bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of ABO Blood Grouping among Hemodialysis Patients in Dubai
Authors: Alalawi Fakhriya , Gulzar Kashif , Galaleldin Waleed Mohamed , Alhadari Amna 
Published: May 2022

Background:
Beyond their vital role in blood transfusion, ABO antigens were speculated to be involved in developing various human illnesses, including
infectious, neoplastic, cardiovascular, and many others. Many researchers attempted to highlight the relationship between kidney disease and ABO
phenotypes. The majority of these reports showed a predominance of blood group O antigen among patients with chronic kidney disease, while
few had opposed these findings. We aimed in this study to elaborate on blood group typing among our hemodialysis patients and whether it has a
prognostic effect on the overall mortality.

Methods:
This is an observational, cross-sectional, retrospective study among chronic adult hemodialysis patients being dialyzed at Dubai Hospital over the
past six months, from Jan 2021 till June 2021. The patient's demographic characteristics (age, sex, etiology of chronic kidney disease, medical
comorbidities, and blood groups) were retrieved using an electronic hospital medical record system.

Results:
Our study population constituted 224 hemodialysis patients; their mean age was 55.4 years (16-94 years), 83.6% were UAE nationals, and 59.8%
were males. Diabetic nephropathy was the etiology of end-stage kidney disease in 46%. ABO blood group distribution among our study population
was as follows; group O was the commonest (45%), followed by group B positive (23%) and A Positive (20.9%). Among the UAE national
patients group, O+ constitutes 46.9%, followed by B+ in 24%, and A+ in 21%. Nevertheless, group O+ was still the commonest among the nonnational hemodialysis patients in 37.7%, A+ in 28.8%, and B+ in 24.4%. Additionally, group O-positive was the predominant group among all
diabetic dialysis patients (47%). Nine patients died during the study period of different causes; out of them, 4 patients (44.4%) had group O
positive.

Conclusion:
Blood group O was the commonest blood group among our hemodialysis patients. Additionally, it was the commonest group in all diabetic dialysis
patients. More studies from Arab countries are needed to comprehend the relationship between ABO blood phenotypes and kidney disease and
whether certain blood groups have any role in a patient's progression to ESKD.
Evolution of Interdisciplinary Approaches Among Research-Oriented Universities in Vietnam Toward a Modern Industrial Economy: Exploratory Study
Authors: Tran Bach Xuan , Nguyen Long Hoang , Nguyen Hao Anh Si , Vu Thuc Minh Thi , Do Anh Linh , Nguyen Lien Thi Khanh , Kim Nga Thanh Ngoc , Trinh Trang Thu Hong , Latkin Carl , Ho Cyrus S H , Ho Roger C M 
Published: May 2022

Background
Vietnam’s 2045 development plan requires thorough reforms in science and technology, which underlines the role of research-oriented universities in generating and transforming knowledge. Understanding the current research performance and productivity in Vietnam is important for exploiting future agendas.

Objective
This study aims to explore the growth patterns and collaborations in the scientific publications of Vietnam.

Methods
Data on documents in the Web of Science Core Collection database were searched and extracted to examine the research performance in Vietnam. Publication growth patterns in both quantity and quality were examined. The evolution of research disciplines and collaboration networks were also analyzed. Trends in the growth in the number of publications, citations, and average citations per publication between 1966 and 2020 were presented. Temporal tendencies of the 10 most productive research areas in each period were illustrated. VOSviewer software was used to analyze the discipline network, country network, and institution networks. The trends and the geographical distribution of the number of publications and citations were analyzed.

Results
A total of 62,752 documents in 8354 different sources from 1966 to 2020 were retrieved. A substantial growth was observed in the Vietnamese scientific output during this period, which was mainly research with international collaboration. Natural sciences such as mathematics, materials science, and physics were the top 3 most productive research fields during 1966-2020 in Vietnam, followed by experimental research fields such as multidisciplinary sciences, plant sciences, public, environmental, and occupational health. In 1966-2020, there was the emergence of multidisciplinary research–oriented universities in both public and private sectors along with a significant increase in the number of interdisciplinary and multidisciplinary publications. Although the scientific quality has improved, these publications are still of mostly medium quality as they are concentrated in middle-ranking journals.

