bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial perception mediated by insect antennal mechanosensory system
Authors: Ifere Nwuneke Okereke , Shidara Hisashi , Sato Nodoka , Ogawa Hiroto 
Published: January 2022

ABSTRACT
Animals perceive their surroundings using various modalities of sensory inputs to guide their locomotion. Nocturnal insects such as crickets use mechanosensory inputs mediated by their antennae to orient in darkness. Spatial information is acquired via voluntary antennal contacts with surrounding objects, but it remains unclear whether the insects modulate behaviors mediated by other sensory organs based on that information. Crickets exhibit escape behavior in response to a short air puff, which is detected by the abdominal mechanosensory organs called cerci and is perceived as a ‘predator approach’ signal. We placed objects of different shapes at different locations with which the cricket actively made contact using its antennae. We then examined the effects on wind-elicited escape behavior. The crickets changed their movement trajectory in response to nearby objects such as walls so that they could avoid collision with these obstacles even during the cercal-mediated behavior. For instance, when a wall was placed in front of the crickets so that it was detected by one antenna, the escape trajectory in response to a stimulus from behind was significantly biased toward the side opposite the wall. Even when the antenna on the free side without the wall was ablated, this collision avoidance was also observed, suggesting that the mechanosensory inputs from one antennae detecting an object edge would be sufficient to perceive the location of obstacle in front. This study demonstrated that crickets were able to use the spatial information acquired with their antennal system to modify their behavior mediated by other sensory organs.
Evaluation of the potential benefits of iron supplementation in organic pig farming
Authors: Prunier Armelle , Pauwels Maud , Leblanc-Maridor Mily , Jaillardon Laetitia , Belloc Catherine , Merlot Elodie 
Published: January 2022

Background: Iron from the stock acquired during foetal life and the ingestion of milk is not sufficient to cover the needs of the piglets during their first weeks of life. In organic farming, systematic supplementation with iron is problematic due to a strong limitation in pharmaceutic treatments. Methods: Erythroid parameters around weaning were measured in piglets from organic outdoor and indoor farms, and related to indicators of the inflammatory status. Blood samples were collected from 28.9±2.6 piglets/herd at 42.0±3.2 days of age and 11.9±3.0 kg live weight (mean ± SD) in 21 farms from the west part of France. Among the 11 outdoor farms, only one had supplemented piglets with 200 mg iron while among the 10 indoor farms, only one had not supplemented piglets, one had supplemented them with 100 mg, 8 with 200 mg and one with 400 mg. Results: Compared to outdoor piglets without supplementation, piglets kept indoors and receiving 200 mg iron had lower haemoglobin concentration (105 vs 118±2 g/l, mean ± SE) and red blood cell volume (56 vs 60±1 fl) (P<0.005). The reduction in haemoglobin concentration and red blood cell volume was more pronounced in indoor piglets supplemented with 100 mg of iron and even more when they had not received iron. The plasma concentration of haptoglobin was lower in outdoor than in indoor piglets (0.51±0.06 vs 0.78±0.09 g/l) whereas no effect of housing was observed for markers of oxidative stress (dROM, BAP). In the 14 farms where sow parity was known, the haemoglobin concentration was lower in piglets from primiparous than from multiparous sows (109 versus 114±2 g/l, P < 0.001). Conclusion: With the exception of soils where the content of bioavailable iron is very low, piglets from outdoor farms do not require iron supplementation, unlike those raised indoors.
Exact Approaches for Single Machine Total Weighted Tardiness Batch Scheduling
Authors: Pessoa Artur Alves , Bulhões Teobaldo , Nesello Vitor , Subramanian Anand 
Published: January 2022

