bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technology Focus: Sand Management (October 2022)
Authors: Abbasy Imran 
Published: November 2022

A step change is noticeable in the quality of papers from the previous 2 years. First, the papers have better technical content; second, they are pushing the boundaries of currently accepted technologies and mores. Perhaps this is because of a desire to produce from ever-more-difficult and -challenging wells. The current energy crisis and higher prices as a result have encouraged the application of new technology, which, in a low-energy-price environment, generally takes a back seat. This is a good thing for the technology junkies of this world.
A few technology areas are worth mentioning. Although ceramic sand screens have been around for a few years, this year there were more than the usual number of papers on this technology. For those interested in probing the operating limits and life span of these screens, paper OTC 31896 is worth reading.
Sand consolidation continues to be a subject of interest, perhaps because of its noninvasive nature. Besides, it is potentially low-cost and has been used widely with success. This year, there were 10 papers on the subject. An interesting paper worthy of mention is SPE 208808, which introduces a novel temperature-activated, “green” consolidation fluid.
In paper SPE 207193, the authors propose a fast and accurate machine-learning algorithm to predict the onset of sanding in sandstone formations. The algorithm uses 11 geological and reservoir parameters that directly affect sand production. The answer is binary (i.e., sand production will or will not occur). This could be a great tool for completion engineers.
Finally, there was extensive coverage of sand management in the topsides, an area often overlooked. This trend is encouraging. Paper OTC 31554 is thought-provoking. It discusses the first field installation of a patented device that modifies the flow profile to alleviate the impact of solids at critical points.
I hope you enjoy the papers.
Recommended additional reading at OnePetro: www.onepetro.org.
OTC 31872 Improving Erosion Wear Life of Completion Equipment in High-Flow-Rate Conditions by Numerical Design Optimization for Influx Equalization by Gocha G. Chochua, Schlumberger, et al.
SPE 208839 Completion Standardization Using Conformable Sand-Screen Technology in Multilayered Ultrafine Sand Reservoir by Ricardo Gomez Simancas, Cabinda Gulf Oil, et al.
SPE 208845 A Comprehensive Review of Sand-Retention Test Methods and Data Analysis With a Focus on Application by Tanner Linden, Constien and Associates, et al.
Detecting Misbehaving Nodes in Manet in Cluster Node Using FC Based on-Demand Routing Protocol
Authors: Vithiyanathan Rajesh Kannan , Arputham Charles 
Published: November 2022

Abstract
Many of developed researchers focused in the field of ad hoc temporary network because of this only network is effectively communication from source to destination in the time of un-avoidance or natural issues. Mobile Ad hoc Networks (MANET) affects for many challenging issue such as multipath routing, wasted energy, wasted bandwidth, attacks, drop, loss etc. Multipath is one of un-avoided concept of MANET they lead to easy communication between two nodes using intermediate hops due to problem of obstacle in active path or network this types of topology is very flexible share information through different paths. Part of in this work implemented Cluster Head based On-Demand Routing Protocol called Cluster Head based Ad hoc On-Demand Distance Routing Protocol using Fuzzy Controller (FCH-AODV) they work path selection routing between source and destination via active intermediate nodes for mobile network specially developed to aware head node compare to existing Ad hoc On-Demand Distance Routing Protocol (AODV), implement and tested using NS2.
The Relationship Between Students' Metacognition and Graphic Organisers: A Scoping Review
Authors: Huang Yueyi , Tsapali Maria 
Published: November 2022

Abstract
Metacognition is a complex cognitive function that is considered to be one of the most important goals of education. One of the most effective ways to enhance metacognition suggested in the literature is using graphic organisers. However, it is unclear how graphic organisers can facilitate metacognition and what the relationship between them is. The present study is a scoping review that fills this gap and maps the current literature regarding metacognition, graphic organisers and their relationship. Online databases were used to identify papers, from which 25 of them were selected. The results of the review show that there are three types of graphic organisers-metacognition relationship: (1) graphic organisers are used in interventions to enhance metacognition, (2) a combination of graphic organisers and metacognition activities is used in interventions to enhance learning outcomes, and (3) graphic organisers are used to evaluate metacognition. The review also highlights the need for further studies in the field that use experimental design and include younger learners, and diverse subjects, learning domains and contexts. The present study concludes by offering instructional insights for designing metacognition interventions by utilising graphic organisers as aids.
Gallic acid promotes polarization of M2 macrophages through p38MAPK/STAT6 signaling pathway in vitro
Authors: Gu Xiaoli , Zhu yanan , Wang linyuan , Guan Ning , Li Chenguang 
Published: November 2022

