bluuebunny/crossref_metadata_2025_split huggingface dataset:
Українська військово-економічна ядерна бомба вже розірвалася у економіці Росії (ретроспектива, дійсне та майбутнє)
Authors: Semenenko Oleh , Dobrovolskyi Yuzef , Yarmolchyk Maria , Rakhmanyi Oleksandr , Tarasov Oleh , Remez Artem 
Published: March 2022

Мета роботи: розкрити ретроспективу підготовки Росії до війни з Україною, визначити основні воєнно-економічні особливості та наслідки впливу російсько-української війни на економіку Росії, сформувати можливі прогнозовані варіанти стану економіки Росії від розвитку сценаріїв та тривалості ведення бойових дій між Росією та Україною.
Дизайн/Метод/Підхід дослідження: основними методами досліджень є методи статистичного аналізу, воєнно-економічного аналізу, експертного опитування та методи прогнозування.
Результати дослідження: проведено аналіз динаміки стану економіки Росії до початку російсько-української війни, визначено вплив введених санкцій проти Росії на її економіку сьогодні та зроблено прогнозування стану рецесії економіки Росії за різних варіантів розвитку воєнних дій та їх тривалості, а також сформовано можливі воєнно-економічні ризики для Росії у подальшому.
Теоретична цінність дослідження: Основним результатом досліджень за тематикою статті є формування бази вихідних даних щодо наслідків дії української воєнно-економічної бомби на економіку Росії з урахуванням аналітичних ретроспективних результатів участі Росії у попередніх війнах та збройних конфліктах.
Тип статті: описовий та розрахунково-аналітичний.
PENGARUH PEMBELAJARAN DARING TERHADAP STRES PADA MAHASISWA FARMASI
Authors: Suryawati Ayu Widya , Monica Eva , Tambun Sabrina Handayani 
Published: March 2022

Pada akhir tahun 2019, dimulai munculnya virus yang diduga berasal dari Wuhan, China yaitu Covid-19. Virus ini dapat menyebar dari individu satu dengan individu yang lain. Setelah beberapa waktu lalu, penyebaran hingga terjadi di beberapa negara termasuk Indonesia, hingga WHO mengumumkan Covid-19 sebagai pandemi, untuk mencegah penyebarannya maka kegiatan akademis di Indonesia dialihkan menjadi metode pembelajaran jarak jauh atau dalam jaringan (daring). Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pembelajaran daring terhadap stres pada mahasiswa farmasi.
Jenis penelitian ini adalah kuantitatif dengan pendekatan cross sectional, cara pengambilan data adalah dengan cara menyebarkan kuesioner secara online yaitu melalui google form kepada 100 responden. Kemudian dianalisis dengan uji Chi Square dan uji Rank Spearman. Hasil dari penelitian ini adalah responden yang menilai bahwa pembelajaran daring tidak efektif dengan tingkat stres ringan adalah sebanyak 29 responden (69.0%) dan tingkat stres sedang adalah sebanyak 13 responden (31.0%), sedangkan responden yang menilai pembelajaran daring efektif dengan tingkat stres ringan adalah sebanyak 42 responden (72.4%) dan tingkat stres sedang adalah sebanyak 16 responden (27.6%). Hasil dapat disimpulkan bahwa dari 100 responden, responden cenderung berada pada tingkat stres ringan dan sebagian besar mahasiswa menganggap pembelajaran daring efektif untuk dilakukan.
PENGARUH PEMBERIAN EDUKASI TERHADAP TINGKAT PENGETAHUAN PERILAKU HIDUP BERSIH DAN SEHAT PHBS DAN PROTOKOL KESEHATAN PADA WARGA PACITAN SEBAGAI UPAYA PENCEGAHAN COVID 19
Authors: Indasari Rika Dwi , Susanto Haryanto , Monica Eva 
Published: March 2022

