bluuebunny/crossref_metadata_2025_split huggingface dataset:
Iterative algorithms for reducing inversion of discrete algebraic riccati matrix equation
Authors: Liu Jianzhou , Wang Zheng , Xie Zhiming , Wang Li 
Published: September 2022

Abstract
In practical engineering, many control problems usually can be transformed into solutions of the discrete algebraic Riccati equation (DARE), which has two matrix inverse operations formally. In this paper, first, by the relationship between properties of the matrix Schur complement and partitioned representation of inverse matrix, we change the DARE with twice inversions into an equivalent form with once inversion and propose a corresponding iterative algorithm. Next, for a special case of DARE, we deformed this DARE into a new equivalent one. For the equivalent form, we propose a new iterative algorithm in an inversion-free way. Furthermore, for these algorithms, we prove their monotone convergence and give the analysis of their errors. Last, comparing with some existing work on this topic, corresponding numerical examples are given to illustrate the superiority and effectiveness of our results.
Investigation of the strength of concrete-like material with waste rock and aeolian sand as aggregate by machine learning
Authors: Hu Yafei , Li Keqing , Zhang Bo , Han Bin 
Published: September 2022

Abstract
Solid waste filling is an important development direction for filling mining technology. This paper proposes to use waste rock and aeolian sand as aggregates to fill the underground extraction area in order to reduce the environmental damage of related waste solid. The experiments are optimized by response surface methodology and multivariate nonlinear response models are constructed to investigate the effects of different factors on uniaxial compressive strength (UCS) of concrete-like material (CLM). The performance of different swarm intelligence optimization algorithms is analyzed and combined with support vector regression model (SVR) to construct an intelligent prediction model for UCS. The results show that the packing density has a maximum value of 0.74 when the proportion of waste rock is around 0.6. The response model constructed in this paper has a P-value &lt; 0.01 and R2 &gt; 0.8, which indicates its high significance and goodness of fit. The UCS of CLM increases with the increase of cement content and slurry mass fraction, while it also increases and then decreases with the increase of proportion of waste rock. The ratio of waste rock and aeolian sand will affect the compactness of cemented structure. The better the ratio, the higher the average grey value of the cemented structure, the more compactness the cemented structure. The whale optimization algorithm-SVR model constructed in this paper has a prediction accuracy of more than 99% for UCS of CLM, which achieves high accuracy and fast prediction of UCS under multifactor conditions.
International Law and the Securitisation of Peacemaking: On Chapter VII, the Security Council and the Mediation Mandate in Yemen
Authors: Turner Catherine 
Published: September 2022

Abstract
Peace mediation as a form of peaceful settlement of disputes has evolved significantly in the past 20 years, moving away from an informal process between parties towards a more structured undertaking rooted in norms and values of international law. Sitting between Chapter VI and Chapter VII of the UN Charter, mediation is an underexplored aspect of the collective security regime in international law. Surprisingly little attention has been paid to the role of the UN Security Council (UNSC) and the exercise of legal authority under Chapter VII in shaping mediation mandates. This article addresses this gap by developing a theoretical framework for understanding the role of UNSC in the construction of security in the context of peacemaking. Using the mandate of the Office of the Special Envoy for Yemen as a case study, the article traces the progression of the mediation mandate a set out in the UNSC resolutions, interrogating the shift in discourse from UN support for an inclusive political transition into a narrower focus on hard security and the international response to the threat of terrorism. Through this analysis the article demonstrates how the place of UNSC within the Charter system allows for a gradual securitisation of the peace mediation process at the expense of inclusive approaches. At a time when consensus on collective security appears to be weakening the role of the UNSC in constructing and responding to global threats is of significant interest to the future of Charter-based international peace and security.
Inside-out planet formation – VII. Astrochemical models of protoplanetary discs and implications for planetary compositions
Authors: Cevallos Soto Arturo , Tan Jonathan C , Hu Xiao , Hsu Chia-Jung , Walsh Catherine 
Published: September 2022

