bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic performance and neural basis of the combination of free‐ and pre‐drawn Clock Drawing Test
Authors: Imai Ayu , Matsuoka Teruyuki , Kato Yuka , Narumoto Jin 
Published: March 2022

AbstractObjectivesThis study aimed to clarify the diagnostic performance and neural basis of the Clock Drawing Test (CDT) combining free‐ and pre‐drawn methods.MethodsThis retrospective study included 165 participants (91 with Alzheimer disease [AD], 52 with amnestic mild cognitive impairment [aMCI], and 22 healthy controls [HC]), who were divided into four groups according to their free‐ and pre‐drawn CDT scores: group 1, could do both; group 2, impaired in both; group 3, impaired in pre‐drawn CDT; and group 4, impaired in free‐drawn CDT. The diagnostic performances of the free‐drawn, pre‐drawn, and combination methods were compared using receiver operating characteristics analysis; in voxel‐based morphometry analysis, the gray matter (GM) volume of groups 2–4 were compared with that of group 1.ResultsThe area under the curve of the combination method was greater than that of the free‐ or pre‐drawn method alone when comparing AD with HC or aMCI. Group 2 had a significantly smaller GM volume in the bilateral temporal lobes than group 1. Group 3 had a trend toward smaller GM volumes in the right temporal lobe when a liberal threshold was applied. Group 4 had significantly smaller GM volumes in the left temporal lobe than group 1.ConclusionsThis study suggests that the combination method may be able to screen for a wider range of brain dysfunction. Combined use of free‐ and pre‐drawn CDT may be useful for screening for AD and its early detection and treatment.
Temporal pole volume is associated with episodic autobiographical memory in healthy older adults
Authors: Setton Roni , Sheldon Signy , Turner Gary R. , Spreng R. Nathan 
Published: March 2022

AbstractRecollection of personal past events differs across the lifespan. Older individuals recall fewer episodic details and convey more semantic information than young. Here we examine how gray matter volumes in temporal lobe regions integral to episodic and semantic memory (hippocampus and temporal poles, respectively) are related to age differences in autobiographical recollection. Gray matter volumes were obtained in healthy young (n = 158) and old (n = 105) adults. The temporal pole was demarcated and hippocampus segmented into anterior and posterior regions to test for volume differences between age groups. The Autobiographical Interview was administered to measure episodic and semantic autobiographical memory. Volume associations with episodic and semantic autobiographical memory were then assessed. Brain volumes were smaller for older adults in the posterior hippocampus. Autobiographical memory was less episodic and more semanticized for older versus younger adults. Older adults also showed positive associations between temporal pole volumes and episodic autobiographical recall; in the young, temporal pole volume was positively associated with performance on standard laboratory measures of semantic memory. Exploratory analyses revealed that age‐related episodic autobiographical memory associations with anterior hippocampal volumes depended on sex. These findings suggest that age differences in brain structures implicated in episodic and semantic memory may portend reorganization of neural circuits to support autobiographical memory in later life.
Use of BTK inhibitors with focus on ibrutinib in mantle cell lymphoma: An expert panel opinion statement
Authors: Zinzani Pier Luigi , Martelli Maurizio , Ferrero S. , Gentile Massimo , Laurenti Luca , Romana Mauro Francesca , Sportoletti Paolo , Tedeschi Alessandra , Varettoni M. , Visco Carlo 
Published: March 2022

AbstractThe introduction of Bruton's tyrosine kinase (BTK) inhibitors transformed the management of patients with mantle cell lymphoma (MCL). Ibrutinib, the first‐in‐class BTK inhibitor is now approved in more than 80 countries and there are over 20 new BTK inhibitors in development. In addition, novel agents show potential clinical activity (alone and in combination) and are in the approval phase and/or being studied in ongoing clinical trials. How does the practicing clinician decide on the optimal therapeutic strategy for this highly heterogenous disease? In July 2020 a group of experts from Italy, convened a meeting to address and provide clarification on a series of outstanding issues in the treatment of MCL with the view of providing clinical guidance on its management. This expert opinion statement represents the panel's collective analysis, evaluation, and recommendations and is made up of a series of questions and answers (in the form of a review of the pertinent literature) designed to replicate those posed by practicing clinicians in Italy but which are applicable to clinical settings worldwide.
Ultra‐robust stretchable electrode for e‐skin: In situ assembly using a nanofiber scaffold and liquid metal to mimic water‐to‐net interaction
Authors: Cao Jinwei , Liang Fei , Li Huayang , Li Xin , Fan Youjun , Hu Chao , Yu Jing , Xu Jin , Yin Yiming , Li Fali , Xu Dan , Feng Hanfang , Yang Huali , Liu Yiwei , Chen Xiaodong , Zhu Guang , Li Run‐Wei 
Published: March 2022

