bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circadian clock disruptions link oxidative stress and systemic inflammation to metabolic syndrome in obstructive sleep apnea patients
Authors: Li Xiaoming , Liu Xuejian , Meng Qiu , Wu Xinhao , Bing Xin , Guo Na , Zhao Xuening , Hou Xiaozhi , Wang Baowei , Xia Ming , Li Hui 
Published: August 2022

Objectives: Obstructive sleep apnea (OSA) is an independent risk factor for metabolic syndrome (MetS). Recent studies have indicated that circadian clock genes were dysregulated in OSA. In addition, it is clear that the impairment of circadian clocks drives the progression of MetS. Therefore, we hypothesized that circadian rhythm disruption links OSA with MetS.Methods: A total of 118 participants, who underwent polysomnography (PSG) and were diagnosed as healthy snorers (control, n = 29) or OSA (n = 89) patients based on the apnea–hypopnea index (AHI), were enrolled in the present study. General information, anthropometric data, blood biochemical indicators, clock gene expressions, and levels of oxidative and inflammatory indicators were collected, determined, and compared in all the participants.Results: We found that Brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein 1 (Bmal1) and Differentiated embryo chondrocyte 1 (Dec1) were upregulated, while Period 1 (Per1) was reduced in OSA patients. In addition, these changing trends were closely associated with the hypoxia indicator of AHI and have a significant impact on the presence of MetS components, such as hyperglycemia (Dec1 and Per1, p &lt; 0.05 and 0.001, respectively), hypertension (Bmal1 and Dec1, p &lt; 0.001 and 0.01, respectively), hyperlipidemia (Dec1, p &lt; 0.01), and obesity (Dec1, p &lt; 0.05). Notably, expressions of Dec1 correlated with IR and predicted the presence of MetS in OSA patients. Finally, we also observed that Dec1 expression was interrelated with levels of both oxidative indicators and inflammatory biomarkers (IL-6) in OSA.Conclusion: This study concluded that circadian clock disruptions, especially Dec1, link OSA with MetS in an oxidative and inflammatory-related manner. Circadian clock Dec1 can be used as a specific biomarker (p &lt; 0.001) and therapeutic target in OSA combined with Mets patients.
Exploring the mechanism of action of dapansutrile in the treatment of gouty arthritis based on molecular docking and molecular dynamics
Authors: Cao Jun-Feng , Xingyu Yang  , Li Xiong  , Wu Mei , Chen Shengyan , Xu Hengxiang , Gong Yunli , Zhang Lixin , Zhang Qilan , Zhang Xiao 
Published: August 2022

Purpose: Dapansutrile is an orally active β-sulfonyl nitrile compound that selectively inhibits the NLRP3 inflammasome. Clinical studies have shown that dapansutrile is active in vivo and limits the severity of endotoxin-induced inflammation and joint arthritis. However, there is currently a lack of more in-depth research on the effect of dapansutrile on protein targets such as NLRP3 in gouty arthritis. Therefore, we used molecular docking and molecular dynamics to explore the mechanism of dapansutrile on NLRP3 and other related protein targets.Methods: We use bioinformatics to screen active pharmaceutical ingredients and potential disease targets. The disease-core gene target-drug network was established and molecular docking was used for verification. Molecular dynamics simulations were utilized to verify and analyze the binding stability of small molecule drugs to target proteins. The supercomputer platform was used to measure and analyze the binding free energy, the number of hydrogen bonds, the stability of the protein target at the residue level, the radius of gyration and the solvent accessible surface area.Results: The protein interaction network screened out the core protein targets (such as: NLRP3, TNF, IL1B) of gouty arthritis. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that gouty arthritis mainly played a vital role by the signaling pathways of inflammation and immune response. Molecular docking showed that dapansutrile play a role in treating gouty arthritis by acting on the related protein targets such as NLRP3, IL1B, IL6, etc. Molecular dynamics was used to prove and analyze the binding stability of active ingredients and protein targets, the simulation results found that dapansutrile forms a very stable complex with IL1B.Conclusion: We used bioinformatics analysis and computer simulation system to comprehensively explore the mechanism of dapansutrile acting on NLRP3 and other protein targets in gouty arthritis. This study found that dapansutrile may not only directly inhibit NLRP3 to reduce the inflammatory response and pyroptosis, but also hinder the chemotaxis and activation of inflammatory cells by regulating IL1B, IL6, IL17A, IL18, MMP3, CXCL8, and TNF. Therefore, dapansutrile treats gouty arthritis by attenuating inflammatory response, inflammatory cell chemotaxis and extracellular matrix degradation by acting on multiple targets.
Impact of corporate governance and CEO remuneration on bank capitalization strategies and payout decision in income shocks period
Authors: Xiang Hangqin , Shaikh Erum , Tunio Muhammad Nawaz , Watto Waqas Ahmad , Lyu Yiqing 
Published: August 2022

