bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parietal bone thickness for predicting operative transfusion and blood loss in patients undergoing spring-mediated cranioplasty for nonsyndromic sagittal craniosynostosis
Authors: Villavisanis Dillan F. , Cho Daniel Y. , Shakir Sameer , Kalmar Christopher L. , Wagner Connor S. , Cheung Liana , Blum Jessica D. , Lang Shih-Shan , Heuer Gregory G. , Madsen Peter J. , Bartlett Scott P. , Swanson Jordan W. , Taylor Jesse A. , Tucker Alexander M. 
Published: January 2022

OBJECTIVE
Variables that can predict outcomes in patients with craniosynostosis, including bone thickness, are important for surgical decision-making, yet are incompletely understood. Recent studies have demonstrated relative risks and benefits of surgical techniques for correcting head shape in patients with nonsyndromic sagittal craniosynostosis. The purpose of this study was to characterize the relationships between parietal bone thickness and perioperative outcomes in patients who underwent spring-mediated cranioplasty (SMC) for nonsyndromic sagittal craniosynostosis.

METHODS
Patients who underwent craniectomy and SMC for nonsyndromic sagittal craniosynostosis at a quaternary pediatric hospital between 2011 and 2021 were included. Parietal bone thickness was determined on patient preoperative CT at 27 suture-related points: at the suture line and at 0.5 cm, 1.0 cm, 1.5 cm, and 2.0 cm from the suture at the anterior parietal, midparietal, and posterior parietal bones. Preoperative skull thickness was compared with intraoperative blood loss, need for intraoperative transfusion, and hospital length of stay (LOS).

RESULTS
Overall, 124 patients with a mean age at surgery ± SD of 3.59 ± 0.87 months and mean parietal bone thickness of 1.83 ± 0.38 mm were included in this study. Estimated blood loss (EBL) and EBL per kilogram were associated with parietal bone thickness 0.5 cm (ρ = 0.376, p < 0.001 and ρ = 0.331, p = 0.004; respectively) and 1.0 cm (ρ = 0.324, p = 0.007 and ρ = 0.245, p = 0.033; respectively) from the suture line. Patients with a thicker parietal bone 0.5 cm (OR 18.08, p = 0.007), 1.0 cm (OR 7.16, p = 0.031), and 1.5 cm (OR 7.24, p = 0.046) from the suture line were significantly more likely to have undergone transfusion when controlling for age, sex, and race. Additionally, parietal bone thickness was associated with hospital LOS (β 0.575, p = 0.019) when controlling for age, sex, and race. Patient age at the time of surgery was not independently associated with these perioperative outcomes.

CONCLUSIONS
Parietal bone thickness, but not age at the time of surgery, may predict perioperative outcomes including transfusion, EBL, and LOS. The need for transfusion and EBL were most significant for parietal bone thickness 0.5 cm to 1.5 cm from the suture line, within the anticipated area of suturectomy. For patients undergoing craniofacial surgery, parietal bone thickness may have important implications for anticipating the need for intraoperative transfusion and hospital LOS.
The purpose, tasks and functions of the National Police of Ukraine staffing
Authors: Harbuziuk K. H. 
Published: January 2022

Based on the analysis of scientific views and current legislation, it was found that the purpose of staffing the National Police of Ukraine is to form a staff of qualified professionals capable of performing police tasks properly within certain job functions and in accordance with the specific needs of this central executive body. It is emphasized that the goal of staffing is achieved through solving a certain range of tasks.
It is proved that the task, in the context of this issue, is most appropriate to understand as certain predetermined results of the activities of the authorized personnel of the police, the solution of which should lead to the achievement of a common goal. It is substantiated that the direction of the above tasks is most appropriate to divide into the following: a) prognostic and planned (study of the demand of the National Police for certain specialists, planning ways to meet it); b) recruitment and training (involvement of persons who have the ability and desire to work in the National Police, providing their training); c) accompanying tasks (providing conditions for maintaining and improving the quality of professional activity of employees); d) social security (proper provision of social guarantees for employees of the National Police); e) organizational, covering the tasks of proper documentation of enrollment in the National Police, training and postgraduate education and completion of employment in the National Police.
It is argued that the tasks are inextricably linked to the staffing functions of the National Police of Ukraine. The analysis of scientific views of scientists allowed to state that the latter should be understood as the main activities of authorized entities, including identifying the needs of the National Police in certain qualified personnel, involving people in the National Police, competitive selection of candidates for service in the National Police bodies, organization of training, support of professional skills of employees of the National Police of Ukraine by directing them to the necessary types of postgraduate education, as well as the organization of career growth based on quality assessment of employees of the National Police of Ukraine, social protection, educational activities that include the application of disciplinary measures of encouragement and punishment, dismissal from the police service and socio-economic support of persons dismissed from the National Police, in accordance with the requirements of current legislation.
The concept of "void contract" in public procurement
Authors: Zaitsev O. L. , Shyshka O. R. 
Published: January 2022

