bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surface Modification of Stereolithography-based 3D Printed Structures Utilizing Ultrasonic-atomised Sprays
Authors: Kanjirakat Anoop , Belaidi Abdelhak , Carvero Arnel , Amani Mahmood , Retnanto Albertus 
Published: December 2022

Abstract

Stereolithography (SLA)-based three-dimensional (3D) printing has become a popular tool for creating experimental models to study the two-phase flow behavior in complex flow structures. The main drawback while implementing such models is the wettability nature of the 3D printed surfaces. As non-geological materials are used while printing the porous designs, the flow mechanics do not follow similar patterns as in the reservoir. This work demonstrates the feasibility of using an SLA-based printing technique to replicate a porous structure. The porosity and pore size values of the 3D print are observed to be very close to that of the porous input image of the rock sample. A simple method to modify the surface characteristics of 3D printed surfaces using an ultrasonic-atomized fine spraying technique is developed. Here a thin layer of CaCO3 is deposited on the 3D printed surface by subjecting it to fine alternate sprays of calcium chloride and sodium carbonate. Thirty cycles of coating is observed to have altered the surface's wettability from neutral to oil-wet, resembling a carbonate reservoir.
Gamma-rays induced genome wide stable mutations in cowpea deciphered through whole genome sequencing
Authors: Punniyamoorthy Dhanasekar , Jegadeesan Souframanien 
Published: December 2022

Abstract

Gamma-rays are the most widely exploited physical mutagen in plant mutation breeding. They are known to be involved in development of more than 60% of global cowpea mutant varieties. Nevertheless, the characteristics of genome wide mutations induced by gamma-rays has not been studied in cowpea (Vigna unguiculata (L.) Walp.). In the present investigation, mutations elicited by gamma-rays in three cowpea mutant lines in M6 generation were characterized through whole-genome sequencing. Gamma-rays induced a relatively higher frequency (91.1%) of single base substitutions (SBSs) with an average transition to transversion ratio (Ti/Tv) of 2.82. A > G transitions including its complementary T > C transitions predominated the transition mutations, while all the four types of transversion mutations were detected with almost equal frequencies (5.6–7.4%). Indels constituted about 9% of the total induced variation wherein small insertions (5.3%) were relatively more prominent than small deletions (3.7%). Among the indels, single base indels and in particular those involving A/T bases showed preponderance, albeit indels of up to five bases were detected in low proportions. Distributed across all 11 chromosomes, only a fraction of SBSs (19.3%) and indels (12.7%) potentially altered the encoded amino-acids/peptides. The inherent mutation rate induced by gamma-rays in cowpea was observed to be in the order of 1.76 x 10− 6 per base pair. Therefore, gamma-rays with greater tendency to induce SBSs and to a lesser extent indels could be efficiently and effectively exploited in cowpea mutation breeding.
A dual-path model: Bridge between heterogeneous environmental regulations and enterprise green innovation——Based on social information processing theory
Authors: Chen Silu , Tian Chenling , Jiang Xia 
Published: December 2022

Abstract

Drawing upon social information processing theory, this article analyzes the impact of two dimensions of environmental regulations (i.e., command-based and market-based) on enterprise green innovation through two different processes: Top Management Team (TMT) harmonious environmental passion climate and TMT environmental performance anxiety climate. Further, this article examined the moderating role of CEO regulatory focus between TMT affective climate and enterprise green innovation. Analyzing questionnaires collected from 184 Chinese firms in the manufacturing industry, we obtain evidence to support our prediction, finding that environmental regulations positively impact enterprise green innovation. Additionally, TMT harmonious environmental passion climate is found to fully mediate the relationship between market-based environmental regulation and enterprise green innovation, while TMT environmental performance anxiety climate is found to partially mediate the relationship between command-based environmental regulation and green innovation. Furthermore, CEO promotion regulatory focus strengthens the positive impact of TMT harmonious environmental passion climate on green innovation, and CEO prevention regulatory focus strengthens the positive impact of TMT environmental performance anxiety climate on green innovation. These findings extend how and when environmental regulations affect enterprise green innovation.
Study on the Effect of Green Financial Policies on Low Carbon Economic Development-Based on Evidence from Green Financial Reform and Innovation Pilot Zone
Authors: Yao Feng ge , Song Ying , Xue Li qing 
Published: December 2022

