bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smart decision for device selection in D2D‐assisted multi‐path video transmission network
Authors: Zhao Xuan , Liu Bowen , Jiang Xutong , Tang Wenda , Dou Wanchun 
Published: June 2022

AbstractWatching the live video on a bus/train/tram has become an important pattern for people to enjoy their travel time. Due to the complex environment changes and obstacles caused by the rapid movement, the network state of the user device is often unstable. A large number of interruptions and resolution reductions seriously affect the user's watching experience. Through direct transmission between devices, Device‐to‐Device (D2D) can effectively improve video quality. Accurate decision for helper device selection is the key to optimize video streaming services based on D2D technology. However, the existing methods through D2D rarely consider the states and the intention of the helper devices when selecting cooperative devices, such as the watching status, the state of charge, the state of cache, and the connection quality. This is highly probable to reduce the efficiency of D2D transmission and the cooperation enthusiasm of helper devices. In addition, the existing methods seldom consider the multiple network interfaces in the device. In view of these challenges, we propose a dynamic smart decision method for device selection in D2D‐assisted multi‐path video transmission network (named DS‐DAMP). Specifically, this method takes the current states and the resource constraints into consideration to select the appropriate helper devices for video cooperative transmission, so as to improve the cooperation satisfaction of helper devices and optimize the video quality of the requesting device. Besides, we make full use of multiple network interfaces to realize multi‐path parallel transmission between devices. A large number of experiments have proved the good performance of our method in terms of video quality and network utility.
Incorporation of high‐altitude environmental effects in the linear elastic fracture mechanics‐based modeling of aluminum alloy 7075
Authors: Brown Luke B. , Dorman Sarah Galyon , Burns James T. 
Published: June 2022

AbstractAirframe structural components experience coupled load–environment spectra that are currently not captured in traditional damage‐tolerant management approaches. The effect of incorporating fatigue crack growth kinetics relevant to high‐altitude flight environments into LEFM‐based predictions of fatigue progression for aluminum alloy 7075‐T651 was quantitatively assessed for a variety of load–environment spectra using AFGROW. The results of this study demonstrated that in all conditions, the incorporation of high‐altitude‐relevant growth kinetics enhanced the fatigue life predictions. However, the magnitude of the impact on the overall life is dependent upon the subtleties of the coupled load–environment spectrum, despite the fact that environmental effects are most potent in the near‐threshold regime of the da/dN versus ΔK relationship. The potential impact to the structural integrity management community is discussed, and remaining challenges and opportunities are identified.
Correlation between the intensity of Helicobacter pylori colonization and severity of gastritis: Results of a prospective study
Authors: Souissi Salma , Makni Cyrine , Belhadj Ammar Leila , Bousnina Olfa , Kallel Lamia 
Published: June 2022

AbstractHelicobacter pylori infection is strongly associated with chronic gastritis and is probably the main course of chronic inflammation in the gastric mucosa. Gradually, H. pylori gastritis will result in gastric atrophy and intestinal metaplasia. Identifying the relationship between intensity of colonization and activity of gastritis helps the clinician in more effective treatment and post‐treatment follow‐ups. The aim of our work was to analyze the relationship between the density of H. pylori colonization of the gastric mucosa and the severity of histological parameters of gastritis (inflammation activity, gastric atrophy, and intestinal metaplasia). This was a prospective monocentric study conducted from January 2020 to December 2020, collecting patients naive to any anti‐H. pylori treatment and having a chronic H. pylori infection documented by histological examination. Epidemiological, endoscopic, and anathomopathological data were collected. Ninety‐seven patients with a mean age of 42.6 years [18–65 years] and a sex ratio of M/F = 0.64 were included. The density of H. pylori colonization was mild (+) in 43.3% of patients, moderate (++) in 47.4% of patients, and significant (+++) in 9.3% of patients. Nearly, ten per cent of patients had no gastritis, 33% had mild gastritis, 50.5% had moderate gastritis, and 6.2% had severe gastritis. Gastric atrophy and intestinal metaplasia were found in 44.3% and 10.3% of our population, respectively. Patients with mild H. pylori colonization rates had the highest level of mild activity (59.5%). There was a statistically significant association between the severity of H. pylori infection and gastritis activity (p < .001). Gastric atrophy was significantly associated with the intensity of H. pylori colonization (p = .049). No significant relationship was found between the intensity of colonization and metaplasia (p = .08). Our study shows that there is a statistically significant association between the density of H. pylori and histopathological findings including gastritis activity and intestinal atrophy.
Carbon‐ion radiotherapy for urological cancers
Authors: Ishikawa Hitoshi , Hiroshima Yuichi , Kanematsu Nobuyuki , Inaniwa Taku , Shirai Toshiyuki , Imai Reiko , Suzuki Hiroyoshi , Akakura Koichiro , Wakatsuki Masaru , Ichikawa Tomohiko , Tsuji Hiroshi 
Published: June 2022

