bluuebunny/crossref_metadata_2025_split huggingface dataset:
Refugee-background students negotiating academic literacy practices in L2: a dialogical and nexus analytical approach
Authors: Leskinen Kirsi 
Published: October 2022

Abstract
This study explored the academic literacies of multilingual refugee-background students who had completed some higher education studies before migrating to Finland. Previous studies have paid little attention to students like them. The research context is a pilot training programme integrating language and content studies. Applying dialogical and nexus analytical perspectives, the study investigated the sense-making processes of two key participants in a Finnish-medium accountancy course that formed part of the programme. The primary data, comprising interviews and video-recorded meetings between the students and their teachers and tutors, were analysed by applying dialogical interaction analysis and narrative analysis in a nexus analytical framework. The results show that the students actively tried to make sense of the target literacy practices. This was observed in negotiations related to the use of technology, norms on authorship and plagiarism, and autonomy in studying. The course was challenging for the students, possibly because their previous experiences and resources had not prepared them for what was expected of them either explicitly in instructions or more implicitly in institutional discourses. This article concludes that structures and practices can be exclusionary if no attention is paid to them and discusses ways of improving inclusiveness in higher education.
The crystal structure of trans-dichlorido-(ethylenediamine-κ
2
N,N′)-bis(triphenylphosphine-κ
1
P)ruthenium(II), C38H38Cl2N2P2Ru
Authors: Ndlangamandla Nqobile G. , Clayton Hadley S. 
Published: October 2022

Abstract
C38H38Cl2N2P2Ru, monoclinic, P21/c (no. 14), a = 10.8827(3) Å, b = 30.6226(7) Å, c = 20.2089(4) Å, β = 93.8560(10)°, V = 6719.5(3) Å3, Z = 8, Rgt
(F) = 0.0306, wRref
(F
2) = 0.0636, T = 173(2) K.
Impairment in insulin secretion without changes in insulin resistance explains hyperglycemia in patients with acromegaly treated with pasireotide LAR
Authors: Wolf Peter , Dormoy Alexandre , Maione Luigi , Salenave Sylvie , Young Jacques , Kamenický Peter , Chanson Philippe 
Published: October 2022

Objective
Pasireotide is a second-generation somatostatin receptor ligand (SRL) used for treating acromegaly. Its clinical use is limited by adverse effects on glucose homeostasis. The aim of this study was to evaluate longitudinal changes in beta-cell function and insulin sensitivity associated with pasireotide in patients not controlled by first-generation SRLs.

Design
We performed a retrospective study.

Methods
The efficacy (growth hormone (GH)/insulin-like growth factor (IGF-1) concentrations; tumor size) and effect on glucose homeostasis were analyzed in 33 patients. Longitudinal data on oral glucose tolerance tests were available before, shortly (mean ± s.d., 6.1 ± 3.8 months) and long term (24.4 ± 11.1 months) after initiation of pasireotide in 14 patients. Insulin secretion (insulinogenic index; disposition index) and insulin sensitivity were calculated by validated indices.

Results
Pasireotide-induced diabetes occurred in 12 patients (36%). It was mediated by impaired insulin secretion, which occurred shortly after initiation of treatment and then remained stable on long term (insulinogenic index, median (min; max), 80 (12; 542) vs 16 (6.4; 101) vs 25 (3.7; 396) pmol/mmol, respectively; P = 0.028; disposition index, 1.45 (0.42; 4.88) vs 0.53 (0.17; 2.63) vs 0.60 (0.22; 1.71), respectively; P = 0.024). No significant changes in insulin sensitivity were observed, despite a marked reduction of GH/IGF-1 concentrations. Older age and a worse glycemic control at baseline were the strongest predictors for hyperglycemia and the need for antidiabetic treatment.

Conclusion
Worsening of glycemic control during pasireotide therapy is caused by an impaired insulin secretion, whereas insulin sensitivity is not affected. These findings might be important for the choice of antidiabetic treatment for pasireotide-induced hyperglycemia.

