bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of Bladder Cancer in Dr. Sardjito General Hospital Yogyakarta: a 5-Year Report
Authors: Prisnamurti Fitra Hardian , Hendri Ahmad Zulfan , Danurdoro Aria 
Published: April 2022

Background: Bladder cancer is the eleventh most common malignancy worldwide and the sixth cancer in men. Bladder cancer shows a male predominance with a sex ratio of 4:1. Most bladder cancers are transitional cell carcinoma, and the other tumors are squamous cell carcinoma, adenocarcinoma, and rare entities like small cell carcinoma. Clinical stage and grade are the most critical determinants of the prognosis of bladder cancer. Therefore, this study aims to evaluate the characteristics of bladder cancer in Dr. Sardjito General Hospital, Indonesia. Methods: We reviewed the medical records of patients with bladder cancer admitted to Dr. Sardjito General Hospital Yogyakarta from January 2015 until December 2020. The data were about demographic characteristics, clinical presentation and staging, grading and staging based on pathological examinations results, and cancer management. Results: This study found 282 patients with bladder tumors. Fifty patients did not meet the inclusion criteria so the remaining 232 patients consisted of 169 male patients (72.8%) and 62 female patients (27.2%). The stages of tumors when the patients first came in were T1 diagnosed in 46 patients (22.7%), T2 diagnosed in 81 patients (40%), T3 diagnosed in 11 patients (5.4%), and T4 diagnosed in 64 patients (31.6%). A total of 30 patients were found to have secondary bladder tumors. The pathological anatomy results showed that 177 patients (76.2%) had transitional cell carcinoma and 33 patients adenocarcinoma (14.2%). All patients had undergone Transurethral Resection of Bladder Tumor (TURBT) for diagnosis and staging, followed by definitive treatment. It consisted of TURBT and chemotherapy bladder instillation in 46 patients (19.8%), radical cystectomy in 84 patients (36.2%), partial cystectomy in 4 patients (1.7%), and multimodal therapy (en-bloc transurethral resection of bladder tumors (ERBT) and chemotherapy) in 26 patients (11.2%). There were 72 patients (31%) who underwent TURBT alone. Conclusions: From a 5-year study, we found similar results with previous studies that the most common bladder histopathological result is urothelial carcinoma. However, most patients presenting to our hospital have higher stages and grades, requiring radical treatment. These differences warrant a larger and more comprehensive, multi-center study in Indonesia.
The Profile of Soft Tissue Sarcoma Patients who Undergo Radiotherapy in Dr. Hasan Sadikin General Hospital Bandung
Authors: Adibrata Antony Abel , Utama Marhendra Satria , Kusumadjati Adji 
Published: April 2022

Background: Soft Tissue Sarcoma is one of the rare cancers that increased in number in the last few years, but information about soft tissue sarcoma patients was still limited, especially in West Java, Indonesia. This study aimed to find out the patient profile and the histopathological cell distribution of soft tissue sarcoma patients who undergo radiotherapy. Methods: The study design was retrospective descriptive quantitative with the total sampling method. This study was done by observing all patients’ medical records registered from January 1, 2018, until December 31, 2019, in the Hospital-Based Cancer Registry of Radiology Department of Dr. Hasan Sadikin General Hospital Bandung, with the inclusion criterion of patients diagnosed with soft tissue sarcoma. Results: A total of 5% (n = 75) from 1,388 cases registered were soft tissue sarcoma. The most common patient profile was female (57.3%) and age group 45–54 years (21.3%). The chief complaint was dominated by a painless mass (56.0%) at the lower limb (37.8%) with the most frequent cell of fibrosarcoma (17.3%), the most intention of the radiotherapy of curative adjuvant (78.7%). Conclusions: The number of soft tissue sarcoma is small compared to other malignancies. It is more common in women, the most age group is from 45 to 54 years with the median of 47 years old, ranging from 9 to 90 years, it tends to occur in the lower limb with a chief complaint of a painless mass, and the most frequent cell is fibrosarcoma. The common treatment combination is surgery with radiotherapy
Diagnóstico e manejo da xerostomia em pacientes com COVID-19
Authors: Ferreira Gerson Luís Castro , Gomes Ana Viviam Souza Ferro , Sousa Ana Clarade Carvalho , Lopes Estefany Monteiro , Viegas Raissa de Oliveira , França Allana Alexia Mendes Dos Santos da , Castro Francisca Ângela Sousa , Carvalho Romayla de Andrade , Fontenele Maria Éryka Giovanna de Brito , Fortaleza Vitória Gindri 
Published: April 2022

