bluuebunny/crossref_metadata_2025_split huggingface dataset:
Managing repugnance: how core-stigma shapes firm behavior
Authors: Dekker Erwin , Gradoz Julien 
Published: November 2022

AbstractThis article argues for the need for the empirical analysis of how firms manage repugnance and core-stigmatization. To develop our empirical perspective, we compare the work on repugnance with the existing empirical literature in management on core-stigma and argue that core-stigmatization results from the mobilized repugnance. The core-stigmatized firm faces higher transaction costs. We demonstrate, through a case-study of the strategies of MindGeek/Pornhub in the online pornography market, how transaction costs economics can explain the choice of strategies to deal with core-stigma. Under most conditions, the increased transaction costs lead to vertical and lateral integration of the firm. In a dynamic setting, rival firms might use stigmatization to prevent the entry of a new competitor. Our second case-study on the early decades of the mail-order company Sears, Roebuck, and Company illustrates that repugnance, including racial discrimination, was mobilized by competitors to block the entry of the firm into the market.
Automated assessment of infant motor development to predict infant age: The determination of objective metrics of spontaneous kicking
Authors: Fry-Hilderbrand Katelyn , Chen Yu-Ping , Howard Ayanna 
Published: November 2022

Abstract
Though early intervention can improve outcomes for children with motor disabilities, delays in diagnosis can impact the success of intervention programs. Prior work indicates that spontaneous kicking patterns can be used to model typical infant motor development to assist in the early detection of motor delays. However, abnormalities in spontaneous movements are not well defined or readily observable through traditional functional assessments. In this research, a method is introduced for the early detection of delays through the assessment of spontaneous kicking data gathered using a wearable sensing suit. We present formulations of kinematic features identified in the clinical space, identify which features are significant predictors of infant age, and establish normative values. Finally, we offer an analysis of preterm (PT) infant data compared to normative values derived from term infants. Term and PT infants ranging in age from 1 to 10 months were studied. We found that frequency, duration, acceleration, inter-joint coordination, and maximum joint excursion metrics had a significant correlation with age. From these features, models of typical kicking development were created using data from term, typically developing infants. When compared to normative trends, PT infants display differing developmental trends.
Understanding the Structural Components Behind the Psychological	Effects of Autonomous Sensory Meridian Response (ASMR) With Machine Learning and	Experimental Methods
Authors: Tan Ryan , Shoenberger Heather , Cong Weilin , Mahdavi Mehrdad 
Published: November 2022

Abstract: Autonomous sensory meridian response (ASMR) is a tingling sensation occurring in response to specific sensory stimuli. Scholarship has yet to investigate what attributes these stimuli possess that allows them to facilitate desirable emotional effects through such atypical psycho-sensorial experiences. In this exploratory investigation, Study 1 utilized machine learning methods to categorize ASMR content based on their sound structures. Four categories emerged that were then used in a second study that utilized an online experiment ( N = 230) to investigate relationships between the categories of sound structures and participants’ psychological experiences of ASMR. These findings help us understand how ASMR content generates arousal and affect that audiences seek.
Diverging Fates of the Pacific Ocean Oxygen Minimum Zone and Its Core in a Warming World
Authors: Busecke Julius J. M. , Resplandy Laure , Ditkovsky Sam J. , John Jasmin G. 
Published: November 2022

