bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of shock duration on trauma-induced coagulopathy in a murine model
Authors: Sloos Pieter H. , Maas M. Adrie W. , Hollmann Markus W. , Juffermans Nicole P. , Kleinveld Derek J. B. 
Published: January 2022

Abstract
Background
Trauma-induced coagulopathy (TIC) is a life-threatening condition associated with high morbidity and mortality. TIC can present with different coagulation defects. In this study, the aim was to determine the effect of shock duration on TIC characteristics. We hypothesized that longer duration of shock leads to a more hypocoagulable rotational thromboelastometry (ROTEM) profile compared to a shorter duration of shock.

Methods
Male B57BL/6J(c) mice (n = 5–10 per group) were sedated and mechanically ventilated. Trauma was induced by bilateral lower limb fractures and crush injuries to the liver and small intestine. Shock was induced by blood withdrawals until a mean arterial pressure of 25–30 mmHg was achieved. Groups reflected trauma and shock for 30 min (TS30) and trauma and shock for 90 min (TS90). Control groups included ventilation only (V90) and trauma only (T90).

Results
Mice in the TS90 group had significantly increased base deficit compared to the V90 group. Mortality was 10% in the TS30 group and 30% in the TS90 group. ROTEM profile was more hypocoagulable, as shown by significantly lower maximum clot firmness (MCF) in the TS30 group (43.5 [37.5–46.8] mm) compared to the TS90 group (52.0 [47.0–53.0] mm, p = 0.04). ROTEM clotting time and parameters of clot build-up did not significantly differ between groups.

Conclusions
TIC characteristics change with shock duration. Contrary to the hypothesis, a shorter duration of shock was associated with decreased maximum clotting amplitudes compared to a longer duration of shock. The effect of shock duration on TIC should be further assessed in trauma patients.
An electrodynamics model for Data Interpretation and Numerical Analysis of ionospheric Missions and Observations (DINAMO)
Authors: Shidler Samuel A. , Rodrigues Fabiano S. 
Published: January 2022

AbstractWe introduce a new numerical model developed to assist with Data Interpretation and Numerical Analysis of ionospheric Missions and Observations (DINAMO). DINAMO derives the ionospheric electrostatic potential at low- and mid-latitudes from a two-dimensional dynamo equation and user-specified inputs for the state of the ionosphere and thermosphere (I–T) system. The potential is used to specify the electric fields and associated F-region E × B plasma drifts. Most of the model was written in Python to facilitate the setup of numerical experiments and to engage students in numerical modeling applied to space sciences. Here, we illustrate applications and results of DINAMO in two different analyses. First, DINAMO is used to assess the ability of widely used I–T climatological models (IRI-2016, NRLMSISE-00, and HWM14), when used as drivers, to produce a realistic representation of the low-latitude electrodynamics. In order to evaluate the results, model E × B drifts are compared with observed climatology of the drifts derived from long-term observations made by the Jicamarca incoherent scatter radar. We found that the climatological I–T models are able to drive many of the features of the plasma drifts including the diurnal, seasonal, altitudinal and solar cycle variability. We also identified discrepancies between modeled and observed drifts under certain conditions. This is, in particular, the case of vertical equatorial plasma drifts during low solar flux conditions, which were attributed to a poor specification of the E-region neutral wind dynamo. DINAMO is then used to quantify the impact of meridional currents on the morphology of F-region zonal plasma drifts. Analytic representations of the equatorial drifts are commonly used to interpret observations. These representations, however, commonly ignore contributions from meridional currents. Using DINAMO we show that that these currents can modify zonal plasma drifts by up to ~ 16 m/s in the bottom-side post-sunset F-region, and up to ~ 10 m/s between 0700 and 1000 LT for altitudes above 500 km. Finally, DINAMO results show the relationship between the pre-reversal enhancement (PRE) of the vertical drifts and the vertical shear in the zonal plasma drifts with implications for equatorial spread F.
Channel-independent recreation of artefactual signals in chronically recorded local field potentials using machine learning
Authors: Fabietti Marcos , Mahmud Mufti , Lotfi Ahmad 
Published: January 2022

