bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic implications of galectin-3 in patients with atrial fibrillation
Authors: Lee Kwang-No , Kim Do Young , Boo Ki Yung , Kim Yun Gi , Roh Seung-Young , Baek Yong-Soo , Kim Dong-Hyeok , Lee Dae In , Shim Jaemin , Choi Jong-Il , Hwang Gyo-Seung , Kim Young-Hoon 
Published: January 2022

AbstractAtrial fibrosis can present as an arrhythmogenic substrate that is correlated with higher recurrence after catheter ablation for atrial fibrillation. Galectin-3, a beta-galactoside-binding lectin, is highly expressed and secreted from macrophages and is important in inflammation and fibrosis. We assessed the clinical implications of serum galectin-3 in patients with atrial fibrillation. This was a prospective cohort study of consecutive patients who underwent radiofrequency catheter ablation in a tertiary referral center from February 2017 to September 2017. Intracardiac blood sampling, echocardiographic measurements, magnetic resonance imaging with late gadolinium enhancement, electrophysiologic testing, and endocardial voltage mapping were consistently implemented in 75 patients before the ablation. Serum galectin-3 level was higher in patients with diabetes mellitus and was correlated with values that indicated the left atrial size. During a median 14 months of follow-up, atrial tachyarrhythmia recurred in 27% of patients. In multivariable Cox regression analysis, non-paroxysmal atrial fibrillation (hazard ratio 6.8; 95% confidence interval 1.6–28.9) and higher galectin-3 levels (hazard ratio 1.3; 95% confidence interval 1.0–1.7) were associated with increased risk of recurrence. Serum galectin-3 may be a prognostic biomarker for risk stratification in patients with atrial fibrillation planned catheter ablation.
Influential groups for seeding and sustaining nonlinear contagion in heterogeneous hypergraphs
Authors: St-Onge Guillaume , Iacopini Iacopo , Latora Vito , Barrat Alain , Petri Giovanni , Allard Antoine , Hébert-Dufresne Laurent 
Published: January 2022

AbstractContagion phenomena are often the results of multibody interactions—such as superspreading events or social reinforcement—describable as hypergraphs. We develop an approximate master equation framework to study contagions on hypergraphs with a heterogeneous structure in terms of group size (hyperedge cardinality) and of node membership (hyperdegree). By mapping multibody interactions to nonlinear infection rates, we demonstrate the influence of large groups in two ways. First, we characterize the phase transition, which can be continuous or discontinuous with a bistable regime. Our analytical expressions for the critical and tricritical points highlight the influence of the first three moments of the membership distribution. We also show that heterogeneous group sizes and nonlinear contagion promote a mesoscopic localization regime where contagion is sustained by the largest groups, thereby inhibiting bistability. Second, we formulate an optimal seeding problem for hypergraph contagion and compare two strategies: allocating seeds according to node or group properties. We find that, when the contagion is sufficiently nonlinear, groups are more effective seeds than individual hubs.
Heteroepitaxial growth and interface band alignment in a large-mismatch CsPbI3/GaN heterojunction
Authors: Liu Xueyin , Cao Dan , Yao Yizhou , Tang Pengtao , Zhang Mingsong , Chen Xiaoshuang , Shu Haibo 
Published: January 2022

Heteroepitaxial growth of single-crystal CsPbI3 nanoplatelets on GaN substrate leads to the formation of a type-II CsPbI3/GaN heterojunction that significantly enhances the separation and extraction of free carriers inside CsPbI3.
Identification of potential immunotherapy biomarkers for breast cancer by bioinformatics analysis
Authors: Song Yao , Lu Meiling , Feng Lijin , Chen Qian , Huang Hua , Lin Qing 
Published: January 2022

