bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of pulmonary air leak after lobectomies
Authors: Akopov A. L. , Agishev A. S. , Mishra R. P. , Kovalev M. G. , Parshin E. V. , Dvoreckiy S. Yu. , Zaripova Z. A. , Rabik Yu. D. , Skvortsova R. D. , Obukhova A. A. 
Published: September 2022

The OBJECTIVE was to identify prognostic factors of long-term air leak after lobectomies based on the analysis of the main preoperative and surgical clinical and functional indicators.METHODS AND MATERIALS. A retrospective study included 71 patients who underwent lung resection in the volume of lobectomy for lung cancer. The patients were divided into three groups - group 1 (n=42, 59 %) - air leak through the drains stopped within a day after surgery; group 2 (n=10, 14 %) - the duration of air leak from the pleural cavity from 1 to 5 days; group 3 (n=19, 27 %) the duration of air leak more than 5 days after surgery.RESULTS. The average values of the main clinical, surgical and functional indicators, such as the frequency of concomitant COPD, the severity of its course, smoking status, access (thoracotomy / thoracoscopy) in the three groups were almost the same. The difference in the average value of DLCO was characterized by the greatest tendency to reliability: the longer the pulmonary air leak was, the lower the values of this indicator turned out to be. Correlation analysis revealed a noticeable feedback between the long-term pulmonary air leak and the preoperative level of FEV1 (r=-0.59), a direct relationship between the level of FEV1 and DLCO (r=0.51), as well as a noticeable feedback between the long-term pulmonary air leak and the level of DLCO (r=-0.61) and a direct moderate relationship between the pulmonary air leak and the time spent on the stair climbing test (r=0.38).CONCLUSIONS. The combination of a low level of FEV1, a low level of DLCO and a long duration of the stair climbing test makes it possible to assess the risk of prolonged pulmonary air leak as significant and take this into account during the surgical intervention.
The cluster analysis of patients with morbid obesity in bariatric and metabolic surgery
Authors: Voskanyan S. E. , Samoylov V. S. , Redkin A. N. 
Published: September 2022

INTRODUCTION. Existing classifications of various forms of obesity are poorly adapted to the practical goals of bariatric surgery from the standpoint of personalizing the choice of method and volume of intervention.The OBJECTIVE was develop new approaches to stratification of patients with morbid obesity based on cluster analysis; to evaluate of the effectiveness and safety of metabolic surgical interventions, depending on the belonging of patients to a particular bariatric cluster.METHODS AND MATERIALS. The study included 745 bariatric patients. To form clinical and demographic groups, a two-stage cluster analysis procedure was used using the SPSS 16.0 package with 11 categorical and 2 quantitative variables. The efficacy and safety of metabolic surgical interventions depending on the patients' belonging to a particular bariatric cluster was evaluated.RESULTS. As a result of cluster analysis in the general population of patients with morbid obesity, 3 unique clinical and demographic groups (clusters) of patients were identified, characterized by an initial set of similar indicators that differed from that in patients of other groups (clusters): the1st cluster: «premorbid obesity»; the 2nd cluster: «morbid obesity without metabolic syndrome and complications»; the 3rd cluster: «morbid obesity with metabolic syndrome and/ or complications». The best long-term results on the BAROS scale were generally observed in patients of the 1st cluster (87.8 % of excellent and good results compared to 66.7 % in patients of the 2nd clusters and 65.5 % in patients of the 3rd cluster, p<0.001). The total risk of serious complications in patients of the 3rd cluster was 2.4 times higher than in patients of the 1st cluster (P<0.05) and 1.9 times higher than in patients of the 2nd cluster (P>0.05).CONCLUSION. The procedure of clustering patients with obesity allows individualizing the indications for conducting and choosing bariatric interventions.
Adaptation and validation of the Bengali version of the Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL)
Authors: Dhabal Arunima , Mondal Himel , Mondal Shaikat , Baiardini Ilaria , Chakraborty Sankha Subhra , Chakraborty Tamali , Podder Indrashis 
Published: September 2022

Background
Chronic urticaria exerts a profound impact on quality of life. Recent guidelines recommend its evaluation in all chronic urticaria patients. Currently, the Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL) is the only validated tool to assess chronic urticaria-specific quality of life.

Objective
To validate and adapt the CU-Q2oL to the Bengali language for its widespread use.

Methods
The CU-Q2oL questionnaire was translated into Bengali. Its internal consistency and reliability were tested by asking 42 chronic urticaria patients to complete this version. They completed the validated Bengali Dermatology Life Quality Index and Urticaria Control test questionnaires, and their scores were correlated with CU-Q2oL score to assess the validity of our Bengali version.