ABSTRACT
Inside-out planet formation (IOPF) proposes that the abundant systems of close-in Super-Earths and Mini-Neptunes form in situ at the pressure maximum associated with the dead zone inner boundary (DZIB). We present a model of physical and chemical evolution of protoplanetary disc midplanes that follows gas advection, radial drift of pebbles, and gas-grain chemistry to predict abundances from ∼300 au down to the DZIB near 0.2 au. We consider typical disc properties relevant for IOPF, i.e. accretion rates $10^{-9}\lt \dot{m}/ (\mathrm{ M}_\odot \:{\rm {yr}}^{-1})\lt 10^{-8}$ and viscosity parameter α = 10−4, and evolve for fiducial duration of 105 yr. For outer, cool disc regions, we find that C and up to $90{{\ \rm per\ cent}}$ of O nuclei start locked in CO and $\rm O_2$ ice, which keeps abundances of $\rm CO_2$ and $\rm H_2O$ one order of magnitude lower. Radial drift of icy pebbles is influential, with gas-phase abundances of volatiles enhanced up to two orders of magnitude at icelines, while the outer disc becomes depleted of dust. Discs with decreasing accretion rates gradually cool, which draws in icelines closer to the star. At ≲ 1 au, advective models yield water-rich gas with C/O ratios ≲ 0.1, which may be inherited by atmospheres of planets forming here via IOPF. For planetary interiors built by pebble accretion, IOPF predicts volatile-poor compositions. However, advectively enhanced volatile mass fractions of $\sim 10{{\ \rm per\ cent}}$ can occur at the water iceline.
Coemergence of the Amphipathic Helix on Ameloblastin With Mammalian Prismatic Enamel
Authors: Su Jingtan , Bapat Rucha Arun , Visakan Gayathri , Moradian-Oldak Janet 
Published: September 2022

AbstractTo investigate correlation between the ameloblastin (Ambn) amino acid sequence and the emergence of prismatic enamel, a notable event in the evolution of ectodermal hard tissues, we analyzed Ambn sequences of 53 species for which enamel microstructures have been previously reported. We found that a potential amphipathic helix (AH) within the sequence encoded by Exon 5 of Ambn appeared in species with prismatic enamel, with a few exceptions. We studied this correlation by investigating synthetic peptides from different species. A blue shift in fluorescence spectroscopy suggested that the peptides derived from mammalian Ambn interacted with liposomes. A downward shift at 222 nm in circular dichroism spectroscopy of the peptides in the presence of liposomes suggested that the peptides of mammals with prismatic enamel underwent a transition from disordered to helical structure. The peptides of species without prismatic enamel did not show similar secondary structural changes in the presence of liposomes. Peptides of mammals with prismatic enamel caused liposome leakage and inhibited LS8 and ALC cell spreading regulated by full-length Ambn. RT-PCR showed that AH is involved in Ambn’s regulation of cell polarization genes: Vangl2, Vangl1, Prickle1, ROCK1, ROCK2, and Par3. Our comprehensive sequence analysis clearly demonstrates that AH motif is closely related to the emergence of enamel prismatic structure, providing insight into the evolution of complex enamel microstructure. We speculate that the AH motif evolved in mammals to interact with cell membrane, triggering signaling pathways required for specific changes in cell morphology associated with the formation of enamel prismatic structure.
Disability and Work During the Industrial Revolution in Britain
Authors: Blackie Daniel 
Published: September 2022

Abstract
A common claim in disability studies is that industrialization has marginalized disabled people by limiting their access to paid employment. This claim is empirically weak and rests on simplified accounts of industrialization. Use of the British coal industry during the period 1780–1880 as a case study shows that reassessment of the effect of the Industrial Revolution is in order. The Industrial Revolution was not as detrimental to the lives of disabled people as has often been assumed. While utopian workplaces for disabled people hardly existed, industrial sites of work did accommodate quite a large number of workers with impairments. More attention therefore needs to be paid to neglected or marginalized features of industrial development in the theorization of disability. Drawing on historical research on disability in the industrial workplace will help scholars better understand the significance of industrialization to the lives of disabled people, both in the past and the present.
Institutions for People with Disabilities in North America
Authors: Noll Steven 
Published: September 2022

