bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengujian Akuifer Sumur Produksi untuk Memenuhi Kebutuhan Pabrik Pengolahan Zircon
Authors: Muhammad Abizard Rizki  , Yunus Ashari  , Indra Karna Wijaksana  
Published: September 2022

Abstract. PT. X is a company engaged in the processing of zircon mining materials. In the processing process, it uses a water supply that only comes from groundwater. Groundwater sources at PT. X come from three drilled wells and each well is tested to determine the characteristics of the aquifer and the optimum discharge value. The research was conducted using the method pumping test, Pumping The test is divided into three stages, namely step drawdown test, constant rate test and recovery test. In the stages, the drawdown test and constant rate test groundwater level reduction value is obtained with a certain discharge, while the recovery test obtains the groundwater level recovery value. The results of the pumping test get the optimum discharge value from each well which is 10.6 lt/s for SB-01, 6.2 lt/s for SB-02, and 10.6 lt/s for SB-03, pumping with the optimum discharge into the safe category based on the regional regulation on groundwater damage criteria, West Java Provincial Regulation Number 1 of 2017 concerning the criteria for groundwater damage.
Abstrak. PT. X merupakan perusahaan yang bergerak pada bidang pengolahan bahan tambang zircon. dalam proses pengolahannya menggunakan pasokan air yang hanya berasal dari airtanah. Sumber airtanah di PT. X berasal dari tiga sumur bor dan masing-masing sumur tersebut di uji untuk mengetahui bagaimana karakteristik akuifer dan nilai debit optimum. Penelitian dilakukan dengan metode pumping test, Pumping test terbagi menjadi tiga tahap yaitu step drawdown test, constant rate test dan recovery test. Pada tahapan drawdown test dan constant rate test mendapatkan nilai penurunan muka air tanah dengan debit tertentu, sedangkan recovery test mendapatkan nilai pemulihan muka air tanah. Hasil dari pumping test mendapatkan nilai debit optimum dari masingmasing sumur yaitu sebesar 10,6 lt/det untuk SB-01, 6,2 lt/det untuk SB- 02, dan 10,6 lt/det untuk SB-03, pemompaan dengan debit optimum masuk kedalam kategori aman berdasarkan perda kriteria kerusakan muka airtanah Perda Provinsi Jawa Barat nomor 1 tahun 2017 tentang kriteria kerusakan muka airtanah.
A clinical case of linear stromal (interstitial) keratitis
Authors: Direev A. O. , Chernykh V. V. 
Published: September 2022

Background. Keratitis, characterized by superficial inflammation, cellular infiltration and vascularization of the stroma with minimal involvement of the corneal epithelium and endothelium, is an extremely rare specific condition, that has been isolated, as a separate nosology – linear interstitial keratitis.The aim. Clinical case demonstration of linear stromal keratitis, using modern methods of corneal examination and world literature analysis, devoted to this problem, from the point of view of determining disease etiology.Materials and methods. Case demonstration of linear keratitis in a young patient with a recurrent course of the disease is presented.Results. Рresented clinical case confirms course features and lesion morphology of linear interstitial keratitis.Conclusion. Linear interstitial keratitis is a rare clinical phenomenon, and its etiology remains uncertain. Confocal microscopy is a promising method of studying linear interstitial keratitis in view of best resolution. Coherent tomography of anterior segment of the eye, is uninformative and does not reflect true depth of the pathological process. Mirror microscopy of endothelial cells confirms confocal microscopy data of panstromic process. Herpes simplex virus and pale treponema roles in the development of linear interstitial keratitis has not been confirmed by existing standard laboratory methods.
Pathological damage of thyroidopathy and the prevalence of thyroid diseases in children of the Perm region
Authors: Shtina I. E. , Valina S. L. , Ivashova Yu. A. , Ustinova O. Yu. , Eisfeld D. A. 
Published: September 2022

