RBC Transfusion in Venovenous Extracorporeal Membrane Oxygenation: A Multicenter Cohort Study
Authors: Raasveld Senta Jorinde , Karami Mina , van den Bergh Walter M. , Oude Lansink-Hartgring Annemieke , van der Velde Franciska , Maas Jacinta J. , van de Berg Pablo , de Haan Maarten , Lorusso Roberto , Delnoij Thijs S. R. , Dos Reis Miranda Dinis , Mandigers Loes , Scholten Erik , Overmars Martijn , Silvio Taccone Fabio , Brasseur Alexandre , Dauwe Dieter F. , De Troy Erwin , Hermans Greet , Meersseman Philippe , Pappalardo Federico , Fominskiy Evgeny , Ivancan Višnja , Bojčić Robert , de Metz Jesse , van den Bogaard Bas , Donker Dirk W. , Meuwese Christiaan L. , de Bakker Martin , Reddi Benjamin , de Bruin Sanne , Lagrand Wim K. , Henriques José P. S. , Broman Lars M. , Vlaar Alexander P. J. 
Published: January 2022

OBJECTIVES:
In the general critical care patient population, restrictive transfusion regimen of RBCs has been shown to be safe and is yet implemented worldwide. However, in patients on venovenous extracorporeal membrane oxygenation, guidelines suggest liberal thresholds, and a clear overview of RBC transfusion practice is lacking. This study aims to create an overview of RBC transfusion in venovenous extracorporeal membrane oxygenation.

DESIGN:
Mixed method approach combining multicenter retrospective study and survey.

SETTING:
Sixteen ICUs worldwide.

PATIENTS:
Patients receiving venovenous extracorporeal membrane oxygenation between January 2018 and July 2019.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
The primary outcome was the proportion receiving RBC, the amount of RBC units given daily and in total. Furthermore, the course of hemoglobin over time during extracorporeal membrane oxygenation was assessed. Demographics, extracorporeal membrane oxygenation characteristics, and patient outcome were collected. Two-hundred eight patients received venovenous extracorporeal membrane oxygenation, 63% male, with an age of 55 years (45–62 yr), mainly for acute respiratory distress syndrome. Extracorporeal membrane oxygenation duration was 9 days (5–14 d). Prior to extracorporeal membrane oxygenation, hemoglobin was 10.8 g/dL (8.9–13.0 g/dL), decreasing to 8.7 g/dL (7.7–9.8 g/dL) during extracorporeal membrane oxygenation. Nadir hemoglobin was lower on days when a transfusion was administered (8.1 g/dL [7.4–9.3 g/dL]). A vast majority of 88% patients received greater than or equal to 1 RBC transfusion, consisting of 1.6 U (1.3–2.3 U) on transfusion days. This high transfusion occurrence rate was also found in nonbleeding patients (81%). Patients with a liberal transfusion threshold (hemoglobin > 9 g/dL) received more RBC in total per transfusion day and extracorporeal membrane oxygenation day. No differences in survival, hemorrhagic and thrombotic complication rates were found between different transfusion thresholds. Also, 28-day mortality was equal in transfused and nontransfused patients.

CONCLUSIONS:
Transfusion of RBC has a high occurrence rate in patients on venovenous extracorporeal membrane oxygenation, even in nonbleeding patients. There is a need for future studies to find optimal transfusion thresholds and triggers in patients on extracorporeal membrane oxygenation.