bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penyuluhan Kebutuhan Dasar Ibu Bersalin
Authors: Fathony Zaiyidah , I Mirawati , Ramdhaniah Nuru , Rahmah4 Alina 
Published: December 2022

ABSTRAK Pendahuluan: Persalinan merupakan suatu hal fisiologis yang dialami oleh setiap ibu bersalin dan suatu hal yang menakjubkan bagi ibu dan keluarga. Namun persalinan juga menjadi saat yang menegangkan dan dapat menggugah emosi ibu dan keluarganya atau bahkan menakutkan bagi ibu. Upaya untuk mengatasi gangguan emosional dan pengalaman yang menegangkan tersebut sebaiknya dilakukan melalui asuhan sayang ibu selama persalinan dan proses kelahiran bayinya.Tujuan: Kegiatan pengabdian masyarakat berupa penyuluhan ini bertujuan untuk meningkatkan pengetahuan dan pemahaman ibu tentang kebutuhan dasar ibu bersalin.Metode: Kegiatan dimulai dengan perkenalan dan penjelasan tujuan kegiatan. Kemudian peserta diberikan soal pre test untuk mengetahui pemahaman peserta tentang kebutuhan dasar ibu bersalin. Selanjutnya peserta diberikan penyuluhan dengan cermah, tanya jawab dan diskusi. Setelah itu dilanjutkan dengan senam hamil. Pada sesi terakhir, peserta diberikan soal post test dengan pertanyaan yang sama dengan pre test untuk dilakukan penilaian terhadap peningkatan pengetahuan ibu.Hasil: rerata nilai post test peserta penyuluhan (88,9) lebih tinggi dibandingkan nilai pre test penyuluhan (66,7). Hasil post test yang dilakukan oleh peserta menunjukkan materi dapat diterima oleh peserta dengan baik.Kesimpulan: Perlu pemberian edukasi atau penyuluhan secara terus-menerus tentang kebutuhan dasar ibu bersalin yang dapat dilaksanakan dalam kelas ibu hamil. Kata kunci: kebutuhan dasar, ibu bersalin, kelas ibu hamil
Produksi Biogas dari Kotoran Sapi dengan Biodigester Kontinyu dan Batch: Review
Authors: Shitophyta Lukhi Mulia , Darmawan Masreza Hari , Rusfidiantoni Yestri 
Published: December 2022

Sumber energi terbarukan perlu terus dikembangkan untuk menekan ketersediaan bahan bakar fosil yang sudah semakin menipis. Biogas merupakan salah satu energi alternatif dengan memanfaatkan limbah organik seperti kotoran sapi. Pengolahan kotoran sapi sebagai bahan baku biogas dapat menggunakan biodigester tipe kontinyu dan tipe batch. Biodigester kontinyu selalu berisi 80% umpan dari volume total (50 liter) dan 20% sisanya sebagai ruang gas. Biodigester tipe batch kapasitas 220 liter memiliki komposisi kotoran sapi dan rumput gajah sebesar 25 kg : 25 kg dengan penambahan air 100 liter. Produksi biogas dilakukan selama 70 hari. Hasil penelitian menunjukkan bahwa biodigester kontinyu menghasilkan volume biogas total 17.520 ml dan kandungan CH4 51,37%, sedangkan untuk biodigester batch menghasilkan volume biogas total 66.484 ml dan kandungan CH4 31,37%. Uji nyala untuk biodigester kontinyu menunjukkan bahwa setelah hari ke-12 nyala api berwarna biru dan menyembur cukup kuat pada saat katup pengaturan gas dibuka dan dikenakan api, tetapi pada biodigester batch tidak menghasilkan nyala api karena kadar CH4 kurang dari 45%. Biodigester tipe kontinyu dengan kapasitas 50 L menghasilkan volume biogas lebih tinggi dibandingkan dengan tipe batch yang berkapasitas 220 liter
Analisis Kemampuan Serapan CO2 dan Simpanan Karbon Pada Hutan Mangrove Di Desa Parida Kecamatan Lasalepa Kabupaten Muna
Authors: Siwi La Ode , Basrudin Basrudin , Kandari Aminuddin Mane , Kahirun Kahirun , Hidayat Herlan , Irsan Mohammad 
Published: December 2022

