bluuebunny/crossref_metadata_2025_split huggingface dataset:
Holographic ultraviolet nanosecond laser processing using adaptive optics
Authors: Hasegawa Satoshi , Kato Mizuki , Hayasaki Yoshio 
Published: October 2022

Abstract
Fabrication of a through hole in a polyimide film was demonstrated by holographic ultraviolet (UV) nanosecond laser processing with a computer-generated hologram displayed on a phase-only spatial light modulator (SLM). The UV laser was directly modulated into a Bessel beam by a diffractive axicon displayed on the SLM. The direct modulation contributed to improved light-utilization efficiency of the UV laser and a simplified optical setup compared to the conventional method based on a combination of an SLM and harmonic generation using a nonlinear optical crystal. Furthermore, adaptive optics was implemented in holographic laser processing to compensate for aberrations in the optical setup. The proposed method is suitable for improving the throughput and accuracy of drilling, cutting, and additive manufacturing using UV lasers with industrial requirements.
Characteristics, treatment and outcome of patients with bowel perforation after immune checkpoint inhibitor exposure
Authors: Machado Antonio Pizuorno , Shatila Malek , Liu Cynthia , Lu Yang , Altan Mehmet , Oliva Isabella Glitza , Zhao Dan , Zhang Hao Chi , Thomas Anusha , Wang Yinghong 
Published: October 2022

Abstract
Purpose: Exposure to immune checkpoint inhibitors (ICIs) can predispose to immune-related adverse events (irAEs) involving the gastrointestinal tract. The association between ICIs and bowel perforation has not been well studied. We aimed to describe the clinical course, complications, treatment and outcomes of patients experiencing bowel perforation during or after ICI treatment.
Methods: This retrospective, single-center study included adult cancer patients with bowel perforation that occurred between the first dose of ICI treatment and up to 1 years thereafter between 1/1/2010 and 4/30/2021. Patients’ clinical course, imaging, treatment and outcomes related to bowel perforation were collected and analyzed.
Results: Of the 13,991 patients who received ICIs during the study period, 90 (0.6%) met the inclusion criteria. A majority were male (54.4%), the most common cancer type was melanoma (23.3%), and most patients had received PD-1/L1 inhibitor treatment (58.8%). Onset of perforation occurred after a median of 4 ICI treatment cycles. The most common symptom was abdominal pain (95.5%). The colon was the most common location for the perforation (37.7%). Evidence of diverticulitis, enterocolitis, or appendicitis was seen in 32 (35.6%) patients, and 6 (6.6%) patients had luminal cancer involvement at the time of perforation. The overall hospitalization rate related to perforation was 95.5%, with mortality of 15.5% during the same admission. Antibiotics were given in 95% of our sample; 37.8% of patients also required surgical/interventional radiology intervention. Forty-six patients (51.1%) had perforation-related complications (e.g. sepsis, fistula, abscess), which were associated with a higher mortality rate (30%).
Conclusion: Our findings suggest a low incidence of bowel perforation after ICI treatment (0.6%), with 40% of patients having coexisting bowel inflammation as a potential contributing factor. Patients with bowel perforation had an aggressive disease course and high rates of hospitalization, complications and mortality. Early recognition and prompt intervention is critical to improve patient outcomes. Future studies are warranted to further investigate the cause, predictive markers and optimal treatment for this patient population.
Study of tensile mechanical properties of granite after repeated action of high temperature-water cooling
Authors: Zhu Dong , Fan Yuqing , Miao Leigang , Jin Huiwu , Jing Hongwen , Liu Xiaofei 
Published: October 2022

Abstract
In order to investigate the effects of repeated impacts of high temperature-water cooling on the tensile mechanical properties of granite, Brazilian splitting tests were conducted on granite disc specimens after repeatedly experiencing high temperature-water cooling treatment from 250 to 650°C. The load-displacement curves, tensile strength and average stiffness of the specimens were investigated in relation to the temperature and the number of hot and cold impacts, and the crack evolution characteristics of granite specimens after repeated impacts of high temperature-water cooling were investigated. The test results showed that the post-peak brittleness of granite specimens weakened and plasticity increased with the increase of temperature and the number of impact effects, and the tensile strength and average stiffness showed an overall decreasing trend. The cracking load of the specimen showed an overall decreasing trend, the cracking part was transformed from two ends to the middle position, the main crack was transformed from linear to curved and wavy, and the main crack opening gradually increased, the number of secondary cracks gradually increased, and the fracture was transformed from smooth surface to granular scattered structural surface.
miRNA profiling of developing rat retina in the first three postnatal weeks
Authors: Urbán Péter , Pöstyéni Etelka , Czuni Lilla , Herczeg Róbert , Fekete Csaba , Gábriel Róbert , Kovács-Valasek Andrea 
Published: October 2022

