bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, Optical and A.C Electrical Characteristics of Nanocomposites (Bi2O3/ZnO) Films Prepared by Thermal Evaporation Technique
Authors: Suhail Hassanein S. , Abdulridha Ali R. 
Published: October 2022

Abstract
In this paper, pure bismuth oxide (Bi2O3) and ZnO-doped with a ratio of (0, 0.12, 0.24, 0.36 and 0.48 wt.%) thin films are prepared by thermal evaporation methods under pressure 1×10− 7 bar with a rate of deposition 0.5 nm.s− 1, at ambient temperature on glass substrates (RT) with thickness 50 nm and annealed at temperature 573 K for 2 hours. The phase structures of Bi2O3 (monoclinic) and Bi2O3/ZnO NCPs are confirmed by X-ray diffraction (XRD) investigation. The concentration of ZnO-doping reduces the average crystallite size from 17,35 nm to 8.67 nm. Moreover, using XRD data, the average strain, stress, and dislocation density values are computed. The spectroscopy techniques such as Fourier transform infrared (FT-IR) and scanning electron microscopy with field emission probes were used to examine the structures. The FT-IR results showed no chemical interactions between the (Bi2O3/ZnO) NPs. The results of the field emission-scanning electron microscope (FE-SEM) analysis the (Bi2O3/ZnO) NPs were distributed uniformly throughout. The actually result of optical characteristics for (Bi2O3/ZnO) showed that the absorbance, and absorption coefficient, increase with the increased concentrations of (ZnO). At the same time, the transmittance and energy band gaps were decreased with a rise in concentrations (ZnO) that have a high ability to absorb UV-light. The dielectric characteristics were checked in the frequency range from 100 Hz to 5 MHz. The results of the insulating characteristics showed that the dielectric constant and the dielectric loss of thin films (Bi2O3/ZnO) decreased with increasing frequency. In contrast, they increase when the concentration of (ZnO NPs) increases. The A.C conductivity of the thin films (Bi2O3/ZnO) increases with the frequency and concentration of (ZnO) NPs. Finally, the structural and insulating results the indicated characteristics of the (Bi2O3/ZnO) thin films may be helpful in various nano-electronic devices and sensors.
Weighted Randomn Forest Model for Significant Feature and Disease Progression Prediction
Authors: Rohini M. , Surendran D. 
Published: October 2022

Abstract
In recent studies, several machine learning and deep learning prediction models have been proposed for the early detection and classification of various stages of Alzheimer's Disease (AD). Many years before the actual onset of AD, there occur several structural changes in the brain. These structural brain features can be utilized in learning the disease progression from early stage of disease. The various stages of pathology cause mild cognitive impairment (MCI) from their normal cognition and AD from normal cognition. This chapter intends to develop a random forest learning model that utilizes a relevant subset of predictors to diagnose the progression of the disease. The conversion from normal cognition to MCI is identified at an early stage of the onset of structural brain changes. The importance of existing research works lies in more early identification of significant feature that increases the disease progression and appropriate inventions greatly improves subjects' recovery. The ADNI cross-sectional MRI data were analysed in this study that utilized brain curvature, grey matter white matter density, volume of cortical and sub cortical structures, shape of hippocampus, hippocampal subfield volume, Mini-mental state exam (MMSE), Clinical Dementia Rating (CDR), Estimated Total Intracranial Volume, Normalize Whole Brain Volume, and Atlas Scaling Factor for constructing randomized trees and thus predicting the features that cause the progression of disease stages from MCI to Alzheimer’s disease that causes dementia. This implementation model proved to give robust AD conversion probability and identifying significant features that are sufficient for future clinical inferences.
Emergency digital cholangioscope-assisted one-stage bedside endoscopic stone removal combined with biliary drainage for severe acute cholangitis in intensive care unit: experience from a tertiary Chinese academic hospital
Authors: Zhang Yin-qiu , Liang Yan , Pan Chun , Li Yuanyuan , Liu Yang , Ren Li-Hua , Xu Wei , Shi Rui-Hua , Feng Yadong 
Published: October 2022