Conclusions
Our study highlights the notable growth in research performance in terms of both quality and quantity in Vietnam from 1966 to 2020. Building multidisciplinary and interdisciplinary research agenda, developing networks of local and international researchers for addressing specific local issues, improving the participation of private sectors, and developing science and technology mechanisms are critical for boosting the research productivity in Vietnam.
An Integrated mHealth App for Smoking Cessation in Black Smokers With Anxiety: Protocol for a Randomized Controlled Trial
Authors: Businelle Michael S , Garey Lorra , Gallagher Matthew W , Hébert Emily T , Vujanovic Anka , Alexander Adam , Kezbers Krista , Matoska Cameron , Robison Jillian , Montgomery Audrey , Zvolensky Michael J 
Published: May 2022

Background
Black smokers have greater difficulty in quitting and higher rates of smoking-related diseases and disabilities than the general population. The smoking disparities experienced by this group are, in part, a consequence of multiple chronic life stressors (eg, racial discrimination) that engender increased exposure to interoceptive stress symptoms (eg, anxiety), which can ultimately lead to smoking as a means of immediate emotion regulation.

Objective
This study aimed to culturally adapt and initially test a novel mobile intervention (ie, Mobile Anxiety Sensitivity Program for Smoking [MASP]) that targets anxiety sensitivity (AS; a proxy for difficulty and responsivity to interoceptive stress) among Black smokers. The MASP intervention is culturally informed to address interoceptive stress management difficulties among Black smokers and is thus hypothesized to facilitate smoking cessation.

Methods
In phase 1, a total of 25 Black smokers with elevated AS will be administered MASP for 6 weeks. Following the completion of phase 1, we will further refine the MASP based on qualitative and quantitative data from participants to produce the final MASP iteration. In phase 2, a total of 200 Black smokers with elevated AS will be enrolled and randomly assigned to receive nicotine replacement therapy and either the smartphone-based National Cancer Institute QuitGuide app for standard mobile smoking cessation treatment or the MASP intervention. All participants in phases 1 and 2 will be enrolled remotely and will complete a web-based study screener; smartphone-based baseline assessment; daily smartphone-based ecological momentary assessments for 6 weeks; phone-based end-of-treatment qualitative interviews; and smartphone-based follow-up assessments at postbaseline weeks 1, 2 (quit date), 3, 4, 5, 6, 28, and 54 (weeks 28 and 54 follow-ups will be completed by phase 2 participants only). The MASP intervention is intended to offset barriers to treatment and encourage treatment engagement via smartphones.

Results
This project was funded in September 2020. Phase 1 data collection began in January 2022. Phase 2 data collection is scheduled to begin in July 2022.

Conclusions
If successful, data from this study will support culturally informed treatment approaches for Black smokers and, pending findings of efficacy, provide an evidence-based mobile intervention for smoking cessation that is ready for dissemination and implementation.

Trial Registration
ClinicalTrials.gov NCT04838236; https://clinicaltrials.gov/ct2/show/NCT04838236

International Registered Report Identifier (IRRID)
DERR1-10.2196/38905
Konsepsi Marital Rape dalam Fikih Munakahat
Authors: Syaifuddin Muhammad irfan 
Published: May 2022

