bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the over-time, multifaceted impacts of three COVID-19 lockdowns on aspects of capability, wellbeing and mental health across vulnerabilities in Austria
Authors: Helter Timea M. , Łaszewska Agata , Simon Judit 
Published: October 2022

AbstractThe Austrian government imposed multiple major lockdowns during the COVID-19 pandemic, but the relevant measures and their perceptions varied over time. The aim of this study was to compare the over-time impacts of the three COVID-19 lockdowns between March 2020 and December 2021 for (capability) wellbeing and mental health in Austria. Adult Austrian residents (n = 87) completed an online survey about their experiences during three COVID-19 lockdowns, including capabilities (OxCAP-MH), depression and anxiety (HADS), and general wellbeing (WHO-5). Differences across the baseline and follow-up scores of these instruments were summarised by demographic/socioeconomic characteristics. Longitudinal comparisons of the impacts of the lockdowns were conducted using random effect models on panel data for overall instrument scores and individual capability items. The levels of (capability) wellbeing and mental health decreased for most respondents across the three lockdowns: average 2.4% reduction in OxCAP-MH scores, 18.8% and 9% increases in HADS depression and anxiety subscale scores respectively, and 19.7% reduction in WHO-5 score between the first and third lockdowns. Mental health treatment prior to the pandemic, social support and satisfaction with government measures were the most influential characteristics that determine the association with impacts of the chain of lockdowns. Our study is the first to assess the differential capability limiting aspects of lockdowns over time alongside their impacts on mental health and general wellbeing and calls for special attention for mental health patients, isolation and satisfaction with government measures.
Drug resistance and population structure of Plasmodium falciparum and Plasmodium vivax in the Peruvian Amazon
Authors: Villena Fredy E. , Sanchez Juan F. , Nolasco Oscar , Braga Greys , Ricopa Leonila , Barazorda Keare , Salas Carola J. , Lucas Carmen , Lizewski Stephen E. , Joya Christie A. , Gamboa Dionicia , Delgado-Ratto Christopher , Valdivia Hugo O. 
Published: October 2022

AbstractMalaria is a major health problem in Peru despite substantial progress achieved by the ongoing malaria elimination program. This study explored the population genetics of 63 Plasmodium falciparum and 170 P. vivax cases collected in the Peruvian Amazon Basin between 2015 and 2019. Microscopy and PCR were used for malaria detection and positive samples were genotyped at neutral and drug resistance-associated regions. The P. falciparum population exhibited a low nucleotide diversity (π = 0.02) whereas the P. vivax population presented a higher genetic diversity (π = 0.34). All P. falciparum samples (n = 63) carried chloroquine (CQ) resistant mutations on Pfcrt. Most P. falciparum samples (53 out of 54) carried sulfadoxine (SD) resistant mutations on Pfdhfr and Pfdhps. No evidence was found of artemisinin resistance mutations on kelch13. Population structure showed that a single cluster accounted for 93.4% of the P. falciparum samples whereas three clusters were found for P. vivax. Our study shows a low genetic diversity for both species with significant differences in genetic sub-structuring. The high prevalence of CQ-resistance mutations could be a result of indirect selection pressures driven by the P. vivax treatment scheme. These results could be useful for public health authorities to safeguard the progress that Peru has achieved towards malaria elimination.
Metabolic, physiological and anatomical responses of soybean plants under water deficit and high temperature condition
Authors: Vital Roberto Gomes , Müller Caroline , Freire Francisco Bruno Silva , Silva Fábia Barbosa , Batista Priscila Ferreira , Fuentes David , Rodrigues Arthur Almeida , Moura Luciana Minervina Freitas , Daloso Danilo Menezes , Silva Adinan Alves , Merchant Andrew , Costa Alan Carlos 
Published: October 2022

