bluuebunny/crossref_metadata_2025_split huggingface dataset:
Induced Degradation of Lineage-specific Oncoproteins Drives the Selective PARP1 Inhibitor Toxicity in Small Cell Lung Cancer
Authors: Kim Chiho , Wang Xu-Dong , Wang Shuai , Li Peng , Zi Zhenzhen , Ding Qing , Jang Seoyeon , Kim Jiwoong , Luo Yikai , Huffman Kenneth E. , Cai Ling , Liang Han , Minna John D. , Yu Yonghao 
Published: November 2022

AbstractA subset of small cell lung cancer (SCLC) shows clinically relevant response to PARP1 inhibitors (PARPi). However,BRCA1/2mutations are not commonly found in SCLC, and the underlying mechanism(s) of PARPi sensitivity in SCLC is poorly understood. We performed quantitative proteomic analyses and identified proteomic changes that signify PARPi responses in a large panel of molecularly annotated patient-derived SCLC lines. We found that the toxicity of PARPi in SCLC could be explained, at least in part, by the PARPi-induced degradation of key lineage-specific oncoproteins including ASCL1, NEUROD1, POU2F3, KDM4A, and KDM5B. Importantly, the degradation of these SCLC lineage-specific oncoproteins could also be induced by commonly used chemotherapeutic agents. Biochemical experiments showed that PARPi-induced activation of E3 ligases (e.g., HUWE1 and RNF8) mediated the ubiquitin-proteasome system (UPS)-dependent degradation of these oncoproteins. Interestingly, although PARPi resulted in a general DNA damage response in SCLC cells, this signal is sensed by different SCLC cell lines to generate a cell-specific response. The dissection of the cell-specific oncoprotein degradation response led to the identification of potentially predictive biomarkers for PARPi in SCLC. The combination of PARPi and agents targeting these pathways led to dramatically improved cytotoxicity in SCLC. PARPi-induced degradation of lineage-specific oncoproteins therefore represents a novel mechanism to explain the efficacy of PARPi in tumors withoutBRCA1/2mutations.HighlightsQuantitative mass spectrometric analysis identifies proteomic changes associated with PARPi treatment in a large panel of SCLC cell lines.PARPi leads to the degradation of lineage-specific oncoproteins (e.g., ASCL1 and KDM4A) via the DNA damage responsive E3 ubiquitin ligases (e.g., HUWE1 and RNF8).A combination of PARPi and agents targeting the lineage-specific oncoproteins offers a more complete and durable therapeutic response in SCLC, compared to PARPi alone.Expression of lineage-specific oncoproteins and the associated ubiquitination machinery are predictive biomarkers for PARPi-induced cytotoxicity in SCLC.
Contract Types, Institutional Distance and Operational Performance: Evidence from Global Trade Flows in the LNG Industry
Authors: Batsakis Georgios , Robotis Andreas , Koulamas Christos , Zeritis Fotios 
Published: November 2022

AbstractIn this study, we examine the relationship between contract types, institutional distance and operational performance in the context of cross‐border trade in the liquefied natural gas (LNG) industry. Drawing on the buyer–supplier long‐term relationships literature, we argue for a negative link between short‐term contractual agreements and operational performance. Further, drawing insights from institutional theory, we contend that a high level of formal and informal institutional distance between the origin (i.e. supplier) and destination (i.e. buyer) countries reduces operational performance. We also argue that formal and informal institutional distance mitigates the negative effect of short‐term contracts on operational performance. Finally, we draw on the role of ‘asymmetry in distance’ by examining the direct and moderating effect of both the relevance and direction of formal institutional distance. We test our assumptions using LNG global trade flows from 39 source countries to 44 destination countries over the 2008–2017 period (a total of 17,447 shipments). Our study extends our knowledge on the operational performance implications of buyer–supplier relationships and stresses the important role formal and informal institutional distance plays as a direct and moderating effect on this relationship.
Comparison of outcomes and costs of extracorporeal blood purification therapies in critically ill COVID‐19 patients
Authors: Dianaty Soroush , Khodadadi Sanaz , Alimoghaddam Rojina , Mirzaei Abasat 
Published: November 2022

