bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficiency in design and production to achieve sustainable development challenges in the automobile industry: Modular electric vehicle platforms
Authors: Lampón Jesús F. 
Published: July 2022

AbstractElectric vehicles have been based on a new product architecture: modular electric vehicle platforms (MEVPs). Through a case study, this paper uses efficiency and sustainability criteria to analyse this modular architecture as implemented by three automobile manufacturers in their European production networks. The results show that MEVPs have been adopted to achieve the efficiency of mass‐production electric vehicles in order to comply with regulatory environmental requirements. MEVPs are designed with structural compatible modules, an electric drive system architecture and modular batteries that can be adapted to each vehicle. These designs are focused on limiting energy consumption by reducing weight with the use of high‐performance materials or extra‐thin batteries. Some of these MEVPs use fewer components in their design to facilitate disassembly and recycling. This new modular architecture has been implemented through compatible, flexible production systems accompanied by different sustainable production initiatives. The production system has incorporated carbon‐neutral production processes or circular economy production models, which include remanufacturing and reuse. Networks resulting from these new MEVPs are geographically concentrated and are not conditioned by location factors. The roles of the plants have been mainly driven by economies of scale to achieve high‐performance specialised products and high volumes. These plants play a role as hubs for electric vehicle production in the manufacturers' European production networks.
A classification scheme to improve conclusion instability using Bellwether moving windows
Authors: Mensah Solomon , Kudjo Patrick Kwaku 
Published: July 2022

AbstractContextThe use of a subset of recently completed and exemplary data, namely, Bellwether moving window (BMW) has proven successful to result in improved accuracy in software effort estimation (SEE). These outcomes were achieved based on the theory that estimation outcome of a future event depends on previous events. Thus, the existence of a BMW yield improved prediction accuracy for new project estimation. However, the conclusion instability problem across learners still threatens the reliability of SEE for new projects. Such instability concerns are attributed to the data subset considered for the training and validation needs of learners.ObjectiveTo investigate whether the use of BMWs together with an effort classification scheme can minimize the conclusion instability problem across learners.MethodWe apply a Bellwether method comprising of three operators, namely, SORT+CLUSTER, GENERATE_TPM, and APPLY to sample the BMW from a pool of chronological projects from the Maxwell and International Software Benchmarking Standards Group (ISBSG) datasets. The sampled BMW is benchmarked against the entire collection of preprocessed projects, namely, growing portfolio to evaluate prediction and classification accuracy across a set of learners–ElasticNet regression, deep neural networks, and automatically transformed linear model.Results(1) BMW exists in the studied projects and (2) training the learners with a BMW of average window size 28.5%–75.5% of the growing portfolio (not older than 3 years) relatively minimizes the conclusion instability of prediction results.ConclusionWhen BMWs are available, we recommend their use for estimating the effort for a new project to minimize the conclusion instability problem.
Effects of a phthalate metabolite mixture on both normal and tumoral human prostate cells
Authors: Cavalca Alexandre M. B. , Aquino Ariana M. , Mosele Francielle C. , Justulin Luis A. , Delella Flávia K. , Flaws Jodi A. , Scarano Wellerson R. 
Published: July 2022

AbstractPhthalates represent a group of substances used in industry that have antiandrogenic activity and are found in different concentrations in human urine and plasma. More than 8 million tons of phthalates are used each year, predominantly as plasticizers in polyvinyl chloride (PVC) products. Phthalates are widely used in everyday consumer products and improperly discarded into the environment. Furthermore, in vivo studies carried out in our laboratory showed that a mixture of phthalates, equivalent to the mixture used in this study, deregulated the expression of genes and miRNAs associated with prostatic carcinogenic pathways. Thus, this study was designed to establish an in vitro model to assess pathways related to cell survival, proliferation, apoptosis, and biosynthesis of miRNAs, using both normal and tumoral prostatic epithelial cells exposed to an environmentally relevant mixture of phthalate metabolites. Tumor (LNCaP) and normal (PNT‐2) prostatic epithelial cell lines were exposed for 24 and 72 h to vehicle control or the phthalate mixture. The selected metabolite mixture (1000 μmol/L) consisted of 36.7% monoethyl phthalate (MEP), 19.4% mono(2‐ethylhexyl) phthalate (MEHP), 15.3% monobutyl phthalate (MBP), 10.2% monoisobutyl phthalate (MiBP), 10.2% monoisononyl phthalate (MiNP), and 8.2% monobenzyl phthalate (MBzP). Gene expression was performed by qRT‐PCR and cell migratory potential was measured using cell migration assays. Our results showed that the mixture of phthalates increased cell turnover, oxidative stress, biosynthesis, and expression of miRNAs in LNCaP cells; thus, increasing their cellular expansive and migratory potential and modulating tumor behavior, making them possibly more aggressive. However, these effects were less pronounced in benign cells, demonstrating that, in the short term, benign cells are able to develop effective mechanisms or more resistance against the insult.
Jeong and the Interrelationality of Self and Other in Korean Buddhist Cinema
Authors: Suh Sharon A. 
Published: July 2022

