bluuebunny/crossref_metadata_2025_split huggingface dataset:
A scoping review of freight rail noise and vibration impacts on domestic animal health and welfare
Authors: Trigg J , Naweed A , Kinnear S 
Published: January 2022

AbstractMultiple benefits of freight rail activity have been shown for commercial agribusiness, yet the effects of freight rail-related noise and vibration on domestic livestock health and welfare has so far received little research attention. This scoping review examines peer-reviewed and grey literature addressing associations between freight rail noise, vibration and impacts on domestic livestock. Six databases (Scopus, Science Direct, SAGE, TRID, SPARK, ARRB) were searched for relevant literature published from 1980–2019.PRISMAsearch procedures were used to identify 28 publications relevant to domestic livestock, as well as noise or vibration impact of rail applicable to the freight rail context. Included publications addressed a range of livestock and related species, covering descriptive, review, and experimental findings on noise and vibration impacts. Five publications addressed vibration effects, and 23 addressed noise effects. Effects of noise and vibration on different species indicated that adverse effects vary depending on exposure intensity. The literature indicates that specific thresholds for noise and vibration exposure should be considered when managing freight rail impacts on commercial agribusiness involving avian and mammalian species. Freight rail noise and vibration likely exceeds thresholds for discomfort and harm for avian and mammalian species. Future research should consider case studies that specifically focus on integrating freight rail noise and vibration data to derive species-specific guides for animal health and welfare purposes.
Cortisol is not enough: A complex stress reaction in tethered goats
Authors: Hydbring-Sandberg E , von Walter L Winblad , Forkman B 
Published: January 2022

AbstractThe purpose of this study was to assess the diversity of physiological stress responses elicited by tethering versus loose holding in the Swedish domestic goat (Capra hircus). Eight goats were randomly divided into two groups and the experiment was performed in a crossover design. Six goats had implanted transmitters that registered heart rate and arterial blood pressure telemetrically and blood samples were taken on separate days. Heart rate increased around feeding both when the goats were held loose in pairs, and when they were tied up. When the goats were tethered, the heart rates and blood pressures were higher, and the concentrations of ß-endorphin and oxytocin lower, compared to when held loose in pairs. In conclusion, housing and the company of another animal affect arterial blood pressure, heart rate, and the concentrations of ß-endorphin and oxytocin in goats, but the cortisol and vasopressin concentrations did not differ between the treatments. The higher arterial blood pressure and heart rate, and lower concentrations of ß-endorphin and oxytocin in tethered goats indicate that being tied up may be more stressful for the goats compared to being held loose. The use of single measures, eg cortisol concentrations, was not sufficient to give an accurate picture of the animals’ response to the management system. This study demonstrates the importance of using a wide variety of physiological measures when evaluating stress in animal welfare research.
Is working memory training efficient? Effects on IQ and school performance in Brazilian children
Authors: Barbosa‐Pereira Drielle , Martins Pedro S. R. , Ferreira‐Junior Luiz Alves , da Costa Marina Freitas Alves , Paixão Janaína Paula Chaves , Costa Renato Ramalho , Saldanha‐Silva Renata , Mansur‐Alves Marcela 
Published: January 2022

AbstractWorking memory training (WMT) for children has received great attention in recent scientific investigations. However, evidence on program efficacy is still sparse. This study aimed to investigate the effect of a WMT software program (Programa de Ativação da Memória de Trabalho [PRAMEMT]) in promoting gains on cognitive and school related abilities. To investigate its effect, 78 school children attending 1st to 5th grades (52.6% girls; mean age = 7.87 years; SD = 1.44) were randomly allocated to a control (n = 37) or an experimental (n = 41) group. The children participated in five intervention sessions. The control group answered questions related to the same animals and themes featured in the PRAMEMT, but unrelated to working memory. The results suggested that there were gains in the performance intelligence quotient (p < .05; d = −0.54) and phonological awareness (p < .05; d = −0.52) in the experimental group; however, there was no change in overall cognitive performance. Possible mechanisms for these findings are discussed.
Derivation and Validation of Algorithms to Identify Patients With Immunoglobulin‐G4‐Related Disease Using Administrative Claims Data
Authors: Wallace Zachary S. , Fu Xiaoqing , Cook Claire , Perugino Cory A. , Zhang Yuqing , Stone John H. , Choi Hyon K. 
Published: January 2022

