bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimal invasiveness in the transcrestal elevation of the maxillary sinus floor: A systematic review
Authors: Farina Roberto , Franzini Chiara , Trombelli Leonardo , Simonelli Anna 
Published: August 2022

AbstractIn the attempt to reduce the invasiveness of a transcrestal sinus floor elevation procedure, different aspects must be considered; that is, the minimization of intra‑ and postsurgery morbidity, the reduction of treatment time, and the simplification/elimination of the reconstructive technology. Within this context, a systematic literature search was performed for controlled clinical trials evaluating the impact of one or more of these aspects on transcrestal sinus floor elevation invasiveness. Nineteen articles (15 studies) were included. Overall, the results confirmed that transcrestal sinus floor elevation is a minimally invasive and effective option for bone augmentation in the edentulous, atrophic posterior maxilla. By using powered instruments rather than manual osteotomes and hand mallet, the invasiveness of transcrestal sinus floor elevation can be further reduced without affecting its clinical effectiveness. To impact effectively on morbidity, the key elements to consider when selecting instruments for transcrestal sinus floor elevation are (a) their availability as a standardized sequence, to be adapted on predetermined residual bone height, and (b) the possibility to control pressure (eg, with screwable osteotomes) and/or instrument excursion (eg, with stop devices) to fracture the maxillary sinus floor. Among powered instruments, a standardized sequence of drills incorporating a trephine drill seem to be particularly indicated, due to reduced chair time, high tolerability for the patient, and the possibility to isolate a bone core to implement histomorphometric outcomes. At molar extraction sites with an interradicular septum characterized by a height of at least 4 mm, immediate transcrestal sinus floor elevation and implant placement can be considered a valid option to shorten treatment time.
Oral alterations in children with microcephaly associated to congenital Zika syndrome: A systematic review and meta‐analyses
Authors: Silva Leni Verônica de Oliveira , Hermont Ana Paula , Magnani Isabela Queiroz , Martins Carolina Castro , Borges‐Oliveira Ana Cristina 
Published: August 2022

AbstractAIMSTo synthesize the oral alterations observed in children with microcephaly associated with congenital Zika virus syndrome (CZS), and to compare the oral alterations of these children to a normotypic healthy controls.METHODS AND RESULTSA search was performed in six electronic databases. Observational studies published that reported oral alterations in children with CZS were selected. Two authors independently extracted data, assessed study quality, using the Joanna Briggs Institute Critical Appraisal Checklist tools, and the certainty of evidence, using Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Twenty‐one studies were included in this systematic review and meta‐analysis. The pooled crude occurrence showed 88% of increased salivation (95%CI: 82%–94%), 83% of biofilm (95%CI: 75%–91%), and 73% of bruxism (95%CI: 52%–95%). Compared to normotypic controls, children with CZS‐associated microcephaly had a higher chance to have difficulty in lip sealing (OR: 18.28; 95%CI: 1.42–235.91), inadequate lingual posture at rest (OR: 13.57; 95%CI: 4.24–43.44), and delayed eruption (OR: 12.92; 95%CI: 3.42–48.78), with very low certainty.CONCLUSIONThere are several oral alterations found among children with CZS‐associated microcephaly. They are more prone to present some of these alterations, such as difficulty in lip sealing, although with very low certainty of evidence.
Spectral transmittance of animal intraocular lenses in comparison with the spectral properties of their biological lenses
Authors: Giannikaki Stamatina , Douglas Ronald H. 
Published: August 2022

