bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entrapment and Manipulation
Authors: Haeg Jonas 
Published: November 2022

AbstractWhy is wrong to punish criminals who have been entrapped by the state? The paper begins by presenting some criticisms of existing answers to this question. First, they fail to put the target, or victim, of entrapment at the centre of the moral explanation. Second, they fail to account for the intuitive relation between the reasons not to entrap and the reasons not to punish. Third, they struggle to account for the existence of agent-neutral reasons not to punish entrapped offenders. Lastly, they are ill-equipped to explain why entrapment seems problematic also outside the legal context. In response, the paper develops a novel account of entrapment: the Manipulation Account. According to this, entrapment always involves a particular kind of manipulation (manipulation-by-hidden-intentions) which morally taints punishment. In short, I suggest that both the initial entrapment and the subsequent punishment involve wrongful manipulation. Lastly, the paper presents some untraditional, but ultimately welcoming, implications of the account.
Harmony in a panpsychist world
Authors: Saad Bradford 
Published: November 2022

AbstractExperiences tend to be followed by states for which they provide normative reasons. Such harmonious correlations cry out for explanation. Theories that answer or diminish these cries thereby achieve an advantage over theories that do neither. I argue that the main lines of response to these cries that are available to biological theorists—theorists who hold (roughly) that conscious subjects are generally biological entities—are problematic. And I argue that panpsychism—which holds (roughly) that conscious subjects are ubiquitous in nature—provides an attractive response to these explanatory cries. Taken together, these considerations underwrite a kind of ‘psychophysical fine-tuning’ argument in support of panpsychism, one that is reminiscent of cosmological fine-tuning arguments in favor of multiverse hypotheses.
The Elastic Effect of Evolving Precipitate Shapes on the Ripening Kinetics of Tetragonal Phases
Authors: Schleifer Felix , Lin Yueh-Yu , Glatzel Uwe , Fleck Michael 
Published: November 2022

Abstract
Coherent tetragonal precipitates, such as the Ni3Nb phase γ″ found in Ni-base superalloys, appear as plate-shaped particles. These shapes are the result of anisotropic elastic misfit strains. We present 3D sharp phase-field simulations that capture this circumstance well due to the inclusion of the elastic effects from the misfit. These simulations reveal that the ripening behavior of γ″ precipitates deviates significantly from the classical LSW theory of Ostwald ripening. A ripening exponent of 2 rather than 3 describes the simulated γ″ size evolution at temperatures between 700 °C and 760 °C best. Employing a quantitative distinction argument, we show that 60 pct of this deviation is attributed to the elastically induced size dependence of the precipitate shapes. With increasing precipitate size, the minimization of elastic energy leads to steadily increasing plate aspect ratios. The precipitate ripening kinetics accelerate with increasing aspect ratio. Fitting the newly received square root time dependence to experimental data yields a physically conclusive activation energy of ripening close to the activation energy of Nb diffusion in the alloy.
Enhancement of Immunosuppressive Activity of Mesenchymal Stromal Cells by Platelet-Derived Factors is Accompanied by Apoptotic Priming
Authors: Trivanovic Drenka , Volkmann Noah , Stoeckl Magdalena , Tertel Tobias , Rudert Maximilian , Giebel Bernd , Herrmann Marietta 
Published: November 2022

