bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mass production-enabled computational spectrometers based on multilayer thin films
Authors: Kim Cheolsun , Ni Pavel , Lee Kang Ryeol , Lee Heung-No 
Published: March 2022

AbstractMultilayer thin film (MTF) filter arrays for computational spectroscopy are fabricated using stencil lithography. The MTF filter array is a 6 × 6 square grid, and 169 identical arrays are fabricated on a single wafer. A computational spectrometer is formed by attaching the MTF filter array on a complementary metal–oxide–semiconductor (CMOS) image sensor. With a single exposure, 36 unique intensities of incident light are collected. The spectrum of the incident light is recovered using collected intensities and numerical optimization techniques. Varied light sources in the wavelength range of 500 to 849 nm are recovered with a spacing of 1 nm. The reconstructed spectra are a good match with the reference spectra, measured by a grating-based spectrometer. We also demonstrate computational pinhole spectral imaging using the MTF filter array. Adapting a spectral scanning method, we collect 36 monochromatic filtered images and reconstructed 350 monochromatic images in the wavelength range of 500 to 849 nm, with a spacing of 1 nm. These computational spectrometers could be useful for various applications that require compact size, high resolution, and wide working range.
Temporospatial characterization of ventricular wall motion with real-time cardiac magnetic resonance imaging in health and disease
Authors: Li Yu Y. , Rashid Shams , Craft Jason , Cheng Yang J. , Schapiro William , Gliganic Kathleen , Yamashita Ann-Marie , Grgas Marie , Haag Elizabeth , Cao J. Jane 
Published: March 2022

AbstractCardiac magnetic resonance imaging (MRI) has been largely dependent on retrospective cine for data acquisition. Real-time imaging, although inferior in image quality to retrospective cine, is more informative about motion dynamics. We herein developed a real-time cardiac MRI approach to temporospatial characterization of left ventricle (LV) and right ventricle (RV) wall motion. This approach provided two temporospatial indices, temporal periodicity and spatial coherence, for quantitative assessment of ventricular function. In a cardiac MRI study, we prospectively investigated temporospatial characterization in reference to standard volumetric measurements with retrospective cine. The temporospatial indices were found to be effective for evaluating the difference of ventricular performance between the healthy volunteers and the heart failure (HF) patients (LV temporal periodicity 0.24 ± 0.037 vs. 0.14 ± 0.021; RV temporal periodicity 0.18 ± 0.030 vs. 0.10 ± 0.014; LV spatial coherence 0.52 ± 0.039 vs. 0.38 ± 0.040; RV spatial coherence 0.50 ± 0.036 vs. 0.35 ± 0.035; all in arbitrary unit). The HF patients and healthy volunteers were well differentiated in the scatter plots of spatial coherence and temporal periodicity while they were mixed in those of end-systolic volume (ESV) and ejection fraction (EF) from volumetric measurements. This study demonstrated the potential of real-time cardiac MRI for intricate analysis of ventricular function beyond retrospective cine.
PET/MRI-evaluated brown adipose tissue activity may be related to dietary MUFA and omega-6 fatty acids intake
Authors: Maliszewska Katarzyna , Adamska-Patruno Edyta , Miniewska K. , Bauer W. , Mojsak M. , Kretowski A. 
Published: March 2022