Abstract
Background and Aim: To date, Optimal endoscopic management of severe acute cholangitis (SAC) caused by choledocholithiasis remains controversial. The aim of our study was to assess the safety and efficacy of digital cholangioscope-assisted one-stage bedside endoscopic stone removal combined with biliary drainage for patients with SAC in intensive care unit (ICU).
Methods: Patients admitted to the ICU for SAC caused by choledocholithiasis were prospectively included. Initial ICU treatment, including fluid resuscitation, antibiotics and organ support, was administered to improve the patient's conditions, followed by emergency digital cholangioscope-assisted emergency stone removal and biliary drainage at the ICU bedside. Data on treatment effectiveness, procedural complications, mortality, length of hospital stay, and follow-up were collected and analyzed.
Results: From June 2020 to February 2022, twenty patients (8 men and 12 women; mean age, 74.8 ± 12.5 years) were enrolled into the study. Mean APACHE II and SOFA scores at ICU admission were 26.4 ± 6.5 and 12.5 ±3.2, respectively. Besides initial ICU treatment, all patients underwent sucessesfully cholangioscope-assisted one-stage stone removal and biliary drainage within 24 hours of admission, with a mean time of 7.2 ± 4.9 hours. The mean APACHE II and SOFA scores on days 1, 3, and 7 after endoscopic intervention were 21.7 ± 6.5 and 10.6 ±2.9, 17.2 ± 6.8 and 8.4 ±3.0, and 12.7 ± 7.7 and 5.4 ±3.7, respectively (P＜0.001, respectively). Only one adverse event (mild pancreatitis) was reported. The mean antibiotic therapy duration was 12.1 ± 4.4 days. The mean duration of ICU and hospital stay were 9.7 ± 5.0 days and 12.8 ± 4.5 days, respectively. The overall in-hospital mortality was 15% (3/20). During 6 months of follow-up, 2 patients died (one from pneumonia and one from myocardial infarction), and 15 patients remained alive without recurrence of cholangitis and no residual biliary stones were detected on imaging.
Conclusion: This study provides evidence for the feasibility and efficacy of emergency cholangioscope-assisted bedside stone removal combined with biliary drainage in patients with SAC in ICU.
Indications for involuntary hospitalization for refusal of treatment in severe anorexia nervosa: A survey of physicians and Mental Health Care Review Board members in Japan
Authors: Takimoto Yoshiyuki 
Published: October 2022

Abstract
Background
When a patient with anorexia nervosa refuses treatment despite a physically critical condition, the therapist considers involuntary inpatient treatment under the Mental Health Law. However, ethical and practical problems arise from its application. In this study, a survey of treatment providers for eating disorders and psychiatric review board members was conducted regarding indications for involuntary hospitalization under the Mental Health Act for refusal of treatment for anorexia nervosa.
Methods
A survey of 212 physicians affiliated with the Japanese Society for Eating Disorders and 180 members of Mental Health Care Review Boards across Japan was conducted using six vignette cases of patients with anorexia nervosa refusing treatment.
Results
Regardless of the duration of illness or age of the patient, few physicians chose compulsory hospitalization with or without the consent of the family, while the largest number of physicians chose hospitalization for medical care and protection when there was family consent. Among committee members, only hospitalization for medical care and protection was determined to be appropriate when there was family consent. Both hospitalization for medical care and protection, and compulsory hospitalization were deemed appropriate in the absence of family consent. Committee members who adjudged refusal of treatment for anorexia nervosa as self-injurious behavior suggested that compulsory hospitalization was indicated.
Conclusions
When a patient with life-threatening anorexia nervosa refuses inpatient treatment, hospitalization for medical care and protection is actively chosen if the patient's family consents. Mental Health Care Review Board members considered this acceptable. However, if the family does not consent, the physicians did not choose compulsory hospitalization, and the psychiatric review board was divided on this. Consensus was not achieved in this regard.
Upregulated complement receptors correlate with Fc gamma receptor 3A-positive natural killer and natural killer-T cells in neuromyelitis optica spectrum disorder
Authors: Nishiyama Shuhei , Wright Amy Elizabeth , Lotan Itay , Mikami Takahisa , Paul Friedemann , Aoki Masashi , Levy Michael 
Published: October 2022