COVID-19 adalah penyakit infeksi saluran pernafasan yang disebabkan coronavirus (SARS CoV-2) dengan gejala umum berupa demam, sakit tenggorokan, sesak nafas, dan dapat menular melalui droplet dari pasien terinfeksi. Upaya pencegahan penyebaran COVID-19 dapat dilakukan dengan menerapkan Perilaku Hidup Bersih dan Sehat (PHBS) dan protokol kesehatan. Pemberian edukasi tentang PHBS dan protokol kesehatan diharapkan dapat meningkatkan pengetahuan masyarakat tentang PHBS dan protokol kesehatan sebagai upaya pencegahan COVID-19 sehingga dapat meningkatkan perilaku masyarakat dalam melakukan pencegahan penularan COVID-19.
Penelitian ini dilakukan dengan rancangan penelitian one-group pretest-posttest dengan memberikan kuesioner kertas sebelum dan setelah pemberian edukasi. Edukasi dilakukan dengan metode ceramah dengan menggunakan media slide dan flipchart. Pengolahan data menggunakan SPSS dengan uji non parametrik Wilxocon.
Pada uji statistik Wilcoxon diperoleh nilai signifikansi 0,000 yang berarti H0 ditolak, H1 diterima yang artinya terdapat perbedaan yang signifikan pada tingkat pengetahuan masyarakat tentang PHBS dan protokol kesehatan sebagai upaya pencegahan COVID-19 sebelum dan sesudah diberikan edukasi.
Computer-Based Test Application to Support E-Learning in Pandemic Situation
Authors: Marifati Imam Soleh , Mulyanto Joko Dwi , Kesuma Chandra , Ubaidillah Ubaidillah , Suripah Suripah 
Published: March 2022

The use of information technology in education is a new breakthrough. During the current COVID-19 pandemic, many teaching and learning activities are carried out online using the internet in the form of e-learning. one important part of e-learning is the test. Computer based test (CBT) can be implemented in schools that should be accessed by students from remote places. Computer-based test applications can be used as a complement to online learning by utilizing the web technology. Web-based applications allows access by students with an internet connection using PC/Laptop or other mobile devices. In addition, implementation costs can be saved because paperless. Computer-based test applications also make it easier for teachers to grade the answer where the application can automatically provide the score instantly when students finish the test. In this study, the application was built using the web technology that run from various devices and platforms. Access applications can be designed for local network use (intranet) or online by hosting the application on a webserver. The application development uses a system development life cycle approach using PHP-MySQL technology.

Keyword : CBT, computer base test, PHP-MySQL, webapps.
TO WHAT EXTENT DOES ORGANIZATIONAL CULTURE INFLUENCE ORGANIZATIONAL PERFORMANCE? EVIDENCE FROM THE DEPARTMENT OF POPULATION AND CIVIL REGISTRATION, TRENGGALEK REGENCY, EAST JAVA PROVINCE
Authors: Baidhowah Adfin Rochmad 
Published: March 2022

Cultural aspects within an organization will determine the direction of the performance of an organization whether leading to a better pendulum or toward a stagnant pendulum. The issue of the performance of e-ID card service in the Department of Population and Civil Registry of Trenggalek Regency shows the absence of aspect in organizational culture which has an impact on the organization's performance whether it is evaluated objectively internal government and objectively from the viewpoint of the service recipient community. Organizational culture is a system of shared meanings embraced by members who distinguish an organization from other organizations. This shared system of meanings, when examined more thoroughly, is a set of key characteristics valued by an organization. Research on the influence of organizational culture on organizational performance in the Department of Population and Civil Registry of Trenggalek Regency using quantitative method with survey research approach conducted on the object of research. The influence of organizational culture variable (X) toward organizational performance (Y) shows the total influence of p = 0,584 or 58,4% and t value equal to 2,099 and t value table equal to 1,985, giving meaning that there is significant influence of organizational culture variable as Independent variable toward performance variable. And the value of the effect of epsilon variables ie other variables not studied in this study, that is equal to 0.416 or 41.6%.
Key Words: Organizational Culture, Organizational Performance and eKTP Service.
INOVASI QR CODE PADA PENCETAKAN DOKUMEN DATA PENDUDUK SEBAGAI WUJUD PENERAPAN ASAS PENYELENGGARAAN PEMERINTAHAN
Authors: Mubaroq Husni , Fitria Nurul Jannah Lailatul 
Published: March 2022

The Indonesian government has made reforms to the system of governance. Included in the system of administration of government administration. This form of renewal is by optimizing the use of information and communication technology which is increasingly sophisticated and coupled with an internet base. This renewal is called innovation with elements of technological sophistication, bringing the Indonesian government as a form of bureaucratic digitization or E-government. One of these reforms or innovations is in the Population Administration sector. The Directorate General of Dukcapil has the innovation of implementing document printing by adding a QR Code. The goal is to make public services in the population administration sector easier, better, and consistent with the principle of protecting population data. This study will describe the QR Code innovation on population documents in accordance with the principles of governance in Probolinggo City. This research method applies descriptive-oriented qualitative. The data input method is by observing phenomena related to the object of research and obtaining data from literature studies. So that it can be seen that the QR Code is a form of innovation by the Probolinggo City government in public services in the population administration sector in accordance with the legislation containing the principles of governance.
Key Words: Population Administration, Barcodes, Public service.
Bio-Inspired Hierarchical Micro/Nanostructured Surfaces for Superhydrophobic and Anti-Ice Applications
Authors: Zhang Lansheng , Uzoma Paul C. , Xiaoyang Chu , Penkov Oleksiy V. , Hu Huan 
Published: March 2022

