bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Diagnosis, disclosure and stigma: The perspectives of Indonesian children with HIV and their families’
Authors: Qur’aniati Nuzul , Sweet Linda , De Bellis Anita , Hutton Alison 
Published: October 2022

This grounded theory study aimed to explore the subjective experiences of children living with Human Immunodeficiency Virus (HIV) from the perspective of children and their families in Indonesia. Twenty participants were interviewed, consisting of 12 children aged 9–18 years and eight family members. Using grounded theory analysis, this study identified three categories: ‘coping with diagnosis’, ‘disclosing their status’ and ‘living with the stigma of HIV’. Participants responded with shock, denial, sadness, secrecy and often had misconceptions about the virus to the diagnosis of themselves or their children. After diagnosis, children with HIV and their families continuously lived with stigma stemming from individual and societal beliefs about the virus. This stigma manifested in actions such as isolation, disclosure avoidance, secrecy, deception and social rejection. Because of these stigmatisations, many of the participants decided not to disclose the child’s HIV status and used status strategies such as telling lies, keeping secrets and keeping their distance. The participants offered insight into the need for comprehensive programs to address care gaps. This study highlights that health professionals need to develop practical guidelines to support families during the disclosure process, provide psychosocial care for children, and create stigma reduction interventions for children with HIV.
Reduction of noise generated by cylinder-airfoil interaction using grooved structures on the upstream cylinder
Authors: Zhang Chengchun , Sun Xiaowei , Du Tianyu , Shen Chun , Chen Zhengwu , Liang Dong , Zhao Jiale , Zhang Yingchao 
Published: October 2022

The cylinder-airfoil interaction noise can be reduced by changing the shape of the leading edge of the downstream airfoil. Generally, this way not only can reduce the interaction noise at middle and high frequency, but also can change the peak noise at the low frequency. This study attempts to affect the cylinder-airfoil interaction noise from the perspective of reducing the intensity of the upstream wake shedding vortex. In order to achieve this target, the equally spaced grooves were cut into the upstream cylinder, and the acoustic wind tunnel tests at various incoming velocities (20–60m·s−1) were conducted to compare the interaction noise of cylinder-airfoil (NACA0012) models. It is found that the grooved structure can effectively reduce the peak noise at characteristic frequencies bellow 1000 Hz and the broadband noise in the mid-frequency ranging from 1000 Hz to 3000 Hz, especially for the higher incoming velocity. Thereinto, the peak noise and overall sound pressure level (OASPL) with the grooved cylinder are reduced by 13 dB and 7.2 dB, respectively at the incoming velocity of 60 m·s−1. The numerical simulations based on the large eddy simulation (LES) and Ffowcs Williams–Hawkings (FW-H) acoustic analogy were performed to further reveal the mechanisms of noise reduction when the velocity is 60 m·s−1. The results show that the vortex shedding from cylinder wake is suppressed by the grooved cylinder and the vortex structure at the leading edge of the airfoil is also cut into the small-scale vortex structures by the grooved structure. The pressure fluctuation amplitude and the peak value turbulent kinetic energy in the wake of the grooved cylinder are significantly reduced. In addition, the further spectrum analysis reveals that the weak correlation of the vortex shedding on the grooved cylinder could lead to the suppression of the pressure fluctuation in the cylinder wake, and thereby the interaction noise is significantly reduced.
Effects of Acupuncture on Cancer Pain in Animal Intervention Studies: A Systematic Review and Quality Assessment
Authors: Jiao Liangbo , He Xiaoxia , Zhang Jihong , Liu Yali , Luo Yanan , Wei Hu 
Published: October 2022

