bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mucosal associated Lymphoid Tissue Lymphoma of the uvea: an analysis of 3 cases
Authors: Wang Zhenyu , Liu Yueming , Mo Jing , Cao Xusheng , Xu Xiaolin , Shen Lin , Wang Hong , Wei Wenbin 
Published: May 2022

Abstract
Background: Ocular MALT lymphoma involving orbit and conjunctiva usually has an indolent clinical course with “salmon patch” mass as typical presentation. This study is to report a series of rare cases and investigate the clinical and pathological features of ocular MALT lymphoma that involved uveal tissue primarily and presented as posterior scleritis.Methods: From 2018 to 2020 in Beijing Tongren Eye Cener, 3 cases of 3 eyes (2 female patients and 1 male patient) with ocular MALT lymphoma that involved uveal tissue primarily and presented as posterior scleritis were included in the study. All patients had complaints of blurred vision and hyperemia in their involved eyes. The average age was 56.33 ± 2.08 years old and the average time from initial diagnosis to pathological diagnosis was 3.00 ± 1.73 months. Ophthalmic examinations including BCVA, IOP, slit lamp microscope examinations, fundus photography, B-scan ultrasonography, UBM, OCT, FFA and ICGA were conducted. Systemic workups including orbital MRI, PET-CT and blood autoimmune antibody tests were also conducted. Pathological tissue from patients were obtained through surgeries. Biopsy examinations were performed to accurately determine pathological diagnosis. All the information of clinical, imaging and pathological changes were collected and analyzed.Results: At the initial diagnosis, the BCVA of involved eyes decreased seriously while the IOP were normal. All involved eyeball showed extensive hyperemia and local thickening in the wall of eyeballs. B-scan ultrasonography showed mass with abundant blood and irregular cysts inside the eyeball wall and in the retrobulbar orbit, surrounding the ocular wall and optic nerve. UBM showed solid lesions with low and medium echo under the conjunctiva and inside the ciliary body of 2 cases. OCT showed posterior polar wavy rise of RPE and local neuroepithelial detachment in all cases. FFA and ICGA showed vascular abnormalities (patch-like strong fluorescence and fluorescence leakage) and local thickening in retina and choroid (Rectangle-like weak fluorescence below the macula). The posterior wall of the eyeball was thickened and enhanced in MRI. PET-CT also showed thickening of posterior wall of eyeballs and increased metabolic activity but there was no sign of autoimmune disease. All patients were diagnosed as MALT lymphoma through pathologic examinations of biopsy tissue.Conclusions: The onset of primary ocular MALT lymphoma in uvea is hidden. The early clinical manifestations are lack of specificity and misleading. B-scan ultrasonography has characteristic manifestations and is valuable in diagnosis. However, pathological diagnosis through tissue biopsy is irreplaceable.
Does fixation of both clavicle and scapula is better than clavicle alone in surgical treatment of floating shoulder injury? A retrospective study
Authors: Shao Yijie , Zhu Xu , Liu Bo , Ji Chenchen , Chen Guangdong 
Published: May 2022

Abstract
Background: Little research was available to explore which surgical fixation was better between fixation of both clavicle and scapula and clavicle alone in management of floating shoulder injury.Methods: Total 69 patients with floating shoulder injury receiving surgery from February 2005 to July 2020 participated in the study. 49 patients underwent fixation of the clavicle alone (Group C) while 20 patients underwent fixation of both clavicle and scapula (Group C+S). They were further divided into subgroups according to age: Group C1, Group C+S1 (age≤55 years old) and Group C2, Group C+S2 (age＞55 years old). The radiological parameter (glenopolar angle (GPA)) and clinical outcomes (Herscovici score, Constant-Murley shoulder outcome score (CSS score), and Visual Analogue Scale score (VAS score)) were collected and compared between these groups. The correlation between age and radiological parameter and clinical outcomes were calculated by the Spearman correlation analysis. Results: All people were followed up for at least 1 year. The degree of change in GPA before and after surgery in Group C+S is significantly better than that in Group C. The Herscovici and CSS score in Group C+S2 were significantly higher than those in Group C2 at 1 month, 3 months and 1 year after surgery. However, no significant difference in Herscovici and CSS score was found at final follow-up (1 year after surgery) between Group C+S1 and Group C1. The VAS score in Group C+S2 at final follow-up was significantly lower than that in Group C2. No significant difference in VAS score at final follow-up was found between Group C+S1 and Group C1. In addition, the VAS score was negatively correlated with Herscovici and CSS score. No correlation was found between VAS score and GPA.Conclusions: Both types of surgical fixation are effective in management of floating shoulder injury. For young people with floating shoulder injury, both types of surgical fixation are equally effective. However, for older people with floating shoulder injury, fixation of both clavicle and scapula is better in prognosis than fixation of clavicle alone.
Does pathological T factor affect the long-term prognosis of locally advanced colorectal cancer treated with Laparoscopic multi-visceral resection?
Authors: Ishiyama Yasuhiro , Hirano Yasumitu , Yonezawa Hiroki , Sasaki Megumi , Fujii Takatugu , Okazaki Naoto , Ishii Toshimasa , Deguchi Katuya 
Published: May 2022

