bluuebunny/crossref_metadata_2025_split huggingface dataset:
Baseline Electroencephalogram and Its Evolution after Activation of Dopaminergic System by Apomorphine in Middle-Aged 5XFAD Transgenic Mice, a Model of Alzheimer’s Disease
Authors: Vorobyov Vasily , Deev Alexander , Oganesyan Zoya , Sengpiel Frank , Ustyugov Aleksey A. 
Published: October 2022

Aging and Alzheimer’s disease (AD) are characterized by common pathological features associated with alterations in neuronal connections. These inevitably affect the functioning of specific brain areas and their interrelations, leading to questions about neuronal plasticity and the compensatory mechanisms associated with dopaminergic (DA) mediation. In this study on twelve-month-old freely moving 5XFAD-transgenic mice, serving as a model of AD, and their wild-type (WT) littermates, we analyze electroencephalograms (EEGs) from the motor cortex (MC), putamen (Pt) and the DA-producing ventral tegmental area (VTA) and substantia nigra (SN). Baseline EEGs in the transgenic mice were characterized by delta 2 activity enhancements in VTA and alpha attenuation in VTA and SN. In contrast to WT mice, which lack differences in EEG from these brain areas, 5XFAD mice showed theta–alpha attenuation and delta 2 and beta 2 enhancements in EEG from both VTA and SN vs. MC. In 5XFAD mice, a DA mimetic, apomorphine, lowered (vs. saline) the theta oscillations in Pt, VTA and SN and enhanced alpha in MC, Pt, VTA and beta 1 in all brain areas. These results and those obtained earlier in younger (six-month-old) mice suggest that the age-related characteristics of cerebral adaptive mechanisms affected by AD might be associated with modification of dopaminergic mediation in the mechanisms of intracerebral dynamic interrelations between different brain areas.
Meat Quality and Muscle Tissue Proteome of Crossbred Bulls Finished under Feedlot Using Wet Distiller Grains By-Product
Authors: Baldassini Welder , Gagaoua Mohammed , Santiago Bismarck , Rocha Leone , Torrecilhas Juliana , Torres Rodrigo , Curi Rogério , Neto Otávio Machado , Padilha Pedro , Santos Felipe , Lanna Dante Pazzanese , Chardulo Luis Artur 
Published: October 2022

Wet distiller grains (WDG) are a corn by-product rich in protein and fiber that can be used in feedlot diets. This study evaluated F1 Angus-Nellore bulls fed on a control diet vs. WDG (n = 25/treatment). After a period of 129 days on these feeds, the animals were slaughtered and Longissimus thoracis samples were collected for both a meat quality evaluation and gel-based proteomic analyses. A greater ribeye area (99.47 cm²) and higher carcass weight (333.6 kg) (p < 0.05) were observed in the WDG-finished cattle compared to the control (80.7 cm²; 306.3 kg). Furthermore, there were differences (p < 0.05) in the intramuscular fat between the WDG and control animals (IMF = 2.77 vs. 4.19%), which led to a significant decrease (p < 0.05) in saturated fatty acids (FA). However, no differences (p > 0.10) were observed in terms of tenderness, evaluated using Warner–Bratzler shear force (WBSF). The proteomic and bioinformatic analyses revealed substantial changes in the biological processes, molecular functions, and cellular components of the WDG-finished cattle compared to the control. Proteins related to a myriad of interconnected pathways, such as contractile and structural pathways, energy metabolism, oxidative stress and cell redox homeostasis, and transport and signaling. In this experiment, the use of WDG supplementation influenced the protein expression of several proteins, some of which are known biomarkers of beef quality (tenderness and color), as well as the protein–protein interactions that can act as the origins of increases in muscle growth and reductions in IMF deposition. However, despite the effects on the proteome, the tenderness, evaluated by WBSF, and fatty acid profile were not compromised by WDG supplementation.
Extracellular c-di-GMP Plays a Role in Biofilm Formation and Dispersion of Campylobacter jejuni
Authors: Elgamoudi Bassam A. , Starr Kirstie S. , Korolik Victoria 
Published: October 2022

