bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forecasting 100-year changes of streamflow in the Mun River Basin (NE Thailand) under the HAPPI experiment using the SWAT model
Authors: Bridhikitti Arika , Ketuthong Arocha , Prabamroong Thayukorn , Renzhi Li , Jing Li , Gaohuan Liu 
Published: March 2022

Abstract
The Lower Mekong River is one of the significant rivers nurturing people on the Southeast Asian mainland. Its tributaries include the Mun River (NE Thailand), which often experiences extreme water events. In this study, the streamflow change in the year 2115 was simulated by relying on the Half a degree Additional warming, Prognosis and Projected Impacts (HAPPI) experiment and the Model for Interdisciplinary Research on Climate, version 5 (MIROC5) climate model for average global warming of 1.5 °C (Plus1.5) and 2.0 °C (Plus2.0) above pre-industrial levels and compared with the base year in 2015 for the Mun River Basin. The Soil–Water Assessment Tool (SWAT) was used for the streamflow simulation. The results showed an increasing air temperature against lowering rainfall and relative humidity (except for the post-monsoon months), suggesting overall rain suppression in response to the warming climate. The median projected annual streamflow to the Mekong River in 2115 decreased for both ‘Plus1.5’ (−32.5%, median) and ‘Plus2.0’ (−23.1%, median). However, increasing annual streamflow could be found only in the middle part. Seasonal streamflow changes revealed a different spatiotemporal response to climate change resulting in inconsistent streamflow changes across the basin. The adaptive measures for the middle part should be focused on flooding control, whereas the upper and the lower parts should be against drought.
Isolation and identification of potentially pathogenic free-living amoeba in drinking, surface, and stagnant water sources from Alborz Province, Iran
Authors: Javanmard Ehsan , Niyyati Maryam , Taghipour Ali , Fatemi Marziye , Mirjalali Hamed , Karanis Panagiotis 
Published: March 2022

Abstract
Free-living amoebas (FLAs) can cause neurological and ocular complications in humans. Water supplies play a critical role in transmitting FLAs to humans. The aim of the present study was to investigate the presence of FLAs in various aquatic sources including drinking water, stagnant water, and surface water in Alborz province, northern Iran, using morphological and molecular techniques. A total of 70 water samples were collected from 34 drinking waters, 23 surface waters, and 13 stagnant waters. Filtration and cultivation were employed to isolate FLAs. PCR assay was applied by using the genus-specific primers on positive samples. Pathogenicity tests (osmo- and thermo-tolerance properties) were performed for Acanthamoeba spp., positive sample. Considering the morphological criteria, four positive samples of Acanthamoeba sp., three Vermamoeba sp., two mixed Vermamoeba sp. with Vahlkamfiids, and one mixed Acanthamoeba sp. with Vahlkamfiids were isolated. Five Acanthamoeba sp. isolates were amplified using the JDP primer pairs. Among them, two genotypes, T4 (three isolates) and T5 (two isolates) corresponding to A. lenticulata, were identified. Four V. vermiformis samples were confirmed using the sequencing. This study highlighted the occurrence of potentially pathogenic waterborne FLAs in water habitats associated with high human activity. The results of such research on the prevalence of FLAs, as a human hazard, should be communicated to health policymakers.
Vulnerability assessment of water resources in a karst mountainous area based on GIS/RS technology: a case study of Guiyang, Southwest China
Authors: Li Wei , Zhao Zulun , Lv Sisi , Zhao Weiquan , Su Weici 
Published: March 2022

Abstract
Water resource vulnerability in ecologically vulnerable karst areas is a key issue for regional sustainable development and the sustainable use of water resources. In this study, geographical information system (GIS) and remote sensing (RS) technology were employed to explore the vulnerability characteristics and spatial distribution of water resources in Guiyang City. The water resource vulnerability indicator in Guiyang ranged from 0.10 to 0.59, with an average value of 0.26. Yanglongsi Town, in Xifeng County, in the northern and main central urban area exhibited the highest water resource vulnerability, whereas Huaxi District in the south, and regions around Hongfeng Lake and Baihua Lake, in Qingzhen City, exhibited the lowest water resource vulnerability. Water resource vulnerability was predominantly mild, accounting for 35.85% of the total land area, followed by moderate (28.99%), with some non-vulnerable areas (13.60%) and very few extremely vulnerable areas (3.20%). Compared with traditional methods, the proposed index selection and assessment methods, based on GIS/RS, are both scientific and intuitive. In addition, the results are presented in detail, accurately reflecting the actual situation of water resource system vulnerability.
Spatial equilibrium model-based optimization for inter-regional virtual water pattern within grain trade to relieve water stress
Authors: Yao Liming , Tan Shiqi , Hou Shuhua 
Published: March 2022

