bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS PENGARUH SUMBER DAYA MANUSIA, PARTISIPASI PENYUSUNAN ANGGARAN, DAN PENYUSUNAN ANGGARAN TERHADAP SISTEM MANAJEMEN AKUNTANSI PENGELOLAAN KEUANGAN DESA MELALUI BMPD TIMOR TENGAH SELATAN
Authors: Se'u Dedy Raidons , Djawang Jofret Umbu Soru Peku 
Published: April 2022

Research is focused to analyze the influence of human resources, participation in the preparation of the budget, and the preparation of the budget Toward Financial Management Accounting Management system of village in South Central Timor Regency, East Nusa Tenggara province. This research was conducted because the village Government apparatus in the financial management of the village has not been in accordance with the applicable provisions. This research is expected to be beneficial to the Government of the village of South Central Timor Regency province of East Nusa Tenggara (NTT) in an attempt to improve the financial management of the village is effectively and efficiently in order to improve the performance of the apparatus of Government village in South Central Timor Regency. Research conducted in six villages that existed in South Central Timor Regency implementing financial management as the location of the village. Data sources are some of the apparatus of Government, composed of the head of the village, the village Secretary, Financial Development, Kasie Kaur, and Kasie Kesra. Research done by disseminating a questionnaire in the form of a statement for the content and manner of doing observations about the financial management of the village. The results showed that for the planning and execution of the financial management of the village, already revealed the existence of a Village financial management accountable and transparent, but the Administration is still required the existence of a coaching more, because not yet fully comply with the provisions. The main obstacle is not yet effectively coaching apparatus of Government and the competence of human resources are adequate, so still need coaching and mentoring from BPMPD as local government authorities on an ongoing basis.
Upaya Meningkatkan Kemampuan Berpikir Kritis Matematika dengan Materi Himpunan Melalui Model Pembelajaran Kooperatif Tipe Numbered Head Together (NHT) pada Siswa Kelas VII SMP Satap Negeri Nian
Authors: Aek Agustina , Nur Ahzan Zulkaidah , Suddin Sulasri 
Published: April 2022

Tujuan penelitian ini untuk meningkatkan kemampuan berpikir kritis matematika siswa kelas VIIA SMP Satap Negeri Nian dengan menggunakan model pembelajaran kooperatif tipe NHT (Numbered Heads Together). Penelitian ini dilakukan di SMP Satap Negeri Nian tahun ajaran 2021/2022. Penelitian ini adalah penelitian tindakan kelas dengan beberapa tahap penelitian yaitu perencanaan (plan), tindakan (act), pengamatan (observe) dan refleksi (reflect). Dengan subjek penelitian adalah siswa kelas VIIA SMP Satap Negeri Nian yang berjumlah 21 siswa. Objek dalam penelitian ini adalah penerapan model pembelajaran kooperatif tipe Numbered Head Together (NHT). Instrumen yang digunakan adalah lembar observasi keterlaksanaan pembelajaran, tes kemampuan berpikir kritis matematika siswa. Teknik analisis data dengan menghitung rata – rata nilai observasi dengan menggategori tingkat kemampuan berpikir kritis siswa berdasarkan klasifikasi kemampuan berpikir kritis. Hasil penelitian menunjukan bahwa model pembelajaran kooperatif tipe Numbered Head Together (NHT) dapat meningkatkan kemampuan berpikir kritis siswa kelas VIIA SMP Satap Negeri Nian. Data hasil penelitian yang diperoleh dari siklus I dan siklus II menggambarkan bahwa ada peningkatan berpikir kritis siswa dari siklus I ke siklus II. Hal ini terbukti dari siklus I jumlah siswa yang tuntas sebanyak 13 orang meningkat pada siklus II menjadi 16 orang. Persentase ketuntasan kelas pada siklus I sebesar 61,90% meningkat sebesar 14,28% menjadi 76,19% pada siklus II.
Physical Activity, Outdoor and Adventure Sports During the Covid-19 Pandemic Process
Authors: Gürer Burak , Biçer Mürsel 
Published: April 2022

