bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of eHealth Self-management Interventions in Patients With Heart Failure: Systematic Review and Meta-analysis
Authors: Liu Siru , Li Jili , Wan Ding-yuan , Li Runyi , Qu Zhan , Hu Yundi , Liu Jialin 
Published: September 2022

Background
Heart failure (HF) is a common clinical syndrome associated with substantial morbidity, a heavy economic burden, and high risk of readmission. eHealth self-management interventions may be an effective way to improve HF clinical outcomes.

Objective
The aim of this study was to systematically review the evidence for the effectiveness of eHealth self-management in patients with HF.

Methods
This study included only randomized controlled trials (RCTs) that compared the effects of eHealth interventions with usual care in adult patients with HF using searches of the EMBASE, PubMed, CENTRAL (Cochrane Central Register of Controlled Trials), and CINAHL databases from January 1, 2011, to July 12, 2022. The Cochrane Risk of Bias tool (RoB 2) was used to assess the risk of bias for each study. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) criteria were used to rate the certainty of the evidence for each outcome of interest. Meta-analyses were performed using Review Manager (RevMan v.5.4) and R (v.4.1.0 x64) software.

Results
In total, 24 RCTs with 9634 participants met the inclusion criteria. Compared with the usual-care group, eHealth self-management interventions could significantly reduce all-cause mortality (odds ratio [OR] 0.83, 95% CI 0.71-0.98, P=.03; GRADE: low quality) and cardiovascular mortality (OR 0.74, 95% CI 0.59-0.92, P=.008; GRADE: moderate quality), as well as all-cause readmissions (OR 0.82, 95% CI 0.73-0.93, P=.002; GRADE: low quality) and HF-related readmissions (OR 0.77, 95% CI 0.66-0.90, P<.001; GRADE: moderate quality). The meta-analyses also showed that eHealth interventions could increase patients’ knowledge of HF and improve their quality of life, but there were no statistically significant effects. However, eHealth interventions could significantly increase medication adherence (OR 1.82, 95% CI 1.42-2.34, P<.001; GRADE: low quality) and improve self-care behaviors (standardized mean difference –1.34, 95% CI –2.46 to –0.22, P=.02; GRADE: very low quality). A subgroup analysis of primary outcomes regarding the enrolled population setting found that eHealth interventions were more effective in patients with HF after discharge compared with those in the ambulatory clinic setting.

Conclusions
eHealth self-management interventions could benefit the health of patients with HF in various ways. However, the clinical effects of eHealth interventions in patients with HF are affected by multiple aspects, and more high-quality studies are needed to demonstrate effectiveness.
Study the Effect of Cutting Parameters on Temperature Distribution and Tool Life During Turning Stainless Steel 316L
Authors: Akbar Ahmed A. , Shwaish Raed R. , Hadi Naba D. 
Published: September 2022

This paper is focused on studying the effect of cutting parameters (spindle speed, feed and depth of cut) on the response (temperature and tool life) during turning process. The inserts used in this study are carbide inserts coated with TiAlN (Titanum, Aluminium and Nitride) for machining a shaft of stainless steel 316L. Finite difference method was used to find the temperature distribution. The experimental results were done using infrared camera while the simulation process was performed using Matlab software package. The results showed that the maximum difference between the experimental and simulation results was equal to 19.3 , so, a good agreement between the experimental and simulation results was achieved. Tool life was decreased when spindle speed and feed were increased.
SGLT2 Inhibition, Choline Metabolites, and Cardiometabolic Diseases: A Mediation Mendelian Randomization Study
Authors: Xu Min , Zheng Jie , Hou Tianzhichao , Lin Hong , Wang Tiange , Wang Shuangyuan , Lu Jieli , Zhao Zhiyun , Li Mian , Xu Yu , Ning Guang , Bi Yufang , Wang Weiqing 
Published: September 2022

OBJECTIVE
To investigate the causal role of choline metabolites mediating sodium–glucose cotransporter 2 (SGLT2) inhibition in coronary artery disease (CAD) and type 2 diabetes (T2D) using Mendelian randomization (MR).

