bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomic discovery of chemical probes that perturb protein complexes in human cells
Authors: Lazear Michael R. , Remsberg Jarrett R. , Jaeger Martin G. , Rothamel Katherine , Her Hsuan-lin , DeMeester Kristen E. , Njomen Evert , Hogg Simon J. , Rahman Jahan , Whitby Landon R. , Won Sang Joon , Schafroth Michael A. , Ogasawara Daisuke , Yokoyama Minoru , Lindsey Garrett L. , Li Haoxin , Germain Jason , Barbas Sabrina , Vaughan Joan , Hanigan Thomas W. , Vartabedian Vincent F. , Reinhardt Christopher J. , Dix Melissa M. , Koo Seong Joo , Heo Inha , Teijaro John R. , Simon Gabriel M. , Ghosh Brahma , Abdel-Wahab Omar , Ahn Kay , Saghatelian Alan , Melillo Bruno , Schreiber Stuart L. , Yeo Gene W. , Cravatt Benjamin F. 
Published: December 2022

SummaryMost human proteins lack chemical probes, and several large-scale and generalizable small-molecule binding assays have been introduced to address this problem. How compounds discovered in such “binding-first” assays affect protein function, nonetheless, often remains unclear. Here, we describe a “function-first” proteomic strategy that uses size exclusion chromatography (SEC) to assess the global impact of electrophilic compounds on protein complexes in human cells. Integrating the SEC data with cysteine-directed activity-based protein profiling identifies changes in protein-protein interactions that are caused by site-specific liganding events, including the stereoselective engagement of cysteines in PSME1 and SF3B1 that disrupt the PA28 proteasome regulatory complex and stabilize a dynamic state of the spliceosome, respectively. Our findings thus show how multidimensional proteomic analysis of focused libraries of electrophilic compounds can expedite the discovery of chemical probes with site-specific functional effects on protein complexes in human cells.
Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere
Authors: Dendooven Tom , Zhang Ziguo , Yang Jing , McLaughlin Stephen H. , Schwab Johannes , Scheres Sjors H.W. , Yatskevich Stanislau , Barford David 
Published: December 2022

SummaryThe point centromere of budding yeast specifies assembly of the large multi-subunit kinetochore complex. By direct attachment to the mitotic spindle, kinetochores couple the forces of microtubule dynamics to power chromatid segregation at mitosis. Kinetochores share a conserved architecture comprising the centromere-associated inner kinetochore CCAN (constitutive centromere-associated network) complex and the microtubule-binding outer kinetochore KMN network. The budding yeast inner kinetochore additionally includes the centromere-binding CBF1 and CBF3 complexes. Here, we reconstituted the complete yeast inner kinetochore complex assembled onto the centromere-specific CENP-A nucleosome (CENP-ANuc) and determined its structure using cryo-EM. This revealed a central CENP-ANuc, wrapped by only one turn of DNA, and harboring extensively unwrapped DNA ends. These free DNA duplexes function as binding sites for two CCAN protomers, one of which entraps DNA topologically and is positioned precisely on the centromere by the sequence-specific DNA-binding complex CBF1. The CCAN protomers are connected through CBF3 to form an arch-like configuration, binding 150 bp of DNA. We also define a structural model for a CENP-ANuc-pathway to the outer kinetochore involving only CENP-QU. This study presents a framework for understanding the basis of complete inner kinetochore assembly onto a point centromere, and how it organizes the outer kinetochore for robust chromosome attachment to the mitotic spindle.
Earnings management contagion: evidence from institutional equivalence
Authors: Bansal Manish 
Published: December 2022

PurposeThe study aims to investigate how the presence and absence of institutional equivalents (interaction of industry peers and local peers) affect the earnings management practices of firms.Design/methodology/approachThe study uses discretionary accruals to operationalize earnings management. A sample of 18,744 Bombay Stock Exchange (BSE) listed firm years spanning over 12 financial years (March 2010–March 2021) has been considered and analyzed through panel data regression models.FindingsThe author’s results show that the earnings management practices of a firm's institutional equivalents and the firm's own earnings management are positively associated, implying that firms closely follow their institutional equivalents. This association is found to be more pronounced among focal firms when the difference between the earnings management levels of industry peers and local peers is greater. Further, the author find that large firms aggressively imitate their industry peers and local peers, whereas profitability does not influence their imitation behavior.Practical implicationsThe author’s findings have implications for understanding peer imitation processes, particularly when firms face increasingly multifaceted institutional environments. It suggests auditors and analysts take into account the earnings management practices of local and industry peers while analyzing the client's financial statements and making forecasts, respectively.Originality/valueThe study is among the pioneering attempts to explore the domain of earnings management from the lens of institutional equivalence and provides compelling evidence that the interaction of industry peers and local peers impacts the earnings management practices of firms.
Developing an alternative approach to the measurement of B2B relationship health
Authors: Bignoux Stephane , Gray David , Booth Anna Tudehope 
Published: December 2022

