bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Evaluation of Different Phases of Covid-19 Pandemic using by Hybrid Approach Modeling
Authors: Ergin Mahmut Esad 
Published: October 2022

Abstract

The COVID-19 pandemic has presented major difficulties to public health organizations and governments all over the world. Administrations have taken various measures to prevent the spread of COVID-19 virus, which emerged instantly, about which they did not know much, and which was defined as a pandemic by WHO on March 11, 2020 (WHO, 2022). Within the scope of this study, it is aimed to establish a hybrid model of the impacts of the pandemic on passenger behavior and transportation mode preferences and to evaluate passenger behavior accordingly. Hybrid model consists of cluster analysis and discrete choice models in order. First of all, a comprehensive survey was conducted via online platform to determine the travel behaviors of individuals in three phases of the pandemic which are before (pre-COVID19), during (during COVID19), and after the pandemic (post-COVID19). As a result of the models, it can be said that the factors affecting the mode preference of individuals do not differ between COVID sensitive or COVID unrelated clusters. However, when the effect on mode selection is examined, it seems that these factors have a greater effect on mode preference choices for the COVID sensitive cluster. With the effect of the pandemic, people's perceptions about public transportation modes have been negatively affected.
The effect of chlorantraniliprole on the transcriptomic profile of Spodoptera frugiperda: a typical case analysis for the response of a newly invaded pest to an old insecticide
Authors: He Hualiang , Li Yi , Shu Haijuan , Lin Yufeng , Zhang Zhengbing , Qiu Lin , Ding Wenbing , Gao Qiao , Xue Jin , Li Youzhi 
Published: October 2022

Abstract
Background
Chlorantraniliprole is a diamide insecticide widely used in China over the last 15 years. The fall armyworm (FAW), Spodoptera frugiperda, newly invaded China in 2019. The response of FAW to chlorantraniliprole deserves more attention, in the context of many destructive lepidopteran species are resistant to diamide insecticides and the patent on core chemical of chlorantraniliprole in China expired in August 2022.
Methods and results
This study investigated the response profile in larvae under chlorantraniliprole-induced (LC50) stress using methods of bioassay, RNA-Seq and qPCR. We observed growth inhibition and lethal effects in FAW larvae, but at a relatively high LC50 value compared to other several pests. Additionally, under chlorantraniliprole-induced stress, 3309 unigenes were found to be differentially expressed genes (DGEs). The impacted genes included 137 encoding for detoxification enzymes, 29 encoding for cuticle proteins, and 20 key enzymes involved in the chitin metabolism, which all associated with metabolic resistance. Finally, we obtained the single nucleotide polymorphisms (SNPs) of two RyR genes, which are the target proteins for chlorantraniliprole. We also investigated the causes of the high LC50 value in our FAW, which possibly related to the stabilized 4743M on SNP frequency of RyR. These findings documented the genetic background of RyR of FAW and indicated that application of chlorantraniliprole has a high risk of controlling FAW in China.
Conclusion
In brief, our results provide a better understanding of the mechanisms of chlorantraniliprole toxicity and detoxification in FAW, and will aid in monitoring the development of resistant strains for a newly pest to an old insecticide.
Age and Gender Related Paraoxonase I Gene Polymorphisms rs662 and rs854560 in Subjects with Metabolic Syndrome in Fars ethnic group
Authors: Marjani Abdoljalal , Poursharifi Nahid , Sajedi Atefe , Tatari Mahin 
Published: October 2022

