bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peri-operative use of ketamine infusion versus dexmedetomidine infusion for analgesia in obese patients undergoing bariatric surgery: A double-blinded three-armed randomized controlled trial
Authors: Khalil Belal , Elderh Maha , Khaja Mohamed , Ewees Bahaa , El-shaer Ahmed , Taeimah Mohamed 
Published: September 2022

Abstract
Background: The development of different techniques in bariatric surgeries has required the development of novel anesthetic techniques to reduce the incidence of complications and improve post-operative patient outcomes. Ketamine and dexmedetomidine have been used for their peri-operative analgesic profiles in different studies.
Methods: Ninety patients were studied and randomized equally into three groups. The Ketamine group received a bolus dose (0.3 mg/kg) of ketamine over 10 min followed by an infusion (0.3 mg/kg/h). The Dexmedetomidine group received a bolus dose (0.5 mcg/kg) of dexmedetomidine over 10 min followed by an infusion (0.5 mcg/kg/h). The control group received normal saline infusion. The total morphine dose was the primary outcome ,and intra-operative fentanyl requirements, time to extubation, post-operative nausea and vomiting (PONV), Numerical Rating Scale (NRS) scores, and Modified Observer’s Agitation/Sedation Scale (MOASS) scores were secondary outcomes of the study.
Results: The Dexmedetomidine group showed decreased intra-operative fentanyl requirements (160.000 ± 42.345 µcg), less time to extubation (3.700 ± 0.925 min), and better scores on MOASS than the other groups. Post-operative NRS scores and the morphine requirement in the Ketamine group (1.867 ± 2.921 mg) were lower than in the other groups. The Dexmedetomidine group showed the lowest scores for PONV.
Conclusions: The Dexmedetomidine group showed lower total fentanyl doses, a significantly shorter time to extubation, better MOASS scores, and lower PONV. The Ketamine group showed significantly lower NRS scores and morphine doses than the other two groups. Dexmedetomidine was effective on the reduction of intraoperative fentanyl requirement with early extubation, and ketamine was effective on the reduction of postoperative pain.
Trial Registration: this trail has been registered on clinicaltrials.gov registry (NCT04576975) since 06/10/2020
Outcomes of using INTRABEAM mobile intraoperative radiotherapy system to treat locally advanced pancreatic cancer: case series and literature review
Authors: Du Bingqing , Li Hang , Deng Wujian , Liang Huihong , Song Xiaodong , Yang Xuewei , Han Menling , Huang Zejun , Shao Zili , Jiang Xiaofeng 
Published: September 2022

Abstract
BACKGROUND
Intraoperative radiotherapy (IORT) has been used to control local tumor progression and release cancer pain in locally advanced pancreatic cancer (LAPC).
AIM
To evaluate the feasibility, safety,and effectiveness of the application of the INTRABEAM system for LAPC patients.
METHODS
From 2017 to 2020, all patients with LAPC underwent IORT with an INTRABEAM system and surgical resection at The Second Affiliated Hospital of Guangzhou Medical University. Patient data included perioperative management,pathologic analysis, postoperative adjuvant therapy, and follow-up.
RESULTS
A total of 10 LAPC patients who underwent IORT were identified from 2017 to 2020. All patients had no metastasis but had a vascular invasion.Among them, 9 patients (9/ 10,90.0%) had artery invaded, and 1( 1/ 10, 10.0%) patient had vein invaded.Among 10 patients who underwent surgery, 2 (2/ 10,20.0%) faced Grade B pancreatic fistula (CD II) and 3(3/ 10,30.0%) faced surgical incision infection (CD I).Severe complications (CD III-IV) and death up to 30 days were not found. Only 2 (2/ 10,20%) patients accepted postoperative adjuvant therapy; one received chemotherapy due to local recurrence, and the other received radiofrequency ablation due to liver metastasis. The median follow-up time was 16.0 months (range, 5.0–20.0 months).Kaplan–Meier analysis indicated that the 1-year survival and cumulative PFS rates were70% and 40%.The median survival time was 15 months(95% CI: 10.3– 19.6months).
CONCLUSION
INTRABEAM system was safe, personalized, and effective for treating patients with LAPC in IORT.
Determinants of the number of children born in Ethiopia, evidenced from 2019 miniEDHS: Using zero-truncated count regression models
Authors: Worku Getahun , Tadesse Getachew , Arega Amsalu , Tesfaw Dejen 
Published: September 2022

