bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Unilateral Stimulation in Parkinson's Disease: A Randomized Double-Blind Crossover Trial
Authors: Zeng Zhitong , Wang Linbin , Shi Weikun , Xu Lu , Lin Zhengyu , Xu Xinmeng , Huang Peng , Pan Yixin , Chen Zhonglue , Ling Yun , Ren Kang , Zhang Chencheng , Sun Bomin , Li Dianyou 
Published: January 2022

IntroductionPrevious studies have shown that subthalamic nucleus (STN) and unilateral globus pallidus interna (GPi) are similarly effective in the deep brain stimulation (DBS) treatment of motor symptoms. However, the counterintuitively more common clinical application of STN DBS makes us hypothesize that STN is superior to GPi in the treatment of motor symptoms.MethodsIn this prospective, double-blind, randomized crossover study, idiopathic PD patients treated with combined unilateral STN and contralateral GPi DBS (STN in one brain hemisphere and GPi in the other) for 2 to 3 years were enrolled. The MDS UPDRS-III total score and subscale scores for axial and bilateral limb symptoms were assessed preoperatively and at 2- to 3-year follow-up in four randomized, double-blinded conditions: (1) Med–STN+GPi–, (2) Med–STN–GPi+, (3) Med+STN+GPi–, and (4) Med+STN–GPi+.ResultsEight patients had completed 30 trials of assessment. Compared with the preoperative Med– state, in the Med–STN+GPi– condition, the cardinal symptoms in both sides of the body were all improved. In the Med–STN–GPi+ condition, symptoms of the GPi-stim limb were improved, while only tremor was improved on the ipsilateral side, although all axial symptoms showed aggravation. Compared with the preoperative Med+ state, in the Med+STN+GPi– state, cardinal symptoms were improved on both sides, except that tremor was worsened on the STN-stim side. In the Med+STN–GPi+ state, the overall motor symptoms were aggravated compared with the preoperative Med+ state. Most axial symptoms worsened at acute unilateral STN or GPi DBS onset, compared to both preoperative Med– and Med+ states. No side effects associated with this study were seen.ConclusionsImprovement in motor symptoms was greater in all sub-scores favoring STN. The effects of STN+ were seen on both sides of the body, while GPi+ mainly acted on the contralateral side.
Prognostic Value of Pretreatment Controlling Nutritional Status Score for Patients With Pancreatic Cancer: A Meta-Analysis
Authors: Ma Xiaofeng , Zou Weihua , Sun Yu 
Published: January 2022

BackgroundPrevious studies have explored the prognostic value of the pretreatment Controlling Nutritional Status (CONUT) score of patients with pancreatic cancer. However, the results of those studies were inconsistent. We used meta-analysis to investigate the impact of the CONUT score on the prognosis for patients with pancreatic cancer.MethodsWe thoroughly searched the PubMed, Web of Science, Embase, and Cochrane Library databases for relevant articles from inception to November 19, 2021. Combined hazard ratios (HRs) and 95% confidence intervals (95% CIs) were used to estimate the prognostic value of the CONUT score with respect to survival duration. The pooled odds ratios (ORs) and 95% CIs were used to estimate the correlation between the CONUT score and clinical characteristics.ResultsThe database search found seven studies with 2,294 patients for inclusion in this meta-analysis. A high CONUT score was significantly associated with poor overall survival (OS) (HR = 1.56, 95% CI = 1.13–2.16, p = 0.007), but not with recurrence-free survival (RFS) (HR = 1.47, 95% CI = 0.97–2.23, p = 0.072) of patients with pancreatic cancer. Moreover, there was a significant association between an elevated CONUT score and male patients (OR = 1.34, 95% CI = 1.03–1.75, p = 0.029). However, there was no significant association between the CONUT score and the clinical stage (OR = 1.11, 95% CI = 0.46–2.71, p = 0.576), lymph node metastasis (OR = 0.73, 95% CI = 0.39–1.36, p = 0.323), lymphatic vessel invasion (OR = 0.84, 95% CI = 0.55–1.28, p = 0.411), invasion of the portal vein system (OR = 1.04, 95% CI = 0.51–2.13, p = 0.915), and nerve plexus invasion (OR = 1.22, 95% CI = 0.83–1.80, p = 0.318) in patients with pancreatic cancer.ConclusionsThe results of our meta-analysis indicate that a high CONUT score predicts a poor OS in patients with pancreatic cancer. The CONUT score may be an effective prognostic factor in pancreatic cancer in clinical practice.
Comparison of Conventional DWI, Intravoxel Incoherent Motion Imaging, and Diffusion Kurtosis Imaging in Differentiating Lung Lesions
Authors: Zheng Yu , Li Jie , Chen Kang , Zhang Xiaochun , Sun Huan , Li Shujiao , Zhang Xie , Deng Zhenping , Liang Na , Li Shihong 
Published: January 2022

