bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conspicuous by Their Presence: Brutus, Cassius, and Cato the Younger in the Writings of Tacitus
Authors: Strunk Thomas E. 
Published: July 2022

Abstract
Tacitus is an unlikely source for our study of Brutus, Cassius, and Cato, as they stand outside the chronological framework of Tacitus’ writings; nonetheless, they do appear a number of times throughout his works, and Tacitus portrays them with nuance and significance. As Brutus, Cassius, and Cato are rarely the precise focus for Tacitus, they are often referred to obliquely or in dialogue or speeches typically regarding treason and liberty. This paper will explore Tacitus’ depiction of Brutus, Cassius, and Cato in his major and minor works, including the oblique references to Cato, Brutus as an orator and writer, Brutus and Cassius as commanders in civil war, and lastly their memory as it pertains to liberty and treason. Tacitus’ contribution to our understanding of Brutus, Cassius, and Cato comes from both his own use of them as markers of political memory and liberty and his examination of how others used Brutus, Cassius, and Cato to make arguments for political liberty or for the basis of accusations of treason.
Patient Compliance With Surveillance of Thyroid Nodules Classified as Atypia of Undetermined Significance
Authors: Walters Benjamin K. , Garrett Samuel L. , Aden James K. , Newberry Travis R. , Mckinlay Alex J. 
Published: July 2022

Objective: To determine whether thyroid nodule surveillance compliance is influenced by patient demographics or plan type. Study Design: Retrospective case series from 2010 to 2018. Setting: United States Military Health System. Methods: There were 481 patients with a thyroid nodule fine-needle aspiration classified as atypia of undetermined significance for whom treatment and follow-up information were available. Demographic information and surveillance plan type were extracted from the medical record and statistical analysis was performed to determine whether these characteristics influenced compliance rates. Results: A total of 289 nodules were surveilled and 192 diagnostic lobectomies were performed. An initial surveillance plan was documented in 93% (268/289) and 86% (231/268) complied. The most common plans were repeat biopsy in 78% (210/268) or ultrasound in 20% (53/268). A second plan was documented in 88% (204/231) of those who complied with the first. The most common second plans were ultrasound in 87% (178/204) or repeat biopsy in 8% (17/204). Compliance with the second plan was 64% (130/204), significantly lower than with the first (OR 3.6, 95% CI: [2.3, 5.6], P < .0001). Only 45% (130/289) were surveilled twice. Age and gender did not significantly affect compliance rates. Compliance with primary care ultrasound surveillance was 40% (21/52), significantly lower than with a specialist (77% [137/179]; OR 4.8, 95% CI: [2.5, 9.3, P < .0001). Conclusion: Compliance with surveillance of thyroid nodules classified as atypia of undetermined significance was poor in this military cohort. Ultrasound surveillance by a specialist may be more reliable than with primary care.
Depression and antidepressant treatment in the development of hypertensive disorders of pregnancy: Results from a prospective cohort study
Authors: Galbally Megan , Watson Stuart J , Spigset Olav 
Published: July 2022

