bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential Role of 8-Hydroxyguanosine and some Pro Inflammatory Cytokines as Biomarkers in Colorectal Cancer Iraqi Patients
Authors: Balaky Hazhar M. 
Published: July 2022

8-hydroxyguanosine (8-OHdG) is considered as an indicator of the oxidative stress. Pro inflammatory cytokines are critical parts of the pathophysiological processes to which treatment can be applied. The aim of this study was to evaluate 8-OHdG and pro inflammatory cytokines concentration in colon carcinoma patients. Blood samples were taken before treatment from 50 incident cases with colon cancer (stage III) admitted for health examination at the Nanakali Hospital in Erbil city with 45 healthy samples of controls with age range between 38-69 years for both groups. All studied parameters were estimated by ELISA. Participants at this study were 95 Participants ranged in age from 38 to 69 years, 50 Participants had been newly diagnosed with colorectal cancer (without treatment) with 45 individuals were healthy used as controls. The data showed a non-significant elevation by comparing the normal participants with colorectal cancer cases for (8-OHdG) by P-value 0.054 and a significant elevation for Tumor necrosis factor alpha (TNF-α) by P-value 0.019 and interleukin-6 (IL6) by P-value <0.0001. While the data showed a significant depletion by P-value <0.0001 for SOD and POX. The findings of the current study reveal that 8-OHdG refers to the local oxidative stress in colorectal cancer and TNF-α is accountable for increasing the concentrations of IL6, which is linked with inflammation process in the surrounding of cancer cell.
The Effects of Power Mobility on Self-Care, Mobility, and Social Function in Very Young Children with Severe Multiple Developmental Impairments
Authors: Aceros Juan , Lundy Mary 
Published: July 2022

Abstract

Background:Children with impaired mobility often experience a negative impact on their overall development leading to depression, social isolation, “learned helplessness,” and a perceived lower quality of life. The present study explores the effects of Power Mobility Devices (PMD), in the form of modified ride-on toy cars, on independent mobility and social function in children under five-years of age with complex multiple developmental impairmentsMaterials and methods:In this study, 12 children with neuromuscular diagnosis, musculoskeletal, or genetic and metabolic progressive diseases were enrolled. Significant cognitive, visual, or communication impairment was not exclusionary. The age range of the participants was 12 to 54 months (M=32months). Two types of activation and steering modifications, 1) proportional control joystick and 2) line follower technologies were provided. Participants were evaluated pre/post using the Pediatric Evaluation of Disability Inventory (PEDI).Results:A paired t-test was conducted on each of the three subscales (self-care, mobility, and social/cognitive ) of the PEDI to assess changes occurred in individuals between the pre and post power mobility experiences. Data analysis clearly indicates a statistically significant difference in the positive direction in Functional Skill scores in all three domains (self-care, mobility and social function). Data analysis also indicates a statistically significant difference in two domains (self-care and social function) between pre and post experience with the post experience scores also being higher on the Caregiver Assistant Scale scores.Conclusion:Results from this study demonstrated group mean score improvements between pre and post power mobility experiences in Self-Care, Mobility, and Social/Cognitive function. The results of this quantitative study support the findings of two previous studies analyzing qualitative data. These results are strong indicators that early power mobility interventions could provide positive improvements in the quality of life of children with severe multiple developmental disabilities including visual impairments.
Eight-year trends in the effect of the Great East Japan Earthquake on obstetrics outcomes using the Fukushima Health Management Survey
Authors: Kyozuka Hyo , Ohira Tetsuya , Murata Tsuyoshi , Yasuda Shun , Ishii Kayoko , Fujimori Keiya , Goto Aya , Yasumura Seiji , Ota Misao , Hata Kenichi , Suzuki Kohta , Nakai Akihito , Ohto Hitoshi , Kamiya Kenji 
Published: July 2022

