bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using implementation mapping to develop strategies for preventing non-communicable diseases in Japanese small- and medium-sized enterprises
Authors: Odawara Miyuki , Saito Junko , Yaguchi-Saito Akiko , Fujimori Maiko , Uchitomi Yosuke , Shimazu Taichi 
Published: October 2022

IntroductionWorkplace programs to prevent non-communicable diseases (NCDs) in the workplace can help prevent the incidence of chronic diseases among employees, provide health benefits, and reduce the risk of financial loss. Nevertheless, these programs are not fully implemented, particularly in small- and medium-sized enterprises (SMEs). The purpose of this study was to develop implementation strategies for health promotion activities to prevent NCDs in Japanese SMEs using Implementation Mapping (IM) to present the process in a systematic, transparent, and replicable manner.MethodsQualitative methods using interviews and focus group discussions with 15 SMEs and 20 public health nurses were conducted in a previous study. This study applied the Consolidated Framework for Implementation Research and IM to analyze this dataset to develop implementation strategies suitable for SMEs in Japan.ResultsIn task 2 of the IM, we identified performance objectives, determinants, and change objectives for each implementation stage: adoption, implementation, and maintenance; to identify the required actors and actions necessary to enhance implementation effectiveness. Twenty-two performance objectives were identified in each implementation stage. In task 3 of the IM, the planning group matched behavioral change methods (e.g., modeling and setting of graded tasks, framing, self-re-evaluation, and environmental re-evaluation) with determinants to address the performance objectives. We used a consolidated framework for implementation research to select the optimal behavioral change technique for performance objectives and determinants and designed a practical application. The planning team agreed on the inclusion of sixteen strategies from the final strategies list compiled and presented to it for consensus, for the overall implementation plan design.DiscussionThis paper provides the implementation strategies for NCDs prevention for SMEs in Japan following an IM protocol. Although the identified implementation strategies might not be generalizable to all SMEs planning implementation of health promotion activities, because they were tailored to contextual factors identified in a formative research. However, identified performance objectives and implementation strategies can help direct the next steps in launching preventive programs against NCDs in SMEs.
Transcutaneous electrical nerve stimulation over acupoint for chronic obstructive pulmonary disease: A systematic review and meta-analysis
Authors: Wei Ying , Yuan Nairong , Dong Yan , Wang Lixia , Ding Jiru 
Published: October 2022

BackgroundTranscutaneous electrical nerve stimulation over an acupoint (acu-TENS), a new technique applied in pulmonary rehabilitation programs, has been gradually used in the management of chronic obstructive pulmonary disease (COPD). However, the effects of acu-TENS have not been fully evaluated. Therefore, this review was conducted to assess the effects of acu-TENS on COPD.MethodsA total of seven electronic databases were searched from their inception to September 2021 for randomized controlled trials of acu-TENS for COPD. Two investigators independently performed data extraction and methodological quality assessment. Heterogeneity was examined by Cochrane χ2 and I2 tests. The source of heterogeneity was investigated by subgroup analysis or sensitivity analysis.ResultsIn our review, ten studies between 2008 and 2021 were included. The aggregated results indicated that acu-TENS showed positive effects in forced expiratory volume in 1 s (FEV1) [MD = 0.13 L, 95% CI (0.11–0.16), P &lt; 0.00001], FEV1% predicted [MD = 5.92%, 95% CI (3.43–8.41), P &lt; 0.00001], 6-min walk distance (6MWD) [MD = 14.68m, 95% CI (6.92–22.44), P = 0.0002], dyspnea visual analog scale (DVAS) [MD = −7.58, 95%CI (−14.33 to −0.84), P = 0.03], modified Borg scale (MBS) [MD = −0.46, 95% CI (−0.86 to −0.06), P = 0.03], and COPD assessment test (CAT) [MD = −4.25, 95% CI (−5.24 to −3.27), P &lt; 0.00001]. Although six studies reported adverse effects, only one patient had shoulder pain after acu-TENS.ConclusionAcu-TENS seems to be effective in improving pulmonary function and health status in patients with COPD, with little effect on exercise capacity and dyspnea. However, this result should be interpreted with caution, and high-quality RCTs were needed for further verification.
Chronic health effects associated with electronic cigarette use: A systematic review
Authors: Wasfi Rania A. , Bang Felix , de Groh Margaret , Champagne Andre , Han Arum , Lang Justin J. , McFaull Steven R. , Melvin Alexandria , Pipe Andrew Lawrence , Saxena Shika , Thompson Wendy , Warner Emily , Prince Stephanie A. 
Published: October 2022

