bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stereotactic Radioablation for Ventricular Tachycardia in the Setting of Electrical Storm
Authors: Ninni Sandro , Gallot-Lavallée Thomas , Klein Cédric , Longère Benjamin , Brigadeau François , Potelle Charlotte , Crop Frederik , Rault Erwann , Decoene Camille , Lacornerie Thomas , Lals Séverine , Kouakam Claude , Pontana François , Lacroix Dominique , Klug Didier , Mirabel Xavier 
Published: September 2022

Background:
Stereotactic body radiotherapy (SBRT) has been reported as a safe and efficient therapy for treating refractory ventricular tachycardia (VT) despite optimal medical treatment and catheter ablation. However, data on the use of SBRT in patients with electrical storm (ES) is lacking. The aim of this study was to assess the clinical outcomes associated with SBRT in the context of ES.

Methods:
This retrospective study included patients who underwent SBRT in the context of ES from March 2020 to March 2021 in one tertiary center (CHU Lille). The target volume was delineated according to a predefined workflow. The efficacy was assessed with the following end points: sustained VT recurrence, VT reduced with antitachycardia pacing, and implantable cardioverter defibrillator shock.

Results:

Seventeen patients underwent SBRT to treat refractory VT in the context of ES (mean 67±12.8 age, 59% presenting ischemic heart disease, mean left ventricular ejection fraction: 33.7± 9.7%). Five patients presented with ES related to incessant VT. Among these 5 patients, the time to effectiveness ranged from 1 to 7 weeks after SBRT. In the 12 remaining patients, VT recurrences occurred in 7 patients during the first 6 weeks following SBRT. After a median 12.5 (10.5–17.8) months follow-up, a significant reduction of the VT burden was observed beyond 6 weeks (−91% [95% CI, 78–103]),
P
<0.0001). The incidence of implantable cardioverter defibrillator shock and antitachycardia pacing was 36% at 1 year.

Conclusions:
SBRT is associated with a significant reduction of the VT burden in the event of an ES; however, prospective randomized control trials are needed. In patients without incessant VT, recurrences are observed in half of patients during the first 6 weeks. VT tolerance and implantable cardioverter defibrillator programming adjustments should be integrated as part of an action plan defined before SBRT for each patient.
ANGPTL3 and Cardiovascular Outcomes in Patients With Acute Coronary Syndrome and Obstructive Sleep Apnea
Authors: Lv Qianwen , Jiao Xiaolu , Yu Huahui , Sun Qiuju , Li Fan , Wang Yu , Sun Haili , Du Zhiyong , Li Linyi , Hu Chaowei , Zhang Ming , Nie Shaoping , Qin Yanwen 
Published: September 2022

Background
The aim of this prospective study was to determine the impact of elevated ANGPTL3 (angiopoietin‐like protein 3) on cardiovascular events (CVEs) following acute coronary syndrome (ACS) in patients with or without obstructive sleep apnea (OSA).

Methods and Results

A total of 1174 patients with ACS underwent successful percutaneous coronary intervention were included in this prospective cohort study (NCT03362385). Patients were categorized according to the apnea–hypopnea index (≥15 events/h, OSA) and further classified by ANGPTL3 levels. We analyzed the incidence of CVEs in patients with ACS according to the status of OSA and ANGPTL3. During a median of 3.1 years of follow‐up, 217 (18.48%) CVEs occurred. The patients with ACS with OSA had higher ANGPTL3 levels than those without OSA (30.4 [20.9–43.2] versus 27.80 [19.1–41.5] ng/mL;
P
<0.001). In all patients with ACS, 29≤ANGPTL3<42 mg/dL and ANGPTL3≥42 mg/dL were associated with an increased risk of CVEs with hazard ratios (HRs) of 1.555 (95% CI, 1.010–2.498) and 2.489 (95% CI 1.613–3.840), respectively. When the status of OSA or not was incorporated in stratifying factors, 29≤ANGPTL3<42 mg/dL and ANGPTL3≥42 mg/dL were associated with a significantly higher risk of CVEs in patients with ACS with OSA (HR, 1.916 [95% CI, 1.019–3.601] and HR, 2.692 [95% CI, 1.379–4.503]) but not without OSA. Moreover, adding ANGPTL3 to the Cox model increased C‐statistic values by 0.035 and 0.029 in the OSA group and all patients with ACS, respectively, but was not statistically improved in patients with ACS without OSA.