Relevance. Thyroid diseases in children and adolescents rank first in the structure of endocrine pathology. An issue related to comparability of data on prevalence obtained with different procedures is vital given the necessity to intensify activities aimed at optimizing prevention of thyroid pathology.The aim. Comparative analysis of pathological lesions of thyropathies and the prevalence of thyroid gland diseases in children and adolescents living in the territory of the Perm region.Materials and methods. Prevalence of thyroid diseases was analyzed based on data taken from Statistic Form No. 12. Pathological damage caused by thyroid diseases was calculated based on results produced by medical examinations that included laboratory tests, ultrasound scanning of the thyroid gland, and a check-up by an endocrinologist. Calculation results were then compared with data taken from statistic reports. Influence exerted by sex and age on the growth in thyrotrophic hormone contents and thyroid gland volume was assessed by analyzing values in one-factor logistic regression models.Results. Prevalence of thyroid diseases, endemic goiter and subclinical hypothyroidism tends to decrease among children living in Perm region (р = 0.003–0.015) but prevalence of thyroiditis remains stable (р = 0.794). Having assessed prevalence among teenagers, we did not reveal any dynamics in prevalence of thyroid diseases and thyroiditis (р = 0.129–0.248); prevalence of endemic goiter went down in this age group (р = 0.008) whereas prevalence of subclinical hypothyroidism grew due to iodine deficiency (р = 0.012). The difference between pathological damage and prevalence of thyroid diseases reached 4.8–38.6 times. Having analyzed created logistic models, we were not able to identify sex or age as predictors of thyroid pathology occurrence.Conclusion. Prevalence of thyroid pathology was established to be by 4.8–38.6 times lower than pathological damage. Iodine deficiency on a given territory calls for developing regional medical and prevention programs aimed at diagnosing and preventing thyroid diseases caused by it.
Features of the organization of coloproctological care to the population taking into account regional indicators of incidence
Authors: Lisichkin A. L. , Sandakov Ya. P. 
Published: September 2022

Rationale. The article provides an analysis of the features of the organization of coloproctological care for the population of the Perm Territory, taking into account regional morbidity rates, which made it possible to identify a number of significant shortcomings. There is no connection between the volume of specialized coloproctological care provided and the real need of the population. It was revealed that 32.0 % of coloproctological patients are being treated by doctors of other specialties. In 2018, 47,172 cases of coloproctological diseases were registered, and only 30,900 specialized outpatient appointments were made in the region (11.7 appointments per 1,000 population). More than half of them (57.4 %) were held in Perm.The aim of the study. Determination of the features of the organization of coloproctological care for the population of the Perm Territory, considering the incidence rates.Materials and methods. An analysis was made of the distribution among the adult population of the Perm Territory of pathologies related to the profile of coloproctology according to official statistical reports and the report of the chief specialist of the region for 2018.Results. In 2018, 3.9 sigmoidoscopies per 1,000 population were performed and 1.7 fibrocolonoscopies per 1,000 population, which led to an insufficient level of diagnosis of coloproctological pathologies. At the same time, identified for the period 2004–2018, a significant increase in the incidence of colorectal cancer (by 48.1 %), with an average annual growth rate over 15 years of 7.8 %, which is 3 times higher than the national figure, requires a change in approaches to the organization of coloproctological care, incl. for early diagnosis.Conclusion. Thus, in order to improve the quality of early diagnosis of coloproctological, and especially onco-coloproctological diseases, it is required to optimize the outpatient specialized coloproctological care in the Perm region. It is proposed to reorganize the service with the aim of organizing a primary link on the basis of an outpatient coloproctology center with a daily stay hospital, separate or at the coloproctology department of the City Clinical Hospital.
The functional status of forestry industry workers in the Far North during the shift period
Authors: Korneeva Ya. M. , Simonova N. N. , Korneeva A. V. , Trofimova A. A. 
Published: September 2022

All over the world, the timber industry is one of the most physically hazardous industries. Working in such conditions is accompanied by an increase in the risk of unfavorable functional states and a critical decrease in professional reliability. Monitoring the workers’ state during the shift period will allow to determine the adaptation degree of personnel to work, as well as to identify the days of the shift arrival with a high risk of injury caused by the unfavorable state of workers.The aim.To identify and describe the functional states dynamics of loggers during the entire shift period in the Far North as their adaptation degree to work.Methods.Objective: collection of saliva for the determination of cortisol, psychophysiological instrumental methods; projective: M. Luscher’s color test; subjective – questionnaire “Well-being. Activity. Mood” by V.А. Doskin et al.; statistical methods: descriptive statistics. The study involved 24 shift workers of a logging enterprise, with whom we conducted daily monitoring of objective, projective and subjective characteristics of their functional state in the morning and evening during a fourteenday shift visit.Results.According to the objective, projective and subjective indicators of functional states, their consistently favorable level is observed with multidirectional peaks during the shift change period and a slight decrease at the end of the shift, which demonstrates the staff’ adaptability to work. The operator performance is somewhat higher in the second half of the shift period, but in general it is below average due to the reduced quality of task performance. An increased free cortisol level was revealed in employees during the entire shift period with a high functional reserves level of the body. During the shift change period, the risks associated with the efficiency and safety of labor increase, which undoubtedly requires consideration by the management of enterprises.
Adults with typical and atypical development: Aspects of self-realization
Authors: Shipova N. S. , Opekina T. P. 
Published: September 2022

