bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic Omental Flap Partial Breast Reconstruction
Authors: Tang Siau Wei 
Published: November 2022

AbstractOncoplastic breast surgery combines oncological resection of a breast malignancy with plastic surgical techniques for immediate reconstruction of the defect using volume replacement or volume displacement techniques. As breast-conserving surgery increases in popularity, partial breast reconstruction using volume replacement techniques has evolved to allow excision of larger tumors while minimizing cosmetic deformity. Lateral chest wall perforator flaps (thoracodorsal artery perforator (TDAP) flap and the lateral intercostal artery perforator (LICAP) flap) are commonly used for tumors in the outer half of the breast; superior epigastric artery perforator (SEAP) flaps are commonly used for lower inner quadrant tumors. Upper inner quadrant defects present a challenge for volume replacement in partial breast reconstruction as there are limited options for local flaps and would require adequate mobilization for a longer pedicle if perforator flaps are utilized.
Gastroesophageal Reflux Disease
Authors: Frankel Adam , Smithers B. Mark 
Published: November 2022

AbstractGastroesophageal reflux disease (GORD) is defined as troublesome symptoms and/or injury to the oesophageal mucosa consistent with acid exposure [1]. GORD is common, with an age-adjusted global prevalence of 9% but significant variation across the world [2]. The diagnosis can often be made on clinical grounds and is more likely if there is at least a partial response to a proton pump inhibitor (PPI) [3]. Indications for oesophageal testing have been recently updated in international consensus guidelines, which include guidelines where diagnosis is not clearly established [4]. Fundoplication is the use of the gastric fundus to create a high-pressure zone on or around the lower oesophagus and is usually performed laparoscopically. It can be considered in terms of the completeness of the wrap (generally from 90 to 360°), and if less than 360°, whether the wrap is brought anterior to the oesophagus, posterior, or both. The efficacy and side effect profiles of many of the approaches have been subjected to randomised trials: anterior 90 vs 360° [5]; anterior 180 vs 360° [6]; and posterior 270 vs 360° [7]. The relative merits of each have been recently reviewed by Morino and colleagues [8]. Fundoplication is at least as safe and effective as PPI in relieving the symptoms of GORD [9]. For PPI-refractory GORD, fundoplication is more effective than escalating medical therapy [10].
Electrosurgery and Energy Devices
Authors: Malik Sajid , Khairi Farah , Wijerathne Sujith 
Published: November 2022

AbstractEnergy and surgery have evolved together so closely that in the modern era, even thinking of doing surgery without energy has become nearly impossible. There are many types of energy devices available to be used today but to use them safely, the knowledge on the principles of surgical energy and safety is important.
Laparoscopic Sleeve Gastrectomy
Authors: Malik Sajid , Wijerathne Sujith 
Published: November 2022

AbstractBariatric surgery (BS) has proved its role in treating obesity and related comorbidities. The number of Laparoscopic Sleeve Gastrectomies (LSGs) performed globally has increased markedly and has become “trendy” among bariatric surgeons in the last few years [1]. LSG has attained its position as the primary procedure of choice in bariatric surgery for morbid obesity. In this procedure, 80% of the stomach, mainly the body and fundus are removed longitudinally, leaving behind a sleeve of the stomach along the lesser curve [2, 3]. The procedure can be performed by minimally invasive approaches as well as single incision access or even robotic surgery with comparable results [4, 5]. The weight loss is achieved by restricting the food entering the stomach. Another factor in the effectiveness of weight loss in sleeve gastrectomy is the decrease in blood levels of ghrelin, “the hormone that stimulates hunger,” and a majority of cells responsible for producing this hormone is found in the fundus which is removed during this procedure. This procedure can be performed as the first stage in more complex bariatric cases including cases of super-obesity before procedures like Roux-en-Y gastric bypass or the duodenal switch can be performed [6]. The objective is to achieve an initial weight loss that would help to perform more extensive mixed restrictive or malabsorptive procedures safely and effectively [7–9].
Laparoscopic Distal Pancreatectomy
Authors: Hai Pham Minh , Tuan Le Quan Anh 
Published: November 2022

