bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technological and Scientific Prospection on Pigments Produced by
Microorganisms
Authors: de Souza Tainã Lima Silva , de Souza Carolina Oliveira , Umsza-Guez Marcelo Andrés 
Published: November 2022

Background:
Interest in natural pigments has grown due to the negative aspects
caused by synthetic options, which trigger damage to the body and the environment. Research
with natural pigments produced by microorganisms becomes viable in relation to
other pigments extracted from animals or plants, as microorganisms have advantages in
terms of versatility and productivity. Thus, production technologies are protected by patents.

Methods:
To evaluate the evolution of research and technological development on producing
natural pigments by different microorganisms through scientific and technological prospection.
Scientific prospecting was done by searching articles published from 2010 to
2020 in the Scopus, Science Direct, and Web of Science databases. Technological prospecting
was carried out with patents obtained from the European Patent Office
(ESPACENET) database.

Results:
The searches were based on the keywords “pigment” and “dye” crossed with microalgae,
fungi, bacteria and yeast. A total of 2.811 articles and 451 patents were selected.
Scientific prospecting has shown interest in alternative cultivation media, and among the
microorganisms that produce pigments, fungi and microalgae are the most studied.

Conclusion:
Technological prospecting showed that 375 (83%) recovered patent documents
refer to the protection of pigment extraction and production techniques and that the
largest patent holders are private companies, followed by Chinese universities.
Review on Lubrication and Sealing Technology of High-Speed Motorized
Spindle
Authors: Gao Yanhua , Dai Ye , Wang Gang , Li Zhaolong , Tao Xueshi 
Published: November 2022

Background:
While the CNC (Computerised Numerical Control) machine spindle is
driving the tool to cut the workpiece, impurities such as cutting fluid splash, metal chips, or metal
dust tend to enter the internal system of the spindle. Optimization of the spindle sealing design can
significantly improve the durability of the motorized spindle. A high-speed motorized spindle is the
primary heat source of CNC machine tools. Under current conditions, a cooling and lubrication system
is the main measure to control the heat of a high-speed motorized spindle.

Objectives:
This paper introduces the current research progress in bearing lubrication and new spindle
sealing structures.

Methods:
The research on bearing lubrication is sorted by comparing the relevant literature on bearing
lubrication; some sealing structures are introduced by giving examples of patents on motorized
spindle seals.

Results:
This paper reviews the bearing lubrication research and spindle sealing structure and provides
an outlook on the future development of bearing lubrication technology and spindle sealing
structure.

Conclusion:
The High-speed motorized spindle is the primary heat source of CNC machine tools.
Bearing lubrication can effectively control the motorized spindle heat; a motorized spindle sealing
structure can prevent impurities from causing damage to the internal parts of the spindle and improve
the service life of the motorized spindle.
Recent Advances in Organocatalytic Methods for the Synthesis of Deuterated
Aldehydes
Authors: Dhayalan Vasudevan 
Published: November 2022

Abstract:
Formyl-selective deuteration of aldehydes is one of the important synthetic methods in the
field of medicinal chemistry. Aldehyde-d is often used as an important building block for pharmaceutical
and drug synthesis due to its versatile reactivity and applicability. Due to the recent interest and development
in the use of deuterated pharma drugs, there is an urgent need for simple and practical synthetic
methods that are effective in producing a broad range of highly deuterated (up to 99% D) functionalized
aryl, heteroaryl, alkyl, and alkenyl aldehyde moieties. Organocatalytic processes mediated by
NHC have recently been used to achieve selective deuterium labelling processes; this system is frequently
used to analyze drug distribution, metabolism, absorption, and excretion (ADME). Moreover,
deuterated pharmaceutical compounds are designed to develop therapeutic effectiveness and reduce
significant side effects and toxicity by increasing the half-life of the isotope drug response. Remarkably,
in 2019-2022, NHC-mediated various catalytic approaches have been dramatically developed. One such
method is a practical and mild synthesis of functionalized deuterated aldehydes, drug molecules, therapeutic
agents, small and complex natural products, and their analogues using a green method in the
presence of water-d as a cheap reagent. These modern methods prepared deuterated drug scaffolds such
as 3-formyl rifamycin, midecamycin, menthol, ibuprofen, naproxen, etc. In this concern, we could provide
a succinct description of the NHC-organocatalyzed modern synthetic strategies, as well as a mild
greener approach for the functional group-selective deuterium isotopic labeling of various formyl compounds
using commercially available deuterium sources (D2O and CD3OD).
Establishing Requirements for Technology to Support Clinical Trial Retention: Systematic Scoping Review and Analysis Using Self-determination Theory
Authors: Gamble Eoin , Linehan Conor , Heavin Ciara 
Published: November 2022

Background
Retaining participants in clinical trials is an established challenge. Currently, the industry is moving to a technology-mediated, decentralized model for running trials. The shift presents an opportunity for technology design to aid the participant experience and promote retention; however, there are many open questions regarding how this can be best supported. We advocate the adoption of a stronger theoretical position to improve the quality of design decisions for clinical trial technology to promote participant engagement.

