bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Argentine MistletoesLigaria cuneifolia(Ruiz & Pav.) Tiegh (Loranthaceae) andPhoradendron liga(Gillies ex Hook. & Arn.) Eichler (Santalaceae). Thirty Years of Research
Authors: Dobrecky Cecilia B. , Lucangioli Silvia E. , Wagner Marcelo L. 
Published: September 2022

AbstractLigaria cuneifolia(Ruiz & Pav.) Tiegh (Loranthaceae) andPhoradendron liga(Gillies ex Hook. & Arn.) Eichler (Santalaceae) are regarded as Argentine mistletoes based on their similarities with the European counterpart,Viscum albumL. (Santalaceae). These two species are the most used medicinal plants to treat high blood pressure in the Argentinian population. To provide scientific grounds to their traditional use and therapeutic potential, they were selected as herbal drug candidates. The main findings would support the anti‐hypertensive action, the anticholesterolemic and antioxidant features ofL. cuneifolia, and immunomodulatory properties for both species. Quercetin‐O‐glycosides, galloyl glycosides, and proanthocyanidins are present inL. cuneifoliawhileP. ligashows C‐glycosyl flavones and 3‐deoxyproanthocyanidins. This review summarizes the phytochemical characterization, medicinal properties and reveals promising results warranting future efforts for further investigation.
Caveolin‐1 suppresses hippocampal neuron apoptosis via the regulation of HIF1α in hypoxia in naked mole‐rats
Authors: Yang Wenjing , Wu Wenqing , Zhao Ying , Li Yu , Zhang Chengcai , Zhang Jingyuan , Chen Chao , Cui Shufang 
Published: September 2022

AbstractNaked mole‐rats (NMRs) (Heterocephalus glaber) are highly social and subterranean rodents with large communal colonies in burrows containing low oxygen levels. The inhibition of severe hypoxic conditions is of particular interest to this study. To understand the mechanisms that facilitate neuronal preservation during hypoxia, we investigated the proteins regulating hypoxia tolerance in NMR hippocampal neurons. Caveolin‐1 (Cav‐1), a transmembrane scaffolding protein, confers prosurvival signalling in the central nervous system. The present study aimed to investigate the role of Cav‐1 in hypoxia‐induced neuronal injury. Western blotting analysis and immunocytochemistry showed that Cav‐1 expression was significantly upregulated in NMR hippocampal neurons under 8% O2 conditions for 8 h. Cav‐1 alleviates apoptotic neuronal death from hypoxia. Downregulation of Cav‐1 by lentiviral vectors suggested damage to NMR hippocampal neurons under hypoxic conditions in vitro and in vivo. Overexpression of Cav‐1 by LV‐Cav‐1 enhanced hypoxic tolerance of NMR hippocampal neurons in vitro and in vivo. Mechanistically, the levels of hypoxia inducible factor‐1α (HIF‐1α) are also increased under hypoxic conditions. After inhibiting the binding of HIF‐1α to hypoxia response elements in the DNA by echinomycin, Cav‐1 levels were downregulated significantly. Furthermore, chromatin immunoprecipitation assays showed the direct role of HIF1α in regulating the expression levels of Cav‐1 in NMR hippocampal neurons under hypoxic conditions. These findings suggest that Cav‐1 plays a critical role in modulating the apoptosis of NMR hippocampal neurons and warrant further studies targeting Cav‐1 to treat hypoxia‐associated brain diseases.
Sirolimus‐coated balloon versus everolimus‐eluting stent in de novo coronary artery disease: Rationale and design of the TRANSFORM II randomized clinical trial
Authors: Greco Antonio , Sciahbasi Alessandro , Abizaid Alexandre , Mehran Roxana , Rigattieri Stefano , de la Torre Hernandez Jose M. , Alfonso Fernando , Cortese Bernardo 
Published: September 2022

