bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corrado Ricci e Alberto Bacchi della Lega curatori di Sabadino degli Arienti o della necessità di una nuova edizione della Gynevera de le clare donne
Authors: Rodríguez Mesa Francisco José 
Published: April 2022

Giovanni Sabadino degli Arienti scrive, intorno al 1490, la Gynevera de le clare donne, una silloge composta da trentatré biografie di donne esemplari dedicata a Ginevra Sforza Bentivoglio, moglie e consigliera di Giovanni II, signore de facto di Bologna.
Il testo dell’opera, giuntoci attraverso due soli manoscritti autografi, non venne pubblicato sino al 1888, quando Corrado Ricci e Alberto Bacchi della Lega ne curarono un’edizione per la collana Scelta di curiosità letterarie inedite o rare, diretta da Francesco Zambrini e stampata dalla tipografia bolognese Romagnoli-Dall’Acqua. Questo lavoro, che rivide la luce in un’edizione anastatica solo nel 1969 promossa dalla Commissione per i testi di lingua, presenta non poche lacune, sia per quanto riguarda l’affidabilità del testo sia rispetto ad alcune affermazioni del Ricci e del Bacchi della Lega nell’introduzione dell’opera.
In quest’articolo ci proponiamo di analizzare i punti deboli dell’edizione della Gynevera curata da questi due studiosi, con il proposito di individuare i principali elementi da correggere in vista di una futura pubblicazione dell’opera.
El concepto de belleza femenina en la obra de Agnolo Firenzuola
Authors: García-Pérez María-Isabel , Velázquez García Sara 
Published: April 2022

El escritor florentino Agnolo Firenzuola publicó en el siglo XVI Dialogo delle bellezze delle donne. Esta obra se presenta como un excelente modelo que nos permite analizar la popularización de los debates intelectuales de la época alojados en el diálogo literario, un género clásico muy en boga entre los neoplatónicos como vehículo de intercambio sociocultural que se reavivó durante el período renacentista.
El artículo pretende analizar, por un lado, las características que, según el autor, han de tener las mujeres para ser consideradas bellas (en el más amplio sentido del término) y, por otro, los argumentos que esgrime a favor de la igualdad de género dando lugar a un discurso muy innovador para su época.
PERCEPÇÕES DOS ESTUDANTES DE MEDICINA ACERCA DO ENSINO REMOTO DURANTE A PANDEMIA DO NOVO CORONAVIRUS
Authors: Rodrigues Silva Milena , Santos de Andrade Gabriela , De Miranda Avena Kátia , Quintanilha de Mesquita Luiz Fernando , Dias Faria Álvaro Camilo 
Published: April 2022

O cenário pandêmico modificou a rotina da população mundial em diversos aspectos. No contexto da educação médica, devido às restrições impostas pelo novo Coronavírus, a migração para o modelo remoto de ensino ocasionou mudanças metodológicas sem precedentes. Esse estudo se propõe avaliar a percepção dos estudantes de Medicina acerca do ensino remoto durante a pandemia da COVID-19. Trata-se de estudo transversal, quantitativo, analítico, realizado através da aplicação de questionário virtual sobre as percepções da qualidade de aprendizagem durante a vigência do ensino remoto. Foram investigadas as percepções de 230 acadêmicos de Medicina regularmente matriculados em Instituição de Ensino Superior (IES) que aderiram ao ensino remoto. Verificou-se insatisfação dos estudantes quanto a aprendizagem durante o ensino remoto por não conseguirem manter o ritmo de estudo (74,8%) e a motivação (84,3%). A interrupção das aulas práticas foi fator destacado pela grande maioria dos respondentes (93,5%). Apesar de destacarem a possibilidade de assistirem a aula gravada como ponto positivo, apenas 43,9% acreditam que este novo cenário permitiu organizar melhor horários e afazeres. O ambiente familiar (57,1%) e a conexão com a internet (69,1%) foram considerados como fatores limitantes para um bom desempenho acadêmico. Na percepção dos estudantes, houve prejuízo na qualidade da aprendizagem durante o decurso do ensino remoto, especialmente quanto à dificuldade de manutenção do ritmo e motivação nos estudos. Além disso, sugere-se que limitações e instabilidades de conexão com a internet também interferiram negativamente com o processo de aprendizagem.
Biological control potential of entomopathogenic fungal strains against peach Fruit fly,Bactrocera zonata(Saunders) (Diptera: Tephritidae)
Authors: Murtaza Ghulam , Naeem Muhammad , Manzoor Saba , Khan Hammad Ahmad , Eed Emad M. , Majeed Waqar , Ahmed Makki Hussain , Ramzan Uzma , Ummara Umm E. 
Published: April 2022

