bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-Service Registry Log Builder: A Case Study in National Trauma Registry of Iran
Authors: Yari Eili Mansoureh , Vafadar Safar , Rezaeenour Jalal , Sharif-Alhoseini Mahdi 
Published: July 2022

Abstract
Background Although the process-mining algorithms have evolved in the past decade, the lack of attention to extracting event logs from raw data of databases in an automatic manner is evident. These logs are available in a process-oriented manner in the process-aware information systems. Still, there are areas where their extraction is a challenge to address (e.g., trauma registries).
Objective The registry data are recorded manually and follow an unstructured ad hoc pattern; prone to high noises and errors; consequently, registry logs are classified at a maturity level of one, and extracting process-centric information is not a trivial task therein. The experiences made during the event log building from the trauma registry are the subjects to be studied.
Results The result indicates that the three-phase self-service registry log builder tool can withstand the mentioned issues by filtering and enriching the raw data and making them ready for any level of process-mining analysis. This proposed tool is demonstrated through process discovery in the National Trauma Registry of Iran, and the encountered challenges and limitations are reported.
Conclusion This tool is an interactive visual event log builder for trauma registry data and is freely available for studies involving other registries. In conclusion, future research directions derived from this case study are suggested.
Systemic Immune-Inflammation Index Predicts Outcomes in Platinum-Resistant Relapsed Ovarian Cancer
Authors: Goenka Luxitaa , Thejeswar Nakka , Dubashi Biswajit , Kayal Smita , Ganesan Prasanth 
Published: July 2022

AbstractWe explored the prognostic impact of simple indices that reflect the immunological milieu (neutrophils to lymphocyte ratio [NLR] and systemic immune-inflammation [SII]) in 49 platinum-resistant relapsed ovarian cancer patients. The median progression-free survival (PFS) and overall survival (OS) were 4 and 8 months, respectively. Patients with a lower NLR (≤2.89) had a better PFS (5 vs. 2 months [p = 0.02]) and OS (9 vs. 5 months [p = 0.20]). Factors associated with a worse PFS were NLR > 2.8 (hazard ratio [HR] =2.32, p = 0.02) and SII > 639 (HR =3.70, p = 0.002). SII > 639 independently predicted PFS (HR =4.13, p = 0.03). Future studies should study the validity of inflammatory markers and could consider incorporating it as a biomarker in clinical trials.
Refractory Primary Mediastinal B-Cell Lymphoma: A Case Report of Conventional Chemotherapies, Immune Checkpoint Inhibitors, Polatuzumab Vedotin, Transplantation, and Post-Transplant Large Granular Lymphocytosis
Authors: Pincha Rajat , Radhakrishnan Vivek S. , Kumar Jeevan , Nag Arijit , Bhave Saurabh Jayant , Zameer Lateef , Vinarkar Sushant S. , Das Jayanta , Mishra Deepak Kumar , Chandy Mammen , Nair Reena 
Published: July 2022

AbstractWe report a case of stage IV primary mediastinal B-cell lymphoma in a 27-year-old young woman, who was refractory and chemoresistant to frontline conventional rituximab-based intensive chemotherapy and subsequent lines of conventional and immune checkpoint inhibitor-based therapies. She was successfully treated using a polatuzumab-based regimen and consolidated with an allogeneic haploidentical hematopoietic stem cell transplantation. She developed post-transplant large granular lymphocytosis that was managed conservatively. She is now relapse-free, 600 days post-transplant. The management of this patient provided several teaching points in the use of different modalities of immunotherapies in a hard-to-treat cancer and its related conditions.
Outcomes of Extracorporeal Life Support in Children with Meningococcal Septicemia: A Retrospective Cohort Study
Authors: Henry Brandon Michael , Benscoter Alexis , Perry Tanya , de Oliveira Maria Helena Santos , Misfeldt Andrew , Cooper David S. 
Published: July 2022

