bluuebunny/crossref_metadata_2025_split huggingface dataset:
C17: Syndrome de Demons-Meigs simulant un cancer de l’ovaire : A propos d’un cas clinique à l’Hôpital Régional de Fatick
Authors: Mihimit A , Touré A I , Keita A , Bah M , Pereira E R , Oumar O A , Diamé I D , Diaby M S , Traoré B , Ka Sidy , Dem Ahmadou 
Published: June 2022

INTRODUCTION : Le syndrome de Demons-Meigs associe une tumeur bénigne de l’ovaire et d’un épanchement thoracique et abdominal, il s’agit d’une pathologie rare dont le mécanisme physiopathologique n’est pas encore bien élucidé et fait souvent craindre souvent une néoplasie ovarienne du fait de l’existence de l’ascite et de l’élévation importante du CA-125. Nous rapportons dans cette observation le cas d’un syndrome de Demons-Meigs chez une jeune femme de 36 ans. OBSERVATION : Il s’agit de Mme MCN, quatre gestes, quatre pares, reçue pour douleur abdomino-pelvienne, une masse abdominale, à l’examen clinique, elle présentait un syndrome d’épanchement pleural et péritonéale avec une masse ovarienne et un taux de CA-125=406,6 UI/ml. L’échographie et le scanner abdominopelvien révélaient une masse ovarienne mixte à prédominance tissulaire avec une ascite de grande abondance. Une Laparotomie réalisée révélait une ascite de grande abondance, l’utérus et les trompes étaient sains, aucune lésion péritonéale suspecte, ovaire gauche est sain, une masse ovarienne droite de 300x150 mm. Une annexectomie droite a été réalisée. Les suites opératoires ont été simples avec assèchement des épanchements. La CA-125 de contrôle est revenue normale après six mois de suivi. Les résultats d’anatomie pathologique révèlent un fibrothécome. CONCLUSION : Bien que rare, le syndrome de Demons-Meigs doit être connu des chirurgiens car il peut simuler une néoplasie ovarienne évoluée. L’existence d’une ascite et/ou d’un épanchement pleural n’est pas forcément synonyme de malignité en présence d’une tumeur ovarienne. La reconnaissance préopératoire de ce syndrome est possible. Elle permet d’éviter la réalisation des gestes chirurgicaux lourds dans le traitement du cancer de l’ovaire et inutiles dans cette pathologie bénigne qui a un bon pronostic.
C20: One week breast radiotherapy: Evaluation dosimétrique et clinique de l’implémentation de la rIMRT (radiothérapie conformationelle par modulation d’intensité restreinte)
Authors: Ka K , Yessoufou M I , Dieng D , Louvel G , Riveira S 
Published: June 2022

INTRODUCTION : Plusieurs essais ont permis de conforter la place de l’hypo-fractionnement dans le traitement adjuvant des cancers du sein. Plus récemment, l’essai FAST FORWARD qu’on peut traiter en une semaine et avoir les mêmes résultats à cinq ans. Nous avons mis en place un protocole de traitement adjuvant des cancers du sein en une semaine dans ce contexte de Covid-19. MATERIELS ET METHODES : Toutes les patientes sont vues en consultation et traitées pour la première fraction le lundi. La technique d’inspiration bloquée est systématiquement proposée. La consultation de fin de traitement est effectuée le vendredi (après cinq séances). RESULTATS : Du 8 Février 2021 au 31 Mai 2021, 24 patientes ont été traitées en rIMRT sur une semaine selon le schéma FAST FORWARD dans le programme « one week breast radiotherapy ». L’âge médian des patientes était de 71 ans. Le carcinome canalaire infiltrant était le type histologique le plus représenté (79,1%). Les récepteurs hormonaux étaient positifs chez 19/24 patientes et le Her2 chez une/24. Le grade tumoral 2 était de 62,5% et les emboles vasculaires négatifs. La tumorectomie était faite chez 23 patientes (95,83%). Le sein gauche représentait la localisation préférentielle. La comparaison dosimétrique 3D et rIMRT montrait une meilleure couverture sur les organes à risque en faveur de la modulation d’intensité. CONCLUSION : La RCMI permet d’avoir une homogénéité des doses et ainsi de faciliter la radiothérapie en une semaine selon le FAST FORWARD. Nous avons débuté ce type de traitement dans notre centre pour des patientes sélectionnées.
Peningkatan Daya Saing UKM Minuman Rumah Herbal Mak Nyak di Kabupaten Jember
Authors: Wijayanti Fefi Nurdiana , Setyowati Trias 
Published: June 2022

