bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percutaneous Transsplenic Balloon-Assisted Transjugular Intrahepatic Portosystemic Shunt Placement in Patients with Portal Vein Obliteration for Portal Vein Recanalization: Feasibility, Safety and Effectiveness
Authors: Meine T. C. , Becker L. S. , Dewald C. L. A. , Maschke S. K. , Maasoumy B. , Jaeckel E. , Wedemeyer H. , Wacker F. K. , Meyer B. C. , Hinrichs J. B. 
Published: January 2022

Abstract
Purpose
To assess the feasibility, safety and effectiveness of portal vein recanalization (PVR)–transjugular portosystemic shunt (TIPS) placement via splenic access using a balloon puncture technique.

Materials and Methods
In a single-center retrospective study from March 2017 to February 2021, 14 consecutive patients with portal hypertension, chronic liver disease and portal vein occlusion or near-complete (> 95%) occlusion were referred for PVR–TIPS placement. Feasibility, safety and effectiveness including procedural characteristics such as technical success, complication profile and splenic access time (SAT), balloon positioning time (BPT), conventional portal vein entry time (CPVET), overall procedure time (OPT), fluoroscopy time (FT), dose–area product (DAP) and air kerma (AK) were evaluated.

Results
Transsplenic PVR–TIPS using balloon puncture technique was technically feasible in 12 of 14 patients (8 men, 49 ± 13 years). In two patients without detectable intrahepatic portal vein branches, TIPS placement was not feasible and both patients were referred for further treatment with nonselective beta blockers and endoscopic variceal ligation. No complications grade > 3 of the Cardiovascular and Interventional Radiological Society of Europe classification system occurred. The SAT was 25 ± 21 min, CPVET was 33 ± 26 min, the OPT was 158 ± 54 min, the FT was 42 ± 22 min, the DAP was 167.84 ± 129.23 Gy*cm2 and the AK was 1150.70 ± 910.73 mGy.

Conclusions
Transsplenic PVR–TIPS using a balloon puncture technique is feasible and appears to be safe in our series of patients with obliteration of the portal vein. It expands the interventional options in patients with chronic PVT.
Infant urinary metabolomic profile in a fatal acute methadone intoxication
Authors: Chighine Alberto , Porcu Michele , Ferino Giulio , Lenigno Nicola , Trignano Claudia , d’Aloja Ernesto , Locci Emanuela 
Published: January 2022

AbstractA case report suspicious for a Sudden Infant Death Syndrome is here described. Pathological findings were consistent with an acute respiratory failure while toxicological analysis revealed an elevated blood methadone concentration. Death was then ascribed to an acute methadone intoxication. In addition to the routinary approach, the urinary sample collected at autopsy was investigated with a 1H NMR metabolomic approach and the identified metabolomic profile was challenged with the urinary metabolomic profiles previously obtained from 10 newborns who experienced perinatal asphyxia and 16 healthy control newborns. Intriguingly, the urinary profile of the methadone intoxicated infant was very similar to those belonging to the perinatal asphyxia newborns, especially to those belonging to the newborns characterised by the worst outcome. The results offer several hints on a shared metabolic derangement between different mechanisms of asphyxia/hypoxia. To the best of the authors’ knowledge, this is the first report of the use of a metabolomic approach in a pathological case, in which metabolomics offers useful additional information regarding the mechanism and the cause of death.
On the receiving end: have patient perceptions of the side-effects of cancer chemotherapy changed since the twentieth century?
Authors: Vardy Janette L. , Liew Andre , Warby Anne , Elder Alexander , Keshet Itay , Devine Rhonda , Ouliaris Calina , Renton Corrinne , Tattersall Martin H. N. , Dhillon Haryana M. 
Published: January 2022