A xerostomia ou boca seca é uma alteração encontrada rotineiramente na prática clínica odontológica, esta alteração afeta diretamente a qualidade de vida do paciente, manifestando dificuldades na degustação, mastigação, fala, deglutição e causa muito desconforto na cavidade oral. Contudo, após o início da pandemia da COVID-19, foi notado pelos pesquisadores uma grande queixa de pacientes infectados relatando a sensação de boca seca. Este estudo tem como objetivo principal avaliar a forma que a xerostomia acomete os pacientes com COVID-19. O estudo foi realizado por meio de uma revisão de literatura, pesquisando os artigos do Google Acadêmico, PubMed, e SciELO utilizando os descritores: “Oral Manifestations”; “Xerostomia” e “COVID-19”. Todos os artigos foram selecionados por ano, título, resumo, texto completo e, por fim, todos os artigos selecionados foram processados para revisão final. 20 artigos selecionados foram obtidos a partir da pesquisa bibliográfica inicial de 295 artigos, relatos obtidos a partir dos estudos selecionados demonstram que a xerostomia possui alta incidência em pacientes que foram infectados pela COVID-19, o que impacta diretamente na qualidade de vida deles e na forma que reagem aos tratamentos quando são submetidos à tratamentos hospitalares, contudo, outras manifestações orais aparecem fortemente, o que causa uma maior debilitação na saúde sistêmica do paciente. As manifestações bucais, como xerostomia, intercorrências no paladar, inflamação das glândulas salivares, devidamente citadas no estudo, são tipicamente relatadas em pacientes que apresentaram infecção viral pelo Sars-CoV-2, e cabe ressaltar que, independentemente da patogenia dessas manifestações, denota-se a importância do desenvolvimento de protocolos específicos.
Antitumor and antileishmanial activities of limonene-thiosemicarbazones bearing heterocycles nucleous
Authors: Vandresen Fabio , Almeida-Batista Sabrina Alencar de , Caldeira Maria Eduarda Bueno , Romeral Richard de Albuquerque Felizola , Nakamura Celso Vataru , Ruiz Ana Lucia Tasca Góes , Silva Cleuza Conceição da 
Published: April 2022

In the present study, we provided the synthesis of a series of R-(+)- and S-(-)-limonene-based thiosemicarbazones containing different pentacyclic heterocyclic nucleus moiety focused in the search of novel antitumor and antileishmanial agents. In the antitumor assay, the derivative imidazole of S-(-)-limonene 8 was the most active compound, especially for U-251, UACC-62 and K562 human tumor cell lines with GI50 ranging from 1.0 to <0.25 µg.mL-1. On the other hand, the imidazole-thiosemicarbazone of R-(+)-limonene 4 was the most promising derivative against the promastigote form of L. amazonensis (IC50=5.9µM). Meanwhile, thiosemicarbazones without limonene moiety (9-12) showed the lowest activities in the biological assays performed. The results demonstrated the influence of the lipophilic molecular character and stereochemistry of chiral monoterpene on the evaluated activities.
Identification of Peripheral Anterior Synechia by Corneal Deformation Using Air-Puff Dynamic Anterior Segment Optical Coherence Tomography
Authors: Ye Shuling , Bao Chenhong , Chen Yulei , Shen Meixiao , Lu Fan , Zhang Shaodan , Zhu Dexi 
Published: April 2022

Indentation gonioscopy is commonly used in the clinic to evaluate peripheral anterior synechia (PAS) of angle closure glaucoma (ACG). The examination requires contacting with the cornea, resulting in an uncomfortable feeling for patients, and it only provides qualitative outcomes which may be affected by subjective judgment of the clinicians. Previous studies had reported to identify the presence of PAS by measuring the changes of morphological parameters of the anterior chamber angle (ACA) under the pupillary light reflex, by anterior segment optical coherence tomography (AS-OCT). However, this method was invalid for some subjects who had low sensitiveness to light. This article describes an air-puff dynamic anterior segment optical coherence tomography (DAS-OCT) system that can evaluate the presence of PAS in a non-contact approach. The peripheral cornea is deformed by an air puff jetted from the DAS-OCT, causing a transfer of force to the ACA, just as how indentation gonioscopy works. The dynamic changes of the ACA before and after the air puff are recorded by OCT. Ten eyes of normal subjects were enrolled in this study to validate the repeatability and availability of the measurements. Then, ten samples of the ACA from five subjects with ACG were recruited and were assigned into two groups, the non PAS group (NPAS) and PAS group, according to the results of gonioscopy. The ACA structural parameters including the angle opening distance at 750 μm to the scleral spur (AOD750) and the trabecular-iris space area at 750 μm anterior to the scleral spur (TISA750) were then calculated automatically by a custom-written algorithm. The intraclass correlation coefficient (ICC) of measured parameters was all above 0.85 for normal subjects, exhibiting good repeatability. For patients, both parameters showed significant differences between the two groups after the air puff, while no differences were observed before the air puff. AOD750dif and TISA750dif between two groups showed more significant differences, indicating that they could be used as indicators to identify the presence of PAS. In conclusion, the DAS-OCT system proposed in this study is demonstrated effective to identify the presence of PAS by measuring the changes of the ACA via a noncontact approach. It shows great potential for applications in guidance for diagnosis of angle closure glaucoma.
Type 1 T Helper Cell-Based Molecular Subtypes and Signature Are Associated with Clinical Outcome in Pancreatic Ductal Adenocarcinoma
Authors: Wei Ran , Zhang Huihui , Cao Jianzhong , Qin Dailei , Deng Wuguo , Li Shengping 
Published: April 2022

