bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal MRI brain studies in live adult zebrafish
Authors: Hamilton Noémie , Allen Claire , Reynolds Steven 
Published: December 2022

AbstractZebrafish (Danio rerio) has been successfully used for decades in developmental studies and disease modelling. The remarkable uptake of zebrafish as a model system is partly due to its transparency during the early weeks of its development, allowing in vivo imaging of cellular and molecular processes. However, this key advantage wears off when tissues become opaque as the animal reaches juvenile and adult stages, rendering access to tissues for live imaging and longitudinal studies difficult. Here we provide a novel approach to image and assess tissue integrity of adult zebrafish using MRI on live zebrafish suitable for longitudinal studies. We built a 3D‐printed life support chamber and designed a protocol‐directed sedation regime to recover adult zebrafish after scanning in a 9.4 T MRI scanner. Our life support chamber is cheap and easy to create using 3D printing, allowing other groups to copy our template for quick setup. Additionally, we optimized the delivery of contrast agent to enhance brain signals in order to refine current delivery, usually delivered intravenously in rodents. We show here that immersion in gadolinium was a viable alternative to intraperitoneal injection to reduceT1relaxation times. This resulted in protocol refinement as per the 3Rs guidelines and improved image contrast in adult zebrafish disease models. In conclusion, we provide here a detailed methodology to allow longitudinal studies of brain tissue integrity of adult zebrafish, combining safe and efficient delivery of contrast agent and live MRI. This technique can be used to bridge the gap between in vivo studies and longitudinal brain analysis in adult zebrafish, and can be applied to the ever‐growing number of adult zebrafish models of ageing and neurodegenerative diseases.
Restrictions on Data Transfers and Trade Agreements
Authors: Naef Tobias 
Published: December 2022

AbstractIn reaction to the stalemate in the multilateral trading system, international governance of digital trade has gradually shifted toward bilateral and regional trade agreements. This allowed countries to start to regulating cross-border flows of personal data outside the WTO framework. The first section of this chapter traces the development of data flow clauses in the trade agreements of the EU, the US, and other countries. It also looks at the negotiations of the big trade agreements in the late 2010s, such as the TTIP, the TiSA, and the TPP (Sect. 5.1). The second section outlines the scope for data flow clauses in the trade agreements of the EU based on different legal requirements stemming from the architecture of EU law, the GDPR, and other regulations. These requirements include the primacy of fundamental rights over international law with regard to the right to continuous protection of personal data in Article 8 CFR, the accommodation of the legal mechanisms for the transfer of personal data in the GDPR, the inclusion of cooperation mechanisms on the basis of Article 50 GDPR, and the ban of data localization requirements beyond data protection and privacy concerns. These legal requirements are necessary to consider when drafting data flow clauses for EU trade agreements (Sect. 5.2). The third section of this chapter offers and analyzes four potential designs for data flow clauses for EU trade agreements (Sect. 5.3). The fourth section is dedicated to the analysis of the EU model data flow clauses that the European Commission introduced as a template for future trade negotiations in 2018 (Sect. 5.4).
Orte und Räume in Romanen
Authors: Schumacher Mareike K. 
Published: December 2022

ZusammenfassungDieses Kapitel zeigt Analysen, die mit Hilfe des Raum-Classifiers Einstiegspunkte in digital-literaturwissenschaftliche Erkenntnisprozesse bieten. Die Studien sind in drei Perspektiven unterteilt: eine, die das gesamte Korpus, eine die die vier jahrhundertspezifischen Teilkorpora und eine, die ein Einzeltextphänomen in den Blick nimmt. Bei jedem Ansatz wird die Frage berücksichtigt, inwiefern dieser an nicht-digitale Literaturwissenschaften anschließt oder deren Erkenntnisse weiterdenkt.
Data assimilation as a key step towards the implementation of an efficient management of dissolved oxygen in land-based aquaculture
Authors: Royer Edouard , Pastres Roberto 
Published: December 2022

