bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intervention in professional dance students to increase mental health- and nutrition literacy: A controlled trial with follow up
Authors: Mathisen Therese Fostervold , Sundgot-Borgen Christine , Anstensrud Beate , Sundgot-Borgen Jorunn 
Published: September 2022

IntroductionThere is a need to change the culture within the art of dance, as it has been associated with injuries and mental health consequences. This study evaluates an intervention designed to increase mental health literacy, enhance nutritional knowledge, reduce symptoms and effects of low energy availability, and strengthen understanding of sports nutrition and recovery strategies, in dance students of mixed genders.Material and methodsA total of 125 dance students received three workshops, with 39 arts and crafts students serving as references. The results were evaluated by the Eating Disorder Examination questionnaire, the Low Energy Availability in Females questionnaire, the Hopkins Symptom Check List, and questions on mental health literacy, sports nutrition, and recovery knowledge.ResultsDance students achieved sustained improvements in mental health and nutrition knowledge and temporary improvements in driven exercise (i.e., performing exercise because of a compulsive drive). No other benefits were identified from the intervention.ConclusionOur findings indicate the need for an ongoing education program to reduce the occurrence and development of negative mental health outcomes and low energy availability in professional dance students. Such approaches may not only improve the mental health of dance students but also potentially prevent the high frequency of injuries.
Relationships of Cuproptosis-Related Genes With Clinical Outcomes and the Tumour Immune Microenvironment in Hepatocellular Carcinoma
Authors: Chen Xi , Hu Gang , Xiong Li , Xu Qingqing 
Published: September 2022

Background: Cuproptosis is a recently identified form of regulated cell death that plays a critical role in the onset and progression of various cancers. However, the effects of cuproptosis-related genes (CRGs) on hepatocellular carcinoma (HCC) are poorly understood. This study aimed to identify the cuproptosis subtypes and established a novel prognostic signature of HCC.Methods: We collected gene expression data and clinical outcomes from the TCGA, ICGC, and GEO datasets, analysed and identified 16 CRGs and the different subtypes of cuproptosis related to overall survival (OS), and further examined the differences in prognosis and immune infiltration among the subtypes. Subtypes-related differentially expressed genes (DEGs) were employed to build a prognostic signature. The relationship of the signature with the immune landscape as well as the sensitivity to different therapies was explored. Moreover, a nomogram was constructed to predict the outcome based on different clinicopathological characteristics.Results: Three cuproptosis subtypes were identified on the basis of 16 CRGs, and subtype B had an advanced clinical stage and worse OS. The immune response and function in subtype B were significantly suppressed, which may be an important reason for its poor prognosis. Based on the DEGs among the three subtypes, a prognostic model of five CRGs was constructed in the training set, and its predictive ability was validated in two external validation sets. HCC patients were classified into high and low-risk subgroups according to the risk score, and found that patients in the low-risk group showed significantly higher survival possibilities than those in the high-risk group (p &lt; 0.001). The independent predictive performance of the risk score was assessed and verified by multivariate Cox regression analysis (p &lt; 0.001). We further created an accurate nomogram to improve the clinical applicability of the risk score, showing good predictive ability and calibration. Low- and high-risk patients exhibit distinct immune cell infiltration and immune checkpoint changes. By further analyzing the risk score, patients in the high-risk group were found to be resistant to immunotherapy and a variety of chemotherapy drugs.Conclusion: Our study identified three cuproptosis subtypes and established a novel prognostic model that provides new insights into HCC subtype prognostic assessment and guides more effective treatment regimens.
Revealing a Phenotypical Appearance of Ibrutinib Resistance in Patients With Chronic Lymphocytic Leukaemia by Flow Cytometry
Authors: Takács Ferenc , Kotmayer Lili , Czeti Ágnes , Szalóki Gábor , László Tamás , Mikala Gábor , Márk Ágnes , Masszi András , Farkas Péter , Plander Márk , Weisinger Júlia , Demeter Judit , Fekete Sándor , Szerafin László , Deák Beáta Margit , Szaleczky Erika , Sulák Adrienn , Borbényi Zita , Barna Gábor 
Published: September 2022