Abstract
Purpose: Local advanced colorectal cancer (LACC) has poor long-term outcomes. Our hypothesis was that the depth of pathological findings would affect postoperative outcomes in patients who underwent multivisceral resection (MVR) resulting in clear margins (R0). The aim of this study was to analyze short- and long-term outcomes in patients who underwent MVR for LACC between T3 and T4 stages.Methods: This was a propensity score-matched (PSM) retrospective study. All 8,764 consecutive patients who underwent surgery for colorectal cancer between April-2007 and January- 2021 at the Saitama Medical University International Medical Center were screened. 572 underwent MVR for LACC. We compared the T3 and T4 groups to evaluate outcomes.Results: The 5-year disease-free survival (DFS) rates did not significantly differ between the two groups (HR 1.344 95% CI (0.638–-2.907), P=0.33). The 5-year overall survival (OS) rates were significantly worse for the T4 group than for the T3 group (HR 3.162 95% CI (1.077–-11.44), P=0.037).To determine the association between American Society of Anesthesiologists (ASA) score, transfusion, pathological T and OS, we performed univariate and multivariate analyses. ASA, transfusion, and pathological T were associated with worse OS in univariate analysis (T3 vs. T4, respectively).Conclusion: Our study showed that the postoperative complications and DFS of the T4 group were similar to those of the T3 group. However, OS was worse in the T4 group compared with T3 group. Multivariate risk factors were ASA>2, transfusion, and, T4.
Incidence, Mortality, and Epidemiology of Leukemia in South Asia: An Ecological Study
Authors: Rifat Rakibul Hasan , Poran Md. Shah , Islam Saiful , Sumaya Anika Tabassum , Alam Md. Mozahidul , Rahman Md Rashedur 
Published: May 2022

Abstract
Nowadays cancer is a buzzword in every corner of the world. Among all other Cancer, leukemia is not as familiar as breast cancer or lung cancer. Treat or curing Cancer is challenging, there is still no worthy hope to fight against it. Back a few decades, Cancer was not that much known to the people of South Asia let alone known of Leukemia. Information on the incidence and mortality of Leukemia is paramount to planning health measures and improving the treatment and management of leukemia for general people. Many countries in the South Asian region are designated as developing countries. Hence, the deficiency of diagnosis system, treatment, management, and lack of knowledge about leukemia in this region are major problems. Therefore, the incidence rate, mortality rate, and several deaths are increasing day by day. This study is aimed to investigate the incidence and mortality of leukemia in South Asian Countries for the year 2020 by acquiring data from the global cancer project (GLOBOCAN2020). India has the highest number of leukemia cases followed by Pakistan and Bangladesh in 2020. Not only the number of cases but also the mortality rates of leukemia are highest in those countries. In contrast, Sri Lanka and Pakistan have the incidence rate instead. Children aged from 0-14 years old and adults aged from 60-85 years old have the highest rate of incidence. This indicates the chances of having leukemia are more in this age ranges than in any other age range.
Association between Dietary Zinc and Self-Reported Eye Affliction/Retinopathy in Individuals with Diabetes: National Health and Nutrition Examination Survey, 2007–2018
Authors: Xu Han , Dong Xinxin , Wang Jin , Chai Ruiyu , Wang Yingshuang , Yao Yan , Jin Lina 
Published: May 2022

