bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS SUPPORT VECTOR REGRESSION DENGAN ALGORITMA GRID SEARCH UNTUK MEMPREDIKSI HARGA SAHAM
Authors: Hermawan Andri , Mangku I Wayan , Ardana N. K. Kutha , Sumarno Hadi 
Published: August 2022

Pada artikel ini dikaji suatu metode yang dapat digunakan untuk meramalkan harga saham. Tujuan dari penelitian ini adalah memperkenalkan metode Support Vector Regression dengan Algoritma Grid Search untuk memprediksi harga saham INDF dan MYOR serta melakukan peramalan satu periode ke depan pada kedua perusahaan tersebut. Hasil kajian menghasilkan model prediksi terbaik untuk data saham INDF dengan nilai MAPE dan pada data testing berturut-turut sebesar 5.570% dan 79.9%, sedangkan untuk data saham MYOR diperoleh nilai MAPE dan pada data testing berturut-turut sebesar 2.954% dan 96%. Hasil penelitian juga menunjukkan prediksi harga saham INDF dan MYOR untuk satu periode selanjutnya (31 Desember 2021) berturut-turut sebesar Rp 6326.88/lembar dan Rp 2039.31/lembar.
संस्कृति निर्माणया आधार
Authors: वज्राचार्य Bajracharya वज्रमुनि Bajramuni 
Published: August 2022

जंगली अवस्थां सभ्य जुयाः म्वाय्‌स:गु अवस्थाधुंकाः मनूतय्‌सं थःगु बुद्धि विवेक छेलाः चिन्तन याय्‌गु झोलय्‌ संस्कृतिया निर्माण जुल । मनूतय्‌गु मजीमगाःगु आवश्यकता पूवंकेगु धैगु सभ्यता खःसा सभ्य जुयाः गुकथं म्वाय्‌गु धैगु चिन्तनया उपज संस्कृति खः । लं पुनेगु, बाजं थाय्‌गु सभ्यताया चिं खःसा लं पुनेगु बाजं थाय्‌गु कलात्मक चिन्तन संस्कृति खः । थुजोःगु चिन्तनय्‌ उगु थाय्‌या लकस, मौसम, प्राकृतिक वस्तु, भूगोलं तःधंगु भूमिका म्हिती । पर्यावरणपाखें मनूतय्‌सं थःगु शारीरिक अस्तित्व लेंकातय्‌गु कुतः यानाचोनी । थः व थः चोनागु समाजया अस्तित्व लेंकेगु, निरन्तरता बीगु लागि याःगु मंकाः कुतःपाखें संस्कृतिया जन्म जुइ । संस्कृत भाषाय्‌ परिष्कृतया अर्थय्‌ छेलातःगु खनेदु । थुगु चोसुइ नेपाःगाःया नेवाःतय्‌सं न्ह्याकाचोंगु संस्कृतियात लिधँसा दय्‌कागु दु । भौगोलिक, धार्मिक आस्थाकथं नेवाः संस्कृति निर्माण जुयाचोंगु खनेदु । नेवाः संस्कृति निर्माणया आधार हिन्दू बौद्ध दर्शन चिन्तनपाखें प्रभावित खनेदुसा थुगु चिन्तनया मूल आधार पर्यावरण हे खनेदु । जुलियन स्टेवार्डया सांस्कृतिक पर्यावरणया सिद्धान्तयात थुगु चोसुइ छेलेगु जुइ । जुलियन स्टेवार्डया धारणाकथं पर्यावरणपाखें मनूया जीवनय्‌ प्रत्यक्ष असर लाकी । उगु थाय्‌या लकसया अन्तरक्रियापाखें हे विशिष्ट संस्कृतिया विकास जुइ । प्रकृतिनाप संघर्ष याय्‌बले सुनां त्याकेफै वयागु अस्तित्व लेनाचोनी । सु संघर्षय्‌ बुइ व लोप जुइ डार्बिनया विकासवादी सिद्धान्तया आधारय्‌ जुलियन स्टेवार्डं संस्कृतिया निर्माण पर्यावरणया आधारं जुइ धैगु सांस्कृतिक पर्यावरणया सिद्धान्तयात परिक्षण याय्‌कथं थुगु चोसु तयार जूगु दु ।
Combinational Logic Analysis with Laser Voltage Probing
Authors: Ravikumar Venkat Krishnan , Lua Winson , Ranganathan Gopinath , Phoa Angeline 
Published: August 2022