AbstractMeningococcal disease is associated with high mortality despite aggressive antibiotic therapy and intensive care support. Patients may develop refractory hypotension and acute respiratory distress syndrome in which extracorporeal membrane oxygenation (ECMO) could serve as a life-saving rescue therapy. However, there is limited data regarding the outcomes of ECMO support in the setting of meningococcal disease. This retrospective analysis of prospectively collected data from Extracorporeal Life Support Organization registry (1989–2019) enrolled children (29 days–18 years old) with Neisseria meningitidis infection receiving ECMO for any support type and mode. A total of 122 patients underwent a single course of ECMO support, equating to 122 ECMO runs. The overall survival-to-discharge rate was 46.7%. Patients receiving pulmonary venovenous (VV) ECMO had the highest survival-to-discharge of 85.7%, while those receiving venoarterial (VA) ECMO for pulmonary indications had a survival of 32.4%. Patients receiving VA ECMO support for cardiac indications had a survival-to-discharge rate of 60.9%. Those needing extracorporeal cardiopulmonary resuscitation (ECPR) had a poor survival (14.3%). Hemorrhagic complications were common, occurring in 43.4% of patients, but not found to be associated with mortality (complication was present in 47.7% of deceased and 38.6% of survivors, p = 0.31). Multivariable logistic regression analysis revealed that neurologic complications were associated with increased odds of mortality (odds ratio: 44.11; 95% confidence interval: 4.95–393.08). ECMO can be utilized as rescue therapy in children with refractory cardiopulmonary failure in setting of meningococcemia. Patients who require pulmonary VV or cardiac ECMO have the best ECMO outcomes. However, the use of ECMO in those suffering cardiac arrest (ECPR) should be undertaken with caution.
Social Thinking Metacognitive Strategies to Support Self-Determined Social Goals in Autistic Youth
Authors: Crooke Pamela J. , Winner Michelle Garcia 
Published: July 2022

AbstractOn any given day, the social mind is taxed with attending to and making sense of a myriad of social events. The social mind is at work when trying to imagine the experiences of others and their inner mental worlds, and is equally active when people seek to approach, connect with, and sometimes avoid one another. Ultimately, the social mind is responsible for thinking about (social) thinking, or social metacognition. Social metacognitive teaching strategies can be helpful for supporting social learners as they observe social landscapes, interpret what is observed to problem solve, or decide whether and how to produce social responses. This article describes how social metacognitive strategies from the Social Thinking Methodology have been used to support the self-determined social goals of two autistic students. Visual frameworks and their underlying theories are provided as evidence-aligned tools for supporting clinical journeys.
Beyond Vital Signs: Pediatric Sepsis Screening that Includes Organ Failure Assessment Detects Patients with Worse Outcomes
Authors: Paulsen Jesseca A. , Wang Karen M. , Masler Isabella M. , Hicks Jessica F. , Green Sherry N. , Loberger Jeremy M. 
Published: July 2022

AbstractPediatric sepsis screening is recommended. The 2005 Goldstein criteria, the basis of our institutional sepsis screening tool (ISST), correlate poorly with clinically diagnosed sepsis. The study objective was to retrospectively evaluate the ISST sensitivity compared with the Pediatric Sequential Organ Failure Assessment (pSOFA). This was a single-center retrospective cohort study. The primary outcome was pSOFA score and ISST sensitivity for severe sepsis. Secondary outcomes included clinical outcome measures. In this severe sepsis cohort (N = 491), pSOFA and ISST sensitivity were 57.6 and 61.1%, respectively. In regression analysis for a positive pSOFA, positive blood culture (odds ratio [OR] 2.2, 95% confidence interval [CI] 1.1–4.3, p = 0.025), older age (OR 1.006, 95% CI 1.003–1.009, p < 0.001), and pulmonary infectious source (OR 3.3, 95% CI 1.6–6.5, p = 0.001) demonstrated independent association. In regression analysis for a positive ISST, older age (OR 1.003, 95% CI 1–1.006, p = 0.031) and intra-abdominal infectious source (OR 0.3, 95% CI 0.1–0.8, p = 0.014) demonstrated independent association. A negative ISST was associated with higher intensive care unit (ICU) admission prevalence (p = 0.01) and fewer ICU-free days (p = 0.018). A positive pSOFA score was associated with higher ICU admission prevalence, vasopressor requirement, and vasopressor days as well as fewer ICU, hospital, and mechanical ventilation-free days (all p < 0.001). Exploratory analysis combining the ISST and pSOFA into a hybrid screen demonstrated superior sensitivity (84.3%) and outcome discrimination. The pSOFA demonstrated noninferior sensitivity to a Goldstein-based institutional sepsis screening model. Further, pSOFA was a better discriminator of poor clinical outcomes. An exploratory hybrid screening model shows superior performance but will require prospective study.
Gas plasma–oxidized sodium chloride acts via hydrogen peroxide in a model of peritoneal carcinomatosis
Authors: Miebach Lea , Freund Eric , Clemen Ramona , Kersting Stephan , Partecke Lars-Ivo , Bekeschus Sander 
Published: July 2022

