bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘It was like being hit with a brick’: a qualitative study on the effect of clinicians’ delivery of a diagnosis of eye disease for patients in primary and secondary care
Authors: Ferrey Anne , Moore Lucy , Jolly Jasleen Kaur 
Published: July 2022

ObjectivesTo explore patients’ experiences of getting a diagnosis of eye disease, the psychological impact of this and how this could be improved.DesignAn exploratory qualitative interview study using a narrative approach and inductive methods.SettingThis study was conducted with patients who had attended ophthalmic appointments in primary and secondary care and in opticians located in the South of England.Participants18 people diagnosed with eye disease in England.ResultsFour themes were identified: the convoluted process of being diagnosed, the impact of clinicians’ words, the search for information and reflections on what could be improved. The prolonged wait for a definitive diagnosis was a source of frustration and anxiety for many patients. Professionals’ words and tone when delivering a diagnosis sometimes affected a patient’s view of their diagnosis and their later ability to come to terms with it. Patients were desperate for information, but many felt they were not provided with sufficient information at the time of diagnosis and did not know whether to trust information found online. Participants felt the provision of a hospital liaison service and/or counselling could mitigate the impact on patients and families.ConclusionsInteractions with clinicians can have a lasting impact on how a diagnosis is experienced and how well the patient is able to come to terms with their visual impairment. Receiving little or no information left patients feeling lost and unsupported. This led them to search for information from less reliable sources. Clinicians should consider how they communicate a diagnosis to patients, how and when they offer information about diagnosis and prognosis and where possible signpost patients to additional support systems and counselling services as early as possible.
Analgesic efficacy of erector spinae plane blocks for lumbar spine surgery: a randomized double-blind controlled clinical trial
Authors: Avis Geoffrey , Gricourt Yann , Vialatte Pierre Baptiste , Meunier Victor , Perin Mikael , Simon Natacha , Claret Pierre-Geraud , El Fertit Hassan , Lefrant Jean-Yves , Bertrand Martin , Cuvillon Philippe 
Published: July 2022

IntroductionErector spinae plane block has been proposed to reduce opioid use and improve pain relief with controversial results. This randomized clinical study aimed to assess the efficacy of erector spinae plane block in major spine surgery including multimodal and ‘Enhance Recovery After Surgery’ programs.MethodAfter institutional review board approval, adult patients undergoing elective lumbar spine surgery with standardized general anesthesia, rehabilitation and multimodal analgesia protocols were randomly allocated to receive bilateral ultrasound-guided block with saline versus ropivacaine (3.75 mg/mL). Before surgery, a bilateral erector spinae plane block was performed at lumbar level (third vertebrae) with 20 mL of solution for each side. The primary outcome was morphine consumption after 24 hours. Secondary outcomes included pain scores and side effects, from postanesthesia care unit to discharge, and questionnaires at 3 months on pain and quality of life (EQ-5D).ResultsFrom November 2019 to July 2021, 50 patients were enrolled with similar characteristics and surgery for each group. After the first 24 hours, there was no statistical difference regarding cumulative intravenous morphine consumption between ropivacaine and saline groups: 7.3 mg (3.7–19) vs 12.5 mg (3.5–26) (p=0.51). Over the five postoperative days, opioid sparing, pain scores and side effects were similar between groups. At 3 months, pain relief, incidence of chronic pain and EQ-5D were similar between groups.DiscussionErector spinae plane block used in conjunction with ‘Enhance Recovery After Surgery’ and multimodal analgesia protocols provides limited reduction in opioid consumption and no long-term benefits.Trial registration numberEudraCT 2019-001678-26.
Dielectric spectroscopy of solid solutions based on sodium–potassium–cadmium in the temperature range (10 ÷ 900) K
Authors: Moysa M. O. , Andryushin K. P. , Pavlenko A. V. , Kubrin S. P. , Reznichenko L. A. 
Published: July 2022

