bluuebunny/crossref_metadata_2025_split huggingface dataset:
ACHINOS: a multi-anode read-out for position reconstruction and tracking with spherical proportional counters
Authors: Katsioulas I. , Knights P. , Manthos I. , Matthews J. , Neep T. , Nikolopoulos K. , Ward R. 
Published: August 2022

Abstract
The spherical proportional counter is a versatile gaseous detector with physics applications ranging from rare event searches to fast neutron spectroscopy. In its simplest form, the detector operates with a single channel read-out, and uses pulse-shape information to reconstruct the interaction radius, which is used for background discrimination and target volume definition. Recent developments in the read-out instrumentation have enabled the use of a multi-anode read-out structure, ACHINOS. The multiple anodes provide information about the interaction position which, coupled with the radial information, can be used to reconstruct an ionisation track. This ability has implications for several applications of the detector, for example, enhanced background discrimination in rare event searches.
Precision antihydrogen annihilation reconstructions using the ALPHA-g detector
Authors: Woosaree Pooja 
Published: August 2022

Abstract
The ALPHA (Antihydrogen Laser PHysics Apparatus) collaboration aims to test fundamental symmetries with matter and antimatter by testing CPT (charge conjugation, parity reversal, time reversal) theory and observing whether antimatter follows Einstein’s Weak Equivalence Principle (WEP), where the acceleration due to gravity that a body experiences is independent of its structure or composition. A measurement of the gravitational mass of antimatter has never been done before, as previous experiments used charged particles, which meant the experiments were dominated by electromagnetic forces. The ALPHA-g apparatus will use electrically neutral antihydrogen atoms produced in a vertical Penning-Malmberg trap and hold the antihydrogen in a magnetic well. Once the antihydrogen is released, the position of the resulting annihilations can be reconstructed with a radial time projection chamber (rTPC) surrounding the trapping volume. Tracing the annihilation position within the rTPC is imperative to measuring the gravitational mass of antihydrogen. These proceedings will highlight simulations of antihydrogen annihilations, and how to calibrate the detector for z-positions. This data will be used to measure the gravitational mass of antihydrogen; an important measurement in testing the fundamental symmetry of matter and antimatter. The ALPHA-g apparatus is currently being commissioned at CERN, and the first gravitational measurements of antihydrogen are underway.
Live fish learn to anticipate the movement of a fish-like robot
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Authors: Bierbach David , Gómez-Nava Luis , Francisco Fritz A , Lukas Juliane , Musiolek Lea , Hafner Verena V , Landgraf Tim , Romanczuk Pawel , Krause Jens 
Published: August 2022

Abstract
The ability of an individual to predict the outcome of the actions of others and to change their own behavior adaptively is called anticipation. There are many examples from mammalian species—including humans—that show anticipatory abilities in a social context, however, it is not clear to what extent fishes can anticipate the actions of their interaction partners or what the underlying mechanisms are for that anticipation. To answer these questions, we let live guppies (Poecilia reticulata) interact repeatedly with an open-loop (noninteractive) biomimetic robot that has previously been shown to be an accepted conspecific. The robot always performed the same zigzag trajectory in the experimental tank that ended in one of the corners, giving the live fish the opportunity to learn both the location of the final destination as well as the specific turning movement of the robot over three consecutive trials. The live fish’s reactions were categorized into a global anticipation, which we defined as relative time to reach the robot’s final corner, and a local anticipation which was the relative time and location of the live fish’s turns relative to robofish turns. As a proxy for global anticipation, we found that live fish in the last trial reached the robot’s destination corner significantly earlier than the robot. Overall, more than 50% of all fish arrived at the destination before the robot. This is more than a random walk model would predict and significantly more compared to all other equidistant, yet unvisited, corners. As a proxy for local anticipation, we found fish change their turning behavior in response to the robot over the course of the trials. Initially, the fish would turn after the robot, which was reversed in the end, as they began to turn slightly before the robot in the final trial. Our results indicate that live fish are able to anticipate predictably behaving social partners both in regard to final movement locations as well as movement dynamics. Given that fish have been found to exhibit consistent behavioral differences, anticipation in fish could have evolved as a mechanism to adapt to different social interaction partners.
Thrust and torque production of a squid-inspired swimmer with a bent nozzle for thrust vectoring
Authors: Luo Yang , Xiao Qing , Zhu Qiang , Pan Guang 
Published: August 2022

