bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic acids impact bone mineral maturation
Authors: Li Yang , Li Rui , Reid David G. , Lunn Joe T. , Müller Karin H. , Laurencin Danielle , Bonhomme Christian , Ossa E. Alex , Sommerdijk Nico A.J.M. , Duer Melinda J 
Published: September 2022

AbstractBone mineral has a complex 3D architecture that is essential to its mechanical properties. It is a complex calcium phosphate phase related to hydroxyapatite that also contains significant quantities of cell respiration metabolites, in particular: carbonate, citrate and lactate. An as-yet unanswered question is what, if any, role do these metabolites collectively play in determining the 3D architecture of bone mineral? Here we synthesize apatitic materials by transformation from precursor mineral phases containing citrate, lactate or carbonate so that the synthesis environment mimics the densely-packed ionic environment within which bone mineral forms in vivo, and so that we can understand the mineral factors that may direct bone mineral 3D architecture. We show that incorporating citrate and lactate leads to complex mineral architectures reminiscent of those in bone mineral, including curvature of the mineral crystals. Our results suggest that metabolic acids may assist the moulding of bone mineral to restricted spaces available for mineral in in vivo bone. We find that the incorporation of lactate creates a softer material and inhibits the transformation towards apatitic structures, which may help to explain why foetal bone – necessarily soft – contains considerable quantities of lactate. High levels of plasma citrate have been previously found to correlate with high bone mineral density. Here we find that citrate incorporation leads to mineral crystal curvature modelling that in in vivo bone mineral suggesting its importance in mineral morphology. We conclude that metabolic anions may play an important role in controlling bone mineral physicochemical properties and 3D architecture.
The impact of audit committee effectiveness on firms’ outcomes in China: a systematic review
Authors: Komal Bushra , Bilal  , Ye Chengang , Salem Rami 
Published: September 2022

Purpose
This paper aims to discuss the academic literature on the impact of audit committee effectiveness on different outcomes (accounting, auditing, governance and economics) in China.

Design/methodology/approach
The authors have conducted a systematic review using the PRISMA guidelines.

Findings
The key finding is that the regulatory organisations in China, such as the China Securities Regulatory Commission (CSRC) and the State-Owned Assets Supervision and Administration Commission (SASAC), need to play the active role that is expected of them to enhance the transparency and independence of an audit committee. Also, Chinese listed companies are facing institutional barriers (CEO power, concentrated ownership and government influence) to effectively implement the imported concept within China. Research relating to the audit committee's effectiveness has focused mainly on agency and resource dependence perspectives.

Research limitations/implications
China’s regulatory bodies (CSRC and SASAC) should make necessary reforms to enhance the audit committee’s effectiveness. This study also provides implications for the other settings that have imported the audit committee concept from the Anglo-American countries.

Originality/value
This study contributes to the literature by synthesising the prior mixed findings on audit committee literature in China and providing suggestions to the regulators and future research.
Does change in the scoring system impact service evaluation? Evidence from Booking.com
Authors: Kim Jong Min , Liu Jiahao , Yousaf Salman 
Published: September 2022

Purpose
In September 2019, Booking.com changed from the smiley-based scoring system (2.5–10) to the purely 10-point evaluation system (1–10). The smiley-based service evaluation is based on the multi-dimensional (M-D) system, whereas the purely 10-point service evaluation is based on the single-dimensional (S-D) system. This paper aims to focus on how a change in review posting policies impacts service evaluations regarding review generation and distribution.

Design/methodology/approach
The authors exploit the natural experiment using Booking.com when the site changed its scoring system from a multidimensional smiley-based service evaluation system to an S-D scoring system. The authors collected online reviews posted on two travel agencies (Booking.com and Priceline.com) between September 2019 and October 2020. A quasi-experimental approach, Difference-in-Differences, was used to isolate the impacts of the new scoring system from the impacts of the change in the service evaluation environment, i.e. COVID-19.

Findings
The change in the scoring system considerably alters review distributions by decreasing the portion of positive reviews but increasing the portion of highly positive reviews. Using the theory of emotion work (Hochschild, 1979, 2001), DID is also the reason that the former M-D smiley-based system could have underrated, highly positive reviews of services. Using the information transfer theory (Belkin, 1984), the authors reason the asymmetric transfer of information when users consume reviews from the older (M-D) system but are required to generate reviews on a newer (S-D) system.

