bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parameter optimization of rubber cylinder of expansion liner hanger based on numerical simulation
Authors: Chen Yong , Liu Xin , Yi Hao , He Chuan , Xiao Guoping , Tan Jinjin , Wu Haochen , Su Anqiao 
Published: March 2022

AbstractThe expansion liner hanger has great advantages over the traditional slip liner hanger. Therefore, scholars at home and abroad have carried out extensive research on the expansion liner hanger, but there are few researches on the optimization design of the rubber cylinder of the expansion liner hanger. How to select the size and material of the rubber cylinder is very important to the suspension performance of the expansion liner hanger. Based on the Ø245 mm × Ø178 mm expansion liner hanger as the research object, the condition of the changes under the wall thickness and friction coefficient, using the finite element analysis software of rubber cylinder elongation rate, stress conditions are numerically simulated. The results show that when the wall thickness of the rubber cylinder is t = 1.5 mm, the elongation rate of the rubber cylinder is 2.14 mm, and then the elongation rate of the rubber cylinder increases rapidly with the increase of the wall thickness, and the growth of elongation rate slows down when the wall thickness is t ≥ 3.0 mm. The contact stress of the inner and outer walls of the rubber cylinder increases with the increase of the wall thickness, and the contact stress of the inner wall of the rubber cylinder fluctuates, and the fluctuation tends to be gentle when t ≥ 2.5 mm, and the residual stress of the rubber cylinder is uniformly distributed when t ≥ 2.5 mm. When different friction coefficients (0.05, 0.1, 0.15, 0.2, 0.25, 0.3) were taken between the rubber cylinder and the outer casing, the elongation rate of the rubber cylinder was negatively correlated with the friction coefficient, and the average contact stress on the wall was positively correlated with the friction coefficient. The results of this paper provide guidance for the design and material optimization of the rubber cylinder in the expansion liner hanger.
Falling Insulin Requirement in Pregnant Women With Diabetes Delivering Preterm: Prevalence, Predictors, and Consequences
Authors: Søholm Julie C , Do Nicoline C , Vestgaard Marianne , Ásbjörnsdóttir Björg , Nørgaard Sidse K , Pedersen Berit W , Storgaard Lone , Nielsen Birgitte B , Holmager Pernille , Ringholm Lene , Damm Peter , Mathiesen Elisabeth R 
Published: March 2022

Abstract

Context
Falling insulin requirements often lead to considerations of whether a pregnancy can continue safely or if delivery is indicated.

Objective
To evaluate prevalence and predictors of falling insulin requirements in pregnant women with preexisting diabetes delivering preterm and to explore the relationship to fetal asphyxia and neonatal morbidity.

Methods
A prospective cohort study of 101 consecutive singleton pregnant women with preexisting diabetes delivering preterm &lt; 37 weeks (68 type 1 and 33 type 2 diabetes) where the prevalence of falling insulin requirements (≥20%) before delivery was recorded.

Results
In total, 27% (27/101) experienced falling insulin requirements of median 30% (interquartile range 24-40) before delivery. In all women with type 1 diabetes, the prevalence was 37% (25/68), whereas it was 43% (24/56) in those with indicated preterm delivery and 6% (2/33) among women with type 2 diabetes. In women with type 1 diabetes and indicated preterm delivery, falling insulin requirements were first identified at 34 + 5 (33 + 6-35 + 4) weeks + days and delivery occurred 3 (1-9) days later. Gestational age at delivery, prevalence of suspected fetal asphyxia, and neonatal morbidity were similar in women with and without falling insulin requirements. Neither glycemic control, nausea, or preeclampsia was associated with falling insulin requirement.

