bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimation of Post-therapeutic Liver Reserve Capacity Using 99mTc-GSA Scintigraphy Prior to Carbon-ion Radiotherapy for Liver Tumors
Authors: Yamazaki Kana , Nishii Ryuichi , Mizutani Yoichi , Makishima Hirokazu , Kaneko Takashi , Isobe Yoshiharu , Terada Tamasa , Tamura Kentaro , Imabayashi Etsuko , Tani Toshiaki , Kobayashi Masato , Wakatsuki Masaru , Tsuji Hiroshi , Higashi Tatsuya 
Published: May 2022

Abstract
Background: There is currently no established imaging method for assessing liver reserve capacity prior to carbon-ion radiotherapy (CIRT) for liver tumors. In order to perform safe CIRT, it is essential to estimate the post-therapeutic residual reserve capacity of the liver. Purpose: To evaluate the ability of pre-treatment 99m Tc-GSA scintigraphy to accurately estimate the residual liver reserve capacity in patients treated with CIRT for liver tumors. Materials and Methods: This retrospective study evaluated 50 patients who were performed CIRT for liver tumors between December 2018 and September 2020 and underwent 99m Tc-GSA scintigraphy before and 3 months after CIRT, Gd-EOB-DTPA-enhanced MRI within 1 month before CIRT were evaluated. The maximal removal rate of 99m Tc-GSA (GSA-Rmax) was analyzed for the evaluation of pre-treatment liver reserve capacity. Then, the GSA-Rmax of the estimated residual liver (GSA-RL) was calculated using liver SPECT images fused with the Gd-EOB-DTPA-enhanced MRI. GSA-RL before CIRT and GSA-Rmax at 3 months after CIRT were compared using non-parametric Wilcoxon signed-rank test and linear regression analysis. Results: Overall, 50 patients were included (mean age ± standard deviation, 73 years ± 11; range, 29–89 years, 35 men). The median GSA-RL was 0.393 [range, 0.057–0.729] mg/min, the median GSA-Rmax after CIRT was 0.369 [range, 0.037–0.780] mg/min ( P = .40). The linear regression equation representing the relationship between the GSA-RL and GSA-Rmax after CIRT was y = 0.05 + 0.84x (R 2 = 0.67, P < .0001). There was a positive correlation between the estimated and actual post-treatment values for all patients, as well as in the group with impaired liver reserve capacity (y = - 0.02 + 1.09x (R 2 = 0.62, P = .0005)). Conclusions: 99m Tc-GSA scintigraphy has potential clinical utility for estimating the residual liver reserve capacity in patients undergoing carbon-ion radiotherapy for liver tumors. Clinical Trial registration: UMIN000038328, https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000043545
Combination effect of smoking conditions and Dunaliella salina as natural antioxidant on biochemical characters of stored Sander lucioperca fillets
Authors: Bouriga N. , Mili S. , Troudi D. , Atitallah A. Ben , Bahri W. Rjiba , Bejaoui S. , Quignard J.-P. , trabelsi M 
Published: May 2022

Abstract
Sander lucioperca is a fresh water fish characterized with its remarkable nutritional value. Thus, smoking improves sensory and microbiological characteristics. Therefore smoking processes is associated to alterations in some physicochemical fish properties. The object of this study is to evaluate the combined effects of two different processes of smoking (cold and hot) and natural antioxidants obtained from the microalgea Dunaliella salina administrated at two graded concentrations (+0.5pp and +1pp) on the biochemical quality and shelf life of Sander lucioperca fillets were investigated during 1, 20 and 90 days of storage.Smoking Sander lucioperca using Dunaliella salina extract increases polyphenols content in the fillets smoked fish. This natural antioxidant leads to a better preservation for this smoked fish. Dunaliella salina increases of the amounts of lipids and decreases TVBN, PV, TBARS and FFA in cold and hot smoked fillets. Therefore, combined effects of two different processes of smoking (cold and hot) and natural antioxidants could be a promising technique to preserve the Sander lucioperca fillets quality.
Characterization and associated risk factors of thrombotic thrombocytopenic purpura in autoimmune related diseases: a retrospective study
Authors: Zhou Liling , Shen Guifen , Li Ling , Zhong Jixin , Dong Lingli 
Published: May 2022

