bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visualization of non-Newtonian convective fluid flow with internal heat transfer across a rotating stretchable surface impact of chemical reaction
Authors: Zeeshan  , Khan Ilyas , Feroz Nosheen , Al-Duais Fuad S. , Mahmoud Omar 
Published: June 2022

AbstractThe present investigation focuses on the characteristics of heat and mass transfer in the context of their applications. There has been a lot of interest in the use of non-Newtonian fluids in engineering and biological disciplines. Having such considerable attention to non-Newtonian fluids, the goal is to explore the flow of Jeffrey non-Newtonian convective fluid driven by a non-linear stretching surface considering the effect of nonlinear chemical reaction effect. The relevant set of difference equations was changed to ordinary equations by using a transformation matrix. To create numerical solutions for velocity and concentration fields, the Runge–Kutta fourth-order method along with the shooting approach is utilized. The innovative fragment of the present study is to scrutinize the magnetized viscous non-Newtonian fluid over extending sheet with internal heat transfer regarding the inspiration of nonlinear chemical reaction effect, which still not has been elaborated on in the available works to date. Consequently, in the restrictive sense, the existing work is associated with available work and originated in exceptional agreement. Graphs depict the effects of various variables on motion and concentration fields, like the Hartman number, Schmidt number, and chemical reaction parameter. The performance of chemical reaction factor, Schmidt number, Hartmann number, and Deborah numbers on velocities component, temperature, and concentration profiles are discussed through graphs. The effect of emerging parameters in the mass transfer is also investigated numerically and 3D configuration is also provided. It is observed that the Deborah numbers and Hartmann numbers have the same effect on velocity components. Also, the thickness of the boundary layer reduces as the Hartmann number increases. As the Schmit number grows, the concentration field decline. For destructive and generative chemical reactions, the concentration fields observed opposite effects. It is also noticed that the surface mas transfer reduces as the Hartmann number rises. The statistical findings of the heat-transfer rate are also documented and scrutinized.
Increasing trend of radiographic features of knee osteoarthritis in rheumatoid arthritis patients before total knee arthroplasty
Authors: Takeda Ryutaro , Matsumoto Takumi , Maenohara Yuji , Omata Yasunori , Inui Hiroshi , Nagase Yuichi , Nishikawa Takuji , Tanaka Sakae 
Published: June 2022

AbstractTo investigate the trend and factors related to the occurrence of osteoarthritis (OA)-like features on knee radiographs of rheumatoid arthritis (RA) patients undergoing total knee arthroplasty (TKA) in the recent decades. To classify antero-posterior knee radiographs into ‘RA’ and ‘OA-like RA’ groups, a deep learning model was developed by training the network using knee radiographs of end-stage arthropathy in RA patients obtained during 2002–2005 and in primary OA patients obtained during 2007–2009. We used this model to categorize 796 knee radiographs, which were recorded in RA patients before TKA during 2006–2020, into ‘OA-like RA’ and ‘RA’ groups. The annual ratio of ‘OA-like RA’ was investigated. Moreover, univariate and multivariate analyses were performed to identify the factors associated with the classification as OA-like RA using clinical data from 240 patients. The percentage of ‘OA-like RA’ had significant increasing trend from 20.9% in 2006 to 67.7% in 2020. Higher body mass index, use of biologics, and lower level of C-reactive protein were identified as independent factors for ‘OA-like RA’. An increasing trend of knee radiographs with OA-like features was observed in RA patients in the recent decades, which might be attributed to recent advances in pharmacotherapy.
Vitamin D and calcium, together and separately, play roles in female reproductive performance
Authors: Safari Hengameh , Hajian Mehdi , Nasr-Esfahani Mohammad Hossein , Forouzanfar Mohsen , Drevet Joël R. 
Published: June 2022

