bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oocyte Casein kinase 1α deletion causes defects in primordial follicle formation and oocyte loss by impairing oocyte meiosis and enhancing autophagy in developing mouse ovary
Authors: Zhang Di , Jiang Ying , Luo Xuan , liu Hui , Zhou Yewen , Cui Sheng 
Published: June 2022

Abstract
Casein kinase1α is a member of CK1 family, which is ubiquitously expressed and plays multiple functions, including its potential roles in regulating cell division. But the functions of CK1α in mammalian oogenesis and folliculogenesis remain elusive. In this study, we firstly assayed the cell type of CK1α expression in the developing mouse ovary and confirmed that CK1α highly expressed in oocyte. The oocyte-specific CK1α knockout (cKO) mouse model was then established by crossing Ddx4-Cre mice with Csnk1a1-floxp mice, and the effects of CK1α deletion on oogenesis and folliculogenesis were identified. The results showed that oocyte CK1α deletion impaired the progression of oocyte meiosis and primordial follicle formation during meiotic prophase I, which subsequently causes oocyte loss and mouse infertility. Further, the in vivo CK1α deletion and in vitro CK1α activity inhibition resulted in the defects of DNA double-strand break (DSB) repair, whereas the apoptosis and autophagy were enhanced in the developing ovary. These may contribute to the oocyte loss and infertility in cKO mouse. It is thus concluded that CK1α is an essential factor for mouse oogenesis and folliculogenesis by involving in regulating the processes of oocyte meiosis and DNA DSB repair during meiotic prophase I of oocytes, although the related signaling pathway and the molecular mechanism need to be elucidated further.
Multi-objective Evolutionary Algorithm for the Design of Resilient OTN over DWDM Networks
Authors: Silva Jose C. , Xavier Andre V. S. , Martins-Filho Joaquim F. , Bastos-Filho Carmelo J. A. , Chaves Daniel A. R. , Oliveira Arysson S. , Almeida Raul C. , Araujo Danilo R. B. , Martins Jose A. 
Published: June 2022

Abstract
The high-quality telecommunications services demand has grown considerably due to the increase in the number of applications on the Internet. Optical networks are the most suitable technology to supply the high transmission rates required. With the expansion of the optical communications market, businesses related to this industry started to attract more innovation investments in this area. Optical Transport Network (OTN) arrived in the communications market bringing economic and operational benefits of virtualization to the optical network. This technology works as a superior layer to the DWDM (Dense Wavelength Division Multiplexing) network, allowing more efficient resource use. OTN switching decouples customers from DWDM line interfaces, ensuring that DWDM links work as efficiently as possible, thus avoiding wasted transmission bandwidth. This concept is carried out on a network of OTN switches, allowing traffic to be aggregated at intermediate nodes and directed to routes that are being underutilized. Planning OTN networks over DWDM is a complex problem, as it involves a whole new equipment structure and logical architecture. This problem has arisen due to academia and industry’s interest in developing planning heuristics that reduce the cost of projects. This paper proposes planning OTN networks over DWDM to minimize the cost with line interfaces while meeting resilience requirements. This paper proposes to use a multi-objective evolutionary algorithm to seek a solution that optimizes the project considering conflicting decision variables, the number of used OTN interfaces , and the restoration failure rate. The experiments carried out in this work showed that the proposed solution, when evaluated in several scenarios, obtained better results concerning the number of interfaces allocated compared with previous heuristic algorithms developed with the same objective.
The incidence of bracing treatment on static and dynamic baropodometric parameters in adolescent idiopathic scoliosis
Authors: Pavone Vito , Caldaci Alessia , Mangano Giulia , Maria Fabrizio Di , Panvini Flora Maria Chiara , Sapienza Marco , Vescio Andrea , Roggio Federico , Musumeci Giuseppe , Testa Gianluca 
Published: June 2022