Practical implications
The findings would provide online review platform management with a deeper understanding of the consequences of changes in service evaluations when the scoring system is changed.

Originality/value
Though the change in the scoring system would affect how customers evaluate the services of hotels, the causal impacts of switching to the new S-D scoring system have not yet been thoroughly covered by prior hospitality and service evaluation literature, which this research aspires to do.
Humble leadership and career success: a moderated mediation analysis
Authors: Chughtai Aamir Ali , Arifeen Shehla R. 
Published: September 2022

PurposeThis study aims to examine the impact of humble leadership on both objective (salary) and subjective (career satisfaction) measures of career success and to investigate the mediating role of innovative work behavior in this relationship. Furthermore, this study also explores the moderating role of affective commitment to the supervisor (ACS) in the relationship between humble leadership and innovative work behavior.Design/methodology/approachSample for this study consisted of 220 employees who were selected from four food and beverage companies based in Pakistan. The research hypotheses were tested through multiple regression analyses, moderated regression analyses and the bootstrapping procedure.FindingsResults showed that innovative work behavior fully mediated the effects of humble leadership on salary, while it partially mediated the effects of humble leadership on career satisfaction. In addition, it was found that ACS moderates the relationship between humble leadership and innovative work behavior such that the relationship is stronger when ACS is high. Finally, results revealed that ACS also moderates the indirect effect of humble leadership on salary and career satisfaction.Originality/valueThis is the first study, which has examined the effects of humble leadership on both objective and subjective measures of career success. In addition, by exploring the mediating role of innovative work behavior and moderating role of ACS, this research sheds light on how and when humble leadership is most effective in facilitating employees' career success.
Locals versus foreigners’ emotion-motivational responses towards traditional and non-traditional food
Authors: Rita Paulo , Arriaga Patrícia , Moura Ana , Guerreiro João 
Published: September 2022

Purpose
The purpose of this paper was to study responses to traditional food of a country, focusing on emotion-motivational responses by locals and foreigners.

Design/methodology/approach
Through an experimental design study, Portuguese and Foreign participants were exposed to both traditional and nontraditional food pictures of a country and asked to evaluate their emotional and motivational responses while physiological responses of electrodermal activity were being continuously recorded. Predisposition factors of body dissatisfaction, food neophobia and food involvement were also evaluated given their potential role in predicting the responses to the visualization of the food pictures.

Findings
This study found that local traditional food received a higher positive evaluation than nontraditional food with locals evaluating it even higher than foreigners. Higher feelings of arousal and desire as well as willingness to try in response to traditional food were also found as well as higher feelings of pleasure by locals. However, interestingly, and contrary to expectations derived from previous literature, emotion-motivational responses were not significantly different between locals and foreigners.

Originality/value
To the best of the authors’ knowledge, this research addressed an identified research gap in the literature, being the first one evaluating the autonomic responses of consumers to traditional food by exploring how local and foreign consumers respond to traditional food versus nontraditional food using psychophysiological measures of emotion.
Regulatory Protection and Opportunistic Bankruptcy*
Authors: Gopalan Radhakrishnan , Martin Xiumin , Srinivasan Kandarp 
Published: September 2022

ABSTRACTWe document controlling shareholder (insider) opportunism in an insolvency regime that uses an accounting rule to determine bankruptcy eligibility. Our study sheds light on managerial incentives induced by weak investor protection laws. Using unique data on bankrupt firms from an emerging market, consistent with our prediction, we show insiders intentionally manage earnings downward to understate firm net worth so as to be able to file for bankruptcy. Downward pre‐bankruptcy earnings management is associated with more payments to insiders and weaker performance, post‐filing. A battery of tests suggests our results cannot be fully explained as an artifact of financial distress. Rather, they are consistent with insiders exploiting weak investor protection to extract private benefits at the expense of lenders and outside shareholders. Our study serves as a cautionary tale for all insolvency regimes that use a balance sheet test in an environment with weak creditor protection.
Polymorphism‐aware estimation of species trees and evolutionary forces from genomic sequences with RevBayes
Authors: Borges Rui , Boussau Bastien , Höhna Sebastian , Pereira Ricardo J. , Kosiol Carolin 
Published: September 2022

Abstract

The availability of population genomic data through new sequencing technologies gives unprecedented opportunities for estimating important evolutionary forces such as genetic drift, selection and mutation biases across organisms. Yet, analytical methods that can handle polymorphisms jointly with sequence divergence across species are rare and not easily accessible to empiricists.

