bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breast cancer incidence among women with a family history of breast cancer by relative's age at diagnosis
Authors: Durham Danielle D. , Abraham Linn A. , Roberts Megan C. , Khan Carly P. , Smith Robert A. , Kerlikowske Karla , Miglioretti Diana L. 
Published: October 2022

BackgroundWomen with a first‐degree family history of breast cancer are often advised to begin screening when they are 10 years younger than the age at which their relative was diagnosed. Evidence is lacking to determine how much earlier they should begin.MethodsUsing Breast Cancer Surveillance Consortium data on screening mammograms from 1996 to 2016, the authors constructed a cohort of 306,147 women 30–59 years of age with information on first‐degree family history of breast cancer and relative's age at diagnosis. The authors compared cumulative 5‐year breast cancer incidence among women with and without a first‐degree family history of breast by relative's age at diagnosis and by screening age.ResultsAmong 306,147 women included in the study, approximately 11% reported a first‐degree family history of breast cancer with 3885 breast cancer cases identified. Women reporting a relative diagnosed between 40 and 49 years and undergoing screening between ages 30 and 39 or 40 and 49 had similar 5‐year cumulative incidences of breast cancer (respectively, 18.6/1000; 95% confidence interval [CI], 12.1, 25.7; 18.4/1000; 95% CI, 13.7, 23.5) as women without a family history undergoing screening between 50–59 years of age (18.0/1000; 95% CI, 17.0, 19.1). For relative's diagnosis age from 35 to 45 years of age, initiating screening 5–8 years before diagnosis age resulted in a 5‐year cumulative incidence of breast cancer of 15.2/1000, that of an average 50‐year‐old woman.ConclusionWomen with a relative diagnosed at or before age 45 may wish to consider, in consultation with their provider, initiating screening 5–8 years earlier than their relative's diagnosis age.
DNA methylation analysis in urinary samples: A useful method to predict the risk of neoplastic recurrence in patients with urothelial carcinoma of the bladder in the high‐risk group
Authors: Pierconti Francesco , Rossi Esther Diana , Cenci Tonia , Carlino Angela , Fiorentino Vincenzo , Totaro Angelo , Sacco Emilio , Palermo Giuseppe , Iacovelli Roberto , Larocca Luigi Maria , Bassi Pier Francesco , Martini Maurizio 
Published: October 2022

AbstractBackgroundRecently, it was reported that the Bladder EpiCheck test is likely to represent a valid tool in the diagnostic process of patients who have suspected bladder carcinoma, with some controversial management decisions because of the technical limitations of cytology.MethodsTwo hundred ninety patients with a diagnosis of nonmuscle‐invasive bladder carcinoma who were admitted at the authors’ department from March 2019 to December 2019 were treated and followed for 1 year. During follow‐up, all patients were evaluated by voided urine cytology, white‐light cystoscopy (according to European Association of Urology guidelines), and the Bladder EpiCheck test.ResultsThe cytologic diagnoses of high‐grade urothelial carcinoma (HGUC) and suspicious for HGUC were histologically confirmed in 5 of 20 patients (25%) who had quantitative Bladder EpiCheck scores (EpiScores) from 60 to 69, in 23 of 36 patients (64%) who had EpiScores from 70 to 79, and in 42 of 56 patients (75%) and 57 of 63 patients (90%) who had EpiScores between 80 and 89 and EpiScores >90, respectively. Of 48 patients who had a cytologic diagnosis of HGUC or suspicious for HGUC with EpiScores ≥60 and negative histology, 20 (42%) had a recurrence of HGUC, which was cytologically and histologically confirmed, at 6–12 months during follow‐up.ConclusionsTo the best of the authors’ knowledge, this is the first study in which patients at high risk for HGUC were stratified using the Bladder EpiCheck EpiScore. The results validate this methylation analysis tool as a useful method for predicting recurrent HGUC during the follow‐up of patients with nonmuscle‐invasive bladder carcinoma.
Retrospective study in U.S. commercial sorghum breeding: III. Nitrogen internal efficiency
Authors: Demarco Paula Andrea , Mayor Laura , Messina Carlos , Prasad P. V. Vara , Morris Geoffrey P. , Ciampitti Ignacio Antonio 
Published: October 2022

