bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Subperineural Resection Technique in Vestibular Schwannomas: Surgical Efficacy and Outcomes in 124 patients
Authors: Wu Yingxi , Wei Chen , Wang Ping , Zhang Yunze , Wu Yang , Xue Yafei , Zhao Tianzhi , Qu Yan 
Published: April 2022

ObjectiveWe aimed to explore the application and prospects of the subperineural resection technique for tumor separation and removal under the perineurium during surgery for vestibular schwannomas (VSs).MethodsThis study retrospectively analyzed 124 patients with VSs who underwent surgery via a retrosigmoid approach from July 2015 to October 2020 in the Department of Neurosurgery, Tangdu Hospital, Air Force Military Medical University. The data will be discussed with regard to the following aspects: clinical features, surgical strategies, tumor resection extent, facial–acoustic function preservation, and postoperative complications.ResultsGross total resection (GTR) of the tumor was achieved in 104 patients, with a GTR rate of 83.9%, and subtotal resection (STR) of the tumor was achieved in 20 patients. There was no significant difference in facial and acoustic nerve functional preservation between GTR and STR, as well as in tumor resection between solid and cystic tumors. The retention rate reached 97.6% in terms of complete anatomical facial nerve preservation. Facial nerve function was assessed using the House–Brackmann (HB) grading score. Consequently, HB grades of I–II, III–IV, and V–VI were determined for 96 (77.4%), 25 (20.2%), and 3 (2.4%) cases, respectively, 1 week postoperatively and accounted for 110 cases (88.7%), 13 cases (10.5%), and 1 case (0.8%), respectively, at 6 months. Fifteen of 35 (42.9%) patients with serviceable hearing before the operation still had serviceable hearing at 6 months postoperatively. There were 5 cases of cerebellar or brainstem bleeding after the operation, and one patient died. Multivariate logistic regression analysis showed that older age (≥60 years, p = 0.011), large tumor (&gt;3 cm, p = 0.004), and cystic tumor (p = 0.046) were independent risk factors associated with the extent of adhesion between the tumor and the brainstem and facial–acoustic nerve.ConclusionWe successfully applied the subperineural resection technique to a large series of patients with VSs and achieved satisfactory results. Accurate identification of the perineurium and subperineural resection of the tumor can effectively reduce the disturbance of the facial–acoustic nerve during the operation and provide an intuitive basis for judging the tumor boundary. The subperineural resection technique may be conducive to improving the rate of total tumor resection and facial–acoustic nerve functional preservation in the surgical treatment of VSs.
Markers Associated With Tumor Recurrence in Patients With Breast Cancer Achieving a Pathologic Complete Response After Neoadjuvant Chemotherapy
Authors: Xie Li-Yun , Wang Kun , Chen Hai-Lu , Shi Yan-Xia , Zhang Yuan-Qi , Lin Hao-Yu , Liang Yuan-Ke , Xiao Ying-Sheng , Wu Zhi-Yong , Yuan Zhong-Yu , Qiu Si-Qi 
Published: April 2022

BackgroundPatients who achieve a tumor pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) have better outcomes than patients with residual tumor. However, tumors still recur in the pCR patients. Therefore, we aim to explore factors associated with tumor recurrence in this patient population.MethodsA total of 1,913 patients diagnosed with breast cancer between 1995 and 2020 and received NAC were included in this analysis. Clinicopathological data of the patients were retrospectively collected. We used Cox regression analysis to assess the associations of clinicopathological factors with patients’ outcome. Proteomic study of tumors was applied to identify differentially expressed proteins (DEPs) between tumors from the pCR patients with tumor recurrence and tumors from those without tumor recurrence. PPI network analysis of the corresponding genes of DEPs was used to identify the hub genes. The prognostic value of the corresponding genes of DEPs was evaluated using two online databases, Kaplan-Meier Plotter and bc-GenExMiner. The genes that were significantly associated with patients’ survival in both databases, as well as being identified as hub genes, were considered as potential prognostic markers for pCR patients. Publicly available data from Gene Expression Omnibus (GEO) was used to verify the prognostic value of the identified marker.ResultsAmong the 1,913 included patients, 420 had tumor pCR. The median follow-up for the pCR patients was 32.6 months (IQR, 16.3-55.5). Overall estimated 5-year risk of tumor recurrence for the pCR patients was 11%. Multivariable analysis showed that a higher pre-NAC clinical T stage and N stage were independent predictors for increased risk of tumor recurrence (hazard ratio [HR] 2.57, 95% confidence interval [CI] 1.01-6.51, P=0.047 for clinical T stage and HR 3.48, 95%CI 1.37-8.83, P=0.009 for clinical N stage). NAC regimens, the type of breast and axillary surgery, and adjuvant chemotherapy were not associated with tumor recurrence. Finally, aldehyde dehydrogenase (ALDH) 3A2 was identified by the proteomic study and was verified as a potential predictor for tumor recurrence in the pCR patients (with a median follow up of 3.78 years for dataset GSE32603 and 2.74 years for dataset GSE25066 from GEO, tumor recurrence rate: low versus high expression, 20.7% versus 4.5% [data from GSE32603]; 10.9% versus 0% [data from GSE25066]).ConclusionsClinical T stage, clinical N stage and tumor expression of ALDH3A2 were potential markers for predicting tumor recurrence in the pCR patients after NAC.
Multiphase Dual-Energy Spectral CT-Based Deep Learning Method for the Noninvasive Prediction of Head and Neck Lymph Nodes Metastasis in Patients With Papillary Thyroid Cancer
Authors: Jin Dan , Ni Xiaoqiong , Zhang Xiaodong , Yin Hongkun , Zhang Huiling , Xu Liang , Wang Rui , Fan Guohua 
Published: April 2022

