bluuebunny/crossref_metadata_2025_split huggingface dataset:
Video feedback parent‐infant intervention for mothers experiencing enduring difficulties in managing emotions and relationships: A randomised controlled feasibility trial
Authors: Barnicot Kirsten , Welsh Morgan , Kalwarowsky Sarah , Stevens Eloise , Iles Jane , Parker Jennie , Miele Maddalena , Lawn Tara , O'Hanlon Laura , Sundaresh Sushma , Ajala Ola , Bassett Paul , Jones Christina , Ramchandani Paul , Crawford Mike 
Published: August 2022

AbstractObjectivesParents experiencing mental health difficulties consistent with “personality disorder”, often related to a history of complex trauma, may face increased challenges in parent–child relationships and child socioemotional development. There are no published randomised controlled trials (RCTs) evaluating perinatal parent–child interventions for this population. We evaluated the feasibility and acceptability of undertaking an RCT of the video feedback intervention for positive parenting adapted for perinatal mental health (VIPP‐PMH).DesignFeasibility study incorporating a pilot RCT.MethodsMothers with enduring difficulties in managing emotions and relationships, consistent with a “personality disorder”, and their 6‐ to 36‐month old infants were randomly allocated to receive six sessions of VIPP‐PMH (n = 20) or usual care alone (n = 14).Results76% of eligible mothers consented to participate. Intervention uptake and completion rates were 95% (≥1 VIPP‐PMH session) and 70% (6 sessions), respectively. Follow‐up rates were 85% at month 5 and 65% at month 8 post‐baseline. Blinded observer‐ratings of maternal sensitivity in parent–child interaction favoured the intervention group at month 5 (RR = 1.94, 95% CI 0.67–5.63) and month 8 (RR = 1.91, 95% CI 0.68–5.33). Small changes over time in self‐rated parenting confidence and stress favoured the intervention group. There were no clear intervention effects on maternal non‐intrusiveness or mental health, or on child behaviour problems, emotional functioning, or self‐regulation.ConclusionsAn RCT of VIPP‐PMH is feasible and acceptable to implement with mothers experiencing difficulties consistent with perinatal “personality disorder”. A fully powered definitive RCT should be undertaken.
Prediction of early prognosis after traumatic brain injury by multifactor model
Authors: Yang Bocheng , Sun Xiaochuan , Shi Quanhong , Dan Wei , Zhan Yan , Zheng Dinghao , Xia Yulong , Xie Yanfeng , Jiang Li 
Published: August 2022

AbstractAimsTo design a model to predict the early prognosis of patients with traumatic brain injury (TBI) based on parameters that can be quickly obtained in emergency conditions from medical history, physical examination, and supplementary examinations.MethodsThe medical records of TBI patients who were hospitalized in two medical institutions between June 2015 and June 2021 were collected and analyzed. Patients were divided into the training set, validation set, and testing set. The possible predictive indicators were screened after analyzing the data of patients in the training set. Then prediction models were found based on the possible predictive indicators in the training set. Data of patients in the validation set and the testing set was provided to validate the predictive values of the models.ResultsAge, Glasgow coma scale score, Apolipoprotein E genotype, damage area, serum C‐reactive protein, and interleukin‐8 (IL‐8) levels, and Marshall computed tomography score were found associated with early prognosis of TBI patients. The accuracy of the early prognosis prediction model (EPPM) was 80%, and the sensitivity and specificity of the EPPM were 78.8% and 80.8% in the training set. The accuracy of the EPPM was 79%, and the sensitivity and specificity of the EPPM were 66.7% and 86.2% in the validation set. The accuracy of the early EPPM was 69.1%, and the sensitivity and specificity of the EPPM were 67.9% and 77.8% in the testing set.ConclusionPrediction models integrating general information, clinical manifestations, and auxiliary examination results may provide a reliable and rapid method to evaluate and predict the early prognosis of TBI patients.
Knockdown of ZBTB11 impedes R‐loop elimination and increases the sensitivity to cisplatin by inhibiting DDX1 transcription in bladder cancer
Authors: Chen Lei , Liu Zefu , Tang Huancheng , Zhou Zhaohui , Chen Jiawei , Ma Zikun , Deng Minhua , Li Xiangdong , Wu Yuanzhong , Zheng Lisi , Zhou Liwen , Zheng Xianchong , Liu Zhuowei 
Published: August 2022

