bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE FEATURES AND THE MODEL OF ORGANIZATIONAL CHANGE FOR SMALL AND MEDIUM-SIZED BUSINESSES DURING PANDEMIC PERIOD
Authors: Божко Леся Михайловна 
Published: March 2022

Цель статьи состоит в определении особенностей организационных изменений, позволяющих пережить предприятиям малого и среднего бизнеса период пандемии COVID-19, и разработке модели проведения организационных изменений для таких условий. Малые и средние предприятия испытывают характерные для своего формата проблемы, усугубляемые введением ограничительных мер. В статье сформулированы особенности организационных изменений, реализуемых малым и средним предпринимательством для целей сохранения бизнеса. Проводимые изменения направлены не только на выживание, но и на формирование стратегических результатов, способных укрепить положение компании в будущем. Научная новизна заключается в разработке модели проведения организационных изменений в период пандемии с учетом специфики малого и среднего бизнеса и нестабильности окружения. Полученные результаты исследования могут использоваться субъектами малого и среднего предпринимательства разных сфер путем постановки конкретных целей, задач, подбора приемлемых для конкретного бизнеса решений в части проведения изменений.
The purpose of the article is to identify the features of organizational changes that allow small and medium-sized businesses to survive the period of the COVID-19 pandemic, and to develop a model for conducting organizational changes for such conditions. Small and medium-sized enterprises are experiencing format-specific problems exacerbated by restrictive measures. The article describes the peculiarities of organizational changes implemented by small and medium-sized enterprises for the purpose of preserving business. The ongoing changes are aimed not only at survival, but also at shaping strategic results that can strengthen the company's position in the future. The scientific innovation consists in developing a model for carrying out organizational changes during the pandemic period, taking into account the specifics of small and medium-sized businesses and the instability of the environment. The obtained research results can be used by small and medium-sized enterprises of different spheres by setting specific goals, tasks, and selecting solutions acceptable for a particular business in terms of making changes.
IMPACT OF INDUSTRY 4.0 ON CHANGES IN THE CONTENT OF LABOR FUNCTIONS
Authors: Ширинкина Елена Викторовна 
Published: March 2022

Актуальность исследования обусловлена тем, что текущий мировой рынок труда находится под воздействием IV промышленной революции (Индустрия 4.0). Цель исследования - оценить влияние циклических и внезапных трендов, воздействующих на рынок труда, и, как следствие, на формы организации труда и трудовые функции работников. В этой связи автором рассмотрены академические теории в контексте концептуализации влияния Индустрии 4.0 на рынок труда и трудовые функции, определены долгосрочные тренды трансформации рынка профессий. Научная новизна исследования заключается в обосновании концепции «Skills-biased technical change», смещенного в пользу высококвалифицированной рабочей силы, и теории вытеснения рутинного труда «Routine-biased technological change». Практическая значимость исследования заключается в обосновании выводов, учет которых позволит компаниям в условиях новых технологических вызовов соединить потребности бизнеса с фундаментальной подготовкой специалиста для его движения по новой карьерной траектории.
The relevance of the study is due to the fact that the current world labor market is under the influence of the IV industrial revolution (Industry 4.0). The purpose of the study is to assess the impact of cyclical and sudden trends affecting the labor market and, as a consequence, the forms of labor organization and labor functions of workers. In this regard, the author examines academic theories in the context of conceptualizing the impact of Industry 4.0 on the labor market and labor functions, identifies long-term trends in the transformation of the professions market. The scientific novelty of the research lies in the substantiation of the concept, biased in favor of a highly skilled labor force (skills-biased technical change, SBTC) and the theory of displacement of routine labor (routine-biased technological change, RBTC). The practical significance of the study lies in the fact that it will allow companies in the face of new technological challenges to combine business needs with the fundamental training of a specialist for his movement along a new career path.
HIGH-TECH COMPANY ROLE IN THE SYSTEM OF RUSSIAN SPATIAL DEVELOPMENT
Authors: Жуковский Андрей Дмитриевич 
Published: March 2022

