bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vivo and in vitro matured bovine oocytes present a distinct pattern of single-cell gene expression
Authors: Caetano Lisandra C. , Verruma Carolina G. , Pinaffi Fabio L.V. , Jardim Izabelle B. , Furtado Gilvan P. , Silva Luciano A. , Furtado Cristiana L.M. , Rosa-e-Silva Ana Carolina J. de Sá 
Published: October 2022

SummaryOocyte gene expression is a well controlled event that promotes gamete competence to undergo maturation, fertilization, and to support early embryo development, directly affecting reproductive outcomes. Considering that in vivo controlled ovarian stimulation or in vitro maturation (IVM) for the acquisition of mature oocytes has distinct implications for gene expression, we sought to evaluate the effects of these procedures on the expression of competence-related genes in single-cell oocytes. Healthy Nelore cows of reproductive age were synchronized to harvest in vivo matured oocytes; ovaries from slaughtered animals were used to obtain cumulus–oocyte complexes that were in vitro matured. Single-cell gene expression was performed using TaqMan Low-Density Arrays and 42 genes were evaluated. In silico analysis of protein interactions and Gene Ontology (GO) analysis was performed. Reduced gene expression was observed for 24 targets in IVM oocytes when compared with those of in vivo matured oocytes (P < 0.05). Differences ranged from 1.5-fold to 4.8-fold higher in in vivo oocytes and the BMP15 (5.28), GDF9 (6.23), NOBOX (7.25), HSPA8 (7.85) and MSX1 (11.00) showed the greatest fold increases. The strongest score of functional interactions was observed between the CDC20 and CKS2, with the differentially expressed gene CDC20 being the main marker behind GO enrichment. IVM negatively affected the expression of important genes related to oocyte competency, and showed higher expression levels in in vivo matured oocytes. In vivo controlled ovarian stimulation may be a better strategy to achieve proper oocyte competence and increase the success of assisted reproductive technologies.
Dementia caregiver burdens predict overnight hospitalization and hospice utilization
Authors: Sullivan Suzanne S. , de Rosa Cristina , Li Chin-Shang , Chang Yu-Ping 
Published: October 2022

AbstractObjectivesTo determine sociodemographics and caregiver burdens associated with overnight hospitalization, hospice utilization, and hospitalization frequency among persons with dementia (PWD).MethodsCross-sectional analysis of PWD (n = 899) of the National Health and Aging Trends Study linked to the National Study of Caregiving. Logistic and proportional odds regression determined the effects of caregiver burdens on overnight hospitalization, hospice use, and hospitalization frequency. Differences between PWD alive not-alive groups were compared on overnight hospitalization and frequency.ResultsAlive PWD (n = 804) were 2.36 times more likely to have an overnight hospital stay (p = 0.004) and 1.96 times more likely to have multiple hospitalizations when caregivers found it physically difficult to provide care (p = 0.011). Decedents aged 65–74 (n = 95) were 4.55 times more likely to experience overnight hospitalizations than 85+, hospitalizations were more frequent (odds ratio [OR] = 4.84), and there was a significant difference between PWD alive/not alive groups (p = 0.035). Decedents were 5.60 times more likely to experience an overnight hospitalization when their caregivers had financial difficulty, hospitalizations were more frequent when caregivers had too much to handle (OR = 8.44) and/or no time for themselves (OR = 10.67). When caregivers had no time for themselves, a significant difference between alive/not alive groups (p = 0.018) was detected in hospitalization frequency. PWD whose caregivers had emotional difficulty helping were 5.89 times more likely to utilize hospice than caregivers who did not report emotional difficulty.Significance of resultsCare transitions among PWD at the end of life are impacted by the circumstances and experiences of their caregivers. Subjective caregiver burdens represent potentially modifiable risks for undesired care transitions and opportunities for promoting hospice use. Future work is warranted to identify and address these issues as they occur.
Assessing the authority of the ICRC Customary IHL Study
Authors: Milanovic Marko , Sivakumaran Sandesh 
Published: October 2022

