bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthetic Analogue of Leu-Enkephalin in COVID-19 (a Prospective Clinical Study)
Authors: Magomedov M. A. , Burda  N. G. , Misikov Z. F. , Ryzhkov A. Yu. , Antonova V. V. , Cherpakov R. A. 
Published: August 2022

One of the main problems facing intensivists when treating patients with COVID-19 is severe and critical acute respiratory distress syndrome (ARDS) with the underlying viral pneumonia. The current guidelines of the Russian Ministry of Health (Version 15 of 22.02.22) do not include drugs with a lung protective effect. This issue could be solved by administration of a synthetic analogue of leu-enkephalin.Aim. Study the eﬃcacy of a synthetic analogue of leu-enkephalin in ARDS in patients with COVID-19.Materials and methods. The study included 35 patients divided into 2 groups. Group 1 (main) patients (n=15) in addition to standard therapy received a continuous infusion of synthetic analogue of leu-enkephalin at a rate of 5 µg/kg/hour for 5 days. Patients from group 2 (control, n=20) were treated according to the Temporary Guidelines of the Ministry of Health (V.15), but without the synthetic analogue of leu-enkephalin. The radiological data, frequency, severity and evolution of respiratory complications, changes in P/F (PaO2/FiO2) ratio, as well as changes in the scores of prognostic APACHE II, SOFA, and NEWS scales were evaluated.Results. In patients taking the studied drug, the percentage of lung damage did not change with the median (IQR) of 0 [–8; 0], while in the control group it increased by approximately 10% with the median (IQR) of +10,0 [+2; +20] (P=0.001). The proportion of patients in group 1 with positive disease evolution within 5–9 days after treatment initiation was significantly higher and reached 46.7 [24.8; 69.9]%, whereas in group 2 it was 15.0 [5.2; 36.0]% (P=0.04). Also, in group 1, starting from day 4, the median P/F ratio was significantly higher than in group 2 reaching 220 [185;245] versus 127 [111;158], respectively (P=0.014). The need for non-invasive lung ventilation in group 1 on day 7 averaged 7%, while in group 2 it was as high as 45.0%, which was significantly higher than in the main group (P=0.013).Conclusions. The use of synthetic analogue of leu-enkephalin according to the specified regimen had a significant impact on the main parameters of the viral pneumonia severity. The results serve as a rationale for the development of a novel effective treatment strategy to supplement the current standard COVID-19 management.
Efecto de la fertilización sobre el rendimiento de rizoma y almidón de achira (Canna edulis, Ker) en Nariño, Colombia
Authors: Volveras-Mambuscay Belisario , López-Redón Juan Fernando , Rodríguez-Borray Gonzalo 
Published: August 2022

Introducción. En Colombia la producción de almidón de achira (Canna edulis, Ker) es importante en la zona andina, en los departamentos de Nariño, Huila y Cundinamarca. Objetivo. Evaluar el efecto de la densidad de siembra y fertilización en el rendimiento de almidón y rizoma de achira y la relación entre ambos, en el departamento de Nariño, Colombia. Materiales y métodos. Entre septiembre de 2016 y octubre de 2017 se instalaron ensayos en dos localidades del municipio La Cruz Nariño, Colombia. Con diseño de BCA fue distribuido en parcelas sub-sub-divididas con los siguientes tratamientos: los bloques estuvieron compuestos de dos parcelas principales correspondientes a dos cultivares regionales de achira, las subparcelas correspondieron a dos densidades de siembra 10 000 y 12 500 plantas/ha y las sub-sub-parcelas correspondieron a tres niveles de N, P2O5 y K2O con fuente química y abono orgánico. Resultados. El rendimiento de rizoma fue superior al promedio nacional con todos los tratamientos; el mejor rendimiento se obtuvo en el nivel más alto de fertilización química. Hubo mejor respuesta del cultivar morado con 6,15 t ha-1 de almidón, 15 % más que el cultivar verde y un rendimiento almidón/rizoma 21 % superior. Con la mayor densidad de siembra se obtuvo un 15 % más de almidón y con abono orgánico el rendimiento de almidón fue superior al promedio regional, pero 50 % inferior a la fertilización química, con la cual se obtuvo en promedio 6,23 t ha-1. Conclusión. Hubo respuesta de la achira a la aplicación de N-P-K y a la densidad de siembra sobre rendimiento de almidón y rizoma de achira y la relación entre ambos, además se encontró una diferente respuesta agronómica de los cultivares bajo las condiciones de estudio.
Software ELAO para Aprender Inglés
Authors: Tello Fons Isabel , Valero Doménech Esperanza 
Published: August 2022

