bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health literacy among long-term survivors of breast cancer; exploring associated factors in a nationwide sample
Authors: Vandraas Kathrine F. , Reinertsen Kristin V. , Kiserud Cecilie E. , Bøhn Synne K. , Lie Hanne C. 
Published: June 2022

AbstractBackgroundPoor health literacy may hamper health management and long-term outcomes in breast cancer survivorship. Knowledge of factors associated with poor health literacy is needed to identify survivors in need of additional support and to improve the quality of health care, but is currently scant. Here, we explore health literacy and associated factors in a nationwide sample of long-term survivors of breast cancer.Material and methodsAll survivors aged 20–65 years when diagnosed with stage I–III breast cancer in 2011 or 2012 were identified through the Norwegian Cancer Registry, and invited to participate in the Survivorship, Work and Sexual Health (SWEET) study. Health literacy was measured using The European Health Literacy Survey Questionnaire-12 (HLS-EU-Q12) and analyzed as a continuous and categorical variable. Associations between health literacy and socioeconomic, physical, and mental health variables, including the most common late effects after cancer treatment, were explored in uni- and multivariable linear regression models.ResultsThe final sample consisted of 1355 survivors (48%) with a mean age of 60 years at survey (SD 8.7). Eight years had passed since diagnosis (SD.0.7), and the majority of survivors had high socioeconomic status. Advanced judgment calls concerning treatment and health risks were reported to be the most difficult for survivors to handle. Mean health literacy sum score was 36.2 (range 12–48, SD 5.4). Thirty-nine percent had intermediate, while 19.3% reported marginal or inadequate health literacy. Education, income, age at diagnosis, the personality trait neuroticism, and fear of cancer recurrence were significantly associated with health literacy in the multivariate model, explaining 12% of the variance in health literacy scores.ConclusionLow levels of health literacy were prevalent in this population-based sample of long-term survivors of breast cancer, despite high socioeconomic status. Communicating and interpreting risks seem to be especially challenging. Attention to health literacy at a societal and individual level is necessary in order to provide survivorship care of high quality.
Management of malignant cutaneous wounds in oncologic patients
Authors: Starace Michela , Carpanese Miriam Anna , Pampaloni Francesca , Dika Emi , Pileri Alessandro , Rubino Daniela , Alessandrini Aurora , Zamagni Claudio , Baraldi Carlotta , Misciali Cosimo , Patrizi Annalisa , Bianchi Tommaso , Apalla Zoe , Piraccini Bianca Maria 
Published: June 2022

Abstract

Purpose
Neoplastic wounds may develop as a result of primary tumor growth in the skin, due to metastasis, or due to skin invasion by tumors emerging from deeper levels. Malignant wounds may present as a crater-like ulcer, or as raised nodules with a cauliflower-like appearance. They are associated with malodor, necrosis, pain, bleeding, and secondary infection. The aim of our study is to better characterize fungating wounds and their management.

Methods
We retrospectively reviewed the database of the Wound Care Unit of the University of Bologna in order to identify individuals affected by neoplastic wound, between January 2019 and February 2021.

Results
We identified 9 females and 2 males with a mean age of 63 years; all were referred by the Oncology Unit. Management differed depending on the characteristics of the patients and the ulcers. Complete healing of the wound, following the parallel complete remission of the lymphoproliferative neoplasia, was observed in one individual. Among the others, one died because of breast cancer, while cutaneous lesions in 2 individuals deteriorated after 1 year of follow-up. Remission/relapse of the ulcer following the treatment course administered for the lymphoma were observed in one patient.

