bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-monotonic developmental trend of holistic processing in visual expertise: the case of Chinese character recognition
Authors: Tso Ricky Van-yip , Au Terry Kit-fong , Hsiao Janet Hui-wen 
Published: May 2022

AbstractHolistic processing has been identified as an expertise marker of face and object recognition. By contrast, reduced holistic processing is purportedly an expertise marker in recognising orthographic characters in Chinese. Does holistic processing increase or decrease in expertise development? Is orthographic recognition a domain-specific exception to all other kinds of recognition (e.g. face and objects)? In two studies, we examined the developmental trend of holistic processing in Chinese character recognition in Chinese and non-Chinese children, and its relationship with literacy abilities: Chinese first graders—with emergent Chinese literacy acquired in kindergarten—showed increased holistic processing perhaps as an inchoate expertise marker when compared with kindergartners and non-Chinese first graders; however, the holistic processing effect was reduced in higher-grade Chinese children. These results suggest a non-monotonic inverted U-shape trend of holistic processing in visual expertise development: An increase in holistic processing due to initial reading experience followed by a decrease in holistic processing due to literacy enhancement. This result marks the development of holistic and analytic processing skills, both of which can be essential for mastering visual recognition. This study is the first to investigate the developmental trend of holistic processing in Chinese character recognition using the composite paradigm.
Target-rate effect in continuous visual search
Authors: Chan Louis K. H. , Chan Winnie W. L. 
Published: May 2022

AbstractFrom infrared body temperature surveillance to lifeguarding, real-life visual search is usually continuous and comes with rare targets. Previous research has examined realistic search tasks involving separate slides (such as baggage screening and radiography), but search tasks that require continuous monitoring have generally received less attention. In this study, we investigated whether continuous visual search would display a target-rate effect similar to the low-prevalence effect (LPE) in regular visual search. We designed a continuous detection task for a target feature (e.g., a green color) among items of continuously and gradually changing features (e.g., other colors). In four experiments, we demonstrated target-rate effects in terms of slower hit response times (RTs) and higher miss rates when targets were rare. Similar to regular search, target-rate effects were also observed for relative frequencies across two target features. Taken together, these results suggest a target-rate effect in continuous visual search, and its behavioral characteristics are generally similar to those of the LPE in regular visual search.
Coupled Cluster Downfolding Theory: towards universal many-body algorithms for dimensionality reduction of composite quantum systems in chemistry and materials science
Authors: Bauman Nicholas P. , Kowalski Karol 
Published: May 2022

AbstractThe recently introduced coupled cluster (CC) downfolding techniques for reducing the dimensionality of quantum many-body problems recast the CC formalism in the form of the renormalization procedure allowing, for the construction of effective (or downfolded) Hamiltonians in small-dimensionality sub-space, usually identified with the so-called active space, of the entire Hilbert space. The resulting downfolded Hamiltonians integrate out the external (out-of-active-space) Fermionic degrees of freedom from the internal (in-the-active-space) parameters of the wave function, which can be determined as components of the eigenvectors of the downfolded Hamiltonians in the active space. This paper will discuss the extension of non-Hermitian (associated with standard CC formulations) and Hermitian (associated with the unitary CC approaches) downfolding formulations to composite quantum systems commonly encountered in materials science and chemistry. The non-Hermitian formulation can provide a platform for developing local CC approaches, while the Hermitian one can serve as an ideal foundation for developing various quantum computing applications based on the limited quantum resources. We also discuss the algorithm for extracting the semi-analytical form of the inter-electron interactions in the active spaces.
P2X7 1513A/C loss-of-function polymorphism and active tuberculosis disease in a cohort of Egyptian population: a pilot study
Authors: Shafiek Hanaa , Shabana Ahmed , El-Seedy Ayman , Khalil Yehia 
Published: May 2022

Abstract
Background
Tuberculosis (TB) is a multifactorial disease, and increasing evidence shows that genetic variants in regulating genes of immune response confer susceptibility to active TB at the individual level. We aimed to identify the contribution of P2X7 receptor 1513A/C genetic polymorphisms to different clinical forms of active tuberculosis in a cohort of Egyptian population.

Methods
A case–control study that enrolled 25 newly diagnosed pulmonary TB (PTB) patients by positive sputum for AFB or positive culture, 25 extrapulmonary TB (EPTB) diagnosed by pathological/bacteriological/immunological studies and 25 healthy controls. A blood sample was taken before starting of therapy for P2X7 1513A/C polymorphism genotyping using PCR-restriction fragment length polymorphism.