Abstract
BackgroundPostural balance is an important but not well-studied concept in the treatment of adolescent scoliosis.ObjectivesThe aim of this study was to assess whether conservative treatment with Sforzesco bracing induced negative perturbations on postural stability, as related to static, postural, and dynamic baropodometric indicators.MethodsFrom November 2020 to October 2021, 12 subjects (12 females, aged 11 – 16) with moderate AIS, were selected among a group of 97 patients. Inclusion criteria were: 1) confirmed diagnosis of moderate AIS (Cobb angle of 21° to 35° for the primary curve); 2) thoracic or thoracolumbar primary curve; 3) skeletal immaturity with growth cartilage visible on pretreatment radiographs (Risser < 5); 4) chronological age between 11 and 16 years; and 5) Sforzesco bracing treatment. All patients underwent a physical examination and radiological measurements with anteroposterior and lateral scans. Static, postural, and dynamic assessments were performed twice by barefoot patients, with and without Sforzesco bracing. ResultsComparison between demographic, anthropometric, and clinical data considered relevant for the homogeneity of the sample, highlighted the absence of statistically significant differences between patients. We evaluated the point of maximum pressure with and without bracing and found no statistically significant differences (p value = 0.22).In the postural measurements, the latero-lateral oscillations, antero-posterior oscillations, and the average speed of oscillations were evaluated, comparing measurements with and without bracing. There were no statistically significant differences, except for the mean rate of oscillation, which was slightly increased in the recordings with a brace compared to those without a brace, p value = 0.045. The CPEI was also evaluated in both situations, although no statistically significant differences either with and without bracing (p > 0.05) were found.ConclusionsIn this study, we evaluated the effects of the Sforzesco brace on postural balance in a sample of adolescents with idiopathic scoliosis, to assess whether conservative treatment would lead to adverse disturbances in postural stability. Our findings show no statistically significant differences (p > 0.05) in static, postural, and dynamic baropodometric indicators.
Plasma calprotectin as an indicator of need of transfer to intensive care in patients with suspected sepsis at the emergency department
Authors: Parke Åsa , Unge Christian , Yu David , Sundén-Cullberg Jonas , Strålin Kristoffer 
Published: June 2022

Abstract
Background: Deciding whether to transfer patients with sepsis from the emergency department (ED) to intensive care units (ICUs) is challenging. We hypothesised that the new biomarker plasma calprotectin could be used to aid the selection of patients for intensive care transfer, since it has been shown to be a promising tool for the determination of sepsis severity in critical care.Methods: This prospective study was performed on consecutive sepsis alert patients in the ED of Karolinska University Hospital Huddinge. The sepsis alert mandates clinical assessment and decisions regarding treatment, disposition, and level of care by physicians from the ED, the Department of Infectious Diseases, and the ICU. Blood sample analysis for C-reactive protein, procalcitonin, neutrophils, and lymphocytes was routinely performed. P-calprotectin was analysed from frozen plasma samples, using a specific turbidimetric assay.Results: During the study period, the sepsis alert was triggered in 367 patients. Among 335 patients who were considered to have an infection, 66 patients (20%) were immediately transferred to the ICU or high-dependency unit (HDU), and 269 patients (80%) were transferred to ordinary wards. Median p-calprotectin for all patients with infection was 2.2 mg/L (IQR 1.2–3.9 mg/L). Median P-calprotectin was 3.3 (IQR 1.6–5.2) and 2.1 (IQR 1.1–3.5) for patients transferred to ICU/HDU and ward units, respectively (p = 0.0001). Receiver operating characteristic curve analysis for transfer to the ICU/HDU showed superiority for p-calprotectin compared with procalcitonin and neutrophil-lymphocyte ratio, regarding both all sepsis alert cases and the patients with infection (p < 0.001 for all comparisons). The best p-calprotectin cut-off, 4.0 mg/L, showed a sensitivity of 42% and specificity of 83% for transfer to the ICU/HDU among patients with infection.Conclusions: In sepsis alert patients, p-calprotectin was significantly elevated in patients who were subject to immediate ICU/HDU transfer after assessment by a multidisciplinary team. P-calprotectin was superior to traditional biomarkers in predicting the need for transfer to the ICU/HDU.
Global regulatory factor AaLaeA upregulates the production of antitumor substances in endophytic Alternaria alstroemeria
Authors: Yin Xuemin , Han Long , Zheng Wen , Cai Lu , Qin Min , He Zhangjiang , Kang Jichuan 
Published: June 2022

