bluuebunny/crossref_metadata_2025_split huggingface dataset:
The blue light receptor CRY1 interacts with FIP37 to promote N6‐methyladenosine RNA modification and photomorphogenesis in Arabidopsis
Authors: Yang Jiaxin , Li Lan , Li Xin , Zhong Ming , Li Xinmei , Qu Lina , Zhang Hui , Tang Dongying , Liu Xuanming , He Chongsheng , Zhao Xiaoying 
Published: October 2022

Summary

Light is a particularly important environmental cue that regulates a variety of diverse plant developmental processes, such as photomorphogenesis. Blue light promotes photomorphogenesis mainly through the activation of the photoreceptor cryptochrome 1 (CRY1). However, the mechanism underlying the CRY1‐mediated regulation of growth is not fully understood.

Here, we found that blue light induced N6‐methyladenosine (m6A) RNA modification during photomorphogenesis partially via CRY1. Cryptochrome 1 mediates blue light‐induced expression of FKBP12‐interacting protein 37 (FIP37), which is a component of m6A writer. Moreover, we showed that CRY1 physically interacted with FIP37 in vitro and in vivo, and mediated blue light activation of FIP37 binding to RNA. Furthermore, CRY1 and FIP37 modulated m6A on photomorphogenesis‐related genes PIF3, PIF4, and PIF5, thereby accelerating the decay of their transcripts.

Genetically, FIP37 repressed hypocotyl elongation under blue light, and fip37 mutation could partially rescue the short‐hypocotyl phenotype of CRY1‐overexpressing plants.

Together, our results provide a new insight into CRY1 signal in modulating m6A methylation and stability of PIFs, and establish an essential molecular link between m6A modification and determination of photomorphogenesis in plants.
Clinical Effect of Minimally Invasive Microendoscopic‐Assisted Transforaminal Lumbar Interbody Fusion for Single‐Level Lumbar Disc Herniation
Authors: Chen Gang , Li Long Biao , Shangguan Zhitao , Wang Zhenyu , Liu Wenge , Li Jiandong 
Published: October 2022

ObjectiveThis retrospective study aimed to compare the clinical and radiological outcomes of transforaminal lumbar interbody fusion (TLIF) through the Wiltse approach (W‐TLIF) vs minimally invasive microendoscopy‐assisted transforaminal lumbar interbody fusion (ME‐TLIF) in single‐segment lumbar disc herniation (LDH).MethodsA retrospective study was conducted to study the differences in specific clinical outcomes between single‐segment LDH patients receiving W‐TLIF and ME‐TLIF. Single‐segment LDH patients admitted to the Fujian Medical University Union Hospital from March 2015 to June 2018 were included.All the participants were divided into the ME‐TLIF group or the W‐TLIF group according to their TLIF surgery types. Demographic characteristics, the visual analog score (VAS), Oswestry Disability Index (ODI), Japanese Orthopaedic Association (JOA) scale, blood loss volume, postoperative drainage, ambulated time, initial postoperative back pain, hospitalization duration, expenses, and improvement rates of patients in the two groups were collected for analysis. Radiographic fusion was ultimately assessed via the Bridwell interbody fusion grading system. All selected patients with TLIF were followed up for 1 year.ResultsFifty‐seven patients were selected, with 26 in the ME‐TLIF group and 31 in the W‐TLIF group, both of whom were followed up for 1 year. The mean age of the included patients was 53.75 ± 9.313 years, and the sex ratio was indiscrimination. There was no significant difference in demographic data or operating time between the two groups prior to surgery. The blood loss volume (ME‐TLIF: 228.5 vs W‐TLIF: 681.3), postoperative drainage (ME‐TLIF:82.1 ± 23.5 vs W‐TLIF: 345.8 ± 65.2), initial postoperative back pain (ME‐TLIF: VAS_3 days: 1.96 ± 0.60 VAS_7 days: 1.73 ± 0.53, W‐TLIF: VAS_3 days: 2.48 ± 0.51 VAS_7 days: 1.87 ± 0.43), and hospitalization duration (ME‐TLIF: 9.04 vs. W‐TLIF: 11.29) were all significantly lower in the ME‐TILF group (p < 0.05). However, there were no statistical differences between the two groups in VAS, ODI, and JOA at 1 month, 3 months, 6 months, and 1 year postoperatively (p > 0.05). The fusion rates of the two groups showed no notable difference (p > 0.05), while the X‐ray exposure time in the ME‐TLIF group was significantly longer than in the W‐TLIF group (p < 0.05).ConclusionsME‐TLIF surgery was an effective and satisfactory surgical technique to manage LDH. Although ME‐TLIF increased the operation time and intraoperative fluoroscopic irradiation volume, it could effectively relieve low back pain from early postoperative onset and promote early postoperative recovery compared with W‐TLIF.
Tracing plant source water dynamics during drought by continuous transpiration measurements: An in‐situ stable isotope approach
Authors: Kübert Angelika , Dubbert Maren , Bamberger Ines , Kühnhammer Kathrin , Beyer Matthias , van Haren Joost , Bailey Kinzie , Hu Jia , Meredith Laura K. , Nemiah Ladd S. , Werner Christiane 
Published: October 2022

