bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autism and anorexia nervosa: longitudinal prediction of eating disorder outcomes
Authors: Leppanen Jenni , Sedgewick Felicity , Halls Daniel , Tchanturia Kate 
Published: July 2022

Abstract
Background: Recently, elevated levels of autistic traits and autism diagnoses have been reported among people with anorexia nervosa (AN). In clinical settings high levels of autistic traits have been linked to more complex, highly comorbid illness presentation and poorer outcome. This study aimed to examine whether autistic traits predict AN symptom profile in long term. Methods: Altogether 118 women with lived experience of AN completed two autism assessments at time 1, the Autism Diagnostic Observation Schedule (ADOS) and the short version of the Autism Quotient (AQ10). Measures assessing AN symptom profile, including eating disorders symptoms, anxiety, depression, OCD symptoms, and BMI, were also recorded. The symptom profile measures were administered again 6 months and 2 years later. We conducted two analyses to examine the extent to which the ADOS and AQ10 scores predicted broad AN symptom profile at each three time points.Results: Overall, high levels of autistic traits were consistently associated with worse psychological symptoms, but not BMI, across all time points. Both the analysis using baseline ADOS scores and self-reported AQ10 scores showed similar pattern. Limitations: The sample consisted of young women only and it is therefore, difficult to ascertain whether these findings extend to other genders. Additionally, 70% of the participants who completed the self-report questionnaires at Time 1 also agreed to undergo ADOS assessment. This may have limited the power of the analysis involving ADOS scores compared to the analysis using AQ10 scores. Conclusions: The present findings solidify previously reported associations between autistic traits and worse psychological outcome among people with AN. The findings also suggest that self-report measures may be sufficient for assessing autistic traits among people with AN. Importantly, the study highlights the need for development and further investigation of neurodiversity accommodations in the treatment of AN.
Extracellular HSP90α inhibits ferroptosis through GPX4 in NSCLC cells
Authors: Wan Xuan , Wang Jiajian , Du Jiangzhou , Fang Yuting , Dong HangMing , Cai Shaoxi 
Published: July 2022

Abstract
Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer in the world. Extracellular HSP90α (eHSP90α) promotes epithelial–mesenchymal transition (EMT) and leads to NSCLC resistance in combination with targeted drugs. However, the molecular mechanism by which HSP90α induces EMT is unclear.Here, we used the STRING database to screen for proteins that interact with HSP90α in lung cancer cells, and found that the relationship between HSP90α and GPX4 is essential for ferroptosis in NSCLC cells. We also found that extracellular HSP90α increased E-cadherin expression by silencing LRP1 with siRNA, while decreased N-cadherin, Vimentin, and GPX4 expression, eHSP90α promoted EMT and inhibited ferroptosis by upregulating GPX4. We further found that hrHSP90α and TGF-β1 inhibited ferroptosis.The AKT signaling pathway was involved in eHSP90α-inhibited EMT. Meanwhile, we also confirmed that Ferrostatin-1 and hrHSP90α accelerated gefitinib resistance.These findings suggest that eHSP90α promoted EMT through LRP1 and inhibited ferroptosis by upregulating GPX4 in NSCLC cells. There may be mutual regulation between EMT and ferroptosis, and ferroptosis-inducing therapy may provide a new treatment strategy for gefitinib-resistant NSCLC.
Directions in fuzzy relation equations: conclusions from the current state of the art
Authors: Małgorzata Rataj , Matusiewicz Zofia 
Published: July 2022

Abstract
In our paper, we analyze those aspects of the research area thathave been most popular and we examine the relationships between the various sub-disciplines in thefield. We identify publications and authors that have influenced the development of the discipline, aswell as research institutes and groups that specialize in given research topics. Our work aims notonly to analyze current developments, but also to outline opportunities for collaboration betweenResearchers, to identify major scientific breakthroughs, identify the centers developing fuzzyrelational equations, and identify authors with significant achievements in the discipline. The maingoal of this analysis is to establish opportunities for developing a model and a computer applicationbased on existing scientific work.Our analysis shows that the main centres developing fuzzy set relation equations are located inthe Islamic Azad University in Iran, the University of Ostrava in the Czech Republic and Hanshan Normal University in China.Furthermore, the leading mentors of our time arePedrycz, Khorram, Stepnicka, and Jafari.In addition, important articles have been published byDrewniak, Higashi, Klir, Molai, Pervilieva, Sessa, Shieh.
Improvement of Body Image Flexibility in Adolescent Female Athletes undergoing Education about Nutrition and Body Image
Authors: Vidlock Kathryn , Liggett Catherine , Oberlag Nicole 
Published: July 2022

