bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipid-Lowering Therapy Use and Intensification Among United States Veterans Following Myocardial Infarction or Coronary Revascularization Between 2015 and 2019
Authors: Zheutlin Alexander R. , Derington Catherine G. , Herrick Jennifer S. , Rosenson Robert S. , Poudel Bharat , Safford Monika M. , Brown Todd M. , Jackson Elizabeth A. , Woodward Mark , Reading Stephanie , Orroth Kate , Exter Jason , Virani Salim S. , Muntner Paul , Bress Adam P. 
Published: October 2022

Background:
Understanding how statins, ezetimibe, and PCSK9i (proprotein convertase subtilisin/kexin type 9 serine protease inhibitors) are prescribed after a myocardial infarction (MI) or elective coronary revascularization may improve lipid-lowering therapy (LLT) intensification and reduce recurrent atherosclerotic cardiovascular disease events. We described the use and intensification of LLT among US veterans who had a MI or elective coronary revascularization between July 24, 2015, and December 9, 2019, within 12 months of hospital discharge.

Methods:

LLT intensification was defined as increasing statin dose, or initiating a statin, ezetimibe, or a PCSK9i, overall and among those with an LDL-C (low-density lipoprotein cholesterol)
≥
70 or 100 mg/dL. Poisson regression was used to determine patient characteristics associated with a greater likelihood of LLT intensification following hospitalization for MI or elective coronary revascularization.

Results:

Among 81 372 index events (mean age, 69.0 years, 2.3% female, mean LDL-C 89.6 mg/dL, 33.8% with LDL-C <70 mg/dL), 39.7% were not taking any LLT, and 22.0%, 37.2%, and 0.6% were taking a low-moderate intensity statin, a high-intensity statin, and ezetimibe, respectively, before MI/coronary revascularization during the study period. Within 14 days, 3 months, and 12 months posthospitalization, 33.3%, 41.9%, and 47.3%, respectively, of veterans received LLT intensification. LLT intensification was most common among veterans taking no LLT (82.5%, n=26 637) before MI/coronary revascularization. Higher baseline LDL-C, having a lipid test, and attending a cardiology visit were each associated with a greater likelihood of LLT intensification, while age
≥
75 versus <65 years was associated with a lower likelihood of LLT intensification within 12 months posthospitalization.

Conclusions:
Less than half of veterans received LLT intensification in the year after MI or coronary revascularization suggesting a missed opportunity to reduce atherosclerotic cardiovascular disease risk.
Rouzhi 柔知 “the Supple Way of Knowing”: Cognitive Traps and Embodied Intellectual Virtues
Authors: Wang Robin R. 
Published: October 2022

Abstract
This essay explores the epistemological implications of the Daoist concept of rou 柔 or “suppleness” and its related notion rouzhi 柔知 or the “supple way of knowing.” It is comprised of three interrelated parts. Part one starts with a brief introduction to rou and its usage in early Chinese texts, where it outlines three important ways to approach it. In part two, it moves to a careful reading of female Daoist Cao Wenyi’s 曹文逸 Lingyuan Dadaoge 《靈源大道歌》 (The Song of the Ultimate Source of Great Dao or Dadaoge for short), where it explores her text as formulating a Daoist way of knowing based on an appreciation of rou. The third section discusses concrete connections between rou and specific epistemic virtues.
Kang Youwei on the Subjection of Women
Authors: Jiang Xinyan 
Published: October 2022

Abstract
This paper examines Kang Youwei’s view of sexual equality based on the study of his The Book of the Great Unity (Da Tong Shu 《大同書》). The paper shows that Kang’s critique of the subjection of women is the most systematic, profound, and fierce in the history of modern Chinese philosophy. Although his theory of the oppression of women and sexual equality is essentially the combination of liberalism, utilitarianism, and socialism, his work on the subject should be given a special place in modern feminist philosophy. Unlike Western feminist thinkers, Kang understood the suffering of oppressed women in non-Western countries, especially in China, and spoke out for them in a way that no one did before. The volume on women’s oppression and liberation in The Book of the Great Unity could be regarded as a book on the subjection of women in developing countries crossing cultures and religions.
Do ruminants and hindgut fermenters differ in their activity? Comparison of syntopic black wildebeest and Cape mountain zebra
Authors: Forbes Ryan E. , Kerley Graham I.H. 
Published: October 2022