Abstract
Background
Emerging evidence supported that dietary zinc is beneficial for diabetes. However, few studies were available concerning the association between dietary zinc and diabetic retinopathy (DR). The present study aimed to describe the association between dietary zinc intake and the risk of DR in US adults.
Methods
A total of 3749 diabetic patients with self-reported eye affliction/retinopathy from the National Health and Nutrition Examination Survey (NHANES) 2007–2018 were involved. Stratified analysis by gender was performed, and logistic regression and restricted cubic spline (RCS) models were applied to assess the association between dietary zinc and DR. Receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value of zinc intake for predicting DR.
Results
Dietary zinc was inversely associated with diabetic retinoapthy in men (OR: 0.981, 95%CI:0.965–0.997), while this trend was not significant in women. Higher quartile of dietary zinc was associated with lower occurrence of diabetic retinopathy (OR: 0.531, 95%CI: 0.334–0.846). Furthermore, increased amounts of dietary zinc was significantly associated with reduced occurrence of diabetic retinopathy (OR: 0.622, 95%CI: 0.411–0.941). ROC analysis identified a daily dietary zinc intake of 7.53 mg as the optimal cut-off value for predicting DR.
Conclusion
Higher levels of dietary zinc are suggested to reduce the risk of diabetic retinopathy and have been observed to have a dose-response effect in men. Assessment of dietary zinc levels may be part of the treatment of patients with diabetic complications.
Time trends in the incidence of cardiovascular disease, hypertension, and diabetes by socioeconomic status in Catalonia, Spain
Authors: Bennett Matthew , Pistillo Andrea , Recalde Martina , Reyes Carlen , Freisling Heinz , Salles Talita Duarte 
Published: May 2022

Abstract
Background: It is unclear how cardiovascular disease, hypertension, and type 2 diabetes mellitus incidence trends have evolved in different population subgroups by age, sex, and socioeconomic status. Our study aims to estimate the trends in cardiovascular disease, hypertension, and type 2 diabetes mellitus incidence in Catalonia, Spain from 2009-2018, considering age, sex, and socioeconomic deprivation.Methods: Our study is a population-based cohort study using prospectively collected data from electronic health records from primary care and hospital settings in Catalonia, Spain, from 2009-2018. Our final study population included 3,247,244 adults (≥40 years). We calculated the annual incidence (per 1000 persons-year) and incidence rate ratios (IRR) between three time periods of cardiovascular disease, hypertension, and type 2 diabetes mellitus to measure trends and changes in incidence during the study period.Results: In 2016-2018 compared to 2009-2012, cardiovascular disease incidence increased in the 40-54 (e.g., IRR=1.61, 95%CI: 1.52-1.69 in women) and 55-69 (1.35, 1.31-1.40 in women) age groups. There was no change in cardiovascular disease incidence in women aged 70+ years, and a slight decrease in men aged 70+ years (0.93, 0.90-0.95). Hypertension incidence decreased in all age groups for both sexes. Type 2 diabetes mellitus incidence decreased in all age groups for both sexes (e.g., 0.72, 0.70-0.73 in women aged 55-69 years), except for the 40-54 year age group (e.g., 1.09, 1.06-1.13 in women). Incidence trends by deprivation for all three conditions mirrored overall trends, although there were higher incidence levels in the most deprived areas, especially in the 40-54 and 55-69 year groups. These differences have remained constant or narrowed in recent years.Conclusions: Overall cardiovascular disease incidence has increased while hypertension and type 2 diabetes mellitus incidence have decreased in the last years in Catalonia, Spain. Differences in trends by age group and socioeconomic deprivation were found. Calling attention to these differences can serve to inform policies aimed at reducing the burden of these conditions and health inequities.
Factors Associated With Poor Quality of Life of Transgender People
Authors: Coswosck Kaio Henrique Cesconetto , Moreira Juliana Almeida , Navarro Joel Hirtz do Nascimento , Guandalini Valdete Regina , Marques-Rocha Jose Luiz 
Published: May 2022