Abstract
Background and Aims: To evaluate the efficacy of an educational program in adolescent female athletes in increasing body image flexibility.Methods: A cohort with pre and posttests was done measuring body image flexibility in adolescent female athletes. Athletes participated in educational sessions about nutrition, body image flexibility, and RED-S (relative energy deficiency in sport). Body image flexibility was measured by the BI-AAQ (Body Image – Acceptance and Action Questionnaire).Results: Increases were shown in all teams and overall. Specifically, mean BI-AAQ scores from 45.2 to 57.2 or difference of 12.0 (p-value <0.01). The cheer team showed an increase of the mean scores from 42.3 to 52.0 or difference of 9.7 (p-value 0.033). Overall scores improved from 43.6 to 54.1 or difference of 10.4 (p-value <0.01). Individual questions results shows that the cross country/track team had significant improvement in 8 of the 12 questions and the cheer team had significant improvement in 4 of the 12 questions.Discussion: This prospective cohort study examined the efficacy of three educational sessions during the athletic season. The positive outcomes in the short educational sessions suggest that starting education early may help with the mindset of positive body image flexibility at least short term.Conclusion: There was statistically significant short term increase in body image flexibility in adolescent female athletes with education about body image, performance, and nutrition. Registration Clinicaltrial.gov # NCT05222360
Docetaxel chemotherapy plus androgen-deprivation therapy in high-volume disease metastatic hormone-sensitive prostate cancer in Chinese patients: an efficacy and safety analysis
Authors: Guo Zhuifeng , Lu Xuwei , Yang Fan , Qin Liang , Yang Ning , Wu Jiawen , Wang Hang 
Published: July 2022

Abstract
Objective：To investigate the efficacy and safety of docetaxel chemotherapy combined with androgen-deprivation therapy for patients with high-volume disease metastatic hormone-sensitive prostate cancer. Methods: 153 cases of high-volume disease metastatic hormone-sensitive prostate cancer in Minhang Hospital between January 2018 to December 2019 were analyzed retrospectively, including the number of patients, age, initial PSA level, gleason score, TNM stage and ECOG score. 90 patients in the endocrine therapy group received continuous ADT, and 63 patients in the combined chemotherapy group received docetaxel plus ADT. The progression-free survival time (time from initiation of prostate cancer treatment to progression to CRPC), PSA response rate, and adverse reactions were compared between the two groups. Results: All 153 cases were closely followed up for a period of 12.3 to 35.3 months, with a median follow-up time of 23.5 months. The median time to reach the lowest point of PSA in the two groups was 6.3 months and 7.9 months (P = 0.018) in the combination chemotherapy group and the ADT group alone, with 27 (42.9%) and 12 (13.3%) cases in the two groups Within 12 months of treatment, PSA decreased to below 0.2ng / ml (P = 0.02), and progression-free survival was 16.9 months (6.5 to 28.5 months) and 11.2 months (4.3 to 22.7 months) in the two groups. (P＜0.001). There were 18 cases (28.6%) and 54 cases (60%) in the two groups with disease progression (P＜0.001). There were 6 cases (9.5%) and 15 cases (16.7%) in the combination chemotherapy group and the ADT group died of prostate cancer and related complications, respectively. All 63 cases in the combined chemotherapy group completed 6 cycles of chemotherapy. 39 (61.9%) cases experienced varying degrees of neutropenia, of which 12 (19%) experienced grade 3 to 4 neutropenia, with 6 cases (9.5%) developed febrile neutropenia. 30 cases (47.6%) had toxic reactions in the digestive system, and 3 case (4.3%) had grade 3 liver dysfunction. 27 cases (42.8%) had skin and mucosal toxicity. 9 cases (14.3%) had mild fluid retention. No blood and digestive toxicity were observed in the ADT group. 33 cases (52.4%) and 48 (53.3%) of the two groups had symptoms of afternoon hot flashes and fatigue, (P = 0.961). Conclusion: Docetaxel chemotherapy combined with endocrine therapy could be one of effective treatments for delaying castration resistance of HVD-mHSPC，which could prolong PFS effectively and obtain a higher PSA response rate, high safety under close monitoring, and controllable adverse reactions.
Laparoscopic Drainage Versus Interventional Radiology In Management Of Appendicular Abscess: A Randomized Controlled Trial
Authors: Negm Said , Mousa Bassam , Shafiq Ahmed , Abozaid Mohamed , Allah Ehab Abd , Attia Adel , Abozaid Eslam , Farag Ahmed 
Published: July 2022