Abstract
Information on longitudinal effects of natural/environmental disasters on obstetrics outcomes is limited. This study analyzed longitudinal changes, over an 8-year period, in obstetrics outcomes after the Great East Japan Earthquake and the Fukushima power plant accident. We used data from the first 8 years of the Pregnancy and Birth Survey by the Fukushima prefectural government and compared data on obstetrics outcomes by year. Longitudinal changes in the occurrence of preterm birth before 37 gestational weeks, low birth weight, and anomalies in newborns were assessed in all six districts in Fukushima. The total number of participants was 57537. In 8 years, maternal age, rate of conception after sterility treatment, and incidence of cesarean section delivery tended to increase (p<0.001, p<0.001, and p=0.009, respectively). Although significant differences were observed in preterm birth and low birth weight among the districts (p=0.020 and p=0.025, respectively), no significant trend was observed in the preterm birth, low birth weight, and anomalies in newborns in all six districts (p=0.096, p=0.269, and p=0.239, respectively). The Great East Japan Earthquake and the Fukushima power plant accident were associated with increased incidence of cesarean section delivery but had no significant adverse effects on obstetrics outcomes.
Comparison of the safety and efficiency of temporary cardiac pacing methods during left bundle branch pacemaker implantation: Femoral vein pacing vs. atrial spiral pacing with electrodes placed at the ventricle
Authors: Li Zhenwei , Xu Qingqing , Huangfu Ning , Sun Zewei , Su Jia 
Published: July 2022

Abstract
Objective: To evaluate the safety and efficiency of replacing femoral vein pacing with atrial spiral pacing in the right ventricle for temporary cardiac pacing during left bundle branch pacemaker (LBBP) implantation. Method: A total of 179 patients who underwent temporary cardiac pacing (TCP) during LBBP were selected for retrospective analysis from April 2019 to April 2021 and divided into two groups: the atrial spiral electrode group (n=76) and the femoral vein electrode group (n=103). The following were observed: operation time; radiation dose; radiation time; operation expenses; hospitalization time; pacemaker parameters immediately after the operation and at 1 week, 1 month, 3 months, and 6 months after the operation; operation complications and femoral vein puncture point complications were observed in the two groups. Results: Compared to the femoral vein electrode group, the atrial electrode group had significantly lower operation times [(116.86±24.63) vs. (128.94±25.27) min, P < 0.05], radiation doses [(805.07±132.94) mgy vs. (846.42±87.37) mgy, P < 0.05], and decreased risk of a displaced or dislodged temporary pacing electrode during the operation [(0.00%) vs. (4.85%), P < 0.05]. The atrial electrode group did not have significant operation costs or material costs associated with femoral vein temporary pacing electrode implantation. In addition, the atrial electrode group did not have an increased risk of pacemaker-related infections, and the parameters of the pacemaker were unaffected. However, some puncture point complications appeared in the femoral vein electrode group (8 cases of local subcutaneous hematoma, 3 cases of pseudoaneurysms, 3 cases of arteriovenous fistula). Conclusion: The replacement of the femoral vein pacing electrode with an atrial spiral pacing electrode in the right ventricle for temporary cardiac pacing during left bundle branch pacemaker (LBBP) implantation was safe and effective.
Comparison of Isolated Calcaneal Spur Excision and Plantar Fasciotomy in Addition to Spur Excision In Patients with Plantar Heel Pain Accompanied by Calcaneal Spur
Authors: Saylık Murat , Fidan Fırat , Bal Emre , Lapçin Osman 
Published: July 2022

Abstract
Background: The aim of this study is to clinically compare isolated calcaneal spur excision and plantar fascia release in addition to spur excision in patients with plantar heel pain accompanied by calcaneal spur.Method: Patients who did not benefit from conservative treatment and underwent surgical excision of the calcaneal spur and/or plantar fasciotomy were retrospectively evaluated. The patients were divided into two groups according to the surgical procedure performed. Evaluation was done according to the pre- and postoperative foot function index (FFI) using pain and functional evaluation. Pain, disability, and activity restriction were evaluated with FFI. The radiological results and FFI scores of both groups were measured before and after surgery and the difference between the groups was compared.Results: Of the 46 patients in our study group, 30 (65.2%) were female and 16 (34.8%) were male. The average age was 41.2. There was a significant improvement in postoperative foot function index scores in both groups. There was no significant difference in postoperative functional results when the groups were compared.Conclusion: In patients whose plantar heel pain associated with calcaneal spur does not improve despite conservative treatments, both isolated spur excision and plantar fascia release in addition to spur excision may be effective treatment modalities that improve foot functions.
Timing of passage of first urine and meconium after birth in newborns delivered at a tertiary-care health center in Eastern India
Authors: Chowdhry Bhabesh Kant , Kumar Chandra Mohan , Gupta Prakriti , MF Giridhar , Choudhary Neha , Kumar Prdeep , Prasad Arun , Tiwari Lokesh 
Published: July 2022

