bluuebunny/crossref_metadata_2025_split huggingface dataset:
Memorable tourism experience: A review and research agenda
Authors: Hosany Sameer , Sthapit Erose , Björk Peter 
Published: April 2022

AbstractA decade of research has produced substantial results but the theorization of memorable tourism experience, often drawing on positive and environmental psychology, remains fuzzy and fragmented. Adopting state‐of‐the art practices, this study systematically reviews, synthesizes, and integrates the extant body of knowledge across multiple literature streams on memorable tourism experience. Our review indicates that research in this field has a geographical bias, largely neglects negative experiences, and mainly employs quantitative methods. We identify several gaps in the literature and propose the following seven recommendations for future research: (1) caution when using the memorable tourism experience scale; (2) the need for cross‐cultural studies; (3) positive and negative dimensions in conceptualizing memorable tourism experience; (4) overcoming the limitations of self‐report measures; (5) engaging in mixed methods research; (6) integrating suppliers' perspectives; and (7) combining theories, concepts, and disciplines. This study serves as a foundation for researchers and provides a holistic understanding of memorable tourism experience.
Detectors for gas‐phase photoacoustic spectroscopy: A review
Authors: Zhang Xueshi , Liu Lixian , Liu Yanyan , Zhang Le , Yin Xukun , Huan Huiting , Xi Teli , Shao Xiaopeng 
Published: April 2022

AbstractAcoustic detectors constitute a key factor of photoacoustic spectroscopy configuration, which is an ultrasensitive gas sensing method. This review aimed to discuss the recent development of acoustic detectors, including capacitive microphone, quartz tuning forks, and optical microphone. An overview of their applications for sensitive, selective, and quantitative trace gas detection was reported, and advantages and limitations of these detectors were presented.
Experimental demonstration of low complexity nonlinear compensation algorithm based on logistic regression
Authors: Wang Chuxuan , Tian Feng , Zhang Qi , Gao Ran , Wang Yongjun , Tian Qinghua , Wang Xishuo , Pan Xiaolong , Xin Xiangjun 
Published: April 2022

AbstractIn this paper, a novel algorithm based on logistic regression digital backpropagation (LR‐DBP) is proposed to mitigate the effect of dispersion and nonlinearity in a long‐distance optical transmission system. The LR‐DBP can evaluate nonlinear effects by estimating the cross‐entropy error and adjusting the structure of DBP. The experiment is setup to demonstrate an 80 Gbit/s 16QAM signal transmitted across 1000 km single‐mode fiber. The results show that LR‐DBP achieves a 1.8 dB launch power improvement over the dispersion compensation algorithm and a 0.6 dB launch power gain with DBP. The proposed algorithm could obtain with 19.2% computational complexity decrease and 19.6% central processing unit (CPU) running time decrease by calculating the average numbers of real multiplications and CPU running times.
Broadband circularly polarized monopole antenna with modified characteristics
Authors: Wang Lei , Yao Bin , Fang Wenxiao , Huang Chuangmian , Huang Yun , En Yunfei 
Published: April 2022

AbstractIn this letter, a novel wideband circularly polarized (CP) monopole antenna (CPMA) with modified characteristics is proposed. The CPMA comprises a rectangular ground with an L‐shaped strip, an inverted L‐shaped monopole, and an asymmetric U‐shaped strip as a parasitic element. Note that the proposed CPMA is fed by a coaxial probe instead of the traditional microstrip feed. The L‐shaped strip in the rectangular‐ground and parasitic asymmetric U‐shaped strip are used simultaneously to excite multiple CP resonant modes, which increase the CPMA's CP bandwidth. Both the simulated and measured results validate the proposed design. The proposed CPMA features a −10‐dB impedance bandwidth ranging from 2.06 to 4.05 GHz (65.1% centered at 3.055 GHz), and a wide 3‐dB axial ratio bandwidth ranging from 1.78 to 4.44 GHz (85.5% centered at 3.11 GHz), which has a potential application in the satellite digital audio radio service system.
Correlations between DWI, IVIM, and HIF‐1α expression based on MRI and pathology in a murine model of rhabdomyosarcoma
Authors: Yin Zhenzhen , Li Xiangwen , Zhang Yu , Tao Juan , Yang Yanyu , Fang Shaobo , Zhang Zhengyang , Yuan Yuan , Liu Yajie , Wang Shaowu 
Published: April 2022