This paper addresses a single machine total weighted tardiness (TWT) batch-scheduling problem in which jobs have release dates, nonidentical sizes, and are compatible between each other. We propose two integer linear programming models: the first one is a time-indexed formulation (TIF), and the second is an innovative time-size-indexed formulation (TSIF). Although TIF clearly outperforms the existing formulation for the problem, TSIF is capable of producing much stronger bounds in practice. The latter also enables us to develop an efficient column-generation (CG) algorithm. The pricing subproblem corresponds to a resource-constrained shortest path problem that is solved using a bucket graph–based labeling algorithm. The solutions of such a subproblem may contain cycles (reprocessing of jobs), and thus, a memory mechanism called dynamic arc-based ng-sets is employed in the labeling with a view toward avoiding some of them. Moreover, we also implement a preprocessing scheme based on Lagrangian relaxation to perform variable fixing. Extensive computational experiments were carried out in 810 benchmark instances. The proposed CG algorithm is capable of solving instances with up to 100 jobs to optimality. In addition, we believe that this is the first exact approach for a TWT batch-scheduling variant capable of systematically solving instances with up to 50 jobs. High-quality results are also reported for three special cases of the problem—more precisely, when (i) the penalty weights are unitary, (ii) there are no release dates, and (iii) all due dates are set to zero and, hence, the objective becomes equivalent to minimizing the weighted completion time. Summary of Contribution: This paper provides the first exact algorithm for a standard variant of a batch-scheduling total weighted tardiness problem that can solve instances with up to 100 jobs to optimality, a considerable leap with respect to previous works. In particular, we propose a time-indexed formulation that has the advantage of being relatively simple to implement, and yet we show that it is not theoretically dominated by the other innovative formulation proposed in the paper referred to as the time-size-indexed formulation (TSIF). Moreover, we present a Lagrangian approach to quickly fix variables and an iterative column-generation (CG) procedure over a Dantzig–Wolfe decomposition of TSIF that combines an efficient pricing algorithm with a dynamic scheme to adjust the subproblem constraints. The proposed CG approach is capable of producing very strong bounds for the problem as well as for some of its special cases.
Information Accessibility and Corporate Innovation
Authors: Kong Dongmin , Lin Chen , Wei Lai , Zhang Jian 
Published: January 2022

This study identifies information accessibility as a determinant of corporate innovation. Using the sudden termination of Google’s search services in China, we find a persistently large negative effect on the intensity and quality of innovation among firms relying on foreign knowledge. The results are stronger for firms in industries dominated by foreign technology, in regions with local web filters, and for firms with fewer alternative sources of foreign information. We also find that the affected firms cite fewer foreign patents and their innovation efficiency declines after Google’s exit. Overall, the results are consistent with the view that access to information is an important driver of technological progress. This paper was accepted by Kay Giesecke, finance. Funding: D. Kong acknowledges financial support from the National Natural Science Foundation of China [Grants 71802160, 71991473, and 71772178] and the Major Project of National Social Science Foundation of China [Grant 21ZDA010]. C. Lin acknowledges financial support from the National Natural Science Foundation of China [Grant 71790601]. L. Wei acknowledges financial support from the Research Grant Council of the Hong Kong Special Administrative Region, China [Project T35/710/20R]. J. Zhang acknowledges financial support fromthe PRC Ministry of Education Youth Project for Humanities and Social Science Research [Grant 18XJC630008]. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2021.4224 .
Association between sagittal spinopelvic alignment and femoral head destruction in the early stage of rapidly destructive coxopathy
Authors: Onishi Eijiro , Ota Satoshi , Fujita Satoshi , Tsukamoto Yoshihiro , Yamashita Shinnosuke , Hashimura Takumi , Matsunaga Kazuhiro , Yasuda Tadashi 
Published: January 2022