Abstract
Introduction: Meconium is the first gastrointestinal discharge of a neonate. Most neonates usually pass first urine and meconium within 24 and 48 hours of birth respectively. Delayed passage of urine and stool is considered a pointer of gastrointestinal/ genitourinary structural or motility disorder and are a cause of worry for parents. There is a lack of studies in Indian babies. Also, previous studies have relied on mother’s recall of the event. Therefore, through this study, we embarked to identify the timing of passage of first urine and stool in newborns delivered at our center by reviewing their input/output charts. Methodology: This was a single-center, cross-sectional study conducted after obtaining IEC approval at a tertiary-care health center in Eastern India. The eligible newborns delivered in labour room/OT of AIIMS, were prospectively enrolled observed.Result: Approximately two third newborns passed first urine (69.7%) and meconium (62.7%) within 6 hours after delivery. The median time of passage of first urine was 4 [95% C.I. 1-7] hours of life. The median time of passage of meconium was 4 [1-8] hours of life, which was significantly higher for male [5 (6), (p= 0.036)] and preterm new born [6.3 (9), (p= 0.001)]. Conclusion: Median time of passage of first urine was 4 [1-7] hours of life; which was not influenced by the gender, gestation at birth and birth weight categories. Median time of passage of meconium was 4 [1-8] hours of life, which was significantly higher for male baby and preterm new born but no difference across the birth weight categories of the newborns.
Predictors of Stress among Nucleic Acid Sampling Support Nurses (NASSNs) during the Covid-19 Pandemic
Authors: Feng Ping , Gu Liyan , Lu Xiaoying , Hu Min , Weng Yanqiu , Chen Wenyao 
Published: July 2022

Abstract

Background
The COVID-19 pandemic has forced nucleic acid detection to be essential for prevention and control. The psychological and physical health of healthcare staff who conducted nucleic acid sampling should be paid attention to. This study aims to investigate the status and explore the predictors of stress among nucleic acid sampling support nurses (NASSNs) by an online survey.
Material and Methods
Totally 388 NASSNs were recruited for the research. An online cross-sectional survey with structured questionnaires was used, including socio-demographic information, the stressor scale of nucleic acid sampling nurses (SSNASN), and the challenge-hindrance stress scale (CHSS). T-tests, ANOVA, and multivariable linear regression model were used to analyze data.
Results
A total of 324 NASSNs filled out questionnaires online with a response rate of 83.51%. NASSNs had an overall mean score of (2.199 ± 0.917) for challenge stress and (2.014 ± 0.805) for hindrance stress. The item "the amount of responsibility I have" scored highest in the challenge stress dimension, while "the lack of job security I have" scored highest in the hindrance stress dimension. The predictors of challenge and hindrance stress include concern about the preparedness of NASSNs and their families, working environment, and competence of emergency disposal. An additional socio-demographic predictor of challenge stress was motivation, while that of hindrance stress was longer nursing experiences.
Conclusions
During the COVID-19 pandemic, stress among NASSNs was moderately low. The factors detected to be predictors of stress include motivation, nursing experiences, concern about the preparedness of NASSNs and their families, working environment, and competence in emergency disposal.
Ecological evolution analysis in collective intelligence design
Authors: Fu Zhong-Lin , Guo Wei , Wang Lei , Ma Jian , Zhang Jing 
Published: July 2022

Abstract
The transition from conventional design has been hastened by the development of network platforms, and innovative design dependent on social resources has emerged as a new design paradigm. The concept of collective intelligent design (CID) can be compared to a design ecosystem, in which members are constantly interacting with one another to advance the design process. The system will vary as the design evolves organically. How to assess the system's evolving state is the foundation of system optimization. To characterize the evolution of the CID system, this study proposed a matching network-based ecological network model and specified a comprehensive evaluation index for analyzing the evolutionary state. The model's validity is confirmed by an examination of Zhubajie (ZBJ), China's largest CID platform. The results demonstrate the ecological model developed in this study can capture the evolution essence of the ZBJ, and evaluation indicators demonstrate the ZBJ has been relatively mature. While the individuals' relationships are growing more distant, the engagement is becoming more effective. Additionally, the platform's sustainability has diminished while its resilience to external hazards has improved. Stakeholders may benefit from these ideas as they attempt to enhance the design process.
A Soft Sensing Method of Billet Surface Temperature Based on ILGSSA-LSSVM
Authors: LIU Jun , YANG Luying , CI Ying , FANG Jiangxiong , HOU Qingming , YANG Feng 
Published: July 2022