The way of origin and consolidation in the public procurement procedure of the institute of a void contract, which was first formulated as "the result of invalid bidding", is analyzed.
The scientific developments devoted to the issues of voidence of transactions and scientific research in the field of public procurement in Ukraine are summarized.
The author's definition of the procurement contract is given: it is an agreement between the Customer and the Participant (more parties), aimed at establishing, transferring or terminating property rights and obligations, which is concluded as a result of the procurement procedure and provides for ownership of property services or works.
The grounds for declaring the procurement contract null and void are listed, namely: concluding a procurement contract before or without the procurement procedure, concluding a procurement contract that differs from the content of the tender offer / offer based on the results of the electronic auction; concluding an agreement during the period of appealing the procurement procedure to the Antimonopoly Committee of Ukraine; concluding a contract in violation of the terms.
The main conceptual differences between a void contract in public procurement and the civil law doctrine of a void transaction are established and characterized. The main difference from void transactions is that the parties and third parties do not have to obtain a court decision to apply the consequences of declaring a transaction invalid, but in cases established by the Civil Code of Ukraine, a void transaction may be recognized by a court as valid.
The notion of "void contract" in public procurement is critically analyzed through the prism of understanding and essential conditions of general civilization of invalid contract, as it is not possible to recognize such a contract valid in court.
The definition of a void contract in public procurement as one that violates public order, is concluded in violation of the procedure provided by law, and makes it impossible to recognize it valid in court.
Topical issues of stimulating the work of civil servants
Authors: Ivanov A. O. 
Published: January 2022

Emphasis is placed on the fact that one of the topical and urgent issues of reforming the system of public administration in Ukraine in general and the institution of civil service in particular is to improve the mechanism of stimulating the work of civil servants. It is noted that the approach chosen by the official authorities to improve the effectiveness of incentives for civil servants is limited mainly to the revision of approaches to their remuneration. At the same time, such important elements of the mechanism of stimulating employment, such as guaranteed career growth, protection from administrative pressure and illegal disciplinary action, guaranteed application of incentives and rational organization of the work process, do not receive due attention and development. It is emphasized that one of the problems of improving the incentives for civil servants is the lack of a clear understanding of the nature and objectives of incentives, its relationship with such phenomena as motivation and encouragement of employees.
Scientific views on the understanding of the essence and content of work incentives, as well as its relationship with such related phenomena as motivation and encouragement are considered. Attention is paid to the conceptual and legislative principles of stimulating the work of civil servants. The problematic aspects of the legislative regulation of stimulating the work of civil servants are identified, as well as the important conditions, the implementation of which is necessary to ensure effective stimulation of the work of civil servants, are outlined. Attention is paid to the role of professional growth and guaranteed career advancement as important elements of stimulating employment. It is emphasized that the requirements of legality and professional ethics cannot be violated for reasons of ensuring high efficiency and effectiveness of civil servants. Particular attention is paid to strengthening legislative guarantees for incentives for civil servants who have made a significant personal contribution to the activities of the state bodies where they work, to reforming and developing the public administration system in general and the civil service in particular.
Self-regulation as a context of critical thinking in cyberpolice officers
Authors: Medvedieva О. V. 
Published: January 2022

