bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Tolerability of Ziprasidone Use in Children and Adolescents, a Systemic Review and Meta Analysis
Authors: Wadhwa A. , Sareen A. , Soeung C. , Penuelas-Calvo I. 
Published: September 2022

IntroductionZiprasidone is an atypical antipsychotic that has demonstrated efficacy for the treatment of bipolar disorder and schizophrenia. There is some preliminary evidence for Ziprasidone use in children and adolescents with several open label studies and some randomized control trials, therefore it is advantageous to understand where Ziprasidone lies in the treatment algorithm of children and adolescents.ObjectivesThe aim of our study is to examine the efficacy and tolerability of Ziprasidone in children and adolescents.MethodsWe conducted a literature search consisting of open label or randomized control trials (RCT) that report on Ziprasidone use in children on the PubMed database. We found 13 studies (11 open label and 2 RCT) that met our inclusion criteria. Our outcome measures included efficacy measures such as BPRS, YMRS, CGI-S and adverse effects such as weight gain, increase in BMI, QTc prolongation, sedation, dizziness and EPS.ResultsData from thirteen studies was meta-analyzed (Total n= 560, mean age=13.16 years, male= 70.35% that reported the use of Ziprasidone in children and adolescents. We found that Ziprasidone was efficacious in children and adolescents in measures of BPRS (-13.493, p<0.05), YMRS (-14.225, p<0.05), CGI-S (-1.430, p<0.05). In measures of adverse effects, Ziprasidone was not found to cause any significant weight gain (0.164, p>0.05) or change in BMI (-0.159, p>0.05). QTc prolongation was found to be significant (13.122, p<0.05).ConclusionsZiprasidone is an efficacious in children and adolescent population. It does not cause significant weight gain, however QTc prolongation and sedation were found to be the most significant side effects .DisclosureNo significant relationships.
The influence of family on health anxiety in frequently ill adolescents
Authors: Shishkova I. , Pervichko E. 
Published: September 2022

IntroductionAdolescents (especially frequently ill) from families where parents show high concern for their health, often themselves make complaints about their health status that do not receive medical confirmation (Kovalenko, 1998; Dielman et al., 1991). A study by T. Dillman and colleagues (1991) revealed a direct link between the perception of the disease in parents and children – the more seriously the parent perceives the child’s condition, the more seriously the child treats it, and the more complaints he has.ObjectivesTo study the influence of family on health anxiety in frequently ill adolescents.MethodsThe sample: 98 adolescents (mean age 16.1±0.9), 84 their parents (mean age 44.5±5.0). We used: “Short Health Anxiety Inventory” (SHAI; Salkovskis et al., 2002), The “Research on health-saving activities” (RHSA) questionnaire (Yakovleva, 2014), Questionnaire “Index of attitude toward health” (Deryabo, Yasvin, 1999).ResultsThe results of multiple regression analysis showed that health anxiety in adolescents is determined by the following parent’s features: goal-setting in the field of health-preserving activity (-0.661, p=0.036), standards of health (0.518, p=0.028), self-efficacy in the field of health-preserving activity (0.892, p=0.010), cognitive scale of attitude toward health (0.586, p=0.032) and scale of actions (0.059, p=0.002). It is also determined by parents’ vigilance to bodily sensations (0.815, p=0.000).ConclusionsHealth anxiety in adolescents is influenced by both cognitive, motivational and behavioral components of the attitude toward health of their parents, and also sensory (negative physical sensations and symptoms in parents form anxiety about health of their children). Research is supported by the Russian Science Foundation, project No. 21-18-00624.DisclosureResearch is supported by the Russian Science Foundation, project No. 21-18-00624.
Psychotropic drug use among children and adolescents in the Nordic countries - A systematic literature review
Authors: Ollerup D. , Elkrog S. , Stoltz-Andersen M. , Stubmark H. , Rasmussen L. , Wesselhoeft R. 
Published: September 2022