Background: Hypertensive disorders of pregnancy are associated with longer term cardiovascular risk. Understanding if depression or antidepressant use in pregnancy is associated with HDP is important in identifying those potentially vulnerable to poorer health in later life. This study examines if depression and antidepressants are associated with HDP. Methods: In all, 815 pregnant women were recruited within an Australian pregnancy cohort study at less than 20 weeks of pregnancy, all undertook the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, and were assigned to four groups for this paper: those with unmedicated depression meeting criteria for current depression ( n = 97), those taking selective serotonin reuptake inhibitors in early pregnancy ( n = 101), those taking serotonin and noradrenaline reuptake inhibitors in early pregnancy ( n = 31), and those without depression or taking antidepressant medication (control; n = 586). Women were then assessed again following birth. Hypertensive disorders of pregnancy were diagnosed according to the Society of Obstetric Medicine in Australia and New Zealand Guidelines. Results: Use of serotonin and noradrenaline reuptake inhibitors (SNRIs) (adjusted risk ratio = 9.10, 95% confidence interval = [3.82, 21.67]) and unmedicated depression (adjusted risk ratio = 3.11, 95% confidence interval = [1.32, 7.35]) were independently associated with significantly higher risk for developing hypertensive disorders of pregnancy compared to controls. Selective serotonin reuptake inhibitors (SSRIs) use did not confer any increased risk. Higher doses of SNRIs, but not selective serotonin reuptake inhibitors, were associated with significantly higher risk for developing HDP (adjusted risk ratio = 4.83, 95% confidence interval = [1.50, 15.58]). Conclusions: Our findings suggest that those with depression in pregnancy and/or on an serotonin and noradrenaline reuptake inhibitor should have closer surveillance for the development of hypertensive disorders of pregnancy. These findings support treatment of depression in pregnancy, however, also the consideration of class of antidepressant.
Prevalence and determinants of mental health related to climate change in Australia
Authors: Patrick Rebecca , Snell Tristan , Gunasiri Hasini , Garad Rhonda , Meadows Graham , Enticott Joanne 
Published: July 2022

Aims: The climate emergency will likely prove this century’s greatest threat to public health within which mental health effects need consideration. While studies consistently show the majority of Australians are very concerned about the impacts of climate change, there is limited evidence from nation-wide research linking climate change with mental health burden in sub-populations. This study aimed to understand the impact of climate change on mental health in the Australian population and identify populations who are most at risk of climate-related mental health burden. Methods: A nation-wide Australian survey conducted between August and November 2020 of adults was approximately representative across sex, age, location, state and area disadvantage. Two-stage recruitment involved unrestricted self-selected community sample through mainstream and social media ( N = 4428) and purposeful sampling using an online panel ( N = 1055). Results: Most Australians report having a direct experience of a climate change–related event. Young people are experiencing significant rates of eco-anxiety. One in four people with direct experience of a climate change–related event met post-traumatic stress disorder screening criteria. People who have not had a direct experience are showing symptoms of pre-trauma, particularly in younger age groups and women. There were 9.37% (503/5370) of respondents with responses indicating significant eco-anxiety, 15.68% (370/2359) with pre-traumatic stress and 25.60% (727/2840) with post-traumatic stress disorder. Multivariable regressions confirmed that younger people are more affected by eco-anxiety and post-traumatic stress disorder (pre- or post-trauma); women are more affected by post-traumatic stress disorder (pre- or post-trauma) and those from more disadvantaged regions are more affected by eco-anxiety. Conclusion: Australia is facing a potential mental health crisis. Individuals with and without direct experience of climate change are reporting significant mental health impacts, with younger age groups being disproportionately affected. There are key roles for clinicians and other health professionals in responding to and preventing climate-related mental health burden.
Racialized Employment Outcomes During Reentry: A Test of Competing Explanations
Authors: Liu Lin 
Published: July 2022

Although much literature has examined the racial gap in employment, relatively fewer efforts have been devoted to examining racialized employment outcomes in the context of reentry. The factors associated with the racial gap in post-release employment are largely unknown. Even less is known whether a disadvantage factor exerts disparate effects on minority and White returning citizens. Using longitudinal data documenting returning citizens’ social capital, health, neighborhood conditions, parole supervision, and employment outcomes over 15 months after release, this study extends prior studies by testing three competing explanations of the racial gap in post-release employment. Findings suggest that structural disadvantages and criminal history cannot fully explain the lower employment rates of Black returning citizens. Furthermore, this study did not find a significant race-specific effect of social capital on employment outcomes. Implications for reentry programing and interventions are discussed.
Association of Laryngopharyngeal Reflux Disease and Refractory Chronic Rhinosinusitis
Authors: Shen Xueliang , Zhang Zhijuan , Wu Yating , Li Yongchun , Li Huijuan , He Jiao , Shi Qiangyou , Feng Ningyu , Wen Wulin , Ma Ruixia 
Published: July 2022