AbstractVitamin D (VD) deficiency reduces the chances of successful fertilization; however, it remains to be validated whether this effect is dependent or not on calcium. To address this question, we generated several situation using a mouse model in which VD content was either increased or decreased in a normo or hypocalcemia context. After the measurement of serum 25-hydroxyvitamin D2, calcium and phosphorus levels, an analysis was carried out in terms of oocytes maturation as well as reproductive performance. VD overdose, despite the fact that it resulted in an increased number of mature oocytes, reduced developmental competence and offspring survival. VD deficiency (VDD), on the contrary, reduced the number and percentage of mature oocytes, blastocyst rate, as well as fertility rate and offspring survival. Hypo-calcemia when VD levels were normal, had a similar effect than VDD. The effects of VDD were reversed by a diet that corrected calcium level. Therefore, both VD overdose (in a context of normal calcium level) VD deficiency as well as hypo-calcemia have an effect on female reproductive function. In conclusion, although closely related, VD and calcium act in part independently of each other in defining the “optimum” for female reproductive performance.
Identification of epithelial and mesenchymal circulating tumor cells in clonal lineage of an aggressive prostate cancer case
Authors: Chai Shoujie , Ruiz-Velasco Carmen , Naghdloo Amin , Pore Milind , Singh Mohan , Matsumoto Nicholas , Kolatkar Anand , Xu Liya , Shishido Stephanie , Aparicio Ana , Zurita Amado J. , Hicks James , Kuhn Peter 
Published: June 2022

AbstractLittle is known about the complexity and plasticity of circulating tumor cell (CTC) biology in different compartments of the fluid microenvironment during tumor metastasis. Here we integrated phenomics, genomics, and targeted proteomics to characterize CTC phenotypic and genotypic heterogeneity in paired peripheral blood (PB) and bone marrow aspirate (BMA) from a metastatic prostate cancer patient following the rapid disease progression, using the High-Definition Single Cell Assay 3.0 (HDSCA3.0). Uniquely, we identified a subgroup of genetically clonal CTCs that acquired a mesenchymal-like state and its presence was significantly associated with one subclone that emerged along the clonal lineage. Higher CTC abundance and phenotypic diversity were observed in the BMA than PB and differences in genomic alterations were also identified between the two compartments demonstrating spatial heterogeneity. Single cell copy number profiling further detected clonal heterogeneity within clusters of CTCs (also known as microemboli or aggregates) as well as phenotypic variations by targeted proteomics. Overall, these results identify epithelial and mesenchymal CTCs in the clonal lineage of an aggressive prostate cancer case and also demonstrate a single cell multi-omic approach to deconvolute the heterogeneity and association of CTC phenotype and genotype in multi-medium liquid biopsies of metastatic prostate cancer.
The RAGE/multiligand axis: a new actor in tumor biology
Authors: Rojas Armando , Schneider Ivan , Lindner Cristian , Gonzalez Ileana , Morales Miguel A. 
Published: June 2022

Abstract
The receptor for advanced glycation end-products (RAGE) is a multiligand binding and single-pass transmembrane protein which actively participates in several chronic inflammation-related diseases. RAGE, in addition to AGEs, has a wide repertoire of ligands, including several damage-associated molecular pattern molecules or alarmins such as HMGB1 and members of the S100 family proteins.
Over the last years, a large and compelling body of evidence has revealed the active participation of the RAGE axis in tumor biology based on its active involvement in several crucial mechanisms involved in tumor growth, immune evasion, dissemination, as well as by sculpturing of the tumor microenvironment as a tumor-supportive niche. In the present review, we will detail the consequences of the RAGE axis activation to fuel essential mechanisms to guarantee tumor growth and spreading.
Transcriptional regulation of plant innate immunity
Authors: Aerts Niels , Chhillar Himanshu , Ding Pingtao , Van Wees Saskia C.M. 
Published: June 2022