AbstractAcquisition of neuronal signals involves a wide range of devices with specific electrical properties. Combined with other physiological sources within the body, the signals sensed by the devices are often distorted. Sometimes these distortions are visually identifiable, other times, they overlay with the signal characteristics making them very difficult to detect. To remove these distortions, the recordings are visually inspected and manually processed. However, this manual annotation process is time-consuming and automatic computational methods are needed to identify and remove these artefacts. Most of the existing artefact removal approaches rely on additional information from other recorded channels and fail when global artefacts are present or the affected channels constitute the majority of the recording system. Addressing this issue, this paper reports a novel channel-independent machine learning model to accurately identify and replace the artefactual segments present in the signals. Discarding these artifactual segments by the existing approaches causes discontinuities in the reproduced signals which may introduce errors in subsequent analyses. To avoid this, the proposed method predicts multiple values of the artefactual region using long–short term memory network to recreate the temporal and spectral properties of the recorded signal. The method has been tested on two open-access data sets and incorporated into the open-access SANTIA (SigMate Advanced: a Novel Tool for Identification of Artefacts in Neuronal Signals) toolbox for community use.
McKeown esophagectomy with concomitant median arcuate ligament release in a case of esophageal cancer with celiac artery stenosis
Authors: Hanada Keita , Tsunoda Shigeru , Ogiso Satoshi , Nishigori Tatsuto , Hisamori Shigeo , Obama Kazutaka 
Published: January 2022

Abstract
Background
The celiac artery stenosis due to compression by median arcuate ligament (MAL) has been reported in many cases of pancreaticoduodenectomy, but not in cases of esophagectomy. Recently, the celiac artery stenosis due to MAL or arteriosclerosis has been reported to be associated with the gastric tube necrosis or anastomotic leakage following Ivor–Lewis esophagectomy. Herein, we present the first reported case of esophageal cancer with celiac artery stenosis due to compression by the MAL successfully treated by McKeown esophagectomy and gastric tube reconstruction following prophylactic MAL release.

Case presentation
A 72-year-old female patient was referred to our department for esophagectomy. The patient had received two courses of neoadjuvant chemotherapy with 5-FU and cisplatin for T2N0M0 squamous cell carcinoma of the middle esophagus. Preoperative contrast-enhanced computed tomography (CECT) showed celiac artery stenosis due to compression by the MAL. The development of collateral arteries around the pancreatic head was observed without evidence of aneurysm formation. The patient reported no abdominal symptoms. After robot-assisted esophagectomy with mediastinal lymphadenectomy, gastric mobilization, supra-pancreatic lymphadenectomy, and preparation of the gastric tube were performed under laparotomy. Subsequently, the MAL was cut, and released to expose the celiac artery. Improved celiac artery blood flow was confirmed by decreased pulsatility index on intraoperative Doppler sonography. The operation was completed with the cervical esophagogastric anastomosis following cervical lymphadenectomy. Postoperative CECT on postoperative day 7 demonstrated increased celiac artery patency. The patient had an uncomplicated postoperative course thereafter.

Conclusions
Prophylactic MAL release may be considered in patients with celiac artery stenosis due to compression by the MAL on preoperative CECT for esophagectomy.
The racialization of expertise and professional non-equivalence in the humanitarian workplace
Authors: Bian Junru 
Published: January 2022

AbstractThis paper aims to explore the ways which expertise is covertly racialized in the contemporary humanitarian aid sector. While there are considerable discussions on the expat-local divide among aid professionals, such dichotomization is still inherently nationality-based, which may be an over-simplified explanation of the group dimensions within aid organizations. This study seeks to uncover that professional categorizations of “expatriate” and “local” are not race-neutral and, instead, colorblind. Organizations within the contemporary humanitarian aid apparatus have come to appeal to what Michael Omi and Howard Winant would characterize as a new racial discourse—one that does not require explicit references to race in order to be perpetuated, as racial subordination has been reconfigured to rely on implicit references to race woven within the everyday social fabrics of the humanitarian profession. The research suggests that embedded under the contemporary professional structure of the liberal humanitarian space is a covert power hierarchy fueled by perceptions of expertise and competency along racial lines—particularly around one’s whiteness.
Fatigue is associated with disease activity in some, but not all, patients living with rheumatoid arthritis: disentangling “between-person” and “within-person” associations
Authors: Versteeg Grada A. , ten Klooster Peter M. , van de Laar Mart A. F. J. 
Published: January 2022

Abstract
Background
Previous research has shown an unclear and inconsistent association between fatigue and disease activity in patients with rheumatoid arthritis (RA). The aim of this study was to explore differences in “between-person” and “within-person” associations between disease activity parameters and fatigue severity in patients with established RA.