PurposePsychotherapy is often used to treat dysfunctional inter-personal relationships, but it is rarely used to treat dysfunctional B2B relationships. Yet many of the variables found in inter-personal relationships are also found in B2B relationships and both types of relationships have similar fail rates. The authors take a multi-disciplinary approach by adapting an instrument from marriage therapy into a new measure called the Business Relationship Health Index (BRHI). In the process we re-evaluate the drivers of B2B relationships.Design/methodology/approachThe authors apply the Global Assessment of Relational Functioning (GARF) psychiatric system to B2B relationships. The GARF instrument incorporates three components: interaction/problem solving, organization/structure and emotional climate. Using US panel data of 500 B2B relationships based in the USA, the authors use partial least squares analysis and develop a structural equation model to test the validity and reliability of the BRHI with some well-known relationship measures including, satisfaction, trust, commitment and performance.FindingsThe findings support a strong link between the BRHI (emotion, interaction and organization) and relationship performance. The proposed measure shows a strong link between BRHI and relationship performance (R2 = 0.54).Originality/valueThe GARF instrument has never been applied to a B2B context. BRHI is a holistic instrument used for assessing the specific relational characteristics of B2B relationships. The BRHI can benefit relationship stakeholders when used as a diagnostic tool to prioritize B2B investment strategies. Managers can use BRHI to determine the extent to which the relationship is healthy or needs repair, re-evaluation, re-commitment, or repositioning.
What is an equitable target percentage for women on corporate boards?
Authors: Lefley Frank , Janecek Vaclav 
Published: December 2022

PurposeThe corporate communications literature recently raised the question, “Board gender diversity and women in leadership positions – are quotas the solution?” This paper extends the debate by asking, “What is an equitable target percentage for women on corporate boards?”Design/methodology/approachThe paper explores and gives a conceptualised viewpoint on the issues expressed in the literature concerning the meaning of board gender equality, focussing on what is regarded as an equitable number of women on corporate boards.FindingsThe arguments and questions raised in this paper highlight the difficulty in answering the research question. The question will only be answered when it no longer needs to be raised. In other words, when gender equality is no longer seen as an issue and men and women are treated equally, when qualifications, experience and ability are the key issues on board selection, not gender. Highlighting gender inequality issues by setting target figures may in itself deter some women from seeking board-level promotion. The target should not just be to place women in what is currently a masculinised board culture but to change this culture to reflect non-masculinity.Practical implicationsThis paper can guide practitioners in their policy-making decisions on corporate board gender diversity and refocus the minds of academics on such an important issue. It should also help change the hegemonic understanding of leadership and thus influence recruitment policy.Originality/valueThis is believed to be the first paper to give a conceptualised viewpoint on the issue of targets concerning the number of women on corporate boards and brings into perspective the wide variation highlighted in the literature. It adds to the current debate on board gender diversity and the lack of women on corporate boards by highlighting the questions regarding gender targets. A research opportunity lies in exploring this paper's conceptual issues and questions by soliciting the views of male and female management students and corporate directors.
Redesigning workspace at Adobe: an Indian perspective
Authors: Kaur Taran , Bansal Sanjeev , Solomon Priya 
Published: December 2022

Purpose
The purpose of this study is to describe the success story of a software company, Adobe, in redesigning the workplace environment from cubicles to a connected collaborative workplace, which helped the organization optimize workplace usage. The goals were to design an innovative work environment to optimize the usage of the office portfolio, improve workplace service quality and infrastructure facilities of the portfolio, increase employee productivity, reduce technology costs, engage employees in a better way to enhance employee satisfaction, align workplace design with the brand, mobilize technology and enable a globalized workforce to facilitate higher productivity.

Design/methodology/approach
An exploratory research design method was adopted using the purposive sampling technique to collect data through semi-structured interviews with a team of nine property professionals from the operations team responsible for workspace redesign at Adobe in India.

Findings
The main observations of the corporate real estate (CRE) manager were on what value parameters drive workplace redesign and how different software companies were creating strategies to manage workplace design or redesign change for optimal use of the organization portfolio. To discuss the CRE strategies of global software leaders, IBM and SAP were pointed out in this case.

