bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling Preclinical Cancer Studies under Physioxia to Enhance Clinical Translation
Authors: Adebayo Adedeji K. , Nakshatri Harikrishna 
Published: September 2022

Abstract
Oxygen (O2) plays a key role in cellular homeostasis. O2 levels are tightly regulated in vivo such that each tissue receives an optimal amount to maintain physiologic status. Physiologic O2 levels in various organs range between 2% and 9% in vivo, with the highest levels of 9% in the kidneys and the lowest of 0.5% in parts of the brain. This physiologic range of O2 tensions is disrupted in pathologic conditions such as cancer, where it can reach as low as 0.5%. Regardless of the state, O2 tension in vivo is maintained at significantly lower levels than ambient O2, which is approximately 21%. Yet, routine in vitro cellular manipulations are carried out in ambient air, regardless of whether or not they are eventually transferred to hypoxic conditions for subsequent studies. Even brief exposure of hematopoietic stem cells to ambient air can cause detrimental effects through a mechanism termed extraphysiologic oxygen shock/stress (EPHOSS), leading to reduced engraftment capabilities. Here, we provide an overview of the effects of ambient air exposure on stem and non-stem cell subtypes, with a focus on recent findings that reveal the impact of EPHOSS on cancer cells.
Protein Kinase C Alpha is a Central Node for Tumorigenic Transcriptional Networks in Human Prostate Cancer
Authors: Cooke Mariana , Zhang Xuyao , Zhang Suli , Eruslanov Evgeniy , Lal Priti , Daniel Reba E. , Feldman Michael D. , Abba Martin C. , Kazanietz Marcelo G. 
Published: September 2022

Aberrant expression of protein kinase C (PKC) isozymes is a hallmark of cancer. The different members of the PKC family control cellular events associated with cancer development and progression. Whereas the classical/conventional PKCα isozyme has been linked to tumor suppression in most cancer types, here we demonstrate that this kinase is required for the mitogenic activity of aggressive human prostate cancer cells displaying aberrantly high PKCα expression. IHC analysis showed abnormal upregulation of PKCα in human primary prostate tumors. Interestingly, silencing PKCα expression from aggressive prostate cancer cells impairs cell-cycle progression, proliferation, and invasion, as well as their tumorigenic activity in a mouse xenograft model. Mechanistic analysis revealed that PKCα exerts a profound control of gene expression, particularly over genes and transcriptional networks associated with cell-cycle progression and E2F transcription factors. PKCα RNAi depletion from PC3 prostate cancer cells led to a reduction in the expression of proinflammatory cytokine and epithelial-to-mesenchymal transition (EMT) genes, as well as a prominent downregulation of the immune checkpoint ligand PD-L1. This PKCα-dependent gene expression profile was corroborated in silico using human prostate cancer databases. Our studies established PKCα as a multifunctional kinase that plays pleiotropic roles in prostate cancer, particularly by controlling genetic networks associated with tumor growth and progression. The identification of PKCα as a protumorigenic kinase in human prostate cancer provides strong rationale for the development of therapeutic approaches toward targeting PKCα or its effectors.Significance:PKCα was found to be aberrantly expressed in human prostate cancer. Silencing the expression of this kinase from aggressive prostate cancer cell lines reduces their proliferative, tumorigenic, and invasive properties. In addition, our findings implicate PKCα as a major node for transcriptional regulation of tumorigenic, inflammatory, and EMT networks in prostate cancer, highlighting its potential relevance as a therapeutic target.
FAIREST: A Framework for Assessing Research Repositories
Authors: d'Aquin Mathieu , Kirstein Fabian , Oliveira Daniela , Schimmler Sonja , Urbanek Sebastian 
Published: September 2022

