bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tree vegetative and generative properties and their inter-correlations for prospective apple cultivars under two training systems for young trees
Authors: Csihon Ádám , Gonda István , Szabó Szilárd , Holb Imre J. 
Published: January 2022

AbstractLittle information is available on vegetative and generative performance of apple cultivars during the early growth of trees in orchards. The aim of this five-year study was to evaluate 2 vegetative (trunk cross sectional area (TCSA) and tree height (TH)) and 7 generative parameters (tree yield (TY), fruit number per tree (FNT), crop load (CL), fruit diameter (FD), shape index (SI), fruit surface color (FSC) and fruit color intensity (FCI)) and their inter-correlations (Pearson correlation, regression analyses and PCA) for young apple trees, on 9 apple cultivars (‘Jugala’, ‘Galaval’, ‘Gala Venus Fengal’, ‘Gala Decarli-Fendeca’, ‘Gala Schnitzer (S) Schniga’, ‘Fuji September Wonder’, ‘Crimson Crisp (Co-op 39)’, ‘Jeromine’, and ‘Red Idared’) in a slender spindle training system (2597 trees ha−1) and on 4 apple cultivars (‘Wilton’s Red Jonaprince’, ‘Red Cap Valtod (S)’, ‘Early Red One’, and ‘Red Topaz’) in a super spindle training system (5194 trees ha−1) in Eastern Hungary. The strongest vegetative growth was observed in ‘Red Idared’, while the weakest was in ‘Early Red One’. Most ‘Gala’ mutants showed high yields in all years, except for ‘Galaval’. On the 6 year-old trees, the lowest tree yield was found in ‘Fuji September Wonder’ (8.2 kg tree−1), while the highest was found in ‘Gala Venus Fengal’ (35.8 kg tree−1). The lowest fruit number per tree (15 fruit tree−1) was found in ‘Jeromine’, while the highest (222 fruit tree−1) was in ‘Gala Venus Fengal’. The highest crop load was found in ‘Gala Venus Fengal’ (12.72 fruit per cm2TCSA), while the lowest was in ‘Jeromine’ (2.13 fruit per cm2TCSA). The smallest fruit diameter (66.3 mm) was recorded in ‘Gala Schnitzer (S) Schniga’, while highest (93.6 mm) was in ‘Red Idared’. The lowest shape index (0.73) was found in ‘Red Topaz’, while the highest (0.92) was in ‘Red Idared’. The majority of the cultivars reached very good fruit surface color (80–100%). The lowest fruit surface color (40%) was observed in ‘Gala Schnitzer (S) Schniga’, while the highest (100%) was in ‘Jeromine’ and ‘Early Red One’. The highest fruit color intensity was observed in most cultivars with the exception of ‘Jeromine’, ‘Gala Schnitzer (S) Schniga’ and’Fuji September Wonder’. In addition, correlation and regression analyses revealed strong and significant (p = 0.05) relationships between THvsTCSA, TYvsTCSA, THvsTY, TYvsFNT, and FCIvsFSC. PCA explained 87% of the total variance and PC1, PC2, PC3, and PC4 accounted for 33, 21, 20, and 13% of the variance, respectively, and correlated with TSCA, TH, TY and FNT; with FNT, CL and FS; with FSC and FCI; and with TH and SI, respectively. In conclusion, our study provides useful tree property data on prospective mutants/cultivars for growers/advisors in order to select the most suitable cultivars for establishing new orchards under climate conditions similar to central Europe.
Ethnic disparities in mortality among overweight or obese adults with newly diagnosed type 2 diabetes: a population-based cohort study
Authors: Iyen B. , Vinogradova Y. , Akyea R. K. , Weng S. , Qureshi N. , Kai J. 
Published: January 2022

Abstract
Purpose
Ethnic variation in risk of type 2 diabetes is well established, but its impact on mortality is less well understood. This study investigated the risk of all-cause and cardiovascular mortality associated with newly diagnosed type 2 diabetes in White, Asian and Black adults who were overweight or obese.

Methods
This population-based cohort study used primary care records from the UK Clinical Practice Research Datalink, linked with secondary care and death registry records. A total of 193,528 obese or overweight adults (BMI of 25 or greater), with ethnicity records and no pre-existing type 2 diabetes were identified between 01 January 1995 and 20 April 2018. Multivariable Cox proportional hazards regression estimated hazards ratios (HR) for incident type 2 diabetes in different ethnic groups. Adjusted hazards ratios for all-cause and cardiovascular mortality were determined in individuals with newly diagnosed type 2 diabetes.