AbstractRetrospective studies are critical to investigate changes in physiological traits related to nitrogen (N) uptake and yield formation. N is a key yield‐limiting nutrient in sorghum (Sorghum bicolor L. Moench), as in most crops, so improving its N internal efficiency (NIE, yield to N uptake ratio) could increase productivity and sustainability. Understanding changes in N efficiency across time linked to carbon (C) economy can provide insights for future breeding targets. This study aims to characterize N and C dynamics (via studying changes in water‐soluble carbohydrates, WSC) of 20 commercial U.S. sorghum hybrids released from 1963 to 2017. Field trials were conducted during the 2018 and 2019 growing seasons in Riley County, KS. Seasonal changes in biomass accumulation, N uptake, and WSC were characterized during both vegetative and reproductive periods. Modern hybrids had greater NIE compared with those from the 1960s. Overall, beyond the yield gain documented for modern sorghum hybrids, the NIE increased at the expense of a reduction in grain N and, in minor proportion, due to increase in the N harvest index (NHI) at maturity for newer relative to older hybrids. Newer hybrids evidenced greater N remobilization from the stover to the grains during the reproductive period. This study demonstrates the physiological mechanisms for an increase in N and C utilization behind yield genetic gain for sorghum hybrids. Future yield gain in sorghum could be pursued by enhancing N uptake to sustain further genetic progress.
ROTEE: Remora Optimization and Tunicate swarm algorithm‐based Energy‐Efficient cluster‐based routing for EH‐enabled heterogeneous WSNs
Authors: Gupta Amar Deep , Rout Ranjeet Kumar 
Published: October 2022

SummarySince the development of Wireless Sensor Networks (WSNs), the limited battery of the sensor nodes has been an unavoidable concern. Hence, to keep the WSNs operational for a longer possible duration, the recharging of node's battery through harvesting the ambient energy from surroundings (for an example, solar energy) has been proposed. In this work, we focus not only on utilizing the energy harvesting (EH)‐enabled sensor nodes for routing purposes but also introduce a novel hybrid optimization ROATSA that uses Remora Optimization Algorithm (ROA) and Tunicate Swarm Algorithm (TSA) for energy‐efficient cluster‐based routing. The proposed work is termed as ROA and TSA‐based Energy‐Efficient Cluster‐based Routing for EH‐enabled WSN (ROTEE). Hybrid ROATSA is chosen due to enhanced convergence and exploitation capabilities. To reduce the financial burden on the network, we use only four EH‐enabled nodes and locate them at each periphery of the network, equidistant to each other and the other nodes are 3‐level energy heterogeneous sensor nodes. The selection of cluster head (CH) is optimized through ROATSA by considering profile index of each node by evaluating them at energy, distance, load balancing, node density, the delay involved, and network's average energy. The proposed work ROTEE shows supreme performance against the recently proposed clustering techniques.
Squid‐like soft heat pipe for multiple heat transport
Authors: Kang Zhanxiao , Jiang Shoukun , Hong Yang , Fan Jintu 
Published: October 2022

AbstractSoft heat pipes are vital in many applications. Inspired by the structure of a squid, we proposed a squid‐like soft heat pipe with multiple heat transport branches that has excellent flexibility and outstanding thermal performance. Each branch could transport heat to different locations for multiple heating or cooling applications. The proposed soft heat pipe worked as a pulsating heat pipe with a unidirectional flow of liquid slugs and vapor bubbles. Its thermal performance was investigated at different heating temperatures, bending angles, and inclination angles. The result showed that the highest equivalent thermal conductivity of the squid‐like soft heat pipe could be up to 6750 W/(m · K), almost 17 times that of copper. Besides, the bending angle had little effect on its thermal performance, with the equivalent thermal conductivity reducing 10%–13% when the heat pipe was bent from 0° to 90°. The thermal performance of the soft heat pipe was affected by the inclination angle, with the equivalent thermal conductivity reducing 20%–25% as the inclination angle was reduced from 90° to 30°. The proposed soft heat pipe is scalable by increasing the tube length and branches. It has many promising applications like waste heat recovery, electronic device cooling, personal thermal management, and renewable energy harvesting.
Study on coffee flavour of various pour‐over brews
Authors: Chen Chien‐Li , Kuo Yu‐Hsuan , Fang Mingchih 
Published: October 2022

