bluuebunny/crossref_metadata_2025_split huggingface dataset:
SUMOylation of Dorsal attenuates Toll/NF-κB signaling
Authors: Hegde Sushmitha , Sreejan Ashley , Gadgil Chetan J , Ratnaparkhi Girish S 
Published: May 2022

Abstract
In Drosophila, Toll/NF-κB signaling plays key roles in both animal development and in host defense. The activation, intensity, and kinetics of Toll signaling are regulated by posttranslational modifications such as phosphorylation, SUMOylation, or ubiquitination that target multiple proteins in the Toll/NF-κB cascade. Here, we have generated a CRISPR-Cas9 edited Dorsal (DL) variant that is SUMO conjugation resistant. Intriguingly, embryos laid by dlSCR mothers overcome dl haploinsufficiency and complete the developmental program. This ability appears to be a result of higher transcriptional activation by DLSCR. In contrast, SUMOylation dampens DL transcriptional activation, ultimately conferring robustness to the dorso-ventral program. In the larval immune response, dlSCR animals show an increase in crystal cell numbers, stronger activation of humoral defense genes, and high cactus levels. A mathematical model that evaluates the contribution of the small fraction of SUMOylated DL (1–5%) suggests that it acts to block transcriptional activation, which is driven primarily by DL that is not SUMO conjugated. Our findings define SUMO conjugation as an important regulator of the Toll signaling cascade, in both development and host defense. Our results broadly suggest that SUMO attenuates DL at the level of transcriptional activation. Furthermore, we hypothesize that SUMO conjugation of DL may be part of a Ubc9-dependent mechanism that restrains Toll/NF-κB signaling.
Optimal scheduling of building integrated energy systems using an improved ant lion algorithm
Authors: Wei Liming , Xv Shuo 
Published: May 2022

Abstract
In order to deal with the increasingly severe energy shortage problem, to find new energy solutions and to alleviate the dual pressure of domestic energy and environment, building a new type of multi-energy complementary power system has become one of the hot issues in recent years. This paper presents an optimal scheduling model of building integrated energy system (BIES) based on the comprehensive utilization of electricity, heat and gas. Based on the traditional combined cooling, heating, and power (CCHP) system, this model adds wind power and photoelectric renewable energy power generation systems, ground source heat pump system and energy storage system. Then, taking the environmental cost and system operation and maintenance cost as the objective function, it is solved by using the improved multi-objective ant lion algorithm based on differential evolution. Finally, a building in Northeast China is taken as an example to verify the simulation. The simulation results show that the optimal scheduling model of building integrated energy system proposed in this paper can promote the consumption of renewable energy such as wind power and photoelectric, realize the peak cutting and valley filling of power load, effectively reduce the economic operation cost of the system, reduce carbon emissions and effectively solve the problem of environmental pollution to a certain extent.
Identification and Quantitative Analysis of 2-Fluoromethamphetamine and Its Metabolites in Human Urine
Authors: Ishii Ayumu , Sato Kazuki , Kusakabe Kosuke , Kato Noriyuki , Wada Takeshi 
Published: May 2022

AbstractVarious synthetic drugs have appeared over the past years across the world, and phenethylamine derivatives are among them; indeed, aromatic fluoro analogs of methamphetamine and amphetamine have been in the illicit drug market since the early 2000s. Although they are currently widely abused across the world, little information is available on their metabolism and toxicology. Recently, we came across an alleged 2-fluoromethamphetamine (2-FMA) drug abuse case. The urine obtained from the alleged abuser was analyzed as part of a criminal investigation. 2-FMA, 2-fluoroamphetamine (2-FAP) and some related compounds were detected by liquid chromatography–tandem mass spectrometry. In forensic science, both an “unchanged” drug and its metabolite(s) need to be detected in urine to verify the illicit drug use. Notably, the detection of 2-FAP, which is a plausible 2-FMA metabolite, is insufficient as evidence of 2-FMA use because 2-FAP is widely available and may be present as such in taken liquids. In this study, we synthesized analytical standards for N-hydroxy 2-FMA (N-OH-2-FMA) and two diastereomers of 2-fluoroephedrine, which are plausible metabolites of 2-FMA. Using these standards, the urine specimen was found to contain N-OH-2FMA and one diastereomer of 2-fluoroephedrine; moreover, the concentrations of these compounds were successfully determined. The results of our study suggest that N-hydroxylation and aliphatic hydroxylation are the characteristic metabolic pathways of 2-FMA compared with that of methamphetamine. This evidence indicates that both N-OH-2-FMA and 2-fluoroephedrine are plausible candidates as analytical targets for drug-use certification in forensic science.
Sculpture, Faith, and the Many Worlds of Victorian Sculpture: W. F. Woodington, Genesis (1862)
Authors: Nichols Kate 
Published: May 2022