Abstract
Green finance is key in supporting industries’ green transformation and helping achieve low-carbon economic(LCE) development. This study creates an index of low-carbon economic development with provincial panel data from 2011–2020 and analyzes the enhancement effect of green finance policies (GFP) on low-carbon economic development and mechanism analysis using a synthetic control method (SCM) based on the creation of the first five provinces participating in the national green finance pilot program in 2017 as a nearly natural test. The empirical findings indicate that the implementation of GFP has a considerable beneficial effect on the growth of the LCE of Zhejiang, Jiangxi, Guangdong, and Guizhou. Meanwhile, Xinjiang's level of LCE development is not severely impacted by the pull-up effect, and both the validity and robustness tests are satisfied by all the empirical findings. The results of the mechanism analysis indicate that making a green financial reform and innovation pilot zone can improve the LCE development by improving the pilot zone’s scientific and technological innovation capacity. Finally, the foundation of the pilot zone for green financial reform and innovation, and policy implications for the further development of an LCE are proposed.
The Potential of Ebselen Against Bipolar Disorder: A Perspective on the Interaction
with Inositol Monophosphatase (IMPase)
Authors: Ribaudo Giovanni , Madabeni Andrea , Nogara Pablo Andrei , Pavan Chiara , Bortoli Marco , Rocha Joao Batista Teixeira , Orian Laura 
Published: December 2022

Abstract:
Despite its narrow therapeutic index and the toxicity issues related to renal injuries,
lithium is still a first-line choice for the treatment of mania and for preventing recurrences in
bipolar disorder. Nevertheless, side effects and limited efficacy in some of the cases push the
search for novel tools to ameliorate these conditions, which still represent a social burden, and
great efforts are being made toward the identification of alternative therapeutic options. In this
context, rational drug design, drug repurposing, and computer-aided drug discovery represent
time-saving and efficient strategies to pursue this goal.
Inositol monophosphatase (IMPase) represents the molecular target of lithium which acts as
an uncompetitive inhibitor. In this context, a screening on NIH Clinical Collection of druglike
compounds highlighted the polypharmacological drug ebselen (2-phenyl-1,2-
benzisoselenazol-3(2H)-one) as a non-competitive, irreversible IMPase inhibitor, suggesting that this molecule
could represent a valid therapeutic alternative.
In this perspective article, we aim at providing a historical overview of the uses of ebselen with particular attention
to its potential use as lithium-mimetic. We critically analyse this aspect by investigating in silico the molecular
mechanism leading to the formation of the Se-S bond between IMPase Cys141 and ebselen. Evidence of the bond
formation is supported by the crystallographic data Fenn et al. We hypothesize that the IMPase-ebselen complex
promotes the association with other IMPase chains, improving the formation of the tetramer adduct, suggesting that
ebselen may stabilize the human IMPase in a form that could be less active, resulting in a decreased enzymatic activity.
An Overview of Pharmacological and Clinical Aspects of Spirulina
Authors: Afsari Forough , Zarshenas Mohammad Mehdi , Ansari Ramin , Foroughinia Farzaneh , Dadbakhsh Amir Hossein 
Published: December 2022

