bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hazard Assessment of Debris-Flow Prone Watersheds in Cubatão, São Paulo State, Brazil
Authors: Veloso Vinicius Queiroz , Reis Fabio , Cabral Victor , Zaine José , Corrêa Claudia , Gramani Marcelo , Kuhn Caiubi 
Published: May 2022

Abstract
In Brazil, research related to the occurrence and prevention of debris flows is incipient when compared to the extent of the impacts caused by the phenomena. There is a need for more studies that consider their susceptibility and hazard, especially in areas that are environmentally and socioeconomically vulnerable. This study aims at assessing debris-flow hazard in the Rio das Pedras watershed, in Cubatão (São Paulo State, Brazil), based on a set of different physiographic parameters (geomorphological, morphometric, geological) and the application of empirical models. The hazard assessment was based on: (i) the evaluation of the history of events in the region; (ii) the identification of the geomorphic controlling factors; (iii) the estimation of the magnitude of a potential event and, (iv) the identification of the elements at hazard. The results show that a debris-flow event in Rio das Pedras would more severely impact the Anchieta Highway (SP-150), the gas pipeline GASAN, the oil pipeline OSSP, and the districts Pinhal do Miranda and Cota 95. The results showed the relevance of geomorphological and geological parameters in estimating the magnitude of debris runoff for defining the danger in watersheds susceptible to the occurrence of debris flows.
Prophyromonas gingivalis promotes the progression of oral squamous cell carcinoma by activating the neutrophil chemotaxis in the tumor microenvironment
Authors: Guo Zhichen , Jing Si-li , Jumatai Sakendeke , Gong Zhong-cheng 
Published: May 2022

Abstract
Background: We aimed to determine the significance of Porphyromonas gingivalis (P. gingivalis) in promoting tumour progression in the tumour microenvironment (TME) of oral squamous cell carcinoma (OSCC). Methods: The Gene Expression Omnibus (GEO) was used to screen out the differentially expressed genes from the two datasets of GEO138206 and GSE87539. Immunohistochemistry and immunofluorescence analysis of samples, cell biological behaviour experiments, and tumour-bearing animal experiments were used to verify the results in vivo and in vitro. The mechanism was revealed at the molecular level, and rescue experiments were carried out by using inhibitors and lentiviruses. Results: CXCL2 was selected by bioinformatics analysis and was found to be related to a poor prognosis in OSCC patients. Samples with P. gingivalis infection in the TME of OSCC had the strongest cell invasion and proliferation and the largest tumour volume in tumour-bearing animal experiments and exhibited JAK1/STAT3 signalling pathway activation and epithelial-mesenchymal transition (EMT). The expression of P. gingivalis, CXCL2 and TANs were independent risk factors for poor prognosis in OSCC patients. A CXCL2/CXCR2 signalling axis inhibitor significantly decreased the invasion and proliferation ability of cells and the tumour volume in mice. When lentivirus was used to block the CXCL2/CXCR2 signalling axis, the activity of the JAK1/STAT3 signalling pathway was decreased, and the phenotype of EMT was reversed. Conclusion: P. gingivalis promotes OSCC progression by recruiting TANs via activation of the CXCL2/CXCR2 axis in the TME of OSCC.
Phosphonium Modified Nanocellulose Membranes with High Permeate Flux and Antibacterial Property for Oily Wastewater Separation
Authors: Peng Kun , Wang Chenglong , Chang Chunyu , Peng Na 
Published: May 2022

Abstract
Nanocellulose membranes could efficiently separate oily wastewater because of their superhydrophilic and underwater superoleophobic property and nanoporous structure. However, the practical application and storage of nanocellulose membranes were limited by their low water permeation flux and easy corrosion by bacteria, respectively. Herein, nanocellulose membranes with high permeate flux and antibacterial property were fabricated by grafting tetrakis(hydroxymethyl) phosphonium chloride (THPC) onto the surface of tunicate cellulose nanofibers (TCNFs) via esterification reaction. The introduction of THPC groups with tetrahedral structure on the surface of TCNFs significantly improved the pore size and interlayer space of nanocellulose membranes, resulting in the increasing of water permeation flux. These THPC@TCNF membranes were superhydrophilic and underwater superoleophobic, which could effectively separate various oil/water nanoemulsion. Moreover, THPC@TCNF membranes possessed excellent durability, mechanical stability, and cycling performance. Due to the presence of positively charged phosphonium groups, THPC@TCNF membranes exhibited excellent antibacterial property against B. subtilis that is a typical Gram-positive bacterium presenting in oily wastewater. This works provided a facile method to endow nanocellulose membrane with high permeate flux and antibacterial property.
Improved efficiency of callus induction, bud differentiation, and p lant regeneration in radish (Raphanus sativus L.)
Authors: Li ChangMan , Gao Jian , Li WenBo , Fang Ping , Liu Yi , Wang ChuanYi , Chen Fa-Bo 
Published: May 2022