This paper studies the dielectric spectra of solid solutions (SS) of the system (1 − x − y)NaNbO3–[Formula: see text]KNbO3 –[Formula: see text]CdNb2O6 [Formula: see text]= 0.075, [Formula: see text]= 0.05 ÷ 0.30 in the temperature range (10 ÷ 900) K. The formation of a local maximum was established in the interval (260 ÷ 300) K at small [Formula: see text] values, which, as KNbO3 increases, is gradually blurred and becomes an inflection point. Detected in SS with [Formula: see text] = 0.05 ÷ 0.10, the shift of the maxima of dependences [Formula: see text]′/ [Formula: see text]0([Formula: see text]) and [Formula: see text]′′/[Formula: see text]0 ([Formula: see text]), depending on the frequency of the electric field at the temperature ranges (300 ÷ 304) K and (258 ÷ 271) K, is not related to relaxation. This anomaly may indicate a crystallographic disorder to A and B positions. The conclusion is made about the expediency of using the obtained results for the development of functional ferroactive materials.
New evidence of Neolithic industries from the West Garo Hills, northeastern India
Authors: Padhan Tosabanta 
Published: July 2022

Abstract
This paper is based on the field investigations conducted in the West Garo Hills of northeastern India. The work presents a brief report on the Neolithic manufacturing sites of the West Garo Hills. It addresses the various issues of lithic sequence, typological classifications, lithic technology, settlement pattern and site distribution pattern of the known sites and newly discovered sites in the West Garo Hills. Large clusters of Neolithic manufacturing sites have been located on the hilltops and hillslopes close to present-day rivers, streams, natural springs, water channels and modern Garo community habitats. Dolerite raw materials were mostly preferred for fashioning the artefacts, and manufacturing units are found close to the dyke basalt rock sources. Findings of habitation deposits or pottery are very sparse; however, evidence of plant and animal domestication, burial, bone tools, and metal use pose new hypotheses on their use owing to poor preservation. The Palaeolithic evidence and the region's transition to early farming cultures remain vague.
hXDP
Authors: Brunella Marco Spaziani , Belocchi Giacomo , Bonola Marco , Pontarelli Salvatore , Siracusano Giuseppe , Bianchi Giuseppe , Cammarano Aniello , Palumbo Alessandro , Petrucci Luca , Bifulco Roberto 
Published: July 2022

The network interface cards (NICs) of modern computers are changing to adapt to faster data rates and to help with the scaling issues of general-purpose CPU technologies. Among the ongoing innovations, the inclusion of programmable accelerators on the NIC's data path is particularly interesting, since it provides the opportunity to offload some of the CPU's network packet processing tasks to the accelerator. Given the strict latency constraints of packet processing tasks, accelerators are often implemented leveraging platforms such as Field-Programmable Gate Arrays (FPGAs). FPGAs can be re-programmed after deployment, to adapt to changing application requirements, and can achieve both high throughput and low latency when implementing packet processing tasks. However, they have limited resources that may need to be shared among diverse applications, and programming them is difficult and requires hardware design expertise.
We present hXDP, a solution to run on FPGAs software packet processing tasks described with the eBPF technology and targeting the Linux's eXpress Data Path. hXDP uses only a fraction of the available FPGA resources, while matching the performance of high-end CPUs. The iterative execution model of eBPF is not a good fit for FPGA accelerators. Nonetheless, we show that many of the instructions of an eBPF program can be compressed, parallelized, or completely removed, when targeting a purpose-built FPGA design, thereby significantly improving performance.
We implement hXDP on an FPGA NIC and evaluate it running real-world unmodified eBPF programs. Our implementation runs at 156.25MHz and uses about 15% of the FPGA resources. Despite these modest requirements, it can run dynamically loaded programs, achieves the packet processing throughput of a high-end CPU core, and provides a 10X lower packet forwarding latency.
Compositional Verification of Railway Interlocking Systems
Authors: Haxthausen Anne Elisabeth , Fantechi Alessandro 
Published: July 2022