IntroductionThe Nordic countries have similar health care and welfare systems, and rather homogenous populations. Therefore, it is reasonable to expect similar use of psychotropic drugs. However, recent studies show marked differences in a range of psychotropic drug classes among children and adolescents in Sweden, Norway, and Denmark.ObjectivesTo review the literature regarding psychotropic drug use among children and adolescents in the Nordic countries.MethodsWe performed a critical systematic literature review according to PRISMA guidelines and registered the study protocol at PROSPERO. Three scientific databases were used: PsycINFO, EMBASE and PubMed. Inclusion criteria were: 1) Age: 3-19 years, 2) Country: Denmark, including Faroe Islands and Greenland, Sweden, Norway, Finland, including Aland, and Iceland, 3) Drug of interest: Psychotropics, including Antidepressants, ADHD medication, antipsychotics, hypnotics, anxiolytics, 4) Population based study sample, 5) Observational study design, 6) Original data, 7) English language, 8) Publication date: 2010-2021. The review process was performed by four reviewers in three steps: 1) title/abstract screening, 2) full text screening, and 3) data extraction, including risk of bias assessment. Before study initiation, acceptable interrater reliability was ensured by pilot tests.ResultsThe literature search was conducted October 6th, 2021. The PsycINFO database gave 285 hits, EMBASE 1190 hits and PubMed 2185 hits. In total, the literature search gave 3660 hits, of which 294 were duplicates, leaving us with 3366 references. The first screening phase is in process and results will be presented at the EPA conference.ConclusionsThe results of the systematic review will be interpreted and discussed.DisclosureNo significant relationships.
Emotional Well-Being of Parents Undergoing Family Therapy in a Children’s Psychiatric Clinic
Authors: Dovbysh D. , Bebchuk M. , Kopytina I. , Rodionova A. , Maruk I. , Balyakina I. 
Published: September 2022

IntroductionParents today can be important members of a multi-professional team, helping children with mental illness. The well-being of the parents is an important factor in successfully helping the child and willingness to cooperate with specialists.ObjectivesTo investigate the experiences of parents undergoing family psychotherapy on an outpatient basis and during a child’s hospitalization.Methods
86 parents who applied for family therapy on an outpatient basis and 80 parents (main group) of hospitalized children took part in the study. Participants were offered the following questionnaires: Beck Hopelessness Scale, modified scales of the Dembo-Rubinstein, GAD-7, PHQ-9, Quality of Life Enjoyment and Satisfaction Questionnaire. The study was conducted from 04/01/2021 to 04/14/2021.ResultsThe main group significantly differs from the outpatient group in the following parameters (according to the t-test): the level of depression (M=18,34 and M=11,61 respectively) and anxiety (M=12,07 and M=7,96 respectively), the quality of life in the sphere of emotional well-being, social sphere, activity and free time, as well as the happiness self-assessment scales. The results on the scales of depression and hopelessness are inversely significantly associated with the willingness of parents to participate in family psychotherapy (r=-0,74, p=0,01) visit the child (r=-0,58, p=0,05), and regularly contact a doctor (r=-0,61, p=0,05).ConclusionsDepending on the well-being of family members and the tasks facing the family, family assistance may differ depending on the stage of treatment of the child.DisclosureNo significant relationships.
Hair cortisol and self-perceived stress in adolescents with functional somatic disorders – a comparison with general population data
Authors: Nyengaard R. , Kallesøe K. , Rimvall M. , Ørnbøl E. , Olsen E.M. , Wyller V. , Rask C. 
Published: September 2022

