bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of m1A modification genes polymorphisms with glioma risk in Chinese children Running head: m1A genes polymorphisms and glioma risk
Authors: Liao Fan , Hua Rui-Xi , Jia Xingyu , Liao Yuxiang , Yuan Li , Ruan Jichen , Li Tianfeng , Zhuo Zhenjian , He Jing 
Published: November 2022

Abstract
Background
Glioma is a highly heterogeneous malignancy with a high mortality rate, poor prognosis. m1A is an RNA methylation modification that plays a vital role in determining cell fate and cell cycle regulation, and cancer development. However, whether single nucleotide polymorphisms (SNPs) of m1A modification genes are associated with glioma risk is unclear.
Methods
We recruited 314 pediatric glioma patients and 380 cancer-free controls from China and genotyped 20 SNPs of m1A modification genes TRMT10C, TRMT61B, TRMT6, TRM61, ALKBH1, YTHDC1, YTHDF1, and YTHDF2 by TaqMan method. The association of polymorphisms with glioma risk was assessed by the odds ratios (ORs) and 95% confidence intervals (CIs) generated by logistic regression models. Stratified analysis was performed by age, gender, tumor subtype, and clinical stage.
Results
The results showed that TRMT10C rs2303476, TRMT10C rs4257518, TRM61rs2296484, YTHDF2 rs3738067 polymorphisms, and carriage of 2-4 risk genotypes (rs7641261 CT/TT, rs2303476 TC/CC, rs4257518 GG, and rs3762735 GG) were significantly associated with increased risk of glioma, TRMT61Brs4563180, YTHDC1 rs2293595, YTHDC1 rs3813832 polymorphisms and carrying 1-3 protective genotypes (rs2293596 CC, rs2293595 TC/CC, and rs3813832 TC/ CC) were significantly associated with reduced risk of glioma. In addition, analysis of the expression quantitative trait locus showed that TRM61rs2296484 T genotype significantly increased TRM61 mRNA expression, YTHDF2rs3738067 G genotype significantly increased YTHDF2 mRNA expression, and TRMT61B rs4563180 C genotype significantly decreased TRMT61B mRNA expression.
Conclusions
Overall, we identified several promising candidates for m1A modification gene polymorphisms as biomarkers of glioma risk.
Strong-coupled Co0.85 Se/rGO composite as high-efficient electrocatalyst for oxygen evolution
Authors: Feng Zhongbao , Ren Lili , Liu Yanting , Gao Bo 
Published: November 2022

Abstract
Designing high performance oxygen evolution reaction (OER) electrocatalyst is critical for water electrolysis. In this work, a self-supported nanoporous structured Co0.85Se/rGO was prepared on Ni foam (NF) during electrodeposition. The combination of Co0.85Se and rGO can significantly increase electronic conductivity and electrochemically active sites of Co0.85Se/rGO than Co0.85Se and NF. Co0.85Se/rGO shows a low overpotential of 274 mV to afford a high current density of 100 mA cm− 2, a small Tafel slope of 26.5 mV dec− 1, a high durability of 93.6% at a high current density of 100 mA cm− 2 after 24 h test for OER, which is at top level among Co-Se based catalyst that recently reported. The reason for the excellent stability of Co0.85Se/rGO is investigated, mainly attributed to the well maintained nanoporous structure, nearly unchanged electrochemically active surface area (ECSA) and its superaerophobic nature.
Controversies Around COVID-19 Vaccines and Antidepressants: Scope
and Perspective in Malaysia
Authors: Chong Guan Ng , Weng Hou Siew , Abousheishaa Aya Ahmed , Sue Yin Low , bin Sulaiman Abdul Rasyid , Chee Khin Kok 
Published: November 2022

Background:
Individuals with severe mental illness are prone to severe COVID-19
infection with increased morbidity and mortality. Psychiatric patients are often concerned about
the potential interactions between the newly approved COVID-19 vaccines in Malaysia and
psychotropic drugs like antidepressants. To date, such data are unavailable.

Objectives:
This review aims to clear the polemics of COVID-19 vaccine-antidepressants
interaction in these 3 aspects: (1) cytokines and cytochrome P450 pathway, (2) blood-brain barrier
(BBB) involvement and (3) and its interaction with polyethylene glycol (PEG), the potential
allergenic culprit following COVID-19 vaccination.