Results
During follow-up (median 9.8 years), the overall incidence rate of type 2 diabetes (per 1,000 person-years) was 20.10 (95% CI 19.90–20.30). Compared to Whites, type 2 diabetes risk was 2.2-fold higher in Asians (HR 2.19 (2.07–2.32)) and 30% higher in Blacks (HR 1.34 (1.23–1.46)). In individuals with newly diagnosed type 2 diabetes, the rates (per 1,000 person-years) of all-cause mortality and cardiovascular mortality were 24.34 (23.73–24.92) and 4.78 (4.51–5.06), respectively. Adjusted hazards ratios for mortality were significantly lower in Asians (HR 0.70 (0.55–0.90)) and Blacks (HR 0.71 (0.51–0.98)) compared to Whites, and these differences in mortality risk were not explained by differences in severity of hyperglycaemia.

Conclusions/Interpretation
Type 2 diabetes risk in overweight and obese adults is greater in Asian and Black compared to White ethnic populations, but mortality is significantly higher in the latter. Greater attention to optimising screening, disease and risk management appropriate to all communities with type 2 diabetes is needed.
Long-term benefits of targeted micronutrition with the holoBLG lozenge in house dust mite allergic patients
Authors: Bergmann Karl-Christian , Raab Jennifer , Krause Linda , Becker Sylvia , Kugler Sebastian , Zuberbier Torsten , Roth-Walter Franziska , Jensen-Jarolim Erika , Kramer Matthias F. , Graessel Anke 
Published: January 2022

Summary
Purpose
The long-term effects of targeted micronutrition with the holoBLG lozenge in house dust mite (HDM) allergic rhinoconjunctivitis (ARC) patients were evaluated at a follow-up visit in an allergen exposure chamber (AEC).

Methods
Patients who were supplemented for 3‑months with the holoBLG lozenge in a previous study with two controlled HDM-AEC challenges [visits: V1, V3] were recruited for a third AEC challenge (V5) 7–8 months after cessation of supplementation. Symptoms (nose, conjunctival, bronchial, others), well-being, and lung function parameters were recorded exactly as in the previous study. Primary endpoint was change in median Total Nasal Symptom Score (TNSS) at V5 compared to V1. Secondary endpoints included e.g. change in median Total Symptom Score (TSS) and the exploratory analysis of temporal evolution of symptom scores using linear mixed effects models.

Results
Of the 32 patients included in the original study, 27 could be recruited for the follow-up visit with a third AEC challenge. An improvement of 20% (p = 0.15) in the primary endpoint TNSS [V1: 2.5 (interquartile range [IQR]: 1–4), V5: 2.0 (IQR: 1–3)] was observed; 40% (p = 0.04) improvement was seen for the TSS [V1: 5.0 (IQR: 3–9), V5: 3.0 (IQR: 2–5.5)]. Analysis of temporal evolution of all symptom scores, and the personal well-being revealed sustained, clinically meaningful improvement at V5 compared to V1. No relevant lung function parameter differences were observed.

Conclusions
Sustained long-term reduction of TNSS (primary endpoint) and sustained long-term improvement of secondary endpoints (temporal evolution of all symptom scores and well-being) were demonstrated 7–8 months after cessation of holoBLG supplementation, indicative of a long-lasting nature of immune resilience induced by holoBLG.

Trial registration
The study was registered at clinicaltrials.gov (NCT04872868).
Polynomials of Least Deviation from Zero in Sobolev p-Norm
Authors: Díaz-González Abel , Pijeira-Cabrera Héctor , Quintero-Roba Javier 
Published: January 2022

AbstractThe first part of this paper complements previous results on characterization of polynomials of least deviation from zero in Sobolev p-norm ($$1<p<\infty $$

1
<
p
<
∞

) for the case $$p=1$$

p
=
1

. Some relevant examples are indicated. The second part deals with the location of zeros of polynomials of least deviation in discrete Sobolev p-norm. The asymptotic distribution of zeros is established on general conditions. Under some order restriction in the discrete part, we prove that the n-th polynomial of least deviation has at least $$n-\mathbf {d}^*$$

n
-

d

∗

zeros on the convex hull of the support of the measure, where $$\mathbf {d}^*$$

d

∗

denotes the number of terms in the discrete part.
Genome Assembly of Alfalfa Cultivar Zhongmu-4 and Identification of SNPs Associated with Agronomic Traits
Authors: Long Ruicai , Zhang Fan , Zhang Zhiwu , Li Mingna , Chen Lin , Wang Xue , Liu Wenwen , Zhang Tiejun , Yu Long-Xi , He Fei , Jiang Xueqian , Yang Xijiang , Yang Changfu , Wang Zhen , Kang Junmei , Yang Qingchuan 
Published: January 2022