IntroductionOver the last decade, e-cigarette use has been on the rise but with growing health concerns. The objective of this systematic review was to update findings for chronic health outcomes associated with e-cigarette use from the 2018 National Academies of Sciences, Engineering, and Medicine (NASEM) report.MethodsThree bibliographic databases were searched to identify studies comparing the chronic health effects of e-cigarette users (ECU) to non-smokers (NS), smokers, and/or dual users indexed between 31 August 2017 and 29 January 2021. Two independent reviewers screened abstracts and full texts. Data were extracted by one reviewer and verified by a second one. Outcomes were synthesized in a narrative manner using counts and based on statistical significance and direction of the association stratified by study design and exposure type. Risk of bias and certainty of evidence was assessed. The protocol was prospectively registered on Open Science Framework https://osf.io/u9btp.ResultsA total of 180 articles were eligible. This review focused on 93 studies for the 11 most frequently reported outcomes and from which 59 reported on daily e-cigarette use. The certainty of evidence for all outcomes was very low because of study design (84% cross-sectional) and exposure type (27% reported on exclusive ECU, i.e., never smoked traditional cigarettes). Overall, the summary of results for nearly all outcomes, including inflammation, immune response, periodontal and peri-implant clinical parameters, lung function, respiratory symptoms, and cardiovascular disease, suggested either non-significant or mixed results when daily ECU was compared to NS. This was also observed when comparing exclusive ECU to NS. The only notable exception was related to oral health where most (11/14) studies reported significantly higher inflammation among daily ECU vs. NS. Compared to the smokers, the exclusive-ECUs had no statistically significant differences in inflammation orperiodontal clinical parameters but had mixed findings for peri-implant clinical parameters.ConclusionsThis review provides an update to the 2018 NASEM report on chronic health effects of e-cigarette use. While the number of studies has grown, the certainty of evidence remains very low largely because of cross-sectional designs and lack of reporting on exclusive e-cigarette exposure. There remains a need for higher quality intervention and prospective studies to assess causality, with a focus on exclusive e-cigarette use.
Analysis of upper atmospheric effects on material per onboard atomic oxygen monitor system of SLATS
Authors: Kimoto Yugo , Tsuchiya Yuta , Miyazaki Eiji , Goto Aki , Yukumatsu Kazuki , Imamura Shunsuke 
Published: October 2022

JAXA has proposed an innovative idea for satellites in Low Earth Orbit (LEO). The Super-Low Altitude Test Satellite (SLATS), also known as TSUBAME, is the first Earth observation satellite to occupy a Super-Low Orbit (S-LEO) or Very Low Earth Orbit (VLEO), below 300 km. The purposes of SLATS are 1) testing the maintenance of the satellite’s altitude with its ion engine against high atmospheric drag at a super-low altitude, 2) acquiring data on atmospheric density and atomic oxygen (AO), and 3) testing optical Earth observation. SLATS was successfully launched on 23 December 2017. SLATS was then altitude-controlled for 636 days to 271.7 km using chemical thrusters, aerodynamic drag, and ion engine propulsion. SLATS finally maintained its orbit of 167.4 km for 7 days and finished its operation on 1 October 2019. All the SLATS and Atomic oxygen MOnitor (AMO) data was acquired during these operations. The AMO is one of the mission sensors that monitor AO and its effects on spacecraft materials. The data from the AMO contributes to the choice of materials in future S-LEO satellite design. The data obtained by the AMO are valuable in that they provide considerable knowledge on AO fluence and its effects on space materials. A precise atmospheric density model and atmospheric composition model are indispensable for predicting the trajectory or re-entry of debris in orbit. Atmospheric models such as NRLMSISE-00, JB 2008, and DTM2013 have been developed, but few studies compare these models and the actual atmospheric environment in LEO. The average atmospheric density obtained from SLATS is lower than the value predicted by the atmospheric models (NRLMSISE-00, JB 2008, and DTM 2013). Understanding the model’s accuracy will contribute to the orbit control of future S-LEO satellites and the orbit prediction and control of debris in LEO.
Laparoscopic intersphincteric resection vs. transanal total mesorectal excision in overweight patients with low rectal cancer
Authors: Li Zhengbiao , Wang Qi , Feng Qingbo , Wang Xingqin , Xu Fujian , Xie Ming 
Published: October 2022