Methods
Baseline and 3-monthly follow-up data up to one-year were used from 531 patients with established RA randomized to stopping (versus continuing) tumor necrosis factor inhibitor treatment enrolled in a large pragmatic trial. Between- and within-patient associations between different indicators of disease activity (C-reactive protein [CRP], erythrocyte sedimentation rate [ESR], swollen and tender joint count [ SJC and TJC], visual analog scale general health [VAS-GH]) and patient-reported fatigue severity (Bristol RA Fatigue Numerical Rating Scale) were disaggregated and estimated using person-mean centering in combination with repeated measures linear mixed modelling.

Results
Overall, different indices of disease activity were weakly to moderately associated with fatigue severity over time (β’s from 0.121 for SJC to 0.352 for VAS-GH, all p’s < 0.0001). Objective markers of inflammation (CRP, ESR and SJC) were associated weakly with fatigue within patients over time (β’s: 0.104–0.142, p’s < 0.0001), but not between patients. The subjective TJC and VAS-GH were significantly associated with fatigue both within and between patients, but with substantially stronger associations at the between-patient level (β’s: 0.217–0.515, p’s < 0.0001). Within-person associations varied widely for individual patients for all components of disease activity.

Conclusion
Associations between fatigue and disease activity vary largely for different patients and the pattern of between-person versus within-person associations appears different for objective versus subjective components of disease activity. The current findings explain the inconsistent results of previous research, illustrates the relevance of statistically distinguishing between different types of association in research on the relation between disease activity and fatigue and additionally suggest a need for a more personalized approach to fatigue in RA patients.
Trial registration Netherlands trial register, Number NTR3112.
Management of transitions to adult services for young people with eating disorders: survey of current practice in England
Authors: Winston Anthony P. , Child Samantha , Jackson Joseph , Paul Moli 
Published: January 2022

Aims and methodThe Royal College of Psychiatrists has published recommendations for managing transitions between child and adolescent mental health services (CAMHS) and adult services for eating disorders. A self-report questionnaire was designed to establish how many CAMHS teams meet these recommendations and was distributed to 70 teams providing eating disorders treatment in England.ResultsOf the 38 services that participated, 31 (81.6%) reported a flexible upper age limit for treatment. Only 6 services (15.8%) always transferred young people to a specialist adult eating disorders service and the majority transferred patients to either a specialist service or a community mental health team. Most services complied with recommended provision such as a written transition protocol (52.6%), individualised transition plans (78.9%), joint care with adult services (89.5%) and transition support for the family (73.7%).Clinical implicationsServices are largely compliant with the recommendations. It is a concern that only a small proportion of services are always able to refer to a specialist adult service and this is likely to be due to a relative lack of investment in adult services.
Suicidal ideations and suicide attempts prior to admission to a psychiatric hospital in the first six months of the COVID-19 pandemic: interrupted time-series analysis to estimate the impact of the lockdown and comparison of 2020 with 2019
Authors: Hörmann Christoph , Bandli Annatina , Bankwitz Anna , De Bardeci Mateo , Rüesch Annia , De Araujo Tania Villar , Seifritz Erich , Kleim Birgit , Olbrich Sebastian 
Published: January 2022

Background
There is a substantial burden on global mental health as a result of the Coronavirus disease 2019 (COVID-19) pandemic that has become putting pressure on healthcare systems. There is increasing concern about rising suicidality consequential to the COVID-19 pandemic and the measures taken. Existing research about the impact of earlier epidemics and economic crises as well as current studies about the effects of the pandemic on public mental health and populations at risk indicate rising suicidality, especially in the middle and longer term.

Aims
This study investigated the early impact of the COVID-19 pandemic on suicidality by comparing weekly in-patient admissions for individuals who were suicidal or who attempted suicide just before admission, for the first 6 months after the pandemic's onset in Switzerland with corresponding 2019 control data.