Background: Preclinical studies often provide the evidence base for clinical studies. However, the design and reporting of preclinical trial results are inadequate, resulting in poor reproducibility and clinical translatability. We aimed to systematically evaluate the methodology and reporting quality of animal studies of acupuncture for cancer pain. Methods: About 7 databases were searched for animal research articles on acupuncture for cancer pain from the beginning of the database to January 31, 2022. ARRIVE guidelines, STRICTA, and SYRCLE risk of bias tools were used to assess the reporting quality and risk of bias of the selected studies. Results: A total of 18 studies were evaluated. Of the 22 items on the SYRCLE tool, only 6 items had a positive reporting rate of more than 50%. Of the 39 items in the ARRIVE guidelines, 14 were rated excellent, and the least frequently reported checklist items were 7. Out of the 17 STRICTA checklist items analyzed, 10 were considered appropriately reported in more than 80% of the studies, while 4 were correctly reported in less than 20%. Conclusions: Some crucial points in the design, implementation, and reporting of the experiments included in the study were not well developed, which could significantly affect the clarity, reproducibility, and translatability of the experiments. There is a need to fully implement scientific tool guidelines for future experimental studies in order to improve the quality of preclinical studies and facilitate effective translation of their results to the clinic.
Level and predictors of breast cancer awareness among Saudi women: A nationwide study
Authors: Qedair Jumanah T , Al Qurashi Abdullah A , Alfayea Turki , Mortada Hatan , Alsudais Ali , Almuntashiri Saleh , Hakami Alqassem Y 
Published: October 2022

Background: Breast cancer occurs when abnormal breast cells grow rapidly and uncontrollably. Early detection and intervention have been established to significantly decrease mortality rates. Objective: There is a lack of focused research investigating the degree of breast cancer awareness among Saudi women. Thus, this study aimed to fill this gap by conducting a nationwide survey on a large pool of women. Design: A cross-sectional web-based nationwide study. Methods: This study targeted Saudi women from all regions of the country and was conducted from 20 August to 3 September 2021. The study used the Breast Cancer Awareness Measure questionnaire to measure breast cancer awareness. This study was approved by the King Abdullah International Medical Research Center institutional review board. Results: Overall, poor breast cancer awareness scores were demonstrated by 71% of the participants. Unemployed women were more likely to have poor breast cancer awareness. Conclusion: Our study reports an alarmingly high level of poor overall breast cancer awareness in Saudi women. Interventions should be implemented to combat this lack of awareness.
Individual-Specific Relationship Between External Training and Match Load and Creatine-Kinase Response in Youth National Team Soccer Players
Authors: Schuth Gabor , Szigeti Gyorgy , Dobreff Gergely , Pasic Alija , Gabbett Tim , Szilas Adam , Pavlik Gabor 
Published: October 2022

Background: Previous studies have examined the relationship between external load and creatine-kinase (CK) response at the team level. This study aimed to build individualized CK prediction models for elite youth national team soccer players. Hypothesis: The CK response of youth soccer players can be categorized as being sensitive to micromovements (MM), high-velocity (HV) parameters, or the combination of both, measured during training sessions and matches. Study Design: Prospective cohort study. Level of Evidence: Level 4. Methods: A total of 25 U16-U17 youth national team soccer players were monitored during training sessions and matches using global positioning system (GPS) units. Individual CK values were measured every morning from whole blood. The data set consisted of 57 ± 17 individual datapoints per player. Individual prediction models were used to examine the relationship between external load and consecutive CK changes. Numerous models were built for each player using MM, HV parameters, or the combination of both. The performance of the models was described by the R2 and the root mean square error (RMSE, U/l for CK values). Results: The MM models were superior for 8 players ( R2 = 0.68; RMSE = 113 U/l), followed by HV (8 players; R2 = 0.69; RMSE = 88 U/l) and the combined models (2 players; R2 = 0.64; RMSE = 141 U/l). For the remaining 7 players, the R2 of the models was <0.5. The recovery time between efforts was more important in the HV model. Conclusion: Players could be categorized on sensitivity to MM, HV movements, or the combination of both. Clinical Relevance: These findings can be used to individualize postmatch recovery strategies and to optimize weekly training periodization to maximize match performance.
Intra-Articular Injections of the Adipose-Derived Mesenchymal Stem Cells Suppress Progression of a Mouse Traumatic Knee Osteoarthritis Model
Authors: Wakayama Takanori , Saita Yoshitomo , Nagao Masashi , Uchino Sayuri , Yoshihara Sei-ichi , Tsuji Kunikazu , Koga Hideyuki , Kobayashi Yohei , Nishio Hirofumi , Momoi Yasumasa , Ikeda Hiroshi , Kaneko Kazuo , Ishijima Muneaki 
Published: October 2022

