bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rhabdoid renal tumor: an aggressive embryonal tumor in an infant — a case report
Authors: Habachi Ghada , Sahli Sondes , Ammar Sabrine Ben , Jouini Riadh 
Published: September 2022

Abstract
Background
Malignant rhabdoid tumor of the kidney is the most aggressive childhood renal tumor. A preoperative diagnosis is critical in order to correctly establish a therapeutic strategy and a full metastatic workup.

Case presentation
We report on a 3-month-old case with fever, diarrhea, and abdominal distension treated surgically with adjuvant chemotherapy. The diagnosis was confirmed postoperatively. Relapse was quick, and the child died 5 months after surgical resection.

Conclusions
Rhabdoid renal tumor in young age is associated with a high mortality rate even with invasive strategies. Case reports and research are critical for evaluating existing protocols and improving prognosis. Diverse clinical trials are being conducted in the hopes of improving the prognosis of rhabdoid renal tumors.
PPI efficacy in the reduction of variceal bleeding incidence and mortality, a meta-analysis
Authors: Elseidy Sheref A. , Sayed Ahmed , Awad Ahmed K. , Mandal Debvarsha , Mostafa Mariam , Adigun Aisha , Vorla Monica , Zamani Zarlakhta , Iqbal Amir 
Published: September 2022

Abstract
Objective
To review the efficacy and safety of proton pump inhibitors (PPIs) in gastroesophageal varices (GEVs).

Methods
We searched PubMed MEDLINE, Scopus, and Web of Science for studies that measured the effect of PPI for prophylaxis and treatment of post-band ligation ulcers up to July 20, 2021. We included studies that measured the effect of PPI as treatment or prophylaxis for post-band ligation ulcers; articles that were published in peer-reviewed international journals and had enough data for qualitative and quantitative analysis were included with no language restriction. Heterogeneity was evaluated using the inconsistency (I2) and chi-squared (χ2) test. I2 > 50% was considered substantial heterogeneity in the studies, and a P value less than 0.05 was considered statistically significant. The data was continuous, and we used the standardized mean difference (MD) and risk ratio (RR) with a 95% confidence interval to assess the estimated effect measure.

Results
A total of 7 studies with 2030 patients were included in our study of which 1480 participants were males (72%) and 550 females (18%). Mean age was 59.7 years old. Rebleeding post-band ligation was compared between PPI and placebo with significant favor for PPI (p = 0.00001). The pooled risk ratio was 0.53 (95% CI of 0.41, 0.68); furthermore, bleeding-related death at a 1-month period was compared between PPI and placebo with significant favor for PPI (p = 0.00001). The pooled risk ratio was significant at 0.33 (95% CI of 0.20, 0.53). The length of hospital stay postoperative was compared between PPI and placebo with cumulative mean difference of 0.13 (95% CI of −1.13, 1.39), yet without significance.

Conclusions
The study suggests a twofold reduction in the risk of bleeding and a threefold reduction in the risk of bleeding-related death with the use of PPI following EVL.
Does pathological type of primary nephrotic syndrome affect serum concentrations of proprotein convertase subtilisin/kexin type 9?
Authors: Shinnawy Howayda El , Fahmy Abubakr Mohamed , Gharib Mohamed Sary 
Published: September 2022

Abstract
Background
Dyslipidemia is a common finding in primary nephrotic syndrome (PNS). Serum PCSK9 level is also increased in PNS and is the main cause of dyslipidemia in such patients. There is a paucity of data on the relation between dyslipidemia and pathological types of PNS. We hypothesized that severity of dyslipidemia varies across different types of PNS, and this variation is due to differences in serum PCSK9 levels.

Methods
Fifty patients recently diagnosed with PNS were included in this cross-sectional study. Serum PCSK9, albumin, creatinine, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), very low-density lipoprotein cholesterol (VLDL-C), triglycerides (TG), and 24-h urine protein were measured. Comparison of patients’ characteristics between pathological types of PNS and correlations between serum PCSK9 and other parameters were assessed.

