bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Kinetic Theory of Subauroral Arcs
Authors: Mishin Evgeny , Streltsov Anatoly 
Published: August 2022

AbstractWe report on a novel scenario of subauroral arcs within strong subauroral ion drifts (SAID)‐STEVE and Picket Fence. Their explanation requires a local source of low‐energy, ε < 18.75 eV, suprathermal electrons, and N2 vibrational and electronic excitation below ∼270 km. We show that the ionospheric feedback instability in strong SAID flows with depleted density troughs generates intense, small‐scale field‐aligned currents and parallel electric fields below the F2 peak. With these fields, we employed a rigorous numerical solution of the Boltzmann kinetic equation for the distribution of ionospheric electrons and determined the power going to excitation and ionization of neutral gas (the energy balance). The obtained suprathermal electron population and energy balance at altitudes of ∼130–140 km are just what is necessary for Picket Fence. Concerning STEVE, the kinetic theory predictions are in a good qualitative agreement with its basic features, such as the enhanced continuum emissions. Besides, the theory predicts that subauroral arcs might have the transient phase with typical aurora‐like emissions that fade out afterward.
Three‐Dimensional Configuration of Induced Magnetic Fields Around Mars
Authors: Zhang Chi , Rong Zhaojin , Klinger Lucy , Nilsson Hans , Shi Zhen , He Fei , Gao Jiawei , Li Xinzhou , Futaana Yoshifumi , Ramstad Robin , Wang Xiaodong , Holmström Mats , Barabash Stas , Fan Kai , Wei Yong 
Published: August 2022

AbstractUsing over 6 years of magnetic field data (October 2014–December 2020) collected by the Mars Atmosphere and Volatile EvolutioN, we conduct a statistical study on the three‐dimensional average magnetic field structure around Mars. We find that this magnetic field structure conforms to the pattern typical of an induced magnetosphere, that is, the interplanetary magnetic field (IMF) which is carried by the solar wind and which drapes, piles up, slips around the planet, and eventually forms a tail in the wake. The draped field lines from both hemispheres along the direction of the solar wind electric field (E) are directed toward the nightside magnetic equatorial plane, indicating that they are “sinking” toward the wake. These “sinking” field lines from the +E‐hemisphere (E pointing away from the plane) are more flared and dominant in the tail, while the field lines from the –E‐hemisphere (E pointing toward) are more stretched and “pinched” toward the plasma sheet. Such highly “pinched” field lines even form a loop over the pole of the –E‐hemisphere. The tail current sheet also shows an E‐asymmetry: the sheet is thicker with a stronger tailward force at +E‐flank, but much thinner and with a weaker (even turns sunward) at –E‐flank. Additionally, we find that IMF Bx can induce a kink‐like field structure at the boundary layer; the field strength is globally enhanced and the field lines flare less during high dynamic pressure.
Synthesis and Stability of an Eight‐Coordinated Fe3O4 High‐Pressure Phase: Implications for the Mantle Structure of Super‐Earths
Authors: Zurkowski C. C. , Yang J. , Chariton S. , Prakapenka V. B. , Fei Y. 
Published: August 2022

AbstractSuper‐Earths ranging up to 10 Earth masses (ME) with Earth‐like density are common among the observed exoplanets thus far, but their measured masses and radii do not uniquely elucidate their internal structure. Exploring the phase transitions in the Mg‐silicates that define the mantle‐structure of super‐Earths is critical to characterizing their interiors, yet the relevant terapascal conditions are experimentally challenging for direct structural analysis. Here we investigated the crystal chemistry of Fe3O4 as a low‐pressure analog to Mg2SiO4 between 45–115 GPa and up to 3000 K using powder and single crystal X‐ray diffraction in the laser‐heated diamond anvil cell. Between 60–115 GPa and above 2000 K, Fe3O4 adopts an 8‐fold coordinated Th3P4‐type structure (I‐43d, Z = 4) with disordered Fe2+ and Fe3+ into one metal site. This Fe‐oxide phase is isostructural with that predicted for Mg2SiO4 above 500 GPa in super‐Earth mantles and suggests that Mg2SiO4 can incorporate both ferric and ferrous iron at these conditions. The pressure‐volume behavior observed in this 8‐fold coordinated Fe3O4 indicates a maximum 4% density increase across the 6‐ to 8‐fold coordination transition in the analog Mg‐silicate. Reassessment of the FeO—Fe3O4 fugacity buffer considering the Fe3O4 phase relationships identified in this study reveals that increasing pressure and temperature to 120 GPa and 3000 K in Earth and planetary mantles drives iron toward oxidation.
Ubap1 knock-in mice reproduced the phenotype of SPG80
Authors: Shimozono Keisuke , Nan Haitian , Hata Takanori , Saito Kozo , Kim Yeon-Jeong , Nagatomo Hiroaki , Ohtsuka Toshihisa , Koizumi Schuichi , Takiyama Yoshihisa 
Published: August 2022

