bluuebunny/crossref_metadata_2025_split huggingface dataset:
Підходи щодо розроблення методики імплементації концептуальних документів стратегічного та оборонного планування
Authors: Поляєв А. 
Published: May 2022

Одним з важливих пріоритетів реалізації державної політики у сфері оборони є виконання завдання з імплементації концептуальних нормативно-правових актів взаємоузгоджених з іншими документами оборонного планування в системи оборонного менеджменту Міністерства оборони України та Збройних Сил України. Саме тому, вважається актуальним і невідкладним завдання щодо визначення підходів до розроблення методики імплементації концептуальних документів стратегічного та оборонного планування в Міністерстві оборони України та Збройних Силах України з урахуванням досвіду держав-членів НАТО.
Під імплементацією концептуальних документів стратегічного та оборонного планування у даній статі розуміється сукупність цілеспрямованих організаційно-правових та інституційних заходів, які здійснюються в Міністерстві оборони України та Збройних Силах України і спрямованих на реалізацію державної політики у сфері оборони, що визначена законами, стратегіями, концепціями, доктринами, засадами, основами, деклараціями для ефективного розвитку Збройних Сил України.
Підходи до розроблення методики імплементації концептуальних документів стратегічного та оборонного планування можна уявити як поетапний процес:
- визначення концептуальних документів стратегічного і оборонного планування, які підлягають імплементації;
- визначення нормативно-правового акту оборонного планування (за рівнем ієрархії), який планується розробити;
- формування вимог концептуального документу до структури та змісту проєкту нормативно-правового акту;
- визначення способів імплементації концептуального документу у проєкті нормативно-правового акту;
- формування змістовної частини проєкту нормативно-правового акта та визначення відповідності нормативно-правового акта вимогам проєкту концептуального документу;
- управління ризиками та проведення моніторингу і контролю.
Обґрунтування функціональних вимог до програмної компоненти системи управління життєвим циклом автоматизованих систем у Збройних Силах України
Authors: Беляченко В. , Бобров С. , Закалад М. , Утюшев M. 
Published: May 2022

Актуальним документом щодо діяльності МОУ в сфері інформатизації є “Концепція галузевих програм створення ЄАСУ ЗСУ, єдиної інформаційної системи управління оборонними ресурсами …”, де визначено низку проблем, що потребують розв’язання:
- неузгодженість розробок, які не становлять єдиної системи;
- досягнення технічної та інформаційної сумісності;
- стан розпорошеності, при якому створені окремі компоненти інформаційної інфраструктури та інформаційних систем різняться між собою за часом створення, ступенем завершеності, масштабом розгортання та використаними технологіями, обсягом охоплених процесів та наповненням даними.
Розробки, які мали б бути підсистемами ЄАСУ ЗСУ, при механічному об`єднанні не створюють єдиної АСУ, а є об`єднанням АСУ які не здатні підтримувати цикли управління оборонними ресурсами, військами і зброєю у реальному часі у єдиному інформаційному просторі.
Розв’язання проблеми неузгодженості проєктної діяльності в сфері інформатизації органів військового управління Збройних Сил України пропонується шляхом створення системи управління життєвим циклом автоматизованих систем з робочою назвою АС “УЖЦ АСУ ЗСУ”.
Сформульовано базові функціональні вимоги до програмної компоненти АС “УЖЦ АСУ ЗСУ”, яка може бути використана для:
управління життєвим циклом програмного забезпечення на основі використання ALM-систем;
управління архітектурою організації – на основі EAM-систем;
управління сервісами організації на основі ESM-систем;
реалізації функції обміну даними з системами управління інформаційною інфраструктурою на основі процесів, описаних в ITIL.
Análise do abate de bovinos como componente de vigilância para a febre aftosa no estado do Maranhão, no ano de 2020
Authors: Prazeres Margarida Paula Carreira de Sá , Barros Rosiane de Jesus , Sousa Anna Karoline Amaral , Silva Iran Alves da , Fonseca Luciano Santos da , Coimbra Viviane Correa Silva 
Published: May 2022

