bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of a Tele‐Ultrasound Robot During COVID‐19 Pandemic
Authors: Jiang Wenli , Zhao Xia , Gan Tian , Liu Ying , Luo Shuilian , Zhu Meifang , Chen Sikai , Jiang Yu , Wu Meng 
Published: June 2022

ObjectiveTo investigate the accuracy of ultrasonic diagnosis using the tele‐ultrasound robot in Leishen Shan Hospital.MethodTwenty‐two patients with novel coronavirus pneumonia from Leishen Shan Hospital voluntarily participated in this study. Their thyroids, neck vessels, hepatobiliaries and kidneys were scanned by both a tele‐ultrasound robot manufactured by Imabot Co., Ltd, Wuhan and conventional method. The ultrasound diagnosis of each patient was compared, and the ultrasound images obtained by the two methods were mixed together and double‐blindly diagnosed by an experienced ultrasound radiologist.ResultsThere were 44 positive lesions in 110 sites of 22 patients. Of which the two methods, 40 positive lesions were detected by the robotic method with 4 lesions missed (2 small polyps of gallbladder, 1 small hemangioma of liver and 1 small cyst of kidney) and 1 lesion misdiagnosed (normal carotid artery was misdiagnosed as carotid atherosclerotic plaque); 44 positive lesions were detected by conventional method with 1 small cyst of the liver was missed. There was no statistically significant difference in the accuracy rate between the robotic method and the conventional method using the chi‐square test of the four‐grid data (P>.05).ConclusionThe application of tele‐ultrasound robot meets the standard of patient care during the pandemic. The method is feasible to provide adequate ultrasound information to diagnose common abdominal, vascular, superficial organ pathologies in patients with COVID‐19 with acceptable accuracy compared with a conventional ultrasound scan.
Kinetics study of the OH + SiH4 hydrogen abstraction reaction: A theoretical analysis
Authors: Espinosa‐Garcia Joaquín 
Published: June 2022

AbstractThe temperature dependence of the rate constants and the kinetics isotope effects of the OH + SiH4 hydrogen abstraction reaction were theoretically studied. Three different kinetics approaches were used in this study: variational transition state theory with multidimensional tunneling (VTST/MT) corrections, quasi‐classical trajectory (QCT) calculations, and ring polymer molecular dynamics (RPMD). These studies were performed on a global analytical potential energy surface based on explicitly correlated high level ab initio calculations developed in the present work. While the experimental rate constants are practically independent with temperature, the VTST/MT results show a pronounced dependence, the QCT partially corrects this behavior, and RPMD rates are in better agreement with experiment. In this case, in the experimental common temperature range, 300–600 K, the T‐expression for the RPMD rate constants is: k(T) = 6.40 × 10−13.T0.52exp(−0.10/T). The kinetics isotope effects, H/D, are small in this temperature range, revealing the small importance of tunneling effects in this very exothermic and low barrier reaction. Different factors, such as anharmonicity, the zero‐point violation problem or limitations of the surface, without ruling out experimental uncertainties, were analyzed to explain the discrepancies.
Folded circulator with shorted Y‐junction for high power applications
Authors: Guo Song , Song Kaijun , Li Qian , Zhou Yidi 
Published: June 2022

AbstractIn this letter, a compact suspended‐stripline circulator with high power‐handling capability has been proposed. The presented double‐knotted circulator is constructed by folding the structure through an air‐filled micro‐coaxial line. Power‐handling capability is increased using a single‐sided ferrite disc and dielectric loading at the central junction. Moreover, another Y‐junction shorted to the ground is coupled on the other side of the substrate to improve the circuit impedance matching. The equivalent circuit model and high power characteristics of the suspended‐stripline circulator are proposed and analyzed. An X‐band double‐knotted circulator has been designed, simulated, fabricated, and measured. The measured results show a reasonable agreement with the simulated ones.
A highly linearized second harmonic injected GaN power amplifier
Authors: Abbasnezhad F. , Tayarani M. , Abrishamifar A. , Nayyeri V. 
Published: June 2022

