bluuebunny/crossref_metadata_2025_split huggingface dataset:
COMPUTER-BASED PREDICTION OF ACUTE TOXICITY, SIDE-EFFECTS AND TOXIC EFFECTS OF NEW PIPERIDINE DERIVATIVES
Authors: Хайитова М.Д. , Ю В.К. , Сатбаева Е.М. , Малкова Т.В. , Жумакова С.С. , Нургожин Т.С. , Гасанов Е.К. 
Published: November 2022

В настоящее время актуальна проблема ограниченной эффективности и высокого риска возникновения тяжелых побочных явлений при применении многих лекарственных средств. Одним из путей решения проблемы является поиск и изучение малотоксичных соединений, которые могут послужить основой для разработки новых лекарственных средств. Новые соединения производных пиперидина представляют особый интерес в этой сфере. Проведено исследование прогноза острой токсичности и нежелательных побочных и токсических эффектов новых производных пиперидина с использованием онлайн ресурсов PASS и GUSAR на платформе Way2Drug. По результатам прогноза было установлено, что новые модифицированные производные пиперидина являются малотоксичными соединениями при основных путях введения, имеют достаточно ограниченный спектр побочных и токсических эффектов и перспективны для дальнейшего изучения фармакологической активности.
The problem of limited efficacy and a high risk of severe side effects with the use of many drugs is relevant nowadays. One of the ways to solve the problem is the search and study of low-toxic compounds that can serve as the basis for the development of new drugs. New compounds of piperidine derivatives are of particular interest in this area. A study of the prediction of acute toxicity and undesirable side and toxic effects of new piperidine derivatives was carried out using the online resources PASS and GUSAR on the Way2Drug platform. According to the results of the forecast, it was found that the new modified piperidine derivatives are low-toxic compounds in the main routes of administration, have a fairly limited range of side and toxic effects, and are promising for further study of pharmacological activity.
Unidade de Conservação, Turismo e Comunidades tradicionais: aspectos sobre o caso da comunidade de Pinheiro - Diamantina/MG
Authors: Santos Beatriz Roque dos , Nascimento Alan Faber do , Gonçalves Janice Queiroz de Pinho , Fontana Rosislene de Fátima 
Published: November 2022

A presença e uso humano das áreas naturais fizeram com que os órgãos públicos pensassem e elaborem políticas públicas voltadas para a preservação e conservação ambiental. No Brasil, as chamadas Unidades de Conservação possuem planos de manejos e leis que visam preservar o ambiente em que estão inseridas. Diante desse aparato regulatório, este trabalho tem como objetivo analisar a aplicabilidade das políticas públicas ambientais da gestão do Instituto Estadual de Florestas- IEF na comunidade de Pinheiro pertencente ao entorno do Parque Estadual do Biribir-PEBI e propor ações de promoção do turismo rural na perspectiva comunitária. Para isso, foi usado como metodologia o levantamento bibliográfico e documental, além da observação do cotidiano da comunidade e a pesquisa de campo com aplicação de entrevistas. Os resultados mostraram que as ações previstas foram desenvolvidas em sua quase totalidade pelas gestões do parque durante os 23 anos de existência da Unidade de Conservação na região e que a comunidade vê na atividade turística uma saída para promover a inserção social em áreas ambientalmente protegidas, são favoráveis a essa prática, contanto que haja apoio do poder público para o desenvolvimento das atividades comunitárias dentro e no entorno da Unidade de Conservação.
Sosyal Uyumda Kültürlerarası Yaklaşımın Bir Yansıması Olarak Göçmen Meclisleri
Authors: MURSÜL Damla 
Published: November 2022

Sosyal uyum, günümüz koşullarında, hiç olmadığı kadar tartışılan problematik konulardan biri olarak karşımıza çıkmaktadır. Özellikle son dönemde göçün hızlanması ve farklılaşması neticesinde küresel dünyanın aktörlerini zorlayan birtakım gelişmeler yaşanmaktadır. Kendine özgü koşullarda gerçekleşen birbirinden farklı göç deneyimleri, devletlerin siyasi ve idari yüklerinin artmasına ve çözüme yönelik arayış içerisine girmelerine neden olmaktadır. Bu yükü paylaşan aktörlerden biri de yerelde örgütlenen göçmen meclisleridir.
Çalışmanın amacı; göç, çokkültürlülük ve uyum üçgeninde önemli bir role sahip olduğu düşünülen göçmen meclislerini kültürlerarası yaklaşım çerçevesinde değerlendirmektir. Nitel bir araştırma tasarımına sahip olan çalışmada göçmen meclislerinin betimsel bir analizi yapılmaya çalışılacak, Türkiye ve Dünyadan örneklerle bu mekanizmaların işleyişleri mevcut ulusal ve uluslararası düzenlemelerle birlikte değerlendirilecektir. Böylece ilk bakışta küresel bir sorun olarak değerlendirilen göç olgusunun çözümlenmesinde yerel dinamiklerin önemi ve gücü, özellikle Türkiye’de henüz yeterince göz önünde olmayan, yerel bir aktör olan göçmen meclisleri bağlamında ortaya konmuş olacaktır.
Nerve Injury Model in Rabbits: Benefits and Pitfalls
Authors: P. Thayer Wesley , C. Chaker Sara 
Published: November 2022