The purpose of this research is to explore corporate governance and CEO remuneration with banks capitalization strategies and payout policy within the Pakistani banking context. Data were obtained from the financial statements of scheduled banks listed on the Pakistan stock exchange from 2005 to 2020. The findings of the research study revealed that corporate governance mechanisms that promote the bank's shareholders' interests are linked to low capitalization strategies. The size of the board of directors has a significant impact on the capitalization of banks. Banks' capitalization techniques are also adversely correlated with effective board size. The shareholder benefits from low capitalization. Corporate governance is positively related with banking sector instability, as seen by this negative correlation. Bank capitalization strategies have a significant impact on CEO remuneration. In the event of an income shock, dividend payout is essential. Banking sector payout policies are negatively related with corporate governance. In the event of a negative income shock, financial institutions reduce dividends. As a result, it has been argued that effective corporate governance benefits shareholders by reducing capitalization tactics and limiting financial institutions' aggressive payouts.JEL classificationG21, G30, G32, G35.
Emotional dysregulation as trans-nosographic psychopathological dimension in adulthood: A systematic review
Authors: Carmassi Claudia , Conti Lorenzo , Gravina Davide , Nardi Benedetta , Dell'Osso Liliana 
Published: August 2022

IntroductionEmotional dysregulation (ED) is characterized by inappropriate emotional reactions related to environmental or cognitive stimuli. In most recent years, increasing interest has been devoted to its definition and detection across mental disorders for its detrimental role progressively highlighted in both neurodevelopment and adult mental disorders, with implications on the severity of clinical manifestations. The aim of this systematic review was to evaluate and gather the scientific evidence about ED in adult psychiatric population to elucidate the concept of ED as trans-nosographic entity.MethodsThe electronics databases PubMed, Scopus and Web of Science was reviewed to identify studies in accordance with the PRISMA guidelines; at the end of the selection process a total of 29 studies (N = 709; N = 658; N = 1,425) was included. All studies included assessed the presence of ED symptoms, by means of a validate scale in adult (&gt;18 years of age), in clinically diagnosed patients as well as healthy control participants.ResultsOur results suggest ED as a trans-diagnostic factor across multiple mental disorders, such as bipolar disorder, attention deficit hyperactivity disorder, autism spectrum disorder, personality disorders; a better definition of this concept could be helpful to interpret and clarify many clinical cases and improve their diagnostic and therapeutic management.
Pathway linking health information behaviors to mental health condition during the COVID-19 infodemic: A moderated mediation analysis
Authors: Zhang Thomas Hongjie , Tham Jen Sern , Waheed Moniza , Kim Jeong-Nam , Jeong Jae-Seon , Chang Peng Kee , Ahmad Abdul Mua'ti@Zamri 
Published: August 2022

BackgroundThe COVID-19 outbreak is no longer a pure epidemiological concern but a true digital infodemic. Numerous conflicting information and misinformation occupy online platforms and specifically social media. While we have lived in an infodemic environment for more than 2 years, we are more prone to feel overwhelmed by the information and suffer from long-term mental health problems. However, limited research has concentrated on the cause of these threats, particularly in terms of information processing and the context of infodemic.ObjectiveThis study proposed and tested moderated mediation pathways from two types of health information behaviors (social media engagement and interpersonal communication) on information overload and mental health symptoms—long-term stress.MethodsWe conducted a cross-sectional online survey between May and June of 2021 among the Malaysian public. The final sample size was 676 (N = 676). A conceptual model was built to guide the data analysis. We conducted structural equation modeling (SEM), moderation and mediation analyses to examine each direct pathway, moderating and mediating effects.ResultsAccording to the pathway analysis, we found that, during the infodemic period, engaging COVID-19 information on social media positively associated with information overload, but interpersonal communication was negatively related to it. As the proximal outcome, there was also a positive association between information overload and the final outcome, perceived stress. The moderation analysis only reported one significant interaction: risk perception weakened the association between social media engagement and information overload. A conditional indirect effect was demonstrated and the indirect associated between social media engagement and perceived stress mediated through information overload was further moderated by COVID-19 risk perception.ConclusionThis research offers new grounds for understanding health information behaviors and their consequences in the COVID-19 infodemic. We particularly highlighted the distinct functions of health information behaviors in causing information overload, as well as the importance of personal health belief in this process. Our proposed model contributes to the strategies of developing health messaging strategies that may be utilized by public health researchers and health educators in the future.
Effects of gestational low dose perfluorooctanoic acid on maternal and “anxiety-like” behavior in dams
Authors: Merrill Alyssa K. , Conrad Katherine , Marvin Elena , Sobolewski Marissa 
Published: August 2022

