bluuebunny/crossref_metadata_2025_split huggingface dataset:
Legendre wavelet method for solving variable‐order nonlinear fractional optimal control problems with variable‐order fractional Bolza cost
Authors: Kumar Nitin , Mehra Mani 
Published: July 2022

AbstractThis paper deals with a numerical method for solving variable‐order fractional optimal control problem with a fractional Bolza cost composed as the aggregate of a standard Mayer cost and a fractional Lagrange cost given by a variable‐order Riemann–Liouville fractional integral. Using the integration by part formula and the calculus of variations, the necessary optimality conditions are derived in terms of two‐point variable‐order boundary value problem. Operational matrices of variable‐order right and left Riemann–Liouville integration are derived, and by using them, the two‐point boundary value problem is reduced into the system of algebraic equations. Additionally, the convergence analysis of the proposed method has been considered. Moreover, illustrative examples are given to demonstrate the applicability of the proposed method.
Rare complications of pessary use: A systematic review of case reports
Authors: Dabic Stefan , Sze Christina , Sansone Stephanie , Chughtai Bilal 
Published: July 2022

AbstractIntroductionPessaries are desirable for its overall safety profiles. Serious complications have been reported; however, there is little summative evidence. This systematic review aimed to consolidate all reported serious outcomes from pessaries usage to better identify and counsel patients who might be at higher risk of developing these adverse events.MethodsWe performed a systematic literature review using search terms such as ‘prolapse’, ‘stress urinary incontinence’ and ‘pessary or pessaries or pessarium’ on PubMed, Embase and CINAHL. A total of 36 articles were identified. Patient‐level data were extracted from case reports to further describe complications on an individual level.ResultsOverall median age of the patients was 82 years (range 62–98). The most frequent complications were vesicovaginal fistula (25%, n = 9/36), rectovaginal fistula (19%, n = 7/36), vaginal impaction (11%, n = 4/36) and vaginal evisceration of small bowel through vaginal vault (8%, n = 3/36). In the vesicovaginal fistula cohort, none of the patients had a history of radiation, and two had histories of total abdominal hysterectomy (22%). In the rectovaginal fistula cohort, one patient had a history of pelvic radiation for rectal squamous cell carcinoma, and another had a history of chronic steroid use for rheumatoid arthritis. No other risk factors were reported in the other groups. Ring and Gellhorn were the most represented pessary types among the studies, 16 (44%) and 12 (33%), respectively. No complications were reported with surgical and non‐surgical treatment of the complications.ConclusionPessaries are a reasonable and durable treatment for POP with exceedingly rare reports of severe adverse complications. The ideal candidate for pessary should have a good self‐care index. Studies to determine causative factors of the more serious adverse events are needed; however, this may be difficult given the long follow‐up that is required.
Die vierzügige Ganztagsgrundschule mit integrierter Zweifachsporthalle im Werksviertel in München
Authors: Wanninger Gerald , Ellinger Matthias 
Published: July 2022

AbstractZum Schuljahr 2021/2022 wurde im Rahmen der Münchner „Schulbauoffensive“ in Berg am Laim an der Haager Straße die neue vierzügige Grundschule mit integrierter Zweifachsporthalle fertiggestellt. Das Schulgebäude befindet sich direkt am Ostbahnhof im Werksviertel, dem Gelände der ehemaligen „Pfanni“‐Fabrik, einem der spannendsten aktuellen Stadtentwicklungsprojekte in München. Hier entsteht direkt neben dem neu geplanten Konzertsaal ein neues Stadtviertel mit Büros, Werkstätten, Restaurants, Hotels sowie ca. 1150 Wohnungen. Das Schulgrundstück hat eine Grundfläche von ca. 11.400 m2. Das viergeschossige Gebäude ist ein zeitgemäß gestalteter Einzelbaukörper, der sich in die vorhandene bzw. zukünftige städtebauliche Struktur eingliedert. Die vierzügige Ganztagsgrundschule wurde nach den Vorgaben des Münchener Lernhauskonzepts entworfen und bietet Platz für ca. 450 Schülerinnen und Schüler, eine Zweifachsporthalle sowie eine Wohnung für die Technische Hausverwaltung mit eigener, außen liegender Erschließung. In diesem Bericht wird auf die Lösungen im Rahmen der Tragwerksplanung eingegangen, welche die hohe Wirtschaftlichkeit des Gebäudeentwurfs bei gleichzeitig minimaler Versiegelung sicherstellten.
Marital status and survival in cancer patients: A systematic review and meta‐analysis
Authors: Krajc Kaja , Miroševič Špela , Sajovic Jakob , Klemenc Ketiš Zalika , Spiegel David , Drevenšek Gorazd , Drevenšek Martina 
Published: July 2022