Abstract
Realizing water usability and management sustainability represents one of the Sustainable Development Goals. Since grain cultivation consumes tremendous amounts of water, the inter-regional grain trade causes virtual water flow, increasing water stress in certain water-scarce regions. As the second-longest river in China, the Yellow River bears increasingly severe water stress. Considering water and food security, this study proposes a spatial equilibrium model (SEM) that combines partial equilibrium theory and transport models to maximize net social revenue and to balance grain supply and demand, thereby optimizing inter-regional grain trade to relieve water stress. According to different natural, technical and social conditions, we conceived five scenarios to predict regional water stress characterized with different water supplies, demographic structures, food demand compositions and water-saving technologies. Our simulation results suggest that the developed SEM can realize spatial equilibrium of food and water resources within the Basin, which is capable of resolving the problem of food demands in regions with varying extents (13%–55%), optimizing inter-regional grain trade and mitigating water stress. Finally, we recommend some constructive policies for different scenarios to relieve water stress.
An essential tool for WRRF modelling: a realistic and complete influent generator for flow rate and water quality based on data-driven methods
Authors: Li Feiyi , Vanrolleghem Peter A. 
Published: March 2022

AbstractModelling, automation, and control are widely used for water resource recovery facility (WRRF) optimization. An influent generator (IG) is a model, aiming to provide the flowrate and pollutant concentration dynamics at the inlet of a WRRF for a range of modelling applications. In this study, a new data-driven IG model is proposed, only using routine data and weather information, and without need for any additional data collection. The model is constructed by an artificial neural network (ANN) and completed with a multivariate regression to generate time series for certain pollutants. The model is able to generate flowrate and quality data (TSS, COD, and nutrients) at different time scales and resolutions (daily or hourly), depending on various user objectives. The model performance is analyzed by a series of statistical criteria. It is shown that the model can generate a very reliable dataset for different model applications.
Going beyond conventional wastewater treatment plants within circular bioeconomy concept – a sustainability assessment study
Authors: Marami Hadis , Tsapekos Panagiotis , Khoshnevisan Benyamin , Madsen Jeanette Agertved , Andersen Jacob Kragh , Rafiee Shahin , Angelidaki Irini 
Published: March 2022

Abstract
Wastewater treatment plants (WWTP) have extensive energy processes that undermine their economic and environmental performance. In this context, the integration of wastewater treatment with other biochemical processes such as co-digestion of sludge with organic wastes, and production of value-added products at their downstream processes will shift conventional WWTPs into biorefinery platforms with better sustainability performance. The sustainability of such a biorefinery platform has been investigated herein using an economic and life cycle assessment approach. This WWTP-based biorefinery treats wastewater from Copenhagen municipality, co-digests the source-sorted organic fraction of municipal solid waste and sludge, and upgrades biogas into biomethane using a hydrogen-assisted upgrading method. Apart from bioenergy, this biorefinery also produces microbial protein (MP) using recovered nutrients from WWTP's reject water. The net environmental savings achieved in two damage categories, i.e., −1.07 × 10−2 species.yr/FU in ecosystem quality and −1.68 × 106 USD/FU in resource scarcity damage categories along with high potential windows for the further environmental profile improvements make this biorefinery platform so encouraging. Despite being promising in terms of environmental performance, the high capital expenditure and low gross profit have undermined the economic performance of the proposed biorefinery. Technological improvements, process optimization, and encouraging incentives/subsidies are still needed to make this platform economically feasible.
Análise epidemiológica nacional de mamoplastias reconstrutivas pós-mastectomia com implante de próteses de 2009 a 2019
Authors: Portela Pereira Victória dos Reis , Moreira Lara Thaís , Baptiste de Paula Sara , Almeida Adorno Iara , Ferreira de Azevedo Mariana Luíza , Martins de Oliveira Maia Lucineide 
Published: March 2022