Abstract
Radish (Raphanus sativus L.), a biennial root vegetable crop belonging to the Brassicaceae family, is an economically important vegetable grown worldwide. Radish is a recalcitrant variety for embryogenic callus induction that does not result in an efficient genetic transformation system. In this study, an efficiency regeneration system of callus induction and bud differentiation in radish was established using cotyledons explants. Among the 13 types of explants (epicotyl, cotyledon leaves, cotyledons with petioles, petioles of cotyledons, euphylls, petioles of euphylls, ovaries, pericarps, immature embryos, mature embryos, stems, stems with buds, and terminal buds), cotyledon leaves had the highest induction rate (91.01%) and were the most suitable explant. In addition, the optimal conditions for callus induction was MS-1 medium supplemented with 0.2 mg/L 2,4-dichlorophenoxyacetic acid, 0.5 mg/L thidiazuron (TDZ), 0.2 mg/L α-naphthalene acetic acid (NAA), 4 mg/L 6-benzylaminopurine (6-BA), 0.1 mg/L kinetin, 8 g/L agar, and 3 g/L sugar, with a callus induction rate of 94.77%. Moreover, the best medium for shoot regeneration was MS-1 medium supplemented with 1 mg/L TDZ, 1 mg/L 6-BA, 8 g/L agar, and 3 g/L sugar, with a bud regeneration rate of 15.54%. The most suitable medium of rooting was 1/2 MS-1 medium fortified with 0.2 mg/L NAA, 0.2 mg/L 3-indolebutyric acid, 0.1% activated carbon, 8 g/L agar, and 3 g/L sugar, achieving a rooting ratio of 89.05% and transplanting survival rate survival ratio of 94.92%. This study lays a good foundation for future breeding and molecular studies of radishes.
AuthROS: A Secure and Convenient Framework for Data Sharing among Robot Operating Systems (ROS)
Authors: Zhang Shenhui , Tao Songjing , Li Xiulai , Wu Shuang , Tang Ming , Tang Zeping , Liang Zhixuan , Liu Bernie 
Published: May 2022

Abstract
Robot Operating System (ROS) has brought great potential for automation in all fields involved in production activities, which greatly improves productivity and simplifies operations that belonged to humans originally. However, ROS is highly dependent on communication but lacks secure data sharing mechanisms. Therefore, when it comes to multi-robots interaction scenarios, there are severe challenges in ensuring the safe and trustworthy exchange of specified confidential data among multi-robots. The reliability of data also needs to be considered carefully. This paper proposes a solution to this problem based on blockchain technology. We present a general secure and convenient authorization framework named AuthROS for ROS nodes with absolute security and high availability based on private Ethereum network and SM algorithms. This framework is capable of meeting the requirements for immutability and security of confidential data exchange in nodes of ROS of any size. An authority granting and identity identifying mechanism is proposed and integrated into the Ethereum smart contract to execute atomically to ensure the trustworthiness exchange of data and no third-party participation. At the same time, a key exchange based on SM2 and plaintext encryption mechanism based on SM4 is proposed to ensure the data transmission security. Furthermore, a data digest uploading scheme is adopted to improve the efficiency of querying and data uploading to the Ethereum network. Based on all of mechanisms mentioned above, AuthROS can play a role in the scenario where data transmitted among robots need to be recorded and maintain immobility. Experimental results demonstrated that AuthROS is equipped with excellent security, good time performance along with Nodes Forging resistance. We believe that AuthROS is the first secure data sharing framework for Robots loaded with ROS. We open sourced AuthROS at https://github.com/RobAI-Lab/ROS-Chain.
The expected environmental impact of the King Abdulaziz Public Transport Project on the level of air quality
Authors: Al-Asqa Amanah , Al-Muqari Mohammed Saad , Al-Turki Afnan Abdullah 
Published: May 2022