El uso extenso y diario de las computadoras y de la red de redes ha contribuido a acrecentar el interés por las herramientas informáticas para la enseñanza y el aprendizaje del inglés. Hoy en día es innegable el papel destacado que juegan los programas de software de enseñanza de idiomas, pues estos modifican el escenario en el que profesores y estudiantes se han movido hasta ahora y hace importante cuestionarse la calidad de los mismos.
Este trabajo pretende analizar y comparar cinco programas de software de aprendizaje del inglés comercializados actualmente con el objetivo de valorar su funcionamiento, materiales, principales atributos, facilidad a la hora de usarlos y características de presentación y organización. Para llevar a cabo esta tarea se proponen una serie de categorías de análisis que se seguirán para valorar cada producto de software. Los resultados de este estudio nos permitirán avanzar en los criterios de evaluación de este tipo de software con vistas a cumplir con las expectativas y necesidades de los estudiantes y a proponer mejoras que los proveedores de estos productos puedan tener en cuenta.
Transitioning from face-to-face classes to emergency remote learning
Authors: Vargas Barquero Vivian , Gúzman Arce Natin , León Susana Murillo 
Published: August 2022

Abstract
The COVID-19 pandemic forced higher education institutions to pivot their traditional face-to-face teaching to emergency remote teaching (ERT), causing a shift in delivery modalities. Recent studies have described ERT's existing experiences as an emerging transitioning methodological alternative to comply with the social distancing and safety guidelines stipulated globally. This research study merges data from two sources in a convergent parallel mixed method design. Thus, the study presents a systematization of the action plan undergone by the faculty authorities of Universidad Nacional of Costa Rica and a follow-up trace analysis of newcomer's experiences in the Bachelor major in English Teaching as a Foreign Language at the school of Literature and Language Sciences (ELCL, Spanish initials) during the first term of 2020. Results evince the students' experience in tech possibilities, electronic device ownership, and healthy, economic, social, or physical learning setting issues. Lastly, the researchers propose an empathetic design thinking further research study to determine where to integrate technology at the BA TEFL major.

Keywords: COVID-19 pandemic, face-to-face teaching, emergency remote teaching, newcomer students' experiences, higher education
Validated UPLC-MS/MS method for the determination of ivosidenib in rat plasma: Application to a pharmacokinetic study
Authors: Chen Minle , Xu Jia , Chen Feifei , Zhou Quan , Wang Shuanghu , Han Aixia 
Published: August 2022

AbstractIvosidenib (AG-120) is an unlisted, but estimated to be valid, oral inhibitor for isocitrate dehydrogenase 1 (IDH1) in the phase Ⅰ study of IDH1-mutated acute myeloid leukemia (AML) patients. This paper presents the investigation and validation of a rapid, effective, qualitative and quantitative determination method of ivosidenib in rat plasma by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). The samples were treated using acetonitrile precipitation to remove protein influence. Then, the supernatant was extracted to analyze plasma concentration traits. In the UPLC system, acetonitrile and water containing 0.1% formic acid were selected as a cosolvent mobile phase, applying a gradient elution to isolate compounds in a C18 column. Mass detections were performed on a triple quadruple mass spectrometer in positive ion mode. Electroshock characteristic fragment ionization was used for m/z 583.95→214.53 for ivosidenib for quantitative determination, m/z 583.95→186.6 for qualitative determination, and m/z 492.06→354.55 for IS. The selectivity, linearity, stability, accuracy and precision were verified by reaching the guideline criteria from European Medicine Agency (EMA) and the Food and Drug Administration (FDA). The calibration curve was linear over the concentration range of 2–2,000 ng mL−1 for ivosidenib in rat plasma with a lower limit of quantification (LLOQ) of at least 2 ng mL−1. Additionally, there was no distinct matrix effect or carry-over phenomenon. The method was successfully established and applied to separate ivosidenib from plasma, with the entire analytical process being performed within 3 min for each sample, which shows high-efficiency and convenience for further studies of ivosidenib.
Primary drug non-adherence in dermatology patients: prevalence, pattern and reasons
Authors: Anaba Ehiaghe L. , Arabambi Babawale 
Published: August 2022