IntroductionFunctional somatic disorders (FSDs) are characterized by persistent and disabling physical symptoms that cannot be attributed to well-defined somatic disorders. In adolescents, the prevalence is around 4-10%. Evidence from adult populations suggests that cortisol plays a role in the development and perpetuation of FSDs, but little is known regarding adolescents. As cortisol accumulates in hair over time, hair cortisol concentration (HCC) is a promising new biomarker for long-term physiological stress. Moreover, adult studies have found associations between HCC levels and self-perceived stress.Objectives
To compare HCC levels between adolescents with severe FSDs and adolescents from the general population. Furthermore, to investigate the association between HCC and self-perceived stress.MethodsThe data are retrieved from two projects: the AHEAD trial, including 91 15-19-year-old adolescents diagnosed with a severe FSD, and the Copenhagen Child Cohort 2000 (CCC2000), including data on 1455 16-17-year-old adolescents. Hair samples were collected for HCC analysis, and web-based questionnaires were used to asses self-perceived stress. Functional somatic symptoms were assessed with the Bodily Distress Syndrome (BDS) checklist.ResultsThe data have been collected and will be analysed and presented at the congress.ConclusionsThis study can contribute with knowledge about the potential role of cortisol in FSDs in adolescents, and whether self-perceived stress can be used as a marker for physiological stress measured by HCC. Treatments for adolescents with FSDs still need to be improved. The current study may help to understand whether future treatment strategies should include a greater focus on stress management.DisclosureNo significant relationships.
Parent Child Interaction Training (PCIT) in Zurich, Switzerland - Experiences and Results of the first two years
Authors: Zulauf-Logoz M. , Mailaender Zelger V. 
Published: September 2022

IntroductionParent Child Interaction Training PCIT (Zisser & Eyberg, 2010; Briegel, 2016) is an evidence-based treatment of oppositional defiant disorder in preschool children. However, it is implemented in few institutions in Europe. The advantage of PCIT is the involvement of both child and parents with direct coaching of the parents.ObjectivesWe will give an overview of 20 treatment courses we have conducted since the introduction of PCIT at the Zurich University Hospital for Child and Adolescent Psychiatry. First, a descriptive analysis of our sample will be conducted. The influence of sample characteristics and intensity of training on the reduction of behavioral problems will be analyzed.MethodsParents attend the training for at least 6 months with regular sessions. The transfer into everyday life is achieved by daily homework. We use the Eyberg Child Problem Behavior Inventory as pre-post measurements. The ECBI is filled out by the parents before each session and also enables a progress analysis.ResultsThree times more boys participated than girls. Problem behavior was significantly reduced after the play training phase. There was also a significant overall pre-post effect. The effect seemed to be independent of the parental problem score before training and of the number of play-training sessions.ConclusionsParents and children clearly benefit from the play training. For the following cooperation training, the problem load experienced by the parents seems to be more relevant than the intensity of the child’s problem behavior as assessed by them. This is to be examined in the future.DisclosureNo significant relationships.
The association between transient childhood psychotic experiences and psychosocial outcomes in young adulthood: examining the role of mental disorder and attachment
Authors: Staines L. , Healy C. , Cotter D. , Kelleher I. , Cannon M. 
Published: September 2022

IntroductionPsychotic experiences (PE) occur most often in childhood, at the same age many mental disorders (MD) develop. There is growing evidence that those who report PE and MD show poorer health outcomes. If this occurs in psychosocial outcomes e.g. self-esteem, stress, mental distress, or social support, is under examined. Attachment anxiety and avoidance are the dimensions of attachment, which is hypothesized to develop in infancy as a mechanism for interpersonal relationships in times of need.ObjectivesTo examine the role of transient childhood PE in adult psychosocial outcomes, in those with and without MD. Additionally, to examine if the dimensions of attachment attenuate this model.MethodsOne hundred and three participants attended baseline (age 11 – 13) and 10-year follow-up. PE and MD were collected using the Schedule for Affective Disorders and Schizophrenia for School-aged Children, Present & Lifetime Version. Attachment and outcomes were collected using self-report measures. Analysis compared those with PE, MD and PE and MD, to healthy controls.ResultsPE in childhood was associated with lower self-esteem and lower perceived social support from friends. Lower self-esteem in adulthood was more pronounced in those reporting PE and MD, and was additionally associated with stress in relationships, daily life, and mental distress. Childhood MD without PE was not significantly associated with any psychosocial outcomes. Attachment dimensions significantly attenuated the relationship between PE and self-esteem.ConclusionsThis paper illustrates the significant association of childhood PE on adult outcomes, independent of the effect of co-occurring MD, and demonstrate attachment dimensions role in this model.DisclosureNo significant relationships.
Neurofibromatosis type 1 comorbid with attention deficit and hyperactivity disorder. Case report
Authors: Del Sol Calderón P. , Paricio Del Castillo R. , Mallol Castaño L. , Izquierdo De La Puente A. , Garcia Moreno M. 
Published: September 2022

