bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hans Haacke et la logique culturelle du postmodernisme
Authors: Jameson Fredric , Boidy Maxime 
Published: October 2022

Initialement publié en 1986, l’article « Hans Haacke et la logique culturelle du postmodernisme » de Fredric Jameson, ici traduit par Maxime Boidy, questionne l’autonomie de l’art et des institutions à l’ère contemporaine à travers le travail de l’artiste Hans Haacke, mis en relation avec les notions de « postmodernité » et de « critique institutionnelle » propres à l’auteur américain. Selon Jameson, l’œuvre de Hans Haacke est révélatrice d’un changement de paradigme. L’autonomie de l’art et celle des institutions n’existent plus car toutes deux répondent aux exigences d’un nouveau marché. Il n’est plus question d’analyser ou d’accepter une œuvre sous le prisme de l’« esthétique », ni de la classe sociale de l’artiste et des spectateurs – qui était alors bien définie – mais sous celui d’un art de masse, capitaliste, doté de nouvelles pratiques et constitué de praticiens et spectateurs issus d’une pluralité de microgroupes. Hans Haacke, toujours selon Jameson, exacerbe ce contexte dans son œuvre par l’utilisation, presque à outrance, des codes de ce nouveau marché qui substitue à l aquestion de l’autonomie celle de la « totalisation ».
L’autre robotique
Authors: Grangier Emmanuelle 
Published: October 2022

Dans notre société industrielle, les robots sont déjà omniprésents : ils nous assistent quotidiennement bien que nous ne les intégrons pas encore pleinement à notre espace, les limitant à occuper des marges bien définies. Pourtant, de par son impact économique et relationnel, la robotique bouleverse notre rapport au travail, à notre environnement social et à notre propre corps. Cette critique, extension d’un langage chorégraphique et performatif, invite à reconsidérer les comportements et les interactions inter-humains mais aussi (voire surtout) entre les humains et leurs machines. Émerge alors quelque chose qui échappe à ces deux interlocuteurs, des accidents et des improvisations qui enrichissent leurs programmes, leurs codes et leurs manières de se mettre en scène.
Langue nouée / langue déliée
Authors: Belhadi Yasmine 
Published: October 2022

L’artiste franco-gabonaise Myriam Mihindou invite le spectateur à se réapproprier la langue française dans sa série De la langue secouée. En partant du postulat que le langage est un outil d’oppression et de domination qui s’attaque aux corps autant qu’aux psychés, l’artiste démantèle l’étymologie des mots pour en laisser voir la mémoire. Son analyse étymologique du langage s’accompagne d’une analyse de la structure même des mots visant à déconstruire les considérations racistes et sexistes. Comme les pionnières de la Négritude avant elle, la plasticienne rend compte des états d’aliénation des corps blessés par le français : c’est par cette même langue que l’artiste entreprend un mouvement politique de décolonisation du langage.
Les relations entre soignants et soignés sans-abri à Strasbourg : entre négociation, adaptation mutuelle et conflits ouverts
Authors: Coulomb Laureline 
Published: October 2022

Après quelques temps passés dans la rue, les personnes sans-abri développent des logiques d’action particulières qui découlent de leur besoin de survivre dehors. Ces conditions de vie aboutissent généralement à un état de santé très dégradé. Pourtant, on observe des situations de refus de soins, où la personne sans-domicile explique ne pas vouloir consulter de médecin ou se rendre à l’hôpital, voire même où elle s’oppose aux soins qui lui sont proposés et dont elle aurait besoin. Parallèlement, il se produit parfois qu’une personne sans-abri soit renvoyée de l’hôpital ou du cabinet médical, souvent pour des raisons de manque d’hygiène, de comportement agressif ou inadapté, alors qu’elle cherchait à s’y faire soigner.L’analyse des interactions entre personnels de santé et soignés sans-domicile met en évidence que les logiques d’action de ces deux groupes sont très éloignées. Leurs valeurs divergent également : ils n’ont pas le même rapport au corps, à la santé et au pathologique, ce qui produit d’importants malentendus et de nombreuses incompréhensions.Pourtant, ils mettent en place des compromis, grâce à des adaptations mutuelles et des négociations constantes. Le personnel de santé recherche une relation basée sur la confiance, tout en gardant une certaine distance afin que chacun soit protégé au cours de ses interactions. Les soignés acceptent ainsi plus facilement de dévoiler leurs souffrances, leurs difficultés, leurs corps. Les soignants, quant à eux, s’impliquent moins personnellement dans les échanges, en endossant le rôle de médecin ou d’infirmier.Ils réussissent ainsi à supporter les souffrances auxquelles ils doivent faire face. Les vulnérabilités respectives de ces deux groupes sont importantes. Elles sont à l’origine des situations extrêmes évoquées plus haut. Les négociations, compromis et adaptations mutuelles sont autant de moyens d’atteindre une meilleure prise en charge médicale.
Investigation of Soft Impacts in Elements of Pipe Robots
Authors: RAGULSKIS Kazimieras , SPRUOGIS Bronislovas , BOGDEVIČIUS Marijonas , MATULIAUSKAS Arvydas , MIŠTINAS Vygantas , RAGULSKIS Liutauras 
Published: October 2022