AbstractThis chapter discusses the role of jeong in Korean Buddhist films that explore the Mahayana premise that ultimate freedom is not to be found in an escape from the world of suffering, but rather in its compassionate embrace. Focusing on Im Kwon-taek’s film AjeAje Bara Aje, this chapter suggests that the jeong fused spiritual kinship between a Buddhist disciple and her superior facilitates the former’s recognition and embrace of the abject as none other than the self. This chapter views jeong as an ethical response to the other that finds resonance with Buddhist concepts of emptiness and interdependence.
Dasan Jeong Yagyong on Emotions and the Pursuit of Sagehood
Authors: Baker Don 
Published: July 2022

AbstractDasan Jeong Yagyong (1762–1836) spent much of his life trying to understand the role emotions play in stimulating both moral and immoral behavior. He did not limit his investigation of moral psychology to the standard list of Seven Emotions but also looked at such emotions as resentment and apprehension. He concluded that in order to ensure our emotions direct us to act appropriately, we need to cultivate an attitude of caution and apprehension. Grounded in such an attitude, our heart-mind will control and integrate the inclinations (which he believes constitute human nature) and emotions which inspire us to act selflessly.
Korean Social Emotions: Han (한 恨), Heung (흥 興), and Jeong (정 情)
Authors: Park Iljoon 
Published: July 2022

AbstractThis chapter deals with Korean social emotions in terms of the coupling structure of han (恨) and heung (興), and of jeong (情) and non-attachment (無心). This dynamic coupling is called poong-ryu (風流), in which people exchange their emotions and feelings so that people and things correspond to each other. The Dao of poong-ryu lies in “making-friends-and-living-together” beyond the differences of doctrines or teachings. This chapter argues that Korean emotional culture of poong-ryu can have healing effects upon the self by the natural self-so-ing (自然) in this digitally connected and socially distanced world under the pandemic.
Nachhaltige Vergütung der B‑Zentren für Seltene Erkrankungen in Deutschland – Status quo und Lösungsansätze
Authors: Litzkendorf Svenja , Eidt-Koch Daniela , Zeidler Jan , Graf von der Schulenburg Johann-Matthias 
Published: July 2022

Zusammenfassung
Hintergrund
Um eine spezialisierte Versorgung von Menschen mit seltenen Erkrankungen (sE) zu gewährleisten, wurden zahlreiche Zentren für Seltene Erkrankungen (ZSE) gegründet. Für die ambulante Behandlung von Betroffenen in Krankenhäusern steht dabei eine Vielzahl von Versorgungs- und Vergütungsformen zur Verfügung. Studien zu einzelnen sE ergaben bereits Hinweise auf Defizite in Bezug auf eine kostendeckende Vergütung der ZSE.

Ziel der Arbeit
Untersuchung der aktuellen Versorgungs- und Vergütungsstrukturen in den ZSE und die Entwicklung von Ansätzen für zukünftige nachhaltige Vergütungsstrukturen.

Material und Methoden
Mittels Fragebogenerhebung wurden zunächst ZSE in Deutschland zu ihrer Versorgungs- und Vergütungsform befragt. Im Rahmen zweier Fokusgruppen- und eines Experteninterviews mit Vertreter:innen der ZSE, der Kostenträger, der Gesundheitspolitik sowie Patient:innen wurden im Anschluss die aktuellen Versorgungs- und Vergütungsformen, Möglichkeiten der zukünftigen Gestaltung der Versorgung von Menschen mit sE sowie Ansätze für eine leistungsorientierte Vergütung diskutiert. Das Material wurde inhaltsanalytisch nach Kuckartz ausgewertet.