Marital rape menjadi kajian penting dalam isu-isu gender dalam beberapa dekade terakhir di Indonesia. Para penggiat kesetaraan gender khususnya feminist menggambil peran dalam menyuarakan marital rape sebagai bagian kekerasan dalam rumah tangga, yang bagi pelakunya bisa dikenai pidana. Terbitnya UU No. 23 Tahun 2004 tentang Penghapusan Kekerasan Dalam Rumah Tangga (PKDRT) menjadi jawaban terhadap kegelisaan para penggiat HAM khususnya untuk perempuan akan keberpihakan negara dalam melindungi setiap warga yang mendapatkan tindakan kekerasan sekalipun dalam ruang private, yaitu rumah tangga. Jika sebelumnya, kekerasan dalam rumah tangga tidak diatur khusus dalam KUHP dan hanya menjadi delik aduan umum, dalam UU PKDRT diatur dengan jelas dan rigid, marital rape dikategorikan ke dalam kekerasan seksual dan pelakunya dikenai hukuman pidana 12 tahun penjara atau denda sebesar 36 juta rupiah. Namun menjadi ironi jika kita melihat ke dalam litaratur fikih munakahat belum banyak dikemukakan pendapat ahli tentang bagaimana konsep dan hukum marital rape. Maka menumbuhkan kesadaran para ahli fikih akan petingnya konsep marital rape mutlak diperlukan, sehingga bukan hanya berdasar kepada ketentuan dalam hukum positif saja, tapi ketentuan dalam hukum Islam yang tegas terhadap marital rape.
Kebijakan Pemerintah Kabupaten Sukoharjo dalam Menciptakan Iklim Investasi yang Kondusif
Authors: Dona Fery 
Published: May 2022

Penelitian ini bertujuan untuk mengetahui kebijakan Pemerintah Daerah Kabupaten Sukoharjo dalam menciptakan iklim investasi yang kondusif, dan untuk mengetahui apa saja hambatan yang dihadapi Pemerintah Daerah Kabupaten Sukoharjo dalam menciptakan iklim investasi yang kondusif.
Penelitian ini menggunakan jenis penelitian empiris, yang diteliti pada awalnya adalah data sekunder kemudian dilanjutkan dengan penelitian terhadap data primer. Analisis data menggunakan deskripsi kualitatif, yaitu hasil pengelolahan data kualitatif ini digambarkan dengan kalimat dipisahkan berdasarkan kategori untuk memperoleh kesimpulan.
Hasil penelitian menunjukan bahwa kebijakan Pemerintah Daerah Kabupaten Sukoharjo dalam menciptakan iklim investasi yang kondusif antara lain membangun gedung pusat promosi potensi daerah, menetapkan Peraturan Bupati No. 38 tahun 2015 tentang Rencana Umum Penanaman Modal Kabupaten Sukoharjo tahun 2015-2025, menetapkan Peraturan Bupati Sukoharjo No. 2 tahun 2017 tentang Standar Pelayanan Pada Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu Kabupaten Sukoharjo, menetapkan Peraturan Bupati Sukoharjo No. 4 tahun 2017 tentang Layanan Perizinan Online dan Secara Mandiri di Kabupaten Sukoharjo, menetapkan Peraturan Bupati Sukoharjo No. 32 tahun 2017 tentang Pendelegasian Kewenangan Di Bidang Perizinan dan Non Perizinan Kepada Kepala Dinas Penanaman Modal dan Pelayanan Terpada Satu Pintu, menetapkan Peraturan Bupati Sukoharjo No. 1 tahun 2018 tentang Perubahan Atas Peraturan Daerah Kabupaten Sukoharjo No. 14 tahun 2011 tentang Rencana Tata Ruang Wilayah Kabupaten Sukoharjo tahun 2011-2031, mengikuti promosi investasi. Kemudian juga diperoleh hasil mengenai hambatan yang dihadapi Pemerintah Daerah Kabupaten Sukoharjo dalam menciptakan iklim investasi yang kondusif antara lain Sukoharjo belum mempunyai terminal peti kemas, ada penolakan dari masyarakat terhadap izin tertentu salah satunya adalah izin menara telekomunikasi, adanya protes dari masyarakat kepada pelaku usaha yang disebabkan kelalaian pelaku usaha.
1234-P: Serum Fatty Acid Composition as a Biomarker of Diabetes Development: Tokushima Cohort Study
Authors: HATA AKIKO , AKI NANAKO , ICHIHARA TAKAKO , TAMURA AYAKO , MINAGAWA TAKAKO , KUWAMURA YUMI , FUNAKI MAKOTO 
Published: May 2022