AbstractGlobal ocean oxygen loss is projected to persist in the future, but Earth system models (ESMs) have not yet provided a consistent picture of how it will influence the largest oxygen minimum zone (OMZ) in the tropical Pacific. We examine the change in the Pacific OMZ volume in an ensemble of ESMs from the CMIP6 archive, considering a broad range of oxygen (O2) thresholds relevant to biogeochemical cycles and ecosystems (5–160 µmol/kg). Despite OMZ biases in the historical period of the simulations, the ESM ensemble projections consistently fall into three regimes across ESMs: an expansion of low oxygenated waters (+0.8 [0.6, 1.0] × 1016 m3/century for O2 ≤ 120 µmol/kg, ESM median and interquartile range); a slight contraction of the OMZ core although more uncertain across ESMs (−0.1 [−0.5, 0.0] × 1016 m3/century for O2 ≤ 20 µmol/kg); and at the transition from contraction to expansion regimes, a spatial redistribution but near‐zero change in the volume of hypoxic waters (0.0 [−0.3, +0.1] × 1016 m3/century for O2 ≤ 60 µmol/kg). Changes in circulation and biology dictate the shift from expansion to contraction. Specifically, reduced subtropical ventilation controls the expansion of low oxygenated waters, while a combination of circulation and biological changes explains the contraction of the core (likely changes in mixing, reduced intermediate ventilation and oxygen demand). Increased model complexity (e.g., ecosystem dynamics and equatorial circulation) likely stabilize the OMZ response, suggesting that future changes might lie in the lower bound of current projections. The expansion of low oxygenated waters which delimit the optimum habitat of numerous marine species would severely impact ecosystems and ecosystem services.
Future Seasonal Changes in Extreme Precipitation Scale With Changes in the Mean
Authors: Bador Margot , Alexander Lisa V. 
Published: November 2022

AbstractAtmospheric warming results in an intensification of annual precipitation over the globe but large uncertainties remain regionally and at seasonal scales, especially for extremes. Using 29 models from the Sixth Phase of the Coupled Model Intercomparison Project (CMIP6), we investigate future seasonal changes in extreme precipitation (under the scenario SSP5‐8.5) and how it compares to changes in mean precipitation. Over land, we find a strong intensification of the wettest day in all seasons over the mid and high latitudes of the Northern Hemisphere and over India during the monsoon. Extreme intensity decreases in the subtropics for some seasons, including over large regions around the Mediterranean basin and Southern Africa, and these drying patterns are not apparent in annual results. The key finding is that the CMIP6 multi‐model mean always shows that seasonal changes in mean and extreme precipitation align where there is high model agreement. That is, in all seasons by the end of the 21st century, extremes intensify in regions where mean precipitation increases and decline where mean precipitation decreases. This should not hide inherent uncertainties associated, namely the large range of changes intensity that can be found across the models, and an important modulation of the changes by internal variability. Yet, this study shows that the multi‐model mean shows broad consistency such that future seasonal changes in mean precipitation could be used to infer future changes in extremes (and vice versa), thus providing valuable information for risk planning and mitigation strategies.
Coordinated Observations of Migrating Tides by Multiple Meteor Radars in the Equatorial Mesosphere and Lower Thermosphere
Authors: Wang Jianyuan , Yi Wen , Wu Jianfei , Chen Tingdi , Xue Xianghui , Zeng Jie , Vincent Robert A. , Reid Iain M. , Batista Paulo P. , Buriti Ricardo A. , Tsuda Toshitaka , Mitchell Nicholas J. , Dou Xiankang 
Published: November 2022

AbstractWe present the migrating tidal winds decomposed jointly from multiple meteor radars in four longitudinal sectors situated in the equatorial mesosphere and lower thermosphere. The radars are located in Cariri, Brazil (7.4°S, 36.5°W), Kototabang, Indonesia (0.2°S, 100.3°E), Ascension Island, United Kingdom (7.9° S, 14.4° W), and Darwin, Australia (12.3°S, 130.8°E). Harmonic analysis was used to obtain amplitudes and phases for diurnal and semidiurnal solar migrating tides between 82 and 98 km altitude during the period 2005–2008. To verify the reliability of the tidal components calculated by the four meteor radar wind measurements, we also present a similar analysis for the Whole Atmosphere Community Climate Model winds, which suggests that the migrating tides are well observed by the four different radars. The tides include the important tidal components of diurnal westward‐propagating zonal wavenumber 1 and semidiurnal westward‐propagating zonal wavenumber 2. In addition, the results based on observations were compared with the Climatological Tidal Model of the Thermosphere (CTMT). In general, in terms of climatic features, our results for the major components of migrating tides are qualitatively consistent with the CTMT models derived from satellite data. In addition, the tidal amplitudes are unusually stronger in January–February 2006. This result is probably because tides were enhanced by the 2006 Northern Hemisphere stratospheric sudden warming event.
Constraints on Magma Properties at Fragmentation During the 2011 Sub‐Plinian Eruptions of Kirishima Shinmoe‐dake Volcano, Japan
Authors: Kozono Tomofumi , Okumura Satoshi 
Published: November 2022

