bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Development of a Proof-of-Concept Physician-Driven Informatics Consult System for the Individualized Treatment of Patients with Orthopaedic Conditions
Authors: Singh Akanksha , Schooley Benjamin , Lindros Sydney H. , Brooks John M. , Kissenberth Michael , Pill Stephan , Faucher Gregory , Daly Charles , Jeray Kyle , Floyd Sarah B. 
Published: October 2022

Abstract
Background: The diversity and variation of patient data now increasingly documented in Electronic Health Record (EHR) systems can be used to generate evidence about which treatments work and for whom they work. The objective of this work was to demonstrate proof-of-concept of a physician-driven informatics consult system which can drive improvements in the quality and safety of orthopaedic care. The informatics consult system allows for physicians to perform dynamic searches and receive immediate data summaries of similar, previously treated patients at the point of care. As a first use case, we apply our informatics consult prototype to the treatment of acute proximal humerus fractures (PHF).
Methods: We used an EHR-based, simulated patient data file to develop the informatics consult system prototype, ICSCEDIT (Informatics Consult System for Comparative Effectiveness Data for Individualized Treatment). We developed a user interface for physicians to define similar patient groups or reference classes, and we use comparative effectiveness research methodology and visual analytics to summarize outcomes for patients under treatment alternatives. Candidate wireframes were reviewed by the research and clinical team members in iterative user experience phases, each phase employing 1) prototype design and demonstration, 2) collection and documentation of expert/user feedback, and 3) prototype redesign based on feedback.
Results: ICSCEDIT was designed with a series of patient characteristic filters that can be applied to subset historical patient records into similar cohorts matching the index patient of interest. A total of 14 patient filters across demographic, fracture characteristics, and patient comorbidities are included. The evidence for patient reference classes, displayed by treatment group, appears in a series of three tabs. The first tab displays treatment rates of initial surgery and conservative management for the reference class. The second tab contains summaries of patient-reported outcome measures presented by treatment group and the third tab displays summaries of healthcare utilization over the year following the PHF injury.
Conclusion: We describe a prototype of an informatics consult system for orthopaedic medicine. Informatics consult systems that enable learning from historical treatment decisions and outcomes holds great potential for improving the quality of care for all orthopaedic patients.
A method of predicting the magnitude and failure time of a
Authors: WANG JEEN-HWA 
Published: October 2022

Abstract
Let T and M be, respectively, the precursor time of a certain precursor and the magnitude of a forthcoming earthquake. Observations may lead to a relationship of T versus M in a form of log(T)=a+bM. In this study, we will explore the physical basis of the relationship. Based on the log(T)−M relationships of two different precursors, we propose a method to predict the magnitude and failure time of the forthcoming earthquake. A testing example based on the log(T)−M relationships of presiemic radon concentration anomalies and gamma-ray emission changes observed at respective monitoring stations in Taiwan is given in this study. Results strongly confirm a high possibility of predicting the magnitude and failure time of a forthcoming earthquake just from the observed occurrence times of two different precursors based on their log(T)−M relationships.
Regional terrain-based VS30 prediction models for China
Authors: Zhang Yuting , Ren Yefei , Wen Ruizhi , Wang Hongwei , Ji Kun 
Published: October 2022

Abstract
Time-averaged shear-wave velocity to 30 m (VS30) is commonly used in ground motion models as a parameter for evaluating site effects. This study used a collection of boreholes in Beijing, Tianjin, Guangxi, Guangdong, and three other municipalities and provinces, which were divided into three regions with reference to the seismic ground motion parameter zonation map of China, to establish VS30 prediction models based on terrain categories. Regional effects were verified by comparing morphometric parameters (topographic slope, surface texture, and local convexity) thresholds and terrain classification maps obtained from the global digital elevation model (DEM) data and the regional DEM data of the three regions. Additionally, VS30 prediction models for the three regions using both types of terrain classification maps were established and analyzed comparatively to provide credible regional VS30 models for China. Through analysis of the correlations between the measured VS30 values and the predicted VS30 values, and with consideration of the geological characteristics of the boreholes, the VS30 prediction models based on terrain classification maps from regional data were finally applied in developing regional VS30 models for China. Intercomparison of the VS30 prediction models for the three regions indicated that subregional consideration is necessary in terrain classification. Finally, a spatial analysis method adopting inverse distance weighting of the residuals was used to update the initial VS30 models. The developed VS30 models could be used both in developing regional ground motion models and in the construction of earthquake disaster scenarios.
Mechanisms of the DNA Damage Repair Gene Work on Elevated α/β ratio after Hypofractionated Radiotherapy for Prostate Cancer
Authors: Cui Ming , Chen Qiong , Gao Xianshu , Sun Deyu 
Published: October 2022

