bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nafion‐multi‐walled Carbon Nanotubes Supported Tris(bipyridyl)iron(II) for Nicotine Detection
Authors: Tiwari Ananya , Yadav Mamta , Kumar Singh Devesh , Ganesan Vellaichamy 
Published: July 2022

AbstractThis work reports an electrochemical sensing framework for nicotine determination based on glassy carbon electrode (GC) immobilized with Fe(bpy)32+(where bpy is 2,2’‐bipyridyl) supported by Nafion and multi‐walled carbon nanotubes (Nf‐MWCNTs). Fe(bpy)32+immobilized Nf‐MWCNTs modified GC (GC/Nf‐MWCNTs/Fe(bpy)32+) manifests stable redox peaks, characteristics of Fe(bpy)32+. The GC/Nf‐MWCNTs/Fe(bpy)32+exhibits effective electrochemical oxidation of nicotine, diminishing the overpotential relative to GC/Nf‐MWCNTs. The limit of detection is 0.1 μM (experimentally observed) with two different linear calibration ranges between 0.1 to 600 μM and 600 to 3000 μM. Electrocatalytic responses observed at GC/Nf‐MWCNTs/Fe(bpy)32+indicate superior performance for nicotine determination with acceptable selectivity, stability, and reproducibility. Additionally, the nicotine present in real samples such as beedi and tobacco are also analyzed with satisfactory recovery percentages.
MiR‐146a‐5p accelerates sepsis through dendritic cell activation and glycolysis via targeting ATG7
Authors: Yu Junbo , Xue Jianhua , Liu Chun , Zhang Aixian , Qin Lili , Liu Jiajia , Yang Yang 
Published: July 2022

AbstractTo unveil the role and regulatory mechanism of miR‐146a‐5p in sepsis. A sepsis cell model was established via lipopolysaccharide (LPS)‐induction in dendritic cells (DCs). The maturation of DCs was evaluated via flow cytometry. Gene expression was measured through reverse‐transcription quantitative polymerase chain reaction (RT‐qPCR). The concentrations of inflammation biomarkers were revealed via enzyme‐linked immunosorbent assay (ELISA). The pathological and histological changes in lungs in the sepsis mice model were analyzed via hematoxylin and eosin (H&E) staining. In this study, the miR‐146a‐5p level was elevated in the serum of sepsis patients and LPS‐induced DCs but decreased in the serums of cured sepsis patients. Furthermore, miR‐146a‐5p deletion alleviated the activation of T cells and attenuated the imbalance of Th17/Treg. Besides, ATG7 was validated as a target of miR‐146a‐5p. ATG7 elevation enhanced lactate production and glucose uptake in LPS‐triggered DCs. Additionally, upregulation of ATG7 suppressed the protein levels of phosphorylated adenosine monophosphate‐activated protein kinase (p‐AMPK), phospho protein kinase B (p‐AKT), and phosphorylated signal transducer and activator for transcription 3 (p‐STAT3). In addition, miR‐146a‐5p downregulation alleviated T‐cell activation, inflammation, lactate production, and glucose uptake in sepsis mice. Moreover, the lung injury due to sepsis was also attenuated as a result of miR‐146a‐5p silencing. MiR‐146a‐5p aggravates sepsis through DCs activation and glycolysis via targeting ATG7.
Study of the electrostatic repulsion of the carboxylic surface in the diffusion layer by scanning electrochemical microscopy
Authors: Li Xia , Li Na , Chen Zhuangzhuang , Shao Huibo 
Published: July 2022

AbstractThe behavior of electrostatic repulsion in the diffusion layer on the electrode is significant for understanding electrochemical processes with a diffusion control step. In this work, the electrostatic repulsion at the carboxylic acid‐containing surface of a 3‐mercaptopropionic acid self‐assembled monolayer (MPA SAM) in the diffusion layer on the tip electrode was revealed by scanning electrochemical microscopy (SECM). A direct surface repulsion system was designed between [Fe(CN)6]4− and the carboxylate groups in the diffusion layer. The pH‐modulated electrostatic repulsion of the carboxylic surface led to the repulsion of [Fe(CN)6]4− during diffusion, interrupting the regeneration of [Fe(CN)6]4− to [Fe(CN)6]3− on MPA SAM. Therefore, the approaching curve underwent a characteristic inversion from positive feedback to negative feedback dramatically. Electrostatic repulsion of the carboxylic surface was confirmed by linear sweep voltammetry and substrate generation/tip collection. Furthermore, the electrostatic repulsion of the carboxylic surface was visualized by SECM imaging technology. This work has contributed to broadening the recognition of electrostatic repulsion in the diffusion layer.
Solvent polarity‐dependent ESIPT behavior for 5‐(benzothiazole‐2‐yl)‐4‐hydroxyisophthalaldehyde fluorophore: A theoretical study
Authors: Guan Yanlong , Tang Zhe , Ju Liping , Zhao Jinfeng 
Published: July 2022

