bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reshaping mental health care delivery during the COVID-19 pandemic: service response and telepsychiatry in a catchment area of 10 million people
Authors: D'Agostino Armando , Giordano Barbara , Cerveri Giancarlo , Tomassi Simona , Cibra Chiara , Poli Vanna , Sacchi Paola , Cipriani Andrea , Dell'Osso Bernardo , Brambilla Paolo , Gambini Orsola 
Published: August 2022

Abstract
BackgroundDetailed information on the effects of the COVID-19 pandemic on large public health systems is lacking. Here we describe the overall functioning of a regional network comprising 58 community mental health centres (CMHCs), which covers a catchment area of approximately 10 million people.MethodsWe employed a registry–based approach to summarize descriptive information on demographic and clinical data retrieved from all CMHCs over a two–year period, grouped according to the provinces of Lombardy in Italy. We then described the progression of all subtypes of remote vs. in-person consultations across provinces after the onset of the pandemic, and calculated remote/face–to–face service delivery ratios according to gender, age and main diagnosis.ResultsCompared to the previous year, the largest drop of outpatient contacts was recorded in provinces that were most affected by the early impact of the viral outbreak, peaking in March and May 2020 (-21.89% and -16.86% respectively). A progressive increase of telepsychiatry interventions was observed diffusely, reaching a peak of almost one every four consultations. Remote/face–to–face ratios were significantly higher in females across all age and diagnostic subgroups, in patients from lower age groups and with diagnoses of Eating and Obsessive–Compulsive disorders.ConclusionsOur study is the first to describe the impact of the pandemic on a large public mental health system. Future research on service uptake and cost–effectiveness of blended remote delivery should be tailored to service users of different age groups and clinical diagnoses to optimize organization of services.
“If this makes you happy”: a quanti-qualitative analysis of how adolescents have cared for their well-being during the COVID-19 syndemic
Authors: Pepe Alessandro , Farina Eleonora 
Published: August 2022

AbstractIn this study, we set out to investigate adolescents’ levels of perceived well-being and to map how they went about caring for their well-being during the COVID-19 syndemic. Participants were 229 Italian adolescent high school students (48.9% males, mean age = 16.64). The research design was based on an exploratory, parallel, mixed-method approach. A multi-method, student-centered, computer-assisted, semi-structured online interview was used as the data gathering tool, including both a standardized quantitative questionnaire on perceived well-being and an open-ended question about how adolescents were taking charge of their well-being during the COVID-19 health emergency. Main findings reveal general low levels of perceived well-being during the syndemic, especially in girls and in older adolescents. Higher levels of well-being are associated with more affiliative strategies (we-ness/togetherness) whereas low levels of well-being are linked with more individualistic strategies (I-ness/separatedness) in facing the health emergency. These findings identify access to social support as a strategy for coping with situational stress and raise reflection on the importance of balancing the need for physical distancing to protect from infection, and the need for social closeness to maintain good mental health.
Unpaid family responsibilities and absenteeism among health workers in primary healthcare centres in Enugu state, Nigeria: Does location of health facility matter?
Authors: Nwokolo Chukwudi , Onwujekwe Obinna , Obodoechi Divine Ndubuisi , McKee Martin , Angell Blake , Agwu Prince , Orjiakor Charles , Odii Aloysius , Hutchinson Eleanor , Balabanova Dina 
Published: August 2022

Abstract
Introduction: The high rate of absenteeism among health workers (especially those in primary healthcare) has become an issue of significant concern in Nigeria. It was estimated that 34% of staff are absent at any time, with substantial consequences for their ability to deliver safe and effective care. The available literature points to a diverse range of factors associated with absenteeism but one that has received less attention than others is the role of unpaid family responsibilities, which might be expected to vary with location of the facility. We examined the influence of unpaid family responsibilities on absenteeism among health workers and its interaction with urban and rural location. Method: The study was undertaken in Enugu state, southeast Nigeria using a cross sectional survey, which included 412 health workers that work in primary healthcare (PHC) facilities. Data were collected using an interviewer-administered questionnaire. The study used the revised Steers and Rhodes (1990) model of absenteeism, with binary logistic regression to examine the associations between absenteeism and unpaid family responsibilities capturing the interaction of location and unpaid family role. Results: Unpaid family responsibilities exhibit a positive but insignificant relationship with absenteeism. The same positive and insignificant relationship was found with rural location. However, when adjusted for location, unpaid family responsibilities significantly (p = 0.01) increased the probability of a health worker engaging in absenteeism by (26%). Also, health workers who live in the accommodation provided by facilities are significantly less likely to be absent. More so, health workers who perceive their workload to be manageable are significantly less likely to engage in absenteeism than those who perceive it to be occasionally too much but manageable and not manageable.Conclusion: There are few strategies that have been successful in addressing absenteeism especially in acknowledging causes that lie outside the health system. Unpaid family responsibilities and location of health facility independently increases absenteeism but their effects were not significant, however when the two are interacted, there is a significant positive effect which was traced to the positive association between rural location and absenteeism. These findings point to the potential to reduce absenteeism by finding new ways to support staff, such as offering flexibility to allow them to take care of family responsibilities and by better provision of health worker accommodation in rural areas by host communities.
Nonlinear dynamics of a three species prey-predator system incorporating fear effect and harvesting
Authors: Yadav Dinesh Kumar , Gupta Ravi Pratap , Kumar Arun 
Published: August 2022

