bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase I Study of Androgen Deprivation Therapy in Combination with Anti–PD-1 in Melanoma Patients Pretreated with Anti–PD-1
Authors: Robert Caroline , Lebbé Céleste , Lesimple Thierry , Lundström Eija , Nicolas Valérie , Gavillet Bruno , Crompton Philippa , Baroudjian Barouyr , Routier Emilie , Lejeune Ferdy J. 
Published: December 2022

AbstractPurpose:Androgen deprivation regenerates the thymus in adults, expanding of T-cell receptor V β repertoire in blood and lymphoid organs and tumor-infiltrating lymphocytes in human prostate tumors. In melanoma murine models, androgen receptor promotes metastases and androgen blockade potentiates antitumor vaccine efficacy. This phase I study evaluated the safety, efficacy, and pharmocodynamics of androgen deprivation with the gonadotropin releasing hormone (GnRH) agonist triptorelin combined with nivolumab in male patients with melanoma resistant to anti–PD-1.Patients and Methods:Adult male patients with advanced melanoma who progressed under anti–PD-1 containing regimens received triptorelin 3.75 mg every 4 weeks, nivolumab 3 mg/kg every 2 weeks, and bicalutamide 50 mg once daily during the first 28 days. Tumor response was first assessed after 3 months; adverse events (AE) were monitored throughout the study. T-cell receptor excision circles (TREC), a biomarker of thymus activity, were explored throughout the study.Results:Of 14 patients, 4 were locally advanced and 10 had distant metastases. There were no grade 4 or 5 AEs. Five grade three AEs were reported in 4 patients. According to RECIST v1.1, best overall response was partial response (PR) in one patient with a pancreas metastasis, stable disease (SD) in 5 patients, and progressive disease in 8 patients. According to iRECIST, a second PR occurred after an initial pseudoprogression, TRECs increased in 2 patients, one with PR who also had an increase in TILs, and the second with SD.Conclusions:This combination was well tolerated. Disease control was obtained in 42.8% (RECIST) and 50% (iRECIST). The evidence for thymus rejuvenation was limited.
Utility of the ACC/AHA Lesion Classification to Predict Outcomes After Contemporary DES Treatment: Individual Patient Data Pooled Analysis From 7 Randomized Trials
Authors: Konigstein Maayan , Redfors Björn , Zhang Zixuan , Kotinkaduwa Lak N. , Mintz Gary S. , Smits Pieter C. , Serruys Patrick W. , von Birgelen Clemens , Madhavan Mahesh V. , Golomb Mordechai , Ben‐Yehuda Ori , Mehran Roxana , Leon Martin B. , Stone Gregg W. 
Published: December 2022

Background
Use of the modified American College of Cardiology (ACC)/American Heart Association (AHA) lesion classification as a prognostic tool to predict short‐ and long‐term clinical outcomes after percutaneous coronary intervention in the modern drug‐eluting stent era is uncertain.

Methods and Results

Patient‐level data from 7 prospective, randomized trials were pooled. Clinical outcomes of patients undergoing single lesion percutaneous coronary intervention with second‐generation drug‐eluting stent were analyzed according to modified ACC/AHA lesion class. The primary end point was target lesion failure (TLF: composite of cardiac death, target vessel myocardial infarction, or ischemia‐driven target lesion revascularization). Clinical outcomes to 5 years were compared between patients treated for noncomplex (class A/B1) versus complex (class B2/C) lesions. Eight thousand five hundred sixteen patients (age 63.1±10.8 years, 70.5% male) were analyzed. Lesions were classified as A, B1, B2, and C in 7.9%, 28.5%, 33.7%, and 30.0% of cases, respectively. Target lesion failure was higher in patients undergoing percutaneous coronary intervention of complex versus noncomplex lesions at 30 days (2.0% versus 1.1%,
P
=0.004), at 1 year (4.6% versus 3.0%,
P
=0.0005), and at 5 years (12.4% versus 9.2%,
P
=0.0001). By multivariable analysis, treatment of ACC/AHA class B2/C lesions was significantly associated with higher rate of 5‐year target lesion failure (adjusted hazard ratio, 1.39 [95% CI, 1.17–1.64],
P
=0.0001) driven by significantly higher rates of target vessel myocardial infarction and ischemia‐driven target lesion revascularization.

