bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using a Workplace Rehabilitation and Reintegration Program Tracker Tool to Explore Factors Associated With Return to Duty Among Ill/Injured Military Personnel: A Preliminary Analysis
Authors: Lee Jennifer E C , Coulthard Julie 
Published: August 2022

ABSTRACT

Introduction
A great deal of time and resources have been spent on developing and implementing evidence-based return to work programs over the past few decades, compelling researchers to better understand the factors associated with more favorable outcomes. Using data collected as part of a participant tracking system trial for the Canadian Armed Forces (CAF) Return to Duty (RTD) program, analyses were conducted to better understand the trajectories of program participants and identify the factors associated with RTD.

Materials and Methods
Participants included 205 Regular Force CAF members from a single military base located in Eastern Canada who entered the RTD program during the trial period between April 2018 and March 2020. The health condition they were facing was mostly recent (i.e., onset within the past 6 months; 43%) and involved their mental health (67%). Data were collected on various demographic, military, health, and program characteristics using the RTD Data Collection Tool, which was updated periodically by program coordinators. Using data gathered by the Tool, a cumulative incidence function was generated to estimate the overall marginal probability of RTD over the duration of the program. Associations between RTD and a range of factors that were captured using the Tool were also examined in a series of competing-risks regressions.

Results
Findings indicated that the rate of RTD among program participants increased at around 3 months and began to level off around 9 months, suggesting that the likelihood of RTD after this window is diminished. Of the many factors that were considered, only years of service and work placement status at 3 months were found to be associated with RTD. Specifically, lower rates of RTD were observed among participants with 15 or more years of service compared to those with less than 5 years of service in the CAF and among those who were not yet assigned a work placement at 3 months relative to those who were.

Conclusion
This study represents a first step in addressing the gap in our current knowledge about the characteristics of CAF members participating in the RTD program and the factors associated with RTD. Several recommendations are made for improving the participant tracking system in view of enhancing the level and quality of information that is available to assess participants’ trajectories and inform further development of the program.
Comorbidity, life-style factors and healthcare utilization in incident chronic kidney disease: sex-specific analyses of claims data
Authors: Colombo Miriam Giovanna , Förster Christian , Wallwiener Stephanie , Hassdenteufel Kathrin , Hawighorst-Knapstein Sabine , Kirtschig Gudula , Chaudhuri Ariane , Dally Simon , Joos Stefanie 
Published: August 2022

AbstractBackgroundChronic kidney disease (CKD) is common in aging men and women. In contrast to other European countries, Germany lacks CKD registries. The aim of this study was to determine the incidence of CKD stages 2–5 in men and women in Germany. Furthermore, differences between the sexes in terms of comorbidities, potentially inappropriate medications (PIM), and healthcare utilization were examined.MethodsIn this retrospective observational study, claims data from members of a statutory health insurance fund aged 18 years or older with incident CKD between 2011 and 2018 were analyzed. Incident CKD was defined as having two confirmed diagnoses of CKD stages 2–5 from outpatient care or one primary or secondary diagnosis from inpatient care.ResultsThe age- and sex-standardized incidence of all CKD stages was 945/100 000 persons between 2011 and 2018. Incident CKD, especially stages 3 and 4, occurred more frequently in women, while the incidence of stages 2 and 5 was higher in men. While women visited their GP more frequently and were prescribed PIMs more often, men were more likely to visit a nephrologist and were more often hospitalized after the incident CKD diagnosis.ConclusionMore awareness needs to be raised towards the early detection of CKD and the use of PIMs, especially in women. Improved care coordination is needed to avoid an overprovision of patients with uncomplicated incident stages and ensure that patients with advanced CKD stages get timely access to specialist care.
Automated detection and quantification of brain metastases on clinical MRI data using artificial neural networks
Authors: Pflüger Irada , Wald Tassilo , Isensee Fabian , Schell Marianne , Meredig Hagen , Schlamp Kai , Bernhardt Denise , Brugnara Gianluca , Heußel Claus Peter , Debus Juergen , Wick Wolfgang , Bendszus Martin , Maier-Hein Klaus H , Vollmuth Philipp 
Published: August 2022

Abstract

Background
Reliable detection and precise volumetric quantification of brain metastases (BM) on MRI are essential for guiding treatment decisions. Here we evaluate the potential of artificial neural networks (ANN) for automated detection and quantification of BM.