Abstract
The pro-inflammatory phase of bone healing, initiated by platelet activation and eventually hematoma formation, impacts bone marrow mesenchymal stromal cells (MSCs) in unknown ways. Here, we created platelet-rich plasma (PRP) hydrogels to study how platelet-derived factors modulate functional properties of encapsulated MSCs in comparison to a non-inflammatory fibrin (FBR) hydrogel environment. MSCs were isolated from human bone marrow, while PRP was collected from pooled apheresis thrombocyte concentrates and used for hydrogel preparation. After their encapsulation in hydrogels for 72 h, retrieved MSCs were analyzed for immunomodulatory activities, apoptosis, stem cell properties, senescence, CD9+, CD63+ and CD81+ extracellular vesicle (EV) release, and metabolism-related changes. PRP-hydrogels stimulated immunosuppressive functions of MSCs, along with their upregulated susceptibility to cell death in communication with PBMCs and augmented caspase 3/7 activity. We found impaired clonal growth and cell cycle progression, and more pronounced β-galactosidase activity as well as accumulation of LC3-II-positive vacuoles in PRP-MSCs. Stimuli derived from PRP-hydrogels upregulated AKT and reduced mTOR phosphorylation in MSCs, which suggests an initiation of survival-related processes. Our results showed that PRP-hydrogels might represent a metabolically stressful environment, inducing acidification of MSCs, reducing polarization of the mitochondrial membrane and increasing lipid accumulation. These features were not detected in FBR-MSCs, which showed reduced CD63+ and CD81+ EV production and maintained clonogenicity. Our data revealed that PRP-derived hematoma components cause metabolic adaptation of MSCs followed by increased immune regulatory functions. For the first time, we showed that PRP stimuli represent a survival challenge and “apoptotic priming” that are detrimental for stem cell-like growth of MSCs and important for their therapeutic consideration.
Graphical Abstract
Consequences of Mouth Closure and Hypoxia-Induced State Changes in Low-Inflow Estuaries: Benthic Community and Trait-Based Response
Authors: Levin Lisa A. , Mendoza Guillermo F. , Neira Carlos , Giddings Sarah N. , Crooks Jeffrey A. 
Published: November 2022

AbstractThe southern California coastline hosts low-inflow estuaries that have mouths that periodically close. Low-inflow estuaries can become hypoxic and are then often opened mechanically. The consequences of mouth closure and hypoxia (< 2 mg L−1 O2) on macrobenthic densities, species richness, diversity, composition, and biological traits were evaluated for legacy data generated by the Pacific Estuarine Research Lab for Los Peñasquitos Lagoon (LPL) (1991–2006) and Tijuana Estuary (TJE) (1988–2004). LPL closed at least annually and TJE remained open during the study period. Effects were moderated by zone within the estuary (relative to the mouth) and season. Periodic closure in LPL was associated with raised macrofaunal density and diversity, especially at the mouth, and with suppressed seasonality. Closure favored soft-bodied (non-calcified) non-bioturbating, mobile, epifaunal taxa in LPL with planktotrophic development, large branchiae, and no vision. There were more spionid and capitellid polychaetes, Traskorchestia traskiana, Cerithideopsis californica, Tagelus californianus, and phoronids during closure. In contrast, hypoxia (< 2 mg L−1) measured during faunal sampling was associated with lower densities in LPL and different taxonomic composition, but no difference in taxon richness or diversity. There were more corophiid amphipods, small snails, tubificid oligochaetes, Palaemon macrodactylus (shrimp), and Trichorixa reticulata (insects) under hypoxic conditions, and retention of taxa with very large or small bodies and with vision. TJE densities were nearly double those of LPL; taxon richness and diversity (H’) were also higher in TJE. TJE hosted more burrowing, large-bodied, highly calcified taxa with planktotrophic development and no vision than LPL. Differences in composition and traits between the two estuaries disappeared in the middle and upper reaches, where ocean flushing was more limited. Historical long-term monitoring data for benthos, such as the data set analyzed here, offer a valuable baseline for evaluating ecosystem response to changes induced by climate, infrastructure development, contamination, or restoration.
A Comparative Perspective on the Cerebello-Cerebral System and Its Link to Cognition
Authors: Magielse Neville , Heuer Katja , Toro Roberto , Schutter Dennis J. L. G. , Valk Sofie L. 
Published: November 2022

