bluuebunny/crossref_metadata_2025_split huggingface dataset:
MRI findings in atraumatic shoulder pain—patterns of disease correlated with age and gender
Authors: Eustace Sarah K. , Murphy Alexandra N. , Hurley Daire J. , Abul Ahmed H. Alsayegh , Kavanagh Eoin 
Published: May 2022

Abstract
Background
The rotator cuff is a group of muscles and tendons which support the shoulder joint. Rotator cuff disease is a frequent cause of morbidity in adulthood.

Aims
The aims of his study are to determine the prevalence and patterns of rotator cuff derangement in symptomatic patients using MRI and to attempt to correlate identified patterns of disease with age and gender

Methods
Five hundred ninety-seven patients attending for MRI of the shoulder with atraumatic shoulder pain were included for study. Patients’ age and gender was recorded. Record was made of the presence or absence of rotator cuff derangement and of degenerative change in the AC and glenohumeral joints. Correlation was made between age and gender.

Results
There were 358 males (60%) and 239 females (40%) with a mean age of 49.4 ± 17.1 years. Subacromial bursitis was identified in 517 patients. A normal supraspinatus tendon was identified in 219 patients and supraspinatus full thickness tearing was identified in 102 patients. A normal AC joint was identified in 267 patients while degenerative AC joint changes were identified in 370 patients. A significant correlation was identified between age and rotator cuff derangement (p < .001) and between age and AC joint derangement (p < .001). No significant difference was identified between gender and patterns of cuff derangement

Conclusion
The extent of rotator cuff and AC joint derangement increases with ageing. Impingement appears to trigger a cascade of events in sequence, from isolated subacromial bursitis through to supraspinatus tendon tearing. Patterns of rotator cuff derangement are similar in men and women.
Trace Elements and Arsenic Speciation of Field and Market Rice Samples in contrasting Agro-climatic Zones in Sri Lanka
Authors: Perera A. J. D. , Carey Manus , De Silva P. Mangala C. S. , Meharg Caroline , Meharg Andrew A. 
Published: May 2022

AbstractRice is a major source for micro-elements for the Sri Lankan population, across all agro-climatic zones. This current study was conducted to investigate the variation of the metal(loid)s and As speciation in rice grains collected from wet, intermediate and dry zones of Sri Lanka. Field rice (brown rice) and market rice (polished rice) samples were analysed for total elemental profile and As speciation using ICP-MS and IC-ICP-MS, respectively. As, Cd, Co, Fe, Mn, Mo, Rb, Se, Sr and Zn in field grain samples varied across climatic zones. Highest median Cd, Cu, Mo, P, Rb, Se and Zn from wet zone; Co, Fe, Mn from intermediate zone; and As and Sr from dry zone were reported. Field rice (As, 0.3%; Cd, 1%) and market rice (As, 0%; Cd, 3%) samples exceeded maximum permissible levels of As and Cd. However, higher concentrations of both fields, 18% samples for As and 21% samples for Cd, and market, 7% samples for As and 38% samples for Cd, rice exceeded the recommended permissible levels of As and Cd in infant food according to EU regulations. The high per capita consumption and the chronic exposure to As and Cd through rice may cause adverse effects on Sri Lankan children and adults.
De bijdrage van IkPas aan de landelijke en lokale preventieakkoorden
Authors: Bovens Rob H. L. M. , Hoevenaars Gisèle , Planken Martijn J. E. 
Published: May 2022

SamenvattingIn de IkPas-challenge zetten deelnemers gedurende een periode hun alcoholgebruik op pauze. IkPas maakt deel uit van het Nationaal Preventie Akkoord 2018 als instrument dat de bewustwording over het eigen en maatschappelijk gebruik van alcohol verhoogt. IkPas is ook een interventie die leidt tot vermindering van overmatig alcoholgebruik en ingezet kan worden door zorgprofessionals die alcoholproblematiek signaleren. Een battle tussen twee gemeenten tijdens IkPas/Dry January 2021 laat bovendien zien dat IkPas als attractieve actie een agendasetter is en de deelname van organisaties aan een lokaal alcoholpreventiebeleid kan verhogen en verstevigen.
A Decision Support System for preclinical assessment of nanomaterials in medical products: the REFINE DSS
Authors: Zabeo Alex , Rosada Fabio , Pizzol Lisa , Caputo Fanny , Borgos Sven Even , Parot Jeremie , Geertsma Robert E. , Pouw Joost Jacob , Vandebriel Rob J. , Moreno Oihane Ibarrola , Hristozov Danail 
Published: May 2022

