bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of fast track co-management care model on perioperative neurocognitive disorders in older patients undergoing hip fracture surgery: a multicenter retrospective cohort study
Authors: Luo Taijun , Zhang Wenchao , Duan Fangfang , Xiao Rui , Xu Tao , Wang Geng , Yang Minghui , Wu Xinbao 
Published: December 2022

Abstract
Background: This paper attempts to compare the effect of a co-management care model with a traditional orthopedic model on perioperative neurocognitive disorders complications in elderly hip fracture patients.
Methods: In this study, elderly hip fracture patients attending six hospitals in Beijing from November 31, 2018 to November 31, 2020 were divided into co-management care model and traditional orthopedic model according to the intention-to-treat principle. Beijing Jishuitan Hospital implemented a rapid co-management care model (OGC group), and five Beijing hospitals, including Beijing Anzhen Hospital, implemented a traditional orthopedic model (TOC group). The study used the Confusion Assessment Method (CAM) and a modified telephone interview method targeting patients' cognitive status to assess the incidence of delirium in elderly patients.
Results: A total of 2071 elderly hip surgery patients were included in the study, excluding 128 patients who received conservative treatment and 119 patients who were withdrawn from follow-up. Ultimately, 995 patients in the OGC group and 829 patients in the TOC group were included in the follow-up analysis. The incidence of perioperative neurocognitive disorders was significantly lower in the OGC group than in the TOC group (20.5% vs 69.5%, OR 0.59, 95% CI:0.53~0.65, P=0.000); the incidence of preoperative delirium was significantly lower in the OGC group than in the TOC group (10.5% vs 16.9%, OR 0.64, 95% CI:0.47-0.70, P=0.000); the incidence of postoperative delirium was also lower in the OGC group than in the TOC group (19.1% vs. 22.6%, OR 0.67, 95% CI:0.58 ~ 0.77, =0.001). Our logistic multivariate analysis also showed that the rapid fast-track co-management care model may be a protective factor against the development of neurocognitive impairment in patients in the perioperative period.
Conclusion: The fast-track co-management care model can reduce the occurrence of perioperative neurocognitive disorders in elderly patients, which is worth being promoted in clinical treatment. Key words: hip fracture, fast track, co-management care model, delirium, perioperative neurocognitive disorders.
RPL11 promotes non-small cell lung cancer cell proliferation via regulating endoplasmic reticulum stress and cell autophagy
Authors: Chen Jie , Lei Changda , Zhang Huahua , Huang Xiaoyong , Yang Yang , Liu Junli , Jia Yuna , Shi Haiyan , Zhang Yunqing , Zhang Jing , Du Juan 
Published: December 2022

Abstract
Background
Abnormal ribosomal proteins (RPs) biogenesis and function works importantly in tumorigenesis and development. RPL11 is a component of ribosomal 60S large subunit has different roles in different cancers. Here, we aims to unravel the novel functions of RPL11 in non-small cell lung cancer (NSCLC), especially that affecting cell proliferation.
Methods
Expression level of RPL11 in different NSCLC cell lines was detected using western blotting. The function of RPL11 in NSCLC cells were CCK-8, colony formation and scratch wound healing detected. Mechanisms of RPL11 on NSCLC cells proliferation were explored by flow cytometry, autophagy detection, and usage of an autophagy inhibitor chloroquine (CQ) and ERS inhibitor (TUDCA) .
Results
We found that RPL11 was highly expressed in NSCLC cells. Additionally, RPL11 overexpression promoted NSCLC cells proliferation and migration in vitro, and promoted the transition from G1 phase to S phase of the cell cycle. Conversely, RPL11 inhibition suppressed NSCLC cell proliferation and migration, and arrested the cell cycle in G0/G1 phase. Moreover, RPL11 promotes NSCLC cell proliferation via modulating autophagy and ERS. Expression levels of autophagy and ERS markers were induced by RPL11 overexpression, and inhibited by siRPL11. Usage of an autophagy inhibitor chloroquine (CQ) partially reverse the promotion of RPL11 on NSCLC cells proliferation. Besides, RPL11 induced autophagy markers expression could partially reversed by the ERS inhibitor (TUDCA).
Conclusions
Taken together, RPL11 has a tumor-promoting role in non-small cell lung cancer. It promote the cell proliferation of NSCLC cells by regulating ERS and autophagy.
Does the Implementation of Home-based Care Service Policy Improve the Quality of Life for the Elderly? Evidence from 28 Provinces in China
Authors: Zhang Xue , Dai Jing , Li Wei , Liu Yang , Wang Zongyue , Liu Zhuo , Tamoor Azam 
Published: December 2022