Abstract
Objectives: As a rare but serious disease with high mortality, the features and risk factors of thrombotic thrombocytopenic purpura (TTP) in underlying autoimmune related diseases (AIRDs) are not well characterized.Methods: We retrospectively reviewed the electronic medical records of TTP patients with AIRDs who were hospitalized in Tongji Hospital from January 2017 to August 2021. 120 AIRDs patients with severe thrombocytopenia were included as controls. Statistical analysis involved Student's t test, Mann-Whitney U test, Chi-squared test, Fisher's exact test, and univariate logistic regression.Results: The prevalence of TTP in AIRD patients was 1.541‰, with a high mortality of 32.26% in this study. Lower platelet count, higher LDH level, higher cTnI level, more frequent proteinuria and coma on admission were observed in non-survivors when compared with survivors. History of thrombocytopenia, antiphospholipid antibody (aPL) positivity, neurologic symptoms, anti-SSB positivity, proteinuria and hematuria were associated with TTP in AIRD patients who had severe thrombocytopenia. Levels of IBIL, LDH, Hb, cTnI, and D-Dimer had good capabilities to discriminate TTP from severe thrombocytopenia in patients with AIRD.Conclusion: AIRD-TTP is a rare emergency with a high mortality rate of 32.26%. Organ damages, severities of thrombocytopenia and hemolysis on admission were associated with the outcome of AIRD-TTP patients. Levels of IBIL, LDH, Hb, cTnI, and D-Dimer may provide important information for the diagnosis of AIRD-TTP.
Application of Factorial and Binomial identities in Computing and Cybersecurity
Authors: Annamalai Chinnaraji 
Published: May 2022

Abstract
This paper focuses on the application of factorial and binomial identities in computing, communication, and cybersecurity in connection with the symmetric and asymmetric encryptions. We can use the binomial identities and theorem in factorials as an effective security algorithm to protect the computing systems, programs, and networks.
The relationship between the severity of obsessive compulsive disorder (OCD) and Alzheimer's disease (AD) and frontotemporal dementia (FTD)
Authors: Dadkhah Romina , Baradaran Hamid Reza , Almasi-Dooghaee Mostafa , Janmohammadi Farahnaz , Shalbafan Mohammadreza , Heidari Amirreza , jazayeri mina 
Published: May 2022

Abstract
Introduction: Given the prevalence of obsessive-compulsive disorder(OCD), we investigated the association between the severity of OCD and Alzheimer's and frontotemporal dementia.Method: This case-control study included patients referred to the dementia clinic of Firoozgar Hospital and the Brain and Cognition Clinic, who had a Montreal Cognitive Assessment (MOCA) test score less than 26 based on assessments of known Alzheimer's or frontotemporal dementia. The control group also consisted of people who referred to the neurology clinic without complaining of psychiatric disorders. For evaluating the severity of OCD we used the Yale – Brown Obsessive Compulsive Scale (Y-BOCS) questionnaire. Results: This study was performed on 13 patients with Alzheimer's disease, 13 patients with FTD and 26 healthy controls. The MOCA score in the two groups of patients was significantly lower than the control group (P <0.001) and is was not statistically significant between the two groups (P> 0.05). The severity of OCD was significantly higher in FTD )25.76±7.16 (and Alzheimer's patients )18.15±9.50( compared to the control group (7.07±5.70) (P <0.001). Also, the severity of OCD was was higher in the FTD group compared to the Alzheimer's group (P = 0.03). Conclusion: Thus, the severity of OCD in the group of FTD and Alzheimer's patients was higher compared to the control group and also the severity of OCD was higher in the FTD group compared to the Alzheimer's group.
Surgical Approach to Pediatric Mediastinal Masses Based on Imaging Characteristics
Authors: Young Stephanie , Rettig R. Luke , Hutchinson Ian V. , Sutcliffe Michael G. , Lee Jennifer A. , Sydorak Roman M. 
Published: May 2022