Lymph node metastasis in pancreatic ductal adenocarcinoma (PDAC) is shown to be related with poor prognosis. To construct an immune-related gene prognostic risk model for PDAC and clarify the molecular and immune characteristics and the benefit of immune checkpoint inhibitor (ICI) therapy in prognostic risk model-defined subgroups of PDAC, we analyze the association between the density of immune cell infiltration and lymph node metastatic status and further study the potential role of immune cells, immune cell–related genes, and immunotherapy outcomes in PDAC patients using bioinformatics models and machine learning methods. Based on The Cancer Genome Atlas (TCGA), PACA-AU and PACA-CA data sets, 62 immune-related hub genes were identified by weighted gene co-expression network analysis (WGCNA). Four genes were selected to construct a molecular subtype identification based on the type 1 T helper cell–related hub genes by using the Cox regression method. We found that lower type 1 T helper cell abundance was correlated with prolonged survival in PDAC patients. Further, prognostic risk score model constructed with the type 1 T helper cell-related signature showed high accuracy in predicting overall survival and response to immunotherapy. This study might improve the understanding of the role of type 1 T helper cells in PDAC patients and aid in the development of immunotherapy and personalized treatments for these patients.
Relief of Phosphate Limitation Stimulates Methane Oxidation
Authors: Nijman Thomas P. A. , Amado André M. , Bodelier Paul L. E. , Veraart Annelies J. 
Published: April 2022

Aquatic ecosystems such as shallow lakes and wetlands are important emitters of the greenhouse gas methane (CH4). Increased phosphorus (P) loading is expected to increase CH4production in these ecosystems. This increased CH4production can potentially be mitigated by increased CH4oxidation, but how P availability affects methane-oxidizing bacterial (MOB) community composition and potential CH4oxidation remains to be tested. Here, we incubated MOB from sediments of four subtropical lakes of different trophic states for 7 days at different phosphate (PO43-) concentrations to determine the effects of P on MOB community composition and potential CH4oxidation. We measured CH4consumption daily and compared CH4oxidation during the exponential growth phase. Furthermore, we determined MOB community composition at the end of the incubations using qPCR of thepmoAgene. To test for differences in N and P uptake, we determined bacterial biomass N and P content. We found that increases in PO43-concentrations until 10 µM significantly increased CH4oxidation. PO43-also increased bacterial biomass P content, while N content was not affected. MOB community composition was not affected by PO43-but more strongly correlated to lake of origin, likely due to the short duration of the incubations. Our results show that PO43-can not only stimulate CH4oxidation indirectly through increased CH4production, but also directly by increasing MOB growth. Importantly, these effects only occur at low PO43-concentrations, indicating that at high nutrient loads the increased CH4oxidation will likely not mitigate the increased CH4production.
Patterns of Peripheral Blood B-Cell Subtypes Are Associated With Treatment Response in Patients Treated With Immune Checkpoint Inhibitors: A Prospective Longitudinal Pan-Cancer Study
Authors: Barth Dominik A. , Stanzer Stefanie , Spiegelberg Jasmin A. , Bauernhofer Thomas , Absenger Gudrun , Szkandera Joanna , Gerger Armin , Smolle Maria A. , Hutterer Georg C. , Ahyai Sascha A. , Madl Tobias , Posch Florian , Riedl Jakob M. , Klec Christiane , Jost Philipp J. , Kargl Julia , Stradner Martin H. , Pichler Martin 
Published: April 2022