AbstractIn view of the potential applications of 5‐(benzothiazole‐2‐yl)‐4‐hydroxyisophthalaldehyde (BHI) in the rapid identification of cyanide, the mechanism of excited‐state intramolecular proton transfer (ESIPT) of BHI has been studied in this work. By exploring the geometric parameters of hydrogen bonding in aprotic solvents with different polarities, infrared (IR) vibrational spectroscopy can confirm that hydrogen bonding is enhanced in the first excited state (S1). It is worth mentioning that the enhancement of hydrogen bonding in the S1 state by polar solvents is particularly important. In light‐induced excitation, by comparing the energy gaps of the leading molecular orbitals and the charge recombination around the proton acceptor and donor in aprotic solvents of different polarities, it is further predicted that polar solvents can promote the ESIPT process of BHI. In order to clarify the detailed ESIPT mechanism, we constructed the potential energy curves, searched for the transition state (TS) form, and determined the ESIPT mechanism for BHI fluorophore. Herein, we not only elucidated the excited‐state behavior of BHI, but also proposed a mechanism for regulating ESIPT by solvent polarity.
Motor cortical plasticity in adolescents with early onset schizophrenia: A TMS‐EMG study assessing the perturbation effect of intermittent and continuous theta burst stimulation
Authors: Purushotham Ashwathnarayan , Goyal Nishant , Sinha Vinod Kumar , Tikka Sai Krishna , Garg Shobit , Desarkar Pushpal 
Published: July 2022

AbstractBackgroundNeuroplasticity in adolescents is distinct from that of adults. Literature pertaining to neuroplasticity in schizophrenia is limited to adult populations.AimWe aimed to assess baseline (or resting) cortical excitability and cortical plasticity in adolescents with schizophrenia using the transcranial magnetic stimulation‐electromyography (TMS‐EMG) protocol.MethodsTwenty adolescent cases with schizophrenia and 20 age and gender matched healthy controls were studied using a crossover design. Single pulse TMS elicited resting motor threshold (RMT) and motor evoked potentials (MEPs) were assessed. Cortical plasticity was determined by tracking MEPs after a single session continuous theta burst stimulation (cTBS) and intermittent theta burst stimulation (iTBS) up to 120 min at 12 intervals.ResultsBaseline (or resting) cortical excitability was found to be significantly lower in cases compared with controls. Response patterns to cTBS and iTBS were similar between the crossover. While cTBS led to inhibitory response, iTBS had an excitatory effect in both the groups. In the cases, while cTBS led to significantly greater initial inhibitory response, iTBS led to significantly lower excitatory response, compared with controls. The time taken to return to baseline excitability was significantly longer after receiving cTBS for cases, compared with controls.ConclusionsiTBS and cTBS lead to excitatory and inhibitory response, representing classical long‐term depression and long‐term potentiation effects, respectively, in both cases and controls. We conclude that adolescents with schizophrenia have significantly lower baseline (resting) cortical excitability as well as significantly greater inhibitory plasticity; excitatory plasticity is significantly lower.
Time‐series gene expression patterns and their characteristics of Beauveria bassiana in the process of infecting pest insects
Authors: Zhang Guochao , Zhang Jifeng , Yao Zhuo , Shi Yong , Xu Chenxi , Shao Lvyi , Jiang Lei , Li Maoye , Tong Yue , Wang Yujun 
Published: July 2022

AbstractBeauveria bassiana has been widely used as an important biological control fungus for agricultural and forest pests, and clarifying the interaction mechanism between B. bassiana and its host will help to better exert the efficacy of the mycoinsecticide. Here, we proposed a novel pattern analysis (PA) method for analyzing time‐series data and applied it to a transcriptomic data set of B. bassiana infecting Galleria mellonella. We screened out 14 patterns including 868 genes, which had some characteristics that were not inferior to differentially expressed genes (DEGs). Compared with the previous analysis of this data set, we had three novel discoveries during B. bassiana infection, including overall downregulation of gene expression, the more critical first 24 h, and enrichment of regulatory functions of downregulated genes. Our new PA method promises to be an important complement to DEGs analysis for time‐series transcriptomic data, and our findings enrich our knowledge of molecular mechanisms of fungal–host interactions.
Analysis of changes in large‐scale circulation patterns driving extreme precipitation events over the central‐eastern China
Authors: Jiang Qin , Cioffi Francesco , Giannini Mario , Wang Jun , Li Weiyue 
Published: July 2022