Abstract
Background: The aim of the study was to determine the Paraoxonase I Gene Polymorphisms in subjects with and without metabolic syndrome (MetS) in the Fars ethnic group.
Methods: Polymorphisms determinationof the paraoxonase1 gene was done by Polymerase Chain Reaction and Restriction Fragment Length Polymorphism analysis in subjects with and without MetS.
Results: The MM, LM, and LL genotypes frequencies of the PON1- L55M polymorphism were 2.5, 37.5 and 60%; and 27.5, 34.5 and 38% and; 19.4, 50 and 30.6% and 17.2, 58.6 and 34.2% in females and males with and without MetS, respectively. The QQ, QR, and RR genotypes frequencies of the PON1 - Q192R polymorphism were 50, 47.6 and 2.4%; and 56.8, 34.1 and 9.1% and; 61, 29.2 and 9.8% and 56.3, 35.4 and 8.3% in females and males with and without MetS, respectively.
Conclusions: Our study suggested that the decrease of PON1 enzymatic activity in both genders is an important finding, but the L55M genotype in females with MetS is more important than PON1 Q192R polymorphism. This genotyping difference for L55M in females may be important to make the females more vulnerable than males to MetS.
Pure flexural guided wave excitation in hollow cylinders by applying helical surface tractions
Authors: Hao Dong , Wenjun Wu , Wentao Wu 
Published: October 2022

Abstract
Pure flexural mode excitation of helical waves in hollow cylinders by applying helical surface tractions, equivalent to exciting obliquely propagating plate waves in the unwrapped plate, is reported. However, this approach cannot be generalized with theoretical underpinnings. The response of hollow cylinders under helical surface tractions is investigated using normal mode expansion method. Purity of the target flexural mode depends on the mode wave structures at excitation frequencies and the helix angle of the helical excitation. With helical surface tractions, only flexural modes with large circumferential and longitudinal displacements, usually torsional flexural modes, can be effectively generated. The target flexural mode and excitation frequency should be selected carefully for better purity. The helix angle for the target mode should diverge considerably from other modes, especially those with large circumferential and longitudinal displacements. The apparently oblique propagation of the flexural mode can also be explained theoretically. The helically excited flexural mode comprises two orthogonal wave structures with identical flexural modes that are out of phase in the propagation direction, causing periodically changing circumferential orientation of the combined wave structure and oblique wave front. Finite element simulations and experiments agree well with theoretical predictions.
Residual Neural Network-Based Observer Design for Continuous Stirred Tank Reactor Systems
Authors: Liu Shi , Chen Song , Chen Tehuan , Ren Zhigang 
Published: October 2022

Abstract

Continuous stirred-tank reactor (CSTR) is a common reactor in the chemical industry. The accurate monitoring of the concentration of the product and the internal temperature of the reaction vessel is a prerequisite for obtaining the desired product. This paper proposes a novel observer based on the residual neural networks for CSTR systems. Firstly, the mathematical model of the CSTR reaction is given, as well as detailed description of the structure and equations of the residual neural networks and the designed observer. Then the matrix method is used for nonlinear isolation of the residual neural networks and the theory of quadratic constraints for nonlinear activation functions of the neural networks is applied. Thus, the convergence of the proposed observer is analyzed theoretically in detail. Finally, the numerical simulations are implemented to demonstrate that the proposed residual neural network-based observer can quickly and accurately monitor the state changes during the CSTR reaction.
Determinants of Soil and Water Conservation Measures for Sustainable Land Management Practices in the Ethiopian Highlands: The Case of Hadi Micro-watershed
Authors: Assefa Alem-meta , Kefyalew Aberaw 
Published: October 2022