Abstract
The global regulatory factor LaeA has been shown to be involved in the biosynthesis of secondary metabolites in various fungi. In a previous work, we isolated an endophytic fungus from Artemisia annua, and its extract had a significant inhibitory effect on the A549 cancer cell line. Phylogenetic analysis based on ITS sequences further identified the strain as Alternaria alstroemeria. Overexpression of the global regulatory factor AalaeA gene resulted in significantly increased antitumor activity of this strain’s extract. The 3 - (4, 5- dimethylthiazol − 2 - yl) -2, 5 - diphenyltetrazolium bromide (MTT) assay results showed that the inhibition rate of the AalaeAOE29 mutant extract on A549 cancer cells was significantly higher than that of the WT extract, as the IC50 decreased from 195.0 µg/mL to 107.4 µg/mL, and the total apoptosis rate was enhanced. Overexpression of the AalaeA gene significantly increased the contents of myricetin, geraniol, ergosterol and 18 other antitumor compounds as determined by metabolomic analysis. Transcriptomic analysis revealed significant changes in 95 genes in the mutant strain, including polyketide synthases (PKSs), nonribosomal peptide synthases (NRPSs), cytochrome P450s, glycosyltransferases (GTs), acetyl-CoA acetyltransferases and others. These results suggested that AaLaeA mediated the antitumor activity of the metabolites in A. alstroemeria by regulating multiple metabolic pathways.
Green space accessibility helps buffer declined mental health during the COVID-19 pandemic
Authors: Lee Kwan Ok , Mai Ke , Park Souneil 
Published: June 2022

Abstract
Accumulating evidence has highlighted a negative effect of COVID-19 pandemic on public mental health. By using data from 2 million mobile phone users within London over the period of January 2019–December 2020, as well as the multi-wave data from the UK Household Longitudinal Survey (UKHLS), we examined green space accessibility as a potential remedy for such an effect. We found that, after the COVID-19 outbreak and during lockdowns, individuals who live close to the green spaces (i.e., within 800 meters from the nearest green space) were more likely to pay visits to those spaces, and these individuals also experienced a much less mental distress than those who live farther away from green spaces. Our findings provide suggestive evidence that accessibility to green spaces is important to the population’s mental health, especially when their mobility is restricted. Enhancing green space accessibility for more residential neighbourhoods should thus be important to city planners and policymakers as they help citizens become more resilient to a similar future pandemic.
Association of estimated glomerular filtration rate and all-cause mortality in acute pancreatitis: a retrospective analysis
Authors: Gong Fang , Zhou Quan , Gui Chunmei , Huang Shaohua 
Published: June 2022

Abstract
Background: Our primary objective was to explore the association between estimated glomerular filtration rate (eGFR) and all-cause mortality in acute pancreatitis (AP) admission to intensive care units .Methods: This study is a retrospective cohort analysis based on the Medical Information Mart for Intensive Care III database. The eGFR was calculated based on Chronic Kidney Disease Epidemiology Collaboration equation. Cox models with restricted cubic spline functions were used to evaluated the association of eGFR with all-cause mortality.Results:The mean eGFR was 65.93±38.56 ml/min/1.73 m2 in 493 eligible patients. 28-day mortality was 11.97% (59/ 493) , which decreased by 15% with every 10 ml/min/1.73 m2 increase in eGFR. The adjusted hazard ratio (95% confidence interval) was 0.85 (0.76-0.96). A non-linear association was proved between eGFR and all-cause mortality. When eGFR < 57 ml/min/1.73 m2, there was a negative correlation between eGFR and 28-day mortality, hazard ratio (95% CI) was 0.97 (0.95, 0.99). The eGFR was also negatively correlated with in-hospital and in-ICU mortality. Subgroup analysis confirmed that the association between eGFR and 28-day mortality in different characteristics was stable. Conclusions: The eGFR was negatively correlated with all-cause mortality in AP when eGFR is less than the threshold inflection point.
Geographic information system-based comparison of the accessibility of primary public dental care for children in Saudi Arabia
Authors: Aqeeli Amal , Alsharif Alla T. , Kruger Estie , Tennant Marc 
Published: June 2022