AbstractThis article examines the authority of the 2005 International Committee of the Red Cross Study on Customary international humanitarian law within the international legal system by collecting and analysing citations to the Study in documents containing expressions of State positions, in the judgments of international and domestic courts and tribunals and in the outputs of other influential actors. Our analysis establishes that the Study is increasingly seen as a highly authoritative instrument, such that a particular proposition will be found to reflect customary international law simply on the basis that the Study says so. We argue that the Study's authority will likely only increase over time.
To what extent do social support and mastery mediate the association between childhood maltreatment and depression? A sequential causal mediation analysis
Authors: Su Y. Y. , Li M. , D'Arcy C. , Caron J. , O'Donnell K. , Meng X. 
Published: October 2022

Abstract

Aims
This study aimed to examine the independent roles of various childhood maltreatment (CM) subtypes in the development of depression; quantify the joint mediation effect of social support and mastery in the association between subtypes of CM and depression and examine the additional contribution of mastery beyond the effect that is operating through social support to this relationship.

Methods
Data analysed were from the Zone d’Épidémiologie Psychiatrique du Sud-Ouest de Montréal, an ongoing longitudinal population-based study. In total, 1351 participants with complete information on the studied variables were included. The propensity score matching and inverse-probability weighted regression adjustment estimation methods were used to minimise the potential confounding in the relationship between CM and major depression. We then used inverse odds ratio-weighted estimation to estimate the direct effects of maltreatment and indirect effects of social support and mastery.

Results
We found that exposures to all maltreatment subtypes increased the risk of subsequent depression. The joint mediating effect of social support and mastery explained 37.63–46.97% of the association between different maltreatment subtypes and depression. The contribution of these two mediators differed by maltreatment subtypes, with social support being the major contributor to the mediating effect.

Conclusions
The findings of the study not only provide scientific evidence on the importance of psychosocial attributes in the development of major depression but also suggest that prevention and invention strategies should focus on these psychosocial attributes to effectively break the vicious cycle of CM on major depression.
Inverse hydride shuttle catalysis enables the stereoselective one-step synthesis of complex frameworks
Authors: Klose Immo , Di Mauro Giovanni , Kaldre Dainis , Maulide Nuno 
Published: October 2022

AbstractThe rapid assembly of complex scaffolds in a single step from simple precursors identifies as an ideal reaction in terms of efficiency and sustainability. Indeed, the direct single-step synthesis of complex alkaloid frameworks remains an unresolved problem at the heart of organic chemistry in spite of the tremendous progress of the discipline. Herein, we present a broad strategy in which dynamically assembled ternary complexes are converted into valuable azabicyclic scaffolds based on the concept of inverse hydride shuttle catalysis. The ternary complexes are readily constructed in situ from three simple precursors and enable a highly modular installation of various substitution patterns. Upon subjection to a unique dual-catalytic system, the transient intermediates undergo an unusual hydride shuttle process that is initiated by a hydride donation event. Furthermore, we show that, in combination with asymmetric organocatalysis, the product alkaloid frameworks are obtained in excellent optical purity.
Study of bearing strength for injection molded GFRPP composites under dry and wet conditions
Authors: Megahed A. A. , Osama M. M. , Selmy A. I. , Abdelhaleem Ayman M. M. 
Published: October 2022

AbstractThermoplastics and fiber-reinforced thermoplastics represent great deals in nowadays industries and applications where some of these applications are projected to wet environment. The present study investigates the effect of water moisture on the bearing strength (BS) of Polypropylene (PP) and glass fiber (GF) reinforced Polypropylene (GFRPP) composites. PP and GFRPP are produced by injection molding using different GF weight fractions (wt%), 10, 20, and 30 wt%, and two different initial fiber lengths 12 and 24 mm. A burnout test indicated that produced specimens with 12 mm long fibers have higher final fiber lengths than those made of 24 mm long fibers. More water was absorbed for higher GF weight fractions. The results of the dry bearing test showed higher bearing strengths for specimens with higher GF wt% and longer fibers. The same observation was obtained from wet tests, while, wet-tested specimens of all compositions have higher strengths than their dry counterparts. Strain-at-break seemed to be significantly reduced by water absorption for all specimens. Specimens tested in wet conditions have different fracture morphology than dry ones due to the change in the mechanical behavior of the materials after water immersion.
Cost analysis of pre-pectoral implant-based breast reconstruction
Authors: Chinta Sachin , Koh Daniel J. , Sobti Nikhil , Packowski Kathryn , Rosado Nikki , Austen William , Jimenez Rachel B. , Specht Michelle , Liao Eric C. 
Published: October 2022

