bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quadriceps tendon autograft with or without bone block have comparable clinical outcomes, complications and revision rate for ACL reconstruction: a systematic review
Authors: Meena Amit , D’Ambrosi Riccardo , Runer Armin , Raj Akshya , Attri Manish , Abermann Elisabeth , Hoser Christian , Fink Christian 
Published: December 2022

AbstractPurposeThe purpose of this systematic review is to report complications, graft failure, fixation methods, rehabilitation protocol, clinical and patient-reported outcomes, and return to sports with the use of quadriceps tendon graft with the bone block (QT-B) and without bone block (QT-S).MethodsAccording to the PRISMA guidelines a comprehensive search was performed across PubMed/MEDLINE, Scopus, EMBASE, and Cochrane Library databases from inception until April 2022. Only prospective studies using quadriceps tendon autograft with a minimum of 20 patients were considered for inclusion. The outcome measures extracted from the studies were the KT-1000, Lysholm score, Subjective and Objective IKDC, Tegner, Marx Score, complications, failures and/or revision surgery, and rate of return to sports. Cochrane risk of bias and MINORS tool were used for the risk of bias assessment of all included studies.ResultsA total of 13 studies were included, consisting of 5 randomized controlled trials, 6 cohort studies, 1 case–control and 1 case series. A total of 484 patients received QT-S in 6 studies of which 224 (46.2%) were males and 212 (43.8%) females with a mean age of 21.5 ± 7.5 (range 14–58). While 243 patients received QT-B in 7 studies of which 167 (68.7%) were males and 76 (31.3%) females with a mean age of 28.9 ± 4.5 (range: 18–49). The studies analyzed had a mean MINORS score of 14.6 (range, 12–19). Both QT-B and QT-S for ACL reconstruction reported satisfactory results in terms of patient-reported outcome measures. Although, a slightly higher anterior laxity was found with the QT-S than with the QT-B.ConclusionQuadriceps tendon with a bone block (QT-B) or without bone block (QT-S) for ACL reconstruction is supported by current literature. Both grafts are safe and viable options for ACL reconstruction with comparable clinical outcomes, complications and revision rates.Level of evidenceLevel IV.RegistrationPROSPERO-CRD42022347134;https://www.crd.york.ac.uk/prospero/
Comparing the Efficacy of Multiple Drugs Injection for the Treatment of Hypertrophic Scars and Keloid: A Network Meta-Analysis
Authors: Wu Wenhao , Zhao Yang , Chen Yuxuan , Zhong Aimei 
Published: December 2022

Abstract
Background
There is no consensus regarding the choice of injected drugs for pathological scars. Although the clinical efficacy of different drug treatments was shown in many randomized controlled trials, the efficacies of many drugs are inconsistent. Therefore, this study aimed to determine how different effective drugs are for treating pathological scars. It is anticipated that the study findings may serve as guidelines for plastic surgeons.

Methods
Relevant literature was extracted from the following databases Cochrane Library, Embase, PubMed, Web of Science, CNKI, Weipu, and Wanfang until June 2022, such as randomized clinical trials (RCTs) evaluating different injected drugs for the treatment of pathological scars, including BTA, TAC, 5-Fu, VER, and BLE.

Results
This network meta-analysis of 1539 patients from 23 articles revealed that the most effective treatment for a pathological scar was TAC + BTA. The effective rate of TAC + BTA combination therapy was significantly different from that of the BTA, TAC, 5-Fu, VER, and BLM monotherapies. TAC+5-FU was more effective than TAC, 5-FU, VER, or BLM alone, and BTA was more effective than both TAC and 5-Fu. The effectiveness of VER and BLM was the same, but both were better than TAC and 5-Fu. No big differences were found between any of the other local injection therapies.

Conclusions
According to this network meta-analysis, a combination of keloid and hypertrophic scar injection treatment is recommended, especially BTA+TAC. However, this network meta-analysis has some limitations and must be further verified by larger samples and higher quality RCTs.

Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266
Five Year Analyses of Vegetation Response to Restoration using Rock Detention Structures in Southeastern Arizona, United States
Authors: Wilson Natalie R. , Norman Laura M. 
Published: December 2022

AbstractRock detention structures (RDS) are used in restoration of riparian areas around the world. The purpose of this study was to analyze the effect of RDS installation on vegetation in terms of species abundance and composition. We present the results from 5 years of annual vegetation sampling which focused on short term non-woody vegetation response within the riparian channel at 3 restoration sites across southeastern Arizona. We examined the potential ways that RDS can preserve native species, encourage wetland species, and/or introduce nonnative species using a Control-Impact-Paired-Series study design. Species composition and frequency were measured within quadrats and zones on an annual basis. Multivariate bootstrap analyses were performed, including Bray-Curtis dissimilarity index and non-metric multidimensional scaling ordination. We found that response to RDS was variable and could be related to the level of degradation or proximity to groundwater. The non-degraded site did not show a response to RDS and the severely degraded site showed a slight increase in vegetation frequency, but the moderately degraded site experienced a significant increase. At the moderately degraded site, located between two historic ciénegas (desert wetlands), species composition shifted and nonnative species invaded, dominating the vegetation increase at this location. At the severely degraded site, pre-existing wetland species frequency increased in response to the installation of RDS. These findings extend the understanding of RDS effects on vegetation, provide scenarios to help land and water resource managers understand potential outcomes, and can assist in optimizing success for restoration projects.
Preperitoneal Packing for Pelvic Fracture Bleeding Control: A Human Cadaver Study
Authors: Benjamin Elizabeth R. , Warriner Zachary , Demetriades Demetrios 
Published: December 2022

AbstractBackgroundPreperitoneal packing (PPP) has been widely accepted as a damage control technique for severe bleeding from pelvic fractures. It is supposed to work by direct compression and tamponade of the bleeding source in the pelvis and it has been suggested to be effective for both venous and arterial bleeding. However, there is little evidence to support its efficacy or the ability to place the laparotomy pads in proximity of the desired location.MethodsBilateral PPP was performed on 10 fresh human cadavers, followed by laparotomy and measurements of resultant pad placement in relation to critical anatomic structures.ResultsA total of 20 assessments of laparotomy pad placement were performed. Following completion of PPP, a midline laparotomy was performed to determine proximity and closest distance of the laparotomy pads to sites of potential bleeding in pelvic fractures. In almost all cases, the pad placement was not contiguous with the key anatomic structure with mean placement 3.9 + 1.1 cm from the sacroiliac joint, 3.5 + 1.6 cm from the common iliac artery, 1.1 + 1.2 cm from the external iliac artery, 2.8 + 0.8 cm from the internal iliac artery, and 2.3 + 1.2 cm from the iliac bifurcation. Surgeon experience resulted in improved placement relative to the sacroiliac joint, however the pads still did not directly contact the target point.ConclusionThis human cadaver study has shown that PPP, even in experienced hands, may not be placed in significant proximity of anatomical structures of interest. The role of PPP needs to be revisited with better clinical or human cadaver studies.
Wahrnehmung von Körpergewicht in der Behandlung von Anorexia nervosa
Authors: Behrens Simone C. , Ziser Katrin , Mack Isabelle , Giel Katrin 
Published: December 2022

Zusammenfassung
Hintergrund
Die Gewichtszunahme im Rahmen der stationären Behandlung von Anorexia nervosa führt typischerweise zu einer Aktualisierung von zwei Kernsymptomen: Angst vor Gewichtszunahme und hohem Stellenwert eines niedrig gewichtigen Körpers für den Selbstwert.

Ziel der Arbeit
Um den Nutzen einer biometrischen Figure-rating-Skala (FRS) für das Monitoring der Angst vor einer Gewichtszunahme und dem Körperbild während einer stationären Behandlung von Anorexia nervosa abschätzen zu können, wurden in einer Fallserie explorativ dynamische Entwicklungen in aktuell empfundenem und idealem Körpergewicht untersucht.

Material und Methoden
Es wird eine auf Unter- bis Normalgewicht optimierte biometrische FRS eingesetzt. Auf dieser Skala markierten 13 stationär behandelte Patientinnen mit der Diagnose einer typischen Anorexia nervosa wöchentlich nach dem Wiegetermin die beiden Körper, die dem aktuellen und dem idealen Körper der Patientinnen am ehesten entsprechen. Die Angaben wurden mit dem Gewichtsverlauf verglichen.

Ergebnisse
Insgesamt wurden 128 Wiegetermine ausgewertet. Es zeigten sich differenzierte, im Verlauf variierende Antworten, die drei typische Muster aufwiesen: (1) konstante Unzufriedenheit mit dem Körpergewicht und akkurate Einschätzung bei wenig Gewichtsveränderung, (2) konstante Unzufriedenheit mit dem Körpergewicht und akkurate Einschätzung bei konstanter Zunahme, (3) wechselnde Unzufriedenheit mit dem Körpergewicht und Genauigkeit, die abhängig vom Gewichtsverlauf springen.

