bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rhodamine‐thiourea Linked Naphthalimide Derivative to Image ATP in Mitochondria using Two Channels
Authors: Rim Lee You , Kwon Nahyun , Swamy K. M. K. , Kim Gyoungmi , Yoon Juyoung 
Published: June 2022

AbstractAdenosine 5′‐triphosphate (ATP), synthesized in mitochondria, is an energy molecule in all living things. ATP not only serves as an energy source for protein synthesis and muscle contraction, but also as an important indicator for various diseases, such as Parkinson's disease, cardiovascular disease, and others. Accordingly, detection and sensing of ATP, especially in mitochondria, are important. In this study, a unique ring‐opening process of rhodamine was coupled to recognition of ATP via introduction of a thiourea moiety, which was further linked to a naphthalimide group. A strong fluorescent emission at ∼580 nm was accompanied by a color change from colorless to pink upon addition of ATP at pH 7.4. Fluorescent probe 1 successfully imaged mitochondrial ATP with a Pearson's coefficient of 0.8. In addition, green emission from the naphthalimide moiety at ∼530 nm was observed without any change upon addition of ATP. This emission can be considered equivalent to an internal standard to utilize probe 1 as a dual‐channel probe for ATP. Furthermore, probe 1 showed negligible cytotoxicity based on MTT assays.
An analysis of China's biomass briquette fuel large‐scale steam heating system
Authors: Zhang Runkai , Wang Yapeng , Sun Yufeng , Wang Zhanwu , Gao Jing , Guo HaiQin , Cheng Shangshang , Xu Guanghui , Li Baoqian , Xu Guangyin 
Published: June 2022

AbstractThe current study took Henan Wufeng New Energy Science Technology Co. Ltd as an example to investigate a large‐scale steam heating system with biomass briquette fuel in Henan, China. Drawn on several months of field research, the economic cost and greenhouse gas emissions for peanut shell straw collection, transportation, storage and burning at Henan Wufeng New Energy Science Technology Co. Ltd were analyzed in 2021. Moreover, the economic cost and greenhouse gas emissions were used as evaluation indicators to evaluate the biomass molding fuel supply system systemically. Economic analysis shows that the steam heating system can make a profit of 1.72 × 106 yuan per year, and the input–output ratio (ROI) is 93.87%, which is much higher than the benchmark input–output ratio (30%). The very high ROI indicates that the system is difficult to operate in an economically feasible manner. Greenhouse gas emission analysis demonstrates that at the same heating level, the system can save 4.42 × 107 kg of standard coal and reduce the emissions of greenhouse gases to the environment by 1.25 × 105 tCO2eq, which has significant environmental benefits. Taken together, the government should adopt effective economic policies to promote the efficient use of biomass straw and support biomass straw recycling and heating enterprises. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd.
A facile turn‐on chemiluminescence probe for sensitive imaging on aminopeptidase N activity
Authors: Sun Ru , Wu Xuesong , Mao Yanjia , Wang Hongbo , Bian Chong , Lv Panpan , Zhao Zhen , Li Xinwei , Fu Wei , Lu Jianzhong , Cao Zhijuan 
Published: June 2022

AbstractAminopeptidase N, as a target for drug discovery, shows marked relationships with many diseases, especially liver injury and cancer. Here, we explored a chemiluminescence (CL) probe for sensing APN by tethering the APN‐specific substrate group to the ortho‐acrylated phenoxy‐dioxetane scaffold. In this way, two CL probes (APN‐CL and BAPN‐CL) were designed with noncapped leucine and butoxy‐carbonyl capped leucine as the protecting group to preserve the chemiexcitation energy. The uncovered leucine was demonstrated to be essential for detection of APN activity by comparing the CL intensity of two CL probes. Probe APN‐CL was turned on upon APN cleavage, resulting in a high chemiluminescent emission, whereas the chemiexcitation energy of probe BAPN‐CL was still restrained even with the high‐level APN. The result was further elucidated by molecular docking simulations. Probe APN‐CL exhibited a fast response and high sensitivity with a detection limit of 0.068 U/L, and an excellent specificity for the discrimination of APN from biological ions, small molecules, and other proteases commonly found in living system. By virtue of good stability and cell viability, probe APN‐CL imaged abnormal levels of APN in tumour cells and tumour‐bearing mice. Moreover, this probe APN‐CL could be easily used to evaluate APN inhibitors and APN levels in plasma samples from 20 patients. Overall, as a facile and cost‐effective probe, APN‐CL will be a promising alternative in the early diagnosis of pathologies and for cost‐effective screening of inhibitors.
Stakeholder theory and actor‐network theory: The stakeholder engagement in energy transitions
Authors: Marcon Nora Gabriela Almeida , Alberton Anete , Ayala Diego Hernando Florez 
Published: June 2022