Objective The current study was conducted to explore the association between laryngopharyngeal reflux disease (LPRD) and refractory chronic rhinosinusitis (RCRS), and to reveal the potential role of LPRD in the development of RCRS. Methods A total of 104 patients diagnosed as chronic rhinosinusitis (CRS) and hospitalized, as well as 50 healthy participants were enrolled into this study. Among patients enrolled, 53 were RCRS and 51 were CRS. All participants were assessed with reflux symptom index (RSI) and reflux finding score (RFS). Patients with RSI >13 and/or RFS >7 were diagnosed as LPRD. In addition, pepsin in the nasal secretions from the middle meatus tract complex at fasting in the morning was analyzed using ELISA. Patients with pepsin concentration of >75 ng/ml was considered as positive, and confirmed as LPRD. Results There was no significant difference in age, sex, height, and weight among RCRS, CRS, and control groups. The positive rates of RSI and RFS scores were 39.6% in the RCRS and 52.9% in the CRS, respectively, which were significantly higher than that of the control group (14.0%, P < 0.05), respectively. Significantly higher positive rate of pepsin assay was also observed for RCRS(43.4%) and CRS(64.7%) when compared with the control group (18.0%, P < 0.05). The positive rate of pepsin assay was strongly associated with the positive rate of RSI or RFS ( P < 0.001). Conclusion The present findings have important implications that RSI and RFS score was highly associated with pepsin assay result in the patients with RCRS or CRS. We confirmed the importance of RSI and RFS scoring system as well as pepsin test, which may offer insight for clinical screening for LPRD among CRS patients.
Exploring the Agency of Black LGBTQ+ Youth in Schools and in NYC’s Ballroom Culture
Authors: Reid Shamari 
Published: July 2022

Background/Context: In recent years, youth agency has become more prevalent in education research, with many scholars agreeing that youth agency is highly contextual, reliant on multiple forces, and inextricably connected to social identity. However, relatively few studies have explored the agency of Black LGBTQ+ youth and how these youth understand their own agency. This fact connects to the reality that although there is a growing body of research around the educational experiences of LGBTQ+ youth of color, it is often centered on their victimhood and rarely explores how they practice agency to respond to the challenges they face. Purpose/Objective/Research Question/Focus of Study: Recognizing the importance of context and social identity with regard to youth agency, this study extends the literature on youth agency and LGBTQ+ youth of color by exploring the following research question: How do eight Black LGBTQ+ youth who are active members in New York City’s ballroom culture make sense of their agency in school and in out-of-school ballroom spaces? Data Collection and Analysis: Following Seidman’s (2013) interview process, three separate interviews were conducted with all eight youth. In addition, all eight youth participated in two focus groups. The data analysis was informed by a queer of color critique theoretical framework and focused on specific occurrences in the data in which the young people articulated understandings of their agentive practices that worked toward responding to, resisting, or subverting racial and anti-LGBTQ+ marginalization across schooling and ballroom contexts. Findings: Findings indicate that the youth regarded school as a confining space in which they were fearful of anti-LGBTQ+ rejection and abuse. Thus, they used their agency to suppress their LGBTQ+ identities in order to minimize their experiences with discrimination. Suppressing their identities resulted in the youth feeling disconnected from school and isolated, and increased their risk for depression and anxiety. Contrastingly, the youth understood ballroom as a liberatory space in which they felt able to confidently explore and express their LGBTQ+ identities and create alternatives for themselves outside socially constructed expectations of their identities. Conclusions/Recommendations: Results suggest that Black LGBTQ+ youth are always practicing agency, albeit to work toward different ends, such as occulting or exploring their LGBTQ+ identities. Findings suggest that schools can learn from ballroom spaces how to better invite Black LGBTQ+ youth into schools in humane and educative ways, encourage their agentive imaginations within education spaces, and promote liberatory school environments that recognize and embrace these youth’s racial, gender, and sexual identities.
A low-cost, flexible extruder for liposomes synthesis and application for Murrayafoline A delivery for cancer treatment
Authors: Pham Dan The , Nguyen Linh Phuong , Pham Quynh Thi Huong , Pham Chi Khanh , Pham Dung Thuy Nguyen , Viet Nguyen Thanh , Nguyen Hong Van Thi , Tran Toan Quoc , Nguyen Duong Thanh 
Published: July 2022