Few prospective cohort studies still exist on the association between serum fatty acid (FA) proportions and the enzymes involved in their synthesis and the onset of type 2 diabetes (T2D) . Thus, the aim of the present study was to investigate whether or not serum FA proportions or FA ratios, which reflect desaturase activities, are associated with the incidence of T2D. Here we analyzed data of a prospective cohort study, which was conducted during 2010-20in Japan. A total of 872 male workers without diabetes aged over 20 years were followed up prospectively. Diabetes was defined as having either: 1) fasting plasma glucose ≥ 126 mg/dl, 2) HbA1c ≥ 6.5%, 3) medication for hyperglycemia or 4) postprandial plasma glucose ≥ 200 mg/dl during the follow-up period. We measured serum FA levels and estimated the activity of ⊿5desaturase (D5D) by calculating the ratio of serum arachidonic acid to dihomo-γ-linolenic acid (DGLA) . The subjects were also divided into two groups by the cutoff point of waist circumference (WC) ≥ 90 cm. In multivariate analysis, the HR of developing diabetes was 2.81 [95%CI: 1.to 7.15, P=0.03] in the highest quartile of serum DGLA proportion and 0.28 [95%CI: 0.to 0.90, P=0.03] in the highest quartile of D5D, compared with their lowest quartiles, respectively. In stratified analysis, the multivariate adjusted risk of diabetes was higher in participants with low D5D/low WC (2.56 [0.96 to 6.82]) or high D5D/high WC (2.77 [0.68 to 11.32]) , and was significantly higher in participants with low D5D/high WC (6.30 [1.95 to 20.33, P=0.002]) than in participants with high D5D/low WC. Our findings suggest that the combination of increased serum DGLA proportion and attenuated D5D activity is a risk factor for the incidence of diabetes in male Japanese, especially in those with WC ≥ 90 cm. Thus, the significance of serum FA measurements in predicting T2D is suggested.

Disclosure
A.Hata: None. N.Aki: None. T.Ichihara: None. A.Tamura: None. T.Minagawa: None. Y.Kuwamura: None. M.Funaki: Board Member; Mechanogenic, Inc.

Funding
Grants-in-aid for research from Tokushima Prefecture Local Government
1288-P: Increased Adipose Tissue Expression of IL-23 and Its Association with Inflammation in Individuals with High LDL Cholesterol
Authors: AHMAD RASHEED , KOCHUMON SHIHAB P. , HASAN AMAL , SINDHU SARDAR T. , AREFANIAN HOSSEIN , ALRASHED FATEMA , ALMULLA FAHD 
Published: May 2022

Obesity induced chronic low-grade inflammation is a central risk factor for the development of metabolic syndrome. It has been well documented that high LDL-c induces inflammation. The proinflammatory cytokine Il-23 plays a pivotal role in the pathogenesis of inflammatory diseases. IL-23 and its relationship with LDL- c has not been reported yet. In this cross-sectional study we investigated whether adipose tissue expression of IL-23 associated with the other inflammatory mediators in individuals with high serum levels of low-density lipoprotein cholesterol (LDL-c) . Subcutaneous adipose samples were collected from 67 individuals and divided into two groups based on their serum LDL-c levels (LDL-c: &lt; 2.9 or ≥2.9 mmol/L) . Expression of IL-23 and inflammatory markers was determined using real-time RT-PCR. Plasma lipid measurements included total cholesterol (TC) , triglyceride (TG) , high-density lipoprotein cholesterol (HDL-c) and LDL-c by standard methods, and serum adiponectin was measured by enzyme-linked immunosorbent assay (ELISA) . Individuals with increased serum levels of LDL-c showed high IL-23 expression levels in adipose tissue (p &lt; 0.011) . AT IL-23 expression was correlated positively with LDL-c (r= 0.39, p &lt; 0.0001) . IL-23 expression levels were positively correlated with macrophage markers (CD11c, CD68, CD86, CD127; (r ≥0.37, p≤ 0.02) , TLRs (TLR8, TLR10; (r ≥ 0.39, p ≤ 0.022) , IRF3 (r= 0.46, p&lt; 0.01) , cytokines (TNF-α, IL-12, IL-18; (r ≥ 0.35, p ≤ 0.04) , chemokines (CXCL8, CCL3, CCL5, CCL15, CCL20; (r ≥0.43, p ≤ 0.01) . Notably, IL-23 is negatively correlated with adiponectin (r=-0.44, p &lt; 0.03) in the individuals with high LDL-c. However, such association of IL-23 with inflammatory markers was not found in the individuals with low LDL-c.
In conclusion, adipose tissue IL-23 may be a biomarker for inflammation progression in the individuals with high LDL-c and could be used as a therapeutic target for the treatment of metabolic syndrome.

