bluuebunny/crossref_metadata_2025_split huggingface dataset:
MPK6‐mediated HY5 phosphorylation regulates light‐induced anthocyanin accumulation in apple fruit
Authors: Xing Yifan , Sun Wenjing , Sun Yuying , Li Jialin , Zhang Jie , Wu Ting , Song Tingting , Yao Yuncong , Tian Ji 
Published: October 2022

SummaryLight is known to regulate anthocyanin pigment biosynthesis in plants on several levels, but the significance of protein phosphorylation in light‐induced anthocyanin accumulation needs further investigation. In this study, we investigated the dynamics of the apple fruit phosphoproteome in response to light, using high‐performance liquid chromatography–tandem mass spectrometry analysis. Among the differentially phosphorylated proteins, the bZIP (basic leucine zipper) transcription factor, HY5, which has been identified as an anthocyanin regulator, was rapidly activated by light treatment of the fruit. We hypothesized that phosphorylated MdHY5 may play a role in light‐induced anthocyanin accumulation of apple fruit. Protein interaction and phosphorylation assays showed that mitogen‐activated protein kinase MdMPK6 directly interacted with, and activated, MdHY5 via phosphorylation under light conditions, thereby increasing its stability. Consistent with this finding, the suppression of the mitogen‐activated protein kinase genes MdMPK6 or MdHY5 resulted in an inhibition of anthocyanin accumulation, and further showed that light‐induced anthocyanin accumulation is dependent on MdMPK6 kinase activity, and is required for maximum MdHY5 activity. Under light conditions, active MdMPK6 phosphorylated MdHY5 leading to accumulation of phospho‐MdHY5, which enhanced the binding of MdHY5 to its target anthocyanin related genes in fruit. Our findings reveal an MdMPK6–MdHY5 phosphorylation pathway in light‐induced anthocyanin accumulation, providing new insights into the regulation of light‐induced anthocyanin biosynthesis in apple fruit at both the transcriptional and post‐translational levels.
Molecular mechanisms and genetic improvement of low‐phosphorus tolerance in rice
Authors: Lu Hong , Wang Fei , Wang Yan , Lin Rongbin , Wang Zhiye , Mao Chuanzao 
Published: October 2022

AbstractPhosphorus (P) is a macronutrient required for plant growth and reproduction. Orthophosphate (Pi), the preferred P form for plant uptake, is easily fixed in the soil, making it unavailable to plants. Limited phosphate rock resources, low phosphate fertilizer use efficiency and high demands for green agriculture production make it important to clarify the molecular mechanisms underlying plant responses to P deficiency and to improve plant phosphate efficiency in crops. Over the past 20 years, tremendous progress has been made in understanding the regulatory mechanisms of the plant P starvation response. Here, we systematically review current research on the mechanisms of Pi acquisition, transport and distribution from the rhizosphere to the shoot; Pi redistribution and reuse during reproductive growth; and the molecular mechanisms of arbuscular mycorrhizal symbiosis in rice (Oryza sativa L.) under Pi deficiency. Furthermore, we discuss several strategies for boosting P utilization efficiency and yield in rice.
Hematopoietic stem cell transplantation activities and HRQOL of refugee or asylum seeker children in Turkey: A multicenter study
Authors: Gurlek Gokcebay Dilek , Küpeli Serhan , Gürsel Orhan , Arman Bilir Ozlem , Akyay Arzu , Pekpak Esra , Akbayram Sinan , Öncül Yurday , Meral Güneş Adalet , Kirkiz Serap , Çakı Kılıç Suar , Ok Bozkaya İkbal , Ozbek Namık Yasar 
Published: October 2022