Abstract
This study presents an assessment of smallholder farmers’ perception towards adopting soil and water conservation practices in Hadi micro-watershed. The data were collected from 203 sample households using questionnaire, focus group discussions, and interview. The data were analyzed using descriptive and inferential statistics. The result of the study revealed that about 60.6% of sample households were adopters and 39.4% were non-adopters of soil and water conservation measures. The study was also focused on soil loss estimation and prioritization based on Revised Universal Soil Loss Equation model using the application of Geographic Information System software. The result of the analysis showed that the mean soil erosion rate of the watershed is 28.063 t/ha/year in the year 2018/2019. Moreover, the total soil loss in the study area is 109,642.25 tons. The results of the binary logistics regression model also revealed that sex of respondents, farm size, access to training, extension service, and access to credit service were positively correlated with the adoption of soil and water conservation measures. On the other hand, age, educational status, family size of household heads, and farm distance were found to be negatively correlated. The result of the study suggests they majority of the farmers are aware and perceived soil erosion by water and land degradation as a problem in their farm plots. Furthermore, they also able to identify the different causes of soil erosion in their land based on their farming experience.
Selenium prevents follicular granulosa cells from apoptosis induced by mercury through inhibition of ATF6/CHOP pathway in laying hens
Authors: Cheng Binyao , Shi Yizhen , Wu Qiujue , Wang Yuqin , Ma Yan 
Published: October 2022

Abstract
The purpose of this research was to explore the effect of selenium on mercury-mediated apoptosis of follicular granulosa cells in laying hens. Moreover, the ATF6/CHOP pathway was investigated to explore the mechanism in this progress. Hg, Se, and 4-phenyl butyric acid were used alone or in combination to treat the cells. Our results showed that the nuclear in cells became condensate after Hg exposure, while Se addition significantly alleviated this change. Hg exposure significantly induced the apoptosis and the reduction of mitochondrial membrane potential in cells (P < 0.05), Nevertheless co-treatment of Se significantly inhibited these effects (P < 0.05). Additionally, Hg exposure dramatically elevated the gene expressions of Bax/Bcl-2 (P < 0.05), Caspase-3 (P < 0.05), Caspase-9 (P < 0.05), protein kinase RNA-like endoplasmic reticulum kinase (P < 0.05), activating transcription factor 6 (P < 0.05), C/EBP homologous protein (CHOP; P < 0.05), inositol-requiring enzyme 1α (P < 0.05), tumor necrosis factor-associated factor 2 (P < 0.05), activating transcription factor 6 (ATF6; P < 0.05) and apoptosis signal-regulating kinase 1 (P < 0.05) in cells, whereas Se addition reversed these changes. The exposure to Hg considerably boosted the expression of ATF6 and CHOP protein (P < 0.05), while Se addition significantly alleviated above-mentioned enhancements (P < 0.05). In summary, Hg exposure induced apoptosis, which was considerably reduced alleviated by Se addition, which was linked to the ATF6/CHOP pathway in follicular granulosa cells in laying hens.
Improving access to assessments of early motor development in local languages: Polish adaptation of the Early Motor Questionnaire
Authors: Laudańska Zuzanna , Szmytke Magdalena , Radkowska Alicja , Malinowska-Korczak Anna , Babis Karolina , Pérez David López , Tomalski Przemysław 
Published: October 2022

Abstract
A child’s motor development progresses very dynamically. It is crucial to develop freely available parent-report measures of motor development that can be easily used globally to measure motor skills and identify children in need of interventions. Here, we present the adaptation and validation of the Early Motor Questionnaire, which consists of gross motor (GM), fine motor (FM), and perception-action integration (PA) subscales, to the Polish language (EMQ-PL). In Study 1 (online, N = 640), we observed its excellent psychometric properties and significant differences in GM and Total age-independent scores between children that were and were not referred for physiotherapy. In Study 2 (in-person assessment, longitudinal, N = 100), we show high correlations of GM and total scores with Alberta Infant Motor Scale. Overall, we show that the EMQ can be easily adapted to local languages and has h a potential for use as a screening tool.
Boosting intra-African trade performance: the role of maritime transport
Authors: Ayesu Enock Kojo 
Published: October 2022