Abstract
Transcriptional reprogramming is an integral part of plant immunity. Tight regulation of the immune transcriptome is essential for a proper response of plants to different types of pathogens. Consequently, transcriptional regulators are proven targets of pathogens to enhance their virulence. The plant immune transcriptome is regulated by many different, interconnected mechanisms that can determine the rate at which genes are transcribed. These include intracellular calcium signaling, modulation of the redox state, post-translational modifications of transcriptional regulators, histone modifications, DNA methylation, modulation of RNA polymerases, alternative transcription inititation, the Mediator complex and regulation by non-coding RNAs. In addition, on their journey from transcription to translation, mRNAs are further modulated through mechanisms such as nuclear RNA retention, storage of mRNA in stress granules and P-bodies, and post-transcriptional gene silencing. In this review, we highlight the latest insights into these mechanisms. Furthermore, we discuss some emerging technologies that promise to greatly enhance our understanding of the regulation of the plant immune transcriptome in the future.
Automatic depression recognition by intelligent speech signal processing: A systematic survey
Authors: Wu Pingping , Wang Ruihao , Lin Han , Zhang Fanlong , Tu Juan , Sun Miao 
Published: June 2022

AbstractDepression has become one of the most common mental illnesses in the world. For better prediction and diagnosis, methods of automatic depression recognition based on speech signal are constantly proposed and updated, with a transition from the early traditional methods based on hand‐crafted features to the application of architectures of deep learning. This paper systematically and precisely outlines the most prominent and up‐to‐date research of automatic depression recognition by intelligent speech signal processing so far. Furthermore, methods for acoustic feature extraction, algorithms for classification and regression, as well as end to end deep models are investigated and analysed. Finally, general trends are summarised and key unresolved issues are identified to be considered in future studies of automatic speech depression recognition.
A vector field approach for identifying anomalous human mobility
Authors: Yang Hu , Li Minglun , Guo Bao , Zhang Fan , Wang Pu 
Published: June 2022

AbstractAlthough ordinary human mobility has been extensively studied, anomalous human mobility during emergencies or mass events is not sufficiently understood. The recently proposed vector field approach has shed light on human mobility studies. Here, the authors improve it to analyze anomalous human mobility in mass events. Specifically, the authors develop the anomalous field, the source field, and the dispersion field to identify the crowd gathering location, the start time, and the end time of anomalous human mobility. In addition, the authors propose the decay coefficient and the maximum distance to quantify the influence degree and scope of a mass event. The present approach can be used to capture the spatiotemporal characteristics of human mobility in mass events.
Rental strategy for energy storage to participate in frequency regulation market
Authors: Wang Xiaorong , Yu Yundong , Yan Xiaohe , Liu Nian 
Published: June 2022

AbstractEnergy storage (ES) can help the renewable energy sources to smooth their output and enhance their profits, which promotes the installation of ES. However, it is inappropriate for small‐scale renewable energy communities (REC) to invest costly ES, which requests a new business model to explore the possibility to rent ES for more returns. This paper proposes an ES rental strategy for REC to participate in the frequency regulation market (FRM). Firstly, the FRM is modelled considering the regulation capacity and mileage price. Then, the rental model for REC is built considering capacity rental costs and ES using costs. The correlation of rental capacity with reserved capacity and mileage is built through rental costs and revenue in FRM. The operation method for ES is carried out to maximise the total profits of REC. Finally, the whole model is demonstrated with a REC which has 35 MW photovoltaic and 113 MW wind turbine. The results show that under different rental and market prices, the REC can effectively choose the optimal rental strategy and its profits can mostly be raised by 19.63%.
Chemical Evolution of R-process Elements in Stars (CERES)
Authors: Lombardo Linda , Bonifacio Piercarlo , François Patrick , Hansen Camilla J. , Caffau Elisabetta , Hanke Michael , Skúladóttir Ása , Arcones Almudena , Eichler Marius , Reichert Moritz , Psaltis Athanasios , Koch Hansen Andreas J. , Sbordone Luca 
Published: June 2022