AbstractDistal pancreatectomy (DP) consists of standard DP (with or without splenic preserving) and Radical antegrade modular pancreatosplenectomy (RAMPS). The former is also called DP. The latter is indicated for malignant or suspected malignant tumors. Both can be performed via laparoscopic or open approach.
Laparoscopic Splenectomy
Authors: Fuentes Marilou B. , Lomanto Davide 
Published: November 2022

AbstractLaparoscopic splenectomy has gained popularity as an option for patients having benign and malignant diseases as well as for trauma patients who are stable. Studies have shown that this procedure is prone to bleeding but with advanced technology and good anatomical knowledge of vasculature, the procedure is not only feasible but can be performed safely. Poulin who did the first laparoscopic partial splenectomy for ruptured spleen in 1995 proved it was possible. The inherent abundant blood supply and proximity of spleen to vital organs make it prone to 5–60% complication during its dissection, and hence utmost care and skills are needed during surgery [1].
Laparo-Endoscopic Approach to Complex Inguinal Hernia [Inguinoscrotal Hernias: Sliding Hernias]
Authors: Gupta Rakesh Kumar , Lomanto Davide 
Published: November 2022

AbstractVery few surgical entities have fascinated surgeons over centuries than the complexity of inguinal hernia repair. Despite being one of the commonest procedures performed, the surgical fraternity all over the world is still in the quest for the final word on the best type of repair. Similarly, treatment of complex groin hernia remains the same [1]. Complex groin hernia can be defined as those with large size, e.g., inguinoscrotal hernia, sliding hernia, multiple recurrences, infected mesh and strangulation, etc. The approach to these hernias involves a great deal of preoperative preparations and decision-making that is carried through the operation and postoperative period. The laparoscopic approach in these cases is feasible and with good outcomes provided that the surgeon adheres to three M’s; mastery of the anatomy, meticulous dissection, and modus operandi [2]. No wonder hundreds of procedures have been described for the treatment of complex groin hernia. There has been always a concern about whether complex groin hernia can be treated with laparoscopy or not but more favorable outcomes have been found with laparoscopy than in open surgery [1].
Laparoscopic Parastomal Hernia Repair
Authors: Seow-En Isaac , Tsai Yuan-Yao , Chen William Tzu-Liang 
Published: November 2022

AbstractParastomal hernia is an incisional hernia resulting from an abdominal wall stoma creation [1]. The published incidence of parastomal hernia varies widely, with 2–28% and 4–48% affecting end ileostomies and end colostomies, respectively, depending on the severity of the hernia, method of diagnosis, and the duration of follow-up [2]. Loop stomas have a much lower incidence of parastomal herniation, as these tend to be reversed before a hernia can develop. The risk of herniation is cumulative with time but appears to be highest within 2 years of ostomy formation. Most patients are asymptomatic or have mild complaints such as intermittent discomfort or sporadic obstructive symptoms, but many eventually have symptoms significant enough to warrant surgical intervention, including incarceration, strangulation, and perforation. The bulging around the stoma can also cause result in difficulty applying the stoma appliance, resulting in leakage and skin irritation [2].
Exercise Stress Echocardiography in Kawasaki Disease Patients with Coronary Aneurysms
Authors: Tedla Bruke A. , Burns Jane C. , Tremoulet Adrianna H. , Shimizu Chisato , Gordon John B. , El-Said Howaida , Golding Fraser , Davis Christopher K. , Dummer Kirsten B. 
Published: November 2022

