bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanisms of Neuromuscular Fatigability in People with Cancer-Related Fatigue
Authors: BROWNSTEIN CALLUM G. , TWOMEY ROSEMARY , TEMESI JOHN , MEDYSKY MARY E. , CULOS-REED S. NICOLE , MILLET GUILLAUME Y. 
Published: April 2022

ABSTRACT

Introduction
Cancer-related fatigue (CRF) is a debilitating symptom that affects around one-third of people for months or years after cancer treatment. In a recent study, we found that people with posttreatment CRF have greater neuromuscular fatigability. The aim of this secondary analysis was to examine the etiology of neuromuscular fatigability in people with posttreatment CRF.

Methods
Ninety-six people who had completed cancer treatment were dichotomized into two groups (fatigued and nonfatigued) based on a clinical cut point for fatigue. Alterations in neuromuscular function (maximal voluntary contraction peak force, voluntary activation, potentiated twitch force, and EMG) in the knee extensors were assessed across three common stages of an incremental cycling test. Power outputs during the fatigability test were expressed relative to gas exchange thresholds to assess relative exercise intensity.

Results
The fatigued group had a more pronounced reduction in maximal voluntary contraction peak force and potentiated twitch force throughout the common stages of the incremental cycling test (main effect of group: P < 0.001, η
p
2 = 0.18 and P = 0.029, η
p
2 = 0.06, respectively). EMG was higher during cycling in the fatigued group (main effect of group: P = 0.022, η
p
2 = 0.07). Although the relative intensity of cycling was higher in the fatigued group at the final common stage of cycling, this was not the case during the initial two stages, despite the greater impairments in neuromuscular function.

Conclusions
Our results suggest that the rapid impairments in neuromuscular fatigability in people with CRF were primarily due to disturbances at the level of the muscle rather than the central nervous system. This could affect the ability to tolerate daily physical activities.
Heat Training Efficiently Increases and Maintains Hemoglobin Mass and Temperate Endurance Performance in Elite Cyclists
Authors: RØNNESTAD BENT R. , URIANSTAD TOMAS , HAMARSLAND HÅVARD , HANSEN JOAR , NYGAARD HÅVARD , ELLEFSEN STIAN , HAMMARSTRÖM DANIEL , LUNDBY CARSTEN 
Published: April 2022

ABSTRACT

Purpose and Methods
To test whether heat training performed as 5 × 50-min sessions per week for 5 wk in a heat chamber (CHAMBER) or while wearing a heat suit (SUIT), in temperate conditions, increases hemoglobin mass (Hbmass) and endurance performance in elite cyclists, compared with a control group (CON-1). Furthermore, after the 5-wk intervention, we tested whether three sessions per week for 3 wk with heat suit (SUITmain) would maintain Hbmass elevated compared with athletes who returned to normal training (HEATstop) or who continued to be the control group (CON-2).

Results
During the initial 5 wk, SUIT and CHAMBER increased Hbmass (2.6% and 2.4%) to a greater extent than CON-1 (−0.7%; both P < 0.01). The power output at 4 mmol·L−1 blood lactate and 1-min power output (W
max) improved more in SUIT (3.6% and 7.3%, respectively) than CON-1 (−0.6%, P < 0.05; 0.2%, P < 0.01), whereas this was not the case for CHAMBER (1.4%, P = 0.24; 3.4%, P = 0.29). However, when SUIT and CHAMBER were pooled this revealed a greater improvement in a performance index (composed of power output at 4 mmol·L−1 blood lactate, W
max, and 15-min power output) than CON-1 (4.9% ± 3.2% vs 1.7% ± 1.1%, respectively; P < 0.05). During the 3-wk maintenance period, SUITmain induced a larger increase in Hbmass than HEATstop (3.3% vs 0.8%; P < 0.05), which was not different from the control (CON-2; 1.6%; P = 0.19), with no differences between HEATstop and CON-2 (P = 0.52).

Conclusions
Both SUIT and CHAMBER can increase Hbmass, and pooling SUIT and CHAMBER demonstrates that heat training can increase performance. Furthermore, compared with cessation of heat training, a sustained increase in Hbmass was observed during a subsequent 3-wk maintenance period, although the number of weekly heat training sessions was reduced to 3.
Loci Equidistant from Two Given Geometric Figures. Part 5: Loci Equidistant from a Sphere and a Plane
Authors: Vyshnyepolskiy Vladimir , Zavarihina E. , Egiazaryan K. 
Published: April 2022