Objective
This study aimed to identify and analyze the types of retention strategies used in published clinical trials that successfully retain participants.

Methods
A systematic scoping review was carried out on 6 electronic databases for articles published from 1990 to September 2020, namely CINAHL, The Cochrane Library, EBSCO, Embase, PsycINFO, and PubMed, using the concepts “retention,” “strategy,” “clinal trial,” and “clinical research.” This was followed by an analysis of the included articles through the lens of self-determination theory, an evidence-based theory of human motivation.

Results
A total of 26 articles were included in this review. The motivational strategies identified in the clinical trials in our sample were categorized into 8 themes: autonomy; competence; relatedness; controlled motivation; branding, communication material, and marketing literature; contact, tracking, and scheduling methods and data collection; convenience to contribute to data collection; and organizational competence. The trials used a wide range of motivational strategies. Notably, the trials often relied on controlled motivation interventions and underused strategies to support intrinsic motivation. Moreover, traditional clinical trials relied heavily on human interaction and “relatedness” to support motivation and retention, which may cause problems in the move to technology-led decentralized trials. We found inconsistency in the data-reporting methods and that motivational theory–based approaches were not evident in strategy design.

Conclusions
This study offers direction and a framework to guide digital technology design decisions for future decentralized clinical trials to enhance participant retention during clinical trials. This research defines previous clinical trial retention strategies in terms of participant motivation, identifies motivational strategies, and offers a rationale for selecting strategies that will improve retention. It emphasizes the benefits of using theoretical frameworks to analyze strategic approaches and aid decision-making to improve the quality of technology design decisions.
Development and Evaluation of Health Recommender Systems: Systematic Scoping Review and Evidence Mapping
Authors: Sun Yue , Zhou Jia , Ji Mengmeng , Pei Lusi , Wang Zhiwen 
Published: November 2022

Background
Health recommender systems (HRSs) are information retrieval systems that provide users with relevant items according to the users’ needs, which can motivate and engage users to change their behavior.

Objective
This study aimed to identify the development and evaluation of HRSs and create an evidence map.

Methods
A total of 6 databases were searched to identify HRSs reported in studies from inception up to June 30, 2022, followed by forward citation and grey literature searches. Titles, abstracts, and full texts were screened independently by 2 reviewers, with discrepancies resolved by a third reviewer, when necessary. Data extraction was performed by one reviewer and checked by a second reviewer. This review was conducted in accordance with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) statement.

Results
A total of 51 studies were included for data extraction. Recommender systems were used across different health domains, such as general health promotion, lifestyle, and generic health service. A total of 23 studies had reported the use of a combination of recommender techniques, classified as hybrid recommender systems, which are the most commonly used recommender techniques in HRSs. In the HRS design stage, only 10 of 51 (19.6%) recommender systems considered personal preferences of end users in the design or development of the system; a total of 29 studies reported the user interface of HRSs, and most HRSs worked on users’ mobile interfaces, usually a mobile app. Two categories of HRS evaluations were used, and evaluations of HRSs varied greatly; 62.7% (32/51) of the studies used the offline evaluations using computational methods (no user), and 33.3% (17/51) of the studies included end users in their HRS evaluation.

Conclusions
Through this scoping review, nonmedical professionals and policy makers can visualize and better understand HRSs for future studies. The health care professionals and the end users should be encouraged to participate in the future design and development of HRSs to optimize their utility and successful implementation. Detailed evaluations of HRSs in a user-centered approach are needed in future studies.
The Use of 2 e-Learning Modalities for Diabetes Education Using Facebook in 2 Cities of Argentina During the COVID-19 Pandemic: Qualitative Study
Authors: Moyano Daniela Luz , Lopez María Victoria , Cavallo Ana , Candia Julia Patricia , Kaen Aaron , Irazola Vilma , Beratarrechea Andrea 
Published: November 2022

Background
The COVID-19 pandemic and the confinement that was implemented in Argentina generated a need to implement innovative tools for the strengthening of diabetes care. Diabetes self-management education (DSME) is a core element of diabetes care; however, because of COVID-19 restrictions, in-person diabetes educational activities were suspended. Social networks have played an instrumental role in this context to provide DSME in 2 cities of Argentina and help persons with diabetes in their daily self-management.

