bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polygenic risk score as a determinant of risk of keratinocyte cancer in an Australian population‐based cohort
Authors: Liyanage U.E. , Law M.H. , Antonsson A. , Hughes M.C.B. , Gordon S. , van der Pols J.C. , Green A.C. 
Published: July 2022

AbstractBackgroundKeratinocyte cancer (KC) risk is determined by genetic and environmental factors. Genetic risk can be quantified by polygenic risk scores (PRS), which sum the combined effects of single nucleotide polymorphisms (SNPs).ObjectivesOur objective here was to evaluate the contribution of the summed genetic score to predict the KC risk in the phenotypically well‐characterized Nambour population.MethodsWe used PLINK v1.90 to calculate PRS for 432 cases, 566 controls, using 78 genome‐wide independent SNPs that are associated with KC risk. We assessed the association between PRS and KC using logistic regression, stratifying the cohort into three risk groups (high 20%, intermediate 60%, low 20%).ResultsThe fully adjusted model including traditional risk factors (phenotypic and sun exposure‐related), showed a significant 50% increase in odds of KC per standard deviation of PRS (odds ratio (OR) = 1.51; 95% confidence interval (CI) = 1.30–1.76, P = 5.75 × 10−8). Those in the top 20% PRS had over three times the risk of KC of those in the lowest 20% (OR = 3.45; 95% CI = 2.18–5.50, P = 1.5 × 10−7) and higher absolute risk of KC per 100 person‐years of 2.96 compared with 1.34. Area under the ROC curve increased from 0.72 to 0.74 on adding PRS to the fully adjusted model.ConclusionsThese results show that PRS can enhance the prediction of KC above traditional risk factors.
The first record of burrowing goby Trypauchen vagina (Bloch & Schneider, 1801) (Gobiiformes: Gobiidae: Amblyopinae) from the Atlantic Ocean
Authors: Trevisan João Pedro , Caires Rodrigo Antunes , Carvalho Vinícius Estrella Silva , Rotundo Matheus Marcos , dos Santos João Alberto Paschoa 
Published: July 2022

AbstractThe burrowing goby Trypauchen vagina has been reported from Brazil for the first time. This goby occurs naturally in the Indo‐Pacific region, where it is typically found burrowed in the bottom substrata of marine or brackish waters. Given its rapid development, extended longevity and multiple spawning cycles, the species is represented by large populations in Asian countries. The authors discuss the occurrence of this species in Brazilian waters and conclude that it was introduced via the ballast water of vessels arriving from Asia. They also compare this exotic taxon with the native Brazilian gobies, including Akko dionaea, Microdesmus and Gobioides, that have burrowing habits.
Brow gliding: A new non‐surgical concept for almond upturned eyes
Authors: Şahan Ali , Yeniay Yıldıray 
Published: July 2022

AbstractBackgroundThe eyes are one of the most prominent features of the face. To date, a vast majority of procedures have been described for periorbital rejuvenation. Among them, non‐surgical threading is an alternative and minimally invasive technique.ObjectiveWe developed a new non‐surgical threading technique to achieve long‐lasting almond‐shaped upturned eyes with brow lifting that we call “brow gliding”. We developed a new non‐surgical threading technique to achieve long‐lasting almond‐shaped upturned eyes with brow lifting that we call “brow gliding”. Here, we present details of our procedure and the clinical experience of our patients who have at least a 6‐month follow‐up period.Methods and MaterialsWe used polydioxanone cog threads in combination with knots to lift the lateral sides of the brows and eyes. By burying these knots in the subcutaneous tissue and extending the threads to the scalp fascia, we were able to spread the load of the threads over multiple stable structures in order to achieve an effective lifting impact.ResultsAccording to the subjective assessment scale, all patients described the improvements as very good or beyond expectations after the procedure. During the follow‐up period, 4 of 34 (11.8%) patients stated it was very good and 19 of 34 (55.9%) patients stated that it was still beyond expectations.ConclusionThe Brow Gliding technique is a promising office‐based cosmetic procedure for periorbital aesthetics with a prominent outcome and minimally invasive fashion.
Factors influencing nurses' intent to provide care involved in coronavirus disease 2019: Theory of planned behaviour perspectives
Authors: Hwang Areum , Kim Donghee 
Published: July 2022

