bluuebunny/crossref_metadata_2025_split huggingface dataset:
Superior Laryngeal Nerve Palsy After Anterior Cervical Diskectomy and Fusion: A Case Report and Cadaveric Description
Authors: Choy Winward , Garcia Joseph , Safaee Michael M. , Rubio Roberto R. , Loftus Patricia A. , Clark Aaron J. 
Published: July 2022

BACKGROUND AND IMPORTANCE:
Superior laryngeal nerve (SLN) injury after high cervical dissection can result in changes in vocal pitch due to cricothyroid denervation and dysphagia with aspiration risk because of decreased sensation of the supraglottic larynx.

CLINICAL PRESENTATION:
We describe a 69-year-old singer with cervical spondylotic myelopathy who underwent elective C3/4 and C4/5 anterior cervical diskectomy and fusion. Postoperatively, the patient reported changes in his voice, most noticeable with higher registers. A number of studies confirmed severe right superior laryngeal neuropathy. A cadaveric description included to highlight anatomic relationships critical in minimizing risk of SLN injury during an anterior cervical diskectomy and fusion approach.

CONCLUSION:
The SLN is a critical structure vulnerable to iatrogenic injury during high cervical dissections for anterior approaches to the spine. Therefore, it is critical for spine surgeons to have a firm understanding of SLN anatomy for these approaches.
CO2 Generation by Glucose and Derivatives Fuel Cells
Authors: Kaneto Keiichi , Uto Sadahito 
Published: July 2022

Abstract
Passive fuel cells using KOH solution of glucose and derivatives (sorbitol, gluconic, glucaric, glyoxylic and oxalic acids) substantially generated CO2. The composite of PEDOT:PSS, PtRu and SWCNT was used for the anode. CO2 volume vs released charge was evaluated after the measurement of discharge capacity. The glucose generated gaseous CO2 at 54 µL C−1. This agrees with the theoretical volume 63 µL C−1, namely, 6CO2 is effused by the 24-electron full oxidation.
Analysis of localisation of megakaryocytes in the bone marrow of the rat - possible relationship with innervations
Authors: Piątek Małgorzata , Polaniak Renata , Tabarowski Zbigniew , Staśkiewicz Wiktoria , Kiciak Agata , Grajek Mateusz 
Published: July 2022

Within the bone marrow, megakaryocytes thrive in an environment rich in numerous growth factors that influences their development, maturation, and may play a role in signaling the start of platelet production. Up to now, experiments concerning localisation of various populations of cells in rat bone marrow showed their certain relationship to the blood vessels. There are strikingly few reliable sources of information available in the literature that confirm the relationship between the localisation of these cells in connection to nerve fibers. Therefore the purpose of the present study was to examine if megakaryocytes are located in a defined relation to sensory and sympathetic nerve fibers.
The study used immature 6 weeks rats of the Wistar breed of both sexes. The animals were kept under constant lighting conditions (12 hours light-dark cycle) and temperature, and had unrestricted access to water and food (standard laboratory rodent feed).Double immunostaining method was applied with usage of secondary antibodies conjugated with fluorochromes (Cy3 and DTAF) to identify cells. The antibody against CD42d was used to immunolocalise megakaryocytes, while in order to identify the distribution of nerves, antibodies anti-NPY (for detection sympathetic nerve fibers) and anti-PGP 9.5 (sensory nerve fibers) were applied.
These findings showed the presence of megakaryocyte and megakaryoblastic cells which were distributed with a close relationship to the blood vessels but some of them were located in parenchyma. It was shown that NPY-positive and PGP 9.5-positive cells were present in the vicinity of blood cells. Furthermore, some megakaryocytes were located near PGP 9.5-labelled cells. The relationship between sympathetic nerve fibers containing neuropeptide Y and megakaryocytes was also detected.
Association of cytochromes P450 3A4*22 and 3A5*3 genotypes and polymorphism with response to simvastatin in hypercholesterolemia patients
Authors: Elalem Elbatool G. , Jelani Musharraf , Khedr Alaa , Ahmad Aftab , Alaama Tareef Y. , Alaama Mohamed Nabeel , Al-Kreathy Huda M. , Damanhouri Zoheir A. 
Published: July 2022

Backgrounds
Inter-individual variability in response to statin was mainly due to genetic differences. This study aimed to investigate the association of CYP3A4*22 (rs35599367), CYP3A5*3 (rs776746) single nucleotide polymorphism (SNP) with response to simvastatin in hypercholesterolemia patients conducted at King Abdulaziz University hospital (KAUH) in Jeddah, Saudi Arabia.