AbstractTo an extent, large‐scale circulation situations and moisture transport are responsible for extreme precipitation occurrence. The aim of our study is to investigate the possible modifications of circulation patterns (CPs) in driving extreme precipitation over the central‐eastern China (CEC). The self‐organizing map (SOM) and event synchronization methods are used to link the extreme precipitation events with CPs. Results show that 23% of rain gauges have a significant change point (at the 90% confidence level) in annual extreme precipitation from 1960 to 2015. Based on the identified change points, we classified the data into two periods, that is, 1960–1989 and 1990–2015. Overall, CPs characterized by obvious positive anomalies of 500 hPa geopotential height over the Eastern Eurasia continent and negative values over the surrounding oceans are highly synchronized with extreme precipitation events. During 1990–2015, the predominant CPs are more related to the extreme precipitation with enhanced event synchronization. We found that the CP changes produce an increase in extreme precipitation frequency from 1960–1989 to 1990–2015.
Bioactive antioxidant coatings for poly(lactic acid) packaging films: polyphenols affect coating structure and their release in a food simulant
Authors: Benbettaieb Nasreddine , Mlaouah Emna , Moundanga Sylvie , Brachais Claire‐Hélène , Kurek Mia , Galić Kata , Debeaufort Frédéric 
Published: July 2022

AbstractBACKGROUNDPoly(lactic acid) (PLA) has limited uses for moist and acidic foods due to its barrier properties, which are fairly poor, and its sensitivity to moisture.RESULTSDeposition of thin coatings based on natural biopolymers (gelatin) incorporating bioactive agents has allowed the development of active packaging materials while maintaining their biodegradability and their food contact material ability. Gelatin coatings containing two phenolic acids (tannic and gallic) have been tested. These coated PLA films displayed a reduction of the moisture permeability and a slight modification of the thermal properties of PLA. The antioxidant properties of the films and their release kinetics in a simulant medium have been studied and modelled.CONCLUSIONSIncorporation of phenolic acids induced interactions with the gelatin that modified the structure of the network and positively affected the retention, diffusivity, and transfer rate of the bioactive compounds when coated PLA films were in contact with the liquid simulant. © 2022 Society of Chemical Industry.
Soil mite communities structure (Acari, Mesostigmata) during litter decomposition of seven tree species in pure Scots pine stands (Pinus sylvestrisL.) growing on a reclaimed post‐industrial area
Authors: Urbanowski Cezary K. , Horodecki Paweł , Kamczyc Jacek , Skorupski Maciej , Jagodziński Andrzej M. 
Published: July 2022

AbstractOur knowledge about mites, including mesostigmatids, compared to their significant role in soil‐forming processes on post‐industrial areas, is currently insufficient. Therefore, our study aim was to analyze the succession of mesostigmatid communities in relation to litter decomposition of seven tree species [Acer pseudoplatanusL.,Alnus glutinosa(L.) Gaertn.,Fagus sylvaticaL.,Pinus sylvestrisL.,Prunus serotinaEhrh.,Quercus rubraL.,Robinia pseudoacaciaL.] in pure Scots pine stands growing on a reclaimed spoil heap. In December 2011, 1439 litterbags were placed on plots and collected after ca. 3, 6, 9, 13, 19, 25, 31, 37 months since the experiment started. In total, we recorded 9653 mites classified into 67 taxa. The mesostigmatid abundance was affected by percentage initial litter mass loss. Interestingly, litter type shaped species richness and diversity, but not abundance. The highest abundance, almost two‐times higher compared to other tree species, was recorded inPrunus serotinalitter (352.73 ± 105.22 ind.; calculated per 100 g of dry litter mass) and the lowest inQuercus rubra(81.23 ± 9.82 ind.). Furthermore, the lowest richness (2.39 ± 0.07; calculated per sample) and diversity (0.33 ± 0.02; calculated per sample) was recorded inPinus sylvestrislitter, therefore, our results are in contradiction to the home‐field advantage assumptions that the ‘home’ litter has a positive effect on soil fauna structure compared to the ‘foreign’ litter. Nevertheless, the greatest abundance share ofAsca bicornisandAmblyseius tubae, the most numerous species, was recorded forPinus sylvestrislitter.
ERO1L promotes the proliferation and metastasis of lung adenocarcinoma via the Wnt2/β‐catenin signaling pathway
Authors: Xie Jinbao , Liao Guoliang , Feng Zhi , Liu Bo , Li Xu , Qiu Minglian 
Published: July 2022

