bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Banana (Musa sp.) Peels Extract in Nanoemulsion Dosage Forms
for the Improvement of Memory: In Vitro & In Vivo Studies
Authors: Al-Hakim Nur Achsan , Fidrianny Irda , Anggadiredja Kusnandar , Mauludin Rachmat 
Published: April 2022

Background:
Banana (Musa sp.) is a plant that is rich in phytochemical compounds, especially antioxidant, which is hypothesized to inhibit the activity of acetylcholinesterase, an enzyme associated with Alzheimer's Disease.

Objective:
The aims of this research were to study nanoemulsion preparations of Kepok banana (KEP-NE) and Tanduk banana (TAN-NE) peel extracts for their activities as antioxidants, acetylcholinesterase as well as tyrosinase inhibitors, and as agents to improve short-term memory.

Methods:
Nanoemulsion was prepared using a combination of high shear homogenization and ultrasonication. The antioxidant activity test was carried out using DPPH and ABTS methods. Meanwhile, memory improvement was studied in a mouse model with memory impairment induced by alloxan (120 mg/kg b.w) using Y-maze apparatus. Determination of acetylcholinesterase and tyrosinase inhibition were performed by ELISA.

Results:
Characterization of the nanoemulsion was performed to include particle size, antioxidant activity, acetylcholinesterase, and tyrosinase inhibition. The particle size and polydispersity index (PI) of KEP-NE and TAN-NE were 84.2 nm (PI: 0.280) and 94.1 nm (PI: 0.282), respectively. The antioxidant activity of DPPH showed that the respective IC50 values of KEP-NE and TAN-NE were 0.64 µg/mL and 1.97 µg/mL. While the values with the ABTS method were 1.10 µg/mL and 1.72 µg/mL, respectively. The IC50 of KEP-NE on acetylcholinesterase inhibition was 108.80 µg/mL, and that on tyrosinase inhibition was 251.47 µg/mL. The study of short-term memory test in Y-maze revealed that the groups Kepok peel extracts 100 and 300 mg/kg b.w, and KEP-NE 100 and 300 mg/kg b.w significantly (P < 0.05) improved short-term memory.

Conclusion:
This study suggests that the nanoemulsion dosage form of Kepok banana peel extract have antioxidant and acetylcholinesterase inhibition as well as tyrosinase inhibition activities and could be potential as an adjunct alternative treatment for memory disorders. The modification of the smaller drug particle size makes an active contribution to the delivery system. The nanoemulsion can increase pharmacological activity
Biological Activity of Synthetic Organoselenium Compounds: What do we Know about the Mechanism?
Authors: Nogara Pablo Andrei , Bortoli Marco , Orian Laura , Rocha João Batista T. 
Published: April 2022

Abstract:Low-molecular-mass selenium (LMM-Se) molecules, such as ebselen and diphenyldiselenide, have many biological and potential therapeutic activities; however, little is known about their mechanism of action. It has been stipulated that LMM-Se can modify the physiological chemistry of endogenous thiol (–SH) and selenol (–SeH) groups by different mechanisms. Generically, LMM-Se compounds are poor mimetics of glutathione peroxidase (GPx) enzyme, suggesting that their thiol-modifier effect is more reasonable to justify their biological action. Unfortunately, the LMM-Se interactions with their targets are relatively non-specific. Here, the action of LMM-Se as potential therapeutic agents will be discussed, as well as the bottleneck and myths about their potential use as therapeutic agents.
Using Natural Language Processing and Machine Learning to Preoperatively Predict Lymph Node Metastasis for Non–Small Cell Lung Cancer With Electronic Medical Records: Development and Validation Study
Authors: Hu Danqing , Li Shaolei , Zhang Huanyao , Wu Nan , Lu Xudong 
Published: April 2022

Background
Lymph node metastasis (LNM) is critical for treatment decision making of patients with resectable non–small cell lung cancer, but it is difficult to precisely diagnose preoperatively. Electronic medical records (EMRs) contain a large volume of valuable information about LNM, but some key information is recorded in free text, which hinders its secondary use.

Objective
This study aims to develop LNM prediction models based on EMRs using natural language processing (NLP) and machine learning algorithms.

Methods
We developed a multiturn question answering NLP model to extract features about the primary tumor and lymph nodes from computed tomography (CT) reports. We then combined these features with other structured clinical characteristics to develop LNM prediction models using machine learning algorithms. We conducted extensive experiments to explore the effectiveness of the predictive models and compared them with size criteria based on CT image findings (the maximum short axis diameter of lymph node >10 mm was regarded as a metastatic node) and clinician’s evaluation. Since the NLP model may extract features with mistakes, we also calculated the concordance correlation between the predicted probabilities of models using NLP-extracted features and gold standard features to explore the influence of NLP-driven automatic extraction.