Abstract
Optimally foraging animals should minimise time spent foraging in order to perform other fitness-enhancing activities. The ruminants’ more efficient digestive system, requiring lower volumes of forage, is predicted to provide an advantage over hindgut fermenters with respect to foraging effort, but this may be offset by their need for higher quality forage. We contrasted the activity of two similarly-sized, syntopic grazers, black wildebeest (Connochaetes gnou), a ruminant, and Cape mountain zebra (Equus zebra zebra), a hindgut fermenter, using camera trap data and tested the volume-requirement and the nutrient-driven hypotheses, seasonally. Zebra and wildebeest activity varied seasonally, potentially due to differences in resource availability. In winter, a greater proportion of wildebeest were recorded grazing relative to zebra, supporting the nutrient-driven hypothesis, whilst the inverse occurred (although not significantly) in summer, supporting the volume-requirement hypothesis. Seasonal variation in resources may provide temporal foraging trade-offs of benefits for ruminants and hindgut fermenters.
The Prospects of an International Treaty on Plastic Pollution
Authors: Stöfen-O’Brien Aleke 
Published: October 2022

Abstract
On 2 March 2022, the United Nations Environment Assembly to the United Nations Environment Program (UNEP) requested the Executive Director of UNEP to convene an international negotiating committee towards the negotiation of an international legally binding instrument on plastics by 2024. This article examines some of the proposed elements of such an instrument and outlines the next steps that can be expected in the negotiations. It also reflects on the results of the ad hoc open-ended working group to prepare for the work of the intergovernmental negotiating committee to develop an international legally binding instrument on plastic pollution, including in the marine environment, which was convened in Dakar, Senegal, from 30 May to 1 June 2022. Ensuring legal certainty of key features of the new agreement, such as the circular economy and support for developing countries and countries with economies in transition, will be subject to particular scrutiny.
A Heap of Leaves or Fellow Travellers
Authors: Zhanaev Ayur 
Published: October 2022

Abstract
Much has been written about the role of ‘shamanism’ in the making of Mongol kinship. This article aims to explore the role of Buddhism in constructing kinship, which has received less scholarly attention. In particular, I investigate the ways the ‘anti-family’ orientation of Buddhism was propagated in Buryat society, which had assigned great social importance to kinship networks. In didactic texts compiled by Buryat lamas for the laity in the nineteenth and early twentieth centuries, lamas argued that, despite the impermanent character of kinship, kinship bonds nevertheless were to be arranged in a proper way to avoid multiplying sins. However, lamas did not offer a ready model or a special Buddhist ideal of the family organisation. Like in other regional contexts, Buddhist ethics were adapted to the existing cultural traditions and mostly emphasised proper roles and responsibilities in conjugal and parent-child relationships.
The Epic Legacy of Shono-Baatar
Authors: Ratcliffe Jonathan 
Published: October 2022

Abstract
Compared with epic heroes such as Geser and Jangar who are widely popular among the Mongolic peoples of Inner Asia, the far less well-known epic of Shono-Baatar stems from a determinable and relatively recent historical basis: the eighteenth-century Dzungar prince Louzang Shunu and his seeking sanctuary from persecution by his relatives in the Russian Empire. While legends and short songs about this figure are widely attested from Kalmykia to Xinjiang, only among the Buryats has any full-length oral epic been preserved: a single specimen taken down from storyteller Sagadar Shanarsheev in 1936. Although Shanarsheev’s epic possesses a complex political and textual history, it was almost wholly unknown beyond a few scholars until its republication in a dual-language Russian-Buryat edition in 2015. Since then, it has increasingly become an important part of the symbolism of Buryat cultural identity and has even been hailed as a world-class epic equal to the Iliad and Nibelungenlied.
Time-of-Day Effect on Postural Balance and Its Associations with Menopausal Symptoms in Postmenopausal Women
Authors: Lahiani Mariam , Ben Waer Fatma , Bouchaala Fatma , Laatar Rabeb , Rebai Haithem , Sahli Sonia 
Published: October 2022

