bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual Practice Changes Post-HIV Diagnosis Among Men Who Have Sex with Men in the United States: A Systematic Review and Meta-analysis
Authors: Malekinejad Mohsen , Jimsheleishvili Sopiko , Barker Erin K. , Hutchinson Angela B. , Shrestha Ram K. , Volberding Paul , Kahn James G. 
Published: July 2022

AbstractMen who have sex with men (MSM) often change sexual behaviors following HIV diagnosis. This systematic review examined such changes, including sero-adaptive behaviors (i.e., deliberate safer-sex practices to reduce transmission risk) to better understand the magnitude of their association with HIV diagnosis. We searched four databases (1996–2017) and reviewed references from other systematic reviews. We included studies conducted in the United States that compared sexual behavior among HIV-infected “aware” versus “unaware” MSM. We meta-analytically pooled RRs and associated 95% confidence intervals (CI) using random-effects models, and assessed risk of bias and evidence quality. Twenty studies reported k = 131 effect sizes on sexual practices outcomes, most of which reported changes in unprotected sex (k = 85), and on sex with at-risk partners (k = 76); 11 reported sero-adaptive behaviors. Unprotected anal intercourse with an HIV-uninfected/unknown-status partner was less likely among aware MSM (insertive position: k = 2, RR 0.26, 95% CI 0.17, 0.41; receptive position: k = 2, RR 0.53, 95% CI 0.37, 0.77). Risk of not always serosorting among aware MSM (k = 3) was RR = 0.92 (0.83, 1.02). Existing evidence, although low-quality, suggests that HIV-infected MSM tend to adopt safer sexual practices once aware of their diagnosis. Variation in reporting of outcomes limits their comparability. Sero-adaptive behavior data are sparse.
Enacted Sexual Minority Stigma, Psychological Distress, and Sexual and Drug Risk Behaviors Among Urban Men Who Have Sex with Men (MSM)
Authors: Silvestri Francesca , Tilchin Carla , Wagner Jessica , Hamill Matthew M. , Rompalo Anne , Ghanem Khalil G. , Schumacher Christina , Ruhs Sebastian , Greenbaum Adena , Latkin Carl , Jennings Jacky M. 
Published: July 2022

AbstractUrban Black men who have sex with men (MSM) bear a disproportionate burden of HIV and syphilis in the U.S. Experiences of enacted sexual minority stigma and psychological distress among these men may be associated with HIV/STI sexual and drug risk behaviors. The objective was to determine the associations between enacted sexual minority stigma, psychological distress, and sexual and drug risk behaviors. In an urban prospective cohort study, survey measures assessed past 3-month exposure to enacted sexual minority stigma, psychological distress, and sexual and drug risk behaviors. Multivariable logistic regression models were utilized for hypothesis testing. The Black MSM (N = 140) reported the following: 22.1% experiences of enacted sexual minority stigma, 39% high levels of psychological distress, 48.6% > 1 sex partner, 8.6% transactional sex, and 6% injection drug use (IDU). In models adjusted for age and education, enacted sexual minority stigma significantly increased the odds of reporting > 1 sex partner, transactional sex, and IDU. Adjusting additionally for homelessness, the association between enacted sexual minority stigma and transactional sex remained significant. Adding psychological distress to this model showed a significant association between psychological distress and transactional sex, while the association was no longer significant for transactional sex. These findings highlight some of the complex psycho-social relationships that may be associated with sexual and drug risk behaviors among Black MSM placing them at increased risk for HIV and syphilis.
nextMONARCH Phase 2 randomized clinical trial: overall survival analysis of abemaciclib monotherapy or in combination with tamoxifen in patients with endocrine-refractory HR + , HER2– metastatic breast cancer
Authors: Hamilton Erika , Cortes Javier , Ozyilkan Ozgur , Chen Shin-Cheh , Petrakova Katarina , Manikhas Aleksey , Jerusalem Guy , Hegg Roberto , Huober Jens , Zhang Wei , Chen Yanyun , Martin Miguel 
Published: July 2022

Abstract
Purpose
Resistance to endocrine therapy poses a major clinical challenge for patients with hormone receptor-positive (HR +), human epidermal growth factor receptor 2-negative (HER2–) metastatic breast cancer (MBC). We present the preplanned 24-month final overall survival (OS) results, alongside updated progression-free survival (PFS), and objective response rate (ORR) results.

