bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel echocardiographic right ventricular dysfunction score can identify hemodynamic severity profiles in left ventricular dysfunction
Authors: Bech-Hanssen Odd , Fredholm Martin , Astengo Marco , Bartfay Sven-Erik , Bollano Entela , Dellgren Göran , Karason Kristjan , Ricksten Sven-Erik 
Published: August 2022

Abstract
Purpose
Recognition of congestion and hypoperfusion in patients with chronic left ventricular dysfunction (LVD) has therapeutic and prognostic implications. In the present study we hypothesized that a multiparameter echocardiographic grading of right ventricular dysfunction (RVD) can facilitate the characterization of hemodynamic profiles.

Methods
Consecutive patients (n = 105, age 53 ± 14 years, males 77%, LV ejection fraction 28 ± 11%) referred for heart transplant or heart failure work-up, with catheterization and echocardiography within 48 h, were reviewed retrospectively. Three hemodynamic profiles were defined: compensated LVD (cLVD, normal pulmonary capillary wedge pressure (PCWP < 15 mmHg) and normal mixed venous saturation (SvO2 ≥ 60%)); decompensated LVD (dLVD, with increased PCWP) and LV failure (LVF, increased PCWP and reduced SvO2). We established a 5-point RVD score including pulmonary hypertension, reduced tricuspid annular plane systolic excursion, RV dilatation, ≥ moderate tricuspid regurgitation and increased right atrial pressure.

Results
The RVD score [median (IQR 25%;75%)] showed significant in-between the three groups differences with 1 (0;1), 1 (0.5;2) and 3.0 (2;3.5) in patients with cLVD, dLVD and LVF, respectively. The finding of RVD score ≥ 2 or ≥ 4 increased the likelihood of decompensation or LVF 5.2-fold and 6.7-fold, respectively. On the contrary, RVD score < 1 and < 2 reduced the likelihood 11.1-fold and 25-fold, respectively. The RVD score was more helpful than standard echocardiography regarding identification of hemodynamic profiles.

Conclusions
In this proof of concept study an echocardiographic RVD score identified different hemodynamic severity profiles in patients with chronic LVD and reduced ejection fraction. Further studies are needed to validate its general applicability.

Graphical abstract
Docetaxel-loaded M1 macrophage-derived exosomes for a safe and efficient chemoimmunotherapy of breast cancer
Authors: Zhao Yongmei , Zheng Yuanlin , Zhu Yan , Li Hongyun , Zhu Hongyan , Liu Tianqing 
Published: August 2022

AbstractThe conversion of tumor-promoting M2 macrophage phenotype to tumor-suppressing M1 macrophages is a promising therapeutic approach for cancer treatment. However, the tumor normally provides an abundance of M2 macrophage stimuli, which creates an M2 macrophage-dominant immunosuppressive microenvironment. In our study, docetaxel (DTX) as chemotherapeutic modularity was loaded into M1 macrophage-derived exosomes (M1-Exo) with M1 proinflammatory nature to establish DTX-M1-Exo drug delivery system. We found that DTX-M1-Exo induced naïve M0 macrophages to polarize to M1 phenotype, while failed to repolarize to M2 macrophages upon Interleukin 4 restimulation due to impaired mitochondrial function. This suggests that DTX-M1-Exo can achieve long-term robust M1 activation in immunosuppressive tumor microenvironment. The in vivo results further confirmed that DTX-M1-Exo has a beneficial effect on macrophage infiltration and activation in the tumor tissues. Thus, DTX-M1-Exo is a novel macrophage polarization strategy via combined chemotherapy and immunotherapy to achieve great antitumor therapeutic efficacy.
Stimuli-responsive nanoformulations for CRISPR-Cas9 genome editing
Authors: Fang Tianxu , Cao Xiaona , Ibnat Mysha , Chen Guojun 
Published: August 2022

