bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of LHRH analogs on lower urinary tract symptoms associated with advanced prostate cancer in real clinical practice: ANALUTS study
Authors: Morote Juan , Gómez‐Caamaño Antonio , de Celis Raúl Poza , Gómez‐Veiga Francisco , Ciria Juan P. , Calleja Jesús , Extramiana Javier , Pérez‐Sampietro Maria , Perrot Valerie , Angulo Javier C. ,   ANALUTS Study Group
Published: September 2022

AbstractAimsTo estimate the prevalence of lower urinary tract symptoms (LUTS) in patients with prostate cancer scheduled to receive LHRH analogs, and to assess the effectiveness of LHRH analogs on LUTS in patients presenting moderate/severe symptoms.MethodsProspective, noninterventional, multicenter study conducted at 28 centers in Spain and Portugal. LUTS were evaluated using the International Prostate Symptom Score (IPSS) at baseline, 24 and 48 weeks after initiation of treatment. Subanalyses were performed according to age and concomitant treatment (radiotherapy, alpha‐blockers, and antiandrogens).ResultsA total of 354 patients were treated with LHRH analogs for 48 weeks. The percentage of patients with moderate/severe LUTS (IPSS > 7) decreased from 60.2% (n = 213/354) at baseline to 52.8% (n = 187/354) at Week 48. Among patients with moderate/severe LUTS at baseline: 73.7% (n = 157/213) still had moderate/severe LUTS at Week 48; percentage reductions of patients with LUTS at Week 48 were statistically significant (p < 0.05) overall and by age or concomitant treatment, except for alpha‐blockers (84.2% patients receiving them still had moderate/severe LUTS at Week 48). All IPSS items, including quality of life for urinary symptoms, improved throughout the study. The only predictor of response to treatment with LHRH analogs that improved IPSS by 3 points after 48 weeks was baseline testosterone levels. Lower baseline testosterone levels were associated with greater improvement in IPSS after treatment with LHRH analogs (odds ratio 0.998, 95% confidence interval 0.996–1.000, p = 0.0277).ConclusionLHRH analogs have a positive effect in patients with locally advanced or metastatic prostate cancer presenting moderate/severe LUTS regardless of age or concomitant treatment received (radiotherapy, antiandrogens, or alpha‐blockers).
How we approach localized vascular anomalies
Authors: Pahl Kristy S. , Pabon‐Ramos Waleska M. , Jeng Michael R. 
Published: September 2022

AbstractVascular anomalies are a group of disorders divided into two distinct subtypes: vascular tumors and vascular malformations. Vascular tumors are proliferative in nature, while malformations are nonproliferative. Simple, localized vascular malformations refer to a group of malformations that are localized to a single area of involvement. These simple malformations include capillary, lymphatic, venous, and arteriovenous malformations. The pediatric hematologists and oncologists are becoming increasingly involved in the diagnosis and management of these disorders. This review presents four cases as a means to discuss the diagnosis, clinical and imaging features, and management strategies of simple, localized vascular malformations.
How we approach coagulopathy with vascular anomalies
Authors: Mack Joana M. , Crary Shelley E. 
Published: September 2022

AbstractSome vascular anomalies can present with challenging hematologic aberrations. Kaposiform hemangioendothelioma (KHE) may be complicated with Kasabach–Merritt phenomenon (KMP) and stagnant blood flow in slow‐flow malformations can promote activation and consumption of coagulation factors, which results in bleeding and clotting known as localized intravascular coagulopathy (LIC). These patients can experience significant morbidity secondary to pain due to thrombosis and are at higher risk of hematologic complications during surgical procedures. No standard of care has been established to prevent or manage these complications. This review focuses on the management of coagulopathy in children and adults with vascular anomalies.
Imaging of pediatric extremity soft tissue tumors: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper
Authors: Acord Michael Richard , Pace Erika , El‐Ali Alexander , Chaturvedi Apeksha , Iyer Ramesh S , Navarro Oscar M , Pandit‐Taskar Neeta , K Parikh Ashishkumar , Schechter Ann , Shaikh Raja , McCarville M Beth 
Published: September 2022