AbstractIntroductionBladder cancer (BC) is one of the most common malignant cancers, with poor prognosis and high incidence. Cisplatin is the standard chemotherapy for muscle invasive bladder cancer; however, chemotherapy resistance remains a major challenge. Moreover, oncogenic signalling and the specific mechanisms underlying cisplatin resistance in BC remain largely unclearMethodsIn this study, RT‐PCR, Western blot, immunofluorescence, and immunohistochemistry were used to measure gene and protein expression. Colony formation assay and flow cytometry were performed to evaluate the proliferation of BC cells. Gene set enrichment analysis was performed to identify the function in which ZBTB11 was involved. Luciferase and chromatin immunoprecipitation experiments were performed to determine the transcriptional regulation mechanism of ZBTB11. The effects of ZBTB11 on the malignant phenotypes of BC cells were examined in vitro and in vivoResultsThe results showed that ZBTB11 was remarkably upregulated in BC tissues, which was associated with poor prognosis in patients with BC. Furthermore, we found that knockdown of ZBTB11 remarkably inhibited the proliferation and tumorigenesis of BC cells by inducing apoptosis. Mechanistically, the knockdown of ZBTB11 transcriptionally inhibited DDX1 to suppress R‐loop clearance, resulting in DNA damage in BC cells. Importantly, the ZBTB11/DDX1 axis is required for the chemotherapy resistance of BC cells to cisplatinConclusionOur findings not only reveal an underlying mechanism by which the ZBTB11/DDX1 axis promotes the tumorigenesis of BC but also provide a potential target for a combination strategy of cisplatin‐based chemotherapy for BC.
Hit from abroad: Party dominance and the fiscal response to external economic shocks
Authors: Ramos Pastrana Julio A. 
Published: August 2022

AbstractDo politicians from dominant parties choose different fiscal policies in response to an external economic shock than politicians from competitive parties? This paper argues that politicians from dominant parties might adopt different fiscal policies than politicians from competitive parties in response to an external economic shock. Politicians from dominant parties might enjoy a political advantage that allows them to underinvest in areas with low political gains compared to politicians from competitive parties and divert the money to policy areas more politically profitable. I examine my theoretical prediction using a panel data set of Mexican governors from 1995 to 2010.
Body size, metabolic rate and diapause in the oriental hornet (Vespa orientalis), in two extreme climatic regions
Authors: Cohen Nitzan , Volov Mika , Bodner Levona , Bouchebti Sofia , Levin Eran 
Published: August 2022

Abstract
Temperature and precipitation are major components of climate that have a pervasive effect on the phenotype and physiology of insects.
The Oriental hornet has a wide geographical distribution and is the only vespid species found in a desert environment.
Recently, it has extended its geographic distribution due to climate change and human activities.
We compared the standard metabolic rate, diapause metabolic rate and body size of workers and gynes in two different climatic regions, 150 km apart along the northern part of the Great Rift Valley in Israel: In the north, high elevation Mediterranean habitat and in the south, low elevation, warm and dry desert.
The brood in the desert region developed in higher ambient temperatures than in the Mediterranean, but only the workers of the desert had a smaller body size as adults.
Worker hornets from the Mediterranean region had a higher standard metabolic rate (SMR) at the environmental temperature of main activity compared to desert hornets.
Queens had a typical discontinuous gas exchange cycles (DGC) pattern, with Mediterranean queens having a 30% lower SMR.
Such lower SMR might reflect an adaptation for prolonged and more profound diapause typical to the cold and long winter conditions in this region.
Time course of right‐hemisphere recruitment during word production following left‐hemisphere damage: A single case of young stroke
Authors: Chupina Irina , Sierpowska Joanna , Zheng Xiaochen Y. , Dewenter Anna , Piastra Maria‐Carla , Piai Vitória 
Published: August 2022