Objetivou-se realizar a análise do abate de bovinos como componente de vigilância para a febre aftosa no estado do Maranhão, no ano de 2020. Para tanto, realizou-se um estudo epidemiológico descritivo utilizando dados secundários extraídos da: i) Guia de Trânsito Animal (GTA) para abate de bovinos emitidas no ano de 2020; ii) relação dos estabelecimentos de abate; e iii) relatório de cadastramento dos pontos de maior risco de disseminação de enfermidades. Dados adicionais sobre condenações de abate em estabelecimentos registrados no Serviço de Inspeção Federal (SIF), foram extraídos do site do Ministério da Agricultura Pecuária e Abastecimento (MAPA). Foram obtidos os seguintes indicadores de efetividade: i) distribuição dos estabelecimentos que abatem espécies suscetíveis à febre aftosa; ii) distribuição e concentração da origem dos animais; iii) percentual de animais e propriedades que enviaram animais suscetíveis à febre aftosa para abate; e iv) número de investigações com casos prováveis a partir dessa vigilância. Os resultados mostraram que foram emitidas 38.612 (97,488%) GTAs, com 37.642 (96,226%) bovinos. Destas movimentações 93,05% foram destinadas para dentro do estado (abate interno ao município de origem dos animais). A movimentação para abate teve participação de 9.015 (8,53%) das propriedades cadastradas. Conclui-se que a espécie bovina é, dentre as espécies suscetíveis à febre aftosa, aquela com maior destaque na finalidade de abate e para o abastecimento do mercado consumidor interno do Maranhão, sendo a região Oeste a de maior expressividade no número de emissões de GTA e quantitativo de bovinos para esta finalidade.
Perfil sociodemográfico e suporte social dos estudantes da área da saúde em tempos de pandemia
Authors: Silva Bruno de Andrade , Menezes Andreia Freire de , Abud Ana Cristina Freire , Farre Anny Giselly Milhome da Costa , Freitas Carlla Kalline Alves Cartaxo , Gois Cristiane Franca Lisboa , Diniz Fernanda Santos , Santos José Paulo dos Anjos , Jesus Vagner Santos de 
Published: May 2022

Objetivo: identificar o grau de satisfação com o suporte social entre os estudantes universitários da área de ciências da saúde do município de Sergipe através dos diferentes grupos. Método: Trata-se de uma pesquisa transversal, descritiva e exploratória. A amostra foi do tipo não probabilística, por conveniência, composta por 190 estudantes de ciências da saúde das Universidade Federais de Sergipe. Resultados: A satisfação com o suporte social foi considerada baixa por 57 (30%). O ambiente social no trabalho e a relação com os colegas da Universidade esteve associado positivamente com a satisfação sobre o suporte social. Estudantes que estão inseridos em uma família que conversa sobre sexo e sexualidade também apresentaram maior. Conclusão: A satisfação com o suporte social pode interferir diretamente nas condições de saúde física e mental dos estudantes, além de prejudicar o desempenho acadêmico e a vida social. O estudo do suporte social torna-se um grande aliado no planejamento de estratégias de suporte acadêmico e promoção da saúde mental nas universidades.
Os impactos da pandemia da Covid-19 na gestão financeira do setor de alimentação fora do Lar: Análise comparativa em um restaurante-pizzaria no município de Cacoal
Authors: Monthay Joyce Torezani , Candido Leticia Ferreira da Silva , Vidigal Filho Ademir Luiz , Magro Eleonice de Fátima Dal , Coelho Everton Galhoti , Andrade Liliane Maria Nery , Lovo Odirlei Arcangelo 
Published: May 2022

No início do ano de 2020 surgiu a pandemia da Covid-19, a qual afetou todos os segmentos da economia mundial. O setor de alimentação fora do lar foi um dos mais impactados econômica e financeiramente, devido as restrições e distanciamento social . Frente a isso, o objetivo desta pesquisa é analisar os impactos da pandemia da Covid-19 na gestão econômico-financeira de um restaurante-pizzaria no município de Cacoal. O estudo possui abordagem quali-quantitativa, de natureza exploratória. Através da análise comparativa dos indicadores entre os exercícios de 2016 e 2020, verificou-se que a pandemia refletiu nos relatórios financeiros com redução considerável da receita líquida de vendas no ano de 2020 em comparativo aos anos anteriores. Apesar dessa redução, a empresa aponta a capacidade de cumprir seus compromissos, mas tem utilizado fonte de capital de terceiros para maximizar liquidez. A empresa ainda demonstra preocupações e medidas para que impactos da pandemia não afetem diretamente seus desempenhos financeiros e operacionais.
The Relationship Between Cancer and Functional and Structural Markers of Subclinical Atherosclerosis: A Systematic Review and Meta-Analysis
Authors: Diao Yuhong , Liu Zhixing , Chen Li , Zhang Weiping , Sun Dandan 
Published: May 2022

