bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constraints Faced and Opinions of Farm Women Regarding Vocational Trainings Conducted under KVK Jeolikote
Authors: Singh Neha , Bhardwaj Neelam , Raj Khusboo , Gupta Mohit 
Published: May 2022

Abstract
Purpose: To analyse the constraint and opinion by women beneficiaries (BF) regarding vocational trainings conducted under KVK Jeolikote Design/Methodology: Applying random sampling technique, 45 BF (by using proportional allocation method) and 45 women non-beneficiaries (NBF) engaged in vocational training from the same area were deeply interviewed using a pre-tested structured interview schedule. Descriptive research design was used for the present investigation. Based on the nature of data, frequency, percentage, arithmetic mean and weighted mean square the weightage of each constraint was calculated and ranked by the researcher.Findings: Majority of respondents 66.66 per cent felt it as improving farm family living and half of the respondents 55.55 per cent found vocational training programmes as means of promoting gender equality. Lack of financial assistance to start own venture or small scale enterprise received the highest weighted mean score of 3.1 and were thus ranked first.Practical Implications: Information regarding constraints and opinion through group activities involving both vocational and horizontal learning helps in eliminating the barriers that restricts the development of farm women.Theoretical Implications: Vocational training provided by Krishi Vigyan Kendra helps majority of the farming community especially to marginal and a small farm woman to gain women empowerment with the acquaintance of new skill, knowledge and attitudes.Originality/Value: This research will provide a thorough understanding of the impact of vocational training provided by KVKs on socio-economic status, trainings skill needed, and level of empowerment after adopting different enterprises. The result of the study may be useful to encourage non-beneficiaries to join Vocational trainings.
An Adaptive Interactional Technique Based on the Five-Dimensional Emotional Model for Webpage Interface Design
Authors: Zhang Hanzhong , Yin Jibin , Qin Haonan 
Published: May 2022

Abstract
The five-dimensional emotional model has been proposed for the recognition of emotions. This paper presents an adaptive emotional technique for webpage interface design based on it, which adaptively adjusts the presentation of various elements of web user interfaces by recognizing the changes in a user’s facial expression. The adjustments in the web interface, in turn, affect the user’s emotions. An experiment was designed and conducted to examine the relationship between interface elements and users’ emotional dimensions. The experimental results showed that there was a significant correlation between the layouts of the web user interfaces and the users’ emotions. Using a multi-layer perceptron, a neural network model was then trained to transform the values of the users’ emotional dimensions and interface element values, and a quantifiable transformation relationship between the webpage elements and users’ emotions was obtained. Finally, design guidelines based on our proposed adaptive technique are provided for web user interfaces.
Role of the Specialized Proresolving Mediator in Amyotrophic lateral sclerosis
Authors: Wei Xiao-jing , Li Xi-xi , Sun Hui , Qiu Ru-qing , Yu Xue-fan 
Published: May 2022

Abstract
Amyotrophic Lateral Sclerosis (ALS) is a devastating progressive neurodegenerative disease that affects motor neurons, leading to a relentless paralysis of skeletal muscles and eventual respiratory failure. Neuroinflammation is one of the hallmarks of ALS and may contribute to motoneurons degeneration. Accumulating evidence suggests that chronic inflammation resulting from insufficient resolution, a process operated by specialized pro-resolving mediators (SPMs). However, whether resolution of inflammation is impaired in ALS is not known. The objective of this study was to investigate the levels of SPMs in the serum and cerebrospinal fluid (CSF) of ALS patients, and to explore the roles of SPMs in clinical features of ALS. Fourty-one patients with ALS, and 73 patients with non-inflammatory neurological diseases were enrolled in this study. Pro-resolving mediators including resolvin D1 (RvD1), maresin 1 (MaR1) and lipoxinA4(LxA4) levels were analyzed using enzyme-linked immunosorbent assay. Pro- and anti-inflammatory cytokines levels were analyzed by cytometric beads array (CBA). Our results showed serum RvD1 levels were decreased, whereas CSF RvD1 levels were significantly increased in ALS patients compared to controls. Serum RvD1 was also negatively correlated to disease progression rate (DPR), and positively correlated with forced vital capacity (FVC). The present preliminary study allows hypothesizing impaired resolution of inflammation in patients with ALS, confirming the emerging role of bioactive lipids in this disease.
Structure-Function characterization of an aldo-keto reductase involved in detoxification of the mycotoxin, deoxynivalenol
Authors: Abraham Nadine , Schroeter Kurt L. , Zhu Yan , Chan Jonathan , Evans Natasha , Kimber Matthew S. , Carere Jason , Zhou Ting , Seah Stephen YK 
Published: May 2022