Abstract
Breast cancer is a serious malignancy with a high incidence worldwide and a tendency to relapse. We used integrated bioinformatics analysis to identify potential biomarkers in breast carcinoma in the present study. Microarray data, 127breast tumor samples and 23 non-tumor samples, received from the Gene Expression Omnibus (GEO) dataset; 121 differentially expressed genes (DEGs) were selected. Functional analysis using DAVID revealed that these DEGs were highly gathered in endodermal cell differentiation and proteinaceous extracellular matrix. Five bioactive compounds (prostaglandin J2, tanespimycin, semustine, 5182598, and flunarizine) were identified using Connectivity Map. We used Cytoscape software and STRING dataset to structure a protein–protein interaction (PPI) network. The expression of CD24, MMP1, SDC1, and SPP1 was much higher in breast carcinoma tissue than in Para cancerous tissues analyzed by Gene Expression Profiling Interactive Analysis (GEPIA) and ONCOMINE. Overexpression ofCD24, MMP1, SDC1, and SPP1 indicated the poor prognosis in breast carcinoma patients analyzed by Kaplan–Meier (KM) Plotter. Immunohistochemistry microarray was used to further confirm that protein expression of CD24, MMP1, SDC1, and SPP1 was much higher in tumor sections than in Para cancerous tissues. Hub genes expression at the protein level was correlated tothe breast cancer subtype and grade. Furthermore, immunity analysis showed that CD24, MMP1, SDC1, and SPP1 were potentially associated with five immune cell types infiltration (CD8+ T cells, CD4+ T cells, neutrophils, macrophages,and dendritic cells) by TIMER. Thus, this study indicates potential biomarkers that could have applications in the development of immune therapy for breast cancer. However, further studies are required for verifying these results in vivo and vitro.
A graph convolutional neural network model with Fisher vector encoding and channel‐wise spatial‐temporal aggregation for skeleton‐based action recognition
Authors: Tang Jun , Wang Yanjiang , Fu Sichao , Liu Baodi , Liu Weifeng 
Published: January 2022

AbstractSkeleton‐based action recognition is an inspired yet challenging task in computer vision. Recently, the latest graph convolutional network (GCN), which generalises well‐established convolutional neural networks to non‐Euclidean structures, is proven to be highly successful for action recognition from body skeleton data. However, the GCN architecture has not been fully studied. In this work, a Fisher vector (FV) encoding based GCN architecture (FV‐GCN) is proposed, which exceeds the limitations of existing GCN‐based methods by combining the GCN model with FV encoding. A channel‐wise spatial–temporal aggregation function to preserve spatial–temporal information in the whole action clip and integrate it into the FV‐GCN architecture is also presented. Since FV is different from the GCN structure, this hybrid architecture that incorporates the advantages of both algorithms can discover complementary information of feature representation effectively. On two challenging human action datasets, kinetics, and NTU‐RGBD, improved performance is demonstrated over the baseline method, and the FV‐GCN is better or comparable to some state‐of‐the‐art methods.
Compact triple‐broadband implantable antenna for multi‐functions in telemedicine
Authors: Fan Yi , Li ZhongXin , Liu XiongYing , Li XinNing , Xu Cao , Yang HongCai 
Published: January 2022

AbstractA compact implantable antenna is designed to operate in the Medical Implant Communication Services (MICS; 402–405 MHz) band, 915‐MHz Industrial, Scientific, and Medical (ISM; 902–928 MHz) band, and 2.4‐GHz ISM (2.4–2.48 GHz) band; via the triple bands, the multi functions, such as biomedical data transferring, wireless energy supply, and control signal sending, can be implemented. By embedding symmetric slots in the radiation patch and introducing a shorting pin, multiple resonances are generated with −10‐dB simulated bandwidths of 76 MHz (369–445 MHz) at the MICS band, 45 MHz (891–936 MHz) at the 915‐MHz ISM band, and 1025 MHz (1930–2955 MHz) at the 2.45‐GHz ISM band. In addition, compact dimensions of 11.6 × 11.6 × 1.27 mm (170.89 mm3) are obtained with the simulated peak gains of −41.3 dBi, −23.5 dBi, and −28.7 dBi in the triple bands. To improve impedance matching of the proposed antenna in the upper band, two symmetric U‐shaped slots are etched in the ground. The fabricated antenna was tested in fresh pork, and the measured results agree well with those simulated in the phantom. Advantages of compact size and broad triple bands make the proposed antenna great potential for telemedicine applications.
Account of the baryonic feedback effect in γ-ray measurements of intergalactic magnetic fields
Authors: Bondarenko K. , Boyarsky A. , Korochkin A. , Neronov A. , Semikoz D. , Sokolenko A. 
Published: January 2022

