bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sistem Pendukung Keputusan Kelayakan Pinjaman Kredit Berbasis Web (Di PT. FIF Group Cabang Surabaya)
Authors: Wicaksono Wahyu , Brastama Putra Agung , Agussalim  
Published: June 2022

Peningkatan dikalangan masyarakat dalam kegiatan pengajuan kredit, yang perlu adanya keseimbangan fasilitas kredit pada masyarakat. PT.FIFGROUP Kantor Cabang Surabaya adalah salah satu lembaga jasa pembiayaan yang berada di Kota Surabaya. PT Federal Internasional Finance Group yaitu perusahaan yang bergerak di bidang jasa pembiayaan kredit yang didirikan pada tahun 1989 oleh PT Astra International Tbk. serta mendirikan fasiitas pembiayaan konvensional dan syariah pada tahun 1991. Dalam menentukan pinjaman kredit PT.FIFGROUP akan melakukan persetujuan dan dipertimbangkan pinjaman kredit tersebut untuk nasabah dari Head Office. Selanjutnya akan dilakukan tahap pengecekkan data 1 sampai 2 hari kerja, setelah pengecekkan data selesai akan dilakukan persetujuan Manager Office dan Branch Manager. Dalam analisis dan menetukan pengambilan keputusan nasabah pada PT .FIFGROUP juga ditemukan menggunakan sistem yang masih manual yang akan menguras waktu yang lam, yang akan membuat nasabah menunggu lama untuk dilakukan pencairan pinjaman kredit tersebut. Serta perhitungan pinjaman nasabah masih menggunakan microsoft excel dan upload data yang telah disetujui juga masih menggunakan manual.Kekurangan dari sistem peminjaman dengan menggunakan microsoft excel akan terjadi kesalahan dalam perhitungan, serta tidak disimpan data perolehan pinjaman nasabah, angsuran dan tahun kendaraan. Serta komputer yang tidak bisa menampung data terlalu banyak dari microsoft excel. Maka dibutuhkan sebuah sistem terkomputerisasi yang berguna untuk meminimalisir adanya kelebihan data pada komputer, adanya kesalahan yang sering terjadi pada nasabah dan menentukan keputusan yang akan diambil.Pengembangan Sistem Informasi Kelayakan Pinjaman kredit berbasis Web dengan metode SAW di PT.FIFGROUP Cabang Surabaya, dibangun berbasis PHP dengan menggunakan metode SAW. Pada tahap berikut ini akan dilakukan analisis kebutuhan, pembuatan desain pada sistem, tahap implementasi, selanjutnya dilakukan tahap uji coba, tahap dokumentasi laporan dan pengujian sebuah sistem menggunakan blackbox. Kesimpulan pada tahap ini sistem akan dapat memahami penentuan nasbah dalam pinjaman kredit dan metode perhitungan dalam pinjaman nasabah sesuai dengan yang ditetapkan PT.FIFGROUP Cabang Surabaya serta memilki fitur hasil laporan nasabah.
Sistem Pendukung Keputusan Rekomendasi Lokasi ATM Menggunakan Metode Fuzzy Electre
Authors: Yahya Mahendra Rizqi , Nugroho Budi , Mustika Rizki Agung 
Published: June 2022

Proses perbankan digital atau e-banking sudah marak diimplementasikan oleh banyak perusahaan perbankan untuk meningkatkan efisiensi proses transaksi yang dilakukan oleh nasabah tanpa harus menuju ke kantor bank terdekat. Pada salah satu bank milik pemerintah Indonesia memiliki departemen E-Channel Operation yang bertanggung jawab atas pengelolaan dan pemeliharaan komponen e-banking salah satunya adalah ATM (Automated Teller Machine). Terdapat permasalahan yang dihadapi dengan belum terujinya akurasi dari metode rekomendasi lokasi ATM eksisting yang dapat mengakibatkan kerugian biaya dikarenakan kurang tepatnya penempatan lokasi dari ATM yang kurang strategis atau susah dijangkau nasabah. Belum adanya sistem yang dapat menangani masalah tersebut menjadi tujuan penelitian ini dilakukan dengan membangun sistem pendukung keputusan rekomendasi penempatan lokasi ATM. Metode yang akan digunakan untuk fitur tersebut adalah metode Fuzzy ELECTRE. Diyakini metode ini ampuh dalam melakukan perankingan berdasarkan pada hubungan outranking dan menggunakan indeks kesesuaian dan ketidaksesuaian untuk menganalisa hubungan antar alternatif. Dari hasil perbandingan metode yang digunakan dengan metode eksisting yakni AHP-WASPAS, didapatkan akurasi perbandingan 100% dengan kesamaan hasil kluster yakni 10 data direkomendasikan dan 10 data tidak direkomendasikan dengan catatan masih terdapat beberapa perbedaan urutan ranking dari dua metode. Pengujian ulang dengan percobaan pengubahan nilai TFN juga tidak mempengaruhi hasil ranking. Dengan dibuatnya sistem ini, proses bisnis pengembangan komponen e-banking oleh departemen e-channel opearation dapat berjalan dengan maksimal.
Simulasi Fog Computing Pada Skenario Smart Home Menggunakan Ifogsim
Authors: Agussalim Agussalim 
Published: June 2022

