bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevated Plasma Complement C1q Levels Contribute to a Poor Prognosis After Acute Primary Intracerebral Hemorrhage: A Prospective Cohort Study
Authors: Wang Zefan , Wu Xiaoyu , Yan Tian , Liu Ming , Yu Wenhua , Du Quan , Hu Wei , Zheng Yongke , Zhang Zuyong , Wang Keyi , Dong Xiaoqiao 
Published: June 2022

ObjectiveThe complement cascade is activated early following intracerebral hemorrhage (ICH) and causes acute brain injury. We intended to explore the effects of plasma complement component 1q (C1q) levels on hemorrhagic severity and functional outcome in ICH patients.MethodsIn this prospective cohort study, we measured the plasma C1q levels of 101 ICH patients and 101 healthy controls. The Glasgow Coma Scale (GCS) score and hematoma volume were used to assess the ICH severity. Poor prognosis was referred to as a Glasgow Outcome Scale (GOS) score of 1-3 at three months following a stroke. A multivariate logistic regression model was configured to determine the independent relation of plasma C1q levels to severity and poor prognosis. Under receiver operating characteristic (ROC) curve, prognostic capability of plasma C1q levels was evaluated.ResultsThere was a significant elevation of plasma C1q levels in patients, as compared to controls [median (percentiles 25th-75th), 225.04 mg/l (156.10-280.15 mg/l) versus 88.18 mg/l (70.12-117.69 mg/l); P&lt;0.001]. Plasma C1q levels of patients were independently related to GCS score (t =-3.281, P=0.001) and hematoma volume (t = 2.401, P=0.018), and were highly correlated with the GOS score at 3 months post-stroke (r=-0.658, P&lt;0.001). Plasma C1q levels were obviously higher in poor prognosis patients than in other remainders (median percentiles 25th-75th), 278.40 mg/l (213.81-340.05 mg/l) versus 174.69 mg/l (141.21-239.93 mg/l); P&lt;0.001). Under the ROC curve, plasma C1q levels significantly discriminated the development of poor prognosis (area under ROC curve 0.795; 95% confidence interval, 0.703–0.869; P&lt;0.001). Using maximum Youden method, plasma C1q levels &gt; 270.11 mg/l distinguished patients at risk of poor prognosis at 3 months with 56.52% sensitivity and 94.55% specificity. Meanwhile, the prognostic predictive ability of plasma C1q levels was equivalent to those of GCS score and hematoma volume (both P&gt;0.05). Moreover, plasma C1q levels &gt; 270.11 mg/l independently predicted a poor prognosis at 3 months (odds ratio, 4.821; 95% confidence interval, 1.211-19.200; P=0.026).ConclusionPlasma C1q levels are closely related to the illness severity and poor prognosis of ICH at 3 months. Hence, complement C1q may play an important role in acute brain injury after ICH and plasma C1q may represent a promising prognostic predictor of ICH.
Evaluation of Bedtime vs. Morning Levothyroxine Intake to Control Hypothyroidism in Older Patients: A Pragmatic Crossover Randomized Clinical Trial
Authors: de Mello Renato Bandeira , Giassi Karina , Stahl Gabriela , Machado Assis Maria Luisa , Flores Marina Siqueira , de Lima Bruna Cambrussi , Piccoli Vanessa , da Costa Rodrigues Ticiana 
Published: June 2022