AbstractOur understanding of post‐stroke language function is largely based on older age groups, who show increasing age‐related brain pathology and neural reorganisation. To illustrate language outcomes in the young‐adult brain, we present the case of J., a 23‐year‐old woman with chronic aphasia from a left‐hemisphere stroke affecting the temporal lobe. Diffusion MRI‐based tractography indicated that J.'s language‐relevant white‐matter structures were severely damaged. Employing magnetoencephalography (MEG), we explored J.'s conceptual preparation and word planning abilities using context‐driven and bare picture‐naming tasks. These revealed naming deficits, manifesting as word‐finding difficulties and semantic paraphasias about half of the time. Naming was however facilitated by semantically constraining lead‐in sentences. Altogether, this pattern indicates disrupted lexical‐semantic and phonological retrieval abilities. MEG revealed that J.'s conceptual and naming‐related neural responses were supported by the right hemisphere, compared to the typical left‐lateralised brain response of a matched control. Differential recruitment of right‐hemisphere structures (330–440 ms post‐picture onset) was found concurrently during successful naming (right mid‐to‐posterior temporal lobe) and word‐finding attempts (right inferior frontal gyrus). Disconnection of the temporal lobes via corpus callosum was not critical for recruitment of the right hemisphere in visually guided naming, possibly due to neural activity right lateralising from the outset. Although J.'s right hemisphere responded in a timely manner during word planning, its lexical and phonological retrieval abilities remained modest.
Evaluating the suitability of close‐kin mark‐recapture as a demographic modelling tool for a critically endangered elasmobranch population
Authors: Delaval Aurélien , Bendall Victoria , Hetherington Stuart J. , Skaug Hans J. , Frost Michelle , Jones Catherine S. , Noble Leslie R. 
Published: August 2022

AbstractEstimating the demographic parameters of contemporary populations is essential to the success of elasmobranch conservation programmes, and to understanding their recent evolutionary history. For benthic elasmobranchs such as skates, traditional fisheries‐independent approaches are often unsuitable as the data may be subject to various sources of bias, whilst low recapture rates can render mark‐recapture programmes ineffectual. Close‐kin mark‐recapture (CKMR), a novel demographic modelling approach based on the genetic identification of close relatives within a sample, represents a promising alternative approach as it does not require physical recaptures. We evaluated the suitability of CKMR as a demographic modelling tool for the critically endangered blue skate (Dipturus batis) in the Celtic Sea using samples collected during fisheries‐dependent trammel‐net surveys that ran from 2011 to 2017. We identified three full‐sibling and 16 half‐sibling pairs among 662 skates, which were genotyped across 6291 genome‐wide single nucleotide polymorphisms, 15 of which were cross‐cohort half‐sibling pairs that were included in a CKMR model. Despite limitations owing to a lack of validated life‐history trait parameters for the species, we produced the first estimates of adult breeding abundance, population growth rate, and annual adult survival rate for D. batis in the Celtic Sea. The results were compared to estimates of genetic diversity, effective population size (Ne), and to catch per unit effort estimates from the trammel‐net survey. Although each method was characterized by wide uncertainty bounds, together they suggested a stable population size across the time‐series. Recommendations for the implementation of CKMR as a conservation tool for data‐limited elasmobranchs are discussed. In addition, the spatio‐temporal distribution of the 19 sibling pairs revealed a pattern of site fidelity in D. batis, and supported field observations suggesting an area of critical habitat that could qualify for protection might occur near the Isles of Scilly.
Financial strain, the transference of stigma, and residential instability: A qualitative analysis of the long‐term effects of parental incarceration
Authors: Shaw Marcus 
Published: August 2022

