bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebrospinal fluid neurofilament light chain differentiates primary psychiatric disorders from rapidly progressive, Alzheimer's disease and frontotemporal disorders in clinical settings
Authors: Eratne Dhamidhu , Loi Samantha M. , Li Qiao‐Xin , Stehmann Christiane , Malpas Charles B. , Santillo Alexander , Janelidze Shorena , Cadwallader Claire , Walia Nirbaanjot , Ney Blair , Lewis Victoria , Senesi Matteo , Fowler Christopher , McGlade Amelia , Varghese Shiji , Ravanfar Parsa , Kelso Wendy , Farrand Sarah , Keem Michael , Kang Matthew , Goh Anita M.Y. , Dhiman Kunal , Gupta Veer , Watson Rosie , Yassi Nawaf , Kaylor‐Hughes Cath , Kanaan Richard , Perucca Piero , Dobson Hannah , Vivash Lucy , Ali Rashida , O'Brien Terence J. , Hansson Oskar , Zetterberg Henrik , Blennow Kaj , Walterfang Mark , Masters Colin L. , Berkovic Samuel F. , Collins Steven , Velakoulis Dennis ,   The MiND Study Group
Published: February 2022

AbstractIntroductionMany patients with cognitive and neuropsychiatric symptoms face diagnostic delay and misdiagnosis. We investigated whether cerebrospinal fluid (CSF) neurofilament light (NfL) and total‐tau (t‐tau) could assist in the clinical scenario of differentiating neurodegenerative (ND) from psychiatric disorders (PSY), and rapidly progressive disorders.MethodsBiomarkers were examined in patients from specialist services (ND and PSY) and a national Creutzfeldt‐Jakob registry (Creutzfeldt‐Jakob disease [CJD] and rapidly progressive dementias/atypically rapid variants of common ND, RapidND).ResultsA total of 498 participants were included: 197 ND, 67 PSY, 161 CJD, 48 RapidND, and 20 controls. NfL was elevated in ND compared to PSY and controls, with highest levels in CJD and RapidND. NfL distinguished ND from PSY with 95%/78% positive/negative predictive value, 92%/87% sensitivity/specificity, 91% accuracy. NfL outperformed t‐tau in most real‐life clinical diagnostic dilemma scenarios, except distinguishing CJD from RapidND.DiscussionWe demonstrated strong generalizable evidence for the diagnostic utility of CSF NfL in differentiating ND from psychiatric disorders, with high accuracy.
Ovariectomized rat model and shape variation in the bony labyrinth
Authors: Ward Devin L. , Schroeder Lauren , Tinius Alexander , Niccoli Sarah , Voth Riley , Lees Simon J. , Silcox Mary , Viola Bence , Sanzo Paolo 
Published: February 2022

AbstractPostmenopausal osteoporosis is a serious concern in aging individuals, but has not been explored for its potential to alter the shape of the inner ear by way of increased remodeling in the otic capsule. The otic capsule, or bony labyrinth, is thought to experience uniquely limited remodeling after development due to high levels of osteoprotegerin. On this basis, despite the widespread remodeling that accompanies osteoporosis, we hypothesize that both the shape and volume of the semicircular canals will resist such changes. To test this hypothesis, we conducted three‐dimensional geometric morphometric shape analysis on microcomputed tomographic data collected on the semicircular canals of an ovariectomized (OVX) rat model. A Procrustes ANOVA found no statistically significant differences in shape between surgery and sham groups, and morphological disparity testing likewise found no differences in shape variation. Univariate testing found no differences in semicircular volume between OVX and control groups. The range of variation in the OVX group, however, is greater than in the sham group but this difference does not reach statistical significance, perhaps because of a combination of small effect size and low sample size. This finding suggests that labyrinthine shape remains a tool for assessing phylogeny and function in the fossil record, but that it is possible that osteoporosis may be contributing to intraspecific shape variation in the bony labyrinth. This effect warrants further exploration at a microstructural level with continued focus on variables related to remodeling.
Anwendungsmöglichkeiten der neuen „Muster‐Holzbaurichtlinie” für Holzrahmenbauteile
Authors: Scheidel Sabine , Dienst Sebastian , Kornadt Oliver 
Published: February 2022

