bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Approaches in the Synthesis of 5-Arylidene-2,4-thiazolidinedione
Derivatives Using Knoevenagel Condensation
Authors: Maity Tapan Kumar , Paul Abhik , Maji Avik , Sarkar Arnab , Saha Sanjukta , Janah Pritha 
Published: April 2022

Abstract:
5-Arylidene-2,4-thiazolidinedione (5-A-TZD) is an emerging precursor molecule in medicinal
chemistry for discovering multifunctional therapeutic agents. For synthesizing this precursor
molecule, Knoevenagel Condensation (KC) is one of the most excellent tools in modern organic
chemistry. The 5-A-TZD framework has a variety of therapeutic functions such as antidiabetic, anticancer,
antimicrobial, and anti-inflammatory. As a result, several approaches and methods of KC
have been established for the synthesis of this multifunctional precursor. However, the use of highly
corrosive catalysts, prolonged reaction times, by-products formation, and poor product yields are the
main drawbacks in 5-A-TZDs synthesis via KC. Therefore, several authors have been successfully
established fast, effective, and environmentally sustainable protocols of KC using organic catalysts,
inorganic catalysts, heterogeneous solid catalysts, ionic liquids (ILs), and bio-catalysts to synthesize
5-A-TZD derivatives with high conversion yield and selectivity. In this review, we have summarized
the recent approaches for synthesizing 5-A-TZDs via KC and their therapeutic application as a precursor
molecule in medicinal chemistry.
Overview of the Large Bowel Assessment using Magnetic Resonance Imaging: Different Techniques for Current and Emerging Clinical Applications
Authors: Cicero Giuseppe , Ascenti Giorgio , Blandino Alfredo , Booz Christian , Vogl Thomas J. , Trimarchi Renato , D'Angelo Tommaso , Mazziotti Silvio 
Published: April 2022

Abstract:Radiological assessments of the small and large bowel are essential in daily clinical practice. Over X-ray plain films and ultrasound, cross-sectional techniques are considered the most comprehensive imaging modalities. "Cross-sectional techniques" refers to CT and MRI, as stated in the following sentence. In fact, computed tomography and magnetic resonance imaging take great advantage of the three-dimensional appraisal and the extensive evaluation of the abdominal cavity, allowing intestinal evaluation as well as detection of extra-intestinal findings. In this context, the chief advantage of computed tomography is the fast scan time, which is crucial for emergency cases. Nonetheless, it is undeniably impaired using ionizing radiation. As the awareness of radiation exposure is a topic of increasing importance, magnetic resonance imaging is not only becoming a mere alternative but also a primary imaging technique used in assessing intestinal diseases. Specifically, the evaluation of the large bowel through MRI can still be considered relatively uncharted territory. Although it has demonstrated superior accuracy in the assessment of some clinical entities from inflammatory bowel disease to rectal carcinoma, its role needs to be consolidated in many other conditions. Moreover, different technical methods can be applied for colonic evaluation depending on the specific disease and segment involved. This article aims to provide a thorough overview of the techniques that can be utilized in the evaluation of the large bowel and a discussion on the major findings in different colonic pathologies of primary interest.
The Effect of Association between Fat Mass and Obesity-associated Gene
Polymorphism (rs9939609) on the Body Composition of Older People: A
Systematic Review
Authors: Trevisano Rebeca Gonçalves , Gregnani Marcos Fernandes , de Azevedo Bruna Cestari , de Almeida Sandro Soares 
Published: April 2022

Background:
The aging population is growing faster than any other age group worldwide.
Associated with aging, the prevalence of overweight and obesity is a potential risk factor for
the development and aggravation of numerous pathologies. A genetic factor often associated with
obesity is the fat mass and obesity-associated (FTO) (rs9939609) gene polymorphism, which has
been extensively investigated in children, young, and adults. However, few studies have been carried
out on the older population. This review aimed to verify the influence of the FTO (rs9939609)
gene polymorphism on the body composition of the older population.

Methods:
We conducted a systematic review and meta-analysis on PubMed, Scielo, and LILACS
databases. Statistical analysis for meta-analysis was performed using mean values of Body Mass
Index (BMI) and standard deviations.

Results:
The results did not show significant differences between FTO genotypes and BMI values
(-0.32, 95% CI -0.45 to -0.19, I2 = 0%, p = 0.52). However, 59% of the studies identified some influence
on body composition, obesity, or comorbidities.