Conclusions
Treatment of malignant fungating wounds is challenging. Considering the neoplastic nature of the wounds, complete healing or improvement cannot be expected with the application of classically prescribed dressing for wounds. A mostly palliative treatment, focusing on maintaining the patient’s quality of life, is a reasonable choice.
Reconnaissance of the Diquini and Mariani springs and insights regarding the Massif de la Selle karst aquifer of Haiti
Authors: Miner Wm Javan , Adamson James K. , Rochat Pierre-Yves 
Published: June 2022

AbstractA reconnaissance was performed for Tunnel Diquini and Source Mariani in the metropolitan region of Port-au-Prince, Haiti, to address concerns of decreasing flows and to evaluate potential impacts of a proposed river diversion scheme in the study area. The tunnel and spring are the two largest water sources serving the Port-au-Prince municipal water system and discharge from the Massif de la Selle carbonate aquifer. Considering their significance and importance to the water security of the region, there are limited data or studies specific to the water sources. An introductory framework was established regarding the flow regimes, the origin of waters, and recharge dynamics of the sources. Field reconnaissance and stable-isotope, tracer, and chloride-mass-balance techniques were applied to strengthen the conceptual understanding of the water sources. Recharge to this portion of the Massif de la Selle carbonate aquifer is variable depending on monthly rainfall intensity and 3–7-year climatic cycles. Rather than a consistent long-term decreasing flow trend, a particularly intense period from 2007 through 2010 resulted in the highest flows on record, which have steadily recessed to historical norms in recent years. The recharge characteristics and catchment areas indicate that neither water source is connected to the River Momance; however, a connection to the River Froide is possible, particularly related to the tunnel. Finally, recharge rates and an estimate of renewable groundwater in the Massif de la Selle show the regional significance and importance of the carbonate aquifer for current supplies and future water development.
Efficacy and safety of ixekizumab in patients with active psoriatic arthritis with and without concomitant conventional disease-modifying antirheumatic drugs: SPIRIT-P1 and SPIRIT-P2 3-year results
Authors: Coates Laura C. , Mease Philip , Kronbergs Andris , Helt Cameron , Sandoval David , Park So Young , Combe Bernard , Nash Peter , Deodhar Atul 
Published: June 2022

Abstract

Introduction/objectives
To evaluate the three-year efficacy and safety of ixekizumab with and without concomitant conventional synthetic disease-modifying antirheumatic drug (csDMARD) use in patients with active psoriatic arthritis (PsA).

Method
Patients with PsA who were biologic-naïve (SPIRIT-P1, NCT01695239) or had prior inadequate response to tumor necrosis factor inhibitors (SPIRIT-P2, NCT02349295) were randomized to receive 80-mg ixekizumab every four weeks after receiving 160-mg ixekizumab at baseline. Efficacy, safety, and immunogenicity were evaluated in this post-hoc analysis in three subgroups: (1) ixekizumab monotherapy, (2) ixekizumab and methotrexate (MTX), (3) ixekizumab and any csDMARD (including MTX). Missing data were imputed using multiple imputation for continuous variables and modified non-responder imputation for categorical variables.

Results
Efficacy was similar across the three subgroups with 59.1%, 67.0%, and 66.1% of ixekizumab-treated patients achieving 20% improvement in the American College of Rheumatology scale score at week 156. Radiographic progression of structural joint damage (SPIRIT-P1 only) was similarly inhibited across the three subgroups with several outliers. No new safety signals were reported, and 91.0%, 84.1%, and 83.2% in the three subgroups reported ≥ 1 treatment-emergent adverse event. At week 156, 15.9%, 13.1%, and 11.0% in the three subgroups had antidrug antibodies; most had low titer status.

Conclusions
Ixekizumab showed sustained efficacy in treating patients with PsA for up to three years in monotherapy or in combination with MTX or any csDMARD. The three subgroups had similar safety and immunogenicity profiles, which supports that the use of concomitant MTX or csDMARDs does not seem to impact the benefit/risk profile of ixekizumab.