Results
Experimental results show that the random forest models achieved the best performances with 0.792 area under the receiver operating characteristic curve (AUC) value and 0.456 average precision (AP) value for pN2 LNM prediction and 0.768 AUC value and 0.524 AP value for pN1&N2 LNM prediction. And all machine learning models outperformed the size criteria and clinician’s evaluation. The concordance correlation between the random forest models using NLP-extracted features and gold standard features is 0.950 and improved to 0.984 when the top 5 important NLP-extracted features were replaced with gold standard features.

Conclusions
The LNM models developed can achieve competitive performance using only limited EMR data such as CT reports and tumor markers in comparison with the clinician’s evaluation. The multiturn question answering NLP model can extract features effectively to support the development of LNM prediction models, which may facilitate the clinical application of predictive models.
Exploring Online Peer Support Groups for Adults Experiencing Long COVID in the United Kingdom: Qualitative Interview Study
Authors: Day Hannah L S 
Published: April 2022

BackgroundLong COVID is an emerging public health concern. A growing number of individuals are experiencing prolonged, multifaceted health challenges and accompanying social impacts after COVID-19 infections. Support services in the United Kingdom remain insufficient and fraught with complexity. Responding to persistent gaps in care, patients joined forces in online peer support groups. However, little is known about how these groups impact patients with long COVID and their lived experiences of the condition.ObjectiveThe aim of this study is to explore the roles that online peer support groups take on and the impact they have on patients experiencing and recovering from long COVID in the United Kingdom. In doing so, this study aims to identify ways to inform future long COVID care, including online peer support and broader long COVID care structures.MethodsI conducted 11 semistructured interviews virtually on Zoom in July 2021. Participants had long COVID, were UK-based, and used long COVID online peer support groups. Topics discussed in interviews included what led participants to these groups, experiences within them, and feelings about the roles that the groups took on. I analyzed the results by manually conducting thematic analysis.ResultsLong COVID online peer support groups had numerous roles, significantly impacting users. I identified 5 themes and 13 subthemes through thematic analysis. The identified themes were as follows: (1) filling professional care gaps, (2) societal awareness, (3) engagement behavior, (4) diversity, and (5) social connections. Given the void of professional support, those experiencing long COVID gained some benefit from these groups. However, participants emphasized notable concerns about the all-encompassing roles these groups embody and speculated over potential improvements.ConclusionsIf used appropriately, online peer support groups could be immensely beneficial for patient well-being, beyond simply filling gaps in long COVID care. However, it appears many groups take on more than they can manage and become potentially harmful. Through prioritizing patient voices, long COVID care could be restructured to maximize peer support’s benefits within broader care structures.
Engagement With HIV and COVID-19 Prevention: Nationwide Cross-sectional Analysis of Users on a Geosocial Networking App
Authors: Gaither Thomas W , Sigalos John T , Landovitz Raphael J , Mills Jesse N , Litwin Mark S , Eleswarapu Sriram V 
Published: April 2022

Background
Geosocial networking (GSN) apps play a pivotal role in catalyzing sexual partnering, especially among men who have sex with men.

Objective
To quantify the prevalence and disparities in disclosure of pre-exposure prophylaxis (PrEP) use and COVID-19 vaccination among GSN app users, mostly men who have sex with men, in the United States.

Methods
Web-based Grindr profiles from the top 50 metropolitan areas as well as the 50 most rural counties in the United States by population were randomly sampled. Grindr provides an option to disclose current PrEP use (HIV positive, HIV negative, or HIV negative with PrEP use). The free text in all profiles was analyzed, and any mention of COVID-19 vaccination was recorded. Multivariable logistic regression to assess independent associations with PrEP disclosure and COVID-19 vaccination was performed. Imputation analyses were used to test the robustness of the results.