Conclusion:
Few publications verify FTO polymorphism effects on specific groups of the older
population, suggesting a reduction in the influence of this gene on the BMI with advancing age.
However, we believe that more controlled studies in older populations should be performed.
LTE Modulation and Coding Schemes for 6G Networks
Authors: Venkataramanan V. , Dehiya Ravleen Kaur , Vora Anshul , Shah Aman , Nafre Aishwarya , Prachi Gandhi 
Published: April 2022

Background:
Long Term Evolution (LTE) is the fourth generation (4G) mobile communication technology developed by the 3rd Generation Partnership Project (3GPP). In comparison to previous generations of cellular systems, LTE incorporates several innovative technologies. These innovative technologies are used to increase spectrum efficiency and data speeds, as envisioned by designers

Methods:
This study provides a comprehensive investigation of orthogonal frequency division multiple access and Single carrier frequency division multiple access transmission model and investigate physical layer performance of LTE system using MATLAB – Simulink Environment.

Results:
By providing spectrum flexibility, the SC-FDMA-OFDMA 16 QAM with AWGN Channel Transmission model achieves a higher outcome and has a packet loss rate of 0%. The numerical evaluation is used to illustrate the trade-off between loss of capacity in the time and frequency domains.

Conclusion:
SC-FDMA has a lower multipath propagation rate and peak to average power ratio than OFDM; therefore, multipath must be eliminated to make it more efficient. The final section of this study contains a full description of the techniques required in simulating a simple communication model.
TREN ANGKA PUTUS SEKOLAH PADA SEKOLAH MENENGAH KEJURUAN (SMK) SELAMA 10 TAHUN KE DEPAN DI DAERAH ISTIMEWA YOGYAKARTA
Authors: Hati Malisa Bunga 
Published: April 2022

AbstrakPenelitian ini bertujuan untuk: 1. Mengetahui tren angka putus sekolah jenjang SMK selama 10 tahun ke depan di DIY; 2. Mengetahui kebijakan dan program yang diupayakan pemerintah untuk mengurangi angka putus sekolah di DIY. Penelitian ini menggunakan pendekatan kuantitatif deskriptif dengan metode analisis data sekunder dan wawancara. Data sekunder berasal dari Dinas Pendidikan Pemuda dan Olahraga DIY. Analisis data menggunakan Analisis Tren dengan persamaan Ẏ = 𝑎 + 𝑏𝑥. Hasil penelitian adalah: 1. Tren APtS jenjang SMK selama 10 tahun ke depan di DIY pada anak laki-laki mengalami kecenderungan menurun dengan persentase mencapai 0,92% dan telah memenuhi Standar Pelayanan Minimal Bidang Pendidikan, sedangkan pada anak perempuan mengalami kecenderungan meningkat dengan persentase mencapai 2,12% dan belum mampu memenuhi Standar Pelayanan Minimal Bidang Pendidikan; dan 2. Kebijakan dan program untuk mengurangi APtS jenjang SMK di DIY yaitu kebijakan pembiayaan pendidikan melalui program BOS dan kebijakan serta program dengan inovasi di masing-masing daerah. Kata Kunci: Tren, Angka Putus Sekolah, Sekolah Menengah Kejuruan, DIY. AbstractThis study aims to: 1. Determine the trend of vocational school dropout rates for the next 10 years in DIY; 2. Knowing the policies and programs being pursued by the government to reduce the number of dropouts in DIY. This research uses a descriptive quantitative approach with secondary data analysis and interview methods. Secondary data came from the Department of Youth Education and Sports DIY. Data analysis uses Trend Analysis with the equation Ẏ = 𝑎 + 𝑏𝑥. The results of the study are: 1. The trend of APtS Vocational School for the next 10 years in DIY in boys has a downward trend with a percentage reaching 0,92% and has met the Minimum Service Standards in Education, while girls have a tendency to increase with a percentage reached 2,12% and have not been able to meet the Minimum Service Standards in Education; and 2. Policies and programs to reduce the APtS of SMK levels in DIY, namely the education financing policy through the BOS program and policies and programs with innovation in the region. Keywords: Trends, Dropout Rates, Vocational High Schools, DIY.
Enablers and Barriers to HIV Services for Gay and Bisexual Men in the COVID-19 Era: Fusing Data Sets from Two Global Online Surveys Via File Concatenation With Adjusted Weights
Authors: Ayala George , Arreola Sonya , Howell Sean , Hoffmann Thomas J , Santos Glenn-Milo 
Published: April 2022

Background
Gay and bisexual men are 26 times more likely to acquire HIV than other adult men and represent nearly 1 in 4 new HIV infections worldwide. There is concern that the COVID-19 pandemic may be complicating efforts to prevent new HIV infections, reduce AIDS-related deaths, and expand access to HIV services. The impact of the COVID-19 pandemic on gay and bisexual men’s ability to access services is not fully understood.