AbstractAn investigation of new ways to activate brown adipose tissue (BAT) is highly valuable, as it is a possible tool for obesity prevention and treatment. The aim of our study was to evaluate the relationships between dietary intake and BAT activity. The study group comprised 28 healthy non-smoking males aged 21–42 years. All volunteers underwent a physical examination and 75-g OGTT and completed 3-day food intake diaries to evaluate macronutrients and fatty acid intake. Body composition measurements were assessed using DXA scanning. An FDG-18 PET/MR was performed to visualize BAT activity. Brown adipose tissue was detected in 18 subjects (67% normal-weight individuals and 33% overweight/obese). The presence of BAT corresponded with a lower visceral adipose tissue (VAT) content (p = 0.04, after adjustment for age, daily kcal intake, and DXA Lean mass). We noted significantly lower omega-6 fatty acids (p = 0.03) and MUFA (p = 0.02) intake in subjects with detected BAT activity after adjustment for age, daily average kcal intake, and DXA Lean mass, whereas omega-3 fatty acids intake was comparable between the two groups. BAT presence was positively associated with the concentration of serum IL-6 (p = 0.01) during cold exposure. Our results show that BAT activity may be related to daily omega-6 fatty acids intake.
Effect of severity and cause of preoperative anemia on the transfusion rate after total knee arthroplasty
Authors: Kim Tae Woo , Park Hyung Jun , Chang Moon Jong , Kang Sang Yoon , Kang Kee Soo , Chang Chong Bum , Kang Seung-Baik 
Published: March 2022

AbstractThis study aimed to (1) evaluate the preoperative Hb cut-off value for transfusion after unilateral and bilateral staged (1 week apart) TKAs, respectively, and (2) determine whether cause of preoperative anemia can affect transfusion rate after TKA. A total of 951 patients who underwent TKA (unilateral: 605, bilateral staged: 346) from 2016 to 2019 were reviewed retrospectively. Patient demographics, comorbidities, preoperative Hb level, surgery types, and cause of anemia were evaluated as possible risk factors. The cut-off values for preoperative Hb level to reduce transfusion after TKA were evaluated in each surgery type. Preoperative Hb level, surgery type, and cardiac disease were identified as the risk factors for transfusion after TKA, and preoperative Hb levels of 11.8 (AUC 0.88) and 12.8 (AUC 0.76) were the cut-off values for transfusion after unilateral and staged bilateral TKAs, respectively. Although transfusion rate was higher in anemia with iron deficiency (ID) group than anemia without ID group, preoperative Hb level was also lower in anemia with ID group than anemia without ID group. Single use of preoperative Hb level with different cut-offs depending on the surgery types can be useful indicator for preoperative optimization regardless of cause of anemia.
Refractive errors in a large dataset of French children: the ANJO study
Authors: Guillon-Rolf Rébecca , Grammatico-Guillon Leslie , Leveziel Nicolas , Pelen Francois , Durbant Eve , Chammas Jimmy , Khanna Raoul K. 
Published: March 2022

AbstractUndetected refractive errors (REs) in children can lead to irreversible vision loss. This study aimed to show the proportions of REs in French children using cycloplegic refraction. Multicentre cross-sectional retrospective study including children with cycloplegic refraction and without associated ocular conditions from 2015 to 2018 in French eye clinics. The following data were collected: age, symptoms of eye strain, best-corrected visual acuity (BCVA), cycloplegic refraction. The analysis included 48,163 children (mean age: 7.75 years, range: 2 to 12 years). The proportion of each RE was as follows: emmetropia (− 0.50 < Spherical Equivalent (SE) ≤  + 2.0; 58.3%), hyperopia (+ 2.0 $$<$$
<
SE $$\le$$
≤
+5; 17.2%), myopia (− 6 $$\le$$
≤
SE $$\le$$
≤
− 0.50; 15.5%), high myopia (SE < − 6; 0.5%), high hyperopia (SE >  + 5; 3.6%), mixed astigmatism (4.9%). Anisometropia (SE difference ≥ 1.5) was found in 5.0%. Functional amblyopia in children attending primary school (aged over 6 years) was encountered in 2.7%. Symptoms of eye strain were frequent (70%) but not specific to any RE. REs are frequently found in French children and may remain undetected in the absence of symptoms of eye strain. Few studies have investigated REs in children using cycloplegic refraction, which has been shown to be the gold standard for RE assessment.
Bitumen and asphaltene derived nanoporous carbon and nickel oxide/carbon composites for supercapacitor electrodes
Authors: Mishra Dinesh , Zhou Rufan , Hassan Md. Mehadi , Hu Jinguang , Gates Ian , Mahinpey Nader , Lu Qingye 
Published: March 2022