Conclusions
In this pooled large‐scale analysis, treating complex compared with noncomplex lesions according to the modified ACC/AHA classification with second‐generation drug‐eluting stent was associated with worse 5‐year clinical outcomes. This historical classification system may be useful in the contemporary era for predicting early and late outcomes following percutaneous coronary intervention.
Dihydropyridine Calcium Channel Blockers and Risk of Pancreatic Cancer: A Population‐Based Cohort Study
Authors: Rouette Julie , McDonald Emily G. , Schuster Tibor , Brophy James M. , Azoulay Laurent 
Published: December 2022

Background
Recent studies have reported that dihydropyridine calcium channel blockers (dCCBs) may increase the risk of pancreatic cancer, but these studies had methodological limitations. We thus aimed to determine whether dCCBs are associated with an increased risk of pancreatic cancer compared with thiazide diuretics, a clinically relevant comparator.

Methods and Results
We conducted a new user, active comparator, population‐based cohort study using the UK Clinical Practice Research Datalink. We identified new users of dCCBs and new users of thiazide diuretics between 1990 and 2018, with follow‐up until 2019. Cox proportional hazards models were used to estimate hazard ratios (HRs) with 95% CIs for pancreatic cancer, comparing dCCBs with thiazide diuretics. Models were weighted using standardized morbidity ratio weights based on calendar time‐specific propensity scores. We also conducted secondary analyses by cumulative duration of use, time since initiation, and individual drugs and assessed for the presence of effect modification by age, sex, smoking status, body mass index, history of chronic pancreatitis, and diabetes. The cohort included 344 480 initiators of dCCBs and 357 968 initiators of thiazide diuretics, generating 3 360 745 person‐years of follow‐up. After a median follow‐up of 4.5 years, the weighted incidence rate per 100 000 person‐years was 37.2 (95% CI, 34.1–40.4) for dCCBs and 39.4 (95% CI, 36.1–42.9) for thiazide diuretics. Overall, dCCBs were not associated with an increased risk of pancreatic cancer (weighted HR, 0.93; 95% CI, 0.80–1.09). Similar results were observed in secondary analyses.

Conclusions
In this large, population‐based cohort study, dCCBs were not associated with an increased risk of pancreatic cancer compared with thiazide diuretics. These findings provide reassurance regarding the long‐term pancreatic cancer safety of these drugs.
SerpinG1: A Novel Biomarker Associated With Poor Coronary Collateral in Patients With Stable Coronary Disease and Chronic Total Occlusion
Authors: Chen Shuai , Li Le‐Ying , Wu Zhi‐Ming , Liu Yong , Li Fei‐Fei , Huang Ke , Wang Yi‐Xuan , Chen Qiu‐Jing , Wang Xiao‐Qun , Shen Wei‐Feng , Zhang Rui‐Yan , Shen Ying , Lu Lin , Ding Feng‐Hua , Dai Yang 
Published: December 2022

Background
This study aimed to explore predictive biomarkers of coronary collateralization in patients with chronic total occlusion.

Methods and Results

By using a microarray expression profiling program downloaded from the Gene Expression Omnibus database, weighted gene coexpression network analysis was constructed to analyze the relationship between potential modules and coronary collateralization and screen out the hub genes. Then, the hub gene was identified and validated in an independent cohort of patients (including 299 patients with good arteriogenic responders and 223 patients with poor arteriogenic responders). Weighted gene coexpression network analysis showed that
SERPING1
in the light‐cyan module was the only gene that was highly correlated with both the gene module and the clinical traits. Serum levels of serpinG1 were significantly higher in patients with bad arteriogenic responders than in patients with good arteriogenic responders (472.53±197.16 versus 314.80±208.92 μg/mL;
P
<0.001) and were negatively associated with the Rentrop score (Spearman
r
=−0.50;
P
<0.001). Receiver operating characteristic curve analysis indicated that the area under the curve was 0.77 (95% CI, 0.72–0.81;
P
<0.001) for serum serpinG1 in prediction of bad arteriogenic responders. After adjusting for traditional cardiovascular risk factors, serum serpinG1 levels (per SD) remained an independent risk factor for bad arteriogenic responders (odds ratio, 2.20 [95% CI, 1.76–2.74];
P
<0.001).