AbstractBackgroundRefugee or asylum seekers (RAS) children are at increased risk of physical, developmental, and behavioral health issues. The aim of this study was to evaluate clinical and psychosocial outcomes of hematopoietic stem cell transplantation (HSCT) in RAS children and compare health‐related quality of life (HRQOL) to those of Turkish peers.MethodsThis retrospective study included patients who underwent HSCT aged 0–18 years and completed 100‐day post‐transplant. The PedsQL 4.0 Generic Core Scale was used in children over 5 years old to compare HRQOL.ResultsA total of 166 RAS patients (M/F: 106 /60) underwent 174 HSCTs (six patients had two, and one had three HSCT) compared to 66 Turkish patients. The mean age of the patients in the RAS group was 7.8 ± 4.9 years and similar to controls. A total of 124 patients (75%) were from Syria, and 49 (25%) were from other countries in the Middle East and Africa. The cause of migration was war in 121 (74%) RAS patients. Complications of HSCT were no different between the groups. However, the rate of neutropenic sepsis was significantly higher in the RAS group (p = 0.004). The total scores of HRQOL were not different between RAS and controls. In the RAS group, ratings of social functioning were lower in patients with consanguinity or non‐malignant disease or who had match‐related donors.DiscussionIdentifying areas of difficulty in subscales of HRQOL may help physicians to classify patients who need additional supportive care. Regular monitoring and supporting physical needs may result in better functional outcomes after HSCT.
Skin type specific photobiological response to visible light is mediated by constitutional melanin
Authors: Lim Hester Gail , Kerns Michelle L. , Brown Isabelle D. , Kang Sewon , Chien Anna L. 
Published: October 2022

AbstractBackgroundVisible light (VL) induces varying photobiological responses between skin types, likely influenced by inherent melanization. Individual typology angle (ITA) objectively measures skin types. We hypothesize that epidermal melanin content and distribution determine VL response.ObjectivesThis study describes clinical and histologic responses to VL and examines the potential role of melanin in the underlying mechanistic pathways.MethodsWe grouped enrolled participants by ITA (Light = 5, Intermediate = 4, Dark = 7) per colorimetry (CR‐400, Konica Minolta). Photoprotected sites were exposed daily to 480 J/cm2 of VL (Fiber‐Lite High Intensity Illuminator, Series 180, Dolan Jenner Industries Inc.) for 4 days (total = 1920 J/cm2), as tolerated. Treated and control sites were biopsied 96 h after first exposure. We used hematoxylin and eosin and Fontana‐Mason to assess histological changes and melanin deposition, respectively. p53 and Ki67 immunohistochemical stains were done to assess DNA damage and proliferation. Matrix metalloproteinase (MMP)‐1 expression was detected by immunohistochemical staining and immunofluorescence microscopy.ResultsDarker skin did not tolerate the full VL regimen with blistering occurring in most subjects at doses of 220–880 J/cm2. Intermediate and Dark skin showed tanning. Light skin developed erythema. p53 counts were highest in Intermediate, followed by Light skin, although this was not statistically significant. VL treatment led to MMP‐1 expression and nuclear localization in keratinocytes in Dark and Intermediate but not in Light skin, however differences between groups were not statistically significant.ConclusionsSkin types demonstrate unique biological responses to VL. The role of melanin in photoprotection is well‐defined. However, given the pro‐apoptotic function of nuclear MMPs, we suggest a potential mechanism by which melanin may mediate VL‐induced phototoxicity.
Does intrahousehold bargaining power enhance women's marital satisfaction? A perspective from two competing forces in China
Authors: Li Zhongwu 
Published: October 2022

AbstractIn the context of two competing forces (i.e., socioeconomic transformation vs. traditional cultural norms) influencing Chinese family and its members, the paper uses the China Family Panel Studies (CFPS) to empirically examine the causal relation between intrahousehold bargaining power and women's marital satisfaction. By employing an instrumental variable approach, the paper finds that intrahousehold bargaining power negatively affects women's marital satisfaction. This conclusion remains valid after performing various robustness checks. However, there are some heterogeneous effects found that the negative effect is particularly significant among those women of higher age and constrained by external traditional norms. These women are more conservative in their own thoughts and thus tend to support the traditional gender belief of “men being the masters of the family.”
Splenectomy outcomes in patients with autoimmune cytopenias and persistent antiphospholipid antibodies
Authors: Rangel‐Patiño Juan , Barrera‐Vargas Ana , Govea‐Pelaéz Samuel , Merayo‐Chalico Javier , Pérez‐Sámano Daniela , Vargas‐Serafín Omar , Demichelis‐Gómez Roberta 
Published: October 2022