AbstractAsphaltenes from bitumen are abundant resource to be transformed into carbon as promising supercapacitor electrodes, while there is a lack of understanding the impact from different fractions of bitumen and asphaltenes, as well as the presence of transition metals. Here, nanoporous carbon was synthesized from bitumen, hexane-insoluble asphaltenes and N,N-dimethylformamide (DMF)-fractionated asphaltenes by using Mg(OH)2 nanoplates as the template with in-situ KOH activation, and used as an supercapacitor electrode material. All of the carbon exhibited large surface area (1500–2200 m2 g−1) with a distribution of micro and mesopores except for that derived from the DMF-soluble asphaltenes. The pyrolysis of asphaltenes resulted in the formation of nickel oxide/carbon composite (NiO/C), which demonstrated high capacitance of 380 F g−1 at 1 A g−1 discharge current resulting from the pseudocapacitance of NiO and the electrochemical double layer capacitance of the carbon. The NiO/C composite obtained from the DMF-insoluble portion had low NiO content which led to lower capacitance. Meanwhile, the specific capacitance of NiO/C composite from the DMF-soluble part was lower than the unfractionated asphaltene due to the higher NiO content resulting in lower conductivity. Therefore asphaltenes derived from nickel-rich crude bitumen is suitable for the synthesis of nanoporous NiO/C composite material with high capacitance.
Expression of whole blood miR-126-3p, -30a-5p, -1299, -182-5p and -30e-3p in chronic kidney disease in a South African community-based sample
Authors: Motshwari Dipuo D. , George Cindy , Matshazi Don M. , Weale Cecil J. , Davids Saarah F. G. , Zemlin Annalise E. , Erasmus Rajiv T. , Kengne Andre P. , Matsha Tandi E. 
Published: March 2022

AbstractThe burden of chronic kidney disease (CKD) in Africa remains poorly characterized, due partly to the lack of appropriate diagnostic strategies. Although in recent years the diagnostic and prognostic utility of microRNAs (miRNAs) have gained prominence in the context of CKD, its value has not been evaluated in African populations. We investigated the expression of whole blood miRNAs (miR-126-3p, -30a-5p, -1299, -182-5p and -30e-3p) in a total sample of 1449 comprising of 13.3% individuals with CKD (stage 1–5) and 26.4% male participants, as well as the association of these miRNAs with prevalent CKD, in a community-based sample of South African adults. We used Reverse Transcription Quantitative Real-Time PCR (RT-qPCR) to analyze miRNA expression. There was an increased expression in whole blood miR-126-3p, -30a-5p, -1299 and -182-5p in individuals with CKD, compared to those without (all p ≤ 0.036), whereas miR-30e-3p showed no significant difference between the groups (p = 0.482). Only miR-126-3p, -182-5p and -30e-3p were independently associated with increased risk of CKD (all p ≤ 0.022). This study showed for the first time that there is a dysregulation of whole blood miR-126-3p, -30a-5p, -1299 and -182-5p in South Africans of mixed-ancestry with CKD. More research is needed to ascertain their role in CKD risk screening in African populations.
Application of choosing by advantages to determine the optimal site for solar power plants
Authors: Goh Hui Hwang , Li Chunyu , Zhang Dongdong , Dai Wei , Lim Chee Shen , Kurniawan Tonni Agustiono , Goh Kai Chen 
Published: March 2022