AbstractWater deficit (WD) combined with high temperature (HT) is the major factor limiting agriculture worldwide, and it is predicted to become worse according to the current climate change scenario. It is thus important to understand how current cultivated crops respond to these stress conditions. Here we investigated how four soybean cultivars respond to WD and HT isolated or in combination at metabolic, physiological, and anatomical levels. The WD + HT increased the level of stress in soybean plants when compared to plants under well-watered (WW), WD, or HT conditions. WD + HT exacerbates the increases in ascorbate peroxidase activity, which was associated with the greater photosynthetic rate in two cultivars under WD + HT. The metabolic responses to WD + HT diverge substantially from plants under WW, WD, or HT conditions.Myo-inositol and maltose were identified as WD + HT biomarkers and were connected to subnetworks composed of catalase, amino acids, and both root and leaf osmotic potentials. Correlation-based network analyses highlight that the network heterogeneity increased and a higher integration among metabolic, physiological, and morphological nodes is observed under stress conditions. Beyond unveiling biochemical and metabolic WD + HT biomarkers, our results collectively highlight that the mechanisms behind the acclimation to WD + HT cannot be understood by investigating WD or HT stress separately.
Visual odometry of Rhinecanthus aculeatus depends on the visual density of the environment
Authors: Karlsson Cecilia , Willis Jay , Patel Matishalin , de Perera Theresa Burt 
Published: October 2022

AbstractDistance travelled is a crucial metric that underpins an animal’s ability to navigate in the short-range. While there is extensive research on how terrestrial animals measure travel distance, it is unknown how animals navigating in aquatic environments estimate this metric. A common method used by land animals is to measure optic flow, where the speed of self-induced visual motion is integrated over the course of a journey. Whether freely-swimming aquatic animals also measure distance relative to a visual frame of reference is unclear. Using the marine fish Rhinecanthus aculeatus, we show that teleost fish can use visual motion information to estimate distance travelled. However, the underlying mechanism differs fundamentally from previously studied terrestrial animals. Humans and terrestrial invertebrates measure the total angular motion of visual features for odometry, a mechanism which does not vary with visual density. In contrast, the visual odometer used by Rhinecanthus acuelatus is strongly dependent on the visual density of the environment. Odometry in fish may therefore be mediated by a movement detection mechanism akin to the system underlying the optomotor response, a separate motion-detection mechanism used by both vertebrates and invertebrates for course and gaze stabilisation.
Protist impacts on marine cyanovirocell metabolism
Authors: Howard-Varona Cristina , Roux Simon , Bowen Benjamin P , Silva Leslie P , Lau Rebecca , Schwenck Sarah M , Schwartz Samuel , Woyke Tanja , Northen Trent , Sullivan Matthew B , Floge Sheri A 
Published: October 2022

Abstract
The fate of oceanic carbon and nutrients depends on interactions between viruses, prokaryotes, and unicellular eukaryotes (protists) in a highly interconnected planktonic food web. To date, few controlled mechanistic studies of these interactions exist, and where they do, they are largely pairwise, focusing either on viral infection (i.e., virocells) or protist predation. Here we studied population-level responses of Synechococcus cyanobacterial virocells (i.e., cyanovirocells) to the protist Oxyrrhis marina using transcriptomics, endo- and exo-metabolomics, photosynthetic efficiency measurements, and microscopy. Protist presence had no measurable impact on Synechococcus transcripts or endometabolites. The cyanovirocells alone had a smaller intracellular transcriptional and metabolic response than cyanovirocells co-cultured with protists, displaying known patterns of virus-mediated metabolic reprogramming while releasing diverse exometabolites during infection. When protists were added, several exometabolites disappeared, suggesting microbial consumption. In addition, the intracellular cyanovirocell impact was largest, with 4.5- and 10-fold more host transcripts and endometabolites, respectively, responding to protists, especially those involved in resource and energy production. Physiologically, photosynthetic efficiency also increased, and together with the transcriptomics and metabolomics findings suggest that cyanovirocell metabolic demand is highest when protists are present. These data illustrate cyanovirocell responses to protist presence that are not yet considered when linking microbial physiology to global-scale biogeochemical processes.
Stable phase‐centre horn antenna using 3D printed dielectric rod for aperture efficiency improvement of space‐fed antennas
Authors: Bagheri Mohammad Omid , Hassani Hamid Reza , Sebak Abdel Razik 
Published: October 2022