Abstract
Objective: To examine the geographic distribution and accessibility of primary public dental services (PPDS) for the child population in Al Madinah in comparison with that in Jeddah in Saudi Arabia (SA). Methods: A cross-sectional study design was used to conduct this descriptive study in two of the main cities in the western region of SA: Al Madinah and Jeddah. PPDS locations were mapped using geographic information system (GIS) and associated with child population data of 0- to 17-year-olds, within buffers of 1,2.5, and 5 km around each PPDS location. Results: An uneven distribution of dental services was found, with services concentrated in certain districts (with high density populations) in both cities and other districts with far fewer or no dental services. The proportion of children who lived within 1 km of a dental service was 53% in Al Madinah and 22 % in Jeddah. Most children lived within 5 km of public health centres in both cities. Conclusion: In both cities, acceptable access to dental services for children was found on the basis of the data and variables analysed in this study. However, further analysis is recommended.
Synthesis of Orange-Red Emissive Au-SG and AuAg-SG Nanoclusters and Their Turn-OFF vs. Turn-ON Metal Ion Sensing
Authors: Bowmik Sagar , Paria Shashikana , Tater Ishika , Maity Prasenjit 
Published: June 2022

Abstract
Synthesis of luminescent metal cluster for selective sensing of specific analyte with detail mechanistic understanding is very important for real world applications as well as for developing new emissive materials. In the present work, we have synthesized L-glutathione stabilized gold (Au-SG) and gold-silver bimetallic (AuAg-SG) clusters under identical experimental conditions with orange red emissive characteristics for both. Detail photo physical analysis reveals that both clusters are phosphorescent in nature with moderate quantum yield of 7% and 19% for Au-SG and AuAg-SG respectively and their excited state lifetime values are in the range of 1–2 µs. While Au-SG cluster showed luminescence quenching response (turn-off) in presence of Fe3+ and Hg2+ ions, AuAg-SG cluster showed turn-off response for Cu2+, Fe3+ and Hg2+, but luminescent enhancement (turn-on) response for Cd2+ ions. The highest detection limit obtained for Cu2+ ion by AuAg-SG cluster is 20 nM while for Cd2+ ion it is 75 nM. From TCSPC and DLS measurements we postulated that except Cd2+, all other metal ions cause aggregation of clusters through ligation with SG ligands while Cd2+ ion does not induce any cluster aggregation but binds to cluster surface atoms. The near constant life time values of both clusters during gradual addition of respective metal ions confirms static quenching/enhancement process through formation of stable ground state adducts.
Nutritional Status and Feeding Behavior Problems of Turkish Children with Special Learning Disabilities
Authors: İnan Cansu Memiç , Özçelik Ayşe Özfer 
Published: June 2022

Abstract
Background: The most common feeding behavior problems in childhood are refusal to eat, eating too little, choosing food, and inappropriate behavior at mealtimes, and they are more common in children with neurodevelopmental disorders than in children with normal development. Specific Learning Disability (SLD), one of the neurodevelopmental disorders, is defined as educational skills being below what is expected according to chronological age and intelligence level. In this cross-sectional study aims to determine the nutritional behavior problems and nutritional status of children with specific learning difficulties.Method: Sociodemographic informations, anthropometric measurements and food consumption records of 76 children (38 boys and 38 girls) diagnosed with SLD were obtained by face-to-face interviews and applying a questionnaire. The Behavioral Pediatrics Feeding Assessment Scale was used to determine the feeding behavior problems of children.Results: The mean age of the children was 9.67±0.19 years. According to the BMI-Z score classification, 2.6% of the children were underweight, 17.1% were overweight and 14.5% were obese. Feeding behavior problems were found in 39.5% of the children. The dietary protein intake of children with feeding behavior problems was found to be significantly lower than those without (p<0.05). A negative and significant correlation was found between feeding behavior problems and body weight (r=-0.406), BMI (r=-0.423), TMI (r=-0.404), MUAC (r=-0.540), TSFT (r=-0.395) and waist circumference (r=-0.337) (p<0.05). Conclusions: In conclusion, it was determined that feeding behavior problems are common in children diagnosed with SLD. Childhood eating behavior problems are likely to persist into young adulthood and may have adverse effects on overall health. Therefore, the nutritional status of children with SLD should be evaluated with appropriate screening tests.
Anthropogenic signature of global agricultural soil phosphorus
Authors: Demay Joséphine , Ringeval Bruno , Pellerin Sylvain , Nesme Thomas 
Published: June 2022