PurposeTo develop deep learning (DL) models based on multiphase dual-energy spectral CT for predicting lymph nodes metastasis preoperatively and noninvasively in papillary thyroid cancer patients.MethodsA total of 293 lymph nodes from 78 papillary thyroid cancer patients who underwent dual-energy spectral CT before lymphadenectomy were enrolled in this retrospective study. The lymph nodes were randomly divided into a development set and an independent testing set following a 4:1 ratio. Four single-modality DL models based on CT-A model, CT-V model, Iodine-A model and Iodine-V model and a multichannel DL model incorporating all modalities (Combined model) were proposed for the prediction of lymph nodes metastasis. A CT-feature model was also built on the selected CT image features. The model performance was evaluated with respect to discrimination, calibration and clinical usefulness. In addition, the diagnostic performance of the Combined model was also compared with four radiologists in the independent test set.ResultsThe AUCs of the CT-A, CT-V, Iodine-A, Iodine-V and CT-feature models were 0.865, 0.849, 0.791, 0.785 and 0.746 in the development set and 0.830, 0.822, 0.744, 0.739 and 0.732 in the testing set. The Combined model had outperformed the other models and achieved the best performance with AUCs yielding 0.890 in the development set and 0.865 in the independent testing set. The Combined model showed good calibration, and the decision curve analysis demonstrated that the net benefit of the Combined model was higher than that of the other models across the majority of threshold probabilities. The Combined model also showed noninferior diagnostic capability compared with the senior radiologists and significantly outperformed the junior radiologists, and the interobserver agreement of junior radiologists was also improved after artificial intelligence assistance.ConclusionThe Combined model integrating both CT images and iodine maps of the arterial and venous phases showed good performance in predicting lymph nodes metastasis in papillary thyroid cancer patients, which could facilitate clinical decision-making.
Design, Synthesis, and Antitumor Activity of Erlotinib Derivatives
Authors: Mao Long-fei , Wang Zhen-Zhen , Wu Qiong , Chen Xiaojie , Yang Jian-Xue , Wang Xin , Li Yue-Ming 
Published: April 2022

Nineteen erlotinib derivatives bearing different 1,2,3-triazole moieties were designed, synthesized, and evaluated for their potential against different cancer cell lines. The structures of the synthesized compounds were confirmed via1H NMR, 13C NMR, and HR MS. Preliminary antitumor activity assay results suggested that some compounds showed remarkable inhibitory activity against different cancer cell lines including the corresponding drug-resistant ones. Among these compounds, 3d was the most promising one with an IC50 of 7.17 ± 0.73 μM (KYSE70TR), 7.91 ± 0.61 μM (KYSE410TR), 10.02 ± 0.75 μM (KYSE450TR), 5.76 ± 0.3 3 μM (H1650TR), and 2.38 ± 0.17 μM (HCC827GR). A preliminary mechanism study suggested that compound 3d suppressed cancer cell proliferation through the EGFR-TK pathway.
The Risk of Ventricular Dysrhythmia or Sudden Death in Patients Receiving Serotonin Reuptake Inhibitors With Methadone: A Population-Based Study
Authors: Antoniou Tony , McCormack Daniel , Tadrous Mina , Juurlink David N. , Gomes Tara 
Published: April 2022

