bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qualitative exploration of patient and healthcare professional perspectives on barriers and facilitators to foot self-care behaviors in diabetes
Authors: Hill Andrew , Ellis Mairghread , Gillison Fiona 
Published: November 2022

IntroductionDiabetic foot ulcers contribute significantly to morbidity and mortality associated with diabetes, but are preventable with good foot self-care. This study sought to explore the perspectives of patients and healthcare professionals (HCPs) on barriers and/or facilitators to foot self-care behaviors in diabetes and areas of consensus and/or tension between patient and HCP perspectives.Research design and methodsThis was a sequential, qualitative study that used a hermeneutic phenomenological approach. Phase I involved nine in-depth, semi-structured patient interviews. Phase II involved seven in-depth semi-structured interviews with HCPs (podiatrists, diabetes nurses, foot health practitioners (FHPs) and general practitioners (GPs)). In phase III, findings from phases I and II were brought back to two patient interview groups (five patients in total) to try and identify any areas of consensus and tension between HCP and patient perspectives.ResultsPatient and HCP perspectives had several areas of alignment: concerns over consequences of diabetes complications; the importance of patient education and frustrations around aspects of health service delivery. There were also some notable tensions identified: mixed messaging from HCPs around whose responsibility patient foot health is; and who patients should initially consult following the development of a foot problem. Overall, patients expressed that motivation to undertake good foot self-care behaviors was generated from their lived experiences, and was enhanced when this aligned with the information they received from HCPs. HCPs appeared to attribute lack of patient motivation to lack of knowledge, which was not raised by patients.ConclusionsThis study has identified points of misalignment between the views of patients and practitioners that may help to explain why adherence to foot self-care among patients with diabetes is low. Our results suggest that better outcomes may stem from HCPs focusing on supporting autonomous motivation for self-care and enhancing the rationale through referencing patients’ own experience rather than focussing on increasing patient knowledge. Renewed focus on consistency of messaging by HCPs around the roles and responsibilities relating to foot health in diabetes, and the benefit of foot-specific training being provided to non-foot specialist HCPs may also help to improve uptake and adherence to foot self-care behaviors in diabetes.
Cross-sectional study on prevalence and risk factors for falls among the elderly in communities of Guangdong province, China
Authors: Lin Xia-zi , Meng Rui-lin , Peng Dan-dan , Li Chuan , Zheng Xue-yan , Xu Hao-feng , Xu Xiao-jun , Lin Li-feng 
Published: November 2022

ObjectiveThis study aims to investigate the prevalence and risk factors of falls among the elderly in Guangdong, China.MethodsA cross-sectional study was conducted in six communities of Guangdong province. People over 60 years old were selected with multistage random-cluster sampling. Data on falls within the previous 12 months and fall-related risk factors were collected through a face-to-face interview.ResultsThe prevalence of falls among older adults was 11.9% (95% CI: 11.0% to 12.8%) among 5374 interviewees. The common injuries caused by falls were bruises/scrapes (40.0%) and fractures (15.5%), and most people fall while doing housework (35.0%). Univariate analysis showed that 14 factors were associated with falls among older adults, including gender, age, residence, occupation, education level, balance ability, situation of cognition, disease, depression, living arrangement, marital status, the behaviour of exercise, drinking and drug use (p<0.05). Multivariate analysis showed that the associated factors of falls among older adults included woman (OR=1.68, 95% CI: 1.40 to 2.02), age from 70 to 79 years (OR=1.31, 95% CI: 1.09 to 1.58), age over 80 (OR=1.63, 95% CI: 1.25 to 2.13), impaired balance ability (OR=1.45, 95% CI: 1.20 to 1.75), exercise several times per month (OR=1.69, 95% CI: 1.13 to 2.53), polypharmacy (OR=1.54, 95% CI: 1.19 to 2.00), cognition impairment (OR=1.35, 95% CI: 1.08 to 1.69), mild depression (OR=1.89, 95% CI: 1.47 to 2.45) and moderate depression (OR=3.07, 95% CI: 1.99 to 4.73).ConclusionsThe hazards caused by falls to the elderly in China cannot be ignored. A multidimensional customised fall prevention programme should be considered to reduce the risk of falls among the elderly based on the results above.
Effect of a board game about sexually transmitted infections on imprisoned women’s knowledge: protocol for a quasi-experimental study
Authors: Carvalho Isaiane da Silva , Mendes Ryanne Carolynne Marques Gomes , Souza Soares Lima Laís Helena de , Leal Luciana Pedrosa , Guedes Tatiane Gomes , Linhares Francisca Márcia Pereira 
Published: November 2022

