bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving transparency—A call to include social housing information in biomedical research articles involving nonhuman primates
Authors: Pomerantz Ori , Baker Kate C. , Bellanca Rita U. , Bloomsmith Mollie A. , Coleman Kristine , Hutchinson Eric K. , Pierre Peter J. , Weed James L. ,   National Primate Research Centers' Behavioral Management Consortium
Published: April 2022

AbstractThe social setting of animal subjects in the research environment has known effects on a variety of dependent measures used in biomedical research. Proper evaluation of the robustness of published research is dependent upon transparent, detailed, and accurate reporting of research methods, including the animals' social housing conditions. However, to date, most research articles utilizing nonhuman primates (NHPs) provide only partial data on this topic, hampering transparency, and reproducibility. Therefore, we call for the inclusion of information pertaining to the social aspects of the animals' housing conditions in publications involving NHPs to improve transparency. We argue that including this information in scientific publications is crucial for the interpretation of research findings in the appropriate context and for understanding unexplained variability in study findings. Finally, the inclusion of this information in publications will additionally familiarize scientists with how other researchers conducting similar studies are housing their animals and will encourage them to consider the implications of various housing conditions on their research outcomes
Reversing a Platinum Micromotor by Introducing Platinum Oxide
Authors: Lyu Xianglong , Chen Jingyuan , Liu Jiayu , Peng Yixin , Duan Shifang , Ma Xing , Wang Wei 
Published: April 2022

AbstractUnderstanding and controlling the swimming direction of a synthetic nano‐ and micromotor holds fundamental and applied significance. Here, we focus on platinum‐containing Janus colloids that catalytically decompose H2O2into O2, an archetypical model of chemical micromotor. We discover that platinum oxides (primarily PtO) are produced on Pt films sputter‐coated in O2plasma, and PtO reverses the motor possibly by self‐electrophoresis. Using this knowledge, micromotors moving in either direction were fabricated by intentionally introducing or removing PtO. These findings challenge the conventional wisdom that a Pt micromotor is powered by Pt alone, and open up new avenues for controlling the swimming directions of a micro‐ and nanomachine.
Inferring the demographic history of Japanese eel (Anguilla japonica) from genomic data: Insights for conservation and fisheries management
Authors: Faulks Leanne , Kaushik Prashant , Taniguchi Shoji , Sekino Masashi , Nakamichi Reiichiro , Yamamoto Yuki , Fujimori Hiroka , Okamoto Chiaki , Kodama Sakie , Daryani Ayu , Manwong Angel Faye , Galang Ishmerai , Mochioka Noritaka , Araki Kiyo , Suzuki Motoo , Kaji Yoshitsugu , Ichiki Takumi , Matsunaga Tetsuya , Hakoyama Hiroshi 
Published: April 2022

Abstract

Assessing the status or population size of species is a key task for wildlife conservation and the sustainable management of harvested species. In particular, assessing historical changes in population size provides an evolutionary perspective on current population dynamics.
Japanese eel (Anguilla japonica) is an endangered yet commercially important catadromous fish species. This article assesses the demographic history of Japanese eel using the pairwise and multiple sequentially Markovian coalescent methods.
The analyses indicate a reduction in effective population size Ne from 38,000 to 10,000 individuals between 4 and 1 Mya, followed by an increase to 80,000 individuals between 1 Mya and 22–30 kya. Approximately 22–30 kya there is evidence for a reduction in Ne to approximately 60,000 individuals. These events may be related to changes in environmental conditions, especially around the last glacial maximum (19–33 kya).
The results of this study suggest that Japanese eel has experienced at least two population bottlenecks, interspersed by a period of population growth. The overall level of genetic diversity is relatively low, although there is no evidence for inbreeding. Data from this study will be used to help model the extinction risk of Japanese eel.
Two new stick insect species of Sosibia Stål (Phasmatodea: Lonchodidae: Necrosciinae) from China and the first report on mitochondrial genomes of this genus
Authors: Li Yanfei , Wang Shujing , Chen Juhong , Zhou Jiayue , Bu Wenjun 
Published: April 2022