Background: Methadone is associated with ventricular dysrhythmias and sudden death. Serotonin reuptake inhibitors (SRIs) may increase the risk of these events either by inhibiting metabolism of methadone’s proarrhythmic (S)-enantiomer, additive QT interval prolongation, or both. We sought to determine whether certain SRIs were associated with a higher risk of methadone-related ventricular dysrhythmias or sudden death.Methods: We conducted a nested case-control study of Ontario residents receiving methadone between April 1, 1996 and December 31, 2017. Cases, defined as patients who died of sudden cardiac death or were hospitalized with a ventricular dysrhythmia while on methadone, were matched with up to four controls who also received methadone on age, sex, and a disease risk score. We determined the odds ratio (OR) and p-value functions for the association between methadone-related cardiotoxicity and treatment with SRIs known to inhibit metabolism of (S)-methadone (paroxetine, fluvoxamine, sertraline) or prolong the QT interval (citalopram and escitalopram). Patients who were not treated with an SRI served as the reference group.Results: During the study period, we identified 626 cases and 2,299 matched controls. Following multivariable adjustment, we found that recent use of sertraline, fluvoxamine or paroxetine (adjusted OR 1.30; 95% confidence intervals [CI] 0.90–1.86) and citalopram and escitalopram (adjusted OR 1.26; 95% CI 0.97–1.63) were associated with small increases in the risk methadone-related cardiac toxicity, an assertion supported by the corresponding p-value functions.Interpretation: Certain SRIs may be associated with a small increase in cardiac toxicity in methadone-treated patients.
Suppressive Modulation of the Chick Forebrain Network for Imprinting by Thyroid Hormone: An in Vitro Study
Authors: Saheki Yuriko , Aoki Naoya , Homma Koichi J. , Matsushima Toshiya 
Published: April 2022

The thyroid hormone 3,5,3′-triiodothyronine (T3) is considered to act acutely in the chick forebrain because focal infusion of T3 to the intermediate medial mesopallium (IMM) causes 4 to 6-day-old hatchlings to become imprintable approximately 30 min after the infusion. To understand the mechanism of this acute T3 action, we examined synaptic responses of IMM neurons in slice preparations in vitro. Extracellular field potential responses to local electrical stimulation were pharmacologically dissociated to synaptic components mediated by AMPA and NMDA receptors, as well as GABA-A and -B receptors. Bath-applied T3 (20–40 μM) enhanced the positive peak amplitude of the field potential, which represented the GABA-A component. Bicuculline induced spontaneous epileptic bursts by NMDA receptor activation, and subsequent application of T3 suppressed the bursting frequency. Pretreatment of slices with T3 failed to influence the synaptic potentiation caused by tetanic stimulation. Intracellular whole-cell recording using a patch electrode confirmed the T3 actions on the GABA-A and NMDA components. T3 enhanced the GABA-A response and suppressed the NMDA plateau potential without changes in the resting membrane potential or the threshold of action potentials. Contrary to our initial expectation, T3 suppressed the synaptic drives of IMM neurons, and did not influence activity-dependent synaptic potentiation. Imprinting-associated T3 influx may act as an acute suppressor of the IMM network.
Maternal Sensitivity Modulates Child’s Parasympathetic Mode and Buffers Sympathetic Activity in a Free Play Situation
Authors: Köhler-Dauner Franziska , Roder Eva , Gulde Manuela , Mayer Inka , Fegert Jörg M. , Ziegenhain Ute , Waller Christiane 
Published: April 2022