In this paper have been investigated the loci equidistant from sphere and plane, and properties of obtained surfaces have been studied. Four options for possible mutual arrangement of plane and sphere have been considered: the plane passes through the center of the sphere; the plane intersects the sphere; the plane is tangent to the sphere; the plane passes outside the sphere.
In all options of the mutual arrangement of the sphere and the plane, the loci are two surfaces - two coaxial confocal paraboloids of revolution. The general properties of the obtained paraboloids of revolution have been studied: foci and vertices positions, axes of rotation, the distance from the sphere center to the vertices of the paraboloids, the distance between the vertices of the paraboloids, and the position of the directorial planes have been defined.
Have been derived equations for the surfaces of the loci equidistant from the sphere and the plane: various paraboloids of revolution.
The loci in each of the four options for the possible mutual arrangement of the plane and the sphere are as follows. 1. The original plane passes through the sphere center – two coaxial confocal multidirectional paraboloids of revolution symmetric relative to the original plane. 2. The initial plane intersects the sphere – two coaxial confocal multidirectional but not symmetrical paraboloids of revolution, since the circle of intersection of the plane and the sphere does not coincide with the diameter of the sphere great circle. 3. The plane is tangent to the sphere – a paraboloid of revolution and a straight line (more precisely, a second order zero-quadric – a cylindrical surface with zero radius) passing through the tangency point of the plane and the sphere and the sphere center. 4. The plane passes outside the sphere – the equidistant loci will be two coaxial confocal unidirectional paraboloids of revolution.
Online Mixed-Integer Optimization in Milliseconds
Authors: Bertsimas Dimitris , Stellato Bartolomeo 
Published: April 2022

We propose a method to approximate the solution of online mixed-integer optimization (MIO) problems at very high speed using machine learning. By exploiting the repetitive nature of online optimization, we can greatly speed up the solution time. Our approach encodes the optimal solution into a small amount of information denoted as strategy using the voice of optimization framework. In this way, the core part of the optimization routine becomes a multiclass classification problem that can be solved very quickly. In this work, we extend that framework to real-time and high-speed applications focusing on parametric mixed-integer quadratic optimization. We propose an extremely fast online optimization method consisting of a feedforward neural network evaluation and a linear system solution where the matrix has already been factorized. Therefore, this online approach does not require any solver or iterative algorithm. We show the speed of the proposed method both in terms of total computations required and measured execution time. We estimate the number of floating point operations required to completely recover the optimal solution as a function of the problem dimensions. Compared with state-of-the-art MIO routines, the online running time of our method is very predictable and can be lower than a single matrix factorization time. We benchmark our method against the state-of-the-art solver Gurobi obtaining up to two to three orders of magnitude speedups on examples from fuel cell energy management, sparse portfolio optimization, and motion planning with obstacle avoidance. Summary of Contribution: We propose a technique to approximate the solution of online optimization problems at high speed using machine learning. By exploiting the repetitive nature of online optimization, we learn the mapping between the key problem parameters and an encoding of the optimal solution to greatly speed up the solution time. This allows us to significantly improve the computation time and resources needed to solve online mixed-integer optimization problems. We obtain a simple method with a very low computing time variance, which is crucial in online settings.
Knowledge, practice and perceptions on exclusive breastfeeding among lactating mothers in rural primary health facilities in southwestern Nigeria
Authors: Amoo Tumilara Busayo , Anjola Adewunmi 
Published: April 2022

Background/Aims Exclusive breastfeeding is important for the growth and development of infants. Thus, it is important to examine the practice of exclusive breastfeeding and factors that may affect it. This study aimed to assess nursing mothers' knowledge on and practice of exclusive breastfeeding, the relationship between knowledge and practice and factors perceived to influence exclusive breastfeeding. Methods This cross-sectional study collected data using a self-designed questionnaire from mothers of children aged 0–6 months, at two primary health centres, Leslie and Igbogidi, in Ogun State, Nigeria. Participants were assessed on their knowledge and practice of exclusive breastfeeding, as well as their perceptions of factors that influence the practice of exclusive breastfeeding. Pearson's chi-squared test was used to assess the relationship between participants' knowledge and practice of exclusive breastfeeding. Results The majority (76.0%) of mothers had adequate knowledge on exclusive breastfeeding. However, only 58.5% practised exclusive breastfeeding for 6 months. There was a significant relationship between knowledge and practice of exclusive breastfeeding (P<0.000). Conclusions Participants' knowledge on exclusive breastfeeding did not coincide with its practice. Mothers should be supported through education and resources in order to improve rates of exclusive breastfeeding.
Lateral Incisor Root Resorption: A Consequence of Ectopic Maxillary Canine Teeth
Authors: Cooper Jessica , Storey Madeleine , Srinivasan Vidya 
Published: April 2022

