bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of fungal dynamic changes in the natural fermentation broth of ‘Kyoho’ grapes based on high-throughput sequencing
Authors: Zhao Wenjuan , Zhang Zhiming , Gao Yuhong , Liu Xiaozhen , Du Chaojin , Ma Fuxian , Wang Sujie , Shi Wanyuan , Yang Yanping , Deng Ruyou , Zhang Hanyao 
Published: February 2022

Abstract
The ‘Kyoho’ grape (Vitaceae, Plantae) has large ears, plenty of flesh, and rich nutrition, and is planted across a large area in China. There are few reports on this variety in winemaking, especially on the dynamic changes of fungi in the wine fermentation broth. In this study, we used the ‘Kyoho’ grapes as raw materials and adopted a high throughput to analyze dynamic changes in fungal species composition of the natural fermentation broth at four time points: day one (D1P), day three (D3P), day five (D5P), and day fifteen (D15P). Changes in fungal metabolic pathways and the dynamic changes of dominant yeast were also analyzed. A total of 78 families, 110 genera, and 137 species were detected, in the natural fermentation broth samples. The control check (CK) had 49 families, 60 genera, and 72 species. A total of 66 differential metabolic pathways were enriched; of those 66, 41 pathways were up-regulated compared to CK, such as pyrimidine deoxyribonucleotides biosynthesis from CTP (PWY 7210), CDP-diacylglycerol biosynthesis I (PWY 5667), and chitin degradation to ethanol (PWY 7118). Changes in fungal metabolic pathways were in line with the dynamic changes of dominant yeast species in the whole process of fermentation. Pichia kluyveri , P. membranifaciens , and Citeromyces matritensis are the dominant species in the later stages of natural fermentation. These yeast species may play vital roles in the ‘Kyoho’ wine industry in the future.
Gut microbiota transplantation drives the adoptive transfer of colonic genotype-phenotype characteristics between mice lacking catestatin and their wild type counterparts
Authors: González-Dávila Pamela , Schwalbe Markus , Danewalia Arpit , Wardenaar René , Dalile Boushra , Verbeke kristin , Mahata Sushil , Aidy Sahar El 
Published: February 2022

Abstract
Background
The gut microbiota is in continuous interaction with the intestinal mucosa via metabolic, neuro-immunological, and neuroendocrine pathways. Disruption in levels of antimicrobial peptides produced by the enteroendocrine cells, such as catestatin, has been associated with changes in the gut microbiota and imbalance in intestinal homeostasis. However, whether the changes in the gut microbiota have a causational role in intestinal dyshomeostasis has remained elusive.
Results
To this end, we performed reciprocal fecal microbial transplantation in wild-type mice and mice with a knockout in the catestatin coding region of the chromogranin-A gene (CST-KO mice). Combined microbiota phylogenetic profiling, RNA sequencing, and transmission electron microscopy were employed. Fecal microbiota transplantation from mice deficient in catestatin (CST-KO) to microbiota-depleted wild-type mice induced transcriptional and physiological features characteristic of a distorted colon in the recipient animals, including impairment in tight junctions, as well as an increased collagen area fraction indicating colonic fibrosis. In contrast, fecal microbiota transplantation from wild-type mice to microbiota-depleted CST-KO mice reduced collagen fibrotic area, restored disrupted tight junction morphology, and altered fatty acid metabolism in recipient CST-KO mice.
Conclusions
This study provides a comprehensive overview of the murine metabolic- and immune-related cellular pathways and processes that are co-mediated by the fecal microbiota transplantation and supports a prominent role for the gut microbiota in the colonic distortion associated with the lack of catestatin in mice. Overall, the data show that the gut microbiota may play a causal role in the development of features of intestinal inflammation and metabolic disorders, known to be associated with altered levels of catestatin and may, thus, provide a tractable target in the treatment and prevention of these disorders.
Yttrium doped ZnO nanoparticles towards corrosion protection epoxy nanocomposite coatings in neutral and acidic medium
Authors: S Johnkennadyvethanathan , R Aboorvakani , K.U. Madhu 
Published: February 2022