Abstract
It is difficult to measure the surface temperature of continuous casting billet, which results in the lack of important feedback parameters for further scientific control of billet quality. This paper proposes a sparrow search algorithm(SSA) to optimize the least square support vector machine(LSSVM) model for surface temperature prediction of billet, which is improved by Logistic chaotic mapping and Golden sine algorithm (Improve Logistic Golden Sine Sparrow Search Algorithm LSSVM, ILGSSA-LSSVM). Based on LSSVM, the optimal solution of sparrow population is improved by improved Logistic chaos mapping and Golden sine algorithm as the value of penalty factor \(\gamma\)and kernel parameter\(\sigma\). Global optimization method is adopted to find the optimal parameter combination, which reduces the influence of blindly determining parameters on the prediction accuracy. The results show that the maximum error of ILGSA-LSSVM soft Sensing model is 3.85733℃, the minimum error is 0.0174℃, and the average error is 0.05805℃. The performance of ILGSA-LSSVM soft Sensing model is better than that of traditional least square support vector machine, BP neural network and gray Wolf optimized least square support vector machine.
A nomogram for predicting postoperative overall survival of patients with lung squamous cell carcinoma: a SEER-based study
Authors: Rao Jin , Yu Yue , Zhang Li , Wang Pei , Wang Xuefu , Wang Zhinong 
Published: July 2022

Abstract

Background
Lung squamous cell carcinoma (LSCC) is a common subtype of non-small cell lung cancer. Our study aimed to construct and validate a nomogram for predicting overall survival (OS) for postoperative LSCC patients.
Methods
A total of 8,078 patients eligible for recruitment between 2010 and 2015 were selected from the Surveillance, Epidemiology and End Results database. The study outcomes were 1-, 2-, and 3-year OS. Analyses performed included univariable and multivariable Cox regression, receiver the operating characteristic (ROC) curves, calibration plots, decision curve analysis (DCA), and Kaplan-Meier survival curves.
Results
Seven variables were selected to establish the nomogram for LSCC. The area under the curve in ROC curve revealed 0.658, 0.651, and 0.647 in the training cohort and 0.673, 0.667, and 0.658 in the validation cohort at 1-, 2-, and 3-year survival. The calibration curves showed satisfactory consistencies between nomogram-predicted and observed survival probability. DCA showed great clinical net benefit. In risk stratification systems, patients were divided into three risk groups with a significant difference in OS in Kaplan-Meier curves (P༜0.001).
Conclusions
A prognostic nomogram for OS of postoperative LSCC patients was developed and validated, which may assist clinicians in evaluating prognosis and providing highly individualized therapy.
Effects of midwife-directed breastfeeding training programmes on breastfeeding outcomes: A systematic review and meta-analysis
Authors: Wang Tianci , Shang Meimei , Chow Ka Ming 
Published: July 2022

