bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary parameters in patients with drug allergy: Assessing dietary inflammatory index
Authors: Dias de Castro Eunice , Paredes Sílvia , Pinhão Sílvia , Cernadas Josefina R. , Ribeiro Laura 
Published: November 2022

BackgroundResearch on the increasing incidence of allergic diseases evidenced the role of diet as a potential key factor. Diet can modulate the low-grade systemic inflammation related to obesity and several diseases. There are no published data on drug allergy.AimTo investigate a potential association between diet, including dietary inflammatory index (DII), and drug allergy. Also, to evaluate correlations between diet and obesity, inflammatory and metabolic parameters in patients with drug allergy.MethodsNinety consecutive patients studied for suspected drug allergy were evaluated in terms of dietary parameters, anthropometric measurements, bioimpedance and biochemical analysis. DII was calculated based on information collected from a food frequency questionnaire.ResultsAfter diagnostic work-up, 39 patients had confirmed drug allergy and 45 excluded, representing the study group and the control group, respectively. The majority (79%) were female, with mean age of 39.58±13.3 years. The 84 subjects revealed an anti-inflammatory diet pattern. No significative difference was found in DII scores between drug allergic patients and controls (-3.37±0.95 vs -3.39±0.86, p = 0.985). However, the patients with drug allergy revealed higher obesity and inflammatory parameters. A significative negative correlation was found between DII and adiponectin levels, in the control group (r = -0.311, p = 0.040). In the patient group, a significative positive correlation was observed between DII and triglycerides (r = 0.359, p = 0.032). No other correlations were found between DII and the assessed parameters. Patients with drug allergy presented a significative higher intake of mono-unsaturated fatty-acids comparing to controls (19.8±3.7 vs 17.8 ± 4.0, p = 0.021). No other statistically significant differences were achieved in dietary parameters, between patients and controls.ConclusionThe population assessed in this study revealed an anti-inflammatory diet profile. Although we have found in a previous work that the same patients with drug allergy revealed higher obesity and inflammatory parameters, the DII did not allow to distinguish between patients with drug allergy or controls. The DII scores correlated with triglycerides levels in the drug allergy patients and inversely with adiponectin levels in the control group. Larger studies are needed to clarify the potential role of the diet in drug allergy and its outcomes.
Risk factors and outcome due to extended-spectrum β-lactamase-producing uropathogenic Escherichia coli in community-onset bloodstream infections: A ten-year cohort study in Sweden
Authors: Holmbom Martin , Möller Vidar , Kristinsdottir Loa , Nilsson Maud , Rashid Mamun-Ur , Fredrikson Mats , Berglund Björn , Östholm Balkhed Åse 
Published: November 2022

Objective
To study clinical outcome and risk factors associated with extended-spectrum β-lactamase (ESBL)-producing uropathogenic Escherichia coli (UPEC) in community-onset bloodstream infections (CO-BSI).

Methods
This was a population-based cohort study including patients with pheno- and genotype-matched ESBL-producing E. coli and non-ESBL- E. coli in urine and blood samples collected in 2009–2018 in southeast Sweden. Seventy-seven episodes of ESBL-UPEC satisfying the inclusion criteria were matched 1:1 with 77 non-ESBL-UPEC for age, gender, and year of culture.

Results
The most common ST-type and ESBL gene was ST131 (55%), and blaCTX-M-15 (47%), respectively. Risk factors for ESBL-UPEC were: previous genitourinary invasive procedure (RR 4.66; p = 0.005) or history of ESBL-producing E. coli (RR 12.14; p = 0.024). There was significant difference between ESBL-UPEC and non-ESBL-UPEC regarding time to microbiologically appropriate antibiotic therapy (27:15 h vs. 02:14 h; p = <0.001) and hospital days (9 vs. 5; p = <0.001), but no difference in 30-day mortality (3% vs. 3%; p = >0.999) or sepsis within 36 hours (51% vs. 62%; p = 0.623) was observed.