Model checking techniques have often been applied to the verification of railway interlocking systems, responsible for guiding trains safely through a given railway network. However, these techniques fail to scale to the interlocking systems controlling large stations, composed of hundreds and even thousands of controlled entities, due to the state space explosion problem. Indeed, interlocking systems exhibit a certain degree of locality that allows some reasoning only on the mere set of entities that regard the train movements, but safe routing through a complex station layout requires a global reservation policy, which can require global state conditions to be taken into account.
In this article, we present a compositional approach aimed at chopping the verification of a large interlocking system into that of smaller fragments, exploiting in each fragment a proper abstraction of the global information on routing state. A proof is given of the thesis that verifying the safety of the smaller fragments is sufficient to verify the safety of the whole network. Experiments using this compositional approach have shown important gains in performance of the verification, as well as in the size of affordable station layouts.
Development Characteristics and Sensitivity Analysis of Expansive Soil Slope
Authors: Jiang Pengfei , Kong Yuanyuan , Song Zhenyu , Zhao Ruixin , Zhan Jiewei , Lin Xuhui 
Published: July 2022

According to laboratory tests of soil samples of Wangyan highway landslide, the mechanism of formation of landslide and the degree of sensitivity of various factors to slope stability are analyzed. It is found that the landslide is destroyed by the properties of expansive soil, the existence of water in the cracks, the loading of artificial filling, and the traction of old landslide. The soil samples were tested for SEM and MIP tests by lyophilization, and the particle morphology, the mode of combination, porosity, and connectivity of the sliding zone soil were observed by a scanning electron microscope. Results show that the sliding zone developed many microfissures and the clay minerals arranged tightly, the pore of

size
<
0.1

μm was 60% in undisturbed soil, and the pores of different sizes were distributed uniform in reconstituted soil. The undisturbed soil had typical nonlinear rheological property; The deformation rate of reconstituted was bigger; When the load was 50 kPa and 200 kPa, an expansion phenomena occurred in the sliding zone, which indicated that microstructure could influence the deformation. The strength attenuation of expansive soil slope due to the high content of montmorillonite in the sliding body and the high water content in the cracks are two major factors of the Wangyan highway landslide. Based on the results of previous studies, the

a

,

n

, and

m

values of fitting parameters of Fredlund-Xing soil-water characteristic curve are predicted by using the basic physical properties of soil. It is found that the air intake value and residual suction value of filled soil (loose and broken) and completely weathered sandstone are small, and the water holding capacity in the middle suction range is relatively good. Then, the finite difference software Flac3D was used to build a three-dimensional geological model. The influence of water content, highway load, filling weight, and slope angle on slope stability is considered comprehensively. The order of sensitivity of slope stability about various factors is as follows:

water

content
>
slope

angle
>
highway

load
>
filling

weight

. The results of research can provide a scientific basis for the treatment, protection, and reinforcement of the Wangyan highway landslide.
Preclinical Development of [211At]meta- astatobenzylguanidine ([211At]MABG) as an Alpha Particle Radiopharmaceutical Therapy for Neuroblastoma
Authors: Batra Vandana , Samanta Minu , Makvandi Mehran , Groff David , Martorano Paul , Elias Jimmy , Ranieri Pietro , Tsang Matthew , Hou Catherine , Li Yimei , Pawel Bruce , Martinez Daniel , Vaidyanathan Ganesan , Carlin Sean , Pryma Daniel A. , Maris John M. 
Published: July 2022

Abstract

Purpose:
[131I]meta-iodobenzylguanidine ([131I]MIBG) is a targeted radiotherapeutic administered systemically to deliver beta particle radiation in neuroblastoma. However, relapses in the bone marrow are common. [211At]meta-astatobenzylguanidine ([211At] MABG) is an alpha particle emitter with higher biological effectiveness and short path length which effectively sterilizes microscopic residual disease. Here we investigated the safety and antitumor activity [211At]MABG in preclinical models of neuroblastoma.

Experimental Design:
We defined the maximum tolerated dose (MTD), biodistribution, and toxicity of [211At]MABG in immunodeficient mice in comparison with [131I]MIBG. We compared the antitumor efficacy of [211At]MABG with [131I]MIBG in three murine xenograft models. Finally, we explored the efficacy of [211At]MABG after tail vein xenografting designed to model disseminated neuroblastoma.