AbstractIntroductionPlasmapheresis and hemoperfusion are used against cytokine release syndrome in COVID‐19. This study aims to compare their outcomes, costs, and side‐effects.MethodsSurvival, costs and side‐effects were compared in intensive care unit (ICU) patients receiving plasmapheresis (n = 49), hemoperfusion (n = 20), or none (n = 107), followed until death or discharge.ResultsPlasmapheresis survival time was higher than hemoperfusion or controls (HR = 0.764, p = 0.397 and HR = 0.483, p = 0.002, respectively), although the latter diminished after controlling for age and disease severity (p = 0.979). There was no significant difference in ICU costs for plasmapheresis and hemoperfusion (p = 0.738) while both costed more than controls (both p < 0.001). Hypocalcemia and thrombocytopenia incidence did not differ between two groups (p = 0.124 and p = 0.389, respectively) while being higher than controls in plasmapheresis (both p < 0.001) and hemoperfusion (p < 0.001 and p = 0.056, respectively).ConclusionPlasmapheresis and hemoperfusion do not differ significantly in patient survival, ICU costs and side‐effects with a higher incidence of hypocalcemia and thrombocytopenia compared witcontrols.
Reduced complexity models for regional aquatic habitat suitability assessment
Authors: Goodrum Gregory C. , Null Sarah E. 
Published: November 2022

AbstractGeneralizable methods that identify suitable aquatic habitat across large river basins and regions are needed to inform resource management. Habitat suitability models intersect environmental variables to predict species occurrence, but are often data intensive and thus are typically developed at small spatial scales. This study estimated mean monthly aquatic habitat suitability throughout Utah (USA) for Bonneville Cutthroat Trout (Oncorhynchus clarkii utah) and Bluehead Sucker (Catostomus discobolus) with publicly available, geospatial datasets. We evaluated 15 habitat suitability models using unique combinations of percent of mean annual discharge, velocity, gradient, and stream temperature. Environmental variables were validated with observed conditions and species presence observations to verify habitat suitability estimates. Stream temperature, gradient, and discharge best predicted Bonneville Cutthroat Trout presence, and gradient and discharge best predicted Bluehead Sucker presence. Simple aquatic habitat suitability models outperformed models that used only streamflow to estimate habitat for both species, and are useful for conservation planning and water resources decision‐making. This modeling approach could enable resource managers to prioritize stream restoration across vast regions within their management domain, and is potentially compatible with water management modeling to improve ecological objectives in management models.
Systematic review: microbial manipulation as therapy for primary sclerosing cholangitis
Authors: Bogatic Damjana , Bryant Robert V. , Lynch Kate D. , Costello Samuel P. 
Published: November 2022

SummaryBackgroundPrimary sclerosing cholangitis (PSC) is a progressive liver disease with poor prognosis and no effective therapies to prevent progression. An aetiopathological link between PSC and gastrointestinal microbial dysbiosis has been suggested.AimTo evaluate all potential medical therapies which may exert their effect in PSC by modulation of the gut‐liver axis.MethodsWe conducted a comprehensive scoping review of PubMed and Cochrane Library, including all articles evaluating an intervention aimed at manipulating the gastrointestinal microbiome in PSC.ResultsA wide range of therapies proposed altering the gastrointestinal microbiome for the treatment of PSC. In particular, these considered antibiotics including vancomycin, metronidazole, rifaximin, minocycline and azithromycin. However, few therapies have been investigated in randomised, placebo‐controlled trials. Vancomycin has been the most widely studied antibiotic, with improvement in alkaline phosphatase reported in two randomised controlled trials, but with no data on disease progression. Unlike antibiotics, strategies such as faecal microbiota transplantation and dietary therapy can improve microbial diversity. However, since these have only been tested in small numbers of patients, robust efficacy data are currently lacking.ConclusionsThe gut‐liver axis is increasingly considered a potential target for the treatment of PSC. However, no therapies have been demonstrated to improve transplant‐free survival. Innovative and well‐designed clinical trials of microbiome‐targeted therapies with long‐term follow‐up are required for this orphan disease.
Colour‐emotion association and colour preference for elder care robot appearance
Authors: Liao Ching‐Chih , Hsu Ya‐Han 
Published: November 2022