Diskussion
Die Beobachtungen stützen die Sinnhaftigkeit von FRS für das Monitoring von Kognitionen und Affekten im Hinblick auf das eigene Körpergewicht in der stationären Behandlung von Anorexia nervosa. Die Interpretation der Skalen sollte im Einzelfall nur unter Hinzunahme weiterer Informationen erfolgen.
Diagnostik und Therapie organischer intraorbitaler Fremdkörper
Authors: Holtmann Christoph , Roth Mathias B. , Lanzman Rotem S. , Turowski Bernd , Antoch Gerald , Mackenzie Colin R. , Borrelli Maria , Geerling Gerd 
Published: December 2022

Zusammenfassung
Hintergrund
Orbitaverletzungen mit organischen Fremdkörpern sind eine klinische Herausforderung, da sie eine Vielzahl von Komplikationen verursachen können und manchmal zu irreversiblen Visuseinschränkungen führen.

Material und Methoden
Wir berichten über 5 konsekutive Fälle von Patienten mit organischen orbitalen Fremdkörpern, die zwischen 2012 und 2022 vorstellig wurden. Alter, Geschlecht, Zeitpunkt der Verletzung, Verletzungsmechanismus, bestkorrigierter Visus prä- und postoperativ, Vorhandensein von Schmerzen, Motilitätseinschränkungen, durchgeführte Bildgebung, Therapie sowie Komplikationen wurden ausgewertet.

Ergebnisse
Das mittlere Patientenalter betrug 62 ± 33 Jahre und das Geschlechterverhältnis war 4/1 (weiblich/männlich). In 4 Fällen war von einem Verletzungsgeschehen berichtet worden, welches im Mittel 4,6 (0/14 min/max) Tage zurücklag. Der bestkorrigierte Visus bei Erstvorstellung betrug 0,5 ± 0,2 dezimal und nach einem mittleren Follow-up von 12,7 (0,5/38 min/max) Monaten 0,67 ± 0,3 dezimal (p = 0,2). Der Grund der Erstvorstellung waren Schmerzen (n = 3) und/oder Doppelbilder (n = 2). Bei allen Patienten wurde eine Computertomographie (CT) durchgeführt. In allen 5 Fällen konnte das Fremdkörpermaterial chirurgisch vollständig entfernt werden, wobei eine Patientin wegen verbliebender Fremdkörper mehrmals operiert werden musste. Beim Fremdkörpermaterial handelte sich in 4 Fällen um Holz und einmal um Wachs.

Schlussfolgerung
Bei Orbitatraumata muss eine sorgfältige Wundexploration durchgeführt werden, insbesondere wenn der Unfallhergang anamnestisch nicht eindeutig zur klären und verbleibende Fremdkörper oder eine Perforationsverletzung nicht ausgeschlossen werden können. Die Bildgebung der Wahl ist die CT, die ggf. im postoperativen Verlauf erneut durchgeführt werden muss.
Daily life and psychosocial functioning of adults with congenital heart disease: a 40–53 years after surgery follow-up study
Authors: Pelosi C. , Kauling R. M. , Cuypers J. A. A. E. , van den Bosch A. E. , Helbing W. A. , Utens E. M. W. J. , Legerstee J. S. , Roos-Hesselink J. W. 
Published: December 2022

Abstract
Introduction
Nowadays, more than 90% of patients with congenital heart disease (CHD) reach adulthood. However, knowledge about their psychosocial functioning is limited.

Methods
Longitudinal cohort study of patients (n = 204, mean age: 50 years, 46.1% female) who were operated during childhood (< 15 years) between 1968 and 1980 for one of the following diagnoses: atrial septal defect, ventricular septal defect, pulmonary stenosis, tetralogy of Fallot or transposition of the great arteries. Psychosocial functioning was measured every 10 years, using standardized and validated questionnaires. Results were compared with the general Dutch population and over time.

Results
After a median follow-up of 45 [40–53] years adults with CHD had a significantly lower educational level, occupation level and employment rate, but better health-related quality of life and emotional functioning compared with normative data. Patients with moderate/severe defects reported significantly more self-perceived physical restrictions and lack of physical strength due to their CHD. Compared to 2011, in 2021 patients considered their CHD as more severe and they felt more often disadvantaged.