Conclusion
The predominant risk factors for ESBL-UPEC were history of ESBL-Ec infection and history of genitourinary invasive procedure. The overall mortality was low and the delay in appropriate antibiotic therapy did not increase the risk for 30-day mortality or risk for sepsis within 36 hours among patients infected with ESBL UPEC. However, these results must be regarded with some degree of caution due to the small sample size.
Cost-benefit analysis of a trifocal intraocular lens versus a monofocal intraocular lens from the patient’s perspective in the United States
Authors: Berdahl John , Bala Chandra , Dhariwal Mukesh , Rathi Hemant , Gupta Ritu 
Published: November 2022

Purpose
To conduct a cost-benefit analysis of AcrySof IQ PanOptix trifocal intraocular lens (TFNT00 IOL) versus AcrySof monofocal IOL (SN60AT) from the patient perspective in the United States (US).

Methods
A de novo Markov model was developed to estimate the mean total lifetime patient costs and vision-related quality of life (measured as quality adjusted life-years (QALYs)) with each intervention (TFNT00 and SN60AT) and the incremental differences between these two treatments. The resulting incremental quality of life gain was mapped to the US patient willingness to pay threshold of $50,000 per QALY gain to estimate the lifetime net monetary value, measured as the net monetary benefit of TFNT00 IOL. Model inputs (transition probabilities, costs, discount rate, utilities, and event rates) were derived from the FDA IDE study (NCT03280108), published literature, clinical experience, and other relevant sources.

Results
Bilateral cataract surgery with implantation of the advanced technology IOL (AT-IOL) TFNT00 provides improved vision-related quality of life (QALY gain of 0.67) at an incremental lifetime cost of $2,783 compared to monofocal IOL. This incremental QALY gain translated into a lifetime net monetary benefit of $30,941 at the patient willingness to pay threshold of $50,000/QALY gain. Results were most sensitive to disutility due to wearing glasses, patient out of pocket costs for bilateral AT-IOL procedure, and post-operative spectacle dependence rates.

Conclusions
AcrySof IQ PanOptix IOL provides greater improvement in vision related quality of life compared to no presbyopia correction with a monofocal IOL. This study shows PanOptix is a cost-beneficial treatment strategy for patients willing to pay out of pocket for cataract surgery.
Household composition and anxiety symptoms during the COVID-19 pandemic: A population-based study
Authors: McDonald André J. , Hamilton Hayley A. , Elton-Marshall Tara , Nigatu Yeshambel T. , Jankowicz Damian , Bondy Susan J. , Wells Samantha , Wickens Christine M. 
Published: November 2022

Introduction
Household composition may be an important factor associated with anxiety during the COVID-19 pandemic as people spend more time at home due to physical distancing and lockdown restrictions. Adults living with children–especially women–may be particularly vulnerable to anxiety as they balance additional childcare responsibilities and homeschooling with work. The objective of this study was to examine the association between household composition and anxiety symptoms during the COVID-19 pandemic and explore gender as an effect modifier.

Methods
Data were derived from seven waves of a national online survey of Canadian adults aged 18+ years from May 2020 to March 2021, which used quota sampling by age, gender, and region proportional to the English-speaking Canadian population (n = 7,021). Multivariable logistic and modified least-squares regression models were used.

Results
Compared to those living alone, significantly greater odds of anxiety symptoms were observed among single parents/guardians (aOR = 2.00; 95%CI: 1.41–2.84), those living with adult(s) and child(ren) (aOR = 1.39; 95%CI: 1.10–1.76), and those living with adult(s) only (aOR = 1.22; 95%CI: 1.00–1.49). Gender was a significant effect modifier on the additive scale (p = 0.0487) such that the association between living with child(ren) and anxiety symptoms was stronger among men than women.

Conclusion
Additional tailored supports are needed to address anxiety among adults living with children–especially men–during the COVID-19 pandemic and future infectious disease events.
Survival modelling and cost-effectiveness analysis of treatments for newly diagnosed metastatic hormone-sensitive prostate cancer
Authors: Barbier Michaela C. , Tomonaga Yuki , Menges Dominik , Yebyo Henock G. , Haile Sarah R. , Puhan Milo A. , Schwenkglenks Matthias 
Published: November 2022

Background
In metastatic hormone-sensitive prostate cancer (mHSPC) treatment, survival benefits have been shown by adding docetaxel or recent androgen receptor axis-targeted therapies (ARATs) abiraterone, apalutamide, or enzalutamide to androgen deprivation therapy (ADT). However, the optimal treatment strategy in terms of costs and effects is unclear, not least due to high ARAT costs.