AbstractPediatric soft tissue tumors of the extremity include rhabdomyosarcoma and nonrhabdomyosarcoma neoplasms. This manuscript provides consensus‐based imaging recommendations for imaging evaluation at diagnosis, during treatment, and following completion of therapy for patients with a soft tissue tumor of the extremity.
An investigation to enhance the mechanical property of high‐performance thermoplastic composite through different plasma treatment
Authors: Kantharaju Sudheendra , Vinodhini Jennifer , M Govindaraju , Bhowmik Shantanu 
Published: September 2022

AbstractIn this study, polyetherketone was investigated as the high‐performance thermoplastic resin for fabrication of carbon fiber reinforced polymer composite. The composites were manufactured by film‐fiber stacking process and consolidation by compression molding. The surfaces are modified with different plasma treatment (argon, nitrogen, and air) to overcome the inert nature of carbon fiber surface and subsequent changes were analyzed through atomic force microscopy, X‐ray photoelectron spectroscopy, and contact angle measurements. The effectivity of each type of plasma treatment in improvement of the surface—roughness, composition, and wettability were quantified and the subsequent effect on the mechanical properties was demonstrated by measurement of tensile properties and interlaminar shear strength (ILSS). The changes in interfacial morphology of the composite post plasma treatment have been characterized by scanning electron microscopy. From the test results, nitrogen plasma was found to most effective with a 43% increase in mean tensile strength and 25% increase in ILSS when compared to untreated composite.
The isothiocyanate sulforaphane induces respiratory burst oxidase homologue D‐dependent reactive oxygen species production and regulates expression of stress response genes
Authors: Arruebarrena Di Palma Andrés , Perk Enzo A. , Carboni Martín E. , García‐Mata Carlos , Budak Hikmet , Tör Mahmut , Laxalt Ana M. 
Published: September 2022

AbstractSulforaphane (SFN) is an isothiocyanate‐type phytomolecule present in crucifers, which is mainly synthesized in response to biotic stress. In animals, SFN incorporated in the diet has anticancer properties among others. The mechanism of action and signaling are well described in animals; however, little is known in plants. The goal in the present study is to elucidate components of the SFN signaling pathway, particularly the production of reactive oxygen species (ROS), and its effect on the transcriptome. Our results showed that in Arabidopsis, SFN causes ROS production exclusively through the action of the NADPH oxidase RBOH isoform D that requires calcium as a signaling component for the ROS production. To add to this, we also analyzed the effect of SFN on the transcriptome by RNAseq. We observed the highest expression increase for heat shock proteins (HSP) genes and also for genes associated with the response to oxidative stress. The upregulation of several genes linked to the biotic stress response confirms the interplay between SFN and this stress. In addition, SFN increases the levels of transcripts related to the response to abiotic stress, as well as phytohormones. Taken together, these results indicate that SFN induces an oxidative burst leading to signaling events. This oxidative burst may cause the increase of the expression of genes such as heat shock proteins to restore cellular homeostasis and genes that codify possible components of the signaling pathway and putative effectors.
Unraveling origin of chemoselectivity and regioselectivity of iridium‐catalyzed B(4)–H functionalization of o‐carborane by alkyne
Authors: Chen Zitong , Liu Jiying , Liu Jiabin , Bao Panpan , He Hailing , Xia Hui , Zhang Wenjing 
Published: September 2022

AbstractFunctionalization at target site is an extremely challenging subject for surface modification of o‐carborane. It is a common tactic to introduce a directing group onto the C(2)–H vertex to induce exclusive B(4,5)–H functionalizations. In this study, was investigated. The computational results indicate that the formal [4 + 2] annulation going via the reductive elimination mechanism has kinetic priority than alkenylation via the decarboxylation mechanism. This is in excellent agreement with the experimental results of carborano‐isocoumarin as the major product. Given the alkyne insertion product, the protonation of alkene is likely to occur before decarboxylation followed by protonation of carborane. The reductive elimination of HOPiv is the regioselectivity determining step, and the non‐covalent interaction analysis discloses that it is the steric repulsion of the methyl on C(1) atom of carborane towards the iridacycle and the Cp* group that causes the higher barrier for the B(3)–H activation, which finally leads to the specific B(4)–H functionalization.
Higher‐Order Spatially Squeezed Beam for Enhanced Spatial Measurements
Authors: Li Zhi , Guo Hui , Liu Hongbo , Li Jiaming , Sun Hengxin , Yang Rongguo , Liu Kui , Gao Jiangrui 
Published: September 2022