Root resorption of permanent teeth is a recognized complication of ectopic maxillary permanent canines. This type of resorption is sometimes missed and can be diagnosed at the late presentation stage. Treatment of external resorption is complex and can require extraction of the affected tooth. This review provides an insight into the current evidence and guidance related to the interceptive treatment of displaced permanent maxillary canines to minimize the risk of resorption of adjacent teeth. Supported by two clinical cases, it looks into treatment options and long-term management of lateral incisors with external root resorption of varying severities. CPD/Clinical Relevance: Primary care practitioners are best placed to recognize displaced maxillary permanent canines in a timely manner, and so, root resorption of adjacent teeth may be prevented.
Incorporating global dynamics to improve the accuracy of disease models: Example of a COVID-19 SIR model
Authors: AlQadi Hadeel , Bani-Yaghoub Majid 
Published: April 2022

Mathematical models of infectious diseases exhibit robust dynamics, such as stable endemic, disease-free equilibriums or convergence of the solutions to periodic epidemic waves. The present work shows that the accuracy of such dynamics can be significantly improved by including global effects of host movements in disease models. To demonstrate improved accuracy, we extended a standard Susceptible-Infected-Recovered (SIR) model by incorporating the global dynamics of the COVID-19 pandemic. The extended SIR model assumes three possibilities for susceptible individuals traveling outside of their community:
• They can return to the community without any exposure to the infection.
• They can be exposed and develop symptoms after returning to the community.
• They can be tested positively during the trip and remain quarantined until fully recovered.
To examine the predictive accuracy of the extended SIR model, we studied the prevalence of the COVID-19 infection in six randomly selected cities and states in the United States: Kansas City, Saint Louis, San Francisco, Missouri, Illinois, and Arizona. The extended SIR model was parameterized using a two-step model-fitting algorithm. The extended SIR model significantly outperformed the standard SIR model and revealed oscillatory behaviors with an increasing trend of infected individuals. In conclusion, the analytics and predictive accuracy of disease models can be significantly improved by incorporating the global dynamics of the infection.
Detection of SARS-CoV-2 antibodies in febrile patients from an endemic region of dengue and chikungunya in Peru
Authors: Tarazona-Castro Yordi , Troyes-Rivera Lucinda , Martins-Luna Johanna , Cabellos-Altamirano Felipe , Aguilar-Luis Miguel Angel , Carrillo-Ng Hugo , del Valle Luis J. , Kym Sungmin , Miranda-Maravi Sebastian , Silva-Caso Wilmer , Levy-Blitchtein Saul , del Valle-Mendoza Juana 
Published: April 2022

Introduction
The rapid expansion of the novel SARS-CoV-2 virus has raised serious public health concerns due to the possibility of misdiagnosis in regions where arboviral diseases are endemic. We performed the first study in northern Peru to describe the detection of SARS-CoV-2 IgM antibodies in febrile patients with a suspected diagnosis of dengue and chikungunya fever.

Materials and methods
A consecutive cross-sectional study was performed in febrile patients attending primary healthcare centers from April 2020 through March 2021. Patients enrolled underwent serum sample collection for the molecular and serological detection of DENV and CHIKV. Also, serological detection of IgM antibodies against SARS-CoV-2 was performed.

Results
464 patients were included during the study period, of which (40.51%) were positive for one pathogen, meanwhile (6.90%) presented co-infections between 2 or more pathogens. The majority of patients with monoinfections were positive for SARS-CoV-2 IgM with (73.40%), followed by DENV 18.09% and CHIKV (8.51%). The most frequent co-infection was DENV + SARS-CoV-2 with (65.63%), followed by DENV + CHIKV and DENV + CHIKV + SARS-CoV-2, both with (12.50%). The presence of polyarthralgias in hands (43.75%, p<0.01) and feet (31.25%, p = 0.05) were more frequently reported in patients with CHIKV monoinfection. Also, conjunctivitis was more common in patients positive for SARS-CoV-2 IgM (11.45%, p<0.01). The rest of the symptoms were similar among all the study groups.

Conclusion
SARS-CoV-2 IgM antibodies were frequently detected in acute sera from febrile patients with a clinical suspicion of arboviral disease. The presence of polyarthralgias in hands and feet may be suggestive of CHIKV infection. These results reaffirm the need to consider SARS-CoV-2 infection as a main differential diagnosis of acute febrile illness in arboviruses endemic areas, as well as to consider co-infections between these pathogens.
Does a humoral correlate of protection exist for SARS-CoV-2? A systematic review
Authors: Perry Julie , Osman Selma , Wright James , Richard-Greenblatt Melissa , Buchan Sarah A. , Sadarangani Manish , Bolotin Shelly 
Published: April 2022

Background
A correlate of protection (CoP) is an immunological marker associated with protection against infection. Despite an urgent need, a CoP for SARS-CoV-2 is currently undefined.