Cyclic diguanosine monophosphate (c-diGMP) is a ubiquitous second messenger involved in the regulation of many signalling systems in bacteria, including motility and biofilm formation. Recently, it has been reported that c-di-GMP was detected in C. jejuni DRH212; however, the presence and the role of c-di-GMP in other C. jejuni strains are unknown. Here, we investigated extracellular c-di-GMP as an environmental signal that potentially triggers biofilm formation in C. jejuni NCTC 11168 using a crystal violet-based assay, motility-based plate assay, RT-PCR and confocal laser scanning microscopy (CLSM). We found that, in presence of extracellular c-di-GMP, the biofilm formation was significantly reduced (>50%) and biofilm dispersion enhanced (up to 60%) with no effect on growth. In addition, the presence of extracellular c-di-GMP promoted chemotactic motility, inhibited the adherence of C. jejuni NCTC 11168-O to Caco-2 cells and upregulated the expression of Cj1198 (luxS, encoding quarum sensing pathway component, autoinducer-2), as well as chemotaxis genes Cj0284c (cheA) and Cj0448c (tlp6). Unexpectedly, the expression of Cj0643 (cbrR), containing a GGDEF-like domain and recently identified as a potential diguanylate cyclase gene, required for the synthesis of c-di-GMP, was not affected. Our findings suggest that extracellular c-di-GMP could be involved in C. jejuni gene regulation, sensing and biofilm dispersion.
Lactobacillus paragasseri BBM171 Ameliorates Allergic Airway Inflammation Induced by Ovalbumin in Mice via Modulating the Th1/Th2 Balance
Authors: Cheng Shih-Hsuan , Yang Tzu-Ying , Hsu Chih-Chieh , Wei Yu-Hsuan , Wu Chien-Chen , Tsai Ying-Chieh 
Published: October 2022

Supplementation with specific probiotics has been shown to improve allergic airway symptoms. This study aimed to investigate immunomodulatory effects of a potential probiotic strain isolated from breast milk, Lactobacillus paragasseri BBM171 (BBM171), in an ovalbumin (OVA)-induced allergic mouse model. OVA-sensitized and OVA-challenged BALB/c mice were orally administered live or heat-inactivated BBM171 for 48 consecutive days. After the last allergen challenge, serum immunoglobulin (Ig) levels, inflammatory cell levels in the lungs, and cytokine levels in bronchoalveolar lavage fluid (BALF) were assessed. The results showed that oral administration of live or heat-inactivated BBM171 decreased serum levels of total IgE, OVA-specific IgE, and OVA-specific IgG1, while increasing OVA-specific IgG2a and reducing the extent of airway inflammation in OVA-induced allergic mice. In addition, both live and heat-inactivated BBM171 modulated the cytokine profile in BALF to a type 1 T helper (Th1) response. Furthermore, ex vivo experiments using OVA-induced allergic mouse splenocytes showed that both live and heat-inactivated BBM171 could regulate the Th1/Th2 balance, decrease the proinflammatory cytokine interleukin (IL)-17 level, and increase the anti-inflammatory cytokine IL-10 level. Taken together, these results suggest that oral administration of live or heat-inactivated BBM171 improved allergen-induced airway inflammation symptoms by modulating the host immune response toward Th1 dominance.
Alveolar cleft bone grafting at different age periods
Authors: Yakovlev S. V. , Topolnitsky O. Z. , Pershina M. A. , Shonicheva Yu. A. , Gurgenadze A. P. , Makeev A. V. , Beglaryan A. A. , Bakshi T. A. 
Published: October 2022

Relevance. Anatomical and functional disorders in congenital clefts may be various. Their severity depends on the cleft size and on the combination of a cleft lip with an alveolar cleft. Alveolar cleft bone grafting (ACBG) is one of the most important surgeries for patients with cleft lip and palate rehabilitation. The study aimed to analyze the results of alveolar cleft bone grafting in various age groups, summarizing the available data and supplementing them with our own experience.Materials and methods. In our clinic, 488 patients of different ages (from 4 to 18 years old), including patients with bilateral clefts, underwent ACBG.Results. The result analysis showed the time of surgery should depend not on the child's age but on the orthodontic preparation of the child for ACBG.Conclusion. The literature data and our experience allowed us to develop indications for ACBG at different ages
Theory and Applications in Biomedical Engineering after Discovering a New Human Organ “Interstitium”
Authors: Wang Johnson 
Published: October 2022