ObjectivesThe relationship between cancer and subclinical atherosclerosis has always been the focus of people's attention. We conducted a systematic review and meta-analysis by evaluating the effects of cancer on functional and structural markers of subclinical atherosclerosis:intima-media thickness (IMT), pulse wave velocity (PWV), and flow-mediated vasodilation (FMD).MethodsA comprehensive and systematic literature search was conducted on the internet. Sensitivity analysis, publication bias, standard mean difference (SMD), corresponding 95% confidence interval (95% CI), and subgroup analysis were performed for all relevant research indicators in the retrieved literature.ResultsForty-six studies were included, including 3,729 cancer patients and 2,404 healthy controls. Cancer patients had significantly thicker IMT [SMD (95%CI) = 0.290 (0.069 to 0.511), P = 0.010] and higher PWV [SMD (95%CI) = 0.392 (0.136 to 0.647), P = 0.003] compared with healthy controls. There was no significant difference in FMD [SMD (95% CI) = −0.192 (−0.527 to 0.144), P &gt; 0.05). After subgrouping by age, male proportion, and treatment, the analysis results of IMT ≥ 50 years old, PWV and FMD &lt; 50 years old, male proportion ≥50%, chemotherapy group, IMT and PWV radiotherapy group, and PWV endocrine therapy group were statistically significant (P &lt; 0.05). There were no significant differences in other subgroup analyses, overall sensitivity analysis, and publication bias (p &lt; 0.05).ConclusionsCancer may promote subclinical atherosclerosis, and change the functional and structural markers of subclinical atherosclerosis such as IMT and PWV. Early intervention and prevention should be pursued.
In Vitro Estimation of Tracheobronchial and Alveolar Doses Using Filters
Authors: Finlay Warren H. , Farina Dino J. , Tavernini Scott , Martin Andrew R. 
Published: May 2022

To date, in vitro estimation of doses delivered by an inhaler to the different major regions of the lung has required combining particle size measurements of the inhaled aerosol with in silico deposition models. Such a two step process is labor and time intensive. Here, we describe instead the development of an apparatus that allows direct estimation of regional lung deposition by measurement of doses collected on purpose-built metal grid filters that mimic tracheobronchial deposition efficiency. Placing these filters downstream of the Alberta Idealized Throat and upstream of a final filter allows collection of doses depositing in the extrathoracic, tracheobronchial and alveolar regions. Artificial electrostatic deposition on the metal tracheobronchial filters is prevented by a custom inline electrostatic neutralizer. We use the resulting apparatus to estimate regional deposition with a variety of dry powder inhalers during realistic, time-varying inhalation maneuvers and three pMDIs with a constant flow rate of 30 l/min. These results are compared to those obtained with the traditional two step approach that combines cascade impaction with a regional deposition model. Good agreement is found between the two approaches, indicating that the present direct method may be an efficient, time-saving alternative method for in vitro estimation of regional lung doses.
A Population-Level Analysis of the Protective Effects of Androgen Deprivation Therapy Against COVID-19 Disease Incidence and Severity
Authors: Lee Kyung Min , Heberer Kent , Gao Anthony , Becker Daniel J. , Loeb Stacy , Makarov Danil V. , Gulanski Barbara , DuVall Scott L. , Aslan Mihaela , Lee Jennifer , Shih Mei-Chiung , Lynch Julie A. , Hauger Richard L. , Rettig Matthew 
Published: May 2022