Ergebnisse und Diskussion
39 Zentren beteiligten sich an der Fragebogenerhebung. 38 % dieser Zentren werden über eine Pauschale für Hochschulambulanzen (HSA) vergütet, deren Höhe stark variiert. 41 % weisen eine Mischvergütung aus HSA-Pauschale und weiteren Vergütungsformen auf. In den Interviews wurde eine Unterdeckung der Kosten in den ZSE mit Auswirkungen auf die Patientenversorgung benannt und zur Sicherstellung einer nachhaltigen Versorgung Handlungsbedarf zur Weiterentwicklung der Vergütungsstrukturen festgestellt. Eine „Sonderpauschale für sE“, die den besonderen zeitlichen Bedarf in der Versorgung von Menschen mit sE abbildet, wurde als möglicher nachhaltiger Vergütungsansatz präferiert.
No difference between mobile and fixed bearing in primary total knee arthroplasty: a meta-analysis
Authors: Migliorini Filippo , Maffulli Nicola , Cuozzo Francesco , Pilone Marco , Elsner Karen , Eschweiler Jörg 
Published: July 2022

Abstract
Purpose
Both mobile (MB) and fixed (FB) bearing implants are routinely used for total knee arthroplasty (TKA). This meta-analysis compared MB versus FB for TKA in terms of implant positioning, joint function, patient reported outcome measures (PROMs), and complications. It was hypothesised that MB performs better than FB implants in primary TKA.

Methods
This meta-analysis was conducted according to the 2020 PRISMA statement. In February 2022, the following databases were accessed: Pubmed, Web of Science, Google Scholar, Embase. All the randomized clinical trials (RCTs) comparing mobile versus fixed bearing for primary TKA were considered.

Results
Data from 74 RCTs (11,116 procedures) were retrieved. The mean follow-up was 58.8 (7.5 to 315.6) months. The MB group demonstrated greater range of motion (ROM) (P = 0.02), Knee Society Score (KSS) score (P < 0.0001), and rate of deep infections (P = 0.02). No difference was found in implant positioning: tibial slope, delta angle, alpha femoral component angle, gamma femoral component angle, beta tibial component angle, tibiofemoral alignment angle, posterior condylar offset, radiolucent lines. No difference was found in duration of the surgical procedure. No difference was found in the following PROMs: Oxford Knee Score (OKS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), visual analogue scale (VAS), function and pain subscales of the KSS score. No difference was found in the rate of anterior knee pain, revision, aseptic loosening, fractures, and deep vein thrombosis.

Conclusion
There is no evidence in support that MB implants promote greater outcomes compared to FB implants in primary TKA.

Level of evidence
Level I.
Phytohormones in Sweet Cherry Buds During Winter Rest and Bud Development
Authors: Götz Klaus-Peter , Chmielewski Frank-M. , Tarkowská Danuše , Pěnčík Aleš , Novák Ondřej 
Published: July 2022

AbstractThis (two-season) study was undertaken to assess the involvement of gibberellins (GAs), cytokinins (CKs), and auxins (AX) in dormancy of the sweet cherry buds ‘Summit’. Our hypothesis consisted in the assumption that representatives of these hormone groups are able to mark the transition between different dormancy phases. Changes in the transition between endo- and ecodormancy and the stages of ontogenetic development were not recognizable by bioactive GA1, GA5, GA7. The transient increase of GA3 during ecodormancy might be interpreted as an indication of the preservation of ecodormancy. The content of the biological active bases tZ, cZ, and DHZ was equal between endo- and ecodormancy. However, the content increased significantly in the first phase of ontogenetic development. The summation of the representatives of the various CKs (total iP-type, total tZ-type, total CK bases, total CK ribosides, total CK nucleotides, total O-glucosides, total N-glucosides, and total CKs) showed no differences regarding their levels during endo- and ecodormancy. These values increased markedly in the subsequent phase. AX increased after ecodormancy. By contrast, from side green until open cluster no differences occurred. As shown for AX, the content of oxIAA increased after ecodormancy. The content of IAAsp was low during endodormancy and increased transiently during ecodormancy and early ontogenetic development. This study revealed that no changes in the content of different bioactive GAs (exception GA3), CKs, and AX occurred during winter rest, and more precisely, during endo- and ecodormancy. These metabolites, therefore, are not suitable to differentiate between these dormancy phases. The ontogenesis is accompanied by specific changes in the content of bioactive molecules, precursors, and conjugation products.
Principles of enhanced recovery in gastrointestinal surgery
Authors: Roulin Didier , Demartines Nicolas 
Published: July 2022