Aims This study aimed to evaluate sagittal spinopelvic alignment (SSPA) in the early stage of rapidly destructive coxopathy (RDC) compared with hip osteoarthritis (HOA), and to identify risk factors of SSPA for destruction of the femoral head within 12 months after the disease onset. Methods This study enrolled 34 RDC patients with joint space narrowing > 2 mm within 12 months after the onset of hip pain and 25 HOA patients showing femoral head destruction. Sharp angle was measured for acetabular coverage evaluation. Femoral head collapse ratio was calculated for assessment of the extent of femoral head collapse by RDC. The following parameters of SSPA were evaluated using the whole spinopelvic radiograph: pelvic tilt (PT), sacral slope (SS), pelvic incidence (PI), sagittal vertical axis (SVA), thoracic kyphosis angle (TK), lumbar lordosis angle (LL), and PI-LL. Results The HOA group showed higher Sharp angles compared with the RDC group. PT and PI-LL were higher in the RDC group than the HOA group. SS and LL were lower in the RDC group than the HOA group. No difference was found in PI, SVA, or TK between the groups. Femoral head collapse ratio was associated with PT, SS, SVA, LL, and PI-LL. A PI-LL > 20° and a PT > 30° correlated with greater extent of femoral head destruction by RDC. From regression analysis, SS and SVA were significantly associated with the femoral head collapse ratio within 12 months after disease onset. Conclusion Compared with HOA, RDC in the early stage correlated with sagittal spinopelvic malalignment. SS and SVA may partially contribute to the extent of femoral head destruction by RDC within 12 months after the onset of hip pain. The present study indicates a potential role of SSPA assessment in identification of RDC patients at risk for subsequent bone destruction. Cite this article: Bone Jt Open 2022;3(1):77–84.
CardiOvascular examination in awake Orangutans (Pongo pygmaeus pygmaeus): Low-stress Echocardiography including Speckle Tracking imaging (the COOLEST method)
Authors: Chetboul Valérie , Concordet Didier , Tissier Renaud , Vonfeld Irène , Poissonnier Camille , Alvarado Maria Paz , Passavin Peggy , Gluntz Mathilde , Lefort Solène , Bourgeois Aude , Duby Dylan , Hano Christelle , Chai Norin 
Published: January 2022

Introduction
Cardiovascular diseases have been identified as a major cause of mortality and morbidity in Borneo orangutans (Pongo pygmaeus pygmaeus). Transthoracic echocardiography is usually performed under anesthesia in great apes, which may be stressful and increase risks of peri-anesthetic complications in case of cardiac alteration. The aim of the present pilot study was hence to develop a quick and non-stressful echocardiographic method (i.e., the COOLEST method) in awake Borneo orangutans (CardiOvascular examination in awake Orangutans: Low-stress Echocardiography including Speckle Tracking imaging) and assess the variability of corresponding variables.

Materials and methods
Four adult Borneo orangutans trained to present their chest to the trainers were involved. A total of 96 TTE examinations were performed on 4 different days by a trained observer examining each orangutan 6 times per day. Each examination included four two-dimensional views, with offline assessment of 28 variables (i.e., two-dimensional (n = 12), M-mode and anatomic M-mode (n = 6), Doppler (n = 7), and speckle tracking imaging (n = 3)), representing a total of 2,688 measurements. A general linear model was used to determine the within-day and between-day coefficients of variation.

Results
Mean±SD (minimum-maximum) images acquisition duration was 3.8±1.6 minutes (1.3–6.3). All within-day and between-day coefficients of variation but one (n = 55/56, 98%) were <15%, and most (51/56, 91%) were <10% including those of speckle tracking systolic strain variables (2.7% to 5.4%).

Discussion
Heart morphology as well as global and regional myocardial function can be assessed in awake orangutans with good to excellent repeatability and reproducibility.

Conclusions
This non-stressful method may be used for longitudinal cardiac follow-up in awake orangutans.
COVID-19 infection prevention practices among a sample of food handlers of food and drink establishments in Ethiopia
Authors: Andualem Atsedemariam , Tegegne Belachew , Ademe Sewunet , Natnael Tarikuwa , Berihun Gete , Abebe Masresha , Alemnew Yeshiwork , Mulu Alemebante , Mezemir Yordanos , Melaku Abayneh , Addis Taffere , Belay Emaway , Walle Zebader , Kumlachew Lake , Teym Abraham , Adane Metadel 
Published: January 2022

Background
Cases of coronavirus disease (COVID-19) are increasing at an alarming rate throughout the world, including Ethiopia. Food handlers in food and drink establishments are at high risk of exposure to the virus due to their many daily contacts with customers. Since there is a paucity of evidence about infection prevention practices and associated factors among this high-risk group in Ethiopia including in Dessie City and Kombolcha Town, this study was designed to address this gap.