Abstract
The morphogenesis of the mammalian retina depends on the precise control of gene expression during development. Small non-coding RNAs, including microRNAs play profound roles in various physiological and pathological processes via their regulation of gene expression. A systematic analysis of the expression profile of small non-coding RNAs in developing Wistar rat retinal tissues was executed using IonTorrent PGM next-generation sequencing technique in order to reveal the crucial players in the early postnatal retinogenesis. Our analysis reveals extensive regulatory potential of microRNAs during retinal development. We found a group of microRNAs that show constant high abundance (rno-mir-19, rno-mir-101; rno-mir-181, rno-mir-183, rno-mir-124 and let-7) during the development process. Others are present only in the early stages (such as rno-mir-20a, rno-mir-206, rno-mir-133, rno-mir-466, rno-mir-1247, rno-mir-3582), or at later stages (rno-mir-29, rno-mir-96, rno-mir-125, rno-mir-344 or rno-mir-664). Further 37 miRNAs were detected which are differentially expressed on consecutive time-points with FDR < 0.05. Eight miRNAs changed significantly by more than 2-fold between time-points. Finally, pathway enrichment analysis has revealed 850 predicted target genes that mainly participate in lipid-, amino acid- and glycan metabolisms. P5-P7 transition revealed the importance of glutamatergic synapse and gap junction KEGG pathways. In these pathways, among significantly down-regulated miRNAs rno-mir-30c1 and 2, rno-mir-205 and rno-mir-503 were detected to target Prkx (ENSRNOG00000003696), Adcy6 (ENSRNOG00000011587), Gnai3 (ENSRNOG00000019465) and Gja1 (ENSRNOG00000000805) genes. The dataset described here will be a valuable resource for clarifying new regulatory mechanisms for retinal development and will greatly contribute to our understanding of the divergence and function of microRNAs.
DEIGASe: Deep Extraction and Information Gain for an Optimal Anomaly Detection in IoT-based Smart Cities
Authors: Hazman Chaimae , azidine Guezzaz , Benkirane Said , Azrour Mourade 
Published: October 2022

Abstract
A smart city architecture involves the integration of information and communication technology with gadgets across a system in order to boost connectivity for residents. As a result of ongoing data collection to improve service to customers. With the availability of multiple devices and remote flow through channels, the probability of cyber-attacks and intrusion detection has increased. As a consequence, numerous solutions for securing IoT have been implemented, including authentication, availability, encryption, and data integrity. Intrusion detection systems (IDSs) are an effective cyber solution that could be expanded by utilizing machine learning (ML) and deep learning (DP) techniques. This study presents an enhanced IDS that makes use of This study provides an optimal anomaly detection model, called DEIGASe which combines deep extraction based on the stacked autoencoder and feature selection utilizing Information gain (IG) and Genetic algorithms (GA) for select best features. The proposed model was evaluated on the upgraded IoT-23, BoT-IoT, and Edge-IIoT datasets using the GPU. When compared to existing IDS, our approach provides good ACC, recall, and precision rating performance features, with over 99.9% on record detection and calculation times around 17s for learning and 0.613s for detection.
Molecule stapling-assisted high-quality CsPbI2Br films for efficient and stable photovoltaic modules
Authors: Chen Ruihao , Du Jieru , Zheng Xuan , Li Feiming , Guo Pengfei , Liu Zhe , Wang Hongqiang 
Published: October 2022

Abstract
CsPbI2Br perovskite solar cells (PSCs) are sutiable bandgap for the fabrication of tandem solar cells as well as excellent thermal stability. However, their halide phase seperation and water instability lead to challenges for practical industrialization. Here, a molecule stapling strategy is demonstrated to assist/stabilize the high-quality large-area CsPbI2Br film by using a series of cesium perfluorodioate salts. According to the density functional theory and experimental attempt hexafluoroglutarate anion possessed more stronger interaction between chelated oxyen and surface Pb2+ ion due to the matchable stapling configuration, which effectively improved moisture tolerance and reduced defects and further improved phase stability of the CsPbI2Br films. In the prepared high-quality Cs-HFG films, the fabricated PSCs achieved 16.4% efficiency in lab scale. And the devices displayed high stability, retained ~91% of the initial efficiency for more than 1000 h under 85 oC and N2 condition, and ~90% for 2000 h at the relative humidity of 20% without encapsulation. More importantly, the developed strategy can be employed for the production of large-area perovskite solar modules. A mini module device with an efficiency up to 12.4% in a large area of 16 cm2 was successfully fabricated.
Risk Factors of Dyspepsia Development during Anti-tuberculosis Chemotherapy in Children
Authors: Bryukhacheva E. O. , Kholodov A. A. , Ivanov V. I. , Kazul G. A. , Pyanzova T. V. 
Published: October 2022