Vibrators with deformable impact support under harmonic excitation are especially useful in the case when their stationary regimes of motion are stable. This is useful in practice by applying those vibrators to single direction manipulators and various robots of space type.
For practical application it is necessary to reveal dynamical qualities of the system from where it would be possible to determine optimal regimes. For this purpose investigations of dynamics of the system by numerical methods were performed.
Investigation of dynamics of impact interactions in elements of robots is an important engineering problem. Dynamics of soft impacts in elements of manipulators and robots is investigated. The model of the investigated system is described. Numerical investigations for various parameters of the system are performed. Free and forced vibrations are investigated.
From the presented results it can be noted that for the smaller values of the coefficient of stiffness of the support period of steady state motion coincides with the period of the exciting force, while for the higher values of the coefficient of stiffness of the support period of steady state motion is equal to two periods of the exciting force. Thus it is concluded that with the increase of the coefficient of stiffness of the support behavior of the investigated vibro impact system with soft impacts experiences essential changes.
Main characteristics of steady state motion as functions of frequency of excitation are investigated. From the presented results the minimum and maximum inter impact intervals as functions of frequency of excitation, minimum and maximum velocities before impact as functions of frequency of excitation, minimum and maximum minimum displacements in inter impact intervals as functions of frequency of excitation are seen. Three resonant zones of expected single valued motions are observed in the presented results. They correspond to optimal regions of operation of the vibro impact system with soft impacts.
Results of the performed analysis of dynamic interactions with soft impacts in the elements of manipulators and robots are used in the process of design of pipe robots of advanced type.
The Acceleration of Digital Maturity during the COVID-19 Pandemic in the Retail Industry in Sri Lanka
Authors: Hemachandra Sankhani , Sharkasi Nora 
Published: October 2022

The recent saying is that COVID-19 pandemic had the most exerted influence in the world after the Second World War. Developing countries, such as Sri Lanka, are no exception. The pandemic brought various digital initiatives to cope with limitations that lead to a much-accelerated digital transformation. The retail sector continued to undergo digital transformation in Sri Lanka with a particular focus on advancing the customer experience by digitally creating, delivering, and capturing value. We interviewed top management in various areas in the retail industry in Sri Lanka and followed a hybrid research methodology for analysis combining the grounded theory and the framework-based approach. We described the gap between the focus of the literature’s digital maturity models in the past 10 years and the top management’s needs throughout the accelerated digital transformation during the pandemic as follows: the difference in the percentage of the expression of common dimensions in digital transformation and maturity models and the percentage of the expression of dimensions in the managers’ interviews. Our findings call for the attention of academic research to dedicate more attention to further integrate more dimensions related to technology, cloud and data, digital marketing, and products into the digital transformation and maturity models.
Who is in the sample? An analysis of real and surrogate users as participants in user study research in the information technology fields
Authors: Salminen Joni , Jung Soon-gyo , Kamel Ahmed , Froneman Willemien , Jansen Bernard J. 
Published: October 2022

Background
Constructing a sample of real users as participants in user studies is considered by most researchers to be vital for the validity, usefulness, and applicability of research findings. However, how often user studies reported in information technology academic literature sample real users or surrogate users is unknown. Therefore, it is uncertain whether or not the use of surrogate users in place of real users is a widespread problem within user study practice.