Abstract
Purpose: Our previous study showed that the linear quadratic (LQ) model appeared to be inappropriate for high doses per fraction owing to α/β ratio tending to become higher when the dose per fraction increased. In order to verify this conclusion, we explored the mechanisms for the elevated α/β ratio after hypofractionated radiotherapy.
Materials and Methods: We selected two prostate cancer cell lines DU145 and PC3:
1) Draw the cell survival curve to calculate the α/β ratio, and then use biological effective dose (BED) formula to convert fractionated radiation dose into equivalent single hypofractionated radiation dose (calculated values) comparing with that on the survival curve (actual values).
2) Western Blot and laser confocal immunofluorescence were used to detect the expression of γ-H2AX and RAD51 after different fractionated modes of radiation at different time points.
Results:
1) When fractionated radiation dose was converted into equivalent single hypofractionated radiation dose, the ability of hypofractionated radiation was overestimated. If a larger α/β ratio is used, the discrepancy tended to become smaller.
2) Compared with fractionated radiation, the results showed that the expression of γ-H2AX was higher after 30min, 6 h and 24h after single hypofractionated radiation. Meanwhile, the expression of RAD51 lasted for 24 hours and the DNA damage still existed in single hypofractionated radiation.
3) The results also showed that the expression of γ-H2AX decreased slightly after 24 hours of fractionated radiation compared with that of 6 hours, and there was no difference in single hypofractionated radiation between 6 hours and 24 hours.
Conclusions: The results of this study suggest that after single hypofractionated radiation, the irreparable damage in cells increased (that is, α value increased), and some repairable sublethal damage (β value) was converted into irreparable damage (α value). When α value increased and β value decreased, the ratio increased.
Does Progesterone Affect Perioperative Blood Loss during Posterior Spinal Fusion Surgeries in Female Patients with Adolescent Idiopathic Scoliosis?: a retrospective study
Authors: Jiao Yang , Tan Haining , Wang Zhen , Zhao Junduo , Shen Jianxiong 
Published: October 2022

Abstract
Background: Menstruation is considered a contraindication for elective surgery for higher operative blood loss. Progesterone is often used to postpone menstruation to avoid surgery during menstruation. This study aimed to explore whether using progesterone to postpone menstruation affects perioperative blood loss in female patients with adolescent idiopathic scoliosis (AIS) who underwent posterior spinal fusion (PSF) surgery.
Methods: A retrospective study was performed for female patients diagnosed with AIS who underwent PSF surgery between March 2013 and January 2021. Patients with irregular menstruation or before menarche,who used tranexamic acid, who underwent Schwab grade III–VI osteotomywere excluded. Patients scheduled to undergo PSF surgery from 2 days before menstruation to 3 days after menstruation were treated with progesterone preoperatively. The patients were divided into two groups according to progesterone use (group A, progesterone injection group; group B, control group). Demographic and surgical data including intraoperative blood loss (IBL), normalized blood loss (NBL), total blood loss (TBL), transfusion rate, perioperative complications, postoperative hospital stay,and preoperative coagulation function data.
Results:Group A included 41 patients, while group B included 165. The two groups were matched for age, height, weight, operation time, Risser sign, correction rate, mean curve Cobb angle, bending Cobb angle, and number of internal fixations, number of fused levels (all P >0.05). Regarding coagulation function, no significant difference was found between thrombin time, activated partial thromboplastin time, fibrinogen, prothrombin time and platelet count. IBL, NBL and TBL were higher in group A; however, the difference was nonsignificant. Transfusion rate, perioperative complications, and postoperative hospital stay were not statistically different between groups.
Conclusion: Intramuscular injection of progesterone to postpone menstruation did not affect perioperative blood loss in female AIS patients who underwent PSF surgery. Furthermore, it did not increase the incidence of perioperative complications or prolong postoperative hospital stay. Therefore, it may be a safe method for AIS patients to undergo PSF surgery as scheduled.
Phytoglycogen-dsRNA nanoparticles demonstrate differential cytotoxicity and immunostimulatory potential in two ovarian cancer cell lines
Authors: Lewis A. , Tran A. , Aldor N.L. , Jadaa N. , Feng T. , Moore E. , DeWitte-Orr S.J. , Poynter S.J. 
Published: October 2022