AbstractA data assimilation (DA) methodology, e.g. the continuous-discrete Kalman filter (CD-KF), was applied to the assimilation of dissolved oxygen data, in order to obtain a dynamic estimation of the oxygen demand in a land-based aquafarm. The CD-KF was implemented on a dynamic model, which included as state variables the concentration of dissolved oxygen (DO) and fish respiration rate: the latter was considered as a non-observable stochastic variable. The model was applied to a 1-month long set of observations collected at a raceway rainbow trout farm, including (1) hourly time series of water temperature and dissolved oxygen concentration in the raceway influent and effluent and (2) a daily time series of fish number and fish weight distribution. The results show that the assimilation of DO data led to a dynamic estimate of DO demand which showed changes in the daily mean and the daily pattern: these were related to changes in the feeding regime. Furthermore, the methodology provided accurate short-term predictions of the DO concentration also in the presence of short-term fluctuations, which would be very difficult to relate to external forcings in a mechanistic model. These findings indicate that DA could be effectively used to design and implement efficient and robust control systems for optimizing the oxygen supply, thus contributing to the implementation of Precision Fish Farming in land-based aquafarms.
Becoming a Guest: On Proximity and Distance in Mental Health Home Treatment
Authors: Hochwarter Stefan , Schwarz Julian , Muehlensiepen Felix , Monteiro Eric 
Published: December 2022

AbstractMental health home treatment is a service where patients with severe mental illnesses are visited by a multiprofessional psychiatric care team at their homes. In Germany, inpatient-equivalent home treatment as a specialized form of home treatment has been offered by hospitals since 2018. In its early stage, the shift of care activities out of the hospital toward the patient’s home opened up a new set of problems and blurred the existing boundaries. This ethnographic study follows two home treatment teams and provides an in-depth description of their work. The findings are presented by three themes from our data analysis: (i) closeness and familiarity; (ii) bridging the distance; and (iii) tensions of proximity and distance. We then discuss the findings with the guiding lens ofBecoming a Guest, which refers to the ambiguity of proximity and distance. The contribution for computer-supported cooperative work (CSCW) is twofold; on the one hand, we provide a detailed account of mental health home treatment, and on the other hand, we outline a conceptual model that helps to describe and analyze similar cases. We conclude the paper with directions for further research.
Energy in Newtonian Gravity
Authors: Bengtsson Ingemar , Eklund Tobias 
Published: December 2022

AbstractIn Newtonian gravity it is a moot question whether energy should be localized in the field or inside matter. An argument from relativity suggests a compromise in which the contribution from the field in vacuum is positive definite. We show that the same compromise is implied by Noether’s theorem applied to a variational principle for perfect fluids, if we assume Dirichlet boundary conditions on the potential. We then analyse a thought experiment due to Bondi and McCrea that gives a clean example of inductive energy transfer by gravity. Some history of the problem is included.
The Gap in Mental Health Service Utilization Among United Methodist Clergy with Anxiety and Depressive Symptoms
Authors: Biru Blen , Yao Jia , Plunket James , Hybels Celia F. , Kim Eunsoo Timothy , Eagle David E. , Choi Jessica Y. , Proeschold-Bell Rae Jean 
Published: December 2022

AbstractClergy are tasked with multiple interpersonal administrative, organizational, and religious responsibilities, such as preaching, teaching, counseling, administering sacraments, developing lay leader skills, and providing leadership and vision for the congregation and community. The high expectations and demands placed on them put them at an increased risk for mental distress such as depression and anxiety. Little is known about whether and how clergy, helpers themselves, receive care when they experience mental distress. All active United Methodist Church (UMC) clergy in North Carolina were recruited to take a survey in 2019 comprising validated depression and anxiety screeners and questions about mental health service utilization. Bivariate and Poisson regression analyses were conducted on the subset of participants with elevated depressive and anxiety symptoms to determine the extent of mental health service use during four different timeframes and the relationship between service use and sociodemographic variables. A total of 1,489 clergy participated. Of the 222 (15%) who had elevated anxiety or depressive symptoms or both, 49.1% had not ever or recently (in the past two years) seen a mental health professional. Participants were more likely to report using services currently or recently (in the past two years) if they were younger, had depression before age 21, or "very often" felt loved and cared for by their congregation. The rate of mental health service use among UMC clergy is comparable to the national average of service use by US adults with mental distress. However, it is concerning that 49% of clergy with elevated symptoms were not engaged in care. This study points to clergy subgroups to target for an increase in mental health service use. Strategies to support clergy and minimize mental health stigma are needed.
The dynamics of adolescents’ pubertal maturation, depressive symptoms and friendship networks: stochastic actor-oriented model
Authors: Yu Yi-Fang , Ting Te-Tien , Liao Jay Chiehen , Tsai Meng-Che , Lin Chung-Ying , Hsieh Yi-Ping , Strong Carol 
Published: December 2022