Objective This study aimed to determine whether the intra-articular injection of human adipose-derived mesenchymal stem cells (ADSCs) protects against the progression of murine post-traumatic osteoarthritis. Design ADSCs were isolated from human abdomen or buttock adipose tissues. In in vitro study, ADSCs conditioned medium was added to human chondrocytes pre-treated with interleukin-1β (IL-1β), and resultant gene expression of target inflammatory genes was measured by real-time quantitative polymerase chain reaction. A mouse model of knee osteoarthritis was generated by unilaterally transecting the medial meniscus in the right hind limb of 20 female C57BL/6 mice. Mice were randomly assigned to 2 treatment groups that received 6 µl intra-articular injections of either phosphate-buffered saline (control) or 2 × 104 cells/μl of ADSCs 14, 28, and 42 days post-surgery. Mice were euthanized 84 days post-surgery and histological and micro-computed tomography evaluation of knee joints were analyzed. Hind limb weight-bearing distribution was measured pre-surgery and 28 and 84 days post-surgery. Results Conditioned medium from cultured human adipose-derived mesenchymal stem cells suppressed the expression of target inflammatory genes in chondrocytes pre-treated with IL-1β, suggesting anti-inflammatory properties ( P < 0.01). Histological analyses indicated that the progression of destabilization of medial meniscus-induced knee osteoarthritis was suppressed by the administration of ADSCs compared with control group at medial femorotibial joint in vivo. This protective effect was related to a reduction in articular cartilage loss. Conclusion The intra-articular injection of ADSCs suppressed articular cartilage loss in a mouse model of knee osteoarthritis, possible through anti-inflammatory mechanisms.
Clinical Characteristics of Hospital Follow-up for Patients Hospitalized from SARS CoV-2 (COVID 19) in an Academic Outpatient Internal Medicine Clinic
Authors: Abohelwa Mostafa , Peterson Christopher J. , Landis Dylan , Le Duc , Conde Camila , DeWare Charles , Elgendy Fares , Payne Drew , Nugent Kenneth 
Published: October 2022

Background: As of July 2022, there have been more than 91.3 million cases of COVID-19 and nearly 1.03 million deaths in the United States alone. In addition, many people who survived COVID-19 had long-term symptoms, such as fatigue, dyspnea, loss of smell and taste, depression, and anxiety. Objectives: The purpose of our study is to evaluate the status of COVID-19 patients who were previously hospitalized. Methods: We conducted a single-center retrospective cohort study at Texas Tech University Health Sciences Center and its affiliated University Medical Center under IRB of L21-144. We included all patients hospitalized for COVID-19 and followed up in our Internal Medicine Clinic at any time between April 1, 2020, and April 1, 2021, and reviewed follow-up data for these patients after discharge. Results: A total of 128 patients were included; 59 (46%) were men, and 69 (54%) were women with an average age of 59.7 ± 14.8 years. Most of the patients (n = 78, 60.9%) identified their race as Hispanic or Latino origin; the next largest group was Caucasian (n = 29, 22.65%). The average number of days until post-hospitalization follow-up was 36 ± 38 days. The 50% of the patients (n = 64) used telemedicine for follow-up visits. Important comorbidities in these patients included diabetes (n = 84, 65.6%) and hypertension (n = 94, 73.4%). Thirty-four patients (26.6%) reported respiratory symptoms at their follow-up appointments, 24 patients (18.8%) reported constitutional symptoms, 12 patients (9.4%) reported GI symptoms, and 25 patients (19.5%) reported other symptoms, such as paresthesia, lower extremity edema, or psychological symptoms. After hospital discharge, 54 patients had follow-up chest x-rays, and 41 (75.9%) still had abnormal findings consistent with COVID-19 imaging characteristics. Follow-up laboratory tests identified 44 patients (77.2%, 57 tested) with elevated D-dimer levels, 44 patients (78.6%, 56 tested) with high ferritin levels, and 21patients (35.6%, 59 tested) with elevated troponin T HS levels. Conclusion: Long-lasting COVID-19 symptoms in these patients included respiratory symptoms (26.6%), constitutional symptoms (18.8%), GI symptoms (9.4%), and other symptoms, such as paresthesia, lower extremity edema, or psychological symptoms (19.5%). The rate of telehealth follow-up was 50%. Many patients had elevated inflammatory markers that will need follow up to determine the clinical implications.
Association of Training and Game Loads to Injury Risk in Junior Male Elite Ice Hockey Players: A Prospective Cohort Study
Authors: Nordstrøm Anine , Bahr Roald , Bache-Mathiesen Lena K. , Clarsen Ben , Talsnes Ove 
Published: October 2022