Abstract
Background Interleukin-4 (IL-4)-stimulated M2 macrophage activation contributes to anti-inflammatory activity, tissue repair, and wound healing. Gallic acid (GA) the effect and underlying mechanism of gallic acid on the polarization of M2 macrophages remain to be elucidated.
Methods and Results We constructed an M2 macrophages polarization model induced by 20 ng/mL IL-4, which were incubated alone (M0) or with GA at 10 µM, 20 µM, 30µM, and 40 µM for 24 h or pretreated with the p38MAPK inhibitor SB202190. We showed that F4/80+CD206+ M2 macrophages proportion (flow cytometry), IL-10, Arg1, and TGF-β1 expression levels (real-time PCR and Western blotting), and STAT6 and p38MAPK phosphorylation levels (Western blotting) were significantly (P < 0.01) higher in the GA group, as compared with the IL-4 group. After pretreatment with SB202190, M2-type macrophages proportion and their associated factors expression was significantly (P < 0.01) reduced, as compared with those in the GA group, but they were comparable (P > 0.05) with the IL-4 group.
Conclusions Results of the present study suggest that GA promotes M2 macrophages polarization in a concentration-dependent manner, through the p38MAPK/STAT6 signaling pathway, providing new clues for cell-targeted therapies in M2 macrophages-mediated inflammatory diseases.
Antithrombotic therapy in patients after TAVR: an up-date meta-analysis
Authors: Wang Qiong , Shen Li , Xu Danyan , Wang Yurong 
Published: November 2022

Abstract
Background: Antiplatelet and anticoagulation therapy can reduce the risk of thrombosis in patients after TAVR, but there is no consensus on the risk of bleeding, and current antithrombotic regimens for patients after TAVR are based on empirical treatment with no expert consensus. We performed a meta-analysis to summarize the efficacy and safety of mono-antiplatelet, mono-anticoagulation, and dual-antiplatelet therapy in patients after TAVR alone and NOACs, VKA, and OAC plus SAPT for patients with TAVR combined with AF.
Methods: We searched PubMed, Embase, and the Cochrane Central Register of Controlled Trials, and then performed a systematic review of all randomized controlled trials and cohort studies.
Results: In patients with TAVR without an indication for oral anticoagulants, SAPT and DAPT did not differ significantly in all-cause mortality, stroke events in the opposite direction, while SAPT was associated with a lower bleeding rate (OR: 1.79, 95% CI: 1.04-3.09, p = 0.04), and OAC and SAPT, although not different in each endpoint event, were not recommended due to their safety Use. In patients with an indication for oral anticoagulation, NOACs did not differ significantly in all-cause mortality, bleeding and embolic events compared with VKA. OAC + SAPT significantly increased the risk of bleeding compared with OAC alone (OR: 1.33, 95% CI: 1.14-1.55, p = 0.0003).
Conclusions:SAPT treatment reduces the risk of bleeding and does not increase the risk of mortality or stroke in patients with TAVR without an indication for oral anticoagulants; NOACs is the preferred option for patients with TAVR combined with AF with an indication for oral anticoagulants and is not recommended to be added to antiplatelet drugs.
SPRAG: Building and Benchmarking a Short Programming Related Answer Grading Dataset
Authors: Bonthu Sridevi , S S Rama , Prasad M. H.M. Krishna 
Published: November 2022

Abstract
Automated Short Answer Grading (ASAG) is one of the most studied applications of NLP in the education domain. Most of the work in this area focuses on natural language responses. The main contribution of this work is the building and benchmarking of the Short Programming Related Answer Grading dataset. The corpus contains questions and answers taken from python programming subjects involving symbols, keywords, and no grammar. We propose data collection, preprocessing, and annotating methods that enable the creation of the corpus. This paper also provides an initial analysis of the corpus. A range of pre-trained sentence-transformer models are evaluated on the dataset for classification. We find that fine-tuning the pre-trained models results in the best performance for binary classification. The dataset is freely available to the public.
Characterization of dokha tobacco species and microbial communities using DNA barcoding
Authors: Leinberger-Jabari Andrea , Walwyn-Pollard Odaelys , Subramanian Mira , Garbarino Jeanne , Ali Raghib , Sherman Scott E. 
Published: November 2022