Abstract
In the present study, synthesized pure and Yttrium (0.5, 1.0, 1.5, 2.0 and 2.5 mM) doped Zinc Oxide (YZO) nanoparticles by chemical precipitation method. The size effect of Zinc oxide nanoparticle under Yttrium acetate precursor molar concentration were investigated by various characterization techniques. X-ray diffractogram asserts the hexagonal wurtzite structure of ZnO nanoparticles. The average crystallite size was found to be 22 − 17 nm. The FTIR and Raman spectrum inscribed the chemical composition and vibrational frequencies of the synthesized samples. The hexagonal shape, surface morphology, particle size and elemental composition of the samples were analysed by FESEM, HRTEM and EDAX. The optical bandgap energy was estimated in the range of 3.148–3.175 eV. PL spectra of yttrium doped ZnO nanoparticles at various concentration exhibit a strong UV emission band and green emission band. The anticorrosive property of nanoscopic size (17 nm) YZO/epoxy nanocomposite was studied by electrochemical impedance spectroscopy (EIS) technique in both neutral and acidic medium. Epoxy/YZO nanocomposites were prepared using different loadings (0.05, 0.10 and 0.15 wt %) of yttrium doped ZnO nanoparticles. Epoxy/YZO nanocomposites were applied on mild steel substrates. The acquisition of yttrium doped ZnO into the plain epoxy coating materially increased the charge transfer resistance Rct by 3.5 times in oxalic acid solution as against epoxy/ZnO coating. The synthesized sample has also displayed excellent antimicrobial activity against gram positive and gram-negative bacteria. This encapsulates that the YZO nanoparticles are a potential eco-friendly, antibacterial and anti-corrosive fillers in coat on mild steel.
Primary Extranodal Diffuse Large B-Cell Lymphoma In The Rituximab Era: A Single Center, Retrospective Analysis
Authors: Zhao Jinrong , Zhang Wei , Zhou Daobin , Zhang Yan , Wang Wei , Wei Chong , Zhao Danqing , Ruan Jing , Wang Zi , Zhuang Zhe 
Published: February 2022

Abstract
Background: A large proportion of diffuse large B-cell lymphoma originates from extranodal sites. The outcomes of Chinese patients with primary extranodal diffuse large B-cell lymphoma (PE-DLBCL) have been greatly improved. Methods: Clinical features and outcomes of 197 patients newly diagnosed with PE-DLBCL from January 2015 to December 2020 were analyzed retrospectively. Results: (1) Gastrointestinal tract (34%) involvement ranked first, followed by central nervous system (CNS) and intraocular (31.5%), nose/nasopharynx (7.1%), breast (5.1%), testis (3.6%) and others. (2) The 3-year overall survival (OS) rate for the entire group was 81%; The 3-year OS rate of PE-DLBCL with CNS and vitreoretinal involvement was 79%. (3) In univariate analysis of PE-DLBCL, Ann Arbor stage, evaluated LDH, IPI>2 and complete remission (CR) were significantly related to survival. The lack of CR was the only independent adverse prognostic factor in OS (p = 0.000; HR = 4.659). (4) Lugano stage and treatment response were independent prognostic factors for primary gastrointestinal DLBCL. Conclusion: This is a single-center report of PE-DLBCL in China in the past 5 years with a fairly excellent outcome and a large scale. The treatment response of patients is significantly better than before, especially in patients with CNS and vitreoretinal involvement.
Neurocognitive evidence of enhanced implicit temporal processing in video game players
Authors: Foerster Francois , Chidharom Matthieu , Bonnefond Anne , Giersch Anne 
Published: February 2022

Abstract
Winning in action video games requires to predict timed events in order to react fast enough. In these games, the temporal structure of events is repetitive enough to develop implicit (automatic) preparation mechanisms. We compared action video game players (VGPs) and non-VGPs in a reaction time task involving both implicit time preparations and explicit (conscious) temporal attention cues. Participants were immersed in virtual reality and instructed to respond to a visual target appearing at variable delays after a warning signal (WS). In half of the trials, an explicit cue indicated when the target would occur after the WS. Behavioral, oculomotor and EEG data consistently indicate that, compared with NVGPs, VGPs better prepare in time using implicit mechanisms. This sheds light on the neglected role of implicit timing in VGPs and related electrophysiological mechanisms. The results further suggest that game-based interventions may help remediate timing alterations found in psychiatric populations.
Improvement in image quality in obese patients by using a new x-ray tube and Deep Learning Image Reconstruction in Coronary Computed Tomography Angiography
Authors: Brunebjerg Anne-Sofie Horsted , Mørup Svea Deppe , Andersen Thomas Rueskov , Mohamed Roda Abdulkadir , Lambrechtsen Jess 
Published: February 2022