Methods
A consecutive series of 308 patients with BM was used for developing an ANN (with a 4:1 split for training/testing) for automated volumetric assessment of contrast-enhancing tumors (CE) and non-enhancing FLAIR signal abnormality including edema (NEE). An independent consecutive series of 30 patients was used for external testing. Performance was assessed case-wise for CE and NEE and lesion-wise for CE using the case-wise/lesion-wise DICE-coefficient (C/L-DICE), positive predictive value (L-PPV) and sensitivity (C/L-Sensitivity).

Results
The performance of detecting CE lesions on the validation dataset was not significantly affected when evaluating different volumetric thresholds (0.001–0.2 cm3; P = .2028). The median L-DICE and median C-DICE for CE lesions were 0.78 (IQR = 0.6–0.91) and 0.90 (IQR = 0.85–0.94) in the institutional as well as 0.79 (IQR = 0.67–0.82) and 0.84 (IQR = 0.76–0.89) in the external test dataset. The corresponding median L-Sensitivity and median L-PPV were 0.81 (IQR = 0.63–0.92) and 0.79 (IQR = 0.63–0.93) in the institutional test dataset, as compared to 0.85 (IQR = 0.76–0.94) and 0.76 (IQR = 0.68–0.88) in the external test dataset. The median C-DICE for NEE was 0.96 (IQR = 0.92–0.97) in the institutional test dataset as compared to 0.85 (IQR = 0.72–0.91) in the external test dataset.

Conclusion
The developed ANN-based algorithm (publicly available at www.github.com/NeuroAI-HD/HD-BM) allows reliable detection and precise volumetric quantification of CE and NEE compartments in patients with BM.
Fungal dual-domain LysM effectors undergo chitin-induced intermolecular, and not intramolecular, dimerization
Authors: Tian Hui , Fiorin Gabriel L , Kombrink Anja , Mesters Jeroen R , Thomma Bart P H J 
Published: August 2022

Abstract
Chitin is a homopolymer of β-(1,4)-linked N-acetyl-D-glucosamine (GlcNAc) and a major structural component of fungal cell walls. In plants, chitin acts as a microbe-associated molecular pattern (MAMP) that is recognized by lysin motif (LysM)-containing plant cell surface-localized pattern recognition receptors (PRRs) that activate a plethora of downstream immune responses. To deregulate chitin-induced plant immunity and successfully establish infection, many fungal pathogens secrete LysM domain-containing effector proteins during host colonization. The LysM effector Ecp6 from the tomato (Solanum lycopersicum) leaf mold fungus Cladosporium fulvum can outcompete plant PRRs for chitin binding because two of its three LysM domains cooperate to form a composite groove with ultra-high (pM) chitin-binding affinity. However, most functionally characterized LysM effectors contain only two LysMs, including Magnaporthe oryzae MoSlp1, Verticillium dahliae Vd2LysM, and Colletotrichum higginsianum ChElp1 and ChElp2. Here, we performed modeling, structural, and functional analyses to investigate whether such dual-domain LysM effectors can also form ultra-high chitin-binding affinity grooves through intramolecular LysM dimerization. However, our study suggests that intramolecular LysM dimerization does not occur. Rather, our data support the occurrence of intermolecular LysM dimerization for these effectors, associated with a substantially lower chitin binding affinity than monitored for Ecp6. Interestingly, the intermolecular LysM dimerization allows for the formation of polymeric complexes in the presence of chitin. Possibly, such polymers may precipitate at infection sites to eliminate chitin oligomers, and thus suppress the activation of chitin-induced plant immunity.
The Effectiveness of Tuina in Relieving Pain, Negative Emotions, and Disability in Knee Osteoarthritis: A Randomized Controlled Trial
Authors: Xu Hui , Zhao Chi , Guo Guangxin , Li Yulin , A Xinyu , Qiu Guowei , Wang Yuxia , Kang Bingxin , Xu Xirui , Xie Jun , Xiao Lianbo 
Published: August 2022