AbstractThe development of stretchable electronics could enhance novel interface structures to solve the stretchability–conductivity dilemma, which remains a major challenge. Herein, we report a nano‐liquid metal (LM)‐based highly robust stretchable electrode (NHSE) with a self‐adaptable interface that mimics water‐to‐net interaction. Based on the in situ assembly of electrospun elastic nanofiber scaffolds and electrosprayed LM nanoparticles, the NHSE exhibits an extremely low sheet resistance of 52 mΩ sq−1. It is not only insensitive to a large degree of mechanical stretching (i.e., 350% electrical resistance change upon 570% elongation) but also immune to cyclic deformation (i.e., 5% electrical resistance increases after 330 000 stretching cycles with 100% elongation). These key properties are far superior to those of the state‐of‐the‐art reports. Its robustness and stability are verified under diverse circumstances, including long‐term exposure to air (420 days), cyclic submersion (30 000 times), and resilience against mechanical damages. The combination of conductivity, stretchability, and durability makes the NHSE a promising conductor/electrode solution for flexible/stretchable electronics for applications such as wearable on‐body physiological signal detection, human–machine interaction, and heating e‐skin.
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Agricultural water management practices to improve the climate resilience of irrigated agriculture in India
Authors: Sikka Alok K. , Alam Mohammad Faiz , Mandave Vidya 
Published: March 2022

AbstractThe projected implications of climate change for water and agriculture to meet diverse and competitive water demands requires smart water management solutions. Science‐ and evidence‐based, agricultural water management (AWM) can significantly contribute to reduce unsustainable water use and help enhance water resilience and adaptation to climate change. This paper presents a brief overview of potential AWM practices focusing on enhancing water resilience, increasing yields, and wherever possible, reducing emissions. This is achieved via increased land and water use efficiency, water and energy savings, and improved water productivity with considerable scope to improve agricultural resilience. In this context, the prioritization of a location‐specific portfolio of smart AWM practices to make the right investment decisions is very important. We present two distinct and complementary approaches to prioritize AWM practices in this paper: one follows stakeholder analysis to build a prioritized portfolio of climate‐smart AWM practices and the other employs a simple water balance‐based approach to prioritize interventions. The way forward in mainstreaming and scaling out context‐specific climate‐smart AWM interventions is also discussed with a focus on capacity building, water management extension services, and the mobilization of resources through the convergence of institutions and co‐financing from relevant development schemes.
Evaluation of gravity‐led and energy‐fed drainage for sustaining food security in the polders of the coastal zone of Bangladesh
Authors: Mondal Manoranjan K. , Yadav Sudhir , Baidya Bishwajit , Khan Zahirul H. , Sutradhar Asish , Humphreys Elizabeth , Kamal Farhana A. , Jagadish S. V. Krishna 
Published: March 2022

AbstractBangladesh is currently self‐sufficient in rice production but faces immense challenges of sustaining that self‐sufficiency because of population growth and climate change. There is little scope to further increase cropping intensity except in the underutilized 1.2 Mha of lands enclosed in the polders of the coastal zone. The main impediment to wide‐scale adoption of more productive cropping systems in the polders is poor drainage that often results in waterlogging. Therefore, a study was conducted in polder 30, in the medium‐salinity region of the south‐west coastal zone, to examine the biophysical and economic feasibility of low‐cost gravity (gravity‐led) drainage. The results show a considerable opportunity to increase rice production in the polders with improved drainage practices. The feasibility of drainage through pumping (energy‐fed) was also assessed, given that there are already situations where gravity‐led drainage is not feasible, and these situations are likely to increase because of climate change‐induced sea level rise and the sinking of polder lands. Energy‐fed drainage was demonstrated to be profitable with a yield gain of at least 1.5 t/ha from just the wet season; further intensification to 50% of polder lands may yield an additional harvest of 3–6 million tons of rice per year. Therefore, investing in improved drainage management in the polders could be a major game changer in sustaining the food security of the nation, especially the climate‐vulnerable polder communities of Bangladesh.
A mindfulness‐based well‐being group for international students in higher education: A pilot study
Authors: Xiong Yiying , Prasath Priscilla Rose , Zhang Qiyang , Jeon Lieny 
Published: March 2022

