bluuebunny/crossref_metadata_2025_split huggingface dataset:
TDP‐43 Pathology Exacerbates Cognitive Decline in Primary Age‐Related Tauopathy
Authors: Smirnov Denis S. , Salmon David P. , Galasko Douglas , Edland Steven D. , Pizzo Donald P. , Goodwill Vanessa , Hiniker Annie 
Published: June 2022

ObjectivePrimary age‐related tauopathy (PART) refers to tau neurofibrillary tangles restricted largely to the medial temporal lobe in the absence of significant beta‐amyloid plaques. PART has been associated with cognitive impairment, but contributions from concomitant limbic age‐related TDP‐43 encephalopathy neuropathologic change (LATE‐NC) are underappreciated.MethodsWe compare prevalence of LATE‐NC and vascular copathologies in age‐ and Braak‐matched patients with PART (n = 45, Braak stage I–IV, Thal phase 0–2) or early stage Alzheimer disease neuropathologic change (ADNC; n = 51, Braak I–IV, Thal 3–5), and examine their influence on clinical and cognitive decline.ResultsConcomitant LATE‐NC and vascular pathology were equally common, and cognition was equally impaired, in PART (Mini‐Mental State Examination [MMSE] = 24.8 ± 6.9) and ADNC (MMSE = 24.2 ± 6.0). Patients with LATE‐NC were more impaired than those without LATE‐NC on the MMSE (by 5.8 points, 95% confidence interval [CI] = 3.0–8.6), Mattis Dementia Rating Scale (DRS; 17.5 points, 95% CI = 7.1–27.9), Clinical Dementia Rating, sum of boxes scale (CDR‐sob; 5.2 points, 95% CI = 2.1–8.2), memory composite (0.8 standard deviations [SD], 95% CI = 0.1–1.6), and language composite (1.1 SD, 95% CI = 0.2–2.0), and more likely to receive a dementia diagnosis (odds ratio = 4.8, 95% CI = 1.5–18.0). Those with vascular pathology performed worse than those without on the DRS (by 10.2 points, 95% CI = 0.1–20.3) and executive composite (1.3 SD, 95% CI = 0.3–2.3). Cognition declined similarly in PART and ADNC over the 5 years preceding death; however, LATE‐NC was associated with more rapid decline on the MMSE (β = 1.9, 95% CI = 0.9–3.0), DRS (β = 7.8, 95% CI = 3.4–12.7), CDR‐sob (β = 1.9, 95% CI = 0.4–3.7), language composite (β = 0.5 SD, 95% CI = 0.1–0.8), and vascular pathology with more rapid decline on the DRS (β = 5.2, 95% CI = 0.6–10.2).InterpretationLATE‐NC, and to a lesser extent vascular copathology, exacerbate cognitive impairment and decline in PART and early stage ADNC. ANN NEUROL 2022;92:425–438
Medium Diradical Character, Small Hole and Electron Reorganization Energies and Ambipolar Transistors in Difluorenoheteroles
Authors: Mori Sakura , Moles Quintero Sergio , Tabaka Naoki , Kishi Ryohei , González Núñez Raúl , Harbuzaru Alexandra , Ponce Ortiz Rocío , Marín‐Beloqui Jose , Suzuki Shuichi , Kitamura Chitoshi , Gómez‐García Carlos J. , Dai Yasi , Negri Fabrizia , Nakano Masayoshi , Kato Shin‐ichiro , Casado Juan 
Published: June 2022