AbstractPurposeTo determine the spectral transmittance of artificial intraocular lenses (IOLs) designed for various species (dog, cat, chinchilla, eagle, tiger) and compare them to the spectral properties of the biological lenses of these species.MethodsTwenty‐seven IOLs were scanned with a spectrophotometer fitted with an integrating sphere.ResultsAll IOLs transmitted long wavelengths well before cutting off sharply at short wavelengths, with insignificant transmission below ca. 340 nm. In comparison with the IOLs, the biological lenses of the cat, dog, and probably the chinchilla transmitted significantly more short wavelengths. The spectral properties of the biological lenses of eagles and tigers, while uncertain, may be a closer match to the IOLs made for these species.ConclusionIt is not known if there are any visual or behavioral consequences for animals caused by a mismatch between the spectral properties of their biological lenses and IOLs. However, following IOL implantation there might be a change in the perceived hue of objects due to the removal of UV wavelengths which form a normal part of the visible spectrum for these species and/or a decrease in sensitivity.
Effect of adrenaline on serum mid‐regional pro‐atrial natriuretic peptide and central blood volume
Authors: Sejersen Casper , Bjerre‐Bastos Jonathan J. , Goetze Jens P. , Nielsen Henning B. , Bihlet Asger R. , Secher Niels H. 
Published: August 2022

New Findings
What is the central question in this study?
Atrial natriuretic peptide (ANP) is secreted in response to atrial wall distension and thus allows for evaluation, albeit indirect, of the central blood volume. Adrenaline has chronotropic and inotropic effects. We evaluated whether the chronotropic and inotropic effects of adrenaline were reflected in mid‐regional proANP.

What is the main finding and its importance?
Central blood volume remained stable with infusion of adrenaline and yet mid‐regional proANP increased. Thus, the chronotropic and inotropic state of the heart or adrenaline directly induces release of ANP variants from the myocytes.

AbstractAtrial natriuretic peptide (ANP) has vasodilatory, natriuretic and diuretic properties. It is secreted in response to atrial wall distension and thereby provides an indirect evaluation of central blood volume (CBV). Adrenaline has chronotropic and inotropic effects that increase cardiac output. In the present study, we evaluated whether these effects were influenced by an increase in CBV and reflected in mid‐regional proANP (MR‐proANP) concentrations in the circulation, a stable proxy marker of bioactive ANP. Changes in CBV were evaluated by thoracic electrical admittance and haemodynamic variables monitored by pulse‐contour analysis during two intervals with graded infusion of adrenaline. Adrenaline infusion increased heart rate (by 33 ± 18%) and stroke volume (by 6 ± 13%), hence cardiac output (by 42 ± 23%; all P < 0.05). The increase in cardiac output did not result from an increase in CBV, because thoracic electrical admittance remained stable (−3 ± 17%; P = 0.230). Serum MR‐proANP concentrations were increased (by 26 ± 25%; P < 0.001) by adrenaline infusion and remained elevated 60 min postinfusion. We conclude that MR‐proANP in the circulation is affected not only by CBV, but also by increased chronotropy/inotropy of the heart, or that adrenaline directly induces release of ANP variants from the myocytes.
A Rattle Noise Severity Index for Multi-Mesh Gear Trains Subjected to Torque Fluctuations
Authors: Donmez Ata , Kahraman Ahmet 
Published: August 2022

AbstractExternal fluctuation torques acting on gear trains having clearances often cause vibro-impact motions with resultant rattle noise issues. In this study, an impact velocity-based rattle severity parameter that correlates with the resultant rattling noise is proposed for multimesh gear trains. An experimental setup is employed to measure torsional vibro-impact motions and the corresponding sound pressure levels of a three-axis gear train under various torque fluctuation conditions. A discrete torsional model of the experimental setup is developed and validated through comparisons to the vibration measurements. An impact velocity-based rattle severity index defined from the predicted response is proposed and shown to correlate well with the measured rattle noise sound pressure levels within a wide range of operating conditions. The demonstrated ability of the proposed rattle severity index in tracking rattle noise allows for the assessment of rattle consequences of a multimesh drivetrain solely from its predicted torsional response.
Impact of a prescriber and patient educational intervention on discharge analgesia prescribing and hospital readmission rates following elective unilateral total hip and knee arthroplasty
Authors: Wood Daniel , Moy Shuh Fen , Zhang Shiran , Lightfoot Nicholas 
Published: August 2022