This study aims to determine the potential for CO2 uptake and carbon storage on the mangrove forest of Parida Village Lasalepa District Muna Regency. This research was conducted in January 2022 at Parida Village, Lasalepa District, Muna Regency. The sampling in this study used the purposive sampling method, the determination of the sampling was selected systematically with an intensity of 1%. The placement of the measuring plots is based on the zoning of the mangrove forest which is made of 3 (three) plots, where each plot is 15 m x 15 m (225 m2). The variables in this study were the diameter of an adult's chest height to determine above-ground biomass and carbon (above ground) without cutting down trees (non-destructive). Biomass is determined by Allometric equations. The carbon is determined by of the biomass. The results showed that the potential for CO2 absorption and carbon storage in mangroves in Parida Village, Lasalepa District, Muna Regency had an average CO2 absorption of 1057,49 ton.ha-1, and carbon storage 288,41 ton.ha-1. The carbon value is influenced by environmental conditions, the type of wood mass, the diameter of the mangrove trunk and the number of species contained in a plot.Keywords: Mangrove Forest, CO2Absorption,Carbon Storage. AbstrakPenelitian ini bertujuan untuk mengetahui potensi serapan CO2 dan simpanan karbon pada hutan mangrove di Desa Parida Kecamatan Lasalepa Kabupaten Muna.Penelitian ini dilaksanakan pada Bulan Januari 2022 bertempat di Desa Parida Kecamatan Lasalepa Kabupaten Muna.Adapun pengambilan sampel dalam penelitian ini menggunakan metode purposive sampling, penentuan pengambilan sampel dipilihsecara sistematis dengan intensitas 1%. Penempatan plot ukur didasarkan pada zonasi hutan mangrove yang dibuat 3 (tiga) plot, dimana masing-masing plot berukuran 15 m x 15 m (225 m2). Variabel dalam penelitian ini yaitu diameter batang untuk menentukan bioamassa dan jumlah karbon diatas permukaan tanah (above ground) dengan tanpa menebang pohon (non destuktif).Biomassa ditentukan dengan persamaan Allometrik.Adapun karbon ditentukan dengan ½ dari biomassa. Hasil penelitian menunjukan bahwa potensi serapan CO2 dan simpanan karbon pada hutan mangrove di Desa Parida Kecamatan Lasalepa Kabupaten Muna memiliki rata-rata serapan CO2 sebesar 1057,49ton.ha-1, serta simpanankarbon 288,41 ton.ha-1. Besar nilai karbon dipengaruhi oleh kondisi lingkungan, jenis masa kayu, diameter batang mangrove dan jumlah jenis yang terdapat dalam suatu plot.Kata Kunci : Hutan Mangrove, Serapan CO2, Simpanan Karbon
DEVELOPMENT OF CIPATUJAH BEACH'S POTENTIAL AS A TOURISM DESTINATION IN TASIKMALAYA REGENCY
Authors: Ngarbingan Hubertina , Suryantari Yulita 
Published: December 2022

The purpose of this research is to determine the potency that can be developed in Cipatujah Beach as a tourism destination in Tasikmalaya Regency. The potency of Cipatujah Beach is categorized based on Cooper theory (2000), those are 4 A aspects: attraction, accessibility, amenities and ancillary. Based on the results of data analysis, Cipatujah Beach has been qualified to reach those aspects with the right development plan. The research method that is used in this research is descriptive qualitative method. The techniques of collecting the data are in-depth interview, observation, and triangulation. The technique of analyzing the data is SWOT analysis. The result of this research shows that Cipatujah Beach can be developed as a tourism destination by utilizing those aspects optimally. Besides, cooperation of stakeholders, local people and tourism industry is very required to create a good and systematic development, to keep the tourism sustainability. Tourism sustainability is an appropriate approach of Cipatujah Beach development as a considered tourism destination for the next generation without defaces the originality of tourism destination.

Keywords: Attraction, Accessibility, Amenity, Ancillary, Sustainability Tourism.
Early detection of gastric cancer via high-resolution terahertz imaging system
Authors: Shi Han , Li Tenghui , Liu Zhaoyang , Zhao Junhua , Qi Feng 
Published: December 2022