Abstract
This article explains how laser voltage probing (LVP) can be used to analyze combinational logic circuits. The authors describe how the technique is aided by the development and use of a waveform library and a corresponding truth table. They also present a case study in which the new technique is used to isolate faults in a combinational logic circuit consisting of multiple gates.
Applied Failure Analysis Tools and Techniques Toward Integrated Circuit Trust and Assurance
Authors: Kimura Adam G. , Waite Adam R. , Scholl Jonathan , Via Glen D. 
Published: August 2022

Abstract
Traditional post-fabrication testing can reliably verify whether or not an IC is working correctly, but it cannot tell the difference between an authentic and counterfeit chip or recognize design changes made with malicious intent. This article presents an IC decomposition workflow, based on FA tools and techniques, that provides a quantifiable level of assurance for components in a zero trust environment.
The mobile edge computing task offloading in wireless networks based on improved genetic algorithm
Authors: Shang Zhanlei , Zhao Chenxu 
Published: August 2022

In order to overcome the problems of high unloading time cost, long unloading task delay and poor load balance of traditional offloading methods, this paper studies the mobile edge computing task offloading method of wireless network based on improved genetic algorithm. Based on the wireless network mobile edge computing architecture, a wireless network mobile edge computing task scheduling scheme is constructed to lay the foundation for subsequent task offloading. Then, the improved genetic algorithm is used for initial operation allocation and offloading priority ranking, and the mobile edge computing task offloading is realized by dynamically adjusting the trade-off coefficient. The experimental results show that the offloading time cost of this method is between 0.16 min–0.31 min, the offloading task delay is between 1.05 s–1.47 s, and the load balance can reach 97.9%, indicating that it effectively realizes the design expectation.
RESTRICTION ON THE RIGHTS OF PARTICIPANTS IN PRE-TRIAL PROCEEDINGS IN CRIMINAL PROCEDURE
Authors: Качалов Егор Викторович 
Published: August 2022

The purpose of the article is to study the legal essence of restricting the rights of participants in pre-trial proceedings in criminal procedure, the specific goals of their restriction, the list of rights that may be subject to restriction, grounds, criteria, conditions, as well as limits of restriction. The article uses methods of system analysis, synthesis and generalization. Results: the author concludes that the system of restricting the rights of participants in pre-trial proceedings in criminal cases includes: objectives, grounds, conditions, criteria and limits of restriction; the powers of officials provided for by the criminal procedure law to restrict the rights of participants in proceedings; procedural rights of participants in criminal proceedings, the exercise of which is aimed at ensuring that coercive measures are not applied to them; procedure and terms for restricting the rights of participants in pre-trial proceedings, which vary depending on which right is subject to restriction; control over the restriction on the rights of participants in pre-trial proceedings (procedural control, prosecutorial supervision, judicial control). The specific purpose of restricting rights in pre-trial proceedings is to ensure the proper conduct of criminal proceedings. The limits of restriction on the rights of participants in pre-trial proceedings are determined by the specific purpose of legal restriction, the nature and specificity of the investigative or procedural action, in the exercise of which the rights are restricted by the discretion of the official, who decides on the specific restriction, which is formed on the assessment of the actual situation, the characteristics of the person whose rights are subject to restriction. Any restrictions on rights are exercised only on the basis of a procedural decision by an official (inquirer, investigator, court) in accordance with the law and if there are grounds for it. The most significant restrictions on the rights of participants in criminal proceedings are permitted only by a judicial decision.
THERMODYNAMICALLY STABLE PHASES OF THE Ag9GaSe6 – Ag8GeSe6 SYSTEM AT T<600 K AND THEIR PHYSICO-CHEMICAL PROPERTIES
Authors: Moroz Mykola , Demchenko Pavlo , Prohorenko Myroslava , Soliak Ludmila , Prohorenko Serhii , Reshetnyak Oleksandr 
Published: August 2022