PurposeTo compare conventional diffusion weighted imaging (DWI), intravoxel incoherent motion imaging (IVIM) and diffusion kurtosis imaging (DKI) in differentiating malignant and benign lung lesions.MethodFifty-five consecutive patients with lung lesions underwent multiple b-value DWI. The apparent diffusion coefficient (ADC), IVIM and DKI parameters were calculated using postprocessing software and compared between the malignant and benign groups. Receiver operating characteristic (ROC) analysis was performed for all parameters.ResultsADC and D were lower in malignant lesions than in benign lesions, while Kapp was higher (P &lt; 0.05). The differences in D*, f, and Dapp between the two groups were not significant (P &gt; 0.05). The areas under the curves (AUCs) of ADC, D, and Kapp were 0.816, 0.864, and 0.822. The combination of all the significant parameters yielded an AUC of 0.880. There were no significant differences in diagnostic efficacy among ADC, D, Kapp and the predictor factor (PRE).ConclusionsIn this study, traditional DWI (ADC), IVIM (D), and DKI (Kapp) all had good diagnostic performance in differentiating malignant lung lesions from benign lesions, but the combination of ADC, D, and Kapp value had better diagnostic efficacy than these parameters alone.
Anti-Remodeling Cardiac Therapy in Patients With Duchenne Muscular Dystrophy, Meta-Analysis Study
Authors: Raccah Bruria Hirsh , Biton Bar , Amir Offer , Gotsman Israel , Nahman Dean , Matok Ilan 
Published: January 2022

Background: Almost all Duchenne muscular dystrophy (DMD) patients that reach their 30s present cardiomyopathy. As a result, this population remains under-treated. There is no sufficient proof of the efficacy of anti-remodeling cardiac therapy for DMD cardiomyopathy (DMDCM). We aim to assess the efficacy of anti-remodeling cardiac therapy for DMDCM by using meta-analysis.Methods: PubMed (MEDLINE), Embase, and Cochrane library were searched through January 2021. Randomized control trials, case-control studies, and observational studies that reported assessments of cardiovascular outcomes and death of participants using angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, mineralocorticoid-receptor antagonists and Ivabradine, were included. The primary outcome was total mortality. Secondary outcomes included changes in left ventricular ejection fraction (LVEF), serum natriuretic peptide levels (BNP), and heart rate (HR). Data were extracted for eligibility by two independent reviewers. Random-effects meta-analysis was used to pool results.Results: Twelve studies with 439 patients were included in our meta-analysis. Treated patients have lower HR, mean difference of −17 beats per minute (CI [−25]–[−9], p &lt; 0.01). The LVEF was improved in treated patients, with a mean difference of LVEF of 3.77% (CI 0.44–7.12, p &lt; 0.03). Although mortality rates did not reach statistical significance there was a trend for total mortality reduction (hazard ratio 0.36, CI (0.1–1.25), p = 0.107) and for BNP reduction (SSMD: 0.141, CI ([−0.19]–[0.47]), p = 0.3).Conclusion: Pharmacologic treatment for DMDCM patients is associated with decreased HR and improved LVEF. Therefore, DMDCM patients may benefit from implementing guideline therapy for HF.
Accumulated Epinephrine Dose is Associated With Acute Kidney Injury Following Resuscitation in Adult Cardiac Arrest Patients
Authors: Gao Qiang , Mok Hsiao-Pei , Qiu Hai-Long , Cen Jianzheng , Chen Jimei , Zhuang Jian 
Published: January 2022