RESEARCH DESIGN AND METHODS
A two-sample two-step MR was used to determine 1) causal effects of SGLT2 inhibition on CAD and T2D; 2) causal effects of three choline metabolites, total choline, phosphatidylcholine, and glycine, on CAD and T2D; and 3) mediation effects of these metabolites. Genetic proxies for SGLT2 inhibition were identified as variants in the SLC5A2 gene that were associated with both levels of gene expression and hemoglobin A1c. Summary statistics for metabolites were from UK Biobank, CAD from CARDIoGRAMplusC4D (Coronary ARtery DIsease Genome wide Replication and Meta-analysis [CARDIoGRAM] plus The Coronary Artery Disease [C4D] Genetics) consortium, and T2D from DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) and the FinnGen study.

RESULTS
SGLT2 inhibition (per 1 SD, 6.75 mmol/mol [1.09%] lowering of HbA1c) was associated with lower risk of T2D and CAD (odds ratio [OR] 0.25 [95% CI 0.12, 0.54], and 0.51 [0.28, 0.94], respectively) and positively with total choline (β 0.39 [95% CI 0.06, 0.72]), phosphatidylcholine (0.40 [0.13, 0.67]), and glycine (0.34 [0.05, 0.63]). Total choline (OR 0.78 [95% CI 0.68, 0.89]) and phosphatidylcholine (OR 0.81 [0.72, 0.91]) were associated with T2D but not with CAD, while glycine was associated with CAD (0.94 [0.91, 0.98]) but not with T2D. Mediation analysis showed evidence of indirect effect of SGLT2 inhibition on T2D through total choline (0.91 [0.83, 0.99]) and phosphatidylcholine (0.93 [0.87, 0.99]) with a mediated proportion of 8% and 5% of the total effect, respectively, and on CAD through glycine (0.98 [0.96, 1.00]) with a mediated proportion of 2%. The results were well validated in at least one independent data set.

CONCLUSIONS
Our study identified the causal roles of SGLT2 inhibition in choline metabolites. SGLT2 inhibition may influence T2D and CAD through different choline metabolites.
Prescription Patterns of Cardiovascular- and Kidney-Protective Therapies Among Patients With Type 2 Diabetes and Chronic Kidney Disease
Authors: Lamprea-Montealegre Julio A. , Madden Erin , Tummalapalli Sri Lekha , Chu Chi D. , Peralta Carmen A. , Du Yuxian , Singh Rakesh , Kong Sheldon X. , Tuot Delphine S. , Shlipak Michael G. , Estrella Michelle M. 
Published: September 2022

OBJECTIVE
To assess the prevalence and correlates of prescription of sodium–glucose cotransporter 2 inhibitors (SGLT2i) and/or glucagon-like peptide 1 receptor agonists (GLP1-RA) in individuals with type 2 diabetes mellitus (T2DM) with and without chronic kidney disease (CKD).

RESEARCH DESIGN AND METHODS
This was a cross-sectional analyses of SGLT2i and GLP1-RA prescriptions from 1 January 2019 to 31 December 2020 in the Veterans Health Administration System. The likelihood of prescriptions was examined by the presence or absence of CKD and by predicted risks of atherosclerotic cardiovascular disease (ASCVD) and end-stage kidney disease (ESKD).

RESULTS
Of 1,197,880 adults with T2DM, SGLT2i and GLP1-RA were prescribed to 11% and 8% of patients overall, and to 12% and 10% of those with concomitant CKD, respectively. In adjusted models, patients with severe albuminuria were less likely to be prescribed SGLT2i or GLP1-RA versus nonalbuminuric patients with CKD, with odds ratios (ORs) of 0.91 (95% CI 0.89, 0.93) and 0.97 (0.94, 1.00), respectively. Patients with a 10-year ASCVD risk &gt;20% (vs. &lt;5%), had lower odds of SGLT2i use (OR 0.66 [0.61, 0.71]) and GLP1-RA prescription (OR 0.55 [0.52, 0.59]). A 5-year ESKD risk &gt;5%, compared with &lt;1%, was associated with lower likelihood of SGLT2i prescription (OR 0.63 [0.59, 0.67]) but higher likelihood of GLP1-RA prescription (OR 1.53 [1.46, 1.61]).