ABSTRACTThe open science movement has gained significant momentum within the last few years. This comes along with the need to store and share research artefacts, such as publications and research data. For this purpose, research repositories need to be established. A variety of solutions exist for implementing such repositories, covering diverse features, ranging from custom depositing workflows to social media-like functions.In this article, we introduce the FAIREST principles, a framework inspired by the well-known FAIR principles, but designed to provide a set of metrics for assessing and selecting solutions for creating digital repositories for research artefacts. The goal is to support decision makers in choosing such a solution when planning for a repository, especially at an institutional level. The metrics included are therefore based on two pillars: (1) an analysis of established features and functionalities, drawn from existing dedicated, general purpose and commonly used solutions, and (2) a literature review on general requirements for digital repositories for research artefacts and related systems. We further describe an assessment of 11 widespread solutions, with the goal to provide an overview of the current landscape of research data repository solutions, identifying gaps and research challenges to be addressed.
Nietzsche and the Self-Overcoming of Historical Consciousness
Authors: Winfree Jason Kemp 
Published: September 2022

Abstract
This paper addresses the self-overcoming of historical consciousness in Nietzsche’s “The Uses and Disadvantages of History for Life” and contemporaneous texts. I argue that Nietzsche’s particular historical awareness, which conditions his treatment of historiography [Historie], is indebted to the lineage of German Idealism it also overtly contests. That contestation reaches its apex in Nietzsche’s valorization of appearance and the redirection of poietic power, which enables him to affirm an art of history rather than a science thereof, indeed, an art aligned with justice.
Toward a Phenomenology of “The Other World”: This World as It Is for No One in Particular
Authors: Hayes Shannon 
Published: September 2022

Abstract
In the working notes to The Visible and the Invisible, Merleau-Ponty uses punctum caecum (physiological blind spot) as a metaphor for the unconscious and the invisible of the visible. I read the punctum caecum alongside Merleau-Ponty’s call in another working note to “[e]laborate a phenomenology of the other world.” I take up a phenomenology of the other world as directed toward the punctum caecum of this world. I begin with a discussion of Merleau-Ponty’s unconscious and continue its unfinished thought by drawing in other iterations of the punctum caecum – the involuntary memories in Marcel Proust’s, In Search of Lost Time, the punctum Roland Barthes finds in Camera Lucida and in words that refer to other worlds. Among Merleau-Ponty, Proust, and Barthes I sense something shared – a latent intentionality, and a question about mourning expressed across their disparate texts: the other who existed once, do they exist still? The other who looked at me once, do they look at me still?
Taxonomy of Diamesa steinboecki group (Diptera: Chironomidae: Diamesinae), with description and DNA barcoding of known species. II. Subgroups davisi, leona and loeffleri
Authors: MAKARCHENKO EUGENYI A. , SEMENCHENKO ALEXANDER A. , PALATOV DMITRY M. 
Published: September 2022

Illustrated redescription of the adult males Diamesa alpina Tokunaga from the Russian Far East and North America, D. amplexivirilia Hansen from Arctic and the Russian Far East, D. saetheri Willassen from Chukotka Region and Kolyma River basin, D. lupus Willassen from Alaska, D. serratosioi Willassen from Norway and Russian Far East, D. leoniella Hansen from Alaska, D. leona Roback from Eurasia, D. japonica Tokunaga from Japan and Russian Far East, D. khumbugelida Saether et Willassen and D. loeffleri Reiss from Himalayas are provided.
Morphological data and DNA sequences of the mitochondrial cytochrome c oxidase subunit I gene (COI) were used to delimit of seven species from subgroups davisi (D. alpina, D. amplexivirilia, D. serratosioi), leona (D. japonica, D. leona) and loeffleri (D. khumbugelida, D. loeffleri). Taxonomic remarks with data on geographical distribution of the investigated species are given.
Cochlear Implant Salvage in Case of Grounding Wire Extrusion
Authors: Behnke John , Williamson Adrian , Castaño Johnathan E. 
Published: September 2022