<p>Traditional Chinese Medicine (TCM) is based on the physiological concept that life is supported by the continuous and all-pervading flow of energy named Chee. This concept has a logic deficiency that has handicapped TCM from entry into modern sciences in spite of the fact that it has been in practice since 2700 BC. In March 2018, the “Interstitium” was formally reported as a newly discovered organ that pervades the entire human body. This author believed that Interstitium as reported could cure TCM’s logic deficiency, thus started a small research program in July. By latching onto Interstitium, and distilling and synthesizing TCM procedures to conform to modern sciences, we have transformed TCM to a modern empirical science. We have also formulated a theory of Chee to enable TCM to be a full-fledged Scientific TCM (STCM). The method and procedure employed in developing this theory are similar to those taken by Julius Stratton in formulating classical macroscopic electromagnetic theory discussed in his book of 1941. Potential biomedical applications for STCM are many, including mental illnesses, inflammation, allergy, and infectious diseases. Since reported results are preliminary and lack independent verification, global collaborative efforts, both technical and business, are earnestly solicited openly </p>
Paresthesia of the inferior alveolar nerve caused by periapical pathology: case report
Authors: Ismailov F. R. , Khabadze Z. S. 
Published: October 2022

Paresthesia in the chin area may not always be caused by a neurological condition. Sometimes persistent and prolonged treatment of the trigeminal nerve for neuralgia, does not have a positive result. One cause of mandibular numbness may be caused by compression on the mandibular canal by an odontogenic cyst.Aim. To demonstrate the clinical symptomatology and radiological signs of mandibular nerve damage in a 48-year-old patient who underwent re-treatment of the lower left seventh tooth in 2 visits with long-term clinical and radiological follow-up.
Working memory is updated by reallocation of resources from obsolete to new items
Authors: Taylor Robert , Tomić Ivan , Aagten-Murphy David , Bays Paul M. 
Published: October 2022

AbstractVisual working memory (VWM) resources are limited, placing constraints on how much visual information can be simultaneously retained. During visually guided activity, stored information can quickly become outdated, so updating mechanisms are needed to ensure the contents of memory remain relevant to current task goals. In particular, successful deallocation of resources from items that become obsolete is likely to be critical for maintaining the precision of those representations still in memory. The experiments in this study involved presenting two memory arrays of coloured disks in sequence. The appearance of the second array was a cue to replace, rehearse, or add a new colour to the colours in memory. We predicted that successful resource reallocation should result in comparable recall precision when an item was replaced or rehearsed, owing to the removal of pre-replacement features. In contrast, a failure to update WM should lead to comparable precision with a condition in which a new colour was added to memory. We identified a very small proportion (∼5%) of trials in which participants incorrectly reported a feature from the first array in place of its replacement in the second, which we interpreted as a failure to incorporate the information from the second display into memory. Once these trials were discounted, precision estimates were consistent with complete redistribution of resources in the case of updating a single item. We conclude that working memory can be efficiently updated when previous information becomes obsolete, but that this is a demanding active process that occasionally fails.
Quantification of the Cross-helicity Turbulent Cascade in Compressible MHD Simulations
Authors: Montagud-Camps Victor , Hellinger Petr , Verdini Andrea , Papini Emanuele , Franci Luca , Landi Simone 
Published: October 2022

Abstract
In plasma turbulence, energy and cross helicity are transferred across scales at a constant rate as a consequence of nonlinear interactions. In incompressible magnetohydrodynamics (MHD), the energy cascade rate of both quantities can be computed by means of the temporal evolution of second-order structure functions, known as Karman–Howarth–Monin (KHM) equations. In the present work, we derive the KHM equation to compute the energy cascade rate of cross helicity in compressible MHD. Using three-dimensional direct numerical simulations, we validate the equation and use it to measure the cross-helicity turbulence properties. Our results show a slower development of the cross-helicity cascade with respect to the energy one and the presence of inverse cascades of energy and cross helicity at large scales when in the presence of a strong mean field. We propose the relation of these phenomena with the longer duration of geomagnetic storms after the arrival of solar winds with large cross helicity and the observation of patchy inertial ranges displaying positive and negative cascade rates for certain solar wind intervals.
Discovery of Interstellar 2-Cyanoindene (2-C9H7CN) in GOTHAM Observations of TMC-1
Authors: Sita Madelyn L. , Changala P. Bryan , Xue Ci , Burkhardt Andrew M. , Shingledecker Christopher N. , Kelvin Lee Kin Long , Loomis Ryan A. , Momjian Emmanuel , Siebert Mark A. , Gupta Divita , Herbst Eric , Remijan Anthony J. , McCarthy Michael C. , Cooke Ilsa R. , McGuire Brett A. 
Published: October 2022