Methods
To assess treatment cost-effectiveness, we developed a Markov cohort model with health states of progression-free disease, progressive disease and death for men with newly diagnosed mHSPC, with a 30-year time horizon. Survival data, adverse events and utilities were informed by randomized controlled trial results, our meta-analysis of re-created individual patient survival data, and publicly available sources of unit costs. We applied a Swiss healthcare payer perspective and discounted costs and effects by 3%.

Results
We found a significant overall survival benefit for ADT+abiraterone versus ADT+docetaxel. The corresponding incremental cost-effectiveness ratio (ICER) was predicted to be EUR 39,814 per quality-adjusted life-year (QALY) gained. ADT+apalutamide and ADT+enzalutamide incurred higher costs and lower QALYs compared to ADT+abiraterone. For all ARATs, drug costs constituted the most substantial cost component. Results were stable except for a large univariable reduction in the pre-progression utility under ADT+abiraterone and very large variations in drug prices.

Conclusions
Our model projected ADT+abiraterone to be cost-effective compared to ADT+docetaxel at a willingness-to-pay threshold of EUR 70,400/QALY (CHF 100,000 applying purchasing power parities). Given lower estimated QALYs for ADT+apalutamide and ADT+enzalutamide compared to ADT+abiraterone, the former only became cost-effective (the preferred) treatment option(s) at substantial 75–80% (80–90%) price reductions.
STUDY OF ANTIOXIDANT INDICATORS OF CHERRY FRUIT VARIETIES ZONED IN SVERDLOVSK REGION
Authors: Chugunova Ol'ga Viktorovna , Arisov Aleksandr Valer'yevich , Tiunov Vladislav Mikhaylovich , Vyatkin Anton Vladimirovich 
Published: November 2022

The article presents the results of a study of 11 varieties of cherry fruits released in the Sverdlovsk region. As a result of studies of antioxidant indicators, the highest values of antioxidant activity were, mmol/l equiv: in the period of early maturation – variety "Zadumka" – 31.995; in the period of medium ripening – the variety "Standard of the Urals" – 24.457; in the period of late ripening - variety "Alatyrskaya" – 30.610; the lowest value of the studied indicator in the variety "Flaming" – 7.799. At the same time, the highest content of flavonoids is observed in such varieties of cherry fruits as, mg / 100 g of the edible part, the "Zadumka" variety – 147.0±4.4, the “Ural Standard” variety – 112.4±3.4 and the variety "Alatyrskaya" – 140.6±4.2; the highest content of anthocyanins is observed in such varieties of cherry fruits as, mg cyanidin-3-glycoside / 100 g of edible part, variety "Zadumka" – 650.0±19.5, variety "Ural Standard" – 702.6±21.1 and promising variety "13-24" – 692.1±20.8; the highest content of phenolic substances is observed in such varieties of cherry fruits as, mg of gallic acid / 100 g of edible part, variety "Zadumka" – 51.6±1.6, variety "Mayak" – 75.9±2.3 and promising variety "13-24" – 93.2±2.8.
In addition, such consumer characteristics of berries as the content of total and reducing sugars, as well as acidity, were studied. The data obtained will make it possible to more correctly calculate the nutritional value of diets and reasonably choose one or another variety for dietary correction of the diet in order to increase the overall antioxidant activity.
Apresentação
Authors: Araújo Osmar Hélio Alves , Pacheco José Augusto , Corrêa Shirlei de Souza 
Published: November 2022

