bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medication and Health Product Use Among Older Thais Adults : Behavioral Insights and Policy Recommendations: A Cross-Sectional Study
Authors: Srisak Tharinee , Ploylearmsang Chanuttha , Wongkongdech Adisorn , Chanthamath Souksathaphone , Wongkongdech Ranee 
Published: February 2025

Abstract

Background: Inappropriate medication and health product use (M&HP) among the elderly: impact health and health care costs. This study examined the behaviors and factors influencing medication and health product selection among elderly individuals in northeastern Thailand.
Methods:The Cross-sectional study was conducted among elderly participants residing in northeastern Thailand. Data were collected from 1,461 elderly individuals between March and November 2022. Personal characteristics and M&HP use behaviors were analyzed using descriptive statistics and factors influencing inappropriate M&HP use were analyzed using multiple logistic regression.
Results: 78.6% of participants had chronic diseases. When unwell, most sought care from clinics or hospitals. However, 84.46% used products without consulting professionals, and 52.9% relied on recommendations. Only 41.9% sought additional information about medications. Most behaviors were risky. Factors like unemployment and chronic diseases were associated with inappropriate medication use.
Conclusion: Thai elderly individuals, particularly those with chronic diseases and unemployed, are at risk of inappropriate medication and health product use due to easy access and lack of skills and assistance in accessing quality information. Our findings offer actionable insights for improving rational medication use and promoting health literacy among aging populations, aligning with global health priorities and those of Israel and similar aging societies.
Blood Flow Restriction Training Prior to and After Anterior Cruciate Ligament Reconstruction: A Scoping review
Authors: Claret Roger Fontanet , Roca Rafel Donat , Carballeira Eduardo 
Published: February 2025

Abstract

Background
Anterior cruciate ligament injuries often lead to muscle atrophy and prolonged recovery following anterior cruciate ligament reconstruction (ACLR). Blood flow restriction (BFR) has emerged as a strategy to optimize neuromuscular adaptations with lower loads, potentially enhancing rehabilitation outcomes in both preoperative and postoperative phases. This review aims to comprehensively evaluate the comparative effectiveness of BFR applied during resistance and endurance exercises versus non-BFR protocols, both before and after ACLR, while also examining key training parameters and BFR protocols to guide further research and clinical practice.
Literature search
A comprehensive literature search was conducted across multiple databases, including WoS, PEDro, Scopus, PUBMED (MEDLINE), SportDiscus, and the Cochrane Library, covering publications from inception to January 22, 2025. Studies eligible for inclusion were randomized controlled trials and quasi-randomized controlled trials that compared BFR interventions with non-BFR training in patients undergoing ACLR. Data synthesis followed the Preferred Reporting Items for Systematic Reviews and Meta-analysis extension for Scoping Reviews. The PEDro and CERT scales were used to assess the methodological quality of the included studies. Detailed training parameters and cuff specifications were extracted and summarized in tables.
Results
Fifteen of the initial 385 articles identified met the eligibility criteria and were included in the final analysis, comprising a sample of 417 patients. Outcomes were categorized into six areas: body composition, neuromuscular responses and adaptations, self-report questionnaires, functional measures, muscle physiology and biomarkers, and return to activity. Five articles focused on preoperative interventions, nine on postoperative interventions, and one addressed both phases.
Conclusion
This review suggests that BFR resistance training is an effective tool in the preoperative and postoperative phases of ACLR. Additionally, it can help improve muscle size, strength, functional measurements, body composition, muscle blood flow, and subjective perceptions.
From Tapinarof to Novel AhR Modulators: Computational Drug Discovery for Psoriasis Therapeutics
Authors: Santini Gianluca , Bonati Laura , Motta Stefano 
Published: February 2025

Abstract

The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor involved in the regulation of many patho-physiological processes. Among these, immune system modulation, as well as regulation of skin homeostasis and inflammation, make it a promising target for psoriasis therapy. Tapinarof, an AhR agonist recently approved for psoriasis treatment, exerts its action through antioxidant, anti-inflammatory and barrier-restoring effects. In this study, we employed a computational drug-discovery approach to identify novel AhR modulators with psoriasis therapeutic potential. We performed a multi-step similarity-based screening in PubChem. Application of molecular docking led to the identification of diverse chemical scaffolds with high docking scores and potential AhR activity, some of which belong to chemical classes with known pharmacological relevance. Notably, several identified compounds suggest a possible interplay between AhR signaling and sirtuin modulation, highlighting a previously unexplored avenue in psoriasis therapy. Our findings underscore the potential of computational approaches in accelerating the discovery of novel AhR-targeting agents and provide a foundation for further experimental validation.
Tracking of SARS-CoV-2 Variants of Concern by RT-PCR Assay in the Post-Pandemic Era
Authors: Shahid Saba , Parveen Sheeba , Vyas Naveen , Hani Hala , Annaduraia Sundhari , Asaadi Suhair , Kaabar Carlo 
Published: February 2025