Research limitations/implications
The number of interviews were limited. The related parameters for workplace transformation are not necessarily complete. However, the parameters are regarded to include the most important aspects of workplace redesign.

Practical implications
This study provides useful insights into how benchmarking in the workplace transformation function of the CRE industry can be applied to address portfolio-related challenges, divergent employee needs and improve workspace usability following energy-efficient policies. Practitioners can use this study as a guide to develop more effective workspace designs.

Social implications
This study may guide other firms on successful workspace design initiatives that may overcome many obstacles in the workplace transformation process to have their intended impact on workplace efficiency and employee satisfaction. The case can be used as an inspiration for developing specific user-focused innovative workspace design in practice.

Originality/value
Adopting the theoretical background of the person–environment fit theory, this study adds to the understanding of the operational model of a digitally connected workspace designed as per real estate needs and strategies to manage the CRE portfolio of the company.
Aerospace financing towards Mars commercialisation
Authors: Harris Wesley L. , Wonglimpiyarat Jarunee 
Published: December 2022

Purpose
This paper aims to explore the financing mechanisms towards Mars commercialisation and SpaceX’s Mars mission programme to achieve the interplanetary settlement. This study also suggests the path to avoid the failure of space commercialisation.

Design/methodology/approach
This research uses a case study methodology (Eisenhardt, 1989; Yin, 2013). The analysis is based on the construct of technology S-curves and attempts to answer the research question: What are the financing mechanisms to achieve successful aerospace financing for Mars mission? This research used semi-structured questionnaire and conducted 51 in-depth interviews. The interview data were supported by an examination of secondary data to provide a cross check on the validity of research (Yin, 2013). The research findings provide lessons and insights into the challenges of aerospace financing to Mars.

Findings
This study has shown that financing via cryptocurrency and initial coin offering as well as crowdfunding (particularly donation- and equity-based crowdfunding) provide promising financial solutions to achieve Mars commercialisation. The implementation of Mars programme demonstrates the fifth generation of innovation development model – systems integration and extensive networking model.

Originality/value
Given a dearth of study focusing on the links between S-curves and technology financing of aerospace commercialisation, this research study attempts to fill a gap in this neglected area with a focus on exploring the financing mechanisms towards Mars commercialisation.
Mobile payment service adoption: understanding customers for an application of emerging financial technology
Authors: P.H. Haritha 
Published: December 2022

PurposeAs mobile payment systems have been in constant demand and are increasing in recent years, the various stakeholders involved in the process need to be identified. The study mainly includes ease of use, perceived usefulness, facilitating conditions, social influences, adoption readiness and intention to use financial technology (FinTech) in India. This paper aims to discuss FinTech and its dynamic changes in the banking sector. This study tests the mediation influence of perceived trust on adoption readiness and intention to use FinTech in India. The proposed impact of mediation of perceived trust was significant but small on adoption readiness and intention to use FinTech.Design/methodology/approachA questionnaire survey was administered to mobile payment users, and 349 responses were collected. Structural equations are analyzed to determine the proposed variables’ direct effects on adopting them. Additionally, to examine indirect effects, the mediation test is used.FindingsThe analysis results support the proposed model and thus help explain the impact of adoption readiness, trust and intention to use digital payment. The study’s significant findings will enable mobile payment institutions to understand the variables related to the growing use of technology in customers’ contexts. The study reveals the significance of ease of use, perceived usefulness and facilitating the service condition, which means that vendors prefer to use compatible devices that are easy to use with other devices. The analysis also explores the critical influence of perceived usefulness on customer behavior, enabling software designers to encourage accessible processes and device advantages for customers.Practical implicationsMobile payment systems offered by financial institutions until currently become a variety of mobile payment services due to rapidly evolving information technology. This work is a groundbreaking attempt to apply technology acceptance in recent years to the emerging framework of mobile banking systems. This study examines the adoption of mobile payment technologies by proposing an extended technology acceptance model (TAM) to capture the issues associated with adoption in India through banking users. Now customers are aware that cyberattacks on banking networks and data breaches quickly through media and social networks. Also, they know that the industry has done little to avoid or mitigate these attacks.Originality/valueThis study examines the adoption of mobile payment technologies by proposing an extended TAM to capture the issues associated with adoption in India through banking users.
Roadmap for product development based on design for six sigma method
Authors: Francisco Marta Gomes , Canciglieri Junior Osiris , Santanna Angelo Marcio Oliveira 
Published: December 2022

Purpose
The Design For Six Sigma (DFSS) methodology is one of the most important to achieving excellence in an organization’s product development process. This paper aims to propose a roadmap for product development based on the DFSS for the consumer durables manufacturing industries. The proposed roadmap presents a systematic approach to the phases of the product development process, integrating the statistical techniques and quality tools that should be used in each phase.