Results
We evaluated 1889 urban and 384 rural profiles. Mean age among urban profiles was 32.9 (SD 9.6) years; mean age among rural profiles was 33.5 (SD 12.1) years (P=.41). Among the urban profiles, 16% reported being vaccinated against COVID-19 and 23% reported PrEP use compared to 10% and 8% in rural profiles, respectively (P=.002 and P<.001, respectively). Reporting COVID-19 vaccination (adjusted odds ratio [aOR] 1.7, 95% CI 1.2-2.4), living in an urban center (aOR 3.2, 95% CI 1.8-5.7), and showing a face picture as part of the Grindr profile (aOR 4.0, 95% CI 2.3-7.0) were positively associated with PrEP disclosure. Self-identified Black and Latino users were less likely to report PrEP use (aOR 0.6, 95% CI 0.4-0.9 and aOR 0.5, 95% CI 0.4-0.9, respectively). Reporting PrEP use (aOR 1.7, 95% CI 1.2-2.4), living in an urban center (aOR 2.5, 95% CI 1.4-4.5), having a “discreet” status (aOR 1.6, 95% CI 1.0-2.5), and showing a face picture (aOR 2.7, 95% CI 1.5-4.8) were positively associated with reporting COVID-19 vaccination on their profile. Users in the southern United States were less likely to report COVID-19 vaccination status than those in the northeast United States (aOR 0.6, 95% CI 0.3-0.9).

Conclusions
Variations in PrEP disclosure are associated with race, whereas COVID-19 vaccination disclosure is associated with geographic area. However, rural GSN users were less likely to report both PrEP use and COVID-19 vaccination. The data demonstrate a need to expand health preventative services in the rural United States for sexual minorities. GSN platforms may be ideal for deployment of preventative interventions to improve access for this difficult-to-reach population.
Kepemimpinan Nabi Sulaiman dalam Al-Qur’an
Authors: Zulihafnani Zulihafnani , Husaini Khalil 
Published: April 2022

Leaders are people who undergo leadership. So far, there have been many misunderstandings about the meaning of leadership. In general, people see the leader as a position or a mere position. As a result, many people are pursuing to become a leader by justifying various ways to achieve these goals. This study discusses the verses of the Koran that talk about leadership by looking at the leadership model of the Prophet Solomon. This research is in the form of library research. There are three types of data collection, namely primary, secondary and tertiary data. Data collection techniques are carried out by collecting all data related to the subject matter. Then the author analyzes the content analysis method in the form of the maudu'i method so that the right answer is obtained. The story of Prophet Solomon is told in the Koran 16 times. The leadership concept contained in the story of Prophet Sulaiman is management ability, social responsibility, discipline, and firmness, checking all reports and conducting investigations into reports, and upholding the morals of a leader where a leader is not easily deceived by property. So with this leadership concept, Prophet Sulaiman's leadership stood firmly and was respected by his opponents. Pemimpin adalah orang yang menjalani kepemimpinan. Selama ini banyak sekali kekeliruan pemahaman tentang arti kepemimpinan. Pada umumnya, orang melihat pemimpin adalah sebuah kedudukan atau posisi semata. Akibatnya banyak orang yang mengejar untuk menjadi seorang pemimpin dengan menghalalkan berbagai cara dalam mencapai tujuan tersebut. Penelitian ini membahas tentang ayat-ayat Alquran yang berbicara tentang kepemimpinan dengan melihat pada model kepemimpinan Nabi Sulaiman. Penelitian ini berupa penelitian kepustakaan (library research), dalam pengumpulan data ini ada tiga jenis yaitu, data primer, sekunder dan tersier. Teknik pengumpulan data dilakukan dengan cara mengumpulkan seluruh data yang berkaitan dengan pokok permasalahan. Kemudian penulis analisa dengan metode analisa isi dalam bentuk metode maudu’i, sehingga diperoleh jawaban yang tepat. Kisah Nabi Sulaiman diceritakan dalam Alquran sebanyak 16 kali. Konsep kepemimpinan yang terdapat dalam kisah Nabi Sulaiman ialah, kemampuan manajemen, tanggung jawab sosial, kedisiplinan dan ketegasan, melakukan pemeriksaan terhadap segala laporan dan melakukan penyelidikan terhadap laporan, dan menjunjung tinggi moral seorang pemimpin yang mana seorang pemimpin tidak mudah diperdaya oleh harta benda. Sehingga dengan konsep kepemimpinan ini membuat kepemimpinan Nabi Sulaiman berdiri dengan kokoh, dan disegani oleh lawan-lawannya.
Cox-Maze IV in elderly atrial fibrillation patients
Authors: Ding Dan , Wu Jiawei , Fan Yilun , Xue Song , Huang Ritai 
Published: April 2022