Abstract
Alfalfa (Medicago sativa L.) is the most important legume forage crop worldwide with high nutritional value and yield. For a long time, the breeding of alfalfa was hampered by lacking reliable information on the autotetraploid genome and molecular markers linked to important agronomic traits. We herein reported the de novo assembly of the allele-aware chromosome-level genome of Zhongmu-4, a cultivar widely cultivated in China, and a comprehensive database of genomic variations based on resequencing of 220 germplasms. Approximate 2.74 Gb contigs (N50 of 2.06 Mb), accounting for 88.39% of the estimated genome, were assembled, and 2.56 Gb contigs were anchored to 32 pseudo-chromosomes. A total of 34,922 allelic genes were identified from the allele-aware genome. We observed the expansion of gene families, especially those related to the nitrogen metabolism, and the increase of repetitive elements including transposable elements, which probably resulted in the increase of Zhongmu-4 genome compared with Medicago truncatula. Population structure analysis revealed that the accessions from Asia and South America had relatively lower genetic diversity than those from Europe, suggesting that geography may influence alfalfa genetic divergence during local adaption. Genome-wide association studies identified 101 single nucleotide polymorphisms (SNPs) associated with 27 agronomic traits. Two candidate genes were predicted to be correlated with fall dormancy and salt response. We believe that the allele-aware chromosome-level genome sequence of Zhongmu-4 combined with the resequencing data of the diverse alfalfa germplasms will facilitate genetic research and genomics-assisted breeding in variety improvement of alfalfa.
Foot-Launched Flying Sport Fatalities in the Canton of Berne, Switzerland
Authors: Soldati Fabio O. , Jackowski Christian , Schön Corinna A. 
Published: January 2022

Introduction Foot-launched flying sports such as paragliding, hang gliding, and speedflying are popular recreational activities that all pose a significant risk of accidents resulting in injuries or fatalities. We describe the epidemiology, incident circumstances, and findings of forensic examinations of fatalities in these sports. Methods In this retrospective analysis, we analyzed different parameters of paragliding, hang gliding, and speedflying fatalities in the canton of Berne, Switzerland, between 2000 and 2018. The data sources were police reports, forensic medical reports, the Swiss Hang Gliding Association, and the Swiss Council for Accident Prevention. Results In the given period, 40 incidents resulting in 42 fatalities were recorded (2 incidents involved 2-seaters). Three of the 40 incidents did not fulfill the inclusion criteria and were excluded. The deadliest phase was midflight. Collapse of the glider (n=9; 36%) was the leading cause of accidents among paraglider pilots. Multiple trauma (n=21; 54%) was the most frequent cause of death. In the forensic examination, all deaths (n=39) were assessed as accidents. Conclusions The different categories of foot-launched flying sports varied in the causes of accidents and deaths. Fatalities in speedflying involved young pilots exposing themselves to high-risk situations. Fatalities may be prevented by enhancing education and training and promoting a cautious attitude among pilots.
Dietary l-glutamic acid N,N-diacetic acid improves short-term maintenance of zinc homoeostasis in a model of subclinical zinc deficiency in weaned piglets
Authors: Boerboom Gavin , Ganslmaier Elena , Oeckl Josef , Busink Ronald , Martín-Tereso Javier , Windisch Wilhelm , Brugger Daniel 
Published: January 2022

AbstractThis study compared the Zn response in selected tissues of weaned piglets fed L-glutamic acid, N,N-diacetic acid (GLDA), while challenged with short-term subclinical Zn deficiency (SZD). During a total experimental period of eight days, 96 piglets were fed restrictively (450 g/d) a high phytate (9 g/kg) diet containing added Zn at 0, 5, 10, 15, 20, 25, 45 and 75 mg/kg with and without 200 mg/kg of GLDA. No animals showed signs of clinical Zn deficiency and no phenotypical differences were observed. Broken line analysis of Zn status parameters such as liver Zn and apparently absorbed Zn indicated that the gross Zn requirement threshold was around 55 mg/kg diet. Supplementation of Zn above this threshold led to a saturation of the response in apparently absorbed Zn and linear increase in liver Zn. Bone and serum Zn responded to the dose in a linear fashion, likely due to the time-frame of Zn homoeostatic adaptation. Inclusion of GLDA into the diets yielded a higher intercept for bone Zn (P < 0·05). Liver Zn accumulation and MT1A gene expression was higher for piglets receiving GLDA (P < 0·05), indicating higher Zn influx. This study indicates that a strong chelator such as GLDA mitigates negative effects of phytate in plant-based diets, by sustaining Zn solubility, thereby improving nutritional Zn availability.
Influence of crude protein content and flint maize processing methods on the performance of early-weaning Nellore calves
Authors: Godoi L. A. , Silva B. C. , Souza G. A. P. , Lage B. C. , Zanetti D. , Costa e Silva L. F. , Rennó L. N. , Paulino M. F. , Valadares Filho S. C. 
Published: January 2022