Background: Ibrutinib is widely known as an effective and well-tolerated therapeutical choice of the chronic lymphocytic leukaemia (CLL). However, acquired resistance may occur during the treatment, causing relapse. Early detection of ibrutinib resistance is an important issue, therefore we aimed to find phenotypic markers on CLL cells the expression of which may correlate with the appearance of ibrutinib resistance.Methods: We examined 28 patients’ peripheral blood (PB) samples (treatment naïve, ibrutinib sensitive, clinically ibrutinib resistant). The surface markers’ expression (CD27, CD69, CD86, CD184, CD185) were measured by flow cytometry. Furthermore, the BTKC481S resistance mutation was assessed by digital droplet PCR. Moreover, the CLL cells’ phenotype of a patient with acquired ibrutinib resistance was observed during the ibrutinib treatment.Results: The expression of CD27 (p = 0.030) and CD86 (p = 0.031) became higher in the clinically resistant cohort than in the ibrutinib sensitive cohort. Besides, we found that high CD86 and CD27 expressions were accompanied by BTKC481S mutation. Our prospective study showed that the increase of the expression of CD27, CD69 and CD86 was noticed ahead of the clinical resistance with 3 months.Conclusion: Our study suggests that the changes of the expression of these markers could indicate ibrutinib resistance and the examination of these phenotypic changes may become a part of the patients’ follow-up in the future.
Covid-19 Pandemi Sürecinde Bireylerin Sağlık Kaygılarının Siberkondri Üzerindeki Etkisi
Authors: DOĞANYİĞİT Pelinsu Buket , KEÇELİGİL Hasan Tahsin 
Published: September 2022

Giriş ve Amaç: Son yıllarda dünya çapında yeni koronavirüs hastalığının (COVID-19) ortaya çıkmasıyla birlikte, bireyler kaygılarını azaltmak için sağlıklarıyla ilgili konularda internetten arama yapmaktadırlar. Bu çalışma, COVID-19 pandemi sürecinde bireylerin sağlık kaygıları ile siberkondri düzeyleri arasında ilişkiyi ve sağlık kaygısının siberkondri düzeyine etkisini incelemeyi amaçlamaktadır.
Gereç ve Yöntemler: Çalışmada veri toplama aracı olarak; Siberkondri Ciddiyet Ölçeği Kısa Formu, Sağlık Anksiyetesi Ölçeği ve katılımcıların sosyo-demografik özelliklerinin ve hekim/hastane seçiminde interneti kullanma durumu, COVID-19’un belirtileri hakkında bilgi sahibi olma durumu vb. gibi soruların yer aldığı bir anket formu kullanılmıştır. Araştırma çevrimiçi anket kullanılarak Samsun il merkezinde yaşayan 384 birey üzerinde gerçekleştirilmiştir. Tanımlayıcı istatistiksel yöntemler, korelasyon ve regresyon analizleri verilerin analizinde kullanılmıştır. Sonuçlar, %95 güven aralığında, p
Dependence of physical qualities on aerobic and anaerobic body productivity in women aged 25-35
Authors: Miroshnichenko Viacheslav , Bohuslavska Viktoriia , Shvets Oksana , Hubar Ivan 
Published: September 2022

Мета дослідження: Виявити зв'язки показників функціональної підготовленості із показниками фізичної підготовленості у жінок 25-35 років.
Матеріал і методи. У дослідженні взяли участь 392 особи жіночої статі віком 25-35 років. Функціональну підготовленість визначали за показниками анаеробної алактатної, анаеробної лактатної та аеробної продуктивності організму. Потужність аеробних процесів енергозабезпечення досліджували за показником максимального споживання кисню. Визначали показник максимального споживання кисню використавши велоергометричний варіант тесту. Поріг анаеробного обміну визначали за тестом із ступінчасто зростаючим навантаженням на велоергометрі. Для визначення ємності анаеробних лактатних процесів енергозабезпечення визначали максимальну кількість зовнішньої механічної роботи за 1 хв. Потужність анаеробних алактатних та лактатних процесів енергозабезпечення визначали за допомогою 10-секундного і 30-секундного Вінгатського анаеробного тесту. Фізичну підготовленість визначали за тестами які характеризують усі фізичні якості або їх поєднання.
Результати. Серед показників аеробної продуктивності найвищий ступінь кореляції виявлено між відносним показником максимального споживання кисню та результативністю бігу на 2000 м (r=-0.6833); відносним показником порогу анаеробного обміну та результативністю бігу на 2000 м (r=-0.6003). Показники анаеробної продуктивності найбільше корелюють із силою правої і лівої кисті. Ступінь кореляції при цьому не перевищує «помітний».
Висновки. Між показниками функціональної підготовленості та показниками фізичної підготовленості у жінок 25-35 років які не мали досвіду занять спортом не виявлено кореляції «високого» та «дуже високого» ступеня. За рівнем розвитку показників фізичної підготовленості не можливо зробити об’єктивні висновки про функціональну підготовленість жінок 25-35 років. На ступінь кореляції впливають методи застосовані для визначення показників фізичної та функціональної підготовленості, вік і стать досліджуваних, рівень спортивної майстерності та обраний вид рухової активності.
Penyuluhan sadari dalam pencegahan kanker payudara di smk swasta kesehatan nap’siah stabat kabupaten langkat
Authors: Dewiwati Tri Suci , Nurhasanah Nurhasanah 
Published: September 2022