AbstractFour difluorenoheteroles having a central quinoidal core with the heteroring varying as furan, thiophene, its dioxide derivative and pyrrole have shown to be medium character diradicals. Solid‐state structures, optical, photophysical, magnetic, and electrochemical properties have been discussed in terms of diradical character, variation of aromatic character and captodative effects (electron affinity). Organic field‐effect transistors (OFETs) have been prepared, showing balanced hole and electron mobilities of the order of 10−3 cm2 V−1 s−1 or ambipolar charge transport which is first inferred from their redox amphoterism. Quantum chemical calculations show that the electrical behavior is originated from the medium diradical character which produces similar reorganization energies for hole and electron transports. The vision of a diradical as simultaneously bearing pseudo‐hole and pseudo‐electron defects might justify the reduced values of reorganization energies for both regimes. Structure‐function relationships between diradical and ambipolar electrical behavior are revealed.
Nickel‐Catalyzed Four‐Component Carbonylation of Ethers and Olefins: Direct Access toγ‐Oxy Esters and Amides
Authors: Wang Le‐Cheng , Chen Bo , Zhang Youcan , Wu Xiao‐Feng 
Published: June 2022

AbstractMulti‐component carbonylation of olefins, a reaction that installs both a carbon–carbon(heteroatom) bond and a carbonyl group across the double bond, is an attractive strategy for alkene functionalization. Herein, we developed a novel nickel‐catalyzed four‐component carbonylation of olefins with ethers under low CO gas pressure. Using alcohols and amines as the reaction partner, diverseγ‐oxy‐substituted esters and amides were produced in good yields with excellent functional group tolerance. Notably, Naftidrofuryl, a medicine for the treatment of cerebrovascular disease (CVD), can be synthesized by this process straightforwardly.
Suppression of Chain Transfer at High Temperature in Catalytic Olefin Polymerization
Authors: Hu Xiaoqiang , Kang Xiaohui , Jian Zhongbao 
Published: June 2022

AbstractLiving polymerization by suppressing chain transfer is a very useful method for achieving precise molecular weight and structure control. However, the suppression of chain transfer at high temperatures is extremely challenging in any catalytic polymerization. This has been a severe limitation for catalytic olefin polymerization, which is one of the most important chemical reactions. Here, we report the unprecedented living polymerization of ethylene at 130 °C, with a narrow molecular weight distribution range of 1.04 to 1.08. This is a significant increase in the reaction temperature. Tailor‐made α‐diimine nickel catalysts that exhibit both the steric shielding and fluorine effects play an essential role in this breakthrough. These nickel catalysts are even active at 200 °C, and enable the formation of semi‐crystalline, ultrahigh‐molecular‐weight polyethylene at 150 °C. Mechanistic insights into the key chain transfer reaction are elucidated by density functional theory calculations.
Neuro‐immune interactions and the role of Mas‐related G protein‐coupled receptors in the gastrointestinal tract
Authors: Van Remoortel Samuel , Lambeets Lana , Timmermans Jean‐Pierre 
Published: June 2022

AbstractOver the past decade, the research field dealing with the role of a new family of Rhodopsin A‐like G protein‐coupled receptors, that is, the family of Mas‐related G protein‐coupled receptors (Mrgprs) has expanded enormously. A plethora of recent studies have provided evidence that Mrgprs are key players in itch and pain, as well as in the initiation and modulation of inflammatory/allergic responses in the skin. Over the years, it has become clear that this role is not limited to the skin, but extends to other mucosal surfaces such as the respiratory tract and the gastrointestinal (GI) tract. In the GI tract, Mrgprs have emerged as novel interoceptive sensory pathways linked to health and disease, and are in close functional association with the gut's immune system. This review aims to provide an update of our current knowledge on the expression, distribution and function of members of this Mrgpr family in intrinsic and extrinsic neuro‐immune pathways related to the GI system.
Synthesized nanoliposome‐encapsulated kaempferol attenuates liver health parameters and gene expression in mice challenged by cadmium‐induced toxicity
Authors: Haeri Vahideh , Karimi Ehsan , Oskoueian Ehsan 
Published: June 2022