Целью статьи является: на основе анализа зарубежного и отечественного опыта выявить основные положения, подтверждающие значимость размещения и функционирования высокотехнологичных компаний в регионах Российской Федерации; показать, что факторы роста региональной инфраструктуры - научно-технический прогресс и цифровизация, развитие человеческого капитала, инвестиции в развитие региона, концентрация высокотехнологичных компаний в регионе - способствуют эффективному развитию территорий, ускорению социально-экономического развития страны, а также повышению конкурентоспособности экономики в целом. Обоснован тезис, что размещение высокотехнологичных компаний в регионах будет эффективным инструментом повышения конкурентоспособности и инвестиционной привлекательности регионов для инвесторов при быстро меняющейся конъюнктуре мирового рынка в условиях перехода на возобновляемые источники энергии и снижающейся доли экспорта и потребления углеводородов в мире. С этой целью проанализирован национальный и зарубежный опыт процессов регулирования пространственного развития на макро (национальный и наднациональный), мезо (региональный, субнациональный) и микро (местный) уровнях для оценки различных моделей пространственного развития и факторов размещения высокотехнологичных компаний.
The purpose of the article is to identify the main provisions confirming the significance of the placement and functioning of high-tech companies in the regions of the Russian Federation; show that the growth factors of the regional infrastructure such as scientific and technological progress and digitalization, the development of human capital, investments in the development of the region, the concentration of high-tech companies in the region can contribute to the effective development of the territories, the acceleration of the socio-economic development of the country, as well as the increase of the competitiveness of the economy as a whole. The article justifies that placing high-tech companies in the regions is an effective tool for increasing the competitiveness and investment attractiveness of the regions for investors in the rapidly changing world market conditions in the context of the transition to renewable energy sources and the declining share of hydrocarbon exports and consumption in the world. The author analyses the national and foreign experience of spatial development regulation processes at macro (national and supranational), meso (regional, subnational) and micro (local) levels to assess various spatial development models and placement factors of high-tech companies.
Effect of autological red bone marrow aspirates on the microcirculation in the lower extremities of patients with diabetic angiopathy
Authors: Kamiandrouskaya A. A. , Fedzyanin S. D. , Kovalenko A. A. , Ratomski Yu. I. 
Published: March 2022

The lesion of the lower extremities vessels is one of the most dangerous complications of diabetes mellitus. The prognosis is bad in case of the development of critical ischemia.The aim of the study is to assess the effect of autological red bone marrow aspirates on the microcirculation in the soft tissues of the lower extremities of patients with diabetic angiopathy.The study included 36 patients with diabetic angiopathy of the lower limbs. The main group of 20 people consisted of the patients, whose treatment was added by revascularizing automyelotransplantation. The comparison group (16 people) included the patients who received standard complex conservative treatment.All patients underwent pulse oximetry on the 1st toe before the treatment start and within the control times. The painless walking distance was also assessed and the chronic arterial insufficiency stage was determined.In the main group, 18 patients retained their lower limbs, in the comparison group - 10 patients (pCox-Mantel = 0.015).There was an increase in the painless walking distance in 15 out of 18 patients in 3-6 months after treatment in the main group. There was no improvement in the comparison group. Chronic wounds healed in 4 out of 7 patients.The median SpO2 in the main group was 96 [92; 97] %, in the comparison group - 90 [88; 92] % (pMann_Whitney = 0.0035).The inclusion of revascularizing automyelotransplantation in the complex treatment of patients with diabetic angiopathy of the lower extremities contributes to the lower extremity preservation, as well as the relief of critical ischemia signs and the healing of chronic wounds.
The efficiency of remote ischemic postconditioning of the myocardium in rats with induced metabolic syndrome depends on the leptin level
Authors: Naryzhnaya N. V. , Logvinov S. V. , Kurbatov B. K. , Mukhomedzyanov A. V. , Sirotina M. A. , Chepelev S. N. , Vismont F. I. , Maslov L. N. 
Published: March 2022