BackgroundImmune checkpoint inhibitors (ICIs) have revolutionized systemic anti-tumor treatments across different types of cancer. Nevertheless, predictive biomarkers regarding treatment response are not routinely established yet. Apart from T-lymphocytes, the humoral immunity of B-lymphocytes is studied to a substantially lesser extent in the respective setting. Thus, the aim of this study was to evaluate peripheral blood B-cell subtypes as potential predictors of ICI treatment response.MethodsThirty-nine cancer patients receiving ICI therapy were included into this prospective single-center cohort study. All had a first blood draw at the date before treatment initiation and a second at the time of first response evaluation (after 8-12 weeks). Seven different B-cell subtypes were quantified by fluorescence-activated cell sorting (FACS). Disease control- (DCR) and objective response rate (ORR) were co-primary study endpoints.ResultsOverall, DCR was 48.7% and ORR was 25.6%, respectively. At baseline, there was no significant association of any B-cell subtype with neither DCR nor ORR. At the first response evaluation, an increase in the frequency of CD21- B-cells was a statistically significant negative predictor of response, both regarding DCR (OR=0.05, 95%CI=0.00-0.67, p=0.024) and ORR (OR=0.09, 95%CI=0.01-0.96, p=0.046). An increase of the frequency of switched memory B-cells was significantly associated with reduced odds for DCR (OR=0.06, 95%CI=0.01-0.70, p=0.025). Patients with an increased frequency of naïve B-cells were more likely to benefit from ICI therapy as indicated by an improved DCR (OR=12.31, 95%CI=1.13-134.22, p=0.039).ConclusionIn this study, certain B-cell subpopulations were associated with ICI treatment response in various human cancer types.
CuO-GO-Ag; Green Synthesis With Fagonia Arabica and Biomedical Potential is a Bioinspired Nano Theranostics Composite
Authors: Shahid Sammia , Mansoor Sana , Javed Mohsin , Iqbal Shahid , Yousaf Umair , Alsaab Hashem O. , Awwad Nasser S. , Ibrahium Hala A. , Alzhrani Rami M. , Alqahtani Mashael D. , Tamam Nissren , Elkaeed Eslam B. , Zaman Sabah , Sarwar Muhammad Nazim , Riaz Tauheeda 
Published: April 2022

In this study, a green synthesis strategy was used to construct CuO-GO-Ag nanocomposites (NCs) by using biological components of Fagonia arabica. Copper Oxide (CuO) nanoparticles and silver (Ag) nanoparticles were fabricated by using a plant extract of Fagonia arabica. Graphene oxide was synthesized by hummer’s method and hydrothermal approach. The characterization techniques used in this work were Energy Dispersive X-ray (EDX), Scanning electron microscopy (SEM), X-ray Diffraction (XRD), and ultra-violet visible spectroscopy (UV-Vis). As an innovative approach graphene oxide (GO) was firstly assorted with green synthesized CuO NPs and then Ag nanoparticles were incorporated to form amalgamated CuO-GO-Ag nanocomposite (NCs). The anti-inflammatory and antioxidant activity of nanocomposite were examined. The anti-inflammatory and antioxidant ability of the nanocomposite were evaluated by UV-Visible spectroscopy. Results reveal that biologically synthesized CuO-GO-Ag NCs have high scavenging and inflammation reduction potential as compared to standards (ascorbic acid, diclofenac sodium). CuO-GO-Ag showed that scavenging efficiency for 0.3 mg/ml is 57.40% and for 0.5 mg/ml is 74.24% while scavenging efficiency for standard (ascorbic acid) is 44.22% for 0.3 mg/ml and 58.42% for 0.5 mg/ml. Likewise, CuO-GO-Ag nanocomposite showed a % inhibition value of 46.59 and 87.80 at 0.1 mg/ml and 0.5 mg/ml while diclofenac sodium showed a % inhibition value of 10.98 and 35.37 a similar concentration. Fagonia arabica seems to be a good source for acclimating the potential of NCs and nanoparticles toward different increased biological activities, according to the findings.
High-Throughput CALPHAD: A Powerful Tool Towards Accelerated Metallurgy
Authors: Ghassemali Ehsan , Conway Patrick L. J. 
Published: April 2022