Background: Training and game loads are potential risk factors of injury in junior elite ice hockey, but the association of training and game loads to injuries is unknown. Purpose: To investigate the association of chronic training and game loads to injury risk in junior male elite ice hockey players. Study Design: Cohort study; Level of evidence, 2. Methods: In this prospective cohort study, we monitored all health problems among 159 male junior ice hockey players (mean age, 16 years; range, 15-19 years) at sports-specific high schools during the 2018-2019 school year. Players reported their health problems every week using the Oslo Sports Trauma Research Center Overuse Questionnaire on Health Problems (OSTRC-H2). The number of training sessions and games was reported for 33 weeks. We calculated the previous 2-week difference in training/game loads as well as the cumulative training/game loads of the previous 2, 3, 4, and 6 weeks and explored potential associations between training/game loads and injury risk using mixed-effects logistic regression. Results: The players reported 133 acute injuries, 75 overuse injuries, and 162 illnesses in total, and an average of 8.8 (SD ±3.9) training sessions and 0.9 (SD ± 1.1) games per week. We found no association between the difference of the two previous weeks or the previous 2- 3- and 4-week cumulative, training or game load and acute injuries, nor the difference of the two previous weeks, or the previous 4- and 6-week cumulative, training or game load and overuse injuries (OR, ∼1.0; P > .05 in all models). Conclusion: In the current study of junior elite ice hockey players, there was no evidence of an association between cumulative exposure to training/game loads and injury risk.
Effect of Anterior Glenoid Chondrolabral Defects on Anterior Glenohumeral Stability: A Biomechanical Study
Authors: Kawakami Jun , Henninger Heath B. , Knighton Tyler W. , Yamamoto Nobuyuki , Tashjian Robert Z. , Itoi Eiji , Chalmers Peter N. 
Published: October 2022

