bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of the PROGINS PgR polymorphism with susceptibility to female reproductive cancer: A meta-analysis of 30 studies
Authors: Zhou Chen , Zou Xiangman , Wen Xiaosha , Guo Zifen 
Published: July 2022

Aims
The progesterone response of the nuclear progesterone receptor plays an important role in the female reproductive system. Changes in the function of the progesterone receptor gene may increase the risk of reproductive cancer. The present study performed a meta-analysis to examine whether the progesterone receptor gene PROGINS polymorphism was a susceptibility factor for female reproductive cancer.

Materials and methods
We searched the PubMed, Cochrane Library, Web of Science and EMBASE databases for literature on PROGINS polymorphisms and female reproductive cancer published before September 2020. We evaluated the risk using odds ratios [ORs] and 95% confidence intervals via fixed effects models and random-effects models, which were calculated for all five genetic models. We grouped the analyses by race, cancer, and HWE.

Results
Thirty studies comprised of 25405 controls and 19253 female reproductive cancer cases were included in this meta-analysis. We observed that the Alu insertion polymorphism and the V660L polymorphism were significantly associated with female reproductive cancer in the allele and dominant genetic models. The allele genetic model and (Alu-insertion polymorphism: OR = 1.22, 95% CI = 1.02–1.45; V660L polymorphism: OR = 1.02, 95% CI = 1.00–1.13) dominant genetic model (Alu-insertion polymorphism: OR = 1.27, 95% CI = 1.03–1.58; V660L polymorphism: OR = 1.10, 95% CI = 1.011.19) demonstrated a significantly increased risk of female reproductive cancer. A subgroup analysis according to ethnicity found that the Alu insertion was associated with female reproductive cancer incidence in white (Allele model: OR = 1.21, 95% CI = 1.00–1.45; Heterozygous model: OR = 3.44, 95% CI = 1.30–9.09) and Asian (Dominant model: OR = 3.12, 95% CI = 1.25–7.79) populations, but the association disappeared for African and mixed racial groups. However, the V660L polymorphism was significantly associated with female reproductive cancer in the African (Allele model: OR = 2.52, 95% CI = 1.14–5.56; Heterozygous model: OR = 2.83, 95% CI = 1.26–6.35) and mixed racial groups (Dominant model: OR = 1.28, 95% CI = 1.01–1.62). Subgroup analysis by cancer showed that the PROGINS polymorphism increased the risk of cancer in the allele model, dominant mode and heterozygous model, but the confidence interval for this result spanned 1 and was not statistically significant. This sensitivity was verified in studies with HWE greater than 0.5.

Conclusion
Our meta-analysis showed that the progesterone receptor gene Alu insertion and the V660L polymorphism contained in the PROGINS polymorphism were susceptibility factors for female reproductive cancer.
Verification of examination procedures in clinical laboratory for imprecision, trueness and diagnostic accuracy according to ISO 15189:2012: a pragmatic approach
Authors: Antonelli Giorgia , Padoan Andrea , Aita Ada , Sciacovelli Laura , Plebani Mario 
Published: July 2022

Abstract

Background
The International Standard ISO 15189 is recognized as a valuable guide in ensuring high quality clinical laboratory services and promoting the harmonization of accreditation programmes in laboratory medicine. Examination procedures must be verified in order to guarantee that their performance characteristics are congruent with the intended scope of the test. The aim of the present study was to propose a practice model for implementing procedures employed for the verification of validated examination procedures already used for at least 2 years in our laboratory, in agreement with the ISO 15189 requirement at the Section 5.5.1.2.

Methods
In order to identify the operative procedure to be used, approved documents were identified, together with the definition of performance characteristics to be evaluated for the different methods; the examination procedures used in laboratory were analyzed and checked for performance specifications reported by manufacturers. Then, operative flow charts were identified to compare the laboratory performance characteristics with those declared by manufacturers.

Results
The choice of performance characteristics for verification was based on approved documents used as guidance, and the specific purpose tests undertaken, a consideration being made of: imprecision and trueness for quantitative methods; diagnostic accuracy for qualitative methods; imprecision together with diagnostic accuracy for semi-quantitative methods.