PurposeTo investigate the correlation between DWI, intravoxel incoherent motion (IVIM), and hypoxia‐inducible factor 1‐alpha (HIF‐1α) expression in a nude mouse model of rhabdomyosarcoma based on imaging and pathological comparisons.MethodsHuman rhabdomyosarcoma‐derived (RD) cells were inoculated into the right thigh muscle of 20 BALB/c female nude mice. Mice were imaged using 3.0 Tesla MRI system. T1‐weighted imaging, T2‐weighted imaging, DWI, and IVIM images were obtained. ADW4.7 (GE Healthcare, ChicagoAQ34, IL, USA) was used for image processing of ADC, Dslow, Dfast, and f values. All parameter values were independently analyzed by 2 observers. Immunohistochemistry of HIF‐1α was performed. We used a specific image–pathology comparison method to ensure correct overlap between the image plane and the pathological section. Mann–Whitney U test or independent sample t test, Pearson or Spearman correlation test, the intragroup correlation coefficient, Kolmogorov–Smirnov test, and receiver operating characteristic curve were used. The correlation between DWI and intravoxel incoherent motion parameter values and HIF‐1α expression was determined.ResultsThere were 10 mice in the low‐expression group and 7 in the high‐expression group. The ADC and Dslow values were negatively correlated with HIF‐1α with correlation coefficients of −0.491 and − 0.702 (P = 0.045 and 0.002). The f value positively correlated with HIF‐1α expression (r = 0.485, P = 0.048). ADC, Dslow, and f were significantly different between the high‐HIF‐1α expression tumors and the low‐HIF‐1α expression tumors. ADC showed the best predictive performance among all parameters (area under the curve = 0.652, sensitivity = 83.3%, specificity = 63.6%).ConclusionThe parameter values of DWI and intravoxel incoherent motion can be used to evaluate the expression of HIF‐1α in rhabdomyosarcoma. ADC, Dslow, and f value showed correlation with the expression of HIF‐1α.
The effect of methocarbamol and mexiletine on murine muscle spindle function
Authors: Watkins Bridgette , Schuster Hedwig M. , Gerwin Laura , Schoser Benedikt , Kröger Stephan 
Published: April 2022

AbstractIntroduction/AimsThe muscle relaxant methocarbamol and the antimyotonic drug mexiletine are widely used for the treatment of muscle spasms, myotonia, and pain syndromes. To determine whether these drugs affect muscle spindle function, we studied their effect on the resting discharge and on stretch‐induced action potential frequencies of proprioceptive afferent neurons.MethodsSingle unit action potential frequencies of proprioceptive afferents from muscle spindles in the murine extensor digitorum longus muscle of adult C57BL/6J mice were recorded under resting conditions and during ramp‐and‐hold stretches. Maximal tetanic force of the same muscle after direct stimulation was determined. High‐resolution confocal microscopy analysis was performed to determine the distribution of Nav1.4 channels, a potential target for both drugs.ResultsMethocarbamol and mexiletine inhibited the muscle spindle resting discharge in a dose‐dependent manner with IC50 values around 300 μM and 6 μM, respectively. With increasing concentrations of both drugs, the response to stretch was also affected, with the static sensitivity first followed by the dynamic sensitivity. At high concentrations, both drugs completely blocked muscle spindle afferent output. Both drugs also reversibly reduced the specific force of the extensor digitorum longus muscle after tetanic stimulation. Finally, we present evidence for the presence and specific localization of the voltage‐gated sodium channel Nav1.4 in intrafusal fibers.DiscussionIn this study we demonstrate that both muscle relaxants affect muscle spindle function, suggesting impaired proprioception as a potential side effect of both drugs. Moreover, our results provide additional evidence of a peripheral activity of methocarbamol and mexiletine.
Analytical representation and efficient computation of the effective conductivity of two‐phase composite materials
Authors: Roy R. Valéry 
Published: April 2022