Objective
The aim of this study is to evaluate 2 diabetes education modalities (synchronous and asynchronous) using the social media platform Facebook through the content of posts on diabetes educational sessions in 2 cities of Argentina during the COVID-19 pandemic.

Methods
In this qualitative study, we explored 2 modalities of e-learning (synchronous and asynchronous) for diabetes education that used the Facebook pages of public health institutions in Chaco and La Rioja, Argentina, in the context of confinement. Social media metrics and the content of the messages posted by users were analyzed.

Results
A total of 332 messages were analyzed. We found that in the asynchronous modality, there was a higher number of visualizations, while in the synchronous modality, there were more posts and interactions between educators and users. We also observed that the number of views increased when primary care clinics were incorporated as disseminators, sharing educational videos from the sessions via social media. Positive aspects were observed in the posts, consisting of messages of thanks and, to a lesser extent, reaffirmations, reflections or personal experiences, and consultations related to the subject treated. Another relevant finding was that the educator/moderator role had a greater presence in the synchronous modality, where posts were based on motivation for participation, help to resolve connectivity problems, and answers to specific user queries.

Conclusions
Our findings show positive contributions of an educational intervention for diabetes care using the social media platform Facebook in the context of the COVID-19 pandemic. Although each modality (synchronous vs asynchronous) could have differential and particular advantages, we believe that these strategies have potential to be replicated and adapted to other contexts. However, more documented experiences are needed to explore their sustainability and long-term impact from the users' perspective.
Multifactor Quality and Safety Analysis of Antimicrobial Drugs Sold by Online Pharmacies That Do Not Require a Prescription: Multiphase Observational, Content Analysis, and Product Evaluation Study
Authors: Mackey Tim Ken , Jarmusch Alan K , Xu Qing , Sun Kunyang , Lu Aileen , Aguirre Shaden , Lim Jessica , Bhakta Simran , Dorrestein Pieter C 
Published: November 2022

Background
Antimicrobial resistance is a significant global public health threat. However, the impact of sourcing potentially substandard and falsified antibiotics via the internet remains understudied, particularly in the context of access to and quality of common antibiotics. In response, this study conducted a multifactor quality and safety analysis of antibiotics sold and purchased via online pharmacies that did not require a prescription.

Objective
The aim of this paper is to identify and characterize “no prescription” online pharmacies selling 5 common antibiotics and to assess the quality characteristics of samples through controlled test buys.

Methods
We first used structured search queries associated with the international nonproprietary names of amoxicillin, azithromycin, amoxicillin and clavulanic acid, cephalexin, and ciprofloxacin to detect and characterize online pharmacies offering the sale of antibiotics without a prescription. Next, we conducted controlled test buys of antibiotics and conducted a visual inspection of packaging and contents for risk evaluation. Antibiotics were then analyzed using untargeted mass spectrometry (MS). MS data were used to determine if the claimed active pharmaceutical ingredient was present, and molecular networking was used to analyze MS data to detect drug analogs as well as possible adulterants and contaminants.

Results
A total of 109 unique websites were identified that actively advertised direct-to-consumer sale of antibiotics without a prescription. From these websites, we successfully placed 27 orders, received 11 packages, and collected 1373 antibiotic product samples. Visual inspection resulted in all product packaging consisting of pill packs or blister packs and some concerning indicators of potential poor quality, falsification, and improper dispensing. Though all samples had the presence of stated active pharmaceutical ingredient, molecular networking revealed a number of drug analogs of unknown identity, as well as known impurities and contaminants.

Conclusions
Our study used a multifactor approach, including web surveillance, test purchasing, and analytical chemistry, to assess risk factors associated with purchasing antibiotics online. Results provide evidence of possible safety risks, including substandard packaging and shipment, falsification of product information and markings, detection of undeclared chemicals, high variability of quality across samples, and payment for orders being defrauded. Beyond immediate patient safety risks, these falsified and substandard products could exacerbate the ongoing public health threat of antimicrobial resistance by circulating substandard product to patients.
Online Health Information Seeking Among Patients With Chronic Conditions: Integrating the Health Belief Model and Social Support Theory
Authors: Zhao Yuxiang Chris , Zhao Mengyuan , Song Shijie 
Published: November 2022

Background
Chronic diseases are the leading causes of death and disability. With the growing patient population and climbing health care expenditures, researchers and policy makers are seeking new approaches to improve the accessibility of health information on chronic diseases while lowering costs. Online health information sources can play a substantial role in effective patient education and health communication. However, some contradictory evidence suggests that patients with chronic conditions may not necessarily seek online health information.

Objective
This study aims to integrate 2 theories (ie, the health belief model and social support theory) and a critical health literacy perspective to understand online health information seeking (OHIS) among patients with chronic conditions.