Patients and methods
A total of 274 participants were registered in the current study. Hypercholesterolemic patients taking simvastatin 20 mg (n = 148) and control subjects (n = 126) were tested for rs35599367 and rs776746 genotypes using Custom Taqman ® Assay Probes. Response to simvastatin in these patients was assessed by determination of low density lipoprotein (LDL-C), total cholesterol (TC) and by measuring statin plasma levels using Liquid Chromatography-Mass Spectrometry (LC-MS).

Results
None of the participants carried a homozygous CYP3A4*22 mutant genotype, while 12 (4.4%) individuals had a heterozygous genotype and 262 (95.6%) had a wild homozygous genotype. The CYP3A5*3 allele was detected in the homozygous mutant form in 16 (5.8%) individuals, while 74 (27.0%) individuals carried the heterozygous genotype and 184 (67.2%) carried the wildtype homozygous genotype. Of the patient group, 15 (11%) were classified as intermediate metabolizers (IMs) and 133 (89%) as extensive metabolizers (EMs). Plasma simvastatin concentrations for the combined CYP3A4/5 genotypes were significantly (P<0.05) higher in the IMs group than in the EMs group. TC and plasma LDL-C levels were also significantly (P<0.05) higher in IMs than in EMs.

Conclusion
The present study showed associations between CYP3A4*22 (rs35599367) and CYP3A5*3 (rs776746) SNP combination genotypes with response to statins in hypercholesterolemia. Patients who had either a mutant homozygous allele for CYP3A5*3 or mutant homozygous and heterozygous alleles for CYP3A4*22 showed increased response to lower TC and LDL-C levels.
Drivers of downloading and reasons for not downloading COVID-19 contact tracing and exposure notification apps: A national cross-sectional survey
Authors: Gao Golden , Lang Raynell , Oxoby Robert J. , Mourali Mehdi , Sheikh Hasan , Fullerton Madison M. , Tang Theresa , Manns Braden J. , Marshall Deborah A. , Hu Jia , Benham Jamie L. 
Published: July 2022

BackgroundBluetooth-enabled smartphone apps have been developed and implemented in different sites globally to help overcome capacity limitations of traditional interview-based COVID-19 contact tracing. Two apps are currently available in Canada: ABTraceTogether exclusively in Alberta and COVID Alert in nine other provinces and territories. This study aims to examine factors associated with downloading of these apps to inform targeted promotion and marketing to increase app uptake.MethodsWe performed a cross-sectional survey with adult participants (≥18 years old) from an online national panel. Participants were asked if they had downloaded an app and, if applicable, reasons for not downloading. Logistic regression was used to identify sociodemographic factors and trusted information sources associated with downloading and reasons for not downloading.ResultsOf the included 4,503 respondents (36% response rate), 1,394 (31%) had downloaded an app. Demographic and socioeconomic factors positively associated with app download were: 1) being female, 2) higher household income, 3) higher education level attained, and 4) more liberal political views. The odds of downloading an app were higher for participants who trusted health-related information sources, and lower for those who trusted internet searches, family and friend, or Facebook. The most cited reasons for not downloading were related to data security concerns and perceived lack of benefit from the apps.InterpretationThese findings identify sociodemographic segments with the lowest app uptake, reasons for not downloading and trusted information sources to inform targeted promotion and marketing strategies to improve uptake of apps to facilitate contact tracing.
Risk factors for HCV transmission in HIV-positive men who have sex with men in México
Authors: Mata-Marín José Antonio , de Pablos-Leal Armando Abraham , Mauss Stefan , Arroyo-Anduiza Carla Ileana , Rodríguez-Evaristo Mara Soraya , Uribe-Noguéz Luis Antonio , Berrospe-Silva María de los Ángeles , Lara-Castañeda Juan Carlos , Pérez-Barragán Edgar , Gaytán-Martínez Jesús 
Published: July 2022

Purpose
In the last two decades transmission of hepatitis C virus (HCV) in HIV positive men who have sex with men (MSM) has been reported globally. Chemsex and specific sexual practices have been identified as risk factors. Our study aimed to identify risk factors for HCV transmission in MSM living with HIV attending in Mexico.

