bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mediating Role of Lifestyle Behaviors in the Association between Education and Cancer: Results from the European Prospective Investigation into Cancer and Nutrition
Authors: Macciotta Alessandra , Catalano Alberto , Giraudo Maria Teresa , Weiderpass Elisabete , Ferrari Pietro , Freisling Heinz , Colorado-Yohar Sandra M. , Santiuste Carmen , Amiano Pilar , Heath Alicia K. , Ward Heather A. , Christakoudi Sofia , Vineis Paolo , Singh Deependra , Vaccarella Salvatore , Schulze Matthias B. , Hiensch Anouk E. , Monninkhof Evelyn M. , Katzke Verena , Kaaks Rudolf , Tumino Rosario , Lazzarato Fulvio , Milani Lorenzo , Agudo Antonio , Dahm Christina C. , Baglietto Laura , Perduca Vittorio , Severi Gianluca , Grioni Sara , Panico Salvatore , Ardanaz Eva , Borch Kristin B. , Benebo Faith O. , Braaten Tonje , Sánchez Maria-Jose , Giachino Claudia , Sacerdote Carlotta , Ricceri Fulvio 
Published: October 2022

Abstract

Background:
Many studies have shown that socioeconomic position (SEP) is associated with the incidence of malignant tumors at different sites. This study aims to estimate the association between educational level (as proxy for SEP) and cancer incidence and to understand whether the observed associations might be partially explained by lifestyle behaviors.

Methods:
The analyses were performed on data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study, globally and by sex. We used Cox proportional hazards models together with mediation analysis to disentangle the total effect (TE) of educational level [measured through the Relative Index of Inequality (RII)] on cancer incidence into pure direct (PDE) and total indirect (TIE) effect, unexplained and explained by mediators, respectively. PDE and TIE were then combined to compute the proportions mediated (PM).

Results:
After an average of 14 years of follow-up, 52,422 malignant tumors were ascertained. Low educated participants showed higher risk of developing stomach, lung, kidney (in women), and bladder (in men) cancers, and, conversely, lower risk of melanoma and breast cancer (in post-menopausal women), when compared with more educated participants. Mediation analyses showed that portions of the TE of RII on cancer could be explained by site-specific related lifestyle behaviors for stomach, lung, and breast (in women).

Conclusions:
Cancer incidence in Europe is determined at least in part by a socioeconomically stratified distribution of risk factors.

Impact:
These observational findings support policies to reduce cancer occurrence by altering mediators, such as lifestyle behaviors, particularly focusing on underprivileged strata of the population.
Epigenome Programming by H3.3K27M Mutation Creates a Dependence of Pediatric Glioma on SMARCA4
Authors: Mo Yan , Duan Shoufu , Zhang Xu , Hua Xu , Zhou Hui , Wei Hong-Jian , Watanabe Jun , McQuillan Nicholas , Su Zhenyi , Gu Wei , Wu Cheng-Chia , Vakoc Christopher R. , Hashizume Rintaro , Chang Kenneth , Zhang Zhiguo 
Published: October 2022

Abstract

Patients with diffuse midline gliomas that are H3K27 altered (DMG) display a dismal prognosis. However, the molecular mechanisms underlying DMG tumorigenesis remain poorly defined. Here we show that SMARCA4, the catalytic subunit of the mammalian SWI/SNF chromatin remodeling complex, is essential for the proliferation, migration, and invasion of DMG cells and tumor growth in patient-derived DMG xenograft models. SMARCA4 colocalizes with SOX10 at gene regulatory elements to control the expression of genes involved in cell growth and the extracellular matrix (ECM). Moreover, SMARCA4 chromatin binding is reduced upon depletion of SOX10 or H3.3K27M, a mutation occurring in about 60% DMG tumors. Furthermore, the SMARCA4 occupancy at enhancers marked by both SOX10 and H3K27 acetylation is reduced the most upon depleting the H3.3K27M mutation. Taken together, our results support a model in which epigenome reprogramming by H3.3K27M creates a dependence on SMARCA4-mediated chromatin remodeling to drive gene expression and the pathogenesis of H3.3K27M DMG.