Aims. The Chemical Evolution of R-process Elements in Stars (CERES) project aims to provide a homogeneous analysis of a sample of metal-poor stars ([Fe/H] < –1.5). We present the stellar parameters and the chemical abundances of elements up to Zr for a sample of 52 giant stars.
Methods. We relied on a sample of high signal-to-noise UVES spectra. We determined stellar parameters from Gaia photometry and parallaxes. Chemical abundances were derived using spectrum synthesis and model atmospheres.
Results. We determined chemical abundances of 26 species of 18 elements: Na, Mg, Al, Si, Ca, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Sr, Y, and Zr. For several stars, we were able to measure both neutral and ionised species, including Si, Sc, Mn, and Zr. We have roughly doubled the number of measurements of Cu for stars at [Fe/H] ≤ −2.5. The homogeneity of the sample made it possible to highlight the presence of two Zn-rich stars ([Zn/Fe] ∼ +0.7), one r-rich and the other r-poor. We report the existence of two branches in the [Zn/Fe] versus [Ni/Fe] plane and suggest that the high [Zn/Fe] branch is the result of hypernova nucleosynthesis. We discovered two stars with peculiar light neutron-capture abundance patterns: CES1237+1922 (also known as BS 16085-0050), which is ∼1 dex underabundant in Sr, Y, and Zr with respect to the other stars in the sample, and CES2250-4057 (also known as HE 2247-4113), which shows a ∼1 dex overabundance of Sr with respect to Y and Zr.
Conclusions. The high quality of our dataset allowed us to measure hardly detectable ions. This can provide guidance in the development of line formation computations that take deviations from local thermodynamic equilibrium and hydrodynamical effects into account.
Schröpfen – Therapieoption bei unterschiedlichen Schmerzsymptomatiken
Authors: Brands-Gündling Nadine 
Published: June 2022

ZusammenfassungFunktionelle Störungen können durch die äußerliche Aktivierung der Reflexzonen beeinflusst werden, da diese wiederum auf die inneren Organe wirken. Als ausleitendes Therapieverfahren ist das Schröpfen daher bei vielen verschiedenen Krankheitsbildern einzusetzen. Zur Anwendung kommen das traditionelle blutige Schröpfen, das trockene Schröpfen sowie die Schröpfmassage. Durch die Freisetzung von Endorphinen und den verstärkten Abbau von Prostaglandinen kommt es in der Schröpfzone zu einer Schmerzlinderung. Da die Schröpfkopfbehandlung mehrfach untersucht und als effektiv bewertet wurde und darüber hinaus als nebenwirkungsarmes Verfahren gilt, erfährt sie in den letzten Jahren eine Wiedergeburt in der manualtherapeutischen Praxis.
Fallbericht: Scheinbarer Therapieerfolg bei Covid-19
Authors: Colling Christoph 
Published: June 2022

SummaryWährend der Covid-19-Pandemie war eine Zunahme von Angst und Depressionen zu beobachten. Die Patienten suchen nach medizinischer Unterstützung, auch bei psychischen und psychosomatischen Symptomen. Am Beispiel eines Falles passagerer Spontanbesserung einer Covid-19-assoziierten Hyposmie nach körpertherapeutischer Komplexbehandlung in der psychosomatischen Rehabilitation diskutiert der Beitrag den scheinbaren oder tatsächlichen Therapieerfolg einer multimodalen Behandlung.
Mönchspfeffer
Authors: Niedenthal Tobias , Puchtler Elke 
Published: June 2022

SummaryMönchspfeffer (Vitex agnus-castus) ist Arzneipflanze des Jahres 2022 in Deutschland – Anwendung in der Frauenheilkunde bei Symptomen des prämenstruellen Syndroms (PMS), Regeltempoanomalien und Mastodynie
Dynamically Self-Assembled Supramolecular Probes in Liposomes
Authors: Hennig Andreas 
Published: June 2022

Liposomes are artificial vesicles, in which an aqueous inner compartment is separated from its environment by a phospholipid membrane. They have been extensively studied as cell membrane models and offer the possibility to confine molecules and chemical reactions to a small sub-micrometer-sized volume. This short review provides an overview of liposome-encapsulated, dynamically self-assembled, supramolecular structures, in which the assembly and disassembly of the supramolecular structures can be followed by optical spectroscopic methods. This includes self-quenched fluorescent dyes and dye/quencher pairs, helical stacks of guanosine nucleotides, dynamic covalent boronate esters, and supramolecular host–guest complexes. The resulting liposomes are typically used to study membrane transport processes, but the results summarized herein also serve as a potential blueprint for studying dynamic self-assembly in confined spaces by optical spectroscopic methods.Table of content:1 Introduction2 Probes Based on Fluorescence Quenching3 Chirogenic G-Quartet Probes4 Chromogenic Probes Using Dynamic Covalent Bonds5 Self-Assembled Host–Dye Reporter Pairs6 Conclusions and Outlook
Synthesis of the Key Skeleton of Phosphoeleganin
Authors: Goswami Rajib Kumar , Mandal Gour Hari , Saha Dhiman , Auddy Sourya Shankar 
Published: June 2022