AbstractWith improvement in mastectomy skin flap viability and increasing recognition of animation deformity following sub-pectoral implant placement, there has been a transition toward pre-pectoral breast reconstruction. While studies have explored the cost effectiveness of implant-based breast reconstruction, few investigations have evaluated cost with respect to pre-pectoral versus sub-pectoral breast reconstruction. A retrospective review of 548 patients who underwent mastectomy and implant-based breast reconstruction was performed from 2017 to 2020. The demographic and surgical characteristics of the pre-pectoral and sub-pectoral cohorts were well matched, except for reconstructive staging, as patients who underwent pre-pectoral reconstruction were more likely to undergo single-stage instead of two-stage reconstruction. Comparison of institutional cost ratios by reconstructive technique revealed that the sub-pectoral approach was more costly (1.70 ± 0.44 vs 1.58 ± 0.31, p < 0.01). However, further stratification by laterality and reconstructive staging failed to demonstrate difference in cost by reconstructive technique. These results were confirmed by multivariable linear regression, which did not reveal reconstructive technique to be an independent variable for cost. This study suggests that pre-pectoral breast reconstruction is a cost-effective alternative to sub-pectoral breast reconstruction and may confer cost benefit, as it is more strongly associated with direct-to-implant breast reconstruction.
Pressure driven magnetic order in Sr$$_{1-x}$$Ca$$_x$$Co$$_2$$P$$_2$$
Authors: Forslund Ola Kenji , Andreica Daniel , Sassa Yasmine , Imai Masaki , Michioka Chishiro , Yoshimura Kazuyoshi , Guguchia Zurab , Shermadini Zurab , Khasanov Rustem , Sugiyama Jun , Månsson Martin 
Published: October 2022

AbstractThe magnetic phase diagram of Sr$$_{1-x}$$

1
-
x

Ca$$_x$$

x

Co$$_2$$

2

P$$_2$$

2

as a function of hydrostatic pressure and temperature is investigated by means of high pressure muon spin rotation, relaxation and resonance ($$\mu ^+$$

μ
+

SR). The weak pressure dependence for the $$x\ne 1$$

x
≠
1

compounds suggests that the rich phase diagram of Sr$$_{1-x}$$

1
-
x

Ca$$_x$$

x

Co$$_2$$

2

P$$_2$$

2

as a function of x at ambient pressure may not solely be attributed to chemical pressure effects. The $$x=1$$

x
=
1

compound on the other hand reveals a high pressure dependence, where the long range magnetic order is fully suppressed at $$p_{\rm{c2}}\approx 9.8$$

p

c
2

≈
9.8

kbar, which seem to be a first order transition. In addition, an intermediate phase consisting of magnetic domains is formed above $$p_{\rm{c1}}\approx 8$$

p

c
1

≈
8

kbar where they co-exist with a magnetically disordered state. These domains are likely to be ferromagnetic islands (FMI) and consist of an high- (FMI-$$\textcircled {1}$$

1

) and low-temperature (FMI-$$\textcircled {2}$$

2

) region, respectively, separated by a phase boundary at $$T_{\rm{i}}\approx 20$$

T
i

≈
20

K. This kind of co-existence is unusual and is originating from a coupling between lattice and magnetic degrees of freedoms.
Evaluation of Circle of Willis variants using magnetic resonance angiography
Authors: Kızılgöz Volkan , Kantarcı Mecit , Kahraman Şevket 
Published: October 2022

