bluuebunny/crossref_metadata_2025_split huggingface dataset:
The formative international law studies of Judge Shi Jiuyong
Authors: Chen Li 
Published: October 2022

AbstractShi Jiuyong was an eminent Chinese international lawyer who became the first Chinese national to helm the International Court of Justice. This tribute examines Shi’s underexplored university education years, illuminating how these early experiences proved formative in his subsequent years as an international law practitioner, scholar and judge. In doing so, this tribute explores the factors that animated Shi’s choices and focuses, giving context to his slew of admirable achievements later in life.
Adherence to dietary guidelines and risk of dementia: a prospective cohort study of 94 184 individuals
Authors: Kjeldsen E. W. , Thomassen J. Q. , Rasmussen K. L. , Nordestgaard B. G. , Tybjærg-Hansen A. , Frikke-Schmidt R. 
Published: October 2022

Aims
Recent estimates suggest that 40% of dementia cases could be avoided by treating recognised cardiovascular risk factors such as hypertension, diabetes, smoking and physical inactivity. Whether diet is associated with dementia remains largely unknown. We tested if low adherence to established dietary guidelines is associated with elevated lipids and lipoproteins and with increased risk of Alzheimer's disease and non-Alzheimer's dementia – a dementia subtype with a high frequency of cardiovascular risk factors.

Methods
We used the prospective Copenhagen General Population Study including 94 184 individuals with dietary information and free of dementia at baseline. Mean age at study entry was 58 years, and 55% (N = 51 720) were women and 45% (N = 42 464) were men. Adherence to dietary guidelines was grouped into low, intermediate and high adherence based on food frequency questionnaires. Main outcomes were non-Alzheimer's dementia and Alzheimer's disease.

Results
Low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol and plasma triglyceride levels were higher in individuals with intermediate and low adherence to dietary guidelines compared with individuals with high adherence (all p for trends <0.001). Age and sex-adjusted hazard ratios (HRs) for non-Alzheimer's dementia v. individuals with high adherence were 1.19 (95% confidence interval 0.97–1.46) for intermediate adherence, and 1.54 (1.18–2.00) for low adherence. Corresponding HRs in multivariable-adjusted models including APOE genotype were 1.14 (0.92–1.40) and 1.35 (1.03–1.79). These relationships were not observed in individuals on lipid-lowering therapy.

Conclusions
Low adherence to national dietary guidelines is associated with an atherogenic lipid profile and with increased risk of non-Alzheimer's dementia – the subtype of dementia with a high frequency of vascular risk factors. This study suggests that implementation of dietary guidelines associated with an anti-atherogenic lipid profile could be important for prevention of non-Alzheimer's dementia.
Effect of Synoptic‐Scale Dynamics on the Vertical Distribution of Tropospheric Ozone Over the Arabian Sea and the Indian Ocean During the Boreal Winter of 2018
Authors: Satheesh Chandran P. R. , Sunilkumar S. V. , Muhsin M. , Alladi Hemanth Kumar 
Published: October 2022

AbstractOzone (O3) and relative humidity profiles obtained from in situ electrochemical concentration cell ozonesonde‐radiosonde observations over the Arabian Sea and the Indian Ocean from 16 January to 14 February 2018 during the Integrated Campaign for Aerosols gases and Radiation Budget cruise were analyzed. On the basis of the prevailing synoptic conditions during the cruise period, the cruise track was divided into three legs which were studied separately. The main objective of this study was to investigate the influence of prevailing synoptic scale dynamics and transport on the vertical distribution of ozone in the troposphere, especially in the tropical tropopause layer (TTL) region. Tropospheric ozone exhibits pronounced latitude variations over the Arabian Sea and the Indian Ocean with very high values (∼60–70 ppbv) above the marine boundary layer near the Indian landmass. Distinct ozone‐rich plume‐like structures are observed in the free troposphere around 1–3 and 4–5 km. At around 1–3 km, the ozone plume was maintained by the continental outflows from the Indian sub‐continent. The mid‐tropospheric (4–5 km) high ozone‐low water vapor layer is hypothesized to be associated with the equatorward return flow of the Hadley circulation. Enhanced (declined) ozone is observed below 12 km altitude in the descending (ascending) branch of Hadley circulation. The ozone distribution in the TTL shows distinct structures associated with the prevailing synoptic dynamics and transport during respective legs. Evidences of stratospheric intrusion and air mass transport from biomass burning locations are seen regarding upper tropospheric ozone enhancements.
A Highly Depleted and Subduction‐Modified Mantle Beneath the Slow‐Spreading Mohns Ridge
Authors: Bjerga A. , Stubseid H. H. , Pedersen L. E. R. , Beinlich A. , Pedersen R. B. 
Published: October 2022