AbstractThe idea of sustainable development highlights the need to address economic, social, and environmental aspects to preserve the rights and needs of future generations. This paper proposes an association between stakeholder theory (ST) and Actor‐Network Theory (ANT) that can better explain the dynamics of actors in the energy sector, in the context of sociotechnical transitions to sustainability. By selectively examining the way in which different researchers perceive this subject, we intend to address how the engagement of the stakeholders can promote sociotechnical transitions in the energy sector trough the connection between ST and ANT. We aim to characterize the dynamics of stakeholder's engagement in sociotechnical transitions in the context of sustainability in the energy sector, trough the connection of the two theories. A narrative literature review was performed on scientific databases. The results showed that sociotechnical transitions in the energy sector require the involvement of multiple actors with different interests and that ST associated with ANT provides a good basis for research on this theme. The association of both theories highlights the importance of ST to enhance cooperation in the areas of clean energy research and technology, providing a theoretical tool for understanding the dynamics of transitions and its different pathways. For future studies, it is recommended to deepen the relationship between human and non‐human actors and their role as stakeholders.
Orbital inflammatory disease following mRNA SARS‐CoV‐2 vaccine
Authors: Grunenwald Solange , Lethellier Gabriel , Imbert Philippe , Dekeister Céline , Caron Philippe 
Published: June 2022

AbstractA 65‐year‐old woman reported orbital symptoms two days after her first dose and presented exacerbation of signs after the second dose of BNT162b2 mRNA vaccine. The temporal relationship between the COVID‐19 vaccination and orbital symptoms suggests a probable link between SARS‐CoV‐2 mRNA vaccine and this orbital inflammatory disease.
Effects of the Chalcogenide Identity in N‐Aryl Phenochalcogenazine Photoredox Catalysts
Authors: Corbin Daniel A. , Cremer Christopher , Puffer Katherine O. , Newell Brian S. , Patureau Frederic W. , Miyake Garret M. 
Published: June 2022

AbstractPhenochalcogenazines such as phenoxazines and phenothiazines have been widely employed as photoredox catalysts (PCs) in small molecule and polymer synthesis. However, the effect of the chalcogenide in these catalysts has not been fully investigated. In this work, a series of four phenochalcogenazines is synthesized to understand how the chalcogenide impacts catalyst properties and performance. Increasing the size of the chalcogenide is found to distort the PC structure, ultimately impacting the properties of each PC. For example, larger chalcogenides destabilize the PC radical cation, possibly resulting in catalyst degradation. In addition, PCs with larger chalcogenides experience increased reorganization during electron transfer, leading to slower electron transfer. Ultimately, catalyst performance is evaluated in organocatalyzed atom transfer radical polymerization and a photooxidation reaction for C(sp2)−N coupling. Results from these experiments highlight that a balance of PC properties is most beneficial for catalysis, including a long‐lived excited state, a stable radical cation, and a low reorganization energy.
Synthesis of Laser‐Induced Cobalt Oxide for Non‐Enzymatic Electrochemical Glucose Sensors
Authors: Kang Seung‐Jo , Pak James Jungho 
Published: June 2022