aims:
This study aims to evaluate the performance of RT-PCR assays for COVID-19 detection and the use of a specific mutation RT-PCR-based approach to identify VOC in SARS-CoV-2 positive samples in post pandemic.

background:
The global impact of COVID-19 resulted in widespread illness and death. The rapid evolution of SARS-CoV-2, accompanied by increased transmission caused by Variants of Concern (VOC), became a significant concern in the post-pandemic.

objective:
This study has been conducted to evaluate the performance of multiplexed real-time reverse transcription-PCR (RT-PCR) assays for COVID-19 detection and the use of specific mutation RT-PCR-based approach to identify VOC in SARS-CoV-2 positive samples in the northern part of the UAE.

method:
We selected 200 respiratory specimens tested between October 2022 to January 2023, at the Pure Lab Al Qassimi Women and children hospital, Sharjah, UAE. We evaluated the performance of four commercially available RT-PCR kits for COVID-19 detection. Further, the positive samples were used to identify variants by variant detection kit as required for mutations in Spike protein (HV 69-70 DEL, N501Y, E484K, K417N) to identify Omicron, British and SARS-CoV-2 wild type (WT) E Gene variants respectively.

result:
In the post-pandemic period, 153/200 (76.5%) positivity was observed. There was a higher prevalence of COVID-19 among males, accounting for 52% of the cases, in comparison to females 48% aged between 20-40 years. Variant analysis showed that 50 samples were detected for the SARS-CoV-2 OMICRON variant (B.1.1.529), 4 samples were detected for the SARS-CoV-2 British variant (B.1.1.7), however, 99 samples were detected for SARS-CoV-2 wild type (WT) E Gene with no mutation.

conclusion:
This study demonstrates the efficacy of a rapid and cost-effective RT-PCR assay designed to detect spike mutations to effectively contribute to public health response efforts. Additionally, by performance evaluation of PCR kits for COVID-19 detection with the Cycle Threshold (CT) values obtained from diagnostic PCR, we can gather valuable insights into the viral load of samples. This information helps us gauge the extent of transmission and assess the severity of the disease within the population.

other:
NA
Study on the Anti-Fatigue Effects of Polysaccharides from Erjing Formula
Authors: Lin Zicheng , Yang Mingshuo , Liu Jinsui , Yang Can , Liang Lixuan , Pan Jiaqi , Yang Quan , Pan Liming 
Published: February 2025

Background:
The traditional Chinese recipe "Erjing Formula", composed of
HuangJing and GouQi, is recognized for its tonifying and revitalizing properties, but the active
components responsible for these effects are poorly explored. This study investigated the antifatigue
effects of Erjing Formula polysaccharides (EJFP).

Methods:
Mice were treated with EJFP and subjected to weight-loaded swimming tests. Biochemicals
were measured, while muscle changes were analyzed by H&E staining and protein
expression by Western blotting.

Objective:
The present study aimed to investigate the anti-fatigue effects of EJFP through
weight-loaded swimming tests in mice.

Methods:
SPF-grade healthy male rat species KM mice were gavaged with EJFP and then subjected
to a weight-loaded swimming test. Later, the levels of various biochemical indicators,
including blood lactate (BLA), blood urea nitrogen (BUN), superoxide dismutase (SOD),
malondialdehyde (MDA), muscle glycogen (MG), and hepatic glycogen (HG), were measured.
The muscle tissue slices were analyzed using hematoxylin and eosin H&E) staining. Additionally,
the expression levels of Kelch-like ECH-associated Protein 1 (Keap-1) and nuclear factor
erythroid 2-related factor 2 (Nrf2) in the muscle tissue of each group were detected using Western
Blotting.

Results:
EJFP (Erjing Formula Polysaccharides) significantly increased swimming time (p ≤
0.01), reduced oxidative stress markers and detrimental metabolites (BLA, BUN, and MDA),
and elevated SOD, MG, and HG levels. Histologically, it improved muscle integrity. Nrf2 expression
increased, indicating a relationship between antioxidant effects and antifatigue activity.