AbstractThe Circle of Willis (COW) is an important collateral pathway to protect the persistence of cerebral blood perfusion. This study aims to investigate the morphological variants of this significant vascular structure with a large study population. 867 patients who had undergone MR angiography (MRA) evaluation were enrolled in this study. The MRA images of these patients obtained by the three-dimensional time-of-flight technique were re-interpreted to measure the vessel diameters of all components of the COW and classify the COW variations. In addition, correlations of the vessel calibers and the integrity of the COW with gender and age groups were presented. There was female dominance in the study population, and the mean age was 48. Type A was the most common variation in anterior (75.78%) and posterior (53.98%) circulation. Types G and H were the other common variation in the anterior circulation, and types E and D were the second and third common variations in the posterior COW, respectively. Smaller calibration for both ICAs, both P1s and BA were observed in females compared with the male group. Diameters of the BA, and both P1 segments were lower, and the left PCom diameter was significantly higher in the patients with a complete circle. There was a significant sex and age difference regarding the distribution of the complete, partially complete, and incomplete circle groups. The significant differences in the vessel calibers of specific components of the COW for complete, partial, and incomplete circulations revealed by this study should be explained with further research. In addition, meta-analyses with other studies in the literature might be a guide to understanding the morphological alterations of the COW and their relationships with a complete and non-complete circle.
A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine
Authors: Corrêa Hugo de Luca , Raab Artur Temizio Oppelt , Araújo Thamires Marra , Deus Lysleine Alves , Reis Andrea Lucena , Honorato Fernando Sousa , Rodrigues-Silva Paolo Lucas , Neves Rodrigo Vanerson Passos , Brunetta Henver Simionato , Mori Marcelo Alves da Silva , Franco Octávio Luiz , Rosa Thiago dos Santos 
Published: October 2022

AbstractKlotho is an anti-aging protein with several therapeutic roles in the pathophysiology of different organs, such as the skeletal muscle and kidneys. Available evidence suggests that exercise increases Klotho levels, regardless of the condition or intervention, shedding some light on this anti-aging protein as an emergent and promising exerkine. Development of a systematic review and meta-analysis in order to verify the role of different exercise training protocols on the levels of circulating soluble Klotho (S-Klotho) protein. A systematic search of the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE through PubMed, EMBASE, CINAHL, CT.gov, and PEDro. Randomized and quasi-randomized controlled trials that investigated effects of exercise training on S-Klotho levels. We included 12 reports in the analysis, comprising 621 participants with age ranging from 30 to 65 years old. Klotho concentration increased significantly after chronic exercise training (minimum of 12 weeks) (Hedge’ g [95%CI] 1.3 [0.69–1.90]; P < 0.0001). Moreover, exercise training increases S-Klotho values regardless of the health condition of the individual or the exercise intervention, with the exception of combined aerobic + resistance training. Furthermore, protocol duration and volume seem to influence S-Klotho concentration, since the effect of the meta-analysis changes when subgrouping these variables. Altogether, circulating S-Klotho protein is altered after chronic exercise training and it might be considered an exerkine. However, this effect may be influenced by different training configurations, including protocol duration, volume, and intensity.
Behaviour Real-Time Spatial Tracking Identification (BeRSTID) used for Cat Behaviour Monitoring in an Animal Shelter
Authors: Eagan B. H. , Eagan B. , Protopopova A. 
Published: October 2022

AbstractEfficiently tracking animal behaviour in an animal shelter has direct lifesaving applications. Individualized care and early recognition of distress in cats are often missed. However, monitoring behaviour is a challenge as time and financial resources are often limited, and the size and needs of animal populations within shelters are commonly in flux. Our research required a method of behavioural observation that was simple, accessible, used limited human and computer resources and allowed for real-time feedback. Here, we present BeRSTID, an open-source behaviour real-time spatial tracking identification system demonstrated on six cats in an animal shelter using unique 2D fiducial markers. The markers were attached to custom veterinary paper identification collars for feedback on individual animal behaviour over time. Our findings show that BeRSTID correlated closely to human-coded data in both real-time and post-event processing modes of eating and drinking behaviours of cats in naturalistic shelter environments. By building upon a lateral concept of marker tracking for direct applied use in a new context, we present a low-barrier user-friendly solution using common technologies that can track animals for research and, with further development, may help improve welfare in animal care facilities such as shelters. Extensions of BeRSTID may be generalized to track unique subjects in varied environments for multiple use cases.
Death at watersheds: Galaxy quenching in low-density environments
Authors: Einasto Maret , Kipper Rain , Tenjes Peeter , Einasto Jaan , Tempel Elmo , Liivamägi Lauri Juhan 
Published: October 2022

