bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green intellectual capital and ambidextrous green innovation: The impact on environmental performance
Authors: Asiaei Kaveh , O'Connor Neale G , Barani Omid , Joshi Mahesh 
Published: May 2022

AbstractThis study relies on a unique synthesis of ambidexterity theory and the natural resource orchestration approach to investigate how green intellectual capital elements, namely green human, structural, and relational capital, along with ambidextrous green innovation, trigger a synergy in favor of environmental performance. In particular, this paper primarily aims to test the mediating role of ambidextrous green innovation in the relationship between green intellectual capital and environmental performance. Based on a survey of 105 Iranian public listed companies, the results indicate that green intellectual capital elements are not directly associated with environmental performance. Instead, they influence environmental performance only through the channel of ambidextrous green innovation as a mediating variable. This is the first study to simultaneously embed the resource orchestration theory in the green intellectual capital and ambidexterity literature. The findings of the current study offer new insights into the issue of how organizations gain maximum benefit from the orchestration of their various green assets and capabilities, including green intellectual capital and ambidextrous green innovation.
Crosstalk between IL‐15Rα+tumor‐associated macrophages and breast cancer cells reduces CD8+T cell recruitment
Authors: Zhang Wenlong , Zhang Qing , Yang Nanfei , Shi Qian , Su Huifang , Lin Tingsheng , He Zhonglei , Wang Wenxin , Guo Hongqian , Shen Pingping 
Published: May 2022

AbstractBackgroundInterleukin‐15 (IL‐15) is a promising immunotherapeutic agent owing to its powerful immune‐activating effects. However, the clinical benefits of these treatments are limited. Crosstalk between tumor cells and immune cells plays an important role in immune escape and immunotherapy drug resistance. Herein, this study aimed to obtain in‐depth understanding of crosstalk in the tumor microenvironment for providing potential therapeutic strategies to prevent tumor progression.MethodsT‐cell killing assays and co‐culture models were developed to determine the role of crosstalk between macrophages and tumor cells in breast cancer resistant to IL‐15. Western blotting, histological analysis, CRISPR‐Cas9 knockout, multi‐parameter flow cytometry, and tumor cell‐macrophage co‐injection mouse models were developed to examine the mechanism by which IL‐15Rα+tumor‐associated macrophages (TAMs) regulate breast cancer cell resistance to IL‐15.ResultsWe found that macrophages contributed to the resistance of tumor cells to IL‐15, and tumor cells induced macrophages to express high levels of the α subunit of the IL‐15 receptor (IL‐15Rα). Further investigation showed that IL‐15Rα+TAMs reduced the protein levels of chemokine CX3C chemokine ligand 1 (CX3CL1) in tumor cells to inhibit the recruitment of CD8+T cells by releasing the IL‐15/IL‐15Rα complex (IL‐15Rc). Administration of an IL‐15Rc blocking peptide markedly suppressed breast tumor growth and overcame the resistance of cancer cells to anti‐ programmed cell death protein 1 (PD‐1) antibody immunotherapy. Interestingly, Granulocyte‐macrophage colony‐stimulating factor (GMCSF) induced γ chain (γc) expression to promote tumor cell‐macrophage crosstalk, which facilitated tumor resistance to IL‐15. Additionally, we observed that the non‐transcriptional regulatory function of hypoxia inducible factor‐1alpha (HIF‐1α) was essential for IL‐15Rc to regulate CX3CL1 expression in tumor cells.ConclusionsThe IL‐15Rc‐HIF‐1α‐CX3CL1 signaling pathway serves as a crosstalk between macrophages and tumor cells in the tumor microenvironment of breast cancer. Targeting this pathway may provide a potential therapeutic strategy for enhancing the efficacy of cancer immunotherapy.
“It's something I'll do until I die”: A qualitative examination into why older women in the U.S. continue screening mammography
Authors: Brotzman Laura E. , Shelton Rachel C. , Austin Jessica D. , Rodriguez Carmen B. , Agovino Mariangela , Moise Nathalie , Tehranifar Parisa 
Published: May 2022