Results:
The MTD of [211At]MABG was 66.7 MBq/kg (1.8 mCi/kg) in CB17SC scid−/− mice and 51.8 MBq/kg (1.4 mCi/kg) in NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice. Biodistribution of [211At]MABG was similar to [131I]MIBG. Long-term toxicity studies on mice administered with doses up to 41.5 MBq/kg (1.12 mCi/kg) showed the radiotherapeutic to be well tolerated. Both 66.7 MBq/kg (1.8 mCi/kg) single dose and fractionated dosing 16.6 MBq/kg/fraction (0.45 mCi/kg) × 4 over 11 days induced marked tumor regression in two of the three models studied. Survival was significantly prolonged for mice treated with 12.9 MBq/kg/fraction (0.35 mCi/kg) × 4 doses over 11 days [211At]MABG in the disseminated disease (IMR-05NET/GFP/LUC) model (P = 0.003) suggesting eradication of microscopic disease.

Conclusions:
[211At]MABG has significant survival advantage in disseminated models of neuroblastoma. An alpha particle emitting radiopharmaceutical may be effective against microscopic disseminated disease, warranting clinical development.
Reading the Juggler of Notre Dame
Authors: Ziolkowski Jan M. 
Published: July 2022

In this two-part anthology, Jan M. Ziolkowski builds on themes uncovered in his earlier The Juggler of Notre Dame and the Medievalizing of Modernity. Here he focuses particularly on the performing arts.
Part one contextualises Our Lady’s Tumbler, a French poem of the late 1230s, by comparing it with episodes in the Bible and miracles in a wide variety of medieval European sources. It relates this material to analogues and folklore across the ages from, among others, Persian, Jewish and Hungarian cultures. Part two scrutinizes the reception and impact of the poem with reference to modern European and American literature, including works by the Nobel prize-winner Anatole France, professor-poet Katharine Lee Bates, philosopher-historian Henry Adams and poet W.H. Auden.
This innovative collection of sources introduces readers to many previously untranslated texts, and invites them to explore the journey of Our Lady’s Tumbler across both sides of the Atlantic.
Reading the Juggler of Notre Dame: Medieval Miracles and Modern Remakings will benefit scholars and students alike. The short introductions and numerous annotations shed light on unusual beliefs and practices of the past, making the readings accessible to anyone with an interest in the arts and an openness to the Middle Ages.
A Variational Interpolation Method for Gridding Weather Radar Data
Authors: Brook Jordan P. , Protat Alain , Soderholm Joshua S. , Warren Robert A. , McGowan Hamish 
Published: July 2022

Abstract
Observations made by weather radars play a central role in many aspects of meteorological research and forecasting. These applications commonly require that radar data be supplied on a Cartesian grid, necessitating a coordinate transformation and interpolation from the radar’s native spherical geometry using a process known as gridding. In this study, we introduce a variational gridding method and, through a series of theoretical and real data experiments, show that it outperforms existing methods in terms of data resolution, noise filtering, spatial continuity, and more. Known problems with existing gridding methods (Cressman weighted average and nearest neighbor/linear interpolation) are also underscored, suggesting the potential for substantial improvements in many applications involving gridded radar data, including operational forecasting, hydrological retrievals, and three-dimensional wind retrievals.
Negative Lymph Node Is an Independent Prognostic Factor for Stage III Gastric Cancer Patients After Curative Gastrectomy: A Surveillance, Epidemiology, and End Results-Based Study
Authors: Liu Linmei , Ren Jigang , Wang Guan , Cui Yingjuan , Li Fang , Wang Daxue , Lei Xiao 
Published: July 2022

Background Negative lymph node (NLN)’ s prognostic impact on stage III gastric cancer (GC) patients after curative gastrectomy has not been rigorously studied. We aimed to explore the relationship between NLNs count and outcomes of stage III GC patients. Methods We retrospectively investigated stage III gastric cancer cases between 2008 and 2018 from Surveillance, Epidemiology, and End Results (SEER) database. Variables were compared by chi2 test. Kaplan-Meier methods and COX proportional hazard models were used to ascertain independent prognostic factors. Survival differences among the subgroups were analyzed to assess the effects of NLN count on overall survival (OS) in stage III GC patients. Results 2373 patients with curative gastrectomy for stage III GC were identified. Univariate analysis demonstrated that NLNs count >14 was associated better 5-year OS (43.7% VS 23.1%, P< .001) comparing with the NLNs count ≤ 14. Subgroup analysis showed that the NLNs count could predict survival in both node-negative and node-positive patients. Multivariate analysis revealed NLNs count is an independent prognostic factor. Conclusions The NLNs count is an independent prognostic factor for survival in stage III gastric cancer patients after curative gastrectomy and should be recommended for clinical applications.
Mastoid Growth and the Configuration of Cochlear Implant Electrode Lead
Authors: Alhabib Salman F. , Almuhawas Fida , Hagr Abdulrahman , Alzhrani Farid , Hamed Nezar , Alenzi Saad , Abdelsamad Yassin , Dhanasingh Anandhan 
Published: July 2022

