bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonopioid perioperative analgesia in head and neck cancer surgery: A systematic review
Authors: Go Beatrice C. , Go Cammille C. , Chorath Kevin , Moreira Alvaro , Rajasekaran Karthik 
Published: May 2022

AbstractObjectiveManagement of postoperative pain after head and neck cancer surgery is a complex issue, requiring a careful balance of analgesic properties and side effects. The objective of this review is to discuss the efficacy and safety of multimodal analgesia (MMA) for these patients.MethodsPubmed, Cochrane, Embase, Scopus, and clinicaltrials.gov were systematically searched for all comparative studies of patients receiving MMA (nonsteroidal anti‐inflammatory drugs (NSAIDs), acetaminophen, anticonvulsants, local anesthetics, and corticosteroids) for head and neck cancer surgeries. The primary outcome was additional postoperative opioid usage, and secondary outcomes included subjective pain scores, complications, adverse effects, and 30‐day outcomes.ResultsA total of five studies representing 592 patients (MMA, n = 275; non‐MMA, n = 317) met inclusion criteria. The most commonly used agents were gabapentin, NSAIDs, and acetaminophen (n = 221), NSAIDs (n = 221), followed by corticosteroids (n = 35), dextromethorphan (n = 40), and local nerve block (n = 19). Four studies described a significant decrease in overall postoperative narcotic usage with two studies reporting a significant decrease in hospital time. Subjective pain scores widely varied with two studies reporting reduced pain at postoperative day 3. There were no differences in surgical outcomes, medical complications, adverse effects, or 30‐day mortality and readmission rates.ConclusionMMA is an increasingly popular strategy that may reduce dependence on opioids for the treatment of postoperative pain. A variety of regimens and protocols are available for providers to utilize in the appropriate head and neck cancer patient.
Detecting lymphoproliferative disease virus in wild turkeys using cloacal swabs
Authors: Shea Stephanie A. , Gonnerman Matthew B. , Blomberg Erik J. , Sullivan Kelsey M. , Kamath Pauline L. 
Published: May 2022

AbstractThe monitoring of infectious diseases in wildlife is crucial for assessing animal health, pathogen range expansion, and the risk of spillover to naive species, but may be resource and labor intensive. Lymphoproliferative disease virus (LPDV) is an avian oncogenic retrovirus that was first identified in wild turkeys (Meleagris gallopavo) in 2009, though it historically caused mortality in domestic turkeys in Europe and Israel. Subsequent surveys detected a high prevalence and broad distribution throughout the eastern United States, warranting further research on LPDV in wild turkey populations. Current LPDV diagnostics require the collection of tissues, such as bone marrow from dead birds or blood during live capture. In our study, we assessed the sensitivity (true positive) and specificity (true negative) of cloacal swab samples as an alternative LPDV detection method. We compared results from cloacal swab samples with both postmortem detection from bone marrow and antemortem detection from blood, using a multi‐tube PCR approach with 3 replicates. Swab samples collected from live‐captured turkeys had a greater sensitivity (88%) than swabs collected from hunter‐harvested turkeys (31%), whereas specificity was similar for both collection approaches (live‐capture swabs = 75%, n = 85; hunter‐harvest swabs = 80%, n = 54). In live‐captured turkeys, the estimated LPDV prevalence using cloacal swab samples (73%) was not significantly different from the true prevalence determined using coupled blood samples (76%). However, in hunter‐harvested turkeys, the estimated prevalence using cloacal swab samples (28%) was different from the true prevalence estimated using coupled bone marrow samples (72%). In summary, cloacal swab samples can be used to reliably detect LPDV infection in live‐captured wild turkeys but should not be used for LPDV detection in hunter‐harvested wild turkeys.
The Object of Investigation
Authors: Johnson Benjamin 
Published: May 2022

AbstractThe discovery of ammonia synthesis from the elements forms the basis of discussion for many topics including fertilizer and food, environmental protection, the repercussions of scientific research, and economic transformation, as well as other industrial, political, and social events. The story in this book focuses on the development of the natural sciences and delves into the details of the scientific history of ammonia synthesis. The resulting narrative provides a basis for yet another discussion: the interaction between scientists and how they proceed in their scientific endeavor. The account helps us better contextualize the completion of the scientific research on ammonia and frame the ensuing technological developments along with the consequences for our world, both constructive and destructive.
The Scientific Publications on Ammonia Synthesis
Authors: Johnson Benjamin 
Published: May 2022

AbstractHaving set the stage, we now turn to the analysis of Haber’s and Nernst’s published results between 1905 and 1908. A short commentary is in order here—both on style and on the use of theory. In summarizing the articles to emphasize pertinent scientific content, it was not possible to express the tone of the century-old publications and the interested reader is encouraged to review the original sources.
The Structure of The Haze
Authors: Johnson Benjamin 
Published: May 2022