The COVID-19 pandemic has created unprecedented chaos worldwide in the current century. Thousands of people died, and millions of people caught the COVID-19 virus. In this tough time, people locked themselves down in their homes for a long time, either voluntarily or mandatorily as part of governmental precautions against the rapid spreading of the virus. This difficult time forced people to change their daily life routines to a sedentary life which affected them mentally and psychologically. Following the lifting of the restrictions, people have started to make an intense effort to do physical activity and spend more time in nature to relax. Consequently, physical activity in a safe environment has become a priority for most people. With this challenging period, open spaces have become more preferred areas for physical activity rather than closed areas. Outdoor and adventure sports have started to consider the safest way of physical activity. Intense physical activity can be done in outdoor and adventure sports, depending on the type of activities. With the necessary precautions taken during the activities, doing outdoor and adventure sports has become a critical step in reducing the effects of mental and psychological factors such as stress, pessimism, bad mood, and unhappiness. Moreover, these sports physically contribute positively to lung capacity. This study provides useful information about outdoor and adventure sports along with highlighting important points and possible risks when doing physical activity in open spaces during the COVID-19 pandemic.

Keywords: adventure sports, COVID-19, physical activity, outdoor sports.
A Cell-free Expression Pipeline for the Generation and Functional Characterization of Nanobodies
Authors: Haueis Lisa , Stech Marlitt , Kubick Stefan 
Published: April 2022

Cell-free systems are well-established platforms for the rapid synthesis, screening, engineering and modification of all kinds of recombinant proteins ranging from membrane proteins to soluble proteins, enzymes and even toxins. Also within the antibody field the cell-free technology has gained considerable attention with respect to the clinical research pipeline including antibody discovery and production. Besides the classical full-length monoclonal antibodies (mAbs), so-called “nanobodies” (Nbs) have come into focus. A Nb is the smallest naturally-derived functional antibody fragment known and represents the variable domain (VHH, ∼15 kDa) of a camelid heavy-chain-only antibody (HCAb). Based on their nanoscale and their special structure, Nbs display striking advantages concerning their production, but also their characteristics as binders, such as high stability, diversity, improved tissue penetration and reaching of cavity-like epitopes. The classical way to produce Nbs depends on the use of living cells as production host. Though cell-based production is well-established, it is still time-consuming, laborious and hardly amenable for high-throughput applications. Here, we present for the first time to our knowledge the synthesis of functional Nbs in a standardized mammalian cell-free system based on Chinese hamster ovary (CHO) cell lysates. Cell-free reactions were shown to be time-efficient and easy-to-handle allowing for the “on demand” synthesis of Nbs. Taken together, we complement available methods and demonstrate a promising new system for Nb selection and validation.
Diagnostic Value of Delayed Contrast-Enhanced Cardiac Computed Tomography for Detecting Left Atrial Appendage Thrombus in Patients With Atrial Fibrillation
Authors: Li Xiang-Nan , Wang Jing-Xi , Wei Qing , Yu Xian-Bo , Zhou Yu-Tao , Ma Xiao-Yan , Zhao Na , Lu Bin 
Published: April 2022

ObjectiveDelayed enhancement cardiac CT is a reliable tool for the diagnosis of left atrial appendage thrombus but limited for scanning heterogeneity. We aimed to explore the improvement of the 1 and 3-min delay phase at the diagnostic level to detect left atrial appendage thrombus, in order to set up a reasonable CT scanning scheme.Materials and MethodsA total of 6,524 patients were continuously retrieved from January 2015 to September 2020 retrospectively. The patients had undergone Transesophageal echocardiography (TEE) and cardiac CT with complete period include the arterial enhancement phase, 1 and 3-min delay phase, TEE were used as the reference standard. The final study included 329 patients. Three experienced radiologists independently assessed each phase of the cardiac CT images for thrombus diagnosis. We explored the improvement of the diagnostic ability of different delayed contrast-enhanced phases for left atrial appendage thrombus detection. Multiple logistic regression analysis were used for further high-risk stratification to avoid an additional 1-min delayed scan.ResultsIn total, 29 thrombosis were detected at TEE. For all cardiac CT phases, sensitivity and negative predictive were 100%. The specificity were 0.54, 0.93, and 1.00, respectively; The positive predictive values (PPV) were 0.17, 0.57, and 1.00, respectively; Area under curve (AUC) were 0.75, 0.95, and 0.98, respectively. High risk factors that cannot be clearly diagnosed with 1-min delay phase included reduced cardiac function, increased CHA2DS2-VAScscore and left atrial enlargement. Compared with the arterial enhanced phase, increased radiation doses in the 1 and 3-min delay phases were 1.7 ± 1.3 msv and 1.5 ± 0.8 msv (mean ± standard deviation).ConclusionUsing TEE as the reference standard, early contrast-enhanced CT scanning with 1 and 3-min delay is necessary for the diagnosis of left appendage thrombus, which could significantly improve the diagnostic efficiency. Patients with high-risk stratification are suitable for direct 3-min delayed scanning.
Knowledge Mapping of the Links Between the Gut Microbiota and Heart Failure: A Scientometric Investigation (2006–2021)
Authors: Mu Fei , Tang Meng , Guan Yue , Lin Rui , Zhao Meina , Zhao Jiaxin , Huang Shaojie , Zhang Haiyue , Wang Jingwen , Tang Haifeng 
Published: April 2022