AbstractSPG80 is a neurodegenerative disorder characterized by a pure type of juvenile-onset hereditary spastic paraplegia and is caused by a heterozygous mutation of the UBAP1 (ubiquitin-associated protein 1) gene. UBAP1 is one of the subunits of the endosomal sorting complex required for transport I and plays a role in endosome sorting by binding to ubiquitin-tagged proteins. In this study, we generated novel Ubap1+/E176Efx23 knock-in mice, in which the SOUBA domain of Ubap1 was completely deleted with the UMA domain being intact, as an animal model of SPG80. The knock-in mice with this heterozygous Ubap1 truncated mutation appeared normal at birth, but they developed progressive hind limb dysfunction several months later. Molecular pathologically, loss of neurons in the spinal cord and accumulation of ubiquitinated proteins were observed in Ubap1+/E176Efx23 knock-in mice. In addition, changes in the distributions of Rab5 and Rab7 in the spinal cord suggest that this mutation in Ubap1 disturbs endosome-mediated vesicular trafficking. This is the first report of a mouse model that reproduces the phenotype of SPG80. Our knock-in mice may provide a clue for understanding the molecular pathogenesis underlying UBAP1-related HSP and screening of therapeutic agents.
Frequency comb-to-comb stabilization over a 1.3-km free-space atmospheric optical link
Authors: Yang Jaewon , IL Lee Dong , Shin Dong-Chel , Lee Jaehyun , Kim Byung Soo , Kang Hyun Jay , Kim Young-Jin , Kim Seung-Woo 
Published: August 2022

AbstractStabilizing a frequency comb to an ultra-stable optical frequency reference requires a multitude of optoelectronic peripherals that have to operate under strict ambient control. Meanwhile, the frequency comb-to-comb stabilization aims to synchronize a slave comb to a well-established master comb with a substantial saving in required equipment and efforts. Here, we report an utmost case of frequency comb-to-comb stabilization made through a 1.3 km free-space optical (FSO) link by coherent transfer of two separate comb lines along with a feedback suppression control of atmospheric phase noise. The FSO link offers a transfer stability of 1.7 × 10–15 at 0.1 s averaging, while transporting the master comb’s stability of 1.2 × 10–15 at 1.0 s over the entire spectrum of the slave comb. Our remote comb-to-comb stabilization is intended to expedite diverse long-distance ground-to-ground or ground-to-satellite applications; as demonstrated here for broadband molecular spectroscopy over a 6 THz bandwidth as well as ultra-stable microwaves generation with phase noise of -80 dBc Hz–1 at 1 Hz.
An excellent deep-ultraviolet birefringent material based on [BO2]∞ infinite chains
Authors: Zhang Fangfang , Chen Xinglong , Zhang Min , Jin Wenqi , Han Shujuan , Yang Zhihua , Pan Shilie 
Published: August 2022

AbstractBirefringent materials play indispensable roles in modulating the polarization of light and are vital in the laser science and technology. Currently, the design of birefringent materials operating in the deep-ultraviolet region (DUV, λ ≤200 nm) is still a great challenge. In this work, we developed a new DUV birefringent crystal LiBO2 based on [BO2]∞ infinite chains in the Li-B-O system, which simultaneously achieves the shortest UV cutoff edge (164 nm) and the largest birefringence (≥0.168 at 266 nm) among all the reported borate-based DUV birefringent materials. Single crystals of LiBO2 with dimensions up to Ø55 × 34 mm3 were grown by the Czochralski method, providing access to large-sized single crystal with low cost. Moreover, it has a high laser damage threshold and stable physicochemical properties. These outstanding characters unambiguously support that LiBO2 can be an excellent birefringent material for DUV application.
Time in schizophrenia: a link between psychopathology, psychophysics and technology
Authors: Amadeo Maria Bianca , Esposito Davide , Escelsior Andrea , Campus Claudio , Inuggi Alberto , Pereira Da Silva Beatriz , Serafini Gianluca , Amore Mario , Gori Monica 
Published: August 2022