We report a scalable and cost-effective fabrication approach for constructing bio-inspired micro/nanostructured surfaces. It involves silicon microstructure etching using a deep reactive ion etch (DRIE) method, nanowires deposition via glancing angle deposition (GLAD) process, and fluorocarbon thin film deposition. Compared with the smooth, microstructured, and nanostructured surfaces, the hierarchical micro/nanostructured surfaces obtained via this method showed the highest water contact angle of ∼161° and a low sliding angle of &lt;10°. It also offered long ice delay times of 2313 s and 1658 s at −5°C and −10°C respectively, more than 10 times longer than smooth surfaces indicating excellent anti-icing properties and offering promising applications in low-temperature environments. These analyses further proved that the surface structures have a significant influence on surface wettability and anti-icing behavior. Hence, the GLAD process which is versatile and cost-effective offers the freedom of constructing nanostructures on top of microstructures to achieve the required objective in the fabrication of micro/nanostructured surfaces when compared to other fabrication techniques.
Usefulness of Platelet Distribution Width and Fibrinogen in Predicting In-stent Restenosis With Stable Angina and Type 2 Patients With Diabetes Mellitus
Authors: Chai Dayang , Yang Xi , Wang Aichao , Lu Shu , Dai Yuxiang , Zhou Jing 
Published: March 2022

AimThe purpose of this study was to investigate the predicting value of platelet distribution width (PDW) and fibrinogen for in-stent restenosis (ISR) in patients with stable angina pectoris and type 2 diabetes mellitus (T2DM) after drug-eluting stent (DES) implantation.MethodsWe enrolled 161 patients who were readmitted with recurrent chest pain and successfully reviewed for coronary angiography and were divided into the ISR and non-ISR groups. We compared the levels of PDW and fibrinogen between the two groups. Logistic regression was used for analyzing independent predictors of ISR. The receiver operating characteristic (ROC) curve analysis was used to determine the optimum cutoff points of PDW and fibrinogen to predict ISR. The Kaplan–Meier survival curves for target lesion failure (TLF) by levels of PDW and fibrinogen.ResultsThe multivariate logistic regression analysis showed that PDW and fibrinogen were independent predictors of ISR [odds ratio (OR) = 1.209, 95% CI: 1.024–1.427, p = 0.025; OR = 1.006, 95% CI: 1.002–1.011, p = 0.010, respectively]. The ROC analyses showed that PDW ≥ 13.15% and fibrinogen ≥ 333.5 mg/dl were predictive of ISR in patients with stable angina pectoris and T2DM after DES implantation. However, the Kaplan–Meier estimate for TLF showed no statistical significance.ConclusionHigher levels of PDW and fibrinogen were associated with the incidence of ISR in patients with stable angina with T2DM after DES implantation, but were not independent predictors of TLF.
A Novel Idiopathic Atrial Calcification: Pathologic Manifestations and Potential Mechanism
Authors: Li Bowen , Liu Qingbo , Chen Xihui , Chen Tangdong , Dang Wenhui , Zhao Jing , Cui Guangbin , Chen Kun , Wu Yuanming 
Published: March 2022