AbstractWe investigated essential factors controlling magma fragmentation during the 2011 sub‐Plinian eruptions of Kirishima Shinmoe‐dake volcano, Japan, based on observational data and the analysis of the conduit flow system. Key observational data of the Shinmoe‐dake eruptions are geophysically estimated magma discharge rate and petrologically measured crystallinity and porosity at the time of fragmentation. Using formulations of fragmentation criterion and conduit flow model, we derived analytical expressions describing the relationship among magmatic and geological parameters at the time of strain rate‐induced or stress fragmentation. The combination of the observational data and the analytical expressions revealed the relationship among weakly constrained parameters at the fragmentation, such as pressure, gas permeability in the magma, conduit radius, and maximum packing fraction of crystals, β*. From this relationship, we found that a smaller β*, less than approximately 0.5, is necessary for the fragmentation to occur for a wide range of the conduit radii under realistic pressure and gas permeability values. This reflects that in the case of the sub‐Plinian eruption with a moderate magma discharge rate, a drastic increase in magma viscosity induced by the smaller β* plays a crucial role in the occurrence of fragmentation. The strong dependence of the fragmentation process on β* indicates that the suspension rheology of crystal‐bearing magma is an essential factor controlling the magma ascent process during the moderate explosive eruption.
Mapping of Active Frazil and Sea Ice Production in the Northern Hemisphere, With Comparison to the Southern Hemisphere
Authors: Nakata K. , Ohshima K. I. 
Published: November 2022

AbstractFrazil ice in the coastal polynyas has been increasingly recognized as important for efficient sea ice production, associated dense water formation, transport of particulate matter and consequent biological production. However, it has not been well understood where and to what degree active‐frazil areas occur in the Northern Hemisphere polynyas. We presented the first mapping of active frazil in the Northern Hemisphere, using sea ice data during September–May for 2002/2003–2010/2011, created from an Advanced Microwave Scanning Radiometer for the Earth Observing System thin ice algorithm that can detect active frazil areas. The North Water, Northeast Water, Anadyr, and St. Lawrence Island polynyas were found to have a relatively high occurrence rate of active frazil compared with other polynyas. We improved the estimation of sea ice production by discriminating between active frazil and thin solid ice and found that previous algorithms tended to overestimate sea ice production, particularly for polynyas dominated by thin solid ice such as the Okhotsk Northwestern polynya. We also made the first global comparison of polynya characteristics for all the major coastal polynyas. The annual ice production rate is 3–4 m yr−1 in the Northern Hemisphere polynyas and 6–9 m yr−1 in the Antarctic coastal polynyas. This large difference is mainly explained by the less frequent occurrence of active frazil and thin ice areas in the Northern Hemisphere polynyas owing to a lower occurrence of strong wind events.
Simple Hybrid Sea Ice Nudging Method for Improving Control Over Partitioning of Sea Ice Concentration and Thickness
Authors: Audette Alexandre , Kushner Paul J. 
Published: November 2022

AbstractTo assess the effect of ocean‐atmosphere coupling in the climate response to forced sea ice loss, the Polar Amplification Model Intercomparison Project protocol includes centennial coupled atmosphere‐ocean general circulation model simulations with imposed sea ice loss. The protocol, which specifies sea ice concentration and thickness distribution targets, does not prescribe a method for achieving them. Although different methods for imposing sea ice loss (or growth) in models have been documented, testing of the method‐dependence of the resulting climate responses has been limited. Achieving the targeted sea ice state has proven to be challenging using the so‐called ghost‐flux nudging method, which induces ice melt from below, as this method does not constrain the partitioning between thickness and concentration. We propose, describe and test a simple method that combines the advantages of direct sea ice nudging and ghost‐flux nudging. The hybrid nudging method better captures the partitioning between thickness and concentration while conserving total water content. We document how this novel sea ice constraining method reaches specific targets, enhances surface turbulent heat flux responses to sea ice loss, and induces tropospheric warming for both polar regions.
Insights Into Episodic Exhumation of the Western Tibetan Plateau Since the Late Cretaceous From Low‐Temperature Thermochronology
Authors: Xu S. Y. , Dai J. G. , Li H. A. , Liu B. R. , Han X. , Wang C. S. 
Published: November 2022