AbstractThis article presents an active second harmonic injection technique for linearizing power amplifiers (PAs). In this method, a second harmonic signal with adjustable amplitude and phase, which is generated by a differential pair network, is injected into the input of a PA in a forward path. The tunable input and output matching circuits of the proposed second harmonic generator provide linearization capability in a wide frequency band. To validate the concept, the proposed second harmonic injection technique was implemented to linearize a GaN PA working around 1.5 GHz. It was shown that applying the proposed linearization method increases the output 1‐dB compression point from 33.5 dBm to 39.5 dBm (about 2 dB lower than saturation power) under the CW signal. Furthermore, the backed‐off efficiency at a higher adjacent channel power ratio was improved, and improvement of 16 dB at 200 MHz frequency bandwidth was achieved for an 8 MS/s 64‐quadratic‐amplitude modulation signal.
Propagation of sine beam in uniaxial crystal orthogonal to optical axis
Authors: Bayraktar Mert 
Published: June 2022

AbstractThis study analyzes propagation properties of sine beam in uniaxial crystal orthogonal to optical axis. Huygens‐Fresnel integral is solved to find the received field. Influence of source beam parameters, crystal refractive index settings, and propagation distance is analyzed in detail. Our results yield that intensity concentrates on minimum and maximum of x‐axis at middle and longer propagation distances. Although, sinusoidal waveform is conserved at close distance. We hope that these results will be used in optical tracking applications.
Consensus‐based recommendations on communication and education regarding primary care physical therapy for patients with systemic sclerosis
Authors: Liem Sophie I. E. , Vliet Vlieland Theodora P. M. , van de Ende Cornelia H. , Dittmar Sonja , Schriemer Marisca R. , Bodegom‐Vos Leti van , Peter Wilfred F. H. , Vries‐Bouwstra Jeska K. de 
Published: June 2022

AbstractObjectiveThis study aimed to develop recommendations for communication and postgraduate education regarding primary care physical therapy for systemic sclerosis (SSc) patients.MethodsA virtual Nominal Group Technique was used with tasks forces for communication (n = 18) and education (n = 21). Both included rheumatologists, physical therapists (PTs) in primary, secondary or tertiary care, rheumatology nurses, advanced nurse practictioners and patient representatives. Three online meetings were organised for each task force to discuss (1) current bottlenecks; (2) potential solutions; and (3) the resulting draft recommendations. After the final adjustments, participants rated their level of agreement with each recommendation on a scale from 0 (not at all agree) to 100 (totally agree), using an online questionnaire.Results19 and 34 recommendations were formulated for communication and education, respectively. For communication the main recommendations concerned the provision of an overview of primary care physical therapists with expertise in rheumatic and musculoskeletal diseases to patients and rheumatologists, the inclusion of the indication by the rheumatologist in the referral to the physical therapist and low‐threshold communication with the rheumatologist in case of questions or concerns of the physical therapist. For postgraduate education three types of “on demand” educational offerings were recommended with varying levels of content and duration, to match the competencies and preferences of individual primary care physical therapists.ConclusionUsing a systematic qualitative approach, two multi‐stakeholder task forces developed practical recommendations for primary care physical therapists' communication with hospital‐based care providers and postgraduate education regarding the treatment of SSc patients.
Sustainability Estimates of Coastline Fish Hatcheries in Saudi Arabia
Authors: Young Benjamin C. , Shaikhi Ali AL 
Published: June 2022

Abstract
This study examined Red Sea and Arabian Gulf coastline fish hatcheries of the leading aquaculture companies in Saudi Arabia for future sustainability strategies. Evaluations were performed on seven marine fish hatchery facilities in 2021. The factors estimated were production capacity, existing infrastructure, main cultured fish species, source of broodstock and seed stock, and range of water temperature and salinity. Six of seven coastline marine fish hatcheries lacked broodstock capacity. The water supply to all hatcheries is adequate from the Red Sea and Arabian Gulf coastline. In five hatcheries, discharge limitations will serve as constraints in their expansion and development. A live food production section was absent in five hatcheries. Most of the cultured species in hatcheries were Asian Seabass Lates calcarifer, Gilthead Bream Sparus aurata, Sabaki Tilapia Oreochromis spilurus, and Sobaity Seabream Sparidentex hasta. Only two hatcheries produced fry, with an average monthly fry production of 500,000–1,000,000 individuals. The source of seed stock in five hatcheries depended on imports or other hatcheries. Sustainability strategies should focus on increasing broodstock capacity, live food production, and new culture species.
Spatial Variability in the Fish Assemblage of a Large River–Reservoir Ecosystem
Authors: Smith Nathan G. , Buckmeier David L. , Fleming B. Paul , Grubh Archis R. , Homer Michael D. , Robertson Sarah M. 
Published: June 2022