IntroductionA 9-year-old girl under pediatric follow-up since the age of 4 years after diagnosis of neurofibromatosis type 1ObjectivesTo present a case of neurofibromatosis and ADHD comorbidity to raise awareness of the importance of screening for neurodevelopmental disorders.MethodsCase report and literature reviewResultsThe patient had an adequate control and follow-up of the disorder with periodic check-ups and magnetic resonance imaging during her follow-up. She was referred due to symptoms of inattention with failure to perform exams and impulsivity in interpersonal relationships, affecting her social functioning. In addition, the patient presented simple motor tics of eye contraction and shoulder elevation. The patient was diagnosed with attention deficit hyperactivity disorder together with tic disorder. She was treated with stimulant medication with worsening of tics and marked hyporexia. Therefore, medication with guanfacine was started up to 4 mg per day, adjusted by weight. With this dose there was a control of the tics, with improvement of the symptoms of inattention and impulsivity. In different spheres an improvement in their functionality was observed, with improvement in mood, self-esteem and academic performance.ConclusionsNeurofibromatosis type 1 is a rare monogenic disorder with a varied presentation (ophthalmologic, dermatologic and predisposition to tumor development). Patientshave been shown to present with symptoms of inattention and executive function impairment, along with other neurodevelopmental disorders such as autism spectrum disorders, learning disabilities or intellectual disability. The literature shows that up to 60% of them has ADHD criteria.DisclosureNo significant relationships.
Attitude Toward Disorder as Risk Factor for Psycho-Emotional Disturbances in Children with Dysphasia
Authors: Fedorova Y. , Burlakova N. 
Published: September 2022

IntroductionDysphasia is widespread among children. Awareness of speech difficulties and emotional attitude toward them may influence different aspects of mental activity. The issue is important for development assessment and discussion on potential risk factors causing other mental disorders.ObjectivesThe aim of the study was to analyze how children with dysphasia perceive their speech defect and how it influences their behaviour.Methods15 children with dysphasia aged 5 years (6 boys, 9 girls) participated in the study. The following methods were used: not included and included observation in a speech therapy group for 6 months, semi-structured interview with educators.ResultsObservation and interviews enabled to discover two groups featuring different attitudes. 1) The first group (n=12) included children who ignored their speech difficulties. Behavioral and speech activity was confident and spontaneous. Children demonstrated difficulties in planning and regulation of activity, low level of self-criticism. In failure situations, children demonstrated egocentrism, emotional rigidity and experienced difficulties in emotional regulation during assessment. 2) The second group (n=3) experienced high anxiety in communicative situations and estrangement caused by hypersensitivity to speech difficulties. Children preferred to use nonverbal communication and reduce speech initiative due to difficulties in verbal self-expression. Emotional specifics were characterized by recurrent ambivalence in the independent activity. Structured situations, such as assessment, actualized active self-control, which sometimes led to communicative difficulties and stupor.ConclusionsResults demonstrate various attitudes to speech difficulties in children with dysphasia. Behavioral, emotional and personal features are rich material for discussion on risks in mental development of children with speech disorders.DisclosureNo significant relationships.
Electroconvulsive therapy in children and adolescents: a case report
Authors: Mallol Castaño L. , Del Sol Calderón P. , Paricio Del Castillo R. 
Published: September 2022