Abstract
Background
To reduce the impact of surgery-related stress, enhanced recovery after surgery (ERAS) pathways have been developed since over 15 years with subsequent improved postoperative outcome. This multimodal and evidence-based perioperative approach has spread to all fields of gastrointestinal surgery, from esophagus, stomach, duodenum and pancreas, liver, small intestine and colon, and rectum, as well as for other specialties like vascular and cardia surgeries or neurosurgery, among others.

Purpose
The aim of this state-of-the-art article is to assess current state of evidence on perioperative management specifically in gastrointestinal surgery, with a focus on surgery-related aspects, outcome benefit, and future directions.

Conclusion
The surgical team must promote continuous improvement of the patient’s ERAS compliance to ensure optimal perioperative care. Everyday clinical practice should be performed according to latest evidence-based medicine and challenging surgical dogma. Moreover, the surgeon must lead and support a multidisciplinary and collaborative teamwork tailored to patient’s need especially with anesthetists and nursing staff.
Comparative effectiveness and safety of glargine 300 U/mL versus degludec 100 U/mL in insulin-naïve patients with type 2 diabetes. A multicenter retrospective real-world study (RESTORE-2 NAIVE STUDY)
Authors: Fadini Gian Paolo , Buzzetti Raffaella , Nicolucci Antonio , Larosa Monica , Rossi Maria Chiara , Cucinotta Domenico ,   On behalf of the RESTORE-2 Study Group, Enrico Gabellieri , Alberto Marangoni , Uberto Pagotto , Claudio Bongiorno , Concetta Gatta , Andrea Del Buono , Olga Lamacchia , Pasquale Maiellaro , Daniela Antenucci , Gabriele Brandoni , Francesca Borroni , Giovanna Gregori , Antonino Di Benedetto , Giuseppe Placentino , Franco Cavalot , Cristina Barale , Paolo Fadini Gian , Paola Del Sindaco , Chiara Di Loreto , Roberto Anichini , Giuseppe Citro , Paola D’Angelo , Silvia Carletti , Raffaella Buzzetti , Sara Sterpetti , Mignogna Carmen , Paolo Elli 
Published: July 2022

Abstract
Aims
This study assessed comparative effectiveness of glargine 300 U/mL (Gla-300) versus degludec 100 U/mL (Deg-100) in insulin-naïve patients with T2D.

Methods
This is a retrospective, multicenter, non-inferiority study based on electronic medical records. All patients initiating Gla-300 or Deg-100 were 1:1 propensity score-matched (PSM). Linear mixed models were used to assess the changes in continuous endpoints. Incidence rates (IR) of hypoglycemia were compared using Poisson’s regression models.

Results
Nineteen centers provided data on 357 patients in each PSM cohort. HbA1c after 6 months (primary endpoint) decreased by − 1.70% (95%CI − 1.90; − 1.50) in Gla-300 group and − 169% (95%CI − 1.89; − 1.49) in Deg-100 group, confirming non-inferiority of Gla-300 versus Deg-100. Fasting blood glucose (BG) decreased by ~60 mg/dl in both groups; body weight remained unchanged. In both groups, the mean starting dose was 12U (0.15U/kg) and it was slightly titrated to 16U (0.20U/kg). IR (episodes per patient-months) of BG ≤70 mg/dl was 0.13 in Gla-300 group and 0.14 in Deg-100 group (p=0.87). IR of BG <54 mg/dL was 0.02 in both groups (p=0.49). No severe hypoglycemia occurred.