ObjectiveImmunoglobulin‐G4‐related disease (IgG4‐RD) is a systemic autoimmune disease that can affect nearly any organ, but its epidemiology remains poorly understood. Validated algorithms to identify cases in claims data will enable studies to describe IgG4‐RD epidemiology in the general population.MethodsPotential claims‐based algorithms were developed by IgG4‐RD experts using a combination of International Classification of Diseases, Ninth Revision (ICD‐9) and International Classification of Diseases, 10th Revision (ICD‐10) codes, dispensed medications, and procedure codes for immunoglobulin G (IgG) subclass testing. Algorithms were tested using Medicare Parts A, B, and D linked to medical records (2007‐2017). Classification of cases as IgG4‐RD was determined using the American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) classification criteria for IgG4‐RD. We estimated the positive predictive value (PPV) of each algorithm; sensitivity was determined using a cohort of patients with IgG4‐RD also enrolled in Medicare Parts A, B, and D during the study period.ResultsWe identified seven algorithms that used a combination of ICD‐9 and ICD‐10 codes, medication prescriptions, and/or IgG subclass tests to identify patients with IgG4‐RD. The PPV of algorithms in the derivation cohort ranged from 57% to 100%, and sensitivity ranged from 0% to 58%. The best performing algorithm in the validation cohort had a PPV of 81% and a sensitivity of 58%. Typical IgG4‐RD manifestations were observed in the cohort (n = 36) assembled by this algorithm, including 50% with sialadenitis, 64% with pancreatic disease, 31% with renal disease, and 59% with an elevated IgG4 concentration.ConclusionWe derived and validated a well‐performing algorithm to identify IgG4‐RD cases with typical manifestations of the disease. The claims‐based algorithm can be used in research studies of IgG4‐RD.
Recent Progress on N‐heterocyclic Carbene Catalysts in Chemical Fixation of CO2
Authors: Chen Peibo , Xiong Tingkai , Pan Yingming , Liang Ying 
Published: January 2022

AbstractN‐heterocyclic carbene and related complexes are a class of catalysts with excellent catalytic activity which are widely used in the chemical fixation of carbon dioxide. This review focuses on the application of a carbene‐metal catalytic system, carbene‐free‐metal catalytic system and synergistic catalytic technology of various technologies in the conversion of carbon dioxide. The possible role of carbene materials in chemical carbon fixation is discussed by analyzing several types of typical chemical carbon fixation mechanisms.
The ontogeny of knuckle‐walking and dorsal metacarpal ridge prominence in chimpanzees
Authors: Sarringhaus Lauren , Mitani John C. , MacLatchy Laura M. 
Published: January 2022

AbstractObjectivesThis study examines the sensitivity of the development of the dorsal metacarpal ridge (DMR) to the frequency of knuckle‐walking during ontogeny in chimpanzees, and compares the prevalence and prominence of the DMR in hominoids and baboons.Materials and MethodsWe characterized the type and frequency of quadrupedalism of wild chimpanzees of different ages from the Ngogo community, Uganda. Using museum specimens, we quantified third metacarpal DMR angle and height in Pan individuals of different developmental stages, and in adult Gorilla, Pongo, Hylobates, and Papio.ResultsWhen terrestrial, all quadrupedalism consisted of knuckle‐walking, although older individuals knuckle‐walked more than younger. The total amount of quadrupedalism engaged in by different age groups while arboreal was consistent; however, knuckle usage while arboreally quadrupedal increased with age. The DMR ridge did not emerge in Pan until older infancy, after the onset of knuckle‐walking, and reached prominence by the juvenile stage. The DMR angle increased significantly after juvenility but relative height did not. Adult Pan and Gorilla have more prevalent and prominent DMRs than Papio; the DMR was rare in Pongo and absent in Hylobates.DiscussionThe timing of development of the DMR in chimpanzees supports it as a knuckle walking character, as does its occurrence in gorillas, and virtual absence in suspensory orangutans and gibbons. The DMR in baboons differs in appearance and frequency from DMRs in African apes, and so differentiates knuckle‐walking from digitigrady in catarrhines. The relationship between the DMR and loading of a vertical hand while terrestrial deserves further study.
Plasma‐Induced Nanocrystalline Domain Engineering and Surface Passivation in Mesoporous Chalcogenide Semiconductor Thin Films
Authors: Ashok Aditya , Vasanth Arya , Nagaura Tomota , Eguchi Miharu , Motta Nunzio , Phan Hoang‐Phuong , Nguyen Nam‐Trung , Shapter Joseph G. , Na Jongbeom , Yamauchi Yusuke 
Published: January 2022