AbstractAims and objectivesTo identify the factors influencing the intent to provide care among nurses involved in coronavirus disease 2019 (COVID‐19) care.BackgroundCOVID‐19 was first reported in Wuhan, China, in 2019. In 2020, the World Health Organisation declared it a pandemic, leading to 5,827,104 deaths and 421,203,495 confirmed cases as of 19 February 2022. The high transmissibility of COVID‐19 has prolonged the pandemic for over 2 years, resulting in deleterious effects on nurses' physical and mental health. The fear of infection and isolation may lead to negative experiences and perceptions among COVID‐19 frontline nurses, which may ultimately degrade the quality of patient care. Thus, it is essential to identify factors influencing of nurses' intent to provide care.DesignCross‐sectional study.MethodsData were collected from 169 nurses involved in direct COVID‐19 care at a hospital designated for infectious disease care in Korea from August to September 2021 using an online questionnaire. STROBE checklist was followed.ResultsNurses' intent to provide care significantly differed based on whether they lived with parents and had adequate availability of personal protection equipment. The correlation analysis indicated that the intent to provide care was significantly positively correlated with normative beliefs, control beliefs, attitude towards the behaviour, subjective norms and perceived behavioural control. Perceived behavioural control, control beliefs and attitude towards the behaviour were significant factors influencing nurses' intent to provide COVID‐19 care.ConclusionThis study showed that nurses perceived behavioural control and positive behaviour towards providing COVID‐19 care fundamentally influenced their intent to provide care.Relevance to clinical practiceIn clinical practice, the safety and rights of individual nurses who participated in COVID‐19‐related patient care are promoted, and ultimately, the quality of patient care is improved. Furthermore, active support at the organisation and government level is needed to strengthen the capabilities necessary for nursing patients with infectious diseases.
The effect of preoperative oral carbohydrate on the time to colostrum and amount of vaginal bleeding after elective cesarean section
Authors: Cheng Yan , Lu Yaojun , Liu Hailian , Yang Chen 
Published: July 2022

AbstractObjectiveTo investigate the effect of oral carbohydrate at 2 h before elective cesarean section on postoperative recovery indicators such as the time to colostrum and vaginal bleeding.MethodsWomen undergoing elective cesarean section under spinal‐epidural anesthesia, aged 20–40 years, with a body mass index (BMI) of 19–30 kg/m2 and an American Society of Anesthesiology (ASA) score of II were randomized to the oral carbohydrate group (the OC group), the oral placebo group (the OP group), or the control group (the C group). The OC group underwent oral carbohydrate preloading (300 mL/bottle), the OP group orally consumed 300 mL of distilled water, and the C group was forbidden from drinking or eating on the day of the operation. The time to colostrum, vaginal bleeding, time to exhaust, and complications were recorded.ResultsA total of 38 participants in the OC group, 37 in the OP group, and 37 in the C group completed the study. Compared with the OP group and the C group, the OC group produced colostrum significantly earlier, had a lower amount of 24‐h vaginal bleeding, and had a higher 24‐h consumption of analgesics. Compared with OP and OC groups, the C group took longer to exhaust. No significant intergroup difference was observed for any other indicator.ConclusionOral carbohydrates loading 2 h before elective cesarean section significantly reduces the time to produce colostrum and the amount of vaginal bleeding, which contributes to postoperative recovery.
Salivary gland polymorphous adenocarcinoma: Clinicopathological features and gene alterations in 36 Japanese patients
Authors: Fukumura Masahiro , Ishibashi Kenichiro , Nakaguro Masato , Nagao Toshitaka , Saida Kosuke , Urano Makoto , Tanigawa Maki , Hirai Hideaki , Yagyuu Takahiro , Kikuchi Kentaro , Yada Naomi , Sugita Yoshihiko , Miyabe Megumi , Hasegawa Shogo , Goto Mitsuo , Yamamoto Hidetaka , Ohuchi Tomoyuki , Kusafuka Kimihide , Ogawa Ikuko , Suzuki Hiroaki , Notohara Kenji , Shimoda Masayuki , Tada Yuichiro , Kirita Tadaaki , Takata Takashi , Morinaga Shojiroh , Maeda Hatsuhiko , Warnakulasuriya Saman , Miyabe Satoru , Nagao Toru 
Published: July 2022