O câncer de mama é a neoplasia maligna feminina mais incidente no Brasil, a qual tem como opção terapêutica a mastectomia. Assim como o diagnóstico, o tratamento da neoplasia desencadeia distúrbios físicos e emocionais nas pacientes, o que poderia ser minimizado pela reconstrução mamária, podendo ser feita com implante de próteses. O objetivo do estudo foi analisar a epidemiologia nacional nos últimos 10 anos das mamoplastias reconstrutivas pós-mastectomia com implante de próteses. Para tal fez-se uma coleta de dados do DATASUS, de janeiro de 2009 a dezembro de 2019, analisando número de internações, distribuição geográfica, número de óbitos, tempo médio de internação, caráter de atendimento, complexidade, valores total e médio de internação. No período analisado, houve 15.775 procedimentos, sendo eles liderados pela região Sudeste (9.698), enquanto a região Norte apresentou o menor número de internações (280). A maioria apresentou caráter eletivo (85,12%), todos foram considerados de média complexidade, sendo obtidos resultados de 3 óbitos. A média de permanência hospitalar nacional foi de 2,0 dias e os valores total e médio foram, respectivamente R$ 14.176.879,60 e R$ 898,69. Desta forma, conclui-se que a região Sudeste apresenta o maior número de procedimentos e gastos, o que pode ser explicado pela sua concentração de especialistas e recursos. Ademais, é de suma importância destacar como a reconstrução mamária melhora a qualidade de vida das pacientes e, apesar disso, não é amplamente realizada no território brasileiro.
Palavras-chave: Mastectomia; Mamoplastia; Epidemiologia; Implantes de Mama.
Evolução da doença hepática gordurosa não alcoólica: revisão de literatura
Authors: Miquelito Juliana , Conceição Siqueira Emílio 
Published: March 2022

A doença hepática gordurosa não alcoólica (DHGNA) é uma das mais frequentes causas de doença hepática, acometendo todas as faixas etárias e ambos os sexos. É considerada a hepatopatia crônica mais comum nos países ocidentais e é definida como o acúmulo excessivo de lipídeos no citoplasma dos hepatócitos, excedendo 5% do peso do órgão. Ademais, é uma condição patológica de amplo espectro e com elevada capacidade evolutiva, que inclui a esteatose hepática e a esteato hepatite, a qual pode evoluir para cirrose e carcinoma hepatocelular (CHC). Contudo, essa evolução não segue um padrão, visto que há uma elevação no desenvolvimento de CHC em pacientes com esteato hepatite que não avançaram para cirrose. O presente trabalho objetivou expor e correlacionar dados epidemiológicos e informações sobre a evolução da esteato hepatite, visto que a DHGNA pode ser prevenida ou minimizada, desde que seja diagnosticada precocemente e esteja associada a mudanças no estilo de vida. A metodologia fundamentou-se na pesquisa de artigos científicos nacionais e internacionais usando como base o Pubmed. Foram incluídos artigos originais indexados entre os anos de 2010 e 2020. Os dados analisados comprovam que dos pacientes com esteato hepatite acompanhados por até 9 anos, 27% progrediram para fibrose e 19% para cirrose, enquanto isso a maioria dos pacientes apenas com esteatose permaneceram sem lesão hepática mesmo com acompanhamento de até 20 anos. Portanto, conclui-se que o presente estudo se faz de grande destaque, visto que trata de um tema com expressiva prevalência e associa-se a diversas comorbidades.
Palavras - chave: Esteatose hepática; Esteato hepatite; Cirrose; Carcinoma hepatocelular.
Rim em ferradura em peça cadavérica e sua correlação clínica e cirúrgica: Relato de caso
Authors: Grillo de Freitas Karine , Emílio Conceição de Siqueira Emílio 
Published: March 2022