Jamu termasuk minuman herbal yang menjadi warisan budaya bangsa Indonesia. Usaha jamu tradisional mayoritas dilakukan oleh UKM atau kelompok usaha rumahan, seperti usaha jamu tradisional yang dilakukan oleh kelompok anggota Dama Aster Dahlia. Implementasi kegiatan Dama melalui usaha pembuatan jamu dari rempah ini menjadi upaya peningkatan ekonomi keluarga, pendampingan yang dilakukan secara periodik dan peningkatkan pengetahuan serta keterampilan anggota Dama Aster Dahlia. Peningkatkan produksi dan penjualan akan meningkatkan penghasilan anggota Dama, proses pemberdayaan perempuan akan tampak dari berubahnya wawasan dan sikap kerja mereka. Pelaksanaan PkM dalam bentuk ceramah, diskusi dan tanya jawab, praktek dan supervisi, monitoring dan evaluasi. Mitra Dama Aster Dahlia sebagai peserta sosialisasi, juga bertindak sebagai peserta pelatihan dan pendampingan pengurusan NIB dan Sertifikat Halal.
Obtenção de Xilooligossacarideos por resíduos lignocelulósicos: alternativa para produção de compostos funcionais para alimentos
Authors: Barreto Andressa Ribas , Zancan Luiza Rodrigues , Menezes Cristiano Ragagnin de 
Published: June 2022

A crescente demanda por novos alimentos que sejam capazes de promover a saúde e prevenir doenças, tem atraído a atenção mundial sobre os prebióticos. Xilo-oligossacarídeos (XOS) são considerados uns dos poucos nutracêuticos que podem ser produzidos a partir da biomassa lignocelulósica. Esta biomassa, por sua vez, é considerado um resíduo de baixo custo e que muitas vezes representa um problema sistêmico para o meio ambiente. Com isso, a produção de XOS a partir de resíduos agrícolas oferece grandes possibilidades para a indústria alimentícia como matéria-prima barata e disponível em abundância. As principais vantagens do consumo de XOS, provém da estimulação do crescimento seletivo da microflora intestinal benéfica, incluem a redução dos índices glicêmicos e de colesterol no sangue, de reduzir enzimas pró-carcinogênicas no trato gastrointestinal, melhorar a absorção de minerais no intestino grosso, além de estimular o sistema imune. Com isso, o objetivo deste artigo é demonstrar os efeitos funcionais dos XOS e a sua obtenção à partir da biomassa lignocelulósica, como alternativa para a formulação de alimentos saudáveis além de propiciar uma alternativa viável para a diminuição dos resíduos agrícolas dispostos no meio ambiente.
Assessment of the Latrine Facilities and the Health Condition in IDP Camps in Borno State
Authors: Asabe H. Mshelbara , Mahya Stanley , Emmanuel I. Nkeleme , Ribah Muhammad Marafa , Fatai Adeyemo Adebisi 
Published: June 2022

There are over 2.1 million Internal Displaced Persons (IDPs) who have been in camps and host communities due to the conflict between the Nigerian state armed group and non-state armed group. The provision of aides to reduce the suffering of these people, especially women and children have brought questions in terms of the adequacy and functionality of the latrine facilities in the IDP camps. This paper assesses the latrine facilities and their corresponding health implication in the selected official IDP camps in Borno State Nigeria. A well-structured questionnaire was employed and administered to various categories of the respondents in twelve(12) out of the sixteen (16) officials camps within the area of study to determine their perception of the latrine and the health impact was assessed. A total of 331questionnnaires were received well filled out of the 392 distributed giving a percentage response of 84.4%, and the data collected was analysed using SPSS version 19.0. the result revealed among others that: the major type of latrine in the camps is the ‘traditional pit latrine’. According to a larger percentage of the respondents, there are less than forty (40) latrines in the Camps. Also, it was discovered that the latrine is usually de-sludge but is done once in two months. This is against the standard requirement from the UNHCR and SPHERE standards. also, the most common illness experienced in the camp arranged in the order of severity is; ‘Diarrhea’ STDs; Fever, and Tuberculosis. Consequently, it is recommended that there should be strict compliance concerning the construction of latrines and toilet facilities. They should be constructed by the provision of standards like UNHCR and sphere, as this will help in reducing the tendency to spread diseases in the camp.
Analysis of Sustainable Teacher Professionality Development through Scientific Publications in High School
Authors: Wahyuni Yusri , Muji Anggarda Paramita , Nurlaili . , Rusdinal . , Gistituati Nurhizrah 
Published: June 2022