Abstract
BACKGROUND: Pediatric mediastinal masses may be resected using an open or video-assisted thoracoscopic surgery (VATS) approach. We sought to define the preoperative imaging findings predicting amenability to VATS. METHODS: This multicenter retrospective study of pediatric patients undergoing either VATS or open surgical mediastinal mass resection between 2008-2018 evaluated the preoperative imaging descriptors associated with VATS. Postoperative endpoints included length of stay (LOS), 30-day readmission, 90-day mortality and complication rates. RESULTS: Mediastinal mass resection was performed in 33 patients. Median tumor size was 6 cm, and 51.5% had anterior mediastinal tumors. The 23 (69.7%) patients who underwent VATS were significantly older (144 months vs 32, P=0.01) and larger (33.6 kg vs 13.8 P=0.03). Preoperative imaging characteristics in VATS included “well circumscribed”, “smooth margins” and “cystic”, while the open surgery group were “heterogeneous” and “coarse calcification”. The open group had more germ cell tumors (60.0% vs 13.0%, P=0.16) but no difference in malignancy. VATS patients had shorter LOS (2 days vs 6.5, P=0.24). Readmission, complication and mortality rates were similar.CONCLUSION: Pediatric patients with apparent malignancy frequently underwent open resection compared with the thoracoscopic group, although final malignant pathology was similar. Equivalent outcomes and shorter LOS should favor a minimally invasive approach.LEVEL OF EVIDENCE: Level III
Clinical utility of chromosomal microarray analysis and whole exome sequencing in fetuses with oligohydramnios
Authors: Shi Xiaomei , Ding Hongke , Li Chen , Liu Ling , Yu LiHua , Zhu Juan , wu jing 
Published: May 2022

Abstract
Objective: To evaluate the clinical utility of chromosomal microarray analysis (CMA) and whole exome sequencing (WES) in fetuses with oligohydramnios.Methods: In this retrospective study, 126 fetuses with oligohydramnios at our center from 2018 to 2021 were reviewed. Results of CMA and WES were analyzed.Results: One hundred and twenty-four cases had CMA performed and 32 cases had WES performed. The detection rate of pathogenic/likely pathogenic (P/LP) copy number variants (CNVs) by CMA was 1.6% (2/124). WES revealed P/LP variants in 21.8% (7/32) of fetuses. Six (85.7%, 6/7) fetuses showed an autosomal recessive inheritance pattern. Three (42.9%, 3/7) variants were involved in the renin-angiotensin-aldosterone system (RAAS), which are the known genetic causes of autosomal recessive renal tubular dysgenesis (ARRTD).Conclusion: CMA has low diagnostic utility for oligohydramnios. WES is an efficient approach and should be recommended in cases of oligohydramnios.
Reproductive performance of hair ewes and rams implanted with Melatonin previous to the anestrus season in Northwest Mexico
Authors: Leyva-Corona José Clemente , Angulo-Valenzuela Norberto Ismael , Laborin-Escalante Blanca Margarita , Gastelum-Delgado Miguel Angel , Silva-Ávila N. Jahzeel , Luna-Nevárez Pablo , Aragón-López Carlos Eduardo , Sánchez-Castro Miguel Angel , Pablos Marcela Ivone Morales 
Published: May 2022

Abstract
Ovine reproductive behavior depends on annual photoperiodic cycle and its impact on endogenous melatonin secretion. In this regard, exogenous melatonin administration previous to the physiological anestrus period could modify the reproductive performance of sheep. Two independent studies were performed to evaluate such hypothesis in hair sheep implanted with melatonin prior to the anestrus season in northwest Mexico. Study 1 involved 15 rams assigned to one of three treatments receiving 0mg (n=5), 18mg (n=5) or 36mg (n=5) of melatonin subcutaneously. Study variables were measured monthly since implantation (d0) and included testosterone concentration, scrotal circumference, mass motility, individual motility, and sperm concentration. Study 2 included 50 ewes assigned to one of two treatments receiving 0mg (n=25) or 18mg (n=25) of melatonin subcutaneously. In ewes, progesterone concentration and the frequency of females in anestrus were measured during the implantation (-30d), as well as at the beginning (0d) and at the end (45d) of the mating period, while pregnancy rate was determined by ultrasonography 45d after. Continuous variables were analyzed using a mixed effects model considering treatment, time, and the treatment by time interaction as fixed effects. Animal nested within treatment was the random effect. Binary variables were analyzed using the chi-square test. In males, melatonin improved testosterone and sperm concentrations (P&lt;0.05), while in females, a 28% higher pregnancy rate was observed in implanted ewes (P&lt;0.05). Although melatonin enhanced reproductive parameters in both sexes, its exogenous administration previous to the anestrus season in northwest Mexico could be more beneficial and cost effective in rams.
Functional genetic variants in circRNA regions associated with susceptibility and prognosis of prostate cancer
Authors: Cheng Yifei , Ben Shuai , Chen Silu , Zhao Lingyan , Shao Wei , Li Shuwei , Cheng Gong 
Published: May 2022