BACKGROUD: More and more older patients experiencing atrial
fibrillation（AF）with other structural heart diseases select the
constant Cox-Maze IV procedure during cardiac surgery, but few studies
have reported whether the older patients benefited from the Cox-Maze IV
procedure. The purpose of this report is to present a retrospective
analysis of the use of the Cox-Maze IV procedure in the elderly.
METHODS: All participants in our center who underwent the
concomitant Cox-Maze IV procedure from January 2011 to September 2018
were included in the study. The clinical data of the patients were
analyzed, and inclusion and exclusion criteria were implemented.
Multivariate analysis was performed to evaluate the effect of the
constant Cox-Maze IV procedure on elderly patients with AF.
RESULTS: A total of 57 patients aged ≥70 years (73.00±2.68
years) were compared to 269 patients aged <70 years
(56.94±8.99 years). During follow-up, atrial fibrillation recurred in 79
(24.23%) patients. The total sinus maintenance rates were 88.7%,
84.5%, and 74.9% after 1, 2, and 3 years, respectively. In
multivariable models, factors of aging [HR: 1.84 (1.02-3.32),
p<0.05], female sex [HR: 1.72 (1.08-2.74),
p<0.05], hypertension [HR: 2.16 (1.21-3.83),
p<0.05], left atrial diameter [HR: 1.05 (1.03-1.08),
p<0.05], and aortic surgery [HR: 0.52 (0.29-0.94),
p<0.05] were associated with AF recurrence.
CONCLUSIONS: Aging is a novel risk factor for atrial
fibrillation recurrence. Patient sex, age, left atrial diameter, and
hypertension should all be taken into account in deciding if elderly
patients suffering from AF should undergo the Cox-Maze procedure.
Keywords: Atrial fibrillation; Cox-Maze IV; Risk factor;
Elderly
Lessons from a Tax Education Pioneer: A Tribute to Edward J. Filbey
Authors: Holley Brandi L. , Simer Joshua L. 
Published: April 2022

ABSTRACT
Edward J. Filbey joined the accounting faculty at the University of Illinois at Urbana-Champaign in 1919 to establish the university's taxation curriculum. His education background of philosophy and the classics was unique for an accounting academician, but his career as a tax educator was impressive and worthy of celebration. Filbey was a well-rounded faculty member who excelled in scholarship, teaching, and service throughout his career. He authored papers published in top accounting journals, taught various accounting courses at the undergraduate and graduate level for nearly three decades, and served in various officer roles in several academic and professional associations. His tax textbook, one of the first written, was used at universities across the United States. Accounting and tax educators would do well to learn from and follow his career. This paper pays tribute to Filbey, but also highlights specific lessons educators can learn from his career.
Perbedaan Kematangan Emosi Antara Remaja Yang Mendapatkan Pelatihan Life Skill Dengan RemajaYang Tidak Mendpatkan Pelatihan Life S di LAPAS Kelas II A Anak Medan
Authors: Munthe Rismawati 
Published: April 2022

Tujuan dari penelitian ini yaitu untuk mengetahui apakah ada perbedaan dalam kematangan emosi remaja yang mendaptkan pelatihan life skill dan remaja yang tidak diberikan pelatihan life skill di lembaga Permasyarakatan kelas II A Anak Medan. Populasi dalam penelitian sebanyak 628 orang, sedangkan sampel yang digunakan dalam penelitian ini sebanyak 40 orang. Analisis data dalam penelitian ini menggunakan analisis statistik.Berdasarkan hasil perhitungan uji beda (t-test) diketahui bahwa ada perbedaan kematangan emosi yang sangat signifikan antara remaja yang mengikuti pelatiahan life skill dan remaja yang tidak mengikuti pelatihan life skill, hasil ini dapat dinilai dari nilai koefisien t-test = 12,213 dan nilai p > 0,001. Hasil analisis menunjukkan mean remaja yang mengikuti pelatihan life skill dengan mean = 162.2000 lebih tinggi dari pada mean remaja yang tidak mengikuti pelatihan life skill dengan mean = 113.7000.Disarankan Bagi remaja yang aktif dalam keterampilan life skill disarankan untuk dapat lebih baik dalam mengembangankan kematangan emosinya, baik saat masih berada didalam Lapas ataupun saat setelah bebas nanti.Katakunci: Remaja, Kematangan Emosi, Life Skill
A aplicação dos critérios de qualidade editorial do Catálogo 2.0 do Latindex nas revistas científicas brasileiras: uma análise preliminar
Authors: Campos Fhillipe de Freitas , Vilas Boas Raphael Faria , Amaro Bianca 
Published: April 2022