Abstract
Background

In many countries, deferring first births and increasing the interval between births has played an important role in lowering fertility rates. Any country's fertility rate is a key demographic indicator, and it has always been important to closely monitor changes in the pattern of births to determine how many children are being conceived. Any country's fertility rate is a key demographic indicator, and it has always been important to closely monitor changes in the pattern of births to determine how many children are being conceived. The primary goal of this study is to apply zero-truncated regression models to estimate the number of children ever born per mother in Ethiopia from the MiniDHS 2019.

Mothods

The data collection was carried out by the Ethiopian Public Health Institute (EPHI) in collaboration with the Central Statistical Agency (CSA) and the Federal Ministry of Health. Zero truncated count regression models were used to identify the determinant of the number of children ever born from Ethiopian mothers.

Results

The response variable (children ever born) has a range of 1–15. There were 5,753 observations in this study, with the mean and standard deviation of the response variable being 4.04 and 2.48, respectively. According to AIC and BIC model selection criteria and over-dispersed parameter in zero-truncated negative binomial assured the appropriateness of zero-truncated Poisson regression model for this dataset.

Conclusion

The number of children ever born increases with the age group of mothers, but it decreases as mothers' education levels rise. Similarly, region, religion, wealth index, residence area, number of living children, the number of births in the last five years, age at first birth all had a significant impact on the number of children ever born.
Characteristics of Category Natural Deduction for Language Propositional Logic System (CCND) for (LPLS)
Authors: Al-Odhari Adel Mohammed 
Published: September 2022

Abstract

In this paper, we introduce the third system which is called category of natural deduction (CND) for propositional logic system (LPLS), it's essential different in its form and ways form truth -table and truth-tree for (LPLS), even its pick out (or select) the same symbolic language like that used in system of truth-table and truth- tree for (LPLS). Anyway, with regarding to truth -table and truth-tree for (LPLS) ,there is a terminology which is called algorithm due to mathematician Muhammed ibn Musa al-khwarizmi (780–850), from meaning of algorithm, that is there are some mechanical procedures, that we commit to it leading us to right judgment relative to arguments. In this paper we make a new presentation method for (CND) for (LPLS)), the principle of system of natural deduction is based on Garhard Gentzen, how investigated and published his work in 1934 and 1935 about it. In this article, we represent natural deduction as a category natural deduction for language propositional logic system and study characteristics of arguments in (CND) and investigates valid and invalid arguments, types of formulas and relations between formulas and inconsistence sets.
Social media use among the least influential factors in adolescent mental health: Results from a panel network analysis
Authors: Panayiotou Margarita , Black Louise , Carmichael-Murphy Parise , Qualter Pamela , Humphrey Neil 
Published: September 2022

Abstract
There is growing concern about the role of social media use in the documented increase of adolescent mental health difficulties. However, the current evidence remains complex and inconclusive. While increasing research on this area of work has allowed for significant progress, the impact of social media use within the complex systems of adolescent mental health and development is yet to be examined. The current study addresses this conceptual and methodological oversight by applying a panel network analysis to explore the role of social media on the interacting systems of mental health, wellbeing, and social life of 12,041 UK adolescents. We find that across time, social media is one of the least influential factors of adolescent mental health with other factors (e.g. bullying, lack of family support) deserving greater attention. Our findings suggest that the current depiction of social media use as the culprit of adolescent mental health difficulties is unwarranted and highlight the need for social policy initiatives that focus on the home and school environment to foster resilience.
Natural regeneration of drylands and associated pathways to human health outcomes: perspectives from rural households
Authors: Murage Peninah , Asenga Ayoub , Tarimo Angelina , Njung'e Tabby , Zaan Thijs van der , Chiwanga Faraja 
Published: September 2022