Objective
The aim of this study was to understand access to HIV services at the start of the COVID-19 pandemic.

Methods
Our study used data collected from two independent global online surveys conducted with convenience samples of gay and bisexual men. Both data sets had common demographic measurements; however, only the COVID-19 Disparities Survey (n=13,562) collected the outcomes of interest (HIV services access at the height of the first COVID-19 wave) and only the Global Men’s Health and Rights Survey 4 (GMHR-4; n=6188) gathered pre-COVID-19 pandemic exposures/covariates of interest (social/structural enablers of and barriers to HIV services access). We used data fusion methods to combine these data sets utilizing overlapping demographic variables and assessed relationships between exposures and outcomes. We hypothesized that engagement with the gay community and comfort with one’s health care provider would be positively associated with HIV services access and negatively associated with poorer mental health and economic instability as the COVID-19 outbreaks took hold. Conversely, we hypothesized that sexual stigma and experiences of discrimination by a health care provider would be negatively associated with HIV services access and positively associated with poorer mental health and economic instability.

Results
With 19,643 observations after combining data sets, our study confirmed hypothesized associations between enablers of and barriers to HIV prevention, care, and treatment. For example, community engagement was positively associated with access to an HIV provider (regression coefficient=0.81, 95% CI 0.75 to 0.86; P<.001), while sexual stigma was negatively associated with access to HIV treatment (coefficient=–1.39, 95% CI –1.42 to –1.36; P<.001).

Conclusions
HIV services access for gay and bisexual men remained obstructed and perhaps became worse during the first wave of the COVID-19 pandemic. Community-led research that utilizes novel methodological approaches can be helpful in times of crisis to inform urgently needed tailored responses that can be delivered in real time. More research is needed to understand the full impact COVID-19 is having on gay and bisexual men worldwide.
Factors Affecting Human Papillomavirus Vaccination in Men: Systematic Review
Authors: Shin Hyunjeong , Jeon Songi , Cho Inhae , Park HyunJi 
Published: April 2022

Background
Despite the high risks associated with human papillomavirus (HPV), the HPV vaccination rate of men is far lower than women. Most previous review studies have focused on female vaccination and related affecting factors. However, previous studies have reported that the factors affecting HPV vaccination differ by gender.

Objective
The aim of this review was to identify the factors affecting HPV vaccine initiation in men through a systematic review approach.

Methods
A literature review was conducted across 3 central electronic databases for relevant articles. A total of 30 articles published between 2013 and 2019 met the inclusion criteria and were reviewed in this study.

Results
In total, 50 factors affecting HPV vaccination in men were identified, including 13 sociodemographic factors and social structure factors, 12 belief-related variables, 4 family factors, 4 community factors, 14 variables related to needs, and 3 environmental factors.

Conclusions
To increase HPV vaccination rates in men, strategies targeting young males and their families should consider frequent visits to or contact with health care providers so that health care professionals can provide recommendations for HPV vaccination.
Confronting the difficult challenges of academic reading of Indonesian graduate students through the lens of self-efficacy and metacognitive strategies
Authors: Sulistyawati Elizabeth Emmanuela , Mbato Concilianus Laos 
Published: April 2022

Students’ self-efficacy and reading strategies have been globally investigated. However, there is a limited number of studies in Indonesia that examined the correlation between self-efficacy and metacognitive reading strategies. This study aimed to find out the correlation between students’ self-efficacy and metacognitive reading strategies, their perceptions of self-efficacy, and their metacognitive strategies. This mixed-method study used a Likert scale questionnaire and interview to collect the data. From the quantitative data analysis, the results show that there is a positive correlation between students’ self-efficacy and metacognitive reading strategies of the Indonesian graduate students, which was significant at the 0.01 level (r = .970, n = 33). The students used the most metacognitive strategies in every stage of reading to a high degree. They also shared different strategies used when students encountered difficulties (St. 5, M=4.12). From the qualitative data analysis, the students applied four different strategies for each reading stage. They also shared the different reasons concerning the use of metacognitive reading strategies. This current study offers one major implication. Since the students’ levels of self-efficacy are affected by extrinsic aspects, teachers need to develop a professional identity that enables them to support students in developing self-beliefs and metacognitive reading strategies.
DISEÑO E IMPLEMENTACIÓN DE UN PROCESO AUTOMATIZADO PARA CURADO DE MATERIALES COMPUESTOS
Authors: Carranco Herrera Andrés Marcelo 
Published: April 2022