The synthesis of thermodynamically stable phases of the Ag9GaSe6–Ag8GeSe6 (І) system at T<600 K were performed in the electrochemi­cal cells (ECCs): (−) С | Ag | SЕ | R(Ag+) | PЕ | С (+), where C is graphite, Ag is the left (negative) electrode, SE is the purely Ag+ ion conducting solid electrolyte (Ag2GeS3-glass), PE is the right (positive) electrode, and R(Ag+) is the region of PE that contact with SE. PEs of ECCs were prepared from finely ground non-equilibrium mixtures of the compounds (Ag9GaSe6)1–х and (Ag8GeSe6)х, х=0.05, 0.1, 0.2, … , 0.9. Shifted from the left electrode to the R(Ag+) region for thermodynamic reasons Ag+ ions acted as the nucleation centers for the equilibrium phases of the x compositions, that is as the catalysts for reconstruction of the metastable mixtures of ternary compounds.
The reproducibility of the EMF vs T dependences in the heating-cooling cycles is a result of the completion of reconstruction in the R(Ag+) region. Experimental dependences EMF vs T of ECCs with PE of mixtures of compounds indicated x, ECCs with PE of the Ag9GaSe6 and Ag8GeSe6 compounds are charac­terized by several discrete linear regions with different temperature intervals and functional dependences on temperature. The equations of the temperature dependences of the partial Gibbs energies of Ag-component in alloys for each discrete section of the specific x=0, 0.3, 0.5, 0.7, 1.0 were established for the first time and values of the standard partial functions were calculated. The bypass lines drawn through the points of EMF values of the cells at T=const for arbitrarily selected temperatures 298 K, 341 K, 395 K, 445 K, and 495 K in the range 280-500 K determine the phase composition of the equilibrium T-x space of (I) as: a solid solution based on compound Ag17GaGeSe12 in the range of 0.25≤x≤0.75, solid solutions based on the compounds (Ag9GaSe6)1–х for 0≤х≤0.15 and (Ag8GeSe6)х for 0.83≤х≤1, and two two-phase sections in the ranges 0.15≤x≤0.25 and 0.73≤x≤0.77. Some parameters of the crystal structure, the values of the total and ionic components of conductivity, the transfer numbers in the range of 290–380 K, and the integral va­lues of the standard thermodynamic functions of the Ag17GaGeSe12 compound were established for the first time.
Quaking but not parkin is the major tumor suppressor in 6q deleted region in glioblastoma
Authors: Aksoy Yasar Fatma Betul , Shingu Takashi , Zamler Daniel B. , Zaman Mohammad Fayyad , Chien Derek Lin , Zhang Qiang , Ren Jiangong , Hu Jian 
Published: August 2022

Glioblastoma (GBM) is a high-grade, aggressive brain tumor with dismal median survival time of 15 months. Chromosome 6q (Ch6q) is a hotspot of genomic alterations, which is commonly deleted or hyper-methylated in GBM. Two neighboring genes in this region, QKI and PRKN have been appointed as tumor suppressors in GBM. While a genetically modified mouse model (GEMM) of GBM has been successfully generated with Qk deletion in the central nervous system (CNS), in vivo genetic evidence supporting the tumor suppressor function of Prkn has not been established. In the present study, we generated a mouse model with Prkn-null allele and conditional Trp53 and Pten deletions in the neural stem cells (NSCs) and compared the tumorigenicity of this model to our previous GBM model with Qk deletion within the same system. We find that Qk but not Prkn is the potent tumor suppressor in the frequently altered Ch6q region in GBM.
Efficacy and safety of hybutimibe in combination with atorvastatin for treatment of hypercholesteremia among patients with atherosclerotic cardiovascular disease risk equivalent: A multicenter, randomized, double-blinded phase III study
Authors: Qi Litong , Chen Jiyan , Li Xiaodong , Qi Xiaoyong , Ding Chunhua , Chen Xiaoping , Gu Xiang , Xiao Wenliang , Zhao Shuiping , Dong Yugang , Zheng Mingqi , Huang Kai , Tang Liangqiu , Guo Xiaomei , Wang Fang , Fu Guosheng , Li Junxia , Huo Yong 
Published: August 2022

