bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linking single nucleotide polymorphisms to metabolic risk and matrix remodeling in abdominal aortic aneurysms
Authors: Lim Chrysania , Pratama Muhammad Yogi , Silvestro Michele , Rivera Cristobal , Tsao Philip S. , Maegdefessel Lars , Gallagher Katherine A. , Maldonado Thomas , Ramkhelawon Bhama 
Published: September 2022

Abstract
Introduction:
Genetic hereditary predisposes to AAA. However, the pathobiological relevance of single nucleotide polymorphisms (SNPs) to the development of AAA is not fully elucidated. The present study investigated 86 AAA SNPs from GWAS and clinical cohort studies to determine their phenotypical vulnerabilities in AAA.
Methods
SNPs from GWAS catalog and available clinical cohort were collected in this study. The SNPs were annotated using snpXplorer AnnotateMe tool to identify its chromosomal position, minor allele frequency (MAF), CADD (Combined Annotation Dependent Depletion)-annotation based pathogenicity score, variant consequence, & their affected gene. Gene enrichment analysis was performed on AAA-related genes using Gene Ontology (GO) terms and clustered using REVIGO. The plug-in GeneMANIA in Cytoscape was applied to reveal an association network integration of the SNPs with associated genes and functions.
Results
15 SNPs affecting 20 genes with a CADD pathogenicity score above 10 were identified. AAA SNPs were predominantly located on chromosome 3 and 9. Stop-gained rs5516 KLK1 obtained high frequency in AAA (17.8%) and was associated with proinflammatory and vascular remodeling phenotypes. Our clinical cohort identified significant positive association of the SNPs presence with aortic diameter (P = 2.003e− 05), hypertension (P = 0.013), dyslipidemia (P = 0.042), and smoking history (P = 0.037) in AAA groups. Gene-ontology and Network association analysis showed that AAA SNPs and their associated genes could regulate signaling pathways including lipid metabolism, extracellular matrix organization, smooth muscle cell proliferation, and oxidative stress, suggesting that these AAA traits could be inheritable.
Conclusion
We show a library of inborn SNPs and associated genes that manifest in the presence of risk factors and uncovered their pathological signaling traits that are likely transmitted through familial lineage culminating in AAA development.
Removal of Metals by Sorption with Metal Concentration Colour Sensitive Azotized Polyethylene Terephthalate Adsorbent
Authors: Mwangi Isaac , Cheruiyot Nicholas , Wanjau Ruth , Ngila Jane Catherine 
Published: September 2022

Abstract
This paper reports on the preparation and modification of azotized polyethylene terephthalate (PET) as a stable and colour sensitive absorbent for metals in aqueous media and its application in the removal of heavy metal ions from water. This study successfully functionalized PET to produce an azotized material which was confirmed by FTIR (Fourier transform infrared) analysis and its metal adsorption property confirmed by FAAS (flame atomic absorption spectroscopic) analysis. The modified material exhibited colour variations upon interaction with metal ions. The material was capable of indicating when exhausted, and was then applied for the removal of the metals from water. Sorption parameters were investigated and optimized at fixed temperature (25°C). The optimum pH for the adsorption of copper, lead and chromium was 6.0 except that of cadmium was that was adsorbed at a pH value of 5.5. The uptake of the metals studied was found to be very fast as about 90% was adsorbed within the first 10 min of contact time. The adsorption of lead and cadmium prescribed to first order kinetics thus monolayer adsorption implying a chemisorption process while the adsorption of copper and chromium was of second order kinetics of multilayer adsorption. This could also be due to copper and chromium being smaller species hence being more interactive than lead and cadmium. The adsorption capacities of copper, lead, cadmium and chromium were found to be 46.47, 33.65, 70.93 and 59.06 mg g− 1 respectively. The metal ions attached on the adsorbent were easily stripped of by the use of 1.0 M nitric acid, hence easily regeneratable. The results obtained confirmed that azotized PET has potential application as a colour sensitive sorbent for the removal of heavy metal pollutants from water.
Anatomical Features of Proximal Fifth Metatarsal Fracture: A Radiographic Study
Authors: Li Ming-hui , Chen Xu , Huang Lei , You Gui-xuan , Tang Xiao-gao , Li Bing-kun , Zhou Xin , Wang Ding-xuan , Zhang Lei 
Published: September 2022