Peripheral nerve injury is widely studied through the sciatic nerve injury model. Although many animal models are used for sciatic nerve injury studies, rabbits are reported as the third most commonly used animal model. However, there is a significant gap in the literature describing common postoperative complications following sciatic nerve injury in rabbits. This chapter analyzed postoperative complications recorded from an original study that tested 40 mm sciatic nerve gap repairs in 56 rabbits. Autophagy of the toes and pressure ulcer development on the injured limb were the two most common and severe postoperative complications seen. These impairments ultimately led to 23.2% of the rabbits requiring euthanasia prior to the study endpoint. This raised the cost of the study by over $25,000. This chapter outlines the risks and benefits of using this animal model in sciatic nerve injury studies. It also proposes treatment methods for common postoperative complications that can substantially reduce future study costs. To preserve ethical animal care standards in research, we recommend alternative models be used instead of rabbits to study sciatic nerve injuries. However, if rabbits must be used, we encourage using the treatment protocol outlined below.
Analysis and Optimization of Bead Geometry by Using Response Surface Methodology
Authors: Ahmad Asif , Alam Shahnawaz , Sharma Meenu 
Published: November 2022

Analysis of bead geometry is very important in product design and manufacturing. Defect-free products with reliability are the demanding parameter in the manufacturing Industry. In this study, we have analyzed and optimized bead geometry parameters such as height of reinforcement (HOR), depth of Heat Affected Zone (DOH), and width of Heat Affected Zone (WOH) by using Central Composite Design (CCD) of response surface methodology (RSM). In this study, peak current and pulse frequency are the most important process parameters for HOR and the optimum combination obtained are (160 A, 80 A, 100 Hz, and 45%) further HOR at this optimum was found to be 1.41 mm, which is close to 1.45 mm. Similarly, peak current and pulse frequency are the most important process parameter for WOH and the optimum combination obtained are (160 A, 80 A, 150 Hz, and 45%) further WOH at this optimum was found to be 1.32 mm, which is close to 1.37 mm. Again, similarly peak current and pulse frequency are the most important process parameter for DOH and the optimum combination obtained are (160 A, 80 A, 100 Hz, and 45%) further DOH at this optimum was found to be 1.26 mm which is close to 1.58 mm.
El mito de Pigmalión en el filme Lars and the real girl (2007): revisión del motivo de la mujer artificial desde una perspectiva de género
Authors: García Fleitas María de la Luz 
Published: November 2022

This work focuses on the presence of the Pygmalion myth in Lars and the Real Girl (2007), a film directed by Craig Gillespie. The Pygmalion myth has been analyzed so far as a key narrative underlying the whole film. Since classical myths are mediated by a patriarchal, androcentric, and misogynistic gaze, a complementary/alternative gendered reading appears to be highly relevant in this case. Both the Pygmalion myth and the cinematic rewriting of it portray the real conditions of a society that has over the centuries been characterized for significant gender asymmetries and resistance tochange. In sum, we have engaged in a dialogue with our cultural tradition in order to foster awareness of gender discrimination. Grounded in a thorough process of analysis and reflection, we ultimately hope to shed new light on this subject while moving forward towards the creation of alternative scenarios.
El presente trabajo se centra en la presencia del mito clásico de Pigmalión en el filme Lars and the Real Girl (2007), dirigida por Craig Gillespie. Del mismo modo que el mito es analizado como estructura narrativo del mencionado film, ha parecido pertinente, en tanto que los mitos clásicos proyectan una mirada tanto patriarcal como androcéntrica y misógina, plantear una lectura complementaria y alternativa desde una perspectiva de género: el mito de Pigmalión y la reescritura fílmica objeto de nuestro estudio reflejan la realidad de una sociedad que ha venido manteniendo durante siglos importantes asimetrías y resistencias en lo que a igualdad de género se refiere. En definitiva, hemos establecido un diálogo con nuestra tradición cultural en un intento de favorecer, a partir de la reflexión, la toma de conciencia de tal desigualdad, un primer paso para la creación de escenarios alternativos.
Perjury in Classical Antiquity
Authors: Guimarães Tavares Rafael 
Published: November 2022