AbstractIt has been widely demonstrated that time processing is altered in patients with schizophrenia. This perspective review delves into such temporal deficit and highlights its link to low-level sensory alterations, which are often overlooked in rehabilitation protocols for psychosis. However, if temporal impairment at the sensory level is inherent to the disease, new interventions should focus on this dimension. Beyond more traditional types of intervention, here we review the most recent digital technologies for rehabilitation and the most promising ones for sensory training. The overall aim is to synthesise existing literature on time in schizophrenia linking psychopathology, psychophysics, and technology to help future developments.
miR-596-3p suppresses brain metastasis of non-small cell lung cancer by modulating YAP1 and IL-8
Authors: Li Chenlong , Zheng Hongshan , Xiong Jinsheng , Huang Yuxin , Li Haoyang , Jin Hua , Ai Siqi , Wang Yingjie , Su Tianqi , Sun Guiyin , Xiao Xu , Fu Tianjiao , Wang Yujie , Gao Xin , Liang Peng 
Published: August 2022

AbstractBrain metastasis (BM) frequently occurs in advanced non-small cell lung cancer (NSCLC) and is associated with poor clinical prognosis. Due to the location of metastatic lesions, the surgical resection is limited and the chemotherapy is ineffective because of the existence of the blood brain barrier (BBB). Therefore, it is essential to enhance our understanding about the underlying mechanisms associated with brain metastasis in NSCLC. In the present study, we explored the RNA-Seq data of brain metastasis cells from the GEO database, and extracted RNA collected from primary NSCLC tumors as well as paired brain metastatic lesions followed by microRNA PCR array. Meanwhile, we improved the in vivo model and constructed a cancer stem cell-derived transplantation model of brain metastasis in mice. Our data indicated that the level of miR-596-3p is high in primary NSCLC tumors, but significantly downregulated in the brain metastatic lesion. The prediction target of microRNA suggested that miR-596-3p was considered to modulate two genes essential in the brain invasion process, YAP1 and IL-8 that restrain the invasion of cancer cells and permeability of BBB, respectively. Moreover, in vivo experiments suggested that our model mimics the clinical aspect of NSCLC and improves the success ratio of brain metastasis model. The results demonstrated that miR-596-3p significantly inhibited the capacity of NSCLC cells to metastasize to the brain. Furthermore, these finding elucidated that miR-596-3p exerts a critical role in brain metastasis of NSCLC by modulating the YAP1-IL8 network, and this miRNA axis may provide a potential therapeutic strategy for brain metastasis.
Identification of a BRAF/PA28γ/MEK1 signaling axis and its role in epithelial-mesenchymal transition in oral submucous fibrosis
Authors: Xie Changqing , Li Zaiye , Hua Yufei , Sun Silu , Zhong Liang , Chen Qian , Feng Hui , Ji Ning , Li Taiwen , Zhou Xikun , Zeng Xin , Tang Zhangui , Sun Chongkui , Li Jing , Chen Qianming 
Published: August 2022

AbstractOral submucous fibrosis (OSF) is a chronic and insidious oral potentially malignant disorder associated with a 4–17% risk of oral squamous cell carcinoma (OSCC). Our previous study found that proteasomal activator 28 gamma (PA28γ) is frequently overexpressed in oral squamous cell carcinoma and negatively correlated with poor patient prognosis. However, the role of PA28γ in the occurrence and development of OSF remains unclear. Here, we screened PA28γ-related genes and investigated their function in OSF. We demonstrated that the expression of PA28γ was positively associated with MEK1 and gradually elevated from normal to progressive stages of OSF tissue. Arecoline, a pathogenic component of OSF, could upregulate the protein levels of PA28γ and phosphorylated MEK1 and contribute to epithelial to mesenchymal transition (EMT) in epithelial cells. Notably, PA28γ could interact with MEK1 and upregulate its phosphorylation level. Furthermore, arecoline upregulated BRAF, which can interact with PA28γ and upregulate its protein level. Additionally, BRAF, PA28γ, and MEK1 could form protein complexes and then enhance the MEK1/ERK signaling pathways. The concrete mechanism of the protein stability of PA28γ is that BRAF mediates its degradation by inhibiting its ubiquitination. These findings underscore the instrumental role of PA28γ in the BRAF/MEK1 pathway and enhanced EMT through MEK1/ERK activation in OSF.
CNT-molecule-CNT (1D-0D-1D) van der Waals integration ferroelectric memory with 1-nm2 junction area
Authors: Phan Thanh Luan , Seo Sohyeon , Cho Yunhee , An Vu Quoc , Lee Young Hee , Duong Dinh Loc , Lee Hyoyoung , Yu Woo Jong 
Published: August 2022