Methods
nextMONARCH is an open-label, controlled, randomized, Phase 2 study of abemaciclib alone or in combination with tamoxifen in women with endocrine-refractory HR + , HER2– MBC previously treated with chemotherapy. Patients were randomized 1:1:1 to: abemaciclib 150 mg and tamoxifen 20 mg (A + T), abemaciclib 150 mg (A-150), or abemaciclib 200 mg and prophylactic loperamide (A-200). OS was the main prespecified secondary endpoint. PFS, ORR, and safety at 24 months were compared to previously reported primary analysis results.

Results
Of the 234 patients enrolled, 12 were receiving study treatment at data cutoff (28Jun2019). Median follow-up was 27.2 months. Median OS was 24.2 months in the A + T arm, 20.8 months in A-150, and 17.0 months in A-200 (A + T versus A-200: HR 0.62; 95%CI [0.40, 0.97], P = 0.03 and A-150 versus A-200: HR 0.96; 95%CI [0.64, 1.44], P = 0.83). PFS and ORR results at 24 months were consistent with the primary analysis. The safety profile corresponded with previous reports.

Conclusion
The addition of tamoxifen to abemaciclib demonstrated greater OS benefit than monotherapy. This study confirmed the single-agent activity of abemaciclib in heavily pretreated women with endocrine-refractory HR + , HER2– MBC, as well as the previously reported primary PFS and ORR results, with no new safety signals observed.
Trial Registration ClinicalTrials.gov Identifier: NCT02747004.
Conversion of Alcohols on Stoichiometric and Reduced Rutile TiO2 (110): Point Defects Meet Bifunctionality in Oxide (Photo-)Chemistry
Authors: Mohrhusen Lars , Al-Shamery Katharina 
Published: July 2022

AbstractOxidic (photo-)catalysts have the potential to play an important role to efficiently implement sustainable feedstocks and green energy sources into future energy technologies. They may be used not only for solar energy harvesting, but also for hydrogen production or being essential for the fabrication of fine chemicals. Therefore, it is crucial to develop a detailed understanding of how the atomistic environment of the catalyst can be designed in order to promote distinct reaction pathways to influence the final product distribution of chemical reactions. In this perspective article, we survey the surface (photo-)chemistry of methanol on rutile TiO2 surfaces and hybrid catalysts based thereon. Especially the role of the surface bifunctionality by Lewis acidic and basic sites combined with the strong impact of point defects such as reduced titanium sites (mainly Ti3+ interstitials) shall be illuminated. It is shown how the selective activation of either O–H, C–H or C–O bonds in the methanol molecule can be used to tune not only the overall conversion, but to switch between oxidative and reductive routes in favor of either deoxygenation, partial oxidation or C–C coupling reactions. Especially the latter ones are of particular interest to introduce methanol from green sources such as biomass as a sustainable feedstock into already existing petrochemical technologies.
Graphical Abstract
Prevalence of Poor Mental Health Days and Adverse Childhood Experience Reporting in U.S. Adults Before and After COVID-19
Authors: Kapp Julie M. , Micheas Lada , Holmes Shannon , Stormont Melissa , Reinke Wendy M. 
Published: July 2022

AbstractThis is the first study of US adults to examine change in the prevalence of psychological burden (i.e., self-reported poor mental health days in the past 30 days, and ACEs recollections) before compared to after COVID-19 started. We analyzed the prevalence of self-reported poor mental health days, and ACEs recollections from 17 states using the Behavioral Risk Factor Surveillance System. Adjusted models identified an increase in prevalence from before compared to after COVID-19 onset in those married or partnered reporting 48% more poor mental health days in the past 30 days; persons of color reporting living with anyone with mental illness during childhood by 73% and reporting more ACEs by 35%; those employed or self-employed reporting childhood sexual abuse by 45%. This ecological-level analysis revealed population-level changes in psychological well-being reporting of U.S. adults from before compared to after the pandemic onset.
Remote video analysis of an unusual fish life-history combination: nest-building, paternal care, and protogyny in a seabream
Authors: Faure-Beaulieu Nina , Attwood Colin Graham 
Published: July 2022