Method
An institution-based cross-sectional study was conducted among 422 food handlers in Dessie City and Kombolcha Town food and drink establishments in July and August 2020. The study participants were selected using a simple random sampling technique. Data were collected by trained data collectors using a pretested structured questionnaire and an on-the-spot observational checklist. Data were entered into EpiData version 4.6 and exported to STATA version 14.0 for data cleaning and analysis. Data were analyzed using bivariable and multivariable logistic regression model at 95% confidence interval (CI). From the bivariable analysis, variables with a p-value <0.25 were retained into multivariable analysis. Finally, variables that had a p-value <0.05 were declared as factors significantly associated with good infection prevention practices of COVID-19 among food handlers.

Main findings
The overall rate of good practice in infection prevention among food handlers was 43.9% (95% CI: 39.2–48.4%). Among the total 401 food handlers, 79.8% had good knowledge and 58.4% had a favorable attitude about COVID-19 infection prevention. Factors significantly associated with good COVID-19 infection prevention practices were: educational status of college or above (AOR = 1.97; 95% CI: 1.32–3.75), food handling work experience greater than five years (AOR = 2.55; 95% CI: 1.43–5.77), availability of written guidelines within the food and drink establishment (AOR = 2.68; 95% CI: 1.52–4.75), and taking training about infection prevention (AOR = 3.26; 95% CI: 1.61–6.61).

Conclusion
Our findings showed that around one-third of food handlers had good infection prevention practices. Thus, to reduce COVID-19 transmission, integrated work is urgently needed to further improve food handlers’ good practices, knowledge and attitude about infection prevention through providing health education, training and by making written infection prevention guidelines available in food and drink establishments.
Understanding pharmaceutical care and nurse prescribing in Spain: A grounded theory approach through healthcare professionals’ views and expectations
Authors: Lillo-Crespo Manuel , Riquelme-Galindo Jorge , De Baetselier Elyne , Van Rompaey Bart , Dilles Tinne 
Published: January 2022

Background
Pharmaceutical care has been implemented and regulated differently across Europe with no consensus among countries in relation with professional competencies and especially on nurse prescribing. Demophac Project funded by the European Commission aims to develop a Pan-European Pharmaceutical Care Model with collaboration of 14 partner teams across Europe including Spain where nurse prescribing is starting its implementation at regional level. The aim of the study was to increase understanding of the role of nurses in Pharmaceutical care in Spain after the Nurse Prescribing Regulation approved in 2018 throughout exploring the views and expectations of health professionals involved in the representative settings.

Methods and findings
In depth interviews were conducted in a structure previously agreed by the European Demophac partnership around four topics associated with the Nursing ideal role in pharmaceutical care and the ideal interaction with other healthcare professionals. A grounded-theory approach based on Corbin & Strauss was conducted to interpret collected data from the Spanish most representative settings (primary care, specialized care and residential care for older population). Participants were health professionals involved in pharmaceutical care that accepted to participate (nurses (n = 7), physicians (n = 8) and pharmacists (n = 9)). A pharmaceutical care comprehensive model for the Spanish context considering the recently approved Nurse Prescribing role and the interprofessional collaboration and communication was developed towards facilitating the understanding in such context and the contribution to the unified European Demophac Framework.

Conclusions
Nurses are primarily responsible for population’s Pharmaceutical Care while other professionals pivot on them to provide quality healthcare on a multidisciplinary level. Nurse prescribing may contribute efficiently to the Spanish Health System though more consensus in terms of nurses’ training nationwide and enhancement in communication among different professionals within healthcare organizations is required to achieve adequate integrated care into practice.
Peripheral mitochondrial DNA, telomere length and DNA methylation as predictors of live birth in in vitro fertilization cycles
Authors: Li Piani Letizia , Reschini Marco , Somigliana Edgardo , Ferrari Stefania , Busnelli Andrea , Viganò Paola , Favero Chiara , Albetti Benedetta , Hoxha Mirjam , Bollati Valentina 
Published: January 2022

Objective
To evaluate whether telomere length (TL), mitochondrial-DNA (mt-DNA) or epigenetic age estimators based on DNA methylation (DNAm) pattern could be considered reliable predictors of in-vitro-fertilization (IVF) success in terms of live birth rate.

Design
Prospective cohort study

Setting
Infertility Unit of the Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico

Patients
181 women aged 37–39 years who underwent IVF at a single-centre between January 2017 and December 2018.