Significance:
DMG is a deadly pediatric glioma currently without effective treatments. We discovered that the chromatin remodeler SMARCA4 is essential for the proliferation of DMG with H3K27M mutation in vitro and in vivo, identifying a potentially novel therapeutic approach to this disease.
See related commentary by Beytagh and Weiss, p. 2730.
See related article by Panditharatna et al., p. 2880.
This article is highlighted in the In This Issue feature, p. 2711
The Dynamic Relationship Between Invasive Microvascular Function and Microvascular Injury Indicators, and Their Association With Left Ventricular Function and Infarct Size at 1-Month After Reperfused ST-Segment–Elevation Myocardial Infarction
Authors: Demirkiran Ahmet , Robbers Lourens F.H.J. , van der Hoeven Nina W. , Everaars Henk , Hopman Luuk H.G.A. , Janssens Gladys N. , Berkhof Hans J. , Lemkes Jorrit S. , van de Bovenkamp Arno A. , van Leeuwen Maarten A.H. , Nap Alexander , van Loon Ramon B. , de Waard Guus A. , van Rossum Albert C. , van Royen Niels , Nijveldt Robin 
Published: October 2022

Background:
The invasive microvascular function indices, coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR), exhibit a dynamic pattern after ST-segment–elevation myocardial infarction. The effects of microvascular injury on the evolution of the microvascular function and the prognostic significance of the evolution of microvascular function are unknown. We investigated the relationship between the temporal changes of CFR and IMR, and cardiovascular magnetic resonance-derived microvascular injury characteristics in reperfused ST-segment–elevation myocardial infarction patients, and their association with 1-month left ventricular ejection fraction and infarct size (IS).

Methods:
In 109 ST-segment–elevation myocardial infarction patients who underwent angiography for primary percutaneous coronary intervention (PPCI) and at 1-month follow-up, invasive assessment of CFR and IMR were performed in the culprit artery during both procedures. Cardiovascular magnetic resonance was performed 2 to 7 days after PPCI and at 1 month and provided assessment of left ventricular ejection fraction, IS, microvascular obstruction, and intramyocardial hemorrhage.

Results:

CFR and IMR significantly changed over 1 month (both,
P
<0.001). The absolute IMR change over 1 month (ΔIMR) showed association with both microvascular obstruction and intramyocardial hemorrhage presence (both,
P
=0.01). ΔIMR differed between patients with/without microvascular obstruction (
P
=0.02) and with/without intramyocardial hemorrhage (
P
=0.04) but not ΔCFR for both. ΔIMR demonstrated association with both left ventricular ejection fraction and IS at 1 month (
P
<0.001,
P
=0.001, respectively), but not ΔCFR for both. Receiver-operating characteristics curve analysis of ΔIMR showed a larger area under the curve than post-PPCI CFR and IMR, and ΔCFR to be associated with both 1-month left ventricular ejection fraction >50% and extensive IS (the highest quartile).

Conclusions:
In reperfused ST-segment–elevation myocardial infarction patients, CFR and IMR significantly improved 1 month after PPCI; the temporal change in IMR is closely related to the presence/absence of microvascular damage and IS. ΔIMR exhibits a stronger association for 1-month functional outcome than post-PPCI CFR, IMR, or ΔCFR.
The Human in Feminist Theory: Or Woman Is a Social Animal, I’m Not So Sure About Man
Authors: Green Karen 
Published: October 2022

Abstract
A feminist humanism, unlike those developed by men, would recognize that the authoritative, human subject comes in two sexes. While not being essentialist, it would accept the existence of biological, sexual difference, while taking seriously historical and cultural diversity. It would find female subjects, not in their bodies, but in their contributions to intellectual history. To defend this feminist humanism, this paper counters the post-structuralist critique of humanism, criticizing the structuralist account of language on which post-structuralism built, which it retained even in going beyond it. At the same time, it repurposes the Foucauldian idea of an archeology of knowledge to propose a feminist humanism, anchored in an archeology of women’s texts. It claims that the findings of the archeological investigations so far undertaken suggest that while man characteristically deems himself an isolated individual, made social by culture and artifice, woman, in general, experiences herself as social by nature.
Upper–Lower Layer Coupling of Recurrent Circulation Patterns in the Gulf of Mexico
Authors: Olvera-Prado Erick R. , Moreles Efraín , Zavala-Hidalgo Jorge , Romero-Centeno Rosario 
Published: October 2022