AbstractA scheme is proposed to realize high‐precision spatial measurement of laser beams beyond quantum limit using a novel quantum state called the order spatially squeezed state, which is the combination of a bright mode coherent state and squeezed vacuum mode state. An effective technique for the generation of a rectangular shape higher‐order mode squeezed light with a maximum mode order of 5 is experimentally demonstrated using a doubling resonated optical parametric amplifier. Furthermore, the fourth order tilt‐ and displacement‐squeezed beams are constructed and used to perform spatial tilt and displacement measurements, thereby improving the signal‐to‐noise ratio by 10 and 8.6 dB compared to the mode. The results indicate that high‐order spatially squeezed states enhance measurement precision beyond the shot noise limit and are more prominent in back‐action noise reduction. High‐precision spatial measurement has potential practical applications in high‐sensitivity atomic force microscope and super‐resolution quantum imaging.
Simultaneous determination of phthalates and bisphenols from plastic bottled water samples by dispersive solid‐phase extraction with multiwalled carbon nanotubes and liquid chromatography/atmospheric pressure photoionization/high‐resolution mass spectrometry
Authors: Sreedhashyam Haripriya , Mehtab Vazida , Chenna Sumana , Upadhyayula Vijayasarathi V. R. 
Published: September 2022

RationalePhthalates and bisphenols were reported as endocrine disrupting chemicals and hence a potential threat to human health. Polyethylene terephthalate bottles are being used to store drinking water and the probability of migration of phthalates and bisphenols from the bottles into the water is high. The migration of analytes with respect to different storage conditions need to be studied.MethodA sensitive analytical method for simultaneous determination of seven phthalates and three bisphenols from packaged drinking water was developed using liquid chromatography/atmospheric pressure photoionization/high‐resolution mass spectrometry. The analytes were extracted by dispersive solid‐phase extraction by multiwalled carbon nanotubes.ResultsThe developed method showed linearity from 0.5 to 5000 μg/L with the limit of detection and limit of quantification ranging from 0.5 to 1 μg/L and 1 to 2 μg/L, respectively, for phthalates and bisphenols. The inter‐ and intraday variations were below 10%. The recoveries were in the range of 79.5% to 112%. The migration of phthalates and bisphenols increased with storage time and temperature. Maximum migration was observed for diisobutyl phthalate of 1209.7 ng/L followed by dibutyl phthalate at 777.8 ng/L on 180 days of analysis at room temperature. Migration of bis(2‐ethylhexyl) phthalate was observed to be higher at elevated temperatures, increasing from 14.9 to 514 ng/L. Similarly, migration of bisphenol‐A was increased at 45°C. The results were subjected to analysis of variance (ANOVA) studies and the results showed significant variations of phthalates and bisphenols with respect to storage temperature and time.ConclusionThe use of atmospheric pressure photoionization facilitated simultaneous determination of phthalates and bisphenols. The migration of phthalates and bisphenols increased with increasing temperature and storage time. Maximum migration was observed for diethyl, diisobutyl, dibutyl and bis(2‐ethylhexyl) phthalates. This may be attributed to the type of plastic, the processing parameters and recycling.
Machine learning and neural network based model predictions of soybean export shares from US Gulf to China
Authors: Awasthi Shantanu , SenGupta Indranil , Wilson William , Lakkakula Prithviraj 
Published: September 2022

AbstractIn this paper, we propose a general model for the soybean export market share dynamics and provide several theoretical analyses related to a special case of the general model. We implement machine and neural network algorithms to train, analyze, and predict US Gulf soybean market shares (target variable) to China using weekly time series data consisting of several features between January 6, 2012 and January 3, 2020. Overall, the results indicate that US Gulf soybean market shares to China are volatile and can be effectively explained (predicted) using a set of logical input variables. Some of the variables, including shipments due at US Gulf port in 10 days, cost of transporting soybean shipments via barge at Mid‐Mississippi, and soybean exports loaded at US Gulf port in the past 7 days, and binary variables have shown significant influence in predicting soybean market shares.
Boreognathus pogorevichi, a remarkable new polychaete annelid from the lower Permian of the Pechora Basin, Russia
Authors: Shcherbakov Dmitry E. , Tzetlin Alexander B. , Zhuravlev Andrey Yu. 
Published: September 2022