AbstractBackgroundStudies in 1983 and 1993 identified and ranked symptoms experienced by cancer patients receiving chemotherapy. We repeated the studies to obtain updated information on patient perceptions of chemotherapy-associated symptoms.Patients and methodsA cross-sectional interview and patient-reported outcome questionnaires were administered to out-patients receiving chemotherapy. Patients selected from 124 cards to identify and rank the severity of physical and non-physical symptoms they had experienced and attributed to chemotherapy (primary endpoint). The patient’s medical oncologist and primary chemotherapy nurse were invited to rank the five symptoms they believed the patient would rank as their most severe. We analysed the association of symptoms and their severity with patient demographics, chemotherapy regimen, and patient-reported outcomes. Results were compared to the earlier studies.ResultsOverall, 302 patients completed the interview: median age 58 years (range 17–85); 56% female; main tumour types colorectal 81 (27%), breast 67 (22%), lung 49 (16%); 45% treated with curative intent. Most common symptoms (reported by >50%) were: alopecia, general weakness, effects on family/partner, loss of taste, nausea, fatigue, difficulty sleeping, effects on work/home duties, and having to put life on hold. The most severe symptoms (ranked by >15% in top five) were: concern about effects on family/partner, nausea, fear of the future, fatigue, not knowing what will happen, putting my life on hold, and general weakness. Perceptions of doctors and nurses of patients’ symptom severity closely matched patients’ rankings.ConclusionsCompared to earlier studies, there was an increase in non-physical concerns such as effects on family and future, and a decrease in physical symptoms, particularly vomiting, but nausea, fatigue and general weakness remained bothersome.Highlights• Symptoms related to chemotherapy have changed over time, likely due to less toxic regimens and improvements in supportive care.• Effects on family/partner, fear of the future, not knowing what will happen, and “life on hold” were major issues for patients.• Vomiting has decreased but nausea, fatigue and general weakness remain common symptoms for chemotherapy patients.
Distance to first symptoms measured by the 6-min walking test differentiates between treatment success and failure in patients with degenerative lumbar disorders
Authors: Zeitlberger Anna M. , Sosnova Marketa , Ziga Michal , Gautschi Oliver P. , Regli Luca , Bozinov Oliver , Weyerbrock Astrid , Stienen Martin N. , Maldaner Nicolai 
Published: January 2022

Abstract
Purpose
The smartphone-based 6-min walking test (6WT) is an established digital outcome measure in patients undergoing surgery for degenerative lumbar disorders (DLD). In addition to the 6WTs primary outcome measure, the 6-min walking distance (6WD), the patient’s distance to first symptoms (DTFS) and time to first symptoms (TTFS) can be recorded. This is the first study to analyse the psychometric properties of the DTFS and TTFS.

Methods
Forty-nine consecutive patients (55 ± 15.8 years) completed the 6WT pre- and 6 weeks (W6) postoperative. DTFS and TTFS were assessed for reliability and content validity using disease-specific patient-reported outcome measures. The Zurich Claudication Questionnaire patient satisfaction subscale was used as external criterion for treatment success. Internal and external responsiveness for both measures at W6 was evaluated.

Results
There was a significant improvement in DTFS and TTFS from baseline to W6 (p < 0.001). Both measures demonstrated a good test–retest reliability (β = 0.86, 95% CI 0.81–0.90 and β = 0.83, 95% CI 0.76–0.87, both p < 0.001). The DTFS exceeded the 6WD capability to differentiate between satisfied (82%) and unsatisfied patients (18%) with an AUC of 0.75 (95% CI 0.53–0.98) vs. 0.70 (95% CI 0.52–0.90). The TTFS did not demonstrate meaningful discriminative abilities.