Abstract
This roundtable comment piece raises questions about the significance of materials, subject matter and form, and location and display to interpretations of W. F. Woodington’s 1862 Genesis panel at St Paul’s Cathedral. The panel was commissioned as an adjunct to the Wellington Memorial, and depicts the conclusion of the first military engagement in the Bible, the Battle of the Vale of Siddim. It features 18 human figures, three sheep, and two cows, and is inscribed with a passage from Genesis 14. 20. My comment piece reconceptualizes the panel as an assemblage bringing together many worlds, human and non-human, alongside the worlds of faith which were the impetus for the roundtable. It brings together biblical subject matter with the commemoration of military heroes; Italian marble quarry workers; the racially charged material of white marble; memories of sheep on their way to slaughter at Smithfield market; archaeological discoveries; the figure of Sodom in Victorian culture, and classical sculptural form. It asks how these varied geographies, time periods, and contributors to this object, human and non-human, might shift or mediate our understanding of this frieze as something more than an adjunct to a memorial to a military hero.
Serosal involvement in adult-onset Still’s disease: A multicentre and retrospective study
Authors: Li Yixuan , Guo Ruru , Li Wenjing , Feng Jiaqi , Jin Yuyang , Li Jia , Lu Liangjing , Feng Xuebing , Chen Xiaoxiang 
Published: May 2022

ABSTRACT

Objectives
This study evaluated the characteristics of serosal involvement in adult-onset Still’s disease (AOSD).

Methods
Patients meeting the Yamaguchi classification criteria were classified into AOSD with and without serosal involvement according to their manifestations and sonography/radiography. Clinical data was retrospectively reviewed from 102 patients with AOSD in two centres.

Results
Forty-two patients (41.2%) had serosal involvement. The frequencies of pulmonary infiltrate and impaired liver function were significantly higher in patients with serosal involvement (p = .002 and p = .007, respectively), who also had a higher modified systemic score (p = .009). In addition, the percentages of CD3+ T cells (p &lt; .001) and, especially, the CD8+ T cells (p = .004) were significantly increased in the peripheral blood of AOSD patients with serosal involvement. Notably, patients with serosal involvement were more likely to develop macrophage activation syndrome (p = .047) and a chronic pattern (p = .016) during the follow-up.

Conclusions
Patients with serosal involvement demonstrated the more severe disease activity and different immune phenotypes; these patients were more likely to develop macrophage activation syndrome, and they may require more aggressive treatment at an early time to control their systemic inflammation.
The circadian clock mutantlhy cca1 elf3paces starch mobilization to dawn despite severely disrupted circadian clock function
Authors: Alexandre Moraes Thiago , Mengin Virginie , Peixoto Bruno , Encke Beatrice , Krohn Nicole , Höhne Melanie , Krause Ursula , Stitt Mark 
Published: May 2022

AbstractMany plants, including Arabidopsis (Arabidopsis thaliana), accumulate starch in the daytime and remobilize it to support maintenance and growth at night. Starch accumulation is increased when carbon is in short supply, for example, in short photoperiods. Mobilization is paced to exhaust starch around dawn, as anticipated by the circadian clock. This diel pattern of turnover is largely robust against loss of day, dawn, dusk, or evening clock components. Here, we investigated diel starch turnover in the triple circadian clock mutant lhy cca1 elf3, which lacks the LATE ELONGATED HYPOCOTYL and the CIRCADIAN CLOCK-ASSOCIATED1 (CCA1) dawn components and the EARLY FLOWERING3 (ELF3) evening components of the circadian clock. The diel oscillations of transcripts for the remaining clock components and related genes like REVEILLE and PHYTOCHROME-INTERACING FACTOR family members exhibited attenuated amplitudes and altered peak time, weakened dawn dominance, and decreased robustness against changes in the external light–dark cycle. The triple mutant was unable to increase starch accumulation in short photoperiods. However, it was still able to pace starch mobilization to around dawn in different photoperiods and growth irradiances and to around 24 h after the previous dawn in T17 and T28 cycles. The triple mutant was able to slow down starch mobilization after a sudden low-light day or a sudden early dusk, although in the latter case it did not fully compensate for the lengthened night. Overall, there was a slight trend to less linear mobilization of starch. Thus, starch mobilization can be paced rather robustly to dawn despite a major disruption of the transcriptional clock. It is proposed that temporal information can be delivered from clock components or a semi-autonomous oscillator.
Contributions of species shade tolerance and individual light environment to photosynthetic induction in tropical tree seedlings
Authors: Kang Huixing , Tomimatsu Hajime , Zhu Ting , Ma Yixin , Wang Xiruo , Zhang Yan , Tang Yanhong 
Published: May 2022