AbstractBackgroundIn recent years, authors have repeatedly reported on the significance of social support in cancer survival. Although overall the studies appear to be convincing, little is known about which types of social support promote better survival rates, and which subgroups of cancer patients are more susceptible to the benefits of it. The aim of this study was to identify, organize, and examine studies reporting on the significance of social support in cancer survival.MethodsThe PubMed, CINAHL and EBSCO databases were searched using the keywords social support/marital status, cancer, and survival/mortality. Where possible we used a meta‐analytical approach, specifically a random effect model, in order to combine the results of the hazard ratios in studies from which this information could be obtained. When interpreting clinical relevance, we used the number needed to treat (NNT).ResultsBetter survival was observed in married patients when compared to unmarried (single, never‐married, divorced/separated, and widowed) in overall and cancer‐specific survival. Gender group differences showed that the association was statistically significant only in cancer‐specific survival when comparing divorced/separated male and female cancer patients (p < 0.001), thus confirming results from the previous meta‐analysis.ConclusionsBeing unmarried is associated with significantly worse overall and cancer‐specific survival. The most vulnerable group found in our study were divorced/separated men. The results of this review can motivate physicians, oncologists, and other healthcare professionals to be aware of the importance of patients' social support, especially in the identified sub‐group.
Anti‐Inflammatory Potential of Compounds Isolated from Tunisian Lichens Species
Authors: Mendili Mohamed , Khadhri Ayda , Mediouni‐Ben Jemâa Jouda , Andolfi Anna , Tufano Immacolata , Aschi‐Smiti Samira , DellaGreca Marina 
Published: July 2022

AbstractThe lichen's special symbiotic structure enables it to produce bioactive substances. They have historically been recognized for their aesthetic and medicinal benefits. Furthermore, in recent years, they have performed in various fields, including perfumery, dyeing, and pharmacology due to their rich secondary metabolites. From our study, four compounds were isolated from organic extracts of Parmotrema hypoleucinum, Roccella phycopsis, and Xanthoria parietina and identified by spectroscopic investigation as atranorin, (+)‐iso‐usnic acid, methyl orsellinate, and parietin, respectively. The anti‐inflammatory effects of lichens extracts, and pure compounds were evaluated on RAW 264.7 macrophages cells at different concentrations. At 25 μg/mL all treated samples did not show any effect on cell viability. Atranorin and (+)‐iso‐usnic acid showed an inhibitory effect on nitric oxide (NO) levels in lipopolysaccharide (LPS)‐stimulated macrophages. Nitric oxide (NO) production was measured using Griess reagent, atranorin and (+)‐iso‐usnic acid showed a high anti‐inflammatory potential (75.99 % and 57.27 % at 25 μg/mL). On the other hand, methyl orsellinate and the organic extracts of three lichens showed good anti‐inflammatory activity ranging from 29.16 % at 25 μg/mL to 86.91 % at 100 μg/mL.
Dental pulp stem cell secretome ameliorates d‐galactose induced accelerated aging in rat model
Authors: Kumar Ajay , Mahajan Aditi , Kumari Puja , Singh Jagjit , Raik Shalini , Saha Lekha , Pal Arnab , Medhi Bikash , Rattan Vidya , Bhattacharyya Shalmoli 
Published: July 2022