AbstractWith the population ageing in Taiwan, it is projected that elder care robots incorporating smart technologies will play an essential role in ambient assisted living. This research has two purposes: (1) to investigate whether older adults' colour‐emotion associations and colour preferences for robot appearance affect their perceptual judgements; and (2) to explore gender differences in their judgements. Phase I of this research uses a questionnaire to investigate 91 participants' preferences for robot style and their emotional trigger words for the role of robots. Phase II experiments were performed on another 60 older adults to identify whether their colour‐emotion associations and colour preferences affect their perceptual judgements. The research results show that, regardless of gender difference, participating older adults prefer a robot with non‐human–like features. The results also show that there is no significant difference between males and females in terms of the effect of colour‐emotion association on a robot's appearance. Older adults tend to associate warm colours with emotional semantics, such as friendly, comfortable, reassuring, gentle and lively. Preferred colours include red, white and yellow. Black and grey are almost never preferred by older adults. There are significant differences by gender in the preferences for the colours white and purple. Older females prefer purple more, while white is preferred by older males. For the other colours, there were no significant differences between males and females. Colour attributes do not have any effect on colour‐emotion association, whereas colour preference is highly positively correlated with b*.
Using storytelling in undergraduate dental education: Students' experiences of emotional competence training
Authors: Johnsen Jan‐Are K. , Borit Melania , Stangvaltaite‐Mouhat Lina 
Published: November 2022

AbstractAimThe aim of the study was to explore the use of storytelling as a teaching method for emotional competence interventions within undergraduate dental curriculum (dental and dental hygiene students).Materials and MethodsStudents participated in five sessions related to emotional competence: one theoretical and four practical. During the latter, divided in small groups, students told individually two stories: a story about a clinical situation in which they had an emotional experience and a story concerning a patient's experience of the same emotion. Each session focused on a single emotion: happiness, fear, anger and shame. A questionnaire was used to collect perceptions about enjoyment, how stories were chosen, what was learned and if the sessions were stimulating in any way. A focus group was organised to collect reflections about the learning environment, process of learning and specific skill set developed during these sessions.ResultsThe majority of the students enjoyed listening, telling and preparing the stories. They reported to experience social support and feeling a sense of community during the sessions. The students believed that stories helped them to reflect on their clinical work and to regulate their emotional experiences more efficiently in clinical situations. Regarding the learning environment, the dental students pointed out the distinctiveness and dissimilarities between the dental and dental hygiene students, but also expressed that they had a desire to learn more about the other student group.ConclusionStorytelling used as part of an emotional competence course appears to have benefits for students' reflection about their role as dental health professionals. This teaching method was well‐perceived by the students included in this study.
Etiologic and prognostic value of external carotid artery thrombus detection during endovascular therapy for anterior circulation proximal occlusions
Authors: Courret Thomas , Tourdias Thomas , Papaxanthos Jean , Labreuche Julien , Gariel Florent , Liegey Jean‐Sebastien , Olindo Stephane , Renou Pauline , Berge Jerome , Barreau Xavier , Sagnier Sharmila , Menegon Patrice , Lucas Ludovic , Briau Pierre , Poli Mathilde , Debruxelles Sabrina , Rouanet François , Dousset Vincent , Sibon Igor , Marnat Gaultier 
Published: November 2022