BackgroundCardiac calcification is a type of ectopic pathologic calcification of unknown etiology and mechanisms. Once diagnosed, the location, extent and morphology of the calcified lesions, as well as their functional significance in the heart, are usually the focus of case reports. Calcification is mostly distributed in myocardium, but rarely reported in atrium. In addition, because of limited sampling and complex pathological mechanisms, the etiology underlying the formation of these calcified lesions also remains unclear.MethodsTwo cardiac calcifications were found in a patient, died of trauma-induced subarachnoid hemorrhage after slightly drinking, during a standard autopsy. The location and morphological characteristics of the calcified lesions were determined by computed tomography (CT) and CT-based 3D reconstruction. The specific histopathological characteristics of the lesions were determined by multi-staining. The concentration of free calcium and inorganic pyrophosphate (PPi) in plasma reflected the change of calcium metabolism. The expression and membranal localization of the ATP Binding Cassette Subfamily C Member 6 (ABCC6) in hepatocytes were detected by immunofluorescence. The variants of the ABCC6 were detected by Sanger sequencing and potential pathogenic variants were further identified by in silico analysis.ResultsThe present study describes a patient with idiopathic calcification with two pear-shaped and irregularly hollow lesions symmetrically distributed in the patient's atrium. Massive accumulation of calcium salts was identified by multi-staining. For this patient, the plasma concentration of free calcium was higher than the control, indicating that calcium metabolism was disturbed. Furthermore, the plasma PPi of the patient was lower than the normal. By using immunofluorescence, the expression and membranal localization of ABCC6 was decreased and impaired in hepatocytes, respectively. Combined with Sanger sequencing and in silico analysis, 7 variants were identified.ConclusionsThis study described a novel patient with symmetrically distributed idiopathic atrial calcifications. Furthermore, all the results indicated that these pathologic calcifications may be secondary to reduced plasma PPi content due to ABCC6 dysfunction in hepatocytes. Moreover, these findings provided novel clues to the pathogenesis, clinical diagnosis and treatment of idiopathic atrial calcification in future.
Co-Expression Network Modeling Identifies Specific Inflammation and Neurological Disease-Related Genes mRNA Modules in Mood Disorder
Authors: Yang Chunxia , Zhang Kun , Zhang Aixia , Sun Ning , Liu Zhifen , Zhang Kerang 
Published: March 2022

Objectives: Mood disorders are a kind of serious mental illness, although their molecular factors involved in the pathophysiology remain unknown. One approach to examine the molecular basis of mood disorders is co-expression network analysis (WGCNA), which is expected to further divide the set of differentially expressed genes into subgroups (i.e., modules) in a more (biologically) meaningful way, fascinating the downstream enrichment analysis. The aim of our study was to identify hub genes in modules in mood disorders by using WGCNA.Methods: Microarray data for expression values of 4,311,721 mRNA in peripheral blood mononuclear cells drawn from 21 MDD, 8 BD, and 24 HC individuals were obtained from GEO (GSE39653); data for genes with expression in the bottom third for 80% or more of the samples were removed. Then, the top 70% most variable genes/probs were selected for WGCNA: 27,884 probes representing 21,840 genes; correlation between module genes and mood disorder (MDD+BD vs. HC) was evaluated.Results: About 52% of 27,765 genes were found to form 50 co-expression modules with sizes 42–3070. Among the 50 modules, the eigengenes of two modules were significantly correlated with mood disorder (p &lt; 0.05). The saddlebrown module was found in one of the meta-modules in the network of the 50 eigengenes along with mood disorder, 6 (IER5, NFKBIZ, CITED2, TNF, SERTAD1, ADM) out of 12 differentially expressed genes identified in Savitz et al. were found in the saddlebrown module.Conclusions: We found a significant overlap for 6 hub genes (ADM, CITED2, IER5, NFKBIZ, SERTAD1, TNF) with similar co-expression and dysregulation patterns associated with mood disorder. Overall, our findings support other reports on molecular-level immune dysfunction in mood disorder and provide novel insights into the pathophysiology of mood disorder.
The Distributional Characteristics of M2 Macrophages in the Placental Chorionic Villi are Altered Among the Term Pregnant Women With Uncontrolled Type 2 Diabetes Mellitus
Authors: Zhang Muqiu , Cui Dong , Yang Huixia 
Published: March 2022