<p class="abstract"><strong>Background:</strong> Primary drug non-adherence, a pervasive problem in dermatology is not readily documented despite the adverse effect of this phenomenon on the management of patients. The aim of the study was to document the prevalence, pattern and reasons for primary drug non-adherence in dermatology patients.</p><p class="abstract"><strong>Methods:</strong> This prospective cross-sectional questionnaire based study was conducted from June to December 2021 amongst 302 consecutive consenting adult patients returning to the dermatology clinic following an initial diagnosis and a prescription for medications. Data collected included socio-demographic parameters, primary drug adherence, and number of drugs prescribed, number not purchased, and reason for non-adherence. Data analysis was done in R Studio [R Core Team (2021)].<strong></strong></p><p class="abstract"><strong>Results:</strong> Three hundred and two (302) patients aged 13 to 87 years with a mean age of 41.72±18.8 years were recruited into the study. Prevalence of primary non-drug adherence was 26.2% (79/302). Amongst the non-adherent patients; 73.4% were females and 26.6% were males. The reasons for non-drug adherence ranged from non-availability of drug (63.3%) to patient forgetting about the prescription. (1.3%). Route of drug not adhered to was Topical in 72%, Oral in 22.7%, oral and topical in 5.3.</p><p class="abstract"><strong>Conclusions:</strong> Primary drug non-adherence is common with dermatology patients. The propensity for primary non-drug adherence is increased when the number of drugs prescribed are more than three. Dermatologists need to consider the use of drugs capable of addressing multiple symptoms and thereby reduce the number of drugs prescribed. </p><p class="abstract"> </p>
Progressive pigmented purpuric dermatosis in skin of color: a dermoscopic and histopathological correlation
Authors: Ankad Balachandra S. , Rajagopal Tanuja , Raghuveer Chekuri , Mallapur Anirudh A. , Nikam Balkrishna P. , Rangappa Manjula 
Published: August 2022

<p class="abstract"><strong>Background:</strong> Progressive pigmented purpuric dermatosis (PPPD) is a chronic cutaneous presents with petechiae, purpura on hyperpigmented yellowish-brown macules or patches. Diagnosis is straight forward, sometimes may be challenging for the diagnosis. Dermoscopy is a non-invasive tool. It gives characteristic patterns in PPPD. However, dermoscopic descriptions in skin of color are limited to case reports. Here, dermoscopic evaluation in skin of color is studied in detail. </p><p class="abstract"><strong>Methods:</strong> It was a cross sectional observation study. Ethical clearance and written consent was obtained. Patients of skin type 4 and 5, attending dermatology clinic with suspected lesions of PPPD were selected serially. Handheld dermoscope was used for examination. Site for dermoscopic examination was considered as target area. Skin biopsy was taken. Dermoscopic patterns were analysed and features were correlated with histopathological changes.<strong></strong></p><p class="abstract"><strong>Results:</strong> Totally 30 patients with 27 males and 3 females were enrolled. Schamberg’s disease was commonest type noted in 21patients. Eczematoid, lichen aureus, and lichenoid types were seen in 2 (6.7%) each. Hence, overall occurrence of Schamberg’s disease was statistically significant (p=0.028). Commonest dermoscopic findings were brown pigment network and yellowish-brown dots/globules. Least common features included linear vessels and bluish globules. Distorted pigment network noted in 29 (96.7%).</p><p class="abstract"><strong>Conclusions:</strong> Dermoscopy of PPPD shows characteristic patterns of which pigment network, red globules and yellowish-brown globules are the basic features. These features correlate well with histopathological changes. Yellowish-brown globules and background are prominently observed in skin of color. Larger studies are recommended to validate these differences.</p><p class="abstract"> </p>
Estamos em atraso?: Uma análise de dados sobre a institucionalização da Pós-Graduação do Direito e das Ciências Humanas e Sociais Aplicadas no Brasil
Authors: Pimenta Filho Luiz Cláudio , Sales Fernando Romani , Dantas Maia Gabriel 
Published: August 2022

O artigo tem por objetivo apresentar uma comparação entre dados da pós-graduação no Direito e nas Ciências Humanas e Sociais Aplicadas no Brasil. Para tanto, pretende-se descrever dados coletados em bases disponibilizadas pela CAPES até o ano de 2018. O trabalho parte da hipótese levantada por Marcos Nobre em 2003 de que o Direito apresentaria um “atraso relativo” da pesquisa científica em comparação às demais Ciências Humanas e Sociais Aplicadas. A análise não tem por foco a possível questão teórico-epistemológica deste atraso, mas sim as dificuldades da institucionalização da pesquisa científica no Direito, conforme apontada por Roberto da Silva Fragale Filho e Alexandre Veronese em 2004 e detalhada por Alexandre Veronese em 2007. A descrição destes dados tem por objetivo verificar em que medida as hipóteses levantadas na literatura encontram fundamento nos dados, bem como melhor caracterizar os problemas relativos a essa baixa institucionalização. A conclusão é de que os dados demonstram uma substancial diferença entre o Direito e as demais áreas, o que dá suporte aos diagnósticos levantados na literatura.
TRAVELOGUE AND CREATIVE EASY SPARKLINGS
Authors: Virk Farhat Jabeein , Ali Zulfiqar , Nighat Fareeha 
Published: August 2022