AbstractObjectiveTo evaluate the effectiveness of Tuina in relieving the pain, negative emotions, and disability of patients with knee osteoarthritis (KOA).DesignSingle-center, parallel, randomized controlled trial.SettingShanghai Guanghua Integrated Chinese and Western Medicine Hospital, Shanghai, China.SubjectsAdult patients with KOA who were able to speak Chinese and self-report symptoms were eligible.MethodsA total of 104 patients were randomly allocated to receive the 6-week treatment of Tuina (Tuina group) or celecoxib (celecoxib group). Data on pain, negative emotions, and disability were collected at baseline, at week 2, 4, and 6, and follow-up (1 month after the last treatment). The primary outcomes were the pressure pain thresholds. The secondary outcomes were: (1) numerical rating scale at rest and with movement; (2) Hamilton Anxiety Scale; (3) Hamilton Depression Scale; (4) Western Ontario and McMaster Universities Osteoarthritis Index; and (5) clinical effective rate. The adverse events of the trial were evaluated.ResultsIn total, 99 patients completed the follow-up. Generalized linear mixed models were constructed to analyse the between-group differences. Statistically significant differences were found in the interaction effects (P &lt; .05). In evaluating the group effect, statistical differences were found at week 6 and follow-up (P &lt; .05). Further, all variables showed a time effect (P &lt; .05). A statistical difference in the clinical effective rate was found between the Tuina and celecoxib groups (P &lt; .05).ConclusionsTuina produced superior effects for pain, negative emotions, and disability over time, as compared to celecoxib in patients with KOA.
MITOCHONDRIA IN BIODOSIMETRY: FLOW CYTOMETRY ASSESMENT IN VITRO
Authors: Šinkorová Zuzana , Lierová Anna , Filipová Alžběta , Čížková Jana , Tichý Aleš , Pejchal Jaroslav , Milanová Marcela , Vilasová Zdena , Andrejsová Lenka 
Published: August 2022

Abstract
The JC-1 dye is widely used in apoptosis studies to monitor mitochondrial health. The probe was tested in vitro on two established cell lines and peripheral porcine blood lymphocytes after gamma irradiation (IR) to assess its potential in biodosimetric evaluation. In brief, we stained irradiated and non-irradiated cells with the JC-1 dye to determine the existing changes in mitochondrial membrane potential and monitor cell health through flow cytometry. The stage of injury in these cells was evaluated through an irradiated versus non-irradiated ratio (IVNIR), comparing the relative proportion of polarised cells containing red JC-1 aggregates. We observed a decreasing IVNIR as the radiation dose increased (i.e. 0.5; 1; 2; 4; 6; 8 and 10 Gy), performing the analysis at 4, 8 and 24 h after IR in all the tested cells. The results from the JC1-dye test showed that CD4 T lymphocytes were more sensitive to irradiation than other subpopulations.
PLASTIC SCINTILLATOR BASED 2D DETECTOR FOR PHOTON RADIOTHERAPY: PRELIMINARY RESULTS
Authors: Hanušová Tereza , Linhart Vladimír , Vrba Tomáš 
Published: August 2022

Abstract
A proof-of-concept study of a new detector based on a thin plastic scintillator monitored by a Charge-Coupled Device (CCD) camera designed for monitoring and characterisation of Linac photon beams is presented. The response of the detector is compared with radiochromic film using 6 and 18 MV radiotherapeutic beams. We have observed: (i) all instruments survived the secondary radiation fields during Linac operation, (ii) it was possible to process the measured data using statistical techniques and (iii) the processed data from the CCD camera qualitatively correspond to film dosimetry results. A statistical technique based on the selection of minimal values provides the clearest results. Quantitatively, CCD and film results can only be compared as 6 to 18 MV response rates. We have observed that the rates from the CCD data are systematically higher than the rates from film dosimetry. Differences are not too high, namely 1.9–2.4 times the combined standard deviation.
COMPARISON OF TWO TYPES EYE LENS DOSEMETERS USED IN INTERVENTIONAL CARDIOLOGY AND RADIOLOGY
Authors: Martinčík Jiří , Čechák Tomáš , Urban Tomáš , Tamášová Jana , Siková Lenka , Jakubcová Iva , Balogová Zdenka 
Published: August 2022

Abstract
The aim of this contribution is to provide an overview of comparison of two types of eye lens dosemeter systems. The comparison was performed at the Department of Intravenous Cardiology using patient and physician phantoms and supplemented by dose simulation using the Monte Carlo method. The tests were performed in several specific geometries and in addition to eye lens dosemeters the value of a personal dosemeter located at the reference point was also monitored. The value of Hp(3) and Hp(10) was monitored. It is clear from the results that film dosemeters achieve more correct results in most cases. It is probably due to a better correction for the angle of exposure. This assumption must be verified by more detailed measurements in laboratory conditions.
CALIBRATION OF SILICON DETECTORS LIULIN AND AIRDOS USING COSMIC RAYS AND TIMEPIX FOR USE AT FLIGHT ALTITUDES
Authors: Sommer Marek , Štěpánová Dagmar , Kákona Martin , Velychko Olena , Ambrožová Iva , Ploc Ondřej 
Published: August 2022