Key Points• Ixekizumab treatment led to improved clinical responses over time when used as monotherapy or in combination with concomitant MTX or any concomitant csDMARD (including MTX) in patients with active PsA.• Ixekizumab monotherapy has similar radiographic efficacy as ixekizumab with MTX or ixekizumab with other csDMARDs (including MTX); similar inhibition of radiographic progression was observed between the subgroups of patients receiving ixekizumab monotherapy or ixekizumab with MTX or other csDMARDs.• The long-term safety profile of ixekizumab used as monotherapy or in combination with MTX or any other csDMARDs is consistent with what has been previously reported. The addition of MTX or any csDMARD to ixekizumab treatment did not negatively impact the favorable long-term safety profile of ixekizumab.
Metacognitive judgments can potentiate new learning: The role of covert retrieval
Authors: Kubik Veit , Koslowski Kenneth , Schubert Torsten , Aslan Alp 
Published: June 2022

AbstractInterim tests of previously studied information can potentiate subsequent learning of new information, in part, because retrieval-based processes help to reduce proactive interference from previously learned information. We hypothesized that an effect similar to this forward testing effect would also occur when making judgments of (prior) learning (JOLs). Previous research showed that making JOLs likely prompts covert retrieval attempts and thereby enhances memory, specifically when providing only parts of previously studied information. This study examined the forward effect of different types of JOLs (i.e., with complete or partial prior study information available) on subsequent learning of new materials, compared to restudy and retrieval practice. In a between-subjects design, participants (N = 161) consecutively studied five lists of 20 words with the aim to recall as many of them on a final cumulative recall test. After the presentation of each of the first four lists, participants either restudied the list, made JOLs with complete words, made JOLs with word stems, or they were tested on word stems. Compared to restudy, practicing retrieval and making JOLs with word stems, but not JOLs with complete words, facilitated the List-5 interim recall performance and attenuated the number of intrusions from prior lists. The findings suggest that, similar to overt retrieval, making JOLs with incomplete information can enhance new learning to the extent that it elicits covert retrieval attempts.
Enhancing the properties of bone China ceramics by treatment with microporous SiO2 nanoparticles
Authors: Abou Elmaaty Tarek M. , Sayed-Ahmed Khaled , El Gohari Mohamed M. , Noaman Rokaya 
Published: June 2022

AbstractIn this study, microporous silicon dioxide nanoparticles (SiO2–NPs) were used to improve the physical, chemical, and mechanical properties of bone China ceramics. Microporous SiO2–NPs were prepared economically from sodium metasilicate (SMS) as a precursor with cetyltrimethylammonium bromide (CTAB) as a surfactant at different concentrations. The prepared SiO2–NPs were characterized using scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and Raman spectroscopy to confirm the formation of microporous SiO2–NPs. The optimum concentrations of the precursor and surfactant used in the SiO2–NPs synthesis were set to be 1.5% and 2 g/200 ml, with a size range of 7–96 nm. SiO2–NPs prepared at the optimum concentrations were incorporated into bone China at different concentrations to evaluate their effect on flexural strength and elasticity. The bone China prepared using 1% SiO2–NPs (B1) had the highest flexural strength and Young's modulus values. Sample characteristics, including self-cleaning, differential scanning calorimetry, thermogravimetric analysis, bulk density (BD), apparent porosity (AP), and water absorption (WA), were investigated. The results revealed outstanding characteristic such as self-cleaning ability, remarkable increase in AP and WA, and a decrease in BD.
The impact of convexity on expansion planning in low-carbon electricity markets
Authors: Wogrin S. , Tejada-Arango D. , Delikaraoglou S. , Lamadrid A. , Botterud A. 
Published: June 2022

AbstractExpansion planning models are tools frequently employed to analyze the transition to a carbon-neutral power system. Such models provide estimates for an optimal technology mix and optimal operating decisions, but they are also often used to obtain prices and subsequently calculate profits. This paper analyzes the impact of modeling assumptions on convexity for power system outcomes and, in particular, on investment cost recovery. Through a case study, we find that although there is a long-term equilibrium for producers under convex models, introducing realistic constraints, such as non-convexities/lumpiness of investments, inelastic demand or unit commitment constraints, leads to profitability challenges. We furthermore demonstrate that considering only short-term marginal costs in market-clearing may potentially create a significant missing-money problem caused by a missing-market problem and dual degeneracy in a 100 percent renewable system.
Stability Improvement of Methylammonium Lead Iodide Perovskite Thin Films by Bismuth Doping
Authors: Marí-Guaita Julia , Bouich Amal , Marí Bernabé 
Published: June 2022