AbstractThe CRISPR-Cas9 technology has changed the landscape of genome editing and has demonstrated extraordinary potential for treating otherwise incurable diseases. Engineering strategies to enable efficient intracellular delivery of CRISPR-Cas9 components has been a central theme for broadening the impact of the CRISPR-Cas9 technology. Various non-viral delivery systems for CRISPR-Cas9 have been investigated given their favorable safety profiles over viral systems. Many recent efforts have been focused on the development of stimuli-responsive non-viral CRISPR-Cas9 delivery systems, with the goal of achieving efficient and precise genome editing. Stimuli-responsive nanoplatforms are capable of sensing and responding to particular triggers, such as innate biological cues and external stimuli, for controlled CRISPR-Cas9 genome editing. In this Review, we overview the recent advances in stimuli-responsive nanoformulations for CRISPR-Cas9 delivery, highlight the rationale of stimuli and formulation designs, and summarize their biomedical applications.
Early steroids and ventilator-associated pneumonia in COVID-19-related ARDS
Authors: Lamouche-Wilquin Pauline , Souchard Jérôme , Pere Morgane , Raymond Matthieu , Asfar Pierre , Darreau Cédric , Reizine Florian , Hourmant Baptiste , Colin Gwenhaël , Rieul Guillaume , Kergoat Pierre , Frérou Aurélien , Lorber Julien , Auchabie Johann , La Combe Béatrice , Seguin Philippe , Egreteau Pierre-Yves , Morin Jean , Fedun Yannick , Canet Emmanuel , Lascarrou Jean-Baptiste , Delbove Agathe 
Published: August 2022

Abstract
Rationale
Early corticosteroid treatment is used to treat COVID-19-related acute respiratory distress syndrome (ARDS). Infection is a well-documented adverse effect of corticosteroid therapy.

Objectives
To determine whether early corticosteroid therapy to treat COVID-19 ARDS was associated with ventilator-associated pneumonia (VAP).

Methods
We retrospectively included adults with COVID-19-ARDS requiring invasive mechanical ventilation (MV) for ≥ 48 h at any of 15 intensive care units in 2020. We divided the patients into two groups based on whether they did or did not receive corticosteroids within 24 h. The primary outcome was VAP incidence, with death and extubation as competing events. Secondary outcomes were day 90-mortality, MV duration, other organ dysfunctions, and VAP characteristics.

Measurements and main results
Of 670 patients (mean age, 65 years), 369 did and 301 did not receive early corticosteroids. The cumulative VAP incidence was higher with early corticosteroids (adjusted hazard ratio [aHR] 1.29; 95% confidence interval [95% CI] 1.05–1.58; P = 0.016). Antibiotic resistance of VAP bacteria was not different between the two groups (odds ratio 0.94, 95% CI 0.58–1.53; P = 0.81). 90-day mortality was 30.9% with and 24.3% without early corticosteroids, a nonsignificant difference after adjustment on age, SOFA score, and VAP occurrence (aHR 1.15; 95% CI 0.83–1.60; P = 0.411). VAP was associated with higher 90-day mortality (aHR 1.86; 95% CI 1.33–2.61; P = 0.0003).

Conclusions
Early corticosteroid treatment was associated with VAP in patients with COVID-19-ARDS. Although VAP was associated with higher 90-day mortality, early corticosteroid treatment was not. Longitudinal randomized controlled trials of early corticosteroids in COVID-19-ARDS requiring MV are warranted.
Village chicken production and food security: a two-decade bibliometric analysis of global research trends
Authors: Idamokoro Emrobowansan Monday , Hosu Yiseyon Sunday 
Published: August 2022

Abstract
Background
The present study aimed to reveal outputs of research works on village chicken production as a tool to combat food insecurity, taking into account the recurring challenge posed by food shortage and high rise in hunger among vulnerable people of several countries.

Results
On aggregate, 104 publications were obtained in a BibTeX design for analysis using bibliometric package in R studio. The obtained data comprised, but not limited to authors, citations, institutions, key words and journals. Published articles on village chicken production with relation to food security retrieved from web of science (WOS) and Scopus data banks were utilized with a rise in research publications of a yearly growth of 12.93% during the study period. With regard to country, USA was ranked first with an aggregate sum of publications (n = 16), and a huge global academic influence with most top article citations (n = 509). The frequently used authors’ keywords in this studied research area were food security (n = 23), poultry (n = 9), chickens (n = 7), backyard poultry (n = 5), gender (n = 4), which all together created a hint on related studies on village chicken production and food security.

