bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gravity and Remote Sensing Methods as a Solution in Identifying Geothermal Reservoirs on Volcanoes
Authors: Wiyono  , Siombone Salman Hamja , Maryanto Sukir 
Published: September 2022

Tiris Village, Lamongan Volcano complex is an area that has geothermal potential. The existence of geothermal potential in this study was identified using the gravity method combined with remote sensing methods. Remote sensing method is used to obtain a map of the distribution pattern of the soil surface temperature and a map of the continuity of the straightness and fault structure. The data used in the remote sensing method is secondary data in the form of Landsat-8 imagery and DEM SRTM 1 arc. Processing of the soil surface temperature map was obtained by using thermal infrared processing NDVI. The form of continuity of the straightness or fault structure is obtained by processing Landsat-8 multispectral image data in the form of 567 band composite and DEM SRTM data form of 3D topographic modeling. The data from the composite band 567 was reviewed visually using a 3D topographic model. The gravity method is the main method in this research because it is used to obtain the residual Bouguer anomaly distribution. The residual Bouguer anomaly data was obtained by using the moving average through spectrum analysis. The residual Bouguer anomaly distribution can be used for qualitative interpretation of the distribution of the earth’s gravitational acceleration at the measurement location. The quantitative interpretation of the gravity data is based on the surface density estimation graph using the Parasnis method and 3D inversion modeling, using residual Bouguer anomaly data. The results of 3D inversion modeling provide four types of subsurface rock layers based on the density distribution value, namely, the first rock layer

ρ

1

=
2.52
–
2.67

g/cm3, the second rock layer

ρ

2

=
2.72
–
2.77

g/cm3, the third rock layer

ρ

3

=
2.80
–
2.83

g/cm3, and the fourth rock layer

ρ

4

=
2.84
–
2.86

g/cm3. The third rock layer is assumed to be reservoir rock and is estimated to be at a depth of 500–800 meters below the measurement point. The fourth rock layer is assumed to be intrusive igneous rock, which penetrates dominantly in the middle of the measurement location, which is oriented southwest, south to north, which is indicated by the high anomaly continuity on the regional Bouguer anomaly map. Based on the results of 3D inversion modeling and spectrum analysis of the average depth of the regional Bouguer anomaly, it is found that the intrusive rock layer is thought to be at a depth of 350 meters below the measurement point.
Loss of MLL Induces Epigenetic Dysregulation of Rasgrf1 to Attenuate Kras-Driven Lung Tumorigenesis
Authors: Zhu Ling-Yu , Yuan Jun-Bo , Zhang Li , He Chun-Xiao , Lin Xiao , Xu Bin , Jin Guang-Hui 
Published: September 2022

Abstract

Menin is necessary for the formation of the menin/mixed lineage leukemia (MLL) complex and is recruited directly to chromatin. Menin is an important tumor suppressor in several cancer types, including lung cancer. Here, we investigated the role of MLL in menin-regulated lung tumorigenesis. Ablation of MLL suppressed KrasG12D-induced lung tumorigenesis in a genetically engineered mouse model. MLL deficiency decreased histone H3 lysine 4 trimethylation (H3K4me3) and subsequently suppressed expression of the Ras protein-specific guanine nucleotide-releasing factor 1 (Rasgrf1) gene. Rasgrf1 was essential for the GTP-bound active state of Kras and the activation of Kras downstream pathways as well as their cancer-promoting activities. MI-3, a small-molecule inhibitor targeting MLL, specifically inhibited the growth of Kras-mutated lung cancer cells in vitro and in vivo with minimal effect on wild-type Kras lung cancer growth. Together, these results demonstrate a novel tumor promoter function of MLL in mutant Kras-induced lung tumorigenesis and further indicate that specific blockade of the MLL-Rasgrf1 pathway may be a potential therapeutic strategy for the treatment of tumors containing Kras mutations.