AbstractThe design strategy to stabilise the phase centre (PC) of the conventional horn antenna using a shaped dielectric rod is presented for aperture efficiency improvement of space‐fed antennas. In most practical horn antennas, PC location has significant variations with frequency leading to phase error loss and aperture efficiency reduction over the bandwidth of interest. To overcome this drawback, based on physical reasoning, shaped dielectric rods with appropriate excitation mode are designed and placed on the aperture of conventional rectangular and conical horn antennas. The simulation results show that using a shaped dielectric rod inside the horn antenna leads to a decrease in phase‐centre variations versus frequency without disturbing the radiation pattern and reflection coefficient. To investigate the performance, a conical corrugated horn antenna loaded by a conical tapered dielectric rod is used as a feed of the transmitarray antenna. Using a shaped dielectric rod fabricated by 3D printing technology, the PC variations of the proposed horn decrease from 1.06 λ to 0.08 λ over the X‐band (λ at 8 GHz). The measurement of the fabricated transmitarray antenna shows an improvement of maximum aperture efficiency from 55% to 64.7% at 10 GHz. The aperture efficiency bandwidth above 50% level is also increased from 1 to 2.2 GHz.
Joint optimisation of transmit beamspace and receive filter in frequency diversity array‐multi‐input multi‐output radar
Authors: Zhou Changlin , Wang Chunyang , Gong Jian , Tan Ming , Bao Lei , Liu Mingjie 
Published: October 2022

AbstractFrequency diversity array (FDA) radar provides more degrees of freedom and can generate range‐angle‐time‐dependent beampattern. Furthermore, based on the receiver's multi‐input multi‐output (MIMO) scheme, the frequency diversity array‐multi‐input multi‐output (FDA‐MIMO) radar can develop a range‐dependent but time‐independent beampattern. Taking advantage of this feature, this article improves the signal‐to‐interference‐plus‐noise ratio and the effective suppression of interference by jointly optimising the transmit beamspace and the receive filter. Since the optimisation problem is a non‐convex problem with constant energy constraints, we transform it into two convex subproblems with restrictions. The whole algorithm follows the alternate optimisation over receive filter and transmit beamspace. By simulating challenging scenarios, we confirmed the effectiveness and superiority of the method.
General versus Regional Anesthesia and Neonatal Data: A Propensity-Score-Matched Study
Authors: Cojocaru Liviu , Salvatori Cristiana , Sharon Amir , Seung Hyunuk , Nyman Katherine , Kodali Bhavani S. , Turan Ozhan M. 
Published: October 2022

Objective This study aimed to evaluate whether there is a difference in neonatal outcomes with general anesthesia (GA) versus regional anesthesia (RA) when induction of anesthesia to delivery time (IADT) is prolonged (≥10 minutes).
Study Design This is a retrospective case–control study that included cases from July 2014 until August 2020. We reviewed all singleton pregnancies delivered between 24 and 42 weeks of gestation with IADT ≥ 10 minutes. Urgent deliveries, those who received RA for labor pain management or started cesarean delivery under RA and converted to GA, as well as cases with fetal anomalies, were excluded. The propensity score (PS) matching method was performed using age, ethnicity/race, body mass index, gestational age at delivery, preexisting maternal comorbidities, and pregnancy complications. Analyses were performed with SAS software version 9.4.
Results During the study period, we identified 258 cases meeting inclusion criteria. After the PS matching was applied, the study sample was reduced to 60 cases in each group. The median IADT and uterine incision to delivery time were similar between groups (41.5 [30.5, 52] vs. 46 minutes [38, 53.5], p = 0.2 and 1.5 [1, 3] vs. 2 minutes [1, 3], respectively). There was no significant difference between groups with respect to arterial or venous cord pH (7.24 [7.21, 7.26] vs. 7.23 [7.2, 7.27], p = 0.7 and 7.29 [7.26, 7.33] vs. 7.3 [7.26, 7.33], p = 0.4, respectively). Nor were there any associations between maternal characteristics and Apgar's score at 5 minutes, except for Apgar's score at 1 minute (p < 0.001). No significant difference was identified in the rate of admission to the neonatal intensive care unit (NICU; 11 [52.4%] vs. 10 [47.6%], p = 0.8) or NICU length of stay between GA and RA (4 [3, 14] vs. 4.5 [3, 11], p = 0.9).
Conclusion Our data indicate that even with prolonged IADT, favorable neonatal outcomes are seen with both GA and RA, in contrast with previous studies performed decades ago.
Key Points
Social Frailty in Late Adulthood: Social Cognitive and Psychological Well-Being Correlates
Authors: Henry Julie D , Coundouris Sarah P , Mead Jessica , Thompson Brielle , Hubbard Ruth E , Grainger Sarah A 
Published: October 2022

Abstract

Objectives
Social frailty poses a major threat to successful aging, but its social cognitive and psychological well-being correlates remain poorly understood. This cross-sectional study provides initial insights into whether social cognitive difficulties in older age are associated with social frailty, as well as how social frailty is linked to psychological characteristics known to be important for health and well-being.