AbstractWith an increasing number of international students enrolled in U.S. higher education, they were reported to have severe mental health issues, especially during the coronavirus disease (COVID‐19) pandemic. It is critical to provide evidence‐based mental health services to help them cope with those issues and promote mental health and the overall well‐being of international students. In this article, we utilized a randomized controlled trial to pilot‐test the effectiveness of a mindfulness‐based well‐being group for international students (MBWIS) in improving participants’ overall well‐being and mental health. The results indicated that the MBWIS not only improves international students’ trait mindfulness but also increases positive mental health as well as decreases their overall psychological distress and perceived discrimination. Related findings and implications for counselors and university personnel, including how to implement MBWIS in mental health facilities, are discussed within the existing literature.
Anger rumination and imagined violence as related to violent behavior before and after psychiatric hospitalization
Authors: Hardin Kaitlin M. , Contreras Isaias M. , Kosiak Klaudia , Novaco Raymond W. 
Published: March 2022

AbstractObjectiveAnger rumination and imagined violence, in the context of anger/aggression proclivity, are examined for their direct and conjoint associations with violent behavior by psychiatric patients.MethodA secondary analysis of data from the MacArthur Violence Risk Study was conducted with 1136 acute civil commitment patients, assessed during hospitalization and after hospital discharge. Anger/aggression proclivity was assessed with the Brief Psychiatric Rating Scale hostility subscale, anger rumination was indexed using items from the Novaco Anger Scale, and imagined violence was measured with Grisso's Schedule of Imagined Violence. Violence, prehospitalization and posthospitalization, was indexed by the MacArthur project measure.ResultsCorrelational analyses, mediation analyses, and moderated mediation analyses were conducted. Anger rumination significantly predicted pre‐ and posthospitalization violence, when controlling for age, sex, race, childhood physical abuse, and anger/aggression proclivity; and it partially mediated the relation between anger/aggression proclivity and violence. Imagined violence and anger rumination were highly inter‐related. When imagined violence was added to the regression model, it was a significant predictor of prehospitalization violence; however, it did not moderate the association of anger rumination with pre‐ or posthospitalization violence.ConclusionAnger rumination may be a mechanism through which anger activates violent behavior, which has important implications for psychotherapeutic intervention targeting. Future research should investigate the association between anger rumination and imagined violence, with attention given to revenge planning as a link.
Cognitive and emotional factors associated with the desire to cease non‐suicidal self‐injury
Authors: Gray Nicole , Hasking Penelope , Boyes Mark 
Published: March 2022

AbstractBackgroundDue to cognitive and emotional differences between individuals who have and have not stopped self‐injuring, we explored these in the context of desire to stop.MethodAustralian university students (n = 374) completed cognitive and emotional measures. Comparisons were made between those who had self‐injured in the past 12 months and those who had not, and between individuals who reported wanting to stop self‐injuring and those who did not.ResultsApproximately 20% of participants did not want to stop self‐injuring. Cognitive emotional factors (psychological distress, self‐efficacy to resist, difficulties regulating emotion, interpersonal functions, and outcome expectancies) differentiated individuals who had and had not stopped, but could not explain differences in desire to stop.ConclusionFactors associated with desire to stop are not the same as factors underlying behavioural cessation. Motivational approaches to changes in self‐injurious behaviour would be beneficial for clinicians and their clients.
Effect of Mild and Moderate Hepatic Impairment (Defined by Child–Pugh Classification and National Cancer Institute Organ Dysfunction Working Group Criteria) on Pexidartinib Pharmacokinetics
Authors: Zahir Hamim , Greenberg Jonathan , Hsu Ching , Marbury Thomas C. , Lasseter Kenneth C. , Xu Li‐An , Tap William D. , Healey John H. , Stacchiotti Silvia , LaCreta Frank 
Published: March 2022