Background: It is well known that glenoid osseous defects >13.5% of the glenoid width critically destabilize the shoulder, as do labral tears. Chondrolabral defects often occur with anterior dislocation of the shoulder. It is unclear whether glenoid chondrolabral defects contribute to shoulder stability and, if so, at what size they become critical. Purpose/Hypothesis: The purpose of this study was to determine the effect of incremental chondrolabral defect sizes on anterior shoulder stability in the setting of labral deficiency. The hypothesis was that chondrolabral defects ≥13.5% of the glenoid width will decrease anterior shoulder stability. Study Design: Controlled laboratory study. Methods: This controlled laboratory study tested 12 fresh-frozen shoulders. Specimens were attached to a custom testing device in abduction and neutral rotation with 50-N compression applied to the glenoid. The humeral head was translated 10 mm anterior, anteroinferior, and anterosuperior with the conditions of intact cartilage and labrum and anterior full-thickness chondrolabral defects of 3-, 6-, and 9-mm width. Translation force was measured continuously. Peak translation force divided by 50-N compressive force defined the stability ratio. Data were analyzed using analysis of variance. Results: The anterior stability ratio decreased between the intact state (36% ± 7%) and all defects ≥3 mm (≤32% ± 8%; P ≤ .023). The anteroinferior stability ratio decreased between the intact state (52% ± 7%) and all defects ≥3 mm (≤47% ± 7%; P ≤ .006). The anterosuperior stability ratio decreased between the intact state (36% ± 4%) and all defects ≥6 mm (≤33% ± 4%; P ≤ .006). A 3-mm defect equated to 10% of the glenoid width. There were moderate to strong negative correlations between chondrolabral defect size and stability ratio in the anterior, anteroinferior, and anterosuperior directions ( r = –0.79, –0.63, and –0.58, respectively; P ≤ .001). There were moderate to strong negative correlations between the percentage of glenoid chondrolabral defect size to the glenoid width and the stability percentage in all directions ( r = –0.81, –0.63, and –0.61; P ≤ .001). Conclusion: An anterior glenoid chondrolabral defect ≥3 mm (>10% of the glenoid width) significantly decreased anterior and anteroinferior stability. Chondrolabral defect size negatively correlated with stability. Clinical Relevance: To fully restore glenohumeral stability, in addition to labral repair, it may be necessary to reconstruct chondrolabral defects as small as 3 mm (10% of the glenoid width).
What really matters for patient safety: Correlation of nurse competence with international patient safety goals
Authors: Kalsoom Zubia , Victor Gideon , Virtanen Heli , Sultana Nuzhat 
Published: October 2022

Background Optimal level of nurse competence is imperative for patient safety and quality of care. A research gap exists in empirical evidence for associating nurses’ competencies with patient safety. Purpose The primary purpose of this study was to measure the association between general ward nurses' competencies with international patient safety goals. Method Correlational research design was adopted. Stratified random sampling was used to recruit (n  =  182) nurses working in two JCIA accredited and non-JCIA hospitals. Data were collected using the Competency Inventory for Registered Nurses and International Patient Safety Goals. The research was approved by the Institutional review board and ethics committee. Findings The regression analysis showed enhancement of patient safety with an improvement in nurse competencies R2  =  0.238. Nurse competencies showed a moderate positive association with an overall patient safety such as critical thinking and research aptitude (r  =  0.420, P – Value < 0.001), teaching coaching (r  =  0.469, P- Value <0.01), professional development (r  =  0.436, P – Value < 0.001), legal and ethical practices (r  =  0.434, P –Value < 0.001), interpersonal relationships (r  =  0.430, P –Value < 0.001), Leadership (r  =  0.400, P –Value < 0.001), and Clinical Care (r  =  0.541, P –Value < 0.001). Moreover, experience and professional education show positive association with both, patient safety and nurses’ competencies. Conclusion Nurses’ clinical competencies are crucial to enhance patient safety. Personal and professional attributes affect the competencies of nurses and patient safety. Hospital management should take mandatory steps to ensure improving nurses’ competencies for better patient safety.
Visual Cu2+ Detection of Gold-Nanoparticle Probes and its Employment for Cu2+ Tracing in Circuit System
Authors: Ou Tzu-Yu , Lo Chien-Feng , Kuo Kuan-Yi , Lin Yu-Pin , Chen Sung-Yu , Chen Chia-Yun 
Published: October 2022

AbstractHighly sensitive, simple and reliable colorimetric probe for Cu2+-ion detection was visualized with the L-cysteine functionalized gold nanoparticle (LS-AuNP) probes. The pronounced sensing of Cu2+with high selectivity was rapidly featured with obvious colour change that enabled to visually sense Cu2+ions by naked eyes. By employing systemic investigations on crystallinities, elemental compositions, microstructures, surface features, light absorbance, zeta potentials and chemical states of LS-AuNP probes, the oxidation-triggered aggregation effect of LS-AuNP probes was envisioned. The results indicated that the mediation of Cu2+oxidation coordinately caused the formation of disulfide cystine, rendering the removal of thiol group at AuNPs surfaces. These features reflected the visual colour change for the employment of tracing Cu2+ions in a quantitative way.