Conclusions
In conclusion, our study demonstrates a predictive impact of plasma ANGPTL3 on cardiovascular risk in patients with ACS, especially in patients with ACS with OSA. It might be of clinical value in refining risk stratification and tailoring treatment of patients with ACS and OSA.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03362385.
Review Article: J. W. Mealy After the Thousand Years
Authors: Beale Greg K. 
Published: September 2022

The main contention of J. W. Mealy in his book After the Thousand Years is that the nations which Satan deceives at the conclusion of the millennium have been literally resurrected. Immediately following their resurrection, they undergo a second satanic deception and rebel against Christ a second time (20:5a, 7–9). His view that the final onslaught of the evil nations in vv 7–9 is the fulfillment of the prediction of v 5a (‘the rest of dead did not come to life until the thousand years were completed’) is contrary to almost all commentators of different millennial persuasions who instead see 20:12–15 as the fulfillment of 20:5a.
Mealy's identification of vv 8–9 as the fulfillment of v 5a has one strong prima facie argument in its favor (see pp. 124–126): the phrase ‘when the thousand years were completed' of v 7 is almost identical to the phrases ‘until the thousand years were completed' of vv 3b and 5a, which respectively prophesy Satan’s release from his prison and the resurrection of all unbelievers. Therefore, it is natural to identify all three verses as discussing events which are to happen at precisely the same time. Accordingly, w 7-9 appear to develop w 3b and 5a by indicating their fulfillment. If at the end of the thousand years Satan will be loosed ( v 3b ), and if at the end of the same period the rest of the dead are to rise (v 6a), then w 7–9 must be viewed as fulfilling vv 3b and 5a. In this light it is natural to take the phrase 'they ascended' in v 9 as synonymous with ‘they came to life’ of v 5a.
Beale evaluates the exegetical underpinnings of this prima facie argument and raises a number of questions about the viability of the thesis.
Adjustment of Solid Precipitation during the Filomena Extreme Snowfall Event in Spain: From Observations to “True Precipitation”
Authors: Buisán Samuel T. , Serrano-Notivoli Roberto , Kochendorfer John , Bello-Millán Francisco J. 
Published: September 2022

Abstract
On January 2021, the heaviest snowfall in five decades hit central Spain, especially affecting Madrid. The city’s Barajas International Airport closed, along with a number of roads, and all trains to and from Madrid were cancelled. This storm was named Filomena by the Spanish Meteorological Agency (AEMET), and produced continuous snowfall in Spain on 7–10 January. The observed snow depth was around 50 cm in 24 h in Madrid, and even higher in other areas of Spain. However, the measured accumulation of national precipitation gauges was not consistent with the observed accumulated snow on the ground and with the modeled weather forecast. The undercatch of solid precipitation was the primary reason for this inconsistency. This undercatch was quantified using transfer functions developed from the World Meteorological Organization (WMO) Solid Precipitation Intercomparison Experiment (SPICE). Results show that an underestimation of 20%–30% of solid precipitation in large areas of Spain was observed, with some areas experiencing even larger differences. Without adjustments, it was impossible to accurately validate the model forecast. The adjusted precipitation was also more realistically distributed, and it was more consistent with all the damage that occurred. The same methods can be applied to other snowfall events occurring anywhere in the world, and also using different precipitation gauges and/or models. This an example of the type of extreme events that modelers, forecasters, and climatologists should be aware of to avoid misinterpreting differences between modeled precipitation, observed precipitation, and nowcasting.
Equity Efforts as Boundary Work: How Symbolic and Social Boundaries Shape Access and Inclusion in Graduate Education
Authors: Posselt Julie , Reyes Kimberly A. , Slay Kelly E. , Kamimura Aurora , Porter Kamaria B. 
Published: September 2022