Postmenopausal women suffer from postural balance issues. During a 24-hour time span, postural performance undergoes radical changes as influenced by the circadian rhythm. In this study, we aimed to investigate time-of-day effects on postural balance in postmenopausal women and balance relationships with menopausal symptoms. Two groups of women, aged 40–50 years, participated in this study: a menopausal group and a control group. We evaluated their postural balance and menopausal symptoms (mood, sleepiness and fatigue) in five sessions over the course of a day: at 06:00 hours, at 10:00, at 14:00, at 18:00 and at 22:00. The results showed that postural balance (center of pressure area (CoParea)) values of postmenopausal women were significantly worse ( p < .05) at 22:00. Moreover, at this time-of-day, participants in the menopausal group were more tired, less vigilant and experienced a lower mood. We found negative correlations between postural balance and both mood and fatigue levels. However, there was no time-of-day effect on postural balance, mood, fatigue, and sleepiness among participants in the control group. Thus, time-of-day should be considered a factor to control when assessing postural balance and designing intervention studies for postmenopausal women; and it is important for these women to be cautious of fall risks at night, as they are then less stable than at other times-of-day.
Cannabidiol in clinical and preclinical anxiety research. A systematic review into concentration–effect relations using the IB-de-risk tool
Authors: Kwee Caroline MB , van Gerven Joop MA , Bongaerts Fleur LP , Cath Danielle C , Jacobs Gabriël , Baas Johanna MP , Groenink Lucianne 
Published: October 2022

Background: Preclinical research suggests that cannabidiol (CBD) may have therapeutic potential in pathological anxiety. Dosing guidelines to inform future human studies are however lacking. Aim: We aimed to predict the therapeutic window for anxiety-reducing effects of CBD in humans based on preclinical models. Methods: We conducted two systematic searches in PubMed and Embase up to August 2021, into pharmacokinetic (PK) and pharmacodynamic (PD) data of systemic CBD exposure in humans and animals, which includes anxiety-reducing and potential side effects. Risk of bias was assessed with SYRCLE’s RoB tool and Cochrane RoB 2.0. A control group was an inclusion criterion in outcome studies. In human outcome studies, randomisation was required. We excluded studies that co-administered other substances. We used the IB-de-risk tool for a translational integration of outcomes. Results: We synthesised data from 87 studies. For most observations (70.3%), CBD had no effect on anxiety outcomes. There was no identifiable relation between anxiety outcomes and drug levels across species. In all species (humans, mice, rats), anxiety-reducing effects seemed to be clustered in certain concentration ranges, which differed between species. Discussion: A straightforward dosing recommendation was not possible, given variable concentration–effect relations across species, and no consistent linear effect of CBD on anxiety reduction. Currently, these results raise questions about the broad use as a drug for anxiety. Meta-analytic studies are needed to quantitatively investigate drug efficacy, including aspects of anxiety symptomatology. Acute and (sub)chronic dosing studies with integrated PK and PD outcomes are required for substantiated dose recommendations.
D2-like receptor activation by intranasal dopamine attenuates fear responses induced by electrical stimulation of the dorsal periaqueductal grey matter, but fails to reduce aversion to pit vipers and T-maze performance
Authors: de Figueiredo Rebeca Machado , Falconi-Sobrinho Luiz Luciano , Leite-Panissi Christie Ramos Andrade , Huston Joseph P , Mattern Claudia , de Carvalho Milene Cristina , Coimbra Norberto Cysne 
Published: October 2022