AbstractThe device’s integration of molecular electronics is limited regarding the large-scale fabrication of gap electrodes on a molecular scale. The van der Waals integration (vdWI) of a vertically aligned molecular layer (0D) with 2D or 3D electrodes indicates the possibility of device’s integration; however, the active junction area of 0D-2D and 0D-3D vdWIs remains at a microscale size. Here, we introduce the robust fabrication of a vertical 1D-0D-1D vdWI device with the ultra-small junction area of 1 nm2 achieved by cross-stacking top carbon nanotubes (CNTs) on molecularly assembled bottom CNTs. 1D-0D-1D vdWI memories are demonstrated through ferroelectric switching of azobenzene molecules owing to the cis-trans transformation combined with the permanent dipole moment of the end-tail -CF3 group. In this work, our 1D-0D-1D vdWI memory exhibits a retention performance above 2000 s, over 300 cycles with an on/off ratio of approximately 105 and record current density (3.4 × 108 A/cm2), which is 100 times higher than previous study through the smallest junction area achieved in a vdWI. The simple stacking of aligned CNTs (4 × 4) allows integration of memory arrays (16 junctions) with high device operational yield (100%), offering integration guidelines for future molecular electronics.
Direct observation of ideal electromagnetic fluids
Authors: Li Hao , Zhou Ziheng , Sun Wangyu , Lobet Michaël , Engheta Nader , Liberal Iñigo , Li Yue 
Published: August 2022

AbstractNear-zero-index (NZI) media have been theoretically identified as media where electromagnetic radiations behave like ideal electromagnetic fluids. Within NZI media, the electromagnetic power flow obeys equations similar to those of motion for the velocity field in an ideal fluid, so that optical turbulence is intrinsically inhibited. Here, we experimentally observe the electromagnetic power flow distribution of such an ideal electromagnetic fluid propagating within a cutoff waveguide by a semi-analytical reconstruction technique. This technique provides direct proof of the inhibition of electromagnetic vorticity at the NZI frequency, even in the presence of complex obstacles and topological changes in the waveguide. Phase uniformity and spatially-static field distributions, essential characteristics of NZI materials, are also observed. Measurement of the same structure outside the NZI frequency range reveals existence of vortices in the power flow, as expected for conventional optical systems. Therefore, our results provide an important step forward in the development of ideal electromagnetic fluids, and introduce a tool to explore the subwavelength behavior of NZI media including fully vectorial and phase information.
Dynamic magnetic crossover at the origin of the hidden-order in van der Waals antiferromagnet CrSBr
Authors: López-Paz Sara A. , Guguchia Zurab , Pomjakushin Vladimir Y. , Witteveen Catherine , Cervellino Antonio , Luetkens Hubertus , Casati Nicola , Morpurgo Alberto F. , von Rohr Fabian O. 
Published: August 2022

AbstractThe van-der-Waals material CrSBr stands out as a promising two-dimensional magnet. Here, we report on its detailed magnetic and structural characteristics. We evidence that it undergoes a transition to an A-type antiferromagnetic state below TN ≈ 140 K with a pronounced two-dimensional character, preceded by ferromagnetic correlations within the monolayers. Furthermore, we unravel the low-temperature hidden-order within the long-range magnetically-ordered state. We find that it is associated to a slowing down of the magnetic fluctuations, accompanied by a continuous reorientation of the internal field. These take place upon cooling below Ts ≈ 100 K, until a spin freezing process occurs at T* ≈ 40 K. We argue this complex behavior to reflect a crossover driven by the in-plane uniaxial anisotropy, which is ultimately caused by its mixed-anion character. Our findings reinforce CrSBr as an important candidate for devices in the emergent field of two-dimensional magnetic materials.
Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma
Authors: Zhang Shaofang , Li Yonghui , Sun Si , Liu Ling , Mu Xiaoyu , Liu Shuhu , Jiao Menglu , Chen Xinzhu , Chen Ke , Ma Huizhen , Li Tuo , Liu Xiaoyu , Wang Hao , Zhang Jianning , Yang Jiang , Zhang Xiao-Dong 
Published: August 2022