AbstractIn this study, an electrochemical non‐enzymatic glucose sensor based on cobalt oxide was designed through CO2 laser irradiation on a Co‐hydrogel formed by spin‐coating a mixture of CoCl2 and gelatin on a polyimide (PI) film. The PI film, which absorbed IR energy through laser irradiation, was grown into laser‐induced graphene fiber (LIGF) with high electrical conductivity and a large surface area. The Co‐hydrogel absorbed the laser‘s IR energy and grew into laser‐induced Co3O4 nano particles (LICONPs) without high temperature annealing for several hours. Because the Co‐hydrogel and the PI film were simultaneously irradiated with laser, LICONPs were attached to the surface of the LIGF, so it had an active surface area 10.5 times larger than the geometric area. The fabricated LICONPs/LIGF was then utilized as a non‐enzymatic glucose sensor working electrode, resulting in high sensitivity of 187,129 μA mM−1 cm−2 in the range of 1–30 μm and low limit of detection (LOD) of 0.10 μm. In addition, LICONPs/LIGF also showed stable reproducibility, repeatability and long‐term stability when used as a part of working electrode of a non‐enzymatic glucose sensor.
Finding reliable methodology for optical rotation and correct predictions of (s)‐methyloxirane and (1R,5R)‐β‐pinene
Authors: de Albuquerque Barros Gabriel , Henrique Morgon Nelson 
Published: June 2022

AbstractTheoretical calculations of optical rotation (OR), although important to predict absolute configurations (ACs) and corroborate experiments, require efficient methodology able to reproduce enantiomer specificity and real OR values. Also, troublesome molecules are recurring in the literature, such as (S)‐methyloxirane and (1R,5R)‐β‐pinene. This study evaluates DFT functionals B3LYP, CAM‐B3LYP, ωB97X‐D, M06‐2X, and PBE0 considering basis sets aug‐cc‐pVDZ, aug‐cc‐pVTZ, 6‐311++G(2d,p), and 6‐311++G(3df,2p) in OR prediction of 42 rigid organic molecules assessing cases with wrong enantiomeric determination comparing to available experimental data at wavelengths 355, 589, and 633 nm. Functionals CAM‐B3LYP and ωB97X‐D with aug‐cc‐pVTZ are indicated here to reproduce experimental values more accurately considering fewer number of wrong AC predictions, normalized RMSD values below 0.70, and a good approximation to experimental values in hierarchical cluster analysis. Methyloxirane AC was reproduced in CAM‐B3LYP and PBE0, with
for CAM‐B3LYP/aug‐cc‐pVTZ close to experimental value
. Good results were found for AC of β‐pinene in M06‐2X, CAM‐B3LYP, and ωB97X‐D while the latter in 6‐311++G(3df,2p) obtained OR values of
and
close to experimental values
and
. The two molecules aforementioned are, for the first time, reported to give valid theoretical OR values in such simple methodologies. OR calculations were all performed after geometry optimization at the same level of theory, and analysis of different functional combinations for each step in β‐pinene showed it can interfere with AC prediction even in rigid molecules.
Dimeric G‐quadruplex DNA Structure in the Proximal Promoter of VEGFR‐2 Reveals a New Drug Target to Inhibit Tumor Angiogenesis
Authors: Zhang Yipeng , Lan Wenxian , Wang Chunxi , Xue Hongjuan , Cao Chunyang 
Published: June 2022

Comprehensive SummaryVascular endothelial growth factor (VEGF) regulates tumor angiogenesis, which is active on the endothelium via VEGF receptor 2 (VEGFR‐2). The proximal promoter region of VEGFR‐2 (termed as VEGFR‐2 DNA) is guanine‐rich, forming G‐quadruplex (G4) structures. Here, we demonstrate that VEGFR‐2 DNA consists of one symmetrically dimeric 14‐mer G4‐DNA and one 12‐mer sequence‐palindromic dsDNA. This G4‐DNA adopts an unprecedented folding with five stacked tetrads linked by four broken strands. Its 5’‐end part contains an A‐tetrad A1•A4•A1’•A4’ and one G‐tetrad G3•G5•G3’•G5’ with two V‐shaped loops and two one‐nt edge‐type loops. Its 3’‐end part includes three G‐tetrads G10•G6•G10’•G6’, G11•G7•G11’•G7’ (central) and G12•G8•G12’•G8’ spanned by two double‐chain‐reversal one‐nt (C9 or C9’) loops. Bases G13 and G13’ stack with G‐tetrad G12•G8•G12’•G8’. These characteristics make this G4‐DNA more stable than reported VEGFR‐17T G4 structure. The dsDNA connects with G4‐DNA without any interactions, generating a linear assembly with G4‐DNA structural bulges. These studies uncover new structural features of VEGFR‐2 DNA as a potential drug target by inhibiting VEGFR‐2 expression, thereby tumor angiogenesis.
CSRbest practices for global multi‐tier sustainable supply chain integration ofChinese MNEs
Authors: Scuotto Veronica , Chin Tachia , Pezzi Alberto , Pironti Marco 
Published: June 2022