Abstract:
Spirulina or Arthrospira, a Cyanobacterium from the class Cyanophyceae, with a wide
range of properties, has been applied for over 400 years. The present study aimed to review available
investigations surrounding the clinical and pharmacological properties of Spirulina that have been carried
out so far. Databases including Scopus, PubMed, Google Scholar, and Web of Science were
searched for relevant literature using the keywords: (Spirulina), (pharmacology), and (clinical). About
130 papers that studied the pharmacological characteristics of Spirulina in animal models, as well as
clinical trials, were selected from the beginning to 29 July 2021. According to this review, antioxidative,
anti-inflammatory, anti-neoplastic, hypolipidemic, antiviral, immunomodulatory, antimicrobial,
anti-atherogenic, anti-diabetic, and radio-protective functions are attributed to Spirulina. Moreover,
Spirulina's positive influence on several organs, including hair, skin, liver, CNS, lung, and genitourinary
tract, are ascribed to different components of various species of Spirulina such as Spirulina
platensis, Spirulina fusiformis, and Spirulina maxima. Although so many studies have been accomplished
on every aspect of Spirulina in recent years, the lack of a comprehensive investigation surrounding
this microalga encouraged us to prepare this paper. Therefore, the present study could be
considered an up-to-date overview of the clinical, pharmacological, and molecular aspects of Spirulina,
resulting in more occupational research on this valuable organism.
Disturbed Sleep is Not Good for the Heart: A Narrative Review
Authors: Patel Meet , Yarlagadda Harshani , Upadhyay Shubekshya , Neupane Ritesh , Qureshi Umer , Raco Joseph D. , Jain Rahul , Jain Rohit 
Published: December 2022

Abstract:
Sleep-related breathing disorders, including obstructive sleep apnea (OSA) and central
sleep apnea (CSA), have a major impact on cardiovascular function. It has shown an association
with hypertension, coronary artery disease, cardiac arrhythmias, sudden cardiac death, and congestive
heart failure (CHF). This review focuses on highlighting the relationship between sleep apnea
and CHF. We discuss the underlying pathophysiology, which involves the mechanical, neurohormonal,
and inflammatory mechanisms; in addition, the similarities and differentiating clinical features
of OSA in patients with CHF and without CHF. We have also discussed several treatment
strategies, including weight loss, continuous positive airway pressure (CPAP), supplemental oxygen
therapy, theophylline, acetazolamide, mandibular advancement device, and hypoglossal nerve
stimulation (HGNS). We conclude that since there are several overlapping clinical features in patients
with OSA with Heart Failure (HF) and without HF, early detection and treatment are crucial
to decrease the risk of HF, coronary artery disease, and stroke.
Fetal Orbital Epidermal Cyst Pre-postnatal Imaging Findings: A Case
Report and Literature Review
Authors: Topaloğlu Ömer Faruk , Durmaz Mehmet Sedat , Yazol Merve , Özer Halil , Koplay Mustafa 
Published: December 2022

Background:
Fetal ultrasonographic evaluation is a routine part of pregnancy follow-up,
and examination of orbital structures is also part of the routine evaluation. Although orbital developmental
anomalies are common in the neonatal period, diagnosis in the intrauterine period is not common.
To our knowledge, three cases with a diagnosis of congenital orbital epidermal cysts have been
reported in the literature, and two of them had fetal imaging findings. In this article, we present the prepostnatal
imaging findings of a case diagnosed with orbital cyst in the fetal period and histopathologically
diagnosed as epidermal cyst in the neonatal period.

Case report:
A 25-year-old woman applied for ultrasonography (USG) examination at 22 weeks of
gestation. A 35x45 mm cystic lesion causing proptosis, without solid component and vascularity, surrounding
the optic nerve and causing its thinning was observed in the left orbit. In fetal magnetic resonance
imaging (MRI), the intraorbital cystic lesion, which was hyperintense on T2W images and hypointense
on T1W images, had no relationship with intracranial structures and no solid component.
The lesion of the patient, followed up with a multidisciplinary approach, was shown similarly with
computed tomography (CT) and magnetic resonance imaging (MRI) in the postnatal period. Subsequently,
the patient underwent globe-sparing surgery, and the pathological diagnosis was made as the
epidermal cyst.

Conclusion:
Orbital epidermal cysts are rarely seen, and detection in the fetal period is even rarer. It
should be considered in the differential diagnosis of orbital cystic lesions that cause proptosis in fetal
and neonatal periods.
Pharmacophore-based Identification of Potential Mutant Isocitrate Dehydrogenases
I/2 Inhibitors: An Explorative Avenue in Cancer Drug Design
Authors: Soliman Mahmoud E.S. , Poonan Preantha , Peters Xylia Q. , Alahmdi Mohamed I. , Abo-Dya Nader E. 
Published: December 2022

Background:
Heterozygous mutations in the cytoplasmic and mitochondrial isoforms of isocitrate dehydrogenase
enzymes 1 and 2 subtypes have been extensively exploited as viable druggable targets, as they decrease the
affinity of isocitrate and higher affinity of D-2-hydroxyglutarate, an oncometabolite.