AbstractBackground Ovarian cancer is a leading cause of cancer mortality in women, and only a small percentage of cases are caught at an early stage. Novel treatments with improved efficacy are needed to fight ovarian cancer and to overcome resistance to traditional therapies. Double-stranded (ds) RNA, including the synthetic polyinosinic cytidylic acid (poly (I:C), has shown promise as a cancer therapeutic. Two ovarian cancer cell lines were tested for their ability to produce an immune response to poly (I:C) delivered using a nanoparticle carrier, a biodegradable phytoglycogen derived from sweet corn, called nanodendrix (NDX). SKOV-3 and OVCAR-3 have been previously identified as dsRNA-resistant and dsRNA-sensitive, respectively. Results Firstly, NDX was found to effectively bind poly (I:C), at a w/w ratio of 2:1 NDX:poly (I:C), the resulting particles, poly (I:C)-NDX, were tested for biological activity through uptake and two therapeutic modes of action, cytotoxicity and stimulation of the innate immune response. Both cell lines bound poly (I:C)-NDX, as observed using immunocytochemistry. In OVCAR-3 poly (I:C)-NDX caused significant cell death, even at concentrations as low as 62.5ng/mL, measured using the cell viability indicator dye alamarBlue; no cell death was observed with poly (I:C) alone across all concentrations, up to 5µg/mL in SKOV-3 and 0.5µg/mL in OVCAR-3. In both OVCAR-3 and SKOV-3, poly (I:C)-NDX stimulated the production of an innate immune chemokine, CXCL10, at the transcript and protein levels, at significantly higher levels than poly (I:C) alone. Interestingly, in response to poly (I:C)-NDX SKOV-3 produced a more robust immune response compared and higher levels of capase-3/-7 activation compared to OVCAR-3, despite showing no significant cell death. Conclusions Poly (I:C)-NDX represents a robust and multifunctional therapy with demonstrated efficacy against a range of ovarian tumour cells, potentiating poly (I:C) and sensitizing resistant cells. Additionally, the SKOV-3 and OVCAR-3 combination represents a powerful comparative model to help unravel dsRNA-mediated immune responses in ovarian cancer cells.
Durable Queries over Non-synchronized Temporal Data
Authors: Xie Yanqi , Weng Wei , Li Jianmin 
Published: October 2022

Abstract
Temporal data are ubiquitous nowadays and efficient management of temporal data is of key importance. A temporal data typically describes the evolution of an object over time. One of the most useful queries over temporal data are the durable top-k queries. Given a time window, a durable top-k query finds the objects that are frequently among the best. Existing solutions to durable top-k queries assume that all temporal data are sampled at the same time points (i.e., at any time, there is a corresponding observed value for every temporal data). However, in many practical applications, temporal data are collected from multiple data sources with different sampling rates. In this light, we investigate the efficient processing of durable top-k queries over temporal data with different sampling rates.We propose an efficient sweep line algorithm to process durable top-k queries over non-synchronized temporal data. We conduct extensive experiments on two real datasets to test the performance of our proposed method. The results show that our methods outperforms the baseline solutions by a large margin.
Fragmented understanding: exploring the practice and meaning of informed consent in clinical trials in Ho Chi Minh City, Vietnam
Authors: Nguyen Yen Hong Thi , Dang Thuan Trong , Lam Ngoc Bao Hong , Le Phuong Thanh , Nguyen Phu Hoan , Bull Susan , Kestelyn Evelyne , Nuil Jennifer Ilo van 
Published: October 2022