Objectives: Cochlear implantation (CI) is a safe and effective procedure for hearing rehabilitation, with few major complications. Device exposure or extrusion is a rare but major complication that often necessitates explantation due to wound dehiscence or infection. The objective of this report is to present a previously undescribed case in which the cochlear implant grounding wire extruded in 16-month-old patient 3 months post-operatively in the absence of trauma or infection. Methods: We reviewed the case report and the pertinent literature. Results: A 16-month old male suffered extrusion of his left cochlear implant grounding wire without known etiology 86 days post-operatively after bilateral cochlear implantation. The patient was taken for surgery, and the electrode was reimplanted without complication followed by 48 hours of prophylactic intravenous antibiotics. Nine month follow up revealed the implant functioning appropriately, with no further major complications encountered. Conclusion: We present this unique case to demonstrate that a cochlear implant grounding wire extrusion is not necessarily an indication for explantation in the absence of infection.
The Impact of Offering Baccalaureate Degrees on Institutional Enrollment in Community Colleges
Authors: Wright-Kim Jeremy 
Published: September 2022

Objective:The community college sector plays a vital role in broadening access to education and helping states meet their workforce needs. An emerging trend and potential lever to better achieve these goals is the community college baccalaureate or CCB. Yet, opponents wonder whether CCBs may lead community colleges to abandon their traditional logics. This study attempts to help address this question.Methods:Using institution-level panel data, I employ various difference-in-difference approaches to estimate the impact of CCB adoption on overall enrollment levels, as well as the enrollment of historically underrepresented student populations.Results:I find that CCB adoption leads to significant increases in overall student enrollment; these results are robust to alternative specifications and control groups. Yet, enrollment-related impacts vary by selected student populations. I find no consistent evidence that CCB adoption shifts community colleges away from their commitment to underrepresented students, though there may be a tipping point not yet reached by current levels of CCB adoption.Contributions:These findings have important implications for policy and practice as institutional leaders and policy makers continue to debate, adopt, and implement baccalaureate programing at the community college level.
Current Practices for Genetic Testing in Neonatal Extracorporeal Membrane Oxygenation: Findings from a National survey
Authors: Wild K. Taylor , Miquel-Verges Franscesca , Rintoul Natalie E , DiGeronimo Robert , Keene Sarah , Hamrick Shannon E , Mahmood Burhan , Rao Rakesh , Carr Nicholas R ,   Children’s Hospitals Neonatal Consortium (CHNC)
Published: September 2022

Introduction: Comprehensive genetic testing with whole-exome (WES) or whole-genome (WGS) sequencing facilitates diagnosis, can optimize treatment, and may improve outcomes in critically ill neonates, including those requiring extracorporeal membrane oxygenation (ECMO) for respiratory failure. Our objective was to describe practice variation and barriers to the utilization of comprehensive genetic testing for neonates on ECMO. Methods: We performed a cross-sectional survey of Level IV neonatal intensive care units in the United States across the Children’s Hospitals Neonatal Consortium (CHNC). Results: Common indications for WES and WGS included concerning phenotype, severity of disease, unexpected postnatal clinical course, and inability to wean from ECMO support. Unexpected severity of disease on ECMO was the most common indication for rapid genetic testing. Cost of utilization was the primary barrier to testing. If rapid WES or WGS were readily available, 63% of centers would consider incorporating universal screening for neonates upon ECMO cannulation. Conclusion: Despite variation in the use of WES and WGS, universal testing may offer earlier diagnosis and influence the treatment course among neonates on ECMO. Cost is the primary barrier to utilization and most centers would consider incorporating universal screening on ECMO if readily available.
Antidiabetic effects of nerolidol through promoting insulin receptor signaling in high-fat diet and low dose streptozotocin-induced type 2 diabetic rats
Authors: Jiang Nengmei , Zhang Yuanyuan 
Published: September 2022