Results
Serum PCSK9 levels were significantly higher in PNS patients compared with healthy individuals (314.58 ± 73.83 vs 253.42 ± 36.66 ng/ml, p < 0.001). No differences found between PNS types regarding serum levels of PCSK9 (p = 0.571), TC (p = 0.806), LDL-C (p = 0.950), HDL-C (p = 0.844), VLDL-C (p = 0.472), and TG (p = 0.969). Serum PCSK9 levels correlated significantly with TC (p < 0.001), LDL-C (p < 0.001), HDL-C (p = 0.003), VLDL-C (p = 0.008), TG (p = 0.005), 24-h urine protein (p = 0.005), and male sex (p = 0.014).

Conclusion
The pathological type of PNS does not affect serum levels of PCSK9 and components of lipid profile.
An unusual case of lymphoma — a case of extranodal NK/T-cell lymphoma, nasal type
Authors: Mankgele Mahlatse , Goqwana Lindokuhle , Philip Vinitha , Waja Faadil , Lakha Atul , Perner Yvonne , Patel Moosa 
Published: September 2022

Abstract
Background
There is a great geographic variation of extranodal natural killer (NK)/T-cell lymphoma, nasal type (NNKTL) prevalence, with a much higher prevalence in the Asian and South American populations. According to our knowledge and searches, only one other case report/study of NNKTL has been published in South Africa.

Case presentation
We present a southern-African 31-year-old male residing in a township in the south of Johannesburg, South Africa. He presented with signs and symptoms similar to those of benign upper airway diseases. Further work-up of persisting signs and symptoms yielded a diagnosis of NNKTL. He was treated with the SMILE (steroids — dexamethasone, methotrexate, ifosfamide, L-asparaginase and etoposide) chemotherapy regimen, and sandwich radiotherapy was planned. He had a partial response to chemotherapy but unfortunately demised due to overwhelming sepsis prior to radiation therapy.

Conclusion
Making a diagnosis of NNKTL in resource-limited settings is challenging as the diagnosis requires not only the demonstration of NK-cell markers but also to have a positive Epstein-Barr virus (EBV) in situ hybridization (EBER-ISH). Collaboration of smaller centres with larger and better equipped centres is required to diagnose and document NNKTL more accurately in the African setting.
Endoscopic ear surgery: then and now, review article
Authors: Moneir Waleed , Elkahwagi Mohamed 
Published: September 2022

Abstract
Objective
Endoscopic ear surgery (EES) is a growing and well-recognized field in the modern era. EES had a stepwise journey of development. This journey is pretty comparable to the endoscopic sinus surgery development.

Methods
Online literature search was performed to give a concise review on the development and recent applications of EES and in addition to clarify the reported advantages and disadvantages of EES.

Results
EES has a more recent application than ESS that started decades after endoscopic sinus surgery (ESS). The use of endoscope in ear surgery gives a wide-angled detailed view of the middle ear structures. It gives the ability to look around the corners offering less disease persistence than the microscopic approaches. EES is useful in cases of narrow and angled external auditory canal as it bypasses the narrowest segment of EAC. However, it lacks the 3D perception and enables one hand surgery which could be difficult to manage bleeding. Applications of EES extended from tympanoplasty, stapedotomy, cholesteatoma surgery, and middle ear ventilation in chronic inflammatory conditions to the neurotologic applications in lateral skull base surgery.

Conclusion
EES is an extremely growing field with many applications in otology and neurotology. The advantages of endoscopic applications outweigh the disadvantages. It has a stepwise learning curve and offer better teaching ability.
Demographic and clinical criteria of intranasal lobular capillary hemangioma: as retrospective multicentric audit
Authors: Al-Ani Raid M. , Bargas Omar M. 
Published: September 2022

Abstract
Introduction
Lobular capillary hemangioma (LCH) is a benign vascular tumor that rarely affects the nasal cavity. Pregnancy and previous nasal trauma or surgery might be implicated in the pathogenesis of this tumor. However, in the majority of the cases, there is no identified cause. The objective of this study was to characterize the numerous demographic and clinical aspects of intranasal LCH and to find whether there is a link between its likely causation and other parameters. We retrospectively reviewed the medical records (from 2012 to 2021) of subjects with proven cases of intranasal LCH on histopathological evaluation at four main hospitals in Baghdad, Ramadi, Tikrit, and Samawah cities, Iraq. The detailed information concerning the age, gender, duration, clinical features, side, location, type of anesthesia, follow-up period, and recurrence was registered for each participant.