AbstractBackgroundProfessional guidelines in the U.S. do not recommend routine screening mammography for women ≥75 years with limited life expectancy and/or poor health. Yet, routine mammography remains widely used in older women. We examined older women's experiences, beliefs, and opinions about screening mammography in relation to aging and health.MethodsWe performed thematic analysis of transcribed semi‐structured interviews with 19 women who had a recent screening visit at a mammography clinic in New York City (average age: 75 years, 63% Hispanic, 53% ≤high school education).ResultsThree main themes emerged: (1) older women typically perceive mammograms as a positive, beneficial, and routine component of care; (2) participation in routine mammography is reinforced by factors at interpersonal, provider, and healthcare system levels; and (3) older women do not endorse discontinuation of screening mammography due to advancing age or poor health, but some may be receptive to reducing screening frequency. Only a few older women reported having discussed mammography cessation or the potential harms of screening with their providers. A few women reported they would insist on receiving mammography even without a provider recommendation.ConclusionsOlder women's positive experiences and views, as well as multilevel and frequently automated cues toward mammography are important drivers of routine screening in older women. These findings suggest a need for synergistic patient, provider, and system level strategies to reduce mammography overuse in older women.
Using buckwheat starch to produce slowly digestible biscuits with good palatability
Authors: Yu Shiyao , Prakash Alok , Pora Bernard L. R. , Hasjim Jovin 
Published: May 2022

AbstractBackground and ObjectiveDue to the rapid digestibility, cooked starch can cause a high postprandial blood glucose response (hyperglycemia), one of the risk factors for metabolic diseases, such as obesity and diabetes. The objective was to understand the properties of starch that provided slow digestibility in low‐moisture baked goods. Buckwheat (Fagopyrum esculentum Moench) starch was used to prepare biscuits with slowly digestible starch and was compared with wheat (Triticum aestivum) starch.FindingsBuckwheat starch had higher gelatinization temperature and smaller breakdown viscosity (in pasting curve) than wheat starch. Slower starch digestion rate and higher amount of undigested starch were observed when 60% (w/w) wheat flour in biscuits was substituted by buckwheat starch than by wheat starch. The biscuits containing buckwheat starch or wheat starch also showed a structure with lower firmness than the control biscuits.ConclusionBuckwheat starch was more resistant to gelatinization and breakage during baking, and thus was less susceptible to enzyme digestion in biscuits than wheat starch.Significance and NoveltyThis is the first study utilizing a starch having a normal amylose content without any modification, except partial gelatinization during baking, as a source of slowly digestible starch in biscuits. Buckwheat starch not only provided slow digestibility, but also improved the palatability of the biscuits, creating a smoother and less firm texture than those made using whole grain flour.
Chemistry of wheat gluten proteins: Qualitative composition
Authors: Wieser Herbert , Koehler Peter , Scherf Katharina A. 
Published: May 2022

AbstractBackground and ObjectivesWheat gluten proteins make up one of the most complex protein aggregates in nature. Their qualitative and quantitative composition is determined by genetic and environmental factors as well as technological processes.FindingsGluten proteins comprise ω5‐, ω1,2‐, α‐, and γ‐gliadins as well as high‐molecular‐weight glutenin subunits (HMW‐GS) and low‐molecular‐weight (LMW) GS. About 50% of gluten proteins are monomeric gliadins with MWs from 28,000 to 55,000, while about 15% are present as disulfide‐linked oligomeric proteins with MWs between 70,000 and 700,000, called HMW‐gliadins. The remaining 35% are disulfide‐linked polymeric glutenins with MWs from 700,000 to more than 10 million. Intrachain disulfide bonds, present in all types except ω‐gliadins, stabilize the three‐dimensional structure, while interchain disulfide bonds, mainly linking HMW‐GS and LMW‐GS, generate oligomers and polymers.ConclusionsIn this review, we provide an updated and detailed insight into the chemistry of wheat gluten proteins with a focus on the qualitative composition.Significance and NoveltyAn enhanced understanding of gluten protein structure and how it is affected will be essential to select and breed more resilient wheat varieties with favorable processing properties to help ensure nutrition and food security worldwide.
Targeted Metabolomics Using LC‐MS in Neurospora crassa
Authors: Carrillo Alexander J. , Halilovic Lida , Hur Manhoi , Kirkwood Jay S. , Borkovich Katherine A. 
Published: May 2022