The peachfruit fly,Bactrocera zonata(Saunders) is a polyphagous pest in nature, belonging to order,Dipteraand their respective family isTephritidae. It mostly feeds on different crops, vegetables and fruits. Different traditional chemical insecticides have been used to control this notorious pest. Excessive consumption of pesticides has become a major threat to the fresh fruits trade since many importing countries refused to accept the shipments due to public health and environmental concerns. There is a growing trend to control these pests using the most effective biological control methods and other preventive measures have been adopted for reducing their attacks. Fungal agents have been used as biological agents to manage the attack of different insects pest through biological means. The present study was conducted to assess the virulence of three entomopathogenic fungi,Metarhizium anisopliae,Beauveria bassianaandVerticillium lecanii,againstBactrocera zonatastages under different laboratory conditions. The results showed thatB. bassianaandM. anisopliaewere more effective in pathogenicity and potentially kill at all stages ofB. zonataas compared toV. lecanii. The highest mortality rate for the third larval instar and the pupal stage were recorded after exposure to the 1 × 1010conidia/ml concentrations,B. bassiana,with 68.67% and 89.67%, respectively. AdultB. zonataflies were the most susceptible to all entomopathogenic fungi. However,M. anisopliaewas more virulent againstB. zonataadult flies thanB. bassianaandV. lecaniiat 1 × 1010conidial concentration. Therefore, the entomopathogenic fungiB. bassianaandM. anisopliaecan be used as an cost effective bio-insecticide in the integrated pest management programs to controlB. zonata. This study will be helpful to overcome this pest through biological control means.
lncRNA MALAT1 mediates osteogenic differentiation of bone mesenchymal stem cells by sponging miR-129-5p
Authors: Yin Junhao , Zheng Zhanglong , Zeng Xiaoli , Zhao Yijie , Ai Zexin , Yu Miao , Wu Yang’ou , Jiang Jirui , Li Jia , Li Shengjiao 
Published: April 2022

BackgroundBone mesenchymal stem cells (BMSCs) have good osteogenic differentiation potential and have become ideal seed cells in bone tissue engineering. However, the osteogenic differentiation ability of BMSCs gradually weakens with age, and the regulatory mechanism is unclear.MethodWe conducted a bioinformatics analysis, dual-luciferase reporter (DLR) experiment, and RNA binding protein immunoprecipitation (RIP) to explore the hub genes that may affect BMSC functions.ResultsThe expression level of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (Malat1) was significantly higher in the BMSCs from elderly than younger mice, whilemiR-129-5pshowed the opposite trend. The results of alkaline phosphatase staining, quantitative reverse transcription PCR and western blot experiments indicated that inhibiting the expression ofMalat1inhibits the osteogenic differentiation of BMSCs. This effect can be reversed by reducing the expression ofmiR-129-5p. Additionally, DLR and RIP experiments confirmed thatMalat1acts as a sponge formiR-129-5p.ConclusionOverall, our study findings indicated that lncRNAMalat1may play a critical role in maintaining the osteoblast differentiation potential of BMSCs by spongingmiR-129-5p.
Knowledge and Use of Oral Rehydration Solution in the Management of Childhood Diarrhoea among Mothers in a Tertiary Health Facility in Port-Harcourt, Nigeria
Authors: Okechukwu C. , Alabi A. , Yaguo-Ide LE. 
Published: April 2022