Methods
We conducted a case-control study from April to December 2019 at the Hospital de Infectología “La Raza” National Medical Center, in Mexico City. A case was defined as an HIV-infected MSM with positive HCV-antibody test. For each case, 3 controls were included, defined as HIV infected MSM with negative HCV-antibody test. A self-questionnaire covering sexual practices and other risk factors for HCV transmission was applied. Bivariate analysis was performed to obtain odds ratio (OR) using Chi-square test. Independent risk factors were identified in a subsequent analysis performing a logistic regression model.

Results
A total of 324 patients participated in the study, 81 cases and 243 controls. Median age was 30.5 years (IQR: 18–52) and 28.8 years (IQR: 21–45) in the case and control group, respectively. Most prevalent HCV genotype was 1a (79%). In the logistic regression model, sharing straw during cocaine inhalation (OR: 9.03; 95% CI; 1.35–13.52; P = 0.003), sharing sex toys (OR: 17.53, 95% CI; 6.85–44.86; P = 0.002), and ethyl chloride use for chemsex (OR: 2.26; 95% CI; 1.29–5.56; P = 0.037) were significant risk factors for HCV infection.

Conclusion
This study identifies risk factors for HCV transmission in Mexico in HIV positive MSM in congruence with the findings of many studies performed worldwide. This is the first study that indicates a possible association between ethyl chloride use in chemsex and HCV infection. Assessment of local populations for risk factors for HCV transmission may help to develop specifically targeted behavioral interventions to reduce HCV transmission.
COVID-19 infection among vaccinated and unvaccinated: Does it make any difference?
Authors: Fatima Samar , Zafar Amara , Afzal Haris , Ejaz Taymmia , Shamim Sara , Saleemi Shayan , Subhan Butt Amna 
Published: July 2022

Objective
There is a probability that vaccination may lead to reduction in the severity and complications associated with COVID-19 infection among hospitalized patients. This study aimed to determine the characteristics, clinical profiles, and outcomes of COVID-19 infection in vaccinated and non-vaccinated patients.

Design and data sources
This prospective observational cohort study was conducted at the Aga Khan University Hospital (AKUH) and recruited COVID-19 patients admitted between June 1st and September 30th, 2021. Patients’ demographics, date of admission and discharge, comorbid conditions, immunization status for COVID-19 infection, presenting complaints, lab workup and computed tomography (CT) scan findings were obtained from the medical records. The primary outcome of the study was patients’ condition at discharge and the secondary outcomes included level of care, length of stay (LOS), requirement of non-invasive ventilation (NIV) and inotropic support.

Results
Among a cohort of 434 patients, 37.7% (n = 164), 6.6% (n = 29) and 55.5% (n = 241) were fully vaccinated, partially vaccinated, and unvaccinated, respectively. Around 3% and 42.9% of the patient required inotropic and NIV support respectively; however, there was no discernible difference between them in terms of vaccination status. In case of unvaccinated patients there were significantly increased number of critical care admissions (p-value 0.043). Unvaccinated patients had significantly higher median serum procalcitonin, ferritin, LDH and D-dimer levels. Around 5.3% (n = 23) of the patient required invasive ventilation and it was more common in unvaccinated patients (p-value 0.04). Overall, mortality rate was 12.2% (n = 53) and this was higher (16.2%, n = 39) in unvaccinated patients as compared to fully vaccinated patients (6.1%, n = 10, p-value 0.006).

Conclusions
Through this preliminary data, we can conclude that patient can develop severe and critical COVID-19 infection despite being vaccinated but this proportion is low as compared to unvaccinated population. So, uninterrupted endeavors need to be done to vaccinate as many individuals as possible. Furthermore, more effective vaccinations need to be developed to lessen the high death toll of COVID-19 infection.
Spatial distribution of health-risky road traffic noise pollution in Dessie City, North East Ethiopia
Authors: Bogale Getahun Gebre , Sisay Tadesse , Mekonen Asnakew Molla , Aemiro Muluken Tessema 
Published: July 2022