AbstractThis study aims to determine the effects of dietary crude protein (CP) content of early-weaned calves; and the influence of flint maize processing methods on intake, total tract nutrient digestibilities and performance of Nellore heifer calves. Fifteen early-weaned Nellore female calves (4 ± 0.5 months; 108 ± 13.1 kg) were used. In phase 1, animals were fed one of the following diets for 112 days: 130, 145 or 160 g CP/kg dry matter (DM). In phase 2, animals received one of the two diets for 84 days: 0.60 dry ground maize grain, 0.30 whole-plant maize silage plus 0.10 mineral-protein supplement or 0.90 snaplage plus 0.10 mineral-protein supplement. In phase 1, intake and digestibility of dietary components were not affected (P > 0.05) by increasing dietary CP content. Daily total urinary nitrogen (N) and urinary urea N increased (P < 0.05) in response to increasing dietary CP content. Animal performance was not affected (P > 0.05) by dietary CP content. In phase 2, maize processing methods did not affect (P > 0.05) intake and digestibility of dietary components as well as animal performance, carcase characteristics and carcase composition. Therefore, based on the current experimental condition, we conclude that dietary CP concentrations of 130 g/kg DM can be indicated for early-weaned Nellore calves. However, more studies are recommended to validate this result and to evaluate concentrations below 130 g CP/kg DM for early-weaned Nellore calves. Moreover, snaplage could be used as an exclusive fibre and energy source for finishing cattle in feedlot.
Critical medical ecology and intersectionality perspectives in schistosomiasis prevention and control in selected communities in Mindanao, the Philippines
Authors: Dalisay Soledad Natalia M. , Belizario Vicente Y. , Joe Joseph Aaron S. , Lumangaya Carlo R. , Cruz Reginaldo D. 
Published: January 2022

AbstractSchistosomiasis japonica remains a public health concern in many areas of the Philippines. Periodic Mass Drug Administration (MDA) to at-risk populations is the main strategy for morbidity control of schistosomiasis. Attaining MDA coverage targets is important for the reduction of morbidity and prevention of complications due to the disease, and towards achieving Universal Health Care. The study employed a qualitative case study design. Key informant interviews and focus group discussions were conducted to provide in-depth and situated descriptions of the contexts surrounding the implementation of MDA in two selected villages in known schistosomiasis-endemic provinces in Mindanao in the Philippines. Data analysis was done using the Critical Ecology for Medical Anthropology (CEMA) model coupled with the intersectionality approach. It was found that within various areas in the CEMA model, enabling as well as constraining factors have been encountered in MDA in the study settings. The interplay of income class, geographical location, gender norms and faith-based beliefs may have led to key populations being missed during the conduct of MDA in the study sites. The constraints faced by the target beneficiaries of MDA, as well as programme implementers, must be addressed to enhance service delivery and to control morbidity due to schistosomiasis. Improving compliance with MDA also requires a holistic, integrated approach to addressing barriers to participation, which are shaped by wider socio-political and power structures.
Handmaidens of the legislature? Understanding regulatory timing
Authors: Haeder Simon F. , Yackee Susan Webb 
Published: January 2022

AbstractWhen does legislation trigger regulation? The US Congress regularly passes laws that authorise government agencies to write legally binding regulations. Yet, when this occurs, agencies may take years to act – or, at times – may never act at all. We theorise that the breadth of the congressional statutory delegation drives the timing of agency policy production. In particular, when Congress expressly tells an agency to promulgate a rule, we expect agencies to do so quickly. Yet, when Congress provides greater policymaking discretion to agencies, we expect other factors – and especially, internal agency considerations – to drive regulatory timing. We use data from almost 350 statutes spanning four decades, which are then matched up with thousands of regulations, to assess the argument. Using innovative methods, we find support for our hypotheses. Overall, we produce a deeper understanding of the link between delegation and discretion: suggesting when it occurs, as well as, importantly, why.
Prevalence of anaemia and associated factors among people with pulmonary tuberculosis in Uganda
Authors: Baluku Joseph Baruch , Mayinja Ernest , Mugabe Pallen , Ntabadde Kauthrah , Olum Ronald , Bongomin Felix 
Published: January 2022