Significance statement
Pasireotide, a second-generation SRL used for treating acromegaly, may be associated with glucose metabolism impairment. In a retrospective study of 33 patients, we observed that treatment with pasireotide was associated with normalization of serum IGF-1 in almost 60% of patients, but one-third of patients developed diabetes. In the patients who stopped pasireotide because of hyperglycemia, HbA1c promptly decreased. Longitudinal data in 14 patients show that diabetes is mediated by impaired insulin secretion, which occurred shortly and then remained stable on long term, while no significant changes in insulin sensitivity were observed, despite a marked reduction of GH/IGF-1 concentrations. Older age and a worse glycemic control at baseline were the strongest predictors for hyperglycemia.
INTERDISCIPLINARY COMPETENCIES OF MANAGERS FOR A TECHNOLOGICAL BREAKTHROUGH
Authors: Gitelman L. D. , Isayev A. P. , Kozhevnikov M. V. , Gavrilova T. B. 
Published: October 2022

The article aims to study the structure of and improve the model for the fostering of managerial competencies to solve the problems of a technological breakthrough in the domestic economy. The authors apply their proprietary approach that makes it possible to reveal the range of interdisciplinarity and to specify its content. Methods and tools for mastering the competencies in demand are developed. As the empirical base which proves the validity of their сonclusions, the authors cite their own research as well as the results of the analysis of educational programs in engineering management implemented at the leading universities of the world, and the expert opinions of the heads of energy enterprises and professors of Russian universities. The paper analyzes the key factors in the formation of interdisciplinary competencies: a management paradigm towards which the educational process is oriented, a model of knowledge and skills that is adequate to the content of the tasks of a technological breakthrough, a methodology for analyzing interdisciplinary relationships in managerial decisions. The article outlines the relevant experience of training managers of various levels by the Department of Energy Management Systems and Industrial Enterprises of Ural Federal University.The study is scientifically novel as it discovers a new approach to understanding interdisciplinarity when determining the managerial competencies necessary for a technological breakthrough. The practical significance of the article is due to the fact that it presents the experience of implementing the developed approach to the training of managers with an increased readiness to constantly embrace and implement future technologies.
Assessment of outcome in surgically treated traumatic extradural haematoma patients
Authors: Kapoor Bhavuk , Kapoor Mayank , Vaid Parul 
Published: October 2022

In approximately 2% of all patients with head injuries, Extradural haematoma occurs. Immediate diagnosis and surgical evacuation is usually required. Outcome in patient with EDH can be assessed using Glasgow outcome score (GOS). Five parameters of outcome we have measured in our study are - good recovery, moderate disability, severe disability, vegetative state and death.Assessment of outcome of patient by using Glasgow outcome score (GOS) and assessing the outcome with respect to the initial GCS at admission was done.Most (51.42%) of the patients were in the age group of 16-31 years. RTA was the most common (51.42%) cause for EDH occurrence. Most of the patients (57.14%) had GCS of 13-15 in our study. Majority of the patients (68.57%) had a Glasgow outcome score of 5, indicating a good outcome. 51.42% of patients having a GCS of 13-15 had a good outcome, whereas 11.42% of patients having GCS of 9-12 and 5.71% of patients having GCS of ≤ 8 had good outcome.EDH is one of the most serious complications in head injury. It requires immediate diagnosis and management. Urgent surgical intervention improves the outcome Mild head injury patients (GCS 13-15) have good outcome (GOS 5) as compared to with severe head injury (GCS ≤ 8) patients. Lower GCS patients have poor outcome.
Arquitetura entre plano, truque e finta
Authors: Capillé Cauê , Cruz Mariana 
Published: October 2022

Nesse artigo, argumentamos que uma conciliação racional pelo ‘plano’ é apenas um modo de atuação arquitetônica, isto é, há ao menos outros dois modos que podem ser considerados ao projetar: tanto o ‘truque’ dissimulado que dissocia declaração de operação; quanto a ‘finta’ que abertamente declara sua oposição, mas que ginga marginalmente como forma de desvia-la e vence-la. Além disso, defendemos que embora sejamos treinados majoritariamente para projetar por planos, os contextos e desafios urbanos contemporâneos têm nos exigido saber atuar por truques e fintas – especialmente nas condições políticas do Sul Global. Esse artigo pretende, portanto, auxiliar na construção teórica dessas duas outras maneiras de projetar. Para isso, revisa a proposta teórica de Keller Easterling sobre ‘hackeamento espacial’ e propõe que a obra de Cildo Meireles “Inserções em circuitos ideológicos” pode ser considerada como importante referência político/estética para o truque e a finta arquitetônicos, pois oferece lições para uma construção teórica sobre a diferença entre ambas.
Nomos and Nous. Which Are Plato’s Criteria for the Definition of a Just City?
Authors: Migliori Maurizio 
Published: October 2022