Gas plasma technology generates reactive oxygen and nitrogen species (ROS/RNS), inducing lethal oxidative damage in tumor cells. The transfer of gas plasma–derived ROS/RNS into liquids has been proposed as an innovative anti-cancer strategy targeting peritoneal carcinomatosis (PC). However, the mechanism of action is under debate. To this end, we compared gas plasma–oxidized medical-grade sodium chloride (oxNaCl) with a concentration-matched control (cmc) of NaCl enriched with equivalent concentrations of H
2
O
2
and NO
3
−
in several cell lines and models of PC. Strikingly, oxNaCl and cmc performed equally well in oxidation and cytotoxic activity in tumor cells in two-dimensional cultures, three-dimensional (3D) tumor spheroids, vascularized 3D tumors grown on chicken-embryo chorioallantoic membranes, and a syngeneic PC mouse model in vivo. Given the importance of immunotherapies in oncology today, we focused on immunological consequences of the treatment. Again, to a similar extent, oxNaCl and cmc increased tumor cell immunogenicity and enhanced uptake by and maturation of peripheral blood monocyte–derived dendritic cells together with an inflammatory secretion profile. Furthermore, NanoString gene expression profiling revealed immune system processes and unfolded protein response-related pathways as being linked to the observed anti-tumor effects for both oxNaCl and cmc. In conclusion, gas plasma–generated oxNaCl and cmc showed equal therapeutic efficacy in our PC-related models. In light of the many promising anti-cancer studies of gas plasma–oxidized liquids and the convenient production of corresponding cmcs in large quantities as needed in clinics, our findings may spur research lines based on low-dose oxidants in peritoneal cancer therapy.
Robotic swimming in curved space via geometric phase
Authors: Li Shengkai , Wang Tianyu , Kojouharov Velin H. , McInerney James , Aydin Enes , Ozkan-Aydin Yasemin , Goldman Daniel I. , Rocklin D. Zeb 
Published: July 2022

Locomotion by shape changes or gas expulsion is assumed to require environmental interaction, due to conservation of momentum. However, as first noted in [J. Wisdom, Science 299, 1865-1869 (2003)] and later in [E. Guéron,
Sci. Am
. 301, 38-45 (2009)] and [J. Avron, O. Kenneth,
New J. Phys
, 8, 68 (2006)], the noncommutativity of translations permits translation without momentum exchange in either gravitationally curved spacetime or the curved surfaces encountered by locomotors in real-world environments. To realize this idea which remained unvalidated in experiments for almost 20 y, we show that a precision robophysical apparatus consisting of motors driven on curved tracks (and thereby confined to a spherical surface without a solid substrate) can self-propel without environmental momentum exchange. It produces shape changes comparable to the environment’s inverse curvatures and generates movement of

10

−
1

cm per gait. While this simple geometric effect predominates over short time, eventually the dissipative (frictional) and conservative forces, ubiquitous in real systems, couple to it to generate an emergent dynamics in which the swimming motion produces a force that is counter-balanced against residual gravitational forces. In this way, the robot both swims forward without momentum and becomes fixed in place with a finite momentum that can be released by ceasing the swimming motion. We envision that our work will be of use in a broad variety of contexts, such as active matter in curved space and robots navigating real-world environments with curved surfaces.
Simulating the behaviour of travelling wave superconducting parametric amplifiers using a commercial circuit simulator
Authors: Sweetnam T , Banys D , Gilles V , McCulloch M A , Piccirillo L 
Published: July 2022