CONCLUSIONS
Among a large cohort of patients with T2DM, prescription of SGLT2i and GLP1-RA was low in those with CKD. We observed a “risk-treatment paradox,” whereby patients with higher risk of adverse outcomes were less likely to receive these therapies.
Nationally Subsidized Continuous Glucose Monitoring: A Cost-effectiveness Analysis
Authors: Pease Anthony J. , Zoungas Sophia , Callander Emily , Jones Timothy W. , Johnson Stephanie R. , Holmes-Walker D. Jane , Bloom David E. , Davis Elizabeth A. , Zomer Ella 
Published: September 2022

OBJECTIVE
The Continuous Glucose Monitoring (CGM) Initiative recently introduced universal subsidized CGM funding for people with type 1 diabetes under 21 years of age in Australia. We thus aimed to evaluate the cost-effectiveness of this CGM Initiative based on national implementation data and project the economic impact of extending the subsidy to all age-groups.

RESEARCH DESIGN AND METHODS
We used a patient-level Markov model to simulate disease progression for young people with type 1 diabetes and compared government-subsidized access to CGM with the previous user-funded system. Three years of real-world clinical input data were sourced from analysis of the Australasian Diabetes Data Network and National Diabetes Services Scheme registries. Costs were considered from the Australian health care system’s perspective. An annual discount rate of 5% was applied to future costs and outcomes. Uncertainty was evaluated with probabilistic and deterministic sensitivity analyses.

RESULTS
Government-subsidized CGM funding for young people with type 1 diabetes compared with a completely user-funded model resulted in an incremental cost-effectiveness ratio (ICER) of AUD 39,518 per quality-adjusted life-year (QALY) gained. Most simulations (85%) were below the commonly accepted willingness-to-pay threshold of AUD 50,000 per QALY gained in Australia. Sensitivity analyses indicated that base-case results were robust, though strongly impacted by the cost of CGM devices. Extending the CGM Initiative throughout adulthood resulted in an ICER of AUD 34,890 per QALY gained.

CONCLUSIONS
Providing subsidized access to CGM for people with type 1 diabetes was found to be cost-effective compared with a completely user-funded model in Australia.
Risk factors for the development of retinopathy in pre-diabetes and type 2 diabetes: The Diabetes Prevention Program experience
Authors: White Neil H. , Pan Qing , Knowler William C. , Schroeder Emily B. , Dabelea Dana , Chew Emily Y. , Blodi Barbara , Goldberg Ronald B. , Pi-Sunyer Xavier , Darwin Christine , Schlögl Mathias , Nathan David M. , Group the DPPOS Research 
Published: September 2022

<p> </p>
<p><strong>OBJECTIVE:</strong></p>
<p>To determine glycemic and non-glycemic risk factors that contribute to the presence of diabetic retinopathy (DR) before and after the onset of type 2 diabetes (T2D).</p>
<p><strong>RESEARCH DESIGN AND METHODS:</strong> </p>
<p>During the Diabetes Prevention Program (DPP) and DPP Outcome Study (DPPOS), we performed fundus photography over time on adults at high risk to develop T2D, including after they developed diabetes. Fundus photographs were graded using the ETDRS grading system with DR defined as typical lesions of DR (microaneurysms, exudates or hemorrhage, or worse) in either eye.</p>
<p><strong>RESULTS: </strong></p>
<p>By DPPOS year 16 (approximately 20 years after randomization into DPP), 24% of 1,614 who had developed T2D and 14% of 885 who remained non-diabetic had DR. In univariate analyses, utilizing results from across the entire duration of follow-up, American Indian race was associated with less frequent DR compared to Non-Hispanic Whites (NHW), and higher HbA1c, fasting and 2-hour plasma glucose levels during an oral glucose tolerance test, weight, and history of hypertension, dyslipidemia and smoking, but not treatment group assignment, were associated with more frequent DR. On multivariate analysis, American Indian race was associated with less DR compared to NHW (OR = 0.36; 95% CI: 0.20-0.66) and average HbA1c was associated with more DR (OR = 1.92; 95% CI: 1.46-1.74 per SD [0.7%] increase in HbA1c).</p>
<p><strong>CONCLUSION:</strong> </p>
<p>DR may occur in adults with prediabetes and early in the course of T2D. HbA1c was an important risk factor for the development of DR across the entire glycemic range from prediabetes to T2D. </p>
ISOLASI DAN UJI KEMAMPUAN BAKTERI PELARUT KALIUM DARI TANAH SAWAH DENGAN SISTEM IRIGASI SUBAK
Authors: Sukmadewi Desak Ketut Tristiana , Singapurwa Ni Made Ayu Suardani , Candra I Putu 
Published: September 2022