The results of a study of self-regulation in the context of critical thinking in cyberpolice are presented. It is theoretically proven that self-regulation is one of the central components of critical thinking, and the interaction of these phenomena enhances the effectiveness of each of them. It is noted that the developed critical thinking and self-regulation acquire special significance in the professional activity of the police.
The following methodological tools were used: test of critical thinking, methods of self-management research, methods of diagnostics of regulation focus. The sample: the first group consisted of 47 cyber police officers, the second - 51 civilian IT specialists. It has been empirically found that cyber police officers are more action-oriented in anticipation of success in difficult situations involving overcoming strong pressure; they are characterized by a better ability to maintain a positive emotional mood and not lose motivation in routine activities, and can better concentrate on the process of activity and ignore external and internal stimuli that interfere with the tasks. Cyberpolice officers show a greater focus on action, hoping for success in dealing with situations of strong external pressure, greater ability to maintain the optimal functioning of all parts of self-regulation in extreme conditions, overcome anxiety and remain focused in stressful situations. These subjects are more successful in integrating contradictions, which allows them to realistically evaluate various contradictory information and perceive contradictory experiences as a sign of real existence, to critically connect it with their own values and meanings. Representatives of this group are more characterized by the focus of prevention in self-regulation, which cyber police consider the best way to achieve the goal, which necessitates awareness, criticality and vigilance in decision-making, systematic evaluation, verification and prevention of errors, which are subjectively significant conditions . Actualization of the focus of prevention in the system of self-regulation of cyberprofessional workers causes a positive emotional coloration of the results of actions in the absence of negative results, and in case of negative consequences becomes a source of negative affective feelings, which initiates vigilance to neutralize probable losses. It is noted that the deployment of further research in the chosen direction will not only enrich the theoretical understanding of the problem, but also provide an opportunity to use the obtained empirical data in the applied psychology of policing.
La innovación educativa y la vinculación con talleres participativos turísticos en la provincia de los Ríos
Authors: Rivera García Christian , Arellano Valencia Darío , Reyes Indio Xiomara Noemi 
Published: January 2022

Introducción. La innovación educativa contempla varias áreas constructivas: tecnología, didáctica, pedagogía, procesos y personas, integradas para transformar el proceso de enseñanza-aprendizaje, manteniendo la novedad de contextos sociales, conservando la memoria milenaria colectiva en la integración e inclusión de los diferentes actores educativos y recreativos en el ámbito nacional donde la Universidad Técnica de Babahoyo mediante su programa de proyectos de vinculación se forja socialmente para conducir y lograr la salvaguarda en la solución de problemas, la toma de decisiones, generando conocimientos sustanciosos en la pertinencia de las carreras universitarias incorpora experiencia en la teoría y práctica sustantiva, multidisciplinar, multiniveles, transformación contextual humana y profesional a través de los talleres participativos colaboran con el aprendizaje virtual sincrónico y asincrónico brindando información actualizada con múltiples beneficios directos para los proyectos de desarrollo comunitario. Objetivo. Innovar en una serie de talleres participativos turísticos gratuitos para apoyar la vinculación de la población hacia nuevas alternativas de empleabilidad local. Metodología. Esta investigación tuvo dos etapas una direccionada hacia la actualización de la línea base de la región conspirando con líneas de investigación institucionales y la segunda etapa incluye el diseño de la recolección de la información aplicando una encuesta digital a los participantes. Conclusiones. Los resultados de la encuesta realizada a 100 personas debelo que las necesidades de reactivación económica post pandemia recae en la seguridad de aplicarse la vacuna bajo todo riesgo nacional e internacional, buscar aliados estratégicos e inversionistas que propicien el financiamiento de nuevos bienes y servicios turísticos.
Enzymatic Oxidation of Ca-Lignosulfonate and Kraft Lignin in Different Lignin-Laccase-Mediator-Systems and MDF Production
Authors: Euring Markus , Ostendorf Kolja , Rühl Martin , Kües Ursula 
Published: January 2022