Abstract
Physical and hydrologic connectivity among river–reservoir ecosystem (RRE) segments, including the river, river–reservoir interface (RRI), and reservoir, requires consideration of management at larger spatial scales. Multiple objectives (e.g., ecosystem function, sport fisheries, and maximizing fish diversity) seem well suited to this broad spatial scale; however, data limitations regarding the distribution of taxa within RREs currently hamper such an approach. We quantified the fish assemblage of the Trinity River–Lake Livingston ecosystem in Texas, USA, using a stratified approach to determine the contribution of individual segments to the overall fish assemblage. In general, fish assemblages varied along a continuum from the river to the reservoir; however, fish assemblages in several river backwaters did not follow this gradient, thus adding diversity to the overall RRE. Variability in fish assemblages among ecosystem segments was the result of both species composition and relative abundance. Species richness (N = 58 total) was highest in the river segment (N = 49) followed by the RRI (N = 46) and was much lower in the reservoir (N = 36). In contrast, average catch per standardized unit of sampling effort (all species combined) was greatest in the RRI, about 25% lower in the reservoir, and about 50% lower in the river. Across the ecosystem, 26 species (45%) were considered common, while 32 species (55%) were considered rare. Notably, species of conservation need were not always most abundant in river habitats, and species supporting recreational fisheries were not always most dominant in the reservoir. These findings suggest that the RRE can serve as an appropriate spatial scale for both conservation and recreational fishery management actions.
Effects of a web‐based relapse prevention program on abstinence: Secondary subgroup analysis of a pilot randomized controlled trial
Authors: Takano Ayumi , Miyamoto Yuki , Shinozaki Tomohiro , Matsumoto Toshihiko , Kawakami Norito 
Published: June 2022

AbstractAimThe effect of a web‐based relapse prevention program might vary depending on a specific population if the study participants included drug users with various characteristics. This secondary analysis explored subgroups among Japanese drug users that may benefit from a web‐based relapse prevention program.MethodsOutpatients with drug use disorder (n = 48) were randomly assigned to an 8‐week, six‐session web‐based relapse prevention program (intervention group) or web‐based self‐monitoring only (control group). We tested the effects of the intervention on abstinence in different subgroups divided by a primary abused drug (methamphetamine vs other drugs), previous face‐to‐face relapse prevention (received vs not received), and outpatient treatment term (long‐term: ≥3 years vs short‐term: <3 years). Consecutive abstinence duration from the primary abused drug was compared in the subgroups, and the interaction between the intervention condition and the subgroup condition was assessed.ResultsIn the subgroup with short‐term outpatient treatment, the intervention group maintained better abstinence than the control group. For those who used methamphetamine or those who had previously received a face‐to‐face relapse prevention program, the intervention group showed larger effect sizes than the results from all the participants. However, the interaction between the intervention condition and the subgroup condition was not significant for any subgroup.ConclusionsThis study suggests that patients with short‐term treatment may benefit from a web‐based relapse prevention program as an alternative treatment. We need to recruit and allocate patients considering their treatment term in a future definitive trial.
Synthesis, antimicrobial and anticancer activities of Tetronic 1107 Schiff bases
Authors: Alasmary Fatmah Ali , Kenawy El‐Refaie , El‐Deeb Nehal M. , Kamoun Elbadawy A. , Khattab Samar A. , Karami Abdulnasser Mahmoud , Cinelli Patrizia , Azaam Mohamed M. 
Published: June 2022

