bluuebunny/crossref_metadata_2025_split huggingface dataset:
27-Hydroxycholesterol induces expression of zonula occludens-1 in monocytic cells via multiple kinases pathways
Authors: Cho Hyok-rae , Kim Bo-Young , Kim Koanhoi , Lee Dongjun , Eo Seong-Kug , Son Yonghae 
Published: May 2022

AbstractZonula occludens (ZO)-1, a tight-junction protein (TJP), is expressed in dendritic cells (DCs) but not in monocytes, and 27-hydroxycholesterol (27OHChol) drives the differentiation of monocytes into DCs. Because the effects of 27OHChol on ZO-1 are not yet clearly defined, we investigated whether 27OHChol induces expression of the TJP. The treatment of human THP-1 monocytic cells with 27OHChol resulted in the elevated transcript levels of ZO-1 but not of ZO-2 or -3. 27OHChol increased the total amount of ZO-1 protein in the cells as well as its level on the cells surface. Cholesterol, however, did not influence expression of ZO-1. And, the expression of ZO-1 protein was mediated by endoplasmic reticulum (ER)-to-Golgi body transport system. Pharmacological kinase inhibition with LY294002 (a PI3K inhibitor), U0126 (a MEK/ERK inhibitor), or PP2 (a Src family kinase inhibitor) resulted in impaired ZO-1 expression at both transcript and protein levels. Drugs that are reported to suppress DC differentiation also inhibited 27OHChol-mediated expression and the localization of ZO-1, indicating the coincidence of ZO-1 upregulation and DC differentiation. These results suggest that ZO-1 is differentially expressed while monocytes differentiate into DCs in the presence of 27OHChol via pathways in which distinct signaling molecules are involved.
Effect of the pressureless post-sintering on the hot isostatic pressed Al2O3 prepared from the oxidized AlN powder
Authors: Balázsi K. , Varanasi D. , Horváth Zs. E. , Furkó M. , Cinar F. S. , Balázsi C. 
Published: May 2022

AbstractThe effect of the pressureless post-sintering in hydrogen on the structural and mechanical properties of the hot isostatic pressed Al2O3 prepared by oxidized AlN powder has been studied. The micrometer size AlN powder has been oxidized in air at 900° C and sintered by hot isostatic pressing (HIP) at 1700 °C, 20 MPa nitrogen atmosphere for 5 h. Pressureless sintering (PS) has been applied for all HIP sintered samples in H2 gas at 1800° C for 10 h. It has been shown that the oxidation caused a core–shell AlN/Al2O3 structure and the amount of Al2O3 increased with increasing of the oxidation time of the AlN powder. For the first time, the green samples obtained from oxidized AlN powder have been successfully sintered first by HIP followed by post-sintering by PS under hydrogen without adding any sintering additives. All post-sintered samples exhibited the main α-Al2O3 phase. Sintering in H2 caused the full transformation of AlN to α-Al2O3 phase and their better densification. Therefore, the hardness values of post-sintered samples have been increased to 17–18 GPa having apparent densities between 3.11 and 3.39 g/cm3.
Amplifying subtropical hydrological transition over China in early summer tied to weakened mid-latitude synoptic disturbances
Authors: Li Yana , Deng Yi , Cheung Ho-Nam , Zhou Wen , Yang Song , Zhang Henian 
Published: May 2022

AbstractThe rainy season over southern China (SC) begins with the onset of the South China Sea monsoon around mid-May. We demonstrate here that the SC precipitation exhibits a notable drying (wetting) trend prior to (after) the monsoon onset, leading to a more abrupt thus amplified hydrological transition over SC in early summer. The contrasting precipitation trends are largely driven by the recent decline in mid-latitude synoptic eddy activity. Weakened mid-latitude synoptic disturbances suppress SC frontal activities before the monsoon onset, facilitating the drying trend, and enhance the spatial stationarity of the SC monsoonal front after the monsoon onset, leading to the wetting trend. CMIP6 models in general fail to capture the contrasting trends between the two periods. In models where both the trends in precipitation and mid-latitude synoptic eddy activity are well captured, the amplification of the hydrological transition over SC is projected to continue well into the late 21st century. Our results highlight the footprints of hemispheric-scale climate change in regional hydroclimate and the obvious challenges faced by climate models in capturing such footprints.
Clinical Focus: Findings and Clinical Implications for Thickening Formula With Infant Cereal Using the International Dysphagia Diet Standardisation Initiative Flow Test
Authors: Stevens Melanie , O'Rourke Sara , Casto Shelley Coleman , Benedict Jason , Lundine Jennifer P. 
Published: May 2022