Abstract

Background
The existing study is not in-depth enough to address the high risk of fifth metatarsal proximal fracture nonunion. The purpose of this study was to investigate basic anatomical structure characteristics of the fifth metatarsal and to provide a clinical anatomical basis for the prevention and treatment of basal fractures of the fifth metatarsal.
Methods
Medical records were obtained and retrospectively reviewed to determine the differences in foot type and metatarsal morphology between fractured and non-fractured participants. Some related indicators of the fifth metatarsal were measured and analyzed anatomical data for clinical support.
Results
Seventy normal metatarsals and one hundred and twenty-three patients were included in the analysis. In comparison between normal and proximal fractures of the fifth metatarsal, we found that there was a significant difference in the lateral separation angle on the foot oblique radiographs (P < 0.05). In addition, in fractures, there was no difference between different injured areas. All lengths except the length of interface between fifth metatarsal and fourth metatarsal had statistical difference between men and women in gender (P < 0.05), and there were statistical differences in the contact length of joint surface between fifth metatarsal and dice (P < 0.05), the length of interface between fifth metatarsal and fourth metatarsal (P < 0.05), the width of the fifth metatarsal (P < 0.05) and the fifth metatarsophalangeal angle (P < 0.05) on the measurement side.
Conclusion
In the prevention of proximal fifth metatarsal fractures, special attention should be paid to the prevention of left foot and the recovery of lateral separation angle. In addition, due to differences in length, auxiliary supports and screws should be used longer in males than in females during treatment.
Genetically engineered macrophage membrane-coated nanoparticles for enhanced tumor targeting and synergistic cancer therapy
Authors: Qin Weijun , Zhang Keying , Han Donghui , Wang Jingwei , Li Yu , Xu Chao , Yang Xiaojiang , Yang Fa , Liu Shaojie , Zhao Xiaolong , Li Hongji , Jiang Yao , Ma Shanjin , Zhang Jingliang , Jiao Jianhua , Bu Te , Zhang Qiang , Zhang Rui , Yang Angang , Zhang Ruili , Wang Zhongliang , Wen Weihong 
Published: September 2022

Abstract
The poor targeting capability of systemically administered drugs is a major hurdle in designing effective therapies with minimal off-target side effects. Here, as a proof of concept, we propose a genetic engineering strategy to embed a prostate-specific membrane antigen (PSMA)-targeting antibody fragment (gy-1) in the macrophage membrane, which is then coated onto core-shell Fe3O4@Au nanoparticles to produce a biomimetic nanoplatform, Magic. The results indicate that Magic exhibits not only high specificity and affinity towards prostate tumor cells in vitro and in vivo, but also effective immunomodulatory capability. Upon further encapsulation with the anti-tumor drug DM1, Magic shows superior synergistic effects in highly targeted chemo-photothermal therapy and potent immunotherapy, eliciting significant therapeutic efficacy against tumor growth, micro-metastasis and concomitant damage without overt toxicity. These findings reveal that Magic may provide a promising platform for enhancing cancer treatment by overcoming undesired drug delivery barriers and the tumor immune microenvironment.
Highly sensitive and selective detection of the pancreatic cancer biomarker CA 19-9 with the electrolyte-gated MoS 2 -based field-effect transistor immunosensor
Authors: Rahmani Hedyeh , Majd Samira Mansouri , Salimi Abdollah 
Published: September 2022