AbstractThe interest in global multi‐tier sustainable supply chains is growing proportionally to its increase in developing countries. Developing countries are considered the new fertile territory for developing global chains for multinational enterprises (MNEs). Despite the positive outcomes derived from this global development, it also induces negative impacts in the domain of domestic firms' competition, education, welfare and infrastructure system. A way to overcome this pessimistic view has been found in corporate social responsibility (CSR) best practices. MNEs seek to involve local stakeholders in their social activities to show their commitment and generate innovations. It calls for a multi‐tier domestic involvement integrated into a global supply chain to create value. This study builds its empirical analysis exploring a range of 1547 Chinese manufacturing multinational enterprises listed in the Shanghai and Shenzhen stock exchanges between 2010 and 2018. The findings revealed that multi‐tier supply chain integration (SCI) practices positively moderate the relationship between CSR and MNE performance. In turn, it implies benefits for developing sustainable development goals, generating new job opportunities mostly in the developing countries guaranteeing wealth employment conditions. The sense of involvement and engagement towards their employees requires more development of CSR practices, which can be moderated by multi‐tier SCI, as shown in the present study.
High‐accuracy mean circuits design by manipulating correlation for stochastic computing
Authors: Wang Shaowei , Xie Guangjun , Xu Wenbing , Cheng Xin , Zhang Yongqiang 
Published: June 2022

AbstractStochastic computing (SC) encodes numerical values into probabilistic binary bitstreams to enable complex arithmetic operations to be transformed into simple bit operations. Different operations can be performed through the same SC element by adjusting the correlation between bitstreams. In this work, two stochastic mean circuits (MCs) are proposed by manipulating positively and negatively correlated bitstreams, respectively named PCMC and NCMC, to improve computing accuracy, lower area, and power consumption. Furthermore, a general structure for MCs, denoted as GMC, is also proposed to generalize their design approach. Compared with the existing multiplexer (MUX)‐based stochastic MCs, the proposed circuits have approximately 50%, 59%, 61%, and 64% reduction in area, and 100×, 10×, 151×, and 12 × improvement in MSE, for 2‐, 3‐, 4‐, and 5‐input situations, respectively. With applications to edge detection and mean filtering, the proposed designs are superior to the existing counterparts in terms of accuracy and hardware cost.
Dual‐band dual‐sense broadband circularly polarized parasitic ring loaded monopole antenna for satellite applications
Authors: Bag Biplab , Mondal Kalyan , Sarkar Partha Pratim 
Published: June 2022

SummaryA novel‐shaped dual‐band circularly polarized (CP) monopole antenna is proposed. Two parasitic strips are fabricated under the unique shaped monopole element to get dual broad operation bands. The proposed antenna is fabricated on the FR4 substrate with the specification of the substrate dimension 40 mm × 30 mm,
,
, and loss tangent
. The parasitic elements are responsible to improve the current distribution
and
on the surface. Two CP modes are developed for orthogonally distributions of
and
fields with same magnitude. All the successive CP modes are merged, and a broad AR BW is achieved. The RHCP and LHCP waves radiate along the broadside direction at the lower and higher frequency bands. The achieved two impedance bandwidth and axial ratio (AR) bandwidth are 1.5 GHz (7.05–8.55 GHz), 4.45 GHz (11.65–16.1 GHz) and 1.4 GHz (7.1–8.5 GHz), 0.2 GHz (14.6–14.8 GHz). A very good gain response along with two peak gains of 5.5 dBi and 5.9 dBi is achieved. The proposed antenna is applicable for International Telecommunication Union (ITU) satellite communication (7.25–7.75 GHz, 7.9–8.4 GHz) and Ku‐band satellite applications (11.7–12.2 GHz) and (14–14.5 GHz).
Weight‐bearing physical activity in people with diabetes‐related foot disease: A systematic review
Authors: van Netten Jaap J. , Fijen Vera M. , Bus Sicco A. 
Published: June 2022