AbstractBackground and purposeAn early understanding of stroke mechanism may improve treatment and outcome in patients presenting with large vessel occlusion stroke (LVOS) treated with mechanical thrombectomy (MT). We aimed to investigate whether spontaneous external carotid artery (ECA) embolism detection during MT is associated with stroke etiology and clinical outcome.MethodsWe retrospectively reviewed our prospectively maintained institutional database including consecutive patients with anterior circulation LVOS treated with MT between January 2015 and August 2020.ResultsAn ECA embolus was detected in 68 of 1298 patients (5.2%). The kappa coefficient for interobserver agreement was 0.89 (95% confidence interval [CI] 0.82–0.95). ECA embolism was significantly associated with intracranial internal carotid artery (ICA) occlusion (p < 0.001), cardioembolic etiology (p < 0.001) and a lower clot burden score (p < 0.001). Day‐1 variation of National Institutes of Health Stroke Scale score (adjusted odds ratio [OR] −2.7, 95% CI −4.9 to 0.3; p = 0.021) and delta Alberta Stroke Program Early Computed Tomography Score (adjusted OR 0.9, 95% CI 0.2 to 1.5; p = 0.004) were worse among patients with ECA emboli. There was no significant difference in 90‐day functional outcome between groups (adjusted OR 0.8, 95% CI 0.42 to 1.52; p = 0.50).ConclusionIn patients with anterior circulation LVOS treated with MT, ECA embolism was significantly associated with cardioembolic etiology, high thrombus burden and proximal intracranial ICA occlusions. This underexplored angiographic pattern might provide a valuable etiologic clue to the underlying cause of anterior circulation LVOS and may also help determine the appropriate revascularization strategy.
Photoperiod influences the development and the expression of personality traits and social behaviour in wild cavies (Cavia aperea)
Authors: Guenther Anja , Trillmich Fritz 
Published: November 2022

AbstractSeasonality influences behaviour, physiology and life history of organisms, and photoperiod is a reliable and influential cue gearing individual adaptation to seasonal changes in the environment. Plastic phenotypic adjustments according to the prevailing season are a widespread, well‐studied phenomenon. Less well known are effects on developmental trajectories of animals born into different seasons. By manipulating the photoperiod during pregnancy and lactation independent of food availability and temperature, we studied if maternal behaviour in the precocial wild cavy (Cavia aperea) responds to this seasonal cue and if maternal behaviour and photoperiod shape offspring development and behaviour. We repeatedly observed mothers before and after birth. We investigated if pups differ in risk‐taking behaviours directly after birth (indicating direct prenatal effects) or only after gaining independence of the mother (indicating delayed prenatal or postnatal effects due to own cue sampling). Furthermore, we tested if different simulated seasons of birth affect social and aggressive behaviour of adult animals. While theoretical predictions according to risk‐taking are quite clear, they are contradictory for social behaviours that are much less well studied. We predicted that animals born into spring photoperiods would be aggressive because of a need to gather enough resources for early reproduction and successfully establishing a territory at least in males. Spring‐born males were more aggressive than autumn‐borns, while females did not differ with respect to season. Spring‐born females, however, lost more body mass when they had to integrate into an established group and autumn‐born females initiated more aggressive interactions. Our data demonstrate flexible and long‐term stable seasonal effects on behaviours that likely affect fitness outcomes under natural conditions.
A novel YOLOv4‐modified approach for efficient object detection in satellite imagery
Authors: Tiwari Rishabh , Dubey Ashwani Kumar , Rocha Alvaro 
Published: November 2022