Abstract
Background and objectives.
Inhibition of terminal complement in neuromyelitis optica spectrum disorder (NMOSD) using eculizumab helps prevent relapses, but the exact mechanism of action of the drug remains unclear. Similarly, genetic variants in the Fc Gamma receptor 3A (FcGR3A), also known as CD16, are correlated with outcomes in NMOSD, but the immune cells expressing those CD16 are unknown. We compared CD16 expression on immune cells modulated by complement activity in Natural Killer (NK) cells and Natural Killer-T (NKT) cells in NMOSD to disease and normal-healthy controls.
Methods.
Peripheral blood cell (PBMC) samples from 45 patients with NMOSD with aquaporin 4 (AQP4)-IgG, 18 disease controls, and 19 normal controls were analyzed for FcGR3A expression and complement receptors in vitro.
Results.
At baseline, the number of NKT cells was increased in NMOSD (p < 0.001), but the proportion that was CD16 positive was lower compared to normal and disease controls (p=0.0012). NK cell count was normal, but the ratio that was CD16 positive was also significantly lower (p < 0.001). In both NK cells and NKT cells from NMOSD, C5 complement receptor expression was much higher than normal and disease controls (p < 0.001 for both). We also evaluated activation markers CD69 and CD83, which were also significantly higher in NK and NKT cells from NMOSD patients. FcGR3A p158 V/V genotype group in NMOSD patients showed decreased NK cell proportion with activation, and fewer CD16 expressed NKT cells than the F/F genotype group.
Discussion.
Our results support an immunopathogenesis model in which complement pathway activation in NK/NKT cells upregulates CD16 expression that binds to antibody/antigen complexes. In the context of NMOSD, these complement-sensitive cells may be responsible for the escalating autoimmune activity.
Revealing a gap in the clinical competence of nursing staff in nursing homes: A cross-sectional study with the Ms. Olsen test
Authors: Vikström-Dahl Irén , Bing-Jonsson² Pia Cecile , Rauhala³ Auvo , Fagerström Lisbeth 
Published: October 2022

Abstract
Background: The elderly population and their life expectancy have increased, and current long-term care (LTC) for frail older people has limited capabilities because of many diseases among the patients. The nursing staff needs to have a certain level of clinical competence to identify diseases at an early stage and to assess and provide good nursing care to patients with different diseases. In Finland, nursing care in nursing homes is based on evidence-based and high-quality nursing care. However, earlier inspections by the National Supervisory Authority for Welfare and Health showed many discrepancies between the nursing staff’s clinical competence and adequate and continuous education.
Aim: This study aimed to explore nursing staff, i.e the clinical competence and decision-making skills of registered and practical nurses in nursing homes for older people in Finland and to analyse the association between nurses’ clinical competence and fundamental background factors
Methods: We conducted a cross-sectional study of 337 participants in 50 nursing homes in the western part of Finland. The instrument used was the validated Ms. Olsen test, an extraction of NOP-CET. Statistical analyses were conducted with descriptive statistics and correlations and a cut-off for clinical competence.
Results: The clinical competence test, Ms Olsen test was used in Finland for the first time to evaluate the nursing staffs´ clinical competence in nursing homes. This study disclosed that nursing staff showed worrisome limitations in their clinical competence in the LTC in the western part of Finland and the Ms. Olsen test revealed that only one-fourth of the RNs and a third of the PNs passed the cut-off for the clinical competence test. In the self-evaluation, almost all (98.9%) of the participants evaluated themselves as having pretty good to very good clinical competence, which differed remarkably from the results of the Ms. Olsen test. The Finnish Current Care Guidelines were used on a daily basis by 7.4% and weekly by 30%. A statistically significant moderate correlation was found for the nursing staff between Swedish as a working language and mother tongue and the score for clinical competence. No statistically significant correlations were found between the nursing staff’s clinical competence and their use of the Finnish Current Care Guidelines. Previous research has argued that continuous education will enhance nursing staff’s status and clinical competence; however, according to our study, continuous education was not prioritised.
Prognostic Implication of Stress Hyperglycemia in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
Authors: Wang Man , Su Wen , Cao Ning , Chen Hui , Li Hong-Wei 
Published: October 2022