Abstract
Purpose: When performing coronary computed tomography angiography (CCTA) in obese patients, it is a challenge to obtain diagnostic image quality. Theoretically, higher tube currents improve image quality in obese patients by reducing noise, but this comes with an increased radiation as a trade-off. Deep learning image reconstruction (DLIR) is a technique that should reduce noise and improve image quality without the need of a higher radiation dose. This study assessed the impact of higher tube currents and DLIR on image quality, diagnostic utility, and noise. Methods: The study consisted of 51 symptomatic obese (BMI > 30 kg/m 2 ) patients with low to moderate risk of coronary artery disease (CAD). All patients underwent CCTA twice, first with the Revolution CT scanner and then with the upgraded Revolution Apex scanner with the ability to increase tube currents. Images were reconstructed using ASiR-V 50% and DLIR and evaluated by an observer using a Likert score. Results: Image quality was significantly improved with the Revolution Apex scanner and reconstruction with DLIR, resulting in an odds ratio of 1,23 (p = 0,017), and noise was significantly reduced by 41%. Diagnostic utility was also improved with 88% vs. 69% “diagnostic” image sets of those performed with Revolution Apex + DLIR and Revolution Apex/CT + ASiR-V, respectively. No significant differences were found between Revolution CT and Revolution Apex when reconstructing with ASiR-V. Conclusion: In obese patients, the combination of higher tube currents and reconstruction with DLIR significantly improves the subjective image quality and diagnostic utility and reduces noise.
College Squirrels Gone Wild? Using Sciurus Carolinensis Behavior To Assess The Ecosystem Value Of Urban Green Spaces
Authors: Kay Adam , Hughes Michael T. , Ammend Maddie G. , Granger Mckenzie R. , Hodge Jake J. , Mohamud Jamaal , Romfoe Ellie A. , Said Halima , Selden Liam , Welter Alex L. , Heinen-Kay Justa L. 
Published: February 2022

Abstract
Predicted rapid increases in urbanization in the face of accelerating biodiversity loss underscores the need for urban development that promotes rather than displaces native plants and animals. One approach for increasing urban biodiversity is through the development of “green infrastructure”. Although research has explored urban-rural gradients and the overall value of urban green infrastructure, few studies have investigated the habitat value for wildlife of different types of urban greenspace. Here, we use a well-established metric in ecology, giving up-densities (GUDs), to compare foraging costs for a common urban wildlife species, the eastern gray squirrel (Sciurus carolinensis), among three green infrastructure categories: municipal parks, college campuses, and residential yards. We found that GUDs for gray squirrels did not differ significantly among location categories after controlling for proximity to roads, but proximity to roads was associated with significantly higher GUDs in all locations. In an explicit test, we also found that both proximity to roads and traffic volume were associated with higher GUDs. We also found that maximum distance from roads was significantly higher for campuses and parks than for residential yards, indicating a greater proportion of the area of campuses and parks is “away from roads” compared to residential yards. Our results indicate that vehicle traffic may contribute significantly to an “urban landscape of fear” for gray squirrels and suggest that campus and park configurations that reduce road effects could improve habitat quality for squirrels and possibly other animals.
Impacts of abrupt temperature changes and warming hiatuses on water resources in the mid-and-low-latitude regions of the temperate continental-monsoon transition zone
Authors: Huang Xing , Ma Long , Liu Tingxi , Sun Bolin , Chen Yang , Qiao Zixu 
Published: February 2022