Remote postconditioning (RPost) has a great therapeutic potential for protecting the myocardium during ischemiareperfusion in clinical practice. At the same time, an important problem limiting the use of conditioning effects in the clinic is the presence of metabolic disorders in the patient. The aim of this work was to assess the effect of induced metabolic syndrome (iMetS) on the efficacy of the infarct-limiting effect of remote ischemic postconditioning (RPost) in rats and to study the mechanisms of this effect.The study was carried out on Wistar rats. MetS was induced by high-carbohydrate high-fat diet. Criteria of metabolic syndrome were an increase in the weight of animals, abdominal fat volume, the development of arterial hypertension, hypercholesterolemia, an increase in triglycerides in serum, hyperleptinemia, hyperglycemia, the development of a state of insulin resistance by a significant increase in the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index and glucose tolerance. All animals were subjected to 45 min coronary occlusion and 120 min reperfusion.RPost led to a twofold reduction of infarct size in rats with intact metabolism (р< 0.0001), while in rats with iMetS a decrease in infarct size during RPost was 25 % (p= 0.00003), which was significantly lower than in animals without iMetC (р< 0.0001). A direct correlation was found between of infarct size during RPost and the serum leptin level of rats with iMetC.The presented data suggested that a decrease in the efficiency of remote postconditioning in rats with diet-induced metabolic syndrome depends on leptin content in blood.
Rationale importance of integrated determination of the level of CYFRA 21-1 and the receptors CXCR1, CXCR2, CD44v6 in the blood of patients with early-stage non-small cell lung cancer for predicting the tumor progression risk
Authors: Tahanovich A. D. , Kauhanka N. N. , Prohorova V. I. , Murashko D. I. , Kolb A. V. , Gotko O. V. , Matusevich V. A. 
Published: March 2022

Only 60-70 % patients with stage I and 35-40 % with stage II of non-small cell lung cancer (NSCLC) overcome the 5-year survival. The reason for such a high mortality rate is almost always a disease recurrence due to the presence of hidden metastases. This indicates a different course of the disease within one stage. There is a need to develop indicators that would allow predicting the tumor progression in patients at the early tumor development stages in order to correctly build the strategy and tactics of their treatment.The objective of the study is to find and substantiate the possibility of using the laboratory parameters characterizing the level of blood proteins involved in carcinogenesis when predicting the NSCLC progression in patients with early disease stages.In 1250 patients (839 men and 411 women) who were first diagnosed with NSCLC in the early stages (I and II), the duration of the recurrence-free period after treatment was analyzed according to the one-year observation results. In 103 patients (56 ± 22.5 years), the level of CYFRA 21-1, SCC, TPA, M2 of pyruvate kinase, chemokines CXCL5, CXCL8 and the concentration of HIF1a and hyaluronic acid in blood serum were determined by the enzyme immunoassay and that of the receptors CXCR1, CXCR2, CD44v6 in blood granulocytes, lymphocytes and monocytes - by flow cytometry. 62 persons had stage I (G1 - 20, G2 - 23, G3 - 19) and 41 - stage II (G1 - 14, G2 - 15 and G3 - 12).Based on the results of the one-year observation and the graphic analysis of Kaplan-Meier, the groups of low (stage I, G1-2 + stage II, G1) and high (stage I, G3 + stage II, G2-3) risk of tumor progression were identified. In high-risk patients, compared with low-risk patients, the level of CYFRA 21-1, the fluorescence intensity of the receptor CXCR1 in granulocytes, the relative content of the receptor CXCR2 in lymphocytes and the receptor CD44v6 in monocytes were higher (p< 0.05). With their participation, according to the results of logistic regression analysis, an equation was constructed, the calculation of which allows predicting the risk of tumor recurrence. The threshold for the equation is 0.467. The sensitivity of the forecasting model is 84.8 %, the specificity is 84.2 %, the predictive values of positive and negative results are 81.2 and 87.3 % respectively.The study results showed that a set of laboratory parameters, including blood CYFRA 21-1 level in combination with CXCR1, CXCR2, CD44v6 can be used in patients with early stages of NSCLC to assess the risk of tumor progression.
Laboratory Evaluation of Bigshot Maxim Against Three Species of Larval and Adult Mosquitoes, Aedes aegypti, Culex quinquefasciatus, and Anopheles quadrimaculatus
Authors: Bangonan Lea , Blore Kai , Peper Steven T. , Aryaprema Vindhya S. , Bond Jerry , Qualls Whitney A. , Xue Rui-De 
Published: March 2022