Background/Context Education scholars have examined how state policy and informal practice can widen or reproduce racial and gender inequalities in graduate education. Just one empirical study, which focused on psychology programs, has identified organizational practice that supports recruitment and retention of graduate students of color. Focus of Study To identify organizational conditions and specific activities that support diversity in STEM graduate programs, the authors conducted a yearlong case study of a physics program that, for the last decade, has trained about 10% of the Black Ph.D.s in physics, nationally. They identified and described concrete efforts to enhance access and inclusion, and sought to understand how this program distinguished itself from a traditional physics department. Participants Study participants consisted of 16 faculty, administrators, administrative staff, and students affiliated with the Applied Physics program at the University of Michigan. Research Design Data for this qualitative case study was collected through eighteen interviews, two student focus groups, observations of everyday life and special events in the program, and a large amount of documentary data. Guided by the constant comparative method, the analysis assessed convergence and divergence across types of data and across faculty, administrator, staff, and student perspectives. Major findings represent four areas of consensus across participant roles. Findings/Results Four themes explain how Applied Physics has increased access to and inclusion in a field known for its inequality. The program institutionalized a flexible, interdisciplinary intellectual paradigm; they reconceputalized their vision of the ideal student and reformed admissions accordingly; they empowered administrative staff to serve as cultural translators across racial and faculty-student boundaries; and they worked to create a familylike climate that gave them a competitive advantage over other physics programs. Conclusions/Recommendations We interpret the findings from the perspective of Charles Tilly's boundary change mechanisms, and conclude that the common thread among the four themes was the program's willingness to erase, relocate, and/or deactivate boundaries that had implicitly created barriers to access and inclusion for underrepresented students. The paper recommends specific steps that graduate programs can take to analyze the symbolic boundaries operating in their own programs, and invites scholars to utilize the boundaries perspective in future research on educational inequality.
Weight changes after first-line antiretroviral initiation in a cohort of HIV-positive patients in Southern Spain (CAPOTA study)
Authors: Gómez-Ayerbe Cristina , Palacios Rosario , Mayorga Marisa , Navarrete Miguel Nicolas , Ferra Sergio , Ruiz Inmaculada , Garcia Coral , Castaño Manuel , Merino Dolores , Collado Antonio , Hidalgo-Tenorio Carmen , Delgado Marcial , Rivero Antonio , Santos Jesús 
Published: September 2022

Background Obesity among persons living with HIV (PLWH) has increased and weight gain after antiretroviral therapy (ART) can lead to metabolic disorders and impact survival. Our objective was to analyze weight and metabolic changes in HIV näive patients after 48 weeks of ART. Methods Observational, retrospective, multicentered cohort study comprising naïve-patients who started tenofovir alafenamide/emtricitabine/elvitegravir/cobicistat (TAF/FTC/EVG/c) or abacavir/lamivudine/dolutegravir (ABC/3TC/DTG), with no change in treatment for 48 weeks. Clinical and metabolic parameters were collected at baseline and week-48. Statistical program used was SPSS 21.0.0. Results The study included 329 participants from 6 hospitals. Participants were 89% male and 10% had AIDS diagnosis. Median age was 35 (IQR 27–43) years. Median baseline CD4 count was 417 (IQR 250–569) cell/mm3 and HIV viral load 4.65 (IQR 4.21–5.18) log10 copies/ml. Baseline median weight was 70 (IQR 62–79) kg, body mass index 23.4 (IQR 21.2–26.0) kg/m2; 22.7% overweight and 6.4% obese. ART regimens: ABC/3TC/DTG (196), TAF/FTC/EVG/c (133). Baseline characteristics were similar in both ART groups. Average weight gain at week-48 was 2.9 (SD 5.5) kg ( p < 0.0001) with no differences between both groups. There was an increase in obesity (6.4%–8%; p < 0.003) and overweight (22.7%–28.9%; p < 0.0001). Weight increase was associated with AIDS: OR 3.05 (95%; CI 1.009–9.22), p = 0.048; and lower baseline weight: OR 1.032 (95% CI 1.009–1.05), p = 0.006. Conclusions After ART initiation patients gain weight regardless of the regimen they take. Weight gain is associated with AIDS and the use of TAF/FTC/EVG/c.
Outbreaks of COVID-19 in indoor places of worship: a systematic review
Authors: Bert F , Lo Moro G , Peano A , Previti C , Siliquini R 
Published: September 2022