AbstractA general structure of the Haze has already been suggested by the title of Part I: A Confluence of Factors. Both the temporal juxtaposition of events, which eventually, albeit at an unknown point in time, results in the arena for discovery, as well as the experimental and theoretical scientific details contribute in differing yet interdependent ways. There is no “grand design,” neither in the minds of those ultimately responsible for the decisions nor in the outcome of individual experiments.
Risk and the Acceptance of Failure
Authors: Johnson Benjamin 
Published: May 2022

AbstractIn the end of Part I, I discussed another aspect of advancement: the willingness to take a risk in order to increase the likelihood of making considerable progress but also of coming up empty handed. Through the Silicon Valley Model, for example, industrial players have been able to incorporate risk taking and the acceptance of failure into their business models. It is not only in the tech industry that we see the repercussions.
The State of Ammonia Synthesis at the Turn of the Twentieth Century: The Arena for Discovery
Authors: Johnson Benjamin 
Published: May 2022

AbstractWhen Fritz Haber took up the problem of ammonia synthesis in 1903 there were several methods of obtaining fixed nitrogen, both naturally and through synthesis in chemical reactions. The main natural sources were Chile saltpeter (sodium nitrate from South America) and ammonium sulfate from gas works and coking (and still some guano).
Generalized symmetries of the graviton
Authors: Benedetti Valentin , Casini Horacio , Magán Javier M. 
Published: May 2022

Abstract
We find the set of generalized symmetries associated with the free graviton theory in four dimensions. These are generated by gauge invariant topological operators that violate Haag duality in ring-like regions. As expected from general QFT grounds, we find a set of “electric” and a dual set of “magnetic” topological operators and compute their algebra. To do so, we describe the theory using phase space gauge-invariant electric and magnetic dual variables constructed out of the curvature tensor. Electric and magnetic fields satisfy a set of constraints equivalent to the ones of a stress tensor of a 3d CFT. The constraints give place to a group ℝ20 of topological operators that are charged under space-time symmetries. Finally, we discuss similarities and differences between linearized gravity and tensor gauge theories that have been introduced recently in the context of fractonic systems in condensed matter physics.
Quantum off-shell recursion relation
Authors: Lee Kanghoon 
Published: May 2022

Abstract
We construct off-shell recursion relations for arbitrary loop-level scattering amplitudes beyond the conventional tree-level recursion relations for ϕ4-theory and the Yang-Mills theory. We define a quantum perturbiner expansion that includes loop corrections from the quantum effective action formalism by identifying the external source. Our method clearly shows how the perturbiner expansion becomes an off-shell current generating function. Instead of using the classical equations of motion in the conventional perturbiner method, we exploit the Dyson-Schwinger equation to derive the quantum off-shell recursion relation to arbitrary order of loop-level scattering amplitudes. We solve the recursion relation and reproduce the results which agree up to one-loop six-point scattering amplitudes for ϕ4-theory. Furthermore, we construct the recursions for computing loop-level correlation functions by replacing the choice of the external source.
Radiation Risk in Cold War Mexico: Local and Global Networks
Authors: Barahona Ana 
Published: May 2022

AbstractAfter WWII, global concerns about the uses of nuclear energy and radiation sources in agriculture, medicine, and industry brought about calls for radiation protection. At the beginning of the 1960s radiation protection involved the identification and measurement of all sources of radiation to which a population was exposed, and the evaluation and assessment of populations in terms of the biological hazard their exposure posed. Mexico was not an exception to this international trend. This paper goes back to the origins of the first studies on the effects of radiation and on radioprotective compounds in the Genetics and Radiobiology Program of the National Commission of Nuclear Energy founded in 1960, at a time when the effects of radiation on living beings and radiation protection demanded the attention of highly localized groups of scientists and the creation of international as well as national institutions, and its connection to dosimetry and radiation protection until the 1990s. This historical reconstruction examines the circulation of knowledge, scientists, and their material and cognitive resources, to show that radiobiology, with dosimetry and radiation protection as cases in point, not only were carried out with high international standards in parallel with international agencies, but also reflected local material needs, including the standardization of new experimental techniques.
N-Player Games and Mean Field Games of Moderate Interactions
Authors: Flandoli Franco , Ghio Maddalena , Livieri Giulia 
Published: May 2022

AbstractWe study the asymptotic organization among many optimizing individuals interacting in a suitable “moderate" way. We justify this limiting game by proving that its solution provides approximate Nash equilibria for large but finite player games. This proof depends upon the derivation of a law of large numbers for the empirical processes in the limit as the number of players tends to infinity. Because it is of independent interest, we prove this result in full detail. We characterize the solutions of the limiting game via a verification argument.
Stochastic Maximum Principle for Optimal Liquidation with Control-Dependent Terminal Time
Authors: Cesari Riccardo , Zheng Harry 
Published: May 2022