AbstractThe isotopic composition of xylem water (δX) is of considerable interest for plant source water studies. In‐situ monitored isotopic composition of transpired water (δT) could provide a nondestructive proxy for δX‐values. Using flow‐through leaf chambers, we monitored 2‐hourly δT‐dynamics in two tropical plant species, one canopy‐forming tree and one understory herbaceous species. In an enclosed rainforest (Biosphere 2), we observed δT‐dynamics in response to an experimental severe drought, followed by a 2H deep‐water pulse applied belowground before starting regular rain. We also sampled branches to obtain δX‐values from cryogenic vacuum extraction (CVE). Daily flux‐weighted δ18OT‐values were a good proxy for δ18OX‐values under well‐watered and drought conditions that matched the rainforest's water source. Transpiration‐derived δ18OX‐values were mostly lower than CVE‐derived values. Transpiration‐derived δ2HX‐values were relatively high compared to source water and consistently higher than CVE‐derived values during drought. Tracing the 2H deep‐water pulse in real‐time showed distinct water uptake and transport responses: a fast and strong contribution of deep water to canopy tree transpiration contrasting with a slow and limited contribution to understory species transpiration. Thus, the in‐situ transpiration method is a promising tool to capture rapid dynamics in plant water uptake and use by both woody and nonwoody species.
Defining social equity in emergency management: A critical first step in the nexus
Authors: Rivera Jason D. , Knox Claire Connolly 
Published: October 2022

AbstractThe conceptualization of social equity in public administration and emergency management has been subjective to the user of the term. While the vagueness of the concept provides fertile grounds for intellectual debate, the failure to arrive at a single and formal definition leads to confusion and an inability to measure it as a programmatic or policy goal. For emergency management, how scholars define social equity within research is profoundly important for assessing and making recommendations related to governmental practices that have social equity as its guiding principle. To address this detrimental definitional situation, this research analyzes 15 years of social equity related peer‐reviewed articles in highly ranked emergency management journals. This manuscript concludes with a proposed working definition of social equity, recommendations to measure the concept, and a discussion of its implications for future research and practice.
Mainstreaming displacement in development policies: An analysis of Solomon Islands and Vanuatu approaches
Authors: Endacott Joanna , Alam Shawkat 
Published: October 2022

AbstractPacific Small Island Developing States are uniquely vulnerable to climate disasters due to their geography and capacity to address disaster, displacement and development challenges. Climate disasters often trigger internal displacement. Long‐term recovery responses are ad hoc and unsustainable, often resulting in protracted displacement that undermines development progress. As displacement poses cross‐sectoral challenges, a development policy approach encourages integrated, durable solutions for internally displaced persons and host communities. This article advocates for mainstreaming displacement into development policy rather than treating it as a distinct policy issue. The article outlines the role of international law in guiding national displacement practices and analyse the policy experiences of Vanuatu and the Solomon Islands. Vanuatu has experienced widespread disaster displacement events, and the Solomon Islands have seen communities permanently relocate due to climate change. The article examines governance and institutional barriers inhibiting effective policy design and implementation. It concludes that mainstreaming displacement into development policies will promote integrated, inclusive and sustainable solutions for protracted displacement.
Beyond a centre‐periphery approach: Inter‐minority tensions and the development of contested categories of Kurdish mobilization in Iran
Authors: Khalili Mostafa 
Published: October 2022