AbstractBackgroundPercutaneous coronary intervention (PCI) with drug‐eluting stent (DES) implantation is a widely adopted strategy for the treatment of de novo coronary artery disease. DES implantation conveys an inherent risk for short‐ and long‐term complications, including in‐stent restenosis and stent thrombosis. Drug‐coated balloons are emerging as an alternative approach to fulfill the “leaving nothing behind” principle and avoid long‐term DES‐related complications.DesignTRANSFORM II is an investigator‐initiated, multicenter, noninferiority, randomized clinical trial, testing a sirolimus‐coated balloon (SCB) versus the standard of care for native coronary vessels with a 2–3 mm diameter, in terms of 12‐month target lesion failure (TLF; primary endpoint) and net adverse cardiovascular events (coprimary endpoint). Patients undergoing PCI will be randomized to be treated with either SCB or new‐generation everolimus‐eluting stent and will be followed up clinically for up to 60 months. Assuming a TLF rate of 8% at 12 months with DES, a sample size of 1325 patients was chosen to ensure an 80% power to detect a 1.5% lower incidence in the SCB group with a type I error rate of 0.05. The TRANSFORM II trial is registered on clinicaltrials.gov (identification number NCT04893291). Several substudies, including an optical coherence tomography assessment at 9 months (intracoronary imaging substudy), will investigate the study device in different clinical and lesion settings.ConclusionsThe randomized TRANSFORM II trial will determine whether a novel SCB is noninferior to a current everolimus‐eluting stent when adopted for the treatment of de novo lesions in coronary vessels with a diameter between 2 and 3 mm.
Harnessing the parallax for better spatial awareness
Authors: Targoński Radosław , Gąsecka Aleksandra , Luis Marlon S. , Jagielak Dariusz , Jaguszewski Miłosz , Piazza Nicolo 
Published: September 2022

AbstractDespite easy access to imaging diagnostic procedures and an abundance of spatial data, most cardiac interventions are still performed under two‐dimensional fluoroscopy. Incorporating anatomical data from scans into procedures plans has the potential to improve the swiftness and outcomes of percutaneous cardiac interventions. Therefore, procedure planning based on the specific anatomy is becoming a new standard of excellence in interventional cardiology. Still, we often tend to disregard specific spatial relations and the actual direction of catheter tip movement inside the body, relying on a try and error approach. The precise spatial orientation of instruments and prosthetic devices is crucial, especially during structural heart interventions. Here, we present how deliberate movements of objects under fluoroscopy can reveal the spatial orientation of catheters and other devices. We also propose a novel “two‐point rule” for identifying three‐dimensional relations between points in space. Understanding and applying this rule might substantially increase the spatial awareness of operators performing cardiovascular interventions. Although the concept is pretty simple, using it “live” during interventional cardiology procedures requires thorough understanding and practice. We propose the “two‐point rule” as a crucial rule to develop expertise in spatial orientation under fluoroscopy and ensure high‐quality outcomes.
Oxidation Behavior of Glassy Carbon in Acidic Electrolyte
Authors: Choudhury Sakeb Hasan , Ding Yuxiao , Yi Youngmi , Rohner Christian , Frandsen Wiebke , Lunkenbein Thomas , Greiner Mark , Schlögl Robert , Heumann Saskia 
Published: September 2022

AbstractGlassy carbon is frequently used in electrochemical research due to its presumed robust electrochemical performance. Although it is widely utilized as a rotating disc electrode material, the modification of glassy carbon during electro‐catalytic process is rarely emphasized or characterized. In this report, we investigated the structural modification of glassy carbon imparted by electrochemical oxidation in acidic media and compared the behavior with graphite. The functional groups generated from electrochemical oxidation in both electrodes possess similar electrochemical properties. However, above an oxidation potential of 1.8 V (vs. reversibly hydrogen electrode), glassy carbon exhibits a lower electrochemical capacitance compared to graphite. We propose that the existence of electrochemically inactive species, originating from the non‐graphitic portion of glassy carbon is attributed to such deterioration. Additionally, high resolution scanning electron microscopy (HR‐SEM) and high‐resolution transmission electron microscopy (HR‐TEM) images corroborate how electrochemical oxidation prevails for glassy carbon electrodes at oxidative potentials. The overall analysis leads us to propose a corrosion mechanism for glassy carbon in acidic solution.
The evaluation of planter downforce on emergence and grain yield in soybean
Authors: Soignier Tyler S. , Plumblee Michael T. , Mueller John D. , Greene Jeremy K. , Kirk Kendall R. 
Published: September 2022