Conclusion
Change in DTFS can differentiate between satisfied and unsatisfied patients after spine surgery. Digital outcome measures on the 6WT metric provide spine surgeons and researchers with a mean to assess their patient’s functional disability and response to surgical treatment in DLD.
Complete genome sequence of a new quadrivirus infecting a member of the genus Thelonectria
Authors: Lutz Tobias , Langer Gitta , Heinze Cornelia 
Published: January 2022

AbstractA novel dsRNA virus named “Thelonectria quadrivirus 1” (TQV1) was found in a member of the genus Thelonectria (Ascomycota), isolated from a root associated with stem collar necrosis of Fraxinus excelsior L. The complete genome of TQV1 is composed of four segments, each containing a single ORF on the positive sense RNA. The sequence of the 5´ (5´-(C/T)ACGAAAAA-3´) and 3´termini (5´AT(T/G)AGCAATG(T/C)GC(G/A)CG-3’) of dsRNA 1 (4876 bp), dsRNA 2 (4312 bp), dsRNA 3 (4158 bp), and dsRNA 4 (3933 bp) are conserved. Based on its genome organization and phylogenetic position, TQV1 is suggested to be a new member of the family Quadriviridae. This is the first report of a mycovirus infecting a member of the genus Thelonectria.
Loanable funds versus money creation in banking: a benchmark result
Authors: Faure Salomon , Gersbach Hans 
Published: January 2022

AbstractWe establish a benchmark result for the relationship between the loanable-funds and the money-creation approach to banking. In particular, we show that both processes yield the same allocations when there is no uncertainty. In such cases, using the much simpler loanable-funds approach as a shortcut does not imply any loss of generality. When there is aggregate risk with complete contracts and complete markets, we indicate that a restricted equivalence result holds.
Many people admitted to hospital with a provisional diagnosis of nonserious back pain are subsequently found to have serious pathology as the underlying cause
Authors: Melman Alla , Maher Chris G. , Needs Chris , Machado Gustavo C. 
Published: January 2022

AbstractTo determine the proportion of patients admitted to the hospital for back pain who have nonserious back pain, serious spinal, or serious other pathology as their final diagnosis. The proportion of nonserious back pain admissions will be used to plan for future ‘virtual hospital’ admissions. Electronic medical record data between January 2016 and September 2020 from three emergency departments (ED) in Sydney, Australia were used to identify inpatient admissions. SNOMED-CT-AU diagnostic codes were used to select ED patients aged 18 and older with an admitting diagnosis related to nonserious back pain. The inpatient discharge diagnosis was determined from the primary ICD-10-AM codes by two independent clinician-researchers. Inpatient admissions were then analysed by sociodemographic and hospital admission variables. A total of 38.1% of patients admitted with a provisional diagnosis of nonserious back pain were subsequently diagnosed with a specific pathology likely unsuitable for virtual care; 14.2% with a serious spinal pathology (e.g., fracture and infection) and 23.9% a serious pathology beyond the lumbar spine (e.g., pathological fracture and neoplasm). A total of 57% of admissions were identified as nonserious back pain, likely suitable for virtual care. A challenge for implementing virtual care in this setting is screening for patients with serious pathology. Protocols need to be developed to reduce the risk of patients being admitted to virtual hospitals with serious pathology as the cause of their back pain.

Key Points• Among admitted patients provisionally diagnosed in ED with non-serious back pain,
38.1% were found to have ‘serious spinal pathologies’ or ‘serious pathologies beyond the lumbar spine’ at discharge.• Spinal fractures were the most common serious spinal pathology, accounting for 9%
of all provisional ‘non-serious back pain’ admissions from ED.• 57% of back pain admissions were confirmed to be non-serious back pain and may be
suitable to virtual hospital care; the challenge is discriminating these patients from
those with serious pathology.
Digital transformation of everyday lives of older Swiss adults: use of and attitudes toward current and future digital services
Authors: Seifert Alexander , Charness Neil 
Published: January 2022