Abstract
Background:
Laparoscopic drainage of appendicular abscess has become a novel technique due to its advantages over interventional & open surgery like complete exploration of the abdomen, exclusion of other pathologies, excision of the appendix at same session, better cosmoses, decrease incidence of wound infection & incisional hernia, better visualization of surgical field, fine handling of edematous tissue and drainage of multiple collections.
Methods:
This prospective randomized controlled clinical trial included all patients who developed the manifestations of appendicular abscess and referred to the Zagazig University Hospital Emergency Department between January 2020 and February 2022. The study was prospectively approved by Zagazig University Faculty of Medicine Institutional Review Board (Approval Number: 55342/24.1.2020), and was retrospectively submitted in clinicaltrials.gov in June 2022 (ClinicalTrials.gov ID: NCT05419440). The sample size was 172 patients divided into two equal group, laparoscopic group involved 86 patients (group1), interventional radiology group involved 86 patients (group2).
Results:
172 patients divided into equal groups, group (1) laparoscopic drainage group included 86 patients, 48(55.8%) patients of them were male, 38 (44.2%) patients were female, with the age of the patients range from 16–60 years with median of the age (41.2 ± 12.2), group (2) interventional radiology group included 86 patients, 44 (51.2%) patients were male, 42 (48.8%) patients were female, with age range from 16–60 years, with the median of age (36.8 ± 10.9). The complications in both groups were bowel injury, fecal fistula, recurrence, pelvic collection and mortality with incidence of occurrence 1(1.2%), 3 (3.5%), 0 (0%), 0 (0%), 0(0%) respectively in group (1) while in group(2) were 5(5.8%), 0(0%), 3(3.5%), 8(9.3%), 1(1.2%) respectively. Regarding quality of life in both groups were excellent, good, poor with incidence of 48(55.8%), 38(44.2%), 0(0%) respectively in group (1), and 12(14%), 59(68.6%), 15(17.4%) respectively in group(2).
Conclusion:
Laparoscopic management of appendicular abscess can be safely applied in a good experienced hand with no mortality & morbidity, without the need for interval appendectomy.
Characterization of Natural Hepatoprotectors and Added Foods by Photoacoustic Spectroscopy and Colorimetry
Authors: Saucedo-Alfonzo D. A. , Dominguez-Pacheco A. , Hernandez-Aguilar C. , Cruz-Orea A. 
Published: July 2022

Abstract
The current pandemic events make it necessary to develop foods with a higher content of nutrients that have a better impact on the health of the population. The improvement of daily food mixtures by adding nutraceutical materials with bioactive substances has a favorable effect on food products and consumers. In the present study, photoacoustic spectroscopy and colorimetry were used to characterize hepatoprotective plants and tortillas added with black radish (2 and 8%) and black radish and turmeric (3%). The main findings were: 1) Of the evaluated hepatoprotectants Silybum marianum, Peumus boldus and Raphanus sativus; the black radish peel is the one that presents the highest level of photoacoustic signal at the wavelength (250 -900 nm). 2) The “tortillas” characterized by PAS and colorimetry, presented a positive correlation between the photoacoustic signal at the wavelength of 450 nm. and the color variables a* and b*. Likewise, there is a correlation between the color parameter L* and the amplitude of the photoacoustic signal at the wavelength of 350 nm. 3). The dehydration process modifies the color of the tortilla, being the variable L*, the most affected and to a lesser degree a* and b*. The PAS technique and colometry permit the study of naturals hepatoprotectors, and blends of cornmeal added with black radish.
Political Dynasties and Corruption: Evidence from Brazil
Authors: Oliveira Savio Luan da Costa , Souza Wallace Patrick Santos de Farias 
Published: July 2022