AbstractPlanter downforce could unify crop emergence by maintaining uniform seeding depth while planting. This research was conducted to determine if planter downforce rate impacted soybean [Glycine max (L.) Merr.] emergence and grain yield in South Carolina. The effects of tillage type, gauge wheel width, and downforce rate (0–300 lbf in 50‐lbf increments) on soybean were evaluated at the Edisto (EREC) and Piedmont (PREC) Research and Education Centers in South Carolina. At EREC, a downforce rate over 200 lbf resulted in decreased plant emergence compared with 0, 50, 100, and 150 lbf. A downforce rate of 0 and 50 lbf had a reduced number of emerged plants at 2, 3, and 4 d after emergence compared with rates over 150 lbf at PREC. As downforce rate increased, the depth at which seed were planted increased up to 35% of the original planting depth at EREC. Planter downforce rate appears to influence overall soybean emergence. However, uniform emergence in soybean does not appear to impact grain yield in these production scenarios in South Carolina.
A Versatile Palladium Synthon: [Pd(NHC)(PhC≡CPh)]**
Authors: Bru Francis , Lesieur Mathieu , Poater Albert , Slawin Alexandra M. Z. , Cavallo Luigi , Cazin Catherine S. J. 
Published: September 2022

AbstractThe synthesis and isolation of [Pd(NHC)(PhC≡CPh)] complexes are reported. These new 14‐electron Pd(0)‐complexes are key synthons leading to known palladium(0) and palladium(II) species, as well as permitting access to unprecedented mixed NHC‐phosphite palladium(0) complexes. This motif permits the facile catalytic hydrosilylation of allenes. DFT calculations have allowed the characterization of the relatively weak interaction between the metal and the diphenylacetylene ligand, with a comparison with a series of ligands with more or less coordinating power, bearing varied structural and electronic properties.
One‐step Oxidative Monofluorination of Electron‐Deficient Sulfoxides to Access Highly Lewis Acidic Sulfur(VI) Cations
Authors: Berreur Jordan , Diez‐Varga Alberto , Manel Augustin , Leroux Frédéric R. , Panossian Armen 
Published: September 2022

AbstractThe strongly oxidizing, powerful electrophilic fluorination reagent [FXe][OTf] is shown to effect direct oxidative monofluorination of sulfoxides. This one‐step, chloride promoter‐free methodology provides access to so far inaccessible, yet highly desirable strongly Lewis acidic fluorosulfoxonium cations from electron‐deficient and/or sterically demanding sulfoxides that are shown to be practically unreactive towards the previously reported XeF2/NEt4Cl system. Experimental and density functional theory studies have been conducted to assess the Lewis acidities of the prepared sulfur(VI) cations. Preliminary results obtained with chiral sulfoxides provide early insights into the mechanism of these fluorination reactions.
Solids flux profiles of Geldart Group A particles in high‐velocity circulating fluidized bed risers
Authors: Issangya Allan S. , Karri S. B. Reddy , Cocco Ray A. , Knowlton Ted , Chew Jia Wei 
Published: September 2022

AbstractCirculating fluidized bed (CFB) risers using Group A particles have traditionally, mostly, been considered to operate in the fast fluidization regime, which consists of a core‐annulus flow profile with solids refluxing in the annulus layer. High gas and solids flow riser studies, however, suggest the existence of additional types of flow behaviours. Therefore, more studies are still needed to help clear uncertainties of local solids flow patterns in CFB risers of Group A particles, especially at gas and solids flow rates at or near those in commercial units. In this study, riser density and local solids flux profiles were measured in 0.3 m diameter risers of three CFB units at gas velocities of 9–16 m/s and solids fluxes of up to 700 kg/s · m2. A variety of radial solids flux profiles were obtained, including a parabolic profile with a peak flux at about the radial centre, a nearly flat profile across the riser cross‐section and an inverted parabola with peak upwards flux near the wall. At high gas velocity and solids flux, risers have no solids downflow at the wall. Multiple fluidization regimes were found to exist in the riser. The bottom dense part of the riser was in the dense suspension upflow regime, and the dilute upper part was in the dilute pneumatic transport regime. With commercial fluid catalytic cracking (FCC) risers operating at nearly similar conditions as tested here, it is likely that they also have one or both fluidization regimes and not the traditional fast fluidization regime. The data in this study fitted well on the Kim et al. fluidization regime map.
Rh(III)‐Catalyzed Enantioselective Intermolecular Aryl C—H Bond Addition to Aldehydes
Authors: Wu Zhi‐Jie , Wu Zhuo , Zhang Wen‐Wen , Gu Qing , You Shu‐Li 
Published: September 2022