Introduction: Oral rehydration solution (ORS) has been a life-saving remedy in the home and hospital management of dehydration, particularly in infants and children under the age of five. The improper use has however resulted in morbidity and mortality in children. The purpose of this study is to assess proper use of ORS by mothers in the management of diarrhoea in under-five children.
Methods: A cross-sectional study was conducted over 3 months. Mothers of children under five years of age presenting with diarrhoea at the Diarrhoea Training Unit of a tertiary hospital were interviewed using a pretested structured interviewer-administered questionnaires. Data was analysed using SPSS version 20.0.
Results: A total of 90 mothers were interviewed. 86.7% of respondents were of a high socioeconomic class. 51.1% of children with diarrhoea were between 6-15months of age. (Mean age of 17 + 12.3 months). Although 93.3% of mothers were aware of ORS, 64.4% reported using it to treat their children. Only 40 (44.4%) respondents constituted ORS appropriately and discarded unused portions at 24 hours.
Conclusion: Although mothers of under-five children are aware of the efficacy of ORS in the management of diarrhoea, their knowledge of its proper use is limited. Increased awareness among mothers of under-five children about the proper use of ORS is necessary to avoid debilitating complications such as dehydration, electrolyte imbalance, etc.
Weyl Semimetal States Generated Extraordinary Quasi‐Linear Magnetoresistance and Nernst Thermoelectric Power Factor in Polycrystalline NbP
Authors: Liu Wei , Wang Zhaohui , Wang Jinhua , Bai Hui , Li Zhi , Sun Jinchang , Zhou Xingyuan , Luo Jiangfan , Wang Wei , Zhang Cheng , Wu Jinsong , Sun Yan , Zhu Zengwei , Zhang Qingjie , Tang Xinfeng 
Published: April 2022

AbstractUnsaturated and extremely large magnetoresistance (MR), as well as the giant Nernst effect, are intriguing transport phenomena in Weyl semimetals, which are technically appealing for potential applications in magneto‐electric sensors and transverse thermoelectric conversion. The prominent properties are originated from Weyl semimetal states, i.e., the coexistence of electron and hole pockets combined with linear band dispersion. However, previous studies have been focused on small‐sized single crystals, rendering the practical applications of Weyl semimetals. Here, it is reported an unsaturated, quasi‐linear MR as well as a very large Nernst power factor PFxy in the prepared centimeter‐sized and polycrystalline Weyl semimetal NbP. An extraordinary MR of ≈2 × 104% is observed below 60 K with a magnetic field up to 55 T and persists to elevated temperatures. The unusual quasi‐linear MR behavior is explained by the theory of classical linear MR arising from structural disorder. The polycrystalline NbP exhibits state‐of‐the‐art PFxy that reaches a maximum value of 74.81 μW cm–1 K–2 at 9 T and 220 K, which is 1.5 times larger than its longitudinal thermoelectric power factor PFxx. Given that polycrystalline Weyl semimetal, NbP is suitable for large‐scale production, the results pave the way for its practical applications in magneto‐electric sensors and transverse thermoelectric conversion.
Programming Cellular Alignment in Engineered Cardiac Tissue via Bioprinting Anisotropic Organ Building Blocks
Authors: Ahrens John H. , Uzel Sebastien G. M. , Skylar‐Scott Mark , Mata Mariana M. , Lu Aric , Kroll Katharina T. , Lewis Jennifer A. 
Published: April 2022