Abstract
The study of the relationship between the upper and lower layers in the Gulf of Mexico (GoM) has experienced a lot of progress in recent years. Nevertheless, an examination of their coupling for the entire GoM in a statistically consistent manner is still needed. Layer thickness data from a GoM 21-yr free-running simulation are used to examine the coupling between the upper (<250 m) and lower (>1000 m) layers, focusing on the dominant modes of variability through a Hilbert empirical orthogonal function (HEOF) analysis. The results show that the three leading modes are associated with the coupling between both layers during the life cycle of the Loop Current (LC) and the LC eddy (LCE) separation process, consistent with previous observational studies. These modes are cyclical, with periodicities in agreement with the mean LCE separation period, indicating recurrence of the circulation patterns. The fourth mode of the upper layer is associated with the translation of LCEs and their dissipation in the northwestern GoM, while in the lower layer it captures variability related to the strengthening of the circulation along the Sigsbee Gyre western branch. This mode does not show cyclicity, suggesting persistence of the associated circulation patterns with a dominant time scale of 14 months. Evidence and corroboration of recently observed lower-layer circulation features are provided. The application of the HEOF technique used here can complement the three-dimensional oceanic assimilation methods by projecting surface information to depth in a statistically consistent manner.

Significance Statement
The purpose of this study is to better understand the relationship between the upper and lower ocean layers in the Gulf of Mexico. While much is known about their variability separately, an examination of the coupling through the whole region and in a long time period is still needed. We use a free numerical simulation of the circulation in the Gulf to accomplish this goal. The dominant circulation patterns in the lower layer are tied to the upper ones and are governed by the same temporal scales. Our findings point to a way to better understand the response of deep circulation to upper circulation, and may contribute to a better prediction of ocean dynamics.
A protocol for removing environmental barriers to independent living (REBIL): An adapted evidence-based occupational therapy intervention to increase community participation for individuals aging with long-term physical disabilities
Authors: Chen Szu-Wei , Somerville Emily , Devine Megen , Stark Susan 
Published: October 2022

Background:People aging with long-term physical disabilities are living longer and experiencing the challenges of aging, including the onset of secondary and age-related health conditions. People aging with long-term physical disabilities are at high risk of falls, fall injuries, diminished functional abilities, and compromised participation. However, no available programs support people aging with long-term physical disabilities to participate safely at home and in the community. The proposed study is to examine the feasibility and efficacy of an adapted intervention: removing environmental barriers to independent living.Method/Design:A single-blinded randomized controlled trial will be conducted. Participants who are 45–65 years old; self-report difficulty with ⩾2 daily activities; have had a physical disability for ⩾5 years; and live within 60 mi of the research lab are eligible. All participants will receive an initial in-home evaluation before randomization. The treatment group will receive removing environmental barriers to independent living (total five visits) intervention, which is tailored. The waitlist control group will be offered the same intervention after 6-month follow-up. Expected outcomes are high acceptability, fidelity, and adherence; low safety risk; improved community participation and daily activities performance; and fewer environmental barriers and fall hazards.Discussion:Findings will serve as preliminary evidence for occupational therapy community practice. Outcomes will also inform future large, pragmatic trials. Trial Registration: ClinicalTrials.gov identifier NCT04589988
Team Members Show Decreased Inter-brain Coupling When Resolving Uncertainty
Authors: Stevens Ronald , Galloway Trysha 
Published: October 2022

Team members regulate their activities and move together at the collective level of behavior while coordinating their actions toward shared goals. In parallel with team processes, team members need to resolve uncertainties arising from their changing task work and a shifting environment. We explored the neurodynamic tension between resolving individual uncertainty and participating in collaborative processes during high fidelity team training. Electroencephalography (EEG) was collected from five two-person medical flight teams and following pre-processing to remove non-brain signals, the inter-brain coherence ( IBC) were estimated by wavelet coherence and compared with the neurodynamic information ( NI) of each individual, a measure that maps closely with human uncertainty. Analysis of the second-by-second IBC and NI showed that the expressions of NI and IBC were not simultaneous and may be mutually exclusive, suggesting that the factors elevating and resolving NI levels are single person processes and that it may be difficult for team members to maintain IBC while reducing their uncertainties. Although preliminary, these studies provide a first step towards neurodynamically quantifying and modifying teamwork and task work processes.
Impact of Monitoring Requests on Trust, Acceptance, Blame, and Praise of Autonomous Vehicles
Authors: Kettle Liam , Lee Yi-Ching 
Published: October 2022