AbstractPerovskites have been in the spotlight in the field of solar cells due to their high efficiency and their low cost of materials and fabrication processes. Perovskite solar cells (PSCs) have shown an efficiency of up to 25%. Nevertheless, PSCs have some drawbacks such as rapid degradation in ambient conditions. To improve PSC stability, lead is usually replaced with bismuth. In this article, we report the results when doping the methylammonium lead iodide (CH3NH3)PbI3, aka MAPbI3, with different bismuth quantities. The incorporation of bismuth into the lattice leads to a remarkable change in optoelectronics and morphological structure. Substituting lead atoms with 2% bismuth improves some characteristics of MAPbI3 layers, such as removing pinholes and increasing crystallite size and optical absorption. Furthermore, bismuth doping improves the stability of pure MAPbI3 layers, which after 4 weeks exhibits higher degradation compared to bismuth-doped MAPbI3 samples, which remain stable after that period.
Muscle Protein Synthesis Responses Following Aerobic-Based Exercise or High-Intensity Interval Training with or Without Protein Ingestion: A Systematic Review
Authors: Bagheri Reza , Robinson Isabelle , Moradi Sajjad , Purcell Jessica , Schwab Elita , Silva Tharindie , Baker Brooke , Camera Donny M. 
Published: June 2022

Abstract
Background
Systematic investigation of muscle protein synthesis (MPS) responses with or without protein ingestion has been largely limited to resistance training.

Objective
This systematic review determined the capacity for aerobic-based exercise or high-intensity interval training (HIIT) to stimulate post-exercise rates of MPS and whether protein ingestion further significantly increases MPS compared with placebo.

Methods
Three separate models analysed rates of either mixed, myofibrillar, sarcoplasmic, or mitochondrial protein synthesis (PS) following aerobic-based exercise or HIIT: Model 1 (n = 9 studies), no protein ingestion; Model 2 (n = 7 studies), peri-exercise protein ingestion with no placebo comparison; Model 3 (n = 14 studies), peri-exercise protein ingestion with placebo comparison.

Results
Eight of nine studies and all seven studies in Models 1 and 2, respectively, demonstrated significant post-exercise increases in either mixed or a specific muscle protein pool. Model 3 observed significantly greater MPS responses with protein compared with placebo in either mixed or a specific muscle fraction in 7 of 14 studies. Seven studies showed no difference in MPS between protein and placebo, while three studies reported no significant increases in mitochondrial PS with protein compared with placebo.

Conclusion
Most studies reporting significant increases in MPS were confined to mixed and myofibrillar PS that may facilitate power generating capacity of working skeletal muscle with aerobic-based exercise and HIIT. Only three of eight studies demonstrated significant increases in mitochondrial PS post-exercise, with no further benefits of protein ingestion. This lack of change may be explained by the acute analysis window in most studies and apparent latency in exercise-induced stimulation of mitochondrial PS.
The functional extracellular matrix on the regulation of odontogenic differentiation of stem cells
Authors: Yang Haoqing , Fan Zhipeng 
Published: June 2022

AbstractDental defects and loss are common oral diseases that seriously affect the chewing efficiency of patients and thereby affect their health. With the development of tissue engineering technology, dental tissue regeneration has emerged as a promising technique. Cell type, extracellular matrix (ECM) environment, cytokines and other factors which affect odontogenic differentiation and dental tissue regeneration have aroused significant interest. The functional ECM consists of extracellular components that control the initiation and growth of crystal deposition and regulate the differentiation and regeneration of endogenous or exogenous stem cells in the defect site. At present, the function and regulatory mechanism of the functional ECM in this process remain poorly understood. Therefore, elucidating the effect of the functional ECM on odontogenic differentiation and its mechanism has great scientific significance and potential clinical application. This review explored functional ECM components involved in odontogenic differentiation and dental tissue regeneration.
Secondary school teacher’s conception and reflection of computer programming with Scratch
Authors: Iyamuremye Aloys , Nsabayezu Ezechiel , Habimana Jean Claude 
Published: June 2022