IntroductionThe prevalence of sexually transmitted infections in imprisoned women is high. In the prison school context, education in health is one of the best strategies to achieve positive indicators in terms of health promotion and disease prevention. The use of educational technologies, such as board games, can aid in the process of knowledge acquisition on a given subject matter. This article describes the protocol of a health educational intervention that addresses content about sexually transmitted infections directed to imprisoned women in a prison school.Methods and analysisA quasi-experimental study to test the effect of a board game on 64 imprisoned women’s level of knowledge about sexually transmitted infections. The Previna board game was specifically created and validated for these women. The primary outcome will be the level of knowledge on sexually transmitted infections, measured using a score obtained after the assessment conducted during the initial interview, immediately after the intervention and after 15 days.Ethics and disclosureThis study was approved by the Research Ethics Committee of the Federal University of Pernambuco (Opinion No. 3 986 050 and CAAE: 30035520.7.0000.5208). The results will be presented to the school and to the Federal University of Pernambuco, as part of the activities of a PhD Thesis in Nursing, and will be disclosed in peer-reviewed journals and scientific events.Trial registration numberRBR-2JWS7DV.
Accelerated menopausal changes as human disease model ‘FOCUM’ for the development of osteoarthritis and other degenerative disorders: protocol for a prospective cohort study
Authors: Molendijk Eveline , Schiphof Dieuwke , Oei Edwin H G , de Vos Robert-Jan , Bos P Koen , van Meurs Joyce B J , Lubberts Erik , Zillikens M Carola , van der Eerden Bram C J , Kavousi Maryam , Schouten Boris W V , de Rooij-Duran Mariëlla I B , Bierma-Zeinstra Sita M A 
Published: November 2022

IntroductionThe incidence of degenerative disorders, including osteoarthritis (OA), increases rapidly in women after menopause. However, the influence of the menopause is still insufficiently investigated due to the slowness of menopausal transition. In this study, a novel human model is used in which it is expected that menopausal-related changes will occur faster. This is the Females discontinuing Oral Contraceptives Use at Menopausal age model. The ultimate aim is to link these changes to OA and other degenerative disorders, including cardiovascular diseases, diabetes, osteoporosis and tendinopathies.Methods and analysisThis is a pilot observational prospective cohort study with 2 years of follow-up. Fifty women aged 50–60 who use oral contraceptive (OC) and have the intention to stop are included. Measurements are performed once before stopping OC, and four times thereafter at 6 weeks, 6 months, 1 year and 2 years. At every time point, a questionnaire is filled in and a sample of blood is drawn. At the first and final time points, a physical examination, hand radiographs and a MRI scan of one knee are performed. The primary OA outcome is progression of the MRI Osteoarthritis Knee Score. Secondary OA outcomes are the development of clinical knee and hand OA, development of knee OA according to the MRI definition, and progression of radiographic features for hand OA. Principal component analysis will be used to assess which changes occur after stopping OC. Univariate and multivariate generalised estimating equation models will be used to test for associations between these components and OA.Ethics and disseminationThe study has been approved by the Medical Ethics Committee of the Erasmus MC University Medical Center Rotterdam (MEC-2019-0592). All participants must give informed consent before data collection. Results will be disseminated in national and international journals.Trial registration numberNL70796.078.19.
Consequences of SARS-CoV-2 pandemic on urological surgery in France: a nationwide analysis of the healthcare system database
Authors: Robert Gregoire , Bernhard Jean-Christophe , Capon Grégoire , Alezra Eric , Estrade Vincent , Blanc Peggy , Bladou Franck , Bensadoun Henri 
Published: November 2022