BackgroundBehavioral and physiological (self-)regulation in early life is crucial for the understanding of childhood development and adjustment. The autonomic nervous system (ANS) is a main player in the regulative system and should therefore be modulated by the quality of interactive behavior of the caregiver. We experimentally investigated the ANS response of 18–36-month-old children in response to the quality of maternal behavior during a mother–child-interacting paradigm.MethodEighty mothers and their children came to our laboratory and took part in an experimental paradigm, consisting of three episodes: a resting phase (E1), a structured play phase (E2), and a free play situation (E3) between mothers and their child. Children’s and mother’s heart rate (HR), the sympathetic nervous system (SNS) activityviathe pre-ejection period (PEP) and the left ventricular ejection time (LVET), and the parasympathetic nervous system (PNS) activityviathe respiratory sinus arrhythmia (RSA) were continuously measured by an electrocardiogram. Maternal sensitivity of interactive behavior was assessed by using the Emotional Availability (EA) Scales.ResultsChildren of mothers with insensitive behavior had a significantly lower RSA at baseline, showed a lack of RSA withdrawal during structured and free play, and had shorter LVET across all episodes compared to children of sensitive mothers.ConclusionOur findings depict the influence of low-quality maternal interaction on the child’s ANS regulation, in calm and more stressful play situations. The overall higher SNS mode with impaired PNS reactivity may negatively influence child’s ANS homoeostasis, which may result in a long-term impact on mental and physical wellbeing. Further, the maternal sensitivity may function as a buffer for the stress response of their child. These results could serve as a basis for the development of appropriate psychoeducational programs for mothers of low sensitivity in their interaction with the child.
Evaluasi User Experience Sistem Informasi Akademik Mahasiswa pada Perguruan Tinggi Menggunakan User Experience Questionnaire
Authors: Henim Silvana Rasio , Sari Rika Perdana 
Published: April 2022

User experience menggambarkan pengalaman yang didapatkan oleh pengguna ketika menggunakan produk perangkat lunak. Fokus kepada kebutuhan dan emosi pengguna ketika menggunakan sebuah produk merupakan salah satu kunci keberhasilan sebuah perangkat lunak. Sebagai sebuah produk perangkat lunak, Sistem Informasi Akademik Mahasiswa memiliki peranan yang penting untuk meningkatkan pelayanan kepada mahasiswa di Perguruan Tinggi. Pengukuran user experience bertujuan untuk mengetahui pengalaman yang diperoleh pengguna ketika menggunakan Sistem Informasi Akademik Mahasiswa. Pengukuran dilakukan dengan menggunakan User Experience Questionnaire (UEQ) pada 179 responden mahasiswa aktif sebuah Perguruan Tinggi di Pekanbaru. Hasil yang diperoleh untuk setiap aspek UEQ adalah daya tarik 1,395, kejelasan 1,586, efisiensi 1,380, ketepatan 1,392, stimulasi 1.347 dan kebaruan 0,847. Nilai yang terendah adalah pada aspek kebaruan. Aspek kebaruan perlu menjadi perhatian karena monoton dan lazim yang memiliki nilai impresi negatif. Nilai yang terendah adalah pada aspek kebaruan. Aspek kebaruan perlu menjadi perhatian karena pengguna merasakan kebaruan yang monoton dan lazim sehingga memiliki nilai impresi negatif. Hasil dari penelitian ini dapat digunakan sebagai rekomendasi untuk perancangan user experience Sistem Informasi Akademik Mahasiswa yang baru.
PENERAPAN METODE SYSTEM USABILITY SCALE (SUS) PERANGKAT LUNAK DAFTAR HADIR DI PONDOK PESANTREN MIFTAHUL JANNAH BERBASIS WEBSITE
Authors: Sanjaya M. Rudi Sanjaya , Saputra Ariansyah , Kurniawan Dedy 
Published: April 2022

Abstrak
Perkembangan teknologi dari waktu ke waktu berkembang dengan cepat, oleh karena dengan teknologi mempermudah pekerjaaan salah satu dengan menggunakan perangkat lunak, di pesantren miftahul Jannah terletak di desa peninjauan Kec Peninjauan kabupaten OKU tepatnya di Sumatera Selatan belum ada perangkat lunak salah satunya perangkat lunak daftar hadir berbasis website. Adapun tujuan dari penelitian ini adalah merancang dan membangun perangkat lunak daftar hadir di sekolah pondok pesantren miftahul Jannah untuk guru, siswa dan siswi (santri dan santriwati) menggunakan penerapan metode SUS Adapun metode penelitian ini menggunakan observasi, interview, studi literatur, analisis kebutuhan, tahap perancangan, implementasi serta metode untuk pengujian menggunakan metode SUS (System Usability Scale), adapun hasil yang di dapatkan dari penelitian perangkat lunak ini menerapkan metode SUS (System Usability Scale), dimana hasil untuk guru menunjukkan nilai rata-rata hasil konversi SUS didapatkan hasilnya adalah 79,54 sedangkan untuk responden siswa (Santri atau Santriwati) menunjukkan rata-rata hasil konversi nilai menggunakan metode SUS hasilnya adalah 79,33 dimana hasil konversi metode sus dalam penelitian ini sudah diterima untuk penerapan perangkat lunak ini.