AbstractCoffee filters and drippers advertised with various functions such as balanced flavour, sweeter taste and plentiful coffee scene are popular options for hand‐brewed coffee lovers. This study investigated the flavour of filtered coffee brewed by various coffee filters including Hario V60 filter, Kalita filter, flannel cloth filter and stainless‐steel (screen) filter based on the physical and chemical properties of the beverages. The results showed that the extraction time of V60 and flannel cloth filter were shorter. Kalita filter offered longer extraction time and obtained the highest amount of chlorogenic acids than other drippers. In the volatile profiles of aroma compounds, flannel cloth and stainless‐steel filters obtained higher total volatile compounds that may due to less volatiles were absorbed by filter material compared with paper filters, V60 and Kalita. Combined physical and chemical data among four extraction methods, partial least squares‐discriminant analysis (PLS‐DA) was able to separate samples into approximate four clusters. 2‐Acetylfuran and 3‐methyl‐phenol were found fluctuated wildly among samples and would be important factors for the differentiation of pour‐over coffee. This study suggested that the four coffees brewed by different filters have their own characteristic aroma profiles and did show their differences based on the chemical compositions caused by dripping speed and the interactions with filters.
Production and characterization of nondairy gluten‐free fermented beverage based on buckwheat and lentil
Authors: Mousavi Mir‐Hossein , Gharekhani Mehdi , Alirezalu Kazem , Roufegarinejad Leila , Azadmard‐Damirchi Sodeif 
Published: October 2022

AbstractThe present study aimed to optimize the formulation of buckwheat/lentil gluten‐free beverages fermented with Lactobacillus plantarum and Bifidobacterium bifidum. Physicochemical parameters of 14 different beverages, such as pH, acidity, total solids, ash, total phenol content, antioxidant activity, and sensory test, were assessed after 24 h of fermentation. The results showed that the numbers of viable cells of lactobacilli and bifidobacteria on the first day of the experiment were 9.9 and 9.6 log (CFU ml−1), respectively, which were over 9 log (CFU ml−1). During 24 h from the fermentation, the number of viable cells for all beverages decreased, which reached an average probiotic count of 8.81 log (CFU ml−1) that was statistically significantly different from the probiotic count before fermentation (p < .05). Cell viability was evaluated and shelf life was estimated during 15‐day refrigerated storage. At the end of the storage (15th day), the beverages contained an average of 8.4 log (CFU ml−1) of live lactobacilli cells and 7.8 log (CFU ml−1) of viable bifidobacterial cells. The optimized levels of independent factors for sprouted buckwheat and lentil flours were 51.96% and 48.04%, respectively. The optimized probiotic beverage was contained 0.25 (% lactic acid) acidity, 5.7 pH, 7.9% total solids, 0.4% ash, 41.02% DPPH, 26.96 (mg GAE/ml) phenol compounds, and 8.65 log (CFU ml−1) probiotic count. The optimized beverage had distinct organoleptic properties on day 15 of refrigerated storage. This study showed that Bifidobacterium bifidum can be used for the development of potentially probiotic beverage with sprouted buckwheat and lentil.
Profiling of cell‐free DNA methylation and histone signatures in pediatric NAFLD: A pilot study
Authors: Buzova Diana , Braghini Maria Rita , Bianco Salvatore Daniele , Lo Re Oriana , Raffaele Marco , Frohlich Jan , Kisheva Antoniya , Crudele Annalisa , Mosca Antonella , Sartorelli Maria Rita , Balsano Clara , Cerveny Jan , Mazza Tommaso , Alisi Anna , Vinciguerra Manlio 
Published: October 2022

Abstract
Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in children and adolescents, increasing the risk of its progression toward nonalcoholic steatohepatitis (NASH), cirrhosis, and cancer. There is an urgent need for noninvasive early diagnostic and prognostic tools such as epigenetic marks (epimarks), which would replace liver biopsy in the future. We used plasma samples from 67 children with biopsy‐proven NAFLD, and as controls we used samples from 20 children negative for steatosis by ultrasound. All patients were genotyped for patatin‐like phospholipase domain containing 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), membrane bound O‐acyltransferase domain containing 7 (MBOAT7), and klotho‐β (KLB) gene variants, and data on anthropometric and biochemical parameters were collected. Furthermore, plasma cell‐free DNA (cfDNA) methylation was quantified using a commercially available kit, and ImageStream(X) was used for the detection of free circulating histone complexes and variants. We found a significant enrichment of the levels of histone macroH2A1.2 in the plasma of children with NAFLD compared to controls, and a strong correlation between cfDNA methylation levels and NASH. Receiver operating characteristic curve analysis demonstrated that combination of cfDNA methylation, PNPLA3 rs738409 variant, coupled with either high‐density lipoprotein cholesterol or alanine aminotransferase levels can strongly predict the progression of pediatric NAFLD to NASH with area under the curve >0.87. Conclusion: Our pilot study combined epimarks and genetic and metabolic markers for a robust risk assessment of NAFLD development and progression in children, offering a promising noninvasive tool for the consistent diagnosis and prognosis of pediatric NAFLD. Further studies are necessary to identify their pathogenic origin and function.
Strong signals in HR management: How the configuration and strength of an HR system explain the variability in HR attributions
Authors: Meier‐Barthold Madleen , Biemann Torsten , Alfes Kerstin 
Published: October 2022