Abstract
The institution or asylum in North America was established as a mechanism for confining, controlling, and containing groups of individuals classified and labeled as mentally ill or intellectually disabled and defined as deviant, defective, or delinquent. These congregate facilities, established both for the protection of the individuals housed there and for the simultaneous protection of society from those same people, developed into massive structures designed to accommodate thousands of residents/patients/inmates. The rationale behind the rapid rise of the institution throughout the nineteenth and into the mid-twentieth centuries paralleled the growth of modern medicine and psychiatry. By the 1950s, institutions housed hundreds of thousands of individuals. Yet by the start of the twenty-first century, the institutional model had been intellectually discredited, and these facilities had been all but abandoned. This rather astounding demise mirrored broader social, scientific, and medical trends.
Polio and Disability in Cold War Hungary
Authors: Vargha Dora 
Published: September 2022

Abstract
Concerns over children’s physical health and ability were shared experiences across post–World War II societies, and the figure of the child was often used as a tool to reach over the Iron Curtain. However, key differences in how children with polio were perceived, and as a result treated, followed Cold War fault lines. Concepts of an individual’s role in society shaped medical treatment and views of disability, which contributed to the celebrated polio child in one environment and her invisibility in another. Thus, through the lens of disability, new perspectives have emerged on the history of the Cold War, polio, and childhood.
Disability in Modern Chinese Cinema
Authors: Riep Steven L. 
Published: September 2022

Abstract
Depictions of disability in Chinese-language films from China and Taiwan, once a rarity, have become mainstream since the 1980s and have shifted from critiquing national policies, historical accounts, and collective experiences to highlighting disabled people as complex characters and advocating for greater support for them. These films reveal how disability has become a positive source of identity in its own right. Films from the late 1980s and early 1990s such as Tian Zhuangzhuang’s The Blue Kite use disability to offer critiques of official policies or alternative accounts of historical events. Zhou Sun’s Breaking the Silence and Xue Xiaolu’s Ocean Heaven, which focus on caregiving parents and their disabled children, reveal the need for private, extragovernmental networks of support as well as greater government support for those with disabilities and their families. Finally, films such as Zhang Yimou’s Happy Times feature characters with impairments living rich and rewarding lives, countering stereotypes about disability.
The Disability Rights Movement in the United States
Authors: Patterson Lindsey 
Published: September 2022

Abstract
Contrary to the traditional notion that disability rights in the United States were the by-product of the tumultuous 1960s, the disability rights movement actually dates back to the late nineteenth century. Over the years, ordinary citizens and local, national, and international organizations combined in promoting the citizenship rights of disabled people. Excluded from most aspects of public life, people with disabilities championed self-determination through deinstitutionalization, the independent living movement, and access to education, employment, and public transportation. This examination of local, state, and national efforts by people with disabilities to achieve full participation in civic life will help expand our understanding of civil rights movements in modern U.S. history.
Dissection of cellular and molecular mechanisms of aristolochic acid-induced hepatotoxicity via single-cell transcriptomics
Authors: Luo Piao , Chen Jiayun , Zhang Qian , Xia Fei , Wang Chen , Bai Yunmeng , Tang Huan , Liu Dandan , Gu Liwei , Du Qingfeng , Xiao Wei , Yang Chuanbin , Wang Jigang 
Published: September 2022

Abstract

Background
Aristolochic acids (AAs), a class of carcinogenic and mutagenic natural products from Aristolochia and Asarum plants, are well-known to be responsible for inducing nephrotoxicity and urothelial carcinoma. Recently, accumulating evidence suggests that exposure to AAs could also induce hepatotoxicity and even hepatocellular carcinoma, though the mechanisms are poorly defined.

Methods
Here, we aimed to dissect the underlying cellular and molecular mechanisms of aristolochic acid I (AAI)-induced hepatotoxicity by using advanced single-cell RNA sequencing (scRNA-seq) and proteomics techniques. We established the first single-cell atlas of mouse livers in response to AAI.