Kata Kunci : SUS, Sublime Text, Website.
Dialogando, pensando e aprendendo com a trajetória de uma pesquisadora
Authors: Beltrão Sposito Maria Encarnação , Araújo Gonçalves Luiz Antônio 
Published: April 2022

O que nasceu como uma tentativa de aproximar pesquisadores de diversas áreas, de mobilizar os membros do Conselho Editorial da SertãoCult na elaboração de um material que exprimisse a capacidade da editora em produzir obras com qualidade técnica e com relevância acadêmica, tornou-se um sucesso logo em sua primeira edição. Após o lançamento do volume Diálogos sobre a Ditadura, que reuniu alguns dos maiores pesquisadores sobre a temática no Brasil, a série Território Científico chega ao seu segundo volume elaborado a partir de uma parceria com os profissionais ligados ao Seminário da Rede de Pesquisadores sobre as Cidades Médias (ReCiMe). Eis a obra “Trajetórias de pesquisadores e os estudos das cidades médias em perspectiva”. É gratificante concluirmos mais esta contribuição para a comunidade científica, apresentando as trajetórias de algumas das maiores referências da Geografia Urbana brasileira, que no contexto da pandemia da Covid-19 ficaram tão fisicamente distantes, mas nunca tão próximos, unidos através da tecnologia, que permitiu a troca de experiências com colegas de diferentes regiões do país. Passados alguns meses da realização das entrevistas, finalmente a pandemia dá mostras de arrefecimento. O isolamento que tanto nos custou, começa a dar lugar a reencontros presenciais e estas entrevistas, mais do que um relato de experiências de pesquisa, passam a compor um registro histórico de como a crise sanitária afetou toda a nossa sociedade. Se a produção científica segue sendo alvo de constantes ataques e aqueles que se dedicam a ela ainda são encarados quase como inimigos do Estado, é mais do que pertinente, mas necessário que todos aqueles que acreditam na educação, na ciência, no conhecimento se unam e abracem projetos que busquem aproximar essa produção e o público em geral. Mais um livro se junta à nossa série, nos deixando ainda mais orgulhosos e empenhados em nossa defesa incondicional da ciência. Que venham os próximos volumes!
Aprendendo sobre as cidades médias e pequenas da Amazônia brasileira
Authors: Cordeiro da Trindade Júnior Saint-Clair , Rodrigues Lopes Francisco Clébio 
Published: April 2022

O que nasceu como uma tentativa de aproximar pesquisadores de diversas áreas, de mobilizar os membros do Conselho Editorial da SertãoCult na elaboração de um material que exprimisse a capacidade da editora em produzir obras com qualidade técnica e com relevância acadêmica, tornou-se um sucesso logo em sua primeira edição. Após o lançamento do volume Diálogos sobre a Ditadura, que reuniu alguns dos maiores pesquisadores sobre a temática no Brasil, a série Território Científico chega ao seu segundo volume elaborado a partir de uma parceria com os profissionais ligados ao Seminário da Rede de Pesquisadores sobre as Cidades Médias (ReCiMe). Eis a obra “Trajetórias de pesquisadores e os estudos das cidades médias em perspectiva”. É gratificante concluirmos mais esta contribuição para a comunidade científica, apresentando as trajetórias de algumas das maiores referências da Geografia Urbana brasileira, que no contexto da pandemia da Covid-19 ficaram tão fisicamente distantes, mas nunca tão próximos, unidos através da tecnologia, que permitiu a troca de experiências com colegas de diferentes regiões do país. Passados alguns meses da realização das entrevistas, finalmente a pandemia dá mostras de arrefecimento. O isolamento que tanto nos custou, começa a dar lugar a reencontros presenciais e estas entrevistas, mais do que um relato de experiências de pesquisa, passam a compor um registro histórico de como a crise sanitária afetou toda a nossa sociedade. Se a produção científica segue sendo alvo de constantes ataques e aqueles que se dedicam a ela ainda são encarados quase como inimigos do Estado, é mais do que pertinente, mas necessário que todos aqueles que acreditam na educação, na ciência, no conhecimento se unam e abracem projetos que busquem aproximar essa produção e o público em geral. Mais um livro se junta à nossa série, nos deixando ainda mais orgulhosos e empenhados em nossa defesa incondicional da ciência. Que venham os próximos volumes!