Abstract
The longstanding idea that the cerebral cortex is the main neural correlate of human cognition can be elaborated by comparative analyses along the vertebrate phylogenetic tree that support the view that the cerebello-cerebral system is suited to support non-motor functions more generally. In humans, diverse accounts have illustrated cerebellar involvement in cognitive functions. Although the neocortex, and its transmodal association cortices such as the prefrontal cortex, have become disproportionately large over primate evolution specifically, human neocortical volume does not appear to be exceptional relative to the variability within primates. Rather, several lines of evidence indicate that the exceptional volumetric increase of the lateral cerebellum in conjunction with its connectivity with the cerebral cortical system may be linked to non-motor functions and mental operation in primates. This idea is supported by diverging cerebello-cerebral adaptations that potentially coevolve with cognitive abilities across other vertebrates such as dolphins, parrots, and elephants. Modular adaptations upon the vertebrate cerebello-cerebral system may thus help better understand the neuroevolutionary trajectory of the primate brain and its relation to cognition in humans. Lateral cerebellar lobules crura I-II and their reciprocal connections to the cerebral cortical association areas appear to have substantially expanded in great apes, and humans. This, along with the notable increase in the ventral portions of the dentate nucleus and a shift to increased relative prefrontal-cerebellar connectivity, suggests that modular cerebellar adaptations support cognitive functions in humans. In sum, we show how comparative neuroscience provides new avenues to broaden our understanding of cerebellar and cerebello-cerebral functions in the context of cognition.
Spatiotemporal EEG Dynamics of Prospective Memory in Ageing and Mild Cognitive Impairment
Authors: Crook-Rumsey Mark , Howard Christina J. , Doborjeh Zohreh , Doborjeh Maryam , Ramos Josafath Israel Espinosa , Kasabov Nikola , Sumich Alexander 
Published: November 2022

Abstract
Prospective memory (PM, the memory of future intentions) is one of the first complaints of those that develop dementia-related disease. Little is known about the neurophysiology of PM in ageing and those with mild cognitive impairment (MCI). By using a novel artificial neural network to investigate the spatial and temporal features of PM related brain activity, new insights can be uncovered. Young adults (n = 30), healthy older adults (n = 39) and older adults with MCI (n = 27) completed a working memory and two PM (perceptual, conceptual) tasks. Time-locked electroencephalographic potentials (ERPs) from 128-electrodes were analysed using a brain-inspired spiking neural network (SNN) architecture. Local and global connectivity from the SNNs was then evaluated. SNNs outperformed other machine learning methods in classification of brain activity between younger, older and older adults with MCI. SNNs trained using PM related brain activity had better classification accuracy than working memory related brain activity. In general, younger adults exhibited greater local cluster connectivity compared to both older adult groups. Older adults with MCI demonstrated decreased global connectivity in response to working memory and perceptual PM tasks but increased connectivity in the conceptual PM models relative to younger and healthy older adults. SNNs can provide a useful method for differentiating between those with and without MCI. Using brain activity related to PM in combination with SNNs may provide a sensitive biomarker for detecting cognitive decline. Cognitively demanding tasks may increase the amount connectivity in older adults with MCI as a means of compensation.
Development of bioactive electrospun scaffolds suitable to support skin fibroblasts and release Lucilia sericata maggot excretion/secretion
Authors: Giacaman Annesi G. , Styliari Ioanna D. , Taresco Vincenzo , Pritchard David , Alexander Cameron , Rose Felicity R. A. J. 
Published: November 2022

AbstractLarval therapy has been reported to be beneficial in the treatment of chronic wounds by promoting granulation tissue formation, due to its antimicrobial properties and by degrading necrotic tissue. However, the use of live maggots is problematic for patient acceptance, and thus there is a need to develop materials which can release therapeutic biomolecules derived from maggot secretions to the wound bed. Here we describe the fabrication of a novel bioactive scaffold that can be loaded with Lucilia sericata maggot alimentary excretion/secretion fluids (L. sericata maggot E/S), and which can also provide structural stability for mammalian cell-growth and migration to support wound repair. Electrospun scaffolds were prepared from a poly(caprolactone)-poly(ethylene glycol)–block copolymer (PCL-b-PEG) blended with PCL with average fibre diameters of ~ 4 μm. The scaffolds were hydrophilic and were able to support viable fibroblasts that were able to infiltrate throughout the extent of the scaffold thickness. L. sericata maggot (E/S) was subsequently adsorbed to the surface and released over 21 days with retention of the protease activity that is responsible for supporting fibroblast migration. The incorporation of L. sericata maggot E/S on the surface of the electrospun fibres of PCL-PEG/PCL fibres is a novel approach with potential for future application to support skin wound healing within a clinical setting.
Transcription factor CsESE3 positively modulates both jasmonic acid and wax biosynthesis in citrus
Authors: Wan Haoliang , Qiu Haiji , Li Zhuoran , Zhang Xiaoliang , Zhang Jingyu , Jiang Deyuan , Fernie Alisdair R. , Lyu Yi , Cheng Yunjiang , Wen Weiwei 
Published: November 2022