Abstract
Purpose: To evaluate the policy treatment effects of home-based care service scientifically and identify the key intervention groups of home-based care services accurately in China.
Methods: The data set was obtained from China Health and Retirement Longitudinal Study (CHARLS) in 2018. The elderly over 60 years old were selected as the study subjects. The factors analysis method was used to construct the evaluation index of the quality of life (QoL). The ordinary least squares (OLS) model and the propensity score matching (PSM) method were adopted to analyze the impact and heterogeneity of home-based care services on the QoL. The substitution variable method and the change measurement model method were chosen to test the stability of the model.
Results: (1) From the perspective of the utilization rate of home-based care services, the utilization rate of home-based care services were generally low in China. The utilization rate of medical services was 23.37, whereas the life care service was 3.64%. Moreover, there was a serious regional imbalance in China. (2) From the point of view of the policy treatment effects of home-based care service, it had a positive policy effect on the QoL of the elderly. The intervention effect of medical care service on QoL was 0.030 standard points and the life care service on QoL was 0.034 standard points. (3) The heterogeneity test showed that medical care services had a prominent effect on improving the QoL of the low-age, rural, and without spouse elderly; Life care services had an obvious effect on prompting the QoL of the elderly aged 80 and above, rural, and without spouse senior.
Conclusion: The home-based care service can improve the QoL of the elderly in China, and it plays a prominent role in promoting the QoL of the key target seniors. Nevertheless, there is an imbalance in home-based care service supply, especially the small- scale and low-quality supply of life care services, which leads to certain areas missing the sensitive intervention period.
Changes in HER3 expression profiles between primary and recurrent gynecological cancers
Authors: Kojima Yuki , Sudo Kazuki , Yoshida Hiroshi , Yazaki Shu , Tokura Momoko , Mizoguchi Chiharu , Okuma Hitomi S , Kita Shosuke , Yamamoto Kasumi , Nishikawa Tadaaki , Noguchi Emi , Shimoi Tatsunori , Tanase Yasuhito , Uno Masaya , Ishikawa Mitsuya , Kato Tomoyasu , Koyama Kumiko , Kobayashi Maki , Kakegawa Tomoya , Fujiwara Yasuhiro , Yonemori Kan 
Published: December 2022

Abstract
Background: Human epidermal growth factor receptor-3 (HER3) is a member of the epidermal growth factor receptor family of receptor tyrosine kinases, and its overexpression is associated with inferior prognosis in several cancers. However, it is unclear whether HER3 expression status changes in tumor tissue at recurrence. Therefore, this study aimed to evaluate the changes in HER3 expression between primary and recurrent status in gynecological cancers.
Methods: This retrospective study used matched-pair tissues of gynecological cancer patients at initial diagnosis and at recurrence. Immunohistochemical (IHC) scores of 3+ or 2+ were termed “HER3-high”, while IHC scores of 1+ or 0 were designated as “HER3-low/zero”.
Results: A total of 86patients (40 with ovarian cancers, 32 with endometrial cancers, and 14 with cervical cancers) were included in this study. In ovarian cancer, 67.5% and 80.0% of the patients received a HER3-high at initial and recurrent diagnosis, respectively. The H-score was significantly increased at recurrence (p=0.004). The proportion of HER3-high endometrial cancer patients increased from 46.9% at initial diagnosis to 68.8% at recurrence, and the H-score tended to increase at recurrence (p=0.08). The fraction of HER3-high-rated cervical cancer patients remained unchanged at 85.7% both at initial and recurrent diagnosis. The discordance rate of HER3 expression detection in initial and recurrent diagnosis samples was 27.5%, 53.1%, and 14.3% for ovarian, endometrial, and cervical cancers, respectively. Ovarian and endometrial cancers with a HER3-high recurrent score tended to show shorter median survival time than those with a HER3-low/zero recurrent rating.
Conclusion: Our findings suggest that, in gynecological cancers, the proportion of patients having a HER3-high score increased from initial to recurrent diagnosis.
Box-Behnken Modeling and Optimization of Visible-Light Photocatalytic Removal of Methylene Blue by ZnO-BiFeO3 Composite
Authors: Ehsani Fatemeh , Shaveisi Yaser , Sharifnia Shahram 
Published: December 2022