The desire to realize oneself is characteristic of people, regardless of the state of health.The scientific problem is based on the need to study the conditions, resources and psychological consequences that ensure self-realization of persons with atypical development in comparison with typically developing people.The aim of the study. To analyze the specifics of self-realization of people with typical and atypical development, its resources and consequences.Methods. The sample included 93 people with normative and impaired development (impaired vision, hearing, musculoskeletal system, somatic diseases). Questionnaire methods were used: the test of judgments of self-realization of the personality by S.I. Kudinov; hardiness test of S. Maddi, D.A. Leontiev and E.I. Rasskazova; scale of subjective happiness by S. Lubomirsky and H. Lepper (adapted by D.A. Leontiev and E.N. Osin); scale of subjective well-being A. Perrudet-Badoux (adapted by M.V. Sokolova); self-compassion scale by K. Neff (adapted by K.A. Chistopolskaya et al.); scale of subjective vitality R.M. Ryan and S. Frederick (adapted by L.A. Alexandrova); coping strategies evaluation questionnaire COPE by C. Carver et al. (adapted by T.O. Gordeeva et al.); as well as an author’s interview.Results. Characteristics of self-realization of persons with typical and atypical development do not have significant differences. Subjects with developmental disorders are more likely to be pessimistic in the context of self-realization. The most successful areas of self-realization for people with atypical development are personal growth and family relationships. In areas related to contacts with the external environment (study, leisure, interpersonal interaction), people with typical development are more realized. The specifics in the aspects of self-realization, components of resilience, subjective well-being, sympathetic attitude towards oneself and preferred coping strategies are revealed.Conclusion. There is specificity in the aspects of self-realization, its resources and consequences in people with typical and atypical development.
The role of some lipids and their metabolites in programmed cell death (lipoapoptosis).
Authors: Ishutina N. A. , Andrievskaya I. A. 
Published: September 2022

In recent years, the understanding of the mechanisms involved in the regulation of lipoapoptosis signaling pathways has expanded considerably. However, many mechanisms of apoptosis induction by lipids as well as molecules mediating intracellular and systemic signals belonging to AOS/enzyme-dependent phospholipid metabolites are not completely clear.This review summarizes the current understanding of the mechanisms of apoptotic cell death induction by some lipid molecules. Literature search was performed in the database “PubMed”, “eLIBRARY” using key words: “apoptosis”, “lipids”, “fatty acids”, “eicosanoids”, “reactive oxygen species”.A brief characterization of the signaling pathways of apoptosis is given. The role of reactive oxygen species and their dependent products of lipid peroxidation in the regulation of the main signaling pathways of apoptosis are shown. Particular attention is paid to the product of phospholipid metabolism – 4-hydroxynonenal.Pro- and anti-apoptotic effects of some prostaglandins are demonstrated. Arguments are presented that prostaglandins of series J and D are pro-apoptotic in most cells, and this effect depends on activation of the prostanoid receptor DP2 and on reduction of AKT kinase activity. In contrast, the E-series prostaglandins and hydroxyecosatetraenoic acid act opposite to the J-series and D-series prostaglandins, reducing apoptosis by activating AKT and increasing Bcl-2 protein expression.The role of individual fatty acids involved in the initiation and transduction of pro-apoptotic and anti-apoptotic signals is assessed. It was shown that saturated fatty acids have the maximum damaging potential than their unsaturated counterparts. An in-depth understanding and deciphering of the mechanisms by which lipids and their metabolites modulate the activation of signaling pathways of programmed cell death can help to develop therapeutic strategies to prevent a number of diseases associated with impaired regulation of apoptosis.
Use of biodegradable polycaprolactone matrix for filling bone defects (experimental study)
Authors: Popkov A. V. , Gorbach E. N. , Kononovich N. A. , Tverdokhlebov S. I. , Bolbasov E. N. , Popkov D. A. , Gorbach E. S. 
Published: September 2022

Background. There are unresolved issues in bone defect management associated with complications, invasiveness and long duration of treatment. The use of elastic implants made of bioactive biodegradable materials that take any form of defect could close many of them.The aim. To investigate features of reparative regeneration in filling bone defects with an elastic degradable implant made of polycaprolactone (PCL) with and without hydroxyapatite (HA).Materials and methods. The study was carried out on 10 adult mongrel dogs. A non-through cylindrical hole, 4 mm in diameter and 10 mm deep, was modeled in the upper third of the diaphysis of the tibia. The defects thus formed were filled with an elastic degradable implant made of polycaprolactone. In Group 1, HA was not added to polycaprolactone, while HA was added in dogs of Group 2. Radiographic and histological methods were used to study the results.Results. It was found that the tested materials did not cause toxic and allergic reactions, both local and general, during intravital observations and in post-mortem anatomical preparations. After 28 days in both series, the implant biodegraded and was replaced by bone tissue. The proportion of the bone component and the numerical density of microvessels in the defect zone in Group 2 were significantly higher than in Group 1.Conclusion. Elastic implants produced of polycaprolactone by electrospinning are biologically compatible, biodegradable and can be used to heal bone defects. Hydroxyapatite that was added stimulates the activity of osteogenesis.
Nanоbiocomposite based on dihydroquercetin and arabinogalactan in the form of a gel for external use as a means for the treatment of chronic venous insufficiency in an experiment
Authors: Kovalskaya G. N. , Kolmakova E. S. , Nikiforov S. B. , Lozovskaya E. A. , Artemieva A. V. 
Published: September 2022