Abstract
PLIP lipases can initiate jasmonic acid (JA) biosynthesis. However, little is known about the transcriptional regulation of this process. In this study, an ERF transcription factor (CsESE3) was found to be co-expressed with all necessary genes for JA biosynthesis and several key genes for wax biosynthesis in transcriptomes of ‘Newhall’ navel orange. CsESE3 shows partial sequence similarity to the well-known wax regulator SHINEs (SHNs), but lacks a complete MM protein domain. Ectopic overexpression of CsESE3 in tomato (OE) resulted in reduction of fruit surface brightness and dwarf phenotype compared to the wild type. The OE tomato lines also showed significant increases in the content of wax and JA and the expression of key genes related to their biosynthesis. Overexpression of CsESE3 in citrus callus and fruit enhanced the JA content and the expression of JA biosynthetic genes. Furthermore, CsESE3 could bind to and activate the promoters of two phospholipases from the PLIP gene family to initiate JA biosynthesis. Overall, this study indicated that CsESE3 could mediate JA biosynthesis by activating PLIP genes and positively modulate wax biosynthesis. The findings provide important insights into the coordinated control of two defense strategies of plants represented by wax and JA biosynthesis.
Cingulate cortical thickness in cocaine use disorder: mediation effect between early life stress and cocaine consumption
Authors: Bittencourt Augusto Martins Lucas , Silveira Bárbara Luiza Belmonte da , Tondo Lucca Pizzato , Rothmann Leonardo Melo , Franco Alexandre Rosa , Ferreira Pedro Eugenio Mazzucchi Santana , Viola Thiago Wendt , Grassi-Oliveira Rodrigo 
Published: November 2022

AbstractObjective:The cingulate gyrus is implicated in the neurobiology of addiction, such as chronic cocaine consumption. Early life stress (ELS) is an important moderator of cocaine use disorder (CUD). Therefore, we investigated the effect of CUD on cingulate cortical thickness and tested whether a history of ELS could influence the effects of CUD.Methods:Participants aged 18–50 years (78 with CUD due to crack cocaine consumption and 53 healthy controls) underwent magnetic resonance imaging and the cingulate thickness (rostral anterior, caudal anterior, posterior, and isthmus regions) was analysed. The clinical assessment comprised the Childhood Trauma Questionnaire (CTQ) and the Addiction Severity Index. Group comparisons adjusting by sex, age, and education were performed. Mediation models were generated where lifetime cocaine use, CTQ score, and cortical thickness corresponded to the independent variable, intermediary variable, and outcome, respectively.Results:Group comparisons revealed significant differences in six out of eight cingulate cortices, showing lower thickness in the CUD group. Furthermore, years of regular cocaine use was the variable most associated with cingulate thickness. Negative correlations were found between CTQ scores and the isthmus cingulate (right hemisphere), as well as with the rostral anterior cingulate (left hemisphere). In the mediation analysis, we observed a significant negative direct effect of lifetime cocaine use on the isthmus cingulate and an indirect effect of cocaine use mediated by CTQ score.Conclusion:Our findings suggest that a history of ELS could aggravate the negative effects of chronic cocaine use on the cingulate gyrus, particularly in the right isthmus cingulate cortex
ANALYTIC SPREAD OF FILTRATIONS ON TWO-DIMENSIONAL NORMAL LOCAL RINGS
Authors: CUTKOSKY STEVEN DALE 
Published: November 2022

AbstractIn this paper, we prove that a classical theorem by McAdam about the analytic spread of an ideal in a Noetherian local ring continues to be true for divisorial filtrations on a two-dimensional normal excellent local ringR, and that the Hilbert polynomial of the fiber cone of a divisorial filtration onRhas a Hilbert function which is the sum of a linear polynomial and a bounded function. We prove these theorems by first studying asymptotic properties of divisors on a resolution of singularities of the spectrum ofR. The filtration of the symbolic powers of an ideal is an example of a divisorial filtration. Divisorial filtrations are often not Noetherian, giving a significant difference in the classical case of filtrations of powers of ideals and divisorial filtrations.
Understanding collaboration patterns on funded research projects: A network analysis
Authors: Smith Matthew , Sarabi Yasaman , Christopoulos Dimitris 
Published: November 2022