AbstractThe Mohns Ridge is a very slow‐spreading ridge that, together with the Knipovich Ridge, marks the boundary between the North American and Eurasian plates in the Norwegian‐Greenland Sea. In this study, we report the major and trace element composition of spatially associated basalts and peridotites from a gabbro‐peridotite complex ∼20 km west of the Mohns Ridge rift flank. Formation of the ∼4–5 Myr crustal section involved accretion of normal mid‐ocean ridge basalts with Na‐content suggesting derivation from a depleted mantle source. This is consistent with the degree of partial melting estimated for clinopyroxene poor harzburgites using the Cr‐number of spinel (14%–18%) and rare earth element modeling of orthopyroxene (16%–24%) and reconstructed whole‐rock composition (14%–20%). If all the melting took place beneath the paleo‐Mohns Ridge, a crustal thickness of ∼7–8 km is expected, which is nearly double the observed thickness. Orthopyroxene trace elements are not consistent with typical fractional melting expected for mid‐ocean ridges but rather resemble that seen in supra‐subduction zone peridotites. The geochemistry of both the basalts and the peridotites suggests that a water‐rich slab flux in the past has influenced the mantle source. In turn, this caused hydrous melting which increased the depletion of the pyroxene components, leading to a highly depleted mantle that is now underlying much of the Arctic Mid‐Ocean Ridges and represents the source for the spreading related magmatism.
Spatiotemporal Evolution of the Seismicity in the Alto Tiberina Fault System Revealed by a High‐Resolution Template Matching Catalog
Authors: Essing David , Poli Piero 
Published: October 2022

AbstractThe Alto Tiberina Fault system, located in the Northern Apennines (Italy), consists of a low angle normal fault (LANF) which radiates micro‐seismicity that can be explained by continuous creep. On top of the LANF, a network of syn‐ and antithetic high angle faults frequently hosts seismic swarms, one of which has been associated with a transient aseismic deformation signal. To study in detail the seismicity and its relationships with aseismic deformation processes occurring in this fault system, we apply template matching on seismic data recorded at an array of borehole stations, to derive a high‐resolution earthquake catalog. Thanks to the additionally detected events, we are able to reveal time periods of increased spatial‐ and temporal clustering during an aseismic deformation event. This reflects the complex evolution of aseismic slip together with the complexity of the shallow fault system. Along the LANF, we observe a bimodal type of seismicity, with diffuse seismicity active continuously, and short‐lived bursts of seismicity that could indicate rapid fluid releases. We additionally identify repeating earthquakes. These events not necessarily match a simple creep model and therefore open the possibility for new models to explain the seismicity along the LANF.
Global Variations in Water Vapor and Saturation State Throughout the Mars Year 34 Dusty Season
Authors: Holmes J. A. , Lewis S. R. , Patel M. R. , Alday J. , Aoki S. , Liuzzi G. , Villanueva G. L. , Crismani M. M. J. , Fedorova A. A. , Olsen K. S. , Kass D. M. , Vandaele A. C. , Korablev O. 
Published: October 2022