AbstractThe western Tibetan Plateau (TP) is characterized by low relief with high elevation separated by deep river valleys. When and how this characteristic topography developed remains ambiguous. Here, we present apatite (U‐Th)/He and fission‐track ages from three groups of samples with different geomorphic and geological settings. Thermal histories and exhumation rates were extracted from the thermochronological data. An early stage of exhumation (ca. 0.1 km/Ma) during 70–40 Ma was recorded by all samples, followed by slow exhumation (0.03–0.06 km/Ma) since the Eocene for the sample farthest away from faults and incised valley. The second stage of faster exhumation (ca. 0.13–0.15 km/Ma) during 30–23 Ma was revealed by samples from the hanging wall of thrust faults, whereas the third stage of exhumation during 15–12 Ma (ca. 0.1 km/Ma) was identified from samples in the Dingzi Zangbo valley. Combined with the regional geological setting, we propose that (a) the Late Cretaceous‐Early Eocene exhumation in the western TP was related to regional thrust‐induced crustal thickening and led to the formation of the proto‐TP; (b) the proto‐TP was modified by local structures and river incision. The Oligocene exhumation might be caused by local thrust activity, whereas the Miocene exhumation might be related to the transition from internal to external drainage. The continuous activity of the Karakoram fault resulted in another reorganization of drainage which led to the slow exhumation since 9 Ma. Our results highlight that tectonic and drainage network reorganization play an important role in shaping the geomorphology of the western TP.
Management of hypertensive crisis: British and Irish Hypertension Society Position document
Authors: Kulkarni Spoorthy , Glover Mark , Kapil Vikas , Abrams S. M. L. , Partridge Sarah , McCormack Terry , Sever Peter , Delles Christian , Wilkinson Ian B. 
Published: November 2022

AbstractPatients with hypertensive emergencies, malignant hypertension and acute severe hypertension are managed heterogeneously in clinical practice. Initiating anti-hypertensive therapy and setting BP goal in acute settings requires important considerations which differ slightly across various diagnoses and clinical contexts. This position paper by British and Irish Hypertension Society, aims to provide clinicians a framework for diagnosing, evaluating, and managing patients with hypertensive crisis, based on the critical appraisal of available evidence and expert opinion.
Light People: Professor Stefan Hell
Authors: Wang Hui 
Published: November 2022

Editorial“When all those around me are drunk, I alone am sober,” lamented an ancient Chinese poet on fighting a lone and helpless cause. In the world of science a few decades ago, there was also a lone researcher who pursued the field of optical resolution despite suspicions and derisions. Unlike those who made their names young, this scientist only succeeded thanks to his own perseverance. He developed the 4Pi microscope and successfully increased the vertical resolution of traditional optical microscopes by 3–7 times. Once he sold the patent to a company, he invested the little personal money gained from the patent in breaking the Abbe diffraction limit. Despite all his hard work, his papers kept getting rejected by respected journals, and his work was subjected to mistrust and even criticism. This scientist is Stefan Hell, someone who is never afraid of difficulties and ever determined to forge ahead.Hell was awarded the Nobel Prize in Chemistry in 2014 for being the first to propose and demonstrate that the optical diffraction limit can be broken, and for successfully developing the STED super-resolution fluorescence microscope. Later Hell and his colleagues proposed and commercialized MINFLUX, which brought optical microscopy technology to the three-dimensional single-nanometer scale, opening the “post-superresolution era”.Frank and sincere, persistent and humble, boldly innovative and resolute, Hell is a scientist, an entrepreneur, a mentor, and an everyday man who enjoys life.In this interview, we will reacquaint ourselves with the Nobel laureate, Stefan Hell.
Parental concern for clinically vulnerable child during first 18 months of the COVID pandemic
Authors: Driessens Corine , Mills Lynne , Culliford David , Patel Ravin , Lee Emma , Gbesemete Diane , Chappell Harry , Shaunak Meera , Faust Saul N. , de Graaf Hans ,   On behalf of the ImmunoCOVID19 study group (Appendix A)
Published: November 2022