IntroductionDrug scheduling in older adults can be a challenge, especially considering polypharmacy, physical dependency, and possible drug interactions. Properly testing alternative treatment regimens could therefore help to overcome treatment barriers. Hypothyroidism is a prevalent condition in older adults, however, studies evaluating L-thyroxine treatment effectiveness in this specific age group are still lacking. Most studies testing an evening administration of levothyroxine were mainly composed of younger adults. Therefore, this trial is aimed to assess if evening levothyroxine (LT4) administration can effectively control hypothyroidism in older patients.Materials and MethodsA randomized crossover clinical trial was conducted between June 2018 and March 2020 at the Hospital de Clínicas de Porto Alegre, a teaching hospital in Brazil, to compare the efficacy of morning and evening administration of LT4 for hypothyroidism control in older patients. The study protocol is published elsewhere. A total of 201 participants, ≥60 years old, with primary hypothyroidism treated with LT4 for at least 6 months and on stable doses for at least 3 months were included. Participants were randomly assigned to a starting group of morning LT4 intake (60 min before breakfast) or bedtime LT4 intake (60 min after the last meal). After ≥12 weeks of follow-up, a crossover between strategies was performed. The primary outcome was the change in serum thyrotropin (Thyroid-Stimulating Hormone; TSH) levels after 12 weeks of each LT4 administration regimen.ResultsA total of 201 participants with mean age of 72.4 ± 7.2 years were included, out of which 84.1% were women; baseline characteristics and frequency of controlled hypothyroidism were similar between groups. Mean baseline TSH was 3.43 ± 0.25 mUI/L. In total, 118 participants attended three meetings, allowing 135 comparisons by crossover analytic strategy. Mean TSH levels after follow-up were 2.95 ± 2.86 in the morning group and 3.64 ± 2.86 in the bedtime group,p= 0.107.DiscussionThyroid-Stimulating Hormone levels and frequency of controlled hypothyroidism were similar during the follow-up period regardless of the treatment regimen (morning or bedtime).
A Standardized Multimodal Neurological Monitoring Protocol-Guided Cerebral Protection Therapy for Venoarterial Extracorporeal Membrane Oxygenation Supported Patients
Authors: Shi Xiaobei , Gu Qiao , Li Yiwei , Diao Mengyuan , Wen Xin , Hu Wei , Xi Shaosong 
Published: June 2022

BackgroundThe main objective of this study was to investigate the role of a multimodal neurological monitoring (MNM)-guided protocol in the precision identification of neural impairment and long-term neurological outcomes in venoarterial extracorporeal membrane oxygenation (VA-ECMO) supported patients.MethodsWe performed a cohort study that examined adult patients who underwent VA-ECMO support in our center between February 2010 and April 2021. These patients were retrospectively assigned to the “with MNM group” and the “without MNM group” based on the presence or absence of MNM-guided precision management. The differences in ECMO-related characteristics, evaluation indicators (precision, sensitivity, and specificity) of the MNM-guided protocol, and the long-term outcomes of the surviving patients were measured and compared between the two groups.ResultsA total of 63 patients with VA-ECMO support were retrospectively assigned to the without MNM group (n = 35) and the with MNM group (n = 28). The incidence of neural impairment in the without MNM group was significantly higher than that in the with MNM group (82.1 vs. 54.3%, P = 0.020). The MNM group exhibited older median ages [52.5 (39.5, 65.3) vs. 31 (26.5, 48.0), P = 0.008], a higher success rate of ECMO weaning (92.8 vs. 71.4%, P = 0.047), and a lower median duration of building ECMO [40.0 (35.0, 52.0) vs. 58.0 (48.0, 76.0), P = 0.025] and median ECMO duration days [5.0 (4.0, 6.2) vs. 7.0 (5.0, 10.5), P = 0.018] than the group without MNM. The MNM-guided protocol exhibited a higher precision rate (82.1 vs. 60.0%), sensitivity (95.7 vs. 78.9%), and specificity (83.3 vs. 37.5%) in identifying neural impairment in VA-ECMO support patients. There were significant differences in the long-term outcomes of survivors at 1, 3 and 6 months after discharge between the two groups (P &lt; 0.05). However, the results showed no significant differences in ICU length of stay (LOS), hospital LOS, survival to discharge, or 28-day mortality between the two groups (P &gt; 0.05).ConclusionThe MNM-guided protocol is conducive to guiding intensivists in the improvement of cerebral protection therapy for ECMO-supported patients to detect and treat potential neurologic impairment promptly, and then improving long-term neurological outcomes after discharge.
Individuals With Higher CD4/CD8 Ratio Exhibit Increased Risk of Acute Respiratory Distress Syndrome and In-Hospital Mortality During Acute SARS-CoV-2 Infection
Authors: Pascual-Dapena Ana , Chillaron Juan José , Llauradó Gemma , Arnau-Barres Isabel , Flores Juana , Lopez-Montesinos Inmaculada , Sorlí Luisa , Luis Martínez-Pérez Juan , Gómez-Zorrilla Silvia , Du Juan , García-Giralt Natalia , Güerri-Fernández Robert 
Published: June 2022