AbstractSolar energy is a critical component of the energy development strategy. The site selection for solar power plants has a significant impact on the cost of energy production. A favorable situation would result in significant cost savings and increased electricity generation efficiency. California is located in the southwest region of the United States of America and is blessed with an abundance of sunlight. In recent years, the state's economy and population have expanded quickly, resulting in an increased need for power. This study examines the south of California as a possibly well-suited site for the constructing large solar power plants to meet the local electricity needs. To begin, this article imposed some limits on the selection of three potential sites for constructing solar power plants (S1, S2, and S3). Then, a systematic approach for solar power plant site selection was presented, focusing on five major factors (economic, technological, social, geographical, and environmental). This is the first time that the choosing by advantages (CBA) method has been used to determine the optimal sites for solar power plant construction, with the possible sites ranked as S2 > S1 > S3. The results were then compared with traditional methods such as the multi-criteria decision-making method. The findings of this study suggest that the CBA method not only streamlines the solar power plant site selection process but also closely aligns with the objectives and desires of the investors.
Targeted metabolomics analysis of serum and Mycobacterium tuberculosis antigen-stimulated blood cultures of pediatric patients with active and latent tuberculosis
Authors: Magdalena Druszczynska , Michal Seweryn , Marta Sieczkowska , Magdalena Kowalewska-Pietrzak , Anna Pankowska , Magdalena Godkowicz , Rafał Szewczyk 
Published: March 2022

AbstractProfound tuberculosis (TB)-induced metabolic changes reflected in the blood metabolomic profile may provide an opportunity to identify specific markers of Mycobacterium tuberculosis infection. Using targeted liquid chromatography tandem mass spectrometry, we compared the levels of 30 small metabolites, including amino acids and derivatives, and small organic compounds in serum and M.tb antigen-stimulated whole blood cultures of active TB children, latent TB (LTBI) children, nonmycobacterial pneumonia (NMP) children, and healthy controls (HCs) to assess their potential as biomarkers of childhood TB. We found elevated levels of leucine and kynurenine combined with reduced concentrations of citrulline and glutamine in serum and blood cultures of TB and LTBI groups. LTBI status was additionally associated with a decrease in valine levels in blood cultures. The NMP metabolite profile was characterized by an increase in citrulline and glutamine and a decrease in leucine, kynurenine and valine concentrations. The highest discriminatory potential for identifying M.tb infection was observed for leucine detected in serum and kynurenine in stimulated blood cultures. The use of targeted metabolomics may reveal metabolic changes in M.tb-infected children, and the obtained results are a proof of principle of the usefulness of metabolites in the auxiliary diagnosis of TB in children.
Isotopic variability in tropical cyclone precipitation is controlled by Rayleigh distillation and cloud microphysics
Authors: Sun Chijun , Tian Lijun , Shanahan Timothy M. , Partin Judson W. , Gao Yongli , Piatrunia Natasha , Banner Jay 
Published: March 2022

AbstractTropical cyclones produce rainfall with extremely negative isotope values (δ18O and δ2H), but the controls on isotopic fractionation during tropical cyclones are poorly understood. Here we studied the isotopic composition of rainfall at sites across central Texas during Hurricane Harvey (2017) to better understand these processes. Rainfall δ18O trend towards more negative values as a result of Rayleigh distillation of precipitation-generating airmasses as they travel towards the center of the storm. Superimposed on these gradual changes are abrupt isotopic shifts with exceptionally low deuterium excess values. These appear to be controlled by microphysical processes associated with the passage of spiral rainbands over the sampling locations. Isotope-enabled climate modeling suggests that it may be possible to identify the signature of tropical cyclones from annually resolved isotopic proxy records, but will depend on the size of the storm and the proximity of the site to the core of the storm system.
Tunable third-order nonlinear optical effect via modifying Ti4(embonate)6 cage-based ionic pairs
Authors: Chen Guang-Hui , He Yan-Ping , Wang Zi-Rui , Li Qiao-Hong , Ma Zhi-Zhou , Zhang Jian 
Published: March 2022