ABSTRACT
The use of synthetic insecticides has been the main approach in mosquito control programs (MCPs) to prevent or reduce mosquito populations. The global problem of insecticide resistance and the concern of environmental impacts of synthetic insecticides have resulted in the interest of botanicals as an alternative. In this study, the botanical product BigShot Maxim, which contains cedarwood oil (14%), thyme oil (0.53%), and cinnamon oil (0.23%) as active ingredients, was examined in adulticide and larvicide bioassays against Aedes aegypti, Culex quinquefasciatus, and Anopheles quadrimaculatus. In the adulticide bioassay, 100% mortality was reached at a dilution of 1:10 after 4 h of exposure for all 3 species. In the larvicide bioassay, at the highest tested concentration (30 ppm by volume) the greatest mortality was 96.44 ± 1.44% SE for Ae. aegypti, 92.44 ± 2.07% SE for Cx. quinquefasciatus, and 33.33 ± 3.61% for An. quadrimaculatus, respectively. Insecticidal properties presented in all the experiments indicate that BigShot Maxim could be a viable alternative to some synthetic insecticides used in MCPs.
Surveillance and Control of Culex quinquefasciatus Using Autocidal Gravid Ovitraps
Authors: Barrera Roberto , Acevedo Veronica , Amador Manuel 
Published: March 2022

ABSTRACT
We monitored trap captures of Culex quinquefasciatus using an interrupted time-series study to determine if autocidal gravid ovitraps (AGO traps) were useful to control the population of this mosquito species in a community in southern Puerto Rico. Data for this report came from a previous study in which we used mass trapping to control Aedes aegypti, resulting in a significant 79% reduction in numbers of this species. The AGO traps used to monitor and control Ae. aegypti also captured numerous Cx. quinquefasciatus. Culex quinquefasciatus was monitored in surveillance AGO traps from October 2011 to February 2013, followed by a mosquito control intervention from February 2013 to June 2014. Optimal captures of this mosquito occurred on the 2nd wk after the traps were set or serviced, which happened every 8 wk. Changes in collection numbers of Cx. quinquefasciatus were positively correlated with rainfall and showed oscillations every 8 wk, as revealed by sample autocorrelation analyses. Culex quinquefasciatus was attracted to and captured by AGO traps, so mass trapping caused a significant but moderate reduction of the local population (31.2%) in comparison with previous results for Ae. aegypti, possibly resulting from female mosquitoes flying in from outside of the study area and decreased attraction to the traps past the 2nd wk of trap servicing. Because Ae. aegypti and Cx. quinquefasciatus are frequently established in urban areas, mass trapping to control the former has some impact on Cx. quinquefasciatus. Control of the latter could be improved by locating and treating its aquatic habitats within and around the community.
Development and Validation of a Colorimetric Reverse Transcriptase Loop-Mediated Isothermal Amplification Assay for Detection of Eastern Equine Encephalitis Virus in Mosquitoes
Authors: Maddison Mikayla D. , Li Zhiru , Miley Kristi M. , Poole Catherine B. , Carlow Clotilde K. S. , Unnasch Thomas R. 
Published: March 2022