Abstract
Fear of predators is a well-recognized phenomenon that results from predation in a natural food-chain or food-web ecosystem. Wang et al. (2016) published the first food-chain model that included the predator's fear effect on prey growth rate. The indirect impact of fear has been studied through its inclusion in several food web and food chain models in various ecological contexts. Some recent studies and field experiments show that predators affect their prey not only by direct capture; they also induce fear in prey species, which reduces their reproduction rate. The dynamics of a three-species prey-predator model are discussed, with the assumption that the logistic growth rate of prey is reduced as a result of both predators' fears, and the reproduction rate of intermediate consumers is affected by the top predator. We carry out the feasibility, existence of steady states, local stability analysis, and bifurcation analysis. Through numerical simulation, we show that the system stays chaotic at a low cost of fear, but an increase in the fear factor results in stability. We conclude that the chaotic dynamics of the system is controlled by fear effects, i.e., the whole prey-predator system is driven by the fear effect of predators.Mathematics Subject Classification (2020): 34D20, 34C23, 65P20
Antimicrobial Stewardship Intervention Before and During The COVID-19 Pandemic in the Acute Care Settings: A Systematic Review
Authors: Elshenawy Rasha Abdelsalam , Umaru Nkiruka , Alharbi Amal Bandar , Aslanpour Zoe 
Published: August 2022

Abstract
Introduction: Antibiotics are widely administered for various indications, leading to increased antimicrobial resistance (AMR) in acute care hospitals. Since the onset of the COVID-19 pandemic, Antimicrobial Stewardship (AMS) effective strategies should be used to maintain the rational use of antibiotics and decrease the threat of Antimicrobial Resistance (AMR). Aim: To investigate the AMS intervention Pre-pandemic (PP) and During-the-pandemic (DP) from the literature. Design and Setting: Systematic review of primary studies on AMS implementation in acute care settings. Methods: Relevant studies published between 2000 and March 2021 were obtained from Medline (via PubMed), Embase, OVID, CINAHL, International Pharmaceutical Abstracts, Psych Info, Scopus, Web of Science, Cochrane Library, OpenGrey, and Google Scholar, using a comprehensive list of search terms. Public Health England (PHE) toolkit was agreed as a gold standard for the AMS intervention strategies. The methodological quality of included studies was assessed using the Critical Appraisal Skills Programme (CASP) Programme. Results: There were 8763 articles retrieved from the databases. Out of these, 16 full-text articles met the inclusion criteria for the review. The AMS implementation was identified as AMS strategies, which include core and supplemental strategies and AMS measures PP and DP. Conclusion: This Systematic review summarises AMS implementation strategies and measures. Appropriate interventions appeared to be effective in maintaining the proper use of antibiotics and decreasing the AMR threat, especially DP. Further studies to investigate AMS implementation presented in this systematic review are imperative.
Intestinal Performance upon Broiler Chickens fed with or without Epidermal Growth Factor
Authors: Shan Chunqiao , Liu Qiuchen , Li Juan , Liu En , Tian Jing , Liu Yan , Yu Hongmin , Jiang Guotuo 
Published: August 2022

Abstract

Antibiotic abuse causes increasing occurance of antibiotic-resistance drug (ARD) species, further jeopardizes food safety. However, specific antibiotics, such as chlortetracycline, were traditionally used as growth promoting supplement. This dilemma remains to be unsolved until alternatives for antibiotics. We explore the potential of chEGF as an antibiotic substitute in this research. Here, we obtained and optimized a chEGF sequence, which was cloned to express and purify, and then fed broilers. The detection of alkaline protease, lipases and α-amylase by sandwich ELISA indirectly showed that EGF ameliorate digestive function of broilers with the regulation of enzyme activity in the normal diet, EGF supplement, and chlortetracycline supplement groups. Through histo-morphological methods, intestinal epithelial growth and induced EGFR expression, especially in duodenum, shows significant difference with comparison of each groups. We finally evaluate survival rate, ratio of feeding-weight, and european efficient index with pilot-scale chEGF in clinical study. The results shows chEGF can significantly increase economic efficiency index of broiler feeding. In conclusion, chEGF could be one kind of antibiotic alternatives in the broiler feeding industry by regulating the upper digestive system function and promoting nutrient uptake.
The IGF-independent role of IRS-2 in the secretion of MMP-9 enhances the growth of prostate carcinoma cell line PC3
Authors: Hakuno Fumihiko , Furuta Haruka , Sheng Yina , Kataoka Naoyuki , perks claire , Barker Rachel , Takahashi Shin-Ichiro 
Published: August 2022