Objective
To determine how often user studies reported in peer-reviewed information technology literature sample real users or surrogate users as participants.

Method
We analyzed 725 user studies reported in 628 peer-reviewed articles published from 2013 through 2021 in 233 unique conference and journal outlets, retrieved from the ACM Digital Library, IEEE Xplore, and Web of Science archives. To study the sample selection choices, we categorized each study as generic (i.e., users are from the general population) or targeted (i.e., users are from a specific subpopulation), and the sampled study participants as real users (i.e., from the study population) or surrogate users (i.e., other than real users).

Results
Our analysis of all 725 user studies shows that roughly two-thirds (75.4%) sampled real users. However, of the targeted studies, only around half (58.4%) sampled real users. Of the targeted studies sampling surrogate users, the majority (69.7%) used students, around one-in-four (23.6%) sampled through crowdsourcing, and the remaining 6.7% of studies used researchers or did not specify who the participants were.

Conclusions
Key findings are as follows: (a) the state of sampling real users in information technology research has substantial room for improvement for targeted studies; (b) researchers often do not explicitly characterize their study participants in adequate detail, which is probably the most disconcerting finding; and (c) suggestions are provided for recruiting real users, which may be challenging for researchers.

Implications
The results imply a need for standard guidelines for reporting the types of users sampled for a user study. We provide a template for reporting user study sampling with examples.
Computational study of potential inhibitors for fat mass and obesity-associated protein from seaweed and plant compounds
Authors: Prabhakar Lavanya , Davis G Dicky John 
Published: October 2022

Background
Over the past three decades, with substantial changes in lifestyle, the tendency to gain weight has increased, which is resulting in significant consequences affecting an individual’s well-being. The fat mass and obesity-associated (FTO) gene is involved in food intake and energy expenditure and plays a crucial role in regulating homeostasis and controlling energy expenditure by hindering signals that generate from the brain. Edible seaweeds have been shown to enhance satiety owing to their health benefits.

Methods
Extensive screening of plant-derived anti-obesity compounds and seaweed compounds was conducted and validated for ADME properties and toxicity prediction. Further, the top ranked compounds were docked against the FTO protein to identify potential inhibitors and were subjected to molecular dynamic simulation studies to understand the binding stability of ligand protein complex. Finally, MM/PBSA studies were performed to calculate the binding free energy of the protein-ligand complexes.

Results
Through the virtual screening of 1,210 compounds, 443 compounds showed good docking scores less than −7.00 kcal/mol. Drug likeness screenings of 443 compounds showed that only 369 compounds were in accordance with these properties. Further toxicity prediction resulted in 30 non-toxic compounds. Molecular docking studies revealed four top ranked marine compounds. Finally, RL074 (2-hydroxyluzofuranone B) and RL442 (10-acetoxyangasiol) from marine red alga Laurencia sp showed good stability from molecular dynamic simulation studies. MM/PBSA results revealed that BT012 (24ε-hydroperoxy-6β-hydroxy-24-ethylcholesta-4,-28(29)-dien-3-one), an oxygenated fucosterol from brown alga Turbinaria conoides, possessed higher binding energy. Hence, with all the data obtained it could be concluded that three seaweed compounds, BT012, RL074 and RL442, may act as a potential anti-obesity lead compound in targeting FTO.
Effect of a Novel Brief Motivational Intervention for Alcohol-Intoxicated Young Adults in the Emergency Department
Authors: Gaume Jacques , Bertholet Nicolas , McCambridge Jim , Magill Molly , Adam Angéline , Hugli Olivier , Daeppen Jean-Bernard 
Published: October 2022