Conclusion
Falling insulin requirements often preceded preterm delivery in women with type 1 diabetes, foremost when preterm delivery was indicated, but was not related to fetal asphyxia or neonatal morbidity. Whether falling insulin requirements in late pregnancy are a warning sign of placental insufficiency or mainly reflects variations in normal physiology needs further investigation.
Acute Deletion of the FOXO1-dependent Hepatokine FGF21 Does not Alter Basal Glucose Homeostasis or Lipolysis in Mice
Authors: Sostre-Colón Jaimarie , Gavin Matthew J , Santoleri Dominic , Titchenell Paul M 
Published: March 2022

Abstract
The hepatic transcription factor forkhead box O1 (FOXO1) is a critical regulator of hepatic and systemic insulin sensitivity. Previous work by our group and others demonstrated that genetic inhibition of FOXO1 improves insulin sensitivity both in genetic and dietary mouse models of metabolic disease. Mechanistically, this is due in part to cell nonautonomous control of adipose tissue insulin sensitivity. However, the mechanisms mediating this liver-adipose tissue crosstalk remain ill defined. One candidate hepatokine controlled by hepatic FOXO1 is fibroblast growth factor 21 (FGF21). Preclinical and clinical studies have explored the potential of pharmacological FGF21 as an antiobesity and antidiabetic therapy. In this manuscript, we performed acute loss-of-function experiments to determine the role of hepatocyte-derived FGF21 in glucose homeostasis and insulin tolerance both in control and mice lacking hepatic insulin signaling. Surprisingly, acute deletion of FGF21 did not alter glucose tolerance, insulin tolerance, or adipocyte lipolysis in either liver-specific FGF21KO mice or mice lacking hepatic AKT-FOXO1-FGF21, suggesting a permissive role for endogenous FGF21 in the regulation of systemic glucose homeostasis and insulin tolerance in mice. In addition, these data indicate that liver FOXO1 controls glucose homeostasis independently of liver-derived FGF21.
A Brief History ofO!
Authors: Sadowski Witold 
Published: March 2022

AbstractIn the poetry of many nations, the interjection O! is a marker of poeticalness, a marker that contributes to the factors distinguishing poetry from colloquial speech. O! is treated not so much as an expression derived from the language in which a given poem was written (i.e., English, Italian, Polish, etc.) as a common lexeme within an international poetic language. In different countries, the interjection O! is understood in similar ways and does not require translation, even if the other parts of the poem are rendered in distinct languages. Despite the importance of the interjection in world literature, research into the semantics of O! has been limited in scope. The aim of this article is to trace the main stages of development that O! has undergone in European poetry from antiquity until the present day. The article initially discusses the semantic variants of the interjection in ancient Greek and Latin poetry. These derive from two functions of O!, functions that are described within the context of the Bakhtinian concepts of the addressee and superaddressee. Subsequently, the process in which the autonomy of this lexeme was shaped with regard to vernacular languages is considered. The examples illustrating this process have been taken from Bulgarian, English, French, German, Italian, Occitan, and Polish poetry.
Narrative Forms of Adaptation, Retreat, and Mitigation in Richard Ford'sLet Me Be Frank with You
Authors: Ameel Lieven 
Published: March 2022

AbstractThis article examines narrative engagement with strange weather and rising waters in Richard Ford's Let Me Be Frank with You (2014). It applies three terms from climate policy—adaptation, retreat, and mitigation—as heuristic concepts to approach the formal responses in the novel to a catastrophic event, Hurricane Sandy, while also considering the broader implications for the interplay between narrative form and radical climate change. The focus is on narrative forms such as catalogs, gaps in language and in the storyworld, and plotted instances of compassion. By drawing from environmental policy terms, this article suggests an analogy between how literary fiction functions and how human populations are described as behaving in the language of policy. Literature is adapting in formal terms to a changing climate; it is retreating from the effects of climate disruption, by way of a diluted language; and it is trying to find ways to soften and mitigate those effects—with mitigation approached in its first, now largely obsolete meaning of the word, as compassion. Exploring such analogies, this article emphasizes literary form's participation in a broader discursive and material meshwork of human relationships with the transforming environment, in dialogue with science and policy communications.
The cell polarity determinant Dlg1 facilitates epithelial invagination by promoting tissue-scale mechanical coordination
Authors: Fuentes Melisa A. , He Bing 
Published: March 2022

