bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of a pilot emergency department linkage to care program for patients previously diagnosed with Hepatitis C
Authors: Hyde Zak , Roura Raúl , Signer Danielle , Patel Anuj , Cohen Jacob , Saheed Mustapha , Brinkley Sherilyn , Irvin Risha , Sulkowski Mark S. , Thomas David L. , Rothman Richard E. , Hsieh Yu‐Hsiang 
Published: November 2022

AbstractThere is a significant number of Emergency Department (ED) patients with known chronic hepatitis C virus (HCV) infection who have not been treated with directly acting antivirals. We implemented a pilot ED‐based linkage‐to‐care program to address this need and evaluated the impact of the program using the HCV Care Continuum metrics. Between March 2015 and May 2016, dedicated patient care navigators identified HCV RNA‐positive patients in an urban ED and offered expedited appointments with the on‐site viral hepatitis clinic. Patient demographics and care continuum outcomes were abstracted from the EMR and analysed to determine significant factors influencing linkage‐to‐care (LTC) and treatment initiation rates. The ED linkage‐to‐care program achieved a 43% linkage‐to‐care rate (165/384), 22% treatment rate (84/384) and 16% sustained virologic response rate (63/384). Significant associations were found between linkage‐to‐care and increasing age (OR = 1.03), Medicare insurance (OR = 2.21) and having a primary care physician (PCP) (OR = 4.03). For patients who were linked, the odds of initiating treatment were also positively significantly associated with increasing age (OR = 1.04) and having a PCP (OR = 2.77). For patients who initiated treatment, the odds of sustained virologic response were marginally associated with having a PCP (OR = 4.92).Our ED linkage‐to‐care program utilized care coordination to successfully link nearly half of approached HCV RNA‐positive patients to care. This design can be feasibly replicated by other EDs given limited non‐clinical training required for linkage‐to‐care staff. Adoption of similar programs in other EDs may improve the rates of LTC and treatment initiation for previously diagnosed HCV patients.
Machine learning‐based placental clusters and their associations with adverse pregnancy outcomes
Authors: Petersen Julie M. , Parker Samantha E. , Dukes Kimberly A. , Hutcheon Jennifer A. , Ahrens Katherine A. , Werler Martha M. 
Published: November 2022

AbstractBackgroundPlacental abnormalities have been described in clinical convenience samples, with predominately adverse outcomes. Few studies have described placental patterns in unselected samples.ObjectiveWe aimed to investigate associations between co‐occurring placental features and adverse pregnancy outcomes in a prospective cohort of singletons.MethodsData were from the Safe Passage study (U.S. and South Africa, 2007–2015). Before 24 weeks' gestation, participants were randomly invited to donate placental tissue at delivery for blinded, standardised pathological examination. We used hierarchical clustering to construct statistically derived groups using 60 placental features. We estimated associations between the placental clusters and select adverse pregnancy outcomes, expressed as unadjusted and adjusted risk ratios (RRs) and robust 95% confidence intervals (CI).ResultsWe selected a 7‐cluster model. After collapsing 2 clusters to form the reference group, we labelled the resulting 6 analytic clusters according to the overarching category of their most predominant feature(s): severe maternal vascular malperfusion (n = 117), fetal vascular malperfusion (n = 222), other vascular malperfusion (n = 516), inflammation 1 (n = 269), inflammation 2 (n = 175), and normal (n = 706). Risks for all outcomes were elevated in the severe maternal vascular malperfusion cluster. For instance, in unadjusted analyses, this cluster had 12 times the risk of stillbirth (RR 12.07, 95% CI 4.20, 34.68) and an almost doubling in the risk of preterm delivery (RR 1.93, 95% CI 1.27, 2.93) compared with the normal cluster. Small infant size was more common among the abnormal clusters, with the highest unadjusted RRs observed in the fetal vascular malperfusion cluster (small for gestational age birth RR 2.99, 95% CI 2.24, 3.98, head circumference <10th percentile RR 2.86, 95% CI 1.60, 5.12). Upon adjustment for known risk factors, most RRs attenuated but remained >1.ConclusionOur study adds to the growing body of epidemiologic research, finding adverse pregnancy outcomes may occur through etiologic mechanisms involving co‐occurring placental abnormalities.
‘Not as a Poet, but a Pioner’: Fancy and the Colonial Gaze in William Davenant's Madagascar (1638)
Authors: Working Lauren 
Published: November 2022