Abstract
Objective: To investigate the association of circRNAs and related genetic variants with PCa risk or prognosis. Methods: Using the MiOncoCirc database, we compared the expression of circRNAs between 25 matched PCa and adjacent normal tissues to identify risk-associated circRNAs. We also identified survival-associated circRNAs by comparing their expression between 35 castration-resistant PCa (CRPC) and 25 localized PCa tissues. We then used logistic regression and Cox proportional hazard models to evaluate the association of genetic variants in candidate circRNAs with PCa risk and prognosis based on the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, respectively. CircRNA-miRNA-mRNA interactions and RBPs of circRNAs were predicted through in silico analyses.Results: Rs11973492 on circHIBADH was a significant risk-associated variant (OR = 1.20, P = 7.06×10-4 in the dominant model). Furthermore, rs11679306 on circSATB2 was a survival-associated variant (HR = 1.32, P = 1.14×10-3 in the dominant model). CircHIBADH might sponge mir-107 thus regulating the expression levels of 29 mRNAs enriched in chemical carcinogenesis and other pathways, and could also bind several RPBs enriched in the RNA splicing pathway. Additionally, circSATB2 sponged mir-150-5p and regulated six mRNAs enriched in the extracellular matrix organization process.Conclusion: Our findings imply that genetic variants might affect the formation of circRNAs and influence the binding of circRNAs to miRNAs or RBPs, thus altering their biological functions in PCa oncogenesis and development.
Twelve-year changes in palm populations from a tropical lowland forest in the Philippines
Authors: Pasion Bonifacio O. , Duya Mariano Roy M. , Ong Perry S. , Fernando Edwino S. 
Published: May 2022

Abstract
Arecaceae (Palmae) is an ecologically and economically important family characteristic of the vegetation in tropical and subtropical regions, with at least 125 species occurring in the Philippines, most of them endemics. We monitored changes in stem density, mortality and recruitment of palm populations for twelve years within a 16-ha Forest Dynamic Plot located in northern Luzon, the Philippines. We recorded a total of 4,060 stems, dominated by Pinanga insignis (46%) and P. maculata (34%), followed by Caryota cumingii (19%), and a few stems (< 1%) of Orania decipiens and Areca whitfordii. Half (51%) of the initially recorded stems in the 2004 census died after the 2016 census, while an additional 1,086 (36%) stems were recorded in the same period. Overall palm population declined with the decreasing populations of P. insignis and P. maculata due to higher mortality than recruitment during the 2004–2010 and 2010–2016 census intervals while C. cumingii population increased in the same period. Regarding topographic position, the stem density of P. maculata is higher in valleys > midslopes > ridges across censuses, higher in valleys and midslopes than ridges for C. cumingii across censuses, and higher in midslopes than valleys for P. insignis during the 2016 census only. Mortality and recruitment were weakly observed along topographic positions between species and across censuses. Our result presents how palm population may change within twelve years with population trends differing between species, indicating the importance of palms in understanding the population dynamics of plant communities in a fast-changing environment.
Missense Variant rs34562254 of TNFRSF13B associated with HCV infection outcomes among Chinese Han Population
Authors: Fan Haozhi , Zhang Jinwei , Tan Weilong , Chen Qiong , Zeng Tian , Zhu Chuankong , Yue Ming 
Published: May 2022

Abstract
Background: In this study we investigated the relationship of tumor necrosis factor (TNF) superfamily (TNFSF) 13, and receptor superfamily (TNFRSF) 13B missense mutations with the susceptibility of HCV infection. Methods: Single nucleotide polymorphisms (SNPs) in TNFSF13 (rs3803800, rs11552708), and TNFRSF13B (rs34562254) were genotyped in 469 intravenous drug users, 728 hemodialysis patients and 1636 paid blood donors by TaqMan real-time PCR assay. Results: After adjustment for gender, age, ALT level, AST level and route of infection, the results of logistic regression analysis showed that the subjects carried rs34562254 TT mutant homozygous type in TNFRSF13B were more likely to be infected by HCV compared to those with rs34562254 CC wild homozygous type (additive model: OR = 1.21, 95% CI: 1.07-1.37, P = 0.002). And the effect of the risk allele (rs34562254-T) is more evident in female, elder (≥50), paid blood donors, lower ALT level (≤40 U/L) and lower ALT level (≤40 U/L) subgroup. The minimum free energy (MFE) of the centroid secondary structure for the mutant T allele of rs34562254 was higher than that of the wild C allele (-38.90 vs.-45.60 kcal/mol) with the RNAfold web servers. Conclusions: Taken together our study suggest that the missense variant rs34562254 were significantly associated with HCV infection by impacting host the TNFRSF13B gene transcription level among Chinese Han population.
Networks of international football: communities, evolution and globalization of the game
Authors: Li Yang , Mateos Gonzalo 
Published: May 2022