Conclusions

Our findings illustrate that
SERPING1
screened by weighted gene coexpression network analysis was associated with poor collateralization in patients with chronic total occlusion.
Erratum: Annotation Curricula to Implicitly Train Non-Expert
Annotators
Authors: Lee Ji-Ung , Klie Jan-Christoph , Gurevych Iryna 
Published: December 2022

Abstract
The authors of this work (“Annotation Curricula to Implicitly Train Non-Expert Annotators” by Ji-Ung Lee, Jan-Christoph Klie, and Iryna Gurevych in Computational Linguistics 48:2 https://doi.org/10.1162/coli_a_00436) discovered an incorrect inequality symbol in section 5.3 (page 360). The paper stated that the differences in the annotation times for the control instances result in a p-value of 0.200 which is smaller than 0.05 (p = 0.200 &lt; 0.05). As 0.200 is of course larger than 0.05, the correct inequality symbol is p = 0.200 &gt; 0.05, which is in line with the conclusion that follows in the text. The paper has been updated accordingly.
Changes in Summer Precipitation Modes over Eastern China in Simulated Warm Intervals of the Last Interglacial, Mid-Holocene, and Twenty-First Century
Authors: Wu Beilei , Lang Xianmei , Jiang Dabang 
Published: December 2022

Abstract
The East Asian summer monsoon (EASM) and associated summer precipitation patterns over eastern China have exhibited interannual and interdecadal variations in recent decades, but whether the precipitation modes vary with climate conditions remains unclear. In this study, we investigate the changes in summer precipitation modes over eastern China and associated mechanisms in simulated past and future warm periods, namely, the last interglacial (LIG), mid-Holocene, and the twenty-first century under the Shared Socioeconomic Pathway (SSP) based on representative concentration pathway 8.5 (SSP5–8.5) scenario, using Coupled Model Intercomparison Project Phase 6 (CMIP6) models. The model evaluation indicates that only one out of nine CMIP6 models, specifically the Community Earth System Model, version 2 (CESM2), can well reproduce the observed summer precipitation modes at the present. The empirical orthogonal function (EOF) analyses of the CESM2 simulations reveal that during the warm periods induced by either orbital parameters or greenhouse gas concentrations, the first leading mode of summer precipitation switches from its present meridional tripolar structure to a dipole pattern, and the second leading mode is generally a meridional tripolar mode that differs from the present dipole pattern. This summer precipitation regime interchange in the warm intervals is associated with the formation of the dipole and tripolar circulation patterns. The large-scale circulation changes responsible for the altered precipitation modes are attributed to the enhanced EASM and relevant southerly winds due to intensified land–sea thermal contrast, although the external forcings and the magnitude of EASM enhancement are different in the interglacial and future periods.
Virtual Versus In-Person Head and Neck Physical Examination Training in Medical Students: A Pilot Assessment
Authors: Kharidia Khush M. , Lin Matthew E. , West Jonathan D. , Sarode Deepika N. , Ma Harrison J. , Vanstrum Erik B. , Wu Franklin M. , Johns Michael M. 
Published: December 2022

Objective: To compare the effect of virtual and in-person head and neck physical examination training events on medical student confidence in performing examination maneuvers and seeking mentorship from otolaryngology faculty and residents. Methods: Training events were held with first-year medical student volunteers in 2020 (in-person) and 2021 (virtual). Participants in both cohorts were given didactics on head and neck cancer, trained to perform a head and neck physical examination, and demonstrated their clinical skills to otolaryngology faculty and residents. Pre- and post-training surveys were utilized to assess the following outcomes: participant head and neck cancer knowledge, confidence in performing examination maneuvers, and confidence in seeking mentorship in otolaryngology. Differences in outcomes between training settings were assessed by comparing participant survey responses pre- and post- training. Results: Both in-person and virtual training modalities improved participant confidence in performing the physical examination. There was no significant difference in the degree of improvement between training types. In-person training significantly increased participant confidence in seeking mentorship from otolaryngology faculty and residents ( P = .003), while virtual training did not ( P = .194). Conclusion: Virtual training modalities are feasible methods of teaching the head and neck physical examination. Instruction through a video conferencing platform has the potential to be incorporated into traditional in-person medical education in a permanent fashion. This pilot study can inform future studies directly comparing in-person and virtual physical examination training modalities.
Price Impact of Derivatives Listing and Delisting: Evidence from India
Authors: Kumar Rahul , Chakrabarti Prasenjit 
Published: December 2022