AbstractA significant feature of Kurdish history over the last several decades has been the proclivity of the Kurds for ethnic mobilization. The socio‐political incentives that lead to the mobilization of different Kurdish sub‐groups are usually complex and occasionally serve ambiguous political aspirations. To unpack such complexities, as the title of this paper suggests, it is useful to add an additional analytical lens to the common centre‐periphery approach (i.e. state nationalism vs. Kurdish resistance) by focusing on the mobilization incentives within the local context. To do so, the paper presents an ethnographic study of the social processes that shape the dynamics of Kurdish mobilization in the multi‐ethnic city of Urmia in northwestern Iran, where Kurmanji‐speaking Kurds live together with Azerbaijani Turks and in close proximity to Sorani‐speaking Iranian Kurds. The paper argues that the mobilization incentives for the Kurmanji‐speaking Kurds in the local context of Urmia often serve contradictory political ends, ranging from denial of the Kurdish nation at the inter‐ethnic layer to dividing it at the intra‐ethnic layer, and romanticizing it at the transnational layer. The broader contribution of this paper is to elucidate how these different and sometimes contradictory forms of ethnic mobilization are able to coexist, given that they are all characterized by the same emancipatory force – ‘a politico‐symbolic struggle over power and prestige’, in Bourdieu's terminology.
Phenotypic profiling of CD279 and CD185 level on helper T cells in patients with autoimmune hepatitis
Authors: Hou Yiwen , Liu Ying , Chen Chen , Li Zhurong , Li Zhencheng , Liu Yang , Hao Huiqin , Hou Tiezheng 
Published: October 2022

AbstractThe break of immune tolerance and transition from acute to chronic information in the liver lead to the development and persistence of autoimmune hepatitis. Elevated CD279 expression has been detected in type 1 autoimmune hepatitis (AIH) patients with anti‐nuclear and/or anti‐smooth muscle antibodies. This is correlated with increased CD185 positive CD4+ helper T cells which activate B cells producing autoantibodies. However, detailed CD279 profiles on T cell subsets were not clear. Here, we analysed PBMCs of 53 AIH patients and 18 healthy donors. Our work revealed that for their central and effector memory compartment of CD4 T cells was markedly increased. Furthermore, the percentage of CD279+CD185+ and CD279−CD185+ T follicular helper cells as well as CD279+CD185− but not CD279−CD185− populations are significantly enlarged in naïve, central and effector memory subsets. This study suggests that high levels of CD279 and CD185 expression are strongly associated with AIH and may inform disease progression and provide a potential novel therapeutic target.
Effects of Hole Blockage on Endwall Film Cooling and Vane Phantom Cooling Performances of a Transonic Turbine Vane
Authors: Bai Bo , Li Zhigang , Zhang Kaiyuan , Li Jun , Mao Shuo , Ng Wing F. 
Published: October 2022

Abstract
Although the thermal-barrier coating (TBC) can protect the gas turbine components from the hot mainstream gas, it is not uncommon that the TBC partially blocks the film cooling holes during the spraying process. The film cooling hole blockage will alter the coolant flow behaviors and lead to a significant variation in film cooling performance. In this paper, a physical model of blockage holes including two key parameters of blockage ratios (B) and blockage angles (α), was proposed to analyze the effects of hole blockage on endwall film cooling performance, phantom cooling performance of vane pressure side surface (PS), and overall cooling performance. Based on a proposed double-coolant-temperature prediction method, the endwall film cooling effectiveness, phantom cooling effectiveness of the vane PS and area-averaged cooling effectiveness of an actual vane passage were numerically calculated and analyzed, for the common holes and blockage holes (three different blockage ratios of B and three different blockage angles of α) at the similarly realistic operating conditions of a gas turbine. Results indicated the hole blockage is pernicious to endwall film cooling performance, leading to a significant decrement of endwall film cooling effectiveness (up to 30% at B = 0.4), where the decrement magnitudes increase with increasing the blockage ratios (B). Compared to the blockage ratios (B), the effects of blockage angle (α) on endwall film cooling effectiveness are secondary and slight (less than 10% in η). Nonetheless, the hole blockage is beneficial to phantom cooling performance of the vane PS, leading to an obvious enhancement (more than 40%) in area-averaged phantom cooling effectiveness with increasing blockage ratios (B), due to the increase of the local blowing ratio (BReff). The area-averaged cooling effectiveness including endwall film cooling and phantom cooling on PS, decreases with the increase of blockage angle (α), and the benefits of hole blockage in overall cooling performance are negative at α = 20 deg. This suggests that the overlarge blockage ratios and short blockage lengths (correspond to the blockage position near film cooling holes exit or large blockage angle of α), should be utmost avoided during the spraying process of the TBC, otherwise, the film cooling scheme designs, based on the geometry of the pristine holes, may be inefficient.
Biaxial Tensile Prestress and Waveguide Effects on Estimates of the Complex Shear Modulus Using Optical-Based Dynamic Elastography in Plate-Like Soft Tissue Phantoms
Authors: Dore Marta , Luna Aime , Royston Thomas J. 
Published: October 2022