Vehicles with autonomous features are more prevalent in today’s society, though as the level of autonomation increases, so does the vehicle system’s control of the vehicle. As the driving control shifts from human to the vehicle system, concerns arise regarding the attribution of responsibility and blame following critical events (e.g., collisions or near-misses). In this work-in-progress study, we aim to understand how the public attributes blame and praise to both humans and autonomous vehicles (AVs) following critical events. In addition, we examine how an AI driving assistant that administers Monitoring Requests influences blame and praise attributions. Furthermore, we examine differences in acceptance, trust, and perceived anthropomorphism between an AV with and without an AI driving assistant. Preliminary results are provided followed by a discussion of the expected results and potential impact for research and legal issues.
Ventilation Efficiency According to Tilt Angle to Reduce the Transmission of Infectious Disease in Classroom
Authors: Chung Ji Hong , Kim Sunuk , Sohn Dong Kee , Ko Han Seo 
Published: October 2022

Understanding of the droplet transmission of respiratory diseases is necessary to control the outbreak of COVID-19. HVAC systems considering droplet transmission are commonly used to prevent numerous respiratory diseases by reducing indoor virus concentrations. The transmission of the virus was directly related to indoor flow patterns generated by HVAC systems. Thus, a study on operating conditions such as direction or the tilt angle was required. In this study, the effective ventilation rate and probability of droplet transmission according to the tilt angle of supply air and the number of people were studied. A CO2 tracer gas method was used to validate the results of simulations. The breathing plane and personal respiratory zone were introduced for the probability of droplet transmission. The result showed that ventilation performance showed 17% of the maximum difference among tilt angles. Various turbulent kinetic energies were obtained according to the seated positions, resulting in non-uniform CO2 concentration. Numerous conditions were examined with locational analysis of individuals. As a result, the flow rates for ventilation were recommended to be higher than 250 m3/h and 350 m3/h with a tilt angle of 60° for an occupancy of 8 and 16 people, respectively.
Models of care for improving health-related quality of life, mental health, or mortality in persons with multimorbidity: A systematic review of randomized controlled trials
Authors: Eriksen Christian U , Kamstrup–Larsen Nina , Birke Hanne , Helding Sofie A L , Ghith Nermin , Andersen John S , Frølich Anne 
Published: October 2022

Objectives To categorize and examine the effectiveness regarding health-related quality of life (HRQoL), mental health, and mortality of care models for persons with multimorbidity in primary care, community care, and hospitals through a systematic review. Methods We searched PubMed, Embase, and Cochrane Central Register of Controlled Trials up to May 2020. One author screened titles and abstracts, and to validate, a second author screened 5% of the studies. Two authors independently extracted data and assessed risk of bias using the tool by the Cochrane Effective Practice and Organisation of Care group. Study inclusion criteria were (1) participants aged ≥ 18 years with multimorbidity; (2) referred to multimorbidity or two or more specific chronic conditions in the title or abstract; (3) randomized controlled design; and (4) HRQoL, mental health, or mortality as primary outcome measures. We used the Foundation Framework to categorize the models and the PRISMA-guideline for reporting. Results In this study, the first to report effectiveness of care models in patients with multimorbidity in hospital settings, we included 30 studies and 9,777 participants with multimorbidity. 12 studies were located in primary care, 9 in community care, and 9 in hospitals. HRQoL was reported as the primary outcome in 12 studies, mental health in 17 studies, and mortality in three studies—with significant improvements in 5, 14, and 2, respectively. The studies are presented according to settings. Conclusions Although 20 of the care models reported positive effects, the variations in populations, settings, model elements, and outcome measures made it difficult to conclude on which models and model elements were effective.
Pressure pain threshold and somatosensory abnormalities in different ages and functional conditions of post-stroke elderly
Authors: Zhang Yong-Hui , Xu Hao-Ran , Wang Yu-Chen , Hu Gong-Wei , Ding Xiao-Qin , Shen Xiao-Hua , Yang Hui , Rong Ji-Feng , Wang Xue-Qiang 
Published: October 2022

Abstract
Background
Somatosensory deficits and abnormal pain sensitivity are highly prevalent among stroke survivors, which negatively impacts their quality of life and recovery process. However, the factors for pressure pain threshold (PPT) and somatosensory abnormalities in post-stroke elderly remain unknown. The aim of this study was to explore the effects of age, side and other functional conditions, such as spasticity and motor functions, on PPT and sensory abnormalities among elderly after stroke.