Abstract
This study aimed to examine whether adolescents select friends based on their friends’ levels of depressive symptoms, and to determine whether the potential homophily phenomenon for depressive symptoms is attenuated after considering pubertal maturation and gender. Data were from the first three waves of the Taiwan Youth Project, a longitudinal study that annually surveys 7th graders from 40 junior high schools. Participants were asked at each wave to fill out a survey including depressive symptoms, pubertal maturation, and to name three best friends in school. Stochastic actor-oriented models were built to explore the dynamic changes in friendship networks by estimating the probability of the friendship connections and behavioral changes depending on the individual’s current network position and behavioral status. We used a sample of 2,336 adolescents. From 8 to 9th grade, adolescents tended to select friends who were similar in terms of their levels of depressive symptoms (B = 0.358, SE = 0.131, p < .001), without adjusting for gender and pubertal maturation. This homophily effect based on depressive symptoms became non-significant when pubertal maturation was included. Adolescents’ depressive symptoms did not further influence their friends’ depression levels, after controlling for pubertal maturation and gender. Future studies should further examine the mechanisms and group dynamics within clusters of adolescents who are depressed. Providing a supportive environment and tools is warranted to help adolescents cope with negative emotions within their peer group.
Low incidence of advanced neurological burden but high incidence of age-related conditions that are dementia risk factors in aging people living with HIV: a data-linkage 10-year follow-up study
Authors: Aung Htein Linn , Bloch Mark , Vincent Trina , Mao Limin , Brew Bruce J. , Cysique Lucette A. 
Published: December 2022

Abstract
Although increasing research is focusing on age-related comorbidities (ARC) among people living with HIV (PLHIV), no studies have concomitantly assessed non-HIV age-related neurological disorders (e.g., Alzheimer’s dementia). A total of 254 PLHIV and 69 HIV-negative controls completed baseline medical history and cognitive testing. ARC data were collected from medical records over the subsequent 9-10 years and included all types of strokes, all types of dementia, mild cognitive impairment, Parkinson's disease, motor neuron disease (grouped into a non-HIV age-related neurological category), cardiovascular disease, chronic kidney disease, chronic liver disease, chronic lung disease, non-AIDS cancers, osteoporosis, and diabetes. Kaplan–Meier curves assessed differences in the incident rates (per 1000 person year) of groups of ARC as defined above and combined ARC (i.e., development of any of the ARC) among younger (baseline age < 50) and older (baseline age ≥ 50) PLHIV and younger and older controls. Cox-proportional hazard models assessed the individual and interaction effects of HIV status and chronological age, in addition to a range of demographic and clinical variables including historical and baseline HIV brain involvement on the risk of developing combined ARC. Older PLHIV had a higher incidence of cardiovascular disease, osteoporosis, and combined ARC compared to other groups (p < 0.05). Incident rate of non-HIV age-related neurological disorders was 2.3 [0.93, 4.79] per 1000 person year. While this incident rate was higher in older PLHIV (5.37 [1.97, 11.92]) than older HIV-negative participants (3.58 [0.18-17.67]), this was not significant. In multivariate analyses, HIV status and chronological age, but not their interaction, and smoking were associated with higher risk of combined ARC (p < 0.05). In analyses focusing on PLHIV, older age and taking abacavir/efavirenz/atazanavir/darunavir containing antiretroviral treatments at the time of diagnosis were associated with greater ARC (p < 0.05). Non-HIV age-related neurological disorders are uncommon in older PLHIV, where the majority were < 70 years of age at the end of follow-up. However, the greater burden of ARC among older PLHIV, most of which are established dementia risk factors, warrants the establishment of commensurate prevention strategies and greater attention to neurocognitive screening.
Delineating a volcanic aquifer using groundwater-induced gravity changes in the Tatun Volcano Group, Taiwan
Authors: Lien Tzuyi , Chang Emmy T. , Hwang Cheinway , Cheng Ching-Chung , Chen Rou-Fei , Mu Chung-Hsiang 
Published: December 2022

