bluuebunny/crossref_metadata_2025_split huggingface dataset:
LifeSnaps, a 4-month multi-modal dataset capturing unobtrusive snapshots of our lives in the wild
Authors: Yfantidou Sofia , Karagianni Christina , Efstathiou Stefanos , Vakali Athena , Palotti Joao , Giakatos Dimitrios Panteleimon , Marchioro Thomas , Kazlouski Andrei , Ferrari Elena , Girdzijauskas Šarūnas 
Published: October 2022

AbstractUbiquitous self-tracking technologies have penetrated various aspects of our lives, from physical and mental health monitoring to fitness and entertainment. Yet, limited data exist on the association between in the wild large-scale physical activity patterns, sleep, stress, and overall health, and behavioral and psychological patterns due to challenges in collecting and releasing such datasets, including waning user engagement or privacy considerations. In this paper, we present the LifeSnaps dataset, a multi-modal, longitudinal, and geographically-distributed dataset containing a plethora of anthropological data, collected unobtrusively for the total course of more than 4 months by n = 71 participants. LifeSnaps contains more than 35 different data types from second to daily granularity, totaling more than 71 M rows of data. The participants contributed their data through validated surveys, ecological momentary assessments, and a Fitbit Sense smartwatch and consented to make these data available to empower future research. We envision that releasing this large-scale dataset of multi-modal real-world data will open novel research opportunities and potential applications in multiple disciplines.
On the analyses of carbon atom diffused into grey cast iron during carburisation process
Authors: Salawu Enesi Y. , Adediran Adeolu A. , Ajayi Oluseyi O. , Inegbenebor Anthony O. , Dirisu Joseph O. 
Published: October 2022

AbstractThe study employed Fick’s second law of diffusion to discover some unknown aspect of carbon diffusion in grey cast iron during carburisation process. Emphasis on the experiments and theoretical modelling were established for better accomplishments. Pulverised palm kernel and eggshell additives of 70 (wt.%) and 30 (wt.%) according to the Voige law of mixture was considered as a continuous medium without considering the atomic nature of the mixture. Furthermore, a kinetic approach was described where a physical model of the substrate immersed in the carbon mixture was established while diffusion equations were modelled to establish the mechanism of carbon diffusion during carburisation. Initial composition and concentration of diffused atom remained constant which are 2.68 and 6.67% carbon. While the carburizing time used varied from 60 min, 90 min, 120 min, 150 min, 180 min and 210 min respectively at constant carburising temperature of 900° The results revealed varying composition gradient of carbon atom ranging from 5.4%, 5.42%, 5.44%, 5.46%, 5.51%, and 5.65 compared to the initial carbon content of 2.68%. The concentration of carbon atom on the substrate surface at varying time implies that the process was non-steady state diffusion which verified Fick’s second law of diffusion. Hence, the composition achieved is a function of boundary conditions such as time position and temperature. This novel study will enhance the understanding of heat treat treatment of metals such that their applications in the industry will be numerous.
Hypothermia and heart rate variability in a healthy newborn piglet model
Authors: Pedersen Mette Vestergård , Andelius Ted Carl Kejlberg , Andersen Hannah Brogård , Kyng Kasper Jacobsen , Henriksen Tine Brink 
Published: October 2022

AbstractDecreased heart rate variability (HRV) may be a biomarker of brain injury severity in neonatal hypoxic-ischemic encephalopathy for which therapeutic hypothermia is standard treatment. While therapeutic hypothermia may influence the degree of brain injury; hypothermia may also affect HRV per se and obscure a potential association between HRV and hypoxic-ischemic encephalopathy. Previous results are conflicting. This study aimed to investigate the effect of hypothermia on HRV in healthy, anaesthetised, newborn piglets. Six healthy newborn piglets were anaesthetised. Three piglets were first kept normothermic (38.5–39.0 °C) for 3 h, then exposed to hypothermia (33.5–34.5 °C) for 3 h. Three piglets were first exposed to hypothermia for 3 h, then rewarmed to normothermia for 3 h. Temperature and ECG were recorded continuously. HRV was calculated from the ECG in 5 min epochs and included time domain and frequency domain variables. The HRV variables were compared between hypothermia and normothermia. All assessed HRV variables were higher during hypothermia compared to normothermia. Heart rate was lower during hypothermia compared to normothermia and all HRV variables correlated with heart rate. Hypothermia was associated with an increase in HRV; this could be mediated by bradycardia during hypothermia.
Differential expression and regulation of HSP70 gene during growth phase in ruminants in response to heat stress
Authors: Kaushik Rakesh , Goel Anjana , Rout P. K. 
Published: October 2022