Purpose:
The International Dysphagia Diet Standardisation Initiative (IDDSI) framework was established to provide standardized terminology and objective measures to assess foods and liquids for persons with swallowing difficulties. This clinical focus article reports the findings and clinical implications of the flow testing of infant formulas thickened with infant cereal completed as part of the transition process to IDDSI for one large pediatric quaternary care hospital.

Method:
To determine a common recipe that could be used to thicken formulas with infant cereal to the appropriate IDDSI levels, three clinicians completed flow testing on 94 infant formulas. To examine intra- and interclinician variability in the process, they repeated flow testing with three commonly used formulas and infant cereal.

Results:
Clinicians were unable to identify a standard recipe (infant formula + infant cereal combination) that consistently thickened different formula brands to a desired IDDSI thickness level, as there was pronounced variability across and within infant formulas. Reliability testing revealed that, overall, clinician mixers were consistent in replicating similar results to themselves and to each other and that, instead, greater variability lies within the formula (and infant formula + infant cereal combination).

Conclusions:
Based on findings of pronounced variability within and across infant formulas, our institution determined that the creation of a standard recipe for achieving IDDSI thickness levels of formula mixed with infant cereal was not feasible or clinically appropriate. We offer recommendations for similar institutions for advancing clinical management of infant dysphagia using the IDDSI flow test and directions for future research.
School-Level Predictors of Speech-Language Therapy Enrollment
Authors: Shanks Lauryn , Hall-Mills Shannon 
Published: May 2022

Purpose:
There are extensive concerns about the size of speech-language caseloads in schools. However, little empirical data exist regarding the patterns of speech-language services enrollment. We reviewed data from several hundred schools in a large state to explore the role of school-level factors in speech-language case enrollment.

Method:

Child count and enrollment data reports from a stratified sample of schools located within 12 Florida school districts (
N
= 808) were drawn from the Florida Department of Education portal for the 2018–2019 school year. Three school districts were selected from each of several population sizes. To control for school population size, the raw numbers for each variable were converted into proportions. To examine the relations among variables, multiple correlational and regression analyses were conducted.

Results:
The results indicated that two school-level factors significantly predicted the total speech-language services enrollment and language therapy enrollment (e.g., proportion of students of low socioeconomic status [SES], passing the state reading assessment), whereas three school factors significantly predicted the speech therapy enrollment (e.g., proportion of low-SES students, passing the reading assessment, and enrolled in English as a second or other language services).

Conclusions:
The outcomes of this study suggested that school factors can predict speech-language service enrollment, which offers important implications for decision makers in schools. Implications for educational practices and further research are presented.
Effect of contamination and relative humidity on the function of thyristor voltage monitoring board
Authors: Liu Zichen , Wang Liming , Mei Hongwei , Cao Bin , Yin Fanghui , Xu Yongsheng , Zhang Fuzeng , Jiang Yi , Farzaneh Masoud 
Published: May 2022

AbstractIn recent years, shutdown accidents caused by thyristor voltage monitoring (TVM) board failure have occurred several times in converter stations. With the increase of operation time, the working reliability problem of TVM board becomes a challenge to the safe operation. This paper studies the effects of pollution severity and relative humidity (RH) on the function of TVM board. The results show that the increase of RH can lead to the advance or even disappearance of check‐back signals. Furthermore, the increase of pollution severity can decrease the failure RH threshold. Through simulation and equivalent experiment, it is verified that the resistance decrease of the voltage balancing resistor under the combined effect of contamination and RH is the main reason for the advance of check‐back signals. According to the experiments, it is found that the upper surface contamination has a greater effect on the function of TVM board than the lower surface contamination, resulting in more decrease of the failure RH threshold. In addition, leakage current at different RH is also measured. Results show that the pulse peak of leakage current is closely related to check‐back signals. When the pulse peak is too small or disappears, check‐back signals also disappear, indicating that the TVM board fails.
Bit‐level image encryption algorithm based on fully‐connected‐like network and random modification of edge pixels
Authors: Sheng Yaohui , Li Jinqing , Di Xiaoqiang , Man Zhenlong , Liu Zefei 
Published: May 2022