Aims. Intergalactic magnetic fields in the voids of the large-scale structure can be probed via measurements of secondary γ-ray emission from γ-ray interactions with extragalactic background light. Lower bounds on the magnetic field in the voids were derived from the nondetection of this emission. It is not clear a priori what kind of magnetic field is responsible for the suppression of the secondary γ-ray flux: a cosmological magnetic field that might be filling the voids, or the field spread by galactic winds driven by star formation and active galactic nuclei.
Methods. We used IllustrisTNG cosmological simulations to study the effect of magnetized galactic wind bubbles on the secondary γ-ray flux.
Results. We show that within the IllustrisTNG model of baryonic feedback, galactic wind bubbles typically provide energy-independent secondary flux suppression at a level of about 10%. The observed flux suppression effect has to be due to the cosmological magnetic field in the voids. This might not be the case for the special case when the primary γ-ray source has a hard intrinsic γ-ray spectrum that peaks in the energy range above 50 TeV. In this case, the observational data may be strongly affected by the magnetized bubble that is blown by the source host galaxy.
A candidate short-period sub-Earth orbiting Proxima Centauri
Authors: Faria J. P. , Suárez Mascareño A. , Figueira P. , Silva A. M. , Damasso M. , Demangeon O. , Pepe F. , Santos N. C. , Rebolo R. , Cristiani S. , Adibekyan V. , Alibert Y. , Allart R. , Barros S. C. C. , Cabral A. , D’Odorico V. , Di Marcantonio P. , Dumusque X. , Ehrenreich D. , González Hernández J. I. , Hara N. , Lillo-Box J. , Lo Curto G. , Lovis C. , Martins C. J. A. P. , Mégevand D. , Mehner A. , Micela G. , Molaro P. , Nunes N. J. , Pallé E. , Poretti E. , Sousa S. G. , Sozzetti A. , Tabernero H. , Udry S. , Zapatero Osorio M. R. 
Published: January 2022

Context. Proxima Centauri is the closest star to the Sun. This small, low-mass, mid M dwarf is known to host an Earth-mass exoplanet with an orbital period of 11.2 days within the habitable zone, as well as a long-period planet candidate with an orbital period of close to 5 yr.
Aims. We report on the analysis of a large set of observations taken with the ESPRESSO spectrograph at the VLT aimed at a thorough evaluation of the presence of a third low-mass planetary companion, which started emerging during a previous campaign.
Methods. Radial velocities (RVs) were calculated using both a cross-correlation function (CCF) and a template matching approach. The RV analysis includes a component to model Proxima’s activity using a Gaussian process (GP). We use the CCF’s full width at half maximum to help constrain the GP, and we study other simultaneous observables as activity indicators in order to assess the nature of any potential RV signals.
Results. We detect a signal at 5.12 ± 0.04 days with a semi-amplitude of 39 ± 7 cm s−1. The analysis of subsets of the ESPRESSO data, the activity indicators, and chromatic RVs suggest that this signal is not caused by stellar variability but instead by a planetary companion with a minimum mass of 0.26 ± 0.05 M⊕ (about twice the mass of Mars) orbiting at 0.029 au from the star. The orbital eccentricity is well constrained and compatible with a circular orbit.
Electronic and nonlinear optical properties of doped/undoped graphene via coronene based models: a DFT study
Authors: El Masfioui M. , Bahsine S. , Elbiyaali A. , Allali F. 
Published: January 2022

Coronene C24H12 can be considered as graphene nanoflakes. This aromatic hydrocarbon allows for detailed calculations and the rapid evaluation of a variety of doped structures while maintaining the periodic aromaticity of graphene. In this study, through density functional theory (DFT) at the B3LYP (BECKE 3-PARAMETER LEE-YANG-PARR) functional with a 6-31G (d) basis set, we have investigated the effects of substituting carbon atoms with B, N, and O on the electronic structure, linear and nonlinear optical properties of graphene.
Therefore, we found that the bandgap varies as a function of the considered structure.
CONCERTO at APEX: Installation and first phase of on-sky commissioning
Authors: Catalano A. , Ade P. , Aravena M. , Barria E. , Beelen A. , Benoit A. , Béthermin M. , Bounmy J. , Bourrion O. , Bres G. , De Breuck C. , Calvo M. , Désert F.-X. , Durán C.A , Duvauchelle G. , Eraud L. , Fasano A. , Fenouillet T. , Garcia J. , Garde G. , Goupy J. , Groppi C. , Hoarau C. , Hu W. , Lagache G. , Lambert J.-C. , Leggeri J.-P. , Levy-Bertrand F. , Macías-Pérez J. , Mani H. , Marpaud J. , Marton M. , Mauskopf P. , Monfardini A. , Pisano G. , Ponthieu N. , Prieur L. , Raffin G. , Roni S. , Roudier S. , Tourres D. , Tucker C. , Vivargent L. 
Published: January 2022