The present analysis surveys the diachronic developments of social attitudes concerning oaths in the ancient Greek context, from as early as in the poems of Homer and Hesiod, passing through Herodotus’s and Thucydides’s accounts, until the period following the Peloponnesian War. Its main focus is settled in a more synchronic analysis of the instable period narrated by Xenophon, mainly in his Hellenica, but also taking into account other sources. The conclusions drawn by this inquiry ought to be understood in the general context of the end of the fifth and the beginning of the fourth centuries BCE, and help to explain the political uncertainty of this period. The doubts entertained about the capacity of the gods in punishing perjurers (despite Xenophon’s own religious opinions) and, therefore, a questioning of the effectiveness of oaths as an institution coordinating the inter-relations among Greek poleis are not only causes of the instability of this period, but also its results.
El presente análisis examina los desarrollos diacrónicos de las actitudes sociales con respecto a los juramentos en el contexto griego antiguo, desde los poemas de Homero y Hesíodo, pasando por los relatos de Heródoto y Tucídides, hasta el período posterior a la Guerra del Peloponeso. Su enfoque principal se asienta en un análisis más sincrónico del período inestable narrado por Jenofonte, principalmente en su Helénica, pero también teniendo en cuenta otras fuentes. Las conclusiones extraídas de esta indagación deben entenderse en el contexto general de finales del siglo V y principios del IV a. e. c. y ayudan a explicar la incertidumbre política de este período. Las dudas sobre la capacidad de los dioses para castigar a los perjuros (pese a las opiniones religiosas del propio Jenofonte) y, por tanto, el cuestionamiento de la eficacia de los juramentos como institución coordinadora de las interrelaciones entre las poleis griegas no son sólo causas de la inestabilidad de este pero también sus resultados.
Bianca Maria d’Este, donna di cultura e modello di civiltà: l’epistola 19.01 di francesco filelfo
Authors: Santapaola Daniele 
Published: November 2022

Bianca Maria, a lady of the Este family, was a woman of recognised wit and great intelligence who, thanks to her erudition, was able to make her way in a world dominated by the presence and interests of men, earning their esteem. This work examines one of the epistles that Francesco Filelfo, driven by his admiration, addressed to Bianca Maria, the only female figure who appears as addressee of his im-mense collection of letters, a detail that is certainly not irrelevant.
Bianca Maria, dama de la familia Este, fue una mujer de reconocido ingenio y gran inteligencia, que, gracias a su erudición, supo abrirse camino en un mundo dominado por la presencia y los intereses de los hombres, ganándose su estima. En esta obra se examina una de las epístolas que Francesco Filelfo, empujado por la admiración por la cultura de la mujer, dirigió a Bianca Maria, la única figura femenina que aparece como destinataria de su inmenso epistolario, un pormenor ciertamente no irrelevante.
L’instancabile estro creativo del Filelfo (25 luglio 1398 – 13 luglio 1481) e la sua spregiudicata capacità di soddisfare con le sue lodi il desiderio di gloria dei potenti non lo trattennero dal confrontarsi anche con il genere epico. In questo lavoro è stato preso in considerazione un breve passo tratto dalla Sphortias, il poema dedicato a Francesco Sforza (23 luglio 1401 – 8 marzo 1466), in cui viene presentata la descrizione di una tempesta, topos letterario proprio dell’epica. A partire da questo exemplum, si è cercato, dunque, di mettere in luce i meccanismi della costruzione narrativa dell’opera che, pur affondando le radici nel mare magnum della tradizione epica, sembrerebbe presentare, forse non invano, delle interessanti innovazioni.
Associations ofsNfLwith clinico‐radiological measures in a largeMSpopulation
Authors: Sotirchos Elias S. , Fitzgerald Kathryn C. , Singh Carol M. , Smith Matthew D. , Reyes‐Mantilla Maria , Hersh Carrie M. , Hyland Megan H. , Canissario Ryan , Simmons Sarah B. , Arrambide Georgina , Montalban Xavier , Comabella Manuel , Naismith Robert T. , Qiao Min , Krupp Lauren B. , Nicholas Jacqueline A. , Akgün Katja , Ziemssen Tjalf , Rudick Richard , Fisher Elizabeth , Bermel Robert A. , Mowry Ellen M. , Calabresi Peter A. 
Published: November 2022