AbstractDynamic elastography attempts to reconstruct quantitative maps of the viscoelastic properties of biological tissue, properties altered by disease and injury, by noninvasively measuring mechanical wave motion in the tissue. Most reconstruction strategies that have been developed neglect boundary conditions, including quasi-static tensile or compressive loading resulting in a nonzero prestress. Significant prestress is inherent to the functional role of some biological tissues, such as skeletal and cardiac muscle, arterial walls, and the cornea. In the present article a novel configuration, inspired by corneal elastography but generalizable to other applications, is studied. A polymer phantom layer is statically elongated via an in-plane biaxial normal stress while the phantom's response to transverse vibratory excitation is measured. We examine the interplay between biaxial prestress and waveguide effects in this plate-like tissue phantom. Finite static deformations caused by prestressing coupled with waveguide effects lead to results that are predicted by a novel coordinate transformation approach previously used to simplify reconstruction of anisotropic properties. Here, the approach estimates material viscoelastic properties independent of the nonzero prestress conditions without requiring advanced knowledge of those stress conditions.
Molecular Mechanisms Underlying the Effect of Paeoniae Radix Rubra on Sepsis-Induced Coagulopathy: A Network Pharmacology and Molecular Docking Approach
Authors: Gao Shan , Wang Dongsheng 
Published: October 2022

Abstract
To investigate the effective components and underlying mechanism of Paeoniae radix rubra (PRR) in treating sepsis-induced coagulopathy (SIC) on the basis of network pharmacology and molecular docking approaches. At present, no therapeutic agent has been approved for the treatment of SIC. Identifying drugs for SIC from Chinese medicine is an encouraging research direction. The predicted targets and effective components of PRR were identified by analysis of the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. Bio-informatics databases were employed to identify the disease targets of SIC. These key targets were then uploaded to the STRING database to generate protein–protein interaction networks. The ORG package in rv4.1.2 software was applied for functional and pathway enrichment analyses of the key targets. Finally, discovery studio software was used to perform docking analyses of key targets and effective components. Nine chemically active components and 84 common targets associated with drugs and SIC were identified. Protein–protein interaction (PPI) network analysis identified several key targets. Further analysis identified enrichment in several signaling pathways; these changes could exert influence on a number of biological processes, including responses to xenobiotic stimuli, oxidative stress, molecules of bacterial origin, thus playing an anti-SIC pharmacological role. According to molecular docking results, these key targets had strong binding affinity to the active components. PRR can contribute to SIC by medicating core target genes (e.g., CASP3, PTGS2, TP53, AKT1, MMP9, TNF, JUN, IL6, and CXCL8), and regulating multiple key pathways (e.g., the lipid and atherosclerosis pathway).
Adaptive Learning and Optimization of High-Speed Sailing Maneuvers for America's Cup
Authors: Rodriguez Renato , Wang Yan , Ozanne Joseph , Morrow Jay , Sumer Dogan , Filev Dimitar , Soudbakhsh Damoon 
Published: October 2022