Abstract

The global climate has undergone significant changes in the past 100 years, yet the extent to which abrupt temperature changes (ATCs) and warming hiatuses (WHs) impact runoff remains unclear. This study used the water balance model (WBM) to quantitatively assess the impacts of climate change and human activities on the measured runoff at representative runoff stations in the mid-and-low-latitude regions of the temperate continental-monsoon transition zone and further analysed the impacts of ATCs and WHs on the runoff at the representative stations. The results show the following. The runoff in the study area decreased overall, and the runoff at five stations located in the northeast and west was essentially not impacted by human activities, while the runoff at seven stations in the central part of the study area was significantly impacted by human activities, with a maximum degree of impact of more than 70%. The average temperature of each basin in the study area underwent a significant abrupt increase in the 1990s, which had a negative driving effect on runoff, reducing the runoff depth by 1.92–2.98 mm. The runoff between Hailar and Halaqin in the central part of the study area was significantly impacted by human activities, with a maximum degree of impact of more than 70%. After removing the impact of human activities, evaporation tended to decrease after the abrupt temperature increase; i.e., an “evaporation paradox” phenomenon occurred in these regions. During this period, the amount of precipitation was stable, and the ATC increased the runoff by 0.27–11.74 mm; the runoff changes at the Yingluoxia and Zhengyixia stations in the west were only slightly impacted by human activities, and the ATC significantly increased the runoff, which reached 13.86 mm. In 2007, the average temperature in some basins experienced a WH, which had a relatively small impact on the runoff and a negative driving effect, reducing the runoff by 0.13–5.19 mm. In terms of the contribution to runoff changes around the ATC and WH, the contribution of temperature to runoff changes after the ATC was slightly greater after than that before the ATC, while the contribution of temperature to runoff changes before and after the WH did not exhibit a clear variation pattern.
Cost-Effectiveness of Mobile Health–Based Integrated Care for Atrial Fibrillation: Model Development and Data Analysis
Authors: Luo Xueyan , Xu Wei , Ming Wai-Kit , Jiang Xinchan , Yuan Quan , Lai Han , Huang Chunji , Zhong Xiaoni 
Published: February 2022

Background
Mobile health (mHealth) technology is increasingly used in disease management. Using mHealth tools to integrate and streamline care has improved clinical outcomes of patients with atrial fibrillation (AF).

Objective
The aim of this study was to investigate the potential clinical and health economic outcomes of mHealth-based integrated care for AF from the perspective of a public health care provider in China.

Methods
A Markov model was designed to compare outcomes of mHealth-based care and usual care in a hypothetical cohort of patients with AF in China. The time horizon was 30 years with monthly cycles. Model outcomes measured were direct medical cost, quality-adjusted life years (QALYs), and incremental cost-effectiveness ratio (ICER). Sensitivity analyses were performed to examine the robustness of the base-case results.

Results
In the base-case analysis, mHealth-based care gained higher QALYs of 0.0730 with an incurred cost of US $1090. Using US $33,438 per QALY (three times the gross domestic product) as the willingness-to-pay threshold, mHealth-based care was cost-effective, with an ICER of US $14,936 per QALY. In one-way sensitivity analysis, no influential factor with a threshold value was identified. In probabilistic sensitivity analysis, mHealth-based care was accepted as cost-effective in 92.33% of 10,000 iterations.

Conclusions
This study assessed the expected cost-effectiveness of applying mHealth-based integrated care for AF according to a model-based health economic evaluation. The exploration suggested the potential cost-effective use of mHealth apps in streamlining and integrating care via the Atrial fibrillation Better Care (ABC) pathway for AF in China. Future economic evaluation alongside randomized clinical trials is highly warranted to verify the suggestion and investigate affecting factors such as geographical variations in patient characteristics, identification of subgroups, and constraints on local implementation.
Digitally Supported Lifestyle Intervention to Prevent Type 2 Diabetes Through Healthy Habits: Secondary Analysis of Long-Term User Engagement Trajectories in a Randomized Controlled Trial
Authors: Lavikainen Piia , Mattila Elina , Absetz Pilvikki , Harjumaa Marja , Lindström Jaana , Järvelä-Reijonen Elina , Aittola Kirsikka , Männikkö Reija , Tilles-Tirkkonen Tanja , Lintu Niina , Lakka Timo , van Gils Mark , Pihlajamäki Jussi , Martikainen Janne 
Published: February 2022

Background
Digital health interventions may offer a scalable way to prevent type 2 diabetes (T2D) with minimal burden on health care systems by providing early support for healthy behaviors among adults at increased risk for T2D. However, ensuring continued engagement with digital solutions is a challenge impacting the expected effectiveness.