Abstract
It has long been debated whether tree leaves from shady environments exhibit higher photosynthetic induction efficiency (IE) than those from sunny environments and how the shade tolerance of tree species and the light environment of leaves contribute to the dynamics of photosynthesis. To address these questions, we investigated leaf photosynthetic responses to simulated changes of light intensity in seedlings of six tree species with differential shade tolerance. The seedlings were growing under different light environments in a lowland tropical forest. We proposed an index of relative shade tolerance (RST) to assess species-specific capacity to tolerate shade, and we quantified the light environment of individual leaves by the index of daily light integral (DLI), the averaged daily total light intensity. We obtained the following results. Photosynthetic IE, which is the ratio of the achieved carbon gain to the expected carbon gain, was significantly higher for species with a higher RST than for that with a lower RST. The impacts of light environment on the IE of individual leaves within the same species varied largely among different species. In the three species with relatively low RST, the IE of individual leaves decreased at higher DLIs when DLI &lt; 10 mol m−2 d−1. Seedlings with high initial stomatal conductance before induction (gs50) possessed a higher IE than those with low gs50 from the same species. A trade-off existed between IE and steady-state photosynthetic rates. These results suggest a complex interaction between the shade tolerance of species and the light environments of individual leaves for photosynthetic induction and provide new insights into the adaptation strategy for understory seedlings under sunfleck environments.
Data-driven readiness: A preliminary report on cataloging best practices in military civilian partnerships
Authors: Gurney Jennifer M. , John Sarah K. , Whitt Edward H. , Slinger Bryce J. , Luan William P. , Lindly Jamie , Graybill Johnathan Christopher , Bailey Jeffrey A. 
Published: May 2022

BACKGROUND
Between conflicts, many of the combat casualty care lessons learned are lost as the nation shifts priorities and providers leave the military. Solutions are needed to bridge the knowledge gap created by interwar periods. One of the foremost solutions is partnerships between civilian trauma centers and the military health system. Over the past two decades, a myriad of military-civilian partnerships (MCPs), which vary in their composition, duration, and focus, was created. The objective of this report is to describe the initial attempt of the Department of Defense to catalog existing MCPs to inform both civilian and military stakeholders. This initial catalog is intended as a reference to aid in future MCP development and facilitate the synchronization of efforts to improve trauma care delivery and readiness.

METHODS
Using methodology from the Institute of Defense Analysis, the total number of eligible trauma centers in the United States was determined. The Institute of Defense Analysis determined eligibility-based American College of Surgeons Trauma Center verification or state trauma center designation. Each military service provided their list of MCPs, which were categorized. Military-civilian partnerships were cataloged by various characteristics and program components. Key variables include number and type of personnel trained, duration of training, and focus, for example, team versus individual focused and training versus maintaining proficiency focused.

RESULTS
A total of 1,139 hospitals in the United States are potentially eligible for MCPs. There are at least 87 unique partnerships; the majority are part-time sustainment MCPs. The Air Force has the largest number of providers in MCPs. There are many challenges to maintain accurate and up to date data on MCPs.

CONCLUSION
With the collated information, the Defense Health Agency, military services, special operations community, and civilian partners will be better empowered to optimize the readiness value of their programs and better prepare our military medical providers for the nation's and military's future needs.
Mechanisms of knowledge workers’ adaptive perfectionism on taking charge
Authors: Wei Caiyun , Zhang Lanxia 
Published: May 2022

Purpose
This study aims to explore the mechanisms of adaptive perfectionism on employees’ taking charge (TC), the mediating role of work family enrichment and the moderating role of perceived organizational support (OS) in the relationship between adaptive perfectionism and employees’ TC.

Design/methodology/approach
This study is based on 305 knowledge workers working in diverse organizations in China to examine the hypotheses.

Findings
The results showed that adaptive perfectionism had a significant positive effect on employees’ TC. Both directions of work-family enrichment (WFE) and family-work enrichment (FWE) play a mediating role between adaptive perfectionism and employees’ TC. Perceived OS moderates the relationship between WFE/FWE and employees’ TC. Perceived OS moderates the indirect effects of adaptive perfectionism on employees’ TC through WFE and FWE.

Originality/value
This study explores the impact of adaptive perfectionism on employees’ TC, expands the scope of existing perfectionism research, enriches the research on adaptive perfectionism outcome variables and provides evidence and reference for follow-up research.
Modelling of low-speed magnetic gear with viscose ferrofluid
Authors: Mateev Valentin , Marinova Iliana 
Published: May 2022

Purpose
In this paper, a computational model of a coaxial magnetic gear (MG) design with viscose ferrofluid between rotors is proposed. Viscose ferrofluid is used to decrease the magnetic reluctance and therefore creates higher magnetic torque. However, viscose friction of ferrofluid is undesirable and must be minimised in this particular application. MG is supposed to operate under low rotational speeds, where the dynamic viscose friction is very low, and the effects of the viscose ferrofluid over the MG’s efficiency must be estimated. The paper aims to analyze the performance of MG with viscose ferrofluid and to estimate the MG efficiency by computational model using finite element method (FEM).