Kanker payudara menimbulkan rasa takut yang luarbias bagi kaum perempuan, selain keganasannya yang tanpa ampun, kanker ini kerap datang tiba-tiba tanpa permisi.Kanker ini menduduki peringkat kedua setelah kanker leher rahim di antara kanker yang menyerangwanita Indonesia.Organisasi Kesehatan Sedunia (WHO) melaporkan, padatahun 1989 terdapat 7 juta penderita baru setiap tahun dan 5 juta orang meninggal akibatkan kerpayudara.Secara global dalam 15 tahun terakhir ini frekuensi penderita kanker payudara semakin meningkat, terutama di negara maju (Eropa/Amerika/pada golongan wanita dengan status sosial ekonomi yang tinggi).Di Indonesia problem kanker payudara menjadi lebih besar lagi karena lebih dari 70% penderita datang ke dokter pada stadium yang sudah lanjut, akan hal ini berbeda dengan di negeri maju di Jepang misalnya kanker payudara lanjut hanya ditemukan sebanyak 13% saja.Tidak semua benjolan di payudara adalah kanker, sehingga untuk memastikannya, setiap benjolan perlu diperiksa dengan seksama.Menurut badan kesehatan dunia WHO satu-satunya cara yang efektif sampai saat ini hanya dengan melakukan deteksi sedini mungkin pada kemungkinan timbulnya penyakit ini, yaitu dengan melakukan SADARI (”pemeriksaan payudara sendiri”).
Synthesis of lithium- and pyridine-intercalated superconductors Li
x
(C5H5N)
y
SnSe2
Authors: Sakamoto Chika , Noji Takashi , Kawamata Takayuki , Kato Masatsune 
Published: September 2022

Abstract
Superconductors Li
x
(C5H5N)
y
SnSe2 (x = 0.3–1.0) have been successfully synthesized by the intercalation of pyridine molecules together with Li+ ions into an insulator SnSe2 with the layered structure. The co-intercalation has been carried out by immersing powdery SnSe2 and Li metal in the organic solvent pyridine at 70 °C. The spacing between the adjacent Sn layers is expanded from ∼6 to ∼12 Å through the co-intercalation. It has been found that the superconducting transition temperature T
c ∼ 7.5–7.9 K is almost independent of Li-content x(Li) and the superconducting volume fraction has a maximum at x(Li) = 0.5.
Fenomena Pluralisme Agama Dan Budaya Di Indonesia Sebagai Wujud Implementasi Pancasila Sila Ke 3
Authors: Gilang Ramadhan Khomarudin , Tania Putri Naurah , Kusumastuti Erwin 
Published: September 2022

In our country Indonesia there is a state ideology, one of which is the unity of Indonesia which is in the 3rd precept, here we have the right to choose and determine freedom of religion, in Indonesia there are 6 recognized religions namely Islam, Christianity, Hinduism, Buddhism, Catholicism, Konghuchu. In addition, in Indonesia there are thousands of islands and certainly have various cultures and traditions that become typical cirri of the area Differences in religious diversity on the one hand cause divisions among people. This difference on the one hand causes divisions between peoples and people who can trigger national dicentration, in Islamic teachings we are taught mutual tolerance for all aspects, especially to religious people. Tolerance is shown to one of Allah's messengers, the Prophet Muhammad (peace be upon him), with his love and patience for his people the Apostle is able to spread islam in a peaceful way without disturbing the belief of islam in a peaceful way without disturbing the beliefs of others. Indonesia with its plurality has major challenges, especially in religious differences, because Indonesia tends to be vulnerable to the division of religious people that should be able to support the sovereignty of the nation and state.