This article investigates the spot market’s short-term price reaction on derivatives listing and delisting in India. We comprehensively examine the derivatives listing and delisting with extended time-series data from 2001-2020. We employ event study methodology and find that stocks show positive price reactions on the inclusion, whereas, on the exclusion, stocks show adverse price reactions. In addition, we validate our findings by considering the announcement date and actual date as our event date. We also examine the cross-sectional drivers of cumulative abnormal returns. We find that the underlying liquidity and volatility are critical drivers of cumulative abnormal returns. We produce evidence that derivatives listing (delisting) around the event window significantly increases (decreases) the prices of its underlying. The study attempt to contribute to option listing literature by analyzing the firm-specific cross-sectional drivers of cumulative abnormal returns. JEL Codes: G11, G12, G14
Revisiting Economic Growth and Steel Consumption: Evidence from India
Authors: Paul Pinku , Mitra Paroma 
Published: December 2022

The article analytically investigates the association between GDP growth and steel consumption in India from 2004–2005 to 2019–2020. We investigate the association of both long-term and short-term by employing the Granger causality test in the vector error correction model. The results showed one-way causality between economic growth to steel consumption both in the long and short run and concludes that over the period there is a unidirectional movement from economic development to steel consumption. So, as the economy progresses it has a direct impact on the steel industry. Finally, the study forecast the steel demand for the next decade and highlights the readiness of the steel industry to meet its demand and focus on better utilisation of its capacity. JEL Codes: C51, E2, E27
Study of metabolic syndrome indicators in newly diagnosed diabetes mellitus type 2 patients in Pakistani population
Authors: Ahmad Hajra , Ahmed Zaheer , Kashif Seemin , Liaqat Saba , Afreen Asma 
Published: December 2022

Background Metabolic syndrome (MetS) being a biological abnormality confers the highest risk of type 2 diabetes mellitus (T2DM). Aim To assess MetS indicators in the newly diagnosed T2DM Pakistani population. Methods A cross-sectional study ( N = 123) with newly diagnosed T2DM patients (gender: both, MeanAge: 49.24 ± 6.84 years) was selected from Medical OPD, Pakistan Institute of Medical Sciences, Islamabad. Basic profile, family history, and physical activity were recorded through a predesigned questionnaire, dietary intake through seven days Food Diary and Food Frequency Questionnaire. Blood pressure and selected clinical signs and symptoms were recorded. Anthropometric measurements included mid-upper arm circumference (MUAC), body mass index (BMI), waist circumference (WC), waist-and-hip ratio (WHR), waist-to-height ratio (WHtR), and conicity index. Lab parameters included fasting blood glucose, HbA1c, insulin levels, and lipid profile. Homeostatic model assessment of insulin resistance (HOMA-IR) was computed to assess insulin resistance. Results Almost all parameters related to MetS were higher than normal. The prevalence of MetS was 59.7%. BMI, MUAC, and WHtR were independently associated with HOMA-IR, but WC, WHR, and the conicity index had no relationship MetS indicators. Conclusion The prevalence rate of MetS was found to be 59.7% in newly diagnosed T2DM patients. MUAC was found to be a better parameter for the diagnosis of central obesity and insulin resistance in the selected population.
Risks and benefits of psilocybin use in people with bipolar disorder: An international web-based survey on experiences of ‘magic mushroom’ consumption
Authors: Morton Emma , Sakai Kimberly , Ashtari Amir , Pleet Mollie , Michalak Erin E , Woolley Josh 
Published: December 2022

Background: Psilocybin, the primary psychoactive component of psychedelic ‘magic mushrooms’, may have potential for treating depressive symptoms, and consequent applications for bipolar disorder (BD). Knowledge of the risks and benefits of psilocybin in BD is limited to case studies. Aim: To support the design of clinical trials, we surveyed experiences of psilocybin use in people with BD. Methods: An international web-based survey was used to explore experiences of psilocybin use in people with a self-reported diagnosis of BD. Quantitative findings were summarised using descriptive statistics. Qualitative content analysis was used to investigate free-text responses, with a focus on positive experiences of psilocybin use. Results: A total of 541 people completed the survey (46.4% female, mean 34.1 years old). One-third (32.2%; n = 174) of respondents described new/increasing symptoms after psilocybin trips, prominently manic symptoms, difficulties sleeping and anxiety. No differences in rates of adverse events overall were observed between individuals with BD I compared to BD II. Use of emergency medical services was rare ( n = 18; 3.3%), and respondents (even those who experienced adverse effects) indicated that psilocybin use was more helpful than harmful. Quantitative findings elaborated on perceived benefits, as well as the potential for psilocybin trips to contain both positively and negatively received elements. Conclusions: The subjective benefits of psilocybin use for mental health symptoms reported by survey participants encourage further investigation of psilocybin-based treatments for BD. Clinical trials should incorporate careful monitoring of symptoms, as data suggest that BD symptoms may emerge or intensify following psilocybin use.
Effects of intracoronary low-dose prourokinase administration on ST-segment elevation in patients with myocardial infarction and a high thrombus burden: a randomized controlled trial
Authors: Cao Mingkun , Wang Zhiyong , Meng Xiujie , Xu Zhiru , Gao Jiangfeng , Zhu Wangliang , Yu Suhua , Zhang Haijun 
Published: December 2022