AbstractHeat shock proteins regulate the physiological mechanism of heat stress adaptation at cellular level. The present investigation was carried out to analyse the HSP70 gene regulation in various growth stage in ruminants in peripheral blood mononuclear cells (PBMCs). The relationship between HSP gene expression and thermotolerance in age-specific manner in ruminants has not been analysed. Therefore m-RNA HSP70 expression level was examined in different age groups of Jamunpari goat during hot climatic conditions. The experiment was carried out in 32 animals of Jamunapari goat belonging to the age groups of 3-months, 9-months, 12-months, and adults (2–3 year). Total RNA was isolated from peripheral blood mononuclear cells. The physiological response such as rectal temperature (RT), respiration rate (RR) and heart rate (HR) was used as indicator to heat stress. Temperature Humidity Index (THI) was used as an indicator of severity of environmental stress. The THI range varied from 82.00–92.08 during experimental period. The m-RNA HSP70 expression level at 9-month age of animals was up-regulated and significantly higher than other age groups. It was observed that the level of HSP70 transcripts in PBMCs was highest at 9-month age group, and age-related decline in HSP70 expression was observed in adult age. Based on the physiological response, the contrasting heat-stress phenotypes were recognised as heat stress susceptible (HSS) and heat stress tolerant (HST) individuals and the expression of m-RNA HSP70 was analysed at different ages in response to chronic heat stress. The differential mRNA expression of HSS individuals at 3 and 9-month of age showed the highest fold expression than HST. Age and phenotype had significant effect (p < 0.01) on the crossing point (CP) value. The m-RNA HSP70 gene expression in different age groups was correlated with heat stress tolerance and this could be used as biomarker for breeders to analyse the HSP responsein -vivoin ruminants.
Comprehensive single-shot biophysical cytometry using simultaneous quantitative phase imaging and Brillouin spectroscopy
Authors: Steelman Zachary A. , Coker Zachary N. , Sedelnikova Anna , Keppler Mark A. , Kiester Allen S. , Troyanova-Wood Maria A. , Ibey Bennett L. , Bixler Joel N. 
Published: October 2022

AbstractSingle-cell analysis, or cytometry, is a ubiquitous tool in the biomedical sciences. Whereas most cytometers use fluorescent probes to ascertain the presence or absence of targeted molecules, biophysical parameters such as the cell density, refractive index, and viscosity are difficult to obtain. In this work, we combine two complementary techniques—quantitative phase imaging and Brillouin spectroscopy—into a label-free image cytometry platform capable of measuring more than a dozen biophysical properties of individual cells simultaneously. Using a geometric simplification linked to freshly plated cells, we can acquire the cellular diameter, volume, refractive index, mass density, non-aqueous mass, fluid volume, dry volume, the fractional water content of cells, both by mass and by volume, the Brillouin shift, Brillouin linewidth, longitudinal modulus, longitudinal viscosity, the loss modulus, and the loss tangent, all from a single acquisition, and with no assumptions of underlying parameters. Our methods are validated across three cell populations, including a control population of CHO-K1 cells, cells exposed to tubulin-disrupting nocodazole, and cells under hypoosmotic shock. Our system will unlock new avenues of research in biophysics, cell biology, and medicine.
Post-operative prophylactic antibiotics in aseptic revision hip and knee arthroplasty: a propensity score matching analysis
Authors: Kuo Feng-Chih , Chang Yu-Han , Huang Tsan-Wen , Chen Dave Wei-Chih , Tan Timothy L. , Lee Mel S. 
Published: October 2022

