bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vertical distribution patterns and drivers of soil bacterial communities across the continuous permafrost region of northeastern China
Authors: Ren Baihui , Hu Yuanman , Bu Rencang 
Published: January 2022

Abstract
Background
Soil microorganisms in the thawing permafrost play key roles in the maintenance of ecosystem function and regulation of biogeochemical cycles. However, our knowledge of patterns and drivers of permafrost microbial communities is limited in northeastern China. Therefore, we investigated the community structure of soil bacteria in the active, transition and permafrost layers based on 90 soil samples collected from 10 sites across the continuous permafrost region using high-throughput Illumina sequencing.

Results
Proteobacteria (31.59%), Acidobacteria (18.63%), Bacteroidetes (9.74%), Chloroflexi (7.01%) and Actinobacteria (6.92%) were the predominant phyla of the bacterial community in all soil layers; however, the relative abundances of the dominant bacterial taxa varied with soil depth. The bacterial community alpha-diversity based on the Shannon index and the phylogenetic diversity index both decreased significantly with depth across the transition from active layer to permafrost layer. Nonmetric multidimensional scaling analysis and permutation multivariate analysis of variance revealed that microbial community structures were significantly different among layers. Redundancy analysis and Spearman’s correlation analysis showed that soil properties differed between layers such as soil nutrient content, temperature and moisture mainly drove the differentiation of bacterial communities.

Conclusions
Our results revealed significant differences in bacterial composition and diversity among soil layers. Our findings suggest that the heterogeneous environmental conditions between the three soil horizons had strong influences on microbial niche differentiation and further explained the variability of soil bacterial community structures. This effort to profile the vertical distribution of bacterial communities may enable better evaluations of changes in microbial dynamics in response to permafrost thaw, which would be beneficial to ecological conservation of permafrost ecosystems.
Right atrial myxoma as the first manifestation of granulomatosis with polyangiitis, and a possible association with vascular endothelial growth factor (VEGF) and interleukin 6 (IL-6): a case report and review of the literature
Authors: Corin Joel , Carlsson Amanda , Peters Björn 
Published: January 2022

AbstractBackgroundGranulomatosis with polyangiitis and myxomas are rare conditions previously described to co-exist. Cardiac masses are often presumed to be myxomas rather than lesions of granulomatosis with polyangiitis.Case presentationWe present a review of the symptoms for the two diagnoses along with the first verified case.ConclusionsTwo possible risk factors for developing myxomas (VEGF and IL-6) are explored and discussed.
Assessment of COVID-19 vaccines acceptance in the Lebanese population: a national cross-sectional study
Authors: Hanna Philippe , Issa Aline , Noujeim Ziad , Hleyhel Mira , Saleh Nadine 
Published: January 2022

Abstract
Background
Vaccines have become the best weapon for epidemic prevention and control in the absence of standard approved effective therapies. However, skepticism about the vaccine efficacy and safety is constantly reported. To our knowledge, there has been no study assessing COVID-19 vaccine acceptance in Lebanon. The primary objective of this survey is to assess the COVID-19 vaccines’ acceptance and its related determinants in the Lebanese population.

Methods
A cross-sectional study was conducted in Lebanon from February 16 through February 25, 2021. Data was collected using an online questionnaire via social media platforms using the snowball technique. The questionnaire consisted of 47 questions related to sociodemographic and medical history, COVID-19 experience, knowledge, practice, and beliefs towards COVID-19 vaccines, including vaccines acceptance. Binary logistic regression was performed to identify factors associated with vaccine acceptance.

Results
A total of 1209 questionnaires were completed; around 63.4% have reported their acceptance for receiving the COVID-19 vaccine, while only 57% of participants registered themselves on the national platform. The multivariable analysis showed that a higher knowledge scale, living in an urban residential area, having hypertension, not having a food allergy, reporting a higher fear to experience COVID-19 infection, and receiving or wanting to receive influenza vaccine, were positive predictors of COVID-19 vaccines acceptance.

Conclusions
Our findings support the need to improve knowledge about COVID-19 infection and vaccination through education and awareness programs. Specifically residents of rural areas should be targeted to optimize COVID-19 vaccine acceptance among the Lebanese population.
Nanoarchitectured air-stable supported lipid bilayer incorporating sucrose–bicelle complex system
Authors: Tae Hyunhyuk , Park Soohyun , Ma Gamaliel Junren , Cho Nam-Joon 
Published: January 2022

