bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Locally Delivered Apocynin on Fat Graft Survival in an Experimental Rat Animal Model
Authors: Çakan Doğan , Eroğlu Sinem , Keskin Ekrem Ramazan 
Published: January 2022

AbstractWe aimed to investigate the efficacy of locally delivered apocynin on fat graft survival in an experimental autologous fat grafting (AFG) model created in rats. Twenty-one Wistar albino male rats were included in this study. The 0.647 g mean weight grafts were harvested from the inguinal region and transferred to the nape of every rat. The subjects were randomly separated into three groups. Saline, dimethyl sulfoxide (DMSO), and apocynin, a dose of 20 mg/kg, solutions were applied once a day for 2 weeks. After 3 months, the rats were sacrificed. The evaluation of physical measurements (weight and volume) and survival rates of the grafts for volume and weight, the viable cell count (VC) with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and histopathological parameters were done. All biophysical parameters were found to be significantly higher in the apocynin group compared with other groups (p < 0.05). In the MTT test, the saline group was normalized to 100%. According to this, DMSO and apocynin groups' means were 106 and 163%, respectively. The VC was significantly higher in the apocynin group than the other groups (p < 0.05). The VC was significantly higher in the DMSO group than in the saline group (p < 0.05). No significant difference was found in other comparisons performed according to biophysical and histopathological parameters (p > 0.05). The locally delivered apocynin decreases fat graft volume loss in an experimental AFG model. Consequently, apocynin can be used as an effective substance to increase graft survival. The level of evidence was not available.
Thrombotic Risk Determined by Protein C Receptor (PROCR) Variants among Middle-Aged and Older Adults: A Population-Based Cohort Study
Authors: Manderstedt Eric , Halldén Christer , Lind-Halldén Christina , Elf Johan , Svensson Peter J. , Engström Gunnar , Melander Olle , Baras Aris , Lotta Luca A , Zöller Bengt ,   for the Regeneron Genetics Center
Published: January 2022

Abstract
Background The protein C (PC) anticoagulant system has a key role in maintaining hemostatic balance. One missense (Ser219Gly) variant in the PC receptor (PROCR) was associated with venous thromboembolism (VTE) in genome-wide association studies.
Objectives This study aimed to determine the thrombotic risk of rare and common PROCR variants in a large population-based cohort of middle-aged and older adults.
Methods The exonic sequence of PROCR was analyzed for the Ser219Gly variant and other qualifying variants in 28,794 subjects (born 1923–1950, 60% women) without previous VTE, who participated in the Malmö Diet and Cancer study (1991–1996). Incidence of VTE was followed up until 2018. Qualifying variants were defined as loss-of-function or nonbenign (PolyPhen-2) missense variants with minor allele frequencies (MAFs) <0.1%.
Results Re-sequencing identified 36 PROCR variants in the study population (26,210 non-VTE exomes and 2,584 VTE exomes), 11 synonymous, 22 missense, and three loss-of-function variants. Kaplan–Meier analysis of the known Ser219Gly variant (rs867186) showed that homozygosity for this variant increased the risk of disease, whereas heterozygosity showed no effect. Cox multivariate regression analysis revealed an adjusted hazard ratio (HR) of 1.5 (95% confidence interval [CI]: 1.1–2.0). Fifteen rare variants were classified as qualifying and were included in collapsing analysis (burden test and SKAT-O). They did not contribute to risk. However, a Arg113Cys missense variant (rs146420040; MAF = 0.004) showed an increased VTE risk (HR = 1.3; 95% CI: 1.0–1.9).
Conclusion Homozygosity for the Ser219Gly variant and a previously identified functional PROCR variant (Arg113Cys) was associated with VTE. Other variants did not contribute to VTE.
All that Clots Is Not Blood: Bone Cement Implantation Syndrome Presenting as an Intracardiac Mass and Pulmonary Embolism
Authors: Cheong May Anne , Chew Kenneth Michael 
Published: January 2022

