bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of kinesiotaping on disability and pain in patients with rotator cuff tendinopathy: double-blind randomized clinical trial
Authors: Taik Fatima Zahrae , Karkouri Samia , Tahiri Latifa , Aachari Ilham , Moulay Berkchi Jihad , Hmamouchi Ihsane , Abouqal Redouane , Rkain Hanan , Allali Fadoua 
Published: January 2022

Abstract
Background
Kinesiotaping (KT) is widely used in several musculoskeletal disorders particularly in shoulder pain. However, literature shows controversial results regarding the effect of KT on shoulder pathology. The aim of this study was to assess the clinical effects of KT in the short term on rotator cuff tendinopathy (RCT).

Methods
A randomized controlled double-blind clinical trial was conducted. The sample consisted of 50 subjects (25 per group). Patients were randomly assigned to the KT group (to receive therapeutic KT application) or to the placebo group (to receive sham KT application). Taping was applied every 4 days, a total of three times during the study period. We assessed the patients at baseline, at the end of taping period (D12), and at one-month post-taping (D30). Primary outcome was assessed through the Arabic version of the Disabilities of the Arm, Shoulder and Hand questionnaire (DASH). Secondary outcomes were assessed through Visual Analogue Scale (VAS) for pain intensity at rest (VASr), during active movement (VASm), and at night (VASn).

Results
There were no significant differences between the two groups in the demographic and clinical characteristics and the pre-test scores. Results of repeated measures ANOVA showed significant improvement in DASH scores and in VAS for pain (at rest, during active movement and at night) from D12 in both groups. The use of ANCOVA, controlling for pre-test scores, showed no significant differences between groups, except for VASm at D30.

Conclusion
This study showed that the standardized therapeutic KT used for shoulder pain was not superior to a sham KT application in improving pain and disabilities in patients with RCT.

Trial registration
The study was retrospectively registered on Pan African Clinical Trial Registry (identification number: PACTR202007672254335) on 21/07/2020. https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=12200
Intraoperative radiation therapy for early stage breast cancer
Authors: Zangouri Vahid , Nasrollahi Hamid , Taheri Ali , Akrami Majid , Arasteh Peyman , Hamedi Seyed Hassan , Johari Masoumeh Ghoddusi , Karimaghaee Nazanin , Ranjbar Aliye , Karami Mohammad Yasin , Tahmasebi Sedigheh , Mosalaei Ahmad , Talei Abdolrasoul 
Published: January 2022

Abstract
Background and objective
We report our experiences with Intraoperative radiation therapy (IORT) among breast cancer (BC) patients in our region.

Methods
All patients who received radical IORT from April 2014 on to March 2020 were included in the study. Patient selection criteria included: Age equal or older than 45 years old; All cases of invasive carcinomas (in cases of lobular carcinomas only with MRI and confirmation); Patients who were 45–50 years old with a tumor size of 0–2 cm, 50–55 years old with a tumor size of < 2.5 cm, and those who were ≥ 55 years old with a tumor size of < 3 cm; Invasive tumors only with a negative margin; Negative nodal status (exception in patients with micrometastasis); A positive estrogen receptor status. Primary endpoints included death and recurrence which were assessed using the Kaplan–Meier method.

Results
Overall, 252 patients entered the study. Mean (SD) age of patients was 56.43 ± 7.79 years. In total, 32.9% of patients had a family history of BC. Mean (SD) tumor size was 1.56 ± 0.55 cm. Mean (IQR) follow-up of patients was 36.3 ± 18.7 months. Overall, 8 patients (3.1%) experienced recurrence in follow-up visits (disease-free-survival of 96.1%), among which four (1.5%) were local recurrence, two (0.8%) were regional recurrence and two patients (0.8%) had metastasis. Median (IQR) time to recurrence was 46 (22, 53.7) months among the eight patient who had recurrence. Overall, one patient died due to metastasis in our series. Eleven patients (4.3%) with DCIS in our study received IORT. All these patients had free margins in histopathology examination and none experienced recurrence.