Conclusions
Overall, despite a lower education, occupation level and employment rate, our sample of patients with CHD had a positive perception of their life and their psychosocial functioning was even better than the norm. Although the quality of life was very good, their view on their disease was more pessimistic than 10 years ago, especially for patients with moderate/severe CHD.

Graphic abstract
New Osia® OSI200 active transcutaneous bone-anchored hearing device: how I do it
Authors: Chew Dylan , Proctor Vicki , Ray Jaydip 
Published: December 2022

Abstract
Introduction
The new Osia® OSI200 implant incorporates a receiver coil and Piezo Power™ Transducer into one monolithic unit. Appropriate planning and surgical approach is needed for suitable positioning of the device.

Method
To optimise the surgical field and provide tension-free wound closure our team have adopted a versatile ‘Sheffield-S’ post-auricular incision which remains hidden within the hairline.

Conclusion
This incision provides adequate exposure for device placement and bone polishing/recessing. The soft tissue approach has resulted in improved operative efficacy particularly in those patients with irregular cortical bone or where pre-existing osseointegrated implants need to be removed or avoided.
Zopiclone versus placebo for short-term treatment of insomnia in patients with advanced cancer—a double-blind, randomized placebo-controlled clinical multicenter phase IV trial
Authors: Jakobsen Gunnhild , Sjue Karin , Paulsen Ørnulf , Kaasa Stein , Hjermstad Marianne Jensen , Klepstad Pål 
Published: December 2022

Abstract

Purpose
Insomnia is frequent in patients with advanced cancer, and a variety of pharmacological agents is used to treat this condition. Still, few clinical trials have investigated the effectiveness of pharmacological sleep therapies in this patient group. We aimed to study the short-term effectiveness of zopiclone on sleep quality in patients with advanced cancer who report insomnia.

Methods
A randomized, double-blind, placebo-controlled, parallel-group, multicenter, phase IV clinical trial in adult patients with metastatic malignant disease and insomnia. Patients were treated with zopiclone or placebo for six subsequent nights. Primary end point was patient-reported sleep quality during the final study night (NRS 0–10). Secondary end points were patient-reported sleep onset latency (SOL) and total sleep time (TST).

Results
Forty-one patients were randomized, with 18 being analyzed in the zopiclone group and 21 in the placebo group. Median age was 66, median Karnofsky performance score was 80, and 56% were male. Mean sleep quality at end of study was 2.9 (CI 2.3 to 3.8) in the zopiclone group and 4.5 (CI 3.6 to 5.4) in the placebo group (p = 0.021). At end of study, SOL was significantly different between the treatment groups: zopiclone 29 min (CI 13 to 51) and placebo 62 min (CI 40 to 87) (p = 0.045). TST was not significantly different across groups: zopiclone 449 min (403 to 496) and placebo 411 min (CI 380 to 440) (p = 0.167).

Conclusion
Zopiclone improved short-term patient-reported sleep quality in this cohort of patients with advanced cancer.

Trial registration
ClinicalTrials.gov Identifier: NCT02807922.
DeepEOR: automated perioperative volumetric assessment of variable grade gliomas using deep learning
Authors: Zanier Olivier , Da Mutten Raffaele , Vieli Moira , Regli Luca , Serra Carlo , Staartjes Victor E. 
Published: December 2022

Abstract
Purpose
Volumetric assessments, such as extent of resection (EOR) or residual tumor volume, are essential criterions in glioma resection surgery. Our goal is to develop and validate segmentation machine learning models for pre- and postoperative magnetic resonance imaging scans, allowing us to assess the percentagewise tumor reduction after intracranial surgery for gliomas.

Methods
For the development of the preoperative segmentation model (U-Net), MRI scans of 1053 patients from the Multimodal Brain Tumor Segmentation Challenge (BraTS) 2021 as well as from patients who underwent surgery at the University Hospital in Zurich were used. Subsequently, the model was evaluated on a holdout set containing 285 images from the same sources. The postoperative model was developed using 72 scans and validated on 45 scans obtained from the BraTS 2015 and Zurich dataset. Performance is evaluated using Dice Similarity score, Jaccard coefficient and Hausdorff 95%.

Results
We were able to achieve an overall mean Dice Similarity Score of 0.59 and 0.29 on the pre- and postoperative holdout sets, respectively. Our algorithm managed to determine correct EOR in 44.1%.