SIn Plato, two different visions of politics coexist: care of the soul and care of the polis. A second point is Plato’s systemic and holistic view. Every reality is a whole made up of parts that depend on the whole. Finally, the whole is a principle of order that has a rational foundation in the Ideas. Consequently, the action of the human being is and must be rational. The link between intelligence and law, underlined by the similarity of the two words, nous and nomos, is posed in various ways. The centrality of intelligent intervention clashes with the lack of credit that Plato gives to human action. The polis is marked by diversity and conflict. Human constitutions must use the laws, a rigid tool that, if imitate the paradigm, can counteract the prevalence of disorder. In Plato’s political philosophy the concept of imitation is fundamental. The ideal paradigm is useful for guilding the true politician in his rational effort to propose laws.
But this centrality of intelligent intervention clashes with the lack of credit that Plato gives to human action. When this action is positive, it is a sort of miracle. In fact, the polis is marked by diversity and, therefore, by the conflict.
In this situation Plato proposes a complex of ideal models: the first, a perfect model of polis in the Republic, and a second model in the Laws, that is similar to the first at the highest possible level, and a third, that Plato did not have time to write. These paradigms can be useful, but it is impossible to govern the state “in a scientific manner”. The human constitutions must use the laws, a rigid tool that, if imitate the paradigm, can counteract the prevalence of disorder. In Plato's political philosophy the concept of imitation is fundamental. The ideal paradigm is useful because it guides the true politician, in his rational effort to propose laws.
In summary, Plato does not have a utopian or abstract vision of politics. It is not possible to close him in an elementary and one-sided formula: its vision of human complexity, both personal and social, and its theoretical richness propose and require a structurally multifocal reading
Pengaruh Independensi, Pengalaman, dan Penerapan Teknik Audit Berbantuan Komputer (TABK) Terhadap Efektivitas Pelaksanaan Audit Investigatif Dalam Mendeteksi Kecurangan
Authors: Fauzi Mokhammad Ridwan , Choirul Anwar  , Ulupui I Gusti Ketut Agung 
Published: October 2022

Abstract
This study was conducted to obtain empirical evidence regarding the Effect of Independence, Experience, and Application of Computer Assisted Audit Techniques (TABK) on the Effectiveness of Investigative Audit Implementation in Detecting Fraud. This study uses primary data with a sample of investigative auditors working at the Central Office of the Indonesian Supreme Audit Board (BPK RI), Central Jakarta. The sampling technique uses a random sampling method with 55 respondents. Hypothesis testing uses multiple linear regression analysis method with a significance level of 5%. Based on the results of the analysis conducted, it can be concluded that partially, independence has a significant positive effect on the effectiveness of investigative audit in detecting fraud, experience has a significant positive effect on the effectiveness of investigative audit in detecting fraud, and the application of TABK has a significant positive effect on the effectiveness of investigative audit in detect fraud. Simultaneously, independence, experience, and application of TABK have a significant positive effect on the effectiveness of investigative audits in detecting fraud.
Abstrak
Penelitian ini dilakukan untuk memperoleh bukti empiris mengenai Pengaruh Independesi, Pengalaman, dan Penerapan Teknik Audit Berbantuan Komputer (TABK) Terhadap Efektivitas Pelaksanaan Audit Investigatif Dalam Mendeteksi Kecurangan. Penelitian ini menggunakan data primer dengan sampel auditor investigatif yang bekerja di Kantor Pusat Badan Pemeriksa Keuangan Republik Indonesia (BPK RI) Jakarta Pusat. Teknik sampling menggunakan metode random sampling dengan 55 responden. Pengujian hipotesis menggunakan metode analisis regresi linear berganda dengan tingkat signifikansi 5%. Berdasarkan hasil analisis yang dilakukan, dapat disimpulkan bahwa secara parsial, independensi berpengaruh positif signifikan terhadap efektivitas pelaksanaan audit investigatif dalam mendeteksi kecurangan, pengalaman berpengaruh positif signifikan terhadap efektivitas pelaksanaan audit investigatif dalam mendeteksi kecurangan, dan penerapan TABK berpengaruh positif signifikan terhadap efektivitas pelaksanaan audit investigatif dalam mendeteksi kecurangan. Secara simultan, independensi, pengalaman, dan penerapan TABK berpengaruh positif signifikan terhadap efektivitas pelaksanaan audit investigatif dalam mendeteksi kecurangan.
Detection of the continuous gravitational wave of HM Cancri
Authors: Weidner Herbert 
Published: October 2022