AbstractThe Tatun Volcanic Group (TVG) is an active volcanic system that poses potential volcanic hazards to northern Taiwan. Groundwater migration can be sensitive to volcanic activities and can induce temporal gravity changes. Here we conducted four gravity measurement campaigns in 2012 with two CG5 relative gravimeters at a total of 31 gravity monitoring sites to probe the spatiotemporal groundwater variability in the TVG area. With careful adjustments to the gravity measurements, the standard point gravity error was approximately 8 μGal on average. The observed gravity changes were compared with the groundwater-induced gravity variations derived from two hydrological models: the continuous flow model that consisted of one permeable layer (Model A) and a dynamic groundwater flow model that used the hydrological solver MODFLOW (Model B). The results show that only gravity observations in the central TVG match the simulated gravity pattern, i.e., the hydrology in the central TVG follows free groundwater flows within the interconnected and porous strata. On the other hand, inconsistencies between simulated and observed gravity changes range from + 40 to – 80 μGal. The discrepancies were located at the eastern and western areas in the TVG and showed opposite variations over time. This pattern of temporal variability cannot be attributed to the use of shallow aquifer models that merely reflect the surface recharges and discharges. We infer that the pattern stems from deep flows, such as hydrothermal fluids alternately replenishing aquifers to the east and west of the TVG, i.e., deep fluid conduits may have developed to the east and west of the TVG and bypassed the central area.
Introducing a web-based portal to explore the concept of coastal resilience
Authors: Townend Ian , Hill Chris , Sadler Jason , Waldock Ian 
Published: December 2022

AbstractFor operational use there is a need to identify a set of measures that quantify the resilience. The ‘CoastRes’ project, a component of the UK Climate Resilience Programme, examined how an operational interpretation of resilience might be applied to the coast, building on existing approaches to shoreline management in the UK. The development of the methodology and resulting Coastal Resilience Model has been reported elsewhere. For this communication, we provide a brief summary of the management framework, the Coastal Resilience Model (CRM) and the preparation of the datasets, so that the limitations of the data available at a national scale are clear. We then illustrate how the Coastal Resilience Model has been implemented as the web-based CRM Portal. The purpose of the portal is to allow users to explore (i) the implications of future change on local and national resilience; and (ii) their own view of the relative importance of the Performance Measures that make up the Coastal Resilience Index. By exploring the influence of these weightings it is hoped that Stakeholders can develop a shared understanding of what is important for coastal communities. The CRM Portal can be accessed at: https://coastalresilience.uk/crm/.
Analysis of Resilience, Coping Style, Anxiety, and Depression Among Rescue Nurses on EMTs During the Disaster Preparedness Stage in Sichuan, China: A Descriptive Cross-Sectional Survey
Authors: Huang Wenjiao , Li Linqian , Zhuo Yu , Zhang Jianna 
Published: December 2022

Abstract

Objective:
The purpose of this study was to investigate the current situation and influencing factors of resilience, coping style, anxiety, and depression among rescue nurses on Emergency Medical Teams (EMTs) during the disaster preparedness stage, and to explore the relationship between resilience, coping style, anxiety, and depression.

Methods:
A descriptive cross-sectional survey was used. The convenience sampling method was used to select rescue nurses from 4 national EMTs in Sichuan Province, China. CD-RISC, SCSQ, Zung SAS, and SDS were used as research tools.