Abstract
Background: The term transgender (TRANS) may be used for people whose gender identity differs from the one assigned at birth. A large part of this population segment faces social (lack of social support, discrimination, rejection, transphobia) and psychological (anxiety, depression) challenges. These factors, in turn, may negatively impact the quality of life (QoL) of these individuals. The aim of this study is to identify factors that influence the quality of life of transgender people when compared with cisgender people (CIS). Methods: Cross-sectional case-control study with non-probability sample, conducted with transgender and cisgender adults living in a southeastern Brazilian state. The research questionnaire was accessed electronically and comprised sociodemographic, health, and QoL information. QoL was assessed through the Short-Form 6 dimensions (SF-6D) instrument. Multivariate logistic regression was used to verify the participation of the independent variables in QoL. Odds ratio (OR) values and their respective confidence intervals (CI) were estimated. The analyses were carried out in the SPSS® software, version 22.0, with a significance level of 5%. Results: The sample included 65 transgender and 78 cisgender individuals. The cisgender group showed a predominance of people with higher education (p=0.002) and higher income (p=0.000) when compared with the transgender group. Transgender participants had worse QoL score (p=0.014) and the same was observed when QoL was assessed by dimension (p≤0.05). In addition, having an income between 1 to 3 minimum wages (MW) reduced by 94.6% (OR=0.054, CI=0.004 – 0.707, p=0.026) the chances of having better QoL, when compared with those with income higher than 3 MW. Living in the state’s capital reduced the chances of having better QoL by 96.2% (OR=0.038, CI=0.004 - 0.387, p=0.006) when compared with those living in the countryside. Conclusion: The transgender population showed worse QoL when compared with the cisgender population, with income and place of residence being the factors that influenced this indicator.
Effect of Carnitine Supplementation in Pediatric Patients with Left Ventricular Dysfunction
Authors: Ikeda Nobuyuki , Loomba Rohit , Patel Riddhi , Dorsey Vincent , Yousef Faeeq , Nelson-McMillan Kristen 
Published: May 2022

Abstract
Carnitine is an essential amino acid involved in transporting fatty acids across the mitochondrial membrane. Fatty acids are a primary source of energy for the myocardium. Studies in adults demonstrated decreased carnitine levels in the ischemic myocardium, but subsequent exogenous carnitine supplementation showed improvement of myocardial metabolism and left ventricular function. However, only limited data regarding carnitine is available in pediatrics. A single-center retrospective, paired data study was conducted. Patients < 18 years, left ventricular ejection fraction (LVEF) < 55% by echocardiography and had received at least 7 days of oral or intravenous carnitine supplementation between January 2018 and March 2021 are included in the study. Several endpoints and covariates were collected for each patient; before, one week after, one month after, and six months after carnitine supplementation. Univariate analysis consisted of an analysis of variance (ANOVA), followed by an analysis of covariance (ANCOVA) to model LVEF while adjusting for other variables. 44 patients included in the final analyses. LVEF significantly improved from 50.5–56.6% (p < 0.01). When LVEF was adjusted for other interventions (mechanical ventilation, afterload reduction, diuretic therapy, spironolactone), the estimated means demonstrated a significant increase from 45.7–58.0% (p < 0.01). Free carnitine level increased significantly (p = 0.03), and N-terminal-pro-brain-natriuretic peptide (p = 0.03), creatinine (p < 0.01), and lactate (p < 0.01) all significantly decreased over the study period. Carnitine supplementation in pediatric patients with left ventricular systolic dysfunction may be associated with an increase in LVEF and improvement in laboratory markers of myocardial stress and cardiac output.
A retrospective study on the cases with congenital cardiac disease and their risk factors applied to Pediatric Cardiology Clinic
Authors: Şanlı Cihat , Agaoglu Said , Kandur Yaşar 
Published: May 2022

Abstract
Many cases of congenital heart disease are multifactorial and result from a combination of genetic predisposition and an as-yet-to-be-determined environmental stimulus. The purpose of the study is to determine the patients who were diagnosed with CHD through echocardiography and to reveal the risk factors that may cause congenital heart anomalies in our center since 2010. The medical records of pediatric patients applied to our pediatric cardiology clinic between 2010–2017 were retrospectively reviewed. A total of 14,173 patients applied to our clinic between 2010–2017. One hundred and fourteen cases diagnosed with CHD by ECHO performed by a pediatric cardiologist were detected. Sixty (52.6%) of the cases were female and 54 (47.4) were male. Seventy-seven of the 114 patients included in the study were acyanotic (67.5%) and 37 (32.5%) were cyanotic. Seventeen of the aycanotic patients had mixed CHD. The mean maternal gestational age was 28.2+/-5.78 years. 26 (22.8%) were born preterm. Seventeen (14,9%) patients were born with low birth weight (under 2500 g). Eight (7%) patients were LGA (large for gestational age) (birth weight over 4000 g). The average birth weight was 2,982.8+/-740,87 gr. Consanguinity was found in the parents of 28 (24.5%) patients. There was a history of CHD in the relatives of 6 (5.2%) patients, siblings of 4 (3.5%) patients, and parents of 5 (4.3%) patients. Chromosomal abnormalities were found in 9 (7.9%) patients. Our study is a valuable contribution to the existing literature in that it showed that the frequency and distribution of congenital heart diseases have not changed in recent years, and its findings are compatible with the literature findings.
Efficacy of live attenuated vaccines after two doses of intravenous immunoglobulin therapy for Kawasaki disease
Authors: Morikawa Yoshihiko , Sakakibara Hiroshi , Miura Masaru 
Published: May 2022