AbstractIn der Baubranche, wie auch in vielen anderen Bereichen, legen Politik und Gesellschaft immer stärkere Priorität auf ein nachhaltiges, ressourcenschonendes und ökologisches Denken und Handeln. Zur Errichtung und Erweiterung von Gebäuden ist Holz hier als besonders geeignet zu sehen, was auch die Charta für Holz verdeutlicht. Im Juni dieses Jahres wurde die neue Muster‐Richtlinie über brandschutztechnische Anforderungen an Bauteile und Außenwandbekleidungen in Holzbauweise (MHolzBauR) durch die Aufnahme in die Muster‐Verwaltungsvorschrift Technische Baubestimmungen (MVV TB) eingeführt. Bereits vor der offiziellen Einführung wurde diese als ein weiterer Schritt in Richtung der bauaufsichtlich geregelten Holzgebäude bis zur Gebäudeklasse 5 gewertet. Die Richtlinie soll die Anwendung von Holz als Baustoff über eine Geschosshöhe von 13 m hinaus zulässig machen und auch eine Ausführung tragender und raumabschließender Bauteile mit einer feuerbeständigen Anforderung in Holzbauweise ermöglichen. Bei einem Vergleich der neuen MHolzBauR mit der bisher gültigen Muster‐Richtlinie erkennt man jedoch keinen nennenswerten Unterschied zwischen den brandschutztechnischen Anforderungen an eine Holzrahmenkonstruktion. Damit können die lang ersehnten Möglichkeiten für Holzgebäude bis zur Hochhausgrenze nur in Massivholzbauweise realisiert werden. Ein nicht unerheblicher Bereich des Holzbaus bleibt weiterhin auf die Gebäudeklasse 4 begrenzt.
Childhood cancer risk in offspring of parents occupationally exposed to dusts: A register‐based nested case‐control study from Sweden of 5 decades
Authors: Rossides Marios , Kampitsi Christina‐Evmorfia , Talbäck Mats , Wiebert Pernilla , Feychting Maria , Tettamanti Giorgio 
Published: February 2022

BackgroundSome largely inconsistent associations between parental occupational dust exposure and childhood cancer have been reported, with maternal exposures inadequately studied. The authors examined whether maternal or paternal occupational exposure to animal, wood, textile, or paper dust around a child's birth was associated with an increased risk of childhood cancer, both overall and by type (leukemias, lymphomas, central nervous system tumors, and other cancers).MethodsIn this nationwide, register‐based, case‐control study, children who were diagnosed with cancer from 1960 to 2015 were compared with up to 25 matched controls regarding maternal and paternal occupational dust exposure (9653 cases in maternal analyses and 12,521 cases in paternal analyses). Exposures were assessed using a job‐exposure matrix and occupational information from census and register data. By using conditional logistic regression models, adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated.ResultsNeither maternal nor paternal occupational exposure to animal, wood, textile, or paper dust was associated with childhood cancer overall, leukemias, or central nervous system tumors. Maternal, but not paternal, wood dust exposure was associated with an increased risk of lymphoma (OR, 1.42; 95% CI, 1.10‐1.84), particularly non‐Hodgkin lymphoma (OR, 2.03; 95% CI, 1.21‐3.40).ConclusionsThe current study did not confirm the associations reported previously but is the first to suggest a link between maternal occupational exposure to wood dust around pregnancy and lymphoma in the offspring.
Mindfulness‐based and mindfulness‐informed interventions in bipolar disorder: A meta‐analysis based on Becker's method
Authors: Burgos‐Julián Francisco A. , Ruiz‐Íñiguez Raquel , Peña‐Ibáñez Fernando , Montero Ana Carralero , Santed‐Germán Miguel Angel 
Published: February 2022

AbstractBipolar disorder is a highly disruptive and debilitating problem. Mindfulness‐based and mindfulness‐informed interventions have exponentially emerged as third‐generation therapies, applied to a wide spectrum of disorders, including bipolar disorder. However, the reviews and meta‐analyses published to date are limited in their conclusions, as they are based on single‐group pretest–posttest cohort designs and mostly focused on mindfulness‐based interventions. The present review and meta‐analysis try to address these limitations, including studies on informed mindfulness, controlled and single‐group designs. It used a specific meta‐analytical procedure that allows an imputation procedure in those designs lacking a comparison group, by means of separate omnibus tests for the experimental and control group. A total of 13 studies (N = 331) were selected. The results showed an absence of effects on depression (g = 0.21) and mania (g = −0.13), but significant moderate effect on anxiety (g = 0.53). In conclusion, both mindfulness interventions showed robust evidence on anxiety symptoms in pretest–posttest periods compared to control groups. Few studies and lack of evidence of follow‐up periods were the main limitations found.
Coordination of mode switching control and SMES unit for low‐voltage ride‐through fulfillment of power electronic transformer
Authors: Chen Lei , Qiao Xuefeng , Zhao Zekai , Wang Xuechun , Chen Hongkun , Li Yanhong , Islam Md. Rabiul , Deng Xinyi , Li Guocheng 
Published: February 2022