CONCERTO (CarbON CII line in post-rEionisation and ReionisaTiOn) is a large field-of-view (FoV) spectro-imager that has been installed on the Cassegrain Cabin of Atacama Pathfinder EXperiment (APEX) telescope in April 2021. CONCERTO hosts 2 focal planes and a total number of 4000 Kinetic Inductance Detectors (KID), with an instantaneous FoV of 18.6 arcminutes in the range of 130-310 GHz. The spectral resolution can be easily tuned down to 1 GHz depending on the scientific target. The scientific program of CONCERTO has many objectives, with two main programs focused on mapping the fluctuations of the [CII] line intensity in the reionisation and postreionisation epoch (4.5<z<8.5), and on studying galaxy clusters via the thermal and kinetic Sunyaev-Zel’dovich (SZ) effect. CONCERTO will also measure the dust and molecular gas contents of local and intermediate-redshift galaxies, it will study the Galactic star-forming clouds and finally it will observe the CO intensity fluctuations arising from 0.3<z<2 galaxies.
The design of the instrument, installation at APEX and current status of the commissioning phase and science verification will be presented. Also we describe the deployment and first on-sky tests performed between April and June 2021.
Sunyaev Zel’dovich high resolution view of filamentary structures between galaxy clusters pairs
Authors: Radiconi Federico ,   for the ACT collaboration
Published: January 2022

Strong observational and theoretical evidences suggest that about half of the baryons in the Universe should lie outside galaxy clusters in a lowdensity and hot phase in filaments connecting galaxy clusters. Due to the low density, most of this filamentary plasma can not be detected by X-ray observatories. In particular cases of low redshift cluster pairs in the pre-merging phase, the Sunyaev Zel’dovich (SZ) effect can be used to observe the intercluster regions and detect the imprint of missing baryons.
The Abell 399-401 (A399-401) system is the perfect laboratory to test our ability to detect filamentary structures via the SZ effect with <~ 1′ angular resolution. This pair has been well studied at several frequencies: it exhibits double radio-halos, an excess of X-ray emission in the intercluster region and a synchrotron radio ‘ridge’ connecting the two clusters. Moreover the Planck satellite provided the first SZ detection of the gas between A399-401 despite the poor angular resolution (~ 10′) of its SZ map.
We have used an Atacama Cosmology Telescope (ACT) and Planck satellite Compton-y map (1:65′ angular resolution) that combines ACT data from 2008 to 2019 with Planck maps to study the A399-401 system in detail. We present the data analysis and results.
Performance analysis of an M/G/1 queue with bi-level randomized (p, N1, N2)-policy
Authors: Kuang Xinyu , Tang Yinghui , Yu Miaomiao , Wu Wenqing 
Published: January 2022

This paper proposes an M/G/1 queueing model with bi-level randomized (p, N1, N2)-policy. That is, after all of the customers in the system are served, the server is closed down immediately. If N1(≥ 1) customers are accumulated in the queue, the server is activated for service with probability p(0 ≤ p ≤ 1) or still left off with probability 1 − p. When the number of customers in the system becomes N2(≥ N1), the server begins serving the waiting customers until the system becomes empty again. Using the total probability decomposition technique and the Laplace transform, we study the transient queue length distribution and obtain the expressions of the Laplace transform of the transient queue-length distribution with respect to time t. Then, employing L’Hospital’s rule and some algebraic operations, the explicit recursive formulas of the steady-state queue-length distribution, which can be used to accurately evaluate the probabilities of queue length, are presented. Moreover, some other important queuing performance indices, such as the explicit expressions of its probability generating function of the steady-state queue-length distribution, the expected queue size and so on, are derived. Meanwhile, we investigate the system capacity optimization design by the steady-state queue-length distribution. Finally, an operating cost function is constructed, and by numerical calculation, we find the minimum of the long-run average cost rate and the optimal bi-level threshold policy
(N*1,N*2)

that satisfies the average waiting time constraints.
Incidence and Outcomes Associated with 6,841 Isolated Distal Deep Vein Thromboses in Patients with 13 Common Cancers
Authors: Mahajan Anjlee , Brunson Ann , Eldredge Joanna , White Richard H. , Keegan Theresa H. M. , Wun Ted 
Published: January 2022