Abstract
Kinetic inductance travelling wave parametric amplifiers (KI-TWPAs) have been simulated using Keysight’s Advanced Design System. A lumped element representation of a superconducting transmission line has been developed using nonlinear inductor elements to represent the current dependency of the intrinsic kinetic inductance. This provides a fast, simple and easily modifiable method for analysing the parametric processes that occur in nonlinear kinetic inductance devices, such as parametric oscillators or amplifiers while also allowing the accompanying RF network to be optimised. This methodology is used to model the behaviour of a select number of KI-TWPA designs operating in the 3-wave mixing (3WM) and 4-wave mixing (4WM) regimes. S-parameters and dispersion properties are extracted from large signal S-parameter simulations, and the gain curve of each amplifier design is generated from harmonic balance simulations. The results are compared to the gain expression from the analytic solutions of the coupled mode equations while making reference to the gain curves of the equivalent KI-TWPAs from literature.
Non-uniform magnetic field as a booster for quantum speed limit: faster quantum information processing
Authors: Aggarwal Srishty , Banerjee Subhashish , Ghosh Arindam , Mukhopadhyay Banibrata 
Published: July 2022

Abstract
We probe the quantum speed limit (QSL) of an electron when it is trapped in a non-uniform magnetic field. We show that the QSL increases to a large value, but within the regime of causality, by choosing a proper variation in magnetic fields. We also probe the dependence of QSL on spin of electron and find that it is higher for spin-down electron in the relativistic regime. This can be useful in achieving faster speed of transmission of quantum information. Further, we use the Bremermann–Bekenstein bound to find a critical magnetic field that bridges the gap between non-relativistic and relativistic treatments and relates to the stability of matter. An analytical framework is developed. We also provide a plausible experimental design to supplement our theory.
Toroidal Alfvén eigenmode stability in JET internal transport barrier afterglow experiments
Authors: Fitzgerald M. , Sharapov S.E. , Siren P. , Tholerus E. , Dreval M. , Szepesi G. , Vallejos P. , Johnson T. , Fil N. , Ferreira J. , Rodrigues P. , Figueiredo A. , Borba D. , Coelho R. , Nabais F. , Mailloux J. , Oliver H.J.C. , Di Troia C. , Napoli F. , Štancar Ž. , Dumont R. , Keeling D. , JET Contributors  
Published: July 2022

Abstract
In this work, we use reduced and perturbative models to examine the stability of toroidal Alfvén eigenmodes (TAEs) during the internal transport barrier (ITB) afterglow in JET experiments designed for the observation of alpha driven TAEs. We demonstrate that in JET-like conditions, it is sufficient to use an incompressible cold plasma model for the TAE to reproduce the experimental adiabatic features such as frequency and position. When ion cyclotron resonant heating (ICRH) is used to destabilize TAEs, the core-localised modes that are predicted to be most strongly driven by minority ICRH fast ions correspond to the modes observed in the DD experiments, and conversely, modes that are predicted to not be driven are not observed. Linear damping rates due to a variety of mechanisms acting during the afterglow are calculated, with important contributions coming from the neutral beam and radiative damping. For DT equivalent extrapolations of discharges without ICRH heating, we find that for the majority of modes, alpha drive is not sufficient to overcome radiative damping.
Delamination Criteria for SiN/TiW Interfaces Tested by Cross-Sectional Nanoidentation and by Four Point Bending
Authors: Lederer M , Walter T , Zareghomsheh M , Khatibi G 
Published: July 2022

Abstract
Interfaces between different material layers are potentially weakest links of microelectronic devices. Therefore, reliable criteria for delamination of structures are required as prerequisite of design optimization. In the present article, delamination of adjacent material layers is studied experimentally and by FEM simulation. An interface between SiN and TiW was delaminated by Cross-Sectional Nanoindentation (CSN) and by Four Point Bending. The adhesion energy observed during CSN is determined by FEM simulation using a method of equivalent loads, which compares CSN with a peel test. In a second approach, delamination during Four Point Bending is simulated by Mixed Finite Elements based on Strain Gradient Elasticity. The Mixed Elements were implemented in ABAQUS with user subroutine UEL. In this approach, the delamination criterion can be defined with use of a critical elastic energy density. The accordance between experiments and theoretical models is demonstrated.
Aluminosilicates: interphase boundary interactions and nature engineering of nanostructures.
Authors: Kotova O , Sun S , Kotova E , Ponariaydov A , Brodskaya R 
Published: July 2022