Abstract
Land degradation and climate change are intertwined global challenges, their implications on human health is driven by unsustainable use of natural resources which results to loss of vital ecosystem services. Although exploitation of natural resources has benefited human-wellbeing, it has also resulted to catastrophic degradation of landscapes, acutely affecting populations living in the most fragile ecosystems. Landscape restoration is widely advocated to reverse degradation, however, implementation has outpaced research on impact, particularly with regards to human-health outcomes. This study documents perspectives of rural communities living in dryland and demonstrates a novel application of ecosystem services framework to conceptualise the pathways to health. The analysis of group discussions show how Farmer Managed Natural Regeneration (FMNR) can reverse decades of land degradation with cascading benefits on climate change resilience and multiple health outcomes linked to heat adaptation, sustained food and nutritional security, improved air and water quality, income diversification and gender equality.
Spatial and temporal variations in b-value of earthquake magnitude–frequency distributions and crustal stress in north part of the Zagros region
Authors: Mousavian Samira , Mostafazadeh mehrdad 
Published: September 2022

Abstract

In this paper, high-resolution map of the Gutenberg–Richter b-value and differential stress field and stress drop are provided for the north part of the Zagros region. This region is important because more than 10 earthquakes with magnitude greater than 6 occurred in this region in the past. In order to understand tectonic stress pattern of the region, the catalogue of seismicity between 1900 and 2020 was used (most of the events that could be used in this region) in order to explore the spatial and temporal variations of the b-value, which corresponds to the slope of the frequency-magnitude distribution of the earthquakes. We estimate the differential crustal stress from the b-value using a relationship published by Scholz (GeophytsRes Lett 42:1399–1402, 2015) and focused on estimating b-value first in the whole north of Zagros belt and then in 3 sub regions. For entire north of Zagros and sub regions, the average content of Mc is 4.0 (Based on Kijko-Sellevoll (Bull Seism Soc Am 79(3):645–654, 1989)) and content of b-value in this regions is around 1.03 to 1.12 and the b-value is gradually have lower value, from west to the East of Zagros. In all earlier studies, b-value was estimated for the entire of the Zagros but in this study, we estimated the b-value based on tectonic units of the region. In temporal variation of b-value, one minimum in the diagram of b-value in MFF region can be seen exactly before 12 Nov. 2017Ezgeleh earthquake (Mw=7.3) and another minimum in diagram is related to the 18 August 2014 Mormori earthquake (Mw=6.2). The stress drop was estimated from M0for north part of the Zagros and compared this value in time period before and after Ezgele earthquake. The stress drop value before and after Ezgeleh earthquake, around the epicenter was changed between 0.024–0.03 before earthquake to 0.13–0.261 MPa after the earthquake respectively. Finally we are calculated the differential stress value in time period before and after Ezgele Earthquake, around the epicenter, and it is changed between 300–322 MPa before earthquake to 238–295 MPa after the earthquake respectively. Also it seems that stress transmitted from north part of the Zagros to the central part of it.
A novel in silico Nuss procedure for pectus excavatum patients
Authors: Lim Beop-Yong , Ryu Dongman , I Hoseok , Lee Chiseung 
Published: September 2022

Abstract
The purpose of this study is to suggest a novel in silico Nuss procedure that can predict the results of chest wall deformity correction. 3D geometric and finite element model of the chest wall were built from the 15-year-old male adolescent patient’s CT image with pectus excavatum of the mild deformity. A simulation of anterior translating the metal bar (T) and a simulation of maintaining equilibrium after 180-degree rotation (RE) were performed respectively. A RE simulation using the chest wall finite element model with intercostal muscles (REM) was also performed. Finally, the quantitative results of each in silico Nuss procedure were compared with those of postoperative patient. Furthermore, various mechanical indicators were compared between simulations. This confirmed that the REM simulation results were most similar to the actual patient's results. Through two clinical indicators that can be compared with postoperative patient and mechanical indicators, the authors consider that the REM of silico Nuss procedure proposed in this study is best simulated the actual surgery.
Associations of Bone Mineral Density, Trabecular Bone Score and Hepatic/Pancreatic Iron Overload Evaluated by Quantitative T2* MRI
Authors: Zhang Zaizhu , Hou Bo , Du Guiying , Sun Pengtao , Guan Wenmin , Lin Qiang , Han Bing , Yu Wei 
Published: September 2022