Method
Data was collected at the Psychiatric University Hospital of Zurich. An interrupted time-series design was used to analyse the number of patients who were suicidal.

Results
Instead of a suggested higher rate of suicidality, fewer admissions of patients with suicidal thoughts were found during the first 6-months after the COVID-19 outbreak. However, the proportion of involuntary admissions was found to be higher and more patients have been admitted after a first suicide attempt than in the corresponding control period from 2019.

Conclusions
Although admissions relating to suicidality decreased during the pandemic, the rising number of patients admitted with a first suicide attempt may be an early indicator for an upcoming extra burden on public mental health (and care). Being a multifactorial process, suicidality is influenced in several ways; low in-patient admissions of patients who are suicidal could also reflect fear of contagion and related uncertainty about seeking mental healthcare.
The mental health of NHS staff during the COVID-19 pandemic: two-wave Scottish cohort study
Authors: De Kock Johannes H. , Ann Latham Helen , Cowden Richard G. , Cullen Breda , Narzisi Katia , Jerdan Shaun , Muñoz Sarah-Anne , Leslie Stephen J. , McNamara Neil , Boggon Adam , Humphry Roger W. 
Published: January 2022

Background
Health and social care workers (HSCWs) are at risk of experiencing adverse mental health outcomes (e.g. higher levels of anxiety and depression) because of the COVID-19 pandemic. This can have a detrimental effect on quality of care, the national response to the pandemic and its aftermath.

Aims
A longitudinal design provided follow-up evidence on the mental health (changes in prevalence of disease over time) of NHS staff working at a remote health board in Scotland during the COVID-19 pandemic, and investigated the determinants of mental health outcomes over time.

Method
A two-wave longitudinal study was conducted from July to September 2020. Participants self-reported levels of depression (Patient Health Questionnaire-9), anxiety (Generalised Anxiety Disorder-7) and mental well-being (Warwick-Edinburgh Mental Well-being Scale) at baseline and 1.5 months later.

Results
The analytic sample of 169 participants, working in community (43%) and hospital (44%) settings, reported substantial levels of depression and anxiety, and low mental well-being at baseline (depression, 30.8%; anxiety, 20.1%; well-being, 31.9%). Although mental health remained mostly constant over time, the proportion of participants meeting the threshold for anxiety increased to 27.2% at follow-up. Multivariable modelling indicated that working with, and disruption because of, COVID-19 were associated with adverse mental health changes over time.

Conclusions
HSCWs working in a remote area with low COVID-19 prevalence reported substantial levels of anxiety and depression, similar to those working in areas with high COVID-19 prevalence. Efforts to support HSCW mental health must remain a priority, and should minimise the adverse effects of working with, and disruption caused by, the COVID-19 pandemic.
Patient-Reported Outcome-Based Symptom Management Versus Usual Care After Lung Cancer Surgery: A Multicenter Randomized Controlled Trial
Authors: Dai Wei , Feng Wenhong , Zhang Yuanqiang , Wang Xin Shelley , Liu Yangjun , Pompili Cecilia , Xu Wei , Xie Shaohua , Wang Yaqin , Liao Jia , Wei Xing , Xiang Run , Hu Bin , Tian Bo , Yang Xiaozun , Wang Xiang , Xiao Ping , Lai Qi , Wang Xin , Cao Bangrong , Wang Qifeng , Liu Fang , Liu Xiaoqin , Xie Tianpeng , Yang Xiaojun , Zhuang Xiang , Wu Zhong , Che Guowei , Li Qiang , Shi Qiuling 
Published: January 2022