AbstractBackgroundThe uncertainties surrounding the COVID-19 pandemic have been associated with increased parental concern. The aim of this study is to explore if this increased level of concern is associated with certain individual/household characteristics or if parents adapted to the ever-changing realities of the COVID-19 pandemic over time.MethodsThis prospective study explored COVID-19 concern trajectories and associated family characteristics of 765 UK parents caring for an immunosuppressed child during the first 18 months of the pandemic using growth mixture modelling. Qualitative analysis was performed to examine in more detail the source of concern.ResultsFour different trajectories of parental COVID-19 concern were identified. Ongoing very high concern was associated with caring for children with nephrotic or respiratory disease; having a child on an organ transplant waiting list; residency in the North of England; or parental vocational inactivity. Explicit concerns voiced by the parents generally followed national trends, but vulnerable status specific concerns were also reported.ConclusionDiagnosis and prescribed medication of the immunosuppressed child, geographical location, household composition, and employment status of parent were associated with the different concern trajectories. This information can be helpful in targeting psychological family care where it is most needed.ImpactMany British parents caring for a clinically vulnerable child during the first 18 months of the COVID-19 pandemic showed high levels of concern with little sign of psychological adaptation.Consistent with findings from non-vulnerable populations, parents mentioned the impact of shielding and repeated isolation on their child’s education, social life, and mental health.Unique to the clinically vulnerable population, parents were worried about child’s health status, impact of delayed healthcare, and were confused by the contradictory information received from government, doctors, and media.Psychological family care can be targeted to those parents at greater risk for high levels of concern.
Copper homeostasis and cuproptosis in health and disease
Authors: Chen Liyun , Min Junxia , Wang Fudi 
Published: November 2022

AbstractAs an essential micronutrient, copper is required for a wide range of physiological processes in virtually all cell types. Because the accumulation of intracellular copper can induce oxidative stress and perturbing cellular function, copper homeostasis is tightly regulated. Recent studies identified a novel copper-dependent form of cell death called cuproptosis, which is distinct from all other known pathways underlying cell death. Cuproptosis occurs via copper binding to lipoylated enzymes in the tricarboxylic acid (TCA) cycle, which leads to subsequent protein aggregation, proteotoxic stress, and ultimately cell death. Here, we summarize our current knowledge regarding copper metabolism, copper-related disease, the characteristics of cuproptosis, and the mechanisms that regulate cuproptosis. In addition, we discuss the implications of cuproptosis in the pathogenesis of various disease conditions, including Wilson’s disease, neurodegenerative diseases, and cancer, and we discuss the therapeutic potential of targeting cuproptosis.
E2F1-initiated transcription of PRSS22 promotes breast cancer metastasis by cleaving ANXA1 and activating FPR2/ERK signaling pathway
Authors: Song Lin , Li Hui , Ma Ran-Ran , Liu Sen , Zhang Guo-Hao , Guo Xiang-Yu , Zhao Rui-Nan , Wu Xiao-Juan , Zhang Kai , Gao Peng 
Published: November 2022

AbstractBreast cancer (BC) is the most common malignant tumor in women worldwide. Metastasis is the main cause of BC-related death. The specific mechanism underlying BC metastasis remains obscure. Recently, PRSS22 was discovered to be involved in tumor development, however, its detailed biological function and regulatory mechanism in BC are unclear. Here, we characterized that PRSS22 expression is upregulated in BC tissues compared with non-tumorous breast tissues. Dual luciferase assays, bioinformatics analyses and chromatin immunoprecipitation (ChIP) assays indicated that transcription factor E2F1 directly binds to the PRSS22 promoter region and activates its transcription. Functionally, upregulation of PRSS22 promoted invasion and metastasis of BC cells in vitro and in vivo, whereas knockdown of PRSS22 inhibited its function. Mechanistically, the combination of PRSS22 and ANXA1 protein in BC cells was first screened by protein mass spectrometry analysis, and then confirmed by co-immunoprecipitation (Co-IP) and western blot assays. Co-overexpression of PRSS22 and ANXA1 could promote BC cell migration and invasion. We further demonstrated that PRSS22 promotes the cleavage of ANXA1 and in turn generates an N-terminal peptide, which initiates the FPR2/ERK signaling axis to increase BC aggressiveness.