IntroductionPain management after elective, unilateral total hip and knee arthroplasty (THA and TKA) should use a multimodal approach. At discharge, challenges include ensuring correct prescribing practices to optimise analgesia and rationalise opioid use as well as ensuring patients are adequately educated to take these medications safely and effectively in the community. This audit cycle reports on a prescriber and patient education intervention using printed guidelines, educational outreach and prescription standardisation along with a patient information sheet to address the high unplanned readmission rate following THA and TKA at our institution.MethodsTwo cohorts of patients were identified before (2016) and after (2019) the introduction of the educational package. The primary outcome was the unplanned hospital readmission rate in the 42 days following discharge. Secondary outcomes were the compliance with the set prescribing standards and the prescription of strong opioid medications (morphine or oxycodone) on discharge.ResultsThere was a reduction in the readmission rate from 20.4% to 10.0% (p=0.004). Readmission rates for pain and constipation were also reduced. The prescribing of tramadol (p<0.001) and non-steroidal anti-inflammatory drugs (p<0.001) both increased while the number of patients who received a strong opioid at discharge decreased (p<0.001) as did the number of patients who received a sustained release strong opioid (p<0.001).ConclusionWe have observed significant improvement in discharge prescribing which coincided with a reduction in unplanned readmissions after elective TKA and THA. Our approach used prescriber guidelines, education and standardisation with printed information for patients to enhance understanding and recall.
Patient and healthcare team recommended medication adherence strategies for hydroxychloroquine: results of a qualitative study informing intervention development
Authors: Garg Shivani , Chewning Betty , Gazeley David , Gomez Shelby , Kaitz Noah , Weber Amanda C , Rosenthal Ann , Bartels Christie 
Published: August 2022

ObjectivePatients identified as black and from disadvantaged backgrounds have a twofold higher hydroxychloroquine (HCQ) non-adherence, which contributes to worse lupus outcomes and disparities. Yet, most adherence interventions lack tailored strategies for racially and socioeconomically diverse patients who face unique challenges with HCQ. We aimed to examine a broadly representative group of patients with SLE and physician perspectives on HCQ adherence and adherence strategies to redesign an adherence intervention.MethodsWe conducted four virtual focus groups (90 min each) with 11 racially and socioeconomically diverse patients with SLE recruited from two health systems. Additionally, we hosted two focus group meetings with nine healthcare advisors. In focus groups, patients: (1) shared their perspectives on using HCQ; (2) shared concerns leading to non-adherence; (3) discussed strategies to overcome concerns; (4) prioritised strategies from the most to least valuable to inform an adherence intervention. In two separate focus groups, healthcare advisors gave feedback to optimise an adherence intervention. Using content analysis, we analysed transcripts to redesign our adherence intervention.ResultsWorry about side effects was the most common barrier phrase mentioned by patients. Key themes among patients’ concerns about HCQ included: information gaps, logistical barriers, misbeliefs and medication burden. Finally, patients suggested adherence strategies and ranked those most valuable including co-pay assistance, personal reminders, etc. Patient and healthcare advisors informed designing a laminate version of an adherence intervention to link each barrier category with four to six patient-recommended adherence strategies.ConclusionWe developed a patient stakeholder-informed and healthcare stakeholder-informed tailored intervention that will target non-adherence at the individual patient level.
A Semantic Web-Enabled Approach for Dependency Management
Authors: Eghan Ellis E. , Rilling Juergen 
Published: August 2022

The use of external libraries in today’s software projects allows developers to take advantage of features provided by such application programming interfaces (APIs) without having to reinvent the wheel. However, APIs have also introduced new challenges to the software engineering community (e.g. API incompatibilities, software vulnerabilities, and license violations) that extend beyond traditional project boundaries and often involve different software artifacts. One potential solution to these challenges is to provide a technology-independent representation of software dependency semantics and its integration with knowledge from other software artifacts. In our research, we take advantage of the semantic web (SW) and its technology stack to establish a unified knowledge representation of build and dependency repositories. Given this knowledge base, we can now extend and integrate other (heterogeneous) resources to allow for a flexible and comprehensive global impact analysis approach. To illustrate the applicability of our SW-enabled modeling approach, we discuss two different applications. These applications illustrate how our modeling approach can not only integrate and reuse knowledge from dependency management systems and other software artifacts, but also take advantage of inference services provided by the SW to support novel software analytics services across artifact and project boundaries.
Chrono-contextual issues at open-air Pleistocene vertebrate fossil sites of central and peninsular India and implications for Indian palaeoanthropology
Authors: Chauhan Parth R. 
Published: August 2022