We implemented polymorphism‐aware phylogenetic models (PoMos), an alternative approach for species tree estimation, in the Bayesian phylogenetic software RevBayes. PoMos naturally account for incomplete lineage sorting, which is known to cause difficulties for phylogenetic inference in species radiations, and scale well with genome‐wide data. Simultaneously, PoMos can estimate mutation and selection biases.

We have applied our methods to resolve the complex phylogenetic relationships of a young radiation of Chorthippus grasshoppers, based on coding sequences. In addition to establishing a well‐supported species tree, we found a mutation bias favouring AT alleles and selection bias promoting the fixation of GC alleles, the latter consistent with GC‐biased gene conversion. The selection bias is two orders of magnitude lower than genetic drift, validating the critical role of nearly neutral evolutionary processes in species radiation.

PoMos offer a wide range of models to reconstruct phylogenies and can be easily combined with existing models in RevBayes—for example, relaxed clock and divergence time estimation—offering new insights into the evolutionary processes underlying molecular evolution and, ultimately, species diversification.
Oncological and safety profiles in patients undergoing simultaneous transurethral resection (TUR) of bladder tumour and TUR of the prostate
Authors: Laukhtina Ekaterina , Moschini Marco , Krajewski Wojciech , Teoh Jeremy Yuen‐Chun , Ploussard Guillaume , Soria Francesco , Roghmann Florian , Muenker Mara Anna , Roumiguie Mathieu , Alvarez‐Maestro Mario , Misrai Vincent , Antonelli Alessandro , Tafuri Alessandro , Simone Giuseppe , Mastroianni Riccardo , Zhao Hongda , Rahota Razvan‐George , D'Andrea David , Mori Keiichiro , Albisinni Simone , Karakiewicz Pierre I. , Fajkovic Harun , Enikeev Dmitry , Montorsi Francesco , Shariat Shahrokh F. , Pradere Benjamin ,   the European Association of Urology ‐ Young Academic Urologists (EAU‐YAU): Urothelial Carcinoma Working Group
Published: September 2022

ObjectivesTo determine the oncological impact and adverse events of performing simultaneous transurethral resection of bladder tumour (TURB) and transurethral resection of the prostate (TURP), as evidence on the outcomes of simultaneous TURB for bladder cancer and TURP for obstructive benign prostatic hyperplasia is limited and contradictory.Patients and MethodsPatients from 12 European hospitals treated with either TURB alone or simultaneous TURB and TURP (TURB+TURP) were retrospectively analysed. A propensity score matching (PSM) 1:1 was performed with patients from the TURB+TURP group matched to TURB‐alone patients. Associations between surgery approach with recurrence‐free (RFS) and progression‐free (PFS) survivals were assessed in Cox regression models before and after PSM. We performed a subgroup analysis in patients with risk factors for recurrence (multifocality and/or tumour size >3 cm).ResultsA total of 762 men were included, among whom, 76% (581) underwent a TURB alone and 24% (181) a TURB+TURP. There was no difference in terms of tumour characteristics between the groups. We observed comparable length of stay as well as complication rates including major complications (Clavien–Dindo Grade ≥III) for the TURB‐alone vs TURB+TURP groups, while the latest led to longer operative time (P < 0.001). During a median follow‐up of 44 months, there were more recurrences in the TURB‐alone (47%) compared to the TURB+TURP group (28%; P < 0.001). Interestingly, there were more recurrences at the bladder neck/prostatic fossa in the TURB‐alone group (55% vs 3%, P < 0.001). TURB+TURP procedures were associated with improved RFS (hazard ratio [HR] 0.39, 95% confidence interval [CI] 0.29–0.53; P < 0.001), but not PFS (HR 1.63, 95% CI 0.90–2.98; P = 0.11). Within the PSM cohort of 254 patients, the simultaneous TURB+TURP was still associated with improved RFS (HR 0.33, 95% CI 0.22–0.49; P < 0.001). This was also true in the subgroup of 380 patients with recurrence risk factors (HR 0.41, 95% CI 0.28–0.62; P < 0.001).ConclusionIn our contemporary cohort, simultaneous TURB and TURP seems to be an oncologically safe option that may, even, improve RFS by potentially preventing disease recurrence at the bladder neck and in the prostatic fossa.
Comprehensive review on natural pharmacophore tethered 1,2,3‐triazoles as active pharmaceuticals
Authors: Rammohan Aluru , Venkatesh Bhumireddy Chinnachennaiahgari , Basha Nabhubygari Mahaboob , Zyryanov Grigory V. , Nageswararao Mekala 
Published: September 2022