AbstractSeabreams from two genera, Spondyliosoma and Spicara, have a unique life-history that combines nesting, paternal care, and protogyny. Whereas protogyny is a common sexual system among seabreams, all, except Spondyliosoma and Spicara spp., are broadcast spawners. We describe the nesting behaviour of Spondyliosoma emarginatum as a basis for analysing this unusual life-history combination. We remotely filmed males on a nesting site with over 80 nests in South Africa. It has been postulated, based on morphometric data and general observations, that males invest heavily in nest-building, courtship, and egg-guarding, although these behaviours had never been documented. Energy intensive behaviours, including the clearing of invertebrate invaders (7 counts h−1) and fanning of nests (86 counts h−1), remained constant before and after the appearance of eggs. Males spent 79.2% of their time on the nest. The remainder was spent chasing other fish species and neighbouring males (12 counts h−1) and avoiding predation. Paired spawning events proceeded in batches. Nest take-overs and sneaker male attempts were recorded. The young leave the nest immediately after hatching. Males did not feed during the 67-day nesting period. Energetic costs of nest maintenance, starvation, and predation risk explain the condensed (relative to other seabreams) 51-day spawning season. S. emarginatum meets the requirements of the SAM as nest defence requires large male body size. Their short lifespan classifies Spondyliosoma spp. as opportunists, which may explain their success across a wide range of biogeographic zones from the cold temperate North Atlantic to the subtropical western Indian Ocean. These characteristics set Spondyliosoma spp. apart from the bulk of the seabreams, which are long-lived, broadcast-spawning, periodic strategists.
Facile preparation of glycine-based mesoporous graphitic carbons with embedded cobalt nanoparticles
Authors: Wang Wenhai , Tesio Alvaro Y. , Olivares-Marín Mara , Gómez Romero Pedro , Tonti Dino 
Published: July 2022

AbstractA simple route has been developed for the preparation of mesoporous graphitic carbons with embedded cobalt nanoparticles just using glycine as a nitrogen source, cobalt nitrate and distilled water. After heating the mixture to 300 °C under magnetic stirring, a dry solid product was obtained, which was then carbonized at 900 ºC under argon atmosphere. Changing the glycine/Co molar ratio allowed controlling the size of the cobalt particles and their dispersion in the carbon matrix, the porosity of the carbon and its graphitic character. The carbon–metal composites obtained were tested as oxygen cathodes in Li–O2 batteries. Cells assembled exhibited a full discharge capacity up to 2.19 mAh cm−2 at a current of 0.05 mA cm−2 and over 39 cycles at a cutoff capacity of 0.5 mAh cm−2. This work provides a green, feasible and simple way to prepare mesoporous graphitic carbons with embedded cobalt nanoparticles without involving templates.
Graphical abstract
Room temperature deposition of freestanding BaTiO3 films: temperature-induced irreversible structural and chemical relaxation
Authors: Eckstein Udo , Khansur Neamul H. , Bergler Michael , Urushihara Daisuke , Asaka Toru , Kakimoto Ken-ichi , Sadl Matej , Dragomir Mirela , Uršič Hana , de Ligny Dominique , Webber Kyle G. 
Published: July 2022

AbstractThe room temperature aerosol deposition method is especially promising for the rapid deposition of ceramic thick films, making it interesting for functional components in energy, mobility, and telecommunications applications. Despite this, a number of challenges remain, such as an enhanced electrical conductivity and internal residual stresses in as-deposited films. In this work, a novel technique that integrates a sacrificial water-soluble buffer layer was used to fabricate freestanding ceramic thick films, which allows for direct observation of the film without influence of the substrate or prior thermal treatment. Here, the temperature-dependent chemical and structural relaxation phenomena in freestanding BaTiO3 films were directly investigated by characterizing the thermal expansion properties and temperature-dependent crystal structure as a function of oxygen partial pressure, where a clear nonlinear, hysteretic contraction was observed during heating, which is understood to be influenced by lattice defects. As such, aliovalent doping and atmosphere-dependent annealing experiments were used to demonstrate the influence of local chemical redistribution and oxygen vacancies on the thermal expansion, leading to insight into the origin of the high room temperature conductivity of as-deposited films as well as greater insight into the influence of the induced chemical, structural, and microstructural changes in room temperature deposited functional ceramic thick films.