AbstractBackgroundPolymorphous adenocarcinoma is a common intraoral minor salivary gland carcinoma in Western countries but is extremely rare in Japan. The current study aimed to characterize the clinicopathological features and status of molecular alterations of polymorphous adenocarcinoma‐associated genes, such as PRKD1/2/3, ARID1A, and DDX3X, in a large cohort of Japanese patients with polymorphous adenocarcinoma.MethodsWe examined the cases of 36 Japanese patients with salivary gland polymorphous adenocarcinoma and 26 cases involving histopathological mimics. To detect gene splits, fluorescence in situ hybridization was carried out for polymorphous adenocarcinoma‐associated genes. Additionally, we applied a SNaPshot multiplex assay to identify PRKD1 hotspot mutations.ResultsThis study revealed the indolent clinical course of polymorphous adenocarcinoma with a high 10‐year overall survival rate (92.9%), accompanied by occasional local recurrences and cervical lymph node metastasis (23.3%). Twenty cases (55.6%) of polymorphous adenocarcinoma (but none of the mimics) exhibited alterations in at least one polymorphous adenocarcinoma‐associated gene. Rearrangement of polymorphous adenocarcinoma‐associated genes and PRKD1 E710D were identified in 17 (47.2%) and 4 (11.1%) cases, respectively; one case showed coexisting PRKD3 split and PRKD1 E710D. In the multivariate analysis, high clinical stage (p = 0.0005), the presence of prominent nucleoli (p = 0.0003), and ARID1A split positivity (p = 0.004) were independent risk factors for disease‐free survival.ConclusionJapanese patients with polymorphous adenocarcinoma showed clinicopathological features similar to those reported in Western countries. This study disclosed that polymorphous adenocarcinoma‐associated genetic alterations were common and specific findings in polymorphous adenocarcinomas. The diagnostic role and possible prognostic significance of polymorphous adenocarcinoma‐associated genetic alterations in polymorphous adenocarcinomas were suggested.
Yeasts from Iranian traditional milk kefir samples: isolation, molecular identification and their potential probiotic properties
Authors: Rahmani B. , Alimadadi N. , Attaran B. , Nasr S. 
Published: July 2022

Abstract
Milk kefir is a fermented dairy product with numerous attributed health benefits due to the presence of a complex eukaryotic and prokaryotic microbiota. In this study, a total number of 26 yeast isolates were obtained from eight kefir samples from three different cities of Iran. The isolates belonged to Kluyveromyces marxianus, Saccharomyces cerevisiae, Pichia fermentans and P. kudriavzevii. The potential probiotic characteristics of the isolates were evaluated based on their ability to tolerate the stimulated condition of the gastrointestinal tract. In addition, hemolytic activity, adherence to different solvents, auto-aggregation, adhesion to the epithelial intestine-derived cells and antimicrobial activity of the selected isolates were evaluated. Overall, four yeast strains (three strains of S. cerevisiae and one strain of P. fermentans) showed resistance and survival ability against the gastrointestinal physiological conditions including acidic pH, presence of bile salt and digestive enzymes. They were able to grow at 37°C and had the capacity to adhere to epithelial intestine-derived cells. These results suggest that the selected strains can be proper candidates as probiotic yeast strains for the development of novel functional foods.
Population genomic structure in Goodman's mouse lemur reveals long‐standing separation of Madagascar's Central Highlands and eastern rainforests
Authors: Tiley George P. , van Elst Tobias , Teixeira Helena , Schüßler Dominik , Salmona Jordi , Blanco Marina B. , Ralison José M. , Randrianambinina Blanchard , Rasoloarison Rodin M. , Stahlke Amanda R. , Hohenlohe Paul A. , Chikhi Lounès , Louis Edward E. , Radespiel Ute , Yoder Anne D. 
Published: July 2022

AbstractMadagascar's Central Highlands are largely composed of grasslands, interspersed with patches of forest. The historical perspective was that Madagascar's grasslands had anthropogenic origins, but emerging evidence suggests that grasslands were a component of the pre‐human Central Highlands vegetation. Consequently, there is now vigorous debate regarding the extent to which these grasslands have expanded due to anthropogenic pressures. Here, we shed light on the temporal dynamics of Madagascar's vegetative composition by conducting a population genomic investigation of Goodman's mouse lemur (Microcebus lehilahytsara; Cheirogaleidae). These small‐bodied primates occur both in Madagascar's eastern rainforests and in the Central Highlands, making them a valuable indicator species. Population divergences among forest‐dwelling mammals will reflect changes to their habitat, including fragmentation, whereas patterns of post‐divergence gene flow can reveal formerly wooded migration corridors. To explore these patterns, we used RADseq data to infer population genetic structure, demographic models of post‐divergence gene flow, and population size change through time. The results offer evidence that open habitats are an ancient component of the Central Highlands, and that widespread forest fragmentation occurred naturally during a period of decreased precipitation near the last glacial maximum. Models of gene flow suggest that migration across the Central Highlands has been possible from the Pleistocene through the recent Holocene via riparian corridors. Though our findings support the hypothesis that Central Highland grasslands predate human arrival, we also find evidence for human‐mediated population declines. This highlights the extent to which species imminently threatened by human‐mediated deforestation may already be vulnerable from paleoclimatic conditions.
Evaluation on Academic Performance of Students in Teaching and Learning in Engineering Course
Authors: Md Nujid Masyitah , Tholibon Duratul Ain 
Published: July 2022