AbstractThe synthesis of highly crystalline mesoporous materials is key to realizing high‐performance chemical and biological sensors and optoelectronics. However, minimizing surface oxidation and enhancing the domain size without affecting the porous nanoarchitecture are daunting challenges. Herein, we report a hybrid technique that combines bottom‐up electrochemical growth with top‐down plasma treatment to produce mesoporous semiconductors with large crystalline domain sizes and excellent surface passivation. By passivating unsaturated bonds without incorporating any chemical or physical layers, these films show better stability and enhancement in the optoelectronic properties of mesoporous copper telluride (CuTe) with different pore diameters. These results provide exciting opportunities for the development of long‐term, stable, and high‐performance mesoporous semiconductor materials for future technologies.
Intercalation‐Activated Layered MoO3 Nanobelts as Biodegradable Nanozymes for Tumor‐Specific Photo‐Enhanced Catalytic Therapy
Authors: Zhou Zhan , Wang Yanlong , Peng Feng , Meng Fanqi , Zha Jiajia , Ma Lu , Du Yonghua , Peng Na , Ma Lufang , Zhang Qinghua , Gu Lin , Yin Wenyan , Gu Zhanjun , Tan Chaoliang 
Published: January 2022

AbstractThe existence of natural van der Waals gaps in layered materials allows them to be easily intercalated with varying guest species, offering an appealing strategy to optimize their physicochemical properties and application performance. Herein, we report the activation of layered MoO3 nanobelts via aqueous intercalation as an efficient biodegradable nanozyme for tumor‐specific photo‐enhanced catalytic therapy. The long MoO3 nanobelts are grinded and then intercalated with Na+ and H2O to obtain the short Na+/H2O co‐intercalated MoO3−x (NH−MoO3−x) nanobelts. In contrast to the inert MoO3 nanobelts, the NH−MoO3−x nanobelts exhibit excellent enzyme‐mimicking catalytic activity for generation of reactive oxygen species, which can be further enhanced by the photothermal effect under a 1064 nm laser irradiation. Thus, after bovine serum albumin modification, the NH−MoO3−x nanobelts can efficiently kill cancer cells in vitro and eliminate tumors in vivo facilitating with 1064 nm laser irradiation.
Dissection of Light‐Induced Charge Accumulation at a Highly Active Iron Porphyrin: Insights in the Photocatalytic CO2 Reduction
Authors: Pugliese Eva , Gotico Philipp , Wehrung Iris , Boitrel Bernard , Quaranta Annamaria , Ha‐Thi Minh‐Huong , Pino Thomas , Sircoglou Marie , Leibl Winfried , Halime Zakaria , Aukauloo Ally 
Published: January 2022

AbstractIron porphyrins are among the best molecular catalysts for the electrocatalytic CO2 reduction reaction. Powering these catalysts with the help of photosensitizers comes along with a couple of unsolved challenges that need to be addressed with much vigor. We have designed an iron porphyrin catalyst decorated with urea functions (UrFe) acting as a multipoint hydrogen bonding scaffold towards the CO2 substrate. We found a spectacular photocatalytic activity reaching unreported TONs and TOFs as high as 7270 and 3720 h−1, respectively. While the Fe0 redox state has been widely accepted as the catalytically active species, we show here that the FeI species is already involved in the CO2 activation, which represents the rate‐determining step in the photocatalytic cycle. The urea functions help to dock the CO2 upon photocatalysis. DFT calculations bring support to our experimental findings that constitute a new paradigm in the catalytic reduction of CO2.
Advance modification of polyacrylonitrile nanofibers for enhanced removal of hexavalent chromium from water
Authors: Sharafoddinzadeh Donya , Salehi Maryam , Jansone‐Popova Santa , Herath Amali , Bhattacharjee Linkon 
Published: January 2022