AbstractThe ability to replicate the 3D myocardial architecture found in human hearts is a grand challenge. Here, the fabrication of aligned cardiac tissues via bioprinting anisotropic organ building blocks (aOBBs) composed of human induced pluripotent stem cell derived cardiomyocytes (hiPSC‐CMs) is reported. A bioink composed of contractile cardiac aOBBs is first generated and aligned cardiac tissue sheets with linear, spiral, and chevron features are printed. Next, aligned cardiac macrofilaments are printed, whose contractile force and conduction velocity increase over time and exceed the performance of spheroid‐based cardiac tissues. Finally, the ability to spatially control the magnitude and direction of contractile force by printing cardiac sheets with different aOBB alignment is highlighted. This research opens new avenues to generating functional cardiac tissue with high cell density and complex cellular alignment.
Ultrafast Crystallization of Ordered Mesoporous Metal Oxides and Carbon from Block Copolymer Self‐Assembly and Joule Heating
Authors: Wang Leyan , Seah Geok Leng , Li Yun , Tu Wei Han , Manalastas William , Reavley Matthew J.‐H. , Corcoran Edward W. , Usadi Adam K. , Du Zehui , Madhavi Srinivasan , McConnachie Jonathan M. , Ong Hock Guan , Tan Kwan W. 
Published: April 2022

AbstractConventional heat treatments to generate well‐ordered and crystalline mesoporous oxide and carbon structures are limited by long durations and annealing temperatures that can cause mesostructural collapse. This paper describes a facile strategy coupling block copolymer‐directed self‐assembly with high‐power Joule heating to form highly crystalline and well‐ordered mesoporous oxide and carbon nanostructures within second timeframes. The combined approach is compatible with various functional self‐assembled hybrid systems with a range of crystallization temperatures, generating mesoporous composites of γ‐Al2O3‐carbon, γ‐Al2O3/MgO‐carbon, and anatase‐TiO2‐carbon with p6mm symmetry, non‐close‐packed mesoporous carbon, as well as hierarchical mesoporous α‐Fe2O3‐carbon structures. Removing the polymer/carbon gives well‐defined, highly crystalline mesoporous all‐γ‐Al2O3 and all‐anatase‐TiO2 structures. Impregnation of chloroplatinic acid followed by Joule heating yields platinum nanoparticles decorated on the channel walls of mesoporous γ‐Al2O3‐carbon structures. The resultant Joule‐heating‐induced well‐ordered crystalline mesoporous oxide and oxide‐carbon structures have high thermal and structural stabilities and exhibit better performances in CO2 adsorption capacity and lithium‐ion batteries than conventional heat‐treated counterparts. This approach represents an energy‐efficient and time‐saving route toward ordered porous materials with high surface area and pore accessibility for a wide range of environmental applications such as carbon sequestration, renewable energy storage, and environmental filtration.
A genome‐wide association study of obstructive heart defects among participants in the National Birth Defects Prevention Study
Authors: Rashkin Sara R. , Cleves Mario , Shaw Gary M. , Nembhard Wendy N. , Nestoridi Eirini , Jenkins Mary M. , Romitti Paul A. , Lou Xiang‐Yang , Browne Marilyn L. , Mitchell Laura E. , Olshan Andrew F. , Lomangino Kevin , Bhattacharyya Sudeepa , Witte John S. , Hobbs Charlotte A. ,   the National Birth Defects Prevention Study
Published: April 2022