ObjectiveAnus-preserving surgery in overweight patients with low rectal cancer has been a challenge due to the narrow operating space. Intersphincteric resection (ISR) was once a standard therapeutic option for low rectal cancer. The effectiveness of transanal total mesorectal excision (taTME) in treating this group of patients remains uncertain as a new surgical strategy. The aim of this study was to evaluate the short-term effects of taTME with ISR in overweight patients with low rectal cancer.MethodsA total of 53 patients with low rectal cancer were treated with taTME in 31 cases and ISR in 22 cases. The surgery-related data, pathological manifestations of surgical specimens, postoperative recovery, and postoperative complications were compared.ResultsPatients in both groups completed the surgery successfully. There were no significant differences in operative time, blood loss, anastomotic distance from the anal verge and ileostomy between the two groups (P &gt; 0.05). TaTME group performed or virtually finished resection of the rectal mesentery, and no positive cases of Circumferential Resection Margin (CRM) or Distal Resection Margin (DRM) were detected in either group. The number of lymph nodes found in surgical specimens did not change significantly between the two groups (P = 0.391). In the subgroup analysis, however, more lymph nodes were detected in female patients undergoing taTME than in male patients (P = 0.028). The ISR group took less time to remove the drainage tubes (P = 0.013) and the same results were obtained in both groups of male patients in the subgroup analysis (P = 0.011). There were no statistically significant differences in time to start liquid diet, time to remove catheters, time to start flatus, time to begin ambulation, postoperative hospital stay, and readmission within 30 days after surgery between the two groups (P &gt; 0.05). However, female patients in the taTME group were initiated ambulation earlier than males in the subgroup analysis (P = 0.034). The difference was insignificant in the occurrence of postoperative complications between the two groups (P &gt; 0.05).ConclusiontaTME is safe and feasible for the treatment of overweight patients with low rectal cancer.
Patellofemoral arthroplasty in combination with high tibial osteotomy can achieve good outcome for patients with medial-patellofemoral osteoarthritis
Authors: Peng Yonggang , Lin Wei , Zhang Yufeng , Wang Fei 
Published: October 2022

BackgroundThe purpose of our study is to report on the clinical outcomes of patients who undergoing patellofemoral arthroplasty (PFA) in combination with a high tibial osteotomy (HTO). Due to this procedure's conservative and kinematics-preserving characteristics, we hypothesized that PFA in combination with HTO would result in good clinical outcomes in patients with medial and patellofemoral compartment osteoarthritis (MPFOA).MethodsPatients who underwent PFA in combination with HTO for MPFOA from January 2018 to April 2020 were included in the study. Clinical outcomes were analyzed by comparing the Knee Society Score, Oxford Knee Score, Range of Motion, and Forgotten Joint Score before and after the procedure. Radiological evaluations were also performed to assess the tibiofemoral osteoarthritis progression and implant loosening. For all tests, the value of p &lt; 0.05 was considered statistically significant.ResultsA total of nine consecutive patients who underwent PFA in combination with HTO were included. Two were males, seven were females. The average follow-up period was 2.6 ± 0.4 years. Clinical outcomes showed a significant improvement in the Knee Society Score (clinical score: 90.3 ± 8.5 and function score: 90.8 ± 7.8), Oxford Knee Score (43.6 ± 3.6), Forgotten Joint Score (71.2 ± 10.2), and knee Range of Motion (130.4 ± 8.1°) at the final follow-up. Additionally, hip–knee–ankle angle significantly decreased from −9.3 ± 2.1° preoperatively to 2.2 ± 1.2° at the final follow-up (p &lt; 0.05). There were no complications for any patient during the follow-up time.ConclusionThis study shows that patients who underwent PFA in combination with HTO for the treatment of MPFOA achieved good clinical and radiological outcomes. This combined surgery could be an effective alternative to treat MPFOA in well-selected patients.
Ryanodine receptor-active non-dioxin-like polychlorinated biphenyls cause neurobehavioral deficits in larval zebrafish
Authors: Yaghoobi Bianca , Miller Galen W. , Holland Erika B. , Li Xueshu , Harvey Danielle , Li Shuyang , Lehmler Hans-Joachim , Pessah Isaac N. , Lein Pamela J. 
Published: October 2022