Conclusions
The described approach, balancing technological possibilities, risks and costs and assuring the compliance of the fundamental component of result accuracy, appears promising as an easily applicable and flexible procedure helping laboratories to comply with the ISO 15189 requirements.
Two-site evaluation of the Roche Elecsys Vitamin D total III assay
Authors: Favresse Julien , Schiettecatte Johan , Wolff Fleur , Cotton Frederic , Elsen Marc , Eucher Christine , Rosseels Catherine , Anckaert Ellen 
Published: July 2022

Abstract

Objectives
The high request for vitamin D testing in the last decades has led manufacturers to develop assays on automated immunoassay platforms. The objective of this study was to evaluate the performance of the new Elecsys Vitamin D total III assay for the measurement of total 25(OH)D.

Methods
A total of 844 serum samples collected in two clinical laboratories were used to evaluate the new Roche Elecsys Vitamin D total III assay. Comparisons with Roche Elecsys Vitamin D total II and liquid chromatography tandem mass spectrometry (LC-MS/MS) were carried out. Additionally, assay imprecision, linearity, matrix effects, biotin interference, cross-reactivity with 24,25(OH)2D3 and 3-epi-25(OH)D3, and outlier rate were evaluated for the Elecsys Vitamin D total III assay.

Results
Only the comparison between LC-MS/MS and Roche Elecsys Vitamin D total III achieved the optimal specification for bias (i.e., <3.4%). Imprecision, linearity and matrix effects showed acceptable results. The biotin interference threshold was increased up to 1,200 ng/mL and the outlier rate was low (0.26%). The cross-reactivity with 24,25(OH)2D3 and 3-epi-25(OH)D3 was weak or modest in available patient samples. However, using SRM972a with a high level of 3-epi-25(OH)D3 (enriched) revealed an important cross-reactivity with both Roche Elecsys Vitamin D total II and III assays (+74.7% and +73.7%).

Conclusions
In conclusion, the Roche Elecsys Vitamin D total III assay presents several advantages compared to the previous assay generation: higher biotin interference threshold, broader measuring range, and better comparability with LC-MS/MS. However, the cross-reactivity toward 3-epi-25(OH)D3 is still problematic in high titer samples.
On the use of binary operations for the construction of a multiply transitive class of block transformations
Authors: Cherednik Igor V. 
Published: July 2022

Abstract
We continue to study the set of block transformations

$ \{{\it\Sigma}^F : F\in\mathcal B^*({\it\Omega})\} $

implemented by a binary network Σ endowed with a binary operation F invertible in the second variable. For an arbitrary k⩾2 we obtain necessary and sufficient conditions for k-transitivity of the set of transformations

$ \{{\it{\it\Sigma}}^F \colon F\in\mathcal B^*({\it\Omega})\} $

, and propose an efficient method for checking whether these conditions hold. We also introduce two methods for construction of networks Σ such that the sets of transformations

$ \{{\it\Sigma}^F\colon F\in\mathcal B^*(\Omega)\} $

are k-transitive.
Trees with a given number of leaves and the maximal number of maximum independent sets
Authors: Taletskii Dmitriy S. , Malyshev Dmitriy S. 
Published: July 2022

Abstract
A complete description of trees with maximal possible number of maximum independent sets among all n-vertex trees with exactly l leaves is obtained. For all values of the parameters n and l the extremal tree is unique and is the result of merging the endpoints of l simple paths.
Properties of multitype subcritical branching processes in random environment
Authors: Vatutin Vladimir A. , Dyakonova Elena E. 
Published: July 2022

Abstract
We study properties of a p-type subcritical branching process in random environment initiated at moment zero by a vector z = (z
1, .., z

p
) of particles of different types. For p = 1 the class of processes we consider corresponds to the so-called strongly subcritical case. It is shown that the survival probability of this process up to moment n behaves as C(z)λ

n
for large n, where the parameters λ ∈ (0, 1) and C(z) ∈ (0, ∞) are explicitly described in terms of the characteristics of the process. We also demonstrate that the distribution of the number of particles of different types at moment n → ∞ (given its survival up to this moment) does not asymptotically depend on the number and types of particles initiated the process.
Ergodicity of the probabilistic converter, a serial connection of two automata
Authors: Kruglov Igor A. 
Published: July 2022