Abstract
This paper study King Abdulaziz Public Transport Project in Riyadh. Its expected impact on reducing air pollution and raising its quality level in 2030. Without a doubt, transportation is one of the basic pillars of sustainable development; nevertheless, it is one of the most important sources of air pollution. The main objectives of the study: identifying the current situation of air pollution in Riyadh, reviewing the efforts of the authority to improve the air quality, estimating the size of the population and expected daily trips in 2020 and 2030, and determining the project's expected effects on air quality. The result estimated the population of Riyadh is expected to reach about (7.8) million in 2020 and rise to about (10.4) million in 2030. As for the number of daily trips is expected to reach more than (9) million trips in 2020 and rise to more than (12) million trips in 2030. It is expected that the implementation of the KAPTP will start in 2022. Furthermore, it is expected that about 20% of daily trips will change after operating the project, and the alteration will increase to about 25% in 2030. Therefore, the project is expected to reduce air pollution by about 30% after operating the project, and then to about 40% in 2030. The study recommends preparing an extensive media plan to prepare the community, encourage it to use public transport, and study public transport tariffs and motivate public transport by imposing fees for using roads and parking lots.
Identification and In Vitro and In Vivo Validation of the Key Role of GSDME in Pyroptosis-Related Genes Signature in Hepatocellular Carcinoma
Authors: Chen Xinyi , Tu Jingyao , Wang Lu , Zhou Xiao , Yuan Xianglin 
Published: May 2022

Abstract
We used pyroptosis-related genes to establish a risk–score model for prognostic prediction of liver hepatocellular carcinoma (LIHC) patients. A total of 52 pyroptosis-associated genes were identified. Then, data for 374 LIHC patients and 50 normal individuals were acquired from the TCGA database. Through gene expression analyses, differentially expressed genes (DEGs) were determined. The 13 pyroptosis-related genes (PRGs) confirmed as potential prognostic factors through univariate Cox regression analysis were entered into Lasso and multivariate Cox regression to build a PRGs prognostic signature, containing four PRGs (BAK1, GSDME, NLRP6 and NOD2) determined as independent prognostic factors. mRNA levels were evaluated by qRT-PCR while overall survival (OS) rates were evaluated by the Kaplan-Meier method. Enrichment analyses were done to establish the mechanisms associated with differential survival status of LIHC patients from a tumor immunology perspective. Additionally, a risk score determined by the prognostic model could divide LIHC patients into low- and high-risk groups using median risk score as cut-off. A prognostic nomogram, derived from the prognostic model and integrating clinical characteristics of patients, was constructed. The prognostic function of the model was also validated using GEO, ICGC cohorts and online databases including Kaplan-Meier Plotter and GEPIA. Small interfering RNA-mediated knockdown of GSDME as well as lentivirus mediated GSDME knockdown were performed to validate that knockdown of GSDME markedly suppressed growth of HCC cells both in vivo and in vitro. Collectively, our study demonstrated a PRGs prognostic signature which had great clinical value in prognosis assessment.
Analysis of differentially expressed long noncoding RNAs in LPS-induced human HMC3 microglial cells
Authors: Baek Mina , Chai Jin Choul , Choi Hae In , Yoo Eunyoung , Binas Bert , Lee Young Seek , Jung Kyoung Hwa , Chai Young Gyu 
Published: May 2022

Abstract
Background: The human microglial HMC3 cell line assumes an inflammatory phenotype when challenged with lipopolysaccharide (LPS). Long noncoding RNAs (lncRNAs) are emerging as key modulators of immune system by regulating the expression of inflammatory genes. Here, we identified the differentially expressed long non-coding RNAs (DElncRNAs) and correlated DEmRNAs and explored their potential roles and interactions using bioinformatics tools such as gene ontology (GO), kyoto encyclopedia of genes and genomes (KEGG), and weighted gene co-expression network analysis (WGCNA).Results: We identified 5 DElncRNAs and 99 DEmRNAs including 4 novel DElncRNAs (AC083837.1, IRF1-AS1, LINC02605, and MIR3142HG) in microglia. The DElncRNAs with their correlated DEmRNAs fell into two network modules that both were enriched with inflammation-related RNAs. However, treatment with the anti-inflammatory agent JQ1, an inhibitor of the bromodomain and extra-terminal (BET) protein BRD4, neutralized the LPS effect in only one module, showing little or even enhancing effect on the other. Conclusions: These results provide insight into, and a resource for studying, the regulation of microglia-mediated neuro-inflammation and its potential therapy by small-molecule BET inhibitors.
The Comparison of Family Function and Related Factors in First-Child Infertile Women and Second-Child Infertile Women after “Two-Child” Policy in China
Authors: Qiu Tian , Tan Jianyu , Ma Zhi , Zhao Yong , Wang Wenling , Jiang Huimin , Wang Fengdi , Chen Yuelu , Han Ting-Li , Yang Yang , Wang Lianlian 
Published: May 2022