Teaching and learning session all over the world—refraining teachers and students from primary, secondary and tertiary education levels from attending physical classes in the traditional way has disrupted due to pandemic. The uncertainty situation in teaching and learning have brought concern in academic performance of the students to educators, students, institutional higher education as well as parents. However with emergency circumstance with proper planning and action in delivering their subject matter, impacts evaluation on academic performance to educators and students can be assessed. This study evaluates the course and program outcomes on academic performance of students for specific course at a department of university A in engineering course using open and distance learning approach. Case study method was used to evaluate the students’ academic performance by having quantitative data which were analyzed using descriptive statistics. The findings show the students are able to perform well in the course assessments despite the pandemic. The future trend in T&L will be flexible learning and open distance learning as well student-centered learning.
La narcoficción en el debate público de la prensa colombiana
Authors:   , Romero Chávez Lidice , Villadiego Prins Mirla 
Published: July 2022

El presente trabajo de investigación pretende indagar sobre cómo la prensa puede ser un factor para generar o no un debate analítico - constructivo en un tema tan álgido como lo es el narcotráfico, partiendo del escándalo mediático que se dio en los años 2009 y 2011 propiciado por la emisión de un formato televisivo denomino narcoficción (narco serie) en un país como Colombia en donde la construcción del Estado- Nación ha estado íntimamente relacionado con actos violentos causados, entre otros factores, por el narcotráfico hasta el punto de hacer trastabillar la gobernabilidad del Estado. La metodología empleada fue mixta al momento de abordar la pregunta de investigación la cual fue ¿De qué manera las notas periodísticas sobre de El Capo y Escobar: el Patrón del Mal contribuyen a generar un debate público sobre el impacto que ha tenido el narcotráfico en Colombia?. Teniendo como unidad de análisis: Las notas periodísticas de los periódicos "El Tiempo", "El Espectador" y "El Colombiano", en el periodo comprendido de agosto 2009 a marzo 2010 8 meses - (El Capo) y abril a diciembre del 2012 9 meses (Escobar: el Patrón del Mal) y como unidad de observación el debate público sobre el impacto del narcotráfico en la sociedad Colombiana. Por lo tanto, la técnica de recolección de datos contestaba parcialmente la pregunta de investigación debido a la necesidad de contrastar opiniones entre los diarios, se consideró necesario combinar los enfoques cuantitativos y cualitativos de investigación. Se obtuvo un corpus de investigación integrado por 179 notas periodísticas que incluían artículos de opinión, afiches, caricaturas, reportajes etc. Se puede concluir que pese a que la prensa es un medio de comunicación que tiene una gran oportunidad y capacidad para la reflexión, hoy en día se utiliza más como medio de publicidad más que de crítica. De igual forma la prensa está siendo utilizada como canal transmisor de ideas y no como un espacio para el análisis y reflexión de sucesos sociales que impactan a la comunidad.
Transformación comunitaria a partir de la lectura intercultural de Jn 20,1-18. El caso de cuatro comunidades de la Parroquia -La Resurrección-
Authors:   , Serna Gallego Francisco Antonio 
Published: July 2022

Este trabajo de grado denota las transformaciones en la identidad personal y comunitaria de grupos de lectores que se apropian de un texto bíblico específico, al igual que de las interpretaciones que otras comunidades hacen del mismo texto. Se utilizó como base de la investigación el material empírico generado en el proceso de Lectura Intercultural de la Biblia de Jn 20, 1-18 por cuatro comunidades de la parroquia "La Resurrección" de la ciudad de Bogotá - Colombia. El análisis se realizó en dos momentos del proceso: la lectura espontanea que cada comunidad hace del texto y la lectura de la interpretación realizada por un grupo par ubicado fuera de Colombia. La investigación estuvo orientada desde la perspectiva de la hermenéutica de la apropiación y la hermenéutica empírica. El manejo de los datos se hizo con base en la Teoría Fundamentada de Anselm Strauss y Barney Glaser con la ayuda del software para el análisis cualitativo de datos, Atlas Ti. El trabajo cuenta con cuatro capítulos: el primero da razón de los datos empíricos que se obtuvieron de los informes analizados sobre la identidad propia de las comunidades colombianas a partir de su carácter eclesial y laical, el segundo es la reflexión teológica suscitada por las datos del primer capítulo, el tercero tiene que ver con la visión de Dios que tienen las comunidades colombianas y su acción cotidiana en medio de ellas, el cuarto es la reflexión teológica a propósito de los datos del tercer capítulo.
Entre el límite y el enigma : la ontología de la finitud humana en Dilthey
Authors:   , Palacio Muñoz Manuel Darío 
Published: July 2022