Conclusion:
EJFP demonstrated anti-fatigue effects, mainly at moderate doses, by modulating
the Nrf2/Keap1 pathway and improving glycogen and antioxidant levels. This is the first study to
document the anti-fatigue effects of Erjing Formula polysaccharides, establishing a theoretical
basis for practical applications in the development of anti-fatigue products.
Chemical Constituents in the Seeds of Premna odorata
Authors: Nguyen Hoang Sa , Duong Thi Thanh Truc , Nguyen Thi Kieu Trinh , Huynh Thi Hong Trang , Dao Duc Thien 
Published: February 2025

Abstract:
Premna odorata is a plant species with various medicinal properties. However, in Central
Vietnam, the seeds of this plant have not been previously studied for their chemical constituents. The
aim of this study was to isolate and identify compounds from the seeds of P. odorata collected from
Phu Yen province, Vietnam. The seeds were extracted using dichloromethane. The chemical constituents
were isolated and purified. Their structures were elucidated through spectroscopic methods,
including one-dimensional (1D) and two-dimensional (2D) Nuclear Magnetic Resonance (NMR)
spectroscopy, mass spectrometry, and comparison with existing literature data. A new triterpenoid (1)
and four known flavonoids: diosmetin (2), luteolin (3), acacetin (4), and apigenin (5), were successfully
isolated from the dichloromethane extract of P. odorata seeds. The structures of these compounds
were determined based on spectroscopic data. Compound 1 was also tested for cytotoxicity on
the KB cell line, showing significant activity with an IC50 value of 40.98 μM. This study presents the
first chemical investigation of the seeds of P. odorata. The identification of one new triterpenoid and
four known flavonoids contributes to the understanding of the chemical composition of this plant and
provides a basis for further pharmacological studies.
Revealing the Antidiabetic Potential of Herbal Nanoparticles
Authors: Datta Kunal , Bhattacharyya Soubhik , Narzary Christina , Mukherjee Reshmi , Naskar Angana , Imam Shazma , Chakraborty Subarno , Sarkar Dhrubajyoti 
Published: February 2025

Abstract:
Diabetes is a chronic metabolic disorder that is characterized by high postprandial blood
sugar levels and increased fasting, which disrupts physiological balance and causes organ damage.
Owing to the global health risk of type 2 diabetes, natural remedies have shown promise as viable
alternatives because of their outstanding antidiabetic properties. Nevertheless, the therapeutic use of
these compounds is rather restricted due to their inadequate solubility, instability in the gastrointestinal
tract, low absorption, and other related factors. Currently, the development of nanoscale systems
is a notable approach to enhancing the delivery of phytochemicals. This study aims to investigate
the advancements in drug delivery techniques using nanoparticles, with a particular focus on
enhancing the effectiveness of herbal remedies in the treatment of diabetes. This study aims to enrich
our understanding of nanotechnology's potential in enlightening drug delivery systems by employing
database repositories like PubMed, Scopus, Google Scholar, and Web of Science. Based on
their categorization and structure, nano-systems are classified into liposomes, nanostructured lipid
carriers, phytosomes, niosomes, solid lipid nanoparticles, self-nano emulsifying drug delivery systems,
and inorganic nano-carriers. This study intricately describes the formulation process, selection
criteria, and mechanism of herb-loaded nanoparticles using an example of the pharmacokinetic and
pharmacodynamic properties of antidiabetic herbal drugs. Researchers have proven that nanoformulations
of herb-loaded antidiabetic drugs improve compliance and therapeutic efficacy by resolving
pharmacokinetic and biopharmaceutical issues. We could expect the creation of nanoformulations
to be a viable method for optimizing the therapeutic effectiveness of plant-produced
antidiabetic compounds.
Perkawinan Usia Anak Perspektif Hak Asasi Manusia
Authors: Hamzah Ahmad Zakiy Mubarak 
Published: February 2025