Results
Of the 82 patients, there were 73.2% females. The majority of the cases (79.3%) were from the age group of 18–40 years. The majority of the patients (74.4%) were seen within 1–2 months. Most of the cases originated from the left side (59.8%) and the nasal septum (81.7%). Epistaxis was the most common presenting symptom (91.5%). No cause was identified in 42.7% of the cases, followed by pregnancy (31.7%) and trauma (25.6%). There was a significant difference between the possible cause and the age and gender (P-value = 0.000). The recurrence rate was 3.66%.

Conclusion
Intranasal LCH shows a female predominance and mostly affects the age group of 18–40 years. Most of the cases involved the left side and nasal septum. Epistaxis was the chief complaint in the majority of cases. Age and gender can determine the possible cause of the lesion.
Thyroid abscess in a human immunodeficiency virus-infected patient
Authors: Damoune I. , Akioud F. , Cherrabi K. , Benhommad O. , Ajdi F. 
Published: September 2022

AbstractBackgroundThyroid abscess is a rare entity and occurs in patients in a particular situation either in an immunocompromised patient or on tuberculosis infection since the African countries are still tuberculosis endemic countriesCase presentationWe report the case of a 38-year-old female patient who has a thyroid abscess caused byCitrobacterwhich is a rare germ. Screening for human immunodeficiency virus (HIV) was positive for HIV infection.ConclusionsScreening for HIV and other causes of immunosuppression should be considered in any patient with thyroid abscess.
Blood and sputum eosinophilia in COPD exacerbation
Authors: Helala Laila Ashour , AbdelFattah Eman Badawy , Elsalam Hazem Mohamed Abd 
Published: September 2022

Abstract
Background
Exacerbations in chronic obstructive pulmonary disease (COPD) are major contributors to worsening lung function, impaired quality of life, emergency healthcare use, and COPD-related mortality. COPD exacerbations are heterogeneous in terms of airway inflammation and etiology.

Objectives
To assess the relation between blood and sputum eosinophils and COPD exacerbation.

Subjects and methods
Prospective cohort study, conducted on 100 COPD patients presented in outpatient clinic. All patients were subjected to medical history including: occupational history, smoking history, comorbidity, number of exacerbations in last year and their degree, history of admission in the last year and treatment taken for COPD. Modified Medical Research Council scale of dyspnea, peak expiratory flow rate, oxygen saturation using pulse oximetry. Complete blood count with differential eosinophilic count. Sputum sample differential cell count was done.

Results
The eosinophil level in blood before and after treatment showed a significant positive correlation with the number of hospital admission in the last year (r = 0.29; P = 0.003 and r = 0.3; P = 0.002, respectively). Regarding the eosinophil level either in blood or in sputum, it showed significant statistical elevation in patients not using steroid treatment in comparison to patients who used systemic or inhaled steroid treatments (P < 0.001 and 0.004, respectively).

Conclusion
Blood eosinophil count can be used as a severity marker of COPD exacerbations. The eosinophil levels, either in blood or sputum, were significantly correlated with the degree of exacerbation. Sputum eosinophilia can also predict the risk of hospitalization. In addition, blood eosinophil count can direct the use of oral corticosteroids in exacerbation.
The importance of market signals in crop varietal development: lessons from Komboka rice variety
Authors: Ng’endo Mary , Kinyua MaryLiza , Chebet Lourine , Mutiga Samuel , Ndung’u Joseph , Nyongesa Oliver , Njau Simon , Panchbhai Ajay , Musila Ruth , Murori Rosemary 
Published: September 2022