Abstract
Background: Since the evaluation of CA 19-9 antigen level in human serum is crucial for the early diagnosis of a vast range of diseases, especially pancreatic cancer, it is important to apply a simple, rapid and sensitive detection method. We employed an electrolyte-gated field-effect transistor with MoS2 nanosheets channel as an immunosensor for recognition of CA 19-9 tumor marker.
Method: To obtain MoS2nanosheets, the liquid-phase exfoliation method was carried out by dispersing MoS2 crystals in N, N-dimethylformamide. After that, the dispersed MoS2 nanosheets were dropped onto the region between the source and drain electrodes to create a semiconducting channel of MoS2. Later, the MoS2 channel surface was modified by employing 1-naphthylamine (NA) and glutaraldehyde (GA) for covalent immobilization of antibody 19-9 on the surface of the MoS2 nanosheets. The decreasing of source- drain current of the proposed FET in the presence of CA 19-9 antigen concentration measured.
Results: Electrical measurements revealed the depletion mode n-type behavior of MoS2nanosheets with the FET mobility of 0.02 cm2 V-1 s-1, current on/off ratio of 883.96, and the subthreshold swing of 795.54 mV/decade. Due to the n-type behavior of the MoS2-based FET immunosensor, increasing the concentration of the CA 19-9 antigen from 1.0×10-12 U/ml to 1.0×10-4U/ml resulted in the decrease of the source-drain currents. Compared to other techniques, using MoS2-based FET immunosensor for CA 19-9 antigen detection exhibited a lower detection limit of 2.8×10-13 U/ml and a wide linear range. The designed MoS2-based FET immunosensor, owning a great selectivity, was operated precisely for trace amounts of real human serum samples.
Conclusions: Possessing vast beneficial properties makes the MoS2-based FET immunosensor a marvelous alternative for detecting even the lowest concentration of CA 19-9 antigen in human serum samples in the early stages of pancreatic cancer, to improve the chance of curing the disease.
A prospective multicenter phase II study of FOLFIRINOX as a first-line treatment for patients with advanced and recurrent biliary tract cancer
Authors: Takahara Naminatsu , Nakai Yousuke , Isayama Hiroyuki , Sasaki Takashi , Morine Yuji , Watanabe Kazuo , Ueno Makoto , Ioka Tatsuya , Kanai Masashi , Kondo Shunsuke , Okano Naohiro , Koike Kazuhiko 
Published: September 2022

Abstract
Purpose: Given the promising activity and tolerability of FOLFIRINOX as a second-line treatment for advanced biliary tract cancer (BTC), it can be an attractive first-line treatment option as well.
Materials and Methods: This is a single-arm, open-label, multicenter phase II study to evaluate the safety and efficacy of FOLFIRINOX as a first-line treatment for patients with advanced BTC. Primary endpoint was progression-free survival (PFS), and the secondary endpoints included overall survival (OS), tumor response and safety. This study defined primary endpoint might be met when the lower limit value of 80% confidence interval [CI] of the median PFS ≥ 6.0 months.
Results: Between June 2016 and March 2020, 35 BTC patients (21 intrahepatic, 10 extrahepatic, 2 gallbladder, 2 ampulla) including 26 unresectable and 9 recurrent disease were enrolled. After a median follow-up of 13.9 months, the median PFS and OS were 7.4 (80% CI, 5.5-7.5) and 14.7 (80% CI, 11.8-15.7) months, respectively. Complete response was achieved in 1 (2.9%) and partial response in 10 (28.6%), giving an objective response rate of 31.4% and disease control rate of 74.3%. Major grade 3-4 adverse events included neutropenia (54.3%), leukopenia (34.4%), febrile neutropenia (17.1%), thrombocytopenia (8.6%), cholangitis (8.6%), anemia, nausea, diarrhea, and peripheral sensory neuropathy (2.9% each).
Conclusion:.FOLFIRINOX was well tolerable in patients with advanced BTC, however, this study did not meet the primary endpoint to conduct a phase III trial. Thus, further explorations are required to find a subset of patients and/or certain clinical scenario which might be beneficial from FOLFIRINOX.
Impulse Noise Reduction using Isolated Vector Median Filtering using K- Means Clustering in Digital Color Images with Application to Medical Diagnosis of SARS-COV-2 Covid19 Disease and Visual Tracking
Authors: Gantenapalli Srinivasa R. , Choppala Praveen B. , Meka James S. 
Published: September 2022

Abstract
This paper proposes a new approach for filtering out impulse noise in digital color images. This work is of critical interest in biomedical imaging, visual tracking, etc. The conventional filtering methods operate by applying a noise reduction scheme, generally the vector median filtering approach and its variants, for the center pixel of a suitably chosen window that iteratively slides along the entire image. These methods consider the window in its entirety in the filtering process. This consideration, however, comprehends the noise within the noisy pixels in the filtering process and could prove detrimental to the overall output. The method proposed in this paper operates by clustering the pixels in the chosen window into two groups, one that corresponds to the pixel intensities that lie in the signal space and the other to those that lie in the noise space. The motivating rationale for this clustering scheme is to marginalize those pixels that lie in the noise space that seemingly do not contribute to the information in the image. The median filter is then applied to the pixels that contribute to the signal, in isolation of the color components, to filter out the impulse noise. Simulation results show that the proposed method outperforms conventional filtering methods in terms of noise reduction and structural similarity and thus validates the proposed approach. The proposed method is applied to analyze CT scans for improved diagnosis of SARS-COV-2 Covid19 disease. The method is also applied to a visual tracking example as a preprocessor.
Climate Trends, variability, and impacts of ENSO on rainfall amount in Ethiopia: A Case study in Western Amhara National Regional State
Authors: Amare Zerihun , Geremew Belayneh , Kebede Nigatu , Amera Sisaynew 
Published: September 2022