IntroductionElectroconvulsive therapy is a proven treatment for mood and psychotic disorders in adult patients. It is estimated that in children and adolescents this type of therapy is underutilised despite the fact that the most recent studies have supported the success of ECT in these patients. A case is described of a 15-year-old male patient diagnosed with psychotic disorder who was previously treated with several antipsychotics, including clozapine, and finally treated with electroconvulsive therapy.ObjectivesReview of the clinical indications of electroconvulsive therapy in children and adolescents with psychotic or mood disorders through a clinical case of a patient admitted to a Psychiatric Short Stay UnitMethodsDetailed psychopathological description of the case as well as the treatments used (psychotropic drugs and electroconvulsive therapy).ResultsAfter the administration of electroconvulsive therapy, an improvement in both positive and negative psychotic symptomatology was observed, with a decrease in soliloquies and an improvement in affective flattening.ConclusionsElectroconvulsive therapy is an effective treatment in adolescent patients with psychotic and mood disorders, which should be considered as indicated as an effective treatment.DisclosureNo significant relationships.
Type 1 diabetes and anxiety in adolescence. A case report
Authors: Franco Soler A. , Cerame A. , Coucheiro Limeres P. 
Published: September 2022

Introduction
Type 1 diabetes (T1D) incidence is increasing around the world, being the third chronic medical condition in childhood. It is characterized by pancreatic β-cell loss which leads to insulin deficiency. Treatment includes insulin medication and lifestyle changes. Youngsters with T1D are at a high risk of psychological comorbidity (depression, anxiety, eating disorders), and especially anxiety symptoms have been correlated with worse diabetes control.ObjectivesOur purpose is to examine the impact of T1D in adolescence regarding a case report and literature review.MethodsWe present the case of a 14-year-old female with T1D onset and no psychiatric history. She is referred to our service three months after the T1D onset. Both her parents and the patient were anxious about the diagnostic implications and the treatment. The patient sometimes refused to follow insulin treatment and was angry and labile. Both family and individual assessment interviews were accomplished.ResultsRegarding our assessment and after coordination with endocrine service (doctor and nurse) we diagnosed an [F43.23] Adjustment Disorder (acute, with mixed anxiety and depressed mood). Following recent evidence Acceptance and Commitment Therapy and Family Therapy were the election treatment with good outcomes. The patient was released after 3 months of follow-up.Conclusions

T1D treatment entails lifestyle changes and self-control, which may be stressful and challenging for adolescents and their families, causing mental health problems. Since learning self-care and emotional coping strategies can improve both psychological well-being and glucose management, an interdisciplinary approach including psychological care, especially on the onset, can be crucial.DisclosureNo significant relationships.
Menke-Hennekam syndrome 1: A Case Report
Authors: Trusmei M. , Budisteanu M. 
Published: September 2022

IntroductionMenke-Hennekam syndrome (MHS) is a relatively new genetic condition characterized by intellectual disabilities, autistic behavior, auditory defects, recurrent upper respiratory tract infections, microcephaly and short stature. Facial characteristics include short palpebral fissures, telecanthus, depressed nasal bridge, short nose, anteverted nares, short columella, and long philtrum. The genetic defect is represented by missense variants of CREBBP gene, located on exons 30 or 31. There are only around 30 cases reported by now.ObjectivesThe aim of the paper is to report a new case of MHS.MethodsThe case is a 3-year-old boy admitted in our department for developmental delay. The clinical examination revealed dysmorphic features; severe speech delay, mild intellectual disability, autistic behaviour.The patient had a personal history of recurrent respiratory infections, visual defect and bilateral sensorineural hearing loss. Other investigations included EEG, abdominal echography, and cerebral MRI all were normal. The genetic studies included array CGH and WES.ResultsThe array CGH was normal. WES identified a pathogenic heterozygote variant c.5600G>A in the exon 31 of CREBBP gene, confirming MHS.ConclusionsOverall, the features of our patient are consistent with those reported in the previous reports, including developmental and speech delay, autistic behavior, dysmorphic features, recurrent upper way infections, sensorineural hearing loss, and visual defects. Other common features, such as growth delay and microcephaly were not present in our patient. Our case contributes to the clinical characterisation of the new syndrome. Funding: The research leading to these results has received funding from the EEA Grant 2014-2021, under the project contract No 6/2019.DisclosureNo significant relationships.