Abstract
Box-Behnken experimental design was utilized to model and optimize the photocatalytic removal of methylene blue (MB) using ZnO-BiFeO3 composite under visible light (LED). Three catalysts with different ZnO: BiFeO3 molar ratios (2:1, 1:2, and 1:1) were synthesized successfully using hydrothermal method. The synthesized photocatalysts were characterized by XRD, FESEM, EDX, PL, FTIR, and UV-vis. FESEM showed the uniform distribution of ZnO particles over the surface of bigger BiFeO3 particles. The best photocatalytic activity was obtained by ZnO-BiFeO3 with 2:1 molar ratio. In order to optimize the experimental conditions, four factors of initial MB concentration (5 to 20 mg/L), pH (3 to 12), catalyst dosage (0.5 to 1.25 mg/L) and light intensity (4 to 18 W) were selected as independent input variables. BBD suggested a quadratic polynomial equation to fit the experimental data. Results of ANOVA confirmed the goodness of fit for the suggested model (predicted- and adjusted-R2 0.99). The optimum conditions for maximizing the photocatalytic MB degradation were found to be initial MB concentration of 11 mg/L, pH of 11.7, catalyst dosage of 0.716 mg/L, and light intensity of 11.4 W. Under the optimum conditions, the highest photocatalytic MB degradation of 62.9% was obtained which is in reasonable agreement with the predicted value of 69%.
Florfenicol Sustained-release Granules: An in Vitro release and pharmacokinetics study in pigs
Authors: YANG Wei-cong , Zi-yao LIU , ZHANG Yun-xiao , Yang YU , SHEN Yue , XU Ying , HUANG Xian-hui 
Published: December 2022

Abstract
The aim of the present study was to synthesize and characterize florfenicol sustained-release granules (FSRGs) in vitro and in vivo. FSRGs were synthesized using monostearate, polyethylene glycol 4000 and amylum starch. In vitro dissolution profiles were studied using the rotating basket method in pH1.2 HCl solution and pH 4.3 acetate buffer. Twenty-four male healthy Landrace×Yorkshire pigs were equally divided into three groups and administered a 20 mg/kg i.v bolus of florfenicol solution and dosed orally with FSRGs in fasted and fed condition. The Higuchi model was the best fit for the drug release profile in pH1.2 and pH 4.3 media and the mechanism of drug dissolution was governed by both diffusion and dissolution. We established a level A in vitro - in vivo correlation for FSRGs and the in vivo profile of the FSRGs can be estimated by the in vitro drug release
Gendered late working life trajectories, family history and welfare regimes: Evidence from SHARELIFE
Authors: Schmitz Wiebke , Naegele Laura , Frerichs Frerich , Ellwardt Lea 
Published: December 2022

Abstract
Background
Earlier employment choices based on family events in earlier life have an impact up until late working life. Especially in welfare regimes that encourage the breadwinner-caretaker division. We investigate types of late employment patterns and how these are associated with earlier family events. Third, we test whether the association between early family history and late working life varies across five welfare regimes.
Methods
We use retrospective life history data from SHARELIFE. Our sample consists of 10,944 women and 10,662 men aged 65 years and older. Late working life trajectories are analyzed using gender-separate sequence analyses, which are summarized into eight groups applying cluster analyses. Using average marginal and interaction effects we explain how the association between types of late working life, coresidential partnership history and parenthood history differs by welfare states.
Results
Women’s late employment is either shaped by unpaid care or paid (full- or part-time) work but not both, whereas men’s late working life is mainly shaped by full-time work. Family history in earlier life is linked to unpaid care and part-time work – this association is strongest in liberal and southern welfare regimes. However, among men earlier family events are linked to full-time work.
Discussion
Policymakers need gender-specific strategies to integrate workers into late working life. The implementing of new policies should aim to prevent these social inequalities in early life, as employment decisions caused by family history in earlier life stages – especially for women – tend to cumulate over the life course.
WWOX Binds MERIT40 and Modulates Its Function in Homologous Recombination, Implications in Breast Cancer
Authors: Lallemand Francois , Taouis Karim , Vacher Sophie , Guirouilh-Barbat Josée , Camonis Jacques , Formstecher Etienne , Popova Tatiana , Hamy Anne-Sophie , Petitalot Ambre , Lidereau Rosette , Caputo Sandrine , Zinn-Justin Sophie , Bieche Ivan , DRIOUCH Keltouma 
Published: December 2022