Background. Due to the high prevalence of chronic venous insufficiency among the population, with a decrease in the quality of life of patients and their early disability, there is a need to develop modern effective and safe means for the prevention and treatment of this pathology. We have developed the optimal composition and technology of a gel for external use based on a nanobiocomposite of dihydroquercetin and arabinogalactan, which has a venoprotective effect. The article presents data on the results of a preclinical study of the safety and specific activity of the gel.The aim. To study the specific activity (decongestant, antitranssudative action) and safety of a gel for external use based on nanobiocomposite of dihydroquercetin and arabinogalactan used for the treatment of chronic venous insufficiency in the framework of preclinical studies.Materials and methods. The object of the study was a gel for external use based on dihydroquercetin and arabinogalactan nanobiocomposite. The study was conducted on 32 white male rats of the same age, for 15 days. The study of the pharmacological activity of a gel based on a nanobiocomposite of dihydroquercetin and arabinogalactan, was carried out on a model of acute venous stagnation in the tail of a rat (edema of non-inflammatory genesis), the dynamics of tail volume growth in the experimental and control group of animals was evaluated. The irritant effect of the gel on the skin of animals was also determined, the permeability of the capillaries of the skin was determined.Results. When studying the pharmacological activity of the gel on a model of acute venous stagnation in the tail, it was shown that a soft dosage form for external use developed on the basis of nanobiocomposite of dihydroquercetin and arabinogalactan has decongestant and antitranssudative activity. The presence of a locally irritating effect in the gel under study has not been established in the framework of the experiment.Conclusion. In the course of preclinical study of the gel of the nanobiocomposite dihydroquercetin and arabinogalactan on laboratory animals, its antitranssudative activity and safety have been proven.
Analysis of intra annual spatial dynamics of community-aсquired pneumonia incidence in the urban environment
Authors: Kravchenko N. A. , Galyos D. A. , Khakimova M. I. , Botvinkin A. D. 
Published: September 2022

Background. The spread of community-acquired pneumonia (CAP) in children and adults is interconnected and conditioned by natural, climatic and social factors.The aim. To assess the relationship between the incidences of CAP in different seasons of the year with the location of educational institutions in the urban settlement.Materials and methods. A cross-sectional study of the spatial distribution and seasonal dynamics of CAP cases in 2015 in a Siberian city with a population of more than 600 thousand people was carried out. Using GIS, 787 cases of CAP were analyzed among children of preschool and school age and adults. For statistical processing, 111 analyzed territorial units (ATUs) with an area of 250 m2 each were allocated on the maps. The dynamics of morbidity was assessed by weeks and seasons of the year among different age groups.Results. There was a direct moderate correlation between the number of CAP cases registered during the year with the number of schools and preschool educational institutions in ATU (r = 0.59; p < 0.001). ATUs with the presence and absence of educational institutions differed in the number of epidemic foci of CAP among the total population in winter and spring. The maximum number of cases of CAP among children and adults was registered in the second half of winter (weeks 3–13), the minimum – in the summer months (weeks 25–34).Conclusions. GIS analysis confirms the more frequent registration of CAP diseases among the total population in urban areas with educational institutions. There was established a direct moderate correlation between the incidence of CAP in children and adults by weeks of the year. Statistically significant differences in the number of cases in areas with and without educational institutions were noted in seasons with a higher incidence (autumn and winter).
Chronic scrotal pain: Pathogenesis, clinical phenotypes and modern treatment concept (clinical lecture)
Authors: Lelyavin K. B. 
Published: September 2022

Chronic scrotal pain (CSP) is a general term, which defines variety of problems causing discomfort or pain in the scrotum, which can be caused by the problems with testicles and other structures of the scrotum: epididymis, vas deferens, paratesticular structures. For a practicing urologist, the diagnosis and treatment of chronic scrotal pain is always a difficult task due to the many reasons for its appearance and the variety of clinical symptoms. CSP is a widespread but poorly understood condition, the etiology of which often can not be identified. Pain localized in the scrotum makes up 38.8 % of all cases of chronic men’s pelvic pain. From 2.5 to 4.8 % of all visits to the urologist relate to CSP syndrome. Primary scrotal pain syndrome is not associated with infection or other local pathological processes that could cause pain. The treatment of chronic scrotal pain is challenging because the pain often does not react to the traditional treatments.The purpose of this lecture is to draw the attention of urologists, general practitioners, and everyone who is interested in the problem of treating chronic scrotal pain to the possibilities of modern medicine in solving this multidisciplinary problem.