AbstractAdvancing age is associated with several diseases and disorders due to multiorgan atrophy. The increasing proportion of elderly humans demands the identification of means to counteract aging and age‐associated disorders. There is an increased depletion of stem cells in the aged organs, resulting in their inability to repair the damage and hence organ degeneration. Stem cell therapy has been implicated in counteracting aging and shown promise. However, the use of stem cells encounters several side effects and complications such as handling and storage of the cells for transplantation purpose. Stem cells secretome has proven to be of significant importance in a variety of disorders. In this study, we have shown that secretome derived from dental pulp stem cells (DPSCs) can reverse the age‐associated degeneration induced by chronic exposure to d‐galactose in a rat model. The secretome was able to increase muscle grip strength and animal activity. Secretome also improved the kidney function and hepatic biochemistry similar to healthy controls as evaluated by renal function test and Fourier‐transform infrared spectroscopy. We also showed that secretome reduced the levels of monoamine oxidase and acetylcholinesterase in the brain and liver, indicating aging reversal. Finally, proteomic profiling of DPSCs secretome revealed the presence of 13 proteins which have antiaging functions. Thus, our study provides first proof of concept that DPSCs secretome can render protection against d‐galactose induced accelerated aging.
COF‐based single Li+ solid electrolyte accelerates the ion diffusion and restrains dendrite growth in quasi‐solid‐state organic batteries
Authors: Zhao Genfu , Mei Zhiyuan , Duan Lingyan , An Qi , Yang Yongxin , Zhang Conghui , Tan Xiaoping , Guo Hong 
Published: July 2022

AbstractA solid‐state electrolyte (SSE), which is a solid ionic conductor and electron‐insulating material, is known to play a crucial role in adapting a lithium metal anode to a high‐capacity cathode in a solid‐state battery. Among the various SSEs, the single Li‐ion conductor has advantages in terms of enhancing the ion conductivity, eliminating interfacial side reactions, and broadening the electrochemical window. Covalent organic frameworks (COFs) are optimal platforms for achieving single Li‐ion conduction behavior because of well‐ordered one‐dimensional channels and precise chemical modification features. Herein, we study in depth three types of Li‐carboxylate COFs (denoted LiOOC‐COFn, n = 1, 2, and 3) as single Li‐ion conducting SSEs. Benefiting from well‐ordered directional ion channels, the single Li‐ion conductor LiOOC‐COF3 shows an exceptional ion conductivity of 1.36 × 10−5 S cm−1 at room temperature and a high transference number of 0.91. Moreover, it shows excellent electrochemical performance with long‐term cycling, high‐capacity output, and no dendrites in the quasi‐solid‐state organic battery, with the organic small molecule cyclohexanehexone (C6O6) as the cathode and the Li metal as the anode, and enables effectively avoiding dissolution of the organic electrode by the liquid electrolyte.
Insights into foundational therapies for heart failure with reduced ejection fraction
Authors: McMurray John J. V. , Docherty Kieran F. 
Published: July 2022

AbstractIn this review, we discuss what is meant by “foundational” therapy for patients with heart failure and reduced ejection fraction (HFrEF) and the evidence supporting the use of the five agents that comprise this group of drugs i.e., sacubitril/valsartan, a beta‐blocker, an aldosterone or mineralocorticoid receptor antagonist (MRA) and a sodium‐glucose cotransporter 2 (SGLT2) inhibitor. We review the conventional approach to sequencing these therapies in HFrEF and proposed new rapid sequencing strategies. We review a recent modelling study suggesting the optimal sequence of treatment includes a sodium‐glucose cotransporter 2 inhibition and an MRA as the first two therapies. Finally, we review the important opportunity offered by hospitalization for worsening heart failure to initiate and optimize foundational therapies in patients at high risk of early adverse outcomes.
Complex IgE sensitization patterns in ragweed allergic patients: Implications for diagnosis and specific immunotherapy
Authors: Buzan Maria‐Roxana , Zbîrcea Lauriana‐Eunice , Gattinger Pia , Babaev Elijahu , Stolz Frank , Valenta Rudolf , Păunescu Virgil , Panaitescu Carmen , Chen Kuan‐Wei 
Published: July 2022