Abstract
In this study, we investigate whether dynastic mayors are more or less likely to engage in corruption when compared to non-dynastic mayors. Using data from random government audits conducted in the Brazilian municipalities, we use RDD on close elections to compare municipalities that barely had a dynastic candidate elected as mayor to those that did not. The identification of relatives in politics is based on the matching of their last names. We find that dynastic mayors are more likely to engage in practices of over-invoicing compared to non-dynastic mayors.
Pangenome and genomic taxonomy analyses of Leuconostoc gelidum and Leuconostoc gasicomitatum
Authors: Johansson Per , Säde Elina , Hultman Jenni , Auvinen Petri , Björkroth Johanna 
Published: July 2022

Abstract
Background: Leuconostoc gelidum and Leuconostoc gasicomitatum have dual roles in foods. They may spoil cold-stored packaged foods but can also be beneficial in kimchi fermentation. The impact in food science as well as the limited number of publicly available genomes prompted us to create pangenomes and perform genomic taxonomy analyses starting from de novo sequencing of the genomes of 37 L. gelidum/L. gasicomitatum strains from our culture collection. Our aim was also to evaluate the recently proposed change in taxonomy as well as to study the genomes of strains that had have different lifestyles in foods. Methods: We selected as diverse a set of strains as possible in terms of sources, previously conducted genotyping results and geographical distribution, and included also 10 publicly available genomes in our analyses. We studied genomic taxonomy using pairwise average nucleotide identity (ANI) and calculation of digital DNA-DNA hybridisation (dDDH) scores. Phylogeny analyses were done using the core gene set of 1141 single-copy genes and a set of housekeeping genes commonly used for lactic acid bacteria. In addition, the pangenome and core genome sizes as well as some properties, such as acquired antimicrobial resistance (AMR), important due to the growth in foods, were analysed. Results: Genome relatedness indices and phylogenetic analyses supported the recently suggested classification that restores the taxonomic position of L. gelidum subsp. gasicomitatum back to the species level as L. gasicomitatum. Genome properties, such as size and coding potential, revealed limited intraspecies variation and showed no attribution to the source of isolation. Distribution of the unique genes between species and subspecies was not associated with the previously documented lifestyle in foods. None of the strains carried any acquired AMR genes or genes associated with any known form of virulence. Conclusion: Genome-wide examination of strains confirms that the proposition to restore the taxonomic position of L. gasicomitatum is justified. It further confirms that the distribution of L. gelidum and L. gasicomitatum between different foods or lifestyles is not a result of functional and phylogenetic diversification at the genome level. Thus, we consider that the distribution and lifestyle of L. gelidum and L. gasicomitatum in foods has not been driven by the evolution of functional and phylogenetic diversification detectable at the genome level.
Clinical characteristics of patients with diffuse alveolar hemorrhage diagnosed by cytological examination of 1000 bronchoalveolar lavage samples.
Authors: Prasad Pallavi , Gupta Aviral , Nath Alok , Hashim Zia , Khan Ajmal , Krishnani Narendra 
Published: July 2022

Abstract
Background and objective: Diffuse alveolar hemorrhage (DAH) is a life-threatening condition due to the extravasation of blood in the alveoli, resulting in hypoxemia and even acute respiratory distress syndrome. This study aimed to describe the clinico-radio-pathological profile of patients diagnosed with DAH and classify it into immune and nonimmune DAH.
Methods: This was a retrospective analytical study. Of a total of 1000 cases of bronchoalveolar lavage fluids (BALF) received for cytological examination, patients fulfilling the clinical, radiological, and laboratory details of cases satisfying the clinical and cytological criteria of DAH (n=47) were studied.
Results: The most common cause of immune DAH was ANCA-associated vasculitis (n=13, 27.6%), and that of nonimmune DAH was infections (n=10, 21.3%). Twenty-nine patients (61.7%) had hemoptysis. The most common radiological finding was ground-glass opacities (n=33, 70.2%). In univariate analysis, female sex, mean hemoglobin at admission, total leucocyte count (TLC), platelet count, and erythrocyte sedimentation rate (ESR) were significantly associated with immune-DAH. However, in multivariate analysis, female sex, higher TLC, high platelets, and high ESR were significantly associated with immune DAH. Patients were treated with corticosteroids (n=25, 46.3%), intravenous cyclophosphamide (n=12, 22.2%), plasma exchange (n=7, 13.0%), intravenous immunoglobulin (n=5, 9.3%) and rituximab (n=5, 9.3%). The overall mortality was 8.5% (n=4).
Conclusion: DAH is a life-threatening syndrome that may be classified into immune and nonimmune DAH. Immune-DAH requires aggressive management, whereas nonimmune DAH cases respond best to conservative management.
Teen dating violence interventions for sexual minority youth: A scoping review
Authors: Smith Ariel U. , Singer Randi , Jann Janna , Matthews Alicia (Phoenix) , Crooks Natasha 
Published: July 2022