Abstract
Little is known about dokha tobacco, an emerging alternative tobacco product that is quickly gaining popularity in the Arabian Gulf, Middle East, and Europe. Dokha is a loose tobacco sold in small jars and is smoked in a small pipe called a “midwakh”. The aim of this study was to analyze the biological components of dokha samples using DNA barcoding, sequencing, and microbial assays.
Fifteen dokha samples were collected from retail locations in the UAE and US. DNA was extracted from samples and analyzed using both DNA barcoding and whole genome sequencing. DNA barcoding was achieved by PCR amplification using rbcL primer sets. BLAST and BOLD plant libraries were used for sample identification. Whole genome sequence analysis was completed using the OneCodex taxonomic classification tool.
DNA extraction yielded a range of 0.5 – 4ng/ul from 100mg tobacco samples. All samples were identified within the genus Nicotiana and had hits on various species. There were no hits on other plant species. Whole genome sequencing showed bacterial colonization on a number of the samples. Bacterial species included novel strains of Clostridium (C105KSO15, C105KSO14, and C105KSO14), Campylobacter, and Streptococcus.
Analysis of these samples revealed that dokha tobacco consists of pure Nicotiana tobacco leaf, and is not mixed with other substances. Further microbial communities exist in much the same pattern as other commercial tobacco products, which suggests this is a harmful tobacco product.
Designing Accountability Measures for Health Professionals: Results from a community-based micro-credential: Case Study on Indigenous Cultural Safety
Authors: Mashford-Pringle Angela , Tan Sharon , Stutz Sterling , Tjong Gabriel 
Published: November 2022

Abstract

BackgroundThere is a widespread commitment to implementing anti-Indigenous racism with health organizations by introducing cultural safety staff training. In partnership with a public health unit in Ontario, Canada, we developed an evaluation tool to assess the performance of staff who completed an online Indigenous cultural safety education course.MethodsWe co-created a professional development accountability checklist. Five areas of interest were identified: terminology, knowledge, awareness, skills, and behaviours. The checklist comprises of 37 indicators linked to our community collaborators’ intended goals as defined in our partnership agreement.ResultsThe Indigenous Cultural Safety Evaluation Checklist was shared with public health managers to use during regularly scheduled staff performance evaluations. The pilot of the checklist is in the preliminary stage and data is unavailable about effectiveness and use.ConclusionsAccountability tools are important to sustain the long-term effects of cultural safety education and prioritize the wellbeing of Indigenous communities. Our experience can provide guidance to health professionals in creating and measuring the efficacy of Indigenous cultural safety education to foster an anti-racist work culture as well as improved health outcomes among Indigenous communities.
Development of prognostic index based on necroptosis-related genes in patient with hepatocellular carcinoma
Authors: Hua Xiangfan , Sun Junjun , Liu Weifeng , Yang Yanhui 
Published: November 2022