Abstract
Silicon detectors such as Liulin and AIRDOS are used for cosmic radiation measurements onboard aircraft. These measurements can be used for the verification of computer programs assessing aircraft crew radiation exposure. Recently performed intercomparison flights showed large variances of absorbed doses among individual detectors and significant differences between results of silicon detectors and computer programs. In order to explain for these differences, we have developed energy calibration method that can be performed on short flights. The method is based on cross-calibration of Liulin and AIRDOS deposited energy spectra with deposited energy spectra measured by Timepix which has superior detection properties in terms of energy resolution and the detection threshold. Moreover, the portion of dose which is omitted due to low sensitivity for low-energy deposits was calculated. The resulting absorbed dose rates at two intercomparison flights show significantly improved variation of results and better agreement with modelled absorbed dose rates.
CHARACTERISATION OF AIRDOS-C DETECTOR FOR MEASUREMENT OF HIGH-ENERGY EVENTS IN THE ATMOSPHERE
Authors: Velychko Olena , Ambrožová Iva , Kákona Martin , Ploc Ondřej 
Published: August 2022

Abstract
At the flight altitudes of modern airplanes, cosmic rays intensity is several times higher than on the Earth’s surface. The radiation field is not constant in time and due to various effects, not routinely considered in calculations, the exposure can increase several times. Therefore, a continuous monitoring of radiation exposure on board is required. This article characterises newly developed detectors Airdos-C with diverse scintillation crystals. Unlike detectors based on a Si diode, which are commonly used for long-term measurements, these detectors can also be used for detection of high-energy gamma-rays generated in thunderstorms. For a correct interpretation of the measured data it is important to perform an energy calibration and to verify the detector response in known radiation fields. The results obtained with several radionuclide sources were analysed using mathematical statistics methods. The detectors were also exposed onboard aircraft under well-defined conditions.
ON UNCERTAINTIES IN THE MANGANESE SULPHATE BATH TECHNIQUES
Authors: Lüley Jakub , Čerba Štefan , Vrban Branislav , Nečas Vladimír 
Published: August 2022

Abstract
The manganese sulphate bath is a globally recognized method for determining emission of neutrons from radionuclide since 1959. In combination with the measurement of neutron emission anisotropy, this method is standardly used for the primary standardization of dosimetry quantities of neutron radiation. To achieve results at the metrology level, it is essential to have all quantities which contribute to the overall uncertainty properly determined and contributing uncertainty minimized. This paper is focused on the quantification of the main uncertainty sources for in-house developed manganese bath. In previous analyses, the final uncertainty of neutron emission rate was &lt;1%, which was considered as a target value. Nevertheless, the relative change from reference values was relatively high and out of this uncertainty. This relative change raised questions about the accuracy of contributed parameters, like vessel volume, concentration of MnSO4 or computational model. Therefore, this paper focuses on determination and re-evaluation of these parameters with corresponding uncertainties.
OSL SENSITIVITY OF QUARTZ EXTRACTED FROM FIRED BRICKS FOR RETROSPECTIVE DOSIMETRY
Authors: Reimitz Dan , Hupka Ivan , Ekendahl Daniela 
Published: August 2022

Abstract
Optically stimulated luminescence of quartz extracted from fired materials has been used for retrospective dosimetry for about 40 years. Quartz sensitivity to thermoluminescence and optically stimulated luminescence can vary over few orders of magnitude. These discrepancies in sensitivity for the quartz originating from different parts of the world are still not yet fully understood. We have extracted quartz from bricks produced by three different companies in the Czech Republic. Quartz was extracted from fired bricks, as well as from the bricks before firing. Significant changes in quartz sensitivity were observed after firing process. Sensitivity can either increase or decrease, depending mainly on the maximum temperature achieved during firing process. For some samples, the sensitivity increased significantly after firing (7 times). Sensitivity also increased after repeated irradiation exposures. On the other hand, there were also samples for which the sensitivity did not increase after repeated cycles of irradiation.
APPARATUS FOR LOCALIZATION AND DOSIMETRY OF WOUNDS WITH RADIOACTIVE CONTAMINATION
Authors: Slavíček Tomáš , Broulím Jan , Fojtík Pavel , Prokop Matěj , Rubovič Peter 
Published: August 2022