Abstract
BackgroundIt is unclear when live attenuated vaccines (LAV) should be administered to children with Kawasaki disease (KD) who have received a second dose of intravenous immunoglobulin (IVIG) after failing to respond to the initial treatment. The present study aimed to assess the efficacy of LAV after two IVIG treatments and to explore the appropriate timing of vaccination.MethodsThe present, single-arm, prospective, interventional study included KD patients who had no medical history of measles, rubella, varicella, mumps or vaccinations against these diseases and received two IVIG treatments at age 6 months or older. The subjects received vaccinations against these diseases for the first time at six or nine months after their IVIG treatment. IgG specific to each virus was measured by EIA at three months after the initial vaccination. If the results were negative, the subjects received a booster vaccination at 12 months after IVIG treatment. The primary outcome was the prevalence of positivity for antibodies after the initial and booster vaccinations.ResultsThe present study enrolled 11 children, three of whom were vaccinated at six months and eight at nine months after IVIG treatment. One and two subjects who were vaccinated at six months remained negative for measles and rubella antibodies, respectively, but all those vaccinated at nine months were positive. Booster vaccination for measles and rubella led to seroconversion in all patients. At the time of their initial vaccination, all the subjects were negative for mumps antibodies, and about 30% were positive for varicella. Booster vaccinations for mumps and varicella resulted in seroconversion in 82% of the subjects. ConclusionThese findings suggested that six months may be too short an interval after two IVIG treatment before administering measles and rubella vaccines whereas nine months may be adequate. The mumps and varicella vaccines were ineffective at either time point, but a sero-response was obtainable by administering a booster vaccination.Clinical Trial Registration: UMIN-CTR, UMIN000007174, https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&type=summary&recptno=R000008452
Southern Hemisphere Monsoonal System during Superinterglacial Stages: MIS5e, MIS11c and MIS31
Authors: Gurjão Carlos Diego , Justino Flávio , Pires Gabrielle , Senna Mônica , Lindemann Douglas , Rodrigues Jackson 
Published: May 2022

Abstract
Based on coupled climate experiments conducted with the coupled ICTP-CGCM model focusing on interglacial stages MIS5e (127 ka), MIS11c (409 ka) and MIS31 (1,072 ka), the Austral summer monsoonal system is investigated. The interannual variability and intensity of monsoon events are analysed from vorticity indices and air-sea interaction processes for Africa, Australia and South America monsoons. Results demonstrated with respect to present day conditions, an orbital driven decrease in precipitation in summer, but slightly shift of the onset and demise periods of monsoons. Sensitivity experiments indicate, furthermore, that the monsoons are forced not only by external factors such as the dominant effect of insolation, but also by distant climate anomalies, such as surface temperature of the equatorial Atlantic and Pacific basins. During the interglacial stages, cooling occurs in the Southern Hemisphere whereas Northern Hemisphere substantially warms, inducing remarkable changes in the position of the oceanic subtropical high pressure systems and equatorial convergence zone. Regionally, these mechanisms contribute to periods of drought, with reduced precipitation rate over sectors of the Amazon and Northeastern Brazil, northern Australia and southern Africa. Monsoonal rainfall shows different responses to precessional forcing, as well as the relationship between the monsoon and Niño 3.4 differs among the interglacial stages. Compared to current climate, correlation analyses have demonstrated weaker influence of the equatorial Pacific Ocean on the Austral summer monsoon for the MIS5e, MIS11c and MIS31. Exception is noticed for the South America monsoon, where the Niño 3.4 exerts a more prominent role in these distant intervals, in consonance with the tropical Atlantic in particular during the MIS5e.