The goal of this study was to investigate the association between total epinephrine dosage during resuscitation and acute kidney injury after return of spontaneous circulation in patients with cardiac arrest. We performed a secondary analysis of previously published data on the resuscitation of cardiac arrest patients. Bivariate, multivariate logistic regression, and subgroup analyses were conducted to investigate the association between total epinephrine dosage during resuscitation and acute kidney injury after return of spontaneous circulation. A total of 312 eligible patients were included. The mean age of the patients was 60.8 ± 15.2 years. More than half of the patients were male (73.4%) and had an out-of-hospital cardiac arrest (61.9%). During resuscitation, 125, 81, and 106 patients received ≤2, 3 - 4, and ≥5 mg epinephrine, respectively. After return of spontaneous circulation, there were 165 patients (52.9%) and 147 patients (47.1%) with and without acute kidney injury, respectively. Both bivariate and multivariate analysis showed a statistically significant association between total epinephrine dosage and acute kidney injury. The subgroup analysis showed that the strength of the association between epinephrine dosage and acute kidney injury varied by location of cardiac arrest. Further multivariate regression analysis found that the association between epinephrine dosage and acute kidney injury was only observed in patients with in-hospital cardiac arrest after adjusting for multiple confounding factors. Compared with in-hospital cardiac arrest patients who received ≤2 mg of epinephrine, patients with 3–4 mg of epinephrine or ≥5 mg of epinephrine had adjusted odds ratios of 4.2 (95% confidence interval 1.0–18.4) and 11.3 (95% confidence interval 2.0–63.0), respectively, to develop acute kidney injury. Therefore, we concluded that a higher epinephrine dosage during resuscitation was associated with an increased incidence of acute kidney injury after return of spontaneous circulation in adult patients with in-hospital cardiac arrest.
Burnout in the Pharmaceutical Activity: The Impact of COVID-19
Authors: Santos Pedro Machado dos , Silva Claudia Ribeiro da , Costa Diana , Torre Carla 
Published: January 2022

ImportancePharmacists are among the healthcare professionals involved in the response to the COVID-19 pandemic, maintaining essential services. In the context of restrictions and reorganization of human resources, as a result of policies recently applied to the health sector, following international guidelines, and given the scarcity of data on burnout in pharmaceutical activity, it was considered highly relevant to promote a nationwide survey aiming to collect more complete evidence on the burnout syndrome and to understand how pharmacists have viewed their work and the people they worked closely with.ObjectivesThe study aimed to assess the occurrence of pharmacist burnout and determine outcomes for each of its dimensions; identify potentially associated characteristics; and determine profiles and critical limits.DesignA cross-sectional observational study conducted by a multidisciplinary panel from the Portuguese Pharmaceutical Society (PPS). Professionals from community and hospital pharmacies who were at the forefront of the COVID-19 response were involved in (i) confirming the need and pertinence for conducting this research, (ii) identifying the main factors leading to pharmaceutical emotional distress (“burnout”), and (iii) disseminating the survey. The questionnaire was designed for digital voluntary, confidential, and anonymous participation and divided into four segments of data collection: (i) demographics, (ii) employment and workplace characterization, (iii) pandemic impact on labor activity, and (iv) burnout assessment (as described ahead).SettingAn electronic survey was addressed to all PPS members, and an account was created solely to manage the questionnaire data for the research team. The web-based and user-friendly platform Google Forms supported the data capture and provided an intuitive interface for validated data entry.ParticipantsIn a population of 15,565 pharmacists (members of the PPS), the minimum recommended sample size (Epi Info software), with a 5% margin of error and a 99.9% confidence interval, should be 1,012 individuals. A total of 1,362 pharmacists participated in the study. Of these, 91.4% (n = 1,246) were involved in direct patient care activity and 7.7% (n = 106) in non-direct patient care activity.
Digital Health Interventions for Mental Health, Substance Use, and Co-occurring Disorders in the Criminal Justice Population: A Scoping Review
Authors: Leach Rebecca , Carreiro Stephanie , Shaffer Paige M. , Gaba Ayorkor , Smelson David 
Published: January 2022

BackgroundSubstance use disorder (SUD), mental health disorders (MHD), and co-occurring mental health and substance use disorders are common among criminal justice populations. Digital health interventions (DHI) represent an opportunity to expand co-occurring disorder treatment for justice involved populations, but efficacy data are lacking.ObjectivesThe current scoping review aims to address this gap via following objectives: (1) Describe trends involving DHIs for MHD, SUD, or co-occurring disorders studied in criminal justice settings; and (2) review available evidence for the impact of DHIs on criminal justice-, substance-, and mental health-related outcomes.MethodsPubMed was searched for relevant articles that met the follow inclusion criteria: (1) focus on criminal justice-involved individuals; (2) description of an intervention focused on SUD, MHD, or co-occurring disorders; and (3) use of DHI. Articles were assessed using standardized data abstraction and quality assessment tools.ResultsFour-hundred unique articles were identified on initial search, and 19 were included in the final review. The most common focus of the intervention was SUDs. The most common modalities were telehealth and computer assisted interventions, with most utilized as an adjunct to treatment as usual. No DHIs used wearable devices, and one included justice involved youth. Feasibility and acceptability were high, and the studies that measured substance and mental health-related outcomes reported equivocal or positive results. No studies focused on long-term justice-related outcomes.ConclusionsLiterature on DHIs for criminal justice involved populations diagnosed with SUD, MHD and co-occurring disorders is limited, and largely focuses on telehealth or eHealth, with less data on mHealth approaches. Future research should focus on the inclusion of diverse populations and include objective monitoring tools.
Changes in the Number of Medal Events, Sport Events, and Classes During the Paralympic Games: A Historical Overview
Authors: Baumgart Julia Kathrin , Blaauw Eline Renee , Mulder Roy , Severin Anna Cecilia 
Published: January 2022