Di negara kita Indonesia terdapat ideologi negara yang salah satunya adalah persatuan indonesia yang berada di sila ke 3, disini kita berhak memilih dan menentukan kebebasan beragama, di Indonesia terdapat 6 agama yang diakui yaitu islam, kristen, hindu, budha, katholik, konghuchu. Selain itu di Indonesia terdapat ribuan pulau dan pastinya memiliki macam-macam kebudayaan dan tradisi yang menjadi cirri khas dari daerah tersebut Perbedaan keberagaman agama disatu sisi menyebabkan perpecahan antar kalangan umat bergama. Perbedaan ini disatu sisi menyebabkan perpecahan antar kalangan masyarakat dan umat bergama yang dapat memicu disentrigasi nasional, didalam ajaran islam kita diajarkan saling toleransi untuk segala aspek terlebih lagi kepada umat beragama. Sikap toleransi di tunjukan kepada salah satu utusan Allah SWT yaitu nabi Muhammad SAW, dengan rasa cintanya dan sabarnya kepada umatnya Rasullulah mampu untuk menyebarkan agama Islam dengan cara damai tanpa mengganggu kepercayaan agam lain. Indonesia dengan kemajemukannya memliki tantangan besar terutama dalam perbedaan agama, karena Indonesia cenderung rentan dengan perpecahan umat beragama yang seharusya perbedaan itu dapat menompang kedaulatan bangsa dan negara.
Budget Ratcheting pada Realisasi Anggaran Pemerintah Daerah: Studi Kasus pada Sekretariat DPRD Kabupaten Barru
Authors: Rahman Karlina Ghazalah 
Published: September 2022

Masalah keagenan yang timbul di kalangan eksekutif adalah cenderung memaksimalkan utility (self-interest) dalam pembuatan atau penyusunan anggaran APBD karena memiliki keunggulan informasi (asimetri informasi). Sedangkan Masalah keagenan yang timbul dikalangan legislatif (anggota dewan) terjadi dari dua tinjauan perspektif, sebagai principal atas eksekutif dan sebagai agent dengan rakyat (pemilih). Tujuan penelitian ini adalah melihat pengaruh efek ratchet di dalam realisasi anggaran di Sekretariat DPRD di Kabupaten Barru. Metode penelitian yang digunakan adalah metode kuantitatif. Jenis data yang digunakan adalah data sekunder berupa laporan keuangan Sekretariat DPRD Kabupaten Barru. Metode analisis yang digunakan adalah regresi linear berganda. Hasil penelitian menunjukkan bahwa Pendapatan asli daerah memiliki pengaruh terhadap belanja daerah di Sekretariat DPRD Kabupaten Barru. Efek budget ratcheting memiliki pengaruh dalam memperkuat hubungan antara pendapatan asli daerah dan belanja daerah.
The agency problem that arises among executives is that it tends to maximize utility (self-interest) in making or preparing APBD budgets because it has information advantages (information asymmetry). Meanwhile, agency problems that arise among the legislature (councillors) occur from two perspective reviews, as principals over the executive and as agents with the people (voters). The purpose of this study was to look at the influence of the ratchet effect in the realization of the budget at the DPRD Secretariat in Barru Regency. The research method used is quantitative method. The type of data used is secondary data in the form of financial statements of the Barru Regency DPRD Secretariat. The analysis method used is multiple linear regression. The results showed that local revenue has an influence on regional expenditure in the Barru Regency DPRD Secretariat. The effect of budget ratcheting has an influence in strengthening the relationship between local revenues and regional expenditures.
Efektifitas Penerimaan Pajak Kendaraan Bermotor pada Kantor Sistem Administrasi Manunggal di bawah Satu Atap (SAMSAT) Kabupaten Gowa Tahun 2018-2020
Authors: Marlinah Andi 
Published: September 2022

Penelitian ini bertujuan untuk mengetahui efektifitas penerimaan pajak kendaraan bermotor pada Kantor Sistem Administrasi Manunggal di bawah Satu Atap kabupaten Gowa. Data yang digunakan adalah laporan target dan realisasi penerimaan PKB dari tahun 2018 – 2020. Analisis data dengan menggunakan metode statistic deskriptif. Hasil penelitian menunjukkan bahwa rasio efektifitas selama tahun 2018 – tahun 2020 rata-rata tingkat pencapaiannya sebesar 104,22% dari target yang telah ditetapkan, sehingga tergolong Sangat Efektif. Hal ini disebabkan, karena pihak Samsat Kabupaten Gowa sangat aktif dalam memberikan sosialisasi dan proses prosedur pembayaran pajak sudah bagus karena tidak membutuhkan waktu yang lama dalam pengurusan pembayaran pajak kendaraan bermotor