Pregnancy is a unique critical window with nearly ubiquitous exposure to low concentrations of endocrine disrupting chemicals, such as per- and poly-fluoroalkyl substances (PFAS). Human and animal research suggests that PFAS compounds disrupt hypothalamic-pituitary-adrenal axis function, with some evidence of altered “anxiety-like” behavior, but little is known about the potential effects on maternal mental health following exposures during pregnancy. Evaluating the consequences of gestational PFAS exposures on maternal health is essential, because approximately 1 in 10 women experience postpartum depression, often with increased anxiety. To address this gap, dams were exposed to a low dose, 0.1 mg/kg, of perfluorooctanoic acid (PFOA) from gestational day 0 to birth. Maternal behavior was then observed from postnatal days 5–9, and “anxiety-like” behavior was measured using open field spontaneous locomotor behavior and elevated plus maze following weaning. No difference was observed in the litter size or sex of offspring. Gestational PFOA exposure altered maternal behavior. Despite similar nursing durations, PFOA dams spent more time nursing in a flat posture and on their side, and less time in kyphosis. Despite significantly quicker first contact, PFOA dams did not return pups to the nest quicker, indicating reduced retrieval latency. At weaning, dams displayed increased “anxiety-like” behaviors in the elevated plus maze with a significantly higher mean duration in the closed arms and reduced choice frequency with significantly lower number of entries in the closed and open arms. PFOA dams showed reductions in ambulatory movement across the session. Pregnancy exposure to PFOA altered both maternal and “anxiety-like” behavior in dams. Additional assays focused on depression-associated behaviors, such as forced swim, anhedonia, and social preference, will further delineate behavioral mechanisms. Further research on the effects of environmental contaminant exposures during pregnancy should investigate how co-exposures to other risk factors, such as stress, may enhance behavioral toxicity. Understanding how environmental contaminant exposure during pregnancy effects maternal depression-associated, and/or “anxiety-like” behavior is necessary for the public health protection of women.
Dampak Covid-19 terhadap Financial Market di Indonesia
Authors: Hadi Prasetyo , Primta Surbakti Lidya , Nurmatias Nurmatias 
Published: August 2022

Covid-19 secara global lebih mengoncangkan ekonomi jika dibandingkan dengan the Great Financial Crisis pada 2007–2008. Hal ini dibuktikan dengan index harga saham gabungan (IHSG) di bursa efek Indonesia mengalami penurunan harga saham yang sangat signifikan.Tujuan penelitian ini adalah untuk mengetahui pengaruh covid-19 terhadap financial market di Indonesia. Menggunakan Pooled data dan STATA 13 digunakan untuk menganalisis data. Sample penelitian ini adalah 44 IHSG harian dengan 9 sektor di Bursa Effek Indonesia untuk masa pembatasan sosial berskala besar (PSBB) dikarenakan Covid-19 ini dimulai 20 Maret 2020 sampai 29 Mei 2020. IHSG untuk semua sektor di BEI yang digunakan untuk mengukur financial market di Indonesia. Penelitian ini menemukan bahwa makin tinggi Covid19 maka semakin tinggi harga saham pada sector agribisnis, sector industry kimia dasar, sector industry lainnya, sector barang konsumsi, sektor sedangkan untuk sector perdagangan tidak ada pengaruhnya. Untuk sector property dan dan sector keuangan semakin tinggi Covid-19 semakin rendah harga saham. Investor mungkin dapat menggunakan temuan ini untuk memahami peran penting dari peningkatan Covid-19 di Indonesia.
Guía de práctica clínica para la prevención primaria y secundaria y diagnóstico temprano de cáncer gástrico
Authors: Oliveros_wilches Ricardo , Grillo-Ardila Carlos Fernando , Vallejo-Ortega María , Gil-Parada Fabio , Cardona-Tobón Mauricio , Páramo-Hernández David , Cuello-Lacouture Eduardo , Rengifo-Pardo Adriana , Bedoya-Urresta Álvaro , Blanco-Avellaneda Camilo , Landazábal-Bernal Gustavo , Vargas-Rubio Rómulo , Pinilla-Morales Raúl , Facundo-Navia Gimar , Calderón-Franco Carlos , Villate-Soto Steffany , García-López Andrea , Torres-Castillo Jenny , Medina-Rojas Yury , Alzate-Granados Juan , Del    Río-Ospina Luisa , Torres-Amaya Ana , Pardo-Turriago Rodrigo 
Published: August 2022