AbstractCarbon‐ions are charged particles with a high linear energy transfer, and therefore, they make a better dose distribution with greater biological effects on the tumors compared with photons and protons. Since prostate cancer, renal cell carcinoma, and retroperitoneal sarcomas such as liposarcoma and leiomyosarcoma are known to be radioresistant tumors, carbon‐ion radiotherapy, which provides the advantageous radiobiological properties such as an increasing relative biological effectiveness toward the Bragg peak, a reduced oxygen enhancement ratio, and a reduced dependence on fractionation and cell‐cycle stage, has been tested for these urological tumors at the National Institute for Radiological Sciences since 1994. To promote carbon‐ion radiotherapy as a standard cancer therapy, the Japan Carbon‐ion Radiation Oncology Study Group was established in 2015 to create a registry of all treated patients and conduct multi‐institutional prospective studies in cooperation with all the Japanese institutes. Based on accumulating evidence of the efficacy and feasibility of carbon‐ion therapy for prostate cancer and retroperitoneal sarcoma, it is now covered by the Japanese health insurance system. On the other hand, carbon‐ion radiotherapy for renal cell cancer is not still covered by the insurance system, although the two previous studies showed the efficacy. In this review, we introduce the characteristics, clinical outcomes, and perspectives of carbon‐ion radiotherapy and our efforts to disseminate the use of this new technology worldwide.
Community mental health interventions for people with major depressive disorder: A scoping review
Authors: Tan Ronel Xian Rong , Goh Yong Shian 
Published: June 2022

AbstractPeople with major depressive disorder continue to be marred by chronically pernicious yet preventable outcomes in the biopsychosocial aspects. With the reallocation of healthcare resources towards the fight against the coronavirus 2019 pandemic, much emphasis has been placed on existing community mental health interventions to ameliorate the disruption of mental health services. Moreover, the recent propulsion of community mental health services by the World Health Organization Mental Health Action Plan 2013–2030 ignited the need to bolster existing community interventions by providing comprehensive, responsive and integrated mental healthcare. The enhanced emphasis on mental healthcare in the community and the heightened demands of people with major depressive disorder underscores the need to explore the current state of community mental health interventions. This scoping review examined 51 primary studies published from year 2010 to 2020 using Arskey & O′Malley's five‐stage framework and provided an overview of the impact of existing community mental health interventions for people with major depressive disorder. Findings using thematic analysis have recommended the adoption of person‐centred community mental healthcare via the biopsychosocial approach for people with major depressive disorder. Enablers of community mental health interventions were driven by culturally appropriate care and augmented by technology‐driven modalities. Challenges and gaps of community mental health interventions include the perpetuation of stigma and misconception, complex demands of persons with major depressive disorder and lack of holistic and long‐term outcomes. Given the impact of major depressive disorder on the various biopsychosocial aspects, it is envisioned that our insights into the enablers and barriers of community mental health interventions will guide prospective interdisciplinary and nurse‐led interventions in holistically improving the care of persons with major depressive disorder in the community settings.
Prediction of atrial fibrillation in patients with hypertension: A comprehensive comparison of office and ambulatory blood pressure measurements
Authors: Huang Pin‐Hsiang , Huang Chin‐Chou , Lin Shing‐Jong , Chen Jaw‐Wen 
Published: June 2022