Abstract
A three-dimensional pulsed-jet propulsion model consisting of a flexible body and a steerable bent nozzle in tethered mode is presented and studied numerically. By prescribing the body deformation and nozzle angle, we examine the flow evolution and propulsive/turning performance via thrust vectoring. Our results show that the vortex ring is no longer axis-symmetric when the jet is ejected at an angle with the incoming flow. A torque peak is observed during jetting, which is mainly sourced from the suction force (negative pressure) at the lower part of the internal nozzle surface when the flow is directed downward through an acute angle. After this crest, the torque is dominated by the positive pressure at the upper part of the internal nozzle surface, especially at a relatively low jet-based Reynolds number (O(102)). The torque production increases with a larger nozzle bent angle as expected. Meanwhile, the thrust production remains almost unchanged, showing little trade-off between thrust and torque production which demonstrates the advantage of thrust vectoring via a bent nozzle. By decoupling the thrust at the internal and outer surfaces considering special characteristics of force generation by pulsed-jet propulsion, we find that variations in Reynolds number mostly affect the viscous friction at the outer surfaces. The influence of the maximum stroke ratio is also studied. Results show that both the time-averaged thrust and the torque decrease at a larger stroke ratio.
Modeling the musculoskeletal system of an insect thorax for flapping flight
Authors: Ando Noriyasu , Kono Tokuro , Ogihara Naomichi , Nakamura Sakiko , Yokota Hideo , Kanzaki Ryohei 
Published: August 2022

Abstract
Indirect actuation of the wings via thoracic deformation is a unique mechanism widely observed in flying insect species. The physical properties of the thorax have been intensively studied in terms of their ability to efficiently generate wingbeats. The basic mechanism of indirect wing actuation is generally explained as a lever model on a cross-sectional plane, where the dorsoventral movement of the mesonotum (dorsal exoskeleton of the mesothorax) generated by contractions of indirect muscles actuates the wing. However, the model considers the mesonotum as an ideal flat plane, whereas the mesonotum is hemispherical and becomes locally deformed during flight. Furthermore, the conventional model is two-dimensional; therefore, three-dimensional wing kinematics by indirect muscles have not been studied to date. In this study, we develop structural models of the mesonotum and mesothorax of the hawkmoth Agrius convolvuli, reconstructed from serial cross-sectional images. External forces are applied to the models to mimic muscle contraction, and mesonotum deformation and wing trajectories are analyzed using finite element analysis. We find that applying longitudinal strain to the mesonotum to mimic strain by depressor muscle contraction reproduces local deformation comparable to that of the thorax during flight. Furthermore, the phase difference of the forces applied to the depressor and elevator muscles changes the wing trajectory from a figure eight to a circle, which is qualitatively consistent with the tethered flight experiment. These results indicate that the local deformation of the mesonotum due to its morphology and the thoracic deformation via indirect power muscles can modulate three-dimensional wing trajectories.
Independent control of molecular weight, concentration, and stiffness of hyaluronic acid hydrogels
Authors: Townsend Jakob M , Sanders Megan E , Kiyotake Emi A , Detamore Michael S 
Published: August 2022