AbstractA bit‐level image encryption algorithm based on Fully‐Connected‐Like network(FCLN) and random modification of edge pixels is proposed. In the paper, in order to enhance the security of the cryptographic system, random noise is first used to modify the least significant bits of the edge pixels of the image, and the modified image is used as the input image. Later,the chaotic sequence is used to perform cyclic shift transformation on the image. In the subsequent steps, the FCLN is generated based on a fully connected neural network, which can perform scrambling and diffusion operations on the input image. Finally, the bidirectional diffusion method is used to diffuse the image forward and backward. In addition, the image after the edge pixel modification is convolved with the chaotic sequence, and the initial value of the chaotic system is set by the result to establish the correlation between the plain image and the algorithm, which makes the algorithm resistant to known/chosen plaintext attack. Experimental results show that although the image is modified by random noise, the decrypted image is visually the same as the original image. At the same time, through the analysis of common attacks such as differential attacks, noise attacks, and data loss attacks, our algorithm shows high security.
A reflective metasurface for generating dual‐mode dual‐polarized high‐order Bessel vortex beams with equal divergence angle
Authors: Huang Yuhan , Li Xiuping , Guo Xiaobin , Qi Zihang , Zhu Hua , Li Qingwen 
Published: May 2022

AbstractA single‐layer reflective metasurface is proposed in this study to generate dual‐mode dual‐polarized high‐order Bessel vortex beams with equal divergence angle in Ka‐band. The metasurface consists of two different subwavelength elements with different polarisations, which are located in the inner disk region and the outer ring region respectively. The inner element, composed of a square ring and a regular octagon, is proposed to achieve a phase response of 360°. The outer element, which consists of a microstrip line and a double W‐shaped line, is designed to achieve the phase compensation and polarization conversion simultaneously. Equal divergence angle of different orbital angular momentum (OAM) modes is achieved by theoretically calculating the radii of the inner and outer regions. The metasurface prototype is fabricated and tested at 29 GHz, and the results show that the high‐order Bessel beams with +1 mode of x‐polarization and +2 mode of y‐polarization are successfully generated. This work provides a simple and practical method to generate dual‐mode dual‐polarized high‐order Bessel vortex beams for high‐capacity OAM communications.
Implantatversagen HWS-LWS nach langstreckigen Instrumentierungen beim
Knochengesunden – Ursachen und Behandlungskonzepte
Authors: Bullmann Viola 
Published: May 2022

ZusammenfassungEin Implantatversagen bei langstreckigen Instrumentation droht insbesondere bei nicht
Erreichen einer regelrechten Balance. Hierbei treten insbesondere Anschlusskyphosierung
mit Anschlussfrakturen oder Schrauben-cut-outs auf. Bei der operativen Revision sollten
die lumbopelvinen Parameter ermittelt und entschieden werden, ob eine Osteotomie
zusätzlich zur Verlängerung der Instrumentationsstrecke erforderlich ist.Im lumbosakralen Übergang besteht ein erhöhtes Pseudarthroserisiko bei postoperativ
persistierender sagittaler Dysbalance oder mangelhafter lumbosakraler Fixierung. Bei der
Revision einer Pseudarthrose muss diese vollständig reseziert und stabil und mit einem
pressfiten mit Knochen oder BMP befüllten Implantat abgestützt werden. Dorsal sollte die
Instrumentierung bis aufs Ilium verlängert werden.
Stammzelltherapie bei Typ-1-Diabetes
Authors: Ludwig Barbara 
Published: May 2022