AbstractBackgroundRagweed (Ambrosia artemisiifolia) is one of the most important allergen sources, worldwide, causing severe respiratory allergic reactions in late summer and fall, in sensitized patients. Amb a 1 has been considered as the most important allergen in ragweed but 12 ragweed pollen allergens are known. The aim of our study was to investigate IgE reactivity profiles of ragweed allergic patients and to associate them with clinical symptoms.MethodsIgE sensitization profiles from clinically well‐characterized ragweed allergic patients (n = 150) were analyzed using immunoblotted ragweed pollen extract. Immunoblot inhibition experiments were performed with two Amb a 1 isoforms and CCD markers and basophil activation experiments were performed with IgE serum before and after depletion of Amb a 1‐specific IgE.ResultsBy IgE‐immunoblotting 19 different IgE reactivity patterns with and without Amb a 1‐sensitization were found. The majority of patients (>95%) suffered from rhino‐conjunctivitis, around 60% reported asthma‐like symptoms and about 25% had skin reactions. Patients with complex IgE sensitization profiles tended to have more clinical symptoms. Serum with and without Amb a 1‐specific IgE induced basophil activation.ConclusionsRagweed pollen allergic patients exhibit complex IgE reactivity profiles to ragweed allergens including Amb a 1 isoforms and cross‐reactive carbohydrates indicating the importance of Amb a 1 isoforms and additional allergens for diagnosis and allergen‐specific immunotherapy of ragweed allergy.
Recurrent vincristine‐associated fever in a child with Wilms tumor
Authors: Al‐Antary Eman T. , Ramiz Sarah 
Published: July 2022

AbstractBackgroundFever is a common complaint among children with an underlying oncologic diagnosis, especially during chemotherapy courses and periods of neutropenia. Chemotherapy‐induced fever is well described in relation to specific chemotherapy agents. However, fever induced by vincristine (VCR) has only been rarely reported.CaseWe describe a case of a 5‐year‐old female with stage III Wilms tumor who had recurrent VCR‐associated fever that was controlled with prophylactic dexamethasone and acetaminophen.ConclusionIn patients developing recurrent fever following chemotherapy with VCR, febrile allergic reaction and prophylactic treatment should be considered after exhaustion of appropriate investigations.
Fast‐Charging Strategies for Lithium‐Ion Batteries: Advances and Perspectives
Authors: Zhao Jingteng , Song Congying , Li Guoxing 
Published: July 2022

AbstractRapid development of high‐energy‐density lithium‐ion batteries (LIBs) enables the sufficient driving range of electric vehicles (EVs). However, the slow charging speed restricts the popularization of EVs. Commitment to fast‐charging research is considered to be the key to advance the EVs strategy. This Review discusses the kinetic factors limiting the fast‐charging capability at the material aspects, and summarizes the recent research strategies to achieve fast‐charging performance of high‐energy‐density LIBs through electrode engineering, electrolyte design, and interface optimization. The increasingly important role of computational tools and advanced characterization techniques in fundamentally understanding the failure mechanism of LIBs is emphasized, and the analysis of the thermal runaway problem in the fast‐charging process and the corresponding thermal optimization scheme is also involved to give the guidance for the more rational battery design. In view of these factors and strategies, some future perspectives for realizing high‐performance fast‐charging LIBs are proposed, which are expected to facilitate the large‐scale application of fast‐charging LIBs in EVs.
Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
Authors: Shi Qiang , Arefin Ayesha , Ren Lijun , Papineau Katy S. , Barnette Dustyn A. , Schnackenberg Laura K. , Hawes Jessica J. , Avigan Mark , Mendrick Donna L. , Ewart Lorna , Ronxhi Janey 
Published: July 2022

AbstractDrug‐induced liver injury (DILI) is a significant public health issue, but standard animal tests and clinical trials sometimes fail to predict DILI due to species differences and the relatively low number of human subjects involved in preapproval studies of a new drug, respectively. In vitro models have long been used to aid DILI prediction, with primary human hepatocytes (PHHs) being generally considered the gold standard. However, despite many efforts and decades of work, traditional culture methods have been unsuccessful in either fully preserving essential liver functions after isolation of PHHs or in emulating interactions between PHHs and hepatic nonparenchymal cells (NPCs), both of which are essential for the development of DILI under in vivo conditions. Recently, various liver‐on‐a‐chip (Liver‐Chip) systems have been developed to co‐culture hepatocytes and NPCs in a three‐dimensional environment on microfluidic channels, enabling better maintenance of primary liver cells and thus improved DILI prediction. The Emulate® Liver‐Chip is a commercially available system that can recapitulate some in vivo DILI responses associated with certain compounds whose liver safety profile cannot be accurately evaluated using conventional approaches involving PHHs or animal models due to a lack of innate immune responses or species‐dependent toxicity, respectively. Here, we describe detailed procedures for the use of Emulate® Liver‐Chips for co‐culturing PHHs and NPCs for the purpose of DILI evaluation. First, we describe the procedures for preparing the Liver‐Chip. We then outline the steps needed for sequential seeding of PHHs and NPCs in the prepared Liver‐Chips. Lastly, we provide a protocol for utilizing cells maintained in perfusion culture in the Liver‐Chips to evaluate DILI, using acetaminophen as an example. In all, use of this system and the procedures described here allow better preservation of the functions of human primary liver cells, resulting in an improved in vitro model for DILI assessment. © 2022 Wiley Periodicals LLC. This article has been contributed to by US Government employees and their work is in the public domain in the USA.Basic Protocol 1: Liver‐Chip preparationBasic Protocol 2: Seeding primary human hepatocytes and nonparenchymal cells on Liver‐ChipsBasic Protocol 3: Perfusion culture for the study of acetaminophen‐induced liver injury
Exploring Manually Curated Annotations of Intrinsically Disordered Proteins with DisProt
Authors: Quaglia Federica , Hatos András , Salladini Edoardo , Piovesan Damiano , Tosatto Silvio C. E. 
Published: July 2022