Objetivo: O estudo analisa preliminarmente a aplicação dos critérios de qualidade editorial do Catálogo 2.0 do indexador Latindex nas revistas científicas brasileiras e revela quais são os critérios de qualidade editorial que as revistas avaliadas menos cumprem, servindo como parâmetro aos editores que desejam solicitar avaliação de suas revistas ao longo da vigência do Catálogo 2.0. Metodologia: A partir de uma abordagem quantitativa, descritiva e exploratória o estudo utiliza os dados gerados durante as avaliações de revistas para o Catálogo 2.0 do Latindex para compreender a qualidade editorial das revistas avaliadas. Resultados: Os resultados obtidos mostram que as revistas até então avaliadas têm obtido alta taxa de reprovação no indexador Latindex, mas estas reprovações estão maiormente associadas ao descumprimento de critérios pontuais e que podem ser facilmente sanados, desde que editores e equipes editoriais atentem-se às especificidades requeridas pelo indexador. Conclusões: As revistas científicas brasileiras avaliadas para o Catálogo 2.0 do Latindex apresentam taxas de reprovação acima de 50% e tendem a descumprir critérios de qualidade editorial importantes para a garantia da cientificidade deste tipo de publicação. Critérios como “Geração contínua de conteúdos”, “Sistema de avaliação por pares”, “Afiliação institucional dos membros do conselho editorial”, “Exigência de originalidade”, “Detecção de plágio”, “Uso de protocolos de interoperabilidade” estão entre aqueles que apresentam as maiores taxas de não cumprimento. Por outro lado, muitas revistas avaliadas têm obtido êxito na avaliação e cumprido estes mesmos critérios, o que traça um cenário promissor em relação à qualidade editorial dessas revistas. Compete aos editores e equipes editoriais das revistas científicas brasileiras atentar-se ao cumprimento destes critérios, uma vez que eles são cobrados por praticamente todos os serviços de informação de revistas científicas e, portanto, o impacto gerado não restringe-se somente ao Latindex.
CREATION AS A MEANING OF PERSONAL PSYCHOLOGY
Authors: Avetisyan Armen 
Published: April 2022

ABSTRACT
The aim of this study is to clearly define creativity as a means of reflecting a person’s psyche, linking it to creation from the perspective of different researchers.
Literature review as a research method has been used for theoretical analyses of the existing literature reflecting the personality and creativity. This paper discusses literature review as a methodology for conducting research and offers an overview of different researchers on the topic of the study.
The analysis of the research results made it possible to compile understanding of creation or creativity as a meaning of personal psychology from the perspective of different authors. Results of the study indicate that creativity itself is quite complicated and it applies on in each component of the personality and still the reflection is different and ideology behind various from different perspectives. Still, there is no any unique understanding of creativity or creation while talking about personal psychology.
PSYCHOLOGICAL VIEWS OF STEPANOS LEHATSY
Authors: Stepanyan Narine , Nazaryan Ani 
Published: April 2022

ABSTRACT
Stepanos Lehatsy is one of Armenia's greatest thinkers of the 17th century He is the author of many translations of philosophical works of worldwide significance, among which the most important are "Metaphysics" and "On the Soul" of Aristotle, together with the translator's comments, four famous works of Dionysius the Areopagite, "Jewish War” of Flavius Josephus, also Ecclesiasticus ("The Book of Sirach"), "The Quran" and other translations. Of his own philosophical works, “Banq imastasirakanq ev astvatsabanakanq hamarotabar ibr sahmanoren artadrealq ev havaqealq yst aybubeni” (“Philosophical-theological words, which are written in summary, that is, separated, grouped in alphabetical order", in Old Armenian (Grabar)) is a great value volume dictionary, in which apart from the philosophical, theological, ethical and aesthetic issues also psychological problems are discussed.
From a psychological point of view, the most interesting is the theory of knowledge of Stepanos Lehatsy. Understandings on the human soul and will are also given in his psychological views.
THE FOUNDATION AND DEVELOPMENT OF ARMENIAN PSYCHOLOGICAL THOUGHT
Authors: Yesayan Gor 
Published: April 2022

In this paper discussed the works of Armenian philosophers about human psyche in chronological order. It also referred to the works of Armenian psychologists and their possible role in the creation of an Armenian psychological direction.
The last part of the article introduces the Armenian psychologist A. I. Mirakyan's scientific concept, which is known as "Transcendental Psychology". The work also presents the role of transcendental psychology in the new solution of the current problems facing psychology.