Cloud server bertugas mengumpulkan dan memproses data yang dikirimkan dari setiap perangkat IoT, kemudian melakukan eksekusi dan mengirimkan Kembali informasi yang telah diolah secara visual (proses ini disebut sebagai aktuasi). Permasalahan muncul Ketika lokasi dari cloud server jauh dari sumber data IoT, sehingga dibutuhkan komunikasi multi-hop dari sumber data IoT menuju Cloud Server. Fog Computing membantu cloud computing dalam pemrosesan dan penyimpanan data sehingga data hasil pembacaan dari perangkat IoT tidak perlu dikirimkan langsung ke cloud computing. Penelitian ini akan melakukan pengujian performa fog computing pada scenario smart home Menggunakan Ifogsim, untuk mengetahui sejauh mana efek fog computing pada peningkatan perfoma dibandingkan pada penggunaan cloud computing pada scenario smart home. Pengujian dilakukan menggunakan dua metric yaitu perbandingan network usage dan average application loop delays antara fog dan cloud computing. Hasil pengujian menunjukkan penggunaan fog computing dapat meningkatkan efisiensi IoT ditinjau dari network usage dan average application loop delays.
A New Distance Stereotest by Autostereoscopic Display Using an Eye-Tracking Method
Authors: Cao Li-Qun , Wang Yuan-Qing , Gao Yuan , Zhou Bi-Ye , Li Xue-ling , Shen Ke-Qiang , Xu Bin , Li Ming-Gao 
Published: June 2022

Objectives: This research aimed to present a novel glasses-free distance random-dot stereotest system (GFDRDSS) using an eye-tracking method.Methods: A single-view autostereoscopic display applying a backlight control system combined with an eye-tracking method and the corresponding random-dot stereotest software were developed to create a GFDRDSS with a viewing distance of 5 m. The stereoacuity of 12 subjects with normal eye position was evaluated using the Randot Stereotest, Stereoscopic Test Charts vol. 3 (Yan’s Charts), Distance Randot® Stereotest, and GFDRDSS.Results: The GFDRDSS could provide distinct and stable glasses-free stereoscopic perception even while the subject was moving their head. It could evaluate binocular disparities of 40–2,400 arcsec. Eleven subjects with normal near visual acuity had fine near stereovision (20–60 arcsec) using the Randot stereotest and Yan’s Charts. Under refractive correction, 10 subjects had fine stereovision (≤60 arcsec) using the GFDRDSS at a distance of 5 m, and 9 had fine stereovision using the Distance Randot® Stereotest at 3 m. Other subjects described the 100 arcsec-level stereograms correctly. The results exhibited a concordance of stereoacuity within one degrade between the two distance stereotests.Conclusion: The proposed GFDRDSS can alternately project a couple of random-dot stereograms to the subjects’ eyes and provide a glasses-free distance stereotest, which showed good concordance with the Distance Randot® Stereotest. More data are needed for statistical studies.
Engineering the Active Site Pocket to Enhance the Catalytic Efficiency of a Novel Feruloyl Esterase Derived From Human Intestinal Bacteria Dorea formicigenerans
Authors: Shen Yang , Wang Yulu , Wei Xue , Wen Boting , Liu Shujun , Tan Huishuang , Zhang Jingjian , Shao Shuli , Xin Fengjiao 
Published: June 2022