AbstractIn explaining the effectiveness of a human resource (HR) system within an organization, scholars have turned their attention to HR attributions, which capture employees' perceptions about the intentions behind their organization's HR practices, and have demonstrated that an HR system's content and process of communication drive employees to form specific HR attributions. However, current research has not yet explained why HR attributions differ among employees. We investigate the variability in HR attributions among individuals and the organizational factors that influence this variability. Using signaling theory and the concept of situational strength, we argue that employees' HR attributions vary less when signals sent by HR management are unambiguous and the conveyed information is consistent. Using an online scenario‐based experiment with 760 participants, our findings reveal that the configuration and the strength of an HR system as well as their combination have significant effects on the variability in HR attributions among employees, and these effects differ for the different HR attributions.
Bioconvective Casson nanofluid flow toward stagnation point in non‐Darcy porous medium with buoyancy effects, chemical reaction, and thermal radiation
Authors: Sangeetha Ekambaram , De Poulomi 
Published: October 2022

AbstractThe emphasis on non‐Newtonian fluid encountered in biomedical, pharmaceuticals, mining, food, chemical, and plastics industries and in noticeably enormous diverse industrial applications influenced this article. This study is accomplished in a non‐Darcy porous stretching surface to investigate the stagnation point of bioconvective Casson nanofluid. Chemical reaction, applied consistent magnetic field, radiative heat transfer, and buoyancy force consequences are studied for numerical examination. Composed of nonlinear partial differential equations for the above presumptions and reforming them into ordinary differential equations by means of compatible transformations are enforced. Adopting the fifth order Runge–Kutta Felhberg method with the shooting technique obtained a numerical solution. Obtained solutions are authenticated by comparing previous solutions. The major finding includes the reduction of the Casson parameter on the skin friction coefficient.
Maternal mid‐upper arm circumference to predict small for gestational age: Findings in a Zambian cohort
Authors: Appiagyei Ashley , Vwalika Bellington , Spelke M. Bridget , Conner Madelyn G. , Mabula‐Bwalya Chileshe M. , Kasaro Margaret P. , Honart Anne West , Kumwenda Andrew , Stringer Elizabeth M. , Stringer Jeffrey S. A. , Price Joan T. 
Published: October 2022

AbstractObjectiveTo compare the performance of mid upper arm circumference (MUAC) and body mass index (BMI) for prediction of small for gestational age (SGA) in Zambia.MethodsThis is a secondary analysis of an ongoing clinical cohort that included women with a single gestation and MUAC measured before 24 weeks of pregnancy. We assessed relationships between maternal MUAC and birth weight centile using regression. The performance of MUAC and BMI to predict SGA was compared using receiver operating characteristic curves and the effect of maternal HIV was investigated in sub‐group analyses.ResultsOf 1117 participants, 847 (75%) were HIV‐negative (HIV−) and 270 (24%) were HIV‐positive (HIV+). Seventy‐four (7%) delivered severe SGA infants (<3rd centile), of whom 56 (76%) were HIV− and 18 (24%) were HIV+ (odds ratio [OR] 1.01, 95% confidence interval [CI] 0.58–1.75). MUAC was associated with higher birth weight centile (+1.2 centile points, 95% CI 0.7–1.6; P < 0.001); this relationship was stronger among HIV+ women (+1.7 centile points, 95% CI 0.8–2.6; P < 0.001) than HIV− women (+0.9 centile points, 95% CI 0.4–1.4; P = 0.001). The discriminatory power was similar, albeit poor (area under the curve [AUC] < 0.7), between MUAC and BMI for the prediction of SGA. In stratified analysis, MUAC and BMI showed excellent discrimination predicting severe SGA among HIV+ (AUC 0.83 and 0.81, respectively) but not among HIV− women (AUC 0.64 and 0.63, respectively).ConclusionMaternal HIV infection increased the discrimination of both early pregnancy MUAC and BMI for prediction of severe SGA in Zambia.Clinical Trial NumberClinicalTrials.gov (NCT02738892).
Combined effects of age and endometriosis on ovarian reserve in women with infertility
Authors: Feferkorn Ido , Suarthana Eva , Kigloo Hormoz Nassiri , Abow‐Mohamed Ikram , Golyari Yasna , Tulandi Togas 
Published: October 2022