Results
Fifty-two percent of the participants were in the third decade with equal gender distribution. P2X7 receptor 1513AA (homozygote wild), AC (heterozygote) and CC (homozygote mutant) genotypes were identified. AC and CC genotypes distribution were significantly more frequent in the active TB cases (either PTB or EPTB) rather than controls (p < 0.05). Further, P2X7 1513A/C genotypes’ distribution did not associate with old TB or gender (p > 0.05), but significantly associated with history of smoking (x2 trend analysis p = 0.036).

Conclusions
There is positive association between P2X7 receptor 1513A/C polymorphism and active tuberculosis in the Egyptians.
Eosinophil count: a predictor of in-hospital mortality in a cohort of cirrhosis patients with sepsis
Authors: Anoop K. V. , Devadas Krishnadas , Varghese Jijo 
Published: May 2022

Abstract
Background
Declining eosinophil count has recently been associated with sepsis. Thus, absolute eosinophil count (AEC) can be used as a marker of the severity of sepsis, which helps in the early identification of high-risk patients, and better management can be offered to such patients. The aim of this study was to assess whether AEC at the time of ICU admission can be used as a predictor of in-hospital mortality in cirrhotics with sepsis.

Results
This was a retrospective study which was conducted in 105 cirrhotic patients admitted with sepsis in the Department of Gastroenterology, Medical College Trivandrum, from May 2014 to October 2014. Every consecutive patient with cirrhosis and sepsis (defined as systemic inflammatory response syndrome (SIRS) and the presence of infections) admitted to the ICU/high dependency unit was recruited for the study. Among the various parameters analyzed, model for end-stage liver disease (MELD) score, Child-Pugh Turcot (CTP) score, albumin levels, total count, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), alanine aminotransferase (ALT), bilirubin, creatinine, urea, and absolute eosinophil count were statistically significant in predicting in-hospital mortality. The AUROC of AEC was plotted and found to be 0.881, which was better than other parameters for predicting in-hospital mortality. The cutoff of AEC by Youden’s index was 110 cells/cumm (sensitivity 91.3%, specificity 89%, positive predictive value 87.5%, and negative predictive value 93%) to predict in-hospital mortality. The AUROC of MELD was 0.78 with a cutoff of > 24 (sensitivity 89%, specificity 74.6%, positive predictive value 73%, and negative predictive value 89%) to predict the mortality. The odds ratio for predicting mortality was highest for absolute eosinophil count (92.75) followed by MELD (24.57), total count (20.475), CTP (10), and the presence of SIRS (9.08).

Conclusion
In critically ill cirrhosis patients with sepsis, AEC < 110 cells/cumm can predict in-hospital mortality.
Platypnea-orthodeoxia syndrome in COVID-19: rare, not uncommon
Authors: Kumawat Renu , Lal Mahesh , S. Jagadeesan , Varshney Prarit 
Published: May 2022

AbstractCOVID-19 is a contagious disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). As humanity continues to fight this virus, it keeps presenting with new manifestations and complications. Platypnea-orthodeoxia syndrome (POS) is a rare clinical syndrome characterized by dyspnea and oxygen desaturation, in the supine to sitting position, which resolves with recumbency and can be diagnosed with a simple pulse oximeter. We report three cases of COVID-19 pneumonia, who developed POS during the recovery phase, in the absence of pulmonary hypertension.
Transformation of Ritonavir Nanocrystal Suspensions into a Redispersible Drug Product via Vacuum Drum Drying
Authors: Schönfeld Barbara V. , Westedt Ulrich , Keller Benjamin-Luca , Wagner Karl G. 
Published: May 2022