Objectives To study the changes in the coiled configuration of electrode excess lead in the mastoid cavity in the cochlear implant recipients over time. Methods Post-operative CT scans at two different appointments of fourteen patients with cochlear implants (CI) were retrospectively analyzed using a DICOM viewer software (3D-slicer). Mastoid thickness (MT) was measured in the oblique coronal plane from the round window (RW) entrance to the mastoid edge and inter-cochlear distance (ICD) was measured in the axial plane at the fundus level between two ears. 3D segmentation of the entire inner ear of both sides and coiled electrode excess lead was performed to visually compare the changes in coiled configuration between the two CT scan time points. Result MT and ICD increased logarithmically with the patient’s age, as has been measured from both the 1st and the 2nd CT scans and a weak linear correlation between MT and ICD was observed. Growth in MT and ICT measured between the time of 1st and 2nd CT scans showed a strong linear correlation. In eight cases, changes in the electrode excess lead have been observed in the 2nd CT scan, either a change in the coiling configuration of electrode excess lead or shifted laterally toward the mastoid edge. The ICD growth between the 1st and the 2nd CT scans was >2 mm in only seven cases and all of them were children. All other six cases had no observed changes in the coiled electrode lead. In addition, the mastoid growth between the 1st and the 2nd CT scan was >2.5 mm in only 4 cases. Conclusion Coiled configuration of electrode excess lead could change when the MT and ICD increased over time.
Pain management after tonsillectomy—by demand or by-the-clock—is there a difference?
Authors: Gostian Magdalena , Stilkerich Lisa , Pauly Anne , Waldfahrer Frank , Balk Matthias , Rupp Robin , Allner Moritz , Iro Heinrich , Gostian Antoniu-Oreste 
Published: July 2022

Purpose To improve pain management after tonsillectomy (TE) by comparing individual analgesic management by demand versus a fixed-scheduled analgesic treatment protocol in a prospective trial. Patients and Methods Forty consecutive patients received individual pain treatment by demand (control group) followed by 40 patients who were treated by a fixed-scheduled four-staged escalating analgesic protocol (intervention group) after TE. Minimum and maximum pain as well as pain on ambulation (NRS 0-10) on the first postoperative day were defined as primary objectives. Secondary endpoints comprised the analgesic score, treatment-related side effects/pain-associated impairments, wish for more pain medication, and patient satisfaction. Patients were surveyed using the standardized and validated “Quality Improvement in Postoperative Pain Treatment” (QUIPS) questionnaire. Results Patients of the control group reported comparable minimum (2.03 ± 1.42 vs 2.38 ± 1.79, P = 0.337, r = 0.110) and maximum pain (6.65 ± 2.10 vs 6.93 ± 1.86, P = 0.536, r = 0.07) and pain on ambulation (4.73 ± 2.26 vs 5.18 ± 2.19, P = 0.370, r = 0.10) compared to the intervention group. Patients in both groups were comparably well satisfied with the pain treatment (7.53 ± 2.40 vs 7.73 ± 2.30, P = 0.704, r = 0.04), experienced similar side effects and functional impairments ( P > 0.050, Φ < 0.3), and did not ask for much more analgesic medication ( P = 0.152, Φ = 0.160). Conclusion Pain control following TE was not distinctly affected by applying a fixed-scheduled analgesic treatment protocol compared to individual analgesic therapy. In conclusion, analgesic treatment after TE remains unsatisfying. Consequently, further efforts are needed to achieve a standardized and effective approach to the underlying pathophysiological causes of pain following TE.