The objective: to identify factors influencing the development of dyspepsia in children during treatment with anti-tuberculosis drugs.Results: out of 243 children during chemotherapy, 22.6% developed dyspepsia as an adverse reaction. Risk factors significantly associated with the development of dyspepsia were as follows: formula feeding at birth, comorbidities of the gastrointestinal tract, decreased total protein and elevated leukocyte counts by the admission to hospital, tuberculosis treatment as per regimens IV or V, and inclusion of protionamide or para-aminosalicylic acid to the regimen. Based on the method of logistic regression, the following has been developed: the method to predict the risk of developing dyspepsia during anti-tuberculosis chemotherapy in children with a sensitivity of 93%; the PC software to calculate such a risk.
jogo pedagógico e as interações multimodais no ensino
Authors: Feiteiro Cavalari Lotti Ana Luisa , Medeiros Sarti Flavia 
Published: October 2022

Este artigo discute a interação entre professores e alunos/estudantes, na sala de aula, que se delineia mediante o jogo pedagógico. O tema é explorado com base em um recorte de uma pesquisa de doutorado, que buscou identificar e caracterizar os elementos constitutivos desse jogo, a saber: os papéis, as regras, as máscaras e o cenário/foco. Os dados da investigação foram reunidos por meio de entrevistas realizadas com duas professoras, as quais atuam na educação básica, uma de Física, do primeiro ano do Ensino Médio, e outra de Geografia, do sexto ano do Ensino Fundamental. No que tange à fundamentação teórica, o trabalho ancora-se em uma concepção multidisciplinar da interação, principalmente das áreas da Educação e da Linguística, e do jogo, explorada a partir de referenciais da filosofia, da sociologia e da história. Objetiva-se, dessa forma, compreender melhor a interação na ação docente e, particularmente, no ensino, atividade fim da docência.
A ATUAÇÃO DA SUPERINTENDÊNCIA DE AÇÕES DE RECUPERAÇÃO URBANA (SARU) NO ÂMBITO DA GESTÃO DA POLÍTICA HABITACIONAL DA COMPANHIA DE DESENVOLVIMENTO HABITACIONAL E URBANO (CDHU) NO ITAIM PAULISTA, SÃO PAULO
Authors: Almeida Eneida de , Andrade Gabriely Lima 
Published: October 2022

A dinâmica socioespacial das favelas está intimamente ligada ao processo de expansão urbana espraiada, caracterizado pela supervalorização de regiões centrais urbanizadas, em contraposição às áreas periféricas marcadas pela disparidade na distribuição de renda, no acesso a serviços de infraestrutura e a equipamentos socioculturais. Além dessas carências generalizadas, esses territórios apresentam sérios problemas ambientais, condições precárias de moradia, enquanto reflexo de ocupações irregulares e clandestinas. Ao planejamento e à gestão da cidade cabe enfrentar o desafio de ofertar a esses moradores condições salubres e dignas de moradia através de políticas públicas sociais. Este texto, produzido como parte de pesquisa de mestrado, tem por objetivo documentar a gestão da política habitacional produzida pela Companhia de Desenvolvimento Habitacional e Urbano (CDHU) no empreendimento São Miguel E - Encosta Norte, situado no distrito Itaim Paulista, na Zona Leste da cidade de São Paulo, em paralelo ao Trabalho Social (TS) realizado no âmbito da Superintendência de Ações de Recuperação Urbana (SARU), em áreas de ocupação irregular, como a da Favela Tijuco Preto, contígua ao referido empreendimento, enquanto formas distintas e complementares de atuação dos programas habitacionais públicos nessa região. O estudo se apoia em uma revisão bibliográfica de autores de reconhecida relevância na reflexão acerca das políticas habitacionais e da própria SARU, valendo-se da documentação da trajetória da CDHU, tendo em vista contribuir para um acúmulo de experiências de gestão compartilhada que se municiem das relações sociais e do modos do habitar cotidiano, com vistas a reformular os modos de planejar e projetar a habitação.
BIBLIOSCOPING - A APLICAÇÃO DA BIBLIOMETRIA E SCOPING REVIEW COMO TÉCNICA DE INVESTIGAÇÃO NA ARQUITETURA
Authors: Gago dos Santos João , Freire Juliane , Cardoso Raquel Vianna Duarte , Boueri José Jorge , Januário Pedro , Almeida Paulo Pereira 
Published: October 2022