Aims: Describe how to implement sustainable professional development through scientific publications in high school.
Study Design: Qualitative and descriptive approach.
Place and Duration of Study: Sample: High school teachers in the city of Padang, between Mei 2022.
Methodology: This study uses a qualitative and descriptive approach. The subjects in this study were high school teachers in the city of Padang, totaling 23 people. Research data in the form of qualitative data were collected through questionnaires. The data were analyzed using descriptive statistics to describe the state of the data by presenting responses to a Likert scale questionnaire. The data presented provides an understanding of the phenomena that occur, then the researcher plans further actions based on the significance of the phenomenon.
Results: This research focuses on five indicators designed to determine how the implementation of sustainable professional development for teachers in senior high schools is carried out. The five indicators are activeness in professional activities, professional development planning, making scientific works, product development to support the learning process and activeness in scientific activities.
Conclusion: The five indicators are activeness in professional activities, professional development planning, making scientific works, product development to support the learning process and activeness in scientific activities.
Serological Pattern of Hepatitis B Virus Infection and Risk Factors among Infected Individuals in Port Harcourt, Rivers State, Nigeria
Authors: Koate Baribefe Banavule Daniel , Adias Teddy Charles , Bartimaeus Ebirien-Agana Samuel , Jeremiah Zacchaeus Awortu 
Published: June 2022

Hepatitis B virus infection is a serious global public health challenge that affects more than two billion people worldwide. This study aimed to evaluate the serological pattern of HBV infection in HBV infected patients in Port Harcourt, Nigeria. The main aim of this study was to evaluate the serological pattern of hepatitis B infection in Port Harcourt, Nigeria. This was a comparative cross sectional study carried out on 260 hepatitis B patients and blood donors attending hepatitis B clinics, and blood banks in Rivers State University Teaching Hospital, Port Harcourt, Military Hospital, Port Harcourt, and University of Port Harcourt Teaching Hospital, Choba. The study involved the use of hepatitis B panel assay, measurement of prevalence of hepatitis B virus infection in Port Harcourt, assessment of hepatitis B serological markers in all subjects, determination of the presence and prevalence of occult HBV among participants. HBV 5-parameter (panel) Rapid Test kit was used to assess HBV serological markers. Standard operation procedure, good laboratory practice, External/Internal Quality Control were used accordingly and Quality Assurance ensued. 84.2% participants were males, 15.8% females aged between 19 and 65 years, Mean ±SD age 30.57±9.70 years, Participants from 20 states, South-South, South-East, and other Geo-political Zones of Nigeria, resident in the cosmopolitan city of Port Harcourt were enrolled. Result obtained showed serological markers among test subjects as 77.3% HBsAg, 43.97% HBsAb, 48.94% HBcAg, 36.17% HBcAb, and 46.81% HBeAg. Grouping of HBV panel assay result was HBV positive 1 (Occult HBV) 7.8% (n=11), HBV positive 2 73.76% (n=104), HBV positive 3 – (occult HBV post treatment) 14.18% (n=20), HBV positive 4 4.26% (n=6). All five serological markers of HBV in infected patients in PHC are evident in significant proportions indicating real infections at different stages of disease manifestation. Mass screening for HBV infection is recommended for our populace to check spread.
Bio-efficacy of Herbicides with Different Water Volumes and Spray Timing under Zero Tillage Rice Residue Retention Scenario against Phalaris minor in Wheat
Authors: Chaudhary Ankur , Yadav Dharam Bir , Singh Samunder , Poonia Todar Mal , Punia Satbir Singh , Singh Narender 
Published: June 2022