AbstractThe use of extended antibiotic (EA) prophylaxis (> 24 h) remains controversial in aseptic revision arthroplasty. We sought to determine whether EA prophylaxis reduces the risk of periprosthetic joint infection (PJI) in aseptic revision hip and knee arthroplasty. A total of 2800 patients undergoing aseptic revision hip and knee arthroplasty at five institutional databases from 2008 to 2017 were evaluated. One to two nearest-neighbor propensity score matching analysis was conducted between patients who did and did not receive extended antibiotic prophylaxis. The matching elements included age, sex, body mass index, Charlson comorbidity index, hospital distribution, year of surgery, joint (hip or knee), surgical time, CRP, preoperative hemoglobin, albumin, and length of stay. The primary outcome was the development of PJI, which was assessed at 30 days, 90 days, and 1 year following revision and analyzed separately. A total of 2467 (88%) patients received EA prophylaxis, and 333 (12%) patients received standard antibiotic (SA) prophylaxis (≤ 24 h). In the propensity-matched analysis, there was no difference between patients who received EA prophylaxis and those who did not in terms of 30-day PJI (0.3% vs. 0.3%, p = 1.00), 90-day PJI (1.7% vs. 2.1%, p = 0.62) and 1- year PJI (3.8% vs. 6.0%, p = 0.109). For revision hip, the incidence of PJI was 0.2% vs 0% at 30 days (p = 0.482), 1.6% vs 1.4% at 90 days (p = 0.837), and 3.4% vs 5.1% at 1 year (p = 0.305) in the EA and SA group. For revision knee, the incidence of PJI was 0.4% vs 0.9% at 30 days (p = 0.63), 1.8% vs 3.4% at 90 days (p = 0.331), and 4.4% vs 7.8% at 1 year (p = 0.203) in the EA and SA group. A post hoc power analysis revealed an adequate sample size with a beta value of 83%. In addition, the risks of Clostridium difficile and resistant organism infection were not increased. This multi-institutional study demonstrated no difference in the rate of PJIs between patients who received extended antibiotic prophylaxis and those who did not in aseptic revision arthroplasty. The risk of C. difficile and resistant organism infection was not increased with prolonged antibiotic use.
MIMO antenna array with the capability of dual polarization reconfiguration for 5G mm-wave communication
Authors: Arshad Farzana , Ahmad Ashfaq , Amin Yasar , Abbasi M. Ali Babar , Choi Dong-you 
Published: October 2022

AbstractThis communication presents a polarization reconfigurable antenna array (PRAA) with Multi-input Multi-output (MIMO) formation for 5th generation (5G) millimeter wave (mm-Wave) communications. At first a single corner curtailed diagonal slotted cylindrical patch is printed on Roger RT Duriod 5880 and the overall size of the single antenna is 12 × 12 × 0.787 mm3. The circular polarization (CP) is realized by adding the diagonal slot in the circular patch. The antenna design is extended into two elements antenna array which occupies 20 × 20 × 0.787 mm3 footprint. The collection is formed using a T-shaped power divider/combiner. Pin-diodes are integrated with the patches to switch the polarization state between LP (Linear polarization) and CP radiation. The edge-to-edge distance between antenna elements is 6 mm. The design covers the 25.2–29.4 GHz band, and the maximum peak gain is 11.5 dBi. Moreover, a two-port (2 × 2) MIMO design is formed to increase the channel capacity. To isolate the ports, a sin-like slot is engraved in the ground, defected ground structure (DGS) technique of mutual coupling reduction; it can easily be implemented and increases the design efficiency. The port isolation is well above 30 dB for the entire operating band. Moreover, the Mean Effective Gain (MEG), Diversity Gain (DG), and Envelope Correlation Coefficient (ECC) are investigated, which are key performance metrics of MIMO. A prototype of the realized MIMO antenna system is fabricated, and the simulated outcomes carried out by Computer Simulation Technology (CST) tools are validated by experimental findings.
Searching for serum biomarkers linking coronary heart disease and Helicobacter pylori infection using infrared spectroscopy and artificial neural networks
Authors: Gonciarz Weronika , Lechowicz Łukasz , Urbaniak Mariusz , Rechciński Tomasz , Chałubiński Maciej , Broncel Marlena , Kaca Wiesław , Chmiela Magdalena 
Published: October 2022

AbstractHelicobacter pylori(Hp) Gram-negative bacteria cause gastritis or gastric ulcers. They may be involved in the development of systemic diseases i.e. coronary heart disease (CHD). Both Hp infection and CHD are related to inflammation accompanied by C-reactive protein (CRP), tumor necrosis factor alfa (TNF-α) and homocysteine. Low density lipoprotein (LDL) and triglicerides are a classic risk factors of CHD. Infrared spectroscopy has been introduced for monitoring chronic infections or endogenous disorders using specific absorption bands for biocomponents typed as diagnostic markers. In this study we selected specific motives of infrared radiation (IR) spectra for the sera from CHD patients infected with Hp. In total 141 sera were used: 90 from patients with CHD, all Hp positive, and 51 from healthy donors, 32 Hp negative and 21 Hp positive. Hp status was evaluated by anti-Hp IgG antibodies and/or13C urea breath testing. IR spectra were measured using FT-IR/FT-NIR Spectrum 400 spectrometer (PerkinElmer) chemometrically analyzed using artificial neural networks and they showed differences in absorption bands corresponding to triglicerides, CRP, homocysteine, LDL and TNF-α, and selected component groups between CHD patients infected with Hp vs healthy uninfected donors (96.15% accuracy). Triglicerides and CRP were the best biomarkers linking Hp infection with CHD.
Interaction between blood pressure and genetic risk score for bladder cancer, and risk of urothelial carcinoma in men
Authors: Teleka Stanley , Orho-Melander Marju , Liedberg Fredrik , Melander Olle , Jirström Karin , Stocks Tanja 
Published: October 2022