AbstractBackground Previous studies have reported that stress hyperglycemia is associated with adverse outcomes in hospitalized patients. We aimed to investigate the association between a novel index of stress hyperglycemia and the risk of mortality in acute coronary syndrome (ACS) patients who underwent percutaneous coronary intervention (PCI). Methods This cohort study consisted of 5,316 ACS patients who underwent PCI from the Cardiovascular Center Beijing Friendship Hospital Database Bank (CBDBANK) from January 2013 to January 2021. Stress hyperglycemia was defined by the glucose/glycated albumin (GA) ratio, calculated as admission fasting plasma glucose divided by GA. The patients were divided into four groups according to glucose/GA ratio quartiles (Q1-Q4). Cox proportional hazards regression and restricted cubic spline were used to evaluate the association between glucose/GA ratio and all-cause and cardiovascular (CV) mortality. Results During a median follow-up of 4.0 years, 322 (6.1%) all-cause deaths and 180 (3.4%) CV deaths were reported. After adjustment for potential confounders, the risk of all-cause mortality increased in both the lowest (HR, 1.43; 95% CI, 1.01–2.01) and highest (HR, 1.53; 95% CI, 1.05–2.21) glucose/GA ratio quartiles as compared that of Q2. The restricted cubic splines showed that the association between glucose/GA ratio and all-cause mortality was J-shaped after full adjustment (Pnonlinear= 0.010). Similar results were observed for CV deaths. In subgroup analyses, the J-shaped relationship was only significant in patients with diabetes mellitus. Conclusion In ACS patients undergoing PCI, both low and high glucose/GA ratio levels were associated with an increased all-cause and CV mortality, especially in those with diabetes mellitus.
Impact of obesity on Ventriculo-Arterial Interaction in patients after Coarctation of Aorta repair
Authors: Bansal Prerna B , Zaidi Ali N , Bansal Neha , Stern Kenan , Mahgerefteh Joseph 
Published: October 2022

Abstract
Survival of patients after repair of coarctation of Aorta (CoA) has improved significantly over the decades, but patients have decreased life expectancy as compared to the general population. This has been attributed to increased hypertension, cerebrovascular disease and coronary artery disease. There has also been an increasing concern of overweight and obesity in patients with adult congenital heart disease. While there have been studies looking at the impact of long-term hypertension on myocardial performance and outcomes in this population, this study aims to assess the impact of obesity in these patients on their myocardial performance. Ventriculo-arterial coupling is used as a measure of myocardial performance which reflects the interaction between cardiac contractility and arterial elastance. Patients after CoA repair are known to have hypertension affecting the arterial elastance. Obesity affects cardiac contractility as well. This study demonstrated that in a group of young patients after CoA repair, Body Mass Index (BMI) has a relationship with Left Ventricular (LV) contractility and myocardial performance. This relationship was independent of blood pressure. BMI itself was not seen to affect the determinants of diastolic function in this study, suggesting that LV contractility may be affected before one can notice a change in the diastolic function secondary to BMI.
Identification of ADP-ribosylation factor 6 as the cellular target of withangulatin A against TNBC cells by ferroptosis
Authors: Sun Dejuan , Yang Yueying , Liu Yang , Ma Xiaoxin , Li Hua , Chen Lixia 
Published: October 2022

Abstract
Purpose
Effective anticancer therapy can be achieved by regulating ADP-ribosylation factor 6 (ARF6) activation, but its biological roles are still challenging and few effective compounds against ARF6 have been identified. WA exerts the anti-proliferative effects on MDA-MB-231 cells. However, its molecular targets and unexplored mechanisms remain elusive. In the present study, our objective was to develop novel therapeutic strategies to improve therapy effectiveness.
Methods
Using experiment approaches, including CCK8, MDC assay, colony formation assay, immunoblotting and immunohistochemistry, we verified the therapeutic effects of Withangulatin A (WA). ARF6 was identified as the potential target of WA by human proteome microarray analysis. The binding of WA and ARF6 was validated by Microscale Thermophoresis assay, immunoprecipitation, immunofluorescence and ARF6 GTP pulldown assay. The binding mode was analyzed by molecular docking and site-directed mutagenesis.
Results
WA potently inhibited the activation of ARF6, which regulated the anticancer effect of WA in triple negative breast cancer (TNBC). Mechanistically, the ferroptosis mediated by WA was found through statistical analysis of genomics. Furthermore, WA can regulate ferroptosis by targeting ARF6, thus affecting the proliferation of TNBC cells. Particularly, Gln67 and His76 may be the key amino acid residues to influence the binding of WA to ARF6. Interestingly, the synergistic effects of WA and 3-MA sensitized TNBC cells to ferroptosis induction.
Conclusion
Our study identified the cellular target of WA and revealed the unrecognized function of ARF6, and it would provide a promising alternative therapy for triple negative breast cancer.
Skin involvement: a harbinger of worse prognosis in patients with sepsis
Authors: Pulido-Pérez Ana , Bergón-Sendín Marta , Suárez-Fernández Ricardo , Sánchez-Carrillo Carlos , Rosell-Díaz Ángel Manuel , Nieto-Benito Lula , Barchino-Ortiz Lucía , Muñoz Patricia , Bouza Emilio 
Published: October 2022