AbstractIn the late 1630s, the court poet William Davenant applied his literary energies to Madagascar, an island off the eastern coast of Africa: ‘Thus in a dreame, I did adventure out…/Betweene the Southern Tropick and the Line’. While previous scholarship has highlighted the poem's ambiguous attitude towards empire, focusing on the rising interest in global travel and eastern diplomacy at Charles I's court, this article revisits the poem's genre and social context by focusing on its specific engagement with colonization. In doing so, it establishes Madagascar as an important example of how cavalier poets helped shape the aesthetics of early Stuart colonialism at court. The use of fancy – explored here through poetic style and wit sociability, female colonial networks at Henrietta Maria's court, and real and imagined objects, including Malagasy artefacts – becomes key to reconciling the seeming incongruities between the poem's lover‐conquerors and the colonial aspirations that underpinned the project.
The classification of suicide gestures: Examining the validity, measurement, and level of intent of a controversial construct
Authors: Huckins‐Noss Andrew M. , Stubbing Jessica , Fox Kathryn R. , Nock Matthew K. , Millner Alexander J. 
Published: November 2022

AbstractIntroductionThe inclusion of suicide gestures in modern nomenclatures for self‐injurious thoughts and behaviors (SITB) is contentious due to their history of pejorative connotations and inconsistent operationalization and measurement. Here we sought to investigate the extent to which participants who endorse this behavior on a standardized SITB measure: (1) describe their behavior in a way that is consistent with contemporary definitions for suicide gestures; (2) accurately classify their behavior when presented with multiple SITB response options; and (3) consistently report their level of intent to die across survey items.MethodsParticipants were 83 adults from a community‐based sample who endorsed lifetime suicide gesture(s) in an online survey containing self‐report measures assessing their prior SITB engagement, followed by open‐ended questions eliciting narrative descriptions of their behaviors.ResultsApproximately 13% of participants who endorsed lifetime suicide gestures provided narrative descriptions that met criteria for the behavior, and around one‐third consistently reported zero intent to die in their explicit ratings. Additionally, some participants reported non‐zero intent to die from behaviors without direct potential for physical injury.ConclusionsOverall, this study highlights substantial issues with the validity of current approaches to measuring suicide gestures. Implications for the classification of suicide gestures in clinical and research settings are discussed.
Training in the age of liberalization and crisis: Understanding the learning experiences of young Active Labour Market Programme Participants
Authors: Papadopoulos Orestis , Jones Katy 
Published: November 2022

AbstractVocational Training has been a prominent aspect of Active Labour Market Policy (ALMP) across EU member states, as part of efforts to boost the employability and human capital of young unemployed people and address new social risks arising within knowledge economies. However, young people's learning experiences of these programmes, and how these shape their early formative experiences in the labour market is underexplored. We address this gap by presenting new analysis of an extensive qualitative dataset, involving interviews with participants in Greece's Continuous Vocational Training (CVET) Program. Drawing on Unwin and Fuller's influential theory of restrictive and expansive learning environments which was developed through examination of formal apprenticeship programmes, we explore the extent to which these short‐term vocational training programs provide meaningful learning and work experiences for young people. We show that vocational training facilitated through ALMPs is often experienced as restrictive, underpinned by a lack of meaningful training, occupation‐specific skills, supportive guidance and quality employment prospects. Furthermore, we show how ALMPs in such contexts not only fail to support young people, but they also reinforce and legitimize precarious work practices by socializing the younger generation of workers into low‐pay, temporary and routine jobs.
Diagnostic effectiveness of stress biomarkers in cats with feline interstitial and bacterial cystitis
Authors: Gülersoy Erdem , Maden Mehmet , Parlak Tuğba Melike , Sayin Zafer 
Published: November 2022

