bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is there any additional benefit of 68Ga-PSMA PET on radiotherapy target volume definition in patients with glioblastoma?
Authors: Şahin Merve , Akgun Elife , Sirolu Sabri , Can Gunay , Sayman Haluk Burcak , Oner Dincbas Fazilet 
Published: August 2022

Objective: To investigate the contribution of 68Gallium (68Ga)-PSMA (prostate-specific membrane antigen) positron emission tomography (PET) in defining radiotherapy (RT) target volume for glioblastoma and to compare the target volumes defined by Magnetic Resonance Imaging (MRI). Methods: RT planning Computed Tomography (CT) images were fused separately with pre-operative MRI and PET/MRI images of 10 glioblastoma patients, retrospectively. The contrast-enhanced area in T 1 weighted MRI was contoured as gross tumor volume (GTV) and clinical target volume (CTV1) was obtained by including the cavity and T2/FLAIR hyperintense areas after giving a margin of 2 cm to the GTV. 68Ga-PSMA uptake area was contoured as biological tumor volume (BTV) and CTV2 was obtained with a margin of 2 cm to BTV. Planning target volumes (PTVs) were created with the 3 mm added to the CTVs. Conformity index (CI), dice similarity coefficient (DSC) and overlap volume (OV) were calculated by obtaining the intersection and union volumes. Volumetric comparison, similarity and overlap analyzes were performed statistically by Wilcoxon signed rank and One sample t-test. Results: The median GTV was 21,96 cc (1,04 – 82,04) and BTV was 25,58 cc (2,43 – 99,47). BTV was on average 47% larger than GTV which was statistically significant (p = 0.03). For GTV-BTV, CTV1-CTV2 and PTV1-PTV2; mean values of CI were 0,56, 0,76 and 0,76; DSC were 0,70, 0,86 and 0,86; OV were 0,88, 0,94 and 0,94, respectively. There was no significant difference on size and spatial similarity between CTV1 and CTV2, PTV1 and PTV2. Conclusion: Altough BTV was larger than GTV, this significance was lost while we gave the same CTV margin including the peripheral edema. It seems that it may help to improve defining non-enhancing tumor part and also recurrent tumor volume. Advances in knowledge: Recent studies have focused on the role of 68Ga-PSMA PET in imaging of glial tumors. It has been observed that 68Ga-PSMA PET can clearly define the tumor borders and it can be beneficial in target volume delineation, especially in reirradiation of recurrent tumors.
Amodiaquine drug pressure selects nonsynonymous mutations in pantothenate kinase 1, diacylglycerol kinase, and phosphatidylinositol-4 kinase in Plasmodium berghei ANKA
Authors: Chepngetich Jean , Muriithi Brenda , Gachie Beatrice , Thiong'o Kevin , Jepkorir Mercy , Gathirwa Jeremiah , Kimani Francis , Mwitari Peter , Kiboi Daniel 
Published: August 2022

Background: Lumefantrine (LM), piperaquine (PQ), and amodiaquine (AQ), the long-acting components of the artemisinin-based combination therapies (ACTs), are a cornerstone of malaria treatment in Africa. Studies have shown that PQ, AQ, and LM resistance may arise independently of predicted modes of action. Protein kinases have emerged as mediators of drug action and efficacy in malaria parasites; however, the link between top druggable Plasmodium kinases with LM, PQ, and AQ resistance remains unclear. Using LM, PQ, or AQ-resistant Plasmodium berghei parasites, we have evaluated the association of choline kinase (CK), pantothenate kinase 1 (PANK1), diacylglycerol kinase (DAGK), and phosphatidylinositol-4 kinase (PI4Kβ), and calcium-dependent protein kinase 1 (CDPK1) with LM, PQ, and AQ resistance in Plasmodium berghei ANKA. Methods: We used in silico bioinformatics tools to identify ligand-binding motifs, active sites, and sequence conservation across the different parasites. We then used PCR and sequencing analysis to probe for single nucleotide polymorphisms (SNPs) within the predicted functional motifs in the CK, PANK1, DAGK, PI4Kβ, and CDPK1. Using qPCR analysis, we finally measured the mRNA amount of PANK1, DAGK, and PI4Kβ at trophozoites and schizonts stages. Results: We reveal sequence conservation and unique ligand-binding motifs in the CK, PANK1, DAGK, PI4Kβ, and CDPK1 across malaria species. DAGK, PANK1, and PI4Kβ possessed nonsynonymous mutations; surprisingly, the mutations only occurred in the AQr parasites. PANK1 acquired Asn394His while DAGK contained K270R and K292R mutations. PI4Kβ had Asp366Asn, Ser1367Arg, Tyr1394Asn and Asp1423Asn. We show downregulation of PANK1, DAGK, and PI4Kβ in the trophozoites but upregulation at the schizonts stages in the AQr parasites. Conclusions: The selective acquisition of the mutations and the differential gene expression in AQ-resistant parasites may signify proteins under AQ pressure. The role of the mutations in the resistant parasites and the impact on drug responses require further investigations in malaria parasites.
Informativeness of Management Accounting As a Business Management Tool
Authors: Vakhorina Marina 
Published: August 2022