Abstract
HM Cancri is expected to be be one of the brightest sources of gravitational waves in our galaxy. Despite its known frequency, the radiation could not be detected so far. A new method eliminates the strong phase modulation caused by the earth's orbit and drastically reduces the bandwidth. Therefore, the GW can be easily identified in the records of numerous superconducting gravimeters. The determined parameters of the GW agree very well with the results of previous observations of the double star system in the X-ray range.
Intrathecal magnesium delivery for Mg++-insensitive NMDA receptor activity due to GRIN1 mutation
Authors: Lewis Sara A. , Shetty Sheetal , Gamble Sean , Heim Jennifer , Zhao Ningning , Stitt Gideon , Pankratz Matthew , Mangum Tara , Marku Iris , Rosenberg Robert B. , Wilfong Angus A. , Fahey Michael C. , Kim Sukhan , Myers Scott J. , Appavu Brian , Kruer Michael 
Published: October 2022

Abstract
Background
Mutations in the NMDA receptor are known to disrupt glutamatergic signaling crucial for early neurodevelopment, often leading to severe global developmental delay/intellectual disability, epileptic encephalopathy, and cerebral palsy phenotypes. Both seizures and movement disorders can be highly treatment-refractory.
Results
We describe a targeted ABA n = 1 patient trial with intrathecal MgSO4, rationally designed based on the electrophysiologic properties of this gain of function mutation in the GRIN1 NMDA subunit.
Conclusion
Although the invasive nature of the trial necessitated a short-term, non-randomized, unblinded intervention, multimodal neurophysiologic monitoring indicated benefit, providing class II evidence in support of intrathecal MgSO4 for select forms of GRIN disorders.
Effect of Remdesivir on moderate to severe COVID-19 patients’ outcomes.
Authors: Aboelsaad Iman , Ashmawy Rasha , Mahrous Doaa , Sharaf Sandy , Aly Shahinda , Abdullatif Sara , Fakhry Ayat , Hassan Basma , Khamis Dalia , Aldakhs Alaa , Kamal Ehab 
Published: October 2022

Abstract
Background: Remdesivir is a broad-spectrum antiviral that has been approved as promising medicine worldwide for the fatal pandemic COVID-19 disease. There is a debate over its efficacy, with different studies taking into account a variety of factors. Therefore, we conducted this study to evaluate the primary composite outcome of mortality rate, need for mechanical ventilation, and escalation of care among Remdesivir (RDV) and non-Remdesivir (NoRDV) groups.
Methods: Patients with moderate and severe COVID-19, as confirmed by the CPR, were observed retrospectively, before and after including remdsivir in the treatment protocol in the period from August 2020 to February 2021.
Result: From the 509 hospitalized patients, 35% received Remdesivir, with 64% being severe patients. The median age in both groups was 59 years old, and there was no significant difference between the two groups regarding gender, baseline characteristics, and comorbidities. In contrast, the median hospital length of stay in the RDV group was lower (8 days) than in the RDV group (8 days) than the NoRDV (9 days), P= 0.004.
The composite outcome was 17.7% in the RDV group and 22.2% in the NoRDV group, but the difference was statistically insignificant (p-value 0.289). Adjusted logistic regression demonstrated a non-significant lower association of the composite outcome with RDV use (OR 0.623, 95CI% 0.37-1.02), and a significant reduction occurred in patients <60 years old (OR 0.39, 95%CI 0.17 – 0.83). However, survival analysis for mortality, MV, and transfer to a higher level revealed insignificant differences in the median time between groups. Subgroup analyses showed that RDV utilization had a non-significant effect on the risk of all three outcomes across different groups.
Conclusion: Despite controlling all patient characteristics, treatment with RDV did not improve patient outcomes over other antivirals and standard care. There is an urgent need for further studies to investigate and evaluate new therapeutic approaches or combinations.
Three new species of Trichoderma from soils in China
Authors: Zhao Rui , Mao Li-Juan , Zhang Chu-Long 
Published: October 2022