The integration of Ti4L6 (L = embonate) cages and various N,N-chelated transition-metal cations into tightly packed structures accurately leads to high-performance materials with adjustable nonlinear optical (NLO) effects.
Optimal dispatch of integrated energy system considering integrated demand response resource trading
Authors: Wang Lei , Tao Zhengxuan , Zhu Liuzhu , Wang Xuli , Yin Chenxu , Cong Hao , Bi Rui , Qi Xianjun 
Published: March 2022

AbstractIn order to reduce the impact of renewable energy output and load fluctuations and improve the flexibility of the integrated energy system (IES), it is necessary to further promote user participation in integrated demand response (IDR). Therefore, this paper constructs a hierarchical framework that enables the transaction of IDR resources among users by combining the information interaction network established by blockchain and the energy management network established by energy management system. This paper also analyses the comfort of users, the cost of energy purchase by users and the cost of energy use by load aggregators, and then develops a two‐layer optimization model. The results of the simulation show that the model and trading framework constructed in this paper can realize the trading of IDR resources among users, which effectively promotes the participation of users in IDR, reduces the cost of users and load aggregators, reduces the loss of IDR resources, enables more effective integration of dispersed IDR resources and improves the flexibility of IES.
Three new high-mass X-ray binaries in the Large Magellanic Cloud
Authors: Haberl F. , Maitra C. , Vasilopoulos G. , Maggi P. , Udalski A. , Monageng I. M. , Buckley D. A. H. 
Published: March 2022

Context. The Magellanic Clouds host a large population of high-mass X-ray binary (HMXB) systems, and although the Large Magellanic Cloud (LMC) is an order of magnitude more massive than the Small Magellanic Cloud, there are significantly fewer known HMXBs in the former.
Aims. We conducted a search for new HMXBs in XMM-Newton observations that were performed with the aim of investigating supernova remnant candidates in the supergiant shells LMC5 and LMC7. The three observed fields are located in regions that have not been widely explored in the X-ray band.
Methods. We analysed the XMM-Newton data to look for sources with hard X-ray spectrum and their counterparts with optical colours and brightness values that are typical of HMXBs.
Results. We report the discovery of three new Be/X-ray binaries, two of them showing pulsations in their X-ray flux. With a luminosity of 6.5 × 1034 erg s−1, we see that XMMU J045315.1−693242 in LMC7 was relatively X-ray faint. The long-term OGLE I-band light curve of the V = 15.5 mag counterpart suggests a 49.6 day or 24.8 day orbital period for the binary system. Then, XMMU J045736.9−692727, which is also located in LMC7, was brighter, with a luminosity of 5.6 × 1035 erg s−1 and hard spectrum with a power-law photon index of 0.63. The X-ray flux revealed clear pulsations with a period of 317.7 s. We obtained optical high resolution spectra from the V = 14.2 mag counterpart using the SALT-HRS spectrograph. Hα and Hβ were observed in emission with complex line profiles and equivalent widths of −8.0 Å and −1.3 Å, respectively. The I-band light curve obtained from OGLE shows a series of four strong outbursts followed by a sudden drop in brightness by more than 1 mag within 73–165 days and a recovery to the level from before the outbursts. RX J0524.2−6620, previously classified as X-ray binary candidate, is located at the eastern part of LMC5. We report the discovery of 360.7 s pulsations. During the XMM-Newton observation the luminosity was at ∼4 × 1035 erg s−1 and the source showed a hard spectrum with a power-law photon index of 0.78. The Hα emission line profile obtained from SALT-HRS is characterised by two broad peaks with a separation corresponding to ∼178 km s−1, along with an equivalent width of −4.2 Å. The long-term OGLE I-band light curve of the V = 14.9 mag counterpart reveals a quasi-periodic flaring activity while the colour evolution during the flares follows a hysteresis loop with redder colour during the rise. Based on the modelling the Hα line profiles measured from XMMU J045736.9−692727 and RX J0524.2−6620, we derived constraints on the size of the Be disks.
Conclusions. Our discovery of two pulsars among three new Be/X-ray binaries increases the number of known HMXB pulsars in the LMC to 25.
Mehr Sexuelle Bildung wagen!
Authors: Henningsen Anja 
Published: March 2022