BackgroundCD4/CD8 ratio has been used as a quantitative prognostic risk factor in patients with viral infections. This study aims to assess the association between in-hospital mortality and at admission CD4/CD8 ratio among individuals with acute SARS-CoV-2 infection.MethodsThis is a longitudinal cohort study with data of all consecutive patients admitted to the COVID-19 unit at Hospital del Mar, Barcelona, Spain for ≥48 h between March to May 2020. The CD4+ CD8+ T-cell subset differentiation was assessed by flow cytometry at admission as well as a complete blood test. Patients were classified according to CD4/CD8 ratio tertiles. The primary outcome was in-hospital mortality and the secondary outcome was acute respiratory distress (ARDS).ResultsA total of 338 patients were included in the cohort. A high CD4/CD8 ratio (third tertile) was associated with a higher in-hospital mortality [adjusted Cox model hazard ratio (HR) 4.68 (95%CI 1.56–14.04, p = 0.006), reference: second tertile HR 1]. Similarly, a high CD4/CD8 ratio (third tertile) was associated with a higher incidence of ARDS [adjusted logistic regression model OR 1.97 (95%CI 1.11–3.55, p = 0.022) reference: second tertile HR 1]. There was a trend of higher in-hospital mortality and incidence of ARDS in patients within the first tertile of CD4/CD8 ratio compared with the second one, but the difference was not significant. No associations were found with total lymphocyte count or inflammatory parameters, including D-dimer.ConclusionCD4/CD8 ratio is a prognostic factor for the severity of COVID-19, reflecting the negative impact on prognosis of those individuals whose immune response has abnormal CD8+ T-cell expansion during the early response to the infection.
Modulation of Cellular Circadian Rhythms by Secondary Metabolites of Lichens
Authors: Srimani Soumi , Schmidt Cosima Xenia , Gómez-Serranillos Maria Pilar , Oster Henrik , Divakar Pradeep K. 
Published: June 2022

BackgroundMost mammalian cells harbor molecular circadian clocks that synchronize physiological functions with the 24-h day-night cycle. Disruption of circadian rhythms, through genetic or environmental changes, promotes the development of disorders like obesity, cardiovascular diseases, and cancer. At the cellular level, circadian, mitotic, and redox cycles are functionally coupled. Evernic (EA) and usnic acid (UA), two lichen secondary metabolites, show various pharmacological activities including anti-oxidative, anti-inflammatory, and neuroprotective action. All these effects have likewise been associated with a functional circadian clock.Hypothesis/PurposeTo test, if the lichen compounds EA and UA modulate circadian clock function at the cellular level.MethodsWe used three different cell lines and two circadian luminescence reporter systems for evaluating dose- and time-dependent effects of EA/UA treatment on cellular clock regulation at high temporal resolution. Output parameters studied were circadian luminescence rhythm period, amplitude, phase, and dampening rate.ResultsBoth compounds had marked effects on clock rhythm amplitudes and dampening independent of cell type, with UA generally showing a higher efficiency than EA. Only in fibroblast cells, significant effects on clock period were observed for UA treated cells showing shorter and EA treated cells showing longer period lengths. Transient treatment of mouse embryonic fibroblasts at different phases had only minor clock resetting effects for both compounds.ConclusionSecondary metabolites of lichen alter cellular circadian clocks through amplitude reduction and increased rhythm dampening.
The Mediating Role of Coping Style in the Relationship Between Sleep Quality and Burnout: A Cross-Sectional Study Among Psychiatric Nurses
Authors: Yin Ming , Li Weiqin , Yang Qun , Yue Yan , Fang Xiaojia , Yang Zhong , Wang Xinda , Liu Qin , Kong Fanzhen , Ji Caifang , Lv Xiaoli , Wang Hao , Yuan Nian , Li Zhe , Zhang Caiyi , Li Kan , Yang Yang , Du Xiangdong 
Published: June 2022

BackgroundAlthough sleep quality is clearly associated with job burnout as shown in the existing research, the mechanism underpinning such relationship remains undefined. This work, thus, aimed to assess the current situation of sleep quality and burnout in Chinese psychiatric nurses, and to analyze the relationships between sleep quality, burnout and coping style, in order to provide possible targets to enhance mental health and wellbeing among psychiatric nurses.MethodThis cross-sectional study was carried out in seven rehabilitation centers located in four different regions of China. The Pittsburgh Sleep Quality Index, the Epworth Sleeping Scale, the Maslach Burnout Inventory General Survey, and the Coping Style Questionnaire were distributed to 853 nurses in various mental hospitals, with a total of 664 participants being recruited in the final research.ResultsThe results of this current study showed a high prevalence of sleep disorders and burnout in Chinese psychiatric nurses. Moreover, emotional exhaustion (r = 0.456), cynicism (r = 0.323) and negative coping style (r = 0.191) in nurses were all positively correlated with total Pittsburgh Sleep Quality Index (PSQI) score, while professional efficacy (r = −0.079) and positive coping style (r = −0.140) were negatively correlated with total PSQI score. More interestingly, of all negative coping strategies, we found that self-blame had the most significant effect (β = 0.156).ConclusionsThe above results showed that coping style mediates the association of poor sleep quality with job burnout in Chinese psychiatric nurses. This study claimed that there is an urgent need to development the coping skills to sustain a healthy work life for nurses.
Test Results From the Prelaunch Characterization Campaign of the Engineering Test Unit of the Ocean Color Instrument of NASA’s Plankton, Aerosol, Cloud and Ocean Ecosystem (PACE) Mission
Authors: Meister Gerhard , Knuble Joseph J. , Chemerys Leland H. , Choi Hyeungu , Collins Nicholas R. , Eplee Robert E. , Gliese Ulrik , Gorman Eric T. , Jepsen Kim , Kitchen-McKinley Samuel , Lee Shihyan , Mcintire Jeffrey W. , Patt Frederick S. , Tse Bradley C. , Waluschka Eugene , Werdell P. Jeremy 
Published: June 2022