AbstractThe application of nanomaterials in medicine has led to novel pharmaceuticals and medical devices that have demonstrated a strong potential for increasing the efficacy/performance and safety of therapeutic and diagnostic procedures to address a wide range of diseases. However, the successful translation of these technologies from their inception (proof-of-concept) to clinical practice has been challenged by substantial gaps in the scientific and technical capacity of R&D companies, especially SMEs, to keep up with the ever-evolving regulatory expectations in the emerging area of nanomedicine. To address these challenges, the EU Horizon 2020 project REFINE has developed a Decision Support System (DSS) to support developers of nanotechnology-enabled health products in bringing their products to the clinic. The REFINE DSS has been developed to support experts, innovators, and regulators in the implementation of intelligent testing strategies (ITS) for efficient preclinical assessment of nanotechnology-enabled health products. The DSS applies logical rules provided by REFINE experts which generate prioritized lists of assays to be performed (i.e. ITSs) for physicochemical characterisation and for immunotoxicological endpoints. The DSS has been tested against several case studies and was validated by internal project experts as well as external ones.
Graphical abstract
Utilizing Carbon Ions to Treat Medulloblastomas that Exhibit Chromothripsis
Authors: Schreiber Hannah Sophia , Simovic Milena , Ernst Aurélie 
Published: May 2022

Abstract

Purpose of Review

Novel radiation therapies with accelerated charged particles such as protons and carbon ions have shown encouraging results in oncology. We present recent applications as well as benefits and risks associated with their use.

Recent Findings

We discuss the use of carbon ion radiotherapy to treat a specific type of aggressive pediatric brain tumors, namely medulloblastomas with chromothripsis. Potential reasons for the resistance to conventional treatment, such as the presence of cancer stem cells with unique properties, are highlighted. Finally, advantages of particle radiation alone and in combination with other therapies to overcome resistance are featured.

Summary

Provided that future preclinical studies confirm the evidence of high effectiveness, favorable toxicity profiles, and no increased risk of secondary malignancy, carbon ion therapy may offer a promising tool in pediatric (neuro)oncology and beyond.
Grade Inflation or Grade Increase
Authors: Yeritsyan Anna , Mjelde James W. , Litzenberg Kerry K. 
Published: May 2022

AbstractAcademics worry grade inflation lowers standards; whereas, employers are concerned grades may not distinguish students’ abilities. These concerns are dismissed if higher grades reflect improved academic achievement and not inflation. Potential grade inflation is examined using data from 17,696 classes between 1985 and 2019 in the College of Agriculture and Life Sciences at Texas A&M University. Evidence of systemic grade increase is found after controlling for institution, instructor, and student characteristics. Grade increases are partially explained by recruiting better and more female students. Grade inflation, however, may be associated with increased hiring of graduate students and other instructors.
Verification framework for control theory of aircraft
Authors: Jasim O. A. , Veres S. M. 
Published: May 2022

AbstractA control system verification framework is presented for unmanned aerial vehicles using theorem proving. The framework’s aim is to set out a procedure for proving that the mathematically designed control system of the aircraft satisfies robustness requirements to ensure safe performance under varying environmental conditions. Extensive mathematical derivations, which have formerly been carried out manually, are checked for their correctness on a computer. To illustrate the procedures, a higher-order logic interactive theorem-prover and an automated theorem-prover are utilised to formally verify a nonlinear attitude control system of a generic multi-rotor UAV over a stability domain within the dynamical state space of the drone. Further benefits of the procedures are that some of the resulting methods can be implemented onboard the aircraft to detect when its controller breaches its flight envelope limits due to severe weather conditions or actuator/sensor malfunction. Such a detection procedure can be used to advise the remote pilot, or an onboard intelligent agent, to decide on some alterations of the planned flight path or to perform emergency landing.
Moving beyond annual data reports: A blueprint for communicating and disseminating actionable intelligence
Authors: Ruiz Raquel , Schwartz Ann , Orlando Elissa , Ossip Deborah , Zand Martin S. , Dozier Ann 
Published: May 2022