O rim em ferradura consiste na má formação congênita de fusão renal de maior frequência, com ocorrência média de 0,25%da população, sendo duas vezes mais frequente no sexo masculino. Ademais, cursa com numerosas variações anatômicas associadas, principalmente no que tange a sua vascularização. Foi realizado um estudo de trabalhos nacionais e internacionais, visando identificar casos clínicos descritos sobre a condição estudada e correlacioná-los com a macroscopia da peça cadavérica exposta. O estudo visa relatar o achado de um Rim em Ferradura no Instituto de Anatomia da Universidade de Vassouras e correlacioná-lo com a clínica, objetivando atualizar profissionais e estudantes da área médica quanto à suas repercussões clínicas e cirúrgicas. Foi avaliado um Rim em Ferradura que possui medidas de 28cm de comprimento total (40% acima do normal), 5 cm de largura e 2,5 cm de espessura, ambas consideras dentro do padrão de normalidade. O hilo renal está situado mais anteriormente que o normal e foi identificadas duplicação e dilatação das veias renais de cada lado. Observou-se também a compressão da artéria aorta abdominal e da veia cava inferior, posteriormente ao local de fusão dos rins. Além disso, há expressiva impressão da artéria mesentérica inferior sobre o parênquima renal que limitou a ascensão do órgão. Portanto, variações renais podem expressar uma influência significativa na predisposição a enfermidades, curso da doença, alterações nos exames clínicos e em exames complementares. Portanto, os cirurgiões e clínicos que possuem conhecimento prévio da anomalia podem minimizar iatrogenias cirúrgicas e minimizar sintomas.
Palavras- chave: Rim em ferradura; Aorta abdominal; Tumor de wilms.
Research Progress of Quercetin Delivery Systems
Authors: Zhao Xingtao , Deng Ying , Xue Xinyan , Liao Li , Zhou Mengting , Peng Cheng , Li Yunxia 
Published: March 2022

Abstract:Quercetin is the main dietary flavonoid with a wide range of pharmacological activities. However, the poor gastrointestinal absorption and low bioavailability of quercetin curtails its clinical applications.. Enhancement the bioavailability of quercetin focuses on the application of delivery systems technologies such as microparticle delivery systems, solid dispersions, encapsulation, phospholipid complexes, and hydrogels , which have been systematically reviewed .And theirapplications in vitro and in vivo animal experiments also been described, promoting the development and optimization of drug delivery system for clinical applications.
Current Treatment and Future Trends of Immunotherapy in Breast
Cancer
Authors: Cescon David W. , Elliott Mitchell J. , Wilson Brooke 
Published: March 2022

Abstract:
Immunotherapy continues to redefine the solid tumor treatment landscape, with inhibitors of
the PD-L1/PD-1 immune checkpoint having the most widespread impact. As the most common cancer
diagnosed worldwide, there is significant interest in the development of immunotherapy for the treatment
of breast cancer in both the early and metastatic settings. Recently reported results of several clinical
trials have identified potential roles for immunotherapy agents alone or in combination with standard
treatment for early and metastatic disease. While trials to date have been promising, immunotherapy
has only been shown to benefit a select group of patients with breast cancer, defined by tumor subtype,
PD-L1 expression, and line of therapy. With over 250 trials ongoing, emerging data will enable
the further refinement of breast cancer immunotherapy strategies. The integration of multiple putative
biomarkers and consideration of dynamic markers of early response or resistance may inform optimal
patient selection for immunotherapy investigation and integration into clinical practice. This review
will summarize the current evidence for immune-checkpoint blockade (ICB) in the treatment of early
and metastatic breast cancer, highlighting current and potential future biomarkers of therapeutic response.
Clinical Outcomes of Zinc Supplementation Among COVID-19 Patients
Authors: Giuliano Christopher A. , Berti Andrew D. , Kale-Pradhan Pramodini B. , Aprilliano Bianca N. , Miller Christopher R. , Alyashae Basma T. , Bhargava Ashish , Johnson Leonard B. 
Published: March 2022

Background:
Zinc supplementation is frequently prescribed during the treatment of
COVID-19. However, the evidence supporting the efficacy of this intervention is mixed.

Objective:
Establish the clinical utility of zinc supplementation to alter disease severity in COVID-
19 illness.

Methods:
We performed a multicenter, retrospective, observational chart review of patients
admitted to Ascension St. John Hospital or Detroit Medical Center from January 1st, 2020 to May
31st, 2020. All included patients received concomitant hydroxychloroquine due to its zinc
ionophore activity. Our primary outcome was a change in Sequential Organ Failure Assessment
(SOFA) score with secondary outcomes including all-cause mortality, need for intubation, and QTc
prolongation as a safety outcome.

Results:
We identified 489 patients who received zinc and 587 patients who did not. The primary
outcome showed a small difference in the change in SOFA score in patients receiving zinc in
univariate analysis (1.08 vs. 1.43, p=0.02), but this difference was not significant after adjustment
for confounding factors such as receipt of corticosteroids and ICU admission. Mortality was not
different between those that received zinc compared to those that did not (32.7% vs. 35.9%,
p=0.268).