AbstractThe asymmetric synthesis of the key skeleton of phosphoeleganin has been achieved for the first time by using a convergent approach. The salient features of this synthesis include amidation to install a glycine amide at the C-1 position, Wittig olefination to access the C5–C6 bond, Julia–Kocienski olefinations to prepare the C9–C10 and C13–C14 bonds, and a Takai olefination and a Sonogashira coupling to construct the C17–C18 and C18–C19 bonds, respectively. The route disclosed is highly modular, which will permit the synthesis of various analogues, useful for structure–activity relationship studies on phosphoeleganins.
Ionizing Radiation Exposure in Children with Vesicoureteral Reflux: Should We Be Alarmed?
Authors: Fernandez Nicolas , Villarraga Luis-Gabriel , Chavarriaga Julian , Prada Juan , Restrepo Valeria , Perez Jaime 
Published: June 2022

Abstract
Objectives Ionizing radiation imaging is commonly used for diagnosis and follow up in children with vesicoureteral reflux (VUR). We aim to measure the effective dose (mSv) in patients with VUR.
Methods We reviewed our electronic database of patients under 8-years-old with VUR. Primary endpoint was to calculate the effective radiation dose (ED). Absolute frequencies and percentages were reported for global qualitative variables. This study conducted a logistic regression model to calculate the odds ratio for radiation exposure. Analysis was performed using STATA version 14.0 (StataCorp LLC, College Station, TX, EEUU).
Results A total of 140 patients were found, 97 were assessed for eligibility. We included 59 patients in the final analysis. Mean age was 20 ± 17.9 months, 66% were females. Most cases of VUR were bilateral (44%) and high grade (93.4%). The lowest number of studies per patient was two, with a minimum radiation of 5.7 mSv. The highest radiation was estimated at 20.7 mSv corresponding to a total of five studies. Logistic regression showed that highest grades of VUR and age of first UTI episode were associated with higher ED (OR, 1.7; 95% CI, 0.87-3.31), (OR 1.02; 95% CI 0.97-1.07) respectively. A mean ED for children with VUR was estimated of 5.5 ± 3 mSv/year.
Conclusion In our study, the children with VUR were exposed to 5.5 mSv/year without counting the natural background radiation, which is alarming, and we believe should raise awareness worldwide in how we are unnecessarily diagnosing indolent VUR cases and following patients.
A Rabbit Model for Peripheral Nerve Reconstruction Studies Avoiding Automutilation Behavior
Authors: Sorkin Jonathan A. , Rechany Ziv , Almog Mara , Dietzmeyer Nina , Shapira Yuval , Haastert-Talini Kirsten , Rochkind Shimon 
Published: June 2022

Abstract
Background The rabbit sciatic nerve injury model may represent a valuable alternative for critical gap distance seen in humans but often leads to automutilation. In this study, we modified the complete sciatic nerve injury model for avoiding autophagy.
Materials and Methods In 20 adult female New Zealand White rabbits, instead of transecting the complete sciatic nerve, we unilaterally transected the tibial portion and preserved the peroneal portion. Thereby loss of sensation in the dorsal aspect of the paw was avoided. The tibial portion was repaired in a reversed autograft approach in a length of 2.6 cm. In an alternative repair approach, a gap of 2.6 cm in length was repaired with a chitosan-based nerve guide.
Results During the 6-month follow-up period, there were no incidents of autotomy. Nerve regeneration of the tibial portion of the sciatic nerve was evaluated histologically and morphometrically. A clear difference between the distal segments of the healthy contralateral and the repaired tibial portion of the sciatic nerve was detectable, validating the model.
Conclusion By transecting the isolated tibial portion of the rabbit sciatic nerve and leaving the peroneal portion intact, it was possible to eliminate automutilation behavior.