AbstractAs a result of the serious issues connected to the bacterial infections, there is an imperious need to improve strong and ecofriendly antimicrobial polymers to overcome the limitations of conventional antimicrobial agents. In this trend, poloxamines (Tetronics) which are X‐shaped poly(ethylene oxide)–poly(propylene oxide) diblocks linked to a focal ethylenediamine group; were successfully modified to produce Tetronic Schiff base for enhancing the biological activities of Tetronic 1107. Modification of tetronic 1107 (T1107) was proceeded throughout chloroacetylation of T1107 followed by amination using p‐phenylenediamine then the latter was treated with different aldehydes to yield Tetronic Schiff bases. Characterization of Tetronic Schiff bases was carried out by 1H‐NMR, Fourier‐transform infrared spectroscopy, X‐ray diffraction, elemental analysis and thermogravimetric analysis (TGA) analyses. The antimicrobial activities of four tested compounds coded (EK1, EK2, EK3, and EK4) were quantified using Microtiter‐assay methods. The obtained data revealed potential antimicrobial activities for tested compounds against all tested microbes with priority against Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus. Sample coded EK4 exhibited the most effective treatment against P. aeruginosa, Candida albicans, S. aureus and E. Coli with minimal inhibitory concentration values of 6, 16, 12.5, and 1.5 μM, respectively. Furthermore, the safety results confirmed that EK4 and EK1 were the safest treatment with IC50 values of 76.01 and 62.67 μM, respectively. In addition, all tested compounds showed significant anticancer effects against MDA‐MB‐231cell line, while EK3 was effective treatment against A549 cell line with IC50 values of 39.63 μM. Meanwhile, both EK2 and EK4 showed the highest selectivity index (SI) values against MDA‐MB‐231 cell line with values 2.5 and 3.07, respectively. Interestingly, EK4 showed the maximum SI values on A549 and Hep‐G2 cell lines with values 1.62 and 1.52, respectively.
Ileus in patients treated with immune checkpoint inhibitors: A retrospective, pharmacovigilance study using Food and Drug Administration Adverse Event Reporting System database
Authors: Gao Siyuan , He Zhichao , Zhu Jianhong , Liang Dan , Zhao Wenxia , Yang Shan , Jiang Wei , Qiu Kaifeng , Yu Xiaoxia , Wu Junyan 
Published: June 2022

AbstractObjectiveImmune checkpoint inhibitors (ICIs) have been widely used in cancer treatment; however, some case reports suggested that ICIs treatment might result in ileus. This study aims to comprehensively reveal the relationship between ileus and ICIs treatment in real‐world cases from Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS).MethodsReports from January 1, 2011 to December 31, 2020 were extracted from the FAERS. ICIs‐related adverse events in patients were defined as related to use of anti‐programmed cell death protein 1 antibodies (PD‐1, nivolumab and pembrolizumab), anti‐programmed cell death‐ligand 1 inhibitors (PD‐L1, atezolizumab, durvalumab, avelumab, and cemiplimab), and anti‐cytotoxic T‐lymphocyte‐associated protein 4 (CTLA‐4, ipilimumab and tremelimumab). ICIs‐related ileus cases were identified to characterize their clinical features. Reporting odds ratios (ROR) and information component (IC) were used to assess the relationship between ICIs and ileus.ResultsAmong the 105 001 cases related to ICIs, 245 were reported with ICI‐related ileus. The affected patients were mainly elderly (median age, 64.5 years) and male (58%, n = 143). The median onset for all cases was 36 (range 0–880) days, and no statistical difference was observed between monotherapy and combination therapy (PD‐1 or PD‐L1 plus CTLA‐4) (p = 0.21). Most patients required drug withdrawal treatment (n = 113, 74%) and can achieve a recovered‐resolved state (n = 72, 46%). All ICIs were significantly associated with ileus (ROR = 4.27, 95%Cl: 3.75–4.85; IC = 2.04, 95%Cl: 1.79–2.31). Ileus events were most commonly reported in PD‐1 treatment (n = 164, ROR = 3.83, 95%Cl: 3.28–4.48; IC = 1.90, 95%Cl: 1.62–2.21).ConclusionThis pharmacovigilance database analysis suggested that ICIs are related to ileus. However, combination therapy may not speed up the onset of ileus.
Temperature dependence of deformation behavior in amorphous poly(butylene terephthalate)/poly(carbonate) blends
Authors: Zhang Wenyang , Shi Jiangao , Jiang Shichun 
Published: June 2022

AbstractMechanical properties of amorphous poly(butylene terephthalate)/poly(carbonate) (PBT/PC) blends were studied at various temperatures. Two distinct regions associated with the mechanical response at various temperatures were identified. Also the temperature‐related microstructural evolution of amorphous PBT/PC blends was explored at 30°C and 50°C by synchrotron radiation WAXS. The mesophase of PBT could be obtained from the melt by rapid quenching. The presence of PC suppresses the mesophase formation during rapid quenching and also suppresses PBT crystallization during deformation. Structure models were proposed to describe the deformation process of amorphous PBT/PC blends at 30°C and 50°C.
Poor tolerability of cystic fibrosis transmembrane conductance regulator modulator therapy in lung transplant recipients
Authors: Doligalski Christina Teeter , McKinzie Cameron J. , Yang Anita , Lobo L. Jason , Coakley Raymond 
Published: June 2022

AbstractElexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) is a highly effective therapy for patients with cystic fibrosis (CF) with potential benefits in lung transplant recipients (LTRs) for extrapulmonary CF manifestations; however, tolerability and efficacy in this population are largely unknown. We report our experience with ELX/TEZ/IVA in LTRs for extrapulmonary complications of CF including tolerability, drug–drug interactions, and therapeutic benefit. All LTRs at a single center initiated on ELX/TEZ/IVA were reviewed. Adverse events and patient‐reported outcomes attributed to ELX/TEZ/IVA were documented. Pulmonary function, tacrolimus requirements in mg/kg/dl, body mass index (BMI), and reason for initiation were assessed at the initiation of ELX/TEZ/IVA, and at 12 months post‐initiation or at the time of discontinuation for those in whom therapy was discontinued. Thirteen LTRs were initiated on ELX/TEZ/IVA at a mean of 115 ± 92 months post‐transplant. All were initiated on ELX/TEZ/IVA for sinus or sinus and gastrointestinal CF manifestations. Five (38.4%) patients discontinued therapy due to declining pulmonary function (2/5, 40%), mood disturbances (2/5, 40%), or lack of benefit (1/5, 20%). Of the eight patients who remain on ELX/TEZ/IVA, four reported adverse effects and three LTRs temporarily held therapy. Six (46.2%) LTRs reported improvement in sinus symptoms, while four (30.7%) reported improved gastrointestinal symptoms. Weight declined in the cohort overall. Tacrolimus dose requirements decreased following initiation of ELX/TEZ/IVA therapy, with a 50% decline in dose requirements observed. In our experience, ELX/TEZ/IVA in LTRs is poorly tolerated with modest perceived extrapulmonary benefit and a significant effect on tacrolimus dose requirements. More data are needed to determine the benefits of ELX/TEZ/IVA therapy in LTRs.
Knowledge about foot‐specific foot falls risk factors and exercise among physiotherapists in the UK and Portugal: A cross‐sectional survey
Authors: Conde Monserrat , Hendry Gordon J. , Woodburn Jim , Skelton Dawn A. 
Published: June 2022

AbstractBackground and purposeFoot‐related falls risk factors and specific foot and ankle exercise interventions are within the scope of Physiotherapy, yet little is known about United Kingdom (UK) and Portugal‐based (PT) physiotherapists' self‐perceived knowledge, confidence and practice of such interventions, or perceptions of patients' falls prevention knowledge. The purpose of this study was to assess levels of self‐reported knowledge, confidence, and practices surrounding foot‐specific falls risk and exercise for fall prevention in physiotherapists working in the UK and in Portugal. It also aimed to explore physiotherapists' views about their participants' falls prevention knowledge.MethodsA self‐report online survey was developed, and pilot tested in both nations. Registered Physiotherapists were invited to participate through their professional associations, social media and snowballing. Mann‐Whitney tests were used to compare mean ranks of ordinal variables between nations and Chi‐square test to assess the independency between pairs of variables. Spearman's correlation coefficient (rs) was used to measure the association between pairs of variables (p < 0.05).Results682 physiotherapists participated in the survey [UK n = 229 (mean (SD) age = 43(10) years, 86.9% female]; PT n = 453 (mean (SD) age = 33(9) years, 78.3% female]. Among physiotherapists with a caseload of ≥70% older adults, more PT‐based physiotherapists held postgraduate qualifications (p = 0.01). Most physiotherapists correctly identified generic and foot‐specific risk factors (≥70% of participants for each item). More UK‐based physiotherapists reported always prescribing ankle and foot exercises (42.6% vs. 33%, p =< 0.001) and displayed higher levels of self‐reported confidence surrounding exercise‐based interventions.DiscussionOur sample of UK and Portugal‐based physiotherapists are aware of the contribution of foot‐specific risk factors and exercise to falls prevention, with the former group being more confident in exercise‐based interventions. Both groups of physiotherapists perceived that their older patients had little knowledge about these topics, with UK older adults having slightly better knowledge on generic falls risk factors at first contact. Future studies and strategies for knowledge translation and education in foot health and foot function screening and management for physiotherapists, within a falls prevention scope, may be informed by this study.