Abstract
Pleistocene vertebrate fossils are prominently known from several regions across the Indian Subcontinent including the Siwalik Hills, the numerous river valleys across India and some cave sites. Unfortunately, most of this evidence is lacking a robust chronological framework and very few fossil specimens have been subjected to absolute dating methods. All of the known fossil evidence is found in diverse sedimentary contexts and these faunal assemblages have mostly been assigned broad or relative age brackets such as Early Pleistocene (i.e. the Pinjore Formation of the Upper Siwalik Subgroup) and Late Pleistocene (almost all the remaining fossil vertebrate fauna in the rest of the Subcontinent). This paper discusses contextual and chronological perspectives and associated interpretative issues of open-air Pleistocene faunal sites south of the Siwalik Hills, such as north-central and peninsular India. For instance, the virtual lack of Early and Middle Pleistocene fauna across most of India requires consideration and explanations beyond just the lack of absolute dates. A general review of the known data demonstrates a critical need for absolute dates for the various fauna as well as more rigorous field and lab methods for Indian palaeontology in general, and to avoid erroneous implications for Indian palaeoanthropology.
Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer
Authors: Chen Owen J. , Castellsagué Ester , Moustafa-Kamal Mohamed , Nadaf Javad , Rivera Barbara , Fahiminiya Somayyeh , Wang Yilin , Gamache Isabelle , Pacifico Caterina , Jiang Lai , Carrot-Zhang Jian , Witkowski Leora , Berghuis Albert M. , Schönberger Stefan , Schneider Dominik , Hillmer Morten , Bens Susanne , Siebert Reiner , Stewart Colin J.R. , Zhang Ziguo , Chao William C.H. , Greenwood Celia M.T. , Barford David , Tischkowitz Marc , Majewski Jacek , Foulkes William D. , Teodoro Jose G. 
Published: August 2022

Abstract

CDC20 is a coactivator of the anaphase promoting complex/cyclosome (APC/C) and is essential for mitotic progression. APC/CCDC20 is inhibited by the spindle assembly checkpoint (SAC), which prevents premature separation of sister chromatids and aneuploidy in daughter cells. Although overexpression of CDC20 is common in many cancers, oncogenic mutations have never been identified in humans. Using whole-exome sequencing, we identified heterozygous missense CDC20 variants (L151R and N331K) that segregate with ovarian germ cell tumors in two families. Functional characterization showed these mutants retain APC/C activation activity but have impaired binding to BUBR1, a component of the SAC. Expression of L151R and N331K variants promoted mitotic slippage in HeLa cells and primary skin fibroblasts derived from carriers. Generation of mice carrying the N331K variant using CRISPR-Cas9 showed that, although homozygous N331K mice were nonviable, heterozygotes displayed accelerated oncogenicity of Myc-driven cancers. These findings highlight an unappreciated role for CDC20 variants as tumor-promoting genes.

Significance:
Two germline CDC20 missense variants that segregate with cancer in two families compromise the spindle assembly checkpoint and lead to aberrant mitotic progression, which could predispose cells to transformation.
See related commentary by Villarroya-Beltri and Malumbres, p. 3432
Circ_0001821 Affects Proliferation and the Cell Cycle in Esophageal Squamous Cell Carcinoma by Elevating BTRC-Mediated IKBA Ubiquitination
Authors: Lin Changjin , Wei Yujun , Duan Xinchun , Liu Chunquan , Du Yanlin , Wang Xiaoran , Luo Yi , Cui Yong 
Published: August 2022