Methods:
A scoping approach was employed to search for peer-reviewed journal articles across
four healthcare and scientific databases (PubMed, MEDLINE, PsycINFO and Cumulative Index to
Nursing and Allied Health Literature (CINAHL)).

Results:
Antidepressants metabolism often involves the CYP450 enzymes. Vaccine-antidepressants
interactions are probable, likely to be triggered by interactions of CYP450 enzymes and
inflammatory cytokines, resulting in diminished drug metabolism and chemical detoxification.
Aside, PEG, the excipient in mRNA-based COVID-19 vaccines and antidepressants, has been
reported as an anaphylaxis causative allergen. However, whether it leads to synergistic,
potentiation or antagonistic effects when used in combination remains to be elucidated.

Conclusion:
Psychotropic medications, including antidepressants, showed potentially relevant
safety risks for COVID-19 patients. These vulnerable patient group must be prioritized for early
access to safe and efficacious COVID-19 vaccines, as vaccination remains the most important
public health intervention to tackle the ongoing COVID-19 pandemic.
Matched Endoscopic Sleeve Gastroplasty and Laparoscopic Sleeve Gastrectomy Cases: Formative Cohort Study
Authors: Marshall Skye , G Rich Graeme , Cohen Felicity , Soni Asha , Isenring Elizabeth 
Published: November 2022

Background
Bariatric weight-loss surgery rates are increasing internationally. Endoscopic sleeve gastroplasty (ESG) is a novel, minimally invasive endoscopic procedure thought to mimic some of the effects of a more common surgery, laparoscopic sleeve gastrectomy (LSG). Patient factors affecting procedural choice are unexplored.

Objective
This formative study aimed to determine the preoperative and early postoperative characteristics of adults matched for age, sex, and BMI who chose ESG versus LSG.

Methods
This prospective cohort study recruited ESG and matched LSG adults in Australia. Preoperative outcomes were medical history, glycemic biomarkers, blood lipids, liver function enzymes, albumin, blood pressure, hepatic steatosis index, the Gastrointestinal Symptom Rating Scale, the Impact of Weight on Quality of Life–Lite questionnaire, and body composition via dual-energy x-ray absorptiometry. Adverse events were recorded preoperatively and up to 2 weeks postoperatively. SPSS was used to test if there were differences between cohorts by comparing means or mean ranks, and binary regression was used to understand how characteristics might predict procedure choice.

Results
A total of 50 (including 25 ESG and 25 LSG) patients were recruited, who were primarily White (45/50, 90%) and female (41/50, 82%) with a mean age of 41.7 (SD 9.4) years. Participants had a mean of 4.0 (SD 2.2) active comorbid conditions, with the most common being nonalcoholic fatty liver disease (38/50, 76%), back pain (32/50, 64%), anxiety or depression (24/50, 48%), and joint pain (23/50, 46%). The LSG cohort had higher hemoglobin A1c (5.3%, SD 0.2%) than the ESG cohort (5%, SD 0.2%; P=.008). There was a 2.4 kg/m2 difference in median BMI (P=.03) between the groups, but fat and fat-free mass had no meaningful differences. Comparing the LSG and ESG groups showed that the LSG group had lower total quality of life (49.5%, SD 10.6% vs 56.6%, SD 12.7%; P=.045), lower weight-related self-esteem (10.7%, IQR 3.6%-25% vs 25%, IQR 17.9%-39.3%; P=.02), and worse abdominal pain (38.9%, IQR 33.3%-50% vs 53.9%, SD 14.2%, P=.01). For every percent improvement in weight-related self-esteem, the odds for selecting ESG increased by 4.4% (95% CI 1.004-1.085; P=.03). For every percent worsening in hunger pain, the odds for selecting ESG decreased by 3.3% (95% CI 0.944-0.990; P=.004).

Conclusions
There was very little evidence that Australian adults who chose an endoscopic versus surgical sleeve had different rates of comorbidities, body fat percentage, or weight-related quality of life. There was evidence against the test hypothesis, that is, there was evidence suggesting that lower self-esteem predicted choosing a more invasive sleeve (ie, LSG rather than ESG)

Trial Registration
Australia New Zealand Clinical Trials Registry ACTRN12618000337279; https://anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374595
Efficacy of the Mental Health App Intellect to Reduce Stress: Randomized Controlled Trial With a 1-Month Follow-up
Authors: Toh Sean Han Yang , Tan Jessalin Hui Yan , Kosasih Feodora Roxanne , Sündermann Oliver 
Published: November 2022

Background
Excessive stress is a major global health concern, particularly in young adults. Short skills-focused self-guided interventions (SGIs) on smartphones are a scalable way to improve stress-coping skills at the population level.