Results:
A total of 197 valid questionnaires were returned, with a 98.5% response rate. The results of multiple regression analysis showed that average monthly income, depression level, and coping style were the main factors affecting nurses’ resilience. Resilience was significantly and positively correlated with coping style and negatively correlated with anxiety and depression. There were significant differences in SCSQ, Zung SAS, and SDS scores among Clusters.

Conclusion:
In the disaster preparedness stage, rescue nurses on EMTs have a medium level of resilience and good coping styles, but their levels of anxiety and depression are high. It is suggested that more attention should be devoted to the target population to formulate effective intervention plans, reduce psychological pressures, and improve their capacity for coping with disasters.
The gut microbiota is an emerging target for improving brain health during ageing
Authors: Boehme Marcus , Guzzetta Katherine Elizabeth , Wasén Caroline , Cox Laura Michelle 
Published: December 2022

AbstractThe gut microbiota plays crucial roles in maintaining the health and homeostasis of its host throughout lifespan, including through its ability to impact brain function and regulate behaviour during ageing. Studies have shown that there are disparate rates of biologic ageing despite equivalencies in chronologic age, including in the development of neurodegenerative diseases, which suggests that environmental factors may play an important role in determining health outcomes in ageing. Recent evidence demonstrates that the gut microbiota may be a potential novel target to ameliorate symptoms of brain ageing and promote healthy cognition. This review highlights the current knowledge around the relationships between the gut microbiota and host brain ageing, including potential contributions to age-related neurodegenerative diseases. Furthermore, we assess key areas for which gut microbiota-based strategies may present as opportunities for intervention.
Hedging Commodity Price Risk
Authors: Ghoddusi Hamed , Titman Sheridan , Tompaidis Stathis 
Published: December 2022

AbstractWe present an equilibrium model of hedging for commodity processing firms. We show the optimal hedge ratio depends on the convexity of the firm’s cost function and the elasticity of the supply of the input and the demand for the output. Our calibrated model suggests that hedging tends to be ineffective. When uncertainty comes exclusively from either the supply or from the demand side, updating the hedge dynamically, and using nonlinear contracts improves hedging effectiveness. However, with both supply and demand uncertainty, hedging effectiveness can be low even with option-based and dynamic hedging strategies.
Fluctuating maximal God, the problem of inconsistent evil, and spacetime changes
Authors: Lancaster-Thomas Asha 
Published: December 2022

AbstractThe fluctuating maximal God thesis, developed by Jeffrey et al., offers a conception of God that removes the characteristic of divine immutability, allowing the degrees of God's great-making properties to change over time. This god-concept provides a substantial advantage over the ‘static’ maximal God thesis proposed by Yujin Nagasawa if it can adequately sidestep what I call ‘the problem of inconsistent evil’. This problem questions how a static god can be compatible with the inconsistent dispersion of evil in the world. It is founded on the observation that evil is distributed neither equally nor fairly across time, space, and individuals. I distinguish between temporally inconsistent, spatially inconsistent, and interpersonally inconsistent evil and argue that the fluctuating maximal God thesis can account for all types of inconsistent evil if God fluctuates not only through time but also through space.
Two Views of Vulnerability in the Evolution of Canada’s Medical Assistance in Dying Law
Authors: Lazin Sarah J. , Chandler Jennifer A. 
Published: December 2022

AbstractCanada is six years into a new era of legalized medical assistance in dying (MAiD). The law continues to evolve, following a pattern in which Canadian courts rule that legal restrictions on eligibility for MAiD are unconstitutional and Parliament responds by gradually expanding eligibility for MAiD. The central tension underlying this dialogue between courts and government has focused on two conceptions of how to best promote and protect the interests of people who are vulnerable by virtue of intolerable and irremediable suffering due to an illness, disease, or disability. Do we, as a society, have a duty to protect vulnerable people from seeking certain medical procedures that are contrary to their interests, as those are perceived by others? Or do we have a duty to uphold their rights to autonomy, including the right to make choices within a range that may be constrained by many factors, some of which may be socially unjust? This is a recurrent problem in bioethics and medical law, which we explore through the lens of how Canadian courts and Parliament have grappled with defining eligibility for MAiD.