AbstractThere is substantial genetic predisposition to bladder cancer (BC). Recently, blood pressure (BP) was positively associated with BC risk in men, but the potential interaction with genetic susceptibility for BC is unknown. We investigated a weighted genetic risk score (wGRS) of 18 BC genetic variants, BP, and their interaction, in relation to incident urothelial cancer (UC, n = 385) risk in 10,576 men. We used Cox regression, the likelihood ratio test, and the relative excess risk for interaction to calculate hazard ratios (HR) of UC, multiplicative interaction and additive interaction respectively. There was evidence of a positive additive interaction between SBP and the wGRS in relation to aggressive (P = 0.02) but not non-aggressive (P = 0.60) UC. The HR of aggressive UC was for SBP ≥ 140 mmHg and the upper 50% of the wGRS combined 1.72 (95% CI 1.03–2.87) compared to the counterpart group. Additionally, the 20-year risk of aggressive UC in 60 year-old men was 0.78% in the low SBP/low wGRS group and 1.33% in the high SBP/high wGRS group. Our findings support a potential additive interaction between the wGRS and SBP on aggressive UC among men. If replicated, the findings on interaction may provide biological and public health insight to prevent aggressive UC.
Higher visual gain contributions to bilateral motor synergies and force control
Authors: Lee Tae Lee , Lee Hanall , Kang Nyeonju , Cauraugh James H. 
Published: October 2022

AbstractThis study investigated the effects of altered visual gain levels on bilateral motor synergies determined by the uncontrolled manifold (UCM) hypothesis and force control. Twelve healthy participants performed bimanual index finger abduction force control tasks at 20% of their maximal voluntary contraction across four different visual gain conditions: 8, 80, 256, and 512 pixels/N. Quantifying force accuracy and variability within a trial provided a bimanual force control outcome. The UCM analysis measured bilateral motor synergies, a proportion of good variance to bad variance across multiple trials. Correlation analyses determined whether changes in the UCM variables were related to changes in force control variables from the lowest to highest visual gain conditions, respectively. Multiple analyses indicated that the three highest visual gain conditions in comparison to the lowest visual gain increased values of bilateral motor synergies and target force accuracy. The correlation findings showed that a reduction of bad variance from the lowest to three highest visual gain conditions was related to increased force accuracy. These findings reveal that visual gain greater than 8 pixels/N facilitates bimanual force control.
Prediction of early-stage melanoma recurrence using clinical and histopathologic features
Authors: Wan Guihong , Nguyen Nga , Liu Feng , DeSimone Mia S. , Leung Bonnie W. , Rajeh Ahmad , Collier Michael R. , Choi Min Seok , Amadife Munachimso , Tang Kimberly , Zhang Shijia , Phillipps Jordan S. , Jairath Ruple , Alexander Nora A. , Hua Yining , Jiao Meng , Chen Wenxin , Ho Diane , Duey Stacey , Németh István Balázs , Marko-Varga Gyorgy , Valdés Jeovanis Gil , Liu David , Boland Genevieve M. , Gusev Alexander , Sorger Peter K. , Yu Kun-Hsing , Semenov Yevgeniy R. 
Published: October 2022

AbstractPrognostic analysis for early-stage (stage I/II) melanomas is of paramount importance for customized surveillance and treatment plans. Since immune checkpoint inhibitors have recently been approved for stage IIB and IIC melanomas, prognostic tools to identify patients at high risk of recurrence have become even more critical. This study aims to assess the effectiveness of machine-learning algorithms in predicting melanoma recurrence using clinical and histopathologic features from Electronic Health Records (EHRs). We collected 1720 early-stage melanomas: 1172 from the Mass General Brigham healthcare system (MGB) and 548 from the Dana-Farber Cancer Institute (DFCI). We extracted 36 clinicopathologic features and used them to predict the recurrence risk with supervised machine-learning algorithms. Models were evaluated internally and externally: (1) five-fold cross-validation of the MGB cohort; (2) the MGB cohort for training and the DFCI cohort for testing independently. In the internal and external validations, respectively, we achieved a recurrence classification performance of AUC: 0.845 and 0.812, and a time-to-event prediction performance of time-dependent AUC: 0.853 and 0.820. Breslow tumor thickness and mitotic rate were identified as the most predictive features. Our results suggest that machine-learning algorithms can extract predictive signals from clinicopathologic features for early-stage melanoma recurrence prediction, which will enable the identification of patients that may benefit from adjuvant immunotherapy.
Microwave spectroscopy of Andreev states in InAs nanowire-based hybrid junctions using a flip-chip layout
Authors: Zellekens Patrick , Deacon Russell S. , Perla Pujitha , Grützmacher Detlev , Lepsa Mihail Ion , Schäpers Thomas , Ishibashi Koji 
Published: October 2022