Abstract

Background
The informed consent process in clinical trials has been extensively studied to inform the development processes which protect research participants and encourage their autonomy. However, ensuring a meaningful informed consent process is still of great concern in many research settings due to its complexity in practice and interwined socio-cultural factors.
Objectives
This study explored the practices and meaning of the informed consent process in two clinial trials conducted by Oxford University Clinical Research Unit in collaboration with the Hospital for Tropical Diseases in Ho Chi Minh City, Vietnam.
Methods
We used multiple data collection methods including direct observervations, in-depth interviews with study physicians and trial participants, review of informed consent documents from 2009 to 2018, and participant observation with patients’ family members. We recruited seven physicians and twenty-five trial participants into the study, of whom five physicians and thirteen trial participants completed in-depth interviews, and we held twenty-two direct observation sessions.
Results
We use the concept “fragmented understanding” to describe the nuances of understanding about the consent process and unpack underlying reasons for differing understandings.
Conclusions
Our findings show how practices of informed consent and fragemented understanding are shaped by trial participants’ characteristics and the socio-cultural context in which the trials take place.
HBV genotype-dependent association of HLA Variants with the Serodecline of HBsAg in Chronic Hepatitis B Patients: a 14-year Follow-up Study
Authors: Chu Yu-Ju , Yang Hwai-I , Hu Hui-Han , Liu Jessica , Lin Yu-Ling , Chang Chia-Ling , Luo Wen-Sheng , Jen Chin-Lan , Chen Chien-Jen 
Published: October 2022

Abstract
Background and Aims Seroclearance of hepatitis B surface antigen (HBsAg) is regarded as the functional cure of chronic hepatitis B (CHB). The relationship between human leukocyte antigen (HLA) variants, hepatitis B virus genotype, and longitudinal HBsAg serodecline remains to be explored.
Methods A total of 2498 HBeAg-seronegative CHB patients of the community-based REVEAL-HBV cohort were genotyped for rs1710 (HLA-G) and rs2770 (HLA-B) using TaqMan assay. Cox proportional hazard regression and generalized linear mixed models were used to analyze the association of HLA genetic variants with the rate of HBsAg seroclearance and longitudinal HBsAg serodecline.
Results Rs1710 G allele was differentially associated with the HBsAg seroclearance in genotype B [aRR (95% CI)=0.74 (0.56-0.98)] and genotype C [aRR (95%CI)=1.43 (1.08-1.88)] infection. Rs2770 G allele was associated with HBsAg seroclearance only in genotype B infection [aRR (95% CI)=0.69 (0.52-0.91)]. The alleles associated with HBsAg seroclearance were significant predictors for the serodecline of HBsAg levels in an HBV genotype-dependent manner (genotype B infection: rs1710, p=0.013; rs2770, p=0.0081; genotype C infection: rs1710, P=0.0452).
Conclusions Our results suggest both spontaneous HBsAg seroclearance and serodecline are modified by the interaction between HLA variants and HBV genotype.
Imaging-based 3D Particle Tracking System for Field Characterization of Particle Dynamics in Atmospheric Flows
Authors: Bristow Nathaniel , Li Jiaqi , Hartford Peter , Guala Michel , Hong Jiarong 
Published: October 2022

Abstract
A particle tracking velocimetry apparatus is presented that is capable of measuring three-dimensional particle trajectories across large volumes, of the order of several meters, during natural snowfall events. Field experiments, aimed at understanding snow settling kinematics in atmospheric flows, were conducted during the 2021/2022 winter season using this apparatus, from which we show preliminary results. An overview of the methodology, wherein we use a UAV-based calibration method, is provided, and analysis is conducted of a select dataset to demonstrate the capabilities of the system for studying inertial particle dynamics in atmospheric flows. A modular camera array is used, designed specifically for handling the challenges of field deployment during snowfall. This imaging system is calibrated using synchronized imaging of a UAV-carried target to enable measurements centered 10 m above the ground within approximately a 4 m x 4 m x 6 m volume. Using the measured Lagrangian particle tracks we present data concerning 3D trajectory curvature and acceleration statistics, as well as clustering behavior using Voronoi analysis. The limitations, as well as potential future developments, of such a system are discussed in the context of applications with other inertial particles.
Fabrication of cadmium-based imidazole zeolite nanostructure for the adsorption of Sunset Yellow dye from aqueous solution
Authors: Sarpiri Ahad Mirahmadi , Soltanolkottabi Fariba 
Published: October 2022