AbstractBone cement implantation syndrome (BCIS) is a rare and potentially fatal perioperative complication of cemented orthopaedic surgery. A computed tomography pulmonary angiogram and echocardiogram images were acquired from an 88-year-old patient who had a perioperative collapse while undergoing a revision operation for a peri-implant fracture of the right femoral neck. Findings were suggestive of an intracardiac clot connected to a saddle pulmonary artery embolus. The patient also developed disseminated intravascular coagulation. Overall findings were suggestive of BCIS.
Temporal Trends in the Physical Fitness of Hong Kong Adolescents
Between 1998 and 2015
Authors: Poon Eric Tsz-Chun , Tomkinson Grant R. , Huang Wendy Yajun , Wong Stephen Heung-Sang 
Published: January 2022

AbstractLow physical fitness in adolescence is linked with increased cardiometabolic risk
and early all-cause mortality. This study aimed to estimate temporal trends in
the physical fitness of Hong Kong adolescents aged 12–17 years between
1998 and 2015. Physical fitness (9-min run/walk, sit-ups, push-ups, and
sit-and-reach) and body size data in a total of 28,059 adolescents tested across
five population-representative surveys of Hong Kong secondary school pupils,
were reported. Temporal trends in means were estimated at the gender-age level
by best-fitting sample-weighted linear regression, with national trends
estimated by a post-stratified population-weighting procedure. Overall, there
were small declines in 9-min run/walk (effect size
(ES)=−0.29 (95%CI: −0.32, −0.26)) and
sit-ups performance (ES=−0.24 (95%CI: −0.27,
−0.21)), with negligible changes in push-ups and sit-and-reach
performance. There were small concurrent increases in both mean height and body
mass, with a negligible increase in sum of skinfolds. Trends in mean physical
fitness and body size/were not always uniform across the population
distribution. The small declines in mean 9-min run/walk and sit-ups
performance for Hong Kong adolescents are suggestive of corresponding declines
in cardiorespiratory fitness and abdominal/core endurance, respectively.
Increased national health promotion strategies are required to improve existing
trends.
Diffuse Leptomeningeal Glioneuronal Tumor in an Adult: A Diagnostic Challenge
Authors: Bhaskar Mukesh Kumar , Meel Mukta , Mathur Kusum , Jindal Arpita , Khandelwal Mohit 
Published: January 2022

AbstractHere we report a rare case of diffuse leptomeningeal glioneuronal tumor (DLGNT) in a 35-year-old man, who was misdiagnosed twice as having tuberculosis meningitis and later racemose neurocysticercosis. His delayed diagnosis of DLGNT might be due to prevalence of tuberculosis in our country, similarity in magnetic resonance imaging finding of prominent leptomeningeal enhancement in different cisterns of brain, and extreme rarity of DLGNT in the adults. So, it should be differentiated clinically and radiographically from granulomatous or infectious conditions. Hence, a timely histologic diagnosis through a leptomeningeal biopsy of the brain and spinal cord in case of unusual leptomeningeal enhancement with uncertain laboratory findings is essential because cytological examination of the cerebrospinal fluid in DLGNT is known to be negative.
Quality of Life, Social Support, Coping Strategies, and Psychiatric Morbidity in Patients with Rheumatoid Arthritis
Authors: Nebhinani Naresh , Mattoo Surendra Kumar , Wanchu Ajay 
Published: January 2022

Abstract

Background and Objectives Patients with rheumatoid arthritis (RA) have greater psychological morbidity, despite that research in this area is scarce from developing countries. This study was aimed to assess the association of quality of life, social support, coping strategies, and psychological morbidity in patients with RA.

Materials and Methods In this cross-sectional study, 40 patients with RA, who were not receiving steroids or disease modifying antirheumatic drugs, were recruited through purposive sampling. Social support questionnaire, coping strategy check list, and World Health Organization quality of life-BREF (WHOQOL-BREF) were administered to assess social support, coping, and quality of life, respectively.

Results More than half of the patients had psychiatric disorders (60%), with depression being the commonest disorder (52.5%). Internalization coping and disease severity indicators like tender joints counts, swollen joints counts, pain, and disease activity were found as significant predictors for psychiatric disorders, while externalization coping, quality of life (all domains), and physical functions were found to protect against psychiatric morbidity.