Objective:
Vorasidenib (AG-881) has recently been reported as a promising dual inhibitor of mutant isocitrate dehydrogenase
1 and 2 with the ability to penetrate the blood-brain barrier towards the treatment of low-grade glioma. In
order to combat drug resistance and toxicity levels, this compelled us to further investigate this substance as a basis for
the creation of potential selective inhibitors of mutant isocitrate dehydrogenases 1 and 2.

Methods:
By employing a wide range of computational techniques, binding moieties of AG-881 that contributed towards
its selective binding to isocitrate dehydrogenase enzymes 1 and 2 were identified and subsequently used to generate
pharmacophore models for the screening of potential inhibitor drugs that were further assessed by their pharmacokinetics
and physicochemical properties.

Results:
AG-881 was identified as the most favorable candidate for isocitrate dehydrogenase enzyme 1, exhibiting a
binding free energy of -28.69 kcal/mol. ZINC93978407 was the most favorable candidatefor isocitrate dehydrogenase
enzyme 2, displaying a strong binding free energy of -27.10 kcal/mol. ZINC9449923 and ZINC93978407 towards
isocitrate dehydrogenase enzyme 1 and 2 showed good protein structural stability with a low radius of gyration values
relative to AG-881.

Conclusion:
We investigated that ZINC9449923 of isocitrate dehydrogenase enzyme 1 and ZINC 93978407 of isocitrate
dehydrogenase enzyme 2 could serve as promising candidates for the treatment of lower-grade glioma as they
cross the blood-brain barrier, and present with lower toxicity levels relative to AG-881.
Effects of Piper sarmentosum on Bone Health and Fracture Healing:
A Scoping Review
Authors: Chin Kok-Yong , Ekeuku Sophia Ogechi , Mohd Ramli Elvy Suhana 
Published: December 2022

Background:
Piper sarmentosum (PS) is a traditional herb used by Southeast Asian communities
to treat various illnesses. Recent pharmacological studies have discovered that PS possesses antioxidant
and anti-inflammatory activities. Since oxidative stress and inflammation are two important processes
driving the pathogenesis of bone loss, PS may have potential therapeutic effects against osteoporosis.

Objective:
This review systematically summarised the therapeutic effects of PS on preventing osteoporosis
and promoting fracture healing.

Methods:
A systematic literature search was performed in November 2021 using 4 electronic databases
and the search string "Piper sarmentosum" AND (bone OR osteoporosis OR osteoblasts OR osteoclasts
OR osteocytes).

Results:
Nine unique articles were identified from the literature. The efficacy of PS has been studied in
animal models of osteoporosis induced by ovariectomy and glucocorticoids, as well as bone fracture models.
PS prevented deterioration of bone histomorphometric indices, improved fracture healing and restored
the biomechanical properties of healed bone in ovariectomised rats. PS also prevented osteoblast/osteocyte
apoptosis, increased bone formation and mineralisation and subsequently improved trabecular bone
microstructures and strength of rats with osteoporosis induced by glucocorticoids. Apart from its antioxidant
and anti-inflammatory activity, PS also suppressed circulating and skeletal expression of corticosterone
and skeletal expression of 11β hydroxysteroid dehydrogenase type 1 but increased the enzyme
activity in the glucocorticoid osteoporosis model. This review also identified several research gaps about
the skeletal effects of PS and suggested future studies to bridge these gaps.

Conclusion:
PS may be of therapeutic benefit to bone health. However, further research is required to
validate this claim.
Optimal Treatment Interval of Viscosupplementation for Osteoarthritic Knee Pain: Real-world Evidence from a Retrospective Study
Authors: Johnston Janice , Muir Jeffrey , Sloniewsky Michael J. 
Published: December 2022

Background:
The evidence supporting multiple courses of viscosupplementation for knee osteoarthritis continues to grow; however, the optimal treatment interval for repeat courses is not well understood. To address this, we compared baseline pain and disability scores in patients returning for subsequent treatment with their prior discharge scores.