Conclusion
Inhere we reported our experience with the use of IORT in a region where facilities for IORT are limited using our modified criteria for patient selection.
Case report of enterobacter hormaechei in sheep with respiratory disease and death
Authors: Shi Hongfei , Wang Kun , Wang Li , Sun Shiyu , Li Bozhen , Yao Lunguang 
Published: January 2022

Abstract
Background
Enterobacter hormaechei is typically a opportunistic pathogenic bacterium in humans, and no pathological change of of Enterobacter hormaechei in diseased sheep has previously been documented.

Case presentation
Three free-range, four-month-old female sheep were ill with respiratory disease and died three days after receiving treatment with ceftiofur sodium. A frozen lung sample of one sheep was studied using bacterium isolation, and lung samples of the other two sheep were collected and analyzed by histopathological examination and bacterium isolation. The 16S rRNA gene sequences and biochemical characteristics of the isolates were analyzed. All results showed the isolated strain to be Enterobacter hormaechei. Phylogenetic analysis of the 16S rRNA sequence showed three representative strains were most closely related to the strains isolated from calf. Antimicrobial sensitivity tests indicated that no sensitivity to the β-lactam antimicrobials involved in treatment of sheep respiratory disease in China. Detection of the genes responsible for β-lactam resistance showed that all three isolates from sheep harbor blaSHV and blaKPC. Interstitial pneumonia, bronchial epithelial cells shedding, and massive mucous secretion were observed in the lung histopathological sections. Immunohistochemical staining showed that specific staining was mainly limited to the alveoli and alveolar septum.

Conclusions
This appears to be the first report of pathological changes in lungs of sheep with respiratory disease and death associated with Enterobacter hormaechei.
An efficient overexpression method for studying genes in Ricinus that transport vectorized agrochemicals
Authors: Xiao Yongxin , Zhang Jinying , Li Yiting , Hsiang Tom , Zhang Xingping , Zhu Yongxing , Du Xiaoying , Yin Junliang , Li Junkai 
Published: January 2022

Abstract
Background
Plant plasma membrane transporters play essential roles during the translocation of vectorized agrochemicals. Therefore, transporters associated with phloem loading of vectorized agrochemicals have drawn increasing attention. As a model system, castor bean (Ricinus communis L.) has been widely used to detect the phloem mobility of agrochemicals. However, there is still a lack of an efficient protocol for the Ricinus seedling model system that can be directly used to investigate the recognition and phloem loading functions of plasmalemma transporters toward vectorized agrochemicals.

Results
Here, using vacuum infiltration strategy, we overexpressed the coding gene for enhanced green fluorescent protein (eGFP) in R. communis seedlings by Agrobacterium tumefaciens-mediated transformation system. Strong fluorescence signals were observed in leaves, demonstrating that exogenous genes can be successfully overexpressed in seedlings. Subsequently, gene expression time and vacuum infiltration parameters were optimized. Observation of fluorescence and qRT-PCR analysis showed that eGFP strength and expression level reached a peak at 72 h after overexpression in seedlings. Parameter optimization showed Agrobacterium concentration at OD600 = 1.2, and infiltration for 20 min (0.09 MPa), return to atmospheric pressure, and then infiltration for another 20 min, were the suitable transformation conditions. To test the application of vacuum agroinfiltration in directly examining the loading functions of plasma membrane transporters to vectorized agrochemicals in seedlings, two LHT (lysine/histidine transporter) genes, RcLHT1 and RcLHT7, were overexpressed. Subcellular localization showed the strong fluorescent signals of the fusion proteins RcLHT1-eGFP and RcLHT7-eGFP were observed on the cell membrane of mesophyll cells, and their relative expression levels determined by qRT-PCR were up-regulated 47- and 52-fold, respectively. Furthermore, the concentrations of l-Val-PCA (l-valine-phenazine-1-carboxylic acid conjugate) in phloem sap collected from seedling sieve tubes were significantly increased 1.9- and 2.3-fold after overexpression of RcLHT1 and RcLHT7, respectively, implying their roles in recognition and phloem loading of l-Val-PCA.