AbstractGrowing high-yielding varieties is crucial for successful crop production and maximizing farmers’ net returns. One such example is IR05N221, locally referred to as Komboka rice variety, which was released in Kenya in 2013. On the one hand, Komboka can bridge the gap in rice imports since yields of existing rice varieties do not meet the increasing rice consumption levels of the Kenyan population. On the other hand, it has taken about seven years for Komboka to be appreciated by farmers, necessitating the need to understand farmer preferences when it comes to adopting a new improved variety. We used a mixed-method study approach by combining quantitative and qualitative data collected regionally and locally in both rainfed and irrigated ecologies. When compared to most of the other rice varieties under evaluation, Komboka was high-yielding, early-maturing, and had moderate tolerance to diseases in both rainfed and irrigated ecologies. However, farmers at the regional level ranked Komboka either at the same or lower rank in terms of sensory attributes. At the local level, farmers predominantly grew older and more aromatic Basmati 370 rice variety for sale, as it fetched them more money, with preferences for both men and women rice farmers being the same. Despite Komboka being a high-yielding variety, Mwea rice farmers’ perceptions and preferences for this improved variety were low. While Komboka was equally aromatic, the lack of a ready market dissuaded these farmers from widely preferring the new Komboka variety. We provide prerequisite information that can support the commercialization and promotion of the Komboka variety. We also show that widespread favourable perception of new varieties hinges on matching preferences between breeders’ efforts for improved rice productivity with farmers’ needs for market competitiveness in these new varieties.
Improving potassium use efficiency of sugarcane through the use of polyhalite
Authors: Herrera Wilfrand Ferney Bejarano , Arruda Bruna , de Carvalho Hudson Wallace Pereira , Pavinato Paulo Sergio 
Published: September 2022

Abstract
Background
Sugarcane (Saccharum officinarum) is an important crop in the production of food and energy in tropical and subtropical regions. To provide plants with what they need, highly concentrated fertilizers are often deployed which can result in imbalances in plant nutrition. The purpose of this study was to assess the efficiency of polyhalite (K2Ca2Mg(SO4)4·2H2O) as an alternative source of multinutrients for sugarcane compared to single sources of K, Ca, Mg and S.

Methods
A glasshouse experiment was carried out on a low-K Entisol from the sugarcane cultivar CV7870. A completely randomized design was used with different K fertilizer management strategies as follows: four K dosages (0, 21, 42 and 63 mg dm−3) associated to distinct sources, namely: polyhalite (PHY); potassium chloride (KCl); potassium chloride+polyhalite in a 1:1 ratio (½KP), and potassium chloride combined with phosphogypsum and kieserite balancing Ca, Mg and S dosages as supplied by pure polyhalite (KGK). Two growth cycles in 6 dm3 soil pots were evaluated: cane plant harvested at 131 days after transplanting, and ratoon harvested at 253 days after transplanting for the determination of dry matter production. Immediately before harvesting in both cycles, leaf nutrient content (K, Ca, S and Cl) was determined using a hand-held X-ray fluorescence spectrometer.

Results
In general, shoot dry matter and nutrient uptake were higher with the highest K dosage applied and K sources containing Ca and S in the formulation PHY; ½KP; and KGK, for both growth cycles. However, when these sources were provided at the lowest dosage, high agronomic efficiency was observed in all nutrients assessed. Consequently, the cultivar CV7870 was responsive to K application. However, increments in the K dosage resulted in low agronomic efficiency.

Conclusions
This study indicates that PHY is an effective fertilizer for sugarcane farmers seeking to improve nutrient uptake in a low-K Entisol for both cane plant and ratoon. A mix of PHY and KCl is a potential multi-nutrient fertilizer for managing sugarcane production.
Resilience of breadfruit agro-ecosystems in Hawaiʻi during the COVID-19 pandemic
Authors: Berning E. H. , Andersen C. V. H. , Mertz O. , Dickinson N. , Opgenorth M. , Lincoln N. K. , Rashford J. H. , Rønsted N. 
Published: September 2022

Abstract
Background
The COVID-19 pandemic is interrupting domestic and global food supply chains resulting in reduced access to healthy diverse diets. Hawaiʻi has been described as a model social-ecological system and it has been suggested that indigenous agro-ecosystems have the potential to be highly productive and resilient under changing land-use and climate change disturbance. However, little research has yet been conducted exploring the disruption and resilience of agro-ecosystems in Hawaiʻi caused by the COVID-19 pandemic. The breadfruit tree (Artocarpus altilis; Moraceae) is a signature, multi-purpose-tree of the complex perennial agro-ecosystems systems in Oceania.