Method
Ninety community-dwelling older adults completed measures of social frailty and social cognition (social perception, theory of mind, affective empathy, and informant-rated social behavior) as well as measures of psychological function known to be important for health and well-being, both positively (resilience and life satisfaction) and negatively (demoralization, social anxiety, and apathy). Measures of cognitive frailty, physical frailty, and depression were also administered to test the specificity of any observed relationships with social frailty.

Results
Both affective empathy and social behavior were predictive of increased social frailty, but social behavior emerged as the only unique predictor after controlling for covariates. Social frailty also predicted unique variance in all five measures of psychological well-being, and for three of these measures (demoralization, resilience, and life satisfaction), the effects remained significant even after adjusting for covariates.

Discussion
Findings are discussed in relation to models of socioemotional aging and frailty. Potential mechanisms linking social behavior to social capital in older age are identified, as well as how loss of social resources might both directly and indirectly impact well-being.
Receptive Language Abilities for Females Exposed to Early Life Adversity: Modification by Epigenetic Age Acceleration at Midlife in a 30-Year Prospective Cohort Study
Authors: Felt John M , Harrington Karra D , Ram Nilam , O’Donnell Kieran J , Sliwinski Martin J , Benson Lizbeth , Zhang Zhenyu , Meaney Michael J , Putnam Frank W , Noll Jennie G , Shenk Chad E 
Published: October 2022

AbstractObjectivesDeviations from normative trajectories of receptive language abilities following early life adversity (ELA) may indicate an elevated risk for advanced cognitive aging and related morbidities. Accelerated epigenetic aging at midlife may further identify those at greatest risk for advanced cognitive aging following ELA. We examined whether accelerations in epigenetic aging at midlife can identify those individuals who demonstrated the greatest change in receptive language abilities following ELA.MethodsData were drawn from the Female Growth and Development Study (n = 86), a 30-year prospective cohort study of females exposed to substantiated child sexual abuse (CSA), a severe ELA, and a non-CSA comparison condition. The Peabody Picture Vocabulary Test-Revised (PPVT-R) measured receptive language abilities on 6 occasions from childhood to mid-life. Interindividual differences in PPVT-R trajectories were examined in relation to CSA exposure and across 5 independent measures of epigenetic age acceleration derived from first (Horvath DNAmAge, Hannum DNAmAge) and second (GrimAge, PhenoAge, Dunedin Pace of Aging) generation epigenetic clocks.ResultsQuadratic growth models revealed that PPVT-R scores were significantly lower at age 25 for females exposed to CSA. Specifically, CSA exposed females had lower intercepts when GrimAge was accelerated and a smaller quadratic trend when PhenoAge was accelerated. DiscussionELA is associated with significant differences in development of receptive language abilities with the most pronounced differences observed for females with accelerated epigenetic ages at mid-life. These findings suggest that epigenetic age acceleration could serve as an indicator of differences in cognitive aging and portend to later adulthood cognitive functioning.
Musical Exdurantism
Authors: Letts Philip 
Published: October 2022

AbstractRecently, Caterina Moruzzi has appealed to Ted Sider’s case for continuant exdurantism and the availability of a “parallel move” in musical ontology to promote a specific version of musical work exdurantism. In this article, I argue that her version of musical exdurantism undermines the prospects for making the parallel move, but I go on to sketch two alternatives that do not. In Section I, I outline apparent persistence-parallels between ordinary material objects and musical works. In Section II, I sketch a transposable case for accepting continuant exdurantism. In Section III, I introduce Moruzzi’s exdurantism. In Section IV, I introduce her selected rivals—the type-token theory of Julian Dodd and an austere musical perdurantism due to Ben Caplan and Carl Matheson. In Section V, I argue that several of Moruzzi’s commitments undermine her motivation from the “parallel move.” In sections VI and VII, I sketch alternative versions of musical exdurantism that are better positioned to adopt the parallel move.
Effect of live yeast supplementation on energy partitioning and ruminal fermentation characteristics of steers fed a grower-type diet in heat-stress conditions
Authors: D’Souza Genevieve M , Dias Batista Luiz Fernando , Norris Aaron B , Tedeschi Luis O 
Published: October 2022