AbstractHexavalent chromium [Cr(VI)] is a known carcinogenic and mutagenic heavy metal. Its level in drinking water is regulated worldwide to protect public health. This study presents a novel chemical method to modify the polyacrylonitrile (PAN) nanofibers for efficient Cr(VI) removal from water. The PAN nanofibers with an average diameter of 165 nm are produced using the electrospinning technique. Through a 2‐step chemical modification process, the amidine polyacrylonitrile (APAN) nanofibers are synthesized by the conversion of nitrile groups [CN] in PAN nanofibers into amidines [C(N═NH)(NH2)]. The attenuated total reflectance Fourier transform (ATR‐FTIR) spectroscopy revealed the successful conversion of nitrile groups into amidoximes, resulting in amidoximated polyacrylonitrile nanofibers, and subsequent conversion into amidine functional groups, forming the APAN nanofibers. Greater concentration of hydroxylamine hydrochloride, increased reaction time and temperature yielded higher conversion of nitrile groups into amidoximes to a maximum of 37%. The Cr(VI) uptake by APAN nanofibers was found as a multilayer adsorption process modeled by Freundlich isotherm. The maximum Langmuir Cr(VI) adsorption capacity for APAN nanofibers was found as 225 mg g−1 at pH = 3.0 after 4.0 h exposure duration. The regeneration study revealed the excellent reusability of APAN nanofibers after five adsorption/desorption cycles.
Antibodies to Cartilage Oligomeric Matrix Protein Are Pathogenic in Mice and May Be Clinically Relevant in Rheumatoid Arthritis
Authors: Ge Changrong , Tong Dongmei , Lönnblom Erik , Liang Bibo , Cai Weiwei , Fahlquist‐Hagert Cecilia , Li Taotao , Kastbom Alf , Gjertsson Inger , Dobritzsch Doreen , Holmdahl Rikard 
Published: January 2022

ObjectiveCartilage oligomeric matrix protein (COMP) is an autoantigen in rheumatoid arthritis (RA) and experimental models of arthritis. This study was undertaken to investigate the structure, function, and relevance of anti‐COMP antibodies.MethodsWe investigated the pathogenicity of monoclonal anti‐COMP antibodies in mice using passive transfer experiments, and we explored the interaction of anti‐COMP antibodies with cartilage using immunohistochemical staining. The interaction of the monoclonal antibody 15A11 in complex with its specific COMP epitope P6 was determined by x‐ray crystallography. An enzyme‐linked immunosorbent assay and a surface plasma resonance technique were used to study the modulation of calcium ion binding to 15A11. The clinical relevance and value of serum IgG specific to the COMP P6 epitope and its citrullinated variants were evaluated in a large Swedish cohort of RA patients.ResultsThe murine monoclonal anti‐COMP antibody 15A11 induced arthritis in naive mice. The crystal structure of the 15A11–P6 complex explained how the antibody could bind to COMP, which can be modulated by calcium ions. Moreover, serum IgG specific to the COMP P6 peptide and its citrullinated variants was detectable at significantly higher levels in RA patients compared to healthy controls and correlated with a higher disease activity score.ConclusionOur findings provide the structural basis for binding a pathogenic anti‐COMP antibody to cartilage. The recognized epitope can be citrullinated, and levels of antibodies to this epitope are elevated in RA patients and correlate with higher disease activity, implicating a pathogenic role of anti‐COMP antibodies in a subset of RA patients.
Heteroscedasticity test of high‐frequency data with jumps and market microstructure noise
Authors: Liu Qiang , Liu Zhi , Zhang Chuanhai 
Published: January 2022

AbstractIn this paper, we are interested in testing whether the volatility process is constant or not during a given time span by using high‐frequency data with the presence of jumps and market microstructure noise. Based on estimators of integrated volatility and spot volatility, we propose a nonparametric procedure to depict the discrepancy between local variation and global variation. We show that our proposed test statistic converges to a standard normal distribution if the volatility is constant, and diverges to infinity otherwise. Simulation studies verify the theoretical results and show a good finite sample performance of the test procedure. We also apply our test procedure to some real high‐frequency financial datasets. We observe that in almost half of the days tested, the assumption of constant volatility within a day is violated. And this is due to that the stock prices in the periods near the opening and closing are highly volatile and account for a relatively large proportion of intraday variation.
Attention to live eye contact in adolescents with autism spectrum disorder
Authors: Kikuchi Yukiko , Akechi Hironori , Senju Atsushi , Tojo Yoshikuni , Osanai Hiroo , Saito Atsuko , Hasegawa Toshikazu 
Published: January 2022