BackgroundThere is considerable research value and extensive application perspectives to explore the link between gut microbiota and heart failure. The purpose of this study is to provide an overview of overall characteristics, evolutionary pathways, frontier research hotspots, and future trends in this field.MethodsResearch datasets were acquired from the Web of Science Core Collection (WoSCC) between January 1, 2006 and December 31, 2021. Three different analysis tools including one online platform, VOS viewer V1.6.17.0, and CiteSpace V5.8.R2 software were used in order to conduct collaboration network analysis, co-cited analysis, co-occurring analysis, and citation burst detection.ResultsA total of 873 publications in the WoSCC database met the requirement. The overall characteristics analysis showed that a steady growth trend in the number of publications and citations, with the predominant literature type being articles and the most frequent subject category being cardiac cardiovascular systems. The United States was the most prolific country and the center of national collaboration. Cleveland Clinic and Nathalie M. Delzenne provided the leading influence with publications, the cooperation between the institutes and authors were relatively weak. Moreover, gut microbiota, heart failure, risk factor, obesity, and inflammation were the keywords that appeared more frequently in the clustering analysis of reference co-citation and keyword co-occurrence. Burst detection analysis of top keywords showed that trimethylamine N-oxide (TMAO), bile acid, blood pressure, hypertension, and fermentation were the new research foci on the association between gut microbiota and heart failure. Strategies to improve gut microbiota hold promise as a new approach to treat heart failure.ConclusionThe comprehensive bibliometric study indicates that the structured information may be helpful in understanding research trends in the link between gut microbiota and heart failure, and locating research hotspots and gaps in this domain, especially further advances in this field will lead to significant breakthroughs in the development of novel therapeutic tools for metabolic modulation of heart failure.
Taxonomic and Functional Fecal Microbiota Signatures Associated With Insulin Resistance in Non-Diabetic Subjects With Overweight/Obesity Within the Frame of the PREDIMED-Plus Study
Authors: Atzeni Alessandro , Bastiaanssen Thomaz F. S. , Cryan John F. , Tinahones Francisco J. , Vioque Jesús , Corella Dolores , Fitó Montserrat , Vidal Josep , Moreno-Indias Isabel , Gómez-Pérez Ana M. , Torres-Collado Laura , Coltell Oscar , Castañer Olga , Bulló Monica , Salas-Salvadó Jordi 
Published: April 2022

ObjectiveAn altered gut microbiota has been associated with insulin resistance, a metabolic dysfunction consisting of cellular insulin signaling impairment. The aim of the present study is to determine the taxonomic and functional fecal microbiota signatures associated with HOMA-IR index in a population with high cardiovascular risk.MethodsA total of 279 non-diabetic individuals (55–75 years aged) with overweight/obesity and metabolic syndrome were stratified according to tertiles of HOMA-IR index. Blood biochemical parameters, anthropometric measurements and fecal samples were collected at baseline. Fecal microbial DNA extraction, 16S amplicon sequencing and bioinformatics analysis were performed.ResultsDesulfovibrio, Odoribacter and Oscillospiraceae UCG-002 were negatively associated with HOMA-IR index, whereas predicted total functional abundances revealed gut metabolic modules mainly linked to amino acid degradation. Butyricicoccus, Erysipelotrichaceae UCG-003, Faecalibacterium were positively associated with HOMA-IR index, whereas predicted total functional abundances revealed gut metabolic modules mainly linked to saccharide degradation. These bacteria contribute differentially to the gut metabolic modules, being the degree of contribution dependent on insulin resistance. Both taxa and gut metabolic modules negatively associated to HOMA-IR index were linked to mechanisms involving sulfate reducing bacteria, improvement of intestinal gluconeogenesis and production of acetate. Furthermore, both taxa and gut metabolic modules positively associated to HOMA-IR index were linked to production and mechanisms of action of butyrate.ConclusionsSpecific taxonomic and functional fecal microbiota signatures associated with insulin resistance were identified in a non-diabetic population with overweight/obesity at high cardiovascular risk. These findings suggest that tailoring therapies based on specific fecal microbiota profiles could be a potential strategy to improve insulin sensitivity.
The Evaluation of Ovarian Function Recovery Following Treatment of Primary Ovarian Insufficiency: A Systematic Review
Authors: Kuang Xiaojun , Tang Yongzhe , Xu Hong , Ji Min , Lai Dongmei 
Published: April 2022