Abstract
Background: The rising prevalence of infertility rates worldwide has had a significant impact on individuals, couples, and families. This study examines how infertility affects family functions in China under the newly implemented two-child policy. We compared family function in first-child infertile (FI) and second-child infertile (SI) women.Methods: This study included 572 infertile women of childbearing age, composed of 337 first-child infertile women and 235 second-child infertile women in a reproductive medical center in Chongqing, China, between Feb 2016 and Dec 2018. The Family Assessment Device (FAD) and Family Cohesion And Adaptability Evaluation Scale II (FACES II) scores were used to assess family perception. The Patient Health Questionnaire-9 was used to assess depression (PHQ-9). Results: The demographic statistics of our sample showed the age of FI was 33.26±3.46, while the SI was 36.68±5.01. 46% of FI women are the only child, while 23.8% of SI women are the only child (P＜0.001). FI women had higher levels of education than SI women (P＜0.001). FI women made higher incomes than SI did (P＜0.001). The psychiatric diagnostics showed that 170(50.4%) of FI families and 157(66.8%) of SI families had a poor family function (P＜0.001). We found that infertility women with lower levels of education and family income are more likely to have an unhealthy family function (P＜0.05) based on the correlation analysis (P＜0.05). The total score of PHQ-9 is related to the family function (P＜0.05).Conclusions: The socio-demographical statistics show SI women have lower family monthly income and lower education levels than FI individuals. SI women obtained worse scores and more family dysfunction rates regarding family functioning. The study indicated that infertile families generally have higher risks in family functioning, family cohesion, and family adaptability. Counselors and psychologists can be deployed in infertility centers to screen people with family problem risks from the beginning and perform early interventions to improve family problems.
Paths to annihilation: Genetic and demographic consequences of range contraction patterns
Authors: Rogan Jordan E. , Parker Mickey Ray , Hancock Zachary B. , Earl Alexis D. , Buchholtz Erin K. , Chyn Kristina , Martina Jason , Fitzgerald Lee A. 
Published: May 2022

Abstract
Species range contractions both contribute to, and result from, biological annihilation, yet do not receive the same attention as extinctions. Range contractions can lead to marked impacts on populations but are usually characterized only by reduction in extent of range. For effective conservation, it is critical to recognize that not all range contractions are the same. We propose three distinct patterns of range contraction: shrinkage, amputation, and fragmentation. We tested the impact of these patterns on populations of a generalist species using forward-time simulations. All three patterns caused 86-88% reduction in population abundance and significantly increased average relatedness, with differing patterns in declines of nucleotide diversity (π) relative to the contraction pattern. The fragmentation pattern resulted in the strongest effects on post-contraction genetic diversity and structure. Defining and quantifying range contraction patterns and their consequences for Earth’s biodiversity would provide useful and necessary information to combat biological annihilation.
Primeval Aptian marine incursions in the interior of Northeastern Brazil following the Gondwana breakup
Authors: Fauth Gerson , Kern Henrique Parisi , Villegas-Martín Jorge , Mota Marcelo Augusto de Lira , Filho Marcos Antonio Batista dos Santos , Catharina Amanda Santa , Leandro Lilian Maia , Luft-Souza Fernanda , Strohschoen Oscar , Nauter-Alves Andressa , Tungo Edna de Jesus Francisco , Bruno Mauro Daniel Rodrigues , Ceolin Daiane , Baecker-Fauth Simone , Bom Marlone Heliara Hüning , Lima Francisco Henrique de Oliveira , Assine Mario Luis 
Published: May 2022