Conclusions
The present study provides a worldwide situation that traverse the intellectual quandary on village chicken production and food security research, and a direction for further researches in this field. It is very vital to emphasize that the current study only dealt with principal areas of village chicken production as related to food security research, hence, it is projected that new empirical research and prospective research findings would afford new knowledge and insight on village chicken production as a means to address food security challenges as new studies evolves.
Development of low-cost RFID sensors dedicated to air pollution monitoring for preventive conservation
Authors: Rioual Stephane , Lescop Benoit , Pellé Julien , de Alkmim Radicchi Gerusa , Chaumat Gilles , Bruni Marie-Dominique , Becker Johan , Thierry Dominique 
Published: August 2022

Abstract
Monitoring of atmospheric pollutants is a key point for preventive conservation since these species are known to impact the integrity of many artifacts including metals, papers, pigment and textiles. The problem can be amplified in closed environments, like in exhibition rooms and showcases, where temperature and relative humidity gradients and levels can introduce additional micro-climatic problems. One objective of the EU-SensMat project concerns the development of low cost and low visual nuisance sensors sensitive to these pollutants, making them affordable for all museums including small ones. For this purpose, the Radio-Frequency Identification (RFID) technology was considered to produce air-quality sensors based on reactive metallic dosimeter. Besides the low cost, they can be easily integrated to other existing RFID applications such as identification tasks since the interrogation is made with a commercial UHF-RFID reader. The description and the main features of these sensors are discussed in this paper. Moreover, as it will be shown, the subsequent chemical analysis of the sensitive part of the sensors provide useful information to determine the origin of the pollutants.
New tool for sustainable treatments: agar spray—research and practice
Authors: Giordano Ambra , Caruso Maria Rita , Lazzara Giuseppe 
Published: August 2022

Abstract
In the last decades, the research in the field of cultural heritage has shifted its attention to the development of green methods, focusing on the use of renewable and biodegradable materials. Within this scenario, Agar has been one of the most innovative materials available to the conservator. However, sometimes its physical characteristics such as rigidity and gelation temperature are not always an advantage in the treatment of artwork. The atomization of hydrocolloid, a procedure presented in 2019 under the name of Agar spray, has enhanced the performance of this extraordinary material. This work aims to explore the new physical and mechanical characteristics imparted to the gel by the new spray procedure, compared to agar gel that forms under normal environmental conditions. Mechanical resistance and film transparency of both soft materials have been characterized, and the speed of water release has been detected on porous material, lateral solvent flow evaluated for confined cleaning. The new residues, potentially left by the gel after the spray application, were analyzed comparing them with the residues of the gel, which gels at room temperature. The dry Agar films were studied in terms of hydrophobicity of the dry film, agar towards water and water vapor permeability. The data that emerged from the study confirm the new features imparted to the gel by the new procedure, suggesting new measures to be taken to optimize its application.
The influence of ICT use and related attitudes on students’ math and science performance: multilevel analyses of the last decade’s PISA surveys
Authors: Courtney Matthew , Karakus Mehmet , Ersozlu Zara , Nurumov Kaidar 
Published: August 2022