AbstractCell-membrane-mimicking supported lipid bilayers (SLBs) provide an ultrathin, self-assembled layer that forms on solid supports and can exhibit antifouling, signaling, and transport properties among various possible functions. While recent material innovations have increased the number of practically useful SLB fabrication methods, typical SLB platforms only work in aqueous environments and are prone to fluidity loss and lipid-bilayer collapse upon air exposure, which limits industrial applicability. To address this issue, herein, we developed sucrose–bicelle complex system to fabricate air-stable SLBs that were laterally mobile upon rehydration. SLBs were fabricated from bicelles in the presence of up to 40 wt% sucrose, which was verified by quartz crystal microbalance-dissipation (QCM-D) and fluorescence recovery after photobleaching (FRAP) experiments. The sucrose fraction in the system was an important factor; while 40 wt% sucrose induced lipid aggregation and defects on SLBs after the dehydration–rehydration process, 20 wt% sucrose yielded SLBs that exhibited fully recovered lateral mobility after these processes. Taken together, these findings demonstrate that sucrose–bicelle complex system can facilitate one-step fabrication of air-stable SLBs that can be useful for a wide range of biointerfacial science applications.
Three cases of difficulty in achieving definitive loss of consciousness with remimazolam
Authors: Miyanishi Mao , Yaguramaki Toru , Maehara Yasuhiro , Nagata Osamu 
Published: January 2022

Abstract
Background
Remimazolam is a novel, ultra-short-acting benzodiazepine used for general anesthesia. Because remimazolam is an emerging drug, the tolerance to remimazolam in benzodiazepine-taking patients has been unclear. Also, the efficacy of remimazolam in different races is not fully elucidated so far.

Case presentation
Here we experienced three cases in which high dose of remimazolam was needed for attempting to achieve appropriate anesthetic depth. Two of the three cases were of preoperatively benzodiazepine-taking patients. The other was a case of a Chinese patient. In all three cases, conversion to general anesthesia with propofol was necessitated.

Conclusions
When signs of inadequate sedative effect of remimazolam are observed in patients of benzodiazepine users or of different races, conversion to another sedative agent such as propofol should be considered.
Performance of binary prediction models in high-correlation low-dimensional settings: a comparison of methods
Authors: Leeuwenberg Artuur M. , van Smeden Maarten , Langendijk Johannes A. , van der Schaaf Arjen , Mauer Murielle E. , Moons Karel G. M. , Reitsma Johannes B. , Schuit Ewoud 
Published: January 2022

AbstractBackgroundClinical prediction models are developed widely across medical disciplines. When predictors in such models are highly collinear, unexpected or spurious predictor-outcome associations may occur, thereby potentially reducing face-validity of the prediction model. Collinearity can be dealt with by exclusion of collinear predictors, but when there is no a priori motivation (besides collinearity) to include or exclude specific predictors, such an approach is arbitrary and possibly inappropriate.MethodsWe compare different methods to address collinearity, including shrinkage, dimensionality reduction, and constrained optimization. The effectiveness of these methods is illustrated via simulations.ResultsIn the conducted simulations, no effect of collinearity was observed on predictive outcomes (AUC,R2, Intercept, Slope) across methods. However, a negative effect of collinearity on the stability of predictor selection was found, affecting all compared methods, but in particular methods that perform strong predictor selection (e.g., Lasso). Methods for which the included set of predictors remained most stable under increased collinearity were Ridge, PCLR, LAELR, and Dropout.ConclusionsBased on the results, we would recommend refraining from data-driven predictor selection approaches in the presence of high collinearity, because of the increased instability of predictor selection, even in relatively high events-per-variable settings. The selection of certain predictors over others may disproportionally give the impression that included predictors have a stronger association with the outcome than excluded predictors.
Analyzing the relationship between water pollution and economic activity for a more effective pollution control policy in Bali Province, Indonesia
Authors: Chapagain Saroj Kumar , Mohan Geetha , Rimba Andi Besse , Payus Carolyn , Sudarma I. Made , Fukushi Kensuke 
Published: January 2022

AbstractAn adequate water supply is essential for the continued and sustainable growth of the Balinese economy. In addition to mounting water demand, Bali’s water supply has been constrained by high levels of water pollution. Despite being paid great attention, Bali’s earlier efforts to control water pollution yet to prove effective, mainly owing to their reliance on traditional methods and regulations that focus on water pollution being linked to discrete sets of economic activity (e.g., processing industries, livestock farming, and hotels). However, an economy of a region/country comprises a set of sectoral activities, which are interconnected through supply chains; thus, water pollution could be well explained by examining the entire sectoral economic activities and their environmental performance. Therefore, determining the structural relationships between water pollution and economic activity serves as an important basis for more effective forms of pollution control for the Balinese economy. In this study, accordingly, we employed an environmentally extended input–output model to establish the links between water pollution and the production processes of the entire economy. Using biochemical oxygen demand (BOD) as a proxy for water quality in our analysis, we estimated that 246.9 kt of BOD were produced from Bali’s economic activity in 2007. Further, we identified the chief BOD-emitting sectors and found that intermediate demand and household demand were the major causes of BOD discharge in the economy. We also accounted for the indirect role of each sector in total BOD emissions. Moreover, we categorized the sectors into four groups based on their direct and indirect BOD emission characteristics and offered appropriate policy measures for each group. Managing demand (i.e., lowering household consumption and exports) and shifting input suppliers (i.e., from polluters to non-polluters) are effective measures to control pollution for Categories I and II, respectively; clean production and abatement is advised for Category III; and a hybrid approach (i.e., demand management and abatement technology) is recommended for Category IV.
Predictors of admission to intensive care unit among systemic lupus erythematosus patients: prospective study
Authors: Abdelwhab Shimaa Mostafa , Kotb Lobna Ismaeil , Sameer Ghada , Dawa Ghada 
Published: January 2022