AbstractObjectiveEvaluation of serum neurofilament light chain (sNfL), measured using high‐throughput assays on widely accessible platforms in large, real‐world MS populations, is a critical step for sNfL to be utilized in clinical practice.MethodsMultiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS) is a network of healthcare institutions in the United States and Europe collecting standardized clinical/imaging data and biospecimens during routine clinic visits. sNfL was measured in 6974 MS and 201 healthy control (HC) participants, using a high‐throughput, scalable immunoassay.ResultsElevated sNfL levels for age (sNfL‐E) were found in 1238 MS participants (17.8%). Factors associated with sNfL‐E included male sex, younger age, progressive disease subtype, diabetes mellitus, impaired renal function, and active smoking. Higher body mass index (BMI) was associated with lower odds of elevated sNfL. Active treatment with disease‐modifying therapy was associated with lower odds of sNfL‐E. MS participants with sNfL‐E exhibited worse neurological function (patient‐reported disability, walking speed, manual dexterity, and cognitive processing speed), lower brain parenchymal fraction, and higher T2 lesion volume. Longitudinal analyses revealed accelerated short‐term rates of whole brain atrophy in sNfL‐E participants and higher odds of new T2 lesion development, although both MS participants with or without sNfL‐E exhibited faster rates of whole brain atrophy compared to HC. Findings were consistent in analyses examining age‐normative sNfL Z‐scores as a continuous variable.InterpretationElevated sNfL is associated with clinical disability, inflammatory disease activity, and whole brain atrophy in MS, but interpretation needs to account for comorbidities including impaired renal function, diabetes, and smoking.
Manipulating the Formation of 2D/3D Heterostructure in Stable High‐Performance Printable CsPbI3Perovskite Solar Cells
Authors: Du Yachao , Tian Qingwen , Wang Shiqiang , Yang Tinghuan , Yin Lei , Zhang Hao , Cai Weilun , Wu Yin , Huang Wenliang , Zhang Lu , Zhao Kui , Liu Shengzhong (Frank) 
Published: November 2022

AbstractManipulating the formation process of the 2D/3D perovskite heterostructure, including its nucleation/growth dynamics and phase transition pathway, plays a critical role in controlling the charge transport between 2D and 3D crystals, and consequently, the scalable fabrication of efficient and stable perovskite solar cells. Herein, the structural evolution and phase transition pathways of the ligand‐dependent 2D perovskite atop the 3D surface are revealed using time‐resolved X‐ray scattering. The results show that the ligand size and shape have a critical influence on the final 2D structure. In particular, ligands with smaller sizes and more reactive sites tend to form then = 1 phase. Increasing the ligand size and decreasing the reactive sites promote the transformation from 3D ton = 3 andn < 3 phases. These findings are useful for the rational design of the phase distribution in 2D perovskites to balance the charge transport and stability of the perovskite films. Finally, solar cells based on ambient‐printed CsPbI3with n‐butylammonium iodide treatment achieve an improved efficiency of 20.33%, which is the highest reported value for printed inorganic perovskite solar cells.
Engineered Switchable‐Wettability Surfaces for Multi‐Path Directional Transportation of Droplets and Subaqueous Bubbles
Authors: Xie Dongdong , Sun Yunna , Wu Yongjin , Wang Kai , Wang Guilian , Zang Faheng , Ding Guifu 
Published: November 2022