AbstractBackgroundAlthough bacterial cystitis (BC) and feline interstitial cystitis (FIC) are categorized under feline lower urinary tract disease (FLUTD) due to their similar clinical manifestations, stress is an important factor for FIC. Therefore, the investigation of stress biomarkers might be important in the differentiation and elucidation of these conditions.ObjectivesWe aimed to evaluate the diagnostic effectiveness of serum and urine cortisol, serotonin, and dopamine concentrations and their relationship with stress in cats with FIC and BC.MethodsTwelve healthy cats (Control group) and 24 cats with FLUTD were used. The cats with FLUTD were divided into FIC and BC groups.ResultsMultimodal environmental modification (MEMO) scores were found to be higher in the FIC group than in the BC and Control groups (P < .001). Urine serotonin concentrations were higher in cats with FIC and BC compared with those in the Control group. Based on ROC analyses, the sensitivity, specificity, and accuracy of urine serotonin and dopamine were found to be statistically significant in being able to differentially diagnose cats in the FIC group vs the Control group. The sensitivity, specificity, and accuracy of serum dopamine were also found to be statistically significant for the differential diagnosis of FIC and BC.ConclusionsHigh urine serotonin concentrations were found in cats with FLUTD compared with healthy controls and interpreted as the presence of stress not only in cats with FIC but also in cats with BC. Also, based on the ROC‐based diagnostic performance evaluation of these stress biomarkers, urine serotonin, and dopamine concentrations can be used to diagnose FIC, and serum dopamine concentrations can be used to differentiate FIC and BC in cats.
Englishes of the Caribbean: A research bibliography
Authors: Schmalz Mirjam , Meer Philipp 
Published: November 2022

AbstractThe research bibliography presented in this paper lists some of the major research outputs on Englishes in the Caribbean. While selected foundational studies are listed, the focus lies on works published since the year 2000. Considering the linguistic diversity of the anglophone Caribbean, the publications listed include works on English‐based Creoles, Englishes, mesolectal language use and mixed codes, as well as English‐related contact varieties. A particular focus is on works investigating standardized (or standardizing) varieties of English spoken in the region. Efforts were made to represent both larger and smaller territories and islands. Potential limitations notwithstanding, we hope that this bibliography will prove useful to researchers and students interested in Caribbean varieties of English.
Reviewer Acknowledgements for Studies in Media and Communication, Vol. 10, No. 2
Authors: Johnson Patricia 
Published: November 2022

Studies in Media and Communication (SMC) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether SMC publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 10, Number 2Aina Fernàndez Aragonès, Tecnocampus-UPF, SpainAmie Jones, University of Georgia, USAAndreas Veglis, Aristotle University of Thessaloniki, GreeceAyşe Aslı Sezgin, Çukurova University, TurkeyBernard Naledzani Rasila, University of Venda, South AfricaCaitlin McLaughlin, St. Francis Xavier University, CanadaCamelia Cmeciu, Danubius University of Galati, RomaniaCarmen Pérez-Sabater, Universitat Politècnica de València, SpainChristof Demont-Heinrich, University of Denver, USAFrancis Adyanga Akena, Kabale University Uganda, UgandaHerman, Universitas HKBP Nommensen Pematangsiantar, IndonesiaImed Ben Labidi, Doha Institute for Graduate Studies, USAIrina Milutinović, Institute of European Studies, Belgrade, SerbiaJianbo Hou, Xi'an International Studies University, ChinaLambrini Papadopoulou, National and Kapodistrian University, GreeceMaría José Serrano, Universidad de La Laguna, SpainMasduki Masduki, Universitas Islam Indonesia, IndonesiaMatthias Degen, Westphalian University of Applied Sciences, GermanyMunira Fayzulloeva, Tajik State University of Law, TajikistanNavid Darvishzadeh, Georgia State University, USANina Gunnarsson, Jönköping university, SwedenNingyang Chen, Soochow University, ChinaPeggy Peattie, University of San Diego, USAPhilemon Bantimaroudis University of Cyprus, CyprusRefat Aljumily, Newcastle University, UKSixto-García José, University of Santiago de Compostela, SpainTilahun Adamu Mengistie, University of Gondar, EthiopiaVerlumun Celestine Gever, University of Nigeria, NigeriaXiao Li, Hubei Institute of Fine Arts, ChinaYoung Joon Lim, University of Texas Rio Grande Valley, USAPatricia JohnsonEditorial AssistantOn behalf of,The Editorial Board of Studies in Media and CommunicationRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://smc.redfame.com
Effectiveness of transitional care interventions in patients with serious illness and their caregivers: a systematic review protocol
Authors: Caggianelli Gabriele , Sferrazza Silvia , Pampoorickal Kusumam , Accettone Roberto , Di Nitto Marco , Ivziku Dhurata , Fiorini Jacopo , D’Angelo Daniela 
Published: November 2022