AbstractMany engineered materials display ordered or disordered microstructures. Such materials exhibit transport properties which are unmatched by their single‐phase homogeneous counterparts. These properties are obtained by the mixture of two or more phases typically characterized by a large contrast in their properties. For the development of these materials, it is critical to develop a robust computational framework in order to provide a fundamental understanding of how microstructure affects performance. This hinges on predicting their macroscopic properties, given the constitutive laws and spatial distribution of their constituents. To this end, this work presents a computational framework based on formulating periodic conduction transport problems in terms of boundary integral equations whose kernel is expressed in terms of Weierstrass zeta‐function. The components of the effective conductivity tensor are then sought in the form of power series expansions of a conductivity contrast parameter. To accelerate their convergence, these expansions are transformed into Padé approximants. Presently restricted to the case of two‐dimensional, two‐phase microstructures, this framework is shown to yield accurate results over the entire range of the contrast parameter. Representation of the kernel as a lattice sum allows the use the fast multipole method, thereby making computations significantly more efficient.
Surface modification of graphene oxide for preparing self‐healing nanocomposite hydrogels
Authors: Çeper Ezgi B. , Su Esra , Okay Oguz , Güney Orhan 
Published: April 2022

AbstractIn this work, graphene oxide (GO) and vinyl modified GO (V‐GO)‐based nanocomposite hydrogels with improved mechanical property and self‐healing ability have been synthesized and characterized. GO first was synthesized by modified Hummer's method using graphite powder and then functionalized with vinyl groups by using (3‐mercaptopropyl) trimethoxysilane (MPTS) via silanization method. The GO and V‐GO nanoparticles were characterized by FT‐IR, UV–vis spectroscopy, SEM, and dynamic light scattering technique (DLS). Hydrogels were obtained by in‐situ free‐radical polymerizations of acrylamide (AAm) and [3‐(methacryloylamino)propyl] trimethylammonium chloride (MAPTAC) monomers in the presence of GO and V‐GO nanoparticles. The effects of the amount of GO and V‐GO on the gelation profile and viscoelastic characteristics of the hydrogels were studied. The pH‐responsive action, swelling behavior, and swelling kinetics of the hydrogels with various GO and V‐GO contents were also evaluated. The mechanical performance of nanocomposite cationic hydrogels prepared with GO and V‐GO nanosheets was compared to the neat AAm‐MAPTAC hydrogels. The self‐healing ability of the hydrogels were elucidated as a function of the amount of GO and V‐GO nanosheets bound to the polymer network by physical interactions and chemical cross‐links, respectively.
Characterization methods for strain‐induced damage in polypropylene
Authors: Wiener Johannes , Preissegger Florian , Plank Bernhard , Arbeiter Florian , Kolednik Otmar , Pinter Gerald 
Published: April 2022

AbstractVarious methods are used to characterize the deterioration of mechanical properties in polymers. The focus is set on distinguishing between time‐dependent and irreversible damage in two different grades of polypropylene. First, digital image correlation is utilized to capture the stress–strain behavior during monotonic tensile tests. Changes in specimen volume are recorded throughout the experiment and serve as an indicator for crazes and voids. However, the elastic modulus, E, cannot be monitored throughout the entire experiment. Further analysis is performed in the form of cyclic load–unload tests. E and the residual strain, εres, as a function of the applied strain, εappl, are obtained for each cycle. Results show that E primarily suffers from the time‐dependent behavior of the tested polymers in this case. Subsequently, an alternative technique is applied, where specimens are prestrained and then allowed to relax. In the following dynamic mechanical analysis, viscoelastic effects can be avoided. Considerations on the onset and evolution of damage are made. Ultimately, these results are confirmed through microcomputed tomography, where the shapes and densities of defects are captured in high resolution.
Comparison between simulation and conventional training: Expanding the concept of social fidelity
Authors: Sardar Abdullah , Garaniya Vikram , Anantharaman Mohan , Abbassi Rouzbeh , Khan Faisal 
Published: April 2022

AbstractDaily operations onboard ships are very challenging due to man–machine interactions. To improve daily operational safety and to prevent losses due to machinery breakdown, effective risk management techniques need to be developed, considering various operational and environmental factors affecting the seafarers' performance. The current study explains the comparison between simulation and conventional classroom training to enhance safety in maritime operations in compromised environments. The contribution of this study lies in introducing the concept of social fidelity in simulator‐based training. This study bridges the gap between computer technology and collaborative learning activities in simulator‐based training. The result obtained through the simulation improves marine engineers' training and enhances the reliability of marine engines. This paper concludes by proposing a set of recommendations for the future design of simulator‐based training for marine engineers.
Eliciting judgements about dependent quantities of interest: The SHeffield ELicitation Framework extension and copula methods illustrated using an asthma case study
Authors: Holzhauer Björn , Hampson Lisa V. , Gosling John Paul , Bornkamp Björn , Kahn Joseph , Lange Markus R. , Luo Wen‐Lin , Brindicci Caterina , Lawrence David , Ballerstedt Steffen , O'Hagan Anthony 
Published: April 2022