Abstract
Background
Through the disease course, different prognostic factors have been addressed in patients with SLE admitted to intensive care unit. For instance, higher disease activity on admission, recent immunosuppressive therapy, infections, renal disease, and central nervous system involvement, all had negative effects on the outcome of the disease. It is still a clinical challenge for the physicians to manage this disease which has many aspects regarding its pathogenesis, clinical presentation, and its outcome remains to be explained.
The aim of our study was determining the course, outcome, and determinants of admission to intensive care unit in patients with systemic lupus erythematosus.

Results
Patients with systemic lupus erythematosus admitted to the intensive care unit in the study sample was 21.4%, and the death rate among them is 18.2%. In our study, the main causes of intensive care admission were cardiovascular causes followed by renal failure then infections. Holding the other covariates constant, a higher value of CRP, SLEDAI, and damage index value is associated with intensive care admission among lupus patients.

Conclusion
Our study showed that systemic lupus erythematosus patients with a higher value of CRP, SLEDAI, and damage index value were liable for intensive care unit admission. Good control of disease activity of SLE which in turn reduces damage of different body systems is mandatory. Periodic screening for functions of renal and cardiac systems is of great value. Proper screening and prophylaxis is recommended against variable causes of infections. Rheumatologists should be careful in controlling SLE active disease and to balance the doses of immunosuppressive especially in the presence of infection. They should focus the research on finding more accurate infection predictive index parameters to early predict the onset of infection.
shinyOPTIK, a User-Friendly R Shiny Application for Visualizing Cancer Risk Factors and Mortality Across the University of Kansas Cancer Center Catchment Area
Authors: Xia Qing , Mudaranthakam Dinesh Pal , Chollet-Hinton Lynn , Chen Ronald , Krebill Hope , Kuo Hanluen , Koestler Devin C. 
Published: January 2022

PURPOSE The University of Kansas Cancer Center (KU Cancer Center) recently developed a data warehouse to Organize and Prioritize Trends to Inform KU Cancer Center (OPTIK). The OPTIK database aggregates and standardizes data collected across the bistate catchment area served by the KU Cancer Center. To improve the usability of the OPTIK database, we developed shinyOPTIK, a user-friendly, interactive web application for visualizing cancer risk factor and mortality rate data across the KU Cancer Center Catchment area. METHODS Data in the OPTIK database were first consolidated at the county level across the KU Cancer Center catchment area. Next, the shinyOPTIK development team met with the KU Cancer Center leadership to discuss the needs and priorities of the shinyOPTIK web application. shinyOPTIK was developed under the R Shiny framework and consists of a user interface (ui.R) and a web server (server.R). At present, s hinyOPTIK can be used to generate county-level geographical heatmaps; bar plots of demographic, screening, and risk factors; and line plots to visualize temporal trends at different Rural-Urban Continuum Codes (RUCCs), rural-urban status, metropolitan, or county levels across the KU Cancer Center catchment area. RESULTS Two examples, adult obesity prevalence and lung cancer mortality, are presented to illustrate how researchers can use shinyOPTIK. Each example is accompanied by post hoc visualizations to help explain key observations in terms of rural-urban disparities. CONCLUSION Although shinyOPTIK was developed to improve understanding of spatial and temporal trends across the population served by the KU Cancer Center, our hope is that the description of the steps involved in the creation of this tool along with open-source code for our application provided herein will serve as a guide for other research centers in the development of similar tools.
The Multiple Simultaneous Temporalities of Global Modernity: Pamuk, Tanpınar, Proust
Authors: Mathew Shaj 
Published: January 2022

Abstract
This essay proposes the theory of multiple simultaneous temporalities as a constitutive feature of global modernism. It spotlights varieties of heterogeneous time—outside but alongside the homogeneous empty time of clocks and calendars—in modernist literature. These overlapping temporalities replace the linear succession of past, present, and future with a principle of nonteleology. The multiple simultaneous temporalities of these works analogize the multiple simultaneous temporalities of global modernity. Thus the temporalization of difference that separates developed nations from developing ones is refuted by the pluralization of temporality. The simultaneity of these temporalities denies, a priori, the ideology of progress. The essay makes this point through a series of interlaced epiphanies about time, across time, staging an East-West comparison that reflects the creole nature of global modernity. It does so via readings of interconnected novels by Orhan Pamuk, Ahmet Hamdi Tanpınar, and Marcel Proust.
Imaging manifestations of juvenile hyaline fibromatosis: a case report and literature review
Authors: Yu Jinfen , Wang Linsheng , Tian Jing , Yu Xuewen , Sun Lixin 
Published: January 2022