Abstract
As the most popular sport around the globe, the game of football has recently intrigued much research interest to explore and distill useful and appealing information from the sport. Network science and graph-centric methods have been previously applied to study the importance of football players and teams. In this paper, for the first time we study the macroscopic evolution of the football society from a complex network point of view. Football game records within a time window of over a century were collected and expressed in a graph format, where participant teams are represented by graph nodes and the games between them are the graph edges. We carry out community detection and temporal analysis to reveal the dynamic features and the community structures embedded within the football network, offering the evidence of a continuously expanding football society. Spatio-temporal analysis is also implemented to unveil the temporal states that represent distinct development stages in the football history. Our analysis suggests that the evolution of the game receives considerable impact not only from major sport events, but also from multiple social and political incidents. The game of football and its evolution reflect significant historical transitions and turning points, and can provide a novel perspective for the study of the worldwide globalization process.
Translationally controlled tumor protein restores memory and synaptic function lost in animal models of dementia
Authors: Na EunJung , Jeon Yejin , Kim Hyunju , Kim Hye-Sun , Lee Kyunglim , Kim Hwa-Jung 
Published: May 2022

Abstract
Background: The diverse roles of ubiquitously present translationally controlled tumor protein (TCTP) have been well delineated in several organs, but its possible function in the brain, especially with regard to memory function, has not received much attention. This study describes the effects of TCTP on mice with memory impaired by scopolamine (SCO) administration. Specifically, the memory and synaptic functions of 7- and 12-month-old SCO-treated wild mice (WT) were compared with those of TCTP-overexpressing (TG) and TCTP knocked down (KD) mice. Methods: Passive-avoidance tasks were performed on WT, TG and KD mice for 4 weeks after intraperitoneal injection with SCO (1 mg/kg) or saline (CON). After completion of the behavioral studies, the hippocampi were collected and their PSD-95, synapsin-1 and synaptophysin contents analyzed by western blocking and immunohistochemical analyses, and compared with those of 5xfamilial Alzheimer's disease (5xFAD) mice and postmortem AD patients. Results: The SCO-induced memory impairment was restored in TCTP-TG to that of WT level, but not in KD. Hippocampal expression of PSD-95, synapsin-1, and synaptophysin was increased in TG-SCO but decreased in KD-SCO mice. The decreased levels of TCTP, PSD-95, and synaptophysin were also found in the hippocampi of 5xFAD mice and AD patients. PSD-95 immunoreactivity increased particularly in dentate gyrus and CA1 in TCTP-TG, but reduced in KD. The p-CREB/CREB and brain-derived neurotrophic factor (BDNF) expressions also increased in TCTP-TG but dramatically decreased in KD. Conclusion: TCTP restores damaged memory in mice possibly by increasing synaptic function. Keywords TCTP, transgenic, knockdown, scopolamine-induced dementia, memory, synaptic function, PSD-95, synaptophysin, synapsin-1, CREB, BDNF
The function and possible mechanism of lncRNA LINC00881 in regulating fetal growth restriction
Authors: Tang Ranran , Yang Shanshan , Wen Juan , Zeng Yu , Jiang Hua 
Published: May 2022

Abstract
Background: Long noncoding RNAs (lncRNAs) were found to play important roles in the pathogenesis of FGR. Herein, we aimed to elucidate the role of LINC00881 in regulating various biological events of FGR.Methods: LINC00881 expression level was examined in the normal pregnancy placentas and FGR patients by quantitative reverse transcription PCR (qRT-PCR). The assays of CCK8, transwell and flow cytometry were performed to evaluate the functional effects of overexpression and silencing of LINC00881 on the HTR8/SVneo trophoblast cell line. RNA Pull down and immunoprecipitation (RIP) assays were futher used to verify the putative relationship between LINC00881 and its potential target of FSCN1.Findings: LINC00881 expression was signifcantly downregulated in 20 FGR placental tissues compared to 20 healthy placental tissues. LINC00881 overexpression promotes proliferation, migration, invasion and apoptosis of HTR8/SVneo trophoblast cell line in vitro. Downregulation of LINC00881 leads to the opposite results. RNA pull‑down assay and RIP assays reveals FSCN1 as a possible target of LINC00881. Futhermore, FSCN1 overexpression eliminated the effect of LINC00881 overexpression in HTR-8 cells.