AbstractThe privileged 1,2,3‐triazole scaffold is drawing researcher's attention due to its widespread applications in diverse fields such as drug discovery (e.g., carboxyamidotriazole), organic synthesis (click‐reaction template), polymeric materials (e.g., triazolamer), supramolecular receptors (e.g., triazolophane), fluorescent materials (e.g., metal–organic frameworks), and agricultural sectors (e.g., fungicides). Various 1,2,3‐triazole persuasion modules are also currently available in the market that have multiple assets such as active pharmaceuticals and agricultural purposes. Owed to the highly consistent and firmest synthesis approach, that is, click reaction of various azides and acetylene derivatives by copper (I)‐catalyzed 1,3‐dipolar cycloaddition (CuAAC), highly functionalized 1,2,3‐triazoles are prepared in scalar yields for drug discovery. Given the importance of 1,2,3‐triazole chemistry, the present review focuses specifically on the synthesis of structurally diverse 1,2,3‐triazoles linked to natural pharmacophores and their biological importance. Furthermore, the dual/multi‐pharmacophores assimilated 1,2,3‐triazoles have listed interesting biological activities that could be valuable as future drug leads. In addition, this comprehensive review can serve as a template for the development of new diverse scaffolds that will ensure for new therapeutic approaches for the existing myriad diseases and disorders.
Trajectories of parent and child well‐being across the pandemic year: Role of financial strain, social distancing, and COVID‐19 prevalence
Authors: Le Yunying , Mogle Jacqueline A. , Feinberg Mark E. 
Published: September 2022

AbstractExisting research demonstrated large deteriorations in parent, child, and family well‐being within 2 months after the onset of the COVID‐19 pandemic. Yet, little is known about the trajectories of families' adjustment in the following months, including what risk factors are associated with changes in families' adjustment. The current study examined (1) change in the parent, child, and family well‐being over time; (2) associations of pandemic‐related stressors, financial and social distancing‐associated stress, with well‐being between and within families; and (3) the role of local COVID‐19 prevalence, prior participation in family‐focused prevention, and parent gender. From April 2020 to January 2021, 393 parents from 235 families reported five times on parent mental health, child behavior problems, family relationships, and pandemic‐related stressors. Findings indicate that, across all domains of well‐being, there was either little change across the 8 months or a small degree of recovery followed by a shift to further deterioration. On average, parents experiencing greater pandemic‐related stressors also reported poorer functioning in all domains; monthly fluctuations in pandemic‐related stressors were also associated with fluctuations in parent mental health and child behavior problems. In some domains, the links between pandemic‐related stressors and parent and child well‐being were stronger among families living in areas with overall higher COVID‐19 prevalence rates. Parents' experiences during the pandemic did not differ systematically across prior intervention participation or parent gender. Taken together, findings suggest a need for supportive interventions to help families navigate extended periods of crisis.
Clinical outcomes of antithrombin III‐based therapy for patients with portal vein thrombosis: A retrospective, multicenter study
Authors: Hayama Korenobu , Atsukawa Masanori , Tsubota Akihito , Kondo Chisa , Iwasa Motoh , Hasegawa Hiroshi , Takaguchi Koichi , Tsutsui Akemi , Uojima Haruki , Hidaka Hisashi , Okubo Hironao , Suzuki Tatsuya , Matsuura Kentaro , Tada Toshifumi , Kawabe Naoto , Tani Joji , Morishita Asahiro , Ishikawa Toru , Arase Yoshitaka , Furuichi Yoshihiro , Kato Keizo , Kawata Kazuhito , Chuma Makoto , Nozaki Akito , Hiraoka Atsushi , Watanabe Tsunamasa , Kagawa Tatehiro , Toyoda Hidenori , Taniai Nobuhiko , Yoshida Hiroshi , Tanaka Yasuhito , Iwakiri Katsuhiko ,   KTK49 Liver Study Group
Published: September 2022