Conclusions Coping, quality of life, disease severity, and physical functions predicted the psychiatric disorders in RA. Multipronged interventions to enhance quality of life with promoting adaptive coping and timely treatment may further improve their mental health and overall disease course.
Design and simulations of a prototype nanocircuit to transmit microwave and terahertz harmonics generated with a mode-locked laser
Authors: Hagmann Mark J. , Martin Isaac 
Published: January 2022

Earlier, we focused a mode-locked laser on the junction of a scanning tunneling microscope. This superimposed currents at the first 200 harmonics of the laser pulse-repetition frequency on the DC tunneling current. The power at each harmonic varied inversely as the square of its frequency because the spectrum analyzer and its cable formed a low-pass filter. However, analysis suggests that in the tunneling junction, the harmonics do not decay below 45 THz. We propose to make nanocircuits to mitigate the roll-off of the output power up to 45 THz. Each nanocircuit will have an optical antenna to receive the laser radiation, field emission diodes to generate the harmonics, and filters to select the harmonics transmitted by a second antenna. Harmonics that are transmitted in a bandwidth that is proportional to the center frequency for that band have an output power proportional to the square of the center frequency because of the fixed spacing of the adjacent harmonics. Thus, these nanocircuits may provide the greatest output power at frequencies approaching 45 THz. The harmonics may be modulated by the presence of specific chemicals or other local phenomena. Thus, scanning the laser over a group of nanocircuits could be used to measure these phenomena with unprecedented resolution.
Symmetry-dependent electronic structure transition in graphether nanoribbons
Authors: Jiang Yue , Guo Yandong , Zeng Hongli , Lin Liyan , Yan Xiaohong 
Published: January 2022

Graphether, a two-dimensional oxocarbon monolayer, has attracted wide attention due to its excellent mechanical, thermal, and electrical performance. Armchair-edged graphether nanoribbons (AGENRs) are investigated through first-principles calculations. It is found that symmetry plays a key role in band structures, which could trigger an indirect–direct transition of the bandgap, following the odd–even parity of the nanoribbon. Furthermore, the asymmetrical electronic structure caused by edge hydrogen passivation would induce semiconducting–metallic transition. Our findings imply that the electronic structure properties of AGENRs could be modulated by symmetry, which may throw light on the band engineering of related devices and the design of heterostructures.
B cell–derived IL-27 promotes control of persistent LCMV infection
Authors: Pratumchai Isaraphorn , Zak Jaroslav , Huang Zhe , Min Booki , Oldstone Michael B. A. , Teijaro John R. 
Published: January 2022

Significance
Persistent viral infection remains a major source of global morbidity and mortality. Studies using a persistent clone of lymphocytic choriomeningitis virus (LCMV) revealed that in addition to optimal functions and interactions of T and B cells, production of cytokines is essential in promoting long-term control of infection. Here we report that B cells are an indispensable source of IL-27 during persistent LCMV infection. B cell–derived IL-27 promotes viral control via supporting accumulations of virus-specific CD8 and CD4 T cells. During later stages of infection, B cell–derived IL-27 promotes production of IFN-γ and IL-21 by virus-specific CD4 T and Tfh cells, respectively. Our study unveils the critical role of a B cell–secreted cytokine in controlling a persistent infection.
Innovative binomial adjectives in Japanese food descriptions and beyond
Authors: Akita Kimi , Murasugi Keiko 
Published: January 2022

Abstract
Over the past two decades, the casual register of Japanese has developed a new class of binomial adjectives, such as fuwa-toro ‘fluffy and creamy’ and gū-kawa ‘overwhelmingly cute’. These terms are particularly common in creative, nuanced descriptions of food, fashion, and personality. This paper identifies four general constraints on the element ordering of these binomial adjectives that apply to different parts of the morphological network. Similar to mimetic (ideophonic) words, these adjectives are immediate to specific situations or sensory experiences and help us to express subjective, multimodal impressions that are otherwise inexpressible.
The threshold of productivity and the ‘irregularization’ of verbs in Early Modern English
Authors: Ringe Don , Yang Charles 
Published: January 2022

Abstract
This paper tests whether Yang’s Tolerance Principle (TP) is useful in explaining one type of morphological change in the history of English. We suggest that some, but not all, innovative non-default past tenses that appear in the written record between 1500 and 1700 can be explained by the TP and thus could be the results of innovation in native language acquisition (NLA).
Prepositions in Early Modern English argument structure and beyond
Authors: Zehentner Eva , Hundt Marianne 
Published: January 2022