Investigar em arquitetura é uma tarefa difícil, diversas são as dificuldades encontradas ao longo do processo de pesquisa. Estes obstáculos ocorrem uma vez que a arquitetura está contida numa área de estudo multidisciplinar. Assim, este artigo propõe apresentar uma sistematização do processo de elaboração do estado da arte, na fase do projeto de tese. O procedimento do Scoping review foi identificado pelos autores como uma ferramenta amplamente utilizada no campo de investigação das ciências médicas e partindo deste ponto foi adaptado para o contexto da investigação em Arquitetura. O objectivo principal é demonstrar as adaptações que foram realizadas ao procedimento e como estas se coadunam com a investigação na arquitectura, através da incorporação de ferramentas de softwares gratuitos que tornam o processo mais sistemático e por conseguinte, mais rápido e simples. O procedimento - Biblioscoping - tem sido aplicado por diversos alunos do doutoramento em arquitetura da Universidade de Lisboa, onde se têm verificado resultados com maior qualidade, rigor e síntese nas pesquisas desenvolvidas, contribuindo para o desenvolvimento de um estado da arte/ enquadramento teórico mais robusto e informado.
O DESENHO COMO TESTEMUNHO E MEMÓRIA DA ARQUITETURA
Authors: Faria Eduarda 
Published: October 2022

RESUMOEste artigo aborda a relação intrínseca e perene entre Desenho e Arquitetura, e as múltiplas formas desta se expressar ao longo do tempo. O ensaio tem como objetivo reafirmar o desenho como forma de desenvolvimento, conhecimento e aprendizagem da Arquitetura e sua História, sublinhando o seu papel fundamental como testemunho e memória da Arquitetura. O desenho permite desvendar, desde logo, o percurso de uma obra de arquitetura, acompanhar o raciocínio do arquiteto e o longo caminho da ideia à obra, através do traço (a lápis ou no ecrâ do computador), documentar as diferentes fases da concepção, expressar a ideia em sucessivos croquis que vão ganhando forma, objetividade e sentido. O desenho, como excelência na arte da representação, revela-se um instrumento universal poderoso, capaz de preservar o património da arquitetura do passado, e a sua memória, quer de arquiteturas existentes ou já desaparecidas. Num mundo privado da fotografia, o desenho desempenhou um papel determinante no levantamento, na preservação e divulgação de obras de arquitetura que se descobriram, por muitos dos talentos que se entregaram ao estudo da Antiguidade, da arquitetura, como Giovanni Battista Piranesi, Jean-Nicolas Huyot, Louis- Hippolyte Lebas, Charles-Robert Cockerell, Michael Gandy, que deixaram no mundo da Arquitetura e do Desenho uma importante obra gráfica. De salientar ainda a relevância do desenho para a História da arquitetura, como testemunho de arquiteturas desenhadas imaginadas não construídas, e imortalizadas em desenhos de mundos fantásticos enigmáticos em Piranesi, ou cidades futuristas muito à frente no seu tempo, como em Antonio Sant’ Elia.
INTERVENÇÕES EM PREEXISTÊNCIAS
Authors: Alves Monica Rosario , Soares de Medeiros Giovani Cícero 
Published: October 2022

O presente artigo propõe detalhar a experiência da disciplina Oficina de Patrimônio, do PPAPMA/ UFRN, ministrada pelos professores doutores Maisa Fernandes Dutra Veloso e José Clewton do Nascimento, que resultou em uma reflexão acerca da preservação e conservação do patrimônio edificado do sítio histórico Natal/RN, através da proposta de projeto em edifício de valor patrimonial, intitulado “Espaço Boca", um edifício de uso misto, elaborado pela equipe de alunos da pós-graduação (PPAPMA e PPGAU) da UFRN, autores deste artigo. As atividades de intervenções partiram de um olhar coletivo da turma (autores: Giovani Medeiros, Jorge Lima, José Idalécio, Laura Oliveira, Monalisa Barreto e Mônica Alves) sobre uma fração urbana, no bairro da Ribeira, Natal/ RN, que resultou na elaboração de um Masterplan. A trajetória metodológica utilizada pelos autores iniciou-se com o estudo da literatura referente as teorias e métodos de intervenção em preexistências, com o suporte de palestras, visita "in loco", a fim de realizar uma apreensão do lugar. Houve uma pesquisa documental que, somada a elaboração de um painel de descobertas das potencialidades e fragilidades encontradas no universo em estudo, norteou o conceito e o partido arquitetônico. Foram realizados estudos de referências projetuais, que contribuíram para a definição da programação arquitetônica e para a concepção das ideias iniciais do projeto. Como resultado, a disciplina Oficina de Projetos de Intervenções no Patrimônio contribuiu para a capacitação profissional dos discentes, no que tange ao processo de projeto em ações de preservação e conservação.
Gelatin-hydroxyapatite Fibrous Nanocomposite for Regenerative Dentistry and bone Tissue Engineering
Authors: Shahi Shahriar , Sharifi Simin , Khalilov Rovshan , Dizaj Solmaz Maleki , Abdolahinia Elaheh Dalir 
Published: October 2022