The SARS-CoV-2 outbreak overwhelmed the healthcare systems worldwide. Saturation of hospitals and the risk of contagion led to a reduction in the care of other diseases.ObjectiveTo determine the impact of SARS-CoV-2 pandemic on urological surgery in France during the year 2020.Design, setting and participantsAn observational descriptive study was conducted on anonymised data collected from the national healthcare database established each year as part of the Program for the Medicalization of Information Systems in Medicine, Surgery, Obstetrics and Odontology.InterventionNone.Primary and secondary outcome measuresWe gathered the number of urology surgical procedures carried out between 2010 and 2019, and we observed the difference between the forecast and actual number of urological surgeries performed in 2020.ResultsUrological surgeries decreased by 11.4%, non-oncological surgeries being more affected (−13.1%) than oncological ones (−4.1%). Among the most relevant surgeries, female urinary incontinence (−44.7%) and benign prostatic hyperplasia (−20.8%) were the most impacted ones, followed by kidney cancer (−9%), urolithiasis (−8.7%), radical cystectomy for bladder cancer (−6.1%), prostate cancer (−3.6%) and transurethral resection of bladder tumour (−2%). Public hospitals had a more reduced activity (−17.7%) than private ones (−9.1%). Finally, the distribution of the reduction in urological activities by region did not correspond to the regional burden of SARS-CoV-2.ConclusionsUrological care was severely affected during SARS-CoV-2 pandemic. Even if oncological surgeries were prioritised, the longer it takes to receive appropriate care, the greater the risk on survival impact.Trial registrationThe data collection and analysis was authorised by the French Data Protection Authority (CNIL) under the number1 861 282v2.
‘Give me something meaningful’: GPs perspectives on how to improve an audit and feedback report provided by health insurers – an exploratory qualitative study
Authors: de Bekker P J G M , de Weerdt V , Vink M D H , van der Kolk A B , Donker M H , van der Hijden E J E 
Published: November 2022

BackgroundAudit and feedback (A&F) is a valuable quality improvement strategy, which can contribute to de-implementation of low-value care. In the Netherlands, all health insurers collaboratively provide A&F to general practitioners (GPs), the ‘Primary Care Practice Report’ (PCPR). Unfortunately, the use of this report by GPs is limited. This study examined the thoughts of GPs on the usability of the PCPR and GPs recommendations for improving the PCPR.MethodWe used an interpretative qualitative design, with think-aloud tasks to uncover thoughts of GPs on the usability of the PCPR and semistructured interview questions to ask GPs’ recommendations for improvement of the PCPR. Interviews were audiorecorded and transcribed ad verbatim. Data were analysed using thematic content analysis.ResultsWe identified two main themes: ‘poor usability of the PCPR’, and ‘minimal motivation to change based on the PCPR’. The GPs found the usability of the PCPR poor due to the feedback not being clinically meaningful, the data not being recent, individual and reliable, the performance comparators offer insufficient guidance to assess clinical performance, the results are not discussed with peers and the definitions and visuals are unclear. The GPs recommended improving these issues. The GPs motivation to change based on the PCPR was minimal.ConclusionsThe GPs evaluated the PCPR as poorly usable and were minimally motivated to change. The PCPR seems developed from the perspective of the reports’ commissioners, health insurers, and does not meet known criteria for effective A&F design and user-centred design. Importantly, the GPs did state that well-designed feedback could contribute to their motivation to improve clinical performance.Furthermore, the GPs stated that they receive a multitude of A&F reports, which they hardly use. Thus, we see a need for policy makers to invest in less, but more usable A&F reports.
Development of a core minimum data set to advance real-world evidence generation for uterine fibroids treatment technologies
Authors: Baird Courtney E , Myers Evan , Jacoby Vanessa , Gressler Laura Elisabeth , Venable Sateria , O'Neill Allison , Price Veronica , Lee Angie , Roberts Jason , Andrews Sharon , Sedrakyan Art , Marinac-Dabic Danica 
Published: November 2022