Abstract
This paper is the first to use a bottom-up, corpus-based, exploratory approach to the full range of prepositions in Early Modern English argument structure. Contrary to what previous research leads us to expect, the overall token frequency of prepositions during this period decreases, and they are not always successful against the older NP-variants. Similarly, our case study challenges earlier suggestions that PP-complements are particularly frequent in second-language varieties of English. With respect to the functions taken on by PPs in the clause, however, we provide preliminary evidence that more complement-like uses increase at the expense of more adjunct-like arguments, i.e., that PPs become more important as core elements of the clause.
Shifting responsibility in passing information
Authors: Mazzon Gabriella 
Published: January 2022

Abstract
Within the subfield of historical pragmatics, this paper focuses on the linguistic means used for transmitting knowledge and signalling stance in a sample of Early Modern diplomatic correspondence, a text-type that, while partly codified and formulaic, shows individual variation according to topic, correspondents, and other contextual factors. Sir Thomas Bodley’s diplomatic missions in several countries produced a substantial corpus of correspondence between him and the Court. The paper examines Bodley’s strategies for the reporting and assessment of information, while conveying different levels of involvement vs. distancing. The results show that Bodley is especially cautious about the reliability of sources of the information he gathers, as is shown by the vast array of linguistic means he employs to convey his stance towards the information and its sources.
An account of the use of fronting and clefting in Cornish English
Authors: Corral Esteban Avelino 
Published: January 2022

Abstract
Unlike Standard English, Celtic English varieties
generally use word order shifts or special syntactic devices to give
emphasis to a specific clausal constituent. This study analyses the
frequency of use of focusing devices in a number of Cornish English stories
and compares the results with those obtained in other studies for other
Celtic English varieties. Likewise, this chapter attempts to provide an
explanation for why Cornish English shows a preference for fronting over
clefting by referring to the structure of focal constructions in Cornish.
Finally, I offer an account of the discourse-pragmatic functions of fronting
and clefting in Cornish English and compares them with those found in
Standard English to provide evidence in support of its Celtic
substratum.
Old Northumbrian in the Scottish Borders
Authors: Hough Carole 
Published: January 2022

Abstract

Recovering the Earliest English Language in
Scotland: Evidence from place-names (REELS) is a research
project funded for three years by The Leverhulme Trust at the University of
Glasgow: http://berwickshire-placenames.glasgow.ac.uk/. The project team
is using a place-name survey of the historical county of Berwickshire in the
Scottish Borders, the heartland of Anglo-Saxon settlement in Scotland from
the seventh to eleventh centuries, to investigate the Northumbrian dialect
of Old English and its development into Older Scots. The place-name data are
being analysed for evidence of the lexis, semantics, morphology and
phonology of Old Northumbrian, a language variety poorly attested in other
(written and epigraphic) sources. This chapter presents some discoveries
from the ongoing project, alongside a discussion of the strengths and
limitations of place-name evidence in this context.
Measuring the free energy of hard-sphere colloidal glasses
Authors: Dang Minh Triet , Gartner Luka , Schall Peter , Lerner Edan 
Published: January 2022

Abstract
Free energy is a key thermodynamic observable that controls the elusive physics of the glass transition. However, measuring the free energy of colloidal glasses from microscopy images is challenging due to the difficulty of measuring the individual particle size in the slightly polydisperse glassy systems. In this paper, we carry out experiments and numerical simulations of colloidal glasses with the aim to find a practical approach to measure the free energy from colloidal particles at mild polydispersity. We propose a novel method which requires only the particle coordinates from a few confocal microscopy snapshots to estimate the average particle diameter and use it as an input for our experimental free energy measurements. We verify our free energy calculations from Cell Theory with the free energy obtained by Thermodynamic Integration. The excellent agreement between the free energies measured using the two methods close to the glass transition packing fraction highlights the dominant role played by vibrational entropy in determining a colloidal glass’s free energy. Finally, the noticeable free energy difference calculated from uniform and conjectured particle sizes emphasizes the sensitivity on particle free volumes when measuring free energy in the slightly polydisperse colloidal glass.
Observation of Griffiths phase, critical exponent analysis and high magnetocaloric effect near room temperature at low magnetic field in V-doped La0.7Sr0.3MnO3
Authors: G Jagadish Kumar , Jose Ashika , Jinu E P , Saravanan T T , Senthil Kumar E , Navaneethan M , Sreemoolanadhan H , Kamala Bharathi K 
Published: January 2022