AbstractObstructive heart defects (OHDs) share common structural lesions in arteries and cardiac valves, accounting for ~25% of all congenital heart defects. OHDs are highly heritable, resulting from interplay among maternal exposures, genetic susceptibilities, and epigenetic phenomena. A genome‐wide association study was conducted in National Birth Defects Prevention Study participants (Ndiscovery = 3978; Nreplication = 2507), investigating the genetic architecture of OHDs using transmission/disequilibrium tests (TDT) in complete case‐parental trios (Ndiscovery_TDT = 440; Nreplication_TDT = 275) and case–control analyses separately in infants (Ndiscovery_CCI = 1635; Nreplication_CCI = 990) and mothers (case status defined by infant; Ndiscovery_CCM = 1703; Nreplication_CCM = 1078). In the TDT analysis, the SLC44A2 single nucleotide polymorphism (SNP) rs2360743 was significantly associated with OHD (pdiscovery = 4.08 × 10−9; preplication = 2.44 × 10−4). A CAPN11 SNP (rs55877192) was suggestively associated with OHD (pdiscovery = 1.61 × 10−7; preplication = 0.0016). Two other SNPs were suggestively associated (p < 1 × 10−6) with OHD in only the discovery sample. In the case–control analyses, no SNPs were genome‐wide significant, and, even with relaxed thresholds ( × discovery < 1 × 10−5 and preplication < 0.05), only one SNP (rs188255766) in the infant analysis was associated with OHDs (pdiscovery = 1.42 × 10−6; preplication = 0.04). Additional SNPs with pdiscovery < 1 × 10−5 were in loci supporting previous findings but did not replicate. Overall, there was modest evidence of an association between rs2360743 and rs55877192 and OHD and some evidence validating previously published findings.
Cardiofacioneurodevelopmental syndrome: Report of a novel patient and expansion of the phenotype
Authors: Abdalla Ebtesam , Alawi Malik , Meinecke Peter , Kutsche Kerstin , Harms Frederike L. 
Published: April 2022

AbstractThe cardiofacioneurodevelopmental syndrome (CFNDS) is characterized by craniofacial anomalies including bilateral cleft lip and palate, cardiac, skeletal, and neurodevelopmental features and additional variable manifestations. Whole‐exome sequencing revealed homozygous loss‐of‐function variants in CCDC32 (alternative name: C15orf57) in both previously described patients. ccdc32 deletion in zebrafish suggests a ciliary contribution to the pathomechanism. We report a 9‐year‐old female patient with CFNDS caused by a homozygous 32,583‐bp deletion affecting CCDC32. Independent of the affected CCDC32 transcript variant this deletion likely leads to loss of the encoded protein. The patient had intellectual disability, marked hypertelorism, bilateral cleft lip and palate, and short stature. She had bilateral conductive hearing loss, small hands and feet, and finger abnormalities. Brain imaging disclosed hypoplastic corpus callosum. We describe a core phenotype comprising developmental delay and bilateral cleft lip and palate in the three individuals with CFNDS. Variable abnormalities of the face, brain, heart, fingers, and toes and postnatal growth retardation or microcephaly can be present. Possible involvement of the uncharacterized CCDC32 protein in the adapter protein 2 (AP2) complex regulating clathrin‐mediated endocytosis has been reported. Cleft palate and cardiac defects observed in mice deficient of different AP2 subunits support a CCDC32 function in the AP2 complex.
RETRACTED: Effects of newly synthesized nanocomposites containing multifunctionalized silicon nitride nanoparticles: A study on structural, thermal, electrochemical, mechanical, morphological, water repellent properties for aerospace components
Authors: Xavier Joseph Raj 
Published: April 2022