Objetivo: Generar recomendaciones basadas en la evidencia, para la prevención primaria y secundaria, el tratamiento de las lesiones preneoplásicas y el diagnóstico temprano del cáncer gástrico en población adulta, con el propósito de reducir la carga de la enfermedad.
Materiales y métodos: El grupo desarrollador estuvo integrado por profesionales de la salud y tomadores decisiones. Se construyeron preguntas clínicas contestables y se realizó la graduación de los desenlaces. Se elaboró la busqueda de la información en MEDLINE; EMBASE y CENTRAL, siendo actualizada el 18 de octubre de 2018. La pesquisa también abarcó otras fuentes de información como la Revista Colombiana de Gastroenterología y la lectura en “bola de nieve” de las referencias incluidas. Se contactó expertos en la materia con el objeto de identificar estudios relevantes no publicados. Para la construcción de las recomendaciones, se realizó un consenso acorde a los lineamientos propuestos por la metodología GRADE, sopesando a los beneficios, los efectos adversos derivados de la intervención, las preferencias de los pacientes y el potencial impacto de las intervenciones sobre los costos.
Resultados: Se presenta la versión corta de la “Guía de práctica clínica para la prevención primaria, secundaria y diagnóstico temprano de cáncer gástrico” junto su evidencia de soporte y respectivas recomendaciones.
Conclusiones: Como recomendación central para la implementación se recomienda erradicar la infección por H. pylori en los pacientes con o sin factores de riesgo como estrategia de prevención de las condiciones precursoras de cáncer gástrico. La Guía deberá actualizarse en tres años.
Adaptación transcultural de la versión colombiana de la Escala de Soledad de UCLA en pacientes con diagnóstico de cáncer
Authors: Valdelamar Jiménez Adriana , Parra-Alfonso Ana Milena , Sánchez-Pedraza Ricardo , De La Hoz-Restrepo Fernando 
Published: August 2022

Introducción: Considerando que la soledad no deseada es un constructo que ha mostrado un impacto negativo en diferentes aspectos de la salud y que probablemente esté relacionado con resultados negativos en pacientes con cáncer, es importante contar con instrumentos como la escala de soledad de UCLA, versión 03, para evaluar la importancia de este constructo en este tipo de pacientes.
Objetivo: Traducir y adaptar transculturalmente la escala de soledad de UCLA, versión 03 para su uso en pacientes con cáncer en Colombia.
Métodos: El proceso de traducción y adaptación transcultural siguió la metodología propuesta por el grupo EORTC, con el objetivo de lograr la equivalencia semántica con la versión original de la escala. Se realizó una prueba piloto con 20 pacientes colombianos diagnosticados de diferentes tipos de cáncer, que asistieron al Instituto Nacional de Cancerología E.S.E.
Resultados: En la versión conciliada se modificó el ítem UC1. No hubo cambios ni en la traducción de instrucciones, ni en las opciones de respuesta. En la prueba piloto, dos de 20 pacientes informaron que los ítems UC6, UC7, UC11 y UC19 deberían ser modificados y un paciente mencionó que el ítem UC8 era difícil de entender; sin embargo, no se hicieron cambios dado el bajo número de pacientes que reportaron estos hallazgos, y las sugerencias planteadas podían cambiar el sentido y la equivalencia de los ítems con la escala original. Ninguno de los ítems fue ofensivo para los pacientes.
Conclusión: Se generó una versión adaptada transculturalmente para ser validada en pacientes con cáncer en Colombia
Sistem Monitoring dan Smart Farm untuk Ayam Pedaging Berbasis Internet Of Think
Authors: Putra Arik Andrian , Slameto Andika Agus 
Published: August 2022