The human gut microbiota play essential roles in metabolism and human health, especially by enzymatically utilizing dietary fiber that the host cannot directly digest and releasing functional components including short-chain fatty acids (SCFAs) and hydroxycinnamic acids (e.g., ferulic acid). In our previous study, seven potential feruloyl esterase (FAE) genes were identified from the gut microbiota. In the current work, one of the genes encoding a novel FAE (DfFAE) from Dorea formicigenerans of Firmicutes was bacterially expressed, purified and characterized. The 30.5 kDa type-A DfFAE has an optimum pH and temperature of 8.4 and 40 °C, respectively, exhibiting a higher substrate specificity toward short-chain acyl-ester substrate (pNPA). The AlphaFold2 based ab initio structural modeling revealed a five α-helices cap domain that shaped an unusually narrow and deep active site pocket containing a specific substrate access tunnel in DfFAE. Furthermore, rational design strategy was subjected to the active site pocket in an aim of improving its enzymatic activities. The mutants V252A, N156A, W255A, P149A, and P186A showed 1.8 to 5.7-fold increase in catalytic efficiency toward pNPA, while W255A also exhibited altered substrate preference toward long-chain substrate pNPO (45.5-fold). This study highlighted an unusual active site architecture in DfFAE that influenced its substrate selectivity and illustrated the applicability of rational design for enhanced enzymatic properties.
Alterations in Inflammatory Cytokines and Redox Homeostasis in LPS-Induced Pancreatic Beta-Cell Toxicity and Mitochondrial Stress: Protection by Azadirachtin
Authors: John Annie , Raza Haider 
Published: June 2022

Inflammation and redox imbalance are hallmarks of cancer, diabetes, and other degenerative disorders. Pathophysiological response to these disorders leads to oxidative stress and mitochondrial dysfunction by alterations and reprogramming in cellular signaling and metabolism. Pancreatic beta cells are very sensitive to the inflammatory and altered nutrient signals and hence play a crucial role in diabetes and cancer. In this study, we treated insulin-secreting pancreatic beta cells, Rin-5F, with the bacterial endotoxin, LPS (1 μg/ml) to induce an inflammatory response in vitro and then treated the cells with a known anti-inflammatory, anticancer and antioxidant phytochemical, azadirachtin (AZD, 25 µM for 24 h). Our results demonstrated lipid peroxidation and nitric oxide production causing increased nitro/oxidative stress and alterations in the activities of anti-oxidant enzymes, superoxide dismutase and catalase after LPS treatment. Pro-inflammatory responses caused by translocation of nuclear factor kappa B and release of inflammatory cytokines were also observed. These changes were accompanied by GSH-dependent redox imbalance and alterations in mitochondrial membrane potential and respiratory complexes enzyme activities leading to mitochondrial respiratory dysfunction, reduced ATP synthesis, and intrinsic caspase-9 mediated apoptosis. Caspase-9 was activated due to alterations in Bcl-2 and Bax proteins and release of cytochrome c into the cytosol. The activities of oxidative stress-sensitive mitochondrial matrix enzymes, aconitase, and glutamate dehydrogenase were also inhibited. Treatment with AZD showed beneficial effects on the recovery of antioxidant enzymes, inflammatory responses, and mitochondrial functions. GSH-dependent redox homeostasis also recovered after the treatment with AZD. This study may help in better understanding the etiology and pathogenesis of inflammation-induced disorders in pancreatic beta cells to better manage therapeutic strategies.
Urinary Fatty Acid Binding Protein 3 Has Prognostic Value in Peripheral Artery Disease
Authors: Li Ben , Zamzam Abdelrahman , Syed Muzammil H. , Jahanpour Niousha , Jain Shubha , Abdin Rawand , Qadura Mohammad 
Published: June 2022

BackgroundDespite its significant association with limb loss and death, peripheral artery disease (PAD) remains underdiagnosed and undertreated. The current accepted gold-standard for PAD screening, the ankle brachial index (ABI), is limited by operator dependence, erroneous interpretation, and unreliability in patients with diabetes. Fatty acid binding protein 3 (FABP3) is an intracellular protein that becomes released into circulation and excreted into urine following skeletal muscle injury. We examined the prognostic ability of urinary FABP3 (uFABP3) in predicting adverse PAD-related events.MethodsIn this prospective case-control study, urine samples were collected from patients with PAD (n = 142) and without PAD (n = 72). The cohort was followed for 2 years. uFABP3 was normalized to urinary creatinine (uCr) (uFABP3/uCr). The primary outcome was major adverse limb event (MALE; composite of vascular intervention [open or endovascular] or major limb amputation). The secondary outcome was worsening PAD status (drop in ABI≥0.15). Cox regression analyses with multivariable adjustment for baseline demographic and clinical variables were performed to assess the prognostic value of uFABP3/uCr with regards to predicting MALE and worsening PAD status.ResultsPatients with PAD had significantly higher median [IQR] uFABP3/uCr levels (3.46 [2.45–6.90] vs. 2.61 [1.98–4.62], p = 0.001). MALE and worsening PAD status were observed in 21 (10%) and 28 (14%) patients, respectively. uFABP3/uCr predicted MALE and worsening PAD status with adjusted hazard ratios (HR) of 1.28 (1.16–1.41, p = 0.001) and 1.16 (1.02–1.27, p = 0.021), respectively. Patients with high uFABP3/uCr had a lower 2-year freedom from MALE (86 vs. 96%, p = 0.047) and worsening PAD status (78 vs. 99%, p = 0.001). There was good discriminatory ability for uFABP3/uCr in predicting the primary outcome of MALE, with an area under the receiver operating characteristics curve (AUROC) of 0.78.ConclusionsMeasuring uFABP3/uCr levels in patients with PAD can help identify those at high risk of adverse PAD-related events. This study highlights the prognostic value of uFABP3 in risk-stratifying individuals for further diagnostic vascular evaluation or aggressive medical management.
Clinical Implications of Phenotypes of Hemodialysis Patients With Central Venous Occlusion or Central Venous Stenosis Defined by Cluster Analysis
Authors: Wen Chunyong , Chen Bin , Lin Run , Dai Haitao , Tang Keyu , Zhang Guiyuan , Huang Jiawen , Liao Changli , Zeng Linyuan , Xiang Xianhong , Yang Jianyong , Huang Yonghui 
Published: June 2022