Abstract
Deoxynivalenol (DON) is a mycotoxin, produced by filamentous fungi such as Fusarium graminearum, that causes significant yield losses of cereal grain crops worldwide. One of the most promising methods to detoxify this mycotoxin involves its enzymatic epimerization to 3-epi-DON. DepB plays a critical role in this process by reducing 3-keto-DON to 3-epi-DON. DepBRleg from Rhizobium leguminosarum is a member of the new aldo-keto reductase family, AKR18, and it has the unusual ability to utilize both NADH and NADPH as coenzymes, albeit with a 40-fold higher catalytic efficiency with NADPH compared to NADH. Structural analysis of DepBRleg revealed the putative roles of Lys-217, Arg-290, and Gln-294 in NADPH specificity. Replacement of these residues by site-specific mutagenesis to negatively charged amino acids compromised NADPH binding with minimal effects on NADH binding. The substrate-binding site of DepBRleg is larger than its closest structural homolog, AKR6A2, likely contributing to its broad specificity towards a range of aldehydes and ketones, including the mycotoxin, patulin. DepBRleg produced 3-epi-DON and DON in diastereomeric ratios of 67.2% and 32.8% respectively. The modeled ternary complex suggests that 3-keto-DON can adopt two binding modes to facilitate 4-pro-R hydride transfer to either the re- or si-face of the C3 ketone.
Mifepristone combined with ethacridine lactate for the third-trimester stillbirth induction: a 5-year experience from Shanghai
Authors: Xue Rui-Hong , Yao Yong-Li , Huang Run-Jie , Ma Jue , Zhang Lin 
Published: May 2022

Abstract
Objective: To explore the efficacy and safety of mifepristone combined with ethacridine lactate for induction of stillbirth in the third-trimester.Methods: All women who had a stillbirth in late pregnancy (≥28 weeks) except for eugenics in an university-based maternity center from September 2016 to September 2021 were included in our study. The methods of induction of stillbirth and their complications were analyzed in different groups.Results: We identified 5-year deliveries in the hospital, 122 women experienced a stillbirth, among whom 38 stillbirths resulted from eugenics induction and were excluded, 84 cases were included in our analyses. We analyzed the methods of induction in these 84 cases, 51(60.71%) cases accepted intra-amniotic ethacridine lactate induction, among whom 48(94.12%) cases had a successful induction. The ethacridine lactate induction group showed no increased risks in complications(5.88%, 3/51), compared with non-ethacridine lactate group(12.12%, 4/33)(P=0.097, OR, 0.27, 95%CI, 0.05 to 1.27). No statistical difference in induction failure was found between different ethacridine dosage groups (P=0.48, OR, 2.46, 95%CI, 0.21 to 28.89).Conclusions: Mifepristone combined with ethacridine lactate is a safe and effective induction method for stillbirth in the third-trimester.
Efficacy and Safety of Over-the-Wire Technique versus Direct Catheter Insertion Technique in Peripherally Inserted Central Venous Catheter Placement: A Randomized-Controlled Study
Authors: Teichgräber Ulf , Kasikci Deniz , Mack Verena 
Published: May 2022

Abstract
Purpose To assess the effectiveness and safety of the over-the-wire (OTW) technique as compared to the direct catheter insertion (DCI) technique in ultrasound (US) guided peripherally inserted central venous catheter (PICC) placement with fluoroscopic catheter tip location.Methods In a non-inferiority randomized-controlled study, 60 PICCs were implanted by an interventional radiologist into the basilic, cephalic, or brachial vein of the mid-upper arm. The effectiveness as primary endpoint was measured by implantation time. Placement accuracy was detected as secondary endpoint by tip location under chest x-ray, whereas safety was measured by the rate of periprocedural and early complications occurring within two weeks. Results Implantation time of 8.34 ± 2.14 minutes applying the OTW technique showed to be significantly more time-consuming than DCI technique with 5.530.96 minutes (p<0.001). The results for the secondary endpoints were not allowing a statistically significant statement due to the patient number. The exploratory analysis showed however no significant difference (p=0.3) regarding tip placement accuracy between both insertion techniques (optimal tip localization of 100% with the DCI technique; 97% with the OTW technique). Periprocedural bleeding events from the introducer occurred in 26.7% of the patients with OTW technique towards not considerable bleeding in the DCI group (p=0.003). Conclusion For US-guided fluoroscopic PICC insertion in adults, the DCI technique was superior as compared to the OTW technique in terms of procedure time.Trial registration NCT 04303052
Serum biomarker panel diagnostics in pancreatic ductal adenocarcinoma: the clinical utility of soluble interleukins, IFN-γ, TNF-α and PD-1/PD-L1 in comparison to established serum tumor markers
Authors: Dorman Klara , Gerckens Miriam , Kruger Stephan , Krueger Kimberly , Mayer Zsuzsanna , Rupp Alexander , Zhang Danmei , Weiss Lena , Westphalen C. Benedikt , Haas Michael , Guenther Michael , Ormanns Steffen , Klawonn Frank , Werner Jens , Bergwelt-Baildon Michael , Heinemann Volker , Boeck Stefan , Holdenrieder Stefan 
Published: May 2022