Objective
In this randomized controlled trial, we aimed to examine the possible efficacy of a recently developed stress-coping SGI (Intellect) in improving psychological distress, relative to an active control group and 2 potential moderators of this predicted relationship (ie, psychological mindedness [PM] and coping self-efficacy [CSE]).

Methods
University students (N=321) were randomly assigned to either an 8-day SGI on stress-coping or an active control group. Self-reported measures were obtained at baseline, after the intervention, and at the 1-month follow-up. The primary outcome was psychological stress (Psychological Stress Measure-9). Secondary outcomes were anxiety (Generalized Anxiety Disorder-7) and depressive symptoms (Patient Health Questionnaire-9). PM and CSE were assessed as potential moderators at baseline.

Results
The final sample (n=264) included 188 (71.2%) female, 66 (25%) male, 7 (2.7%) nonbinary, and 3 (1.1%) others participants with a mean age of 22.5 (SD 5.41) years. The intervention group reported significantly lower perceived stress (partial eta–squared [ηp2]=0.018; P=.03) and anxiety (ηp2=0.019; P=.03) levels after intervention relative to the active control group. The effects on perceived stress levels remained statistically significant at the 1-month follow-up (ηp2=0.015; P=.05). Students with the lowest CSE and highest PM experienced the fastest decline in perceived stress levels (β=6.37, 95% Cl 2.98-9.75). Improvements in anxiety levels were not observed at 1-month follow-up. Similarly, no intervention effects were found for depression levels at postintervention and follow-up periods.

Conclusions
This study provides evidence that the Intellect stress-coping SGI is effective in reducing perceived stress and anxiety levels among university students. Mobile health apps are brief, scalable, and can make important contributions to public mental health.

Trial Registration
ClinicalTrials.gov NCT04978896; https://www.clinicaltrials.gov/ct2/show/NCT04978896
Virtual Reality Therapy for People With Epilepsy and Related Anxiety: Protocol for a 3-Phase Pilot Clinical Trial
Authors: Gray Hannah Gabrielle , Tchao Danielle , Lewis-Fung Samantha , Pardini Susanna , Harris Laurence R , Appel Lora 
Published: November 2022

Background
Anxiety is one of the most common psychiatric comorbidities in people with epilepsy and often involves fears specifically related to the condition, such as anxiety related to the fear of having another seizure. These epilepsy- or seizure-related fears have been reported as being more disabling than the seizures themselves and significantly impact quality of life. Although research has suggested that exposure therapy (ET) is helpful in decreasing anxiety in people with epilepsy, no research to our knowledge has been conducted on ET in people with epilepsy using virtual reality (VR). The use of novel technologies such as an immersive VR head-mounted display for ET in this population offers several benefits. Indeed, using VR can increase accessibility for people with epilepsy with transportation barriers (eg, those who live outside urban centers or who have a suspended driver’s license owing to their condition), among other advantages. In the present research protocol, we describe the design of an innovative VR-ET program administered in the home that focuses on decreasing anxiety in people with epilepsy, specifically anxiety related to their epilepsy or seizures.

Objective
Our primary objective is to examine the feasibility of the study protocol and proposed treatment as well as identify suggestions for improvement when designing subsequent larger clinical trials. Our secondary objective is to evaluate whether VR-ET is effective in decreasing anxiety in a pilot study. We hypothesize that levels of anxiety in people with epilepsy will decrease from using VR-ET.

Methods
This mixed methods study comprises 3 phases. Phase 1 involves engaging with those with lived experience through a web-based questionnaire to validate assumptions about anxiety in people with epilepsy. Phase 2 involves filming videos using a 360° camera for the VR-ET intervention (likely consisting of 3 sets of scenes, each with 3 intensity levels) based on the epilepsy- and seizure-related fears most commonly reported in the phase 1 questionnaire. Finally, phase 3 involves evaluating the at-home VR-ET intervention and study methods using a series of validated scales, as well as semistructured interviews.