AbstractThe filamentous fungus Neurospora crassa has historically been a model for understanding the relationship between genes and metabolism—auxotrophic mutants of N. crassa were used by Beadle and Tatum to develop the one‐gene‐one‐enzyme hypothesis for which they earned the Nobel Prize in 1958. In the ensuing decades, several techniques have been developed for the systematic analysis of metabolites in N. crassa and other fungi. Untargeted and targeted approaches have been used, with a focus on secondary metabolites over primary metabolism. Here, we describe a pipeline for sample preparation, metabolite extraction, Liquid Chromatography‐Mass Spectrometry (LC‐MS), and data analysis that can be used for targeted metabolomics of primary metabolites in N. crassa. Liquid cultures are grown with shaking in a defined minimal medium and then collected using filtration. Samples are lyophilized for 2 days at –80°C, pulverized, and mixed with a solution to extract polar metabolites. The metabolites are separated and identified using LC‐MS, with downstream analysis using Skyline interpretive software. Relative levels of hundreds of metabolites can be detected and compared across strains. © 2022 Wiley Periodicals LLC.Basic Protocol: Metabolite extraction and detection from Neurospora crassa cell cultures using Liquid Chromatography‐Mass Spectrometry
Cardiorenal syndrome and the association with fitness: Data from a telerehabilitation randomized clinical trial
Authors: Langlo Knut Asbjørn Rise , Lundgren Kari Margrethe , Zanaboni Paolo , Mo Rune , Ellingsen Øyvind , Hallan Stein Ivar , Aksetøy Inger‐Lise Aamot , Dalen Håvard 
Published: May 2022

AbstractAimsTo investigate the associations of cardiorespiratory fitness with cardiac, vascular, renal and cardiorenal characteristics in chronic heart failure in a telerehabilitation randomized clinical trial. Secondly, to evaluate the associations of cardiorenal syndrome with the effects of exercise.Methods and resultsSixty‐nine heart failure patients attended baseline examination, and 61 patients were randomly assigned 1:1 to 3‐month telerehabilitation or control. Data were collected at baseline and 3‐month post‐intervention, including echocardiography and vascular ultrasound, laboratory tests, exercise test with peak oxygen consumption (VO2peak) measurement and 6‐min walk test (6MWT). Baseline VO2peak and 6MWT distance was 0.85 mL*min−1*kg−1 lower and 20 m shorter per 10 mL/min/1.73m2 lower estimated glomerular filtration rate (both P < 0.001). Heart failure patients with cardiorenal syndrome had 3.5 (1.1) mL*min−1*kg−1 lower VO2peak and diastolic dysfunction grade 2–3, and elevated filling pressure was >50% more common compared with those without (all P < 0.05). At the 3‐month post‐intervention follow‐up, only the non‐CRS patients in the intervention group increased VO2peak (0.73 (0.51) mL*min−1*kg−1), whereas VO2peak in the CRS subpopulation of controls decreased (−1.34 (0.43) mL*min−1*kg−1). Cardiorenal syndrome was associated with a decrease in VO2peak in CRS patients compared with non‐CRS patients, −0.91 (0.31) vs. 0.39 (0.35) mL*min−1*kg−1 respectively, P = 0.013.ConclusionsCardiorenal syndrome was negatively associated with VO2peak and 6MWT distance in chronic HF, and the associations were stronger than for heart failure phenotypes and other characteristics. The effect of exercise was negatively associated with cardiorenal syndrome. Exercise seems to be as important in heart failure patients with cardiorenal syndrome, and future studies should include CRS patients to reveal the most beneficial type of exercise.
Designing of high‐performance dye‐sensitized solar cells by using a new electrolyte based on deep eutectic solvents
Authors: Ahmadi Raheleh , Heydari Dokoohaki Maryam , Tashkhourian Javad , Zolghadr Amin R. , Safavi Afsaneh 
Published: May 2022

SummaryThe present research is aimed to develop an efficient electrolyte based on deep eutectic solvents (DESs) for dye‐sensitized solar cells (DSSCs). In this regard, the performance of the propylene carbonate (PC) and tetrabutylammonium iodide (TBAI) based DES (PC/TBAI‐DES) as a new electrolyte solvent for DSSCs is evaluated for the first time. Herein, the effects of various electrolyte components, namely the amount of acetonitrile (AN), iodine, and 1‐ethyl‐3‐methylimidazolium iodide (EmimI), are investigated. The optimal conditions are achieved with an electrolyte composition of 0.1 M of iodine and EmimI in a binary mixture of PC/TBAI‐DES and AN (volume ratio 80:20). The DSSCs based on this electrolyte attained a significant conversion efficiency of 10.04% (Jsc = 21.94 mA cm2, Voc = 0.78 V, and FF = 0.58) under 1 sun (AM 1.5) illumination. Moreover, a detailed view of the molecular arrangement of PC/TBAI‐DES solution near the titanium dioxide and platinum solid surfaces as electrodes of DSSCs is investigated using molecular dynamics simulations. Besides, the interaction parameters between TBAI ion pair and PC molecule are determined through density functional theory.
The prognostic impact of preoperative body composition in perihilar and intrahepatic cholangiocarcinoma
Authors: Lurje Isabella , Czigany Zoltan , Eischet Sarah , Bednarsch Jan , Ulmer Tom Florian , Isfort Peter , Strnad Pavel , Trautwein Christian , Tacke Frank , Neumann Ulf Peter , Lurje Georg 
Published: May 2022