AbstractThe present study explored vacuum drum drying (VDD) as potential drying technique for the solidification of crystalline ritonavir nanosuspensions prepared by wet-ball milling. In detail, the impact of drying protectants (mannitol, lactose, trehalose) added to the ritonavir nanosuspension was assessed in dependence of the drum temperature with respect to processibility via VDD, resulting intermediate powder properties, remaining nanoparticulate redispersibility and crystallinity. A clear impact of the glass transition temperature (Tg) of the drying protectant on the redispersibility/crystallinity of the VDD intermediate was observed. Increased Tg of the drying protectant was associated with improved redispersibility/crystallinity at a defined drum temperature. Consequently, the high Tg-substance trehalose and lactose showed a better performance than mannitol at higher drum temperatures. However, the processability and related powder properties were not in accordance with this observation. Mannitol containing formulations showed superior processibility to those containing trehalose/lactose. Moreover, the impact of the tableting and encapsulation process on the redispersibility of the VDD intermediate was studied for a selected formulation. Neither process demonstrated a negative impact on redispersibility. In conclusion, vacuum drum drying is a promising drying technique for the solidification of nanosuspensions to result in dried powder still containing ritonavir nanoparticles while demonstrating acceptable to good downstream processibility to tablets/capsules.
Graphical Abstract
Epidural Steroid Injections Acutely Suppress Bone Formation Markers in Postmenopausal Women
Authors: Clare Shannon , Dash Alexander , Liu Yi , Harrison Jonathan , Vlastaris Katelyn , Waldman Seth , Griffin Robert , Cooke Paul , Vad Vijay , Casey Ellen , Bockman Richard S , Lane Joseph , McMahon Donald , Stein Emily M 
Published: May 2022

Abstract

Context
Over 9 million epidural steroid injections (ESIs) are performed annually in the United States. Although these injections effectively treat lumbar radicular pain, they may have adverse consequences, including bone loss.

Objective
To investigate acute changes in bone turnover following ESI. We focused on postmenopausal women, who may be at greatest risk for adverse skeletal consequences due to the combined effects of ESIs with aging and estrogen deficiency.

Methods
Single-center prospective observational study. Postmenopausal women undergoing lumbar ESIs and controls with no steroid exposure were included. Outcomes were serum cortisol, markers of bone formation, osteocalcin, and procollagen type-1 N-terminal propeptide (P1NP), and bone resorption by C-telopeptide (CTX) measured at baseline, 1, 4, 12, 26, and 52 weeks after ESIs.

Results
Among ESI-treated women, serum cortisol declined by ~50% 1 week after injection. Bone formation markers significantly decreased 1 week following ESIs: osteocalcin by 21% and P1NP by 22%. Both markers remained suppressed at 4 and 12 weeks, but returned to baseline levels by 26 weeks. There was no significant change in bone resorption measured by CTX. Among controls, there were no significant changes in cortisol or bone turnover markers.

Conclusion
These results provide evidence of an early and substantial reduction in bone formation markers following ESIs. This effect persisted for over 12 weeks, suggesting that ESIs may have lasting skeletal consequences. Given the large population of older adults who receive ESIs, further investigation into the long-term skeletal sequelae of these injections is warranted.
Streptozotocin-induced Diabetes Represses Hepatic CYP2R1 Expression but Induces Vitamin D 25-Hydroxylation in Male Mice
Authors: Elkhwanky Mahmoud-Sobhy , Kummu Outi , Hakkola Jukka 
Published: May 2022

Abstract
Vitamin D deficiency [ie, low plasma 25-hydroxyvitamin D (25-OH-D)] associates with the prevalence of metabolic diseases including type 1 diabetes; however, the molecular mechanisms are incompletely understood. Recent studies have indicated that both fasting and metabolic diseases suppress the cytochrome P450 (CYP) 2R1, the major hepatic vitamin D 25-hydroxylase. We specifically studied the effect of a mouse model of type 1 diabetes on the regulation of Cyp2r1 and vitamin D status. We show that streptozotocin-induced diabetes in mice suppresses the expression of the Cyp2r1 in the liver. While insulin therapy normalized the blood glucose levels in the diabetic mice, it did not rescue the diabetes-induced suppression of Cyp2r1. Similar regulation of Cyp2r1 was observed also in the kidney. Plasma 25-OH-D level was not decreased and was, in contrast, higher after 4 and 8 weeks of diabetes. Furthermore, the vitamin D 25-hydroxylase activity was increased in the livers of the diabetic mice, suggesting compensation of the Cyp2r1 repression by other vitamin D 25-hydroxylase enzymes. Cyp27b1, the vitamin D 1α-hydroxylase, expression in the kidney and the plasma 1α,25-dihydroxyvitamin D level were higher after 4 weeks of diabetes, while both were normalized after 13 weeks. In summary, these results indicate that in the mouse model of type 1 diabetes suppression of hepatic Cyp2r1 expression does not result in reduced hepatic vitamin D 25-hydroxylase activity and vitamin D deficiency. This may be due to induction of other vitamin D 25-hydroxylase enzymes in response to diabetes.
Gestational Diabetes Sensitizes Mice to Future Metabolic Syndrome That Can Be Relieved by Activating CAR
Authors: Feng Ye , Xu Dan , Cai Xinran , Xu Meishu , Garbacz Wojciech G , Ren Songrong , Jurczak Michael J , Yu Chaohui , Wang Hui , Xie Wen 
Published: May 2022