AbstractPurposeThis study aimed to explore the role and underlying mechanism of action of Endoplasmic reticulum oxidoreductin‐1 L (ERO1L) in lung adenocarcinoma (LUAD).Materials and MethodsThe Gene expression profiling interactive analysis database was used to analyze the expression of ERO1L in LUAD cases. The expression of ERO1L and Wnt2 in LUAD tissue was evaluated using immunohistochemistry. We also used western blotting to assess the expression of ERO1L or Wnt2 and the phosphorylation of β‐catenin in LUAD cell lines. Plasmid transfection and small interfering RNA were used for overexpression and knockdown of ERO1L in LUAD cells, respectively. The proliferation, invasion and migration of LUAD cells were analyzed using cell viability, Transwell invasion and wound healing assays. The growth of LUAD tumors in animal models was assessed using tumor xenograft experiments.ResultsThis study revealed that elevated ERO1L expression was associated with a poor prognosis in LUAD patients. In addition, ERO1L expression was significantly associated with lymph‐node metastasis, TNM stage and tumor size. The expression of Wnt2 was positively associated with ERO1L expression in LUAD tissue samples and cell lines. ERO1L overexpression upregulated the expression of Wnt2 and β‐catenin phosphorylation in vitro. Additionally, ERO1L was essential for the ubiquitination of Wnt2. Last, ERO1L promoted the proliferation and metastasis of LUAD via the Wnt2 signaling pathway in vitro and in vivo.ConclusionThese findings suggest that ERO1L was highly expressed in LUAD tissue, and it promoted the proliferation and metastasis of LUAD by activating the Wnt2/β‐catenin signaling pathway.
Ultrahigh Resolution fMRI at 7T Using Radial‐Cartesian TURBINE Sampling
Authors: Graedel Nadine N. , Miller Karla L. , Chiew Mark 
Published: July 2022

PurposeWe investigate the use of TURBINE, a 3D radial‐Cartesian acquisition scheme in which EPI planes are rotated about the phase‐encoding axis to acquire a cylindrical k‐space for high‐fidelity ultrahigh isotropic resolution fMRI at 7 Tesla with minimal distortion and blurring.MethodsAn improved, completely self‐navigated version of the TURBINE sampling scheme was designed for fMRI at 7 Telsa. To demonstrate the image quality and spatial specificity of the acquisition, thin‐slab visual and motor BOLD fMRI at 0.67 mm isotropic resolution (16 mm slab, TRvol = 2.32 s), and 0.8 × 0.8 × 2.0 mm (whole‐brain, TRvol = 2.4 s) data were acquired. To prioritize the high spatial fidelity, we employed a temporally regularized reconstruction to improve sensitivity without any spatial bias.ResultsTURBINE images provide high structural fidelity with almost no distortion, dropout, or T2* blurring for the thin‐slab acquisitions compared to conventional 3D EPI owing to the radial sampling in‐plane and the short echo train used. This results in activation that can be localized to pre‐ and postcentral gyri in a motor task, for example, with excellent correspondence to brain structure measured by a T1‐MPRAGE. The benefits of TURBINE (low distortion, dropout, blurring) are reduced for the whole‐brain acquisition due to the longer EPI train. We demonstrate robust BOLD activation at 0.67 mm isotropic resolution (thin‐slab) and also anisotropic 0.8 × 0.8 × 2.0 mm (whole‐brain) acquisitions.ConclusionTURBINE is a promising acquisition approach for high‐resolution, minimally distorted fMRI at 7 Tesla and could be particularly useful for fMRI in areas of high B0 inhomogeneity.
Two cases of acute respiratory failure following SARS‐CoV‐2 vaccination in post‐COVID‐19 pneumonia
Authors: Bando Tomohiro , Takei Reoto , Mutoh Yoshikazu , Sasano Hajime , Yamano Yasuhiko , Yokoyama Toshiki , Matsuda Toshiaki , Kataoka Kensuke , Kimura Tomoki , Kondoh Yasuhiro 
Published: July 2022