BackgroundPrimary ovarian insufficiency (POI) is gaining awareness as its prevalence increases and its effect on patients is extremely negative. To date, several therapies have been designed to treat POI, but the conclusions are conflicting, in part, due to inconsistent evaluation methods. Thus, we explore a multi-index of ovarian function assessment methods to evaluate the recovery of ovarian function after various therapies in order to evaluate effectiveness in a more comprehensive manner.AimThe purpose of this review is to assess the effectiveness of various therapies to recover ovarian function in patients with POI. The primary outcome measures were anti-Müllerian hormone (AMH) levels, follicle stimulating hormone (FSH) levels, and antral follicle count (AFC). The secondary outcomes included the change of mean ovarian volume, menstruation recovery, and pregnancy rate.MethodsOur systematic searching including PubMed, Web of Science, Cochrane, and Embase databases was conducted to find all human clinical trial articles published from January 2000 to April 2021 and related to POI treatment, including the keywords: POI, AFC, and hormones. All prospective and retrospective studies exploring ovarian function recovery that include AFC, AMH levels, and FSH levels evolution throughout treatment were included. All patients included in the studies met the POI criteria described by the European Society for Human Reproductive Embryology (ESHRE) guideline.ResultsSix studies were selected based on the criteria: one randomized controlled trial and five observational studies. Among them, two studies focused on the intraovarian platelet-rich plasma (PRP) infusion treatment, two studies focused on dehydroepiandrosterone (DHEA) supplements, one study focused on hormone replacement therapy (HRT), and one study focused on autologous adipose-derived stromal cells (ADSCs) treatment. There was insufficient scientific evidence that any approach could help ovarian function recovery in patients with POI because the ovarian function markers in each study had inconsistent changes with 26 patients (6.2%) reporting spontaneous pregnancy.ConclusionSerum AMH levels, FSH levels, and AFC are sensitive indicators and reflect the evolution of ovarian function. Large randomized controlled trials are necessary, and the data on ovarian function should be collected comprehensively to evaluate the effectiveness of a variety of treatments.
The Anti-Inflammatory and Free Radical Scavenging Activities of Bio-Inspired Nano Magnesium Oxide
Authors: Shahid Sammia , Ejaz Anam , Javed Mohsin , Mansoor Sana , Iqbal Shahid , Elkaeed Eslam B. , Alzhrani Rami M. , Alsaab Hashem O. , Awwad Nasser S. , Ibrahium Hala A. , Fatima Urooj , Zaman Sabah , Nazim Sarwar Muhammad 
Published: April 2022