ObjectivesThe accumulation of data through a prospective, multicenter coordinated registry network (CRN) is a robust and cost-effective way to gather real-world evidence on the performance of uterine fibroids treatment technologies for device-based and intervention-based studies. To develop the CRN, a group of uterine fibroids experts, consisting of representatives from professional societies, the US Food and Drug Administration, academia, industry, and the patient community, was convened to discuss the role and feasibility of the CRN and to identify the core data elements needed to assess uterine fibroid treatment technologies.DesignA Delphi method approach was employed to achieve consensus on a core minimum data set for the CRN. A series of surveys were sent to the panel and answered by each expert anonymously and individually. Results from the surveys were collected, collated, and analyzed by a study design team from Weill Cornell Medicine. Questions for the next round were based on the analysis process and discussed with group members via a conference call. This process was repeated twice over a 3-month time period until consensus was achieved.ResultsTwenty-nine experts participated in the Delphi surveys, which began with an initial list of 200 data elements. The working group reached final consensus on 97 data elements capturing patient medical history, imaging data, procedure-related data, post-procedure data, and long-term follow-up data.ConclusionsThe CRN successfully convened an expert panel on uterine fibroids treatment technologies and used the Delphi method to produce a consensus-based core set of data elements. These identified data elements include important outcomes related to efficacy and safety and thus, influence patient, provider, and regulatory decision-making about treatments for uterine fibroids. Finally, the core data elements provide the foundation of the infrastructure needed for the CRN that will allow for the comparative study of uterine fibroid treatment devices and technologies.
The ARTI framework: cosmic rays atmospheric background simulations
Authors: Sarmiento-Cano Christian , Suárez-Durán Mauricio , Calderón-Ardila Rolando , Vásquez-Ramírez Adriana , Jaimes-Motta Andrei , Núñez Luis A. , Dasso Sergio , Sidelnik Iván , Asorey Hernán ,   For the LAGO Collaboration
Published: November 2022

AbstractARTI is a complete framework designed to simulate the signals produced by the secondary particles emerging from the interaction of single, multiple, and even from the complete flux of primary cosmic rays with the atmosphere. These signals are simulated for any particle detector located at any place (latitude, longitude and altitude), including the real-time atmospheric, geomagnetic and detector conditions. Formulated through a sequence of codes written in C++, Fortran, Bash and Perl, it provides an easy-to-use integration of three different simulation environments: MagnetoCosmics, CORSIKA and Geant4. These tools evaluate the geomagnetic field effects on the primary flux and simulate atmospheric showers of cosmic rays and the detectors’ response to the secondary flux of particles. In this work, we exhibit the usage of the ARTI framework by calculating the total expected signal flux at eight selected sites of the Latin American Giant Observatory: a cosmic ray Observatory all over Latin America covering a wide range of altitudes, latitudes and geomagnetic rigidities. ARTI will also calculate the signal flux expected during the sudden occurrence of a gamma-ray burst or the flux of energetic photons originating from steady gamma sources. It also compares these fluxes with the expected background when they are detected in a single water Cherenkov detector deployed in a high-altitude site. Furthermore, by using ARTI, it is possible to calculate in a very precise way the expected flux of high-energetic muons and other secondaries at the ground level and to inject them through geological structures for muography applications.
Locally conformal SKT structures
Authors: Djebbar Bachir , Ferreira Ana Cristina , Fino Anna , Youcef Nourhane Zineb Larbi 
Published: November 2022