AbstractInterpreting high‐resolution satellite imagery could be an expensive and time‐consuming task for human eyes. Computer Vision and Deep Learning techniques can help to solve this major problem by applying detection algorithms, which can ease the task of analysing such images for the benefit of humans. It can help in changing the way we comprehend and anticipate the economic activity around the world. Such techniques help us to observe the urban development in high security areas such as national and international borders. Constant progressions in improving and making satellites deployment, a cost‐effective process to strengthen the networks of satellite orbiting the earth is one of the reasons such tasks can be easily solved with the help of high‐resolution images. Current computer vision research works have achieved significant milestones in accuracy and speed but, there are still room for improvements. In this paper, we addressed some of these methods to bring them to a combined pipeline and proposed a set of improvements to further improve the speed and the accuracy of the detections. We proposed a unified framework, which combines several object detection algorithms and the state‐of‐art architecture of YoloV4 along with the TensorFlow object detection API. This framework can detect small and well as large objects with improved speed and accuracy by using two detectors for different scales. Evaluation ran on these high‐resolution images yield mAP of 85.6% F1‐score of 0.84.
Genetic polymorphisms of IL6 gene –174G > C and –597G > A are associated with the risk of COVID‐19 severity
Authors: Verma Shrikant , Verma Sushma , Khan Faizan Haider , Siddiqi Zeba , Raza Syed Tasleem , Abbas Mohammad , Mahdi Farzana 
Published: November 2022

AbstractCoronavirus disease‐2019 (COVID‐19) is pro‐inflammatory disorder characterized by acute respiratory distress syndrome. Interleukin‐6, a cytokine secreted by macrophages, which mediates an inflammatory response, is frequently increased and associated with the severity in COVID‐19 patients. The differential expression of IL6 cytokine in COVID‐19 patients may be associated with the presence of single nucleotide polymorphisms (SNPs) in regulatory region of cytokine genes. The aim of this study is to investigate the role of two promoter polymorphisms of the IL6 gene (–597G > A and –174G > C) with the severity of COVID‐19. The study included 242 patients, out of which 97 patients with severe symptoms and 145 patients with mild symptoms of COVID‐19. Genotyping of two selected SNPs, rs1800795 (–174G > C) and rs1800797 (–597G > A) of promoter region of IL6 gene, was performed by polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP). In our study, individuals with GC genotypes of IL6 (–174G > C) polymorphism showed significantly higher risk of severity [adjusted odds (OR) 3.86, p <.001] but we did not observe any association of COVID‐19 severity with rs1800797 (–597G > A) polymorphism. The COVID‐19 severity was significantly higher in individuals having ‘C’ allele of IL6 (–174G > C) polymorphism (p = .014). Linkage disequilibrium between rs1800795 (–174G > C) and rs1800797 (–597G > A) showed that individuals having AC* haplotype significantly association with COVID‐19 severity (p = .034). Our results suggest that ‘C’ allele of rs1800795 (–174G > C) polymorphism of IL6 may be the risk allele for severity of COVID‐19 in North Indian population.
The emerging role for metabolism in fueling neutrophilic inflammation
Authors: Morrison Tyler , Watts Emily R. , Sadiku Pranvera , Walmsley Sarah R. 
Published: November 2022

SummaryNeutrophils are a critical element of host defense and are rapidly recruited to inflammatory sites. Such sites are frequently limited in oxygen and/or nutrient availability, presenting a metabolic challenge for infiltrating cells. Long believed to be uniquely dependent on glycolysis, it is now clear that neutrophils possess far greater metabolic plasticity than previously thought, with the capacity to generate energy stores and utilize extracellular proteins to fuel central carbon metabolism and biosynthetic activity. Out‐with cellular energetics, metabolic programs have also been implicated in the production of neutrophils and their progenitors in the bone marrow compartment, activation of neutrophil antimicrobial responses, inflammatory and cell survival signaling cascades, and training of the innate immune response. Thus, understanding the mechanisms by which metabolic processes sustain changes in neutrophil effector functions and how these are subverted in disease states provides exciting new avenues for the treatment of dysfunctional neutrophilic inflammation which are lacking in clinical practice to date.