Pemenuhan kebutuhan air yang optimal pada tanah sawah dengan sistem irigasi Subak akan mempengaruhi sifat fisik, kimia dan biologi tanah. Salah satu komponen biologi tanah yang akan dipengaruhi adalah populasi mikrob yang ada di dalam tanah. Mikrob dalam tanah yang memiliki banyak peranan penting diantaranya adalah melarutkan kalium (K), sehingga meningkatkan ketersediaan K-tanah. Tujuan dari penelitian ini adalah mengisolasi dan menguji kemampuan bakteri pelarut K dari tanah sawah dengan sistem irigasi subak. Sampel tanah yang diisolasi berasal dari Subak Sembung dan Subak Mambal. Sampel diambil dengan teknik purposive sampling hasil komposit masing-masing dari 5 titik sampling pada kedalaman 0-10 cm. Isolasi bakteri menggunakan metode spread plate dan penghitungan jumlah mikrob dilakukan menggunakan metode Total Plate Count (TPC). Bakteri hasil isolasi yang telah dimurnikan dengan metode empat kuadran diuji kemampuannya dalam melarutkan K pada media Alexandrov cair. Pengukuran K terlarut dilakukan menggunakan atomic absorption spectroscopy. Populasi bakteri pelarut K menunjukkan hasil lebih tinggi pada lokasi sampling di Subak Sembung (5,72 x 105 CFU/g) dibandingkan Subak Mambal (4,23 x 105 CFU/g). Berdasarkan hasil isolasi dan seleksi awal bakteri pelarut K didapatkan empat isolat yang mampu melarutkan K lebih tinggi dan berbeda nyata dari kontrol berdasarkan uji Duncan Multiple Range Test pada taraf nyata 5%. Keempat isolat tersebut adalah AlP6, AlP10, AlJ1 dan PKP4. Kemampuan masing-masing isolat dalam melarutkan K adalah AlP10 15,46 ppm, AlP6 12,40 ppm, PKP4 14,32 ppm, dan AlJ1 12,58 ppm. Hasil tertinggi ditunjukkan oleh isolate AlP10 dari Subak Mambal yang mampu melarutkan kalium 2 kali lipat dibandingkan dengan kontrol.
ARYLTELLUROCHLORINATION OF 4,5-DIARYL-SUBSTITUTED 3-ALLYLTHIO-1,2,4-TRIAZOLES
Authors: Kut M. , Kut D. , Onysko M. , Lendel V. 
Published: September 2022