The purpose of the study is to generalize theoretical provisions and develop methodological aspects of the management accounting system as a factor in improving the effectiveness of financial indicators to maintain business at a stable level. The tasks and trends of the transition to a management accounting system that reveals the effectiveness of the importance of finance to the owner are determined. The research is based on the integration of the experience of specialists, revealing the practical significance of the management accounting transformation system in order to collect and analyze information for planning and making management decisions, as well as on the analysis of Russian and foreign publications. The article is devoted to the issue of using the information contained in management accounting as a tool for assessing business performance.
The main problems that accompany owners who do not keep management records are disclosed and analyzed. The obtained results are accompanied by elements of scientific novelty and practical significance.
Toward Efficient Ensemble Learning with Structure Constraints: Convergent Algorithms and Applications
Authors: Lin Shao-Bo , Tang Shaojie , Wang Yao , Wang Di 
Published: August 2022

Ensemble learning methods, such as boosting, focus on producing a strong classifier based on numerous weak classifiers. In this paper, we develop a novel ensemble learning method called rescaled boosting with truncation (ReBooT) for binary classification by combining well-known rescaling and regularization ideas in boosting. Theoretically, we present some sufficient conditions for the convergence of ReBooT, derive an almost optimal numerical convergence rate, and deduce fast-learning rates in the framework of statistical learning theory. Experimentally, we conduct both toy simulations and four real-world data runs to show the power of ReBooT. Our results show that, compared with the existing boosting algorithms, ReBooT possesses better learning performance and interpretability in terms of solid theoretical guarantees, perfect structure constraints, and good prediction performance. History: Accepted by Ram Ramesh, Area Editor for Data Science & Machine Learning Funding: This work was supported by the National Natural Science Foundation of China [Grants 11971374, 61772374, and 61876133]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/ijoc.2022.1224 .
Spectrally simplified approach for leveraging legacy geostationary
oceanic observations
Authors: Houskeeper Henry F. , Hooker Stanford B. , Cavanaugh Kyle C. 
Published: August 2022

The use
of multispectral geostationary
satellites to study aquatic ecosystems improves the temporal frequency
of observations and mitigates cloud obstruction, but no operational
capability presently exists for the coastal and inland waters of the
United States. The Advanced Baseline Imager (ABI) on the current
iteration of the Geostationary Operational Environmental Satellites,
termed the

R

Series (GOES-R), however, provides
sub-hourly imagery and the opportunity to overcome this deficit and to
leverage a large repository of existing GOES-R aquatic observations.
The fulfillment of this opportunity is assessed herein using a
spectrally simplified, two-channel aquatic algorithm consistent with
ABI wave bands to estimate the diffuse attenuation coefficient for
photosynthetically available radiation,

K
d

(

P
A
R

)

. First, an in
situ ABI dataset was synthesized using a globally
representative dataset of above- and in-water radiometric data
products. Values of

K
d

(

P
A
R

)

were estimated by fitting the ratio
of the shortest and longest visible wave bands from the in situ ABI dataset to coincident, in situ

K
d

(

P
A
R

)

data products. The algorithm was
evaluated based on an iterative cross-validation analysis in which 80%
of the dataset was randomly partitioned for fitting and the remaining
20% was used for validation. The iteration producing the median
coefficient of determination (