ImportanceHeavy drinking among young adults is a major public health concern. Brief motivational interventions in the emergency department have shown promising but inconsistent results.ObjectiveTo test whether young adults receiving a newly developed brief motivational intervention reduce their number of heavy drinking days and alcohol-related problems over 1 year compared with participants receiving brief advice.Design, Setting, and ParticipantsThis randomized clinical trial was conducted at an emergency department of a tertiary care university hospital in Lausanne, Switzerland. Recruitment ran from December 2016 to August 2019. Follow-up was conducted after 1, 3, 6, and 12 months. All adults aged 18 to 35 years presenting for any cause and presenting with alcohol intoxication were eligible (N = 2108); 1764 were excluded or refused participation. Follow-up rate was 79% at 12 months and 89% of participants provided follow-up data at least once and were included in the primary analyses. Statistical analysis was performed from September 2020 to January 2021.InterventionsThe novel intervention was based on motivational interviewing and comprised in-person discussion in the emergency department and up to 3 booster telephone calls. The control group received brief advice.Main Outcomes and MeasuresPrimary outcomes were the number of heavy drinking days (at least 60 g of ethanol) over the previous month and the total score on the Short Inventory of Problems (0-45, higher scores indicating more problems) over the previous 3 months. Hypotheses tested were formulated before data collection.ResultsThere were 344 young adults included (median [IQR] age: 23 [20-28] years; 84 women [24.4%]). Among the 306 participants providing at least 1 follow-up point, a statistically significant time × group interaction was observed (β = −0.03; 95% CI, −0.05 to 0.00;P = .02), and simple slopes indicated an increase of heavy drinking days over time in the control (β = 0.04; 95% CI, 0.02 to 0.05;P &amp;lt; .001) but not in the intervention group (β = 0.01; 95% CI, −0.01 to 0.03;P = .24). There was no effect on the Short Inventory of Problems score (β = −0.01; 95% CI, −0.03 to 0.02;P = .71).Conclusions and RelevanceThis randomized clinical trial found that a brief motivational intervention implemented in the emergency department provided beneficial effects on heavy drinking, which accounts for a substantial portion of mortality and disease burden among young adults.Trial RegistrationISRCTN registry:13832949
Perspectives of Historically Black College and University Advisors to Premedical Students During the COVID-19 Pandemic
Authors: Weiss Jasmine , Holaday Louisa , Keene Danya , Akingbesote Ngozi D. , Balasuriya Lilanthi , Sharifi Mona , Latimore Darin , Genao Inginia 
Published: October 2022

ImportanceBlack students remain underrepresented in medicine despite national efforts to increase diversity in the physician workforce. Historically Black College and University (HBCU) students play a vital role in increasing representation in the workforce. Currently, there is a paucity of literature understanding the impact of COVID-19 on premedical students from HBCUs. Understanding the adverse impact of the pandemic on HBCU students is essential to inform strategies that promote holistic medical school admissions and increased diversity, equity, and inclusion in the medical workforce.ObjectiveTo explore premedical advisors' perspectives on the impact of the COVID-19 pandemic on HBCU premedical students pursuing admission to medical school.Design, Setting, and ParticipantsIn this qualitative study, semistructured interviews of HBCU premedical advisors were performed from March 2020 to March 2021. One-on-one interviews were conducted with 21 advisors with a depth of experience as advisors, varied educational backgrounds, and diverse geographic representation. Data analysis was performed from March 2021 to December 2021.Main Outcomes and MeasuresThe experiences of HBCU premedical students during the COVID-19 pandemic from the perspective of the premedical advisor.ResultsAmong the 21 participants, 13 (62%) were female, 15 (71%) were Black or African American, 11 (52%) had a doctorate degree, and 7 (33%) had more than 10 years of experience as advisors. Participants described 3 major themes: (1) balancing academic responsibilities with family demands; (2) distraction, disruption, and isolation in the virtual learning environment; and (3) harmful impact of new stressors for HBCU applicants in the medical school admissions process.Conclusions and RelevanceIn this qualitative study of HBCU advisors to premedical students, advisors described how the COVID-19 pandemic adversely affected undergraduate HBCU premedical students; students faced family hardships, challenges with virtual learning, and uncertainty in the medical school admissions process. These findings suggest that medical schools should continue to create direct interventions to address the challenges that HBCU students faced during the height of the pandemic and as longitudinal consequences of the pandemic. Addressing these issues may improve physician workforce representation and promote more equitable patient care for underserved communities disproportionately affected by COVID-19 and other health disparities.
Cancer Stem Cells
Authors: Bushnell Grace G. , Brooks Michael D. , Wicha Max S. 
Published: October 2022