Graphical abstract
Followers’ Motives as Moderators of the Effects of Transformational Leadership Behaviors on Follower Outcomes and Leaders’ Influence
Authors: Kehr Hugo M. , Graff Dorena , Bakaç Cafer 
Published: July 2022

Abstract
The present paper reports three studies that were based on the general proposition that the effectiveness of transformational leadership (TL) depends on whether the displayed TL behaviors match the followers’ motives. Specifically, inspirational motivation should be effective with followers high on the power motive, intellectual stimulation should be effective with followers high on the achievement motive, and individual consideration should be effective with followers high on the affiliation motive. In study 1, in order to confirm the hypothesized conceptual relationships between TL and motives, we systematically analyzed the TL literature (N = 139 papers) for motive content and found, as predicted, that descriptions of inspirational motivation, intellectual stimulation, and individual consideration were associated with power, achievement, and affiliation motive content, respectively. Study 2, a vignette study, confirmed that participants’ (N = 113) motives determined their preferences for the respective TL behaviors. In study 3 (N = 116), we manipulated TL behaviors with video clips and confirmed the predictions that followers’ affiliation [power] motive moderated the effects of individual consideration [inspirational motivation] on leaders’ influence and followers’ task performance. Mixed results were obtained regarding the expected moderating function of followers’ achievement motive on the effects of intellectual stimulation. Findings are discussed with respect to their importance in establishing TL as a motivation theory.
A Novel Homozygous Stop Mutation in IL23R Causes Mendelian Susceptibility to Mycobacterial Disease
Authors: Staels Frederik , Lorenzetti Flaminia , De Keukeleere Kerstin , Willemsen Mathijs , Gerbaux Margaux , Neumann Julika , Tousseyn Thomas , Pasciuto Emanuela , De Munter Paul , Bossuyt Xavier , Gijsbers Rik , Liston Adrian , Humblet-Baron Stephanie , Schrijvers Rik 
Published: July 2022

Abstract

Purpose
Mendelian susceptibility to mycobacterial disease (MSMD) is caused by inborn errors of IFN-γ immunity. The most frequent genetic defects are found in IL12 or a subunit of its receptor. IL23R deficiency in MSMD has only been reported once, in two pediatric patients from the same kindred with isolated disseminated Bacille Calmette-Guérin disease. We evaluated the impact of a homozygous stop mutation in IL23R (R381X), identified by whole exome sequencing, in an adult patient with disseminated non-tuberculous mycobacterial disease.

Methods
We performed functional validation of the R381X mutation by evaluating IL23R expression and IL-23 signaling (STAT3 phosphorylation, IFN-γ production) in primary cells (PBMCs, EBV-B cells) and cell lines (HeLa) with or without back-complementation of wild-type IL23R.

Results
We report on a 48-year-old male with disseminated non-tuberculous mycobacterial disease. We identified and characterized a homozygous loss-of-function stop mutation underlying IL23R deficiency, resulting in near absent expression of membrane bound IL23R. IL23R deficiency was characterized by impaired IL-23-mediated IFN-γ secretion in CD4+, CD8+ T, and mucosal-associated invariant T (MAIT) cells, and low frequencies of circulating Th17 (CD3+CD45RA−CCR4+CXCR3−RORγT+), Th1* (CD45RA−CCR4−CXCR3+RORγT+), and MAIT (CD3+CD8+Vα7.2+CD161+) cells. Although the patient did not have a history of recurrent fungal infections, impaired Th17 differentiation and blunted IL-23-mediated IL-17 secretion in PBMCs were observed.

Conclusion
We demonstrate that impaired IL-23 immunity caused by a homozygous R381X mutation in IL23R underlies MSMD, corroborating earlier findings with a homozygous p.C115Y IL23R mutation. Our report further supports a model of redundant contribution of IL-23- to IL-17-mediated anti-fungal immunity.1
The performance effects of corporate venture capital: a meta-analysis
Authors: Haslanger Patrick , Lehmann Erik E. , Seitz Nikolaus 
Published: July 2022

AbstractThe effect of corporate venture capital (CVC) investments is far from being conclusively discussed in literature. Although the expected benefits of CVCs for corporations and start-ups are undisputed, empirical evidence is mixed. We combine and analyze the results of 32 CVC studies, including 105,950 observations: Our results suggest that while CVC investments are positively linked to start-ups’ and investors’ as well as strategic performance, we find no significant relationship between CVC investments and financial outcomes. The effects are moderated by the timing of the investment, the country and industry-effects. For instance, CVC investments in North America and the ICT sector report significant positive effects, while we find no statistical evidence for the health care sector.
Towards a transregional history of secularism: Intellectual connectivity, social reform, and state-building in South and Southeast Asia, 1918–1960
Authors: Six Clemens 
Published: July 2022