AbstractIn this paper we study a general optimal liquidation problem with a control-dependent stopping time which is the first time the stock holding becomes zero or a fixed terminal time, whichever comes first. We prove a stochastic maximum principle (SMP) which is markedly different in its Hamiltonian condition from that of the standard SMP with fixed terminal time. We present a simple example in which the optimal solution satisfies the SMP in this paper but fails the standard SMP in the literature.
Lower leg symmetry: a Q3D-CT analysis
Authors: Vuurberg Gwendolyn , Dahmen Jari , Dobbe Iwan G. G. , Kleipool Roeland P. , Hayat Batur , Sierevelt Inger N. , Streekstra Geert , Kerkhoffs Gino M. M. J. , Stufkens Sjoerd A. S. 
Published: May 2022

Abstract
Purpose
In fracture and realignment surgery, the contralateral unaffected side is often used as a model or template for the injured bone even though clinically valuable quantitative data of bilateral symmetry are often unavailable. Therefore, the objective of the present study was to quantify and present the bilateral symmetry of the tibia and fibula.

Methods
Twenty bilateral lower-leg CT scans were acquired in healthy volunteers. The left and right tibia and fibula were segmented resulting in three-dimensional polygons for geometrical analyses (volume, surface and length). The distal and proximal segment of the right tibia of each individual was subsequently matched to the left tibia to quantify alignment differences (translation and rotation). Bone symmetry on group level was assessed using the Student’s t test and intra-individual differences were assessed using mixed-models analyses.

Results
Intra-individuals differences were found for tibia volume (5.2 ± 3.3 cm3), tibia surface (5.2 ± 3.3 cm2), translations in the lateral (X-axis; 9.3 ± 8.9 mm) and anterior direction (Y-axis; 7.1 ± 7.0 mm), for tibia length (translation along Z-axis: 3.1 ± 2.4 mm), varus/valgus (φz: 1.7o ± 1.4°), and endotorsion/exotorsion (φz: 4.0o ± 2.7°).

Conclusion
This study shows intra-individual tibia asymmetry in both geometric and alignment parameters of which the surgeon needs to be aware in pre-operative planning. The high correlation between tibia and fibula length allows the ipsilateral fibula to aid in estimating the original tibia length post-injury. Future studies need to establish whether the found asymmetry is clinically relevant when the contralateral side is used as reference in corrective surgery.

Level of evidence
III cohort study.
Government funding of research beyond biomedicine: challenges and opportunities for neuroethology
Authors: Zupanc Günther K. H. , Rössler Wolfgang 
Published: May 2022

AbstractCuriosity-driven research is fundamental for neuroethology and depends crucially on governmental funding. Here, we highlight similarities and differences in funding of curiosity-driven research across countries by comparing two major funding agencies—the National Science Foundation (NSF) in the United States and the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG). We interviewed representatives from each of the two agencies, focusing on general funding trends, levels of young investigator support, career-life balance, and international collaborations. While our analysis revealed a negative trend in NSF funding of biological research, including curiosity-driven research, German researchers in these areas have benefited from a robust positive trend in DFG funding. The main reason for the decrease in curiosity-driven research in the US is that the NSF has only partially been able to compensate for the funding gap resulting from the National Institutes of Health restricting their support to biomedical research using select model organisms. Notwithstanding some differences in funding programs, particularly those relevant for scientists in the postdoctoral phase, both the NSF and DFG clearly support curiosity-driven research.
21st Century alpine climate change
Authors: Kotlarski Sven , Gobiet Andreas , Morin Samuel , Olefs Marc , Rajczak Jan , Samacoïts Raphaëlle 
Published: May 2022

AbstractA comprehensive assessment of twenty-first century climate change in the European Alps is presented. The analysis is based on the EURO-CORDEX regional climate model ensemble available at two grid spacings (12.5 and 50 km) and for three different greenhouse gas emission scenarios (RCPs 2.6, 4.5 and 8.5). The core simulation ensemble has been subject to a dedicated evaluation exercise carried out in the frame of the CH2018 Climate Scenarios for Switzerland. Results reveal that the entire Alpine region will face a warmer climate in the course of the twenty-first century for all emission scenarios considered. Strongest warming is projected for the summer season, for regions south of the main Alpine ridge and for the high-end RCP 8.5 scenario. Depending on the season, medium to high elevations might experience an amplified warming. Model uncertainty can be considerable, but the major warming patterns are consistent across the ensemble. For precipitation, a seasonal shift of precipitation amounts from summer to winter over most parts of the domain is projected. However, model uncertainty is high and individual simulations can show change signals of opposite sign. Daily precipitation intensity is projected to increase in all seasons and all sub-domains, while the wet-day frequency will decrease in the summer season. The projected temperature change in summer is negatively correlated with the precipitation change, i.e. simulations and/or regions with a strong seasonal mean warming typically show a stronger precipitation decrease. By contrast, a positive correlation between temperature change and precipitation change is found for winter. Among other indicators, snow cover will be strongly affected by the projected climatic changes and will be subject to a widespread decrease except for very high elevation settings. In general and for all indicators, the magnitude of the change signals increases with the assumed greenhouse gas forcing, i.e., is smallest for RCP 2.6 and largest for RCP 8.5 with RCP 4.5 being located in between. These results largely agree with previous works based on older generations of RCM ensembles but, due to the comparatively large ensemble size and the high spatial resolution, allow for a more decent assessment of inherent projection uncertainties and of spatial details of future Alpine climate change.
Modelling the effect of ephaptic coupling on spike propagation in peripheral nerve fibres
Authors: Schmidt Helmut , R. Knösche Thomas 
Published: May 2022