AbstractThis study analyzed the latest four PISA surveys, 2009, 2012, 2015, and 2018, to explore the association between students’ ICT-related use and math and science performance. Using ICT Engagement Theory as a theoretical framework and a three-level hierarchical linear modeling approach, while controlling for confounding effects, ICT-related independent variables of interest were added to the models at the student, school, and country levels. The series of models revealed that, in general, an increase in ICT availability and ICT use both inside and outside school had a negative association with learning outcomes, while students’ positive attitude toward ICT demonstrated a strong positive relationship. However, students’ perceived autonomy related to ICT use had the strongest association with academic performance, which is consistent with the changing nature of the modern learning environments. Findings revealed that virtually all forms of student ICT use, both inside and outside of school and whether subject related or not, had no substantive positive relationship with student performance in math or science. Conversely, higher student attitude toward, confidence in, belief in utility of, and autonomous use of ICT was associated with higher math and science performance for each of the four years of the study. Incidentally, we also found that while country GDP per capita had no consistent association with student performance, a school’s provision of extra-curricula activities did. Recommendations for educational leaders, teachers, and parents are offered.
Giant splenic artery aneurysm rupture into the stomach that was successfully managed with emergency distal pancreatectomy
Authors: Yoshikawa Chihiro , Yamato Ichiro , Nakata Yasuyuki , Nakagawa Tadashi , Inoue Takashi , Nakatani Mitsuhiro , Nezu Daiki , Doi Shunsuke , Kuroda Yasuhiro , Fujii Kazuki , Kishida Shouhei , Kamikubo Midori , Ko Saiho 
Published: August 2022

Abstract
Background
Splenic artery aneurysms usually rupture into the free peritoneal space and rarely into the gastrointestinal tract. We report the case of a patient with a giant splenic artery aneurysm that ruptured in to the stomach with hemorrhagic shock and was successfully treated with emergency surgery.

Case presentation
A 59-year-old man presented to the emergency department with chest pain and syncope. Contrast-enhanced computed tomography showed splenic artery aneurysm with active contrast extravasation. He developed upper gastrointestinal (UGI) bleeding and hypovolemic shock. We diagnosed a splenic artery aneurysm ruptured in to the stomach, performed emergency distal splenopancreatectomy including the aneurysm and partial gastric resection, and could prevent patient death.

Conclusions
This report shows that splenic artery aneurysm can cause UGI bleeding. Thus, clinicians should be alert about this condition when managing patients with UGI bleeding and/or splenic artery aneurysm.
Treatment of acute aortic dissection type A with paraplegia and distal limb ischemia within a hybrid operating room
Authors: Kvalheim Venny Lise , Soknes Maria Devold , Jenssen Guttorm Lysvold , Haaverstad Rune 
Published: August 2022

Abstract
Objective
Acute aortic dissection type A is among the most lethal surgical emergencies. Patients may suffer from occlusion of the aorta or its branches causing end-organ malperfusion complicating the diagnosis and worsening the prognosis. Paraplegia is a rare manifestation that affects less than 5% of patients. If type A aortic dissection and occlusion of the downstream thoraco-abdominal aorta occur simultaneously and require acute treatment, a medical dilemma occurs; what should be treated first?

Case report
We describe a case with an extensive acute type A aortic dissection with signs of consciousness and severe malperfusion syndrome.

Results
The treatment was successfully performed within a hybrid surgery suite with simultaneous open surgery and endovascular repair techniques supported by cardiopulmonary bypass circulation.

Conclusion
A hybrid operating room might offer the opportunity to simultaneously repair complicated aortic dissection with malperfusion syndrome, by open aortic surgery and endovascular techniques.
Vestibular therapy to reduce falls in people with Alzheimer’s disease: study protocol for a pilot randomized controlled trial
Authors: Yesantharao Lekha V. , Rosenberg Paul , Oh Esther , Leoutsakos Jeannie , Munro Cynthia A. , Agrawal Yuri 
Published: August 2022

Abstract
Background
Falls are highly common in patients with Alzheimer’s disease (AD); around two-thirds of AD patients fall annually. Fall events are major drivers of injury, early institutionalization, and shorter survival. Balance and mobility impairment are among the most important fall risk factors in AD patients. Vestibular therapy (VT) is an effective rehabilitation intervention in improving balance and fall risk through vestibular function, but not often used in AD. We want to evaluate the feasibility of using VT to reduce falls and improve balance function in patients with AD and drive use of an existing, potentially beneficial therapy in a patient population whose high level of vestibular deficits is currently unaddressed.