Results
The mean CU-Q2oL score of our patients (mean age 38.41 ± 13.4 years, male: female 29:13) was 48.8 ± 16.5. Domain 4 (sleep problems) was worst affected, followed by domain 1 (pruritus), while domain 2 (swelling) was least affected. We detected an excellent overall internal consistency (Cronbach’s alpha = 0.93) of our version and nearly complete agreement (intra-class correlation coefficient = 0.91) between the test-retest scores. We found a significant positive correlation between the overall CU-Q2oL and Dermatology Life Quality Index scores (rs = 0.53, P = 0.0002), thus implying the validity of our version. Additionally, we noted a significant negative correlation between the overall CU-Q2oL and Urticaria Control test scores (rs = -0.48, P = 0.0007), suggestive of a more severe impairment of quality of life with poorer disease control.

Limitations
Small sample size, observational design and bias in test-retest reliability analysis due to the use of rescue therapy in-between assessment sessions were important limitations of our study.

Conclusion
The Bengali version of CU-Q2oL questionnaire is a valid and reliable tool suitable for both clinical and research use in Bengali speaking chronic urticaria patients.
Ectopic schwannoma of the sellar region in a 1-year-old child: A case report and review of literature
Authors: Sadiqo Rauf , Abdulsada Alkawthar M. , Ismail Mustafa , Hoz Samer S. 
Published: September 2022

Background:
Schwannomas are cranial and spinal nerves’ sheath tumors accounting for up to 8% of all intracranial neoplasms. Although typical intracranial schwannomas originate from Schwann cells surrounding cranial nerves, ectopic schwannomas are not associated with a known cranial nerve or have an unknown origin. The location of schwannomas may impose clinical challenges. Sellar region schwannomas are rare whether it is ectopic or not. Herein, we report a pediatric case of a 1-year-old female with ectopic, intra-supra sellar with a literature review. We report the first case of juvenile ectopic schwannoma in the sellar region.

Methods:
A PubMed Medline database search was performed by the following combined formula of medical subject headings (MESH) terms and keywords: ((sella turcica [MeSH Terms]) OR (sella*[Title/Abstract]) OR (ectopic [Title/Abstract]) AND ((neurilemmoma [MeSH Terms]) OR (schwannoma [Title/Abstract]) OR (neuroma [Title/Abstract]) OR (neurinoma [Title/Abstract])).

Results:
Total results of 206 articles were obtained. In exclusion of intraparenchymal and intraventricular schwannomas, only 34 articles remained. Thirty-nine cases were included in 34 articles. According to the reported cases, intrasellar schwannomas are more common in elderly individuals in an average of 49.5 years (range: 19– 79 years). They have a good prognosis and affect males to females equally (20:19).

Conclusion:
Ectopic schwannoma sited in the sellar region is rare. It is the first case to be reported in the pediatric age group with a literature review. This lesion should be highlighted and included in the differential diagnosis of sellar mass.
KARAKTERISASI PREPARAT NANOPARTIKEL KAFEIN DARI EKSTRAK KOPI ROBUSTA MENGGUNAKAN PLGA DAN PVA
Authors: Saputri Rika , Kamaluddin Muhammad Totong , Theodorus Theodorus , Mangunsong Sonlimar 
Published: September 2022

Kopi merupakan salah satu minuman yang digemari oleh masyarakat luas.Kopi mengandung kafein yang mampu meningkatkan konsentrasi dan kemampuan ini berlangsung tergantung dari dosis yang diterima oleh tubuh.Tujuan Penelitian ini untuk mengkarakterisasi nanopartikel kafein berpolimer PLGA dan Pva.Dalam pembuatan nanopartikel kafein ini menggunakan bahan berupa biji kopi robusta yang telah dijemur dan disangrai yang selanjutnya dilakukan proses ekstraksi dengan metode digesti, sehingga didapatkan kafeinnnya. Kemudian kafein yang telah didapat di buat menjadi formulasi nanopartikel berpolimer PLGA dan PVA. Dalam proses pembuatan formulasi nanopartikel ini digunakan metode emulsion solvent evaporation.Formulasi nanopartikel kafein ini dilakukan karakterisasi menggunakan PSA dan dilakukan pengmatan morfologi partikelnya menggunakan TEM. Hasil karakterisasi menggunakan PSA didapatkan diameter rata rata sebesar 173,8 nm,zeta potensialnya -16,2 mV dan PDI sebesar 0,148.Untuk morfologinya telihat bentuk permukaannya spheric. Sehingga kafein dari biji kopi orbusta dapat dipreparasi menggunakan polimer PLGA dan PVA dengan menggunakan metode emulsion solvent evaporation.
Poly Acrylamide Gel Electrophoresis of Serum Protein, Application to Kala-azar Patients
Authors: M.T. Al-Bashir Nada 
Published: September 2022