ZUSAMMENFASSUNGEs sind spannende Zeiten für Diabetesforscher, klinische Diabetologen und Patienten mit Diabetes. Hundert Jahre nach der Entdeckung des Insulins haben zwei Forschergruppen die ersten Ergebnisse von Studien zur Transplantation von Patienten mit Diabetes mellitus Typ 1 mit Stammzell-basierten Inselzellen vorgestellt. Dies stellt zweifelsfrei einen Meilenstein insbesondere für Patienten mit Diabetes mellitus Typ 1 dar. Bei dieser Form des Diabetes kommt es zu einer autoimmun-vermittelten Zerstörung der Insulin-produzierenden Betazellen des Pankreas. Die Folgen sind eine komplette endogene Insulindefizienz und die Notwendigkeit zur lebenslangen Substitution von Insulin. Die aktuelle Forschung untersucht nun den Einsatz von Stammzellen zur Herstellung von Betazellen und erste klinische Studien laufen. Im Folgenden soll der aktuelle Stand der biologischen Betazell-Ersatztherapie, die Perspektiven, aber auch die bestehenden Limitationen und offenen Fragen dieser Forschungsrichtung beleuchtet werden.
Contemporary Management of Microtia
Authors: Abrol Anish , Bly Randall , Sie Kathleen C. Y. , Bhrany Amit D. 
Published: May 2022

AbstractMicrotia techniques have evolved to improve esthetic outcomes, reduce donor site morbidities, and reduce complications. Patients with microtia commonly have aural atresia associated with conductive hearing loss. We present the evolution of our technique for microtia reconstruction and considerations for hearing management in these patients.
Displaying Cost and Completion Time for Reference Laboratory Test Orders—A Randomized Controlled Trial
Authors: Ikoma Shohei , Pierce Logan , Bell Douglas S. , Cheng Eric M. , Drake Thomas , Guo Rong , Ziman Alyssa 
Published: May 2022

Abstract
Objectives Reduction in unnecessary services is one strategy for increasing the value of health care. Reference laboratory, or send-out, tests are associated with considerable costs. We investigated whether displaying cost and turnaround time (TAT), or time-to-result, for reference laboratory tests at the time of order entry in the electronic health record (EHR) system would impact provider ordering practices.
Methods Reference laboratory test cost and TAT data were randomized prior to the study and only displayed for the intervention group. A 24-month dataset composed of 12 months each for baseline and study periods was extracted from the clinical data mart. A difference-in-differences (DID) analysis was conducted using a linear mixed-effects model to estimate the association between the intervention and changes in test-ordering patterns.
Results In the inpatient setting, the DIDs of aggregate test-order costs and volume were not different among the control and intervention groups (p = 0.31 and p = 0.26, respectively). In the ambulatory setting, the DIDs of aggregate test-order costs and volume were not different among the control and intervention groups (p = 0.82 and p = 0.51, respectively). For both inpatient and ambulatory settings, no significant difference was observed in the DID of aggregate test-order costs and volumes calculated in respect to stratified relative cost and TAT groups (p > 0.05).
Conclusion Lack of alternative tests, test orders placed at a late step in patient management, and orders facilitated by trainees or mid-level providers may have limited the efficacy of the intervention. Our randomized study demonstrated no significant association between the display of cost or TAT display and ordering frequency.
Polarized Microscopic Analysis of Picrosirius Red Stained Salivary Gland Pathologies: An Observational Study
Authors: Juengsomjit Rachai , Meesakul Ounruean , Arayapisit Tawepong , Larbcharoensub Noppadol , Janebodin Kajohnkiart 
Published: May 2022