PURPOSE We aimed to evaluate the efficacy and feasibility of patient-reported outcome (PRO)-based symptom management in the early period after lung cancer surgery. METHODS Before surgery, patients with clinically diagnosed lung cancer were randomly assigned 1:1 to receive postoperative PRO-based symptom management or usual care. All patients reported symptoms on MD Anderson Symptom Inventory-Lung Cancer presurgery, daily postsurgery, and twice a week after discharge for up to 4 weeks via an electronic PRO system. In the intervention group, treating surgeons responded to overthreshold electronic alerts driven by any of the five target symptom scores (score ≥ 4 on a 0-10 scale for pain, fatigue, disturbed sleep, shortness of breath, and coughing). The control group patients received usual care and no alerts were generated. The primary outcome was the number of symptom threshold events (any target symptom with a score of ≥ 4) at discharge. Per-protocol analyses were conducted. RESULTS Of the 166 participants, 83 were randomly allocated to each group. At discharge, the intervention group reported fewer symptom threshold events than the control group (median [interquartile range], 0 [0-2] v 2 [0-3]; P = .007). At 4 weeks postdischarge, this difference was maintained between the intervention and control groups (median [interquartile range], 0 [0-0] v 0 [0-1]; P = .018). The intervention group had a lower complication rate than the control group (21.5% v 40.6%; P = .019). Surgeons spent a median of 3 minutes managing an alert. CONCLUSION PRO-based symptom management after lung cancer surgery showed lower symptom burden and fewer complications than usual care for up to 4 weeks postdischarge.
Blood-Based Biomarker Panel for Personalized Lung Cancer Risk Assessment
Authors: Fahrmann Johannes F. , Marsh Tracey , Irajizad Ehsan , Patel Nikul , Murage Eunice , Vykoukal Jody , Dennison Jennifer B. , Do Kim-Anh , Ostrin Edwin , Spitz Margaret R. , Lam Stephen , Shete Sanjay , Meza Rafael , Tammemägi Martin C. , Feng Ziding , Hanash Samir M. 
Published: January 2022

PURPOSE To investigate whether a panel of circulating protein biomarkers would improve risk assessment for lung cancer screening in combination with a risk model on the basis of participant characteristics. METHODS A blinded validation study was performed using prostate lung colorectal ovarian (PLCO) Cancer Screening Trial data and biospecimens to evaluate the performance of a four-marker protein panel (4MP) consisting of the precursor form of surfactant protein B, cancer antigen 125, carcinoembryonic antigen, and cytokeratin-19 fragment in combination with a lung cancer risk prediction model (PLCOm2012) compared with current US Preventive Services Task Force (USPSTF) screening criteria. The 4MP was assayed in 1,299 sera collected preceding lung cancer diagnosis and 8,709 noncase sera. RESULTS The 4MP alone yielded an area under the receiver operating characteristic curve of 0.79 (95% CI, 0.77 to 0.82) for case sera collected within 1-year preceding diagnosis and 0.74 (95% CI, 0.72 to 0.76) among the entire specimen set. The combined 4MP + PLCOm2012 model yielded an area under the receiver operating characteristic curve of 0.85 (95% CI, 0.82 to 0.88) for case sera collected within 1 year preceding diagnosis. The benefit of the 4MP in the combined model resulted from improvement in sensitivity at high specificity. Compared with the USPSTF2021 criteria, the combined 4MP + PLCOm2012 model exhibited statistically significant improvements in sensitivity and specificity. Among PLCO participants with ≥ 10 smoking pack-years, the 4MP + PLCOm2012 model would have identified for annual screening 9.2% more lung cancer cases and would have reduced referral by 13.7% among noncases compared with USPSTF2021 criteria. CONCLUSION A blood-based biomarker panel in combination with PLCOm2012 significantly improves lung cancer risk assessment for lung cancer screening.
Turbulent transition in Rayleigh-Bénard convection with fluorocarbon
(a)
Authors: Méthivier Lucas , Braun Romane , Chillà Francesca , Salort Julien 
Published: January 2022

Abstract
We present measurements of the global heat transfer and the velocity field in two Rayleigh-Bénard cells (aspect ratios 1 and 2). We use Fluorinert FC770 as the working fluid, up to a Rayleigh number

. The velocity field is inferred from sequences of shadowgraph pattern using a Correlation Image Velocimetry (CIV) algorithm. Indeed the large number of plumes, and their small characteristic scale, make it possible to use the shadowgraph pattern produced by the thermal plumes in the same manner as particles in Particle Image Velocimetry (PIV). The method is validated in water against PIV, and yields identical wind velocity estimates. The joint heat transfer and velocity measurements allow to compute the scaling of the kinetic dissipation rate which features a transition from a laminar

scaling to a turbulent Re
3 scaling. We propose that the turbulent transition in Rayleigh-Bénard convection is controlled by a threshold Péclet number rather than a threshold Rayleigh number, which may explain the apparent discrepancy in the literature regarding the “ultimate” regime of convection.