ObjectiveDessie is the trade center for northeast Ethiopia. High traffic flow plus overacting of promotion made the city noisy. There is a shortage of relevant evidence that enforces policy makers to design intervention plans. Therefore, this study aimed to explore the health-risky road traffic noise pollution in Dessie City, Ethiopia.MethodsThe study was conducted by purposive selection of the study area and sampling sites of the city from May 31, 2021 –June 6, 2021. Noise level recordings were taken by a digital Sound Meter and location data was collected by Global Positioning System. Residential, health facility, commercial, and mixed sites were identified by field observation. A total of 20 noise sampling points were included. The sampling points were selected by considering World Health Organization guideline. The measurements were taken twice a day at peak hours, between 8:00–11:00am and 4:00–7:00pm on all days of the week. The sound level meter was placed at a height of 1.5m and 2m from the curb. A total of 280 sound level records were conducted over one week.ResultsAmong twenty noise recording sites, more than 50% of them registered as excessive noisy sites for all types of site categories (health facility, residential, commercial, and mixed areas). For the seven days, average noise recordings were in the range of 66–72 dB at 83% of mixed areas; 33% of health facilities; 25% of residential areas, and 86% of commercial areas. The highest levels of noise pollution were seen at the Bus-station,BuanbuawuhaSquare,Tekuam,Arada, Ethio General Hospital,Ersha-seble, andMenafeshaareas.ConclusionThis study shows that the average noise level measurement within a week exceeded the permissible limits set by Ethiopia and the World Health Organization. It helps for policy development and timely actions against noise pollution and as baseline information for further investigation.
Definition and classification for adverse events following spinal and peripheral joint manipulation and mobilization: A scoping review
Authors: Funabashi Martha , Gorrell Lindsay M. , Pohlman Katherine A. , Bergna Andrea , Heneghan Nicola R. 
Published: July 2022

IntroductionSpinal and peripheral joint manipulation and mobilization are interventions used by many healthcare providers to manage musculoskeletal conditions. Although there are many reports of adverse events (or undesirable outcomes) following such interventions, there is no common definition for an adverse event or clarity on any severity classification. This impedes advances of patient safety initiatives and practice. This scoping review mapped the evidence of adverse event definitions and classification systems following spinal and peripheral joint manipulation and mobilization for musculoskeletal conditions in adults.MethodsAn electronic search of the following databases was performed from inception to February 2021: MEDLINE, EMBASE, CINAHL, Scopus, AMED, ICL, PEDro, Cochrane Library, Open Grey and Open Theses and Dissertations. Studies including adults (18 to 65 years old) with a musculoskeletal condition receiving spinal or peripheral joint manipulation or mobilization and providing an adverse event definition and/or classification were included. All study designs of peer-reviewed publications were considered. Data from included studies were charted using a standardized data extraction form and synthesised using narrative analysis.ResultsFrom 8248 identified studies, 98 were included in the final synthesis. A direct definition for an adverse event and/or classification system was provided in 69 studies, while 29 provided an indirect definition and/or classification system. The most common descriptors to define an adverse event were causality, symptom severity, onset and duration. Twenty-three studies that provided a classification system described only the end anchors (e.g., mild/minor and/or serious) of the classification while 26 described multiple categories (e.g., moderate, severe).ConclusionA vast array of terms, definition and classification systems were identified. There is no one common definition or classification for adverse events following spinal and peripheral joint manipulation and mobilization. Findings support the urgent need for consensus on the terms, definition and classification system for adverse events related to these interventions.
Health equity and wellbeing among older people’s caregivers in New Zealand during COVID-19: Protocol for a qualitative study
Authors: Burholt Vanessa , Balmer Deborah , Frey Rosemary , Meha Pare , Parsons John , Roberts Mary , Simpson Mary Louisa , Wiles Janine , Gregorzewski Moema , Percival Teuila , Reddy Rangimahora 
Published: July 2022

Background
Knowledge of the challenges unpaid caregivers faced providing care to older people during the COVID-19 pandemic is limited. Challenges may be especially pronounced for those experiencing inequitable access to health and social care. This participatory action research study, located in New Zealand, has four main objectives, (i) to understand the challenges and rewards associated with caregiving to older care recipients during the COVID-19 pandemic restrictions; (ii) to map and collate resources developed (or mobilised) by organisations during the pandemic; (iii) to co-produce policy recommendations, identify useful caregiver resources and practices, prioritise unmet needs (challenges); and, (iv) to use project results in knowledge translation, in order to improve caregivers access to resources, and raise the profile and recognition of caregivers contribution to society.