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccination is a very effective method of preventing infection and is recommended for people having recovered from coronavirus disease 2019 (COVID‐19). In this novel case report, we describe two patients with post‐COVID‐19 pneumonia who experienced acute respiratory failure and new bilateral ground‐glass opacities several days after receiving SARS‐CoV‐2 vaccination. Both patients were treated with methylprednisolone pulse therapy and recovered from the disease successfully. Indeed, post‐COVID‐19 patients can gain benefits from the vaccine, but vaccination at the early stage of recovery from COVID‐19 might be a risk for certain populations. These cases highlight a potential association between vaccination, interstitial lung disease and worsening of post‐COVID‐19 pneumonia. Further investigation and research examining the relationship between the timing of SARS‐CoV‐2 vaccination and potential risks in post‐COVID‐19 patients is recommended.
Learning outcomes of university chemistry teaching in laboratories: A systematic review of empirical literature
Authors: Agustian Hendra Y. , Finne Laura Teinholt , Jørgensen Jonas Tarp , Pedersen Maja Ingerslev , Christiansen Frederik Voetmann , Gammelgaard Bente , Nielsen Jan Alexis 
Published: July 2022

AbstractLaboratory work has been a common element of science courses at university level for around two centuries, but its practice has been criticised by scholars in the field and related stakeholders. Mainly on a rationale of financial justification and educational efficacy, more evidence for learning has been called for. The aims of this systematic review were to characterise learning in the laboratory and substantiate learning outcomes associated with laboratory instructions in university chemistry. Analysis of 355 empirical studies revealed that students develop five clusters of laboratory‐related competences pertaining to experimental competences, disciplinary learning, higher‐order thinking and epistemic learning, transversal competences as well as affective domain. These competences were specified into related constructs measured in the studies. Synthesis of published studies led to a substantiated view on multidimensional learning in the laboratory and its implications for research, practice and theory are suggested. Representations of research areas that deserve appraisals and further investigations are also proposed. The video abstract for this article is available at https://video.ku.dk/secret/76185334/73665cb966315601404b793ffc234a77.
Context and implicationsRationale for this studyTo provide comprehensive evidence for learning outcomes associated with laboratory work.Why the new findings matterOur research synthesis substantiates a multidimensional view of laboratory learning. There is a large scope for empirical and theoretical development in this complex setting.Implications for researchers and practitionersFuture research should be directed towards a more comprehensive and rigorous inquiry into student learning that considers a more holistic view. Focus on higher‐order competences is needed. Practice wise, laboratory curricula should better accommodate students' learning progression throughout their higher education. Assessment and feedback practices should be revisited.
Aprotic Lithium‐Carbon Dioxide Batteries: Reaction Mechanism and Catalyst Design
Authors: Xu Yunyun , Xia Yujiao , Xue Hairong , Gong Hao , Chang Kun , He Jianping , Wang Tao , Ma Renzhi 
Published: July 2022

AbstractIn recent years, the combustion of fossil fuels leads to the release of a large amount of CO2 gas, which induces the greenhouse effect and the energy crisis. To solve these problems, researchers have turned their focus to a novel Li‐CO2 battery (LCB). LCB has received much attention because of its high theoretical energy density and reversible CO2 reduction/evolution process. So far, the emerging LCB still faces many challenges derived from the slow reaction kinetics of discharge products. In this review, the latest status and progress of LCB, especially the influence of the structure design of cathode catalysts on the battery performance, are systematically elaborated. This review summarizes in detail the existing issues and possible solutions of LCB, which is of high research value for further promoting the development of Li‐Air battery.
A Review on the Prediction of Health State and Serving Life of Lithium‐Ion Batteries
Authors: Pang Xiaoxian , Zhong Shi , Wang Yali , Yang Wei , Zheng Wenzhi , Sun Gengzhi 
Published: July 2022

AbstractThe monitoring and prediction of the health status and the end of life of batteries during the actual operation plays a key role in the battery safety management. However, although many related studies have achieved exciting results, there are few systematic and comprehensive reviews on these prediction methods. In this paper, the current prediction models of remaining useful life of lithium‐ion batteries are divided into mechanism‐based models, semi‐empirical models and data‐driven models. Their advantages, technical obstacles, improvement methods and prediction performance are summarized, and the latest research results are shown by comparison. We highlight that the fusion models of convolution neural network, long short term memory network and so on, which have great practical application prospects because of their outstanding computing efficiency and strong modeling ability. Finally, we look forward to the future work in simplifying the model and improving its interpretability.