Background: Panic-like reactions elicited by electrical stimulation of the dorsal periaqueductal grey matter (ES-dPAG) seem to be regulated by dopamine (DA). We showed that DA applied intranasally (IN) increased escape-behaviour thresholds induced by ES-dPAG of rats, indicating a panicolytic-like effect. Aims: We investigated whether IN-DA increases escape-response thresholds induced by ES-dPAG by acting on D2-like receptors, and whether IN-DA affects escape responses elicited by the presence of a potential predator and by open space and height of the elevated T-maze (ETM) as well as motor performance in the open field (OF) test. Methods: Wistar rats exposed to ES-dPAG were treated with Sulpiride (SUL, 40 mg/kg, D2-like receptor antagonist) previously IN-DA (2 mg/kg). Independent groups of rats treated with IN-DA were submitted to prey versus snake paradigm (PSP), ETM and OF. Results: Anti-aversive effects of the IN-DA were reduced by SUL pretreatment in the ES-dPAG test. IN-DA did not affect the escape number in the PSP nor the escape latencies in the ETM as well as motor performance in the OF. Conclusions/interpretation: The IN-DA effects in reducing unconditioned fear responses elicited by ES-dPAG seem to be mediated by D2-like receptors. The lack of effects on panic-related responses in the ETM and PSP may be related to the possibility of avoiding the danger inherent to these models, a defence strategy not available during ES-dPAG. These findings cannot be attributed to motor performance. The decision-making responses to avoid dangerous situations can be orchestrated by supra-mesencephalic structures connected by non-dopaminergic inputs.
Microarray data reveal potential genes that regulate triple-negative breast cancer
Authors: Pan Chi , Cong Aihua , Ni Qingtao 
Published: October 2022

Objective Triple-negative breast cancer (TNBC) is characterized by a lack of targeted therapies and poor patient prognosis, and its underlying pathological mechanisms remain unclear. This study aimed to identify potential key genes and related pathways that are required for TNBC development. Methods We screened the Gene Expression Omnibus database for transcriptome data and identified differently expressed genes in TNBC. Then, we performed Gene Ontology analysis to determine the genes and pathways involved in TNBC development. We correlated significantly expressed genes and miRNAs using miRDB, TargetScan, miRWalk, and DIANA, and then validated the expression of CDK1 and miR-143-3p in TNBC patients. Results Eighteen genes were significantly upregulated in TNBC patients, and these were found to be enriched in cell metabolic process, cell division, mitochondrion, and respiratory chain. MiR-143-3p was found to be an upstream regulator of CDK1. Validation experiments revealed that CDK1 was upregulated while miR-143-3p was downregulated in clinical TNBC specimens. Conclusions Collectively, our results revealed 18 upregulated genes in TNBC. Notably, CDK1 and its related microRNA miR-143-3p could be potential therapeutic targets for TNBC.
Chemo-surgical approach in vulvar leiomyosarcoma: A case report
Authors: Capalbo Giuseppe , Logoteta Alessandra , Gallo Roberta , Cuccu Ilaria , Gentile Gabriella , Arienzo Francesca , Musella Angela , Pernazza Angelina , Perniola Giorgia , Di Donato Violante , Manganaro Lucia , Bogani Giorgio , Palaia Innocenza 
Published: October 2022

Introduction: Primary sarcoma of the vulva is an extremely rare entity, representing only 1%–3% of all vulvar malignant neoplasms. Among sarcomas, leiomyosarcoma (LMS) is the most prevalent histologic variant. Due to the rarity of LMS, guidelines are lacking and phase III trials have not been carried out, so clinical management is based on local clinical practice and physician experience. Case presentation: Here, we described a case of primary LMS of the vulva and its successful management, with the adoption of neoadjuvant chemotherapy and surgery. We report a case of a 74-year-old woman with 12.5 cm vulvar LMS. The patient received three cycles of neoadjuvant chemotherapy with a partial response. Radical vulvectomy with vulvar reconstruction with V-F flap was carried out. Surgical margins were negative. Three additional cycles of adjuvant chemotherapy were delivered. Results: One year after treatment, the patient was disease-free. Conclusion: There are no approved therapeutic protocols for this rare neoplasia. Surgery is the mainstay of treatment. However, it is not always feasible, so neoadjuvant chemotherapy was delivered for downstaging the vulvar lesion. We suppose that neoadjuvant chemotherapy has optimized the possibilities of radical surgery. Despite the anectodical nature of this case presentation, neoadjuvant chemotherapy seems a valid therapeutic option for managing patients with bulky vulvar sarcoma. Further large collaborative studies are warranted to identify the best therapeutic option for these patients.
Impact of Pharmacist Monitoring of Serum Triglycerides for Critically Ill Patients Receiving Propofol
Authors: Ivey Katelin A. , Bolesta Scott 
Published: October 2022

