bluuebunny/crossref_metadata_2025_split huggingface dataset:
KOMUNIKASI ANTAR KELUARGA MUSLIM BEDA BUDAYA DI PALANGKA RAYA
Authors: Ngalimun Ngalimun , Rahmawati Rahmawati 
Published: February 2022

This study aims to determine the model of communication between Muslim families of different cultures and inhibiting factors of communication. This research was conducted on couples of five families who married with different cultures in the Tanjung Pinang sub-district, Pahandut sub-district, Palangka Raya City. With the marriage of different cultures is expected to enrich the culture and can also be used as lessons for individuals who want to do the marriage. This type of research is descriptive qualitative, the sample of this study is 5 families. The communication model of 5 Muslim families with different cultures can be seen from the adaptation process that occurs in their respective families. In adapting there are various things that start from the adaptation of the language, through habits, through different food tastes and complement each other so that each family has a different communication model. Whereas the factors which hamper communication in the family are the difficulty of language adjustment, the existence of prejudice, the communication that occurs is one- way or there is no feedback and errors in the evaluation of the message delivered.
PENGARUH HARGA, PROMOSI DAN KUALITAS PELAYANAN TERHADAP KEPUASAN KONSUMEN DI CAFÉ KUPI DATU BANJARBARU
Authors: Susiladewi Susiladewi 
Published: February 2022

This study aims to determine and analyze the effect of Price, Promotion and Quality ofservices provided by Café Kupi Datu on customer satisfaction both partially andsimultaneously. This research is quantitative research. The research design uses formal research procedures that contain clear definitions of research objectives and information needs. To answer and achieve the research objectives, regression analysis will be used. Regression analysis is a statistical method that aims to see the direction of the relationship and the magnitude of influence between 2 or more variables in a linear form. Therefore, the research model in this study is Y = α + βX + e. The results showed that, it turns out that the independent variable that has the largest beta is the Price variable (X1) that is equal to 0.659 or by 65.9%. Therefore it can be said that the variable that has the greatest effect on customer satisfaction Café Kupi Datu is the variable X1 (Price) with a standard regression coefficient of 0.659. The results of the first hypothesis (H1) are the decision to reject H0 and accept Ha, which means the F test of the regression equation obtained from this study shows the results that, together with the three variables price, promotion and quality of service affect the consumer satisfactionat Café Kupi Datu .
TEACHING WITHOUT STUDENTS: EFL PRE-SERVICE TEACHERS’ EXPERIENCES TEACHING IN PANDEMIC TIME
Authors: Riyanti Dwi 
Published: February 2022

Since the outbreak of the Covid-19 pandemic, teaching and learning activities have changed dramatically. Within the Indonesian context, for example, beginning March 2020, the Indonesian government applied a social distancing policy. The situation forced both students and teachers to study and teach from home as the schools were closed to prevent the spread of the Coronavirus. This included how pre-service teachers learnt to teach. Intended to explore pre-service English teachers’ experiences related to their teaching practicum in this pandemic time, this paper focuses on gaining in-depth information related to how the research participants view their experiences during a microteaching class at an Indonesian university. The study involved six pre-service teachers who took the microteaching class. The main data were collected from pre-service teachers through written reflection and from an open-ended questionnaire. In addition, recorded videos of participants’ teaching practices were also used to triangulate the data. Data analysis was qualitatively to see the emerging themes. The findings indicates that teacher candidates in the study view their microteaching experiences as both positive and negative ways. They consider it as a positive experience as they could have high confidence in teaching. It is a negative experience because they did not have experience managingthe classroom. Despite their mixed experiences, the participants in the study still consider their teaching practice experiences to be useful in preparing their teaching practicum at schools.
Um encontro sobre espaço: discursos sobre população em situação de rua, plantas daninha e não quisto
Authors: Negretti Natalia 
Published: February 2022

O objetivo deste texto é, a partir de três imagens, que chamo de obras, por seu caráter discursivo, problematizar o vínculo entre duas populações-símbolo, plantas daninhas e pessoas em situação de rua, por meio de um vinco em comum: não quisto. O texto busca compreender o encontro dessas fontes discursivas como elaborares sobre espaço e disputas, contemplando um diálogo sobre cidade nas suas variadas dimensões no que refere a convívio, desigualdade e territórios morais.
Laboratory and Field Experimental Study of Underwater Inflatable Co-prime Sonar Array (UICSA)
Authors: Li Yanjun , Ouyang Bing , Zhou Tongdi , Thomas Jordan , Bavar Shadi , Weber Ethan , Michieletto Lorenzo , Su Tsung-chow , Ahmad Fauzia 
Published: February 2022