A Hermitian metric on a complex manifold is called SKT (strong Kähler with torsion) if the Bismut torsion 3-form [Formula: see text] is closed. As the conformal generalization of the SKT condition, we introduce a new type of Hermitian structure, called locally conformal SKT (or shortly LCSKT). More precisely, a Hermitian structure [Formula: see text] is said to be LCSKT if there exists a closed nonzero [Formula: see text]-form [Formula: see text] such that [Formula: see text]. In this paper, we consider nontrivial LCSKT structures, i.e. we assume that [Formula: see text] and we study their existence on Lie groups and their compact quotients by lattices. In particular, we classify six-dimensional nilpotent Lie algebras admitting a LCSKT structure and we show that, in contrast to the SKT case, there exists a six-dimensional 3-step nilpotent Lie algebra admitting a nontrivial LCSKT structure. Moreover, we show a characterization of even dimensional almost abelian Lie algebras admitting a nontrivial LCSKT structure, which allows us to construct explicit examples of six-dimensional unimodular almost abelian Lie algebras admitting a nontrivial LCSKT structure. The compatibility between the LCSKT and the balanced condition is also discussed, showing that a Hermitian structure on a six-dimensional nilpotent or a [Formula: see text]-dimensional almost abelian Lie algebra cannot be simultaneously LCSKT and balanced, unless it is Kähler.
Development of Near-Field Earthquake Loading Protocols for the Steel Moment Connections in Iran
Authors: Alizehi Elyas , Ghassemieh Mehdi , Mirghaderi Seyed Rasoul , Ali Mahmoud Ali 
Published: November 2022

Steel moment frame buildings are widely used in Iran and around the world. The observations from major earthquakes underscored the importance of the beam-to-column connections in seismic force-resisting systems and their influence on such building’s performance. Since the most catastrophic earthquakes that occurred in Iran contained the characteristics of near-field earthquakes, hence understanding the behavior of these connections under such earthquakes is needed. This study proposed loading protocols for special steel moment-resisting frame systems under near-field earthquakes in Iran. Each of them had 23 damage half-cycles with a maximum inter-story drift of 0.065 radians. The proposed loading protocols were compared numerically to each other. The most influential one was chosen as the main loading protocol since it has the most destructive effect on the connection. The main loading protocol showed a faster rate of increase in the plastic strain and imposed the highest amount of dissipated energy at a former loading stage compared to other near-field earthquake loading protocols related to other countries such as SAC and Fang et al.
Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer
Authors: Chen Huang , Zhou Wenbo , Bian Aiwu , Zhang Qiansen , Miao Ying , Yin Xuan , Ye Jiangnan , Xu Shifen , Ti Chaowen , Sun Zhenliang , Zheng Jianghua , Chen Yihua , Liu Mingyao , Yi Zhengfang 
Published: November 2022

AbstractPurpose:Pancreatic cancer is the worst prognosis among all human cancers, and novel effective treatments are urgently needed. Signal transducer and activator of transcription 3 (STAT3) has been demonstrated as a promising target for pancreatic cancer. Meanwhile, selectively targeted STAT3 with small molecule remains been challenging.Experimental Design:To specifically identify STAT3 inhibitors, more than 1.3 million compounds were screened by structure-based virtual screening and confirmed with the direct binding assay. The amino acid residues that WB436B bound to were verified by induced-fit molecular docking simulation, RosettaLigand computations, and site-directed mutagenesis. On-target effects of WB436B were examined by microscale thermophoresis, surface plasmon resonance, in vitro kinase assay, RNA sequencing, and selective cell growth inhibition assessment. In vivo studies were performed in four animal models to evaluate effects of WB436B on tumor growth and metastasis. Kaplan–Meier analyses were used to assess survival.Results:WB436B selectively bound to STAT3 over other STAT families protein, and in vitro antitumor activities were improved by 10 to 1,000 fold than the representative STAT3 inhibitors. WB436B selectively inhibits STAT3-Tyr705 phosphorylation, STAT3 target gene expression, and the viability of STAT3-dependent pancreatic cancer cells. WB436B significantly suppresses tumor growth and metastasis in vivo and prolongs survival of tumor-bearing mice. Mechanistic studies showed that WB436B have unique binding sites located in STAT3 Src homology 2 domain.Conclusions:Our work presents the first-in-class selective STAT3 inhibitor WB436B as a potential therapeutic candidate for the treatment of pancreatic cancer.