Methods
The cross-sectional study finally included 43 post-stroke elderly aged over 60 and assessed the PPT of 14 bilateral muscles widely located in the whole body by using a digital force gage. Meanwhile, spasticity, motor function, joint pain and activity of daily living (ADL) were evaluated by the Modified Ashworth scale, Fugl-Meyer, and Barthel Index, respectively. All participants were divided into higher-aged and lower-aged groups based on the median age of all of them.

Results
Higher age tended to be associated with higher sensitivity but not significant except for one upper limb muscle, and the affected side showed significantly higher PPTs than the unaffected side in three out of seven muscles (p < 0.05). Furthermore, the somatosensory abnormalities in the affected side, particularly hypoalgesia, were more frequent in higher-aged than lower-aged patients in most assessed muscles. Meanwhile, patients with spasticity showed more increment of PPTs in affected muscles around the knee joint than patients without spasticity (p < 0.05). Patients with better motor functions, less joint pain and higher ADL performed less bilateral differences of PPTs than other patients in some muscles (p < 0.05).

Conclusions
The age and side differences of mechanical pain sensitivity were found among post-stroke elderly. Older patients show higher sensitivity in both sides compared with the younger ones, and the affected side of the elder shows more somatosensory abnormalities, particularly hypoalgesia, than that of the younger ones. Post-stroke elderly in good functional conditions, such as normal muscle tone, better physical function and daily activities, and less joint pain, seems to have more equal pain sensitivity between both sides than those in poor conditions.
A novel stemness-hypoxia-related signature for prognostic stratification and immunotherapy response in hepatocellular carcinoma
Authors: Zhang Genhao , Zhang Kai , Zhao Yanteng , Yang Qiankun , Lv Xianping 
Published: October 2022

Abstract
Background
The specific differentiation potential, unlimited proliferation, and self-renewal capacity of cancer stem cells (CSCs) are closely related to the occurrence, recurrence, and drug resistance of hepatocellular carcinoma (HCC), as well as hypoxia. Therefore, an in-depth analysis of the relationship between HCC stemness, oxygenation status, and the effectiveness of immunotherapy is necessary to improve the poor prognosis of HCC patients.

Methods
The weighted gene co-expression network analysis (WGCNA) was utilized to find hypoxia-related genes, and the stemness index (mRNAsi) was evaluated using the one-class logistic regression (OCLR) technique. Based on stemness-hypoxia-related genes (SHRGs), population subgroup categorization using NMF cluster analysis was carried out. The relationship between SHRGs and survival outcomes was determined using univariate Cox regression. The LASSO-Cox regression strategy was performed to investigate the quality and establish the classifier associated with prognosis. The main effect of risk scores on the tumor microenvironment (TME) and its response to immune checkpoint drugs was also examined. Finally, qRT-PCR was performed to explore the expression and prognostic value of the signature in clinical samples.

Results
After identifying tumor stemness- and hypoxia-related genes through a series of bioinformatics analyses, we constructed a prognostic stratification model based on these SHRGs, which can be effectively applied to the prognostic classification of HCC patients and the prediction of immune checkpoint inhibitors (ICIs) efficacy. Independent validation of the model in the ICGC cohort yielded good results. In addition, we also constructed hypoxic cell models in Herp3B and Huh7 cells to verify the expression of genes in the prognostic model and found that C7, CLEC1B, and CXCL6 were not only related to the tumor stemness but also related to hypoxia. Finally, we found that the constructed signature had a good prognostic value in the clinical sample.

Conclusions
We constructed and validated a stemness-hypoxia-related prognostic signature that can be used to predict the efficacy of ICIs therapy. We also verified that C7, CLEC1B, and CXCL6 are indeed associated with stemness and hypoxia through a hypoxic cell model, which may provide new ideas for individualized immunotherapy.