AbstractObjectiveThis study seeks to document the long‐term effects of parental incarceration on life course by interviewing adults who had a parent incarcerated when they were a child.BackgroundAn exponential increase in incarceration in the late 20th century has produced many adverse effects and increased social disadvantage for families and communities. From the life course perspective, parental incarceration is argued to be a detrimental experience in numerous ways.MethodsThis study utilizes (N = 31) in‐depth qualitative interviews with adult respondents in California who experienced parental incarceration at some point in their life. The study uses descriptive phenomenology to examine the effects of parental incarceration on life course.ResultsThe themes discussed in this study are financial and emotional strain, residential instability, and the transference of stigma. Financial strain and residential instability were associated with many negative effects for children of incarcerated parents. Participants recalled such experiences as consistently moving residencies, attending multiple schools, homelessness and inability to attend school, and lack of household resources. The transference of stigma occurred when a parent's record became a representation of a child's moral worth. Interviewees reported feeling or experiencing stigmatization, in social and professional settings, due to their parent's incarceration or criminal record.ConclusionThis study illuminates how the life course experience of parental incarceration can have significant long‐term impacts on children, potentially placing them at risk. Documenting the intergenerational impacts of mass incarceration on children and families is of societal importance.
Clinical pattern and response to treatment of primary stabbing headache: Retrospective case series study from a Portuguese tertiary hospital
Authors: Cabral Gonçalo , Saraiva Marlene , Serôdio Miguel , Serrazina Filipa , Salavisa Manuel , Fernandes Marco , Meira Bruna , Ventura Rita , Pinho André , Magriço Marta , Caetano André , Baptista Miguel Viana 
Published: August 2022

AbstractObjectivesThis retrospective case series study aimed to investigate the demographic and clinical patterns of primary stabbing headache (PSH). In addition, we tried to identify subgroups of treatment responses in a neurology outpatient consultation at a Portuguese tertiary hospital.MethodsClinical records were retrospectively reviewed and patients meeting the International Classification of Headache Disorders, 3rd edition, criteria for PSH were identified from January 2014 to December 2020. We collected data regarding demographic characteristics, clinical features of the headache, primary headache comorbidities, and information about treatment‐related do PSH.ResultsOf 1857 patients, 32 (1.7%; mean [SD] age of onset 56 [3.5] years) had the final diagnosis of PSH. Regarding headache characteristics, 20 patients (62.5%) reported episodes of stabbing in fixed locations and 12 (37.5%) in multiple areas; the duration of each attack was between ≤5 s (seven [21.9%]), 5–60 s (20 [62.5%]), and ≥60 s (five [15.6%]). In all, 18 patients (56.3%) had an episodic course (vs. six of 32 [18.8%] an acute course and eight of 32 [25%] a chronic course). In all, 17 patients started medical treatment (53.1%), with total or partial improvement in 10 (58.8%) of them. It was found that patients with pain in fixed locations had a better response to treatment when compared to patients with multiple locations, in a statistically significant way (eight of 11 vs. two of six, p = 0.023).ConclusionIn our sample, the mean age of onset of PSH was >50 years and there was a wide range of PSH duration. The duration of each attack (>5 s), the pain in fixed locations, non‐daily episodes of the pain in each attack, and the intermittent course of headache were the most prevalent clinical features. Finally, patients with stabbing in localized areas had a better response to treatment.
Spontaneous involution of a large pineal cyst: Case report and narrative review
Authors: Bouttelgier Robin M. , Sie Mariska , Hallaert Giorgio G. 
Published: August 2022

AbstractObjectiveTo illustrate the possibility of spontaneous involution of a pineal cyst, justifying an initial observation strategy in patients without evident mass effect.BackgroundPineal cysts are frequent radiological findings, with a reported overall prevalence from 0.6% to 40%. Historically, surgery has been reserved for patients with symptoms attributable to a mass effect of the cyst. Despite the high prevalence of pineal cysts, the clinical approach to patients with non‐specific symptoms remains controversial.MethodsWe report on the spontaneous involution of a large pineal cyst in a 26‐year‐old female who presented in our outpatient clinic with transient symptoms of headache and nausea. PubMed and Web of Science databases were scrutinized using a predefined search strategy in accordance with the Population, Intervention, Comparison and Outcome (PICO) set‐up using “pineal cyst” and “surgery” as search terms. Only peer‐reviewed publications were considered eligible. Titles and abstracts of 1513 manuscripts were screened for relevance. After excluding 1420 publications evaluating non‐relevant pathology, the eligibility of the remaining 93 full‐text records was further assessed and included if they reported patients with pineal cysts presenting with intractable symptoms without hydrocephalus or Parinaud syndrome, and if they documented on their symptomatology and clinical management.ConclusionRecent case series and reviews report favorable results of surgery in patients with pineal cysts but also a potentially high complication rate. However, the evidence offered by these reports is limited and a placebo effect cannot be ruled out. Therefore, surgery cannot be unequivocally advocated in these patients. Instead, an initial surveillance strategy is advocated. We concur with a previously propounded surveillance strategy of a single follow‐up magnetic resonance imaging at 12 months. This case report demonstrates the importance of an initial observation strategy since pineal cysts may also show a spontaneous involution.
Expectant mothers' not fathers' mind‐mindedness predicts infant, mother, and father conversational turns at 7 months
Authors: Foley Sarah , Hughes Claire , Fink Elian 
Published: August 2022