Objective:
The objective of this review is to evaluate the effectiveness of transitional care interventions for seriously ill patients and their caregivers.

Introduction:
Seriously ill patients and their caregivers may have complex health and social care needs that require services from numerous providers across multiple sectors. Transitional care interventions have been designed to enhance a collaborative approach among providers to facilitate the care transition process. However, the effectiveness of transitional care interventions for seriously ill patients, their caregivers, and the effects of such interventions on their outcomes remain unclear.

Inclusion criteria:
Randomized controlled trials with adult patients (≥18 y old) with serious illness and their caregivers involved in transitional care programs will be considered for inclusion. The patients’ outcomes will include mortality and/or survival, symptoms (eg, pain, nausea), and health-related quality of life. The caregivers’ outcomes will include caregiver burden, preparedness, and well-being.

Methods:
The JBI methodology for systematic reviews of effectiveness evidence will be followed. The search strategy aims to locate published and unpublished studies. Electronic databases, including PubMed, Embase, CINAHL, and the Cochrane Central Register of Controlled Trials, will be systematically searched from 2003 to the present. Studies in English, Italian, Spanish, French, and German will be included. Critical appraisal and data extraction will be conducted using standardized tools. Quantitative data will be pooled in statistical meta-analysis or, if statistical pooling is not possible, the findings will be reported narratively. Certainty of the evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE).

Systematic review registration number:
PROSPERO CRD42022319848
Colitis aggravated by Mrgprb2 knockout is associated with altered immune response, intestinal barrier function and gut microbiota
Authors: Shao Ming , Liu Jingwen , Luo Hesheng 
Published: November 2022

AbstractUlcerative colitis (UC) is a chronic immune‐related disease, and changes in the intestinal microbiota and damage to the intestinal barrier contribute to its pathogenesis. Mast cells (MCs) are widely distributed in the gastrointestinal tract and are thought to be related to the pathogenesis of UC. Human mas‐related G protein‐coupled receptor X2 (MRGPRX2) and its mouse homologue, Mrgprb2, are selectively expressed on MCs to recruit immune cells and modulate host defence against microbial infection. To investigate the role of Mrgprb2 in UC in mice, we compared the differences between Mrgprb2 knockout (b2KO) male mice and wild‐type (WT) male mice with dextran sulfate sodium (DSS)‐induced colitis in the severity of clinical symptoms, inflammatory cell infiltration, degree of intestinal barrier damage and composition of the intestinal flora. The results showed that weight loss, disease activity index score, colon shortening and colonic pathological damage were significantly increased in b2KO mice while MC activation, cytokine and chemokine secretion, and inflammatory cell infiltration were decreased. In addition, the abundance and diversity of the intestinal microbiota were reduced in b2KO mice. B2KO mice also exhibited a reduction of probiotics such as norank_f_Muribaculaceae and Lactobacillus and increase of harmful bacteria like Escherichia–Shigella. Intestinal mucosal barrier damage of b2KO mice was more severe than that of WT mice due to the attenuated expression of mucin‐2 and occludin. These results demonstrated that MRGPRB2 may have a protective effect on DSS‐induced colitis by altering the intestinal flora, participating in barrier repair and recruiting inflammatory cells to eliminate pathogens.
Advances in diagnosis and treatment of testicular cancer
Authors: Chovanec Michal , Cheng Liang 
Published: November 2022