Conclusions
We successfully constructed a transient expression system in Ricinus seedlings and laid the foundation for researchers to directly investigate the loading functions of plasma membrane transporters to vectorized agrochemicals in the Ricinus system.
Intraoperative practices to prevent wrong-level spine surgery: a survey among 105 spine surgeons in the United Kingdom
Authors: Naqvi Ali Zain , Magill Henry , Anjarwalla Naffis 
Published: January 2022

Abstract
Background
Current literature suggests that wrong-level spine surgery is relatively common with far-reaching consequences. This study aims to assess the current practices of spinal surgeons across the UK with respect to the techniques implemented for correct level verification.

Methods
To assess the current practices of spinal surgeons across the UK with respect to the techniques implemented for level verification. The authors hypothesise the absence of a standardised technique used across spine surgeons in the UK. Practices amongst respondents will be ascertained via an electronic questionnaire designed to evaluate current practices of spinal surgeons whom are members of the British Association of Spinal Surgeons (BASS). The study data will include key information such as; the level of surgical experience, specific techniques used to perform level checks for each procedure and prior involvement with wrong-level spine surgery. Responses were collected over the period of 1 month with a reminder sent 2 weeks prior to closure of the survey. The data were collated and descriptive analyses performed on multiple-choice question answers and common themes established from free text answers.

Results
A total of 27% (n = 105/383) members responded. The vast majority had greater than 10 years’ experience. Intraoperative practices varied greatly with varying practices present for cervical, thoracic and lumbar level surgery. Only 38% (n = 40) of respondents re-checked the level intra-operatively, prior to instrumentation. Of the respondents 47.5% (n = 29/61) of surgeons had been involved in wrong level spinal surgery.

Conclusion
This study highlights the varying practices amongst spinal surgeons and suggests root cause for wrong-level spine surgery; where the level identified pre-incision was subsequently not the level exposed. We describe a novel safety-check adopted at our institute using concepts and lessons learnt from the WHO Checklist.
Spontaneous quorum-sensing hierarchy reprogramming in Pseudomonas aeruginosa laboratory strain PAO1
Authors: Cheng Xiaoyan , Lu Mingqi , Qiu Huifang , Li Yuanhao , Huang Linfeng , Dai Weijun 
Published: January 2022

AbstractPseudomonas aeruginosa strain PAO1 has been commonly used in the laboratory, with frequent genome variations reported. Quorum sensing (QS), a cell–cell communication system, plays important role in controlling a variety of virulence factors. However, the evolution and adaptability of QS in those laboratory strains are still poorly understood. Here we used the QS reporter and whole-genome sequencing (WGS) to systematically investigate the QS phenotypes and corresponding genetic basis in collected laboratory PAO1 strains. We found that the PAO1-z strain has an inactive LasR protein, while bearing an active Rhl QS system and exhibiting QS-controlled protease-positive activity. Our study revealed that an 18-bp insertion in mexT gene gave rise to the active QS system in the PAO1-z strain. This MexT inactivation restored the QS activity caused by the inactive LasR, showing elevated production of pyocyanin, cyanide and elastase. Our results implied the evolutionary trajectory for the PAO1-z strain, with the evulutionary order from the first Las QS inactivation to the final Rhl QS activation. Our findings point out that QS homeostasis occurs in the laboratory P. aeruginosa strain, offering a potential platform for the QS study in clinical isolates.
BlueFMCW: random frequency hopping radar for mitigation of interference and spoofing
Authors: Moon Thomas , Park Jounsup , Kim Seungmo 
Published: January 2022

AbstractRadars form a central piece in a variety of emerging applications requiring higher degrees of localization. However, two problems are anticipated as more radars are deployed: viz., (i) inter-radar interference and (ii) security attacks. While many prior proposals have addressed the problems, no work in the radar literature addressed them simultaneously. In this context, we introduce a novel frequency-modulated continuous-wave (FMCW) radar scheme (namely, BlueFMCW) that aims to alleviate the damage from interference and active attacks (e.g., spoofing). The technique designs that the waveform randomly hops across multiple frequencies to dilute the damage at a certain frequency. Moreover, we propose a phase alignment algorithm to remove the phase discontinuity while combining the beat signals from the randomly-hopped chirps. The simulation results show that the proposed technique can efficiently mitigate the interference and spoofing signals in various scenarios without costing its resolution.
Influence of urban air pollution on the population in the Klang Valley, Malaysia: a spatial approach
Authors: Mohd Shafie Siti Haslina , Mahmud Mastura , Mohamad Suzani , Rameli Nor Lita Fadilah , Abdullah Ramdzani , Mohamed Ahmad Fariz 
Published: January 2022