This paper summarizes the results from the system level test campaign of the Engineering Test Unit (ETU) of the ‘Ocean Color Instrument’ (OCI), the primary payload of NASA’s ‘Plankton, Aerosol, Cloud and ocean Ecosystem’ (PACE) mission. The main goals of the test campaign were to optimize characterization procedures and evaluate system level performance relative to model predictions. Critical performance parameters such as radiometric gain, signal-to-noise ratio, polarization, instantaneous field-of-view, temperature sensitivity, relative spectral response and stability were evaluated for wavelengths from 600 to 2,260 nm and are in line with expectations. We expect the OCI flight unit to meet the PACE mission performance requirements. Building and testing the ETU has been extremely important for the development of the OCI flight unit (e.g. improved SNR by increasing the aperture, optimized thermal design), and we strongly recommend the inclusion of an ETU in the development of future spaceborne sensors that rely on novel technological designs. ETU testing led to the discovery of a hysteresis issue with the SWIR bands, and a correction algorithm was developed. Also, the coregistration of the SWIR bands relative to each other is worse than expected, but this was discovered too late in the schedule to remediate.
Nutritional Risk Factors Associated with Vasomotor Symptoms in Women Aged 40–65 Years
Authors: Tijerina Alexandra , Barrera Yamile , Solis-Pérez Elizabeth , Salas Rogelio , Jasso José L. , López Verónica , Ramírez Erik , Pastor Rosario , Tur Josep A. , Bouzas Cristina 
Published: June 2022

Vasomotor symptoms (VMS) are the most common symptoms among menopausal women; these include hot flashes and night sweats, and palpitations often occur along with hot flashes. Some studies in Mexico reported that around 50% of women presented with VMS mainly in the menopausal transition. It has been proven that VMS are not only triggered by an estrogen deficiency, but also by nutritional risk factors. Evidence of an association between nutritional risk factors and VMS is limited in Mexican women. The aim of this study is to identify nutritional risk factors associated with VMS in women aged 40–65 years. This is a comparative cross-sectional study, undertaken in a retrospective way. A sample group (n = 406 women) was divided into four stages according to STRAW+10 (Stages of Reproductive Aging Workshop): late reproductive, menopausal transition, early postmenopause, and late postmenopause. Hot flashes were present mainly in the early postmenopause stage (38.1%, p ≤ 0.001). Two or more VMS were reported in 23.2% of women in the menopausal transition stage and 29.3% in the early postmenopause stage (p < 0.001). The presence of VMS was associated with different nutritional risk factors (weight, fasting glucose levels, cardiorespiratory fitness, and tobacco use) in women living in the northeast of Mexico.
Abnormal wear patterns in different types of malocclusions
Authors: Smirnova А. A. , Gavrilova O. A. , Fedorova K. V. , Sokolova L. N. , Bobrov D. V. 
Published: June 2022