Conclusion:
Our retrospective study, including 1064 patients hospitalized in Detroit, demonstrated
no differences in mortality or disease severity with zinc combination. Furthermore, prospective
studies are needed to establish the utility of zinc in the treatment of COVID-19.
Design, Synthesis, and Pharmacological Evaluation of Substituted
Oxadiazole-Pyridazin-3-One Derivatives as Antioxidant and
Antimicrobial Agents
Authors: Saini Minaxi , Das Rina , Mehta Dinesh K. 
Published: March 2022

Background:
The chemical modification of pyridazinone leads to a potent therapeutic
agent.

Aim:
A series of novel analogues of 4,5-dichloro-6-(substituted-benzyl)-2-(5-mercapto-[1,3,4]-
oxadiazol-2-ylmethyl)-2H-pyridazin-3-one have been synthesized.

Objectives:
The novel synthesized pyridazinone derivatives were docked for possible targets,
followed by antimicrobial and antioxidant activities.

Methods:
The target compounds were synthesized using a nucleophilic substitution reaction. The
structures of newly synthesized compounds were confirmed by FT-IR, 1H-NMR, 13C-NMR,
mass spectroscopy, and elemental analysis.

Results:
The novel synthesised compounds were screened for their antimicrobial and antioxidant
properties in vitro. Compound 5e showed good antibacterial and antifungal activity with MIC 25
μg/mL and 6.25 μg/mL against all the bacterial and fungal strains and in-vitro antioxidant
activity with an IC50 of 51.64. The experimental results were further supported by molecular
docking analysis using V-Life Science MDS 4.6 software and the GRIP batch docking method.

Conclusion:
All the compounds have been evaluated in vitro for antioxidant and antimicrobial
activities against several strains of microbes and have shown significant activity. The
experimental results were further supported by molecular docking analysis, describing improved
interaction patterns.
Development of a Maternal and Child mHealth Intervention With Aboriginal and Torres Strait Islander Mothers: Co-design Approach
Authors: Perkes Sarah Jane , Huntriss Belinda , Skinner Noelene , Leece Bernise , Dobson Rosie , Mattes Joerg , Hall Kerry , Bonevski Billie 
Published: March 2022

Background
Despite their growing popularity, there are very few mobile health (mHealth) interventions for Aboriginal and Torres Strait Islander people that are culturally safe and evidence based. A co-design approach is considered a suitable methodology for developing health interventions with Aboriginal and Torres Strait Islander people.

Objective
The aim of this study was to co-design an mHealth intervention to improve health knowledge, health behaviors, and access to health services for women caring for young Aboriginal and Torres Strait Islander children.

Methods
Aboriginal researchers led engagement and recruitment with health services and participants in 3 Aboriginal and Torres Strait Islander communities in New South Wales, Australia. Focus groups and interviews were facilitated by researchers and an app developer to gather information on 3 predetermined themes: design characteristics, content modules, and features and functions. Findings from the co-design led to the development of an intervention prototype. Theories of health behavior change were used to underpin intervention components. Existing publicly available evidence-based information was used to develop content. Governance was provided by an Aboriginal advisory group.

Results
In total, 31 mothers and 11 health professionals participated in 8 co-design focus groups and 12 interviews from June 2019 to September 2019. The 6 design characteristics identified as important were credibility, Aboriginal and Torres Strait Islander designs and cultural safety, family centeredness, supportive, simple to use, and confidential. The content includes 6 modules for women’s health: Smoke-free families, Safe drinking, Feeling good, Women’s business, Eating, and Exercising. The content also includes 6 modules for children’s health: Breathing well; Sleeping; Milestones; Feeding and eating; Vaccinations and medicines; and Ears, eyes, and teeth. In addition, 6 technology features and functions were identified: content feed, social connection, reminders, rewards, communication with health professionals, and use of videos.

Conclusions
An mHealth intervention that included app, Facebook page, and SMS text messaging modalities was developed based on the co-design findings. The intervention incorporates health behavior change theory, evidence-based information, and the preferences of Aboriginal and Torres Strait Islander women and health professionals. A pilot study is now needed to assess the acceptability and feasibility of the intervention.