Abstract
Hyaluronic acid (HA) hydrogels have been used for a multitude of applications, perhaps most notably for tissue engineering and regenerative medicine, owing to the versatility of the polymer and its tunable nature. Various groups have investigated the impact of hydrogel parameters (e.g. molecular weight, concentration, stiffness, etc) in vitro and in vivo to achieve desired material performance characteristics. A limitation in the literature to date has been that altering one hydrogel parameter (a ‘manipulated variable’) to achieve a given hydrogel characteristic (a ‘controlled variable’) changes two variables at a time (e.g. altering molecular weight and/or concentration to investigate cell response to stiffness). Therefore, if cell responses differ, it may be possible that more than one variable caused the changes in observed responses. In the current study, we leveraged thiol-ene click chemistry with a crosslinker to develop a method that minimizes material performance changes and permitted multiple material properties to be independently held constant to evaluate a single variable at a time. Independent control was accomplished by tuning the concentration of crosslinker to achieve an effectively constant stiffness for different HA hydrogel molecular weights and polymer concentrations. Specific formulations were thereby identified that enabled the molecular weight (76–1550 kDa), concentration (2%–10%), or stiffness (∼1–350 kPa) to be varied while the other two were held constant, a key technical achievement. The response of rat mesenchymal stem cells to varying molecular weight, concentration, and stiffness demonstrated consistent upregulation of osteocalcin gene expression. The methodology presented to achieve independent control of hydrogel parameters may potentially be adopted by others for alternative hydrogel polymers, cell types, or cell culture medium compositions to minimize confounding variables in experimental hydrogel designs.
Projected changes in early summer ridging and drought over the Central Plains
Authors: Cook Benjamin I , Williams A Park , Marvel Kate 
Published: August 2022

Abstract
Early summer (May–June–July; MJJ) droughts over the Central Plains are often caused by atmospheric ridging, but it is uncertain if these events will increase in frequency or if their influence on drought severity will change in a warming world. Here, we use tree-ring based reconstructions (1500–2020 CE) of MJJ ridging and 0–200 cm soil moisture with six CMIP6 model ensembles to investigate the response of Central Plains drought dynamics to a moderate warming scenario (SSP2-4.5). By the end of the 21st century (2071–2100), precipitation increases in most models during the preceding months (February–March–April), especially over the northern part of the Central Plains, while changes during MJJ are non-robust. By contrast, vapor pressure deficit increases strongly in all models, resulting in five of the six models projecting robust median soil moisture drying and all six models projecting more rapid seasonal soil moisture declines during the transition into the summer. Major ridging events increase in frequency in some models, and there is strong agreement across all models that when ridging events do occur, they will cause more severe soil moisture drought and seasonal drying at the end of the 21st century. The median multi-model response also indicates, by the end of the 21st century, that the Central Plains will experience a three-fold increase in the risk of drought events equivalent to the most extreme droughts of the last 500 years. Our results demonstrate that even moderate warming is likely to increase early summer soil moisture drought severity and risk over the Central Plains, even in the absence of robust precipitation declines, and that drought responses to major atmospheric ridging events will be significantly stronger.
Proton acceleration from picosecond-laser interaction with a hydrocarbon target
Authors: YANG Yuchen , HUANG Taiwu , JIANG Ke , YU Mingyang , ZHOU Cangtao 
Published: August 2022

Abstract
As an intense picosecond laser pulse irradiates a hydrocarbon target, the protons therein can be accelerated by the radiation pressure as well as the sheath field behind the target. We investigate the effect of the laser and hydrocarbon target parameters on proton acceleration with two/three-dimensional particle-in-cell simulations. It is found that the resulting two-ion species plasma can generate a multiple peaked charge-separation field that accelerates the protons. In particular, a smaller carbon-to-hydrogen ratio, as well as the thinner and/or lower density of the target, leads to a larger sheath field and thus proton beams with a larger cutoff energy and smoother energy spectrum. These results may be useful in achieving high-flux quasi-monoenergetic proton beams by properly designing the hydrocarbon target.
Experimental studies of cusp stabilization in Keda Mirror with AXisymmetricity (KMAX)
Authors: LI Qing , ZHU Guanghui , REN Baoming , YING Jiacheng , YANG Zhida , SUN Xuan 
Published: August 2022