Dada a situação causada pelo Covid-19, a necessidade de mudanças nos currículos, no processo de avaliação, na formação de professores e na construção dos processos de ensino e aprendizagem, já anunciada em inúmeros estudos e pesquisas, ganhou novas proporções. Neste contexto, regras nunca antes vivenciadas, foram colocadas em práticas no contexto escolar. Assim, neste momento em que se vive ainda a Pandemia do Covid-19, os profissionais de educação têm enfrentado desafios e buscado alternativas para reinventar suas práticas, redescobrir suas habilidades e adaptar o currículo. Uma das melhores notícias que emerge desse contexto é a emergência, em todo o mundo, de se (re)construir a Escola hoje e reafirmar seu compromisso público com a democratização e o acesso à educação. (Re)pensar o presente, (re)definir novos rumos ou (re)descobrir novos jeitos de caminhar ((RE)CONSTRUIR A ESCOLA HOJE) é um dos desafios que vêm sendo enfrentado pelos profissionais de educação, pais e sociedade em geral, sobretudo neste momento em que a escola precisa (cor)responder aos desafios dos dias atuais, como são, por exemplo, a efetivação dos processos de ensino e aprendizagem por meio das aulas remotas e, ainda, a busca de alternativas para democratizar o acesso à Educação Remota. É nesse contexto que se insere o dossiê: A ESCOLA NOS DIAS ATUAIS: E AGORA? e que reuni 11 estudos e pesquisas e 02 entrevistas sobre a Escola, neste contexto de enfrentamento à pandemia do Covid-19, e, assim, discute sobre o presente no sentido de (re) descobrir - quem sabe - outros jeitos de construir a educação.
THE EXISTENCE OF PANCASILA IN RESOLVING CONFLICTS OF DIFFERING VIEWS ON RELIGIOUS RIGHTS IN INDONESIA
Authors: Herlindah Herlindah , Qurbani Indah Dwi , Prisilia Dorra 
Published: November 2022

This research investigates how Pancasila (the Five Principles) could serve as an equilibrium in regulating the freedom of religion in Indonesia and how these five principles could negotiate the concept of this freedom within the coverage of national Human Rights affected by western human rights related to the concept of the freedom of religions within the scope of Islam. The three different regulatory concepts regarding freedom of religion in Indonesia, constituting Islamic law, International Human Rights, and Particular Human Rights, have always sparked conflict unless these three concepts are accommodated by law. The analysis was performed by employing the doctrine of margin of appreciation. This research reveals that Pancasila could serve as the fundamental of Indonesia in facilitating the freedom of religion. This research also employed a normative-juridical method, interdisciplinary, statutory, and conceptual approaches.
Strategies for establishing discourse coherence. The case of Slovene dialectal discourse
Authors: Zuljan Kumar Danila 
Published: November 2022

Abstract
A discourse is considered coherent only if all its parts are semantically related to each other and if it makes sense. However, coherence cannot be attributed to a discourse in advance because it depends on how the participants understand what they hear/ read. So we can say that it is not the discourse that establishes coherence, but the participants according to their understanding of a discourse. In practise, this means that for the same discourse there are at least two coherences that may or may not match up. Usually they match up to some extent because participants follow the cooperative principle of mutual willingness to establish coherence in discourse.
There are several strategies for establishing and maintaining discourse coherence; among them, repetition and inference form an extensive group. In this paper, however, I will focus only on the strategies that are typical of spontaneous spoken discourse. These are the following: questions, completion, contradiction and polyphonic talk.
In the second part of the article I will present each of them in the examples of spontaneous dialectal discourse. The texts were recorded in Brda, a region in the far west of Slovenia. The dialect spoken there is called the Brda dialect. It belongs to the Littoral dialect group of the Slovene language.
Real time and memory time of “father”. Social and linguistic motivation observed in Glottograms
Authors: Inoue Fumio , Hanzawa Yasushi , Tanabe Kazuko , Yamashita Akemi 
Published: November 2022

Abstract
This paper introduces the concept of “memory time” and gives an overview of its application to dialect forms that refer to “father”. Changes in many regions are shown by glottograms that simultaneously show regional and generational differences. The usage of kinship terms in Japanese shows interesting sociolinguistic features. It is linked to the consciousness of attribution to a specific social class. Due to the agricultural land reform after the war, the difference in social hierarchy within the rural areas became smaller, but the distinction or disparity made by kinship terms remained. Although the agricultural land reform was carried out all over the country at the same time, the standard form o-too-san for “father” gradually spread throughout the country in the latter half of the 20th century. The diffusion pattern is similar to other standard forms. From the above, it can be concluded that the standard form otoo-san was not directly influenced by changes in social stratification, but was the spread of standard language only in words without social-class background. The ultimate mechanism of change was found to be the “law of respect reduction”.
Efficacy of rectal progesterone on maternal and neonatal outcomes in pregnant women with Preterm Premature Rupture of membranes: a triple-blind randomised clinical trial
Authors: Vosoogh Shohre , Zanganeh Marzieh , Gonabadi Behnaz 
Published: November 2022

Abstract

Objectives
This study was conducted to evaluate the efficacy of rectal progesterone suppositories on pregnancy outcomes of pregnant women diagnosed with PPROM at the gestational age of 26–34 weeks, as well as on maternal and neonatal outcomes.