Context.The evolution of galaxies is influenced by their local and global environment in the cosmic web. Galaxies with very old stellar populations (VO galaxies withDn(4000) index ≥1.75) mostly lie in the centres of galaxy clusters, where they evolve under the influence of processes characteristic of high-density cluster environments. However, VO galaxies have also been found in poor groups in global low-density environments between superclusters, which we call watershed regions.Aims.Our aim is to analyse the properties of galaxies in various cosmic environments with a focus on VO galaxies in the watershed regions to understand their evolution, and the origin of the large-scale morphology–density relation.Methods.We employ the Sloan Digital Sky Survey DR10 MAIN spectroscopic galaxy sample in the redshift range 0.009 ≤ z ≤ 0.200 to calculate the luminosity–density field of galaxies, to determine groups and filaments in the galaxy distribution, and to obtain data on galaxy properties. The luminosity–density field with smoothing length 8h−1Mpc,D8, characterises the global environment of galaxies. We analyse the group and galaxy contents of regions with variousD8 thresholds. We divide groups into low- and high-luminosity groups based on the highest luminosity of groups in the watershed region,Lgr ≤ 15 × 1012h−2L⊙. We compare the stellar masses, the concentration index, and the stellar velocity dispersions of quenched and star-forming galaxies among single galaxies, satellite galaxies, and the brightest group galaxies (BGGs) in various environments.Results.We show that the global density is most strongly related to the richness of galaxy groups. Its influence on the overall star formation quenching in galaxies is less strong. Correlations between the morphological properties of galaxies and the global density field are the weakest. The watershed regions withD8 < 1 are populated mostly by single galaxies, constituting 70% of all galaxies there, and by low-luminosity groups. Still, approximately one-third of all galaxies in the watershed regions are VO galaxies. They have lower stellar masses, smaller stellar velocity dispersions, and stellar populations that are up to 2 Gyr younger than those of VO galaxies in other global environments. In higher density global environments (D8 > 1), the morphological properties of galaxies are very similar. Differences in galaxy properties are the largest between satellites and BGGs in groups.Conclusions.Our results suggest that galaxy evolution is determined by the birthplace of galaxies in the cosmic web, and mainly by internal processes which lead to the present-day properties of galaxies. This may explain the similarity of (VO) galaxies in extremely different environments.
Erfassung der kommunikativen Lebensqualität und Partizipation bei Demenz: Scoping Review
Authors: Grüning Antje , Oslmeier Charlotte , Türck Julia , Büttner-Kunert Julia 
Published: October 2022

ZusammenfassungDie steigende Zahl der Menschen, die an Demenz erkranken, stellt Fachkräfte und Angehörige vor große Herausforderungen. Die Erfassung der kommunikationsbezogenen Lebensqualität und Partizipation sollte fester Bestandteil der Versorgung von Menschen mit Demenz sein. Um einen Überblick über die verfügbaren Verfahren hierfür zu erhalten, wurde von März bis Mai 2020 eine Datenbankrecherche in PSYNDEX, ScienceDirect und Web of Science Core Collection nach PRISMA Kriterien durchgeführt. Insgesamt wurden 22 Verfahren in die Analyse begründet eingeschlossen. Von diesen erfassen nur sieben die Kommunikationsfähigkeit und die soziale Interaktion, neun liegen insgesamt in deutscher Sprache vor. Siebzehn der 22 Verfahren stellen reine Fremdbeurteilungsverfahren dar. Bei der Erfassung der Lebensqualität spielt die Kommunikationsfähigkeit eine untergeordnete Rolle, die Beurteilung erfolgt häufig einseitig. Von praktischem Nutzen sind: DCI, CODEM, ISEKAD und Z-CADA.