Terahertz (THz) wave has demonstrated a good prospect in recent years, but the resolution is still one of the problems that restrict the application of THz technology in medical imaging. Paraffin-embedded samples are mostly used in THz medical imaging studies, which are thicker and significantly different from the current gold standard slice pathological examination in sample preparation. In addition, THz absorption in different layers of normal and cancerous tissues also remains to be further explored. In this study, we constructed a high-resolution THz imaging system to scan non-tumorous adjacent tissue slices and gastric cancer (GC) tissue slices. In this system, a THz quantum cascade laser emitted a pulsed 3 THz signal and the transmitted THz wave was received by a THz detector implemented in a 65 nm CMOS process. The slice thickness was only 20 μm, which was close to that of the medical pathology examination. We successfully found THz transmittance differences between different layers of normal gastric tissues based on THz images, and the resolution could reach 60 μm for the first time. The results indicated that submucosa had a lower THz transmittance than that of mucosa and muscular layer in non-tumorous adjacent tissue. However, in GC tissue, THz transmittance of mucosa and submucosa was similar, caused by the decreased transmittance of mucosa, where the cancer occurs. Therefore, we suppose that the similar terahertz transmittance between gastric mucosa and submucosa may indicate the appearance of cancerization. The images obtained from our THz imaging system were clearer than those observed with naked eyes, and can be directly compared with microscopic images. This is the first application of THz imaging technology to identify non-tumorous adjacent tissue and GC tissue based on the difference in THz wave absorption between different layers in the tissue. Our present work not only demonstrated the potential of THz imaging to promote early diagnosis of GC, but also suggested a new direction for the identification of normal and cancerous tissues by analyzing differences in THz transmittance between different layers of tissue.
Detection of ROS1 gene fusions using next-generation sequencing for patients with malignancy in China
Authors: Li Ning , Chen Zhiqin , Huang Mei , Zhang Ding , Hu Mengna , Jiao Feng , Quan Ming 
Published: December 2022

Objective: This study aimed to identify ROS1 fusion partners in Chinese patients with solid tumors.Methods: Next-generation sequencing (NGS) analysis was used to detect ROS1 rearrangement in 45,438 Chinese patients with solid tumors between 2015 and 2020, and the clinical characteristics and genetic features of gene fusion were evaluated. H&amp;E staining of the excised tumor tissues was conducted. Samples with a tumor cell content ≥ 20% were included for subsequent DNA extraction and sequencing analysis.Results: A total of 92 patients with ROS1 rearrangements were identified using next-generation sequencing, and the most common histological type lung cancer. From the 92 ROS1 fusion cases, 24 ROS1 fusion partners had been identified, including 14 novel partners and 10 reported partners. Of these, CD74, EZR, SDC4, and TPM3 were the four most frequently occurring partners. Fourteen novel ROS1 fusion partners were detected in 16 patients, including DCBLD1-ROS1, FRK-ROS1, and VGLL2-ROS1. In many patients, the ROS1 breakpoint was located between exons 32 and 34.Conclusion: This study describes 14 novel ROS1 fusion partners based on the largest ROS1 fusion cohort, and the ROS1 breakpoint was mostly located between exons 32 and 34. Additionally, next-generation sequencing is an optional method for identifying novel ROS1 fusions.
The thromboxane receptor antagonist NTP42 promotes beneficial adaptation and preserves cardiac function in experimental models of right heart overload
Authors: Mulvaney Eamon P. , Renzo Fabiana , Adão Rui , Dupre Emilie , Bialesova Lucia , Salvatore Viviana , Reid Helen M. , Conceição Glória , Grynblat Julien , Llucià-Valldeperas Aida , Michel Jean-Baptiste , Brás-Silva Carmen , Laurent Charles E. , Howard Luke S. , Montani David , Humbert Marc , Vonk Noordegraaf Anton , Perros Frédéric , Mendes-Ferreira Pedro , Kinsella B. Therese 
Published: December 2022

BackgroundPulmonary arterial hypertension (PAH) is a progressive disease characterized by increased pulmonary artery pressure leading to right ventricular (RV) failure. While current PAH therapies improve patient outlook, they show limited benefit in attenuating RV dysfunction. Recent investigations demonstrated that the thromboxane (TX) A2 receptor (TP) antagonist NTP42 attenuates experimental PAH across key hemodynamic parameters in the lungs and heart. This study aimed to validate the efficacy of NTP42:KVA4, a novel oral formulation of NTP42 in clinical development, in preclinical models of PAH while also, critically, investigating its direct effects on RV dysfunction.MethodsThe effects of NTP42:KVA4 were evaluated in the monocrotaline (MCT) and pulmonary artery banding (PAB) models of PAH and RV dysfunction, respectively, and when compared with leading standard-of-care (SOC) PAH drugs. In addition, the expression of the TP, the target for NTP42, was investigated in cardiac tissue from several other related disease models, and from subjects with PAH and dilated cardiomyopathy (DCM).ResultsIn the MCT-PAH model, NTP42:KVA4 alleviated disease-induced changes in cardiopulmonary hemodynamics, pulmonary vascular remodeling, inflammation, and fibrosis, to a similar or greater extent than the PAH SOCs tested. In the PAB model, NTP42:KVA4 improved RV geometries and contractility, normalized RV stiffness, and significantly increased RV ejection fraction. In both models, NTP42:KVA4 promoted beneficial RV adaptation, decreasing cellular hypertrophy, and increasing vascularization. Notably, elevated expression of the TP target was observed both in RV tissue from these and related disease models, and in clinical RV specimens of PAH and DCM.ConclusionThis study shows that, through antagonism of TP signaling, NTP42:KVA4 attenuates experimental PAH pathophysiology, not only alleviating pulmonary pathologies but also reducing RV remodeling, promoting beneficial hypertrophy, and improving cardiac function. The findings suggest a direct cardioprotective effect for NTP42:KVA4, and its potential to be a disease-modifying therapy in PAH and other cardiac conditions.
Estimating core-mantle boundary temperature from seismic shear velocity and attenuation
Authors: Deschamps Frédéric , Cobden Laura 
Published: December 2022