Sera samples were collected from 60 children aged 4-60 months, all were clinically and serologically proven cases of visceral leishmaniasis, as well as from 10 healthy children, all were seronegative with no history of parasitic infection who serve as a control during the study. Serum total protein and albumin were measured and compared between the control and visceral leishmaniasis patients. Serum protein profiles have been investigated using the conventional sodium dodecyl sulphate â€“ polyacrylamide gel electrophoresis (SDS-PAGE). Serum of control group showed the specific protein pattern with five protein bands, while serum protein profile in visceral leishmaniasis patients revealed three groups of electrophoretic banding patterns. , 50% showed twelve bands, 36.66% of the patients showed nine bands and 13.33% showed ten bands. At least four of these bands were found to be common among the infected groups which may be of diagnostic value and required further investigations. The three different electrophoretic patterns groups may be correlated with the previous epidemiological observations in respect of different clinical presentation of the disease and different response the chemotherapeutic agents at many endemic areas around the world.
Key words: Protein band, protein patterns, serum protein, sodium dodecyl sulphate-poly acrylamide gel electrophoresis (SDS-PAGE), visceral leishmaniasis.
Synthesis of 5-Fluorouracil Derivatives as Possible Mutual Prodrugs with Meloxicam and Ibuprofen for Targeting Cancer Tissues
Authors: A.H. Dakhel Zainab 
Published: September 2022

In the present study, five derivatives have been designed to be synthesized as possible mutual prodrugs for 5-Fluorouracil (5-FU) and non steroidal anti-inflammatory drugs (NSAIDs) to selectively deliver the drugs into the cancer cells. The synthesis of the target compounds were accomplished following multistep reaction procedures, the chemical reaction followed up and the purity of the products were checked by TLC. The structure of the final compounds and their intermediates were confirmed by their melting points, infrared spectroscopy and elemental microanalysis, the hydrolysis of compound III was studied using HPLC technique. According to the results mentioned above, compounds (Iâˆ’V) can be good candidates as possible mutual prodrugs of 5-FU and NSAIDs that can selectively deliver the parent drugs into the cancer cells by the effect of enzymes that elevated in tumor tissues compared with normal tissues.
Key wards: Anticancer, 5-Fluorouracil, NSAIDs, prodrug.
Study the Effect of Arabidopsis thaliana Extract on Reducing Blood Glucose Level in Diabetic White Albino Mice
Authors: I. Rashid Khaleel , M. Aljibouri Abedaljasim , J. Zayer AbdulAmeer , B. Khalid Luma , Abdul-Munaem Ahmed 
Published: September 2022

This study was designed to evaluate the effect of aqueous extract of Arabidopsis thaliana seeds on reducing glucose level for white albino mice. Twenty adults mice were used, divided randomly into four groups (five mice per each group). The first group (normal mice) was administrated with 0.1 ml of distilled water as a control, the second group (normal mice) was administrated with 0.1 ml of the plant extract, whereas the third and fourth groups (diabetic mice) were administrated with single dose of alloxan (150 mg/kg of the body weight) to induce diabetes, and the fourth group was administrated with 0.1 ml of the plant extract for 10 days, then blood glucose level was measured for all of the experimental animals (diabetic and non diabetic). Results showed clear increasing in glucose levels in the diabetic mice, while significant reduction was recorded in glucose levels of the normal mice that was treated with the plant extract as compared with the control group. These results indicate that Arabidopsis thaliana seeds aqueous extract possesses a hypoglycemic effect.
Key words: Arabidopsis thaliana, glucose level, albino mice
Formulation and Evaluation of Bilayer Tablets Containing Immediate Release Aspirin Layer and Floating Clopidogrel Layer
Authors: M.Toma Nawar , I.Khalil Yehia 
Published: September 2022