Una de las áreas prioritarias para la industria moderna es disminuir la dependencia tecnológica, por ello es necesario plantear soluciones a las necesidades que se presentan día a día una de ellas es la automatización de procesos. Por ello, se plantea el diseño de un proceso de curado automatizado de materiales compuestos para contribuir a la investigación en materiales compuestos. Para alcanzar mejores propiedades mecánicas que requiere un producto aeronáutico a fin de soportar las cargas a las que se verá sometido el material durante una operación de vuelo es fundamental lograr un buen desempeño del proceso el curado. Para el desarrollo del sistema se utilizó una metodología conceptual planteando diversas alternativas de solución orientando el esfuerzo a bosquejar, dimensionar el equipo y elegir el mejor concepto del producto. Una vez definido el concepto, se materializó el sistema precisando los subsistemas de control de vacío que permite una redistribución de la matriz en las fibras de refuerzo del material compuesto durante el curado; el subsistema de tratamiento térmico se encarga de incrementar la temperatura del composite a fin de alcanzar las propiedades mecánicas necesarias. La automatización del proceso de curado de materiales compuestos genera óptimos resultados, consiguiendo un equipo versátil, útil y robusto. Finalmente, al emplear el equipo para el propósito que fue diseñado se evidencia la eficiencia que se tiene en el curado de materiales compuestos de manera automatizada frente a un curado manual a temperatura ambiente.
Analisis Yuridis Peran Kepolisian Dalam Penanganan Tindak Pidana Pemilihan Umum Di Kota Palopo
Authors: Pabbu Amiruddin , Irpan Irpan 
Published: April 2022

Penelitian Ini bertujuan untuk mengetahui sejauh mana peran kepolisian dalam penanganan pelanggaran pemilu di Kota Palopo dan untuk mengetahui faktor apa saja yang menghambat dalam penanganan pelanggaran pemilu di Kota Palopo. Metode Penelitian yang di gunakan yakni penelitian hukum normatif dengan pendekatan penelitian meliputi pendekatan perundang–undangan (statute approach) dan pendekatan Konseptual (conceptual approaach). Teknik Analisis data dianalisis secara kualitatif, kemudian dari hasil analisis tersebut akan dituangkan secara deskriptif. Hasil penelitian ini menunjukkan bahwa peran polisi dalam menegani tindak pidana pemilihan kepala daerah yaitu menganalisa, mengfilter dan menentukan apakah pelanggaran tersebut merupakan pelanggaran tindak pidana pemilu atau pelanggaran administrasi pemilhan umum kepala daerah. Kendala yang di hadapi polisi dalam menangani laporan tindak pidana pelanggaran pemilu diantaranya bukti dalam proses peyidikan dan penyelidikan yang membuat kepolisian lambat dan tidak adanya saksi maupun orang yang mau memberikan kesaskian terhadap laporan tersebut, danan pihak kepolisian juga sangat terbebani dengan singkatnya waktu yang di amanahkan oleh undang-undang untuk melakukan proses penanganan laporan pelanggaran tindak pidana pemilu.
Analisis Yuridis Pelaksanaan Perjanjian Kredit Dengan Jaminan BPKB Antara Nasabah dan PT. Permodalan Nasional Madani (Studi Pt Pnm Sulbar)
Authors: Basir Abd , Hamid Asba 
Published: April 2022