ABSTRACT
Epithelial folding mediated by apical constriction serves as a fundamental mechanism to convert flat epithelial sheets into multilayered structures. It remains unknown whether additional mechanical inputs are required for apical constriction-mediated folding. Using Drosophila mesoderm invagination as a model, we identified an important role for the non-constricting, lateral mesodermal cells adjacent to the constriction domain (‘flanking cells’) in facilitating epithelial folding. We found that depletion of the basolateral determinant Dlg1 disrupts the transition between apical constriction and invagination without affecting the rate of apical constriction. Strikingly, the observed delay in invagination is associated with ineffective apical myosin contractions in the flanking cells that lead to overstretching of their apical domain. The defects in the flanking cells impede ventral-directed movement of the lateral ectoderm, suggesting reduced mechanical coupling between tissues. Specifically disrupting the flanking cells in wild-type embryos by laser ablation or optogenetic depletion of cortical actin is sufficient to delay the apical constriction-to-invagination transition. Our findings indicate that effective mesoderm invagination requires intact flanking cells and suggest a role for tissue-scale mechanical coupling during epithelial folding.
COVID-19 vaccination hesitancy among Iraqi general population between beliefs and barriers: An observational study
Authors: Shareef Laith G. , Fawzi Al-Hussainy Ali , Majeed Hameed Sajid 
Published: March 2022

Background: Vaccine apprehension poses a serious threat to global health. While there has been a tremendous global effort to create a vaccine against coronavirus disease 2019 (COVID-19), little is known about its reception in Iraq. Therefore, we sought to examine COVID-19 vaccine acceptance, hesitation, and related elements in the Iraqi population. Methods: Between the 19th of May and the 22nd of September 2021, a descriptive, cross-sectional web-based survey was conducted employing a quantitative approach. Respondents from both sexes aged 18 years and above who live in Iraq and agreed to participate were included. An anonymized online structured questionnaire was designed based on data from prior research on vaccine hesitation in general, and COVID-19 vaccination reluctance specifically. Results: A total of 1221 eligible participants from various regions in Iraq actively participated in the short web-based questionnaire. The overall acceptance rate of the COVID-19 vaccine was 56.2%, with a greater acceptance rate among younger male participants (p<0.05). Marital status had no significant association (p=0.834). Urbanization influenced the acceptance rate significantly (p=0.002). The barriers to receiving the COVID-19 vaccine were exemplified by the vaccine not being evaluated for a sufficient period in 51.4% of the responses, as well as concerns about future side effects in 76.6% of the responses and a lack of efficacy in 55.7% of the responses. The Pfizer-BioNTech vaccine received 39.6% preference and participants confidence, followed by the Oxford/AstraZeneca vaccine at 18.1% and the Sinopharm vaccine at 14.6%. Conclusions: COVID-19 vaccination apprehension was discovered in almost half of the study population. Lack of understanding about vaccination eligibility, anxiety about adverse events and vaccine efficacy, and distrust in the government were independently predictive of vaccine hesitation.
Health literacy and behaviors influencing blood sugar level control among type 2 diabetes patients in primary care units, Thailand: A cross-sectional study
Authors: Singsalasang Atthawit , Nguanjairak Rachanon , Salawonglak Tongtip 
Published: March 2022