AbstractThe most significant sequelae of Kawasaki disease (KD) are coronary artery aneurysms, which can lead to risk of future myocardial ischemia. Exercise stress echocardiography allows for non-invasive assessment of myocardial dysfunction. We reviewed our single center experience with exercise stress echocardiography in patients with previous history of KD with coronary aneurysms. We reviewed the records of 53 KD patients who underwent exercise stress echocardiography from 2000 to 2020. Abnormal stress echocardiograms were defined as those showing no increase in biventricular systolic function post-exercise or regional wall motion abnormalities. Computed tomography angiography and cardiac magnetic resonance imaging were reviewed for patients with abnormal stress echocardiograms. Clinical data were reviewed and correlated with stress echocardiogram results. Of the 53 patients, three (5.7%) had an abnormal exercise stress echocardiogram. All three patients were classified as AHA Risk Level 4 or 5 by coronary Z-score (internal dimension normalized for body surface area) and were confirmed to have coronary aneurysms, stenosis, or myocardial tissue perfusion defects on advanced cardiac imaging that could account for the results seen on stress echocardiogram. Exercise stress echocardiography detected signs of myocardial ischemia in a subset of high-risk patients with Kawasaki disease and coronary aneurysms and may be considered as a useful screening tool for this complex patient cohort.
Analysis of second order properties of production–inventory systems with lost sales
Authors: de la Cruz Nha-Nghi , Daduna Hans 
Published: November 2022

AbstractWe consider a single-item production–inventory system under a base stock policy for inventory control. We model the system as a closed Gordon–Newell network. The population size of the network is equal to the base stock level, which is the sum of the finished goods and work-in-process inventory. Each exogenous demand, which follows a Poisson process, releases a production order for a new unit and increases the amount of the work-in-process inventory. When there are no items in the finished goods inventory available, arriving demand is lost. The replenishment network operates with state dependent service rates, which we assume to be increasing and concave. First, we analyze the queue length behavior of a two node system and provide conditions under which the mean queue length at the production server is convex in the number of customers in the system. We prove that this leads to convexity of a standard cost function. Using Norton’s theorem, we are able to generalize our results for arbitrarily large production–inventory systems.
BT595, a 10% Human Normal Immunoglobulin, for Replacement Therapy of Primary Immunodeficiency Disease: Results of a Subcohort Analysis in Children
Authors: Kriván Gergely , Borte Michael , Soler-Palacin Pere , Church Joseph A. , Csurke Ildiko , Harris James B. , Lieberman Jay A. , Melamed Isaac R. , Moy James N. , Simon Reka , Aigner Silke , Lentze Stephan , Staiger Christiane 
Published: November 2022

Abstract

Purpose
To assess the efficacy, pharmacokinetics, and safety of a new, highly purified 10% IVIg (BT595, Yimmugo®) administered in children with PID.

Methods
This was an open-label, prospective, uncontrolled, multicenter Phase III pivotal trial. Among the 67 subjects in the trial were 18 pediatric patients aged 2 to 17 years with diagnosis of PID included in this analysis. They received doses between 0.2 and 0.8 g/kg body weight for approximately 12 months at intervals of either 3 or 4 weeks. Dosage and dosing interval were based on each patient’s pre-trial infusion schedule. The rates of acute serious bacterial infections (SBI), secondary efficacy, safety, and pharmacokinetic outcomes were evaluated.

Results
No SBI occurred in the pediatric population. Two hundred sixty infusions were administered to the 18 pediatric patients. The mean (SD) IgG trough level was 8.55 (1.67) g/L at baseline and 8.84 (2.17) g/L at the follow-up visit after the last BT595 infusion. At the single infusions respectively, the average mean IgG trough levels ranged between 8.52 and 10.58 g/L. More than 85% of all infusions administered were not associated with any infusional AE (start during or within 72 h post-infusion). None of the severe or serious AEs were related to the investigational medicinal product (IMP). No premedication was used. Thirteen children reached a maximum infusion rate between > 2.0 and 8 mL/kg/h; no AE with an onset during the infusion occurred at these infusion rates.

Conclusion
BT595 is effective, convenient, well tolerated, and safe for the treatment of children with PID.