Purpose of the study: This study aims to highlight the importance of travelogue and Poetry.
Methodology: The article explains the travelogue and poetry with the help of multiple references applying analytical research methodology.
Main Findings: To get closer to any work of art means to be better reflected in life, as a result of which its greatness is acknowledged as well. If Ghalib was bent on giving his whole diwan for one verse of Momin, it was because of the vast study of the Momin. In any genre of literature, deep observation is of fundamental importance. Without deep observation, no piece of literature can be accepted. Today, the rise of the Azad Nazm and travelogue in poetry is also because the writers of these genres have seen the world around them with their open eyes by realizing every scenario with its components. Efforts have been made after examining life to draw intellectual conclusions from it.
Об этимологических и семантических соответствиях русской лексемы "гордость" в славянских языках
Authors: Стефанский Евгений 
Published: August 2022

В статье анализируется славянская лексика, обозначающая ‘гордость’. При этом, с одной стороны, рассматриваются лексемы, передающие данное понятие в разных славянских языках, и их ценностные характеристки. С другой – анализируются семантические процессы, которые привели к тому, что слова, восходящие к праславянскому корню *gr̥d-, в ряде славянских языков изменили свое значение.
Материал для исследования собирался на основе параллельных текстов (оригиналов и переводов) и национальных корпусов славянских языков. Применялись сопоставительный, сравнительно-исторический, системноструктурный методы.
Анализ показал, что только русский и болгарский литературные языки не развили энантиосемию корня *gr̥d-. В западнославянских языках энантиосемия корня *gr̥d- развилась в сторону семантики презрения, однако данный корень активно продолжает использоваться для обозначения позитивной гордости. Одновременно для передачи негативной гордости в этих языках употребляется корень *pych-. Украинский и белорусский языки развили аналогичную западнославянским языкам энантиосемию и получили в качестве центрального средства обозначения негативной гордости корень *pych-, но сохранили, как в русском языке, корень *gr̥d- для передачи как негативной, так и позитивной гордости. Сербский, хорватский и словенский языки развили энантиосемию корня *gr̥d- в сторону значения ‘уродливый’, для обозначения положительной гордости в них используется лексема ponos и ее дериваты, негативная гордость выражается с помощью заимствованного из русского корня -горд-.
Państewko Gabriele d’Annunzio — ustrój Włoskiej Regencji Carnaro
Authors: Rakowski Maciej 
Published: August 2022

The subject of the study is the constitutional regime of the independent city of Fiume during the authoritarian rule of Gabriele D’Annunzio (September 1919 — December 1920). His power was based not on legal norms, but on the will of the commander known as the prophet (vate) or the leader (duce), supported by the strength of his army. Nevertheless, in September 1920, D’Annunzio proclaimed the Charter of Kvarner — the constitution of the small state, which never came into force. The author analyzes its provisions using the formal-dogmatic approach, pointing to the modernity and originality of its regulations: gender equality, guarantees of social rights, protection of work, secularity of education, society divided into corporations, elements of direct democracy, division of powers between legislative chambers, and a lack of the head of state. Constitutional institutions are presented with consideration of the history of Fiume, studied by the historical approach.
The author concludes that D’Annunzio did not belong to the fascist movement, but was rather a rival of Mussolini, with a different vision of the state and methods of rule. His Charter of Kvarner can therefore be seen as a concept for the new Italy. At the same time, the commandant was a forerunner of the methods of communicating with society which were later used by the leaders of totalitarian states.
Éthique et réglementation en expérimentation animale en France : éléments de réflexion à partir des expérimentations sur les bovins
Authors: VEISSIER Isabelle , DEISS Véronique 
Published: August 2022