Methods:
We retrospectively collected data from patients at 16 rehabilitation clinics who presented for repeated courses of viscosupplementation treatment for knee OA. Primary outcomes were pain (visual analog scale, VAS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores, which were collected following the initial treatment course and compared with scores upon return for treatment. The proportion of patients who fulfilled a minimal clinically important difference in each outcome was calculated.

Results:
61 patients (81 knees) were included in our analysis. After a 6-month treatment interval, no significant differences were noted between post-discharge and returning scores for either VAS (p=0.73) or WOMAC (Pain: p=0.42; Function: p=0.54; Stiffness: p=0.29). Patients waiting 9 months to return for treatment saw a 45% increase in their pain scores (p=0.10) and significant worsening in WOMAC scores (Pain: p=0.007; Function: p=0.03; Stiffness: p=0.04). At 12 months, pain (p=0.01), WOMAC Pain (p=0.05), and WOMAC Stiffness (p=0.02) had all worsened significantly compared to discharge following the initial course.

Conclusion:
Our data indicate that patients who return for treatment within a 6-month treatment interval maintain their improvements, but that when the interval increases to 9 months or more, patients present as significantly worsened, having lost the benefit of their initial course of treatment.
A Comprehensive Review of Indian Market Scenario and Motor used in
Electric Vehicle
Authors: Tiwari Nitesh , Yadav Shekhar , Arya Sabha Raj 
Published: December 2022

Abstract:
This paper focuses on better understanding the Indian Electric Vehicle (EV) market scenario
based on battery and motor specifications. Electric two-wheelers, three-wheelers, and fourwheelers
have different challenges and requirements at the efficient design level. This paper also
provides a comprehensive review of brushed DC motors, brushless DC (BLDC) motors, permanent
magnet synchronous motors (PMSM), induction motors (IM), switched reluctance motors (SRM),
and flux switching motors (FSM) for EV application.

Background:
The market for EVs is growing rapidly in India as a developing country, and users are
looking forward to highly efficient and cost-effective EVs due to the pollution and unavailability of
petroleum.

Objective:
The main objective of this paper is to provide the right choice of EV motor based on vehicle
type, driving cycle, and user requirement.

Method:
This paper comprehensively reviews DC and AC motor drive systems for EV application.

Conclusion:
Nowadays, manufacturing is mainly inclined towards the BLDC, PMSM, and IM. In
contrast, SRM and FSM are in the early stage of development and are mainly used by the researcher.
A brushed DC motor is not too famous due to its high running cost, frequent maintenance requirements,
and comparatively bulky size.
Comparison of Single-Pass Differential Speed Rolling (DSR) and Conventional
Rolling (CR) on the Microstructure and Mechanical Properties of
Mg5Zn
Authors: Xu Zhigang , Hale Christopher , Zhang Honglin , Yarmolenko Sergey , Sankar Jagannathan 
Published: December 2022

Background:
The primary hot rolling method implemented is differential speed rolling
(DSR). The material is rolled and grains are strained, producing fine dynamic recrystallization
(DRX) grains that improve material strength and ductility.

Objective:
The material introduced and under investigation in this paper is an Mg-based alloy,
Mg5Zn (wt. %), whose microstructure is enhanced through a combination of heat treatments with
proper temperature and holding time and subsequent plastic deformation through hot rolling to
evaluate the effect on mechanical properties

Methods:
The method involves preheating the material to various temperatures in a range from
250ºC to 350ºC and rolling to various thickness reductions to analyze the effect of single-pass differential
speed rolling (DSR) and conventional rolling (CR) on the DRX process and its influence
on mechanical properties.

Results:
The effect of single-pass differential speed rolling (DSR) and conventional rolling (CR)
on the DRX process shows that the process produces increasing amounts of finer DRX grains at
higher rolling reductions, thereby improving the strength and ductility of the material.

Conclusion:
This investigation demonstrated that single-pass DSR can improve the mechanical
properties and formability of Mg5Zn more effectively than CR in terms of grain refinement analyzed
through OM, SEM, and EBSD resulting in enhanced tensile strength and ductility [1].