bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Rs13118928 and Rs1828591 Polymorphisms in HHIP Gene with COPD Susceptibility: A Meta-Analysis of Case-Control Studies
Authors: Wei Xue-mei , Yang Xiao-hong 
Published: January 2022

Abstract
In recent years, investigators have been striving to explore the pathogenesis of chronic obstructive pneumonia disease (COPD). Hedgehog Interacting Protein (HHIP) has been identified as a candidate susceptibility gene. Our aim is to synthesize and include all evidences to get a more comprehensive result. We searched 6 online databases- PubMed, Web of Science, Cochrane Library, Wanfang, EMBASE, CNKI. All included studies were published before October 1, 2021. We used Newcastle-Ottawa scale (NOS) to evaluate the bias of each study. Meta-analysis methods were conducted to evaluate the pooled result. A total of 14 comparative studies were included in this meta-analysis, for rs13118928 polymorphism, significant associations were observed in 5 genetic models, (A vs. G, OR=1.18, 95CI%=[1.07-1.30], P=0.0006; AA vs. GG, OR=1.56, 95CI%=[1.22-2.00], P=0.0004; AG vs. GG, OR=1.28, 95CI%=[1.05-1.55], P=0.01; AA+AG vs. GG, OR=1.36, 95CI%=[1.12-1.65], P=0.002; AA vs. AG+GG, OR=1.18, 95CI%=[1.05-1.33], P=0.006). as for rs1828591, there were also significant associations detected in the overall population, (A vs. G, OR=1.12, 95CI%=[1.05-1.19], P=0.0003; AA vs. GG, OR=1.27, 95CI%=[1.04-1.56], P=0.02; AG vs. GG, OR=1.25, 95CI%=[1.03-1.51], P=0.02; AA+AG vs. GG, OR=1.26, 95CI%=[1.04-1.53], P=0.02; AA vs. AG+GG, OR=1.10, 95CI%=[1.01-1.19], P=0.03). This meta-analysis showed that the A allele in both rs13118928 and rs1828591 was turn out to be the risk allele in developing COPD. The result of Codominant genetic model, Dominant genetic model and Recessive genetic model remain the same.
Barriers to and Facilitators of Return to Work in Head and Neck Cancer Patients with in the First Six Months Post-Treatment
Authors: Huang Bing-Shen , Lin Chien-Yu , Chang Ya-Lan , Chung Ching-Fang , Chen Shu-Ching 
Published: January 2022

Abstract
Objective

To identify the factors associated with barriers to and facilitators of return to work (RTW) in head and neck cancer (HNC) patients in the first six months post-treatment.
Methods

This cross-sectional study examined HNC patients who completed treatment from the outpatient radiation department of a single cancer center in northern Taiwan from October 2018 to July 2020. Demographic and clinical characteristics were recorded, and patients were assessed using the Return to Work Barrier Scale, Return to Work Facilitator Scale, Distress Thermometer, Numeric Rating Scale, and Karnofsky Performance Status Scale questionnaires.
Results

Of the 106 HNC patients surveyed, 54.7% successfully RTW. Barriers to RTW included patient-perceived worst health status, greater symptom burden, and age ≥55 years. These factors explained 34.6% of the variance in overall barriers to RTW. Facilitators of RTW were lower psychological distress and who did not receive reconstruction surgery. These factors explained 17.9% of the variance in facilitators to RTW.
Conclusion

Patient-perceived health status and age most strongly influence RTW in HNC patients. HNC patients who can RTW should be encouraged to do so, and clinician awareness of potential barriers can aid patients in their RTW.
Predictors of Migration in an HIV Hyper-Endemic Rural South African Community: Evidence From a Population-Based Cohort (2005-2017)
Authors: Dzomba Armstrong , Kim Hae-Young , Tomita Andrew , Vandormael Alain , Govender Kaymarlin , Tanser Frank 
Published: January 2022