This study aims to find out the effectiveness of motor vehicle tax revenues at the Manunggal Administrative System Office under one roof in Gowa district. The data used is a report on the target and realization of PKB receipts from 2018 – 2020. Data analysis using descriptive statistical methods. The results showed that the effectiveness ratio during 2018 - 2020 averaged an achievement rate of 104.22% of the target that had been set, so it was classified as Very Effective. This is because the Samsat of Gowa Regency is very active in providing socialization and the process of tax payment procedures is good because it does not take a long time in managing motor vehicle tax payments
KESIAPAN PENERAPAN LAPORAN KEUANGAN ORGANISASI NONLABA BERDASARKAN ISAK 35 (Studi Kasus Jemaat GPM Murai Klasis Aru Tengah)
Authors: Kwalepa Elsye , Leunupun Pieter , Persulessy Grace 
Published: September 2022

Tujuan penelitian ini adalah untuk mengetahui Gereja Protestan Maluku Jemaat Murai Klasis Aru Tengah telah Menyusun laporan keuangannya sesuai dengan ISAK 35. Penelitian ini merupakan penelitian metode kualitatif descriptive. Hasil penelitian menunjukkan bahwa Jemaat Murai belum membuat laporan keuangan yang sesuai dengan ISAK 35. Laporan keuangan yang dibuat oleh Jemaat Murai adalah Laporan Realisasi Anggaran Pendapatan dan Belanja Gereja.
The purpose of this study was to determine the Moluccan Protestant Church of the Murai Klasis Aru Tengah Church has its financial statements in accordance with ISAK 35. This research is a qualitative descriptive research method. The results showed that the Murai Congregation had not made financial reports in accordance with ISAK 35. The financial reports made by the Murai Congregation were the Church's Revenue and Expenditure Budget Realization Report.
This research was conducted in the educational context of Sixto Chang Cansing School to help improve the English language teaching and learning process. The fourth graders had a low vocabulary level due to inadequate teaching methods. According to the dat
Authors: Carabajo Romero MSc Italo , Vega Alex Rogel , Quinto Ochoa Edmundo 
Published: September 2022

Esta investigación se realizó en el contexto educativo de la escuela Sixto Chang Cansing para ayudar a mejorar el proceso de enseñanza y aprendizaje del idioma inglés. Los alumnos de cuarto grado tenían un bajo nivel de vocabulario debido al uso de métodos de enseñanza inadecuados. Según los datos obtenidos a través del instrumento de investigación cuantitativa, los profesores preferían utilizar métodos de enseñanza tradicionales como el método de traslación o el método directo. Los cuales no son adecuados para enseñar a los niños.
Para cambiar esta situación desde el punto de vista profesional, se elaboró una guía didáctica basada en un método que considera la edad y las necesidades de los alumnos como la solución más adecuada. El método elegido para trabajar este problema fue el de respuesta física total. Éste combina movimientos físicos y sonidos para facilitar la memorización del vocabulario en la memoria a largo plazo. Durante su aplicación, se pueden utilizar dinámicas y juegos para que los alumnos aprendan en un ambiente divertido y sin estrés. Este método hace que los niños tengan un interés intrínseco, lo que acelera el proceso de aprendizaje.
Unión civil de personas mismo sexo y vulneración del derecho de familia
Authors: Atoche Pacherres Patricia , Barrientos García Manuela , Campos García Dalia Carina , Mejía Fernández Jesús Martin , Atoche Pacherres Cesar Augusto , Rojas Oballe Víctor Raúl 
Published: September 2022

El objetivo es determinar viabilidad de la unión civil entre personas del mismo sexo sin que afecte al matrimonio y la familia en Perú. El tipo de investigación es descriptiva de las características de la unión civil entre homosexuales; además, es histórica porque se investiga sobre la naturaleza jurídica, orígenes de la unión civil, primeros planteamientos y objetivos sobre la unión civil homosexual. Los procedimientos incluyeron revisión de la doctrina y de algunos artículos periodísticos. El diseño de la investigación es documental, porque los datos se obtienen de la revisión de fuentes bibliográficas, normativas, para responder el problema propuesto desde los aportes doctrinarios construidos.
Los resultados indican que, la mayor oposición a la Unión Civil está en varones de 40 a 70 años. La iniciativa de un congresista generó el rechazo de políticos e Iglesia Católica por considerarla como "matrimonio encubierto". Para el año 2017 la mayoría está en desacuerdo con la unión civil y, con la legalización en Perú del matrimonio de personas del mismo sexo realizado en el extranjero. Se concluye que, es imposible regular la unión civil, debido al ordenamiento legal peruano que reconoce al matrimonio como unión voluntaria y concertada de varón y mujer legalmente aptos y formalizada acorde con leyes vigentes, por ser esencialmente heterosexual. La unión civil entre personas del mismo sexo incumple funciones sociales, atenta contra la integridad de la familia y supone un grave daño para la formación de la personalidad de los niños y para la salud mental de la sociedad.