ABSTRACT
Eastern equine encephalitis virus (EEEV) is a highly pathogenic alphavirus that causes periodic outbreaks in the eastern USA. Mosquito abatement programs are faced with various challenges with surveillance and control of EEEV and other mosquito-borne illnesses. Environmental sampling of mosquito populations can be technically complex. Here we report the identification of biomarkers, development and validation of a colorimetric reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay for the detection of EEEV. Positive samples are easily visualized by a color change from pink to yellow. The assay was validated using EEEV from viral culture, experimentally spiked mosquito pools, and previously tested mosquito pools. The RT-LAMP assay detected viral titers down to approximately 10% of what would be present in a single infectious mosquito, based upon EEEV viral titers determined by previous competency studies. The RT-LAMP assay efficiently detected EEEV in combined aliquots from previously homogenized pools of mosquitoes, allowing up to 250 individual mosquitoes to be tested in a single reaction. No false positive results were obtained from RNA prepared from negative mosquito pools acquired from known and potential EEEV vectors. The colorimetric RT-LAMP assay is highly accurate, technically simple, and does not require sophisticated equipment, making it a cost-effective alternative to real time reverse transcriptase-polymerase chain reaction (RT-PCR) for vector surveillance.
PERLAKUAN AKUNTANSI PIUTANG DAN PIUTANG TAK TERTAGIH PADA CV. KANI GORO INDONESIA DI SURABAYA
Authors: Astrilarasati  , Wiratna Wiratna  
Published: March 2022

Penjualan kredit merupakan penjualan dengan cara mengirimkan barang sesuai dengan order yang diterima dari pembeli dan untuk jangka waktu tertentu perusahaan mempunyai tagihan kepada pembeli tersebut. Berbeda dengan penjualan tunai, uang langsung dibayar oleh pembeli pada waktu transaksi penjualan, maka penjualan kredit pembayarannya dapat diterima beberapa waktu kemudian sesuai dengan perjanjian yang dibuat oleh penjual dan pembeli. Catatan akuntansi yang digunakan dalam prosedur penjualan kredit adalah: jurnal penjualan, kartu piutang dan kartu persediaan. Dengan adanya penjualan kredit akan timbul adanya piutang dagang. Piutang merupakan imbalan atas barang dan jasa yang diberikan dalam bentuk uang dan merupakan hak perusahaan terhadap pihak – pihak yang berkewajiban terhadap perusahaan. Piutang sangat penting dan memiliki nilai yang signifikan terhadap aktiva lancar perusahaan karena didalam suatu perusahaan dagang maupan jasa. Pendekatan penelitian yang dilakukan dengan melakukan observasi melalui dokumen, catatan dan laporan keuangan perusahaan. Dengan ini menghasilkan pendekatan bersifat kualitatif. Ruang lingkup penelitian ini membahas perlakuan akuntansi piutang mulai dari pencatatan, pengakuan, pengukuran piutang dan juga pencatatan piutang tak tertagih. Obyek dari penelitian ini adalah CV. Kani Goro Indonesia Surabaya. Perusahaan ini bergerak dibidang perdagangan berbagai macam spare part sepeda dan mobil. Penulis mendapatkan temuan bahwa perusahaan masih menggunakan pencatatan piutang tak tertagih dengan metode langsung tanpa menyisihkan cadangan untuk piutang tak tertagihnya, sehingga pencatatan piutang pada neraca jumlahnya besar.
Dampak Pandemi Covid-19 Terhadap Perkembangan Ekonomi Dan Sosial Keagamaan Pada Masyarakat Pesisir
Authors: Sulistio Rahmat 
Published: March 2022

<p><em><strong>Abstract</strong><br /></em></p><p><em>This study examines the impact of the Covid-19 pandemic on the economic and socio-religious development of coastal communities in Pulau Simardan Village, Datuk Bandar Timur District, Tanjungbalai. The research method applied in this study is a descriptive survey method with qualitative data analysis. The data collection techniques used were observation, interviews, literature studies and documentation. This study aims to obtain information about the impact of the Covid-19 pandemic related to the economic and socio-religious developments that occur in coastal communities. The impact of the Covid-19 pandemic can be seen in the decline in people's income figures such as the decline in fish prices and reduced income for traders. On the other hand, socio-religious activities also have an impact by limiting every religious activity and keeping a distance in worship and trying to do all activities from home.</em></p>