This paper discusses the design and initial testing of a novel hydrophone array system dubbed the Underwater Inflatable Co-prime Sonar Array (UICSA). The UICSA will be a crucial component of an underwater deployable sensing network that can be rapidly deployed using compact autonomous underwater vehicles (AUVs). The UICSA initially is packed in a compact container to fit the payload space of an AUV. After deployment, the UICSA expands to its predetermined full length to acquire sensing data for source localization. More specifically, the mechanical compression of the UICSA is achieved through a non-rigid array support structure, which consists of flexible inflatable segments between adjoining hydrophones that are folded in order to package the UICSA for deployment. The system exploits compression in hydrophone layouts by utilizing a sparse array configuration, namely the co-prime array since it requires fewer hydrophones than a uniform linear array of the same length to estimate a given number of sources. With two-way compression, the storage, handling, and transportation of the compactly designed UICSA is convenient, particularly for the AUVs with limited payload space. The deployment concept and process are discussed, as well as the various UICSA designs of different support structures are described. A comparison of the various mechanical designs is presented and a novel hybrid-based expansion prototype is documented in detail. Laboratory study results of the UICSA prototype are presented that include water-swollen material tests in a pressurized environment and water tank validation of the inflation process. The UICSA prototype also has been deployed in the Harbor Branch channel to validate the performance, the related field test details and source localization results.
Pendampingan Perencanaan Bangunan Gedung Masjid Al-Awwabin Kelurahan Karang Balik Kota Tarakan
Authors: Utomo Edy , Mahendra Zulfikhar Ade , Haryanti Giar Tri 
Published: February 2022

Al-Awwabin Mosque is a mosque built in 1967. Currently the condition of the building is no longer able to accommodate pilgrims. Based on this, the mosque administrator took the initiative to build a new mosque, with a more adequate capacity. However, the mosque administrator experienced some obstacles in planning process of the mosque, including 1. Complexity of land topography problems, 2. Form of architectural design, structure, and preparation of the necessary budget plan, 3. The absence of human resources that have adequate competence in building planning. Based on this, the PKM team from the Department of Civil Engineering, University of Borneo Tarakan strives to make a scientific contribution in the planning of the mosque building, which aims to produce a mosque design with adequate capacity and has architectural value and structural strength in accordance with applicable standardization. The method is initiated by mapping the land, soil investigation (CPT), making preliminary architectural designs, analyzing building structures, making detailed drawings of building construction, and finally calculating the value of the required cost budget plan. The results of this activity is to provide an alternative design with a capacity of 659 worshippers, greater than the capacity of the mosque today. The resulting design of the new mosque consists of 3 floors of the building, where the 1st floor serves as a vehicle parking area and secretariat office, the 2nd and 3rd floors function as the main worship space. The construction of the mosque uses reinforced concrete material with a deep foundation that is Strouss Pile at a depth of 13,00 meters. The estimated value of the cost budget plan is Rp. 10.735.848.000,- based on the basic price of employment and material wages in the Tarakan City area. All design documents consisting of detail drawings, structure design, and DED are submitted to the mosque administrator, which will further serve for the management of building permits as well as references in the implementation of mosque construction. Keywords : Design of the mosque; Community service; Structure of the building; Civil engineering.
Leaving the Academic Niche–Rhoda Erdmann (1870–1935) and the Democratization of Tissue Culture Research
Authors: Fangerau Heiner 
Published: February 2022