Abstract
We present laboratory rotational spectroscopy of five isomers of cyanoindene (2-, 4-, 5-, 6-, and 7-cyanoindene) using a cavity Fourier transform microwave spectrometer operating between 6 and 40 GHz. Based on these measurements, we report the detection of 2-cyanoindene (1H-indene-2-carbonitrile; 2-

C

9

H

7

CN

) in GOTHAM line survey observations of the dark molecular cloud TMC-1 using the Green Bank Telescope at centimeter wavelengths. Using a combination of Markov Chain Monte Carlo, spectral stacking, and matched filtering techniques, we find evidence for the presence of this molecule at the 6.3σ level. This provides the first direct observation of the ratio of a cyano-substituted polycyclic aromatic hydrocarbon to its pure hydrocarbon counterpart, in this case indene, in the same source. We discuss the possible formation chemistry of this species, including why we have only detected one of the isomers in TMC-1. We then examine the overall hydrocarbon:CN-substituted ratio across this and other simpler species, as well as compare to those ratios predicted by astrochemical models. We conclude that while astrochemical models are not yet sufficiently accurate to reproduce absolute abundances of these species, they do a good job at predicting the ratios of hydrocarbon:CN-substituted species, further solidifying -CN tagged species as excellent proxies for their fully symmetric counterparts.
A Lower Bound of Star Formation Activity in Ultra-high-redshift Galaxies Detected with JWST: Implications for Stellar Populations and Radiation Sources
Authors: Inayoshi Kohei , Harikane Yuichi , Inoue Akio K. , Li Wenxiu , Ho Luis C. 
Published: October 2022

Abstract
Early results of James Webb Space Telescope observations have delivered bright z ≳ 10 galaxy candidates in greater numbers than expected, enabling construction of rest-frame UV luminosity functions (LFs). The LFs contain key information on the galaxy assembly history, star formation activity, and stellar population of the distant universe. Given an upper bound of the total baryonic mass inflow rate to galaxies from their parent halos estimated from abundance matching, we derive a lower bound on the product of the star formation and UV photon production efficiency in galaxies at each redshift. This stringent constraint requires a high efficiency (≳10%–30%) converting gas into stars, assuming a normal stellar population with a Salpeter-like mass distribution. The efficiency is substantially higher than those of typical nearby galaxies, but is consistent with those seen in starburst galaxies and super-star clusters observed in the nearby universe. Alternatively, the star formation efficiency may be as low as a few percent, which is the average value for the entire galaxy population at z ≃ 6, if the stellar population is metal-free and drawn from a top-heavy mass distribution that produces more intense UV radiation. We discuss several other possible scenarios to achieve the constraint, for instance, energetic radiation produced from compact stellar remnants and quasars, and propose ways to distinguish the scenarios by forthcoming observations.
An Empirical Approach to Selecting the First Growing Black Hole Seeds with JWST/NIRCam
Authors: Goulding Andy D. , Greene Jenny E. 
Published: October 2022

Abstract
The James Webb Space Telescope (JWST) will have the sensitivity to detect early low-mass black holes (BHs) as they transition from “seeds” to supermassive BHs. Based on the JAGUAR mock catalog of galaxies, we present a clean color selection that takes advantage of the unique UV slope of accreting supermassive BHs with a relatively low mass and high accretion rates. We show that those galaxies hosting ∼106
M
⊙ BHs radiating at >10% of their Eddington luminosity separate in color space from inactive systems for a range of host stellar masses. Here we propose a set of 3-band, 2-color selection boxes (with 90% completeness; 90% purity; balanced purity/completeness) with JWST/NIRCam to identify the most promising growing BH candidates at z ∼ 7–10.
Observation and Modeling of the Solar Wind Turbulence Evolution in the Sub-Mercury Inner Heliosphere
Authors: Telloni Daniele , Adhikari Laxman , Zank Gary P. , Hadid Lina Z. , Sánchez-Cano Beatriz , Sorriso-Valvo Luca , Zhao Lingling , Panasenco Olga , Shi Chen , Velli Marco , Susino Roberto , Verscharen Daniel , Milillo Anna , Alberti Tommaso , Narita Yasuhito , Verdini Andrea , Grimani Catia , Bruno Roberto , D’Amicis Raffaella , Perrone Denise , Marino Raffaele , Carbone Francesco , Califano Francesco , Malara Francesco , Stawarz Julia E. , Laker Ronan , Liberatore Alessandro , Bale Stuart D. , Kasper Justin C. , Heyner Daniel , de Wit Thierry Dudok , Goetz Keith , Harvey Peter R. , MacDowall Robert J. , Malaspina David M. , Pulupa Marc , Case Anthony W. , Korreck Kelly E. , Larson Davin , Livi Roberto , Stevens Michael L. , Whittlesey Phyllis , Auster Hans-Ulrich , Richter Ingo 
Published: October 2022