AbstractIntroductionWeight‐bearing physical activity is important for people with diabetes‐related foot disease but may also contribute to ulceration or delayed ulcer healing. No overview of weight‐bearing activity of people at different stages of foot disease is available. We aimed to summarise quantitatively measured daily activity levels in people with diabetes‐related foot disease.MethodsWe systematically searched peer‐reviewed literature for studies reporting objectively measured weight‐bearing activity in people with diabetes‐related foot disease. We calculated daily step counts' means (over studies) and weighted means (over participants). International Working Group on the Diabetic Foot (IWGDF) risk strata, different climates, and activity indoors versus outdoors were compared.ResultsFrom 1247 publications, 27 were included. Mean steps/day in people with IWGDF risk 1/2: 6125 (12 studies; 345 participants; weighted mean: 5384). In IWGDF risk 3: 6167 (8 studies; 291 participants; weighted mean: 6239). In those with a foot ulcer: 4248 (6 studies; 186 participants; weighted mean: 4484). People living in temperate oceanic climates are more active compared to those in hotter or more humid climates (mean steps/day for no ulcer: 7712 vs. 5224 [18 studies]; for ulcer: 6819 vs. 2945 [6 studies]). People are more active indoors than outdoors (mean 4047 vs. 2514 [3 studies]).ConclusionLevels of weight‐bearing physical activity are similar between people with diabetes at various risk levels for foot ulceration but lower for those with a foot ulcer. Weight‐bearing activity differs depending on the climatological environment and is higher indoors than outdoors. These findings provide reference for intervention studies or for clinicians aiming to provide mobility advice in this population.
An explanation for negligible senescence in animals
Authors: Xia Canwei , Møller Anders Pape 
Published: June 2022

AbstractNegligible or negative senescence occurs when mortality risk is stable or decreases with age, and has been observed in some wild animals. Age‐independent mortality in animals may lead to an abnormally long maximum individual lifespans and be incompatible with evolutionary theories of senescence. The reason why there is no evidence of senescence in these animals has not been fully understood. Recovery rates are usually very low for wild animals with high dispersal ability and/or small body size (e.g., bats, rodents, and most birds). The only information concerning senescence for most of these species is the reported lifespan when individuals are last seen or caught. We deduced the probability density function of the reported lifespan based on the assumption that the real lifespan corresponding to Weibull or Gompertz distribution. We show that the magnitude of the increase in mortality risk is largely underestimated based on the reported lifespans with low recovery probability. The risk of mortality can aberrantly appear to have a negative correlation with age when it actually increases with increasing lifespan. We demonstrated that the underestimated aging rate for wild animals with low recovery probability can be generalizable to any aging models. Our work provides an explanation for the appearance of negligible senescence in many wild animals. Humans attempt to obtain insights from other creatures to better understand our own biology and its gain insight into how to enhance and extended human health. Our advice is to take a second glance before admiring the negligible senescence in other animals. This ability to escape from senescence is possibly only as beautiful illusion in animals.
Row crop fields provide mid‐summer forage for honey bees
Authors: Silliman Mary R. , Schürch Roger , Malone Sean , Taylor Sally V. , Couvillon Margaret J. 
Published: June 2022

AbstractHoney bees provide invaluable economic and ecological services while simultaneously facing stressors that may compromise their health. For example, agricultural landscapes, such as a row crop system, are necessary for our food production, but they may cause poor nutrition in bees from a lack of available nectar and pollen. Here, we investigated the foraging dynamics of honey bees in a row crop environment. We decoded, mapped, and analyzed 3459 waggle dances, which communicate the location of where bees collected food, for two full foraging seasons (April–October, 2018–2019). We found that bees recruited nestmates mostly locally (<2 km) throughout the season. The shortest communicated median distances (0.474 and 0.310 km), indicating abundant food availability, occurred in July in both years, which was when our row crops were in full bloom. We determined, by plotting and analyzing the communicated locations, that almost half of the mid‐summer recruitment was to row crops, with 37% (2018) and 50% (2019) of honey bee dances indicating these fields. Peanut was the most attractive in July, followed by corn and cotton but not soybean. Overall, row crop fields are indicated by a surprisingly large proportion of recruitment dances, suggesting that similar agricultural landscapes may also provide mid‐summer foraging opportunities for honey bees.