R
2

) value (0.88) resulted in a root mean
square difference of

0.319

m

−
1

, or 8.5% of the range in the
validation dataset. Second, coincident mid-day images of central and
southern California from ABI and from the Moderate Resolution Imaging
Spectroradiometer (MODIS) were compared using Google Earth Engine
(GEE). GEE default ABI reflectance values were adjusted based on a
near infrared signal. Matchups between the ABI and MODIS imagery
indicated similar spatial variability (

R
2

=
0.60

) between ABI adjusted blue-to-red
reflectance ratio values and MODIS default diffuse attenuation
coefficient for spectral downward irradiance at 490 nm,

K
d

(
490
)

, values. This work demonstrates that
if an operational capability to provide ABI aquatic data products was
realized, the spectral configuration of ABI would potentially support
a sub-hourly, visible aquatic data product that is applicable to
water-mass tracing and physical oceanography research.
Synthesis and characterization of gold nanoparticles and graphene oxide for the development of optical fiber biosensors
Authors: Uniyal Shikha , Choudhary Kuldeep , Sachdev Surbhi , Kumar Santosh 
Published: August 2022

Optical fiber technology, in association with the phenomenon of surface plasmon resonance (SPR), has opened a new gateway for quick, easier, and accurate sensing of various chemical, biochemical, and biological parameters. Continuous efforts can be seen in the direction of increasing the sensitivity of the optical fiber biosensors; thus, many hybrid nanostructured optical fiber biosensors composing different nanomaterials, nanomaterial combinations, and different 2D materials have been proposed in the past few decades. This paper discusses the synthesis, characterization, and applications of nanoparticles to the most favorable noble metal for SPR biosensing, i.e., gold. The gold nanoparticles (AuNPs) were prepared by the Turkevich method, and the optical property of AuNPs was characterized using the UV-visible spectrophotometer and transmission electron microscopy (TEM) technique. In addition, the synthesis, characterization, and application of the oxide form the most explored 2D material, i.e., graphene, are also presented in this paper. The graphene oxide was synthesized using an easier and economical method, i.e., a modified Hummer’s method, and an evaluation of the characteristics has been done by a UV-visible spectrophotometer and TEM results.
Optimization of the nonlinear crystal length for high-power single-frequency intracavity frequency-doubling lasers
Authors: Guo Yongrui , Su Jing , Lu Huadong 
Published: August 2022

We report a method of optimizing the nonlinear crystal length of the intracavity frequency-doubling laser, which is achieved by maximizing the output power of the frequency-doubling laser in the case of ensuring the single longitudinal mode (SLM) operation of the laser. The optimal length of the nonlinear crystal for an SLM oscillation of the intracavity frequency-doubling laser is firstly theoretically predicted by comparing the losses introduced by the nonlinear crystal with different lengths with that of ensuring the SLM operation of the laser. Then three nonlinear

L
i
B

3

O

5

(LBO) crystals with the length of 18, 20, and 22 mm are adopted to be the frequency-doubling components in the experiment. By recording the output power and monitoring the longitudinal mode structure of the laser, it is found that the nonlinear LBO crystal with the length of 20 mm is the best candidate, since the output power is higher than that of the LBO crystal with the length of 18 mm, and the SLM operation of the laser is readily achieved compared to that of the LBO crystal with the length of 22 mm. The experimental results well agree with the theoretical predictions. The current method can pave a good way to attain a single-frequency continuous-wave intracavity frequency-doubling laser.
Assessment of Apple Watch Series 6 pulse oximetry and electrocardiograms in a pediatric population
Authors: Littell Lauren , Roelle Lisa , Dalal Aarti , Van Hare George F. , Orr William B. , Miller Nathan , Avari Silva Jennifer N. 
Published: August 2022

Background
Recent technologic advances have resulted in increased development and utilization of direct-to-consumer cardiac wearable devices with various functionality. This study aimed to assess Apple Watch Series 6 (AW6) pulse oximetry and electrocardiography (ECG) in a cohort of pediatric patients.