The present study was designed to investigate the antidiabetic effect of nerolidol on high-fat diet and streptozotocin-induced diabetic rats. Type 2 diabetes was induced in animals by feeding them a high-fat diet for 4 weeks and administering a single intraperitoneal dose of streptozotocin (35 mg/kg body weight). Diabetic rats were treated with nerolidol (25 mg/kg BW) for 28 days. Results showed that nerolidol treatment significantly reduced ( p < 0.05) the level of elevated glucose, glycosylated hemoglobin and improved ( p < 0.05) the body weight and insulin level. Nerolidol also considerably improved ( p < 0.05) the carbohydrate metabolic enzyme activities and increased the glycogen storage in the liver of diabetic rats. Increased serum triglycerides, total cholesterol (C), low-density lipoproteins-C and very low-density lipoproteins-C levels were significantly lowered ( p < 0.05), while reduction of serum high-density lipoprotein-C was alleviated after administration of nerolidol. In addition, nerolidol attenuated oxidative stress markers by significantly increasing ( p < 0.05) the levels of superoxide dismutase, catalase, reduced glutathione, and lowering ( p < 0.05) the level of thiobarbituric acid reactive substances, and lipid hydroperoxide. Similarly, nerolidol showed its pharmacological effects against hepatic markers via restoring ( p < 0.05) the alleviated level of alanine transaminase, aspartate aminotransferase, and alkaline phosphatase. Finally, it improved insulin-dependent glucose transport in skeletal muscle by enhancing and activating glucose transporter protein-4. These findings confirmed the antidiabetic potential of nerolidol in type 2 diabetic rats. This may be related to a high antioxidant capacity, the restoration of plasma insulin and lipid levels, and the activation of insulin signaling in STZ/HFD-induced diabetic rats.
The effects of drilling parameters on thrust force, temperature and hole quality of glass fiber reinforced polymer composites
Authors: Malik Khurshid , Ahmad Faiz , Keong Woo Tze , Gunister Ebru 
Published: September 2022

This paper presents an investigation of the drilling performance of glass fiber reinforced polymer (GFRP) composite based on the thrust force, temperature, and delamination factor (at entry and exit of the hole). High-speed steel (HSS), solid carbide (SC), and solid carbide Balinit® Helica coated (SCBH) twist tools were used for the drilling process. Other drilling parameters were high spindle speeds (12,000, 15,000, and 18,000 rpm), feed rate (300, 500, and 700 mm/min), and laminate thickness (3, 5, and 7 mm). ANOVA and response surface methodology were developed to examine the drilling process based on input and output parameters. Results showed that delamination was observed in the form of matrix debonding, uncut fibers, and fiber pull-out. The best drilling performance was achieved by the SC and SCBH tool at a low feed rate (300 rpm) and high speed (18,000 rpm), and high laminate thickness (7 mm).
Prognostic Values From Integrated Analysis of the Nomogram Based on RNA-Binding Proteins and Clinical Factors in Endometrial Cancer
Authors: Yuan Shuang , Sun Xiao , Wang Lihua 
Published: September 2022

Background: Endometrial cancer (EC) is a common gynecological malignancy, and the prognosis of advanced EC is unsatisfactory. The deregulated expression of RNA-binding proteins (RBPs) is closely associated with the occurrence and development of cancer. However, the role of RBPs in EC remains unclear. The aim of this study was to validate the prognostic values of RBPs combined with clinical factors. Methods: We downloaded the RNA sequencing and clinical data for EC from The Cancer Genome Atlas (TCGA) database. R software was used to identify the differentially expressed RBPs. Univariate and multivariate Cox proportional hazards regression analyses were performed to predict the 4 overall survival (OS)-related RBPs. We then constructed a nomogram combining the 4-RBP signature with clinical risk factors to assess the prognostic power. Furthermore, we validated the expression of 4 RBPs in our patient samples using quantitative real-time polymerase chain reaction (qRT-PCR) and explored the effect of cold-inducible RNA-binding protein (CIRBP) on EC tumor growth using cell proliferation experiments. Results: It is found that Shwachman-Bodian-Diamond syndrome (SBDS), CIRBP, MRPL15, and CELF4 were significantly related to the prognosis of EC patients. In addition, the nomogram showed better performance in OS predictions than the International Federation of Gynecology and Obstetrics (FIGO) stage. The qRT-PCR results showed that low CIRBP expression was associated with cell proliferation. Conclusions: In our study, we constructed a 4-RBP signature-based nomogram combined with clinical factors in EC that could effectively predict the prognosis of EC patients. The results provide novel insights into the development of treatment targets and prognostic molecular markers in EC.
Nurturing patriotism and national pride: An ethnographic exploration into the everyday worlds of Yekolo temari in Washera Qenie School
Authors: Kassa Taglo 
Published: September 2022