Abstract
Development of prognostic index based on necroptosis-related genes in patient with hepatocellular carcinoma. Methods By analyzing the expression levels of 159 NRGs from The Cancer Genome Atlas (TCGA) database,36 differentially expressed NRGs were screened.Gene Ontology (GO) enrichment and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed to evaluate the underlying molecular mechanisms of differentially expressed NRGs in HCC.[1]The STRING online tool was used to establish a PPI network to evaluate the interactions among NRG-coded proteins. Results were observed using the Cytoscape software.The prognostic value of NRGs was established using COX regression, and a prognostic risk model for scoring patients was subsequently developed. Kaplan-Meier (KM) curves and receiver operating characteristic (ROC) curves were plotted to determine the prognostic value of the model. Finally, the performance of the model was successfully validated with the Gene Expression Omnibus (GEO) sub-dataset.
Result Compared with normal tissues,34 highly upregulated and 2 downregulated NRGs in HCC tissues were screened.GO analysis results revealed that these 36 genes are indeed related to necroptosis the function. KEGG analysis revealed that these 36 genes were correlated with Necroptosis,NLRs,Shigellosis,MAPK,andTNF signaling pathways.COX regression showed that these 4 NRGs (HSP90AA1, PPIA, SQSTM1, USP21) were associated with prognosis and developed a model.According to the high and low risk score, the patients were divided into high-risk groups and low-risk groups.The risk model had a better clinical potency than the other clinical characteristics, with the area under the ROC curve (AUC =0.806).
Conclusion Based on the differential expression of NRGs, we established a novel risk model for predicting HCC prognosis.It also provides a new basis for the study of necroptosis in hepatocellular carcinoma.
BMAL1 involved in autophagy and injury of thoracic aortic endothelial cells of rats induced by intermittent heat stress through AMPK/mTOR/ULK1 pathway
Authors: Yang Chunli , Deng Ziwei , Zeng Qihang , Chang Xiaoyu , Wu Xiaomin , Li Guanghua 
Published: November 2022

Abstract
Background
The physiological activities of the body have obvious biological rhythm. As the core of circadian rhythm, BMAL1 is the only clock gene whose deletion can lead to abnormal physiological function. However, it has not been reported whether heat exposure at different time can affect cardiovascular function changes by changing the circadian rhythm of clock genes. This study aimed to investigate whether autophagy is mediated by AMPK/mTOR/ULK1 pathway under intermittent heat exposure, and the effect of BMAL1 expression on thoracic aortic autophagy and apoptosis.
Methods
Intermittent heat stress model was established in vitro and vivo, western blot and immunofluorescence were used to detect the expressions of autophagy, apoptosis, AMPK/mTOR/ULK1 pathway and BMAL1. And then Autophagy was inhibited and activated, western blot and immunofluorescence detected the changes of autophagy and apoptosis. Finally, BMAL1 was silenced, RT-qPCR detected the expression of autophagy and apoptosis.
Results
Our study suggested heat stress induced autophagy and apoptosis were in RTAECs. In addition, intermittent heat stress raised AMPK and ULK1 but reduced the phosphorylation of mTOR in RTAECs, and autophagy inhibition by compound C reversed the expression of phosphorylation AMPK, mTOR and ULK1, the expression of Beclin1 and LC3-II/LC3-I decreased compared to the group of intermittent heat stress in vitro. Furthermore, Rapamycin mediated autophagy promoted apoptotic effects, and autophagy inhibitor 3-Methyladenine (3-MA) depressed the expression of apoptosis in vitro. After administration of Rapamycin, LC3-II/LC3-I, Beclin1 and Bax were further upregulated, whereas 3-MA alleviated the cells death. Finally, BMAL1 was elevated in vitro and vivo, and shBMAL1 reduced the expression of autophagy and apoptosis.
Conclusion
We revealed that intermittent heat stress induced apoptosis and autophagy. BMAL1 may involve in the occurrence of autophagy and apoptosis by AMPK/mTOR/ULK1 pathway.
A Gene Pathway Enrichment Method Based on Improved TF-IDF Algorithm
Authors: Xu Shutan , Leng Yinhui , Feng Guofu , Zhang Chenjing , Chen Ming 
Published: November 2022

Abstract
Gene pathway enrichment analysis is a widely used method to analyze whether a gene set is statistically enriched on certain biological pathway network. Current gene pathway enrichment methods commonly consider local importance of genes in pathways without considering the interactions between genes. In this paper, we propose a gene pathway enrichment method (GIGSEA) based on improved TF-IDF algorithm. This method employs gene interaction data to calculate the influence of genes based on the local importance in a pathway as well as the global specificity. Computational experiment result shows that, compared with traditional gene set enrichment analysis method, our proposed method in this paper can find more specific enriched pathways related to phenotype with higher efficiency.
Reversing increased neuronal nitric oxide synthase in Alzheimer’s disease prevents aberrant glutamatergic calcium responses
Authors: Balez Rachelle , Stevens Claire H. , Lenk Kerstin , Maksour Simon , Sidhu Kuldip , Sutherland Greg , ooi lezanne 
Published: November 2022