INTISARI Penelitian menjelaskan sistem monitoring, pemberian pakan otomatis dan pemberian minum otomatis. Sistem ini bekerja dengan mengirimkan informasi kondisi suhu dan kelembapan yang ada didalam kandang ayam pedaging, kemudian sistem juga akan memberikan pakan serta minum otomatis sesuaidengan jadwal yang sudah ditentukan sebelumnya. Secara umum sistem ini terdiri dari Wemos D1 sebagai mikrokontroler, Sensor DHT11 sebagai pendeteksi suhu dan kelembapan pada kandang ayam, Motor servo sebagai motor penggerak katup tandon pakan ayam, dan Submersile Watherpump sebagai pompa pemberian minum. Cara kerja dari sistem ini adalah sensor DHT11 akan mengirimkan data kepada mikrokontroler kemudian akan ditampilkan melalui aplikasi smartphone yaitu Blynk. Kemudian RTC akan mengirimkan data waktu kepada mikrokontroler secara berkala dan jika waktu sudah menunjukkan waktu yang sudah ditentukan maka mikrokotroler akan menghidupan Servo ataupun Watherpump secara otomatis.Kata kunci— IoT, Sensor, Mikrokontroler, Motor Servo, Watherpump. ABSTRACTThis study describes a monitoring system, automatic feeding and automatic drinking. This system works by sending information on the temperature and humidity conditions in the broiler cage, then the system will also provide automatic feed and drink according to a predetermined schedule. In general, this system consists of Wemos D1 as a microcontroller, DHT11 sensor as a temperature and humidity detector in chicken coops, a servo motor as a motor to drive a chicken feed reservoir valve, and a Submersile Watherpump as a drinking pump. The way this system works is where the DHT11 sensor will send data to the microcontroller then it will be displayed through the smartphone application, namely Blynk. Then the RTC will send time data to the microcontroller periodically and if the time has shown the predetermined time, the microcontroller will turn on the Servo or Watherpump automatically..Kata kunci— IoT, Sensor, Mikrokontroler, Motor Servo, Watherpump.
Analisa Penerapan Waterfall Pada Sistem Informasi Penjualan Hoodie “Gakuto” Berbasis Web
Authors: Ong Danny 
Published: August 2022

INTISARIDi era sekarang ini semua kebutuhan sudah bisa didapatkan dengan cara yang mudah dan cepat karena diakibatan oleh teknologi yang dari tahun ketahun makin canggih, contohnya dulu jika kita ingin membeli suatu barang atau pakaian kita harus membeli langsung kepada penjual atau toko – toko yang tersedia. Tapi dengan teknologi yang semakin cangih dan ilmu pengetahuan yang semakin maju sekarang kita tidak perlu lagi atau tidak perlu susah karena sekarang sudah terdapat toko – toko yang menjual barang atau pakaian melalui internet yaitu dengan cara E-Commerce atau yang biasa dikenal dengan toko online. Oleh sebab itu penulis ingin membuat sebuah karya tulis tantang toko online yang bisa menjual pakaian – pakaian dengan mudah dan cepat. Aplikasi ini akan dirancangan dengan menggunakan metode waterfall, dimana sistem ini dibuat dengan cara bertahap mulai dari analisa,desain sistem, pembuatan sistem,implemtasi, sanpai maintance. Agar lebih mudah didalam hal pengerjaannya, dan mengunakan tools PHP dan MySql untuk databasenya, aplikasi ini penulis buat agar manyarakat dapat terbantu dengan adanya aplikasi ini masnyarakat tidak perlu lagi meluangka waktu atau susah - susah datang ketempat langsung untuk membeli sesuatuKata kunci—E-Commerce, PHP, Toko Online, Penjualan ABSTRACTIn this era, all needs can be obtained in a way that is easy and fast because it is caused by technology which is getting more sophisticated from year to year, for example if we want to buy an item or clothing we must buy directly from the seller or the shops that are available. But with increasingly sophisticated technology and increasingly advanced science, we no longer need or need to bother because now there are shops that sell goods or clothing via the internet, namely by e-commerce or commonly known as online stores. Therefore the author wants to make a paper about an online store that can sell clothes - clothes easily and quickly. This application will be designed using the waterfall method, where the system is made in stages starting from analysis, system design, system development, implementation, and maintenance. To make it easier in terms of workmanship, and use PHP and MySql tools for the database, this application is the author for the community to be helped by this application. Kata kunci— E-Commerce, PHP, Online Stores, Sales