AbstractAimThe association between thrombolytic therapy and the outcome in patients with portal vein thrombosis (PVT) remains controversial. This study aimed to evaluate the outcome in patients with PVT who received antithrombin III‐based therapy.MethodsThis study was a retrospective, multicenter study to investigate the liver‐related events and the survival rates in 240 patients with PVT who received the therapy.ResultsThe patients comprised 151 men and 89 women, with a median age of 69 years. The rate of favorable response, defined as maximum area of PVT changed to ≤75%, was 67.5% (162/240). The cumulative rates of liver‐related events at 1, 2, and 3 years were 38.2%, 53.9%, and 68.5%, respectively. The multivariate analysis showed that viable hepatocellular carcinoma, absence of maintenance therapy, non‐responder, and PVT progression were significantly associated with liver‐related events. The PVT progression was observed in 23.3% (56/240). The multivariate analysis identified older age, absence of maintenance therapy, and non‐responder as independent factors associated with PVT progression. The multivariate analysis revealed that younger age, no hepatocellular carcinoma, presence of maintenance therapy, and lower Model for End‐stage Liver Disease‐Sodium score significantly contributed to 3‐year survival. Of the 240 patients, 13 (8.9%) prematurely discontinued treatment due to any adverse events.ConclusionsThis study suggests that maintenance therapy, favorable response, and absence of PVT progression may suppress or control liver‐related events in antithrombin III‐based therapy for patients with PVT. Specifically, maintenance therapy could suppress not only liver‐related events, but also PVT progression and improve the prognosis.
Using social media for patient and public involvement and engagement in health research: The process and impact of a closed Facebook group
Authors: Fedorowicz Sophia , Riley Victoria , Cowap Lisa , Ellis Naomi J. , Chambers Ruth , Grogan Sarah , Crone Diane , Cottrell Elizabeth , Clark‐Carter David , Roberts Lesley , Gidlow Christopher J. 
Published: September 2022

AbstractBackgroundAs part of a multifaceted approach to patient and public involvement and engagement (PPIE), alongside traditional methods, a closed Facebook group was established to facilitate PPIE feedback on various aspects of a project that used video‐recording to examine risk communication in NHS Health Checks between June 2017 and July 2019.ObjectiveTo explore the process and impact of conducting PPIE through a closed Facebook group and to identify the associated benefits and challenges.MethodsSupported by reflections and information from project meetings used to document how this engagement informed the project, we describe the creation and maintenance of the Facebook Group and how feedback from the group members was obtained. Facebook data were used to investigate levels and types of engagement in the closed Facebook group. We reflect on the challenges of using this method of engaging the public in health research.ResultsA total of 289 people joined the ‘Risk Communication of Cardiovascular disease in NHS Health Checks’ PPIE closed Facebook group. They provided feedback, which was used to inform aspects of the study, including participant‐facing documents, recruitment, camera position and how the methodology being used (video‐recorded Health Checks and follow‐up interviews) would be received by the public.DiscussionUsing a closed Facebook group to facilitate PPIE offered a flexible approach for both researchers and participants, enabled a more inclusive method to PPIE (compared with traditional methods) and allowed rapid feedback. Challenges included maintaining the group, which was more labour intensive than anticipated and managing members' expectations. Suggestions for best practice include clear communication about the purpose of the group, assigning a group co‐ordinator to be the main point of contact for the group, and a research team who can dedicate the time necessary to maintain the group.ConclusionThe use of a closed Facebook group can facilitate effective PPIE. Its flexibility can be beneficial for researchers, patients and public who wish to engage in the research process. Dedicated time for sustained group engagement is important.Patient or Public ContributionPatient representatives were engaged with the development of the research described in this paper and a patient representative reviewed the manuscript.