Objective:Juvenile hyaline fibromatosis (JHF) is an autosomal recessive condition caused by a mutation in capillary morphogenesis gene 2 (CMG2) on chromosome 4q21. JHF is an extremely rare genetic disorder, and fewer than a hundred cases have been reported worldwide. In this case report, the clinical features, histopathological features and imaging manifestations of a case of JHF are presented. We present imaging manifestations of one case of JHF to deepen the radiologist’s understanding of this condition. The histopathological feature of JHF is hyaline degeneration involving skeletal muscle. Therefore, the lesion has a slightly high density on CT imaging, iso- or hypointense signal on T1WI and hypointense signal on T2WI. The boundary between the lesion and skeletal muscle is unclear.Methods:An 8-year-old male (Case 1) was examined in our department with a complaint of multiple masses on the head, neck and back in 2021. The boy was the only child of his parents and was delivered at 40 weeks gestation by caesarean section. His parents were non-consanguineous.Results :JHF displays multiple slowly or rapidly growing subcutaneous nodules. The imaging manifestations can reflect histopathological components, including nodular connective tissue and amorphous, partially calcified hyaline material.
Development of a computer-assisted instructional package for life skills to prevent risky sexual behaviors in early adolescents, Bangkok, Thailand
Authors: Neranon Wanida , Thongsong Ladaporn 
Published: January 2022

Background: The purpose of the present study was to examine the effects of a newly developed computer-assisted instructional package for life skills (CAIFLS) specifically designed to raise awareness of risky sexual behaviors among Thai early adolescents in Bangkok. Methods: The research process included two phases: (1) the development and (2) the use and evaluation of the newly developed CAIFLS package. First, 5 teachers and 5 Grade 7 students of a Bangkok school were interviewed to collect information needed for the development of CAIFLS. The second phase was to implement learning activities through CAIFLS with a total of 87 Bangkok school students, consisting of 44 students for the experimental group who received CAIFLS for 4 sessions, and 43 students for the control group who received routine class lecture. CAIFLS instructions, lesson plans and worksheets were designed as the experiment methods. Then questionnaires of life skills assessments and student satisfaction were used to investigate the effects and the student satisfaction of CAIFLS. Results: The findings revealed that the efficiency values of the CAIFLS package were 80.2/82.5, higher than the set criteria of 80/80. Mean scores on life skills for the experimental group significant increased (p < .05), which was higher than the control group. The students also showed their satisfaction of CAIFLS at a high level (M = 4.20, S.D. = 0.29) Conclusions: CAIFLS can be used as an effective learning tool to enhance life skills to prevent risky sexual behaviors among Thai early adolescents.
What are the active ingredients of ‘arts in health’ activities? Development of the INgredients iN ArTs in hEalth (INNATE) Framework
Authors: Warran Katey , Burton Alexandra , Fancourt Daisy 
Published: January 2022

Background: There is a scarcity of research concerning what it is about arts engagement that may activate causal mechanisms leading to effects on health and wellbeing outcomes: their active ingredients. Further, the limited studies that do exist have tended to be relevant to specific contexts and types of art forms. The aim of this study was to carry out a comprehensive mapping of potential active ingredients, construct a shared language, and propose a framework and toolkit to support the design, implementation, and evaluation of arts in health activities. Methods: Drawing upon Rapid Appraisal techniques and collaborating with 64 participants, we engaged in a three-phase process: 1) a scoping review to inform the development of an initial framework; 2) consultation on the initial framework; and 3) analysis and construction of the INNATE framework. Results: The study identified 139 potential active ingredients within the overarching categories of project, people, and contexts. Project components relate directly to the content of the arts activity itself, intrinsic to what the activity is. The people category denotes how people interact through engagement with the activity and who is involved in this interaction, including activity facilitation. Contexts relates to the activity setting comprising the aggregate of place(s), things, and surroundings. Aligning with complexity science, Ingredients may overlap, interconnect, or feed into one another to prompt mechanisms, and may not be experienced as distinct by participants. Conclusions: Our mapping exercise is the most extensive to date. In relation to arts in health activities, the INNATE framework can support with: design and implementation, such as co-producing an intervention to meet the needs of a particular population; evaluation, such as facilitating the comparison of different interventions and their efficacy; and replication, scalability, and sustainability through enabling detailed reporting and specific articulation of what an arts in health activity entails.