Results
In hepatocytes, our results indicated that AAI activated NF-κB and STAT3 signaling pathways, which may contribute to the inflammatory response and apoptosis. In liver sinusoidal endothelial cells (LSECs), AAI activated multiple oxidative stress and inflammatory associated signaling pathways and induced apoptosis. Importantly, AAI induced infiltration of cytotoxic T cells and activation of proinflammatory macrophage and neutrophil cells in the liver to produce inflammatory cytokines to aggravate inflammation.

Conclusions
Collectively, our study provides novel knowledge of AAs-induced molecular characteristics of hepatotoxicity at a single-cell level and suggests future treatment options for AAs associated hepatotoxicity.
SALT OVERLY SENSITIVE 1 is inhibited by clade D Protein phosphatase 2C D6 and D7 in Arabidopsis thaliana
Authors: Fu Haiqi , Yu Xiang , Jiang Yuanyuan , Wang Yuhan , Yang Yongqing , Chen She , Chen Qijun , Guo Yan 
Published: September 2022

Abstract
The salt overly sensitive (SOS) pathway is essential for maintaining sodium ion homeostasis in plants. This conserved pathway is activated by a calcium signaling-dependent phosphorylation cascade. However, the identity of the phosphatases and their regulatory mechanisms that would deactivate the SOS pathway remain unclear. In this study, we demonstrate that PP2C.D6 and PP2C.D7, which belong to clade D of the protein phosphatase 2C (PP2C) subfamily in Arabidopsis thaliana, directly interact with SOS1 and inhibit its Na+/H+ antiporter activity under non-salt-stress conditions. Upon salt stress, SOS3-LIKE CALCIUM-BINDING PROTEIN8 (SCaBP8), a member of the SOS pathway, interacts with the PP2Cs and suppresses their phosphatase activity; simultaneously, SCaBP8 regulates the subcellular localization of PP2C.D6 by releasing it from the plasma membrane. Thus, we identified two negative regulators of the SOS pathway that repress SOS1 activity under nonstress conditions. These processes set the stage for the activation of SOS1 by the kinase SOS2 to achieve plant salt tolerance. Our results suggest that reversible phosphorylation/dephosphorylation is crucial for the regulation of the SOS pathway, and that calcium sensors play dual roles in activating/deactivating SOS2 and PP2C phosphatases under salt stress.
Phylogenomics shows unique traits in Noctilucales are derived rather than ancestral
Authors: Cooney Elizabeth C , Leander Brian S , Keeling Patrick J 
Published: September 2022

Abstract
Dinoflagellates are a diverse protist group possessing many unique traits. These include (but are not limited to) expansive genomes packaged into permanently condensed chromosomes, photosynthetic or cryptic plastids acquired vertically or horizontally in serial endosymbioses, and a ruffle-like transverse flagellum attached along its length to the cell. When reconstructing character evolution, early branching lineages with unusual features that distinguish them from the rest of the group have proven useful for inferring ancestral states. The Noctilucales are one such lineage, possessing relaxed chromosomes in some life stages and a trailing, thread-like transverse flagellum. However, most of the cellular and molecular data for the entire group come from a single cultured species, Noctiluca scintillans, and because its phylogenetic position is unresolved it remains unclear if these traits are ancestral or derived. Here, we use single cell transcriptomics to characterize three diverse Noctilucales genera: Spatulodinium, Kofoidinium, and a new lineage, Fabadinium gen. nov. We also provide transcriptomes for undescribed species in Amphidinium and Abediniales, critical taxa for clarifying the phylogenetic position of Noctilucales. Phylogenomic analyses suggests that the Noctilucales are sister to Amphidinium rather than an independent branch outside the core dinoflagellates. This topology is consistent with observations of shared characteristics between some members of Noctilucales and Amphidinium and provides the most compelling evidence to date that the unusual traits within this group are derived rather than ancestral. We also confirm that Spatulodinium plastids are photosynthetic and of ancestral origin, and show that all non-photosynthetic Noctilucales retain plastid genes indicating a cryptic organelle.
Liquid–liquid phase transition in deeply supercooled Stillinger–Weber silicon
Authors: Goswami Yagyik , Sastry Srikanth 
Published: September 2022