Liposomal encapsulation is a drug delivery strategy with many advantages, such as improved bioavailability, ability to carry large drug loads, as well as controllability and specificity towards various targeted diseased tissues. Currently, most preparation techniques require an additional extrusion or filtering step to obtain monodisperse liposomes with the size of less than 100 nm. In this study, a compact liposome extruder was designed at a cost of $4.00 and used to synthesize liposome suspensions with defined particle size and high homogeneity for Murrayafoline A (Mu-A) loading and release. The synthesized MuA-loaded liposomes displayed a biphasic drug release and remained stable under the storage condition of 4°C. They also significantly reduced the viability of HepG2 cells in the cancer spheroids by 25%. The low-cost, flexible liposome extruder would allow the researchers to study liposomes and their applications in a cost-effective manner.
Associations between self-test and pre- or post-exposure prophylaxis of HIV among men who have sex with men in China
Authors: Wang Xiaofang , Hu Xiaosong , Liu Zhongfu , Hui Hongtao 
Published: July 2022

Background This study aims to assess HIV self-testing (HIVST), pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) uptake and associations of three HIV prevention strategies among men who have sex with men (MSM) in China. Methods This study included two stages, baseline and follow-up, and was conducted in Harbin, the capital city of Heilongjiang province in North China. MSM were recruited online and by peer-referral. Data contained an online questionnaire and sampling blood for HIV tests. The research group generated a QR code linking to the survey, and participants were asked to scan this QR code with a cellphone to fill out the questionnaire. MSM at the baseline were imparted knowledge of PrEP, PEP and condom use. Results Between January 2018 and March 2019, the research team enrolled 773 MSM for baseline analysis, and 699 were HIV negative at baseline. For follow-up, 62% (430/699) participants were retained. At baseline, 11.6% (50/430) of the participants was aware of PrEP and 40.9% (176/430) of PEP; 0.7% (3/430) had ever taken PrEP and 3.3% (14/430) had taken PEP. At follow-up, 77.7% (334/430) reported awareness of PrEP and 54.0% (232/430) for PEP; Only 2.6% (11/430) initiated PrEP uptake and 3.0% (13/430) for PEP. Additionally, at follow-up, only 21 participants newly conducted HIVST. Results showed that being willing to pay for PrEP and PEP uptake was associated with conducting HIVST, and initiations of two HIV prevention methods, PrEP and PEP uptake, were significantly associated with each other. Conclusions Knowledge dissemination increased participant awareness and acceptance of PrEP and PEP effectively. Uptake of HIVST, PrEP, and PEP were low and associated with each other. It is promising to achieve high uptake by promoting HIVST, PrEP and PEP as one prevention package.
Opinions of nurses regarding Euthanasia and Medically Assisted Suicide
Authors: Velasco Sanz Tamara Raquel , Cabrejas Casero Ana María , Rodríguez González Yolanda , Barbado Albaladejo José Antonio , Mower Hanlon Lydia Frances , Guerra Llamas María Isabel 
Published: July 2022

Background Safeguarding the right to die according to the principles of autonomy and freedom of each person has become more important in the last decade, therefore increasing regulation of Euthanasia and Medically Assisted Suicide (MAS). Aims To learn the opinions that the nurses of the autonomous region of Madrid have regarding Euthanasia and Medically Assisted Suicide. Research design Cross-sectional descriptive study. Participants and research context All registered nurses in Madrid. The study was done by means of a self-completed anonymous questionnaire. The variables studied were social-demographic, giving opinions about Euthanasia and MAS. Ethical considerations Each participant was assured maximum confidentiality and anonymity, ensuring the ethical principles set out in the Declaration of Helsinki, as well as in the Organic Law 3/2018, on Personal Data Protection and guarantee of digital rights. Findings A total of 489 nurses answered the questionnaire. In total, 75.7% of the nurses confirmed that Euthanasia should be regulated in Spain. 66.3% indicated that information on Euthanasia should be provided jointly by doctors and nurses, and 42.3% considered that it could be applied by both medical and nursing professionals. A total of 87.2% advocated the participation of nurses in health policy, influencing the drafting of the law. In the face of possible regulation, 35% would request Conscientious Objection, being closely related to their religious beliefs. Discussion Different authors point out that nurses’ perceptions and attitudes towards Euthanasia are conditioned by different factors, such as religion, gender, poor palliative care, legality and the patient's right to die. Conclusion Nurses are positioned in favour of the regulation and practice of Euthanasia and MAS, depending on their age, years of experience, training, model of care and especially religious beliefs.
Cabotegravir: The First Long-Acting Injectable for HIV Preexposure Prophylaxis
Authors: Durham Spencer H. , Milam Ashlee , Waer Dylan , Chahine Elias B. 
Published: July 2022