Abstract
Objective Salivary gland diseases and their pathologies may affect the glandular structure including collagen, a major stromal component, in response to tissue damage or diseases. This study aimed to examine the changes in collagens in different salivary gland diseases using polarized picrosirius red staining.
Materials and Methods The submandibular gland samples diagnosed as sialadenitis, chronic sclerosing sialadenitis, pleomorphic adenoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma were stained with picrosirius red, Masson's trichrome, and anticollagen I staining. The quantity of collagens was examined and reported as a percentage of positive picrosirius red area. The maturity of collagens was studied with polarized light microscope and reported as a percentage of orange-red and yellow-green polarized collagens, representing the mature and immature collagens, respectively.
Statistical Analysis The % positive areas for picrosirius red representing the collagen amount among salivary gland diseases were analyzed by one-way analysis of variance with Tukey's test. The % orange-red and % yellow-green polarized areas representing the collagen maturity were analyzed by Kruskal–Wallis test and Mann–Whitney U test.
Results The malignant tumors, adenoid cystic carcinoma (29.92) and mucoepidermoid carcinoma (26.59), had higher significant percentage of positive picrosirius red area, compared with the benign tumor (14.56), chronic sclerosing sialadenitis (10.61), and sialadenitis (7.22) (p < 0.05). The percentages of orange-red polarized areas are 48.07, 39.6, 62.67, 83.75, and 76.05 in sialadenitis, chronic sclerosing sialadenitis, pleomorphic adenoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma, respectively. This percentage tended to increase in the benign and malignant lesions with statistical difference, compared with the inflammatory lesions (p < 0.05). There was no statistical difference in the percentages of yellow-green polarized areas among various salivary gland diseases. In addition, the results of Masson's trichrome and anticollagen I staining are corresponding to that of picrosirius red among various salivary gland diseases.
Conclusions Polarized picrosirius red demonstrated the most amounts of collagen in the malignant lesion, and represented the different maturity of collagens in each lesion group. Studying the amounts and maturity of collagen with picrosirius red for extracellular matrix alteration in salivary gland diseases along with routine hematoxylin and eosin, Masson's trichrome, and immunohistochemistry may provide a better understanding in different salivary gland pathologies.
Simulation-Facilitated Education for Pediatric Critical Care Nurse Practitioners' Airway Management Skills: A 10-Year Experience
Authors: Thompson Allison , Irving Sharon Y. , Hales Roberta , Quinn Ryan , Chittams Jesse , Himebauch Adam , Nishisaki Akira 
Published: May 2022

AbstractThis study aimed to describe the process of the development and implementation with report of our 10-year experience with a simulation-facilitated airway management curriculum for pediatric acute care nurse practitioners in a large academic pediatric intensive care unit. This is a retrospective observational study. The study was conducted at a single-center quaternary noncardiac pediatric intensive care unit in an urban children's hospital in the United States. A pediatric critical care airway management curriculum for nurse practitioners consisting 4 hours of combined didactic and simulation-facilitated education followed by hands-on experience in the operating room. Tracheal intubations performed by nurse practitioners in the pediatric intensive care unit were tracked by a local quality improvement database, NEAR4KIDS from January 2009 to December 2018. Since curriculum initiation, 39 nurse practitioners completed the program. Nurse practitioners functioned as the first provider to attempt intubation in 473 of 3,128 intubations (15%). Also, 309 of 473 (65%) were successful at first attempt. Implementation of a simulation-facilitated pediatric airway management curriculum successfully supported the ongoing airway management participation and first attempt intubation success by nurse practitioners in the pediatric intensive care unit over the 10-year period.
Ex Vivo Evaluation of the Cranial Tibial Artery and Its Compression through Fragment Rotation during Tibia Plateau Levelling Osteotomy: An Angiographic Three-Dimensional Reconstruction
Authors: Cieciora Lena-Charlott , Harms Oliver , Freise Fritjof , Seifert Hermann , Fehr Michael 
Published: May 2022

AbstractObjective To illustrate the arterial vascularity of the proximal tibia three-dimensionally and to evaluate the impact of fragment rotation on the cranial tibial artery by tibia plateau levelling osteotomy (TPLO).Methods Radiographic angiography and computed tomography (CT) were performed on 12 pelvic limbs from six large-breed canine cadavers before and after TPLO. Three-dimensional (3D) models of the stifle, including osseous and vascular structures, were obtained, and the integrity of the cranial tibial artery was assessed. Post-TPLO CT images were used to analyze compression of the cranial tibial artery by the rotated fragment.Results The uncompressed cranial tibial artery caliber, measured proximally and distally to the osteotomy, was 9.52 mm2 (6.07–18.90 mm2). In all adequately rotated fragments, the mean caliber of the artery on the level of the osteotomy was 1.57 mm2 (0.89–2.93 mm2) after TPLO. This represented a significant decrease of approximately 81%. Only slight cross-sectional area decrease (8.8%) was seen in one limb, which was revealed to have insufficient fragment rotation (2.83 mm). Another limb only showed signs of stretching of the artery (31.51%), which was under-rotated and medially displaced. Pre-TPLO 3D reconstructions were mainly consistent with previous anatomic studies except for the distance between tibial cortex and cranial tibial artery, which appeared closer.Conclusion Sufficient fragment rotation leads to compression of the cranial tibial artery. Intraoperative hemorrhage can be caused by laceration of the main cranial tibial artery or by multiple small branches reaching craniolaterally.