Significance:
Activation of mutant Kras is dependent on MLL-mediated epigenetic regulation of Rasgrf1, conferring sensitivity to small-molecule inhibition of MLL in Kras-driven lung cancer.
Risk of Colorectal Cancer and Colorectal Cancer Mortality Beginning Ten Years after a Negative Colonoscopy, among Screen-Eligible Adults 76 to 85 Years Old
Authors: Dalmat Ronit R. , Ziebell Rebecca A. , Kamineni Aruna , Phipps Amanda I. , Weiss Noel S. , Breslau Erica S. , Corley Douglas A. , Green Beverly B. , Halm Ethan A. , Levin Theodore R. , Schottinger Joanne E. , Chubak Jessica 
Published: September 2022

Abstract

Background:
Few empirical data are available to inform older adults’ decisions about whether to screen or continue screening for colorectal cancer based on their prior history of screening, particularly among individuals with a prior negative exam.

Methods:
Using a retrospective cohort of older adults receiving healthcare at three Kaiser Permanente integrated healthcare systems in Northern California (KPNC), Southern California (KPSC), and Washington (KPWA), we estimated the cumulative risk of colorectal cancer incidence and mortality among older adults who had a negative colonoscopy 10 years earlier, accounting for death from other causes.

Results:
Screen-eligible adults ages 76 to 85 years who had a negative colonoscopy 10 years earlier were found to be at a low risk of colorectal cancer diagnosis, with a cumulative incidence of 0.39% [95% CI, 0.31%–0.48%) at 2 years that increased to 1.29% (95% CI, 1.02%–1.61%) at 8 years. Cumulative mortality from colorectal cancer was 0.04% (95% CI, 0.02%–0.08%) at 2 years and 0.46% (95% CI, 0.30%–0.70%) at 8 years.

Conclusions:
These low estimates of cumulative colorectal cancer incidence and mortality occurred in the context of much higher risk of death from other causes.

Impact:
Knowledge of these results could bear on older adults’ decision to undergo or not undergo further colorectal cancer screening, including choice of modality, should they decide to continue screening.
See related commentary by Lieberman, p. 6
Intraperitoneal Monocytes plus IFNs as a Novel Cellular Immunotherapy for Ovarian Cancer: Mechanistic Characterization and Results from a Phase I Clinical Trial
Authors: Green Daniel S. , Ning Franklin , Duemler Anna , Myers Timothy G. , Trewhitt Kathryn , Ekwede Irene , McCoy Ann , Houston Nicole , Lee Jung-min , Lipkowitz Stanley , Zimmer Alexandra , Pavelova Miroslava , Villanueva Erin N. , Smith Leslie , Blakely Andrew , Casablanca Yovanni , Highfill Steven L. , Stroncek David F. , Collins-Johnson Naoza , Panch Sandhya , Procter JoLynn , Pham Chauha , Korrapati Soumya , Holland Steven M. , Rosen Lindsey B. , Nunes Ana T. , Zoon Kathryn C. , Cole Christopher B. , Annunziata Christina M. 
Published: September 2022

Abstract

Purpose:
Ovarian cancer is the most lethal gynecologic cancer and intrinsically resistant to checkpoint immunotherapies. We sought to augment innate immunity, building on previous work with IFNs and monocytes.

Patients and Methods:
Preclinical experiments were designed to define the mechanisms of cancer cell death mediated by the combination of IFNs α and γ with monocytes. We translated these preclinical findings into a phase I trial of autologous IFN-activated monocytes administered intraperitoneally to platinum-resistant or -refractory ovarian cancer patients.

Results:
IFN-treated monocytes induced caspase 8–dependent apoptosis by the proapoptotic TRAIL and mediated by the death receptors 4 and 5 (DR4 and DR5, respectively) on cancer cells. Therapy was well tolerated with evidence of clinical activity, as 2 of 9 evaluable patients had a partial response by RECIST criteria, and 1 additional patient had a CA-125 response. Upregulation of monocyte-produced TRAIL and cytokines was confirmed in peripheral blood. Long-term responders had alterations in innate and adaptive immune compartments.