Abstract
Agricultural production in Ethiopia is predominantly rainfed. Variation in rainfall and El Niño Southern Oscillation (ENSO) affects the agricultural production system in the country. This needs a close study ontrends, variability of rainfall, and impacts of El Niño Southern Oscillation (ENSO) on rainfall amount to suggest possible adaptation strategies. The study was in Western Amhara of Ethiopia. Monthly rainfall data were collected from fifteen meteorological stations of Western Amhara and selected El Niño and La Niña years from National Oceanic and Atmospheric Administration (NOAA) from 1986 to 2015.Following data quality checking and inspection, the monthly rainfall data of the selected stations were arranged in Microsoft Excel Spread Sheet and analyzed using XLSTAT software. Coefficient of variation and the Mann Kendall non-parametric statistical test was applied to study trends and variability of rainfall and temperature in Western Amhara.Thelong-term recorded annual rainfall data indicated that there was an increasing trend from 1986 to 2015, but not significant. The rainfall variability was less (CV = 8.6%); also, the mean monthly rainfall of Western Amhara decreased during El Niño years and increased during La Niña years especially in the rainy season (JJAS) over30 years.
Corneal Hysteresis as a Marker for Patients with Secondary Glaucoma
Authors: Oydanich Marko , Uppuluri Aditya , Sadek Hadeel , Lu Ziyao , Khouri Albert S 
Published: September 2022

Abstract

Purpose
To investigate and compare the association of corneal hysteresis (CH) in patients with secondary glaucoma to those with primary open-angle glaucoma (POAG). Additionally, to determine the consistency of CH measurements in patients with secondary glaucoma.
Methods
A total of 84 patients (121 eyes) were prospectively included in this study. 23 patients (46 eyes) were healthy controls, 24 patients (40 eyes) were diagnosed with POAG, and 27 patients (35 eyes) were diagnosed with a form of secondary glaucoma. CH and intraocular pressure (IOP) were measured using the Ocular Response Analyzer. Three measurements per eye were performed and used for the analysis and to determine fluctuations in CH data. One-way ANOVA with post-hoc Bonferroni analysis and Chi-Squared testing was done to determine differences between groups.
Results
All patients were matched for age. Patients in both POAG and secondary glaucoma groups were matched for age and IOP. All groups had similar sex and racial compositions as well as similar proportions of diabetes, hypertension, and hyperlipidemia. CH was lower (p < 0.05) in patients with POAG (9.32 ± 1.64) and secondary glaucoma (7.89 ± 3.18) when compared to healthy controls (11.16 ± 1.60). Fluctuations in CH measurements were minimal in all groups. Further analysis of the secondary glaucoma group revealed no differences in CH between different types of secondary glaucoma (p > 0.05).
Conclusion
Patients with secondary glaucoma have lower CH when compared to POAG or control groups. The ORA exhibits precision of CH measurements for control, POAG, and secondary glaucoma groups.
Psychiatric adverse reaction to COVID-19 vaccine booster presenting as first-episode acute mania with psychotic features: A case report
Authors: Kita Akira , Fuyuno Yuka , Matsuura Hiroki , Yamaguchi Yasunari , Okuhira Kazuya , Kimoto Sohei 
Published: September 2022

Abstract
Background
A few case series on psychiatric adverse reactions to COVID-19 vaccines have been reported despite the absence of a history of psychiatric disorders. Herein, we report a case of a first episode of acute mania with psychotic features receival of the third mRNA-1273 vaccine.
Case presentation
A 37-year-old man developed talkativeness, grandiose delusions, emotional instability, sleeplessness, excitement, hyperactivity and suicidal behavior 4 days after receiving the third mRNA-1273 COVID-19 vaccine. On the 9thdays after vaccination, he was diagnosed with first-episode acute mania with psychotic features and admitted to the psychiatric institute for the first time. After olanzapine administration, the psychiatric symptoms improved within 4 weeks.
Conclusions
To our knowledge, this is the first report of a first episode of acute mania with psychiatric features associated with the mRNA-1273 vaccine booster. Psychiatrists should be aware of this possibility and be attentive to such a rare and severe adverse effect that could occur within 10 days of vaccination.
Similarity Measures for Recommender Systems: Drawbacks and Neighbors Formation
Authors: Al-Shamri Mohammad 
Published: September 2022