AbstractObjectiveTo evaluate the combined effects of age and endometriosis on ovarian reserve in women with infertility.MethodsWe conducted a cross‐sectional study using an institutional database. Women with sonographic, laparoscopic, or histologic evidence of endometriosis were defined as the study group and the remaining women served as a control group. We evaluated demographic and clinical characteristics of the groups as a whole and stratified the patients into those aged 35 years or older and those younger than 35 years at the time of ovarian reserve testing.ResultsOf a total of 656 women included in the final analysis, 71 women had a diagnosis of endometriosis. When compared with women without endometriosis, the median anti‐Müllerian hormone (AMH) and antral follicular count (AFC) values were significantly lower in the group of women with endometriosis—median 2.1 ng/ml (interquartile range [IQR] 1.1–3.9) versus 1.2 ng/ml (IQR 0.6–2.4; P < 0.001) for AMH and 14 follicles (IQR 8–23) versus 7 follicles (IQR 5–14; P < 0.001) for AFC. When stratified into two age groups the association between a lower AFC and endometriosis remained significant for both age groups whereas the association between a lower AMH and endometriosis was significant only for the group of women aged 35 years oor older.ConclusionOur study highlights a detrimental effect by endometriosis and an age enhancement effect of endometriosis on ovarian reserve.
Evaluation of sexual violence among lesbian, bisexual, and heterosexual Hispanic women living in Puerto Rico
Authors: García‐Crescioni Keyla , Frontera‐Hernández Mariana , Roura‐Monllor Jaime , Romaguera Josefina 
Published: October 2022

AbstractObjectiveTo investigate the association between sexual orientation and sexual violence in Hispanic women living in Puerto Rico.MethodsSecondary data analysis of a cross‐sectional study. An anonymous web‐based questionnaire was distributed in Puerto Rico between February and April 2016. Variables included history of sexual violence, sexual orientation, and age of first sexual experiences. Data were analyzed using χ2 testing and a P value less than 0.05 was considered significant.ResultsSociodemographic characteristics were similar between groups except for age in the 476 participants. The most common age of first sexual experiences was between 7 and 12 years, 13–18 years for penile vaginal and oral sex, and 22–29 years for penile anal sex in the overall population of the study. These did not differ except that more bisexual women 40 (71.4%) had their first oral sex experience at 13–18 years compared with 164 (50.7%) heterosexual and 35 (55.2%) lesbian women (P = 0.045). Of the 19.2% of participants who reported sexual violence, there were 50 (18.4%) heterosexual, 8 (12.2%) lesbian, and 17 (34.7%) bisexual women. Bisexual women were more likely to disclose sexual violence (P = 0.007).ConclusionMost women stated having a sexual experience at a young age. Significant proportions reported sexual violence with bisexual women being the most likely. Screening for sexual violence must be routinely performed by health professionals.
Adaptation of cardiomyogenesis to the generation and maturation of cardiomyocytes from human pluripotent stem cells
Authors: Martyniak Alicja , Jeż Mateusz , Dulak Józef , Stępniewski Jacek 
Published: October 2022

AbstractThe advent of methods for efficient generation and cardiac differentiation of pluripotent stem cells opened new avenues for disease modelling, drug testing, and cell therapies of the heart. However, cardiomyocytes (CM) obtained from such cells demonstrate an immature, foetal‐like phenotype that involves spontaneous contractions, irregular morphology, expression of embryonic isoforms of sarcomere components, and low level of ion channels. These and other features may affect cellular response to putative therapeutic compounds and the efficient integration into the host myocardium after in vivo delivery. Therefore, novel strategies to increase the maturity of pluripotent stem cell‐derived CM are of utmost importance. Several approaches have already been developed relying on molecular changes that occur during foetal and postnatal maturation of the heart, its electromechanical activity, and the cellular composition. As a better understanding of these determinants may facilitate the generation of efficient protocols for in vitro acquisition of an adult‐like phenotype by immature CM, this review summarizes the most important molecular factors that govern CM during embryonic development, postnatal changes that trigger heart maturation, as well as protocols that are currently used to generate mature pluripotent stem cell‐derived cardiomyocytes.