AbstractThis paper presents an adaptive control strategy to optimize the sailing maneuvers of an AC75 foiling sailboat competing in America's Cup. Foiling yachts have nonlinear, high-dimensional, and unstable dynamics due to several articulations for fast motions and maneuverability. Achieving aggressive and optimal maneuvers requires taking these complex dynamics into account instead of analytical optimizations using reduced-order models. We compared extremum-seeking and Jacobian learning (JL) control approaches on a full-order model to achieve optimal maneuvers and used JL to optimize articulations. The controllers were integrated with a high-fidelity sailboat simulator for safe and efficient maneuver optimization. The optimal solutions were subject to physical/actuator constraints and those enforced to ensure the feasibility of the maneuvers by humans (sailors). The close-hauled and tacking maneuvers were optimized to achieve maximum velocity made good (VMG) and minimum loss of VMG, respectively. The optimal maneuvers boast a marginal VMG loss of less than 1.5%, which enables exploiting areas of good wind conditions in the racing environment.
Effective Constitutive Relations for Sintered Nano Copper Joints
Authors: Thekkut Sanoop , Sivasubramony Rajesh Sharma , Raj Arun , Kawana Yuki , Assiedu Jones , Mirpuri Kabir , Shahane Ninad , Thompson Patrick , Borgesen Peter 
Published: October 2022

Abstract
Sintered copper nanoparticles are being considered as alternatives to solder and/or sintered silver in different applications. Like for the alternatives, the interpretation of accelerated fatigue test results does however require modeling, typically involving prediction of stresses and strains versus time and temperature based on constitutive relations. This poses a challenge as the inelastic deformation properties depend strongly on both the initial particles and details of the processing, i.e., unlike for solder general constitutive relations are not possible. This work provides a mechanistic description of the early transient creep of relevance in cycling, including effects of sintering parameters and subsequent oxidation. Inelastic deformation is dominated by diffusion, rather than dislocation motion. Generalized constitutive relations are provided to the extent that quantitative modeling of a specific structure only requires the measurement of a single creep curve for that.
A New Molecular Insight in Effects of Alcohol Co-Solvents on Miscibility of Anhydrous Ethanol/Diesel Blends
Authors: Li Xueying , Hou Lei , Chai Chong , He Sichen , Huang Yanan 
Published: October 2022

Abstract
Sustainable policy leads to partially replace fossil diesel by bio-fuels and ethanol/diesel blends. The major challenge is how to enhance miscibility of ethanol with diesel. Molecular dynamics simulation was applied to study the effects of alcohol co-solvents on miscibility of ethanol with diesel. The 1-heptanol, 1-decanol, n-butanol, and butanol isomers were selected as co-solvents. The diesel model was constructed to quantitatively characterize miscibility and obtain interaction of ethanol and diesel. The solubility parameters, structural feature, and energy properties were analyzed. The results showed that long-chain alcohol co-solvents contributed to miscibility of blends. The aromatics had more effects on miscibility than linear alkanes and cycloalkanes. Radial distribution function results showed that straight-chain alcohols or high linearity co-solvents promoted miscibility of ethanol than branched alcohols. The energy analysis revealed that the hydrogen bonding and van der Waals interaction were the main driving forces to improve miscibility, while polarization interaction had no major contribution. The hydrogen bonding dominated for short-chain alcohols, while van der Waals interaction was vital for long-chain alcohols. The coordination of hydrogen bonding and van der Waals energy in dynamic equilibrium led to the optimal miscibility.
Modeling and Simulation of the Cavitation Phenomenon in a Turbopump: A Multiphase Approach
Authors: Cazé Joris , Petitpas Fabien , Daniel Eric , Le Martelot Sébastien , Queguineur Matthieu 
Published: October 2022

Abstract
In this study, cryogenic flows in rocket engine that may undergo a phase change because of a loss of pressure in pump, or any depressurization process are considered. We proposed a well-posed mathematical representation for this kind of flow as well as the numerical model for seeking the solutions. The two important points addressed in this study are: the compressibility of the phases and the use of a rotating reference frame. The compressibility effects are quite essentials to obtain a physical and realistic cavitation model through the equation of state of the fluids (liquid and vapor), while the moving reference frame being the way we chose to model the pump motion.
The model we develop is based on conservation equations of mass, momentum and energy for each phase plus a non-conservative equation evolution for the volume fraction. The description of the flow is based on the diffuse interface method: the interfaces appear naturally in the flow (interfaces between vapor and liquid for example) and do not require any interface tracking method. The phase change process is based on a stiff relaxation procedure using thermodynamic equilibrium considerations.
Results related to a pump application are then presented using the open-source platform ECOGEN where the present numerical method is implemented. The model is able to produce a quite realistic pump characteristic curve where the relationship between the pump overpressure and its operating mass flow rate is expressed. In these first calculations it will be shown that cavitation may occur in some regions of the flow and that the multiphase approach is suited for this study.