Disclosure
R.Ahmad: None. S.P.Kochumon: None. A.Hasan: None. S.T.Sindhu: None. H.Arefanian: None. F.Alrashed: None. F.Almulla: None.

Funding
Kuwait Foundation for Advancement of Sciences (RA-2010-003)
1296-P: Adipose Tissue Insulin Resistance in RISE: Divergence between Youth and Adults, and Females and Males
Authors: ARSLANIAN SILVA A. , CAPRIO SONIA , NADEAU KRISTEN J. , TEMPLE KARLA A. , WANDER PANDORA , CREE-GREEN MELANIE , HANNON TAMARA S. , KAHN STEVEN E. , GHORMLI LAURE EL ,   THE RISE CONSORTIUM
Published: May 2022

Adipose tissue insulin resistance (Adipose-IR) is a pathophysiological component of type 2 diabetes (T2D) . We examined:1) Adipose-IR (calculated as fasting insulin x free fatty acids [FFAs]) in youth and adults with impaired glucose tolerance (IGT) or recently diagnosed T2D;2) sexual dimorphism in Adipose-IR in each age group;3) the association of Adipose-IR with β-cell function (βCF) in youth and adults.In RISE, 91 youth [BMI 36.7±24.4 (SD) kg/m2, 59.3% IGT] and 355 adults [BMI 35.1±5.1 kg/m2, 70.7% IGT] had baseline Adipose-IR measured. The relationship of Adipose-IR to hyperglycemic-clamp-derived-βCF and insulin sensitivity (IS) were assessed. Adipose-IR was 2.2-fold higher in youth vs. adults (p&lt;0.001; Fig A) , higher in females than males in both age groups (p&lt;0.05; Fig B) , and higher in T2D vs. IGT in youth (p&lt;0.05; Fig C) . In adults, Adipose-IR correlated positively with all clamp-derived βCF parameters, while in youth it only correlated with steady-state C-peptide. In both age groups, Adipose-IR correlated inversely with clamp-IS. Youth, whether males or females, have 100% higher adipose tissue insulin resistance compared with adults. Moreover, within each age group, females have greater Adipose-IR than males. The higher Adipose-IR in youth vs. adults across a wide range of BMI is suggestive of other yet unknown factors, possibly puberty-related, potentially modulating Adipose-IR.

Disclosure
S.A.Arslanian: Advisory Panel; Eli Lilly and Company, Novo Nordisk, Other Relationship; AstraZeneca, Research Support; Eli Lilly and Company, Novo Nordisk. T.Consortium: None. S.Caprio: None. K.J.Nadeau: None. K.A.Temple: None. P.Wander: None. M.Cree-green: None. T.S.Hannon: Advisory Panel; Eli Lilly and Company. S.E.Kahn: Advisory Panel; Bayer AG, Boehringer Ingelheim International GmbH, Eli Lilly and Company, Intarcia Therapeutics, Inc., Merck & Co., Inc., Novo Nordisk, Pfizer Inc. L.El ghormli: None.

Funding
American Diabetes Association (1-20-RISE-01) ; NIDDK, Department of Veterans Affairs, and Kaiser Permanente Southern California
1299-P: Novel Tools to Dissect the Metabolic Roles of Central and Peripheral Dopamine D2-Like Receptors
Authors: BONIFAZI ALESSANDRO , ELLENBERGER MICHAEL P. , FARINO ZACHARY , RAIS RANA , MANTILLA-RIVAS JOSÉ , ASLANOGLOU DESPOINA , JANOWSKY AARON , SLUSHER BARBARA , SCHWARTZ GARY J. , NEWMAN AMY H. , FREYBERG ZACHARY 
Published: May 2022