Abstract
Identifying and disseminating actionable intelligence is a challenging task that requires thoughtful planning. The National Center for Advancing Translational Sciences instituted the Common Metrics Initiative with the goal of evaluating the Clinical and Translational Science Awards (CTSA) Programs using a standard set of metrics. Initially managed by Tufts University, the Center for Leading Innovation and Collaboration (CLIC) at the University of Rochester began leading this initiative in 2017. In directing this work, CLIC created a framework for communicating and disseminating data insights. Insights to Inspire emerged from the need to share strategies and lessons learned to improve metric performance at the local level to a network of 60+ academic research institutions. Insights to Inspire employs a mixed methods approach for translating data into actionable intelligence. A series of blogs, webinars, and webcasts were designed to communicate metric-specific strategies used by individual sites to the broader CTSA consortium. A dissemination plan to expand the reach beyond metric stakeholders utilized focused communications including social media channels, network newsletters, and presentations at national meetings. This framework serves as a blueprint for other national evaluation programs interested in a systematic approach to using data insights for continuous improvement.
The Lottery Paradox, the No-Justification Account, and Taiwan
Authors: Lee Kok Yong 
Published: May 2022

AbstractTo resolve the lottery paradox, the “no-justification account” proposes that one is not justified in believing that one's lottery ticket is a loser. The no-justification account commits to what I call “the Harman-style skepticism”. In reply, proponents of the no-justification account typically downplay the Harman-style skepticism. In this paper, I argue that the no-justification reply to the Harman-style skepticism is untenable. Moreover, I argue that the no-justification account is epistemically ad hoc. My arguments are based on a rather surprising finding that the no-justification account implies that people living in Taiwan typically suffer from the Harman-style skepticism.
Aspectual Verb Constructions in Persian
Authors: Rasekh-Mahand Mohammad , Parizadeh Mehdi 
Published: May 2022

AbstractThis paper aims to describe and explain the different morphosyntactic and semantic features of some double verb constructions in Persian, an Indo-European language mainly spoken in Iran. It is argued that these double verb constructions are not instances of serial verb construction, but instances of emerging aspectual verbs with varied degrees of grammaticalization. It is argued that numerous factors lead to grammaticalization of these verbs, including context, the semantic class of the verbs, and their frequency. A corpus-based analysis shows that these aspectual verbs have been grammaticalized in different ratios during the last one hundred years, demonstrating ongoing change in the Persian language.
Dietary diversity score (DDS) and odds of colorectal cancer and adenoma: a case–control study
Authors: Bahrami Alireza , Shirani Pedram , Sohouli Mohammadhassan , Nasab Saeede Jaafari , Rafiee Pegah , Naja Farah , Sheikhimobarakeh Zahra , Hejazi Ehsan 
Published: May 2022

Abstract
Despite mounting evidence that dietary factors might have a protective role against risk of cancer, few studies have assessed the relationship between diet diversity with colorectal cancer (CRC) and colorectal adenoma (CRA). Thus, we examined the relationship between dietary diversity score (DDS) and the odds of CRC and CRA. Overall, 129 CRC diagnosed patients, 130 CRA diagnosed cases and 240 healthy hospitalised controls were studied. DDS was calculated based on information on the usual diet that was assessed by a valid and reliable food frequency questionnaire (FFQ). Multivariate logistic regression was used to estimate the relationship between DDS and odds of colorectal cancer and adenoma. After adjusting for potential confounders, the diversity of grains is associated with the increased odds of CRC (ORgrains: 2·96 (1·05–8·32); P = 0·032), while the diversity of vegetables and fruits are associated with decreased odds of CRC (ORvegetables: 0·31 (0·16–0·62); P = 0·001, ORfruits: 0·37 (0·23–0·61); P < 0·001). The diversity of vegetables, fruits and dairy are inversely associated with odds of CRA (ORvegetables: 0·41 (0·21–0·78); P = 0·007, ORfruits: 0·58 (0·36–0·93); P = 0·021, ORdairies: 0·56 (0·37–0·83); P = 0·004). Also, higher DDS was related to decreased odds of both CRC (OR: 0·41 (0·23–0·72); P for trend = 0·002) and CRA (OR: 0·36 (0·21–0·65); P for trend = 0·001). Our results indicated that higher dietary diversity and particularly a diet varied in fruits and vegetables may reduce the odds of CRC and CRA. Also, the consumption of dairy products may decrease the odds of CRC, whereas the consumption of grains may increase the odds of CRC.
Morphology and paleobiology of the Late Cretaceous large-sized sharkCretodus crassidens(Dixon, 1850) (Neoselachii; Lamniformes)
Authors: Amalfitano Jacopo , Dalla Vecchia Fabio Marco , Carnevale Giorgio , Fornaciari Eliana , Roghi Guido , Giusberti Luca 
Published: May 2022