El presente trabajo interpreta de la teoría diltheyana de la concepción del mundo como una ontología de la finitud de la existencia humana, para ello, se parte de la diferencia entre límite y finitud y, desde esta distinción, se establece una relación entre historia y vida. La historia como límite y la vida como finitud. Ello implica que no es posible una concepción del mundo más allá de los límites mismos de la historia, es decir, no hay nada fuera de la historia. Sin embargo, la vida, que constituye la base de toda concepción del mundo, se refiere constantemente a elementos atemporales y ahistóricos: la salvación, belleza, verdad, ideas y esencias. La vida vive vivencias contradictorias consigo misma. Aunque es una estructura de vivencias, éstas están limitadas históricamente y buscan trascender ese límite. La vida se constituye como enigma que no encuentra respuesta en sí mismo y por ende la busca fuera de la historia. El enigma sintetiza la finitud humana en una única vivencia: la muerte. Esta síntesis implica una comprensión de la temporalidad como historicidad distinta a una cronología lineal. Hay un fundamento ontológico más que positivo, así, la categoría base es la de "estructura" y no la de desarrollo. La muerte indica la constante finitud y el límite de la vida, que no se da como una vivencia más entre otras vivencias, sino que se constituye como elemento inherente de la vida humana. Es sobre la vivencia del enigma y no sobre las ciencias del espíritu que la teoría de la concepción del mundo adquiere un nuevo sentido y revitaliza la filosofía de Dilthey para la actualidad.
Relato e interacción : apuntes a una teoría de la narración en el mundo de la vida
Authors:   , Mora Forero Ernesto 
Published: July 2022

En tanto discurso imaginativo sobre la acción humana, la narración no responde únicamente a los intereses prácticos de la identidad personal y sus resultados más importantes: la construcción de la unidad narrativa de una vida y la autodesignación de un sujeto responsable, tal como sugiere la teoría narrativa de Paul Ricoeur. Bajo los mismos supuestos, la narración toma como propios otros intereses relacionados con la capacidad que tienen los sujetos particulares de descentrarse de su punto de vista particular para ingresar en el plexo de relaciones propias de toda comunidad humana. Desde esta óptica, una investigación sobre la narración puede tomar como suyos de manera singular los conceptos de "acción social", en tanto forma del actuar humano orientada específicamente hacia otros, y el mundo de la vida como fondo común de saber donde los actos humanos adquieren significación y legitimidad.
Naturaleza y libertad en Schelling
Authors:   , Camacho Galindo Jorge Erwin 
Published: July 2022

Naturaleza y libertad no son conceptos aislados, su común denominador es la identidad. Se expone esta doble condición de la identidad en Schelling. La filosofía se inaugura con la pregunta sobre la naturaleza. En su escrito de 1797, se evidencia la naturaleza como identidad o la identidad de la serie real con la ideal, entre producto y productividad, el vínculo entre la filosofía de la naturaleza y la filosofía de la identidad. Tal reunión es originaria de la naturaleza del individuo, las cosas externas no son reales en sí mismas. La identidad como absoluto es reconocida por la diferencia, la identidad de la naturaleza es indiferencia. En 1809, la libertad es identidad, mostrando aquí la transformación de la identidad. El absoluto es el único primero del cual se derivan los otros conocimientos. El mundo absoluto completo se reduce a la unidad absoluta de Dios en que reside el fundamento de las ideas y lo finito se fundamenta en un alejamiento. Así, la realidad propia y verdadera de lo primero intuido es la libertad como repetida posibilidad de la caída. La personalidad del hombre consigue su libertad al separarse de Dios, hacerse espíritu y elevarse por encima de los principios propios del creador y sus criaturas, con lo cual se libera de la naturaleza y es principio eterno, el mal se basa en una "inversión de los principios". El hombre también puede elegir libremente abandonarse en los brazos del creador. Esta es la libertad en su identidad simple.