Results
This pilot study was funded in November 2021. Data collection for phase 1 was completed as of August 7, 2022, and had a final sample of 18 participants.

Conclusions
Our findings will add to the limited body of knowledge on anxiety in people with epilepsy and the use of VR in this population. We anticipate that the insights gained from this study will lay the foundation for a novel and accessible VR intervention for this underrecognized and undertreated comorbidity in people with epilepsy.

Trial Registration
ClinicalTrials.gov NCT05296057; https://clinicaltrials.gov/ct2/show/NCT05296057

International Registered Report Identifier (IRRID)
DERR1-10.2196/41523
EWING SARCOMA FAMILY OF TUMORS OF SCAPULA IN CHILDREN
Authors: Živanović Dragoljub , Marjanović Zoran 
Published: November 2022

Ewing’s sarcoma (ES) is the second most common malignant bone tumor accounting for 5-10% of malignancies in childhood. The scapula is rarely affected and only several reports have been published. Early symptoms of Ewing’s sarcoma of the scapula may be ignored by patients or misinterpreted by physicians, leading to a delay in diagnosis. In the retrospective analysis, we identified 3 patients (2 males) with Ewing’s sarcoma of scapula, aged 11 -14½ years in a 15-year period. The introduction of combined treatment with multimodal chemotherapy, surgical resection and/or radiation therapy has improved the survival of patients with Ewing’s sarcoma significantly. Several options for resection of ES of scapula were described with generally unfavorable functional results. Two patients were treated with chemotherapy and resection of the scapula. The third patient is on chemotherapy. Two patients died after 2½ and 4 years. In children and adolescents presenting with shoulder pain, Ewing’s sarcoma must be ruled out.
Validation of Relationship between Patients’ Descriptions of Pruritus and Patient-burden of Chronic Pruritus using Structural Equation Modelling
Authors: Ryoo Ji Hoon , Lee Seon Hwa , Ha Dae-Lyong , Park Kyung Duck , Rho Jaehee , Park Gyeong-Hun , Kim Byung-Soo , Li Kapsok , Park Chang Ook , Kim Hye One , Kim Hei Sung , Jang Min Soo , Lee Dong Hun , Lee Yang Won , Kim Do Won , Jang Yong Hyun , Kim Seong-Jin 
Published: November 2022

Patients with chronic itch describe their pruritus in a wide variety of ways. However, these subjective descriptions are often not taken into consideration by physicians. This study aimed to validate patients’ descriptions of pruritus, and to investigate the relationship between various descriptions of pruritus and the patient burden of chronic pruritus by examining the mediating effects of sleep disturbance and sexual dysfunction on patient’s quality of life, as predicted by various descriptions of pruritus. Exploratory and confirmatory factor analyses were performed to identify the factor structure measured by 11 descriptions of pruritus. The study then analysed differences in the degree of sleep disturbance, sexual dysfunction, and quality of life deterioration factors using a structural equation modelling method. Using data from 419 patients with chronic pruritus, 11 descriptions of pruritus were classified into 2 groups: (i) sensory pruritus (i.e. stinging, stabbing, burning, painful, formication, throbbing, and cold) that are linked with descriptions of pruritus patterns; and (ii) affective pruritus (i.e. annoying, unbearable, worrisome, and warm) from patient reports of psychological or emotional distress. The study found that affective pruritus decreases patient’s quality of life either directly or indirectly through sleep disturbance. In conclusion, clues about a patients’ sleep disturbance or poor quality of life can be obtained through their descriptions of pruritus.
The Sound World of Christmas in George Crumb’s Work “A Little Suite For Christmas”
Authors: Сухарукова Е.А. 
Published: November 2022