Abstract
Stabilization of the axisymmetric magnetic mirror relies on the pressure-weighted magnetic field curvature. We report a new experiment by configuring a magnetic cusp structure to stabilize m = 1 interchange mode in the KMAX tandem mirror. The cusp configuration is formed by reversing currents in the two side cell coils, and a stronger cusp can lead to a more stable plasma once the null point of the cusp is less than 35–40 cm away from the device axis. The density fluctuations measured by four axial Langmuir probes are mitigated by 70%–80%. The stabilization effect is consistent with the prediction of a theoretical calculation.
IgIDivA: immunoglobulin intraclonal diversification analysis
Authors: Zaragoza-Infante Laura , Junet Valentin , Pechlivanis Nikos , Fragkouli Styliani-Christina , Amprachamian Serovpe , Koletsa Triantafyllia , Chatzidimitriou Anastasia , Papaioannou Maria , Stamatopoulos Kostas , Agathangelidis Andreas , Psomopoulos Fotis 
Published: August 2022

AbstractIntraclonal diversification (ID) within the immunoglobulin (IG) genes expressed by B cell clones arises due to ongoing somatic hypermutation (SHM) in a context of continuous interactions with antigen(s). Defining the nature and order of appearance of SHMs in the IG genes can assist in improved understanding of the ID process, shedding light into the ontogeny and evolution of B cell clones in health and disease. Such endeavor is empowered thanks to the introduction of high-throughput sequencing in the study of IG gene repertoires. However, few existing tools allow the identification, quantification and characterization of SHMs related to ID, all of which have limitations in their analysis, highlighting the need for developing a purpose-built tool for the comprehensive analysis of the ID process. In this work, we present the immunoglobulin intraclonal diversification analysis (IgIDivA) tool, a novel methodology for the in-depth qualitative and quantitative analysis of the ID process from high-throughput sequencing data. IgIDivA identifies and characterizes SHMs that occur within the variable domain of the rearranged IG genes and studies in detail the connections between identified SHMs, establishing mutational pathways. Moreover, it combines established and new graph-based metrics for the objective determination of ID level, combined with statistical analysis for the comparison of ID level features for different groups of samples. Of importance, IgIDivA also provides detailed visualizations of ID through the generation of purpose-built graph networks. Beyond the method design, IgIDivA has been also implemented as an R Shiny web application. IgIDivA is freely available at https://bio.tools/igidiva
Clinical event reductions in high-risk patients after renal denervation projected from the global SYMPLICITY registry
Authors: Schmieder Roland E , Mahfoud Felix , Mancia Giuseppe , Narkiewicz Krzysztof , Ruilope Luis , Hutton David W , Cao Khoa N , Hettrick Douglas A , Fahy Martin , Schlaich Markus P , Böhm Michael , Pietzsch Jan B 
Published: August 2022

Abstract

Aims
Renal denervation has been shown to lower blood pressure in sham-controlled trials and represents a device-based treatment option for hypertension. We sought to project clinical event reductions after radiofrequency renal denervation using a novel modelling approach.

Methods and results
The Global SYMPLICITY Registry is a global, prospective all-comer registry to evaluate safety and efficacy after renal denervation. For this analysis, change in office systolic blood pressure from baseline was calculated from reported follow-up in the Global SYMPLICITY Registry. Relative risks for death and other cardiovascular events as well as numbers needed to treat for event avoidance were obtained for the respective blood pressure reductions based on previously reported meta-regression analyses for the full cohort and high-risk subgroups including type 2 diabetes, chronic kidney disease, resistant hypertension, and high basal cardiovascular risk. Average baseline office systolic blood pressure and reduction estimates for the full cohort (N = 2651) were 166±25 and −14.8 ± 0.4 mmHg, respectively. Mean reductions in blood pressure ranged from −11.0–−21.8 mmHg for the studied high-risk subgroups. Projected relative risks ranged from 0.57 for stroke in the resistant hypertension cohort to 0.92 for death in the diabetes cohort. Significant absolute reductions in major adverse cardiovascular events over 3 years compared with the projected control (8.6 ± 0.7% observed vs. 11.7 ± 0.9% for projected control; P &lt; 0.01) were primarily due to reduced stroke incidence. The robustness of findings was confirmed in sensitivity and scenario analyses.