Objective To evaluate the efficacy and safety of low-dose prourokinase (pro-UK) administration during primary percutaneous coronary intervention (PCI) for the treatment of acute ST-segment elevation myocardial infarction (STEMI) in patients with a high thrombus burden. Methods A prospective, randomized controlled trial was conducted at the Inner Mongolia People’s Hospital, China. Patients with STEMI and a high thrombus burden who underwent thrombus aspiration and primary PCI were randomly allocated to pro-UK administration or control groups. The primary endpoint was corrected thrombolysis in myocardial infarction (TIMI) frame count (CTFC). Results There were no significant differences in the baseline demographics or clinical characteristics of the two groups. The CTFC, tissue myocardial perfusion grade, ST-segment resolution, and myocardial blush grade of the pro-UK group were significantly better than those of the control group. In addition, after 30 days of follow-up, the pro-UK group had better cardiac function and perfusion than the control group. There were no differences in the clinical outcomes or incidence of hemorrhage. Conclusions Intracoronary low-dose pro-UK improves myocardial perfusion and cardiac function in patients with a high thrombus burden. Major hemorrhages still occur in patients administered pro-UK, but are no more frequent. Study registration: Chinese Clinical Trial Registry (ChiCTR1900022290).
Effect of artificial aging on 3-point bending behavior of glass fiber/epoxy composites
Authors: Kosedag Ertan 
Published: December 2022

This study looked into how artificial aging affected the mechanical behavior of composites made of glass fiber reinforced polymer (GFRP). In this context, GFRP composites were produced by vacuum infusion method and artificially aged in the aging cabinet. Three different composite specimen types were tested. These are unaged samples aged 750 h and aged 1500 h. Three-point bending tests were performed to determine the mechanical properties. The absorbed energies of the samples were determined and the maximum bending stresses were calculated. The maximum contact force and sample displacements were also determined. In addition, the damage areas of the samples were examined optically and the changes that occurred with the aging time were determined. Finally, SEM images were taken to observe the changes in the internal structure of the aging and non-aging samples. According to results, as the sample aged, a decrease was observed in the energy values absorbed by the composite samples. In addition, as the aging time increased, it was determined that there was a spread in the damage area and more visible fiber breaks occurred. The increase in the aging time caused a decrease in the stiffness of the composite specimen, worsened its mechanical properties, and increased matrix damage.
The burden of TB/HIV co-infection among clients attending DOTs clinic in a tertiary centre in Southwestern, Nigeria: A 5-year retrospective study
Authors: Temitayo-Oboh Abiola Oluwatoyin , Sherif Azees Ayotunde , Ohunene Amin Jamila , Omobuwa Olubukunola 
Published: December 2022

Background: Tuberculosis (TB) and human immunodeficiency virus (HIV) are closely correlated and continue to cause deleterious effects in co-infected patients. This study aimed to determine the prevalence and associated factors of TB/HIV co-infection among directly observed treatment short-course (DOTs) clinic clients in Ogun State, Nigeria. Methods: The TB register and treatment cards of patients that visited the DOTs centre in Federal Medical Centre Abeokuta between January 2015 and December 2019 were reviewed. Results: A total of 726 TB patients’ records were reviewed, among which 186 (22.5%) were co-infected with HIV. TB/HIV co-infection was significantly associated with the ⩽19 years age group 54 (37.2%), females 85 (26.7%), divorced and separated 8 (34.8%), rural residents 18 (34.0%), those who had no formal education 53 (39.8%) and the unemployed 63 (31.7%). Gender and educational status remained significant predictors of TB/HIV co-infection after adjustment for confounding factors. Discussion: Gender-sensitive programming and interventions geared towards improving knowledge of TB and HIV using a wide array of approaches should be considered.