Background: Elevated serum triglycerides due to the use of propofol for sedation in the ICU is associated with adverse effects and serum triglyceride monitoring may be improved by pharmacists. Objective: To determine if there was improvement in serum triglyceride monitoring in ICU patients receiving propofol for sedation after implementation of a pharmacist-driven triglyceride monitoring protocol. Methods: This was a single-center pre-post-intervention retrospective cohort study. The protocol was implemented on January 10 2019. Data were collected over 1 year, and patients were divided between those started on propofol before and after protocol implementation. Results: There were 412 patients included in the final analysis with no significant differences between groups. There was a significant increase in the number of patients who had a triglyceride concentration obtained after protocol implementation (31.1% pre-vs 64.0% post-protocol; P < .001). For patients on propofol greater than 24 h, there was a significant increase in baseline triglyceride concentration obtained (7.6% pre-vs 15.1% post-protocol; P = .043). More instances of elevated triglyceride concentrations were identified by pharmacists than other providers (9 vs 5; P < .001). Time between propofol being ordered and first triglyceride concentration ordered was shorter (.86 days pre-protocol vs .71 days post-protocol; P = .064), but not statistically significant. Conclusion: Implementation of a pharmacist-driven protocol in the ICU increased the number of serum triglyceride levels obtained for patients receiving propofol for sedation. Pharmacists can improve triglyceride monitoring in patients receiving propofol and future studies should investigate the impact on outcomes.
The use of dupilumab in patients with HIV
Authors: Edmonds Nicole , Zhao Patricia , Flowers Richard H 
Published: October 2022

Background The goal of this study was to complete the first Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) based systematic review of dupilumab use in patients living with human immunodeficiency virus (HIV). Methods A systematic literature review was performed using PubMed, Google Scholar, Ovid MEDLINE, and Science Direct databases as well as an internal review using University of Virginia’s electronic medical record system. All reports of dupilumab use in patients with confirmed HIV were included. Results 14 published cases comprising 23 patients were identified and included in the review. Additionally, four unpublished cases from our own institution were included for a final cohort of 27 patients. A total of 25 patients (96%) were observed to have a clinical response, defined as improvement or complete resolution of their cutaneous or asthmatic symptoms. In 100% of patients, viral load improved or did not change, and in 80% of patients, CD4 counts remained stable. Side effects occurred in 48% of patients but were self-limited. Discussion and Conclusions All reported cases indicate that dupilumab is safe in patients with HIV with stable CD4 counts and low viral loads. Most patients had significant improvement within 2 months of treatment with mild side effects.
Physician–Medical Manufacturing Industry Relationships: Perceptions of Malaysians
Authors: Kaur A. , Singh S. , Ng D.C.Y. , Pok W.F. 
Published: October 2022

The relations between physicians and the medical manufacturing industry(MMI) which includes pharmaceutical, medical device or implants or life science industry, etc., are well known. To promote better physician–patient relationship and to safeguard patients’ interest, it has been proposed to make physician–industry financial relations transparent and accessible to public. This study aimed to explore Malaysian public’s perceptions towards these relationships. A survey questionnaire was specifically prepared to meet the objective of the study after a review of the existing literature. Statements describing various types of physician–industry financial interactions were formulated based on previous research. The participants were instructed to mark their response to each statement based on a 5-point Likert scale ranging from strongly disagree to strongly agree. More than half (57.1%) of the participants were aware of the relationships between physicians and MMI and online database was noted to be the most preferred type of disclosure. Age, gender, race, education status, annual income and subjective health influenced the perceptions. Since consumers (patients) are the key stakeholders of the healthcare industry, their opinions are important. It is hoped that disclosing the financial relationships will help them to make a better-informed decision while choosing their healthcare provider.