Abstract
The objective of this trial was to determine the influence of live yeast supplementation (LY), environmental condition (ENV), and their interaction (TRT) on energy partitioning, nitrogen metabolism, and ruminal fermentation dynamics of steers receiving a grower-type diet. The effects of LY and ENV were investigated using a 2 × 2 crossover design that spanned five periods. Eight Angus-crossbred steers were randomly split into pairs and housed in four outdoor pens outfitted with an individualized feeding system. Animals were limit-fed a grower diet (DIET) at 1.2% shrunk body weight (SBW) with no live yeast supplementation (NOY) or a grower diet top-dressed with 10 g LY/d for 14 d (1.2 × 1012 CFU/d). On days 13 and 14, animals were subjected to one of two ENV conditions, thermoneutral (TN; 18.4 ± 1.1 °C, 57.6 ± 2.8% relative humidity [RH]) or heat stress (HS; 33.8 ± 0.6 °C, 55.7 ± 2.7% RH), in two side-by-side, single-stall open-circuit, indirect respiration calorimetry chambers. Data were analyzed using a random coefficients model. Carryover effects were examined and removed from the model if not significant. Gross (GE), digestible, metabolizable, heat, and retained energies were not influenced by DIET, ENV, or TRT (P ≥ 0.202). Gaseous energy, as a percentage of GE, tended to increase during HS (P = 0.097). The only carryover effect in the study was for oxygen consumption (P = 0.031), which could be attributed to the tendency of NOY (P = 0.068) to have greater oxygen consumption. DIET, ENV, or TRT (P ≥ 0.154) had no effects on total animal methane or carbon dioxide emissions. Similarly, DIET, ENV, or TRT (P ≥ 0.157) did not affect ruminal pH, redox, protozoa enumeration, ruminal ammonia concentrations, and acetate-to-propionate ratio. Propionate concentrations were the greatest in animals in TN conditions receiving LY (P = 0.034) compared to the other TRT. This effect is mirrored by TN-LY tending to have greater acetate concentrations (P = 0.076) and total VFA concentrations (P = 0.065). Butyrate concentrations tended to be greater for animals fed LY (P = 0.09). There was a tendency for LY to have elevated numbers of Fusobacterium necrophorum (P = 0.053). Although this study lacked effects of LY on energy partitioning, nitrogen metabolism, and some ruminal parameters during HS, further research should be completed to understand if LY is a plausible mitigation technique to enhance beef animals’ performance in tropical and sub-tropical regions of the world.
Alginate Dressings Continuously for 14 Days on Uncontaminated, Superficial, Partial Thickness Burns
Authors: Stynes Gil , Haertsch Peter , O’Hara Justine , Knight Robert , Issler-Fisher Andrea C , Maitz Peter K M 
Published: October 2022

Abstract
Calcium alginate dressings are commonly used on split-thickness skin donor sites, where they are typically removed after 14 days. Alginates have been used previously on superficial, partial thickness burns, but changed every 3 to 5 days. In this study, alginates were applied to superficial, partial thickness burns on adults within 36 hours of injury, then left intact for up to 14 days. Wound healing (≥95% wound epithelialization) and pain were measured. Twenty-one burns were reviewed on ten patients. Per the initial protocol, six patients were reviewed every 3 to 5 days, with removal of only secondary dressings, until days 13 to 14, when the alginate dressings were removed. One patient was reviewed every 3 to 5 days until day 10, when a clinic nurse removed the alginate dressing. Restrictions on movement during the COVID pandemic necessitated a protocol change, with only one review at approximately day 14 for removal of alginate and secondary dressings; three patients were reviewed in this manner. Burns on all patients were 100% epithelialized at the time of final review and there were no complications, such as scarring, infection, or need for grafting. Following initial debridement and dressings, patients reported minimal pain. Dressing costs appeared to be significantly decreased. This protocol may be particularly useful for patients managed in rural and remote locations, with telemedicine support if required.