AbstractBackgroundSplenectomy is a therapy for patients with treatment‐refractory autoimmune cytopenias. Antiphospholipid antibodies (aPL) can be identified in 25%–85% of these patients. In this study, we sought to identify whether the presence of aPL was associated with worse outcomes in autoimmune cytopenia's patients who had undergone splenectomy.MethodsWe conducted a retrospective cohort study of patients who underwent splenectomy from 2000 to 2018. We describe clinical characteristics and outcomes in patients with autoimmune cytopenia's diagnosis with positive determinations of aPL. Additionally, we performed a case–control sub‐analysis 1:1 of the cases with autoimmune cytopenia's matched control patients with negative aPL determination.ResultsA splenectomy was performed in 707 patients, of which we included 34 for the analysis. The median age at the time of splenectomy was 37 years (range 19–61), 53% corresponded to immune thrombocytopenia (ITP) and 47% to autoimmune hemolytic anemia (AIHA). Compared with controls (n = 34), patients had more treatment lines in addition to steroids (p = .02). There were no differences in complete response rate, 65% in cases and 80% in controls (p = .17). However, there was numerically a higher incidence of early infections (21% of cases vs. 3% controls, p = .05). During the entire follow‐up, 15% of aPL patients compared with 9% of control patients had a thrombotic event (p = .70).DiscussionSplenectomy for treatment‐refractory autoimmune cytopenia's patients with persistent aPL is an effective treatment despite some safety concerns related to early infections. These results suggest that the presence of aPL should not impact the decision to undergo splenectomy.
The effect of the Messinian salinity crisis on the early diversification of the Tettigettalna cicadas
Authors: Costa Gonçalo J. , Nunes Vera L. , Marabuto Eduardo , Mendes Raquel , Silva Diogo N. , Pons Pere , Bas Josep M. , Hertach Thomas , Paulo Octávio S. , Simões Paula C. 
Published: October 2022

AbstractThe current distribution patterns of many Mediterranean species are often a consequence of large and impactful past geoclimatic events, such as the Messinian Salinity Crisis (MSC) and the Quaternary glacial cycles. Cicadas are flying insects with poor dispersal ability, which have experienced intense local differentiation in the Mediterranean, where the genus Tettigettalna has surfaced as a biogeographic model. The genus includes 10 species with species‐specific calling songs but identical morphology. All Tettigettalna species are restricted to Southern Iberia, with the exception of T. estrellae (northwest Iberia), the widespread T. argentata (mainly Iberia, France and Italy), and T. afroamissa (Morocco). With an expanded genetic dataset involving nuclear (EF1α) and mitochondrial (5′ and 3′ COI and ATP) loci, we reconstructed the phylogeny of the genus and estimated divergence dates for Tettigettalna species under a Bayesian framework. Phylogeny with the new mitochondrial dataset was in agreement with previous studies, whereas the nuclear EF1α supported T. josei and T. afroamissa as monophyletic clades but lacked resolution to resolve the remaining taxa. Some sister taxa share mitochondrial haplotypes, hinting for incomplete lineage sorting. Estimates of divergence time settled T. josei as the earliest diverging lineage, likely as a pre‐ or early‐MSC event. As for the origin of T. afroamissa in Morocco, though time estimates could not entirely rule out post‐MSC dispersal, the most likely scenario points to isolation of African Tettigettalna after the reopening of the strait of Gibraltar. The Pleistocene glaciations that followed likely impacted on the diversification of the remaining species of the genus in southern Iberia refugia.
Generation of quantum coherence for continuous variables between causally disconnected regions in dilaton spacetime
Authors: Xiao Qinglong , Wen Cuihong , Jing Jiliang , Wang Jieci 
Published: October 2022

AbstractWe study the dynamics of Gaussian quantum coherence under the background of a Garfinkle–Horowitz–Strominger dilaton black hole. It is shown that the dilaton field has evident effects on the degree of coherence for all the bipartite subsystems. The bipartite Gaussian coherence is not affected by the frequency of the scalar field for an uncharged or an extreme dilaton black hole. It is found that the initial coherence is not completely destroyed even for an extreme dilaton black hole, which is quite different from the behavior of quantum steering because the latter suffers from a “sudden death” under the same conditions. This is nontrivial because one can employ quantum coherence as a resource for quantum information processing tasks even if quantum correlations have been destroyed by the strong gravitational field. In addition, it is demonstrated that the generation of quantum coherence between the initial separable modes is easier for low-frequency scalar fields. At the same time, quantum coherence is smoothly generated betweenone pair of partners and exhibits a “sudden birth” behavior between another pairs in the curved spacetime.
Long term measurement of the $$^{222}$$Rn concentration in the Canfranc Underground Laboratory
Authors: Amaré J. , Bandac I. , Blancas A. , Borjabad S. , Buisán S. , Cebrián S. , Cintas D. , Coarasa I. , García E. , Martínez M. , Núñez-Lagos R. , Oliván M. A. , Ortigoza Y. , de Solórzano A. Ortiz , Pérez C. , Puimedón J. , Rodríguez S. , Salinas A. , Sarsa M. L. , Villar P. 
Published: October 2022