Thiazolotriazole derivatives have a number of biological activities. Electrophilic intramolecular cyclization of unsaturated alkyl derivatives of 1,2,4-triazole under the action of various electrophilic reagents (halogens, tetrahalides of chalcogenides) is the most effective and simple method of synthesis of thiazolotriazoles.
It was previously reported that 3-metalylthio-4,5-diphenyl-1,2,4-triazole reacts with aryltellur-trichloride to form an adduct of the substrate-electrophile composition 1: 1. Therefore, the aim of this research is to study the regioselectivity of aryltelluriumchlorination of allyl thioethers 1,2,4-triazole. It was found that in different solvents 3-allylthio-4-phenyl-5- (3-chlorophenyl) -4H-1,2,4-triazole with p-methoxyphenyltellurium trichloride forms a molecular adduct of similar composition. Instead, the addition of sodium perchlorate as doping additive to the reaction medium changes the direction of the reaction and leads to the formation of 6-(dichloro-(4-methoxyphenyl)-4-tellanyl) methyl)-5,6-dihydro-3H-thiazolo perchlorate [3,2- b][1,2,4]triazolium-7.
Thus, thiazolo[3,2-b][1,2,4]triazolium salts were obtained as a result of aryl telluriumchlorination of 4,5-diaryl-substituted 3-allylthio-1,2,4-triazoles. Optimal conditions for proceeding of tellurium-induced cyclization have been found.
Hubungan Sosial Budaya Dengan Kejadian Stunting Pada Balita Usia 24-59 Bulan Di Desa Bone-Bone Kecamatan Baraka Kabupaten Enrekang Tahun 2020
Authors: Ibrahim Irviani Anwar , Alam Syamsul , Adha Andi Syamsiah , Jayadi Yusma Indah , Fadlan Muhammad 
Published: September 2022

Stunting adalah kondisi gagal pertumbuhan pada anak akibat kekurangan gizi dalam waktu yang lama. Menurut WHO, Indonesia termasuk ke dalam negara1ketiga dengan prevalensi tertinggi di regional Asia Tenggara /South-East Asia Regional (SEAR). Rata-rata1prevalensi balita stunting di Indonesia tahun 2005-2017 adalah 36,4%, sehingga persentase balita pendek di Indonesia masih tinggi. Menurut Riskesdas tahun 2018, provensi sualawesi selatan masih berada di angka 35,4% , dengan kabupaten Enrekang tertiggi ke-5 dengan persentase 42%. Data PSG tahun 2018 menunjukkan bahwa kecamatan yang memiliki prevalensi stunting tertinggi yaitu Kecamatan Baraka sebesar 45,1%. Tujuan penelitian untuk mengetahui bagaimana hubungan sosial budaya dengan kejadian stunting pada baita usia 24-59 bulan di Desa Bone-Bone Kecamatan Baraka Kabupaten Enrekang tahun 2020. Penelitian ini menggunakan metode kuantitatif dengan pendekatan cross sectional. Data dikumpulkan melalui wawancara menggunakan kuesioner dengan teknik total sampling. Jumlah populasi dalam penelitin ini adalah 34 balita, dan jumlah sampel juga sebanyak 34 balita karena menggunakan total sampling. Hasil penelitian menunjukkan bahwa terdapat hubungan antara dukungan keluarga (p=0,050) dengan kejadian stunting tidak terdapat hubungan antara sosial budaya (p=0,0281), kepercayaan makanan (p=0,089), dan pengasuhan anak (p=1.000) dengan kejadian stunting pada balita usia 24-59 bulan.
Aposentadoria especial à luz da EC 103/2019
Authors: Lang Luana Konopka , Ningeliski Adriane de Oliveira 
Published: September 2022

O presente artigo está relacionado a nova regra etária para concessão do benefício de aposentadoria especial de acordo com a reforma previdenciária. Tem como objetivo analisar a aplicabilidade do inciso I, alíneas a, b e c do artigo 19 da Emenda Constitucional 103/19 e os motivos que tornam esse dispositivo inconstitucional bem como demonstrar os fundamentos expostos na Ação Direta de Inconstitucionalidade 6.309 que corroboram com a temática, além de apresentar o contexto fático e histórico que norteiam a concessão da aposentadoria especial. O método adotado para o artigo decorre de uma ampla revisão bibliográfica em doutrinas, legislação e artigos científicos, sendo o método de abordagem o dedutivo, tendo em vista que a saúde do trabalhador é o seu principal mecanismo e a exposição prolongada a agentes nocivos é um retrocesso constitucional. Pode-se concluir que é inconstitucional a inserção de idade mínima para a concessão do benefício principalmente a partir da análise reflexiva dos fundamentos expostos na ação direta de inconstitucionalidade 6.309 de 2020.
Caracterização dos produtores rurais e sistema produtivo da viticultura no Planalto Norte Catarinense
Authors: Wurz Douglas André , Jastrombek Jessiane Mary 
Published: September 2022