Abstract
The scientific basis for the development of innovative materials (microporous, nanostructured, composite) based on natural (technogenic and synthetic) aluminosilicate raw materials determine prototypes of new technologies in modern industry. Inspired by this, we studied interphase boundary interactions of the “aluminosicate resource – nanoproduct” type system as a key factor of aggregation and nanostructuring in the processes of mineral formation and synthesis. To study features of the heterogeneity of the structure and their correlations with the thermodynamic parameters of the formation of mineral aggregates and individuals, instrumental and methodological resources were used. Based on previous and current studies of natural, synthesized and technogenic aluminosilicates (zeolites, clays, halloysite, fly ash, halloysite nanotubes, etc., features of the constitution and surfaces, sorption, ion-exchange, catalytic, –QS and +QS, biocompatibility, nontoxicity and other useful properties) the prospects for promotion of their industrial application were considered.
Processing of SnO2/ZnO Heterostructure by the Sol-Gel Technique for Photocatalytic Applications
Authors: Méndez J Paniagua , Uribe E Reyes , García M E Contreras 
Published: July 2022

Abstract
The construction of a SnO2 and ZnO thin film heterostructure is an efficient way to improve the photocatalytic properties of ZnO. However, the current techniques to produce it, for instance, chemical and physical vapor deposition are expensive and therefore not affordable for everyone. Several efforts have been made in order to obtain high quality thin films with lower cost using sol-gel base techniques. The aim of this work is to process high quality and low-cost SnO2 and ZnO thin film heterostructures supported on glass. The thin films were deposited by the spin coating method. The samples obtained were characterized by XRD, SEM, UV-Vis and FTIR. The thin film heterostructure exhibits homogeneous size nanoparticles (10~50 nm) that conform the surface and uniform submicronic thickness. High values of optical transmission >80% were measured for the heterostructure in the range (380-740 nm). The band gap of Eg 3.25 and 3.69 eV were obtained from Tauc’s plot.
Investigation of the optical and antibacterial properties of biosynthesized ZnO nanoparticles using Thuja tincture
Authors: Nagpal K. , Rosario M. S. , Praakle K. , Rauwel E. , Rauwel P. 
Published: July 2022

Abstract
The present study deals with the green synthesis of ZnO nanoparticles using Thuja tincture as a solvent and two different Zn precursors. The crystallinity of the as-synthesized ZnO nanoparticles was investigated by XRD. The biomolecules bonded to the surfaces of the nanoparticles were assessed by Fourier transform infrared spectroscopy. The band gap and defects in these nanoparticles were investigated by UV-Vis and photoluminescence spectroscopies, respectively. The antibacterial properties of these nanoparticles were also investigated against Escherichia coli.
Magnetic structure and UHF conducting properties of composite films (CoFeZr+Al2O3) and (CoNbTa+SiO2)
Authors: Kotov L N , Lasek M P 
Published: July 2022

Abstract
Composite films of A series of compositions [(Co0.45Fe0.45Zr0.10)x + (Al2O3)(1 – x)/5], x = 0.25-0.66 and B series of compositions [(Co0.86Nb0.12Ta0.02)x+(SiO2)(1–x)/3], x=0.14-0.78 were investigated. Images of magnetic micro- and nanostructures of the A, B series composite films were obtained. At small x≤0.3, we observe a chaotic spread of magneto-metallic nanoparticles in a dielectric matrix. In the range 0.30<x<0.55, we observe a mixture of metallic and dielectric microparticles. At large x>0.6, we observe a chaotic scattering of dielectric nanoparticles in a magneto-metallic matrix. We obtained dependences of the specific impedance modulus of composite metal-dielectric films on the current frequency and on the concentration of the metal alloy of A, B series films. The analysis of the spectra showed that films in the frequency range from 0.1 to 3 GHz could exhibit three behaviors of the impedance spectra. For films with x up to the percolation threshold, a capacitive character is observed. The impedance in the field of percolation processes is capacitive, inductive or mixed character. After the percolation threshold, the impedance has an inductive character, and the frequency-dependent character of the magnetic permeability of the films can make a large contribution to the behavior of the spectra.
Arc welding safety zones determination as a function of the UV radiation
Authors: Kafi Abdallah , Nyikes Zoltán , Schramkó Márton , Kovács Tünde Anna 
Published: July 2022

Abstract
Welding technology is a useful and common technology of the industry. Even though this process establishes unhealthy effects (smoke, heat, UV, or infrared radiation, etc.). About the welders’ healthy and the environmental safety requirements the dangerous radiation area determination is very important. In this research, the authors use the literature data of the gas metal arc welding established UV radiation intensity like the effect of the different welding parameters and the effect of the distance from the UV source. The goal of the authors is to determine different safety level zones around the welder or welder robot as a function of the UV radiation intensity.