AbstractHypertension is associated with the development of atrial fibrillation (AF). Evidence has shown that reverse dipping pattern, an abnormal increase of night‐time blood pressure (BP) comparing to daytime BP, is associated with cardiovascular events. However, the relationship between diurnal changes in BP and AF has not been sufficiently explored. This paper aims to cross‐sectionally explore the relationship between AF and ambulatory BP parameters, especially reverse dippers to the others, and further longitudinally analyze how BP patterns are associated to the risk of developing new‐onset AF. Between February 2012 and March 2021, five out of 412 patients were identified of AF at baseline; four were reverse dippers (3.7%) and one was from the others (.3%). Cross‐sectionally, the multivariate logistic regression analysis showed that reverse dippers were significantly more likely to have AF (odds ratio: 12.39,p = .030). After excluding patients with baseline AF, during the mean follow‐up of 4.6 ± 3.0 years, seven patients developed AF. Longitudinally, the multivariate Cox regression analysis revealed that 24‐h systolic BP (hazard ratio per 10 mmHg: 2.12,p = .015), night‐time systolic BP (hazard ratio per 10 mmHg: 2.27,p = .002), and presentation of reverse dipping (hazard ratio: 5.25,p = .042) were independently associated with new‐onset AF. None of the office BP measurements were associated with new‐onset AF. While ambulatory BP measurements were better predictors for the incidence of AF, careful management is necessary for reverse dippers as they are at high risk of developing AF.
Facial erythema in patients with atopic dermatitis treated with Dupilumab – a descriptive study of morphology and Aetiology
Authors: Ahn J. , Lee D.H. , Na C.H. , Shim D.H. , Choi Y.S. , Jung H.J. , Simpson E.L. 
Published: June 2022

AbstractBackgroundThe development of dermatitis on face and neck, which was not described in phase 3 clinical trials, has been reported in the literature in patients treated with dupilumab. Little is known regarding the causes or defining features of the facial dermatitis.ObjectivesWe conducted surveys of consecutive patients with AD on dupilumab to describe its clinical features, morphology and aetiology.MethodsA multi‐centre prospective cohort study was conducted from 1 January 2020, to 31 December 31 2020. A total of 162 patients under dupilumab treatment were asked to complete a questionnaire and patients were evaluated by dermatologists.ResultsOf all 162 patients, 137 (84.6%) patients reported pre‐existing facial dermatitis prior to dupilumab therapy. One hundred and twenty‐one (88.3%) patients with pre‐existing facial dermatitis reported improvement of their facial dermatitis with dupilumab therapy, nine (6.6%) patients reported no change after the treatment and seven (4.3%) patients of them got worse after the treatment (exacerbation group). Of 25 patients who reported no pre‐existing active facial dermatitis, six (24%) patients reported new‐onset facial erythema after the starting dupilumab therapy (new‐onset group). A large proportion of the patients in both the exacerbation (86%) and new‐onset groups (67%) had a history of facial TCS use. Both groups showed similar clinical manifestations and distribution with few differences.ConclusionsThe vast majority of patients treated with dupilumab in academic institutions from Korea and the United States experienced improvement in their facial dermatitis with dupilumab therapy. A small proportion of patients had new onset and exacerbation. Although the mechanisms of this adverse event remain unclear, steroid withdrawal should be considered as a diagnosis of the erythema in some patients.
Secukinumab demonstrated sustained retention, effectiveness and safety in a real‐world setting in patients with moderate‐to‐severe plaque psoriasis: long‐term results from an interim analysis of the SERENA study
Authors: Augustin M. , Sator P.G. , von Kiedrowski R. , Conrad C. , Rigopoulos D. , Romanelli M. , Ghislain P.‐D. , Torres T. , Ioannides D. , Aassi M. , Schulz B. , Jagiello P. ,   SERENA study group
Published: June 2022