AbstractPower electronic transformer (PET) should have a satisfying low‐voltage ride‐through (LVRT) ability to cope with different kinds and severities of voltage sags. To solve the LVRT issue, this paper proposes to coordinate mode switching control (MSC) and superconducting magnetic energy storage (SMES), and it is to realize the targets of promoting voltage recovery, keeping DC‐link stabilization, and alleviating current inrush. First, the theoretical modeling of a PET incorporating with a SMES unit is implemented, and the PET’s fault transient characterizes as well as the SMES’s potential supportability is analyzed. Then, the coordination philosophy of the MSC and the SMES is presented. For that the voltage sag reaches a certain threshold, the MSC is enabled to remove the PET’s normal control, and the SMES collaboratively operates to lower the DC‐link overvoltage, while avoiding the PET damage. In the process of the coordination control handling the voltage transients, a proper reactive current injection is carried out at the PET’s output stage to assist the voltage recovery, and the PET can possess a better LVRT margin. Using MATLAB, a 3 MW PET with an 8 H/1.2 MJ SMES unit is modeled, and different voltage sag scenarios and utilization ways of the MSC and the SMES are simulated. The comparative analysis results show that the proposed approach realizes a satisfying LVRT for the PET.
Central nervous system organoids for modeling neurodegenerative diseases
Authors: Hou Pei‐Shan , Kuo Hung‐Chih 
Published: February 2022

AbstractRecent advances in induced pluripotent stem cell (iPSC) technology have allowed researchers to generate neurodegenerative disease‐specific iPSCs and use the cells to derive a variety of relevant cell populations for laboratory modeling and drug testing. Nevertheless, these efforts have faced challenges related to immaturity and lack of complex developmental niches in the derived cell populations, limiting the utility of these in vitro models of neurodegenerative disease. Such limitations may be overcome by using human iPSC technology to generate three‐dimensional (3D) brain organoids, which better recapitulate in vivo tissue architecture than traditional neuronal cultures to provide more complex and representative disease models and drug testing systems. In this review, we focus on the application of pluripotent stem cell‐derived central nervous system (CNS) organoids to model neurodegenerative diseases. We first summarize recent progress in generating and characterizing various CNS organoids from pluripotent stem cells. We then review the application of CNS organoids for modeling several different human neurodegenerative diseases. We also describe several novel pathological mechanisms and drugs that were studied using patient iPSC‐derived CNS organoids. Finally, we discuss remaining challenges and emerging opportunities for the use of 3D brain organoids for in vitro modeling of CNS development and neurodegeneration.
Predictive value of NLR and PLR in missed miscarriage
Authors: Liu Dan , Huang Xinyan , Xu Zhengxian , Chen Minzhi , Wu Manyu 
Published: February 2022

AbstractBackgroundThe aim of the study was to investigate the predictive value of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in missed miscarriage.MethodsIn this retrospective cohort study, a total of 400 women (involving 200 with missed early miscarriage and 200 with normal pregnancy but terminate by artificial abortion) were included. General clinical data and complete blood count (CBC) such as white blood cells (WBC), red blood cells (RBC), platelet (PLT), red blood cell distribution width‐standard deviation (RDW‐SD), platelet distribution width (PDW), mean platelet volume (MPV), neutrophil count, and lymphocyte count were collected, and the NLR and PLR were calculated for both groups. Receiver operating characteristic curve (ROC) was used to calculate the predictive value.ResultsThere was no significant difference in the WBC, RBC, PLT, RDW‐SD, PDW, neutrophil, lymphocyte, NLR, and PLR between the two groups (p > 0.05).But MPV was lower in the missed early miscarriage group than in the control group (p < 0.05), and the area under the working curve (AUC) of ROC was 0.58, specificity and sensitivity was 69% and 47%, respectively.ConclusionNLR and PLR were not the suitable indictor for missed miscarriage, but MPV should be a concern in the first trimester.
The impact of storage on extracellular vesicles: A systematic study
Authors: Gelibter Stefano , Marostica Giulia , Mandelli Alessandra , Siciliani Stella , Podini Paola , Finardi Annamaria , Furlan Roberto 
Published: February 2022