Objectives
Our objective was to review the evidence for a humoral correlate of protection for SARS-CoV-2, including variants of concern.

Methods
We searched OVID MEDLINE, EMBASE, Global Health, Biosis Previews and Scopus to January 4, 2022 and pre-prints (using NIH iSearch COVID-19 portfolio) to December 31, 2021, for studies describing SARS-CoV-2 re-infection or breakthrough infection with associated antibody measures. Two reviewers independently extracted study data and performed quality assessment.

Results
Twenty-five studies were included in our systematic review. Two studies examined the correlation of antibody levels to VE, and reported values from 48.5% to 94.2%. Similarly, several studies found an inverse relationship between antibody levels and infection incidence, risk, or viral load, suggesting that both humoral immunity and other immune components contribute to protection. However, individual level data suggest infection can still occur in the presence of high levels of antibodies. Two studies estimated a quantitative CoP: for Ancestral SARS-CoV-2, these included 154 (95% confidence interval (CI) 42, 559) anti-S binding antibody units/mL (BAU/mL), and 28.6% (95% CI 19.2, 29.2%) of the mean convalescent antibody level following infection. One study reported a CoP for the Alpha (B.1.1.7) variant of concern of 171 (95% CI 57, 519) BAU/mL. No studies have yet reported an Omicron-specific CoP.

Conclusions
Our review suggests that a SARS-CoV-2 CoP is likely relative, where higher antibody levels decrease the risk of infection, but do not eliminate it completely. More work is urgently needed in this area to establish a SARS-CoV-2 CoP and guide policy as the pandemic continues.
FATORES DE HETEROGENEIDADE DO POTENCIAL ANTIOXIDANTE DA PRÓPOLIS DA ABELHA APIS MELLIFERA: UMA REVISÃO
Authors: Cruz Fernanda Baldomir da , Martins Diegue Henrique Nascimento , Ferreira Juliana de Freitas , Magalhães Pérola de Oliveira , Silveira Dâmaris , Fonseca-Bazzo Yris Maria 
Published: April 2022

As abelhas produzem a própolis a partir de materiais balsâmicos coletados das plantas. Trata-se de um produto natural com diversas funções dentro da colmeia. Atualmente, a ciência já comprovou várias ações biológicas desse material, tal como antioxidante. Porém, ainda há desafios no que concerne a padronização de técnicas de coleta, preparo da amostra, análises, controle de qualidade, dentre outros, dificultando o uso da própolis pela indústria. Essa revisão investigou os possíveis fatores de heterogeneidade do potencial antioxidante da própolis, considerando todo o processo de obtenção, desde origem das colmeias até formas de extração da própolis de abelha Apis mellifera. A busca desta revisão foi realizada nas seguintes bases de dados e ferramentas de busca: SciELO, Google Acadêmico, PubMed, MEDLINE, Catálogo de Dissertações e Teses da CAPES, BVS, CRD, Embase, Science Direct, Scopus e Cochrane Library. Foram incluídas publicações em português, inglês e espanhol (2011 a 2021). Foram obtidos 173 trabalhos que comprovaram importante atividade antioxidante do extrato de própolis de A. melífera. Porém, os resultados numéricos de potencial antioxidante diferiram muito entre si. Os principais fatores de heterogeneidade encontrados nas metodologias foram: local e época de coleta (sazonalidade), raça da abelha, tipo de própolis ou sua fonte botânica, e preparo do extrato (solvente, tempo e metodologia de extração).
POTENCIAL ANTINEOPLÁSICO DO ÁCIDO CARNÓSICO ENCONTRADO NA ESPÉCIE Rosmarinus Officinalis L., LAMIACEAE (ALECRIM): UMA REVISÃO DE LITERATURA
Authors: Da Silva Iran Alves , Sultanun Rozana Firmino de Souza , Da Silva Felipe Stallone , Vila Luana Raide Sanguineto , Barbosa Talismania da Silva Lira , De Melo Clêidiane Clemente , Laurentino Carolayne da Silva , Da Silva Jamicelly Rayanna Gomes 
Published: April 2022