Abstract
Background
Nitrosative stress is a feature of Alzheimer’s disease, however the underlying mechanisms driving nitrosative stress and the impact of nitric oxide on neuronal function in Alzheimer’s disease is still largely unknown.
Methods
We analysed neuronal nitric oxide synthase (nNOS) protein levels in post mortem tissue and induced pluripotent stem cell (iPSC) derived neurons from Alzheimer’s patients and controls by immunohistochemistry and western blots. Furthermore, we assessed the impact of modulating nNOS function or nitric oxide levels on neuronal glutamatergic signalling using calcium imaging.
Results
We show that nNOS protein levels are increased in early and severely affected brain regions of late-onset Alzheimer’s disease post mortem tissue, but not late and mildly affected regions, or cognitively normal individuals. The increased nNOS phenotype was also present in iPSC-derived neurons from Alzheimer’s disease patients compared to controls, along with increased levels of nitrite, a stable marker of nitric oxide. We observed a divergent functional impact of nitric oxide that included strengthening the calcium response in control neurons, while dysregulating calcium signaling and altering the amplitude and kinetics of the calcium responses to glutamate in the Alzheimer’s disease neurons. Pharmacological modulation of nitric oxide levels or production prevented aberrant calcium signaling in Alzheimer’s disease neurons.
Conclusions
Together these data identify increases in nNOS protein in Alzheimer’s disease. Functional data suggest nitric oxide modulation of glutamatergic calcium signaling is neuroprotective under non-pathogenic conditions, with increased nNOS and nitric oxide contributing to pathogenic signaling changes during Alzheimer’s disease.
Preoperative gadoxetic acid-enhanced MRI combined with microvascular invasion can effectively improve the predictive efficacy of early recurrence in hepatocellular carcinoma : a Two- center Study
Authors: Zhang Jiyun , Lu Xinyu , Zhang Tao , Zhang Xueqin 
Published: November 2022

Abstract
Objectives
To compare the effective of preoperative factors based on gadoxetic acid-enhanced magnetic resonance imaging (MRI) and pre-/postoperative factors in predicting early recurrence of hepatitis B virus(HBV)-related single hepatocellular carcinoma (HCC) after surgical resection.
Methods
This is a retrospective two-center study, from July 2013 to November 2018 consecutive patients underwent surgery for HCC with preoperative gadoxetate disodium (EOB)-enhanced MR were enrolled, to training and testing sets. In the training sets, multivariate Cox regression analyses of preoperative and postoperative high risk predictors of early HCC recurrence (EHR) were performed. Preoperative and pre-/postoperative prediction models were constructed. In the training sets and testing sets, using the time-dependent receiver operating characteristic(ROC) curves to evaluate the discrimination of the two prediction models, area under curves (AUC) were calculated. The diagnostic performance of each risk features and combine features were also calculated. Recurrence-free survival (RFS) were analysed by the Kaplan–Meier method with the log-rank test.
Results
Three MRI features were independently associated with EHR: (nonhypervascular hepatobiliary phase(HBP) hypointense nodule (NHHN) (Hazard Ratio(HR) = 3.700), non-smooth tumour margin (HR = 2.781), and hepatobiliary phase (HBP) peritumoural hypointensity (HR = 2.614). After adding postoperative histopathologic factors, presence of microvascular invasion (MVI) and one MRI features were independently associated with EHR: MVI (HR = 3.885), NHHN (HR = 4.320). In the training sets, AUCs for the two models were 0.821 (preoperative prediction models), 0.890 (pre-/postoperative prediction models). In the testing sets, AUCs for the two models were 0.748 (preoperative prediction models), 0.794 (pre-/postoperative prediction models). The diagnostic performance of each risk factor and combine factors were all lower than the two prediction models.
Conclusions
In this two-center study, the preoperative and pre-/postoperative prediction models demonstrate good performance for predicting EHR, the AUC of the two prediction model better than only the MVI risk factor. In the preoperative prediction model, NHHN, non-smooth tumour margin, and HBP peritumoural hypointensity can be used preoperatively to estimate the risk of early recurrence after resection of a single HCC. Such models might be useful to guide treatment strategies and enable a step forward for precise medicine.