Abstract
Cholangiocarcinoma (CCA) is a rare but highly aggressive malignancy of the biliary system. Although it is amenable to surgical resection in early disease, outcomes are frequently dismal. Here, we investigated the prevalence of body composition (BC) alterations and their prognostic role for surgical patients with intrahepatic (iCCA) and perihilar (pCCA) disease. Patients undergoing curative‐intent surgery for iCCA or pCCA between 2010 and 2019 at University Hospital Aachen were included. Axial computed tomography images were retrospectively assessed with a segmentation tool (3D Slicer) at the level of the third lumbar vertebra to determine lumbar skeletal muscle (SM) index, mean SM radiation attenuation, and visceral fat area. The related BC pathologies sarcopenia, myosteatosis, visceral obesity, and sarcopenic obesity were determined using previously described cutoffs. A total of 189 patients (86 with iCCA, 103 with pCCA) were included. Alterations of BC were highly prevalent in iCCA and pCCA, respectively: sarcopenia, 33% (28/86) and 39% (40/103); myosteatosis, 66% (57/86) and 66% (68/103); visceral obesity, 56% (48/86) and 67% (69/103); sarcopenic obesity, 11% (9/86) and 17% (17/103). Sarcopenia and myosteatosis did not have a significant prognostic role for disease‐free survival (DFS) and overall survival (OS). Patients with iCCA with sarcopenic obesity (n = 9) had significantly shorter OS than patients without sarcopenic obesity (n = 7; log‐rank p = 0.002; median OS, 11 months and 31 months; 1‐year mortality, 55.6% [5/9] and 22% [17/77]; 5‐year mortality, 88.9% [8/9] and 61% [47/77], respectively). In multivariable analysis, only tumor‐related risk factors remained prognostic for DFS and OS. Sarcopenic obesity may affect clinical outcomes after curative‐intent surgery for iCCA, indicating that imaging‐based analysis of BC may hold prognostic value for long‐term survival and could aid preoperative patient selection.
Calibration and validation of three evapotranspiration models in a tea field in the humid region of south‐east China
Authors: Zhang Chuan , Li Lanlan , Yan Haofang , Ou Mingxiong , Akhlaq Muhammad , Zhang Wencheng , Huang Song 
Published: May 2022

AbstractEvapotranspiration (ETc) is the most important part of agricultural water consumption. Accurate determination of the ETc of tea trees is important in the water management of tea fields. In this study, three models, the Penman–Monteith (PM), Priestley–Taylor (PT) and crop coefficient (KC) models, were applied and calibrated using meteorological data of 2017 in a tea field. The calibrated models were validated using the Bowen ratio energy balance (BREB) method with the data of 2018 and 2019 in the tea field. The canopy resistance of the PM model was calibrated by the inverse method with the BREB‐measured ETc using the Katerji and Perrier (KP) submodel with R2 equal to 0.80. The annual mean value of the coefficient in the PT model (α = 1.03) was determined based on the BREB results and meteorological data. In addition, the crop coefficients of tea trees based on the measured ETc and reference evapotranspiration (ET0) were comprehensively evaluated, with values of 0.86, 1.19 and 0.96 at the three growth stages, showing a cyclical evolution within a year. The PT model performed best, with a root mean square error (RMSE) equal to 0.82 mm day−1 and a Nash–Sutcliffe efficiency (NSE) equal to 0.90. The PM model underestimated ETc with RMSE equal to 0.79 mm day−1 and NSE equal to 0.84, while the KC method overestimated ETc.
A primer on Post‐COVID‐19 conditions and implications for clinical pharmacists
Authors: Cluck David , Covert Kelly L. , Wagner Jamie L. , Chastain Daniel B. 
Published: May 2022