Artikel ini akan mencoba melihat tentang perkawinan Usia Anak Perspektif Hak Asasi Manusia. Tema perkawinan Usia anak, menjadi isu yang sering diperbincangkan oleh para ilmuwan dan masyarakat, baik local maupun nasional dan menjadi isu kontemporer, karena dalam ketentuan undang-undang bahwa batasan usia perkawinan itu adalah 19 tahun. Tetapi kerap terjadi pelanggaran hukum terhadap ketentuan usia tersebut disebabkan karena banyak factor, misalnya factor budaya yang menganggap pamali jika terlambat kawin padahal sudah ada yang melamar, factor ekonomi/kemiskinan dan factor hamil di luar nikah serta Pendidikan rendah. Terlepas dari factor-faktor tersebut perkawinan usia anak dipandang melanggar hak asasi manusia, terutama hak anak yang seharusnya masih bisa menikmati masa bermain, dan hak untuk mendapatkan Pendidikan.
Financial Technology Sebagai Solusi Potensial Market Yolo Style Gen Z Kota Makassar
Authors: Tajrim Muh. , Awalauddin Murtiadi , Haddade Abdul Wahid 
Published: February 2025

Penelitian ini bertujuan untuk mengetahui pola spending YOLO (You Only Live Once) style yang dijalani oleh Gen Z (Generasi Z) di kota Makassar lalu mengaitkannya dengan peran fintech sebagai solusi YOLO style Gen Z kota Makassar sebagai potensial market. Metode penelitian yang digunakan dalam penelitian ini adalah penelitian kualitatif dengan pendekatan fenomenologi. Adapun sumber data yang diperoleh dari data primer yang bersumber dari 9 responden Gen Z yang lahir dari rentang tahun 1995 sampai dengan tahun 2012. Hasil dari penelitian ini menemukan bahwa pola spending Gen Z YOLO style kota Makassar terbagi menjadi tiga tema, yakni pola spending terkait konsumsi terhadap experience, pola spending terkait present time, dan pola spending terkait prinsip dalam mengkonsumsi. Financial technology, baik konvensional terlebih lagi syariah, sangat cocok untuk diaplikasikan pada Gen Z YOLO style kota Makassar karena mampu memberikan solusi terhadap segala permasalah yang ditemukan pada tiga tema poloa spending tersebut.
PEMBINAAN PERILAKU MODERASI BERAGAMA GURU PAI DAN KEPALA SEKOLAH SMA NEGERI 1 PASAR WAJO KABUPATEN BUTON
Authors: Andera La Kaisar , Usman Syahruddin , Muhammad Yahdi  
Published: February 2025

Penelitian ini bertujuan untuk mendeskrpisikan pembinaan perilaku moderasi beragama yang dilakukan oleh Guru PAI dan Kepala Sekolah SMA Negeri 1 Pasarwajo Kabupaten Buton. Jenis penelitian yang digunakan adalah (field research) atau penelitian lapangan dengan menggunakan metode penelitian kualitatif deskripitif. Pendekatan dalam penelitian ini yaitu fenomenologis, sosiologis, pedagogis. Sumber data terdapat dua yaitu primer dan sekunder. Adapun metode pengambilan data yang digunakan yaitu, observasi, wawancara, dan dokumentasi. Instrument yang digunakan yaitu pedoman observasi, pedoman wawancara, dan dokumentasi. Lalu teknik pengolahan dan analisis data dilakukan melalui tiga tahapan, yakni reduksi data, penyajian data, pengujian keabsahan data dan pengambilan kesimpulan serta verifikasi. Hasil penelitian ini menunjukkan bahwa perilaku moderasi beragama peserta didik di SMA Negeri 1 Pasarwajo Kabupaten Buton secara umum sangat baik dan telah memenuhi indikator moderasi beragama, hal ini dilihat dari: sikap toleransi peserta didik (saling menghargai dan menghormati perbedaan), sikap komitmen kebangsaan (cinta kepada tanah air), akomodatif budaya lokal (peserta didik aktif mengikuti kegiatan-kegiatan kebudayaan baik lokal maupun nasional), sikap anti kekerasan, (peserta didik tidak terlibat dalam pertikaian antara muslim dan non muslim, non muslim merasa aman dan nyaman bersekolah di SMA Negeri 1 Pasarwajo). Adapun strastrategi kepala sekolah dan guru PAI dalam membina perilaku moderasi beragama peserta didik SMA Negeri 1 Pasarwajo Kabupaten Buton, yaitu: kolaborasi (antar kepala sekolah, guru PAI dan guru mata pelajaran lain), integrasi nilai-nilai moderasi beragama (penyisipan nilai-nilai moderasi dalam pembelajaran PAI dan pelajaran lain), kegiatan ekstrakurikuler (menyelenggarakan kegiatan tentang moderasi beragama), penerapan metode dalam pembelajaran (metode ceramah, diskusi kelompok, tanya jawab, simulasi peran, dan memberi teladan tentang sikap yang moderat dalam beragama). Implikasi dari penelitian ialah penelitian ini dapat memberi dukungan sekaligus masukkan kepada kepala sekolah dan Guru PAI SMA Negeri 1 Pasarwajo untuk meningkatkan kolaborasi dan strategi serta metode dalam mebina perilaku moderasi beragama.
STRATEGI GURU MENGAJI DALAM MENINGKATKAN KEMAMPUAN MEMBACA AL-QUR’AN SANTRI TPA NURUL TAKWA DI DESA BONTOKADATTO KECAMATAN POLONGBANGKENG SELATAN KABUPATEN TAKALAR
Authors: Ayu Surahman  , La Ode Ismail Ahmad  , Syamsul Qamar  
Published: February 2025