Abstract
Globally, South Africa ranks worst for people living with HIV (PLHIV) and the unique legacy of internal labour migration continues to be a major driver of the regional epidemic, interrupting treatment-as-prevention efforts. The study examined levels, trends, and predictors of migration in rural KwaZulu-Natal Province, South Africa, using population-based surveillance data from 2005 through 2017. We followed 69 604 adult participants aged 15-49 years and recorded their migration events (i.e., out-migration from the surveillance area) in 423 038 person-years over 525 397 observations. Multiple failure Cox-regression models were used to measure the risk of migration by socio-demographic factors: age, sex, educational status, marital status, HIV, and community antiretroviral therapy (ART) coverage. Overall, 69% of the population cohort experienced at least one migration event during the follow-up period. The average incidence rate of migration was 9.96 events and 13.23 events per 100 person-years in women and men, respectively. Migration rates declined from 2005 to 2008 then peaked in 2012 for both women and men. Adjusting for other covariates, the risk of migration was 3.4-times higher among young women aged 20-24 years compared to those aged ≥40 years (adjusted Hazard Ratio [aHR]=3.37, 95% Confidence Interval [CI]: 3:19-3.57), and 2.9-times higher among young men aged 20-24 years compared to those aged ≥40 years (aHR=2.86, 95% CI:2.69-3.04). There was a 9% and 27% decrease in risk of migration among both women (aHR=0.91, 95% CI: 0.83 – 0.99) and men (aHR=0.73, 95% CI 0.66 – 0.82) respectively per every 1% increase in community ART coverage. Young unmarried women including those living with HIV, migrated at a magnitude similar to that of their male counterparts, and lowered as ART coverage increased over time, reflecting the role of improved HIV services across space in reducing out-migration. A deeper understanding of the characteristics of a migrating population provides critical information towards identifying and addressing gaps in the HIV prevention and care continuum in an era of high mobility.
The Impact of COVID-19 On Emergency Visits For Back And Neck Pain
Authors: Ohana Nissim , Engel Itzhak , Baruch Yuval , Benharroch Daniel , Sheinis Dimitri 
Published: January 2022

Abstract
Purpose: To assess the rate of visits to the emergency department of our medical center concerning low back or neck pain, as a factor of COVID-19 confinements.Methods: The study period was a 30-weeks interval during the COVID-19 pandemic contrasted by a similar stretch in the year preceding the epidemic. The visits to the Emergency Department, prompted by low back or neck pain, were recorded prior and during lockdowns of the pandemic. The significance of the confinements for the development of the pain syndromes was evaluated.Results: A total of 1530 patients with newly diagnosed back or neck pain were enrolled. Most patients visited our emergency department for low back pain, commonly those older than 60 years. No significant gender variance was disclosed, though most visits of females were for low back pain. Low back pain presentations were curbed following confinement, but the rate of stays for neck pain had swelled by more than 10%. Despite back pain predominance, visits for neck pain persisted. Before COVID-19, the average weekly number of Emergency Department visits was 38.5. This was followed by sharp drops during COVID-19 lockdown (mean different=-22.2, 95%CI=-28.7, -15.7, p<0.001) (not significant).Conclusions: COVID-19 lockdowns have a significant impact on the Emergency Department’s presentations due to back and neck pain. A higher rate of presentation for back pain compared to neck pain is probably related to COVID-19, without being affected directly by the SARS-CoV-2: confinement-induced immobility might instigate musculoskeletal sequels, which may be attributed to stress or other psycho-social afflictions.
Quality Control of Mitochondria in Parkinson's Disease (PD) Using ATP And Bradford Assays
Authors: Akram Al-Baraa 
Published: January 2022

Abstract
Parkinson's disease is a heterogeneous, multifactorial and often complex disease characterized by motor impairment due to the presence of Lewy bodies and prominent degeneration of dopaminergic neurons in the substantia nigra. Although the specific pathogenesis involving PD remains under investigation, mitochondrial dysfunction has been widely accepted as one of the major pathogenic pathways underlying the development of PD. Based on the hypothesis that depiction of HtrA2 (serine protease gene, mitochondrial precursor) might contribute to an increase in mitochondrial stress and transcriptional upregulation of the nuclear stress-response CHOP gene. The present study aimed to analyze through laboratory-based research the role of HtrA2 and CHOP in the transmission of stress signaling and the consequent activation of mitochondrial quality control in Parkinson's disease using ATP and Bradford assays.
Exploring Influencing Factors of Chronic Obstructive Pulmonary Disease Based on Elastic Net and Bayesian Network
Authors: Quan Dichen , Ren Jiahui , Ren Hao , Linghu Liqin , Wang Xuchun , Li Meichen , Qiao Yuchao , Ren Zeping , Qiu Lixia 
Published: January 2022