Aims: This review aimed to describe what has been published on COVID-19 outbreaks originating from indoor places of worship. Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist by searching PubMed, Scopus and Embase from 1 January 2020 to 29 March 2021. Citation chasing was also performed. Studies with information about COVID-19 outbreaks originating in indoor places of worship of any religion were included. Results: A total of 9729 records were identified and 36 were selected. The articles reported 119 descriptions of outbreaks linked to churches, mosques, synagogues, and temples, referring to approximately 52–74 unique outbreaks. The outbreaks were mostly located in three major areas: East and Southeast Asia (46%), the USA (27%), Europe (22%). All the outbreaks began in 2020. Mainly, there were no restrictive measures, or such measures were not followed at the time of the outbreak. Choir practices presented the highest attack rate (up to 0.867). Conclusions: The lack of preventive measures and the role of singing practices were highlighted. Reports were often lacking contact tracing and sometimes did not report the date of outbreak extinction. Moreover, reports came from few geographical areas. Thus, the impact of transmission in places of worship may be largely underestimated.
Fingolimod versus interferon beta 1-a: Benefit–harm assessment approach based on TRANSFORMS individual patient data
Authors: Spanu Alessandra , Aschmann Hélène E , Kesselring Jürg , Puhan Milo A 
Published: September 2022

Background Fingolimod is a disease-modifying drug approved for multiple sclerosis but its benefit–harm balance has never been assessed compared to other active treatments. Objectives Our aim was to compare the benefits and harms of fingolimod with interferon beta-1a using individual patient data from TRial Assessing injectable interferon versus FTY720 Oral in RRMS trial. Methods We modelled the health status of patients over time including Expanded Disability Status Scale measurements, relapses and any adverse events. We assessed the mean health status between arms and the proportion of patients whose health deteriorated or improved relatively to baseline, using a prespecified minimal important difference of 4.6. We performed sensitivity analyses to test our assumptions. Results Main and sensitivity analyses favoured fingolimod 0.5 mg over interferon beta-1a. The average health status difference was 1.01 (95% CI 0.93–1.08). Patients on fingolimod 0.5 mg were 0.47 (95% CI: 0.35–0.63, p < 0.001) times less likely to experience a relevant decline in health status compared to interferon beta-1a patients, with a number needed to treat of 7.10 [5.18, 11.23]. Conclusions Fingolimod's net benefit over interferon beta-1a did not reach the clinical relevance over 1 year, but the decreased risk for health status deterioration may be more pronounced more long term and patients may prefer less treatment burden associated with fingolimod. [Formula: see text]
Evaluation of ASEAN–India Free Trade Regime: A General Equilibrium Approach
Authors: Srivastava Archana , Mathur Rachna , Mathur Somesh K. 
Published: September 2022

The study uses ex-ante simulations of the general equilibrium model to analyze deeper integration and forward looking liberalization measures undertaken by the ASEAN and India to assess the Indo-ASEAN trade in its present dispensation and its futuristic goals. In the first scenario, complete trade liberalisation takes place including both tariff and non-tariff barriers among the ASEAN countries itself. Although the tariffs are quite low among the ASEAN countries, yet there is need to go for complete tariff and non-tariff liberalisation as it constitutes an important part of the trade barriers. The deeper integration measures across ASEAN and India include not only tariff and non-tariff liberalisation but also movement of capital, introduction to output-oriented technologies in sectors like transport and communication, light manufacturing and meat, and meat products with input oriented technological progress in land and natural resources. We use the GTAP-10 to analyse the same and the results reveal huge gains for India and ASEAN nations in the deeper integration simulation scenario. If ASEAN nations liberalize unilaterally on its own as a standalone liberalization, then there would be negative welfare returns for India while it would turn positive for India in case of deeper integration.JEL Classification: F13, F15
Exploring healthcare provider and patient perspectives on current outpatient care of venous leg ulcers and potential interventions to improve their treatment: a mixed methods study in the ulcus cruris care project
Authors: Poß-Doering Regina , Anders Carolin , Fleischhauer Thomas , Szecsenyi Joachim , Senft Jonas.D. 
Published: September 2022

Abstract
Background
The project "Ulcus Cruris Care" aims to improve primary care for patients with venous leg ulcer (VLU) in General Practitioner (GP) practices using a complex intervention comprised of educational components, standardized treatment recommendations, computer-assisted documentation, and case management by non-physician medical assistants (MAs). Prior to implementing and testing the intervention components in general practices, in-depth exploration of current outpatient treatment of VLU patients and relevant implementation determinants was pursued.