AbstractDigital (consumer) services, such as ticket machines, self-checkout, and online reservations, have become increasingly important in modern society. Studies on adoption of these services and openness to using future public digital services (e.g., online voting, online taxes, electronic patient records) have mostly focused on younger adults or nonrepresentative samples among older adults. Therefore, two important questions remain that can best be addressed with representative sampling: To what extent do older adults use or are willing to use current and future digital services in their everyday lives? How do older adults evaluate the ease of use of these services?. The study included data on use of current and future digital services among a large Swiss sample of 1149 people age 65 years and older (mean age: 74.1 years, SD: 6.69). Descriptive and multivariate analyses showed that (a) established services such as cash machines were used more often than new services, such as self-checkout apps or machines. (b) Perceived ease of use is related to age, socioeconomic status, health, and interest in technology. (c) Only 8.9% had an overall positive attitude toward these digital services, and this attitude was predicted by age, gender, socioeconomic status, and interest in technology. (d) Participants were more often open to filing taxes online than voting online, and openness was predicted by age, income, and interest in technology. Today, mainly older adults with a high interest in technology use digital services. Nevertheless, potential for greater use is evident.
Hitting the target and missing the point? On the risks of measuring women’s empowerment in agricultural development
Authors: Tavenner Katie , Crane Todd A. 
Published: January 2022

AbstractThere is a strong impetus in international agricultural development to close ‘gender gaps’ in agricultural productivity. The goal of empowering women is often framed as the solution to closing these gaps, stimulating the proliferation of new indicators and instruments for the targeting, measurement, and tracking of programmatic goals in research for agricultural development. Despite these advances, current measurements and indices remain too simplified in terms of unit and scope of analysis, as well as being fundamentally flawed in how they aim to capture the relevance of ‘gender’ in diverse local contexts. We propose that the impulse to apply exogenously defined and weakly validated ‘women’s empowerment’ measures to diverse local contexts risks prioritizing practical expedience over scientific accuracy and societal relevance. Furthermore, the application of such measures risks creating the impression that programmatic “gender targets” are being achieved, while simultaneously undermining substantive gender transformative goals. The authors conclude that a different methodological approach grounded in participatory and qualitative methods is needed to create more meaningful metrics for assessing progress towards women’s empowerment.
Responsible I(m)ovation in Asia Pacific regions
Authors: Scuotto Veronica , Garcia-Perez Alexeis , Kalisz David E. , Dhir Amandeep 
Published: January 2022

AbstractOver the past 20 years, a debate has developed on the differences between innovation and imitation strategies as mechanisms by which businesses operating in the Asia Pacific region may gain a competitive advantage. The current research contributes to this debate from a different perspective by exploring some of the challenges and opportunities associated with the combination of both strategies into what has been defined as imovation. Imovators and imovations do not stand alone in business ecosystems. Rather, they should be embraced in the context of sustainability-related virtues and emerging capabilities, such as ethical behaviour, co-responsibility and positive social impact. Taking dynamic capabilities as a theoretical lens, this paper conducts an empirical investigation of responsible imovation in a sample of 180 enterprises operating in the Asia Pacific market. In particular, this research evaluates the relationship between dynamic capabilities and imovation capabilities using a logistic regression analysis whereby we correlate the three main features of imovation strategies: strategic alliances, strategic decision-making and product innovations. To the best of our knowledge, ours is the first study to focus on responsible imovation in the Asia Pacific market from an empirical perspective. The research highlights the key organisational and individual actions with the potential both to preserve existing capabilities and to create and integrate new ones. Our findings highlight the importance of technology adoption for responsible imovation to become more effective and accessible to imovators in the Asia Pacific business ecosystem. We conclude that responsible imovations combined with product-level innovations and core dynamic capabilities pave the way towards more rapid growth and a more sustainable competitive advantage.
Derived blockchain architecture for security-conscious data dissemination in edge-envisioned Internet of Drones ecosystem
Authors: Singh Maninderpal , Aujla Gagangeet Singh , Bali Rasmeet Singh 
Published: January 2022