O ácido carnósico é um dos principais diterpenos fenólicos antioxidantes presentes no alecrim (Rosmarinus officinalis L.), com destaque no potencial antineoplásico. Assim, este trabalho tem como objetivo investigar na literatura o potencial antineoplásico do ácido carnósico presente em Rosmarinus officinalis L. Trata-se de um estudo retrospectivo narrativo, em que foi realizada uma revisão de literatura nas bases de dados: SciELO, ScienceDirect, PubMed e Google Acadêmico, utilizando as palavraschave: Rosmarinus officinalis, ácido carnósico, antineoplásico e fitoterapia no período de 2015 a 2020. Rosmarinus officinalis L. apresenta diversas ações farmacológicas, dentre elas, antioxidante e antitumoral, conferidos pelos compostos ácido carnósico, carnosol e rosmanol. O efeito antioxidante relacionado a esses compostos fenólicos evita o estresse oxidativo celular e a proliferação celular descontrolada que poderia culminar em um câncer. O ácido carnósico, nesse sentido, é conhecido por exibir atividade anticâncer eficaz contra várias linhas de células tumorais: leucemia e câncer de mama, próstata, pulmão e fígado. É uma molécula capaz de inibir a proliferação e a capacidade de migração em células colorretais humanas por meio da inibição da ativação da uroquinase plasminogênio, enzima esta, responsável pela dissolução dos coágulos de fibrina, incluindo migração celular e inflamação. Nessa revisão foram identificadas as ações quimiopreventivas e antitumorais do ácido carnósico contra melanoma, leucemia, câncer de cólon, pulmão, próstata e fígado, células neoplásicas de neuroblastoma e de glioma.
New triple-mode high-amplitude Delta Scuti variables
Authors: Khruslov Anton V. 
Published: April 2022

Abstract
I present a detection of four new triple-mode high-amplitude Delta Scuti variables, pulsating in the fundamental, first, and second overtone modes. This is a new addition to the ten known cases in the Galaxy. I used the data of ASAS-SN and analyzed them using the WinEfk code by V. P. Goranskij. Light elements and parameters of the light curves were obtained.
Die Bibliotheken, die Welt der Bücher und die heutigen Trends: Haben traditionelle bibliothekarische Angebote überhaupt noch eine Zukunft?
Authors: Bisig Urs 
Published: April 2022

Zusammenfassung
Mit der fortschreitenden Digitalisierung wächst der Informationssektor immer schneller, die Orientierung darin wird immer schwieriger und anspruchsvoller, und der Komfort für die druckaffinen Leser nimmt ständig ab. Im Beitrag wird gezeigt, wie das Bibliothekswesen mithelfen kann, diese Entwicklung besser zu bewältigen. Der Autor ist der Meinung, das Ziel der Bibliotheken sollte nicht nur sein, möglichst bald Teil der E-Welt zu werden, sondern vor allem auch, diese intelligent zu ergänzen.
circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis
Authors: Wang Chunlin , Gong Junxia , Li Dai , Xing Xianghui 
Published: April 2022

Abstract
CircularRNAs (circRNAs) are collectively involved in periodontitis. The aim of this study was to explore the roles of circ_0062491 in osteogenic differentiation of PDLSCs and provide a novel method for periodontitis treatment. mRNA and protein expression levels were measured by qRT-PCR and western blotting. Alkaline phosphatase (ALP) and alizarin red S (ARS) staining were used to detect the activity of osteogenesis. Furthermore, the interactions between miR-142-5p and circ_0062491/IGF1 were verified by a luciferase reporter assay. circ_0062491 was suppressed in PDL tissues of periodontitis patients and overexpressed in osteogenesis-induced PDLSCs. Upregulated circ_0062491 promoted osteogenic differentiation of PDLSCs. miR-142-5p was verified to be a target of circ_0062491, and the overexpression of miR-142-5p suppressed the osteogenic differentiation of PDLSCs induced by circ_0062491 Additionally, miR-142-5p targeted IGF1, and silenced IGF1 abrogated the effects of suppressed miR-142-5p on osteogenic differentiation of PDLSCs. In conclusion, circ_0062491 acted as a competing endogenous RNA to regulate osteogenic differentiation of PDLSCs via the miR-142-5p/IGF1 axis.
Crystal structure of 5-nitroquinazolin-4(3H)-one, C8H5N3O3
Authors: Shi Lei , Wang Yu-Jiang , An Jun-Chao , Li Bin , Hu Ji 
Published: April 2022

Abstract
C8H5N3O3, monoclinic, P21/c (no. 14), a = 9.1778(16) Å, b = 7.0270(10) Å, c = 12.518(2) Å, β = 92.930(6)°, V = 806.3(2) Å3, Z = 4, R
gt(F
2) = 0.0469, wR

ref
(F
2) = 0.1353, T = 298 K.