AbstractWe describe and illustrate two new species of Sosibia from China: Sosibia gibba sp. nov. and Sosibia ovata sp. nov. This report includes a key to Sosibia species from China and a description of the distribution area in China. The two mitochondrial genomes of these new Sosibia species were sequenced and annotated for the first time. The compositional biases, codon usage, nucleotide composition, and construct tRNA secondary structures of the two mitogenomes were analyzed. The phylogenetic relationships based on the mitogenomes using Bayesian inference and maximum likelihood methods supported the monophyly of Necrosciinae and divided it into two distinct clades: A: (Sipyloidea + [Sosibia + Calvisia]); and B: (Neohirasea + Micadina).
Aryldiazonium Salts and DABSO: A Versatile Combination for Three‐Component Sulfonylative Cross‐Coupling Reactions
Authors: Das Pritha , Das Subhodeep , Jana Ranjan 
Published: April 2022

AbstractA combination of aryldiazonium salts and DABSO provides a unique opportunity for sulfonylative multicomponent cross‐coupling reactions. Here, a copper‐catalyzed three‐component cross‐coupling of aryldiazonium salts, DABSO with arylboronic acids to obtain medicinally relevant unsymmetrical diarylsulfones is disclosed. Interestingly, a catalyst‐free approach for the synthesis of arylvinylsulfones from the corresponding vinyl boronic acids or vinyl halides is explored under basic condition. Tethered aryldiazonium salts provided the corresponding annulated alkylvinylsulfones via alkene difunctionalization under the same transition metal‐free condition. Mechanistically, these multicomponent reactions proceed through a single electron pathway by the formation of arylsulfonyl radical as a key intermediate.
The influence of governance structure on the relationship between pay ratio and environmental and social performance
Authors: Mahmoudian Fereshteh , Jermias Johnny 
Published: April 2022

AbstractThis study investigates the moderating effects of two specific governance structures, board independence and CEO duality, on the relationship between the pay ratio and environmental and social performance. Controlling for the endogeneity of the pay ratio and employees' performance and skills, we use a sample of companies listed on ExecuComp (S&P1500) and apply the 3SLS method to test interaction effects. We find that board independence moderates the negative relationship between the pay ratio and environmental and social performance. Furthermore, the effect of board independence on the relationship between the pay ratio and environmental and social performance decreases when the CEO is also the chair. These results suggest that independent directors moderate the negative effects of the pay ratio on firms' environmental and social performance. Finally, the concentration of power through CEO duality decreases the effectiveness of board monitoring.
Nanocomposite hydrogels for biomedical applications
Authors: Huang Shanghui , Hong Xiangqian , Zhao Mingyi , Liu Nanbo , Liu Huiling , Zhao Jun , Shao Longquan , Xue Wei , Zhang Han , Zhu Ping , Guo Rui 
Published: April 2022

AbstractNanomaterials' unique structures at the nanometer level determine their incredible functions, and based on this, they can be widely used in the field of nanomedicine. However, nanomaterials do possess disadvantages that cannot be ignored, such as burst release, rapid elimination, and poor bioadhesion. Hydrogels are scaffolds with three‐dimensional structures, and they exhibit good biocompatibility and drug release capacity. Hydrogels are also associated with disadvantages for biomedical applications such as poor anti‐tumor capability, weak bioimaging capability, limited responsiveness, and so on. Incorporating nanomaterials into the 3D hydrogel network through physical or chemical covalent action may be an effective method to avoid their disadvantages. In nanocomposite hydrogel systems, multifunctional nanomaterials often work as the function core, giving the hydrogels a variety of properties (such as photo‐thermal conversion, magnetothermal conversion, conductivity, targeting tumor, etc.). While, hydrogels can effectively improve the retention effect of nanomaterials and make the nanoparticles have good plasticity to adapt to various biomedical applications (such as various biosensors). Nanocomposite hydrogel systems have broad application prospects in biomedicine. In this review, we comprehensively summarize and discuss the most recent advances of nanomaterials composite hydrogels in biomedicine, including drug and cell delivery, cancer treatment, tissue regeneration, biosensing, and bioimaging, and we also briefly discussed the current situation of their commoditization in biomedicine.
Interagency collaboration among community organizations serving children and families in child welfare
Authors: Kothari Brianne H. , Fischer Cameron , Mullican Nicole , Lipscomb Shannon T. , Jaramillo Jamie 
Published: April 2022