AbstractWe report the results of 6 years (2013–2018) of measurements of $$^{222}$$

222

Rn air concentration, relative humidity, atmospheric pressure and temperature in the halls A, B and C of the Canfranc Underground Laboratory (LSC). We have calculated all the Pearson correlation coefficients among these parameters and we have found a positive correlation between the $$^{222}$$

222

Rn concentration and the relative humidity. Both correlated variables show a seasonal periodicity. The joint analysis of laboratory data and 4 years (2015–2018) of the meteorological variables outside the laboratory shows the correlation between the $$^{222}$$

222

Rn concentration and the outside temperature. The collected information stresses the relevance of designing good Rn-mitigation strategies in current and future experiments at LSC; in particular, we have checked for two years (2017–2018) the good performance of the mitigation procedure of the ANAIS-112 experiment. Finally, we have monitored (2019–2021) for 2 years of live time, the radon-free air provided by the radon abatement system installed in the laboratory.
Imprints of anisotropy on the power spectrum in matter dominated bouncing universe as background
Authors: Modan Asha B. , Panda Sukanta , Rana Arun 
Published: October 2022

AbstractIn this paper, we aim to investigate the effects of the anisotropy on the scale-invariant power spectrum considering the matter-dominated collapsing universe as background and look for the deviations from the scale invariance. Having set up this background, we consider a test massless scalar field and work out the correlations for the field, first by using the perturbative approach in which the anisotropic background is approximated with an effective isotropic metric represented by the metric of matter dominated collapsing universe, second by directly solving the field equation numerically, and then obtain the power spectrum for the range of modes which are of cosmological interest. Using both techniques, we get an upper bound on the deviation in the power spectrum from the scale invariance. We also work out the power spectrum for much smaller modes and look at whether it is possible to explain the observed anomalies in CMB via the matter bounce scenario.
The deep space quantum link: prospective fundamental physics experiments using long-baseline quantum optics
Authors: Mohageg Makan , Mazzarella Luca , Anastopoulos Charis , Gallicchio Jason , Hu Bei-Lok , Jennewein Thomas , Johnson Spencer , Lin Shih-Yuin , Ling Alexander , Marquardt Christoph , Meister Matthias , Newell Raymond , Roura Albert , Schleich Wolfgang P. , Schubert Christian , Strekalov Dmitry V. , Vallone Giuseppe , Villoresi Paolo , Wörner Lisa , Yu Nan , Zhai Aileen , Kwiat Paul 
Published: October 2022

AbstractThe National Aeronautics and Space Administration’s Deep Space Quantum Link mission concept enables a unique set of science experiments by establishing robust quantum optical links across extremely long baselines. Potential mission configurations include establishing a quantum link between the Lunar Gateway moon-orbiting space station and nodes on or near the Earth. This publication summarizes the principal experimental goals of the Deep Space Quantum Link. These goals, identified through a multi-year design study conducted by the authors, include long-range teleportation, tests of gravitational coupling to quantum states, and advanced tests of quantum nonlocality.
Initial Characterization of Focal Bone Lesions with Conventional Radiographs or Computed Tomography: Diagnostic Performance and Interobserver Agreement Assessment
Authors: Gondim Teixeira Pedro Augusto , Lombard Charles , Moustache-Espinola Patrice , Germain Edouard , Gillet Romain , Hossu Gabriela , Jaquet Ribeiro Guilherme , Blum Alain 
Published: October 2022