Methods
This single-center, prospective study enrolled pediatric patients ≥ 3kg and having an ECG and/or pulse oximetry (SpO2) as part of their planned evaluation. Exclusion criteria: 1) non-English speaking patients and 2) patients in state custody. Simultaneous tracings were obtained for SpO2 and ECG with concurrent standard pulse oximeter and 12-lead ECG. AW6 automated rhythm interpretations were compared to physician over-read and categorized as accurate, accurate with missed findings, inconclusive (automated interpretation: “inconclusive”), or inaccurate.

Results
A total of 84 patients were enrolled over a 5-week period. 68 patients (81%) were placed into the SpO2 and ECG arm, with 16 patients (19%) placed into the SpO2 only arm. Pulse oximetry data was successfully collected in 71/84 (85%) patients and ECG data in 61/68 (90%). ΔSpO2 between modalities was 2.0±2.6% (r = 0.76). ΔRR was 43±44msec (r = 0.96), ΔPR 19±23msec (r = 0.79), ΔQRS 12±13msec (r = 0.78), and ΔQT 20±19msec (r = 0.9). The AW6 automated rhythm analysis yielded a 75% specificity and found: 1) 40/61 (65.6%) “accurate”, 2) 6/61 (9.8%) “accurate with missed findings”, 3) 14/61 (23%) “inconclusive”, and 4) 1/61 (1.6%) incorrect.

Conclusion
The AW6 can accurately measure oxygen saturation when compared to hospital pulse oximeters in pediatric patients and provide good quality single lead ECGs that allow for accurate measurement of RR, PR, QRS, and QT intervals with manual interpretation. The AW6-automated rhythm interpretation algorithm has limitations for smaller pediatric patients and patients with abnormal ECGs.
Sociodemographic variation in prescriptions dispensed in early pregnancy in Northern Ireland 2010–2016
Authors: Given Joanne , Casson Karen , Dolk Helen , Loane Maria 
Published: August 2022

AimTo establish the prevalence of prescriptions dispensed in early pregnancy by maternal age and area deprivation, for women who gave birth in Northern Ireland (NI) 2011–2016.Study designPopulation-based linked cohort study.MethodsThe NI Maternity System (NIMATS) database was used to identify all births to resident mothers in NI between 2011 and 2016. Prescriptions dispensed between the last menstrual period (LMP) and the first antenatal care visit (mean 10.7 weeks) (2010–2016) were extracted from the Enhanced Prescribing Database (EPD) which records all prescriptions dispensed by pharmacists in NI. EPD data were linked to NIMATS using the mother’s Health and Care Number. Maternal deprivation based on the NI Multiple Deprivation Measure 2017 was linked using the mother’s postcode.ResultsThe cohort included 139,687 pregnancies resulting in live or stillbirths to 106,206 women. A medication was dispensed in 63.5% of pregnancies, and in 48.7% of pregnancies excluding supplements (vitamins, iron, and folic acid). Folic acid was the most commonly dispensed medication (33.1%). Excluding supplements, the mean number of medications was 1.1, with 4.2% having ≥5 medications. The most common non-supplement medications were antibiotics (13.1%), antiemetics (8.7%), analgesics (6.9%), hormonal medications (6.9%) and antidepressants (6.1%). Younger women (<20 years) had more antibiotics while older women (40+ years) had more antidepressants, cardiovascular, antihypertensives, anticoagulant medications and thyroxine. The proportion of women living in the most deprived areas with prescriptions for antidepressants, sedatives, tranquilisers, analgesics, and anti-epileptic medications was double the proportion of women with these medications in the least deprived areas.ConclusionHalf of all pregnant women in NI were dispensed a non-supplement medication between LMP and the first antenatal care visit. Younger and older mothers and those living in the most deprived areas were more likely to have medications dispensed. More antidepressants were dispensed in areas of social deprivation.
Symptomatic dry eye disease and associated factors among postgraduate students in Ethiopia
Authors: Zeleke Tarekegn Cheklie , Adimassu Nebiyat Feleke , Alemayehu Abiy Maru , Dawud Teshager Wondale , Mersha Getasew Alemu 
Published: August 2022

Background
Symptomatic dry eye disease is a growing public health challenge especially among those who are visual display unit (VDU) users and other long-time near activity workers. Globally, computer user adults experience a surge in the prevalence of dry eye. Data is insufficient on the prevalence of dry eye disease among postgraduate students in Ethiopia. Therefore, the present was aimed to assess the prevalence of dry eye and its associated factors among postgraduate students at the University of Gondar, Northwest Ethiopia.