AbstractPexidartinib is a novel oral small‐molecule tyrosine kinase inhibitor targeting the colony‐stimulating factor 1 receptor. Pexidartinib undergoes extensive hepatic metabolism via multiple cytochrome P450 and uridine 5'‐diphospho‐glucuronosyl transferase enzymes, with ZAAD‐1006a as the only major metabolite in human plasma. As pexidartinib is extensively metabolized, hepatic impairment (HI) could lead to increased exposure to pexidartinib. The objective of the two phase 1, open‐label studies was to determine the pharmacokinetics of pexidartinib after a single 200‐mg dose in subjects with mild and moderate HI, based on Child–Pugh classification (PL3397‐A‐U123: 8 mild HI and 8 moderate HI vs 16 matched healthy controls) and National Cancer Institute Organ Dysfunction Working Group (NCI‐ODWG) criteria (PL3397‐A‐U129: 8 moderate HI versus 8 matched healthy controls [NCT04223635]). Based on Child–Pugh classification, exposure to pexidartinib (maximum observed concentration [Cmax], area under the plasma concentration–time curve up to the last measurable concentration [AUClast], and extrapolated to infinity [AUCinf]) was similar in subjects with mild and moderate HI and in respective matched healthy controls, whereas ZAAD‐1006a exposure (AUC) was approximately 27% to 28% and 41% to 48% higher in mild and moderate HI, respectively. According to NCI‐ODWG criteria, total pexidartinib exposure was 42% to 46% higher in subjects with moderate HI, compared with healthy controls, and total ZAAD‐1006a exposure was 70% to 79% higher for subjects with moderate HI, compared with matched healthy controls with normal hepatic function. These findings were used to develop appropriate dose recommendations in patients with hepatic impairment.
Utility of renal scintigraphy in diagnosis of multicystic dysplastic kidney
Authors: Hannallah Arthi , Baker Zoë G. , De Filippo Roger E. , Sparks S. Scott , Ko Joan , Vasquez Evalynn 
Published: March 2022

AbstractPurposeTo compare the prevalence of vesicoureteral reflux (VUR), febrile urinary tract infection (fUTI), and chronic kidney disease (CKD) among patients with multicystic dysplastic kidney (MCDK) diagnosed by renal scintigraphy (RS) versus follow‐up renal ultrasound (RUS) alone.MethodsThis was a retrospective review of patients seen at a tertiary care center from 2010 to 2020 with MCDK diagnosed by RS or follow‐up RUS. Differences in the prevalence of VUR, fUTI, and CKD by cohort were assessed using logistic regression analysis, Pearson X2, and Fisher's Exact tests. Temporal trends in diagnostic methods used (RUS versus RUS + RS) were evaluated using the Cochran‐Armitage trend test.ResultsOne‐hundred seventy‐two patients were included: 50% (n = 86) underwent RUS + RS and 50% (n = 86) underwent RUS alone to diagnose MCDK. Prevalence of VUR, fUTI, and CKD did not significantly vary between groups. Among patients who had a VCUG, 4.4% had contralateral VUR (1.7% RUS + RS group; 7.4% RUS group; p = 0.19) and 14.5% had at least one fUTI (16.3% RUS + RS group; 12.8% RUS group; p = 0.52). Females were significantly more likely to have at least one fUTI (p = 0.04). Four patients (2.3%) developed CKD, all in the RUS + RS cohort (p = 0.12). Diagnosis of MCDK by RUS versus RUS + RS did not significantly vary over time (p = 0.17).ConclusionPatients with unilateral MCDK confirmed by RS versus RUS alone do not significantly vary in the prevalence of VUR, fUTI, or CKD. Renal scintigraphy studies may not be necessary in unilateral MCDK diagnosis but continue to be used.
Social information use in adolescents with conduct problems and varying levels of callous‐unemotional traits
Authors: Gaule Anne , Bevilacqua Leonardo , Molleman Lucas , Roberts Ruth , Duijvenvoorde Anna C. van , den Bos Wouter van , McCrory Eamon J. , Viding Essi 
Published: March 2022