Methods
We used the survey method to collect data from online chronic disease communities and groups on social media platforms. Eligible participants were consumers with at least 1 chronic condition and those who have experience with OHIS. A total of 390 valid questionnaires were collected. The partial least squares approach to structural equation modeling was employed to analyze the data.

Results
The results suggested that perceived risk (t=3.989, P<.001) and perceived benefits (t=3.632, P<.001) significantly affected patients’ OHIS. Perceived susceptibility (t=7.743, P<.001) and perceived severity (t=8.852, P<.001) were found to influence the perceived risk of chronic diseases significantly. Informational support (t=5.761, P<.001) and emotional support (t=5.748, P<.001) also impacted the perceived benefits of online sources for patients. In addition, moderation analysis showed that critical health literacy significantly moderated the link between perceived risk and OHIS (t=3.097, P=.002) but not the relationship between perceived benefits and OHIS (t=0.288, P=.774).

Conclusions
This study shows that the health belief model, when combined with social support theory, can predict patients’ OHIS. The perceived susceptibility and severity can effectively explain perceived risk, further predicting patients’ OHIS. Informational support and emotional support can contribute to perceived benefits, thereby positively affecting patients’ OHIS. This study also demonstrated the important negative moderating effects of critical health literacy on the association between perceived risk and OHIS.
Penambahan Boraks dalam Bakso dan Faktor Pendorong Penggunaannya Bagi Pedagang Bakso di Kota Bengkulu
Authors: Istiqomah Siti , Sudarwanto Mirnawati B , Sudarnika Etih 
Published: November 2022

The research of using borax in meatballs which was undertaken in the Bengkulu City in 2011 showed that 10% from 100 samples of meatballs containing borax. Considering the dangers of borax for the consumer if consume continuously and increasing the number of meatball traders until 2013, it is necessary to study with more meatballs samples and widely area. The aim of the study was to detect the presence of borax in meatballs, borax content after heating, storability meatballs which containing borax and determine the factors that support the meatball traders to use borax. The study was designed using cross sectional study using two types of data, they were data of meatball sample test in the laboratory and interview data to meatball traders in the BengkuluCity. Total of 160 meatball samples from traders and five meatball samples from grinders were collected and examined with qualitative test using turmeric paper. The qualitative test showed that 165 samples (100%) takenfrom meatball traders and grinders didn't contain borax. Knowledge and attitudes level of traders were at a good level. There were significant relationship between education level with knowledge, information source fromtelevision with attitude, and knowledge with attitude of traders in Bengkulu City (p < 0,05).
Identifikasi Listeria monocytogenes pada Susu Kambing di Kabupaten Purworejo Jawa Tengah
Authors: Andriani Monika Danaparamitha , Purnawarman Trioso , Damayanti Retno , Daulay Syafril 
Published: November 2022

Listeria monocytogenes is a pathogenic Listeria species, especially for high-risk groups and it that can be transmitted through contaminated food. Goat milk produced by traditional milking process and storage has a high risk of contamination. The aim of this study was to identify the presence of L. monocytogenes in fresh goat milk in Puworejo regency, Central Java. This study used 60 samples of raw goat milk that were obtained from seven farms by disease detection sampling method. All of the used method in this research refer to Indonesian National Standard (SNI) ISO 11290-1: 2012 about Microbiology of food and feed for detection and enumeration of Listeria monocytogenes. A total of 60 samples of raw goat milk that used in this study were not contaminatedwith L. monocytogenes. Based on the results of this study, it can be concluded that all the samples of raw goat milk were free from L. monocytogenes and have fulfilled the Indonesian National Standard (SNI) ISO No. 7388: 2009 about Limit of Microbial Contamination in Food.
Tingkat Kejadian Escherichia coli Penghasil Extended Spectrum Β-Lactamase yang Diisolasi dari Feses Broiler di Kota Bogor
Authors: Masruroh Cholilia Abadiatul , Sudarwanto Mirnawati Bachrum , Latif Hadri 
Published: November 2022

The use of antibiotics in food-producing animals may encourage the occurence of bacterial resistance named Escherichia coli that produces Extended Spectrum β-lactamase (ESBL). Antibiotical resistance is an important issue in the animal health and human health. This study focused on the presence of ESBL-producing E.coli in chicken feces. The number of sample feces was 100. E. coli isolates were obtained from broiler chicken feces in Bogor. Isolates obtained were identified using API 20E kit. Confirmation of ESBL in this study used Double disc method using antibiotical disc namely cefpodoksim, ceftazidime and cefotaxime. The existence ofESBL-producing E. coli which isolated from the feces of broiler chickens in the city of Bogor is 25% (4/16).