Abstract
Introduction The epidemiology of isolated distal deep venous thrombosis (iDDVT) among cancer patients is not well described, particularly the incidence of recurrent venous thromboembolism (rVTE) and effect on mortality by cancer type.
Methods The cumulative incidence (CI) of iDDVT was determined for patients with 13 common cancers between 2005 and 2017 using the California Cancer Registry linked to the California Patient Discharge and Emergency Department Utilization datasets. The CI of rVTE was calculated and association of incident cancer-associated thrombosis (CT) location with rVTE was determined using Cox proportional hazards regression models. The association of incident CT location with overall and cancer-specific mortality was determined using Cox models, stratified by cancer site, and adjusted for individual characteristics.
Results Among 942,109 cancer patients, CT occurred in 62,003 (6.6%): of these, 6,841 (11.0%) were iDDVT. Compared with more proximal sites of CT, iDDVT was associated with similar risk for rVTE. IDDVT was associated with increased mortality across all cancer types when compared with patients without CT (hazard ratio: 1.56–4.60). The effect of iDDVT on mortality was similar to that of proximal DVT (pDVT) for most cancers except lung, colorectal, bladder, uterine, brain, and myeloma, where iDDVT was associated with a lesser association with mortality.
Conclusion iDDVT represented 11% of CT. The risk of rVTE after iDDVT was similar to other sites of CT and rVTE occurred in more proximal locations after an incident iDDVT. IDDVT was associated with increased mortality and this effect was similar to that of pulmonary embolism or pDVT for most cancer types.
δ-Keto Aminoacrylonitriles and δ-Keto Aminoenones from 1-Pyrrolines, Cyanoacetylenes, and Acetylenic Ketones
Authors: Trofimov Boris A. , Oparina Ludmila A. , Mal’kina Anastasiya G. , Kolyvanov Nikita A. , Ushakov Igor A. , Saliy Ivan V. , Apartsin Konstantin A. 
Published: January 2022

AbstractThe ring-opening/functionalization of 1-pyrrolines by cyano­acetylenes or acetylenic ketones (20–80 °C, MeCN, H2O) affords δ-keto aminoacrylonitriles and δ-keto aminoenones, mostly as the Z-isomers, in up to 85% yields. The synthesis involves C(2)–N bond cleavage in the intermediate hemiaminal resulting from the intermediate 1,3(4)-dipolar 1-pyrroline/acetylene complexes and water.
Synthesis of Dibenzotetrathiafulvalenes of Oxalic Acid with Electron-Rich Aromatic 1,2-Dithiols and Application to Dithioacetalization with 9-Fluorenecarboxylic Acids or Dicarboxylic Acids
Authors: Sakai Norio , Minato Kohei , Nakata Shota , Ogiwara Yohei 
Published: January 2022

AbstractWe have developed a two-step synthesis of dibenzotetrathiafulvalene (DBTTF) derivatives by combining the indium-catalyzed reductive dithioacetalization of oxalic acid and electron-rich aromatic dithiols with a subsequent oxidation of the resultant dithioacetals. The same transformation of electron-rich aromatic dithiols with either 9-fluorenecarboxylic acid derivatives or dicarboxylic acids effectively produced the corresponding benzo-1,3-dithiafulvene derivatives.
Acute Severe Colitis: The Need for Joint Management between Gastroenterologists and Surgeons
Authors: Fleshner Phillip , Melmed Gil Y. 
Published: January 2022

AbstractThe management of hospitalized patients with acute, severe ulcerative colitis involves close coordination among a multidisciplinary team. For patients not improving on intravenous corticosteroids, surgical consultation should be sought. The remaining hospital course requires frequent communications between the gastroenterologist managing the medical aspects of care, and the colorectal surgeon involved in planning for potential surgery, to optimize patient outcomes. This comanagement includes joint decision-making around the timing of surgery, minimizing medications associated with postoperative morbidity, addressing nutritional and psychosocial aspects of the patient's condition, and planning for a coordinated postoperative course. In this review, we highlight these aspects of care and the need for coordination and communication between gastroenterologists and surgeons in the management of acute severe colitis.
A Multi-Disciplinary Approach to Perianal Fistulizing Crohn's Disease
Authors: Wiseman Jacob , Chawla Tanya , Morin Frederic , de Buck van Overstraeten Anthony , Weizman Adam V. 
Published: January 2022

AbstractPerianal fistulizing Crohn's disease represents a severe phenotype associated with significant morbidity. Patients with perianal fistulizing disease are more likely to have a severe disease course and have significant reductions in quality of life. Moreover, these patients are at risk for the development of distal rectal and anal cancers. Given the complexity and severity of this patient group, the management of perianal Crohn's disease must be undertaken by a multidisciplinary team. The gastroenterologist and colorectal surgeon play a critical role in the diagnosis and management of perianal fistulizing disease. An examination under anesthesia provides critical information and is an essential part of the work-up of complex perianal fistulas. The radiologist also plays a central role in characterizing anatomy and assessing response to treatment. Several imaging modalities are available for these patients with magnetic resonance imaging as the imaging modality of choice. Perianal disease developing after ileal pouch-anal anastomosis represents a particularly challenging form of fistulizing disease and requires a multidisciplinary clinical and radiologic approach to differentiate surgical complications from recurrent Crohn's disease.