AbstractMounting evidence suggests that storage has an impact on extracellular vesicles (EVs) properties. While −80°C storage is a widespread approach, some authors proposed improved storage strategies with conflicting results. Here, we designed a systematic study to assess the impact of −80°C storage and freeze‐thaw cycles on EVs. We tested the differences among eight storage strategies and investigated the possible fusion phenomena occurring during storage. EVs were collected from human plasma and murine microglia culture by size exclusion chromatography and ultracentrifugation, respectively. The analysis included: concentration, size and zeta potential (tunable resistive pulse sensing), contaminant protein assessment; flow cytometry for the analysis of two single fluorescent‐tagged EVs populations (GFP and mCherry), mixed before preservation. We found that −80°C storage reduces EVs concentration and sample purity in a time‐dependent manner. Furthermore, it increases the particle size and size variability and modifies EVs zeta potential, with a shift of EVs in size‐charge plots. None of the tested conditions prevented the observed effects. Freeze‐thaw cycles lead to an EVs reduction after the first cycle and to a cycle‐dependent increase in particle size. With flow cytometry, after storage, we observed a significant population of double‐positive EVs (GFP+‐mCherry+). This observation may suggest the occurrence of fusion phenomena during storage. Our findings show a significant impact of storage on EVs samples in terms of particle loss, purity reduction and fusion phenomena leading to artefactual particles. Depending on downstream analyses and experimental settings, EVs should probably be processed from fresh, non‐archival, samples in majority of cases.
Extensive myelitis with eosinophilic meningitis after Chimeric antigen receptor T cells therapy
Authors: Le Calvez Baptiste , Eveillard Marion , Decamps Paul , Aguilar Jesus , Seguin Amélie , Canet Emmanuel , Grain Audrey , Touzeau Cyrille , Tessoulin Benoît , Gastinne Thomas 
Published: February 2022

AbstractImmune effector cell‐associated neurotoxicity syndrome (ICANS) is a frequent adverse event after Chimeric antigen receptor T cells (CAR‐T cells). A patient treated with anti‐CD19 CAR‐T cells for a refractory mantle cell lymphoma presented at Day 8 post‐infusion with extensive myelitis. Unusual eosinophilia was disclosed in the patient's cerebrospinal fluid. After treatment with methylprednisolone and siltuximab, a decrease in clinical symptoms and magnetic resonance imaging lesions were obtained. This unprecedented presentation of eosinophilic meningitis after CAR‐T cells therapy highlights the need for a better understanding of the physiopathology of ICANS, especially to identify potentially targetable pathways.
Multi‐Crosslinked Hydrogels with Instant Self‐Healing and Tissue Adhesive Properties for Biomedical Applications
Authors: Jiang Yongchao , Li Gaiying , Wang Haonan , Li Qian , Tang Keyong 
Published: February 2022

AbstractDue to the defects like long gelling time, inferior mechanical properties and weak adhesion, in situ forming hydrogels are still restricted in biomedical applications like viscera rupture and targeted therapy. To address these problems, a new kind of multi‐crosslinked hydrogel (G‐OKG‐DA) consisting of gelatin, oxidized konjac glucomannan (OKG), and dopamine (DA) is proposed in this study. The resulting hybrid hydrogel is endowed with a short gelling time (≈3 min) and injectable capacity. According to the mechanical and adhesive tests, G‐OKG‐DA hydrogel shows a robust tensile strength of 23.94 kPa, as well as a higher adhesive strength (≈150 kPa) than commercial fibrin glue. In addition, an instant self‐healing behavior of G‐OKG‐DA hydrogel can be found, which is attributed to multi‐cross‐linking reactions including Schiff‐based dynamic covalent bonds between OKG and gelatin, oxidative polymerization of DA, and catechol‐mediated chemistry like Michael addition and DA–quinone coupling. Importantly, the multi‐crosslinked hydrogel will not compromise its hemocompatibility and cytocompatibility in vitro, suggesting potential applications in biomedical fields as tissue adhesive and implants.
Effect of KCl deposits in high‐temperature corrosion on chromium‐rich steels in SO2‐containing atmosphere
Authors: Kingsbery Phillip , Stephan‐Scherb Christiane 
Published: February 2022