Laccase-mediator-oxidized lignin offers replacement for conventional chemical binders to produce fiberboards. Compared to the previously reported laccase–mediator system (LMS), a lignin-laccase-mediator-system (LLMS) has an advantage in that it requires much shorter fiber-enzyme incubation time due to significantly increased redox reactions. However, the cost of regularly applying laccase on an industrial scale is currently too high. We have employed CcLcc5 from cultures of the basidiomycete Coprinopsis cinerea as a novel basi-laccase (a CAZy subfamily AA1_1 laccase) in medium-density fiberboard (MDF) production, in comparison to the commercial formulation Novozym 51003 with recombinantly produced asco-laccase MtL (a CAZy subfamily AA1_3 laccase-like multicopper oxidase from the ascomycete Myceliophthora thermophila). With the best-performing natural mediator 2,6-dimethoxyphenol (DMP), unpurified CcLcc5 was almost as good as formulated Novozym 51003 in increasing the molecular weight (MW) of the technical lignins tested, the hydrophilic high-MW Ca-lignosulfonate and the hydrophobic low-MW kraft lignin (Indulin AT). Oxygen consumption rates of the two distantly related, poorly conserved enzymes (31% sequence identity) with different mediators and lignosulfonate were also comparable, but Indulin AT significantly reduced the oxidative activity of Novozym 51003 unlike CcLcc5, regardless of the mediator used, either DMP or guaiacol. Oxygen uptake by both laccases was much faster with both technical lignins with DMP than with guaiacol. In case of lignosulfonate and DMP, 20–30 min of incubation was sufficient for full oxygen consumption, which fits in well in time with the usual binder application steps in industrial MDF production processes. LLMS-bonded MDF was thus produced on a pilot-plant scale with either crude CcLcc5 or Novozym 51003 at reduced enzyme levels of 5 kU/kg absolutely dry wood fiber with lignosulfonate and mediator DMP. Boards produced with CcLcc5 were comparably good as those made with Novozym 51003. Boards reached nearly standard specifications in internal bond strength (IB) and modulus of rupture (MOR), while thickness swelling (TS) was less good based on the hydrophilic character of lignosulfonate. LLMS-bonded MDF with Indulin AT and DMP performed better in TS but showed reduced IB and MOR values.
Single-Center Experience With Endovascular Treatment for Splenic Artery Aneurysms in Long-Term Follow-Up: A Retrospective Study
Authors: Cao Yanyan , Song Songlin , Ouyang Tao , Zheng Chuansheng 
Published: January 2022

ObjectivesTo reveal a single-center experience with endovascular treatment for splenic artery aneurysm (SAA) and analyze the safety and efficacy of the operation in the long-term follow-up.Materials and MethodsA total of 49 patients with SAAs (21 men, 28 women; mean age, 52.4 ± 11.5 years) were enrolled in this study from July 2010 to December 2020. Baseline and characteristics of SAAs were collected. Parent artery coil embolization or combined with sac coil embolization of SAAs, graft-stent implantation, or bare-stent-assisted coil embolization were performed for the treatment of SAAs. Adverse events and follow-up data were recorded.ResultsThe average diameter of SAAs was 3.3 ± 2.5 cm (range, 1.0–13.6 cm). An individual-tailed modality was conducted for three patients. A 100% technical success rate was achieved. No re-intervention procedure was performed in all patients. No major treatment-related adverse events were observed, and no expansion or rupture of SAAs occurred in the average follow-up period of 57.9 ± 27.3 months (19–125 months).ConclusionEndovascular treatment of SAA, including the individual-tailed therapy for three cases, is safe, effective, and minimally invasive with high technical success rates and satisfactory outcomes during the long-term follow-up period.
A Simple and Efficient Method to Cryopreserve Human Ejaculated and Testicular Spermatozoa in −80°C Freezer
Authors: Wang Xiaohan , Lu Fangting , Bai Shun , Wu Limin , Huang Lingli , Zhou Naru , Xu Bo , Wan Yangyang , Jin Rentao , Jiang Xiaohua , Tong Xianhong 
Published: January 2022