AbstractThis article argues for a transregional historical approach to explain the career of political secularism, i.e. the ideas and practices that inform the modern state’s relationship to and administration of religion, in the 20th century. More specifically, it asks in how far we can understand secularism in South and Southeast Asia between the end of the First World War and decolonisation after 1945 as a result of transregional patterns that evolved within and beyond these regions. The argument is based on three brief case studies on Atatürk’s Turkey as a contested source of inspiration for state secularity and religious reform, regional women’s networks to foster secularism and social change in the 1930s, and secularism as a strategy of postcolonial state-building and territorial integration. Conceptually, the article suggests to use global intellectual history as a means to combine research on connectivity with historical comparison.
The punctuated equilibrium of scientific change: a Bayesian network model
Authors: Grim Patrick , Seidl Frank , McNamara Calum , Astor Isabell N. , Diaso Caroline 
Published: July 2022

AbstractOur scientific theories, like our cognitive structures in general, consist of propositions linked by evidential, explanatory, probabilistic, and logical connections. Those theoretical webs ‘impinge on the world at their edges,’ subject to a continuing barrage of incoming evidence (Quine 1951, 1953). Our credences in the various elements of those structures change in response to that continuing barrage of evidence, as do the perceived connections between them. Here we model scientific theories as Bayesian nets, with credences at nodes and conditional links between them modelled as conditional probabilities. We update those networks, in terms of both credences at nodes and conditional probabilities at links, through a temporal barrage of random incoming evidence. Robust patterns of punctuated equilibrium, suggestive of ‘normal science’ alternating with ‘paradigm shifts,’ emerge prominently in that change dynamics. The suggestion is that at least some of the phenomena at the core of the Kuhnian tradition are predictable in the typical dynamics of scientific theory change captured as Bayesian nets under even a random evidence barrage.
Comparison of effects of a single dose of MHYOSPHERE® PCV ID with three commercial porcine vaccine associations against Mycoplasma hyopneumoniae (Mhyo) and porcine circovirus type 2 (PCV2) on piglet growth during the nursery period under field conditions
Authors: Puig Ainhoa , Bernal Ignacio , Sabaté David , Ballarà Isaac , Montané Jordi , Nodar Lorena , Angelats Daniel , Jordà Ramon 
Published: July 2022

AbstractPigs routinely undergo stressful vaccination procedures, which are often unavoidable given the unavailability of safer alternatives, challenging animal welfare. The available vaccines forMycoplasma hyopneumoniae(Mhyo) or Porcine circovirus type 2 (PCV2) are mostly administered intramuscularly in association to prevent Porcine respiratory disease complex (PRDC). MHYOSPHERE® PCV ID is the first vaccine protecting from both agents by intradermal route. This randomized, blind-field trial aimed to compare the effects of MHYOSPHERE® PCV ID with those of three different intramuscular associations of commercially available vaccines. A total of 7072 21-day-old piglets from 12 consecutive batches in one farm were randomly vaccinated with MHYOSPHERE® PCV ID (G1) or Ingelvac CircoFLEX® + Hyogen® (G2), Porcilis® PCV + M + PAC® (G3), and Porcilis® PCV + Hyogen® (G4). Growth performance during the nursery period and adverse reactions (ARs) after vaccine administration were monitored. Average Daily Weight Gain (ADWG) during the first 7 days post-weaning in G1 was 10.92, 3.03, and 20.08 g/day higher than in G2, G3, and G4, respectively, and 0.65, 4.06, and 9.58 g/day higher than in G2, G3, and G4 during the entire nursery period, respectively. G1 ADWG was significantly higher than G4 during both periods and significantly higher than G2 during the first 7 days post-weaning. Incidence of systemic ARs in G2 and G4 was 0.03% and 0.32%, respectively; none were recorded in G1 and G3. Replacing the usual intramuscular vaccination with MHYOSPHERE® PCV ID results in higher growth performance during the first weeks after weaning with no systemic ARs.