AbstractCoronavirus disease 2019 (COVID‐19) is caused by severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) and is largely viewed as an acute illness involving multiple organ systems. In the wake of the acute illness, many survivors fully recover and return to baseline, while others suffer from a wide range of lingering symptoms collectively known as “post‐COVID conditions”. The recognition of these conditions as a clinical entity represents the first step in developing a targeted plan for recovery and symptom mitigation. While interventions to directly minimize or reduce new, recurrent, or persistent symptoms are currently unknown, pharmacists can play a key role in optimizing management of these patients.
Pharmacist‐led inhaler training for nurses on an acute care pulmonary unit
Authors: Johnson Blake R. , Franks Andrea S. , Bullock Laura N. , Dennis Danielle L. , Heidel R. Eric , Self Timothy H. 
Published: May 2022

AbstractIntroductionAppropriate inhaler technique is important for optimizing treatment of pulmonary conditions, including asthma and chronic obstructive pulmonary disease. Nurses often administer inhaled medications in the acute care setting, providing an opportunity to educate patients on appropriate inhaler technique. To date, no published study has evaluated the impact of pharmacist‐led training on skill improvement and retention among acute care pulmonary nursing staff regarding their ability to instruct a patient on inhaler technique.ObjectiveThe primary objective of this study was to evaluate both the immediate and sustained impact of pharmacist‐led inhaler technique for acute care pulmonary nurses using hands‐on training for instructing on appropriate inhaler use.MethodsThis prospective study used a one group pre‐test, posttest design for an educational intervention. Pharmacists conducted a brief in‐service followed by an individualized simulation where the nurse participant instructed a standardized patient on how to use a placebo metered dose inhaler (MDI) and dry powder inhaler (DPI) before and after receiving individual technique training by a pharmacist. Participant inhaler counseling technique was assessed via standardized checklist. Nurses then received individual coaching from a pharmacist regarding proper inhaler technique. After the pharmacist intervention, the nurse again counseled the standardized patient on how to use the devices. Measures included investigator rating on inhaler technique at baseline, after training, and 2 months later.ResultsAfter the interventions, participant performance significantly improved for MDI and DPI technique. At the 2‐month follow‐up, there was a statistically significant increase for MDI and DPI technique from baseline.ConclusionBrief, pharmacist‐led inhaler technique education results in sustained improvements in inhaler administration skills among pulmonary nursing staff.
Worldwide characteristics and trends of pharmacist interventions contributed to minimize health disparities
Authors: Ozaki Aya F. , Cadiz Christine L. , Hurley‐Kim Keri , Wisseh Cheryl , Knox Erin D. , Lee Joyce Y. , Wang Ashley , Patel Sakhi G. , Chan Alexandre 
Published: May 2022

AbstractHealth disparities in outcomes are ubiquitous and must be addressed. Pharmacist‐led clinical services have been shown to improve patient outcomes and reduce costs. However, their involvement in addressing health disparities has not been well documented. We conducted a literature review to summarize worldwide pharmacist‐involved interventions that contributed to reducing health disparities. The overarching goal is to provide guidance on future directions to advance health equity. PubMed, Scopus, Embase, and CINAHL were searched from inception to October 2021. Studies included were those that evaluated pharmacist‐involved interventions contributing to the mitigation of health disparities. Pilot or preliminary studies and those published in non‐English languages were excluded. Study characteristics, clinical areas, targeted patient population, types of interventions, and outcomes were evaluated. A total of 151 studies were included, of which 27% were randomized controlled trials. The majority of studies (82%) conducted in high‐income countries targeted cardiometabolic conditions (49%). Infectious diseases were commonly managed conditions among studies (56%) conducted in low‐/middle‐income countries. Most pharmacist‐involved interventions were delivered to rural communities (45%), followed by patients with low income (33%) and racial/ethnic minorities (24%). A minimal number of studies (1%) addressed gender‐ or disability‐related interventions. Multidisciplinary team care (70%) and medication management (64%) were the most prevalent care models reported among the studies, followed by education (49%) and screenings/health fairs (21%). Commonly reported outcome measures included laboratory values (38%), medication utilization (29%), and medication adherence (16%). Only 7% and 9% of the studies reported humanistic and economic outcomes, respectively. Pharmacists have been involved in a variety of clinical interventions targeting a diverse range of patient populations, which unveiled pharmacists' roles in contributing to reducing health disparities. Variability of implemented interventions exists geographically and in certain groups for whom few interventions have been implemented, highlighting the need for further efforts to achieve equity in health care.