The temperature at Earth’s core-mantle boundary (CMB) is a key parameter to understand the dynamics of our planet’s interior. However, it remains poorly known, with current estimate ranging from about 3000 K to 4500 K and more. Here, we introduce a new approach based on joint measurements of seismic shear-wave velocity,VS, and quality factor,QS, in the lowermost mantle. Lateral changes in bothVSandQSabove the CMB provide constraints on lateral temperature anomalies with respect to a reference temperature,Tref, defined as the average temperature in the layer immediately above the CMB. The request that, at a given location, temperature anomalies inferred independently fromVSandQSshould be equal gives a constraint onTref. CorrectingTreffor radial adiabatic and super-adiabatic increases in temperature gives an estimate of the CMB temperature,TCMB. This approach further relies on the fact thatVS-anomalies are affected by the distribution of post-perovskite (pPv) phase. As a result, the inferredTrefis linked to the temperatureTpPvat which the transition from bridgmanite to pPv occurs close to the CMB. A preliminary application toVSandQSmeasured beneath Central America and the Northern Pacific suggest that forTpPv= 3500 K,TCMBlies in the range 3,470–3880 K with a 95% likelihood. Additional measurements in various regions, together with a better knowledge ofTpPv, are however needed to determine a precise value ofTCMBwith our method.
Sediment load forecasting of Gobindsagar reservoir using machine learning techniques
Authors: Shaukat Nadeem , Hashmi Abrar , Abid Muhammad , Aslam Muhammad Naeem , Hassan Shahzal , Sarwar Muhammad Kaleem , Masood Amjad , Shahid Muhammad Laiq Ur Rahman , Zainab Atiba , Tariq Muhammad Atiq Ur Rehman 
Published: December 2022

With ever advancing computer technology in machine learning, sediment load prediction inside the reservoirs has been computed using various artificially intelligent techniques. The sediment load in the catchment region of Gobindsagar reservoir of India is forecasted in this study utilizing the data collected for years 1971–2003 using several models of intelligent algorithms. Firstly, multi-layered perceptron artificial neural network (MLP-ANN), basic recurrent neural network (RNN), and other RNN based models including long-short term memory (LSTM), and gated recurrent unit (GRU) are implemented to validate and predict the sediment load inside the reservoir. The proposed machine learning models are validated for Gobindsagar reservoir using three influencing factors on yearly basis [rainfall (Ra), water inflow (Iw), and the storage capacity (Cr)]. The results demonstrate that the suggested MLP-ANN, RNN, LSTM, and GRU models produce better results with maximum errors reduced from 24.6% to 8.05%, 7.52%, 1.77%, and 0.05% respectively. For future prediction of the sediment load for next 22 years, the influencing factors were first predicted for next 22 years using ETS forecasting model with the help of data collected for 33 years. Additionally, it was noted that each prediction’s error was lower than that of the reference model. Furthermore, it was concluded that the GRU model predicts better results than the reference model and its alternatives. Secondly, by comparing the prediction precision of all the machine learning models established in this study, it can be evidently shown that the LSTM and GRU models were superior to the MLP-ANN and RNN models. It is also observed that among all, the GRU took the best precision due to the highest R of 0.9654 and VAF of 91.7689%, and the lowest MAE of 0.7777, RMSE of 1.1522 and MAPE of 0.3786%. The superiority of GRU can also be ensured from Taylor’s diagram. Lastly, Garson’s algorithm and Olden’s algorithm for MLP-ANN, as well as the perturbation method for RNN, LSTM, and GRU models, are used to test the sensitivity analysis of each influencing factor in sediment load forecasting. The sediment load was discovered to be most sensitive to the annual rainfall.
Stigmatization and resilience in inflammatory bowel disease patients at one-year follow-up
Authors: Lenti Marco Vincenzo , Broglio Giacomo , Mengoli Caterina , Cococcia Sara , Borrelli de Andreis Federica , Vernero Marta , Pitotti Lavinia , Padovini Lucia , Secco Matteo , Delliponti Mariangela , Corazza Gino Roberto , Klersy Catherine , Di Sabatino Antonio 
Published: December 2022