ObjectiveThis study aims to investigate the association between clinical factors of patients with central (superior vena cava, brachiocephalic, or subclavian) venous occlusion or central venous stenosis (CVO/CVS) and the difficulty of interventional recanalization as well as the duration of postoperative patency.MethodsA total of 103 hemodialysis patients with CVO/CVS treated with endovascular treatment were enrolled. The two-step cluster analysis was selected to differentiate the cases into distinct phenotypes automatically. Differences in characteristics, the difficulty of interventional recanalization, and the duration of postoperative primary patency time between the two clusters were statistically compared.ResultsThe 103 cases were divided into distinct two clusters by the two-step cluster analysis with 48 (46.6%) in cluster 1 and 55 (53.4%) in cluster 2. Compared to cluster 2, patients in cluster 1 have a higher proportion of blunt stump, side branches, occlusion lesions &gt;2 cm, calcification, or organization. Moreover, the above four factors were, in turn, the most critical four predictors distinguishing 103 patients into two clusters. The remaining six factors were, in turn, occlusion located in the superior vena cava (SVC), duration of central venous catheterization (CVC), lesion location, vessel diameter, number of CVC, and previously failed lesion. Of the four most important factors, with the exception of occlusion lesions exceeding 2 cm, there were significant differences in the length of procedure time between the groups grouped by the remaining three factors. And there was a significant difference in the primary patency rate between the group with blunt stump and the group without blunt stump and also between the group with occlusion lesions ≥ 2 cm and the group with occlusion lesions &lt;2 cm. The operation time of cluster 1 was longer than that of cluster 2. In terms of postoperative patency time, the primary patency time was significantly longer in the patients of cluster 2 compared with cluster 1 (P = 0.025).ConclusionPatients were divided into distinct two clusters. CVO/CVS of patients in cluster 1 was more challenging to be recanalized than that in cluster 2, and the primary patency time was significantly longer in the patients of cluster 2 compared with cluster 1. Blunt stump, side branches, occlusion lesions exceeding 2 cm, and calcification or organization are the four most critical predictors distinguishing 103 patients into two clusters.
Global Rates of Subaerial Volcanism on Earth
Authors: Papale Paolo , Garg Deepak , Marzocchi Warner 
Published: June 2022

Knowledge of the global rates of volcanism is fundamental for modeling the Earth, as those rates closely relate to plate tectonics, crustal growth, mantle dynamics, atmospheric evolution, climate change, and virtually any aspect of the global Earth dynamics. In spite of their huge relevance, the global rates of volcanism have remained unknown, hidden within data that appeared disordered, largely fragmented and incomplete, reflecting poor preservation of small eruptions in the geological record, rareness of large eruptions, and distributions far from normal. Here we describe and validate a model that reproduces global volcanism to high statistical significance, and that is so simple to comfortably fit on a t-shirt. We use the model to compute the expected rates of global terrestrial volcanism over time windows from 1 to 100,000 years, and validate it by comparing with observations back to a few million years. Notably, the model can be tested against independent observations collected in the near future, a feature which is relatively uncommon among global models of Solid Earth dynamics.
Development and Evaluation of an eLearning Training Module to Improve United Kingdom Secondary School Teachers’ Knowledge and Confidence in Supporting Young People Who Self-Harm
Authors: Price Claire , Satherley Rose-Marie , Jones Christina J. , John Mary 
Published: June 2022