In the years after Ross Harrison published his pivotal paper on nerve fiber regeneration in 1907, researchers following his line of research presented tissue culture techniques as an extremely sensitive, difficult, and almost occult methodology. When Philip R. White published a manual on tissue culturing in 1954, he declared that he wanted to disenchant this formerly mystified field of study. With a similar aim Rhoda Erdmann had published a comparable manual more than 30 years before in 1922. Her intention was to offer a book that would make the method “a common property of those who want to do biological research in the future.” When science was about to move from little science to big science, Erdmann tried to democratize tissue culture knowledge. Rhoda Erdmann was in many aspects an extraordinary scholar deviating from the norm. She was one of the few women in the field, working as a low-level assistant at the Robert Koch Institute in Berlin before she took the opportunity to work as a research fellow with Ross Harrison in Yale. She was imprisoned during the First World War on the accusation of being a German spy. After she could return to Germany in 1919, she established a laboratory for experimental cell research in Berlin. In 1929 she was one of the first women to be appointed a professor in Germany. The paper focuses Erdmann’s attempts at distributing practical tissue culturing knowledge. Based on her and other scholars’ research work on nutrient media for cell cultures, and the attempts to optimize these basic tools for different species, this contribution examines the hypothesis that this work constituted an academic niche for underprivileged scientists. The paper analyzes whether Erdmann, due to her extraordinary characteristics, had to use certain niches in the academic world (topics, places, techniques, communities) to pursue her research, and whether her attempts at democratizing her techniques can also be read as an attempt to move out of the niche to gain academic recognition.
Antioxidant Aryl-Substituted Phthalan Derivatives Produced by Endophytic Fungus Cytospora rhizophorae
Authors: Liu Hongxin , Liu Zhaoming , Zhang Yanjiang , Chen Yuchan , Wang Huan , Tan Haibo , Zhang Weimin 
Published: February 2022

Six new phthalan derivatives cytorhizophins D-I (1-6) as well as three known derivatives cytorhizophin C, pestacin and rhizophol B were isolated from Cytospora rhizophorae. Among them, cytorhizophins D-E (1-2) and F-G (3-4) were two pairs of diastereoisomers, all of them featuring a 1-phenyl-1,3-dihydroisobenzofuran scaffold with a highly oxygenated O-linked isopentenyl unit. Besides, cytorhizophins H-I (5-6) represent the first examples of phthalide family with fascinating 6/6/6/5 tetracyclic ring system fusing as unprecedented furo [4,3,2-kl]xanthen-2 (10bH)-one skeleton. The structures of the new phthalan derivatives were extensively confirmed by detail spectroscopic analysis. The partial absolute configurations of compounds 1-6 were established through electronic circular dichroism (ECD) calculations. Moreover, compounds 1-4 showed remarkable antioxidant activities with EC50 values ranging from 5.86 to 26.80 μM, which were better than or comparable to that of ascorbic acid (positive control).
Trace Level Quantification of 4-Methyl-1-nitrosopiperazin in Rifampicin Capsules by LC-MS/MS
Authors: Tao Xiaosha , Tian Ye , Liu Wan-Hui , Yao Shangchen , Yin Lihui 
Published: February 2022

Rifampicin is a first-line anti-tuberculosis drug. However, in August 2020, the presence of 1-methyl-4-nitrosopiperazine (MNP), a nitrosamine impurity, was detected by the United Stated Food and Drug Administration (US FDA) in rifampicin capsules. Consequently, the development of efficient methods for the detection of MNP is an important objective. In this study, the MNP present in rifampicin capsules was detected using LC-MS/MS. A total of 27 batches from nine manufacturers in the Chinese market were tested, with MNP (0.33–2.36 ppm) being detected in all samples at levels exceeding the maximum acceptable intake limit of 0.16 ppm initially set by the FDA. However, after considering the associated benefits and risks, the FDA-approved limit was revised to 5 ppm; hence, all the samples examined herein exhibited MNP levels well below the required limit. Furthermore, the results of forced degradation experiments suggest that MNP is formed by the thermal degradation of rifampicin.
Outcomes After a Single Ovarian Stimulation Cycle in Women of Advanced Reproductive Age: A Retrospective Analysis
Authors: Liu Mengdi , Zhao Xusheng , Peng Yuanyuan , Zheng Jiahua , Guo Kaixuan , Fan Yanli , Jiang Lei , Yang Aimin , Cui Na , Hao Guimin , Wang Wei 
Published: February 2022