AbstractThe definition of the Cretaceous shark genusCretodusSokolov, 1965 is primarily based on isolated teeth. This genus includes five species. Among these,Cretodus houghtonorumShimada and Everhart, 2019 is the only species based on a partially preserved skeleton. Here, the taxonomic attribution of a virtually complete skeleton ofCretodusfrom the Turonian of northeastern Italy is discussed, together with a few specimens from the Turonian of England. One of the latter is investigated through micropaleontological analysis to determine its stratigraphic position. The material is referred toCretodus crassidens(Dixon, 1850), the diagnosis of which is emended herein. The dentition is tentatively reconstructed, exhibiting strong similarities with congeneric species, although it differs in having strong vertical folds on the main cusp labial face, a mesiodistally broad tooth aspect, weak and well-spaced ‘costulae’ at crown base, and a different dental formula in the number of parasymphyseal and lateral rows. Some tooth malformations are interpreted as feeding-related or senile characters. The Italian specimen suggests thatCretodus crassidenshad a wide and laterally expanded mouth and head, a stout body, and attained a gigantic size.Cretodus crassidenswas a moderate-speed swimming shark ecologically like the extant tiger sharkGaleocerdo cuvier(Péron and Lesueur in Lesueur, 1822). The age estimate from vertebral-band counting suggests that the Italian individual was at least 23 years old and the growth model indicates a longevity of 64 years and a maximum attainable total length of 9–11 m.Cretodus crassidensoccurs both in Boreal and Tethyan domains, implying a broad paleobiogeographic distribution and a preference toward offshore settings.
The last representatives of the Superfamily Wellerelloidea (Brachiopoda, Rhynchonellida) in the westernmost Tethys (Iberian paleomargins) prior to their demise in the early Toarcian Mass Extinction Event
Authors: Baeza-Carratalá José Francisco , García Joral Fernando 
Published: May 2022

AbstractThe last clade-level extinction episode affecting the Phylum Brachiopoda has been long-established in the Early Toarcian Mass Extinction Event (ETMEE) around the Pliensbachian-Toarcian transition, when several rhynchonellide groups became extinct and others underwent a notable renewal in the western Tethys. Among them, Wellerelloidea is a long-ranging superfamily severely affected by this environmental crisis, embodying the subfamily Cirpinae as the last wellerelloids worldwide, prior to their global extinction in the Pb-To transition. The profuse record of Lower Jurassic cirpines in the peri-Iberian paleomargins provides an opportunity to clarify the taxonomy of wellerelloid species in the pre-extinction interval. A new species (Cirpa lucentina) is erected and the revision of the Cirpinae taxa around the ETMEE is carried out. Morphometric analysis and the study of internal structures of the shells support separation of the genera Cirpa and Salgirella, adding new supplementary diagnostic criteria. The biogeographic distribution of this clade in the western Tethys and its evolutionary history in the Early Jurassic reveal a pervasive colonization pattern of both epicontinental and epioceanic habitats. The Mediterranean origin of the last representatives of this group is ascertained, but while diversification of Salgirella took place in epioceanic habitats, speciation of Cirpa is unrelated to biochorema boundaries, even colonizing epicontinental seas until their extinction prior to the hyperwarming event that occurred in the basal Serpentinum Zone. A rhynchonellide morphogroup epitomized by cirpines was resilient to this event in the epicontinental seas. This morphogroup is also recorded after the extinction interval by means of the genus Pseudogibbirhynchia, thus postulating potential pre- and post-extinction phyletic relationships.UUID: http://zoobank.org/100b06c0-a803-4f6f-b0fa-2d9e2d6678d2
Associations of dietary and lifestyle inflammation scores with mortality due to CVD, cancer, and all causes among Black and White American men and women
Authors: Troeschel Alyssa N. , Byrd Doratha A. , Judd Suzanne , Flanders W. Dana , Bostick Roberd M. 
Published: May 2022