BackgroundThe incidence and severity of coronavirus disease 19 (COVID-19) is substantially higher in men. Sex hormones may be a potential mechanism for differences in COVID-19 outcome in men and women. We hypothesized that men treated with androgen deprivation therapy (ADT) have lower incidence and severity of COVID-19.MethodsWe conducted an observational study of male Veterans treated in the Veterans Health Administration from February 15th to July 15th, 2020. We developed a propensity score model to predict the likelihood to undergo Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) testing. We performed multivariable logistic regression modeling adjusted with inverse probability weighting to examine the relationship between ADT and COVID-19 incidence. We conducted logistic regression analysis among COVID-19 patients to test the association between ADT and COVID-19 severity.ResultsWe identified a large cohort of 246,087 VA male patients who had been tested for SARS-CoV-2, of whom 3,057 men were exposed to ADT, and 36,096 men with cancer without ADT. Of these, 295 ADT patients and 2,427 cancer patients not on ADT had severe COVID-19 illness. In the primary, propensity-weighted comparison of ADT patients to cancer patients not on ADT, ADT was associated with decreased likelihood of testing positive for SARS-CoV-2 (adjusted OR, 0.88 [95% CI, 0.81–0.95]; p = 0.001). Furthermore, ADT was associated with fewer severe COVID-19 outcomes (OR 0.72 [95% CI 0.53–0.96]; p = 0.03).ConclusionADT is associated with reduced incidence and severity of COVID-19 amongst male Veterans. Testosterone and androgen receptor signaling may confer increased risk for SARS-CoV-2 infection and contribute to severe COVID-19 pathophysiology in men.
Contrasting Association Between COVID-19 Vaccine Hesitancy and Mental Health Status in India and Saudi Arabia—A Preliminary Evidence Collected During the Second Wave of COVID-19 Pandemic
Authors: Jayakumar Saikarthik , Ilango Saraswathi , Kumar K. Senthil , Alassaf Abdullah , Aljabr Abdullah , Paramasivam Anand , Mickeymaray Suresh , Hawsah Yazeed Mohammed , Aldawish Ahmed Saad 
Published: May 2022

BackgroundVaccine hesitancy is a global public health threat. Understanding the role of psychological factors in vaccine hesitancy is often neglected and relatively less explored.Aim and ObjectivesTo analyze the relationship between mental health and COVID-19 vaccine hesitancy before and after the advent of COVID-19 vaccines (AC19V) in the general population of India and Saudi Arabia (KSA) which vary in severity of the pandemic and vaccine mandates.Materials and MethodsA total of 677 adult participants from India and KSA participated in this cross-sectional online web-based survey. Sociodemographic details and current COVID-19 status pertaining to infection and vaccination were collected. Depression, anxiety, post-traumatic stress disorder (PTSD) symptoms, and perceptive need for mental health support (MHS) were assessed before and after AC19V. A newly constructed and validated COVID19 vaccine hesitancy scale-12 (COVID19-VHS12) scale was used to evaluate the COVID-19 vaccine hesitancy.ResultsPrevalence and levels of depression and anxiety symptoms decreased significantly in Saudis but not in Indians after AC19V. PTSD symptoms showed a significant reduction in both India and KSA. Anxiety symptoms were higher in KSA than India before AC19V while PTSD was higher in India before and after AC19V. Except for the place of residence and employment status, the subgroups of sociodemographic variables which were at higher risk of negative mental health before AC19V showed improvement in their mental health after AC19V. The prevalence of COVID-19 vaccine hesitancy in India and KSA was 50.8% (95% CI 45.73–55.89%) and 55.7% (95% CI 50.16–61.31%), respectively. A bidirectional association between vaccine hesitancy and mental health was observed in KSA but not in India. Higher vaccine hesitancy favored higher levels of depression, anxiety, and perceptive need for MHS and vice versa in KSA. None of the mental health parameters predicted vaccine hesitancy in India, while higher vaccine hesitancy increased the risk of anxiety.ConclusionVaccine hesitancy has a negative impact on mental health and vice versa over and above the impact of sociodemographic factors and COVID-19 vaccination and infection status which shows variations between India and KSA.
High Dose Vitamin D3 Supplementation Is Not Associated With Lower Mortality in Critically Ill Patients: A Meta-Analysis of Randomized Control Trials
Authors: Gao Zhiwei , Xie Jianfeng , Li Cong , Liu Ling , Yang Yi 
Published: May 2022