Abstract
We report on observation of the Griffiths phase (GP), high magnetocaloric properties at low magnetic fields and temperature-dependent critical exponents of La0.7Sr0.3V
x
Mn1−x
O3 (x = 0, 0.05 and 0.1) perovskite bulk materials. The Curie temperature (T
C) of pure La0.7Sr0.3MnO3 (LMSO) is seen to be 368.7 K and decreases toward room temperature (RT) (342.2 K) by 10 mol% V doping at the Mn site. V doping leads to an enhancement in magnetic entropy change (−ΔS
M) from 1 J kg−1 K−1to 1.41 J kg−1 K−1. V doping at a Mn site leads to the formation of GP, a magnetic disorder due to the coexistence of a paramagnetic (PM) matrix and short-range ferromagnetic (FM) clusters. X-ray photoelectron spectroscopy analysis confirms the presence of mixed-valence V4+/V5+along with Mn3+/Mn4+ ions contributing to various double exchange interactions. The natures of phase transitions and magnetic interactions are analyzed by evaluating critical exponents δ, β, and γ. All the samples show second-order FM to PM phase transition, confirmed from the modified Arrott plots and critical exponent analysis carried out using the Kouvel–Fisher method. The enhancement in magnetic entropy change along with the decrease in Curie temperature toward RT by V doping in the LMSO oxides indicates the possible application of these materials in magnetic refrigeration at low magnetic fields.
Loss of classicality in alternating spin-

12

/spin-1 chain, in the presence of next-neighbor couplings and Dzyaloshinskii–Moriya interactions
Authors: Lahiri Abhiroop , Pati Swapan K 
Published: January 2022

Abstract
We have considered and alternating spin-

1

2

/spin-1 chain with nearest-neighbor (NN) (J
1), next-nearest neighbor (NNN) (J
2) antiferromagnetic (AFM) Heisenberg interactions along with z-component of the Dzyaloshinskii–Moriya (DM) (Dz
) interaction. The Hamiltonian has been studied using (a) linear spin-wave theory and (b) density matrix renormalization group. The system had been reported earlier as a classical ferrimagnet only when NN exchange interactions are present. Both the AFM NNN interactions and DM interactions introduce strong quantum fluctuations and due to which all the signatures of ferrimagnetism vanishes. We find that the nonzero J
2 introduces strong quantum fluctuations in each of the spin sites due to which the z-components of both spin-1 and spin-1/2 sites average out to be zero. The ground state becomes a singlet. The presence of J
1 along with Dz
introduces a short range order but develops long range order along the XY plane. J
1 along with J
2 induces competing phases with structure factor showing sharp and wide peaks, at two different angles reflecting the spin spiral structure locally as well as in the underlying lattice. Interestingly, we find that the D

z
term removes the local spin spiral structure in z-direction, while developing a spiral order in the XY plane.
The acute radiation syndrome—need for updated medical guidelines
Authors: Stenke Leif , Hedman Christel , Lagergren Lindberg Marita , Lindberg Karin , Valentin Jack 
Published: January 2022

Abstract
The major immediate and severe medical consequences in man following exposure to high doses of ionising radiation can be summarised within the concept of the acute radiation syndrome (ARS). In a dose-dependent fashion, a multitude of organ systems can be affected by such irradiation, presenting considerable medical challenges to treating physicians. Accidents or malevolent events leading to ARS can provoke devastating effects, but they occur at a low frequency and in a highly varying manner and magnitude. Thus, it is difficult to make precise medical predictions and planning, or to draw conclusive evidence from occurred events. Therefore, knowledge from on-going continuous developments within related medical areas needs to be acknowledged and incorporated into the ARS setting, enabling the creation of evidence-based guidelines. In 2011 the World Health Organization published a first global consensus on the medical management of ARS among patients subjected to nontherapeutic radiation. During the recent decade the understanding of and capability to counteract organ damage related to radiation and other agents have improved considerably. Furthermore, legal and logistic hurdles in the process of formally approving appropriate medical countermeasures have been reduced. We believe the time is now ripe for developing an update of internationally consented medical guidelines on ARS.