BackgroundTo evaluate the safety and efficacy of hybutimibe plus atorvastatin for lipid control in hypercholesterolemia patients with atherosclerotic cardiovascular disease risk equivalent.MethodsIn this double-blind phase III study, we 1:1 randomly assigned 255 hypercholesterolemia patients with atherosclerotic cardiovascular disease to receive hybutimibe plus atorvastatin or placebo plus atorvastatin. The primary endpoint was the rate of change of plasma low-density lipoprotein-cholesterol (LDL-C) level at 12 weeks from baseline. The secondary endpoints were plasma total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), non-HDL-C, apoprotein (Apo) B, and 2-, 4-, 8-, and 12-week Apo A1 levels change rate and rates of change of plasma LDL-C levels at 2, 4, and 8 weeks from baseline.ResultsFrom April 2016 to January 2018, 128 in the hybutimibe plus atorvastatin group and 125 in the atorvastatin group were included in modified intention-to-treat (mITT) analysis. After 12 weeks of treatment, LDL-C level changed from 2.61 mmol/L (±0.30) at baseline to 2.18 mmol/L (±0.45) in the hybutimibe plus atorvastatin group and from 2.58 (±0.31) mmol/L to 2.40 (± 0.46) mmol/L in the atorvastatin group (P &lt; 0.0001), in mITT. The change rate in the hybutimibe plus atorvastatin group was significantly higher than that in the atorvastatin group (P &lt; 0.0001); the estimated mean rates of change were −16.39 (95% confidence interval: −19.04, −13.74) and −6.75 (−9.48, −4.02), respectively. Consistently, in per-protocol set (PPS) analysis, the rate of change of LDL-C in the hybutimibe plus atorvastatin group was significantly higher than that in atorvastatin group. Significant decreases in the change rates of non-HDL-C, TC, and Apo B at 2, 4, 8, and 12 weeks (all P &lt; 0.05) were observed for hybutimibe plus atorvastatin, while the differences were not significant for HDL-C, TG, and Apo-A1 (all P &gt; 0.05). During the study period, no additional side effects were reported.ConclusionsHybutimibe combined with atorvastatin resulted in significant improvements in LDL-C, non-HDL-C, TC, and Apo B compared with atorvastatin alone. The safety and tolerability were also acceptable, although additional benefits of hybutimibe plus atorvastatin were not observed compared with atorvastatin alone in HDL-C, TG, and Apo-A1.
Left ventricular ejection fraction and cardiac biomarkers for dynamic prediction of cardiotoxicity in early breast cancer
Authors: Posch Florian , Niedrist Tobias , Glantschnig Theresa , Firla Saskia , Moik Florian , Kolesnik Ewald , Wallner Markus , Verheyen Nicolas , Jost Philipp J. , Zirlik Andreas , Pichler Martin , Balic Marija , Rainer Peter P. 
Published: August 2022