Relevance. Abnormal tooth wear is a disease characterized by excessive loss of hard tissues of the erupted teeth, unrelated to the physiological process. This disease prevalence appears to have increased in recent decades. The literature often indicates malocclusion as the cause of abnormal tooth wear, though it rarely notes the impact of abnormality type on individual teeth.Purpose. The study aimed to establish the relationship between the abnormality type and the degree and nature of abnormal tooth wear in children at different stages of dentition development.Materials and methods. The study analyzed the examination results of 266 patients aged 8 to 18 years without a history of previous orthodontic treatment. The orthodontic diagnosis was made based on the ICD-10. The patients formed the groups according to the stage of dentition development. The tooth wear index (TWI) (only permanent teeth) evaluated the abnormal tooth wear. The maximum TWI score determined the grade of abnormal tooth wear. The study statistically analyzed the data by StatTech v. 2.5.6, compared the data using the Kruskal – Wallis test (ANOVA) and Pearson chi-square, and made post hoc comparisons using Dunn’s test with Holm adjustment. The prognostic model was developed using the linear regression method.Results. The children and adolescents showed a sufficiently high prevalence of abnormal tooth wear (69.2% had at least one tooth with a tooth wear facet), tooth-wear grade increased with age (correlation coefficient rxy = 0.674, p < 0.001). The risk of abnormal tooth wear in distal and deep occlusion appeared to increase at incisors and canines (p < 0.001), in mesial occlusion - molars and premolars, in open bite – molars (p < 0.001). The combination of distal and deep occlusion led to severe abnormal tooth wear.Conclusion. The study results showed that wear patterns differ in various types of malocclusions. The received data will help to develop effective measures to prevent abnormal tooth wear.
Generalized approach to building computer’s tools of preventive medicine for home using
Authors: Файнзільберг Леонід Соломонович 
Published: June 2022

For early detection and timely correction of imbalances in the body that can lead to the development of various diseases, personalized devices are needed with which one can control the current state of the body at home. The purpose of the article is to develop a universal approach to the construction of such tools and, using examples of solving urgent problems, to demonstrate its effectiveness. A distinctive feature of the proposed approach is that the user at home has the ability to form a training sample of observations of his physiological indicators, according to which two integral characteristics are automatically calculated: the reference result, which is closest to all other observations, and the value, characterizing the average deviation of the results. Personalized diagnostic rules are proposed that ensure an increase in the reliability of decisions about the current functional state of the user and an assessment of the risk of a possible development of pathology. The proposed rules form the basis of original preventive medicine for home use, including the intelligent PHASEGRAPH® electrocardiograph for diagnosing myocardial ischemia at early stages, AI-RHYTHMOGRAPH software applications for determining heart rate variability parameters and AI-ARTERIOGRAPH for integral assessment of properties blood vessels, an intelligent blood pressure monitor that measures the long-term variability in blood pressure between doctor visits, and an intelligent stethoscope for detecting respiratory distress at home. Further development of the proposed approach will make it possible to create personalized means of assessing visual acuity and hearing acuity at home, control of the vestibular apparatus, essential tremor and other means.
Selectivity of dominant surface plasmon polariton modes using thin metal waveguides with grating structures
Authors: Hamashima Kou , Wu Di , Kishimoto Seiya , Inoue Shuichiro , Ohnuki Shinichiro 
Published: June 2022

Abstract
The conversion of incident light to surface plasmon polaritons (SPPs) was verified for a dielectric-metal-dielectric waveguide with a grating structure. The dominant SPP mode with respect to the propagation distance could be selected by adjusting the thickness of the gold film. To realize highly efficient light-to-SPPs conversion, the grating parameters for a realistic length of plasmonic waveguides were optimized using a recently developed numerical technique, FDCFD-FILT. This novel technique is the combination of finite-difference complex-frequency-domain (FDCFD) with fast inversion of laplace transform (FILT) and a powerful tool for designing plasmonic waveguides and investigating propagation characteristics efficiently.
A large unidirectional magnetoresistance in Fe–Sn heterostructure devices
Authors: Shiogai Junichi , Fujiwara Kohei , Nojima Tsutomu , Tsukazaki Atsushi 
Published: June 2022

Abstract
Unidirectional magnetoresistance (UMR) is an attractive magnetic-field sensing technique as it enables us to detect the in-plane direction of the external magnetic field with a single element. However, the UMR amplitude is typically several orders of magnitude smaller than those of other directional magnetoresistances exhibited in ferromagnetic thin films, hindering sensing applications using the UMR. For a directional magnetic sensor using the UMR, an in-depth understanding of the mechanisms of the UMR and its enhancement are highly desirable. In this study, the structural dependence of the UMR in Fe–Sn heterostructure devices is investigated. We find a weak dependence of the UMR on interface configuration in the oxide cap/Fe–Sn heterostructures on various oxide substrates. In contrast, the normalized UMR amplitude is enhanced by a factor of 27 with increasing Fe–Sn layer thickness from 4.0 to 100 nm. These results suggest that the magnetothermal effect dominates the large UMR in the Fe–Sn heterostructure devices.