AbstractThe sclerotized jaw elements (scolecodonts) of polychaete annelids are rarely preserved as articulated jaw apparatuses. Here we describe a morphologically unusual, rather large, and symmetrical jaw apparatus, assigned to the new taxon Boreognathus pogorevichi gen. et sp. nov., from the Kungurian (lower Permian) of the Pechora Coal Basin, northern Cis‐Urals, Russia. Whereas the specimen is mainly preserved as a three‐dimensional external mould of the near‐complete dorsal maxillary apparatus, some organic matter comprising the original jaw wall is also retained. The new taxon combines edentate, pincer‐like first maxillae (MI) typical of the extant Labidognatha apparatus type with long slender carriers common in the Prionognatha type. Unlike the smooth MI, MII are consistently and prominently denticulated. The new genus represents a hitherto unknown type of polychaete jaw apparatus and is assigned to the Palaeozoic family Atraktoprionidae.
Creating Anti‐Oppressive Digital Spaces for Social Justice Language Education
Authors: Ortaçtepe Hart Deniz 
Published: September 2022

AbstractContemporary moves towards social justice education and digital pedagogies require language educators to examine the ways digital learning platforms reinforce economic, social, and cultural inequities, and to explore how to instead offer anti‐oppressive pedagogies for diverse online communities. In this Teaching Issues essay, I draw from the principles of critical pedagogy to argue that non‐linear, non‐modular and multimodal digital learning platforms created on content‐management systems (CMS) can provide anti‐oppressive pedagogical affordances for 1) dismantling teacher‐student power relations, 2) cultivating a sense of a digital learning community, and 3) promoting intersectionality within language teacher education programs. Next, I present a discussion of the challenges involved in designing an anti‐oppressive, transformative digital learning space, and of several critical questions teacher educators can reflect upon while designing their own virtual environments.
Assessing winter habitat selection by river otters using aerial surveys
Authors: Taylor Janelle M. , Crimmins Shawn M. , Roberts Nathan M. 
Published: September 2022

AbstractRiver otters (Lontra canadensis) are widespread in the United States and are managed for sustainable fur harvest throughout much of their range in the United States. Despite their widespread distribution, river otters can be difficult to monitor due to their cryptic nature and the inaccessible habitats they often occupy. Additionally, there has been little research conducted to quantify winter habitat selection patterns of river otters. We used 4 years of aerial survey data conducted during the winter to quantify habitat selection patterns of river otters in Wisconsin, USA, and to determine factors associated with survey efficacy. We used a mixed‐effects logistic regression framework to evaluate habitat and anthropogenic factors at 2 spatial scales. We found that river otters were positively associated with the amount of forested and wetland habitat within a 1 km buffer around sampling locations, but that no factors we measured were influential at a local (100 m) scale. River otters were more likely to be detected when ice cover was only partial as opposed to when ice coverage was complete or when it was completely absent. Our results suggested that river otter habitat selection in Wisconsin is not strongly affected by anthropogenic influences but instead by broad‐scale habitat configuration. Furthermore, our results suggested that aerial survey approaches for river otters can be optimized by conducting surveys during periods when ice coverage is sufficient to allow for clear tracking substrate without being prevalent enough to limit movements into and out of corresponding aquatic habitats.
Holographic perspectives on models of moduli stabilization in M-theory
Authors: Ning Sirui 
Published: September 2022

Abstract
Recent holographic analyses on IIA and IIB models of moduli stabilization have led to many interesting results. Here we extend this approach to M-Theory. We consider both flux-stabilized models and non-perturbative stabilization methods. We perform a holographic analysis to determine the spectrum of the assumed dual CFT3 to see its AdS/CFT implication. For the flux stabilization, which relies on a large complex Chern-Simons invariant, moduli have integer dimensions similar to the DGKT flux-stabilized model in type IIA. For the non-perturbative stabilization, the results are similar to racetrack models in type IIB.
Inclusive J/ψ photoproduction at the ILC within the framework of non-relativistic QCD
Authors: Zhan Xi-Jie , Wu Xing-Gang , Zheng Xu-Chang 
Published: September 2022