Dopamine (DA) D2-like receptors are key physiological modulators of metabolism under healthy and disease states. While D2-like receptors are expressed both in the central nervous system (CNS) and within the periphery, the respective metabolic roles of CNS and peripheral D2-like receptors remain poorly understood. Therefore, to disentangle these CNS versus peripheral contributions, we synthesized a series of new peripherally-limited D2-like receptor agonists. We selected bromocriptine methiodide, a quaternary methiodide (MeI) analog of bromocriptine as our lead compound based on preservation of its binding and functional efficacy at D2-like receptors and its diminished blood brain barrier permeability. Systemic administration of bromocriptine, with unrestricted access to both CNS and peripheral targets, significantly improved both insulin sensitivity and glucose tolerance in obese, insulin-resistant mice in vivo. In contrast, metabolic improvements were abolished when bromocriptine’s access was restricted either to the CNS through intracerebroventricular administration or to the periphery via the peripherally-limited bromocriptine MeI. Our findings therefore suggest that the coordinated actions of both CNS and peripheral D2-like receptors are required for bromocriptine’s therapeutic efficacy in correcting dysglycemia. Overall, bromocriptine MeI may serve as a useful new tool to further dissect these mechanisms of peripheral DA signaling.

Disclosure
M.P. Ellenberger: None. Z. Farino: None. J. Mantilla-Rivas: None. B. Slusher: None.

Funding
Department of Defense (PR141292) , National Institutes of Health (R01DK124219)
1420-P: Gestational Diabetes Glyburide Treatment and Glycemic Control: Associations with Risk of Subsequent Child Obesity
Authors: JOSEFSON JAMI L. , SUN BAIYANG , GREENBERG MARA , GREENSPAN LOUISE , DAVIS JAIMIE N. , METZGER BOYD E. , LO JOAN C. , FAITH MYLES S. , LOWE WILLIAM , GUNDERSON ERICA P. 
Published: May 2022

Gestational diabetes mellitus (GDM) increases offspring obesity risk. GDM severity, treatment, glycemic control and postnatal feeding behaviors increase or alleviate child obesity risk. This study sought to evaluate GDM treatment (glyburide vs. diet) and glycemic control related to overweight/obesity risk in toddlers of mothers with GDM. In a diverse prospective cohort of 786 GDM mother-child dyads (78% minority: Hispanic, Asian, Black and 22% White) , we measured prenatal glycemic control (daily home testing) , GDM severity, treatment, postnatal diet, and child BMI at age 2-5 y. Maternal glycemia was categorized as optimal control (≥80% of fasting & post-prandial blood glucose tests met target) or not optimal control (&lt;80%) . Child weight and height was categorized by BMI percentiles (age, sex) ; normal weight (&lt;85th) , overweight (85-95th) or obese (&gt;95th) . Multinomial logistic regression estimated odds ratios (OR) 95%CI of overweight and obesity associated with treatment and glycemic control adjusted for prenatal, newborn and postnatal covariates. On average, mothers were 33.3 (SD 4.7) y at delivery with prepregnancy BMI 29.3 (7.1) kg/m2 and 74% had optimal glycemic control. Children were age 40.5 (6.3) months at BMI measurement; 76% normal weight, 13% overweight and 11% obese. Glyburide was associated with higher risk of obesity, 1.75 (1.05-2.91) independent of glycemic control. Stratifying by glycemic control, glyburide was associated with borderline higher odds of obesity (2.79, 0.94-8.33, p=0.065) among those not in optimal control adjusted for GDM severity, pre-pregnancy BMI, sociodemographic, newborn size and infant diet. Longer breastfeeding was associated with lower odds of obesity (0.83, 0.75-0.93) and sugary drink or fruit juice intake birth to 1 y was associated with higher odds of obesity (4.14, 1.06-16.19) . Glyburide treatment of GDM and sugary infant diet may contribute to obesity in young children if maternal glycemic control was not optimal.

Disclosure
J.L.Josefson: n/a. E.P.Gunderson: None. B.Sun: None. M.Greenberg: None. L.Greenspan: None. J.N.Davis: None. B.E.Metzger: None. J.C.Lo: None. M.S.Faith: None. W.Lowe: None.

Funding
National Institutes of HealthRDK122700