Background: Type 2 Diabetes Mellitus (T2DM) remains a significant cause of death globally. In addition, T2DM is among the top five chronic diseases which leads to mortality in the Thai population. Patients with T2DM need a wide self-management protocol. However, patients with low health literacy experience difficulty in recognizing health-related information and have difficulties in expressing their status to health care providers, resulting in poor self-management which results in worsening of the health condition. This study aimed to identify the health literacy among patients with type 2 diabetes to determine its association between factors with blood sugar level control in the patients who are treated in primary care units. Methods: A total of 605 subjects were randomly selected from four districts of Nakhon Ratchasima Province, Northeastern Thailand. Data were collected using a structured questionnaire and a review of their charts. A descriptive statistical analysis was used to describe characteristics of the subjects. In addition, multiple logistic regression was used for the association to estimate effect sizes in terms of an odds ratio with the 95% confidence interval. Results: Of the total 605 respondents, 90.90% of the subjects had a sufficient level of health literacy about diabetes. The present study found the subjects who had sufficient health literacy were significantly associated with blood sugar level control (Adjusted Odds Ratio, (AOR)=2.27; 95% CI: 1.10-4.74; p =0.026). A strongly significant association with blood sugar level control was found with diet behaviors (AOR = 9.71; 95% CI: 5.98-15.77; p<0.001) and exercise behaviors (AOR = 14.50; 95% CI: 8.66-24.27; p<0.001). Conclusions: Health literacy on the changing health related behaviors among the T2DM patients is significantly associated with controlling blood sugar level. Hence, health practitioners should enhance the health literacy on self-care among T2DM patients which will help to control T2DM in an effective manner.
Price Discrimination with Fairness Constraints
Authors: Cohen Maxime C. , Elmachtoub Adam N. , Lei Xiao 
Published: March 2022

Price discrimination strategies, which offer different prices to customers based on differences in their valuations, have become common practice. Although it allows sellers to increase their profits, it also raises several concerns in terms of fairness (e.g., by charging higher prices (or denying access) to protected minorities in case they have higher (or lower) valuations than the general population). This topic has received extensive attention from media, industry, and regulatory agencies. In this paper, we consider the problem of setting prices for different groups under fairness constraints. We first propose four definitions: fairness in price, demand, consumer surplus, and no-purchase valuation. We prove that satisfying more than one of these fairness constraints is impossible even under simple settings. We then analyze the pricing strategy of a profit-maximizing seller and the impact of imposing fairness on the seller’s profit, consumer surplus, and social welfare. Under a linear demand model, we find that imposing a small amount of price fairness increases social welfare, whereas too much price fairness may result in a lower welfare relative to imposing no fairness. On the other hand, imposing fairness in demand or consumer surplus always decreases social welfare. Finally, no-purchase valuation fairness always increases social welfare. We observe similar patterns under several extensions and for other common demand models numerically. Our results and insights provide a first step in understanding the impact of imposing fairness in the context of discriminatory pricing. This paper was accepted by Jayashankar Swaminathan, operations management. Funding: A. N. Elmachtoub was supported by the Division of Civil, Mechanical and Manufacturing Innovation [Grants 1763000 and 1944428]. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2022.4317 .
Return to sport post-knee arthroplasty
Authors: Lester David , Barber Colby , Sowers Christopher B. , Cyrus John W. , Vap Alexander R. , Golladay Gregory J. , Patel Nirav K. 
Published: March 2022

Aims Return to sport following undergoing total (TKA) and unicompartmental knee arthroplasty (UKA) has been researched with meta-analyses and systematic reviews of varying quality. The aim of this study is to create an umbrella review to consolidate the data into consensus guidelines for returning to sports following TKA and UKA. Methods Systematic reviews and meta-analyses written between 2010 and 2020 were systematically searched. Studies were independently screened by two reviewers and methodology quality was assessed. Variables for analysis included objective classification of which sports are safe to participate in postoperatively, time to return to sport, prognostic indicators of returning, and reasons patients do not. Results A total of 410 articles were found, including 58 duplicates. Seven articles meeting inclusion criteria reported that 34% to 100% of patients who underwent TKA or UKA were able to return to sports at 13 weeks and 12 weeks respectively, with UKA patients more likely to do so. Prior experience with the sport was the most significant prognostic indicator for return. These patients were likely to participate in low-impact sports, particularly walking, cycling, golf, and swimming. Moderate-impact sport participation, such as doubles tennis and skiing, may be considered on a case-by-case basis considering the patient’s prior experience. There is insufficient long-term data on the risks to return to high-impact sport, such as decreased implant survivorship. Conclusion There is a consensus that patients can return to low-impact sports following TKA or UKA. Return to moderate-impact sport was dependent on a case-by-case basis, with emphasis on the patient’s prior experience in the sport. Return to high-impact sports was not supported. Patients undergoing UKA return to sport one week sooner and with more success than TKA. Future studies are needed to assess long-term outcomes following return to high-impact sports to establish evidence-based recommendations. This review summarizes all available data for the most up-to-date and evidence-based guidelines for returning to sport following TKA and UKA to replace guidelines based on subjective physician survey data. Cite this article: Bone Jt Open 2022;3(3):245–251.
FDTD Simulations of Modulated Metasurfaces with Arbitrarily Shaped Meta-atoms by Surface Impedance Boundary Condition
Authors: Hu Yanmeng , Zhou Quanen , Fang Xinyu , Li Mengmeng 
Published: March 2022