Methods
The proposed pilot clinical trial will be a parallel-group randomized controlled trial. Patients with a diagnosis of mild-moderate AD, age ≥ 60, and the presence of a caregiver will be recruited from the Johns Hopkins Memory and Alzheimer’s Treatment Center. Eligible patients will be offered vestibular testing. Patients with vestibular loss will be offered participation in the VT trial. One-hundred AD patients with vestibular loss will be enrolled and randomized 1:1 into the control and intervention arms of the trial. All patients will undergo baseline balance and cognitive assessment, followed by 8 weeks of active control therapy or VT, consisting of ~25-min office sessions with a vestibular therapist. Patients will be tracked for falls and undergo follow-up balance and cognitive assessment at 8 and 52 weeks (1 year) to assess the potential short-term and longer-term effects, respectively, of VT on balance and cognition. The main outcomes of this trial are falls, balance (using the Berg Balance Scale and the Timed Up and Go test), and cognition (using the clock drawing test, the Card Rotations test, the Money Road Map test, and the triangle completion task).

Discussion
As the population ages and the number of individuals with AD in the US grows to a projected 14 million in 2050, managing falls in AD will continue to grow as a critical public health concern; this trial assesses feasibility of a potential solution.

Trial registration
ClinicalTrial.Gov identifier — NCT03799991. Registered 01 August 2019.
Generation gap, learning from the experience of compulsory remote architectural design studio
Authors: Iranmanesh Aminreza , Onur Zeynep 
Published: August 2022

AbstractPhysical design studio has been the mainstream method of architectural pedagogy for more than a century. Although the past two decades have brought forth emerging possibilities via advancements in digital communication, Virtual Design Studio (VDS) remained an experimental novelty until 2020. The interruption of face-to-face educational activities saw architecture schools facing a rapid paradigm shift because their studio-centred pedagogy retains intrinsic spatial qualities that are often attributed as critical dimensions of the learning process. This article explores the transition to the virtual design studio in a department of architecture after distance education became mainstream due to the global pandemic. The paper provides a comparison between students’ and lecturers’ points of view regarding different aspects of the virtual design studio. This addresses a potential generational gap concerning digital communication in a case study. A survey was administered to a group of architecture students who travelled back home and continued their education online and to the teachers of design studios who instructed VDS after the pandemic outbreak. The findings show the significant influence of effective communication, access to proper resources, maintenance of peer connections, and group works on the positive outcomes of the architectural design studio.
Quality attributes of chicken nuggets extended with different legume flours
Authors: Abiala Opeyemi , Abiala Moses , Omojola Babatunde 
Published: August 2022

AbstractChicken nugget is a comminuted meat product commonly prepared from spiced chicken meat and other ingredients. The tenderness of chicken meat lowers its firmness and mouth feel which may reduce acceptability of chicken nugget made from it. Thus, acceptability of chicken nugget could be harnessed when legume flour extenders are used along. Therefore, acceptability as well as quality of chicken nugget from different legume flours were evaluated. Soyabean, groundnut and cowpea flours were used as meat extenders for development of raw chicken nuggets and thereafter cooked for consumption. The quality of both raw and cooked legume flour extended chicken nuggets were assessed based on functional properties, sensory properties, proximate composition, amino acid content and shelf stability in terms of lipid peroxidation and microbial load. In their raw state, the legume flour extenders competed favourably with each other. Among all, soyabean flour extender maintained remarkable functional properties that transcend into significant (P < 0.05) yield of 86.93% of chicken nugget in comparison to the control (86.37%), groundnut (84.95%) and cowpea (84.50%). Upon cooking, all the legume flour extended chicken nuggets varied in their quality attributes. Apart from the high level of flavour and low microbial load, cowpea extended chicken nugget was of low quality based on the parameters evaluated in comparison with other legume flour extended chicken nuggets. Of interest, soyabean extended chicken nugget followed by groundnut extended chicken nugget were of good quality based on sensory properties, high crude protein and amino acid levels, low cholesterol content and lipid peroxidation value as well as low microbial load.Graphical abstract