AbstractParental mind‐mindedness (MM), defined as the propensity to view one's child as an agent with thoughts, feelings, and desires, is associated with positive child outcomes (McMahon & Bernier, 2017) and can be assessed in expectant parents by using five‐minute speech samples (Magaña et al., 1986). Individual differences in MM appear stable across the transition to parenthood (Foley et al., in press), offering an exciting intervention opportunity, as expectant mothers' thoughts and feelings about their unborn infants are associated with the quality of mother‐infant interactions. To assess prenatal MM as a predictor of parent‐infant conversation at 7 months, we followed 93 low‐risk British heterosexual couples across the transition to parenthood. Mothers' and fathers' MM was measured both in the third trimester of pregnancy and at 4 months. Wearable LENA devices were used to gather detailed measures of mother‐, father‐, and infant‐initiated conversations at 7 months. Prenatal MM in both parents was associated with more frequent infant‐initiated conversations at 7 months, while prenatal maternal (not paternal) MM was also associated with more mother‐ and father‐initiated conversations. While longitudinal research with more diverse samples is needed, these findings highlight the importance of parental mentalizing in the prenatal period for early family interactions.
Simple and field amenable loop-mediated isothermal amplification-lateral flow dipstick assay for detection of west Nile virus in human clinical samples
Authors: Tomar Priyanka Singh , Patel Sapan , Dash Paban Kumar , Kumar Jyoti S. 
Published: August 2022

Abstract

Aim
West Nile encephalitis caused by infection with the West Nile virus (WNV) is endemic in many regions of the world and is a global public health threat. The aim of this report was to develop a method using colorimetry-based reverse-transcription loop-mediated isothermal amplification (cRT-LAMP) and RT-LAMP combined with lateral-flow dipstick (LFD) for rapidly detecting WNV in low-infrastructure settings.

Methods and Results
The primers for the cRT-LAMP and RT-LAMP-LFD assays were designed based on env gene of the WNV. Primers concentration, temperature and time were optimized for cRT-LAMP and RT-LAMP-LFD. The diagnostic performance of the cRT-LAMP and RT-LAMP-LFD assays was evaluated using human serum samples from 110 patients who were clinically suspected to be infected with WNV. The RT-LAMP was performed in a heating block at 63°C for 40 min. The LAMP amplicons were visible in the lateral-flow dipstick within 5 min. The detection limit of the developed cRT-LAMP and RT-LAMP-LFD assays was 10 copies and this assay showed a high degree of specificity for WNV. Compared with quantitative real-time RT-PCR assay, the kappa value of cRT-LAMP and RT-LAMP-LFD were 0.970.

Conclusions
These results showed that the newly developed WNV-specific cRT-LAMP and RT-LAMP-LFD assays can be employed as an alternative method for screening of WN-suspected human samples. The results revealed that the assay could potentially identify the virus without interference from human serum samples. Collectively, all results revealed that cRT-LAMP and RT-LAMP-LFD assays offer a suitable field-based diagnosis of WNV.

Significance and Impact of the Study
The cRT-LAMP and LAMP-LFD platform for the detection of WNV is rapid, accurate and simple-to-perform. Our present method has not only a short turnaround time but also avoided cross-contamination problem. Moreover, the use of simple lateral flow dipsticks broadens its application potential for the point-of-care use in resource-limited settings during outbreak situations. To the best of our knowledge, this is the first report for the development of cRT-LAMP and LAMP-LFD assays for rapid, simple, specific and sensitive detection of WNV using human clinical samples and EvaGreen dye.