AbstractBackgroundRandomized controlled trials of secukinumab have shown sustained efficacy and a favourable safety profile in multiple manifestations of psoriatic disease.ObjectivesTo assess the long‐term, real‐world retention, effectiveness and safety of secukinumab in routine clinical practice for the treatment of moderate‐to‐severe plaque‐type psoriasis (PsO).MethodsSERENA (CAIN457A3403) is a large, ongoing, longitudinal, observational study conducted at 438 sites and 19 countries for an expected duration of up to 5 years in adult patients with moderate‐to‐severe PsO, psoriatic arthritis and ankylosing spondylitis. Patients received ≥16 weeks of secukinumab treatment before enrolment. This interim analysis presents data from PsO patients, who were enrolled in the study between October‐2016 and October‐2018 and were observed for ≥2 years.ResultsIn total, 1756 patients (67.3% male) with a mean age of 48.4 years and body mass index of 28.8 kg/m2 were included in the analysis. The secukinumab treatment retention rates after 1, 2 and 3 years in the study were 88.0%, 76.4% and 60.5%, respectively. Of the 648 patients who discontinued the study, the most common reasons included lack of efficacy (42.6%), adverse event (17.4%), physician decision (12.2%) and subject decision (11.6%). Mean ± SD absolute PASI was 21.0 ± 13.0 at the start of treatment (n = 1,564). At baseline, the mean ± SD PASI score reduced to 2.6 ± 4.8 and remained low at Year 1 (2.3 ± 4.3), Year 2 (1.9 ± 3.6) and Year 3 (1.9 ± 3.5). The safety profile of secukinumab during the SERENA study was consistent with its known safety profile, with no new safety signals reported. Particularly, low rates of inflammatory bowel disease (0.3%; Incidence Rate [IR]:0.15), candida infections (3.1%; IR:1.43) and MACE (0.9%; IR:0.37) were observed.ConclusionsSecukinumab showed high treatment persistence, sustained effectiveness and a favourable safety profile up to 3 years of follow‐up in the real‐world population of PsO patients observed in SERENA.
Tilapia Lake Virus (TiLV) from Vietnam is genetically distantly related to TiLV strains from other countries
Authors: Tran Triet Hanh , Nguyen Vy Thuy Hoang , Bui Hieu Chi Nguyen , Tran Yen Binh Thi , Tran Huong Thanh Thi , Le Thao Thu Thi , Vu Huong Thanh Thi , Ngo Thao Phuong Huynh 
Published: June 2022

AbstractTilapia Lake Virus (TiLV) is reported as a threat to tilapia aquaculture in 16 countries on four continents with outbreaks causing up to 90% mortality. This research is one of the first studies on TiLVs from Vietnam. We propagated successfully one TiLV isolate HB196‐VN‐2020 from a diseased tilapia sample using an E‐11 cell line and evaluated its virulence in two different weights of red hybrid tilapia and three serial 10‐fold diluted viral titers. Smaller fish (4.5 ± 1.98 g) were proved to be more susceptible to TiLV infection at the viral titre of 9.1 × 105 TCID50 fish−1 than larger fish (20.8 ± 7.5 g) with the mortalities of 92.5% and 12.5%, respectively. Reassortant detection analysis revealed seven potential reassortment events among 23 TiLV genomes, indicating the mixed infection of multiple TiLV isolates at the farms and the fish movement among different regions. Seven maximum likelihood phylogenetic trees based on the individual segments or the concatenated coding regions of some segments showed the genetically distant relationship of the Southern Vietnamese isolate RIA2‐VN‐2019 with the 21 reference isolates, and suggest the different origins of two Vietnamese TiLV isolates (RIA2‐VN‐2019 and HB196‐VN‐2020). However, additional sequences from various sampling locations and times are required to better understand the impacts of genetic diversity and reassortments on the evolution, migration and natural selection of TiLVs in Vietnam and other countries.
Bored of the rings: Methodological and analytic approaches to operationalizing Bronfenbrenner's PPCT model in research practice
Authors: Navarro Jessica L. , Stephens Christina , Rodrigues Blenda C. , Walker Indya A. , Cook Olivia , O'Toole Leah , Hayes Noírín , Tudge Jonathan R. H. 
Published: June 2022

AbstractBronfenbrenner's ecological (and later bioecological) theory has been a mainstay in the theoretical wheelhouse of developmental and family sciences since its inception in the 1970s. However, few studies accurately operationalize Bronfenbrenner's process‐person‐context‐time (PPCT) research model. The aim of this paper is to provide a practical guide to the design, implementation, and analysis of PPCT research studies. Using recent qualitative and quantitative publications from developmental and family science journals, we illustrate how his theory can be operationalized simply and effectively in 21st‐century research. The eight studies, three qualitative and five quantitative, feature participants from Chile, China, South Africa, Turkey, and the United States.
Temporomandibular disorders, bite force and osseous changes of the temporomandibular joints in patients with hypermobile Ehlers‐Danlos syndrome compared to a healthy control group
Authors: Bech Karen , Fogh Frederikke Maria , Lauridsen Eva Fejerskov , Sonnesen Liselotte 
Published: June 2022