Abstract
Trichoderma spp. are diverse fungi with wide distribution. In this study, we report three new species of Trichoderma, named as T. nigricans, T. densissimum and T. paradensissimum, which were collected from soils in Shandong, Shanxi and Shannxi provinces of China. Their description is based on morphology and phylogenetic analyses. Subsequent phylogenetic analysis and pairwise similarity calculation were conducted using two DNA barcode loci, the second largest nuclear RNA polymerase subunit encoding gene (rpb2) and the translation elongation factor 1- alpha encoding gene (tef 1), respectively, based on the analysis of the primary barcode locus, internal transcribed spacer (ITS) of the ribosomal DNA. The pairwise similarities of tef1 and rpb2 showed that all of them meet the Trichoderma new species standard. In the phylogenetic analysis, each new species formed a distinct clade: T. nigricans is a new member of the Atroviride Clade, and T. densissimum and T. paradensissimum belong to the Harzianum Clade. Compared with closely related species, T. nigricans is characterized by its growth, chlamydospores and odor; T. densissimum is easily distinguished by its relatively large chlamydospores; T. paradensissimum can be recognized by the green to yellow and inconspicuously zonate white pustules formed on PDA or MEA.
Amburana cearensis seed extract stimulates astrocyte glutamate homeostatic mechanisms in hippocampal brain slices and protects oligodendrocytes against ischemia
Authors: Ferreira Rafael Short , Ribeiro Paulo Roberto , Silva Juliana Helena Castro e , Hoppe Juliana Bender , Almeida Monique Marylin Alves , Ferreira Beatriz Correia Lima , Andrade Gustavo Borges , Souza Suzana Braga , Ferdandez Luzimar Gonzaga , Costa Maria de Fátima Dias , Salbego Christianne Gazzana , Rivera Andrea Domenico , Longoni Aline , De Assis Adriano Martimbianco , Pieropan Francesca , Moreira José Cláudio Fonseca , Costa Silvia Lima , Butt Arthur Morgan , Silva Victor Diogenes Amaral 
Published: October 2022

Abstract
Background.
Stroke is a leading cause of death and disability worldwide. A major factor in brain damage following ischemia is excitotoxicity caused by elevated levels of the neurotransmitter glutamate. In the brain, glutamate homeostasis is a primary function of astrocytes. Amburana cearensis has long been used in folk medicine and seed extract obtained with dichloromethane (EDAC) have previously been shown to exhibit cytoprotective activity in vitro. The aim of the present study was to analyse the activity of EDAC in hippocampal brain slices.
Methods.
We prepared a dichloromethane extract (EDAC) from A. cearensis seeds and characterized the chemical constituents by 1H and 13C-NMR. Hippocampal slices from P6-8 or P90 Wistar rats were used for cell viability assay or glutamate uptake test. Hippocampal slices from P10-12 transgenic mice SOX10-EGFP and GFAP-EGFP and immunofluorescence for GS, GLAST and GLT1 were used to study oligodendrocytes and astrocytes.
Results.
Astrocytes play a critical role in glutamate homeostasis and we provide immunohistochemical evidence that in excitotoxicity EDAC increased expression of glutamate transporters and glutamine synthetase, which is essential for detoxifying glutamate. Next, we directly examined astrocytes using transgenic mice in which glial fibrillary acidic protein (GFAP) drives expression of enhanced green fluorescence protein (EGFP) and show that glutamate excitotoxicity caused a decrease in GFAP-EGFP and that EDAC protected against this loss. This was examined further in the oxygen-glucose deprivation (OGD) model of ischemia, where EDAC caused an increase in astrocytic process branching, resulting in an increase in GFAP-EGFP. Using SOX10-EGFP reporter mice, we show that the acute response of oligodendrocytes to OGD in hippocampal slices is a marked loss of their processes and EDAC protected oligodendrocytes against this damage.
Conclusion.
This study provides evidence that EDAC is cytoprotective against ischemia and glutamate excitotoxicity by modulating astrocyte responses and stimulating their glutamate homeostatic mechanisms.
Breakdown of the scaling relation of anomalous Hall effect in Kondo lattice ferromagnet USbTe
Authors: Siddiquee Hasan , Broyles Christopher , Kotta Erica , Liu Shouzheng , Peng Shiyu , Kong Tai , Kang Byungkyun , Zhu Qiang , Lee Yongbin , Ke Liqin , Weng Hongming , Denlinger Jonathan , Wray L. Andrew , Ran Sheng 
Published: October 2022

Abstract
The interaction between strong correlation and Berry curvature is an open territory of in the field of quantum materials. Here we report large anomalous Hall conductivity in a Kondo lattice ferromagnet USbTe which is dominated by intrinsic Berry curvature at low temperatures. However, the Berry curvature induced anomalous Hall effect does not follow the scaling relation derived from Fermi liquid theory, and has a strong temperature dependence. The onset of the Berry curvature contribution to the anomalous Hall effect coincides with the Kondo coherent temperature. Combined with ARPES measurement and DMFT calculations, this strongly indicates that Berry curvature is hosted by the flat bands induced by Kondo hybridization at the Fermi level. Our results demonstrate that the Kondo coherence of the flat bands has a dramatic influence on the low temperature physical properties associated with the Berry curvature, calling for new theories of scaling relations of anomalous Hall effect to account for the interaction between strong correlation and Berry curvature.