Abstract
Maritime transport significantly affects virtually all aspects of international trade globally. Following this, it becomes imperative to understand the positive influence of maritime transport in the improvement of intra-African trade performance. This paper, therefore, investigates the extent to which maritime transport boosts intra-African trade performance within the framework of the gravity model in a sample of 32 African countries for the period 2010–2018. The paper reveals that maritime transports enhance intra-African trade performance; greater access to maritime transports is associated with an increase in intra-African trade performance. Based on this outcome, it is recommended that policies that increases maritime transports are what policy makers should prioritize and pursue.
JEL Codes: C33; F10; I30; O55.
Prevalence of unmet health care need in older adults in 83 countries – measuring progressing towards universal health coverage in the context of global population ageing.
Authors: Kowal Paul , Corso Barbara , Anindya Kanya , Andrade Flavia C.D. , Giang Thanh Long , Guitierrez Maria Teresa Calzada , Pothisiri Wiraporn , Quashie Nekehia T. , Reina Herney Alonso Rengifo , Rosenberg Megumi , Towers Andy , Vicerra Paolo Miguel Manalang , Minicuci Nadia , Ng Nawi , Byles Julie 
Published: October 2022

Abstract
Current measures for monitoring progress towards universal health coverage (UHC) do not adequately account for populations that do not have the same level of access to quality care services and/or financial protection to cover health expenses for when care is accessed. This gap in accounting for unmet health care needs may contribute to underutilization of needed services or widening inequalities. Asking people whether or not their needs for health care have been met, as part of a household survey, is a pragmatic way of capturing this information. This analysis examined responses to self-reported questions about unmet need asked as part of 17 health, social and economic surveys conducted between 2001 and 2019, representing 83 low-, middle- and high-income countries. Noting the large variation in questions and response categories, the results point to low levels (less than 2%) of unmet need reported in adults aged 60 + years in countries like Andorra, Qatar, Republic of Korea, Slovenia, Thailand and Viet Nam to rates of over 50% in Georgia, Haiti, Morocco, Rwanda, and Zimbabwe. While unique, these estimates are likely underestimates, and do not begin to address issues of poor quality of care as a barrier or contributing to unmet need in those who were able to access care. Monitoring progress towards UHC will need to incorporate estimates of unmet need if we are to reach universality and reduce health inequalities in older populations.
A rare metastatic mesenteric malignant PEComa with TSC2 mutation treated with palliative surgical resection and nab-sirolimus: A case report
Authors: Meredith Luke , Chao Timothy , Nevler Avinoam , Basu-Mallick Atrayee , Singla Rajan K. , McCue Peter A. , Bowne Wilbur B. , Jiang Wei 
Published: October 2022

Abstract
Background

Malignant perivascular epithelioid cell tumors (PEComas) are exceedingly rare mesenchymal malignant neoplasms with characteristic morphological and immunohistochemical (IHC) patterns. However, some malignant PEComas are particularly poorly differentiated and may demonstrate atypical histopathological findings, making a definitive diagnosis difficult. PEComas are most commonly found in females and often show either TSC1/2 alterations, which result in the activation of the mTOR pathway, or TFE3 fusions. Given these molecular characteristics, mTOR inhibitors have recently proven useful in the treatment of malignant PEComas, particularly in those with TSC1/2 alterations. Therefore, molecular analyses may be helpful for both the diagnostic workup of and predicting response to mTOR inhibitors in cases of malignant PEComas.

Case Presentation

Here, we report a case of an aggressive, 23 cm mesenteric malignant PEComa with multiple peritoneal metastases in a young male patient. Pathological examination of the initial biopsy showed a malignant epithelioid neoplasm whose high-grade morphology and atypical immunohistochemical (IHC) reactivity precluded a definitive diagnosis. Because of the patient’s excessive transfusion requirements due to intra-tumoral hemorrhage, a palliative R2 resection was performed. Histopathological examination of the tumor revealed focal immunoreactivity for CD117, Melan-A, HMB-45, and desmin. Although a diagnosis of malignant PEComa was favored, other entities such as epithelioid gastrointestinal stromal tumor (GIST) or melanoma could not be definitively ruled out. Given the favored diagnosis, the patient was started on sirolimus, an mTOR inhibitor, rather than chemotherapy. Molecular analyses were then performed and the tumor was found to harbor mutations in TP53 and TSC2, supporting a definitive diagnosis of malignant PEComa. The patient was then switched to nab-sirolimus, with initial stabilization of the disease.