BackgroundSelf-harm is a major public health concern with evidence suggesting that the rates are higher in the United Kingdom than anywhere else in Europe. Increasingly, policy highlights the role of school staff in supporting young people (YP) who are self-harming, yet research indicates that school staff often feel ill-equipped to provide support and address self-harm behaviors. Here, we assess the impact of a bespoke eLearning module for United Kingdom secondary school teachers on teacher’s actual and perceived knowledge of self-harm, and their self-reported confidence in supporting and talking to YP who self-harm.MethodsTwenty-one secondary schools across the West Midlands and South East of England were invited to complete a 30-min web-based eLearning module on self-harm in schools. Participants completed pre-and post-intervention measures.ResultsOne-hundred and seventy-three teachers completed the eLearning, and pre-and post-measures. The eLearning significantly enhanced participants’ perceived knowledge, actual knowledge, and confidence in talking to and supporting YP who self-harm. The majority of participants (90.7%) felt that eLearning was a good way to receive training.ConclusionThe 30-min eLearning module was rated highly and may be an effective way to increase secondary school teachers’ knowledge of self-harm, and confidence in supporting and talking to YP who self-harm.
Effects of Different Prolonged Light Durations on Survival, Growth and Physiology of the Eelgrass Zostera marina
Authors: Zhang Yan-Hao , Li Jian-Du , Wu Zhong-Xun , Yuan Shun-Jie , Li Wen-Tao , Zhang Pei-Dong 
Published: June 2022

Prolongation of light duration is one of the effective methods to improve the current seagrass propagation technique. We subjected plants of eelgrass Zostera marina to different prolonged light durations [0 (control), 2, 4, 6, 8 h d−1] for 6 weeks under controlled laboratory conditions. We measured plant response in terms of survivorship, growth, productivity, leaf pigment and carbohydrate concentrations. Survival analysis combined with growth assessment suggested that the optimum range of prolonged light durations for the establishment of Z. marina plants is 3.9–4.6 h d−1. The propagation coefficient of Z. marina plants exposed to 4 h d−1 was 1.4 times higher than that of plants under the control. Pearson and Mantel correlation analysis indicated that the promotion of prolonged light duration to the survival and growth of Z. marina plants mainly depended on the increase of chlorophyll content and the accumulation and synthesis of non-structural carbohydrate. The total chlorophyll content of leaves and soluble sugar content of aboveground tissues of Z. marina plants exposed to 4 h d−1 were 1.6 times and 2.9 times higher than those of plants under the control, respectively. The results will provide data that could prove helpful in the development of efficient artificial propagation technology of Z. marina plants.
Insidious Attentional Deficits in Patients With Cerebral Small Vessel Disease Revealed by Attention Network Test
Authors: Guo Yunliang , Zhao Shuo , Hou Xunyao , Nie Shanjing , Xu Song , Hong Yan , Chen Yali , Guo Shougang , Liu Xueping , Xia Zhangyong 
Published: June 2022

BackgroundSeveral reports have indicated potential cognitive decline for cerebral small vessel disease (CSVD), especially in attention domain, whereas the attentional function at network level is still elusive. In this study, we used the attention network test (ANT) paradigm to characterize the efficiency of the alerting, orienting, and executive control networks in patients with CSVD and explore possible correlations between attention network efficiencies and obtained CSVD total score.MethodsA total of 31 patients with CSVD and 30 healthy controls matched for age, gender, and education level were recruited. After neuropsychological and anxiety/depression/somatization assessments, an original version of ANT containing different cue conditions and target stimuli was used to investigate independent attentional components, and then, behavioral performance (accuracy and reaction time) and network efficacy were recorded and analyzed.ResultsAssessed by traditional neuropsychological scale (MoCA), we did not find difference between groups on general cognition. Nevertheless, the overall reaction time to targets of ANT was markedly prolonged in patients with CSVD, and similar phenomenon was observed for overall accuracy on ANT. Moreover, patients showed significantly lower orienting and executive control network efficiencies compared with controls, while not for alerting network. These impairments were correlated with total CSVD burdens, but not with anxiety, depression, or somatization.ConclusionsAlthough general and almost all individual cognitive function evaluated by MoCA seemed to remain intact, the orienting and executive control function was impaired in individuals with CSVD, which was modulated by lesion grades. Our observations implied insidious attentional deficits regarding CSVD. Given this, considering its simplicity and sensitivity, ANT could serve as an attractive tool for early diagnosis of cognitive dysfunction. Further investigations on the availability of ANT detection for CSVD are warranted.