Introduction of high entropy alloys or multi-principal element alloys around 15 years ago motivated revising conventional alloy design strategies and proposed new ways for alloy development. Despite significant research since then, the potential for new material discoveries using the MPEA concept has hardly been scratched. Given the number of available elements and the vastness of possible composition combinations, an unlimited number of alloys are waiting to be investigated! Discovering novel high-performance materials can be like finding a needle in a haystack, which demands an enormous amount of time and computational capacity. To overcome the challenge, a systematic approach is essential to meet the growing demand for developing novel high-performance or multifunctional materials. This article aims to briefly review the challenges, recent progress and gaps, and future outlook in accelerated alloy development, with a specific focus on computational high-throughput (HT) screening methods integrated with the Calculation of Phase Diagrams (CALPHAD) technique.
Development of a Machine Learning-Based Predictive Model for Lung Metastasis in Patients With Ewing Sarcoma
Authors: Li Wenle , Hong Tao , Liu Wencai , Dong Shengtao , Wang Haosheng , Tang Zhi-Ri , Li Wanying , Wang Bing , Hu Zhaohui , Liu Qiang , Qin Yong , Yin Chengliang 
Published: April 2022

BackgroundThis study aimed to develop and validate machine learning (ML)-based prediction models for lung metastasis (LM) in patients with Ewing sarcoma (ES), and to deploy the best model as an open access web tool.MethodsWe retrospectively analyzed data from the Surveillance Epidemiology and End Results (SEER) Database from 2010 to 2016 and from four medical institutions to develop and validate predictive models for LM in patients with ES. Patient data from the SEER database was used as the training group (n = 929). Using demographic and clinicopathologic variables six ML-based models for predicting LM were developed, and internally validated using 10-fold cross validation. All ML-based models were subsequently externally validated using multiple data from four medical institutions (the validation group, n = 51). The predictive power of the models was evaluated by the area under receiver operating characteristic curve (AUC). The best-performing model was used to produce an online tool for use by clinicians to identify ES patients at risk from lung metastasis, to improve decision making and optimize individual treatment.ResultsThe study cohort consisted of 929 patients from the SEER database and 51 patients from multiple medical centers, a total of 980 ES patients. Of these, 175 (18.8%) had lung metastasis. Multivariate logistic regression analysis was performed with survival time, T-stage, N-stage, surgery, and bone metastasis providing the independent predictive factors of LM. The AUC value of six predictive models ranged from 0.585 to 0.705. The Random Forest (RF) model (AUC = 0.705) using 4 variables was identified as the best predictive model of LM in ES patients and was employed to construct an online tool to assist clinicians in optimizing patient treatment. (https://share.streamlit.io/liuwencai123/es_lm/main/es_lm.py).ConclusionsMachine learning were found to have utility for predicting LM in patients with Ewing sarcoma, and the RF model gave the best performance. The accessibility of the predictive model as a web-based tool offers clear opportunities for improving the personalized treatment of patients with ES.
Circulating Trimethylamine-N-Oxide and Risk of All-Cause and Cardiovascular Mortality in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis
Authors: Zhou Zhongwei , Jin Hao , Ju Huixiang , Sun Mingzhong , Chen Hongmei , Li Li 
Published: April 2022

BackgroundTrimethylamine-N-oxide (TMAO) is expected to be a prognostic biomarker among patients suffering from chronic kidney disease (CKD). However, investigations on the association between TMAO and CKD prognosis are conflicting. In the present article, we aimed to assess the relationship of circulating TMAO with the risk of all-cause and cardiovascular mortality among CKD patients by a meta-analysis.MethodsData were collected from PubMed, EMBASE, and Web of Science for systematically searching related literature (last update: February 2022). The multivariable-adjusted hazard risks (HR) and their 95% confidence intervals (CI) were pooled using random effects models.ResultsEleven prospective cohort studies covering 7,899 CKD patients were enrolled in this meta-analysis. When comparing individuals in the top and bottom baseline TMAO levels thirds, the multivariate adjusted pooled HR was 1.29 (95% CI 1.11–1.51, P = 0.001) for all-cause mortality, and 1.45 (95% CI 1.01–2.09, P = 0.043) for cardiovascular death. For continuous variables, per 1 unit increase of circulating TMAO levels was associated with a 3% higher all-cause mortality (HR 1.03, 95% CI 1.00–1.06, P = 0.032), but not significantly associated with cardiovascular death (HR 1.08, 95% CI 0.92–1.27, P = 0.346). Stratified analyses revealed that the positive relationship between TMAO and all-cause mortality remained significant after adjusting for diabetes, blood pressure, blood lipid, renal function, or inflammatory parameters.ConclusionHigher circulating TMAO was associated with an increased mortality risk among patients with CKD, and this relationship may be dependent on TMAO dose and independent of renal function, inflammation, diabetes, hypertension, and dyslipidemia.Systematic Review Registration[https://www.INPLASY.COM], identifier [INPLASY2021100049].