Objective Review the pharmacology, pharmacokinetics, efficacy, safety, and role of long-acting injectable cabotegravir (CAB-LA) in HIV preexposure prophylaxis (PrEP). Data Sources A literature search was performed using PubMed and Google Scholar (2012 to April 2022) with the search terms cabotegravir, preexposure prophylaxis, and PrEP. Other resources included abstracts presented at recent conferences, the manufacturer’s Web site, prescribing information, and review articles. Study Selection and Data Extraction All English-language articles of studies assessing the efficacy and safety of CAB-LA for PrEP were included. Data Synthesis CAB-LA is the first long-acting injectable therapy approved for HIV-1 PrEP in both men and women. It is a suspension given intramuscularly every other month. CAB-LA has been shown to be more effective than daily oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) in preventing HIV-1 infection among high-risk individuals. Two phase 3 trials were stopped early on the basis of superior efficacy of CAB-LA. The most common adverse effects were injection site reactions (ISRs), although they tended to decrease over time, and few participants in clinical trials discontinued use due to ISRs. Relevance to Patient Care and Clinical Practice CAB-LA may be particularly useful for individuals with known adherence problems to oral therapy, those with renal impairment, and those with decreased bone mineral density. However, CAB-LA is more expensive than generic TDF/FTC and may be associated with weight gain. Conclusions CAB-LA is the first long-acting injectable agent for HIV PrEP. It is more effective than oral TDF/FTC, is well-tolerated aside from ISRs, and has few clinically significant drug-drug interactions.
The Effects of Adding Semaglutide to High Daily Dose Insulin Regimens in Patients With Type 2 Diabetes
Authors: Meyer Jodi , Dreischmeier Emma , Lehmann Molly , Phelan Jessica 
Published: July 2022

Background: Escalating doses of insulin required with progression of type 2 diabetes may lead to weight gain. Weight loss associated with semaglutide may be beneficial. However, data on the use of semaglutide in patients requiring high daily doses of insulin are currently lacking. Objective: The purpose of this project was to evaluate the impact of semaglutide on total daily dose (TDD) of insulin when initiated in patients with type 2 diabetes mellitus (T2DM) on high daily doses of insulin. Secondary objectives assessed included changes in weight, body mass index (BMI), blood pressure, heart rate, and diabetes and blood pressure medications. Methods: This IRB exempt retrospective medical record review included patients with T2DM prescribed semaglutide and at least 100 units TDD of insulin between January 1, 2019, and December 31, 2019. Results: Of the 72 patients included, the TDD of insulin decreased from baseline to 6 months (183 ± 98 units and 143 ± 99 units, P < 0.001). Average A1c and body weight also decreased from baseline to 6 months (8.9% ± 1.3% and 7.6% ± 1.5%, P < 0.001 and 123.9 ± 23.5 kg and 118.9 ± 22.9 kg, P < 0.001, respectively). Limitations included a homogenous patient population and inability to control confounding factors. Conclusion and Relevance: Improvement in glycemic control occurred despite reductions in TDD of insulin. Improvements in A1c and body weight were clinically significant. This analysis adds to existing literature supporting the use of GLP-1 RAs in patients on high daily doses of insulin.