Abstract
The paper provides necessary and sufficient conditions for the the ergodicity of a serial connection of automata under which the output sequence of a substitution Mealy automaton is fed to the input of an output-free substitution automaton. It is shown that the condition of complete indecomposability of the state transition probability matrix of a Mealy automaton provides a sufficient condition for ergodicity of the probabilistic converter as a serial connection of automata. It is also shown that if the partial state transition functions of a Mealy automaton commute, then the condition of ergodicity of a serial connection is equivalent to that of both original probabilistic converters.
Continuality of classes of functions in multivalued logic with minimal logarithmic growth rate
Authors: Komkov Stepan A. 
Published: July 2022

Abstract
We show that in multivalued logic there exist a continual family of pairwise incomparable closed sets with minimal logarithmic growth rate and a continual chain of nested closed sets with minimal logarithmic growth rate. As a corollary we prove that any subset-preserving class in multivalued logic contains a continual chain of nested closed sets and a continual family of pairwise incomparable closed sets such that none of the sets is a subset of any other precomplete class.
Completeness criterion with respect to the enumeration closure operator in the three-valued logic
Authors: Marchenkov Sergey S. , Prostov Vasilii A. 
Published: July 2022

Abstract
The enumeration closure operator (the Π-operator) is considered on the set Pk
of functions of the k-valued logic. It is proved that, for any k ⩾ 2, any positively precomplete class in Pk
is also Π-precomplete. It is also established that there are no other Π-precomplete classes in the three-valued logic.
Finding periods of Zhegalkin polynomials
Authors: Selezneva Svetlana N. 
Published: July 2022

Abstract
A period of a Boolean function f(x
1, …, x

n
) is a binary n-tuple a = (a
1, …, a

n
) that satisfies the identity f(x
1 + a
1, …, xn
+ a

n
) = f(x
1, …, x

n
). A Boolean function is periodic if it admits a nonzero period. We propose an algorithm that takes the Zhegalkin polynomial of a Boolean function f(x
1, …, x

n
) as the input and finds a basis of the space of all periods of f(x
1, …, x

n
). The complexity of this algorithm is n

O(d), where d is the degree of the function f. As a corollary we show that a basis of the space of all periods of a Boolean function specified by the Zhegalkin polynomial of a bounded degree may be found with complexity which is polynomial in the number of variables.
Admissible and Bayes decisions with fuzzy-valued losses
Authors: Shvedov Alexey S. 
Published: July 2022

Abstract
Some results of classical statistical decision theory are generalized by means of the theory of fuzzy sets. The concepts of an admissible decision in the restricted sense, an admissible decision in the broad sense, a Bayes decision in the restricted sense, and a Bayes decision in the broad sense are introduced. It is proved that any Bayes decision in the broad sense with positive prior discrete density is admissible in the restricted sense. The class of Bayes decisions is shown to be complete under certain conditions on the loss function. Problems with a finite set of possible states are considered.
Development of a dimensionless and dynamic model of the three-phase trickle bed reactor in light naphtha isomerization process: effects of axial mass dispersion and liquid-solid mass transfer on isomers concentration
Authors: Ghafari Sara , Lay Ebrahim Nemati , Garshasbi Morteza 
Published: July 2022

Abstract
This study develops a general dimensionless model for a three-phase trickle bed reactor in the light naphtha isomerization process. The simulations are accomplished to study its conduct. The model brings up a one-dimensional axial dispersed flow to characterize dispersity and liquid-solid mass transfer in the forms of dimensionless Peclet and mass Stanton numbers under adiabatic conditions. It considers the essential reactions extant in the isomerization process comprising isomerization, hydrogenation, and hydrocracking reactions applying a precise approach of dimensionless kinetic equations and rate constants. The Crank–Nicolson method and a nonstandard finite difference approach are utilized for large systems of time-spatial PDEs to resolve the dynamic reactor model with MATLAB software. The aim is to elucidate how these large systems of PDEs and nonlinear ODEs can be solved with a comprehensive computation in the form of physical dimensionless numbers. The isomers compositions estimated with the suggested model are in corroboration simulation results obtained by empirical information. The dynamics are evaluated to consider the system conduct with a variation in the hydrogen concentration of the feedstock.
On the algebraic immunity of multiplexer Boolean functions
Authors: Mishra Prasanna R. , Pandey Shashi Kant 
Published: July 2022