AbstractIn the present research, we encapsulated a flavonoid called kaempferol into nanoliposomal structures and the health‐promoting effects of synthesized nanoliposome‐loaded kaempferol (NLK) were evaluated in mice challenged by cadmium‐induced . The NLK characteristics, such as size, zeta potential, and polydispersity index, were 218.4 nm, −28.55 mV, and 0.29, respectively. The in vivo experiment revealed that the mice receiving water containing cadmium (2 mg/kg body weight/day) showed significant (p < 0.05) weight loss, an increase in liver enzyme activities, and hepatic oxidative stress. Dietary supplementation with NLK at concentrations of 2.5 and 5 mg/kg mice body weight notably (p < 0.05) improved the body weight, liver enzyme activities, hepatic oxidative stress, and antioxidant potential of the liver. Our findings elucidated that NLK could alleviate the toxicity of cadmium in mice challenged by cadmium‐induced toxicity.
Evaluating glioma‐associated microRNA by complementation on a biological nanosensor
Authors: Li Zizhuo , Wan Xin , Li Mingming , He Qiuxia , Yang Haichao , Zhang Wei , Yang Xiuhua 
Published: June 2022

AbstractGlioma is a tumor in the brain and spinal cord originating in the glial cells that surround the nerve cells. Among several microRNAs reported, miRNA‐363 is associated with human glioma. Based on miRNA‐363 levels, the development and progression of glioma can be monitored. The current study used an interdigitated electrode sensor to monitor microRNA‐363 levels, which indeed reflects the severity of glioma. The interdigitated electrode was generated using a photolithography technique followed by surface chemical modification carried out to insert miRNA‐363 complementary oligo as the probe complexed with gold nanoparticles. The proposed sensor works based on the dipole moment between two electrodes, and when molecular immobilization or interaction occurs, the response by the signal output changes. The changes in the target microRNA‐363 sequence were standardized to identify glioma. The limit of detection of miRNA‐363 was 10 fM with anR2value of 0.996 on the linear coefficient regression ranges between 1 fM and 100 pM. Furthermore, unrelated sequences failed to increase the response of the current with the complementary probe, indicating specific miRNA‐363 detection on the interdigitated electrode. This study demonstrates the platform to be used for determining the presence of microRNA‐363 in glioma and as the basis for other biomarker analyses.
Responses to prenatal opioid and alcohol abuse: A review of US and Australian mandatory reporting laws
Authors: Kenny Maureen C. , Mathews Ben , Pathirana Maheshi 
Published: June 2022

AbstractPrenatal substance use, specifically opioid and excessive alcohol use, can cause significant adverse effects for the unborn foetus in both the short‐and long‐term. Responses by state social systems occur on a spectrum of prevention and early intervention to support mothers. Some but not all states include reporting duties, so that professionals made aware of the situation may alert agencies that can intervene to provide appropriate support. This article will review legal duties to report maternal substance use during pregnancy in the US and Australia. We identify variations in these laws regarding who is required to report, what circumstances must be reported and what indicates child abuse or neglect. Inconsistencies in laws raise questions about the nature of different approaches, and how reforms might be made to improve provision of support. Informed by the medical literature, the contemporary context and federal policy in the US, we make recommendations for reform, and for the appropriate response to such reports.
Lignin Nanoparticles Support Lipase‐Tyrosinase Enzymatic Cascade in the Synthesis of Lipophilic Hydroxytyrosol Ester Derivatives
Authors: Tomaino Elisabetta , Capecchi Eliana , Piccinino Davide , Saladino Raffaele 
Published: June 2022

AbstractLipophilic esters of hydroxytyrosol have been synthesized in a one‐pot procedure from tyrosol and long side‐chain carboxylic acids by a lignin nanoparticles supported enzymatic cascade of lipase M and tyrosinase. The reaction involved the initial esterification of the aliphatic carboxylic group with the hydroxyl group of tyrosol followed by ortho‐hydroxylation of the aromatic moiety. Lipase M and tyrosinase were immobilized on lignin nanoparticles by layer‐by‐layer procedure using chitosan as positive charged polyelectrolyte and Concanavalin A as molecular spacer to control the optimal distance between the active sites of the two enzymes. The occurrence of substrate channeling effect was hypothesized on the basis of FRET analysis. Lipophilic hydroxytyrosol esters were synthesized in high yield in 2‐methyltetrahydrofuran and in the presence of a very low amount of buffer to generate the hydration sphere of the enzyme.
Precisely Tuning the Surface Nanostructure of Ni@Pd Nanocatalysts for Enhanced Formic Acid Oxidation
Authors: Li Xiang , Zhang Junjun , Dou Jingjing , Li Mengyang , Feng Xiaohua , Liu Ge 
Published: June 2022

