early stages, the striatal SUR decrease percent of 2 tracers had no statistical difference (paired t test, P > 0.05). By initial visual analysis, all the patients were interpreted as positive with 18F-DBTZ (6 unilaterally, 26 bilaterally), and 31 cases were regarded as positive with 18F-DOPA (8 unilaterally, 23 bilaterally). After setting the upper limit of SUR images with the putamen SURs of healthy controls (SURT), all patients were interpreted as positive with both tracers (18F-DTBZ: 5 unilaterally, 27 bilaterally; 18F-DOPA: 4 unilaterally, 28 bilaterally).

Conclusion

18F-DTBZ and 18F-DOPA could reflect the same level of dopaminergic neuron degeneration for PD in early stages, and they have the consistent visual analysis results.
Baseline 18F-FDG PET/CT May Portend the Prognosis of Patients With Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma After First-Line Treatment
Authors: Pan Qingqing , Cao Xinxin , Luo Yaping , Li Jian , Li Fang 
Published: August 2022

Purpose
The outcome of patients with Waldenström macroglobulinemia/lymphoplasmacytic lymphoma (WM/LPL) is variable. We aim to study if baseline 18F-FDG PET/CT has some prognostic significance in WM/LPL.

Methods
Thirty-three patients with newly diagnosed WM/LPL who underwent baseline 18F-FDG PET/CT and received active treatment thereafter were recruited in this retrospective study. Semiquantitative indices of baseline 18F-FDG PET/CT were measured as total lesion glycolysis (TLG), metabolic tumor volume (MTV), and SUVmax. The patients were followed up for at least 3 years or until reaching the endpoint, which were defined as progression-free survival (PFS) and the time to next treatment (TTNT).

Results
The overall response rate of the first-line treatment in the recruited patients was 84.8% (28/33). The 3-year PFS and overall survival rates were 56.3% and 89.3%, respectively. Patients with PFS <36 months and TTNT <36 months showed TLG and MTV significantly higher than those with PFS ≥36 months and TTNT ≥36 months (P < 0.05). SUVmax in patients with PFS <36 months was significantly higher than those with PFS ≥36 months (P = 0.033). Receiver operating characteristic analysis demonstrated that cutoff values of TLG >291.28 SUVbw * mL, MTV >108.78 mL, and SUVmax >3.16 were optimal for predicting PFS <36 months. Kaplan-Meier analysis showed that TLG >291.28 SUVbw * mL and MTV >108.78 mL were predictive for shorter PFS (P = 0.003) and TTNT (P = 0.002). In multivariate analysis, TLG >291.28 SUVbw * mL and MTV >108.78 mL were independent predictors for shorter PFS (hazard ratio, 3.06; 95% confidence interval, 1.09–8.57; P = 0.033) and TTNT (hazard ratio, 10.01; 95% confidence interval, 2.56–39.22; P = 0.001).

Conclusions
The metabolic indices of TLG and MTV in baseline 18F-FDG PET/CT were independent prognostic factors to predict PFS and TTNT in patients with WM/LPL.