Abstract
A multiplexer generator is a device that accepts two or more inputs and based on some logic sends one of them as output. In a special case when inputs to a multiplexer generator are

2

k

{2}^{k}

bits and one of them is selected according to the value of a

k

k

-bit number, a multiplexer generator can be regarded as a Boolean function in

2

k

+
k

{2}^{k}+k

variables. We call this generator a multiplexer Boolean function. Boolean functions serve as combiners and filters in cryptographic designs. The study of their cryptographic strength attracts the cryptographer because of the extremely simple and cost effective of their design. The study of algebraic attacks on multiplexer generators is another major concern to judging the suitability for its use in cryptographic designs. In this article, we calculate the algebraic immunity of the multiplexer Boolean function, which is not an obvious task in the case of a Boolean function like a multiplexer generator.
Atmospheric transport modelling related to radionuclide monitoring in support of the Comprehensive Nuclear-Test-Ban Treaty verification
Authors: Kalinowski M.B. 
Published: July 2022

Abstract
Global monitoring for relevant radionuclides in the atmosphere serves as part of the International Monitoring System to verify compliance with the Comprehensive Nuclear-Test-Ban-Treaty (CTBT). Atmospheric transport modelling can be applied to support these measurements and to get indications for possible source locations of detected relevant anthropogenic nuclides. This paper puts a focus on those issues that are of relevance to the International Data Centre (IDC). Possible methods of atmospheric transport modelling are outlined. The current tentative implementation at the IDC is described here.
»Verehrter Parteigenosse Landfried!«
Authors: Pahl Magnus , Wagner Armin 
Published: July 2022

Zusammenfassung
Vom Juli bis Dezember 2019 zeigte das Militärhistorische Museum der Bundeswehr (MHM) in Dresden eine Ausstellung anlässlich des 75. Jahrestages des Attentats auf Adolf Hitler und des geplanten Umsturzversuches vom 20. Juli 1944. Nach Publikation des Katalogs kamen Verdachtsmomente auf, einige der dort gezeigten Dokumente seien gefälscht. Prüfungen des Museums, unter anderem mit Unterstützung des Landeskriminalamtes Sachsen, bestätigten diesen Verdacht teilweise. Der Beitrag beschreibt, wie die entsprechenden Schriftstücke an das MHM kamen, warum sie für echt gehalten und in der Ausstellung präsentiert wurden und wie im Nachgang die Fälschung erkannt wurde. Er schließt mit knappen Überlegungen, was künftig daraus für den Erwerb von Museumsgut zu folgern ist.
Oscillatory and asymptotic behavior of solutions of third-order quasi-linear neutral difference equations
Authors: Gopal T. , Ayyappan G. , Graef John R. , Thandapani E. 
Published: July 2022

AbstractBy using comparison theorems, the authors investigate the oscillatory and asymptotic behavior of solutions to the third-order quasi-linear neutral difference equation$$\begin{array}{} \displaystyle \Delta\left(a(n)\left(\Delta^2 z(n) \right)^\alpha \right)+q(n)x^\beta(\sigma(n))=0, \end{array}$$wherez(n) =x(n) +px(n−k). Under less restrictive conditions on the coefficient functions and on the delay argumentσ(n) than currently found in the literature, their criteria improve a number of known related results. The results are illustrated with examples.
Fuzzy fixed point theorems and Ulam-Hyers stability of fuzzy set-valued maps
Authors: Alansari Monairah , Shagari Mohammed Shehu , Azam Akbar 
Published: July 2022