AbstractTo understand the evolving martian water cycle, a global perspective of the combined vertical and horizontal distribution of water is needed in relation to supersaturation and water loss and how it varies spatially and temporally. The global vertical water vapor distribution is investigated through an analysis that unifies water, temperature and dust retrievals from several instruments on multiple spacecraft throughout Mars Year (MY) 34 with a global circulation model. During the dusty season of MY 34, northern polar latitudes are largely absent of water vapor below 20 km with variations above this altitude due to transport from mid‐latitudes during a global dust storm, the downwelling branch of circulation during perihelion season and the intense MY 34 southern summer regional dust storm. Evidence is found of supersaturated water vapor breaking into the northern winter polar vortex. Supersaturation above around 60 km is found for most of the time period, with lower altitudes showing more diurnal variation in the saturation state of the atmosphere. Discrete layers of supersaturated water are found across all latitudes. The global dust storm and southern summer regional dust storm forced water vapor at all latitudes in a supersaturated state to 60–90 km where it is more likely to escape from the atmosphere. The reanalysis data set provides a constrained global perspective of the water cycle in which to investigate the horizontal and vertical transport of water throughout the atmosphere, of critical importance to understand how water is exchanged between different reservoirs and escapes the atmosphere.
Explainable Artificial Intelligence for Bayesian Neural Networks: Toward Trustworthy Predictions of Ocean Dynamics
Authors: Clare Mariana C. A. , Sonnewald Maike , Lguensat Redouane , Deshayes Julie , Balaji V. 
Published: October 2022

AbstractThe trustworthiness of neural networks is often challenged because they lack the ability to express uncertainty and explain their skill. This can be problematic given the increasing use of neural networks in high stakes decision‐making such as in climate change applications. We address both issues by successfully implementing a Bayesian Neural Network (BNN), where parameters are distributions rather than deterministic, and applying novel implementations of explainable AI (XAI) techniques. The uncertainty analysis from the BNN provides a comprehensive overview of the prediction more suited to practitioners' needs than predictions from a classical neural network. Using a BNN means we can calculate the entropy (i.e., uncertainty) of the predictions and determine if the probability of an outcome is statistically significant. To enhance trustworthiness, we also spatially apply the two XAI techniques of Layer‐wise Relevance Propagation (LRP) and SHapley Additive exPlanation (SHAP) values. These XAI methods reveal the extent to which the BNN is suitable and/or trustworthy. Using two techniques gives a more holistic view of BNN skill and its uncertainty, as LRP considers neural network parameters, whereas SHAP considers changes to outputs. We verify these techniques using comparison with intuition from physical theory. The differences in explanation identify potential areas where new physical theory guided studies are needed.
Cut-off values of serum interleukin-6 for culture-confirmed sepsis in neonates
Authors: Küng Erik , Unterasinger Lukas , Waldhör Thomas , Berger Angelika , Wisgrill Lukas 
Published: October 2022

AbstractIntroductionNeonatal sepsis accounts for 0.97% of all disability-adjusted life years worldwide. Interleukin-6 has been used in sepsis diagnosis, but cut-off values are missing.MethodsNeonates admitted to the neonatal wards with measurements of serum interleukin-6 born between September 2015 and September 2019 were retrospectively analysed. Mean serum interleukin-6 values of patients who never had increased laboratory parameters of infection nor died during their stay and mean interleukin-6 values on the day of blood sampling for a later positive culture in patients with culture-confirmed sepsis were analysed for each time period.ResultsIn all, 8.488 values in 1.695 neonates, including 752 very-preterm-infants and 701 very-low-birthweight infants, were analysed. The AUC for interleukin-6 was 0.84–0.91 in all neonates, 0.88–0.89 in very-preterm and 0.89–0.91 in very-low-birthweight infants. Using interleukin-6 cut-off values of 80 pg/ml on day of life 1, 40 pg/ml on day of life 2–7 and 30 pg/ml after day of life 7, a sensitivity of 75% and a specificity of 81% for culture-confirmed sepsis were achieved. In very-preterm infants, the corresponding values were 74% for sensitivity and 83% for specificity and in very-low-birthweight infants 74% and 86%, respectively.ConclusionSerum interleukin-6 has high accuracy for the detection of neonatal sepsis.ImpactSerum interleukin-6 can be used with high accuracy to detect sepsis in neonates with the cut-off values of 80 pg/ml on day of life 1, 40 pg/ml on day of life 2–7 and 30 pg/ml after day of life 7.Serum interleukin-6 can be used with high accuracy to detect sepsis in neonates and very-preterm as well as very-low-birthweight infants.Interleukin-6 values display distinct cut-off values depending on the chronological age of the infant.Our article provides the first cut-off values for interleukin-6 in the first days of life in neonates.
Prenatal ethanol exposure causes anxiety-like phenotype and alters synaptic nitric oxide and endocannabinoid signaling in dorsal raphe nucleus of adult male rats
Authors: Oubraim Saida , Wang Ruixiang , Hausknecht Kathryn , Kaczocha Martin , Shen Roh-Yu , Haj-Dahmane Samir 
Published: October 2022