«Маленькая Рождественская сюита» для фортепиано Джорджа Крама, согласно авторскому подзаголовку, написана «по рождественским фрескам Джотто в Капелле дель Арена в Падуе» (Капелла Скровеньи). Фрески Джотто, одно из величайших творений итальянского мастера, покрывают все внутреннее пространство капеллы, создавая поразительный по красоте и гармонии ансамбль. Музыка «Маленькой Рождественской сюиты» связана с живописью Джотто многими нитями — обращением к сюжетам фресок «Посещение», «Поклонение волхвов», «Избиение младенцев», близкими смысловыми мотивами (праздничная колокольность, мистериальность, молитвенное созерцание), образно-эмоциональными параллелями. Каждая из семи пьес сюиты представляет собой целостное явление, определенное состояние. Торжественные благовещенские звоны, тихая колыбельная, восторженный танец, размеренные шаги волхвов — всё это складывается в стройный цикл, чему способствуют гармонические, фактурные, интонационные связи между пьесами, а также особые инструментальные приемы. Звуковой мир Рождества воплощается в фортепианной сюите средствами характерных для индивидуального стиля Крама расширенных техник исполнения. Пиццикато и глиссандо на струнах фортепиано, обертоновые и педальные эффекты, игра посредством беззвучно нажатых клавишей — эти и другие приемы, всякий раз направленные на достижение определенного образа, создают удивительную звуковую картину, своим колоритом и настроением вызывающую живые ассоциации с фресками Джотто в Капелле дель Арена.
According to the author's title “A Little Suite For Christmas” for piano by George Crumb was based «on Giotto's Nativity frescoes in the Arena Capel at Padua» (Scrovegni Chapel). Giotto's frescoes are one of the greatest masterpieces of the Italian master, they cover the entire interior space of the chapel, creating a gorgeous ensemble of beauty and harmony. The music of the “Little Suite For Christmas” is connected with Giotto's painting by many threads, appealing to such subjects of the frescoes as “Visitation”, “Adoration of the Magi”, “Beating of Babies”, introducing close semantic motives (festive bell-ringing, mystery, devotional contemplation), figurative and emotional parallels. Each of the seven pieces of the suite represents an integral phenomenon, a certain state. Solemn Annunciation bells, a quiet lullaby, an enthusiastic dance, measured steps of the Magi — all this adds up into a harmonious cycle, which is due to harmonic, textured, intonation connections between the pieces, as well as special instrumental techniques. The sound world of Christmas is embodied in the piano suite by means of extended performance techniques characteristic for Crumb's individual style. Pizzicato and glissando on piano strings, harmonics and pedal effects, playing through soundlessly pressed keys — these and other techniques aimed at achieving a certain image create an amazing sound picture, and in combination with color and mood, evoke live associations with Giotto's frescoes in the Capella del Arena.
The Third Concerto of Sergei Rachmaninoff in the Light of the Ideas of Boris Asafyev
Authors: Шаталова А.А. 
Published: November 2022

В статье рассматриваются устойчивые принципы жанровой модели инструментального концерта, представленные в работах разных авторов (Б. В. Асафьев, И. П. Дабаева, М. Е. Тараканов). На примере анализа Третьего концерта для фортепиано и оркестра С. В. Рахманинова в статье показаны идеи Асафьева относительно понятий «концерт», «концертность». По отношению к последнему, исследователь отмечал его значимость в эволюции музыкального мышления композитора. По мнению Асафьева, концертность была основанием для формирования «диалектики из диалога». В связи с этим особое внимание автора статьи сосредотачивается на воплощении принципа диалогичности в музыке композитора. Опираясь на аналитические очерки Асафьева о Втором концерте, симфонических опусах Рахманинова, правомерно говорить о доминирующей роли этого принципа, характерного, в частности, для жанровой модели концерта. Полученные в ходе исследования Третьего концерта результаты можно применять при выявлении специфических признаков стиля музыкального языка композитора, в том числе — специфики оркестрового письма, композиционных решений, интонационных, ладовых, гармонических и фактурных особенностей, своеобразия драматургического развития.
The article discusses sustainable principles of the genre model of the instrumental concerto presented in the works of various authors (Boris Asafyev, Irina Dabaeva, Mikhail Tarakanov etc.). The example of the Third Concerto for Piano and Orchestra by Sergei Rachmaninoff, is used to demonstrate Asafyev’s ideas regarding the concepts of “concerto”, “concerto character”. With reference to the latter, the researcher noted its importance in the evolution of musical thinking. According to Asafyev, the concerto character was the basis for formation of the “dialogue based dialectic”. In this regard, the author of the article focuses on implementation of the principle of dialogue in the composer's music. Based on Asafyev's analytical essays on the Second Concerto, Rachmaninoff 's symphonic opuses, one can speak of the dominant role of this principle, which is characteristic, in particular, for the genre model of the concerto. The results of the research of the Third Concerto, can be used to identify specific features of the style of the composer's musical language, including the mastery of orchestral writing, compositional solutions, intonational, modal, harmonic and textural features, and the originality of the dramatic development.