Abstract
Purpose
Novel biomarkers to better predict outcome and select the best therapeutic strategy for the individual patient are necessary for pancreatic ductal adenocarcinoma (PDAC).
Methods
Using a panel assay, multiple biomarkers (IFN-γ, IL-10, IL-6, IL-8, TNFα, CEA, CA 199, CYFRA 21 − 1, HE4, PD-1 and PD-L1 levels) were measured in serum samples of 162 patients with resected, locally advanced and metastatic PDAC in this retrospective single-center study. Optimal cut-off values to differentiate prognostic subgroups with significantly different overall survival (OS) were determined by receiver operator characteristics and Youden Index analysis. Marker levels were assessed before start of chemotherapy and correlated with OS by univariate and multivariate Cox analysis.
Results
Median OS for resected patients was 28.2 months, for locally advanced patients 17.9 months and for patients with metastatic disease 8.6 months. CYFRA 21 − 1 and IL-8 discriminated metastatic from locally advanced patients best (AUC 0.85 and AUC 0.81, respectively). In univariate analyses, multiple markers showed prognostic relevance in the various subgroups. However, multivariate Cox models comprised only CYFRA 21 − 1 in the resected group (HR 1.37, p = 0.015), IL-10 in locally advanced PDAC (HR 10.01, p = 0.014), as well as CYFRA 21 − 1 and CA 19 − 9 in metastatic PDAC (p = 0.008 and p = 0.010) as independent prognostic marker for overall survival.
Conclusion
IL-10 levels may have independent prognostic value in locally advanced PDAC, whereas CYFRA 21 − 1 levels are prognostic after PDAC surgery. CYFRA 21 − 1 and IL-8 have been identified to best discriminate metastatic from locally advanced patients.
Finite element analysis of zero-crossing temperature of long Fabry-Perot cavity
Authors: Shang Junjuan , Zhu Xianwei , Ma Junya , Song Hongfang , Zhou Peilin , Hu Jiandong , Yuan Zhihua , Zhang Mengjiao 
Published: May 2022

Abstract
A Fabry-Perot (F-P) cavity with a low thermal noise limit 7.8×10-17 is investigated. The spacer aperture is composed of three holes, where a long and small hole in the middle, a shorter and larger hole on each side. The FS mirrors are placed in the larger holes of the spacer aperture, the FS rings are mounted on the end face of the spacer, and FS mirrors, aperture and FS rings are coaxial. It enables the cavity zero-crossing temperature easily tuning to above room temperature. In the meantime, with this design the machining error has little effect on the zero-crossing temperature of the cavity. In addition, it is convenient for manufacturing of long F-P cavity.
Remimazolam besylate for the sedation of postoperative patients with invasive mechanical ventilation in the ICU: a prospective dose-response study
Authors: Chen Xiaoyan , Zhang Jiancheng , Yuan Shiying , Huang Haiyan 
Published: May 2022