Devido as condições edafoclimáticas do Planalto Norte Catarinense, entende-se que a região apresenta potencial para a viticultura. No entanto, são escassas as informações relacionadas a produção de uvas, bem como uma caracterização dos viticultores e características do sistema produtivo. Nesse contexto, tem-se como objetivo do trabalho, caracterizar o perfil do viticultor, e características do sistema produtivo na região do Planalto Norte Catarinense. A metodologia utilizada no trabalho foi um estudo de caso com os produtores de uva na região do Planalto Norte Catarinense. A coleta das informações ocorreu entre os meses de junho e agosto de 2019, através de um questionário, sendo realizado presencialmente com cada produtor rural. A análise e interpretação dos dados foram realizadas de forma ampla, correlacionando com outros conhecimentos e comparando com outros estudos. Apesar do cultivo da videira e seu processamento já serem realizadas a anos, verifica-se um volume baixo desses produtos elaborados, sendo o suco de uva o produto mais elaborado. A variedade mais cultivada na região é a Bordô, predominando o sistema de sustentação Latada, destacando-se o espaçamento de 3,0 x 2,0 m. Tendo o controle de pragas e doenças como principal entrave de produção, aliado a grande diversidade de variedades cultivadas, de sistemas de sustentação utilizados, e de espaçamentos de plantas no vinhedo, conclui-se que a atividade ainda carece de pesquisa e assistência técnica, a fim de orientar os produtores rurais a adotaram as variedades mais adaptadas em sistemas de cultivo que otimizem a produtividade sem que haja perda da qualidade da uva.
Palavras-chave: Vitis spp. Desenvolvimento regional. Suco de uva, Vinho de Mesa.
Comparative characterization of vegetable oils from bulk suppliers/vendors in Nasarawa town market in Nigeria
Authors: Musa Dallatu E. , Mariette Okorafor L. , Sotonye Wilson Arthur , Osilama Akhagbeme John 
Published: September 2022

The comparative characterization of vegetable oils from bulk suppliers/vendors was made in Nasarawa town market in Nigeria. For this a total volume of 400 cm3 vegetable oils were collected (200 cm3 from the top and 200 cm3 from the bottom of storage after stirring) separately into labeled plastic bottles from three major suppliers. Composite of each sample were made and physicochemical properties including densities, temperatures, boiling points, viscosities, refractive indexes free fatty acid, iodine values, saponification values and peroxide values were determined using standard procedures. The results showed the density of sample ranging from 0.91 ± 0.007 to 0.92 ± 0.007 gcm-3; temperature of sample: 27.3 ± 0.578 to 30.3 ± 1.525 ºC; boiling point of sample 230.7 ± 1.528 ºC to 202 ± 2.000 ºC; viscosity of sample A: 1.03 ± 0.183 to 0.72 ± 0.106 mPa.S; refractive index of sample: 1.47012 ± 0.00002 to 1.45709 ± 0.00005; free fatty acid of sample A: 0.73 ± 0.057 mgKOH/g to 0.6 ± 0.173 mgKOH/g; iodine value of sample: 87.979 ± 5.870 mgKOH/g to 54.144 ± 3.595 mgKOH/g; saponification value of sample: 195.830 ± 0.499 mgKOH/g to 197.846 ± 0.856 mgKOH/g, and peroxide value of sample A: 10.1 ± 0.741 mgKOH/g to 9.9 ± 0.663 mgKOH/g. These parameters were also compared with the standards prescribed by NAFDAC and SON, which suggest that the sampled oil is suitable for consumer use. Thus, processing of vegetable oils from industrial and locally/traditionally extracted vegetable oils and vegetable oils supplied by the three vendors in the Nasarawa town market are hereby recommended as long as the suppliers maintain the standards of production, packaging and handling.