Abstract
The tumor suppressor gene WWOX is localized in an unstable chromosomal region and its expression is decreased or absent in several types of cancer. A low expression of WWOX is associated with a poor prognosis in breast cancer (BC). It has recently been shown that WWOX contributes to genome stability through its role in the DNA damage response (DDR). In breast cancer cells, WWOX inhibits homologous recombination (HR), and thus promotes the repair of DNA double-stranded breaks (DSBs) by non-homologous end joining (NHEJ). The fine-tuning modulation of HR activity is crucial. Its under or overstimulation inducing genome alterations that can induce cancer. MERIT40 is a positive regulator of the DDR. This protein is indispensable for the function of the multi-protein complex BRCA1-A, which suppresses excessive HR activity. MERIT40 also recruits Tankyrase, a positive regulator of HR, to the DSBs to stimulate DNA repair. Here, we identified MERIT40 as a new molecular partner of WWOX. We demonstrated that WWOX inhibited excessive HR activity induced by overexpression of MERIT40. We showed that WWOX impaired the MERIT40-Tankyrase interaction preventing the role of the complex on DSBs. Furthermore, we found that MERIT40 is overexpressed in BC and that this overexpression is associated to a poor prognosis. These results strongly suggest that WWOX, through its interaction with MERIT40, prevents the deleterious impact of excessive HR on BC development by inhibiting MERIT40-Tankyrase association. This inhibitory effect of WWOX would oppose MERIT40-dependent BC development.
Chondrichthyan fauna from the Marine Protected Area Namuncurá at Burdwood Bank: exploring egg nursery grounds
Authors: Florencia Matusevich , Vazquez Diego Martín , Gabbanelli Valeria , Astarloa Juan Martín Díaz , Mabragaña Ezequiel 
Published: December 2022

Abstract
The Burdwood Bank (BB) is a subantarctic area, where two of the three Marine Protected Areas (MPA) of the Argentinean Exclusive Economic Zone are located: Namuncurá I, and Namuncurá II. The area is characterized by a high biodiversity of benthic invertebrates and teleost fishes; however, the available information on oviparous chondrichthyans is scarce. The aim of this study is to explore the potential reproductive use that oviparous chondrichthyans could make of the area based on the presence of egg-laying grounds. Additionally, we aim to provide an updated checklist of the species that inhabit the BB. Samples of specimens and egg capsules collected in four research cruises carried out between 2016 and 2018 were analyzed. Seven skate species were found in both MPAs: Amblyraja doellojuradoi, Bathyraja albomaculata, B. brachyurops, B. macloviana, B. multispinis, B. scaphiops, and Psammobatis rudis; whereas B. cousseauae, and B. magellanica were found exclusively in Namuncurá I. Here we report, for the first time, the presence of egg laying grounds for five chondrichthyan species in the BB area: A. doellojuradoi, B. brachyurops, B. macloviana, B. scaphiops, and P. rudis. The results obtained highlighted the importance of the region for the conservation of oviparous chondrichthyans found in the southern Patagonian shelf.
Mapping inundation from sea-level rise and its interaction with land cover in the Sundarbans mangrove forest
Authors: Kanan Akbar Hossain , Masiero Mauro , Rahman Md Masudur , Pirotti Francesco 
Published: December 2022