AbstractHigh‐temperature corrosion was studied under multiple chemical loads on ferritic‐austenitic model alloys (Fe–13Cr, Fe–18Cr–12Ni, and Fe‐25Cr–20Ni) with KCl deposit under 0.5% /99.5% Ar gas atmosphere at . Postexposure characterization was done by X‐ray diffraction and scanning electron microscopy. In a pure /Ar environment a protective scale was formed by all samples. The introduction of KCl deposits causes the scale to be nonprotective and multilayered, consisting of CrS, FeS, , and . The impact of the microstructure and alloying elements is discussed.
Recent Progress in Preparation and Application of Fibers Using Microfluidic Spinning Technology
Authors: Zhang Mengfan , Peng Xiaotong , Fan Penghui , Zhou Yingshan , Xiao Pu 
Published: February 2022

AbstractMicroscale fibrous materials with high surface areas and ordered structures have attracted widespread attention recently. Microfluidic spinning technology that can effectively control the sizes, structures, and material compositions of fibers has emerged as a robust approach for the fabrication of high‐performance fibers. In this review, the microfluidic spinning technology used to prepare fibrous materials in terms of preparation principles and geometric configurations is presented. Additionally, several applications of fibers spun by microfluidic spinning technology, especially in tissue engineering, drug release, flexible electronics, water collection, and surgical suturing are introduced. Finally, the current challenges and perspectives of this technology are discussed.
Spatial Adjustment Strategy to Improve the Sensitivity of Ionogels for Flexible Sensors
Authors: Zhang Chao , Yao Miao , Zhao Yingying , Nie Jun , He Yong 
Published: February 2022

AbstractRecently, ionogels‐based flexible/stretchable sensors have been receiving great attention, which greatly promotes the development of artificial flexible electronics. Except transparency, stretchability, stability, self‐healing, and adhesion, the high conductivity of ionogels and high sensitivity as a sensor still are huge challenges. This work proposes a spatial adjustment strategy to improve sensitivity and conductivity through reducing the spatial hinderance without a change in the compound types and ratio. The addition of space pre‐occupier during the preparation of the ionogel reduces the entanglement of polymer chains for better flowability of the polymer network. After removing the solvent from formed ionogels, the obtained free volume could facilitate the movement of ions and mobility of polymers. Through this way, the sensitivity (up to 1.6 times) and conductivity (up to 1.3 times) of ionogels are successfully improved, while maintaining their excellent transparency, stretchability, stability, and electromechanical properties, such as fast response speed and good repeatability. The detecting ability of movements of different parts of the human body is proved. It is worth mentioning that this simple and effective strategy needs no special requirement for chemical structure, so that it has broad applicability in various systems and opens up a new way for the development of flexible sensors.
Deep Learning‐Based Neuromelanin MRI Changes of Isolated REM Sleep Behavior Disorder
Authors: Gaurav Rahul , Pyatigorskaya Nadya , Biondetti Emma , Valabrègue Romain , Yahia‐Cherif Lydia , Mangone Graziella , Leu‐Semenescu Smaranda , Corvol Jean‐Christophe , Vidailhet Marie , Arnulf Isabelle , Lehéricy Stéphane 
Published: February 2022

ABSTRACTBackgroundIsolated REM sleep behavior disorder (iRBD) is considered a prodromal stage of parkinsonism. Neurodegenerative changes in the substantia nigra pars compacta (SNc) in parkinsonism can be detected using neuromelanin‐sensitive MRI.ObjectiveTo investigate SNc neuromelanin changes in iRBD patients using fully automatic segmentation.MethodsWe included 47 iRBD patients, 134 early Parkinson's disease (PD) patients and 55 healthy volunteers (HVs) scanned at 3 Tesla. SNc regions‐of‐interest were delineated automatically using convolutional neural network. SNc volumes, volumes corrected by total intracranial volume, signal‐to‐noise ratio (SNR) and contrast‐to‐noise ratio were computed. One‐way general linear models (GLM) analysis of covariance (ANCOVA) was conducted while adjusting for age and sex.ResultsAll SNc measurements differed significantly between the three groups (except SNR in iRBD). Changes in iRBD were intermediate between those in PD and HVs.ConclusionsUsing fully automated SNc segmentation method and neuromelanin‐sensitive imaging, iRBD patients showed neurodegenerative changes in the SNc at a lower level than in PD patients. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society