AbstractOne potential mechanism by which diet and lifestyle may affect chronic disease risk and subsequent mortality is through chronic systemic inflammation. In this study, we investigated whether the inflammatory potentials of diet and lifestyle, separately and combined, were associated with all-cause, all-CVD and all-cancer mortality risk. We analysed data on 18 484 (of whom 4103 died during follow-up) Black and White men and women aged ≥45 years from the prospective REasons for Geographic and Racial Differences in Stroke study. Using baseline (2003–2007) Block 98 FFQ and lifestyle questionnaire data, we constructed the previously validated inflammation biomarker panel-weighted, 19-component dietary inflammation score (DIS) and 4-component lifestyle inflammation score (LIS) to reflect the overall inflammatory potential of diet and lifestyle. From multivariable Cox proportional hazards models, the hazards ratios (HR) and their 95 % CI for the DIS–all-cause mortality and LIS–all-cause mortality risk associations were 1·32 (95 % CI (1·18, 1·47);Pfor trend< 0·01) and 1·25 (95 % CI (1·12, 1·38);Pfor trend< 0·01), respectively, among those in the highest relative to the lowest quintiles. The findings were similar by sex and race and for all-cancer mortality, but weaker for all-CVD mortality. The joint HR for all-cause mortality among those in the highest relative to the lowest quintiles of both the DIS and LIS was 1·91 (95 % CI 1·57, 2·33) (Pfor interaction< 0·01). Diet and lifestyle, via their contributions to systemic inflammation, separately, but perhaps especially jointly, may be associated with higher mortality risk among men and women.
The role of fingernail selenium in the association between arsenic, lead and mercury and child development in rural Vietnam: a cross-sectional analysis
Authors: Egwunye Jacob , Cardoso Barbara R. , Braat Sabine , Ha Tran , Hanieh Sarah , Hare Dominic , Duan Alex Xiaofei , Doronila Augustine , Tran Thach , Tuan Tran , Fisher Jane , Biggs Beverley-Ann 
Published: May 2022

AbstractAs, Pb and Hg are common environmental contaminants in low- and middle-income countries. We investigated the association between child toxicant exposure and growth and development and determined if this association was mitigated by Se concentration. Toxicant concentrations in fingernail samples, anthropometry and Bayley’s Scales of Infant Development, 3rd edition domains were assessed in 36-month-old children whose mothers had been part of a randomised controlled trial in rural Vietnam. Multivariable regression analyses were performed to estimate the effect of toxicant exposure on clinical outcomes with adjustments for potential confounders and interaction with fingernail Se concentration. We analysed 658 children who had data for at least one physical or developmental outcome, and at least one toxicant measurement, and each of the covariates. Fingernail As concentration was negatively associated with language (estimate per 10 % increase in As: −0·19, 95 % CI: (–0·32, −0·05)). Pb was negatively associated with cognition (estimate per 10 % increase in Pb: −0·08 (–0·15, −0·02)), language (estimate per 10 % increase in Pb: −0·18 (–0·28, −0·10)) and motor skills (estimate per 10 % increase in Pb: −0·12 (–0·24, 0·00)). Hg was negatively associated with cognition (estimate per 10 % increase in Hg: −0·48, (–0·72, −0·23)) and language (estimate per 10 % increase in Hg −0·51, (–0·88, −0·13)) when Se concentration was set at zero in the model. As Se concentration increased, the negative associations between Hg and both cognition and language scores were attenuated. There was no association between toxicant concentration and growth. As, Pb and Hg concentrations in fingernails of 3-year-old children were associated with lower child development scores. The negative association between Hg and neurological development was reduced in magnitude with increasing Se concentration. Se status should be considered when assessing heavy metal toxicants in children and their impact on neurodevelopmental outcomes.