Background: Continuous use of the similar modes of action-based herbicides leads to the development of herbicide resistance in wheat-associated weeds in north-west India. Accelerated development of multiple resistance against most of the available post-emergence herbicides emphasize the use of pre-emergence herbicides. But, the efficacy of pre-emergence herbicide is a matter of concern as surface retained stubbles and/or straw alter herbicide efficacy associated with a direct interception of herbicide.
Methods: A field study was conducted for two rabi seasons (2018-19 and 2019-20) to optimize spray volume and time of application for improving the bio-efficacy of pre-emergence herbicides under zero tillage full rice residue scenario. The herbicidal treatments (g/ha) included pendimethalin + pyroxasulfone (1000.0+127.5) as pre-emergence (PE), pyroxasulfone (127.5) as PE, pyroxasulfone (127.5) as early post emergence (EPoE), aclonifen+diflufenican (1002+200) EPoE, halauxifen methyl+ fluroxypyr (7.3+233.4) as EPoE, flumioxazin (100) as PE with two different water volumes 500 and 1000 liter/ha along with pendimethalin fb pinoxaden (1500+50) in 500 l/ha water volume, pendimethalin (1500) as PE in 375 l/ha water volume, weed free and weedy check.
Results: The present study showed that pendimethalin + pyroxasulfone as PE with a higher spray volume of 1000 l/ha and alone application of pyroxasulfone as EPoE produced similar Phalaris minor control as with pendimethalin fb pinoxaden (PE fb Post) under full rice residue scenario in zero-till wheat.
MRI Supplemented with Diffusion Weighted Image in Characterization of Soft Tissue Masses of the Wrist and Hand
Authors: Elsharkawy Asmaa Yehya Abdallah , Elsadany Hanan Mohammed Omara , Younes Rasha Lotfy , Hassanien Omar Ahmed 
Published: June 2022

Background: The wrist joint is considered to be a condyloid synovial joint of the distal upper limb that connects and serves as a transition point between the forearm and hand. Hand and wrist soft tissue masses comprise a special subset of soft tissue masses. MRI imaging has an important role in characterization of soft tissue tumors, yet, it lacks specificity for differentiation between benign and malignant lesions.Diffusion-weighted imaging (DWI) is a non-invasive method for investigation of tumor histological content and used for differentiation between benign and malignant masses.
Aims: This study aimed at assessment of the role of MR diffusion Weighted imaging (DWI) in the evaluation of soft tissue masses of the wrist and hand.
Patients and Methods: This study conducted on 30 patients with soft tissue masses of the wrist and hand. They were referred from Orthopedic and Physiotherapy Departments to MRI unit in Radio-diagnosis Department, Tanta University Hospital. The study was conducted from November 2018 to November 2019. MRI with DWI was conducted for each one of them and results were correlated with histopathological examination.
Results: There is a significant difference in the mean ADC value between benign and malignant soft tissue tumors. Increased apparent diffusion coefficient (ADC) values represent an increase in extracellular water or loss of cell membrane integrity whereas decreased ADC values reflect decrease in extracellular water content or increase in cell number or size.
Conclusions: this study proved the role of MRI and supplementary Diffusion weighted image (DWI) with numerical ADC values in characterization of soft tissue masses of the wrist and hand.
Effect of Surface Treatments on Bond Strength of Resin Cements to Titanium: A Literature Review
Authors: Alzahrani Reem Ahmed , Wali Ammar Turki , Alamri Shaima Fahad , Bedaiwi Ibraheem Talal , Alrehaili Fetoon Marzoog 
Published: June 2022

Objectives: The aims of this literature review are to provide answers to questions on how to improve bonding between titanium and resin cement and how to further implement, in clinical practice, titanium-resin as an alternative to conventional metal–resin systems.
Material and Methods: A literature search of PubMed was conducted and eight fulfilled the search criteria, namely mentions of titanium, resin cement, bond strength, surface treatments, and luting agents. These papers were compiled for comparison and evaluated regarding the bond strength achieved with different methods.
Results: The results strongly indicate that there are possibilities to improve the adhesion methods for titanium–luting agents.
Conclusions: The combination of micromechanical and chemical surface treatments enhanced the adhesion between different resin cements and titanium. It is important to select the appropriate surface treatments of titanium regarding the type of resin cement that will be used. Utilizing titanium with resin cements for crowns and fixed partial dentures can be recommended for routine clinical use.
Transient Lymph Node Immune Activation by Hydrolysable Polycarbonate Nanogels
Authors: Czysch Christian , Medina‐Montano Carolina , Zhong Zifu , Fuchs Alexander , Stickdorn Judith , Winterwerber Pia , Schmitt Sascha , Deswarte Kim , Raabe Marco , Scherger Maximilian , Combes Francis , De Vrieze Jana , Kasmi Sabah , Sandners Niek N. , Lienenklaus Stefan , Koynov Kaloian , Räder Hans‐Joachim , Lambrecht Bart N. , David Sunil A. , Bros Matthias , Schild Hansjörg , Grabbe Stephan , De Geest Bruno G. , Nuhn Lutz 
Published: June 2022