L'expérimentation animale est autorisée à condition qu'aucun autre moyen d'acquérir des connaissances importantes n’est possible et que la souffrance des animaux est limitée. Chaque chercheur se doit d’évaluer la pertinence de l’utilisation des animaux ainsi que les dommages que son expérimentation risque d’imposer aux animaux, et mettre ces dommages en regard de l’intérêt des résultats escomptés. Il existe désormais des grilles pour évaluer la douleur dans de nombreuses espèces, dont les animaux d’élevage, ainsi que des moyens de savoir si une situation peut être perçue comme contraignante par un animal. La règle des 3R (remplacer, réduire, raffiner) préconise de réduire au maximum les dommages causés aux animaux en recourant à des méthodes d’exploration ne nécessitant pas d’expérimentation sur animaux vivants dès qu’une telle alternative existe, en réduisant les effectifs animaux au minimum nécessaire pour obtenir des résultats exploitables et en améliorant les procédures. Il reste difficile d’évaluer l’équilibre entre dommages pour les animaux et bénéfices des résultats attendus. Nous proposons d’évaluer la pertinence d’une expérimentation à l’aide de cinq critères : i) l’existence d’une stratégie 3R, ii) l’application des 3R dans l’expérimentation prévue, iii) les préjudices imposés aux animaux, iv) l’importance des résultats attendus, v) la probabilité d’obtenir des résultats exploitables. Dans une dernière partie, nous rappelons la règlementation en vigueur : mise en place de comités d’éthique évaluant les projets d’expérimentation, agrément des établissements hébergeurs d’animaux, formation des personnels, mise en place de structures chargées du bien-être des animaux au sein des établissements. Nous fournissons quelques clés qui aideront les chercheurs à établir leurs demandes d’autorisation d’une expérimentation.
Rôle et impact environnemental du cuivre et du zinc en élevage porcin : de l’alimentation au retour au sol des effluents
Authors: GOURLEZ EMMA , BÉLINE Fabrice , DOURMAD Jean-Yves , MONTEIRO Alessandra , DE QUELEN Francine 
Published: August 2022

Le zinc et le cuivre sont des éléments-traces métalliques (ÉTM) qui peuvent présenter à plus ou moins long terme un risque environnemental pour les sols agricoles sur lesquels sont valorisées les déjections porcines. Ces ÉTM sont essentiels pour la croissance et la santé des porcs en élevage, ils sont donc ajoutés dans l’aliment sous forme de supplémentation. Cependant, du fait de leur faible taux de rétention chez le porc, ils se retrouvent très majoritairement excrétés dans les déjections. De plus, ce sont des ressources minérales naturelles limitées. Il est alors essentiel de caractériser leurs flux le long du continuum aliments-déjections-traitements-sols afin de maîtriser au mieux leur utilisation. Un état des lieux des connaissances sur ces flux montre que l’alimentation est le principal levier pour limiter les rejets de ces ETM vers l’environnement. La réglementation européenne fixe actuellement des teneurs limites des aliments en zinc et en cuivre (e.g. pour un porc en engraissement, 120 et 25 mg.kg- 1 MS respectivement). Le traitement des déjections est un second levier pour optimiser la valorisation de ces effluents d’élevage et mieux gérer la redistribution de ces ÉTM sur les sols, en les concentrant dans certains produits plus facilement exportables vers des zones en déficit. Une meilleure connaissance de leur forme chimique tout au long de la filière est aussi nécessaire pour mieux maîtriser leur devenir et préciser les risques pour l’environnement. Des recherches restent nécessaires pour affiner les stratégies d’apport dans les aliments, tout en conservant les performances et la santé des animaux et en prenant en compte les différentes modalités de gestion des effluents dans le cadre d’une bioéconomie circulaire.
Eutherian comparative genomic analysis protocol
Authors: Premzl Marko 
Published: August 2022

Abstract
The eutherian genomics momentum greatly advanced biological and medical sciences. Yet, future revisions and updates of eutherian genomic sequence data sets were expected, due to potential genomic sequence errors and incompleteness of genomic sequences. Importantly, the human protein coding gene census remained unfinished: contemporary estimates included ≈ 20000-21000 protein coding genes in human genome, in contrast to human initial integrated gene index that included ≈ 32000 known and predicted protein coding genes. The eutherian comparative genomic analysis protocol was established as one framework of eutherian gene data set descriptions. The protocol revised, updated and published 14 major eutherian gene data sets, including 2615 complete coding sequences deposited in European Nucleotide Archive as curated third party data gene data sets under accession numbers: FR734011-FR734074, HF564658-HF564785, HF564786-HF564815, HG328835-HG329089, HG426065-HG426183, HG931734-HG931849, LM644135-LM644234, LN874312-LN874522, LT548096-LT548244, LT631550-LT631670, LT962964-LT963174, LT990249-LT990597, LR130242-LR130508 and LR760818-LR761312.