Conclusions:
Given the mechanism of cancer cell death, and the acceptable tolerability of the clinical regimen, this platform presents a possibility for future combination therapies to augment anticancer immunity.
See related commentary by Chow and Dorigo, p. 299
Extracellular Vesicles Regulate Sympatho-Excitation by Nrf2 in Heart Failure
Authors: Tian Changhai , Gao Lie , Rudebush Tara L. , Yu Li , Zucker Irving H. 
Published: September 2022

Background:
Chronic heart failure (CHF) is associated with redox imbalance. Downregulation of Nrf2 (nuclear factor [erythroid-derived 2]-like 2) plays important roles in disrupting myocardial redox homeostasis and mediating sympathetic nerve activity in the setting of CHF. However, it is unclear if circulating extracellular vesicles (EVs) elicit sympathetic excitation in CHF by disrupting central redox homeostasis. We tested the hypothesis that cardiac-derived EVs circulate to the presympathetic rostral ventrolateral medulla and contribute to oxidative stress and sympathetic excitation via EV-enriched microRNA-mediated Nrf2 downregulation.

Methods:

Data were collected on rats with CHF post–myocardial infarction (MI) and on human subjects with ischemic CHF. EVs were isolated from tissue and plasma, and we determined the miRNAs cargo that related to targeting Nrf2 translation. We tracked the distribution of cardiac-derived EVs using in vitro labeled circulating EVs and cardiac-specific membrane GFP
+
transgenic mice. Finally, we tested the impact of exogenously loading of antagomirs to specific Nrf2-related miRNAs on CHF-EV–induced pathophysiological phenotypes in normal rats (eg, sympathetic and cardiac function).

Results:
Nrf2 downregulation in CHF rats was associated with an upregulation of Nrf2-targeting miRNAs, which were abundant in cardiac-derived and circulating EVs from rats and humans. EVs isolated from the brain of CHF rats were also enriched with Nrf2-targeting miRNAs and cardiac-specific miRNAs. Cardiac-derived EVs were taken up by neurons in the rostral ventrolateral medulla. The administration of cardiac-derived and circulating EVs from CHF rats into the rostral ventrolateral medulla of normal rats evoked an increase in renal sympathetic nerve activity and plasma norepinephrine compared with Sham-operated rats, which were attenuated by exogenously preloading CHF-EVs with antagomirs to Nrf2-targeting miRNAs.

Conclusions:
Cardiac microRNA-enriched EVs from animals with CHF can mediate crosstalk between the heart and the brain in the regulation of sympathetic outflow by targeting the Nrf2/antioxidant signaling pathway. This new endocrine signaling pathway regulating sympathetic outflow in CHF may be exploited for novel therapeutics.
Justice in Negotiating: How and Where to Find It and Use It
Authors: Zartman I. William 
Published: September 2022

Abstract
Conflict over justice is the basis of negotiation, as the parties search for an outcome that is just enough, both to be preferable to their initial, but unilaterally unreachable, priorities and to the alternative of continued conflict. They do this in preparation for negotiating the exchange or division of items contested between them; the parties come to an agreement on the notion of justice that will govern this disposition. If they do not, the negotiations will not be able to proceed to a conclusion. Conflicting notions of justice act as a substantive veto on agreement and must be coordinated and accepted as the first stage of negotiation. The resulting notion of justice constitutes a formula, general principles defining the nature of the process, including the nature of the problem and the terms of trade. Ten historical cases are considered.
Confidence in Pragmatism: An Invitation to Public Dialogue
Authors: Crump Julius 
Published: September 2022