AbstractPharmaceutical companies regularly need to make decisions about drug development programs based on the limited knowledge from early stage clinical trials. In this situation, eliciting the judgements of experts is an attractive approach for synthesising evidence on the unknown quantities of interest. When calculating the probability of success for a drug development program, multiple quantities of interest—such as the effect of a drug on different endpoints—should not be treated as unrelated. We discuss two approaches for establishing a multivariate distribution for several related quantities within the SHeffield ELicitation Framework (SHELF). The first approach elicits experts' judgements about a quantity of interest conditional on knowledge about another one. For the second approach, we first elicit marginal distributions for each quantity of interest. Then, for each pair of quantities, we elicit the concordance probability that both lie on the same side of their respective elicited medians. This allows us to specify a copula to obtain the joint distribution of the quantities of interest. We show how these approaches were used in an elicitation workshop that was performed to assess the probability of success of the registrational program of an asthma drug. The judgements of the experts, which were obtained prior to completion of the pivotal studies, were well aligned with the final trial results.
Pulmonary endothelial NEDD9 and the prothrombotic pathophenotype of acute respiratory distress syndrome due to SARS‐CoV‐2 infection
Authors: Alba George A. , Samokhin Andriy O. , Wang Rui‐Sheng , Wertheim Bradley M. , Haley Kathleen J. , Padera Robert F. , Vargas Sara O. , Rosas Ivan O. , Hariri Lida P. , Shih Angela , Thompson Boyd Taylor , Mitchell Richard N. , Maron Bradley A. 
Published: April 2022

AbstractThe pathobiology of in situ pulmonary thrombosis in acute respiratory distress syndrome (ARDS) due to severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection is incompletely characterized. In human pulmonary artery endothelial cells (HPAECs), hypoxia increases neural precursor cell expressed, developmentally downregulated 9 (NEDD9) and induces expression of a prothrombotic NEDD9 peptide (N9P) on the extracellular plasma membrane surface. We hypothesized that the SARS‐CoV‐2–ARDS pathophenotype involves increased pulmonary endothelial N9P. Paraffin‐embedded autopsy lung specimens were acquired from patients with SARS‐CoV‐2–​​​​​​ARDS (n = 13), ARDS from other causes (n = 10), and organ donor controls (n = 5). Immunofluorescence characterized the expression of N9P, fibrin, and transcription factor 12 (TCF12), a putative binding target of SARS‐CoV‐2 and known transcriptional regulator of NEDD9. We performed RNA‐sequencing on normal HPAECs treated with normoxia or hypoxia (0.2% O2) for 24 h. Immunoprecipitation‐liquid chromatography‐mass spectrometry (IP‐LC‐MS) profiled protein–protein interactions involving N9P relevant to thrombus stabilization. Hypoxia increased TCF12 messenger RNA significantly compared to normoxia in HPAECs in vitro (+1.19‐fold, p = 0.001; false discovery rate = 0.005), and pulmonary endothelial TCF12 expression was increased threefold in SARS‐CoV‐2–ARDS versus donor control lungs (p < 0.001). Compared to donor controls, pulmonary endothelial N9P‐fibrin colocalization was increased in situ in non‐SARS‐CoV‐2–ARDS and SARS‐CoV‐2–ARDS decedents (3.7 ± 1.2 vs. 10.3 ± 3.2 and 21.8 ± 4.0 arb. units, p < 0.001). However, total pulmonary endothelial N9P was increased significantly only in SARS‐CoV‐2–ARDS versus donor controls (15 ± 4.2 vs. 6.3 ± 0.9 arb. units, p < 0.001). In HPAEC plasma membrane isolates, IP‐LC‐MS identified a novel protein–protein interaction between NEDD9 and the β3‐subunit of the αvβ3‐integrin, which regulates fibrin anchoring to endothelial cells. In conclusion, lethal SARS‐CoV‐2–ARDS is associated with increased pulmonary endothelial N9P expression and N9P‐fibrin colocalization in situ. Further investigation is needed to determine the pathogenetic and potential therapeutic relevance of N9P to the thrombotic pathophenotype of SARS‐CoV‐2–ARDS.
Construction and Photoluminescence Properties of a Three‐Dimensional CdII Coordination Polymer Based on 2,5‐Di(4‐carboxy‐phenylthio) Terephthalic acid, 1,2‐Di(pyridin‐4‐yl)diazene
Authors: Zhou Shi‐Yi , Liu Wenlong , Tang Ru‐Ling 
Published: April 2022