Methods
This case study explores the ways in which the breadfruit agro-ecosystems of Hawaiʻi have shown resilience during the COVID-19 pandemic.

Results
Our study suggests that breadfruit has increased its value as a subsistence crop during the COVID-19 pandemic, even in a developed economy like Hawaiʻi, and that resilience of Hawaiian breadfruit agroe-cosystems during a crisis can be supported through cooperatives and food-hubs.
A linear approach to simulate a constant-Q model in time-domain ground-penetrating radar modeling using multiple Debye poles: Theory and application in karst carbonate rocks
Authors: Santos Bruno B. , Dantas Renato R. S. , Medeiros Walter E. , Lopes Juliana A. G. , Oliveira Jr. Josibel G. , Santana Flávio L. 
Published: September 2022

Dispersion is an important effect contributing to attenuating ground-penetrating radar (GPR) signals and must be incorporated in wave propagation. The constant-[Formula: see text] model (quality factor [Formula: see text]) is valid in rocks for typical GPR frequency ranges. In time-domain wave modeling, to simulate a constant-[Formula: see text] medium, using multiple Debye poles, the number of poles and their parameters must be previously estimated to honor target values for [Formula: see text] and velocity in the demanded frequency band. For electromagnetic waves, this problem is usually formulated as a highly nonlinear optimization problem presenting several solutions, which is solved using global optimization methods. An efficient linear approach to estimate multiple Debye poles to simulate constant-[Formula: see text] media for GPR data is presented. The resulting inverse problem is easy to solve because the number of poles is relatively small. The approach allows for a novel rescaled solution that depends only on the frequency band and number of poles. Solutions satisfying specific target values for velocity and [Formula: see text] are obtained from the rescaled solution by multiplying this solution by a proportionality factor that depends only on the target values. Choosing the number of poles is done so that velocity [Formula: see text] and [Formula: see text] curves, as a function of frequency [Formula: see text], are approximately invariant in the specified frequency band. Using the criterion that [Formula: see text] and [Formula: see text] curves must present maximum percentage deviations from the respective target values smaller than 5%, we find that, for the 200 MHz antenna, whose useful frequency band is 50–800 MHz, only three poles are sufficient. The theory is validated by modeling dispersion effects using synthetic models. The importance of introducing dispersion effects is illustrated by presenting a trial-and-error modeling approach to approximately reproduce a 200 MHz radargram acquired in fractured and karstified carbonate rocks.
Stochastic inversion of tracer test data with seismicity constraint for permeability imaging in enhanced geothermal reservoirs
Authors: Chen Jingyi , Xu Tianfu , Liang Xu , Jiang Zhenjiao 
Published: September 2022

Inference of permeability distribution in an enhanced geothermal reservoir is crucial for the sustainable management of geothermal energy. However, interpreting the uneven permeability distribution in a deep geothermal reservoir remains a challenging task because in practice there often are merely one or two wells available for hydrogeophysical tests. Considering that the induced seismicity data are widely captured during reservoir stimulation in enhanced geothermal systems, a framework of tracer test data inversion with the constraint of induced seismic data is developed for permeability imaging. Hydraulic diffusivity, representing the prior estimation of permeability, is inferred from the occurrence time of seismic events. This is followed by the determination of a petrophysical model, which relates hydraulic diffusivity to permeability, by tracer test data inversion based on the Markov chain Monte Carlo algorithm. Implementation of the seismicity-constraint tracer data inversion algorithm in the Habanero enhanced geothermal system, Australia, demonstrates that our inversion model allows uneven permeability estimation at field scale in shorter burn-in period and lower uncertainty than the traditional inversion model without seismicity constraint. Using the estimated permeability in the hydrothermal model enables accurate prediction of thermal performance in a 150 day trial-production test. Results indicate that this algorithm can reliably characterize the spatial distribution of permeability in deep enhanced reservoirs, based on the tracer test via doublet wells.