Abstract
In this paper, new common fuzzy fixed point theorems for sequence of fuzzy set-valued maps in the framework of complete b-metric spaces are established. Consequently, corresponding fixed point theorems in the setting of point-to-set-valued and single-valued mappings are deduced. A few nontrivial examples which dwell upon the generality of our results are provided. Moreover, following the fact that most available Ulam-Hyers type stability results deal with crisp mappings, we initiate the study of stability and well-posedness of functional inclusions involving fuzzy set-valued maps. It is well-known that solution of any functional inclusion is a subset of an appropriate ambient space. With this information, fuzzy fixed point problem for which the right-hand-side is a cut set of a fuzzy set-valued map is introduced. Furthermore, sufficient conditions for existence of solutions of Cantilever Beam Problem and integral inclusions are investigated to indicate the usability of our obtained results.
The crystal structure of dichlorido-bis((RS)-2-(4-chlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)hexanenitrile-κ1
N)zinc(II), C30H34Cl4N8Zn
Authors: Liu Hui-Jin 
Published: July 2022

Abstract
C30H34Cl4N8Zn, orthorhombic, Pca21 (no. 29), a = 20.235(2) Å, b = 6.5462(8) Å, c = 27.386(3) Å, V = 3627.6(7) Å3, Z = 4, R
gt(F) = 0.0477, wR
ref(F
2) = 0.1128, T = 293(2) K.
Evaluation of particle size on the physicochemical properties of Moringa oleifera Lam. stem powder
Authors: Zhang Yue , Liang Kehong , Wang Jing , Wang Aili , Pandiselvam R. , Zhu Hong 
Published: July 2022

Moringa oleifera Lam. stem (MOS) has been used for beneficial dietary and medicinal purposes. In this work, MOS samples of six different particle sizes were produced using sieve-based mechanical grinding to investigate the impact of varying particle sizes on the physicochemical properties of MOS powder. Scanning electron microscopic images revealed the destroyed fiber structures after grinding. The color turned greener and less yellow with decreasing particle size. The angle of repose significantly decreased from 70.36º to 60.25º, as the particle size declined, demonstrating the increasing fluidity of granules. The applied mechanical treatment did not alter the primary conformational properties of MOS except for destructing the intramolecular hydrogen bonds of cellulose and hemicellulose, thereby decreasing the crystallinity and thermal stability. Surface element analysis demonstrated more carbon-rich extractives on the particle surface as the particle size reduced. This study provided reasons behind improved dissolution and bioavailability of functional ingredients in plant-based granular materials by reducing particle size.
OSCILLATION OF A MATHEMATICAL PENDULUM TAKING INTO ACCOUNT GLOBE ROTATION
Authors: Shtanko Р. , Ryagin S. 
Published: July 2022

Purpose. Development of mathematical pendulum model which considers rotation of globe roundit’s own axis and parallel at which pendulum has been installed with use of Lagrange’s differential equations of the second kind. Checking whether oscillation plane position with respect to a meridian influences mathematical pendulum model.
Methods of research. Mathematical modelling, Lagrange’s differential equations of the second kind.
Results. Two design schemes of a mathematical pendulum have been developed which consider rotation of globe roundit’s own axis and pendulum installation place. They differ only by oscillation plane position with respect to a meridian. Formulas for kinetic energy for both schemes and the general formula for potential energy have been developed. The corresponding nonlinear differential equations are received by means of Lagrange’s differential equations of the second kind. The analysis of the received results show, that oscillation period of a mathematical pendulum depends not only on amplitude but as well on parallel at which the the test has been executed, and also oscillation plane position with respect to a meridian.
Scientific novelty. The model of a mathematical pendulum has been developed with use of Lagrange’s differential equations of the second kind, which considers rotation of globe roundit’s own axis and pendulum installation place.
Practical value.It’s found out, that not only amplitude, but position of oscillation plane with respect to a meridian, and also a parallel at which the the test has been executed influences mathematical pendulum oscillation. In particular, it has essential value when search of minerals is carried out by means of gravimetry using pendular devices, when smallest changes of a gravitational constant are estimated.