Abstract
Background
Urban air pollution resulting from economic growth as well as urbanization impacts the health of inhabitants. This study aims to examine the spatial distribution of particulate matter (PM10) and the risk of exposure for the population in the Klang Valley, an urban conglomeration centred in Kuala Lumpur, Malaysia.

Methods
The inverse distance weighted (IDW) interpolation technique in the ArcGIS platform was used to map the air quality from five air monitoring stations. Spatial statistics of the Global Moran’s I Spatial Autocorrelation and Optimized Hot Spot Analysis were used to estimate the spatial clustering of PM10. The population-weighted exposure level (PWEL) technique was used to calculate the population density susceptible to PM10 and the AirQ+ model was applied to estimate the proportion of the adult population at risk of chronic bronchitis due to long-term exposure to PM10 concentrations in the Klang Valley.

Results
The highest annual mean PM10 concentrations at the Klang station ranged between 80 and 100 μg/m3 from 2000 to 2009 and exceeded the New Malaysia Ambient Air Quality Standard (NMAAQS) and the World Health Organization Air Quality Guidelines (WHOAQG) levels of 40 and 20 μg/m3, respectively. The Moran's I results indicated that the statistically significant clusters of high PM10 in Klang present a health risk to the local community. The PWEL results showed that levels of PM10 in Petaling Jaya exceeded the WHOAQG limits, potentially posing a health risk to the high-density population. The AirQ+ model found Klang to be a significantly high-risk area for chronic bronchitis among the adult population with 804,240 people (with a relative risk of 1.85) in 2009.

Conclusion
These high-risk values are due to rapid urbanization and high motor vehicle usage in the Klang Valley and therefore the impact of PM10 on the population needs to be reduced. This situation should be taken seriously by the Department of Environment and Kuala Lumpur City Hall in addressing air pollution issues through stricter rules on emissions and implementing low-carbon policies to improve the well-being of residents.
Evidence of long-distance coastal sea migration of Atlantic salmon, Salmo salar, smolts from northwest England (River Derwent)
Authors: Green Amy , Honkanen Hannele M. , Ramsden Philip , Shields Brian , del Villar-Guerra Diego , Fletcher Melanie , Walton Silas , Kennedy Richard , Rosell Robert , O’Maoiléidigh Niall , Barry James , Roche William , Whoriskey Fred , Klimley Peter , Adams Colin E. 
Published: January 2022

Abstract
Background
Combining data from multiple acoustic telemetry studies has revealed that west coast England Atlantic salmon (Salmo salar L.) smolts used a northward migration pathway through the Irish Sea to reach their feeding grounds. Hundred Atlantic salmon smolts were captured and tagged in May 2020 in the River Derwent, northwest England as part of an Environment Agency/Natural England funded project.

Results
Three tagged smolts were detected on marine acoustic receivers distributed across two separate arrays from different projects in the Irish Sea. One fish had migrated approximately 262 km in 10 days from the river mouth at Workington Harbour, Cumbria to the northernmost receiver array operated by the SeaMonitor project; this is the longest tracked marine migration of an Atlantic salmon smolt migrating from the United Kingdom. This migrating fish displayed behaviours which resulted in fast northward migration. The remaining two fish were detected on a receiver array operated by a third project: the Collaborative Oceanography and Monitoring for Protected Areas and Species (COMPASS).