Abstract
Richard Rorty’s idealization of public dialogue pits literature and narrative against objectivity and ethics, thus leaving non-intellectual practitioners in the lurch. The evolutionary arc of Rorty’s oeuvre merits an assessment of the historiography he uses to prevent figures like Michel Foucault and Cornel West from being full participants in public dialogue. Miranda Fricker’s account of the collective explains confidence and transparency in an ironized ethical tradition that mediates irony and objectivity. Fricker’s mediation positions West’s use of Foucault’s to re-narrate pragmatism as a way to embrace the process of rendering ethical experience universalizable. Ironized post-philosophical cultures can be explained responsibly by ironists within critically reflective ethical traditions. Confidence in pragmatism occurs when publics admit critical self-reflective inquiry from non-intellectuals.
A Sea Surface–Based Drag Model for Large-Eddy Simulation of Wind–Wave Interaction
Authors: Aiyer Aditya K. , Deike Luc , Mueller Michael E. 
Published: September 2022

Abstract
Monin–Obukhov similarity theory (MOST) is a well-tested approach for specifying the fluxes when the roughness surfaces are homogeneous. For flow over waves (inhomogeneous surfaces), phase-averaged roughness length scales are often prescribed through models based on the wave characteristics and the wind speed. However, such approaches lack generalizability over different wave ages and steepnesses due to the reliance on model coefficients tuned to specific datasets. In this paper, a sea surface–based hydrodynamic drag model applicable to moving surfaces is developed to model the pressure-based surface drag felt by the wind due to the waves. The model is based on the surface gradient approach of Anderson and Meneveau applicable to stationary obstacles and extended here to the wind–wave problem. The wave drag model proposed specifies the hydrodynamic force based on the incoming momentum flux, wave phase speed, and the surface frontal area. The drag coefficient associated with the wind–wave momentum exchange is determined based on the wave steepness. The wave drag model is used to simulate turbulent airflow above a monochromatic wave train with different wave ages and wave steepnesses. The mean velocity profiles and model form stresses are validated with available laboratory-scale experimental data and show good agreement across a wide range of wave steepnesses and wave ages. The drag force is correlated with the wave surface gradient and out-of-phase with the wave height distribution by a factor of π/2 for the sinusoidal wave train considered. These results demonstrate that the current approach is sufficiently general over a wide parameter space compared to wave phase-averaged models with a minimal increase in computational cost.

Significance Statement
Understanding the physics of wind waves plays an important role in the context of numerous geophysical and engineering applications. A drag-based model is developed that characterizes the effect of the sea surface waves on the wind above. The model is validated with existing experimental datasets and is shown to be effective in predicting the average wind velocity and stress over waves with varied steepnesses and phase speeds. The ease of implementation and low computational cost of the model make it useful for studying turbulent atmospheric-scale flows over the sea surface important in offshore wind energy research as well as for modeling air–sea fluxes of momentum, heat, and mass.
Studies of Stable Stratification Effect on Dynamic and Thermal Roughness Lengths of Urban-Type Canopy Using Large-Eddy Simulation
Authors: Glazunov Andrey , Mortikov Evgeny , Debolskiy Andrey 
Published: September 2022

Abstract
Large-eddy simulations (LES) of neutrally and stably stratified turbulent flows over urban-type surfaces with relatively low plan area ratios are presented. Numerical experiments were performed for different shapes of streamlined objects and at different static stability. A new method for setting up a numerical experiment aimed at studying the heat and momentum transfer within the roughness layer and investigating the thermal and dynamic interaction between the turbulent flow and the surface as a whole has been proposed. This method enables us to obtain an equilibrium state for values of parameters determining the characteristics of the external turbulent flow chosen beforehand. A strong dependence of the thermal roughness length on stratification was found. We also discuss the physical mechanisms that lead to the maintenance of turbulence above the canopy when the ground surface is strongly cooled.