AbstractIn recent years, metal‐organic frameworks composed of polydentate carboxylic acid esters and pyridyl ligands have attracted much attention because these ligands can adopt a variety of coordination modes to form crystalline products exhibiting interesting structures and various properties. A new cadmium(II) metal‐organic framework (MOF), poly[[half[μ5‐2,5‐di(4‐carboxy‐phenylthio) terephthalic acid‐κ5O1#3 : O2#3 : O3#2 : O4 : O4#2]][μ2‐1,2‐di(pyridin‐4‐yl)diazene‐κ2N1 : N4#1]cadmium(II)], namely [Cd(C22H10O8S2)0.5(C10H10N4)]n or [Cd(PSTP)0.5(4‐DiPyDz)]n, is constructed from CdII ions, 2,5‐di(4‐carboxy‐phenylthio) terephthalic acid (H4PSTP) and 1,2‐di(pyridin‐4‐yl)diazene (4‐DiPyDz) ligands under solvothermal conditions. The title compound was structurally characterized by single crystal X‐ray diffraction analysis, elemental analysis, powder X‐ray diffraction and IR spectroscopy. This structure indicates that in situ reduction of 4‐DiPyDz occurs during synthesis, containing a CdII center, a primary ligand H4PSTP and an ancillary ligand 4‐DiPyDz in one asymmetric unit. Thermal stability, solid state photoluminescence, and the ability to detect small organic molecules as fluorescent probes have also been investigated.
Green Synthesis of Novel Triazolothiadiazine‐Coumarins Catalyzed by Agro Waste Extract: An Approach towards In‐Silico and In‐Vitro Anti‐Fungal Activity
Authors: Hoolageri Swati R. , Nesaragi Aravind R. , Kamble Ravindra R. , Dixit Shruti , Vootla Shyamkumar , Joshi Shrinivas D. , Shaikh Sabakauser J. 
Published: April 2022

AbstractA green, commodious, immensely versatile synthetic route for agro waste extract WELPSA catalyzed cyclocondensation of biologically active triazolothiadiazine‐coumarin hybrid derivatives has been studied. A proficient synthesis offused heterocycles 9 i–wvia dehydrative condensation with cyclization of4‐((4‐amino‐5‐mercapto‐4H‐1,2,4‐triazol‐3‐yl)methyl)‐2‐aryl‐2,4‐dihydro‐3H‐1,2,4‐triazol‐3‐one (5 a‐‐c) and substituted bromoacyl coumarins (8 d‐‐h)has been incorporated in presence of different catalysts including WELPSA, a green catalyst. The in silico docking studies of these previously unknown compounds revealed favorable C score and Chemscore values and the in vitro antifungal assay against three fungal strains showed excellent to good activity.
Preparation of ZnCo2O4 Nanosheets Coated on evenly arranged and fully separated Nanowires with high capacitive and photocatalytic properties by a One‐Step Low‐Temperature Water bath method
Authors: Wang Jing , Wang Gang , Wang Shen , Hao Jian , Liu Baosheng 
Published: April 2022

AbstractIn this paper, ZnCo2O4 nanosheets coated on nanowires were fabricated by one‐step low‐temperature water bath thermal method. The length of the as‐prepared evenly arranged and fully separated nanowires were about 2–4 um. Through cyclic voltammetry, charge‐discharge, and other electrochemical testing methods, it is found that the structures have an excellent specific capacity and cyclic stability. At the current density of 3 A/g, the specific capacity of the structure reaches 1890 F/g and the cyclic stability of the material reaches 96.1 % after 10000 cycles at 5 A/g current density. Under the condition of the high current density of 5 A/g, the specific capacity of the ZnCo2O4//CNTs asymmetric devices is up to 180 F/g, and the cyclic stability for 10000 times is up to 97.14 %. In addition, the photocatalytic properties of the as‐prepared materials were also studied, and the results show that the degradation efficiency is very good. This work provides a new strategy for preparing ZnCo2O4 materials with excellent electrode materials for supercapacitor and photocatalyst.