This work includes green synthesis of magnesium oxide nanoparticles (MgO NPs) by using Alstoniascholaris, which is indigenous to many countries such as China, Australia, Sri Lanka, Pakistan, and India. Its pharmacological activities include antidiabetic, antioxidant, anticancer, analgesic, antitussive, and anti-diarrheal activities. In this study, the antioxidant and anti-inflammatory activities of bio-inspired magnesium oxide nanoparticles, MgO NPs, were investigated. MgO NPs were prepared by using the leaf extract of Alstonia scholaris, followed by characterization using EDX, XRD, and SEM techniques. The crystallite size of magnesium oxide nanoparticles was 19.57 nm. XRD analysis confirmed the crystallinity and the purity of MgO NPs. Anti-inflammatory activity was carried out to observe inhibition of protein denaturation. Since the IC50 of MgO nanoparticles was lower than the standard, it was found to be more effective. IC50 values were compared, and results reveal that bioinspired MgO NPs undergo more scavenging of free radicals than standard (ascorbic acid) MgO NPs. These MgO nanoparticles are useful in cosmetics such as scrubs, moisturizers, and an active ingredient in microdermabrasion and in formulating effective drugs for maintaining the protein structure of the body, which will reduce inflammation.
Strong Perpendicular Anisotropy and Anisotropic Landé Factor in Bismuth-Doped Thulium Garnet Thin Films
Authors: Zhang Xiuye , Jin Lichuan , Zhang Dainan , Liu Bo , Meng Hao , Zhang Lei , Zhong Zhiyong , Tang Xiaoli 
Published: April 2022

With the development of spintronics, garnet films with perpendicular magnetic anisotropy (PMA) have been attracting the attention of researchers for decades. In this work, bismuth-doped thulium iron garnet (Tm2BiFe5O12, TmBiIG) films of varying thickness having strong PMA effect were fabricated on substituted Gd3Ga5O12 (sGGG) (111) substrates using the pulsed laser deposition (PLD) technique. Crystallographic characterization and magnetic properties of TmBiIG films were investigated using high-resolution scanning transmission electron microscopy, X-ray diffraction, vibrating sample magnetometry, and broadband ferromagnetic resonance (FMR). A high perpendicular anisotropic field of H⊥ = 4,445 ± 7.5 Oe in a 10-nm-thick film and H⊥ = 4,582 ± 7.7 Oe in a 30-nm-thick film at room temperature were obtained and analyzed in detail. Surprisingly, an additional spin-wave mode was observed in the in-plane FMR spectra. The discrepancy between in-plane and the out-of-plane Landé g-factors established a correlation with the PMA effect in the TmBiIG films. The Landé g-factor of the TmBiIG films is much lower than that of free electrons, indicating that the strong spin–orbit coupling is caused by Tm and Bi heavy elements. The Gilbert damping factor α changed from 0.007 to 0.012 in various thicknesses of TmBiIG films.
Zintl Phase Compounds Mg3Sb2−xBix (x = 0, 1, and 2) Monolayers: Electronic, Phonon and Thermoelectric Properties From ab Initio Calculations
Authors: Chang Zheng , Ma Jing , Yuan Kunpeng , Zheng Jiongzhi , Wei Bin , Al-Fahdi Mohammed , Gao Yufei , Zhang Xiaoliang , Shao Hezhu , Hu Ming , Tang Dawei 
Published: April 2022

The Mg3Sb2−xBix family has emerged as the potential candidates for thermoelectric applications due to their ultra-low lattice thermal conductivity (κL) at room temperature (RT) and structural complexity. Here, using ab initio calculations of the electron-phonon averaged (EPA) approximation coupled with Boltzmann transport equation (BTE), we have studied electronic, phonon and thermoelectric properties of Mg3Sb2−xBix (x = 0, 1, and 2) monolayers. In violation of common mass-trend expectations, increasing Bi element content with heavier Zintl phase compounds yields an abnormal change in κL in two-dimensional Mg3Sb2−xBix crystals at RT (∼0.51, 1.86, and 0.25 W/mK for Mg3Sb2, Mg3SbBi, and Mg3Bi2). The κL trend was detailedly analyzed via the phonon heat capacity, group velocity and lifetime parameters. Based on quantitative electronic band structures, the electronic bonding through the crystal orbital Hamilton population (COHP) and electron local function analysis we reveal the underlying mechanism for the semiconductor-semimetallic transition of Mg3Sb2-−xBix compounds, and these electronic transport properties (Seebeck coefficient, electrical conductivity, and electronic thermal conductivity) were calculated. We demonstrate that the highest dimensionless figure of merit ZT of Mg3Sb2−xBix compounds with increasing Bi content can reach ∼1.6, 0.2, and 0.6 at 700 K, respectively. Our results can indicate that replacing heavier anion element in Zintl phase Mg3Sb2−xBix materials go beyond common expectations (a heavier atom always lead to a lower κL from Slack’s theory), which provide a novel insight for regulating thermoelectric performance without restricting conventional heavy atomic mass approach.