AbstractTransformational change to address adversity and nurture resilience requires deep and sustained community collaborations. Interagency collaboration is critically important for child welfare especially during crisis situations. It is clear that when agencies focus on strengths and promote protective factors (individual, familial and community‐level) in time, negative consequences of maltreatment are reduced and well‐being outcomes are enhanced. However, limited research is available to effectively inform community organizations and collective impact initiatives about how they can strengthen interagency collaboration and collaborative practice. Furthermore, the coronavirus disease 2019 (COVID‐19) pandemic elevates the urgency to understand how community organizations work together to serve children and families as it threatens access to safety nets. This mixed methods study examined interagency collaboration among community organizations in a collective impact workgroup focussed on children and families involved in the child welfare system. Results revealed key strengths to collaboration (e.g., strong connections, resource sharing, resilience in staff, more vulnerable children accessing resources and more adults engaged in serving this population) as well as barriers to collaboration (e.g., group composition, funding and lack of clarity/focus). Results also revealed specific ways in which this pandemic has impacted efforts to serve children and families in child welfare. Findings highlight an approach that might assist interagency collaboratives. In addition, findings were also translated into concrete action items that might be helpful to interagency collaboratives focussed on child welfare.
Outcomes of rotational atherectomy followed by cutting balloon versus plain balloon before drug‐eluting stent implantation for calcified coronary lesions: A meta‐analysis
Authors: Patel Neelkumar , Bandyopadhyay Dhrubajyoti , Agarwal Gaurav , Chakraborty Sandipan , Kumar Ashish , Hajra Adrija , Amgai Birendra , Krittanawong Chayakrit , Martin Lily , Abbott J. Dawn , Mamas Mamas A. , Naidu Srihari S. 
Published: April 2022

AbstractObjectiveThe aim of this study is to compare outcomes of rotational atherectomy and cutting balloon (RACB) versus rotational atherectomy and plain balloon (RAPB) before drug‐eluting stent (DES) implantation in calcified coronary lesions.MethodsRandomized controlled trials (RCT) and observational studies comparing RACB with RAPB were identified through a systematic search of published literature across multiple databases. Random effect meta‐analysis was performed to compare the outcome between the two groups.ResultsFour studies were included in the meta‐analysis (three observational and one RCT) involving a total of 315 patients. 166 patients had RACB, and 149 patients had RAPB before DES placement with a median follow‐up of 11.5 months. Compared with patients who had RAPB there was no difference in MACE (composite of death, myocardial infarction, and target vessel revascularization) (odds ratio [OR]: 0.74; 95% confidence interval [CI]: 0.25–2.18], slow flow/no reflow (OR: 0.71; 95% CI: 0.23–2.16), all‐cause mortality (OR: 2.02; 95% CI: 0.28–14.60), and device success rate (OR: 1.79; 95% CI: 0.28–11.18) in the RACB approach. There was a benefit towards less target lesion revascularization in the RACB group; however, this outcome was reported in two studies (OR: 0.29; 95% CI: 0.08–0.99). On meta‐regression there was no association between age, sex, diabetes, or lesion location with MACE and all‐cause mortality. The studies were homogenous across all outcomes.ConclusionRACB, as compared with RAPB, had a similar risk of MACE, all‐cause mortality, device success, and complication, but a lower risk of target lesion revascularization.
Angiography‐derived versus invasively‐determined index of microcirculatory resistance in the assessment of coronary microcirculation: A systematic review and meta‐analysis
Authors: Fernández‐Peregrina Estefania , Garcia‐Garcia Hector M. , Sans‐Rosello Jordi , Sanz‐Sanchez Jorge , Kotronias Rafail , Scarsini Roberto , Echavarria‐Pinto Mauro , Tebaldi Matteo , De Maria Giovanni L. 
Published: April 2022