Abstract
Skin involvement can occur at the beginning of a septic episode (primary skin and soft tissue infections) or during its progression (secondary or metastatic skin lesions), making skin a useful accessible tissue in the study of septic patients. The objective of this study was to determine the overall prevalence of sepsis-related skin findings and evaluate their possible prognostic value. A retrospective, single-center, study of septic patients with documented bloodstream infections admitted in a tertiary hospital during 2019 was carried out. Unselected samples of 320 episodes of sepsis from 265 patients were included. Skin lesions were documented in 83 septic episodes from 69 patients (25.9%). Skin involvement was more frequently associated with bloodstream infections caused by Staphylococcus aureus (p = 0.0001), coagulase-negative staphylococci (p = 0.036), and Pseudomonas aeruginosa (p = 0.005). Mean hospital stay (37.58 days vs 27.82 days, p = 0.023) and sepsis-related mortality (18.1% vs 11.0%, p = 0.024) were higher in patients with skin lesions than in individuals without them. Our results suggest that skin involvement (primary and/or secondary) is an unfavorable indicator in the evolution of septic patients with bloodstream infections. Thorough examination of the skin is recommended in the routine evaluation of septic patients, whether or not the origin of the infection is known.
Scale Transfer in 1849 Heinrich Schwabe to Rudolf Wolf
Authors: Bhattacharya Shreya , Lefevre Laure , Hayakawa Hisashi , Jansen Maarten , Clette Frederic 
Published: October 2022

Abstract
The focus of this study is to reveal the reason behind a scale problem detected around1849 in the historical version of the International Sunspot Number Series, i.e. version1 (Leussu et al, Astronomy and Astrophysics, 559, A28, 2013; Friedli, Solar Phys.291,2505, 2016). From 1826 to 1848 Heinrich Schwabe’s observations were consideredprimary by Rudolf Wolf, and a shift of primary observer from Schwabe to Wolf in1849 seems to have led to an inconsistency in the Sunspot Number series. In thisstudy we benefited from various datasets, the most important being Schwabe’s rawcounts from the Mittheilungen (Prof. Wolf’s Journals) that have been digitised at theRoyal Observatory of Belgium between 2017 and 2019. We provide a robust quantification of the detected problem by using classic algebraic calculations but alsodifferent methods such as a method inspired by Lockwood et al (Journal of Geophysical Research (Space Physics), 119(7), 5172, 2014), hence assigning a modern k-factorto Schwabe’s observations before 1849. We also assess the implications of this 1849 inconsistency on the International Sunspot Number series (Versions 1 and 2) beforeand after 1849.
Influence of ultraviolet radiation and temperature on the phototactic response of tropical species of stingless bees
Authors: Ramos Davi de L. , Mota² Theo R.P. , Bustamante¹ Mercedes M.C. , Pires³ Carmen S.S. 
Published: October 2022

Abstract
We evaluated how ultraviolet (UV) and green light in the solar spectrum, as well as temperature, affected the proportion and latency of phototactic choice for three distinct stingless bee species within a Y-shaped maze. We showed that all studied bee species chose the edges with a higher incidence of solar UV light more often and with shorter choice latencies than other edges. Under conditions of low UV at both ends of the maze, neither a higher proportion of green nor a higher total light intensity impacted the phototactic orientation of bees towards a particular maze arm. The proportion of choice in Frieseomelitta varia did not change in response to an increase in temperature, and remained high with increased UV light. These results indicate that UV light was an important component of the phototactic response of the tropical bee species studied, and this should be considered when using them to provide pollination services in environments with a low incidence of UV light, as is prevalent in greenhouses. Moreover, the phototactic behaviour observed in F. varia, even under heat stress conditions, suggested that this species was suitable for use as pollinators in greenhouses.