Conclusions

This report details a multi-disciplinary approach for the diagnosis and management of a highly aggressive, metastatic malignant PEComa in a young male patient. The basis for the treatment of malignant PEComas with the recently FDA-approved mTOR inhibitor, nab-sirolimus, is also reviewed. In summary, this case highlights the importance of molecular analysis, particularly TSC1/2 alterations, for both the definitive diagnosis of malignant PEComas and predicting their response to nab-sirolimus.
Impact of Double Taxation Treaties on FDI flows: an application by Centrality
Authors: Ly Alpha 
Published: October 2022

Abstract
The objective of this study is to analyse the impact of double taxation treaties (DTTs), or tax treaties, on foreign direct investment (FDI) flows. We distinguish between inflows and outflows and between volume flows and flows as a percentage of GDP. Using the GMM system estimator of \cite{blundell1998initial} on a panel of 188 developed, emerging and developing countries, covering a relatively long period of 28 years (1990-2017), we show that DTTs, summarised by the country centrality index, positively and significantly influence FDI inflows. This result remains verified when considering FDI outflows, although the short-run effect decreases in magnitude. Also, considering flows as a percentage of GDP, or changing the measure of centrality, does not qualitatively affect these results. Moreover, the magnitude of this effect evolves following the geographical areas considered and the absorption capacity of the destination countries.
JEL: F21, C45, H71
Prevalence of back pain and headache after spinal anesthesia for cesarean section compared to general anesthesia
Authors: Rakmani Najwa , Olwan Rama , Alkhalaf Shahad 
Published: October 2022

Abstract
Background
Cesarean section is the most frequent surgery in obstetrics. Common types of anesthesia done in CS are regional and general, which aim to insure the well being of the fetus and the mother and alleviate the pain in surgery as much as possible. In our study, we aim to investigate the prevalence of headache and back pain after regional anesthesia compared to general anesthesia.
Methods
A cross sectional study involving 279 patients who were admitted to Alzahrawi hospital and had undergone CS
Results
The sample in our study consisted of 279 patients, whose average age was 30.07 years; the majority of these patients had undergone regional anesthesia (82%); the remaining patients had undergone general anesthesia (18%). We did not find a statistically significant relationship between patients' headache and back pain and the type of anesthesia (P > 0.05); however, there was a statistically significant relationship between the procedures used during the procedure and the type of anesthesia.
Conclusion
Our study has shown that there’s no link between the anesthetic procedure and occurrence of back pain and headaches, eventhough most of the participants have gotten regional anesthesia.
Visualization and Analysis of RecurrentGeometric Network oriented to Protein 3DStructure Prediction
Authors: Ye Kang , Gao Ruibo 
Published: October 2022

Abstract
Recurrent geometric network(RGN) as a deep learning model have been successfully applied to predict protein 3D structure and achieved better results than conventional methods. However, because of the inter- nal complexity and nonlinear structure of deep neural networks, the underlying processes why the model achieving such performance is challenging and sometimes difficult to explain. In this paper, for pro- tein 3D structure prediction tasks, we analyze these hidden states of recurrent geometric network from a new perspective. Firstly, a method is proposed to explain network position characteristic by searching for the most similar amino acids near the selected amino acids net- work. We also analyze the update response of new neurons in forward and backward networks to further focus on the position characteris- tics of hidden state. Then, a superimposed visualization method is put forward to study which and when neurons in bidirectional net- works have a greater influence on the prediction results. Finally, we adopt comparison method for torsion angles to analyze how the back- ward neuron affects the final prediction results. The usability and effectiveness of our method are demonstrated through case studies.