AbstractBackgroundThe index of microvascular resistance (IMR) is an established tool to assess the status of coronary microcirculation. However, the need for a pressure wire and hyperemic agents have limited its routine use and have led to the development of angiography‐derived pressure‐wire‐free methods (angiography‐derived IMR [IMRAngio]). In this review and meta‐analysis, we aim to assess the global diagnosis accuracy of IMRAngio versus IMR.MethodsA systematic review of the literature was performed. Studies directly evaluating IMRAngio versus IMR were considered eligible. Pooled values of diagnostic test and summary receiver operator curve were calculated.ResultsSeven studies directly comparing IMRAngio versus IMR were included (687 patients; 807 vessels). Pooled sensitivity, specificity, +likelihood ratio (LR), and −LR were 82%, 83%, 4.5, and 0.26 respectively. Pooled accuracy was 83% while pooled positive predictive value and negative predictive value were 76% and 85%, respectively. Comparable results were obtained when analyzing by clinical scenario (acute and nonacute coronary syndromes).ConclusionIMRAngio shows a good diagnostic performance for the prediction of abnormal IMR.
Ligand‐Promoted, Enantioconvergent Synthesis of Aliphatic Alkanes Bearing Trifluoromethylated Stereocenters via Hydrotrifluoroalkylation of Unactivated Alkenes
Authors: He Yan , Bian Kang‐Jie , Wu Bing‐Bing , Liu Peng , Ni Shan‐Xiu , Wang Xi‐Sheng 
Published: April 2022

Comprehensive SummaryWhile drug chirality remains one of the most important themes in medicinal chemistry and fluorine‐containing drugs have comprised large portion of global pharmaceutical market, the synthesis of fluorine‐containing compounds featuring a trifluoromethylated stereogenic carbon center is still underdeveloped. Recent strategy of enantioconvergent cross‐coupling of trifluoromethylated alkyl halide has significantly updated previous toolbox that is dependent on additional functional group to achieve desired bond formation and highly enantioselective control. However, evident limitations were present in specific coupling candidate (sp2 carbon) and/or prerequisite heteroatom in trifluoroalkyl source for inducing effective stereoconvergent differentiation. Leveraging novel design of sterically hindered bisoxazoline ligand and drastic increase of molecular complexity of in situ generated sp3 coupling partner via metal‐hydride atom transfer, herein, we report a nickel‐catalyzed, highly enantioselective hydrotrifluoroalkylation of unactivated alkenes for diverse synthesis of enantioenriched aliphatic alkanes featuring trifluoromehylated stereogenic carbon. Excellent stereochemical control (mostly >95: 5 er), high catalytic reactivity, mild conditions, and broad substrate scope (40+ examples), enable convenient late‐stage asymmetric trifluoroalkylation of various biologically active complex molecules.
Comparative distribution ofArcadlin/Protocadherin‐8mRNA in the intact and ischemic brains of adult mice
Authors: Inoue Yosuke , Sawano Toshinori , Yamaguchi Natsumi , Inoue Shota , Takayama Akinori , Nakazawa Shuma , Inagaki Shinobu , Nakatani Jin , Tanaka Hidekazu 
Published: April 2022

AbstractThe structural plasticity of dendritic spines serves as the adaptive capabilities of the central nervous system to various stimuli. Among these stimuli, cerebral ischemia induces dynamic alterations in neuronal network activity. Arcadlin/Paraxial protocadherin/Protocadherin‐8 (Acad), a regulator of dendritic spine density, is strongly induced by activating stimuli to the neurons. However, the detailed distribution of Acad in normal and ischemic adult brains remains unclear. We comprehensively describedAcadexpression patterns in normal and ischemic adult brains by in situ hybridization histochemistry. We found that intact adult brains expressedAcadin the piriform cortex, dentate gyrus, hippocampal CA3, entorhinal cortex, amygdala, and hypothalamus.Acadexpression was dramatically upregulated in the piriform cortex, olfactory area, dentate gyrus, entorhinal cortex, prefrontal cortex, insular cortex, amygdala, and septohippocampal nucleus 4 h after cerebral ischemia. Cerebral ischemia induced widespread neuronal activation, which was required forAcadupregulation. Our data suggested the involvement of Acad in the adaptive plasticity and remodeling of the neuronal network in the limbic and paralimbic systems.
Advanced Carbon‐Based Nanocatalysts and their Application in Catalytic Conversion of Renewable Platform Molecules
Authors: Chen Zemin , Zeng Xiang , Wang Shenyu , Cheng Aohua , Zhang Ying 
Published: April 2022