Abstract
This study aimed to construct Bayesian networks(BNs) to analyze the network relationship between those influencing factors and COPD, and to explore their intensity of effect on COPD through network reasoning. Elastic Net and Max-Min Hill-Climbing(MMHC) hybrid algorithm were adopted to screen the variables on the monitoring data of COPD among residents in Shanxi Province, China from 2014 to 2015, and construct BNs respectively. After variables selection by Elastic Net, 10 variables closely related to COPD were selected finally. The BNs constructed by MMHC showed that smoking status, household air pollution, family history, cough, air hunger or dyspnea were directly related to COPD, and Gender was indirectly linked to COPD through smoking status. Moreover, smoking status, household air pollution and family history were the parent nodes of COPD, and cough, air hunger or dyspnea represented the child nodes of COPD. In other words, smoking status, household air pollution and family history were related to the occurrence of COPD, and COPD would make patients’ cough, air hunger or dyspnea worse. Generally speaking, BNs could reveal the complex network relationship between COPD and its relevant factors well, making it more convenient to carry out targeted prevention and control of COPD.
An efficient 2-aminothiazolesalicylaldehyde Fluorescent Chemosensor for Fe2+ ion Detection and Potential Inhibitor of NUDT5 Signaling Hormone for Breast Cancer Cell and Molecular Keypad Lock Application
Authors: Basha Summaya Banu , Charles Immanuel David , Raju Nandhakumar , Manokaran Sakthivel , Kuzhandaivel Hemalatha 
Published: January 2022

Abstract
A novel thiazole phenol conjugate 2-aminothiazolesalicylaldehyde (receptor1) was designed and synthesized for the first time through a single step process via schiff base condensation reaction. The formation of receptor1 was confirmed by FTIR, 13C NMR and 1H NMR. The receptor1 complexing with various metal ions studied through fluorescence spectroscopy showed its selectivity towards Fe2+ ion following a reverse photo induced electron transfer (PET) process compared to all other potentially competing ions. Furthermore, the receptor1 showed excellent reversibility property on adding EDTA solution. The binding affinity between receptor1-Fe2+ ion was found to be Ka = 2.22x102 M-1 and the sensing affinity of receptor1 towards Fe2+ ion at nanolevel concentration was 33.7x10-9 M which is lower than the detection limit of existing Schiff base. The receptor1 was used to detect Fe2+ ion in different water samples. Using molecular docking the chelating function of ligand (receptor1) was assessed as a potential inhibitor of NUDT5, a silence hormone signaling for breast cancer. The excellent reversibility property is used to construct INHIBIT molecular logic gate.
Mesothelin-Specific T Cell Cytotoxicity Against Triple Negative Breast Cancer Is Enhanced By 40s Ribosomal Protein Subunit 3-Treated Self-Differentiated Dendritic Cells
Authors: Jirapongwattana Niphat , Thongchot Suyanee , Chiraphapphaiboon Wannasiri , Chieochansin Thaweesak , Sa-nguanraksa Doonyapat , Warnnissorn Malee , Thuwajit Peti , Yenchitsomanus Pa-Thai , Thuwajit Chanitra 
Published: January 2022

Abstract
Purpose Triple negative breast cancer (TNBC) is deficient in targeted treatment resulting in poor prognosis. Targeting overexpressed mesothelin (MSLN) using MSLN-specific T cells is an attractive treatment approach.Methods The immunohistochemistry of MSLN in TNBC tissues were performed. A lentiviral vector harboring granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-4 (IL-4) and MSLN cDNAs was constructed to generate self-differentiated myeloid-derived antigen-presenting-cells reactive against tumor expressing MSLN dendritic cells (MSLN-SmartDC) for MSLN-specific T cell activation. The antigen specificity and cancer killing of activated T cells were accessed.Results The high expression of MSLN was found in 32.8% all breast cancer subtypes and 57% in TNBC. High MSLN was significantly associated with the TNBC subtype and the absence of ER, PR and HER2. MSLN-SmartDC exhibited comparable phenotype to DC generated by exogenous cytokine treatment; addition of 40s ribosomal protein subunit 3 (RPS3), a toll-like receptor 4 ligand, enhanced DC maturation and function by upregulation of CD40, CD80 and CD83 expression and IL-12p70 secretion. MSLN-specific CD8+CD69+ IFN-γ+ T cells were detected in T cells activated by both MSLN-SmartDC and RPS3-MSLN-SmartDC. MSLN-specific T cells activated by these DCs showed more specific killing capability against naturally expressed MSLN-HCC70 and artificially MSLN-overexpressing MDA-MB-231 compared to parental MDA-MB-231 in both 2 dimensional (2D)- and 3D-culture systems. Conclusion High MSLN was observed in TNBC patients, a potential target for TNBC treatment. MSLN-SmartDC could promote MSLN-specific T cell response against TNBC and RPS3 can enhance the cytolytic activity of these T cells providing an alternative treatment approach for TNBC patients.
How to Anticipate Public Health Indicators Using Wastewater SARS-CoV-2 Concentration During the COVID-19 Pandemic. Madrid Region Case Study
Authors: Lastra Antonio , Botello Jaime , Pinilla Alejandro , Canora Jesús , Sánchez Juan , Urrutia Iñaki , Fernández Pascual , Zapatero Antonio , Candel Francisco Javier , Ortega Mónica , Ortega Celia 
Published: January 2022