Although their production was banned in the United States in 1977, polychlorinated biphenyls (PCBs) continue to pose significant risks to the developing nervous system. Perinatal exposure to PCBs is associated with increased risk of neuropsychiatric disorders, perhaps due to altered patterns of dendritic arborization of central neurons. Non-dioxin-like (NDL) PCB congeners enhance dendritic arborization of developing mammalian neurons via sensitization of ryanodine receptors (RYR). Structure-activity relationships (SAR) of RYR sensitization by PCBs have been demonstrated using mammalian and rainbow trout (Oncorhynchus mykiss) tissue homogenates. The purpose of this study is to determine whether this SAR translates to developmental neurotoxicity (DNT) of PCBs in vivo, a question that has yet to be tested. To address this gap, we leveraged a zebrafish model to evaluate the developmental neurotoxicity potential of PCBs 28, 66, 84, 95, 138, and 153, congeners previously shown to have broadly different potencies towards sensitizing RYR. We first confirmed that these PCB congeners exhibited differing potency in sensitizing RYR in zebrafish muscle ranging from negligible (PCB 66) to moderate (PCB 153) to high (PCB 95) RYR activity. Next, enzymatically dechorionated embryos were statically exposed to varying concentrations (0.1–10 μM) of each PCB congener from 6 h post-fertilization to 5 days post-fertilization (dpf). Embryos were observed daily using stereomicroscopy to assess mortality and gross malformations and photomotor behavior was assessed in larval zebrafish at 3, 4, and 5 dpf. The body burden of each PCB was measured by gas chromatography. The key findings are: 1) None of these PCBs caused death or overt teratology at the concentrations tested; 2) A subset of these PCB congeners altered photomotor behavior in larval zebrafish and the SAR for PCB behavioral effects mirrored the SAR for RYR sensitization; and 3) Quantification of PCB levels in larval zebrafish ruled out the possibility that congener-specific effects on behavior were due to differential uptake of PCB congeners. Collectively, the findings from this study provide in vivo evidence in support of the hypothesis that RYR sensitization contributes to the DNT of PCBs.
Factors Affecting COVID-19 Testing Behaviours Among the Population in South Western Nigeria
Authors: Amoo Olufemi Samuel , Tijani Bosun , Onuigbo Tochukwu Ifeanyi , Oraegbu Joy Isioma , Kareithi Dorcas Njeri , Obi Josephine Chioma , Adeniji Esther Temilade , Dosunmu Adenike Aderonke , Karera Steven , Filani Temi , Akinreni Temidayo , Ezike Emmanuella , Owoseni Kehinde , Audu Rosemary Ajuma , Salako Babatunde Lawal 
Published: October 2022

Objectives: The objective of this study was to assess the factors affecting testing behaviours amongst the population in Ondo and Lagos States.Methods: A cross-sectional study involving 704 individuals who were considered eligible for COVID-19 testing in 4 local governments in Lagos (307) and Ondo (397) states in Nigeria, was conducted from April-June 2021. Respondents were selected using simple random sampling. A close-ended questionnaire was administered using a digital survey platform known as SurveyCTO. Data were analyzed using R 4.1.0.Results: In Lagos state, 52.4% were females, 47.2% were males while in Ondo, 55.2% were females, 44.6% were male. Chi-square tests of association revealed that socio demographic factors significantly associated with testing patterns was education level in Lagos, and none in Ondo. Testing behavior associated with testing patterns included awareness of nearby COVID-19 testing centers, internet access, knowledge of preexisting conditions and having another member of the family testing positive at 5% significance level.Conclusion: Knowledge of pre-existing conditions, knowledge of COVID-19 symptoms, and knowing where to go when having symptoms were significantly associated with testing and willingness to test.
Coagulopathy in Patients with Severe Burn Injury: A Literature Review
Authors: Скакун П.В. , Жилинский Е.В. , Губичева А.В. , Алексеев С.А. 
Published: October 2022

Термическая травма связана со значительным уровнем заболеваемости и летальности и является одной из недооцененных причин травматизма. Данный вид травматизма имеет значительные социально-экономические последствия, которые затрагивают все социальные группы населения. Тяжелая термическая травма приводит к развитию ожоговой болезни, которая сопровождается нарушением функции различных органов и систем, иммунной и воспалительной реакцией, метаболическими изменениями и распределительным шоком, которые могут привести к полиорганной недостаточности и смерти. Одним из осложнений ожоговой болезни является системная коагулопатия. Развитие коагулопатии у пациентов с ожоговой травмой значительно усложняет и без того высокий уровень интенсивной терапии, необходимый для данной группы пациентов. Четкие руководящие принципы для лечения коагулопатии у пациентов с тяжелыми ожогами на данный момент отсутствуют, поэтому дальнейшее изучение данного феномена является перспективным. В этом обзоре рассмотрены современные патогенетические теории развития коагулопатий, связанных с термической травмой, рассмотрено текущее понимание изменения компонентов системы свертывания, системы фибринолиза и воспалительного ответа в остром и отсроченном периоде ожоговой травмы.
Thermal trauma is associated with a significant level of morbidity and mortality and is one of the underestimated causes of injury. Severe thermal trauma leads to the development of burn disease, which is accompanied by impaired function of various organs and systems, immune and inflammatory reactions, metabolic changes and distributive shock, which can lead to multiple organ failure and death. One of the complications of burn disease is systemic coagulopathy. The development of coagulopathy in patients with burn injury significantly increases the already high level of intensive care required for this group of patients. Clear guidelines for the treatment of coagulopathy in patients with severe burns are currently lacking, therefore further study of this phenomenon is promising. In this review, the current pathogenetic theories of coagulopathies associated with thermal trauma are surveyed, and the current understanding of changes in coagulation system components, the fibrinolysis system, and the inflammatory response in the acute and delayed period of burn injury is examined.
Pembangunan Pariwisata Perbatasan (Border Tourism) Berbasis Pengarusutamaan Gender
Authors: Arieta Siti , Niko Nikodemus , Rahmaniah Syarifah Ema , Rupita Rupita , Igiasi Teguh Setiandika 
Published: October 2022