ObjectivesPrevious studies showed that age is the most important factor that determines the outcome after embryo transfer (ET), with either in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), regardless whether fresh or frozen cycles. The average cumulative live birth rate (CLBR) following a single ovarian stimulation cycle in women of advanced reproductive age (≥38 years of age) has been reported to be 22.6–34.1%. The purpose of this study is to compare the CLBR after a single ovarian stimulation cycle in women of different advanced reproductive age bracket (38/39, 40/41, 42/43 years of age or older), and to explore the factors (e.g., age, type of infertility, body mass index (BMI), ovarian stimulation protocols) associated with CLBR.MethodsThis retrospective analysis included all women of advanced reproductive age (38 years or older) undergoing IVF or ICSI at authors’ institute during a period from January 1, 2016 to December 31, 2018. The study protocol was approved by the Ethics Committee of the Second Hospital of Hebei Medical University (No. 2021-P045). Subjects with underlying diseases were excluded from analysis. The last follow-up was conducted in December 2020, with minimal 2-year follow-up.ResultsThe final analysis included 826 women (40.00 ± 2.10 years of age at the time of ovarian stimulation; n = 633 and 193 for IVF-ET and ICSI-ET, respectively). The number of women in each age bracket was: 424 for 38/39 y, 226 for 40/41 y, 118 for 42/43 y, and 58 for ≥44 y. The number of transferable embryos was 2 (interquartile range: 2,4) for 38/39 y, 2 (2,3) for 40/41 y, 2 (2,3) for 42/43 y, and 2 (1.75,3) for ≥44 y. The rate of fresh embryo transfer was comparable (62.03–72.58%) among the 4 age brackets. The average CLBR following a single cycle was 26.27% in the overall study population, 32.31% for 38/39 y, 26.99% for 40/41 y, 14.4% for 42/43 y, and 3.44% for ≥44 y (P &lt;0.001). In multivariate regression, CLBR was independently associated with younger age (OR for each year: 1.538, 95%CI: 1.193, 1.984) and higher number of transferable embryos (OR for each embryo: 1.495, 95%CI: 1.297, 1.722). CLBR differed significantly in the 38/39 group (P = 0.014), with higher rate in women receiving the Gonadotropin-releasing hormone agonist (GnRH-a) long or GnRH-a ultra-long protocols.ConclusionsForty-two years of age seemed to be a critical cutoff to achieve reasonable level of CLBR after a single ovarian stimulation cycle in women of advanced reproductive age.
A New Prognostic Risk Score: Based on the Analysis of Autophagy-Related Genes and Renal Cell Carcinoma
Authors: He Minxin , Li Mingrui , Guan Yibing , Wan Ziyan , Tian Juanhua , Xu Fangshi , Zhou Haibin , Gao Mei , Bi Hang , Chong Tie 
Published: February 2022

Introduction: Clear cell renal cell carcinoma (ccRCC) patients suffer from its high recurrence and metastasis rate, and a new prognostic risk score to predict individuals with high possibility of recurrence or metastasis is in urgent need. Autophagy has been found to have a dual influence on tumorigenesis. In this study we aim to analyze autophagy related genes (ATGs) and ccRCC patients and find a new prognostic risk score. Method: Analyzing differential expression genes (DEGs) in TCGA-KIRC dataset, and took intersection with ATGs. Through lasso, univariate, and multivariate cox regression, DEGs were chosen, and the coefficients and expression levels of them were components constructing the formula of risk score. We analyzed mRNA expression of DEGs in tumor and normal tissue in ONCOMINE database and TCGA-KIRC dataset. The Human Protein Atlas (HPA) was used to analyze protein levels of DEGs. The protein-protein interaction (PPI) network was examined in STRING and visualized in cytoscape. Functional enrichment analysis was performed in RStudio. To prove the ability and practicibility of risk score, we analyzed univariate and multivariate cox regression, Kaplan-Meier curve (K-M curve), risk factor association diagram, receiver operating characteristic curve (ROC curve) of survival and nomogram, and the performance of nomogram was evaluated by calibration curve. Then we further explored functional enrichment related to risk groups through Gene Set Enrichment Analysis (GSEA), weighted gene co-expression network analysis (WGCNA), and Metascape database. At last, we investigated immune cell infiltration of DEGs and two risk groups through TIMER database and “Cibersort” algorithm.Result: We identified 7 DEGs (BIRC5, CAPS, CLDN7, CLVS1, GMIP, IFI16, and TCIRG1) as components of construction of risk score. All 7 DEGs were differently expressed in ccRCC and normal tissue according to ONCOMINE database and TCGA-KIRC dataset. Functional enrichment analysis indicated DEGs, and their most associated genes were shown to be abundant in autophagy-related pathways and played roles in tumorigenesis and progression processes. A serious analysis proved that this risk score is independent from the risk signature of ccRCC patients.Conclusion: The risk score constructed by 7 DEGs had the ability of predicting prognosis of ccRCC patients and was conducive to the identification of novel prognostic molecular markers. However, further experiment is still needed to verify its ability and practicability.
Identifying Key Genes and Functionally Enriched Pathways of Diverse Adipose Tissue Types in Cattle
Authors: Pan Cuili , Yang Chaoyun , Wang Shuzhe , Ma Yun 
Published: February 2022