In this paper, we propose a reduced-complexity finite difference time domain (FDTD) simulations of modulated metasurfaces with arbitrary unit cells. The three dimensional (3D) physical structure of the metasurface is substituted by a spatially varying surface impedance boundary condition (IBC) in the simulation; as the mesh size is not dictated by sub-wavelength details, considerable advantage in space- and time-step is achieved. The local parameters of the IBC are obtained by numerical simulation of the individual unit cells of the physical structure, in a periodic environment approximation, in the frequency domain. As the FDTD requires an appropriate time domain impulse-response, the latter is obtained by broad-band frequency simulations, and vector fitting to an analytic realizable time response. The approach is tested on metasurface structures with complex unit cells and extending over 10 ××10 wavelengths, using a standard PC with 64GB RAM.
Access to domestic violence advocacy by race, ethnicity and gender: The impact of a digital warm handoff from the emergency department
Authors: Brignone Laura , Gomez Anu Manchikanti 
Published: March 2022

BackgroundRacial/ethnic minority survivors of domestic violence (DV) referred from emergency departments (EDs) face barriers connecting with advocacy services due to systemic inequities. This study assesses the impact of Domestic Violence Report and Referral (DVRR), a digital mandatory reporting compliance system with integrated direct-to-advocacy referrals sent with patient consent, on survivors’ likelihood of receiving advocacy by race/ethnicity and gender.MethodsWe assessed ED charts between 2014–2018 in an urban, Level 1 trauma center for DV-related positive screening, chief concern, or documentation in medical/social work notes. We matched these visits by name to local DV advocacy agency records. Using logistic regression, we assessed survivor odds of reaching advocacy by DVRR receipt, race/ethnicity and gender. We used predicted probabilities to identify between-group differences in advocacy services received.ResultsOf the 1366 visits, 740 received the DVRR intervention; 323 received advocacy services Without DVRR, compared to white, female survivors (n = 87), male survivors (n = 132) had 0.20 (95% CI: 0.07–0.56) times the odds of reaching advocacy compared to female survivors; Latinx survivors (n = 136) had 2.53 (95% CI: 1.58–4.07) times the odds of reaching advocacy compared to white survivors. With DVRR, the odds and predicted probabilities of reaching advocacy increased significantly for all survivors. White, female survivors (n = 74) who received DVRR experienced 2.60 (95% CI: 1.66–4.07) times the odds of connecting with advocacy. Compared to this reference group, Black survivors (n = 480) who received DVRR experienced 4.66 additional times the odds of reaching advocacy services (95% CI: 3.09–7.04) and male survivors (n = 84) experienced 8.96 additional times the odds (95% CI: 2.81–28.56). Overall, we predict 43% (95% CI: 38–53%) of Latinx survivors (n = 177), 36% (95% CI: 31–40%) of Black survivors (n = 480) and 23% (95% CI: 14–32%) of white survivors (n = 83); 37% (95% CI: 33–40%) of women (n = 656) and 29% (95% CI: 18–42%) of men (n = 84) received advocacy services with DVRR.ConclusionDirect-to-advocacy ED referrals facilitated by eHealth technology improve access to advocacy care for all survivors in this sample; marginalized racial and ethnic groups most often victimized by DV appear to have the highest rates of connection to advocacy.