Abstract
The existence of a phase transition between two distinct liquid phases in single-component network-forming liquids (e.g. water, silica, silicon) has elicited considerable scientific interest. The challenge, both for experiments and simulations, is that the liquid–liquid phase transition (LLPT) occurs under deeply supercooled conditions, where crystallization occurs very rapidly. Thus, early evidence from numerical equation of state studies was challenged with the argument that slow spontaneous crystallization had been misinterpreted as evidence of a second liquid state. Rigorous free-energy calculations have subsequently confirmed the existence of a LLPT in some models of water, and exciting new experimental evidence has since supported these computational results. Similar results have so far not been found for silicon. Here, we present results from free-energy calculations performed for silicon modeled with the classical, empirical Stillinger-Weber–potential. Through a careful study employing state-of-the-art constrained simulation protocols and numerous checks for thermodynamic consistency, we find that there are two distinct metastable liquid states and a phase transition. Our results resolve a long-standing debate concerning the existence of a liquid–liquid transition in supercooled liquid silicon and address key questions regarding the nature of the phase transition and the associated critical point.
Cell-type-specific genes associated with cortical structural abnormalities in pediatric bipolar disorder
Authors: Lei Wenkun , Xiao Qian , Wang Chun , Gao Weijia , Xiao Yiwen , Dai Yingliang , Lu Guangming , Su Linyan , Zhong Yuan 
Published: September 2022

Abstracts

Background
Pediatric bipolar disorder (PBD) has been proven to be related to abnormal brain structural connectivity, but how the abnormalities in PBD correlate with gene expression is debated.

Objective
This study aims at identification of cell-type-specific gene modules based on cortical structural differences in PBD.

Methods
Morphometric similarity networks (MSN) were computed as a marker of interareal cortical connectivity based on MRI data from 102 participants (59 patients and 43 controls). Partial least squares (PLS) regression was used to calculate MSN differences related to transcriptomic data in AHBA. The biological processes and cortical cell types associated with this gene expression profile were determined by gene enrichment tools.

Results
MSN analysis results demonstrated differences of cortical structure between individuals diagnosed with PBD and healthy control participants. MSN differences were spatially correlated with the PBD-related weighted genes. The weighted genes were enriched for “trans-synaptic signaling” and “regulation of ion transport”, and showed significant specific expression in excitatory and inhibitory neurons.

Conclusions
This study identified the genes that contributed to structural network aberrations in PBD. It was found that transcriptional changes of excitatory and inhibitory neurons might be associated with abnormal brain structural connectivity in PBD.
SUBSTANTIAL EXTERNAL DOSE RATE VARIABILITY OBSERVED IN A COHORT OF LU-177 PATIENTS INDEPENDENT OF BMI AND SEX
Authors: Bellamy Michael , Chu Bae , Serencsits Brian , Quinn Brian , Prasad K , Altamirano J , Williamson Matthew , Miodownik Daniel , Abrahams Natalie , Chen Fanny , Bierman David , Wutkowski M , Dauer Lawrence 
Published: September 2022

Abstract
External dose rates were measured 1 m away from 230 Lu-177 patients to characterise the variability in normalised dose rates as a function of administered activity, body mass index (BMI) and sex. The largest dose rate observed was 0.07 mSv/h associated with an administered activity of 7.2 GBq. Substantial variability was found in the distribution of the normalised dose rate associated that had an average of 0.0037 mSv/h per GBq and a 95% confidence interval of 0.0024–0.0058 mSv/h per GBq. Based on this study, estimating the patient dose rate based on the Lu-177 gamma exposure factor overestimates the dose rate by a factor of 2. A statistically significant inverse relationship was found between the patient dose rate and patient BMI and an empirically derived equation relating these two quantities was reported. On average, male patient dose rates were 3.5% lower than female dose rates, which may be attributed to the larger average BMI of the male patient group.