BackgroundVitamin D deficiency is a common condition in critically ill patients. A high dose of vitamin D3 can rapidly restore vitamin D levels. The aim of this meta-analysis was to synthesize the results from up-to-date randomized control trials (RCT) and validate the effect of vitamin D3 in critically ill patients.Study MethodsSeveral databases, including PubMed, Web of Science, EMBASE, and the Cochrane Central database, were searched up to December 4th, 2020. All RCTs that investigated the use of a high dose of vitamin D3 in critically ill patients and reported mortality data were included in the meta-analysis. The primary outcome was the mortality truncated to day 28 and day 90.ResultsA total of 10 RCTs enrolling 2058 patients were finally included. The use of a high dose of vitamin D3 in critically ill patients could not decrease the mortality truncated to day 28 (RR 0.93, 95% CI 0.78–1.11, P = 0.43) or day 90 (RR 0.91, 95% CI 0.79–1.05, P = 0.21). A high dose of vitamin D3 could significantly reduce the ventilator days (MD −9.38, 95%CI −13.44 to −5.31, P &lt; 0.001), but there were no statistic difference in length of ICU stay (MD −2.76, 95% CI −6.27 to 0.74, P = 0.12) and hospital stay (MD −2.42, 95% CI −6.21 to 1.36, P = 0.21). No significant difference was observed in adverse events between the vitamin D3 group and the placebo group.ConclusionThe use of high dose vitamin D3 was not associated with decreased mortality in critically ill patients, but could significantly reduce the ventilator days.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42020179195.
Construction and Verification of Immunohistochemistry Parameters-Based Classifier to Predict Local-Recurrence of Upper Tract Urothelial Carcinoma After Kidney-Sparing Surgery
Authors: Cheng Xu , Liu Wentao , Li Yijian , Wang Yinhuai 
Published: May 2022

BackgroundKidney-sparing surgery (KSS) for upper tract urothelial carcinomas (UTUCs) has been gradually performed in selected patients beyond the recommendation of guidelines. However, there is still a lack of tools to evaluate postoperative local recurrence. Herein, a new nomogram was established to predict the local recurrence risk after KSS.MethodsPatients were randomly divided into two cohorts (training: testing cohorts = 7:3). Cancer samples after KSS were used for immunohistochemical tests to detect molecules missing in previous pathology reports. Then, the total number of molecules were screened by the least absolute shrinkage and selection operator (LASSO) method to construct an IHCscore, which was further tested in the validation cohort. Finally, the IHCscore and other clinicopathologic parameters were combined to develop a more accurate model using univariate and multivariate Cox regression methods.ResultsIn total, 200 patients were included. The Kaplan–Meier test showed that high Ki-67 and loss of Uroplakin III and E-cadherin were correlated with poor recurrence-free survival. The individual IHCscore was calculated based on the expression levels of Ki-67, Her2 and E-cadherin. Based on the IHC score, patients were further classified as low- or high-risk, and a significant difference in the recurrence-free survival was observed between the two groups. Then, the nomogram was developed based on Gender, surgical margin and IHCscore; this nomogram had a higher AUC (0.847) in predicting 3-year recurrence-free survival than the IHCscore alone (0.788).ConclusionsThis easy-to-use nomogram shows better prediction accuracy in recurrence-free survival after KSS and may guide individualized intravesical chemotherapy. However, a larger sample is required for external validation.
Charts and LMS Tables of Transfontanellar and Transvertical Ear-to-Ear Distances for Gestational Age
Authors: Arnold Nancy , Ascherl Rudolf Georg , Thome Ulrich Herbert 
Published: May 2022

IntroductionTo date cranial development has only been described by analyzing occipitofrontal circumference (OFC). More precise methods of determining head measurements have not been widely adopted. The use of additional measurements has the potential to better account for the three-dimensional structure of the head. Our aim was to put forward centile curves of such measurements for gestational age along with a compound head volume index.MethodsWe created generalized additive models for location, scale, and shape of two ear-to-ear distances (EED), transfontanellar (fEED) and transvertical (vEED), from birth anthropometric data. Same was done for OFC, crown-heel length, and birth weight to allow for comparison of our models with growth charts by Voigt et al. and Fenton and Kim.ResultsGrowth charts and tables of LMS parameters for fEED and vEED were derived from 6,610 patients admitted to our NICU and 625 healthy term newborns. With increasing gestational age EEDs increase about half as fast compared to OFC in absolute terms, their relative growths are fairly similar.DiscussionDifferences to the charts by Fenton and Kim are minute. Tape measurements, such as fEED or vEED can be added to routine anthropometry at little extra costs. These charts may be helpful for following and evaluating head sizes and growth of preterm and term infants in three dimensions.