AimNo definite conclusions have been drawn regarding how prolonged exposure to hyperglycemia affects the distribution of macrophages in the placenta, especially in pregnant women with uncontrolled type 2 diabetes mellitus (T2DM). Herein, we explored the distributional characteristics of placental M2 macrophages, including hofbauer cells (HBCs) in the chorionic villi and decidual macrophages, in pregnant women with uncontrolled T2DM.MethodsSix healthy singleton pregnancies and five uncontrolled T2DM singleton pregnancies were collected. Multicolor immunofluorescence and immunohistochemistry were performed to record M1 macrophages by CD80 and CD86, the general M2 macrophages by CD163, M2a macrophages by CD163 and DG-SIGN, M2b macrophages by CD163 and CD86, and M2c macrophages by CD163 and CD206. Meanwhile, the monocyte marker of CD14 and the general macrophage marker of CD68 were also documented on placenta.ResultsIn the chorionic villi and decidua, the most common infiltrated macrophages was the general M2. There were only few M1 and M2b macrophages distributed in the placenta of both the healthy and uncontrolled T2DM groups. The infiltrated degree of M2c macrophages was moderate in chorionic villi and decidua. The uncontrolled T2DM and healthy pregnant women had a comparable amount of M2c macrophages infiltration in the chorionic villi (p = 0.158). Notedly, in both of the healthy and uncontrolled T2DM pregnant women, the predominant subtype of M2 macrophages in the chorionic villi was M2a, where it mainly infiltrated around vessels and syncytiotrophoblasts. The uncontrolled T2DM pregnant women had more M2a macrophage infiltration than the healthy pregnant women (p = 0.016). The M2a macrophages in the decidua of the uncontrolled T2DM group were similar to those of the normal group (p = 0.800). Meanwhile, it was in the chorionic villi but not the decidua, that the CD68+ macrophages and CD14+ M2a macrophages were also elevated in the uncontrolled T2DM group (p = 0.035 and 0.044, respectively).ConclusionThese results confirmed that the M2 macrophages exhibited increased in the chorionic villi of pregnant women with uncontrolled T2DM. The subsets of M2 macrophages in the placental decidua were similar between uncontrolled T2DM pregnant women and normal groups. It may provide a basis for exploring the functions of different subsets of macrophages in the placental chorionic villi.
Development and Validation of a Novel Tool for the Prediction of Clopidogrel Response in Chinese Acute Coronary Syndrome Patients: The GeneFA Score
Authors: Wu Hongyi , Li Xiaoye , Qian Juying , Zhao Xin , Yao Yao , Lv Qianzhou , Ge Junbo 
Published: March 2022

Aim: Growing evidence indicated that CYP2C19 genotypes could only explain a fraction of the pharmacodynamic response to clopidogrel, while a number of clinical factors also have contributing roles. Our objective was to develop a new risk score to improve prognostication of ischemic events in Chinese patients treated with clopidogrel.Methods: A new risk score was developed and internally validated in 445 patients with acute coronary syndrome (ACS) undergoing coronary stenting. The final score was named the GeneFA score based on the inclusion of CYP2C19 genotype, fibrinogen, and age. External validation of the GeneFA score and comparison with the ABCD-GENE score were performed in an independent ACS cohort.Results: Based on the observed frequencies of high platelet reactivity (HRPR) in relation to the GeneFA risk score, a relatively higher clinical HRPR was observed in the upper quintile with a representative score of 3 (52.90%) and 4 (59.10%), whereas it was found less frequently in groups with scores 0 (6.70%), 1 (15.10%), and 2 (16.70%). Participants with a GeneFA score &gt;2 had an increased risk of HRPR (54.3 vs. 14.7%, p &lt; 0.001) and ischemic recurrence (20.7 vs. 5.4%, p &lt; 0.001). The GeneFA score exhibited a better prediction for high HRPR patients as compared to the ABCD-GENE score (p &lt; 0.001). In the validation population, GeneFA illustrated a similarly high prognostic value for HRPR incidence (C-statistic: 0.855 for GeneFA and 0.843 for ABCD-GENE) and ischemic recurrence (C-statistic: 0.726 for GeneFA and 0.724 for ABCD-GENE) on clopidogrel as compared to ABCD-GENE.Conclusion: The GeneFA risk score had a moderate predictive ability for HRPR on clopidogrel for CAD patients in Chinese populations. The predictive value of the GeneFA score was consistent with the ABCD-GENE score for HRPR identification.
Flavanone Glycosides, Triterpenes, Volatile Compounds and Antimicrobial Activity of Miconia minutiflora (Bonpl.) DC. (Melastomataceae)
Authors: Ferreira Nathália Siso , Cascaes Márcia Moraes , da Silva Santos Lourivaldo , de Oliveira Mozaniel Santana , das Graças Bichara Zoghbi Maria , Araújo Isabella Santos , Uetanabaro Ana Paula Trovatti , de Aguiar Andrade Eloisa Helena , Guilhon Giselle Maria Skelding Pinheiro 
Published: March 2022

Chemical composition of the essential oils and extracts and the antimicrobial activity of Miconia minutiflora were investigated. The flavanone glycosides, pinocembroside and pinocembrin-7-O-[4″,6″-HHDP]-β-D-glucose, were identified, along with other compounds that belong mainly to the triterpene class, besides the phenolics, gallic acid and methyl gallate. Sesquiterpenes and monoterpenes were the major compounds identified from the essential oils. Screening for antimicrobial activity from the methanolic extract of the leaves showed that the MIC and MMC values against the tested microorganisms ranged from 0.625 to 5 mg·mL−1 and that the extract was active against microorganisms, Staphyloccocus aureus, Escherichia coli, and Bacillus cereus.