Abstract
This study reports a set of primeval marine incursions identified in the two drill cores (1PS-06-CE and 1PS-10-CE) recovering the Barbalha Formation, Araripe Basin, Brazil. Based on multi-proxy approach involving stratigraphy, microbiofacies, ichnofossils, and microfossils found in the Barbalha Formation, three short-lived marine incursions were identified, designated Araripe Marine Incursions (AMI). The AMI-1 and AMI-2, which occur within the shaly Batateira Beds (lower part of the Barbalha Formation), were identified through the occurrence of benthic foraminifera, calcareous nannofossils, dinocysts, and a mass mortality event of non-marine ostracods. The AMI-3 is recorded in the upper part of the Barbalha Formation and its identification was based on occurrence of ichnofossils and planktic foraminifers. The presence of planktic foraminifera genus Leupoldina suggests, for the first time in the basin, an early Aptian/early late Aptian age for the deposits and allows correlation of this unit with global foraminifera biozonation. Our findings have implications for the breakup of the Gondwana Supercontinent, as these incursions represent the earliest marine-derived flooding in the inland basins of Northeastern Brazil.
The typical Organic pollutants Survey and Health Risk Assessment Of the main Source Water In Huaihe River Basin
Authors: Gao Jijun , Liu Linghua , Liu Xiaoru , Wang Qiwen , Liu Laisheng , Lao Tianying 
Published: May 2022

Abstract
Background: Because of the rapid development of economy and explosion of city population, The Huaihe River basin was much more polluted among the seven largest basins in China, the organic pollutants could probably affect the drinking water safety of people in the Huaihe River basin. In this paper, the current state of knowledge on occurrence and health risk are presented and used to conduct health risks assessment of source water in the Huaihe River basin posed by Benzene homology, Chlorobenzene compounds, organophosphorous pesticides, and Nitrobenzene compounds, total 17 compounds.Result:The key findings from this review are that: (1) the concentrations of the 17 compounds in the fifty-one source water samples were all less than the standard limit values of Chinese surface water quality standard; (2) the benzene, toluene, ethyl benzene, 2,4-dinitrochlorobenzene, dichlorvos and demeton were more frequently detected in the main source water of Huaihe River basin; (3)the detection rates of dichlorvos, demeton, benzene, toluene and isopropylbenzene are all much higher than 80% in the fifty-one source water sample points; (4) the noncarcinogenic risk HQ values of the target compounds were less than one, and the cancer risk values of most source water sites were much less than the 1×10-6.Conclusion: The results of detection rate of target compounds suggested that the pollution of typical organic pollutants had been popular in the source water of the Huaihe River basin, while the concentrations data of Benzene homology, Chlorobenzene compounds, organophosphorous pesticides, and Nitrobenzene compounds in the source water of the Huaihe river basin showed that the contamination status of these chemicals was at a low level. The health risk assessment results suggested that the noncarcinogenic risk HQ values of the target compounds were less than one, and the cancer risk values of most source water sites were much less than the 1×10-6, which indicated that the heath risk produced by the target compounds in the most source water sites of the Huaihe river basin was in an acceptable level.
The perception of COVID-19, the Light Triad, harmony and ethical sensitivity in late adolescents: The role of meaning-making and stress
Authors: Krok Dariusz , Zarzycka Beata , Telka Ewa 
Published: May 2022

Abstract
Introduction: The experiences of inner harmony and ethical sensitivity among late adolescents during the COVID-19 pandemic depend on the interplay of perceptive factors, personal resources and cognitive and stress mechanisms. Using a sample from Poland, the present study examined the relationships between the perceptions of COVID-19 and the Light Triad and the characteristics of inner harmony and ethical sensitivity from the mediational perspective of meaning-making and perceived stress. Methods: Three hundred and sixteen late adolescents were recruited in the cross-sectional study. The filled in questionnaires measuring the perception of COVID-19, the Light Triad, meaning-making, stress, inner harmony and ethical sensitivity, from April to September 2020. Results: The perception of COVID-19 was negatively related to ethical sensitivity, whereas the Light Triad was positively related to inner harmony and ethical sensitivity. Perceived stress and meaning-making mediated the relationships between the perceptions of COVID-19 and the Light Triad and the characteristic of inner harmony. Discussion: Perception processes and the Light Triad dimensions directly influence ethical sensitivity, as well as indirectly affect inner harmony through meaning-making processes and perceived stress. This noticeably highlights the vital role played by meaning structures and emotional reactions in the experience of inner peace and calmness.