AbstractJosephson junctions based on semiconductor nanowires are potential building blocks for electrically tunable qubit structures, e.g., the gatemon or the Andreev qubit. However, an actual realization requires the thorough investigation of the intrinsic excitation spectrum. Here, we demonstrate the fabrication of low-loss superconducting microwave circuits that combine high quality factors with a well-controlled gate architecture by utilizing a flip-chip approach. This platform is then used to perform single-tone and two-tone experiments on Andreev states in in-situ grown InAs/Al core/half-shell nanowires with shadow mask defined Josephson junctions. In gate-controlled and flux-biased spectroscopic measurements we find clear signatures of single quasiparticle as well as quasiparticle pair transitions between discrete Andreev bound states mediated by photon-absorption. Our experimental findings are supported by simulations that show that the junction resides in the intermediate channel length regime.
Final closure of the Paleo Asian Ocean basin in the early Triassic
Authors: Tan Zhou , Xiao Wenjiao , Mao Qigui , Wang Hao , Sang Miao , Li Rui , Gao Limin , Guo Yuhong , Gan Jingmin , Liu Yanhong , Wan Bo 
Published: October 2022

AbstractThe timing of the final welding of the southern Altaids to construct Pangea is a matter of debate which has led to considerable uncertainty regarding the configuration of northeast Pangea and the reconstruction of proto-Asia. Here we investigate the provenance of sediments deposited within a fore-arc accretionary basin located close to the Akeyazi low temperature ultra-high pressure metamorphic complex in the South Tianshan Orogenic Belt. Detrital zircon U-Pb analysis of sandstones yields a maximum depositional age in the early Triassic (around 231.7 million years ago) with a major early Permian peak and few Precambrian records. Bulk-rock composition and zircon Hf isotopic analysis, combined with a compilation of existing data, indicate the early Triassic sediment received additional detritus from the distal juvenile East Tianshan Arc region, rather than from any proximate tectonic units or an intra-oceanic arc. Available data suggests that the South Tianshan Ocean, an accessory ocean basin to the Paleo-Asian Ocean, could close in the early Triassic.
System biology approaches identified novel biomarkers and their signaling pathways involved in renal cell carcinoma with different human diseases
Authors: Hossen Md. Saddam , Samad Abdus , Ahammad Foysal , Sasa Gabriel B.K. , Jiang Zhenggang , Ding Xianfeng 
Published: October 2022

Abstract
Renal cell carcinoma (RCC) is a type of cancer that develops in the renal epithelium of the kidney. It is responsible for approximately 3% of adult malignancies, and 90–95% of neoplasms originate from the kidney. Advances in tumor diagnosis, innovative immune therapeutics, and checkpoint inhibitors-based treatment options improved the survival rate of patients with RCC accompanied by different risk factors. RCC patients with diabetes, hepatitis C virus (HCV), or obesity (OB) may have a comorbidity, and finding the risk factor for better clinical treatment is an urgent issue. Therefore, the study focused on network-based gene expression analysis approaches to learning the impact of RCC on other comorbidities associated with the disease. The study found critical genetic factors and signal transduction pathways that share pathophysiology and commonly use dysregulated genes of the illness. Initially, the study identified 385 up-regulated genes and 338 down-regulated genes involved with RCC. OB, chronic kidney disease (CKD), type 2 diabetes (T2D), and HCV significantly shared 28, 14, 5, and 3 genes, respectively. RCC shared one down-regulated gene versican (VCAN) with OB and HCV and one down-regulated gene oxidase homolog 2 (LOXL2) with OB and CKD. Interestingly, most of the shared pathways were linked with metabolism. The study also identified six prospective biomarkers, signaling pathways, and numerous critical regulatory and associated drug candidates for the disease. We believe that the discovery will help explain these diseases’ complicated interplay and aid in developing novel therapeutic targets and drug candidates.