Significance Statement
Using LES, we identify a mechanism that contributes to the maintenance of turbulence in the atmospheric boundary layer under the condition of strong surface cooling. Although these results are obtained for an urban canopy, we believe that the qualitative conclusions should be general for a wide type of surfaces with large-scale roughness elements. We hope that the new results will be useful for improving surface flux schemes in NWP and climate atmospheric models that suffer from attenuated mixing in a very stable boundary layer and the effect of “surface decoupling.” The found effect gives a physically justified alternative way to parameterize the air–surface exchange under strong stability compared to the often ad hoc modification of the MOST universal functions.
Prophylactic Intraoperative Antibiotic Dosing in Head and Neck Surgery: Opportunities for Improvement and Future Study
Authors: Shah Rema , Cohen Oded , Panth Neelima , Dibble Jacqueline , Paolillo Danielle , Cook Amanda , Mehra Saral 
Published: September 2022

AbstractObjectivesTo investigate rates of Surgical Care Improvement Project (SCIP) guideline adherence with regard to intraoperative antibiotic prophylaxis in head and neck surgery with free tissue transfer.Study DesignRetrospective case series.SettingA single academic center.MethodsAll patients who underwent mucosa‐violating head and neck oncologic surgery with free tissue transfer between March 2017 and June 2019 were reviewed. Intraoperative antibiotic data included type, dosage, frequency of administration, and duration. Any deviation from SCIP recommendations was defined as nonadherence. Antibiotic type was categorized as ampicillin‐sulbactam, cefazolin/metronidazole, clindamycin, and others. As a secondary exploratory analysis, postoperative infections were analyzed and stratified by adherent vs nonadherent and by antibiotic type.ResultsA total of 129 surgical procedures were included. The mean ± SD number of antibiotic doses during surgery was 3.16 ± 1.2. The mean number of missed doses was 1.86 ± 1.65. Adherence rate with first dosing recommendation was 100%, as compared with 41.7% for dose 2, 23.1% for dose 3, 13.7% for dose 4, 5.26% for dose 5, 2.56% for dose 6, and 0% for dose 7 (P < .001). Ampicillin‐sulbactam (6.4%) had a significantly lower rate of average redosing adherence when compared with cefazolin/metronidazole (73.2%) and clindamycin (63.3%; P < .001).ConclusionSignificant opportunities exist in SCIP guideline adherence rates for intraoperative antibiotic prophylaxis. Cefazolin/metronidazole had a significantly higher rate of appropriate redosing when compared with ampicillin‐sulbactam, which should be considered when choosing a prophylactic antibiotic regimen and performing antibiotic‐based outcomes studies. More attention should be given to intraoperative antibiotic prophylaxis in head and neck surgery with free tissue transfer, as this presents an opportunity for quality improvement and future study heretofore not explored.
Acute effect of resistance exercise at different velocities on stiffness and vascularity of the biceps brachii muscle: a preliminary study
Authors: Ustabaşıoğlu Fethi Emre , Ağırdemir Fatma Ebru , Ustabaşıoğlu Fatma , Sunal Baran Serdar 
Published: September 2022

Background Resistance exercise can be defined as the percentage of maximal strength (%1 repetition maximum) used for a particular exercise. Shear wave elastography (SWE) is a robust and novelty imaging technique that provides information regarding tissue stiffness. Superb microvascular imaging (SMI) is a non-irradiating technique that can provide quantitative measurement of muscle blood flow non-invasively. Purpose To compare the acute effects of low- and high-velocity resistance exercise on stiffness and blood flow in the biceps brachii muscle (BBM) using SWE and SMI. Material and Methods This prospective study included 60 healthy men (mean age=28.9 years; age range=26–34 years). BBM stiffness was measured by using SWE at rest, after low- and high-velocity resistance exercise, and muscle blood flow was also evaluated by SMI. Resistance exercise was performed using a dumbbell with a mass adjusted to 70%–80% of one-repetition maximum. Results The stiffness values increased significantly from resting to high- and low-velocity resistance exercises. There was no significant difference between the elastography values of the BBM after the high- and low-velocity resistance exercise. The blood flow increased significantly from resting to high- and low-velocity resistance exercises. Blood flow increase after low-velocity exercise was significantly higher compared to high-velocity exercise. Conclusion While muscle stiffness parameters and blood flow significantly increased from resting after both high- and low-velocity resistance exercises, blood flow significantly increased after low-velocity exercise compared to high-velocity exercise. This can mean that metabolic stress, an important trigger for muscle development, is more likely to occur in low-velocity exercise.