AbstractConstructing Ni@Pd nanocatalysts can effectively improve the catalytic efficiency of Pd atoms. However, it is difficult to grow Pd atoms uniformly on the Ni surface due to the large lattice mismatch between Ni and Pd. Herein, we demonstrate that the well‐defined Ni@Pd nanocatalysts can be obtained by the galvanic replacement reaction between Ni and Pd at room temperature. By simply regulating the content of Pd precursor in the galvanic replacement reaction, the atomic percentages of Pd can be controlled from 2 % to 9 %. In synthesized Ni@Pd nanocatalysts, the Ni@Pd0.06 core‐shell nanocrystals show the highest mass activity (1186 mA mgPd−1) and specific activity (4.21 mA cm−2), which are 5.6 times and 2.6 times higher than that of the commercial Pd/C nanocatalyst (212 mA mgPd−1, 1.60 mA cm−2). The enhanced performance is mainly attributed to the synergistic effect between Pd and Ni and the core‐shell nanostructure.
Effect of Hydrothermal Carbonization Parameters and Performance of Carbon Dioxide Adsorption on Pineapple Peel Waste Biochar
Authors: Ibrahim Muthmirah , Hameed Bassim H. , Ouakouak Abdelkader , Mohd Din Azam Taufik 
Published: June 2022

AbstractLow‐cost biochar adsorbents were prepared from pineapple peel waste (PPW) via hydrothermal carbonization (HTC) for CO2 capture. The effects of hydrothermal carbonization temperature, retention time, and heating rate were studied. The hydrochar samples were further carbonized to produce pineapple peel biochar adsorbents. The effects of CO2 concentration in the feed, adsorption temperature, and feed flow rate on adsorption capacity were investigated in a fixed‐bed column adsorption system. The experimental data were analyzed using pseudo‐first‐order and pseudo‐second‐order kinetics, and the Avrami equation. The CO2 adsorption capacity of this system was improved with increasing CO2 feed concentration and decreased with rising temperature and feed flow rate. The Avrami kinetics model was best fitted to the experimental data. The CO2 adsorption performance of PPW biochar (PPW‐BC) in a fixed‐bed column was successfully predicted by the Thomas and Yoon‐Nelson models. The prepared PPW‐BC adsorbents could be a viable option for CO2 capture because they were synthesized from a low‐cost biomass source and are environmentally benign.
Cyanoethyl cellulose‐based eutectogel electrolyte enabling high‐voltage‐tolerant and ion‐conductive solid‐state lithium metal batteries
Authors: Zhang Hao , Zhou Lixue , Du Xiaofan , Zhang Jianjun , Tian Songwei , Liu Tingting , Zhang Jinning , Hu Sijia , Song Weiling , Zhou Xinhong , Cui Guanglei 
Published: June 2022