AbstractExperimental and theoretical studies have shown that ephaptic coupling leads to the synchronisation and slowing down of spikes propagating along the axons within peripheral nerve bundles. However, the main focus thus far has been on a small number of identical axons, whereas realistic peripheral nerve bundles contain numerous axons with different diameters. Here, we present a computationally efficient spike propagation model, which captures the essential features of propagating spikes and their ephaptic interaction, and facilitates the theoretical investigation of spike volleys in large, heterogeneous fibre bundles. We first lay out the theoretical basis to describe how the spike in an active axon changes the membrane potential of a passive axon. These insights are then incorporated into the spike propagation model, which is calibrated with a biophysically realistic model based on Hodgkin–Huxley dynamics. The fully calibrated model is then applied to fibre bundles with a large number of axons and different types of axon diameter distributions. One key insight of this study is that the heterogeneity of the axonal diameters has a dispersive effect, and that a higher level of heterogeneity requires stronger ephaptic coupling to achieve full synchronisation between spikes.
Adaptive changes in striatal projection neurons explain the long duration response and the emergence of dyskinesias in patients with Parkinson’s disease
Authors: Falkenburger Björn , Kalliakoudas Theodoros , Reichmann Heinz 
Published: May 2022

AbstractNeuronal activity in the brain is tightly regulated. During operation in real time, for instance, feedback and feedforward loops limit excessive excitation. In addition, cell autonomous processes ensure that neurons’ average activity is restored to a setpoint in response to chronic perturbations. These processes are summarized as homeostatic plasticity (Turrigiano in Cold Spring Harb Perspect Biol 4:a005736–a005736, 2012). In the basal ganglia, information is mainly transmitted through disinhibition, which already constraints the possible range of neuronal activity. When this tightly adjusted system is challenged by the chronic decline in dopaminergic neurotransmission in Parkinson’s disease (PD), homeostatic plasticity aims to compensate for this perturbation. We here summarize recent experimental work from animals demonstrating that striatal projection neurons adapt excitability and morphology in response to chronic dopamine depletion and substitution. We relate these cellular processes to clinical observations in patients with PD that cannot be explained by the classical model of basal ganglia function. These include the long duration response to dopaminergic medication that takes weeks to develop and days to wear off. Moreover, dyskinesias are considered signs of excessive dopaminergic neurotransmission in Parkinson’s disease, but they are typically more severe on the body side that is more strongly affected by dopamine depletion. We hypothesize that these clinical observations can be explained by homeostatic plasticity in the basal ganglia, suggesting that plastic changes in response to chronic dopamine depletion and substitution need to be incorporated into models of basal ganglia function. In addition, better understanding the molecular mechanism of homeostatic plasticity might offer new treatment options to avoid motor complications in patients with PD.
Conservation of Forces and Total Work at the Interface Using the Internodes Method
Authors: Deparis Simone , Gervasio Paola 
Published: May 2022

AbstractThe Internodes method is a general purpose method to deal with non-conforming discretizations of partial differential equations on 2D and 3D regions partitioned into disjoint subdomains. In this paper we are interested in measuring how much the Internodes method is conservative across the interface. Ifhp-fem discretizations are employed, we prove that both the total force and total work generated by the numerical solution at the interface of the decomposition vanish in an optimal way when the mesh size tends to zero, i.e., like$\mathcal {O}(h^{p})$O(hp), wherepis the local polynomial degree andhthe mesh-size. This is the same as the error decay in theH1-broken norm. We observe that the conservation properties of a method are intrinsic to the method itself because they depend on the way the interface conditions are enforced rather then on the problem we are called to approximate. For this reason, in this paper, we focus on second-order elliptic PDEs, although we use the terminology (of forces and works) proper of linear elasticity. Two and three dimensional numerical experiments corroborate the theoretical findings, also by comparing Internodes with Mortar and WACA methods.