Aspirin and clopidogrel are considered the most important oral platelets aggregation inhibitors. So it is widely used for treatment and prophylaxis of cardiovascular and peripheral vascular diseases related to platelets aggregation .In this study aspirin and clopidogrel were formulated together as floating bilayer tablet system. Three different formulas of 75 mg aspirin were prepared by wet granulation method as immediate release layer; different disintegrants used to achieve rapid disintegration. Formula with crosscarmellose as disintegrant achieve rapid disintegration was selected for preparation of bilayer tablet.
Different formulas of 75 mg clopidogrel were prepared as sustained release floating layer by wet granulation (effervescent ) method ;the physical and floating properties for compressed clopidogrel matrix were studied in addition to study the effect of polymer concentration(HPMC) ,and its combination with ethyl cellulose and carbapol ,effect of different diluents and effect of increasing sodium bicarbonate amount on the release from compressed matrix .
Formula prepared with HPMC and EC in a ratio of 1:1 was capable to retard the release of clopidogrel for 6 hours in addition to its good floating behavior and therefore selected to prepare bilayer tablets in combination with selected aspirin layer.
The prepared bilayer tablets were further subjected to evaluation of their physical, floating properties and release behavior. Finally the kinetic study reflects acceptable shelf life for aspirin and clopidogrel.
Key words: Aspirin, Clopidogrel, Bilayer tablet, Floating tablet.
Phytochemical Investigation of Alkaloids in the Iraqi Echinops heterophyllus (Compositae)
Authors: J. Khadim Enas , A. Abdulrasool Alaa , J. Awad Zainab 
Published: September 2022

Alkaloids are a group of naturally occurring chemical compounds that contain mostly basic nitrogen atoms . They are a large family of compounds synthesized by plants in addition to the bacteria, fungi, and animals, they often have pharmacological effects. The aim of this study is to isolate and identified alkaloids in a newly studied, wild Iraqi plant named Echinops heterophyllus. The medicinal importance of alkaloids, on one hand and the absence of any phytochemical investigation on heterophyllus species of echinops genus on the other hand , acquired this study its importance. Three alkaloids (named E1, E2 and E3) were isolated from seed plant part by two chromatographic methods: Preparative high Performance Liquid Chromatography (PHPLC) and preparative thin layer chromatography (PTLC), one of them identified as(1-Methyl-2,3-dihydro-4(1H)-quinolinone by different chemical analysis like: ultra violet spectrum analysis (UV spectrum), Fourier transforms infrared spectra (FT-IR) , elemental microanalysis (CHN) and Proton1H-NMR and carbon 13C-NMR analysis.
Key words: Echinops, heterophyllus, quinoline alkaloids.
Quality of Life of Patients with Type II Diabetes Mellitus in Al- Hilla City-Iraq
Authors: F. Al - Tukmagi Haydar , A. Moussa Miamin 
Published: September 2022

Diabetes mellitus is a global problem nowadays due to increase the disease cases all over the world, in both the developed and developing countries which may affect the quality of life (QOL ) of diabetic patients. This study was conducted to assess the quality of life of patients with type 2 diabetes mellitus (DM) and to determine some selected clinical and sociodemographic factors that affect the quality of life of these patients in Al Hila city-Iraq. This was a cross sectional study in which 100 patients with type 2 diabetes mellitus attending diabetic outpatient clinics of Merjan Teaching Hospital-Al Hila. To assess the quality of life of those diabetic patients, the World Health Organizations Quality of Life Assessment (WHOQOL) was applied, but in a short version questionnaire and abbreviated form called (WHOQOL-BREF).
Concerning the results of this study, it was found that the patients responded fairly well on the questionnaire used, 39% had good score, 47% had fair score and 14% had poor score. For physical health domain 17% had poor score, for social domain 22% had poor score, for psychological domain 19% and environmental domain 18% had poor score.
It was concluded from the results that although it supports previous reports in which QOL of patients with DM were fairly good but this disease is significantly affects physical health, social relations and environment. Furthermore, there is association with marked impairment in aspects of quality of life relating to mental health and psycho-social functioning and at least some aspects of physical health. Given this, and given its high prevalence, greater attention is needed to watch DM as a public health problem. The fact that DM is â€œnormativeâ€ should not be taken to infer that it is benign.
Keywords: Diabetes mellitus, Quality of life.
Monitoreo continuo de glucosa durante la gestación en pacientes con diabetes mellitus tipo 2 pregestacional
Authors: Del Mar Morales María , Acho Edwin , Castrillón Carolina , Marcelo Humberto , Vera Edy , Lopez Eddy , Zhang Cristian , Leey Julio 
Published: September 2022