Artikel ini bertujuan untuk mendeskripsikan strategi yang digunakan guru mengaji dalam meningkatkan kemampuan membaca al-Qur’an santri. 1) Untuk mendeskripsikan strategi guru mengaji dalam meningkatkan kemampuan membaca al-Qur‘an santri di TPA Nurul Takwa. 2) Untuk mendeskripsikan kualitas kemampuan membaca al-Qur‘an santri di TPA Nurul Takwa, Desa Bontokadatto. 3) Untuk mendeskripsikan faktor pendukung dan faktor penghambat guru mengaji dalam meningkatkan kemampuan membaca al-Qur‘an santri di TPA Nurul Takwa. 4) Untuk mendeskripsikan solusi guru dalam mengatasi hambatan dalam mengajar mengaji di TPA Nurul Takwa. Hasil penelitian yang diperoleh ialah, 1) strategi guru mengaji dalam meningkatkan kemampuan membaca al-Qur’an santri yaitu, a] guru menggunakan strategi peer tutor, b] guru menggunakan pembelajaran yang interaktif, c] guru menggunakan berbagai metode yang cocok untuk digunakan. 2) Untuk kemampuan membaca al-Qur’an santri di TPA Nurul Takwa bisa dikategorikan baik, akan tetapi masih ada beberapa santri yang masih kurang baik dalam melafalkan huruf-huruf hijaiyah yang dimana santri ini baru masuk di TPA Nurul Takwa. 3)Faktor pendukung dalam meningkatkan kemampuan membaca al-Qur’an santri, yaitu kualitas guru yang cukup baik, dan orang tua santri yang mendukung anaknya belajar mengaji di TPA. Sedangkan faktor yang menghambatnya yaitu: a) Lingkungan belajar yang kurang memadai, b) Kurangnya minat santri untuk belajar mengaji, c) Pemahaman santri saat belajar mengaji.
Development of Skills Valuable for Military Service Through Diving from the Perspective of a Civilian Instructor
Authors: Jordan Józef , Parczewski Rafał 
Published: February 2025

Abstract
This article examines skills that may be beneficial from the viewpoint of a diving instructor in military service. Diving is an extreme sport popular in both civilian and military environments. Skills acquired through diving courses can be useful for service in the Polish Armed Forces, but also in various other uniformed formations. In the collected research material, the authors of the article mainly relied on the opinions of selected civilian instructors and on their own professional experience. The article presents the tasks and structure of the Training Center for Divers and Scuba Divers of the Polish Army, on the basis of the available literature. The main purpose of the article is to present the usefulness of the sport for candidates, as well as soldiers themselves in the Armed Forces. The first part of the paper will present the basic concepts related to diving, while the second part will describe the results of the research with conclusions and recommendations .
Selected Psychological Aspects of Recruiting Candidates for Diving and Scuba Diving
Authors: Wolański Władysław , Pełka Stanisław , Ramisch Józef 
Published: February 2025

Abstract
This paper presents the results of a pilot programme to include psychological tests in the recruitment rules for candidates for military divers and scuba divers. A total of 207 candidates to undertake training at the Polish Army Divers and Scuba Divers Training Centre were examined. They were subjected to tests of mental fitness, tests examining personality traits, tests of psychomotor fitness and tests of general fitness.
Numerous psychological contraindications to undertake diving training and service were found; the most common was a low degree of mental fitness.
In conclusion, it was suggested that, following the example of other countries, psychological testing should be included in the selection of candidates for divers.
The results of the tests, although not obligatory, were partly taken into account in the opinion issued by the Military Medical and Maritime Commission.