Aims:
This study aimed to prepare and physicochemically evaluate as well as assess the cytotoxicity and stimulation of early osteogenic differentiation of dental pulp stem cells of gelatin-hydroxyapatite (Gel-HA) fibrous nanocomposite scaffold.

Background:
Recently, the electrospinning approach in nanotechnology has been considered due to its application in the preparation of biomimetic nanofibers for tissue engineering.

Objective:
The main objective of this study was to evaluate Gel-HA fibrous nanocomposite for regenerative dentistry and bone tissue engineering material.

Methods:
The nano-scaffold was prepared via the electrospinning method. Then, the physicochemical properties (particle size, surface charge, morphology, hydrophilicity, specific surface area, crystalline state and the characterization of functional groups) and the proliferative effects of nano-scaffolds on dental pulp stem cells were assessed. The alkaline phosphatase activity was assessed for evaluation of early osteogenic differentiation of dental pulp stem cells.

Results:
The prepared nano-scaffolds had a negative surface charge (-30 mv±1.3), mono-dispersed nano-scale diameter (98 nm±1.2), crystalline state and fibrous uniform morphology without any bead (structural defects). The nanofibrous scaffold showed increased hydrophobicity compared to gelatin nanofibers. Based on Brunauer-Emmett-Teller analysis, the specific surface area, pore volume and pore diameter of Gel-HA nanofibers decreased compared to gelatin nanofibers. The Gel-HA nano-fibers showed the proliferative effect and increased the alkaline phosphatase activity of cells significantly (P<0.05).

Conclusion:
The prepared Gel-HA nanofibers can be considered potential candidates for application in bone tissue engineering and regenerative dentistry.

Other:
Gel-HA nanofibers could be a potential material for bone regeneration and regenerative dentistry in the near future.
Predicting Overweight and Obesity Status Among Malaysian Working Adults With Machine Learning or Logistic Regression: Retrospective Comparison Study
Authors: Wong Jyh Eiin , Yamaguchi Miwa , Nishi Nobuo , Araki Michihiro , Wee Lei Hum 
Published: October 2022

Background
Overweight or obesity is a primary health concern that leads to a significant burden of noncommunicable disease and threatens national productivity and economic growth. Given the complexity of the etiology of overweight or obesity, machine learning (ML) algorithms offer a promising alternative approach in disentangling interdependent factors for predicting overweight or obesity status.

Objective
This study examined the performance of 3 ML algorithms in comparison with logistic regression (LR) to predict overweight or obesity status among working adults in Malaysia.

Methods
Using data from 16,860 participants (mean age 34.2, SD 9.0 years; n=6904, 41% male; n=7048, 41.8% with overweight or obesity) in the Malaysia’s Healthiest Workplace by AIA Vitality 2019 survey, predictor variables, including sociodemographic characteristics, job characteristics, health and weight perceptions, and lifestyle-related factors, were modeled using the extreme gradient boosting (XGBoost), random forest (RF), and support vector machine (SVM) algorithms, as well as LR, to predict overweight or obesity status based on a BMI cutoff of 25 kg/m2.

Results
The area under the receiver operating characteristic curve was 0.81 (95% CI 0.79-0.82), 0.80 (95% CI 0.79-0.81), 0.80 (95% CI 0.78-0.81), and 0.78 (95% CI 0.77-0.80) for the XGBoost, RF, SVM, and LR models, respectively. Weight satisfaction was the top predictor, and ethnicity, age, and gender were also consistent predictor variables of overweight or obesity status in all models.

Conclusions
Based on multi-domain online workplace survey data, this study produced predictive models that identified overweight or obesity status with moderate to high accuracy. The performance of both ML-based and logistic regression models were comparable when predicting obesity among working adults in Malaysia.