Abstract
Anaemia predicts delayed sputum conversion and mortality in tuberculosis (TB). We determined the prevalence and factors associated with anaemia among people with TB at the National Tuberculosis Treatment Centre in Uganda. People with bacteriologically confirmed TB were consecutively enrolled in a cross-sectional study between August 2017 and March 2018. Blood samples were tested for a full blood hemogram, HIV infection, and CD4+ and CD8+ T-cell counts. Anaemia was defined as a haemoglobin level of <13.0 grams per decilitre (g/dl) for males and <12.0 g/dl for females. Of 358 participants, 210 (58.7%, 95% confidence interval (CI) 53.4–63.8) had anaemia. Anaemia was associated with night sweats, a longer duration of fever, low body mass index (BMI), hyperthermia, high sputum bacillary loads, HIV co-infection, and low CD4 and CD8 counts at bivariate analysis. Factors associated with anaemia at multivariable analysis were low BMI (odds ratio (OR) 2.93, 95% CI 1.70–5.05, P < 0.001), low CD4:CD8 ratio (OR 2.54, 95% CI 1.07–6.04, P = 0.035) and microcytosis (OR 4.23, 95% CI 2.17–8.25, P < 0.001). Anaemia may be associated with the features of severe TB disease and should be considered in TB severity scores.
Beyond food swamps and food deserts: exploring urban Australian food retail environment typologies
Authors: Needham Cindy , Strugnell Claudia , Allender Steven , Orellana Liliana 
Published: January 2022

AbstractObjective:‘Food deserts’ and ‘food swamps’ are food retail environment typologies associated with unhealthy diet and obesity. The current study aimed to identify more complex food retail environment typologies and examine temporal trends.Design:Measures of food retail environment accessibility and relative healthy food availability were defined for small areas (SA2s) of Melbourne, Australia, from a census of food outlets operating in 2008, 2012, 2014 and 2016. SA2s were classified into typologies using a two-stage approach: (1) SA2s were sorted into twenty clusters according to accessibility and availability and (2) clusters were grouped using evidence-based thresholds.Setting:The current study was set in Melbourne, the capital city of the state of Victoria, Australia.Subjects:Food retail environments in 301 small areas (Statistical Area 2) located in Melbourne in 2008, 2012, 2014 and 2016.Results:Six typologies were identified based on access (low, moderate and high) and healthy food availability including one where zero food outlets were present. Over the study period, SA2s experienced an overall increase in accessibility and healthiness. Distribution of typologies varied by geographic location and area-level socio-economic position.Conclusion:Multiple typologies with contrasting access and healthiness measures exist within Melbourne and these continue to change over time, and the majority of SA2s were dominated by the presence of unhealthy relative to healthy outlets, with SA2s experiencing growth and disadvantage having the lowest access and to a greater proportion of unhealthy outlets.
Systematic review of metrics used to characterise dietary nutrient supply from household consumption and expenditure surveys
Authors: Tang Kevin , Adams Katherine P , Ferguson Elaine L , Woldt Monica , Yourkavitch Jennifer , Pedersen Sarah , Broadley Martin R , Dary Omar , Ander E Louise , Joy Edward JM 
Published: January 2022

AbstractObjective:To review existing publications using Household Consumption and Expenditure Survey (HCES) data to estimate household dietary nutrient supply to (1) describe scope of available literature, (2) identify the metrics reported and parameters used to construct these metrics, (3) summarise comparisons between estimates derived from HCES and individual dietary assessment data and (4) explore the demographic and socio-economic sub-groups used to characterise risks of nutrient inadequacy.Design:This study is a systematic review of publications identified from online databases published between 2000 to 2019 that used HCES food consumption data to estimate household dietary nutrient supply. Further publications were identified by ‘snowballing’ the references of included database-identified publications.Setting:Publications using data from low- and lower-middle income countries.Results:In total, fifty-eight publications were included. Three metrics were reported that characterised household dietary nutrient supply: apparent nutrient intake per adult-male equivalent per day (n35), apparent nutrient intake per capita per day (n24) and nutrient density (n5). Nutrient intakes were generally overestimated using HCES food consumption data, with several studies finding sizeable discrepancies compared with intake estimates based on individual dietary assessment methods. Sub-group analyses predominantly focused on measuring variation in household dietary nutrient supply according to socio-economic position and geography.Conclusion:HCES data are increasingly being used to assess diets across populations. More research is needed to inform the development of a framework to guide the use of and qualified interpretation of dietary assessments based on these data.