Pembangunan wilayah perbatasan merupakan pusat perhatian pemerintah baik daerah maupun pusat. Upaya terencana ini bertujuan untuk mengubah wilayah yang dihuni oleh komunitas dengan berbagai permasalahan sosial, ekonomi dan keterbatasan fisik, terutama dalam pemberdayaan perempuan perbatasan. Keterbatasan sumber daya maupun akses wilayah yang dihadapi perempuan menjadikan mereka rentan terhadap kemiskinan, eksploitasi hingga kekerasan dalam rumah tangga. Penelitian ini menggunakan pendekatan kualitatif deskriptif dengan eksplorasi data primer dan sekunder berbasis repositori daring. Pengumpulan data dilakukan dengan studi pustaka tidak terstruktur. Penelusuran daring terhadap data BPS dan menggunakan data kabupten/kecamatan di perbatasan. Berdasarkan pembahasan, temuan studi awal penelitian ini yaitu belum adanya inisiatif pengarusutamaan gender (PUG) pada sektor pembangunan wisata perbatasan di Kalimantan Barat dan Kepulauan Riau. Sehingga keterbatasan perempuan terhadap akses kepariwisataan ditandai dengan rendahnya partisipasi mereka dalam pembangunan. Artinya bahwa pengarusutamaan gender dalam pembangunan masih perlu di evaluasi dalam pembangunan berkelanjutan daerah.
Peran Pendidikan Dan Sumber Informasi Pada Pengetahuan Ibu Tentang Pemberian Makanan Pendamping Air Susu Ibu
Authors: Simatupang Sophia 
Published: October 2022

Makanan pendamping Air Susu Ibu (MPASI) menjadi makanan pelengkap ASI yang diberikan saat bayi berusia 6 bulan. Namun, Penelitian menyatakan bahwa 60% bayi sebelum usia 6 bulan telah mendapatkan MPASI. Salah satu penyebab keadaan tersebut adalah karena pengetahuan ibu yang masih kurang dalam pemberian MPASI. Beberapa penelitian menegaskan bahwa pendidikan dan sumber informasi adalah faktor yang berperan dalam pengetahuan seseorang. Pengetahuan seorang ibu tentang MPASI sangatlah penting untuk mencegah stunting, yang sampai dengan saat ini masih menjadi masalah kesehatan di Indonesia. Penelitian ini bertujuan untuk menganalisis peran pendidikan dan sumber informasi pada pengetahuan ibu tentang pemberian MPASI di Wilayah Kerja PKM Sukatani. Metode penelitian yang digunakan adalah analitik dengan pendekatan secara cross sectional. Sampel yang digunakan adalah ibu yang memiliki bayi usia 6-24 bulan sebanyak 77 responden yang diambil dengan teknik proportional random sampling. Pengambilan data primer menggunakan kuesioner dan dianalisis secara univariat dan bivariat. Hasil penelitian menunjukkan sebanyak 44,2% ibu memiliki pengetahuan yang kurang, 50,6% berpendidikan menengah, 53,2% mendapatkan sumber informasi dari non tenaga kesehatan, ada hubungan antara pendidikan dengan pengetahuan Ibu tentang pemberian MPASI (p value=0,000), ada hubungan antara sumber informasi dengan pengetahuan Ibu tentang pemberian MPASI (p value=0,000). Pendidikan dan sumber informasi berperan dalam menentukan pengetahuan Ibu dalam pemberian MPASI. Disarankan untuk mempersiapkan calon ibu agar meningkatkan pendidikannya dan sumber informasi kesehatan tentang MPASI diberikan oleh tenaga kesehatan.