Objectives: To ascertain the role of CT and conventional radiographs for the initial characterization of focal bone lesions. Methods: Images from 184 patients with confirmed bone tumors included in an ethics committee-approved study were retrospectively evaluated. The reference for benign-malignant distribution was based on histological analysis and long-term follow-up. Radiographs and CT features were analyzed by 2 independent musculoskeletal radiologists blinded to the final diagnosis. Lesion margins, periosteal reaction, cortical lysis, endosteal scalloping, presence of pathologic fracture, and lesion mineralization were evaluated. Results: The benign-malignant distribution in the study population was 68.5–31.5% (126 benign and 58 malignant). In the lesions that could be seen in both radiographs and CT, the performance of these methods for the benign-malignant differentiation was similar (accuracy varying from 72.8% to 76.5%). The interobserver agreement for the overall evaluation of lesion aggressiveness was considerably increased on CT compared to radiographs (Kappa of .63 vs .22). With conventional radiographs, 18 (9.7%) and 20 (10.8%) of the lesions evaluated were not seen respectively by readers 1 and 2. Among these unseen lesions, 50%–61.1% were located in the axial skeleton. Compared to radiographs, the number of lesions with cortical lysis and endosteal scalloping was 26–34% higher with CT. Conclusion: Although radiographs remain the primary imaging tool for lesions in the peripheral skeleton, CT should be performed for axial lesions. CT imaging can assess the extent of perilesional bone lysis more precisely than radiographs with a better evaluation of lesion fracture risk.
High mobility group box protein 1 (HMGB1) serum and urinary levels and gene polymorphism in Egyptian patients with systemic lupus erythematosus: A possible relation to lupus nephritis
Authors: Hisham Fatma A , Tharwat Samar , Samra Nouran E , Mostafa Nora , Nassar Mohammed K , El-Desoky Manal M. 
Published: October 2022

Objective The aim of this study was to evaluate the effects of the high mobility group box protein 1 (HMGB1) serum and urinary levels and gene polymorphisms on systemic lupus erythematosus (SLE) development and investigate their link to lupus nephritis (LN). Methods We enrolled 120 Egyptian SLE patients and 120 healthy controls. Thorough medical and clinical evaluation were carried out, and SLE disease activity index (SLEDAI) was assessed. Lupus patients were divided into two groups according to the presence of LN. Measurement of HMGB1 serum and urinary levels was done using ELISA and genotyping for HMGB1 ( rs1045411) was performed. Results There were statistically significantly higher HMGB1 serum and urinary levels in SLE patients ( p < 0.001). There was a marginally significant association between lupus and alleles ( p = 0.059, φ = −0.086). ‘C’ allele was marginally significant risk allele for SLE. After classifying SLE patients based on the presence or absence of LN, there was no significant difference as regard sex ( p = 0.387), age ( p = 0.208) and disease duration ( p = 0.094).However, there was a significant difference between the 2 groups in regard to the frequency of musculoskeletal manifestations ( p = 0.035), SLEDAI score ( p < 0.001), both serum ( p < 0.001) and urinary HMGB1 levels ( p < 0.001) in addition to the frequency of HMGB1 genotypes ( p = 0.003). Lupus patients with C/T-T/T HMGB1 genotypes had 3.5-times higher odds to exhibit LN. Conclusions Serum and urine HMGB1 measurements are helpful in the diagnosis of SLE and the prediction of LN. There is a link between HMGB1 gene variations and the risk of SLE, with evidence that the C/T-T/T HMGB1 genotype is linked to a significantly greater risk of LN in the Egyptian population.
Insights into the lanthanum doping large-size graphene oxide effect on the polymer composites
Authors: Li Yasen , Shang Yudong , Wu Yuanyuan , Ren Yan , Zhao Chuan , Zhang Jing , He Jiangping , Li Tiehu 
Published: October 2022

Despite the significant progress made in polymer/graphene nanocomposites, the development of high-performance polymer/graphene nanocomposites, combined with excellent mechanical and electromagnetic shielding properties, remains a priority and a challenge. The lanthanum doping large-size graphene oxide (La-LsG) was obtained via static oxidation and thermal treatment. The effects of static oxidation and lanthanum doping on the property and morphologies of graphene and composites were investigated. The physicochemical property of considerable graphene oxide (GO), large-size graphene oxide (LsGO), lanthanum-doped graphene oxide (La-GO), La-LsG was analyzed by transmission electron microscopy (TEM), scanning electron microscopy (SEM), Raman spectroscopy, and X-ray energy spectroscopy (EDS). SEM and EDS characterized the microstructure of the composite material, and the mechanical properties and electromagnetic shielding performance of the composite material were studied. La-GO and La-LsG exhibited good dispersion and structural integrity, as well as enhancing the strength of the composites. The La-LsG/poly (methyl methacrylate) (PMMA) composites exhibited excellent mechanical properties (is ca. 73.6 MPa) and electromagnetic shielding effectiveness (is ca. 28 dB) in X-band frequencies (8.2–12.4 GHz), which may be assumed to be a promising integrated material of structure and function.