AbstractA number of studies have reported diminished attention to the eyes in individuals with autism spectrum disorder (ASD). These studies predominantly used static images of faces as stimuli. Recent studies, however, have shown enhanced response to eye contact in typically developing (TD) individuals when they observe a person in a live interaction. We investigated physiological orienting to perceived eye contact in adolescents with ASD and TD adolescents when they observed a person in live interaction or viewed a photograph of the same person's face. We measured heart rate (HR) deceleration as an index of attentional orienting. Adolescents with ASD, as well as TD adolescents, showed significant HR deceleration for the direct gaze compared to an averted gaze in the live condition, but not in the photographic condition. The results suggest an intact response to perceived eye contact in individuals with ASD during a live face‐to‐face interaction.Lay SummaryIndividuals with autism spectrum disorder (ASD) have a different eye gaze pattern when observing photographic faces. However, little is known about how individuals with ASD process a real person's face. We measured heart rate (HR) and found that adolescents with ASD showed the typical decline in HR when they made eye contact with a real person, which suggests that both groups of individuals directed their attention to eye contact in a live face‐to‐face interaction.
Capabilities for circularity: Overcoming challenges to turn waste into a resource
Authors: Wade Belinda , Meath Cristyn , Griffiths Andrew 
Published: January 2022

AbstractAlthough designing out waste is a core principle of the circular economy, in established companies, waste may not easily be designed out requiring innovation to develop alternative, value creating, uses for the waste material. This article presents a longitudinal, empirical study of the SME Rock Trade Industries, a company focused on sustainability in the quarrying sector, seeking to achieve zero waste of their extracted resource. Capabilities enabling the creation of products from the company's waste are examined through qualitative analysis, within established categories of sensing, seizing and reconfiguration. Our research highlights the importance of capabilities in innovation, experimentation, research and development, and stakeholder connections in reconceptualising waste as a resource. Presenting a model of the capability development over time, we proposed the strength of the desire to create change combined with the deviation of the desired change from the marketplace determine the set of dynamic capabilities required.
Atomic force spectroscopy‐based essay to evaluate oocyte postovulatory aging
Authors: Battistella Alice , Andolfi Laura , Zanetti Michele , Dal Zilio Simone , Stebel Marco , Ricci Giuseppe , Lazzarino Marco 
Published: January 2022

AbstractPostovulatory aging is a process occurring in the mature (MII) oocyte leading the unfertilized ones to apoptosis. The optimal time window of fertility for different mammalian species after oocytes maturation depends on its timeliness: the higher the time elapsed from the accomplishment of the MII stage, the lower are the chances of fertilization and of development of a viable embryo. In the in vitro fertilization, the selection of competent oocytes for intracytoplasmic sperm injection (ICSI) is mostly made by the visual inspection of the MII oocyte morphology, which does not allow to determine the oocyte postovulatory age. On the other hand, more specific tests usually involve some kind of staining, thus compromising the viability of the oocyte for reproductive purposes. Hence, the need of a noninvasive analysis of oocyte aging to improve the success rate of in vitro fertilization procedures. Here, we exploit atomic force microscopy to examine the evolution of the mechanical properties of mouse oocytes during in vitro postovulatory aging. Three hours before the occurrence of any visual morphological feature related to degradation, we observe a sudden change of the mechanical parameters: the elastic modulus doubles its initial value, while the viscosity decreases significantly. These mechanical variations are temporally correlated with the release of the cortical granules, investigated by fluorescence microscopy. Interestingly, the oocyte mechanics correlates as well with the yield of embryo formation, evaluated up to the blastocyst formation stage. These results demonstrate that minimally invasive mechanical measurements are very sensitive to the aging of the oocyte and can be used as a label‐free method to detect the age of the postovulatory oocytes.
Photo‐Cross‐Linking between BrU and Pyrene Residues in an RNA/DNA Hybrid
Authors: Tashiro Ryu , Yum Ji Hye , Park Soyoung , Sugiyama Hiroshi 
Published: January 2022

AbstractIn this study, we investigated the photoreaction of BrU in a pyrene‐labeled DNA duplex, RNA duplex, and DNA/RNA hybrids. We found that the photoreactivity of BrU changed dramatically from hydrogen abstraction to cross‐linking by changing the conformation of the duplex from the B‐form to the A‐form. Among three A‐form structures, the largest amount of cross‐linked products was observed when BrU was incorporated into the RNA strand and the pyrene was conjugated to the 5′ end of the DNA. These results indicate that the contact manner of pyrene was different between A‐ and B‐form duplexes. This is a rare example of the use of the reactivity of bromouracil to analyze the contact between a small molecule with a weak binding affinity and a nucleic acid.