AbstractThis paper provides an examination of inter-organizational collaboration in the UK research system. Data are collected on organizational collaboration on projects funded by four key UK research councils: Arts and Humanities Research Council, Economic and Social Research Council, Engineering and Physical Sciences Research Council, and Biotechnology and Biological Sciences Research Council. The organizational partnerships include both academic and nonacademic institutions. A collaboration network is created for each research council, and an exponential random graph model is applied to inform on the mechanisms underpinning collaborative tie formation on research council-funded projects. We find that in the sciences, collaborative patterns are much more hierarchical and concentrated in a small handful of actors compared to the social sciences and humanities projects. Institutions that are members of the elite Russell Group (a set of 24 high-ranking UK universities) are much more likely to be involved in collaborations across research councils.
Double relative commutants in coronas of separable C*-algebras
Authors: Kučerovský Dan , Mathieu Martin 
Published: November 2022

AbstractWe prove a double commutant theorem for separable subalgebras of a wide class of corona C*-algebras, largely resolving a problem posed by Pedersen in 1988. Double commutant theorems originated with von Neumann, whose seminal result evolved into an entire field now called von Neumann algebra theory. Voiculescu later proved a C*-algebraic double commutant theorem for subalgebras of the Calkin algebra. We prove a similar result for subalgebras of a much more general class of so-called corona C*-algebras.
Risk factors for the development of opioid use disorder after first opioid prescription: a Swedish national study
Authors: Kendler Kenneth S. , Lönn Sara L. , Ektor-Andersen John , Sundquist Jan , Sundquist Kristina 
Published: November 2022

AbstractBackgroundWe need to better understand the frequency and predictors of opioid use disorder (OUD) after first opioid prescription (OP).MethodsWe followed 1 516 392 individuals from the Swedish population born 1980–2000, from 1 July 2007, until 31 Dec 2017. We examined putative risk predictors with univariable and multivariable Cox Models and the potential causal effects of predictors by propensity score and co-sibling analyses.ResultOf the individuals in our cohort, 24.8% (375 404) received a first OP, of whom 3034 (0.90%) developed a subsequent first OUD. The hazard ratio (HR) (± 95% CIs) for OUD after OP equaled 7.10 (6.75–7.46), with a mean time to onset of 3.41 (2.39) years. The strongest putative risk factors for development of OUD after OP were prior psychiatric and substance use disorders, criminal behavior, parental divorce/death, poor school performance, current community deprivation, divorce, and male sex. Few predictors differed across sexes. OP renewal was associated with a HR of 3.66 (3.41–3.93) for OUD. Co-sibling and propensity score analyses suggested that at least a moderate proportion of the risk factor-OUD association was likely causal. A risk score to predict OUD after OP had an AUC of 0.85, where nearly 60% of cases scoring in the top decile.ConclusionsIn a general population sample, an OP represents a substantial risk factor for subsequent OUD. Many of the risk factors for OUD after OP can be readily assessed at the time of potential OP, permitting clinicians to evaluate the risk of iatrogenic OUD.
A Note on Learning, House Prices, and Macro-Financial Linkages
Authors: Gandré Pauline 
Published: November 2022

AbstractIn the USA, the linkages between the housing market, the credit market, and the real sector have been striking in the past decades. To explain these linkages, I develop a small-scale dynamic stochastic general equilibrium (DSGE) model in which agents update non-rational beliefs about future house price growth, in accord with recent survey data evidence. Both standard productivity shocks and shocks in the credit sector generate endogenously persistent booms in house prices. Long-lasting excess volatility in house prices, in turn, affects the financial sector and propagates to the real sector. This amplification and propagation mechanism improves the ability of the model to explain empirical puzzles in the US housing market and to explain the macro-financial linkages during 1985−2019. The learning model can also replicate the predictability of forecast errors evidenced in recent survey data.