Abstract
Based on the non-relativistic quantum chromodynamics factorization framework, we study the inclusive J/ψ photoproduction at the future high energy e+e− collider, International Linear Collider(ILC), where the initial photons come from the back-scattering of laser and electron (positron). The intermediate states, $$ c\overline{c} $$
c

c
¯

(3$$ {S}_1^{\left[\mathbf{1}\right]} $$

S
1

1

,1$$ {S}_0^{\left[\mathbf{8}\right]} $$

S
0

8

,3$$ {S}_1^{\left[\mathbf{8}\right]} $$

S
1

8

, 3$$ {P}_{0,1,2}^{\left[\mathbf{8}\right]} $$

P

0
,
1
,
2

8

), and resolved photoproduction processes are considered. Numerical results show that the cross section of J/ψ photoproduction at the ILC could be very large, and the single resolved pro- cess via $$ c\overline{c} $$
c

c
¯

(3$$ {S}_0^{\left[\mathbf{8}\right]} $$

S
0

8

) intermediate state dominates primarily the production. We also present various kinematic distributions for J/ψ photoproduction. Combining the high luminosity of the collision, J/ψ photoproduction at the ILC shall provide a good platform to test the NRQCD factorization.
Ozone ageing: experimental methods on pristine and protected natural rubber
Authors: Treib Caroline , Loos Klara , Johlitz Michael , Lion Alexander 
Published: September 2022

AbstractMany industrial applications require natural rubber (NR) as an irreplaceable polymer for its unique behaviour as its resistance to crack growth. The damage caused by ozone, seen as an ageing accelerator, influences the lifetime of rubber components. The data on ozone-induced ageing experiments are often incomplete or remain unpublished, whereas comprehensive databases for other environmental loads as oxygen do exist. A variety of experimental methods is used to investigate the ageing mechanism of ozone. The ultimate scope is to collect physically based data suitable to include it in thermo-mechanical modelling of the material’s full behaviour. Therefore, NR mixtures, without and with antiozonants: p-phenylenediamine (PPD) and paraffinic wax, are analysed. First, an accelerated, artificial ageing method is developed to reconstruct the real ageing in the laboratory. Experiments conducted henceforth are microhardness tests, uniaxial tensile tests and IR spectroscopy to determine the elastic modulus, the stress response and molecular change due to ageing. Independent of static deformation during the ageing process, both antiozonants show a significant protection effect up to the maximum loading with 75 pphm ozone concentration for 111 h at 50% relative humidity and 40 $$^\circ $$

∘

C. Paraffinic wax completely prevents measureable mechanical change and no surface cracks are visible, though IR spectra reveal ageing-induced molecular reactions, whereas the pristine and soley 6PPD protected compounds are clearly distinguishable by their surface crack picture. Neither of the material compounds, loaded with or without strain during ozone-ageing, contains cracks of a depth further than 300 $$\upmu {\textrm{m}}$$

μ
m

. The data generated on ozone ageing of rubber helps to distinguish it from thermo-oxidative ageing that is described comprehensively in the literature. In conclusion, the data proves the degradation and quantifies some characteristic material changes caused by ozone loading.
Uniqueness and Weak-BV Stability for $$2\times 2$$ Conservation Laws
Authors: Chen Geng , Krupa Sam G. , Vasseur Alexis F. 
Published: September 2022

AbstractLet a 1-d system of hyperbolic conservation laws, with two unknowns, be endowed with a convex entropy. We consider the family of smallBVfunctions which are global solutions of this equation. For any smallBVinitial data, such global solutions are known to exist. Moreover, they are known to be unique amongBVsolutions verifying either the so-called Tame Oscillation Condition, or the Bounded Variation Condition on space-like curves. In this paper, we show that these solutions are stable in a larger class of weak (and possibly not evenBV) solutions of the system. This result extends the classical weak-strong uniqueness results which allow comparison to a smooth solution. Indeed our result extends these results to a weak-BVuniqueness result, where only one of the solutions is supposed to be smallBV, and the other solution can come from a large class. As a consequence of our result, the Tame Oscillation Condition, and the Bounded Variation Condition on space-like curves are not necessary for the uniqueness of solutions in theBVtheory, in the case of systems with 2 unknowns. The method is$$L^2$$L2based, and builds up from the theory of a-contraction with shifts, where suitable weight functionsaare generated via the front tracking method.