Abstract

The sea level rise (SLR) in the Sundarbans areas is higher than the global-average rate of sea rise, and many studies assume that most of the dry land of the Sundarbans will be inundated by the end of the twenty-first century. This study aims to analyse the amount of dry land that can potentially be inundated by SLR in Sundarbans and the impact under different land cover conditions. We applied geospatial data from a Digital Elevation Model (DEM), four SLR scenarios, and net subsidence data to map future inundated areas and discuss the impacts. Results for the low (35 cm), mid (52 cm), high (70 cm), and extreme (147 cm) SLR scenarios indicate that the Sundarbans landmass area will be flooded up to 40 km2 (1%), 72 km2 (1.8%), 136 km2 (3.4%), and 918 km2 (23%) respectively, under the current net subsidence rate of -2.4 mm/year. Except for the extreme scenarios, the low, mid, and high SLR will result in riverbank and beach areas to be covered by water. Thus, the potential inundation areas of different vegetation cover classes that already exist today (2020) will be of low significance for the low, mid, and high SLR scenarios. We also analysed the sensitivity of the results through station-based SLR data, which fits with the low (35 cm) SLR scenarios under the − 2.4 mm/year subsidence rate. This study concluded that the inundation aspect of SLR would not directly affect the Sundarbans; however, other related threats and anthropogenic disturbances can be major drivers of Sundarbans' degradation by the end of the twenty-first century. The study's findings might contribute to forest management planning and achieving some goals of the Bangladesh Delta Plan.
Quantitative indices of F-18 FDG PET/CT in assessing cardiovascular and non-cardiovascular manifestations of IgG4-related disease and treatment response
Authors: Chen Mingwei , Tang Charlene Yu Lin , Fong Warren Weng Seng , Lam Winnie Wing-Chuen 
Published: December 2022

Abstract
Background
IgG4-related disease (IgG4-RD) is a heterogenous autoimmune disorder characterised by inflammatory lesions. Diagnostic imaging, such as FDG PET/CT, is critical in evaluation of the disease, especially for potentially lethal cardiovascular manifestations. This retrospective study examines the usefulness of semi-quantitative parameters of FDG PET/CT in monitoring IgG4-RD in patients with and without cardiovascular manifestations.
Methods
Patients diagnosed with IgG4-RD who underwent a FDG PET/CT scan were identified and classified based on presence or absence of cardiovascular disease. Clinical and laboratory data were extracted and compared to three FDG PET/CT semiquantitative parameters: standardised uptake value (SUV), metabolic tumour volume (MTV), and total lesion glycolysis (TLG). These data were also compared in patients before and after receiving immunosuppressive therapy.
Results
Forty-six patients identified were divided into an eight member subgroup of patients with cardiovascular manifestations, and a thirty-eight member subgroup of patients without. Patients with cardiovascular lesions were most frequently identified incidentally on imaging evaluation for other diseases (37.5%), with none presenting with chest pain or other cardiovascular symptoms. Ten patients with pre-treatment and post-treatment FDG PET/CT scans demonstrated significant decreases in all semiquantitative parameters, with no significant decrease in total IgG or ESR. The decrease in SUVmax, MTV, and TLG following therapy was replicated in patients with and without cardiovascular manifestations.
Conclusion
FDG PET/CT is an important investigation to determine all sites of involvement in this multisystemic disease, and to rule out life-threatening cardiovascular manifestations even in the absence of symptoms. Semi-quantitative parameters such as SUVmax, MTV, and TLG are useful in assessing treatment response in patients with or without cardiovascular manifestations. There are no serological substitutes that can quantify the extent of disease involvement like FDG PET/CT.
Poverty Dynamics and the Role of Antipoverty Policy: Panel Evidence from Korea
Authors: Kim Sung-Geun , Ko KilKon 
Published: December 2022

Abstract
This study empirically analyzes whether the Korean government’s anti-poverty policy called the National Basic Livelihood Security System (NBLSS) effectively reduces poverty. To improve previous analyses in literature, we take the dynamic transitions of poverty status over years into account and evaluate the program effectiveness by comparing it with an imaginary situation where the NBLSS does not exist. We employed the Korea Welfare Panel Study data set, which collects detailed information on family structure, income, and employment status for poor, working poor, and near poor from 2005 to 2020, covering on average more than 6,000 households. In addition, to overcome the traditional event history model assuming left-censoring—and not considering the multiple status of dependent variables over years—we used multistate modeling, which allows us to model transitions between poverty and non-poverty dynamically with no bias from truncation. Our findings suggest the NBLSS is in general not effective, given that a model with the NBLSS does not make a significant difference in supporting people to get out of poverty from one without the NBLSS. However, it is found that it is quite effective for 1-person families, a family type that already takes up more than a third of all family type in the country. Also, it should be noted that the transition matrix shows that on average the probability of coming out of poverty is more than twice larger than the probability of falling into poverty, which implies a high upward mobility in terms of poverty. Still, the program should be improved by weakening the principle of subsidiarity.