Methods and analysis
Māori, Pacific and rural-dwelling caregivers to 30 older care-recipients, and 30 representatives from organisations supporting caregivers in New Zealand will be interviewed. Combining data from the interviews and caregivers letters (from an archive of older people’s pandemic experiences), framework analysis will be used to examine the interrelated systems of the human ecological model and the impact on caregiving experiences during the pandemic. Resources that service providers had created or used for caregivers and older people will be collated and categorised. Through co-production with caregivers and community partners we will produce three short films describing caregivers’ pandemic experiences; identify a suite of resources for caregivers to use in future events requiring self-isolation, and in everyday life; and generate ideas to address unresolved issues.
Managing incontinence in low-and middle income-countries: A qualitative case study from Pakistan
Authors: Ansari Zara , White Sian 
Published: July 2022

Background
Incontinence is a complex health and social issue, which involves the involuntary loss of urine or faeces or both. Individuals with disabilities are particularly vulnerable to incontinence. The management of incontinence has largely been overlooked in low and middle-income settings (LMICs). This study aimed to explore the incontinence management strategies employed by disabled people with severe incontinence and their caregivers in Sindh Province, Pakistan.

Methods
Incontinence management was explored through in-depth interviews with people with incontinence (PWI) and their caregivers, photovoice, and a market survey and product attribute assessment. Data was analysed thematically through inductive coding and evaluated against existing disability and caregiver frameworks.

Results
Incontinence management affected all aspects of daily life for PWI and caregivers. Effective management of incontinence was prioritised because caregivers viewed it to be part of their familial duty and a requirement for the household to remain pure in the eyes of God. Coping strategies included strict adherence to routines, reducing food and drink intake, creative uses of locally available natural resources, and a heavy reliance on soap and water for maintaining hygiene. Products such as adult diapers were largely unavailable, costly and were not deemed suitable for regular use. There were no social or medical interventions in the region to support incontinence management. The main impacts of incontinence on the household were social isolation, stigma, role shifts within the family, the development of physical ailments among caregivers, and decreased income.

Conclusion
The complex health, psychological, social, economic, and cultural impacts of incontinence are exacerbated in LMICs due a lack of recognition of the condition, the absence of social or medical interventions and limited access to basic WASH infrastructure, and assistive devices or products. Appropriate solutions need to be developed in partnership with PWI and caregivers and need to be contextualised, affordable and sustainable.
Age impacts left atrial functional remodeling in athletes
Authors: Cousergue Cynthia , Saloux Eric , Reboursière Emmanuel , Rocamora Amélia , Milliez Paul , Normand Hervé , Hodzic Amir 
Published: July 2022

AimAge-associated changes in cardiac filling and function are well known in the general population. Yet, the effect of aging on left atrial (LA) function, and its interaction with left ventricular (LV) adaptation, remain less described when combined with high-intensity chronic training. We aimed to analyze the effects of aging on LA and LV functions in trained athletes.Methods and resultsNinety-five healthy highly-trained athletes referred for resting echocardiography were included. Two groups of athletes were retrospectively defined based on age: young athletes aged <35 years (n = 54), and master athletes aged ≥35 years (n = 41). All subjects were questioned about their sports practice. Echocardiographic analysis of LV systolic and diastolic functions (2D-echo, 3D-echo, and Doppler), as well as LA 2D dimensions and phasic deformations assessed by speckle tracking, were analyzed. Master athletes (mean age = 46.3 ± 8.3 years, mean duration of sustained training = 13.7 ± 8.9 years) exhibited significantly stiffer LV and LA with reduced LV early diastolic functional parameters (ratio E/A, peak e’, and ratio e’/a’), LA reservoir and conduit strain, whereas LA volume, LA contractile strain and LV peak a’ were higher, compared to young athletes. Multivariate regression analysis confirmed that age was predictive of peak e’, LA reservoir strain and LA conduit strain, independently of training variables. LA phasic strains were strongly associated with LV diastolic function.ConclusionsRegardless of chronic sports practice, master athletes exhibited age-related changes in LA function closely coupled to LV diastolic properties, which led to LV filling shifts to late diastole.
Hegemonic Mimicry: Korean Popular Culture of the Twenty-First Century, Kyung Hyun Kim (2021)
Authors: Hyland Robert 
Published: July 2022

Review of: Hegemonic Mimicry: Korean Popular Culture of the Twenty-First Century, Kyung Hyun Kim (2021)
Durham and London: Duke University Press, 328 pp.,
ISBN 978-1-47801-449-2, p/bk, $27.95 and e-book, $15.37