Comprehensive SummaryThe direct addition of aryl C—H bond to carbon‐heteroatom double bond by transition‐metal‐catalyzed C—H activation has been extensively investigated in the past decade. However, the enantioselective intermolecular C—H addition to aldehyde has not yet been reported and is of significant challenge. Rh(III)‐catalyzed highly enantioselective intermolecular C—H addition of aryl oxime ethers to glyoxylates is reported. Chiral mandelic acid esters were obtained in excellent yields (up to 98%) and enantioselectivity (up to 99% ee) in the presence of a chiral CpRh(III) catalyst under mild conditions. The substituents on the Cp ring and BINOL skeleton were responsible for the high enantioselectivity observed. The method displays a broad substrate scope and good functionality tolerance. These results provide not only a promising C—H addition approach but also a proof of concept for developing broader asymmetric C—H addition reactions.
Synthesis and Biological Evaluation of Cardiac Glycosides for Cancer Therapy by Targeting the DNA Damage Response
Authors: Ainembabazi Diana , Geng Xinran , Gavande Navnath S. , Turchi John J. , Zhang Youwei 
Published: September 2022

AbstractCardiac glycosides (CGs) are bioactive compounds originally used to treat heart diseases, but recent studies have demonstrated their anticancer activity. We previously demonstrated that Antiaris toxicaria 2 (AT2) possesses anticancer activity in KRAS mutated lung cancers via impinging on the DNA damage response (DDR) pathway. Toward developing this class of molecules for cancer therapy, herein we report a multistep synthetic route utilizing k‐strophanthidin as the initial building block for determination of structure–activity relationships (SARs). A systematic structural design approach was applied that included modifications of the sugar moiety, the glycoside linker, stereochemistry, and lactone ring substitutions to generate a library of O‐glycosides and MeON‐neoglycosides derivatives. These molecules were screened for their anticancer activities and their impact on DDR signaling in KRAS mutant lung cancer cells. These results demonstrate the ability to chemically synthesize CG derivatives and define the SARs to optimize AT2 as a cancer therapeutic.
Enzyme‐Responsive Hydrogel for Delivery of the Anti‐Inflammatory Agent Zingerone
Authors: Sunnapu Omprakash , Khader Rajamohammed , Dhanka Mukesh , Kumar Vemula Praveen , Karuppannan Sekar 
Published: September 2022

AbstractInflammation highly fluctuates, and the level of inflammation varies in patients. Therefore, as opposed to conventional sustained release systems, delivering drugs in response to the inflammation and inflammation‐associated enzymes may have a beneficial effect in managing inflammatory diseases such as arthritis. Hence, we have developed an inflammation‐associated enzymes‐responsive hydrogel system. Zingerone is an active component in ginger and is known to exhibit a beneficial effect. We have studied the zingerone anti‐inflammatory properties using macrophages, and zingerone‐encapsulated self‐assembled hydrogels have been prepared and characterized in detail. Additionally, we have demonstrated that inflammation‐associated enzymes such as lipase could trigger the release of zingerone in a responsive manner, in vitro. In vivo efficacy of zingerone‐encapsulated hydrogel will be evaluated in preclinical models in the future.
Prenatal presentation of an adrenocortical tumor
Authors: Schwartz Jeffrey H. , Smith Erlyn 
Published: September 2022

AbstractBackgroundPrenatally identified suprarenal masses are most often found to be adrenal hemorrhage. The most common tumor in this situation is neuroblastoma.Case PresentationWe report the case of a rare adrenocortical tumor found prenatally on ultrasound. While most patients with adrenocortical tumors present with virilizing symptoms, our patient did not have evidence of virilization and was presumed to have neuroblastoma.ConclusionFollowing a period of observation, our patient underwent surgical resection due to tumor growth revealing the unexpected diagnosis.
Mesomeric Tuning at Planar Bi centres: Unexpected Dimerization and Benzyl C−H Activation in [CN2]Bi Complexes
Authors: Hynes Toren , Masuda Jason D. , Chitnis Saurabh S. 
Published: September 2022

AbstractPlanar bismuth(III) compounds featuring a N3‐pincer ligand environment are an unusual class of main group compounds that exhibit Lewis acidity via a 6p orbital. The ability to tune their acidity via Hammett and Coulomb effects has been demonstrated previously. Here we test the ability to tune them via mesomeric effects by replacing the central nitrogen of the [N3] pincer ligand with a less π‐donating carbon atom to achieve a [CN2] ligand environment. This strategy boosts the Lewis acidity at the metal to such an extent that only strongly‐bound dimers can be accessed in the condensed phase, or, if dimerization is sterically prohibited, an unusual reductive elimination occurs to give Bi(I) compounds. These results highlight the fine line separating donor/acceptor and redox chemistry at planar bismuth centres.
Excited‐State Intramolecular Charge‐Transfer Dynamics in 4‐Dimethylamino‐4′‐cyanodiphenylacetylene: An Ultrafast Raman Loss Spectroscopic Perspective
Authors: Barak Arvind , Dhiman Nishant , Sturm Floriane , Rauch Florian , Lakshmanna Yapamanu Adithya , Findlay Karen S. , Beeby Andrew , Marder Todd B. , Umapathy Siva 
Published: September 2022