Conclusion
Initiating Gla-300 or Deg-100 was associated with similar improvements in glycemic control, no weight gain and low hypoglycemia rates, without severe episodes during 6 months of treatment.
Serial visual reversal learning in harbor seals (Phoca vitulina)
Authors: Erdsack Nicola , Dehnhardt Guido , Hanke Frederike D. 
Published: July 2022

AbstractProgressively improving performance in a serial reversal learning (SRL) test has been associated with higher cognitive abilities and has served as a measure for cognitive/behavioral flexibility. Although the cognitive and sensory abilities of marine mammals have been subject of extensive investigation, and numerous vertebrate and invertebrate species were tested, SRL studies in aquatic mammals are sparse. Particularly in pinnipeds, a high degree of behavioral flexibility seems probable as they face a highly variable environment in air and underwater. Thus, we tested four harbor seals in a visual two-alternative forced-choice discrimination task and its subsequent reversals. We found significant individual differences in performance. One individual was able to solve 37 reversals showing progressive improvement of performance with a minimum of 6 errors in reversal 33. Two seals mastered two reversals, while one animal had difficulties in learning the discrimination task and failed to complete a single reversal. In conclusion, harbor seals can master an SRL experiment; however, the performance is inferior to results obtained in other vertebrates in comparable tasks. Future experiments will need to assess whether factors such as the modality addressed in the experiment have an influence on reversal learning performance or whether indeed, during evolution, behavioral flexibility has not specifically been favored in harbor seals.
Non-invasive predictors of axillary lymph node burden in breast cancer: a single-institution retrospective analysis
Authors: Ngai Victoria , Tai Justina Cheh Juan , Taj Saima , Khanfar Heba , Sfakianakis Elefterios , Bakalis Athanasios , Baker Rose , Ahmed Muneer 
Published: July 2022

Abstract
Purpose
Axillary staging is an important prognostic factor in breast cancer. Sentinel lymph node biopsy (SNB) is currently used to stage patients who are clinically and radiologically node-negative. Since the establishment that axillary node clearance (ANC) does not improve overall survival in breast-conserving surgery for patients with low-risk biological cancers, axillary management has become increasingly conservative. This study aims to identify and assess the clinical predictive value of variables that could play a role in the quantification of axillary burden, including the accuracy of quantifying abnormal axillary nodes on ultrasound.

Methods
A retrospective analysis was conducted of hospital data for female breast cancer patients receiving an ANC at our centre between January 2018 and January 2020. The reference standard for axillary burden was surgical histology following SNB and ANC, allowing categorisation of the patients under ‘low axillary burden’ (2 or fewer pathological macrometastases) or ‘high axillary burden’ (> 2). After exploratory univariate analysis, multivariate logistic regression was conducted to determine relationships between the outcome category and candidate predictor variables: patient age at diagnosis, tumour focality, tumour size on ultrasound and number of abnormal lymph nodes on axillary ultrasound.

Results
One hundred and thirty-five patients were included in the analysis. Logistic regression showed that the number of abnormal lymph nodes on axillary ultrasound was the strongest predictor of axillary burden and statistically significant (P = 0.044), with a sensitivity of 66.7% and specificity of 86.8% (P = 0.011).

Conclusion
Identifying the number of abnormal lymph nodes on preoperative ultrasound can help to quantify axillary nodal burden and identify patients with high axillary burden, and should be documented as standard in axillary ultrasound reports of patients with breast cancer.
Parametric excitation suppression in a floating cylinder via dynamic vibration absorbers: a comparative analysis
Authors: Davidson Josh , Kalmár-Nagy Tamás , Habib Giuseppe 
Published: July 2022

AbstractParametric excitation in the pitch/roll degrees of freedom (DoFs) can induce dynamic instability in floating cylinder-type structures such as spar buoys, floating offshore wind or wave energy converters. At certain frequency and amplitude ranges of the input waves, parametric coupling between the heave and pitch/roll DoFs results in undesirable large amplitude rotational motion. One possible remedy to mitigate the existence of parametric resonance is the use of dynamic vibration absorbers. Two prominent types of dynamic vibration absorbers are tuned mass dampers (TMDs) and nonlinear energy sinks (NESs), which have contrasting properties with regard to their amplitude and frequency dependencies when absorbing kinetic energy from oscillating bodies. This paper investigates the suppression of parametric resonance in floating bodies utilizing dynamic vibration absorbers, comparing the performance of TMDs against NESs for a test case considering a floating vertical cylinder. In addition to the type of dynamic vibration absorber utilized, the paper also examines the DoF which it acts on, comparing the benefits between attaching the vibration absorber to the primary (heave) DoF or the secondary (pitch) DoF. The results show that the TMD outperforms the NES and that it is more effective to attach the vibration absorber to the heave DoF when eliminating parametric resonance in the pitch DoF.