AbstractBackgroundEhlers‐Danlos syndrome (EDS) is a hereditary disorder that affects the connective tissue and collagen structures in the body characterised by joint hypermobility, skin hyperextensibility and tissue fragility.ObjectiveThe aim was to investigate temporomandibular disorders (TMD), bite force, teeth in occlusal contact and osseous changes of the temporomandibular joints (TMJs) in 26 patients with hypermobile EDS (hEDS), differentiated by a genetic test, compared to 39 healthy controls.MethodsClinical examination according to Diagnostic Criteria for Temporomandibular Disorders (DC/TMD), radiological examinations of the TMJs by cone‐beam‐computed tomographic (CBCT) scans, registration of bite force and teeth in occlusal contact was performed. Statistical analyses included Fisher's Exact Test, multiple logistic and linear regression models adjusted for age, gender and Body Mass Index (BMI).ResultsSingle symptoms and signs of TMD occurred significantly more often in hEDS (p = .002;p = .001;p = .003;p = <.0001;p = .012) and maximum mouth opening was significantly smaller in hEDS compared to controls (p = <.0001). The DC/TMD diagnosis myalgia, myofascial pain with referral, arthralgia, headache attributed to TMD, disc displacement disorders and degenerative joint disease occurred significantly more often in hEDS compared to controls (p = .000;p = .008;p = .003;p = .000;p = <.0001;p = .010, respectively). No significant differences were found in bite force and in teeth in occlusal contact between the groups (p > .05). On CBCT of the TMJs, subcortical sclerosis occurred significantly more often in hEDS compared to controls (p = .005).ConclusionSymptoms and signs of TMD and osseous changes of the TMJs occurred significantly more often in hEDS. Bite force and teeth in occlusal contact were comparable to controls.
High‐Definition Transcranial Direct Current Stimulation Over the Left Frontopolar Cortex Promotes Analogical Reasoning
Authors: Lundie Michael , Dasara Harshith , Beeghly Christopher , Kazmi Ali , Krawczyk Daniel 
Published: June 2022

ABSTRACTThe objective of this study was to measure the contribution of the left frontopolar cortex (FPC) to analogical reasoning. Our measure of analogical reasoning derives from performance on the radiation problem, a creative problem‐solving task first used in Gestalt psychology (Duncker, 1945). Success on this task is as low as 10 % without the presentation of explicit cues that guide inference toward the solution (Gick & Holyoak, 1980). We assessed whether high‐definition transcranial direct current stimulation of the left FPC would promote the analogical transfer of the radiation problem. We found that anodal stimulation primed analogical transfer and led to improved task performance compared to the cathode and sham control groups. Results from this study offer evidence favoring the hypothesis that stimulating the left FPC facilitates analogical problem‐solving.
Oral carcinoma cuniculatum, the great mimicker: Report of a challenging case and literature review
Authors: Vieira Gustavo de Souza , Câmara Priscilla Rodrigues , Rozza‐de‐Menezes Rafaela Elvira , Dias Eliane Pedra , Cunha Karin Soares 
Published: June 2022

AbstractOral carcinoma cuniculatum (OCC) is a rare and locally invasive well‐differentiated variant of squamous cell carcinoma. To date, 74 cases affecting the oral cavity were reported in English‐language literature. We report a case of maxillary OCC in a 71‐year‐old woman and review the demographic, etiological, clinicopathological, therapeutic and prognostic features of the OCC cases published in the English literature. From the 75 cases evaluated, there was no predilection for sex, and the highest incidence was between the seventh and tenth decades of life. Use of alcohol (17.3%), tobacco (29.3%), both (6.7%), and betel chewing (5.3%) were related in some cases. The clinical presentation was variable, and the gingiva and mandibular alveolar ridge were the most affected sites (50.7%). Inconclusive result or misdiagnosis in the initial histopathological examination was reported in more than 40% of cases, which required deeper or more representative biopsies for the definitive diagnosis. Radical surgery was the treatment of choice for 88.0% of cases. Overall, 10.7% of cases had cervical lymph node metastasis and 17.3% had recurrence after initial treatment, with only one death (1.3% of the cases). In conclusion, the wide variety of clinical presentations, lack of cytological atypia in most cases and need for deep incisional biopsies make the diagnosis of OCC challenging. Radical surgery is the main therapeutic modality and local recurrence after initial treatment occurs in less than 20% of cases. Although locally aggressive, regional and distant metastases are rare and the prognosis is good.