AbstractPhoto‐initiated intramolecular charge transfer (ICT) processes play a pivotal role in the excited state reaction dynamics in donor‐bridge‐acceptor systems. The efficacy of such a process can be improved by modifying the extent of π‐conjugation, relative orientation/twists of the donor/acceptor entities and polarity of the environment. Herein, 4‐dimethylamino‐4′‐cyanodiphenylacetylene (DACN‐DPA), a typical donor‐π‐bridge‐acceptor system, was chosen to unravel the role of various internal coordinates that govern the extent of photo‐initiated ICT dynamics. Transient absorption (TA) spectra of DACN‐DPA in n‐hexane exhibit a lifetime of >2 ns indicating the formation of a triplet state while, in acetonitrile, a short time‐constant of ∼2 ps indicates the formation of charge transferred species. Ultrafast Raman loss spectroscopy (URLS) measurements show distinct temporal and spectral dynamics of Raman bands associated with C≡C and C=C stretching vibrations. The appearance of a new band at ∼1492 cm−1 in acetonitrile clearly indicates structural modification during the ultrafast ICT process. Furthermore, these observations are supported by TD‐DFT computations.
Ionic liquid‐based materials for electrochemical biosensing
Authors: Khorsandi Danial , Zarepour Atefeh , Rezazadeh Ilia , Ghomi Matineh , Ghanbari Roham , Zarrabi Ali , Esfahani Faranak Tarkesh , Mojahed Nooshin , Baghayeri Mehdi , Zare Ehsan Nazarzadeh , Makvandi Pooyan 
Published: September 2022

AbstractDue to their interesting features including negligible volatility, ease of designing in the construction, good chemical, and thermal stability, and excellent ionic conductivity, ionic liquids (ILs) have attracted a lot of attention to themselves in recent years. They are constructed from asymmetric anions and cations and are found in a liquid state lower than 100°C. Their unique features introduce them as candidates for the application in the structure of different types of electrochemical biosensors, in which they could act as electrolytes, or could be used as detecting agents. According to these features, this review aims to present an overview of the application of ILs in the structure of electrochemical sensors and biosensors. Based on this, after a brief description of the ILs and biosensors, the application of ILs in the structure of some of the recent electrochemical biosensors has been discussed and then, remarks and perspectives on these types of biosensors are explained.
Solasonine alleviates high glucose‐induced podocyte injury through increasing Nrf2‐medicated inhibition of NLRP3 activation
Authors: Zhang Qianjin , Hu Yichuan , Hu Jin‐E , Zhang Min 
Published: September 2022

AbstractThe worldwide high prevalence of diabetic nephropathy is one of the common causes of renal failure in diabetic patients. Hyperglycemia‐caused podocyte injury is considered as a major contributor to diabetic kidney disease, accompanied by a chronic inflammatory condition. Pyroptosis, a characterized inflammatory form of programmed cell death, is believed to be involved in the pathogenesis of diabetic nephropathy. Solasonine (SS) is a natural alkaloid and received attention as a potential anticancer agent. However, its protective effect against hyperglycemia‐caused podocyte injury remains to be determined. Our study found that SS alleviates cell apoptosis, and reduces pyroptosis and oxidative damage in high glucose (HG)‐treated MPC5 podocytes. Pro‐inflammatory cytokines, including interleukin (IL)‐1β and IL‐18, and caspase‐1 activity were markedly suppressed by SS in HG‐treated MPC5 podocytes. SS also reduced HG‐induced oxidative damage in MPC5 podocytes. Nrf2 expression was activated by SS in vitro under a HG condition. In addition, Nrf2 silencing attenuated the protective effect of SS against apoptosis, pro‐inflammatory cytokines release, caspase‐1 activity, and oxidative damage in MPC5 podocytes under a HG condition. Taken together, our findings revealed for the first time that SS alleviated high glucose‐induced podocyte apoptosis, pyroptosis, and oxidative damage via regulating the Nrf2/NLRP3 signaling pathway. Our results indicate that SS has the potential as a therapeutic agent for podocyte injury in diabetic nephropathy.