AbstractThe silicon nitride (Si3N4) nanoparticles modified by 2,5‐Bis‐(4‐aminophenyl)‐1,3,4‐oxadiazole (BAPOD) investigated by scanning electron microscopy with energy dispersive X‐ray spectroscopy (SEM/EDX), transmission electron microscopy, thermogravimetry (TGA), X‐ray diffraction (XRD), and atomic force microscopy (AFM) were reinforced with polyurethane (PU). The newly synthesized formulations such as PU‐Si3N4, PU‐BAPOD, and PU‐BAPOD/Si3N4 nanocomposite coated AA7055 aluminum alloy were electrochemically studied by scanning electrochemical microscopy (SECM), potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) for their anticorrosion behaviors and compared with pure PU coating. EIS studies revealed excellent protection behavior for the PU‐BAPOD/Si3N4 coated AA7055 aluminum alloy in 3.5% NaCl solution. The coating resistance of PU‐BAPOD/Si3N4 nanocomposite was found to be 5995.23 kΩ.cm2 whereas lower coating resistance was observed for the pure PU coating (141.24 kΩ.cm2). It is found that the coating resistance of PU‐BAPOD/Si3N4 nanocomposite is over 42% higher than that of the PU. The measured current for aluminum ions by SECM investigation over the EP‐BAPOD/Si3N4 nanocomposite coating was very low (1.6 nA) compared with PU‐Si3N4 (7.6 nA) and pure PU coated AA7055 (14.9 nA). The surface morphological studies of the coated AA7055 by SEM/EDX analysis and XRD analysis revealed that the Si3N4 nanoparticles were enriched at the corrosion products which prevented corrosion initiation processes. The enhanced mechanical properties were noticed by mechanical analysis for the PU‐BAPOD/Si3N4 nanocomposite coating when the concentration of nanoparticles was 2 wt%. However, there was a decrease in their mechanical properties beyond 2 wt% due to the aggregation of nanoparticles in the PU coated specimen. The results showed that the newly developed PU‐BAPOD/Si3N4 nanocomposite coating possessed superior corrosion protection and enhanced hydrophobic behaviors (WCA: 149°). Therefore, it was concluded that the newly synthesized PU‐BAPOD/Si3N4 nanocomposite provided excellent barrier, hydrophobic, and mechanical properties due to the addition of BAPOD/Si3N4 nanoparticles to the PU resin which prevented the degradation of materials and helped to prolong the life of the coated AA7055 aluminum alloy.
Theoretical Study on Reaction Mechanisms of Dinitrogen Activation and Coupling by Carbene‐Stabilized Borylenes in Comparison with Intramolecular C−H Bond Activation
Authors: You Feiying , Zeng Jie , Rouf Alvi Muhammad , Dong Shicheng , Zhu Jun 
Published: April 2022

AbstractDinitrogen (N2) activation is particularly challenging due to the significantly strong N≡N bond, let alone the catenation of two N2 molecules. Recent experimental study shows that cyclic (alkyl)(amino)carbene (CAAC)‐stabilized borylenes are able to tackle N2 activation and coupling below room temperature. Here we carry out density functional theory calculations to explore the corresponding reaction mechanisms. The results indicate that the reaction barrier for the dinitrogen activation by the first borylene is slightly higher than that by the second borylene. In addition, replacing the CAAC moiety of the borylenes with cyclic diaminocarbenes (CDACs) could make such dinitrogen activation and coupling more favorable thermodynamically. The reaction mechanisms of the intramolecular C−H bond activation of borylene have also been discussed, which is found to be favorable both thermodynamically and kinetically in comparison with N2 activation. Thus, adequate attention should be paid to the design of borylenes aiming at N2 activation. In addition, our calculations suggest that the CDAC moiety of the borylene could lead to a different product in terms of intramolecular C−H bond activation. All these findings could be useful for the development of dinitrogen activation as well as C−H bond activation by main group species.
Synthesis, Photophysical, Electrochemical, and Non‐linear Optical Properties of Triaryl Pyrazole‐based B‐N Coordinated Boron Compounds
Authors: Mukundam Vanga , Sa Shreenibasa , Kumari Anupa , Teja Ponduru Tharun , Das Ritwick , Venkatasubbaiah Krishnan 
Published: April 2022

AbstractWe report here a set of triaryl pyrazole based B−N coordinated boron compounds (11‐17) synthesized by electrophilic aromatic borylation strategy. All the pyrazole boron compounds were thoroughly characterized using multinuclear NMR spectroscopy, LC–MS, and single crystal X‐ray diffraction analysis (for 12–17). The photoluminescence measurements of 11–17 revealed that the emission peak maxima were tuned based on the substitution on N‐phenyl. The photophysical and electrochemical properties were further supported by theoretical calculations. Z‐scan based investigations at 515 nm pump wavelength showed that B−N coordination led to enhancement of nonlinear absorption (two‐photon absorption (TPA)) in these compounds if an electron deficient moiety is attached. It has also been observed that an appropriate choice of moiety allows to optimally maneuver the molecular polarizability of the π‐system and consequently, assists in controlling the third‐order nonlinear optical response.