Conclusion
These detections further provide evidence that migration to reach marine feeding grounds of at least a proportion of salmon smolts from rivers draining into the Irish Sea is northerly, though without a southern marine array it is impossible to conclude that this is the only route. The pattern of these detections would not have been possible without the collaborative efforts of three distinct and separately funded projects to share data. Further work is required to fully understand migration trajectories in this species on the west coast of the British Isles.
Stunting and associated factors among 6–23 month old children in drought vulnerable kebeles of Demba Gofa district, southern Ethiopia
Authors: Tadele Tuba Tringo , Gebremedhin Chameno Chalite , Markos Makiso Urugo , Fitsum Endale Liben 
Published: January 2022

AbstractBackgroundStunting is impaired linear growth of children: they experience stunting in the first 1000 days after conception and is an indication of chronic malnutrition. Children under the age of two are regarded as the most vulnerable to malnutrition due to their rapid growth and greater exposure to infectious disease.ObjectiveTo assess the magnitude and associated factors of stunting among 6 to 23-month-old children in drought-vulnerable kebeles of the Demba Gofa district, southern Ethiopia.MethodsA community-based cross-sectional study was conducted from February to March 2021. Systematic random sampling was used to select pairs of mothers/caregivers with children aged 6 to 23 months. A semistructured questionnaire and anthropometric measurement were used to collect the data. The data were checked coded and entered into Epi-data version 3.1 and exported to SPSS for Windows version 20.0 for analysis. Simple and multivariable linear regressions were conducted. The level of significance was declared at 95% CI andp-value < 0.05.ResultsThe magnitude of stunting in the study area was 79(21.82%). Household dietary diversity [β = 0.217, 95% CI, 0.093–0.342], early initiation of complementary feeding [β = 0.444, 95% CI, 0.344–0.543], frequency of breastfeeding within 24 h [β = 0.217, 95% CI, 0.179–0.263] and child eating animal source food [β = 0.351, 95% CI, 0.196–0.506] were positively significant predictors of child height/length-for-age (HAZ).ConclusionThe extent of stunting in the study area is relatively lower than that in regional and national reports, but one out of five children were still stunted. Therefore, health education on infant and young child feeding practices should be provided to mothers to reduce the problem.
Ethical perspectives of certified public accountants and the cannabis industry
Authors: Owens-Ott G. Suzanne , Snyder Johnny , Ott Richard 
Published: January 2022

Abstract
Background
Certified public accountants must follow very high standards of ethical conduct as set forth by the AICPA Code of Professional Conduct and individual state licensing requirements. A 2019 grounded theory qualitative study posed that CPAs remain largely hesitant to serve the cannabis industry primarily because they fear federal prosecution as long as cannabis remains on the DEA’s Schedule I Drug List. The purpose of this research was to determine the perceptions of CPAs regarding providing accounting services to the cannabis industry in states that have legalized cannabis usage. This study investigated whether CPAs would serve the industry, why they might decline to serve the industry, what risks they believe serving the industry posed, and whether they believe serving the cannabis industry would create a moral or ethical issue.

Methods
This follow-up quantitative study investigated a small convenience sample of approximately one hundred CPAs in Colorado and Washington to learn more about their perceptions of serving the cannabis industry. Data was analyzed using chi-square and Mann-Whitney U tests to determine if there were any differences in perceptions between groups such as states, gender, and age categories.

Results
Of the participants, 77% responded that neither they nor their firm provided services to a cannabis-related business client compared to 23% that did serve cannabis clients. More Colorado CPAs were willing to turn down CRB work than were expected and fewer Colorado CPAs would be willing to take on CRB clients than were expected. While in Washington, fewer CPAs would turn down RB clients than expected, and more are willing to accept CRB clients than were expected. The risk due to potential liability coverage issues due to serving the cannabis industry was rated the highest while the risk of losing the CPA license was rated lowest. Data indicated that there was not a statistically significant difference between Colorado and Washington participants related to whether they were morally or religiously opposed to working in the industry or if they viewed serving the industry as an ethical violation.

Conclusion
CPAs remain largely unwilling to serve the cannabis industry primarily because CPAs fear federal prosecution as long as cannabis remains on the DEA’s Schedule I Drug Listing. The results of this study indicate that while most CPAs are not morally or religiously opposed to serving the industry, about half still believe doing so may constitute an ethical violation for a CPA.