PurposeTo chart how changes in the number of medal events relate to changes in the number of sport events and classes during the Paralympic Games (PG) between 1960 and 2018.MethodsWeb-scraping was used to extract information from the website of the International Paralympic Committee (IPC) on all unique medal events, sport events, and classes per PG, which were then accumulated per sport to descriptively identify and further explore changes.ResultsThe increased number of medal events during the early Summer Games (SG) (1960–1984: 113–975) and Winter Games (WG) (1976–1994: 55–113) was primarily due to an increased number of classes and sport events. While this suggested an increased sports participation among athletes with disabilities, it made the PG difficult to organize. A decrease in the number of medal events subsequently occurred during the SG (1984–1992: 975–489) and WG (1994–2006: 133–58). This was mainly achieved by reducing the number of sport events in the larger sports. Following this decline phase, the number of medal events and sport events has remained relatively stable for both editions of the PG, though this was achieved through different strategies. The WG employed the time-factor system for all individual sports, which enabled competitions across classes within sport events and thus, award a single gold medal (one medal event) for several classes. The SG have maintained the number of medal events despite a slight increase in classes (112–181). This was due to some sports combining classes in the same event, while others excluded certain classes from certain sport events.ConclusionsThe number of medal events during each PG appear to be closely related to the number of sport events and, partially, to the number of classes. The stability in the number of medal events may indicate that a balance has been achieved, where there currently are enough classes and sport events to ensure fairness, while also maintaining a level of prestigiousness for winning a medal. However, it remains to be seen whether this stability will last or if the continued growth of the PG with more athletes and countries will warrant changes in the number of medal events.
PARADIGMA PENDIDIKAN SISTEMIK-ORGANIK: Sebuah Upaya Inovatif Dalam Pendidikan
Authors: Djuwairiyah Djuwairiyah , Muqit Abd. 
Published: January 2022

Education is a necessity of human life. The human educational process life of man, educated, acquired, trained, directed the school system. The education system in schools are expected to be able to make a man who has superior good kognitive, affective , and psychomotor . The maximum ability of student can be formd from an educational institution with systemic - organic paradigm, all components of education make an active role and every function apply and linkages cooperation with the otherÂ function.
Penetration and microstructure of steel joints by ultrasonic-assisted gas metal arc welding
Authors: Chung Vinh Tran-The , Nguyen Thai Cong , Bui Duy Khanh , Nguyen Huu Loc , Van Nguyen Anh , Nguyen Thanh-Hai 
Published: January 2022

Abstract
This work investigates the application of ultrasonic vibration to steel joints formed by gas metal arc welding. Welding is done using a metal active gas welding source with welding current of 120–160 A, 0.8 mm diameter welding wire and 10 l min−1 CO2 flow. The distance from the torch to the ultrasonic horn is 120 mm. Ultrasonic vibration most affects the weld when ultrasonic vibration position is 120 mm from torch and increases the penetration when welding speed is 190 (275) mm/min for a 5 mm thick (10 mm thick) plate. Moreover, weld width increases when welding speed is 190 mm min−1 for 10 mm thick plate. Although ultrasonic vibration does not affect the hardness of welding zones, it modifies the microstructure of the diffusion and welding-pool zones.
Penggunaan Multimedia Pembelajaran Interaktif Materi Pancadhamma Terhadap Minat Belajar Siswa
Authors: Putranto Dwiyono 
Published: January 2022