Design/methodology/approach
An MG design with viscose ferrofluid between the outer low-speed rotor and modulating steel segments was modelled as a coupled transient magnetic field problem and a kinematic model with viscous friction coefficients derived from a previously computed fluid dynamics model.

Findings
The proposed computational implementation is suitable for homogeneous magnetic fluid modelling in electromagnetic actuators and rotational machines. The results regarding power and torque transmission of MG were obtained by coupled finite element modelling. The efficiency of MG significantly decreased due to ferrofluid friction.

Originality/value
The described MG design with viscose ferrofluid is a novel device with new operational characteristics, and new results for the effects of viscose ferrofluid friction in the outer magnetic field over the MG efficiency are estimated.
Human and contextual factors influencing cyber-security in organizations, and implications for higher education institutions: a systematic review
Authors: AL-Nuaimi Maryam Nasser 
Published: May 2022

Purpose
A research line has emerged that is concerned with investigating human factors in information systems and cyber-security in organizations using various behavioural and socio-cognitive theories. This study aims to explore human and contextual factors influencing cyber security behaviour in organizations while drawing implications for cyber-security in higher education institutions.

Design/methodology/approach
A systematic literature review has been implemented. The reviewed studies have revealed various human and contextual factors that influence cyber-security behaviour in organizations, notably higher education institutions.

Research limitations/implications
This review study offers practical implications for constructing and keeping a robust cyber-security organizational culture in higher education institutions for the sustainable development goals of cyber-security training and education.

Originality/value
The value of the current review arises in that it presents a comprehensive account of human factors affecting cyber-security in organizations, a topic that is rarely investigated in previous related literature. Furthermore, the current review sheds light on cyber-security in higher education from the weakest link perspective. Simultaneously, the study contributes to relevant literature by gaining insight into human factors and socio-technological controls related to cyber-security in higher education institutions.
Man vs machine: how artificial intelligence in banking influences consumer belief in financial advice
Authors: Northey Gavin , Hunter Vanessa , Mulcahy Rory , Choong Kelly , Mehmet Michael 
Published: May 2022

PurposeThis research set out to examine how financial advice provided by a human advisor (vs robo-advisor) influences investment intentions in a retail banking context.Design/methodology/approachIn two experiments, between-subjects experimental designs were employed to test the primary hypothesis and identify the underlying causal mechanisms that influence consumer investment decisions.FindingsThe results from two experiments indicate consumers have more belief in financial advice provided by a human financial advisor (vs robo-advisor), when the level of involvement is high. The authors also identify customer belief in the information and the customer's perception of the bank's “customer focus” as the causal mechanisms that have downstream effects on investment intentions.Originality/valueThis research is the first to examine how financial advice received from a human advisor (vs robo-advisor) influences investment intentions in a retail banking context. Furthermore, this research identifies high involvement as a key boundary condition moderating the effects on investment intention and identifies consumer belief in the advice, as well as the bank's perceived level of customer focus as the causal mechanisms influencing investment intentions.
Building performance analysis for optimizing the energy consumption of an educational building
Authors: Islam Md Hamidul , Safayet Md. Abu , Al Mamun Abdullah 
Published: May 2022

PurposeIn response to rising energy prices and growing environmental concerns, there is a growing demand for environmentally friendly building facilities. This study investigates optimizing energy consumption and improves the level of accuracy when selecting suitable materials and components with minimal impact on the overall energy consumption of buildings.Design/methodology/approachThis study was carried out from the perspective of an educational building's energy simulation, using a validated building energy analysis tool Green Building Studio (GBS). There were eight parameters analyzed considering at least two connected variables without measuring the initial building configuration. After that, Autodesk Revit and Insight 360 were used to make similar scenarios of the best performance selections so that the general results could be compared and the initial hypothesis could be proven.FindingsIn this study, the initial building analysis showed that there was an annual energy use of 139 kBtu/sf and the estimated carbon emissions were about 156 tons/yr. After the parametric analysis, the maximum energy saving was about 32.38%, considering the best performance scenario with a reduction of CO2 emissions of around 28.85%.Originality/valueThe outcome of this study will help Bangladeshi architect/designers to make appropriate decisions regarding the selection of suitable building materials and components at the initial stage of any project in terms of the energy consumption aspects. In addition, energy-efficient buildings provide cleaner combustion and better circulation than traditional buildings, that is why they reduce indoor air pollution, maintaining a safe, healthy and sustainable environment for future generations.