AbstractDiabetes and related metabolic syndrome are common metabolic disorders. Gestational diabetes mellitus (GDM) is rather prevalent in the clinic. Although most GDM resolves after therapeutic intervention and/or after delivery, the long-term health effect of GDM remains to be better understood. The constitutive androstane receptor (CAR), initially characterized as a xenobiotic receptor, was more recently proposed to be a therapeutic target for obesity and type 2 diabetes mellitus (T2DM). In this study, high-fat diet (HFD) feeding was used to induce GDM. Upon delivery, GDM mice were returned to chow diet until the metabolic parameters were normalized. Parous non-GDM control females or metabolically normalized GDM females were then subjected to HFD feeding to induce nongestational obesity and T2DM. Our results showed that GDM sensitized mice to metabolic abnormalities induced by a second hit of HFD. Treatment with the CAR agonist 1,4-bis [2-(3,5 dichloropyridyloxy)] benzene efficiently attenuated GDM-sensitized and HFD-induced obesity and T2DM, including decreased body weight, improved insulin sensitivity, inhibition of hyperglycemia and hepatic steatosis, increased oxygen consumption, and decreased adipocyte hypertrophy. In conclusion, our results have established GDM as a key risk factor for the future development of metabolic disease. We also propose that CAR is a therapeutic target for the management of metabolic disease sensitized by GDM.
Primary Hyperparathyroidism From Ectopic Parathyroid Adenoma in a 12-Year-Old With Slipped Capital Femoral Epiphysis
Authors: Vitale Rebecca J , Shieh Hester F , Modi Biren P , Gordon Rebecca J 
Published: May 2022

Abstract
Primary hyperparathyroidism has been reported in pediatric patients presenting with slipped capital femoral epiphysis (SCFE), but never in patients with ectopic parathyroid adenoma. A 12-year-old boy with obesity and autism spectrum disorder presented with a limp and was found to have bilateral SCFE. Calcium was elevated to 12.3 mg/dL with parathyroid hormone (PTH) of 1191 pg/mL. Neck ultrasound revealed no parathyroid adenoma. He was discharged following bilateral surgical pinning with plans for outpatient workup. Repeat labs 5 days later demonstrated calcium had risen to 16.7 mg/dL. Technetium-99m sestamibi scintigraphy and a computed tomography scan revealed a 2.7 × 1.6 × 1.9 cm intrathymic mediastinal lesion. He underwent a thoracoscopic resection of the mass, and intraoperative PTH levels fell appropriately. Pathology revealed a parathyroid adenoma. Postoperatively, the patient developed hungry bone syndrome followed by normocalcemic secondary hyperparathyroidism which resolved with high-dose vitamin D supplementation. Primary hyperparathyroidism presenting as SCFE in a pediatric patient has been reported in 13 previous cases. This is the first reported case of bilateral SCFE arising from an ectopic parathyroid adenoma. Thoracoscopic resection is a relatively new approach in pediatrics. Primary hyperparathyroidism can be associated with SCFE, especially bilateral, and should be considered in patients with traditional risk factors for SCFE. Pediatric patients with primary hyperparathyroidism and negative neck imaging should be further evaluated for ectopic parathyroid adenomas with nuclear medicine or cross-sectional imaging that includes the head, neck, and mediastinum. Thoracoscopic resection can be considered in pediatric patients with mediastinal ectopic parathyroid adenoma.
Evaluation of additive manufacturing processes in the production of oculo-palpebral prosthesis
Authors: Eyzaguirre Diego , Salazar-Gamarra Rodrigo , Binasco Lengua Salvatore , Lauria Dib Luciano 
Published: May 2022