<p>Minat belajar di SMP N 2 Donorojo cenderuh masih rendah hal ini dapat dilihat dari hasil observasi peneliti pada saat melakanakan tugas PPL (Praktik Pengalaman Lapangan) di SMP N 2 Donorojo, Masalah yang terjadi adalah kurangnya minat dalam belajar pendidikan agama Buddha dari masing-masing siswa. salah satu masalah yang timbul adalah guru dalam menyampaikan bahan pelajaran hanya menggunakan bahasa lisan atau tulisan dan jarang sekali disertai alat pendukung yang lebih konkrit yang dapat memperjelas materi yang disampaikan sehingga kurang adanya minat belajar yang tinggi dari siswa. Peneliti kemudia melakukan penelitian dengan menggunakan multimedia pembelajaran interaktif dalam menyampaikan materi pembelajaran Pancadhamma. Metode yang digunakan dalam penelitian ini adalah metode eksperimen, jumlah sampel yang diambil sebanyak 24 siswa. Instrumen yang digunakan adalah analisis data dilakukan dengan analisis non parametrik teknik t-test.</p><p>Berdasarkan hasil persentase Analisis t-test menunjukkan bahwa Penggunaan media Media Pembelajaran Interaktif Pendidikan Agama Buddha berpengaruh signifikan terhadap Minat Belajar Pendidikan Agama Buddha pada siswa kelas VII SMP N 2 Donorojo. Hal ini terbukti dari hasil statistik paired sample t test yang menunjukkan bahwa nilai Asymp. Sig lebih kecil dibandingkan dengan daftar pada taraf signifikan 5% yaitu 0,000 ≤ 0,03. Selanjutnya, pencapaian Minat belajar juga mempunyai nilai yang baik. Nilai rata-rata pree test atau sebelum perlakuan 58% dengan kategori CUKUP dan setelah diberi perlakuan atau post test meningkat sebesar 70%, Sehingga secara keseluruhan Minat belajar siswa setelah penggunaan Media Pembelajaran Interaktif diperoleh rata-rata sebesar 70% dan termasuk dalam kategori TINGGI.</p>
Eosinophilic Fasciitis with Concurrent Necrobiotic Granulomatous Dermatitis Related to Checkpoint Inhibition Therapy
Authors: Haroon Adeeb , Tadros Joseph , Smith Emily H. 
Published: January 2022

ABSTRACT
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapeutics. However, loss of physiologic tolerance in few cases has triggered rare and novel immune-related adverse events (irAEs). Eosinophilic fasciitis, an infrequently reported diffuse scleroderma-like entity, has been associated with ICI therapy. We report a case of a patient with metastatic melanoma treated with nivolumab who developed eosinophilic fasciitis with concurrent granulomatous dermatitis and lymphadenitis, the latter of which mimicked melanoma recurrence radiographically. Furthermore, this patient had a severe presentation that subsequently proved to be treatment-resistant to both corticosteroid and steroid-sparing therapies. To our knowledge, eosinophilic fasciitis has not been reported concurrently with granulomatous dermatitis in literature. We provide a narrative of this case and a review of therapeutic approaches for severe or refractory irAEs. With the increasing popularity of ICI therapy, we believe it is essential for clinicians to identify novel irAEs and be aware of treatments as late recognition could prove fatal.
Analisis Return on Assets dalam Menilai Pertumbuhan Laba Perusahaan
Authors: Stevani Wike , Nuraidha  
Published: January 2022

This study aims to determine how the Return On Assets in assessing the company. This study uses a qualitative method consisting of two variables, namely Return On Assets as the independent variable and Profit Growth as the dependent variable. The data analysis method used in this research is the analysis of Return On Assets in assessing the company's profit growth. The test results show that the average Return On Assets of 49.39% per year as a whole is categorized as very good, when viewed from the general standard or industry average, which is less than 30%. Based on the results of these studies that Return On Assets in assessing Profit Growth has a contribution of 0.76%. This can be proven by the results of research that each Return On Assets changes by 1 rupiah will be followed by changes in Profit Growth of 0.54 which means that Return On Assets is very significant in assessing Profit Growth.
Abstrak
Penelitian ini bertujuan untuk mengetahui bagaimana Return On Asset dalam menilai Perusahaan. Penelitian ini menggunakan metode kualitatif yang terdiri dari dua variabel yaitu Return On Assets sebagai variabel independen dan Pertumbuhan Laba sebagai variabel dependen. Metode analisis data yang digunakan dalam penelitian ini adalah analisis Return On Assets dalam menilai pertumbuhan laba perusahaan. Hasil pengujian menunjukan bahwa rata-rata Return On Assets sebesar 49,39% pertahun secara keseluruhan dikategorikan sangat baik, bila dilihat dari standar umum atau rata-rata industri yaitu kurang dari 30%. Berdasarkan hasil penelitian tersebut bahwa Return On Assets dalam menilai Pertumbuhan Laba memiliki kontribusi sebesar 0,76%. Hal ini dapat dibuktikan dengan hasil penelitian bahwa setiap Return On Assets mengalami perubahan sebesar 1 rupiah akan diikuti oleh perubahan Pertumbuhan Laba sebesar 0,54 yang berarti sangat signifikan Return On Assets dalam menilai Pertumbuhan Laba.