AbstractDisProt is the major repository of manually curated data for intrinsically disordered proteins collected from the literature. Although lacking a stable three‐dimensional structure under physiological conditions, intrinsically disordered proteins carry out a plethora of biological functions, some of them directly arising from their flexible nature. A growing number of scientific studies have been published during the last few decades to shed light on their unstructured state, their binding modes, and their functions. DisProt makes use of a team of expert biocurators to provide up‐to‐date annotations of intrinsically disordered proteins from the literature, making them available to the scientific community. Here we present a comprehensive description on how to use DisProt in different contexts and provide a detailed explanation of how to explore and interpret manually curated annotations of intrinsically disordered proteins. We describe how to search DisProt annotations, both using the web interface and the API for programmatic access. Finally, we explain how to visualize and interpret a DisProt entry, the SARS‐CoV‐2 Nucleoprotein, characterized by the presence of unstructured N‐terminal and C‐terminal regions and a flexible linker. © 2022 The Authors. Current Protocols published by Wiley Periodicals LLC.Basic Protocol 1: Performing a search in DisProtSupport Protocol 1: Downloading optionsSupport Protocol 2: Programmatic access with DisProt REST APIBasic Protocol 2: Exploring the DisProt Ontology pageBasic Protocol 3: Visualizing and interpreting DisProt entries–the SARS‐CoV‐2 Nucleoprotein use case
Environmental, social and governance, corporate social responsibility, and stock returns: What are the short‐ and long‐Run relationships?
Authors: Feng Gen‐Fu , Long Han , Wang Hai‐Jie , Chang Chun‐Ping 
Published: July 2022

AbstractWhat are the relationships between corporate environmental, social, and governance (ESG), corporate social responsibility (CSR), and stock returns? Existing research has affirmed the impact of ESG or CSR on stock returns, but the discussion on the cointegration relationship among these three variables is still insufficient. Therefore, we use panel data of ESG ratings, CSR scores, and annual stock returns of 684 Chinese‐listed companies from 2011 to 2020 to verify the relationship between the variables through panel CADF and Westerlund tests. Meanwhile, we use PMG estimation to find that, in the long run, CSR significantly promotes the improvement of corporate stock returns, but ESG hurts the stock returns of most corporates. Further research proves that the impact of ESG on stock returns closely relates to corporate profitability. Our findings provide valuable policy implications for both developing and semi‐efficient market countries to help them improve their ESG and CSR performance.
Energy hole mitigation through optimized cluster head selection and strategic routing in Internet of Underwater Things
Authors: Gupta Swati , Singh Niraj Pratap 
Published: July 2022

SummaryInternet of Underwater Things (IoUT) comprises various resource‐constrained sensor nodes; therefore, the routing followed in acoustic medium underwater should be energy efficient to preserve their energies. Due to large area covered in the scenarios of underwater, the multi‐hop communication leads to energy hole problem. Therefore, Energy hole mitigation through Optimized Cluster Head (CH) selection and Strategic Routing (EOCSR) in IoUT is proposed in this paper. The proposed work not only optimizes CH selection using Tunicate Swarm Algorithm but also incorporates strategic routing to address energy hole problem. The simulation results show that EOCSR improves stability and lifetime of network by 16.8% and 17.7%, as compared with recently proposed Moth Flame Optimization‐based routing method.