Background: Prosthetic restorations are made to adapt or attach missing human parts in order to restore function and appearance. Maxillofacial defects connote a greater impact on patients, since the face cannot be concealed, and all the senses of the human body are expressed in it. Therefore, in order to restore the patient’s quality of life, they are the ones that require the best possible adaptation to the characteristics of the patients. Methods: For the maxillofacial prostheses to fit patients, they must be personalized for each patient. The NGO “Mais Identidade” is a multidisciplinary team that specializes in the rehabilitation of patients with maxillofacial trauma. They use digital manufacturing as a tool to manufacture personalized maxillofacial prostheses for patients. With the help of the NGO, the following research is conducted with the purpose of evaluating different methods of additive manufacturing, 3D printing, in order to select the equipment that suits the needs of the method used in the manufacture of maxillofacial prostheses. To this end, eyelid models will be manufactured in different additive manufacturing equipment, and these will be evaluated according to their economic, physical, and aesthetic characteristics.
Analysis of contact tracing surveillance for COVID-19 among healthcare workers in secondary referral hospital, Indonesia
Authors: Asmarawati Tri Pudy , Sukartini Tintin , Ekasari Ardhena , Sofia Devi Rahma , Kamariyah Nurul , Novendrianto Dwiki , Yuliasari Putri , Rusca P Kuswantoro , Acob Joel Rey , Windradi Choirina , Mahdi Bagus Aulia , Martani Okla Sekar , Agustin Esthiningrum Dewi 
Published: May 2022

Background: Healthcare workers (HCWs) are more vulnerable to COVID-19 infection. Tracing and screening cases among healthcare workers are essential to overcome the spread of COVID-19. We held surveillance at the second-referral hospital in Surabaya, Indonesia, to inspect the associating factors of infected HCWs. Methods: From 776 HCWs, we conducted a structured retrospective review of all COVID-19-confirmed HCWs and ones having contact with COVID-19 patients between February-July 2021. We associated general characteristics (i.e age, gender, working sites, etc) of the sample with the positive cases, analyzed the vaccination status, then did bivariate and multivariate regression logistic analyses to determine related factors putting HCWs at risk for COVID-19 infection. Results: Bivariate analysis significantly revealed that 72.86% patients had a close contact (OR = 2.61; p<0.05), with medical staffs as the most frequent source (85.71%; OR = 2.19; p=0.033), for > 15 minutes contact duration (90%; OR = 1.1; p<0.05). Healthcare workers wearing proper PPE (N-95 and face shields) were significantly less exposed to COVID-19 (OR = 0.47; p<0.05; and OR = 0.46; p<0.05). Even fully-vaccinated samples were still prone to infection. (OR=1.25; p= 0.042). Common symptoms consisted of fever, rhinorrhea, sore throat, and vomiting (p=0.025l p=0.002; p<0.05; p=0.002). Multivariate regression logistic analysis disclosed that the use of N95 masks, contact duration >15 minutes, and the vaccine were the most influential factors (aOR = 1.72. 95% CI (1.029-2.88); aOR = 3.92. 95% CI (1.75-8.78); aOR = 0.39. 95% CI (0.13-0.82 )) Conclusions: Close contact, lack of compliance in wearing N95 masks, and unvaccinated status are risk factors for COVID-19 exposure to HCWs; thus, to achieve maximum prevention of intra-hospital transmission, the use of N-95 masks, contact avoidance, and vaccination, along with immediate tracing and strict health-protocols are all compulsory.
Planowanie aktywności ruchowej oraz korzyści z niej płynące u osób po 60. roku życia
Authors: Gałuszka Aleksandra 
Published: May 2022

Starzenie się człowieka jest naturalnym procesem, nieodwracalnym, wywołującym zmiany w każdym z układów organizmu człowieka. Wiążąe się ze stopniowym narastaniem zmian na poziomach: biologicznym, psychicznym oraz społecznym. W efekcie tych złożonych i jednocześnie nieodwracalnych procesów naturalnych dochodzi do osłabienia możliwości regeneracyjnych i psychofizycznych organizmu ludzkiego, które dodatkowo są ograniczone poprzez przebyte w ciągu życia choroby czy urazy. U ludzi w wieku geriatrycznym sprawność fizyczna i psychiczna jest zróżnicowana, a występujące niedomogi w psychice i motoryce wymuszają indywidualne zlecanie ćwiczeń dostosowanych do ogólnego stanu zdrowia chorego oraz okresu choroby. Mnogość dostępnych form ruchu umożliwia dopasowanie ćwiczeń do konkretnych potrzeb. U osób w podeszłym wieku i cierpiących na dolegliwości ważnym zagadnieniem staje się profilaktyka wtórna i trzeciorzędowa, czyli przestrzeganie obowiązujących zasad w leczeniu podstawowej jednostki chorobowej oraz chorób współistniejących. Aktywność fizyczna u osób starszych powinna oddziaływać w obszarach takich jak: wytrzymałość, siła, równowaga, gibkość. Ważny jest właściwy dobór aktywności aby były one możliwe do wykonania w związku z występującymi schorzeniami oraz by sprawiały ćwiczącemu przyjemność.