Human autologous sperm freezing involves ejaculated sperm, and testicular or epididymal puncture sperm freezing, and autologous sperm freezing is widely used in assisted reproductive technology. In previous studies, researchers have tried to cryopreserve sperm from mammals (rats, dogs, etc.) using a −80°C freezer and have achieved success. It is common to use liquid nitrogen vapor rapid freezing to cryopreserve human autologous sperm. However, the operation of this cooling method is complicated, and the temperature drop is unstable. In this study, we compared the quality of human ejaculation and testicular sperm after liquid nitrogen vapor rapid freezing and −80°C freezing for the first time. By analyzing sperm quality parameters of 93 ejaculated sperm and 10 testicular sperm after liquid nitrogen vapor rapid freezing and −80°C freezing, we found reactive oxygen species (ROS) of sperm of the −80°C freezer was significantly lower than liquid nitrogen vapor rapid freezing. Regression analysis showed that progressive motility, ROS, and DNA fragmentation index (DFI) in post-thaw spermatozoa were correlated with sperm progressive motility, ROS, and DFI before freezing. For the freezing method, the −80°C freezer was positively correlated with the sperm progressive motility. Among the factors of freezing time, long-term freezing was negatively correlated with sperm progressive motility and ROS. Although freezing directly at −80°C freezer had a slower temperature drop than liquid nitrogen vapor rapid freezing over the same period, the curves of the temperature drop were similar, and slight differences in the freezing point were observed. Furthermore, there were no statistically significant differences between the two methods for freezing testicular sperm. The method of direct −80°C freezing could be considered a simplified alternative to vapor freezing for short-term human sperm storage. It could be used for cryopreservation of autologous sperm (especially testicular sperm) by in vitro fertilization centers.Clinical Trial Registration: (website), identifier (ChiCTR2100050190).
The Value of Nasal and Oral Clinical Examination in Febrile Neutropenic Patients for Initiating Antifungal Therapy as a Preemptive Method
Authors: Salehi Mohammadreza , Ghaderkhani Sara , Sharifian Ramezan Ali , Dehghan Manshadi Seyed Ali , Samiee Fard Elahe , Khodavaisy Sadegh , Pourahmad Ramtin , Foroushani Abbas Rahimi , Rodini Kamran , Kamali Sarvestani Hasti 
Published: January 2022

BackgroundInvasive fungal infections (IFIs) are complications that lead to mortality and morbidity in hematologic malignancies. The time of starting antifungal therapy is vital. Preemptive antifungal therapy has appeared recently as a new policy for the management of IFIs based on noninvasive ways in neutropenic patients.MethodsWe enrolled leukemia patients with neutropenia after chemotherapy in Imam Khomeini Hospital Complex, Tehran, Iran. Patients who entered the neutropenic phase were divided into two categories (empirical and preemptive) for receiving antifungal agents. The patients were clinically examined in the preemptive group every day to find IFIs. As soon as clinical evidence of IFIs was observed, antifungal was prescribed. The empirical group patients received antifungals based on the ward protocol. Based on the data in each group, the diagnostic and therapeutic results of cases are followed-up to 3 months. To compare percentages between the two groups, the chi-squared test was used. And to compare two means between the two groups, the independent t-test was used. All the statistical analyses were done in the Statistical Package for the Social Sciences (SPSS) version 24 software (IBM Corporation, Armonk, New York, USA).ResultsWe assessed 132 leukemic patients with inclusion and exclusion criteria. Eventually, 80 patients were enrolled. The mean age was 35.52 years. Demographics data and distribution of leukemia type show no significant differences between the two groups. Despite a higher percentage of IFIs discovered in the preemptive group than the empirical group (25 vs. 18.75%, respectively), but data show no significant differences. The average days of IFIs diagnosis since the beginning of neutropenia in the empirical group were 9.5 days while in the preemptive group, the average days were 5.4 days (p &lt; 0.05). Totally, there were 15 patients with a proven IFI in each group (40% in the empirical group and 60% in the preemptive group). Results significantly show an increase in surgical sinus debridement in the empirical groups (83.3%) vs. the preemptive groups (55.5%), (p &lt; 0.05). The mortality rate differed significantly among the two groups; it was 7.5% in the preemptive group and 25% in the empirical group (p &lt; 0.05).ConclusionDaily oral and nasal cavities examination to find the symptoms of IFIs and then start preemptive antifungal agents may be able to lead to accurate diagnosis, earlier treatment, and decreasing sinus surgery debridement in leukemia patients with neutropenia.