Abstract
Testicular cancer is a curable cancer. The success of physicians in curing the disease is underpinned by multidisciplinary advances. Cisplatin-based combination chemotherapy and the refinement of post-chemotherapy surgical procedures and diagnostic strategies have greatly improved long term survival in most patients. Despite such excellent outcomes, several controversial dilemmas exist in the approaches to clinical stage I disease, salvage chemotherapy, post-chemotherapy surgical procedures, and implementing innovative imaging studies. Relapse after salvage chemotherapy has a poor prognosis and the optimal treatment is not apparent. Recent research has provided insight into the molecular mechanisms underlying cisplatin resistance. Phase 2 studies with targeted agents have failed to show adequate efficacy; however, our understanding of cisplatin resistant disease is rapidly expanding. This review summarizes recent advances and discusses relevant issues in the biology and management of testicular cancer.
One-year mortality after acute stroke: a prospective cohort study from a comprehensive stroke care centre, Kerala, India
Authors: Nambiar Vivek , Raj Manu , Vasudevan Damodaran , Bhaskaran Renjitha , Sudevan Remya 
Published: November 2022

ObjectivesThe primary objective was to report the 1-year all-cause mortality among patients with stroke. The secondary objectives were (1) to report the mortality stratified by type of stroke and sex and (2) to report predictors of 1-year mortality among patients with stroke.DesignA prospective cohort study.SettingInstitutional–stroke care unit of a tertiary care hospitalParticipantsPatients who were treated in the study institution during 2016–2020 for acute stroke and were followed up for a period of 1 year after stroke in the same institution.Main outcome measuresThe main outcome measures were the mortality proportion of any stroke and first ever stroke cohorts at select time points, including in-hospital stay, along with 2 weeks, 2 months, 6 months and 1 year after index stroke. The secondary outcomes were (1) mortality proportions stratified by sex and type of stroke and (2) predictors of 1-year mortality for any stroke and first ever stroke.ResultsWe recruited a total of 1336 patients. The mean age of participants was 61.6 years (13.5 years). The mortality figures for 2 weeks, 2 months, 6 months and 12 months after discharge were 79 (5.9%), 88 (6.7%), 101 (7.6%) and 114 (8.5%), respectively, in the full cohort. The in-hospital mortality was 45 (3.4%). The adjusted analysis revealed 3 predictors for 1-year mortality after first ever stroke—age, pre-treatment National Institutes of Health Stroke Scale (NIHSS) score and Modified Rankin Scale (mRS) score at baseline. The same for the full cohort had only two predictors—age and pre-treatment NIHSS score.ConclusionMortality of stroke at 1-year follow-up in the study population is low in comparison to several studies published earlier. The predictors of 1-year mortality after stroke included age, NIHSS score at baseline and mRS score at baseline.
Exploration of physiotherapists’ use of motor control strategies for the treatment of idiopathic toe walking in children: a qualitative study
Authors: Caserta Antoni , Morgan Prue , Williams Cylie 
Published: November 2022

ObjectivesTo explore how motor control interventions are conceptualised during treatment of children with idiopathic toe walking (ITW) by physiotherapists in Australia and USA.DesignA thematic content framework qualitative design was used to triangular the theories underpinning motor control interventions and participant responses.ParticipantsTen paediatric physiotherapists were recruited from Australia and USA. Participation was only open to physiotherapists who provided treatment to children with ITW.ResultsPhysiotherapists defined the motor control interventions used for children with ITW as having the following non-hierarchical key elements:use of repetition; task scaffolding; encouraging error recognition; and, active and/or passive movements. Physiotherapists also described two superordinate themes; (1) We see motor control through the lens of how we view managementand (2) Idiopathic toe walking treatment is a game with rules that are made to be broken.ConclusionsTreatment of ITW continues to challenge clinicians. Physiotherapists viewed their approach to ITW management being evidence- informed, underpinned by motor learning theories, movement strategies and organisational treatment frameworks or guidelines to fit their individual childrens’ needs. Future research should investigate if this approach affords more favourable outcomes for children with ITW gait.