AbstractBackgroundAdolescents with conduct problems (CP) are characterised by difficulties with social relationships and display atypical social cognition, such as when interpreting emotional expressions or engaging in social problem‐solving. One important aspect of social cognition that warrants investigation is the degree to which these adolescents factor others' views into their already held beliefs, and strategies used to do so. Effective social information use enables attunement to social environment, cooperation, and social problem‐solving. Difficulties in this regard could contribute to problems in social interactions in adolescents with CP, and may vary with adolescents' high (CP/HCU) versus low levels of callous‐unemotional traits (CP/LCU).MethodsWe compared social information use in boys (11–16 years) with CP/HCU (n = 32), CP/LCU (n = 31) and typically developing (TD) peers (n = 45), matched for IQ. Participants provided estimates of numbers of animals on a screen, saw another adolescent's estimate, and could adjust their initial estimate. We compared two aspects of social information use: (1) degree of adjustment of initial estimate towards another's estimate and (2) strategy use when adjusting estimates.ResultsDegree of adjustment towards another's estimate did not vary across groups, but strategy use did. Adolescents with CP/LCU compromised less following social information than TD peers.ConclusionsFindings suggest that while adolescents with CP are able to take social information into account, those with CP/LCU use this information in a way that differs from other groups and could be less efficient. This warrants further systematic investigation as it could represent a target for behaviour management strategies. Overall, this study highlights the need for more research delineating the social‐cognitive profile of adolescents with CP/LCU.
Pollen morphology of selected melliferous plants and its taxonomic implications using microscopy
Authors: Attique Rafia , Zafar Muhammad , Ahmad Mushtaq , Zafar Sadia , Ghufran Muhammad Asad , Mustafa Muhammad Raza Ul , Yaseen Ghulam , Ahmad Latif , Sultana Shazia , Nabila  , Zafar Aqeela , Majeed Salman 
Published: March 2022

AbstractThis research aimed to explore the melliferous bee flora pollen from arid zones of District Attock, Islamabad Capital and Rawalpindi. Morpho‐palynological features has provided key information for the classification and help to explain the taxonomy of several genera and species. Therefore, in this work, we examined the morphological characters of pollen potentially to be used for the species delimitation of bee flora. A total of 18 bee floral species, classified into 12 different families were collected, pressed, identified and then acetolyized to observe the grains under microscopy. Bee pollen can be described by small, medium to large sized morphotypes presenting five types of shapes, prolate spheroidal in (seven species), sub‐prolate (six species), oblate spheroidal (three species), oblate and prolate (one species each) was examined. The observed polar and equatorial diameter were found maximum in Zea mays 73.5 μm and Pelargonium inquinans 66.75 μm respectively. Pollen of six different types was found namely: tricolporate, 3‐zonocolporate, monoportae, tetracolporate, tetraporate and mononsulcate. Whereas highest value of colpi length was measured in Grewia tenax (24.55 μm). Exine surface nature of pollen was examined echinate psilate and scabrate. Exine thickness noted to be maximum in Verbena tenuisecta (8.40 μm) and minimum in Citrus macrocarpa (0.4 μm). Bee floral species considered difficult to identify based on other morphological traits were successfully distinguished using pollen quantitative and qualitative traits, confirming the importance of pollen morphology to diagnose characters to correctly identify honeybee flora.Research Highlights
Pollen diversity among honeybee flora.
Highly variations observed via microscopy in pollen micromorphology.
Palyno‐morph has taxonomic value for the identification of honeybee floral species.
Rapid inactivation of Dabie bandavirus (SFTSV) by irradiation with deep‐ultraviolet light‐emitting diode
Authors: Kaneko Chiho , Saito Akatsuki , Inagaki Hiroko , Sugiyama Hironobu , Mazimpaka Eugene , Fujimoto Shouichi , Okabayashi Tamaki 
Published: March 2022

AbstractSevere fever with thrombocytopenia syndrome (SFTS) caused by Dabie bandavirus (SFTSV) is a serious public health concern in endemic areas, particularly in Asian and Southeast Asian countries. SFTSV is transmitted by direct contact with body fluids from infected humans and animals. Therefore, environmental hygiene in hospitals and veterinary clinics in SFTSV‐endemic areas is highly important. This study assessed the effects of continuous and intermittent irradiation with deep‐ultraviolet light‐emitting diode (DUV‐LED) on SFTSV. Evaluation was performed by conducting plaque assay in which SFTSV irradiated with deep‐ultraviolet (DUV; 280 ± 5 nm) was inoculated onto Vero cells. The results showed that continuous and intermittent irradiation for 5 s, resulting in 18.75 mJ/cm2 of cumulative UV exposure, led to a >2.7 and >2.9 log reduction, respectively, corresponding to a >99.8% reduction in infectivity. These results demonstrate that DUV can be utilized for inactivation of SFTSV to maintain environmental hygiene in hospitals and veterinary clinics in endemic countries.