Objective
We aimed to investigate the longitudinal usage patterns of a digital healthy habit formation intervention, BitHabit, and the associations with changes in T2D risk factors.

Methods
This is a secondary analysis of the StopDia (Stop Diabetes) study, an unblinded parallel 1-year randomized controlled trial evaluating the effectiveness of the BitHabit app alone or together with face-to-face group coaching in comparison with routine care in Finland in 2017-2019 among community-dwelling adults (aged 18 to 74 years) at an increased risk of T2D. We used longitudinal data on usage from 1926 participants randomized to the digital intervention arms. Latent class growth models were applied to identify user engagement trajectories with the app during the study. Predictors for trajectory membership were examined with multinomial logistic regression models. Analysis of covariance was used to investigate the association between trajectories and 12-month changes in T2D risk factors.

Results
More than half (1022/1926, 53.1%) of the participants continued to use the app throughout the 12-month intervention. The following 4 user engagement trajectories were identified: terminated usage (904/1926, 46.9%), weekly usage (731/1926, 38.0%), twice weekly usage (208/1926, 10.8%), and daily usage (83/1926, 4.3%). Active app use during the first month, higher net promoter score after the first 1 to 2 months of use, older age, and better quality of diet at baseline increased the odds of belonging to the continued usage trajectories. Compared with other trajectories, daily usage was associated with a higher increase in diet quality and a more pronounced decrease in BMI and waist circumference at 12 months.

Conclusions
Distinct long-term usage trajectories of the BitHabit app were identified, and individual predictors for belonging to different trajectory groups were found. These findings highlight the need for being able to identify individuals likely to disengage from interventions early on, and could be used to inform the development of future adaptive interventions.

Trial Registration
ClinicalTrials.gov NCT03156478; https://clinicaltrials.gov/ct2/show/NCT03156478

International Registered Report Identifier (IRRID)
RR2-10.1186/s12889-019-6574-y
CULTURA, PATRIMÔNIO E TERRITÓRIOS DO VINHO
Authors: Medeiros Rosa Maria Vieira 
Published: February 2022

A vitivinicultura no Brasil já é uma realidade dada sua expansão e seu reconhecimento na produção de vinhos finos. A Indicação Geográfica (Indicação de Procedência, Denominação de Origem) obtidas em diversos territórios vitivinícolas brasileiros consolidou a importância dessa produção. No que tange a vitivinicultura, foi um processo construído pelo sentimento identitário dos imigrantes que chegaram ao Brasil, mais precisamente no Rio Grande do Sul, no século XIX. A expansão das áreas de produção em todo o território nacional vem ocorrendo com produção de qualidade e com competitividade em relação à produção vinícola internacional. Nesse sentido, busca-se entender a expressão da vitivinicultura como forma de preservar a memória, a cultura e o patrimônio do vinho no Brasil.
Feasibility study of palm oil boiler ash (POBA) as a partial replacement of sand in foamed concrete
Authors: Mohamed Yusof Mohamed Khatif Tawaf , Sharipudin Siti Shahidah , Mohammad Shahrul Nizam , Roslan Azmi , Michael Zeno , Shahrul Azhar Ilya Izyan , Zainal Abidin Nurrul Amilin 
Published: February 2022

A study was conducted to explore the effect of palm oil boiler ash (POBA) on foamed concrete by varying the percentage of POBA over sand quantities (0, 4, 8 and 12%). This paper primarily discusses the water absorption test, uniaxial compressive strength, and dry density findings. It indicates that substituting sand with POBA greatly enhances the strength of foamed concrete. When the quantity of POBA was raised up to 12% throughout all curing times, the compressive strength steadily increased in the range of 4.34–13.50 N·mm–2. Furthermore, the dry density of foamed concrete was shown to be directly related to the fraction of POBA in the mixture. The dry density of foamed concrete increases as the amount of POBA increases. Despite this, water absorption shown that increasing POBA increases water absorption percentage in foamed concrete from 7.4 to 10.4%. This is due to the fact that a composition with a high POBA percentage will generate more pores than a mixture with a low POBA percentage.