Abstract
Background
Iron-overloaded patients are recognized as presenting an increased risk of osteoporosis. However, studies on the correlation between osteoporosis and organ iron overload are controversial or scarce. The aim of this study is to assess bone mineral density (BMD) and trabecular bone score (TBS) in correlation with hepatic and pancreatic iron overload.
Methods
Forty-one patients diagnosed with hemoglobinopathies, were studied. BMDs of the lumbar spine (LS), femoral neck (FN), and total hip (TH) were analyzed by Dual-energy X-ray absorptiometry (DXA) scan. LS bone quality was derived from each spine DXA examination using the TBS analysis. Hepatic and pancreatic iron overload were obtained with a multi-echo gradient echo T2* technique.
Results
Abnormal microarchitecture and abnormal bone mass were observed in 19/41 (46.3%) and 9/41 (22.0%) patients, respectively. For 26 males, BMD, T-score and Z-score of LS were significantly lower among subjects with moderate-severe hepatic iron-overload than their counterparts, as it is between no- and pancreatic iron-overload groups. For 15 females, patients with moderate-severe hepatic iron-overload had significantly lower BMD and T-score of FN and TH, and patients with pancreatic iron-overload had significantly lower BMD, T-score of FN, and lower BMD, T-score and Z-score of TH than their counterparts. Moreover, pancreatic T2*-value was positively correlated with BMD and T-score at all analyzed sites and Z-score at TH.
Conclusion
These data showed lower bone mass in patients with organ iron overload, particularly for LS in males, FN and TH in females. TBS may well represent a complementary tool for the evaluation of bone quality and the risk of fracture in iron-overloaded patients.
An intercultural analysis of the websites and tourist destinations profiles on social networks, from the perspective of digital accessibility and inclusive communication. Case study for Andalusia and Northern Morocco.
Authors: Montero Alexander Aguirre , Sales Lola Hernández Sales Hernández , Idrissi Mohammed Youbi , Sánchez José Antonio López 
Published: September 2022

Abstract
Tourists with disabilities, representing approximately 15% of the world's population, especially need everything planned for their tourist experiences. Therefore, the contents and level of digital accessibility are vital and significantly impact the final decision to travel to one destination. This work aims to analyse the digital accessibility content developed by destinations in Andalusia and Northern Morocco from the perspective of web accessibility and inclusive communication in social media. The method used is multidisciplinary, carrying out a series of analyses through the statistical language R, TAW as an online tool to analyse the website's accessibility and synthesise guidelines for communicating inclusively in social networks. The main results show the scarce involvement of public bodies to communicate inclusively designing content from the universal design perspective. There is no substantial difference between the two regions studied, by identifying that European legislation and national regulatory framework in Andalusia's case do not favour a better level of web accessibility, although this is a mandatory aspect. Furthermore, we have found very few differences in analysing the performance level of destinations under the umbrella of Smart Tourism Destinations when accessibility is fundamental in their conceptualisation. Finally, this research can be identified as state-of-the-art in tourism marketing as a conceptual approach and a starting point for measuring inclusive communication in social networks. Nowadays, accessible tourism is an opportunity to be placed at the centre of recovery plans in the post-Covid 19 eras. Therefore, let us facilitate more inclusive societies, using tourism as a lever to achieve this goal.
Transposable elements derived microRNA expression patterns in TCGA dataset and evolutionary analysis for 10 species
Authors: Lee Chan-Mi , Jin Sang Woo , Jang Byunghyun , Ko Young Kyung , Gim Jeong-An 
Published: September 2022

Abstract
Background
miRNA acts as a disease regulator. An evolutionary approach to disease could discover factors such as diagnosis, treatment, and prognosis prediction. Therefore, the expression level and expression pattern of each cancer type of transposable elements (TEs)-related disease-related miRNAs were identified, and their evolutionary patterns were identified.
Methods
The 34 miRNAs were compared by stage survival, and tumor status in 33 carcinomas of TCGA. The expression levels were compared by t-test, and presented as differentially expressed miRNAs (DEMs). For DEMs showing statistically specific expression patterns for a total of three conditions (normal and cancer, early and advanced stage, and survival), interactions with related genes in a total of 10 species including humans were compared. The enrichment term was discovered for the gene-miRNA interaction.
Results
In 18 of the 33 carcinomas, at least one miRNA was retrieved by p < 0.05 and |fold change| > 0.05 conditions. A total of 128 DEMs for 9 miRNAs were presented. Based on the TargetScan database, interactions between miRNAs and genes in a total of 10 species including the human were confirmed. The evolutionarily best conserved miR-130a was observed in all 10 species, whereas miR-151a was observed only in the human. GO terms of related genes were selected for miRNAs commonly found in each species.
Conclusions
Evolutionary analysis of TE-derived disease-associated miRNAs was performed, and the evolutionarily conserved miR-130a-related carcinomas were renal and thyroid cancers. Human and rhesus monkey-specific miR-625 was associated with a variety of carcinomas.
Efficacy of three sputum specimens for the diagnosis of Mycobacterium avium complex pulmonary disease
Authors: Urabe Naohisa , Sakamoto Susumu , Masuoka Marie , Kato Chiaki , Yamaguchi Asuka , Tokita Nozomi , Homma Sakae , Kishi Kazuma 
Published: September 2022