Methods
This is a double-blind, randomized clinical trial in pregnant women with PROM with gestational age of 26–24 weeks, conducted between February 2020 and December 2020 in Sayyad Shirazi Hospital, Gorgan, Iran.

Results
According to the results of the present study; Rectal progesterone suppository in pregnant women with PPROM is associated with improved delivery outcomes such as neonatal APGAR score, increased latent delivery stage without complications or severe and dangerous complications, without increased risk of mortality and NICU hospitalization in infants, so prescribing suppository rectal progesterone in pregnant women with PPROM with a gestational age of 26 to 34 weeks is associated with positive outcomes and is recommended based on the findings and opinions of the researchers.

Conclusions
According to the results of the present study; Rectal progesterone suppository in pregnant women with PPROM is associated with improved delivery outcomes such as neonatal APGAR score, increased latent delivery stage without complications or severe and dangerous complications, without increased risk of mortality and NICU hospitalization in infants, so prescribing suppository rectal progesterone in pregnant women with PPROM with a gestational age of 26 to 34 weeks is associated with positive outcomes and is recommended based on the findings and opinions of the researchers.
Hydrothermal synthesis of CoAl2O4 spinel: effect of reaction conditions on the characteristic and morphological features
Authors: Senberber Dumanli Fatma Tugce , Moroydor Derun Emek 
Published: November 2022

Abstract
The spinel form of cobalt aluminate (CoAl2O4) was synthesized by a hydrothermal method in moderate conditions. The synthesized phases were qualitatively and quantitively identified by means of different characterization techniques. The effects of reaction conditions of Co/Al ratio, pH, stirring time, reaction temperature, reaction time and capping agent addition on the color performance and morphology were studied. The capping agents of n-cetyl-n, n, n trimethylammonium bromide (CTAB), 2-pyrrolidinone (PVP), triethylamine (TEA) and oleic acid (OA) were used. The probable reaction mechanism can be explained with the steps of (i) formation of Co–Al–O complexes and (ii) conversion to Co-spinel. In the reaction mechanism, the addition of capping agents improved the conversion of complexes to Co-spinel. The characteristic band values were observed at 550, 595 and 650 nm in the ultraviolet–visible wavelength range, in UV analyses. The lowest b* and the highest BET surface area were determined in the TEA added sample with values of – 37.4 and 16.02, respectively. Layer shaped particles were obtained in CTAB added samples whereas the angled cubic particles were seen in the TEA and OA added samples. The smallest particles were observed in the use of PVP addition to spinel, and the particle size was around 100 nm. The experimental results proved that characteristic properties of prepared samples can be enhanced by the selection of a suitable capping agent.
Mechanical response of paperboard to rapid compression
Authors: Yang Li 
Published: November 2022

Abstract
ZD-tester is a measurement technique for rapid compression in Z-direction. The strain rate of compression of this device is far beyond the ordinary mechanical testing methods applied in papermaking industries. Thus, it provides insights to the material responses which are relevant to industrial applications, e. g. calendaring, printing, etc where the strain rate ranges from hundreds to thousands per second. A physics model that describes the dynamic process of the probe has been developed, where a linear Maxwell model is used to account for the viscoelasticity of paperboard. The simulation has successfully reproduced both the general features and quantitative details of the experiment. The model reveals that the ratio of the elastic modulus to the viscosity modulus of the material governs the amplitude attenuation while the angular frequency of the striking-rebounding cycle depends mainly on the elastic modulus. The dropping height determines the initial striking velocity but has no direct impact on either attenuation or angular frequency. The model and simulation provided interpretations of both experimental observations and dynamic behaviours of the material. With help of simulation, the impacts of the individual parameters, e. g. the Young’s modulus, E, the viscosity modulus, η, and the drop height, H, were also explored.