Penelitian Ini bertujuan untuk Mengetahui Mekanisme perjanjian kredit Antara nasabah dan Pt.Permodalan Nasional Madani danuUntuk mengetahui kendala dalam pelaksanaan perjanjian kredit antara nasabah dan Pt. Permodalan Nasional Madani. Metode Penelitian yang di gunakan yakni penelitian hukum normatif dengan pendekatan penelitian meliputi pendekatan perundang–undangan (statute approach) dan pendekatan Konseptual (conceptual approaach). Teknik Analisis data dianalisis secara kualitatif, kemudian dari hasil analisis tersebut akan dituangkan secara deskriptif. Hasil penelitian ini menunjukkan bahwa Pelaksanaan perjanjian kredit antara nasabah dan PT. Permodalan Nasional Madani dengan jaminan Buku Pemilik Kendaraan Bermotor (BPKB) dilakukan dengan beberapa cara atau beberapa tahap yaitu, dengan mengajukan permohonan terlebih dahulu kemudian akan di proses oleh PT. Permodalan Nasional Madani, apabila calon nasabah yang ingin meminjam tidak mengajukan permohonan terlebih dahulu maka keinginannya untuk meminjam tersebut tidak dapat diproses lebih lanjut, setelah mengajukan permohonan kepada PT. Permodalan Nasional Madani dan diproses oleh PT. Permodalan Nasional Madani melalui proses yang panjang maka akan diteruskan pada tahap penanda tanganan kontrak, apabila perjajian telah mendapatkan kata sepakat dari pada para pihak maka barulah bisa di lakukan pencairan pada pinjaman tersebut. Dalam pelaksanaan perjanjian antara nasabah dan PT. Permodalan Nasional Madani dengan jaminan BPKB motor, banyak sekali kendala. Dimana adanya wanprestasi yang dilakukan oleh nasabah, salah satu diantaranya adalah menggunakan modal yang dipinjamkan oleh PT. Permodalan Nasional Madani tidak digunakan untuk usaha melainkan untuk keperlun sehari-hari dan lain sebagainya, sehingga hal tersebut membuat usahanya kurang lancar dan bahkan menjadi macet, nasabah yang seperti ini dapat di kategorikan peminjam yang bermasalah.
DINAMIKA BATASAN USIA PERKAWINAN DI INDONESIA: Kajian Psikologi Dan Hukum Islam
Authors: Yusuf Yusuf 
Published: April 2022

Article 7 of Law No. 1 of 1974 established that the minimum age of marriage for men is 19 years old and women 16 years old. The regulation was amended through Law No. 16 of 2019 which sets the minimum threshold for marriage for men and women to be married is a minimum age of 19 years. Changes to the minimum marital boundaries are of course intended that the age of marriage becomes an inward part with the goal of marriage, animating the basis of marriage and it is hoped that in the future it will be able to minimize conflicts in the household. Unfortunately, the marriage age limit still causes dynamics. By using library research, there are three results of this study. First, Islamic law does not specify a minimum age for a bride and groom who will carry out the marriage. The foqoha’ differ in opinion in determining the age of maturity of a person in carrying out marriage but has the same goal, namely to establish goals rather than Islamic law. Second, psychologists think that the age of adulthood (adolescent) is right in carrying out marriage, that is someone who is 21 years old and so on. Third, the consequences of premature marriages will arise legal problems, biological problems, psychological problems, social problems, and problems of deviant sexual behavior.
Pasal 7 Undang-Undang No. 1 tahun 1974 menetapkan bahwa usia minimal pernikahan bagi pria adalah umur 19 tahun dan wanita umur 16 tahun. Aturan tersebut dirubah melalui Undang-Undang No. 16 tahun 2019 yang menetapkan batas minimal menikah bagi laki-laki dan perempuan yang akan menikah adalah minimal di usia 19 tahun. Perubahan batasan minimal perkawinan ini tentu dimaksudkan bahwa usia perkawinan menjadi bagian yang inhern dengan tujuan perkawinan, menjiwai dasar perkawinan dan diharapkan kedepanya nanti dapat meminimalisir konflik dalam rumah tangga. Sayangnya, batasan usia perkawinan tersebut masih menimbulkan dinamika. Dengan menggunakan penelitian pustaka, ada tiga hasil penelitian ini. Pertama, hukum Islam tidak menetapkan minimal usia bagi calon mempelai yang akan melaksanakan perkawinan. Para foqoha’ berbeda pendapat dalam menentukan usia kedewasaan seseorang dalam melaksanakan sebuah perkawinan, tetapi memiliki tujuan sama, yaitu menegakan tujuan dari pada Hukum Islam. Kedua, para ahli psikologi berpendapat bahwa usia dewasa (edolesen) tepat dalam melaksanakan perkawinan, yaitu seseorang yang berumur 21 tahun dan seterusnya. Ketiga, akibat daripada perkawinan yang prematur akan timbul masalah hukum, masalah biologis, masalah psikologis, masalah sosial, dan masalah prilaku seksual menyimpang.