Background: Fat is a tissue that not just stores energy and plays a protective role; it is also a vital endocrine organ that generates and integrates signals to influence metabolism. Meanwhile, the excessive accumulation of lipids in adipose tissue can lead to metabolic disturbance and diseases. To date, the complicated molecular mechanisms of bovine adipose tissue are still unknown. This study aimed to identify key genes and functionally enriched pathways in various adipose tissue types.Results: The RNAseq data of 264 samples were downloaded from Gene Expression Omnibus (GEO) and analyzed by weighted gene co-expression network analysis (WGCNA). We identified 19 modules that significantly associated with at least one adipose tissue type. The brown module from GSE39618 was most closely associated with intramuscular fat tissue, which contained 550 genes. These genes were significantly enriched in pathways that related to inflammation and disease, such as TNF signaling pathway, IL-17 signaling pathway, and NF-kappa B signaling pathway. The pink module (GSE39618) that contained 58 genes was most closely associated with omental fat tissue. The turquoise (GSE39618), blue (GSE116775), and yellow (GSE65125) module were most closely associated with subcutaneous fat tissue. Genes in these modules were significantly enriched in pathways related to fat metabolism, such as the PPAR signaling pathway, fatty acid metabolism and PI3K-Akt signaling pathway. At last, key genes for intramuscular fat (PTGS2 and IL6), omental fat (ARHGEF5 and WT1), and subcutaneous fat (KIT, QR6Q1, PKD2L1, etc.) were obtained and verified. In addition, it was found that IL10 and VCAM1 might be potential genes to distinguish adipose and muscle.Conclusion: The study applied WGCNA to generate a landscape of adipose tissue and provide a basis for identifying potential pathways and hub genes of different adipose tissue types.
Activation of RARα Receptor Attenuates Neuroinflammation After SAH via Promoting M1-to-M2 Phenotypic Polarization of Microglia and Regulating Mafb/Msr1/PI3K-Akt/NF-κB Pathway
Authors: Tian Yang , Liu Binbing , Li Yuchen , Zhang Yongzhi , Shao Jiang , Wu Pei , Xu Chao , Chen Guangduo , Shi Huaizhang 
Published: February 2022

Background and PurposeSubarachnoid hemorrhage (SAH) is a life-threatening subtype of stroke with high rates of mortality. In the early stages of SAH, neuroinflammation is one of the important mechanisms leading to brain injury after SAH. In various central nervous system diseases, activation of RARα receptor has been proven to demonstrate neuroprotective effects. This study aimed to investigate the anti-inflammatory effects of RARα receptor activation after SAH.MethodsInternal carotid artery puncture method used to established SAH model in Sprague-Dawley rats. The RARα specific agonist Am80 was injected intraperitoneally 1 hour after SAH. AGN196996 (specific RARα inhibitor), Msr1 siRNA and LY294002 (PI3K-Akt inhibitor) were administered via the lateral ventricle before SAH. Evaluation SAH grade, neurological function score, blood-brain barrier permeability. BV2 cells and SH-SY5Y cells were co-cultured and stimulated by oxyhemoglobin to establish an in vitro model of SAH. RT-PCR, Western blotting, and immunofluorescence staining were used to investigate pathway-related proteins, microglia activation and inflammatory response. Results: The expression of RARα, Mafb, and Msr1 increased in rat brain tissue after SAH. Activation of the RARα receptor with Am80 improved neurological deficits and attenuated brain edema, blood brain barrier permeability. Am80 increased the expression of Mafb and Msr1, and reduced neuroinflammation by enhancing the phosphorylation of Akt and by inhibiting the phosphorylation of NF-κB. AGN196996, Msr1 siRNA, and LY294002 reversed the therapeutic effects of Am80 by reducing the expression of Msr1 and the phosphorylation of Akt. In vitro model of SAH, Am80 promoted M1-to-M2 phenotypic polarization in microglia and suppressed the nuclear transcription of NF-κB.ConclusionActivation of the RARα receptor attenuated neuroinflammation by promoting M1-to-M2 phenotypic polarization in microglia and regulating the Mafb/Msr1/PI3K-Akt/NF-κB pathway. RARα might serve as a potential target for SAH therapy.