Abstract
Background: This single-center study aims to determine the effective dose and safety of remimazolam besylate for the sedation of postoperative patients with invasive mechanical ventilation in the intensive care unit (ICU). Methods: Mechanically ventilated patients admitted to the ICU after surgery were included. The Narcotrend index (NTI) was used to assess the depth of sedation, and the Richmond Agitation-Sedation Scale (RASS) was also recorded. Remimazolam besylate was administered initially at a loading dose of 0.02 mg/kg, followed by a gradual increase of 0.005 mg/kg each time until targeted depth of sedation was achieved (NTI 65–94). A maintenance dose of remimazolam besylate was administered starting at 0.2 mg/kg/h, followed by increments or subtractions of 0.05 mg/kg each time until a satisfactory depth of sedation was achieved and maintained for at least 30 minutes. The demographic data, anesthesia, surgery types, hemodynamics and respiratory parameters were recorded. Results: Twenty-three patients were included for this study eventually over a year. A satisfactory depth of sedation could be achieved by a single intravenous infusion of remimazolam besylate at a loading dose of 0.02–0.05 mg/kg followed by a pump maintenance dose of 0.20–0.35 mg/kg/h. There were no significant changes in hemodynamic and respiratory parameters within 10 minutes after administration of remimazolam besylate. In addition, a significant correlation was observed between NTI and RASS for assessing sedation (r = 0.721, P＜0.001). NTI showed a prediction probability of RASS score of 0.817. Conclusions: Remimazolam besylate was effective for mild/moderate sedation of postoperative invasively mechanically ventilated patients in ICU, while maintaining excellent respiratory and hemodynamic stability. The NTI could be used as a good tool for the objective evaluation of the depth of sedation and agitation. Trial registration: ChiCTR2100043752. Retrospectively registered 27 February 2021.
Microbiome network in the pelagic and benthic offshore systems of the northern Adriatic Sea (Mediterranean Sea)
Authors: Scicchitano Daniel , Martire Marco Lo , Palladino Giorgia , Nanetti Enrico , Fabbrini Marco , Dell'Anno Antonio , Rampelli Simone , Corinaldesi Cinzia , Candela Marco 
Published: May 2022

Abstract
BackgroundBecause of their recognized global importance, there is now the urgent need to map diversity and distribution patterns of marine microbial communities. Even if available studies provided some advances in the understanding the biogeographical patterns of marine microbiomes at the global scale, their degree of plasticity at the local scale it is still underexplored, and functional implications still need to be dissected. In this scenario here we provide a synoptical study on the microbiomes of the water column and surface sediments from 19 sites in a 130 km2 area located 13.5 Km afar from the coast in the North-Western Adriatic Sea (Italy), providing the finest-scale mapping of marine microbiomes in the Mediterranean sea. Results Pelagic and benthic microbiomes in the study area showed sector specific-patterns and distinct assemblage structures, corresponding to specific variations in the microbiome network structure. While maintaining a balanced structure in term of provided ecosystem services (e.g., hydrocarbon degradation and nutrient cycling), sector-specific patterns of over-abundant modules - and taxa - were defined, with the South sector (the closest to the coast) characterized by microbial groups of terrestrial origins, both in the pelagic and the benthic realms. Conclusions By the granular assessment of the marine microbiome changes at the local scale, we have been able to highlight the admission of terrestrial microorganisms in the marine microbiome networks, as a possible natural process characterizing eutrophic coastal area. This raises the question about the biological threshold for terrestrial microorganisms to be admitted in the marine microbiome networks, without disturbing the ecological balance.
Clinical features of resected gastric neuroendocrine neoplasms
Authors: Ito Shunichi , Taniguchi Kiyoaki , Suzuki Kazuomi , Egawa Hiroto 
Published: May 2022

Abstract
Background: Due to improvements in diagnostic technology, the incidence of gastrointestinal neuroendocrine neoplasms has increased gradually. Therefore, it is important to understand their clinical manifestations and management. The aims of this study were to investigate the clinical features of gastrointestinal neuroendocrine neoplasms and to evaluate the outcomes of patients in our institute.Methods: Between April 1965 and December 2020, patients with a diagnosis of gastric neuroendocrine neoplasms undergoing surgery in our institute were recruited. Clinical data were collected retrospectively.Results: Twenty-four gastric neuroendocrine neoplasm patients were recruited. Ten patients had lymphovascular invasion and seven patients had lymph node metastasis. There was a significant difference in the overall survival rate between those with and without lymph node metastasis. The significant risk factor for lymph node metastasis was lymphatic invasion.Conclusions: Positive lymph node metastasis influenced overall survival. Lymphatic invasion was the most important risk factor for lymph node metastasis.
Low MAGI3 expression promotes Wnt/β-catenin signaling to mediate metastasis and rapalogs resistance of clear cell renal cell carcinoma
Authors: HE JUNQI , Gu Siyu , Liu Hua , Zhang Lijie , Lu Wenxiu , Zhao Chunjuan , Fa Pengyan , Wang Haibo , Cao Xuedi , Yang Yang , Yang Ying , Qin Qiong , Yang Xiaomei , Song Ran , Huang Lian , Feng Duiping 
Published: May 2022