Abstract
This study analyzes the presence and dynamics of SARS-CoV-2 in sewage sanitation systems in the Madrid region. The statistical results and data generated are presented daily via a platform as a tool for the early detection of SARS-CoV-2 and its spread based on the WBE (wastewater-based epidemiological) approach. The number of sampled points amounts to a total of 289 sampling points in terms of SARS-CoV-2 concentration that collects over six million and a half inhabitants’ discharges. The project was developed by Canal de Isabel II, the water utility company from Madrid. The research evaluates the correlation found between SARS-CoV-2 concentration in wastewater and the following public health indicators: incidence rate, reported active cases and COVID-19 hospitalization data (regular hospitalization and ICU admission cases).SARS-CoV-2 presence and dynamics in wastewater show a strong connection with both 14-day incidence rates with active infection and reported COVID-19 hospitalizations. A lag varying from 3 to 8 days between wastewater presence and hospitalizations is explained because the infection is found in the feces of patients before symptom onset. The resulting data are available for consultancy on the company’s website (named VIGÍA project) as well as on the regional government’s websites.The results have already been useful to anticipate the second and third COVID-19 waves in Madrid. Information is shared daily with health authorities for consultancy and decision-making. The results are available as an aggregation for the entire region and for each sewershed.
Analysis of Sustainability In Livestock Production Systems In Cordoba, Colombia.
Authors: Nobles Yhonattan Mendez , Rocha Alfonso Acevedo , Farreras Jordi Morató , Manchego Katy Pacheco , Padilla Sharon Martínez , Lorduy Jorge Villadiego 
Published: January 2022

Abstract
The concept of sustainability is usually broad; it refers to the ability of the system to meet the current demand for livestock products without compromising the use of resources by future generations. Therefore, this study has been conducted to provide an overview of rotational, intensive, and regenerative livestock models to evaluate and measure their level of sustainability in the environmental, social, and economic dimensions to guide livestock guilds, professionals and stakeholders to transform their agricultural systems by adopting the concept of sustainability. The results show that the regenerative livestock system has a high association with the economic dimension in the Almost Good category, in the environmental dimension in the Moderate category, and in the social dimension in the Almost Good and Very Good categories. On the other hand, the rotational livestock system and the intensive livestock system have an association with the environmental dimension categorized as good; however, the association of the intensive livestock system is not as strong as that of the rotational livestock system.
COVID-19 Vaccine Perceptions in the Initial Phases of US Vaccine Roll-out: An Observational Study on Reddit
Authors: Kumar Navin , Corpus Isabel , Hans Meher , Harle Nikhil , Yang Nan , McDonald Curtis , Sakai Shinpei Nakamura , Janmohamed Kamila , Chen Keyu , Altice Frederick L. , Tang Weiming , Schwartz Jason L. , Jones-Jang S. Mo , Saha Koustuv , Memon Shahan Ali , Bauch Chris T. , De Choudhury Munmun , Papakyriakopoulos Orestis , Tucker Joseph D. , Goyal Abhay , Tyagi Aman , Khoshnood Kaveh , Omer Saad 
Published: January 2022

Abstract
Background: Open online forums like Reddit provide an opportunity to quantitatively examine COVID-19 vaccine perceptions early in the vaccine timeline. We examine COVID-19 misinformation on Reddit following vaccine scientific announcements, in the initial phases of the vaccine timeline. Methods: We collected all posts on Reddit from January 1 2020 - December 14 2020 (n=266,840) that contained both COVID-19 and vaccine-related keywords. We used topic modeling to understand changes in word prevalence within topics after the release of vaccine trial data. Social network analysis was also conducted to determine the relationship between Reddit communities (subreddits) that shared COVID-19 vaccine posts, and the movement of posts between subreddits. Results: There was an association between a Pfizer press release reporting 90\% efficacy and increased discussion on vaccine misinformation. We observed an association between Johnson and Johnson temporarily halting its vaccine trials and reduced misinformation. We found that information skeptical of vaccination was first posted in a subreddit (r/Coronavirus) which favored accurate information and then reposted in subreddits associated with antivaccine beliefs and conspiracy theories (e.g. conspiracy, NoNewNormal). Conclusions: Our findings can inform the development of interventions where individuals determine the accuracy of vaccine information, and communications campaigns to improve COVID-19 vaccine perceptions, early in the vaccine timeline. Such efforts can increase individual- and population-level awareness of accurate and scientifically sound information regarding vaccines and thereby improve attitudes about vaccines, especially in the early phases of vaccine roll-out. Further research is needed to understand how social media can contribute to COVID-19 vaccination services.
Efficacy of Complete Laparoscopic Ileal Augmentation Cystoplasty for the Treatment of Low Bladder Capacity and Compliance: a Case Series
Authors: Yang Chao , Chen Xin , Wang Yi , Fang Lu , Sun Wei , Bi Liangkuan , Yu Dexin 
Published: January 2022