Abstract
This letter exploits the radial alignment between the Parker Solar Probe and BepiColombo in late 2022 February, when both spacecraft were within Mercury’s orbit. This allows the study of the turbulent evolution, namely, the change in spectral and intermittency properties, of the same plasma parcel during its expansion from 0.11 to 0.33 au, a still unexplored region. The observational analysis of the solar wind turbulent features at the two different evolution stages is complemented by a theoretical description based on the turbulence transport model equations for nearly incompressible magnetohydrodynamics. The results provide strong evidence that the solar wind turbulence already undergoes significant evolution at distances less than 0.3 au from the Sun, which can be satisfactorily explained as due to evolving slab fluctuations. This work represents a step forward in understanding the processes that control the transition from weak to strong turbulence in the solar wind and in properly modeling the heliosphere.
Mesure, estimation et représentations de la Covid-19
Authors: Guichard Éric , Abry Patrice 
Published: October 2022

Comme nombre de chercheurs, nous avons mis nos savoirs au service de la lutte contre la Covid-19. Dès février 2020, nous avons produit des graphiques quotidiens afin de comparer l’évolution de la pandémie selon les pays. Nous avons aussi fédéré un réseau scientifique qui élaborait et documentait des analyses pertinentes. Ensuite, nous avons conçu un outil qui estime au mieux le taux de reproduction de la pandémie dans les pays du monde et dans les départements français, en n’utilisant que le nombre des infections quotidiennes observées dans chaque territoire. Disposant de données de qualité limitée, notre modèle s’est focalisé sur la correction des erreurs, via des méthodes dites de « problèmes inverses ». Bien qu’il ne permette d’estimer que le taux de reproduction du jour, notre outil permet une évaluation de tendance à court terme. Enfin, pour analyser au mieux l’évolution spatiale et temporelle de la pandémie, nous avons réalisé une carte animée et interactive intégrant la production de graphiques permettant la comparaison entre deux pays. Nous concluons cet article en abordant quelques pistes épistémologiques.
Some remarks on approximation in several complex variables
Authors: Falcó Javier , Gauthier Paul M. , Manolaki Myrto , Nestoridis Vassili 
Published: October 2022

AbstractIn Gauthier, Manolaki, and Nestoridis (2021, Advances in Mathematics 381, 107649), in order to correct a false Mergelyan-type statement given in Gamelin and Garnett (1969, Transactions of the American Mathematical Society 143, 187–200) on uniform approximation on compact sets K in
$\mathbb C^d$
, the authors introduced a natural function algebra
$A_D(K)$
which is smaller than the classical one
$A(K)$
. In the present paper, we investigate when these two algebras coincide and compare them with the classes of all plausibly approximable functions by polynomials or rational functions or functions holomorphic on open sets containing the compact set K. Finally, we introduce a notion of O-hull of K and strengthen known results.
A polynomial approximation result for free Herglotz–Agler functions
Authors: Kojin Kenta 
Published: October 2022

AbstractIn this paper, we prove a noncommutative (nc) analog of Schwarz lemma for the nc Schur–Agler class and prove that the regular nc Schur–Agler class and the regular free Herglotz–Agler class are homeomorphic. Moreover, we give a characterization of regular free Herglotz–Agler functions. As an application, we will show that any regular free Herglotz–Agler functions can uniformly be approximated by regular Herglotz–Agler free polynomials.