Abstract
Similarity measures are crucial for electing neighbors for the users of recommender systems. However, the massive amount of the processed data in such applications may hide the inner nature of the utilized similarity measures. This paper devotes lots of studies to three standard similarity measures based on many synthetic and real datasets. The aim is to uncover the hidden nature of such measures and conclude their suitability for the recommender systems under different scenarios. Moreover, we propose a novel similarity measure called the normalized sum of multiplications (NSM) and two different variants of it. For experimentation, we examine all measures at three levels; a toy example, synthetic datasets, and real-world datasets. The results show that sometimes Pearson correlation coefficient and cosine similarity exclude similar neighbors in favor of less valuable ones. The former measures the correlation direction, while the latter measures the angle. However, both direction and angle are not similarity but an indication to it and can have the same values for two far vectors. On the other hand, the proposed similarity measure constantly reveals the exact similarity and tracks the closest neighbors. The results prove its robustness and its very good predictive accuracy compared to the traditional ones.
GPM6A Variant (4:175633071A&gt;G) Association with Depression and Claustrophobia-like Disorders in Pakistani Population
Authors: Arif Rida , Bajwa Muhammad Labeeb , Gill Sehreem , Saif Rashid 
Published: September 2022

Abstract
Neuropsychiatric disorders are getting special consideration in all populations around the globe due to its frightening occurrence in the current era of socio-economic competitiveness. General phobias are one of its major categories, particularly, claustrophobia which is the fear of confined places with varied intensities among people of different origins. In general, depression is a serious mental illness that affects how you feel, think, and respond to certain improvised intense situations. GPM6A-deficient mice foster neuropsychiatric abnormalities which are provoked by stress-induced environments that ultimately translate into depression and claustrophobia-like behavioral responses. The current study reported GPM6Avariant 4:175633071A>G association with depression and claustrophobia-like disorders within the Pakistani population. This gene is stimulated by stress in humans, located on 4q32-q34 that encodes a protein called glycoprotein M6A which ultimately aids in synapse formation in the human brain. The subject mRNA variant r.2778T>C transcript ID: NM_005277.5 (rs17061735A>G) located on the 8thexon genotyped here, and a total of 53 samples were screened (cases=28, controls=25). This pilot study revealed that 21 & 7 individuals were homozygous wild-type and heterozygous respectively among the case-cohort, while all samples were found homozygous wild-type in the control-cohort. Alternative allele frequency among the cases & controls was 0.125 & zero respectively with χ2 association p-value of 9.68×10-3. Furthermore, the subject variant may be genotyped with a large sample size for more robust statistical significance, alternatively, whole-genome association studies (GWAS) may be designed to have a better insight of this complex disorder in the socio-economically suppressed societies across the world.
Novel 2D photocatalyst of copper-doped carbon quantum dot CD(Cu) loaded with ultrathin Ni-MOL for degradation of tetracycline
Authors: Li Zuyu , Li Da , Yu Fei , Dong Liming , Zang Lihua , Zhang Junjie , Shi Linglong , Ge Xiuli , Guo Shuangzhen , Zheng Yixuan 
Published: September 2022

Abstract
Broadening the light absorption range and suppressing the carrier complexation are the two keys to enhance the photocatalytic activity. In this work, a novel two-dimensional (2D) photocatalyst was successfully prepared by modified hydrothermal method and applied in tetracycline (TC) degradation. The degradation rate of CD(Cu)-Ni-MOL for TC reached 93.5% within 60 min under the visible light condition. The improved photocatalytic performance of CD(Cu)-Ni-MOL was attributed to the constructed 2D layered structure and the special properties of CD(Cu). The doped Cu in carbon dots (CDs) exhibited excellent photocatalytic performance among the elements of Cu, Zn, Ni, Co and Fe. The order of photocatalytic performance improvement was Cu &gt; Zn &gt; Ni &gt; Co &gt; Fe. In addition, a possible degradation pathway for TC was proposed. This work confirms the great potential of CD(Cu)-Ni-MOL as a highly efficient photocatalyst in removing tetracycline pollutants in water.