Abstract
Metastatic renal cell carcinoma (mRCC) is considered a fatal malignancy with poor overall survival, but the efficacy of the currently available strategies is limited. Hence, a better understanding of the detailed mechanisms behind the pathogenesis of RCC and more effective treatment strategies were urgently required. In this study, we found that MAGI3 was low-expressed, and associated with metastasis of ccRCC by screening and validating from multi-central cohorts. Low MAGI3 level was correlated with advance stage, grade and poor survival of ccRCC in several independent cohorts, revealing that MAGI3 might be employed as a biomarker in predicting prognosis of ccRCC. By both ectopic expression and knockdown of MAGI3 assays, we found that MAGI3 could inhibit the migration, invasion, and metastasis of ccRCC cells in vitro and in vivo. Mechanistically, we revealed that the C-tail of β-catenin binding with MAGI3 facilitated its N-tail to release from intramolecular interaction of β-catenin, and reinforced the association between β-catenin and GSK-3β, thereby, promoted GSK3β-mediated β-catenin phosphorylation, and ubiquitin-proteasome degradation, subsequently attenuates Wnt/β-catenin activation in ccRCC. Our results also demonstrated that MAGI3 conferred ccRCC cell sensitivity to Everolimus through Wnt/β-catenin pathway, and the combination of Wnt inhibitors synergistically increased the sensitivity of ccRCC cells to rapalogs. Therefore, this is a first report of a synthetic lethal interaction between inhibition of mTOR/AKT and Wnt/β-catenin pathway in ccRCC, revealing a new therapeutic approach for the treatment of advanced ccRCC patients by combined therapy of mTOR inhibitors (rapalogs) with Wnt inhibitors or upregulation of MAGI3 expression.
α2-Fraction and Haptoglobin as Biomarkers for Disease Activity in Oligo- And Polyarticular Juvenile Idiopathic Arthritis
Authors: Zeller Ludwig , Tyrrell Pascal N , Wang Stella , Fischer Nadine , Haas Johannes-Peter , Hugle Boris 
Published: May 2022

Abstract
Objectives: Unlike in adult rheumatology, for most forms of juvenile idiopathic arthritis (JIA) no reliable biomarkers currently exist to assess joint and disease activity. However, electrophoresis is frequently found changed in active juvenile arthritis. The objective of this study was to evaluate the α2-fraction of serum electrophoresis and its main components as biomarkers for JIA, categories extended/persistent oligoarthritis and seronegative polyarthritis, in comparison with the conventionally used erythrocyte sedimentation rate and C-reactive protein. Methods: Serum samples and clinical data from 181 patients with JIA were collected. Serum electrophoresis and α2-fraction and its components were determined using standard methods. Relationship between calculated α2-fraction of serum electrophoresis (CA2F) and its components, acute-phase parameters and cJADAS27 was assessed using Pearson’s correlation coefficient and linear regression modelling, adjusting for confounding effects. Results were confirmed in a second cohort with 223 serum samples from 37 patients, using a mixed model to account for repeated measures.Results: Compared to ESR and CRP, CA2F showed higher correlation to cJADAS27, in particular for persistent oligoarthritis. Of the three components of the α2-fraction, haptoglobin showed the highest correlation to cJADAS27. Regression analysis demonstrated higher ability to predict cJADAS27 for CA2F, and especially for haptoglobin as a component thereof, than for CRP and ESR. Conclusion: Compared to conventional methods, α2-fraction of serum electrophoresis and specifically, haptoglobin show higher correlations with disease activity in common subtypes of JIA, representing excellent candidates as biomarkers for disease activity. Further studies are necessary to determine diagnostic value and correlations in other subtypes.
Key Drivers Influencing Tribal Communities to become Open Defecation Free: Case of Dantewada District, Chhattisgarh in India
Authors: Pathak Paritosh , Adlakha Amit , Pandey Prashant , Kaur Divneet 
Published: May 2022

Abstract
The Swachh Bharat Mission has been successful in improving the sanitation condition across the nation in a very short span of time. The key approach adopted by the Government of India (GOI) was primarily Community Led Total Sanitation (CLTS) also termed as Community Approached to Total Sanitation (CATS). This paper attempts to identify the key drivers behind collective behaviour change of the tribal communities in Dantewada district of Chhattisgarh. In the study 102 respondents were selected randomly and interviewed across different open defecation free (ODF) villages through a questionnaire. The data was then analysed through SPSS which reveals that Supportive Environment, Institutional and Social Support, Personal Necessity, Issues with Open Defecation, Enhanced Awareness and Social Enforcement are the key drivers in improving the sanitation condition and making the district open defecation free. The study has practical policy implications which can help the implementing bodies to work for this cause more effectively.