Design/methodology/approach
This study presents a detailed roadmap for product development, which was built by identifying gaps in the DFSS methods, based on previous studies on the subject. In this step, the opportunities are provided in all phases from creation to discontinuation of the product in the market. In addition, the roadmap presented was validated by team of stakeholders in the product development process of different industrial companies.

Findings
The proposed roadmap for the product development process based on six sigma design suggests a visual tool with sequential steps and techniques that allow you to follow the evolution of the development process from idea conception until the product is discontinued in the market. Identifying the priorities of organizations, especially the consumer, regarding the quality and reliability of the product.

Practical implications
The roadmap seeks to facilitate an understanding of the important stages of the product development process and to provide an approach to improving and optimizing the product before the manufacturing process step through the principles of DFSS methodology. This research provides a guide step by step to apply statistical techniques and quality tools in the product development process to achieve high quality and six sigma level in the manufacturing process.

Originality/value
The proposed roadmap of this research combines design for sigma and product development concepts, covering a wide spectrum of relevant activities that include the product development process, the application of statistical techniques and the design of high-quality durable consumer goods to match manufacturing technologies.
Prisoners’ experiences and coping strategies during the COVID-19 pandemic response – an ethnographic study conducted mid-pandemic
Authors: Munkholm Mathilde Carøe 
Published: December 2022

Purpose
This paper aims to report findings about how prisoners experience and cope with COVID-19 restrictions, which can contribute to an understanding of how pandemic responses, and specifically the COVID-19 response, affect prisoners.

Design/methodology/approach
Data was collected through ethnographic fieldwork involving days of observations (N = 24) and the conduction of semi-structured interviews with prisoners (N = 30) in closed prisons and detentions in Denmark between May and December 2021. The transcribed interviews and field notes were processed and coded by using the software programme NVivo.

Findings
The data analysis reveals that the pains of imprisonment have been exacerbated to people incarcerated during the COVID-19 pandemic. To relieve pains of imprisonment, prisoners turn to censoriousness as an informal coping strategy, where they complain about inconsistency and injustice in the prison’s COVID-19 prevention strategy to reveal the prison system itself as a rule-breaking institution. The prisoners criticise the prison management for using COVID-19 as an excuse, treating prisoners unjustly or not upholding the COVID-19 rules and human rights. Furthermore, principles of justice and equality are also alleged by some prisoners who contemplate the difficulty in treating all prisoners the same.

Research limitations/implications
More research will be needed to create a full picture of how prisoners cope with pandemic responses. Further research could include interviews with people working inside prisons.

Originality/value
In a Scandinavian context, to the best of the author’s knowledge, this study is the first of its kind to apply an ethnographic approach in exploring prison life during the COVID-19 pandemic.
Interventions for sustainable livelihoods: a review of evidence and knowledge gaps
Authors: Kumar Shubham , Sengupta Keya , Gogoi Bidyut Jyoti 
Published: December 2022

PurposeThe concept of sustainable livelihoods – commonly understood as managing of means of living without undermining natural resources – has gained momentum in international development discourse. This review focuses on broadening of conceptualisation of policy intervention process for sustainable livelihoods approach and synthesis of evidence to track development in their knowledge structure.Design/methodology/approachEvidence available in the literature systematically reviewed with the established methods and themes of interest are curated, to assess the characteristics, mechanisms and caveats arising in policy and practice.FindingsThe authors found seventy-five independent studies that fit into the pre-specified research protocol and objectives. The authors classify these studies into six major themes: Economic wellbeing; Opportunities and capabilities; Climate and natural resources; Policy design; Formal-informal institutional environment; and Labour, entrepreneurship and exports. Various research gaps and directions for future research are also discussed.Research limitations/implicationsThe study provides a typology of reviewed literature examining the profile dynamics. Thematic analysis resulted into identifying complementarities and trade-offs and results demonstrate multiple heterogeneity in structures, processes and outcomes.Originality/valueThe definitive areas of interventions are discussed to broaden the utility of the concept in a structured way. This review paper brings a comprehensive view of livelihood intervention system and contribute in enriching the social policy perspective.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-06-2022-0402