Abstract
Insulin receptor substrate-2 (IRS-2), a substrate of the insulin-like growth factor (IGF)-I receptor, is highly expressed in the prostate cancer cell line, PC3s. We recently demonstrated that extracellular signal-regulated kinase (Erk1/2), a kinase downstream of IGF signaling, is activated in PC3 cells under serum starvation, and this activation can be inhibited by IRS-2 knockdown. Here, we found that the addition of an IGF-I neutralizing antibody to the culture medium inhibited the activation of Erk1/2. Further, suppression of Erk1/2 in IRS-2 knockdown cells was restored by the addition of PC3 serum-free conditioned medium. In contrast, IRS-2-silenced PC3 conditioned medium could not restore Erk1/2 activation, suggesting that IRS-2 promotes the secretion of proteins, yet to be identified that activate the IGF signaling pathway. Gelatin zymography analysis of conditioned medium showed that matrix metalloproteinase-9 (MMP-9) was secreted extracellularly in IRS-2 dependent manner when PC3s were cultured under serum starvation conditions. Finally, MMP-9 knockdown suppressed Erk1/2 activation, DNA synthesis, and migratory activity. Taken together with the positive correlation of IRS-2 levels with Gleason Grade in human prostate cancer tissues, this suggests that highly expressed IRS-2 activates IGF signaling by enabling the secretion of MMP-9, which is associated with hyperproliferation and malignancy of prostate cancer.
The Effect of Robotics on Bilateral Trade Flows in Global Value Chains
Authors: QI PENGBO , Chen Yifeng(Philip) , Velu Chander 
Published: August 2022

Abstract
We develop a framework to investigate the relationship between robotics and bilateral trade flows at the country level between 2000 and 2014. We find that the adoption of industrial robots improves value-added bilateral trade. However, robot adoption is also negatively associated with the growth rate of value-added bilateral trade, suggesting diminishing returns to the use of robots. This may be attributable to a lack of business model innovation compatible with robotization, a lack of relevant skills among the labor force and an uneven distribution of the trade benefit among robot-using countries. By establishing an empirical link between the use of an emerging technology, robotics, and its impact on value-added bilateral trade, we draw a number of implications for policymakers to help improve their decisions with regards to the wider context of automation in global value chains.JEL classification: F40, F62, O33, O47
Nth-order smooth positon and breather-positon solutions for a generalized integrable discrete nonlinear Schr o¨dinger equation
Authors: Tian Hongjuan , Yang Jun 
Published: August 2022

Abstract
In this paper, we investigate the smooth positon and breather-positon solutions of the a generalized integrable discrete nonlinear Schr¨ o dinger (NLS) equation by the generalized Darboux transformation (DT). Starting from the zero seed solution, the Nth-order smooth positon solutions are obtained by degenerate DT. The breather solutions including Akhmediev breather, Ma breather and space-time periodic breather are derived from the nonzero seed solution. Then the breather-positon solutions are constructed by gradual Taylor series expansion of the eigenfunctions in breather solutions. We study the effect of higher-order nonlinear terms on these discrete smooth positon solutions and breather-positon solutions, which demonstrates that the interacting region of soliton-positon and breather-positon are highly compressed by higher-order nonlinear effects, but the distance between the two positons have an opposite effect in two waveforms.
Constructed Recognition: How Nationalism Influences Public Acceptance of Domestic COVID-19 Vaccines in China
Authors: Ye Yanyu , Zhou Qian , Su Zhenhua , Gu Zheng 
Published: August 2022