Abstract
Background. Sexual minority youth (SMY) are disproportionately impacted by teen dating violence (TDV). However, current interventions do not address the distinct needs of SMY. Culturally safe and effective TDV prevention interventions targeted to SMY are needed. The purpose of this review is to (1) examine TDV interventions that are inclusive of SMY and (2) determine the effectiveness of the interventions in terms of both knowledge and behavioral changes.Methods. A scoping review was conducted and includes studies that met the following inclusion criteria: (1) evaluated a TDV prevention program,(2) included participants who identify as lesbian/gay, bisexual, unsure, or queer; (3) reported outcomes for SMY; and (4) were published in the English language. The Effective Public Health Project Quality Assessment Tool for Quantitative Studies and Garrard Matrix Method were employed to critically evaluate articles and synthesize findings.Results. A comprehensive search was conducted using five electronic databases that revealed 878 articles. Three articles were included in this review. Findings revealed that culturally targeted interventions improved dating violence knowledge and decreased the acceptance of sexual violence from pre-post intervention. However, current interventions have limited impact on behavioral outcomes among SMY. Moreover, quality assessments revealed that existing interventions were either weak or moderate, highlighting the need for additional research and culturally targeted TDV interventions.Discussion/Conclusion. Implications for future intervention development regarding measurement, recruiting and community partnership, institutional review board issues, improving behavioral outcomes, addressing unique risk factors, cultural targeting, intervention design, and methodological approaches are described.
Analgesic efficacy of local versus proximal nerve blocks afterhallux valgus surgery: A systematic review
Authors: Ravanbod Hamid 
Published: July 2022

Abstract
Background: Hallux valgus (HV) surgery is an orthopaedic procedure that commonly causes mild to moderate postoperative pain. Effective management of this pain has become an important element of modern hallux valgus surgical treatment. A local anaesthetic (LA) with an antinociceptive effect can control this pain. However, relatively few papers have evaluated this strategy in depth. The objective of the current systematic review was to address this demand by comparing the efficacy of proximal and local blocks in controlling postoperative pain following hallux valgus surgery.Main text: Ovid-MEDLINE, Cochrane Central, PubMed, Web of Science (WOS), Scopus, and Embase were searched from their inceptions through December 29, 2021. Observational and clinical trial publications in peer-reviewed English-language journals with a sample size of at least 20 were included. The trials involved adults over 18 who could describe their discomfort and had a bunionectomy. The included studies were evaluated using the Cochrane risk of bias 2 method. Descriptive analysis synthesised the results.Among the 439 articles identified, five studies compromising 459 participants were included. Ankle blocks were superior to control in two studies (P = 0.001, P < 0.001) and superior to local blocks in one study (P < 0.001). Additionally, one study showed that popliteal and ankle blocks administered with lidocaine or levobupivacaine were equivalent (P = 0.123 and P = 0.055, respectively). However, one of these five included studies indicated that ankle blocks were not effective (P = 0.123) in reducing postoperative pain.Conclusions: The key findings presented herein suggest that regional blocks effectively reduce postoperative pain and that an ankle block has more supportive evidence for its effectiveness. However, an adequate assessment of the effectiveness of various administrative routes was challenging due to the lack of reliable evidence. This needs to be addressed in future studies.Trial registration: PROSPERO registration: CRD42022307974