Abstract
Zeolitic-imidazole framework Cd-ZIF was synthesized and characterized. The synthesized zeolite was used in the sunset yellow (SY) adsorption. Impact of different variables on batch method as a function of solution pH, concentration of SY, dose of Cd-ZIF, contact time and temperature were analyzed and optimal conditions were determined. The point of the zeolite zero charge (pHPZC) was obtained 7.0. Langmuir and Freundlich models were employed by equilibrium data from SY adsorption process. The results showed that Freundlich model was fitted. The kinetics of adsorption indicated that SY adsorption followed pseudo-second-order model and chemisorption.
Temperament and Home Environment Affect ADHD and Internalizing in Preschoolers
Authors: Jamnik Matthew R. , Nethala Vijay Sam , DiLalla Lisabeth F. 
Published: October 2022

Abstract
Increasing prevalence of children’s attention-deficit/hyperactivity disorder (ADHD) and internalizing behaviors requires investigation into putative risk factors. This longitudinal project of 105 preschoolers examined influences of early life experiences (perinatal stressors, home environment) and individual differences (child temperament) on problem behaviors. Results demonstrated differences predicting to ADHD versus internalizing behaviors. Higher 5-year-old ADHD behavior was predicted by higher age 4 temperamental activity and a significant interaction between observed activity and temperamental effortful control. For children with low effortful control, higher age 4 observed activity corresponded with elevated 5-year-old ADHD behaviors. Conversely, for children in low chaos homes, greater age 4 temperamental activity significantly predicted fewer 5-year-old internalizing behaviors. These differential associations among preschoolers’ activity levels predicting to ADHD versus internalizing behaviors suggest that greater activity levels may be a risk for some children (e.g., low effortful control) but a protective factor for others (e.g., low household chaos). Clinical implications are discussed.
WITHDRAWN: Microplastic accumulation in aquatic insects of different feeding guilds collected from wastewater in Sohag Governorate, Egypt
Authors: Khdre Azza M. , Ramadan Somaia A. , Ashry Ali , Alaraby Mohamed 
Published: October 2022

Abstract
Microplastics (MPs) have been detected in many freshwater organisms because of increasing plastic contamination within the freshwater environment. However, the correlation between MPs in organisms and their surrounding environment still needs studies. This study investigates MP contamination in one of the wastewater ponds east of Sohag Governorate, Egypt. Four common freshwater insect families representing different feeding guilds were employed to detect MPs contamination. The collector-gatherer (Chironomidae, Chironomus sp.) recorded the highest MP load per gram wet weight. However, predators (Aeshnidae, Aeshna sp.) recorded the lowest one. A reverse trend was observed based on MP load per individual. Polyester fibers were the most common type of MPs followed by fragments (Polyethylene and polypropylene) in both sediment and water. However, only polyester fibers were found in the different insect taxa. The blue color was the predominant color in the water, sediment, and insect fauna. The mean length of fibers in the different insects was a little smaller than those in the surrounding environment. The presence of MPs in some examined insects (lower trophic levels) gives a possibility of transferring to higher levels following predation. Therefore, further studies should be carried out along different feeding groups of higher levels to detect the potential risk of MPs on different freshwater fauna.
Deploying Vaccine Distribution Sites for Improved Accessibility and Equity to Support Pandemic Response
Authors: Li George Zhaoqi , Li Ann , Marathe Madhav , Sriniva Aravind , Tsepenekas Leonidas , Vullikanti Anil 
Published: October 2022

Abstract
In response to COVID-19, many countries have mandated social distancing and banned large group gatherings in order to slow down the spread of SARS-CoV-2. These social interventions along with vaccines remain the best way forward to reduce the spread of SARS CoV-2. In order to increase vaccine accessibility, states such as Virginia have deployed mobile vaccination centers to distribute vaccines across the state. When choosing where to place these sites, there are two important factors to take into account: accessibility and equity. We formulate a combinatorial problem that captures these factors and then develop efficient algorithms with theoretical guarantees on both of these aspects. Furthermore, we study the inherent hardness of the problem, and demonstrate strong impossibility results. Finally, we run computational experiments on real-world data to show the efficacy of our methods.