Abstract
Disasters involving radioactive materials are one of the most dangerous accidents a living organism can be exposed to. Individuals and first responders are in risk during accidents or interventions, due to radioactive debris impact, due to the use of depleted uranium ammunition or a malevolent act against individuals. Moreover, radioactive contamination of wounds causes internal exposure in the body and standard decontamination procedures cannot be applied. In order to deal with such situations, we are developing a measurement system consisting of a robotic arm, an array of various detectors and a corresponding methodology, which allows quantifying timely the spatial distribution of contamination and the radiation dose for the adequate medical response. The aim of this publication is to the present current status of the development of the described apparatus.
COMPARISON OF THE BACKGROUND GAMMA-RAY SPECTRUM FROM SOIL OBTAINED BY DIRECT MEASUREMENT AND BY CALCULATION USING MCNP6 WITH NAI(TL) SCINTILLATION DETECTOR
Authors: Bednár Dávid , Lištjak Martin , Nečas Vladimír 
Published: August 2022

Abstract
Efficiency calibration is an essential part of any gamma-spectrometric or non-spectrometric measurement. The article describes all steps leading to the reconstruction of the gamma-ray spectrum from the soil — mathematical calibration of the NaI(Tl) detector and optimization of the model in the MCNP6 code, determination of radionuclide vector of soil around NPPs in Slovakia, calculation of the detector response matrix using the calculation code MCNP6 and finally the reconstruction of the gamma-ray spectrum. The results were compared in the energy range of 50–1620 keV for the spectrum obtained by direct measurement of the soil sample and for the spectrum obtained by calculation using the code MCNP6. The relative deviation in the whole spectrum between direct measurement and calculation is not more than 2%, which can be considered as the satisfactory result. The detector model thus created can be used to calculate the response matrix for any geometry arrangement.
RADON-PRONE AREAS IN SLOVAKIA PREDICTED BY RESCALED RADON POTENTIAL MAPS
Authors: Brandýsová Alžbeta , Bulko Martin , Holý Karol , Müllerová Monika , Masarik Jozef 
Published: August 2022

Abstract
Several scientific studies have shown that high content of radon in the soil environment can be a precursor of increased indoor radon levels. Inhabited areas where elevated indoor radon concentration appears for natural (geogenic) reasons are commonly referred to as radon-prone areas. In this study, radon-prone areas in the Slovak Republic were predicted on the basis of radon potential maps after its specific rescaling. In total, 99 municipalities have been identified in Slovakia where the annual average indoor radon concentration is expected to exceed the reference level of 300 Bq m−3; five of those are even expected to exceed 1000 Bq m−3. In these municipalities it is then required to conduct a survey of indoor radon measurements. Compared with a nationwide survey, the proposed approach of searching for houses with potentially high radon exposure is more efficient.
INDOOR RADON MONITORING IN SELECTED BUILDINGS IN VYDRNÍK (VIKARTOVCE FAULT, SLOVAKIA)
Authors: Smetanová Iveta , Mojzeš Andrej , Csicsay Kristian , Marko František 
Published: August 2022

Abstract
To test the relation of indoor radon concentration to fault zone, a survey was conducted in selected buildings in Vydrník, situated close to the neotectonically active Vikartovce fault trace. Monitoring was performed using RamaRn track detectors during a period of 1 year. Annual average of indoor radon ranged from 60 to 940 Bq/m3, with an average of 160 Bq/m3. Seasonal variation of indoor radon concentration was confirmed, with minimum in summer (June–August). The results confirmed that radon concentration in rooms above the cellar was lower than in rooms with the direct contact with subsoil. High indoor radon up to 940 Bq/m3 was detected only in one of monitored houses situated close to the generally E–W trending Vikartovce fault and can be attributed to this fault zone used as pathway for radon migration. Influence of nearby situated NW–SE trending crosscutting fault on radon concentration is probable too.
DOSE RATE MAPPING INSIDE THE STRAZ POD RALSKEM CALIBRATION FACILITY—MONTE CARLO APPROACH
Authors: Johnová Kamila , Klusoň Jaroslav 
Published: August 2022

Abstract
The gamma spectrometry is one of the fundamental methods used in nuclear technology with well-established procedures of data acquisition and evaluation. Yet with expanding possibilities of detection and data processing, the question of accurate calibration very often rises, since the traditional approach to calibration might not always be the most efficient. In our work, we focus on field spectrometry and present a way of utilizing an already established and well working calibration facility and expanding its scope for new types of radiation detectors.