Conclusion
Although our models are not suitable for clinical use at this point, the possible applications are vast, going from automated lesion detection to disease progression evaluation. Precise determination of EOR is a challenging task, but we managed to show that deep learning can provide fast and objective estimates.
Risk factors for primary Sjögren’s Syndrome: a systematic review and meta-analysis
Authors: Jin Liang , Dai Min , Li Chengyin , Wang Jing , Wu Bin 
Published: December 2022

Abstract
Objectives
The aim of this study was to analyze the risk factors for primary Sjögren’s Syndrome (pSS) by conducting a meta-analysis of observational studies.

Methods
Four electronic databases were searched from inception to August 2022. The search strategy included medical subject headings (MeSH) and text words. Outcomes were calculated and reported as the odds ratio (OR) and 95% confidence interval (CI).

Results
Twelve studies consisting of nine case–control and three cohort studies were analyzed. Significant positive relationships between infection, a family history of autoimmune disease in first-degree relatives, negative stressful life events, CGGGG insertion/deletion polymorphisms in the IRF5 gene and the onset of pSS were found, with pooled ORs and 95% CIs of 2.73 (1.93, 3.86), 5.93 (3.34, 10.52), 1.69 (1.27, 2.24) and 2.69 (1.97, 3.66), respectively. In contrast, the results showed that a history of smoking was not associated with the onset of pSS, with a pooled OR and 95% CI of 1.39 (0.76, 2.53). However, a statistically significant negative association between current smoking and pSS was detected, with a pooled OR and 95% CI of 0.4 (0.29, 0.83).

Conclusions
Our research indicated that infection, a family history of autoimmune disease in first-degree relatives, negative stressful life events and CGGGG insertion/deletion polymorphisms in the IRF5 gene might be risk factors for pSS. In contrast, our study demonstrated that a history of smoking was not associated with the onset of pSS, whereas current smoking was negatively associated with pSS onset.

Systematic review registration
We registered this review on INPLASY (https://inplasy.com/ ) under registration number INPLASY202230005.
Veliparib with frontline chemotherapy and as maintenance in Japanese women with ovarian cancer: a subanalysis of efficacy, safety, and antiemetic use in the phase 3 VELIA trial
Authors: Mizuno Mika , Ito Kimihiko , Nakai Hidekatsu , Kato Hidenori , Kamiura Shoji , Ushijima Kimio , Nagao Shoji , Takano Hirokuni , Okadome Masao , Takekuma Munetaka , Tokunaga Hideki , Nagase Satoru , Aoki Daisuke , Coleman Robert L. , Nishimura Yasuko , Ratajczak Christine K. , Hashiba Hideyuki , Xiong Hao , Katsumata Noriyuki , Enomoto Takayuki , Okamoto Aikou 
Published: December 2022

Abstract
Background
The phase 3 VELIA trial evaluated veliparib with carboplatin/paclitaxel and as maintenance in patients with high-grade serous ovarian carcinoma.

Methods
Patients with previously untreated stage III–IV high-grade serous ovarian carcinoma were randomized 1:1:1 to control (placebo with carboplatin/paclitaxel and placebo maintenance), veliparib-combination-only (veliparib with carboplatin/paclitaxel and placebo maintenance), or veliparib-throughout (veliparib with carboplatin/paclitaxel and veliparib maintenance). Randomization stratification factors included geographic region (Japan versus North America or rest of the world). Primary end point was investigator-assessed median progression-free survival. Efficacy, safety, and pharmacokinetics were evaluated in a subgroup of Japanese patients.

Results
Seventy-eight Japanese patients were randomized to control (n = 23), veliparib-combination-only (n = 30), and veliparib-throughout (n = 25) arms. In the Japanese subgroup, median progression-free survival for veliparib-throughout versus control was 27.4 and 19.1 months (hazard ratio, 0.46; 95% confidence interval, 0.18–1.16; p = 0.1 [not significant]). In the veliparib-throughout arm, grade 3/4 leukopenia, neutropenia, and thrombocytopenia rates were higher for Japanese (32%/88%/32%) versus non-Japanese (17%/56%/28%) patients. Grade 3/4 anemia rates were higher in non-Japanese (65%) versus Japanese (48%) patients. Early introduction of olanzapine during veliparib monotherapy maintenance phase may help prevent premature discontinuation of veliparib, via its potent antiemetic efficacy.

Conclusions
Median progression-free survival was numerically longer in Japanese patients in the veliparib-throughout versus control arm, consistent with results in the overall study population. Pharmacokinetics were comparable between Japanese and non-Japanese patients. Data for the subgroup of Japanese patients were not powered to show statistical significance but to guide further investigation.