Interventions
On the day of recruitment, blood samples were collected, and genomic DNA was isolated from white blood cells. TL, mt-DNA and DNAm assessment was performed using quantitative real-time polymerase chain reaction (qPCR). Biological age (DNAm age) was computed as the algorithm based on methylation pattern of five genes. Epigenetic age acceleration was estimated from the residuals of the linear model of epigenetic age regressed on chronological age. Long Interspersed Nuclear Elements (LINE)-1 methylation pattern was used as a surrogate for global DNA methylation.

Main outcome measures
This study investigated whether peripheral TL, mt-DNA and DNAm could predict live birth in IVF cycles.

Results
TL, mt-DNA and LINE-1 methylation were not associated with IVF success. Conversely, DNAm age resulted significantly lower in women who had a live birth compared to women who did not (36.1 ± 4.2 and 37.3 ± 3.3 years, respectively, p = 0.04). For DNAm age, odds ratio (OR) for live birth per year of age was 0.90 (95%CI: 0.82–0.99, p = 0.036) after adjusting for FSH and antral follicle count (AFC) and 0.90 (95%CI: 0.82–0.99, p = 0.028) after adjusting also for number of oocytes retrieved. A significant association also emerged for epigenetic age acceleration after adjustments (OR = 0.91, 95%CI: 0.83–1.00, p = 0.048).

Conclusion
DNAm age is associated with IVF success but the magnitude of this association is insufficient to claim a clinical use. However, our findings are promising and warrant further investigation. Assessment of biological age using different epigenetic clocks or focusing on different tissues may reveal new predictors of IVF success.
Absolute magnitudes of white dwarfs and discovery of new white dwarfs from FBS Blue Stellar Objects by means of Gaia EDR3 data
Authors: Mickaelian Areg M. , Mikayelyan Gor A. , Abrahamyan Hayk V. , Paronyan Gurgen M. , Malkov Oleg Yu. 
Published: January 2022

Abstract
This article is a presentation of a project which is a statistical study of white dwarfs’ properties carried out based on the sample of the First Byurakan Survey Blue Stellar Objects (FBS BSOs) and the Catalogue of White Dwarfs. Using these results, we have searched and will continue to search for new white dwarfs by means of Gaia accurate astrometry. The discovery and study of new White Dwarfs (WDs) is extremely important for understanding the kinematics and dynamics of the local stellar population. They are evolutionary signatures of the Milky Way, as most of stars pass through this evolutionary stage. We have carried out a statistical analysis of the White Dwarfs Catalogue to establish their average physical properties. Based on these data, we have searched for new WDs using Gaia EDR3 accurate astrometry. It provides huge amount of data to confirm WDs and reveal many more such objects. Gaia’s astrometric accuracy allows more detailed studies of WDs and many other stars. Using Gaia accurate data in combination with SDSS and DFBS low-dispersion spectra and additional multiwavelength data, we have revealed many new WDs. Many of them are subject for studies on binarity and variability (including a number of subtypes, e.g. ZZ Ceti stars (pulsating WDs), cataclysmic variables, etc.). WDs among FBS blue stellar objects at high galactic latitudes have been searched and revealed. Search for high galactic latitude WDs in DFBS have also been carried out. Using the revealed and calculated characteristics, a statistical study of WD properties is being done.
Probing the rotation rate of solar active regions: the comparison of methods
Authors: Kutsenko Alexander S. , Abramenko Valentina I. 
Published: January 2022

Abstract
Sunspot groups are often used as tracers to probe the differential rotation of the Sun. However, the results on the rotation rate variation obtained by different authors are not always in agreement. The reason for this might be a number of effects. In particular, faster decay of the following part of a sunspot group results in a false apparent shift of the area-weighted center of the group toward the leading part. In this work we analyze how significantly this effect may contribute to the derived rotation rate. For a set of 670 active regions, we compare the rotation rate derived from continuum intensity images to that derived from line-of-sight magnetograms. We found that the difference between the calculated rotation rates is 0.45° day−1 on average. This value is comparable to the difference between the rotation rate of the solar surface near the equator and at 30° latitude. We conclude that the accuracy of the rotation rate measurements using white-light images is not satisfactory. Magnetograms should be used in future research on the differential rotation of the Sun.