Abstract
Objectives: To investigate the safety and efficacy of complete laparoscopic ileal augmentation cystoplasty for the treatment of low bladder capacity and compliance.Methods: The clinical data of 13 patients with low bladder capacity and compliance were retrospectively analyzed. Therapeutic efficacy was evaluated at follow-up. The Clavien system was used to evaluate the severity of postoperative complications.Results: All 13 operations were successfully completed laparoscopically. The operation duration was 140-248 min (average: 189.9 ± 29.6 min), the time to postoperative recovery of bowel function was 1-10 days (average: 2.9 ± 2.3 days). There were 4 cases of grade I complications and 1 case of grade II complications (i.e., paralytic ileus caused by urinary leakage from the anastomosis of the augmented bladder). Cystography showed that the morphology of the bladder was close to normal, and the maximum safe capacity and compliance of the bladder were significantly increased [103.8 ± 16.6 mL and 332.3 ± 20.5 mL, p < 0.01; 7.0 ± 1.3 mL/cm H2O and 32.4 ± 2.1 mL/cm H2O, p < 0.01]. All patients were able to urinate spontaneously after catheter removal.Conclusions: Complete laparoscopic ileal augmentation cystoplasty is a safe and feasible treatment for low bladder capacity and compliance, and has the advantages of less trauma, less bleeding, faster recovery of intestinal function, and fewer postoperative complications. This treatment effectively increases bladder capacity, protects upper urinary tract function, and improves patient quality of life, and thus warrants clinical application.
Palliative Radiotherapy for Gastric Cancer Bleeding: A Multi-Institutional Retrospective Study.
Authors: Takeda Kazuya , Sakayauchi Toru , Kubozono Masaki , Katagiri Yu , Umezawa Rei , Yamamoto Takaya , Ishikawa Yojiro , Takahashi Noriyoshi , Suzuki Yu , Kishida Keita , Jingu Keiichi 
Published: January 2022

Abstract
Background: Palliative radiotherapy for gastric cancer bleeding has been reported to be a safe and effective treatment, but predictive factors for achievement of hemostasis and overall survival have not been established.Methods: In this retrospective study, 120 courses of palliative radiotherapy for gastric cancer bleeding in 117 patients in 4 institutes in Japan were reviewed with approval of the ethical committee in each institute. The rate of achieving hemostasis was evaluated by 50% or more reduction of red blood cell transfusion before and after the start of radiotherapy, elevation of blood hemoglobin concentration in a period of 4 weeks from the start of radiotherapy or improvement of subjective or objective clinical symptoms in a period of 4 weeks from the start of radiotherapy. Predictive factors for overall survival and achieving hemostasis were investigated with the Cox hazards model.Results: The median overall survival period was 3.7 months. Multivariate analysis showed that absence of metastatic disease, higher biological effective dose, higher serum albumin level, lower blood urea nitrogen level and lower neutrophil-to-lymphocyte ratio (NLR) were associated with longer overall survival. Elevation of hemoglobin concentration in a period of 4 weeks from the start of radiotherapy (mean concentration: 8.2 g/dL vs. 8.9 g/dL, p=0.006) and decrease in the amount of red cell transfusion from a 4-week period before to a 4-week period after the start of radiotherapy (mean amount: 716 mL vs. 230 mL, p<0.0001) were observed. The overall rate of achievement of hemostasis was 59.6%. In multivariate analysis, higher biological effective dose was associated with achievement of hemostasis. Grade 2 or higher acute adverse effects related to radiotherapy were observed in 17.5% of cases in 120 treatment courses. Six cases (5.0%) had grade 3 or 4 adverse effects including gastric penetration in 1 patient and anorexia requiring total parental nutrition in 3 patients. No grade 5 adverse effects were observed.Conclusions: Palliative radiotherapy for gastric cancer bleeding seems to be an effective and safe treatment strategy. Higher treatment dose was associated with longer overall survival and a hemostatic effect. Some hematological parameters may predict overall survival, and they would be helpful for deciding the treatment strategy.