IntroductionInflammatory bowel disease (IBD), namely ulcerative colitis and Crohn’s disease, is a chronic relapsing immune-mediated condition that may cause an impairment of social functions due to stigmatisation. Resilience instead is associated with an improvement in coping with adversities and thus may counteract the detrimental effects of stigmatisation. We herein sought to determine the fluctuation of stigmatisation and resilience in a cohort of patients with IBD at 1-year follow-up.MethodsThis is a prospective, monocentric study conducted in a tertiary referral centre. All patients with IBD were assessed at enrolment and at oneyear follow-up. Several clinical and demographic variables were collected. Stigmatisation was assessed through a validated Italian version of the Perceived Stigma Scale for IBD (PSS-IBD), while resilience was assessed through the 25-item Connor Davidson Resilience Scale (CD-RISC25). Also, self-efficacy (SEF) and self-esteem (SES) scales were assessed.ResultsIn this study, 105 patients were included (46 Crohn’s disease, 59 ulcerative colitis; overall mean age 47 years ±11, M:F ratio 1:1.2). None of the 4 scales showed a statistically significant variation at one year compared to baseline (median CD-RISC25 64 at baseline vs 61 at follow-up; SEF 31 vs 30; SES 32.5 vs 32; PSS-IBD 0.45 vs 0.45). A statistically significant and inverse correlation was found between CD-RISC25 and PSS-IBD (rho -0.222, p=0.01), SEF and PSS-IBD (rho -0.219, p= 0.01), SES and PSS-IBD (-0.316, p=0.003). CD-RISC25 was found to be positively associated with inactive IBD (p=0.05).DiscussionIn this prospective study we have shown for the first time that stigmatisation, resilience, SEF and SEM did not change over a one-year time span, suggesting that, based on the information gathered, these characteristics may be independent from IBD severity or IBD flares. Furthermore, we found an inverse correlation of stigma with resilience, SEF and SES, suggesting an important role that these variables may have on preventing stigmatisation.
Short-term effects of estradiol and bisphenol A on gene expression associated with early head mineralization in the seabass Dicentrarchus labrax
Authors: Farcy Emilie , Potier Eric , Leurs Nicolas , Gasset Eric , Dutto Gilbert , Lallement Stéphane , Bourdy Clarence , Debiais-Thibaud Mélanie , Martinand-Mari Camille 
Published: December 2022

IntroductionNatural and synthetic estrogens are pollutants found in aquatic ecosystems at low concentrations reaching ng.L-1 to μg.L-1. At these concentrations, they are able to interfere with the fish endocrine system. When waterborne exposure occurs at early life stages, when blood estrogens concentrations are low, this may have significant consequences for estrogen-sensitive functions such as skeletal development.MethodsTo better understand how (xeno)estrogens may affect early head mineralization, 12 days post-hatch larvae of the European seabass Dicentrarchus labrax were experimentally exposed for 4 days to the natural estrogen estradiol E2 and to the xenoestrogen bisphenol A (BPA), both used at either regulatory concentration of water quality or a 100 times higher concentration. Head mineralization level was assessed using Alizarin red staining, together with the relative quantification of mRNA expression levels of several genes playing key roles in skeletogenesis and estrogen signaling pathways.ResultsWe showed that (xeno)estrogen exposure at early larval stage increases the expression of skeleton-associated genes: matrix proteins encoding genes (col1a2, col2a1a, col2a1b, bgp1a, bgp1b, sparc), proteolytic enzyme encoding genes (ctsk) and transcription and signaling factors (sox9a, sox9b, ihha, runx2, rankl). Although transcriptional overexpression of these genes was significant in larvae exposed to 40 ng.L-1 E2 and to 1.6 and 160 μg.L-1 BPA, increased mineralization was detected only in E2-exposed larvae, suggesting a difference in head skeleton development and remodeling in BPA-treated larvae.DiscussionOur results suggest that these phenotypic differences could be due to the implication of other estrogenic signaling pathways involving both nuclear and membrane-bound estrogen receptors (ERs and GPERs), but also estrogen-related receptors (ERRs). This study brings new insights into the regulatory mechanisms of skeletogenesis by E2 and BPA and into the effects of waterborne exposure to (xeno)estrogens on the early skeletal development of teleost fishes.