AbstractSolid‐state polymer electrolytes are an important factor in the deployment of high‐safety and high‐energy‐density solid‐state lithium metal batteries. Nevertheless, use of the traditional polyethylene oxide‐based solid‐state polymer electrolyte is limited due to its inherently low ionic conductivity and narrow electrochemical stability window. Herein, for the first time, we specifically designed a cyanoethyl cellulose‐in‐deep eutectic solvent composite eutectogel as a promising candidate for hybrid solid‐state polymer electrolytes. It is found that the proposed eutectogel electrolyte achieves high ionic conductivity (1.87 × 10−3 S cm−1 at 25°C), superior electrochemical stability (up to 4.8 V), and outstanding lithium plating/striping behavior (low overpotential of 0.04 V at 1 mA cm−2 and 1 mA h cm−2 over 300 h). With the eutectogel‐based solid‐state polymer electrolyte, a 4.45 V LiCoO2/Li metal battery delivers prominent long‐term lifespan (capacity retention of 85% after 200 cycles) and high average Coulombic efficiency (99.5%) under ambient conditions, significantly outperforming the traditional carbonate‐based liquid electrolyte. Our work demonstrates a promising strategy for designing eutectogel‐based solid‐state polymer electrolytes to realize high‐voltage and high‐energy lithium metal batteries.
Phosphorescence Induction by Host‐Guest Complexation with Cyclodextrins – The Role of Regioisomerism and Affinity
Authors: Hayduk Matthias , Schaller Torsten , Niemeyer Felix C. , Rudolph Kevin , Clever Guido H. , Rizzo Fabio , Voskuhl Jens 
Published: June 2022

AbstractWe present an in‐depth investigation of cyclodextrin complexes with guest compounds featuring complexation‐induced room temperature phosphorescence (RTP) in aqueous solution. Very interestingly, only the complexed regioisomers bearing lateral substituents on meta‐position show RTP, whereas the stronger host‐guest systems with para‐substituted dyes show no RTP features. The reported systems were investigated regarding their complexation behavior in water using isothermal titration calorimetry and mass spectrometry. In the case of γ‐CD very strong 1 : 1 inclusion complexes (Kaup to 5.13×105 M−1) were unexpectedly observed. It was found that not only a strong binding to the cyclodextrin cavity is needed to restrict motion, inducing the emission, but also the conformation inside the cavity plays a pivotal role – as supported by an extensive NMR study and MD simulations.
Chemically Laminated 2D Bis(terpyridine)metal Polymer Films: Formation Mechanism at the Liquid–Liquid Interface and Redox Rectification
Authors: Komeda Joe , Takada Kenji , Maeda Hiroaki , Fukui Naoya , Tsuji Takuya , Nishihara Hiroshi 
Published: June 2022

AbstractRecent studies on molecular 2D materials with high tunability of structure and function have focused mostly on the discovery of new precursors. Here, we demonstrate a facile one‐pot synthesis of laminated 2D coordination polymer films comprising bis(terpyridine)iron and cobalt at a water/dichloromethane interface. Cross‐sectional elemental mapping unveiled the stratum‐like structure of the film and revealed that the second layer grows to the dichloromethane side below the first layer. Cyclic voltammetry clarified that the bottom layer mediates charge transfer between the top layer and the substrate in a narrow potential region of mixed‐valence states. Furthermore, the bilayer film sandwiched by electrodes in a dry condition shows stable rectification character, and the barrier voltage corresponds to the redox potential difference between the two layers. This study introduces a new strategy for polymer design to explore the materials science of molecular 2D materials.
Design, Synthesis and Characterization of a Visible‐Light‐Sensitive Molecular Switch and Its PEGylation Towards a Self‐Assembling Molecule
Authors: Paolino Marco , Saletti Mario , Reale Annalisa , Licciardi Mariano , Varvarà Paola , Marquette Arnaud , Léonard Jérémie , Bonechi Claudia , Donati Alessandro , Giorgi Gianluca , Giuliani Germano , Carlotti Benedetta , Ortica Fausto , Latterini Loredana , Gentile Mariangela , Paccagnini Eugenio , Olivucci Massimo , Cappelli Andrea 
Published: June 2022