AbstractMood disorders, including anxiety and depression caused by prenatal ethanol exposure (PE) are prevalent conditions in fetal alcohol spectrum disorders (FASDs). Prenatal ethanol exposure is associated with persistent dysfunctions of several neurotransmitter systems, including the serotonin (5-HT) system, which plays a major role in mood regulation and stress homeostasis. While PE is known to disrupt the development of the 5-HT system, the cellular mechanisms by which it alters the function of dorsal raphe nucleus (DRn) 5-HT neurons and their synaptic inputs remain unknown. Here, we used a second-trimester binge-drinking pattern PE (two daily gavages of 15% w/v ethanol at 3 g/kg, 5–6 h apart) during gestational days 8 - 20 and measured anxiety-like behaviors of adult male rats using the elevated plus (EPM) and zero (ZM) mazes. We also employed ex-vivo electrophysiological and pharmacological approaches to unravel the mechanisms by which PE alters the excitability and synaptic transmission onto DRn 5-HT neurons. We found that PE enhanced anxiety-like behaviors in adult male rats and induced a persistent activation of DRn 5-HT neurons. The PE-induced activation of DRn 5-HT neurons was largely mediated by potentiation of DRn glutamate synapses, which was caused by activation of the nitrergic system and impaired endocannabinoid signaling. As such, the present study reveals “push-pull” effects of PE on nitrergic and eCB signaling, respectively, which mediate the enhanced activity of DRn 5-HT neurons and could contribute to anxiety-like behaviors observed in animal model of FASD.
Humidity-dependent lubrication of highly loaded contacts by graphite and a structural transition to turbostratic carbon
Authors: Morstein Carina Elisabeth , Klemenz Andreas , Dienwiebel Martin , Moseler Michael 
Published: October 2022

AbstractGraphite represents a promising material for solid lubrication of highly loaded tribological contacts under extreme environmental conditions. At low loads, graphite’s lubricity depends on humidity. The adsorption model explains this by molecular water films on graphite leading to defect passivation and easy sliding of counter bodies. To explore the humidity dependence and validate the adsorption model for high loads, a commercial graphite solid lubricant is studied using microtribometry. Even at 1 GPa contact pressure, a high and low friction regime is observed - depending on humidity. Transmission electron microscopy reveals transformation of the polycrystalline graphite lubricant into turbostratic carbon after high and even after low load (50 MPa) sliding. Quantum molecular dynamics simulations relate high friction and wear to cold welding and shear-induced formation of turbostratic carbon, while low friction originates in molecular water films on surfaces. In this work, a generalized adsorption model including turbostratic carbon formation is suggested.
Membrane-assisted assembly and selective secretory autophagy of enteroviruses
Authors: Dahmane Selma , Kerviel Adeline , Morado Dustin R. , Shankar Kasturika , Ahlman Björn , Lazarou Michael , Altan-Bonnet Nihal , Carlson Lars-Anders 
Published: October 2022

AbstractEnteroviruses are non-enveloped positive-sense RNA viruses that cause diverse diseases in humans. Their rapid multiplication depends on remodeling of cytoplasmic membranes for viral genome replication. It is unknown how virions assemble around these newly synthesized genomes and how they are then loaded into autophagic membranes for release through secretory autophagy. Here, we use cryo-electron tomography of infected cells to show that poliovirus assembles directly on replication membranes. Pharmacological untethering of capsids from membranes abrogates RNA encapsidation. Our data directly visualize a membrane-bound half-capsid as a prominent virion assembly intermediate. Assembly progression past this intermediate depends on the class III phosphatidylinositol 3-kinase VPS34, a key host-cell autophagy factor. On the other hand, the canonical autophagy initiator ULK1 is shown to restrict virion production since its inhibition leads to increased accumulation of virions in vast intracellular arrays, followed by an increased vesicular release at later time points. Finally, we identify multiple layers of selectivity in virus-induced autophagy, with a strong selection for RNA-loaded virions over empty capsids and the segregation of virions from other types of autophagosome contents. These findings provide an integrated structural framework for multiple stages of the poliovirus life cycle.
Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target
Authors: Cho Heewon , Kwon Haw-Young , Sharma Amit , Lee Sun Hyeok , Liu Xiao , Miyamoto Naoki , Kim Jong-Jin , Im Sin-Hyeog , Kang Nam-Young , Chang Young-Tae 
Published: October 2022