Methods
A cross-sectional study was conducted on a total of 423 postgraduate students who were selected based on a simple random sampling technique. Data was collected through online symptom-based ocular surface disease index questionnaire. Binary logistic regression was used to test the association and p-value of <0.05 was considered to determine the significance of the association.

Results
From the total postgraduate students, 404 completed the study with a response rate of 95.5%. The prevalence of symptomatic dry eye disease was 50.5% (95% CI, 45.1%-54.9%). Average continuous visual display unit use for 2-4hours per day[AOR = 2.57 (95% CI, 1.27–5.21)] and for> 4hours per day[AOR = 3.77 (95% CI 1.87–7.59)], duration of visual display unit use for 3–5 years [AOR = 2.24 (95% CI, 1.17–4.31)], 6–8 years [AOR = 2.46 (95% CI,1.31–4.62)] and > 8 years [AOR = 3.25 (95% CI, 1.63–6.48)], average sleeping hour < 7 hours/day within last week [AOR = 2.17 (95% CI, 1.35–3.49)] and current known allergic conjunctivitis [AOR = 5.42 (95% CI, 2.43–12.10)] were significantly associated with symptomatic dry eye disease.

Conclusion and recommendation
In this study, about half of postgraduate students faced symptomatic dry eye disease. Significant association was observed between symptomatic dry eye disease and average continuous hours of visual display unit use, duration of visual display unit use in years, shortage of sleep and current known allergic conjunctivitis. It is advisable for postgraduate students to limit screen exposure hour and establish regular breaking time along their exposure. It is also advisable to have optimum sleep as possible. It is also important to explore dry eye disease on a large sample incorporating clinical tests.
Ophthalmologic emergency room visits during COVID-19 lockdown–Characterization from Haifa, Israel
Authors: Naaman Efrat , Bar Nitai , Zaher Elie , Shapira Liran , Blumenthal Eytan Zeev 
Published: August 2022

Purpose
To characterize quantitative differences among ophthalmologic emergency room (OER) encounters at Rambam Health Care Campus during a 6-week complete lockdown at the peak of the first COVID-19 wave as compared to a corresponding uneventful period a year earlier.

Methods
A retrospective chart analysis of all OER encounters during the lockdown and non-lockdown period was conducted. Patients were stratified into primary ophthalmological conditions (OER visits) and cases in which ophthalmologic consultations were requested by a non-ophthalmologist (OER consultations). The following parameters were compared: total number of cases, age, gender, chief complaint/diagnosis categorized into major entities, and discharge vs. hospitalization. For continuous variables a t-test was used and for categorical variables a chi-squared or Fisher’s exact test was used. A 2-sided p value <0.05 was considered statistically significant.

Results
The total number of patients in the lockdown and non-lockdown groups was 486 and 992, respectively, showing a 51% decrease in visits during lockdown. In the non-lockdown and lockdown groups 56% and 61% of patients were male (p = 0.07), with an average age of 42 (range 0–97, SD 23) and 43 (range 0–90, SD 22) years, respectively (p = 0.44). No statistically significant proportional increase was found for any diagnostic category between the OER visits (p = 0.07) and OER consultation groups (p = 0.77). Nevertheless, analysis revealed a non-significant increase in the proportion of eye trauma from 14.8% to 21.2%, and reduction in eyelid conditions from 10.7% to 5.8%. The total number of OER visits demanding urgent intervention on admission was 43 (non-lockdown) and 24 (lockdown), while hospitalization ratio (hospitalizations/visits) was 8.8% and 10.6%, respectively (p = 0.44).

Conclusions
During the COVID-19 lockdown the guideline for patients in Israel was to avoid unnecessary hospital visits. Since patients tended to avoid the OER rather uniformly regardless of their specific eye condition, determining the risk-benefit of such recommendations and identifying high-risk sub-populations are critical public health issues.