Abstract

Background
Despite numbers of vaccine scandals and the potential side effects, COVID-19 vaccines have gained widespread acceptance in China. The purpose of the study was to explain why the support of vaccines is so high in China.
Methods
Based on existing literature, we proposed hypotheses from three aspects: self-interests, altruism and nationalism. Adopting data from a survey conducted in May of 2021, we used ordered logit regression models to examine the three explanations. Moreover, we explored how individuals’ trust in domestic scientists influences their assessment of the quality of COVID-19 vaccines.
Results
A total of 2038 participants completed our questionnaire online (females = 48.72%). The statistical results shows that the self-interest and altruism can partially explain public’s positive opinions toward COVID-19 vaccines. And the main finding of this paper is that the nationalistic values are important sources of their acceptance of the vaccines, for the Chinese government has further strengthened the linkage between the vaccine and patriotism. Trust in scientists, as an extension of nationalism, is another important motivation of vaccine acceptance in China, for the reputations of these experts are deliberately shaped by the government.
Conclusion
This paper finds that citizens’ high recognition of domestic vaccines is a derivative of nationalistic ideology, which implies that public’s attitudes toward vaccines are consciously constructed by the Chinese government.
The Effect of Online Social Evaluation on Mood and Cognition in Young People
Authors: Grunewald Karina , Deng Jessica , Wertz Jasmin , Schweizer Susanne 
Published: August 2022

Abstract
Adolescence is characterised by increased peer interactions and heightened sensitivity to evaluation by peers. Increasingly, young people’s social interactions and evaluation happen in online contexts. Yet, little is known about the impact of online social interaction and evaluation on adolescent emotional and cognitive functioning. The present study examined the impact of online social evaluative threat on young people’s mood and cognition and whether this varied as a function of known offline social risk and protective factors. 255 participants completed a perceptual learning task under online social evaluative threat and a perceptually-matched control condition. Participants reported a greater increase in negative mood following social evaluative threat compared to the control condition. Heightened social rejection sensitivity and lower perceived social support were associated with elevated negative mood across the study. Social evaluative threat also adversely impacted overall accuracy on the perceptual matching task, but not learning. These findings provide preliminary evidence that online social evaluative threat impacts adolescent mood and cognitive functioning.
Colla-Config: a stakeholders preferences-based approach for product lines collaborative configuration
Authors: Sassi Sihem Ben , Edded Sabrine , Mazo Raùl , Ghezala Henda Ben , Salinesi Camille 
Published: August 2022

Abstract
During collaborative configuration of software product lines (SPL), multiple stakeholders contribute together in building a single product specification. Conflicting situations can arise during the configuration process due to contradictions between some/all stakeholders' configuration choices. Detecting and resolving such situation rise two major challenges: choosing which choices to omit and taking stakeholders' preferences into account. While several approaches are available for SPL collaborative configuration, most of the existing ones either do not present detailed information on the strategies for conflict resolution or they rely on a systematic process which resolves conflicts by prioritizing configuration decisions made at earlier stage, constraining therefore some stakeholders' choices. The lack of flexibility may hinder conflict resolution as choices taken in earlier stages overlay those in later phases. To mitigate these limitations, we propose a new collaborative configuration approach (Colla-Config) which provides a preference-based conflict resolution method within a free-order configuration process; each stakeholder expresses his/her preferences through a set of substitution rules, and freely makes his/her configuration decisions towards the desired product without being constrained by the configuration decisions made by the other ones. To assess the feasibility and the usability of the proposed approach, we conducted a usability test designed by following the ISO/IEC 25062:2006 Common Industry Format for usability tests. Results of the experiments provided preliminary evidence of the approach feasibility and the tool ability to properly support the SPL collaborative configuration.
Investigation into Climate Change Effects on carbon and water fluxes, and water use efficiency of the Temperate Grassland Ecosystems in Inner Mongolia of China
Authors: Wu Zhijun , Li Qiongfang , Xu Shuhong , Chen Qihui 
Published: August 2022

Abstract
The daily gross primary productivity (GPP) and evapotranspiration (ET) in the Xilingol temperate grassland ecosystem of Inner Mongolia, China were simulated during 2003 to 2019 and under future climate change scenarios by the BioGeochemical Cycles (Biome-BGC) model, which was optimized by the system response parameter calibration method (SRPCM), the temporal variations of GPP, ET and WUE (GPP/ET) on multiple time scales were investigated, and the impacts of precipitation and temperature on them were explored. The results revealed: the BIOME-BGC model performed better optimized by SRPCM than by PEST; GPP and ET at annual and seasonal scales all showed an insignificant increasing trend; WUE at annual scale and in growing seasons all showed an insignificant increasing trend with it presenting a slight decrease trend in non-growing seasons; the intra-annual distributions of GPP, ET and WUE were very uneven with the highest GPP and ET appearing in July and the highest WUE in September; annual GPP and ET are more sensitive to the changes in precipitation than in temperature with WUE keeping relatively stable with years; precipitation is a critically controlling factor to GPP and ET in growing seasons and to ET and WUE in non-growing seasons; monthly precipitation exhibited greater influence on GPP, ET and WUE than monthly temperature with the previous month’s precipitation imposing bigger effects on GPP than the current month’s; the combined increase scenarios in temperature and precipitation impose greater impacts on GPP/ET/WUE than the ones only increasing in temperature or precipitation.