Conclusion
Model-based projections suggest radiofrequency renal denervation for patients with uncontrolled hypertension adds considerable clinical benefit across a spectrum of different cohort characteristics.
Differences in epiphytic trunk communities in secondary forests and plantations of southern Ecuador
Authors: Fernández-Prado Noelia , Aragón Gregorio , Prieto María , Benítez Ángel , Martínez Isabel 
Published: August 2022

Abstract
Deforestation is the most important cause of biodiversity loss in tropical ecosystems. Epiphytic species, lichens and bryophytes, are very sensitive to environmental changes, including those produced by conversion of primary forests into secondary vegetation. However, little is known about the differences between different secondary forests and plantations regarding the epiphytic biota. We compared epiphytic communities among different secondary forests and non-native plantations in southern Ecuador. Four forest types were considered: non-native Pinus patula plantations, monospecific secondary forests of Alnus acuminata, monospecific secondary forests of Andesanthus lepidotus and mixed secondary forests. Within each forest type, two stands were surveyed, establishing a total of 80 plots and analyzing four trees per plot. We estimated lichen and bryophyte cover in four inventories per tree and calculated and compared different metrics for taxonomic and functional diversity, as well as community composition. The results revealed forest type as the major predictor for the species and functional traits richness, and for diversity and composition. In total, 422 taxa were identified (312 lichens and 110 bryophytes), with mixed secondary forests having the richest communities (194 species) and non-native plantations having the lowest richness (105 species). Bryophyte richness was highest in A. lepidotus forests. Taxonomic and functional diversity, and species composition differed greatly among forest types and followed a different pattern depending on the organism considered. Lichens were the most sensitive indicators of environmental conditions associated with different tropical forest types.
An analysis of the steepest descent method to efficiently compute the three-dimensional acoustic single-layer operator in the high-frequency regime
Authors: Gasperini D , Beise H- P , Schroeder U , Antoine X , Geuzaine C 
Published: August 2022

Abstract
Using the Cauchy integral theorem, we develop the application of the steepest descent method to efficiently compute the three-dimensional acoustic single-layer integral operator for large wave numbers. Explicit formulas for the splitting points are derived in the one-dimensional case to build suitable complex integration paths. The construction of admissible steepest descent paths is next investigated and some of their properties are stated. Based on these theoretical results, we derive the quadrature scheme of the oscillatory integrals first in dimension one and then extend the methodology to three-dimensional planar triangles. Numerical simulations are finally reported to illustrate the accuracy and efficiency of the proposed approach.
Not So Dangerous? Nationalism and Foreign Policy Preference
Authors: Ko Jiyoung 
Published: August 2022

ABSTRACT
In the field of international relations, it has long been believed that nationalism generates adverse foreign policy preferences. This article revisits this long-standing assumption by investigating how stimulating nationalistic sentiments shapes mass foreign policy preferences in two contexts, namely when celebrating national achievements and greatness with a focus on the national Self and when invoking negative historical memories in relation to a salient Other. Using a survey experiment conducted in China, which capitalized on visual stimuli drawn from real-world sources to stoke respondents’ nationalistic sentiments, this article shows that not all rises of nationalism are the same. Adverse foreign policy preferences, such as a preference for a hawkish approach, an uncompromising attitude, and a dislike for the status quo, emerge when nationalistic sentiments are stoked by invoking negative historical memories but not by celebrating general national achievements and greatness.