Trial registration
EudraCT: 2015–003652-52; NCT02810444, registered June 23, 2016.
Elementary school children’s perceptions of geometry classroom as a psychosocial learning environment: an analysis of participant-produced drawings
Authors: Kuzle Ana 
Published: November 2022

AbstractA growing literature points to the importance of classroom social climate as one of the determinants of students’ academic performance and motivation, engagement, participation, and attitude towards school and teaching. However, little attention is given to social climate in the context of the mathematics classroom as a learning environment, with studies providing only insights into its specific aspects. The present study addressed these problems by investigating classroom social climate in the context of geometry lessons in Grades 3–6 with the goal of providing comprehensive insight into students’ perceptions of their geometry classroom climate by identifying its psychosocial aspects. In total, 114 primary-grade students participated in the qualitative cross-sectional study. To capture students’ perceptions of their geometry classroom, participant-produced drawings were used as a research method. These were analyzed using qualitative content analysis. The results reflected a teacher-centered image of a geometry learning environment which was driven by frontal work with a broad spectrum of participatory activities, but with very little student–student communication. Additionally, the lesson goals were transparent which were supported by using different teaching tools and materials. Lastly, the lessons were organized in an orderly manner. The findings offer potential opportunities for educators to plan and implement effective pedagogical strategies at the university that would reflect the teaching practices conducive to geometry learning. Likewise, the research method can be used in classroom learning environments as a tool to promote a dialogue between students and their teachers.
Children with medical complexities: their distinct vulnerability in health systems’ Covid-19 response and their claims of justice in the recovery phase
Authors: Lignou Sapfo , Sheehan Mark 
Published: November 2022

AbstractIn this paper, we discuss the lack of consideration given to children in the COVID-19 health systems policy response to the pandemic. We do this by focusing on the case of children with complex medical needs. We argue that, in broad terms, health systems policies that were implemented during the pandemic failed adequately to meet our obligations to both children generally and those with complex medical needs by failing to consider those needs and so to give them fair protection against harm and disadvantage. We argue that justice requires that the distinct needs and vulnerabilities of children with medical complexities are explicitly integrated and prioritised in decisions concerning healthcare and operational planning in the recovery phase and beyond.
On the life cycles of successful rock bands
Authors: Franses Philip Hans 
Published: November 2022

AbstractA typical feature of life cycles of rock bands is that they seem to consist of two distinct stages. A first stage associates with initial entry and a second stage seems to be related to more mainstream success. This paper proposes a simple model to describe these two stages in the life cycles. The model is put to an empirical test by analyzing the numbers of annual shows of forty-nine heavy metal bands. It is found that initial peak success is attained, on average, after seven years, and that the second wave of success occurs after twenty years, again on average. The second peak associates with twice as much success as the first.
The bidirectional longitudinal association between health-related quality of life and academic performance in adolescents: DADOS study
Authors: Adelantado-Renau Mireia , Monzonís-Carda Irene , Moliner-Urdiales Diego , Beltran-Valls Maria Reyes 
Published: November 2022

Abstract
Purpose
Although previous evidence has suggested a relationship between health-related quality of life (HRQoL) and academic performance, the directionality of this association is understudied and remains to be clarified. Thus, the primary objective of this study was to explore the bidirectional association between HRQoL and academic performance in adolescents between two timepoints with a 24-month interval. A secondary aim was to analyze whether this association varies between boys and girls.

Methods
This is a bidirectional longitudinal analysis with 257 adolescents (13.9 ± 0.3 years at baseline) from the DADOS study. HRQoL was measured using the KIDSCREEN-10 questionnaire. Academic performance was assessed through academic grades and the Spanish version of the Science Research Associates Test of Educational Ability.

Results
Cross-lagged analyses revealed that HRQoL at baseline was not associated with academic performance 24 months later, while all the academic grades and the overall score of academic abilities at baseline were positively associated with HRQoL at follow-up in adolescents. Results of the stratified analyses by sex were largely similar. Specifically, in girls, math, language, physical education, and grade point average at baseline were positively associated with HRQoL 24 months later, while in boys, all the academic grades indicators (except physical education), numeric ability, and the overall score of academic abilities at baseline were positively associated with HRQoL at follow-up.