Abstract
The global phosphorus (P) cycle has been dramatically altered by human activities through the use of mineral P fertilizers, often referred to anthropogenic P. The application of mineral P fertilizers on agricultural soils has driven the planet beyond its safe operating space but the extent to which the global P cycle relies on anthropogenic P has never been quantified. To fill this gap, we developed a model that simulates, at the country scale, the evolution of agricultural soil available P by distinguishing anthropogenic vs. natural P pools, and by accounting for farming practices, crop-livestock recycling loop, and agricultural trade, over the 1950-2017 period. At the global scale we found that the anthropogenic signature of soil available P was 45% ± 8% in 2017. The national anthropogenic signatures varied according to the cumulative mineral P fertilizer use as well as to the soil P availability in 1950. Despite having different historical trajectories, Western Europe, North America and Asia displayed similar reliance on anthropogenic P, close to 60% in 2017. Conversely, African soil anthropogenic signature remained around 30%. Trade did not modify the simulated signatures. Overall, our results unravel the strong reliance of our soil fertility and food production systems on anthropogenic P resources.
Fabrication of amine cross-linked magnetic biopolymer adsorbent for the removal of a cationic dye and its isotherm, kinetics and thermodynamic study
Authors: Rhaman Md. Masudur , Islam Md. Din , Karim Md. Rezaul , Ahmed Yunus , Hyder M. K. Mohammad Ziaul 
Published: June 2022

Abstract
A novel amine cross-linked magnetic biopolymer based on jute stick powder (AMB-JSP) was fabricated by in situ chemical co-precipitation method. The adsorbent AMB-JSP was applied to remove methylene blue (MeB) from aqueous solution. The adsorption efficiency of fresh jute sticks powder (JSP) and magnetic jute stick powder (MB-JSP) were also taken in consideration to build up a comparison study with the novel AMB-JSP adsorbent. The maximum MeB removals with AMB-JSP were observed as 85.71% at pH 8.0. Freundlich isotherm was best fitted for AMB-JSP while the Langmuir adsorption isotherm was suited for JSP and MB-JSP. The maximum MeB uptake for JSP, MB-JSP and AMB-JSP were found to be 157.23, 169.45 and 181.49 mgg− 1, respectively. The agitation times to reach equilibrium were found to be 160, 120 and 40 min for JSP, MB-JSP and AMB-JSP, respectively at temperature 303.15 K. The interparticle diffusion kinetics showed the best result for JSP, MB-JSP and AMB-JSP. In addition thermodynamic study indicated that the adsorption procedure was endothermic in nature and thus spontaneous. This study reveals that AMB-JSP could be applied as a potential magnetic bioadsorbent for the removal of MeB dye from an aqueous solution.
Filon-Clenshaw-Curtis Quadrature with Automatic Tone Removal
Authors: Milovich David 
Published: June 2022

Abstract
Note: Please see pdf for full abstract with equations. We present an adaptive method of computing finite Fourier integrals (eq) for smooth f and smooth nonzero g, intended for the case where g is highly and irregularly oscillatory, but f, |g|, and (arg(g))' are not highly oscillatory. Our method easily extends to real-valued integrals (eq) where h is smooth, with the intention that h is not highly oscillatory but cos h is. We do not require any special information about f or g, just the ability to evaluate f, g, and g' at arbitrary points. Our basic step per subinterval is to integrate (eq) where m is the slope of arg(g) at the subinterval center and h(x) is a Chebyshev polynomial interpolation of f(x)g(x)e-imx. Thus, a tone is factored out to improve Chebyshev interpolation accuracy. We also investigate a second-order extension in which a chirp is factored out. An implementation of this paper's algorithms in the Julia programming language is publicly available.