AbstractMacrophages play crucial roles in protecting our bodies from infection and cancers. As macrophages are multi-functional immune cells, they have diverse plastic subsets, such as M1 and M2, derived from naïve M0 cells. Subset-specific macrophage probes are essential for deciphering and monitoring the various activation of macrophages, but developing such probes has been challenging. Here we report a fluorescent probe, CDr17, which is selective for M1 macrophages over M2 or M0. The selective staining mechanism of CDr17 is explicated as Gating-Oriented Live-cell Distinction (GOLD) through overexpressed GLUT1 in M1 macrophages. Finally, we demonstrate the suitability of CDr17 to track M1 macrophages in vivo in a rheumatoid arthritis animal model.
Structural basis for specific inhibition of the deubiquitinase UCHL1
Authors: Grethe Christian , Schmidt Mirko , Kipka Gian-Marvin , O’Dea Rachel , Gallant Kai , Janning Petra , Gersch Malte 
Published: October 2022

AbstractUbiquitination regulates protein homeostasis and is tightly controlled by deubiquitinases (DUBs). Loss of the DUB UCHL1 leads to neurodegeneration, and its dysregulation promotes cancer metastasis and invasiveness. Small molecule probes for UCHL1 and DUBs in general could help investigate their function, yet specific inhibitors and structural information are rare. Here we report the potent and non-toxic chemogenomic pair of activity-based probes GK13S and GK16S for UCHL1. Biochemical characterization of GK13S demonstrates its stereoselective inhibition of cellular UCHL1. The crystal structure of UCHL1 in complex with GK13S shows the enzyme locked in a hybrid conformation of apo and Ubiquitin-bound states, which underlies its UCHL1-specificity within the UCH DUB family. Phenocopying a reported inactivating mutation of UCHL1 in mice, GK13S, but not GK16S, leads to reduced levels of monoubiquitin in a human glioblastoma cell line. Collectively, we introduce a set of structurally characterized, chemogenomic probes suitable for the cellular investigation of UCHL1.
Deforestation intensifies daily temperature variability in the northern extratropics
Authors: Ge Jun , Liu Qi , Zan Beilei , Lin Zhiqiang , Lu Sha , Qiu Bo , Guo Weidong 
Published: October 2022

AbstractWhile the biogeophysical effects of deforestation on average and extreme temperatures are broadly documented, how deforestation influences temperature variability remains largely unknown. To fill this knowledge gap, we investigate the biogeophysical effects of idealized deforestation on daily temperature variability at the global scale based on multiple earth system models and in situ observations. Here, we show that deforestation can intensify daily temperature variability (by up to 20%) in the northern extratropics, particularly in winter, leading to more frequent rapid extreme warming and cooling events. The higher temperature variability can be attributed to the enhanced near-surface horizontal temperature advection and simultaneously is partly offset by the lower variability in surface sensible heat flux. We also show responses of daily temperature variability to historical deforestation and future potential afforestation. This study reveals the overlooked effects of deforestation or afforestation on temperature variability and has implications for large-scale afforestation in northern extratropic countries.
Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage
Authors: Balasooriya Gayan I. , Spector David L. 
Published: October 2022

AbstractEach mammalian autosomal gene is represented by two alleles in diploid cells. To our knowledge, no insights have been made in regard to allele-specific regulatory mechanisms of autosomes. Here we use allele-specific single cell transcriptomic analysis to elucidate the establishment of monoallelic gene expression in the cardiac lineage. We find that monoallelically expressed autosomal genes in mESCs and mouse blastocyst cells are differentially regulated based on the genetic background of the parental alleles. However, the genetic background of the allele does not affect the establishment of monoallelic genes in differentiated cardiomyocytes. Additionally, we observe epigenetic differences between deterministic and random autosomal monoallelic genes. Moreover, we also find a greater contribution of the maternal versus paternal allele to the development and homeostasis of cardiac tissue and in cardiac health, highlighting the importance of maternal influence in male cardiac tissue homeostasis. Our findings emphasize the significance of allele-specific insights into gene regulation in development, homeostasis and disease.