Abstract
Background: In Mycobacterium avium complex pulmonary disease (MAC-PD), diagnosis requires a positive culture from at least two separate expectorated sputum specimens. The optimal number of sputum examinations remains unclear.
Objective: This study sought to elucidate the diagnostic yield of acid-fast bacilli in MAC-PD using 3 sputum specimens and to clarify the clinical characteristics of patients with MAC-PD diagnosed using 3 sputum specimens. Furthermore, we investigated the correlation between increased number of sputum specimens and diagnostic yield.
Methods: We reviewed the medical records of 153 patients with MAC-PD diagnosed at Toho University Omori Medical Center for whom at least three sputum specimens were examined before treatment from November 2014 through June 2021. Patients were classified into the 3-sputum diagnosed and the non-3 sputum diagnosed groups based on diagnostic procedure; clinical and radiological characteristics were compared. We also assessed diagnostic yield with the increased number of sputum specimens.
Results: Diagnostic yield with 3 sputum specimens was 19% (29/153). The 3-sputum diagnosed group had a lower body mass index (18.0±2.3 vs. 19.7±3.0 kg/m2; p=0.002) and higher chest CT score (10.7±4.9 vs. 7.2±4.0; p=0.001) including cavitary lesions (51.7% vs 20.2%; p=0.002) compared with the non-3 sputum diagnosed group. When the number of sputum specimens was increased to 6, the diagnostic yield increased to 26.1% (40/153).
Conclusion: Diagnostic yield with 3 sputum specimens was 19%. Patients diagnosed using 3 sputum specimens had more severe chest CT findings including cavitary lesions. Increasing the number of sputum specimens to 6 improved diagnostic yield by 7.1%.
Surgical Bleeding in Patients Undergoing Posterior Lumbar Inter body Fusion Surgery: A Randomized Clinical Trial Evaluating the Effect of Two Mechanical Ventilation Mode Types
Authors: Hajijafari Mohammad , Ziloochi Mohammad Hossein , Salimian Manoochehr , Fakharian Esmaeil 
Published: September 2022

Abstract

Background The purpose of the study was to compare the effect of using Volume-Controlled Ventilation (VCV) versus Pressure-Controlled Ventilation (PCV) on blood loss in patients undergoing Posterior Lumbar Inter body Fusion (PLIF) surgery. Methods In a randomized, single-blinded, parallel design, 78 patients candidate for PLIF surgery were randomly allocated into two groups of 39 to mechanically ventilated using VCV or PCV mode. All the patients were operated in prone position by one surgeon. Amount of intraoperative surgical bleeding, transfusion requirement, surgeon satisfaction, hemodynamic parameters, heart rate, and blood pressure were measured as outcomes. Results PCV group showed slightly better outcomes than VCV group in terms of mean blood loss (431 cc vs. 465 cc), transfusion requirement (0.40 vs. 0.43 unit), and surgeon satisfaction (82.1% vs. 74.4%); however, the differences were not statistically significant. Diastolic blood pressure 90 and 105 min. after induction were significantly lower in PCV group (P = 0.043 & 0.019 respectively); however, blood pressure in other times, hemoglobin levels, and mean heart rate were similar in two groups. Conclusions In patients undergoing Posterior Lumbar Inter body Fusion surgery, mode of ventilation cannot make significant difference in terms of blood loss; however, some minor benefits in outcomes may lead to the selection of PCV rather than VCV. More studies with larger sample size, and investigating more factors may be needed.