Conclusion
These findings suggest that academic performance in early adolescence may predict HRQoL 24 months later. Health and education professionals could benefit from collaborating to achieve both improved academic performance and HRQoL in youth.
Effects of the COVID-19 pandemic on reading performance of second grade children in Germany
Authors: Förster Natalie , Forthmann Boris , Back Mitja D. , Souvignier Elmar 
Published: November 2022

AbstractIn education, among the most anticipated consequences of the COVID-19 pandemic are that student performance will stagnate or decline and that existing inequities will increase. Although some studies suggest a decline in student performance and widening learning gaps, the picture is less clear than expected. In this study, we add to the existing literature on the effects of the COVID-19 pandemic on student achievement. Specifically, we provide an analysis of the short- and mid-term effects of the pandemic on second grade reading performance in Germany using longitudinal assessments from over 19,500 students with eight measurement points in each school year. Interestingly, the effects of the pandemic established over time. Students in the first pandemic cohort even outperformed students from the pre-pandemic cohorts and showed a tendency towards decreased variances during the first lockdown. The second pandemic cohort showed no systematic mean differences, but generally had larger interindividual differences as compared to the pre-pandemic cohorts. While the gender achievement gap seemed unaffected by the pandemic, the gap between students with and without a migration background widened over time—though even before the pandemic. These results underline the importance of considering effects of the pandemic across cohorts, large samples, and fine-grained assessments. We discuss our findings considering the context-specific educational challenges and in terms of practical implications for teachers’ professional development.
Studying Legal Persuasion and Emotion in Spanish and English: An Advocate General’s Dismissal of the Rule-of-law Challenge by Hungary and Poland
Authors: Orts María Ángeles 
Published: November 2022

AbstractThe present work examines the role of persuasive lexicon in legal discourse through the analysis of emotional devices at a lexical and rhetorical level. Our preliminary premise is that emotion is deployed by experts to convey the sentiment of shared values and epistemic trust: the need to rely on the tenets of the law as fair and conducive to the common good. The corpus of our study is constituted by the conclusions in their original Spanish, and their translation into English, by the Advocate General Manuel Campos on the challenge by Hungary and Poland of the regulation establishing a “conditionality regime” in the event of a rule-of-law breach in a EU Member State. To this end, we undertake a two-pronged analysis of legal persuasion to find out what emotional devices are deployed to convey the rule-of-law principles of justice, non-discrimination, equality and solidarity. At a first stage, we concentrate upon the polarity and intensity of emotion words and their categories. Emotional implicatures in the shape of legal technolects and metaphorical ontologies and the way they are deployed in each text constitutes the second part of our study. Among our conclusions are that both the original and target texts have a strong persuasive character, mainly grounded in the negative emotion of fear and the positive emotion of trust, and that there are variances in the emotional language deployed in either version due to the different mechanics of each law system and to functional differences between English and Spanish.
Changepoint detection in non-exchangeable data
Authors: Hallgren Karl L. , Heard Nicholas A. , Adams Niall M. 
Published: November 2022

AbstractChangepoint models typically assume the data within each segment are independent and identically distributed conditional on some parameters that change across segments. This construction may be inadequate when data are subject to local correlation patterns, often resulting in many more changepoints fitted than preferable. This article proposes a Bayesian changepoint model that relaxes the assumption of exchangeability within segments. The proposed model supposes data within a segment arem-dependent for some unknown$$m \geqslant 0$$m⩾0that may vary between segments, resulting in a model suitable for detecting clear discontinuities in data that are subject to different local temporal correlations. The approach is suited to both continuous and discrete data. A novel reversible jump Markov chain Monte Carlo algorithm is proposed to sample from the model; in particular, a detailed analysis of the parameter space is exploited to build proposals for the orders of dependence. Two applications demonstrate the benefits of the proposed model: computer network monitoring via change detection in count data, and segmentation of financial time series.