Background/PurposeThis study aims to quantify the utility of monitoring LVEF, hs-cTnT, and NT-proBNP for dynamic cardiotoxicity risk assessment in women with HER2+ early breast cancer undergoing neoadjuvant/adjuvant trastuzumab-based therapy.Materials and methodsWe used joint models of longitudinal and time-to-event data to analyze 1,136 echocardiography reports and 326 hs-cTnT and NT-proBNP measurements from 185 women. Cardiotoxicity was defined as a 10% decline in LVEF below 50% and/or clinically overt heart failure.ResultsMedian pre-treatment LVEF was 64%, and 19 patients (10%) experienced cardiotoxicity (asymptomatic n = 12, during treatment n = 19). The pre-treatment LVEF strongly predicted for cardiotoxicity (subdistribution hazard ratio per 5% increase in pre-treatment LVEF = 0.68, 95%CI: 0.48–0.95, p = 0.026). In contrast, pre-treatment hs-cTnT and NT-proBNP were not consistently associated with cardiotoxicity. During treatment, the longitudinal LVEF trajectory dynamically identified women at high risk of developing cardiotoxicity (hazard ratio per 5% LVEF increase at any time of follow-up = 0.36, 95% CI: 0.2–0.65, p = 0.005). Thirty-four patients (18%) developed an LVEF decline ≥ 5% from pre-treatment to first follow-up (“early LVEF decline”). One-year cardiotoxicity risk was 6.8% in those without early LVEF decline and pre-treatment LVEF ≥ 60% (n = 117), 15.9% in those with early LVEF decline or pre-treatment LVEF &lt; 60% (n = 65), and 66.7% in those with early LVEF decline and pre-treatment LVEF &lt; 60% (n = 3), (Gray’s test p &lt; 0.0001).ConclusionCardiotoxicity risk is low in two thirds of women with HER2+ early breast cancer who have pre-treatment LVEF ≥ 60% and no early LVEF decline &gt; 5% during trastuzumab-based therapy. The longitudinal LVEF trajectory but not hs-cTnT or NT-proBNP allows for a dynamic assessment of cardiotoxicity risk in this setting.
Computational approaches to alleviate alarm fatigue in intensive care medicine: A systematic literature review
Authors: Chromik Jonas , Klopfenstein Sophie Anne Ines , Pfitzner Bjarne , Sinno Zeena-Carola , Arnrich Bert , Balzer Felix , Poncette Akira-Sebastian 
Published: August 2022

Patient monitoring technology has been used to guide therapy and alert staff when a vital sign leaves a predefined range in the intensive care unit (ICU) for decades. However, large amounts of technically false or clinically irrelevant alarms provoke alarm fatigue in staff leading to desensitisation towards critical alarms. With this systematic review, we are following the Preferred Reporting Items for Systematic Reviews (PRISMA) checklist in order to summarise scientific efforts that aimed to develop IT systems to reduce alarm fatigue in ICUs. 69 peer-reviewed publications were included. The majority of publications targeted the avoidance of technically false alarms, while the remainder focused on prediction of patient deterioration or alarm presentation. The investigated alarm types were mostly associated with heart rate or arrhythmia, followed by arterial blood pressure, oxygen saturation, and respiratory rate. Most publications focused on the development of software solutions, some on wearables, smartphones, or headmounted displays for delivering alarms to staff. The most commonly used statistical models were tree-based. In conclusion, we found strong evidence that alarm fatigue can be alleviated by IT-based solutions. However, future efforts should focus more on the avoidance of clinically non-actionable alarms which could be accelerated by improving the data availability.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021233461, identifier: CRD42021233461.
Potential cellular endocrinology mechanisms underlying the effects of Chinese herbal medicine therapy on asthma
Authors: Meng Zeyu , Chen Huize , Deng Chujun , Meng Shengxi 
Published: August 2022

Asthma is a complex syndrome with polygenetic tendency and multiple phenotypes, which has variable expiratory airflow limitation and respiratory symptoms that vary over time and in intensity. In recent years, continuous industrial development has seriously impacted the climate and air quality at a global scale. It has been verified that climate change can induce asthma in predisposed individuals and that atmospheric pollution can exacerbate asthma severity. At present, a subset of patients is resistant to the drug therapy for asthma. Hence, it is urgent to find new ideas for asthma prevention and treatment. In this review, we discuss the prescription, composition, formulation, and mechanism of traditional Chinese medicine monomer, traditional Chinese medicine monomer complex, single herbs, and traditional Chinese patent medicine in the treatment of asthma. We also discuss the effects of Chinese herbal medicine on asthma from the perspective of cellular endocrinology in the past decade, emphasizing on the roles as intracellular and extracellular messengers of three substances—hormones, substances secreted by pulmonary neuroendocrine cells, and neuroendocrine-related signaling protein—which provide the theoretical basis for clinical application and new drug development.
Evolution trend and promotion potential of environmental efficiency of dairy farming in china from the perspective of “club convergence”
Authors: Xu Jiabin , Wang Jingjing , Wang Hongye , Li Cuixia 
Published: August 2022