AbstractInternet of Drones (IoD) facilitates the autonomous operations of drones into every application (warfare, surveillance, photography, etc) across the world. The transmission of data (to and fro) related to these applications occur between the drones and the other infrastructure over wireless channels that must abide to the stringent latency restrictions. However, relaying this data to the core cloud infrastructure may lead to a higher round trip delay. Thus, we utilize the cloud close to the ground, i.e., edge computing to realize an edge-envisioned IoD ecosystem. However, as this data is relayed over an open communication channel, it is often prone to different types of attacks due to it wider attack surface. Thus, we need to find a robust solution that can maintain the confidentiality, integrity, and authenticity of the data while providing desired services. Blockchain technology is capable to handle these challenges owing to the distributed ledger that store the data immutably. However, the conventional block architecture pose several challenges because of limited computational capabilities of drones. As the size of blockchain increases, the data flow also increases and so does the associated challenges. Hence, to overcome these challenges, in this work, we have proposed a derived blockchain architecture that decouples the data part (or block ledger) from the block header and shifts it to off-chain storage. In our approach, the registration of a new drone is performed to enable legitimate access control thus ensuring identity management and traceability. Further, the interactions happen in the form of transactions of the blockchain. We propose a lightweight consensus mechanism based on the stochastic selection followed by a transaction signing process to ensure that each drone is in control of its block. The proposed scheme also handles the expanding storage requirements with the help of data compression using a shrinking block mechanism. Lastly, the problem of additional delay anticipated due to drone mobility is handled using a multi-level caching mechanism. The proposed work has been validated in a simulated Gazebo environment and the results are promising in terms of different metrics. We have also provided numerical validations in context of complexity, communication overheads and computation costs.
Pension Participants’ Attitudes, Beliefs, and Emotional Responses to the New Dutch Pension System
Authors: van Hekken Annemarie , Hoofs Jorn , Brüggen Elisabeth Christine 
Published: January 2022

AbstractAs of 2022, the Dutch pension system will be overhauled. The success of this as well as other pension reforms also depends on how participants react to and accept such changes. We therefore studied participants’ attitudes, beliefs, and emotions toward the new pension system. We composed a text to inform them about the new system and qualitatively analyzed their responses. We investigated which beliefs and attitudes prevail among different age groups. The results show that many participants base their comments on previous experiences, misconceptions and (sometimes false) interpretations of the information in the text. Moreover, we find that young people are more optimistic, whilst older participants tend to feel victimized. Since the new Dutch pension rules have yet to be introduced, the results of our study contain valuable information for policymakers and pension funds who should acknowledge and address the oftentimes intense emotions, beliefs, and attitudes that influence the way that intentionally neutral information is perceived and accepted. A diversified communication strategy, mindful of different beliefs, emotions and attitudes among participants should help to empower citizens to get insight in their financial situation after retirement and to make informed choices.
Learning how to search: generating effective test cases through adaptive fitness function selection
Authors: Almulla Hussein , Gay Gregory 
Published: January 2022

AbstractSearch-based test generation is guided by feedback from one or more fitness functions—scoring functions that judge solution optimality. Choosing informative fitness functions is crucial to meeting the goals of a tester. Unfortunately, many goals—such as forcing the class-under-test to throw exceptions, increasing test suite diversity, and attaining Strong Mutation Coverage—do not have effective fitness function formulations. We propose that meeting such goals requires treating fitness function identification as a secondary optimization step. An adaptive algorithm that can vary the selection of fitness functions could adjust its selection throughout the generation process to maximize goal attainment, based on the current population of test suites. To test this hypothesis, we have implemented two reinforcement learning algorithms in the EvoSuite unit test generation framework, and used these algorithms to dynamically set the fitness functions used during generation for the three goals identified above. We have evaluated our framework, EvoSuiteFIT, on a set of Java case examples. EvoSuiteFIT techniques attain significant improvements for two of the three goals, and show limited improvements on the third when the number of generations of evolution is fixed. Additionally, for two of the three goals, EvoSuiteFIT detects faults missed by the other techniques. The ability to adjust fitness functions allows strategic choices that efficiently produce more effective test suites, and examining these choices offers insight into how to attain our testing goals. We find that adaptive fitness function selection is a powerful technique to apply when an effective fitness function does not already exist for achieving a testing goal.