AbstractThe present study explores teachers' conception and reflection of computer programming with a Scratch in terms of technological and pedagogical aspects. A mixed research approach specifically sequential explanatory research design was used to collect quantitative and qualitative data. The population was comprised of two hundred and four in-service Mathematics, Chemistry, Physics, and Biology teachers from Kayonza district, Rwanda. However, only 34 were randomly selected to participate in the study. An achievement test and structured interview were used to collect quantitative and qualitative data, respectively. The quantitative data obtained from pre- and post-tests were analyzed using a pairedttest, and the data from the interview was analyzed by descriptive, and interpretive analyses. It was revealed that secondary school teachers have a respectable conception and constructive reflection of Scratch programming once attending scratch training. Quantitative findings showed that there was an important difference in the mean among pre- and post-tests with 0.171 learning gain and an effect size of 0.53 (df = 33,p < 0.05). It was also revealed that Scratch is an operational instructional tool for teaching and learning Mathematics and Sciences. Furthermore, teachers articulated progressive views of using scratch in teaching and learning Mathematics and Sciences as it supports them to visualize abstract content, improves students' interest and impetus, critical thinking, and problem-solving skills, and acts as an assessment tool.
Tixagevimab and Cilgavimab: Can we see More Recommendations for Monoclonal Antibodies Beyond COVID-19 Vaccination
Authors: Anmar Al-Taie 
Published: June 2022

AbstractNearly 3 years after its detection, the coronavirus disease 2019 (COVID-19) which is caused by severe acute respiratory syndrome CoV-2, is still a life-threatening global pandemic that has contributed to a high progression and mortality rate across the globe. This imposes the need for scientific research efforts in order to hold intense interest directed towards such exploration, for the development and optimization of different interventions to the COVID-19 infection. This commentary summarizes the potential clinical benefits for the recently authorized immunotherapy combination of Tixagevimab and Cilgavimab monoclonal antibodies for the prevention and treatment of COVID-19.
Cluster categories of formal DG algebras and singularity categories
Authors: Hanihara Norihiro 
Published: June 2022

AbstractGiven a negatively graded Calabi-Yau algebra, we regard it as a DG algebra with vanishing differentials and study its cluster category. We show that this DG algebra is sign-twisted Calabi-Yau and realise its cluster category as a triangulated hull of an orbit category of a derived category and as the singularity category of a finite-dimensional Iwanaga-Gorenstein algebra. Along the way, we give two results that stand on their own. First, we show that the derived category of coherent sheaves over a Calabi-Yau algebra has a natural cluster tilting subcategory whose dimension is determined by the Calabi-Yau dimension and thea-invariant of the algebra. Second, we prove that two DG orbit categories obtained from a DG endofunctor and its homotopy inverse are quasi-equivalent. As an application, we show that the higher cluster category of a higher representation infinite algebra is triangle equivalent to the singularity category of an Iwanaga-Gorenstein algebra, which is explicitly described. Also, we demonstrate that our results generalise the context of Keller–Murfet–Van den Bergh on the derived orbit category involving a square root of the AR translation.
A Promising Start and Frustrating End: The Rise and Fall of the Economic History Department, University of Zimbabwe
Authors: Kufakurinani Ushehwedu 
Published: June 2022

AbstractThe paper explores the internal dynamics of knowledge production at the University of Zimbabwe. I introduce the term epistuicide to refer to situations where a people destroy their own knowledge systems. I use this term in contrast to what have been called epistimicides—that is, the killing of a peoples’ knowledge systems by another. In this paper, I demonstrate how the history of the Economic History Department is a classic case of epistuicide, as a flipside to epistimicides. It is a history of not only unrecognized effort but also of how internal dynamics and systems derail rather than promote knowledge production. From its inception, the Department of Economic History faced onslaughts which heightened in the new millennium. Admittedly, there are pockets of successes to record, such as the expansion of the teaching of the discipline to secondary schools and growing recognition of economic historians locally.