Abstract
BackgroundAppropriate breastfeeding training for midwives is necessary to enhance their knowledge, attitude, and practice (KAP). However, evidence surrounding the effects of midwife breastfeeding training programmes is insufficient to draw a conclusion.ObjectiveThis systematic review aims to identify, summarise, and critically analyse the available literature to evaluate the effects of midwife breastfeeding training programmes on the midwives’ KAP towards breastfeeding and breastfeeding initiation, duration and rates among postnatal mothers.MethodsNine English and six Chinese databases were searched with relevant key words. The methodological quality of the included studies was assessed by two reviewers independently using the Joanna Briggs Institute critical appraisal checklists.ResultsNine English and one Chinese articles were included in this review. Five articles investigating midwives’ KAP towards breastfeeding reported positive results (p < 0.05). The meta-analysis revealed that breastfeeding training programmes significantly improved midwives’ breastfeeding-related knowledge and skills (standardised mean difference = 1.33; 95% confidence interval, 0.98 to 1.68; p < 0.01; I2 = 36%), as well as their attitude towards breastfeeding (p < 0.05). An additional five articles measured the effects of breastfeeding training programmes on the initiation, duration, and rates of breastfeeding among postnatal mothers. Following the implementation of a breastfeeding training programme for midwives, mothers had significantly longer durations of exclusive breastfeeding (p < 0.05), fewer breastfeeding challenges (p < 0.05) (e.g. breast milk insufficiency), and higher satisfaction with breastfeeding counselling (p < 0.01), and fewer infants received breast milk substitutes in their first week of life without medical reasons (p < 0.05) in the intervention group compared with the control group. However, no significant effects were seen on the initiation and rates of breastfeeding after implementation of the programmes.ConclusionsThis systematic review has demonstrated that midwife breastfeeding training programmes could improve midwives’ KAP towards breastfeeding. Breastfeeding training programmes also had a statistically significant effect on exclusive breastfeeding rate among postnatal mothers. We suggest that future breastfeeding training programme should incorporate counselling skills alongside breastfeeding knowledge and skills training.RegistrationThis systematic review has been registered in the International prospective register of systematic reviews (PROSPERO) (ID: CRD42022260216).
Uterine sarcomas resembling dermatofibrosarcoma protuberans showing COL1A1-PDGFB fusion: a case report and review of the literature
Authors: Wang Zheng , Zhou Jie , Liu Shuang , Ding Yongling 
Published: July 2022

Abstract
Background: Collagen type 1α1–platelet-derived growth factor β-chain (COL1A1-PDGFB) fusion uterine fibrosarcoma is a rare, recently discovered uterine sarcoma characterised by unique gene rearrangements, of which only four cases have been reported. This subtype is found in the body of the uterus or cervix, with histological features resembling dermatofibrosarcoma protuberans (DFSP), diffuse CD34 expression in tumour cells and COL1A1-PDGFB fusion.Case presentation: A 38-year-old female patient complaining of amenorrhea for 3 months presented with a cloudy hypoechoic fluid measuring 98 × 91 mm in the right adnexa on B-scan ultrasonography, for which laparoscopic lumpectomy was performed accordingly. Histological sections demonstrated high cellularity with mild to moderate atypia, morphological uniformity, a scant cytoplasm, oval to spindle-like nuclei, inconspicuous nucleoli and evident mitotic figures. Salient storiform and herringbone patterns of growth were observed. On immunohistochemical analysis, the tumour cells exhibited diffuse and strong positive expression of CD34; negativity for AE1/AE3, SMA, desmin, STAT6, S100 and SOX-10 and focal positivity for CD99, Bcl-2, CD10 and CylinD1. COL1A1-PDGFB fusion was identified by fluorescence in situ hybridisation. The patient remained disease-free within the 17-month follow-up with no additional treatment after the lumpectomy.Conclusions: This is the fifth case of COL1A1-PDGFB fusion uterine fibrosarcoma reported in the literature. Previous studies have found that this subtype overlaps with DFSP in histopathological, immunohistochemical and molecular characteristics. Of these five cases, two resulted in mortality, implying a risk of poor prognosis.
Microphysiological vascularized solid tumor model for drugs and cell therapies screening
Authors: Reales-Calderon Jose Antonio , Lam Maxine S Y , Ow Jin Rong , Aw Joey , Tan Damien , Adriani Giulia , Pavesi Andrea 
Published: July 2022

Abstract
Solid tumors present particular obstacles for cell therapies, which need to be reflected in pre-clinical models for effective therapy validation. For example, tumor biology varies along with the tumor mass, and the tumor microenvironment (TME), consisting of vasculature, stromal cells and immune cells, can become corrupted and promote resistance or prevent cell therapy targeting and efficacy. We developed an in vitro vascularized human solid tumor model which recapitulates these key features of the TME in a microfluidic device, allowing for more reliable and convenient drug and cell therapy validation. The model consists of a solid tumor spheroid surrounded by a perfusable vasculature, with a permeability value similar to in vivo physiology. We used the model to identify tumor-vasculature interactions, evaluate drug response, and evaluate cell therapy infiltration and cytotoxicity. By removing the cultured tumor microtissue from the device and performing spatial transcriptomics on standard paraffin-embedded sections, we identified known and novel genes involved in creating a pro-tumorigenic microenvironment.