Abstract

Esophageal squamous cell carcinoma (ESCC) is a fatal human cancer featured with a tendency to metastasis and relapse. Increasing studies have emphasized the critical roles of circular RNAs (circRNA) in ESCC. This study targeted at a novel circRNA and uncovering its function and mechanisms in ESCC. Functional assays were implemented to evaluate proliferation and cell cycle of ESCC cells. Mechanistic analyses were conducted to explore the potential molecular mechanisms in ESCC cells. In vivo assay was also performed. Based on the collected data, circ_0001821 was highly expressed in ESCC cells. Circ_0001821 knockdown retarded ESCC cell proliferation and tumor growth, while promoting G2–M cell cycle arrest. With regard to its mechanism, RUNX3 promoted PVT1 transcription, further upregulating circ_0001821. Moreover, circ_0001821 sponged miR-423–5p to upregulate BTRC, thus promoting IKBA ubiquitination, and circ_0001821 decreased IKBA expression to activate NF-κB signaling pathway. Rescue assays demonstrated that circ_0001821 facilitated ESCC cell proliferation and cell cycle by downregulating IKBA. In summary, RUNX3-induced circ_0001821 switches on NF-κB signaling pathway via diminishing IKBA expression, functionally prompting ESCC cell proliferation and cell cycle.

Implications:
This study uncovered a novel molecular pathway in ESCC progression, which might provide potential biomarkers for ESCC diagnosis.
Minimum Description Length Recurrent Neural Networks
Authors: Lan Nur , Geyer Michal , Chemla Emmanuel , Katzir Roni 
Published: August 2022

Abstract
We train neural networks to optimize a Minimum Description Length score, that is, to balance between the complexity of the network and its accuracy at a task. We show that networks optimizing this objective function master tasks involving memory challenges and go beyond context-free languages. These learners master languages such as anbn, anbncn, anb2n, anbmcn +m, and they perform addition. Moreover, they often do so with 100% accuracy. The networks are small, and their inner workings are transparent. We thus provide formal proofs that their perfect accuracy holds not only on a given test set, but for any input sequence. To our knowledge, no other connectionist model has been shown to capture the underlying grammars for these languages in full generality.
Is There No Sense of Shame among Evangélicos? The Idolatry of Bolsonaro and the Constraints of the Gospel
Authors: von Sinner Rudolf 
Published: August 2022

Abstract
The growing political influence of evangélico Christians in traditionally Catholic Brazil has caught the attention of social and political scientists as well as theologians. What are the reasons for two thirds of the mainly Pentecostal and Neo-Pentecostal electorate voting for Jair Messias Bolsonaro, the representative of an extreme right? This article explores traditional positions aligned with Bolsonaro’s morality, but also those that are contrary. The government’s blatant failure to cope with the COVID-19 pandemic has given, and indeed should give, rise to what the author calls an “evangélico sense of shame” as a consequence of the incompatibility of many of that part of the electorate that explicitly identified its faith convictions with Bolsonaro’s stances and actions. At the extreme end of an uncritical adherence is idolatry, visible, in the president being anointed by Edir Macedo, the supreme bishop of the Universal Church of God’s Kingdom. A genuinely theological dialogue and criticism is needed that would evaluate not only cognitive, but also affective and spiritual arguments and aspects.
Religious Symbols in Public Spaces in Brazil: Controversies and Propositions
Authors: Gabatz Celso 
Published: August 2022

Abstract
This article outlines issues pertinent to the valuation of religions in the Brazilian legal, social and cultural framework, particularly in its Catholic expression. It is a valorisation demonstrated in the form of approximations, contacts and compromises between instances of the state and the religious organizations. The hypothesis is that, within the current picture of religious diversity in its relation to secularity, the great challenge is not mainly in the presence of religion in public spaces, but in monopolies and privileges with an exclusivist character engendered by certain religious groups. The object of research in this approach is, therefore, the incidence of religious symbols present in Brazilian public spaces, their relevance and developments in the perspective of secularity, mainly for the field of sciences of religions, humanities, theology and law.