There are differences in resource endowments, environmental regulations, and production functional areas among different regions in China, which makes dairy farming have certain heterogeneity and imbalance in pollution control, which is mainly reflected in the differences in the environmental efficiency of dairy farming among regions. By analyzing the convergence trend of the dairy farming environment in different regions and scales, it is helpful to predict the potential of improving environmental efficiency, and promote the high-quality development of dairy farming. Based on the dairy farming data of 27 provinces (cities and districts) in China from 2004 to 2019, the SBM model of unexpected output was used to measure the environmental efficiency of dairy farming on different scales. It was found that there were certain differences in the environmental efficiency of dairy farming in China. The overall environmental efficiency of dairy farming showed a “U" evolution trend, including small-scale, medium-scale, and large-scale. The average values of their environmental efficiency were 0.6859, 0.6930, and 0.6855 respectively, and the environmental efficiency of medium-scale dairy farming was the best. The convergence analysis of environmental efficiency showed that there was a conflict between the traditional σ convergence and β convergence results. However, the club convergence showed that the environmental efficiency of small-scale dairy farming converged in general, which could be further divided into two club convergence. The environmental efficiency of medium-scale and large-scale dairy farming did not converge in general but did converge in four different clubs, respectively. Taking the highest environmental efficiency value in the “club” as the reference, the potential to improve the environmental efficiency of dairy farming in different sizes was calculated. The prediction results showed that the gap between the actual value and the potential value was narrowing. It is expected that the potential to improve the environmental efficiency of dairy farming in China will remain above 10% in the next 10–20 years. Based on the above studies, this paper put forward some policy suggestions, such as changing the development direction of dairy farming, changing scale expansion to structural upgrading, implementing differentiated environmental efficiency improvement strategies, narrowing the efficiency gap between regions, paying attention to the input-output structure of factors, and improving the efficiency of breeding environment from the perspective of “eating” and " emission ".
SIRGs score may be a predictor of prognosis and immunotherapy response for esophagogastric junction adenocarcinoma
Authors: OuYang Li-Ying , Deng Zi-Jian , You Yu-Feng , Fang Jia-Ming , Chen Xi-Jie , Liu Jun-Jie , Li Xian-Zhe , Lian Lei , Chen Shi 
Published: August 2022

BackgroundEsophagogastric junction adenocarcinoma (EGJA) is a special malignant tumor with unknown biological behavior. PD-1 checkpoint inhibitors have been recommended as first-line treatment for advanced EGJA patients. However, the biomarkers for predicting immunotherapy response remain controversial.MethodsWe identified stromal immune-related genes (SIRGs) by ESTIMATE from the TCGA-EGJA dataset and constructed a signature score. In addition, survival analysis was performed in both the TCGA cohort and GEO cohort. Subsequently, we explored the differences in tumor-infiltrating immune cells, immune subtypes, immune-related functions, tumor mutation burden (TMB), immune checkpoint gene expression, immunophenoscore (IPS) between the high SIRGs score and low SIRGs score groups. Finally, two validation cohorts of patients who had accepted immunotherapy was used to verify the value of SIRGs score in predicting immunotherapy response.ResultsEight of the SIRGs were selected by LASSO regression to construct a signature score (SIRGs score). Univariate and multivariate analyses in the TCGA and GEO cohort suggested that SIRGs score was an independent risk factor for the overall survival (OS) and it could increase the accuracy of clinical prediction models for survival. However, in the high SIRGs score group, patients had more immune cell infiltration, more active immune-related functions, higher immune checkpoint gene expression and higher IPS-PD1 and IPS-PD1-CTLA4 scores, which indicate a better response to immunotherapy. The external validation illustrated that high SIRGs score was significantly associated with immunotherapy response and immune checkpoint inhibitors (ICIs) can improve OS in patients with high SIRGs score.ConclusionThe SIRGs score may be a predictor of the prognosis and immune-therapy response for esophagogastric junction adenocarcinoma.