La diabetes pregestacional requiere un control glicémico estricto durante el embarazo. Los dispositivos de monitoreo continuo de glucosa (MCG) miden niveles de glucosa intersticial sin necesidad de punción capilar. Se estudió 4 gestantes con diabetes mellitus tipo 2 pregestacional con la ayuda del MCG durante 2 semanas de su gestación. Ellas tuvieron sesiones nutricionales semanales y controles médicos con un endocrinólogo. El promedio de nivel de glucosa osciló entre 82 y 171 mg/dL. El MCG permitió cambios tempranos en el tratamiento de una paciente con hipoglicemia. Todas las pacientes manifestaron que el MCG les ayudó en la selección de sus alimentos. En conclusión, el MCG ayudó en el reconocimiento de carbohidratos y en el reajuste del tratamiento. El MCG tuvo buena aceptación de su uso.
Genetic Screening in Korean Patients with Frontotemporal Dementia Syndrome
Authors: Kim Eun-Joo , Na Duk L. , Kim Hee-Jin , Park Kyung Won , Lee Jae-Hong , Roh Jee Hoon , Kwon Jay C. , Yoon Soo Jin , Jung Na-Yeon , Jeong Jee Hyang , Jang Jae-Won , Kim Hee-Jin , Park Kee Hyung , Choi Seong Hye , Kim SangYun , Park Young Ho , Kim Byeong C. , Youn Young Chul , Ki Chang-Seok , Kim Seung Hyun , Seo Sang Won , Kim Young-Eun 
Published: September 2022

Background: Frontotemporal dementia (FTD) syndrome is a genetically heterogeneous group of diseases. Pathogenic variants in the chromosome 9 open reading frame 72 ( C9orf72), microtubule-associated protein tau ( MAPT), and progranulin ( GRN) genes are mainly associated with genetic FTD in Caucasian populations. Objective: To understand the genetic background of Korean patients with FTD syndrome. Methods: We searched for pathogenic variants of 52 genes related to FTD, amyotrophic lateral sclerosis, familial Alzheimer’s disease, and other dementias, and hexanucleotide repeats of the C9orf72 gene in 72 Korean patients with FTD using whole exome sequencing and the repeat-primed polymerase chain reaction, respectively. Results: One likely pathogenic variant, p.G706R of MAPT, in a patient with behavioral variant FTD (bvFTD) and 13 variants of uncertain significance (VUSs) in nine patients with FTD were identified. Of these VUSs, M232R of the PRNP gene, whose role in pathogenicity is controversial, was also found in two patients with bvFTD. Conclusions: These results indicate that known pathogenic variants of the three main FTD genes ( MAPT, GRN, and C9orf72) in Western countries are rare in Korean FTD patients.
ДЕРЖАВНА ПОЛІТИКА ІННОВАЦІЙНОГО РОЗВИТКУ АГРАРНОГО СЕКТОРУ В УКРАЇНІ: ОРГАНІЗАЦІЙНО-ПРАВОВІ ЗАСАДИ
Authors: ШЕСТАКОВСЬКА Тетяна 
Published: September 2022

В статті автором розкрито проблему організаційно-правових засад формування та реалізації державної політики інноваційного розвитку аграрного сектору в Україні. Проаналізовано еволюцію функціонування нормативно-правового забезпечення державного регулювання інноваційного розвитку аграрного сектору в Україні. Законодавчими актами, які є складовою механізму правового забезпечення державної політики інноваційного розвитку агарного сектору, визначені та конкретизовані напрями інноваційно-інвестиційних процесів щодо активності та результативності інноваційної діяльності суб’єктів господарювання, пріоритети наукового та агропромислового потенціалу в середині країни з урахуванням її місця у геополітичній світовій системі. Оптимальним варіантом проведення активної державної політики із стимулювання розвитку інноваційних процесів в Україні є їх реалізація на принципах розвитку інвестиційної діяльності, підвищення результативності та прозорості механізмів державно-приватного партнерства у аграрному секторі в контексті реалізації інноваційно-інвестиційних проектів. Запропоновано розробити законопроект щодо інноваційного розвитку аграрного сектору, який повинен бути орієнтований на системність й узгодженість впровадження заходів із реалізації державної політики та забезпечення стабільного розвитку аграрного сектору, у тому числі, сталого розвитку сільських територій, доступу суб'єктів господарювання до ринків агропромислової продукції. Основною метою такого законопроекту має бути створення законодавчої основи для закріплення основних засад реалізації ефективної державної аграрної політики та державної політики сільського розвитку в умовах децентралізації.