Methods
A mixed-methods study explored views of GPs, MAs, and patients regarding current VLU outpatient care and the planned intervention components to identify potential implementation determinants. Data were collected through semi-structured guide-based telephone interviews (n = 29) and a survey questionnaire (n = 28). Interviews were transcribed verbatim. Analysis was inductive initially and finalized in a deductive-inductive approach based on domains of the Theoretical Domains Framework to support structuring of relevant implementation determinants. Survey data were analyzed descriptively.

Results
Current VLU outpatient care was described as frequently tailored to individual wounds and gradient. In general, workload was shared by GPs (diagnostics, counselling) and MAs (wound care). All care providers were aware of compression therapy, yet not all of them considered it essential for VLU care. Standardized operating procedures and educational components including e-learning were considered supportive. Stronger involvement of non-physician assistants was seen as opportunity to optimize VLU care. Concerns were identified regarding integration of software-supported case management into daily practice routines and regarding potential limitations in decision-making autonomy when using standard operating procedures.

Conclusions
Findings in this study emphasize a need for educational interventions addressing VLU care providers as well as patients, particularly with regards to compression therapy. The conception of the planned intervention appears to be adequate and a structured guideline-based case management might be a promising approach for optimization of VLU treatment.
Gastrointestinal microbiota profile and clinical correlations in advanced EGFR-WT and EGFR-mutant non-small cell lung cancer
Authors: Saifon Woraseth , Sensorn Insee , Trachu Narumol , Oranratnachai Songporn , Charoenyingwattana Angkana , Runcharoen Chakkaphan , Monnamo Nanamon , Sukkasem Warawut , Inchareon Pimpin , Suwatanapongched Thitiporn , Chansriwong Phichai , Ativitavas Touch , Panvichian Ravat , Chantratita Wasun , Reungwetwattana Thanyanan 
Published: September 2022

Abstract
Introduction
Difference in clinical responses to cancer therapy in each patient is from several factors. Gastrointestinal microbiota is one of the reasons. However, this correlation remains unknown. This study aims to explore correlation between gastrointestinal microbiota profile and clinical outcomes in Thai advanced non-small cell lung cancer (NSCLC) according to epidermal growth factor receptor (EGFR) status.

Methods
We enrolled 13 patients with advanced EGFR–wild-type (WT) NSCLC who received chemotherapy and 15 patients with EGFR-mutant NSCLC who received EGFR tyrosine kinase inhibitors. We collected fecal samples at baseline and first disease evaluation and performed 16S rRNA gene sequencing by NGS to assess microbiota profile. The correlations between gastrointestinal microbiota and clinical variables were studied.

Results
The clinical characteristics were balanced between the cohorts, excluding significantly higher albumin levels in the EGFR-mutant group. Albumin was the only significant clinical factor affecting the treatment response in multivariate analysis (ORR 15.6%, P = 0.03). Proteobacteria counts were higher in the EGFR-WT group, whereas Bacteroidetes and Firmicutes counts were higher in the EGFR-mutant group. The alpha diversity of the gastrointestinal microbiome was significantly higher in the EGFR-mutant group (Shannon index: 3.82 vs. 3.25, P = 0.022). Following treatment, Proteobacteria counts were lower and Bacteroidetes and Firmicutes counts were higher in both cohorts; the changes were more prominent in the EGFR-WT cohort. No significant correlation between microbiota profile and treatment response were demonstrated in our study. However, beta diversity was significantly different according to severity of adverse events. Enrichment of Clostridia and Bacteroidia was associated with higher adverse event risk in the EGFR-WT cohort.

Conclusions
Proteobacteria was dominant in Thai lung cancer patients both EGFR-WT and EGFR-mutant, and this phylum maybe associate with lung cancer carcinogenesis. Chemotherapy altered the gastrointestinal microbiota, whereas EGFR-TKIs had less effects. Our findings highlight the potential predictive utility of the gastrointestinal microbiota for lung cancer carcinogenesis. Studies with larger cohorts and comparison with the healthy Thai population are ongoing to validate this pilot study.