AbstractRegenerable nanozymes with high catalytic stability and sustainability are promising substitutes for naturally-occurring enzymes but are limited by insufficient and non-selective catalytic activities. Herein, we developed single-atom nanozymes of RhN4, VN4, and Fe-Cu-N6 with catalytic activities surpassing natural enzymes. Notably, Rh/VN4 preferably forms an Rh/V-O-N4 active center to decrease reaction energy barriers and mediates a “two-sided oxygen-linked” reaction path, showing 4 and 5-fold higher affinities in peroxidase-like activity than the FeN4 and natural horseradish peroxidase. Furthermore, RhN4 presents a 20-fold improved affinity in the catalase-like activity compared to the natural catalase; Fe-Cu-N6 displays selectivity towards the superoxide dismutase-like activity; VN4 favors a 7-fold higher glutathione peroxidase-like activity than the natural glutathione peroxidase. Bioactive sutures with Rh/VN4 show recyclable catalytic features without apparent decay in 1 month and accelerate the scalp healing from brain trauma by promoting the vascular endothelial growth factor, regulating the immune cells like macrophages, and diminishing inflammation.
High activity and selectivity of single palladium atom for oxygen hydrogenation to H2O2
Authors: Yu Shiming , Cheng Xing , Wang Yueshuai , Xiao Bo , Xing Yiran , Ren Jun , Lu Yue , Li Hongyi , Zhuang Chunqiang , Chen Ge 
Published: August 2022

AbstractNanosized palladium (Pd)-based catalysts are widely used in the direct hydrogen peroxide (H2O2) synthesis from H2 and O2, while its selectivity and yield remain inferior because of the O-O bond cleavage from both the reactant O2 and the produced H2O2, which is assumed to have originated from various O2 adsorption configurations on the Pd nanoparticles. Herein, single Pd atom catalyst with high activity and selectivity is reported. Density functional theory calculations certify that the O-O bond breaking is significantly inhibited on the single Pd atom and the O2 is easier to be activated to form *OOH, which is a key intermediate for H2O2 synthesis; in addition, H2O2 degradation is shut down. Here, we show single Pd atom catalyst displays a remarkable H2O2 yield of 115 mol/gPd/h and H2O2 selectivity higher than 99%; while the concentration of H2O2 reaches 1.07 wt.% in a batch.
Control of non-REM sleep by ventrolateral medulla glutamatergic neurons projecting to the preoptic area
Authors: Teng Sasa , Zhen Fenghua , Wang Li , Schalchli Jose Canovas , Simko Jane , Chen Xinyue , Jin Hao , Makinson Christopher D. , Peng Yueqing 
Published: August 2022

AbstractUnderstanding the neural mechanisms underlying sleep state transitions is a fundamental goal of neurobiology and important for the development of new treatments for insomnia and other sleep disorders. Yet, brain circuits controlling this process remain poorly understood. Here we identify a population of sleep-active glutamatergic neurons in the ventrolateral medulla (VLM) that project to the preoptic area (POA), a prominent sleep-promoting region, in mice. Microendoscopic calcium imaging demonstrate that these VLM glutamatergic neurons display increased activity during the transitions from wakefulness to Non-Rapid Eye Movement (NREM) sleep. Chemogenetic silencing of POA-projecting VLM neurons suppresses NREM sleep, whereas chemogenetic activation of these neurons promotes NREM sleep. Moreover, we show that optogenetic activation of VLM glutamatergic neurons or their projections in the POA initiates NREM sleep in awake mice. Together, our findings uncover an excitatory brainstem-hypothalamic circuit that controls the wake-sleep transitions.
Excitation energy mediated cross-relaxation for tunable upconversion luminescence from a single lanthanide ion
Authors: Fu Xiao , Fu Shuai , Lu Qi , Zhang Jing , Wan Pingping , Liu Jinliang , Zhang Yong , Chen Chia-Hung , Li Wei , Wang Huadong , Mei Qingsong 
Published: August 2022

AbstractPrecise control of energy migration between sensitizer ions and activator ions in lanthanide-doped upconversion nanoparticles (UCNPs) nowadays has been extensively investigated to achieve efficient photon upconversion. However, these UCNPs generally emit blue, green or red light only under fixed excitation conditions. In this work, regulation of the photon transition process between different energy levels of a single activator ion to obtain tunable upconversion fluorescence under different excitation conditions is achieved by introducing a modulator ion. The cross-relaxation process between modulator ion and activator ion can be controlled to generate tunable luminescence from the same lanthanide activator ion under excitation at different wavelengths or with different laser power density and pulse frequency. This strategy has been tested and proven effective in two different nanocrystal systems and its usefulness has been demonstrated for high-level optical encryption.