AbstractHBDI‐like chromophores represent a novel set of biomimetic switches mimicking the fluorophore of the green fluorescent protein that are currently studied with the hope to expand the molecular switch/motor toolbox. However, until now members capable of absorbing visible light in their neutral (i. e. non‐anionic) form have not been reported. In this contribution we report the preparation of an HBDI‐like chromophore based on a 3‐phenylbenzofulvene scaffold capable of absorbing blue light and photoisomerizing on the picosecond timescale. More specifically, we show that double‐bond photoisomerization occurs in both the E‐to‐Z and Z‐to‐E directions and that these can be controlled by irradiating with blue and UV light, respectively. Finally, as a preliminary applicative result, we report the incorporation of the chromophore in an amphiphilic molecule and demonstrate the formation of a visible‐light‐sensitive nanoaggregated state in water.
Fine‐Tuning of Structural Distortion and Magnetic Anisotropy by Organosulfonates in Octahedral Cobalt(II) Complexes
Authors: Shao Dong , Xu Fang‐Xue , Yin Lei , Li Hong‐Qing , Sun Yu‐Chen , Ouyang Zhong‐Wen , Wang Zhen‐Xing , Zhang Yi‐Quan , Wang Xin‐Yi 
Published: June 2022

Comprehensive SummaryPrecise modulation of the magnetic anisotropy of metal ions remains highly important for the development of high–performance single‐molecule magnets (SMMs). We herein reported the synthetic, structural, spectral, magnetic, and computational studies on four mononuclear CoII complexes in a distorted octahedral environment. The change of the organosulfonate anions triggers significant modification of the distorted octahedral CoN6 coordination sphere, which enables us to tackle the influence of the structural distortion on the magnetic anisotropy in these complexes. Magnetic measurements revealed that the four complexes possess easy–plane magnetic anisotropy with large and positive zero‐field splitting parameters, which decrease with the increasing distortion of the pseudo–octahedral CoII coordination geometry. This correlation was further confirmed by high–frequency/–field EPR (HF–EPR) spectra and theoretical calculations. Dynamic magnetic susceptibility measurements indicate that these complexes both exhibit slow magnetic relaxation under an external dc field, indicating the field‐induced single‐ion magnets (SIMs) of the four complexes. These results indicate that structural distortion plays an important role in the magnetic anisotropy of CoII complexes and should be carefully considered in the design of molecular complexes with high magnetic anisotropy.
Systematic Exploration of Passive Permeability in Tetrapeptides with Hydrogen‐Bond‐Accepting Amino Acid Side Chains
Authors: Shimizu Hiroki , Renslo Adam R. 
Published: June 2022

AbstractWe synthesized and experimentally tested the passive permeability of more than thirty tetrapeptides mimicking the N‐terminus of the pro‐apoptotic protein Smac (Second mitochondria‐derived activator of caspases). Each peptide bore one or two unnatural Hydrogen Bond Acceptor‐bearing Amino Acid (HBA‐AA) residues, such that intramolecular hydrogen bonding with proximal backbone amide N−H donors is feasible. Passive permeability of the synthetic peptides was determined using the parallel artificial membrane permeability assay (PAMPA). Experimental permeability values were found to span three orders of magnitude, providing useful empirical guidance for the design of more permeable Smac mimetics specifically, and peptidic ligands generally.
Class‐index corpus‐index measure: A novel feature selection method for imbalanced text data
Authors: Parlak Bekir 
Published: June 2022

SummaryIn the field of text classification, some of the datasets are unbalanced datasets. In these datasets, feature selection stage is important to increase performance. There are many studies in this area. However, existing methods have been developed based on the document frequency of only intra‐class. In this study, a new method is proposed considering the situation of the feature in class and corpus. A new feature selection method, namely class‐index corpus‐index measure (CiCi) was presented for unbalanced text classification. The CiCi is a probabilistic method which is calculated using feature distribution in both class and corpus. It has shown a higher performance compared to successful methods in the literature. Multinomial Naïve Bayes and support vector machines were used as classifiers in the experiments. Three different unbalanced datasets are used in the experiments. These benchmark datasets are reuters‐21578, ohsumed, and enron1. Experimental results show that the proposed method has more performance in terms of three different success measures.