ZusammenfassungIn diesem Beitrag wird begründet, warum mit dem Begriff der Sexuellen Bildung einige Begrenzungen überwunden werden können, die in einer ausschließlichen Betrachtung von Sexualerziehung bestehen. Sexuelle Bildung, so wird argumentiert, schafft neue Anschlüsse an die aktuellen Debatten in den Erziehungswissenschaften. Zentrales Anliegen dieses Beitrags ist es, Sexuelle Bildung weiterhin und differenzierter zu diskutieren. Gleichzeitig bedeutet dies keine Abkehr von der Sexualerziehung, sondern vielmehr ihre historischen Wurzeln sowie Intentionen nach wie vor kritisch-reflexiv zu durchleuchten.
Rhodium(I)-Catalyzed Regioselective C–H Alkenylation of 2,2′-Bipyridine Derivatives with Alkynes
Authors: Cheng Guolin , Yu Jia , Wen Si , Tian Qingyu , Chen Yanhui 
Published: March 2022

AbstractIn this work, a Rh(I)-catalyzed C3-alkenylation of 2,2′-bipyri­dine-6-carboxamide with terminal and internal alkynes was developed, providing an efficient access to a broad range of alkenylated 2,2′-bipyridine derivatives with exclusive regioselectivity and stereoselectivity. Deuterium labeling experiments indicate that an irreversible rollover C–H activation process is involved in this reaction.
Microbiology of bile aspirates obtained at ERCP in patients with suspected acute cholangitis
Authors: Gromski Mark A. , Gutta Aditya , Lehman Glen A. , Tong Yan , Fogel Evan L. , Watkins James L. , Easler Jeffrey J. , Bick Benjamin L. , McHenry Lee , Beeler Cole , Relich Ryan F. , Schmitt Bryan H. , Sherman Stuart 
Published: March 2022

Abstract
Background The cornerstone of treatment for acute cholangitis is source control with biliary drainage and early antibiotics. The primary aim of this study was to describe the microbiology of bile aspirate pathogens obtained at the time of endoscopic retrograde cholangiopancreatography (ERCP) in patients suspected of having acute cholangitis.
Methods In this single-center retrospective study, patients were included if a bile aspirate was collected at ERCP for suspicion of acute cholangitis, from 1 January 2010 to 31 December 2016.
Results There were 721 ERCP procedures for suspected acute cholangitis with bile culture results, with 662 positive bile cultures (91.8 %). Pathogens included: Enterococcus species (spp.) 448 (67.7 %); Klebsiella spp. 295 (44.6 %); Escherichia coli 269 (40.6 %); Pseudomonas spp. 52 (7.9 %); and anaerobes 64 (9.7 %). Susceptibility of Klebsiella pneumoniae and E.coli isolates to ciprofloxacin was 88 % and 64 %, respectively. Extended-spectrum beta-lactamases and carbapenem resistance were found in 7.9 % and 3.6 % of Enterobacteriaceae, respectively. There were 437 concurrent blood cultures, of which 174 were positive (39.8 % of cultures drawn). Prior biliary endoscopic sphincterotomy (ES) was evident in 459 ERCP cases (63.7 %), and was associated with increased frequency of Klebsiella spp., Pseudomonas aeruginosa, Enterobacter spp., and Enterococcus spp. Prior biliary ES significantly increased the probability of vancomycin-resistant Enterococcus (VRE).
Conclusions The vast majority of bile cultures (91.8 %) were positive. The susceptibilities of E.coli and K.pneumoniae to ciprofloxacin are lower than historically noted. A notable portion of cultures contained pathogenic drug-resistant organisms. Prior biliary ES is associated with a higher frequency of certain organisms and higher frequency of VRE.