Overview
There is substantial evidence that many, if not most, tumors contain a subpopulation of cells that display stem cell properties. These “cancer stem cells” (CSC) play an important role in tumor initiation and propagation. Furthermore, these cells may mediate metastasis and resistance to cancer therapeutic agents and therefore play a fundamental role in cancer relapse. This highlights the importance of developing therapeutic approaches to target this cell population. In this article, we will review current thoughts on the role of tissue stem cells in carcinogenesis and the pathways that regulate the plasticity and heterogeneity of these cells. We will then review clinical implications of CSC in dormancy and metastasis and current efforts to therapeutically target these cells.
Cancer and Cell Death
Authors: Reed John C. 
Published: October 2022

Overview
Cell death is a normal facet of human physiology, ensuring tissue homeostasis by offsetting cell production with cell demise. Neoplasms arise in part because of defects in physiological cell death mechanisms, contributing to pathological cell expansion when genetic or epigenetic alternations impart a selective survival advantage to premalignant or malignant cells. Defects in normal cell death pathways also contribute to cancer progression by permitting progressively aberrant cell behaviors, while also desensitizing tumor cells to immune‐mediated attack, radiation, and chemotherapy. Multiple mechanisms have been identified that account for dysregulation of cell death mechanisms in human malignancies, providing insights into cancer pathogenesis and providing targets for therapeutic intervention based on the concept of restoring sensitivity to natural pathways for triggering cell suicide. Moreover, the extensive overlap of components of the cell death machinery with responses to pathogens has been implicated in tumor immunity mechanisms.
Systems Biology and Genomics
Authors: Hassan Saima , Gray Joe W. , Heiser Laura M. 
Published: October 2022

Overview
Cancers are complex, adaptive systems comprised of cancer cells that are influenced by supporting cells, immune cells, as well as soluble and insoluble proteins that make up the local physical environment. Features associated with cancer cells are referred to as intrinsic to the cancer and those comprising the proximal and distal microenvironments are referred to as extrinsic to the cancer. Genomics studies seek to develop comprehensive cellular and molecular profiles of cancers while cancer systems biology studies seek to develop the experimental and theoretical methods needed to understand how these diverse components work together to determine cancer function. The overall goal of these efforts is to develop analytical approaches to predict cancer behavior—including progression and response to therapy—from measurements of the intrinsic and extrinsic molecular and cellular components of tumors. Here, we review recent progress in international efforts to measure the genomic, epigenomic, and proteomic features of major tumor types. We summarize work to establish associations between these omic features and cancer behavior including risk of progression and response to therapy. Finally, we summarize the computational and experimental models employed to understand and manipulate the behavior of complex cancer systems.
Ultraviolet Radiation Carcinogenesis
Authors: Cleaver James E. , Ortiz‐Urda Susana , Arron Sarah 
Published: October 2022

Overview
Skin carcinogenesis from solar UV exposure is initiated by UV photoproducts formed in the DNA of precursor cells that give rise to squamous cell carcinomas (SCC), basal cell carcinomas (BCC), and cutaneous malignant melanomas (CMM). SCC and BCC are caused by UVB but CMM by reactive oxygen generated through UVA absorption in melanin. The UVB photoproducts consist of dimers between adjacent pyrimidines that are repaired by nucleotide excision repair (NER). Two branches of NER differ in mechanisms of damage recognition: in global genome repair (GGR) damage is recognized in nontranscribed DNA by the DDB2 and XPC proteins; in transcription‐coupled repair (TCR) damage is recognized by arrest of the transcribing RNA polymerase at damaged sites. The T = C photoproduct is the predominant mutagenic product which, if unrepaired, gives rise to C to T or CC to TT mutations through replication by the low fidelity polymerase Pol H. TCR reduces the mutation frequency in regions of transcription. Deficiencies in GGR in the human disease xeroderma pigmentosum cause earlier onset and increased rates of skin cancer. Deficiencies in TCR in the human disease Cockayne syndrome are associated with photosensitivity, developmental and neurological disorders, but no cancer has been reported.