AbstractThe development of controlled biodegradable materials is of fundamental importance in immunodrug delivery to spatiotemporally controlled immune stimulation but avoid systemic inflammatory side effects. Based on this, polycarbonate nanogels are developed as degradable micellar carriers for transient immunoactivation of lymph nodes. An imidazoquinoline‐type TLR7/8 agonist is covalently conjugated via reactive ester chemistry to these nanocarriers. The nanogels not only provide access to complete disintegration by the hydrolysable polymer backbone, but also demonstrate a gradual disintegration within several days at physiological conditions (PBS, pH 6.4–7.4, 37 °C). These intrinsic properties limit the lifetime of the carriers but their payload can still be successfully leveraged for immunological studies in vitro on primary immune cells as well as in vivo. For the latter, a spatiotemporal control of immune cell activation in the draining lymph node is found after subcutaneous injection. Overall, these features render polycarbonate nanogels a promising delivery system for transient activation of the immune system in lymph nodes and may consequently become very attractive for further development toward vaccination or cancer immunotherapy. Due to the intrinsic biodegradability combined with the high chemical control during the manufacturing process, these polycarbonate‐based nanogels may also be of great importance for clinical translation.
Digital Light Processing 3D Printing of Tough Supramolecular Hydrogels with Sophisticated Architectures as Impact‐Absorption Elements
Authors: Dong Min , Han Ying , Hao Xing Peng , Yu Hai Chao , Yin Jun , Du Miao , Zheng Qiang , Wu Zi Liang 
Published: June 2022

AbstractProcessing tough hydrogels into sophisticated architectures is crucial for their applications as structural elements. However, Digital Light Processing (DLP) printing of tough hydrogels is challenging because of the low‐speed gelation and toughening process. Described here is a simple yet versatile system suitable for DLP printing to form tough hydrogel architectures. The aqueous precursor consists of commercial photoinitiator, acrylic acid, and zirconium ion (Zr4+), readily forming tough metallo‐supramolecular hydrogel under digital light because of in situ formation of carboxyl–Zr4+ coordination complexes. The high‐stiffness and antiswelling properties of as‐printed gel enable high‐efficiency printing to form high‐fidelity constructs. Furthermore, swelling‐induced morphing of the gel is also achieved by encoding structure gradients during the printing with grayscale digital light. Mechanical properties of the printed hydrogels are further improved after incubation in water due to the variation of local pH and rearrangement of coordination complex. The swelling‐enhanced stiffness affords the printed hydrogel with shape fixation ability after manual deformations, and thereby provides an additional avenue to form more complex configurations. These printed hydrogels are used to devise an impact‐absorption element or a high‐sensitivity pressure sensor as proof‐of‐concept examples. This work should merit engineering of other tough gels and extend their scope of applications in diverse fields.
Targeting Bone Tumor and Subcellular Endoplasmic Reticulum via Near Infrared II Fluorescent Polymer for Photodynamic‐Immunotherapy to Break the Step‐Reduction Delivery Dilemma
Authors: Zhang Xianghong , Wan Jia , Mo Fuhao , Tang Dongsheng , Xiao Haihua , Li Zhihong , Jia Jinpeng , Liu Tang 
Published: June 2022

AbstractSpecific localization of photosensitizers (PSs) to a certain organelle could result in targeted attack to cause greater trauma to cancer cells, eventually maximizing photodynamic therapy (PDT). However, currently, efficient and precise transportation of PSs via drug delivery to tumor cells and subcellular organelles is still challenging, due to a so‐called step‐reduction delivery dilemma (SRDD) which also threatens anticancer drug delivery to exert their efficacy. Herein, a cascade targeting near infrared II (NIR II) fluorescent nanoparticles (NPER/BO‐PDT) is designed that can target bone tumor first and then target the subcellular organelle of endoplasmic reticulum (ER). It is found that NPER/BO‐PDT achieves the targeted accumulation of the bone tumor and then ER. NPER/BO‐PDT generates reactive oxygen species (ROS) in the subcellular organelles of ER under near infrared light irradiation. The continuous ER stress by ROS promotes the release of more damage‐associated molecular patterns, induces immunogenic cell death, stimulates the adaptive immune response, and further synergistically inhibits tumor growth, achieving the so‐called photodynamic‐immunotherapy. Overall, this study exemplifies a safe and efficient nano‐drug delivery system for a bone and ER cascade targeting via delivery of PSs to break the SRDD and highlights potential clinical translation.