AbstractConventional engineered surfaces for fluid manipulation are hindered by the set wettability, and thus they can only achieve spontaneous transport of single‐phase fluid, namely liquid or gas. Moreover, fluid transport systems that are robust to path defects have yet to be fully explored. Here, unprecedentedly, a universal wettability switching strategy is developed for achieving programmable directional transport of both droplets and subaqueous bubbles on a dumbbell‐patterned functional surface (DPFS), featuring in strong robustness, high efficiency, and effective cost. By tuning the superwettability of DPFS through octadecyltrichlorosilane treatment and ultraviolet‐C selective irradiation, the transport fluid can alternate between liquid and gas. The material's switchable superwettability regulates the fluid directed dynamics within the confined pattern, in which the sustaining fluid propelling relies on the surface energy difference between the starting and terminal sites. This enables the construction of multiple channels, which works synergistically with ultralow‐volume‐loss transport to impart the fluidic system with strong robustness against path defects. Underlying the completion of complex microfluidics tasks, spatially‐selective cooling devices and subaqueous gas microreactors are successfully demonstrated. This energy‐consumption‐free fluid transport system opens a new avenue for on‐chip programmable fluid manipulation, promoting innovative applications requiring rational control of two‐phase fluid transport.
Phenethyl isothiocyanate inhibits CD133+/CD90+ liver cancer stem cells by modulation of microRNA‐214‐β‐catenin epigenome axis
Authors: Chu Yi C. , Lin Sheng‐Tsai , Setiawan Syahru A. , Hsieh Ming‐Shou , Yadav Vijesh K. , Huang Ting‐Yi , Yeh Chi‐Tai , Chen Ming‐Yao 
Published: November 2022

AbstractHepatocellular carcinoma (HCC) represents one of the most prevalent and lethal type of malignancies around the globe. Despite the advancement in medical research and therapeutics development, HCC still remains a taunting challenge in clinical settings. Recent studies indicate that the presence of cancer stem cells (CSCs) may be the underlying factor for treatment failure, distant metastasis, and disease recurrence. Elevated stemness gene expression has been correlated to disease stage and poorer prognosis in HCC patients. Initially, we established that β‐catenin is highly expressed in HCC clinical samples. We subsequently re‐validated the idea that CD133+/CD90+ subpopulation cells exhibited CSCs properties including elevated stemness expression (β‐catenin, Nanog, c‐Myc, and Twist1), increased self‐renewal capacity and metastatic potential. Using this cell model, we tested the potential anti‐CSCs effects of phenethyl isothiocynanate (PEITC), a phytochemical isolated from cruciferous vegetables. Treatment of PEITC led to a decreased percentage of CD133+/CD90+ cells in both Huh7 and Sk‐Hep1 cell lines. In addition, PEITC suppressed stemness gene expression, self‐renewal ability, and metastatic potential in HCC CSCs. Mechanistically, PEITC conveyed its anti‐CSCs effects via upregulating microRNA‐214, a negative regulator of β‐catenin. In conclusion, we provided evidence that PEITC could suppress HCC CSCs generation/maintenance. With further clinical testing, PEITC could be used either alone or in combination with currently available chemotherapeutic agents to achieve improved efficacy.
Toward comprehensive value assessment for Alzheimer's disease innovations
Authors: Ferrell Phyllis B. , Fillit Howard , Neumann Peter J. , Wall J. K. , Murray James F. 
Published: November 2022

AbstractIntroductionAssessing medical technologies for Alzheimer's disease (AD) creates challenges for current methods of value assessment. New value assessment approaches for AD are also needed.MethodsWe adapted concepts from health economics to help guide decision makers to more informed decisions about AD therapies and diagnostics.ResultsWe propose a value framework based on five categories: perspective, value elements, analysis, reporting, and decision making. AD value assessments should include the perspective of the patient–caregiver dyad. We propose a broader array of value elements than currently used. Analytics and decision methods can synthesize evidence for all elements of value. Decisions should use a “deliberative appraisal” approach informed by the composite evidence and be transparently reported.DiscussionUsing the proposed framework, the value of forthcoming innovations for AD may be more thoroughly assessed for and by all stakeholders. It can guide decision makers to carefully consider all relevant elements of value contributing to more holistic and transparent decision making.Research Highlights
Alzheimer's disease challenges common methods of evaluating medical technology.
Using current methods, new AD innovations might not be appropriately valued.
Poor value assessments will adversely affect patient access to AD innovations.
A full AD value framework expands perspective, elements, analysis, decision‐making, reporting.
Asymmetric Hydrophosphinylation of Alkynes: Facile Access to Axially Chiral Styrene‐Phosphines
Authors: Cai Baohua , Cui Yuan , Zhou Jian , Wang Yong‐Bin , Yang Limin , Tan Bin , Wang Jun (Joelle) 
Published: November 2022

AbstractA Cu/CPA co‐catalytic system has been developed for achieving the direct hydrophosphinylation of alkynes with phosphine oxides in delivering novel axially chiral phosphorus‐containing alkenes in high yields and excellent enantioselectivities (up to 99 % yield and 99 % ee). DFT calculations were performed to elucidate the reaction pathway and the origin of enantiocontrol. This streamlined and modular methodology establishes a new platform for the design and application of new axially chiral styrene‐phosphine ligands.