AbstractThe transformation of renewable platform molecules to produce value‐added fuels and fine‐chemicals is a promising strategy to sustainably meet future demands. Owing to their finely modified electronic and geometric properties, carbon‐based nanocatalysts have shown great capability to regulate their catalytic activity and stability. Their well‐defined and uniform structures also provide both the opportunity to explore intrinsic reaction mechanisms and the site‐requirement for valorization of renewable platform molecules to advanced fuels and chemicals. This Review highlights the progress achieved in carbon‐based nanocatalysts, mainly by using effective regulation approaches such as heteroatom anchoring, bimetallic synergistic effects, and carbon encapsulation to enhance catalyst performance and stability, and their applications in renewable platform molecule transformations. The foundation for understanding the structure‐performance relationship of carbon‐based catalysts has been established by investigating the effect of these regulation methods on catalyst performance. Finally, the opportunities, challenges and potential applications of carbon‐based nanocatalysts are discussed.
Quantification of thyroid hormones and analogs by liquid chromatography coupled to mass spectrometry. Preliminary results in athletes and non‐athletes serum samples
Authors: Martínez Brito Dayamin , Leogrande Patrizia , Donati Francesco , de la Torre Xavier , Botrè Francesco 
Published: April 2022

AbstractThis paper aimed to assess a method to measure eight thyroid‐related compounds in serum by liquid chromatography‐mass spectrometry (LC‐MS/MS), to verify the correlation with radioimmunoassay (RIA), to evaluate the possible cross‐reactivity, and to observe differences between athletes declaring the consumption of sodium levothyroxine and nonathletes serum samples. Validation was carried out to assess carryover, working range and linearity, limit of detection and limit of quantification, precision, matrix influence, recovery, accuracy, and uncertainty. Comparison between RIA and LC‐MS/MS results was done. The assay was applied to serum samples, and comparison with RIA was done for T3 and T4 levels supported by RIA Thyroid‐stimulating hormone (TSH) measurements. Validation parameters showed satisfactory results. Correlation between RIA and LC‐MS/MS for T3 and T4 showed good results, but a cross‐reactivity between T3 and T3AA was observed. Although no significant differences were proved, preliminary comparison between athletes and nonathletes serum samples showed a shift towards high values of TSH and lower for T4 values in the athletes' group. Differences between thyronine and T4AA concentrations and ratios were observed. The trend of T4 values supported by TSH measures might indicate subclinical hypothyroidism in athletes. This represents one of the most controversial thyroid statuses as different criteria about its treatment are described, especially since one of the exogenous causes is inadequate levothyroxine therapy. Because the variation of thyroid hormones and TSH has been extensively studied in high‐performance sports, it is worth considering the need to set an adequate reference interval to accurately assess the thyroid status in athletes.
An approach to defining and achieving restoration targets for a threatened plant community
Authors: Elliott C. P. , Commander L. E. , Merino‐Martín L. , Golos P. J. , Stevens J. , Miller B. P. 
Published: April 2022

AbstractConnecting scientific research and government policy is essential for achieving objectives in sustaining biodiversity in an economic context. Our approach to connecting theoretical ecology, applied ecology, and policy was devised using principles of restoration ecology and the requisite methodology to restore biodiverse ecosystems. Using a threatened ecological community (TEC) with >120 plant species, we posit our approach as a guide for interpreting and achieving regulatory compliance (i.e., government conditions) enacted to manage or offset environmental impacts of development. We inform the scientific approach necessary to delivering outcomes appropriate to policy intent and biodiverse restoration through theoretical and applied research into the ecological restoration of the highly endemic flora of banded ironstone formations of the Mid West of Western Australia. Our approach (1) defines scale‐appropriate restoration targets that meet regulatory compliance (e.g., Government of Western Australia Ministerial Conditions); (2) determines the optimal method to return individual plant species to the restoration landscape; (3) develops a conceptual model for our system, based on existing restoration frameworks, to optimize and facilitate the pathway to the restoration of a vegetation community (e.g., TEC) using diverse research approaches; and (4) develops an assessment protocol to compare restoration achievements against the expected regulatory outcomes using our experimental restoration trials as a test example. Our approach systematically addressed the complex challenges in setting and achieving restoration targets for an entire vegetation community, a first for a semiarid environment. We interpret our approach as an industry application relevant to policy‐ or regulator‐mediated mine restoration programs that seek to return biodiverse species assemblages at landscape scales.