Anchored in an ethnographic fieldwork in rural Ethiopia, involving 66 children (12–18 years old) and 17 church scholars, this article looks at how a traditional school of the Ethiopian Orthodox Church nurtures sentiments of patriotism and national pride in Yekolo temari (children in the school). The findings revealed a multitude of pedagogical approaches that the church school employed. The school system also provided the students with ample cultural resources that enhance their national pride and patriotic feeling. This research has practical implications and contributes to the literature on national identity (re)construction, specifically on ways of cultivating patriotism and national pride among schoolchildren.
The Choice of Osteosynthesis for Distal Radius Fractures: A Matter of Taste, Fracture Instability, or Patient-Related Factors? A Retrospective Study of Functional Outcome in 346 Distal Radius Fractures Operated With Percutaneous Wires or Volar Plate Fixation
Authors: Holmqvist Karl-Johan , Johnson Ted , Fornander Lotta 
Published: September 2022

Background: Surgery with volar locking plate (VLP) for distal radius fractures (DRFs) has become dominant over percutaneous Kirschner wire (K-wire) (PKW) fixation. Not many studies have proved advantages of the VLP and the increasing dominance of the VLP is thus not derived from evidence of superiority but influenced by other factors. Methods: By retrospectively classifying 346 DRFs treated with either PKW or VLP fixation, according to the Buttazzoni classification system, we aimed to investigate the determining factors for choice of surgical method, and by review of the patients’ medical records, the functional outcome, duration, and frequentness of the rehabilitation period were correlated to Buttazzoni type and surgical method. Results: The odds ratio of having volar plate fixation was negatively correlated to age and positively correlated to a higher Buttazzoni type. We found no clinically significant differences in the functional outcome for different Buttazzoni type of fractures within the VLP and PKW groups, respectively, nor between the 2 methods of surgery for any Buttazzoni type of fracture. Conclusion: Younger patients and fractures with higher grade of instability were more likely to be treated with VLP than PKW; however, neither fracture instability nor surgical method had any impact on functional outcome.
Complications Following Ulnar Artery Catheterization for Coronary Angiography
Authors: Grasso Mackenzie B. , McLaughlin Jillian , Amendola Michael F. , Cotterell Ilvy H. F. 
Published: September 2022

Background: Use of radial and ulnar access has increased due to its perceived benefits over femoral access. Ulnar artery catheterization can place patients at risk of significant complications, including pseudoaneurysm, expanding hematoma, compartment syndrome, ulnar nerve injury, and critical hand ischemia. The purpose of this study was to describe complications specific to ulnar artery catheterization. Methods: After obtaining institutional review board approval, a retrospective review was performed on all patients who underwent ulnar artery catheterization at our institution between 2019 and 2021. Complications were assessed, and complication rates were compared with previously published studies on ulnar artery catheterization for coronary angiography (percutaneous coronary intervention). Results: A total of 41 patients were available for review with a mean age of 59 years. Of these, 17 patients (41%) sustained complications in the immediate postprocedural period. These complications included hematoma (12 patients, 29%), pseudoaneurysm (1 patient, 2%), ulnar artery thrombosis (1 patient, 2%), ulnar neuropathy (3 patients, 7%), arterial damage requiring repair (2 patients, 5%), transient ischemia (3 patients, 7%), and compartment syndrome (2 patients, 5%). Three of these patients (7%) required operative intervention, and several were admitted to the hospital for an additional period of observation. Conclusions: This series highlights the significant risks associated with ulnar artery catheterization for percutaneous procedures. Complications include pseudoaneurysm, expanding hematoma, compartment syndrome, ulnar nerve damage, and critical hand ischemia. Several of these patients required urgent or emergent surgical intervention, with some patients experiencing ongoing ulnar nerve symptoms.